PROK1
entrez
84432
canonical
uniprot
P58294
canonical
ensembl
ENSG00000143125
resolver
ensp
ENSP00000271331
resolver
enst
ENST00000271331
resolver
genesymbol
PROK1
resolver
hgnc
HGNC:18454
resolver
uniprot
Q5VWD4
resolver
uniprot
Q8TC69
resolver
uniprot_entry
PROK1_HUMAN
resolver
uniprot_sec
Q5VWD4
resolver
uniprot_sec
Q8TC69
resolver
amino_acid_sequence
MRGATRVSIMLLLVTVSDCAVITGACERDVQCGAGTCCAISLWLRGLRMCTPLGREGEECHPGSHKVPFFRKRKHHTCPCLPNLLCSRFPDGRYRCSMDLKNINF
uniprot
proteins
function
FUNCTION: Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis. {ECO:0000269|PubMed:11259612, ECO:0000269|PubMed:11528470, ECO:0000269|PubMed:15292351, ECO:0000269|PubMed:17289879, ECO:0000269|PubMed:18339712}.
uniprot
proteins
mass_dalton
11715
uniprot
proteins
protein_family
AVIT (prokineticin) family
uniprot
proteins
pubmed
11259612
uniprot
proteins
pubmed
11528470
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15292351
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17289879
uniprot
proteins
pubmed
18339712
uniprot
proteins
sequence_length
105
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins