Tnfrsf11a
entrez
21934
canonical
uniprot
O35305
canonical
ensembl
ENSMUSG00000026321
resolver
ensp
ENSMUSP00000027559
resolver
enst
ENSMUST00000027559
resolver
genesymbol
Tnfrsf11a
resolver
genesymbol_syn
Rank
resolver
uniprot
Q8VCT7
resolver
uniprot_entry
TNR11_MOUSE
resolver
uniprot_sec
Q8VCT7
resolver
amino_acid_sequence
MAPRARRRRQLPAPLLALCVLLVPLQVTLQVTPPCTQERHYEHLGRCCSRCEPGKYLSSKCTPTSDSVCLPCGPDEYLDTWNEEDKCLLHKVCDAGKALVAVDPGNHTAPRRCACTAGYHWNSDCECCRRNTECAPGFGAQHPLQLNKDTVCTPCLLGFFSDVFSSTDKCKPWTNCTLLGKLEAHQGTTESDVVCSSSMTLRRPPKEAQAYLPSLIVLLLFISVVVVAAIIFGVYYRKGGKALTANLWNWVNDACSSLSGNKESSGDRCAGSHSATSSQQEVCEGILLMTREEKMVPEDGAGVCGPVCAAGGPWAEVRDSRTFTLVSEVETQGDLSRKIPTEDEYTDRPSQPSTGSLLLIQQGSKSIPPFQEPLEVGENDSLSQCFTGTESTVDSEGCDFTEPPSRTDSMPVSPEKHLTKEIEGDSCLPWVVSSNSTDGYTGSGNTPGEDHEPFPGSLKCGPLPQCAYSMGFPSEAAASMAEAGVRPQDRADERGASGSGSSPSDQPPASGNVTGNSNSTFISSGQVMNFKGDIIVVYVSQTSQEGPGSAEPESEPVGRPVQEETLAHRDSFAGTAPRFPDVCATGAGLQEQGAPRQKDGTSRPVQEQGGAQTSLHTQGSGQCAE
uniprot
proteins
function
FUNCTION: Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis (PubMed:20483727, PubMed:23478294, PubMed:9878548). Its interaction with EEIG1 promotes osteoclastogenesis via facilitating the transcription of NFATC1 and activation of PLCG2 (PubMed:23478294). Involved in the regulation of interactions between T-cells and dendritic cells (PubMed:9367155). {ECO:0000269|PubMed:20483727, ECO:0000269|PubMed:23478294, ECO:0000269|PubMed:9367155, ECO:0000269|PubMed:9878548}.
uniprot
proteins
mass_dalton
66621
uniprot
proteins
mutagenesis
MUTAGEN 532..534; /note="GDI->AAA: Some decrease in interaction with STAC2."; /evidence="ECO:0000269|PubMed:29348675"; MUTAGEN 535..537; /note="IVV->AAA: Almost complete loss of interaction with STAC2."; /evidence="ECO:0000269|PubMed:29348675"; MUTAGEN 538..540; /note="YVS->AAA: Almost complete loss of interaction with STAC2."; /evidence="ECO:0000269|PubMed:29348675"; MUTAGEN 541..543; /note="QTS->AAA: No effect on interaction with STAC2."; /evidence="ECO:0000269|PubMed:29348675
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20483727
uniprot
proteins
pubmed
23039992
uniprot
proteins
pubmed
23478294
uniprot
proteins
pubmed
29348675
uniprot
proteins
pubmed
9367155
uniprot
proteins
pubmed
9878548
uniprot
proteins
sequence_length
625
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9Y6Q6}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:23478294, ECO:0000269|PubMed:29348675}. Note=Following TNFSF11/RANKL stimulation, recruited to lipid rafts along with STAC2. {ECO:0000269|PubMed:29348675}.
uniprot
proteins
transmembrane_region
TRANSMEM 215..234; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins