Pawr
entrez
64513
canonical
uniprot
Q62627
canonical
ensembl
ENSRNOG00000005917
resolver
ensp
ENSRNOP00000085170
resolver
ensp
ENSRNOP00000107478
resolver
enst
ENSRNOT00000113713
resolver
genesymbol
Pawr
resolver
genesymbol_syn
Par4
resolver
uniprot
A0A8I6A135
resolver
uniprot_entry
A0A8I6A135_RAT
resolver
uniprot_entry
PAWR_RAT
resolver
amino_acid_sequence
MATGGYRSSGSTTDFLEEWKAKREKMRAKQNPVGPGSSGGDPAAKSPAGPLAQTTAAGTSELNHGPAGAAAPAAPGPGALNCAHGSSALPRGAPGSRRPEDECPIAAGAAGAPASRGDEEEPDSAPEKGRSSGPSARKGKGQIEKRKLREKRRSTGVVNIPAAECLDEYEDDEAGQKERKREDAITQQNTIQNEAASLPDPGTSYLPQDPSRTVPGRYKSTISAPEEEILNRYPRTDRSGFSRHNRDTSAPANFASSSTLEKRIEDLEKEVLRERQENLRLTRLMQDKEEMIGKLKEEIDLLNRDLDDMEDENEQLKQENKTLLKVVGQLTR
uniprot
proteins
function
FUNCTION: Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Also seems to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1 (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
35866
uniprot
proteins
post_translational_modification
PTM: Preferentially phosphorylated at the Thr-155 by PKC in cancer cells. {ECO:0000269|PubMed:15657440}.
uniprot
proteins
pubmed
12897127
uniprot
proteins
pubmed
15657440
uniprot
proteins
pubmed
15817164
uniprot
proteins
pubmed
8043520
uniprot
proteins
sequence_length
332
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis. Nuclear localization includes nucleoplasm and PML nuclear bodies (By similarity). {ECO:0000250}.
uniprot
proteins