HYOU1
entrez
10525
canonical
uniprot
Q9Y4L1
canonical
ensembl
ENSG00000149428
resolver
ensembl
ENSG00000280682
resolver
ensp
ENSP00000431874
resolver
ensp
ENSP00000462951
resolver
ensp
ENSP00000480150
resolver
ensp
ENSP00000480248
resolver
ensp
ENSP00000498353
resolver
ensp
ENSP00000498859
resolver
ensp
ENSP00000511598
resolver
ensp
ENSP00000511599
resolver
ensp
ENSP00000511601
resolver
ensp
ENSP00000530961
resolver
ensp
ENSP00000530966
resolver
ensp
ENSP00000530967
resolver
ensp
ENSP00000584488
resolver
ensp
ENSP00000634823
resolver
enst
ENST00000652049
resolver
enst
ENST00000652093
resolver
enst
ENST00000694932
resolver
enst
ENST00000694933
resolver
enst
ENST00000694935
resolver
enst
ENST00000860902
resolver
enst
ENST00000860907
resolver
enst
ENST00000860908
resolver
enst
ENST00000914429
resolver
enst
ENST00000964764
resolver
genesymbol
HYOU1
resolver
genesymbol_syn
GRP170
resolver
genesymbol_syn
HSPH4
resolver
genesymbol_syn
ORP150
resolver
hgnc
HGNC:16931
resolver
uniprot
A0A384P5T6
resolver
uniprot
A0A494C039
resolver
uniprot
A0A8Q3SHG4
resolver
uniprot
A8C1Z0
resolver
uniprot
B3KXH0
resolver
uniprot
B7Z602
resolver
uniprot
B7Z766
resolver
uniprot
B7Z909
resolver
uniprot
Q2I204
resolver
uniprot
Q53H25
resolver
uniprot
Q6IN67
resolver
uniprot_entry
A0A384P5T6_HUMAN
resolver
uniprot_entry
A0A494C039_HUMAN
resolver
uniprot_entry
A0A8Q3SHG4_HUMAN
resolver
uniprot_entry
B3KXH0_HUMAN
resolver
uniprot_entry
B7Z602_HUMAN
resolver
uniprot_entry
B7Z766_HUMAN
resolver
uniprot_entry
HYOU1_HUMAN
resolver
uniprot_entry
Q6IN67_HUMAN
resolver
uniprot_sec
A8C1Z0
resolver
uniprot_sec
B7Z909
resolver
uniprot_sec
Q2I204
resolver
uniprot_sec
Q53H25
resolver
amino_acid_sequence
MADKVRRQRPRRRVCWALVAVLLADLLALSDTLAVMSVDLGSESMKVAIVKPGVPMEIVLNKESRRKTPVIVTLKENERFFGDSAASMAIKNPKATLRYFQHLLGKQADNPHVALYQARFPEHELTFDPQRQTVHFQISSQLQFSPEEVLGMVLNYSRSLAEDFAEQPIKDAVITVPVFFNQAERRAVLQAARMAGLKVLQLINDNTATALSYGVFRRKDINTTAQNIMFYDMGSGSTVCTIVTYQMVKTKEAGMQPQLQIRGVGFDRTLGGLEMELRLRERLAGLFNEQRKGQRAKDVRENPRAMAKLLREANRLKTVLSANADHMAQIEGLMDDVDFKAKVTRVEFEELCADLFERVPGPVQQALQSAEMSLDEIEQVILVGGATRVPRVQEVLLKAVGKEELGKNINADEAAAMGAVYQAAALSKAFKVKPFVVRDAVVYPILVEFTREVEEEPGIHSLKHNKRVLFSRMGPYPQRKVITFNRYSHDFNFHINYGDLGFLGPEDLRVFGSQNLTTVKLKGVGDSFKKYPDYESKGIKAHFNLDESGVLSLDRVESVFETLVEDSAEEESTLTKLGNTISSLFGGGTTPDAKENGTDTVQEEEESPAEGSKDEPGEQVELKEEAEAPVEDGSQPPPPEPKGDATPEGEKATEKENGDKSEAQKPSEKAEAGPEGVAPAPEGEKKQKPARKRRMVEEIGVELVVLDLPDLPEDKLAQSVQKLQDLTLRDLEKQEREKAANSLEAFIFETQDKLYQPEYQEVSTEEQREEISGKLSAASTWLEDEGVGATTVMLKEKLAELRKLCQGLFFRVEERKKWPERLSALDNLLNHSSMFLKGARLIPEMDQIFTEVEMTTLEKVINETWAWKNATLAEQAKLPATEKPVLLSKDIEAKMMALDREVQYLLNKAKFTKPRPRPKDKNGTRAEPPLNASASDQGEKVIPPAGQTEDAEPISEPEKVETGSEPGDTEPLELGGPGAEPEQKEQSTGQKRPLKNDEL
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency 59 and hypoglycemia (IMD59) [MIM:233600]: An autosomal recessive primary immunologic disorder characterized by combined immunodeficiency, granulocytopenia, B-cell and dendritic cell deficiency, recurrent septic infections of the respiratory tract, skin and mucous membranes, and disturbed glucose metabolism. {ECO:0000269|PubMed:27913302}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. Promotes HSPA5/BiP-mediated ATP nucleotide exchange and thereby activates the unfolded protein response (UPR) pathway in the presence of endoplasmic reticulum stress (By similarity). May play a role as a molecular chaperone and participate in protein folding. {ECO:0000250|UniProtKB:Q9JKR6, ECO:0000269|PubMed:10037731}.
uniprot
proteins
mass_dalton
111335
uniprot
proteins
protein_family
Heat shock protein 70 family
uniprot
proteins
pubmed
10037731
uniprot
proteins
pubmed
10965054
uniprot
proteins
pubmed
12475965
uniprot
proteins
pubmed
12754519
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16263699
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17131193
uniprot
proteins
pubmed
18663603
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27913302
uniprot
proteins
pubmed
9020069
uniprot
proteins
sequence_length
999
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen.
uniprot
proteins