Hhat
entrez
226861
canonical
uniprot
Q8BMT9
canonical
ensembl
ENSMUSG00000037375
resolver
ensp
ENSMUSP00000046686
resolver
genesymbol
Hhat
resolver
genesymbol_syn
Skn
resolver
uniprot
B1ANS0
resolver
uniprot
Q3TA33
resolver
uniprot
Q922G3
resolver
uniprot_entry
HHAT_MOUSE
resolver
uniprot_sec
B1ANS0
resolver
uniprot_sec
Q3TA33
resolver
uniprot_sec
Q922G3
resolver
amino_acid_sequence
MLPGWELTLCLLVSLGFHFRSFYEVYKVSREHEEELDQEFELEMDTLFGGLKKDPTDFEWNFWMEWGKRRLVWLFIGHMAVSQLATLLTKKHRPWIVMVYGMWACWCVLGAPGVVMVLLHSTIAFCVAQFRSVLLSWLCSLLLLSTLRLQSVEEVKRRWYKTENEYYLLQFTLTVRCLYYTSFSLELCRQPPSAQPTPSAQGASHSYPWLLTYVFYYPVFHNGPILNFPEFFRQMQQPELNSLQHSLCIVAKGLGRLLCWWWLAELMVHLMYMHALYSSAPLLESVSCWTLGGLALAQVLFFYVKYLVLFGVPALLMRLDGLTPPPLPRCVSTMFSFTGMWRYFDVGLHNFLIRYVYIPLGGSQHGLLGTLLSTATTFAFVSYWHGSYEDLWCWAALNWLGVTVESGVRRLLETPCVRETLARHLSPQAHHRLHALLAACSTSMLILFNLVFLGGIQVGKTYWNRIFLQGWPWVTLSVLGFLYCYSHVDIAWAQTYTVL
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
function
FUNCTION: Palmitoyl acyltransferase that catalyzes N-terminal palmitoylation of hedgehog (DHH, IHH or SHH) morphogens, promoting their maturation (PubMed:15075292, PubMed:23112049, PubMed:25488661). Promotes the transfer of palmitoyl-CoA from the cytoplasmic to the luminal side of the endoplasmic reticulum membrane, where hedgehog palmitoylation occurs (PubMed:23112049). Required for hedgehog signaling during limb development (PubMed:15075292). Plays a role in proper testis cord formation and the differentiation of Leydig cells (PubMed:24784881). {ECO:0000269|PubMed:15075292, ECO:0000269|PubMed:23112049, ECO:0000269|PubMed:24784881, ECO:0000269|PubMed:25488661}.
uniprot
proteins
mass_dalton
57864
uniprot
proteins
protein_family
HHAT subfamily
uniprot
proteins
protein_family
Membrane-bound acyltransferase family
uniprot
proteins
pubmed
15075292
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18081866
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23112049
uniprot
proteins
pubmed
24784881
uniprot
proteins
pubmed
25488661
uniprot
proteins
sequence_length
499
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15075292, ECO:0000269|PubMed:18081866, ECO:0000269|PubMed:25488661}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q5VTY9}; Multi-pass membrane protein {ECO:0000255}. Note=Co-localizes with SHH in the ER and Golgi membrane. {ECO:0000250|UniProtKB:Q5VTY9}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..23; /note="Helical; Name=alpha1"; /evidence="ECO:0000305|PubMed:25488661"; TRANSMEM 69..85; /note="Helical; Name=alpha2"; /evidence="ECO:0000305|PubMed:25488661"; TRANSMEM 133..149; /note="Helical; Name=alpha5"; /evidence="ECO:0000305|PubMed:25488661"; TRANSMEM 167..185; /note="Helical; Name=alpha6"; /evidence="ECO:0000305|PubMed:25488661"; TRANSMEM 246..268; /note="Helical; Name=alpha7"; /evidence="ECO:0000305|PubMed:25488661"; TRANSMEM 291..320; /note="Helical; Name=alpha8"; /evidence="ECO:0000305|PubMed:25488661"; TRANSMEM 367..385; /note="Helical; Name=alpha9"; /evidence="ECO:0000305|PubMed:25488661"; TRANSMEM 392..408; /note="Helical; Name=alpha10"; /evidence="ECO:0000305|PubMed:25488661"; TRANSMEM 432..455; /note="Helical; Name=alpha11"; /evidence="ECO:0000305|PubMed:25488661"; TRANSMEM 472..492; /note="Helical; Name=alpha12"; /evidence="ECO:0000305|PubMed:25488661
uniprot
proteins