Emc7
entrez
73024
canonical
uniprot
Q9EP72
canonical
ensembl
ENSMUSG00000055943
resolver
ensp
ENSMUSP00000068610
resolver
enst
ENSMUST00000069747
resolver
genesymbol
Emc7
resolver
genesymbol_syn
2900064A13Rik
resolver
genesymbol_syn
Orf3
resolver
uniprot
Q14C26
resolver
uniprot_entry
EMC7_MOUSE
resolver
uniprot_entry
Q14C26_MOUSE
resolver
amino_acid_sequence
MAGALWGFFSVLLLLLSGDAHSSEVPGAAAEGPGGSGVGLGDRFKIEGRAVVPGVKPQDWISAARVLVDGEEHVGFLKTDGSFVVHDIPSGSYVVEVISPAYKFDPVRVDITSKGKMRARYVNYIKTSEVVRLPYPLQMKSSGPPSYFIKRESWGWTDFLMNPMVMMMVLPLLIFVLLPKVVNTSDPDMRREMEQSMNMLNSNHELPDVSEFMTRLFSSKSSGKSSSGSSKTGKSGAGKRR
uniprot
proteins
function
FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. {ECO:0000250|UniProtKB:Q9NPA0}.
uniprot
proteins
mass_dalton
26310
uniprot
proteins
protein_family
EMC7 family
uniprot
proteins
pubmed
10873569
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
241
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9NPA0}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9NPA0}.
uniprot
proteins
transmembrane_region
TRANSMEM 159..179; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins