Fen1
entrez
84490
canonical
uniprot
Q5XIP6
canonical
ensembl
ENSRNOG00000020531
resolver
ensembl
ENSRNOG00055017939
resolver
ensembl
ENSRNOG00060030600
resolver
ensembl
ENSRNOG00065033963
resolver
ensp
ENSRNOP00000027842
resolver
ensp
ENSRNOP00000078106
resolver
ensp
ENSRNOP00055024436
resolver
ensp
ENSRNOP00055024438
resolver
ensp
ENSRNOP00055024439
resolver
ensp
ENSRNOP00060044203
resolver
ensp
ENSRNOP00060044207
resolver
ensp
ENSRNOP00060044214
resolver
ensp
ENSRNOP00065048016
resolver
ensp
ENSRNOP00065048017
resolver
ensp
ENSRNOP00065048018
resolver
enst
ENSRNOT00000027842
resolver
enst
ENSRNOT00000106648
resolver
enst
ENSRNOT00055030381
resolver
enst
ENSRNOT00055030383
resolver
enst
ENSRNOT00055030384
resolver
enst
ENSRNOT00060053157
resolver
enst
ENSRNOT00060053163
resolver
enst
ENSRNOT00060053171
resolver
enst
ENSRNOT00065058340
resolver
enst
ENSRNOT00065058341
resolver
enst
ENSRNOT00065058342
resolver
genesymbol
Fen1
resolver
uniprot
Q9JHW7
resolver
uniprot_entry
FEN1_RAT
resolver
uniprot_sec
Q9JHW7
resolver
amino_acid_sequence
MGIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGDVLQNEEGETTSHLMGMFYRTIRMMENGIKPVYIFDGKPPQLKSGELAKRSERRAEAEKQLQQAQEAGAEEEVEKFTKRLVKVTKQHNDECKHLLSLMGIPYLDAPSEAEASCAALAKAGKVYAAATEDMDCLTFGSPVLMRHLTASEAKKLPIQEFHLSRVLQELGLNQEQFVDLCILLGSDYCESVRGIGPKRAVDLIQKHKSIEEIVRRLDPSKYPVPENWLHKEARQLFLEPEVLDPESVELKWSEPNEEELVKFMCGEKQFSEERIRSGVKRLNKSRQGSTQGRLDDFFKVTGSLSSAKRKEPEPKGPAKKKAKTGGAGKFRRGK
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA. {ECO:0000255|HAMAP-Rule:MF_03140}.
uniprot
proteins
mass_dalton
42609
uniprot
proteins
post_translational_modification
PTM: Acetylated by EP300. Acetylation inhibits both endonuclease and exonuclease activity. Acetylation also reduces DNA-binding activity but does not affect interaction with PCNA or EP300. {ECO:0000255|HAMAP-Rule:MF_03140}.; PTM: Phosphorylation upon DNA damage induces relocalization to the nuclear plasma. Phosphorylation at Ser-187 by CDK2 occurs during late S-phase and results in dissociation from PCNA. {ECO:0000255|HAMAP-Rule:MF_03140}.; PTM: Methylation at Arg-192 by PRMT5 impedes Ser-187 phosphorylation and increases interaction with PCNA. {ECO:0000255|HAMAP-Rule:MF_03140}.
uniprot
proteins
protein_family
FEN1 subfamily
uniprot
proteins
protein_family
XPG/RAD2 endonuclease family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
380
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000255|HAMAP-Rule:MF_03140}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03140}. Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03140}. Note=Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage. {ECO:0000255|HAMAP-Rule:MF_03140}.
uniprot
proteins