Pcgf5
entrez
76073
canonical
uniprot
Q3UK78
canonical
ensembl
ENSMUSG00000024805
resolver
ensp
ENSMUSP00000058730
resolver
ensp
ENSMUSP00000071245
resolver
ensp
ENSMUSP00000153206
resolver
ensp
ENSMUSP00000153464
resolver
ensp
ENSMUSP00000237756
resolver
ensp
ENSMUSP00000237768
resolver
ensp
ENSMUSP00000237769
resolver
genesymbol
Pcgf5
resolver
genesymbol_syn
Rnf159
resolver
uniprot
B2RTD3
resolver
uniprot
B7ZP23
resolver
uniprot
Q9D3E5
resolver
uniprot
Q9DCW8
resolver
uniprot_entry
PCGF5_MOUSE
resolver
uniprot_sec
B2RTD3
resolver
uniprot_sec
B7ZP23
resolver
uniprot_sec
Q9D3E5
resolver
uniprot_sec
Q9DCW8
resolver
amino_acid_sequence
MATQRKHLVKDFNPYITCYICKGYLIKPTTVTECLHTFCKTCIVQHFEDSNDCPRCGNQVHETNPLEMLRLDNTLEEIIFKLVPGLREQELQRELEFWKKNKPQENGQDDISKVDKSKADEEGDENQDDKDYHRSDPQIAICLDCLRNNGQSGDNVVKGLMKKFIRCSTRVTVGTIKKFLSLKLKLPSSYELDVLCNGEIMGKDHTMEFIYMTRWRLRGENLCCLNCSASQVCSQDGTLYQSYPMVLQYRPRIDFG
uniprot
proteins
function
FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:27136092, PubMed:28596365). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (By similarity). Plays a redundant role with PCGF3 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (PubMed:28596365). {ECO:0000250|UniProtKB:Q86SE9, ECO:0000269|PubMed:27136092, ECO:0000269|PubMed:28596365}.
uniprot
proteins
mass_dalton
29657
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27136092
uniprot
proteins
pubmed
28596365
uniprot
proteins
sequence_length
256
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28596365}. Nucleus, nucleoplasm {ECO:0000269|PubMed:28596365}. Note=Recruited by the non-coding RNA Xist to specific nuclear foci that probably correspond to the inactivated X chromosome. {ECO:0000269|PubMed:28596365}.
uniprot
proteins