Slc9a3
entrez
105243
canonical
uniprot
G3X939
canonical
ensembl
ENSMUSG00000036123
resolver
ensp
ENSMUSP00000038142
resolver
ensp
ENSMUSP00000152682
resolver
enst
ENSMUST00000036208
resolver
enst
ENSMUST00000221703
resolver
genesymbol
Slc9a3
resolver
uniprot
Q8BZU0
resolver
uniprot_entry
SL9A3_MOUSE
resolver
uniprot_sec
Q8BZU0
resolver
activity_regulation
ACTIVITY REGULATION: Seems to switch between active and inactive modes in response to various stimuli (By similarity). Activated directly or indirectly by membrane phosphatidylinositol (PIs) (By similarity). Regulated by a variety of auxiliary proteins, which facilitate the maturation, cell surface expression and function of the transporter. Inhibited specifically by the drug tenapanor (By similarity). {ECO:0000250|UniProtKB:P26432, ECO:0000250|UniProtKB:P48764}.
uniprot
proteins
amino_acid_sequence
MWHRALGPGWKLLLALALTSLQGARGAEEEPSSDGSFQVVTFKWHHVQDPYIIALWILVASLAKIVFHLSHKVTSIVPESALLIVLGLVLGGIVWAADHIASFTLTPTLFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVIGTIWNAATTGLSLYGVFLSGLMGELKIGLLDFLLFGSLIAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFESFVTLGGDAVTGVDCVKGIVSFFVVSLGGTLVGVIFAFLLSLVTRFTKHVRIIEPGFVFVISYLSYLTSEMLSLSSILAITFCGICCQKYVKANISEQSATTVRYTMKMLASGAETIIFMFLGISAVNPDIWTWNTAFVLLTLVFISVYRAIGVVLQTWILNRYRMVQLETIDQVVMSYGGLRGAVAYALVVLLDEKKVKEKNLFVSTTLIVVFFTVIFQGLTIKPLVQWLKVKRSEHREPKLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWSNFDRKFLSKVLMRRSAQKSRDRILNVFHELNLKDAISYVAEGERRGSLAFIRSPSTDNMVNVDFNTPRPSTVEASVSYFLRENVSAVCLDMQSLEQRRRSIRDTEDMVTHHTLQQYLYKPRQEYKHLYSRHELTPNEDEKQDKEIFHRTMRKRLESFKSAKLGINQNKKAAKLYKRERAQKRRNSSIPNGKLPMENLAHNYTIKEKDLELSEHEEATNYEEISGGIEFLASVTQDVASDSGAGIDNPVFSPDEDLDPSILSRVPPWLSPGETVVPSQRARVQIPNSPSNFRRLTPFRLSNKSVDSFLQADGHEEQLQPAAPESTHM
uniprot
proteins
function
FUNCTION: Plasma membrane Na(+)/H(+) antiporter. Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, playing a key role in salt and fluid absorption and pH homeostasis (By similarity). Major apical Na(+)/H(+) exchanger in kidney and intestine playing an important role in renal and intestine Na(+) absorption and blood pressure regulation (PubMed:9662405). {ECO:0000250|UniProtKB:P48764, ECO:0000269|PubMed:9662405}.
uniprot
proteins
mass_dalton
93104
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKA, which inhibits activity. Phosphorylation at Ser-659 by SGK1 is associated with increased abundance at the cell membrane. Phosphorylation at Ser-714 by CSNK2A1 regulates SLC9A3 activity through the formation of multiple signaling complexes (By similarity). {ECO:0000250|UniProtKB:P26432, ECO:0000250|UniProtKB:P26433}.
uniprot
proteins
protein_family
Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9662405
uniprot
proteins
sequence_length
829
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:P48764}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48764}. Cell membrane {ECO:0000250|UniProtKB:P48764}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48764}. Recycling endosome membrane {ECO:0000250|UniProtKB:P48764}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48764}. Early endosome membrane {ECO:0000250|UniProtKB:P48764}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48764}. Note=In intestinal epithelial cells, localizes to the ileal brush border. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane. Angiotensin-2 enhances apical expression (By similarity). {ECO:0000250|UniProtKB:Q28362}.
uniprot
proteins
transmembrane_region
TRANSMEM 47..69; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P48764"; TRANSMEM 78..97; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P48764"; TRANSMEM 107..124; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P48764"; TRANSMEM 128..163; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P48764"; TRANSMEM 177..198; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P48764"; TRANSMEM 201..232; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P48764"; TRANSMEM 240..274; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P48764"; TRANSMEM 277..299; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P48764"; TRANSMEM 302..318; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:P48764"; TRANSMEM 326..354; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:P48764"; TRANSMEM 363..384; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:P48764"; TRANSMEM 398..421; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:P48764"; TRANSMEM 429..462; /note="Helical; Name=13"; /evidence="ECO:0000250|UniProtKB:P48764
uniprot
proteins