CD22
entrez
933
canonical
uniprot
P20273
canonical
ensembl
ENSG00000012124
resolver
ensp
ENSP00000085219
resolver
ensp
ENSP00000339349
resolver
ensp
ENSP00000403822
resolver
ensp
ENSP00000441237
resolver
ensp
ENSP00000442279
resolver
genesymbol
CD22
resolver
genesymbol_syn
SIGLEC2
resolver
hgnc
HGNC:1643
resolver
uniprot
F5GYU4
resolver
uniprot
F5H7U3
resolver
uniprot
O95699
resolver
uniprot
O95701
resolver
uniprot
O95702
resolver
uniprot
O95703
resolver
uniprot
Q01665
resolver
uniprot
Q0EAF5
resolver
uniprot
Q32M46
resolver
uniprot
Q92872
resolver
uniprot
Q92873
resolver
uniprot
Q9UQA6
resolver
uniprot
Q9UQA7
resolver
uniprot
Q9UQA8
resolver
uniprot
Q9UQA9
resolver
uniprot
Q9UQB0
resolver
uniprot
Q9Y2A6
resolver
uniprot_entry
CD22_HUMAN
resolver
uniprot_entry
Q0EAF5_HUMAN
resolver
uniprot_sec
F5GYU4
resolver
uniprot_sec
F5H7U3
resolver
uniprot_sec
O95699
resolver
uniprot_sec
O95701
resolver
uniprot_sec
O95702
resolver
uniprot_sec
O95703
resolver
uniprot_sec
Q01665
resolver
uniprot_sec
Q32M46
resolver
uniprot_sec
Q92872
resolver
uniprot_sec
Q92873
resolver
uniprot_sec
Q9UQA6
resolver
uniprot_sec
Q9UQA7
resolver
uniprot_sec
Q9UQA8
resolver
uniprot_sec
Q9UQA9
resolver
uniprot_sec
Q9UQB0
resolver
uniprot_sec
Q9Y2A6
resolver
amino_acid_sequence
MHLLGPWLLLLVLEYLAFSDSSKWVFEHPETLYAWEGACVWIPCTYRALDGDLESFILFHNPEYNKNTSKFDGTRLYESTKDGKVPSEQKRVQFLGDKNKNCTLSIHPVHLNDSGQLGLRMESKTEKWMERIHLNVSERPFPPHIQLPPEIQESQEVTLTCLLNFSCYGYPIQLQWLLEGVPMRQAAVTSTSLTIKSVFTRSELKFSPQWSHHGKIVTCQLQDADGKFLSNDTVQLNVKHTPKLEIKVTPSDAIVREGDSVTMTCEVSSSNPEYTTVSWLKDGTSLKKQNTFTLNLREVTKDQSGKYCCQVSNDVGPGRSEEVFLQVQYAPEPSTVQILHSPAVEGSQVEFLCMSLANPLPTNYTWYHNGKEMQGRTEEKVHIPKILPWHAGTYSCVAENILGTGQRGPGAELDVQYPPKKVTTVIQNPMPIREGDTVTLSCNYNSSNPSVTRYEWKPHGAWEEPSLGVLKIQNVGWDNTTIACAACNSWCSWASPVALNVQYAPRDVRVRKIKPLSEIHSGNSVSLQCDFSSSHPKEVQFFWEKNGRLLGKESQLNFDSISPEDAGSYSCWVNNSIGQTASKAWTLEVLYAPRRLRVSMSPGDQVMEGKSATLTCESDANPPVSHYTWFDWNNQSLPYHSQKLRLEPVKVQHSGAYWCQGTNSVGKGRSPLSTLTVYYSPETIGRRVAVGLGSCLAILILAICGLKLQRRWKRTQSQQGLQENSSGQSFFVRNKKVRRAPLSEGPHSLGCYNPMMEDGISYTTLRFPEMNIPRTGDAESSEMQRPPPDCDDTVTYSALHKRQVGDYENVIPDFPEDEGIHYSELIQFGVGERPQAQENVDYVILKH
uniprot
proteins
function
FUNCTION: Most highly expressed siglec (sialic acid-binding immunoglobulin-like lectin) on B-cells that plays a role in various aspects of B-cell biology including differentiation, antigen presentation, and trafficking to bone marrow (PubMed:34330755, PubMed:8627166). Binds to alpha 2,6-linked sialic acid residues of surface molecules such as CD22 itself, CD45 and IgM in a cis configuration. Can also bind to ligands on other cells as an adhesion molecule in a trans configuration (PubMed:20172905). Acts as an inhibitory coreceptor on the surface of B-cells and inhibits B-cell receptor induced signaling, characterized by inhibition of the calcium mobilization and cellular activation. Mechanistically, the immunoreceptor tyrosine-based inhibitory motif domain is phosphorylated by the Src kinase LYN, which in turn leads to the recruitment of the protein tyrosine phosphatase 1/PTPN6, leading to the negative regulation of BCR signaling (PubMed:8627166). If this negative signaling from is of sufficient strength, apoptosis of the B-cell can be induced (PubMed:20516366). {ECO:0000269|PubMed:20172905, ECO:0000269|PubMed:20516366, ECO:0000269|PubMed:34330755, ECO:0000269|PubMed:8627166}.
uniprot
proteins
mass_dalton
95348
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Tyr-762, Tyr-807 and Tyr-822 are involved in binding to SYK, GRB2 and SYK, respectively. Phosphorylation of Tyr-842 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2. {ECO:0000250|UniProtKB:P35329}.; PTM: Phosphorylated on tyrosine residues by LYN. {ECO:0000250|UniProtKB:P35329}.
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
protein_family
SIGLEC (sialic acid binding Ig-like lectin) family
uniprot
proteins
pubmed
10079291
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1691828
uniprot
proteins
pubmed
1985119
uniprot
proteins
pubmed
20172905
uniprot
proteins
pubmed
20516366
uniprot
proteins
pubmed
34273351
uniprot
proteins
pubmed
34330755
uniprot
proteins
pubmed
7618087
uniprot
proteins
pubmed
8463235
uniprot
proteins
pubmed
8496602
uniprot
proteins
pubmed
8627166
uniprot
proteins
pubmed
8647200
uniprot
proteins
pubmed
9143697
uniprot
proteins
sequence_length
847
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20172905}; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 688..706; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins