Mbtd1
entrez
103537
canonical
uniprot
Q6P5G3
canonical
ensembl
ENSMUSG00000059474
resolver
ensp
ENSMUSP00000065442
resolver
ensp
ENSMUSP00000103485
resolver
ensp
ENSMUSP00000103486
resolver
ensp
ENSMUSP00000269207
resolver
ensp
ENSMUSP00000269208
resolver
ensp
ENSMUSP00000269210
resolver
ensp
ENSMUSP00000269217
resolver
ensp
ENSMUSP00000269219
resolver
ensp
ENSMUSP00000339297
resolver
ensp
ENSMUSP00000339302
resolver
ensp
ENSMUSP00000339306
resolver
genesymbol
Mbtd1
resolver
uniprot
Q6P3F0
resolver
uniprot
Q8VE12
resolver
uniprot_entry
MBTD1_MOUSE
resolver
uniprot_sec
Q6P3F0
resolver
uniprot_sec
Q8VE12
resolver
amino_acid_sequence
MFDGYDSCSEDTSSSSSSEESEEEVAPLPSNLPIIKNNGQVYTYPDGKSGMATCEMCGMVGVRDAFYSKTKRFCSVSCSRSYSSNSKKASILARLQGKPPTKKAKVLQKQPLVAKLAAYAQYQATLQNQAKTKAGNSAISVEGFSWGNYINSNSFIAAPVACFKHAPMGTCWGDISENVRIEVPNTDCSLPTKVFWIAGIIKLAGYNALLRYEGFENDSSLDFWCNICGSDIHPVGWCAASGKPLVPPRTVQHKYTNWKAFLVKRLTGAKTLPPDFSQKVSESMQYPFKPCMRVEVVDKRHLCRTRVAVVESVIGGRLRLVYEESEDRTDDFWCHMHSPLIHHIGWSRSIGHRFKRSDITKKQDGHFDTPPHLFAKVKEVDQSGEWFKEGMKLEAIDPLNLSTICVATIRKVLADGFLMIGIDGSEAADGSDWFCYHATSPSIFPVGFCEINMIELTPPRGYTKLPFKWFDYLRETGSIAAPVKLFNKDVPNHGFRVGMKLEAVDLMEPRLICVATVTRIIHRLLRIHFDGWEEEYDQWVDCESPDLYPVGWCQLTGYQLQPPASQSSRESQSASSKQKKKAKSQQYKGHKKMTTSQLKEELLDGEDYSFLHGASDQESNGSATVYIKQEP
uniprot
proteins
function
FUNCTION: Chromatin reader component of the NuA4 histone acetyltransferase complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR). MBTD1 specifically recognizes and binds monomethylated and dimethylated 'Lys-20' on histone H4 (H4K20me1 and H4K20me2, respectively). In the NuA4 complex, MBTD1 promotes recruitment of the complex to H4K20me marks by competing with TP53BP1 for binding to H4K20me. Following recruitment to H4K20me at DNA breaks, the NuA4 complex catalyzes acetylation of 'Lys-15' on histone H2A (H2AK15), blocking the ubiquitination mark required for TP53BP1 localization at DNA breaks, thereby promoting homologous recombination (HR). {ECO:0000250|UniProtKB:Q05BQ5}.
uniprot
proteins
mass_dalton
70669
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
631
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q05BQ5}. Chromosome {ECO:0000250|UniProtKB:Q05BQ5}.
uniprot
proteins