KIR2DL4
entrez
3805
canonical
uniprot
Q99706
canonical
ensembl
ENSG00000189013
resolver
ensembl
ENSG00000273575
resolver
ensembl
ENSG00000274232
resolver
ensembl
ENSG00000274609
resolver
ensembl
ENSG00000274955
resolver
ensembl
ENSG00000275237
resolver
ensembl
ENSG00000275317
resolver
ensembl
ENSG00000275456
resolver
ensembl
ENSG00000275699
resolver
ensembl
ENSG00000276044
resolver
ensembl
ENSG00000276779
resolver
ensembl
ENSG00000277362
resolver
ensembl
ENSG00000277750
resolver
ensembl
ENSG00000277964
resolver
ensembl
ENSG00000278074
resolver
ensembl
ENSG00000278271
resolver
ensembl
ENSG00000278430
resolver
ensembl
ENSG00000283869
resolver
ensembl
ENSG00000283961
resolver
ensembl
ENSG00000284013
resolver
ensembl
ENSG00000284365
resolver
ensembl
ENSG00000284460
resolver
ensembl
ENSG00000284509
resolver
ensp
ENSP00000339634
resolver
ensp
ENSP00000351988
resolver
ensp
ENSP00000477601
resolver
ensp
ENSP00000477886
resolver
ensp
ENSP00000477887
resolver
ensp
ENSP00000478362
resolver
ensp
ENSP00000478491
resolver
ensp
ENSP00000479014
resolver
ensp
ENSP00000479179
resolver
ensp
ENSP00000479993
resolver
ensp
ENSP00000480801
resolver
ensp
ENSP00000482206
resolver
ensp
ENSP00000482383
resolver
ensp
ENSP00000482452
resolver
ensp
ENSP00000483101
resolver
ensp
ENSP00000483782
resolver
ensp
ENSP00000484019
resolver
ensp
ENSP00000484307
resolver
ensp
ENSP00000484336
resolver
ensp
ENSP00000484389
resolver
ensp
ENSP00000491003
resolver
ensp
ENSP00000491604
resolver
ensp
ENSP00000491832
resolver
enst
ENST00000359085
resolver
enst
ENST00000612573
resolver
enst
ENST00000612660
resolver
enst
ENST00000613053
resolver
enst
ENST00000614653
resolver
enst
ENST00000615970
resolver
enst
ENST00000616354
resolver
enst
ENST00000618297
resolver
enst
ENST00000618358
resolver
enst
ENST00000618567
resolver
enst
ENST00000618607
resolver
enst
ENST00000619637
resolver
enst
ENST00000619848
resolver
enst
ENST00000620484
resolver
enst
ENST00000620486
resolver
enst
ENST00000621002
resolver
enst
ENST00000621484
resolver
enst
ENST00000622348
resolver
enst
ENST00000622437
resolver
enst
ENST00000639468
resolver
enst
ENST00000639624
resolver
enst
ENST00000640895
resolver
genesymbol
KIR2DL4
resolver
genesymbol_syn
CD158D
resolver
genesymbol_syn
KIR103AS
resolver
hgnc
HGNC:6332
resolver
uniprot
A0A0B4J1S6
resolver
uniprot
A0A1W2PQ98
resolver
uniprot
A0A376A929
resolver
uniprot
A8W795
resolver
uniprot
O14621
resolver
uniprot
O14622
resolver
uniprot
O14623
resolver
uniprot
O14624
resolver
uniprot
O43534
resolver
uniprot
P78400
resolver
uniprot
P78401
resolver
uniprot
Q8N738
resolver
uniprot
Q99559
resolver
uniprot
Q99560
resolver
uniprot
Q99561
resolver
uniprot
Q99562
resolver
uniprot
Q9UQJ7
resolver
uniprot_entry
A0A0B4J1S6_HUMAN
resolver
uniprot_entry
A0A376A929_HUMAN
resolver
uniprot_entry
KI2L4_HUMAN
resolver
uniprot_sec
A0A1W2PQ98
resolver
uniprot_sec
A8W795
resolver
uniprot_sec
O14621
resolver
uniprot_sec
O14622
resolver
uniprot_sec
O14623
resolver
uniprot_sec
O14624
resolver
uniprot_sec
O43534
resolver
uniprot_sec
P78400
resolver
uniprot_sec
P78401
resolver
uniprot_sec
Q8N738
resolver
uniprot_sec
Q99559
resolver
uniprot_sec
Q99560
resolver
uniprot_sec
Q99561
resolver
uniprot_sec
Q99562
resolver
uniprot_sec
Q9UQJ7
resolver
amino_acid_sequence
MSMSPTVIILACLGFFLDQSVWAHVGGQDKPFCSAWPSAVVPQGGHVTLRCHYRRGFNIFTLYKKDGVPVPELYNRIFWNSFLISPVTPAHAGTYRCRGFHPHSPTEWSAPSNPLVIMVTGLYEKPSLTARPGPTVRAGENVTLSCSSQSSFDIYHLSREGEAHELRLPAVPSINGTFQADFPLGPATHGETYRCFGSFHGSPYEWSDPSDPLPVSVTGNPSSSWPSPTEPSFKTGIARHLHAVIRYSVAIILFTILPFFLLHRWCSKKKDAAVMNQEPAGHRTVNREDSDEQDPQEVTYAQLDHCIFTQRKITGPSQRSKRPSTDTSVCIELPNAEPRALSPAHEHHSQALMGSSRETTALSQTQLASSNVPAAGI
uniprot
proteins
function
FUNCTION: Receptor for non-classical major histocompatibility class Ib HLA-G molecules. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M). In decidual NK cells, binds peptide-bound HLA-G-B2M complex and triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:16366734, PubMed:23184984, PubMed:29262349). May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells (PubMed:10190900, PubMed:16366734). Upon interaction with peptide-bound HLA-G-B2M, initiates signaling from the endosomal compartment leading to downstream activation of PRKDC-XRCC5 and AKT1, and ultimately triggering NF-kappa-B-dependent pro-inflammatory response (PubMed:20179272). {ECO:0000269|PubMed:10190900, ECO:0000269|PubMed:16366734, ECO:0000269|PubMed:20179272, ECO:0000269|PubMed:23184984, ECO:0000269|PubMed:29262349}.
uniprot
proteins
mass_dalton
41487
uniprot
proteins
mutagenesis
MUTAGEN 246..247; /note="RY->GT: Does not affect targeting to the endosomal compartment."; /evidence="ECO:0000269|PubMed:16366734
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
10190900
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
16366734
uniprot
proteins
pubmed
18082267
uniprot
proteins
pubmed
18604210
uniprot
proteins
pubmed
19304799
uniprot
proteins
pubmed
20179272
uniprot
proteins
pubmed
23184984
uniprot
proteins
pubmed
29262349
uniprot
proteins
pubmed
8946682
uniprot
proteins
pubmed
9059894
uniprot
proteins
pubmed
9234477
uniprot
proteins
pubmed
9430220
uniprot
proteins
sequence_length
377
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Early endosome membrane {ECO:0000269|PubMed:16366734}.
uniprot
proteins
transmembrane_region
TRANSMEM 243..263; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins