CORIN
entrez
10699
canonical
uniprot
Q9Y5Q5
canonical
ensembl
ENSG00000145244
resolver
ensp
ENSP00000273857
resolver
ensp
ENSP00000423216
resolver
ensp
ENSP00000484087
resolver
enst
ENST00000504584
resolver
enst
ENST00000610355
resolver
genesymbol
CORIN
resolver
genesymbol_syn
CRN
resolver
genesymbol_syn
TMPRSS10
resolver
hgnc
HGNC:19012
resolver
uniprot
A0A087X1D5
resolver
uniprot
B0ZBE3
resolver
uniprot
B4E1Y7
resolver
uniprot
B4E2W9
resolver
uniprot
J3KR83
resolver
uniprot
Q2TBD2
resolver
uniprot
Q4W5E5
resolver
uniprot
Q4W5G6
resolver
uniprot
Q9UHY2
resolver
uniprot_entry
A0A087X1D5_HUMAN
resolver
uniprot_entry
B4E1Y7_HUMAN
resolver
uniprot_entry
B4E2W9_HUMAN
resolver
uniprot_entry
CORIN_HUMAN
resolver
uniprot_entry
J3KR83_HUMAN
resolver
uniprot_sec
B0ZBE3
resolver
uniprot_sec
Q2TBD2
resolver
uniprot_sec
Q4W5E5
resolver
uniprot_sec
Q4W5G6
resolver
uniprot_sec
Q9UHY2
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited in a dose-dependent manner by non-specific trypsin-like serine protease inhibitors including benzamidine.
uniprot
proteins
amino_acid_sequence
MKQSPALAPEERCRRAGSPKPVLRADDNNMGNGCSQKLATANLLRFLLLVLIPCICALVLLLVILLSYVGTLQKVYFKSNGSEPLVTDGEIQGSDVILTNTIYNQSTVVSTAHPDQHVPAWTTDASLPGDQSHRNTSACMNITHSQCQMLPYHATLTPLLSVVRNMEMEKFLKFFTYLHRLSCYQHIMLFGCTLAFPECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRCSQFRNQTESSNVSRICFSPQQENGKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCNCSENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTTEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCSCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSFCQDDELECANHACVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHHVCADGWQEILSQLACKQMGLGEPSVTKLIQEQEKEPRWLTLHSNWESLNGTTLHELLVNGQSCESRSKISLLCTKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFEGRENAAVWKVVLGINNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSEDISETGYVRPVCLPNPEQWLEPDTYCYITGWGHMGNKMPFKLQEGEVRIISLEHCQSYFDMKTITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLGPGVYSNVSYFVEWIKRQIYIQTFLLN
uniprot
proteins
disease_involvement
DISEASE: Pre-eclampsia/eclampsia 5 (PEE5) [MIM:614595]: A hypertensive disorder of pregnancy characterized by new hypertension (blood pressure 140/90 or greater) presenting after 20 weeks' gestation with clinically relevant proteinuria. It impacts 2 individuals, the mother and her child, both of whom can be severely affected. Preeclampsia is one of the causes of maternal mortality and morbidity worldwide. {ECO:0000269|PubMed:22437503}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Cardiomyopathy, familial hypertrophic, 30, atrial (CMH30) [MIM:620734]: An autosomal recessive heart disease characterized by enlarged and thickened left atrium, left atrial fibrosis, atrial arrhythmias, and hypertension. {ECO:0000269|PubMed:37913506}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Serine-type endopeptidase involved in atrial natriuretic peptide (NPPA) and brain natriuretic peptide (NPPB) processing (PubMed:10880574, PubMed:20489134, PubMed:21288900, PubMed:21763278). Converts through proteolytic cleavage the non-functional propeptides NPPA and NPPB into their active hormones, ANP and BNP(1-32) respectively, thereby regulating blood pressure in the heart and promoting natriuresis, diuresis and vasodilation (PubMed:10880574, PubMed:20489134, PubMed:21288900, PubMed:21763278). Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus (PubMed:22437503). Also acts as a regulator of sodium reabsorption in kidney (By similarity). {ECO:0000250|UniProtKB:Q9Z319, ECO:0000269|PubMed:10880574, ECO:0000269|PubMed:20489134, ECO:0000269|PubMed:21288900, ECO:0000269|PubMed:21763278, ECO:0000269|PubMed:22437503}.; FUNCTION: [Isoform 2]: Has weaker endopeptidase activity compared to isoform 1.
uniprot
proteins
mass_dalton
116486
uniprot
proteins
mutagenesis
MUTAGEN 26; /note="D->A: Impairs cell membrane targeting; when associated with A-30."; /evidence="ECO:0000269|PubMed:21518754"; MUTAGEN 30; /note="M->A: Impairs cell membrane targeting; when associated with A-26."; /evidence="ECO:0000269|PubMed:21518754"; MUTAGEN 134; /note="R->A: Does not affect autocatalytic cleavage."; /evidence="ECO:0000269|PubMed:21288900"; MUTAGEN 164; /note="R->A: Affects autocatalytic cleavage and production of Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment."; /evidence="ECO:0000269|PubMed:21288900"; MUTAGEN 180; /note="R->A: Does not affect autocatalytic cleavage."; /evidence="ECO:0000269|PubMed:21288900"; MUTAGEN 213; /note="R->A: Does not affect autocatalytic cleavage."; /evidence="ECO:0000269|PubMed:21288900"; MUTAGEN 239; /note="R->A: Does not affect autocatalytic cleavage."; /evidence="ECO:0000269|PubMed:21288900"; MUTAGEN 244; /note="R->A: Does not affect autocatalytic cleavage."; /evidence="ECO:0000269|PubMed:21288900"; MUTAGEN 427; /note="R->A: Affects autocatalytic cleavage and production of Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment."; /evidence="ECO:0000269|PubMed:21288900"; MUTAGEN 801; /note="R->A: Loss of activity towards NPPA."; /evidence="ECO:0000269|PubMed:14559895, ECO:0000269|PubMed:21288900"; MUTAGEN 985; /note="S->A: Loss of activity towards NPPA."; /evidence="ECO:0000269|PubMed:10880574, ECO:0000269|PubMed:14559895, ECO:0000269|PubMed:21288900
uniprot
proteins
post_translational_modification
PTM: N-glycosylated; required for processing and activation. {ECO:0000269|PubMed:17660514, ECO:0000269|PubMed:21518754}.; PTM: Activated through proteolytic processing by a trypsin-like protease; cleaved into a N-terminal propeptide and an activated corin protease fragment. Different soluble forms are produced by cleavage and autocatalytic cleavage: Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment is produced by cleavage by ADAM10, while 160 kDa and 100 kDa soluble fragments are produced by autocatalytic cleavage. Cleavage by ADAM10 to produce soluble 180 kDa soluble fragment takes place after the transmembrane region and before FZ 1.; PTM: A disulfide bond links the activated corin protease fragment and the N-terminal propeptide. The disulfide bond also links the activated corin protease fragment with soluble fragments (100 kDa, 160 kDa and 180 kDa fragments).
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
10329693
uniprot
proteins
pubmed
10880574
uniprot
proteins
pubmed
11082206
uniprot
proteins
pubmed
14559895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17660514
uniprot
proteins
pubmed
17918732
uniprot
proteins
pubmed
19751717
uniprot
proteins
pubmed
20489134
uniprot
proteins
pubmed
21288900
uniprot
proteins
pubmed
21518754
uniprot
proteins
pubmed
21763278
uniprot
proteins
pubmed
22437503
uniprot
proteins
pubmed
37913506
uniprot
proteins
sequence_length
1042
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19751717, ECO:0000269|PubMed:21288900, ECO:0000269|PubMed:21518754}; Single-pass type II membrane protein {ECO:0000269|PubMed:19751717, ECO:0000269|PubMed:21288900, ECO:0000269|PubMed:21518754}. Note=May easily detach from the endothelial cell membrane.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type II membrane protein. Note=Less efficiently targeted to the cell membrane compared to isoform 1.; SUBCELLULAR LOCATION: [Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment]: Secreted. Note=Soluble form produced following cleavage by ADAM10.; SUBCELLULAR LOCATION: [Atrial natriuretic peptide-converting enzyme, 160 kDa soluble fragment]: Secreted. Note=Soluble form produced following autocatalytic cleavage.; SUBCELLULAR LOCATION: [Atrial natriuretic peptide-converting enzyme, 100 kDa soluble fragment]: Secreted. Note=Soluble form produced following autocatalytic cleavage.
uniprot
proteins
transmembrane_region
TRANSMEM 46..66; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins