Grk3
entrez
25372
canonical
uniprot
P26819
canonical
ensembl
ENSRNOG00000059456
resolver
ensp
ENSRNOP00000071696
resolver
enst
ENSRNOT00000082322
resolver
genesymbol
Grk3
resolver
genesymbol_syn
Adrbk2
resolver
uniprot
A0A0G2K145
resolver
uniprot_entry
A0A0G2K145_RAT
resolver
uniprot_entry
GRK3_RAT
resolver
amino_acid_sequence
MADLEAVLADVSYLMAMEKSKATPAARASKKVVLPEPSIRSVMQRYLAERNEITFDKIFNQKIGFLLFKDFCLNEIGEAVPQVKFYEEIKEYEKLDNEEDRLHRSRQMYDAYIMRELLSSTHQFSKQAVEHVQSHLSKKQVTPTLFQPYIEEICESLRGDIFQKFMESEKFTRFCQWKNVELNIHLSMNDFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRVKMKQGETLALNERIMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDMHYHLSQHGVFSEKEMRFYASEIILGLEHMHTCFVVYRDLKPANILLDEYGHVRISDLGLACDFSKKKPHASVGTHGYMAPEVLQKGTCYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVQLPDAFSPELRSLLEGLLQRDVSQRLGCYGGGARELKEHIFFKGIDWQYVYLRKYPPPLIPPRGEVNAADAFDIGSFDEEDTKGIKLLDCDQDLYKNFPLMISERWQQEVVETIYDAVNAETDKIEARKKAKNKQLCQEEDYAMGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNLLTMEQIMSVEETQIKDRKCILLRVKGGKQFVLQCESDPEFAQWLKELTCTFNEAQRLLRRAPKFLNKPRAAILEFSKPPLCHRNSSGL
uniprot
proteins
ec_number
2.7.11.15
uniprot
proteins
ec_number
2.7.11.16
uniprot
proteins
function
FUNCTION: Specifically phosphorylates the activated forms of G protein-coupled receptors (PubMed:1403099). Such receptor phosphorylation initiates beta-arrestin-mediated receptor internalization, and signaling events leading to their desensitization (PubMed:1403099). Phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors (PubMed:1403099). Also phosphorylates ligand-bound C3a and C5a anaphylatoxin receptors (C3AR1 and C5AR1, respectively), leading to receptor desensitization (By similarity). Positively regulates ciliary smoothened (SMO) signaling pathway by mediating phosphorylation of SMO, facilitating SMO trafficking into the cilium and the stimulation of SMO activity (By similarity). {ECO:0000250|UniProtKB:P35626, ECO:0000250|UniProtKB:Q3UYH7, ECO:0000269|PubMed:1403099}.
uniprot
proteins
mass_dalton
79887
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. {ECO:0000250|UniProtKB:P35626}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
GPRK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
1403099
uniprot
proteins
pubmed
9826657
uniprot
proteins
sequence_length
688
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynapse {ECO:0000269|PubMed:1403099}. Presynapse {ECO:0000269|PubMed:1403099}.
uniprot
proteins