IL22
entrez
50616
canonical
uniprot
Q9GZX6
canonical
ensembl
ENSG00000127318
resolver
ensp
ENSP00000329384
resolver
ensp
ENSP00000442424
resolver
enst
ENST00000328087
resolver
enst
ENST00000538666
resolver
genesymbol
IL22
resolver
genesymbol_syn
ILTIF
resolver
genesymbol_syn
ZCYTO18
resolver
hgnc
HGNC:14900
resolver
uniprot_entry
IL22_HUMAN
resolver
amino_acid_sequence
MAALQKSVSSFLMGTLATSCLLLLALLVQGGAAAPISSHCRLDKSNFQQPYITNRTFMLAKEASLADNNTDVRLIGEKLFHGVSMSERCYLMKQVLNFTLEEVLFPQSDRFQPYMQEVVPFLARLSNRLSTCHIEGDDLHIQRNVQKLKDTVKKLGESGEIKAIGELDLLFMSLRNACI
uniprot
proteins
function
FUNCTION: Cytokine that plays a critical role in modulating tissue responses during inflammation (PubMed:17204547). Plays an essential role in the regeneration of epithelial cells to maintain barrier function after injury and for the prevention of further tissue damage (PubMed:17204547). Unlike most of the cytokines, has no effect on immune cells. Signals through a heterodimeric receptor composed of two subunits, the specific receptor IL22RA1 which is present on non-immune cells in many organs and the shared subunit IL10RB (PubMed:10875937, PubMed:18599299). Ligation of IL22RA1 with IL22 induces activation of the tyrosine kinases JAK1 and TYK2, which in turn activates STAT3. In turn, promotes cell survival and proliferation through STAT3, ERK1/2 and PI3K/AKT pathways (PubMed:25793261, PubMed:31311100). Promotes phosphorylation of GSK3B at 'Ser-9' and CTTN (By similarity). Promotes epithelial cell spreading (By similarity). {ECO:0000250|UniProtKB:Q9JJY9, ECO:0000269|PubMed:10875937, ECO:0000269|PubMed:17204547, ECO:0000269|PubMed:18599299, ECO:0000269|PubMed:25793261, ECO:0000269|PubMed:31311100}.
uniprot
proteins
mass_dalton
20011
uniprot
proteins
protein_family
IL-10 family
uniprot
proteins
pubmed
10875937
uniprot
proteins
pubmed
10954742
uniprot
proteins
pubmed
11197690
uniprot
proteins
pubmed
11856845
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15983417
uniprot
proteins
pubmed
17204547
uniprot
proteins
pubmed
18599299
uniprot
proteins
pubmed
25793261
uniprot
proteins
pubmed
31311100
uniprot
proteins
sequence_length
179
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins