Slc16a7
entrez
20503
canonical
uniprot
O70451
canonical
ensembl
ENSMUSG00000020102
resolver
ensp
ENSMUSP00000065433
resolver
ensp
ENSMUSP00000100892
resolver
ensp
ENSMUSP00000147560
resolver
ensp
ENSMUSP00000147968
resolver
ensp
ENSMUSP00000240340
resolver
ensp
ENSMUSP00000240344
resolver
ensp
ENSMUSP00000240345
resolver
ensp
ENSMUSP00000240346
resolver
ensp
ENSMUSP00000240348
resolver
enst
ENSMUST00000063318
resolver
enst
ENSMUST00000105257
resolver
enst
ENSMUST00000210780
resolver
enst
ENSMUST00000211781
resolver
genesymbol
Slc16a7
resolver
genesymbol_syn
Mct2
resolver
uniprot
Q149G3
resolver
uniprot_entry
MOT2_MOUSE
resolver
uniprot_entry
Q149G3_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Transport activity exhibits steep dependence on substrate concentration. Substrate concentration sensitivity of SLC16A7 arises from the strong inter-subunit cooperativity of the SLC16A7 dimer during transport. Inhibited by AR-C155858. {ECO:0000250|UniProtKB:O60669}.
uniprot
proteins
amino_acid_sequence
MPSEPSAPLPQPLPPDGGWGWVVVCASFISIGFSYAFPKAVTVFFKDIQEIFNTTSSQIAWISSIMLAVMYAGGPISSVLVNNYGSRPVVIVGGLLCCIGMILASYSNSVIELYLTVGFIGGLGLAFNLQPALTIIGKYFYRRRPLANGCAMAGSPVFLSTLAPFNQYLFNNYGWKGSFLILGGIFLHSCVAGCLMRPVGPSPNTKKSKSKVGSRHDSTLKKASKVSTAQKVNRFLDFSLFMHRGFLIYLSGNVILFLGIFAPIIFLAQYAKHIGVDDYNSAFLLSVMAFIDMFARPSVGLIANTSLIRPRIQYLFSSAIIFTGICHLLCPLATTYSALVVYVVFFGLGFGSISSLLFECLMDIVGATRFSSAVGLTTIVECCPVLFGPPLAGKLLDITGEYKYLYIASGTVVLVSGTYLLIGNAINYRLLDKERKREKAKKKKSASHASREMEALNRSKQDEVTVKASNAHNPPSDRDKESNI
uniprot
proteins
function
FUNCTION: Proton-coupled monocarboxylate symporter (PubMed:21792931). Catalyzes the rapid transport across the plasma membrane of monocarboxylates such as L-lactate, pyruvate and ketone bodies, acetoacetate, beta-hydroxybutyrate and acetate. Dimerization is functionally required and both subunits work cooperatively in transporting substrate (By similarity). {ECO:0000250|UniProtKB:O60669, ECO:0000269|PubMed:21792931}.
uniprot
proteins
mass_dalton
52604
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Monocarboxylate porter (TC 2.A.1.13) family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17496809
uniprot
proteins
pubmed
21792931
uniprot
proteins
pubmed
9725820
uniprot
proteins
sequence_length
484
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O60669}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O60669}. Cytoplasm {ECO:0000269|PubMed:21792931}. Basolateral cell membrane {ECO:0000250|UniProtKB:P53988}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O60669}. Note=Requires the ancillary protein, EMB for plasma membrane localization (By similarity). Colocalizes with BSG in spermatozoa. Detected in the cytoplasm of Sertoli cells (PubMed:21792931). {ECO:0000250|UniProtKB:Q63344, ECO:0000269|PubMed:21792931}.
uniprot
proteins
transmembrane_region
TRANSMEM 17..37; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 61..81; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 91..111; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 117..137; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 150..170; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 175..195; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 246..266; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 282..302; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 312..332; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 338..358; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 373..393; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 406..426; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins