Hao1
entrez
311446
canonical
uniprot
B0BNF9
canonical
ensembl
ENSRNOG00000004601
resolver
ensp
ENSRNOP00000006330
resolver
enst
ENSRNOT00000006330
resolver
genesymbol
Hao1
resolver
uniprot_entry
HAOX1_RAT
resolver
amino_acid_sequence
MLPRLVCISDYEQHARTVLQKSVYDYYKSGANDQETLADNIRAFSRWKLYPRMLRNVADIDLSTSVLGQRVSMPICVGATAMQCMAHVDGELATVRACQTMGTGMMLSSWATSSIEEVAEAGPEALRWMQLYIYKDREVSSQLVKRAEQMGYKAIFVTVDTPYLGNRFDDVRNRFKLPPQLRMKNFETNDLAFSPKGNFGDNSGLAEYVAQAIDPSLSWDDIKWLRRLTSLPIVVKGILRGDDAQEAVKHGVDGILVSNHGARQLDGVPATIDALPEIVEAVEGKVEVFLDGGVRKGTDVLKALALGARAVFVGRPIIWGLAFQGEKGVQDVLEILKEEFRLAMALSGCQNVKVIDKTLVRKNPLAVSKI
uniprot
proteins
ec_number
1.1.3.15
uniprot
proteins
ec_number
1.2.3.5
uniprot
proteins
function
FUNCTION: Broad substrate specificity (S)-2-hydroxy-acid oxidase that preferentially oxidizes glycolate. The glyoxylate produced by the oxidation of glycolate can then be utilized by alanine-glyoxylate aminotransferase for the peroxisomal synthesis of glycine; this pathway appears to be an important step for the detoxification of glyoxylate which, if allowed to accumulate, may be metabolized to oxalate with formation of kidney stones. Can also catalyze the oxidation of glyoxylate, and long chain hydroxyacids such as 2-hydroxyhexadecanoate and 2-hydroxyoctanoate. Active in vitro with the artificial electron acceptor 2,6-dichlorophenolindophenol (DCIP), but O2 is believed to be the physiological electron acceptor, leading to the production of H2O2. {ECO:0000250|UniProtKB:Q9UJM8}.
uniprot
proteins
mass_dalton
40968
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid biosynthesis; glycine biosynthesis. {ECO:0000250|UniProtKB:Q9UJM8}.
uniprot
proteins
protein_family
FMN-dependent alpha-hydroxy acid dehydrogenase family
uniprot
proteins
pubmed
10777549
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16396499
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
370
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome matrix {ECO:0000305|PubMed:10777549}.
uniprot
proteins