MAGEC2
entrez
51438
canonical
uniprot
Q9UBF1
canonical
ensembl
ENSG00000046774
resolver
ensp
ENSP00000354660
resolver
enst
ENST00000247452
resolver
genesymbol
MAGEC2
resolver
genesymbol_syn
HCA587
resolver
genesymbol_syn
MAGEE1
resolver
hgnc
HGNC:13574
resolver
uniprot
Q5JZ00
resolver
uniprot
Q96D45
resolver
uniprot
Q9P1M6
resolver
uniprot
Q9P1M7
resolver
uniprot_entry
MAGC2_HUMAN
resolver
uniprot_sec
Q5JZ00
resolver
uniprot_sec
Q96D45
resolver
uniprot_sec
Q9P1M6
resolver
uniprot_sec
Q9P1M7
resolver
amino_acid_sequence
MPPVPGVPFRNVDNDSPTSVELEDWVDAQHPTDEEEEEASSASSTLYLVFSPSSFSTSSSLILGGPEEEEVPSGVIPNLTESIPSSPPQGPPQGPSQSPLSSCCSSFSWSSFSEESSSQKGEDTGTCQGLPDSESSFTYTLDEKVAELVEFLLLKYEAEEPVTEAEMLMIVIKYKDYFPVILKRAREFMELLFGLALIEVGPDHFCVFANTVGLTDEGSDDEGMPENSLLIIILSVIFIKGNCASEEVIWEVLNAVGVYAGREHFVYGEPRELLTKVWVQGHYLEYREVPHSSPPYYEFLWGPRAHSESIKKKVLEFLAKLNNTVPSSFPSWYKDALKDVEERVQATIDTADDATVMASESLSVMSSNVSFSE
uniprot
proteins
function
FUNCTION: Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex. {ECO:0000269|PubMed:20864041}.
uniprot
proteins
mass_dalton
41163
uniprot
proteins
mutagenesis
MUTAGEN 152..153; /note="LL->AA: Decreases interaction with TRIM28, abolishes in vitro ubiquitination of TP53."; /evidence="ECO:0000269|PubMed:20864041
uniprot
proteins
pubmed
10699956
uniprot
proteins
pubmed
10861452
uniprot
proteins
pubmed
12097419
uniprot
proteins
pubmed
12920247
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17942928
uniprot
proteins
pubmed
20864041
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12920247}. Nucleus {ECO:0000269|PubMed:12920247}. Note=Nuclear in germ cells. Cytoplasmic in well-differentiated hepatocellular carcinoma, nuclear in moderately- and poorly-differentiated hepatocellular carcinoma.
uniprot
proteins