Slc4a8
entrez
315311
canonical
uniprot
Q6RVG2
canonical
ensembl
ENSRNOG00000028879
resolver
ensembl
ENSRNOG00055027151
resolver
ensembl
ENSRNOG00060015352
resolver
ensp
ENSRNOP00000043825
resolver
ensp
ENSRNOP00000107489
resolver
genesymbol
Slc4a8
resolver
genesymbol_syn
Ndcbe1
resolver
uniprot
F1LUB7
resolver
uniprot
Q6RVG1
resolver
uniprot
Q6RVG3
resolver
uniprot_entry
S4A8_RAT
resolver
uniprot_sec
F1LUB7
resolver
uniprot_sec
Q6RVG1
resolver
uniprot_sec
Q6RVG3
resolver
amino_acid_sequence
MPAGSNEPDGVLSYQRPDEEAVVDQGGTSTILNIHYEKEELEGHRTLYVGVRMPLGRQSHRHHRTHGQKHRRRGGRGKGASQGEEGLEASAHDTPSQRVQFILGTEEDEEHVPHELFTELDEICMKEGEEAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCLINGSVLLDMRASSIEEISDLILDQQELLRDLSDSVRVKVREALLKKHHHQNEKKRNNLIPIVRSFAEVGKKQSDPHSMDRDGQTVSPQSAPATNLEVKNGVNCEHSPVDLSKADLHFMKKIPAGAEASNVLVGEVDTLDRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGPVGKGQQYHEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRKMPGVPNGNICHVEPEPHGGHSGPELERTGRLFGGLVLDVKRKAPWYWSDYRDALSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQPLTILGSTGPVLVFEKILFKFCKDYALSYLSLRACIGLWTAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCALPENPNNHTLQYWKEHSIPTADVNWANLTVSECQEMHGEFIGSACGHHGPYTPDVLFWSCILFFATFIVSSTLKTFKTSRYFPTRVRSTVSDFAVFLTIFTMVILDFLIGVPSPKLQVPSVFKPTRDDRGWFISPIGPNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLVVAIMLGVCSLMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFVLMGCSVFMTAVLKFIPMPVLYGVFLYMGVSSLQGIQFFDRLKLFGMPAKHQPDFIYLRHVPLRKVHLFTLVQLTCLVLLWVIKASPAAIVFPMMVLALVFVRKVMDLCFSKRELSWLDDLMPESKKKKLDDAKKKEEEEEAEKMLDIGGDKFPLESRKLLSSPGKNNSFRCDPSEINISDEMPKTTVWKALSINSGNTKEKSPFN
uniprot
proteins
function
FUNCTION: Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1 (PubMed:34584093, PubMed:8189393). Plays a major role in pH regulation in neurons (PubMed:8189393). Mediates sodium reabsorption in the renal cortical collecting ducts (By similarity). {ECO:0000250|UniProtKB:Q8JZR6, ECO:0000269|PubMed:34584093, ECO:0000269|PubMed:8189393}.
uniprot
proteins
mass_dalton
122489
uniprot
proteins
mutagenesis
MUTAGEN 492; /note="P->C: 60% of wild-type transporter activity. No effect on cell membrane localization."; /evidence="ECO:0000269|PubMed:34584093"; MUTAGEN 496; /note="F->C: 40% of wild-type transporter activity. No effect on cell membrane localization."; /evidence="ECO:0000269|PubMed:34584093"; MUTAGEN 536; /note="G->C: 20% of wild-type transporter activity. No effect on cell membrane localization."; /evidence="ECO:0000269|PubMed:34584093"; MUTAGEN 538; /note="T->C: 60% of wild-type transporter activity. No effect on cell membrane localization."; /evidence="ECO:0000269|PubMed:34584093"; MUTAGEN 539; /note="G->C: 40% of wild-type transporter activity. No effect on cell membrane localization."; /evidence="ECO:0000269|PubMed:34584093"; MUTAGEN 540; /note="P->C: 40% of wild-type transporter activity. No effect on cell membrane localization."; /evidence="ECO:0000269|PubMed:34584093"; MUTAGEN 608; /note="E->C: 40% of wild-type transporter activity. No effect on cell membrane localization."; /evidence="ECO:0000269|PubMed:34584093"; MUTAGEN 612; /note="K->C: 40% of wild-type transporter activity. No effect on cell membrane localization."; /evidence="ECO:0000269|PubMed:34584093"; MUTAGEN 800; /note="D->C: 40% of wild-type transporter activity. No effect on cell membrane localization."; /evidence="ECO:0000269|PubMed:34584093"; MUTAGEN 804; /note="T->C: 20% of wild-type transporter activity. No effect on cell membrane localization."; /evidence="ECO:0000269|PubMed:34584093"; MUTAGEN 845; /note="A->C: 40% of wild-type transporter activity. No effect on cell membrane localization."; /evidence="ECO:0000269|PubMed:34584093"; MUTAGEN 846; /note="A->C: 40% of wild-type transporter activity. No effect on cell membrane localization."; /evidence="ECO:0000269|PubMed:34584093"; MUTAGEN 847; /note="T->C: 60% of wild-type transporter activity. No effect on cell membrane localization."; /evidence="ECO:0000269|PubMed:34584093"; MUTAGEN 848; /note="V->C: 40% of wild-type transporter activity. No effect on cell membrane localization."; /evidence="ECO:0000269|PubMed:34584093"; MUTAGEN 852; /note="T->C: 40% of wild-type transporter activity. No effect on cell membrane localization."; /evidence="ECO:0000269|PubMed:34584093"; MUTAGEN 879; /note="R->C: 60% of wild-type transporter activity. No effect on cell membrane localization."; /evidence="ECO:0000269|PubMed:34584093"; MUTAGEN 914; /note="M->C: 40% of wild-type transporter activity. No effect on cell membrane localization."; /evidence="ECO:0000269|PubMed:34584093"; MUTAGEN 970; /note="K->C: 60% of wild-type transporter activity. No effect on cell membrane localization."; /evidence="ECO:0000269|PubMed:34584093
uniprot
proteins
protein_family
Anion exchanger (TC 2.A.31) family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
17715183
uniprot
proteins
pubmed
18359573
uniprot
proteins
pubmed
21195699
uniprot
proteins
pubmed
22102085
uniprot
proteins
pubmed
34584093
uniprot
proteins
pubmed
8189393
uniprot
proteins
sequence_length
1092
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18359573, ECO:0000269|PubMed:34584093}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q2Y0W8}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:18359573, ECO:0000269|PubMed:21195699}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:22102085}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 479..499; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 508..528; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 566..586; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 596..616; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 688..708; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 732..752; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 779..799; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 825..845; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 882..902; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 905..925; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 963..983; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins