Rab7b
entrez
226421
canonical
uniprot
Q8VEA8
canonical
ensembl
ENSMUSG00000052688
resolver
ensp
ENSMUSP00000065456
resolver
ensp
ENSMUSP00000066452
resolver
ensp
ENSMUSP00000208667
resolver
ensp
ENSMUSP00000208670
resolver
genesymbol
Rab7b
resolver
genesymbol_syn
5430435G22Rik
resolver
uniprot
J9UUF7
resolver
uniprot
Q0PD09
resolver
uniprot
Q8BJT0
resolver
uniprot
Q8BZB1
resolver
uniprot_entry
J9UUF7_MOUSE
resolver
uniprot_entry
RAB7B_MOUSE
resolver
uniprot_sec
Q0PD09
resolver
uniprot_sec
Q8BJT0
resolver
uniprot_sec
Q8BZB1
resolver
amino_acid_sequence
MNPRKKVDLKLIIVGALGVGKTSLLHQYVHKTFFEEYQTTLGASILSKIIILDDTTLKLQIWDTGGQERFRSMVSTFYKGSDGCILAFDVTDPESFEALDIWRDDVLAKIIPMEQSYPMVVLGNKIDLEDRKVSQEVVHGWCKEKDMPYFEVSAKNDINVVQAFEVLASRALLRYQGTAENHLIDSIKLSPGQPKSRCC
uniprot
proteins
function
FUNCTION: Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway. {ECO:0000269|PubMed:17395780, ECO:0000269|PubMed:19587007}.
uniprot
proteins
mass_dalton
22502
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16923123
uniprot
proteins
pubmed
17395780
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19587007
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
199
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome {ECO:0000269|PubMed:19587007}. Lysosome {ECO:0000269|PubMed:17395780, ECO:0000269|PubMed:19587007}. Golgi apparatus {ECO:0000250|UniProtKB:Q96AH8}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q96AH8}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q96AH8}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Recruited to phagosomes containing S.aureus or Mycobacterium. {ECO:0000250|UniProtKB:Q96AH8}.
uniprot
proteins