Q63690
uniprot
Q63690
canonical
amino_acid_sequence
MDGSGEQLGGGGPTSSEQIMKTGAFLLQGFIQDRAGRMAGETPELTLEQPPQDASTKKLSECLRRIGDELDSNMELQRMIADVDTDSPREVFFRVAADMFADGNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLVWIQDQGGWDGLLSYFGTPTWQTVTIFVAGVLTASLTIWKKMG
uniprot
proteins
function
FUNCTION: Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. {ECO:0000250|UniProtKB:Q07812}.
uniprot
proteins
mass_dalton
21351
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated in the absence of XRCC6/Ku70 (By similarity). Ubiquitinated on Lys-128 and Lys-190. 'Lys-63'-linked polyubiquitin chains on Lys-128 are removed by USP12. {ECO:0000250|UniProtKB:Q07812}.
uniprot
proteins
protein_family
Bcl-2 family
uniprot
proteins
pubmed
15383280
uniprot
proteins
pubmed
7828536
uniprot
proteins
pubmed
8600029
uniprot
proteins
pubmed
8994223
uniprot
proteins
sequence_length
192
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform Alpha]: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q07812}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q07812}. Nucleus {ECO:0000250|UniProtKB:Q07812}. Note=Colocalizes with 14-3-3 proteins in the cytoplasm. Under stress conditions, undergoes a conformation change that causes release from JNK-phosphorylated 14-3-3 proteins and translocation to the mitochondrion membrane (By similarity). {ECO:0000250|UniProtKB:Q07812}.; SUBCELLULAR LOCATION: [Isoform Beta]: Cytoplasm {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform Gamma]: Cytoplasm {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 172..192; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins