Pde6c
entrez
110855
canonical
uniprot
Q91ZQ1
canonical
ensembl
ENSMUSG00000024992
resolver
ensp
ENSMUSP00000025956
resolver
ensp
ENSMUSP00000107948
resolver
genesymbol
Pde6c
resolver
uniprot
Q8R0D4
resolver
uniprot_entry
PDE6C_MOUSE
resolver
uniprot_sec
Q8R0D4
resolver
amino_acid_sequence
MGEISQEAVERYLEKNPCFAKEYFDKKLRVEALGVIFKNSHAGVQTGLSLPEMTQVEESAVCLELLQCMQDEAGSAEQMAHRALQRLAQLLQADCCSMFSCRARNGIPEVASRLLNVTPTSKFEDNLVAPDREVVFPLDIGIVGWVAHVKKALNVSDVKKNSHFSDFMDKQTGYVTRNLLAVPIVAGKEVLAVVMAVNKISAPEFSKQDEEVFSKYLSFVAVALRLQHTSYLYSVESRRSQILMWSANKVFEELTDVERQFHKALYTIRTYLNCDRYSIGLLDMTKEKEFYDEWPIKLGEVEPYKGPKTPDGREIIFYKIIDYILHGKEEINVIPSPPADHWTLVSGLPTYVAENGFICNMLNAPADEYFTFQKGPVDETGWVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEHITETLTQFLGWSLLNTDTYERVNKLESRKDIAQEMVMNLTKATPDEISSILKFKEKLNVEVIEECEERQLLAILKEDLPDPRTADLYEFCFSDFPITEHELVKCGLRLFLEINVVEKFKVPVEVLTRWMYTVRKGYRPVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSPLARLHGTSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQKIVDTCEQMQSEEETIKYVTSDPTKKEVIMAMMMTACDLSAITKPWEVQSQVALLVANEFWEQGDLERTVLQQQPIPMMDRSKKDELPKLQVGFIDFVCTFVYKEFSRFHGEITPMLNGLQNNRVEWKSLAEEYEAKVKVTEEEAGKQEEEASDGKAATDLGGSAEDKKSKTCLML
uniprot
proteins
ec_number
3.1.4.35
uniprot
proteins
function
FUNCTION: Catalytic alpha subunit of the cone-specific cGMP phosphodiesterase (PDE6) complex, which hydrolyzes 3',5'-cyclic GMP as part of the phototransduction cascade (PubMed:37384398). The PDE6 holoenzyme consists of two catalytic alpha subunits (PDE6C) and two inhibitory gamma subunits (PDE6H) (By similarity). Light-activated GNAT2 relieves gamma subunit-mediated inhibition, allowing the catalytic subunits to hydrolyze cGMP and mediate visual signal transduction and amplification. The resulting decrease in cytosolic cGMP levels triggers the closure of cGMP-gated cation channels at the plasma membrane, leading to hyperpolarization of cone photoreceptors (By similarity). The catalytic site can adopt partially open conformations even in the inhibited state, contributing to the higher basal activity and rapid response kinetics characteristic of cones compared to rods (By similarity). {ECO:0000250|UniProtKB:P11541, ECO:0000250|UniProtKB:P51160, ECO:0000269|PubMed:37384398}.
uniprot
proteins
mass_dalton
98785
uniprot
proteins
post_translational_modification
PTM: Prenylated. This modification is required for membrane association and for efficient targeting and retention in cone outer segments. {ECO:0000269|PubMed:37384398}.
uniprot
proteins
protein_family
Cyclic nucleotide phosphodiesterase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
37384398
uniprot
proteins
sequence_length
861
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Photoreceptor outer segment membrane {ECO:0000269|PubMed:37384398}; Lipid-anchor {ECO:0000269|PubMed:37384398}. Note=Localized in cone outer segment disk membranes. {ECO:0000269|PubMed:37384398}.
uniprot
proteins