Deptor
entrez
97998
canonical
uniprot
Q570Y9
canonical
ensembl
ENSMUSG00000022419
resolver
ensp
ENSMUSP00000023056
resolver
ensp
ENSMUSP00000094167
resolver
genesymbol
Deptor
resolver
genesymbol_syn
Depdc6
resolver
genesymbol_syn
Kiaa4200
resolver
uniprot
Q3UM00
resolver
uniprot
Q3UT08
resolver
uniprot_entry
DPTOR_MOUSE
resolver
uniprot_sec
Q3UM00
resolver
uniprot_sec
Q3UT08
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited upon phosphatidic acid-binding: phosphatidic acid produced upon mitogenic stimulation promotes DEPTOR dissociatiom from the mTORC1 and mTORC2 complexes, leading to their activation. Specifically binds unsaturated phosphatidic acid, such as 16:0-18:1, 18:0-18:1 and di-18:1. Inhibited when nutrients are present via a feedback loop: phosphorylation by MTOR promotes DEPTOR ubiquitination and degradation. {ECO:0000250|UniProtKB:Q8TB45}.
uniprot
proteins
amino_acid_sequence
MEEGSSGGSGSSDSNAGGSGGVQQRELERMAEVLVTGEQLRLRLHEEKVIKDRRHHLKTYPNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKDDGTFALDSEVKAFMRGQRLYEKLMSPETTLLQPREEEGVKYERTFMASEFLDWLVQEGEATTRKEAEQLCHRLMDHGIIQHVSNKHPFVDSNLLYQFRMNFRRRRRLMELLNETSPSSQETHDSPFCLRKQSHDSRKSTSFMSVSPSKEIKIVSAVRRSSMSSCGSSGYFSSSPTLSSSPPVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGPAAAAGMKVCQFVVSVNGLNVLNVDYRTVSNLILTGPRTIVMEVMEELDC
uniprot
proteins
function
FUNCTION: Negative regulator of the mTORC1 and mTORC2 complexes: inhibits the protein kinase activity of MTOR, thereby inactivating both complexes. DEPTOR inhibits mTORC1 and mTORC2 to induce autophagy. In contrast to AKT1S1/PRAS40, only partially inhibits mTORC1 activity. {ECO:0000250|UniProtKB:Q8TB45}.
uniprot
proteins
mass_dalton
46120
uniprot
proteins
post_translational_modification
PTM: Phosphorylation weakens interaction with MTOR within mTORC1 and mTORC2 (By similarity). Phosphorylated at Ser-286, Ser-287 and Ser-291 in response to mitogenic stimulation by MTOR: DEPTOR is either directly phosphorylated by MTOR or indirectly via proteins kinases that are activated by MTOR, such as CK1/CSNK1A1 (By similarity). Phosphorylation at Ser-286, Ser-287 and Ser-291 promotes ubiquitination by the SCF(BTRC) complex, followed by degradation (By similarity). Phosphorylation at Ser-235 by MAPK3/ERK1 promotes deubiquitination by USP7, enhancing its stability (By similarity). Phosphorylation at Tyr-291 by SYK impairs its interaction with MTOR, promoting mTORC1 and mTORC2 signaling (By similarity). {ECO:0000250|UniProtKB:Q8TB45}.; PTM: Ubiquitinated; leading to proteasomal degradation (By similarity). Ubiquitination by the SCF(BTRC) and SCF(FBXW11) complexes following phosphorylation at Ser-286, Ser-287 and Ser-291 by MTOR, leads to its degradation by the proteasome (By similarity). Deubiquitinated by OTUB1 in response to amino acid via a non-canonical mechanism, leading to DEPTOR stability (By similarity). Deubiquitinated by USP7 following phosphorylation at Ser-235, promoting its stability (By similarity). {ECO:0000250|UniProtKB:Q8TB45}.
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30232230
uniprot
proteins
sequence_length
409
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q8TB45}. Note=Localizes to the lysosomal membrane when associated with the mTORC1 and mTORC2 complexes. {ECO:0000250|UniProtKB:Q8TB45}.
uniprot
proteins