IL1R2
entrez
7850
canonical
uniprot
P27930
canonical
ensembl
ENSG00000115590
resolver
ensp
ENSP00000330959
resolver
ensp
ENSP00000414611
resolver
ensp
ENSP00000579882
resolver
ensp
ENSP00000693653
resolver
genesymbol
IL1R2
resolver
genesymbol_syn
IL1RB
resolver
hgnc
HGNC:5994
resolver
uniprot
D3DVJ5
resolver
uniprot
Q6LCE6
resolver
uniprot
Q9UE68
resolver
uniprot_entry
IL1R2_HUMAN
resolver
uniprot_sec
D3DVJ5
resolver
uniprot_sec
Q6LCE6
resolver
uniprot_sec
Q9UE68
resolver
amino_acid_sequence
MLRLYVLVMGVSAFTLQPAAHTGAARSCRFRGRHYKREFRLEGEPVALRCPQVPYWLWASVSPRINLTWHKNDSARTVPGEEETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFLPFISYPQILTLSTSGVLVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTHLLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETIPVIISPLKTISASLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPGGRVTEGPRQEYSENNENYIEVPLIFDPVTREDLHMDFKCVVHNTLSFQTLRTTVKEASSTFSWGIVLAPLSLAFLVLGGIWMHRRCKHRTGKADGLTVLWPHHQDFQSYPK
uniprot
proteins
function
FUNCTION: Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. {ECO:0000269|PubMed:10975853, ECO:0000269|PubMed:12530978, ECO:0000269|PubMed:7989776, ECO:0000269|PubMed:9862719}.
uniprot
proteins
mass_dalton
45421
uniprot
proteins
post_translational_modification
PTM: A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase; hovever, several sIL1R2 forms ranging from 45 and 60 kDa are reported. {ECO:0000269|PubMed:7989776, ECO:0000269|PubMed:9395521}.
uniprot
proteins
protein_family
Interleukin-1 receptor family
uniprot
proteins
pubmed
10975853
uniprot
proteins
pubmed
12530978
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
1833184
uniprot
proteins
pubmed
20802483
uniprot
proteins
pubmed
7878046
uniprot
proteins
pubmed
7989776
uniprot
proteins
pubmed
8702856
uniprot
proteins
pubmed
9395521
uniprot
proteins
pubmed
9862719
uniprot
proteins
sequence_length
398
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform Short]: Secreted {ECO:0000269|PubMed:8702856}.; SUBCELLULAR LOCATION: [Isoform Long]: Cell membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 344..369; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins