Q8CC35
uniprot
Q8CC35
canonical
amino_acid_sequence
MLGAHFPPPPLGASEGRAAPCTFQIPDGSYRCLALEAEESSSEDGLQGEVRLVDLEEEGTSQSRANHGTPPLSRAPAIIQPSSCHREARGGFQRSDRPSHDWDVVQARKVMTASGSSSPVPRVAQKPALGRSTSFTENDLKEAKARSQQIAAQLTTPPSSNSRGVQLFNRRRQRVNEFTLESRGQRSPKLNQEALQTGRPLSPIGHAPGPSVKPTSPSKPGSPKHPSPQSPSRGVAGHIMEGYSEEASLLRHLEKVASEEEEVPLVVYLKENAALLTANGLHLSQSRETQQSSPNPPDTEVPSPAADINQNPSSPNATLTTLASSSHHSQPTADINQNPPAAITPVPQNSSQAQCSPNGTLDSKPGTLCADDGQSPVPAEEVRSSILLIDKVSAPPSAASTFSREATPLSSSGPPAADLMSSSLLIDMQPSTLVAPAEQEVPGHVAVTTPTKVYSEVHLTLAKPASVVNRTARPFGIQSPGTSQIEQSPMMGRRQFGEKAWAPPASSMADRSPQPQRHIMSRSPMVERRLLGQRSPVLERRPLGNFTPPPTYAETLSTAPVASRVRSPPSYSTLYPSSDPKPSHLKGQVAPANKTGILEESMARRGSRKSMFTFVEKPKVTPNPDLLDLVQTADEKRRQRDHGEVGMEEEPFALGAEASNFQQEPIARDRASPAAAEEAVPEWASCLKSPRIQAKPKPKPNQNLSEASGKGAELYARRQSRMEKYVIESSGHAELARCPSPTMSLPSSWKYTTNAPGGFRVASLSPARTPPASLYHGYLPENGVLRPEPTKQQPYQMRPSLYALSPVKEPAKASSRATSSRTPSRTVSPRAASPAKPSSLDLVPNLPRAGLPPSPALPRPSRSSPGLYTAPVQDSLQPTAVSPTYSSDISPVSPSRAWSPRAKQAPRPSFSTRNAGIEAQVWKPSFCFK
uniprot
proteins
function
FUNCTION: Actin-associated protein that may play a role in modulating actin-based shape and motility of dendritic spines and renal podocyte foot processes. Seems to be essential for the formation of spine apparatuses in spines of telencephalic neurons, which is involved in synaptic plasticity. {ECO:0000269|PubMed:12928494}.
uniprot
proteins
mass_dalton
99552
uniprot
proteins
post_translational_modification
PTM: O-glycosylated. {ECO:0000269|PubMed:16452088}.
uniprot
proteins
protein_family
Synaptopodin family
uniprot
proteins
pubmed
12357430
uniprot
proteins
pubmed
12928494
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
16452088
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
9314539
uniprot
proteins
sequence_length
929
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9314539}. Cell junction, tight junction {ECO:0000269|PubMed:9314539}. Perikaryon {ECO:0000269|PubMed:9314539}. Cell projection, dendritic spine {ECO:0000269|PubMed:12928494, ECO:0000269|PubMed:9314539}. Postsynaptic density {ECO:0000269|PubMed:9314539}. Synapse {ECO:0000269|PubMed:9314539}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8N3V7}. Note=Localized at the tight junction of cells. In brain, localized to the postsynaptic densities and in the perikarya. Associated with dendritic spines of a subset of synapses (PubMed:9314539). {ECO:0000269|PubMed:9314539}.
uniprot
proteins