RBM25
entrez
58517
canonical
uniprot
P49756
canonical
ensembl
ENSG00000119707
resolver
ensp
ENSP00000261973
resolver
ensp
ENSP00000597403
resolver
genesymbol
RBM25
resolver
genesymbol_syn
RNPC7
resolver
hgnc
HGNC:23244
resolver
uniprot
A0PJL9
resolver
uniprot
B2RNA8
resolver
uniprot
B3KT03
resolver
uniprot
Q2TA72
resolver
uniprot
Q5XJ17
resolver
uniprot
Q6P665
resolver
uniprot
Q9H6A1
resolver
uniprot
Q9UEQ5
resolver
uniprot
Q9UIE9
resolver
uniprot_entry
RBM25_HUMAN
resolver
uniprot_sec
A0PJL9
resolver
uniprot_sec
B2RNA8
resolver
uniprot_sec
B3KT03
resolver
uniprot_sec
Q2TA72
resolver
uniprot_sec
Q5XJ17
resolver
uniprot_sec
Q6P665
resolver
uniprot_sec
Q9H6A1
resolver
uniprot_sec
Q9UEQ5
resolver
uniprot_sec
Q9UIE9
resolver
amino_acid_sequence
MSFPPHLNRPPMGIPALPPGIPPPQFPGFPPPVPPGTPMIPVPMSIMAPAPTVLVPTVSMVGKHLGARKDHPGLKAKENDENCGPTTTVFVGNISEKASDMLIRQLLAKCGLVLSWKRVQGASGKLQAFGFCEYKEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLRPISSAPSVSSASGNATPNTPGDESPCGIIIPHENSPDQQQPEEHRPKIGLSLKLGASNSPGQPNSVKRKKLPVDSVFNKFEDEDSDDVPRKRKLVPLDYGEDDKNATKGTVNTEEKRKHIKSLIEKIPTAKPELFAYPLDWSIVDSILMERRIRPWINKKIIEYIGEEEATLVDFVCSKVMAHSSPQSILDDVAMVLDEEAEVFIVKMWRLLIYETEAKKIGLVK
uniprot
proteins
function
FUNCTION: RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing. Involved in apoptotic cell death through the regulation of the apoptotic factor BCL2L1 isoform expression. Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression. When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5'-splice site (5'-ss) selection, whereas its depletion caused the accumulation of antiapoptotic BCL2L1 isoform L. Promotes BCL2L1 isoform S 5'-ss usage through the 5'-CGGGCA-3' RNA sequence. Its association with LUC7L3 promotes U1 snRNP binding to a weak 5' ss in a 5'-CGGGCA-3'-dependent manner. Binds to the exonic splicing enhancer 5'-CGGGCA-3' RNA sequence located within exon 2 of the BCL2L1 pre-mRNA. Also involved in the generation of an abnormal and truncated splice form of SCN5A in heart failure. {ECO:0000269|PubMed:18663000, ECO:0000269|PubMed:21859973}.
uniprot
proteins
mass_dalton
100185
uniprot
proteins
mutagenesis
MUTAGEN 734..736; /note="KRK->AAA: Reduced DNA/RNA binding."; /evidence="ECO:0000269|PubMed:23190262"; MUTAGEN 777..778; /note="KK->AA: Reduced DNA/RNA binding."; /evidence="ECO:0000269|PubMed:23190262"; MUTAGEN 825; /note="K->A: Reduced DNA/RNA binding; when associated with A-828."; /evidence="ECO:0000269|PubMed:23190262"; MUTAGEN 828; /note="R->A: Reduced DNA/RNA binding; when associated with A-825."; /evidence="ECO:0000269|PubMed:23190262
uniprot
proteins
post_translational_modification
PTM: Sumoylated. {ECO:0000269|PubMed:15561718}.
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15561718
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17560998
uniprot
proteins
pubmed
18663000
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21859973
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23190262
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
7596406
uniprot
proteins
sequence_length
843
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle. Cytoplasm. Note=Colocalizes predominantly, with SFRS2 and LUC7L3 splicing factors, in nuclear speckles. Cytoplasmic localization is faint.
uniprot
proteins