CYB561A3
entrez
220002
canonical
uniprot
Q8NBI2
canonical
ensembl
ENSG00000162144
resolver
ensp
ENSP00000294072
resolver
ensp
ENSP00000389745
resolver
ensp
ENSP00000398979
resolver
ensp
ENSP00000554283
resolver
ensp
ENSP00000697742
resolver
enst
ENST00000447532
resolver
genesymbol
CYB561A3
resolver
genesymbol_syn
CYBASC3
resolver
hgnc
HGNC:23014
resolver
uniprot
B3KPU2
resolver
uniprot
B4DLN9
resolver
uniprot
F5H1Q2
resolver
uniprot
J3KQH4
resolver
uniprot
Q6PK96
resolver
uniprot_entry
CYAC3_HUMAN
resolver
uniprot_entry
F5H1Q2_HUMAN
resolver
uniprot_sec
B3KPU2
resolver
uniprot_sec
B4DLN9
resolver
uniprot_sec
J3KQH4
resolver
uniprot_sec
Q6PK96
resolver
amino_acid_sequence
MVSGRFYLSCLLLGSLGSMCILFTIYWMQYWRGGFAWNGSIYMFNWHPVLMVAGMVVFYGGASLVYRLPQSWVGPKLPWKLLHAALHLMAFVLTVVGLVAVFTFHNHGRTANLYSLHSWLGITTVFLFACQWFLGFAVFLLPWASMWLRSLLKPIHVFFGAAILSLSIASVISGINEKLFFSLKNTTRPYHSLPSEAVFANSTGMLVVAFGLLVLYILLASSWKRPEPGILTDRQPLLHDGE
uniprot
proteins
ec_number
7.2.1.3
uniprot
proteins
function
FUNCTION: Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce iron cations Fe(3+) into Fe(2+) in the lumen of the late endosome and lysosome. Reduced iron can then be extruded from the late endosome and lysosome to the cytoplasm by divalent metal-specific transporters. It is therefore most probably involved in endosomal and lysosomal cellular iron homeostasis. {ECO:0000250|UniProtKB:Q6P1H1}.
uniprot
proteins
mass_dalton
27214
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q6P1H1}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17897319
uniprot
proteins
sequence_length
242
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250|UniProtKB:Q6P1H1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q53TN4}. Lysosome membrane {ECO:0000269|PubMed:17897319}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q53TN4}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 46..66; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 84..104; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 120..140; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 155..175; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 203..223; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins