SLC15A2
entrez
6565
canonical
uniprot
Q16348
canonical
ensembl
ENSG00000163406
resolver
ensp
ENSP00000295605
resolver
ensp
ENSP00000417085
resolver
ensp
ENSP00000557021
resolver
ensp
ENSP00000797510
resolver
genesymbol
SLC15A2
resolver
genesymbol_syn
PEPT2
resolver
hgnc
HGNC:10921
resolver
uniprot
A8K1A5
resolver
uniprot
B4E2A7
resolver
uniprot_entry
S15A2_HUMAN
resolver
uniprot_sec
A8K1A5
resolver
uniprot_sec
B4E2A7
resolver
amino_acid_sequence
MNPFQKNESKETLFSPVSIEEVPPRPPSPPKKPSPTICGSNYPLSIAFIVVNEFCERFSYYGMKAVLILYFLYFLHWNEDTSTSIYHAFSSLCYFTPILGAAIADSWLGKFKTIIYLSLVYVLGHVIKSLGALPILGGQVVHTVLSLIGLSLIALGTGGIKPCVAAFGGDQFEEKHAEERTRYFSVFYLSINAGSLISTFITPMLRGDVQCFGEDCYALAFGVPGLLMVIALVVFAMGSKIYNKPPPEGNIVAQVFKCIWFAISNRFKNRSGDIPKRQHWLDWAAEKYPKQLIMDVKALTRVLFLYIPLPMFWALLDQQGSRWTLQAIRMNRNLGFFVLQPDQMQVLNPLLVLIFIPLFDFVIYRLVSKCGINFSSLRKMAVGMILACLAFAVAAAVEIKINEMAPAQPGPQEVFLQVLNLADDEVKVTVVGNENNSLLIESIKSFQKTPHYSKLHLKTKSQDFHFHLKYHNLSLYTEHSVQEKNWYSLVIREDGNSISSMMVKDTESRTTNGMTTVRFVNTLHKDVNISLSTDTSLNVGEDYGVSAYRTVQRGEYPAVHCRTEDKNFSLNLGLLDFGAAYLFVITNNTNQGLQAWKIEDIPANKMSIAWQLPQYALVTAGEVMFSVTGLEFSYSQAPSSMKSVLQAAWLLTIAVGNIIVLVVAQFSGLVQWAEFILFSCLLLVICLIFSIMGYYYVPVKTEDMRGPADKHIPHIQGNMIKLETKKTKL
uniprot
proteins
function
FUNCTION: Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides (PubMed:16434549, PubMed:18367661, PubMed:7756356). Transports neutral and anionic dipeptides with a proton to peptide stoichiometry of 2:1 or 3:1 (By similarity). In kidney, involved in the absorption of circulating di- and tripeptides from the glomerular filtrate (PubMed:7756356). Can also transport beta-lactam antibiotics, such as the aminocephalosporin cefadroxil, and other antiviral and anticancer drugs (PubMed:16434549). Transports the dipeptide-like aminopeptidase inhibitor bestatin (By similarity). Also able to transport carnosine (PubMed:31073693). Involved in innate immunity by promoting the detection of microbial pathogens by NOD-like receptors (NLRs) (By similarity). Mediates transport of bacterial peptidoglycans across the plasma membrane or, in macrophages, the phagosome membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (PubMed:20406817). {ECO:0000250|UniProtKB:P46029, ECO:0000250|UniProtKB:Q63424, ECO:0000250|UniProtKB:Q9ES07, ECO:0000269|PubMed:16434549, ECO:0000269|PubMed:18367661, ECO:0000269|PubMed:20406817, ECO:0000269|PubMed:31073693, ECO:0000269|PubMed:7756356}.
uniprot
proteins
mass_dalton
81783
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16434549
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
18367661
uniprot
proteins
pubmed
20406817
uniprot
proteins
pubmed
31073693
uniprot
proteins
pubmed
7756356
uniprot
proteins
sequence_length
729
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q63424}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:20406817}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:20406817}; Multi-pass membrane protein {ECO:0000255}. Note=Associated with the cell membrane in resting macrophages and enriched in phagocytic cups and phagosomes after particle internalization. {ECO:0000269|PubMed:20406817}.
uniprot
proteins
transmembrane_region
TRANSMEM 58..78; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 84..104; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 114..134; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 140..160; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 184..204; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 218..238; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 296..316; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 344..364; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 381..401; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 612..632; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 644..664; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 675..695; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins