Lpcat4
entrez
99010
canonical
uniprot
Q6NVG1
canonical
ensembl
ENSMUSG00000027134
resolver
ensp
ENSMUSP00000028554
resolver
enst
ENSMUST00000028554
resolver
genesymbol
Lpcat4
resolver
genesymbol_syn
Agpat7
resolver
genesymbol_syn
Aytl3
resolver
uniprot
Q66JP7
resolver
uniprot_entry
LPCT4_MOUSE
resolver
uniprot_sec
Q66JP7
resolver
amino_acid_sequence
MSQGSPGAWAPLDPTSGSSASPNPFVHELHLSGLQRVKFCLLGVLLAPIRVLLAFIVLFLLWPFAWLQVAGLTEEQLQEPITGWRKTVCHNGVLGLSRLLFFLLGFLRIRVRGQRASRLEAPVLVAAPHSTFFDPIVLLPCDLPKVVSRAENLSVPVIGALLRFNQAILVSRHDPASRRRVVEEVRRRATSGGKWPQVLFFPEGTCSNKKALLKFKPGAFIAGVPVQPVLIRYPNSLDTTSWAWRGPGVLKVLWLTASQPCSIVDVEFLPVYQPSLEESKDPTLYANNVQRVMAQALGIPATECEFVGSLPVIVVGQLKVALEPQLWELAKVLQKAGLSPGFVDMGAEPGRSRMISQEAFAQQLQLSDPQTVAGAFSYFQQDAKGLVDFRNVALALAALDGGRSLEELTRLAFELFAEEQAEGSDRLLYKDGFSTILHLLLGSPRPAATTLHAELCQPGCSQGLSLCQFQNFSLHDPLYGKLFSAYLRPPHKPRSTSQIPNASSPSSPTALANGTVQAPKQKGD
uniprot
proteins
ec_number
2.3.1.121
uniprot
proteins
ec_number
2.3.1.23
uniprot
proteins
ec_number
2.3.1.63
uniprot
proteins
ec_number
2.3.1.n6
uniprot
proteins
ec_number
2.3.1.n7
uniprot
proteins
function
FUNCTION: Acyl-CoA-dependent lysophospholipid acyltransferase involved in phospholipid remodeling. Displays acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, lysophosphatidylcholine to phosphatidycholine, 1-alkenyl-lysophatidylethanolamine to 1-alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl-phosphatidylcholine, respectively (By similarity) (PubMed:18156367). Can use various medium- and long-chain, saturated and unsaturated fatty acyl-CoAs, displaying the highest activity toward unsaturated fatty acyl-CoAs (By similarity). Catalysis the biosynthesis of atypical phospholipids carrying unsaturated fatty acids esterified at the sn-1 position of the glycerol backbone. Transfers unsaturated fatty acyl chains to the sn-1 position of lysophosphatidylcholines, lysophosphatidylethanolamines and lysophosphatidylserines with lysophosphatidylcholines being the preferred substrates. Contributes to the remodeling of brain phosphatidylcholine species with unsaturated fatty acyl chains such as C18:1, C18:2, C20:4 and C22:6 at the sn-1 position (By similarity) (PubMed:41740885). Has no apparent acyltransferase activity toward lysophosphatidylinositols, lysophosphatidic acids, lysophosphatidylglycerols, glycerol-3-phosphates or diacylglycerols. Has no acetyltransferase activity toward lysoplatelet-activating factor (lyso-PAF) (By similarity). {ECO:0000250|UniProtKB:Q643R3, ECO:0000269|PubMed:18156367, ECO:0000269|PubMed:41740885}.
uniprot
proteins
mass_dalton
57143
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; phospholipid metabolism. {ECO:0000269|PubMed:41740885}.
uniprot
proteins
protein_family
1-acyl-sn-glycerol-3-phosphate acyltransferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18156367
uniprot
proteins
pubmed
18458083
uniprot
proteins
pubmed
41740885
uniprot
proteins
sequence_length
524
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q643R3}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..62; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 87..107; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins