SNX6
entrez
58533
canonical
uniprot
Q9UNH7
canonical
ensembl
ENSG00000129515
resolver
ensp
ENSP00000355217
resolver
ensp
ENSP00000379779
resolver
ensp
ENSP00000498872
resolver
ensp
ENSP00000652788
resolver
ensp
ENSP00000687658
resolver
enst
ENST00000652385
resolver
genesymbol
SNX6
resolver
hgnc
HGNC:14970
resolver
uniprot
A0A0A0MRI2
resolver
uniprot
C0H5W9
resolver
uniprot
Q9Y449
resolver
uniprot_entry
A0A0A0MRI2_HUMAN
resolver
uniprot_entry
SNX6_HUMAN
resolver
uniprot_sec
C0H5W9
resolver
uniprot_sec
Q9Y449
resolver
amino_acid_sequence
MMEGLDDGPDFLSEEDRGLKAINVDLQSDAALQVDISDALSERDKVKFTVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFVENEDYAGYIIPPAPPRPDFDASREKLQKLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRRDLNFHVFLEYNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVKDVDDFFEHERTFLLEYHNRVKDASAKSDRMTRSHKSAADDYNRIGSSLYALGTQDSTDICKFFLKVSELFDKTRKIEARVSADEDLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKARAKNKDVLQAETSQQLCCQKFEKISESAKQELIDFKTRRVAAFRKNLVELAELELKHAKGNLQLLQNCLAVLNGDT
uniprot
proteins
function
FUNCTION: Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex (PubMed:19935774). The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R (PubMed:17148574). May function as link between transport vesicles and dynactin (Probable). Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network (PubMed:20354142). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942). In association with GIT1 involved in EGFR degradation. Promotes lysosomal degradation of CDKN1B (By similarity). May contribute to transcription regulation (Probable). {ECO:0000250|UniProtKB:Q6P8X1, ECO:0000269|PubMed:17148574, ECO:0000269|PubMed:19935774, ECO:0000269|PubMed:20354142, ECO:0000269|PubMed:23085988, ECO:0000269|PubMed:24610942, ECO:0000303|PubMed:19935774, ECO:0000303|PubMed:20830743, ECO:0000305}.
uniprot
proteins
mass_dalton
46649
uniprot
proteins
mutagenesis
MUTAGEN 68; /note="R->A: Reduces interaction with SNX1. Abolishes location at endosome membranes."; /evidence="ECO:0000269|PubMed:19935774"; MUTAGEN 69; /note="Q->A: No effect on subcellular location."; /evidence="ECO:0000269|PubMed:19935774"; MUTAGEN 97; /note="R->A: No effect on subcellular location."; /evidence="ECO:0000269|PubMed:19935774
uniprot
proteins
post_translational_modification
PTM: In vitro phosphorylated by PIM1; not affecting PIM1-dependent nuclear translocation (PubMed:11591366). {ECO:0000269|PubMed:11591366}.
uniprot
proteins
protein_family
Sorting nexin family
uniprot
proteins
pubmed
11279102
uniprot
proteins
pubmed
11485546
uniprot
proteins
pubmed
11591366
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17148574
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19619496
uniprot
proteins
pubmed
19935774
uniprot
proteins
pubmed
20354142
uniprot
proteins
pubmed
20830743
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23085988
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24610942
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
39073202
uniprot
proteins
sequence_length
406
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:11485546, ECO:0000269|PubMed:17148574, ECO:0000269|PubMed:19935774}. Early endosome membrane {ECO:0000269|PubMed:19935774, ECO:0000303|PubMed:11485546}; Peripheral membrane protein {ECO:0000269|PubMed:11485546}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle {ECO:0000269|PubMed:20354142}. Cytoplasm {ECO:0000269|PubMed:20830743}. Nucleus {ECO:0000269|PubMed:11591366, ECO:0000269|PubMed:20830743}. Note=Interaction with SNX1 or SNX2 promotes location at endosome membranes (PubMed:19935774). Only a minor proportion is seen in the nucleus. {ECO:0000269|PubMed:19935774}.
uniprot
proteins