PARVA
entrez
55742
canonical
uniprot
Q9NVD7
canonical
ensembl
ENSG00000197702
resolver
ensp
ENSP00000334008
resolver
genesymbol
PARVA
resolver
genesymbol_syn
MXRA2
resolver
hgnc
HGNC:14652
resolver
uniprot
Q96C85
resolver
uniprot
Q9HA48
resolver
uniprot_entry
PARVA_HUMAN
resolver
uniprot_sec
Q96C85
resolver
uniprot_sec
Q9HA48
resolver
amino_acid_sequence
MATSPQKSPSVPKSPTPKSPPSRKKDDSFLGKLGGTLARRKKAKEVSELQEEGMNAINLPLSPIPFELDPEDTMLEENEVRTMVDPNSRSDPKLQELMKVLIDWINDVLVGERIIVKDLAEDLYDGQVLQKLFEKLESEKLNVAEVTQSEIAQKQKLQTVLEKINETLKLPPRSIKWNVDSVHAKSLVAILHLLVALSQYFRAPIRLPDHVSIQVVVVQKREGILQSRQIQEEITGNTEALSGRHERDAFDTLFDHAPDKLNVVKKTLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEGYFVPLHSFFLTPDSFEQKVLNVSFAFELMQDGGLEKPKPRPEDIVNCDLKSTLRVLYNLFTKYRNVE
uniprot
proteins
function
FUNCTION: Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration. Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration (PubMed:30367047). {ECO:0000250, ECO:0000269|PubMed:11134073, ECO:0000269|PubMed:11331308, ECO:0000269|PubMed:15284246, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:30367047}.
uniprot
proteins
mass_dalton
42244
uniprot
proteins
mutagenesis
MUTAGEN 4; /note="S->D: Loss of interaction with TESK1, however no effect on interaction with ILK; when associated with D-8."; /evidence="ECO:0000269|PubMed:15817463"; MUTAGEN 8; /note="S->D: Loss of interaction with TESK1, however no effect on interaction with ILK; when associated with D-4."; /evidence="ECO:0000269|PubMed:15817463"; MUTAGEN 37..42; /note="LARRKK->AAAAAA: Reduced actin binding."; /evidence="ECO:0000269|PubMed:30367047"; MUTAGEN 271; /note="F->D: Loss of interaction with ILK. Loss of localization to focal adhesions."; /evidence="ECO:0000269|PubMed:11331308
uniprot
proteins
protein_family
Parvin family
uniprot
proteins
pubmed
11134073
uniprot
proteins
pubmed
11171322
uniprot
proteins
pubmed
11331308
uniprot
proteins
pubmed
11722847
uniprot
proteins
pubmed
12432066
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15242332
uniprot
proteins
pubmed
15284246
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15817463
uniprot
proteins
pubmed
16860736
uniprot
proteins
pubmed
18508764
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
18940607
uniprot
proteins
pubmed
20005845
uniprot
proteins
pubmed
20393563
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22441983
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
30367047
uniprot
proteins
pubmed
35259013
uniprot
proteins
sequence_length
372
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000269|PubMed:11331308, ECO:0000269|PubMed:35259013}. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}.
uniprot
proteins