Slc15a4
entrez
246280
canonical
uniprot
O09014
canonical
ensembl
ENSRNOG00000000962
resolver
ensembl
ENSRNOG00055013455
resolver
ensembl
ENSRNOG00060001642
resolver
ensembl
ENSRNOG00065001668
resolver
ensp
ENSRNOP00000001277
resolver
ensp
ENSRNOP00055018697
resolver
ensp
ENSRNOP00060001605
resolver
ensp
ENSRNOP00065001566
resolver
enst
ENSRNOT00055023054
resolver
enst
ENSRNOT00060002481
resolver
enst
ENSRNOT00065002236
resolver
genesymbol
Slc15a4
resolver
genesymbol_syn
Pht1
resolver
uniprot
Q5M931
resolver
uniprot_entry
S15A4_RAT
resolver
uniprot_sec
Q5M931
resolver
amino_acid_sequence
MEGERAPLLGSRRAAAAAGVFAGRRAACGAVLLAELLERAAFYGVTANLVLFLNGAPFNWEGAQASQALLLFMGLTYLGSPFGGWLADARLGRARAILLSLALYLLGMLAFPLLAAPRSRSFLCGDPHPELVRNCSAPFPNGTAVCPDAAARRCAPATFAGLVLVGLGVATVKANITPFGADQVKDRGPEATRRFFNWFYWSINLGAILSLGGIAYIQQNVSFLTGYLIPTVCVAIAFLVFLCGQSVFITKPPDGSAFTDMFRILTYSCCSQRGGQRRSGEGLGVFQQSSKHSLFDSCKMSRGGPFTEDKVEDVKALVKIVPVFLALIPYWTVYFQMQTTYVLQSLHLKIPEISSITTTHHTLPAAWLTMFDAVLILLLIPLKDKLVDPVLRRHGLLPSSLKRIAVGMFFVTCSAFAAGILESKRLDLVKEKTINQTIGGVVYHAADLPIWWQIPQYVLIGISEIFASIAGLEFAYSAAPKSMQSAIMGLFFFFSGIGSFVGSGLLALVSLKAIGWMSSHTDFGNINSCHLHYYFFLLAAIQGATLLLFLIVSVKYDRQRARTDGGTASTRT
uniprot
proteins
function
FUNCTION: Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response (PubMed:9092568). Preferably binds to short peptides with a basic residue at the first position and a hydrophobic residue at the second position (By similarity). Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans (By similarity). Transporter activity is pH-dependent and maximized in the acidic lysosomal environment (PubMed:9092568). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand, and L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (tri-DAP), the NOD1 ligand. Required for TLR7, TLR8 and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs). Independently of its transporter activity, also promotes the recruitment of innate immune adapter TASL to endolysosome downstream of TLR7, TLR8 and TLR9: TASL recruitment leads to the specific recruitment and activation of IRF5 (By similarity). Required for isotype class switch recombination to IgG2c isotype in response to TLR9 stimulation. Required for mast cell secretory-granule homeostasis by limiting mast cell functions and inflammatory responses (By similarity). {ECO:0000250|UniProtKB:Q8N697, ECO:0000250|UniProtKB:Q91W98, ECO:0000269|PubMed:9092568}.
uniprot
proteins
mass_dalton
61949
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family
uniprot
proteins
pubmed
11741260
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9092568
uniprot
proteins
sequence_length
572
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q8N697}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8N697}. Endosome membrane {ECO:0000250|UniProtKB:Q8N697}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8N697}. Early endosome membrane {ECO:0000250|UniProtKB:Q91W98}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8N697}.
uniprot
proteins
transmembrane_region
TRANSMEM 27..53; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q8N697"; TRANSMEM 68..87; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q8N697"; TRANSMEM 96..116; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q8N697"; TRANSMEM 157..177; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q8N697"; TRANSMEM 195..217; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q8N697"; TRANSMEM 224..244; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q8N697"; TRANSMEM 316..337; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q8N697"; TRANSMEM 366..391; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q8N697"; TRANSMEM 404..421; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q8N697"; TRANSMEM 454..474; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q8N697"; TRANSMEM 486..509; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q8N697"; TRANSMEM 535..552; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:Q8N697
uniprot
proteins