TRMT1L
entrez
81627
canonical
uniprot
Q7Z2T5
canonical
ensembl
ENSG00000121486
resolver
ensp
ENSP00000356476
resolver
genesymbol
TRMT1L
resolver
genesymbol_syn
C1orf25
resolver
genesymbol_syn
TRM1L
resolver
hgnc
HGNC:16782
resolver
uniprot
B4DXX1
resolver
uniprot
Q5TEN0
resolver
uniprot
Q6ZMX0
resolver
uniprot
Q8IWH5
resolver
uniprot
Q8NC68
resolver
uniprot
Q9BZQ1
resolver
uniprot_entry
B4DXX1_HUMAN
resolver
uniprot_entry
TRM1L_HUMAN
resolver
uniprot_sec
Q5TEN0
resolver
uniprot_sec
Q6ZMX0
resolver
uniprot_sec
Q8IWH5
resolver
uniprot_sec
Q8NC68
resolver
uniprot_sec
Q9BZQ1
resolver
amino_acid_sequence
MENMAEEELLPLEKEEVEVAQVQVPTPARDSAGVPAPAPDSALDSAPTPASAPAPAPALAQAPALSPSLASAPEEAKSKRHISIQRQLADLENLAFVTDGNFDSASSLNSDNLDAGNRQACPLCPKEKFRACNSHKLRRHLQNLHWKVSVEFEGYRMCICHLPCRPVKPNIIGEQITSKMGAHYHCIICSATITRRTDMLGHVRRHMNKGETKSSYIAASTAKPPKEILKEADTDVQVCPNYSIPQKTDSYFNPKMKLNRQLIFCTLAALAEERKPLECLDAFGATGIMGLQWAKHLGNAVKVTINDLNENSVTLIQENCHLNKLKVVVDSKEKEKSDDILEEGEKNLGNIKVTKMDANVLMHLRSFDFIHLDPFGTSVNYLDSAFRNIRNLGIVSVTSTDISSLYAKAQHVARRHYGCNIVRTEYYKELAARIVVAAVARAAARCNKGIEVLFAVALEHFVLVVVRVLRGPTSADETAKKIQYLIHCQWCEERIFQKDGNMVEENPYRQLPCNCHGSMPGKTAIELGPLWSSSLFNTGFLKRMLFESLHHGLDDIQTLIKTLIFESECTPQSQFSIHASSNVNKQEENGVFIKTTDDTTTDNYIAQGKRKSNEMITNLGKKQKTDVSTEHPPFYYNIHRHSIKGMNMPKLKKFLCYLSQAGFRVSRTHFDPMGVRTDAPLMQFKSILLKYSTPTYTGGQSESHVQSASEDTVTERVEMSVNDKAEASGCRRW
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Specifically dimethylates a single guanine residue at position 27 of tRNA(Tyr) using S-adenosyl-L-methionine as donor of the methyl groups (PubMed:39786990, PubMed:39786998). Dimethylation at position 27 of tRNA(Tyr) is required for efficient translation of tyrosine codons (PubMed:39786990, PubMed:39786998). Also required to maintain 3-(3-amino-3-carboxypropyl)uridine (acp3U) in the D-loop of several cytoplasmic tRNAs (PubMed:39786990, PubMed:39786998). {ECO:0000269|PubMed:39786990, ECO:0000269|PubMed:39786998}.
uniprot
proteins
mass_dalton
81747
uniprot
proteins
mutagenesis
MUTAGEN 135..139; /note="HKLRR->AAAA: Abolished nucleolar localization."; /evidence="ECO:0000269|PubMed:39786998"; MUTAGEN 373; /note="D->A: Abolished tRNA guanine-dimethyltransferase activity."; /evidence="ECO:0000269|PubMed:39786990
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
Trm1 family
uniprot
proteins
pubmed
11318611
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28784718
uniprot
proteins
pubmed
33499731
uniprot
proteins
pubmed
39786990
uniprot
proteins
pubmed
39786998
uniprot
proteins
sequence_length
733
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:28784718, ECO:0000269|PubMed:39786998, ECO:0000305|PubMed:33499731}.
uniprot
proteins