P36268
uniprot
P36268
canonical
amino_acid_sequence
MKKKLVVLGLLAVVLVLVIVGLCLWLPSASKEPDNHVYTRAAMAADAKQCLEIGRDTLRDGGSAVDAAIAALLCVGLMNAHSMGIGVGLFLTIYNSTTGKAEVINAREVAPRLAFASMFNSSEQSQKGGLSVAVPGEIRGYELAHQRHGRLPWARLFQPSIQLARQGFPVGKGLAAVLENKRTVIEQQPVLWYVFCRDRKVLREGERLTLPRLADTYEMLAIEGAQAFYNGSLMAQIVKDIQAAGGIVTAEDLNNYRAELIEHPLNISLGDAVLYMPSARLSGPVLALILNILKGYNFSRESVETPEQKGLTYHRIVEAFRFAYAKRTLLGDPKFVDVTEVVRNMTSEFFAAQLRSQISDHTTHPISYYKPEFYTPDDGGTAHLSVVAEDGSAVSATSTINLYFGSKVCSPVSGILFNNEWTTSALPAFTNEFGAPPSPANFIQPGKQPLLSMCLTIMVGQDGQVRMVVGAAGGTQITTDTALAIIYNLWFGYDVKRAVEEPRLHNKLLPNVTTVERNIDQAVTAALETRHHHTQIASTFIAVVQAIVRTAGGWAAALDSRKGGEPAGY
uniprot
proteins
function
FUNCTION: [Isoform 1]: Lacks catalytic activity due to its inability to undergo the autocatalytic cleavage needed to produce a mature, enzymatically active heterodimer. {ECO:0000269|PubMed:23682772}.; FUNCTION: [Isoform 2]: Lacks catalytic activity due to its inability to undergo the autocatalytic cleavage needed to produce a mature, enzymatically active heterodimer. {ECO:0000269|PubMed:23682772}.; FUNCTION: [Isoform 3]: Lacks catalytic activity due to its inability to undergo the autocatalytic cleavage needed to produce a mature, enzymatically active heterodimer. {ECO:0000269|PubMed:23682772}.
uniprot
proteins
mass_dalton
61771
uniprot
proteins
mutagenesis
MUTAGEN 192; /note="W->C: No effect on the absence of autocatalytic cleavage and catalytic activity; when associated with E-193."; /evidence="ECO:0000269|PubMed:23682772"; MUTAGEN 193; /note="Y->E: No effect on the absence of autocatalytic cleavage and catalytic activity; when associated with C-192."; /evidence="ECO:0000269|PubMed:23682772
uniprot
proteins
post_translational_modification
PTM: Not cleaved by autocatalysis into a large and a small subunit resulting in loss of cell membrane localization and catalytic activity. {ECO:0000269|PubMed:23682772}.
uniprot
proteins
protein_family
Gamma-glutamyltransferase family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
23682772
uniprot
proteins
pubmed
2573352
uniprot
proteins
sequence_length
569
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:23682772}. Endoplasmic reticulum {ECO:0000269|PubMed:23682772}. Note=Co-localizes with calnexin in the endoplasmic reticulum.
uniprot
proteins