DCLRE1A
entrez
9937
canonical
uniprot
Q6PJP8
canonical
ensembl
ENSG00000198924
resolver
ensp
ENSP00000355185
resolver
ensp
ENSP00000358311
resolver
ensp
ENSP00000522080
resolver
enst
ENST00000361384
resolver
enst
ENST00000369305
resolver
enst
ENST00000852021
resolver
genesymbol
DCLRE1A
resolver
genesymbol_syn
KIAA0086
resolver
genesymbol_syn
SNM1
resolver
genesymbol_syn
SNM1A
resolver
hgnc
HGNC:17660
resolver
uniprot
D3DRC1
resolver
uniprot
Q14701
resolver
uniprot
Q6P5Y3
resolver
uniprot
Q6PKL4
resolver
uniprot_entry
DCR1A_HUMAN
resolver
uniprot_sec
D3DRC1
resolver
uniprot_sec
Q14701
resolver
uniprot_sec
Q6P5Y3
resolver
uniprot_sec
Q6PKL4
resolver
activity_regulation
ACTIVITY REGULATION: Beta-lactamase activity is inhibited by sulbactam. {ECO:0000269|PubMed:31434986}.
uniprot
proteins
amino_acid_sequence
MLEDISEEDIWEYKSKRKPKRVDPNNGSKNILKSVEKATDGKYQSKRSRNRKRAAEAKEVKDHEVPLGNAGCQTSVASSQNSSCGDGIQQTQDKETTPGKLCRTQKSQHVSPKIRPVYDGYCPNCQMPFSSLIGQTPRWHVFECLDSPPRSETECPDGLLCTSTIPFHYKRYTHFLLAQSRAGDHPFSSPSPASGGSFSETKSGVLCSLEERWSSYQNQTDNSVSNDPLLMTQYFKKSPSLTEASEKISTHIQTSQQALQFTDFVENDKLVGVALRLANNSEHINLPLPENDFSDCEISYSPLQSDEDTHDIDEKPDDSQEQLFFTESSKDGSLEEDDDSCGFFKKRHGPLLKDQDESCPKVNSFLTRDKYDEGLYRFNSLNDLSQPISQNNESTLPYDLACTGGDFVLFPPALAGKLAASVHQATKAKPDEPEFHSAQSNKQKQVIEESSVYNQVSLPLVKSLMLKPFESQVEGYLSSQPTQNTIRKLSSENLNAKNNTNSACFCRKALEGVPVGKATILNTENLSSTPAPKYLKILPSGLKYNARHPSTKVMKQMDIGVYFGLPPKRKEEKLLGESALEGINLNPVPSPNQKRSSQCKRKAEKSLSDLEFDASTLHESQLSVELSSERSQRQKKRCRKSNSLQEGACQKRSDHLINTESEAVNLSKVKVFTKSAHGGLQRGNKKIPESSNVGGSRKKTCPFYKKIPGTGFTVDAFQYGVVEGCTAYFLTHFHSDHYAGLSKHFTFPVYCSEITGNLLKNKLHVQEQYIHPLPLDTECIVNGVKVVLLDANHCPGAVMILFYLPNGTVILHTGDFRADPSMERSLLADQKVHMLYLDTTYCSPEYTFPSQQEVIRFAINTAFEAVTLNPHALVVCGTYSIGKEKVFLAIADVLGSKVGMSQEKYKTLQCLNIPEINSLITTDMCSSLVHLLPMMQINFKGLQSHLKKCGGKYNQILAFRPTGWTHSNKFTRIADVIPQTKGNISIYGIPYSEHSSYLEMKRFVQWLKPQKIIPTVNVGTWKSRSTMEKYFREWKLEAGY
uniprot
proteins
ec_number
3.5.2.6
uniprot
proteins
function
FUNCTION: May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (PubMed:31434986). Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (PubMed:31434986). {ECO:0000269|PubMed:15542852}.
uniprot
proteins
mass_dalton
116400
uniprot
proteins
mutagenesis
MUTAGEN 838; /note="D->N: Impaired nuclear focus formation, reduced interaction with PIAS and increased sensitivity to cisplatin."; /evidence="ECO:0000269|PubMed:15572677"; MUTAGEN 994; /note="H->A: Impaired nuclear focus formation, reduced interaction with PIAS and increased sensitivity to cisplatin."; /evidence="ECO:0000269|PubMed:15572677
uniprot
proteins
protein_family
DNA repair metallo-beta-lactamase (DRMBL) family
uniprot
proteins
pubmed
10848582
uniprot
proteins
pubmed
12446782
uniprot
proteins
pubmed
12509242
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15542852
uniprot
proteins
pubmed
15572677
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
31434986
uniprot
proteins
pubmed
7788527
uniprot
proteins
sequence_length
1040
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10848582, ECO:0000269|PubMed:12446782, ECO:0000269|PubMed:15572677}. Note=In some cells it may be found in typically 1 or 2 discrete nuclear aggregates of unknown function which also contain TP53BP1. Also found in multiple discrete nuclear foci which increase in number following treatment with ionizing radiation or interstrand cross-linking agents. These foci overlap with those formed by the MRN complex (composed of MRE11, RAD50 and NBN) and BRCA1.
uniprot
proteins