CDADC1
entrez
81602
canonical
uniprot
Q9BWV3
canonical
ensembl
ENSG00000102543
resolver
ensp
ENSP00000251108
resolver
ensp
ENSP00000795635
resolver
genesymbol
CDADC1
resolver
hgnc
HGNC:20299
resolver
uniprot
Q49A08
resolver
uniprot
Q4G119
resolver
uniprot
Q5TAW9
resolver
uniprot
Q7Z764
resolver
uniprot
Q9NT36
resolver
uniprot_entry
CDAC1_HUMAN
resolver
uniprot_sec
Q49A08
resolver
uniprot_sec
Q4G119
resolver
uniprot_sec
Q5TAW9
resolver
uniprot_sec
Q7Z764
resolver
uniprot_sec
Q9NT36
resolver
amino_acid_sequence
MKEAGQMQNLESARAGRSVSTQTGSMTGQIPRLSKVNLFTLLSLWMELFPAEAQRQKSQKNEEGKHGPLGDNEERTRVSTDKRQVKRTGLVVVKNMKIVGLHCSSEDLHAGQIALIKHGSRLKNCDLYFSRKPCSACLKMIVNAGVNRISYWPADPEISLLTEASSSEDAKLDAKAVERLKSNSRAHVCVLLQPLVCYMVQFVEETSYKCDFIQKITKTLPDANTDFYYECKQERIKEYEMLFLVSNEEMHKQILMTIGLENLCENPYFSNLRQNMKDLILLLATVASSVPNFKHFGFYRSNPEQINEIHNQSLPQEIARHCMVQARLLAYRTEDHKTGVGAVIWAEGKSRSCDGTGAMYFVGCGYNAFPVGSEYADFPHMDDKQKDREIRKFRYIIHAEQNALTFRCQEIKPEERSMIFVTKCPCDECVPLIKGAGIKQIYAGDVDVGKKKADISYMRFGELEGVSKFTWQLNPSGAYGLEQNEPERRENGVLRPVPQKEEQHQDKKLRLGIH
uniprot
proteins
ec_number
3.5.4.13
uniprot
proteins
function
FUNCTION: Catalyzes the deamination of dCTP to dUTP, exhibiting a strong substrate preference for dCTP over CTP (PubMed:40324085, PubMed:40504152). No deaminase activity toward 5-methyl-dCTP, cytidine, or deoxycytidine (PubMed:40324085, PubMed:40504152). May play an important role in testicular development and spermatogenesis (PubMed:16955368). In addition to its role on endogenous nucleotides, it deaminates the active triphosphate forms of the cytidine analog drugs, gemcitabine (dFdCTP) and decitabine (5-aza-dCTP), rendering them susceptible to inactivation by deoxyuridine triphosphatase (DUT). This process limits drug-induced cytotoxicity and contributes to cellular resistance to gemcitabine and decitabine (PubMed:40504152). {ECO:0000269|PubMed:16955368, ECO:0000269|PubMed:40324085, ECO:0000269|PubMed:40504152}.
uniprot
proteins
mass_dalton
58455
uniprot
proteins
mutagenesis
MUTAGEN 400; /note="E->A: Abolished dCTP deaminase activity."; /evidence="ECO:0000269|PubMed:40324085, ECO:0000269|PubMed:40504152
uniprot
proteins
protein_family
Cytidine and deoxycytidylate deaminase family
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16955368
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
26945630
uniprot
proteins
pubmed
40324085
uniprot
proteins
pubmed
40504152
uniprot
proteins
sequence_length
514
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:26945630}. Nucleus {ECO:0000305|PubMed:26945630}. Note=Can shuttle between cytoplasm and nucleus in a cell cycle-dependent manner. {ECO:0000305|PubMed:26945630}.
uniprot
proteins