Ptges3
entrez
56351
canonical
uniprot
Q9R0Q7
canonical
ensembl
ENSMUSG00000071072
resolver
ensp
ENSMUSP00000050292
resolver
enst
ENSMUST00000052798
resolver
genesymbol
Ptges3
resolver
genesymbol_syn
Sid3177
resolver
genesymbol_syn
Tebp
resolver
uniprot
Q542V4
resolver
uniprot
Q9D7V0
resolver
uniprot
Q9WV83
resolver
uniprot_entry
TEBP_MOUSE
resolver
uniprot_sec
Q542V4
resolver
uniprot_sec
Q9D7V0
resolver
uniprot_sec
Q9WV83
resolver
amino_acid_sequence
MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLFHCIDPNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDEDMSNFDRFSEMMDHMGGDEDVDLPEVDGADDDSQDSDDEKMPDLE
uniprot
proteins
ec_number
5.3.99.3
uniprot
proteins
function
FUNCTION: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes. Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway. {ECO:0000250|UniProtKB:Q15185}.
uniprot
proteins
mass_dalton
18721
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; prostaglandin biosynthesis. {ECO:0000250|UniProtKB:Q15185}.
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved by caspase-7 (CASP7) in response to apoptosis, leading to its inactivation. {ECO:0000250|UniProtKB:Q15185}.
uniprot
proteins
protein_family
P23/wos2 family
uniprot
proteins
pubmed
14563409
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15378723
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
160
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q3ZBF7}.
uniprot
proteins