Ptprn2
entrez
29714
canonical
uniprot
Q63475
canonical
ensembl
ENSRNOG00000005003
resolver
ensembl
ENSRNOG00055005045
resolver
ensembl
ENSRNOG00060014787
resolver
ensembl
ENSRNOG00065007303
resolver
ensp
ENSRNOP00000006942
resolver
ensp
ENSRNOP00000093030
resolver
ensp
ENSRNOP00000110350
resolver
ensp
ENSRNOP00055006063
resolver
ensp
ENSRNOP00060020152
resolver
ensp
ENSRNOP00065008299
resolver
enst
ENSRNOT00000116222
resolver
enst
ENSRNOT00000160214
resolver
enst
ENSRNOT00055008052
resolver
enst
ENSRNOT00060025292
resolver
enst
ENSRNOT00065011395
resolver
genesymbol
Ptprn2
resolver
uniprot
A0A8I6AHT8
resolver
uniprot_entry
A0A8I6AHT8_RAT
resolver
uniprot_entry
PTPR2_RAT
resolver
amino_acid_sequence
MGLPLPLLLLLLLPPPLPRALPAPASARGRQLPGRLGCLFEDGLCGSLETCVNDGVFGRCQKVPALDTYRYEVSPGALLHLRIILQKLSRTGFTWQDDYTQRVIAQELSNLPKAYLWHEEASSPARSLQQNADNEKWFSLESEVALAKTLRRYLPYLELLSQAPTANAHPRIDHETRPVKGEDSSPENILTYVAHTSALTYPPATRVKYPDNLLRPLSRLQPDELSPKVDSDIDKQKLIAALGAYTAQRPPGENDPEPRYLVHSPMRAPRPFAAPALSQRWPLPPGDSKDSLSMGDDTLLRSLLKDLQQQAEVDRLGSLKLEEQADSIAGAIQSDPVEGSQESHGRGAEGQLREQADAPEEMLQDHRLPEVDDPAAYKEVSRLSFKLGDLLKDHGSPLLPEAPLLEKSSRAEMKKSEQPEEVLSSEEETAGVEHVKSRTYSKDLLERKPNSEPQPWRLEDQFQNRAPEVWEDEQNLKLAAQGPPSGGLQLEVQPSEEEQQGYILTGNNPLSPEKGKQLMDEVAHLLRVPSSFFADVKVLGPAVIFKVSANIQNMTTADVTKAAVDNKDELEKATGLTILQSGIRPKGKLKLLPHPEEQEDSTKFIVLTFLSIACILAVLLASSLAYCLRHNSHYKLKEKLSGLGADPSADATEAYQELCRQRMAVRPQDHSEGPHTSRINSVSSQLSDGPMPSPSARSSTSSWSEEPAQSNMDISTGHMILAYMEDHLKNKNRLEKEWEALCAYQAEPDSSLVAQREENAPKNRSLAVLTYDHSRILLKSENSHSNSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCAVIVMLTPLSENGVRQCHHYWPDEGSNVYHVYEVNLVSEHIWCQDFLVRSFYLKNLQTNETRTVTQFHFLSWYDQGVPSSTRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNAILKALPQ
uniprot
proteins
ec_number
3.1.3.-
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Required to maintain normal levels of renin expression and renin release. May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity). Has phosphatidylinositol phosphatase activity; the PIPase activity is involved in its ability to regulate insulin secretion. Can dephosphorylate phosphatidylinositol 4,5-biphosphate, phosphatidylinositol 5-phosphate and phosphatidylinositol 3-phosphate (PubMed:20097759). Regulates PI(4,5)P2 level in the plasma membrane and localization of cofilin at the plasma membrane and thus is indirectly involved in regulation of actin dynamics related to cell migration and metastasis; upon hydrolysis of PI(4,5)P2 cofilin is released from the plasma membrane and acts in the cytoplasm in severing F-actin filaments (By similarity). {ECO:0000250|UniProtKB:P80560, ECO:0000269|PubMed:20097759}.
uniprot
proteins
mass_dalton
111863
uniprot
proteins
mutagenesis
MUTAGEN 655; /note="Y->A: Impairs internalization; decreases interaction with AP2M1."; /evidence="ECO:0000269|PubMed:15882444
uniprot
proteins
post_translational_modification
PTM: Subject to proteolytic cleavage at multiple sites. {ECO:0000250|UniProtKB:P80560}.
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
protein_family
Receptor class 8 subfamily
uniprot
proteins
pubmed
11353772
uniprot
proteins
pubmed
14597614
uniprot
proteins
pubmed
15882444
uniprot
proteins
pubmed
20097759
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
25744490
uniprot
proteins
pubmed
8663434
uniprot
proteins
sequence_length
1004
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:14597614}; Single-pass type I membrane protein {ECO:0000269|PubMed:14597614}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P80560}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P80560}. Note=Predominantly found on dense-core secretory granules. Sorting to secretory granules in part is dependent of the N-terminal propeptide domain of the precursor and its interaction with CPE (By similarity). Transiently found at the cell membrane, when secretory vesicles fuse with the cell membrane to release their cargo. Is then endocytosed and recycled to secretory vesicles involving clathrin-dependent AP2-mediated endocytosis (PubMed:15882444). Recycled via STX6- but not TTTGN1/TGN38-containing compartments (By similarity). {ECO:0000250|UniProtKB:P80560, ECO:0000269|PubMed:15882444, ECO:0000305}.; SUBCELLULAR LOCATION: [IA-2beta60]: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 604..624; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins