D3ZWT9
uniprot
D3ZWT9
canonical
amino_acid_sequence
MVQERHPQRKGVCWTLRLWSTAVISMLLLSTCFIASCMVTYQFTMEKPNRRLSELHTYHSSLTCCSKGTMVSEKLWGCCPNHWKSFGSSCYLISTKENFWSISEQNYIHMGAHLVVINTETEQNYIIHQLNESLSYFLGLSDPQGNSKWQWIDNTPYPNNIKFWHPHEPNLPEEWCASIVYWNPSKWGWNDVFCDSKHNSICETKKIYL
uniprot
proteins
function
FUNCTION: Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas (By similarity). Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (By similarity). Also recognizes, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses (By similarity). {ECO:0000250|UniProtKB:Q6EIG7, ECO:0000250|UniProtKB:Q9JKF4}.
uniprot
proteins
mass_dalton
24555
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
209
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6EIG7}; Single-pass type II membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..43; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins