Babam2
entrez
107976
canonical
uniprot
Q8K3W0
canonical
ensembl
ENSMUSG00000052139
resolver
ensp
ENSMUSP00000069133
resolver
ensp
ENSMUSP00000071462
resolver
ensp
ENSMUSP00000110152
resolver
ensp
ENSMUSP00000128351
resolver
ensp
ENSMUSP00000144205
resolver
genesymbol
Babam2
resolver
genesymbol_syn
Bre
resolver
uniprot
Q497G6
resolver
uniprot
Q6P8Z2
resolver
uniprot
Q8BKU1
resolver
uniprot
Q8CJ13
resolver
uniprot
Q8JZP0
resolver
uniprot
Q8K3V9
resolver
uniprot
Q8VHN1
resolver
uniprot_entry
BABA2_MOUSE
resolver
uniprot_sec
Q497G6
resolver
uniprot_sec
Q6P8Z2
resolver
uniprot_sec
Q8BKU1
resolver
uniprot_sec
Q8CJ13
resolver
uniprot_sec
Q8JZP0
resolver
uniprot_sec
Q8K3V9
resolver
uniprot_sec
Q8VHN1
resolver
amino_acid_sequence
MSPEIALNRISPMLSPFISSVVRNGKVGLDATNCLRITDLKSGCTSLTPGPNCDRFKLHIPYAGETLKWDIIFNAQYPELPPDFIFGEDAEFLPDPSALHNLASWNPSNPECLLLVVKELVQQYHQFQCGRLRESSRLMFEYQTLLEEPQYGENMEIYAGKKNNWTGEFSARFLLKLPVDFSNIPTYLLKDVNEDPGEDVALLSVSFEDTEATQVYPKLYLSPRIEHALGGSSALHIPAFPGGGCLIDYVPQVCHLLTNKVQYVIQGYHKRREYIAAFLSHFGTGVVEYDAEGFTKLTLLLMWKDFCFLVHIDLPLFFPRDQPTLTFQSVYHFTNSGQLYSQAQKNYPYSPRWDGNEMAKRAKAYFKTFVPQFQEAAFANGKL
uniprot
proteins
function
FUNCTION: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin (By similarity). May regulate TNF signaling through its interactions with TNFRSF1A. {ECO:0000250, ECO:0000269|PubMed:9737713}.; FUNCTION: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1. The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression. Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination. May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins (By similarity). May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF signaling through its interactions with TNFRSF1A; however these effects may be indirect (PubMed:9737713). {ECO:0000250|UniProtKB:Q9NXR7, ECO:0000305|PubMed:9737713}.
uniprot
proteins
mass_dalton
43545
uniprot
proteins
protein_family
BABAM2 family
uniprot
proteins
pubmed
11676476
uniprot
proteins
pubmed
14565866
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9737713
uniprot
proteins
sequence_length
383
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9NXR7}. Nucleus {ECO:0000250|UniProtKB:Q9NXR7}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). {ECO:0000250|UniProtKB:Q9NXR7}.
uniprot
proteins