MICALL2
entrez
79778
canonical
uniprot
Q8IY33
canonical
ensembl
ENSG00000164877
resolver
ensp
ENSP00000297508
resolver
ensp
ENSP00000405415
resolver
ensp
ENSP00000665304
resolver
genesymbol
MICALL2
resolver
genesymbol_syn
JRAB
resolver
hgnc
HGNC:29672
resolver
uniprot
D3YTD2
resolver
uniprot
Q7RTP4
resolver
uniprot
Q7Z655
resolver
uniprot
Q8TEQ4
resolver
uniprot
Q9H5F9
resolver
uniprot_entry
MILK2_HUMAN
resolver
uniprot_sec
D3YTD2
resolver
uniprot_sec
Q7RTP4
resolver
uniprot_sec
Q7Z655
resolver
uniprot_sec
Q8TEQ4
resolver
uniprot_sec
Q9H5F9
resolver
amino_acid_sequence
MAAIRALQQWCRQQCEGYRDVNICNMTTSFRDGLAFCAILHRHRPDLINFSALKKENIYENNKLAFRVAEEHLGIPALLDAEDMVALKVPDRLSILTYVSQYYNYFHGRSPIGGMAGVKRASEDSEEEPSGKKAPVQAAKLPSPAPARKPPLSPAQTNPVVQRRNEGAGGPPPKTDQALAGSLVSSTCGVCGKHVHLVQRHLADGRLYHRSCFRCKQCSCTLHSGAYKATGEPGTFVCTSHLPAAASASPKLTGLVPRQPGAMGVDSRTSCSPQKAQEANKARPSAWEPAAGNSPARASVPAAPNPAATSATSVHVRSPARPSESRLAPTPTEGKVRPRVTNSSPMGWSSAAPCTAAAASHPAVPPSAPDPRPATPQGGGAPRVAAPQTTLSSSSTSAATVDPPAWTPSASRTQQARNKFFQTSAVPPGTSLSGRGPTPSLVLSKDSSKEQARNFLKQALSALEEAGAPAPGRPSPATAAVPSSQPKTEAPQASPLAKPLQSSSPRVLGLPSRMEPPAPLSTSSTSQASALPPAGRRNLAESSGVGRVGAGSRPKPEAPMAKGKSTTLTQDMSTSLQEGQEDGPAGWRANLKPVDRRSPAERTLKPKEPRALAEPRAGEAPRKVSGSFAGSVHITLTPVRPDRTPRPASPGPSLPARSPSPPRRRRLAVPASLDVCDNWLRPEPPGQEARVQSWKEEEKKPHLQGKPGRPLSPANVPALPGETVTSPVRLHPDYLSPEEIQRQLQDIERRLDALELRGVELEKRLRAAEGDDAEDSLMVDWFWLIHEKQLLLRQESELMYKSKAQRLEEQQLDIEGELRRLMAKPEALKSLQERRREQELLEQYVSTVNDRSDIVDSLDEDRLREQEEDQMLRDMIEKLGLQRKKSKFRLSKIWSPKSKSSPSQ
uniprot
proteins
function
FUNCTION: Effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecules transport to the plasma membrane and actin cytoskeleton reorganization. Regulates the endocytic recycling of occludins, claudins and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. In parallel, may regulate actin cytoskeleton reorganization directly through interaction with F-actin or indirectly through actinins and filamins. Most probably involved in the processes of epithelial cell differentiation, cell spreading and neurite outgrowth (By similarity). Undergoes liquid-liquid phase separation to form tubular recycling endosomes. Plays 2 sequential roles in the biogenesis of tubular recycling endosomes: first organizes phase separation and then the closed form formed by interaction with RAB8A promotes endosomal tubulation (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q3TN34}.
uniprot
proteins
mass_dalton
97502
uniprot
proteins
pubmed
12110185
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16525024
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23890175
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
904
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q3TN34}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q3TN34}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q3TN34}. Recycling endosome {ECO:0000250|UniProtKB:Q3TN34}. Cell projection {ECO:0000250|UniProtKB:Q3TN34}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q3TN34}.
uniprot
proteins