Syne4
entrez
292781
canonical
uniprot
Q5M844
canonical
genesymbol
Syne4
resolver
uniprot_entry
SYNE4_RAT
resolver
amino_acid_sequence
MAQFPLLGHGFPPEPVNHPLGGPRGLDVAGPTICPAPEEEPSRPEQVQASLDAPEHFMDEPKSTESATSPSKLPLASSHEHQDGGKPCEALQAELQGAAERVDALLVFGEGLAERSEPRAWTSLEQVLRALGTHRDTIFQRLWQLQAQLISYSLVLEKANLLDQDLEVEGDSDGPAAGGVWGPWAPSIFPTPAELEWDPAGDVGGLGPSGQKISRIPGAPCELCGYRGSQSSGQGFEDLLSLGLGHRKHLAAHHRRRLQKPQDKKRQGPPSLPDAMLEVDRGVPAPASRRPLTFLLLLLFLLLVGATLLLPLSGVPCCSHTRLARTPYLVLSYVNGLPPI
uniprot
proteins
function
FUNCTION: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology, by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
36515
uniprot
proteins
protein_family
Nesprin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
340
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus outer membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Note=Localization at the nucleus outer membrane location requires the presence of SUN1. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 292..312; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00385
uniprot
proteins