Arhgdia
entrez
192662
canonical
uniprot
Q99PT1
canonical
ensembl
ENSMUSG00000025132
resolver
ensp
ENSMUSP00000063714
resolver
ensp
ENSMUSP00000101803
resolver
enst
ENSMUST00000067936
resolver
enst
ENSMUST00000106197
resolver
genesymbol
Arhgdia
resolver
genesymbol_syn
C87222
resolver
genesymbol_syn
Gdi1
resolver
uniprot
Q5M9P6
resolver
uniprot
Q8BPI0
resolver
uniprot
Q99KC4
resolver
uniprot_entry
GDIR1_MOUSE
resolver
uniprot_sec
Q5M9P6
resolver
uniprot_sec
Q8BPI0
resolver
uniprot_sec
Q99KC4
resolver
amino_acid_sequence
MAEQEPTAEQLAQIAAENEEDEHSVNYKPPAQKSIQEIQELDKDDESLRKYKEALLGRVAVSADPNVPNVIVTRLTLVCSTAPGPLELDLTGDLESFKKQSFVLKEGVEYRIKISFRVNREIVSGMKYIQHTYRKGVKIDKTDYMVGSYGPRAEEYEFLTPMEEAPKGMLARGSYNIKSRFTDDDKTDHLSWEWNLTIKKEWKD
uniprot
proteins
function
FUNCTION: Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1. {ECO:0000269|PubMed:19029984, ECO:0000269|PubMed:22628549, ECO:0000269|PubMed:23434736}.
uniprot
proteins
mass_dalton
23407
uniprot
proteins
mutagenesis
MUTAGEN 185; /note="Missing: Loss of interaction with CDC42, RHOA and RAC1."; /evidence="ECO:0000269|PubMed:23434736
uniprot
proteins
protein_family
Rho GDI family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19029984
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20696765
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22628549
uniprot
proteins
pubmed
23434736
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
204
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23434736}.
uniprot
proteins