DUSP1
entrez
1843
canonical
uniprot
P28562
canonical
ensembl
ENSG00000120129
resolver
ensp
ENSP00000239223
resolver
ensp
ENSP00000538148
resolver
ensp
ENSP00000538149
resolver
enst
ENST00000239223
resolver
enst
ENST00000868089
resolver
enst
ENST00000868090
resolver
genesymbol
DUSP1
resolver
genesymbol_syn
CL100
resolver
genesymbol_syn
MKP1
resolver
genesymbol_syn
PTPN10
resolver
genesymbol_syn
VH1
resolver
hgnc
HGNC:3064
resolver
uniprot
B4DU40
resolver
uniprot
D3DQL9
resolver
uniprot
Q2V508
resolver
uniprot_entry
B4DU40_HUMAN
resolver
uniprot_entry
DUS1_HUMAN
resolver
uniprot_sec
D3DQL9
resolver
uniprot_sec
Q2V508
resolver
amino_acid_sequence
MVMEVGTLDAGGLRALLGERAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKGAMGLEHIVPNAELRGRLLAGAYHAVVLLDERSAALDGAKRDGTLALAAGALCREARAAQVFFLKGGYEAFSASCPELCSKQSTPMGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILPFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKNAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHSTNSALSYLQSPITTSPSC
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle. {ECO:0000250|UniProtKB:P28563}.
uniprot
proteins
mass_dalton
39298
uniprot
proteins
mutagenesis
MUTAGEN 258; /note="C->S: Loss of phosphatase activity."; /evidence="ECO:0000305|PubMed:29052270
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation. {ECO:0000250|UniProtKB:P28563}.; PTM: 'Lys-48'-linked polyubiquitinated by NEURL3, leading to proteasomal degradation. {ECO:0000269|PubMed:38667302}.
uniprot
proteins
protein_family
Non-receptor class dual specificity subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
1406996
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
29052270
uniprot
proteins
pubmed
38667302
uniprot
proteins
pubmed
8106404
uniprot
proteins
sequence_length
367
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q91790}.
uniprot
proteins