Gemin8
entrez
237221
canonical
uniprot
Q8BHE1
canonical
ensembl
ENSMUSG00000040621
resolver
ensp
ENSMUSP00000084414
resolver
ensp
ENSMUSP00000085137
resolver
ensp
ENSMUSP00000093971
resolver
ensp
ENSMUSP00000118482
resolver
enst
ENSMUST00000056410
resolver
enst
ENSMUST00000087169
resolver
enst
ENSMUST00000096252
resolver
enst
ENSMUST00000130880
resolver
genesymbol
Gemin8
resolver
genesymbol_syn
Fam51a1
resolver
uniprot
B1AVP4
resolver
uniprot
B1AVP5
resolver
uniprot
Q3TUT1
resolver
uniprot
Q8R3W9
resolver
uniprot_entry
B1AVP5_MOUSE
resolver
uniprot_entry
GEMI8_MOUSE
resolver
uniprot_sec
B1AVP4
resolver
uniprot_sec
Q3TUT1
resolver
uniprot_sec
Q8R3W9
resolver
amino_acid_sequence
MASNWRASASWYSHPVYARYWQHYHHAMLWMQGHQNAYRKFRDSYFTSPWLFPHGALPWNSPAYEAGHPWDSQGQHMAQQESPYRVSHPKSPGQPLRNSSRTQASTRGNEARCEEEELESDSDDEVECDLSNMEITEELRQYFAQTERHREERRRQQQLDAERLNDYVNADHGLYFNHRRSLEPPSEKPWERRQAEMKRLYGNSAPKILAMETAVQLSFDKHCDRKQPKYWPVIPLKF
uniprot
proteins
function
FUNCTION: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (By similarity). {ECO:0000250|UniProtKB:Q9NWZ8}.
uniprot
proteins
mass_dalton
28396
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16434402
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
238
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, gem {ECO:0000250|UniProtKB:Q9NWZ8}. Cytoplasm {ECO:0000250|UniProtKB:Q9NWZ8}. Note=Found in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm (By similarity). {ECO:0000250}.
uniprot
proteins