Tesc
entrez
57816
canonical
uniprot
Q9JKL5
canonical
ensembl
ENSMUSG00000029359
resolver
ensp
ENSMUSP00000031304
resolver
enst
ENSMUST00000031304
resolver
genesymbol
Tesc
resolver
genesymbol_syn
Chp3
resolver
uniprot
D0EM45
resolver
uniprot
Q32Q85
resolver
uniprot
Q8VCN1
resolver
uniprot_entry
CHP3_MOUSE
resolver
uniprot_entry
D0EM45_MOUSE
resolver
uniprot_sec
Q32Q85
resolver
uniprot_sec
Q8VCN1
resolver
amino_acid_sequence
MGAAHSASEEVRELEGKTGFSSDQIEQLHRRFKQLSGDQPTIRKENFNNVPDLELNPIRSKIVRAFFDNRNLRKGSSGLADEINFEDFLTIMSYFRPIDTTLGEEQVELSRKEKLKFLFHMYDSDSDGRITLEEYRNVVEELLSGNPHIEKESARSIADGAMMEAASVCVGQMEPDQVYEGITFEDFLKIWQGIDIETKMHIRFLNMETIALCH
uniprot
proteins
function
FUNCTION: Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin. {ECO:0000269|PubMed:14661968}.
uniprot
proteins
mass_dalton
24600
uniprot
proteins
mutagenesis
MUTAGEN 123; /note="D->A: Abolishes calcium-binding. Does not alter subcellular localization and does not prevent inhibition of calcineurin activity."; /evidence="ECO:0000269|PubMed:14661968
uniprot
proteins
protein_family
CHP subfamily
uniprot
proteins
protein_family
Calcineurin regulatory subunit family
uniprot
proteins
pubmed
11145610
uniprot
proteins
pubmed
14661968
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17717601
uniprot
proteins
pubmed
19345287
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22285131
uniprot
proteins
sequence_length
214
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14661968}. Cytoplasm {ECO:0000269|PubMed:14661968}. Membrane {ECO:0000250|UniProtKB:Q96BS2}; Lipid-anchor {ECO:0000250|UniProtKB:Q96BS2}. Cell membrane {ECO:0000250|UniProtKB:Q96BS2}. Cell projection, lamellipodium {ECO:0000269|PubMed:14661968}. Cell projection, ruffle membrane {ECO:0000269|PubMed:14661968}. Note=Colocalizes with SLC9A1 at the cell membrane. {ECO:0000250|UniProtKB:Q96BS2}.
uniprot
proteins