Slc12a5
entrez
57138
canonical
uniprot
Q91V14
canonical
ensembl
ENSMUSG00000017740
resolver
ensp
ENSMUSP00000096690
resolver
ensp
ENSMUSP00000143870
resolver
ensp
ENSMUSP00000144623
resolver
enst
ENSMUST00000202223
resolver
genesymbol
Slc12a5
resolver
genesymbol_syn
Kcc2
resolver
genesymbol_syn
Kiaa1176
resolver
uniprot
A0A076FR46
resolver
uniprot
A0A076FRG6
resolver
uniprot
A0A076FSX1
resolver
uniprot
A0A0J9YTV8
resolver
uniprot
A2A5L0
resolver
uniprot
Q3UHQ2
resolver
uniprot
Q7TQC9
resolver
uniprot
Q80TI5
resolver
uniprot
Q9Z0M7
resolver
uniprot_entry
A0A076FR46_MOUSE
resolver
uniprot_entry
A0A076FRG6_MOUSE
resolver
uniprot_entry
A0A076FSX1_MOUSE
resolver
uniprot_entry
A0A0J9YTV8_MOUSE
resolver
uniprot_entry
S12A5_MOUSE
resolver
uniprot_sec
A2A5L0
resolver
uniprot_sec
Q3UHQ2
resolver
uniprot_sec
Q7TQC9
resolver
uniprot_sec
Q80TI5
resolver
uniprot_sec
Q9Z0M7
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited following phosphorylation by OXSR1/OSR1 and STK39/SPAK: phosphorylation takes place downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4) in response to hyperosmotic stress and subsequent cell shrinkage. {ECO:0000269|PubMed:19665974}.
uniprot
proteins
amino_acid_sequence
MSRRFTVTSLPPAASAASADPESRRHSVADPRRLPREDVKGDGNPKESSPFINSTDTEKGREYDGRNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSREHEEAENNEGGKKKPVQAPRMGTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNGVVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAEDASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKSAFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRLLNATCDEYFTRNNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERRGMPSVGLADGTPVDMDHPYVFSDMTSYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACIEGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDGIVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACAVQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQLKAGKGLTIVGSVLEGTFLDNHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHLIQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGNPERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTTFLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDESRGSIRRKNPANPRLRLNVPEETACDNEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGERETDPEVHLTWTKDKSVAEKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLNEVIVNKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEQLDRVMLVRGGGREVITIYS
uniprot
proteins
function
FUNCTION: Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis (By similarity). As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation (By similarity). {ECO:0000250|UniProtKB:Q63633, ECO:0000250|UniProtKB:Q9H2X9}.
uniprot
proteins
mass_dalton
126271
uniprot
proteins
mutagenesis
MUTAGEN 680..681; /note="LL->AA: Inhibits endocytosis. Abolishes interaction with AP2A1."; /evidence="ECO:0000269|PubMed:18625303"; MUTAGEN 684..685; /note="EE->AA: Decreases endocytosis."; /evidence="ECO:0000269|PubMed:18625303
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Thr-929 and Thr-1029 by OXSR1/OSR1 and STK39/SPAK downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4), inhibiting the potassium-chloride cotransport activity. {ECO:0000269|PubMed:19665974}.
uniprot
proteins
protein_family
K/Cl co-transporter subfamily
uniprot
proteins
protein_family
SLC12A transporter family
uniprot
proteins
pubmed
10077537
uniprot
proteins
pubmed
11395011
uniprot
proteins
pubmed
11471062
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17715129
uniprot
proteins
pubmed
18625303
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19665974
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
33597714
uniprot
proteins
sequence_length
1138
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11395011}; Multi-pass membrane protein {ECO:0000269|PubMed:11395011, ECO:0000269|PubMed:33597714}. Cell projection, dendrite {ECO:0000269|PubMed:11395011}. Note=Detected on dendrites, but not on axons of spinal cord neurons and at GPHN-positive inhibitory synapses. {ECO:0000269|PubMed:11395011}.
uniprot
proteins
transmembrane_region
TRANSMEM 123..143; /note="Discontinuously helical; Name=1"; /evidence="ECO:0000269|PubMed:33597714, ECO:0007744|PDB:7D14"; TRANSMEM 152..176; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:33597714, ECO:0007744|PDB:7D14"; TRANSMEM 198..227; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:33597714, ECO:0007744|PDB:7D14"; TRANSMEM 252..273; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:33597714, ECO:0007744|PDB:7D14"; TRANSMEM 274..299; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:33597714, ECO:0007744|PDB:7D14"; TRANSMEM 423..443; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:33597714, ECO:0007744|PDB:7D14"; TRANSMEM 453..476; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:33597714, ECO:0007744|PDB:7D14"; TRANSMEM 509..537; /note="Helical; Name=8"; /evidence="ECO:0000269|PubMed:33597714, ECO:0007744|PDB:7D14"; TRANSMEM 550..575; /note="Helical; Name=9"; /evidence="ECO:0000269|PubMed:33597714, ECO:0007744|PDB:7D14"; TRANSMEM 576..601; /note="Helical; Name=10"; /evidence="ECO:0000269|PubMed:33597714, ECO:0007744|PDB:7D14"; TRANSMEM 619..636; /note="Helical; Name=11"; /evidence="ECO:0000269|PubMed:33597714, ECO:0007744|PDB:7D14"; TRANSMEM 637..655; /note="Helical; Name=12"; /evidence="ECO:0000269|PubMed:33597714, ECO:0007744|PDB:7D14
uniprot
proteins