Gemin6
entrez
67242
canonical
uniprot
Q9CX53
canonical
ensembl
ENSMUSG00000055760
resolver
ensp
ENSMUSP00000063554
resolver
ensp
ENSMUSP00000205925
resolver
enst
ENSMUST00000069486
resolver
genesymbol
Gemin6
resolver
uniprot
Q3TIW7
resolver
uniprot
Q9CQI0
resolver
uniprot
Q9CXC5
resolver
uniprot_entry
GEMI6_MOUSE
resolver
uniprot_sec
Q3TIW7
resolver
uniprot_sec
Q9CQI0
resolver
uniprot_sec
Q9CXC5
resolver
amino_acid_sequence
MSEWMKKSPLEWEDYVYKEVRVIACEKEYKGWLLTTDPVSANIVLVNFLEDGRLSVTGIMGHSVQTVETISEGDHRVREKLMHVFASGDCKGYSPEDLEEKRTSLKKWLEKNHIPVTEQGDAQRTLCVAGVLTIDPPYAPENCSSSNEIILSRIQDLIQGHLSASQ
uniprot
proteins
function
FUNCTION: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (By similarity). {ECO:0000250|UniProtKB:Q8WXD5}.
uniprot
proteins
mass_dalton
18750
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
166
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q8WXD5}. Nucleus, gem {ECO:0000250|UniProtKB:Q8WXD5}. Cytoplasm {ECO:0000250|UniProtKB:Q8WXD5}. Note=Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm (By similarity). {ECO:0000250}.
uniprot
proteins