Slc11a1
entrez
316519
canonical
uniprot
P70553
canonical
ensembl
ENSRNOG00000014956
resolver
ensp
ENSRNOP00000054282
resolver
ensp
ENSRNOP00000071174
resolver
enst
ENSRNOT00000057472
resolver
enst
ENSRNOT00000088679
resolver
genesymbol
Slc11a1
resolver
genesymbol_syn
Bcg
resolver
genesymbol_syn
Nramp1
resolver
uniprot
A0A0G2JZT3
resolver
uniprot
F1LSN8
resolver
uniprot
Q496Z6
resolver
uniprot_entry
A0A0G2JZT3_RAT
resolver
uniprot_entry
F1LSN8_RAT
resolver
uniprot_entry
NRAM1_RAT
resolver
uniprot_sec
Q496Z6
resolver
amino_acid_sequence
MIRDKNPQRVNRPSYGSISSLPSPAPQPEPSRNTYLSEKIPIPSTEQGTFSLRKLWAFTGPGFLMSIAFLDPGNIESDLQAGAVAEFKLLWVLLWATVLGLLCQRLAARLGVVTGKDLGEICHLYYPKVPRILLWLTIELAIVGSDMQEVIGTAISFNLLSAGRIPLWGGVLITIVDTFFFLFLDNYGLRKLEAFFGFLITIMALTFGYEYVVARPSQGALLKGLFLPSCPGCGQPELLQAVGIVGAIIMPHNIYLHSALVKSREVDRTRRGDVREANMYFLTEATIALFVSFIINLFVMAVFGQAFYQQTNEEAFNICANSSLHNYAKIFPRDNNTVSVDIYQGGVILGCLFGPAALYIWAVGLLAAGQSSTMTGTYAGQFVMEGFLKLRWSRFARVLLTRSCAILPTVLVAVFRDLRDLSGLNDLLNVLQSLLLPFAVLPILTFTSMPAVMQEFANGWLSKVITSCIMALVCAINLYFVISYLPSLPHPAYFGLVALLAIGYLGLTAYLAWTCCIAHGAKFLTHSSHQRFLYGLPIEEQEGREGSG
uniprot
proteins
function
FUNCTION: Antiporter that transports metal ions against a proton gradient, and which promotes host resistance to infection against intracellular parasites, such as M.bovis, S.typhimurium and L.donovani. Plays a key role in pathogen resistance in macrophages by mediating the export of metal ions from the phagosomal compartment, thereby limiting the nutrients available to intracellular pathogens and restricting their growth. Also promotes antimicrobial activity in neutrophils against pathogens that survive within phagocytic cells. {ECO:0000250|UniProtKB:P41251}.
uniprot
proteins
mass_dalton
60322
uniprot
proteins
protein_family
NRAMP (TC 2.A.55) family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8875897
uniprot
proteins
sequence_length
548
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:P41251}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000250|UniProtKB:P41251}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:P41251}; Multi-pass membrane protein {ECO:0000255}. Note=After onfection, vesicles migrate to the site of bacterial phagosomes. {ECO:0000250|UniProtKB:P41251}.
uniprot
proteins
transmembrane_region
TRANSMEM 58..77; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P49279"; TRANSMEM 90..107; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P49279"; TRANSMEM 129..156; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P49279"; TRANSMEM 167..184; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P49279"; TRANSMEM 188..208; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P49279"; TRANSMEM 238..257; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P49279"; TRANSMEM 281..299; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P49279"; TRANSMEM 359..380; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P49279"; TRANSMEM 394..413; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:P49279"; TRANSMEM 424..444; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:P49279"; TRANSMEM 459..480; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:P49279"; TRANSMEM 494..516; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:P49279
uniprot
proteins