Mettl23
entrez
287918
canonical
uniprot
Q5RJL2
canonical
ensembl
ENSRNOG00055031599
resolver
ensembl
ENSRNOG00060023463
resolver
ensembl
ENSRNOG00065004910
resolver
ensp
ENSRNOP00055045218
resolver
ensp
ENSRNOP00060033581
resolver
ensp
ENSRNOP00065004957
resolver
enst
ENSRNOT00055054711
resolver
enst
ENSRNOT00060040631
resolver
enst
ENSRNOT00065007147
resolver
genesymbol
Mettl23
resolver
uniprot_entry
MET23_RAT
resolver
amino_acid_sequence
MAGARLFRFRDEPGPGADPTVLEVRVPQVLHVQYGMYVWPCAVVLAQYLWFHRRVLPGKAVLEIGAGVSLPGILAAKCGAKVTLSDSPELPHCLDICWQSCQMNNLPQVQIVGLTWGHISKDTLSLPPQDIILGSDVFFEPEDFESILATVYFLMQKNPKVQFWSTYQVRSADWSLEGLLYKWDMRCVHIPLESFDADKEDIAESTLPGRHTIEMLIISFAKDSS
uniprot
proteins
ec_number
2.1.1.319
uniprot
proteins
function
FUNCTION: Histone methyltransferase that dimethylates histone H3 at 'Arg-17', forming asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling. Maternal factor involved in epigenetic chromatin reprogramming of the paternal genome in the zygote: mediates H3R17me2a, promoting histone H3.3 incorporation in the male pronucleus, leading to TET3 recruitment and subsequent DNA demethylation. {ECO:0000250|UniProtKB:A2AA28}.
uniprot
proteins
mass_dalton
25277
uniprot
proteins
protein_family
METTL23 family
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
225
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:A2AA28}. Cytoplasm {ECO:0000250|UniProtKB:A2AA28}. Note=Localizes in male and female zygote pronucleus and cytoplasm. {ECO:0000250|UniProtKB:A2AA28}.
uniprot
proteins