Sipa1l1
entrez
246212
canonical
uniprot
O35412
canonical
ensembl
ENSRNOG00000007646
resolver
ensp
ENSRNOP00000075549
resolver
ensp
ENSRNOP00000109852
resolver
enst
ENSRNOT00000088917
resolver
enst
ENSRNOT00000168984
resolver
genesymbol
Sipa1l1
resolver
genesymbol_syn
Spa1
resolver
uniprot
A0A0G2KAW2
resolver
uniprot
A0ABK0LGB5
resolver
uniprot_entry
A0A0G2KAW2_RAT
resolver
uniprot_entry
A0ABK0LGB5_RAT
resolver
uniprot_entry
SI1L1_RAT
resolver
amino_acid_sequence
MTSLKRSQTERPVTADRASVVSTDGTPKVHTDDFYMRRFRSQNGSLGSSVMAAVGPPRSEGPHHITSTPGVPKMGVRARIADWPPRKENVKESSRSSQEIETSSCLESLSSKGSPVSQGSSVSLNSNDSAMLKSIQNTLKNKTGPAESMDSRFLMPEAYPSSPRKALRRIRQRSNSDITISELDVDSFDECISPTYKSGPSLHREYGSTSSIDKQGTSGESFFGLLKGYKDDRADRGPTPTKLSDFLITGGGKGSGFSLDVIDGPISQRENLRLFKEREKPLKRRSKSETGDSSIFRKLRNAKGEELGKSSDLEDNRSEDSVRPWTCPKCFAHYDVQSILFDLNEAIMNRHNVIKRRNTTTGASAAAVASLVSGPLSHSTSFSSPMGSTEDFNSKGSLGMDQGDDKSNELVMSCPYFRNEIGGEGERKISLSKSNSGSFSGCESTSFESALSSHCTNAGVAVLEVPKESLMLHLDRVRRYTVEHVDLGAYYYRKCFYQKEHWNYFGADENLGPVAVSIRREKPEDMKENGSPYNYRIIFRTSELMTLRGSVLEDAIPSTAKHSTARGLPLKEVLEHVIPELNVQCLRLAFNTPKVTEQLMKLDEQGLNYQQKVGIMYCKAGQSTEEEMYNTPKVTEQFMKLDEQGLNYQQKVGIMYCKAGQSTEEEMYNNESAGPAFEEFLQLLGERVRLKGFEKYRAQLDTKTDSTGTHSLYTTYKDYEIMFHVSTMLPYTPNNKQQLLRKRHIGNDIVTIVFQEPGAQPFSPKNIRSHFQHVFVIVRAHNPCTESVCYSVAVTRSRDVPSFGPPIPKGVTFPKSNVFRDFLLAKVINAENAAHKSEKFRAMATRTRQEYLKDLAEKNVTNTPIDPSGKFPFISLASKKKEKSKPYPGAELSSMGAIVWAVRAKDYNKAMEFDCLLGISNEFIVLIEQETKSVVFNCSCRDVIGWTSSDSSLKIFYERGECISVESFMSSEDIKEIVKRLQFVSKGCESVEMTLRRNGLGQLGFHVNYEGIVADVEPYGYAWQAGLKQGSRLVEICKVAVATLSHEQMIDLLRTSVTVKVVIIPPHDDCTPRRSCSETYRMPVMEYKMNEGVSYEYKFPFRSNNKWQRNAGKGAHSPQVPLQLQSPMISRVNAGKGDGKMPLPERAANIPRSISSDGRPLERRLSPGSDIYVTVSSMALARSQCRNSPSNLSSSSETGSGGGTYRQKSMPEGFGVSRRSPASIDRQNTQSDIGGSGKSTPSWQRSEDSLADQMEPTCHLPAVSKVLPAFRESPSGRLMRQDPVVHLSPNKQGHSDSHYSSHSSSNTLSSNASSAHSDEKWYDGDRTESDLNSYNYLQGTSADSGIDTASYGLSHGSTASLGASTSSPRSGPGKEKVAPLWHSSSEVLSLADRTLETEGHGMDRKTESSLSLDIHSKSQGGSSPLTRENSTFSINDATSHTSTMSSRHSASPVVFSSARSSPKEELHPTTSSQLAPSFSSSSSSSSGPRTFYPRQGATSKYLIGWKKPEGTINSVGFMDTRKRHQSDGNEIAHTRLRASTRDLRASPKPTSKSTIEEDLKKLIDLESPTPESQKNFKFHGLSSPQSPFPSTPTSRRALHRTLSDESIYSSQREHFFTSRASLLDQALPNDVFFSSTYPSLPKSLPLRRPSYTLGMKSLHGEFFASDSSLTDIQETRRQPIPDPGLMPLPDTASDLDWSNLVDAAKAYEVQRASFFAASDENHRPLSAASNSDQLEEQALVQMKSYSSSKDSSPTLASKVDQLEGMLKMLREDLKKEKEDKAHLQAEVEHLREDNLRLQEESQNASDKLKKFTEWVFNTIDMS
uniprot
proteins
function
FUNCTION: Stimulates the GTPase activity of RAP2A. Promotes reorganization of the actin cytoskeleton and recruits DLG4 to F-actin. Contributes to the regulation of dendritic spine morphogenesis. {ECO:0000269|PubMed:11502259}.
uniprot
proteins
mass_dalton
201925
uniprot
proteins
mutagenesis
MUTAGEN 743; /note="R->A: Decreases stimulation of the GTPase activity of RAP2A."; /evidence="ECO:0000269|PubMed:11502259"; MUTAGEN 846..847; /note="RT->AS: Abolishes stimulation of the GTPase activity of RAP2A."; /evidence="ECO:0000269|PubMed:11502259"; MUTAGEN 1344; /note="S->A: Abolishes ubiquitination and degradation by the proteasome; when associated with A-1348."; /evidence="ECO:0000269|PubMed:18723513"; MUTAGEN 1348; /note="T->A: Abolishes ubiquitination and degradation by the proteasome; when associated with A-1344."; /evidence="ECO:0000269|PubMed:18723513"; MUTAGEN 1367; /note="S->A: Abolishes phosphorylation by CDK5 and subsequent phosphorylation by PLK2, leading to prevent ubiquitination and degradation by the proteasome."; /evidence="ECO:0000269|PubMed:18498738
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated and degraded by the SCF(BTRC) following phosphorylation by PLK2.; PTM: Phosphorylated at Ser-1367 by CDK5, creating a docking site for the POLO box domains of PLK2. Subsequently, PLK2 binds and phosphorylates SIPA1L1, leading to ubiquitination and degradation by the proteasome. {ECO:0000269|PubMed:18498738}.
uniprot
proteins
pubmed
11502259
uniprot
proteins
pubmed
16522626
uniprot
proteins
pubmed
18094260
uniprot
proteins
pubmed
18498738
uniprot
proteins
pubmed
18723513
uniprot
proteins
pubmed
19900557
uniprot
proteins
pubmed
21382555
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
1822
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Postsynaptic density. Synapse, synaptosome. Note=Associated with the actin cytoskeleton. Detected at synapses and dendritic spines of cultured hippocampal neurons.
uniprot
proteins