TRAF3IP2
entrez
10758
canonical
uniprot
O43734
canonical
ensembl
ENSG00000056972
resolver
ensp
ENSP00000345984
resolver
ensp
ENSP00000352889
resolver
ensp
ENSP00000357724
resolver
ensp
ENSP00000357750
resolver
genesymbol
TRAF3IP2
resolver
genesymbol_syn
C6orf2
resolver
genesymbol_syn
C6orf4
resolver
genesymbol_syn
C6orf5
resolver
genesymbol_syn
C6orf6
resolver
hgnc
HGNC:1343
resolver
uniprot
B2RAY9
resolver
uniprot
E1P555
resolver
uniprot
Q5R3A3
resolver
uniprot
Q7Z6Q1
resolver
uniprot
Q7Z6Q2
resolver
uniprot
Q7Z6Q3
resolver
uniprot
Q9H5W2
resolver
uniprot
Q9H6Y3
resolver
uniprot
Q9NS14
resolver
uniprot
Q9UG72
resolver
uniprot_entry
CIKS_HUMAN
resolver
uniprot_sec
B2RAY9
resolver
uniprot_sec
E1P555
resolver
uniprot_sec
Q5R3A3
resolver
uniprot_sec
Q7Z6Q1
resolver
uniprot_sec
Q7Z6Q2
resolver
uniprot_sec
Q7Z6Q3
resolver
uniprot_sec
Q9H5W2
resolver
uniprot_sec
Q9H6Y3
resolver
uniprot_sec
Q9NS14
resolver
uniprot_sec
Q9UG72
resolver
amino_acid_sequence
MPPQLQETRMNRSIPVEVDESEPYPSQLLKPIPEYSPEEESEPPAPNIRNMAPNSLSAPTMLHNSSGDFSQAHSTLKLANHQRPVSRQVTCLRTQVLEDSEDSFCRRHPGLGKAFPSGCSAVSEPASESVVGALPAEHQFSFMEKRNQWLVSQLSAASPDTGHDSDKSDQSLPNASADSLGGSQEMVQRPQPHRNRAGLDLPTIDTGYDSQPQDVLGIRQLERPLPLTSVCYPQDLPRPLRSREFPQFEPQRYPACAQMLPPNLSPHAPWNYHYHCPGSPDHQVPYGHDYPRAAYQQVIQPALPGQPLPGASVRGLHPVQKVILNYPSPWDHEERPAQRDCSFPGLPRHQDQPHHQPPNRAGAPGESLECPAELRPQVPQPPSPAAVPRPPSNPPARGTLKTSNLPEELRKVFITYSMDTAMEVVKFVNFLLVNGFQTAIDIFEDRIRGIDIIKWMERYLRDKTVMIIVAISPKYKQDVEGAESQLDEDEHGLHTKYIHRMMQIEFIKQGSMNFRFIPVLFPNAKKEHVPTWLQNTHVYSWPKNKKNILLRLLREEEYVAPPRGPLPTLQVVPL
uniprot
proteins
disease_involvement
DISEASE: Psoriasis 13 (PSORS13) [MIM:614070]: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. {ECO:0000269|PubMed:20953186, ECO:0000269|PubMed:20953188}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; DISEASE: Candidiasis, familial, 8 (CANDF8) [MIM:615527]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. {ECO:0000269|PubMed:24120361}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling (PubMed:19825828). Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein (PubMed:19825828). Essential adapter molecule in IL17A-mediated signaling (PubMed:19825828, PubMed:24120361). Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways (PubMed:19825828). {ECO:0000269|PubMed:19825828, ECO:0000269|PubMed:24120361, ECO:0000269|PubMed:33723527}.
uniprot
proteins
mass_dalton
64666
uniprot
proteins
mutagenesis
MUTAGEN 303; /note="L->G: Loss of E3 ubiquitin ligase activity."; /evidence="ECO:0000269|PubMed:19825828"; MUTAGEN 318; /note="P->G: Decreases E3 ubiquitin ligase activity."; /evidence="ECO:0000269|PubMed:19825828"; MUTAGEN 319; /note="V->R: Loss of E3 ubiquitin ligase activity."; /evidence="ECO:0000269|PubMed:19825828"; MUTAGEN 324; /note="L->R: Decreases E3 ubiquitin ligase activity."; /evidence="ECO:0000269|PubMed:19825828
uniprot
proteins
pubmed
10903453
uniprot
proteins
pubmed
10962024
uniprot
proteins
pubmed
10962033
uniprot
proteins
pubmed
12459498
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19825828
uniprot
proteins
pubmed
20953186
uniprot
proteins
pubmed
20953188
uniprot
proteins
pubmed
24120361
uniprot
proteins
pubmed
33723527
uniprot
proteins
sequence_length
574
uniprot
proteins