CHRNA6
entrez
8973
canonical
uniprot
Q15825
canonical
ensembl
ENSG00000147434
resolver
ensp
ENSP00000276410
resolver
ensp
ENSP00000433871
resolver
genesymbol
CHRNA6
resolver
hgnc
HGNC:15963
resolver
uniprot
B2R8V4
resolver
uniprot
B4DQH1
resolver
uniprot_entry
ACHA6_HUMAN
resolver
uniprot_sec
B2R8V4
resolver
uniprot_sec
B4DQH1
resolver
activity_regulation
ACTIVITY REGULATION: Activated by a myriad of ligands such as acetylcholine, cytisine and nicotine (PubMed:16835356). CHRNA6 nAChR activity is inhibited by the antagonists alpha-conotoxin MII and PIA, a small disulfide-constrained peptides from cone snails. {ECO:0000250|UniProtKB:Q9R0W9, ECO:0000269|PubMed:16835356}.
uniprot
proteins
amino_acid_sequence
MLTSKGQGFLHGGLCLWLCVFTPFFKGCVGCATEERLFHKLFSHYNQFIRPVENVSDPVTVHFEVAITQLANVDEVNQIMETNLWLRHIWNDYKLRWDPMEYDGIETLRVPADKIWKPDIVLYNNAVGDFQVEGKTKALLKYNGMITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIIDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVVPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPTTHTMPRWVKTVFLKLLPQVLLMRWPLDKTRGTGSDAVPRGLARRPAKGKLASHGEPRHLKECFHCHKSNELATSKRRLSHQPLQWVVENSEHSPEVEDVINSVQFIAENMKSHNETKEVEDDWKYVAMVVDRVFLWVFIIVCVFGTAGLFLQPLLGNTGKS
uniprot
proteins
function
FUNCTION: Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (Probable). CHRNA6 forms pentameric channels with CHRNB2, CHRNB3 and CHRNA4 that exhibit high sensitivity to ACh and nicotine and are predominantly expressed in only a few brain areas, including dopaminergic neurons, norepirephrine neurons and cells of the visual system (PubMed:16835356). nAChrs containing CHRNA6 subunits mediate endogenous cholinergic modulation of dopamine and gamma-aminobutyric acid (GABA) release in response to nicotine at nerve terminals. {ECO:0000250|UniProtKB:Q9R0W9, ECO:0000269|PubMed:16835356, ECO:0000305|PubMed:16835356}.
uniprot
proteins
mass_dalton
56898
uniprot
proteins
protein_family
Acetylcholine receptor (TC 1.A.9.1) subfamily
uniprot
proteins
protein_family
Alpha-6/CHRNA6 sub-subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
16835356
uniprot
proteins
pubmed
27344019
uniprot
proteins
pubmed
8906617
uniprot
proteins
sequence_length
494
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Synaptic cell membrane {ECO:0000250|UniProtKB:Q9R0W9}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 240..264; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 272..290; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 306..327; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 466..484; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins