KLHL10
entrez
317719
canonical
uniprot
Q6JEL2
canonical
ensembl
ENSG00000161594
resolver
ensp
ENSP00000293303
resolver
ensp
ENSP00000529893
resolver
ensp
ENSP00000583086
resolver
ensp
ENSP00000629931
resolver
enst
ENST00000293303
resolver
enst
ENST00000859834
resolver
enst
ENST00000913027
resolver
enst
ENST00000959872
resolver
genesymbol
KLHL10
resolver
hgnc
HGNC:18829
resolver
uniprot
A0A140VJM8
resolver
uniprot
B4DX37
resolver
uniprot
Q6NW28
resolver
uniprot
Q96MC0
resolver
uniprot_entry
A0A140VJM8_HUMAN
resolver
uniprot_entry
B4DX37_HUMAN
resolver
uniprot_entry
KLH10_HUMAN
resolver
uniprot_sec
Q6NW28
resolver
uniprot_sec
Q96MC0
resolver
amino_acid_sequence
MEMESAAASTRFHQPHMERKMSAMACEIFNELRLEGKLCDVVIKVNGFEFSAHKNILCSCSSYFRALFTSGWNNTEKKVYNIPGISPDMMKLIIEYAYTRTVPITPDNVEKLLAAADQFNIMGIVRGCCEFLKSELCLDNCIGICKFTDYYYCPELRQKAYMFILHNFEEMVKVSAEFLELSVTELKDIIEKDELNVKQEDAVFEAILKWISHDPQNRKQHISILLPKVRLALMHAEYFMNNVKMNDYVKDSEECKPVIINALKAMYDLNMNGPSNSDFTNPLTRPRLPYAILFAIGGWSGGSPTNAIEAYDARADRWVNVTCEEESPRAYHGAAYLKGYVYIIGGFDSVDYFNSVKRFDPVKKTWHQVAPMHSRRCYVSVTVLGNFIYAMGGFDGYVRLNTAERYEPETNQWTLIAPMHEQRSDASATTLYGKVYICGGFNGNECLFTAEVYNTESNQWTVIAPMRSRRSGIGVIAYGEHVYAVGGFDGANRLRSAEAYSPVANTWRTIPTMFNPRSNFGIEVVDDLLFVVGGFNGFTTTFNVECYDEKTDEWYDAHDMSIYRSALSCCVVPGLANVEEYAARRDNFPGLALRDEVKYSASTSTLPV
uniprot
proteins
disease_involvement
DISEASE: Spermatogenic failure 11 (SPGF11) [MIM:615081]: An infertility disorder caused by spermatogenesis defects. It results in decreased sperm motility, concentration, and multiple sperm structural defects. Oligozoospermia is usually observed in SPGF11 patients. In addition to oligozoospermia, teratozoospermia and moderate asthenozoospermia is observed in some cases. {ECO:0000269|PubMed:17047026}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: May be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.
uniprot
proteins
mass_dalton
68942
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15136734
uniprot
proteins
pubmed
17047026
uniprot
proteins
sequence_length
608
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins