Mlxipl
entrez
58805
canonical
uniprot
Q99MZ3
canonical
ensembl
ENSMUSG00000005373
resolver
ensp
ENSMUSP00000005507
resolver
genesymbol
Mlxipl
resolver
genesymbol_syn
Mio
resolver
genesymbol_syn
Wbscr14
resolver
uniprot
H9U1Q1
resolver
uniprot
Q99MY9
resolver
uniprot
Q99MZ0
resolver
uniprot
Q99MZ1
resolver
uniprot
Q99MZ2
resolver
uniprot
Q9JLM5
resolver
uniprot_entry
MLXPL_MOUSE
resolver
uniprot_sec
H9U1Q1
resolver
uniprot_sec
Q99MY9
resolver
uniprot_sec
Q99MZ0
resolver
uniprot_sec
Q99MZ1
resolver
uniprot_sec
Q99MZ2
resolver
uniprot_sec
Q9JLM5
resolver
amino_acid_sequence
MARALADLSVNLQVPRVVPSPDSDSDTDLEDPSPRRSAGGLHRSQVIHSGHFMVSSPHSDSLTRRRDQEGPVGLADFGPRSIDPTLTHLFECLSLAYSGKLVSPKWKNFKGLKLLCRDKIRLNNAIWRAWYIQYVQRRKSPVCGFVTPLQGSEADEHRKPEAVILEGNYWKRRIEVVMREYHKWRIYYKKRLRKSSREGDFLAPKQVEGGWPPPERWCEQLFSSVVPVLLGGSEEEPGGRQLLDLDCFLSDISDTLFTMTQPSPSSLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMEISDFFTNYRPPQTPTSSNYIESPSFGPMADSLFSSGILAPEMPSPASSSSSSGMTPHSGNTRLQARNSCSGPLDPNPFLSSEFLLPEDPKTKIPPAPGPTPLLPFPTPVKVHGLEPCTPSPFPTMAPPPSLLPEESLLSARFPFTSAPPAPGVSTLPAPTTFVPTPQPGPGPVPFSVDHLPHGYLEPVFGPHFTVPQGMQPRCKPSSPSPGGQKASPPTLASATASPTATATARDNNPCLTQLLRAAKPEQALEPPTMPGTLLRPPESPQDTVSEIPRARAFFPPIPAPTPPRPPPGPATLAPPRSLVVPKAERLSPPASSGSERRLSGDLNSIQPSGALSVHLSPPQTVLSRGRVDNNKMENRRITHISAEQKRRFNIKLGFDTLHGLVSTLSAQPSLKVSKATTLQKTAEYILMLQQERAAMQEEAQQLRDEIEELNAAINLCQQQLPATGVPITHQRFDQMRDMFDDYVRTRTLHNWKFWVFSILIRPLFESFNGMVSTASLHSLRQTSLAWLEQYCSLPALRPTVLNSLRQLSTSTSILTDPSLVPEQATRAVTEGTLGRPL
uniprot
proteins
function
FUNCTION: Glucose-responsive transcription activator that regulates fatty acid synthesis and glycolysis. Key determinant of systemic insulin sensitivity and glucose homeostasis. Important for the expression of fatty acid synthetic enzymes, including PC/Pcx, APOC4/Acl, ACACA/Acc1 and FASN/Fas (PubMed:22466288). Important for glucose-induced expression of L-type pyruvate kinase/PKLR (By similarity). Binds to the canonical and non-canonical E box DNA sequences 5'-CACGTG-3' and 5'-CACGCG-3' (PubMed:11230181). May also act as a transcriptional repressor (PubMed:11230181). {ECO:0000250|UniProtKB:Q8VIP2, ECO:0000269|PubMed:11230181, ECO:0000269|PubMed:22466288}.; FUNCTION: [Isoform 1]: Glucose-responsive transcription factor, which, in complex with MLX, induces the transcription of isoform 6 from an alternative promoter. {ECO:0000269|PubMed:22466288}.; FUNCTION: [Isoform 6]: Transcription factor, which exhibits higher transcriptional activity than isoform 1. {ECO:0000269|PubMed:22466288}.
uniprot
proteins
mass_dalton
94875
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-566 by AMPK inactivates the DNA-binding activity. {ECO:0000250|UniProtKB:Q8VIP2}.
uniprot
proteins
pubmed
10780788
uniprot
proteins
pubmed
11230181
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22466288
uniprot
proteins
sequence_length
864
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:22466288}. Note=Predominantly localized in the cytoplasm in low and high glucose conditions. {ECO:0000269|PubMed:22466288}.; SUBCELLULAR LOCATION: [Isoform 6]: Nucleus {ECO:0000269|PubMed:22466288}. Note=Localized in the nucleus in low and high glucose conditions. {ECO:0000269|PubMed:22466288}.
uniprot
proteins