Nap1l2
entrez
17954
canonical
uniprot
P51860
canonical
ensembl
ENSMUSG00000082229
resolver
ensp
ENSMUSP00000112677
resolver
enst
ENSMUST00000121720
resolver
genesymbol
Nap1l2
resolver
genesymbol_syn
Bpx
resolver
uniprot
Q8K3R9
resolver
uniprot_entry
NP1L2_MOUSE
resolver
uniprot_sec
Q8K3R9
resolver
amino_acid_sequence
MAESVDHKELSESNQEELGSQVMAEGPGESQDRSEGVSIEPGDGGQHGEETVAAGVGEEGKGEEAAAGSGEDAGKCGGTDEDSDSDRPKGLIGYLLDTDFVESLPVKVKCRVLALKKLQTRAAHLESKFLREFHDIERKFAEMYQPLLEKRRQIINAVYEPTEEECEYKSDCEDYFEEEMDEEEETNGNEDGMVHEYVDEDDGYEDCYYDYDDEEEEEEEDDSAGATGGEEVNEEDPKGIPDFWLTVLKNVEALTPMIKKYDEPILKLLTDIKVKLSDPGEPLSFTLEFHFKPNEYFKNELLTKTYVLKSKLACYDPHPYRGTAIEYATGCDIDWNEGKNVTLRTIKKKQRHRVWGTVRTVTEDFPKDSFFNFFSPHGISLNGGDENDDFLLGHNLRTYIIPRSVLFFSGDALESQQEGVVREVNDEIYDKIIYDDWMAAIEEVKACCKNLEALVEDIDR
uniprot
proteins
function
FUNCTION: Histone chaperone (By similarity). Plays a role in the epigenetic regulation of gene expression during cellular differentiation, by regulating the acetylation status of histone H3 and therefore chromatin accessibility (PubMed:10932189, PubMed:17591696). Plays a role in the differentiation of neuronal cells (PubMed:10932189, PubMed:17591696). Increased activity during aging may suppress osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and promote their senescence; recruits SIRT1 to deacetylate histone H3 'Lys-14' at the promoter of osteogenic genes (By similarity). {ECO:0000250|UniProtKB:P55209, ECO:0000250|UniProtKB:Q9ULW6, ECO:0000269|PubMed:10932189, ECO:0000269|PubMed:17591696}.
uniprot
proteins
mass_dalton
52158
uniprot
proteins
protein_family
Nucleosome assembly protein (NAP) family
uniprot
proteins
pubmed
10932189
uniprot
proteins
pubmed
12045143
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17591696
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
8789438
uniprot
proteins
sequence_length
460
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10932189, ECO:0000269|PubMed:17591696}. Chromosome {ECO:0000269|PubMed:17591696}. Cytoplasm, cytosol {ECO:0000269|PubMed:10932189}. Note=Localizes to chromatin in the neuronal nucleus (PubMed:17591696). Cytoplasmic in the G1 phase, nuclear during S-phase (PubMed:10932189). {ECO:0000269|PubMed:10932189, ECO:0000269|PubMed:17591696}.
uniprot
proteins