Fshr
entrez
14309
canonical
uniprot
P35378
canonical
ensembl
ENSMUSG00000032937
resolver
ensp
ENSMUSP00000040477
resolver
enst
ENSMUST00000035701
resolver
genesymbol
Fshr
resolver
genesymbol_syn
FSHR
resolver
uniprot
B2RQM3
resolver
uniprot
Q9D4C2
resolver
uniprot
Q9QWV8
resolver
uniprot_entry
B2RQM3_MOUSE
resolver
uniprot_entry
FSHR_MOUSE
resolver
uniprot_sec
Q9D4C2
resolver
uniprot_sec
Q9QWV8
resolver
amino_acid_sequence
MALLLVSLLAFLGSGSGCHHWLCHCSNRVFLCQDSKVTEIPPDLPRNAIELRFVLTKLRVIPKGSFSGFGDLEKIEISQNDVLEVIEADVFSNLPNLHEIRIEKANNLLYINPEAFQNLPSLRYLLISNTGIKHLPAFHKIQSLQKVLLDIQDNINIHIIARNSFMGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPDDVFQGASGPVVLDISRTKVYSLPNHGLENLKKLRARSTYRLKKLPSLDKFVMLIEASLTYPSHCCAFANWRRQTSELHPICNKSISRQDIDDMTQPGDQRVSLVDDEPSYGKGSDMLYSEFDYDLCNEFVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNTTVLVVLTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLAAITLERWHTITHAMQLECKVQLCHAASIMVLGWAFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMALLVLNALAFVVICGCYTHIYLTVRNPNIVSSSRDTKIAKRMATLIFTDFLCMAPILFFAISASLKVPLITVSKAKILLVLFYPINSCANPFLYAIFTKNFRRDFFVLMSKFGCYEVQAQIYKTETSSITHNFHSRKNPCSSAPRVTNSYVLVPLNHSVQN
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Mediates FSH signaling through cAMP/protein kinase A (PKA) and phosphatidylinositol-3 kinase (PI3K)/protein kinase B (AKT) pathways to regulate ovarian follicular development and steroidogenesis (By similarity). Has diverse extragonadal functions: signals via a GNAI2-coupled FSHR on osteoclasts and their precursors, resulting in activation of MEK/ERK, NF-kappa-B, and AKT pathways and thus increases osteoclastogenesis and bone resorption (PubMed:16630814). Also regulates glucose-stimulated insulin secretion in pancreatic beta-cells in a bell curve manner, with moderate FSH levels promoting insulin secretion via Galphas/cAMP/PKA pathways while high FSH levels inhibit this effect through Galphai coupling (PubMed:37914684). In adipose tissue, inhibits thermogenesis by suppressing UCP1 expression and promotes lipogenesis via CREB/PPARgamma pathways (PubMed:28538730). Also affects hepatic cholesterol metabolism by increasing serum total and low-density-lipoprotein cholesterol (LDL-C) by inhibiting the expression of LDL receptor (LDLR)(PubMed:37914684). {ECO:0000250|UniProtKB:P23945, ECO:0000269|PubMed:16630814, ECO:0000269|PubMed:28538730, ECO:0000269|PubMed:37914684}.
uniprot
proteins
mass_dalton
77769
uniprot
proteins
post_translational_modification
PTM: N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone. {ECO:0000250|UniProtKB:P20395}.; PTM: Sulfated. {ECO:0000250|UniProtKB:P23945}.
uniprot
proteins
protein_family
FSH/LSH/TSH subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10330114
uniprot
proteins
pubmed
1459341
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16630814
uniprot
proteins
pubmed
28538730
uniprot
proteins
pubmed
37914684
uniprot
proteins
sequence_length
692
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P23945}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23945}.
uniprot
proteins
transmembrane_region
TRANSMEM 366..386; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 398..420; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 443..464; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 485..507; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 528..549; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 573..596; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 608..629; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins