Tmem98
entrez
303356
canonical
uniprot
Q6AYS5
canonical
ensembl
ENSRNOG00000021316
resolver
ensembl
ENSRNOG00055024884
resolver
ensembl
ENSRNOG00060027791
resolver
ensembl
ENSRNOG00065019091
resolver
ensp
ENSRNOP00000038394
resolver
ensp
ENSRNOP00055035030
resolver
ensp
ENSRNOP00060040142
resolver
ensp
ENSRNOP00065025614
resolver
enst
ENSRNOT00000037072
resolver
enst
ENSRNOT00055042902
resolver
enst
ENSRNOT00060048226
resolver
enst
ENSRNOT00065032100
resolver
genesymbol
Tmem98
resolver
uniprot_entry
TMM98_RAT
resolver
amino_acid_sequence
METVVIVAIGVLATIFLASFAALVVVCRQRYCRPRDLLQRYDSKPIVDLIGAMETQSEPSELELDDVVITNPHIEAILENEDWIEDASGLMSHCIAILKICHTLTEKLVAMTMGSGAKMKTSASVSDIIVVAKRISPRVDDVVKSMYPPLDPKLLDARTTALLLSVSHLVLVTRNACHLTGGLDWIDQSLSAAEEHLEVLREAALASEPDKSLPNPEGFLQEQSAI
uniprot
proteins
function
FUNCTION: Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1). {ECO:0000250|UniProtKB:Q91X86}.
uniprot
proteins
mass_dalton
24684
uniprot
proteins
protein_family
TMEM98 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
226
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q91X86}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9Y2Y6}. Cell membrane {ECO:0000250|UniProtKB:Q9Y2Y6}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9Y2Y6}. Secreted {ECO:0000250|UniProtKB:Q91X86}. Secreted, extracellular exosome {ECO:0000250|UniProtKB:Q9Y2Y6}. Note=Secreted by exosomes through a non-classical pathway. {ECO:0000250|UniProtKB:Q9Y2Y6}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins