Ascl2
entrez
24209
canonical
uniprot
P19360
canonical
ensembl
ENSRNOG00000020434
resolver
ensembl
ENSRNOG00060031630
resolver
ensp
ENSRNOP00000027688
resolver
ensp
ENSRNOP00060045321
resolver
enst
ENSRNOT00000027688
resolver
enst
ENSRNOT00060054811
resolver
genesymbol
Ascl2
resolver
genesymbol_syn
Ash2
resolver
genesymbol_syn
Mash-2
resolver
genesymbol_syn
Mash2
resolver
uniprot_entry
ASCL2_RAT
resolver
amino_acid_sequence
MESHFNWYGVPRLQKASDACPRESCSSALPEAREGANVHFPPHPVPREHFSCGAPKPVAGAPALNASLMDGGALPRLVPTSSGVAGACTARRRPPSPELLRCSRRRRSGATEASSSSAAVARRNERERNRVKLVNLGFQALRQHVPHGGANKKLSKVETLRSAVEYIRALQRLLAEHDAVRAALSGGLLTPATRPSDVCTQPSASPASASLSCTSTSPDRLGCSEPASPRSAYSSEDSSCEGETYPMGQMFDFSNWLGGY
uniprot
proteins
function
FUNCTION: Transcription factor (PubMed:1314394). Binds to E-box motifs 5'-CANNTG-3' in the regulatory elements of target genes, probably as a heterodimer with another basic helix-loop-helix (bHLH) protein such as the transcription factor TCF3. May bind both open and closed chromatin, acting as a pioneer transcription factor to allow other factors to bind and activate lineage-specific genes. Required during post-implantation development for the generation of some differentiated trophoblast cell types. Transcriptional activity of ASCL2 may be antagonised in a subset of trophoblast cells by bHLH transcription factor HAND1, perhaps by competing for dimerization with other bHLH proteins. Involved in differentiation and function of follicular T-helper (Tfh) cells, thereby playing a role in germinal center responses; probably modulates expression of genes involved in Tfh cell function, such as BCL6. May also act as a suppressor of Th1-, Th2- and Th17-cell differentiation. Induces the formation of stem cells in intestinal crypts in vitro, synergistically activating transcription of target genes, such as SOX9, together with TCF4/beta-catenin. May form a bistable transcriptional switch, controlling expression of its own gene together with Wnt/R-spondin signaling, and thereby maintaining stem cell characteristics (By similarity). Modulates expression of target genes, including perhaps down-regulating EGR1/Krox24 and chemokine CXCL10/Mob-1 and up-regulating CXCR4 and CDKN1C/p57kip2, in Schwann cells (PubMed:12196582). May play a role in reducing proliferation of Schwann cells, perhaps acting via modulation of expression of CDKN1C (PubMed:12196582). May be dispensable for blastocyst formation and later embryonic function (By similarity). May be involved in the determination of neuronal precursors (PubMed:2392153). {ECO:0000250|UniProtKB:O35885, ECO:0000269|PubMed:12196582, ECO:0000269|PubMed:1314394, ECO:0000269|PubMed:2392153}.
uniprot
proteins
mass_dalton
27695
uniprot
proteins
pubmed
12196582
uniprot
proteins
pubmed
1314394
uniprot
proteins
pubmed
2392153
uniprot
proteins
sequence_length
260
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:12196582}. Cytoplasm {ECO:0000269|PubMed:12196582}.
uniprot
proteins