Camkk2
entrez
83506
canonical
uniprot
O88831
canonical
ensembl
ENSRNOG00000001309
resolver
ensp
ENSRNOP00000001774
resolver
ensp
ENSRNOP00000081396
resolver
ensp
ENSRNOP00000093619
resolver
ensp
ENSRNOP00000099222
resolver
enst
ENSRNOT00000097411
resolver
enst
ENSRNOT00000109897
resolver
enst
ENSRNOT00000172213
resolver
genesymbol
Camkk2
resolver
uniprot
A0A8I5ZSP8
resolver
uniprot
A0A8I6GKR3
resolver
uniprot
A0ABK0KX72
resolver
uniprot_entry
A0A8I5ZSP8_RAT
resolver
uniprot_entry
A0A8I6GKR3_RAT
resolver
uniprot_entry
A0ABK0KX72_RAT
resolver
uniprot_entry
KKCC2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by Ca(2+)/calmodulin. Binding of calmodulin may relieve intrasteric autoinhibition. Autophosphorylation does not alter activity or regulation by Ca(2+)/calmodulin. In part, activity is independent on Ca(2+)/calmodulin.
uniprot
proteins
amino_acid_sequence
MSSCVSSQPTSDRAAPQDELGSGGVSRESQKPCEALRGLSSLSIHLGMESFIVVTECEPGRGVDLSLARDQPLEADGQELPLDASEPESRSLLSGGKMSLQERSQGGPASSSSLDMNGRCICPSLSYSPASSPQSSPRMPRRPTVESHHVSITGLQDCVQLNQYTLKDEIGKGSYGVVKLAYNENDNTYYAMKVLSKKKLIRQAGFPRRPPPRGTRPAPGGCIQPRGPIEQVYQEIAILKKLDHPNVVKLVEVLDDPNEDHLYMVFELVNQGPVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDIKPSNLLVGEDGHIKIADFGVSNEFKGSDALLSNTVGTPAFMAPESLSETRKIFSGKALDVWAMGVTLYCFVFGQCPFMDERIMCLHSKIKSQALEFPDQPDIAEDLKDLITRMLDKNPESRIVVPEIKLHPWVTRHGAEPLPSEDENCTLVEVTEEEVENSVKHIPSLATVILVKTMIRKRSFGNPFEGSRREERSLSAPGNLLTKKPTREWEPLSEPKEARQRRQPPGPRASPCGGGGSALVKGGPCVESCGAPAPGSPPRTPPQQPEEAMEPE
uniprot
proteins
ec_number
2.7.11.17
uniprot
proteins
function
FUNCTION: Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade involved in a number of cellular processes. Phosphorylates CAMK1 and CAMK4. Phosphorylates CAMK1D (By similarity). Seems to be involved in hippocampal activation of CREB1 (By similarity). Efficiently phosphorylates 5'-AMP-activated protein kinase (AMPK) trimer, including that consisting of PRKAA1, PRKAB1 and PRKAG1. This phosphorylation is stimulated in response to Ca(2+) signals. May play a role in neurite growth. Isoform 2 may promote neurite elongation, while isoform 1 may promoter neurite branching. {ECO:0000250, ECO:0000269|PubMed:21807092, ECO:0000269|PubMed:21957496, ECO:0000269|PubMed:8631893, ECO:0000269|PubMed:9822657}.
uniprot
proteins
mass_dalton
64446
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKA (By similarity). Each isoform may show a different pattern of phosphorylation (By similarity). Autophosphorylated. {ECO:0000250}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Ser/Thr protein kinase family
uniprot
proteins
pubmed
10651863
uniprot
proteins
pubmed
11264466
uniprot
proteins
pubmed
21807092
uniprot
proteins
pubmed
21957496
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8631893
uniprot
proteins
pubmed
9276695
uniprot
proteins
pubmed
9822657
uniprot
proteins
sequence_length
587
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96RR4}. Cytoplasm {ECO:0000250|UniProtKB:Q96RR4}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q96RR4}. Note=Predominantly nuclear in unstimulated cells, relocalizes into cytoplasm and neurites after forskolin induction. {ECO:0000250|UniProtKB:Q96RR4}.
uniprot
proteins