NOP2
entrez
4839
canonical
uniprot
P46087
canonical
ensembl
ENSG00000111641
resolver
ensp
ENSP00000313272
resolver
ensp
ENSP00000371858
resolver
ensp
ENSP00000382392
resolver
ensp
ENSP00000439422
resolver
ensp
ENSP00000443150
resolver
genesymbol
NOP2
resolver
genesymbol_syn
NOL1
resolver
genesymbol_syn
NSUN1
resolver
hgnc
HGNC:7867
resolver
uniprot
A1A4Z3
resolver
uniprot
B3KPD6
resolver
uniprot
Q05BA7
resolver
uniprot
Q0P5S5
resolver
uniprot
Q3KQS4
resolver
uniprot
Q58F30
resolver
uniprot_entry
NOP2_HUMAN
resolver
uniprot_sec
A1A4Z3
resolver
uniprot_sec
B3KPD6
resolver
uniprot_sec
Q05BA7
resolver
uniprot_sec
Q0P5S5
resolver
uniprot_sec
Q3KQS4
resolver
uniprot_sec
Q58F30
resolver
amino_acid_sequence
MGRKLDPTKEKRGPGRKARKQKGAETELVRFLPAVSDENSKRLSSRARKRAAKRRLGSVEAPKTNKSPEAKPLPGKLPKGISAGAVQTAGKKGPQSLFNAPRGKKRPAPGSDEEEEEEDSEEDGMVNHGDLWGSEDDADTVDDYGADSNSEDEEEGEALLPIERAARKQKAREAAAGIQWSEEETEDEEEEKEVTPESGPPKVEEADGGLQINVDEEPFVLPPAGEMEQDAQAPDLQRVHKRIQDIVGILRDFGAQREEGRSRSEYLNRLKKDLAIYYSYGDFLLGKLMDLFPLSELVEFLEANEVPRPVTLRTNTLKTRRRDLAQALINRGVNLDPLGKWSKTGLVVYDSSVPIGATPEYLAGHYMLQGASSMLPVMALAPQEHERILDMCCAPGGKTSYMAQLMKNTGVILANDANAERLKSVVGNLHRLGVTNTIISHYDGRQFPKVVGGFDRVLLDAPCSGTGVISKDPAVKTNKDEKDILRCAHLQKELLLSAIDSVNATSKTGGYLVYCTCSITVEENEWVVDYALKKRNVRLVPTGLDFGQEGFTRFRERRFHPSLRSTRRFYPHTHNMDGFFIAKFKKFSNSIPQSQTGNSETATPTNVDLPQVIPKSENSSQPAKKAKGAAKTKQQLQKQQHPKKASFQKLNGISKGADSELSTVPSVTKTQASSSFQDSSQPAGKAEGIREPKVTGKLKQRSPKLQSSKKVAFLRQNAPPKGTDTQTPAVLSPSKTQATLKPKDHHQPLGRAKGVEKQQLPEQPFEKAAFQKQNDTPKGPQPPTVSPIRSSRPPPAKRKKSQSRGNSQLLLS
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 4447 in 28S rRNA (PubMed:26196125). Required for efficient rRNA processing and 60S ribosomal subunit biogenesis (PubMed:24120868, PubMed:36161484). Regulates pre-rRNA processing through non-catalytic complex formation with box C/D snoRNAs and facilitates the recruitment of U3 and U8 snoRNAs to pre-90S ribosomal particles and their stable assembly into snoRNP complexes (PubMed:36161484). May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation (PubMed:24120868). {ECO:0000269|PubMed:24120868, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484}.
uniprot
proteins
mass_dalton
89302
uniprot
proteins
mutagenesis
MUTAGEN 517; /note="C->A: Loss of catalytic activity. Can rescue the rRNA processing defects observed upon depletion of NOP2."; /evidence="ECO:0000269|PubMed:36161484
uniprot
proteins
post_translational_modification
PTM: Citrullinated by PADI4. {ECO:0000250|UniProtKB:Q922K7}.
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
RsmB/NOP family
uniprot
proteins
pubmed
12429849
uniprot
proteins
pubmed
1394192
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20926688
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2372471
uniprot
proteins
pubmed
23848194
uniprot
proteins
pubmed
24120868
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
2576976
uniprot
proteins
pubmed
26196125
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
36161484
uniprot
proteins
pubmed
8089149
uniprot
proteins
pubmed
9654073
uniprot
proteins
sequence_length
812
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:26196125, ECO:0000269|PubMed:36161484, ECO:0000269|PubMed:8089149}. Nucleus {ECO:0000269|PubMed:36161484}. Note=Localizes predominantly in the nucleolus and to a smaller extent in the nucleus. {ECO:0000269|PubMed:36161484}.
uniprot
proteins