Emc9
entrez
85308
canonical
uniprot
Q9DB76
canonical
ensembl
ENSMUSG00000022217
resolver
ensp
ENSMUSP00000022828
resolver
ensp
ENSMUSP00000133463
resolver
ensp
ENSMUSP00000302528
resolver
enst
ENSMUST00000022828
resolver
genesymbol
Emc9
resolver
genesymbol_syn
Cgi112
resolver
genesymbol_syn
Fam158a
resolver
uniprot
Q793L1
resolver
uniprot_entry
EMC9_MOUSE
resolver
uniprot_entry
Q793L1_MOUSE
resolver
amino_acid_sequence
MGEVEISARAYGKMCLHASRYPHAAVNGLLLAPATGSGECLCLTDCVPLFHSHLALSVMLEVALNQVDVWGAQAGLVVAGYYHANAVLDDQSPGPLALKIAGRIAEFFPRAVLIMLDNKKLVTRPRVPPVIVLENQGLQWVPKDKNLVMWRDWEESRQMVGALLEGRAHQHLVDFDCHLDDIRQDWTNQRLNTQITQWSGSTDGNA
uniprot
proteins
function
FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. {ECO:0000250|UniProtKB:Q9Y3B6}.
uniprot
proteins
mass_dalton
22787
uniprot
proteins
protein_family
EMC8/EMC9 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
206
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Y3B6}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9Y3B6}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Y3B6}.
uniprot
proteins