Cbfa2t2
entrez
12396
canonical
uniprot
O70374
canonical
ensembl
ENSMUSG00000038533
resolver
ensp
ENSMUSP00000043087
resolver
ensp
ENSMUSP00000096782
resolver
ensp
ENSMUSP00000105347
resolver
ensp
ENSMUSP00000118371
resolver
ensp
ENSMUSP00000239850
resolver
ensp
ENSMUSP00000239855
resolver
enst
ENSMUST00000099178
resolver
enst
ENSMUST00000109725
resolver
genesymbol
Cbfa2t2
resolver
genesymbol_syn
Cbfa2t2h
resolver
genesymbol_syn
Mtgr1
resolver
uniprot
A0A0R4J1D5
resolver
uniprot
B2RRH8
resolver
uniprot
F6S3J7
resolver
uniprot
Q30BK8
resolver
uniprot
Q3UGB2
resolver
uniprot
Q6P288
resolver
uniprot_entry
A0A0R4J1D5_MOUSE
resolver
uniprot_entry
F6S3J7_MOUSE
resolver
uniprot_entry
MTG8R_MOUSE
resolver
uniprot_entry
Q3UGB2_MOUSE
resolver
uniprot_sec
B2RRH8
resolver
uniprot_sec
Q30BK8
resolver
uniprot_sec
Q6P288
resolver
amino_acid_sequence
MVGVPGAAAFQLGCEKRVPAMPGSPVEVKIQSRSSPPIMPPLPPINPGGPRPVSFTPTALSNGINHSPPTLNGAPSPPQRFSNGPASSTSSALTNQQLPATCGARQLSKLKRFLTTLQQFGNDISPEIGEKVRTLVLALVNSTVTIEEFHCKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARAAKQTPSQYLAQHEHLLLNTSIASPADSSELLMEVHGNGKRPSPERRDENNFERDTVPPEPPAKRVCTISPAPRHSPALTVPLMNPGGQFHPTPPPLQHYTLEDIATSHLYREPNKMLEHREVRERHHNLSLNGGYQDELVDHRLTEREWADEWKHLDHALNCIMEMVEKTRRSMAVLRRCQESDREELNYWKRRFNENTELRKTGTELVSRQHSPGSTDSLSNDSQREFTSRPATGYVPVEFWKKTEEAVNKVKIQAMSEVQKAVAEAEQKAFEVIATERARMEQTIADVKRQAAEDAFLVINEQEESTENCWNCGRKASETCSGCNIARYCGSFCQHKDWERHHRLCGQSLHGHSPHSQSRPLLPGGRGSARSADCSVPSPALDKTSATTSRSSTPASVTAIDANGL
uniprot
proteins
disease_involvement
DISEASE: Note=Required for tumorigenesis in a AOM/DSS colitis-associated carcinoma model. May be involved in intestinal tumorigenesis. {ECO:0000269|PubMed:21303973}.
uniprot
proteins
function
FUNCTION: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency. Involved in primordial germ cell (PCG) formation (PubMed:27281218). Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent mannerCan repress the expression of MMP7 in a ZBTB33-dependent manner (By similarity). Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (PubMed:19799863). Required for the maintenance of the secretory cell lineage in the small intestine (PubMed:16227606). Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (PubMed:25398765). {ECO:0000250|UniProtKB:O43439, ECO:0000269|PubMed:16227606, ECO:0000269|PubMed:25398765, ECO:0000269|PubMed:27281218}.
uniprot
proteins
mass_dalton
65904
uniprot
proteins
mutagenesis
MUTAGEN 105; /note="R->D: Disrupts interaction with PRDM14."; /evidence="ECO:0000269|PubMed:26523391"; MUTAGEN 109; /note="K->E: Disrupts interaction with PRDM14."; /evidence="ECO:0000269|PubMed:26523391"; MUTAGEN 330; /note="L->E: Reduces PRDM14 and OCT14 occupancy on target sites, no effect on interaction with PRDM14, predicted to impair homooligomerization; when associated with R-342; R-345; E-346; E-360; R-363 and R-374."; /evidence="ECO:0000269|PubMed:27281218"; MUTAGEN 342; /note="L->R: Reduces PRDM14 and OCT14 occupancy on target sites, no effect on interaction with PRDM14, predicted to impair homooligomerization; when associated with R-330; R-345; E-346; E-360; R-363 and R-374."; /evidence="ECO:0000269|PubMed:27281218"; MUTAGEN 345; /note="A->R: Reduces PRDM14 and OCT14 occupancy on target sites, no effect on interaction with PRDM14, predicted to impair homooligomerization; when associated with R-330; R-342; E-346; E-360; R-363 and R-374."; /evidence="ECO:0000269|PubMed:27281218"; MUTAGEN 346; /note="L->E: Reduces PRDM14 and OCT14 occupancy on target sites, no effect on interaction with PRDM14, predicted to impair homooligomerization; when associated with R-330; R-342; R-345; R-363 and R-374."; /evidence="ECO:0000269|PubMed:27281218"; MUTAGEN 360; /note="M->E: Reduces PRDM14 and OCT14 occupancy on target sites, no effect on interaction with PRDM14, predicted to impair homooligomerization; when associated with R-330; R-342; R-345; E-346; E-360; R-363 and R-374."; /evidence="ECO:0000269|PubMed:27281218"; MUTAGEN 363; /note="L->R: Reduces PRDM14 and OCT14 occupancy on target sites, no effect on interaction with PRDM14, predicted to impair homooligomerization; when associated with R-330; R-342; R-345; E-346; E-360 and R-374."; /evidence="ECO:0000269|PubMed:27281218"; MUTAGEN 374; /note="L->R: Reduces PRDM14 and OCT14 occupancy on target sites, no effect on interaction with PRDM14, predicted to impair homooligomerization; when associated with R-330; R-342; R-345; E-346; E-360 and R-363."; /evidence="ECO:0000269|PubMed:27281218
uniprot
proteins
protein_family
CBFA2T family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16227606
uniprot
proteins
pubmed
18039847
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19618476
uniprot
proteins
pubmed
19799863
uniprot
proteins
pubmed
21303973
uniprot
proteins
pubmed
25398765
uniprot
proteins
pubmed
26523391
uniprot
proteins
pubmed
27281218
uniprot
proteins
pubmed
9790752
uniprot
proteins
sequence_length
594
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00440}.
uniprot
proteins