Spata2
entrez
114210
canonical
uniprot
Q66HP6
canonical
ensembl
ENSRNOG00000009207
resolver
ensembl
ENSRNOG00065018999
resolver
ensp
ENSRNOP00000012604
resolver
ensp
ENSRNOP00065025500
resolver
enst
ENSRNOT00065031946
resolver
genesymbol
Spata2
resolver
genesymbol_syn
Pd1
resolver
uniprot
F1LNA7
resolver
uniprot
Q91XS7
resolver
uniprot_entry
SPAT2_RAT
resolver
uniprot_sec
F1LNA7
resolver
uniprot_sec
Q91XS7
resolver
amino_acid_sequence
MDTKYKDDLFRKYVQFHEGKVDTTPGKQSGSDEYLRVAAATLLSLHKVDPLYRFRLIQFYEVVESSLRSLSSSSLSALHCAFSMLETMAINLFLFPWKKEFRSIKTYTGPFVYYVKSTLLEKDIRAILKFMGYEPELGTAYKLKELVESLQVKMVSFELFLAKVECEQMLGIHSQVKDKGYSELDVVTERKSSTEDARGCSDALRRRAESREHLTTSMARVALQKSASERAAKDYYKPRVTKPSRSVDAYDSYWESRKPPSKASLSLRKEPLAMDVGEDLKDEIIRPSPSLLTMSSSPHGSPDDLPSISPINGLGLLRSTYFPTQDDVDLYTDSEPRATYRRQDALRSDIWLVKNDAHSIYHKRSPPTKESALSKCQNCGLSCSSSLCQRCDSVCPSASKPSGFPSKASAHDSLVHGAPMREKYVGQTQGLDRLATVHSKPKPSTTATSRCGFCNRAGATNTCTQCSKVSCDPCLGAYHYDPCCRKSELHKFMPNNQLNYKSTQFSHPVYR
uniprot
proteins
function
FUNCTION: Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-induced necroptosis. Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC). Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD (By similarity). Controls the kinase activity of RIPK1 and TNF-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD (By similarity). {ECO:0000250|UniProtKB:Q8K004, ECO:0000250|UniProtKB:Q9UM82}.
uniprot
proteins
mass_dalton
57481
uniprot
proteins
protein_family
SPATA2 family
uniprot
proteins
pubmed
11079456
uniprot
proteins
pubmed
11322771
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
511
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UM82}. Nucleus {ECO:0000269|PubMed:11322771}.
uniprot
proteins