Trpv2
entrez
22368
canonical
uniprot
Q9WTR1
canonical
ensembl
ENSMUSG00000018507
resolver
ensp
ENSMUSP00000018651
resolver
ensp
ENSMUSP00000099703
resolver
ensp
ENSMUSP00000199023
resolver
enst
ENSMUST00000018651
resolver
enst
ENSMUST00000102643
resolver
genesymbol
Trpv2
resolver
genesymbol_syn
Grc
resolver
uniprot
Q99K71
resolver
uniprot_entry
TRPV2_MOUSE
resolver
uniprot_sec
Q99K71
resolver
activity_regulation
ACTIVITY REGULATION: Activated by temperatures higher than 52 degrees Celsius (By similarity). Weakly activated by cannabinoid that binds to the vanilloid binding pocket; this activation is potentiated by the binding of uricosuric agents like probenecid (By similarity). {ECO:0000250|UniProtKB:Q9WUD2}.
uniprot
proteins
amino_acid_sequence
MTSASNPPAFRLETSDGDEEGSAEVNKGKNEPPPMESPFQGEDRNFSPQIKVNLNYRKGLGPSQQDPNRFDRDRLFSVVSRGVPEELTGLLEYLRRTSKYLTDSAYTEGSTGKTCLMKAVLNLQDGVNACILPLLQIDRDSGNPQPLVNAQCTDEFYRGHSALHIAIEKRSLWCVKLLVENGANVHIRACGRFFQKHQGTCFYFGELPLSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDSLLQMGARLCPTVQLEDICNHQGLTPLKLAAKEGKIEIFRHILQREFSGLYQPLSRKFTEWCYGPVRVSLYDLSSVDSWEKNSVLEIIAFHCKSPHRHRMVVLEPLNKLLQEKWDRLIPRFFFNFACYLVYMIIFTIVAYHQPSLEQPAIPSSKATFGDSMLLLGHILILLGGIYLLLGQLWYFWRRRLFIWISFMDSYFEILFLVQALLTVLSQVLRFVETEWYLPLLVSSLVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLVYLVFLFGFAVALVSLSREARSPKAPEDSNTTVTEKPTLGQEEEPVPYGGILDASLELFKFTIGMGELAFQEQLRFRGVVLLLLLAYVLLTYVLLLNMLIALMSETVNSVATDSWSIWKLQKAISVLEMENGYWWCRRKRHRAGRLLKVGTKGDGIPDERWCFRVEEVNWAAWEKTLPTLSEDPSGAGITGYKKNPTSKPGKNSASEEDHLPLQVLQSH
uniprot
proteins
function
FUNCTION: Calcium-permeable, non-selective cation channel (PubMed:10559903). Seems to be regulated, at least in part, by growth factors, such as IGF1, PDGF and morphogenetic neuropeptide/head activator (PubMed:10559903, PubMed:11707512). May transduce physical stimuli in mast cells (By similarity). {ECO:0000250|UniProtKB:Q9WUD2, ECO:0000269|PubMed:10559903, ECO:0000269|PubMed:11707512}.
uniprot
proteins
mass_dalton
85965
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:10559903}.; PTM: Phosphorylated by PKA. {ECO:0000250|UniProtKB:Q9WUD2}.
uniprot
proteins
protein_family
TRPV2 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
protein_family
TrpV subfamily
uniprot
proteins
pubmed
10559903
uniprot
proteins
pubmed
11707512
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
756
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10559903}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9WUD2}. Cytoplasm {ECO:0000269|PubMed:10559903}. Melanosome {ECO:0000250|UniProtKB:Q9Y5S1}. Note=Translocates from the cytoplasm to the plasma membrane upon ligand stimulation. {ECO:0000269|PubMed:10559903}.
uniprot
proteins
transmembrane_region
TRANSMEM 388..406; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q9WUD2"; TRANSMEM 427..449; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q9WUD2"; TRANSMEM 466..484; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q9WUD2"; TRANSMEM 491..511; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q9WUD2"; TRANSMEM 532..553; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q9WUD2"; TRANSMEM 616..636; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q9WUD2
uniprot
proteins