Tmem68
entrez
72098
canonical
uniprot
Q9D850
canonical
ensembl
ENSMUSG00000028232
resolver
ensp
ENSMUSP00000029891
resolver
genesymbol
Tmem68
resolver
uniprot
Q3UGT4
resolver
uniprot
Q8BTV3
resolver
uniprot_entry
DIESL_MOUSE
resolver
uniprot_sec
Q3UGT4
resolver
uniprot_sec
Q8BTV3
resolver
activity_regulation
ACTIVITY REGULATION: Acyltransferase activity is specifically inhibited by TMX1 at the endoplasmic reticulum, restricting accumulation of triacylglycerol. {ECO:0000250|UniProtKB:Q96MH6}.
uniprot
proteins
amino_acid_sequence
MIDNNQTCAAGQDSVPYVTCMIYVLEEWLGVEQLEDYLNFANHLLWVFTPLILLILPYFTIFLLYLTIIFLHIYKRKNVLKEAYSHNLWDGARKTVATLWDGHAAVWHGYEVHGMEKIPEGAALIIFYHGAIPIDFYYFMAKIFIQKGRTCRVVADHFVFKIPGFSLLLDVFCALHGPREKCVEILRSGHLLAISPGGVREALLSDETYNIIWGNRKGFAQVAIDAKVPIIPMFTQNIREGFRSLGGTRLFKWLYEKFRYPFAPMYGGFPVKLRTFLGDPIPYDPKVTAEELAEKTKNAVQALIDKHQRIPGNIRSALLDRFHKEQKAH
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
ec_number
2.3.1.20
uniprot
proteins
ec_number
2.3.1.22
uniprot
proteins
function
FUNCTION: Catalytic subunit of the alternative triglyceride biosynthesis pathway, which mediates formation of triacylglycerol from diacylglycerol and membrane phospholipids (By similarity). Synthesizes triacylglycerol at the expense of membrane phospholipids, such as phosphatidylcholine (PC) and its ether-linked form (ePC), thereby altering the composition of membranes (By similarity). The alternative triglyceride biosynthesis pathway is probably required to provide the energy required for rapid growth when fuel sources are limiting (PubMed:37648867). It maintains mitochondrial function during periods of extracellular lipid starvation (PubMed:37648867). Can also use acyl-CoA as donor: acts as a acyl-CoA:monoacylglycerol acyltransferase (MGAT), but also shows acyl-CoA:diacylglycerol acyltransferase (DGAT) activity (PubMed:36768334). {ECO:0000250|UniProtKB:Q96MH6, ECO:0000269|PubMed:36768334, ECO:0000269|PubMed:37648867}.
uniprot
proteins
mass_dalton
37810
uniprot
proteins
protein_family
Diacylglycerol acyltransferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
28472192
uniprot
proteins
pubmed
36768334
uniprot
proteins
pubmed
37648867
uniprot
proteins
sequence_length
329
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:28472192, ECO:0000269|PubMed:36768334}; Multi-pass membrane protein {ECO:0000305|PubMed:28472192}.
uniprot
proteins
transmembrane_region
TRANSMEM 51..71; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 121..141; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins