TMEM178A
entrez
130733
canonical
uniprot
Q8NBL3
canonical
ensembl
ENSG00000152154
resolver
ensp
ENSP00000281961
resolver
ensp
ENSP00000567400
resolver
ensp
ENSP00000567401
resolver
ensp
ENSP00000793736
resolver
genesymbol
TMEM178A
resolver
genesymbol_syn
TMEM178
resolver
hgnc
HGNC:28517
resolver
uniprot
Q6UWI6
resolver
uniprot
Q8N6N4
resolver
uniprot_entry
T178A_HUMAN
resolver
uniprot_sec
Q6UWI6
resolver
uniprot_sec
Q8N6N4
resolver
amino_acid_sequence
MEPRALVTALSLGLSLCSLGLLVTAIFTDHWYETDPRRHKESCERSRAGADPPDQKNRLMPLSHLPLRDSPPLGRRLLPGGPGRADPESWRSLLGLGGLDAECGRPLFATYSGLWRKCYFLGIDRDIDTLILKGIAQRCTAIKYHFSQPIRLRNIPFNLTKTIQQDEWHLLHLRRITAGFLGMAVAVLLCGCIVATVSFFWEESLTQHVAGLLFLMTGIFCTISLCTYAASISYDLNRLPKLIYSLPADVEHGYSWSIFCAWCSLGFIVAAGGLCIAYPFISRTKIAQLKSGRDSTV
uniprot
proteins
function
FUNCTION: Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1. {ECO:0000250|UniProtKB:Q9CZ16}.
uniprot
proteins
mass_dalton
33019
uniprot
proteins
protein_family
TMEM178 family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16303743
uniprot
proteins
sequence_length
297
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9CZ16}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 180..200; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 209..229; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 258..278; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins