Pitx2
entrez
18741
canonical
uniprot
P97474
canonical
ensembl
ENSMUSG00000028023
resolver
ensp
ENSMUSP00000047359
resolver
ensp
ENSMUSP00000101990
resolver
ensp
ENSMUSP00000133756
resolver
ensp
ENSMUSP00000134692
resolver
genesymbol
Pitx2
resolver
genesymbol_syn
Arp1
resolver
genesymbol_syn
Brx1
resolver
genesymbol_syn
Otlx2
resolver
genesymbol_syn
Ptx2
resolver
genesymbol_syn
Rgs
resolver
genesymbol_syn
Rieg
resolver
uniprot
B1VD84
resolver
uniprot
B1VD85
resolver
uniprot
O08646
resolver
uniprot
O70336
resolver
uniprot
P97933
resolver
uniprot
Q6DIA6
resolver
uniprot
Q9JLA0
resolver
uniprot
Q9QXB8
resolver
uniprot
Q9R1V9
resolver
uniprot
Q9Z141
resolver
uniprot_entry
B1VD84_MOUSE
resolver
uniprot_entry
B1VD85_MOUSE
resolver
uniprot_entry
PITX2_MOUSE
resolver
uniprot_entry
Q6DIA6_MOUSE
resolver
uniprot_sec
O08646
resolver
uniprot_sec
O70336
resolver
uniprot_sec
P97933
resolver
uniprot_sec
Q9JLA0
resolver
uniprot_sec
Q9QXB8
resolver
uniprot_sec
Q9R1V9
resolver
uniprot_sec
Q9Z141
resolver
amino_acid_sequence
METNCRKLVSACVQLGVQPAAVECLFSKDSEIKKVEFTDSPKSRKESASSKLFPRQHPGANEKDKGQQGKNEDVGAEDPSKKKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGFGPQFNGLMQPYDDMYPGYSYNNWAAKGLTSASLSTKSFPFFNSMNVNPLSSQSMFSPPNSISSMSMSSSMVPSAVTGVPGSSLNSLNNLNNLSSPSLNSAVPTPACPYAPPTPPYVYRDTCNSSLASLRLKAKQHSSFGYASVQNPASNLSACQYAVDRPV
uniprot
proteins
function
FUNCTION: May play a role in myoblast differentiation. When unphosphorylated, associates with an ELAVL1-containing complex, which stabilizes cyclin mRNA and ensuring cell proliferation. Phosphorylation by AKT2 impairs this association, leading to CCND1 mRNA destabilization and progression towards differentiation. {ECO:0000269|PubMed:20019746}.; FUNCTION: [Isoform Ptx2c]: Involved in the establishment of left-right asymmetry in the developing embryo. {ECO:0000269|PubMed:10585561}.
uniprot
proteins
mass_dalton
35321
uniprot
proteins
mutagenesis
MUTAGEN 90; /note="T->A: Loss of phosphorylation by AKT2."; /evidence="ECO:0000269|PubMed:20019746
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Thr-90 by AKT2, but not AKT1. Phosphorylation impairs its association with a CCND1 mRNA-stabilizing complex, thus shortening the half-life of CCND1. {ECO:0000269|PubMed:20019746}.
uniprot
proteins
protein_family
Bicoid subfamily
uniprot
proteins
protein_family
Paired homeobox family
uniprot
proteins
pubmed
10585561
uniprot
proteins
pubmed
11319841
uniprot
proteins
pubmed
15475956
uniprot
proteins
pubmed
20019746
uniprot
proteins
pubmed
8944018
uniprot
proteins
pubmed
9147650
uniprot
proteins
pubmed
9347917
uniprot
proteins
pubmed
9539779
uniprot
proteins
sequence_length
317
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:20019746}.
uniprot
proteins