Hgfac
entrez
54426
canonical
uniprot
Q9R098
canonical
ensembl
ENSMUSG00000029102
resolver
ensp
ENSMUSP00000030985
resolver
ensp
ENSMUSP00000315193
resolver
ensp
ENSMUSP00000315195
resolver
ensp
ENSMUSP00000348782
resolver
enst
ENSMUST00000030985
resolver
genesymbol
Hgfac
resolver
uniprot
Q545J3
resolver
uniprot
Q9JKV4
resolver
uniprot_entry
HGFA_MOUSE
resolver
uniprot_entry
Q545J3_MOUSE
resolver
uniprot_sec
Q9JKV4
resolver
amino_acid_sequence
MGRQAWISSLCPLPRPCPFLLLLLLLVVPRGAQPQAGRNHTEPPGPNVTATPVTPTIPVISGNVSTSTESAPAAETEGPQSERYPPPSSSSPPGGQVLTESGQPCRFPFRYGGRMLHSCTSEGSAYRKWCATTHNYDRDRAWGYCAEVTLPVEGPAILDPCASGPCLNGGTCSSTHDHGSYHCSCPLAFTGKDCGTEKCFDETRYEYFEVGDHWARVSEGHVEQCGCMEGQARCEDTHHTACLSSPCLNGGTCHLIVGTGTSVCTCPLGYAGRFCNIVPTEHCFLGNGTEYRGVASTAASGLSCLAWNSDLLYQELHVDSVAAAVLLGLGPHAYCRNPDKDERPWCYVVKDNALSWEYCRLTACESLARVHSQTPEILAALPESAPAVRPTCGKRHKKRTFLRPRIIGGSSSLPGSHPWLAAIYIGNSFCAGSLVHTCWVVSAAHCFANSPPRDSITVVLGQHFFNRTTDVTQTFGIEKYVPYTLYSVFNPNNHDLVLIRLKKKGERCAVRSQFVQPICLPEAGSSFPTGHKCQIAGWGHMDENVSSYSNSLLEALVPLVADHKCSSPEVYGADISPNMLCAGYFDCKSDACQGDSGGPLVCEKNGVAYLYGIISWGDGCGRLNKPGVYTRVANYVDWINDRIRPPKRPVATS
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Serine protease that hydrolyzes the inactive zymogen hepatocyte growth factor (HGFsc) to an activated disulfide-linked heterodimer, then initiating hepatocyte growth factor receptor signaling pathway. {ECO:0000269|PubMed:11032833}.
uniprot
proteins
mass_dalton
70568
uniprot
proteins
post_translational_modification
PTM: The active form of HGFAC presents in the serum is derived from the COOH-terminal region of the precursor by the cleavage of bonds between Arg-369 and Val-370 and Arg-405 and Ile-406. {ECO:0000250|UniProtKB:Q04756}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
10760594
uniprot
proteins
pubmed
11032833
uniprot
proteins
pubmed
16944957
uniprot
proteins
pubmed
17330941
uniprot
proteins
sequence_length
653
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11032833}. Note=Exists as an inactive zymogen in plasma. Exists as an active heterodimeric form in serum. {ECO:0000250|UniProtKB:Q04756}.
uniprot
proteins