EPB41
entrez
2035
canonical
uniprot
P11171
canonical
ensembl
ENSG00000159023
resolver
ensp
ENSP00000290100
resolver
ensp
ENSP00000317597
resolver
ensp
ENSP00000345259
resolver
ensp
ENSP00000362903
resolver
ensp
ENSP00000362904
resolver
ensp
ENSP00000362906
resolver
ensp
ENSP00000493575
resolver
ensp
ENSP00000494212
resolver
ensp
ENSP00000494435
resolver
ensp
ENSP00000494945
resolver
ensp
ENSP00000495138
resolver
ensp
ENSP00000496138
resolver
ensp
ENSP00000496326
resolver
ensp
ENSP00000516349
resolver
ensp
ENSP00000540309
resolver
ensp
ENSP00000540310
resolver
ensp
ENSP00000540311
resolver
ensp
ENSP00000540312
resolver
ensp
ENSP00000540313
resolver
ensp
ENSP00000540314
resolver
ensp
ENSP00000540315
resolver
ensp
ENSP00000591752
resolver
ensp
ENSP00000591757
resolver
ensp
ENSP00000591758
resolver
ensp
ENSP00000591760
resolver
ensp
ENSP00000591761
resolver
ensp
ENSP00000591762
resolver
ensp
ENSP00000591763
resolver
ensp
ENSP00000591764
resolver
ensp
ENSP00000591765
resolver
ensp
ENSP00000591767
resolver
ensp
ENSP00000591772
resolver
ensp
ENSP00000591780
resolver
ensp
ENSP00000591782
resolver
ensp
ENSP00000591783
resolver
ensp
ENSP00000591785
resolver
ensp
ENSP00000591786
resolver
ensp
ENSP00000591789
resolver
ensp
ENSP00000659080
resolver
ensp
ENSP00000748896
resolver
ensp
ENSP00000748897
resolver
ensp
ENSP00000748898
resolver
ensp
ENSP00000748899
resolver
ensp
ENSP00000748900
resolver
enst
ENST00000349460
resolver
enst
ENST00000642937
resolver
enst
ENST00000643604
resolver
enst
ENST00000644342
resolver
enst
ENST00000644600
resolver
enst
ENST00000647103
resolver
enst
ENST00000706361
resolver
genesymbol
EPB41
resolver
genesymbol_syn
E41P
resolver
hgnc
HGNC:3377
resolver
uniprot
A0A2R8Y5G2
resolver
uniprot
A0A2R8Y5Z6
resolver
uniprot
A0A2R8Y6D0
resolver
uniprot
A0A2R8Y7Y3
resolver
uniprot
A0A2R8YD30
resolver
uniprot
A0A2U3TZH6
resolver
uniprot
A0A994J847
resolver
uniprot
B1ALH8
resolver
uniprot
B1ALH9
resolver
uniprot
D3DPM9
resolver
uniprot
D3DPN0
resolver
uniprot
P11176
resolver
uniprot
Q14245
resolver
uniprot
Q1WWM3
resolver
uniprot
Q29RX4
resolver
uniprot
Q59F12
resolver
uniprot
Q5TB35
resolver
uniprot
Q5VXN8
resolver
uniprot
Q8IXV9
resolver
uniprot
Q9Y578
resolver
uniprot
Q9Y579
resolver
uniprot_entry
A0A2R8Y5G2_HUMAN
resolver
uniprot_entry
A0A2R8Y5Z6_HUMAN
resolver
uniprot_entry
A0A2R8Y6D0_HUMAN
resolver
uniprot_entry
A0A2R8Y7Y3_HUMAN
resolver
uniprot_entry
A0A2R8YD30_HUMAN
resolver
uniprot_entry
A0A2U3TZH6_HUMAN
resolver
uniprot_entry
A0A994J847_HUMAN
resolver
uniprot_entry
EPB41_HUMAN
resolver
uniprot_entry
Q1WWM3_HUMAN
resolver
uniprot_entry
Q29RX4_HUMAN
resolver
uniprot_entry
Q59F12_HUMAN
resolver
uniprot_sec
B1ALH8
resolver
uniprot_sec
B1ALH9
resolver
uniprot_sec
D3DPM9
resolver
uniprot_sec
D3DPN0
resolver
uniprot_sec
P11176
resolver
uniprot_sec
Q14245
resolver
uniprot_sec
Q5TB35
resolver
uniprot_sec
Q5VXN8
resolver
uniprot_sec
Q8IXV9
resolver
uniprot_sec
Q9Y578
resolver
uniprot_sec
Q9Y579
resolver
amino_acid_sequence
