SUMO3
entrez
6612
canonical
uniprot
P55854
canonical
ensembl
ENSG00000184900
resolver
ensp
ENSP00000330343
resolver
ensp
ENSP00000409666
resolver
genesymbol
SUMO3
resolver
genesymbol_syn
SMT3A
resolver
genesymbol_syn
SMT3H1
resolver
hgnc
HGNC:11124
resolver
uniprot
B2R5X4
resolver
uniprot
B4DUW4
resolver
uniprot
Q53HI9
resolver
uniprot
Q6FGD4
resolver
uniprot
Q9BWR4
resolver
uniprot_entry
SUMO3_HUMAN
resolver
uniprot_sec
B2R5X4
resolver
uniprot_sec
B4DUW4
resolver
uniprot_sec
Q53HI9
resolver
uniprot_sec
Q6FGD4
resolver
uniprot_sec
Q9BWR4
resolver
amino_acid_sequence
MSEEKPKEGVKTENDHINLKVAGQDGSVVQFKIKRHTPLSKLMKAYCERQGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGGVPESSLAGHSF
uniprot
proteins
function
FUNCTION: Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744). {ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:21965678}.
uniprot
proteins
mass_dalton
11637
uniprot
proteins
mutagenesis
MUTAGEN 11; /note="K->R: Abolishes the formation of poly(SUMO) chains."; /evidence="ECO:0000269|PubMed:11451954"; MUTAGEN 33; /note="I->A: Impaired interaction with USP25; when associated with A-34."; /evidence="ECO:0000269|PubMed:18538659"; MUTAGEN 34; /note="K->A: Impaired interaction with USP25; when associated with A-33."; /evidence="ECO:0000269|PubMed:18538659
uniprot
proteins
post_translational_modification
PTM: Polymeric chains can be formed through Lys-11 cross-linking.; PTM: Cleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function. {ECO:0000269|PubMed:15487983, ECO:0000269|PubMed:16608850}.
uniprot
proteins
protein_family
SUMO subfamily
uniprot
proteins
protein_family
Ubiquitin family
uniprot
proteins
pubmed
10692421
uniprot
proteins
pubmed
10830953
uniprot
proteins
pubmed
11451954
uniprot
proteins
pubmed
12383504
uniprot
proteins
pubmed
12924945
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15296745
uniprot
proteins
pubmed
15487983
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15723523
uniprot
proteins
pubmed
16553580
uniprot
proteins
pubmed
16608850
uniprot
proteins
pubmed
18538659
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21965678
uniprot
proteins
pubmed
24105744
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
9119407
uniprot
proteins
sequence_length
103
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus, PML body {ECO:0000250}.
uniprot
proteins