OR5AN1
entrez
390195
canonical
uniprot
Q8NGI8
canonical
ensembl
ENSG00000176495
resolver
ensp
ENSP00000320302
resolver
ensp
ENSP00000492957
resolver
ensp
ENSP00000493250
resolver
enst
ENST00000313940
resolver
enst
ENST00000641850
resolver
enst
ENST00000641998
resolver
genesymbol
OR5AN1
resolver
hgnc
HGNC:15255
resolver
uniprot
B9EIS2
resolver
uniprot
Q6IEV4
resolver
uniprot_entry
O5AN1_HUMAN
resolver
uniprot_sec
B9EIS2
resolver
uniprot_sec
Q6IEV4
resolver
amino_acid_sequence
MTGGGNITEITYFILLGFSDFPRIIKVLFTIFLVIYITSLAWNLSLIVLIRMDSHLHTPMYFFLSNLSFIDVCYISSTVPKMLSNLLQEQQTITFVGCIIQYFIFSTMGLSESCLMTAMAYDRYAAICNPLLYSSIMSPTLCVWMVLGAYMTGLTASLFQIGALLQLHFCGSNVIRHFFCDMPQLLILSCTDTFFVQVMTAILTMFFGIASALVIMISYGYIGISIMKITSAKGRSKAFNTCASHLTAVSLFYTSGIFVYLSSSSGGSSSFDRFASVFYTVVIPMLNPLIYSLRNKEIKDALKRLQKRKCC
uniprot
proteins
function
FUNCTION: Odorant receptor for musk, which specifically recognizes muscone, musk xylol, and musk ketone (PubMed:24361078, PubMed:25901328, PubMed:27098692, PubMed:29632183, PubMed:36625229). Has chiral selectivity for (R)- over (S)-muscone (PubMed:29632183). Ligand-binding causes a conformation change that triggers signaling via G(s)-class of G alpha protein GNAL, activating adenylyl cyclase (Probable). {ECO:0000269|PubMed:24361078, ECO:0000269|PubMed:25901328, ECO:0000269|PubMed:27098692, ECO:0000269|PubMed:29632183, ECO:0000269|PubMed:36625229, ECO:0000305}.
uniprot
proteins
mass_dalton
34789
uniprot
proteins
mutagenesis
MUTAGEN 260; /note="Y->F: Abolished activation by musk."; /evidence="ECO:0000269|PubMed:29632183"; MUTAGEN 279; /note="Y->A: Decreased activation by musk."; /evidence="ECO:0000269|PubMed:29632183
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
14983052
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24361078
uniprot
proteins
pubmed
25901328
uniprot
proteins
pubmed
27098692
uniprot
proteins
pubmed
29632183
uniprot
proteins
pubmed
36625229
uniprot
proteins
sequence_length
311
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:24361078, ECO:0000305|PubMed:25901328}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 27..47; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 56..76; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 101..121; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 135..155; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 198..218; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 239..259; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 273..293; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins