Cth
entrez
24962
canonical
uniprot
P18757
canonical
ensembl
ENSRNOG00000010658
resolver
ensp
ENSRNOP00000058914
resolver
enst
ENSRNOT00000067843
resolver
genesymbol
Cth
resolver
genesymbol_syn
CSE
resolver
uniprot
F7EXI5
resolver
uniprot
Q9EQS4
resolver
uniprot_entry
CGL_RAT
resolver
uniprot_entry
F7EXI5_RAT
resolver
uniprot_entry
Q9EQS4_RAT
resolver
amino_acid_sequence
MQKDASSSGFLPSFQHFATQAIHVGPEPEQWSSRAVVLPISLATTFKQDSPGQSSGFVYSRSGNPTRNCLEKAVAALDGAKHCLTFARGLAATTTITHLLKAGDEVICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIKACAQIVHKHKDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVTSDDLNERLRFLQNSLGAVPSPFDCYLCCRGLKTLQIRMEKHFRNGMAVARFLESNPRVEKVIYPGLPSHPQHELAKRQCTGCPGMVSFYIKGTLQHAQVFLKNIKLFALAESLGGYESLAELPAIMTHASVPEKDRATLGISDTLIRLSVGLEDEKDLLEDLGQALKAAHP
uniprot
proteins
ec_number
4.4.1.1
uniprot
proteins
ec_number
4.4.1.2
uniprot
proteins
function
FUNCTION: Catalyzes the last step in the trans-sulfuration pathway from L-methionine to L-cysteine in a pyridoxal-5'-phosphate (PLP)-dependent manner, which consists on cleaving the L,L-cystathionine molecule into L-cysteine, ammonia and 2-oxobutanoate (Probable) (PubMed:13525371). Part of the L-cysteine derived from the trans-sulfuration pathway is utilized for biosynthesis of the ubiquitous antioxidant glutathione. Besides its role in the conversion of L-cystathionine into L-cysteine, it utilizes L-cysteine and L-homocysteine as substrates (at much lower rates than L,L-cystathionine) to produce hydrogen sulfide (H2S). In vitro, it converts two L-cysteine molecules into lanthionine and H2S, and two L-homocysteine molecules to homolanthionine and H2S, which can be particularly relevant under conditions of severe hyperhomocysteinemia. Lanthionine and homolanthionine are structural homologs of L,L-cystathionine that differ by the absence or presence of an extra methylene group, respectively. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function. By generating the gasotransmitter H2S, it participates in a number of physiological processes such as vasodilation, bone protection, and inflammation (By similarity). Plays an essential role in myogenesis by contributing to the biogenesis of H2S in skeletal muscle tissue (By similarity). Can also accept homoserine as substrate (PubMed:13525371). Catalyzes the elimination of selenocystathionine (which can be derived from the diet) to yield selenocysteine, ammonia and 2-oxobutanoate (Probable). {ECO:0000250|UniProtKB:P32929, ECO:0000250|UniProtKB:Q8VCN5, ECO:0000269|PubMed:13525371, ECO:0000305|PubMed:6456763}.
uniprot
proteins
mass_dalton
43605
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2. {ECO:0000305|PubMed:13525371}.
uniprot
proteins
protein_family
Trans-sulfuration enzymes family
uniprot
proteins
pubmed
13525371
uniprot
proteins
pubmed
2201285
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
6456763
uniprot
proteins
pubmed
8288556
uniprot
proteins
sequence_length
398
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins