Gckr
entrez
25658
canonical
uniprot
Q07071
canonical
ensembl
ENSRNOG00000048874
resolver
ensembl
ENSRNOG00055018634
resolver
ensembl
ENSRNOG00060013089
resolver
ensp
ENSRNOP00000064260
resolver
ensp
ENSRNOP00055025646
resolver
ensp
ENSRNOP00060017703
resolver
enst
ENSRNOT00000073228
resolver
enst
ENSRNOT00055031719
resolver
enst
ENSRNOT00060022320
resolver
genesymbol
Gckr
resolver
uniprot_entry
GCKR_RAT
resolver
amino_acid_sequence
MPGTKRYQHVIETPEPGEWELSGYEAAVPITEKSNPLTRNLDKADAEKIVKLLGQCDAEIFQEEGQIVPTYQRLYSESVLTTMLQVAGKVQEVLKEPDGGLVVLSGGGTSGRMAFLMSVSFNQLMKGLGQKPLYTYLIAGGDRSVVASREQTEDSALHGIEELKKVAAGKKRVVVIGISVGLSAPFVAGQMDYCMDNTAVFLPVLVGFNPVSMARNDPIEDWRSTFRQVAERMQKMQEKQEAFVLNPAIGPEGLSGSSRMKGGGATKILLETLLLAAHKTVDQGVVSSQRCLLEILRTFERAHQVTYSQSSKIATLMKQVGISLEKKGRVHLVGWQTLGIIAIMDGVECIHTFGADFQDIRGFLIGDHSDMFNQKDELTNQGPQFTFSQDDFLTSILPSLTETDTVVFIFTLDDNLTEVQALAERVREKCQNIQALVHSTVGQSLPAPLKKLFPSLISITWPLLFFDYEGTYVQKFQRELSTKWVLNTVSTGAHVLLGKILQNHMLDLRIANSKLFWRALAMLQRFSGQSKARCIESLLQAIHFPQPLSDDVRAAPISCHVQVAHEKEKVIPTALLSLLLRCSISEAKARLSAASSVCEVVRSALSGPGQKRSTQALEDPPACGTLN
uniprot
proteins
function
FUNCTION: Regulates glucokinase (GCK) by forming an inactive complex with this enzyme (PubMed:23957911). Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal (PubMed:10456334). The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity (PubMed:23957911). {ECO:0000269|PubMed:10456334, ECO:0000269|PubMed:23957911}.
uniprot
proteins
mass_dalton
68917
uniprot
proteins
protein_family
GCKR family
uniprot
proteins
pubmed
10456334
uniprot
proteins
pubmed
10518020
uniprot
proteins
pubmed
10601273
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16542652
uniprot
proteins
pubmed
23957911
uniprot
proteins
pubmed
7682971
uniprot
proteins
pubmed
8112473
uniprot
proteins
sequence_length
627
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10456334, ECO:0000269|PubMed:10518020, ECO:0000269|PubMed:16542652}. Nucleus {ECO:0000269|PubMed:10456334, ECO:0000269|PubMed:10601273}. Mitochondrion {ECO:0000269|PubMed:16542652}. Note=Under low glucose concentrations, GCKR associates with GCK and the inactive complex is recruited to the hepatocyte nucleus. {ECO:0000269|PubMed:10456334}.
uniprot
proteins