Slc4a10
entrez
94229
canonical
uniprot
Q5DTL9
canonical
ensembl
ENSMUSG00000026904
resolver
ensp
ENSMUSP00000061411
resolver
ensp
ENSMUSP00000099796
resolver
ensp
ENSMUSP00000108099
resolver
ensp
ENSMUSP00000160987
resolver
ensp
ENSMUSP00000160989
resolver
ensp
ENSMUSP00000160993
resolver
ensp
ENSMUSP00000160998
resolver
ensp
ENSMUSP00000161001
resolver
genesymbol
Slc4a10
resolver
genesymbol_syn
Kiaa4136
resolver
genesymbol_syn
Ncbe
resolver
uniprot
B1AWV9
resolver
uniprot
E9NX85
resolver
uniprot
F1DFN1
resolver
uniprot
G3F8Y7
resolver
uniprot
G3F8Y8
resolver
uniprot
G3F8Y9
resolver
uniprot
G3F8Z0
resolver
uniprot
I6VS12
resolver
uniprot
J7K287
resolver
uniprot
Q8C943
resolver
uniprot
Q8CFS3
resolver
uniprot
Q9EST0
resolver
uniprot
R4H243
resolver
uniprot_entry
B1AWV9_MOUSE
resolver
uniprot_entry
Q8C943_MOUSE
resolver
uniprot_entry
R4H243_MOUSE
resolver
uniprot_entry
S4A10_MOUSE
resolver
uniprot_sec
E9NX85
resolver
uniprot_sec
F1DFN1
resolver
uniprot_sec
G3F8Y7
resolver
uniprot_sec
G3F8Y8
resolver
uniprot_sec
G3F8Y9
resolver
uniprot_sec
G3F8Z0
resolver
uniprot_sec
I6VS12
resolver
uniprot_sec
J7K287
resolver
uniprot_sec
Q8CFS3
resolver
uniprot_sec
Q9EST0
resolver
activity_regulation
ACTIVITY REGULATION: [Isoform 2]: Zinc-binding negatively regulates its activity. {ECO:0000269|PubMed:28935959}.
uniprot
proteins
amino_acid_sequence
MEIKDQGAQMEPLLPTRNDEEAVVDRGGTRSILKTHFEKEDLEGHRTLFIGVHVPLGGRKSHRRHRHRGHKHRKRDRERDSGLEDGRESPSFDTPSQRVQFILGTEDDDEEHLPHDLFTELDEICWREGEDAEWRETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVLLDMHANTIEEIADMVLDQQVSSGQLNEDVRHRVHEALMKQHHHQNQKKLANRIPIVRSFADIGKKQSEPNSMDKNAGQVVSPQSAPACAENKNDVSRENSTVDFSKGLGGQQKGHTSPCGMKQRLDKGPPHQQEREVDLHFMKKIPPGAEASNILVGELEFLDRTVVAFVRLSPAVLLQGLAEVPIPSRFLFILLGPLGKGQQYHEIGRSIATLMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRKIPAVPNGTAAHGEAEPHGGHSGPELQRTGRIFGGLILDIKRKAPFFWSDFRDAFSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFGGQPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSLVCYITRFTEEAFASLICIIFIYEALEKLFELSETYPINMHNDLELLTQYSCNCMEPHSPSNDTLKEWRESNLSASDIIWGNLTVSECRSLHGEYVGRACGHGHPYVPDVLFWSVILFFSTVTMSATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLIDYAIGIPSPKLQVPSVFKPTRDDRGWFVTPLGPNPWWTIIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFILMGSSVFMTSILKFIPMPVLYGVFLYMGASSLKGIQLFDRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTVIQMSCLGLLWIIKVSRAAIVFPMMVLALVFVRKLMDFLFTKRELSWLDDLMPESKKKKLEDAEKEEEQSMLAMEDEGTVQLPLEGHYRDDPSVINISDEMSKTAMWGNLLVTADNSKEKESRFPSKSSPS
uniprot
proteins
function
FUNCTION: Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH (PubMed:20566632). Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (PubMed:20566632). Has also been shown to act as a sodium/biocarbonate cotransporter which is not responsible for net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange (By similarity). Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid (PubMed:18165320). Acting on presynaptic intracellular pH, it promotes GABA release, reduces the excitability of CA1 pyramidal neurons, and modulates short-term synaptic plasticity (PubMed:26136660, PubMed:37459438). Required in retinal cells to maintain normal pH which is necessary for normal vision (PubMed:23056253). In the kidney, likely to mediate bicarbonate reclamation in the apical membrane of the proximal tubules (By similarity). {ECO:0000250|UniProtKB:Q6U841, ECO:0000250|UniProtKB:Q80ZA5, ECO:0000269|PubMed:18165320, ECO:0000269|PubMed:20566632, ECO:0000269|PubMed:23056253, ECO:0000269|PubMed:26136660, ECO:0000269|PubMed:37459438}.; FUNCTION: [Isoform 2]: Sodium/bicarbonate cotransporter which mediates cotransport of sodium and bicarbonate in association with an efflux of intracellular chloride. {ECO:0000269|PubMed:10993873}.
uniprot
proteins
mass_dalton
125817
uniprot
proteins
mutagenesis
MUTAGEN 585; /note="E->A: Reduced recovery of intracellular sodium-dependent pH."; /evidence="ECO:0000269|PubMed:20566632"; MUTAGEN 891; /note="E->A: Reduced recovery of intracellular sodium-dependent pH."; /evidence="ECO:0000269|PubMed:20566632"; MUTAGEN 893; /note="E->A: Reduced recovery of intracellular sodium-dependent pH."; /evidence="ECO:0000269|PubMed:20566632"; MUTAGEN 977; /note="H->L: Reduced recovery of intracellular sodium-dependent pH."; /evidence="ECO:0000269|PubMed:20566632
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:18061361}.
uniprot
proteins
protein_family
Anion exchanger (TC 2.A.31) family
uniprot
proteins
pubmed
10993873
uniprot
proteins
pubmed
14592810
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15567717
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17928512
uniprot
proteins
pubmed
18061361
uniprot
proteins
pubmed
18165320
uniprot
proteins
pubmed
20541593
uniprot
proteins
pubmed
20566632
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21439947
uniprot
proteins
pubmed
23056253
uniprot
proteins
pubmed
23409100
uniprot
proteins
pubmed
24905082
uniprot
proteins
pubmed
26136660
uniprot
proteins
pubmed
28935959
uniprot
proteins
pubmed
37459438
uniprot
proteins
sequence_length
1118
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:14592810, ECO:0000269|PubMed:18061361, ECO:0000269|PubMed:18165320, ECO:0000269|PubMed:20541593}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q80ZA5}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000269|PubMed:18165320, ECO:0000269|PubMed:23056253, ECO:0000269|PubMed:24905082}. Cell projection, axon {ECO:0000269|PubMed:23056253}. Perikaryon {ECO:0000269|PubMed:23056253}. Presynapse {ECO:0000269|PubMed:23056253, ECO:0000269|PubMed:26136660, ECO:0000269|PubMed:37459438}. Postsynapse {ECO:0000269|PubMed:23056253, ECO:0000269|PubMed:26136660}. Note=Detected in dendrites and axon terminals of retinal OFF bipolar cells and in axon terminals of ON bipolar cells (PubMed:23056253). In amacrine cells, located in the perikaryon (PubMed:23056253). Also detected in basal and apical dendrites of hippocampal pyramidal cells (PubMed:18165320). Localized to GABAergic inhibitory presynapses (PubMed:37459438). {ECO:0000269|PubMed:18165320, ECO:0000269|PubMed:23056253, ECO:0000269|PubMed:37459438}.
uniprot
proteins
transmembrane_region
TRANSMEM 510..530; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 539..559; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 563..583; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 597..617; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 627..647; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 721..741; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 763..783; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 810..830; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 856..876; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 913..933; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 936..956; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 999..1019; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins