Cyp1b1
entrez
25426
canonical
uniprot
Q64678
canonical
ensembl
ENSRNOG00000040287
resolver
ensembl
ENSRNOG00055021714
resolver
ensembl
ENSRNOG00060013460
resolver
ensembl
ENSRNOG00065014791
resolver
ensp
ENSRNOP00000075074
resolver
ensp
ENSRNOP00055030280
resolver
ensp
ENSRNOP00060018165
resolver
ensp
ENSRNOP00065019083
resolver
enst
ENSRNOT00000084171
resolver
enst
ENSRNOT00055037193
resolver
enst
ENSRNOT00060022947
resolver
enst
ENSRNOT00065024451
resolver
genesymbol
Cyp1b1
resolver
uniprot_entry
CP1B1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Enzyme activity is increased by cytochrome b5 (PubMed:23821647). Enzyme activity is increased by liposomes containing anionic phospholipids, phosphatidic acid and cardiolipin. Inhibited by naringenin with an IC(50) of 5 uM (By similarity). {ECO:0000250|UniProtKB:Q16678, ECO:0000269|PubMed:23821647}.
uniprot
proteins
amino_acid_sequence
MATSLSADSPQQLSSLSTQQTILLLLVSVLAIVHLGQWLLRQWRRKPWSSPPGPFPWPLIGNAASVGRASHLYFARLARRYGDVFQIRLGSCPVVVLNGESAIHQALVQQGGVFADRPPFASFRVVSGGRSLAFGHYSERWKERRRAAYGTMRAFSTRHPRSRGLLEGHALGEARELVAVLVRRCAGGACLDPTQPIIVAVANVMSAVCFGCRYNHDDAEFLELLSHNEEFGRTVGAGSLVDVMPWLQLFPNPVRTIFREFEQINRNFSNFVLDKFLRHRESLVPGAAPRDMMDAFILSAEKKATGDPGDSPSGLDLEDVPATITDIFGASQDTLSTALLWLLILFTRYPDVQARVQAELDQVVGRDRLPCMSDQPNLPYVMAFLYESMRFTSFLPVTLPHATTANTFVLGYYIPKNTVVFVNQWSVNHDPAKWSNPEDFDPARFLDKDGFINKALASSVMIFSVGKRRCIGEELSKTLLFLFISILAHQCNFKANQNEPSNMSFSYGLSIKPKSFKIHVSLRESMKLLDSAVEKLQAEEACQ
uniprot
proteins
ec_number
1.14.14.1
uniprot
proteins
ec_number
4.2.1.152
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (By similarity). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (By similarity). Exhibits catalytic activity for the formation of hydroxyestrogens from 17beta-estradiol (E2), namely 2- and 4-hydroxy E2 (PubMed:23821647). Metabolizes testosterone and progesterone to B or D ring hydroxylated metabolites (By similarity). May act as a major enzyme for all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (By similarity). Catalyzes the epoxidation of double bonds of certain PUFA. Converts arachidonic acid toward epoxyeicosatrienoic acid (EpETrE) regioisomers, 8,9-, 11,12-, and 14,15- EpETrE, that function as lipid mediators in the vascular system (PubMed:20972997). Additionally, displays dehydratase activity toward oxygenated eicosanoids including hydroperoxyeicosatetraenoates (HpETEs). This activity is independent of cytochrome P450 reductase, NADPH, and O2 (By similarity). Also involved in the oxidative metabolism of xenobiotics, particularly converting polycyclic aromatic hydrocarbons and heterocyclic aryl amines procarcinogens to DNA-damaging products (By similarity). Plays an important role in retinal vascular development. Under ambient/hyperoxic O2 conditions, promotes angiogenesis and capillary morphogenesis of retinal endothelial cells and pericytes, likely by metabolizing the oxygenated products symptomatic of oxidative stress (By similarity). Also, contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression (By similarity). {ECO:0000250|UniProtKB:Q16678, ECO:0000250|UniProtKB:Q64429, ECO:0000269|PubMed:20972997, ECO:0000269|PubMed:23821647}.
uniprot
proteins
mass_dalton
60557
uniprot
proteins
mutagenesis
MUTAGEN 395; /note="L->V: Shifts the 4OHE2:2OHE2 hydroxylation ratio from 0.38 to 1.8. Has the 4OH-hydroxylation specificity of the human enzyme."; /evidence="ECO:0000269|PubMed:23821647
uniprot
proteins
pathway_participation
PATHWAY: Steroid hormone biosynthesis. {ECO:0000250|UniProtKB:Q16678}.; PATHWAY: Cofactor metabolism; retinol metabolism. {ECO:0000250|UniProtKB:Q16678}.; PATHWAY: Lipid metabolism; arachidonate metabolism. {ECO:0000250|UniProtKB:Q16678}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
20972997
uniprot
proteins
pubmed
21785971
uniprot
proteins
pubmed
21867498
uniprot
proteins
pubmed
23026235
uniprot
proteins
pubmed
23821647
uniprot
proteins
pubmed
7744798
uniprot
proteins
pubmed
7788849
uniprot
proteins
sequence_length
543
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q64429}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q64429}. Microsome membrane {ECO:0000250|UniProtKB:Q64429}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q64429}. Mitochondrion {ECO:0000250|UniProtKB:Q64429}. Note=Located primarily in endoplasmic reticulum. Upon treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), CYP1B1 is also targeted to mitochondria. {ECO:0000250|UniProtKB:Q64429}.
uniprot
proteins