Siglec12
entrez
83382
canonical
uniprot
Q91Y57
canonical
ensembl
ENSMUSG00000030474
resolver
ensp
ENSMUSP00000032667
resolver
ensp
ENSMUSP00000322621
resolver
ensp
ENSMUSP00000322622
resolver
ensp
ENSMUSP00000322623
resolver
enst
ENSMUST00000032667
resolver
genesymbol
Siglec12
resolver
genesymbol_syn
Siglec5
resolver
genesymbol_syn
Siglece
resolver
genesymbol_syn
Siglecl1
resolver
uniprot
E9QMD1
resolver
uniprot_entry
SIG12_MOUSE
resolver
uniprot_sec
E9QMD1
resolver
amino_acid_sequence
MLLLLLLLLLWGIKGVEGQNPQEVFTLNVERKVVVQEGLCVLVPCNFSYLKKRLTDWTDSDPVHGFWYREGTDRRKDSIVATNNPIRKAVKETRNRFFLLGDPWRNDCSLNIREIRKKDAGLYFFRLERGKTKYNYMWDKMTLVVTALTNTPQILLPETLEAGHPSNLTCSVPWDCGWTAPPIFSWTGTSVSFLSTNTTGSSVLTITPQPQDHGTNLTCQVTLPGTNVSTRMTIRLNVSYAPKNLTVTIYQGADSVSTILKNGSSLPISEGQSLRLICSTDSYPPANLSWSWDNLTLCPSKLSKPGLLELFPVHLKHGGVYTCQAQHALGSQHISLSLSPQSSATLSEMMMGTFVGSGVTALLFLSVCILLLAVRSYRRKPARPAVVAPHPDALKVSVSQNPLVESQADDSSEPLPSILEAAPSSTEEEIHYATLSFHEMKPMNLWGQQDTTTEYSEIKFPQRTAWP
uniprot
proteins
function
FUNCTION: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
uniprot
proteins
mass_dalton
51901
uniprot
proteins
mutagenesis
MUTAGEN 432; /note="Y->F: Abolishes binding to PTPN6 and PTPN11."; /evidence="ECO:0000269|PubMed:11171044, ECO:0000269|PubMed:11278955"; MUTAGEN 455; /note="Y->F: Reduces binding to PTPN6."; /evidence="ECO:0000269|PubMed:11171044, ECO:0000269|PubMed:11278955
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Tyr-432 is required for binding to PTPN6 and PTPN11. Phosphorylation of Tyr-455 is involved in binding to PTPN6. Tyr-432 needs to be phosphorylated prior to Tyr-455. {ECO:0000269|PubMed:11171044, ECO:0000269|PubMed:11278955}.
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
protein_family
SIGLEC (sialic acid binding Ig-like lectin) family
uniprot
proteins
pubmed
11171044
uniprot
proteins
pubmed
11278955
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
467
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 354..374; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins