Pacsin2
entrez
124461
canonical
uniprot
Q9QY17
canonical
ensembl
ENSRNOG00000009756
resolver
ensp
ENSRNOP00000072822
resolver
ensp
ENSRNOP00000087304
resolver
enst
ENSRNOT00000111896
resolver
genesymbol
Pacsin2
resolver
uniprot
A0A8I6A2Y6
resolver
uniprot
Q6IRI3
resolver
uniprot
Q9QY18
resolver
uniprot
Q9QY19
resolver
uniprot
Q9QY20
resolver
uniprot_entry
A0A8I6A2Y6_RAT
resolver
uniprot_entry
PACN2_RAT
resolver
uniprot_entry
Q6IRI3_RAT
resolver
uniprot_sec
Q9QY18
resolver
uniprot_sec
Q9QY19
resolver
uniprot_sec
Q9QY20
resolver
amino_acid_sequence
MSVTYDDSVGVEVSSDSFWEVGNYKRTVKRIDDGHRLCGDLMNCLHERARIEKAYAQQLTEWARRWRQLVEKGPQYGTVEKAWMAVMSEAERVSELHLEVKASLMNEDFEKIKNWQKEAFHKQMMGGFKETKEAEDGFRKAQKPWAKKLKEVDAAKKAHHTACKEEKLAVSREANSKADPSLNPEQLKKLQDKIEKCKQDVLKTKDKYEKALKELDQTTPQYMENMEQVFEQCQQFEEKRLRFFREVLLEVQKHLDLSNVASYKGIYRELEQSIKAADAVEDLRWFRANHGPGMAMNWPQFEDEEWSADLNRTLSRREKKKAADGVTLTGINQTGDQSGQNKPSSNLSVPSNPAQSTQLQSSYNPFEDEDDTGSSVSEKEDIKAKNVSSYEKTQNYPADWSDDESNNPFSSTDANGDSNPFDEDTTSGTEVRVRALYDYEGQEHDELSFKAGDELTKIEDEDEQGWCKGRLDSGQVGLYPANYVEAIQ
uniprot
proteins
function
FUNCTION: Regulates the morphogenesis and endocytosis of caveolae (PubMed:22718246). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. Facilitates endothelial front-rear polarity during migration by recruiting EHD4 and MICALL1 to asymmetric adherens junctions between leader and follower cells (By similarity). {ECO:0000250|UniProtKB:Q9WVE8, ECO:0000269|PubMed:10704453, ECO:0000269|PubMed:22718246}.
uniprot
proteins
mass_dalton
55978
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC). Phosphorylation by PKC probably decreases the membrane binding and tubulation capacities of PACSIN2, thereby modulating the lifetime of caveolae (By similarity). {ECO:0000250|UniProtKB:Q9WVE8}.
uniprot
proteins
protein_family
PACSIN family
uniprot
proteins
pubmed
10704453
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
22718246
uniprot
proteins
sequence_length
488
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10704453}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9WVE8}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:10704453}; Peripheral membrane protein {ECO:0000269|PubMed:10704453}; Cytoplasmic side {ECO:0000269|PubMed:10704453}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q9WVE8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9WVE8}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9WVE8}. Early endosome {ECO:0000250|UniProtKB:Q9WVE8}. Recycling endosome membrane {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:22718246}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9WVE8}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9WVE8}. Cell projection {ECO:0000250|UniProtKB:Q9UNF0}. Membrane, caveola {ECO:0000269|PubMed:22718246}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9WVE8}. Note=Detected at the neck of flask-shaped caveolae. Localization to tubular recycling endosomes probably requires interaction with MICALL1 and EHD1. {ECO:0000250|UniProtKB:Q9WVE8}.
uniprot
proteins