NCOR2
entrez
9612
canonical
uniprot
Q9Y618
canonical
ensembl
ENSG00000196498
resolver
ensp
ENSP00000384018
resolver
ensp
ENSP00000384202
resolver
ensp
ENSP00000400281
resolver
enst
ENST00000404621
resolver
enst
ENST00000429285
resolver
genesymbol
NCOR2
resolver
genesymbol_syn
CTG26
resolver
hgnc
HGNC:7673
resolver
uniprot
C9J0Q5
resolver
uniprot
C9JE98
resolver
uniprot
O00613
resolver
uniprot
O15416
resolver
uniprot
O15421
resolver
uniprot
Q13354
resolver
uniprot
Q56D06
resolver
uniprot
Q59GM0
resolver
uniprot
Q9Y5U0
resolver
uniprot_entry
C9J0Q5_HUMAN
resolver
uniprot_entry
C9JE98_HUMAN
resolver
uniprot_entry
NCOR2_HUMAN
resolver
uniprot_sec
O00613
resolver
uniprot_sec
O15416
resolver
uniprot_sec
O15421
resolver
uniprot_sec
Q13354
resolver
uniprot_sec
Q56D06
resolver
uniprot_sec
Q59GM0
resolver
uniprot_sec
Q9Y5U0
resolver
amino_acid_sequence
MSGSTQPVAQTWRATEPRYPPHSLSYPVQIARTHTDVGLLEYQHHSRDYASHLSPGSIIQPQRRRPSLLSEFQPGNERSQELHLRPESHSYLPELGKSEMEFIESKRPRLELLPDPLLRPSPLLATGQPAGSEDLTKDRSLTGKLEPVSPPSPPHTDPELELVPPRLSKEELIQNMDRVDREITMVEQQISKLKKKQQQLEEEAAKPPEPEKPVSPPPIESKHRSLVQIIYDENRKKAEAAHRILEGLGPQVELPLYNQPSDTRQYHENIKINQAMRKKLILYFKRRNHARKQWEQKFCQRYDQLMEAWEKKVERIENNPRRRAKESKVREYYEKQFPEIRKQRELQERMQSRVGQRGSGLSMSAARSEHEVSEIIDGLSEQENLEKQMRQLAVIPPMLYDADQQRIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLIASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQQQQQQQQQQQQQPMPRSSQEEKDEKEKEKEAEKEEEKPEVENDKEDLLKEKTDDTSGEDNDEKEAVASKGRKTANSQGRRKGRITRSMANEANSEEAITPQQSAELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMVGSKTVSQCKNFYFNYKKRQNLDEILQQHKLKMEKERNARRKKKKAPAAASEEAAFPPVVEDEEMEASGVSGNEEEMVEEAEALHASGNEVPRGECSGPATVNNSSDTESIPSPHTEAAKDTGQNGPKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRSPAPPADKEAFAAEAQKLPGDPPCWTSGLPFPVPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFSGVKQEQLSPRGQAGPPESLGVPTAQEASVLRGTALGSVPGGSITKGIPSTRVPSDSAITYRGSITHGTPADVLYKGTITRIIGEDSPSRLDRGREDSLPKGHVIYEGKKGHVLSYEGGMSVTQCSKEDGRSSSGPPHETAAPKRTYDMMEGRVGRAISSASIEGLMGRAIPPERHSPHHLKEQHHIRGSITQGIPRSYVEAQEDYLRREAKLLKREGTPPPPPPSRDLTEAYKTQALGPLKLKPAHEGLVATVKEAGRSIHEIPREELRHTPELPLAPRPLKEGSITQGTPLKYDTGASTTGSKKHDVRSLIGSPGRTFPPVHPLDVMADARALERACYEESLKSRPGTASSSGGSIARGAPVIVPELGKPRQSPLTYEDHGAPFAGHLPRGSPVTTREPTPRLQEGSLSSSKASQDRKLTSTPREIAKSPHSTVPEHHPHPISPYEHLLRGVSGVDLYRSHIPLAFDPTSIPRGIPLDAAAAYYLPRHLAPNPTYPHLYPPYLIRGYPDTAALENRQTIINDYITSQQMHHNAATAMAQRADMLRGLSPRESSLALNYAAGPRGIIDLSQVPHLPVLVPPTPGTPATAMDRLAYLPTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDREREKSILTSTTTVEHAPIWRPGTEQSSGSSGGGGGSSSRPASHSHAHQHSPISPRTQDALQQRPSVLHNTGMKGIITAVEPSTPTVLRSTSTSSPVRPAATFPPATHCPLGGTLDGVYPTLMEPVLLPKEAPRVARPERPRADTGHAFLAKPPARSGLEPASSPSKGSEPRPLVPPVSGHATIARTPAKNLAPHHASPDPPAPPASASDPHREKTQSKPFSIQELELRSLGYHGSSYSPEGVEPVSPVSSPSLTHDKGLPKHLEELDKSHLEGELRPKQPGPVKLGGEAAHLPHLRPLPESQPSSSPLLQTAPGVKGHQRVVTLAQHISEVITQDYTRHHPQQLSAPLPAPLYSFPGASCPVLDLRRPPSDLYLPPPDHGAPARGSPHSEGGKRSPEPNKTSVLGGGEDGIEPVSPPEGMTEPGHSRSAVYPLLYRDGEQTEPSRMGSKSPGNTSQPPAFFSKLTESNSAMVKSKKQEINKKLNTHNRNEPEYNISQPGTEIFNMPAITGTGLMTYRSQAVQEHASTNMGLEAIIRKALMGKYDQWEESPPLSANAFNPLNASASLPAAMPITAADGRSDHTLTSPGGGGKAKVSGRPSSRKAKSPAPGLASGDRPPSVSSVHSEGDCNRRTPLTNRVWEDRPSSAGSTPFPYNPLIMRLQAGVMASPPPPGLPAGSGPLAGPHHAWDEEPKPLLCSQYETLSDSE
uniprot
proteins
function
FUNCTION: Transcriptional corepressor that mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription (PubMed:10077563, PubMed:10097068, PubMed:18212045, PubMed:20812024, PubMed:22230954, PubMed:23911289). Acts by recruiting chromatin modifiers, such as histone deacetylases HDAC1, HDAC2 and HDAC3 (PubMed:22230954). Required to activate the histone deacetylase activity of HDAC3 (PubMed:22230954). Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival (PubMed:18212045, PubMed:23911289). Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). {ECO:0000269|PubMed:10077563, ECO:0000269|PubMed:10097068, ECO:0000269|PubMed:18212045, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:22230954, ECO:0000269|PubMed:23911289}.; FUNCTION: [Isoform 1]: Isoform 1 and isoform 4 have different affinities for different nuclear receptors. {ECO:0000269|PubMed:15632172}.; FUNCTION: [Isoform 4]: Isoform 1 and isoform 4 have different affinities for different nuclear receptors. {ECO:0000269|PubMed:15632172}.
uniprot
proteins
mass_dalton
273657
uniprot
proteins
mutagenesis
MUTAGEN 242..245; /note="HRIL->AEIA: Abolishes interaction with TBL1X."; /evidence="ECO:0000269|PubMed:21240272"; MUTAGEN 2128; /note="R->A: Abolishes interaction with the apo LBD of RARA. Restores some interaction on the addition of inverse agonist BMS493."; /evidence="ECO:0000269|PubMed:20543827"; MUTAGEN 2130; /note="V->P: Abolishes interaction with the apo LBD of RARA. No change on interaction on the addition of inverse agonist BMS493."; /evidence="ECO:0000269|PubMed:20543827"; MUTAGEN 2131; /note="T->G: Abolishes interaction with the apo LBD of RARA. Restores some interaction on the addition of inverse agonist BMS493."; /evidence="ECO:0000269|PubMed:20543827
uniprot
proteins
protein_family
N-CoR nuclear receptor corepressors family
uniprot
proteins
pubmed
10077563
uniprot
proteins
pubmed
10097068
uniprot
proteins
pubmed
10809664
uniprot
proteins
pubmed
10944117
uniprot
proteins
pubmed
11331609
uniprot
proteins
pubmed
11533236
uniprot
proteins
pubmed
11739383
uniprot
proteins
pubmed
11931768
uniprot
proteins
pubmed
12554770
uniprot
proteins
pubmed
14690607
uniprot
proteins
pubmed
15454082
uniprot
proteins
pubmed
15632172
uniprot
proteins
pubmed
16121196
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18212045
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19786558
uniprot
proteins
pubmed
19858209
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20543827
uniprot
proteins
pubmed
20812024
uniprot
proteins
pubmed
21240272
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22230954
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23372760
uniprot
proteins
pubmed
23911289
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
30341416
uniprot
proteins
pubmed
7566127
uniprot
proteins
pubmed
8813722
uniprot
proteins
pubmed
9225980
uniprot
proteins
sequence_length
2514
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10097068}.
uniprot
proteins