TIPRL
entrez
261726
canonical
uniprot
O75663
canonical
ensembl
ENSG00000143155
resolver
ensp
ENSP00000356804
resolver
ensp
ENSP00000356807
resolver
genesymbol
TIPRL
resolver
hgnc
HGNC:30231
resolver
uniprot
B2R8V3
resolver
uniprot
Q5HYB2
resolver
uniprot
Q8IZ86
resolver
uniprot_entry
TIPRL_HUMAN
resolver
uniprot_sec
B2R8V3
resolver
uniprot_sec
Q5HYB2
resolver
uniprot_sec
Q8IZ86
resolver
amino_acid_sequence
MMIHGFQSSHRDFCFGPWKLTASKTHIMKSADVEKLADELHMPSLPEMMFGDNVLRIQHGSGFGIEFNATDALRCVNNYQGMLKVACAEEWQESRTEGEHSKEVIKPYDWTYTTDYKGTLLGESLKLKVVPTTDHIDTEKLKAREQIKFFEEVLLFEDELHDHGVSSLSVKIRVMPSSFFLLLRFFLRIDGVLIRMNDTRLYHEADKTYMLREYTSRESKISSLMHVPPSLFTEPNEISQYLPIKEAVCEKLIFPERIDPNPADSQKSTQVE
uniprot
proteins
function
FUNCTION: May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as a negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair. {ECO:0000269|PubMed:17384681, ECO:0000269|PubMed:26717153}.
uniprot
proteins
mass_dalton
31444
uniprot
proteins
mutagenesis
MUTAGEN 71; /note="D->L: Abolishes interaction with PPP2CA, PPP2CB and PPP4C."; /evidence="ECO:0000269|PubMed:17944932"; MUTAGEN 79; /note="Y->H: Diminishes interaction with PPP2CA."; /evidence="ECO:0000269|PubMed:17944932"; MUTAGEN 136; /note="I->T: Abolishes interaction with PPP2CA, PPP2CB and PPP4C."; /evidence="ECO:0000269|PubMed:17944932"; MUTAGEN 196; /note="M->V: Abolishes interaction with PPP2CA, PPP2CB and PPP4C."; /evidence="ECO:0000269|PubMed:17944932"; MUTAGEN 198; /note="D->N: Abolishes interaction with PPP2CA, PPP2CB and PPP4C."; /evidence="ECO:0000269|PubMed:17944932
uniprot
proteins
protein_family
TIP41 family
uniprot
proteins
pubmed
12761501
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16085932
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17384681
uniprot
proteins
pubmed
17944932
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26717153
uniprot
proteins
pubmed
27489114
uniprot
proteins
sequence_length
272
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17944932}.
uniprot
proteins