Tecr
entrez
106529
canonical
uniprot
Q9CY27
canonical
ensembl
ENSMUSG00000031708
resolver
ensp
ENSMUSP00000019382
resolver
ensp
ENSMUSP00000131389
resolver
enst
ENSMUST00000019382
resolver
enst
ENSMUST00000165740
resolver
genesymbol
Tecr
resolver
genesymbol_syn
Gpsn2
resolver
uniprot
G3UWE1
resolver
uniprot_entry
G3UWE1_MOUSE
resolver
uniprot_entry
TECR_MOUSE
resolver
amino_acid_sequence
MKHYEVEIRDAKTREKLCFLDKVEPQATISEIKTLFTKTHPQWYPARQSLRLDPKGKSLKDEDVLQKLPVGTTATLYFRDLGAQISWVTVFLTEYAGPLFIYLLFYFRVPFIYGRKYDFTSSRHTVVHLACMCHSFHYIKRLLETLFVHRFSHGTMPLRNIFKNCTYYWGFAAWMAYYINHPLYTPPTYGVQQVKLALAVFVICQLGNFSIHMALRDLRPAGSKTRKIPYPTKNPFTWLFLLVSCPNYTYEVGSWIGFAILTQCVPVALFSLVGFTQMTIWAKGKHRSYLKEFRDYPPLRMPIIPFLL
uniprot
proteins
ec_number
1.3.1.93
uniprot
proteins
function
FUNCTION: Involved in both the production of very long-chain fatty acids for sphingolipid synthesis and the degradation of the sphingosine moiety in sphingolipids through the sphingosine 1-phosphate metabolic pathway (By similarity). Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle (By similarity). This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle (By similarity). This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation (By similarity). Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators (By similarity). Catalyzes the saturation step of the sphingosine 1-phosphate metabolic pathway, the conversion of trans-2-hexadecenoyl-CoA to palmitoyl-CoA (By similarity). {ECO:0000250|UniProtKB:Q9NZ01}.
uniprot
proteins
mass_dalton
36090
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000250|UniProtKB:Q9NZ01}.; PATHWAY: Lipid metabolism; sphingolipid metabolism. {ECO:0000250|UniProtKB:Q9NZ01}.
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:Q64232}.
uniprot
proteins
protein_family
Steroid 5-alpha reductase family
uniprot
proteins
pubmed
12482854
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17208939
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
308
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9NZ01}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 87..106; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NZ01"; TRANSMEM 125..147; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NZ01"; TRANSMEM 159..180; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NZ01"; TRANSMEM 190..216; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NZ01"; TRANSMEM 246..262; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NZ01"; TRANSMEM 265..292; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NZ01
uniprot
proteins