Pf4
entrez
360918
canonical
uniprot
P06765
canonical
ensembl
ENSRNOG00000028015
resolver
ensembl
ENSRNOG00065017253
resolver
ensp
ENSRNOP00000032276
resolver
ensp
ENSRNOP00065022760
resolver
enst
ENSRNOT00000033406
resolver
enst
ENSRNOT00065028749
resolver
genesymbol
Pf4
resolver
genesymbol_syn
Cxcl4
resolver
genesymbol_syn
Scyb4
resolver
uniprot_entry
PLF4_RAT
resolver
amino_acid_sequence
MSAAAVFRGLRPSPELLLLGLLLLPAVVAVTRASPEESDGDLSCVCVKTSSSRIHLKRITSLEVIKAGPHCAVPQLIATLKNGSKICLDRQVPLYKKIIKKLLES
uniprot
proteins
function
FUNCTION: Chemokine released during platelet aggregation that plays a role in different biological processes including hematopoiesis, cell proliferation, differentiation, and activation. Acts via different functional receptors including CCR1, CXCR3A or CXCR3B. Upon interaction with CXCR3A receptor, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling. Neutralizes the anticoagulant effect of heparin by binding more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Plays a role in the inhibition of hematopoiesis and in the maintenance of hematopoietic stem cell (HSC) quiescence. Chemotactic for neutrophils and monocytes via CCR1. Inhibits endothelial cell proliferation. In cooperation with toll-like receptor 8/TLR8, induces chromatin remodeling and activates inflammatory gene expression via the TBK1-IRF5 axis. In addition, induces myofibroblast differentiation and collagen synthesis in different precursor cells, including endothelial cells, by stimulating endothelial-to-mesenchymal transition. Interacts with thrombomodulin/THBD to enhance the activation of protein C and thus potentiates its anticoagulant activity. {ECO:0000250|UniProtKB:P02776}.
uniprot
proteins
mass_dalton
11287
uniprot
proteins
post_translational_modification
PTM: O-linked glycan consists of Gal-GalNAc disaccharide which is modified with sialic acid residues (microheterogeneity). {ECO:0000269|PubMed:8033893}.
uniprot
proteins
protein_family
Intercrine alpha (chemokine CxC) family
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
3821732
uniprot
proteins
pubmed
8033893
uniprot
proteins
sequence_length
105
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins