Clcnka
entrez
79425
canonical
uniprot
Q06393
canonical
ensembl
ENSRNOG00000052368
resolver
ensembl
ENSRNOG00055023434
resolver
ensembl
ENSRNOG00060019218
resolver
ensembl
ENSRNOG00065026000
resolver
ensp
ENSRNOP00000072591
resolver
ensp
ENSRNOP00055032794
resolver
ensp
ENSRNOP00060027574
resolver
ensp
ENSRNOP00065036889
resolver
enst
ENSRNOT00000089184
resolver
enst
ENSRNOT00055040358
resolver
enst
ENSRNOT00060033683
resolver
enst
ENSRNOT00065045004
resolver
genesymbol
Clcnka
resolver
genesymbol_syn
Clcnk1
resolver
uniprot
A0A0G2K3D2
resolver
uniprot
P97709
resolver
uniprot
Q66HN9
resolver
uniprot_entry
A0A0G2K3D2_RAT
resolver
uniprot_entry
CLCKA_RAT
resolver
uniprot_entry
Q66HN9_RAT
resolver
uniprot_sec
P97709
resolver
activity_regulation
ACTIVITY REGULATION: Activated by extracellular Ca(2+) and inhibited by extracellular acidic pH. {ECO:0000269|PubMed:12111250}.
uniprot
proteins
amino_acid_sequence
MEELVGLREGSSGKPVTLQELWGPCPRIRRGVRRGLEWLKERLFRVGEDWHFLVALGVLMALISYAMNFAIGRVVRAHKWLYREVGDGHLLRYLSWTVYPVALLSFSSGFSQSISPFSGGSGLPELKTMLSGVVLEDYLDIKNFGAKVVGLSCTLATGSTIFLGKVGPFVHLSVMISAYLGRVRAKTIGETENKAKEIEMLSAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVWNYWRGFFAATCGAFMFRLLGVFNSEQETITSIYKTRFRVDVPFDLPEIFFFVALGFICGVLSCAYLFCQRTFLRFIKTNRYTSRLLATSKPSYAALVALVLASITYPPGVGRFMASRLSMAEHLHSLFDNNSWALMTRNSSPPWPAEPDPQNLWLEWCHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFIIGAAIGRLLGEALSVAFPEGIVAGREVNPIMPGGYALAGAAAFSGAVTHTISTALLAFELTGQIVHALPVLMAVLAANAISQNCQPSFYDGTIMAKKLPYLPWIRGRQIGSYPVTVEHFMNCNLTTLAKDTPLEEVVKVVTSTEVSQYPLVETRESQTLVGIVERTHLVQALQTQPASWAPGQERFLQDILAGGCPTQPVTLQLSPETSLYQAHSLFERLTLQSLFVTSRGKAVGSVSWAELKKAISTLINPPAPK
uniprot
proteins
function
FUNCTION: Anion-selective channel permeable to small monovalent anions with ion selectivity for chloride > bromide > nitrate > iodide (By similarity). Forms a homodimeric channel where each subunit has its own ion conduction pathway. Conducts double-barreled currents controlled by two types of gates, two fast gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously (PubMed:12111250, PubMed:16849430, PubMed:20538786). Assembles with the regulatory subunit BSND/Barttin for sorting at the basolateral plasma membrane domain. CLCNKA:BSND channels are activated upon membrane hyperpolarization mostly controlled by fast gating (PubMed:12111250, PubMed:16849430, PubMed:20538786). Mediates transepithelial chloride transport from the lumen to interstitial compartment along the thin ascending limb of Henle's loop, contributing to generation of hypertonic medullary interstitium as a countercurrent system to achieve urine concentration (By similarity). Conducts chloride currents in the stria vascularis of the inner ear to establish the endocochlear potential necessary for normal hearing (By similarity). {ECO:0000250|UniProtKB:P51800, ECO:0000250|UniProtKB:Q9WUB7, ECO:0000269|PubMed:12111250, ECO:0000269|PubMed:16849430, ECO:0000269|PubMed:20538786}.
uniprot
proteins
mass_dalton
75569
uniprot
proteins
mutagenesis
MUTAGEN 166; /note="V->E: Inverts the voltage dependence of channel gating, with fast protopore gating upon membrane depolarization and slow common gating upon hyperpolarization; activated upon hyperpolarization when coexpressed with BSND/Barttin."; /evidence="ECO:0000269|PubMed:16849430, ECO:0000269|PubMed:20538786
uniprot
proteins
protein_family
CLCNKA subfamily
uniprot
proteins
protein_family
Chloride channel (TC 2.A.49) family
uniprot
proteins
pubmed
12111250
uniprot
proteins
pubmed
12759757
uniprot
proteins
pubmed
16849430
uniprot
proteins
pubmed
20538786
uniprot
proteins
pubmed
7680033
uniprot
proteins
pubmed
8034678
uniprot
proteins
pubmed
8041726
uniprot
proteins
sequence_length
687
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000250|UniProtKB:Q9WUB7}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 52..72; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 94..114; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 161..181; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 204..224; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 236..256; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 282..302; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 325..345; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 396..416; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 417..437; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 458..478; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 486..506; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins