Ncln
entrez
314648
canonical
uniprot
Q5XIA1
canonical
ensembl
ENSRNOG00000004793
resolver
ensp
ENSRNOP00000077163
resolver
enst
ENSRNOT00000094550
resolver
genesymbol
Ncln
resolver
uniprot_entry
NCLN_RAT
resolver
amino_acid_sequence
MLEEAGEVLENVLKASCLPLGFIVFLPAVLLLVAPPLPAADAAHEFTVYRMQQYDLQGQPYGTRNAVLNTEARTVDADVLSRRCVLMRLLDFSYEHYQKALRQSAGAVVIILPRAMAAVPQDVVRQFMEIEPEMLAMETVVPVYFAVEDEALLSIYEQTQAASASQGSASAAEVLLHTATANGFQMVTSGAQSQAVSDWLITSVEGRLTGLGGEDLPTIVIVAHYDAFGVAPWLSLGADSNGSGISVLLELARLFSRLYTYKRTHAAYNLLFFASGGGKFNYQGTKRWLEDSLDHTDSSLLQDNVAFVLCLDTVGRGSHLRLHVSKPPREGTLQHVFLRELEMVAAHQFPDVSFSMVHKKINLADDVLAWEHERFAIRRLPAFTLSHLENHRAGPRSSIMDVRSRVDSKTLTRNTRIIAEALTRVIYNLTEKGTPPDMPVFTEQMQVQQEQIDSVMDWLTNQPRAAQLLDKDGTFLSTLEHFLSRYLKDVRQHHVKADKRDPEFVFYDQLKQVMNAYRVKPAIFDLLLALCIGAYLGMAYTAVQHFHVLYKTVQRLLLKAKAQ
uniprot
proteins
function
FUNCTION: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (By similarity). May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NOMO (By similarity). {ECO:0000250|UniProtKB:Q6NZ07, ECO:0000250|UniProtKB:Q969V3}.
uniprot
proteins
mass_dalton
62992
uniprot
proteins
protein_family
Nicastrin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
563
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q969V3}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q969V3}.
uniprot
proteins
transmembrane_region
TRANSMEM 523..543; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins