TAS1R2
entrez
80834
canonical
uniprot
Q8TE23
canonical
ensembl
ENSG00000179002
resolver
ensp
ENSP00000364520
resolver
enst
ENST00000375371
resolver
genesymbol
TAS1R2
resolver
genesymbol_syn
GPR71
resolver
genesymbol_syn
T1R2
resolver
genesymbol_syn
TR2
resolver
hgnc
HGNC:14905
resolver
uniprot
Q5TZ19
resolver
uniprot_entry
TS1R2_HUMAN
resolver
uniprot_sec
Q5TZ19
resolver
amino_acid_sequence
MGPRAKTISSLFFLLWVLAEPAENSDFYLPGDYLLGGLFSLHANMKGIVHLNFLQVPMCKEYEVKVIGYNLMQAMRFAVEEINNDSSLLPGVLLGYEIVDVCYISNNVQPVLYFLAHEDNLLPIQEDYSNYISRVVAVIGPDNSESVMTVANFLSLFLLPQITYSAISDELRDKVRFPALLRTTPSADHHIEAMVQLMLHFRWNWIIVLVSSDTYGRDNGQLLGERVARRDICIAFQETLPTLQPNQNMTSEERQRLVTIVDKLQQSTARVVVVFSPDLTLYHFFNEVLRQNFTGAVWIASESWAIDPVLHNLTELRHLGTFLGITIQSVPIPGFSEFREWGPQAGPPPLSRTSQSYTCNQECDNCLNATLSFNTILRLSGERVVYSVYSAVYAVAHALHSLLGCDKSTCTKRVVYPWQLLEEIWKVNFTLLDHQIFFDPQGDVALHLEIVQWQWDRSQNPFQSVASYYPLQRQLKNIQDISWHTINNTIPMSMCSKRCQSGQKKKPVGIHVCCFECIDCLPGTFLNHTEDEYECQACPNNEWSYQSETSCFKRQLVFLEWHEAPTIAVALLAALGFLSTLAILVIFWRHFQTPIVRSAGGPMCFLMLTLLLVAYMVVPVYVGPPKVSTCLCRQALFPLCFTICISCIAVRSFQIVCAFKMASRFPRAYSYWVRYQGPYVSMAFITVLKMVIVVIGMLATGLSPTTRTDPDDPKITIVSCNPNYRNSLLFNTSLDLLLSVVGFSFAYMGKELPTNYNEAKFITLSMTFYFTSSVSLCTFMSAYSGVLVTIVDLLVTVLNLLAISLGYFGPKCYMILFYPERNTPAYFNSMIQGYTMRRD
uniprot
proteins
function
FUNCTION: Key component of the sweet taste receptor (PubMed:11917125, PubMed:40339580, PubMed:40754567, PubMed:40555359). TAS1R2 and TAS1R3 form the sweet taste receptor and recognize diverse natural and synthetic sweeteners (PubMed:11917125, PubMed:40339580, PubMed:40754567, PubMed:40555359). The sweet taste receptor has lower affinity for natural sugars than for synthetic sweeteners (PubMed:40339580, PubMed:40555359). Functions as a G protein-coupled receptor and primarily signals through the gustducin heterotrimer (PubMed:40339580). {ECO:0000269|PubMed:11917125, ECO:0000269|PubMed:40339580, ECO:0000269|PubMed:40555359, ECO:0000269|PubMed:40754567}.
uniprot
proteins
mass_dalton
95183
uniprot
proteins
mutagenesis
MUTAGEN 49; /note="V->A,R: Impairs receptor response to advantame. Abolishes receptor response to advantame; when associated with A-51 and A-159."; /evidence="ECO:0000269|PubMed:40754567"; MUTAGEN 51; /note="L->A,R: Impairs receptor response to advantame. Abolishes receptor response to advantame; when associated with A-49 and A-159."; /evidence="ECO:0000269|PubMed:40754567"; MUTAGEN 71; /note="L->F: Impairs receptor response to sucralose."; /evidence="ECO:0000269|PubMed:40555359"; MUTAGEN 103; /note="Y->A: Impairs receptor response to sucrose, sucralose and aspartame."; /evidence="ECO:0000269|PubMed:40339580, ECO:0000269|PubMed:40555359"; MUTAGEN 142; /note="D->A: Impairs receptor response to sucrose, sucralose and aspartame."; /evidence="ECO:0000269|PubMed:40339580, ECO:0000269|PubMed:40555359"; MUTAGEN 143; /note="N->A: Impairs receptor response to sucrose and aspartame; no effect on receptor response to sucralose."; /evidence="ECO:0000269|PubMed:40339580"; MUTAGEN 159; /note="L->A: Impairs receptor response to advantame. Abolishes receptor response to advantame; when associated with A-49 and A-51."; /evidence="ECO:0000269|PubMed:40754567"; MUTAGEN 165; /note="S->A: Impairs receptor response to sucrose, sucralose and aspartame."; /evidence="ECO:0000269|PubMed:40339580"; MUTAGEN 215; /note="Y->A: Impairs receptor response to sucrose, sucralose and aspartame."; /evidence="ECO:0000269|PubMed:40339580"; MUTAGEN 278; /note="D->A: Impairs receptor response to sucrose, sucralose and aspartame."; /evidence="ECO:0000269|PubMed:40339580"; MUTAGEN 302; /note="E->A: Impairs receptor response to sucralose."; /evidence="ECO:0000269|PubMed:40555359"; MUTAGEN 303; /note="S->A: Impairs receptor response to sucralose."; /evidence="ECO:0000269|PubMed:40555359"; MUTAGEN 598; /note="S->A: Impairs receptor response to sucralose."; /evidence="ECO:0000269|PubMed:40555359"; MUTAGEN 659; /note="F->A: Impairs receptor response to sucralose."; /evidence="ECO:0000269|PubMed:40555359"; MUTAGEN 669; /note="Y->A: Impairs receptor response to sucralose."; /evidence="ECO:0000269|PubMed:40555359"; MUTAGEN 756; /note="Y->A: Impairs receptor response to sucralose."; /evidence="ECO:0000269|PubMed:40555359"; MUTAGEN 831; /note="I->A: Impairs receptor response to sucralose."; /evidence="ECO:0000269|PubMed:40555359
uniprot
proteins
protein_family
G protein-coupled receptor 3 family
uniprot
proteins
protein_family
TAS1R subfamily
uniprot
proteins
pubmed
11917125
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
40339580
uniprot
proteins
pubmed
40555359
uniprot
proteins
pubmed
40754567
uniprot
proteins
sequence_length
839
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:40339580, ECO:0000269|PubMed:40555359, ECO:0000269|PubMed:40754567}; Multi-pass membrane protein {ECO:0000269|PubMed:40339580, ECO:0000269|PubMed:40555359, ECO:0000269|PubMed:40754567}.
uniprot
proteins
transmembrane_region
TRANSMEM 567..587; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:40339580, ECO:0000269|PubMed:40555359, ECO:0000269|PubMed:40754567, ECO:0000312|PDB:9UT8, ECO:0007744|PDB:9NOR, ECO:0007744|PDB:9OPY"; TRANSMEM 603..623; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:40339580, ECO:0000269|PubMed:40555359, ECO:0000269|PubMed:40754567, ECO:0000312|PDB:9UT8, ECO:0007744|PDB:9NOR, ECO:0007744|PDB:9OPY"; TRANSMEM 636..656; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:40339580, ECO:0000269|PubMed:40555359, ECO:0000269|PubMed:40754567, ECO:0000312|PDB:9UT8, ECO:0007744|PDB:9NOR, ECO:0007744|PDB:9OPY"; TRANSMEM 682..702; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:40339580, ECO:0000269|PubMed:40555359, ECO:0000269|PubMed:40754567, ECO:0000312|PDB:9UT8, ECO:0007744|PDB:9NOR, ECO:0007744|PDB:9OPY"; TRANSMEM 728..748; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:40339580, ECO:0000269|PubMed:40555359, ECO:0000269|PubMed:40754567, ECO:0000312|PDB:9UT8, ECO:0007744|PDB:9NOR, ECO:0007744|PDB:9OPY"; TRANSMEM 761..781; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:40339580, ECO:0000269|PubMed:40555359, ECO:0000269|PubMed:40754567, ECO:0000312|PDB:9UT8, ECO:0007744|PDB:9NOR, ECO:0007744|PDB:9OPY"; TRANSMEM 785..810; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:40339580, ECO:0000269|PubMed:40555359, ECO:0000269|PubMed:40754567, ECO:0000312|PDB:9UT8, ECO:0007744|PDB:9NOR, ECO:0007744|PDB:9OPY
uniprot
proteins