Agtrap
entrez
11610
canonical
uniprot
Q9WVK0
canonical
ensembl
ENSMUSG00000029007
resolver
ensp
ENSMUSP00000030865
resolver
enst
ENSMUST00000030865
resolver
genesymbol
Agtrap
resolver
genesymbol_syn
Atrap
resolver
uniprot
B2KFL8
resolver
uniprot
Q3U7X6
resolver
uniprot
Q9D8Z8
resolver
uniprot
Q9D940
resolver
uniprot_entry
ATRAP_MOUSE
resolver
uniprot_sec
B2KFL8
resolver
uniprot_sec
Q3U7X6
resolver
uniprot_sec
Q9D8Z8
resolver
uniprot_sec
Q9D940
resolver
amino_acid_sequence
MELPAVNLKVILLVHWLLTTWGCLVFSSSYAWGNFTILALGVWAVAQRDSIDAIGMFLGGLVATIFLDIIYISIFYSSVATGDTGRFGAGMAILSLLLKPFSCCLVYHMHRERGGELPLRPDFFGPSQEHSAYQTIDSSSDAAADPFASLENKGQAVPRGY
uniprot
proteins
function
FUNCTION: Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Also induces a decrease in angiotensin II-stimulated transcriptional activity. May play a role of negative regulator in cardiomyocyte hypertrophy induced by angiotensin II through an inhibition of p38 mitogen-activated protein kinase pathway. {ECO:0000269|PubMed:10358057, ECO:0000269|PubMed:15757644}.
uniprot
proteins
mass_dalton
17525
uniprot
proteins
pubmed
10358057
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15757644
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
161
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 27..47; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 54..74; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 87..107; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins