Slc16a12
entrez
309525
canonical
uniprot
D4A734
canonical
ensembl
ENSRNOG00000021916
resolver
ensembl
ENSRNOG00055030231
resolver
ensembl
ENSRNOG00065029968
resolver
ensp
ENSRNOP00000038838
resolver
ensp
ENSRNOP00000104843
resolver
ensp
ENSRNOP00055043373
resolver
ensp
ENSRNOP00065042609
resolver
enst
ENSRNOT00000030024
resolver
enst
ENSRNOT00055052471
resolver
enst
ENSRNOT00065051768
resolver
genesymbol
Slc16a12
resolver
genesymbol_syn
Mct12
resolver
uniprot_entry
MOT12_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Creatine uptake is inhibited by carbonyl cyanide 3-chlorophenylhydrazone (CCCP) and by valinomycin. {ECO:0000250|UniProtKB:Q6ZSM3}.
uniprot
proteins
amino_acid_sequence
MTKITRVGSASPPDGGWGWMIVAGCFLVTICTRAVTRCISIFFVEFQTYFAQDYSQTAWIHSIVDCMTMLCAPLGSVVSNQLSCQAGIMLGGLLASTGLILGSFATSLKHLYLSLGVLTGLGFALCYSPAIAMVGKYFSRRKAFAYGIAMSGSGIGTFILAPVVQLLIEQFSWRGALLILGGFVLNLCVCGALMRPITLKEDPSGPEKSHDRDAQREDCKQASPYSPLTKEWTETRLCCSLQQGYGFLLMSDFVVLAVSVLFMAYGCSPLFVYLVPYALSVGVSHHQAAFLMSILGVIDIVGNITFGWLTDRRCLKNYRYVCYLFAVALDGLCYLCLPMLQSFPLLVPFSCTFGYFDGAYVTLIPVVTAEIVGTTSLSSALGVVYFLHAVPYLVSPPIAGWLVDTTGSYTAAFLLCGFAMIFSSILLGFAKIAKRMKRTQVPFLVKDSDPKLHLWTNGSVAYSIAKELDQKDEESLAKARTGCNLT
uniprot
proteins
function
FUNCTION: Functions as a transporter for creatine and as well for its precursor guanidinoacetate. Transport of creatine and GAA is independent of resting membrane potential and extracellular Na(+), Cl(-), or pH. Contributes to the process of creatine biosynthesis and distribution. {ECO:0000269|PubMed:32781157, ECO:0000269|PubMed:34075817}.
uniprot
proteins
mass_dalton
52840
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Monocarboxylate porter (TC 2.A.1.13) family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
21778275
uniprot
proteins
pubmed
32781157
uniprot
proteins
pubmed
34075817
uniprot
proteins
sequence_length
486
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6ZSM3}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:34075817}; Multi-pass membrane protein {ECO:0000255}. Note=Localized on the sinusoidal membrane of the hepatocyte. Colocalized with SLC6A13 in hepatocytes around the portal vein, (PubMed:34075817). Interaction with isoform 2 of BSG is required for its localization to the plasma membrane (By similarity). {ECO:0000250|UniProtKB:Q6ZSM3, ECO:0000269|PubMed:34075817}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..30; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 58..78; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 86..106; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 115..135; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 148..168; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 177..197; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 253..273; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 289..309; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 320..340; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 353..373; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 383..403; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 410..430; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins