Pck2
entrez
74551
canonical
uniprot
Q8BH04
canonical
ensembl
ENSMUSG00000040618
resolver
ensp
ENSMUSP00000038555
resolver
ensp
ENSMUSP00000153733
resolver
enst
ENSMUST00000048781
resolver
enst
ENSMUST00000226519
resolver
genesymbol
Pck2
resolver
uniprot
A0A0R4J0G0
resolver
uniprot
Q8BMM9
resolver
uniprot
Q91Z10
resolver
uniprot_entry
A0A0R4J0G0_MOUSE
resolver
uniprot_entry
PCKGM_MOUSE
resolver
uniprot_sec
Q8BMM9
resolver
uniprot_sec
Q91Z10
resolver
amino_acid_sequence
MAAMYLPGLRLSRHGLRPWCWSPCRSIQTLHVLSGDMSQLPAGVRDFVARSAHLCQPEGIHICDGTEAENTAILALLEEQGLIRKLPKYKNCWLARTDPKDVARVESKTVIVTPSQRDTVPLLAGGARGQLGNWMSPDEFQRAVDERFPGCMQGRIMYVLPFSMGPVGSPLSRIGVQLTDSAYVVASMRIMTRLGTPVLQALGDGDFIKCLHSVGQPLTGHGDPVGQWPCNPEKTLIGHVPDQREIVSFGSGYGGNSLLGKKCFALRIASRLARDEGWLAEHMLILGITNPAGKKRYVAAAFPSACGKTNLAMMRPALPGWKVECVGDDIAWMRFDSEGQLRAINPENGFFGVAPGTSAATNPNAMATIQSNTLFTNVAETSDGGVYWEGIDQPLPPGVTITSWLGKPWKPGDKEPCAHPNSRFCVPARQCPIMDPAWEAPEGVPIDAIIFGGRRPKGVPLVYEAFNWRHGVFVGSAMRSESTAAAEHKGKTIMHDPFAMRPFFGYNFGRYLEHWLSMEGQKGARLPRIFHVNWFRRDEAGRFLWPGFGENARVLDWICRRLEGEDSAQETPIGLVPKEGALDLSGLSAVDTSQLFSIPKDFWEQEVRDIRGYLTEQVNQDLPKEVLAELEALEGRVQKM
uniprot
proteins
ec_number
2.7.11.-
uniprot
proteins
ec_number
4.1.1.32
uniprot
proteins
function
FUNCTION: Mitochondrial phosphoenolpyruvate carboxykinase that catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity). Can play an active role in glyceroneogenesis and gluconeogenesis (PubMed:33147485). In lipogenic cells such as adipocytes, it generates PEP via the mitochondrial pyruvate-to-PEP bypass, driving the PEP flux required for cytosolic glycerol 3-phosphate and triglyceride synthesis (PubMed:41850288). Also acts as a serine/threonine-protein kinase: phosphorylates and activates ACSL4, thereby promoting ferroptosis (By similarity). {ECO:0000250|UniProtKB:Q16822, ECO:0000269|PubMed:33147485, ECO:0000269|PubMed:41850288}.
uniprot
proteins
mass_dalton
70528
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate biosynthesis; gluconeogenesis. {ECO:0000305|PubMed:33147485}.; PATHWAY: Glycerolipid metabolism; triacylglycerol biosynthesis. {ECO:0000269|PubMed:41850288}.
uniprot
proteins
protein_family
Phosphoenolpyruvate carboxykinase [GTP] family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
33147485
uniprot
proteins
pubmed
36845668
uniprot
proteins
pubmed
41850288
uniprot
proteins
sequence_length
640
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q16822}.
uniprot
proteins