Rnf138
entrez
94196
canonical
uniprot
Q99PD2
canonical
ensembl
ENSRNOG00000015645
resolver
ensembl
ENSRNOG00055018403
resolver
ensembl
ENSRNOG00060012283
resolver
ensembl
ENSRNOG00065015419
resolver
ensp
ENSRNOP00000021061
resolver
ensp
ENSRNOP00000084639
resolver
ensp
ENSRNOP00000091039
resolver
ensp
ENSRNOP00055025233
resolver
ensp
ENSRNOP00060016436
resolver
ensp
ENSRNOP00065020107
resolver
enst
ENSRNOT00000100953
resolver
enst
ENSRNOT00000102423
resolver
enst
ENSRNOT00055031274
resolver
enst
ENSRNOT00060020850
resolver
enst
ENSRNOT00065025598
resolver
genesymbol
Rnf138
resolver
genesymbol_syn
AABR07031480.1
resolver
uniprot
A0A8I6ABB7
resolver
uniprot_entry
A0A8I6ABB7_RAT
resolver
uniprot_entry
RN138_RAT
resolver
amino_acid_sequence
MSEELSADTSYTEDDFYCPVCQEVLKTPVRTAACQHVFCRKCFLTAMRESGIHCPLCRGSVTRRERACPERAIDLENIMRRVSGSCRCCSKKIKFYRMRHHYKSCKKYQDEYGVSSVIPNVKISQDSVRSSNRSETSASDNTETYQEDTSSSGHPTFKCPLCQESNFTRQRLLDHCNSNHLFQIVPVNLQLDEETQYQTAVEESFQVNM
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination. Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination. Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination. According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway. {ECO:0000250|UniProtKB:Q8WVD3}.
uniprot
proteins
mass_dalton
24072
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q8WVD3}.
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated. {ECO:0000250|UniProtKB:Q8WVD3}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
209
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q8WVD3}. Note=Recruited at DNA damage sites. Localizes to sites of double-strand break: localization to double-strand break sites is mediated by the zinc fingers. {ECO:0000250|UniProtKB:Q8WVD3}.
uniprot
proteins