Emd
entrez
13726
canonical
uniprot
O08579
canonical
ensembl
ENSMUSG00000001964
resolver
ensp
ENSMUSP00000002029
resolver
ensp
ENSMUSP00000094133
resolver
ensp
ENSMUSP00000094158
resolver
ensp
ENSMUSP00000346163
resolver
ensp
ENSMUSP00000346168
resolver
enst
ENSMUST00000002029
resolver
enst
ENSMUST00000088313
resolver
enst
ENSMUST00000096424
resolver
genesymbol
Emd
resolver
genesymbol_syn
Sta
resolver
uniprot
F6Y5D1
resolver
uniprot
I7HJS1
resolver
uniprot
Q3THM8
resolver
uniprot
Q3TIH6
resolver
uniprot
Q3UJP3
resolver
uniprot_entry
EMD_MOUSE
resolver
uniprot_entry
F6Y5D1_MOUSE
resolver
uniprot_entry
I7HJS1_MOUSE
resolver
uniprot_entry
Q3THM8_MOUSE
resolver
uniprot_sec
Q3TIH6
resolver
uniprot_sec
Q3UJP3
resolver
amino_acid_sequence
MDDYAVLSDTELAAVLRQYNIPHGPIVGSTRKLYEKKIFEYETQRRRLLPPNSSSSSFSYQFSDLDSAAVDSDMYDLPKKEDALLYQSKDYNDDYYEESYLTTKTYGEPESVGMSKSFRQPGTSLVDADTFHHQVRDDIFSSLEEEGKDRERLIYGQDSAYQSIAHYRPISNVSRSSLGLSYYPTSSTSSVSSSSSSPSSWLTRRAIRPEKQAPAAALGQDRQVPLWGQLLLFLVFAAFLLFVYYSIQAEEGNPFWMDP
uniprot
proteins
function
FUNCTION: Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C. Together with NEMP1, contributes to nuclear envelope stiffness in germ cells. {ECO:0000250|UniProtKB:P50402}.
uniprot
proteins
mass_dalton
29436
uniprot
proteins
pubmed
10579712
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18230648
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19933576
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32923640
uniprot
proteins
pubmed
9107678
uniprot
proteins
sequence_length
259
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000250|UniProtKB:P50402}; Single-pass membrane protein; Nucleoplasmic side {ECO:0000250|UniProtKB:P50402}. Nucleus outer membrane. Note=Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non-farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus (By similarity). {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 224..244; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins