RPL23A
entrez
6147
canonical
uniprot
P62750
canonical
ensembl
ENSG00000198242
resolver
ensp
ENSP00000389103
resolver
enst
ENST00000422514
resolver
genesymbol
RPL23A
resolver
hgnc
HGNC:10317
resolver
uniprot
B2R5B2
resolver
uniprot
P29316
resolver
uniprot
P39024
resolver
uniprot
Q92774
resolver
uniprot_entry
RL23A_HUMAN
resolver
uniprot_sec
B2R5B2
resolver
uniprot_sec
P29316
resolver
uniprot_sec
P39024
resolver
uniprot_sec
Q92774
resolver
amino_acid_sequence
MAPKAKKEAPAPPKAEAKAKALKAKKAVLKGVHSHKKKKIRTSPTFRRPKTLRLRRQPKYPRKSAPRRNKLDHYAIIKFPLTTESAMKKIEDNNTLVFIVDVKANKHQIKQAVKKLYDIDVAKVNTLIRPDGEKKAYVRLAPDYDALDVANKIGII
uniprot
proteins
function
FUNCTION: Component of the large ribosomal subunit (PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:32669547). Binds a specific region on the 26S rRNA (PubMed:23636399, PubMed:32669547). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (PubMed:26203195). {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:26203195, ECO:0000269|PubMed:32669547}.
uniprot
proteins
mass_dalton
17695
uniprot
proteins
post_translational_modification
PTM: N-terminus is methylated by METTL11A/NTM1. {ECO:0000250|UniProtKB:P62751}.; PTM: Citrullinated by PADI4. {ECO:0000250|UniProtKB:P62751}.
uniprot
proteins
protein_family
Universal ribosomal protein uL23 family
uniprot
proteins
pubmed
11682607
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22431104
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23636399
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24524803
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26203195
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
32669547
uniprot
proteins
pubmed
8662070
uniprot
proteins
pubmed
9417910
uniprot
proteins
pubmed
9687515
uniprot
proteins
sequence_length
156
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:9687515}. Nucleus {ECO:0000269|PubMed:9687515}. Note=Although RPL23A is functional within the cytoplasm, the assembly of ribosomal subunits occurs in the nucleus. RPL23A nuclear import is mediated by IPO5/RanBP5, IPO7/RanBP7, KPNB1/importin-beta or TPNO1/Trn. {ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:9687515}.
uniprot
proteins