P2rx3
entrez
228139
canonical
uniprot
Q3UR32
canonical
ensembl
ENSMUSG00000027071
resolver
ensp
ENSMUSP00000028465
resolver
enst
ENSMUST00000028465
resolver
genesymbol
P2rx3
resolver
uniprot
A2AW02
resolver
uniprot
Q8R1U4
resolver
uniprot_entry
P2RX3_MOUSE
resolver
uniprot_sec
A2AW02
resolver
uniprot_sec
Q8R1U4
resolver
activity_regulation
ACTIVITY REGULATION: Has high sensitivity to ATP. Fast activation by external ATP. Exhibits rapid desensitization. Sensitives to the ATP agonist:alpha/beta-methylene-ATP. Subject to allosteric inhibition by AF-219. Mg(2+) and Ca(2+) slow deactivation of P2RX3. {ECO:0000250|UniProtKB:P56373}.
uniprot
proteins
amino_acid_sequence
MNCISDFFTYETTKSVVVKSWTIGIINRAVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGFGRYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPENEEKYRCVSDSQCGPERFPGGGILTGRCVNYSSVRRTCEIQGWCPTEVDTVEMPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTDKDIKKCRFHPEKAPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDGVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADHYKARKFEEVTETTLKGTASTNPVFTSDQATVEKQSTDSGAYSIGH
uniprot
proteins
function
FUNCTION: Extracellular ATP-activated non-selective cation channel (By similarity). Plays particularly important role in sensory neurons where its activation is critical for gustatory, nociceptive responses, visceral reflexes and sensory hypersensitization (PubMed:11069181, PubMed:11466438, PubMed:15961431, PubMed:16322458). {ECO:0000250|UniProtKB:P56373, ECO:0000269|PubMed:11069181, ECO:0000269|PubMed:11466438, ECO:0000269|PubMed:15961431, ECO:0000269|PubMed:16322458}.
uniprot
proteins
mass_dalton
44437
uniprot
proteins
protein_family
P2X receptor family
uniprot
proteins
pubmed
11069181
uniprot
proteins
pubmed
11466438
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15961431
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16322458
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
397
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P56373}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P56373}. Note=Localizes to neuronal cell body of sensory neurons. {ECO:0000250|UniProtKB:P49654}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..43; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P56373"; TRANSMEM 323..341; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P56373
uniprot
proteins