Fbxl13
entrez
320118
canonical
uniprot
Q8CDU4
canonical
ensembl
ENSMUSG00000048520
resolver
ensp
ENSMUSP00000052716
resolver
ensp
ENSMUSP00000348850
resolver
genesymbol
Fbxl13
resolver
genesymbol_syn
Drc6
resolver
uniprot
B7ZNK1
resolver
uniprot
B7ZNK2
resolver
uniprot
Q8CDE9
resolver
uniprot_entry
B7ZNK1_MOUSE
resolver
uniprot_entry
B7ZNK2_MOUSE
resolver
uniprot_entry
FXL13_MOUSE
resolver
uniprot_sec
Q8CDE9
resolver
amino_acid_sequence
MASLRSATPRLRSYFRDKYIPQICEALLCGLLVTCPEDPLKYLEHMILAIIKRGLENLLWDTCIHPSLKSRVRRLSETYLDELFGLDDQLVTPELMIKACTFYTGHLVKTHFSGWKKVAIPRANQEEIMAEKMDKAIAHDNFRCQKYIFNRWFAYTVMSRERLITTLLRLRHLFYMQRQRIILAKWKERARHKSKTREDDLISKHELQLKKWKFKLGKPISLEGSLSDIAVENRRIAFDISVLPEQAILQIFLYLTFKDMMACSRVNRSWMAMIQRGSLWNSIDFSTVKNIADKCVVTTLQKWRLNVLRLNFRGCDFRTKTLKAVSHCKNLQELNVSDCQSFTDESMRHISEGCPGVLYLNLSNTTITNRTMRLLPRYFHNLQNLSLAYCRKFTDKGLQYLNLGNGCHKLIYLDLSGCTQVLVEKCPRISSVVLIGSPHISDSAFKALSSCDLKKIRFEGNKRISDACFKSIDRNYPGINHIYMVDCKGLTDSSLKSLSLLKQLTVLNLTNCIRIGDIGLKHFFDGPASIRLRELNLTNCSLLGDSSVIRLSERCPNLHYLNLRNCEHLTDLAIEYIASMLSLISVDLSGTLISNEGMTILSRHRKLREVSVSDCVNITDFGIRAYCKTSLLLEHLDVSYCSQLTDDIIKTIAIFCTRITSLNIAGCPKITDAGMEILSARCHYLHILDISGCIQLTDQIIQDLQIGCKQLRILKMQFCKSISPAAAQKMSSVVQHQEYNSDNPPHWFGYDSEGNPLDKIHSRVQLRTYSKLIVKEPFSIDEEDPDSKHQ
uniprot
proteins
function
FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Specifically targets CEP192 isoform 3 for ubiquitin-mediated proteolysis and thereby acts as a regulator of microtubule nucleation activity. {ECO:0000250|UniProtKB:A8JHD7, ECO:0000250|UniProtKB:Q8NEE6}.
uniprot
proteins
mass_dalton
90657
uniprot
proteins
protein_family
DRC6 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
28630322
uniprot
proteins
sequence_length
790
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:A8JHD7}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q8NEE6}.
uniprot
proteins