Ppm1l
entrez
242083
canonical
uniprot
Q8BHN0
canonical
ensembl
ENSMUSG00000027784
resolver
ensp
ENSMUSP00000029355
resolver
genesymbol
Ppm1l
resolver
genesymbol_syn
Kiaa4175
resolver
uniprot
Q3UGL2
resolver
uniprot
Q810H0
resolver
uniprot
Q8C021
resolver
uniprot
Q8C1D5
resolver
uniprot
Q9Z0T1
resolver
uniprot_entry
PPM1L_MOUSE
resolver
uniprot_sec
Q3UGL2
resolver
uniprot_sec
Q810H0
resolver
uniprot_sec
Q8C021
resolver
uniprot_sec
Q8C1D5
resolver
uniprot_sec
Q9Z0T1
resolver
amino_acid_sequence
MIEDTMTLLSLLGRIMRYFLLRPETLFLLCISLALWSYFFHTDEVKTIVKSSRDAVKMVKGKVAEIMQNDRLGGLDVLEAEFSKTWEFKSHNVAVYSIQGRRDHMEDRFEVLTDLANKTHPSIFGIFDGHGGETAAEYVKSRLPEALKQHLQDYEKDKENSVLTYQTILEQQILSIDREMLEKLTVSYDEAGTTCLIALLSDKDLTVANVGDSRGVLCDKDGNAIPLSHDHKPYQLKERKRIKRAGGFISFNGSWRVQGILAMSRSLGDYPLKNLNVVIPDPDILTFDLDKLQPEFMILASDGLWDAFSNEEAVRFIKERLDEPHFGAKSIVLQSFYRGCPDNITVMVVKFRNSSKTEEH
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6. {ECO:0000269|PubMed:12556533}.
uniprot
proteins
mass_dalton
41049
uniprot
proteins
mutagenesis
MUTAGEN 130; /note="H->L: Abolishes phosphatase activity."; /evidence="ECO:0000269|PubMed:12556533"; MUTAGEN 239; /note="R->G: Slightly abolishes phosphatase activity."; /evidence="ECO:0000269|PubMed:12556533"; MUTAGEN 241; /note="R->G: Abolishes phosphatase activity."; /evidence="ECO:0000269|PubMed:12556533"; MUTAGEN 265; /note="R->A: Abolishes phosphatase activity."; /evidence="ECO:0000269|PubMed:12556533"; MUTAGEN 302; /note="D->A: Abolishes phosphatase activity, prevents MAP3K7/TAK1 phosphorylation in vitro, does not abolish interaction with MAP3K7/TAK1, found in a complex with MAP3K7/TAK1, MAP2K4 or MAP2K6 and enhances the association between MAP3K7/TAK1, MAP2K4 or MAP2K6."; /evidence="ECO:0000269|PubMed:12556533
uniprot
proteins
protein_family
PP2C family
uniprot
proteins
pubmed
12556533
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17456047
uniprot
proteins
pubmed
18344982
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
360
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 26..42; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins