AP1S3
entrez
130340
canonical
uniprot
Q96PC3
canonical
ensembl
ENSG00000152056
resolver
ensp
ENSP00000379891
resolver
ensp
ENSP00000573973
resolver
genesymbol
AP1S3
resolver
hgnc
HGNC:18971
resolver
uniprot
B4DQZ1
resolver
uniprot
Q8WTY1
resolver
uniprot
Q96DD1
resolver
uniprot_entry
AP1S3_HUMAN
resolver
uniprot_sec
B4DQZ1
resolver
uniprot_sec
Q8WTY1
resolver
uniprot_sec
Q96DD1
resolver
amino_acid_sequence
MIHFILLFSRQGKLRLQKWYITLPDKERKKITREIVQIILSRGHRTSSFVDWKELKLVYKRYASLYFCCAIENQDNELLTLEIVHRYVELLDKYFGNVCELDIIFNFEKAYFILDEFIIGGEIQETSKKIAVKAIEDSDMLQEVSTVSQTMGER
uniprot
proteins
disease_involvement
DISEASE: Psoriasis 15, pustular (PSORS15) [MIM:616106]: A form of pustular psoriasis, a life-threatening disease defined by repeated flares of sudden onset consisting of diffuse erythematous skin eruption characterized by rapid coverage with pustules, high-grade fever, asthenia, marked leukocytosis, and elevated serum levels of C-reactive protein. {ECO:0000269|PubMed:24791904}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes (PubMed:24791904, PubMed:36261523). The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (PubMed:24791904, PubMed:36261523). Involved in TLR3 trafficking (PubMed:24791904). {ECO:0000269|PubMed:24791904, ECO:0000269|PubMed:36261523}.
uniprot
proteins
mass_dalton
18280
uniprot
proteins
protein_family
Adaptor complexes small subunit family
uniprot
proteins
pubmed
11598180
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
24791904
uniprot
proteins
pubmed
36261523
uniprot
proteins
sequence_length
154
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
uniprot
proteins