MTTEKSLVTEAENSQHQQKEEGEEAINSGQQEPQQEESCQTAAEGDNWCEQKLKASNGDTPTHEDLTKNKERTSESRGLSRLFSSFLKRPKSQVSEEEGKEVESDKEKGEGGQKEIEFGTSLDEEIILKAPIAAPEPELKTDPSLDLHSLSSAETQPAQEELREDPDFEIKEGEGLEECSKIEVKEESPQSKAETELKASQKPIRKHRNMHCKVSLLDDTVYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAIWDNATSKTWLDSAKEIKKQVRGVPWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSELGDYDPELHGVDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQADLEFLENAKKLSMYGVDLHKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFFIKIRPGEQEQYESTIGFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTIPKSKFLALGSKFRYSGRTQAQTRQASALIDRPAPHFERTASKRASRSLDGAAAVDSADRSPRPTSAPAITQGQVAEGGVLDASAKKTVVPKAQKETVKAEVKKEDEPPEQAEPEPTEAWKVEKTHIEVTVPTSNGDQTQKLAEKTEDLIRMRKKKRERLDGENIYIRHSNLMLEDLDKSQEEIKKHHASISELKKNFMESVPEPRPSEWDKRLSTHSPFRTLNINGQIPTGEGPPLVKTQTVTISDNANAVKSEIPTKDVPIVHTETKTITYEAAQTDDNSGDLDPGVLLTAQTITSETPSSTTTTQITKTVKGGISETRIEKRIVITGDADIDHDQVLVQAIKEAKEQHPDMSVTKVVVHQETEIADE
uniprot
proteins
disease_involvement
DISEASE: Elliptocytosis 1 (EL1) [MIM:611804]: A Rhesus-linked form of hereditary elliptocytosis, a genetically heterogeneous, autosomal dominant hematologic disorder. It is characterized by variable hemolytic anemia and elliptical or oval red cell shape. {ECO:0000269|PubMed:3467321}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). {ECO:0000269|PubMed:23870127}.
uniprot
proteins
mass_dalton
97017
uniprot
proteins
mutagenesis
MUTAGEN 60; /note="T->A: Loss of CDK1-mediated phosphorylation. Abolishes targeting onto the mitotic spindle; when associated with A-712."; /evidence="ECO:0000269|PubMed:15525677"; MUTAGEN 712; /note="S->A: Loss of CDK1-mediated phosphorylation. Abolishes targeting onto the mitotic spindle; when associated with A-60."; /evidence="ECO:0000269|PubMed:15525677
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at multiple sites by different protein kinases and each phosphorylation event selectively modulates the protein's functions.; PTM: Phosphorylation on Tyr-660 reduces the ability of 4.1 to promote the assembly of the spectrin/actin/4.1 ternary complex. {ECO:0000269|PubMed:1647028}.; PTM: O-glycosylated; contains N-acetylglucosamine side chains in the C-terminal domain.
uniprot
proteins
pubmed
10692436
uniprot
proteins
pubmed
11003675
uniprot
proteins
pubmed
11017195
uniprot
proteins
pubmed
11432737
uniprot
proteins
pubmed
12427749
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15525677
uniprot
proteins
pubmed
1647028
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
2022644
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
2171679
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23870127
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
2808371
uniprot
proteins
pubmed
3194408
uniprot
proteins
pubmed
3223413
uniprot
proteins
pubmed
3375238
uniprot
proteins
pubmed
3467321
uniprot
proteins
pubmed
3531202
uniprot
proteins
pubmed
7937897
uniprot
proteins
sequence_length
864
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12427749}. Cytoplasm, cell cortex {ECO:0000269|PubMed:12427749, ECO:0000269|PubMed:23870127}. Nucleus {ECO:0000269|PubMed:12427749}.
uniprot
proteins