HSH2D
entrez
84941
canonical
uniprot
Q96JZ2
canonical
ensembl
ENSG00000196684
resolver
ensp
ENSP00000482604
resolver
ensp
ENSP00000483354
resolver
ensp
ENSP00000670173
resolver
ensp
ENSP00000670174
resolver
genesymbol
HSH2D
resolver
genesymbol_syn
ALX
resolver
hgnc
HGNC:24920
resolver
uniprot
B5ME72
resolver
uniprot
Q6ZNG7
resolver
uniprot_entry
HSH2D_HUMAN
resolver
uniprot_sec
B5ME72
resolver
uniprot_sec
Q6ZNG7
resolver
amino_acid_sequence
MTEAGKLPLPLPPRLDWFVHTQMGQLAQDGVPEWFHGAISREDAENLLESQPLGSFLIRVSHSHVGYTLSYKAQSSCCHFMVKLLDDGTFMIPGEKVAHTSLDALVTFHQQKPIEPRRELLTQPCRQKDPANVDYEDLFLYSNAVAEEAACPVSAPEEASPKPVLCHQSKERKPSAEMNRITTKEATSSCPPKSPLGETRQKLWRSLKMLPERGQRVRQQLKSHLATVNLSSLLDVRRSTVISGPGTGKGSQDHSGDPTSGDRGYTDPCVATSLKSPSQPQAPKDRKVPTRKAERSVSCIEVTPGDRSWHQMVVRALSSQESKPEHQGLAEPENDQLPEEYQQPPPFAPGYC
uniprot
proteins
function
FUNCTION: May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter. {ECO:0000250, ECO:0000269|PubMed:11700021, ECO:0000269|PubMed:12960172, ECO:0000269|PubMed:15284240}.
uniprot
proteins
mass_dalton
39002
uniprot
proteins
mutagenesis
MUTAGEN 10..13; /note="PLPP->ALPA: No change in the ability to inhibit RE/AP up-regulation in response to TCR/CD28 stimulation."; /evidence="ECO:0000269|PubMed:15284240"; MUTAGEN 59; /note="R->K: Loss of the ability to inhibit RE/AP up-regulation in response to TCR/CD28 stimulation."; MUTAGEN 116; /note="P->A: No change in the ability to inhibit RE/AP up-regulation in response to TCR/CD28 stimulation."; /evidence="ECO:0000269|PubMed:15284240"; MUTAGEN 135; /note="Y->F: No change in the ability to inhibit RE/AP up-regulation in response to TCR/CD28 stimulation."; /evidence="ECO:0000269|PubMed:15284240"; MUTAGEN 192..195; /note="PKSP->AKSA: No change in the ability to inhibit RE/AP up-regulation in response to TCR/CD28 stimulation."; /evidence="ECO:0000269|PubMed:15284240"; MUTAGEN 341; /note="Y->F: No change in the ability to inhibit RE/AP up-regulation in response to TCR/CD28 stimulation."; /evidence="ECO:0000269|PubMed:15284240"; MUTAGEN 346..349; /note="PFAP->AFAA: No change in the ability to inhibit RE/AP up-regulation in response to TCR/CD28 stimulation."; /evidence="ECO:0000269|PubMed:15284240
uniprot
proteins
post_translational_modification
PTM: May be phosphorylated by FES and ACK1. {ECO:0000269|PubMed:11700021, ECO:0000269|PubMed:15284240}.
uniprot
proteins
pubmed
11700021
uniprot
proteins
pubmed
12960172
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15284240
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16169852
uniprot
proteins
sequence_length
352
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
uniprot
proteins