Cdc20
entrez
107995
canonical
uniprot
Q9JJ66
canonical
ensembl
ENSMUSG00000006398
resolver
ensp
ENSMUSP00000006565
resolver
enst
ENSMUST00000006565
resolver
genesymbol
Cdc20
resolver
uniprot
Q3TGP1
resolver
uniprot
Q8BPG4
resolver
uniprot
Q99LK3
resolver
uniprot_entry
CDC20_MOUSE
resolver
uniprot_sec
Q3TGP1
resolver
uniprot_sec
Q8BPG4
resolver
uniprot_sec
Q99LK3
resolver
amino_acid_sequence
MAQFVFESDLHSLLQLDAPIPNAPVARWQRKAKEATGPAPSPMRAANRSHSAGRTPGRTPGKSSSKVQTTPSKPGGDRFIPQRSASQMEVASFLLSKENQPEDRGTPTKKEHQKAWSLNLNGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWNAGSGDILQLLQMEQPGDYISSVAWIKEGNYLAVGTSNAEVQLWDVQQQKRLRNMTSHSARVSSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNIVNVWPSGPGESGWAPLQTFTQHQGAVKAVAWCPWQSNILATGGGTSDRHIRIWNVCSGACLSAVDVHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTARVLGLTMSPDGATVASAAADETLRLWRCFEMDPALRREREKASVAKSSLIHQGIR
uniprot
proteins
function
FUNCTION: Substrate-specific adapter and activator of the anaphase promoting complex/cyclosome (APC/C) complex that confers substrate specificity by binding to substrates and targeting them to the APC/C complex for ubiquitination and degradation (By similarity). Essential for activating APC/C in the metaphase/anaphase transition of the cell cycle, targeting the degradation of cyclin B and securin (PubMed:32666501). Recognizes and binds the destruction box (D box), KEB box and ABBA motifs on protein substrates (By similarity). The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons (PubMed:19900895). CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (PubMed:19900895). The CDC20-APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41 (PubMed:34298015). Component of the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation until all chromosomes are properly attached to the mitotic spindle (PubMed:34298015). The MCC, which consists of CDC20, MAD2L1/MAD2, BUB1B/BUBR1 and BUB3, is a key player of the spindle assembly checkpoint (By similarity). The MCC-bound APC/C complex is inactive and this delays the metaphase/anaphase transition (By similarity). When the spindle assembly checkpoint is silenced, the MCC-APC/C complex recruits the E2 enzyme UBCH10 and triggers the auto-ubiquitination of CDC20 in the MCC, thereby reactivating APC/C for transition into anaphase (By similarity). {ECO:0000250|UniProtKB:Q12834, ECO:0000269|PubMed:19900895, ECO:0000269|PubMed:32666501, ECO:0000269|PubMed:34298015}.
uniprot
proteins
mass_dalton
54816
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Acetylated (PubMed:22014574). Deacetylated at Lys-66 by SIRT2; deacetylation enhances the interaction of CDC20 with CDC27, leading to activation of anaphase promoting complex/cyclosome (APC/C) (PubMed:22014574). {ECO:0000269|PubMed:22014574}.; PTM: Phosphorylated during mitosis (By similarity). Phosphorylated by BUB1 at Ser-41; Ser-72; Ser-92; Ser-153; Thr-157 and Ser-161 (By similarity). Phosphorylated by NEK2 (By similarity). {ECO:0000250|UniProtKB:Q12834}.; PTM: Dephosphorylated by CTDP1 (By similarity). {ECO:0000250|UniProtKB:Q12834}.; PTM: Ubiquitinated and degraded by the proteasome during spindle assembly checkpoint (By similarity). Deubiquitinated by USP44, leading to stabilization of the MAD2L1-CDC20-APC/C ternary complex, thereby preventing premature activation of the APC/C (By similarity). Ubiquitinated at Lys-490 during prometaphase (By similarity). Ubiquitination at Lys-485 and Lys-490 has no effect on its ability to bind the APC/C complex (By similarity). Ubiquitinated by UBR5 when not assembled in a multiprotein complex, leading to its degradation: UBR5 recognizes and binds a degron that is not accessible when CDC20 is part of a complex (By similarity). {ECO:0000250|UniProtKB:Q12834}.
uniprot
proteins
protein_family
WD repeat CDC20/Fizzy family
uniprot
proteins
pubmed
15280373
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15526037
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19900895
uniprot
proteins
pubmed
22014574
uniprot
proteins
pubmed
32666501
uniprot
proteins
pubmed
34298015
uniprot
proteins
sequence_length
499
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:34298015}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q12834}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q12834}.
uniprot
proteins