HNRNPA1
entrez
3178
canonical
uniprot
P09651
canonical
ensembl
ENSG00000135486
resolver
ensp
ENSP00000341826
resolver
ensp
ENSP00000448617
resolver
genesymbol
HNRNPA1
resolver
genesymbol_syn
HNRPA1
resolver
hgnc
HGNC:5031
resolver
uniprot
A0A024RB53
resolver
uniprot
A8K4Z8
resolver
uniprot
Q3MIB7
resolver
uniprot
Q6PJZ7
resolver
uniprot_entry
A0A024RB53_HUMAN
resolver
uniprot_entry
ROA1_HUMAN
resolver
uniprot_sec
A8K4Z8
resolver
uniprot_sec
Q3MIB7
resolver
uniprot_sec
Q6PJZ7
resolver
amino_acid_sequence
MSKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYGGSGDGYNGFGNDGGYGGGGPGYSGGSRGYGSGGQGYGNQGSGYGGSGSYDSYNNGGGGGFGGGSGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGYGGSSSSSSYGSGRRF
uniprot
proteins
disease_involvement
DISEASE: Inclusion body myopathy with early-onset Paget disease with or without frontotemporal dementia 3 (IBMPFD3) [MIM:615424]: An autosomal dominant disease characterized by disabling muscle weakness clinically resembling to limb girdle muscular dystrophy, osteolytic bone lesions consistent with Paget disease, and premature frontotemporal dementia. Clinical features show incomplete penetrance. {ECO:0000269|PubMed:23455423, ECO:0000269|PubMed:25616961}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Amyotrophic lateral sclerosis 20 (ALS20) [MIM:615426]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. {ECO:0000269|PubMed:23455423, ECO:0000269|PubMed:27694260}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Myopathy, distal, 3 (MPD3) [MIM:610099]: An autosomal dominant skeletal muscle disorder characterized by adult onset of slowly progressive distal muscular weakness and atrophy affecting the upper and lower limbs, leading to difficulties using the hands and walking difficulties. Proximal muscle involvement may occur later in the disease, but patients typically remain ambulatory. Muscle biopsy shows myopathic changes with rimmed vacuoles. {ECO:0000269|PubMed:34722876}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and modulation of splice site selection (PubMed:17371836). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 (PubMed:31498791). May bind to specific miRNA hairpins (PubMed:28431233). {ECO:0000269|PubMed:17371836, ECO:0000269|PubMed:20010808, ECO:0000269|PubMed:28431233, ECO:0000269|PubMed:31498791}.; FUNCTION: (Microbial infection) May play a role in HCV RNA replication. {ECO:0000269|PubMed:17229681}.; FUNCTION: (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis. {ECO:0000269|PubMed:17229681}.
uniprot
proteins
mass_dalton
38747
uniprot
proteins
mutagenesis
MUTAGEN 218; /note="R->A: Abolishes interaction with HOXB-AS3 peptide; when associated with A-225 and A-232."; /evidence="ECO:0000269|PubMed:28985503"; MUTAGEN 225; /note="R->A: Abolishes interaction with HOXB-AS3 peptide; when associated with A-218 and A-232."; /evidence="ECO:0000269|PubMed:28985503"; MUTAGEN 232; /note="R->A: Abolishes interaction with HOXB-AS3 peptide; when associated with A-218 and A-225."; /evidence="ECO:0000269|PubMed:28985503"; MUTAGEN 326; /note="G->A: No nuclear import nor export."; /evidence="ECO:0000269|PubMed:7730395"; MUTAGEN 327; /note="P->A: No nuclear import nor export."; /evidence="ECO:0000269|PubMed:7730395"; MUTAGEN 334..335; /note="GG->LL: Normal nuclear import and export."; /evidence="ECO:0000269|PubMed:7730395
uniprot
proteins
post_translational_modification
PTM: Arg-194, Arg-206 and Arg-225 are dimethylated, probably to asymmetric dimethylarginine.; PTM: Sumoylated. {ECO:0000269|PubMed:15161980}.
uniprot
proteins
pubmed
11991638
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15161980
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15782174
uniprot
proteins
pubmed
15862300
uniprot
proteins
pubmed
16111636
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
1691095
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17229681
uniprot
proteins
pubmed
17289661
uniprot
proteins
pubmed
17371836
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20010808
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
2176620
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23455423
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24549040
uniprot
proteins
pubmed
25616961
uniprot
proteins
pubmed
25678563
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
2760922
uniprot
proteins
pubmed
27694260
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
2836799
uniprot
proteins
pubmed
28431233
uniprot
proteins
pubmed
28985503
uniprot
proteins
pubmed
3023065
uniprot
proteins
pubmed
31498791
uniprot
proteins
pubmed
33360543
uniprot
proteins
pubmed
34722876
uniprot
proteins
pubmed
7730395
uniprot
proteins
pubmed
7769000
uniprot
proteins
pubmed
8521471
uniprot
proteins
pubmed
9115444
uniprot
proteins
pubmed
9164463
uniprot
proteins
sequence_length
372
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:27694260}. Cytoplasm {ECO:0000269|PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles continuously between the nucleus and the cytoplasm along with mRNA. Component of ribonucleosomes (PubMed:17289661). {ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:27694260}.; SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17229681}. Note=(Microbial infection) In the course of viral infection, colocalizes with HCV NS5B at speckles in the cytoplasm in a HCV-replication dependent manner. {ECO:0000269|PubMed:17229681}.; SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:33360543}. Note=(Microbial infection) SARS coronavirus-2/SARS-CoV-2 ORF6 protein increases accumulation to the nucleus. {ECO:0000269|PubMed:33360543}.
uniprot
proteins