Brd2
entrez
294276
canonical
uniprot
Q6MGA9
canonical
ensembl
ENSRNOG00000000461
resolver
ensembl
ENSRNOG00055007432
resolver
ensembl
ENSRNOG00060006867
resolver
ensembl
ENSRNOG00065029616
resolver
ensp
ENSRNOP00000072049
resolver
ensp
ENSRNOP00000082798
resolver
ensp
ENSRNOP00000098184
resolver
ensp
ENSRNOP00055009865
resolver
ensp
ENSRNOP00060008434
resolver
ensp
ENSRNOP00065042150
resolver
enst
ENSRNOT00000080585
resolver
enst
ENSRNOT00000120531
resolver
enst
ENSRNOT00055012429
resolver
enst
ENSRNOT00060011297
resolver
enst
ENSRNOT00065051209
resolver
genesymbol
Brd2
resolver
genesymbol_syn
Ring3
resolver
uniprot
A0A0G2K1Z8
resolver
uniprot_entry
A0A0G2K1Z8_RAT
resolver
uniprot_entry
BRD2_RAT
resolver
amino_acid_sequence
MLQNVTPHKLPGEGNAGLLGLGPEAAAPGKRIRKPSLLYEGFESPTMASVPALQLAPANPPPPEVSNPKKPGRVTNQLQYLHKVVMKALWKHQFAWPFRQPVDAVKLGLPDYHKIIKQPMDMGTIKRRLENNYYWAASECMQDFNTMFTNCYIYNKPTDDIVLMAQTLEKIFLQKVASMPQEEQELVVTIPKNSHKKGAKLAALQGSITSAHQVPAVSSVSHTALYTPPPEIPTTVLNIPHPSVISSPLLKSLHSAGPPLLAVSAAPPAQPLAKKKGVKRKADTTTPTPTAILAPGSPASPPGSLEPKAARLPPMRRESGRPIKPPRKDLPDSQQQHQSSKKGKLSEQLKHCNGILKELLSKKHAAYAWPFYKPVDASALGLHDYHDIIKHPMDLSTVKRKMENRDYRDAQEFAADVRLMFSNCYKYNPPDHDVVAMARKLQDVFEFRYAKMPDEPLEPGPLPVSTALPPGLAKSSSESSSEESSSESSSEEEEEEDEEDEEEESESSDSEEERAHRLAELQEQLRAVHEQLAALSQGPISKPKRKREKKEKKKKRKAEKHRGRIGIDEDDKGPRAPRPLQPKKSKKAGGGGSNATTLSHPGFGTSAGSSNKLPKKAQKTAPPVLPTGYDSEEEEESRPMSYDEKRQLSLDINKLPGEKLGRVVHIIQAREPSLRDSNPEEIEIDFETLKPSTLRELERYVLSCLRKKPRKPYTIRKPVGKTKEELALEKKRELEKRLQDVSGQLNSTKKPPKKASEKTESSAQQVAVSRLSASSSSSDSSSSSSSSSSSDTSDSDSG
uniprot
proteins
function
FUNCTION: Chromatin reader protein that specifically recognizes and binds histone H4 acetylated at 'Lys-5' and 'Lys-12' (H4K5ac and H4K12ac, respectively), thereby controlling gene expression and remodeling chromatin structures. Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation. Plays a key role in genome compartmentalization via its association with CTCF and cohesin: recruited to chromatin by CTCF and promotes formation of topologically associating domains (TADs) via its ability to bind acetylated histones, contributing to CTCF boundary formation and enhancer insulation. Also recognizes and binds acetylated non-histone proteins, such as STAT3. Involved in inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17: recognizes and binds STAT3 acetylated at 'Lys-87', promoting STAT3 recruitment to chromatin. In addition to acetylated lysines, also recognizes and binds lysine residues on histones that are both methylated and acetylated on the same side chain to form N6-acetyl-N6-methyllysine (Kacme), an epigenetic mark of active chromatin associated with increased transcriptional initiation. Specifically binds histone H4 acetyl-methylated at 'Lys-5' and 'Lys-12' (H4K5acme and H4K12acme, respectively). {ECO:0000250|UniProtKB:P25440}.
uniprot
proteins
mass_dalton
88051
uniprot
proteins
protein_family
BET family
uniprot
proteins
pubmed
15060004
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
798
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P25440}. Chromosome {ECO:0000250|UniProtKB:P25440}. Note=Detected on chromatin and nucleosomes. {ECO:0000250|UniProtKB:P25440}.
uniprot
proteins