Pdcd6
entrez
18570
canonical
uniprot
P12815
canonical
ensembl
ENSMUSG00000021576
resolver
ensp
ENSMUSP00000022060
resolver
ensp
ENSMUSP00000152458
resolver
genesymbol
Pdcd6
resolver
genesymbol_syn
Alg2
resolver
uniprot
Q545I0
resolver
uniprot
Q61145
resolver
uniprot_entry
PDCD6_MOUSE
resolver
uniprot_sec
Q545I0
resolver
uniprot_sec
Q61145
resolver
amino_acid_sequence
MAAYSYRPGPGGGPGPAAGAALPDQSFLWNVFQRVDKDRSGVISDNELQQALSNGTWTPFNPVTVRSIISMFDRENKAGVNFSEFTGVWKYITDWQNVFRTYDRDNSGMIDKNELKQALSGFGYRLSDQFHDILIRKFDRQGRGQIAFDDFIQGCIVLQRLTDIFRRYDTDQDGWIQVSYEQYLSMVFSIV
uniprot
proteins
function
FUNCTION: Calcium sensor that plays a key role in processes such as endoplasmic reticulum (ER)-Golgi vesicular transport, endosomal biogenesis or membrane repair (PubMed:10744743, PubMed:11525164, PubMed:27541325). Acts as an adapter that bridges unrelated proteins or stabilizes weak protein-protein complexes in response to calcium: calcium-binding triggers exposure of apolar surface, promoting interaction with different sets of proteins thanks to 3 different hydrophobic pockets, leading to translocation to membranes (PubMed:10744743, PubMed:11525164, PubMed:27541325). Involved in ER-Golgi transport by promoting the association between PDCD6IP and TSG101, thereby bridging together the ESCRT-III and ESCRT-I complexes (PubMed:10744743, PubMed:11525164, PubMed:27541325). Together with PEF1, acts as a calcium-dependent adapter for the BCR(KLHL12) complex, a complex involved in ER-Golgi transport by regulating the size of COPII coats (By similarity). In response to cytosolic calcium increase, the heterodimer formed with PEF1 interacts with, and bridges together the BCR(KLHL12) complex and SEC31 (SEC31A or SEC31B), promoting monoubiquitination of SEC31 and subsequent collagen export, which is required for neural crest specification (By similarity). Involved in the regulation of the distribution and function of MCOLN1 in the endosomal pathway (By similarity). Promotes localization and polymerization of TFG at endoplasmic reticulum exit site (By similarity). Required for T-cell receptor-, Fas-, and glucocorticoid-induced apoptosis (PubMed:8560270). May mediate Ca(2+)-regulated signals along the death pathway: interaction with DAPK1 can accelerate apoptotic cell death by increasing caspase-3 activity (By similarity). Its role in apoptosis may however be indirect, as suggested by knockout experiments (PubMed:12024023). May inhibit KDR/VEGFR2-dependent angiogenesis; the function involves inhibition of VEGF-induced phosphorylation of the Akt signaling pathway (By similarity). {ECO:0000250|UniProtKB:O75340, ECO:0000269|PubMed:10744743, ECO:0000269|PubMed:11525164, ECO:0000269|PubMed:12024023, ECO:0000269|PubMed:27541325, ECO:0000305|PubMed:12024023}.; FUNCTION: [Isoform 2]: Has a lower Ca(2+) affinity than isoform 1 (PubMed:10744743). {ECO:0000269|PubMed:10744743}.
uniprot
proteins
mass_dalton
21867
uniprot
proteins
mutagenesis
MUTAGEN 169; /note="D->A: Abolishes magnesium and calcium-binding to the EF-hand 5 domain (EF5)."; /evidence="ECO:0000269|PubMed:27541325
uniprot
proteins
pubmed
10200558
uniprot
proteins
pubmed
10744743
uniprot
proteins
pubmed
11525164
uniprot
proteins
pubmed
12024023
uniprot
proteins
pubmed
12522145
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17889823
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2736249
uniprot
proteins
pubmed
27541325
uniprot
proteins
pubmed
8560270
uniprot
proteins
sequence_length
191
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O75340}; Peripheral membrane protein {ECO:0000250|UniProtKB:O75340}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250|UniProtKB:O75340}. Cytoplasm {ECO:0000250|UniProtKB:O75340}. Nucleus {ECO:0000250|UniProtKB:O75340}. Endosome {ECO:0000250|UniProtKB:O75340}. Note=Interaction with RBM22 induces relocalization from the cytoplasm to the nucleus. Translocated from the cytoplasm to the nucleus after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules. In response to calcium increase, relocates from cytoplasm to COPII vesicle coat. Localizes to endoplasmic reticulum exit site (ERES). {ECO:0000250|UniProtKB:O75340}.
uniprot
proteins