Pglyrp1
entrez
21946
canonical
uniprot
O88593
canonical
ensembl
ENSMUSG00000030413
resolver
ensp
ENSMUSP00000032573
resolver
enst
ENSMUST00000032573
resolver
genesymbol
Pglyrp1
resolver
genesymbol_syn
Pglyrp
resolver
genesymbol_syn
Pgrp
resolver
genesymbol_syn
Pgrps
resolver
genesymbol_syn
Tag7
resolver
uniprot
Q4FK86
resolver
uniprot
Q62185
resolver
uniprot_entry
PGRP1_MOUSE
resolver
uniprot_entry
Q4FK86_MOUSE
resolver
uniprot_sec
Q62185
resolver
amino_acid_sequence
MLFACALLALLGLATSCSFIVPRSEWRALPSECSSRLGHPVRYVVISHTAGSFCNSPDSCEQQARNVQHYHKNELGWCDVAYNFLIGEDGHVYEGRGWNIKGDHTGPIWNPMSIGITFMGNFMDRVPAKRALRAALNLLECGVSRGFLRSNYEVKGHRDVQSTLSPGDQLYQVIQSWEHYRE
uniprot
proteins
function
FUNCTION: Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. Acts as a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria and thus provides bactericidal activity (PubMed:12649138, PubMed:9660837, PubMed:9707603). Forms an equimolar complex with heat shock protein HSPA1A and induces programmed cell death through apoptosis and necroptosis in tumor cell lines by activating the TNFR1 receptor on the target cell membrane (PubMed:14585845). In addition, acts in complex with the Ca(2+)-binding protein S100A4 as a chemoattractant able to induce lymphocyte movement. Mechanistically, this complex acts as a ligand of the chemotactic receptors CCR5 and CXCR3 which are present on the cells of the immune system. Also promotes the activation of lymphocytes that become able to kill virus-infected cells as well as tumor cells by modulating the spectrum of their target-cell specificity. Induction of cytotoxicity on monocyte surface requires interaction with TREM1 receptor (By similarity). {ECO:0000250|UniProtKB:O75594, ECO:0000269|PubMed:12649138, ECO:0000269|PubMed:14585845, ECO:0000269|PubMed:9660837, ECO:0000269|PubMed:9707603}.
uniprot
proteins
mass_dalton
20489
uniprot
proteins
protein_family
N-acetylmuramoyl-L-alanine amidase 2 family
uniprot
proteins
pubmed
12649138
uniprot
proteins
pubmed
14585845
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9660837
uniprot
proteins
pubmed
9707603
uniprot
proteins
sequence_length
182
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9660837}. Secreted {ECO:0000269|PubMed:14585845, ECO:0000269|PubMed:9660837}. Note=Exists in both soluble and membrane-associated forms.
uniprot
proteins