HIP1
entrez
3092
canonical
uniprot
O00291
canonical
ensembl
ENSG00000127946
resolver
ensp
ENSP00000336747
resolver
ensp
ENSP00000410300
resolver
ensp
ENSP00000484528
resolver
genesymbol
HIP1
resolver
hgnc
HGNC:4913
resolver
uniprot
B4DK46
resolver
uniprot
B4E3I7
resolver
uniprot
E7ES17
resolver
uniprot
O00328
resolver
uniprot
Q2TB58
resolver
uniprot
Q8TDL4
resolver
uniprot
V5LU97
resolver
uniprot_entry
B4DK46_HUMAN
resolver
uniprot_entry
HIP1_HUMAN
resolver
uniprot_sec
B4E3I7
resolver
uniprot_sec
E7ES17
resolver
uniprot_sec
O00328
resolver
uniprot_sec
Q2TB58
resolver
uniprot_sec
Q8TDL4
resolver
uniprot_sec
V5LU97
resolver
amino_acid_sequence
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQTVSINKAINTQEVAVKEKHARTCILGTHHEKGAQTFWSVVNRLPLSSNAVLCWKFCHVFHKLLRDGHPNVLKDSLRYRNELSDMSRMWGHLSEGYGQLCSIYLKLLRTKMEYHTKNPRFPGNLQMSDRQLDEAGESDVNNFFQLTVEMFDYLECELNLFQTVFNSLDMSRSVSVTAAGQCRLAPLIQVILDCSHLYDYTVKLLFKLHSCLPADTLQGHRDRFMEQFTKLKDLFYRSSNLQYFKRLIQIPQLPENPPNFLRASALSEHISPVVVIPAEASSPDSEPVLEKDDLMDMDASQQNLFDNKFDDIFGSSFSSDPFNFNSQNGVNKDEKDHLIERLYREISGLKAQLENMKTESQRVVLQLKGHVSELEADLAEQQHLRQQAADDCEFLRAELDELRRQREDTEKAQRSLSEIERKAQANEQRYSKLKEKYSELVQNHADLLRKNAEVTKQVSMARQAQVDLEREKKELEDSLERISDQGQRKTQEQLEVLESLKQELATSQRELQVLQGSLETSAQSEANWAAEFAELEKERDSLVSGAAHREEELSALRKELQDTQLKLASTEESMCQLAKDQRKMLLVGSRKAAEQVIQDALNQLEEPPLISCAGSADHLLSTVTSISSCIEQLEKSWSQYLACPEDISGLLHSITLLAHLTSDAIAHGATTCLRAPPEPADSLTEACKQYGRETLAYLASLEEEGSLENADSTAMRNCLSKIKAIGEELLPRGLDIKQEELGDLVDKEMAATSAAIETATARIEEMLSKSRAGDTGVKLEVNERILGCCTSLMQAIQVLIVASKDLQREIVESGRGTASPKEFYAKNSRWTEGLISASKAVGWGATVMVDAADLVVQGRGKFEELMVCSHEIAASTAQLVAASKVKADKDSPNLAQLQQASRGVNQATAGVVASTISGKSQIEETDNMDFSSMTLTQIKRQEMDSQVRVLELENELQKERQKLGELRKKHYELAGVAEGWEEGTEASPPTLQEVVTEKE
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). Translocation t(5;7)(q33;q11.2) with PDGFRB (PubMed:9616134). The chimeric HIP1-PDGFRB transcript results from an in-frame fusion of the two genes (PubMed:9616134). The reciprocal PDGFRB-HIP1 transcript is not expressed (PubMed:9616134). {ECO:0000269|PubMed:9616134}.
uniprot
proteins
function
FUNCTION: Plays a role in clathrin-mediated endocytosis and trafficking (PubMed:11532990, PubMed:11577110, PubMed:11889126). Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity). Regulates presynaptic nerve terminal activity (By similarity). Enhances androgen receptor (AR)-mediated transcription (PubMed:16027218). May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway (PubMed:11007801). Binds 3-phosphoinositides (via ENTH domain) (PubMed:14732715). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis (PubMed:14732715). May play a functional role in the cell filament networks (PubMed:18790740). May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors (PubMed:11007801, PubMed:12163454). {ECO:0000250|UniProtKB:Q8VD75, ECO:0000269|PubMed:11007801, ECO:0000269|PubMed:11532990, ECO:0000269|PubMed:11577110, ECO:0000269|PubMed:11889126, ECO:0000269|PubMed:12163454, ECO:0000269|PubMed:14732715, ECO:0000269|PubMed:16027218, ECO:0000269|PubMed:18790740, ECO:0000269|PubMed:9147654}.
uniprot
proteins
mass_dalton
116221
uniprot
proteins
mutagenesis
MUTAGEN 56; /note="K->E: Abolishes 3-phosphoinositide-binding; when associated with E-58."; /evidence="ECO:0000269|PubMed:16027218"; MUTAGEN 58; /note="K->E: Abolishes 3-phosphoinositide-binding; when associated with E-56."; /evidence="ECO:0000269|PubMed:16027218"; MUTAGEN 432; /note="F->G: Abolishes HIP1-induced cell death."; /evidence="ECO:0000269|PubMed:11007801"; MUTAGEN 1005; /note="R->E: Reduces AR-induced nuclear translocation."; /evidence="ECO:0000269|PubMed:16027218
uniprot
proteins
protein_family
SLA2 family
uniprot
proteins
pubmed
11007801
uniprot
proteins
pubmed
11063258
uniprot
proteins
pubmed
11517213
uniprot
proteins
pubmed
11532990
uniprot
proteins
pubmed
11577110
uniprot
proteins
pubmed
11788820
uniprot
proteins
pubmed
11889126
uniprot
proteins
pubmed
12163454
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14732715
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15533940
uniprot
proteins
pubmed
16027218
uniprot
proteins
pubmed
17257618
uniprot
proteins
pubmed
18155047
uniprot
proteins
pubmed
18790740
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
9140394
uniprot
proteins
pubmed
9147654
uniprot
proteins
pubmed
9616134
uniprot
proteins
sequence_length
1037
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note=Shuttles between cytoplasm and nucleus. Nuclear translocation can be induced by AR.
uniprot
proteins