Prr5l
entrez
362171
canonical
uniprot
A1L1K1
canonical
ensembl
ENSRNOG00000004666
resolver
ensp
ENSRNOP00000006291
resolver
enst
ENSRNOT00000006291
resolver
genesymbol
Prr5l
resolver
genesymbol_syn
Protor2
resolver
uniprot
F1LQP5
resolver
uniprot_entry
F1LQP5_RAT
resolver
uniprot_entry
PRR5L_RAT
resolver
amino_acid_sequence
MTRGLAPLLPIEFHKMGSFRRPRPRFMSSPLLSELPRFQAARQALQLSSNSAWNSVQTAVINVFKGGGLQSNELYALNESIRRLLKSELGSFITDYFQNQLLAKGLSFVEEKIKQCEGDNRIEVLAEVWDHFFTETLPTLQAIFYPVQGQELTIRQISLLGFRDLVLLKVKLGDLLLLSQSKLPSSVIQMLLILQSVHEPTGPSEGYLQLEELVKQVVSPFLGLSGDRSCSRPTHSLARRHSRVRPKVTVLNYASLMTTVGRPLNEMVLTPLTEQEGEAYLEKCGSVRRHTVANAHSDIQLLAMATMMHSGLGEESGSEDKHLLLPPTFPPPHRQCSSEPSILDSPDEMELEDVASGSQEDSELNCASLS
uniprot
proteins
function
FUNCTION: Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton. Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration. Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF and GM-CSF, in response to stress. Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress. {ECO:0000250|UniProtKB:Q6MZQ0}.
uniprot
proteins
mass_dalton
41162
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Ubiquitination by RFFL promotes proteasomal degradation of PRR5L thereby modifying the substrate-specific activity of the mTORC2 complex. Ubiquitination by RFFL is stimulated by LPA/lysophosphatidic acid (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
PROTOR family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
370
uniprot
proteins