P24388
uniprot
P24388
canonical
amino_acid_sequence
MSPNFKLQCHFTLILLTALRGESRYLEVQEAAVYDPFLLFSANLKRNLAEEQPYRRALRCLDMLSLPGQFTFTADQPQLHCAAFFIGEPEEFITIHFDLVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPTRERYTDFCESGLTRRSVTSSQNVAMVFFRVHEPGNGFTITIKTDPNLFPCNIISQTPSGRFALVVPYQHQNCSFSIIYPVTIKISDLALGHLHGLQLKKPAAGCGGTGDFVELLGGTGLDTSKMMLLVDLCYPFHGPAQMKISCDNAVVRMVSSGKHMNRVTFEYRQLEPLELETSTRNSIPEYCLSSL
uniprot
proteins
function
FUNCTION: Specifically binds and inactivates the corticotropin-releasing hormone (CRH) and urocortin-1 (UCN) hormones, thereby inhibiting the hypothalamus-pituitary-adrenal axis and preventing corticotropin hormone (ACTH) production (PubMed:1846945). May be required to prevent inappropriate pituitary-adrenal stimulation in pregnancy (By similarity). {ECO:0000250|UniProtKB:P24387, ECO:0000269|PubMed:1846945}.
uniprot
proteins
mass_dalton
36121
uniprot
proteins
protein_family
CRF-binding protein family
uniprot
proteins
pubmed
1846945
uniprot
proteins
sequence_length
322
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P24387}.
uniprot
proteins