Ncoa7
entrez
211329
canonical
uniprot
Q6DFV7
canonical
ensembl
ENSMUSG00000039697
resolver
ensp
ENSMUSP00000066741
resolver
ensp
ENSMUSP00000149957
resolver
ensp
ENSMUSP00000150021
resolver
ensp
ENSMUSP00000150981
resolver
ensp
ENSMUSP00000213839
resolver
ensp
ENSMUSP00000213844
resolver
ensp
ENSMUSP00000213845
resolver
enst
ENSMUST00000213836
resolver
enst
ENSMUST00000215926
resolver
genesymbol
Ncoa7
resolver
uniprot
A0A1L1SSL1
resolver
uniprot
A0A1L1SSS4
resolver
uniprot
A9Q6S9
resolver
uniprot
B9EIW5
resolver
uniprot
Q3TAR1
resolver
uniprot
Q3UNB3
resolver
uniprot
Q66K05
resolver
uniprot
Q6ZQM4
resolver
uniprot
Q8BJ15
resolver
uniprot
Q8BJ39
resolver
uniprot_entry
A0A1L1SSL1_MOUSE
resolver
uniprot_entry
A0A1L1SSS4_MOUSE
resolver
uniprot_entry
B9EIW5_MOUSE
resolver
uniprot_entry
NCOA7_MOUSE
resolver
uniprot_sec
A9Q6S9
resolver
uniprot_sec
Q3TAR1
resolver
uniprot_sec
Q3UNB3
resolver
uniprot_sec
Q66K05
resolver
uniprot_sec
Q6ZQM4
resolver
uniprot_sec
Q8BJ15
resolver
uniprot_sec
Q8BJ39
resolver
amino_acid_sequence
MDTKEEKKEQKERKQSYFARLKKKKQAKQNAEIVSAASSKSRSGKDDANSDILEQDKFNVTAEGDHSTDDKKKRKSNQLKEIRRTELKRYYSVDDNQNKTHDKKEKKMMVQKPQGTMEYTAGSQDTLNSVALKFNVTPNKLVELNKLFTHTIVPGQVLFVPDANISSSTIQLSSSTPGATVSPSSSDAEYDKLPDADLARKALKPIERVLSSTSEEDEPGVVKFLKMNCRYFTDGKGVVGGVMIVTPNNIMFDPHKSDPLVIENGCEEYGLICPMEEVVSIALYSDISHMKIKDALPSDLPRDLCPLYRPGEWEDLASEKDINPFSKFKSINKEKRQQNGERTLALDAKSVRSPEESTERTCTRIEPPDNSELWKLKNLQSSRGTTSESPSVTQLSMRAALEPTAKENCLLKGDEDFVDLEELSSQPESGINKGDATKECLSYDQKKDGPHTVMSAKKGHVQSAQEVMGPESDTELKGALDLETAEKQDEAPEVDKHSGSPENLGESTLNIHEDLDKIKLIEFYLNKNKEGSQLLENVQKSELSDRKSIEPGGIDITLSSSLPQAGDSPPEDNKEPGTLWVKGGETLPLKLDPSAEETVINNKEVLDSLGSSLDKMCHSAQMDNKSEIQLWLLKRIQVPIEDILPSKEEKSKTPPMFLCIKVGKPMRKSFASHTATMVQQYSKRRKQPEYWFAVPRERVDHLYTFFVQWSPDVYGKDAKEQGFVVVEKEELNMIDNFFSEPTTKSWEIITVEEAKRRKSTCSYYEEEEEEEEGLPILQPHSALLENMHIEQLARRLPARVQGYPWRLAYSTLEHGTSLKTLYRKSASLDSPVLLVIKDMDNQIFGAYATHPFKFSDHYYGTGETFLYTFSPNFKVFKWSGENSYFINGDISSLELGGGGGRFGLWLDADLYHGRSNSCSTFNNDILSKKEDFIVQDLEVWTFE
uniprot
proteins
function
FUNCTION: Transcriptional coactivator which enhances the transcriptional activities of several nuclear receptors including ESR1, THRB, PPARG and RARA (By similarity). Inhibits the activity of the vacuolar-type ATPase (V-ATPase) by inducing disassembly of the V-ATPase complex (By similarity). Protects the Golgi apparatus lumen from excess acidification by inhibiting V-ATPase ATP hydrolytic activity through interaction with V-ATPase catalytic subunit ATP6V1A, maintaining optimal conditions for glycosylation enzymes (PubMed:40445757). Required to stabilize V-ATPase V1 subunits ATP6V1B2 and ATP6V1A at membrane sites (PubMed:33340069). Involved in protection against oxidative damage (PubMed:26668325). Involved in urine acidification (PubMed:29384414). {ECO:0000250|UniProtKB:Q8NI08, ECO:0000269|PubMed:26668325, ECO:0000269|PubMed:29384414, ECO:0000269|PubMed:33340069, ECO:0000269|PubMed:40445757}.; FUNCTION: [Isoform 1]: Exhibits oxidation resistance activity (PubMed:26668325). Protects neuronal cells from oxidative stress with weaker neuroprotective activity than isoform 3 (PubMed:26668325). {ECO:0000269|PubMed:26668325}.; FUNCTION: [Isoform 3]: Exhibits oxidation resistance activity (PubMed:26668325). Protects neuronal cells from oxidative stress with stronger neuroprotective activity than isoform 1 (PubMed:26668325). Inhibits endosome-mediated viral entry by inhibiting fusion of the viral and endosomal membranes and subsequent nuclear translocation of viral ribonucleoproteins (By similarity). Promotes increased cytoplasmic vesicular acidification, lysosomal protease activity and the degradation of endocytosed material (By similarity). {ECO:0000250|UniProtKB:Q8NI08, ECO:0000269|PubMed:26668325}.
uniprot
proteins
mass_dalton
106357
uniprot
proteins
mutagenesis
MUTAGEN Q6DFV7-3:93; /note="G->A: Increases cellular oxidative stress compared to wild-type. Increases levels of S-nitrosylated proteins in neurons. Abolishes interaction with Atp6v1b1."; /evidence="ECO:0000269|PubMed:26668325, ECO:0000269|PubMed:34811399"; MUTAGEN Q6DFV7-3:95; /note="S->A: Increases cellular oxidative stress compared to wild-type. Increases levels of S-nitrosylated proteins in neurons. Reduces interaction with Atp6v1b1."; /evidence="ECO:0000269|PubMed:26668325, ECO:0000269|PubMed:34811399"; MUTAGEN Q6DFV7-3:123; /note="G->A: Reduces cellular oxidative stress more than wild-type. Reduces levels of S-nitrosylated proteins in neurons. Abolishes interaction with Atp6v1b1."; /evidence="ECO:0000269|PubMed:26668325, ECO:0000269|PubMed:34811399"; MUTAGEN Q6DFV7-3:174; /note="G->A: Reduces cellular oxidative stress similar to wild-type. Slightly increases levels of S-nitrosylated proteins in neurons. Abolishes interaction with Atp6v1b1."; /evidence="ECO:0000269|PubMed:26668325, ECO:0000269|PubMed:34811399"; MUTAGEN Q6DFV7-3:204; /note="L->A: Increases cellular oxidative stress compared to wild-type. Increases levels of S-nitrosylated proteins in neurons. Reduces interaction with Atp6v1b1."; /evidence="ECO:0000269|PubMed:26668325, ECO:0000269|PubMed:34811399"; MUTAGEN Q6DFV7-3:216; /note="E->A: Reduces cellular oxidative stress similar to wild-type. Increases levels of S-nitrosylated proteins in neurons. Reduces interaction with Atp6v1b1."; /evidence="ECO:0000269|PubMed:26668325, ECO:0000269|PubMed:34811399
uniprot
proteins
protein_family
OXR1 family
uniprot
proteins
pubmed
11971969
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18299425
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26668325
uniprot
proteins
pubmed
29384414
uniprot
proteins
pubmed
33340069
uniprot
proteins
pubmed
34811399
uniprot
proteins
pubmed
40445757
uniprot
proteins
sequence_length
943
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8NI08}. Cytoplasm {ECO:0000269|PubMed:33340069}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:40445757}; Peripheral membrane protein {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:40445757}; Peripheral membrane protein {ECO:0000305}. Note=Predominantly nuclear following estradiol stimulation (By similarity). Localizes to the nucleus and cytoplasm in the absence of estradiol (By similarity). Recruited to the cis-Golgi network and trans-Golgi network membranes in a Rab-dependent manner (PubMed:40445757). {ECO:0000250|UniProtKB:Q8NI08, ECO:0000269|PubMed:40445757}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:26668325}.
uniprot
proteins