Cenpt
entrez
307805
canonical
uniprot
Q561R1
canonical
ensembl
ENSRNOG00000024178
resolver
ensembl
ENSRNOG00055017988
resolver
ensembl
ENSRNOG00060011435
resolver
ensp
ENSRNOP00000029297
resolver
ensp
ENSRNOP00055024529
resolver
ensp
ENSRNOP00060015165
resolver
enst
ENSRNOT00000036702
resolver
enst
ENSRNOT00055030476
resolver
enst
ENSRNOT00060019346
resolver
genesymbol
Cenpt
resolver
uniprot_entry
CENPT_RAT
resolver
amino_acid_sequence
MADLSSPDGDPTIRTLLRHVLDTADSHTPRRRQSTQTNPQRRRSQTPYSKRQGSQRKTSTRKHSHGTGSVGRLARVQGHGHLEEQTPRTLLQNILLTAPESSTVMPNPVVKPAQVPEVARPSRRGSSRGSLELQLPELDPPSTLAPGLKAPGKRKQKLRLSVFQQEVNQQLPLPQEQRGAADGSSLASSFNLSFVPSVQPQTVDRPGLARRRPVRRPVNIGAFLQNLENKSLTSALPGDSHRTPVAALPTDVVFEDTQPFSQPLAGCSLSVHHSLPNPSQTEVEDAERVVGPRTPSTGTRPQSQMSRAGFGASPLPFSEPQPQSPELREAVGSKEAEEPKDLEGSSGDEETSGMPASRELSSSAQDLLLAEEPHQLFEPPPSPGVAAVSSESVPAKLPSRTRTAQPRHHQDPYKAGLSHYVKLFSFHTKMPVEKAALEMVEKCLDEYFQRLCNDLEVFAAHAGRKTVKPKDLELLMRRQGLVTDQVSLHVLVERYLPLEYRQQLIPCAFRGNSVFPAQ
uniprot
proteins
function
FUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. {ECO:0000250|UniProtKB:Q96BT3}.
uniprot
proteins
mass_dalton
56861
uniprot
proteins
post_translational_modification
PTM: Dynamically phosphorylated during the cell cycle. Phosphorylated during G2 phase, metaphase and anaphase, but not during telophase or G1 phase. {ECO:0000250|UniProtKB:Q96BT3}.
uniprot
proteins
protein_family
CENP-T/CNN1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
518
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96BT3}. Chromosome, centromere {ECO:0000250|UniProtKB:Q96BT3}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q96BT3}. Note=Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis. Localizes to the inner kinetochore, and may connect it to the outer kinetochore via its N-terminus. {ECO:0000250|UniProtKB:Q96BT3}.
uniprot
proteins