PDE3B
entrez
5140
canonical
uniprot
Q13370
canonical
ensembl
ENSG00000152270
resolver
ensp
ENSP00000282096
resolver
ensp
ENSP00000388644
resolver
ensp
ENSP00000540683
resolver
ensp
ENSP00000673320
resolver
ensp
ENSP00000673321
resolver
genesymbol
PDE3B
resolver
hgnc
HGNC:8779
resolver
uniprot
A7E2E5
resolver
uniprot
B7ZM37
resolver
uniprot
O00639
resolver
uniprot
Q14408
resolver
uniprot
Q6SEI4
resolver
uniprot_entry
A7E2E5_HUMAN
resolver
uniprot_entry
PDE3B_HUMAN
resolver
uniprot_sec
B7ZM37
resolver
uniprot_sec
O00639
resolver
uniprot_sec
Q14408
resolver
uniprot_sec
Q6SEI4
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by cGMP. {ECO:0000250|UniProtKB:Q63085}.
uniprot
proteins
amino_acid_sequence
MRRDERDAKAMRSLQPPDGAGSPPESLRNGYVKSCVSPLRQDPPRGFFFHLCRFCNVELRPPPASPQQPRRCSPFCRARLSLGALAAFVLALLLGAEPESWAAGAAWLRTLLSVCSHSLSPLFSIACAFFFLTCFLTRTKRGPGPGRSCGSWWLLALPACCYLGDFLVWQWWSWPWGDGDAGSAAPHTPPEAAAGRLLLVLSCVGLLLTLAHPLRLRHCVLVLLLASFVWWVSFTSLGSLPSALRPLLSGLVGGAGCLLALGLDHFFQIREAPLHPRLSSAAEEKVPVIRPRRRSSCVSLGETAASYYGSCKIFRRPSLPCISREQMILWDWDLKQWYKPHYQNSGGGNGVDLSVLNEARNMVSDLLTDPSLPPQVISSLRSISSLMGAFSGSCRPKINPLTPFPGFYPCSEIEDPAEKGDRKLNKGLNRNSLPTPQLRRSSGTSGLLPVEQSSRWDRNNGKRPHQEFGISSQGCYLNGPFNSNLLTIPKQRSSSVSLTHHVGLRRAGVLSSLSPVNSSNHGPVSTGSLTNRSPIEFPDTADFLNKPSVILQRSLGNAPNTPDFYQQLRNSDSNLCNSCGHQMLKYVSTSESDGTDCCSGKSGEEENIFSKESFKLMETQQEEETEKKDSRKLFQEGDKWLTEEAQSEQQTNIEQEVSLDLILVEEYDSLIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTGLLEIFKIPTQQFMNYFRALENGYRDIPYHNRIHATDVLHAVWYLTTRPVPGLQQIHNGCGTGNETDSDGRINHGRIAYISSKSCSNPDESYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGDEEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWLEAEEDNDTESGDDEDGEELDTEDEEMENNLNPKPPRRKSRRRIFCQLMHHLTENHKIWKEIVEEEEKCKADGNKLQVENSSLPQADEIQVIEEADEEE
uniprot
proteins
ec_number
3.1.4.17
uniprot
proteins
function
FUNCTION: Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process (PubMed:14592490, PubMed:21393242). Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling (PubMed:21393242). Controls cardiac contractility by reducing cAMP concentration in cardiocytes (By similarity). {ECO:0000250|UniProtKB:Q61409, ECO:0000269|PubMed:14592490, ECO:0000269|PubMed:21393242}.
uniprot
proteins
mass_dalton
124333
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="R->A: Loss of interaction with RAPGEF3."; /evidence="ECO:0000269|PubMed:21393242"; MUTAGEN 3; /note="R->A: Loss of interaction with RAPGEF3."; /evidence="ECO:0000269|PubMed:21393242"; MUTAGEN 6; /note="R->A: Loss of interaction with RAPGEF3."; /evidence="ECO:0000269|PubMed:21393242"; MUTAGEN 8; /note="A->D: Loss of interaction with RAPGEF3."; /evidence="ECO:0000269|PubMed:21393242"; MUTAGEN 9; /note="K->A: Loss of interaction with RAPGEF3."; /evidence="ECO:0000269|PubMed:21393242"; MUTAGEN 10; /note="A->D: Loss of interaction with RAPGEF3."; /evidence="ECO:0000269|PubMed:21393242"; MUTAGEN 12; /note="R->A: Loss of interaction with RAPGEF3."; /evidence="ECO:0000269|PubMed:21393242"; MUTAGEN 439; /note="R->A: Loss of interaction with PIK3R6."; /evidence="ECO:0000269|PubMed:21393242"; MUTAGEN 440; /note="R->A: Loss of interaction with PIK3R6."; /evidence="ECO:0000269|PubMed:21393242"; MUTAGEN 445; /note="S->A: Loss of interaction with PIK3R6."; /evidence="ECO:0000269|PubMed:21393242"; MUTAGEN 449; /note="P->A: Loss of interaction with PIK3R6."; /evidence="ECO:0000269|PubMed:21393242
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-295 mediates insulin-induced activation of PDE3B. {ECO:0000250|UniProtKB:Q61409}.
uniprot
proteins
protein_family
Cyclic nucleotide phosphodiesterase family
uniprot
proteins
protein_family
PDE3 subfamily
uniprot
proteins
pubmed
14592490
uniprot
proteins
pubmed
15147193
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16702214
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21393242
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8706823
uniprot
proteins
pubmed
8884271
uniprot
proteins
pubmed
8921398
uniprot
proteins
sequence_length
1112
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q61409}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 88..108; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 117..137; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 152..172; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 192..212; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 220..240; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 247..267; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins