CD2
entrez
914
canonical
uniprot
P06729
canonical
ensembl
ENSG00000116824
resolver
ensp
ENSP00000358490
resolver
ensp
ENSP00000521390
resolver
enst
ENST00000369478
resolver
genesymbol
CD2
resolver
genesymbol_syn
SRBC
resolver
hgnc
HGNC:1639
resolver
uniprot
Q53F96
resolver
uniprot
Q96TE5
resolver
uniprot_entry
CD2_HUMAN
resolver
uniprot_entry
Q53F96_HUMAN
resolver
uniprot_sec
Q96TE5
resolver
amino_acid_sequence
MSFPCKFVASFLLIFNVSSKGAVSKEITNALETWGALGQDINLDIPSFQMSDDIDDIKWEKTSDKKKIAQFRKEKETFKEKDTYKLFKNGTLKIKHLKTDDQDIYKVSIYDTKGKNVLEKIFDLKIQERVSKPKISWTCINTTLTCEVMNGTDPELNLYQDGKHLKLSQRVITHKWTTSLSAKFKCTAGNKVSKESSVEPVSCPEKGLDIYLIIGICGGGSLLMVFVALLVFYITKRKKQRSRRNDEELETRAHRVATEERGRKPHQIPASTPQNPATSQHPPPPPGHRSQAPSHRPPPPGHRVQHQPQKRPPAPSGTQVHQQKGPPLPRPRVQPKPPHGAAENSLSPSSN
uniprot
proteins
function
FUNCTION: CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function.
uniprot
proteins
mass_dalton
39448
uniprot
proteins
mutagenesis
MUTAGEN 67; /note="K->R: Loss of CD58 binding."; /evidence="ECO:0000269|PubMed:2444890"; MUTAGEN 70; /note="Q->K: Loss of CD58 binding."; /evidence="ECO:0000269|PubMed:2444890"; MUTAGEN 110; /note="Y->D: Loss of CD58 and CD59 binding."; /evidence="ECO:0000269|PubMed:2444890"; MUTAGEN 111; /note="D->H: Loss of CD58 and CD59 binding."; /evidence="ECO:0000269|PubMed:2444890
uniprot
proteins
pubmed
10380930
uniprot
proteins
pubmed
1377404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
23006327
uniprot
proteins
pubmed
2437578
uniprot
proteins
pubmed
2444890
uniprot
proteins
pubmed
2883656
uniprot
proteins
pubmed
2894031
uniprot
proteins
pubmed
2901953
uniprot
proteins
pubmed
3490670
uniprot
proteins
pubmed
7544493
uniprot
proteins
pubmed
7915183
uniprot
proteins
pubmed
7994575
uniprot
proteins
pubmed
9857189
uniprot
proteins
sequence_length
351
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23006327, ECO:0000269|PubMed:2437578}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 210..235; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins