Rab27a
entrez
50645
canonical
uniprot
P23640
canonical
ensembl
ENSRNOG00000052499
resolver
ensembl
ENSRNOG00055007239
resolver
ensembl
ENSRNOG00060015877
resolver
ensembl
ENSRNOG00065017513
resolver
ensp
ENSRNOP00000068946
resolver
ensp
ENSRNOP00055009550
resolver
ensp
ENSRNOP00060021794
resolver
ensp
ENSRNOP00065023222
resolver
enst
ENSRNOT00000083957
resolver
enst
ENSRNOT00055012047
resolver
enst
ENSRNOT00060027180
resolver
enst
ENSRNOT00065029273
resolver
genesymbol
Rab27a
resolver
genesymbol_syn
Rab27
resolver
uniprot
Q4KMA7
resolver
uniprot_entry
RB27A_RAT
resolver
uniprot_sec
Q4KMA7
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) including DENND10, which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000250|UniProtKB:P51159}.
uniprot
proteins
amino_acid_sequence
MSDGDYDYLIKFLALGDSGVGKTSVLYQYTDGKFNSKFITTVGIDFREKRVVYRANGPDGTVGRGQRIHLQLWDTAGQERFRSLTTAFFRDAMGFLLLFDLTNEQSFLNVRNWISQLQMHAYCENPDIVLCGNKSDLEDQRAVKEEEARELAEKYGIPYFETSAANGTNISQAIEMLLDLIMKRMERCVDKSWIPEGVVRSNGHTSTDQLSEEKEKGLCGC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB27A regulates homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion. Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. {ECO:0000250|UniProtKB:P51159}.
uniprot
proteins
mass_dalton
25068
uniprot
proteins
mutagenesis
MUTAGEN 19; /note="G->V: No binding of GTP and GDP."; /evidence="ECO:0000269|PubMed:1527078"; MUTAGEN 41; /note="T->S: Increased rates of GTP binding and GDP dissociation."; /evidence="ECO:0000269|PubMed:1527078"; MUTAGEN 76; /note="A->T: Increased rates of GTP binding and GDP dissociation."; /evidence="ECO:0000269|PubMed:1527078"; MUTAGEN 78; /note="Q->L: Increased GTP dissociation and decreased GDP hydrolysis."; /evidence="ECO:0000269|PubMed:1527078"; MUTAGEN 133; /note="N->H: Increased rates of GTP binding and GDP dissociation."; /evidence="ECO:0000269|PubMed:1527078
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated in a FBXO28-dependent manner; leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q9ERI2}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
1527078
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2124544
uniprot
proteins
sequence_length
221
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P51159}; Lipid-anchor {ECO:0000250|UniProtKB:P51159}. Melanosome {ECO:0000250|UniProtKB:P51159}. Late endosome {ECO:0000250|UniProtKB:P51159}. Lysosome {ECO:0000250|UniProtKB:P51159}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes to endosomal exocytic vesicles. {ECO:0000250|UniProtKB:P51159}.
uniprot
proteins