Micu2
entrez
171433
canonical
uniprot
Q99P63
canonical
ensembl
ENSRNOG00000011168
resolver
ensp
ENSRNOP00000015233
resolver
ensp
ENSRNOP00000074918
resolver
genesymbol
Micu2
resolver
genesymbol_syn
Efha1
resolver
genesymbol_syn
Smhs2
resolver
uniprot_entry
MICU2_RAT
resolver
amino_acid_sequence
MAAAAGRSAWLAAWGGRLRRGLAAGRRAVPTRGPLAAAVAGVALAGAGAAWHHGRVKAAAREGSRTVSAQKNYLGPIEKLSLRKQRFMQFSSLEHDGEYYMTPRDFLFSVMFEQVERKTLVKKLAKKDIEDVLSGIQTARCGSTFFRDLGDKGVISYTEYLFLLTILTKPHSGFHVAFKMLDVDGNEMIERKEFVRLQKIISKQDGFKTVKTNETEYQDPTVKEPGVNTTLQVRFFGKRGEKKLHYKEFRRFVENLQTEVQEMEFLQFSKGLNFMRKEDFAEWLLFFTNTENKDIYWRNVREKLSVGESISLDEFKSFCHFTTHLEDFAIAMQTFSLAHRPVRLAEFKRAVKVATGQELSDNLLDTVFKIFDLDGDECLSHGEFLGVLKNRMHRGLWVSQQQSVQEYWKCVKKESIKGVKEAWRQQAGKGPF
uniprot
proteins
function
FUNCTION: Calcium sensor of the mitochondrial calcium uniporter (MCU) channel, which senses calcium level via its EF-hand domains. MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium. At low calcium levels, MICU1 occludes the pore of the MCU channel, preventing mitochondrial calcium uptake. At higher calcium levels, calcium-binding to MICU1 and MICU2 induces a conformational change that weakens MCU-MICU1 interactions and moves the MICU1-MICU2 heterodimer away from the pore, allowing calcium permeation through the MCU channel. {ECO:0000250|UniProtKB:Q8IYU8}.
uniprot
proteins
mass_dalton
49442
uniprot
proteins
protein_family
MICU1 family
uniprot
proteins
protein_family
MICU2 subfamily
uniprot
proteins
pubmed
11596118
uniprot
proteins
sequence_length
432
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000250|UniProtKB:Q8IYU8}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q8IYU8}. Note=Recruited to the mitochondrial inner membrane via its association with the uniplex complex. {ECO:0000250|UniProtKB:Q8IYU8}.
uniprot
proteins