Atat1
entrez
361789
canonical
uniprot
Q6MG11
canonical
ensembl
ENSRNOG00000000809
resolver
ensp
ENSRNOP00000001077
resolver
ensp
ENSRNOP00000098195
resolver
ensp
ENSRNOP00000111683
resolver
ensp
ENSRNOP00000112539
resolver
enst
ENSRNOT00000001077
resolver
enst
ENSRNOT00000080158
resolver
enst
ENSRNOT00000120554
resolver
genesymbol
Atat1
resolver
genesymbol_syn
ATAT1
resolver
genesymbol_syn
MEC17
resolver
genesymbol_syn
Mec17
resolver
uniprot
A0ABK0M766
resolver
uniprot
A0ABK0M8S8
resolver
uniprot
G3V628
resolver
uniprot_entry
A0ABK0M766_RAT
resolver
uniprot_entry
A0ABK0M8S8_RAT
resolver
uniprot_entry
ATAT_RAT
resolver
uniprot_entry
G3V628_RAT
resolver
amino_acid_sequence
MEFPFDVDALFPERITVLDQHLRPPARRPGTTTPARVDLQQQIMTIVDELGKASAKAQHLPAPITSALRMQSNRHVIYVLKDTSARPAGKGAIIGFLKVGYKKLFVLDDREAHNEVEPLCILDFYIHESVQRHGHGRELFQYMLQKERVEPHQLAIDRPSPKLLKFLNKHYNLETTVPQVNNFVIFEGFFAHQHRSPTPSLRATRHSRAAVVDPIPAAPARKLPPKRAEGDIKPYSSSDREFLKVAVEPPWPLNRAPRRATPPAHPPPRSSSLGNSPDRGPLRPFVPEQELLRSLRLCPPHPTARLLLATDPGGSPAQRRRTRETPWGLVAQSCHYSRHGGFNTSFLGTGNQERKQGEQEAEDRSASEDQVLLQDGSGEEPTHTVAPRAQAPPAQSWMVGGDILNARVIRNLQERRNTRPW
uniprot
proteins
ec_number
2.3.1.108
uniprot
proteins
function
FUNCTION: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. {ECO:0000255|HAMAP-Rule:MF_03130}.
uniprot
proteins
mass_dalton
47327
uniprot
proteins
post_translational_modification
PTM: Autoacetylation strongly increases tubulin acetylation. {ECO:0000255|HAMAP-Rule:MF_03130}.
uniprot
proteins
protein_family
Acetyltransferase ATAT1 family
uniprot
proteins
pubmed
15060004
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
421
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03130}. Membrane, clathrin-coated pit {ECO:0000255|HAMAP-Rule:MF_03130}. Cell junction, focal adhesion {ECO:0000255|HAMAP-Rule:MF_03130}. Cell projection, axon {ECO:0000255|HAMAP-Rule:MF_03130}. Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03130}. Cytoplasm, cytoskeleton, spindle {ECO:0000255|HAMAP-Rule:MF_03130}.
uniprot
proteins