SMOX
entrez
54498
canonical
uniprot
Q9NWM0
canonical
ensembl
ENSG00000088826
resolver
ensp
ENSP00000278795
resolver
ensp
ENSP00000307252
resolver
ensp
ENSP00000341775
resolver
ensp
ENSP00000344595
resolver
ensp
ENSP00000478305
resolver
ensp
ENSP00000627381
resolver
genesymbol
SMOX
resolver
genesymbol_syn
C20orf16
resolver
genesymbol_syn
SMO
resolver
hgnc
HGNC:15862
resolver
uniprot
A2A2P5
resolver
uniprot
A2A2P6
resolver
uniprot
A8BE87
resolver
uniprot
D3DVZ4
resolver
uniprot
Q5TE26
resolver
uniprot
Q5TE27
resolver
uniprot
Q6UY28
resolver
uniprot
Q8IX00
resolver
uniprot
Q96LC3
resolver
uniprot
Q96LC4
resolver
uniprot
Q96QT3
resolver
uniprot
Q9BW38
resolver
uniprot
Q9H6H1
resolver
uniprot
Q9NP51
resolver
uniprot
Q9NPY1
resolver
uniprot
Q9NPY2
resolver
uniprot_entry
SMOX_HUMAN
resolver
uniprot_sec
A2A2P5
resolver
uniprot_sec
A2A2P6
resolver
uniprot_sec
A8BE87
resolver
uniprot_sec
D3DVZ4
resolver
uniprot_sec
Q5TE26
resolver
uniprot_sec
Q5TE27
resolver
uniprot_sec
Q6UY28
resolver
uniprot_sec
Q8IX00
resolver
uniprot_sec
Q96LC3
resolver
uniprot_sec
Q96LC4
resolver
uniprot_sec
Q96QT3
resolver
uniprot_sec
Q9BW38
resolver
uniprot_sec
Q9H6H1
resolver
uniprot_sec
Q9NP51
resolver
uniprot_sec
Q9NPY1
resolver
uniprot_sec
Q9NPY2
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited at more than 90% by SL-11144, SL-11150 and SL-11158, at concentrations less than 1 uM.
uniprot
proteins
amino_acid_sequence
MQSCESSGDSADDPLSRGLRRRGQPRVVVIGAGLAGLAAAKALLEQGFTDVTVLEASSHIGGRVQSVKLGHATFELGATWIHGSHGNPIYHLAEANGLLEETTDGERSVGRISLYSKNGVACYLTNHGRRIPKDVVEEFSDLYNEVYNLTQEFFRHDKPVNAESQNSVGVFTREEVRNRIRNDPDDPEATKRLKLAMIQQYLKVESCESSSHSMDEVSLSAFGEWTEIPGAHHIIPSGFMRVVELLAEGIPAHVIQLGKPVRCIHWDQASARPRGPEIEPRGEGDHNHDTGEGGQGGEEPRGGRWDEDEQWSVVVECEDCELIPADHVIVTVSLGVLKRQYTSFFRPGLPTEKVAAIHRLGIGTTDKIFLEFEEPFWGPECNSLQFVWEDEAESHTLTYPPELWYRKICGFDVLYPPERYGHVLSGWICGEEALVMEKCDDEAVAEICTEMLRQFTGNPNIPKPRRILRSAWGSNPYFRGSYSYTQVGSSGADVEKLAKPLPYTESSKTAPMQVLFSGEATHRKYYSTTHGALLSGQREAARLIEMYRDLFQQGT
uniprot
proteins
ec_number
1.5.3.16
uniprot
proteins
function
FUNCTION: Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal.
uniprot
proteins
mass_dalton
61819
uniprot
proteins
mutagenesis
MUTAGEN 320; /note="C->R: No change in enzymatic activity."; /evidence="ECO:0000269|PubMed:12141946
uniprot
proteins
pathway_participation
PATHWAY: Amine and polyamine degradation; spermine degradation. {ECO:0000269|PubMed:12398765}.
uniprot
proteins
protein_family
Flavin monoamine oxidase family
uniprot
proteins
pubmed
11454677
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12141946
uniprot
proteins
pubmed
12398765
uniprot
proteins
pubmed
12727196
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15221502
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18422650
uniprot
proteins
sequence_length
555
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm. Nucleus.
uniprot
proteins