SLC18B1
entrez
116843
canonical
uniprot
Q6NT16
canonical
ensembl
ENSG00000146409
resolver
ensp
ENSP00000275227
resolver
ensp
ENSP00000497768
resolver
ensp
ENSP00000665315
resolver
enst
ENST00000275227
resolver
enst
ENST00000647932
resolver
genesymbol
SLC18B1
resolver
genesymbol_syn
C6orf192
resolver
hgnc
HGNC:21573
resolver
uniprot
A0A3B3IT67
resolver
uniprot
A8K1K3
resolver
uniprot
B3KW77
resolver
uniprot
Q6ISF2
resolver
uniprot_entry
A0A3B3IT67_HUMAN
resolver
uniprot_entry
S18B1_HUMAN
resolver
uniprot_sec
A8K1K3
resolver
uniprot_sec
B3KW77
resolver
uniprot_sec
Q6ISF2
resolver
amino_acid_sequence
MEALGDLEGPRAPGGDDPAGSAGETPGWLSREQVFVLISAASVNLGSMMCYSILGPFFPKEAEKKGASNTIIGMIFGCFALFELLASLVFGNYLVHIGAKFMFVAGMFVSGGVTILFGVLDRVPDGPVFIAMCFLVRVMDAVSFAAAMTASSSILAKAFPNNVATVLGSLETFSGLGLILGPPVGGFLYQSFGYEVPFIVLGCVVLLMVPLNMYILPNYESDPGEHSFWKLIALPKVGLIAFVINSLSSCFGFLDPTLSLFVLEKFNLPAGYVGLVFLGMALSYAISSPLFGLLSDKRPPLRKWLLVFGNLITAGCYMLLGPVPILHIKSQLWLLVLILVVSGLSAGMSIIPTFPEILSCAHENGFEEGLSTLGLVSGLFSAMWSIGAFMGPTLGGFLYEKIGFEWAAAIQGLWALISGLAMGLFYLLEYSRRKRSKSQNILSTEEERTTLLPNET
uniprot
proteins
function
FUNCTION: Proton-coupled polyamine antiporter involved in the translocation of polyamines from cytosol into secretory vesicles prior to their release via exocytosis. Uses the electrochemical proton gradient generated by a V-type proton-pumping ATPase to couple the efflux of protons with the uptake of a polyamine molecule (PubMed:25355561). Facilitates vesicular storage of spermine and spermidine in astrocytes with an impact on glutamatergic neuronal transmission and memory formation (By similarity) (PubMed:25355561). Upon antigen stimulation, regulates polyamine accumulation and release in mast cell secretory granules, which in turn potentiates mast cell degranulation and histamine secretion (By similarity). {ECO:0000250|UniProtKB:D3Z5L6, ECO:0000269|PubMed:25355561}.
uniprot
proteins
mass_dalton
48869
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25355561
uniprot
proteins
sequence_length
456
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:D3Z5L6}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:D4A9K4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:D4A9K4}. Note=Colocalizes with VAMP3 and VAMP8 in mast cell secretory granules, which are distinct from histamine- and serotonin-containing granules (By similarity). Partly colocalizes with SYP in synaptic vesicles in hippocampal neurons. Colocalizes with SYP and VAMP2 in secretory vesicles of astrocytes (By similarity). {ECO:0000250|UniProtKB:D3Z5L6, ECO:0000250|UniProtKB:D4A9K4}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..54; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 71..91; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 101..121; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 128..148; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 162..184; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 196..216; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 231..251; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 273..293; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 305..325; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 332..352; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 378..398; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 408..428; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins