Sdha
entrez
66945
canonical
uniprot
Q8K2B3
canonical
ensembl
ENSMUSG00000021577
resolver
ensp
ENSMUSP00000022062
resolver
enst
ENSMUST00000022062
resolver
genesymbol
Sdha
resolver
uniprot
Q0QF19
resolver
uniprot
Q3UH25
resolver
uniprot
Q3UKP7
resolver
uniprot
Q3V4B1
resolver
uniprot
Q921P5
resolver
uniprot
Q9Z1Z4
resolver
uniprot_entry
SDHA_MOUSE
resolver
uniprot_sec
Q0QF19
resolver
uniprot_sec
Q3UH25
resolver
uniprot_sec
Q3UKP7
resolver
uniprot_sec
Q3V4B1
resolver
uniprot_sec
Q921P5
resolver
uniprot_sec
Q9Z1Z4
resolver
activity_regulation
ACTIVITY REGULATION: Enol-oxaloacetate inhibits the succinate dehydrogenase activity. {ECO:0000250|UniProtKB:P31039}.
uniprot
proteins
amino_acid_sequence
MAGVGAVSRLLRGRRLALTGAWPGTLQKQTCGFHFSVGENKKASAKVSDAISTQYPVVDHEFDAVVVGAGGAGLRAAFGLSEAGFNTACLTKLFPTRSHTVAAQGGINAALGNMEEDNWRWHFYDTVKGSDWLGDQDAIHYMTEQAPASVVELENYGMPFSRTEDGKIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHTLYGRSLRYDTSYFVEYFALDLLMENGECRGVIALCIEDGSIHRIRAKNTVIATGGYGRTYFSCTSAHTSTGDGTAMVTRAGLPCQDLEFVQFHPTGIYGAGCLITEGCRGEGGILINSQGERFMERYAPVAKDLASRDVVSRSMTLEIREGRGCGPEKDHVYLQLHHLPPEQLATRLPGISETAMIFAGVDVTKEPIPVLPTVHYNMGGIPTNYKGQVLKHVNGQDQIVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIAESCRPGDKVPSIKANAGEESVMNLDKLRFADGSIRTSELRLNMQKSMQNHAAVFRVGSVLQEGCEKISQLYGDLKHLKTFDRGMVWNTDLVETLELQNLMLCALQTIYGAEARKESRGAHAREDYKVRVDEYDYSKPIQGQQKKPFGEHWRKHTLSYVDIKTGKVTLEYRPVIDKTLNEADCATVPPAIRSY
uniprot
proteins
ec_number
1.1.5.-
uniprot
proteins
ec_number
1.3.5.1
uniprot
proteins
function
FUNCTION: Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity). SDH also oxidizes malate to the non-canonical enol form of oxaloacetate, enol-oxaloacetate. Enol-oxaloacetate, which is a potent inhibitor of the succinate dehydrogenase activity, is further isomerized into keto-oxaloacetate (By similarity). Can act as a tumor suppressor (By similarity). {ECO:0000250|UniProtKB:P31039, ECO:0000250|UniProtKB:P31040}.
uniprot
proteins
mass_dalton
72585
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1. {ECO:0000250|UniProtKB:P31040}.
uniprot
proteins
post_translational_modification
PTM: Acetylation of Lys-498 and Lys-538 is observed in liver mitochondria from fasted mice but not from fed mice. Deacetylated by SIRT3. {ECO:0000269|PubMed:21858060}.; PTM: Phosphorylation at Tyr-215 is important for efficient electron transfer in complex II and the prevention of ROS generation. {ECO:0000250|UniProtKB:P31040}.
uniprot
proteins
protein_family
FAD-dependent oxidoreductase 2 family
uniprot
proteins
protein_family
FRD/SDH subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16751257
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21858060
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
664
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q0QF01}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q0QF01}; Matrix side {ECO:0000250|UniProtKB:Q0QF01}.
uniprot
proteins