CNTF
entrez
1270
canonical
uniprot
P26441
canonical
ensembl
ENSG00000242689
resolver
ensp
ENSP00000355370
resolver
enst
ENST00000361987
resolver
genesymbol
CNTF
resolver
hgnc
HGNC:2169
resolver
uniprot
B2RAB2
resolver
uniprot_entry
CNTF_HUMAN
resolver
uniprot_sec
B2RAB2
resolver
amino_acid_sequence
MAFTEHSPLTPHRRDLCSRSIWLARKIRSDLTALTESYVKHQGLNKNINLDSADGMPVASTDQWSELTEAERLQENLQAYRTFHVLLARLLEDQQVHFTPTEGDFHQAIHTLLLQVAAFAYQIEELMILLEYKIPRNEADGMPINVGDGGLFEKKLWGLKVLQELSQWTVRSIHDLRFISSHQTGIPARGSHYIANNKKM
uniprot
proteins
function
FUNCTION: Functions as a cytokine through the ciliary neurotrophic factor receptor (CNTFR) complex (PubMed:10966616, PubMed:11285233, PubMed:11294841, PubMed:31932351, PubMed:36930708). The CNTFR complex indeed consists of the membrane-anchored non-signaling receptor CNTFR and the two signaling receptor subunits IL6ST/gp130 and LIFR that transduce the signal into the cell (PubMed:36930708). Functionally, promotes neuronal survival, supports differentiation of various neuronal and non-neuronal cells, and importantly regulates oligodendrocyte progenitor proliferation (PubMed:1861138, PubMed:1883844, PubMed:31932351). Mechanistically, ligand binding to the CNTFR induces dimerization of the IL6ST/gp130 and LIFR, which activates JAK tyrosine kinases (JAK1 or JAK2 and to lesser extent TYK2) bound to their intracellular domains (PubMed:11294841). These kinases subsequently phosphorylate IL6ST/gp130 and LIFR (PubMed:11294841). The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducer and activators of transcription (STAT3 and to lesser extent STAT1) (PubMed:11285233, PubMed:11294841). Can also signal via trans-signaling using soluble forms of CNTFR (PubMed:31932351, PubMed:7681218). Seems to prevent the degeneration of motor axons after axotomy (By similarity). {ECO:0000250|UniProtKB:P20294, ECO:0000269|PubMed:10966616, ECO:0000269|PubMed:11285233, ECO:0000269|PubMed:11294841, ECO:0000269|PubMed:1861138, ECO:0000269|PubMed:1883844, ECO:0000269|PubMed:31932351, ECO:0000269|PubMed:36930708, ECO:0000269|PubMed:7681218}.
uniprot
proteins
mass_dalton
22931
uniprot
proteins
protein_family
CNTF family
uniprot
proteins
pubmed
10391209
uniprot
proteins
pubmed
10966616
uniprot
proteins
pubmed
11285233
uniprot
proteins
pubmed
11294841
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1840538
uniprot
proteins
pubmed
1861138
uniprot
proteins
pubmed
1883844
uniprot
proteins
pubmed
1915374
uniprot
proteins
pubmed
31932351
uniprot
proteins
pubmed
36930708
uniprot
proteins
pubmed
7681218
uniprot
proteins
pubmed
7796798
uniprot
proteins
pubmed
8075647
uniprot
proteins
sequence_length
200
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:1915374}. Secreted {ECO:0000250|UniProtKB:Q02011}. Note=The precursor semms to be cytoplasmic (Probable). The lack of a specific hydrophobic segment in the precursor sequence suggests that CNTF is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins (By similarity). {ECO:0000250|UniProtKB:P20294, ECO:0000305|PubMed:1915374}.
uniprot
proteins