Ccnd3
entrez
12445
canonical
uniprot
P30282
canonical
ensembl
ENSMUSG00000034165
resolver
ensp
ENSMUSP00000040488
resolver
ensp
ENSMUSP00000126141
resolver
ensp
ENSMUSP00000138091
resolver
ensp
ENSMUSP00000138220
resolver
ensp
ENSMUSP00000138458
resolver
ensp
ENSMUSP00000138640
resolver
enst
ENSMUST00000037333
resolver
enst
ENSMUST00000171031
resolver
enst
ENSMUST00000182209
resolver
enst
ENSMUST00000182539
resolver
enst
ENSMUST00000183044
resolver
enst
ENSMUST00000183177
resolver
genesymbol
Ccnd3
resolver
genesymbol_syn
Cyl-3
resolver
uniprot
Q3TSW4
resolver
uniprot
Q3TWY0
resolver
uniprot
Q62391
resolver
uniprot
Q99KP2
resolver
uniprot
S4R216
resolver
uniprot_entry
CCND3_MOUSE
resolver
uniprot_entry
Q3TSW4_MOUSE
resolver
uniprot_entry
Q3TWY0_MOUSE
resolver
uniprot_entry
S4R216_MOUSE
resolver
uniprot_sec
Q62391
resolver
uniprot_sec
Q99KP2
resolver
amino_acid_sequence
MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQKEIKPHMRKMLAYWMLEVCEEQRCEEDVFPLAMNYLDRYLSCVPTRKAQLQLLGTVCLLLASKLRETTPLTIEKLCIYTDQAVAPWQLREWEVLVLGKLKWDLAAVIAHDFLALILHRLSLPSDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVLGLGACSMSADELTELLAGITGTEVDCLRACQEQIEAALRESLREAAQTAPSPVPKAPRGSSSQGPSQTSTPTDVTAIHL
uniprot
proteins
function
FUNCTION: Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Shows transcriptional coactivator activity with ATF5 independently of CDK4. {ECO:0000250|UniProtKB:P30281}.
uniprot
proteins
mass_dalton
32411
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-283 by MAP kinases is required for ubiquitination and degradation by the DCX(AMBRA1) complex. {ECO:0000250|UniProtKB:P24385}.; PTM: Ubiquitinated by the DCX(AMBRA1) complex during the transition from G1 to S cell phase, leading to its degradation: ubiquitination is dependent on Thr-283 phosphorylation (PubMed:33854232, PubMed:33854235). The DCX(AMBRA1) complex represents the major regulator of CCND3 stability during the G1/S transition (PubMed:33854232, PubMed:33854235). Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation (By similarity). {ECO:0000250|UniProtKB:P30281, ECO:0000269|PubMed:33854232, ECO:0000269|PubMed:33854235}.
uniprot
proteins
protein_family
Cyclin D subfamily
uniprot
proteins
protein_family
Cyclin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1827757
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
33854232
uniprot
proteins
pubmed
33854235
uniprot
proteins
pubmed
8661116
uniprot
proteins
sequence_length
292
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P30281}. Cytoplasm {ECO:0000250|UniProtKB:P30281}.
uniprot
proteins