RUFY4
entrez
285180
canonical
uniprot
Q6ZNE9
canonical
ensembl
ENSG00000188282
resolver
ensp
ENSP00000363270
resolver
ensp
ENSP00000513250
resolver
genesymbol
RUFY4
resolver
hgnc
HGNC:24804
resolver
uniprot
Q6ZR96
resolver
uniprot_entry
RUFY4_HUMAN
resolver
uniprot_sec
Q6ZR96
resolver
amino_acid_sequence
MAEEGAILKVTKDLRAAVSAILQGYGDGQGPVTDTSAELHRLCGCLELLLQFDQKEQKSFLGPRKDYWDFLCTALRRQRGNMEPIHFVRSQDKLKTPLGKGRAFIRFCLARGQLAEALQLCLLNSELTREWYGPRSPLLCPERQEDILDSLYALNGVAFELDLQQPDLDGAWPMFSESRCSSSTQTQGRRPRKNKDAPKKIPAAYGGPENVQIEDSHTSQAICLQDAPSGQQLAGLPRSQQQRHLPFFLEKKGESSRKHRYPQSMWEPEGKELQLDQEERAPWIEIFLGNSTPSTQGQGKGAMGTQKEVIGMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGAVEGAVSGSRQGSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHLSSMAPECCVACSKIFGRFSRRYPCRLCGGLLCHACSMDYKKRDRCCPPCAQGREAQVT
uniprot
proteins
function
FUNCTION: ARL8 effector that promotes the coupling of endolysosomes to dynein-dynactin for retrograde transport along microtubules. Acts by binding both GTP-bound ARL8 and dynein-dynactin. In nonneuronal cells, promotes concentration of endolysosomes in the juxtanuclear area. In hippocampal neurons, drives retrograde transport of endolysosomes from the axon to the soma (PubMed:35314674). Positive regulator of macroautophagy in dendritic cells. Increases autophagic flux, probably by stimulating both autophagosome formation and facilitating tethering with lysosomes. Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through its FYVE-type zinc finger (PubMed:26416964). Positive regulator of osteoclast bone-resorbing activity, possibly by promoting late endosome-lysosome fusion by acting as an adapter protein between RAB7A on late endosomes and LAMP2 on primary lysosomes (By similarity). {ECO:0000250|UniProtKB:Q3TYX8, ECO:0000269|PubMed:26416964, ECO:0000269|PubMed:35314674}.
uniprot
proteins
mass_dalton
64350
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
26416964
uniprot
proteins
pubmed
35314674
uniprot
proteins
sequence_length
571
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:26416964}. Lysosome {ECO:0000269|PubMed:35314674}. Note=In the presence of ARL8, recruited to endolysosomes. {ECO:0000269|PubMed:35314674}.
uniprot
proteins