Necab2
entrez
117148
canonical
uniprot
Q91ZP9
canonical
ensembl
ENSMUSG00000031837
resolver
ensp
ENSMUSP00000095966
resolver
genesymbol
Necab2
resolver
genesymbol_syn
Efcbp2
resolver
uniprot
Q1LZI4
resolver
uniprot
Q8C492
resolver
uniprot_entry
NECA2_MOUSE
resolver
uniprot_sec
Q1LZI4
resolver
uniprot_sec
Q8C492
resolver
amino_acid_sequence
MCERAARLCRAGAHRLLREPPPQGRALGGLLRWVGARMGEPRAPLVPDIPSADPGPGPAASRGGTAVILDIFRRADKNDDGKLSLEEFQLFFADGVLNEKELEGLFHTIDSDNTNHVDTKELCDYFVEHMGDYEDVLASLETLNHSVLKAMGYTKKVYEGGSNVDQFVTRFLLKETANQIQSLLSSVESAVEAIEEQTSQIRQDHCKPSHAVNESRYGGPTPPYIPNHKLVAPEPMKSLPVATGEPKEDGLEGQISRLAELIGRLESKTLSFDLQQRLSDEEGTNMHLQLVRQEMAVCPEQLSEFLDSLRQYLRSTAEERNCFHVAAVRMADGLTFVIYEFWETEEEWKRHLQSPVCKAFRHVKVDTLSQPEALSQISVPAAWCTSGRD
uniprot
proteins
function
FUNCTION: May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation. {ECO:0000250|UniProtKB:Q7Z6G3}.
uniprot
proteins
mass_dalton
43441
uniprot
proteins
pubmed
11641222
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
26843217
uniprot
proteins
sequence_length
389
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11641222}. Cell projection, dendrite {ECO:0000250|UniProtKB:F1LQY6}. Cell projection, axon {ECO:0000250|UniProtKB:F1LQY6}. Cell membrane {ECO:0000250|UniProtKB:Q7Z6G3}. Note=Colocalizes with ADORA2A and/or mGluR5/GRM5 at the plasma membrane (By similarity). Found in neuronal somata (PubMed:26843217). Detected in the cytoplasm of striatal neurons, at postsynaptic sites, filling dendritic shafts and spines, and at presynaptic sites, filling axon terminals (By similarity). {ECO:0000250|UniProtKB:F1LQY6, ECO:0000250|UniProtKB:Q7Z6G3, ECO:0000269|PubMed:26843217}.
uniprot
proteins