Kcna3
entrez
29731
canonical
uniprot
P15384
canonical
ensembl
ENSRNOG00000062002
resolver
ensembl
ENSRNOG00055020274
resolver
ensembl
ENSRNOG00060029881
resolver
ensembl
ENSRNOG00065022921
resolver
ensp
ENSRNOP00000075761
resolver
ensp
ENSRNOP00000096474
resolver
ensp
ENSRNOP00000100281
resolver
ensp
ENSRNOP00055028042
resolver
ensp
ENSRNOP00055028047
resolver
ensp
ENSRNOP00060043147
resolver
ensp
ENSRNOP00060043158
resolver
ensp
ENSRNOP00065031802
resolver
ensp
ENSRNOP00065031811
resolver
enst
ENSRNOT00000092240
resolver
enst
ENSRNOT00000108050
resolver
enst
ENSRNOT00000139818
resolver
enst
ENSRNOT00055034614
resolver
enst
ENSRNOT00055034620
resolver
enst
ENSRNOT00060051882
resolver
enst
ENSRNOT00060051896
resolver
enst
ENSRNOT00065039148
resolver
enst
ENSRNOT00065039159
resolver
genesymbol
Kcna3
resolver
uniprot_entry
KCNA3_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activity is up-regulated by JAK2. {ECO:0000250|UniProtKB:P16390}.
uniprot
proteins
amino_acid_sequence
MTVVPGDHLLEPEAAGGGGGDPPQGGCVSGGGCDRYEPLPPALPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASPSQDVFEAANNSTSGASSGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPSSGFNSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV
uniprot
proteins
function
FUNCTION: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. {ECO:0000269|PubMed:19773357, ECO:0000269|PubMed:2351830, ECO:0000269|PubMed:2361015, ECO:0000269|PubMed:2555158, ECO:0000269|PubMed:27802162, ECO:0000269|PubMed:32370164, ECO:0000269|PubMed:8774427}.
uniprot
proteins
mass_dalton
58425
uniprot
proteins
mutagenesis
MUTAGEN 449; /note="Y->F: Loss of phosphorylation."; /evidence="ECO:0000269|PubMed:8774427
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Tyr-449 inhibits its channel activity. {ECO:0000269|PubMed:8774427}.; PTM: N-glycosylation promotes the cell surface expression. {ECO:0000269|PubMed:22613618}.
uniprot
proteins
protein_family
A (Shaker) (TC 1.A.1.2) subfamily
uniprot
proteins
protein_family
Kv1.3/KCNA3 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
19773357
uniprot
proteins
pubmed
22613618
uniprot
proteins
pubmed
2351830
uniprot
proteins
pubmed
2361015
uniprot
proteins
pubmed
2555158
uniprot
proteins
pubmed
27802162
uniprot
proteins
pubmed
32370164
uniprot
proteins
pubmed
7477295
uniprot
proteins
pubmed
8774427
uniprot
proteins
sequence_length
525
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19773357, ECO:0000269|PubMed:22613618, ECO:0000269|PubMed:27802162, ECO:0000269|PubMed:32370164}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 185..203; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 245..266; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 278..298; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 313..331; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 348..367; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 409..431; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins