Ncf1
entrez
17969
canonical
uniprot
Q09014
canonical
ensembl
ENSMUSG00000015950
resolver
ensp
ENSMUSP00000016094
resolver
ensp
ENSMUSP00000106906
resolver
ensp
ENSMUSP00000138121
resolver
enst
ENSMUST00000016094
resolver
enst
ENSMUST00000111275
resolver
enst
ENSMUST00000146354
resolver
genesymbol
Ncf1
resolver
uniprot
F8WH69
resolver
uniprot
O70144
resolver
uniprot
Q3UBI5
resolver
uniprot
Q3UE58
resolver
uniprot
Q9JI34
resolver
uniprot_entry
F8WH69_MOUSE
resolver
uniprot_entry
NCF1_MOUSE
resolver
uniprot_entry
Q3UBI5_MOUSE
resolver
uniprot_sec
O70144
resolver
uniprot_sec
Q3UE58
resolver
uniprot_sec
Q9JI34
resolver
amino_acid_sequence
MGDTFIRHIALLGFEKRFIPSQHYVYMFLVKWQDLSEKVVYRKFTEIYEFHKMLKEMFPIEAGEIHTENRVIPHLPAPRWFDGQRAAESRQGTLTEYFNGLMGLPVKISRCPHLLDFFKVRPDDLKLPTDSQAKKPETYLVPKDGKNNVADITGPIILQTYRAIADYEKSSGTEMTVATGDVVDVVEKSESGWWFCQMKTKRGWVPASYLEPLDSPDEAEDPDPNYAGEPYVTIKAYAAVEEDEMSLSEGEAIEVIHKLLDGWWVVRKGDITGYFPSMYLQKAGEEITQAQRQIRGRGAPPRRSTIRNAQSIHQRSRKRLSQDTYRRNSVRFLQQRRRPGRPGPLSTDGTKDNPSTPRVKPQPAVPPRPSSDLILHRCTESTKRKLTSAV
uniprot
proteins
function
FUNCTION: Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction. Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane. This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox. {ECO:0000250|UniProtKB:P14598}.
uniprot
proteins
mass_dalton
44667
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PRKCD; phosphorylation induces activation of NCF1, leading to assembly and activation of the NADPH oxidase complex. {ECO:0000269|PubMed:26021615}.
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16814099
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26021615
uniprot
proteins
pubmed
8119734
uniprot
proteins
pubmed
9490028
uniprot
proteins
sequence_length
390
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:26021615}. Membrane {ECO:0000269|PubMed:26021615}; Peripheral membrane protein {ECO:0000250|UniProtKB:P14598}; Cytoplasmic side {ECO:0000250|UniProtKB:P14598}.
uniprot
proteins