Akr1c6
entrez
83702
canonical
uniprot
P70694
canonical
ensembl
ENSMUSG00000021210
resolver
ensp
ENSMUSP00000021630
resolver
ensp
ENSMUSP00000266208
resolver
enst
ENSMUST00000021630
resolver
genesymbol
Akr1c6
resolver
genesymbol_syn
Hsd17b5
resolver
uniprot
Q3UEM0
resolver
uniprot_entry
DHB5_MOUSE
resolver
uniprot_entry
Q3UEM0_MOUSE
resolver
amino_acid_sequence
MDSKQQTVRLSDGHFIPILGFGTYAPQEVPKSKATEATKIAIDAGFRHIDSASMYQNEKEVGLAIRSKIADGTVKREDIFYTSKVWCTFHRPELVRVCLEQSLKQLQLDYVDLYLIHFPMAMKPGENYLPKDENGKLIYDAVDICDTWEAMEKCKDAGLAKSIGVSNFNRRQLEKILKKPGLKYKPVCNQVECHPYLNQGKLLDFCRSKDIVLVAYSALGSHREKQWVDQSSPVLLDNPVLGSMAKKYNRTPALIALRYQLQRGVVVLAKSFSEKRIKENMQVFEFQLTSEDMKVLDDLNKNIRYISGSSFKDHPDFPFWDEY
uniprot
proteins
ec_number
1.1.1.-
uniprot
proteins
function
FUNCTION: Active toward androgens, estrogens, and xenobiotic substrates. Also exhibits low 20 alpha-HSD activity. Shows a-stereospecificity in hydrogen transfer between cofactors and substrates (A-specific). Preferentially catalyzes the reduction of 4-androstenedione, 5-alpha-androstane-3,17-dione, androsterone and dehydroepiandrosterone to testosterone, dihydrotestosterone, 5-alpha-androstane-3-alpha,17-beta-diol and 5-androstene-3-beta,17-beta-diol, respectively. {ECO:0000269|PubMed:10500239}.
uniprot
proteins
mass_dalton
37048
uniprot
proteins
post_translational_modification
PTM: Three forms are detected, probably due to post-translational modifications.
uniprot
proteins
protein_family
Aldo/keto reductase family
uniprot
proteins
pubmed
10500239
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7737980
uniprot
proteins
sequence_length
323
uniprot
proteins