BCL7B
entrez
9275
canonical
uniprot
Q9BQE9
canonical
ensembl
ENSG00000106635
resolver
ensp
ENSP00000223368
resolver
ensp
ENSP00000393230
resolver
ensp
ENSP00000411073
resolver
enst
ENST00000455335
resolver
genesymbol
BCL7B
resolver
hgnc
HGNC:1005
resolver
uniprot
A8K226
resolver
uniprot
C9JWD3
resolver
uniprot
D3DXF0
resolver
uniprot
F2Z3H6
resolver
uniprot
O43769
resolver
uniprot
Q13845
resolver
uniprot
Q6ZW75
resolver
uniprot_entry
BCL7B_HUMAN
resolver
uniprot_entry
F2Z3H6_HUMAN
resolver
uniprot_sec
A8K226
resolver
uniprot_sec
C9JWD3
resolver
uniprot_sec
D3DXF0
resolver
uniprot_sec
O43769
resolver
uniprot_sec
Q13845
resolver
uniprot_sec
Q6ZW75
resolver
amino_acid_sequence
MSGRSVRAETRSRAKDDIKKVMAAIEKVRKWEKKWVTVGDTSLRIFKWVPVTDSKEKEKSKSNSSAAREPNGFPSDASANSSLLLEFQDENSNQSSVSDVYQLKVDSSTNSSPSPQQSESLSPAHTSDFRTDDSQPPTLGQEILEEPSLPSSEVADEPPTLTKEEPVPLETQVVEEEEDSGAPPLKRFCVDQPTVPQTASES
uniprot
proteins
disease_involvement
DISEASE: Note=BCL7B is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of BCL7B may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. {ECO:0000269|PubMed:9860302, ECO:0000269|PubMed:9931421}.
uniprot
proteins
function
FUNCTION: Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (PubMed:25569233). Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (PubMed:25569233). May play a role in lung tumor development or progression (By similarity). {ECO:0000250|UniProtKB:Q921K9, ECO:0000269|PubMed:25569233}.
uniprot
proteins
mass_dalton
22195
uniprot
proteins
protein_family
BCL7 family
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25569233
uniprot
proteins
pubmed
8605326
uniprot
proteins
pubmed
9806765
uniprot
proteins
pubmed
9860302
uniprot
proteins
pubmed
9931421
uniprot
proteins
sequence_length
202
uniprot
proteins