ACSL1
entrez
2180
canonical
uniprot
P33121
canonical
ensembl
ENSG00000151726
resolver
ensp
ENSP00000281455
resolver
ensp
ENSP00000422607
resolver
ensp
ENSP00000425006
resolver
ensp
ENSP00000426150
resolver
ensp
ENSP00000426244
resolver
ensp
ENSP00000516351
resolver
ensp
ENSP00000516352
resolver
ensp
ENSP00000516353
resolver
ensp
ENSP00000534750
resolver
ensp
ENSP00000534759
resolver
ensp
ENSP00000534762
resolver
ensp
ENSP00000534766
resolver
ensp
ENSP00000534767
resolver
ensp
ENSP00000534769
resolver
ensp
ENSP00000534771
resolver
ensp
ENSP00000534775
resolver
ensp
ENSP00000534778
resolver
ensp
ENSP00000534779
resolver
ensp
ENSP00000534782
resolver
ensp
ENSP00000534790
resolver
ensp
ENSP00000534797
resolver
enst
ENST00000507295
resolver
enst
ENST00000864700
resolver
enst
ENST00000864710
resolver
enst
ENST00000864720
resolver
enst
ENST00000864738
resolver
genesymbol
ACSL1
resolver
genesymbol_syn
FACL1
resolver
genesymbol_syn
FACL2
resolver
genesymbol_syn
LACS
resolver
genesymbol_syn
LACS1
resolver
genesymbol_syn
LACS2
resolver
hgnc
HGNC:3569
resolver
uniprot
A8K9T3
resolver
uniprot
B4E0R0
resolver
uniprot
B7Z452
resolver
uniprot
D3DP57
resolver
uniprot
E7EPM6
resolver
uniprot
E7EQJ5
resolver
uniprot
P41215
resolver
uniprot
Q8N8V7
resolver
uniprot
Q8TA99
resolver
uniprot_entry
A8K9T3_HUMAN
resolver
uniprot_entry
ACSL1_HUMAN
resolver
uniprot_entry
B4E0R0_HUMAN
resolver
uniprot_entry
E7EPM6_HUMAN
resolver
uniprot_sec
B7Z452
resolver
uniprot_sec
D3DP57
resolver
uniprot_sec
E7EQJ5
resolver
uniprot_sec
P41215
resolver
uniprot_sec
Q8N8V7
resolver
uniprot_sec
Q8TA99
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited at high temperature and by arachidonate. {ECO:0000250|UniProtKB:P18163}.
uniprot
proteins
amino_acid_sequence
MQAHELFRYFRMPELVDFRQYVRTLPTNTLMGFGAFAALTTFWYATRPKPLKPPCDLSMQSVEVAGSGGARRSALLDSDEPLVYFYDDVTTLYEGFQRGIQVSNNGPCLGSRKPDQPYEWLSYKQVAELSECIGSALIQKGFKTAPDQFIGIFAQNRPEWVIIEQGCFAYSMVIVPLYDTLGNEAITYIVNKAELSLVFVDKPEKAKLLLEGVENKLIPGLKIIVVMDAYGSELVERGQRCGVEVTSMKAMEDLGRANRRKPKPPAPEDLAVICFTSGTTGNPKGAMVTHRNIVSDCSAFVKATENTVNPCPDDTLISFLPLAHMFERVVECVMLCHGAKIGFFQGDIRLLMDDLKVLQPTVFPVVPRLLNRMFDRIFGQANTTLKRWLLDFASKRKEAELRSGIIRNNSLWDRLIFHKVQSSLGGRVRLMVTGAAPVSATVLTFLRAALGCQFYEGYGQTECTAGCCLTMPGDWTAGHVGAPMPCNLIKLVDVEEMNYMAAEGEGEVCVKGPNVFQGYLKDPAKTAEALDKDGWLHTGDIGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYMRSEPVAQVFVHGESLQAFLIAIVVPDVETLCSWAQKRGFEGSFEELCRNKDVKKAILEDMVRLGKDSGLKPFEQVKGITLHPELFSIDNGLLTPTMKAKRPELRNYFRSQIDDLYSTIKV
uniprot
proteins
ec_number
6.2.1.15
uniprot
proteins
ec_number
6.2.1.24
uniprot
proteins
ec_number
6.2.1.3
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:21242590, PubMed:22633490, PubMed:24269233). Preferentially uses palmitoleate, oleate and linoleate (PubMed:24269233). Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs) (By similarity). {ECO:0000250|UniProtKB:P18163, ECO:0000269|PubMed:21242590, ECO:0000269|PubMed:22633490, ECO:0000269|PubMed:24269233}.
uniprot
proteins
mass_dalton
77943
uniprot
proteins
protein_family
ATP-dependent AMP-binding enzyme family
uniprot
proteins
pubmed
10548543
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
1607358
uniprot
proteins
pubmed
21242590
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22633490
uniprot
proteins
pubmed
24269233
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
8584017
uniprot
proteins
sequence_length
698
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24269233}; Single-pass type III membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..45; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins