Emg1
entrez
14791
canonical
uniprot
O35130
canonical
ensembl
ENSMUSG00000004268
resolver
ensp
ENSMUSP00000004379
resolver
ensp
ENSMUSP00000292154
resolver
ensp
ENSMUSP00000342212
resolver
enst
ENSMUST00000004379
resolver
genesymbol
Emg1
resolver
genesymbol_syn
C2f
resolver
genesymbol_syn
Grcc2f
resolver
uniprot
Q542P8
resolver
uniprot_entry
NEP1_MOUSE
resolver
uniprot_entry
Q542P8_MOUSE
resolver
amino_acid_sequence
MSAASGGFQPRERRFSVQEQDWETTPPKKLRLGAGSKCGGRRLIVVLEGASLETVKVGKTYELLNCDRHKSMLLKNGRDPGEVRPDITHQSLLMLMDSPLNRAGLLQVYIHTQKNVLIEVNPQTRIPRTFDRFCGLMVQLLHKLSVRAADGPQKLLKVIKNPVSDHFPVGCMKIGTSFSVEDISDIRELVPSSDPVVFVVGAFAHGKVSVEYTEKMVSISNYPLSAALTCAKVTTAFEEVWGVI
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position (By similarity). Also has an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes (By similarity). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). {ECO:0000250|UniProtKB:Q06287, ECO:0000250|UniProtKB:Q92979}.
uniprot
proteins
mass_dalton
26974
uniprot
proteins
protein_family
Class IV-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
RNA methyltransferase NEP1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9445485
uniprot
proteins
sequence_length
244
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q92979}. Note=Nuclear import can be mediated by the KPNB1/IMP7 importin heterodimer. {ECO:0000250|UniProtKB:Q92979}.
uniprot
proteins