Cul9
entrez
78309
canonical
uniprot
Q80TT8
canonical
ensembl
ENSMUSG00000040327
resolver
ensp
ENSMUSP00000138418
resolver
enst
ENSMUST00000182485
resolver
genesymbol
Cul9
resolver
genesymbol_syn
Kiaa0708
resolver
genesymbol_syn
Parc
resolver
uniprot
Q8BKL9
resolver
uniprot
Q8CGC0
resolver
uniprot
Q8R363
resolver
uniprot
S4R1Y1
resolver
uniprot_entry
CUL9_MOUSE
resolver
uniprot_sec
Q8BKL9
resolver
uniprot_sec
Q8CGC0
resolver
uniprot_sec
Q8R363
resolver
uniprot_sec
S4R1Y1
resolver
amino_acid_sequence
MVGERRAGNLLVPLGPRLQAYPEELLRQRPGHDGHPEYLIRWSVLKCSEEGKVSSEEEKTEHLLMWLSAPEVYANCPMLLRERPIPKGPQHEPAGEVGSFPRDPGGLDELAMTEMEADVRALVRRAARQLAEGGTSSLTAAVLHTVHVLSAYASIGPLTGVFRETGALDLLMHMLCNPEPQIRRSAGKMLQALAAHDAGSRAHVLLSLSQHDGIEQHMDFDSRYTLLELFAETTSTEEHCMALEGIHLPQIPGKLLFSLVKRYLCVTSLLDQLNNSPESGAGDQSSPCLTKEKSRAQQELEFSMAVGNLISELVRSMGWARNLSEQGALPPRPSRSIFQPCLSGPPPLLLPTIVTTPRKQGRAFRGRSEFSSRSGYGEYVQQTVQPGMRVRILDDYEEISAGDEGEFQQSNNGVPPVQVFWQSTGRTYWVHWHMLEILGPEEATGDSASAAVEKGAGAAVLGTVCPSWDWKPTHGLYSLPYLQPEPQKNEEESGYLTQAEWWELLFFIKKLDVGEQQPIFQNLHEKLDEEALGEKALGELSVPIEMAEGVLQVLSNRFEGSNLCDLLNSRIYTKYGLLPKELGSLPSSRRHSCSPEPEEGSRSAANFSEKEEACRANAVPPEAEMELASAKTEPPKAQSDSQLFNQLLVTEGMTLPPETQEAATEMARALRGPGPRSSLDQHVAAVLATVQISSLDTNLQLSGLCALSQAVEEVTERDHPLVRPDRPLREKLVKTLVDLLTNQVGEKMVVVMALRLLYLLMTKHEWRPLFAREGGIYAVLICMQEYKTSVLVQQAGLAALKMLAIANSSDVPTFIPSRDSIQPLFDTQMTREIFASIDSATRPGSESLLLSVPAAVVLMLNTEGCSSAVRNGLLLLNLLLCNHHTLGDQIITQELRDTLFRHSGIAPGTEPMPTTRTILTMLLSRYSEPRGSPERAVLETPSTQGQDGSPESLIRSLVGDLSAELFLDLERVLCHEGSPPAAVRPLLRRLQQETQPFLLLLRTLDAPGPNRTLLLTILRVMTRLLDHPETMVLPWHEVLEPCLNCLNGPSSDSEVVQEVTCFLHRLALMQKDYAVVLCCLGGKEALSKVLDKHSTQLLLASELRHLVAECEKYSQLCSNLTSSILAGCIQMVLGQIEDHRRTYKPITIPFFDVFLRHLCQGSSVEVKEDRCWEKVEVSSNPHRASKLTDRNPKTYWESNGSTGSHSITLHMHRGVLIRQLTLLVASEDSSYMPARVVVFGGDNVGCISTELNTVNVMPSASRVTLLENLTRFWPIIQIRIKRCQQGGIDTRVRGVEVLGPKPTFWPLFREQLCRRTCLFYTIRAQAWSRDIAEDRQRLLQLYPRLNRVLRHEQNFADRFLPDDEAAQALGKTCWEALVSPLVQNITSPDAGGVSSLGWLLDQYLEHRESTRSRQGPAASFASQVRRLCHLLVHVEAPPGPSPEPSSQPLSKNSKGQDGSPTPAPTPVCPSTSLRNLTQCWLSVVQGQVSRFLAAAWRASDFVPRYCSLYQRLQSAGSELFGPRAAFTLALRSGFSGALLQQSFLTAAHISEQFARHIDQQIHGGLLGGAAGVGMLGRLQRHLEPIMVLSGLELATTFEHFYQHYMADRLLSLGSSWLEGAVLEQIGPCFPNRLPQLMLQSLHTSEELQHRFHLFQLQQLDRQLLEQGDQEEWRPEKVEEDDEGQETGRELFTDPGPAISVLVLSPRCWPVSPLCYLHHPRKHLQAELCDALERFSSFYSHSQNCPVLDIGPHRRLQWTWLGRAELQFGDQTLHVSTVQMWLLLNFNQSEEVSVETLLRNSDLSPELLHQALLPLTSDNGPLTLEETQDYPQGGVLRLREPRSQTHEEVLWLIPPQTYLSVEKDEGRTLEQKRNLLSCLLVRILKAHREKGLHIDQLVCLVLEAWQKGPDPPGRLGNAAAVGVACSSTDVLSCILHLLGQGYVERRDDRPQVLMYATPEPMGPCRGQADVPFCGNKNTETSRPSPEAVVALASLQLPAGRTMSPQEVEGLMEQTVRQVQETLNLEPDVAQHLLAHSHWGTEQLLQSYSDDPEPLLLAAGLRVPQAQVVPTRPDQCPVCVTPLGPHDDSPSLCCLHCCCKSCWNEYLTTRIEQNFVLNCTCPIADCPAQPTGAFIRNIVSSPEVISKYEKALLRGYVESCSNLTWCTNPQGCDRILCRQGLGSGTTCSKCGWASCFSCSFPEAHYPASCGHMSQWVDDGGYYDGMSVEAQSKHLAKLISKRCPSCQAPIEKNEGCLHMTCARCNHGFCWRCLKSWKPSHKDYYNCSAMVSKAARQEKRFQDYNERCTFHHQAREFAVNLRNQASAIQEVPPPKSFTFLQDACRALEQARKVLAYACVYSFYSQDTEYMDVVEQQTENLELHTNALQILLEETLLRCRDLASSLRFLRADCLSTGTELLRRIQERLLAILQHSTQDFRVGLQSPSVETREVKGSNVPSDQPQGSSGLEVEDEEEEEEEEEEEEEEEEEDVPEWQHEFDEELDNDSFSYDEESENLDRETFFFGDEDEDDESYD
uniprot
proteins
function
FUNCTION: Core component of the Cul9-RING ubiquitin-protein ligase complex composed of CUL9 and RBX1 (By similarity). The CUL9-RBX1 complex mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity and the ubiquitination of BIRC5 (PubMed:24793696). The CUL9-RBX1 complex also mediates mono-ubiquitination of p53/TP53 (By similarity). Acts as a cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and its subsequent function (By similarity). Ubiquitinates apurinic/apyrimidinic endodeoxyribonuclease APEX2 (By similarity). Ubiquitination by the CUL9-RBX1 complex is predominantly mediated by E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2D2 (By similarity). {ECO:0000250|UniProtKB:Q8IWT3, ECO:0000269|PubMed:24793696}.
uniprot
proteins
mass_dalton
282499
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU01426}.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated by the CUL9-RBX1 complex at Lys-87. {ECO:0000250|UniProtKB:Q8IWT3}.; PTM: Neddylated (By similarity). Neddylation is mediated by E1 enzyme UBA3-NAE1 complex and E2 enzyme UBE2F (By similarity). Structural rearrangment of the C-terminal TRIAD/RBR supradomain may play a role in neddylation and deneddylation (By similarity). {ECO:0000250|UniProtKB:Q8IWT3}.
uniprot
proteins
protein_family
Cullin family
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15964813
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21487039
uniprot
proteins
pubmed
24793696
uniprot
proteins
sequence_length
2530
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21487039}.
uniprot
proteins