Nt5c2
entrez
76952
canonical
uniprot
Q3V1L4
canonical
ensembl
ENSMUSG00000025041
resolver
ensp
ENSMUSP00000129126
resolver
ensp
ENSMUSP00000130898
resolver
ensp
ENSMUSP00000157802
resolver
ensp
ENSMUSP00000158280
resolver
ensp
ENSMUSP00000158576
resolver
ensp
ENSMUSP00000240500
resolver
enst
ENSMUST00000168536
resolver
enst
ENSMUST00000172239
resolver
enst
ENSMUST00000235234
resolver
enst
ENSMUST00000236501
resolver
genesymbol
Nt5c2
resolver
uniprot
A0A494B9X3
resolver
uniprot
E9Q9M1
resolver
uniprot
Q6P223
resolver
uniprot
Q8BZ43
resolver
uniprot
Q9D8G6
resolver
uniprot_entry
5NTC_MOUSE
resolver
uniprot_entry
A0A494B9X3_MOUSE
resolver
uniprot_entry
E9Q9M1_MOUSE
resolver
uniprot_sec
Q6P223
resolver
uniprot_sec
Q8BZ43
resolver
uniprot_sec
Q9D8G6
resolver
activity_regulation
ACTIVITY REGULATION: Allosterically activated by various compounds including ATP, 2,3-BPG/2,3-Bisphosphoglyceric acid and Ap4A/P1,P4-bis(5'-adenosyl) tetraphosphate. Binding of an allosteric activator is a prerequisiste to magnesium and substrate binding. Inhibited by inorganic phosphate. {ECO:0000250|UniProtKB:P49902}.
uniprot
proteins
amino_acid_sequence
MTTSWSDRLQNAADVPANMDKHALKKYRREAYHRVFVNRSLAMEKIKCFGFDMDYTLAVYKSPEYESLGFELTVERLVSIGYPQELLSFAYDSTFPTRGLVFDTLYGNLLKVDAYGNLLVCAHGFNFIRGPETREQYPNKFIQRDDTERFYILNTLFNLPETYLLACLVDFFTNCPRYTSCDTGFKDGDLFMSYRSMFQDVRDAVDWVHYKGSLKEKTVENLEKYVVKDGKLPLLLSRMKEVGKVFLATNSDYKYTDKIMTYLFDFPHGPKPGSSHRPWQSYFDLILVDARKPLFFGEGTVLRQVDTKTGKLKIGTYTGPLQHGIVYSGGSSDTICDLLGAKGKDILYIGDHIFGDILKSKKRQGWRTFLVIPELAQELHVWTDKSSLFEELQSLDIFLAELYKHLDSSSNERPDISSIQRRIKKVTHDMDMCYGMMGSLFRSGSRQTLFASQVMRYADLYAASFINLLYYPFSYLFRAAHVLMPHESTVEHTHVDINEMESPLATRNRTSVDFKDTDYKRHQLTRSISEIKPPNLFPLAPQEITHCHDEDDDEEEEEEE
uniprot
proteins
ec_number
2.7.1.77
uniprot
proteins
ec_number
3.1.3.5
uniprot
proteins
ec_number
3.1.3.99
uniprot
proteins
function
FUNCTION: Broad specificity cytosolic 5'-nucleotidase that catalyzes the dephosphorylation of 6-hydroxypurine nucleoside 5'-monophosphates. In addition, possesses a phosphotransferase activity by which it can transfer a phosphate from a donor nucleoside monophosphate to an acceptor nucleoside, preferably inosine, deoxyinosine and guanosine. Has the highest activities for IMP and GMP followed by dIMP, dGMP and XMP. Could also catalyze the transfer of phosphates from pyrimidine monophosphates but with lower efficiency. Through these activities regulates the purine nucleoside/nucleotide pools within the cell. {ECO:0000250|UniProtKB:P49902}.
uniprot
proteins
mass_dalton
64809
uniprot
proteins
protein_family
5'(3')-deoxyribonucleotidase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
560
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P49902}.
uniprot
proteins