Ormdl1
entrez
227102
canonical
uniprot
Q921I0
canonical
ensembl
ENSMUSG00000026097
resolver
ensp
ENSMUSP00000027266
resolver
enst
ENSMUST00000027266
resolver
genesymbol
Ormdl1
resolver
uniprot
Q8BK13
resolver
uniprot_entry
ORML1_MOUSE
resolver
uniprot_sec
Q8BK13
resolver
amino_acid_sequence
MNVGVAHSEVNPNTRVMNSRGMWLTYALGVGLLHIVLLSIPFCSVPVAWTLTNIIHNLGMYVFLHAVKGTPFETPDQGRARLLTHWEQLDYGVQFTSSRKFFTISPIILYFLASFYTKYDPTHFILNTASLLSVLIPKMPQLHGVRIFGINKY
uniprot
proteins
function
FUNCTION: Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels (PubMed:31880535). When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis (By similarity). {ECO:0000250|UniProtKB:Q8N138, ECO:0000269|PubMed:31880535}.
uniprot
proteins
mass_dalton
17355
uniprot
proteins
protein_family
ORM family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
31880535
uniprot
proteins
sequence_length
153
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9P0S3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9P0S3}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 47..67; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 101..121; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 124..140; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins