Dgkg
entrez
25666
canonical
uniprot
P49620
canonical
ensembl
ENSRNOG00000001796
resolver
ensembl
ENSRNOG00055004952
resolver
ensembl
ENSRNOG00060011395
resolver
ensembl
ENSRNOG00065003668
resolver
ensp
ENSRNOP00000002452
resolver
ensp
ENSRNOP00000088510
resolver
ensp
ENSRNOP00000102537
resolver
ensp
ENSRNOP00055005969
resolver
ensp
ENSRNOP00060015117
resolver
ensp
ENSRNOP00065003859
resolver
enst
ENSRNOT00000105472
resolver
enst
ENSRNOT00000132290
resolver
enst
ENSRNOT00055007917
resolver
enst
ENSRNOT00060019297
resolver
enst
ENSRNOT00065005330
resolver
genesymbol
Dgkg
resolver
genesymbol_syn
Dagk3
resolver
uniprot
A0A8I6A589
resolver
uniprot_entry
A0A8I6A589_RAT
resolver
uniprot_entry
DGKG_RAT
resolver
activity_regulation
ACTIVITY REGULATION: The activity is calcium-dependent (PubMed:7809169). Requires phosphatidylserine for maximal activity (By similarity). {ECO:0000250|UniProtKB:P49619, ECO:0000269|PubMed:7809169}.
uniprot
proteins
amino_acid_sequence
MSDGQWVCLSSEEFDQLQKYSEYSSKKIKDVLAEFNEGGSLKQYDPHKPISYDVFKLFMRAYLEVDLPQPLSTNLFLAFSQKPRQETPDHPKEGASSSEPNVSDSNAESTAKADAACAPDTESKPIKTQVPSEELEAAAPWGEPNAPASSSDAPIVYLKDVVCYLSLMETGRPQDKLEFMFRLYDSDENELLDQAELDQIVSQMLHVAQYLEWDPTELRPILKEMLQGMDYNKDGFVSLEEWVSGGMTTIPLLVLLGMDDSASKGDGRHAWTLKHFKKPTYCNFCHIMLMGVRKQGLCCIYCKYAVHQRCVSNSIPGCVKTYSKAKRSGEVMQHAWVEGNSSVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKCELSTACDGGELKDHILLPTSIYPVTRDRQAGKSDSGAAAKGELVMQYKIIPSPGTHPLLVLVNPKSGGRQGERILQKFHYLLNPKQVFNLDKGGPTPGLNFFQDTPDFRVLACGGDGTVGWILDCIDKANFTKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKEIEQSPLVMLDRWYLEVMPREEVENGDQVPYNIMNNYFSIGVDASIAHRFHVMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVEVDLSNIFLEGIAILNIPSMYGGTNLWGETKKNRAVIRESRKSVTDPKELKCCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSSVTIRTKKLLPMQVDGEPWMQPPCMIKITHKNQAPMMMGPPQKSSFFSLRRKSRSKD
uniprot
proteins
ec_number
2.7.1.107
uniprot
proteins
function
FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:7809169). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (By similarity). Has no apparent specificity with regard to the acyl compositions of diacylglycerol (By similarity). Specifically expressed in the cerebellum where it controls the level of diacylglycerol which in turn regulates the activity of protein kinase C gamma. Through protein kinase C gamma, indirectly regulates the dendritic development of Purkinje cells, cerebellar long term depression and ultimately cerebellar motor coordination (By similarity). {ECO:0000250|UniProtKB:P49619, ECO:0000250|UniProtKB:Q91WG7, ECO:0000269|PubMed:7809169}.
uniprot
proteins
mass_dalton
88521
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; glycerolipid metabolism. {ECO:0000305|PubMed:7809169}.
uniprot
proteins
protein_family
Eukaryotic diacylglycerol kinase family
uniprot
proteins
pubmed
7809169
uniprot
proteins
sequence_length
788
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:7809169}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P49619}. Cytoplasm, cytoskeleton {ECO:0000305|PubMed:7809169}.
uniprot
proteins