Selenok
entrez
290549
canonical
uniprot
P59798
canonical
ensembl
ENSRNOG00000078830
resolver
ensembl
ENSRNOG00055020634
resolver
ensembl
ENSRNOG00060013604
resolver
ensembl
ENSRNOG00065015314
resolver
ensp
ENSRNOP00000102170
resolver
ensp
ENSRNOP00055028541
resolver
ensp
ENSRNOP00060018423
resolver
ensp
ENSRNOP00065019920
resolver
enst
ENSRNOT00055035208
resolver
enst
ENSRNOT00060023224
resolver
enst
ENSRNOT00065025395
resolver
genesymbol
Selenok
resolver
genesymbol_syn
Selk
resolver
uniprot
Q5I0Q3
resolver
uniprot_entry
SELK_RAT
resolver
uniprot_sec
Q5I0Q3
resolver
amino_acid_sequence
MVYISNGQVLDSRNQSPWRLSFITDFFWGIAEFVVFFFKTLLQQDVKKRRGYGGSSDSRYDDGRGPPGNPPRRMGRISHLRGPSPPPMAGGUGR
uniprot
proteins
function
FUNCTION: Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins (By similarity). Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function. Plays a role in protection of cells from ER stress-induced apoptosis. Protects cells from oxidative stress when overexpressed in cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:Q9JLJ1, ECO:0000250|UniProtKB:Q9Y6D0}.
uniprot
proteins
mass_dalton
10626
uniprot
proteins
post_translational_modification
PTM: Cleaved by CAPN2/m-calpain in resting macrophages but not in activated macrophages. Macrophage activation up-regulates expression of the calpain inhibitor CAST/calpastatin, resulting in inhibition of CAPN2 activity (By similarity). {ECO:0000250|UniProtKB:Q9JLJ1}.; PTM: Truncated SELENOK proteins produced by failed UGA/Sec decoding are ubiquitinated by the CRL2(KLHDC2) complex, which recognizes the diglycine (Gly-Gly) at the C-terminus of truncated SELENOK proteins. {ECO:0000250|UniProtKB:Q9Y6D0}.
uniprot
proteins
protein_family
Selenoprotein K family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
94
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Y6D0}; Single-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9Y6D0}; Single-pass membrane protein {ECO:0000255}. Note=Probably mainly localized in the ER. {ECO:0000250|UniProtKB:Q9Y6D0}.
uniprot
proteins
transmembrane_region
TRANSMEM 20..42; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins