Gabrg1
entrez
140674
canonical
uniprot
P23574
canonical
ensembl
ENSRNOG00000002360
resolver
ensembl
ENSRNOG00055005249
resolver
ensembl
ENSRNOG00060016429
resolver
ensembl
ENSRNOG00065020724
resolver
ensp
ENSRNOP00000098270
resolver
ensp
ENSRNOP00055006369
resolver
ensp
ENSRNOP00060022667
resolver
ensp
ENSRNOP00065028248
resolver
enst
ENSRNOT00000120635
resolver
enst
ENSRNOT00055008418
resolver
enst
ENSRNOT00060028149
resolver
enst
ENSRNOT00065035131
resolver
genesymbol
Gabrg1
resolver
uniprot_entry
GBRG1_RAT
resolver
amino_acid_sequence
MGSGKVFLFSPSLLWSQTRGVRLIFLLLTLHLGNCIDKADDEDDEDLTMNKTWVLAPKIHEGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWSDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAFVGLRNSTEISHTISGDYIIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSNNKGKTTRDRKLKSKTSVSPGLHAGSTLIPMNNISMPQGEDDYGYQCLEGKDCATFFCCFEDCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL
uniprot
proteins
function
FUNCTION: Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:2170110). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:2170110). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). {ECO:0000250|UniProtKB:P08219, ECO:0000250|UniProtKB:P18507, ECO:0000269|PubMed:2170110}.
uniprot
proteins
mass_dalton
53551
uniprot
proteins
post_translational_modification
PTM: May be palmitoylated. {ECO:0000250|UniProtKB:P22723}.
uniprot
proteins
protein_family
GABRG1 sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
2170110
uniprot
proteins
sequence_length
465
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein {ECO:0000255}. Cell membrane; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 274..294; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 301..320; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 329..349; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 445..465; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins