Grb7
entrez
84427
canonical
uniprot
Q9QZC5
canonical
ensembl
ENSRNOG00000006990
resolver
ensp
ENSRNOP00000009299
resolver
genesymbol
Grb7
resolver
uniprot_entry
GRB7_RAT
resolver
amino_acid_sequence
MELDLSPSHLSSSPEDVCPTPGTPPETPPPPDNPPPGDVKRSQPLPIPSSRKLREEEFQATSLPSIPNPFPELCSPPSQKPILGGSSGARGLLPRDSSRLCVVKVYSEDGACRSVEVAAGATARHVCEMLVQRAHALSDENWGLVECHPYLALERGLEDHESVVEVQEAWPVGGDSRFIFRKNFAKYELFKSPPHTLFPEKMVSSCLDTPTGISHEDLIQNFLNAGSFPEIQGFLQLRGSGRGSGRKLWKRFFCFLRRSGLYYSTKGTSKDPRHLQYVADINESNVYVVTQGRKLYGIPTDFGFCVKPNKLRNGHKGLHIFCSEDEQSRTCWLSAFRLFKYGVQLYKNYQQAQSRHLRLSYLGSPPLRSVSDNTLVAMDFSGHAGRVIENPQEALSAATEEAQAWRKKTNHRLSLPTPCSGLSLSAAIHRTQPWFHGRISREESQRLIGQQGLVDGVFLVRESQRNPQGFVLSLCHLQKVKHYLILPSEDEGCLYFSMDDGQTRFTDLLQLVEFHQLNRGILPCLLRHCCARVAL
uniprot
proteins
function
FUNCTION: Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
59889
uniprot
proteins
mutagenesis
MUTAGEN 461; /note="R->K: Reduces interaction with INSR."; /evidence="ECO:0000269|PubMed:10803466
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine and threonine residues in response to activation of receptor kinases. Phosphorylated on tyrosine residues by TEK/TIE2. Phosphorylated on tyrosine residues by PTK2/FAK1, and possibly also other kinases. Phosphorylation is enhanced by activation of receptor kinases by a cognate ligand. Tyrosine phosphorylation is essential for activation of down-stream protein kinases. Phosphorylation decreases affinity for target mRNA molecules (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
GRB7/10/14 family
uniprot
proteins
pubmed
10803466
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
535
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q14451}. Cell projection {ECO:0000250|UniProtKB:Q14451}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q14451}. Cell membrane {ECO:0000250|UniProtKB:Q14451}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14451}; Cytoplasmic side {ECO:0000250|UniProtKB:Q14451}. Cytoplasmic granule {ECO:0000250|UniProtKB:Q03160}. Note=Predominantly cytoplasmic. Detected in stress granules where mRNA is stored under stress conditions. {ECO:0000250|UniProtKB:Q03160}.
uniprot
proteins