RSPO4
entrez
343637
canonical
uniprot
Q2I0M5
canonical
ensembl
ENSG00000101282
resolver
ensp
ENSP00000217260
resolver
ensp
ENSP00000383475
resolver
ensp
ENSP00000729105
resolver
genesymbol
RSPO4
resolver
genesymbol_syn
C20orf182
resolver
hgnc
HGNC:16175
resolver
uniprot
A2A2I6
resolver
uniprot
Q9UGB2
resolver
uniprot_entry
RSPO4_HUMAN
resolver
uniprot_sec
A2A2I6
resolver
uniprot_sec
Q9UGB2
resolver
amino_acid_sequence
MRAPLCLLLLVAHAVDMLALNRRKKQVGTGLGGNCTGCIICSEENGCSTCQQRLFLFIRREGIRQYGKCLHDCPPGYFGIRGQEVNRCKKCGATCESCFSQDFCIRCKRQFYLYKGKCLPTCPPGTLAHQNTRECQGECELGPWGGWSPCTHNGKTCGSAWGLESRVREAGRAGHEEAATCQVLSESRKCPIQRPCPGERSPGQKKGRKDRRPRKDRKLDRRLDVRPRQPGLQP
uniprot
proteins
disease_involvement
DISEASE: Nail disorder, non-syndromic congenital, 4 (NDNC4) [MIM:206800]: A nail disorder characterized by congenital anonychia or its milder phenotypic variant hyponychia. Anonychia/hyponychia is the absence or severe hypoplasia of all fingernails and toenails without significant bone anomalies. {ECO:0000269|PubMed:17041604}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors (PubMed:29769720). Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway (PubMed:21727895, PubMed:21909076). {ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:29769720}.
uniprot
proteins
mass_dalton
26171
uniprot
proteins
post_translational_modification
PTM: Tyr-112 may be phosphorylated; however as this position is probably extracellular, the vivo relevance is not proven.
uniprot
proteins
protein_family
R-spondin family
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
16357527
uniprot
proteins
pubmed
17041604
uniprot
proteins
pubmed
21727895
uniprot
proteins
pubmed
21909076
uniprot
proteins
pubmed
29769720
uniprot
proteins
sequence_length
234
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
uniprot
proteins