Dph2
entrez
298452
canonical
uniprot
Q568Y2
canonical
ensembl
ENSRNOG00055012840
resolver
ensembl
ENSRNOG00060013758
resolver
ensembl
ENSRNOG00065017112
resolver
ensp
ENSRNOP00055017796
resolver
ensp
ENSRNOP00060018640
resolver
ensp
ENSRNOP00065022609
resolver
enst
ENSRNOT00055021954
resolver
enst
ENSRNOT00060023484
resolver
enst
ENSRNOT00065028555
resolver
genesymbol
Dph2
resolver
uniprot_entry
DPH2_RAT
resolver
amino_acid_sequence
MESTFSSPAEAALQREAGVPGQFTPPEDLDRVYELERVTRFICDLGCQRVALQFPDQLLGDAGAVAARLEEVTGSKMFILGDTAYGSCCVDVLGAEQAGAQALVHFGPACLSPPASLLPITFVLGRRPVALELCAKAFEAQNPDPTALVVLLSEPACAHALEPLATLLRPKYQDLLISSPALPLPVGSLSSQPESLERFGRRFPLNPGRSLEEYGAFYVGASQASSDPNLDPDLSRLLLGWTPGRPFFSCCPDTGQTQDQGAKAGRLRARRLYLVERARDARVVGLLVGTLGVAQHLEALAHLRKLTEAAGKRSYVLALGKPTPAKLANFPEMDVFVLLACPLGALTLQPSGGFFRPILTPCELEAACNPAWPPPGLAPHLTHYAELLPGSPFHVPLPPPESELWDTPDVSLISGELRPPPPWKSSDDTKCSALTPRPQLELAESSPAASFLSSRSWQGLEPRLGQTPVKEAVQGRRGIAIAYEDEGSS
uniprot
proteins
function
FUNCTION: Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (By similarity). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (By similarity). {ECO:0000250|UniProtKB:P32461}.
uniprot
proteins
mass_dalton
52325
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; peptidyl-diphthamide biosynthesis. {ECO:0000305}.
uniprot
proteins
protein_family
DPH1/DPH2 family
uniprot
proteins
protein_family
DPH2 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
489
uniprot
proteins