SAMTOR
entrez
154743
canonical
uniprot
Q1RMZ1
canonical
ensembl
ENSG00000164603
resolver
ensp
ENSP00000297145
resolver
enst
ENST00000297145
resolver
genesymbol
SAMTOR
resolver
genesymbol_syn
BMT2
resolver
genesymbol_syn
C7orf60
resolver
hgnc
HGNC:26475
resolver
uniprot
Q8N3D0
resolver
uniprot
Q96MV7
resolver
uniprot_entry
SAMTR_HUMAN
resolver
uniprot_sec
Q8N3D0
resolver
uniprot_sec
Q96MV7
resolver
amino_acid_sequence
MEPGAGGRNTARAQRAGSPNTPPPREQERKLEQEKLSGVVKSVHRRLRKKYREVGDFDKIWREHCEDEETLCEYAVAMKNLADNHWAKTCEGEGRIEWCCSVCREYFQNGGKRKALEKDEKRAVLATKTTPALNMHESSQLEGHLTNLSFTNPEFITELLQASGKIRLLDVGSCFNPFLKFEEFLTVGIDIVPAVESVYKCDFLNLQLQQPLQLAQDAIDAFLKQLKNPIDSLPGELFHVVVFSLLLSYFPSPYQRWICCKKAHELLVLNGLLLIITPDSSHQNRHAMMMKSWKIAIESLGFKRFKYSKFSHMHLMAFRKISLKTTSDLVSRNYPGMLYIPQDFNSIEDEEYSNPSCYVRSDIEDEQLAYGFTELPDAPYDSDSGESQASSIPFYELEDPILLLS
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes (PubMed:29123071, PubMed:35776786). Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling (PubMed:29123071, PubMed:35776786). Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling (PubMed:29123071, PubMed:35776786). Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase (Potential). {ECO:0000255|HAMAP-Rule:MF_03044, ECO:0000269|PubMed:29123071, ECO:0000269|PubMed:35776786}.
uniprot
proteins
mass_dalton
46324
uniprot
proteins
mutagenesis
MUTAGEN 95; /note="R->A: Abolished binding to S-adenosyl-L-methionine without affecting ability to associate with GATOR1 and KICSTOR complexes."; /evidence="ECO:0000269|PubMed:35776786"; MUTAGEN 175; /note="F->A: Strongly decreased ability to associate with GATOR1 and KICSTOR complexes."; /evidence="ECO:0000269|PubMed:35776786"; MUTAGEN 190; /note="D->A: Abolished binding to S-adenosyl-L-methionine without affecting ability to associate with GATOR1 and KICSTOR complexes."; /evidence="ECO:0000269|PubMed:35776786"; MUTAGEN 202; /note="D->A: Abolished binding to S-adenosyl-L-methionine without affecting ability to associate with GATOR1 and KICSTOR complexes."; /evidence="ECO:0000269|PubMed:35776786
uniprot
proteins
protein_family
BMT2/SAMTOR family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
29123071
uniprot
proteins
pubmed
29590090
uniprot
proteins
pubmed
35776786
uniprot
proteins
sequence_length
405
uniprot
proteins