HCRTR2
entrez
3062
canonical
uniprot
O43614
canonical
ensembl
ENSG00000137252
resolver
ensp
ENSP00000359899
resolver
ensp
ENSP00000477548
resolver
enst
ENST00000370862
resolver
enst
ENST00000615358
resolver
genesymbol
HCRTR2
resolver
genesymbol_syn
ORXR2
resolver
genesymbol_syn
OX2R
resolver
genesymbol_syn
OXR2
resolver
hgnc
HGNC:4849
resolver
uniprot
Q5VTM0
resolver
uniprot
S4X0W3
resolver
uniprot_entry
OX2R_HUMAN
resolver
uniprot_entry
S4X0W3_HUMAN
resolver
uniprot_sec
Q5VTM0
resolver
amino_acid_sequence
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that binds neuropeptides orexin-A and orexin-B, two neuropeptides derived from a common precursor, prepro-orexin (PubMed:26950369, PubMed:33547286, PubMed:35614071, PubMed:9491897). Upon neuropeptide ligand binding, HCRTR2 can couple with both G(q)/11 and G(i)/o heterotrimeric G proteins thereby initiating distinct downstream signaling cascades (PubMed:35614071). Involved in regulating the sleep-wake cycle (By similarity). Contributes to central regulation of glucose homeostasis (By similarity). {ECO:0000250|UniProtKB:P58308, ECO:0000269|PubMed:26950369, ECO:0000269|PubMed:33547286, ECO:0000269|PubMed:35614071, ECO:0000269|PubMed:9491897}.
uniprot
proteins
mass_dalton
50694
uniprot
proteins
mutagenesis
MUTAGEN 33..49; /note="Missing: Abolishes response to orexin-A."; /evidence="ECO:0000269|PubMed:26950369"; MUTAGEN 44; /note="W->N: Abolishes response to orexin-A."; /evidence="ECO:0000269|PubMed:26950369"; MUTAGEN 111; /note="T->A: Reduces response to TAK-925. Abolishes response to orexin-B."; /evidence="ECO:0000269|PubMed:35614071"; MUTAGEN 111; /note="T->S: Reduces response to TAK-925."; /evidence="ECO:0000269|PubMed:35614071"; MUTAGEN 134; /note="Q->A: Abolishes response to TAK-925. Abolishes response to orexin-B."; /evidence="ECO:0000269|PubMed:35614071"; MUTAGEN 135; /note="T->A: Reduces response to TAK-925."; /evidence="ECO:0000269|PubMed:35614071"; MUTAGEN 324; /note="N->A: Strongly impairs response to orexin-A. Does not affect response to TAK-925. Abolishes response to orexin-B."; /evidence="ECO:0000269|PubMed:26950369, ECO:0000269|PubMed:35614071
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11723285
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
25533960
uniprot
proteins
pubmed
26950369
uniprot
proteins
pubmed
31860301
uniprot
proteins
pubmed
33547286
uniprot
proteins
pubmed
35614071
uniprot
proteins
pubmed
36417909
uniprot
proteins
pubmed
37264001
uniprot
proteins
pubmed
37264034
uniprot
proteins
pubmed
9491897
uniprot
proteins
sequence_length
444
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26950369, ECO:0000269|PubMed:9491897, ECO:0000305|PubMed:25533960}; Multi-pass membrane protein {ECO:0000269|PubMed:25533960}.
uniprot
proteins
transmembrane_region
TRANSMEM 55..75; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:25533960"; TRANSMEM 89..110; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:25533960"; TRANSMEM 128..150; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:25533960"; TRANSMEM 171..191; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:25533960"; TRANSMEM 223..243; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:25533960"; TRANSMEM 305..326; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:25533960"; TRANSMEM 343..366; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:25533960
uniprot
proteins