Pdk3
entrez
236900
canonical
uniprot
Q922H2
canonical
ensembl
ENSMUSG00000035232
resolver
ensp
ENSMUSP00000036604
resolver
enst
ENSMUST00000045748
resolver
genesymbol
Pdk3
resolver
uniprot
Q4FJR4
resolver
uniprot
Q8BTX1
resolver
uniprot_entry
PDK3_MOUSE
resolver
uniprot_entry
Q4FJR4_MOUSE
resolver
uniprot_sec
Q8BTX1
resolver
amino_acid_sequence
MRLFYRLLKQPVPKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLANTMREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPRVLDNFLNVLINIRNRHNDVVPTMAQGVIEYKEKFGFDPFISSNIQYFLDRFYTNRISFRMLINQHTLLFGGDTNPAHPKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFNAKAPNKPIQVVYVPSHLFHMLFELFKNSMRATVELHEDKKEGYPAVKTLVTLGKEDLSIKISDLGGGVPLRKIDRLFNYMYSTAPRPSLEPTRAAPLAGFGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLKALSSESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDASKYKAKQDKIKSNRTF
uniprot
proteins
ec_number
2.7.11.2
uniprot
proteins
function
FUNCTION: Inhibits pyruvate dehydrogenase activity by phosphorylation of the E1 subunit PDHA1, and thereby regulates glucose metabolism and aerobic respiration. Can also phosphorylate PDHA2. Decreases glucose utilization and increases fat metabolism in response to prolonged fasting, and as adaptation to a high-fat diet. Plays a role in glucose homeostasis and in maintaining normal blood glucose levels in function of nutrient levels and under starvation. Plays a role in the generation of reactive oxygen species (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
47923
uniprot
proteins
protein_family
PDK/BCKDK protein kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
415
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}.
uniprot
proteins