Slc17a7
entrez
116638
canonical
uniprot
Q62634
canonical
ensembl
ENSRNOG00000020650
resolver
ensembl
ENSRNOG00055005694
resolver
ensembl
ENSRNOG00060008397
resolver
ensembl
ENSRNOG00065028761
resolver
ensp
ENSRNOP00000063604
resolver
ensp
ENSRNOP00000099148
resolver
genesymbol
Slc17a7
resolver
genesymbol_syn
Bnpi
resolver
genesymbol_syn
Vglut1
resolver
uniprot
A9LRT0
resolver
uniprot_entry
VGLU1_RAT
resolver
uniprot_sec
A9LRT0
resolver
activity_regulation
ACTIVITY REGULATION: Chloride channel activity is allosterically activated by lumenal H(+) and Cl(-) leading to synaptic vesicles acidification (PubMed:27133463). The L-glutamate transport activity is allosterically activated by lumenal H(+) and Cl(-) (PubMed:19169251, PubMed:27133463). The allosteric activation by H(+) efficiently prevents non-vesicular efflux across the plasma membrane, thereby restricting L-glutamate transport activity to acidic membranes such as synaptic vesicles (PubMed:27133463). {ECO:0000269|PubMed:19169251, ECO:0000269|PubMed:27133463}.
uniprot
proteins
amino_acid_sequence
MEFRQEEFRKLAGRALGRLHRLLEKRQEGAETLELSADGRPVTTHTRDPPVVDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVSMVNNSTTHRGGHVVVQKAQFNWDPETVGLIHGSFFWGYIVTQIPGGFICQKFAANRVFGFAIVATSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTAFCGSYAGAVVAMPLAGVLVQYSGWSSVFYVYGSFGIFWYLFWLLVSYESPALHPSISEEERKYIEDAIGESAKLMNPVTKFNTPWRRFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGLVSALPHLVMTIIVPIGGQIADFLRSRHIMSTTNVRKLMNCGGFGMEATLLLVVGYSHSKGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKHKTREEWQYVFLIASLVHYGGVIFYGVFASGEKQPWAEPEEMSEEKCGFVGHDQLAGSDESEMEDEVEPPGAPPAPPPSYGATHSTVQPPRPPPPVRDY
uniprot
proteins
function
FUNCTION: Multifunctional transporter that transports L-glutamate as well as multiple ions such as chloride, proton, potassium, sodium and phosphate (PubMed:10938000, PubMed:11001057, PubMed:11698619, PubMed:18080752, PubMed:19169251, PubMed:25433636, PubMed:27133463, PubMed:29642010, PubMed:33440152, PubMed:8202535). At the synaptic vesicle membrane, mainly functions as an uniporter which transports preferentially L-glutamate but also phosphate from the cytoplasm into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells (PubMed:10938000, PubMed:11001057, PubMed:11698619, PubMed:18080752, PubMed:29642010). The L-glutamate or phosphate uniporter activity is electrogenic and is driven by the proton electrochemical gradient, mainly by the electrical gradient established by the vacuolar H(+)-ATPase across the synaptic vesicle membrane (PubMed:29642010). In addition, functions as a chloride channel that allows a chloride permeation through the synaptic vesicle membrane that affects the proton electrochemical gradient and promotes synaptic vesicles acidification (PubMed:10938000, PubMed:19169251, PubMed:25433636, PubMed:27133463, PubMed:29642010). Moreover, may function as a K(+)/H(+) antiport allowing to maintain the electrical gradient and to decrease chemical gradient and therefore sustain vesicular glutamate uptake (PubMed:25433636). The vesicular K(+)/H(+) antiport activity is electroneutral (PubMed:25433636). At the plasma membrane, following exocytosis, functions as a symporter of Na(+) and phosphate from the extracellular space to the cytoplasm allowing synaptic phosphate homeostasis regulation (PubMed:29642010, PubMed:33440152, PubMed:8202535). The symporter activity is driven by an inside negative membrane potential and is electrogenic (PubMed:29642010). Is necessary for synaptic signaling of visual-evoked responses from photoreceptors (By similarity). {ECO:0000250|UniProtKB:Q3TXX4, ECO:0000269|PubMed:10938000, ECO:0000269|PubMed:11001057, ECO:0000269|PubMed:11698619, ECO:0000269|PubMed:18080752, ECO:0000269|PubMed:19169251, ECO:0000269|PubMed:25433636, ECO:0000269|PubMed:27133463, ECO:0000269|PubMed:29642010, ECO:0000269|PubMed:33440152, ECO:0000269|PubMed:8202535}.
uniprot
proteins
mass_dalton
61665
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Sodium/anion cotransporter family
uniprot
proteins
protein_family
VGLUT subfamily
uniprot
proteins
pubmed
10938000
uniprot
proteins
pubmed
11001057
uniprot
proteins
pubmed
11502256
uniprot
proteins
pubmed
11698619
uniprot
proteins
pubmed
11698620
uniprot
proteins
pubmed
16987242
uniprot
proteins
pubmed
17110340
uniprot
proteins
pubmed
18080752
uniprot
proteins
pubmed
18278042
uniprot
proteins
pubmed
19169251
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
25433636
uniprot
proteins
pubmed
27133463
uniprot
proteins
pubmed
29642010
uniprot
proteins
pubmed
33440152
uniprot
proteins
pubmed
8202535
uniprot
proteins
sequence_length
560
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:11001057, ECO:0000269|PubMed:11698619}. Cell membrane {ECO:0000305|PubMed:29642010}; Multi-pass membrane protein {ECO:0000305}. Synapse, synaptosome {ECO:0000269|PubMed:11698619}.
uniprot
proteins
transmembrane_region
TRANSMEM 64..84; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 117..137; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 141..161; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 170..190; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 209..229; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 237..257; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 303..323; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 342..362; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 379..399; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 402..422; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 436..456; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 470..490; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins