Stx1a
entrez
20907
canonical
uniprot
O35526
canonical
ensembl
ENSMUSG00000007207
resolver
ensp
ENSMUSP00000005509
resolver
ensp
ENSMUSP00000312102
resolver
enst
ENSMUST00000005509
resolver
genesymbol
Stx1a
resolver
uniprot
Q497P1
resolver
uniprot
Q5D0A4
resolver
uniprot_entry
Q497P1_MOUSE
resolver
uniprot_entry
Q5D0A4_MOUSE
resolver
uniprot_entry
STX1A_MOUSE
resolver
amino_acid_sequence
MKDRTQELRTAKDSDDDDDVTVTVDRDRFMDEFFEQVEEIRGFIDKIAENVEEVKRKHSAILASPNPDEKTKEELEELMSDIKKTANKVRSKLKSIEQSIEQEEGLNRSSADLRIRKTQHSTLSRKFVEVMSEYNATQSDYRERCKGRIQRQLEITGRTTTSEELEDMLESGNPAIFASGIIMDSSISKQALSEIETRHSEIIKLETSIRELHDMFMDMAMLVESQGEMIDRIEYNVEHAVDYVERAVSDTKKAVKYQSKARRKKIMIIICCVILGIIIASTIGGIFG
uniprot
proteins
function
FUNCTION: Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis (PubMed:17502420, PubMed:28031464, PubMed:28596237). Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane. STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion. Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm (PubMed:12101244). Also plays an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1) (PubMed:17502420, PubMed:28031464, PubMed:28596237). {ECO:0000269|PubMed:12101244, ECO:0000269|PubMed:17502420, ECO:0000269|PubMed:28031464, ECO:0000269|PubMed:28596237}.
uniprot
proteins
mass_dalton
33054
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CK2. Phosphorylation at Ser-188 by DAPK1 significantly decreases its interaction with STXBP1 (By similarity). {ECO:0000250}.; PTM: Phosphorylated by CK2 (By similarity). Phosphorylation at Ser-188 by DAPK1 significantly decreases its interaction with STXBP1 (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q16623}.; PTM: Sumoylated, sumoylation is required for regulation of synaptic vesicle endocytosis. {ECO:0000250|UniProtKB:Q16623}.
uniprot
proteins
protein_family
Syntaxin family
uniprot
proteins
pubmed
12101244
uniprot
proteins
pubmed
15774481
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17055430
uniprot
proteins
pubmed
17296554
uniprot
proteins
pubmed
17502420
uniprot
proteins
pubmed
18760330
uniprot
proteins
pubmed
19196426
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21445306
uniprot
proteins
pubmed
21998599
uniprot
proteins
pubmed
23341457
uniprot
proteins
pubmed
28031464
uniprot
proteins
pubmed
28596237
uniprot
proteins
pubmed
28821673
uniprot
proteins
pubmed
29056747
uniprot
proteins
sequence_length
288
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:18760330}; Single-pass type IV membrane protein {ECO:0000269|PubMed:18760330}. Synapse, synaptosome {ECO:0000269|PubMed:18760330}. Cell membrane {ECO:0000250|UniProtKB:P32851}. Note=Colocalizes with KCNB1 at the cell membrane. {ECO:0000250|UniProtKB:P32851}.
uniprot
proteins
transmembrane_region
TRANSMEM 266..286; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins