Stoml3
entrez
229277
canonical
uniprot
Q6PE84
canonical
ensembl
ENSMUSG00000027744
resolver
ensp
ENSMUSP00000029307
resolver
enst
ENSMUST00000029307
resolver
genesymbol
Stoml3
resolver
genesymbol_syn
Sro
resolver
uniprot
B2RS16
resolver
uniprot
Q66JM3
resolver
uniprot
Q8K4P4
resolver
uniprot_entry
B2RS16_MOUSE
resolver
uniprot_entry
STML3_MOUSE
resolver
uniprot_sec
Q66JM3
resolver
uniprot_sec
Q8K4P4
resolver
amino_acid_sequence
MDSPEKLEKNNLVGTNKSRLGVCGWILFFLSFLLMLVTFPISVWMCLKIIKEYERAVVFRLGRIQADKAKGPGLILVLPCIDVFVKVDLRTVTCNIPPQEILTRDSVTTQVDGVVYYRIYSAVSAVANVNDVHQATFLLAQTTLRNVLGTQTLSQILSGREEIAHSIQTLLDDATELWGIRVARVEIKDVRIPVQLQRSMAAEAEATREARAKVLAAEGEMNASKSLKSASMVLAESPVALQLRYLQTLTTVATEKNSTIVFPLPMNILEGIGGISYGNNKKVTAKA
uniprot
proteins
function
FUNCTION: Required for the function of many mechanoreceptors. Modulate mechanotransduction channels and acid-sensing ion channels (ASIC) proteins. Potentiates PIEZO1 and PIEZO2 function by increasing their sensitivity to mechanical stimulations. {ECO:0000269|PubMed:24662763}.
uniprot
proteins
mass_dalton
31591
uniprot
proteins
mutagenesis
MUTAGEN 40; /note="P->S: Mis-localization predominantly to the cytoplasmic compartment."; /evidence="ECO:0000269|PubMed:24662763"; MUTAGEN 89..90; /note="LR->EE: Abolishes the activity of STOML3."; /evidence="ECO:0000269|PubMed:24662763"; MUTAGEN 90; /note="R->S: Abolishes STOML3 modulation of mechanosensitive currents."; /evidence="ECO:0000269|PubMed:24662763"; MUTAGEN 190; /note="V->P: Reduced oligomerization. Does not sensitize mechanically gated currents."; /evidence="ECO:0000269|PubMed:24662763
uniprot
proteins
protein_family
Band 7/mec-2 family
uniprot
proteins
pubmed
12122055
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17167420
uniprot
proteins
pubmed
24662763
uniprot
proteins
sequence_length
287
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12122055, ECO:0000269|PubMed:24662763}; Single-pass type III membrane protein {ECO:0000269|PubMed:12122055}. Note=Detected in lipid rafts, in apical dendrites and in olfactory cilia.
uniprot
proteins
transmembrane_region
TRANSMEM 25..45; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins