PLK3
entrez
1263
canonical
uniprot
Q9H4B4
canonical
ensembl
ENSG00000173846
resolver
ensp
ENSP00000361275
resolver
ensp
ENSP00000520901
resolver
ensp
ENSP00000687800
resolver
ensp
ENSP00000687801
resolver
enst
ENST00000372201
resolver
enst
ENST00000850614
resolver
genesymbol
PLK3
resolver
genesymbol_syn
CNK
resolver
genesymbol_syn
FNK
resolver
genesymbol_syn
PRK
resolver
hgnc
HGNC:2154
resolver
uniprot
Q15767
resolver
uniprot
Q5JR99
resolver
uniprot
Q96CV1
resolver
uniprot_entry
PLK3_HUMAN
resolver
uniprot_sec
Q15767
resolver
uniprot_sec
Q5JR99
resolver
uniprot_sec
Q96CV1
resolver
amino_acid_sequence
MEPAAGFLSPRPFQRAAAAPAPPAGPGPPPSALRGPELEMLAGLPTSDPGRLITDPRSGRTYLKGRLLGKGGFARCYEATDTETGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCSRKSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMELKVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPPFETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILRHDFFTKGYTPDRLPISSCVTVPDLTPPNPARSLFAKVTKSLFGRKKKSKNHAQERDEVSGLVSGLMRTSVGHQDARPEAPAASGPAPVSLVETAPEDSSPRGTLASSGDGFEEGLTVATVVESALCALRNCIAFMPPAEQNPAPLAQPEPLVWVSKWVDYSNKFGFGYQLSSRRVAVLFNDGTHMALSANRKTVHYNPTSTKHFSFSVGAVPRALQPQLGILRYFASYMEQHLMKGGDLPSVEEVEVPAPPLLLQWVKTDQALLMLFSDGTVQVNFYGDHTKLILSGWEPLLVTFVARNRSACTYLASHLRQLGCSPDLRQRLRYALRLLRDRSPA
uniprot
proteins
ec_number
2.7.11.21
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase involved in cell cycle regulation, response to stress and Golgi disassembly. Polo-like kinases act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates ATF2, BCL2L1, CDC25A, CDC25C, CHEK2, HIF1A, JUN, p53/TP53, p73/TP73, PTEN, TOP2A and VRK1. Involved in cell cycle regulation: required for entry into S phase and cytokinesis. Phosphorylates BCL2L1, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Plays a key role in response to stress: rapidly activated upon stress stimulation, such as ionizing radiation, reactive oxygen species (ROS), hyperosmotic stress, UV irradiation and hypoxia. Involved in DNA damage response and G1/S transition checkpoint by phosphorylating CDC25A, p53/TP53 and p73/TP73. Phosphorylates p53/TP53 in response to reactive oxygen species (ROS), thereby promoting p53/TP53-mediated apoptosis. Phosphorylates CHEK2 in response to DNA damage, promoting the G2/M transition checkpoint. Phosphorylates the transcription factor p73/TP73 in response to DNA damage, leading to inhibit p73/TP73-mediated transcriptional activation and pro-apoptotic functions. Phosphorylates HIF1A and JUN is response to hypoxia. Phosphorylates ATF2 following hyperosmotic stress in corneal epithelium. Also involved in Golgi disassembly during the cell cycle: part of a MEK1/MAP2K1-dependent pathway that induces Golgi fragmentation during mitosis by mediating phosphorylation of VRK1. May participate in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation, via its interaction with CIB1. {ECO:0000269|PubMed:10557092, ECO:0000269|PubMed:11156373, ECO:0000269|PubMed:11447225, ECO:0000269|PubMed:11551930, ECO:0000269|PubMed:11971976, ECO:0000269|PubMed:12242661, ECO:0000269|PubMed:14968113, ECO:0000269|PubMed:14980500, ECO:0000269|PubMed:15021912, ECO:0000269|PubMed:16478733, ECO:0000269|PubMed:16481012, ECO:0000269|PubMed:17264206, ECO:0000269|PubMed:17804415, ECO:0000269|PubMed:18062778, ECO:0000269|PubMed:18650425, ECO:0000269|PubMed:19103756, ECO:0000269|PubMed:19490146, ECO:0000269|PubMed:20889502, ECO:0000269|PubMed:20940307, ECO:0000269|PubMed:20951827, ECO:0000269|PubMed:21098032, ECO:0000269|PubMed:21264284, ECO:0000269|PubMed:21376736, ECO:0000269|PubMed:21840391, ECO:0000269|PubMed:9353331}.
uniprot
proteins
mass_dalton
71629
uniprot
proteins
mutagenesis
MUTAGEN 91; /note="K->R: Kinase defective mutant, abolishes activity."; /evidence="ECO:0000269|PubMed:11447225, ECO:0000269|PubMed:14980500, ECO:0000269|PubMed:17804415, ECO:0000269|PubMed:19103756, ECO:0000269|PubMed:19490146, ECO:0000269|PubMed:20889502, ECO:0000269|PubMed:20940307"; MUTAGEN 203; /note="D->A: Kinase defective mutant, abolishes activity."; /evidence="ECO:0000269|PubMed:11156373"; MUTAGEN 219; /note="T->E: Kinase-defective mutant."; /evidence="ECO:0000269|PubMed:16478733"; MUTAGEN 467..468; /note="WV->FA: Abolishes localization to the centrosome and ability to induce the G2/M arrest."; /evidence="ECO:0000269|PubMed:16478733
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in an ATM-dependent manner following DNA damage. Phosphorylated as cells enter mitosis and dephosphorylated as cells exit mitosis. {ECO:0000269|PubMed:12242661}.
uniprot
proteins
protein_family
CDC5/Polo subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Ser/Thr protein kinase family
uniprot
proteins
pubmed
10557092
uniprot
proteins
pubmed
11039900
uniprot
proteins
pubmed
11156373
uniprot
proteins
pubmed
11447225
uniprot
proteins
pubmed
11551930
uniprot
proteins
pubmed
11746980
uniprot
proteins
pubmed
11971976
uniprot
proteins
pubmed
12242661
uniprot
proteins
pubmed
14968113
uniprot
proteins
pubmed
14980500
uniprot
proteins
pubmed
15021912
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16478733
uniprot
proteins
pubmed
16481012
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17264206
uniprot
proteins
pubmed
17804415
uniprot
proteins
pubmed
18062778
uniprot
proteins
pubmed
18650425
uniprot
proteins
pubmed
19103756
uniprot
proteins
pubmed
19490146
uniprot
proteins
pubmed
20473878
uniprot
proteins
pubmed
20671765
uniprot
proteins
pubmed
20889502
uniprot
proteins
pubmed
20940307
uniprot
proteins
pubmed
20951827
uniprot
proteins
pubmed
21098032
uniprot
proteins
pubmed
21264284
uniprot
proteins
pubmed
21376736
uniprot
proteins
pubmed
21840391
uniprot
proteins
pubmed
8702627
uniprot
proteins
pubmed
9353331
uniprot
proteins
sequence_length
646
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus, nucleolus. Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Translocates to the nucleus upon cisplatin treatment. Localizes to the Golgi apparatus during interphase. According to a report, PLK3 localizes only in the nucleolus and not in the centrosome, or in any other location in the cytoplasm (PubMed:17264206). The discrepancies in results may be explained by the PLK3 antibody specificity, by cell line-specific expression or post-translational modifications. {ECO:0000269|PubMed:17264206}.
uniprot
proteins