Npy
entrez
24604
canonical
uniprot
P07808
canonical
ensembl
ENSRNOG00000046449
resolver
ensp
ENSRNOP00000066713
resolver
enst
ENSRNOT00000074351
resolver
genesymbol
Npy
resolver
uniprot
F2W8A6
resolver
uniprot
F2W8A7
resolver
uniprot
M0RAZ3
resolver
uniprot_entry
F2W8A6_RAT
resolver
uniprot_entry
F2W8A7_RAT
resolver
uniprot_entry
NPY_RAT
resolver
uniprot_sec
M0RAZ3
resolver
amino_acid_sequence
MMLGNKRMGLCGLTLALSLLVCLGILAEGYPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRYGKRSSPETLISDLLMRESTENAPRTRLEDPSMW
uniprot
proteins
function
FUNCTION: [Neuropeptide Y]: Ligand for neuropeptide Y receptor type 1 (NPY1R) and neuropeptide Y receptor type 2 (NPY2R). Receptor binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production. Receptor activation by NPY also leads to an increase of intracellular Ca(2+) levels. Is involved in the regulation of eating behavior, acting as a stimulator of food intake (PubMed:25109664, PubMed:2560178, PubMed:6549409). Involved in the regulation of colonic antisecretory tone, and colonic contractility (By similarity). {ECO:0000250|UniProtKB:P01303, ECO:0000250|UniProtKB:P57774, ECO:0000269|PubMed:25109664, ECO:0000269|PubMed:2560178, ECO:0000269|PubMed:6549409}.
uniprot
proteins
mass_dalton
11033
uniprot
proteins
post_translational_modification
PTM: The neuropeptide Y form is cleaved at Pro-31 by the prolyl endopeptidase FAP (seprase) activity (in vitro). {ECO:0000250|UniProtKB:P01303}.
uniprot
proteins
protein_family
NPY family
uniprot
proteins
pubmed
25109664
uniprot
proteins
pubmed
2560178
uniprot
proteins
pubmed
2834371
uniprot
proteins
pubmed
29166604
uniprot
proteins
pubmed
30021165
uniprot
proteins
pubmed
3031663
uniprot
proteins
pubmed
3031687
uniprot
proteins
pubmed
3413293
uniprot
proteins
pubmed
6549409
uniprot
proteins
sequence_length
98
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P57774}. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle {ECO:0000269|PubMed:29166604, ECO:0000269|PubMed:30021165}.
uniprot
proteins