Duox2
entrez
79107
canonical
uniprot
Q9ES45
canonical
ensembl
ENSRNOG00000017395
resolver
ensp
ENSRNOP00000023939
resolver
genesymbol
Duox2
resolver
genesymbol_syn
Lnox2
resolver
genesymbol_syn
Thox2
resolver
uniprot
Q811Y4
resolver
uniprot_entry
DUOX2_RAT
resolver
uniprot_sec
Q811Y4
resolver
activity_regulation
ACTIVITY REGULATION: Peroxidase activity is inhibited by aminobenzohydrazide (By similarity). The NADPH oxidase activity is calcium-dependent (By similarity). {ECO:0000250|UniProtKB:Q9NRD8, ECO:0000250|UniProtKB:Q9NRD9}.
uniprot
proteins
amino_acid_sequence
MLPTSLKTLVLLGALLTGPLGPAGGQDAPSLPREVQRYDGWFNNLKYHQRGAAGSQLRRLVPANYADGVYQALQEPLLPNARLLSDAVSKGKAGLPSAHNRTVLGLFFGYHVLSDLVSVETPGCPAEFLNIYIPRGDPVFDPDKRGNVVLPFQRSRWDRSTGQSPSNPRDLTNQVTGWLDGSAIYGSSHSWSDTLRSFSGGQLASGPDPAFPRNSQNSLLMWMAPDPATGQGGPQGLYAFGAQRGNREPFLQALGLLWFRYHNLCAKRLAQEHPHWGDEELFQHARKRVIATYQNIALYQWLPSFLQKTPPEYSGYRPFMDPSISPEFVAASEQFLSTMVPPGVYMRNSSCHFREFPKEGSSSSPALRVCNNYWIRENPSLKTAQDVDQLLLGMASQISELEDRIVIEDLRDYWPGPDRYSRTDYVASSIQSGRDMGLPSYSQALQALGLEPPKNWSALNPKVDPQVLEATAALYNQDLSRLELFLGGLLESHGDPGPLFSNIILDQFVRLRDGDRYWFENTRNGLFSKEEIAEIRNTTLRDVLVAVSNVDPSALQPNVFFWQEGAPCPQPQQLTTEGLPQCVPVTVIDYFEGSGAGYGVTLLAVCCFPVVSLIIAWVVARFRNRERKMLLKKGKESLKKQTASDGVPAMEWPGPKESSYPVTVQLLPDRSLKVLDKRLTVLRTIQLQPTQQVNLILSSSHGRRTLLLKIPKEYDLVLMFNSEEDRDAFVQLLQDLCVCSTPGLRIAEMDEKELLRKAVTKQQRAGILEIFFRQLFAQVLDINQADAGTLPLDSSQQVREALTCELSRAEFADSLGLKPQDMFVESMFSLADKDGNGYISFREFLDILVVFMKGSPQDKSRLMFTMYDLDGNGFLSKEEFFTMMRSFIEISNNCLSKDQLAEVVESMFRESGFQDKEELTWEDFHFMLRDHDSDLRFTQLCVKGGAGGTGDIFKQSNACRVSFLTRTPGNRVMAPSPRLYTEALQEKMQRGFLAQKLKQFKRFVENYRRHIVCVTIFSAICAGLFADRAYYYGFASPPTDIEETTYVGIILSRGTAASISFMFSYILLTMCRNLITFLRETFLNRYIPFDAAVDFHRWIAMAAVVLAVVHSLGHAVNVYIFSVSPLSLMTCVFPSVFVNDGSKLPPKYYWWFFETVPGMTGVLLLLVLAIMYVFASHHFRRHSFRGFWLTHHLYVVLYALIIIHGSYALIQLPSFHIYFLVPAIIYVGDKLVSLSRKKVEISVVKVELLPSGVTYLQFQRPKTFEYKSGQWVRIACLSLGTNEYHPFTLTSAPHEDTLSLHIRAVGPWTTRLREIYSPPVGGTSARYPKLYLDGPFGEGHQEWHKFEVSVLVGGGIGVTPFASILKDLVFKSSMGTQMLCKKIYFIWVTRTQRQFEWLADIIREVEENGSRDLVSVHIYITQLAEKFDLRTTMLYICERHFQKVLNRSLFTGLRSVTHFGRPPFELFLDSLQEVHPQVHKIGVFSCGPPGMTKNVEKACQLINRQDRAHFVHHYENF
uniprot
proteins
ec_number
1.-.-.-
uniprot
proteins
ec_number
1.11.1.-
uniprot
proteins
ec_number
1.6.3.1
uniprot
proteins
function
FUNCTION: Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormone synthesis. Also required for lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. Synthesizes NAADP from its reduced NAADPH form which promotes Ca(2+) signaling during T cell activation. May have its own peroxidase activity through its N-terminal peroxidase-like domain. {ECO:0000250|UniProtKB:Q9NRD8}.
uniprot
proteins
mass_dalton
171558
uniprot
proteins
pathway_participation
PATHWAY: Hormone biosynthesis; thyroid hormone biosynthesis.
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250}.
uniprot
proteins
protein_family
Peroxidase family
uniprot
proteins
pubmed
11032719
uniprot
proteins
pubmed
12538618
uniprot
proteins
pubmed
12824283
uniprot
proteins
sequence_length
1517
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q9NRD8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NRD8}. Cell junction {ECO:0000250|UniProtKB:Q9NRD8}. Note=Localizes to the apical membrane of epithelial cells. Localizes on internal membrane structures under resting conditions, translocates to the plasma membrane and cell-cell junctions upon challenge with enteric pathogens. {ECO:0000250|UniProtKB:Q9NRD8}.
uniprot
proteins
transmembrane_region
TRANSMEM 600..620; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1011..1031; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1047..1067; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1101..1121; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1155..1175; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1186..1206; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1208..1228; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins