Acsl1
entrez
25288
canonical
uniprot
P18163
canonical
ensembl
ENSRNOG00000010633
resolver
ensembl
ENSRNOG00055011492
resolver
ensembl
ENSRNOG00060007558
resolver
ensembl
ENSRNOG00065015240
resolver
ensp
ENSRNOP00000014235
resolver
ensp
ENSRNOP00000072677
resolver
ensp
ENSRNOP00000108734
resolver
ensp
ENSRNOP00055015744
resolver
ensp
ENSRNOP00060009454
resolver
ensp
ENSRNOP00065019775
resolver
enst
ENSRNOT00000014235
resolver
enst
ENSRNOT00000089501
resolver
enst
ENSRNOT00000164041
resolver
enst
ENSRNOT00055019523
resolver
enst
ENSRNOT00060012484
resolver
enst
ENSRNOT00065025247
resolver
genesymbol
Acsl1
resolver
genesymbol_syn
Acs1
resolver
genesymbol_syn
Acsl2
resolver
genesymbol_syn
Facl2
resolver
uniprot
A0A8L2R6L8
resolver
uniprot
A0ABK0LRZ6
resolver
uniprot_entry
A0A8L2R6L8_RAT
resolver
uniprot_entry
A0ABK0LRZ6_RAT
resolver
uniprot_entry
ACSL1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited at high temperature and by arachidonate. {ECO:0000269|PubMed:8978480}.
uniprot
proteins
amino_acid_sequence
MEVHELFRYFRMPELIDIRQYVRTLPTNTLMGFGAFAALTTFWYATRPKALKPPCDLSMQSVEVTGTTEGVRRSAVLEDDKLLLYYYDDVRTMYDGFQRGIQVSNDGPCLGSRKPNQPYEWISYKQVAEMAECIGSALIQKGFKPCSEQFIGIFSQNRPEWVTIEQGCFTYSMVVVPLYDTLGTDAITYIVNKAELSVIFADKPEKAKLLLEGVENKLTPCLKIIVIMDSYDNDLVERGQKCGVEIIGLKALEDLGRVNRTKPKPPEPEDLAIICFTSGTTGNPKGAMVTHQNIMNDCSGFIKATESAFIASPEDVLISFLPLAHMFETVVECVMLCHGAKIGFFQGDIRLLMDDLKVLQPTIFPVVPRLLNRMFDRIFGQANTSVKRWLLDFASKRKEAELRSGIVRNNSLWDKLIFHKIQSSLGGKVRLMITGAAPVSATVLTFLRAALGCQFYEGYGQTECTAGCCLSLPGDWTAGHVGAPMPCNYIKLVDVEDMNYQAAKGEGEVCVKGANVFKGYLKDPARTAEALDKDGWLHTGDIGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYLRSEAVAQVFVHGESLQAFLIAIVVPDVEILPSWAQKRGFQGSFEELCRNKDINKAILEDMVKLGKNAGLKPFEQVKGIAVHPELFSIDNGLLTPTLKAKRPELRNYFRSQIDELYSTIKI
uniprot
proteins
ec_number
6.2.1.15
uniprot
proteins
ec_number
6.2.1.24
uniprot
proteins
ec_number
6.2.1.3
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:10198260, PubMed:10749848, PubMed:28209804, PubMed:8978480). Preferentially uses palmitoleate, oleate and linoleate (By similarity). Preferentially activates arachidonate than epoxyeicosatrienoic acids (EETs) or hydroxyeicosatrienoic acids (HETEs) (PubMed:28209804). {ECO:0000250|UniProtKB:P33121, ECO:0000269|PubMed:10198260, ECO:0000269|PubMed:10749848, ECO:0000269|PubMed:28209804, ECO:0000269|PubMed:8978480}.
uniprot
proteins
mass_dalton
78179
uniprot
proteins
protein_family
ATP-dependent AMP-binding enzyme family
uniprot
proteins
pubmed
10198260
uniprot
proteins
pubmed
10749848
uniprot
proteins
pubmed
15683247
uniprot
proteins
pubmed
17478130
uniprot
proteins
pubmed
2341402
uniprot
proteins
pubmed
24098488
uniprot
proteins
pubmed
28209804
uniprot
proteins
pubmed
29196521
uniprot
proteins
pubmed
8973631
uniprot
proteins
pubmed
8978480
uniprot
proteins
sequence_length
699
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P33121}; Single-pass type III membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..45; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins