ITPKB
entrez
3707
canonical
uniprot
P27987
canonical
ensembl
ENSG00000143772
resolver
ensp
ENSP00000355748
resolver
ensp
ENSP00000411152
resolver
ensp
ENSP00000782079
resolver
genesymbol
ITPKB
resolver
hgnc
HGNC:6179
resolver
uniprot
B2R9J0
resolver
uniprot
Q5VWL9
resolver
uniprot
Q5VWM0
resolver
uniprot
Q96BZ2
resolver
uniprot
Q96JS1
resolver
uniprot
Q9UH47
resolver
uniprot_entry
B2R9J0_HUMAN
resolver
uniprot_entry
IP3KB_HUMAN
resolver
uniprot_sec
Q5VWL9
resolver
uniprot_sec
Q5VWM0
resolver
uniprot_sec
Q96BZ2
resolver
uniprot_sec
Q96JS1
resolver
uniprot_sec
Q9UH47
resolver
activity_regulation
ACTIVITY REGULATION: IP3K is activated by calcium and calmodulin. Form B is much more sensitive to calcium/calmodulin than form A. {ECO:0000269|PubMed:11846419, ECO:0000269|PubMed:12747803}.
uniprot
proteins
amino_acid_sequence
MAVYCYALNSLVIMNSANEMKSGGGPGPSGSETPPPPRRAVLSPGSVFSPGRGASFLFPPAESLSPEEPRSPGGWRSGRRRLNSSSGSGSGSSGSSVSSPSWAGRLRGDRQQVVAAGTLSPPGPEEAKRKLRILQRELQNVQVNQKVGMFEAHIQAQSSAIQAPRSPRLGRARSPSPCPFRSSSQPPGRVLVQGARSEERRTKSWGEQCPETSGTDSGRKGGPSLCSSQVKKGMPPLPGRAAPTGSEAQGPSAFVRMEKGIPASPRCGSPTAMEIDKRGSPTPGTRSCLAPSLGLFGASLTMATEVAARVTSTGPHRPQDLALTEPSGRARELEDLQPPEALVERQGQFLGSETSPAPERGGPRDGEPPGKMGKGYLPCGMPGSGEPEVGKRPEETTVSVQSAESSDSLSWSRLPRALASVGPEEARSGAPVGGGRWQLSDRVEGGSPTLGLLGGSPSAQPGTGNVEAGIPSGRMLEPLPCWDAAKDLKEPQCPPGDRVGVQPGNSRVWQGTMEKAGLAWTRGTGVQSEGTWESQRQDSDALPSPELLPQDPDKPFLRKACSPSNIPAVIITDMGTQEDGALEETQGSPRGNLPLRKLSSSSASSTGFSSSYEDSEEDISSDPERTLDPNSAFLHTLDQQKPRVSKSWRKIKNMVHWSPFVMSFKKKYPWIQLAGHAGSFKAAANGRILKKHCESEQRCLDRLMVDVLRPFVPAYHGDVVKDGERYNQMDDLLADFDSPCVMDCKMGIRTYLEEELTKARKKPSLRKDMYQKMIEVDPEAPTEEEKAQRAVTKPRYMQWRETISSTATLGFRIEGIKKEDGTVNRDFKKTKTREQVTEAFREFTKGNHNILIAYRDRLKAIRTTLEVSPFFKCHEVIGSSLLFIHDKKEQAKVWMIDFGKTTPLPEGQTLQHDVPWQEGNREDGYLSGLNNLVDILTEMSQDAPLA
uniprot
proteins
ec_number
2.7.1.127
uniprot
proteins
function
FUNCTION: Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis. {ECO:0000269|PubMed:11846419, ECO:0000269|PubMed:12747803, ECO:0000269|PubMed:1654894}.
uniprot
proteins
mass_dalton
102376
uniprot
proteins
mutagenesis
MUTAGEN 897; /note="D->N: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:12747803
uniprot
proteins
protein_family
Inositol phosphokinase (IPK) family
uniprot
proteins
pubmed
11846419
uniprot
proteins
pubmed
12747803
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1654894
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
23060452
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
946
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12747803}. Cytoplasm {ECO:0000269|PubMed:12747803}. Endoplasmic reticulum {ECO:0000269|PubMed:12747803}.
uniprot
proteins