SNRPD1
entrez
6632
canonical
uniprot
P62314
canonical
ensembl
ENSG00000167088
resolver
ensp
ENSP00000300413
resolver
ensp
ENSP00000626769
resolver
enst
ENST00000300413
resolver
genesymbol
SNRPD1
resolver
hgnc
HGNC:11158
resolver
uniprot
B5BTZ1
resolver
uniprot
P13641
resolver
uniprot_entry
SMD1_HUMAN
resolver
uniprot_sec
B5BTZ1
resolver
uniprot_sec
P13641
resolver
amino_acid_sequence
MKLVRFLMKLSHETVTIELKNGTQVHGTITGVDVSMNTHLKAVKMTLKNREPVQLETLSIRGNNIRYFILPDSLPLDTLLVDVEPKVKSKKREAVAGRGRGRGRGRGRGRGRGRGGPRR
uniprot
proteins
function
FUNCTION: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077). May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA (PubMed:23333303). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:23333303, ECO:0000269|PubMed:25555158, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:32494006, ECO:0000305|PubMed:23333303}.
uniprot
proteins
mass_dalton
13282
uniprot
proteins
mutagenesis
MUTAGEN 58; /note="L->K: Loss of interaction with CLNS1A."; /evidence="ECO:0000269|PubMed:11747828"; MUTAGEN 60; /note="I->R: Loss of interaction with CLNS1A."; /evidence="ECO:0000269|PubMed:11747828
uniprot
proteins
post_translational_modification
PTM: Methylated on arginine residues by PRMT5 and PRMT7; probable asymmetric dimethylation which is required for assembly and biogenesis of snRNPs. {ECO:0000269|PubMed:11747828, ECO:0000269|PubMed:17709427}.
uniprot
proteins
protein_family
SnRNP core protein family
uniprot
proteins
pubmed
10025403
uniprot
proteins
pubmed
10500148
uniprot
proteins
pubmed
11135666
uniprot
proteins
pubmed
11747828
uniprot
proteins
pubmed
11991638
uniprot
proteins
pubmed
15146077
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16314521
uniprot
proteins
pubmed
17709427
uniprot
proteins
pubmed
18984161
uniprot
proteins
pubmed
19054851
uniprot
proteins
pubmed
19325628
uniprot
proteins
pubmed
21113136
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21516107
uniprot
proteins
pubmed
21816274
uniprot
proteins
pubmed
23333303
uniprot
proteins
pubmed
2528429
uniprot
proteins
pubmed
25555158
uniprot
proteins
pubmed
26912367
uniprot
proteins
pubmed
28076346
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28502770
uniprot
proteins
pubmed
28781166
uniprot
proteins
pubmed
31799625
uniprot
proteins
pubmed
32494006
uniprot
proteins
pubmed
3260384
uniprot
proteins
pubmed
33509932
uniprot
proteins
pubmed
36797247
uniprot
proteins
sequence_length
119
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:21113136, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. {ECO:0000305}.
uniprot
proteins