Rragd
entrez
52187
canonical
uniprot
Q7TT45
canonical
ensembl
ENSMUSG00000028278
resolver
ensp
ENSMUSP00000029946
resolver
ensp
ENSMUSP00000095792
resolver
enst
ENSMUST00000029946
resolver
enst
ENSMUST00000098190
resolver
genesymbol
Rragd
resolver
genesymbol_syn
Ragd
resolver
uniprot
B1AWT2
resolver
uniprot
B1AWT3
resolver
uniprot
Q6GTT2
resolver
uniprot
Q9CYC2
resolver
uniprot_entry
B1AWT2_MOUSE
resolver
uniprot_entry
B1AWT3_MOUSE
resolver
uniprot_entry
RRAGD_MOUSE
resolver
uniprot_sec
Q6GTT2
resolver
uniprot_sec
Q9CYC2
resolver
activity_regulation
ACTIVITY REGULATION: The activation of RagD/RRAGD is mediated by a GTPase activating protein (GAP). In high-amino acid conditions, activated by GTPase activating protein FLCN that stimulates RRAGD GTPase activity to turn it into its active GDP-bound form (By similarity). In response to amino acid depletion, the GATOR1 complex inactivates RagC/RRAGC by securing the GTP-bound inactive form (By similarity). {ECO:0000250|UniProtKB:Q9HB90, ECO:0000250|UniProtKB:Q9NQL2}.
uniprot
proteins
amino_acid_sequence
MSQVLGKPQPQGEDGGEDQEEDELVGLAGYEDGPESSDAELDSGPEEGESRRNSWMPRSWCSEATRHECWEPGLWRSSHLLGIGGGWRMLRRQRQADFFLDFSDPFSTEVKPRILLMGLRRSGKSSIQKVVFHKMSPSETLFLESTNRICREDVSNSSFVNFQIWDFPGQIDFFDPTFDYEMIFRGTGALIFVIDSQDDYMEALARLHLTVTRAYKVNTDINFEVFIHKVDGLSDDHKIETQRDIHQRANDDLADAGLEKIHLSFYLTSIYDHSIFEAFSKVVQKLIPQLPTLENLLNIFISNSGIEKAFLFDVVSKIYIATDSTPVDMQTYELCCDMIDVVIDISCIYGLKEDGAGAPYDKDSTAIIKLNNTTVLYLKEVTKFLALVCFVREESFERKGLIDYNFHCFRKAIHEVFEVRMKMVKSRKAQSRLPKKTGATPNGTPRVLL
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RagA/RRAGA or RagB/RRAGB and cycles between an inactive GTP-bound and an active GDP-bound form: RagD/RRAGD is in its active form when GDP-bound RagD/RRAGD forms a complex with GTP-bound RagA/RRAGA (or RagB/RRAGB) and in an inactive form when GTP-bound RagD/RRAGD heterodimerizes with GDP-bound RagA/RRAGA (or RagB/RRAGB). In its active form, promotes the recruitment of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the MTOR signaling cascade by amino acids. Also plays a central role in the non-canonical mTORC1 complex, which acts independently of RHEB and specifically mediates phosphorylation of MiT/TFE factors TFEB and TFE3: GDP-bound RagD/RRAGD mediates recruitment of MiT/TFE factors TFEB and TFE3. {ECO:0000250|UniProtKB:Q9NQL2}.
uniprot
proteins
mass_dalton
51232
uniprot
proteins
protein_family
GTR/RAG GTP-binding protein family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
25259925
uniprot
proteins
pubmed
30595499
uniprot
proteins
pubmed
34607910
uniprot
proteins
sequence_length
449
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9NQL2}. Nucleus {ECO:0000250|UniProtKB:Q9NQL2}. Lysosome membrane {ECO:0000250|UniProtKB:Q9NQL2}. Note=Predominantly cytoplasmic. Recruited to the lysosome surface by the Ragulator complex. May shuttle between the cytoplasm and nucleus, depending on the bound nucleotide state of associated RRAGA. {ECO:0000250|UniProtKB:Q9NQL2}.
uniprot
proteins