Acly
entrez
104112
canonical
uniprot
Q91V92
canonical
ensembl
ENSMUSG00000020917
resolver
ensp
ENSMUSP00000007131
resolver
ensp
ENSMUSP00000103012
resolver
ensp
ENSMUSP00000127632
resolver
enst
ENSMUST00000007131
resolver
enst
ENSMUST00000107389
resolver
enst
ENSMUST00000165111
resolver
genesymbol
Acly
resolver
uniprot
F6W1W7
resolver
uniprot
Q3V117
resolver
uniprot_entry
ACLY_MOUSE
resolver
uniprot_entry
F6W1W7_MOUSE
resolver
uniprot_entry
Q3V117_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Phosphorylation results in activation of its activity (By similarity). Glucose 6-phosphate, fructose 6-phosphate, fructose 2,6-bisphosphate, ribulose 5-phosphate, and fructose 1,6-bisphosphate also act as activators (By similarity). {ECO:0000250|UniProtKB:P53396}.
uniprot
proteins
amino_acid_sequence
MSAKAISEQTGKELLYKYICTTSAIQNRFKYARVTPDTDWAHLLQDHPWLLSQSLVVKPDQLIKRRGKLGLVGVNLSLDGVKSWLKPRLGHEATVGKAKGFLKNFLIEPFVPHSQAEEFYVCIYATREGDYVLFHHEGGVDVGDVDAKAQKLLVGVDEKLNTEDIKRHLLVHAPEDKKEVLASFISGLFNFYEDLYFTYLEINPLVVTKDGVYILDLAAKVDATADYICKVKWGDIEFPPPFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNELANYGEYSGAPSEQQTYDYAKTILSLMTREKHPEGKILIIGGSIANFTNVAATFKGIVRAIRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQGKSATLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMKKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPVVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVAKGAIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQRRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDFVKQHFPATPLLDYALEVEKITTSKKPNLILNVDGFIGVAFVDMLRNCGSFTREEADEYVDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWDDISYVLPEHMSM
uniprot
proteins
ec_number
2.3.3.8
uniprot
proteins
function
FUNCTION: Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate in multiple biochemical reactions in protein, carbohydrate and lipid metabolism. {ECO:0000269|PubMed:25450640}.
uniprot
proteins
mass_dalton
119728
uniprot
proteins
mutagenesis
MUTAGEN 530; /note="K->R: Abolished ubiquitination by the BCR(KLHL25)complex, leading to imapired differentiation of inducible regulatory T (iTreg) cells; when associated with R-536 and R-544."; /evidence="ECO:0000269|PubMed:34491895"; MUTAGEN 536; /note="K->R: Abolished ubiquitination by the BCR(KLHL25)complex, leading to imapired differentiation of inducible regulatory T (iTreg) cells; when associated with R-530 and R-544."; /evidence="ECO:0000269|PubMed:34491895"; MUTAGEN 544; /note="K->R: Abolished ubiquitination by the BCR(KLHL25)complex, leading to imapired differentiation of inducible regulatory T (iTreg) cells; when associated with R-530 and R-536."; /evidence="ECO:0000269|PubMed:34491895
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKA and GSK3 in a sequential manner; phosphorylation results in activation of its activity (By similarity). Phosphorylation on Thr-447 and Ser-451 depends on the phosphorylation state of Ser-455 (By similarity). Phosphorylation on Ser-455 is decreased by prior phosphorylation on the other 2 residues (By similarity). Phosphorylated at Ser-455 by BCKDK and dephosphorylated by protein phosphatase PPM1K. {ECO:0000250|UniProtKB:P16638, ECO:0000250|UniProtKB:P53396}.; PTM: ISGylated. {ECO:0000269|PubMed:16139798}.; PTM: Acetylated at Lys-530, Lys-536 and Lys-544 by KAT2B/PCAF (By similarity). Acetylation is promoted by glucose and stabilizes the protein, probably by preventing ubiquitination at the same sites (By similarity). Acetylation promotes de novo lipid synthesis (By similarity). Deacetylated by SIRT2 (By similarity). {ECO:0000250|UniProtKB:P53396}.; PTM: Ubiquitinated at Lys-530, Lys-536 and Lys-544 by the BCR(KLHL25) E3 ubiquitin ligase complex and UBR4, leading to its degradation (PubMed:34491895). Ubiquitination is probably inhibited by acetylation at same site (By similarity). BCR(KLHL25)-mediated degradation of ACLY promotes fatty acid oxidation and is required for differentiation of inducible regulatory T (iTreg) cells (PubMed:34491895). {ECO:0000250|UniProtKB:P53396, ECO:0000269|PubMed:34491895}.; PTM: Benzoylated at Lys-968. Debenzoylated by SIRT3; inhibiting the ATP-citrate synthase activity. {ECO:0000250|UniProtKB:P53396}.
uniprot
proteins
protein_family
Succinate/malate CoA ligase beta subunit family; Succinate/malate CoA ligase alpha subunit family
uniprot
proteins
pubmed
11471062
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16139798
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
25450640
uniprot
proteins
pubmed
34491895
uniprot
proteins
sequence_length
1091
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P53396}.
uniprot
proteins