ICAM4
entrez
3386
canonical
uniprot
Q14773
canonical
ensembl
ENSG00000105371
resolver
ensp
ENSP00000342114
resolver
ensp
ENSP00000370147
resolver
genesymbol
ICAM4
resolver
genesymbol_syn
LW
resolver
hgnc
HGNC:5347
resolver
uniprot
A0M8X2
resolver
uniprot
Q14771
resolver
uniprot
Q14772
resolver
uniprot
Q16375
resolver
uniprot
Q9BWR0
resolver
uniprot
U5U6P8
resolver
uniprot_entry
ICAM4_HUMAN
resolver
uniprot_entry
U5U6P8_HUMAN
resolver
uniprot_sec
A0M8X2
resolver
uniprot_sec
Q14771
resolver
uniprot_sec
Q14772
resolver
uniprot_sec
Q16375
resolver
uniprot_sec
Q9BWR0
resolver
amino_acid_sequence
MGSLFPLSLLFFLAAAYPGVGSALGRRTKRAQSPKGSPLAPSGTSVPFWVRMSPEFVAVQPGKSVQLNCSNSCPQPQNSSLRTPLRQGKTLRGPGWVSYQLLDVRAWSSLAHCLVTCAGKTRWATSRITAYKPPHSVILEPPVLKGRKYTLRCHVTQVFPVGYLVVTLRHGSRVIYSESLERFTGLDLANVTLTYEFAAGPRDFWQPVICHARLNLDGLVVRNSSAPITLMLAWSPAPTALASGSIAALVGILLTVGAAYLCKCLAMKSQA
uniprot
proteins
function
FUNCTION: Functions as a receptor ligand for the monocyte/macrophage-specific ITGAX:ITGB2 integrin complex and mediates erythrophagocytosis (PubMed:16985175). Receptor ligand of the platelet-specific ITGA2B:ITGB3 integrin complex involved in heterotypic cell-cell adhesion between erythrocytes and activated platelets (PubMed:12477717, PubMed:15355350). In vitro, is also a receptor ligand of multiple integrin receptors complexes such ITGAL:ITGB2, ITGAM:ITGB2, ITGA5:ITGB1, ITGA5:ITGB3 and ITGA5:ITGB5 integrin complexes (PubMed:10846180, PubMed:11435317, PubMed:15355350). {ECO:0000269|PubMed:10846180, ECO:0000269|PubMed:11435317, ECO:0000269|PubMed:12477717, ECO:0000269|PubMed:15355350, ECO:0000269|PubMed:16985175}.
uniprot
proteins
mass_dalton
29265
uniprot
proteins
post_translational_modification
PTM: N- and O-glycosylated. {ECO:0000269|PubMed:11435317}.
uniprot
proteins
protein_family
ICAM family
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
10846180
uniprot
proteins
pubmed
11435317
uniprot
proteins
pubmed
12477717
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15355350
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16985175
uniprot
proteins
pubmed
7632968
uniprot
proteins
pubmed
8202485
uniprot
proteins
pubmed
8639917
uniprot
proteins
sequence_length
271
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform Long]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform Short]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9ERM2}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 241..261; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins