DDX4
entrez
54514
canonical
uniprot
Q9NQI0
canonical
ensembl
ENSG00000152670
resolver
ensp
ENSP00000334167
resolver
ensp
ENSP00000423123
resolver
ensp
ENSP00000424838
resolver
ensp
ENSP00000425359
resolver
genesymbol
DDX4
resolver
genesymbol_syn
VASA
resolver
hgnc
HGNC:18700
resolver
uniprot
A8K8Q2
resolver
uniprot
B3KSF4
resolver
uniprot
D6RDK4
resolver
uniprot
E9PCD8
resolver
uniprot
Q5M7Z3
resolver
uniprot
Q86VX0
resolver
uniprot
Q9NT92
resolver
uniprot
Q9NYB1
resolver
uniprot_entry
DDX4_HUMAN
resolver
uniprot_sec
A8K8Q2
resolver
uniprot_sec
B3KSF4
resolver
uniprot_sec
D6RDK4
resolver
uniprot_sec
E9PCD8
resolver
uniprot_sec
Q5M7Z3
resolver
uniprot_sec
Q86VX0
resolver
uniprot_sec
Q9NT92
resolver
uniprot_sec
Q9NYB1
resolver
amino_acid_sequence
MGDEDWEAEINPHMSSYVPIFEKDRYSGENGDNFNRTPASSSEMDDGPSRRDHFMKSGFASGRNFGNRDAGECNKRDNTSTMGGFGVGKSFGNRGFSNSRFEDGDSSGFWRESSNDCEDNPTRNRGFSKRGGYRDGNNSEASGPYRRGGRGSFRGCRGGFGLGSPNNDLDPDECMQRTGGLFGSRRPVLSGTGNGDTSQSRSGSGSERGGYKGLNEEVITGSGKNSWKSEAEGGESSDTQGPKVTYIPPPPPEDEDSIFAHYQTGINFDKYDTILVEVSGHDAPPAILTFEEANLCQTLNNNIAKAGYTKLTPVQKYSIPIILAGRDLMACAQTGSGKTAAFLLPILAHMMHDGITASRFKELQEPECIIVAPTRELVNQIYLEARKFSFGTCVRAVVIYGGTQLGHSIRQIVQGCNILCATPGRLMDIIGKEKIGLKQIKYLVLDEADRMLDMGFGPEMKKLISCPGMPSKEQRQTLMFSATFPEEIQRLAAEFLKSNYLFVAVGQVGGACRDVQQTVLQVGQFSKREKLVEILRNIGDERTMVFVETKKKADFIATFLCQEKISTTSIHGDREQREREQALGDFRFGKCPVLVATSVAARGLDIENVQHVINFDLPSTIDEYVHRIGRTGRCGNTGRAISFFDLESDNHLAQPLVKVLTDAQQDVPAWLEEIAFSTYIPGFSGSTRGNVFASVDTRKGKSTLNTAGFSSSQAPNPVDDESWD
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: ATP-dependent RNA helicase required during spermatogenesis (PubMed:10920202, PubMed:21034600). Required to repress transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (By similarity). Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle (By similarity). Required for PIWIL2 slicing-triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs into piRNAs (By similarity). {ECO:0000250|UniProtKB:Q61496, ECO:0000269|PubMed:10920202, ECO:0000269|PubMed:21034600}.
uniprot
proteins
mass_dalton
79308
uniprot
proteins
protein_family
DDX4/VASA subfamily
uniprot
proteins
protein_family
DEAD box helicase family
uniprot
proteins
pubmed
10920202
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21034600
uniprot
proteins
pubmed
21421998
uniprot
proteins
pubmed
27622290
uniprot
proteins
sequence_length
724
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q61496}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q61496}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250|UniProtKB:Q61496}.
uniprot
proteins