Tdp2
entrez
498749
canonical
uniprot
Q3T1H5
canonical
ensembl
ENSRNOG00000018246
resolver
ensembl
ENSRNOG00065022627
resolver
ensp
ENSRNOP00000056326
resolver
ensp
ENSRNOP00065031349
resolver
enst
ENSRNOT00065038642
resolver
genesymbol
Tdp2
resolver
genesymbol_syn
Ttrap
resolver
uniprot_entry
TYDP2_RAT
resolver
amino_acid_sequence
MASGSSSDAAESAEPAAAPAAAETEEDQVKRRRLQSLGFALVTSCDTTVASTFLSENNWQTKKALSAFFEQPENDLARPHQPPTSSKSEDYVDLTNEDANDTTILETSPSGTPLEDSSTISFITWNIDGLDGCNLPERARGVCSCLALYSPDVVFLQEVIPSYCAYLRKRARTYNIITGNEEGYFTAILLKKGRVKFKGQEIIPFPNTKMMRNLLCVNVSLGGNEFCLMTSHLESTRKHSAERINQLKTVFQKMQEATDSTTVIFAGDTNLRDQEVIKCGGLPDNVFDAWEFLGKPKHCRYTWDTKANDNLRIPAACKHRFDRIFFRAEEGHLIPQSLDLIGLERLDCGRFPSDHWGLLCTLNVVL
uniprot
proteins
ec_number
3.1.4.-
uniprot
proteins
function
FUNCTION: DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DNA double-strand breaks/DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. Thereby, protects the transcription of many genes involved in neurological development and maintenance from the abortive activity of TOP2. Hydrolyzes 5'-phosphoglycolates on protruding 5' ends on DSBs due to DNA damage by radiation and free radicals. Has preference for single-stranded DNA or duplex DNA with a 4 base pair overhang as substrate. Also has 3'-tyrosyl DNA phosphodiesterase activity, but less efficiently and much slower than TDP1. Constitutes the major if not only 5'-tyrosyl-DNA phosphodiesterase in cells. Also acts as an adapter by participating in the specific activation of MAP3K7/TAK1 in response to TGF-beta: associates with components of the TGF-beta receptor-TRAF6-TAK1 signaling module and promotes their ubiquitination dependent complex formation. Involved in non-canonical TGF-beta induced signaling routes. May also act as a negative regulator of ETS1 and may inhibit NF-kappa-B activation. Acts as a regulator of ribosome biogenesis following stress. {ECO:0000250|UniProtKB:O95551}.
uniprot
proteins
mass_dalton
40793
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by TRAF6. {ECO:0000250|UniProtKB:O95551}.
uniprot
proteins
protein_family
CCR4/nocturin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
366
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O95551}. Nucleus, PML body {ECO:0000250|UniProtKB:O95551}. Nucleus, nucleolus {ECO:0000250|UniProtKB:O95551}. Cytoplasm {ECO:0000250|UniProtKB:O95551}. Note=Localizes to nucleolar cavities following stress; localization to nucleolus is dependent on PML protein. {ECO:0000250|UniProtKB:O95551}.
uniprot
proteins