Kcnk18
entrez
445371
canonical
uniprot
Q6Q1P3
canonical
ensembl
ENSRNOG00000032706
resolver
ensembl
ENSRNOG00055029139
resolver
ensembl
ENSRNOG00060000055
resolver
ensp
ENSRNOP00000039866
resolver
ensp
ENSRNOP00000060711
resolver
ensp
ENSRNOP00055041559
resolver
ensp
ENSRNOP00060000045
resolver
enst
ENSRNOT00000042977
resolver
enst
ENSRNOT00000064022
resolver
enst
ENSRNOT00055050475
resolver
enst
ENSRNOT00060000078
resolver
genesymbol
Kcnk18
resolver
genesymbol_syn
Tresk-2
resolver
genesymbol_syn
Tresk2
resolver
uniprot
B5L2C1
resolver
uniprot
F7F5U9
resolver
uniprot_entry
B5L2C1_RAT
resolver
uniprot_entry
F7F5U9_RAT
resolver
uniprot_entry
KCNKI_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by volatile anesthetics, such as isoflurane and inhibited by local anesthetics such as bupivacaine and lidocaine. Inhibited by extracellular acidic pH (PubMed:16192517). Inhibited by Zn(2+) ions (PubMed:16192517). {ECO:0000269|PubMed:16192517}.
uniprot
proteins
amino_acid_sequence
MEAEEPPEARRRCPEALGKASGCCPEAPGKARGCCPEALGKLLPGLCFLCCLVTYALVGAALFSAVEGRPDPEAEENPELKKFLDKLCNILKCNLTVVEGSRKDLCEHLQQLKPQWFKAPEDWSFLSALFFCCTVFSTVGYGHMYPVTRLGKFLCMLYALFGIPLMFLVLTDIGDILAAILSRAYSRFQALLCLPRDISKWRPLLLCRKQTDSKPADEAIPQIVIDAGADELLDPQPSREPASPSCNVELFERLVAREKQNELQPPMRPVERSNSCPELVLGRLSCSILSNLDEVGQQVERLDIPLPVIALVIFAYISCAAAILPFWETDLGFEDAFYFCFVTLTTIGFGDIVLVHPHFFLFFSIYIIVGMEILFIAFKLMQNRLLHTYKTLMLFVCQREVSLPC
uniprot
proteins
function
FUNCTION: K(+) channel that conducts outward and inward rectifying currents at depolarized and hyperpolarized membrane potentials, respectively. The outward rectifying currents are voltage-dependent, coupled to K(+) electrochemical gradient across the membrane, whereas the inward currents can be induced in response to activation of Ca(2+)-mobilizing receptors (PubMed:16192517). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (By similarity). In trigeminal ganglia sensory neurons, the heterodimers of KCNK18/TRESK and KCNK2/TREK-1 or KCNK10/TREK-2 inhibit neuronal firing and neurogenic inflammation by stabilizing the resting membrane potential at K(+) equilibrium potential as well as by regulating the threshold of action potentials and the spike frequency (By similarity). In thymocytes, conducts K(+) currents upon T cell receptor (TCR) signaling leading to sustained Ca(2+) influx and NF-kappa-B activation, FOXP3 transcription and positive selection of regulatory T cell (Treg) progenitor subsets (By similarity). Appears to mediate the analgesics effects of hydroxy-alpha-sanshool, a metabolite naturally present in Schezuan pepper and other Xanthoxylum plants (By similarity). {ECO:0000250|UniProtKB:Q6VV64, ECO:0000269|PubMed:16192517}.
uniprot
proteins
mass_dalton
45351
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Ser-275 is required for the binding of 14-3-3eta/YWHAH. Calcineurin-mediated dephosphorylation of Ser-287 enhances channel activity. {ECO:0000250|UniProtKB:Q6VV64}.; PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q6VV64}.
uniprot
proteins
protein_family
Two pore domain potassium channel (TC 1.A.1.8) family
uniprot
proteins
pubmed
16192517
uniprot
proteins
sequence_length
405
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 43..63; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 153..173; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 304..324; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 358..378; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins