Sbds
entrez
66711
canonical
uniprot
P70122
canonical
ensembl
ENSMUSG00000025337
resolver
ensp
ENSMUSP00000026387
resolver
enst
ENSMUST00000026387
resolver
genesymbol
Sbds
resolver
uniprot
Q3TG78
resolver
uniprot
Q9CR18
resolver
uniprot_entry
SBDS_MOUSE
resolver
uniprot_sec
Q3TG78
resolver
uniprot_sec
Q9CR18
resolver
amino_acid_sequence
MSIFTPTNQIRLTNVAVVRMKRGGKRFEIACYKNKVVGWRSGVEKDLDEVLQTHSVFVNVSKGQVAKKEDLISAFGTDDQTEICKQILTKGEVQVSDKERHTQLEQMFRDIATIVADKCVNPETKRPYTVILIERAMKDIHYSVKPNKSTKQQALEVIKQLKEKMKIERAHMRLRFILPVNEGKKLKEKLKPLMKVVESEDYSQQLEIVCLIDPGCFREIDELIKKETKGRGSLEVLSLKDVEEGDEKFE
uniprot
proteins
function
FUNCTION: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation (By similarity). {ECO:0000250, ECO:0000269|PubMed:19602484, ECO:0000269|PubMed:21536732}.
uniprot
proteins
mass_dalton
28781
uniprot
proteins
protein_family
SDO1/SBDS family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16914746
uniprot
proteins
pubmed
19602484
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21536732
uniprot
proteins
sequence_length
250
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleolus {ECO:0000250}. Nucleus, nucleoplasm. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Detected in the cytoplasm, but not in the nucleus (PubMed:21536732). Primarily detected in the cytoplasm, and at low levels in nucleus (PubMed:19602484). Detected in the nucleolus during G1 and G2 phase of the cell cycle, and diffusely distributed in the nucleus during S phase. Detected at the mitotic spindle. Colocalizes with the microtubule organizing center during interphase (By similarity). {ECO:0000250, ECO:0000269|PubMed:19602484, ECO:0000269|PubMed:21536732}.
uniprot
proteins