NAPRT
entrez
93100
canonical
uniprot
Q6XQN6
canonical
ensembl
ENSG00000147813
resolver
ensembl
ENSG00000278488
resolver
ensp
ENSP00000390949
resolver
ensp
ENSP00000401508
resolver
ensp
ENSP00000566768
resolver
genesymbol
NAPRT
resolver
genesymbol_syn
FHIP
resolver
genesymbol_syn
NAPRT1
resolver
hgnc
HGNC:30450
resolver
uniprot
A7BFI3
resolver
uniprot
Q6PJL1
resolver
uniprot
Q6XQN4
resolver
uniprot
Q6XQN5
resolver
uniprot
Q8N5E8
resolver
uniprot
Q9BRG0
resolver
uniprot_entry
PNCB_HUMAN
resolver
uniprot_sec
A7BFI3
resolver
uniprot_sec
Q6PJL1
resolver
uniprot_sec
Q6XQN4
resolver
uniprot_sec
Q6XQN5
resolver
uniprot_sec
Q8N5E8
resolver
uniprot_sec
Q9BRG0
resolver
amino_acid_sequence
MAAEQDPEARAAARPLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPDTDPAFFEHLRALDCSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPEKRLLEMGLRRAQGPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFSGSEVPPDPMLAPAAGEGPGVDLAAKAQVWLEQVCAHLGLGVQEPHPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAQEIRKVFRAAAAQFQVPWLESVLIVVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGGVYKLVAVGGQPRMKLTEDPEKQTLPGSKAAFRLLGSDGSPLMDMLQLAEEPVPQAGQELRVWPPGAQEPCTVRPAQVEPLLRLCLQQGQLCEPLPSLAESRALAQLSLSRLSPEHRRLRSPAQYQVVLSERLQALVNSLCAGQSP
uniprot
proteins
ec_number
6.3.4.21
uniprot
proteins
function
FUNCTION: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate (PubMed:17604275, PubMed:21742010, PubMed:26042198). Helps prevent cellular oxidative stress via its role in NAD biosynthesis (PubMed:17604275). {ECO:0000269|PubMed:17604275, ECO:0000269|PubMed:21742010, ECO:0000269|PubMed:26042198}.
uniprot
proteins
mass_dalton
57578
uniprot
proteins
mutagenesis
MUTAGEN 19; /note="D->A: Complete loss of activity."; /evidence="ECO:0000269|PubMed:21742010"; MUTAGEN 21; /note="Y->A: Partial loss of activity in the presence of ATP, complete loss in the absence of ATP."; /evidence="ECO:0000269|PubMed:21742010"; MUTAGEN 169; /note="G->A: Partial loss of activity."; /evidence="ECO:0000269|PubMed:21742010"; MUTAGEN 209; /note="G->A: Partial loss of activity."; /evidence="ECO:0000269|PubMed:21742010"; MUTAGEN 213; /note="H->A: Partial loss of activity."; /evidence="ECO:0000269|PubMed:21742010"; MUTAGEN 288; /note="D->A: Partial loss of activity."; /evidence="ECO:0000269|PubMed:21742010"; MUTAGEN 318; /note="R->A: Partial loss of activity in the presence of ATP, almost complete loss in the absence of ATP."; /evidence="ECO:0000269|PubMed:21742010"; MUTAGEN 357; /note="N->A: Small loss of activity."; /evidence="ECO:0000269|PubMed:21742010"; MUTAGEN 379; /note="G->A: Complete loss of activity."; /evidence="ECO:0000269|PubMed:21742010"; MUTAGEN 380; /note="T->A: Partial loss of activity."; /evidence="ECO:0000269|PubMed:21742010"; MUTAGEN 381; /note="S->A: Partial loss of activity."; /evidence="ECO:0000269|PubMed:21742010
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. {ECO:0000269|PubMed:17604275, ECO:0000269|PubMed:21742010, ECO:0000269|PubMed:26042198}.
uniprot
proteins
post_translational_modification
PTM: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. {ECO:0000250|UniProtKB:P22253}.
uniprot
proteins
protein_family
NAPRTase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17604275
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21742010
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26042198
uniprot
proteins
sequence_length
538
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:17604275}.
uniprot
proteins