Mpl
entrez
17480
canonical
uniprot
Q08351
canonical
ensembl
ENSMUSG00000006389
resolver
ensp
ENSMUSP00000006556
resolver
ensp
ENSMUSP00000099732
resolver
ensp
ENSMUSP00000101983
resolver
ensp
ENSMUSP00000130167
resolver
enst
ENSMUST00000006556
resolver
enst
ENSMUST00000168404
resolver
genesymbol
Mpl
resolver
genesymbol_syn
Tpor
resolver
uniprot
A2A9D4
resolver
uniprot
A6H8H6
resolver
uniprot
E9Q7U5
resolver
uniprot
Q8BRX0
resolver
uniprot_entry
A2A9D4_MOUSE
resolver
uniprot_entry
E9Q7U5_MOUSE
resolver
uniprot_entry
TPOR_MOUSE
resolver
uniprot_sec
A6H8H6
resolver
uniprot_sec
Q8BRX0
resolver
amino_acid_sequence
MPSWALFMVTSCLLLALPNQAQVTSQDVFLLALGTEPLNCFSQTFEDLTCFWDEEEAAPSGTYQLLYAYRGEKPRACPLYSQSVPTFGTRYVCQFPAQDEVRLFFPLHLWVKNVSLNQTLIQRVLFVDSVGLPAPPRVIKARGGSQPGELQIHWEAPAPEISDFLRHELRYGPTDSSNATAPSVIQLLSTETCCPTLWMPNPVPVLDQPPCVHPTASQPHGPAPFLTVKGGSCLVSGLQAGKSYWLQLRSQPDGVSLRGSWGPWSFPVTVDLPGDAVTIGLQCFTLDLKMVTCQWQQQDRTSSQGFFRHSRTRCCPTDRDPTWEKCEEEEPRPGSQPALVSRCHFKSRNDSVIHILVEVTTAQGAVHSYLGSPFWIHQAVLLPTPSLHWREVSSGRLELEWQHQSSWAAQETCYQLRYTGEGREDWKVLEPSLGARGGTLELRPRARYSLQLRARLNGPTYQGPWSAWSPPARVSTGSETAWITLVTALLLVLSLSALLGLLLLKWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPSKATVTDSCEEVEPSLLEILPKSSESTPLPLCPSQPQMDYRGLQPCLRTMPLSVCPPMAETGSCCTTHIANHSYLPLSYWQQP
uniprot
proteins
function
FUNCTION: Receptor for thrombopoietin that regulates hematopoietic stem cell renewal, megakaryocyte differentiation, and platelet formation (PubMed:8630375, PubMed:9122198, PubMed:9639492). Upon activation by THPO, induces rapid tyrosine phosphorylation and activation of JAK2, providing docking sites for many signaling proteins such as STAT5, SHIP/INPP5D, GRB2, SOS1 and PI3K. In turn, These signaling cascades lead to the proliferation, survival, and differentiation of megakaryocytes, ultimately leading to increased platelet production. {ECO:0000269|PubMed:15210714, ECO:0000269|PubMed:8630375, ECO:0000269|PubMed:9122198, ECO:0000269|PubMed:9639492}.; FUNCTION: [Isoform Mpl-tr]: Acts as an inhibitor of thrombopoietin signaling by promoting protein down-regulation of full-length isoform Mpl-fl. {ECO:0000269|PubMed:15210714}.
uniprot
proteins
mass_dalton
69788
uniprot
proteins
mutagenesis
MUTAGEN 104; /note="F->S: Completely abrogated binding to THPO."; /evidence="ECO:0000269|PubMed:38326297
uniprot
proteins
post_translational_modification
PTM: Ubiquitination at Lys-544 and Lys-564 targets MPL for degradation by both the lysosomal and proteasomal pathways. The E3 ubiquitin-protein ligase CBL significantly contributes to this ubiquitination. {ECO:0000250|UniProtKB:P40238}.
uniprot
proteins
protein_family
Type 1 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
15210714
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22284746
uniprot
proteins
pubmed
25468569
uniprot
proteins
pubmed
38326297
uniprot
proteins
pubmed
8334987
uniprot
proteins
pubmed
8397366
uniprot
proteins
pubmed
8630375
uniprot
proteins
pubmed
9122198
uniprot
proteins
pubmed
9639492
uniprot
proteins
sequence_length
625
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P40238}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P40238}. Golgi apparatus {ECO:0000250|UniProtKB:P40238}. Cell surface {ECO:0000250|UniProtKB:P40238}.
uniprot
proteins
transmembrane_region
TRANSMEM 483..504; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins