AVP
entrez
551
canonical
uniprot
P01185
canonical
ensembl
ENSG00000101200
resolver
ensp
ENSP00000369647
resolver
enst
ENST00000380293
resolver
genesymbol
AVP
resolver
genesymbol_syn
ARVP
resolver
genesymbol_syn
VP
resolver
hgnc
HGNC:894
resolver
uniprot
A0AV35
resolver
uniprot
O14935
resolver
uniprot
X5DQP6
resolver
uniprot_entry
NEU2_HUMAN
resolver
uniprot_entry
X5DQP6_HUMAN
resolver
uniprot_sec
A0AV35
resolver
uniprot_sec
O14935
resolver
amino_acid_sequence
MPDTMLPACFLGLLAFSSACYFQNCPRGGKRAMSDLELRQCLPCGPGGKGRCFGPSICCADELGCFVGTAEALRCQEENYLPSPCQSGQKACGSGGRCAAFGVCCNDESCVTEPECREGFHRRARASDRSNATQLDGPAGALLLRLVQLAGAPEPFEPAQPDAY
uniprot
proteins
disease_involvement
DISEASE: Diabetes insipidus, neurohypophyseal (NDI) [MIM:125700]: A disease characterized by persistent thirst, polydipsia and polyuria. Affected individuals are apparently normal at birth, but characteristically develop symptoms of vasopressin deficiency during childhood. {ECO:0000269|PubMed:10329029, ECO:0000269|PubMed:10369876, ECO:0000269|PubMed:10487710, ECO:0000269|PubMed:10677561, ECO:0000269|PubMed:11017955, ECO:0000269|PubMed:11150885, ECO:0000269|PubMed:11161827, ECO:0000269|PubMed:11395505, ECO:0000269|PubMed:11443218, ECO:0000269|PubMed:11748489, ECO:0000269|PubMed:11980620, ECO:0000269|PubMed:12012274, ECO:0000269|PubMed:12107248, ECO:0000269|PubMed:12359138, ECO:0000269|PubMed:12519420, ECO:0000269|PubMed:12931042, ECO:0000269|PubMed:14510916, ECO:0000269|PubMed:14673472, ECO:0000269|PubMed:15538939, ECO:0000269|PubMed:15644573, ECO:0000269|PubMed:16006166, ECO:0000269|PubMed:1740104, ECO:0000269|PubMed:18316776, ECO:0000269|PubMed:7714110, ECO:0000269|PubMed:8045958, ECO:0000269|PubMed:8103767, ECO:0000269|PubMed:8370682, ECO:0000269|PubMed:8514868, ECO:0000269|PubMed:8554046, ECO:0000269|PubMed:8626836, ECO:0000269|PubMed:9360520, ECO:0000269|PubMed:9580132, ECO:0000269|PubMed:9814475}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Precursor of Arg-vasopressin, an antidiuretic hormone, and neurophysin 2, its carrier protein. {ECO:0000269|PubMed:2991279}.; FUNCTION: [Arg-vasopressin]: Has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels. Acts by binding to vasopressin receptors (V1bR/AVPR1B, V1aR/AVPR1A, and V2R/AVPR2). {ECO:0000269|PubMed:18174156, ECO:0000269|PubMed:33664408, ECO:0000269|PubMed:33742150}.; FUNCTION: [Neurophysin 2]: Carrier protein that binds to and transports Arg-vasopressin from the hypothalamus to the posterior pituitary gland, protecting it from degradation and facilitating its release. {ECO:0000250|UniProtKB:P01186}.
uniprot
proteins
mass_dalton
17325
uniprot
proteins
mutagenesis
MUTAGEN 28; /note="G->V: Gain of antagonist activity on V1aR/AVPR1A (and loss of agonist activity on this receptor). 42-fold decrease in affinity for V1aR/AVPR1A, 2000-fold decrease in affinity for V1bR/AVPR1B, 5-fold decrease in affinity for V2R/AVPR2 and no change in affinity for oxytocin receptor (OXTR)."; /evidence="ECO:0000269|PubMed:18174156
uniprot
proteins
post_translational_modification
PTM: Synthesized as a large inactive precursor protein, which is cleaved into Arg-vasopressin and neurophysin 2 by endopeptidases, such as neuroendocrine convertases PCSK1 and PCSK2 (By similarity). Arg-vasopressin is then amidated at the C-terminus, completing its activation (PubMed:13591312). {ECO:0000250|UniProtKB:P01186, ECO:0000269|PubMed:13591312}.; PTM: [Arg-vasopressin]: Amidated at the C-terminus by alpha-amidating monooxygenase (PAM), completing its activation. {ECO:0000269|PubMed:13591312}.
uniprot
proteins
protein_family
Vasopressin/oxytocin family
uniprot
proteins
pubmed
10329029
uniprot
proteins
pubmed
10369876
uniprot
proteins
pubmed
10487710
uniprot
proteins
pubmed
10677561
uniprot
proteins
pubmed
11017955
uniprot
proteins
pubmed
11150885
uniprot
proteins
pubmed
11161827
uniprot
proteins
pubmed
11395505
uniprot
proteins
pubmed
11443218
uniprot
proteins
pubmed
11748489
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
11980620
uniprot
proteins
pubmed
12012274
uniprot
proteins
pubmed
12107248
uniprot
proteins
pubmed
12359138
uniprot
proteins
pubmed
12519420
uniprot
proteins
pubmed
12931042
uniprot
proteins
pubmed
13591312
uniprot
proteins
pubmed
14510916
uniprot
proteins
pubmed
14673472
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15538939
uniprot
proteins
pubmed
15644573
uniprot
proteins
pubmed
16006166
uniprot
proteins
pubmed
1740104
uniprot
proteins
pubmed
18174156
uniprot
proteins
pubmed
18316776
uniprot
proteins
pubmed
2991279
uniprot
proteins
pubmed
33664408
uniprot
proteins
pubmed
33713620
uniprot
proteins
pubmed
33742150
uniprot
proteins
pubmed
3768139
uniprot
proteins
pubmed
4065330
uniprot
proteins
pubmed
6574452
uniprot
proteins
pubmed
7271787
uniprot
proteins
pubmed
7714110
uniprot
proteins
pubmed
8045958
uniprot
proteins
pubmed
8103767
uniprot
proteins
pubmed
8370682
uniprot
proteins
pubmed
8514868
uniprot
proteins
pubmed
8554046
uniprot
proteins
pubmed
8626836
uniprot
proteins
pubmed
9360520
uniprot
proteins
pubmed
9580132
uniprot
proteins
pubmed
9814475
uniprot
proteins
sequence_length
164
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:P01186}. Note=The precursor protein is packaged into neurosecretory granules. {ECO:0000250|UniProtKB:P01186}.; SUBCELLULAR LOCATION: [Arg-vasopressin]: Secreted {ECO:0000269|PubMed:33713620}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:P01186}. Note=Following processing, Arg-vasopressin and neurophysin 2 are transported to the posterior pituitary and stored in neurosecretory granules at the nerve termini until secreted. {ECO:0000250|UniProtKB:P01186}.; SUBCELLULAR LOCATION: [Neurophysin 2]: Secreted {ECO:0000250|UniProtKB:P01186}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:P01186}. Note=Following processing, Arg-vasopressin and neurophysin 2 are transported to the posterior pituitary and stored in neurosecretory granules at the nerve termini until secreted. {ECO:0000250|UniProtKB:P01186}.
uniprot
proteins