Ndst1
entrez
15531
canonical
uniprot
Q3UHN9
canonical
ensembl
ENSMUSG00000054008
resolver
ensp
ENSMUSP00000126623
resolver
ensp
ENSMUSP00000158312
resolver
ensp
ENSMUSP00000276631
resolver
genesymbol
Ndst1
resolver
uniprot
O70353
resolver
uniprot
Q3TBX3
resolver
uniprot
Q3TDS3
resolver
uniprot
Q8BZE5
resolver
uniprot
Q9R206
resolver
uniprot_entry
NDST1_MOUSE
resolver
uniprot_sec
O70353
resolver
uniprot_sec
Q3TBX3
resolver
uniprot_sec
Q3TDS3
resolver
uniprot_sec
Q8BZE5
resolver
uniprot_sec
Q9R206
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by long N-sulfated sequences (6 or more sugar residues) in heparan sulfate, and heparin. {ECO:0000269|PubMed:12634318}.
uniprot
proteins
amino_acid_sequence
MPALACLRRLCRHLSPQAVLFLLFVFCLFSVFVSAYYLYGWNRGLEPSADASESDCGDPPPVAPSRLLPIKPVQAVAPSRTDPLVLVFVESLYSQLGQEVVAILESSRFKYRTEIAPGKGDMPTLTDKGRGRFALIIYENILKYVNLDAWNRELLDKYCVAYGVGIIGFFKANENSLLSAQLKGFPLFLHSNLGLKDCSINPKSPLLYVTRPSEVEKGVLPGEDWTVFQSNHSTYEPVLLAKTRSSESIPHLGADAGLHAALHATVVQDLGLHDGIQRVLFGNNLNFWLHKLVFVDAVAFLTGKRLSLPLDRYILVDIDDIFVGKEGTRMKVEDVKALFDTQNELRTHIPNFTFNLGYSGKFFHTGTDAEDAGDDLLLSYVKEFWWFPHMWSHMQPHLFHNQSVLAEQMALNKKFAVEHGIPTDMGYAVAPHHSGVYPVHVQLYEAWKQVWGIRVTSTEEYPHLKPARYRRGFIHNGIMVLPRQTCGLFTHTIFYNEYPGGSSELDKIINGGELFLTVLLNPISIFMTHLSNYGNDRLGLYTFKHLVRFLHSWTNLRLQTLPPVQLAQKYFQIFSEEKDPLWQDPCEDKRHKDIWSKEKTCDRFPKLLIIGPQKTGTTALYLFLGMHPDLSSNYPSSETFEEIQFFNGHNYHKGIDWYMEFFPIPSNTTSDFYFEKSANYFDSEVAPRRAAALLPKAKILSILINPADRAYSWYQHQRAHDDPVALKYTFHEVITAGPDASSKLRALQNRCLVPGWYATHIERWLSAFHANQILVLDGKLLRTEPAKVMDTVQKFLGVTSTVDYHKTLAFDPKKGFWCQLLEGGKTKCLGKSKGRKYPEMDLDSRAFLKDYFRDHNIELSKLLYKMGQTLPTWLREDLQNTR
uniprot
proteins
ec_number
2.8.2.8
uniprot
proteins
ec_number
3.5.1.-
uniprot
proteins
function
FUNCTION: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate (PubMed:10664446, PubMed:10758005, PubMed:11087757, PubMed:12590599, PubMed:12692154, PubMed:16020517, PubMed:16056228, PubMed:18337501). Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis (Probable). Plays a role in determining the extent and pattern of sulfation of heparan sulfate (Probable). Participates in biosynthesis of heparan sulfate that can ultimately serve as L-selectin ligands, thereby playing a role in inflammatory response (PubMed:16056228). Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). {ECO:0000250|UniProtKB:P52848, ECO:0000269|PubMed:10664446, ECO:0000269|PubMed:10758005, ECO:0000269|PubMed:11087757, ECO:0000269|PubMed:12590599, ECO:0000269|PubMed:12692154, ECO:0000269|PubMed:16020517, ECO:0000269|PubMed:16056228, ECO:0000269|PubMed:18337501, ECO:0000305|PubMed:12634318}.
uniprot
proteins
mass_dalton
100726
uniprot
proteins
mutagenesis
MUTAGEN 486; /note="C->W: Loss of deacetylase activity. No effect on sulfotransferase activity."; /evidence="ECO:0000269|PubMed:12590599"; MUTAGEN 614; /note="K->A: No effect on deacetylase activity. Loss of sulfotransferase activity."; /evidence="ECO:0000269|PubMed:12590599
uniprot
proteins
pathway_participation
PATHWAY: Glycan metabolism; heparan sulfate biosynthesis. {ECO:0000269|PubMed:10758005, ECO:0000269|PubMed:12590599, ECO:0000269|PubMed:12634318, ECO:0000269|PubMed:16020517, ECO:0000269|PubMed:16056228}.; PATHWAY: Glycan metabolism; heparin biosynthesis. {ECO:0000305|PubMed:12634318}.
uniprot
proteins
protein_family
NDST subfamily
uniprot
proteins
protein_family
Sulfotransferase 1 family
uniprot
proteins
pubmed
10664446
uniprot
proteins
pubmed
10758005
uniprot
proteins
pubmed
10852901
uniprot
proteins
pubmed
11087757
uniprot
proteins
pubmed
12590599
uniprot
proteins
pubmed
12634318
uniprot
proteins
pubmed
12692154
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16020517
uniprot
proteins
pubmed
16056228
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18337501
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9565617
uniprot
proteins
sequence_length
882
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q02353}; Single-pass type II membrane protein {ECO:0000255}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P52848}; Single-pass type II membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:P52848}; Single-pass type II membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 18..38; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins