Fbxo9
entrez
300849
canonical
uniprot
Q5U2X1
canonical
ensembl
ENSRNOG00000008214
resolver
ensp
ENSRNOP00000010961
resolver
ensp
ENSRNOP00000083528
resolver
ensp
ENSRNOP00000100514
resolver
enst
ENSRNOT00000010961
resolver
enst
ENSRNOT00000104314
resolver
enst
ENSRNOT00000150534
resolver
genesymbol
Fbxo9
resolver
uniprot
A0A8I5ZW08
resolver
uniprot
A0A8L2UIB1
resolver
uniprot
A0ABK0LF86
resolver
uniprot_entry
A0A8I5ZW08_RAT
resolver
uniprot_entry
A0A8L2UIB1_RAT
resolver
uniprot_entry
A0ABK0LF86_RAT
resolver
uniprot_entry
FBX9_RAT
resolver
amino_acid_sequence
MAEAEEDCHSDAVRVGDEGHESPAERDLQAQLQMFRAQWMFELTPGVGSSNVESRPCRAGRSSILKAAADKGRQELAKEEKARELFLKAVEEEQNGALYEAIKFYRRAMQLVPDIEFKITYTRSPDGDGVGSSYIEDNEDASKMADLLSYFQQQLTFQESVLKLCQPELETSQTHISVLPMEVLMYIFRWVVSSDLDLRSLEQLSLVCRGFYICARDPEIWRLACLKVWGRSCMKLVPFSSWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYIRFFPDGHVMMLTTPEEPPSIVPRLRTRNTRTDAILLGHYRLSQDADNQTKVFAVITKKKEEKPLDHKYRYFRRVPVQEADHNFHVGLQLCSSGHQRFNKLIWIHHSCHITYRSTGETAVSAFDIDKMYTPLFFARVRSYTAFSERPL
uniprot
proteins
function
FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1. Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway (By similarity). Also regulates PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q8BK06, ECO:0000250|UniProtKB:Q9UK97}.
uniprot
proteins
mass_dalton
50689
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
435
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UK97}.
uniprot
proteins