ACOD1
entrez
730249
canonical
uniprot
A6NK06
canonical
ensembl
ENSG00000102794
resolver
ensp
ENSP00000366682
resolver
enst
ENST00000377462
resolver
genesymbol
ACOD1
resolver
genesymbol_syn
IRG1
resolver
hgnc
HGNC:33904
resolver
uniprot_entry
IRG1_HUMAN
resolver
amino_acid_sequence
MMLKSITESFATAIHGLKVGHLTDRVIQRSKRMILDTLGAGFLGTTTEVFHIASQYSKIYSSNISSTVWGQPDIRLPPTYAAFVNGVAIHSMDFDDTWHPATHPSGAVLPVLTALAEALPRSPKFSGLDLLLAFNVGIEVQGRLLHFAKEANDMPKRFHPPSVVGTLGSAAAASKFLGLSSTKCREALAIAVSHAGAPMANAATQTKPLHIGNAAKHGIEAAFLAMLGLQGNKQVLDLEAGFGAFYANYSPKVLPSIASYSWLLDQQDVAFKRFPAHLSTHWVADAAASVRKHLVAERALLPTDYIKRIVLRIPNVQYVNRPFPVSEHEARHSFQYVACAMLLDGGITVPSFHECQINRPQVRELLSKVELEYPPDNLPSFNILYCEISVTLKDGATFTDRSDTFYGHWRKPLSQEDLEEKFRANASKMLSWDTVESLIKIVKNLEDLEDCSVLTTLLKGPSPPEVASNSPACNNSITNLS
uniprot
proteins
ec_number
4.1.1.6
uniprot
proteins
function
FUNCTION: Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response (PubMed:23609450, PubMed:23610393, PubMed:31548418, PubMed:35662396). Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages (PubMed:23609450). Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the antimicrobial activity of macrophages by generating itaconate, leading to alkylation of proteins, such as TFEB (PubMed:23610393, PubMed:35662396). Involved in antiviral response following infection by flavivirus in neurons: ACOD1-mediated itaconate production inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity). Plays a role in the embryo implantation (By similarity). {ECO:0000250|UniProtKB:P54987, ECO:0000269|PubMed:23609450, ECO:0000269|PubMed:23610393, ECO:0000269|PubMed:31548418, ECO:0000269|PubMed:35662396}.
uniprot
proteins
mass_dalton
52628
uniprot
proteins
mutagenesis
MUTAGEN 93; /note="D->A: Abolished cis-aconitate decarboxylase activity."; /evidence="ECO:0000269|PubMed:31548418"; MUTAGEN 97; /note="T->A: Strongly reduced cis-aconitate decarboxylase activity."; /evidence="ECO:0000269|PubMed:31548418"; MUTAGEN 103; /note="H->A: Abolished cis-aconitate decarboxylase activity."; /evidence="ECO:0000269|PubMed:31548418"; MUTAGEN 159; /note="H->A: Abolished cis-aconitate decarboxylase activity."; /evidence="ECO:0000269|PubMed:31548418"; MUTAGEN 207; /note="K->A: Abolished cis-aconitate decarboxylase activity."; /evidence="ECO:0000269|PubMed:31548418"; MUTAGEN 272; /note="K->A: Abolished cis-aconitate decarboxylase activity."; /evidence="ECO:0000269|PubMed:31548418"; MUTAGEN 277; /note="H->A: Abolished cis-aconitate decarboxylase activity."; /evidence="ECO:0000269|PubMed:31548418"; MUTAGEN 318; /note="Y->A: Abolished cis-aconitate decarboxylase activity."; /evidence="ECO:0000269|PubMed:31548418
uniprot
proteins
protein_family
PrpD family
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
23609450
uniprot
proteins
pubmed
23610393
uniprot
proteins
pubmed
31548418
uniprot
proteins
pubmed
35662396
uniprot
proteins
sequence_length
481
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P54987}.
uniprot
proteins