DBF4B
entrez
80174
canonical
uniprot
Q8NFT6
canonical
ensembl
ENSG00000161692
resolver
ensp
ENSP00000323663
resolver
ensp
ENSP00000377178
resolver
ensp
ENSP00000735302
resolver
ensp
ENSP00000735303
resolver
ensp
ENSP00000735305
resolver
genesymbol
DBF4B
resolver
genesymbol_syn
ASKL1
resolver
genesymbol_syn
DRF1
resolver
hgnc
HGNC:17883
resolver
uniprot
D3DX56
resolver
uniprot
Q8TEX0
resolver
uniprot
Q96B19
resolver
uniprot
Q9H912
resolver
uniprot_entry
DBF4B_HUMAN
resolver
uniprot_sec
D3DX56
resolver
uniprot_sec
Q8TEX0
resolver
uniprot_sec
Q96B19
resolver
uniprot_sec
Q9H912
resolver
amino_acid_sequence
MSEPGKGDDCLELESSMAESRLRAPDLGVSRCLGKCQKNSPGARKHPFSGKSFYLDLPAGKNLQFLTGAIQQLGGVIEGFLSKEVSYIVSSRREVKAESSGKSHRGCPSPSPSEVRVETSAMVDPKGSHPRPSRKPVDSVPLSRGKELLQKAIRNQGSISGGGSGGSSSLLTNARSWGVRILHVDEMMMHVQQLSLASLCVKKQQPKKPEGTCPAAESRTRKVARLKAPFLKIEDESRKFRPFHHQFKSFPEISFLGPKDASPFEAPTTLGSMHHTRESKDGEPSPRSAAHTMPRRKKGYCECCQEAFEELHVHLQSAQHRSFALEAHLYAEVDRIIAQLSHSFADIPFQAGLPRWSGSPASDCDPLCPETLHPHQPSHPRAASPRIRKEDSCQASVTQGRAAGQQRWTESLDGVMGPPASHTCVSATTLLPALPKGSREQGCLCPCPASFTQSHLVTSLALLPGEWSPAEDMPLHPSQENSFAPADIPVKGPLLFPEARPWLMSARCWVRPFPFVTWGCLIPHDTTPLHEEVSPCPCLRLGYLYLLLTQSLWCRVRVPSLSTAGPIPRTSHPCTLAFPSYLNDHDLGHLCQAKPQGWNTPQPFLHCGFLAVDSG
uniprot
proteins
function
FUNCTION: Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:12065429, ECO:0000269|PubMed:15668232, ECO:0000269|PubMed:17062569}.
uniprot
proteins
mass_dalton
67243
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000269|PubMed:12065429}.
uniprot
proteins
pubmed
12065429
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15668232
uniprot
proteins
pubmed
17062569
uniprot
proteins
sequence_length
615
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12065429, ECO:0000269|PubMed:15668232}. Note=Predominantly found in soluble fraction but not in the chromatin-bound fraction.
uniprot
proteins