ECI1
entrez
1632
canonical
uniprot
P42126
canonical
ensembl
ENSG00000167969
resolver
ensp
ENSP00000301729
resolver
ensp
ENSP00000456319
resolver
genesymbol
ECI1
resolver
genesymbol_syn
DCI
resolver
hgnc
HGNC:2703
resolver
uniprot
A0A384NKJ3
resolver
uniprot
A8K512
resolver
uniprot
Q13290
resolver
uniprot
Q7Z2L6
resolver
uniprot
Q7Z2L7
resolver
uniprot
Q9BUB8
resolver
uniprot
Q9BW05
resolver
uniprot
Q9UDG6
resolver
uniprot_entry
A0A384NKJ3_HUMAN
resolver
uniprot_entry
ECI1_HUMAN
resolver
uniprot_sec
A8K512
resolver
uniprot_sec
Q13290
resolver
uniprot_sec
Q7Z2L6
resolver
uniprot_sec
Q7Z2L7
resolver
uniprot_sec
Q9BUB8
resolver
uniprot_sec
Q9BW05
resolver
uniprot_sec
Q9UDG6
resolver
amino_acid_sequence
MALVASVRVPARVLLRAGARLPGAALGRTERAAGGGDGARRFGSQRVLVEPDAGAGVAVMKFKNPPVNSLSLEFLTELVISLEKLENDKSFRGVILTSDRPGVFSAGLDLTEMCGRSPAHYAGYWKAVQELWLRLYQSNLVLVSAINGACPAGGCLVALTCDYRILADNPRYCIGLNETQLGIIAPFWLKDTLENTIGHRAAERALQLGLLFPPAEALQVGIVDQVVPEEQVQSTALSAIAQWMAIPDHARQLTKAMMRKATASRLVTQRDADVQNFVSFISKDSIQKSLQMYLERLKEEKG
uniprot
proteins
ec_number
5.3.3.8
uniprot
proteins
function
FUNCTION: Auxiliary enzyme in the beta-oxidation of mono- and polyunsaturated fatty acids (PubMed:26474213, PubMed:7818490). Together with the 2,4-dienoyl-CoA reductase (DECR) and the Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase (ECH1), they allow the reentrance of the enoyl-CoA into the beta-oxidation cycle (PubMed:26474213). Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of fatty enoyl-CoA species, with a preference for (3Z)-enoyl-CoAs over (3E)-enoyl-CoAs (PubMed:26474213, PubMed:7818490). The catalytic efficiency of this enzyme is not affected by the fatty acyl chain length, and based on its established catalytic mechanism, it is predicted to act also on other fatty acids besides those tested experimentally (By similarity). {ECO:0000250|UniProtKB:P23965, ECO:0000269|PubMed:7818490, ECO:0000303|PubMed:26474213}.
uniprot
proteins
mass_dalton
32816
uniprot
proteins
mutagenesis
MUTAGEN 178; /note="E->A: Loss of activity."; /evidence="ECO:0000269|PubMed:15351645
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid beta-oxidation. {ECO:0000269|PubMed:7818490}.
uniprot
proteins
protein_family
Enoyl-CoA hydratase/isomerase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15351645
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26474213
uniprot
proteins
pubmed
7818490
uniprot
proteins
pubmed
7829074
uniprot
proteins
pubmed
8198519
uniprot
proteins
sequence_length
302
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:P23965}.
uniprot
proteins