Eps8
entrez
13860
canonical
uniprot
Q08509
canonical
ensembl
ENSMUSG00000015766
resolver
ensp
ENSMUSP00000052776
resolver
ensp
ENSMUSP00000098402
resolver
ensp
ENSMUSP00000107509
resolver
ensp
ENSMUSP00000274357
resolver
ensp
ENSMUSP00000274365
resolver
enst
ENSMUST00000058210
resolver
enst
ENSMUST00000100841
resolver
enst
ENSMUST00000111878
resolver
genesymbol
Eps8
resolver
uniprot
Q3TM41
resolver
uniprot
Q3U2Z5
resolver
uniprot
Q3UFL4
resolver
uniprot_entry
EPS8_MOUSE
resolver
uniprot_entry
Q3U2Z5_MOUSE
resolver
uniprot_entry
Q3UFL4_MOUSE
resolver
uniprot_sec
Q3TM41
resolver
amino_acid_sequence
MNGHMSNRSSGYGVYPSQLNGYGSSPPYSQMDREHSSRTSAKALYEQRKNYARDSVSSVSDVSQYRVEHLTTFVLDRKDAMITVEDGIRKLKLLDAKGKVWTQDMILQVDDRAVSLIDLESKNELENFPLNTISHCQAVVHACSYDSILALVCKEPTQSKPDLHLFQCDEVKANLISEDIESAISDSKGGKQKRRPEALRMIAKADPGIPPPPRAPAPVPPGTVTQVDVRSRVAAWSAWAADQGDFEKPRQYHEQEETPEMMAARIDRDVQILNHILDDIEFFITKLQKAAEAFSELSKRKKSKKSKRKGPGEGVLTLRAKPPPPDEFVDCFQKFKHGFNLLAKLKSHIQNPSASDLVHFLFTPLNMVVQATGGPELASSVLSPLLTKDTVDFLNYTATAEERKLWMSLGDSWVKVRAEWPKEQFIPPYVPRFRNGWEPPMLNFMGAPTEQDMYQLAESVANAEHQRKQDSKRLSTEHSNVSDYPPADGYAYSSSMYHRGPHADHGEAAMPFKSTPNHQVDRNYDAVKTQPKKYAKSKYDFVARNSSELSVMKDDVLEILDDRRQWWKVRNASGDSGFVPNNILDIMRTPESGVGRADPPYTHTIQKQRTEYGLRSADTPSAPSPPPTPAPVPVPLPPSVPAPVSVPKVPANVTRQNSSSSDSGGSIVRDSQRYKQLPVDRRKSQMEEVQDELFQRLTIGRSAAQRKFHVPRQNVPVINITYDSSPEEVKTWLQSKGFNPVTVNSLGVLNGAQLFSLNKDELRSVCPEGARVFNQITVQKAALEDSNGSSELQEIMRRRQEKISAAASDSGVESFDEGSSH
uniprot
proteins
function
FUNCTION: Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filopodia growth, stereocilia length, dendritic cell migration and cancer cell migration and invasion. Acts as a regulator of axonal filopodia formation in neurons: in the absence of neurotrophic factors, negatively regulates axonal filopodia formation via actin-capping activity. In contrast, it is phosphorylated in the presence of BDNF leading to inhibition of its actin-capping activity and stimulation of filopodia formation. Component of a complex with WHRN and MYO15A that localizes at stereocilia tips and is required for elongation of the stereocilia actin core. Indirectly involved in cell cycle progression; its degradation following ubiquitination being required during G2 phase to promote cell shape changes. {ECO:0000269|PubMed:10499589, ECO:0000269|PubMed:11524436, ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:17115031, ECO:0000269|PubMed:19564905, ECO:0000269|PubMed:20532239, ECO:0000269|PubMed:21236676, ECO:0000269|PubMed:21835647, ECO:0000269|PubMed:8404850}.
uniprot
proteins
mass_dalton
91737
uniprot
proteins
mutagenesis
MUTAGEN 624; /note="S->A: Does not detach from actin following BDNF treatment; when associated with A-628."; /evidence="ECO:0000269|PubMed:19564905"; MUTAGEN 624; /note="S->E: Mimicks phosphorylation state; promotes detachment from actin in absence of BDNF treatment; when associated with E-628."; /evidence="ECO:0000269|PubMed:19564905"; MUTAGEN 628; /note="T->A: Does not detach from actin following BDNF treatment; when associated with A-624."; /evidence="ECO:0000269|PubMed:19564905"; MUTAGEN 628; /note="T->E: Mimicks phosphorylation state; promotes detachment from actin in absence of BDNF treatment; when associated with E-624."; /evidence="ECO:0000269|PubMed:19564905"; MUTAGEN 689; /note="V->D: Abolishes barbed-end actin-binding without affecting actin bundling activity."; /evidence="ECO:0000269|PubMed:20532239"; MUTAGEN 693; /note="L->D: Abolishes barbed-end actin-binding without affecting actin bundling activity."; /evidence="ECO:0000269|PubMed:20532239"; MUTAGEN 706; /note="R->A: Impairs both actin capping and bundling activities."; /evidence="ECO:0000269|PubMed:20532239"; MUTAGEN 708; /note="F->A: Impairs both actin capping and bundling activities."; /evidence="ECO:0000269|PubMed:20532239
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the SCF(FBXW5) E3 ubiquitin-protein ligase complex during G2 phase, leading to its transient degradation and subsequent cell shape changes required to allow mitotic progression. Reappears at the midzone of dividing cells. {ECO:0000269|PubMed:23314863}.; PTM: Phosphorylation at Ser-624 and Thr-628 by MAPK following BDNF treatment promotes removal from actin and filopodia formation. Phosphorylated by several receptor tyrosine kinases. {ECO:0000269|PubMed:19564905, ECO:0000269|PubMed:8404850}.
uniprot
proteins
protein_family
EPS8 family
uniprot
proteins
pubmed
10499589
uniprot
proteins
pubmed
11524436
uniprot
proteins
pubmed
12127568
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15558031
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17115031
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19528316
uniprot
proteins
pubmed
19564905
uniprot
proteins
pubmed
20532239
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21236676
uniprot
proteins
pubmed
21835647
uniprot
proteins
pubmed
23314863
uniprot
proteins
pubmed
23918390
uniprot
proteins
pubmed
24741995
uniprot
proteins
pubmed
7537362
uniprot
proteins
pubmed
8404850
uniprot
proteins
pubmed
9303002
uniprot
proteins
sequence_length
821
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cell cortex. Cell projection, ruffle membrane. Cell projection, growth cone {ECO:0000250}. Cell projection, stereocilium {ECO:0000269|PubMed:23918390, ECO:0000269|PubMed:24741995}. Synapse, synaptosome {ECO:0000250}. Note=Localizes at the tips of the stereocilia of the inner and outer hair cells (PubMed:23918390, PubMed:24741995). Localizes to the midzone of dividing cells. {ECO:0000269|PubMed:23918390, ECO:0000269|PubMed:24741995}.
uniprot
proteins