AANAT
entrez
15
canonical
uniprot
Q16613
canonical
ensembl
ENSG00000129673
resolver
ensp
ENSP00000250615
resolver
ensp
ENSP00000376282
resolver
genesymbol
AANAT
resolver
genesymbol_syn
SNAT
resolver
hgnc
HGNC:19
resolver
uniprot
A0AVF2
resolver
uniprot
F1T0I5
resolver
uniprot
J3KMZ5
resolver
uniprot
Q562F4
resolver
uniprot_entry
F1T0I5_HUMAN
resolver
uniprot_entry
SNAT_HUMAN
resolver
uniprot_sec
A0AVF2
resolver
uniprot_sec
J3KMZ5
resolver
uniprot_sec
Q562F4
resolver
amino_acid_sequence
MSTQSTHPLKPEAPRLPPGIPESPSCQRRHTLPASEFRCLTPEDAVSAFEIEREAFISVLGVCPLYLDEIRHFLTLCPELSLGWFEEGCLVAFIIGSLWDKERLMQESLTLHRSGGHIAHLHVLAVHRAFRQQGRGPILLWRYLHHLGSQPAVRRAALMCEDALVPFYERFSFHAVGPCAITVGSLTFMELHCSLRGHPFLRRNSGC
uniprot
proteins
ec_number
2.3.1.87
uniprot
proteins
function
FUNCTION: Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin. {ECO:0000269|PubMed:11313340, ECO:0000305}.
uniprot
proteins
mass_dalton
23344
uniprot
proteins
mutagenesis
MUTAGEN 31; /note="T->A: Loss of activation by cAMP."; /evidence="ECO:0000269|PubMed:11427721
uniprot
proteins
pathway_participation
PATHWAY: Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2.
uniprot
proteins
post_translational_modification
PTM: cAMP-dependent phosphorylation on both N-terminal Thr-31 and C-terminal Ser-205 regulates AANAT activity by promoting interaction with 14-3-3 proteins.
uniprot
proteins
protein_family
AANAT subfamily
uniprot
proteins
protein_family
Acetyltransferase family
uniprot
proteins
pubmed
11313340
uniprot
proteins
pubmed
11427721
uniprot
proteins
pubmed
12736803
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
18212399
uniprot
proteins
pubmed
8661026
uniprot
proteins
sequence_length
207
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11313340}.
uniprot
proteins