Ncf4
entrez
17972
canonical
uniprot
P97369
canonical
ensembl
ENSMUSG00000071715
resolver
ensp
ENSMUSP00000094084
resolver
ensp
ENSMUSP00000241654
resolver
ensp
ENSMUSP00000354500
resolver
enst
ENSMUST00000096357
resolver
genesymbol
Ncf4
resolver
uniprot
Q3TBC6
resolver
uniprot_entry
NCF4_MOUSE
resolver
uniprot_sec
Q3TBC6
resolver
amino_acid_sequence
MALAQQLRSESDFEQLPDDVAVSANIADIEEKRGFTSHFVFVIEVKTKGGSKYLIYRRYRQFYALQSKLEERFGPESKNSPFTCSLPTLPAKVYMGAKQEIAETRIPALNAYMKNLLSLPVCVLMDPDVRIFFYQSAYDAEQVPQALRRLRPRTRKIKGVSPQGAIMDRMEAPRAEALFDFTGNSKLELSFKAGDVIFLLSKINKDWLEGTSQGATGIFPGSFVKILKDFPEDEDTTNWLRCYFYEDTGKTIKDIAVEEDLSSTPLFKDLLALMRREFQREDIALSYQDAEGDLVRLLSDEDVGLMVKQARGLPSQKRLFPWKLHVTQKDNYSVYNTVP
uniprot
proteins
function
FUNCTION: Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (By similarity). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction. Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (By similarity). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (By similarity). {ECO:0000250|UniProtKB:P04839, ECO:0000250|UniProtKB:P14598, ECO:0000250|UniProtKB:Q15080}.
uniprot
proteins
mass_dalton
38707
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21551061
uniprot
proteins
pubmed
8995189
uniprot
proteins
pubmed
9490028
uniprot
proteins
sequence_length
339
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q15080}. Endosome membrane {ECO:0000250|UniProtKB:Q15080}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q15080}; Cytoplasmic side {ECO:0000250|UniProtKB:Q15080}. Membrane {ECO:0000250|UniProtKB:Q15080}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q15080}. Note=Translocates to the membrane upon activation by phorbol myristate acetate (PMA). {ECO:0000250|UniProtKB:Q15080}.
uniprot
proteins