Hsd3b5
entrez
24470
canonical
uniprot
P27364
canonical
ensembl
ENSRNOG00000019417
resolver
ensembl
ENSRNOG00055032797
resolver
ensembl
ENSRNOG00060013782
resolver
ensembl
ENSRNOG00065030863
resolver
ensp
ENSRNOP00000072555
resolver
ensp
ENSRNOP00055046819
resolver
ensp
ENSRNOP00060018693
resolver
ensp
ENSRNOP00065043678
resolver
enst
ENSRNOT00000079754
resolver
enst
ENSRNOT00055056713
resolver
enst
ENSRNOT00060023537
resolver
enst
ENSRNOT00065053181
resolver
genesymbol
Hsd3b5
resolver
genesymbol_syn
Hsd3b
resolver
genesymbol_syn
LOC100911116
resolver
uniprot
A0A0G2JSR3
resolver
uniprot
Q569C6
resolver
uniprot_entry
3BHS5_RAT
resolver
uniprot_entry
A0A0G2JSR3_RAT
resolver
uniprot_sec
Q569C6
resolver
amino_acid_sequence
MPGWSCLVTGAGGFLGQRIVQMLVQEKELQEVRVLYRTFSPKHKEELSKLQTKAKVTVLRGDIVDAQFLRRACQGMSVIIHTAAALDIAGFLPRQTILDVNVKGTQLLLDACVEASVPAFIYSSSTGVAGPNSYKETILNDREEEHRESTWSNPYPYSKRMAEKAVLAANGSILKNGGTFHTCALRLPFIYGEESQIISTMVNRALKNNSIIKRHATFSIANPVYVGNAAWAHILAARGLRDPEKSQSIQGQFYYISDDTPHQSYDDLNYTLSKEWGFCLDSSWSLPLPLLYWLAFLLETVSFLLRPFYNYRPPFNRFMVTILNSVFTISYKKAQRDLGYEPLVSWEEAKQKTSEWIGTLVEQHRETLDTKSQ
uniprot
proteins
ec_number
1.1.1.210
uniprot
proteins
ec_number
1.1.1.270
uniprot
proteins
function
FUNCTION: Responsible for the reduction of the oxo group on the C-3 of 5alpha-androstane steroids. Catalyzes the conversion of dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone. Does not function as an isomerase. {ECO:0000269|PubMed:1537836}.
uniprot
proteins
mass_dalton
42206
uniprot
proteins
pathway_participation
PATHWAY: Steroid metabolism. {ECO:0000269|PubMed:1537836}.
uniprot
proteins
protein_family
3-beta-HSD family
uniprot
proteins
pubmed
1537836
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2249649
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 288..308; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins