Cyren
entrez
500077
canonical
uniprot
Q6AYH4
canonical
ensembl
ENSRNOG00000026958
resolver
ensembl
ENSRNOG00055031003
resolver
ensembl
ENSRNOG00060026306
resolver
ensembl
ENSRNOG00065016389
resolver
ensp
ENSRNOP00000034483
resolver
ensp
ENSRNOP00055044492
resolver
ensp
ENSRNOP00060037846
resolver
ensp
ENSRNOP00065021417
resolver
enst
ENSRNOT00000029818
resolver
enst
ENSRNOT00055053772
resolver
enst
ENSRNOT00060045591
resolver
enst
ENSRNOT00065027275
resolver
genesymbol
Cyren
resolver
genesymbol_syn
Mri
resolver
uniprot_entry
CYREN_RAT
resolver
amino_acid_sequence
METLKSDNKKRVLPSWMTAPGNERKVVSVKTAKRKQTAAIRVGAATRAPAKETVYCMNEAEMVDVALGILIEGRKQEKPWEQPSLVAPDKLQLSPPCSESPHTSSPGSSSEEEDSRTDSPALGLSPARGPEASNSPCSRSPEEGKEEEDELKYVREIFFS
uniprot
proteins
function
FUNCTION: Cell-cycle-specific regulator of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair, which can act both as an activator or inhibitor of NHEJ, depending on the cell cycle phase (By similarity). Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present. Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination. Acts via interaction with XRCC5/Ku80 and XRCC6/Ku70 (By similarity). In contrast, acts as an activator of NHEJ during G1 phase of the cell cycle: promotes classical NHEJ in G1 phase cells via multivalent interactions that increase the affinity of DNA damage response proteins for DSB-associated chromatin. Also involved in immunoglobulin V(D)J recombination (By similarity). May also act as an indirect regulator of proteasome (By similarity). {ECO:0000250|UniProtKB:Q09HN1, ECO:0000250|UniProtKB:Q8BHZ5, ECO:0000250|UniProtKB:Q9BWK5}.
uniprot
proteins
mass_dalton
17487
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
160
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BWK5}. Nucleus {ECO:0000250|UniProtKB:Q9BWK5}. Chromosome {ECO:0000250|UniProtKB:Q8BHZ5}. Note=Nuclear localization may depend upon interaction with XRCC5/Ku80 and XRCC6/Ku70 heterodimer (By similarity). Localizes to DNA damage sites (By similarity). {ECO:0000250|UniProtKB:Q8BHZ5, ECO:0000250|UniProtKB:Q9BWK5}.
uniprot
proteins