RNP24
entrez
10959
canonical
uniprot
Q15363
canonical
ensembl
ENSG00000086598
resolver
ensp
ENSP00000262225
resolver
ensp
ENSP00000554085
resolver
enst
ENST00000262225
resolver
genesymbol
RNP24
resolver
genesymbol
TMED2
resolver
genesymbol_syn
RNP24
resolver
genesymbol_syn
TMED2
resolver
hgnc
HGNC:16996
resolver
uniprot
Q6FHT8
resolver
uniprot_entry
Q6FHT8_HUMAN
resolver
uniprot_entry
TMED2_HUMAN
resolver
amino_acid_sequence
MVTLAELLVLLAALLATVSGYFVSIDAHAEECFFERVTSGTKMGLIFEVAEGGFLDIDVEITGPDNKGIYKGDRESSGKYTFAAHMDGTYKFCFSNRMSTMTPKIVMFTIDIGEAPKGQDMETEAHQNKLEEMINELAVAMTAVKHEQEYMEVRERIHRAINDNTNSRVVLWSFFEALVLVAMTLGQIYYLKRFFEVRRVV
uniprot
proteins
function
FUNCTION: Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway but also in post-Golgi membranes. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act together with TMED10 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipid raft-like microdomains of the ER. Recognizes GPI anchors structural remodeled in the ER by PGAP1 and MPPE1. In COPI vesicle-mediated retrograde transport inhibits the GTPase-activating activity of ARFGAP1 towards ARF1 thus preventing immature uncoating and allowing cargo selection to take place. Involved in trafficking of G protein-coupled receptors (GPCRs). Regulates F2RL1, OPRM1 and P2RY4 exocytic trafficking from the Golgi to the plasma membrane thus contributing to receptor resensitization. Facilitates CASR maturation and stabilization in the early secretory pathway and increases CASR plasma membrane targeting. Proposed to be involved in organization of intracellular membranes such as the maintenance of the Golgi apparatus. May also play a role in the biosynthesis of secreted cargo such as eventual processing. {ECO:0000269|PubMed:10761932, ECO:0000269|PubMed:17693410, ECO:0000269|PubMed:20361938, ECO:0000269|PubMed:20427317, ECO:0000269|PubMed:21219331}.
uniprot
proteins
mass_dalton
22761
uniprot
proteins
mutagenesis
MUTAGEN 194..195; /note="FF->AA: Disrupts association with coatomer; when associated with S-198-199-S."; /evidence="ECO:0000269|PubMed:10761932, ECO:0000269|PubMed:20361938"; MUTAGEN 194..195; /note="FF->AA: Reduced surface and total expression of CASR."; /evidence="ECO:0000269|PubMed:10761932, ECO:0000269|PubMed:20361938"; MUTAGEN 198..199; /note="RR->SS: Disrupts association with coatomer; when associated with A-194-195-A."; /evidence="ECO:0000269|PubMed:10761932"; MUTAGEN 198..199; /note="RR->SS: No inhibition of coatomer-dependent GTP hydrolysis."; /evidence="ECO:0000269|PubMed:10761932
uniprot
proteins
protein_family
EMP24/GP25L family
uniprot
proteins
pubmed
10359607
uniprot
proteins
pubmed
10761932
uniprot
proteins
pubmed
10852829
uniprot
proteins
pubmed
12237308
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16940185
uniprot
proteins
pubmed
17321752
uniprot
proteins
pubmed
17693410
uniprot
proteins
pubmed
18287528
uniprot
proteins
pubmed
20361938
uniprot
proteins
pubmed
20427317
uniprot
proteins
pubmed
21219331
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27569046
uniprot
proteins
pubmed
8663407
uniprot
proteins
pubmed
9472029
uniprot
proteins
sequence_length
201
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000269|PubMed:9472029}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:12237308}; Single-pass type I membrane protein {ECO:0000255}. Note=Cycles between compartments of the early secretatory pathway. {ECO:0000269|PubMed:12237308}.
uniprot
proteins
transmembrane_region
TRANSMEM 169..189; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins