MCF2
entrez
4168
canonical
uniprot
P10911
canonical
ensembl
ENSG00000101977
resolver
ensp
ENSP00000342204
resolver
ensp
ENSP00000359605
resolver
ensp
ENSP00000359608
resolver
ensp
ENSP00000397055
resolver
ensp
ENSP00000405848
resolver
ensp
ENSP00000427745
resolver
ensp
ENSP00000430276
resolver
ensp
ENSP00000438155
resolver
genesymbol
MCF2
resolver
genesymbol_syn
DBL
resolver
hgnc
HGNC:6940
resolver
uniprot
B2R9S6
resolver
uniprot
B7Z3Y5
resolver
uniprot
B7Z869
resolver
uniprot
B7ZAV1
resolver
uniprot
E9PH77
resolver
uniprot
F5H091
resolver
uniprot
P14919
resolver
uniprot
Q5JYJ2
resolver
uniprot
Q5JYJ3
resolver
uniprot
Q5JYJ4
resolver
uniprot
Q8IUF3
resolver
uniprot
Q8IUF4
resolver
uniprot
Q9UJB3
resolver
uniprot_entry
B2R9S6_HUMAN
resolver
uniprot_entry
MCF2_HUMAN
resolver
uniprot_sec
B7Z3Y5
resolver
uniprot_sec
B7Z869
resolver
uniprot_sec
B7ZAV1
resolver
uniprot_sec
E9PH77
resolver
uniprot_sec
F5H091
resolver
uniprot_sec
P14919
resolver
uniprot_sec
Q5JYJ2
resolver
uniprot_sec
Q5JYJ3
resolver
uniprot_sec
Q5JYJ4
resolver
uniprot_sec
Q8IUF3
resolver
uniprot_sec
Q8IUF4
resolver
uniprot_sec
Q9UJB3
resolver
amino_acid_sequence
MAEANPRRGKMRFRRNAASFPGNLHLVLVLRPTSFLQRTFTDIGFWFSQEDFMLKLPVVMLSSVSDLLTYIDDKQLTPELGGTLQYCHSEWIIFRNAIENFALTVKEMAQMLQSFGTELAETELPDDIPSIEEILAIRAERYHLLKNDITAVTKEGKILLTNLEVPDTEGAVSSRLECHRQISGDWQTINKLLTQVHDMETAFDGFWEKHQLKMEQYLQLWKFEQDFQQLVTEVEFLLNQQAELADVTGTIAQVKQKIKKLENLDENSQELLSKAQFVILHGHKLAANHHYALDLICQRCNELRYLSDILVNEIKAKRIQLSRTFKMHKLLQQARQCCDEGECLLANQEIDKFQSKEDAQKALQDIENFLEMALPFINYEPETLQYEFDVILSPELKVQMKTIQLKLENIRSIFENQQAGFRNLADKHVRPIQFVVPTPENLVTSGTPFFSSKQGKKTWRQNQSNLKIEVVPDCQEKRSSGPSSSLDNGNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGNMAEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKYSECAFFQECQRKLKHRLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKKALDAMLDLLKSVNDSMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGATKMKDLARFKPMQRHLFLYEKAIVFCKRRVESGEGSDRYPSYSFKHCWKMDEVGITEYVKGDNRKFEIWYGEKEEVYIVQASNVDVKMTWLKEIRNILLKQQELLTVKKRKQQDQLTERDKFQISLQQNDEKQQGAFISTEETELEHTSTVVEVCEAIASVQAEANTVWTEASQSAEISEEPAEWSSNYFYPTYDENEEENRPLMRPVSEMALLY
uniprot
proteins
disease_involvement
DISEASE: Note=MCF2 and DBL represent two activated versions of the same proto-oncogene. {ECO:0000305}.
uniprot
proteins
function
FUNCTION: Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42.
uniprot
proteins
mass_dalton
107673
uniprot
proteins
mutagenesis
MUTAGEN 640..646; /note="LLLKELL->IIIRDII: Transformation capability reduced; no stimulation of GDP dissociation."; /evidence="ECO:0000269|PubMed:2065022
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by TNK2 enhances guanine nucleotide exchange factor (GEF) activity toward Rho family proteins. {ECO:0000269|PubMed:10652228}.
uniprot
proteins
protein_family
MCF2 family
uniprot
proteins
pubmed
10652228
uniprot
proteins
pubmed
12445822
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15157669
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
17000758
uniprot
proteins
pubmed
2065022
uniprot
proteins
pubmed
2577874
uniprot
proteins
pubmed
3056717
uniprot
proteins
pubmed
3281159
uniprot
proteins
pubmed
8276860
uniprot
proteins
sequence_length
925
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15157669}.; SUBCELLULAR LOCATION: [Isoform 1]: Membrane.; SUBCELLULAR LOCATION: [Isoform 3]: Membrane. Note=Colocalizes with CDC42 to plasma membrane.
uniprot
proteins