Mme
entrez
17380
canonical
uniprot
Q61391
canonical
ensembl
ENSMUSG00000027820
resolver
ensp
ENSMUSP00000029400
resolver
ensp
ENSMUSP00000141544
resolver
ensp
ENSMUSP00000142205
resolver
ensp
ENSMUSP00000327507
resolver
enst
ENSMUST00000029400
resolver
enst
ENSMUST00000194134
resolver
enst
ENSMUST00000194150
resolver
genesymbol
Mme
resolver
uniprot
Q6NXX5
resolver
uniprot
Q8K251
resolver
uniprot_entry
NEP_MOUSE
resolver
uniprot_sec
Q6NXX5
resolver
uniprot_sec
Q8K251
resolver
amino_acid_sequence
MGRSESQMDITDINAPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDASVEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKDVLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLKLLPDIYGWPVASDNWDQTYGTSWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEQSLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLYNKMTLAKLQNNFSLEVNGKSFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERIGYPDDIISNENKLNNEYLELNYREDEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSAQQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSANNFKDQSQCMVYQYGNFSWDLAGGQHLNGINTLGENIADNGGIGQAYRAYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPERKCRVW
uniprot
proteins
ec_number
3.4.24.11
uniprot
proteins
function
FUNCTION: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (By similarity). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (By similarity). Catalyzes cleavage of bradykinin, substance P and neurotensin peptides (By similarity). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (By similarity). Involved in the degradation of the atrial natriuretic factor (ANF) (By similarity). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573). {ECO:0000250|UniProtKB:P08473, ECO:0000269|PubMed:20876573}.
uniprot
proteins
mass_dalton
85702
uniprot
proteins
post_translational_modification
PTM: Myristoylation is a determinant of membrane targeting. {ECO:0000250|UniProtKB:P08473}.; PTM: Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity. {ECO:0000250|UniProtKB:P08473}.
uniprot
proteins
protein_family
Peptidase M13 family
uniprot
proteins
pubmed
1374101
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
20876573
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27588448
uniprot
proteins
sequence_length
750
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P08473}; Single-pass type II membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 29..51; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins