JPT1
entrez
51155
canonical
uniprot
Q9UK76
canonical
ensembl
ENSG00000189159
resolver
ensp
ENSP00000348316
resolver
ensp
ENSP00000387059
resolver
ensp
ENSP00000462478
resolver
ensp
ENSP00000462834
resolver
ensp
ENSP00000464266
resolver
genesymbol
JPT1
resolver
genesymbol_syn
ARM2
resolver
genesymbol_syn
HN1
resolver
hgnc
HGNC:14569
resolver
uniprot
B2R6K3
resolver
uniprot
Q53FG7
resolver
uniprot
Q7Z2D2
resolver
uniprot
Q7Z2F0
resolver
uniprot_entry
JUPI1_HUMAN
resolver
uniprot_sec
B2R6K3
resolver
uniprot_sec
Q53FG7
resolver
uniprot_sec
Q7Z2D2
resolver
uniprot_sec
Q7Z2F0
resolver
amino_acid_sequence
MTTTTTFKGVDPNSRNSSRVLRPPGGGSNFSLGFDEPTEQPVRKNKMASNIFGTPEENQASWAKSAGAKSSGGREDLESSGLQRRNSSEASSGDFLDLKGEGDIHENVDTDLPGSLGQSEEKPVPAAPVPSPVAPAPVPSRRNPPGGKSSLVLG
uniprot
proteins
function
FUNCTION: Modulates negatively AKT-mediated GSK3B signaling (PubMed:21323578, PubMed:22155408). Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (PubMed:25169422). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteasomal degradation (PubMed:22155408). {ECO:0000269|PubMed:21323578, ECO:0000269|PubMed:22155408, ECO:0000269|PubMed:25169422, ECO:0000269|PubMed:25450365}.
uniprot
proteins
mass_dalton
16015
uniprot
proteins
protein_family
JUPITER family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15094197
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16602700
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21323578
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22155408
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25169422
uniprot
proteins
pubmed
25450365
uniprot
proteins
sequence_length
154
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21323578}. Cytoplasm {ECO:0000269|PubMed:25169422}.
uniprot
proteins