Kynu
entrez
116682
canonical
uniprot
P70712
canonical
ensembl
ENSRNOG00000029993
resolver
ensp
ENSRNOP00000105352
resolver
genesymbol
Kynu
resolver
uniprot
Q68G25
resolver
uniprot
Q7M0D0
resolver
uniprot
Q9QW90
resolver
uniprot_entry
KYNU_RAT
resolver
uniprot_sec
Q68G25
resolver
uniprot_sec
Q7M0D0
resolver
uniprot_sec
Q9QW90
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by o-methylbenzoylalanine (OMBA). {ECO:0000269|PubMed:9180257}.
uniprot
proteins
amino_acid_sequence
MEPSPLELPVDAVRRIATELNCDPTDERVALRLDEEDKLKRFKDCFYIPKMRDLPSIDLSLVNEDDNAIYFLGNSLGLQPKMVKTYLEEELDKWAKIGAYGHEVGKRPWIIGDESIVSLMKDIVGAHEKEIALMNALTVNLHLLLLSFFKPTPKRHKILLEAKAFPSDHYAIESQIQLHGLDVEKSMRMIKPREGEETLRMEDILEVIEKEGDSIAVVLFSGLHFYTGQLFNIPAITQAGHAKGCFVGFDLAHAVGNVELHLHDWDVDFACWCSYKYLNSGAGGLAGAFIHEKHAHTIKPALVGWFGHELSTRFNMDNKLQLIPGVNGFRISNPPILLVCSLHASLEIFQQATMTALRRKSILLTGYLEYLLKHYHGGNDTENKRPVVNIITPSRAEERGCQLTLTFSISKKGVFKELEKRGVVCDKREPEGIRVAPVPLYNSFHDVYKFIRLLTAILDSTERN
uniprot
proteins
ec_number
3.7.1.3
uniprot
proteins
function
FUNCTION: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. {ECO:0000255|HAMAP-Rule:MF_03017, ECO:0000269|PubMed:9180257}.
uniprot
proteins
mass_dalton
52470
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid degradation; L-kynurenine degradation; L-alanine and anthranilate from L-kynurenine: step 1/1. {ECO:0000255|HAMAP-Rule:MF_03017}.; PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 2/3. {ECO:0000255|HAMAP-Rule:MF_03017}.
uniprot
proteins
protein_family
Kynureninase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7578221
uniprot
proteins
pubmed
8706755
uniprot
proteins
pubmed
9180257
uniprot
proteins
sequence_length
464
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000255|HAMAP-Rule:MF_03017}.
uniprot
proteins