STRADA
entrez
92335
canonical
uniprot
Q7RTN6
canonical
ensembl
ENSG00000266173
resolver
ensp
ENSP00000245865
resolver
ensp
ENSP00000336655
resolver
ensp
ENSP00000365000
resolver
ensp
ENSP00000376677
resolver
ensp
ENSP00000398841
resolver
ensp
ENSP00000462922
resolver
ensp
ENSP00000463872
resolver
ensp
ENSP00000464547
resolver
ensp
ENSP00000481505
resolver
ensp
ENSP00000491528
resolver
ensp
ENSP00000491580
resolver
ensp
ENSP00000491922
resolver
ensp
ENSP00000492238
resolver
ensp
ENSP00000492578
resolver
ensp
ENSP00000492877
resolver
ensp
ENSP00000529021
resolver
ensp
ENSP00000529024
resolver
enst
ENST00000245865
resolver
enst
ENST00000578008
resolver
enst
ENST00000578801
resolver
enst
ENST00000617949
resolver
enst
ENST00000638276
resolver
enst
ENST00000638309
resolver
enst
ENST00000638708
resolver
enst
ENST00000638888
resolver
enst
ENST00000640086
resolver
enst
ENST00000858962
resolver
enst
ENST00000858965
resolver
genesymbol
STRADA
resolver
genesymbol_syn
LYK5
resolver
genesymbol_syn
STRAD
resolver
hgnc
HGNC:30172
resolver
uniprot
A0A1W2PPG2
resolver
uniprot
A0A1W2PPJ9
resolver
uniprot
A0A1W2PQE8
resolver
uniprot
A0A1W2PR00
resolver
uniprot
A0A1W2PS04
resolver
uniprot
A0ACM8PXG4
resolver
uniprot
B4DDE3
resolver
uniprot
B4DW17
resolver
uniprot
H3BLS8
resolver
uniprot
J3KTC9
resolver
uniprot
J3QQS3
resolver
uniprot
J3QS66
resolver
uniprot
Q5JPI2
resolver
uniprot
Q7Z4K9
resolver
uniprot
Q86YC8
resolver
uniprot
Q8NC31
resolver
uniprot
Q8NCF1
resolver
uniprot
Q9H272
resolver
uniprot_entry
A0A1W2PPG2_HUMAN
resolver
uniprot_entry
A0A1W2PPJ9_HUMAN
resolver
uniprot_entry
A0A1W2PQE8_HUMAN
resolver
uniprot_entry
A0A1W2PR00_HUMAN
resolver
uniprot_entry
A0A1W2PS04_HUMAN
resolver
uniprot_entry
A0ACM8PXG4_HUMAN
resolver
uniprot_entry
J3QQS3_HUMAN
resolver
uniprot_entry
J3QS66_HUMAN
resolver
uniprot_entry
Q86YC8_HUMAN
resolver
uniprot_entry
STRAA_HUMAN
resolver
uniprot_sec
B4DDE3
resolver
uniprot_sec
B4DW17
resolver
uniprot_sec
H3BLS8
resolver
uniprot_sec
J3KTC9
resolver
uniprot_sec
Q5JPI2
resolver
uniprot_sec
Q7Z4K9
resolver
uniprot_sec
Q8NC31
resolver
uniprot_sec
Q8NCF1
resolver
uniprot_sec
Q9H272
resolver
amino_acid_sequence
MSFLVSKPERIRRWVSEKFIVEGLRDLELFGEQPPGDTRRKTNDASSESIASFSKQEVMSSFLPEGGCYELLTVIGKGFEDLMTVNLARYKPTGEYVTVRRINLEACSNEMVTFLQGELHVSKLFNHPNIVPYRATFIADNELWVVTSFMAYGSAKDLICTHFMDGMNELAIAYILQGVLKALDYIHHMGYVHRSVKASHILISVDGKVYLSGLRSNLSMISHGQRQRVVHDFPKYSVKVLPWLSPEVLQQNLQGYDAKSDIYSVGITACELANGHVPFKDMPATQMLLEKLNGTVPCLLDTSTIPAEELTMSPSRSVANSGLSDSLTTSTPRPSNGDSPSHPYHRTFSPHFHHFVEQCLQRNPDARPSASTLLNHSFFKQIKRRASEALPELLRPVTPITNFEGSQSQDHSGIFGLVTNLEELEVDDWEF
uniprot
proteins
disease_involvement
DISEASE: Note=A homozygous 7-kb deletion involving STRADA is a cause of a syndrome characterized by polyhydramnios, megalencephaly and symptomatic epilepsy.
uniprot
proteins
function
FUNCTION: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation. {ECO:0000269|PubMed:12805220, ECO:0000269|PubMed:14517248, ECO:0000269|PubMed:19892943}.
uniprot
proteins
mass_dalton
48369
uniprot
proteins
mutagenesis
MUTAGEN 185; /note="Y->F: Suppresses STK11/LKB1 activation without affecting complex assembly."; /evidence="ECO:0000269|PubMed:19892943"; MUTAGEN 231; /note="H->A: Inhibits interaction with STK11/LKB1; when associated with A-."; /evidence="ECO:0000269|PubMed:19892943"; MUTAGEN 233; /note="F->A: Inhibits interaction with STK11/LKB1; when associated with A-."; /evidence="ECO:0000269|PubMed:19892943"; MUTAGEN 241; /note="L->A: Inhibits interaction with STK11/LKB1."; /evidence="ECO:0000269|PubMed:19892943"; MUTAGEN 251; /note="Q->A: Inhibits interaction with STK11/LKB1."; /evidence="ECO:0000269|PubMed:19892943"; MUTAGEN 329; /note="T->A: Loss of STK11/LKB1-mediated phosphorylation."; /evidence="ECO:0000269|PubMed:12805220"; MUTAGEN 419; /note="T->A: Loss of STK11/LKB1-mediated phosphorylation."; /evidence="ECO:0000269|PubMed:12805220
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
protein_family
STE20 subfamily
uniprot
proteins
pubmed
12747765
uniprot
proteins
pubmed
12805220
uniprot
proteins
pubmed
14517248
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14730349
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17522105
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19892943
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
431
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12805220, ECO:0000269|PubMed:14517248}. Cytoplasm {ECO:0000269|PubMed:12805220, ECO:0000269|PubMed:14517248}.
uniprot
proteins