CAPN2
entrez
824
canonical
uniprot
P17655
canonical
ensembl
ENSG00000162909
resolver
ensp
ENSP00000295006
resolver
ensp
ENSP00000413158
resolver
ensp
ENSP00000726119
resolver
genesymbol
CAPN2
resolver
genesymbol_syn
CANPL2
resolver
hgnc
HGNC:1479
resolver
uniprot
A6NDG7
resolver
uniprot
B4DN77
resolver
uniprot
B7ZA96
resolver
uniprot
E7ES58
resolver
uniprot
Q16738
resolver
uniprot
Q59EF6
resolver
uniprot
Q6PJT3
resolver
uniprot
Q8WU26
resolver
uniprot
Q9HBB1
resolver
uniprot_entry
B4DN77_HUMAN
resolver
uniprot_entry
CAN2_HUMAN
resolver
uniprot_entry
Q59EF6_HUMAN
resolver
uniprot_sec
A6NDG7
resolver
uniprot_sec
B7ZA96
resolver
uniprot_sec
E7ES58
resolver
uniprot_sec
Q16738
resolver
uniprot_sec
Q6PJT3
resolver
uniprot_sec
Q8WU26
resolver
uniprot_sec
Q9HBB1
resolver
activity_regulation
ACTIVITY REGULATION: Activated by 200-1000 micromolar concentrations of calcium and inhibited by calpastatin.
uniprot
proteins
amino_acid_sequence
MAGIAAKLAKDREAAEGLGSHDRAIKYLNQDYEALRNECLEAGTLFQDPSFPAIPSALGFKELGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELKKPPPNLFKIIQKALQKGSLLGCSIDITSAADSEAITFQKLVKGHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRHEDGEFWMSFSDFLRHYSRLEICNLTPDTLTSDTYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGESGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELSGQTNIHLSKNFFLTNRARERSDTFINLREVLNRFKLPPGEYILVPSTFEPNKDGDFCIRVFSEKKADYQAVDDEIEANLEEFDISEDDIDDGFRRLFAQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDSDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKMPCQLHQVIVARFADDQLIIDFDNFVRCLVRLETLFKIFKQLDPENTGTIELDLISWLCFSVL
uniprot
proteins
ec_number
3.4.22.53
uniprot
proteins
function
FUNCTION: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (By similarity). {ECO:0000250|UniProtKB:O08529, ECO:0000269|PubMed:17650508}.
uniprot
proteins
mass_dalton
79995
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated via 'Lys6'-linked chains by the E3 ubiquitin ligase complex at least composed of CUL3, KCTD7 and RBX1 to execute atypical, non-degradative ubiquitination. {ECO:0000269|PubMed:36964131}.
uniprot
proteins
protein_family
Peptidase C2 family
uniprot
proteins
pubmed
10639123
uniprot
proteins
pubmed
10944468
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17650508
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2539381
uniprot
proteins
pubmed
2852952
uniprot
proteins
pubmed
36964131
uniprot
proteins
pubmed
39532532
uniprot
proteins
sequence_length
700
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:36964131}. Cell membrane. Note=Translocates to the plasma membrane upon Ca(2+) binding.
uniprot
proteins