Cenpq
entrez
83815
canonical
uniprot
Q9CPQ5
canonical
ensembl
ENSMUSG00000023919
resolver
ensp
ENSMUSP00000084353
resolver
ensp
ENSMUSP00000355529
resolver
enst
ENSMUST00000087114
resolver
genesymbol
Cenpq
resolver
uniprot
A0A1I7Q4A6
resolver
uniprot
Q8C2G4
resolver
uniprot
Q8VEF8
resolver
uniprot
Q9CX70
resolver
uniprot_entry
A0A1I7Q4A6_MOUSE
resolver
uniprot_entry
CENPQ_MOUSE
resolver
uniprot_sec
Q8C2G4
resolver
uniprot_sec
Q8VEF8
resolver
uniprot_sec
Q9CX70
resolver
amino_acid_sequence
MSGKARASRKKPQQVKRSLKQRANKEADLPENEVGNTAKRNRSHAKHLSSKVTGQATYVHLKRVKISSSKRTTWQPLPKDTEEYLQSMMESVILGILFNIKRKEEIQCHLNQLKKRLLQQCATLKVPPRKLNYLKDVSKMLKMEKAQERANEESLASLQEEIDKIVETTESMTESIQSLKNKIQILTSEVEEEEQEVKQVFHIDSNKVLALPELSQKSLKAPILQEEILALIPNQNALLKDLDVLHDSAPVKNVSAFIEEAYKKLDS
uniprot
proteins
function
FUNCTION: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores. {ECO:0000250|UniProtKB:Q7L2Z9}.
uniprot
proteins
mass_dalton
30501
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-49 is essential for CENPE recruitment to kinetochores and orderly chromosome congression. {ECO:0000250|UniProtKB:Q7L2Z9}.
uniprot
proteins
protein_family
CENP-Q/OKP1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
267
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7L2Z9}. Chromosome, centromere {ECO:0000250|UniProtKB:Q7L2Z9}. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex. {ECO:0000250|UniProtKB:Q7L2Z9}.
uniprot
proteins