OXGR1
entrez
27199
canonical
uniprot
Q96P68
canonical
ensembl
ENSG00000165621
resolver
ensp
ENSP00000298440
resolver
ensp
ENSP00000437356
resolver
ensp
ENSP00000438800
resolver
ensp
ENSP00000445269
resolver
ensp
ENSP00000545317
resolver
ensp
ENSP00000545318
resolver
ensp
ENSP00000545319
resolver
enst
ENST00000298440
resolver
enst
ENST00000541038
resolver
enst
ENST00000541518
resolver
enst
ENST00000543457
resolver
enst
ENST00000875258
resolver
enst
ENST00000875259
resolver
enst
ENST00000875260
resolver
genesymbol
OXGR1
resolver
genesymbol_syn
GPR80
resolver
genesymbol_syn
GPR99
resolver
genesymbol_syn
P2RY15
resolver
genesymbol_syn
P2Y15
resolver
hgnc
HGNC:4531
resolver
uniprot
Q5T5A7
resolver
uniprot
Q86TL1
resolver
uniprot_entry
OXGR1_HUMAN
resolver
uniprot_sec
Q5T5A7
resolver
uniprot_sec
Q86TL1
resolver
amino_acid_sequence
MNEPLDYLANASDFPDYAAAFGNCTDENIPLKMHYLPVIYGIIFLVGFPGNAVVISTYIFKMRPWKSSTIIMLNLACTDLLYLTSLPFLIHYYASGENWIFGDFMCKFIRFSFHFNLYSSILFLTCFSIFRYCVIIHPMSCFSIHKTRCAVVACAVVWIISLVAVIPMTFLITSTNRTNRSACLDLTSSDELNTIKWYNLILTATTFCLPLVIVTLCYTTIIHTLTHGLQTDSCLKQKARRLTILLLLAFYVCFLPFHILRVIRIESRLLSISCSIENQIHEAYIVSRPLAALNTFGNLLLYVVVSDNFQQAVCSTVRCKVSGNLEQAKKISYSNNP
uniprot
proteins
disease_involvement
DISEASE: Nephrolithiasis, calcium oxalate, 2, with nephrocalcinosis (CAON2) [MIM:620374]: A form of nephrolithiasis, a condition in which urinary supersaturation leads to calcium oxalate stone formation in the urinary system. CAON2 is an autosomal dominant form often resultings in nephrocalcinosis. {ECO:0000269|PubMed:36571463}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for dicarboxylates and amino dicarboxylates, such as alpha-ketoglutarate, itaconate and leukotriene E4 (PubMed:15141213, PubMed:36571463, PubMed:36919698, PubMed:41413034, PubMed:41791372). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C (PubMed:41413034, PubMed:41791372). OXGR1 is coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (PubMed:36919698, PubMed:41413034, PubMed:41791372). Activation by alpha-ketoglutarate produced by proximal tubule renal cells upon metabolic alkalosis initiates an intrarenal paracrine signaling pathway that drives transepithelial salt reabsorption and bicarbonate secretion by SLC26A4/pendrin-positive intercalated cells (By similarity). Also acts as a regulator of vasodilatation in vascular smooth muscle cells: following activation by alpha-ketoglutarate, couples to GNAQ/G(q), initiating a signaling that activates MYLK/MLCK, thereby promoting MYL9 phosphorylation and vascular smooth muscle cell contraction and limiting vasodilation (PubMed:41791372). Receptor for itaconate, a metabolite produced by myeloid lineages (PubMed:36919698). In the respiratory epithelium, couples the binding of itaconate to the activation of GNA11/G(11) and downstream intracellular Ca(2+) release, leading to mucocilliary clearance of airborne pathogens (PubMed:36919698). Receptor for leukotriene E4 (LTE4) produced by mast cells upon allergic inflammation (PubMed:41413034). Binds with high affinity to LTE4 and elicits mucin release from pulmonary epithelium in response to airborne fungi allergens (By similarity). Regulates mucin-producing goblet cell homeostasis (By similarity). {ECO:0000250|UniProtKB:Q6IYF8, ECO:0000269|PubMed:15141213, ECO:0000269|PubMed:36571463, ECO:0000269|PubMed:36919698, ECO:0000269|PubMed:41413034, ECO:0000269|PubMed:41791372}.
uniprot
proteins
mass_dalton
38251
uniprot
proteins
mutagenesis
MUTAGEN 40; /note="Y->A: Decreased activation by alpha-ketoglutarate or itaconate."; /evidence="ECO:0000269|PubMed:41791372"; MUTAGEN 93; /note="Y->F: Decreased activation by alpha-ketoglutarate or itaconate."; /evidence="ECO:0000269|PubMed:41791372"; MUTAGEN 106; /note="C->A: Loss of itaconate-induced intracellular calcium response."; /evidence="ECO:0000269|PubMed:36919698"; MUTAGEN 107; /note="K->A: Slightly decreases itaconate- or alpha-ketoglutarate-induced intracellular calcium response."; /evidence="ECO:0000269|PubMed:36919698"; MUTAGEN 110; /note="R->A: Loss of itaconate-induced receptor endocytosis and intracellular calcium response. Decreased activation by alpha-ketoglutarate or leukotriene E4."; /evidence="ECO:0000269|PubMed:36919698, ECO:0000269|PubMed:41413034, ECO:0000269|PubMed:41791372"; MUTAGEN 114; /note="H->A: Markedly impairs itaconate-, leukotriene E4- or alpha-ketoglutarate-induced intracellular calcium response. Decreased activation by alpha-ketoglutarate."; /evidence="ECO:0000269|PubMed:36919698, ECO:0000269|PubMed:41413034, ECO:0000269|PubMed:41791372"; MUTAGEN 118; /note="Y->F: Markedly impairs itaconate- or alpha-ketoglutarate-induced intracellular calcium response."; /evidence="ECO:0000269|PubMed:36919698"; MUTAGEN 121; /note="I->A: Markedly impairs itaconate- or alpha-ketoglutarate-induced intracellular calcium response."; /evidence="ECO:0000269|PubMed:36919698"; MUTAGEN 258; /note="H->A: Loss of itaconate-induced intracellular calcium response."; /evidence="ECO:0000269|PubMed:36919698"; MUTAGEN 261; /note="R->A: Loss of itaconate-induced receptor endocytosis and intracellular calcium response. Decreased activation by alpha-ketoglutarate or leukotriene E4."; /evidence="ECO:0000269|PubMed:36919698"; MUTAGEN 264; /note="R->A: Slightly decreases itaconate- or alpha-ketoglutarate-induced intracellular calcium response."; /evidence="ECO:0000269|PubMed:36919698"; MUTAGEN 265; /note="I->A: Loss of itaconate-induced intracellular calcium response."; /evidence="ECO:0000269|PubMed:36919698"; MUTAGEN 284; /note="Y->F: Decreased activation by alpha-ketoglutarate, leukotriene E4 or itaconate."; /evidence="ECO:0000269|PubMed:41413034, ECO:0000269|PubMed:41791372"; MUTAGEN 285; /note="I->A: Markedly impairs itaconate- or alpha-ketoglutarate-induced intracellular calcium response."; /evidence="ECO:0000269|PubMed:36919698"; MUTAGEN 288; /note="R->A: Markedly impairs itaconate-, leukotriene E4- or alpha-ketoglutarate-induced intracellular calcium response."; /evidence="ECO:0000269|PubMed:36919698, ECO:0000269|PubMed:41791372
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11574155
uniprot
proteins
pubmed
12044878
uniprot
proteins
pubmed
12098360
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15141213
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
36571463
uniprot
proteins
pubmed
36919698
uniprot
proteins
pubmed
41413034
uniprot
proteins
pubmed
41791372
uniprot
proteins
sequence_length
337
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15141213, ECO:0000269|PubMed:36919698}; Multi-pass membrane protein {ECO:0000269|PubMed:41791372}. Note=Upon itaconate binding, internalizes via endocytosis in a beta-arrestin dependent manner. {ECO:0000269|PubMed:36919698}.
uniprot
proteins
transmembrane_region
TRANSMEM 31..55; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:41413034, ECO:0000269|PubMed:41791372, ECO:0007744|PDB:8YYW, ECO:0007744|PDB:9VMN"; TRANSMEM 70..94; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:41413034, ECO:0000269|PubMed:41791372, ECO:0007744|PDB:8YYW, ECO:0007744|PDB:9VMN"; TRANSMEM 99..127; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:41413034, ECO:0000269|PubMed:41791372, ECO:0007744|PDB:8YYW, ECO:0007744|PDB:9VMN"; TRANSMEM 153..173; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:41413034, ECO:0000269|PubMed:41791372, ECO:0007744|PDB:8YYW, ECO:0007744|PDB:9VMN"; TRANSMEM 191..215; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:41413034, ECO:0000269|PubMed:41791372, ECO:0007744|PDB:8YYW, ECO:0007744|PDB:9VMN"; TRANSMEM 243..266; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:41413034, ECO:0000269|PubMed:41791372, ECO:0007744|PDB:8YYW, ECO:0007744|PDB:9VMN"; TRANSMEM 279..303; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:41413034, ECO:0000269|PubMed:41791372, ECO:0007744|PDB:8YYW, ECO:0007744|PDB:9VMN
uniprot
proteins