Il22ra1
entrez
230828
canonical
uniprot
Q80XZ4
canonical
ensembl
ENSMUSG00000037157
resolver
ensp
ENSMUSP00000099605
resolver
enst
ENSMUST00000102546
resolver
genesymbol
Il22ra1
resolver
genesymbol_syn
9130219A07Rik
resolver
uniprot
B2RU51
resolver
uniprot
Q3TS18
resolver
uniprot
Q3URP9
resolver
uniprot_entry
I22R1_MOUSE
resolver
uniprot_entry
Q3TS18_MOUSE
resolver
uniprot_sec
B2RU51
resolver
uniprot_sec
Q3URP9
resolver
amino_acid_sequence
MKTLLTILTVGSLAAHTTVDTSGLLQHVKFQSSNFENILTWDGGPASTSDTVYSVEYKKYGERKWLAKAGCQRITQKFCNLTMETRNHTEFYYAKVTAVSAGGPPVTKMTDRFSSLQHTTIKPPDVTCIPKVRSIQMLVHPTLTPVLSEDGHQLTLEEIFHDLFYRLELHVNHTYQMHLEGKQREYEFLGLTPDTEFLGSITILTPILSKESAPYVCRVKTLPDRTWAYSFSGAVLFSMGFLVGLLCYLGYKYITKPPVPPNSLNVQRVLTFQPLRFIQEHVLIPVLDLSGPSSLPQPIQYSQVVVSGPREPPGAVWRQSLSDLTYVGQSDVSILQPTNVPAQQTLSPPSYAPKAVPEVQPPSYAPQVASDAKALFYSPQQGMKTRPATYDPQDILDSCPASYAVCVEDSGKDSTPGILSTPKYLKTKGQLQEDTLVRSCLPGDLSLQKVTSLGEGETQRPKSLPSPLGFCTDRGPDLHTLRSEEPETPRYLKGALSLLSSVQIEGHPVSLPLHVHSVSCSPSDEGPSPWGLLDSLVCPKDEGPAVETEAMCPSAAASELEQSTELDSLFKGLALTVQWES
uniprot
proteins
function
FUNCTION: Component of the receptor for IL20, IL22 and IL24. Component of IL22 receptor formed by IL22RA1 and IL10RB enabling IL22 signaling via JAK/STAT pathways. IL22 also induces activation of MAPK1/MAPK3 and Akt kinases pathways. Component of one of the receptor for IL20 and IL24 formed by IL22RA1 and IL20RB also signaling through STATs activation. Mediates IL24 antiangiogenic activity as well as IL24 inhibitory effect on endothelial cell tube formation and differentiation. {ECO:0000269|PubMed:12618864}.
uniprot
proteins
mass_dalton
63795
uniprot
proteins
mutagenesis
MUTAGEN 410; /note="S->A: Abolishes phosphorylation by GSK3B; reduces stability of the protein."; /evidence="ECO:0000269|PubMed:24742671"; MUTAGEN 414; /note="S->A: Abolishes phosphorylation by GSK3B; reduces stability of the protein."; /evidence="ECO:0000269|PubMed:24742671"; MUTAGEN 426; /note="K->R: No effect on protein degradation."; /evidence="ECO:0000269|PubMed:24742671"; MUTAGEN 428; /note="K->R: No effect on protein degradation."; /evidence="ECO:0000269|PubMed:24742671"; MUTAGEN 449; /note="K->R: Degradation-resistant mutant."; /evidence="ECO:0000269|PubMed:24742671"; MUTAGEN 540; /note="K->R: No effect on protein degradation."; /evidence="ECO:0000269|PubMed:24742671
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by GSK3-BETA and MAPK; phosphorylation by GSK3-BETA stabilizes IL22RA1 by preventing its proteasomal degradation. {ECO:0000269|PubMed:24742671}.
uniprot
proteins
protein_family
Type II cytokine receptor family
uniprot
proteins
pubmed
12618864
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
24742671
uniprot
proteins
sequence_length
581
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8N6P7}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 231..251; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins