Mapk8
entrez
26419
canonical
uniprot
Q91Y86
canonical
ensembl
ENSMUSG00000021936
resolver
ensp
ENSMUSP00000022504
resolver
ensp
ENSMUSP00000107574
resolver
ensp
ENSMUSP00000107575
resolver
ensp
ENSMUSP00000107576
resolver
enst
ENSMUST00000022504
resolver
enst
ENSMUST00000111943
resolver
enst
ENSMUST00000111944
resolver
enst
ENSMUST00000111945
resolver
genesymbol
Mapk8
resolver
genesymbol_syn
Jnk1
resolver
genesymbol_syn
Prkm8
resolver
uniprot
A6P3E4
resolver
uniprot
F6RNZ9
resolver
uniprot
F8WIL5
resolver
uniprot
G3X8U9
resolver
uniprot
Q544A0
resolver
uniprot
Q7TSJ7
resolver
uniprot_entry
A6P3E4_MOUSE
resolver
uniprot_entry
F6RNZ9_MOUSE
resolver
uniprot_entry
F8WIL5_MOUSE
resolver
uniprot_entry
G3X8U9_MOUSE
resolver
uniprot_entry
MK08_MOUSE
resolver
uniprot_entry
Q544A0_MOUSE
resolver
uniprot_entry
Q7TSJ7_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by SERPINB3 (By similarity). Activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. MAP2K4 shows a strong preference for Tyr-185 while MAP2K7 phosphorylates Tyr-183 preferentially. Inhibited by dual specificity phosphatases, such as DUSP1. {ECO:0000250|UniProtKB:P45983, ECO:0000269|PubMed:10811224}.
uniprot
proteins
amino_acid_sequence
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLAQVQQ
uniprot
proteins
ec_number
2.7.11.24
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death (PubMed:28943315, PubMed:9393873). Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptional activity (PubMed:11602244). Phosphorylates the replication licensing factor CDT1, inhibiting the interaction between CDT1 and the histone H4 acetylase HBO1 to replication origins. Loss of this interaction abrogates the acetylation required for replication initiation. Promotes stressed cell apoptosis by phosphorylating key regulatory factors including p53/TP53 and Yes-associates protein YAP1. In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells (PubMed:10811224). Contributes to the survival of erythroid cells by phosphorylating the antagonist of cell death BAD upon EPO stimulation (By similarity). Mediates starvation-induced BCL2 phosphorylation, BCL2 dissociation from BECN1, and thus activation of autophagy (PubMed:36812915). Phosphorylates STMN2 and hence regulates microtubule dynamics, controlling neurite elongation in cortical neurons (PubMed:21297631). In the developing brain, through its cytoplasmic activity on STMN2, negatively regulates the rate of exit from multipolar stage and of radial migration from the ventricular zone (PubMed:21297631). Phosphorylates several other substrates including heat shock factor protein 4 (HSF4), the deacetylase SIRT1, ELK1, or the E3 ligase ITCH. Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates the heat shock transcription factor HSF1, suppressing HSF1-induced transcriptional activity (By similarity). Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteasomal degradation (PubMed:29153991). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (By similarity). In neurons, phosphorylates SYT4 which captures neuronal dense core vesicles at synapses (By similarity). Phosphorylates EIF4ENIF1/4-ET in response to oxidative stress, promoting P-body assembly (By similarity). Phosphorylates SIRT6 in response to oxidative stress, stimulating its mono-ADP-ribosyltransferase activity (By similarity). Phosphorylates NLRP3, promoting assembly of the NLRP3 inflammasome (PubMed:28943315). Phosphorylates ALKBH5 in response to reactive oxygen species (ROS), promoting ALKBH5 sumoylation and inactivation (By similarity). {ECO:0000250|UniProtKB:P45983, ECO:0000250|UniProtKB:P49185, ECO:0000269|PubMed:10811224, ECO:0000269|PubMed:11602244, ECO:0000269|PubMed:19966288, ECO:0000269|PubMed:21297631, ECO:0000269|PubMed:22441692, ECO:0000269|PubMed:28943315, ECO:0000269|PubMed:29153991, ECO:0000269|PubMed:36812915, ECO:0000269|PubMed:9393873}.
uniprot
proteins
mass_dalton
44229
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by TAOK2 (By similarity). Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme (PubMed:11562351). May be phosphorylated at Thr-183 and Tyr-185 by MAP3K1/MEKK1 (PubMed:17761173). Phosphorylated form is more concentrated at synapses than none-phosphorylated (By similarity). {ECO:0000250|UniProtKB:P45983, ECO:0000250|UniProtKB:P49185, ECO:0000269|PubMed:11562351, ECO:0000269|PubMed:17761173}.
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
MAP kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10523642
uniprot
proteins
pubmed
10811224
uniprot
proteins
pubmed
11562351
uniprot
proteins
pubmed
11602244
uniprot
proteins
pubmed
12391307
uniprot
proteins
pubmed
14499478
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
16166642
uniprot
proteins
pubmed
16618812
uniprot
proteins
pubmed
17761173
uniprot
proteins
pubmed
19966288
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21297631
uniprot
proteins
pubmed
22441692
uniprot
proteins
pubmed
23963642
uniprot
proteins
pubmed
27084103
uniprot
proteins
pubmed
28943315
uniprot
proteins
pubmed
29153991
uniprot
proteins
pubmed
36812915
uniprot
proteins
pubmed
9096336
uniprot
proteins
pubmed
9207092
uniprot
proteins
pubmed
9393873
uniprot
proteins
sequence_length
384
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16618812}. Nucleus {ECO:0000269|PubMed:29153991}. Synapse {ECO:0000250|UniProtKB:P49185}. Note=In the cortical neurons, predominantly cytoplasmic and associated with the Golgi apparatus and endosomal fraction. Increased neuronal activity increases phosphorylated form at synapses (By similarity). Colocalizes with POU5F1 in the nucleus (By similarity) (PubMed:29153991). {ECO:0000250|UniProtKB:P49185, ECO:0000269|PubMed:29153991}.
uniprot
proteins