Masp1
entrez
17174
canonical
uniprot
P98064
canonical
ensembl
ENSMUSG00000022887
resolver
ensp
ENSMUSP00000087327
resolver
ensp
ENSMUSP00000155343
resolver
ensp
ENSMUSP00000155665
resolver
enst
ENSMUST00000230040
resolver
genesymbol
Masp1
resolver
genesymbol_syn
Crarf
resolver
uniprot
A0A2R8VHR3
resolver
uniprot
A2RRH8
resolver
uniprot
A2RRH9
resolver
uniprot
Q8CD27
resolver
uniprot
Q8CIR8
resolver
uniprot
Q920S0
resolver
uniprot_entry
A0A2R8VHR3_MOUSE
resolver
uniprot_entry
MASP1_MOUSE
resolver
uniprot_sec
A2RRH8
resolver
uniprot_sec
A2RRH9
resolver
uniprot_sec
Q8CD27
resolver
uniprot_sec
Q8CIR8
resolver
uniprot_sec
Q920S0
resolver
amino_acid_sequence
MRFLSFWRLLLYHALCLALPEVSAHTVELNEMFGQIQSPGYPDSYPSDSEVTWNITVPEGFRIKLYFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGTFMSVTFRSDFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSGNLFTQRTGTITSPDYPNPYPKSSECSYTIDLEEGFMVSLQFEDIFDIEDHPEVPCPYDYIKIKAGSKVWGPFCGEKSPEPISTQTHSVQILFRSDNSGENRGWRLSYRAAGNECPKLQPPVYGKIEPSQAVYSFKDQVLVSCDTGYKVLKDNEVMDTFQIECLKDGAWSNKIPTCKIVDCGAPAGLKHGLVTFSTRNNLTTYKSEIRYSCQQPYYKMLHNTTGVYTCSAHGTWTNEVLKRSLPTCLPVCGVPKFSRKQISRIFNGRPAQKGTMPWIAMLSHLNGQPFCGGSLLGSNWVLTAAHCLHQSLDPEEPTLHSSYLLSPSDFKIIMGKHWRRRSDEDEQHLHVKRTTLHPLYNPSTFENDLGLVELSESPRLNDFVMPVCLPEQPSTEGTMVIVSGWGKQFLQRFPENLMEIEIPIVNSDTCQEAYTPLKKKVTKDMICAGEKEGGKDACAGDSGGPMVTKDAERDQWYLVGVVSWGEDCGKKDRYGVYSYIYPNKDWIQRITGVRN
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Precursor of a serum protease that activates the complement pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. {ECO:0000269|PubMed:18424734}.; FUNCTION: [Isoform MASP-1]: Serine protease that activates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:18424734, PubMed:31399515). The lectin complement system is activated following association of lectins, such as MBL2, FCN1, FCN2 or FCN3, to carbohydrates on the pathogen surface. Following autoproteolytic processing in response to lectin-binding to pathogen carbohydrates, catalyzes cleavage and activation of MASP2, the next component of the lectin complement pathway (By similarity). {ECO:0000250|UniProtKB:P48740, ECO:0000269|PubMed:18424734, ECO:0000269|PubMed:31399515}.; FUNCTION: [Isoform MASP-3]: Serine protease that activates the alternative pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:31399515, PubMed:36988282). The alternative complement pathway acts as an amplification loop that enhances other complement pathways (PubMed:31399515, PubMed:36988282). Isoform MASP-3 specifically catalyzes cleavage and activation of factor D (CFD), the protease that initiates the alternative complement pathway (PubMed:31399515, PubMed:36988282). {ECO:0000269|PubMed:31399515, ECO:0000269|PubMed:36988282}.
uniprot
proteins
mass_dalton
79968
uniprot
proteins
post_translational_modification
PTM: [Isoform MASP-1]: Autoproteolytic processing of the proenzyme produces the active enzyme composed on the heavy and the light chain held together by a disulfide bond. {ECO:0000250|UniProtKB:P48740}.; PTM: [Isoform MASP-3]: In contrast to isoform MASP-1, not activated through autoproteolytic processing. {ECO:0000250|UniProtKB:P48740}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
12847554
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18424734
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31399515
uniprot
proteins
pubmed
36988282
uniprot
proteins
pubmed
8133044
uniprot
proteins
pubmed
8439319
uniprot
proteins
sequence_length
704
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8133044}.; SUBCELLULAR LOCATION: [Isoform MASP-1]: Secreted {ECO:0000250|UniProtKB:P48740}. Cell surface {ECO:0000250|UniProtKB:P48740}. Note=Recruited to the surface of pathogens by the mannose-binding proteins, such as MBL2. {ECO:0000250|UniProtKB:P48740}.; SUBCELLULAR LOCATION: [Isoform MASP-3]: Secreted {ECO:0000250|UniProtKB:P48740}.
uniprot
proteins