SAXO6
entrez
56890
canonical
uniprot
Q8TC05
canonical
ensembl
ENSG00000111554
resolver
ensp
ENSP00000302537
resolver
ensp
ENSP00000377175
resolver
ensp
ENSP00000391006
resolver
ensp
ENSP00000408694
resolver
ensp
ENSP00000507100
resolver
ensp
ENSP00000560200
resolver
ensp
ENSP00000560201
resolver
enst
ENST00000682720
resolver
genesymbol
SAXO6
resolver
genesymbol_syn
MDM1
resolver
hgnc
HGNC:29917
resolver
uniprot
A0A804HIJ5
resolver
uniprot
B4DM65
resolver
uniprot
E7EPQ3
resolver
uniprot
O43406
resolver
uniprot
Q8WTV9
resolver
uniprot
Q9NR04
resolver
uniprot_entry
A0A804HIJ5_HUMAN
resolver
uniprot_entry
SAXO6_HUMAN
resolver
uniprot_sec
B4DM65
resolver
uniprot_sec
E7EPQ3
resolver
uniprot_sec
O43406
resolver
uniprot_sec
Q8WTV9
resolver
uniprot_sec
Q9NR04
resolver
amino_acid_sequence
MPVRFKGLSEYQRNFLWKKSYLSESCNSSVGRKYPWAGLRSDQLGITKEPSFISKRRVPYHDPQISKSLEWNGAISESNVVASPEPEAPETPKSQEAEQKDVTQERVHSLEASRVPKRTRSHSADSRAEGASDVENNEGVTNHTPVNENVELEHSTKVLSENVDNGLDRLLRKKAGLTVVPSYNALRNSEYQRQFVWKTSKETAPAFAANQVFHNKSQFVPPFKGNSVIHETEYKRNFKGLSPVKEPKLRNDLRENRNLETVSPERKSNKIDDRLKLEAEMELKDLHQPKRKLTPWKHQRLGKVNSEYRAKFLSPAQYLYKAGAWTHVKGNMPNQVKELREKAEFYRKRVQGTHFSRDHLNQILSDSNCCWDVSSTTSSEGTVSSNIRALDLAGDPTSHKTLQKCPSTEPEEKGNIVEEQPQKNTTEKLGVSAPTIPVRRRLAWDTENTSEDVQKQPGEKEEEDDNEEEGDRKTGKQAFMGEQEKLDVREKSKADKMKEGSDSSVSSEKGGRLPTPKLRELGGIQRTHHDLTTPAVGGAVLVSPSKMKPPAPEQRKRMTSQDCLETSKNDFTKKESRAVSLLTSPAAGIKTVDPLPLREDSEDNIHKFAEATLPVSKIPKYPTNPPGQLPSPPHVPSYWHPSRRIQGSLRDPEFQHNVGKARMNNLQLPQHEAFNDEDEDRLSEISARSAASSLRAFQTLARAKKRKENFWGKT
uniprot
proteins
function
FUNCTION: Microtubule-binding protein that negatively regulates centriole duplication. Binds to and stabilizes microtubules (PubMed:26337392). {ECO:0000269|PubMed:26337392}.
uniprot
proteins
mass_dalton
80735
uniprot
proteins
mutagenesis
MUTAGEN 9..15; /note="SEYQRNF->AAAQRNA: Loss of microtubule binding, no loss of centrosomal localization, little effect on microtubule stability, loss of ability to block centriole reduplication and defective blocking of normal centriole duplication; when associated with 189-A--A-195; 232-A--A-238 and 306-A--A-312."; MUTAGEN 189..195; /note="SEYQRQF->AAAQRQA: Loss of microtubule binding, no loss of centrosomal localization, little effect on microtubule stability, loss of ability to block centriole reduplication and defective blocking of normal centriole duplication; when associated with 9-A--A-15; 232-A--A-238 and 306-A--A-312."; MUTAGEN 232..238; /note="TEYKRNF->AAAKRNA: Loss of microtubule binding, no loss of centrosomal localization, little effect on microtubule stability, loss of ability to block centriole reduplication and defective blocking of normal centriole duplication; when associated with 9-A--A-15; 189-A--A-195 and 306-A--A-312."; MUTAGEN 306..312; /note="SEYRAKF->AAARAKA: Loss of microtubule binding, no loss of centrosomal localization, little effect on microtubule stability, loss of ability to block centriole reduplication and defective blocking of normal centriole duplication; when associated with 9-A--A-15; 189-A--A-195 and 232-A--A-238.
uniprot
proteins
protein_family
MDM1/SAXO6 family
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26337392
uniprot
proteins
sequence_length
714
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26337392}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:26337392}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:26337392}. Note=Localizes to the centriole lumen. {ECO:0000269|PubMed:26337392}.
uniprot
proteins