Tlr1
entrez
21897
canonical
uniprot
Q9EPQ1
canonical
ensembl
ENSMUSG00000044827
resolver
ensp
ENSMUSP00000060793
resolver
ensp
ENSMUSP00000142500
resolver
ensp
ENSMUSP00000322328
resolver
ensp
ENSMUSP00000322329
resolver
enst
ENSMUST00000059349
resolver
enst
ENSMUST00000197315
resolver
genesymbol
Tlr1
resolver
uniprot
B9EJ46
resolver
uniprot
Q9EPW5
resolver
uniprot_entry
B9EJ46_MOUSE
resolver
uniprot_entry
TLR1_MOUSE
resolver
uniprot_sec
Q9EPW5
resolver
amino_acid_sequence
MTKPNSLIFYCIIVLGLTLMKIQLSEECELIIKRPNANLTRVPKDLPLQTTTLDLSQNNISELQTSDILSLSKLRVLIMSYNRLQYLNISVFKFNTELEYLDLSHNELKVILCHPTVSLKHLDLSFNAFDALPICKEFGNMSQLQFLGLSGSRVQSSSVQLIAHLNISKVLLVLGDAYGEKEDPESLRHVSTETLHIVFPSKREFRFLLDVSVSTTIGLELSNIKCVLEDQGCSYFLRALSKLGKNLKLSNLTLNNVETTWNSFINILQIVWHTPVKYFSISNVKLQGQLAFRMFNYSDTSLKALSIHQVVTDVFSFPQSYIYSIFANMNIQNFTMSGTHMVHMLCPSQVSPFLHVDFTDNLLTDMVFKDCRNLVRLKTLSLQKNQLKNLENIILTSAKMTSLQKLDISQNSLRYSDGGIPCAWTQSLLVLNLSSNMLTGSVFRCLPPKVKVLDLHNNRIMSIPKDVTHLQALQELNVASNSLTDLPGCGAFSSLSVLVIDHNSVSHPSEDFFQSCQNIRSLTAGNNPFQCTCELRDFVKNIGWVAREVVEGWPDSYRCDYPESSRGTALRDFHMSPLSCDTVLLTVTIGATMLVLAVTGAFLCLYFDLPWYVRMLCQWTQTRHRARHIPLEELQRNLQFHAFVSYSGHDSAWVKNELLPNLEKDDIQICLHERNFVPGKSIVENIINFIEKSYKSIFVLSPHFIQSEWCHYELYFAHHNLFHEGSDNLILILLAPIPQYSIPTNYHKLKTLMSRRTYLEWPTEKNKHGLFWANLRASINVKLVNQAEGTCYTQQ
uniprot
proteins
function
FUNCTION: Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Acts as a coreceptor for M.tuberculosis lipoproteins LprG, LpqH and PhoS1 (pstS1), in conjunction with TLR2 and for some but not all lipoproteins CD14 and/or CD36. The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). {ECO:0000250|UniProtKB:Q15399, ECO:0000269|PubMed:19362712}.
uniprot
proteins
mass_dalton
90673
uniprot
proteins
protein_family
Toll-like receptor family
uniprot
proteins
pubmed
11095740
uniprot
proteins
pubmed
11123271
uniprot
proteins
pubmed
17998391
uniprot
proteins
pubmed
19362712
uniprot
proteins
pubmed
38378891
uniprot
proteins
sequence_length
795
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11095740, ECO:0000269|PubMed:17998391}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:11095740}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000250|UniProtKB:Q15399}. Golgi apparatus {ECO:0000250|UniProtKB:Q15399}. Note=Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to triacylated lipoproteins, TLR2:TLR1 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus. {ECO:0000250|UniProtKB:Q15399}.
uniprot
proteins
transmembrane_region
TRANSMEM 583..603; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins