Kdm1a
entrez
500569
canonical
uniprot
A0A8I6G2K8
canonical
ensembl
ENSRNOG00000022372
resolver
ensembl
ENSRNOG00055025306
resolver
ensembl
ENSRNOG00060032136
resolver
ensembl
ENSRNOG00065022547
resolver
ensp
ENSRNOP00000052846
resolver
ensp
ENSRNOP00000078937
resolver
ensp
ENSRNOP00055035666
resolver
ensp
ENSRNOP00060046044
resolver
ensp
ENSRNOP00065031212
resolver
enst
ENSRNOT00055043676
resolver
enst
ENSRNOT00060055682
resolver
enst
ENSRNOT00065038503
resolver
genesymbol
Kdm1a
resolver
genesymbol_syn
Aof2
resolver
genesymbol_syn
Kiaa0601
resolver
genesymbol_syn
Lsd1
resolver
uniprot
A0A0G2K736
resolver
uniprot
B3STT9
resolver
uniprot
F1MA31
resolver
uniprot_entry
KDM1A_RAT
resolver
uniprot_sec
A0A0G2K736
resolver
uniprot_sec
B3STT9
resolver
uniprot_sec
F1MA31
resolver
activity_regulation
ACTIVITY REGULATION: The N-terminal sequences of INSM1 and SNAI1 compete with histone H3 for the same binding site and thereby inhibit histone demethylation (in vitro). {ECO:0000250|UniProtKB:O60341}.
uniprot
proteins
amino_acid_sequence
MLSGKKAAAAAAAAAAAAAGTEAGPGAAGGAENGSEVAAPPAGLAGPADIATGAAGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTAGPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPIKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
uniprot
proteins
ec_number
1.14.11.-
uniprot
proteins
ec_number
1.14.11.65
uniprot
proteins
ec_number
1.14.99.66
uniprot
proteins
function
FUNCTION: Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (AR)-dependent transcription, by being recruited to AR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in AR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation. Demethylates and stabilizes the DNA methylase DNMT1. Demethylates methylated 'Lys-42' and methylated 'Lys-117' of SOX2. Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Facilitates epithelial-to-mesenchymal transition by acting as an effector of SNAI1-mediated transcription repression of epithelial markers E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7. Required for the repression of GIPR expression. {ECO:0000250|UniProtKB:O60341}.; FUNCTION: [Isoform 2]: Neuron-specific histone demethylase that demethylates mono- and dimethylated 'Lys-20' of histone H4 (H4K20me1 and H4K20me2), a chromatin repressive mark (By similarity). This demethylation is crucial for the initiation and elongation of neuronal activity-regulated genes, required for spatial learning and memory (By similarity). Mediates H3K9me2 demethylation through cooperation with the supervillin protein (SVIL), and this H3K9 demethylase activity is essential for regulating gene expression during neuronal differentiation (By similarity). {ECO:0000250|UniProtKB:O60341, ECO:0000250|UniProtKB:Q6ZQ88}.; FUNCTION: [Isoform 4]: Neuron-specific histone demethylase that demethylates mono- and dimethylated 'Lys-20' of histone H4 (H4K20me1 and H4K20me2), a chromatin repressive mark (By similarity). This demethylation is crucial for the initiation and elongation of neuronal activity-regulated genes, required for spatial learning and memory (By similarity). Mediates H3K9me2 demethylation through cooperation with the supervillin protein (SVIL), and this H3K9 demethylase activity is essential for regulating gene expression during neuronal differentiation (By similarity). Plays a role in neuronal maturation (PubMed:20164337). {ECO:0000250|UniProtKB:O60341, ECO:0000250|UniProtKB:Q6ZQ88, ECO:0000269|PubMed:20164337}.
uniprot
proteins
mass_dalton
92711
uniprot
proteins
post_translational_modification
PTM: Acetylated by KAT8 in epithelial but not in mesenchymal cells, thereby regulating the epithelial-to-mesenchymal transition. Acetylation by KAT8 reduces KDM1A association with nucleosomes, thereby decreasing histone H3 demethylation, leading to transcription activation of target genes. {ECO:0000250|UniProtKB:O60341}.; PTM: Polyubiquitinated by JADE2; which leads to its proteasomal degradation. Deubiquitinated by USP38; preventing it from degradation by the 26S proteasome. {ECO:0000250|UniProtKB:O60341}.
uniprot
proteins
protein_family
Flavin monoamine oxidase family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
20164337
uniprot
proteins
pubmed
21124846
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
25954742
uniprot
proteins
sequence_length
852
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O60341}. Chromosome {ECO:0000250|UniProtKB:O60341}. Note=Associates with chromatin. {ECO:0000250|UniProtKB:O60341}.
uniprot
proteins