TOLLIP
entrez
54472
canonical
uniprot
Q9H0E2
canonical
ensembl
ENSG00000078902
resolver
ensembl
ENSG00000291426
resolver
ensp
ENSP00000314733
resolver
ensp
ENSP00000432668
resolver
ensp
ENSP00000432778
resolver
ensp
ENSP00000434035
resolver
ensp
ENSP00000434494
resolver
ensp
ENSP00000516892
resolver
ensp
ENSP00000516895
resolver
ensp
ENSP00000533495
resolver
ensp
ENSP00000776481
resolver
enst
ENST00000525159
resolver
enst
ENST00000527938
resolver
enst
ENST00000707521
resolver
enst
ENST00000707524
resolver
genesymbol
TOLLIP
resolver
hgnc
HGNC:16476
resolver
uniprot
B3KR28
resolver
uniprot
B3KXC6
resolver
uniprot
E9PNS3
resolver
uniprot
F2Z2Y8
resolver
uniprot
Q6FIE9
resolver
uniprot
Q8N8J5
resolver
uniprot
Q9H9E6
resolver
uniprot
Q9UJ69
resolver
uniprot_entry
B3KR28_HUMAN
resolver
uniprot_entry
E9PNS3_HUMAN
resolver
uniprot_entry
F2Z2Y8_HUMAN
resolver
uniprot_entry
Q6FIE9_HUMAN
resolver
uniprot_entry
Q8N8J5_HUMAN
resolver
uniprot_entry
TOLIP_HUMAN
resolver
uniprot_sec
B3KXC6
resolver
uniprot_sec
Q9H9E6
resolver
uniprot_sec
Q9UJ69
resolver
amino_acid_sequence
MATTVSTQRGPVYIGELPQDFLRITPTQQQRQVQLDAQAAQQLQYGGAVGTVGRLNITVVQAKLAKNYGMTRMDPYCRLRLGYAVYETPTAHNGAKNPRWNKVIHCTVPPGVDSFYLEIFDERAFSMDDRIAWTHITIPESLRQGKVEDKWYSLSGRQGDDKEGMINLVMSYALLPAAMVMPPQPVVLMPTVYQQGVGYVPITGMPAVCSPGMVPVALPPAAVNAQPRCSEEDLKAIQDMFPNMDQEVIRSVLEAQRGNKDAAINSLLQMGEEP
uniprot
proteins
function
FUNCTION: Component of the signaling pathway of IL-1 and Toll-like receptors (PubMed:10854325, PubMed:11751856). Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex (PubMed:10854325). Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates (PubMed:25042851). The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851). In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes (PubMed:15047686). Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P) (PubMed:26320582). {ECO:0000269|PubMed:10854325, ECO:0000269|PubMed:11751856, ECO:0000269|PubMed:15047686, ECO:0000269|PubMed:25042851, ECO:0000269|PubMed:26320582}.
uniprot
proteins
mass_dalton
30282
uniprot
proteins
mutagenesis
MUTAGEN 9; /note="R->A: Reduced interaction with TOM1; when associated with Ala-12."; /evidence="ECO:0000269|PubMed:26320582"; MUTAGEN 12; /note="V->A: Reduced interaction with TOM1; when associated with Ala-9."; /evidence="ECO:0000269|PubMed:26320582"; MUTAGEN 20; /note="D->A: Reduced interaction with TOM1; when associated with Ala-23."; /evidence="ECO:0000269|PubMed:26320582"; MUTAGEN 21; /note="F->A: Reduced interaction with TOM1."; /evidence="ECO:0000269|PubMed:26320582"; MUTAGEN 23; /note="R->A: Reduced interaction with TOM1; when associated with Ala-20."; /evidence="ECO:0000269|PubMed:26320582
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products.
uniprot
proteins
protein_family
Tollip family
uniprot
proteins
pubmed
10854325
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
11751856
uniprot
proteins
pubmed
14563850
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15047686
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16412388
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
25042851
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26282398
uniprot
proteins
pubmed
26320582
uniprot
proteins
pubmed
31263572
uniprot
proteins
pubmed
37926288
uniprot
proteins
sequence_length
274
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:31263572}. Endosome {ECO:0000269|PubMed:15047686, ECO:0000269|PubMed:31263572}. Early endosome {ECO:0000269|PubMed:15047686, ECO:0000269|PubMed:26320582}. Note=Localized to endo/exosomal vesicles. {ECO:0000269|PubMed:31263572}.
uniprot
proteins