Smyd4
entrez
319822
canonical
uniprot
Q8BTK5
canonical
ensembl
ENSMUSG00000018809
resolver
ensp
ENSMUSP00000047505
resolver
ensp
ENSMUSP00000302425
resolver
genesymbol
Smyd4
resolver
genesymbol_syn
Kiaa1936
resolver
uniprot
A2BDD0
resolver
uniprot
Q3U3Z8
resolver
uniprot
Q501N5
resolver
uniprot
Q5SWN4
resolver
uniprot
Q69Z60
resolver
uniprot
Q8BMP3
resolver
uniprot_entry
SMYD4_MOUSE
resolver
uniprot_sec
A2BDD0
resolver
uniprot_sec
Q3U3Z8
resolver
uniprot_sec
Q501N5
resolver
uniprot_sec
Q5SWN4
resolver
uniprot_sec
Q69Z60
resolver
uniprot_sec
Q8BMP3
resolver
amino_acid_sequence
MDLPVDEWKSYLLKKWASLPKSVQDTISTAETLSDIFLPSSSLLQPEDEMFLKELSSSYSVEKDNDAPLFYREEGNRKFQEKEYTDAAVLYSKGVSHSRPNTEDISLCYANRSAALFHLGQYEACLKDIVEAGMHGYPERLQPKMMVRKTECLVNLGRLQEARQTISDLESSLTAKPTLVLSSYQILQRNVQHLKIKIQEKETLPEPIPAALTNAFEDIALGEENTQISGASLSVSLCTHPLKGRHLVATKDILPGELLVKEDAFVSVLIPGEMPRPHHCLENKWDTRVTSGDLYCHRCLKHTLATVPCGSCSYAKYCSQECMQQAWDLYHSTECSLGGLLLTLGVFCHVALRMTLLARFEDVDRVVRMLCDEVGSTDTCLPESKNLVKAFDYTSQGESEEKSKIGEPPIPGCNVNGKYGSNYNAIFSLLPHTEKHSPEHRFICAISVSALCRQLKADSVQAQTLKSPKLKAVTPGLCADLTVWGAAMLRHMLQLQCNAQAITSICHTGSNESIITNSRQIRLATGIFPVVSLLNHSCRPNTSVSFTGTVATVRAAQRIAKGQEILHCYGPHESRMGVAERQQRLSSQYFFDCRCGACHAETLRAAAAPRWEAFCCKTCRALMQGNDVLSCSNESCTNSVSRDQLVSRLQDLQQQVCMAQKLLRTGKPEQAIQQLLRCREAAESFLSAEHTVLGEIEDGLAQAHATLGNWLKSAAHVQKSLQVVETRHGPSSVEIGHELFKLAQVLFNGLAVPEALSAIWKAERILLVHCGPESEEVRELREMRSCLLDSSFVPVGPLV
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Protein-lysine N-methyltransferase. Monomethylates PRMT5, modulating its transcriptional activity (By similarity). May also act as a histone methyltransferase (By similarity). Plays a critical role in cardiac development. Acts as a key epigenetic regulator of gene expression during cardiac development via its dual activities as a methyltransferase and negative regulator of HDAC1 (By similarity). {ECO:0000250|UniProtKB:Q08C84, ECO:0000250|UniProtKB:Q8IYR2}.
uniprot
proteins
mass_dalton
88538
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
30110327
uniprot
proteins
sequence_length
799
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:30110327}. Cytoplasm {ECO:0000269|PubMed:30110327}.
uniprot
proteins