Dgka
entrez
140866
canonical
uniprot
P51556
canonical
ensembl
ENSRNOG00000022943
resolver
ensembl
ENSRNOG00055014353
resolver
ensembl
ENSRNOG00060027146
resolver
ensembl
ENSRNOG00065012992
resolver
ensp
ENSRNOP00000038628
resolver
ensp
ENSRNOP00000080029
resolver
ensp
ENSRNOP00055020126
resolver
ensp
ENSRNOP00060039222
resolver
ensp
ENSRNOP00065016434
resolver
enst
ENSRNOT00000036373
resolver
enst
ENSRNOT00000102609
resolver
enst
ENSRNOT00055024643
resolver
enst
ENSRNOT00060047150
resolver
enst
ENSRNOT00065021274
resolver
genesymbol
Dgka
resolver
genesymbol_syn
Dagk
resolver
genesymbol_syn
Dagk1
resolver
uniprot
A0A8I6G415
resolver
uniprot
A0A8L2QJB9
resolver
uniprot_entry
A0A8I6G415_RAT
resolver
uniprot_entry
A0A8L2QJB9_RAT
resolver
uniprot_entry
DGKA_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Stimulated by calcium and phosphatidylserine (By similarity). Activated by sphingosine (PubMed:22627129). {ECO:0000250|UniProtKB:P23743, ECO:0000269|PubMed:22627129}.
uniprot
proteins
amino_acid_sequence
MAKDKGLISPEDFAQLQKYIDYSTKSVSDVLKVFEMNKYCQGDEIGYLGFEQFLKMYLEVEEVPHHLCWTLFWSFHSSQDLDEETESKANVICLSDVYCYFTLLEGGSPEDKLEFTFKLYDMDRNGILDSTEVEKIILQMMRVAEYLDWDVSELRPILQEMMKEMDRDGSGCVSLAEWVRAGATTVPLLVLLGIDMTMKDDGHHIWRPKRFSRPVYCNLCELSIGLGKQGLSCNLCKYIVHDHCAMKAQPCEVSTYAKSRKDIGVQPHVWVRGGCHSGRCDRCQKKIRTYHSLTGLHCVWCHLEIHDDCLQAVGPECDCGLLRDHILPPCSIYPRVLVSGQECKQKTTDVTSLCTPEAFRIEPVSNTHPLLVFINPKSGGKQGQSVLWKFQYILNPRQVFNLKDGPEPGLRFFKDVPQFRVLVCGGDGTVGWILETIDKANFPIVPPVAVLPLGTGNDLARCLRWGRGYEGENLRKILKDIEISKVVYLDRWLLEVIPQQNGEKSDPVPSQIINNYFSIGVDASIAHRFHLMREKYPEKFNSRMKNKLWYLEFATSESIFSTCKKLEESVTVEICGKLLDLSDLSLEGIAVLNIPSMHGGSNLWGDTKRPHGDTCGINQALGSVAKIITDPDILKTCVPDMSDKRLEVVGIEGVIEMGQIYTRLKSAGHRLAKCSEITFQTTKTLPMQVDGEPWMQAPCTIKITHKNQMPMLMGPAPSSSNFFGFWS
uniprot
proteins
ec_number
2.7.1.107
uniprot
proteins
ec_number
2.7.1.93
uniprot
proteins
function
FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:22627129). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:22627129). Also plays an important role in the biosynthesis of complex lipids. Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently as diacylglycerol provided it contains an arachidonoyl group (By similarity). Also involved in the production of alkyl-lysophosphatidic acid, another bioactive lipid, through the phosphorylation of 1-alkyl-2-acetyl glycerol (PubMed:22627129). {ECO:0000250|UniProtKB:P23743, ECO:0000269|PubMed:22627129}.
uniprot
proteins
mass_dalton
82199
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; glycerolipid metabolism. {ECO:0000305|PubMed:22627129}.
uniprot
proteins
protein_family
Eukaryotic diacylglycerol kinase family
uniprot
proteins
pubmed
1339302
uniprot
proteins
pubmed
22627129
uniprot
proteins
sequence_length
727
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:22627129}.
uniprot
proteins