Adss2
entrez
11566
canonical
uniprot
P46664
canonical
ensembl
ENSMUSG00000015961
resolver
ensp
ENSMUSP00000016105
resolver
ensp
ENSMUSP00000259369
resolver
ensp
ENSMUSP00000329776
resolver
enst
ENSMUST00000016105
resolver
genesymbol
Adss2
resolver
genesymbol_syn
ADSS
resolver
genesymbol_syn
ADSS2
resolver
genesymbol_syn
Adss
resolver
uniprot
B9EIE9
resolver
uniprot
Q9CQL9
resolver
uniprot_entry
B9EIE9_MOUSE
resolver
uniprot_entry
PURA2_MOUSE
resolver
uniprot_sec
Q9CQL9
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited competitively by AMP and IMP and non-competitively by fructose 1,6-bisphosphate. {ECO:0000269|PubMed:12482871}.
uniprot
proteins
amino_acid_sequence
MSISESSPAATSLPNGDCGRPRARSGGNRVTVVLGAQWGDEGKGKVVDLLAQDADIVCRCQGGNNAGHTVVVDSVEYDFHLLPSGIINPNVTAFIGNGVVIHLPGLFEEAEKNVQKGKGLDGWEKRLIISDRAHIVFDFHQAADGIQEQQRQEQAGKNLGTTKKGIGPVYSSKAARSGLRMCDLVSDFDGFSERFKVLANQYKSIYPTLEIDIEGELQQLKGYMERIKPMVKDGVYFLYEALHGPPKKILVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGMPPQNVGEVYGVVKAYTTRVGIGAFPTEQDNEIGELLQTRGREFGVTTGRKRRCGWLDLVSLKYAHMINGFTALALTKLDILDMFTEIKVGVAYKLDGETIPHFPANQEVLNKVEVQYKTLPGWNTDISNARTFKELPVNAQNYVRFIEDELQIPVKWIGVGKSRESMIQLF
uniprot
proteins
ec_number
6.3.4.4
uniprot
proteins
function
FUNCTION: Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. {ECO:0000269|PubMed:12482871}.
uniprot
proteins
mass_dalton
50021
uniprot
proteins
pathway_participation
PATHWAY: Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. {ECO:0000255|HAMAP-Rule:MF_03127}.
uniprot
proteins
protein_family
Adenylosuccinate synthetase family
uniprot
proteins
pubmed
12482871
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8308018
uniprot
proteins
sequence_length
456
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03127}. Mitochondrion {ECO:0000250|UniProtKB:A4Z6H1}.
uniprot
proteins