Cr1l
entrez
54243
canonical
uniprot
Q63135
canonical
ensembl
ENSRNOG00000008193
resolver
ensembl
ENSRNOG00055011303
resolver
ensembl
ENSRNOG00060013940
resolver
ensembl
ENSRNOG00065004529
resolver
ensp
ENSRNOP00000010798
resolver
ensp
ENSRNOP00000074390
resolver
ensp
ENSRNOP00000097736
resolver
enst
ENSRNOT00000079549
resolver
genesymbol
Cr1l
resolver
genesymbol_syn
Cd46
resolver
genesymbol_syn
Crry
resolver
uniprot
A0A0G2K7Y0
resolver
uniprot
Q63612
resolver
uniprot_entry
A0A0G2K7Y0_RAT
resolver
uniprot_entry
CR1L_RAT
resolver
uniprot_sec
Q63612
resolver
amino_acid_sequence
MEASSPLDPVGRLVAFCRGGVHLAVLLLFLSPSTLGQCPAPPLFPYAKPINPTDESTFPVGTSLKYECRPGYIKRQFSITCEVNSVWTSPQDVCIRKQCETPLDPQNGIVHVNTDIRFGSSITYTCNEGYRLIGSSSAMCIISDQSVAWDAEAPICESIPCEIPPSIPNGDFFSPNREDFHYGMVVTYQCNTDARGKKLFNLVGEPSIHCTSIDGQVGVWSGPPPQCIELNKCTPPHVENAVIVSKNKSLFSLRDMVEFRCQDGFMMKGDSSVYCRSLNRWEPQLPSCFKVKSCGAFLGELPNGHVFVPQNLQLGAKVTFVCNTGYQLKGNSSSHCVLDGVESIWNSSVPVCEQVICKLPQDMSGFQKGLQMKKDYYYGDNVALECEDGYTLEGSSQSQCQSDASWDPPLPKCVSQVICKLPQDMSGFQKGLQMKKDYYYGDNVALECEDGYTLEGSSQSQCQSDASWDPPLPKCVSRSNSGLIAGIFIGIIVLILFIIFSYWMIMKFKKRNSTNEKCKEVGIYLNSKEDSCVQPQSLLTSQENNSTSSPARNSLTQEV
uniprot
proteins
function
FUNCTION: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. Also acts as a decay-accelerating factor, preventing the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade. Seems to act as a costimulatory factor for T-cells. May play a crucial role in early embryonic development by maintaining fetomaternal tolerance. {ECO:0000269|PubMed:15474557, ECO:0000269|PubMed:7534798, ECO:0000269|PubMed:8144902}.
uniprot
proteins
mass_dalton
61680
uniprot
proteins
protein_family
Receptors of complement activation (RCA) family
uniprot
proteins
pubmed
12767833
uniprot
proteins
pubmed
15474557
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21795784
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7534798
uniprot
proteins
pubmed
7590969
uniprot
proteins
pubmed
8117286
uniprot
proteins
pubmed
8144902
uniprot
proteins
sequence_length
559
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 483..503; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins