Fndc5
entrez
384061
canonical
uniprot
Q8K4Z2
canonical
ensembl
ENSMUSG00000001334
resolver
ensp
ENSMUSP00000099660
resolver
ensp
ENSMUSP00000240438
resolver
genesymbol
Fndc5
resolver
genesymbol_syn
Frcp2
resolver
genesymbol_syn
Pep
resolver
uniprot
A0AA74KUW2
resolver
uniprot
Q9DB97
resolver
uniprot_entry
FNDC5_MOUSE
resolver
uniprot_sec
A0AA74KUW2
resolver
uniprot_sec
Q9DB97
resolver
amino_acid_sequence
MQAARGGAGRPGREGRGLERECERSPGPGVAMPPGPCAWPPRAALRLWLGCVCFALVQADSPSAPVNVTVRHLKANSAVVSWDVLEDEVVIGFAISQQKKDVRMLRFIQEVNTTTRSCALWDLEEDTEYIVHVQAISIQGQSPASEPVLFKTPREAEKMASKNKDEVTMKEMGRNQQLRTGEVLIIVVVLFMWAGVIALFCRQYDIIKDNEPNNNKEKTKSASETSTPEHQGGGLLRSKI
uniprot
proteins
function
FUNCTION: [Irisin]: Mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA. {ECO:0000269|PubMed:22237023}.
uniprot
proteins
mass_dalton
26468
uniprot
proteins
post_translational_modification
PTM: The extracellular domain is cleaved and released from the cell membrane. {ECO:0000269|PubMed:22237023}.; PTM: N-Glycosylated. {ECO:0000269|PubMed:22237023}.
uniprot
proteins
pubmed
12112469
uniprot
proteins
pubmed
12384288
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22237023
uniprot
proteins
pubmed
38471509
uniprot
proteins
sequence_length
240
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Fibronectin type III domain-containing protein 5]: Cell membrane {ECO:0000250|UniProtKB:Q8NAU1}; Single-pass membrane protein {ECO:0000255}. Peroxisome membrane {ECO:0000269|PubMed:12112469}; Single-pass membrane protein {ECO:0000255}. Note=Imported into peroxisomes through the PEX5 receptor pathway. {ECO:0000269|PubMed:12112469}.; SUBCELLULAR LOCATION: [Irisin]: Secreted {ECO:0000269|PubMed:22237023}. Note=Detected in plasma following endurance exercise. {ECO:0000269|PubMed:22237023}.
uniprot
proteins
transmembrane_region
TRANSMEM 181..201; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins