HCFC1R1
entrez
54985
canonical
uniprot
Q9NWW0
canonical
ensembl
ENSG00000103145
resolver
ensp
ENSP00000248089
resolver
ensp
ENSP00000346708
resolver
ensp
ENSP00000458628
resolver
ensp
ENSP00000458971
resolver
ensp
ENSP00000459178
resolver
ensp
ENSP00000460639
resolver
ensp
ENSP00000544012
resolver
ensp
ENSP00000585485
resolver
ensp
ENSP00000618674
resolver
enst
ENST00000354679
resolver
enst
ENST00000572355
resolver
enst
ENST00000873953
resolver
enst
ENST00000948615
resolver
genesymbol
HCFC1R1
resolver
genesymbol_syn
HPIP
resolver
hgnc
HGNC:21198
resolver
uniprot
D3DUA7
resolver
uniprot
I3L1N5
resolver
uniprot
J3KNY1
resolver
uniprot
Q68EN7
resolver
uniprot_entry
HPIP_HUMAN
resolver
uniprot_entry
I3L1N5_HUMAN
resolver
uniprot_entry
J3KNY1_HUMAN
resolver
uniprot_sec
D3DUA7
resolver
uniprot_sec
Q68EN7
resolver
amino_acid_sequence
MILQQPLQRGPQGGAQRLPRAALGVTWGLDASSPLRGAVPMSTKRRLEEEQEPLRKQFLSEENMATHFSQLSLHNDHPYCSPPMTFSPALPPLRSPCSELLLWRYPGSLIPEALRLLRLGDTPSPPYPATPAGDIMEL
uniprot
proteins
function
FUNCTION: Regulates HCFC1 activity by modulating its subcellular localization. Overexpression of HCFC1R1 leads to accumulation of HCFC1 in the cytoplasm. HCFC1R1-mediated export may provide the pool of cytoplasmic HCFC1 required for import of virion-derived VP16 into the nucleus. {ECO:0000269|PubMed:12235138}.
uniprot
proteins
mass_dalton
15291
uniprot
proteins
mutagenesis
MUTAGEN 76..79; /note="DHPY->AAPA: Loss of interaction with HCFC1."; /evidence="ECO:0000269|PubMed:12235138"; MUTAGEN 117..119; /note="LRL->ARA: Reduces nuclear export."; /evidence="ECO:0000269|PubMed:12235138
uniprot
proteins
pubmed
12235138
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22814378
uniprot
proteins
sequence_length
138
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12235138}. Nucleus {ECO:0000269|PubMed:12235138}. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner.
uniprot
proteins