Crbn
entrez
297498
canonical
uniprot
Q56AP7
canonical
ensembl
ENSRNOG00000006534
resolver
ensembl
ENSRNOG00055019476
resolver
ensembl
ENSRNOG00060013806
resolver
ensembl
ENSRNOG00065012073
resolver
ensp
ENSRNOP00000008873
resolver
ensp
ENSRNOP00055026960
resolver
ensp
ENSRNOP00060018738
resolver
ensp
ENSRNOP00065015060
resolver
enst
ENSRNOT00000008873
resolver
enst
ENSRNOT00055033248
resolver
enst
ENSRNOT00060023584
resolver
enst
ENSRNOT00065019629
resolver
genesymbol
Crbn
resolver
uniprot
A1L110
resolver
uniprot
Q499S7
resolver
uniprot_entry
CRBN_RAT
resolver
uniprot_sec
A1L110
resolver
uniprot_sec
Q499S7
resolver
amino_acid_sequence
MAGEGDHQDAAHNMGNHLPLLPADSEDEDDEIEMEVEDQDSKEARKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPEVMMILIPGQTLPLQLSHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQEFGIEVVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPISWEDQYSCKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKEDSLPANPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKASNLNLIGRPSTVHSWFPGYAWTIAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPETEDEISPDKVILCL
uniprot
proteins
function
FUNCTION: Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2, ILF2, GLUL, IKZF1 and CSNK1A1 (By similarity). Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8 (By similarity). Maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons (By similarity). Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1 (By similarity). May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism (By similarity). Plays a negative role in TLR4 signaling by interacting with TRAF6 and ECSIT, leading to inhibition of ECSIT ubiquitination, an important step of the signaling (By similarity). {ECO:0000250|UniProtKB:Q8C7D2, ECO:0000250|UniProtKB:Q96SW2}.
uniprot
proteins
mass_dalton
50877
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q96SW2}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, ubiquitination is mediated by its own DCX protein ligase complex. {ECO:0000250|UniProtKB:Q96SW2}.
uniprot
proteins
protein_family
CRBN family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16045448
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
445
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16045448}. Nucleus {ECO:0000250|UniProtKB:Q96SW2}. Membrane {ECO:0000269|PubMed:16045448}; Peripheral membrane protein {ECO:0000269|PubMed:16045448}.
uniprot
proteins