NSMCE1
entrez
197370
canonical
uniprot
Q8WV22
canonical
ensembl
ENSG00000169189
resolver
ensp
ENSP00000355077
resolver
ensp
ENSP00000539158
resolver
ensp
ENSP00000539162
resolver
ensp
ENSP00000539163
resolver
ensp
ENSP00000539164
resolver
ensp
ENSP00000603525
resolver
ensp
ENSP00000631607
resolver
ensp
ENSP00000631608
resolver
enst
ENST00000361439
resolver
enst
ENST00000869099
resolver
enst
ENST00000869103
resolver
enst
ENST00000869104
resolver
enst
ENST00000869105
resolver
enst
ENST00000933466
resolver
enst
ENST00000961549
resolver
genesymbol
NSMCE1
resolver
hgnc
HGNC:29897
resolver
uniprot
D3DWF6
resolver
uniprot
Q9P045
resolver
uniprot
Q9P049
resolver
uniprot_entry
NSE1_HUMAN
resolver
uniprot_sec
D3DWF6
resolver
uniprot_sec
Q9P045
resolver
uniprot_sec
Q9P049
resolver
amino_acid_sequence
MQGSTRRMGVMTDVHRRFLQLLMTHGVLEEWDVKRLQTHCYKVHDRNATVDKLEDFINNINSVLESLYIEIKRGVTEDDGRPIYALVNLATTSISKMATDFAENELDLFRKALELIIDSETGFASSTNILNLVDQLKGKKMRKKEAEQVLQKFVQNKWLIEKEGEFTLHGRAILEMEQYIRETYPDAVKICNICHSLLIQGQSCETCGIRMHLPCVAKYFQSNAEPRCPHCNDYWPHEIPKVFDPEKERESGVLKSNKKSLRSRQH
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair (PubMed:20864041, PubMed:29225034). NSMCE3/MAGEG1 and NSMCE1 ubiquitin ligase are components of SMC5-SMC6 complex and may positively regulate homologous recombination-mediated DNA repair (PubMed:18086888). MAGEF1-NSMCE1 ubiquitin ligase promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors (PubMed:29225034). {ECO:0000269|PubMed:18086888, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:29225034}.
uniprot
proteins
mass_dalton
30855
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. {ECO:0000269|PubMed:18086888}.
uniprot
proteins
protein_family
NSE1 family
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
14701739
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
18086888
uniprot
proteins
pubmed
20864041
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21364888
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
27427983
uniprot
proteins
pubmed
29225034
uniprot
proteins
sequence_length
266
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18086888}. Chromosome, telomere {ECO:0000305|PubMed:18086888}.
uniprot
proteins