Glis2
entrez
83396
canonical
uniprot
Q8VDL9
canonical
ensembl
ENSMUSG00000014303
resolver
ensp
ENSMUSP00000014447
resolver
ensp
ENSMUSP00000241292
resolver
ensp
ENSMUSP00000331323
resolver
ensp
ENSMUSP00000331325
resolver
enst
ENSMUST00000014447
resolver
genesymbol
Glis2
resolver
genesymbol_syn
Gli5
resolver
genesymbol_syn
Nkl
resolver
uniprot
Q8R4X9
resolver
uniprot
Q99MY6
resolver
uniprot
Q99P73
resolver
uniprot_entry
GLIS2_MOUSE
resolver
uniprot_sec
Q8R4X9
resolver
uniprot_sec
Q99MY6
resolver
uniprot_sec
Q99P73
resolver
amino_acid_sequence
MHSLDEPLDLKLSITKLRAAREKRERTLGVVRHHALHRELGLVDDSPAPGSPGSPPPGFLLNPKFPEKVDGRFSAAPLVDLSLSPPSGLDSPNGSSSLSPECQGNGDLPPLPTAVDFQPLRYLDGVPSSFQFFLPLGSGGALHLPASSFLPPPKDKCLSPELPLAKQLVCRWAKCNQLFELLQDLVDHVNDHHVKPEQDARYCCHWEGCARHGRGFNARYKMLIHIRTHTNEKPHRCPTCNKSFSRLENLKIHNRSHTGEKPYVCPYEGCNKRYSNSSDRFKHTRTHYVDKPYYCKMPGCHKRYTDPSSLRKHIKAHGHFVSHEQQELLQLRPPPKPPLPTPDSGSYVSGAQIIIPNPAALFGGPSLPGLPLPLPPGPLDLSALACGNGGGGGGGIGPGLPGSVLPLNLAKNPLLPSPFGAGGLGLPVVSLLGGSAGSKAEGEKGRGSVPARVLGLEDHKTPLERTERSRSRPSPDGLPLLPGTVLDLSTGNSAASSPEVLTPGWVVIPPGSVLLKPAVVN
uniprot
proteins
function
FUNCTION: Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway. Represses the Hedgehog-dependent expression of Wnt4. Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition. Represses transcriptional activation by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation. {ECO:0000269|PubMed:11262234, ECO:0000269|PubMed:11741991, ECO:0000269|PubMed:16326862, ECO:0000269|PubMed:17289029, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:21816948}.
uniprot
proteins
mass_dalton
55842
uniprot
proteins
mutagenesis
MUTAGEN 170; /note="C->A: Impairs DNA-binding."; /evidence="ECO:0000269|PubMed:17344476"; MUTAGEN 175; /note="C->A: Abolishes interaction with CTNNB1. No effect on nuclear localization."; /evidence="ECO:0000269|PubMed:17289029"; MUTAGEN 288; /note="Y->A: No effect on C-terminus cleavage."; /evidence="ECO:0000269|PubMed:17344476"; MUTAGEN 290; /note="D->A: Impairs C-terminus cleavage."; /evidence="ECO:0000269|PubMed:17344476
uniprot
proteins
post_translational_modification
PTM: C-terminus cleavage is induced by interaction with CTNND1 and enhances by Src tyrosine kinase. {ECO:0000269|PubMed:16326862, ECO:0000269|PubMed:17344476}.
uniprot
proteins
protein_family
GLI C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
11262234
uniprot
proteins
pubmed
11741991
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16326862
uniprot
proteins
pubmed
17289029
uniprot
proteins
pubmed
17344476
uniprot
proteins
pubmed
21816948
uniprot
proteins
sequence_length
521
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle. Cytoplasm.
uniprot
proteins