Sppl2c
entrez
237958
canonical
uniprot
A2A6C4
canonical
ensembl
ENSMUSG00000049506
resolver
ensp
ENSMUSP00000091453
resolver
ensp
ENSMUSP00000102613
resolver
genesymbol
Sppl2c
resolver
genesymbol_syn
Imp5
resolver
uniprot
Q497R4
resolver
uniprot
Q8BHP0
resolver
uniprot_entry
SPP2C_MOUSE
resolver
uniprot_sec
Q497R4
resolver
uniprot_sec
Q8BHP0
resolver
amino_acid_sequence
MACLGSLHPLGSLLLLFLLLLLSPEARGEYGLVRVVSKNWSKDYCVLYSSDYVNLPRDLHHAPLLSLHDGTKTPWCPDEDSFHQAQDSSPRQRPLHQTTTMVTRGNCSFYAKGWLAQDQGAQGLLIVSRARNQQCSDTISKPQDPSKPWPALTIPVAVLRYTDMLDIVSHTYGDTDVRVAMFAPLEPVTDYNMAIIFILAVGTVAAGGYWAGLMEANKLQRRQAQRGGGLGGHNQQQTVAAERSQRAWEDDDFEDAPMDFTPAMTGAVVTMSCSIMILLYFFYDCFVYVMIGIFSLGASTGLYSCLAPILCHLPLWRYQWVLPGQRVSVTWPLLLLAGLCAMVTVLWVIHRNEDHWAWLLQDTLGVAYCLFVLRRVRLPTFKNCTLFLLALLAFDVFFVFITPLFTKTGESIMVEVASGPADSSSHERLPMVLKVPRLSFSALTLCNQPFSILGFGDIVVPGFLVAYCHRFDMQVQSRQVYYMACTVAYAVGLLVTFVAMILMQMGQPALLYLVSSTLLTSLAVATCRQEFTLFWTGQGRAKIPAEPVAQPCIASAVGSKMKLEDAKDSRTTNRFEQAVDGESGDLESSTGDDMAEMVTLSEDEATSPEGHSESSEGWSDTNLDPNELPSGSPMALEAMLIPLIQPIPHPSELGHIRTQSRVHDSSLPWMGLHKRKGLKVKKSMSAQAPL
uniprot
proteins
ec_number
3.4.23.-
uniprot
proteins
function
FUNCTION: Sperm-specific intramembrane-cleaving aspartic protease (I-CLiP) that cleaves distinct tail-anchored proteins and SNARE proteins (PubMed:30733280, PubMed:30733281, PubMed:35960805). In elongated spermatids, modulates intracellular Ca(2+) homeostasis by controlling PLN abundance through proteolytic cleavage (PubMed:30733280). During spermatogenesis, processes SNARE proteins and impacts vesicular trafficking which supports compartmental reorganization in maturating spermatids and may play a role in formation of the acrosome (PubMed:30733281). {ECO:0000269|PubMed:30733280, ECO:0000269|PubMed:30733281, ECO:0000269|PubMed:35960805}.; FUNCTION: In round spermatids, acts as a scaffold protein supporting FREY1 in IZUMO1 recruitment at the endoplasmic reticulum membrane and coordination of IZUMO1 complex assembly. Stabilizes FREY1 at the endoplasmic reticulum membrane through interaction. May recruit IZUMO1 interaction partners. {ECO:0000269|PubMed:35960805}.; FUNCTION: [Isoform 2]: No difference in cleavage specificity compared to isoform 1. {ECO:0000269|PubMed:30733280}.
uniprot
proteins
mass_dalton
76266
uniprot
proteins
mutagenesis
MUTAGEN 106; /note="N->A: Loss of glycosylation."; /evidence="ECO:0000269|PubMed:30733280"; MUTAGEN 395; /note="D->A: Loss of aspartyl protease activity. Reduces interaction with FREY1 and FREY1 protein stability."; /evidence="ECO:0000269|PubMed:35960805"; MUTAGEN 455; /note="F->L: No effect on interaction with FREY1 and FREY1 protein stability."; /evidence="ECO:0000269|PubMed:35960805"; MUTAGEN 457; /note="D->A: Loss of aspartyl protease activity. Reduces interaction with FREY1 and FREY1 protein stability."; /evidence="ECO:0000269|PubMed:35960805"; MUTAGEN 508; /note="P->L: Loss ofaspartyl protease activity. No effect on interaction with FREY."; /evidence="ECO:0000269|PubMed:35960805
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:P49768}.
uniprot
proteins
protein_family
Peptidase A22B family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
30733280
uniprot
proteins
pubmed
30733281
uniprot
proteins
pubmed
35960805
uniprot
proteins
sequence_length
690
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:30733280, ECO:0000269|PubMed:30733281, ECO:0000269|PubMed:35960805}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8IUH8}; Lumenal side {ECO:0000269|PubMed:30733280}.
uniprot
proteins
transmembrane_region
TRANSMEM 193..213; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 261..283; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 285..307; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 329..349; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 355..373; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 385..405; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 449..469; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 483..503; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 505..525; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins