Mlxip
entrez
208104
canonical
uniprot
Q2VPU4
canonical
ensembl
ENSMUSG00000038342
resolver
ensp
ENSMUSP00000064943
resolver
ensp
ENSMUSP00000107223
resolver
enst
ENSMUST00000068237
resolver
enst
ENSMUST00000111596
resolver
genesymbol
Mlxip
resolver
genesymbol_syn
Mir
resolver
uniprot
B2RQ56
resolver
uniprot
F6QQF3
resolver
uniprot
G5E8D8
resolver
uniprot
Q6NXJ4
resolver
uniprot
Q6P9J8
resolver
uniprot
Q8C8C6
resolver
uniprot
Q8VI53
resolver
uniprot_entry
B2RQ56_MOUSE
resolver
uniprot_entry
F6QQF3_MOUSE
resolver
uniprot_entry
G5E8D8_MOUSE
resolver
uniprot_entry
MLXIP_MOUSE
resolver
uniprot_sec
Q6NXJ4
resolver
uniprot_sec
Q6P9J8
resolver
uniprot_sec
Q8C8C6
resolver
uniprot_sec
Q8VI53
resolver
amino_acid_sequence
MAADVFMCSPRRPRSRGRSVLLKPQVPEDDDDSDTDEPSPPPPSGVATSARAHASAAPLPPRAGPGREEPPRRQQIIHSGHFMVSSPHREHPPKKGYDFDTVNKQTCQTYSFGKTSSCHLSIDASLTKLFECMTLAYSGKLVSPKWKNFKGLKLQWRDKIRLNNAIWRAWYMQYLEKRRNPVCHFVTPLDGSVDVDEHRRPEAITTEGKYWKSRIEIVIREYHKWRTYFKKRLQQHKDEDLSSLAQDDDMLYWHKHGDGWKTPVPMEEDSLLDTDMLMSEFSDTLFSTLSSHQPVAWPNPREIAHLGNADMIQPGLIPLQPNLDFMDTFEPFQDLFSSSRSIFGSMLPPPSSLPAADPSSPPSQGNILPNTALPPASLPNSLITSSAAPSLDPTEGQGCERTSQTVDPFIQPADFGPSEPPLSVPQPFLPVFTMTLLSPGPAPAPVPTALPLVPSPAPTLNPPTPPAFLQPQKFAGVSKSTPVITHTASATLTHDASATTFSQNQGLVITAHHPTPSSSPCALALSPVPQPPAVGPPQPHLTFIHPKPVSLTGVRHKQPPKIVPAPKPEPVSLVLKNACIAPAAFSGQPQKVIMTSAPLKREGILASTVSPSNVVIASAAITRASGVTEFLSHSTSSQPSPVSRLFSPSTVQDSLVKGEQVSLHGGSPQVPATGSSRDCPNSGQASPCPSEQSPSPQSPQNNCSGKSTDPKNVAALKNRQKHISAEQKRRFNIRMGFNTLNSLISNNSKQTSHAITLQKTMEYITKLQQERMQMQEEARRLREEIEELNTTIISCQQLLPATGVPVNCRQLDHMRDMFDEYVKSRTLQNWKFWIFSMIIKPLFESFKGMVSTSSLEEFHRTALSWLDQHCSLPVLRPMVLSTLRQLSTTTSILTDPSQLPEQASEAVTRMGKRSGES
uniprot
proteins
function
FUNCTION: Binds DNA as a heterodimer with MLX/TCFL4 and activates transcription. Binds to the canonical E box sequence 5'-CACGTG-3'. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation (By similarity) (PubMed:11073985, PubMed:16644671). Regulates transcription in response to changes in cellular carbohydrate abundance such as occurs during fasting to feeding metabolic transition. Refeeding stimulates MLXIPL/ChREBP transcription factor, leading to increased BCKDK to PPM1K expression ratio, phosphorylation and activation of ACLY that ultimately results in the generation of malonyl-CoA and oxaloacetate immediate substrates of de novo lipogenesis and gluconeogenesis, respectively (PubMed:29779826). {ECO:0000250|UniProtKB:Q9HAP2, ECO:0000269|PubMed:11073985, ECO:0000269|PubMed:16644671, ECO:0000269|PubMed:29779826}.
uniprot
proteins
mass_dalton
100804
uniprot
proteins
pubmed
11073985
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16644671
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29779826
uniprot
proteins
sequence_length
917
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11073985}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:11073985}. Mitochondrion outer membrane {ECO:0000269|PubMed:11073985}. Note=Predominantly cytoplasmic but shuttles between cytoplasm and nucleus when associated with MLX. Also associates with the outer mitochondrial membrane and may shuttle between the outer mitochondrial membrane and the nucleus. {ECO:0000250|UniProtKB:Q9HAP2, ECO:0000269|PubMed:11073985}.
uniprot
proteins