Kcns2
entrez
66022
canonical
uniprot
Q9ER26
canonical
ensembl
ENSRNOG00000066111
resolver
ensembl
ENSRNOG00055027298
resolver
ensembl
ENSRNOG00060009983
resolver
ensembl
ENSRNOG00065015881
resolver
ensp
ENSRNOP00000088336
resolver
ensp
ENSRNOP00000101618
resolver
ensp
ENSRNOP00055038836
resolver
ensp
ENSRNOP00060013177
resolver
ensp
ENSRNOP00065020689
resolver
enst
ENSRNOT00000115427
resolver
enst
ENSRNOT00000122496
resolver
enst
ENSRNOT00055047239
resolver
enst
ENSRNOT00060016861
resolver
enst
ENSRNOT00065026381
resolver
genesymbol
Kcns2
resolver
uniprot_entry
KCNS2_RAT
resolver
amino_acid_sequence
MTRQSLWDLSETDVEDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDEQSDQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSVLSILVVLGSIITMCLNSLPDFQIPDSQGNPGEDPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESSPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKEENEGLATIPACWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYRRQKQLESAMRSCDFGDGMKEVPSVNLRDYYAHKVKSLMASLTNMSRSSPSELSLDDSLH
uniprot
proteins
function
FUNCTION: Potassium channel regulatory subunit that modulate the delayed rectifier voltage-gated potassium channel activity of KCNB1 and KCNB2 by altering their kinetics, expression levels, and shifting the half-inactivation potential to more polarized values. While it does not form functional channels on its own, it can form functional heterotetrameric channels with KCNB1 and KCNB2. Each regulatory subunit has unique regulatory properties that can lead to extensive inhibition, significant changes in kinetics, and/or substantial shifts in the voltage dependencies of the inactivation process. {ECO:0000250|UniProtKB:O35174}.
uniprot
proteins
mass_dalton
54317
uniprot
proteins
protein_family
Kv9.2/KCNS2 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
protein_family
S (TC 1.A.1.2) subfamily
uniprot
proteins
pubmed
11891605
uniprot
proteins
sequence_length
477
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O35174}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O35174}. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 or KCNB2. {ECO:0000250|UniProtKB:O35174}.
uniprot
proteins
transmembrane_region
TRANSMEM 185..206; /note="Helical; Name=Segment S1"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 226..248; /note="Helical; Name=Segment S2"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 260..280; /note="Helical; Name=Segment S3"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 291..311; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 327..348; /note="Helical; Name=Segment S5"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 389..417; /note="Helical; Name=Segment S6"; /evidence="ECO:0000250|UniProtKB:P63142
uniprot
proteins