Slc5a6
entrez
170551
canonical
uniprot
O70247
canonical
ensembl
ENSRNOG00000057628
resolver
ensembl
ENSRNOG00055018542
resolver
ensembl
ENSRNOG00060013362
resolver
ensembl
ENSRNOG00065023118
resolver
ensp
ENSRNOP00000075361
resolver
ensp
ENSRNOP00055025463
resolver
ensp
ENSRNOP00060017999
resolver
ensp
ENSRNOP00065032119
resolver
enst
ENSRNOT00000082623
resolver
enst
ENSRNOT00055031528
resolver
enst
ENSRNOT00060022753
resolver
enst
ENSRNOT00065039504
resolver
genesymbol
Slc5a6
resolver
genesymbol_syn
Smvt
resolver
uniprot
B4F760
resolver
uniprot_entry
B4F760_RAT
resolver
uniprot_entry
SC5A6_RAT
resolver
amino_acid_sequence
MTVASTAAPSYTTSDTNRVISTFSVVDYVVFGLLLVLSLVIGLYHACRGWGRHTVGELLMADRKMGCLPVALSLLATFQSAVAILGGPAEIYRFGTQYWFLGCSYFLGLLIPAHIFIPVFYRLHLTSAYEYLELRFNKAVRICGTVTFIFQMVVYMGVALYAPSLALNAVTGFDLWLSVLALGIVCNIYTALGGLKAVIWTDVFQTLIMFLGQLVVIIVGAAKVGGLGHVWAVASQHGLISGIELDPDPFVRHTFWTLAFGGVFMMLSLYGVNQAQVQRYLSSHSEKAAVLSCYAVFPCQQVALCMSCLIGLVMFAYYKKYSMSPQQEQAAPDQLVLYFVMDLLKDMPGLPGLFVACLFSGSLSTISSAFNSLATVTMEDLIQPWFPQLTETRAIMLSRSLAFAYGLVCLGMAYVSSHLGSVLQAALSIFGMVGGPLLGLFCLGMFFPCANPLGAIVGLLTGLTMAFWIGIGSIVSRMSSAAASPPLNGSSSFLPSNLTVATVTTLMPSTLSKPTGLQQFYSLSYLWYSAHNSTTVIAVGLIVSLLTGGMRGRSLNPGTIYPVLPKLLALLPLSCQKRLCWRSHNQDIPVVTNLFPEKMGNGALQDSRDKERMAEDGLVHQPCSPTYIVQETSL
uniprot
proteins
function
FUNCTION: Sodium-dependent multivitamin transporter that mediates the electrogenic transport of pantothenate, biotin, lipoate and iodide (PubMed:9516450). Functions as a Na(+)-coupled substrate symporter where the stoichiometry of Na(+):substrate is 2:1, creating an electrochemical Na(+) gradient used as driving force for substrate uptake. Required for biotin and pantothenate uptake in the intestine across the brush border membrane (By similarity). Plays a role in the maintenance of intestinal mucosa integrity, by providing the gut mucosa with biotin (By similarity). Contributes to the luminal uptake of biotin and pantothenate into the brain across the blood-brain barrier (By similarity). {ECO:0000250|UniProtKB:Q5U4D8, ECO:0000250|UniProtKB:Q9Y289, ECO:0000269|PubMed:9516450}.
uniprot
proteins
mass_dalton
68642
uniprot
proteins
protein_family
Sodium:solute symporter (SSF) (TC 2.A.21) family
uniprot
proteins
pubmed
12620923
uniprot
proteins
pubmed
9516450
uniprot
proteins
sequence_length
634
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9Y289}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q9Y289}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..43; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 65..85; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 100..120; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 142..162; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 175..195; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 207..227; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 255..275; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 295..315; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 350..370; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 403..423; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 427..447; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 455..475; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 526..546; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins