Dkk4
entrez
234130
canonical
uniprot
Q8VEJ3
canonical
ensembl
ENSMUSG00000031535
resolver
ensp
ENSMUSP00000033936
resolver
enst
ENSMUST00000033936
resolver
genesymbol
Dkk4
resolver
uniprot_entry
DKK4_MOUSE
resolver
amino_acid_sequence
MVLVTLLGLSWFCSPLAALVLDFNNIKSSADVQGAGKGSLCASDRDCSEGKFCLAFHDERSFCATCRRVRRRCQRSAVCCPGTVCVNDVCTAVEDTRPVMDRNTDGQDGAYAEGTTKWPAEENRPQGKPSTKKSQSSKGQEGESCLRTSDCGPGLCCARHFWTKICKPVLREGQVCSRRGHKDTAQAPEIFQRCDCGPGLTCRSQVTSNRQHSRLRVCQRI
uniprot
proteins
function
FUNCTION: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
24261
uniprot
proteins
protein_family
Dickkopf family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17143291
uniprot
proteins
sequence_length
221
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
uniprot
proteins