SDC4
entrez
6385
canonical
uniprot
P31431
canonical
ensembl
ENSG00000124145
resolver
ensp
ENSP00000361818
resolver
genesymbol
SDC4
resolver
hgnc
HGNC:10661
resolver
uniprot
B4E1S6
resolver
uniprot
O00773
resolver
uniprot
Q16833
resolver
uniprot
Q53FN9
resolver
uniprot
Q6FGN3
resolver
uniprot_entry
B4E1S6_HUMAN
resolver
uniprot_entry
SDC4_HUMAN
resolver
uniprot_sec
O00773
resolver
uniprot_sec
Q16833
resolver
uniprot_sec
Q53FN9
resolver
uniprot_sec
Q6FGN3
resolver
amino_acid_sequence
MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPDDEDVVGPGQESDDFELSGSGDLDDLEDSMIGPEVVHPLVPLDNHIPERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSNKVSMSSTVQGSNIFERTEVLAALIVGGIVGILFAVFLILLLMYRMKKKDEGSYDLGKKPIYKKAPTNEFYA
uniprot
proteins
function
FUNCTION: Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). {ECO:0000269|PubMed:22660413}.
uniprot
proteins
mass_dalton
21642
uniprot
proteins
post_translational_modification
PTM: Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3. {ECO:0000269|PubMed:9169435}.; PTM: O-glycosylated; contains both chondroitin sulfate and heparan sulfate. Ser-39, Ser-61 and Ser-63 can all be modified by either chondroitin sulfate or heparan sulfate, and the protein exists in forms that contain only chondroitin sulfate, only heparan sulfate and both chondroitin sulfate and heparan sulfate. {ECO:0000250|UniProtKB:P34901}.
uniprot
proteins
protein_family
Syndecan proteoglycan family
uniprot
proteins
pubmed
11456484
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12842047
uniprot
proteins
pubmed
14675776
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
1500433
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16007225
uniprot
proteins
pubmed
16533050
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22660413
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
32337544
uniprot
proteins
pubmed
36213313
uniprot
proteins
pubmed
7916598
uniprot
proteins
pubmed
8797100
uniprot
proteins
pubmed
8889549
uniprot
proteins
pubmed
9169435
uniprot
proteins
sequence_length
198
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}. Secreted {ECO:0000269|PubMed:9169435}. Note=Shedding of the ectodomain produces a soluble form. {ECO:0000269|PubMed:9169435}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
uniprot
proteins
transmembrane_region
TRANSMEM 146..170; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins