Cyrib
entrez
223601
canonical
uniprot
Q921M7
canonical
ensembl
ENSMUSG00000022378
resolver
ensp
ENSMUSP00000066359
resolver
ensp
ENSMUSP00000132486
resolver
ensp
ENSMUSP00000154320
resolver
ensp
ENSMUSP00000288273
resolver
ensp
ENSMUSP00000288278
resolver
ensp
ENSMUSP00000288285
resolver
ensp
ENSMUSP00000288309
resolver
ensp
ENSMUSP00000288311
resolver
ensp
ENSMUSP00000288319
resolver
ensp
ENSMUSP00000288321
resolver
ensp
ENSMUSP00000337032
resolver
enst
ENSMUST00000063838
resolver
enst
ENSMUST00000164532
resolver
enst
ENSMUST00000228226
resolver
genesymbol
Cyrib
resolver
genesymbol_syn
Cyri
resolver
genesymbol_syn
Fam49b
resolver
uniprot_entry
CYRIB_MOUSE
resolver
amino_acid_sequence
MGNLLKVLTCTDLEQGPNFFLDFENAQPTESEKEIYNQVNVVLKDAEGILEDLQSYRGAGHEIREAIQHPADEKLQEKAWGAVVPLVGKLKKFYEFSQRLEAALRGLLGALTSTPYSPTQHLEREQALAKQFAEILHFTLRFDELKMTNPAIQNDFSYYRRTLSRMRINNVPAEGENEVNNELANRMSLFYAEATPMLKTLSDATTKFVSENKNLPIENTTDCLSTMASVCRVMLETPEYRSRFTNEETVSFCLRVMVGVIILYDHVHPVGAFAKTSKIDMKGCIKVLKDQPPNSVEGLLNALRYTTKHLNDETTSKQIRSMLQ
uniprot
proteins
function
FUNCTION: Negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling (PubMed:31285585). Regulates chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Limits Rac1 mediated activation of the Scar/WAVE complex, focuses protrusion signals and regulates pseudopod complexity by inhibiting Scar/WAVE-induced actin polymerization (By similarity). Protects against Salmonella bacterial infection. Attenuates processes such as macropinocytosis, phagocytosis and cell migration and restrict sopE-mediated bacterial entry (PubMed:31285585). Also restricts infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes (PubMed:31285585). Involved in the regulation of mitochondrial dynamics and oxidative stress (PubMed:29059164). {ECO:0000250|UniProtKB:Q9NUQ9, ECO:0000269|PubMed:29059164, ECO:0000269|PubMed:31285585}.
uniprot
proteins
mass_dalton
36776
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated at Lys-74 upon Salmonella bacterial infection. {ECO:0000250|UniProtKB:Q9NUQ9}.
uniprot
proteins
protein_family
CYRI family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29059164
uniprot
proteins
pubmed
31285585
uniprot
proteins
sequence_length
324
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9NUQ9}; Lipid-anchor {ECO:0000250|UniProtKB:Q9NUQ9}. Mitochondrion {ECO:0000250|UniProtKB:Q9NUQ9}.
uniprot
proteins