Psat1
entrez
107272
canonical
uniprot
Q99K85
canonical
ensembl
ENSMUSG00000024640
resolver
ensp
ENSMUSP00000025542
resolver
ensp
ENSMUSP00000125340
resolver
enst
ENSMUST00000025542
resolver
enst
ENSMUST00000162053
resolver
genesymbol
Psat1
resolver
genesymbol_syn
Psa
resolver
genesymbol_syn
Psat
resolver
uniprot
F7CC79
resolver
uniprot
Q3U6K9
resolver
uniprot
Q543K5
resolver
uniprot_entry
F7CC79_MOUSE
resolver
uniprot_entry
Q3U6K9_MOUSE
resolver
uniprot_entry
Q543K5_MOUSE
resolver
uniprot_entry
SERC_MOUSE
resolver
amino_acid_sequence
MEATKQVVNFGPGPAKLPHSVLLEIQKQLLDYRGLGISVLEMSHRSSDFAKIIGNTENLVRELLAVPNNYKVIFVQGGGSGQFSAVPLNLIGLKAGRSADYVVTGAWSAKAAEEAKKFGTVNIVHPKLGSYTKIPDPSTWNLNPDASYVYFCANETVHGVEFDFVPDVKGAVLVCDMSSNFLSRPVDVSKFGVIFAGAQKNVGSAGVTVVIVRDDLLGFSLRECPSVLDYKVQAGNNSLYNTPPCFSIYVMGMVLEWIKNNGGAAAMEKLSSIKSQMIYEIIDNSQGFYVCPVERQNRSRMNIPFRIGNAKGDEALEKRFLDKAVELNMISLKGHRSVGGIRASLYNAVTTEDVEKLAAFMKNFLEMHQL
uniprot
proteins
ec_number
2.6.1.52
uniprot
proteins
function
FUNCTION: Involved in L-serine biosynthesis via the phosphorylated pathway, a three-step pathway converting the glycolytic intermediate 3-phospho-D-glycerate into L-serine. Catalyzes the second step, that is the pyridoxal 5'-phosphate-dependent transamination of 3-phosphohydroxypyruvate and L-glutamate to O-phosphoserine (OPS) and alpha-ketoglutarate. Acts as an inhibitor of ferroptosis in response to interferon-gamma (IFNG) by promoting GPX4 stability: following phosphorylation by CAMK2A, PSAT1 interacts with GPX4 and provides 2-oxoglutarate to EGLN3, leading to GPX4 hydroxylation and stability. {ECO:0000250|UniProtKB:Q9Y617}.
uniprot
proteins
mass_dalton
40473
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3. {ECO:0000250|UniProtKB:Q9Y617}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-337 by CAMK2A in response to interferon-gamma (IFNG), promoting interaction with GPX4 and GPX4 hydroxylation by EGLN3. {ECO:0000250|UniProtKB:Q9Y617}.
uniprot
proteins
protein_family
Class-V pyridoxal-phosphate-dependent aminotransferase family
uniprot
proteins
protein_family
SerC subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
370
uniprot
proteins