MCL1
entrez
4170
canonical
uniprot
Q07820
canonical
ensembl
ENSG00000143384
resolver
ensp
ENSP00000309973
resolver
ensp
ENSP00000358022
resolver
ensp
ENSP00000477624
resolver
enst
ENST00000620947
resolver
genesymbol
MCL1
resolver
genesymbol_syn
BCL2L3
resolver
hgnc
HGNC:6943
resolver
uniprot
A0A087WT64
resolver
uniprot
B2R6B2
resolver
uniprot
C8YZ26
resolver
uniprot
D3DV03
resolver
uniprot
D3DV04
resolver
uniprot
Q9HD91
resolver
uniprot
Q9NRQ3
resolver
uniprot
Q9NRQ4
resolver
uniprot
Q9UHR7
resolver
uniprot
Q9UHR8
resolver
uniprot
Q9UHR9
resolver
uniprot
Q9UNJ1
resolver
uniprot_entry
A0A087WT64_HUMAN
resolver
uniprot_entry
C8YZ26_HUMAN
resolver
uniprot_entry
MCL1_HUMAN
resolver
uniprot_sec
B2R6B2
resolver
uniprot_sec
D3DV03
resolver
uniprot_sec
D3DV04
resolver
uniprot_sec
Q9HD91
resolver
uniprot_sec
Q9NRQ3
resolver
uniprot_sec
Q9NRQ4
resolver
uniprot_sec
Q9UHR7
resolver
uniprot_sec
Q9UHR8
resolver
uniprot_sec
Q9UHR9
resolver
uniprot_sec
Q9UNJ1
resolver
amino_acid_sequence
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
uniprot
proteins
function
FUNCTION: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. {ECO:0000269|PubMed:10766760, ECO:0000269|PubMed:16543145}.
uniprot
proteins
mass_dalton
37337
uniprot
proteins
mutagenesis
MUTAGEN 5; /note="K->R: Reduced ubiquitination."; /evidence="ECO:0000269|PubMed:15989957"; MUTAGEN 40; /note="K->R: Reduced ubiquitination."; /evidence="ECO:0000269|PubMed:15989957"; MUTAGEN 127; /note="D->A: Abolishes formation of 28 and 17 kDa cleavage products by CASP3. Abolishes cleavage by caspase-3; when associated with A-157."; /evidence="ECO:0000269|PubMed:15122313"; MUTAGEN 136; /note="K->R: Reduced ubiquitination."; /evidence="ECO:0000269|PubMed:15989957"; MUTAGEN 157; /note="D->A: Abolishes formation of 23 and 21 kDa cleavage products by CASP3. Abolishes cleavage by caspase-3; when associated with A-127."; /evidence="ECO:0000269|PubMed:15122313"; MUTAGEN 159; /note="S->A: Loss of phosphorylation by GSK3 and loss of ubiquitination increasing protein stability."; /evidence="ECO:0000269|PubMed:16543145"; MUTAGEN 162; /note="S->A: Abolishes mitochondrial localization and decreases stability."; /evidence="ECO:0000269|PubMed:15241487, ECO:0000269|PubMed:23024798"; MUTAGEN 162; /note="S->A: No effect."; /evidence="ECO:0000269|PubMed:15241487, ECO:0000269|PubMed:23024798"; MUTAGEN 163; /note="T->A,E: No effect on mitochondrial localization."; /evidence="ECO:0000269|PubMed:15241487"; MUTAGEN 163; /note="T->A: Abolishes phosphorylation by MAPK. No effect on phosphorylation induced by okadaic acid or taxol."; /evidence="ECO:0000269|PubMed:15241487"; MUTAGEN 194; /note="K->R: Reduced ubiquitination."; /evidence="ECO:0000269|PubMed:15989957"; MUTAGEN 197; /note="K->R: Reduced ubiquitination."; /evidence="ECO:0000269|PubMed:15989957"; MUTAGEN 208; /note="K->R: No effect on ubiquitination."; /evidence="ECO:0000269|PubMed:15989957"; MUTAGEN 234; /note="K->R: No effect on ubiquitination."; /evidence="ECO:0000269|PubMed:15989957
uniprot
proteins
post_translational_modification
PTM: Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment.; PTM: Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region. {ECO:0000269|PubMed:12223490, ECO:0000269|PubMed:15241487, ECO:0000269|PubMed:23024798}.; PTM: Phosphorylated on Ser-159, by GSK3, in response to IL3/interleukin-3 withdrawal. Phosphorylation at Ser-159 induces ubiquitination and proteasomal degradation, abrogating the anti-apoptotic activity. Treatment with taxol or okadaic acid induces phosphorylation on additional sites. {ECO:0000269|PubMed:16543145}.; PTM: Ubiquitinated. Ubiquitination is induced by phosphorylation at Ser-159 (PubMed:16543145). Deubiquitinated by USP20; leading to increased stability (PubMed:35063767). {ECO:0000269|PubMed:16543145, ECO:0000269|PubMed:35063767}.
uniprot
proteins
protein_family
Bcl-2 family
uniprot
proteins
pubmed
10634649
uniprot
proteins
pubmed
10766760
uniprot
proteins
pubmed
10837489
uniprot
proteins
pubmed
11130466
uniprot
proteins
pubmed
12149273
uniprot
proteins
pubmed
12223490
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15077116
uniprot
proteins
pubmed
15122313
uniprot
proteins
pubmed
15241487
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15989957
uniprot
proteins
pubmed
16543145
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17389404
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18987736
uniprot
proteins
pubmed
20562877
uniprot
proteins
pubmed
23024798
uniprot
proteins
pubmed
23055042
uniprot
proteins
pubmed
27013495
uniprot
proteins
pubmed
35063767
uniprot
proteins
pubmed
7682708
uniprot
proteins
pubmed
8790944
uniprot
proteins
pubmed
9671497
uniprot
proteins
sequence_length
350
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria.
uniprot
proteins
transmembrane_region
TRANSMEM 328..348; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins