Ostn
entrez
239790
canonical
uniprot
P61364
canonical
ensembl
ENSMUSG00000052276
resolver
ensp
ENSMUSP00000067539
resolver
ensp
ENSMUSP00000239232
resolver
enst
ENSMUST00000066852
resolver
genesymbol
Ostn
resolver
uniprot
Q149W1
resolver
uniprot_entry
OSTN_MOUSE
resolver
uniprot_sec
Q149W1
resolver
amino_acid_sequence
MLDWRLASTHFILAMIVMLWGSGKAFSVDLASQEFGTASLQSPPTAREEKSATELSAKLLRLDDLVSLENDVFETKKKRSFSGFGSPLDRLSAGSVEHRGKQRKAVDHSKKRFGIPMDRIGRNRLSSSRG
uniprot
proteins
function
FUNCTION: Hormone that acts as a ligand for natriuretic peptide receptor NPR3/NPR-C and promotes bone growth and physical endurance in muscle. Acts as a regulator of osteoblast differentiation and bone growth by binding to natriuretic peptide receptor NPR3/NPR-C, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production (PubMed:14523025, PubMed:17951249). Required to enhance physical endurance: induced following physical exercise in muscle and promotes cGMP production, probably by interacting with NPR3/NPR-C (PubMed:26668395). May act as an autocrine and paracrine factor linked to glucose metabolism in skeletal muscle (PubMed:15044443). {ECO:0000269|PubMed:14523025, ECO:0000269|PubMed:15044443, ECO:0000269|PubMed:17951249, ECO:0000269|PubMed:26668395}.
uniprot
proteins
mass_dalton
14438
uniprot
proteins
mutagenesis
MUTAGEN 76..79; /note="KKKR->A: Abolishes processing of the protein."; /evidence="ECO:0000269|PubMed:14523025, ECO:0000269|PubMed:15044443"; MUTAGEN 76..79; /note="KKKR->AS: Abolishes processing of the protein."; /evidence="ECO:0000269|PubMed:14523025, ECO:0000269|PubMed:15044443
uniprot
proteins
protein_family
Osteocrin family
uniprot
proteins
pubmed
14523025
uniprot
proteins
pubmed
15044443
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17951249
uniprot
proteins
pubmed
26668395
uniprot
proteins
pubmed
27830782
uniprot
proteins
sequence_length
130
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:14523025, ECO:0000269|PubMed:15044443, ECO:0000269|PubMed:26668395}.
uniprot
proteins