NEXN
entrez
91624
canonical
uniprot
Q0ZGT2
canonical
ensembl
ENSG00000162614
resolver
ensp
ENSP00000327363
resolver
ensp
ENSP00000333938
resolver
ensp
ENSP00000343928
resolver
ensp
ENSP00000521102
resolver
genesymbol
NEXN
resolver
hgnc
HGNC:29557
resolver
uniprot
A0PJ84
resolver
uniprot
B4DDI0
resolver
uniprot
B4DPZ7
resolver
uniprot
Q0D2H2
resolver
uniprot
Q14CC2
resolver
uniprot
Q14CC3
resolver
uniprot
Q16081
resolver
uniprot
Q7Z2X0
resolver
uniprot
Q96DL0
resolver
uniprot
Q9Y2V1
resolver
uniprot_entry
B4DDI0_HUMAN
resolver
uniprot_entry
NEXN_HUMAN
resolver
uniprot_sec
A0PJ84
resolver
uniprot_sec
B4DPZ7
resolver
uniprot_sec
Q0D2H2
resolver
uniprot_sec
Q14CC2
resolver
uniprot_sec
Q14CC3
resolver
uniprot_sec
Q16081
resolver
uniprot_sec
Q7Z2X0
resolver
uniprot_sec
Q96DL0
resolver
uniprot_sec
Q9Y2V1
resolver
amino_acid_sequence
MNDISQKAEILLSSSKPVPKTYVPKLGKGDVKDKFEAMQRAREERNQRRSRDEKQRRKEQYIREREWNRRKQEIKEMLASDDEEDVSSKVEKAYVPKLTGTVKGRFAEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGDDSLLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKYEEDKRIRYEEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEELLKQKMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEEENETFGLSREYEELIKLKRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDVRPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREEEEEEEGSIMNGSTAEDEEQTRSGAPWFKKPLKNTSVVDSEPVRFTVKVTGEPKPEITWWFEGEILQDGEDYQYIERGETYCLYLPETFPEDGGEYMCKAVNNKGSAASTCILTIESKN
uniprot
proteins
disease_involvement
DISEASE: Cardiomyopathy, dilated, 1CC (CMD1CC) [MIM:613122]: An autosomal dominant form of dilated cardiomyopathy, a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. {ECO:0000269|PubMed:19881492}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Cardiomyopathy, dilated, 2M (CMD2M) [MIM:621261]: A form of dilated cardiomyopathy, a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. CMD2M is an autosomal recessive, severe form characterized by fetal or perinatal death or by severe symptoms in infants. {ECO:0000269|PubMed:33949776, ECO:0000269|PubMed:35166435, ECO:0000269|PubMed:38059363}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Cardiomyopathy, familial hypertrophic, 20 (CMH20) [MIM:613876]: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. {ECO:0000269|PubMed:20970104, ECO:0000269|PubMed:32410525}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Involved in regulating cell migration through association with the actin cytoskeleton. Has an essential role in the maintenance of Z line and sarcomere integrity. {ECO:0000269|PubMed:12053183, ECO:0000269|PubMed:15823560, ECO:0000269|PubMed:19881492}.
uniprot
proteins
mass_dalton
80658
uniprot
proteins
pubmed
12053183
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15823560
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19881492
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20970104
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
32410525
uniprot
proteins
pubmed
33949776
uniprot
proteins
pubmed
35166435
uniprot
proteins
pubmed
38059363
uniprot
proteins
pubmed
8227983
uniprot
proteins
sequence_length
675
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9Z2J4}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9Z2J4}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:Q9Z2J4}. Note=Localizes to the cell-matrix AJ. Not found at the cell-cell AJ. {ECO:0000250|UniProtKB:Q9Z2J4}.
uniprot
proteins