Trim59
entrez
66949
canonical
uniprot
Q922Y2
canonical
ensembl
ENSMUSG00000034317
resolver
ensp
ENSMUSP00000103432
resolver
ensp
ENSMUSP00000120270
resolver
ensp
ENSMUSP00000177945
resolver
enst
ENSMUST00000107802
resolver
genesymbol
Trim59
resolver
genesymbol_syn
Mrf1
resolver
uniprot
E9QKA7
resolver
uniprot
Q9CSP2
resolver
uniprot
Q9CUD5
resolver
uniprot
Q9D740
resolver
uniprot_entry
TRI59_MOUSE
resolver
uniprot_sec
E9QKA7
resolver
uniprot_sec
Q9CSP2
resolver
uniprot_sec
Q9CUD5
resolver
uniprot_sec
Q9D740
resolver
amino_acid_sequence
MHNFEEELTCPICYSIFEDPRVLPCSHTFCRNCLENVLQASGNFYIWRPLRIPLKCPNCRSIIEIASTGIESLPVNFALRAIIEKYQQEDHPDVVTCPEHYRQPLNVYCLLDKKLVCGHCLTIGQHHGHPIDDLQSAYLKEKDTPQKLLKQLTDTHWTDITRLIEKLEEQKCHSEKIVQGDKEVVLQYFKELIDTLEQKKKYFLAALCDVGKMINQEYTPQIQGMKEIREQQLELMTITTSLQDESPLKFLEKIDEVRQRVQMLKQRPLPEVQPVEIYPRVSNVLKEEWSRIEIGRIKKAVIPEMRVSSKRTPCSWSDNDEKEMELFKILNIAIVSLISVILMLILLFNHHIITFLNEITSICFSEVFLSVYQSLSKNLYDLNNTVCYTLYLLKEFMWKIVSR
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase involved in different processes such as development and immune response (PubMed:22588174, PubMed:29467473). Serves as a negative regulator for innate immune signaling pathways by suppressing RLR-induced activation of IRF3/7 and NF-kappa-B via interaction with adapter ECSIT (PubMed:22588174). Regulates autophagy through modulating both the transcription and the ubiquitination of BECN1. On the one hand, regulates the transcription of BECN1 through negatively modulating the NF-kappa-B pathway. On the other hand, regulates TRAF6-mediated 'Lys-63'-linked ubiquitination of BECN1, thus affecting the formation of the BECN1-PIK3C3 complex. In addition, mediates 'Lys-48'-linked ubiquitination of TRAF6 and thereby promotes TRAF6 proteasomal degradation. Also acts as a critical regulator for early embryo development from blastocyst stage to gastrula through modulating F-actin assembly and WASH1 'Lys-63'-linked ubiquitination (PubMed:29467473). {ECO:0000250|UniProtKB:Q8IWR1, ECO:0000269|PubMed:22588174, ECO:0000269|PubMed:29467473}.
uniprot
proteins
mass_dalton
47238
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
12095697
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22588174
uniprot
proteins
pubmed
29467473
uniprot
proteins
sequence_length
403
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22588174}; Single-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 329..349; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins