Ttf1
entrez
22130
canonical
uniprot
Q62187
canonical
ensembl
ENSMUSG00000026803
resolver
ensp
ENSMUSP00000097809
resolver
ensp
ENSMUSP00000249666
resolver
ensp
ENSMUSP00000249667
resolver
enst
ENSMUST00000100237
resolver
genesymbol
Ttf1
resolver
uniprot
Q3TQG6
resolver
uniprot
Q9JKK5
resolver
uniprot_entry
Q3TQG6_MOUSE
resolver
uniprot_entry
TTF1_MOUSE
resolver
uniprot_sec
Q9JKK5
resolver
amino_acid_sequence
MKGGTSKFKTHTETLYKKKKWSSVSEKRPQKCPSQCLESKQPQVSVLGKRRRASQTPAQETLESEWPQKAKRKKRRREPQTPAQETLESEWPQKAKKKKRRGEPQTPTQESLESEQPPVSLLGKRRRESQTPAQENSESEQPRKAKRRRKKRKGSQQPTSSLLKTPETFLKAKKTTSAHKKKKNSVLEVDMETGIILVDKENMENLLETSRKDVDIVYVDMSKGQRSAKVRETGELPAAKPQEHGCRELLGDVRSRKKQKHLQKVAPWDVVQGSQPESISLPPSEPLSSEDLEGKSTEAAVFCKKKSKKNVFRSQELEPIPDSLDDSETISERLDSTHHGGAVGAGEECESTKESHSIKKKSKKKKHKSVALATSSDSASVTDSKAKNALVDSSEGSGAVREEDVDHRPAEAEAQACSTEKHREAMQRLEPTHEEESNSESASNSAARHISEDRRESDDSDVDLGSAVRQLREFIPDIQERAATTIRRMYRDDLGRFKEFKAQGVAIRFGKFSAKENKQIEKNVQDFLSLTGIESADKLLYTDRYPEEKTLITNLKRKHAFRLHIGKGIARPWKLVYYRAKKIFDVNNYKGRYNEEDTKKLKAYHSLHGNDWKKIGAMVARSSLSVALKFSQIGGTRNQGAWSKAETQRLIKAVEDVILKKMSPQELRELDSKLQEDPEGRLSIVREKLYKGISWVEVEARVETRNWMQCKSKWTEILTKRMTHGGFVYRGVNALQAKITLIERLYELNVNDANEIDWEDLASAIGDVPPPFVQAKFYKLKAACVPFWQKKTFPEIIDYLYKNSLPLLKEKLDKKMKKKDGQIQTPAAPKQDFLFKDIFHCDDDSDEGSPEEPSASDVQ
uniprot
proteins
function
FUNCTION: Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin (PubMed:15292447, PubMed:7720715, PubMed:9049305, PubMed:9267035). Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription (PubMed:15292447, PubMed:20513429). Interaction with BAZ2A/TIP5 recovers DNA-binding activity (PubMed:15292447). {ECO:0000269|PubMed:15292447, ECO:0000269|PubMed:20513429, ECO:0000269|PubMed:7720715, ECO:0000269|PubMed:9049305, ECO:0000269|PubMed:9267035}.
uniprot
proteins
mass_dalton
97723
uniprot
proteins
pubmed
15292447
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
20513429
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27528195
uniprot
proteins
pubmed
7720715
uniprot
proteins
pubmed
9049305
uniprot
proteins
pubmed
9092622
uniprot
proteins
pubmed
9267035
uniprot
proteins
pubmed
9582279
uniprot
proteins
sequence_length
859
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:7720715}. Nucleus, nucleolus {ECO:0000269|PubMed:20513429, ECO:0000269|PubMed:7720715}. Nucleus, nucleoplasm {ECO:0000269|PubMed:20513429}. Note=May be localized to the nucleolus in an NPM1/B23-dependent manner (PubMed:20513429). May be displaced from the nucleolus into the nucleoplasm in an CDKN2A/ARF-dependent manner (PubMed:20513429). May shuttle back and forth from nucleoplasm to nucleolus (PubMed:20513429). {ECO:0000269|PubMed:20513429}.
uniprot
proteins