GATAD2A
entrez
54815
canonical
uniprot
Q86YP4
canonical
ensembl
ENSG00000167491
resolver
ensp
ENSP00000353463
resolver
ensp
ENSP00000508398
resolver
ensp
ENSP00000538363
resolver
ensp
ENSP00000538364
resolver
ensp
ENSP00000538365
resolver
ensp
ENSP00000538367
resolver
ensp
ENSP00000538368
resolver
ensp
ENSP00000538369
resolver
ensp
ENSP00000538370
resolver
ensp
ENSP00000538371
resolver
ensp
ENSP00000538372
resolver
ensp
ENSP00000538374
resolver
ensp
ENSP00000538375
resolver
ensp
ENSP00000538377
resolver
ensp
ENSP00000538379
resolver
ensp
ENSP00000538381
resolver
ensp
ENSP00000585115
resolver
ensp
ENSP00000585119
resolver
ensp
ENSP00000585121
resolver
ensp
ENSP00000585127
resolver
ensp
ENSP00000626425
resolver
genesymbol
GATAD2A
resolver
hgnc
HGNC:29989
resolver
uniprot
B5MC40
resolver
uniprot
Q7L3J2
resolver
uniprot
Q96F28
resolver
uniprot
Q9NPU2
resolver
uniprot
Q9NXS1
resolver
uniprot_entry
P66A_HUMAN
resolver
uniprot_sec
B5MC40
resolver
uniprot_sec
Q7L3J2
resolver
uniprot_sec
Q96F28
resolver
uniprot_sec
Q9NPU2
resolver
uniprot_sec
Q9NXS1
resolver
amino_acid_sequence
MTEEACRTRSQKRALERDPTEDDVESKKIKMERGLLASDLNTDGDMRVTPEPGAGPTQGLLRATEATAMAMGRGEGLVGDGPVDMRTSHSDMKSERRPPSPDVIVLSDNEQPSSPRVNGLTTVALKETSTEALMKSSPEERERMIKQLKEELRLEEAKLVLLKKLRQSQIQKEATAQKPTGSVGSTVTTPPPLVRGTQNIPAGKPSLQTSSARMPGSVIPPPLVRGGQQASSKLGPQASSQVVMPPLVRGAQQIHSIRQHSSTGPPPLLLAPRASVPSVQIQGQRIIQQGLIRVANVPNTSLLVNIPQPTPASLKGTTATSAQANSTPTSVASVVTSAESPASRQAAAKLALRKQLEKTLLEIPPPKPPAPEMNFLPSAANNEFIYLVGLEEVVQNLLETQGRMSAATVLSREPYMCAQCKTDFTCRWREEKSGAIMCENCMTTNQKKALKVEHTSRLKAAFVKALQQEQEIEQRLLQQGTAPAQAKAEPTAAPHPVLKQVIKPRRKLAFRSGEARDWSNGAVLQASSQLSRGSATTPRGVLHTFSPSPKLQNSASATALVSRTGRHSERTVSAGKGSATSNWKKTPLSTGGTLAFVSPSLAVHKSSSAVDRQREYLLDMIPPRSIPQSATWK
uniprot
proteins
function
FUNCTION: Transcriptional repressor (PubMed:12183469, PubMed:16415179). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Enhances MBD2-mediated repression (PubMed:12183469, PubMed:16415179). Efficient repression requires the presence of GATAD2B (PubMed:16415179). {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666}.
uniprot
proteins
mass_dalton
68063
uniprot
proteins
mutagenesis
MUTAGEN 149; /note="K->R: Disruption of MBD2-binding, loss of enhancement of MBD2-mediated repression and loss of speckled nuclear localization."; /evidence="ECO:0000269|PubMed:16415179
uniprot
proteins
pubmed
12183469
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16415179
uniprot
proteins
pubmed
16428440
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21490301
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
26030138
uniprot
proteins
pubmed
27732854
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28977666
uniprot
proteins
pubmed
33283408
uniprot
proteins
pubmed
35916866
uniprot
proteins
sequence_length
633
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:12183469, ECO:0000269|PubMed:16415179}. Nucleus {ECO:0000269|PubMed:27732854, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:33283408}. Chromosome {ECO:0000269|PubMed:27732854}. Note=Speckled nuclear localization requires both CR1 and CR2 regions (PubMed:16415179). Localizes to sites of DNA damage in a manner partially dependent on ZMYND8 (PubMed:27732854). {ECO:0000269|PubMed:16415179, ECO:0000269|PubMed:27732854}.
uniprot
proteins