RABL2B
entrez
11158
canonical
uniprot
Q9UNT1
canonical
ensembl
ENSG00000079974
resolver
ensp
ENSP00000346940
resolver
ensp
ENSP00000378958
resolver
ensp
ENSP00000378960
resolver
ensp
ENSP00000378962
resolver
ensp
ENSP00000509250
resolver
ensp
ENSP00000557343
resolver
ensp
ENSP00000557344
resolver
ensp
ENSP00000557345
resolver
ensp
ENSP00000557346
resolver
ensp
ENSP00000557348
resolver
ensp
ENSP00000557349
resolver
ensp
ENSP00000557350
resolver
ensp
ENSP00000557352
resolver
ensp
ENSP00000557353
resolver
ensp
ENSP00000557354
resolver
ensp
ENSP00000557356
resolver
ensp
ENSP00000557361
resolver
ensp
ENSP00000557366
resolver
ensp
ENSP00000557367
resolver
ensp
ENSP00000557371
resolver
ensp
ENSP00000557373
resolver
ensp
ENSP00000557376
resolver
ensp
ENSP00000557377
resolver
ensp
ENSP00000557379
resolver
ensp
ENSP00000557380
resolver
ensp
ENSP00000584014
resolver
ensp
ENSP00000584015
resolver
ensp
ENSP00000584019
resolver
ensp
ENSP00000584024
resolver
ensp
ENSP00000584031
resolver
ensp
ENSP00000584035
resolver
ensp
ENSP00000584036
resolver
ensp
ENSP00000584037
resolver
ensp
ENSP00000631172
resolver
ensp
ENSP00000631174
resolver
ensp
ENSP00000631176
resolver
ensp
ENSP00000631177
resolver
ensp
ENSP00000631183
resolver
genesymbol
RABL2B
resolver
hgnc
HGNC:9800
resolver
uniprot
Q5TZT8
resolver
uniprot
Q96C33
resolver
uniprot_entry
RBL2B_HUMAN
resolver
uniprot_sec
Q5TZT8
resolver
uniprot_sec
Q96C33
resolver
amino_acid_sequence
MAEDKTKPSELDQGKYDADDNVKIICLGDSAVGKSKLMERFLMDGFQPQQLSTYALTLYKHTATVDGRTILVDFWDTAGQERFQSMHASYYHKAHACIMVFDVQRKVTYRNLSTWYTELREFRPEIPCIVVANKIDDINVTQKSFNFAKKFSLPLYFVSAADGTNVVKLFNDAIRLAVSYKQNSQDFMDEIFQELENFSLEQEEEDVPDQEQSSSIETPSEEAASPHS
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Small GTPase required for ciliation. Activated in a guanine nucleotide exchange factor (GEF)-independent manner via its intrinsic GDP for GTP nucleotide exchange ability (PubMed:28625565). Involved in ciliary assembly by binding the intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia (PubMed:28428259, PubMed:28625565). {ECO:0000269|PubMed:28428259, ECO:0000269|PubMed:28625565}.
uniprot
proteins
mass_dalton
26101
uniprot
proteins
mutagenesis
MUTAGEN 35; /note="S->N: GDP-locked form; mild defects in ciliary assembly. Loss of interaction with the intraflagellar transport (IFT) complex B via the IFT74-IFT81 heterodimer. Loss of interaction with CEP19. Loss of localization to the centrosome. Loss of localization to the base of the cilium."; /evidence="ECO:0000269|PubMed:28428259, ECO:0000269|PubMed:28625565"; MUTAGEN 73; /note="D->G: Mild defects in ciliary assembly. Loss of interaction with the intraflagellar transport (IFT) complex B via the IFT74-IFT81 heterodimer. Interacts with CEP19."; /evidence="ECO:0000269|PubMed:28428259"; MUTAGEN 80; /note="Q->L: GTP-locked form; interacts with the intraflagellar transport (IFT) complex B via the IFT74-IFT81 heterodimer. Localizes to the base of the cilium and accumulates within the cilium and at the tip in specific puncta."; /evidence="ECO:0000269|PubMed:28428259, ECO:0000269|PubMed:28625565
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10444334
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23055941
uniprot
proteins
pubmed
28428259
uniprot
proteins
pubmed
28625565
uniprot
proteins
sequence_length
228
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:28428259, ECO:0000269|PubMed:28625565}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:28428259}. Cytoplasm {ECO:0000269|PubMed:28625565}. Note=Localizes on the mother centriole. Localizes slightly apical to the subdistal appendage, but below the distal appendage. {ECO:0000269|PubMed:28625565}.
uniprot
proteins