Cldn18
entrez
56492
canonical
uniprot
P56857
canonical
ensembl
ENSMUSG00000032473
resolver
ensp
ENSMUSP00000035048
resolver
ensp
ENSMUSP00000108503
resolver
ensp
ENSMUSP00000115782
resolver
ensp
ENSMUSP00000117382
resolver
genesymbol
Cldn18
resolver
uniprot
Q8BZS5
resolver
uniprot
Q91ZY9
resolver
uniprot
Q91ZZ0
resolver
uniprot
Q91ZZ1
resolver
uniprot_entry
CLD18_MOUSE
resolver
uniprot_entry
Q8BZS5_MOUSE
resolver
uniprot_sec
Q91ZY9
resolver
uniprot_sec
Q91ZZ0
resolver
uniprot_sec
Q91ZZ1
resolver
amino_acid_sequence
MATTTCQVVGLLLSLLGLAGCIAATGMDMWSTQDLYDNPVTAVFQYEGLWRSCVQQSSGFTECRPYFTILGLPAMLQAVRALMIVGIVLGVIGILVSIFALKCIRIGSMDDSAKAKMTLTSGILFIISGICAIIGVSVFANMLVTNFWMSTANMYSGMGGMGGMVQTVQTRYTFGAALFVGWVAGGLTLIGGVMMCIACRGLTPDDSNFKAVSYHASGQNVAYRPGGFKASTGFGSNTRNKKIYDGGARTEDDEQSHPTKYDYV
uniprot
proteins
function
FUNCTION: Involved in alveolar fluid homeostasis via regulation of alveolar epithelial tight junction composition and therefore ion transport and solute permeability, potentially via downstream regulation of the actin cytoskeleton organization and beta-2-adrenergic signaling (PubMed:24588076). Required for lung alveolarization and maintenance of the paracellular alveolar epithelial barrier (PubMed:24787463). Acts to maintain epithelial progenitor cell proliferation and organ size, via regulation of YAP1 localization away from the nucleus and thereby restriction of YAP1 target gene transcription (PubMed:29400695). Acts as a negative regulator of RANKL-induced osteoclast differentiation, potentially via relocation of TJP2/ZO-2 away from the nucleus, subsequently involved in bone resorption in response to calcium deficiency (PubMed:22437732). Mediates the osteoprotective effects of estrogen, potentially via acting downstream of estrogen signaling independently of RANKL signaling pathways (PubMed:23299504). {ECO:0000269|PubMed:22437732, ECO:0000269|PubMed:23299504, ECO:0000269|PubMed:24588076, ECO:0000269|PubMed:24787463, ECO:0000269|PubMed:29400695}.; FUNCTION: [Isoform A1.1]: Involved in the maintenance of homeostasis of the alveolar microenvironment via regulation of pH and subsequent T-cell activation in the alveolar space, is therefore indirectly involved in limiting C.neoformans infection. {ECO:0000269|PubMed:34702961}.; FUNCTION: [Isoform A2.1]: Required for the formation of the gastric paracellular barrier via its role in tight junction formation, thereby involved in the response to gastric acidification. {ECO:0000269|PubMed:22079592}.
uniprot
proteins
mass_dalton
28122
uniprot
proteins
protein_family
Claudin family
uniprot
proteins
pubmed
11585919
uniprot
proteins
pubmed
19706394
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22079592
uniprot
proteins
pubmed
22437732
uniprot
proteins
pubmed
23299504
uniprot
proteins
pubmed
24588076
uniprot
proteins
pubmed
24787463
uniprot
proteins
pubmed
29400695
uniprot
proteins
pubmed
34702961
uniprot
proteins
sequence_length
264
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000269|PubMed:11585919, ECO:0000269|PubMed:29400695}. Cell membrane {ECO:0000269|PubMed:11585919, ECO:0000269|PubMed:29400695}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to tight junctions in epithelial cells. {ECO:0000269|PubMed:11585919}.; SUBCELLULAR LOCATION: [Isoform A1.1]: Cell junction, tight junction {ECO:0000269|PubMed:22079592}.; SUBCELLULAR LOCATION: [Isoform A2.1]: Cell junction, tight junction {ECO:0000269|PubMed:22079592}. Lateral cell membrane {ECO:0000269|PubMed:22079592}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..27; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 81..101; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 123..143; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 177..197; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins