SLC29A4
entrez
222962
canonical
uniprot
Q7RTT9
canonical
ensembl
ENSG00000164638
resolver
ensp
ENSP00000297195
resolver
ensp
ENSP00000380081
resolver
ensp
ENSP00000385845
resolver
genesymbol
SLC29A4
resolver
genesymbol_syn
ENT4
resolver
genesymbol_syn
PMAT
resolver
hgnc
HGNC:23097
resolver
uniprot
Q6PJ08
resolver
uniprot
Q86WY8
resolver
uniprot
Q8NAR3
resolver
uniprot
Q8NBM2
resolver
uniprot_entry
S29A4_HUMAN
resolver
uniprot_sec
Q6PJ08
resolver
uniprot_sec
Q86WY8
resolver
uniprot_sec
Q8NAR3
resolver
uniprot_sec
Q8NBM2
resolver
activity_regulation
ACTIVITY REGULATION: Activated at acidic pH. {ECO:0000269|PubMed:16873718, ECO:0000269|PubMed:17018840, ECO:0000269|PubMed:20592246, ECO:0000269|PubMed:22396231, ECO:0000269|PubMed:31537831}.
uniprot
proteins
amino_acid_sequence
MGSVGSQRLEEPSVAGTPDPGVVMSFTFDSHQLEEAAEAAQGQGLRARGVPAFTDTTLDEPVPDDRYHAIYFAMLLAGVGFLLPYNSFITDVDYLHHKYPGTSIVFDMSLTYILVALAAVLLNNVLVERLTLHTRITAGYLLALGPLLFISICDVWLQLFSRDQAYAINLAAVGTVAFGCTVQQSSFYGYTGMLPKRYTQGVMTGESTAGVMISLSRILTKLLLPDERASTLIFFLVSVALELLCFLLHLLVRRSRFVLFYTTRPRDSHRGRPGLGRGYGYRVHHDVVAGDVHFEHPAPALAPNESPKDSPAHEVTGSGGAYMRFDVPRPRVQRSWPTFRALLLHRYVVARVIWADMLSIAVTYFITLCLFPGLESEIRHCILGEWLPILIMAVFNLSDFVGKILAALPVDWRGTHLLACSCLRVVFIPLFILCVYPSGMPALRHPAWPCIFSLLMGISNGYFGSVPMILAAGKVSPKQRELAGNTMTVSYMSGLTLGSAVAYCTYSLTRDAHGSCLHASTANGSILAGL
uniprot
proteins
function
FUNCTION: Electrogenic voltage-dependent transporter that mediates the transport of a variety of endogenous bioactive amines, cationic xenobiotics and drugs (PubMed:15448143, PubMed:16099839, PubMed:16873718, PubMed:17018840, PubMed:17121826, PubMed:20592246, PubMed:20858707, PubMed:22396231, PubMed:31537831). Utilizes the physiologic inside-negative membrane potential as a driving force to facilitate cellular uptake of organic cations (PubMed:15448143, PubMed:20592246, PubMed:22396231). Functions as a Na(+)- and Cl(-)-independent bidirectional transporter (PubMed:15448143, PubMed:16099839, PubMed:22396231, PubMed:31537831). Substrate transport is pH-dependent and enhanced under acidic condition, which is most likely the result of allosteric changes in the transporter structure (PubMed:16873718, PubMed:17018840, PubMed:20592246, PubMed:22396231, PubMed:31537831). Implicated in monoamine neurotransmitters uptake such as serotonin, dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the central nervous system (PubMed:15448143, PubMed:16099839, PubMed:17018840, PubMed:17121826, PubMed:20858707, PubMed:22396231). Also responsible for the uptake of bioactive amines and drugs through the blood-cerebrospinal fluid (CSF) barrier, from the CSF into choroid plexus epithelial cells, thereby playing a significant role in the clearance of cationic neurotoxins, xenobiotics and metabolic waste in the brain (By similarity). Involved in bidirectional transport of the purine nucleoside adenosine and plays a role in the regulation of extracellular adenosine concentrations in cardiac tissues, in particular during ischemia (PubMed:16873718, PubMed:20592246, PubMed:31537831). May be involved in organic cation uptake from the tubular lumen into renal tubular cells, thereby contributing to organic cation reabsorption in the kidney (PubMed:17018840). Also transports guanidine (PubMed:16099839). {ECO:0000250|UniProtKB:Q8R139, ECO:0000269|PubMed:15448143, ECO:0000269|PubMed:16099839, ECO:0000269|PubMed:16873718, ECO:0000269|PubMed:17018840, ECO:0000269|PubMed:17121826, ECO:0000269|PubMed:20592246, ECO:0000269|PubMed:20858707, ECO:0000269|PubMed:22396231, ECO:0000269|PubMed:31537831}.
uniprot
proteins
mass_dalton
58059
uniprot
proteins
mutagenesis
MUTAGEN 91; /note="D->A: No significant change in dopamine, serotonin and MPP(+) uptake."; /evidence="ECO:0000269|PubMed:17121826"; MUTAGEN 107; /note="D->A: Loss of dopamine, serotonin and MPP(+) uptake."; /evidence="ECO:0000269|PubMed:17121826"; MUTAGEN 128; /note="E->A: No significant change in dopamine, serotonin and MPP(+) uptake."; /evidence="ECO:0000269|PubMed:17121826"; MUTAGEN 154; /note="D->A: Loss of dopamine, serotonin and MPP(+) uptake; increased uridine uptake."; /evidence="ECO:0000269|PubMed:17121826"; MUTAGEN 163; /note="D->A: Loss of dopamine, serotonin and MPP(+) uptake."; /evidence="ECO:0000269|PubMed:17121826"; MUTAGEN 206; /note="E->A: Loss of dopamine, serotonin and MPP(+) uptake; gain of uridine transport activity."; /evidence="ECO:0000269|PubMed:17121826"; MUTAGEN 206; /note="E->D: No change in dopamine, serotonin and MPP(+) uptake; no uridine uptake activity."; /evidence="ECO:0000269|PubMed:17121826"; MUTAGEN 206; /note="E->Q: Loss of dopamine, serotonin, adenosine and MPP(+) uptake; gain of uridine transport activity."; /evidence="ECO:0000269|PubMed:16873718, ECO:0000269|PubMed:17121826"; MUTAGEN 206; /note="E->R: Loss of dopamine, serotonin and MPP(+) uptake; no uridine uptake activity."; /evidence="ECO:0000269|PubMed:17121826"; MUTAGEN 220; /note="T->A: Reduced dopamine, serotonin and MPP(+) uptake."; /evidence="ECO:0000269|PubMed:17121826"; MUTAGEN 220; /note="T->I: Loss of dopamine, serotonin and MPP(+) uptake."; /evidence="ECO:0000269|PubMed:17121826"; MUTAGEN 220; /note="T->S: Reduced dopamine, serotonin and MPP(+) uptake."; /evidence="ECO:0000269|PubMed:17121826"; MUTAGEN 227; /note="E->A: Functional with slight increased dopamine, serotonin and MPP(+) uptake."; /evidence="ECO:0000269|PubMed:17121826"; MUTAGEN 242; /note="E->A: Reduced dopamine, serotonin and MPP(+) uptake."; /evidence="ECO:0000269|PubMed:17121826"; MUTAGEN 336; /note="W->A: Loss of dopamine, serotonin and MPP(+) uptake."; /evidence="ECO:0000269|PubMed:17121826"; MUTAGEN 375; /note="E->A: Functional with increased dopamine, serotonin and MPP(+) uptake."; /evidence="ECO:0000269|PubMed:17121826"; MUTAGEN 375; /note="E->Q: No change in adenosine uptake."; /evidence="ECO:0000269|PubMed:16873718
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:16873718}.
uniprot
proteins
protein_family
SLC29A/ENT transporter (TC 2.A.57) family
uniprot
proteins
pubmed
12446811
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15448143
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16099839
uniprot
proteins
pubmed
16873718
uniprot
proteins
pubmed
17018840
uniprot
proteins
pubmed
17121826
uniprot
proteins
pubmed
17393420
uniprot
proteins
pubmed
20592246
uniprot
proteins
pubmed
20858707
uniprot
proteins
pubmed
22396231
uniprot
proteins
pubmed
23255610
uniprot
proteins
pubmed
31537831
uniprot
proteins
sequence_length
530
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15448143, ECO:0000269|PubMed:16873718, ECO:0000269|PubMed:17121826, ECO:0000269|PubMed:20858707}; Multi-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:17018840, ECO:0000269|PubMed:23255610}; Multi-pass membrane protein {ECO:0000305}. Note=Located to the plasma membranes of ventricular myocytes and vascular endothelial cells (PubMed:16873718). Targeted to the apical membranes of differentiated kidney epithelial cells (PubMed:17018840). Localized to the apical blood-cerebrospinal fluid (CSF)-facing membrane of the choroid plexus epithelium (PubMed:23255610). {ECO:0000269|PubMed:16873718, ECO:0000269|PubMed:17018840, ECO:0000269|PubMed:23255610}.
uniprot
proteins
transmembrane_region
TRANSMEM 69..89; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 102..122; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 140..160; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 167..187; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 232..252; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 352..372; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 382..402; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 417..437; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 451..471; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 487..509; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins