Amot
entrez
27494
canonical
uniprot
Q8VHG2
canonical
ensembl
ENSMUSG00000041688
resolver
ensp
ENSMUSP00000108454
resolver
ensp
ENSMUSP00000108455
resolver
enst
ENSMUST00000112835
resolver
genesymbol
Amot
resolver
genesymbol_syn
Kiaa1071
resolver
uniprot
A0A067XG49
resolver
uniprot
A2AMJ9
resolver
uniprot
A2AMK0
resolver
uniprot
Q6PFB8
resolver
uniprot
Q6ZPZ1
resolver
uniprot_entry
A0A067XG49_MOUSE
resolver
uniprot_entry
AMOT_MOUSE
resolver
uniprot_sec
A2AMJ9
resolver
uniprot_sec
A2AMK0
resolver
uniprot_sec
Q6PFB8
resolver
uniprot_sec
Q6ZPZ1
resolver
amino_acid_sequence
MRSSDDQPSGGTTVLQRLLQEQLRYGNPSENRSLLAIHQQATGNSSPFSTGSGNQGPQNDVLSSQDHHQQQLVAHPARQEPQGQEIQSENGVMEKQLSPRMQNNEELPTYEEAKVQSQYFRGQQHASVGAAFYVTGVTNQKMRTEGRPSVQRLTPGKMHQDEGLRDLKQGHVRSLSERLMQMSLATSGVKAHPPVTSAPLSPPQPNDLYKNATSSSEFYKAQGPPPSQHSLKGMEHRGPPPEYPFKGVPSQSVVCKSQEPGHFYSEHRLNQPGRTEGQLMRYQHPPEYGAARATQDISSLSLSARNSQPHSPTSSLTAGASSLPLLQSPPSTRLPPGQHLVSNQGDHSAHLSRHQQHLLSSQSHQGDHYRHAQASLTSAQQQPGEAYSAMPRAQQSASYQPMPADPFAMVSRAQQMVEILSDENRNLRQELDGCYEKVARLQKVETEIQRVSEAYENLVKSSSKREALEKAMRNKLEGEIRRMHDFNRDLRDRLETANKQLAEKEYEGSEDTRKTISQLFAKHKENQREKEKLEAELATARSTNEDQRRHIEIRDQALSNAQAKVVKLEEELKKKQVYVDKVEKMQQALVQLQAACEKREQLEHRLRTRLERELESLRIQQRQGNSQPTNASEYNAAALMELLREKEERILALEADMTKWEQKYLEENVMRHFALDAAATVAAQRDTTVISHSPNTSYDTALEARIQKEEEEILMANKRCLDMEGRIKTLHAQIIEKDAMIKVLQQRSRKEPSKTEQLSSMRPAKSLMSISNAGSGLLAHSSTLTGAPIMEEKRDDKSWKGSLGVLLGGDYRVEPVPSTPSPVPPSTPLLSAHSKTGSRDCSTQTERGPESTKTAAVTPISAPMAGPVAAAAPAAAINATAATNTATAATNTTIMVAAAPVAVAAVAAPAAAAATPSPANAAALAAAAAPATSVSAATSVSAANSISPAAPVAPAAVVPPAAPVSPAAAVQIPAAASLTPATVSPTAATATAAVAAATTAAITAAAAAATTAIQVAPATSAPVPSPASIPAPATAQASAPTPTQASTPAPTEPPSPVPTPTPALVQTEGPANPGASSGPRRLSTPNLMCNPDKPDAPAFHSSTLERKTPIQILGQEPDAEMVEYLI
uniprot
proteins
function
FUNCTION: Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions (By similarity). Repressor of YAP1 and WWTR1/TAZ transcription of target genes, potentially via regulation of Hippo signaling-mediated phosphorylation of YAP1 which results in its recruitment to tight junctions (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q4VCS5}.
uniprot
proteins
mass_dalton
120915
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated by NEDD4, NEDD4L and ITCH, leading to proteasomal degradation. {ECO:0000250}.
uniprot
proteins
protein_family
Angiomotin family
uniprot
proteins
pubmed
12406577
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1126
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250}. Note=Localized on the cell surface. May act as a transmembrane protein (By similarity). {ECO:0000250}.
uniprot
proteins