Tle3
entrez
21887
canonical
uniprot
Q08122
canonical
ensembl
ENSMUSG00000032280
resolver
ensp
ENSMUSP00000034820
resolver
ensp
ENSMUSP00000123723
resolver
ensp
ENSMUSP00000124131
resolver
ensp
ENSMUSP00000124173
resolver
ensp
ENSMUSP00000124977
resolver
ensp
ENSMUSP00000125032
resolver
ensp
ENSMUSP00000294002
resolver
ensp
ENSMUSP00000294003
resolver
ensp
ENSMUSP00000294005
resolver
enst
ENSMUST00000034820
resolver
enst
ENSMUST00000159050
resolver
genesymbol
Tle3
resolver
genesymbol_syn
Esg
resolver
genesymbol_syn
mKIAA1547
resolver
uniprot
E0CXS9
resolver
uniprot
F8WIE2
resolver
uniprot
Q6PHP0
resolver
uniprot
Q80TC1
resolver
uniprot
Q923A4
resolver
uniprot_entry
E0CXS9_MOUSE
resolver
uniprot_entry
F8WIE2_MOUSE
resolver
uniprot_entry
Q80TC1_MOUSE
resolver
uniprot_entry
TLE3_MOUSE
resolver
uniprot_sec
Q6PHP0
resolver
uniprot_sec
Q923A4
resolver
amino_acid_sequence
MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLKVEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQQVAQAVERAKQVTMTELNAIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVTGSSSGLLALGALGSQAHLAVKDEKNHHELDHRERESSTNNSVSPSESLRASEKHRGSADYSMEAKKRKAEEKDSLSRYDSDGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKARGLKKDAPTSPASVASSSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTTPGLRSMPGKPPGMDPIGIMASALRTPITLTSSYPAPFAMMSHHEMNGSLTSPSAYAGLHNIPSQMSAAAAAAAAAYGRSPMVSFGAVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY
uniprot
proteins
function
FUNCTION: Transcriptional coregulator that binds to a number of transcription factors (PubMed:21459326). Acts as a regulator of adipogenesis both by acting as a corepressor of Wnt signaling and coactivator for PPARG (PubMed:21459326, PubMed:23473036). Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling (By similarity). Promotes diffentiation of white adipocytes by acting as a coactivator for PPARG and preventing the association between PRDM16 and PPARG, thereby preventing browning of white adipocytes (PubMed:23473036). {ECO:0000250|UniProtKB:Q04726, ECO:0000269|PubMed:21459326, ECO:0000269|PubMed:23473036}.
uniprot
proteins
mass_dalton
83447
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by XIAP/BIRC4. This ubiquitination does not affect its stability, nuclear localization, or capacity to tetramerize but inhibits its interaction with TCF7L2/TCF4. Ubiquitinated at Lys-720 by UBR5 in response to Wnt signaling, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome. {ECO:0000250|UniProtKB:Q04726}.
uniprot
proteins
protein_family
WD repeat Groucho/TLE family
uniprot
proteins
pubmed
11266540
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17584735
uniprot
proteins
pubmed
18254933
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21459326
uniprot
proteins
pubmed
23473036
uniprot
proteins
pubmed
23990468
uniprot
proteins
pubmed
8365415
uniprot
proteins
sequence_length
772
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23473036}. Chromosome {ECO:0000269|PubMed:23473036}. Note=Localizes to chromatin. {ECO:0000269|PubMed:23473036}.
uniprot
proteins