SNRPD2
entrez
6633
canonical
uniprot
P62316
canonical
ensembl
ENSG00000125743
resolver
ensp
ENSP00000342374
resolver
ensp
ENSP00000375798
resolver
ensp
ENSP00000465216
resolver
ensp
ENSP00000465952
resolver
ensp
ENSP00000468247
resolver
enst
ENST00000590212
resolver
genesymbol
SNRPD2
resolver
genesymbol_syn
SNRPD1
resolver
hgnc
HGNC:11159
resolver
uniprot
A8K797
resolver
uniprot
J3KPM5
resolver
uniprot
K7ERG4
resolver
uniprot
P43330
resolver
uniprot_entry
K7ERG4_HUMAN
resolver
uniprot_entry
SMD2_HUMAN
resolver
uniprot_sec
A8K797
resolver
uniprot_sec
J3KPM5
resolver
uniprot_sec
P43330
resolver
amino_acid_sequence
MSLLNKPKSEMTPEELQKREEEEFNTGPLSVLTQSVKNNTQVLINCRNNKKLLGRVKAFDRHCNMVLENVKEMWTEVPKSGKGKKKSKPVNKDRYISKMFLRGDSVIVVLRNPLIAGK
uniprot
proteins
function
FUNCTION: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:28781166). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:23333303, ECO:0000269|PubMed:25555158, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:32494006}.
uniprot
proteins
mass_dalton
13527
uniprot
proteins
protein_family
SnRNP core protein family
uniprot
proteins
pubmed
10025403
uniprot
proteins
pubmed
10500148
uniprot
proteins
pubmed
11991638
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15146077
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16314521
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18984161
uniprot
proteins
pubmed
19325628
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21516107
uniprot
proteins
pubmed
21816274
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23333303
uniprot
proteins
pubmed
25555158
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26912367
uniprot
proteins
pubmed
28076346
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28502770
uniprot
proteins
pubmed
28781166
uniprot
proteins
pubmed
31799625
uniprot
proteins
pubmed
32494006
uniprot
proteins
pubmed
33509932
uniprot
proteins
pubmed
36797247
uniprot
proteins
pubmed
7527560
uniprot
proteins
sequence_length
118
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. {ECO:0000305}.
uniprot
proteins