TRIM14
entrez
9830
canonical
uniprot
Q14142
canonical
ensembl
ENSG00000106785
resolver
ensp
ENSP00000343990
resolver
ensp
ENSP00000344208
resolver
ensp
ENSP00000539701
resolver
ensp
ENSP00000539704
resolver
ensp
ENSP00000539705
resolver
ensp
ENSP00000661573
resolver
ensp
ENSP00000661574
resolver
genesymbol
TRIM14
resolver
genesymbol_syn
KIAA0129
resolver
hgnc
HGNC:16283
resolver
uniprot
A8K9W0
resolver
uniprot
E7EQC4
resolver
uniprot
F8W956
resolver
uniprot
Q548W9
resolver
uniprot
Q5TBQ8
resolver
uniprot
Q6ZWL7
resolver
uniprot
Q9BRD8
resolver
uniprot
Q9C020
resolver
uniprot_entry
TRI14_HUMAN
resolver
uniprot_sec
A8K9W0
resolver
uniprot_sec
E7EQC4
resolver
uniprot_sec
F8W956
resolver
uniprot_sec
Q548W9
resolver
uniprot_sec
Q5TBQ8
resolver
uniprot_sec
Q6ZWL7
resolver
uniprot_sec
Q9BRD8
resolver
uniprot_sec
Q9C020
resolver
amino_acid_sequence
MAGAATGSRTPGRSELVEGCGWRCPEHGDRVAELFCRRCRRCVCALCPVLGAHRGHPVGLALEAAVHVQKLSQECLKQLAIKKQQHIDNITQIEDATEKLKANAESSKTWLKGKFTELRLLLDEEEALAKKFIDKNTQLTLQVYREQADSCREQLDIMNDLSNRVWSISQEPDPVQRLQAYTATEQEMQQQMSLGELCHPVPLSFEPVKSFFKGLVEAVESTLQTPLDIRLKESINCQLSDPSSTKPGTLLKTSPSPERSLLLKYARTPTLDPDTMHARLRLSADRLTVRCGLLGSLGPVPVLRFDALWQVLARDCFATGRHYWEVDVQEAGAGWWVGAAYASLRRRGASAAARLGCNRQSWCLKRYDLEYWAFHDGQRSRLRPRDDLDRLGVFLDYEAGVLAFYDVTGGMSHLHTFRATFQEPLYPALRLWEGAISIPRLP
uniprot
proteins
function
FUNCTION: Plays an essential role in the innate immune defense against viruses and bacteria (PubMed:30150992, PubMed:32404352). Promotes the 'Lys-48'-linked ubiquitination and subsequent degradation of hepatitis C virus NS5A leading to the inhibition of viral replication (PubMed:27578425). Also plays a role in the inhibition of ebolavirus infection by enhancing IFN-beta and NF-kappa-B activation after binding to the viral protein NP (PubMed:37562033). Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways (PubMed:24379373). Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation (PubMed:27666593). Acts as a scaffold between TBK1 and STAT3 to promote phosphorylation of STAT3 and resolve interferon-stimulated gene (ISG) expression (PubMed:32404352). Inhibits the transcriptional activity of SPI1 in a dose-dependent manner (By similarity). Also inhibits OPTN-mediated selective autophagic degradation of KDM4D and thereby negatively regulates H3K9me2 and H3K9me3. Mechanistically, recruits USP14 to remove the 'Lys-63'-linked ubiquitination of KDM4D, preventing its recognition by OPTN and subsequent degradation (PubMed:35145029). {ECO:0000250|UniProtKB:Q8BVW3, ECO:0000269|PubMed:24379373, ECO:0000269|PubMed:27578425, ECO:0000269|PubMed:27666593, ECO:0000269|PubMed:29053956, ECO:0000269|PubMed:30150992, ECO:0000269|PubMed:32404352, ECO:0000269|PubMed:35145029, ECO:0000269|PubMed:37562033}.
uniprot
proteins
mass_dalton
49773
uniprot
proteins
mutagenesis
MUTAGEN 365; /note="K->R: More than 50% loss of interaction with MAVS. However it has equal potency in inhibiting HCV replication that the wild type."; /evidence="ECO:0000269|PubMed:24379373, ECO:0000269|PubMed:27578425
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated (PubMed:24379373). Undergoes 'Lys-63'-linked polyubiquitination; this modification allows IKBKG/NEMO recruitment to MAVS. Undergoes 'Lys-48'-linked polyubiquitination by RNF125; this modification mediates its degradation via the ubiquitin-proteasome pathway (PubMed:28476934). {ECO:0000269|PubMed:24379373, ECO:0000269|PubMed:28476934}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
11331580
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22711689
uniprot
proteins
pubmed
24379373
uniprot
proteins
pubmed
27578425
uniprot
proteins
pubmed
27666593
uniprot
proteins
pubmed
28476934
uniprot
proteins
pubmed
29053956
uniprot
proteins
pubmed
30150992
uniprot
proteins
pubmed
32404352
uniprot
proteins
pubmed
35145029
uniprot
proteins
pubmed
37562033
uniprot
proteins
pubmed
8590280
uniprot
proteins
sequence_length
442
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:24379373, ECO:0000269|PubMed:28476934, ECO:0000269|PubMed:29053956}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:32404352}. Nucleus {ECO:0000269|PubMed:35145029}.
uniprot
proteins