AZIN1
entrez
51582
canonical
uniprot
O14977
canonical
ensembl
ENSG00000155096
resolver
ensp
ENSP00000321507
resolver
ensp
ENSP00000337180
resolver
ensp
ENSP00000506895
resolver
ensp
ENSP00000506898
resolver
ensp
ENSP00000507451
resolver
ensp
ENSP00000507850
resolver
ensp
ENSP00000508352
resolver
ensp
ENSP00000648238
resolver
ensp
ENSP00000648243
resolver
ensp
ENSP00000648252
resolver
ensp
ENSP00000758097
resolver
ensp
ENSP00000758109
resolver
enst
ENST00000337198
resolver
enst
ENST00000347770
resolver
enst
ENST00000681985
resolver
enst
ENST00000682725
resolver
enst
ENST00000683787
resolver
enst
ENST00000684566
resolver
genesymbol
AZIN1
resolver
genesymbol_syn
OAZI
resolver
genesymbol_syn
OAZIN
resolver
hgnc
HGNC:16432
resolver
uniprot
A0A804HLH4
resolver
uniprot
A6NCD5
resolver
uniprot
B3KTF6
resolver
uniprot
Q6IBQ7
resolver
uniprot
Q96D20
resolver
uniprot_entry
A0A804HLH4_HUMAN
resolver
uniprot_entry
AZIN1_HUMAN
resolver
uniprot_entry
B3KTF6_HUMAN
resolver
uniprot_sec
A6NCD5
resolver
uniprot_sec
Q6IBQ7
resolver
uniprot_sec
Q96D20
resolver
amino_acid_sequence
MKGFIDDANYSVGLLDEGTNLGNVIDNYVYEHTLTGKNAFFVGDLGKIVKKHSQWQNVVAQIKPFYTVKCNSAPAVLEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQIKYAAKVGVNILTCDNEIELKKIARNHPNAKVLLHIATEDNIGGEEGNMKFGTTLKNCRHLLECAKELDVQIIGVKFHVSSACKESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGFTGTEFQLEEVNHVISPLLDIYFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPSGVEKTGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPSCDELDQIVESCLLPELNVGDWLIFDNMGADSFHEPSAFNDFQRPAIYYMMSFSDWYEMQDAGITSDSMMKNFFFVPSCIQLSQEDSFSAEA
uniprot
proteins
function
FUNCTION: Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:17900240, PubMed:26305948). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:17900240). {ECO:0000269|PubMed:17900240, ECO:0000269|PubMed:26305948}.
uniprot
proteins
mass_dalton
49535
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, leading to its proteasomal degradation; a process that is reduced in presence of antizyme OAZ1. {ECO:0000269|PubMed:17900240}.
uniprot
proteins
protein_family
ODC antizyme inhibitor subfamily
uniprot
proteins
protein_family
Orn/Lys/Arg decarboxylase class-II family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
17900240
uniprot
proteins
pubmed
26305948
uniprot
proteins
pubmed
9349715
uniprot
proteins
sequence_length
448
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O35484}.
uniprot
proteins