Nasp
entrez
298441
canonical
uniprot
Q66HD3
canonical
ensembl
ENSRNOG00000016454
resolver
ensembl
ENSRNOG00055013195
resolver
ensembl
ENSRNOG00060028660
resolver
ensembl
ENSRNOG00065016596
resolver
ensp
ENSRNOP00000022170
resolver
ensp
ENSRNOP00000091359
resolver
ensp
ENSRNOP00055018427
resolver
ensp
ENSRNOP00060041788
resolver
ensp
ENSRNOP00065021864
resolver
enst
ENSRNOT00000022170
resolver
enst
ENSRNOT00000119622
resolver
enst
ENSRNOT00055022676
resolver
enst
ENSRNOT00060050147
resolver
enst
ENSRNOT00065027743
resolver
genesymbol
Nasp
resolver
uniprot
A0A8I6AFA6
resolver
uniprot_entry
A0A8I6AFA6_RAT
resolver
uniprot_entry
NASP_RAT
resolver
amino_acid_sequence
MATESTATAAIAAELVSADKVEDAPAPSTSADKMESLDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNVDEEAREELREQVYDAMGEKEAKKAEGQSLTKPETDKEQESEVEKGGREDMDISEPAEKLQEKVESTSKQLTESSEEAKEAAIPGLNEDEVTSGKTEQESLCTEEGKSISGVYVQNKEFREAVPQEEGEEMISLEKKPKETSEDQTIGAPEKQDTLMKVVEIEAEIDSEVKSVDVGGEEPKDQGAISESELGKAVLMQLSGQDVEVSPVVAAEAGSEVSEKPGQEITVLPNNGPVVGQSSAGDQTPSEPQNSAERLSETKDGASVEEVKAELVPEQEEAMPPVEESEAAGDGVETKVAQRATEKAPEDKFKIAANEETQERDEQMKEGEETEGSEEEDKENDKAEETTNESVLEKKTLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYIQAVEEFQACLSLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFGKSIDVIEKRMAVLLEQMKEAEGSFTEYEKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPSGAGASVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKPEPEVNGGSGDAVSSGNEVSENMEAEAENQAESQTTAEGTVDSAATVKSTAC
uniprot
proteins
function
FUNCTION: Component of the histone chaperone network (By similarity). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (By similarity). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:P49321, ECO:0000250|UniProtKB:Q99MD9}.
uniprot
proteins
mass_dalton
84200
uniprot
proteins
protein_family
NASP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
776
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99MD9}. Nucleus {ECO:0000250|UniProtKB:Q99MD9}.
uniprot
proteins