IL17A
entrez
3605
canonical
uniprot
Q16552
canonical
ensembl
ENSG00000112115
resolver
ensp
ENSP00000497968
resolver
enst
ENST00000648244
resolver
genesymbol
IL17A
resolver
genesymbol_syn
CTLA8
resolver
genesymbol_syn
IL17
resolver
hgnc
HGNC:5981
resolver
uniprot
Q5T2P0
resolver
uniprot_entry
IL17_HUMAN
resolver
uniprot_sec
Q5T2P0
resolver
amino_acid_sequence
MTPGKTSLVSLLLLLSLEAIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA
uniprot
proteins
function
FUNCTION: Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (PubMed:24120361). Signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:17911633, PubMed:18684971, PubMed:19825828, PubMed:21350122, PubMed:24120361, PubMed:8676080). Plays an important role in connecting T cell-mediated adaptive immunity and acute inflammatory response to destroy extracellular bacteria and fungi. As a signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites (By similarity). In airway epithelium, mediates neutrophil chemotaxis via induction of CXCL1 and CXCL5 chemokines (By similarity). In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (By similarity). Effector cytokine of a subset of gamma-delta T cells that functions as part of an inflammatory circuit downstream IL1B, TLR2 and IL23A-IL12B to promote neutrophil recruitment for efficient bacterial clearance (By similarity). Effector cytokine of innate immune cells including invariant natural killer cell (iNKT) and group 3 innate lymphoid cells that mediate initial neutrophilic inflammation (By similarity). Involved in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection (PubMed:21350122). Upon acute injury, has a direct role in epithelial barrier formation by regulating OCLN localization and tight junction biogenesis (By similarity). As part of the mucosal immune response induced by commensal bacteria, enhances host's ability to resist pathogenic bacterial and fungal infections by promoting neutrophil recruitment and antimicrobial peptides release (By similarity). In synergy with IL17F, mediates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). Involved in antiviral host defense through various mechanisms (By similarity). Enhances immunity against West Nile virus by promoting T cell cytotoxicity (By similarity). May play a beneficial role in influenza A virus (H5N1) infection by enhancing B cell recruitment and immune response in the lung (By similarity). Contributes to influenza A virus (H1N1) clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (By similarity). {ECO:0000250|UniProtKB:Q62386, ECO:0000269|PubMed:17911633, ECO:0000269|PubMed:18684971, ECO:0000269|PubMed:19825828, ECO:0000269|PubMed:21350122, ECO:0000269|PubMed:24120361, ECO:0000269|PubMed:8676080}.
uniprot
proteins
mass_dalton
17504
uniprot
proteins
mutagenesis
MUTAGEN 69; /note="R->A: Impairs binding to IL17RA and IL17RC."; /evidence="ECO:0000269|PubMed:28827714"; MUTAGEN 78; /note="R->V: Decreases the affinity for IL17RA by 5-fold."; /evidence="ECO:0000269|PubMed:23695682"; MUTAGEN 90; /note="W->V: Has no effect on the affinity for IL17RA."; /evidence="ECO:0000269|PubMed:23695682"; MUTAGEN 108; /note="Y->I: Decreases the affinity for IL17RA."; /evidence="ECO:0000269|PubMed:23695682"; MUTAGEN 109; /note="H->S: Decreases the affinity for IL17RA."; /evidence="ECO:0000269|PubMed:23695682
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. Found both in glycosylated and nonglycosylated forms. {ECO:0000269|PubMed:8676080}.
uniprot
proteins
protein_family
IL-17 family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17355969
uniprot
proteins
pubmed
17763419
uniprot
proteins
pubmed
17911633
uniprot
proteins
pubmed
18684971
uniprot
proteins
pubmed
19825828
uniprot
proteins
pubmed
19835883
uniprot
proteins
pubmed
21350122
uniprot
proteins
pubmed
23695682
uniprot
proteins
pubmed
24120361
uniprot
proteins
pubmed
27795421
uniprot
proteins
pubmed
28827714
uniprot
proteins
pubmed
32187518
uniprot
proteins
pubmed
7499828
uniprot
proteins
pubmed
8676080
uniprot
proteins
sequence_length
155
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17763419, ECO:0000269|PubMed:8676080}.
uniprot
proteins