MTUS1
entrez
57509
canonical
uniprot
Q9ULD2
canonical
ensembl
ENSG00000129422
resolver
ensp
ENSP00000262102
resolver
ensp
ENSP00000297488
resolver
ensp
ENSP00000371285
resolver
ensp
ENSP00000371293
resolver
ensp
ENSP00000445738
resolver
ensp
ENSP00000489288
resolver
ensp
ENSP00000509719
resolver
ensp
ENSP00000587915
resolver
ensp
ENSP00000665052
resolver
ensp
ENSP00000665053
resolver
ensp
ENSP00000665054
resolver
genesymbol
MTUS1
resolver
genesymbol_syn
ATBP
resolver
genesymbol_syn
ATIP
resolver
genesymbol_syn
GK1
resolver
genesymbol_syn
KIAA1288
resolver
genesymbol_syn
MTSG1
resolver
hgnc
HGNC:29789
resolver
uniprot
A8K135
resolver
uniprot
B2RBJ6
resolver
uniprot
B3KWJ9
resolver
uniprot
B4DH03
resolver
uniprot
B9EGA1
resolver
uniprot
D3DSP8
resolver
uniprot
Q63HJ6
resolver
uniprot
Q659F4
resolver
uniprot
Q6PK49
resolver
uniprot
Q6URW7
resolver
uniprot
Q8N4M6
resolver
uniprot
Q8WTT9
resolver
uniprot
Q9H7T2
resolver
uniprot_entry
MTUS1_HUMAN
resolver
uniprot_sec
A8K135
resolver
uniprot_sec
B2RBJ6
resolver
uniprot_sec
B3KWJ9
resolver
uniprot_sec
B4DH03
resolver
uniprot_sec
B9EGA1
resolver
uniprot_sec
D3DSP8
resolver
uniprot_sec
Q63HJ6
resolver
uniprot_sec
Q659F4
resolver
uniprot_sec
Q6PK49
resolver
uniprot_sec
Q6URW7
resolver
uniprot_sec
Q8N4M6
resolver
uniprot_sec
Q8WTT9
resolver
uniprot_sec
Q9H7T2
resolver
amino_acid_sequence
MTDDNSDDKIEDELQTFFTSDKDGNTHAYNPKSPPTQNSSASSVNWNSANPDDMVVDYETDPAVVTGENISLSLQGVEVFGHEKSSSDFISKQVLDMHKDSICQCPALVGTEKPKYLQHSCHSLEAVEGQSVEPSLPFVWKPNDNLNCAGYCDALELNQTFDMTVDKVNCTFISHHAIGKSQSFHTAGSLPPTGRRSGSTSSLSYSTWTSSHSDKTHARETTYDRESFENPQVTPSEAQDMTYTAFSDVVMQSEVFVSDIGNQCACSSGKVTSEYTDGSQQRLVGEKETQALTPVSDGMEVPNDSALQEFFCLSHDESNSEPHSQSSYRHKEMGQNLRETVSYCLIDDECPLMVPAFDKSEAQVLNPEHKVTETEDTQMVSKGKDLGTQNHTSELILSSPPGQKVGSSFGLTWDANDMVISTDKTMCMSTPVLEPTKVTFSVSPIEATEKCKKVEKGNRGLKNIPDSKEAPVNLCKPSLGKSTIKTNTPIGCKVRKTEIISYPRPNFKNVKAKVMSRAVLQPKDAALSKVTPRPQQTSASSPSSVNSRQQTVLSRTPRSDLNADKKAEILINKTHKQQFNKLITSQAVHVTTHSKNASHRVPRTTSAVKSNQEDVDKASSSNSACETGSVSALFQKIKGILPVKMESAECLEMTYVPNIDRISPEKKGEKENGTSMEKQELKQEIMNETFEYGSLFLGSASKTTTTSGRNISKPDSCGLRQIAAPKAKVGPPVSCLRRNSDNRNPSADRAVSPQRIRRVSSSGKPTSLKTAQSSWVNLPRPLPKSKASLKSPALRRTGSTPSIASTHSELSTYSNNSGNAAVIKYEEKPPKPAFQNGSSGSFYLKPLVSRAHVHLMKTPPKGPSRKNLFTALNAVEKSRQKNPRSLCIQPQTAPDALPPEKTLELTQYKTKCENQSGFILQLKQLLACGNTKFEALTVVIQHLLSEREEALKQHKTLSQELVNLRGELVTASTTCEKLEKARNELQTVYEAFVQQHQAEKTERENRLKEFYTREYEKLRDTYIEEAEKYKMQLQEQFDNLNAAHETSKLEIEASHSEKLELLKKAYEASLSEIKKGHEIEKKSLEDLLSEKQESLEKQINDLKSENDALNEKLKSEEQKRRAREKANLKNPQIMYLEQELESLKAVLEIKNEKLHQQDIKLMKMEKLVDNNTALVDKLKRFQQENEELKARMDKHMAISRQLSTEQAVLQESLEKESKVNKRLSMENEELLWKLHNGDLCSPKRSPTSSAIPLQSPRNSGSFPSPSISPR
uniprot
proteins
disease_involvement
DISEASE: Hepatocellular carcinoma (HCC) [MIM:114550]: A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes. {ECO:0000269|PubMed:16650523}. Note=The gene represented in this entry may be involved in disease pathogenesis.
uniprot
proteins
function
FUNCTION: Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Isoform 1 inhibits breast cancer cell proliferation, delays the progression of mitosis by prolonging metaphase and reduces tumor growth. {ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}.
uniprot
proteins
mass_dalton
141397
uniprot
proteins
protein_family
MTUS1 family
uniprot
proteins
pubmed
10574462
uniprot
proteins
pubmed
10697957
uniprot
proteins
pubmed
12692079
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15123706
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16270321
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
16650523
uniprot
proteins
pubmed
16887298
uniprot
proteins
pubmed
16969489
uniprot
proteins
pubmed
17656251
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19794912
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
1270
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:10697957, ECO:0000269|PubMed:12692079, ECO:0000269|PubMed:19794912}. Golgi apparatus {ECO:0000250}. Cell membrane {ECO:0000250}. Nucleus {ECO:0000250}. Note=In neurons, translocates into the nucleus after treatment with angiotensin-II. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Localizes with the mitotic spindle during mitosis and with the intercellular bridge during cytokinesis.
uniprot
proteins