Ccdc61
entrez
292680
canonical
uniprot
A0JPP8
canonical
ensembl
ENSRNOG00000013767
resolver
ensp
ENSRNOP00000018495
resolver
genesymbol
Ccdc61
resolver
genesymbol_syn
VFL3
resolver
uniprot_entry
CCD61_RAT
resolver
amino_acid_sequence
MEQPAGLQVDYMFRGVEHAVRVVVSGQVLELEVEDRMTADQWRGEFDANFIEDLTHKTGNFKQFSIFCNMLESALTQSSESVTLDLLTYTDLESLRSRKLGGRPGPCPRSAQLNSKRYLILIYSVEFDRIHYPLPLPYQGKPDPVVLQGIIRSLKEELGHLRGMNGGQDARETEIWHLREQVTRLASEKRELEAQLGRSREEALAGRAARQEAESLRGLVRGLELELRQERGLGGRAAGRRSQDCRRLAKELEEVKASERNLRARLKTLNCELAMYRRGRRTLPAGAREDRALSSRERSTSRGRTATRSSSRESNRGARSHGRPAHPSPSPTGSRVPRFDPTAFVKAKEKKQREIRMKRQQQQQQQRNRMGSGGSGDGPSVSWSHQTRPPAAVTGRGDAANRSRNRSSSVDSFRSRCSSVSSCSELEDFSQSVSKSRRCRGRGKPPSPIPWSGSKTKSTTRERNNHQRHLASSGAWVPIKEYSSDYQGADMAEIDARLKALQEYMNRLDTRS
uniprot
proteins
function
FUNCTION: Microtubule-binding centrosomal protein required for centriole cohesion, independently of the centrosome-associated protein/CEP250 and rootletin/CROCC linker. In interphase, required for anchoring microtubule at the mother centriole subdistal appendages and for centrosome positioning. During mitosis, may be involved in spindle assembly and chromatin alignment by regulating the organization of spindle microtubules into a symmetrical structure. Plays a non-essential role in ciliogenesis. {ECO:0000250|UniProtKB:Q9Y6R9}.
uniprot
proteins
mass_dalton
57730
uniprot
proteins
protein_family
CCDC61 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
512
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9Y6R9}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000250|UniProtKB:Q9Y6R9}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9Y6R9}. Note=Localization at the centriolar satellite is dependent on intact microtubule network. Localizes at the centriole subdistal appendages and proximal ends. Localized to centrosomal/satellite-like structures with the onset of centrosome separation in early G2. {ECO:0000250|UniProtKB:Q9Y6R9}.
uniprot
proteins