SEPT8
entrez
23176
canonical
uniprot
Q92599
canonical
ensembl
ENSG00000164402
resolver
ensp
ENSP00000296873
resolver
ensp
ENSP00000367973
resolver
ensp
ENSP00000367991
resolver
ensp
ENSP00000367993
resolver
ensp
ENSP00000394766
resolver
ensp
ENSP00000399840
resolver
ensp
ENSP00000548014
resolver
ensp
ENSP00000675837
resolver
enst
ENST00000378701
resolver
genesymbol
SEPT8
resolver
genesymbol
SEPTIN8
resolver
genesymbol_syn
KIAA0202
resolver
genesymbol_syn
SEPT8
resolver
hgnc
HGNC:16511
resolver
uniprot
A6NC65
resolver
uniprot
A6NFQ9
resolver
uniprot
A6NKP6
resolver
uniprot
B7ZVZ1
resolver
uniprot
F6W7K9
resolver
uniprot
Q8IX36
resolver
uniprot
Q8IX37
resolver
uniprot
Q9BVB3
resolver
uniprot_entry
A6NFQ9_HUMAN
resolver
uniprot_entry
B7ZVZ1_HUMAN
resolver
uniprot_entry
SEPT8_HUMAN
resolver
uniprot_sec
A6NC65
resolver
uniprot_sec
A6NKP6
resolver
uniprot_sec
F6W7K9
resolver
uniprot_sec
Q8IX36
resolver
uniprot_sec
Q8IX37
resolver
uniprot_sec
Q9BVB3
resolver
amino_acid_sequence
MAATDLERFSNAEPEPRSLSLGGHVGFDSLPDQLVSKSVTQGFSFNILCVGETGIGKSTLMNTLFNTTFETEEASHHEACVRLRPQTYDLQESNVQLKLTIVDAVGFGDQINKDESYRPIVDYIDAQFENYLQEELKIRRSLFDYHDTRIHVCLYFITPTGHSLKSLDLVTMKKLDSKVNIIPIIAKADTISKSELHKFKIKIMGELVSNGVQIYQFPTDDEAVAEINAVMNAHLPFAVVGSTEEVKVGNKLVRARQYPWGVVQVENENHCDFVKLREMLIRVNMEDLREQTHSRHYELYRRCKLEEMGFQDSDGDSQPFSLQETYEAKRKEFLSELQRKEEEMRQMFVNKVKETELELKEKERELHEKFEHLKRVHQEEKRKVEEKRRELEEETNAFNRRKAAVEALQSQALHATSQQPLRKDKDKKNRSDIGAHQPGMSLSSSKVMMTKASVEPLNCSSWWPAIQCCSCLVRDATWREGFL
uniprot
proteins
function
FUNCTION: Filament-forming cytoskeletal GTPase (By similarity). May play a role in platelet secretion (PubMed:15116257). Seems to participate in the process of SNARE complex formation in synaptic vesicles (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:B0BNF1, ECO:0000269|PubMed:15116257}.; FUNCTION: [Isoform 4]: Stabilizes BACE1 protein levels and promotes the sorting and accumulation of BACE1 to the recycling or endosomal compartments, modulating the beta-amyloidogenic processing of APP. {ECO:0000269|PubMed:27084579}.
uniprot
proteins
mass_dalton
55756
uniprot
proteins
protein_family
Septin GTPase family
uniprot
proteins
protein_family
TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily
uniprot
proteins
pubmed
10704283
uniprot
proteins
pubmed
12023038
uniprot
proteins
pubmed
12098780
uniprot
proteins
pubmed
12475938
uniprot
proteins
pubmed
12909369
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15116257
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15915442
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27084579
uniprot
proteins
pubmed
9039502
uniprot
proteins
sequence_length
483
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:B0BNF1}. Cytoplasm, cytoskeleton {ECO:0000250}. Synapse {ECO:0000250|UniProtKB:B0BNF1}. Cell projection, axon {ECO:0000250|UniProtKB:B0BNF1}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:B0BNF1}. Presynapse {ECO:0000250|UniProtKB:B0BNF1}. Note=Expressed in axons of immature neurons, localizes to synapses in mature neurons (By similarity). In platelets, found in areas surrounding alpha-granules (PubMed:15116257). {ECO:0000250|UniProtKB:B0BNF1, ECO:0000269|PubMed:15116257}.
uniprot
proteins