ATP2A3
entrez
489
canonical
uniprot
Q93084
canonical
ensembl
ENSG00000074370
resolver
ensp
ENSP00000301387
resolver
ensp
ENSP00000312577
resolver
ensp
ENSP00000353072
resolver
ensp
ENSP00000380229
resolver
ensp
ENSP00000380234
resolver
ensp
ENSP00000380236
resolver
genesymbol
ATP2A3
resolver
hgnc
HGNC:813
resolver
uniprot
A8K9K1
resolver
uniprot
A8MZG0
resolver
uniprot
D3DTJ8
resolver
uniprot
O60900
resolver
uniprot
O60901
resolver
uniprot
O75501
resolver
uniprot
O75502
resolver
uniprot
Q16115
resolver
uniprot
Q6JHX1
resolver
uniprot
Q8TEX5
resolver
uniprot
Q8TEX6
resolver
uniprot_entry
A8K9K1_HUMAN
resolver
uniprot_entry
AT2A3_HUMAN
resolver
uniprot_sec
A8MZG0
resolver
uniprot_sec
D3DTJ8
resolver
uniprot_sec
O60900
resolver
uniprot_sec
O60901
resolver
uniprot_sec
O75501
resolver
uniprot_sec
O75502
resolver
uniprot_sec
Q16115
resolver
uniprot_sec
Q6JHX1
resolver
uniprot_sec
Q8TEX5
resolver
uniprot_sec
Q8TEX6
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN) (By similarity). Enhanced by DWORF; DWORF increases activity by displacing sarcolipin (SLN), phospholamban (PLN) and myoregulin (MRLN) (By similarity). {ECO:0000250|UniProtKB:P04191, ECO:0000250|UniProtKB:Q8R429}.
uniprot
proteins
amino_acid_sequence
MEAAHLLPAADVLRHFSVTAEGGLSPAQVTGARERYGPNELPSEEGKSLWELVLEQFEDLLVRILLLAALVSFVLAWFEEGEETTTAFVEPLVIMLILVANAIVGVWQERNAESAIEALKEYEPEMGKVIRSDRKGVQRIRARDIVPGDIVEVAVGDKVPADLRLIEIKSTTLRVDQSILTGESVSVTKHTEAIPDPRAVNQDKKNMLFSGTNITSGKAVGVAVATGLHTELGKIRSQMAAVEPERTPLQRKLDEFGRQLSHAISVICVAVWVINIGHFADPAHGGSWLRGAVYYFKIAVALAVAAIPEGLPAVITTCLALGTRRMARKNAIVRSLPSVETLGCTSVICSDKTGTLTTNQMSVCRMFVVAEADAGSCLLHEFTISGTTYTPEGEVRQGDQPVRCGQFDGLVELATICALCNDSALDYNEAKGVYEKVGEATETALTCLVEKMNVFDTDLQALSRVERAGACNTVIKQLMRKEFTLEFSRDRKSMSVYCTPTRPHPTGQGSKMFVKGAPESVIERCSSVRVGSRTAPLTPTSREQILAKIRDWGSGSDTLRCLALATRDAPPRKEDMELDDCSKFVQYETDLTFVGCVGMLDPPRPEVAACITRCYQAGIRVVMITGDNKGTAVAICRRLGIFGDTEDVAGKAYTGREFDDLSPEQQRQACRTARCFARVEPAHKSRIVENLQSFNEITAMTGDGVNDAPALKKAEIGIAMGSGTAVAKSAAEMVLSDDNFASIVAAVEEGRAIYSNMKQFIRYLISSNVGEVVCIFLTAILGLPEALIPVQLLWVNLVTDGLPATALGFNPPDLDIMEKLPRSPREALISGWLFFRYLAIGVYVGLATVAAATWWFVYDAEGPHINFYQLRNFLKCSEDNPLFAGIDCEVFESRFPTTMALSVLVTIEMCNALNSVSENQSLLRMPPWMNPWLLVAVAMSMALHFLILLVPPLPLIFQVTPLSGRQWVVVLQISLPVILLDEALKYLSRNHMHEEMSQK
uniprot
proteins
ec_number
7.2.2.10
uniprot
proteins
function
FUNCTION: This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports calcium ions from the cytosol into the sarcoplasmic/endoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction. {ECO:0000269|PubMed:11956212, ECO:0000269|PubMed:15028735}.
uniprot
proteins
mass_dalton
109256
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type IIA subfamily
uniprot
proteins
pubmed
11956212
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
15028735
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28890335
uniprot
proteins
pubmed
34513312
uniprot
proteins
pubmed
8288608
uniprot
proteins
pubmed
8809064
uniprot
proteins
pubmed
9593748
uniprot
proteins
pubmed
9843705
uniprot
proteins
sequence_length
999
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:15028735}; Multi-pass membrane protein {ECO:0000269|PubMed:15028735}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15028735}; Multi-pass membrane protein {ECO:0000269|PubMed:15028735}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:15028735}; Multi-pass membrane protein {ECO:0000269|PubMed:15028735}.
uniprot
proteins
transmembrane_region
TRANSMEM 49..69; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P04191"; TRANSMEM 90..110; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P04191"; TRANSMEM 254..273; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P04191"; TRANSMEM 296..313; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P04191"; TRANSMEM 758..777; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P04191"; TRANSMEM 788..808; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P04191"; TRANSMEM 829..851; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P04191"; TRANSMEM 898..917; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P04191"; TRANSMEM 931..949; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:P04191"; TRANSMEM 965..985; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:P04191
uniprot
proteins