Pdcd6ip
entrez
18571
canonical
uniprot
Q9WU78
canonical
ensembl
ENSMUSG00000032504
resolver
ensp
ENSMUSP00000035086
resolver
ensp
ENSMUSP00000107492
resolver
ensp
ENSMUSP00000162416
resolver
ensp
ENSMUSP00000162417
resolver
genesymbol
Pdcd6ip
resolver
genesymbol_syn
Aip1
resolver
genesymbol_syn
Alix
resolver
uniprot
O88695
resolver
uniprot
O89014
resolver
uniprot
Q3TED2
resolver
uniprot
Q80Y09
resolver
uniprot
Q8BSL8
resolver
uniprot
Q8R0H5
resolver
uniprot
Q99LR3
resolver
uniprot
Q9QZN8
resolver
uniprot_entry
PDC6I_MOUSE
resolver
uniprot_entry
Q80Y09_MOUSE
resolver
uniprot_sec
O88695
resolver
uniprot_sec
O89014
resolver
uniprot_sec
Q3TED2
resolver
uniprot_sec
Q8BSL8
resolver
uniprot_sec
Q8R0H5
resolver
uniprot_sec
Q99LR3
resolver
uniprot_sec
Q9QZN8
resolver
amino_acid_sequence
MASFIWVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQAQYCRAAEELSKLRRSALGRPLDKHEGALETLLRYYDQICSIEPKFPFSENQICLTFTWKDAFDKGSLFGGSVKLALASLGYEKSCVLFNCAALASQIAAEQNLDNDEGLKTAAKQYQFASGAFLHIKDTVLSALSREPTVDISPDTVGTLSLIMLAQAQEVFFLKATRDKMKDAIIAKLANQAADYFGDAFKQCQYKDTLPKEVFPTLAAKQCIMQANAEYHQSILAKQQKKFGEEIARLQHAAELIKNVASRYDEYVNVKDFSDKINRALTAAKKDNDFIYHDRVPDLKDLDPIGKATLVKPTPVNVPVSQKFTDLFEKMVPVSVQQSLAVFSQRKADLVNRSIAQMREATTLANGVLASLNLPAAIEDVSGDTVPQSILTKSTSVVEQGGIQTVDQLIKELPELLQRNREILEESLRLLDEEEATDNDLRAKFKDRWQRTPSNDLYKPLRAEGAKFRAVLDKAVQADGQVKERYQSHRDTIALLCKPEPELNAAIPSANPAKTMQGSEVVSVLKSLLSNLDEIKKERESLENDLKSVNFDMTSKFLTALAQDGVINEEALSVTELDRIYGGLTSKVQESLKKQEGLLKNIQVSHQEFSKMKQSNNEANLREEVLKNLATAYDNFVELVANLKEGTKFYNELTEILVRFQNKCSDIVFARKTERDELLKDLQQSIAREPSAPSIPPPAYQSSPAAGHAAAPPTPAPRTMPPAKPQPPARPPPPVLPANRVPPASAAAAPAGVGTASAAPPQTPGSAPPPQAQGPPYPTYPGYPGYCQMPMPMGYNPYAYGQYNMPYPPVYHQSPGQAPYPGPQQPTYPFPQPPQQSYYPQQ
uniprot
proteins
function
FUNCTION: Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway requires the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. May play a role in the regulation of both apoptosis and cell proliferation. Regulates exosome biogenesis in concert with SDC1/4 and SDCBP (By similarity). By interacting with F-actin, PARD3 and TJP1 secures the proper assembly and positioning of actomyosin-tight junction complex at the apical sides of adjacent epithelial cells that defines a spatial membrane domain essential for the maintenance of epithelial cell polarity and barrier (PubMed:27336173). {ECO:0000250|UniProtKB:Q8WUM4, ECO:0000269|PubMed:27336173}.
uniprot
proteins
mass_dalton
96024
uniprot
proteins
post_translational_modification
PTM: May be phosphorylated on tyrosine residues by activated PDGFRB. {ECO:0000250|UniProtKB:Q8WUM4}.
uniprot
proteins
pubmed
10200558
uniprot
proteins
pubmed
10556317
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22660413
uniprot
proteins
pubmed
23523921
uniprot
proteins
pubmed
25686249
uniprot
proteins
pubmed
27336173
uniprot
proteins
pubmed
9880530
uniprot
proteins
sequence_length
869
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9QZA2}. Melanosome {ECO:0000250|UniProtKB:Q8WUM4}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q8WUM4}. Secreted, extracellular exosome {ECO:0000269|PubMed:23523921}. Cell junction, tight junction {ECO:0000269|PubMed:27336173}. Midbody, Midbody ring {ECO:0000250|UniProtKB:Q8WUM4}. Note=Colocalized with CEP55 in the midbody during cytokinesis and at centrosomes in non-dividing cells (By similarity). Component of the actomyosin-tight junction complex (PubMed:27336173). {ECO:0000250|UniProtKB:Q8WUM4, ECO:0000269|PubMed:27336173}.
uniprot
proteins