Pofut3
entrez
497619
canonical
uniprot
Q5F2L1
canonical
ensembl
ENSRNOG00000050857
resolver
ensp
ENSRNOP00000105756
resolver
ensp
ENSRNOP00000110497
resolver
enst
ENSRNOT00000122546
resolver
genesymbol
Pofut3
resolver
genesymbol_syn
Fut10
resolver
uniprot
A0ABK0LV74
resolver
uniprot
Q5F2N5
resolver
uniprot_entry
A0ABK0LV74_RAT
resolver
uniprot_entry
OFUT3_RAT
resolver
uniprot_sec
Q5F2N5
resolver
amino_acid_sequence
MVRIPRRKLLPSCLCMTATVFLMVTVQVLVELGKFERKKFKNSDLQDGQKDVEGDPKHLNPLPKKDALALSGRNKVDAGSYPIVLWWSPLTGETGRLGQCGADACFFTINRTFQHHPMTKAFLFYGTDFNIDSLPLPRKAHHDWALFHEESPKNNYKLFHKPVITLFNHTATFSRHSDLPLTTQYLESVEVLKSLRYLVPLQSKNNLRQKLAPLVYVQSDCDPPSDRDSYVRELMAYIEVDSYGECLQNKHLPQQLKNPASMDADAFYRVLAQYKFILAFENAVCDDYITEKFWRPLKLGVVPVYYGSPTIADWLPSNRSAILVSEFSHPRELASFIRRLDYDDGLYETYVEWKLKGEISNQRLLTALREREWGVQDINQDNYIDTFECMVCRRVWANRRLQEQGLPPKQWKADVSHLHCPEPTLFAFSSPASPALRGRSLRELWLPSFQQSKKEAQALRWLVDRNQNFSSEEFWALVFKDSF
uniprot
proteins
ec_number
2.4.1.-
uniprot
proteins
ec_number
2.4.1.221
uniprot
proteins
function
FUNCTION: Protein O-fucosyltransferase that specifically catalyzes O-fucosylation of serine or threonine residues in EMI domains of target proteins, such as MMRN1, MMRN2 and EMID1. Attaches fucose through an O-glycosidic linkage. O-fucosylation of EMI domain-containing proteins may be required for facilitating protein folding and secretion. May also show alpha-(1,3)-fucosyltransferase activity toward the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. However, this was tested with a library of synthetic substrates and this activity is unsure in vivo (By similarity). May be involved in biosynthesis of Lewis X-carrying biantennary N-glycans that regulate neuron stem cell self-renewal during brain development (By similarity). {ECO:0000250|UniProtKB:Q5F2L2, ECO:0000250|UniProtKB:Q6P4F1}.
uniprot
proteins
mass_dalton
56025
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:Q6P4F1}.
uniprot
proteins
protein_family
Glycosyltransferase 10 family
uniprot
proteins
sequence_length
483
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6P4F1}; Single-pass type II membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..31; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins