Rassf5
entrez
54355
canonical
uniprot
O35141
canonical
ensembl
ENSRNOG00000005342
resolver
ensembl
ENSRNOG00055020392
resolver
ensembl
ENSRNOG00060014938
resolver
ensembl
ENSRNOG00065021167
resolver
ensp
ENSRNOP00000008055
resolver
ensp
ENSRNOP00000070574
resolver
ensp
ENSRNOP00055028288
resolver
ensp
ENSRNOP00060020403
resolver
ensp
ENSRNOP00065029038
resolver
enst
ENSRNOT00000008055
resolver
enst
ENSRNOT00000080035
resolver
enst
ENSRNOT00055034876
resolver
enst
ENSRNOT00060025576
resolver
enst
ENSRNOT00065036003
resolver
genesymbol
Rassf5
resolver
genesymbol_syn
Nore1
resolver
uniprot
A0A0G2JY99
resolver
uniprot_entry
A0A0G2JY99_RAT
resolver
uniprot_entry
RASF5_RAT
resolver
amino_acid_sequence
MASPAIGQRPYPLLLDPEPPRYLQSLGGTEPPPPARPRRCIPTALISASGASEGRGSRRNARGDPEPTPRDCRHARPVRPGLQQRLRRRPGSHRPRDVRSIFEQPQDPRVLAERGEGHRFAELALRGGPGWCDLCGREVLRQALRCANCKFTCHPECRSLIQLDCRQKEGPALDRQSPESTLTPTFNKNVCKAVEETQHPPTIQEIKQKIDSYNSREKHCLGMKLSEDGTYTGFIKVHLKLRRPVTVPAGIRPQSIYDAIKEVNPAATTDKRTSFYLPLDAIKQLHISSSTTVSEVIQGLLKKFMVVDNPQKFALFKRIHKDGQVLFQKLSIADCPLYLRLLAGPDTDVLSFVLKENETGDVEWDAFSIPELQNFLTILEKEEQDKIHQLQKKYNKFRQKLEEALRESQGKPG
uniprot
proteins
function
FUNCTION: Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association with activated RAP1A is required for directional movement of endothelial cells during wound healing. May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
46680
uniprot
proteins
pubmed
12676952
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
413
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Mainly located in the perinuclear region of unstimulated primary T-cells; upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A (By similarity). {ECO:0000250}.
uniprot
proteins