FCN2
entrez
2220
canonical
uniprot
Q15485
canonical
ensembl
ENSG00000160339
resolver
ensp
ENSP00000291741
resolver
ensp
ENSP00000291744
resolver
genesymbol
FCN2
resolver
genesymbol_syn
FCNL
resolver
hgnc
HGNC:3624
resolver
uniprot
A6NFG7
resolver
uniprot
A8K478
resolver
uniprot
Q6IS69
resolver
uniprot
Q7M4P4
resolver
uniprot
Q9UC57
resolver
uniprot_entry
FCN2_HUMAN
resolver
uniprot_sec
A6NFG7
resolver
uniprot_sec
A8K478
resolver
uniprot_sec
Q6IS69
resolver
uniprot_sec
Q7M4P4
resolver
uniprot_sec
Q9UC57
resolver
amino_acid_sequence
MELDRAVGVLGAATLLLSFLGMAWALQAADTCPEVKMVGLEGSDKLTILRGCPGLPGAPGPKGEAGTNGKRGERGPPGPPGKAGPPGPNGAPGEPQPCLTGPRTCKDLLDRGHFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRVDGSVDFYRDWATYKQGFGSRLGEFWLGNDNIHALTAQGTSELRVDLVDFEDNYQFAKYRSFKVADEAEKYNLVLGAFVEGSAGDSLTFHNNQSFSTKDQDNDLNTGNCAVMFQGAWWYKNCHVSNLNGRYLRGTHGSFANGINWKSGKGYNYSYKVSEMKVRPA
uniprot
proteins
function
FUNCTION: Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:10679061, PubMed:14707097, PubMed:15804047, PubMed:17215869, PubMed:25344472, PubMed:8576206). Specifically recognizes and binds carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway (PubMed:14707097). Specifically binds N-Acetylglucosamine (GlcNAc), as well as phosphocholine and lipoteichoic acid moieties on the surface of pathogens (PubMed:14707097, PubMed:17215869, PubMed:25344472, PubMed:8576206). Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect (PubMed:8576206). {ECO:0000269|PubMed:10679061, ECO:0000269|PubMed:14707097, ECO:0000269|PubMed:15804047, ECO:0000269|PubMed:17215869, ECO:0000269|PubMed:25344472, ECO:0000269|PubMed:8576206}.
uniprot
proteins
mass_dalton
34001
uniprot
proteins
protein_family
Ficolin lectin family
uniprot
proteins
pubmed
10679061
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14707097
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15804047
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17215869
uniprot
proteins
pubmed
23460739
uniprot
proteins
pubmed
25344472
uniprot
proteins
pubmed
7498469
uniprot
proteins
pubmed
8576206
uniprot
proteins
pubmed
8586615
uniprot
proteins
pubmed
8884275
uniprot
proteins
sequence_length
313
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7498469, ECO:0000269|PubMed:8576206}. Cell surface {ECO:0000269|PubMed:25344472}. Note=Specifically binds carbohydrates on the surface of pathogens. {ECO:0000269|PubMed:25344472}.
uniprot
proteins