HNRNPF
entrez
3185
canonical
uniprot
P52597
canonical
ensembl
ENSG00000169813
resolver
ensp
ENSP00000338477
resolver
ensp
ENSP00000348345
resolver
ensp
ENSP00000349573
resolver
ensp
ENSP00000400433
resolver
ensp
ENSP00000438061
resolver
ensp
ENSP00000507787
resolver
ensp
ENSP00000524229
resolver
ensp
ENSP00000524230
resolver
ensp
ENSP00000524231
resolver
ensp
ENSP00000524232
resolver
ensp
ENSP00000524233
resolver
ensp
ENSP00000524234
resolver
ensp
ENSP00000524235
resolver
ensp
ENSP00000524236
resolver
ensp
ENSP00000524237
resolver
ensp
ENSP00000524238
resolver
ensp
ENSP00000524239
resolver
ensp
ENSP00000524240
resolver
ensp
ENSP00000524241
resolver
ensp
ENSP00000524242
resolver
ensp
ENSP00000524243
resolver
ensp
ENSP00000524244
resolver
ensp
ENSP00000524245
resolver
ensp
ENSP00000524246
resolver
ensp
ENSP00000524247
resolver
ensp
ENSP00000524248
resolver
ensp
ENSP00000524249
resolver
ensp
ENSP00000524250
resolver
ensp
ENSP00000524251
resolver
ensp
ENSP00000524252
resolver
ensp
ENSP00000524253
resolver
ensp
ENSP00000524254
resolver
ensp
ENSP00000524255
resolver
ensp
ENSP00000524256
resolver
ensp
ENSP00000593181
resolver
ensp
ENSP00000593182
resolver
ensp
ENSP00000593183
resolver
ensp
ENSP00000593184
resolver
ensp
ENSP00000593185
resolver
ensp
ENSP00000593186
resolver
ensp
ENSP00000593187
resolver
ensp
ENSP00000593188
resolver
ensp
ENSP00000593189
resolver
ensp
ENSP00000593190
resolver
ensp
ENSP00000593191
resolver
ensp
ENSP00000593192
resolver
ensp
ENSP00000593193
resolver
ensp
ENSP00000593194
resolver
ensp
ENSP00000593195
resolver
ensp
ENSP00000593196
resolver
ensp
ENSP00000593197
resolver
ensp
ENSP00000593198
resolver
ensp
ENSP00000593199
resolver
ensp
ENSP00000593200
resolver
ensp
ENSP00000593201
resolver
ensp
ENSP00000593202
resolver
ensp
ENSP00000629002
resolver
ensp
ENSP00000629003
resolver
ensp
ENSP00000629004
resolver
ensp
ENSP00000629005
resolver
ensp
ENSP00000629006
resolver
ensp
ENSP00000629007
resolver
ensp
ENSP00000629008
resolver
ensp
ENSP00000629009
resolver
ensp
ENSP00000629010
resolver
ensp
ENSP00000629011
resolver
ensp
ENSP00000629012
resolver
ensp
ENSP00000629013
resolver
enst
ENST00000337970
resolver
enst
ENST00000356053
resolver
enst
ENST00000357065
resolver
enst
ENST00000443950
resolver
enst
ENST00000544000
resolver
enst
ENST00000682386
resolver
enst
ENST00000854170
resolver
enst
ENST00000854171
resolver
enst
ENST00000854172
resolver
enst
ENST00000854173
resolver
enst
ENST00000854174
resolver
enst
ENST00000854175
resolver
enst
ENST00000854176
resolver
enst
ENST00000854177
resolver
enst
ENST00000854178
resolver
enst
ENST00000854179
resolver
enst
ENST00000854180
resolver
enst
ENST00000854181
resolver
enst
ENST00000854182
resolver
enst
ENST00000854183
resolver
enst
ENST00000854184
resolver
enst
ENST00000854185
resolver
enst
ENST00000854186
resolver
enst
ENST00000854187
resolver
enst
ENST00000854188
resolver
enst
ENST00000854189
resolver
enst
ENST00000854190
resolver
enst
ENST00000854191
resolver
enst
ENST00000854192
resolver
enst
ENST00000854193
resolver
enst
ENST00000854194
resolver
enst
ENST00000854195
resolver
enst
ENST00000854196
resolver
enst
ENST00000854197
resolver
enst
ENST00000923122
resolver
enst
ENST00000923123
resolver
enst
ENST00000923124
resolver
enst
ENST00000923125
resolver
enst
ENST00000923126
resolver
enst
ENST00000923127
resolver
enst
ENST00000923128
resolver
enst
ENST00000923129
resolver
enst
ENST00000923130
resolver
enst
ENST00000923131
resolver
enst
ENST00000923132
resolver
enst
ENST00000923133
resolver
enst
ENST00000923134
resolver
enst
ENST00000923135
resolver
enst
ENST00000923136
resolver
enst
ENST00000923137
resolver
enst
ENST00000923138
resolver
enst
ENST00000923139
resolver
enst
