TANK
entrez
10010
canonical
uniprot
Q92844
canonical
ensembl
ENSG00000136560
resolver
ensp
ENSP00000259075
resolver
ensp
ENSP00000376505
resolver
ensp
ENSP00000385983
resolver
ensp
ENSP00000552772
resolver
genesymbol
TANK
resolver
genesymbol_syn
ITRAF
resolver
genesymbol_syn
TRAF2
resolver
hgnc
HGNC:11562
resolver
uniprot
B2R7S3
resolver
uniprot
D3DPB5
resolver
uniprot
Q6NW12
resolver
uniprot
Q7Z4J6
resolver
uniprot
Q92885
resolver
uniprot_entry
B2R7S3_HUMAN
resolver
uniprot_entry
Q6NW12_HUMAN
resolver
uniprot_entry
TANK_HUMAN
resolver
uniprot_sec
D3DPB5
resolver
uniprot_sec
Q7Z4J6
resolver
uniprot_sec
Q92885
resolver
amino_acid_sequence
MDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKTENYEQRIREQQEQLSLQQTIIDKLKSQLLLVNSTQDNNYGCVPLLEDSETRKNNLTLDQPQDKVISGIAREKLPKVRRQEVSSPRKETSARSLGSPLLHERGNIEKTFWDLKEEFHKICMLAKAQKDHLSKLNIPDTATETQCSVPIQCTDKTDKQEALFKPQAKDDINRGAPSITSVTPRGLCRDEEDTSFESLSKFNVKFPPMDNDSTFLHSTPERPGILSPATSEAVCQEKFNMEFRDNPGNFVKTEETLFEIQGIDPIASAIQNLKTTDKTKPSNLVNTCIRTTLDRAACLPPGDHNALYVNSFPLLDPSDAPFPSLDSPGKAIRGPQQPIWKPFPNQDSDSVVLSGTDSELHIPRVCEFCQAVFPPSITSRGDFLRHLNSHFNGET
uniprot
proteins
function
FUNCTION: Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. {ECO:0000269|PubMed:12133833, ECO:0000269|PubMed:21931631, ECO:0000269|PubMed:25861989}.
uniprot
proteins
mass_dalton
47816
uniprot
proteins
mutagenesis
MUTAGEN 182; /note="Q->A: Abolishes interaction with TRAF2 and TRAF3."; /evidence="ECO:0000269|PubMed:12005438"; MUTAGEN 184; /note="T->A: Abolishes interaction with TRAF2 and TRAF3."; /evidence="ECO:0000269|PubMed:12005438"; MUTAGEN 185; /note="D->A: Abolishes interaction with TRAF2; greatly diminishes interaction with TRAF3."; /evidence="ECO:0000269|PubMed:12005438"; MUTAGEN 188; /note="D->A: Diminishes interaction with TRAF2 and TRAF3."; /evidence="ECO:0000269|PubMed:12005438"; MUTAGEN 194; /note="F->A: Diminishes interaction with TRAF2 and TRAF3."; /evidence="ECO:0000269|PubMed:12005438"; MUTAGEN 197; /note="Q->A: No effect on cleavage by Seneca Valley virus protease 3C."; /evidence="ECO:0000269|PubMed:28566380"; MUTAGEN 247; /note="H->A: No effect on cleavage by Seneca Valley virus protease 3C."; /evidence="ECO:0000269|PubMed:28566380"; MUTAGEN 251; /note="E->A: No effect on cleavage by Seneca Valley virus protease 3C."; /evidence="ECO:0000269|PubMed:28566380"; MUTAGEN 262; /note="E->A: No effect on cleavage by Seneca Valley virus protease 3C."; /evidence="ECO:0000269|PubMed:28566380"; MUTAGEN 266; /note="Q->A: No effect on cleavage by Seneca Valley virus protease 3C."; /evidence="ECO:0000269|PubMed:28566380"; MUTAGEN 267; /note="E->A: No effect on cleavage by Seneca Valley virus protease 3C."; /evidence="ECO:0000269|PubMed:28566380"; MUTAGEN 272; /note="E->A: Complete loss of cleavage by Seneca Valley virus protease 3C."; /evidence="ECO:0000269|PubMed:28566380"; MUTAGEN 291; /note="Q->A: Complete loss of cleavage by Seneca Valley virus protease 3C."; /evidence="ECO:0000269|PubMed:28566380
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by IKBKE. {ECO:0000269|PubMed:10759890}.; PTM: (Microbial infection) Cleaved by encephalomyocarditis virus (EMCV) protease 3C (PubMed:26363073). This cleavage allows the virus to disrupt the TANK-TBK1-IKKepsilon-IRF3 complex, thereby inhibiting the induction of the IFN-beta signal pathway (PubMed:28487378). {ECO:0000269|PubMed:26363073, ECO:0000269|PubMed:28487378}.; PTM: (Microbial infection) Cleaved by Seneca Valley virus protease 3C allowing the virus to suppress interferon type-I through both RIG-I and Toll-like receptor-dependent pathways. {ECO:0000269|PubMed:28566380}.
uniprot
proteins
pubmed
10581243
uniprot
proteins
pubmed
10759890
uniprot
proteins
pubmed
12005438
uniprot
proteins
pubmed
12133833
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17568778
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21931555
uniprot
proteins
pubmed
21931631
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25861989
uniprot
proteins
pubmed
26363073
uniprot
proteins
pubmed
28487378
uniprot
proteins
pubmed
28566380
uniprot
proteins
pubmed
29251827
uniprot
proteins
pubmed
8710854
uniprot
proteins
pubmed
8855313
uniprot
proteins
sequence_length
425
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins