Pdia6
entrez
286906
canonical
uniprot
Q63081
canonical
ensembl
ENSRNOG00000050197
resolver
ensp
ENSRNOP00000079392
resolver
enst
ENSRNOT00000114398
resolver
genesymbol
Pdia6
resolver
genesymbol_syn
Cabp1
resolver
genesymbol_syn
Txndc7
resolver
uniprot
A0A8I6G592
resolver
uniprot
Q641Y3
resolver
uniprot_entry
A0A8I6G592_RAT
resolver
uniprot_entry
PDIA6_RAT
resolver
uniprot_sec
Q641Y3
resolver
amino_acid_sequence
MARLVLGLVSCTFFLAVSALYSSSDDVIELTPSNFNREVIQSDSLWLVEFYAPWCGHCQRLTPEWKKAASALKDVVKVGAVNADKHQSLGGQYGVQGFPTIKIFGANKNKPEDYQGGRTGEAIVDAALSALRQLVKDRLGGRSGGYSSGKQGRGDSSSKKDVVELTDDTFDKNVLDSEDVWMVEFYAPWCGHCKNLEPEWAAAATEVKEQTKGKVKLAAVDATVNQVLASRYGIKGFPTIKIFQKGESPVDYDGGRTRSDIVSRALDLFSDNAPPPELLEIINEDIAKKTCEEHQLCVVAVLPHILDTGATGRNSYLEVLLKLADKYKKKMWGWLWTEAGAQYELENALGIGGFGYPAMAAINARKMKFALLKGSFSEQGINEFLRELSFGRGSTAPVGGGSFPNITPREPWDGKDGELPVEDDIDLSDVELDDLEKDEL
uniprot
proteins
ec_number
5.3.4.1
uniprot
proteins
function
FUNCTION: May function as a chaperone that inhibits aggregation of misfolded proteins. Negatively regulates the unfolded protein response (UPR) through binding to UPR sensors such as ERN1, which in turn inactivates ERN1 signaling. May also regulate the UPR via the EIF2AK3 UPR sensor. Plays a role in platelet aggregation and activation by agonists such as convulxin, collagen and thrombin. {ECO:0000250|UniProtKB:Q15084}.
uniprot
proteins
mass_dalton
48173
uniprot
proteins
protein_family
Protein disulfide isomerase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7876340
uniprot
proteins
sequence_length
440
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:Q15084}. Cell membrane {ECO:0000250|UniProtKB:Q15084}. Melanosome {ECO:0000250|UniProtKB:Q15084}.
uniprot
proteins