ASB4
entrez
51666
canonical
uniprot
Q9Y574
canonical
ensembl
ENSG00000005981
resolver
ensp
ENSP00000321388
resolver
ensp
ENSP00000397070
resolver
genesymbol
ASB4
resolver
hgnc
HGNC:16009
resolver
uniprot
A4D1H6
resolver
uniprot
O14586
resolver
uniprot
Q14D68
resolver
uniprot
Q8TBT2
resolver
uniprot_entry
ASB4_HUMAN
resolver
uniprot_sec
A4D1H6
resolver
uniprot_sec
O14586
resolver
uniprot_sec
Q14D68
resolver
uniprot_sec
Q8TBT2
resolver
amino_acid_sequence
MDGTTAPVTKSGAAKLVKRNFLEALKSNDFGKLKAILIQRQIDVDTVFEVEDENMVLASYKQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHVACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHLVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAARIYPPQFHKVIQACHSCPKAIEVVVNAYEHIRWNTKWRRAIPDDDLEKYWDFYHSLFTVCCNSPRTLMHLSRCAIRRTLHNRCHRAIPLLSLPLSLKKYLLLEPEGIIY
uniprot
proteins
function
FUNCTION: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism (By similarity). Also acts as a negative regulator of GPS1, a component of the COP9 signalosome (CSN) multiprotein complex, thereby inhibiting the serine phosphorylation of IRS1 (By similarity). Regulates IRS4 levels by directing its degradation via ubiquitination and thereby decreases the downstream signal of IRS4 (PubMed:21955513). Plays a critical role during early vascular development and proper placentation. Mechanistically, negatively regulates the transcriptional regulator inhibitor of DNA binding 2/ID2 expression through polyubiquitination and proteasome dependent degradation (PubMed:24586788). {ECO:0000250|UniProtKB:Q9WV71, ECO:0000269|PubMed:21955513, ECO:0000269|PubMed:24586788}.
uniprot
proteins
mass_dalton
48195
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Hydroxylation at Asn-246 by HIF1AN may provide an oxygen-dependent regulation mechanism for the function of ASB4 in promoting vascular differentiation. {ECO:0000250}.
uniprot
proteins
protein_family
Ankyrin SOCS box (ASB) family
uniprot
proteins
pubmed
11111040
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21955513
uniprot
proteins
pubmed
24586788
uniprot
proteins
sequence_length
426
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9WV71}.
uniprot
proteins