Pwwp3a
entrez
362838
canonical
uniprot
B1H224
canonical
ensembl
ENSRNOG00000024549
resolver
ensp
ENSRNOP00000057438
resolver
enst
ENSRNOT00000060708
resolver
genesymbol
Pwwp3a
resolver
genesymbol_syn
Mum1
resolver
uniprot
A0A8L2QRY6
resolver
uniprot_entry
A0A8L2QRY6_RAT
resolver
uniprot_entry
PWP3A_RAT
resolver
amino_acid_sequence
MTDAKYVLCRWEKRLWPAKVLARTETSAKNKRKKEFFLDVQILSLKEKIQVKSSAVEALQKSHIENIAAFLASQNEVPATPLEELTYRRSLRVALDVLNERTSLSPESHPVENGSTPSQKGKPDADMASQVSSAPSPSFLSEDDQAVAAQCASKRRWECSPKSLSPLSASEEDLRCKVDPKTGLSESGALGTEVPAPTGDESQNGSGSQLDHGQESTTKKRQRNSGEKPARRGKAESGLSKGDSVAESGGQASSCVALASPRLPSQTWEGDPCAGVEGCDPVESSGNIRPLLDSERSKGRLTKRPRLDGGRNPLPRHLGTRTVGAVPSRRSCSGEVTTLRRAGDSDRPEEADPMSSEESTGFKSVHSLLEEEEEEEEEEEEEEEPPRILLYHEPRSFEVGMLVWLKYQKYPFWPAVVKSVRRRDKKASVLFIEGNMNPKGRGITVSLRRLKHFDCKEKHALLDRAKEDFAQAIGWCVSLITDYRVRLGCGSFAGSFLEYYAADISYPVRKSIQQDVLGTRFPQLGKGDPEEPMGDSRLGQWRPCRKVLPDRSRAARDKANQKLVEYIVKAKGAESHLRAILHSRKPSRWLKTFLSSNQYVTCMETYLEDEAQLDEVVEYLQGVCRDMDGEMPARGSGDRIRFILDVLLPEAIICAISAVEAVDYKTAEQKYLRGPTLSYREKEIFDNELLEERNRRRR
uniprot
proteins
function
FUNCTION: Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
77974
uniprot
proteins
protein_family
PWWP3A family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
698
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Recruited to DNA damage sites via its interaction with the BRCT domain of TP53BP1. {ECO:0000250}.
uniprot
proteins