Babam1
entrez
290631
canonical
uniprot
Q5XIJ6
canonical
ensembl
ENSRNOG00000017071
resolver
ensembl
ENSRNOG00055010549
resolver
ensembl
ENSRNOG00060011253
resolver
ensembl
ENSRNOG00065000640
resolver
ensembl
ENSRNOG00065020442
resolver
ensp
ENSRNOP00000022938
resolver
ensp
ENSRNOP00055014391
resolver
ensp
ENSRNOP00060014845
resolver
ensp
ENSRNOP00065000738
resolver
ensp
ENSRNOP00065027706
resolver
enst
ENSRNOT00000022938
resolver
enst
ENSRNOT00055017868
resolver
enst
ENSRNOT00060019022
resolver
enst
ENSRNOT00065000909
resolver
enst
ENSRNOT00065034558
resolver
genesymbol
Babam1
resolver
genesymbol_syn
Merit40
resolver
genesymbol_syn
Nba1
resolver
uniprot_entry
BABA1_RAT
resolver
amino_acid_sequence
MEVAEANSPTEEEEEEEEEEGEEPISEPRPHTRSNPEGAEDRAIGAQANVGSRSEGEGEAATADDGAASVPGAVPKPWQVPAPASEVQIRTPRVNCPEKVIICLDLSEEMSVPKLESFNGSRTNALNVSQKMVEMFVRTKHKIDKSHEFALVVVNDDSAWLSGLTSDPRELCSCLYDLETASCSTFNLEGLFSLIQQKTELPVTENVQTIPPPYVVRTILVYSRPPCQPQFSLTEPMKKMFQCPYFFFDIIYIHSGPEEKEDDMSWKDMFAFMGSLDTKGTSYKYAVALAGPALELHNCVAKLLAHPLQRPCQSHASYSLLEEDEEAGEGEATV
uniprot
proteins
function
FUNCTION: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. {ECO:0000250|UniProtKB:Q9NWV8}.
uniprot
proteins
mass_dalton
36878
uniprot
proteins
protein_family
BABAM1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
334
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9NWV8}. Nucleus {ECO:0000250|UniProtKB:Q9NWV8}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). {ECO:0000250|UniProtKB:Q9NWV8}.
uniprot
proteins