ARG1
entrez
383
canonical
uniprot
P05089
canonical
ensembl
ENSG00000118520
resolver
ensp
ENSP00000349446
resolver
ensp
ENSP00000357066
resolver
ensp
ENSP00000500160
resolver
enst
ENST00000673427
resolver
genesymbol
ARG1
resolver
hgnc
HGNC:663
resolver
uniprot
A0A5F9ZH78
resolver
uniprot
A6NEA0
resolver
uniprot
Q5JWT5
resolver
uniprot
Q5JWT6
resolver
uniprot
Q8TE72
resolver
uniprot
Q9BS50
resolver
uniprot_entry
A0A5F9ZH78_HUMAN
resolver
uniprot_entry
ARGI1_HUMAN
resolver
uniprot_sec
A6NEA0
resolver
uniprot_sec
Q5JWT5
resolver
uniprot_sec
Q5JWT6
resolver
uniprot_sec
Q8TE72
resolver
uniprot_sec
Q9BS50
resolver
amino_acid_sequence
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK
uniprot
proteins
disease_involvement
DISEASE: Argininemia (ARGIN) [MIM:207800]: A rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, intellectual disability, hypotonia, ataxia and progressive spastic quadriplegia. {ECO:0000269|PubMed:1463019, ECO:0000269|PubMed:22959135, ECO:0000269|PubMed:23859858, ECO:0000269|PubMed:7649538}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.5.3.1
uniprot
proteins
function
FUNCTION: Catalyzes the final step of the urea cycle by hydrolyzing L-arginine into urea, a nitrogenous waste product, and L-ornithine, a precursor to proline and polyamines; the urea cycle occurs primarily in the liver and, to a lesser extent, in the kidneys. {ECO:0000305}.; FUNCTION: Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death, is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion (PubMed:15546957, PubMed:16709924, PubMed:19380772). In group 2 innate lymphoid cells (ILC2s) promotes acute type 2 inflammation in the lung and is involved in optimal ILC2 proliferation but not survival (By similarity). In humans, the immunological role in the monocytic/macrophage/dendritic cell (DC) lineage is unsure. {ECO:0000250|UniProtKB:Q61176, ECO:0000269|PubMed:15546957, ECO:0000269|PubMed:16709924, ECO:0000269|PubMed:19380772}.
uniprot
proteins
mass_dalton
34735
uniprot
proteins
pathway_participation
PATHWAY: Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1. {ECO:0000305|PubMed:16141327}.
uniprot
proteins
protein_family
Arginase family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
1463019
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15546957
uniprot
proteins
pubmed
1598908
uniprot
proteins
pubmed
16141327
uniprot
proteins
pubmed
16709924
uniprot
proteins
pubmed
17469833
uniprot
proteins
pubmed
17562323
uniprot
proteins
pubmed
18802628
uniprot
proteins
pubmed
19380772
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21728378
uniprot
proteins
pubmed
2241902
uniprot
proteins
pubmed
22959135
uniprot
proteins
pubmed
23749634
uniprot
proteins
pubmed
23859858
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27043409
uniprot
proteins
pubmed
28813417
uniprot
proteins
pubmed
3174433
uniprot
proteins
pubmed
3540966
uniprot
proteins
pubmed
7649538
uniprot
proteins
sequence_length
322
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:16141327}. Cytoplasmic granule {ECO:0000269|PubMed:15546957}. Note=Localized in azurophil granules of neutrophils (PubMed:15546957). {ECO:0000269|PubMed:15546957}.
uniprot
proteins