Hydin
entrez
244653
canonical
uniprot
Q80W93
canonical
ensembl
ENSMUSG00000059854
resolver
ensp
ENSMUSP00000046204
resolver
genesymbol
Hydin
resolver
genesymbol_syn
Hy3
resolver
uniprot
Q3UQ06
resolver
uniprot
Q68ED1
resolver
uniprot
Q8BRL9
resolver
uniprot
Q8CDF4
resolver
uniprot_entry
HYDIN_MOUSE
resolver
uniprot_sec
Q3UQ06
resolver
uniprot_sec
Q68ED1
resolver
uniprot_sec
Q8BRL9
resolver
uniprot_sec
Q8CDF4
resolver
amino_acid_sequence
MTLKIKCVANYIKEKIPNVLFLCDPEARLQQLTASVPLCEQRKYFKQTNKRLEESMGAMHRKMAKVISGLQSKVLPPMSPKVVTEEEVNRMLTPSEFLKEMSLTTEQKLASTRIICRPQITELLDMGETTHQKFSRVDLDQALFQPFPSEIIFQNYSPCEVYEVPLVLRNNDKIPRMVKVVEESSPYFKIISPKDIGHKVAPGVPSVFRILFTPEENKDYAHMLTCITEREKFIVPVKARGARAILDFPDELNFSTCPVKYNTQKVLLVRNIGNKDSMFHLKTRSPYSVEPTGGILNVGESMQLEVDFEPQTVGSHDGKLIVTYDTGEMVFVCLYGVAIDVNIRLDKNSLIMEKTYISLANQRSITIHNRTNIIAHFQWKVFATEEEEDKEKYKICDGLNKEEKQETSMILEDSVLDPSLRERLSIISRTFENQRKLVQGDSMLFLDHVFTIEPPEGDVWPNSSAEITVYFNPLEAKLYQQTVYCDISGREIRLPLRIRGEGMGPKLHFNFELLDIGKVFIGSAHCYEAILSNKGSIDALFNVIPPTSALGACFVFNPKEGIIEPSGVQAVQISFSSTILGYFEEEFLIDVNGSPEPVKMTIRGCVIGPTFHFNVPALNFGNVSYGFPHTLMCSLNNTSLVPMTFKLRVRGDGEGMSSIPSYSQESDSKQWSGINTEMPTTKPKEFTISPNSGTIRAQGFTAIKVTLCSNTVQKYELALVVDVEGIGEEVLALLITARCVVPKLQLVTTEVDFGRCFLKYPYEKTIQLVNHDDLPGCYKVLPQLYENSPPVLLSSPSPCGVISPHSTVSIPLALETQVIGAHRSIVYISVFGSQEAPLACNIQSIGEGPVIFIHPTQIDFGNIYVLKDTSRILQLSNQSFIPAVFRVRMANKKSLWTVKPSEGAVPAEDDIPLTLTANLDDIVTFKDTVILEIKHSNTYRIPIQATGIGSTIVSDKPFAPELNLGAHFSLDTHYYRFKLTNKGRRVQQLFWMNDDFRPKEKQSKKEPGKKGSTSSSRRQSKASQEPTDNGNPVFQLYPVRMELYPGQTIDVILEGYSATPKKVKEKLVCQAIVGTQKGKSLLMSVNIICEFIAPIIQLSAKQLLYRLEKKPNSNLESDYQSLVIKNITTLPVNMLLSTTRPFFICETDKSLLPATPKPIKLEVDEEKHLLIKFDPSYRNDLNNWVAEEVLSIKYLEHPQVDNLGLRAEVHYPNLSFEVMDIDFGCILNDTEVIRYIMITNCSPLVVKFRWFFLVDEEENQIRFAPCMKPYSAFLSQMESIAATSVTASSLAAPHTVEYTEMDFSDSIKTILMDDEAGPEEIKKPATSTMVSEAIKYSSAGTERSQSQPDYPECMWIYEQDEMLSIGIEEVFDILPLYGVLRPYSSHQISFTFYGHCDIIARAKALCEVEGGPTYEVLLKGEASLVNYSFDTKDINYGLQLFDHVTEREITLKNTGKVGFEFNVLSNYRSSQRNLLPGVPLILPLSGFIQSNKEQVLKVYYLPGIPEVFQRNFQIQIAHLVPENITLYGEGIFPRISLDLHRNLQGNEKYEHFLEQAKKNVEKEYTKYEAVDQYEVMAEELPEEETAEISAHVQMEVERLIVQDYALEHQRSISNNTEDIYFSQRSCRKLTKVQLPEYILDFGYIVLGDVRTHIVKITNTSHFPVSFHAEKQVLHETGFSTELDRVKNLPYYETETFEVRCDPQGANLPVGNKEVILPIKVYGGPTIHLCLQATVIIPSMTLSCNKIEFATIQCGQCMVETIQLSNHLQVPCEWFVHTPKSTNKLDKHMPKYLRRKLQAEMIPKSRIFEIQPTSGILDPGERANVQVKFMPKEEKLYSQSLLFQIGQSSQKLTLLAQGQGLEPRLEFSPSVLELGPLLPFASGDEAEVIVRNPCNFPIEFYSLEFDQQYLLEEKMLRQLKGYDSYNTLLLPPRNPGEKLPPEVYDYFKEMKKSKEEHMKAKYMENLENEEEEMNTSDQGTTSTKRTSISRGISVTSNLEERHLTIEAKNYLDEDDYEESLEKLTFQTDKMQSTDSHSVEEVGEVESNPVSKAIARHLGIDISAEGRLAKNRKGIAIIVHGTPLSGKTANAISMAKFYNAACLNIDSIVLEALSDTNNILGIRARELCIRAAIEQSMREAEESAHESSMTQNTVVPARLSTENLGRFTSELTLITQEYKVPKTVRGSVMLPKGKADSHFTGSQKQHHQHQSETPQVQISSSPLLPGPTHRRLSVSASIGGETGLMSCVLPDDLLIQILAERIQLSNCFRGVVFDGLDTLFARNAPSALHCLLKAIGSREHIYVINMSQDYVVMKAQEKAKKEQEENKRKEALAKEKERLQTLDEDEYDALTAEEKVAFDRDVRQALRERKKRELERLAKEMQEKKLQQELERQKEEDELKRKVKRPKAGPAAKEEPPLKKAQGATNKQLAAVAKIELKMESIERKVSVREHATLEETTRKKKAMTEYPLLIPISQEQEDSEGDFLKDSDKNLAQKFKIYDMCLKDVQNILMYWDRKQGMMVPHTGTDEMSHEADDQRQAPSGGGGRKGRKDRERERLEKERAEKERLEREKAERERLEKLKALEERSDVEGEGEEEHEGKKDLGVPFINIQSPDFEGVSWKQALESDKLPKGDQILDILGLGSSGPPIPPPVLFSIISYPAKRQSLVATEILKHFVFVIPPNDDIPLMDEKKDPEGDSDIFLNTIITKAQEEQPSPPKGSKQKLKDKPEQVRETQKEKRRTYSSRKGLPGGTSGSIVPMSDIDQNSFDGEHSQEKFIRLNHFRWIVPPNGEVTLRVHFSSLDVGNYDQTFNFELLGTRRQYQLYCRGVCTYPYICRDPKVVFSQRKKDMKLKEVVVKKYVVSMEKFYFGPLLCGKSRDKYKSSLFPGNMETLTILNDSPMVVEAYFCFQHDIKASTYFLEPVNMTLKPNEKQALNVWAYPTAVGIFEDSIVCCIKENPEPAIFKLSCQGIRPEIEVEPRQLHFDRLLLHRKETKIVILRNVTPLPVAWRISNLEHLGEDFTVSMMQGTMLPKGEYGLQVHFQPSKPVNIKKAIRIEVLDAENLVGVVQIENILIFAESYDIALDITFPKGAEGGLDFGTLRVMEEVKQTLQLKNRGKYEIIFSFTVDTLGVLPTNLSSMISVQPKRGTLASIDKPTTVQVFFRARKEVKIDCQPILRCQIIEPTLPEGEIIASIPIKFSVNAVYSKFTISPSSIINFGALICGTRKSITFTIENQGIIDFKYALYRLTGESPILQKKITSHMRHGRTRESESFYKPGATKMAKFSDTVQKDTNIANQARFTHGMFTVYPGFGSIPSGGQQVITIECFADPVGRCEEFLAIDISDRDPRENPAGIPYTLLAEACLPAFVTDNNILIFEEHQICTSPNLYHILQTIQSGGLFVEDENKFIFCNVLVGHQAKARFKISNVGKISCDINIVIKPISNKPANRITDTFDVEPSKMCIGSRSHAFVTVLFTPQTMQTYQCIFEATLDGLPSNIARSRGLVFDIVGEGTLPRVTVIRPTLYNQHGNPLLLFKRLLLGHSEKLPLILKNNGTIPAQLHVDLRDQLGVFSLKGRPTTSYIYIMEENKPNEKVKKAHTASLVVSPGDTAEFDVFFHSNKIGRMTGTIHLSVINNQYEETMIHLVGESYEDDITLDNIHGLISSTSQESSDKSEVIEIAEESTMEDLVTAALMEHIQFGYCHIGISYNVSFTITNHSQVNVIRFEWPLLATLSFSPQIGHLHPGCSKDVVVTLKSESPITLKKMCVKCKLSKIMFQLPVDQVPDWDDRMRTVKWVDAPRNTPLTLNTKRKVIEMDPEPAHSVVEENYRELRIQFSANVDFASYQCETTEVFFKETLVYQTRVFEFDLVNTGQVLLEFCWISEEASKAVSFAMPERQGSSQKELSQGSGSSLDSALDRWTEASPSPFSVEPPSGVVPVGKTQKLKVKFSPMDIGEFESSLYCQIPNLPLGEQGPILITKGRSVLPFCHFDLKESDYISGHRRNPELRGPGAGPLEPNTRVIEFTSVGIGGKNVQTFTILNPTNSTYSFCWTSEETESLQHPPAFVCLTEKGIIHPEKKAEIIFQFLPAHLDITEEFWTFSIPEHNISVPFLLVGKTTDPLISLDKSHLNFSSLLIGREARETVKIINKEEQGFNFAFQDNSRYSEGFNNSLIVCPMEGWIPPLSRFPVDIFFTPKQEGDVNFNLICNIKKKAHPLTLNVKAEGYTMNAEVKCRDRMGTTILLTSTQVNTINFYEVELNECVQCEFSFINTGKFNFSYQAELSGPKLLLQYLDFTPTDSSVDVGQSEPANLSFQPYQKCVLKGLELKIKISHGPTFVCNILGCAVSPAVHFSFTSHNFGTCFIYQAGMPPYKQILVVTNKEETSMSLDCLYTNTPHIEVNFNVDVIKPGKTLEIPITFYPREAISYRELIPFEINGLSQQTVEIKGKGTEMKLLVLDPANRIVKLGAVLPGQVVRKTVSLVNNSLAQLTFNHSVLFSIPELQEAKVITLEPFHTITMKPKEVCKLEITFAPKKRVPPFSEEVFMEWMGLLRPLFLLSGCCQALEISLDQEHLPFGPVVYQTQATRRILIMNTGDVGARFKWDVKKLKPHFSISPEEGYIISGTEVALEVTYHPTEIGKESLYKNILCFIQGGNPLCLTLSGTCVGPPVVKEVVNFNCQVRSRHTQTILLSNRSNQTWNLHPIFEGEHWEGPEFITLEAHQQNKPYEITYKPRTMNLENRKHQGTLFFPLPDGTGWLYALHGTAELPKAVANIYREVPCKTPYTELLPISNWLNKPQRFRVIVEILKPEKTDLSVTLKGLDYIDVLSGSKKDYKLNFFSYKEGLYTAKVIFRNEVTNEFLYYTVSFRVTPSGIIKTIQMTSPVRQSVSASIKLENPLPYSVTFSTECKLSDISLPSQFAVPPNSEGTFSFEFQPLKAGELCGRLTLHNSDLGYYQYELALKALPAPPEKPVHFQTVLGSSQSILAKFTNYTRLKTEYYCKTDCSDFHTEKVINAAPGAQGGTEVSVEVFFEPSHLGETKGILCLSSLIGGEYIIPLFGIALPPKPQGPFLIRAGYNIIIPFKNVFLHATSFSFIVENPAFSIRAAETVRPKKINNITVYFEGNPSGSKTPITSKLIVTCPQCEGTESGIKWVYYLKGITP
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Hydin are the cause of spontaneous hydrocephalus 3, a lethal communicating hydrocephalus with perinatal onset. There is lethality in the first weeks of life because of hydrocephalus caused by abnormal ependymal ciliary motility. Cilia are unable to bend normally, ciliary beat frequency is reduced, and the cilia tend to stall. As a result, these cilia are incapable of generating fluid flow. Similar defects are observed for cilia in trachea. Mice do not exhibit randomization of left-right body asymmetry or situs inversus. {ECO:0000269|PubMed:12719380, ECO:0000269|PubMed:18250199}.
uniprot
proteins
function
FUNCTION: Required for ciliary motility (PubMed:18250199). Required for localization of SPEF2 to the ciliary axoneme in ciliated respiratory epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q4G0P3, ECO:0000269|PubMed:18250199}.
uniprot
proteins
mass_dalton
581523
uniprot
proteins
pubmed
12719380
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17296793
uniprot
proteins
pubmed
18250199
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30535028
uniprot
proteins
pubmed
32072696
uniprot
proteins
sequence_length
5154
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000305}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:30535028}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q4G0P3}. Note=Localizes in the cilium axoneme in a SPEF1-dependent manner. {ECO:0000269|PubMed:30535028}.
uniprot
proteins