Dpep3
entrez
71854
canonical
uniprot
Q9DA79
canonical
ensembl
ENSMUSG00000031898
resolver
ensp
ENSMUSP00000034371
resolver
enst
ENSMUST00000034371
resolver
genesymbol
Dpep3
resolver
genesymbol_syn
Mbd3
resolver
uniprot_entry
DPEP3_MOUSE
resolver
amino_acid_sequence
MQPAGLEGPRALGLRPLGHRLSLLGVLLLVPSLWVTCTLTTPSPSSAPTTPEASNATTAPGIPNDTATSGVTSDPRLREQALALMRDFPLVDGHNDLPLLLRELFQNQLQDVNLRNFTRGQTNLDRLRDGLVGAQFWSAYIPCQTQDRDAVRLALEQIDLIRRMCSAYPELELVTSADGLNNTQKLACLIGVEGGHSLDTSLAVLRSFYELGVRYLTLTFTCSTPWAESATKFRHHFYTNISGLTSFGEKVVEEMNRLGMMIDLSHASDTLVKQTLEVSQAPVIFSHSAARSVCDNLLNIPDDILQLLKKNGGIVMVTLSMGVLQCSLFANVSTVADHFDHIRTVIGSEFIGIGGSYDGSGRFPQGLEDVSTYPVLIEELLSRGWDERELQGVLRGNLLRVFRQVEQVREKSLGQSPVEVKFPERQQSNTCHSHLLPQPQEDQHQDTHLKVTKLPNILQRASKAPPHPLPGLMATLTSLALILWLCCSGHRAV
uniprot
proteins
function
FUNCTION: Lacks dipeptidase activity and is unable to hydrolyze cystinyl-bis-glycine (PubMed:32325220). The absence of activity may be due to the inability of serine (instead of aspartate found in DPEP1/2) at position 356 to function as the acid/base catalyst and activate the nucleophilic water/hydroxide (PubMed:32325220). Does not hydrolyze leukotriene D4 (LTD4) into leukotriene E4 (LTE4) (PubMed:12738806). Does not hydrolyze the beta-lactam antibiotic imipenem (By similarity). {ECO:0000250|UniProtKB:Q9H4B8, ECO:0000269|PubMed:12738806, ECO:0000269|PubMed:32325220}.
uniprot
proteins
mass_dalton
54247
uniprot
proteins
protein_family
Metallo-dependent hydrolases superfamily
uniprot
proteins
protein_family
Peptidase M19 family
uniprot
proteins
pubmed
12738806
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20339383
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21724266
uniprot
proteins
pubmed
31212048
uniprot
proteins
pubmed
32325220
uniprot
proteins
sequence_length
493
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:12738806}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:12738806}.
uniprot
proteins