Kcnh8
entrez
246325
canonical
uniprot
Q9QWS8
canonical
ensembl
ENSRNOG00000058626
resolver
ensp
ENSRNOP00000074122
resolver
genesymbol
Kcnh8
resolver
genesymbol_syn
Elk1
resolver
genesymbol_syn
Elk3
resolver
uniprot
O88877
resolver
uniprot_entry
KCNH8_RAT
resolver
uniprot_sec
O88877
resolver
amino_acid_sequence
MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEVMQKSCSCKFLFGVETNEQLMLQIEKSLEEKVEFKGEIMFYKKNGAPFWCLLDIVPIKNEKGDVVLFLASFKDITDTKVKITSEDKKEDRAKGRSRAGSHFDSARRRSRAVLYHISGHLQRREKNKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNEDLSTTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVTTWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEILQLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLGLYPEYAHKFVEDIQHDLTYNLREGHESDVISRLSNKSTVPQAEPKGNGSIKKRLPSIVEDEEEEEVEEEETTSLSPIYTRGSSVSHSKKTGSSKSYLGLSLKQLTSGTVPFHSPIRVSSANSPKTKQEADPPNHGTRKEKNLKVQLCSLGTAGTPELSPRIVDGIEDGNSSEETQTFDFGSEQIRPEPRISPSLGESEIGAAFLFIKAEETKQQINKLNSEVTTLTQEVSQLGKDMRSIMQLLENILSPQQPSQFCSLHPTSICPSRESFQTRVSWSAHQPCLHLQANGAHLYHGNVTSDIWSVDPSLVGSNPQRTEAHEQSPVDSELHHSPNLAYSPSHCQVIQEGHLQFLRCISPHSDTTLTPLQSISATLSSSVCSSSETSLHLVLPSRSEEGSITHGPVSSFSLENLPGSWDREGMMSASTEPLENFPVEVVTSTADVKDSKAINV
uniprot
proteins
function
FUNCTION: Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents (PubMed:9714851). Elicits a slowly activating, non-inactivating and slowly deactivation outwards potassium current at depolarizating voltages from -30 mV to +50mV (PubMed:9714851). Shows no obvious change in the activation rate from different holding potentials (PubMed:9714851). Activation is strongly dependent on the pH of the external solution (PubMed:9714851). {ECO:0000269|PubMed:9714851}.
uniprot
proteins
mass_dalton
123231
uniprot
proteins
protein_family
H (Eag) (TC 1.A.1.20) subfamily
uniprot
proteins
protein_family
Kv12.1/KCNH8 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
10718922
uniprot
proteins
pubmed
11425889
uniprot
proteins
pubmed
9714851
uniprot
proteins
pubmed
9824707
uniprot
proteins
sequence_length
1102
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 226..246; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 256..276; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 299..319; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 328..348; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 354..374; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 449..469; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins