AIRIM
entrez
54955
canonical
uniprot
Q9NX04
canonical
ensembl
ENSG00000116922
resolver
ensp
ENSP00000350704
resolver
ensp
ENSP00000476779
resolver
ensp
ENSP00000565488
resolver
ensp
ENSP00000565493
resolver
ensp
ENSP00000565495
resolver
ensp
ENSP00000565497
resolver
ensp
ENSP00000565498
resolver
ensp
ENSP00000565499
resolver
genesymbol
AIRIM
resolver
genesymbol_syn
C1orf109
resolver
hgnc
HGNC:26039
resolver
uniprot
B4DRQ5
resolver
uniprot
B7Z9X8
resolver
uniprot
D3DPT1
resolver
uniprot
Q8WVD1
resolver
uniprot_entry
AIRIM_HUMAN
resolver
uniprot_entry
B4DRQ5_HUMAN
resolver
uniprot_entry
B7Z9X8_HUMAN
resolver
uniprot_sec
D3DPT1
resolver
uniprot_sec
Q8WVD1
resolver
amino_acid_sequence
MTQDRPLLAVQEALKKCFPVVEEQQGLWQSALRDCQPLLSSLSNLAEQLQAAQNLRFEDVPALRAFPDLKERLRRKQLVAGDIVLDKLGERLAILLKVRDMVSSHVERVFQIYEQHADTVGIDAVLQPSAVSPSVADMLEWLQDIERHYRKSYLKRKYLLSSIQWGDLANIQALPKAWDRISKDEHQDLVQDILLNVSFFLEE
uniprot
proteins
function
FUNCTION: Part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity (PubMed:38554706). Involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (PubMed:35354024). {ECO:0000269|PubMed:35354024, ECO:0000269|PubMed:38554706}.
uniprot
proteins
mass_dalton
23373
uniprot
proteins
mutagenesis
MUTAGEN 63; /note="L->R: Loss of interaction with CINP. No effect on interaction with interaction with AFG2A and AFG2B."; /evidence="ECO:0000269|PubMed:38554706"; MUTAGEN 69; /note="L->R: Loss of interaction with CINP. No effect on interaction with interaction with AFG2A and AFG2B."; /evidence="ECO:0000269|PubMed:38554706"; MUTAGEN 73; /note="L->A: Loss of interaction with CINP. No effect on interaction with interaction with AFG2A and AFG2B."; /evidence="ECO:0000269|PubMed:38554706"; MUTAGEN 104; /note="S->A: Abolishes phosphorylation by CK2 kinase; when associated with A-134 and A-182."; /evidence="ECO:0000269|PubMed:22548824"; MUTAGEN 134; /note="S->A: Abolishes phosphorylation by CK2 kinase; when associated with A-104 and A-182."; /evidence="ECO:0000269|PubMed:22548824"; MUTAGEN 182; /note="S->A: Abolishes phosphorylation by CK2 kinase; when associated with A-104 and A-134."; /evidence="ECO:0000269|PubMed:22548824
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serines by CK2 kinase. {ECO:0000269|PubMed:22548824}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22548824
uniprot
proteins
pubmed
35354024
uniprot
proteins
pubmed
38554706
uniprot
proteins
sequence_length
203
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22548824}. Cytoplasm {ECO:0000269|PubMed:22548824}.
uniprot
proteins