LIMA1
entrez
51474
canonical
uniprot
Q9UHB6
canonical
ensembl
ENSG00000050405
resolver
ensp
ENSP00000340184
resolver
ensp
ENSP00000378400
resolver
ensp
ENSP00000448706
resolver
ensp
ENSP00000448779
resolver
ensp
ENSP00000542718
resolver
ensp
ENSP00000542724
resolver
ensp
ENSP00000626892
resolver
genesymbol
LIMA1
resolver
genesymbol_syn
EPLIN
resolver
genesymbol_syn
SREBP3
resolver
hgnc
HGNC:24636
resolver
uniprot
B2RB09
resolver
uniprot
Q2TAN7
resolver
uniprot
Q59FE8
resolver
uniprot
Q9BVF2
resolver
uniprot
Q9H8J1
resolver
uniprot
Q9HBN5
resolver
uniprot
Q9NX96
resolver
uniprot
Q9NXC3
resolver
uniprot
Q9NXU6
resolver
uniprot
Q9P0H8
resolver
uniprot
Q9UHB5
resolver
uniprot_entry
LIMA1_HUMAN
resolver
uniprot_sec
B2RB09
resolver
uniprot_sec
Q2TAN7
resolver
uniprot_sec
Q59FE8
resolver
uniprot_sec
Q9BVF2
resolver
uniprot_sec
Q9H8J1
resolver
uniprot_sec
Q9HBN5
resolver
uniprot_sec
Q9NX96
resolver
uniprot_sec
Q9NXC3
resolver
uniprot_sec
Q9NXU6
resolver
uniprot_sec
Q9P0H8
resolver
uniprot_sec
Q9UHB5
resolver
amino_acid_sequence
MESSPFNRRQWTSLSLRVTAKELSLVNKNKSSAIVEIFSKYQKAAEETNMEKKRSNTENLSQHFRKGTLTVLKKKWENPGLGAESHTDSLRNSSTEIRHRADHPPAEVTSHAASGAKADQEEQIHPRSRLRSPPEALVQGRYPHIKDGEDLKDHSTESKKMENCLGESRHEVEKSEISENTDASGKIEKYNVPLNRLKMMFEKGEPTQTKILRAQSRSASGRKISENSYSLDDLEIGPGQLSSSTFDSEKNESRRNLELPRLSETSIKDRMAKYQAAVSKQSSSTNYTNELKASGGEIKIHKMEQKENVPPGPEVCITHQEGEKISANENSLAVRSTPAEDDSRDSQVKSEVQQPVHPKPLSPDSRASSLSESSPPKAMKKFQAPARETCVECQKTVYPMERLLANQQVFHISCFRCSYCNNKLSLGTYASLHGRIYCKPHFNQLFKSKGNYDEGFGHRPHKDLWASKNENEEILERPAQLANARETPHSPGVEDAPIAKVGVLAASMEAKASSQQEKEDKPAETKKLRIAWPPPTELGSSGSALEEGIKMSKPKWPPEDEISKPEVPEDVDLDLKKLRRSSSLKERSRPFTVAASFQSTSVKSPKTVSPPIRKGWSMSEQSEESVGGRVAERKQVENAKASKKNGNVGKTTWQNKESKGETGKRSKEGHSLEMENENLVENGADSDEDDNSFLKQQSPQEPKSLNWSSFVDNTFAEEFTTQNQKSQDVELWEGEVVKELSVEEQIKRNRYYDEDEDEE
uniprot
proteins
function
FUNCTION: Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (PubMed:12566430, PubMed:33999101). Acts as a negative regulator of primary cilium formation (PubMed:32496561). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:12566430, ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}.
uniprot
proteins
mass_dalton
85226
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the ECS(RAB40B) complex leading to its degradation. {ECO:0000269|PubMed:33999101}.; PTM: Phosphorylation of the C-terminal region by MAPK1/MAPK3 reduces its association with F-actin and contributes to actin filament reorganization and enhances cell motility. {ECO:0000250|UniProtKB:Q9ERG0}.
uniprot
proteins
pubmed
10618726
uniprot
proteins
pubmed
10806352
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
11256614
uniprot
proteins
pubmed
12566430
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24694988
uniprot
proteins
pubmed
29880681
uniprot
proteins
pubmed
32496561
uniprot
proteins
pubmed
33999101
uniprot
proteins
sequence_length
759
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cell junction, focal adhesion {ECO:0000269|PubMed:10618726, ECO:0000269|PubMed:24694988}. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:10618726}. Cell membrane {ECO:0000250|UniProtKB:Q9ERG0}. Cell projection, ruffle {ECO:0000269|PubMed:32496561, ECO:0000269|PubMed:33999101}. Cell projection, lamellipodium {ECO:0000269|PubMed:33999101}. Note=Expressed in the brush border membrane of the small intestine and colocalizes with NPC1L1 and MYO5B (PubMed:29880681). Colocalizes with PXN at focal adhesions in mesangial cells (PubMed:24694988). Colocalizes with actin stress fibers in quiescent cells. PDGF stimulation induced disassembly of stress fibers and formation of peripheral and dorsal ruffles, where LIMA1 is relocalized (By similarity). Localized at the lamellipodia, just behind lamellipodia actin ruffles (PubMed:33999101). {ECO:0000250|UniProtKB:Q9ERG0, ECO:0000269|PubMed:24694988, ECO:0000269|PubMed:29880681, ECO:0000269|PubMed:33999101}.
uniprot
proteins