Cenpx
entrez
20892
canonical
uniprot
Q8C4X1
canonical
ensembl
ENSMUSG00000025144
resolver
ensp
ENSMUSP00000026137
resolver
ensp
ENSMUSP00000050335
resolver
ensp
ENSMUSP00000101760
resolver
ensp
ENSMUSP00000167469
resolver
ensp
ENSMUSP00000167471
resolver
ensp
ENSMUSP00000167472
resolver
ensp
ENSMUSP00000167483
resolver
ensp
ENSMUSP00000341175
resolver
ensp
ENSMUSP00000365228
resolver
enst
ENSMUST00000106154
resolver
genesymbol
Cenpx
resolver
genesymbol_syn
Faap10
resolver
genesymbol_syn
Mhf2
resolver
genesymbol_syn
Stra13
resolver
uniprot
A2AC07
resolver
uniprot
A2AC08
resolver
uniprot
O08693
resolver
uniprot
O08694
resolver
uniprot
O08695
resolver
uniprot
Q8BPD7
resolver
uniprot_entry
A2AC07_MOUSE
resolver
uniprot_entry
CENPX_MOUSE
resolver
uniprot_sec
A2AC08
resolver
uniprot_sec
O08693
resolver
uniprot_sec
O08694
resolver
uniprot_sec
O08695
resolver
uniprot_sec
Q8BPD7
resolver
amino_acid_sequence
MEGNSGFRKELVSRLLHLHFRDCKTKVSGDALQLMAEFLRIFVLEAAVRGVWQAQAEDLDVVEVDQLEKVLPQLLLDF
uniprot
proteins
function
FUNCTION: DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks. In complex with CENPS, CENPT and CENPW (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure. DNA-binding function is fulfilled in the presence of CENPS, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own. {ECO:0000250|UniProtKB:A8MT69}.
uniprot
proteins
mass_dalton
8926
uniprot
proteins
protein_family
CENP-X/MHF2 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
8839844
uniprot
proteins
sequence_length
78
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:A8MT69}. Chromosome, centromere {ECO:0000250|UniProtKB:A8MT69}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:A8MT69}. Note=Assembly of CENPS and CENPX and its partner subunits CENPT and CENPW at centromeres occurs through a dynamic exchange mechanism. Although exchange is continuous in the cell cycle, de novo assembly starts principally during mid-late S phase and is complete by G2. CENPX being less stably bound at the kinetochore than CENPS. {ECO:0000250|UniProtKB:A8MT69}.
uniprot
proteins