ENTPD5
entrez
957
canonical
uniprot
O75356
canonical
ensembl
ENSG00000187097
resolver
ensp
ENSP00000335246
resolver
ensp
ENSP00000451810
resolver
ensp
ENSP00000570932
resolver
ensp
ENSP00000570934
resolver
ensp
ENSP00000570935
resolver
ensp
ENSP00000570936
resolver
ensp
ENSP00000570937
resolver
ensp
ENSP00000570939
resolver
ensp
ENSP00000570941
resolver
ensp
ENSP00000570942
resolver
ensp
ENSP00000570945
resolver
ensp
ENSP00000570946
resolver
ensp
ENSP00000570948
resolver
ensp
ENSP00000570949
resolver
ensp
ENSP00000570951
resolver
ensp
ENSP00000570952
resolver
ensp
ENSP00000570953
resolver
ensp
ENSP00000570954
resolver
ensp
ENSP00000570955
resolver
ensp
ENSP00000570956
resolver
ensp
ENSP00000570958
resolver
ensp
ENSP00000570959
resolver
ensp
ENSP00000570961
resolver
ensp
ENSP00000570962
resolver
ensp
ENSP00000570963
resolver
ensp
ENSP00000570964
resolver
ensp
ENSP00000570965
resolver
ensp
ENSP00000570966
resolver
ensp
ENSP00000570967
resolver
ensp
ENSP00000570972
resolver
ensp
ENSP00000570973
resolver
ensp
ENSP00000570974
resolver
ensp
ENSP00000570978
resolver
ensp
ENSP00000641844
resolver
ensp
ENSP00000651998
resolver
ensp
ENSP00000652002
resolver
ensp
ENSP00000722688
resolver
enst
ENST00000334696
resolver
enst
ENST00000557325
resolver
enst
ENST00000900873
resolver
enst
ENST00000900875
resolver
enst
ENST00000900876
resolver
enst
ENST00000900877
resolver
enst
ENST00000900878
resolver
enst
ENST00000900882
resolver
enst
ENST00000900883
resolver
enst
ENST00000900886
resolver
enst
ENST00000900887
resolver
enst
ENST00000900889
resolver
enst
ENST00000900890
resolver
enst
ENST00000900892
resolver
enst
ENST00000900893
resolver
enst
ENST00000900894
resolver
enst
ENST00000900895
resolver
enst
ENST00000900896
resolver
enst
ENST00000900897
resolver
enst
ENST00000900899
resolver
enst
ENST00000900900
resolver
enst
ENST00000900902
resolver
enst
ENST00000900903
resolver
enst
ENST00000900904
resolver
enst
ENST00000900905
resolver
enst
ENST00000900906
resolver
enst
ENST00000900907
resolver
enst
ENST00000900908
resolver
enst
ENST00000900913
resolver
enst
ENST00000900914
resolver
enst
ENST00000900915
resolver
enst
ENST00000900919
resolver
enst
ENST00000971785
resolver
genesymbol
ENTPD5
resolver
genesymbol_syn
CD39L4
resolver
genesymbol_syn
PCPH
resolver
hgnc
HGNC:3367
resolver
uniprot
A1L4C5
resolver
uniprot
G3V4I0
resolver
uniprot
Q96RX0
resolver
uniprot_entry
ENTP5_HUMAN
resolver
uniprot_entry
G3V4I0_HUMAN
resolver
uniprot_sec
A1L4C5
resolver
uniprot_sec
Q96RX0
resolver
amino_acid_sequence
MATSWGTVFFMLVVSCVCSAVSHRNQQTWFEGIFLSSMCPINVSASTLYGIMFDAGSTGTRIHVYTFVQKMPGQLPILEGEVFDSVKPGLSAFVDQPKQGAETVQGLLEVAKDSIPRSHWKKTPVVLKATAGLRLLPEHKAKALLFEVKEIFRKSPFLVPKGSVSIMDGSDEGILAWVTVNFLTGQLHGHRQETVGTLDLGGASTQITFLPQFEKTLEQTPRGYLTSFEMFNSTYKLYTHSYLGFGLKAARLATLGALETEGTDGHTFRSACLPRWLEAEWIFGGVKYQYGGNQEGEVGFEPCYAEVLRVVRGKLHQPEEVQRGSFYAFSYYYDRAVDTDMIDYEKGGILKVEDFERKAREVCDNLENFTSGSPFLCMDLSYITALLKDGFGFADSTVLQLTKKVNNIETGWALGATFHLLQSLGISH
uniprot
proteins
ec_number
3.6.1.6
uniprot
proteins
function
FUNCTION: Hydrolyzes nucleoside diphosphates with a preference for GDP, IDP and UDP compared to ADP and CDP (PubMed:10400613, PubMed:15698960). In the lumen of the endoplasmic reticulum, hydrolyzes UDP that acts as an end-product feedback inhibitor of the UDP-Glc:glycoprotein glucosyltransferases. UMP can be transported back by an UDP-sugar antiporter to the cytosol where it is consumed to regenerate UDP-glucose. Therefore, it positively regulates protein reglucosylation by clearing UDP from the ER lumen and by promoting the regeneration of UDP-glucose. Protein reglucosylation is essential to proper glycoprotein folding and quality control in the ER (By similarity). {ECO:0000250|UniProtKB:Q9WUZ9, ECO:0000269|PubMed:10400613, ECO:0000269|PubMed:15698960}.
uniprot
proteins
mass_dalton
47517
uniprot
proteins
mutagenesis
MUTAGEN 39; /note="C->S: No effect on protein stability. No effect on nucleoside-diphosphatase activity."; /evidence="ECO:0000269|PubMed:15698960
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:Q9WUZ9}.
uniprot
proteins
post_translational_modification
PTM: N-glycosylated; high-mannose type (By similarity). Glycosylation is not essential for enzymatic activity. {ECO:0000250|UniProtKB:Q9WUZ9, ECO:0000269|PubMed:11041857, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218}.
uniprot
proteins
protein_family
GDA1/CD39 NTPase family
uniprot
proteins
pubmed
10400613
uniprot
proteins
pubmed
10708485
uniprot
proteins
pubmed
11041857
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15698960
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
21074248
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9676430
uniprot
proteins
sequence_length
428
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9WUZ9}. Secreted {ECO:0000269|PubMed:10400613, ECO:0000269|PubMed:15698960}.
uniprot
proteins