MPLKIP
entrez
136647
canonical
uniprot
Q8TAP9
canonical
ensembl
ENSG00000168303
resolver
ensp
ENSP00000304553
resolver
enst
ENST00000306984
resolver
genesymbol
C7orf11
resolver
genesymbol
MPLKIP
resolver
genesymbol_syn
C7orf11
resolver
genesymbol_syn
TTDN1
resolver
hgnc
HGNC:16002
resolver
uniprot
A4D1W6
resolver
uniprot_entry
A4D1W6_HUMAN
resolver
uniprot_entry
MPLKI_HUMAN
resolver
amino_acid_sequence
MQRQNFRPPTPPYPGPGGGGWGSGSSFRGTPGGGGPRPPSPRDGYGSPHHTPPYGPRSRPYGSSHSPRHGGSFPGGRFGSPSPGGYPGSYSRSPAGSQQQFGYSPGQQQTHPQGSPRTSTPFGSGRVREKRMSNELENYFKPSMLEDPWAGLEPVSVVDISQQYSNTQTFTGKKGRYFC
uniprot
proteins
disease_involvement
DISEASE: Trichothiodystrophy 4, non-photosensitive (TTD4) [MIM:234050]: A form of trichothiodystrophy, an autosomal recessive disease characterized by sulfur-deficient brittle hair and multisystem variable abnormalities. The spectrum of clinical features varies from mild disease with only hair involvement to severe disease with cutaneous, neurologic and profound developmental defects. Ichthyosis, intellectual and developmental disabilities, decreased fertility, abnormal characteristics at birth, ocular abnormalities, short stature, and infections are common manifestations. There are both photosensitive and non-photosensitive forms of the disorder. TTD4 patients do not manifest cutaneous photosensitivity. {ECO:0000269|PubMed:15645389}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. {ECO:0000269|PubMed:17310276}.
uniprot
proteins
mass_dalton
19147
uniprot
proteins
mutagenesis
MUTAGEN 93; /note="S->A: Partially prevents phosphorylation."; /evidence="ECO:0000269|PubMed:17310276"; MUTAGEN 104; /note="S->A: Has no effect on interaction with PLK1 in mitosis. Partially prevents phosphorylation."; /evidence="ECO:0000269|PubMed:17310276"; MUTAGEN 120; /note="T->A: Abolishes interaction with PLK1 in mitosis."; /evidence="ECO:0000269|PubMed:17310276
uniprot
proteins
post_translational_modification
PTM: Phosphorylated during mitosis in the cell cycle probably by CDK1. {ECO:0000269|PubMed:17310276}.
uniprot
proteins
pubmed
11829489
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15645389
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17310276
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
179
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=The subcellular location is regulated during cell cycle. During interphase located in the nucleus. During mitosis located at the centrosome and dispersed in the cytoplasm. During telophase located in the midbody. Colocalizes with PLK1 at the centrosome in M phase.
uniprot
proteins