Ciapin1
entrez
307649
canonical
uniprot
Q5XID1
canonical
ensembl
ENSRNOG00000016234
resolver
ensp
ENSRNOP00000021769
resolver
ensp
ENSRNOP00000106580
resolver
enst
ENSRNOT00000021769
resolver
genesymbol
Ciapin1
resolver
uniprot_entry
CPIN1_RAT
resolver
amino_acid_sequence
MAEFGISPGQLVAVFCDKSSSEEALKKLVGRVQGLTGSEGQVFVENITQLLQSAHKESSFDVILSGIVPGSTSLHSPEALADMARILRPGGCLFLKEPVETTGVNNDKIKTASKLCSALTLSGLVEIKELQREALSPEEAQSMQEHLGYHSDSLLSVHVTGKKPNFEVGSSSQLKLLHKKSSSVKPVVDPATAKLWTLSANDMEDDSMDLIDSDELLDPEDLKKPDPASLKAPSCGEGKKRKACKNCTCGLAEELEKEQSKAQSSQPKSACGNCYLGDAFRCANCPYLGMPAFKPGEQVLLSSSNLQDA
uniprot
proteins
function
FUNCTION: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells. {ECO:0000255|HAMAP-Rule:MF_03115}.
uniprot
proteins
mass_dalton
33042
uniprot
proteins
protein_family
Anamorsin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
309
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03115}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03115}. Mitochondrion intermembrane space {ECO:0000255|HAMAP-Rule:MF_03115}.
uniprot
proteins