IBRDC1
entrez
154214
canonical
uniprot
Q8TC41
canonical
ensembl
ENSG00000146373
resolver
ensp
ENSP00000352734
resolver
ensp
ENSP00000428698
resolver
ensp
ENSP00000452812
resolver
ensp
ENSP00000657501
resolver
genesymbol
IBRDC1
resolver
genesymbol
RNF217
resolver
genesymbol_syn
C6orf172
resolver
genesymbol_syn
IBRDC1
resolver
genesymbol_syn
OSTL
resolver
hgnc
HGNC:21487
resolver
uniprot
B3KVC8
resolver
uniprot
H7C5V4
resolver
uniprot
Q5TCA4
resolver
uniprot
Q9BX48
resolver
uniprot_entry
B3KVC8_HUMAN
resolver
uniprot_entry
RN217_HUMAN
resolver
uniprot_sec
H7C5V4
resolver
uniprot_sec
Q5TCA4
resolver
uniprot_sec
Q9BX48
resolver
amino_acid_sequence
MGEEQSTVSGGGGPQESQTLASGTAGHPEPPRPQGDSARAPPLRAASAEPSGGGCGSDWGCADTSAPEPARSLGPPGWSKSRAPAQPAGLALTGPLNPQTLPLQLELEEEEEEAGDRKEGGDEQQEAPPGEELEPRTRVGAADGLVLDVLGQRRPSLAKRQVFCSVYCVESDLPEAPASEQLSPPASPPGAPPVLNPPSTRSSFPSPRLSLPTDSLSPDGGSIELEFYLAPEPFSMPSLLGAPPYSGLGGVGDPYVPLMVLMCRVCLEDKPIKPLPCCKKAVCEECLKVYLSAQVQLGQVEIKCPITECFEFLEETTVVYNLTHEDSIKYKYFLELGRIDSSTKPCPQCKHFTTFKKKGHIPTPSRSESKYKIQCPTCQFVWCFKCHSPWHEGVNCKEYKKGDKLLRHWASEIEHGQRNAQKCPKCKIHIQRTEGCDHMTCSQCNTNFCYRCGERYRQLRFFGDHTSNLSIFGCKYRYLPERPHLRRLVRGSVCAGKLFIAPLIMVLGLALGAIAVVIGLFVFPIYCLCKKQRKRSRTGMHW
uniprot
proteins
ec_number
2.3.2.31
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the degradation of the iron exporter ferroportin/SLC40A1 and thus regulates iron homeostasis. {ECO:0000250|UniProtKB:D3YYI7}.
uniprot
proteins
mass_dalton
59372
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
RBR family
uniprot
proteins
protein_family
RNF217 subfamily
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
25298122
uniprot
proteins
sequence_length
542
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:25298122}.
uniprot
proteins
transmembrane_region
TRANSMEM 503..523; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins