Hsd11b1
entrez
25116
canonical
uniprot
P16232
canonical
genesymbol
Hsd11b1
resolver
genesymbol_syn
Hsd11
resolver
uniprot
O09170
resolver
uniprot
Q6LDH6
resolver
uniprot_entry
DHI1_RAT
resolver
uniprot_sec
O09170
resolver
uniprot_sec
Q6LDH6
resolver
amino_acid_sequence
MKKYLLPVLVLCLGYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMAFAERFVVEAGKLLGGLDMLILNHITQTTMSLFHDDIHSVRRSMEVNFLSYVVLSTAALPMLKQSNGSIAIISSMAGKMTQPLIASYSASKFALDGFFSTIRKEHLMTKVNVSITLCVLGFIDTETALKETSGIILSQAAPKEECALEIIKGTVLRKDEVYYDKSSWTPLLLGNPGRRIMEFLSLRSYNRDLFVSN
uniprot
proteins
ec_number
1.1.1.146
uniprot
proteins
ec_number
1.1.1.201
uniprot
proteins
function
FUNCTION: Controls the reversible conversion of biologically active glucocorticoids such as 11-dehydrocorticosterone to corticosterone using NADP(H) (PubMed:12460758, PubMed:14973125, PubMed:8613810). Participates in the corticosteroid receptor-mediated anti-inflammatory response, as well as metabolic and homeostatic processes (By similarity). Bidirectional in vitro, predominantly functions as a reductase in vivo, thereby increasing the concentration of active glucocorticoids (PubMed:12460758). It has broad substrate specificity, besides glucocorticoids, it accepts other steroid and sterol substrates (PubMed:14973125). Interconverts 7-oxo- and 7-hydroxy-neurosteroids such as 7-oxopregnenolone and 7beta-hydroxypregnenolone, 7-oxodehydroepiandrosterone (3beta-hydroxy-5-androstene-7,17-dione) and 7beta-hydroxydehydroepiandrosterone (3beta,7beta-dihydroxyandrost-5-en-17-one), among others (By similarity). Catalyzes the stereo-specific conversion of the major dietary oxysterol, 7-ketocholesterol (7-oxocholesterol), into the more polar 7-beta-hydroxycholesterol metabolite (PubMed:14973125). 7-oxocholesterol is one of the most important oxysterols, it participates in several events such as induction of apoptosis, accumulation in atherosclerotic lesions, lipid peroxidation, and induction of foam cell formation (By similarity). Mediates the 7-oxo reduction of 7-oxolithocholate mainly to chenodeoxycholate, and to a lesser extent to ursodeoxycholate, both in its free form and when conjugated to glycine or taurine, providing a link between glucocorticoid activation and bile acid metabolism (By similarity). Catalyzes the synthesis of 7-beta-25-dihydroxycholesterol from 7-oxo-25-hydroxycholesterol in vitro, which acts as a ligand for the G protein-coupled receptor (GPCR) Epstein-Barr virus-induced gene 2 (EBI2) and may thereby regulate immune cell migration (By similarity). {ECO:0000250|UniProtKB:P28845, ECO:0000250|UniProtKB:P50172, ECO:0000269|PubMed:12460758, ECO:0000269|PubMed:14973125, ECO:0000269|PubMed:8613810, ECO:0000303|PubMed:12460758}.
uniprot
proteins
mass_dalton
31883
uniprot
proteins
mutagenesis
MUTAGEN 110; /note="D->N: Slight loss of activity."; MUTAGEN 179; /note="Y->F,S: Complete loss of activity."; /evidence="ECO:0000269|PubMed:1417845"; MUTAGEN 183; /note="K->R: Complete loss of activity."; /evidence="ECO:0000269|PubMed:1417845
uniprot
proteins
post_translational_modification
PTM: Glycosylated.
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
10906322
uniprot
proteins
pubmed
12460758
uniprot
proteins
pubmed
1417845
uniprot
proteins
pubmed
14973125
uniprot
proteins
pubmed
1508221
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1733955
uniprot
proteins
pubmed
21453287
uniprot
proteins
pubmed
2387261
uniprot
proteins
pubmed
2808402
uniprot
proteins
pubmed
3460996
uniprot
proteins
pubmed
8613810
uniprot
proteins
sequence_length
288
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type II membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 5..20; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins