SPX
entrez
691138
canonical
uniprot
M0R8L2
canonical
ensembl
ENSRNOG00000053700
resolver
ensembl
ENSRNOG00055009997
resolver
ensembl
ENSRNOG00060009139
resolver
ensembl
ENSRNOG00065005783
resolver
ensp
ENSRNOP00000071461
resolver
genesymbol
SPX
resolver
uniprot
Q6TXE0
resolver
uniprot_entry
SPXN_RAT
resolver
uniprot_sec
Q6TXE0
resolver
amino_acid_sequence
MKGPSILAVAALALLLVLSVLENSSGAPQRLSEKRNWTPQAMLYLKGAQGHRFISDQSRRKELADRPPPERRNPNLQLLTLPEAAALFLASLEKPQKDEGGDFDKSKLLEDRRFYW
uniprot
proteins
function
FUNCTION: Plays a role as a central modulator of cardiovascular and renal function and nociception. Also plays a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (PubMed:20045034, PubMed:22038051). {ECO:0000269|PubMed:20045034, ECO:0000269|PubMed:22038051}.; FUNCTION: [Spexin-1]: Acts as a ligand for galanin receptors GALR2 and GALR3 (By similarity). Intracerebroventricular administration of the peptide induces an increase in arterial blood pressure, a decrease in both heart rate and renal excretion and delayed natriuresis. Intraventricular administration of the peptide induces antinociceptive activity. Intraperitoneal administration of the peptide induces a reduction in food consumption and body weight. Inhibits long chain fatty acid uptake into adipocytes. Also induces contraction of muscarinic-like stomach smooth muscles (PubMed:24550067). {ECO:0000250, ECO:0000269|PubMed:24550067}.; FUNCTION: [Spexin-2]: Intracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate. Intraventricular administration of the peptide induces antinociceptive activity (PubMed:22038051). {ECO:0000269|PubMed:22038051}.
uniprot
proteins
mass_dalton
13083
uniprot
proteins
protein_family
Spexin family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
19132080
uniprot
proteins
pubmed
20045034
uniprot
proteins
pubmed
20530460
uniprot
proteins
pubmed
22038051
uniprot
proteins
pubmed
23080164
uniprot
proteins
pubmed
24550067
uniprot
proteins
sequence_length
116
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Secreted, extracellular space {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Note=Secreted via the classical ER/Golgi-dependent pathway into the extracellular medium largely as a full-length protein without the signal peptide, and not as a hydrolyzed and amidated peptide. Localized extracellularly surrounding the villous trophoblastic cells. Detected in the serum (By similarity). {ECO:0000250}.
uniprot
proteins