Rnf144a
entrez
108089
canonical
uniprot
Q925F3
canonical
ensembl
ENSMUSG00000020642
resolver
ensp
ENSMUSP00000020971
resolver
ensp
ENSMUSP00000056073
resolver
ensp
ENSMUSP00000272845
resolver
ensp
ENSMUSP00000272846
resolver
ensp
ENSMUSP00000272848
resolver
ensp
ENSMUSP00000272849
resolver
ensp
ENSMUSP00000272850
resolver
ensp
ENSMUSP00000272852
resolver
enst
ENSMUST00000020971
resolver
enst
ENSMUST00000062149
resolver
genesymbol
Rnf144a
resolver
genesymbol_syn
Kiaa0161
resolver
genesymbol_syn
Rnf144
resolver
genesymbol_syn
Ubce7ip4
resolver
genesymbol_syn
Uip4
resolver
uniprot
Q3UZZ0
resolver
uniprot
Q6A0B4
resolver
uniprot_entry
R144A_MOUSE
resolver
uniprot_sec
Q3UZZ0
resolver
uniprot_sec
Q6A0B4
resolver
amino_acid_sequence
MTTARYRPTWDLALDPLVSCKLCLGEYPAEQMTTIAQCQCIFCTLCLKQYVELLIKEGLETAISCPDAACPKQGHLQENEIECMVAAEIMQRYKKLQFEREVLFDPCRTWCPASTCQAVCQLQDIGLQTPQLVQCKACDMEFCSACKARWHPGQGCPETMPITFLPGETSSAFKMEEGDAPIKRCPKCRVYIERDEGCAQMMCKNCKHAFCWYCLESLDDDFLLIHYDKGPCRNKLGHSRASVIWHRTQVVGIFAGFGLLLLVASPFLLLATPFVLCCKCKCSKGDDDPLPT
uniprot
proteins
ec_number
2.3.2.31
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the ubiquitination and degradation of the DNA damage kinase PRKDC during DNA damage. Positively regulates DNA virus or exogenous cytosolic DNA-triggered innate immune response by mediating STING1 ubiquitination and increasing its 'Lys-6'-linked ubiquitination and translocation from the endoplasmic reticulum to the Golgi leading to downstream signaling pathways. Plays a positive role in EGF-dependent cell proliferation by prolonging EGF/EGFR signaling during EGF stimulation through EGFR ubiquitination. Increases ERK activity independently of EGFR signaling by promoting polyubiquitination and subsequent degradation of VRK3 in the cytosol. {ECO:0000250|UniProtKB:P50876}.
uniprot
proteins
mass_dalton
32845
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. {ECO:0000250|UniProtKB:P50876}.
uniprot
proteins
protein_family
RBR family
uniprot
proteins
protein_family
RNF144 subfamily
uniprot
proteins
pubmed
10431818
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
292
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P50876}; Single-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P50876}.
uniprot
proteins
transmembrane_region
TRANSMEM 250..270; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins