CORO1A
entrez
11151
canonical
uniprot
P31146
canonical
ensembl
ENSG00000102879
resolver
ensp
ENSP00000219150
resolver
ensp
ENSP00000455552
resolver
ensp
ENSP00000561561
resolver
ensp
ENSP00000561562
resolver
ensp
ENSP00000561563
resolver
ensp
ENSP00000561565
resolver
ensp
ENSP00000561566
resolver
ensp
ENSP00000561567
resolver
ensp
ENSP00000561568
resolver
ensp
ENSP00000561569
resolver
ensp
ENSP00000561570
resolver
ensp
ENSP00000599022
resolver
enst
ENST00000219150
resolver
enst
ENST00000570045
resolver
enst
ENST00000891502
resolver
enst
ENST00000891503
resolver
enst
ENST00000891504
resolver
enst
ENST00000891506
resolver
enst
ENST00000891507
resolver
enst
ENST00000891508
resolver
enst
ENST00000891509
resolver
enst
ENST00000891510
resolver
enst
ENST00000891511
resolver
enst
ENST00000928963
resolver
genesymbol
CORO1A
resolver
genesymbol_syn
CORO1
resolver
hgnc
HGNC:2252
resolver
uniprot
B2RBL1
resolver
uniprot
Q2YD73
resolver
uniprot_entry
COR1A_HUMAN
resolver
uniprot_sec
B2RBL1
resolver
uniprot_sec
Q2YD73
resolver
amino_acid_sequence
MSRQVVRSSKFRHVFGQPAKADQCYEDVRVSQTTWDSGFCAVNPKFVALICEASGGGAFLVLPLGKTGRVDKNAPTVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLMLPLREPVVTLEGHTKRVGIVAWHTTAQNVLLSAGCDNVIMVWDVGTGAAMLTLGPEVHPDTIYSVDWSRDGGLICTSCRDKRVRIIEPRKGTVVAEKDRPHEGTRPVRAVFVSEGKILTTGFSRMSERQVALWDTKHLEEPLSLQELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEAPFLHYLSMFSSKESQRGMGYMPKRGLEVNKCEIARFYKLHERRCEPIAMTVPRKSDLFQEDLYPPTAGPDPALTAEEWLGGRDAGPLLISLKDGYVPPKSRELRVNRGLDTGRRRAAPEASGTPSSDAVSRLEEEMRKLQATVQELQKRLDRLEETVQAK
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency 8 with lymphoproliferation (IMD8) [MIM:615401]: A disease of the immune system leading to recurrent infections, and characterized by CD4+ T-cells lymphopenia. Patients can develop B-cell lymphoproliferation associated with Epstein-Barr virus infection. {ECO:0000269|PubMed:19097825, ECO:0000269|PubMed:23522482}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes. {ECO:0000269|PubMed:10338208}.
uniprot
proteins
mass_dalton
51026
uniprot
proteins
post_translational_modification
PTM: phosphorylation at Thr-412 by PKC strongly down-regulates the association with actin. {ECO:0000269|PubMed:23100250}.; PTM: Polyubiquitinated by RNF128 with 'Lys-48'-linked chains, leading to proteasomal degradation. {ECO:0000269|PubMed:22016387}.
uniprot
proteins
protein_family
WD repeat coronin family
uniprot
proteins
pubmed
10338208
uniprot
proteins
pubmed
1286667
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19097825
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22016387
uniprot
proteins
pubmed
23100250
uniprot
proteins
pubmed
23522482
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
7758584
uniprot
proteins
sequence_length
461
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}. Note=In non-infected macrophages, associated with the cortical microtubule network. In mycobacteria-infected macrophages, becomes progressively relocalized and retained around the mycobacterial phagosomes. Retention on the phagosomal membrane is strictly dependent on mycobacterial viability and not due to impaired acidification (By similarity). {ECO:0000250}.
uniprot
proteins