DCST2
entrez
127579
canonical
uniprot
Q5T1A1
canonical
ensembl
ENSG00000163354
resolver
ensp
ENSP00000357409
resolver
ensp
ENSP00000436964
resolver
genesymbol
DCST2
resolver
hgnc
HGNC:26562
resolver
uniprot
Q2M2R2
resolver
uniprot
Q8N810
resolver
uniprot
Q96M03
resolver
uniprot_entry
DCST2_HUMAN
resolver
uniprot_sec
Q2M2R2
resolver
uniprot_sec
Q8N810
resolver
uniprot_sec
Q96M03
resolver
amino_acid_sequence
MPKVMKDVVHPLGGEEPSMARAVVRSVGGFTLGLSLATAYGLLELLVEGHSPWGCLVGTLTLAAFLSLGMGFSRQVRATVLLLLPQAFSRQGRTLLLVAAFGLVLQGPCANTLRNFTRASEAVACGAELALNQTAEVLQRAKQPLVSALNKIKAIARKTKEVADRVRKFFRSIMDGVKHIARALRNVWQWLLHIGDVCNSELGNPYLKCARVFDDAKDSCMMVIPQAYHLCYVLMPFKLALCGLASLVQVFCVIPKYIQPFLRQTIGTPVIQLLNRVRQEFEFNMTATHHFSVDLNASRSLSQVAMDLHEAVSMKLHRVREALALMGFTTPLLLVLLYLQALFYRYCYLNWDHYDNIYITSRFLRMEAVRSTAGLPTVLPLSAHEARRYIPPGSIFLSQWEKFFYILETFNLIRHLLLVLFLVFLDYAVFWVLDLARHQLQGEIVARSPVLVSLTVEGTGYAGNIYRDLVSAFDVLQQGNISILSRRCLLRPSEPDSTGYIVIGVMYGLCFFITLFGSYVSRLRRVICASYYPSREQERISYLYNVLLSRRTNLLAALHRSVRRRAADQGHRSAFLVLASRCPCLGPFVSHFWLHQAYCLGCGQPQDEGDMENTVSCSTPGCQGLYCLTCFRLLDNTCSVCASPLSYQGDLDLELDSSDEEGPQLWLAAAQRKDPEQAWLLQQQLQEVLGRSLSMESTSESSDLDEEKGPQQRKHGQQPLPEAHQPVSILTSPEPHRPPETSSATKGAPTPASEPSVPLSPPSLPDPSHPPPK
uniprot
proteins
function
FUNCTION: Essential sperm cell-surface protein required for sperm-egg fusion and fertilization. {ECO:0000250|UniProtKB:A0A140LIJ0}.
uniprot
proteins
mass_dalton
86230
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
sequence_length
773
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:A0A140LIJ0}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes in the anterior acrosome before the acrosome reaction and then translocates to the equatorial segment in acrosome-reacted sperm. {ECO:0000250|UniProtKB:A0A140LIJ0}.
uniprot
proteins
transmembrane_region
TRANSMEM 27..47; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 52..72; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 234..254; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 323..343; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 416..436; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 500..520; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins