Cacna1a
entrez
25398
canonical
uniprot
P54282
canonical
ensembl
ENSRNOG00000052707
resolver
ensp
ENSRNOP00000070304
resolver
ensp
ENSRNOP00000080121
resolver
ensp
ENSRNOP00000096924
resolver
genesymbol
Cacna1a
resolver
genesymbol_syn
BCCA1
resolver
genesymbol_syn
Cach4
resolver
genesymbol_syn
Cacn3
resolver
genesymbol_syn
Cacnl1a4
resolver
uniprot
O70368
resolver
uniprot
Q01541
resolver
uniprot_entry
CAC1A_RAT
resolver
uniprot_entry
O70368_RAT
resolver
uniprot_sec
Q01541
resolver
amino_acid_sequence
MARFGDEMPGRYGAGGGGSGPAAGVVVGAAGGRGAGGSRQGGQPGAQRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIVALGFAFHKGSYLRNGWNVMDFVVVLTGILATVGTEFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDVEQRHPFDGALRRATLKKSKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLWLAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDEIKSQGGVQGGMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREALYGDAAERWPTTYARPLRPDVKTHLDRPLVVDPQENRNNNTNKSRAPEALRQTARPRESARDPDARRAWPSSPERAPGREGPYGRESEPQQREHAPPREHVPWDADPERAKAGDAPRRHTHRPVAEGEPRRHRARRRPGDEPDDRPERRPRPRDATRPARAADGEGDDGERKRRHRHGPPAHDDRERRHRRRKESQGSGVPMSGPNLSTTRPIQQDLGRQDLPLAEDLDNMKNNKLATGEPASPHDSLGHSGLPPSPAKIGNSTNPGPALATNPQNAASRRTPNNPGNPSNPGPPKTPENSLIVTNPSSTQPNSAKTARKPEHMAVEIPPACPPLNHTVVQVNKNANPDPLPKKEEEKKEEEEADPGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFERDCRGKYLLYEKNEVKARDREWKKYDFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDGEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGIQKPECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTDLTVGKIYAAMMIMEYYRQSKAKKLQAMREEQNRTPLMFQRMEPPSPTQEGGPSQNALPSTQLDPGGGLMAQESSMKESPSWVTQRAQEMFQKTGTWSPERGPPIDMPNSQPNSQSVEMREMGTDGYSDSEHYLPMEGQTRAASMPRLPAENQRRRGRPRGNNLSTISDTSPMKRSASVLGPKARRLDDYSLERVPPEENQRYHQRRRDRGHRTSERSLGRYTDVDTGLGTDLSMTTQSGDLPSKDRDQDRGRPKDRKHRPHHHHHHHHHHPPAPDRERYAQERPDTGRARAREQRWSRSPSEGREHATHRQ
uniprot
proteins
function
FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q-type calcium currents. P/Q-type calcium channels belong to the 'high-voltage activated' (HVA) group and are specifically blocked by the spider omega-agatoxin-IVA (AC P30288) (PubMed:1311418). They are however insensitive to dihydropyridines (DHP). {ECO:0000250|UniProtKB:O00555, ECO:0000269|PubMed:1311418}.
uniprot
proteins
mass_dalton
251527
uniprot
proteins
protein_family
CACNA1A subfamily
uniprot
proteins
protein_family
Calcium channel alpha-1 subunit (TC 1.A.1.11) family
uniprot
proteins
pubmed
11865310
uniprot
proteins
pubmed
1279681
uniprot
proteins
pubmed
1311418
uniprot
proteins
pubmed
1648226
uniprot
proteins
pubmed
1692134
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
2212
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O00555}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 101..119; /note="Helical; Name=S1 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 139..156; /note="Helical; Name=S2 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 169..184; /note="Helical; Name=S3 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 193..211; /note="Helical; Name=S4 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 231..250; /note="Helical; Name=S5 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 338..362; /note="Helical; Name=S6 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 490..509; /note="Helical; Name=S1 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 524..543; /note="Helical; Name=S2 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 552..570; /note="Helical; Name=S3 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 581..599; /note="Helical; Name=S4 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 619..638; /note="Helical; Name=S5 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 692..716; /note="Helical; Name=S6 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 1191..1214; /note="Helical; Name=S1 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1232..1251; /note="Helical; Name=S2 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1259..1282; /note="Helical; Name=S3 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1294..1311; /note="Helical; Name=S4 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1331..1350; /note="Helical; Name=S5 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1438..1462; /note="Helical; Name=S6 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1519..1537; /note="Helical; Name=S1 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1552..1573; /note="Helical; Name=S2 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1581..1600; /note="Helical; Name=S3 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1608..1626; /note="Helical; Name=S4 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1646..1665; /note="Helical; Name=S5 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1738..1763; /note="Helical; Name=S6 of repeat IV"; /evidence="ECO:0000255
uniprot
proteins