P01834
uniprot
P01834
canonical
amino_acid_sequence
RTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC
uniprot
proteins
disease_involvement
DISEASE: Immunoglobulin kappa light chain deficiency (IGKCD) [MIM:614102]: A disease characterized by the complete absence of immunoglobulin kappa chains. {ECO:0000269|PubMed:3931219}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). {ECO:0000303|PubMed:17576170, ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
uniprot
proteins
mass_dalton
11765
uniprot
proteins
pubmed
11549845
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17576170
uniprot
proteins
pubmed
20176268
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22158414
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25946035
uniprot
proteins
pubmed
3931219
uniprot
proteins
pubmed
4893682
uniprot
proteins
pubmed
4923144
uniprot
proteins
pubmed
5027703
uniprot
proteins
pubmed
5447531
uniprot
proteins
pubmed
5489770
uniprot
proteins
pubmed
5586923
uniprot
proteins
pubmed
6775818
uniprot
proteins
pubmed
9588180
uniprot
proteins
sequence_length
107
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}. Cell membrane {ECO:0000303|PubMed:20176268, ECO:0000303|PubMed:22158414}.
uniprot
proteins