Dusp4
entrez
60587
canonical
uniprot
Q62767
canonical
ensembl
ENSRNOG00000011921
resolver
ensp
ENSRNOP00000016328
resolver
enst
ENSRNOT00000016328
resolver
genesymbol
Dusp4
resolver
genesymbol_syn
Mkp2
resolver
uniprot
G3V7L2
resolver
uniprot_entry
DUS4_RAT
resolver
uniprot_entry
G3V7L2_RAT
resolver
amino_acid_sequence
MVTMEELREMDCSVLKRLMNRDENGGTAGSSGGSHGALGLLSGGKCLLLDCRPFLAHSAGYIRGSVNVRCNTIVRRRAKGSVSLEQILPAEEEVRARLRSGLYSAVIVYDERSPRAESLREDSTVSLVVQALRRNAERTDICLLKGGYERFSSEYPEFCSKTKALAAIPPPVPPSTNESLDLGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLTTSCAAEAASPSGPLRERGKATPTPTSQFVFSFPVSVGVHAAPSNLPYLHSPITTSPSC
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. {ECO:0000269|PubMed:7782322}.
uniprot
proteins
mass_dalton
43187
uniprot
proteins
post_translational_modification
PTM: Phosphorylation in the C-terminus by ERK1/2 inhibits proteasomal degradation and stabilizes the protein. {ECO:0000250|UniProtKB:Q13115}.
uniprot
proteins
protein_family
Non-receptor class dual specificity subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
7782322
uniprot
proteins
sequence_length
395
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13115}.
uniprot
proteins