Scn8a
entrez
29710
canonical
uniprot
O88420
canonical
ensembl
ENSRNOG00000005309
resolver
ensembl
ENSRNOG00055027400
resolver
ensembl
ENSRNOG00065021763
resolver
ensp
ENSRNOP00000008160
resolver
ensp
ENSRNOP00000082508
resolver
enst
ENSRNOT00000008160
resolver
enst
ENSRNOT00000114577
resolver
genesymbol
Scn8a
resolver
uniprot
A0A8I5ZX68
resolver
uniprot
F1LMH2
resolver
uniprot
O88421
resolver
uniprot_entry
A0A8I5ZX68_RAT
resolver
uniprot_entry
F1LMH2_RAT
resolver
uniprot_entry
SCN8A_RAT
resolver
uniprot_sec
O88421
resolver
amino_acid_sequence
MAARLLAPPGPDSFKPFTPESLANIERRIAESKLKKPPKADGSHREDDEDSKPKPNSDLEAGKSLPFIYGDIPQGLVAVPLEDFDPYYLTQKTFVVLNRGKTLFRFSATPALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPEWSKNVEYTFTGIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNESYLENGTRGFDWEEYINNKTNFYMVPGMLEPLLCGNSSDAGQCPEGFQCMKAGRNPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTYMIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEDGVGSPRSSSELSKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFRLPDNRIGRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRDSLFIPIRARERRSSYSGYSGYSQCSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGPGSHIGRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQECKLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWTKVKVHAFMQAHFKQREADEVKPLDELYEKKANCIANHTGVDIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDFENLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILEYADKVFTYIFILEMLLKWTAYGFVKFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYCFNETSEIRFEIDIVNNKTDCEKLMEGNSTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPDYEGNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEHPGSGFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFADALEHPLRVPKPNTIELIAMDLPMVSGDRIHCLDILFAFTKRVLGDSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARRGFICRKMASNKLENGGTHRDKKESTPSTASLPSYDSVTKPDKEKQQRAEEGRRERAKRQKEVRESKC
uniprot
proteins
function
FUNCTION: Pore-forming subunit of a voltage-gated sodium channel complex assuming opened or closed conformations in response to the voltage difference across membranes and through which sodium ions selectively pass along their electrochemical gradient. Contributes to neuronal excitability by regulating action potential threshold and propagation. {ECO:0000269|PubMed:9603190}.
uniprot
proteins
mass_dalton
225159
uniprot
proteins
post_translational_modification
PTM: May be ubiquitinated by NEDD4L; which would promote its endocytosis. {ECO:0000250|UniProtKB:Q9WTU3}.; PTM: Phosphorylation at Ser-1495 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents. {ECO:0000250}.
uniprot
proteins
protein_family
Nav1.6/SCN8A subfamily
uniprot
proteins
protein_family
Sodium channel (TC 1.A.1.10) family
uniprot
proteins
pubmed
15282281
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
24497506
uniprot
proteins
pubmed
9603190
uniprot
proteins
sequence_length
1978
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9603190}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UQD0}. Cell projection, axon {ECO:0000250|UniProtKB:Q9WTU3}. Note=Mainly localizes to the axon initial segment. {ECO:0000250|UniProtKB:Q9WTU3}.
uniprot
proteins
transmembrane_region
TRANSMEM 133..151; /note="Helical; Name=S1 of repeat I"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 159..179; /note="Helical; Name=S2 of repeat I"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 194..211; /note="Helical; Name=S3 of repeat I"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 218..234; /note="Helical; Name=S4 of repeat I"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 254..273; /note="Helical; Name=S5 of repeat I"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 388..408; /note="Helical; Name=S6 of repeat I"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 752..770; /note="Helical; Name=S1 of repeat II"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 782..801; /note="Helical; Name=S2 of repeat II"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 816..835; /note="Helical; Name=S3 of repeat II"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 838..855; /note="Helical; Name=S4 of repeat II"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 872..890; /note="Helical; Name=S5 of repeat II"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 954..974; /note="Helical; Name=S6 of repeat II"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 1198..1215; /note="Helical; Name=S1 of repeat III"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 1229..1247; /note="Helical; Name=S2 of repeat III"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 1262..1280; /note="Helical; Name=S3 of repeat III"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 1289..1307; /note="Helical; Name=S4 of repeat III"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 1325..1344; /note="Helical; Name=S5 of repeat III"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 1437..1458; /note="Helical; Name=S6 of repeat III"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 1522..1539; /note="Helical; Name=S1 of repeat IV"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 1551..1569; /note="Helical; Name=S2 of repeat IV"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 1582..1599; /note="Helical; Name=S3 of repeat IV"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 1613..1629; /note="Helical; Name=S4 of repeat IV"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 1649..1666; /note="Helical; Name=S5 of repeat IV"; /evidence="ECO:0000250|UniProtKB:D0E0C2"; TRANSMEM 1741..1763; /note="Helical; Name=S6 of repeat IV"; /evidence="ECO:0000250|UniProtKB:D0E0C2
uniprot
proteins