SLC30A3
entrez
7781
canonical
uniprot
Q99726
canonical
ensembl
ENSG00000115194
resolver
ensp
ENSP00000233535
resolver
ensp
ENSP00000388219
resolver
enst
ENST00000233535
resolver
genesymbol
SLC30A3
resolver
genesymbol_syn
ZNT3
resolver
hgnc
HGNC:11014
resolver
uniprot
B4DXX8
resolver
uniprot
Q8TC03
resolver
uniprot_entry
B4DXX8_HUMAN
resolver
uniprot_entry
ZNT3_HUMAN
resolver
uniprot_sec
Q8TC03
resolver
amino_acid_sequence
MEPSPAAGGLETTRLVSPRDRGGAGGSLRLKSLFTEPSEPLPEESKPVEMPFHHCHRDPLPPPGLTPERLHARRQLYAACAVCFVFMAGEVVGGYLAHSLAIMTDAAHLLADVGSMMGSLFSLWLSTRPATRTMTFGWHRSETLGALASVVSLWMVTGILLYLAFVRLLHSDYHIEGGAMLLTASIAVCANLLMAFVLHQAGPPHSHGSRGAEYAPLEEGPEEPLPLGNTSVRAAFVHVLGDLLQSFGVLAASILIYFKPQYKAADPISTFLFSICALGSTAPTLRDVLRILMEGTPRNVGFEPVRDTLLSVPGVRATHELHLWALTLTYHVASAHLAIDSTADPEAVLAEASSRLYSRFGFSSCTLQVEQYQPEMAQCLRCQEPPQA
uniprot
proteins
function
FUNCTION: Probable proton-coupled zinc ion antiporter mediating the import of zinc from cytoplasm into synaptic vesicles and participating to cellular zinc ion homeostasis in the brain. {ECO:0000269|PubMed:17349999, ECO:0000269|PubMed:19521526, ECO:0000269|PubMed:26647834}.
uniprot
proteins
mass_dalton
41945
uniprot
proteins
mutagenesis
MUTAGEN 330; /note="Y->F: No effect on homodimerization."; /evidence="ECO:0000269|PubMed:19521526"; MUTAGEN 357; /note="Y->F: Increased homodimerization. Increased localization to intracellular vesicles."; /evidence="ECO:0000269|PubMed:19521526"; MUTAGEN 372; /note="Y->F: Decreased homodimerization. Decreased localization to intracellular vesicles. Loss of zinc transporter activity."; /evidence="ECO:0000269|PubMed:19521526
uniprot
proteins
post_translational_modification
PTM: Homodimerization through dityrosine bonds is stimulated by oxidative stress. {ECO:0000269|PubMed:19521526}.
uniprot
proteins
protein_family
Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
uniprot
proteins
protein_family
SLC30A subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17349999
uniprot
proteins
pubmed
19521526
uniprot
proteins
pubmed
26647834
uniprot
proteins
pubmed
36204728
uniprot
proteins
pubmed
8962159
uniprot
proteins
sequence_length
388
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000305|PubMed:26647834}; Multi-pass membrane protein {ECO:0000255}. Synapse, synaptosome {ECO:0000250|UniProtKB:P97441}. Late endosome membrane {ECO:0000269|PubMed:17349999}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:17349999}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 76..96; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 106..126; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 146..166; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 178..198; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 236..256; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 265..285; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins