GCC2
entrez
9648
canonical
uniprot
Q8IWJ2
canonical
ensembl
ENSG00000135968
resolver
ensp
ENSP00000307939
resolver
ensp
ENSP00000386997
resolver
ensp
ENSP00000508981
resolver
ensp
ENSP00000718084
resolver
enst
ENST00000685519
resolver
genesymbol
GCC2
resolver
genesymbol_syn
KIAA0336
resolver
genesymbol_syn
RANBP2L4
resolver
hgnc
HGNC:23218
resolver
uniprot
A0A8I5QJB7
resolver
uniprot
A6H8X8
resolver
uniprot
B3KR21
resolver
uniprot
O15045
resolver
uniprot
Q4ZG46
resolver
uniprot
Q8TDH3
resolver
uniprot
Q9H2G8
resolver
uniprot_entry
A0A8I5QJB7_HUMAN
resolver
uniprot_entry
B3KR21_HUMAN
resolver
uniprot_entry
GCC2_HUMAN
resolver
uniprot_sec
A6H8X8
resolver
uniprot_sec
O15045
resolver
uniprot_sec
Q4ZG46
resolver
uniprot_sec
Q8TDH3
resolver
uniprot_sec
Q9H2G8
resolver
amino_acid_sequence
MEDLVQDGVASPATPGTGKSKLETLPKEDLIKFAKKQMMLIQKAKSRCTELEKEIEELRSKPVTEGTGDIIKALTERLDALLLEKAETEQQCLSLKKENIKMKQEVEDSVTKMGDAHKELEQSHINYVKEIENLKNELMAVRSKYSEDKANLQKQLEEAMNTQLELSEQLKFQNNSEDNVKKLQEEIEKIRPGFEEQILYLQKQLDATTDEKKETVTQLQNIIEANSQHYQKNINSLQEELLQLKAIHQEEVKELMCQIEASAKEHEAEINKLNELKENLVKQCEASEKNIQKKYECELENLRKATSNANQDNQICSILLQENTFVEQVVNEKVKHLEDTLKELESQHSILKDEVTYMNNLKLKLEMDAQHIKDEFFHEREDLEFKINELLLAKEEQGCVIEKLKSELAGLNKQFCYTVEQHNREVQSLKEQHQKEISELNETFLSDSEKEKLTLMFEIQGLKEQCENLQQEKQEAILNYESLREIMEILQTELGESAGKISQEFESMKQQQASDVHELQQKLRTAFTEKDALLETVNRLQGENEKLLSQQELVPELENTIKNLQEKNGVYLLSLSQRDTMLKELEGKINSLTEEKDDFINKLKNSHEEMDNFHKKCEREERLILELGKKVEQTIQYNSELEQKVNELTGGLEETLKEKDQNDQKLEKLMVQMKVLSEDKEVLSAEVKSLYEENNKLSSEKKQLSRDLEVFLSQKEDVILKEHITQLEKKLQLMVEEQDNLNKLLENEQVQKLFVKTQLYGFLKEMGSEVSEDSEEKDVVNVLQAVGESLAKINEEKCNLAFQRDEKVLELEKEIKCLQEESVVQCEELKSLLRDYEQEKVLLRKELEEIQSEKEALQSDLLEMKNANEKTRLENQNLLIQVEEVSQTCSKSEIHNEKEKCFIKEHENLKPLLEQKELRDRRAELILLKDSLAKSPSVKNDPLSSVKELEEKIENLEKECKEKEEKINKIKLVAVKAKKELDSSRKETQTVKEELESLRSEKDQLSASMRDLIQGAESYKNLLLEYEKQSEQLDVEKERANNFEHRIEDLTRQLRNSTLQCETINSDNEDLLARIETLQSNAKLLEVQILEVQRAKAMVDKELEAEKLQKEQKIKEHATTVNELEELQVQLQKQKKQLQKTMQELELVKKDAQQTTLMNMEIADYERLMKELNQKLTNKNNKIEDLEQEIKIQKQKQETLQEEITSLQSSVQQYEEKNTKIKQLLVKTKKELADSKQAETDHLILQASLKGELEASQQQVEVYKIQLAEITSEKHKIHEHLKTSAEQHQRTLSAYQQRVTALQEECRAAKAEQATVTSEFESYKVRVHNVLKQQKNKSMSQAETEGAKQEREHLEMLIDQLKIKLQDSQNNLQINVSELQTLQSEHDTLLERHNKMLQETVSKEAELREKLCSIQSENMMMKSEHTQTVSQLTSQNEVLRNSFRDQVRHLQEEHRKTVETLQQQLSKMEAQLFQLKNEPTTRSPVSSQQSLKNLRERRNTDLPLLDMHTVTREEGEGMETTDTESVSSASTYTQSLEQLLNSPETKLEPPLWHAEFTKEELVQKLSSTTKSADHLNGLLRETEATNAILMEQIKLLKSEIRRLERNQEREKSAANLEYLKNVLLQFIFLKPGSERERLLPVINTMLQLSPEEKGKLAAVAQGEEENASRSSGWASYLHSWSGLR
uniprot
proteins
function
FUNCTION: Golgin which probably tethers transport vesicles to the trans-Golgi network (TGN) and regulates vesicular transport between the endosomes and the Golgi. As a RAB9A effector it is involved in recycling of the mannose 6-phosphate receptor from the late endosomes to the TGN. May also play a role in transport between the recycling endosomes and the Golgi. Required for maintenance of the Golgi structure, it is involved in the biogenesis of noncentrosomal, Golgi-associated microtubules through recruitment of CLASP1 and CLASP2. {ECO:0000269|PubMed:16885419, ECO:0000269|PubMed:17488291, ECO:0000269|PubMed:17543864}.
uniprot
proteins
mass_dalton
195910
uniprot
proteins
mutagenesis
MUTAGEN 1588; /note="I->A: Slightly decreases RAB6A binding affinity. Decreases RAB9A binding affinity by 2-fold. Strongly decreases RAB6A or RAB9A binding affinity and abolishes Golgi localization; when associated with A-1595."; /evidence="ECO:0000269|PubMed:18243103"; MUTAGEN 1595; /note="L->A: Decreases RAB6A binding affinity by 2-fold. Strongly decreases RAB9A binding affinity. Strongly decreases RAB6A or RAB9A binding affinity and abolishes Golgi localization; when associated with A-1588."; /evidence="ECO:0000269|PubMed:18243103"; MUTAGEN 1618; /note="Y->A: No effect on interaction with RAB6A and RAB9A."; /evidence="ECO:0000269|PubMed:16885419, ECO:0000269|PubMed:18243103
uniprot
proteins
pubmed
10508479
uniprot
proteins
pubmed
11149944
uniprot
proteins
pubmed
12200376
uniprot
proteins
pubmed
12446665
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16885419
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17488291
uniprot
proteins
pubmed
17543864
uniprot
proteins
pubmed
18195106
uniprot
proteins
pubmed
18243103
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19703403
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
9205841
uniprot
proteins
sequence_length
1684
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein.
uniprot
proteins