Mif
entrez
81683
canonical
uniprot
P30904
canonical
ensembl
ENSRNOG00055020944
resolver
ensembl
ENSRNOG00060024227
resolver
ensembl
ENSRNOG00065024727
resolver
ensp
ENSRNOP00055029006
resolver
ensp
ENSRNOP00060034770
resolver
ensp
ENSRNOP00065034720
resolver
enst
ENSRNOT00055035750
resolver
enst
ENSRNOT00060041926
resolver
enst
ENSRNOT00065042436
resolver
genesymbol
Mif
resolver
uniprot_entry
MIF_RAT
resolver
amino_acid_sequence
MPMFIVNTNVPRASVPEGFLSELTQQLAQATGKPAQYIAVHVVPDQLMTFSGTSDPCALCSLHSIGKIGGAQNRNYSKLLCGLLSDRLHISPDRVYINYYDMNAANVGWNGSTFA
uniprot
proteins
ec_number
5.3.2.1
uniprot
proteins
ec_number
5.3.3.12
uniprot
proteins
function
FUNCTION: Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity. {ECO:0000250|UniProtKB:P14174}.
uniprot
proteins
mass_dalton
12477
uniprot
proteins
protein_family
MIF family
uniprot
proteins
pubmed
1436109
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7951062
uniprot
proteins
pubmed
8605628
uniprot
proteins
sequence_length
115
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P14174}. Cytoplasm {ECO:0000250|UniProtKB:P14174}. Note=Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens. {ECO:0000250|UniProtKB:P14174}.
uniprot
proteins