CBX5
entrez
23468
canonical
uniprot
P45973
canonical
ensembl
ENSG00000094916
resolver
ensp
ENSP00000209875
resolver
ensp
ENSP00000401009
resolver
ensp
ENSP00000449207
resolver
ensp
ENSP00000552144
resolver
ensp
ENSP00000552146
resolver
ensp
ENSP00000552147
resolver
ensp
ENSP00000552148
resolver
ensp
ENSP00000552149
resolver
ensp
ENSP00000552151
resolver
ensp
ENSP00000552152
resolver
ensp
ENSP00000552153
resolver
ensp
ENSP00000552154
resolver
ensp
ENSP00000600448
resolver
ensp
ENSP00000600450
resolver
ensp
ENSP00000600451
resolver
ensp
ENSP00000600452
resolver
ensp
ENSP00000600453
resolver
ensp
ENSP00000600454
resolver
ensp
ENSP00000600455
resolver
ensp
ENSP00000600456
resolver
enst
ENST00000209875
resolver
enst
ENST00000439541
resolver
enst
ENST00000550411
resolver
enst
ENST00000882085
resolver
enst
ENST00000882087
resolver
enst
ENST00000882088
resolver
enst
ENST00000882089
resolver
enst
ENST00000882090
resolver
enst
ENST00000882092
resolver
enst
ENST00000882093
resolver
enst
ENST00000882094
resolver
enst
ENST00000882095
resolver
enst
ENST00000930389
resolver
enst
ENST00000930391
resolver
enst
ENST00000930392
resolver
enst
ENST00000930393
resolver
enst
ENST00000930394
resolver
enst
ENST00000930395
resolver
enst
ENST00000930396
resolver
enst
ENST00000930397
resolver
genesymbol
CBX5
resolver
genesymbol
HEL25
resolver
genesymbol_syn
HP1A
resolver
hgnc
HGNC:1555
resolver
uniprot
B2R8T9
resolver
uniprot
V9HWG0
resolver
uniprot_entry
CBX5_HUMAN
resolver
uniprot_entry
V9HWG0_HUMAN
resolver
uniprot_sec
B2R8T9
resolver
amino_acid_sequence
MGKKTKRTADSSSSEDEEEYVVEKVLDRRVVKGQVEYLLKWKGFSEEHNTWEPEKNLDCPELISEFMKKYKKMKEGENNKPREKSESNKRKSNFSNSADDIKSKKKREQSNDIARGFERGLEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKCPQIVIAFYEERLTWHAYPEDAENKEKETAKS
uniprot
proteins
function
FUNCTION: Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression (PubMed:40440427). In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph) (PubMed:19783980). Also recognizes and binds histone H1.4 methylated at 'Lys-26' (H1.4K26me) (PubMed:16127177). Excluded from chromatin when histone H1.4 is Simultaneously methylated at Lys-26 (H1.4K26me) and phosphorylated at Ser-27 (H1.4S27Ph) (PubMed:16127177). May contribute to the association of heterochromatin with the inner nuclear membrane by interactions with the lamin-B receptor (LBR) (PubMed:19783980). Involved in the formation of kinetochore through interaction with the MIS12 complex subunit NSL1 (PubMed:19783980, PubMed:20231385). Required for the formation of the inner centromere (PubMed:20231385). {ECO:0000269|PubMed:16127177, ECO:0000269|PubMed:19783980, ECO:0000269|PubMed:20231385, ECO:0000269|PubMed:40440427}.
uniprot
proteins
mass_dalton
22225
uniprot
proteins
mutagenesis
MUTAGEN 165; /note="I->E: No effect on interaction with POGZ. Abolishes interaction with TRIM28, CHAF1A and NIPBL. Abolishes interaction with NSL1."; /evidence="ECO:0000269|PubMed:20231385, ECO:0000269|PubMed:20562864"; MUTAGEN 173; /note="T->D,K: Abolishes interaction with NSL1."; /evidence="ECO:0000269|PubMed:20231385"; MUTAGEN 174; /note="W->A: Abolishes interaction with TRIM28, CHAF1A, NIPBL and HP1BP3, fails to localize to centromeres in mitosis. Abolishes interaction with NSL1."; /evidence="ECO:0000269|PubMed:20042602, ECO:0000269|PubMed:20231385, ECO:0000269|PubMed:20562864, ECO:0000269|PubMed:21346195
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of HP1 and LBR may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle (By similarity). Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis. {ECO:0000250, ECO:0000269|PubMed:10460410}.; PTM: Ubiquitinated. {ECO:0000269|PubMed:20498703}.
uniprot
proteins
pubmed
10460410
uniprot
proteins
pubmed
11242053
uniprot
proteins
pubmed
11313457
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15502821
uniprot
proteins
pubmed
15864296
uniprot
proteins
pubmed
15882967
uniprot
proteins
pubmed
15899859
uniprot
proteins
pubmed
16127177
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19617346
uniprot
proteins
pubmed
19666599
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19710015
uniprot
proteins
pubmed
19783980
uniprot
proteins
pubmed
19880879
uniprot
proteins
pubmed
20042602
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20231385
uniprot
proteins
pubmed
20498703
uniprot
proteins
pubmed
20562864
uniprot
proteins
pubmed
20819937
uniprot
proteins
pubmed
20850016
uniprot
proteins
pubmed
21047797
uniprot
proteins
pubmed
21199919
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21346195
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23542155
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25750265
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
25906157
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28977666
uniprot
proteins
pubmed
32051553
uniprot
proteins
pubmed
40440427
uniprot
proteins
pubmed
8505380
uniprot
proteins
pubmed
8663349
uniprot
proteins
pubmed
9169472
uniprot
proteins
sequence_length
191
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10460410, ECO:0000269|PubMed:19617346, ECO:0000269|PubMed:28977666}. Chromosome {ECO:0000269|PubMed:10460410, ECO:0000269|PubMed:40440427}. Chromosome, centromere {ECO:0000269|PubMed:10460410, ECO:0000269|PubMed:20231385, ECO:0000269|PubMed:21346195}. Note=Colocalizes with HNRNPU in the nucleus (PubMed:19617346). Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis (PubMed:40440427). Associates specifically with chromatin during metaphase and anaphase (PubMed:19617346). Localizes to sites of DNA damage (PubMed:28977666). {ECO:0000269|PubMed:19617346, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:40440427}.
uniprot
proteins