Mblac1
entrez
330216
canonical
uniprot
Q8BWY4
canonical
ensembl
ENSMUSG00000049285
resolver
ensp
ENSMUSP00000052869
resolver
enst
ENSMUST00000057773
resolver
genesymbol
Mblac1
resolver
uniprot
Q8CHU7
resolver
uniprot_entry
MBLC1_MOUSE
resolver
uniprot_sec
Q8CHU7
resolver
amino_acid_sequence
MNGPVRTEPLHGEIPLLASSGSYSVVVLLRGYAEPQGAGDAVRADGTVTLVLPRGWASDSSRGLAPSADGGSKTALEEAVRGPILVDTGGPWARGALLEALATQGVAPEDVTLVVGTHGHSDHIGNLGLFPEAALLVSHDFCLPEGLYLPHGLCETQPLILGSGLQVWATPGHGGQRDVSVVVEGTSLGTVVVAGDVFERLGDEDSWQALSEDPVAQQRSRERILSVADVVVPGHGAPFRVVRETVKSSEDLICEGKAVA
uniprot
proteins
ec_number
3.1.27.-
uniprot
proteins
function
FUNCTION: Endoribonuclease that catalyzes the hydrolysis of histone-coding pre-mRNA 3'-end. Involved in histone pre-mRNA processing during the S-phase of the cell cycle, which is required for entering/progressing through S-phase. Cleaves histone pre-mRNA at a major and a minor cleavage site after the 5'-ACCCA-3' and the 5'-ACCCACA-3' sequence, respectively, and located downstream of the stem-loop. May require the presence of the HDE element located at the histone pre-RNA 3'-end to avoid non-specific cleavage. {ECO:0000250|UniProtKB:A4D2B0}.
uniprot
proteins
mass_dalton
26923
uniprot
proteins
protein_family
Glyoxalase II family
uniprot
proteins
protein_family
Metallo-beta-lactamase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
260
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:A4D2B0}. Nucleus {ECO:0000250|UniProtKB:A4D2B0}. Note=Localizes in the nucleus during early S-phase of the cell cycle. {ECO:0000250|UniProtKB:A4D2B0}.
uniprot
proteins