Tpmt
entrez
22017
canonical
uniprot
O55060
canonical
ensembl
ENSMUSG00000021376
resolver
ensp
ENSMUSP00000021806
resolver
ensp
ENSMUSP00000308819
resolver
ensp
ENSMUSP00000308831
resolver
enst
ENSMUST00000021806
resolver
genesymbol
Tpmt
resolver
uniprot
A0A0R4J018
resolver
uniprot
Q9JIL7
resolver
uniprot
Q9QUG7
resolver
uniprot_entry
A0A0R4J018_MOUSE
resolver
uniprot_entry
TPMT_MOUSE
resolver
uniprot_sec
Q9JIL7
resolver
uniprot_sec
Q9QUG7
resolver
amino_acid_sequence
MSLDMKEHPDAEVQKNQVLTLEDWKEKWVTRHISFHQEQGHQLLKKHLDTFLKGQSGLRVFFPLCGKAIEMKWFADRGHTVVGVEISEIGIREFFAEQNLSYTEEPLAEIAGAKVFKSSSGSISLYCCSIFDLPRANIGKFDRIWDRGALVAINPGDHDRYADIILSLLRKEFQYLVAVLSYDPTKHAGPPFYVPSAELKRLFGTKCSMQCLEEVDALEERHKAWGLDYLFEKLYLLTEK
uniprot
proteins
ec_number
2.1.1.67
uniprot
proteins
function
FUNCTION: Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) using S-adenosyl-L-methionine as the methyl donor (PubMed:18484748). TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified. {ECO:0000269|PubMed:18484748, ECO:0000305}.
uniprot
proteins
mass_dalton
27586
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
TPMT family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18484748
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9539138
uniprot
proteins
sequence_length
240
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins