GREM1
entrez
26585
canonical
uniprot
O60565
canonical
ensembl
ENSG00000166923
resolver
ensembl
ENSG00000276886
resolver
ensembl
ENSG00000282046
resolver
ensp
ENSP00000453141
resolver
ensp
ENSP00000498748
resolver
ensp
ENSP00000498763
resolver
genesymbol
GREM1
resolver
genesymbol_syn
CKTSF1B1
resolver
genesymbol_syn
DAND2
resolver
genesymbol_syn
DRM
resolver
hgnc
HGNC:2001
resolver
uniprot
A6XAA7
resolver
uniprot
B3KTR9
resolver
uniprot
Q52LV3
resolver
uniprot
Q8N914
resolver
uniprot
Q8N936
resolver
uniprot_entry
A6XAA7_HUMAN
resolver
uniprot_entry
B3KTR9_HUMAN
resolver
uniprot_entry
GREM1_HUMAN
resolver
uniprot_sec
Q52LV3
resolver
uniprot_sec
Q8N914
resolver
uniprot_sec
Q8N936
resolver
amino_acid_sequence
MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD
uniprot
proteins
disease_involvement
DISEASE: Polyposis syndrome, mixed hereditary 1 (HMPS1) [MIM:601228]: A disease characterized by apparent autosomal dominant inheritance of multiple types of colorectal polyp, with colorectal carcinoma occurring in a high proportion of affected individuals. Patients can develop polyps of multiple and mixed morphologies, including serrated lesions, Peutz-Jeghers polyps, juvenile polyps, conventional adenomas and colorectal carcinoma in the absence of any identifiable extra-colonic features. {ECO:0000269|PubMed:22561515}. Note=The disease is caused by variants affecting the gene represented in this entry. HMPS1 is caused by a duplication spanning the 3' end of the SCG5 gene and a region upstream of the GREM1 locus. This duplication is associated with increased allele-specific GREM1 expression that may cause reduced bone morphogenetic protein (BMP) pathway activity. This mechanism also underlies tumorigenesis in juvenile polyposis of the large bowel (PubMed:22561515). {ECO:0000269|PubMed:22561515}.
uniprot
proteins
function
FUNCTION: Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (PubMed:27036124). Acts as inhibitor of monocyte chemotaxis. Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed (By similarity). {ECO:0000250|UniProtKB:O35793, ECO:0000250|UniProtKB:O70326, ECO:0000269|PubMed:27036124}.
uniprot
proteins
mass_dalton
20697
uniprot
proteins
protein_family
DAN family
uniprot
proteins
pubmed
10744662
uniprot
proteins
pubmed
10894942
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22561515
uniprot
proteins
pubmed
27036124
uniprot
proteins
pubmed
9660951
uniprot
proteins
sequence_length
184
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
uniprot
proteins