Slc15a3
entrez
65221
canonical
uniprot
Q8BPX9
canonical
ensembl
ENSMUSG00000024737
resolver
ensp
ENSMUSP00000025646
resolver
enst
ENSMUST00000025646
resolver
genesymbol
Slc15a3
resolver
genesymbol_syn
Ci1
resolver
genesymbol_syn
Pht2
resolver
uniprot
Q9WU80
resolver
uniprot_entry
S15A3_MOUSE
resolver
uniprot_sec
Q9WU80
resolver
amino_acid_sequence
MSAPRAEEQPSRSGERQPLVARGPRGPRRWRRTAAAAVLLVQMLERAAFFGVTSNLVLYLNSLNFNWDGQQASRATLLFLGASYLLAPVGGWLADVYLGRFLTISLSLLLYLAASGLLLTTITNDGRRSFCGEMPELPLEPACPSSSCQGSWSSPYCATTLYLVLLLLALAASSVRSTLTSFGADQVMDLGRDATRRFFNWFYWSINLGAILSLLVVAFIEQNISFLWGYSIIVGLVGLAFFIFLFATPVFITKPPTGSQVSSMLKLAFQNCCPCRRSSSRDSESAHLLPDQRSNQPGPSPQEDMANFQVLVKILPVMVTLVPYWMVYFQMQSTYVLQGLHLHIPNIFRTNPNISLLLRSDSSNYRIPEAWLLLANVAVILILIPVKDHLIDPLLLRCKLLPSSLQKMALGMFFGFTSIIVAGVLEKERLQYIAANQTVPQLIGKDLYYAAPLSIWWQIPQYLLIGVSEIFASIPGLEFAYSEAPRSMQGAIMGIFFCLSGVGSLLGSGLVALLSFPGGWMYCPKDFGNINNCQMDRYFFLLAGIEAVTAVLFLWIAGRYERTRQDPASQRSSSRVRG
uniprot
proteins
function
FUNCTION: Proton-coupled amino-acid transporter that transports free histidine and certain di- and tripeptides, and is involved in innate immune response (PubMed:24695226, PubMed:39719710). Preferably binds to short peptides with a basic residue at the first position and a hydrophobic residue at the second position (PubMed:39719710). Also able to transport carnosine (By similarity). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (PubMed:24695226). {ECO:0000250|UniProtKB:Q8IY34, ECO:0000269|PubMed:24695226, ECO:0000269|PubMed:39719710}.
uniprot
proteins
mass_dalton
64051
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family
uniprot
proteins
pubmed
11004510
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
24695226
uniprot
proteins
pubmed
39719710
uniprot
proteins
sequence_length
578
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:24695226}; Multi-pass membrane protein {ECO:0000269|PubMed:39719710}. Endosome membrane {ECO:0000269|PubMed:24695226}; Multi-pass membrane protein {ECO:0000269|PubMed:39719710}.
uniprot
proteins
transmembrane_region
TRANSMEM 33..56; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX1"; TRANSMEM 75..90; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX1"; TRANSMEM 103..122; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX1"; TRANSMEM 161..175; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX1"; TRANSMEM 201..221; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX1"; TRANSMEM 226..248; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX1"; TRANSMEM 314..333; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX1"; TRANSMEM 370..384; /note="Helical; Name=8"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX1"; TRANSMEM 408..424; /note="Helical; Name=9"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX1"; TRANSMEM 462..471; /note="Helical; Name=10"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX1"; TRANSMEM 495..514; /note="Helical; Name=11"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX1"; TRANSMEM 538..558; /note="Helical; Name=12"; /evidence="ECO:0000269|PubMed:39719710, ECO:0007744|PDB:8WX1
uniprot
proteins