LINGO1
entrez
84894
canonical
uniprot
Q96FE5
canonical
ensembl
ENSG00000169783
resolver
ensp
ENSP00000347451
resolver
ensp
ENSP00000453853
resolver
genesymbol
LINGO1
resolver
genesymbol_syn
LERN1
resolver
genesymbol_syn
LRRN6A
resolver
hgnc
HGNC:21205
resolver
uniprot
D3DW80
resolver
uniprot
Q6NUK3
resolver
uniprot
Q6UXM3
resolver
uniprot
Q6VVG0
resolver
uniprot
Q6VVG1
resolver
uniprot
Q6VVG2
resolver
uniprot
Q8N3K5
resolver
uniprot
Q96K52
resolver
uniprot_entry
LIGO1_HUMAN
resolver
uniprot_sec
D3DW80
resolver
uniprot_sec
Q6NUK3
resolver
uniprot_sec
Q6UXM3
resolver
uniprot_sec
Q6VVG0
resolver
uniprot_sec
Q6VVG1
resolver
uniprot_sec
Q6VVG2
resolver
uniprot_sec
Q8N3K5
resolver
uniprot_sec
Q96K52
resolver
amino_acid_sequence
MQVSKRMLAGGVRSMPSPLLACWQPILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTETRLLDLGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGLNLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEESVFHSVGNLETLILDSNPLACDCRLLWVFRRRWRLNFNRQQPTCATPEFVQGKEFKDFPDVLLPNYFTCRRARIRDRKAQQVFVDEGHTVQFVCRADGDPPPAILWLSPRKHLVSAKSNGRLTVFPDGTLEVRYAQVQDNGTYLCIAANAGGNDSMPAHLHVRSYSPDWPHQPNKTFAFISNQPGEGEANSTRATVPFPFDIKTLIIATTMGFISFLGVVLFCLVLLFLWSRGKGNTKHNIEIEYVPRKSDAGISSADAPRKFNMKMI
uniprot
proteins
disease_involvement
DISEASE: Intellectual developmental disorder, autosomal recessive 64 (MRT64) [MIM:618103]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT64 patients have moderate to severe intellectual disability, delayed motor development, aggressive behavior, and slurred or absent speech. {ECO:0000269|PubMed:28837161}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors (PubMed:14966521, PubMed:15694321). Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination (PubMed:15895088). Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development (By similarity). {ECO:0000250|UniProtKB:Q9D1T0, ECO:0000269|PubMed:14966521, ECO:0000269|PubMed:15694321, ECO:0000269|PubMed:15895088}.
uniprot
proteins
mass_dalton
69876
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. Contains predominantly high-mannose glycans. {ECO:0000269|PubMed:17005555}.
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14686891
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14966521
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15694321
uniprot
proteins
pubmed
15895088
uniprot
proteins
pubmed
17005555
uniprot
proteins
pubmed
17726113
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19052207
uniprot
proteins
pubmed
28837161
uniprot
proteins
sequence_length
620
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9D1T0}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9D1T0}.
uniprot
proteins
transmembrane_region
TRANSMEM 562..582; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins