Pax6
entrez
25509
canonical
uniprot
P63016
canonical
ensembl
ENSRNOG00000004410
resolver
ensembl
ENSRNOG00055022908
resolver
ensembl
ENSRNOG00060002262
resolver
ensembl
ENSRNOG00065015473
resolver
ensp
ENSRNOP00000005882
resolver
ensp
ENSRNOP00000071013
resolver
genesymbol
Pax6
resolver
genesymbol_syn
Pax-6
resolver
genesymbol_syn
Sey
resolver
uniprot
A1A5N7
resolver
uniprot
P32117
resolver
uniprot
P70601
resolver
uniprot
Q62222
resolver
uniprot
Q64037
resolver
uniprot
Q6QHS5
resolver
uniprot
Q701Q8
resolver
uniprot_entry
PAX6_RAT
resolver
uniprot_sec
A1A5N7
resolver
uniprot_sec
P32117
resolver
uniprot_sec
P70601
resolver
uniprot_sec
Q62222
resolver
uniprot_sec
Q64037
resolver
uniprot_sec
Q6QHS5
resolver
uniprot_sec
Q701Q8
resolver
amino_acid_sequence
MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQEGQGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIPQPTTPVSSFTSGSMLGRTDTALTNTYSALPPMPSFTMANNLPMQPPVPSQTSSYSCMLPTSPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTTSTGLISPGVSVPVQVPGSEPDMSQYWPRLQ
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Pax6 are the cause of a condition known as small eye (Sey) which results in the complete lack of eyes and nasal primordia. {ECO:0000269|PubMed:7981749}.
uniprot
proteins
function
FUNCTION: Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells. Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters (By similarity). Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains. Acts as a transcriptional repressor of NFATC1-mediated gene expression (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P63015, ECO:0000269|PubMed:11880342}.
uniprot
proteins
mass_dalton
46754
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by TRIM11, leading to ubiquitination and proteasomal degradation. {ECO:0000250}.
uniprot
proteins
protein_family
Paired homeobox family
uniprot
proteins
pubmed
11880342
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24114637
uniprot
proteins
pubmed
24952136
uniprot
proteins
pubmed
7981749
uniprot
proteins
sequence_length
422
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P63015}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00381, ECO:0000269|PubMed:24952136}.; SUBCELLULAR LOCATION: [Isoform 5a]: Nucleus {ECO:0000269|PubMed:24952136}.
uniprot
proteins