Q9JLH5
uniprot
Q9JLH5
canonical
amino_acid_sequence
MMDSGMEEDVTLPGTLSGCSGLHPVLPSDLDVISDTTGLGNGVLPIMSEEKVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERIQQEFAGPTEHIYKKNIELKVEVESLKRELQERDQLLVKASKAVESLAEGGGSEIQRVKEDARKKVQQVEELLTKRIHLLEEDVKAAQAELEKAFAGTETEKALRLSLESKLSAMKKMQEGDLEMTLALEEKDRLIEELKLSLKSKEALIQCLKEEKSQMASPDENVSSGELRGLSATLREEKERDAEERQKERNHFEERIQALQEDLREKEREIATEKKNSLKRDKAIQGLTMALKSKEKEVEELNSIIKELTADSTQSREAPLKTQVSEFEVRESENCEAALAEKEALLAKLHSENVTKNTENHRLLRNVKKVTQELNDLKKEKLRLERDLEEAHREGNRGARTIHDLRNEVEKLRKEVCEREKAVEKHYKSLPGESSSKFHSQEQVVKGLTESASQEDLLLQKSNEKDLEAIQQNCYLMTAEELKFGSDGLITEKCSQQSPDSKLIFSKEKQQSEYEGLTGDLKTEQNVYAHLAKNLQDTDSKLQAELKRVLALRKQLEQDVLAYRNLQTALQEQLSEIRKREEEPFSFYSDQTSYLSICLEEHSQFQLEHFSQEEIKKKVIDLIQLVKDLHADNQHLKKTIFDISCMGVQGNDRLESTKQAELMASKADEDTLKFKADDENHFQSDQHLEQSREIMEDYAEGGGKDGYVRHMDSNILDHDGAHTPDTSEDHSLEDELLSLLATFFSKKATPSLESRPDLLKALGALLLERICLAEQGSPGDHSDSKAEKALEQVAVRLRDELGHSCLANSFSKSHSELKSPRGTWLVKTGDEAKVELKSVSVQTMTIEDSTRGFKPERKREAWAGKPEEAVFSTELESEALGEMPGLQATHLSFPSAIDKDDQKTGLLIQLKTPELLENLYNLPASQEVVAQLQGQVLELQKELKEYKIRNKQLLDKLILAEAMMEGMAVPNSTPVNVPAAQAVVRTAFQGKPGEQEGHETTHSAGRDKEVDSDQYTSFEIDSEICPPDDLALLPACKENLEDFLGPPSIATYLDSKSQLSVKVSVVGTDQSENINLPDDTEALKQKIHDLQTELEGYRNIIVQLQKHSQCSEAIITVLCGTEGAQDGLNKPKGHIDEEEMTFSSLHQVRYVKHMKILRPLTPEIIDGKMLESLKQQLVEQEQELQKEQDLNLELFGEIHNLQNKFRDLSPSRYDSLVQSQARELSLQRQQIKDSHDICVVCHQHMSTMIKAFEELLQASDVDSCVAEGFREQLTQCAGLLEQLEKLFLHGKSARVEPHTQTELLRRLRTEEDNLPYQHLLPESPEPSASHALSDDEMSEKSFLSREPKPDSETEKYPTIASRFPQDLLMEHIQEIRTLRKHLEESIKTNEKLRKQLERQGCETDQGSTNVSAYSSELHNSLTSEIQFLRKQNEALSTMLEKGSKEKQKENEKLRESLARKTESLEHLQLEYASVREENERLRRDISEKERQNQQLTQEVCSSLQELSRVQEEAKSRQQLLLQKDELLQSLQMELKVYEKLAEEHQKLQQESRGEACGGGQKGQDPFSNLHGLLKEIQVLRDQAERSIQTNNTLKSKLEKQLSQGSKQAQEGALTLAVQALSVTEWSLQLDKHDVNKCPEASDNSFDLFESTQAMAPKSASETPVLSGTDVDSLSCDSTSSATSPSCMPCLVAGRHLWASKSGHHMLCLIEDYDALYKQISWGQTLLAKMDIQTQEALSPTSQKLGPKASFSVPLSKFLSSMNTAKLILEKASRLLKLFWRVSVPTNGQCSLHCDQIGEMKAEITKLHKKLFEQEKKLQNTAKLLQQSKHQEKIIFDQLVITHQVLRKARGNLELRPRAAHPGTSSPSRPGS
uniprot
proteins
function
FUNCTION: Potential regulator of CDK5 activity via its interaction with CDK5R1 (By similarity). Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter (By similarity). Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends (By similarity). Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gTuRC) onto centrosomes (By similarity). In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery (By similarity). Required for the recruitment of AKAP9 to centrosomes (By similarity). Plays a role in neurogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K389, ECO:0000250|UniProtKB:Q96SN8}.
uniprot
proteins
mass_dalton
215482
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in vitro by CDK5. {ECO:0000269|PubMed:10721722}.
uniprot
proteins
pubmed
10721722
uniprot
proteins
pubmed
19553473
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
1903
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q8K389}. Golgi apparatus {ECO:0000250|UniProtKB:Q96SN8}. Cytoplasm {ECO:0000250|UniProtKB:Q96SN8}. Note=Found in the pericentriolar region adhering to the surface of the centrosome and in the region of the centrosomal appendages. Localization to centrosomes versus Golgi apparatus may be cell type-dependent. Due to the probable lack of interaction with EB1/MAPRE1, its localization to microtubule plus ends may not be conserved in rats. {ECO:0000250|UniProtKB:Q96SN8, ECO:0000305|PubMed:19553473}.
uniprot
proteins