Rhbdl2
entrez
230726
canonical
uniprot
A2AGA4
canonical
ensembl
ENSMUSG00000043333
resolver
ensp
ENSMUSP00000054546
resolver
ensp
ENSMUSP00000101810
resolver
enst
ENSMUST00000053202
resolver
enst
ENSMUST00000106204
resolver
genesymbol
Rhbdl2
resolver
uniprot_entry
RHBL2_MOUSE
resolver
amino_acid_sequence
MAVAHEMEMESVNLNMEREGKEEPEEEKMKGNGEGKDFPRSRKVHRIVSKWMLPEPVRRTYLERANCLPPPLFIILISLAELAVFIYYAVWKPQKQWITLDTGILESPLTYCPEKREEAWRFISYMLVHAGVQHIVGNLLMQIVLGIPLEMVHKGLRVGLVYLAGVLAGSLASSIFDPLKSLVGASGGVYALMGGYFMNVIVNFREMIPAFGIVRLLVIILIVASDMGFALYRRFFVPANGSPVSFAAHIAGGFAGMSIGYTVFSCFDKTLLKDPRFWIAIAAYVACLLFAVFFNIFLSPAN
uniprot
proteins
ec_number
3.4.21.105
uniprot
proteins
function
FUNCTION: Regulator of proteosome activity independent of enzymatic activity (By similarity). Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3 (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q9NX52}.
uniprot
proteins
mass_dalton
33735
uniprot
proteins
mutagenesis
MUTAGEN 185; /note="A->P: Reduces protease activity."; /evidence="ECO:0000269|PubMed:21439629"; MUTAGEN 186; /note="S->A: Abolishes protease activity."; /evidence="ECO:0000269|PubMed:21439629
uniprot
proteins
post_translational_modification
PTM: Proteolytic processing of the proenzyme produces an N- and a C-terminal fragment. The processing is required for activation of the protease (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Peptidase S54 family
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21439629
uniprot
proteins
sequence_length
302
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Rhomboid-related protein 2, C-terminal fragment]: Cell membrane {ECO:0000250|UniProtKB:Q9NX52}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 71..91; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 127..147; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 158..178; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 182..202; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 211..231; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 244..264; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 277..297; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins