Entpd4
entrez
67464
canonical
uniprot
Q9DBT4
canonical
ensembl
ENSMUSG00000022066
resolver
ensembl
ENSMUSG00000095463
resolver
ensp
ENSMUSP00000138944
resolver
ensp
ENSMUSP00000354408
resolver
genesymbol
Entpd4
resolver
genesymbol_syn
Lalp70
resolver
genesymbol_syn
Lysal1
resolver
uniprot
Q8BSQ5
resolver
uniprot_entry
ENTP4_MOUSE
resolver
uniprot_entry
Q8BSQ5_MOUSE
resolver
amino_acid_sequence
MGRIGISCLFPASWHFSISPVGCPRILNTNLRQIVVISILAAAVSLLYFSVVIIRSKYGWLSKDKKFQRYLARVTDVEATDTNNPSVNYGIVVDCGSSGSRIFVYCWPRHNGNPHDLLDIRQMRDKNRKPVVMKIKPGISEFATSPEKVSDYISPLLSFAAEHVPRAKHKETPLYILCTAGMRVLPESQQKAILEDLLTDIPVHYDFLFSDSHAEVISGKQEGVYAWIGINFVLGRFEHIEEDDEAVVEVNIPGSESSEAIVRKRTAGVLDMGGVSTQIAYEVPQTVSFASSQQEEVAKNLLAEFNLGCDVHQTEHVYRVYVATFLGFGGNAARQRYEDRLFASTVQKNRLLGKQTGLTPDAPLLDPCLPLDIKDEIQQNGQTLYLQGTGDFDLCRETLQPFMNKTNETQTSLNGVYQPPIHFQNSEFYGFSEFYYCTEDVLRMGGDYNAARFTQAAKDYCATKWSILRERFDRGLYASHADLHRLKYQCFKSAWMFEVFHKGFSFPVTYKNLKTALQVYDKEVQWTLGAILYRTRFLPLRDIRQEVFRAGHAHWRGVSFVYNHYLFSGCFLVVLLSILLYLLRLRRIHRRAPRTGSLWMEEGLPSQKGPGPL
uniprot
proteins
ec_number
3.6.1.15
uniprot
proteins
ec_number
3.6.1.42
uniprot
proteins
ec_number
3.6.1.6
uniprot
proteins
function
FUNCTION: [Isoform 1]: Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner, with a preference for pyrimidines. Preferentially hydrolyzes UTP and TTP on UTP and TTP. AMP, ADP, ATP and UMP are not substrates. Preferentially activated by Ca(2+) over Mg(2+). {ECO:0000250|UniProtKB:Q9Y227}.; FUNCTION: [Isoform 2]: Has a broad substrate specificity with the ability of cleaving all nucleotide di- and triphosphates with the exception of adenosine di- and triphosphate (ADP and ATP). Preferentially hydrolyzes CTP, UDP, CDP, GTP and GDP. Can use either Ca(2+) or Mg(2+) equally. {ECO:0000250|UniProtKB:Q9Y227}.
uniprot
proteins
mass_dalton
69746
uniprot
proteins
protein_family
GDA1/CD39 NTPase family
uniprot
proteins
pubmed
10858452
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
613
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:Q9Y227}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9Y227}. Lysosome membrane {ECO:0000250|UniProtKB:Q9Y227}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9Y227}.; SUBCELLULAR LOCATION: [Isoform 2]: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9Y227}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..54; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 560..580; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins