MEX3C
entrez
51320
canonical
uniprot
Q5U5Q3
canonical
ensembl
ENSG00000176624
resolver
ensp
ENSP00000385610
resolver
enst
ENST00000406189
resolver
genesymbol
MEX3C
resolver
genesymbol_syn
RKHD2
resolver
genesymbol_syn
RNF194
resolver
hgnc
HGNC:28040
resolver
uniprot
A1L022
resolver
uniprot
Q9NZE3
resolver
uniprot_entry
MEX3C_HUMAN
resolver
uniprot_sec
A1L022
resolver
uniprot_sec
Q9NZE3
resolver
amino_acid_sequence
MPSGSSAALALAAAPAPLPQPPPPPPPPPPPLPPPSGGPELEGDGLLLRERLAALGLDDPSPAEPGAPALRAPAAAAQGQARRAAELSPEERAPPGRPGAPEAAELELEEDEEEGEEAELDGDLLEEEELEEAEEEDRSSLLLLSPPAATASQTQQIPGGSLGSVLLPAARFDAREAAAAAAAAGVLYGGDDAQGMMAAMLSHAYGPGGCGAAAAALNGEQAALLRRKSVNTTECVPVPSSEHVAEIVGRQGCKIKALRAKTNTYIKTPVRGEEPIFVVTGRKEDVAMAKREILSAAEHFSMIRASRNKNGPALGGLSCSPNLPGQTTVQVRVPYRVVGLVVGPKGATIKRIQQQTHTYIVTPSRDKEPVFEVTGMPENVDRAREEIEMHIAMRTGNYIELNEENDFHYNGTDVSFEGGTLGSAWLSSNPVPPSRARMISNYRNDSSSSLGSGSTDSYFGSNRLADFSPTSPFSTGNFWFGDTLPSVGSEDLAVDSPAFDSLPTSAQTIWTPFEPVNPLSGFGSDPSGNMKTQRRGSQPSTPRLSPTFPESIEHPLARRVRSDPPSTGNHVGLPIYIPAFSNGTNSYSSSNGGSTSSSPPESRRKHDCVICFENEVIAALVPCGHNLFCMECANKICEKRTPSCPVCQTAVTQAIQIHS
uniprot
proteins
disease_involvement
DISEASE: Note=Genetic variations in MEX3C may be associated with susceptibility to essential hypertension. {ECO:0000269|PubMed:17015768}.
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation. {ECO:0000269|PubMed:22863774, ECO:0000269|PubMed:23446422}.
uniprot
proteins
mass_dalton
69366
uniprot
proteins
mutagenesis
MUTAGEN 343; /note="G->D: Prevents RNA binding."; /evidence="ECO:0000269|PubMed:17267406
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
17015768
uniprot
proteins
pubmed
17267406
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22863774
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23446422
uniprot
proteins
sequence_length
659
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17267406}. Nucleus {ECO:0000269|PubMed:17267406}. Note=Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. May act as suppressor of replication stress and chromosome missegregation.
uniprot
proteins