MSLN
entrez
10232
canonical
uniprot
Q13421
canonical
ensembl
ENSG00000102854
resolver
ensp
ENSP00000372313
resolver
ensp
ENSP00000442965
resolver
ensp
ENSP00000456008
resolver
genesymbol
MSLN
resolver
genesymbol_syn
MPF
resolver
hgnc
HGNC:7371
resolver
uniprot
D3DU65
resolver
uniprot
Q14859
resolver
uniprot
Q4VQD5
resolver
uniprot
Q96GR6
resolver
uniprot
Q96KJ5
resolver
uniprot
Q9BR17
resolver
uniprot
Q9BTR2
resolver
uniprot
Q9UCB2
resolver
uniprot
Q9UK57
resolver
uniprot_entry
MSLN_HUMAN
resolver
uniprot_sec
D3DU65
resolver
uniprot_sec
Q14859
resolver
uniprot_sec
Q4VQD5
resolver
uniprot_sec
Q96GR6
resolver
uniprot_sec
Q96KJ5
resolver
uniprot_sec
Q9BR17
resolver
uniprot_sec
Q9BTR2
resolver
uniprot_sec
Q9UCB2
resolver
uniprot_sec
Q9UK57
resolver
amino_acid_sequence
MALPTARPLLGSCGTPALGSLLFLLFSLGWVQPSRTLAGETGQEAAPLDGVLANPPNISSLSPRQLLGFPCAEVSGLSTERVRELAVALAQKNVKLSTEQLRCLAHRLSEPPEDLDALPLDLLLFLNPDAFSGPQACTRFFSRITKANVDLLPRGAPERQRLLPAALACWGVRGSLLSEADVRALGGLACDLPGRFVAESAEVLLPRLVSCPGPLDQDQQEAARAALQGGGPPYGPPSTWSVSTMDALRGLLPVLGQPIIRSIPQGIVAAWRQRSSRDPSWRQPERTILRPRFRREVEKTACPSGKKAREIDESLIFYKKWELEACVDAALLATQMDRVNAIPFTYEQLDVLKHKLDELYPQGYPESVIQHLGYLFLKMSPEDIRKWNVTSLETLKALLEVNKGHEMSPQVATLIDRFVKGRGQLDKDTLDTLTAFYPGYLCSLSPEELSSVPPSSIWAVRPQDLDTCDPRQLDVLYPKARLAFQNMNGSEYFVKIQSFLGGAPTEDLKALSQQNVSMDLATFMKLRTDAVLPLTVAEVQKLLGPHVEGLKAEERHRPVRDWILRQRQDDLDTLGLGLQGGIPNGYLVLDLSMQEALSGTPCLLGPGPVLTVLALLLASTLA
uniprot
proteins
disease_involvement
DISEASE: Note=Antibodies against MSLN are detected in patients with mesothelioma and ovarian cancer. {ECO:0000269|PubMed:15897581}.
uniprot
proteins
function
FUNCTION: Membrane-anchored forms may play a role in cellular adhesion.; FUNCTION: Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.
uniprot
proteins
mass_dalton
68070
uniprot
proteins
post_translational_modification
PTM: Both MPF and the cleaved form of mesothelin are N-glycosylated. {ECO:0000269|PubMed:16857795, ECO:0000269|PubMed:8288629, ECO:0000269|PubMed:8552591}.; PTM: Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin. {ECO:0000269|PubMed:8552591}.
uniprot
proteins
protein_family
Mesothelin family
uniprot
proteins
pubmed
10500211
uniprot
proteins
pubmed
11157797
uniprot
proteins
pubmed
14676194
uniprot
proteins
pubmed
15140265
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
15897581
uniprot
proteins
pubmed
16857795
uniprot
proteins
pubmed
22787150
uniprot
proteins
pubmed
25946035
uniprot
proteins
pubmed
26091039
uniprot
proteins
pubmed
7665620
uniprot
proteins
pubmed
8288629
uniprot
proteins
pubmed
8552591
uniprot
proteins
sequence_length
622
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor. Golgi apparatus.; SUBCELLULAR LOCATION: [Megakaryocyte-potentiating factor]: Secreted.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted.
uniprot
proteins