Rdh11
entrez
17252
canonical
uniprot
Q9QYF1
canonical
ensembl
ENSMUSG00000066441
resolver
ensp
ENSMUSP00000082352
resolver
ensp
ENSMUSP00000124066
resolver
enst
ENSMUST00000085254
resolver
enst
ENSMUST00000161204
resolver
genesymbol
Rdh11
resolver
genesymbol_syn
Arsdr1
resolver
genesymbol_syn
Mdt1
resolver
genesymbol_syn
Psdr1
resolver
genesymbol_syn
Ube-1b
resolver
uniprot
F8WJB3
resolver
uniprot
Q3UXM9
resolver
uniprot
Q9D0U5
resolver
uniprot
Q9R1R8
resolver
uniprot_entry
F8WJB3_MOUSE
resolver
uniprot_entry
Q9R1R8_MOUSE
resolver
uniprot_entry
RDH11_MOUSE
resolver
uniprot_sec
Q3UXM9
resolver
uniprot_sec
Q9D0U5
resolver
amino_acid_sequence
MFGFLLLLSLPFILYLVTPKIRKMLSSGVCTSNVQLPGKVAIVTGANTGIGKETAKDLAQRGARVYLACRDVDKGELAAREIQAVTGNSQVFVRKLDLADTKSIRAFAKDFLAEEKHLHLLINNAGVMMCPYSKTADGFEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNLSSLGHHLGRIHFHNLQGEKFYSAGLAYCHSKLANILFTKELAKRLKGSGVTTYSVHPGTVHSELTRYSSIMRWLWQLFFVFIKTPQEGAQTSLYCALTEGLESLSGSHFSDCQLAWVSYQGRNEIIARRLWDVSCDLLGLPVDW
uniprot
proteins
ec_number
1.1.1.300
uniprot
proteins
function
FUNCTION: Retinol dehydrogenase with a clear preference for NADP (PubMed:12807874, PubMed:29567832). Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol (By similarity) (PubMed:12807874). Also exhibits reductive activity towards toxic lipid peroxidation products such as medium-chain aldehydes trans-2-nonenal, nonanal, and cis-6-nonenal (PubMed:12807874). Has no dehydrogenase activity towards steroid (PubMed:12807874). Seems to be required for homeostasis of retinol in liver and testis (PubMed:29567832). {ECO:0000250|UniProtKB:Q8TC12, ECO:0000269|PubMed:12807874, ECO:0000269|PubMed:29567832}.
uniprot
proteins
mass_dalton
35148
uniprot
proteins
pathway_participation
PATHWAY: Cofactor metabolism; retinol metabolism. {ECO:0000269|PubMed:12807874}.
uniprot
proteins
post_translational_modification
PTM: Not glycosylated. {ECO:0000250|UniProtKB:Q8TC12}.
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
12137953
uniprot
proteins
pubmed
12807874
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15790565
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29567832
uniprot
proteins
pubmed
8018917
uniprot
proteins
sequence_length
316
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12807874}; Single-pass type II membrane protein {ECO:0000269|PubMed:12807874}.
uniprot
proteins
transmembrane_region
TRANSMEM 1..21; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000269|PubMed:12807874
uniprot
proteins