TM4SF5
entrez
9032
canonical
uniprot
O14894
canonical
ensembl
ENSG00000142484
resolver
ensp
ENSP00000270560
resolver
enst
ENST00000270560
resolver
genesymbol
TM4SF5
resolver
hgnc
HGNC:11857
resolver
uniprot
Q17RW9
resolver
uniprot
Q6IB79
resolver
uniprot_entry
T4S5_HUMAN
resolver
uniprot_sec
Q17RW9
resolver
uniprot_sec
Q6IB79
resolver
amino_acid_sequence
MCTGKCARCVGLSLITLCLVCIVANALLLVPNGETSWTNTNHLSLQVWLMGGFIGGGLMVLCPGIAAVRAGGKGCCGAGCCGNRCRMLRSVFSSAFGVLGAIYCLSVSGAGLRNGPRCLMNGEWGYHFEDTAGAYLLNRTLWDRCEAPPRVVPWNVTLFSLLVAASCLEIVLCGIQLVNATIGVFCGDCRKKQDTPH
uniprot
proteins
function
FUNCTION: Acts as a lysosomal membrane arginine sensor (PubMed:30956113). Forms a complex with MTOR and SLC38A9 on lysosomal membranes in an arginine-regulated manner, leading to arginine efflux which enables the activation of mTORC1 which subsequently leads to RPS6KB1 and EIF4EBP1 phosphorylations (PubMed:30956113). Facilitates cell cycle G1/S phase progression and the translocation of the CDK4-CCND1 complex into the nucleus (PubMed:20399237). CDKN1B and RHOA/ROCK signaling activity are involved in TM4SF5-mediated acceleration of G1/S phase progression (PubMed:20399237). {ECO:0000269|PubMed:20399237, ECO:0000269|PubMed:30956113}.
uniprot
proteins
mass_dalton
20823
uniprot
proteins
mutagenesis
MUTAGEN 124; /note="W->A: Disrupts arginine-binding."; /evidence="ECO:0000269|PubMed:30956113"; MUTAGEN 125; /note="G->A: Disrupts arginine-binding."; /evidence="ECO:0000269|PubMed:30956113"; MUTAGEN 126; /note="Y->S: Disrupts arginine-binding."; /evidence="ECO:0000269|PubMed:30956113"; MUTAGEN 127; /note="H->A: Disrupts arginine-binding."; /evidence="ECO:0000269|PubMed:30956113"; MUTAGEN 128; /note="F->S: Disrupts arginine-binding."; /evidence="ECO:0000269|PubMed:30956113"; MUTAGEN 129; /note="E->A: Disrupts arginine-binding."; /evidence="ECO:0000269|PubMed:30956113
uniprot
proteins
protein_family
L6 tetraspanin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20399237
uniprot
proteins
pubmed
30956113
uniprot
proteins
pubmed
9479038
uniprot
proteins
sequence_length
197
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:30956113}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:30956113}; Multi-pass membrane protein {ECO:0000255}. Note=Localization to cell membrane increases during conditions of arginine depletion and translocation to lysosome membrane seen upon arginine repletion. {ECO:0000269|PubMed:30956113}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..30; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 47..67; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 91..111; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 158..178; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins