GPR25
entrez
2848
canonical
uniprot
O00155
canonical
ensembl
ENSG00000170128
resolver
ensp
ENSP00000301917
resolver
enst
ENST00000304244
resolver
genesymbol
GPR25
resolver
hgnc
HGNC:4480
resolver
uniprot
A0AVJ5
resolver
uniprot_entry
GPR25_HUMAN
resolver
uniprot_sec
A0AVJ5
resolver
amino_acid_sequence
MAPTEPWSPSPGSAPWDYSGLDGLEELELCPAGDLPYGYVYIPALYLAAFAVGLLGNAFVVWLLAGRRGPRRLVDTFVLHLAAADLGFVLTLPLWAAAAALGGRWPFGDGLCKLSSFALAGTRCAGALLLAGMSVDRYLAVVKLLEARPLRTPRCALASCCGVWAVALLAGLPSLVYRGLQPLPGGQDSQCGEEPSHAFQGLSLLLLLLTFVLPLVVTLFCYCRISRRLRRPPHVGRARRNSLRIIFAIESTFVGSWLPFSALRAVFHLARLGALPLPCPLLLALRWGLTIATCLAFVNSCANPLIYLLLDRSFRARALDGACGRTGRLARRISSASSLSRDDSSVFRCRAQAANTASASW
uniprot
proteins
function
FUNCTION: Receptor for the C-X-C chemokine CXCL17, which plays a key role in lymphocyte homing (PubMed:39293486, PubMed:40279398). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as RhoA pathway (PubMed:39293486). Activation by CXCL17 on lymphocytes activates the RhoA pathway, which regulates cytoskeletal dynamics and integrins, mediating lymphocyte recruitment into the respiratory, upper gastrointestinal, biliary and genito-urinary tracts (PubMed:39293486). {ECO:0000269|PubMed:39293486, ECO:0000269|PubMed:40279398}.
uniprot
proteins
mass_dalton
38779
uniprot
proteins
mutagenesis
MUTAGEN 95; /note="W->A: Abolished ability to be activated by CXCL17."; /evidence="ECO:0000269|PubMed:40279398"; MUTAGEN 178; /note="R->A: Abolished ability to be activated by CXCL17."; /evidence="ECO:0000269|PubMed:40279398
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
39293486
uniprot
proteins
pubmed
40279398
uniprot
proteins
pubmed
9020062
uniprot
proteins
sequence_length
361
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:40279398}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..60; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 76..96; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 127..147; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 156..176; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 201..220; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 243..263; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 290..310; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins