Neu3
entrez
50877
canonical
uniprot
Q9JMH7
canonical
ensembl
ENSMUSG00000035239
resolver
ensp
ENSMUSP00000045222
resolver
ensp
ENSMUSP00000160085
resolver
enst
ENSMUST00000036331
resolver
enst
ENSMUST00000250002
resolver
genesymbol
Neu3
resolver
uniprot
Q543I9
resolver
uniprot_entry
NEUR3_MOUSE
resolver
uniprot_entry
Q543I9_MOUSE
resolver
amino_acid_sequence
MEEVPPYSLSSTLFQQEEQSGVTYRIPALLYLPPTHTFLAFAEKRTSVRDEDAACLVLRRGLMKGRSVQWGPQRLLMEATLPGHRTMNPCPVWEKNTGRVYLFFICVRGHVTERCQIVWGKNAARLCFLCSEDAGCSWGEVKDLTEEVIGSEVKRWATFAVGPGHGIQLHSGRLIIPAYAYYVSRWFLCFACSVKPHSLMIYSDDFGVTWHHGKFIEPQVTGECQVAEVAGTAGNPVLYCSARTPSRFRAEAFSTDSGGCFQKPTLNPQLHEPRTGCQGSVVSFRPLKMPNTYQDSIGKGAPATQKCPLLDSPLEVEKGAETPSATWLLYSHPTSKRKRINLGIYYNRNPLEVNCWSRPWILNRGPSGYSDLAVVEEQDLVACLFECGEKNEYERIDFCLFSDHEVLSCEDCTSPSSD
uniprot
proteins
ec_number
3.2.1.18
uniprot
proteins
function
FUNCTION: Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosaccharides. Displays high catalytic efficiency for gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:10713120, PubMed:11696012, PubMed:14970224, PubMed:17708748). Plays a role in the regulation of transmembrane signaling through the modulation of ganglioside content of the lipid bilayer and by direct interaction with signaling receptors, such as EGFR. Desialylates EGFR and activates downstream signaling in proliferating cells. Contributes to clathrin-mediated endocytosis by regulating sorting of endocytosed receptors to early and recycling endosomes (By similarity). {ECO:0000250|UniProtKB:Q9UQ49, ECO:0000269|PubMed:10713120, ECO:0000269|PubMed:11696012, ECO:0000269|PubMed:17708748}.
uniprot
proteins
mass_dalton
46846
uniprot
proteins
post_translational_modification
PTM: Palmitoylated; may regulate intracellular trafficking and anchorage to plasma membrane and endomembranes. {ECO:0000250|UniProtKB:Q9UQ49}.
uniprot
proteins
protein_family
Glycosyl hydrolase 33 family
uniprot
proteins
pubmed
10713120
uniprot
proteins
pubmed
11696012
uniprot
proteins
pubmed
14970224
uniprot
proteins
pubmed
17708748
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
418
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14970224, ECO:0000269|PubMed:17708748}; Peripheral membrane protein {ECO:0000269|PubMed:17708748}. Membrane, caveola {ECO:0000250|UniProtKB:Q9UQ49}. Early endosome membrane {ECO:0000269|PubMed:17708748}; Peripheral membrane protein {ECO:0000269|PubMed:17708748}. Recycling endosome membrane {ECO:0000269|PubMed:17708748}; Peripheral membrane protein {ECO:0000269|PubMed:17708748}. Lysosome membrane {ECO:0000250|UniProtKB:Q9UQ49}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9UQ49}. Note=Associates with the external leaflet of the plasma membrane (PubMed:17708748). S-acylated NEU3 likely spans the lipid bilayer with a portion of C-terminus exposed to cytosol and the catalytic region facing the extracellular space (By similarity). {ECO:0000250|UniProtKB:Q9UQ49, ECO:0000269|PubMed:17708748}.
uniprot
proteins