Actl6b
entrez
83766
canonical
uniprot
Q99MR0
canonical
ensembl
ENSMUSG00000029712
resolver
ensp
ENSMUSP00000119356
resolver
ensp
ENSMUSP00000311504
resolver
ensp
ENSMUSP00000311505
resolver
ensp
ENSMUSP00000311513
resolver
enst
ENSMUST00000139395
resolver
genesymbol
Actl6b
resolver
genesymbol_syn
Actl6
resolver
genesymbol_syn
Arpna
resolver
genesymbol_syn
Baf53b
resolver
uniprot
Q54A88
resolver
uniprot_entry
ACL6B_MOUSE
resolver
uniprot_sec
Q54A88
resolver
amino_acid_sequence
MSGGVYGGDEVGALVFDIGSFSVRAGYAGEDCPKADFPTTVGLLAAEEGGGLELEGEKEKKGKIFHIDTNALHVPRDGAEVMSPLKNGMIEDWECFRAILDHTYSKHVKSEPNLHPVLMSEAPWNTRAKREKLTELMFEQYNIPAFFLCKTAVLTAFANGRSTGLVLDSGATHTTAIPVHDGYVLQQGIVKSPLAGDFISMQCRELFQEMAIDIIPPYMIAAKEPVREGAPPNWKKKEKLPQVSKSWHNYMCNEVIQDFQASVLQVSDSPYDEQVAAQMPTVHYEMPNGYNTDYGAERLRIPEGLFDPSNVKGLSGNTMLGVGHVVTTSIGMCDIDIRPGLYGSVIVTGGNTLLQGFTDRLNRELSQKTPPSMRLKLIASNSTMERKFSPWIGGSILASLGTFQQMWISKQEYEEGGKQCVERKCP
uniprot
proteins
function
FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth. Essential for neuronal maturation and dendrite development (By similarity). {ECO:0000250|UniProtKB:O94805, ECO:0000269|PubMed:12368262, ECO:0000269|PubMed:17640523, ECO:0000269|PubMed:17920018}.
uniprot
proteins
mass_dalton
46891
uniprot
proteins
protein_family
Actin family
uniprot
proteins
pubmed
11239002
uniprot
proteins
pubmed
12368262
uniprot
proteins
pubmed
12437990
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17640523
uniprot
proteins
pubmed
17920018
uniprot
proteins
pubmed
22952240
uniprot
proteins
pubmed
26601204
uniprot
proteins
sequence_length
426
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12437990}.
uniprot
proteins