ARID4B
entrez
51742
canonical
uniprot
Q4LE39
canonical
ensembl
ENSG00000054267
resolver
ensp
ENSP00000264183
resolver
ensp
ENSP00000264184
resolver
ensp
ENSP00000355562
resolver
ensp
ENSP00000608194
resolver
ensp
ENSP00000782262
resolver
genesymbol
ARID4B
resolver
genesymbol_syn
BRCAA1
resolver
genesymbol_syn
RBBP1L1
resolver
genesymbol_syn
RBP1L1
resolver
genesymbol_syn
SAP180
resolver
hgnc
HGNC:15550
resolver
uniprot
A1L465
resolver
uniprot
Q3MHV4
resolver
uniprot
Q5HY99
resolver
uniprot
Q5T2C2
resolver
uniprot
Q5T2C3
resolver
uniprot
Q5T2C4
resolver
uniprot
Q5T2C5
resolver
uniprot
Q5T2C6
resolver
uniprot
Q6P600
resolver
uniprot
Q86UX1
resolver
uniprot
Q86WR4
resolver
uniprot
Q9H915
resolver
uniprot
Q9NYU3
resolver
uniprot
Q9NZB6
resolver
uniprot
Q9NZG4
resolver
uniprot
Q9P2W4
resolver
uniprot
Q9UF62
resolver
uniprot
Q9Y6E1
resolver
uniprot_entry
ARI4B_HUMAN
resolver
uniprot_sec
A1L465
resolver
uniprot_sec
Q3MHV4
resolver
uniprot_sec
Q5HY99
resolver
uniprot_sec
Q5T2C2
resolver
uniprot_sec
Q5T2C3
resolver
uniprot_sec
Q5T2C4
resolver
uniprot_sec
Q5T2C5
resolver
uniprot_sec
Q5T2C6
resolver
uniprot_sec
Q6P600
resolver
uniprot_sec
Q86UX1
resolver
uniprot_sec
Q86WR4
resolver
uniprot_sec
Q9H915
resolver
uniprot_sec
Q9NYU3
resolver
uniprot_sec
Q9NZB6
resolver
uniprot_sec
Q9NZG4
resolver
uniprot_sec
Q9P2W4
resolver
uniprot_sec
Q9UF62
resolver
uniprot_sec
Q9Y6E1
resolver
amino_acid_sequence
MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPLKVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETLDQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDEDEDDRKQIDELLGKVVCVDYISLDKKKALWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTAPKPDAVLKQAFEQALEFHKSRTIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIEFQMALPEKVVNKQCKECENVKEIKVKEENETEIKEIKMEEERNIIPREEKPIEDEIERKENIKPSLGSKKNLLESIPTHSDQEKEVNIKKPEDNENLDDKDDDTTRVDESLNIKVEAEEEKAKSGDETNKEEDEDDEEAEEEEEEEEEEEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEVLYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDKDEKYSPKNCKLRRLSKPPFQTNPSPEMVSKLDLTDAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERGAQDMDNNGKEESKIDHLTNNRNDLISKEEQNSSSLLEENKVHADLVISKPVSKSPERLRKDIEVLSEDTDYEEDEVTKKRKDVKKDTTDKSSKPQIKRGKRRYCNTEECLKTGSPGKKEEKAKNKESLCMENSSNSSSDEDEEETKAKMTPTKKYNGLEEKRKSLRTTGFYSGFSEVAEKRIKLLNNSDERLQNSRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPEEGVAEESLQTVAEEESCSPSVELEKPPPVNVDSKPIEEKTVEVNDRKAEFPSSGSNSVLNTPPTTPESPSSVTVTEGSRQQSSVTVSEPLAPNQEEVRSIKSETDSTIEVDSVAGELQDLQSEGNSSPAGFDASVSSSSSNQPEPEHPEKACTGQKRVKDAQGGGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESITKSQPVKSVSTGMKSHSTKSPARTQSPGKCGKNGDKDPDLKEPSNRLPKVYKWSFQMSDLENMTSAERITILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVECR
uniprot
proteins
function
FUNCTION: Acts as a transcriptional repressor (PubMed:12724404). May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (PubMed:12724404). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (By similarity). {ECO:0000250|UniProtKB:A2CG63, ECO:0000269|PubMed:12724404}.
uniprot
proteins
mass_dalton
147809
uniprot
proteins
pubmed
11481388
uniprot
proteins
pubmed
12724404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15247124
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17043311
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
1312
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355}. Cytoplasm {ECO:0000269|PubMed:11481388, ECO:0000269|PubMed:15247124}. Note=Cytoplasmic in breast cancer cells. {ECO:0000269|PubMed:15247124}.
uniprot
proteins