BIRC3
entrez
330
canonical
uniprot
Q13489
canonical
ensembl
ENSG00000023445
resolver
ensp
ENSP00000263464
resolver
ensp
ENSP00000432907
resolver
ensp
ENSP00000501119
resolver
enst
ENST00000263464
resolver
enst
ENST00000526421
resolver
enst
ENST00000532808
resolver
genesymbol
BIRC3
resolver
genesymbol_syn
API2
resolver
genesymbol_syn
MIHC
resolver
genesymbol_syn
RNF49
resolver
hgnc
HGNC:591
resolver
uniprot
Q16628
resolver
uniprot
Q9HC27
resolver
uniprot
Q9UP46
resolver
uniprot_entry
BIRC3_HUMAN
resolver
uniprot_sec
Q16628
resolver
uniprot_sec
Q9HC27
resolver
uniprot_sec
Q9UP46
resolver
activity_regulation
ACTIVITY REGULATION: USP19 regulates the stability of BIRC3/c-IAP2 by preventing its ubiquitination. {ECO:0000269|PubMed:21849505}.
uniprot
proteins
amino_acid_sequence
MNIVENSIFLSNLMKSANTFELKYDLSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKRGDSPTEKHKKLYPSCRFVQSLNSVNNLEATSQPTFPSSVTNSTHSLLPGTENSGYFRGSYSNSPSNPVNSRANQDFSALMRSSYHCAMNNENARLLTFQTWPLTFLSPTDLAKAGFYYIGPGDRVACFACGGKLSNWEPKDNAMSEHLRHFPKCPFIENQLQDTSRYTVSNLSMQTHAARFKTFFNWPSSVLVNPEQLASAGFYYVGNSDDVKCFCCDGGLRCWESGDDPWVQHAKWFPRCEYLIRIKGQEFIRQVQASYPHLLEQLLSTSDSPGDENAESSIIHFEPGEDHSEDAIMMNTPVINAAVEMGFSRSLVKQTVQRKILATGENYRLVNDLVLDLLNAEDEIREEERERATEEKESNDLLLIRKNRMALFQHLTCVIPILDSLLTAGIINEQEHDVIKQKTQTSLQARELIDTILVKGNIAATVFRNSLQEAEAVLYEHLFVQQDIKYIPTEDVSDLPVEEQLRRLQEERTCKVCMDKEVSIVFIPCGHLVVCKDCAPSLRKCPICRSTIKGTVRTFLS
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving BIRC3 is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Translocation t(11;18)(q21;q21) with MALT1. This translocation is found in approximately 50% of cytogenetically abnormal low-grade MALT lymphoma.
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, IKBKE, TRAF1, and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. {ECO:0000269|PubMed:21931591, ECO:0000269|PubMed:23453969}.
uniprot
proteins
mass_dalton
68372
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated and degraded by the proteasome in apoptotic cells.
uniprot
proteins
protein_family
IAP family
uniprot
proteins
pubmed
10233894
uniprot
proteins
pubmed
11066071
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15665297
uniprot
proteins
pubmed
18414036
uniprot
proteins
pubmed
20651737
uniprot
proteins
pubmed
20888210
uniprot
proteins
pubmed
21447281
uniprot
proteins
pubmed
21849505
uniprot
proteins
pubmed
21931591
uniprot
proteins
pubmed
22095281
uniprot
proteins
pubmed
23453969
uniprot
proteins
pubmed
8548810
uniprot
proteins
pubmed
8552191
uniprot
proteins
pubmed
8643514
uniprot
proteins
sequence_length
604
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15665297}. Nucleus {ECO:0000269|PubMed:15665297}.
uniprot
proteins