Chst10
entrez
140568
canonical
uniprot
O54702
canonical
ensembl
ENSRNOG00000012815
resolver
ensembl
ENSRNOG00055018911
resolver
ensembl
ENSRNOG00060019560
resolver
ensembl
ENSRNOG00065028564
resolver
ensp
ENSRNOP00000017714
resolver
ensp
ENSRNOP00000073358
resolver
ensp
ENSRNOP00055026103
resolver
ensp
ENSRNOP00060027690
resolver
ensp
ENSRNOP00065040386
resolver
enst
ENSRNOT00000017714
resolver
enst
ENSRNOT00000087866
resolver
enst
ENSRNOT00055032249
resolver
enst
ENSRNOT00060033802
resolver
enst
ENSRNOT00065049250
resolver
genesymbol
Chst10
resolver
uniprot
A0A0G2K5A9
resolver
uniprot
A0A8L2Q8P2
resolver
uniprot_entry
A0A0G2K5A9_RAT
resolver
uniprot_entry
CHSTA_RAT
resolver
uniprot_sec
A0A8L2Q8P2
resolver
amino_acid_sequence
MHHQWLLLAACFWVIFMFMVASKFITLTFKDPDGYSAKQEFVFLTAMPEAEKLRGEKHFSEVMKPTGKMLSESHPDQPPVYLERLELIRNACKEEALRNLSHTEVSKFVLDRIFVCDKHKILFCQTPKVGNTQWKKVLIVLNGAFSSIEEIPENVVHDHEKNGLPRLSSFSKIGIQKRLKTYFKFFIVRDPFERLISAFKDKFVHNPRFEPWYRHEIAPGIIRKYRKNRTETRGIQFEDFVRYLGDPNRRWLDLQFGDHIIHWVTYVKLCAPCEIKYSVIGHHETLEADAPYILKEAGIDHLVSYPTIPPGITMYNRTKVEQYFLGISKRDIRRLYARFEGDFKLFGYQKPDFLLN
uniprot
proteins
ec_number
2.8.2.-
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of sulfate from 3'-phosphoadenylyl sulfate (PAPS) to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure 3-O-sulfo-beta-D-GlcA-(1->3)-beta-D-Gal-(1->4)-D-GlcNAc-R, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis (PubMed:9368071). Sulfates terminal glucuronyl residue of the laminin globular (LG)-domain binding epitope on DAG1/alpha-dystroglycan and prevents further polymerization by LARGE1 glycosyltransferase. Likely defines the chain length of LG epitope, conferring binding specificity to extracellular matrix components (PubMed:23723439). Plays a role in down-regulating the steroid hormones. Sulfates glucuronidated estrogens and androgens with an impact in hormone cycle and fertility. Has a preference for glucuronyl moiety at the 3-hydroxyl group of a sterol ring rather than the 17-hydroxyl group, showing high catalytic efficiency for 17beta-estradiol 3-O-(beta-D-glucuronate) and dehydroepiandrosterone 3-O-(beta-D-glucuronate) hormones (By similarity). {ECO:0000250|UniProtKB:O43529, ECO:0000269|PubMed:23723439, ECO:0000269|PubMed:9368071}.
uniprot
proteins
mass_dalton
42027
uniprot
proteins
pathway_participation
PATHWAY: Steroid metabolism. {ECO:0000250|UniProtKB:O43529}.; PATHWAY: Protein modification; carbohydrate sulfation. {ECO:0000250|UniProtKB:O43529}.
uniprot
proteins
protein_family
Sulfotransferase 2 family
uniprot
proteins
pubmed
11044619
uniprot
proteins
pubmed
23723439
uniprot
proteins
pubmed
9368071
uniprot
proteins
sequence_length
356
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:23723439}; Single-pass type II membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..27; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins