Hnrnpk
entrez
15387
canonical
uniprot
P61979
canonical
ensembl
ENSMUSG00000021546
resolver
ensp
ENSMUSP00000039269
resolver
ensp
ENSMUSP00000112104
resolver
ensp
ENSMUSP00000135354
resolver
ensp
ENSMUSP00000135647
resolver
ensp
ENSMUSP00000152935
resolver
ensp
ENSMUSP00000153253
resolver
ensp
ENSMUSP00000295229
resolver
ensp
ENSMUSP00000295233
resolver
ensp
ENSMUSP00000295271
resolver
ensp
ENSMUSP00000295283
resolver
ensp
ENSMUSP00000295285
resolver
ensp
ENSMUSP00000295287
resolver
ensp
ENSMUSP00000295298
resolver
enst
ENSMUST00000177019
resolver
genesymbol
Hnrnpk
resolver
genesymbol_syn
Hnrpk
resolver
uniprot
B2M1R6
resolver
uniprot
H3BL45
resolver
uniprot
Q07244
resolver
uniprot
Q15671
resolver
uniprot
Q3U9Q3
resolver
uniprot
Q5FWJ5
resolver
uniprot
Q60577
resolver
uniprot
Q8BGQ8
resolver
uniprot
Q922Y7
resolver
uniprot
Q96J62
resolver
uniprot_entry
B2M1R6_MOUSE
resolver
uniprot_entry
H3BL45_MOUSE
resolver
uniprot_entry
HNRPK_MOUSE
resolver
uniprot_entry
Q3U9Q3_MOUSE
resolver
uniprot_entry
Q5FWJ5_MOUSE
resolver
uniprot_sec
Q07244
resolver
uniprot_sec
Q15671
resolver
uniprot_sec
Q60577
resolver
uniprot_sec
Q8BGQ8
resolver
uniprot_sec
Q922Y7
resolver
uniprot_sec
Q96J62
resolver
amino_acid_sequence
METEQPEETFPNTETNGEFGKRPAEDMEEEQAFKRSRNTDEMVELRILLQSKNAGAVIGKGGKNIKALRTDYNASVSVPDSSGPERILSISADIETIGEILKKIIPTLEEGLQLPSPTATSQLPLESDAVECLNYQHYKGSDFDCELRLLIHQSLAGGIIGVKGAKIKELRENTQTTIKLFQECCPHSTDRVVLIGGKPDRVVECIKIILDLISESPIKGRAQPYDPNFYDETYDYGGFTMMFDDRRGRPVGFPMRGRGGFDRMPPGRGGRPMPPSRRDYDDMSPRRGPPPPPPGRGGRGGSRARNLPLPPPPPPRGGDLMAYDRRGRPGDRYDGMVGFSADETWDSAIDTWSPSEWQMAYEPQGGSGYDYSYAGGRGSYGDLGGPIITTQVTIPKDLAGSIIGKGGQRIKQIRHESGASIKIDEPLEGSEDRIITITGTQDQIQNAQYLLQNSVKQYSGKFF
uniprot
proteins
function
FUNCTION: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (By similarity). {ECO:0000250|UniProtKB:P61978, ECO:0000269|PubMed:20673990}.
uniprot
proteins
mass_dalton
50976
uniprot
proteins
post_translational_modification
PTM: Sumoylated by CBX4. Sumoylation is increased upon DNA damage, such as that produced by doxorubicin, etoposide, UV light and camptothecin, due to enhanced CBX4 phosphorylation by HIPK2 under these conditions (By similarity). {ECO:0000250|UniProtKB:P61978}.; PTM: Ubiquitinated by MDM2. Doxorubicin treatment does not affect monoubiquitination, but slightly decreases HNRNPK poly-ubiquitination (By similarity). {ECO:0000250|UniProtKB:P61978}.; PTM: O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. {ECO:0000250|UniProtKB:P61978}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16360036
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
20673990
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22570411
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
39389056
uniprot
proteins
pubmed
8021272
uniprot
proteins
pubmed
8910362
uniprot
proteins
sequence_length
463
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P61978}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:P61978}. Cell projection, podosome {ECO:0000250|UniProtKB:P61978}.
uniprot
proteins