RUFY3
entrez
22902
canonical
uniprot
Q7L099
canonical
ensembl
ENSG00000018189
resolver
ensp
ENSP00000226328
resolver
ensp
ENSP00000370394
resolver
ensp
ENSP00000399771
resolver
ensp
ENSP00000425400
resolver
ensp
ENSP00000662627
resolver
ensp
ENSP00000679817
resolver
ensp
ENSP00000772988
resolver
ensp
ENSP00000797802
resolver
genesymbol
RUFY3
resolver
genesymbol_syn
KIAA0871
resolver
hgnc
HGNC:30285
resolver
uniprot
B3KM25
resolver
uniprot
B4DG59
resolver
uniprot
B4DKC2
resolver
uniprot
B4DYW7
resolver
uniprot
D9N163
resolver
uniprot
O94948
resolver
uniprot
Q9UI00
resolver
uniprot_entry
B4DG59_HUMAN
resolver
uniprot_entry
B4DKC2_HUMAN
resolver
uniprot_entry
RUFY3_HUMAN
resolver
uniprot_sec
B3KM25
resolver
uniprot_sec
B4DYW7
resolver
uniprot_sec
D9N163
resolver
uniprot_sec
O94948
resolver
uniprot_sec
Q9UI00
resolver
amino_acid_sequence
MSALTPPTDMPTPTTDKITQAAMETIYLCKFRVSMDGEWLCLRELDDISLTPDPEPTHEDPNYLMANERMNLMNMAKLSIKGLIESALNLGRTLDSDYAPLQQFFVVMEHCLKHGLKAKKTFLGQNKSFWGPLELVEKLVPEAAEITASVKDLPGLKTPVGRGRAWLRLALMQKKLSEYMKALINKKELLSEFYEPNALMMEEEGAIIAGLLVGLNVIDANFCMKGEDLDSQVGVIDFSMYLKDGNSSKGTEGDGQITAILDQKNYVEELNRHLNATVNNLQAKVDALEKSNTKLTEELAVANNRIITLQEEMERVKEESSYILESNRKGPKQDRTAEGQALSEARKHLKEETQLRLDVEKELEMQISMRQEMELAMKMLEKDVCEKQDALVSLRQQLDDLRALKHELAFKLQSSDLGVKQKSELNSRLEEKTNQMAATIKQLEQSEKDLVKQAKTLNSAANKLIPKHH
uniprot
proteins
function
FUNCTION: ARL8 effector that promotes the coupling of endolysosomes to dynein-dynactin for retrograde transport along microtubules. Acts by binding both GTP-bound ARL8 and dynein-dynactin. In nonneuronal cells, promotes concentration of endolysosomes in the juxtanuclear area. In hippocampal neurons, drives retrograde transport of endolysosomes from the axon to the soma (PubMed:35314674). Plays a role in the generation of neuronal polarity formation and axon growth (By similarity). Implicated in the formation of a single axon by developing neurons (By similarity). May inhibit the formation of additional axons by inhibition of PI3K in minor neuronal processes (By similarity). Plays a role in the formation of F-actin-enriched protrusive structures at the cell periphery (PubMed:25766321). Plays a role in cytoskeletal organization by regulating the subcellular localization of FSCN1 and DBN1 at axonal growth cones (By similarity). {ECO:0000250|UniProtKB:Q5FVJ0, ECO:0000250|UniProtKB:Q9D394, ECO:0000269|PubMed:25766321, ECO:0000269|PubMed:35314674}.
uniprot
proteins
mass_dalton
52965
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PAK1 (PubMed:25766321). Isoform 1 is partially phosphorylated (By similarity). {ECO:0000250|UniProtKB:Q5FVJ0, ECO:0000269|PubMed:25766321}.
uniprot
proteins
pubmed
10048485
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
20376209
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25766321
uniprot
proteins
pubmed
35314674
uniprot
proteins
sequence_length
469
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25766321}. Endomembrane system {ECO:0000269|PubMed:20376209}. Cell projection, invadopodium {ECO:0000269|PubMed:25766321}. Perikaryon {ECO:0000250|UniProtKB:Q9D394}. Cell projection {ECO:0000250|UniProtKB:Q9D394}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9D394}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q9D394}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q9D394}. Lysosome {ECO:0000269|PubMed:35314674}. Note=Colocalizes with PAK1, F-actin, myosins and integrins in invadopodia at the cell periphery (PubMed:25766321). Colocalizes with Ras-related Rab-5 proteins in cytoplasmic vesicles (PubMed:20376209). Accumulates in axon growth cones in a F-actin-dependent manner (By similarity). Colocalizes with FSCN1 and F-actin at filipodia and lamellipodia of axonal growth cones (By similarity). Colocalizes with DBN1 and F-actin at transitional domain of the axonal growth cone (By similarity). Recruitment to endolysosomes partially depends upon the presence of ARL8 (PubMed:35314674). {ECO:0000250|UniProtKB:Q5FVJ0, ECO:0000250|UniProtKB:Q9D394, ECO:0000269|PubMed:20376209, ECO:0000269|PubMed:25766321, ECO:0000269|PubMed:35314674}.
uniprot
proteins