H2AC7
entrez
3013
canonical
uniprot
P20671
canonical
ensembl
ENSG00000196866
resolver
ensp
ENSP00000341094
resolver
enst
ENST00000341023
resolver
genesymbol
H2AC7
resolver
genesymbol_syn
H2AFG
resolver
genesymbol_syn
HIST1H2AD
resolver
hgnc
HGNC:4729
resolver
uniprot
A0PK91
resolver
uniprot
B2R5B6
resolver
uniprot
P57754
resolver
uniprot
Q6FGY6
resolver
uniprot_entry
B2R5B6_HUMAN
resolver
uniprot_entry
H2A1D_HUMAN
resolver
uniprot_sec
A0PK91
resolver
uniprot_sec
P57754
resolver
uniprot_sec
Q6FGY6
resolver
amino_acid_sequence
MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGKVTIAQGGVLPNIQAVLLPKKTESHHKAKGK
uniprot
proteins
function
FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
uniprot
proteins
mass_dalton
14107
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="S->A: Blocks the inhibition of transcription by RPS6KA5/MSK1."; /evidence="ECO:0000269|PubMed:15010469
uniprot
proteins
post_translational_modification
PTM: Deiminated on Arg-4 in granulocytes upon calcium entry. {ECO:0000269|PubMed:15823041}.; PTM: Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Monoubiquitination of Lys-120 (H2AK119Ub) by TRIM37 may promote transformation of cells in a number of breast cancers (PubMed:25470042). Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (PubMed:27083998). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events. {ECO:0000269|PubMed:15386022, ECO:0000269|PubMed:16359901, ECO:0000269|PubMed:16702407, ECO:0000269|PubMed:18001824, ECO:0000269|PubMed:18001825, ECO:0000269|PubMed:19203578, ECO:0000269|PubMed:19203579, ECO:0000269|PubMed:22713238, ECO:0000269|PubMed:22980979, ECO:0000269|PubMed:24352239, ECO:0000269|PubMed:25470042, ECO:0000269|PubMed:27083998}.; PTM: Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription. {ECO:0000269|PubMed:15010469, ECO:0000269|PubMed:15078818, ECO:0000269|PubMed:15823041, ECO:0000269|PubMed:16457589, ECO:0000269|PubMed:24140421}.; PTM: Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex (PubMed:24352239). {ECO:0000269|PubMed:24352239}.; PTM: Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage. {ECO:0000250|UniProtKB:P22752}.; PTM: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. {ECO:0000269|PubMed:21925322}.; PTM: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. {ECO:0000250|UniProtKB:P0C0S5}.
uniprot
proteins
protein_family
Histone H2A family
uniprot
proteins
pubmed
12408966
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15010469
uniprot
proteins
pubmed
15078818
uniprot
proteins
pubmed
15386022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15823041
uniprot
proteins
pubmed
16359901
uniprot
proteins
pubmed
16457589
uniprot
proteins
pubmed
16702407
uniprot
proteins
pubmed
18001824
uniprot
proteins
pubmed
18001825
uniprot
proteins
pubmed
19203578
uniprot
proteins
pubmed
19203579
uniprot
proteins
pubmed
21925322
uniprot
proteins
pubmed
22389435
uniprot
proteins
pubmed
22713238
uniprot
proteins
pubmed
22980979
uniprot
proteins
pubmed
24140421
uniprot
proteins
pubmed
24352239
uniprot
proteins
pubmed
24681537
uniprot
proteins
pubmed
25470042
uniprot
proteins
pubmed
2587222
uniprot
proteins
pubmed
27083998
uniprot
proteins
pubmed
27105115
uniprot
proteins
pubmed
30154464
uniprot
proteins
pubmed
31542297
uniprot
proteins
pubmed
34545082
uniprot
proteins
pubmed
34961760
uniprot
proteins
pubmed
9119399
uniprot
proteins
sequence_length
130
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Chromosome.
uniprot
proteins