Slc5a6
entrez
330064
canonical
uniprot
Q5U4D8
canonical
ensembl
ENSMUSG00000006641
resolver
ensp
ENSMUSP00000079291
resolver
ensp
ENSMUSP00000110316
resolver
ensp
ENSMUSP00000143938
resolver
ensp
ENSMUSP00000143993
resolver
enst
ENSMUST00000080431
resolver
enst
ENSMUST00000114668
resolver
enst
ENSMUST00000202520
resolver
enst
ENSMUST00000202556
resolver
genesymbol
Slc5a6
resolver
uniprot
Q3TY45
resolver
uniprot
Q8BTU3
resolver
uniprot_entry
Q3TY45_MOUSE
resolver
uniprot_entry
SC5A6_MOUSE
resolver
uniprot_sec
Q8BTU3
resolver
amino_acid_sequence
MSVASTAAPFHTTSGSSGAISTFSVVDYVVFGLLLVLSLVIGLYHACRGWGHHTVGELLMADRKMGCLPVALSLLATFQSAVAILGAPAEIFRFGTQYWFLGCSYFLGLLIPAHIFIPVFYRLHLTSAYEYLELRFNKAVRICGTVTFIFQMVIYMGVALYAPSLALNAVTGFDLWLSVLALGIVCNIYTALGGLKAVIWTDVFQTLVMFLGQLVVIIVGAARVGGLGHVWNVTSQHGLISGINLDPDPFVRHTFWTLAFGGVFMMLSLYGVNQAQVQRYLSSHSERAAVLSCYAVFPCQQVALCMSCLIGLVMFAYYNMYSMSPELKQAAPDQLVLYFVMDLLKDMPGLPGLFVACLFSGSLSTISSAFNSLATVTMEDLIQPWFPQLTETRAIMLSRGLAFAYGLVCLGMAYISSHLGSVLQAALSIFGMVGGPLLGLFCLGLFFPCANPLGAIVGLLTGLTMAFWIGIGSIVSRMSSAVAPPPLNGSSSFLPANVTVAAVTTVMPSTLSKPTGLQHFYSLSYLWYSAHNSTTVIVVGLIVSLLTGGMRGRSLNPGTIYPVLPKLLALLPLSCQKRLCWRSHSQDIPVIPNLFPEKMRNGVLQDSTDKERMAEDGLVHQPCSPTYVVQETSL
uniprot
proteins
function
FUNCTION: Sodium-dependent multivitamin transporter that mediates the electrogenic transport of pantothenate, biotin, lipoate and iodide (PubMed:23104561). Functions as a Na(+)-coupled substrate symporter where the stoichiometry of Na(+):substrate is 2:1, creating an electrochemical Na(+) gradient used as driving force for substrate uptake (By similarity). Required for biotin and pantothenate uptake in the intestine across the brush border membrane (PubMed:23104561). Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin (PubMed:27492331). Contributes to the luminal uptake of biotin and pantothenate into the brain across the blood-brain barrier (By similarity). {ECO:0000250|UniProtKB:Q9Y289, ECO:0000269|PubMed:23104561, ECO:0000269|PubMed:27492331}.
uniprot
proteins
mass_dalton
68511
uniprot
proteins
protein_family
Sodium:solute symporter (SSF) (TC 2.A.21) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23104561
uniprot
proteins
pubmed
27492331
uniprot
proteins
pubmed
28052864
uniprot
proteins
sequence_length
634
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9Y289}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q9Y289}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..43; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 65..85; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 100..120; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 142..162; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 175..195; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 207..227; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 255..275; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 295..315; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 350..370; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 403..423; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 427..447; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 455..475; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 526..546; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins