Hrh4
entrez
225192
canonical
uniprot
Q91ZY2
canonical
ensembl
ENSMUSG00000037346
resolver
ensp
ENSMUSP00000041061
resolver
ensp
ENSMUSP00000157130
resolver
enst
ENSMUST00000041676
resolver
enst
ENSMUST00000234565
resolver
genesymbol
Hrh4
resolver
uniprot
A0A3Q4EBY8
resolver
uniprot
B2ZGH2
resolver
uniprot
Q2M2N7
resolver
uniprot_entry
A0A3Q4EBY8_MOUSE
resolver
uniprot_entry
B2ZGH2_MOUSE
resolver
uniprot_entry
HRH4_MOUSE
resolver
uniprot_entry
Q2M2N7_MOUSE
resolver
amino_acid_sequence
MSESNSTGILPPAAQVPLAFLMSSFAFAIMVGNAVVILAFVVDRNLRHRSNYFFLNLAISDFLVGLISIPLYIPHVLFNWNFGSGICMFWLITDYLLCTASVYNIVLISYDRYQSVSNAVSYRAQHTGIMKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTKDCEPGFVTEWYILTITMLLEFLLPVISVAYFNVQIYWSLWKRRALSRCPSHAGFSTTSSSASGHLHRAGVACRTSNPGLKESAASRHSESPRRKSSILVSLRTHMNSSITAFKVGSFWRSESAALRQREYAELLRGRKLARSLAILLSAFAICWAPYCLFTIVLSTYPRTERPKSVWYSIAFWLQWFNSFVNPFLYPLCHRRFQKAFWKILCVTKQPALSQNQSVSS
uniprot
proteins
function
FUNCTION: G protein-coupled receptor primarily expressed in immune cells such as mast cells, eosinophils, basophils, dendritic cells and neutrophils that plays a key role in immune and inflammatory responses. Mediates chemotaxis of immune cells to sites of inflammation or injury by responding to histamine. Activation by histamine also influences the release of proinflammatory cytokines such as TNF, CCL4, IL6 and IFN-gamma. Ligand binding induces a conformation change that triggers signaling via G(i)/GNAI1 leading to decreased intracellular cAMP levels by inhibiting adenylate cyclase activity (By similarity). In addition, plays a role in the control of renal reabsorption processes, particularly albumin uptake (PubMed:34680152). {ECO:0000250|UniProtKB:Q9H3N8, ECO:0000269|PubMed:34680152}.
uniprot
proteins
mass_dalton
44249
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
34680152
uniprot
proteins
sequence_length
391
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9H3N8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9H3N8}.
uniprot
proteins
transmembrane_region
TRANSMEM 20..40; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 53..73; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 88..108; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 132..152; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 175..195; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 307..327; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 344..364; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins