Sharpin
entrez
81859
canonical
uniprot
Q9EQL9
canonical
ensembl
ENSRNOG00000012812
resolver
ensembl
ENSRNOG00055026109
resolver
ensembl
ENSRNOG00060024484
resolver
ensembl
ENSRNOG00065001639
resolver
ensembl
ENSRNOG00065009872
resolver
ensp
ENSRNOP00000018032
resolver
ensp
ENSRNOP00055036965
resolver
ensp
ENSRNOP00060035131
resolver
ensp
ENSRNOP00065001547
resolver
ensp
ENSRNOP00065011999
resolver
enst
ENSRNOT00000018031
resolver
enst
ENSRNOT00055045068
resolver
enst
ENSRNOT00060042396
resolver
enst
ENSRNOT00065002204
resolver
enst
ENSRNOT00065015871
resolver
genesymbol
Sharpin
resolver
uniprot_entry
SHRPN_RAT
resolver
amino_acid_sequence
MSPPAGGAAAAADPASPVVLLAVQAAVRLLGAGHEDEAQLRKLQLKADPERPGRFRLGLLGIEPGAVSLEWPLESICYTIRGPNQHELQPPPGGPGTFSVHFLNSEEAQQWAALVRDATAEGQNGNDSTAPVPTPAMCPTSPPCSSVTPTPKATQPEMDLPQGSGNLKKEELATHLAQAIAGGDEKAAAQVAAILAQHHVALNVQLLEAWFPRGPIRLQVTVEDATSVLSSSSSAHVSLQIHPHCSIAALQEQVFSEFGFPPAVQRWVIGRCLCMPERSLASYGVSQDGDPAFLYLLSAPREVSGHSPQHSKMDRKLGCLFPQSLELPHNLQASSSSLPSPPQPGWSCPSCTFINASNRPGCEMCSTQRPCAWDPLTATST
uniprot
proteins
function
FUNCTION: Component of the LUBAC complex which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria. LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin. The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation. Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. {ECO:0000250|UniProtKB:Q9H0F6}.
uniprot
proteins
mass_dalton
40287
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9H0F6}.
uniprot
proteins
pubmed
11178875
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23897824
uniprot
proteins
sequence_length
381
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11178875}. Synapse {ECO:0000269|PubMed:11178875}. Note=Enriched at synaptic sites in mature neurons where it colocalizes with SHANK1. {ECO:0000269|PubMed:11178875}.
uniprot
proteins