Nmbr
entrez
18101
canonical
uniprot
O54799
canonical
ensembl
ENSMUSG00000019865
resolver
ensp
ENSMUSP00000020015
resolver
enst
ENSMUST00000020015
resolver
genesymbol
Nmbr
resolver
uniprot
Q0VEH1
resolver
uniprot_entry
NMBR_MOUSE
resolver
uniprot_entry
Q0VEH1_MOUSE
resolver
amino_acid_sequence
MPPRSLSNLSFPTEANESELVPEVWEKDFLPDSDGTTAELVIRCVIPSLYLIIISVGLLGNIMLVKIFLTNSAMRNVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWVFGKLGCKLIPAIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGVLLWTSLKAVGIWVVSVLLAVPEAVFSEVARIGSLDNSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLVIISIYYYHIAKTLIKSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFVFCWFPNHVLYLYRSFNYKEIDPSLGHMIVTLVARVLSFSNSCVNPFALYLLSESFRKHFNSQLCCGRKSYPERSTSYLLSSSAVRMTSLKSNTKNVVTNSVLLNGHSTKQEIAL
uniprot
proteins
function
FUNCTION: Receptor for neuromedin-B (By similarity). Contributes to the maintenance of basal sigh rate through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (PubMed:26855425). Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (PubMed:34133943). These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (PubMed:34133943). Contributes to induction of acute itch, possibly through its activation on dorsal root ganglion neurons by the NMB peptide (PubMed:30734045). Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (PubMed:31601264). Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (PubMed:28780306). {ECO:0000250|UniProtKB:P24053, ECO:0000269|PubMed:26855425, ECO:0000269|PubMed:28780306, ECO:0000269|PubMed:30734045, ECO:0000269|PubMed:31601264, ECO:0000269|PubMed:34133943}.
uniprot
proteins
mass_dalton
43623
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26855425
uniprot
proteins
pubmed
28780306
uniprot
proteins
pubmed
30734045
uniprot
proteins
pubmed
31601264
uniprot
proteins
pubmed
34133943
uniprot
proteins
pubmed
9262170
uniprot
proteins
sequence_length
390
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 42..65; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 80..99; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 118..139; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 157..177; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 212..235; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 267..287; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 300..327; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins