Trim65
entrez
338364
canonical
uniprot
Q8BFW4
canonical
ensembl
ENSMUSG00000054517
resolver
ensp
ENSMUSP00000063410
resolver
ensp
ENSMUSP00000102048
resolver
genesymbol
Trim65
resolver
uniprot
A2A867
resolver
uniprot
Q6PGD3
resolver
uniprot
Q8BJT1
resolver
uniprot_entry
Q8BJT1_MOUSE
resolver
uniprot_entry
TRI65_MOUSE
resolver
uniprot_sec
A2A867
resolver
uniprot_sec
Q6PGD3
resolver
amino_acid_sequence
MAAQLLEEDVVTCSICLGRYRDPVTLPCGHSFCGNCIQDSWRSCEKSCPECRQPFPEGAKLSRNVKMSTLLQALPVLPAPPAVTPRRDSATSHSARCLRHGRPLEFFCRTEGLCVCSACTVHDCSHHERALLDVERRVREDQLRARVLVTQQQVAQAETQLQELQEQRSRIESSACTLASVVSRRFSSLLQALEKQQASTLSDIEVAKKQALGQVLNEKQRLTDHLRALSQYDQSVQDLLAQADDCIFFQELQQLPEPTESLGPLTSPQWNEEQQLSNVNQLLSPLCELLLEEKSLPKVAAKAADAGPLETLGPLAPVPSAVCPLRKKLWQNYRNLTFDPETANQYLHLSHKDQRVTHHFQAQGPAKSGSFELWQVQCTQSFQTGQHYWEVRVSDHSVTLGVTYPKLSRQKLGTHTDNIGRGPCSWGLCIQEDSMQAWHNGKSQRLRGLPGQLLGVDLNLTSGCLTFYSLEPRTQPLHTFYAVFSQPLFPVFWLLEGRTLTLCHQPEATLPARPQEEATAPS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase that plays a role in several processes including innate immnity, autophagy or inflammation (PubMed:31310649, PubMed:34512673). Negatively regulates miRNAs by modulating the ubiquitination and stability of TNRC6A, a protein involved in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs. This ubiquitination results in the suppressed expression of miR-138-5p leading to increased autophagy (By similarity). Upon enteroviral infection, promotes 'Lys-63'-mediated ubiquitination activation of IFIH1/MDA5 leading to innate signaling cascade. Mechanistically, selectively recognizes MDA5 filaments that occur on dsRNAs (By similarity). Also plays a role in limitation of inflammation through different mechanisms. First, promotes 'Lys-48'-mediated ubiquitination of VCAM1 leading to its degradation and limitation of LPS-induced lung inflammation (PubMed:31310649). In addition, negatively regulates inflammasome activation by promoting 'lys48'-linked ubiquitination of NLRP3 which is critical for the inhibition of NLRP3 inflammasome activation in resting macrophages (PubMed:34512673). {ECO:0000250|UniProtKB:Q6PJ69, ECO:0000269|PubMed:31310649, ECO:0000269|PubMed:34512673}.
uniprot
proteins
mass_dalton
58458
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q6PJ69}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31310649
uniprot
proteins
pubmed
34512673
uniprot
proteins
sequence_length
522
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6PJ69}.
uniprot
proteins