Abcb6
entrez
74104
canonical
uniprot
Q9DC29
canonical
ensembl
ENSMUSG00000026198
resolver
ensp
ENSMUSP00000027396
resolver
enst
ENSMUST00000027396
resolver
genesymbol
Abcb6
resolver
uniprot
Q3U7N5
resolver
uniprot
Q3UAZ6
resolver
uniprot_entry
ABCB6_MOUSE
resolver
uniprot_sec
Q3U7N5
resolver
uniprot_sec
Q3UAZ6
resolver
amino_acid_sequence
MVTVGNYCETEGPAGPAWTQNGLSPCFFFTLVPSTLLTLGVLALVLVLPRRRREVPAGPEELSWAAGPRVAPYVLQLFLATLQMALPLAGLAGRVGTARGVRLPGYLLLASVLESLASVCGLWLLVVERSQARQSLAMGVWMKFRHSLGLLLLWTVTFAAENLALVSWNSPQWWWARADLGQQVQFGLWVLRYVTSGGLFILGLWAPGLRPQSYTLHVHEEDQDVGGNQGRSTDRRSTWRDLGRKLRLLSSYLWPRGSPSLQLIVLICLGLMGLERALNVLVPIFYRDIVNLLTAKAPWSSLAWTVTTYVFLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRGVELRLFSHLHELSLRWHLGRRTGEVLRIVDRGTSSVTGLLSYLVFSIIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLILTIVVTEWRAKFRRDMNTQENATRARAVDSLLNFETVKYYGAEGYEVDRYREAILKFQGLEWKSTASLVVLNQTQNLVIGLGLLAGSLLCAYFVSEQKLQVGDFVLFGTYITQLYMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDVPGAGPLRFHKGRIEFENVHFSYADGQETLQDVSFTVMPGQTVALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQISLRSHIGVVPQDTVLFNDTIANNIRYGRVTAGDSEVEAAAQAAGIHDAILSFPEGYETQVGERGLKLSGGEKQRVAIARTILKAPDIILLDEATSALDTSNERAIQASLAKVCTNRTTIVIAHRLSTVVNADQILVIKDGCIIERGRHEALLSRGGVYAEMWQLQQQGQETVPEESKPQDTA
uniprot
proteins
ec_number
7.6.2.5
uniprot
proteins
function
FUNCTION: ATP-dependent transporter that catalyzes the transport of a broad-spectrum of porphyrins from the cytoplasm to the extracellular space through the plasma membrane or into the vesicle lumen (PubMed:27507172). May also function as an ATP-dependent importer of porphyrins from the cytoplasm into the mitochondria, in turn may participate in the de novo heme biosynthesis regulation and in the coordination of heme and iron homeostasis during phenylhydrazine stress (PubMed:17006453, PubMed:22294697). May play a key role in the early steps of melanogenesis producing PMEL amyloid fibrils (By similarity). In vitro, it confers to cells a resistance to toxic metal such as arsenic and cadmium and against chemotherapeutics agent such as 5-fluorouracil, SN-38 and vincristin (By similarity). In addition may play a role in the transition metal homeostasis (By similarity). {ECO:0000250|UniProtKB:O70595, ECO:0000250|UniProtKB:Q9NP58, ECO:0000269|PubMed:17006453, ECO:0000269|PubMed:22294697, ECO:0000269|PubMed:27507172}.
uniprot
proteins
mass_dalton
93770
uniprot
proteins
mutagenesis
MUTAGEN 170; /note="S->G: Results in retention of the protein in the Golgi apparatus."; /evidence="ECO:0000269|PubMed:23519333"; MUTAGEN 356; /note="L->P: Results in retention of the protein in the Golgi apparatus."; /evidence="ECO:0000269|PubMed:23519333"; MUTAGEN 579; /note="G->E: Results in retention of the protein in the Golgi apparatus."; /evidence="ECO:0000269|PubMed:23519333
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:21199866}.
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCB family
uniprot
proteins
protein_family
Heavy Metal importer (TC 3.A.1.210) subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17006453
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21199866
uniprot
proteins
pubmed
21266531
uniprot
proteins
pubmed
22294697
uniprot
proteins
pubmed
22655043
uniprot
proteins
pubmed
23519333
uniprot
proteins
pubmed
27507172
uniprot
proteins
sequence_length
842
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9NP58}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion outer membrane {ECO:0000269|PubMed:17006453}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9NP58}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9NP58}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:23519333}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:Q9NP58}. Late endosome membrane {ECO:0000250|UniProtKB:O70595}. Early endosome membrane {ECO:0000250|UniProtKB:O70595}. Secreted, extracellular exosome {ECO:0000269|PubMed:22655043}. Mitochondrion {ECO:0000250|UniProtKB:Q9NP58}. Endosome, multivesicular body membrane {ECO:0000250|UniProtKB:Q9NP58}. Melanosome membrane {ECO:0000250|UniProtKB:Q9NP58}. Note=Present in the membrane of mature erythrocytes and in exosomes released from reticulocytes during the final steps of erythroid maturation. Traffics from endoplasmic reticulum to Golgi during its glycans's maturation, therefrom is first targeted to the plasma membrane, and is rapidly internalized through endocytosis to be distributed to the limiting membrane of multivesicular bodies and lysosomes. Localized on the limiting membrane of early melanosomes of pigment cells (By similarity). Targeted to the endolysosomal compartment (By similarity). {ECO:0000250|UniProtKB:O70595, ECO:0000250|UniProtKB:Q9NP58}.
uniprot
proteins
transmembrane_region
TRANSMEM 27..47; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 73..93; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 107..127; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 148..168; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 186..206; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 264..284; /note="Helical"; /evidence="ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 292..312; /note="Helical"; /evidence="ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 376..396; /note="Helical"; /evidence="ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 398..418; /note="Helical"; /evidence="ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 500..520; /note="Helical"; /evidence="ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 530..550; /note="Helical"; /evidence="ECO:0000255, ECO:0000255|PROSITE-ProRule:PRU00441
uniprot
proteins