Ss18l1
entrez
269397
canonical
uniprot
Q8BW22
canonical
ensembl
ENSMUSG00000039086
resolver
ensp
ENSMUSP00000041288
resolver
enst
ENSMUST00000041126
resolver
genesymbol
Ss18l1
resolver
genesymbol_syn
Crest
resolver
genesymbol_syn
Kiaa0693
resolver
uniprot
Q6A014
resolver
uniprot
Q7TQF3
resolver
uniprot
Q8BYQ7
resolver
uniprot_entry
CREST_MOUSE
resolver
uniprot_sec
Q6A014
resolver
uniprot_sec
Q7TQF3
resolver
uniprot_sec
Q8BYQ7
resolver
amino_acid_sequence
MSVAFASARPRGKGEVTQQTIQKMLDENHHLIQCILDYQSKGKTAECTQYQQILHRNLVYLATIADSNQNMQSLLPAPPTQNMNLGPGALSQSGSSQGLHPQGSLSDTVSTGLPPASLMQGQIGNGPNHVSMQQTAQSTLPTTSMSLSGSGHGTGPGYSHSGPTSQSVPMQGQGAISNYVSRTNINMQSNPVSMMHQQAATSHYNSAQGGSQHYQGQAPIAMMGQGGQGGSMMGQRPMAPYRPSQQGSSQQYLGQEEYYSEQYSHSQGSAEPMSQQYYPDGHGDYAYQQSSYTEQSYDRSFEDPTQHYYEGGNSQYSQQQAGYQQGTAQQQTYSQQQYPNQQSYPGQQQGYGPAQGAPSQYSSYQQGQGQQYGSYRTSQTGPSAQQQRPYGYEQGQYGNYQQ
uniprot
proteins
function
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP. {ECO:0000269|PubMed:14716005, ECO:0000269|PubMed:19081374}.
uniprot
proteins
mass_dalton
43729
uniprot
proteins
protein_family
SS18 family
uniprot
proteins
pubmed
14716005
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17920018
uniprot
proteins
pubmed
19081374
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
402
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Localizes to nuclear bodies. Colocalizes with SGO1 at kinetochore (By similarity). {ECO:0000250}.
uniprot
proteins