Myzap
entrez
363091
canonical
uniprot
Q5EB94
canonical
ensembl
ENSRNOG00000071258
resolver
ensp
ENSRNOP00000110374
resolver
genesymbol
Myzap
resolver
genesymbol_syn
Myozap
resolver
uniprot_entry
MYZAP_RAT
resolver
amino_acid_sequence
MLRSTSTVTLLSGGSAKSPGTPSRRANVCRLRLTVPPENPVPQQKEKKIERKDQPPELSNGESTKKLPQGVVYGVVRRSDPNQQKEMVVYGWSTNQLKEEMNYIKDVRATLEKVRKRMYGDYDEMRQKIRQLTQDLSVSHAQQDYLDSHIQAQASALDSFNAMNSALALDSVGLQKTLVDVTLENSNIKDQIRHLQQTYEASMDKLREKQRQLEAAQMENQLLKMRVESSQEANAEVMREMTRKLYSQYEEKLQEAQRKHSAEKEVLLEETNSFLKAIEEANKKMEAAELSLEEKDQRIGELDRLIERMEKERHQLQLQLLEHETEMSGEMADFDKNRYQQLEEASASLRERIRHLDDMVHCQQKKVKQMVEEIESLKKKVQQKQLLILQLLEKISFLEGENNELQSRLDYLTETQPKTEVETREIGVGCDLLPSTTGRTREIAVPSRSYTPYTRVLELTSKKTLT
uniprot
proteins
function
FUNCTION: Plays a role in cellular signaling via Rho-related GTP-binding proteins and activation of transcription factor SRF. Targets TJP1 to cell junctions (By similarity). In cortical neurons, may play a role in glutaminergic signal transduction through interaction with the NMDA receptor subunit GRIN1. {ECO:0000250, ECO:0000269|PubMed:18849881}.
uniprot
proteins
mass_dalton
53955
uniprot
proteins
protein_family
MYZAP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18849881
uniprot
proteins
pubmed
20093627
uniprot
proteins
pubmed
29445566
uniprot
proteins
pubmed
31384490
uniprot
proteins
sequence_length
466
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20093627}. Cell membrane {ECO:0000269|PubMed:18849881, ECO:0000269|PubMed:20093627}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q3UIJ9}; Cytoplasmic side {ECO:0000250|UniProtKB:Q3UIJ9}. Cytoplasm, myofibril, sarcomere, I band {ECO:0000250|UniProtKB:Q3UIJ9}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:Q3UIJ9}. Cell junction {ECO:0000269|PubMed:29445566, ECO:0000269|PubMed:31384490}. Note=Detected predominantly at the intercalated disk in cardiomyocytes, and at low levels on sarcomeric Z disKs. Colocalizes with F-actin. Colocalizes with cortical actin (PubMed:20093627). In neurons, colocalizes with GRIN1 in postsynaptic neurites (PubMed:18849881). In heart, localizes at area composita, the mixed-type junctional structure composed of both desmosomal and adherens junctional proteins (PubMed:31384490). {ECO:0000269|PubMed:18849881, ECO:0000269|PubMed:20093627, ECO:0000269|PubMed:31384490}.
uniprot
proteins