Rab11a
entrez
81830
canonical
uniprot
P62494
canonical
ensembl
ENSRNOG00000011302
resolver
ensembl
ENSRNOG00055024661
resolver
ensembl
ENSRNOG00060020490
resolver
ensembl
ENSRNOG00065006474
resolver
ensp
ENSRNOP00000015598
resolver
ensp
ENSRNOP00000079481
resolver
ensp
ENSRNOP00055034730
resolver
ensp
ENSRNOP00060029272
resolver
ensp
ENSRNOP00065007285
resolver
enst
ENSRNOT00000015598
resolver
enst
ENSRNOT00000115583
resolver
enst
ENSRNOT00055042525
resolver
enst
ENSRNOT00060035605
resolver
enst
ENSRNOT00065010010
resolver
genesymbol
Rab11a
resolver
genesymbol_syn
Rab11
resolver
uniprot
A0A8I5ZN41
resolver
uniprot
P24410
resolver
uniprot
Q9JLX1
resolver
uniprot_entry
A0A8I5ZN41_RAT
resolver
uniprot_entry
RB11A_RAT
resolver
uniprot_sec
P24410
resolver
uniprot_sec
Q9JLX1
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) including SH3BP5, which promote the exchange of bound GDP for free GTP (By similarity). Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs) which prevent Rab-GDP dissociation. {ECO:0000250|UniProtKB:P62491, ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEARAFAEKNGLSFIETSALDSTNVEAAFQTILTEIYRIVSQKQMSDRRENDMSPSNNVVPIHVPPTTENKPKVQCCQNI
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB11A regulates endocytic recycling (PubMed:11163216). Forms a functional Rab11/RAB11FIP3/dynein complex that regulates the movement of peripheral sorting endosomes (SE) along microtubule tracks toward the microtubule organizing center/centrosome, generating the endosomal recycling compartment (ERC). Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with Rabin8/RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane (By similarity). Regulates the recycling of FCGRT (receptor of Fc region of monomeric IgG) to basolateral membranes (By similarity). May also play a role in melanosome transport and release from melanocytes (By similarity). Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation. On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth. Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-endososomal dependent export route via interaction with WDR44 (By similarity). Also interacts with RABL3 to promote ciliary vesicle formation (By similarity). {ECO:0000250|UniProtKB:P62490, ECO:0000250|UniProtKB:P62491, ECO:0000250|UniProtKB:P62492, ECO:0000269|PubMed:11163216}.
uniprot
proteins
mass_dalton
24394
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
11163216
uniprot
proteins
pubmed
12145319
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17082457
uniprot
proteins
pubmed
1711847
uniprot
proteins
pubmed
20826437
uniprot
proteins
sequence_length
216
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P62491}; Lipid-anchor {ECO:0000250|UniProtKB:P62491}. Endosome membrane {ECO:0000250|UniProtKB:P62491}; Lipid-anchor {ECO:0000250|UniProtKB:P62491}. Recycling endosome membrane {ECO:0000250|UniProtKB:P62491}; Lipid-anchor {ECO:0000250|UniProtKB:P62491}. Cleavage furrow {ECO:0000250|UniProtKB:P62491}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:P62491}; Lipid-anchor {ECO:0000250|UniProtKB:P62491}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P62491}; Lipid-anchor {ECO:0000250|UniProtKB:P62491}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:P62491}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P62491}; Lipid-anchor {ECO:0000250|UniProtKB:P62491}. Cell projection, cilium {ECO:0000250|UniProtKB:P62491}. Note=Localized to WDR44-positive endosomes and tubules. Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. During interphase, localized in vesicles continuously moving from peripheral sorting endosomes towards the pericentrosomal ERC. Localizes to the cleavage furrow. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB8A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis. Recruited to phagosomes containing S.aureus or M.tuberculosis. Localized to rhodopsin transport carriers when interacting with RAB11AFIP3 and ASAP1 in photoreceptors. Colocalizes with RAB11AFIP1 on punctate vesicles. {ECO:0000250|UniProtKB:P62491}.
uniprot
proteins