Tnfaip8l3
entrez
244882
canonical
uniprot
Q3TBL6
canonical
ensembl
ENSMUSG00000074345
resolver
ensp
ENSMUSP00000096356
resolver
enst
ENSMUST00000098760
resolver
genesymbol
Tnfaip8l3
resolver
uniprot_entry
TP8L3_MOUSE
resolver
amino_acid_sequence
MDSDSGEQSEGEPGTAAGPHVFSSKNLALQAQKKILSKIASKTVANMLIDDTSSEIFDELYKVTEIHTHNKKEAHKIMKDAIKVAIKIGILYRNKQFSQEEVIIVEKLRKKLNQTAMTMVSFYEVEYTFDTNVLSKLLHECKDLVHELVQRHLTPRTHGRINHVFNHFADVEFLSTLYGPHGNCRPNLKRICEGINKLLDDKIL
uniprot
proteins
function
FUNCTION: Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling. {ECO:0000269|PubMed:25242044}.
uniprot
proteins
mass_dalton
23243
uniprot
proteins
mutagenesis
MUTAGEN 33; /note="K->Q: Reduces binding to phosphoinositide; when associated with Gln-34; Gln-38 and Gln-42."; /evidence="ECO:0000269|PubMed:25242044"; MUTAGEN 34; /note="K->Q: Reduces binding to phosphoinositide; when associated with Gln-33; Gln-38 and Gln-42."; /evidence="ECO:0000269|PubMed:25242044"; MUTAGEN 38; /note="K->Q: Reduces binding to phosphoinositide; when associated with Gln-33; Gln-34 and Gln-42."; /evidence="ECO:0000269|PubMed:25242044"; MUTAGEN 42; /note="K->Q: Reduces binding to phosphoinositide; when associated with Gln-33; Gln-34 and Gln-38."; /evidence="ECO:0000269|PubMed:25242044"; MUTAGEN 60; /note="L->W: Reduces binding to phosphoinositide."; /evidence="ECO:0000269|PubMed:25242044"; MUTAGEN 93; /note="R->Q: Reduces binding to phosphoinositide; when associated with Gln-109."; /evidence="ECO:0000269|PubMed:25242044"; MUTAGEN 109; /note="R->Q: Reduces binding to phosphoinositide; when associated with Gln-93."; /evidence="ECO:0000269|PubMed:25242044
uniprot
proteins
protein_family
TNFAIP8 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25242044
uniprot
proteins
pubmed
25479791
uniprot
proteins
sequence_length
204
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25479791}. Cell membrane {ECO:0000269|PubMed:25242044}. Note=On PDGF activation, translocates from cytoplasm to plasma membrane. {ECO:0000269|PubMed:25242044}.
uniprot
proteins