Sult1e1
entrez
360268
canonical
uniprot
P52844
canonical
ensembl
ENSRNOG00000001957
resolver
ensembl
ENSRNOG00055016876
resolver
ensembl
ENSRNOG00060012715
resolver
ensembl
ENSRNOG00065005349
resolver
ensp
ENSRNOP00000002680
resolver
ensp
ENSRNOP00055023107
resolver
ensp
ENSRNOP00060017071
resolver
ensp
ENSRNOP00065005498
resolver
enst
ENSRNOT00000002680
resolver
enst
ENSRNOT00055028691
resolver
enst
ENSRNOT00060021603
resolver
enst
ENSRNOT00065007900
resolver
genesymbol
Sult1e1
resolver
genesymbol_syn
Ste
resolver
genesymbol_syn
Ste1
resolver
genesymbol_syn
Ste2
resolver
genesymbol_syn
ste2
resolver
uniprot
P49889
resolver
uniprot
P49890
resolver
uniprot
P52845
resolver
uniprot
Q99ND5
resolver
uniprot
Q9QWS0
resolver
uniprot_entry
Q99ND5_RAT
resolver
uniprot_entry
ST1E1_RAT
resolver
uniprot_sec
P49889
resolver
uniprot_sec
P49890
resolver
uniprot_sec
P52845
resolver
uniprot_sec
Q9QWS0
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by estradiol. {ECO:0000250|UniProtKB:P49888}.
uniprot
proteins
amino_acid_sequence
METSMPEYYEVFGDFHGVLMDKLFTKYWEDVETFSARPDDLLVVTYPKSGSTWIGEIVDMIYKEGDVEKCKEDAIFNRIPYLECRNEDLINGIKQLKEKESPRIVKTHLPAKLLPASFWEKNCKIIYLCRNAKDVVVSYYYFFLIIKSYPNPKSFSEFVEKFMEGQVPYGSWYDHVKSWWEKSKNSRVLFMFYEDMKEDIRREVVKLIEFLERDPLAELVDKIIQHTSFQEMKNNPCTNYSMLPETMIDLKVSPFMRKGIVGDWRNHFPEALRERFEEHYQRHMKDCPVKFRAEL
uniprot
proteins
ec_number
2.8.2.4
uniprot
proteins
function
FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (PubMed:7857871). Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone (DHEA), pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency. Does not sulfonate cortisol, testosterone and dopamine. May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system. {ECO:0000250|UniProtKB:P49888, ECO:0000269|PubMed:7857871}.
uniprot
proteins
mass_dalton
35362
uniprot
proteins
protein_family
Sulfotransferase 1 family
uniprot
proteins
pubmed
12173467
uniprot
proteins
pubmed
1374839
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7857871
uniprot
proteins
pubmed
8688469
uniprot
proteins
sequence_length
295
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P49887}.
uniprot
proteins