Fbxo3
entrez
690634
canonical
uniprot
D4ABP9
canonical
ensembl
ENSRNOG00000009549
resolver
ensembl
ENSRNOG00055023734
resolver
ensembl
ENSRNOG00060001915
resolver
ensembl
ENSRNOG00065016205
resolver
ensp
ENSRNOP00000014478
resolver
ensp
ENSRNOP00055033113
resolver
ensp
ENSRNOP00060001957
resolver
ensp
ENSRNOP00065021218
resolver
enst
ENSRNOT00000014478
resolver
enst
ENSRNOT00055040768
resolver
enst
ENSRNOT00060002969
resolver
enst
ENSRNOT00065026991
resolver
genesymbol
Fbxo3
resolver
genesymbol_syn
Fbx3
resolver
uniprot_entry
FBX3_RAT
resolver
amino_acid_sequence
MAAVEAETGLLTLESLPTDPLLLILSFVDYRDLINCCYVSRRLSQLSTHDPLWRRHCKKYWLITEEEKARKNQCWKSLFIATYSDVGRYINHYAAIKKAWDDLKKYLEPRCPRMVLSLKEGAREEDLDAVEAQIGCKLPDDYRCSYRIHNGQKLVVPGLLGSMALSNHYRSEDLLDVDTAAGGFQQRQGLKYCLPLTFCIHTGLSQYIAVEAAEGRNKNEVFYQCPDQMARNPAAIDMFIIGATFTDWFTSYVNNVVSGGFPIIRDQIFRYIHDPECVATTGDITVSVSTSFLPELSSVHPPHYFFTYRIRIEMSRDALPEKACQLDSRYWRITNAKGDVEEVQGPGVVGEFPIISPGRIYEYTSCTTFSTTSGYMEGYYTFHFLYFKDKVFNVAIPRFHMACPTFRVSIARLEMGPDEYEEMEEEAEEEEEEENDDSADMDESDESDEDENESDEGEGEERRRRVFDVPIRRRRCSRLF
uniprot
proteins
function
FUNCTION: Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, SCF(FBXO3), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. The SCF(FBXO3) also acts as a regulator of inflammation by mediating ubiquitination and degradation of FBXL2 in response to lipopolysaccharide (LPS) (By similarity). The SCF(FBXO3) complex specifically recognizes FBXL2 phosphorylated at 'Thr-404' and promotes its ubiquitination (By similarity). {ECO:0000250|UniProtKB:Q9DC63, ECO:0000250|UniProtKB:Q9UK99}.
uniprot
proteins
mass_dalton
55355
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9UK99}.
uniprot
proteins
sequence_length
480
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UK99}. Note=Colocalizes with PML at the peripheries of nuclear bodies. {ECO:0000250|UniProtKB:Q9UK99}.
uniprot
proteins