Terf1
entrez
21749
canonical
uniprot
P70371
canonical
ensembl
ENSMUSG00000025925
resolver
ensp
ENSMUSP00000027057
resolver
ensp
ENSMUSP00000140744
resolver
ensp
ENSMUSP00000338021
resolver
ensp
ENSMUSP00000338024
resolver
enst
ENSMUST00000027057
resolver
enst
ENSMUST00000188371
resolver
genesymbol
Terf1
resolver
genesymbol_syn
Trf1
resolver
uniprot
A0A0A0MQ74
resolver
uniprot
Q3V252
resolver
uniprot
Q9CY71
resolver
uniprot_entry
A0A0A0MQ74_MOUSE
resolver
uniprot_entry
Q3V252_MOUSE
resolver
uniprot_entry
TERF1_MOUSE
resolver
uniprot_sec
Q9CY71
resolver
amino_acid_sequence
MAETVSSAARDAPSREGWTDSDSPEQEEVGDDAELLQCQLQLGTPREMENAELVAEVEAVAAGWMLDFLCLSLCRAFRDGRSEDFRRTRDSAEAIIHGLHRLTAYQLKTVYICQFLTRVASGKALDAQFEVDERITPLESALMIWNSIEKEHDKLHDEIKNLIKIQAVAVCMEIGSFKEAEEVFERIFGDPEFYTPLERKLLKIISQKDVFHSLFQHFSYSCMMEKIQSYVGDVLSEKSSTFLMKAATKVVENEKARTQASKDRPDATNTGMDTEVGLNKEKSVNGQQSTETEPLVDTVSSIRSHKNALSQLKHRRAPSDFSRNEARTGTLQCETTMERNRRTSGRNRLCVSENQPDTDDKSGRRKRQTWLWEEDRILKCGVKKYGEGNWAKILSHYKFNNRTSVMLKDRWRTMKRLKLIS
uniprot
proteins
function
FUNCTION: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and negatively regulates telomere length. Involved in the regulation of the mitotic spindle. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. {ECO:0000269|PubMed:24413433}.
uniprot
proteins
mass_dalton
48224
uniprot
proteins
post_translational_modification
PTM: Phosphorylated preferentially on Ser-219 in an ATM-dependent manner in response to ionizing DNA damage. {ECO:0000250|UniProtKB:P54274}.; PTM: ADP-ribosylation by TNKS1 or TNKS2 diminishes its ability to bind to telomeric DNA. {ECO:0000250|UniProtKB:P54274}.; PTM: Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome. Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) ubiquitin-protein ligase complex, leading to its degradation by the proteasome (By similarity). {ECO:0000250|UniProtKB:P54274}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19487455
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24413433
uniprot
proteins
pubmed
9002672
uniprot
proteins
sequence_length
421
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625}. Chromosome, telomere {ECO:0000250|UniProtKB:P54274}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:P54274}. Note=Colocalizes with telomeric DNA in interphase and prophase cells. Telomeric localization decreases in metaphase, anaphase and telophase. Associates with the mitotic spindle (By similarity). Interacts with TRIOBP isoform 1; mediates TERF1 localization to the centrosome (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P54274}.
uniprot
proteins