Ift27
entrez
67042
canonical
uniprot
Q9D0P8
canonical
ensembl
ENSMUSG00000016637
resolver
ensp
ENSMUSP00000016781
resolver
enst
ENSMUST00000016781
resolver
genesymbol
Ift27
resolver
genesymbol_syn
Rabl4
resolver
genesymbol_syn
Rayl
resolver
uniprot_entry
IFT27_MOUSE
resolver
amino_acid_sequence
MVKLAAKCILAGDPAVGKTALVQMFRSDGTHFQKNYTLTTGVDLVVKTVPVLDTNDSVELFIFDSAGKELFSEMLDKLWENPNVLCLVYDVTNEQSFISCTKWLEKVRSQTSGISLPGVLVGTKTDLAGRQTVDSAQAQVWALSQGLEFFETSVKEMDNYEAPFHCLAKQFYQLYREKVDIFHTLV
uniprot
proteins
function
FUNCTION: Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6 (PubMed:25446516). Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6. Required for hedgehog signaling (PubMed:25446516). Forms a subcomplex within the IFT complex B with IFT25 (By similarity). Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation (PubMed:28964737). Plays a role in the early development of the kidney (PubMed:29626631). May be involved in the regulation of ureteric bud initiation (PubMed:29626631). {ECO:0000250|UniProtKB:A8HN58, ECO:0000269|PubMed:25446516, ECO:0000269|PubMed:28964737, ECO:0000269|PubMed:29626631}.
uniprot
proteins
mass_dalton
20814
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19253336
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23055941
uniprot
proteins
pubmed
23810713
uniprot
proteins
pubmed
25446516
uniprot
proteins
pubmed
28430876
uniprot
proteins
pubmed
28964737
uniprot
proteins
pubmed
29626631
uniprot
proteins
sequence_length
186
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:19253336}. Cytoplasm {ECO:0000269|PubMed:28964737}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:28964737}. Note=Localizes to the sperm flagellum. {ECO:0000269|PubMed:28964737}.
uniprot
proteins