FRMD8
entrez
83786
canonical
uniprot
Q9BZ67
canonical
ensembl
ENSG00000126391
resolver
ensp
ENSP00000319726
resolver
ensp
ENSP00000348270
resolver
ensp
ENSP00000392111
resolver
genesymbol
FRMD8
resolver
hgnc
HGNC:25462
resolver
uniprot
A8K6L3
resolver
uniprot
B4E2P1
resolver
uniprot
Q86V56
resolver
uniprot
Q8NCB5
resolver
uniprot_entry
A8K6L3_HUMAN
resolver
uniprot_entry
FRMD8_HUMAN
resolver
uniprot_sec
B4E2P1
resolver
uniprot_sec
Q86V56
resolver
uniprot_sec
Q8NCB5
resolver
amino_acid_sequence
MDGTEGSAGQPGPAERSHRSSVSSVGARAADVLVYLADDTVVPLAVENLPSLSAHELHRAVREVLQLPDIALDVFALWLVSPLLEVQLKPKHQPYKLGRQWPELLLRFTSAPDDDVAMDEPFLQFRRNVFFPKRRELQIHDEEVLRLLYEEAKGNVLAARYPCDVEDCEALGALVCRVQLGPYQPGRPAACDLREKLDSFLPAHLCKRGQSLFAALRGRGARAGPGEQGLLNAYRQVQEVSSDGGCEAALGTHYRAYLLKCHELPFYGCAFFHGEVDKPAQGFLHRGGRKPVSVAISLEGVHVIDSREKHVLLGLRFQELSWDHTSPEEEEPILWLEFDGDSEGTPVNKLLKIYSKQAELMSSLIEYCIELSQAAEPAGPQDSATGSPSDPSSSLAPVQRPKLRRQGSVVSSRIQHLSTIDYVEDGKGIRRVKPKRTTSFFSRQLSLGQGSYTVVQPGDSLEQG
uniprot
proteins
function
FUNCTION: Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (PubMed:29897333, PubMed:29897336). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (PubMed:19572019). {ECO:0000269|PubMed:19572019, ECO:0000269|PubMed:29897333, ECO:0000269|PubMed:29897336}.
uniprot
proteins
mass_dalton
51218
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19572019
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29897333
uniprot
proteins
pubmed
29897336
uniprot
proteins
sequence_length
464
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:19572019, ECO:0000269|PubMed:29897333}. Cell membrane {ECO:0000269|PubMed:19572019, ECO:0000269|PubMed:29897333}.
uniprot
proteins