ENST00000923140
resolver
enst
ENST00000923141
resolver
enst
ENST00000923142
resolver
enst
ENST00000923143
resolver
enst
ENST00000958943
resolver
enst
ENST00000958944
resolver
enst
ENST00000958945
resolver
enst
ENST00000958946
resolver
enst
ENST00000958947
resolver
enst
ENST00000958948
resolver
enst
ENST00000958949
resolver
enst
ENST00000958950
resolver
enst
ENST00000958951
resolver
enst
ENST00000958952
resolver
enst
ENST00000958953
resolver
enst
ENST00000958954
resolver
genesymbol
HNRNPF
resolver
genesymbol_syn
HNRPF
resolver
hgnc
HGNC:5039
resolver
uniprot
B3KM84
resolver
uniprot
Q5T0N2
resolver
uniprot
Q96AU2
resolver
uniprot_entry
HNRPF_HUMAN
resolver
uniprot_sec
B3KM84
resolver
uniprot_sec
Q5T0N2
resolver
uniprot_sec
Q96AU2
resolver
amino_acid_sequence
MMLGPEGGEGFVVKLRGLPWSCSVEDVQNFLSDCTIHDGAAGVHFIYTREGRQSGEAFVELGSEDDVKMALKKDRESMGHRYIEVFKSHRTEMDWVLKHSGPNSADSANDGFVRLRGLPFGCTKEEIVQFFSGLEIVPNGITLPVDPEGKITGEAFVQFASQELAEKALGKHKERIGHRYIEVFKSSQEEVRSYSDPPLKFMSVQRPGPYDRPGTARRYIGIVKQAGLERMRPGAYSTGYGGYEEYSGLSDGYGFTTDLFGRDLSYCLSGMYDHRYGDSEFTVQSTTGHCVHMRGLPYKATENDIYNFFSPLNPVRVHIEIGPDGRVTGEADVEFATHEEAVAAMSKDRANMQHRYIELFLNSTTGASNGAYSSQVMQGMGVSAAQATYSGLESQSVSGCYGAGYSGQNSMGGYD
uniprot
proteins
function
FUNCTION: Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Plays a role in the regulation of alternative splicing events. Binds G-rich sequences in pre-mRNAs and keeps target RNA in an unfolded state. {ECO:0000269|PubMed:20526337}.
uniprot
proteins
mass_dalton
45672
uniprot
proteins
mutagenesis
MUTAGEN 20; /note="W->A: Loss of RNA-binding."; /evidence="ECO:0000269|PubMed:20526337"; MUTAGEN 84; /note="E->A: Loss of RNA-binding."; /evidence="ECO:0000269|PubMed:20526337"; MUTAGEN 116; /note="R->A: Decreases affinity for RNA oligonucleotide 100-fold."; /evidence="ECO:0000269|PubMed:20526337"; MUTAGEN 120; /note="F->A: Little disruption of binding RNA. Decreases affinity for RNA oligonucleotide 100-fold. Abrogates RNA-binding; when associated with A-180."; /evidence="ECO:0000269|PubMed:16885237, ECO:0000269|PubMed:20526337"; MUTAGEN 150; /note="K->A: No effect on affinity for RNA oligonucleotide."; /evidence="ECO:0000269|PubMed:20526337"; MUTAGEN 156; /note="F->A: Drastically effects folding of RRM2."; /evidence="ECO:0000269|PubMed:16885237"; MUTAGEN 173; /note="K->A: Minimal effect on affinity for RNA oligonucleotide."; /evidence="ECO:0000269|PubMed:20526337"; MUTAGEN 178; /note="H->A: Little disruption of binding RNA."; /evidence="ECO:0000269|PubMed:16885237"; MUTAGEN 179; /note="R->A: Decreases affinity for RNA oligonucleotide 100-fold."; /evidence="ECO:0000269|PubMed:20526337"; MUTAGEN 180; /note="Y->A: Decreases affinity for RNA oligonucleotide 10-fold. Abrogates RNA-binding; when associated with A-120."; /evidence="ECO:0000269|PubMed:16885237, ECO:0000269|PubMed:20526337"; MUTAGEN 182; /note="E->A: Decreases affinity for RNA oligonucleotide 100-fold."; /evidence="ECO:0000269|PubMed:20526337"; MUTAGEN 184; /note="F->A: Minimal effect on affinity for RNA oligonucleotide."; /evidence="ECO:0000269|PubMed:20526337
uniprot
proteins
post_translational_modification
PTM: Sumoylated. {ECO:0000269|PubMed:15161980}.
uniprot
proteins
pubmed
11054566
uniprot
proteins
pubmed
11991638
uniprot
proteins
pubmed
1351868
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15161980
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16885237
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
17932509
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20526337
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
7499401
uniprot
proteins
pubmed
7512260
uniprot
proteins
sequence_length
415
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm.
uniprot
proteins