Myoc
entrez
81523
canonical
uniprot
Q9R1J4
canonical
ensembl
ENSRNOG00000003221
resolver
ensp
ENSRNOP00000004386
resolver
enst
ENSRNOT00000004386
resolver
genesymbol
Myoc
resolver
genesymbol_syn
Tigr
resolver
uniprot
G3V6E8
resolver
uniprot
Q9Z2Y4
resolver
uniprot_entry
G3V6E8_RAT
resolver
uniprot_entry
MYOC_RAT
resolver
uniprot_sec
Q9Z2Y4
resolver
amino_acid_sequence
MPSCAYCCSCGPKMPALQLLFLACLVWGMGARTAQFRKANDRSGRCQYTFTVASPSESSCPREDQAMSAIQDLQRDSSIQHADLESTKARVRSLESLLHQMTSGGVTGTQEVQEGLQGQLGALRRERDQLETQTRDLEVAYNNLLRDKSALEEEKRQLEQENKDLARRLEGSSQEVARLRRGQCPSTHHPSQDMLPGSREVSQWNLDTLAFQELKSELTEVPASQILKNQSGHPRSKEGDKGCGVLMWVGEPVTLRTAETITGKYGVWMRDPKPTHPYTQETTWRIDTVGTGIRQVFEYSQISQFEQGYPSKVHVLPQALESTGAVVYSGSLYFQGAESRTVLRYELNTETVKAEKEIPGAGYHGQFPYAWGGYTDIDLAVDESGLWVIYSTEETRGAIVLSKLNPENLELESTWETNIRKQSVANAFVICGILYTVSSYSSVHATINFAYDTNTGISKTLTIPFKNRYKYSSMVDYNPLERKLFAWDNFNMVTYDIKLSEM
uniprot
proteins
function
FUNCTION: Secreted glycoprotein regulating the activation of different signaling pathways in adjacent cells to control different processes including cell adhesion, cell-matrix adhesion, cytoskeleton organization and cell migration. Promotes substrate adhesion, spreading and formation of focal contacts. Negatively regulates cell-matrix adhesion and stress fiber assembly through Rho protein signal transduction. Modulates the organization of actin cytoskeleton by stimulating the formation of stress fibers through interactions with components of Wnt signaling pathways. Promotes cell migration through activation of PTK2 and the downstream phosphatidylinositol 3-kinase signaling. Plays a role in bone formation and promotes osteoblast differentiation in a dose-dependent manner through mitogen-activated protein kinase signaling. Mediates myelination in the peripheral nervous system through ERBB2/ERBB3 signaling. Plays a role as a regulator of muscle hypertrophy through the components of dystrophin-associated protein complex. Involved in positive regulation of mitochondrial depolarization. Plays a role in neurite outgrowth. May participate in the obstruction of fluid outflow in the trabecular meshwork. {ECO:0000250|UniProtKB:O70624, ECO:0000250|UniProtKB:Q99972}.
uniprot
proteins
mass_dalton
56442
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. {ECO:0000250|UniProtKB:Q2PT31}.; PTM: Undergoes a calcium-dependent proteolytic cleavage at Gln-225 by CAPN2 in the endoplasmic reticulum. The result is the production of two fragments, one of 35 kDa containing the C-terminal olfactomedin-like domain, and another of 20 kDa containing the N-terminal leucine zipper-like domain (By similarity). {ECO:0000250}.; PTM: Glycosylated. {ECO:0000250|UniProtKB:Q99972}.
uniprot
proteins
pubmed
10833334
uniprot
proteins
pubmed
23629661
uniprot
proteins
sequence_length
502
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q99972}. Golgi apparatus {ECO:0000250|UniProtKB:Q99972}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q99972}. Secreted, extracellular space {ECO:0000250|UniProtKB:Q99972}. Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q99972}. Secreted, extracellular exosome {ECO:0000250|UniProtKB:Q99972}. Mitochondrion {ECO:0000250|UniProtKB:Q99972}. Mitochondrion intermembrane space {ECO:0000250|UniProtKB:Q99972}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q99972}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q99972}. Rough endoplasmic reticulum {ECO:0000250|UniProtKB:Q99972}. Cell projection {ECO:0000250|UniProtKB:Q99972}. Cell projection, cilium {ECO:0000250|UniProtKB:Q99972}. Note=Located preferentially in the ciliary rootlet and basal body of the connecting cilium of photoreceptor cells, and in the rough endoplasmic reticulum. It is only imported to mitochondria in the trabecular meshwork. Localizes to the Golgi apparatus in Schlemm's canal endothelial cells. Appears in the extracellular space of trabecular meshwork cells by an unconventional mechanism, likely associated with exosome-like vesicles. Localizes in trabecular meshwork extracellular matrix. {ECO:0000250|UniProtKB:Q99972}.; SUBCELLULAR LOCATION: [Myocilin, C-terminal fragment]: Secreted {ECO:0000250}.; SUBCELLULAR LOCATION: [Myocilin, N-terminal fragment]: Endoplasmic reticulum. Note=Remains retained in the endoplasmic reticulum. {ECO:0000250}.
uniprot
proteins