Slc19a1
entrez
20509
canonical
uniprot
P41438
canonical
ensembl
ENSMUSG00000001436
resolver
ensp
ENSMUSP00000101050
resolver
ensp
ENSMUSP00000116784
resolver
ensp
ENSMUSP00000317769
resolver
ensp
ENSMUSP00000317780
resolver
ensp
ENSMUSP00000317784
resolver
ensp
ENSMUSP00000317789
resolver
ensp
ENSMUSP00000317799
resolver
genesymbol
Slc19a1
resolver
uniprot
Q542F3
resolver
uniprot
Q62450
resolver
uniprot
Q62451
resolver
uniprot_entry
Q542F3_MOUSE
resolver
uniprot_entry
S19A1_MOUSE
resolver
uniprot_sec
Q62450
resolver
uniprot_sec
Q62451
resolver
amino_acid_sequence
MVPTGQVAEKQAYEEPRQDHELKSWRCLVFYLCFFGFMAQLRPGESFITPFLLERKFTKEQVTNEIIPMLPYSHLAVLVPVFLLTDYLRYKPVLVLQCLSFVCVWLLLLLGTSVVHMQLMEVFYSVTMAARIAYSSYIFSLVHPSRYQRMASYSRAAVLLGVFISSVLGQALVTVGHISTYTLNCVSLGFILFSLVLSLFLKRPKRSLFFNRSTLARGALPCELDQMHPGPDRPETRKLDRMLGTCRDSFLVRMLSELVENARQPQLRLWCLWWVFNSSGYYLITYYVHVLWRSTDSSLSYNGAVDAASTLLSAITSFSAGFLSIRWTLWSKLVIAGVIAIQASLVFCMFQIRDIWVCYVTFVLFRGAYQFLVPIATFQIASSLSKELCALVFGINTFLATALKTCITLVVSDKRGLGLQVRDQFRIYFIYFLMLSITCFAWAGLDGLRYCQRGRHQPLAQAQELRSPLETSVQAISLQDGDLRGPQPSAPQLLSEDGMEDDRGDLRVEAKA
uniprot
proteins
function
FUNCTION: Antiporter that mediates the import of reduced folates, driven by the export of organic anions (PubMed:8276792, PubMed:8664315, PubMed:9111015, PubMed:9748272). Also acts as an importer of immunoreactive cyclic dinucleotides, but with a lower transporter activity (PubMed:31511694, PubMed:36265513). Mechanistically, acts as a secondary active transporter, which exports intracellular organic anions down their concentration gradients to facilitate the uptake of its substrates (By similarity). Has high affinity for N5-methyltetrahydrofolate, the predominant circulating form of folate (PubMed:8276792, PubMed:9111015). Also mediates the import of antifolate drug methotrexate (PubMed:8276792, PubMed:8664315, PubMed:9748272). 5-amino-4-imidazolecarboxamide riboside (AICAR), when phosphorylated to AICAR monophosphate, can serve as an organic anion for antiporter activity (By similarity). {ECO:0000250|UniProtKB:P41440, ECO:0000269|PubMed:31511694, ECO:0000269|PubMed:36265513, ECO:0000269|PubMed:8276792, ECO:0000269|PubMed:8664315, ECO:0000269|PubMed:9111015, ECO:0000269|PubMed:9748272}.
uniprot
proteins
mass_dalton
58150
uniprot
proteins
mutagenesis
MUTAGEN 48; /note="I->F: Induces resistance to 5,10-dideazatetrahydrofolate; when associated with G-105."; /evidence="ECO:0000269|PubMed:9748272"; MUTAGEN 105; /note="W->G: Induces resistance to 5,10-dideazatetrahydrofolate; when associated with F-48."; /evidence="ECO:0000269|PubMed:9748272
uniprot
proteins
protein_family
Reduced folate carrier (RFC) transporter (TC 2.A.48) family
uniprot
proteins
pubmed
10787414
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31511694
uniprot
proteins
pubmed
36265513
uniprot
proteins
pubmed
7559435
uniprot
proteins
pubmed
8276792
uniprot
proteins
pubmed
8664315
uniprot
proteins
pubmed
9111015
uniprot
proteins
pubmed
9161403
uniprot
proteins
pubmed
9748272
uniprot
proteins
sequence_length
512
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10787414}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P41440}. Apical cell membrane {ECO:0000269|PubMed:10787414}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P41440}. Basolateral cell membrane {ECO:0000250|UniProtKB:P41440}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P41440}.
uniprot
proteins
transmembrane_region
TRANSMEM 30..50; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P41440"; TRANSMEM 63..85; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P41440"; TRANSMEM 90..110; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P41440"; TRANSMEM 115..137; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P41440"; TRANSMEM 152..176; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P41440"; TRANSMEM 182..200; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P41440"; TRANSMEM 267..292; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P41440"; TRANSMEM 301..323; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P41440"; TRANSMEM 330..350; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:P41440"; TRANSMEM 354..377; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:P41440"; TRANSMEM 392..415; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:P41440"; TRANSMEM 424..448; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:P41440
uniprot
proteins