BAZ1A
entrez
11177
canonical
uniprot
Q9NRL2
canonical
ensembl
ENSG00000198604
resolver
ensp
ENSP00000351555
resolver
ensp
ENSP00000353458
resolver
ensp
ENSP00000604281
resolver
ensp
ENSP00000604283
resolver
genesymbol
BAZ1A
resolver
genesymbol_syn
ACF1
resolver
genesymbol_syn
WCRF180
resolver
hgnc
HGNC:960
resolver
uniprot
Q9NZ15
resolver
uniprot
Q9P065
resolver
uniprot
Q9UIG1
resolver
uniprot
Q9Y3V3
resolver
uniprot_entry
BAZ1A_HUMAN
resolver
uniprot_sec
Q9NZ15
resolver
uniprot_sec
Q9P065
resolver
uniprot_sec
Q9UIG1
resolver
uniprot_sec
Q9Y3V3
resolver
amino_acid_sequence
MPLLHRKPFVRQKPPADLRPDEEVFYCKVTNEIFRHYDDFFERTILCNSLVWSCAVTGRPGLTYQEALESEKKARQNLQSFPEPLIIPVLYLTSLTHRSRLHEICDDIFAYVKDRYFVEETVEVIRNNGARLQCRILEVLPPSHQNGFANGHVNSVDGETIIISDSDDSETQSCSFQNGKKKDAIDPLLFKYKVQPTKKELHESAIVKATQISRRKHLFSRDKLKLFLKQHCEPQDGVIKIKASSLSTYKIAEQDFSYFFPDDPPTFIFSPANRRRGRPPKRIHISQEDNVANKQTLASYRSKATKERDKLLKQEEMKSLAFEKAKLKREKADALEAKKKEKEDKEKKREELKKIVEEERLKKKEEKERLKVEREKEREKLREEKRKYVEYLKQWSKPREDMECDDLKELPEPTPVKTRLPPEIFGDALMVLEFLNAFGELFDLQDEFPDGVTLEVLEEALVGNDSEGPLCELLFFFLTAIFQAIAEEEEEVAKEQLTDADTKDLTEALDEDADPTKSALSAVASLAAAWPQLHQGCSLKSLDLDSCTLSEILRLHILASGADVTSANAKYRYQKRGGFDATDDACMELRLSNPSLVKKLSSTSVYDLTPGEKMKILHALCGKLLTLVSTRDFIEDYVDILRQAKQEFRELKAEQHRKEREEAAARIRKRKEEKLKEQEQKMKEKQEKLKEDEQRNSTADISIGEEEREDFDTSIESKDTEQKELDQDMVTEDEDDPGSHKRGRRGKRGQNGFKEFTRQEQINCVTREPLTADEEEALKQEHQRKEKELLEKIQSAIACTNIFPLGRDRMYRRYWIFPSIPGLFIEEDYSGLTEDMLLPRPSSFQNNVQSQDPQVSTKTGEPLMSESTSNIDQGPRDHSVQLPKPVHKPNRWCFYSSCEQLDQLIEALNSRGHRESALKETLLQEKSRICAQLARFSEEKFHFSDKPQPDSKPTYSRGRSSNAYDPSQMCAEKQLELRLRDFLLDIEDRIYQGTLGAIKVTDRHIWRSALESGRYELLSEENKENGIIKTVNEDVEEMEIDEQTKVIVKDRLLGIKTETPSTVSTNASTPQSVSSVVHYLAMALFQIEQGIERRFLKAPLDASDSGRSYKTVLDRWRESLLSSASLSQVFLHLSTLDRSVIWSKSILNARCKICRKKGDAENMVLCDGCDRGHHTYCVRPKLKTVPEGDWFCPECRPKQRSRRLSSRQRPSLESDEDVEDSMGGEDDEVDGDEEEGQSEEEEYEVEQDEDDSQEEEEVSLPKRGRPQVRLPVKTRGKLSSSFSSRGQQQEPGRYPSRSQQSTPKTTVSSKTGRSLRKINSAPPTETKSLRIASRSTRHSHGPLQADVFVELLSPRRKRRGRKSANNTPENSPNFPNFRVIATKSSEQSRSVNIASKLSLQESESKRRCRKRQSPEPSPVTLGRRSSGRQGGVHELSAFEQLVVELVRHDDSWPFLKLVSKIQVPDYYDIIKKPIALNIIREKVNKCEYKLASEFIDDIELMFSNCFEYNPRNTSEAKAGTRLQAFFHIQAQKLGLHVTPSNVDQVSTPPAAKKSRI
uniprot
proteins
function
FUNCTION: Regulatory subunit of the ATP-dependent ACF-1 and ACF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and slide edge- and center-positioned histone octamers away from their original location on the DNA template to facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:17099699, PubMed:28801535). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template in an ATP-dependent manner (PubMed:14759371, PubMed:17099699, PubMed:28801535). The ACF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the ACF-5 ISWI chromatin remodeling complex (PubMed:28801535). Has a role in sensing the length of DNA which flank nucleosomes, which modulates the nucleosome spacing activity of the ACF-5 ISWI chromatin remodeling complex (PubMed:17099699). Involved in DNA replication and together with SMARCA5/SNF2H is required for replication of pericentric heterochromatin in S-phase (PubMed:12434153). May have a role in nuclear receptor-mediated transcription repression (PubMed:17519354). {ECO:0000269|PubMed:12434153, ECO:0000269|PubMed:14759371, ECO:0000269|PubMed:17099699, ECO:0000269|PubMed:17519354, ECO:0000269|PubMed:28801535}.
uniprot
proteins
mass_dalton
178702
uniprot
proteins
mutagenesis
MUTAGEN 1..128; /note="Missing: Abolishes interaction with the CHRAC1-POLE3 heterodimer."; /evidence="ECO:0000269|PubMed:14759371"; MUTAGEN 667..933; /note="Missing: Abolishes interaction with SMARCA5/SNF2H, and abolishes the formation of the CHRACISWI chromatin remodeling complex."; /evidence="ECO:0000269|PubMed:12434153
uniprot
proteins
protein_family
WAL family
uniprot
proteins
pubmed
10655480
uniprot
proteins
pubmed
10662543
uniprot
proteins
pubmed
10880450
uniprot
proteins
pubmed
12198550
uniprot
proteins
pubmed
12434153
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14759371
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17099699
uniprot
proteins
pubmed
17519354
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25593309
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28801535
uniprot
proteins
sequence_length
1556
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10880450, ECO:0000269|PubMed:25593309}. Note=Localizes to pericentric heterochromatin (By similarity). May target the CHRAC complex to heterochromatin (PubMed:10880450). Localizes to sites of DNA damage (PubMed:25593309). {ECO:0000250|UniProtKB:O88379, ECO:0000269|PubMed:10880450, ECO:0000269|PubMed:25593309}.
uniprot
proteins