Gbf1
entrez
107338
canonical
uniprot
Q6DFZ1
canonical
ensembl
ENSMUSG00000025224
resolver
ensp
ENSMUSP00000026254
resolver
ensp
ENSMUSP00000203779
resolver
ensp
ENSMUSP00000203780
resolver
ensp
ENSMUSP00000203782
resolver
enst
ENSMUST00000026254
resolver
genesymbol
Gbf1
resolver
uniprot_entry
GBF1_MOUSE
resolver
amino_acid_sequence
MVDKNIYIIQGEINIVVGAIKRNARWSTHIPLDEERDPLLHSFSNLKEVLNSVTELSEIEPNVFLRPFLEVIRSEDTTGPITGLALTSVNKFLSYALIDPTHEGTAEGMENMADAVTHARFVGTDPASDEVVLMKILQVLRTLLLTPVGTHLTNESVCEIMQSCFRICFEMRLSELLRKSAEHTLVDMVQLLFTRLPQFKEEPKSYVGTNMKKLKMRAGGMSDSSKWKKQKRSPRPPRHTTKVTPGSELPTPNGATLPSNLTGGVPFIDAPTSISSASSEAASTVVSPCTDSGLELSSQTTSKEDLTDLEQAGSPREITTSEPGSSEMGASDQLDPQEGAHVEKAQSASVESIPEVLEECTSPADHSDSASVHDMDYVNPRGVRFTQSSQKEGTALVPYGLPCIRELFRFLISLTNPHDRHNSEVMIHMGLHLLTVALESAPVAQCQTLLGLIKDEMCRHLFQLLSVERLNLYAASLRVCFLLFESMREHLKFQLEMYIKKLMEIITVENPKMPYEMKEMALEAVVQLWRIPSFVTELYINYDCDYYCSNLFEDLTKLLSKNAFPVSGQLYTTHLLSLDALLTVIDSTESHCQAKVLNTLNQQEKKETARPGFEAVDGNPETNKSERATSDGKSTGVALDARGLHFPSGGWLSTEHGKPGCRDLEEAGDSGADKKFTRKPPRFSCLLPDPRELIEIKNKKKLLITGTEQFNQKPKKGIQFLQEKGLLTIPMDNTEVAQWLRENPRLDKKMIGEFVSDRKNMDLLESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVIHRLLEVFTEHWRSCNGSPFANSDACFALAYAVIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGKDFEQDILEDMYHAIKNEEIVMPEEQTGLVRENYVWSVLLHRGASPEGVFLRVPPGSYDLDLFTMTWGPTIAALSYVFDKSLEETIIQKAISGFRKCAMISAHYGLSDVFDNLIISLCKFTALSSESIENLPSVFGSNPKAHIAAKTVFHLAHRHGDILREGWKNIMEAMLQLFRAQLLPKAMVEVEDFVDPNGKISLQREETPSNRGESTVLSFVSWLTLSGPEQSSVRGPSTENQEAKRVALDCIKQCDPEKMITESKFLQLESLQELMKALVSVTPDEETYDEEDAAFCLEMLLRIVLENRDRVGCVWQTVRDHLYHLCVQAQDFCFLVERAVVGLLRLAIRLLRREEISGQVLLSLRILLLMKPSVLSRVSHQVAYGLHELLKTNAANIHSGDDWATLFTLLECIGSGVKPPDALQATARADAPDAGAQSDSELPSYHQNDVSLDRGYTSDSEVYTDHGRPGKIHRSATDADMVNSGWLVVGKDDIDNSKPGAGLSRPGPSPLVNQYSLTVGLDLGPHDTKSLLKCVESLSFIVRDAAHITPDNFELCVKTLRIFVEASLNGGCKSQDKRSKSHKYDSKGNRFKKKPKEGSMLRRPRGSNQHATRGGHSDEEEDEGVPASYHTVSLQVSQDLLDLMHTLHTRAASIYSSWAEEQRHLEGGGQKIEADSRTLWAHCWCPLLQGIACLCCDARRQVRMQALTYLQRALLVHDLQKLDALEWESCFNKVLFPLLTKLLENISPADVGGMEETRMRASTLLSKVFLQHLSPLLSLSTFAALWLTILDFMDKYMHAGSSDLLSEAIPESLKNMLLVMDTAEIFHSADARGGGPSALWEITWERIDCFLPHLRDELFKQTVIQDPMPAEPHSQKPLASTHLTSAAGDPRMPGHPPLPEIPSEMGVCDSEKPESTRAPSSSSPGSPMASSPSKLSPAQEGPPPLTQPPLILQPLTSPLQVGVPPMTLPIILNPALIEATSPVPLLATPRPTDPIPTSEVN
uniprot
proteins
function
FUNCTION: Guanine-nucleotide exchange factor (GEF) for members of the Arf family of small GTPases involved in trafficking in the early secretory pathway; its GEF activity initiates the coating of nascent vesicles via the localized generation of activated ARFs through replacement of GDP with GTP. Recruitment to cis-Golgi membranes requires membrane association of Arf-GDP and can be regulated by ARF1, ARF3, ARF4 and ARF5. Involved in the recruitment of the COPI coat complex to the endoplasmic reticulum exit sites (ERES), and the endoplasmic reticulum-Golgi intermediate (ERGIC) and cis-Golgi compartments which implicates ARF1 activation. Involved in COPI vesicle-dependent retrograde transport from the ERGIC and cis-Golgi compartments to the endoplasmic reticulum (ER) (By similarity). Involved in the trans-Golgi network recruitment of GGA1, GGA2, GGA3, BIG1, BIG2, and the AP-1 adaptor protein complex related to chlathrin-dependent transport; the function requires its GEF activity (probably at least in part on ARF4 and ARF5) (By similarity). Has GEF activity towards ARF1 (By similarity). Has in vitro GEF activity towards ARF5 (By similarity). Involved in the processing of PSAP (By similarity). Required for the assembly of the Golgi apparatus (By similarity). The AMPK-phosphorylated form is involved in Golgi disassembly during mitosis and under stress conditions (By similarity). May be involved in the COPI vesicle-dependent recruitment of PNPLA2 to lipid droplets; however, this function is under debate (By similarity). In neutrophils, involved in G protein-coupled receptor (GPCR)-mediated chemotaxis und superoxide production. Proposed to be recruited by phosphatidylinositol-phosphates generated upon GPCR stimulation to the leading edge where it recruits and activates ARF1, and is involved in recruitment of GIT2 and the NADPH oxidase complex (By similarity). Plays a role in maintaining mitochondrial morphology (By similarity). {ECO:0000250|UniProtKB:Q92538, ECO:0000250|UniProtKB:Q9R1D7}.
uniprot
proteins
mass_dalton
206782
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
32937143
uniprot
proteins
sequence_length
1861
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250|UniProtKB:Q92538}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250|UniProtKB:Q92538}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q92538}. Golgi apparatus {ECO:0000250|UniProtKB:Q92538}. Cytoplasm {ECO:0000250|UniProtKB:Q92538}. Lipid droplet {ECO:0000250|UniProtKB:Q92538}. Membrane; Peripheral membrane protein {ECO:0000305}. Note=Cycles rapidly on and off early Golgi membranes. Stabilized on membranes when complexed with ARF1-GDP and is released from both ARF1 and membranes after it catalyzes GDP displacement and ARF1 binds GTP. Continuous cycles of recruitment and dissociation of GBF1 to membranes are required for sustained ARF activation and COP I recruitment (By similarity). {ECO:0000250|UniProtKB:Q92538}.
uniprot
proteins