Sox5
entrez
20678
canonical
uniprot
P35710
canonical
ensembl
ENSMUSG00000041540
resolver
ensp
ENSMUSP00000047567
resolver
ensp
ENSMUSP00000076403
resolver
ensp
ENSMUSP00000107377
resolver
ensp
ENSMUSP00000107378
resolver
ensp
ENSMUSP00000133041
resolver
ensp
ENSMUSP00000200591
resolver
ensp
ENSMUSP00000200593
resolver
ensp
ENSMUSP00000200600
resolver
ensp
ENSMUSP00000200601
resolver
enst
ENSMUST00000038815
resolver
enst
ENSMUST00000077160
resolver
enst
ENSMUST00000111749
resolver
enst
ENSMUST00000170367
resolver
genesymbol
Sox5
resolver
genesymbol_syn
Sox-5
resolver
uniprot
B2KFM4
resolver
uniprot
B2KFM9
resolver
uniprot
E9PVR0
resolver
uniprot
F7CX90
resolver
uniprot
O88184
resolver
uniprot
O89018
resolver
uniprot
Q2TBA9
resolver
uniprot
Q3TVF9
resolver
uniprot
Q8C4K8
resolver
uniprot_entry
B2KFM4_MOUSE
resolver
uniprot_entry
B2KFM9_MOUSE
resolver
uniprot_entry
E9PVR0_MOUSE
resolver
uniprot_entry
F7CX90_MOUSE
resolver
uniprot_entry
Q2TBA9_MOUSE
resolver
uniprot_entry
Q3TVF9_MOUSE
resolver
uniprot_entry
Q8C4K8_MOUSE
resolver
uniprot_entry
SOX5_MOUSE
resolver
uniprot_sec
O88184
resolver
uniprot_sec
O89018
resolver
amino_acid_sequence
MLTDPDLPQEFERMSSKRPASPYGETDGEVAMVTSRQKVEEEESERLPAFHLPLHVSFPNKPHSEEFQPVSLLTQETCGPRTPTVQHNTMEVDGNKVMSSLSPYNSSTSPQKAEEGGRQSGESVSSAALGTPERRKGSLADVVDTLKQRKMEELIKNEPEDTPSIEKLLSKDWKDKLLAMGSGNFGEIKGTPESLAEKERQLMGMINQLTSLREQLLAAHDEQKKLAASQIEKQRQQMELAKQQQEQIARQQQQLLQQQHKINLLQQQIQVQGQLPPLMIPVFPPDQRTLAAAAQQGFLLPPGFSYKAGCSDPYPVQLIPTTMAAAAAATPGLGPLQLQQFYAAQLAAMQVSPGGKLLGLPQGNLGAAVSPTSIHTDKSTNSPPPKSKDEVAQPLNLSAKPKTSDGKSPASPTSPHMPALRINSGAGPLKASVPAALASPSARVSTIGYLNDHDAVTKAIQEARQMKEQLRREQQALDGKVAVVNSIGLSNCRTEKEKTTLESLTQQLAVKQNEEGKFSHGMMDFNMSGDSDGSAGVSESRIYRESRGRGSNEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKAMTNLEKQPYYEEQARLSKQHLEKYPDYKYKPRPKRTCLVDGKKLRIGEYKAIMRNRRQEMRQYFNVGQQAQIPIATAGVVYPSAIAMAGMPSPHLPSEHSSVSSSPEPGMPVIQSTYGAKGEEPHIKEEIQAEDINGEIYEEYDEEEEDPDVDYGSDSENHIAGQAN
uniprot
proteins
function
FUNCTION: Transcription factor involved in chondrocytes differentiation and cartilage formation (PubMed:11702786, PubMed:1396566, PubMed:14993235, PubMed:15529345, PubMed:8078769). Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes, such as COL2A1 and AGC1 (PubMed:11702786, PubMed:26150426, PubMed:9755172). Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate (PubMed:11702786, PubMed:14993235, PubMed:15529345, PubMed:26150426). Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes (PubMed:14993235). Together with SOX6, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts (PubMed:14993235). Binds to the proximal promoter region of the myelin protein MPZ gene (PubMed:26525805). {ECO:0000269|PubMed:11702786, ECO:0000269|PubMed:1396566, ECO:0000269|PubMed:14993235, ECO:0000269|PubMed:15529345, ECO:0000269|PubMed:26150426, ECO:0000269|PubMed:26525805, ECO:0000269|PubMed:8078769, ECO:0000269|PubMed:9755172}.
uniprot
proteins
mass_dalton
84090
uniprot
proteins
pubmed
11266597
uniprot
proteins
pubmed
11702786
uniprot
proteins
pubmed
12414734
uniprot
proteins
pubmed
1396566
uniprot
proteins
pubmed
14993235
uniprot
proteins
pubmed
15529345
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26150426
uniprot
proteins
pubmed
26525805
uniprot
proteins
pubmed
27923061
uniprot
proteins
pubmed
8078769
uniprot
proteins
pubmed
9714725
uniprot
proteins
pubmed
9755172
uniprot
proteins
sequence_length
763
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9755172}.
uniprot
proteins