Hsp90b1
entrez
22027
canonical
uniprot
P08113
canonical
ensembl
ENSMUSG00000020048
resolver
ensp
ENSMUSP00000020238
resolver
enst
ENSMUST00000020238
resolver
genesymbol
Hsp90b1
resolver
genesymbol_syn
Grp94
resolver
genesymbol_syn
Hspc4
resolver
genesymbol_syn
Tra-1
resolver
genesymbol_syn
Tra1
resolver
uniprot
P11427
resolver
uniprot
Q3UAD6
resolver
uniprot_entry
ENPL_MOUSE
resolver
uniprot_entry
Q3UAD6_MOUSE
resolver
uniprot_sec
P11427
resolver
amino_acid_sequence
MRVLWVLGLCCVLLTFGFVRADDEVDVDGTVEEDLGKSREGSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQAEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLISLTDENALAGNEELTVKIKCDKEKNLLHVTDTGVGMTREELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFGVGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIADPRGNTLGRGTTITLVLKEEASDYLELDTIKNLVRKYSQFINFPIYVWSSKTETVEEPLEEDEAAKEEKEESDDEAAVEEEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEEDEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPTSAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYLNFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTLDMIKKIADEKYNDTFWKEFGTNIKLGVIEDHSNRTRLAKLLRFQSSHHSTDITSLDQYVERMKEKQDKIYFMAGSSRKEAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGKRFQNVAKEGVKFDESEKTKESREATEKEFEPLLNWMKDKALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKAQAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKEDEDDKTVMDLAVVLFETATLRSGYLLPDTKAYGDRIERMLRLSLNIDPEAQVEEEPEEEPEDTSEDAEDSEQDEGEEMDAGTEEEEEETEKESTEKDEL
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:20865800, PubMed:23572575). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:20865800). Promotes folding and trafficking of TLR4 to the cell surface (By similarity). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (By similarity). {ECO:0000250|UniProtKB:P14625, ECO:0000269|PubMed:20865800, ECO:0000269|PubMed:23572575}.
uniprot
proteins
mass_dalton
92476
uniprot
proteins
mutagenesis
MUTAGEN 103; /note="E->A: Loss of CNPY3-binding."; /evidence="ECO:0000269|PubMed:20865800
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CK2. {ECO:0000250|UniProtKB:P41148}.; PTM: N-glycosylated cotranslationally at Asn-217 by STT3A-containing OST-A complex: this glycosylation is constitutive (PubMed:8179819). In response to various stress, 5 additional facultative sites (Asn-62, Asn-107, Asn-445, Asn-481 and Asn-502) can be glycosylated post-translationally by STT3B-containing OST-B complex, leading to a hyperglycosylated form that is degraded by the ER-associated degradation (ERAD) pathway (By similarity). In normal conditions, the OST-A complex together with CCDC134 prevent glycosylation at facultative sites during protein folding, thereby preventing hyperglycosylation (By similarity). Mechanistically, nascent HSP90B1 is tethered during translation to a specialized CCDC134-containing translocon that forms a microenvironment for its folding, in which STT3A associates with the SRT pseudosubstrate motif, and prevents access to facultative glycosylation sites until folding is completed, rendering its facultative sites inaccessible to the OST-B complex (By similarity). {ECO:0000250|UniProtKB:P14625, ECO:0000269|PubMed:8179819}.
uniprot
proteins
protein_family
Heat shock protein 90 family
uniprot
proteins
pubmed
12475965
uniprot
proteins
pubmed
16931514
uniprot
proteins
pubmed
17525271
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
20865800
uniprot
proteins
pubmed
21093319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23572575
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
2438686
uniprot
proteins
pubmed
2768254
uniprot
proteins
pubmed
3036833
uniprot
proteins
pubmed
3612811
uniprot
proteins
pubmed
8179819
uniprot
proteins
sequence_length
802
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:20865800}. Sarcoplasmic reticulum lumen {ECO:0000250|UniProtKB:P41148}. Melanosome {ECO:0000250|UniProtKB:P14625}.
uniprot
proteins