Cyp4b1
entrez
13120
canonical
uniprot
Q64462
canonical
ensembl
ENSMUSG00000028713
resolver
ensp
ENSMUSP00000099768
resolver
enst
ENSMUST00000102707
resolver
genesymbol
Cyp4b1
resolver
uniprot
Q3TNA0
resolver
uniprot_entry
CP4B1_MOUSE
resolver
uniprot_entry
Q3TNA0_MOUSE
resolver
amino_acid_sequence
MALSFLSPSLSRLGLWASVVILMVTVLKLLSLLFRRQKLARALDSFPGPPKHWLFGHALEIQKTGGLDKVVTWTEQFPYAHPLWLGQFIVFLNIYEPDYAKAVYSRGDPKAAYVYDFFLQWIGKGLLVLEGPKWFQHRKLLTPGFHYDVLKPYVAIFAESTRVMLDKWEKKASENKSFDIFCDVGHMALDTLMKCTFGKGDSGLSHSDNSYYLAVSDLTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACQIAHDHTDHVIRQRKAALQDEKEQKKLQERRHLDFLDILLGARDESGIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPMHQQRCREEVREILGDRDSFQWDDLAQMTYLTMCMKECFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISLHIYALHRNSAVWPDPEVFDPLRFSPENMTGRHPFAFMPFSAGPRNCIGQQFAMNEMKVVTALCLLRFEFSPDPSKIPIKVPQLILRSKNGIHLYLKPLGPGSGK
uniprot
proteins
ec_number
1.14.14.1
uniprot
proteins
function
FUNCTION: Catalyzes the omega- and (omega-1)-hydroxylation of saturated fatty acids and n-alkanes (PubMed:7639529). Also bioactivates xenobiotics such as the procarcinogen 3-methoxy-4-aminoazobenzene and the cyclic arylamines 2-aminofluorene and 2-aminoanthracene (PubMed:7639529). In addition, catalyzes O-dealkylation of 7-ethoxycoumarin (By similarity). Functions at the interface of xenobiotic and endobiotic metabolism, contributing both to fatty acid and hydrocarbon oxidation and to the bioactivation of diverse xenobiotics (PubMed:7639529). Preferentially hydroxylates the terminal carbon (omega-hydroxylation) of medium-chain fatty acids (C8-C10), with regioselectivity decreasing as chain length increases. C8 fatty acids and C7 n-alkanes display optimal chain length for regioselective omega-hydroxylation, and n-alkanes (C7-C10) are generally turned over faster and with higher regioselectivity than the corresponding fatty acids. In addition to omega/omega-1 hydroxylation, also catalyzes alpha-, beta-, gamma- and delta-hydroxylation of mid-chain length fatty acids, whereas fatty alcohols of the same chain length are almost exclusively hydroxylated at the omega, omega-1 and omega-2 positions (By similarity). {ECO:0000250|UniProtKB:P15128, ECO:0000250|UniProtKB:P15129, ECO:0000269|PubMed:7639529}.
uniprot
proteins
mass_dalton
58900
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7639529
uniprot
proteins
sequence_length
511
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P15128}; Peripheral membrane protein {ECO:0000250|UniProtKB:P15128}. Microsome membrane {ECO:0000269|PubMed:7639529}; Peripheral membrane protein {ECO:0000250|UniProtKB:P15128}.
uniprot
proteins