Kl
entrez
83504
canonical
uniprot
Q9Z2Y9
canonical
ensembl
ENSRNOG00000001092
resolver
ensp
ENSRNOP00000001449
resolver
enst
ENSRNOT00000001449
resolver
genesymbol
Kl
resolver
uniprot_entry
KLOT_RAT
resolver
amino_acid_sequence
MPARAPPRRLPRLLLLRLLSLHLLLLTLRARCLSAEPGQGAQTWARFARPPVPEASGLLHDTFPDGFLWAVGSAAYQTEGGWRQHGKGASIWDTFTHHPRAIPEDSPIVMAPSGAPLPPLPSTGDVASDSYNNVYRDTEGLRELGVTHYRFSISWARVLPNGTAGTPNREGLRYYRRLLERLRELGVQPVVTLYHWDLPQRLQDTYGGWANRALADHFRDYAELCFRHFGGQVKYWITIDNPYVVAWHGYATGRLAPGVRGSSRLGYLVAHNLLLAHAKVWRLYNTSFRPTQGGRVSIALGSHWITPRRMTDYHIRECQKSLDFVLGWFAKPIFIDGDYPKSMKNNLSSLLPDFTESEKRFIRGTADFFALSFGPTLSFQLLDPSMKFRQLESPSLRQLLSWIDLEYNHPQIFIVENGWFVSGTTRRDDAKYMYYLKKFIMESLKAIRLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKELLPKSSALFYQKLIENNGFPPLPENQPLEGTFPCDFAWGVVDNYIQVDPTLSQFTDPNVYLWDVHHSKRLIKVDGVVAKKRKPYCVDFSAIRPQITLLREMRVTHFRFSLDWALILPLGNQTQVNRTVLHFYRCMVSELVHANITPVVALWQPATPHQGLPHALAKHGAWENPHTALAFADYANLCFEELGHWVKFWITINEPNSRNMTYRAGHHLLKAHALAWHLYDDKFRAAQKGKISIALQVDWIEPACPFSQKDKEVAERVLEFDVGWLAEPIFGSGDYPHVMREWLNQKNNFLLPYFTEDEKKLIRGSFDFLALSHYTTILVDWEKEDPIKYNDYLEVQEMTDITWLNSPNQVAVVPWGLRKALNWLRFKYGDLPMFVTANGIDDDPHAEQDSLRMYYIKNYVNEALKAYVLDGINLCGYFAYSLSDRSVPKSGFYRYAANQFEPKPSIKHYRKIIDNNGFLGSGTLGRFCPEEYTVCTGCGFFQTRKSLLAFISFLVFAFVTSLALIYYYSKKGRRRYK
uniprot
proteins
ec_number
3.2.1.31
uniprot
proteins
function
FUNCTION: Exhibits beta-glucuronidase activity in vitro despite lacking canonical catalytic Glu residues of glycosyl hydrolase 1 family enzymes (By similarity). Hydrolyzes steroid beta-D-glucuronides including estradiol-3-beta-D-glucuronide, estrone-3-beta-D-glucuronide and estriol-3-beta-D-glucuronide (By similarity). Essential for the interaction between FGF23 and FGFR1 and for FGF23-mediated regulation of renal vitamin D and phosphate homeostasis (By similarity). {ECO:0000250|UniProtKB:O35082}.; FUNCTION: The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling. {ECO:0000250|UniProtKB:O35082}.
uniprot
proteins
mass_dalton
116800
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:O35082}.; PTM: Proteolytic cleavage of the membrane-bound form releases a soluble extracellular domain, also referred to as the Klotho peptide. {ECO:0000250|UniProtKB:O35082}.
uniprot
proteins
protein_family
Glycosyl hydrolase 1 family
uniprot
proteins
protein_family
Klotho subfamily
uniprot
proteins
pubmed
10631108
uniprot
proteins
pubmed
10892340
uniprot
proteins
pubmed
11967236
uniprot
proteins
pubmed
12965205
uniprot
proteins
pubmed
17992255
uniprot
proteins
pubmed
9731228
uniprot
proteins
pubmed
9791011
uniprot
proteins
sequence_length
1014
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O35082}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O35082}. Apical cell membrane {ECO:0000250|UniProtKB:O35082}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O35082}. Note=Its shedding leads to a soluble peptide. {ECO:0000250|UniProtKB:O35082}.; SUBCELLULAR LOCATION: [Klotho peptide]: Secreted {ECO:0000250|UniProtKB:O35082}.
uniprot
proteins
transmembrane_region
TRANSMEM 984..1004; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins