RNASE3
entrez
6037
canonical
uniprot
P12724
canonical
ensembl
ENSG00000169397
resolver
ensp
ENSP00000302324
resolver
enst
ENST00000304639
resolver
genesymbol
RNASE3
resolver
genesymbol_syn
ECP
resolver
genesymbol_syn
RNS3
resolver
hgnc
HGNC:10046
resolver
uniprot
Q4VBC1
resolver
uniprot
Q8WTP7
resolver
uniprot
Q8WZ62
resolver
uniprot
Q9GZN9
resolver
uniprot_entry
ECP_HUMAN
resolver
uniprot_sec
Q4VBC1
resolver
uniprot_sec
Q8WTP7
resolver
uniprot_sec
Q8WZ62
resolver
uniprot_sec
Q9GZN9
resolver
amino_acid_sequence
MVPKLFTSQICLLLLLGLMGVEGSLHARPPQFTRAQWFAIQHISLNPPRCTIAMRAINNYRWRCKNQNTFLRTTFANVVNVCGNQSIRCPHNRTLNNCHRSRFRVPLLHCDLINPGAQNISNCTYADRPGRRFYVVACDNRDPRDSPRYPVVPVHLDTTI
uniprot
proteins
ec_number
3.1.27.-
uniprot
proteins
function
FUNCTION: Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content. {ECO:0000269|PubMed:19450231, ECO:0000269|PubMed:2501794}.
uniprot
proteins
mass_dalton
18385
uniprot
proteins
mutagenesis
MUTAGEN 40; /note="I->A: Loss of in vitro formation of amyloid-like aggregates."; /evidence="ECO:0000269|PubMed:20690710
uniprot
proteins
protein_family
Pancreatic ribonuclease family
uniprot
proteins
pubmed
10606511
uniprot
proteins
pubmed
10903870
uniprot
proteins
pubmed
11102386
uniprot
proteins
pubmed
12356310
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18694936
uniprot
proteins
pubmed
19450231
uniprot
proteins
pubmed
20690710
uniprot
proteins
pubmed
2387583
uniprot
proteins
pubmed
2473157
uniprot
proteins
pubmed
2501794
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
2745977
uniprot
proteins
pubmed
3458170
uniprot
proteins
sequence_length
160
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted. Note=Located in the matrix of eosinophil large specific granule, which are released following activation by an immune stimulus.
uniprot
proteins