ALKAL2
entrez
285016
canonical
uniprot
Q6UX46
canonical
ensembl
ENSG00000189292
resolver
ensp
ENSP00000384604
resolver
ensp
ENSP00000389939
resolver
ensp
ENSP00000566992
resolver
ensp
ENSP00000566994
resolver
enst
ENST00000452023
resolver
genesymbol
ALKAL2
resolver
genesymbol_syn
FAM150B
resolver
hgnc
HGNC:27683
resolver
uniprot
A0A0B4J1W8
resolver
uniprot
B5MC76
resolver
uniprot_entry
A0A0B4J1W8_HUMAN
resolver
uniprot_entry
ALKL2_HUMAN
resolver
uniprot_sec
B5MC76
resolver
amino_acid_sequence
MRGPGHPLLLGLLLVLGAAGRGRGGAEPREPADGQALLRLVVELVQELRKHHSAEHKGLQLLGRDCALGRAEAAGLGPSPEQRVEIVPRDLRMKDKFLKHLTGPLYFSPKCSKHFHRLYHNTRDCTIPAYYKRCARLLTRLAVSPVCMEDKQ
uniprot
proteins
function
FUNCTION: Cytokine that acts as a physiological ligand for receptor tyrosine kinases LTK and ALK, leading to their activation (PubMed:26418745, PubMed:26630010, PubMed:30061385, PubMed:33411331, PubMed:34646012, PubMed:34819673). Cytokine-binding is sufficient to activate LTK (PubMed:34646012). In contrast, ALKAL2-driven activation of ALK is coupled with heparin-binding to ALK (PubMed:34646012). Stimulation of ALK signaling is involved in neural development and regulation of energy expenditure (PubMed:34646012, PubMed:34819673). {ECO:0000269|PubMed:26418745, ECO:0000269|PubMed:26630010, ECO:0000269|PubMed:30061385, ECO:0000269|PubMed:33411331, ECO:0000269|PubMed:34646012, ECO:0000269|PubMed:34819673}.
uniprot
proteins
mass_dalton
16915
uniprot
proteins
mutagenesis
MUTAGEN 66; /note="C->Y: Abolished interchain disulfide bond without affecting homodimerization."; /evidence="ECO:0000269|PubMed:34819673"; MUTAGEN 94..100; /note="KDKFLKH->EDEFLEE: Abolished association with the cell membrane, leading to impaired activation of receptor tyrosine kinase ALK."; /evidence="ECO:0000269|PubMed:34819673"; MUTAGEN 97; /note="F->E: Slightly reduced affinity for receptor tyrosine kinase LTK."; /evidence="ECO:0000269|PubMed:34646012"; MUTAGEN 100; /note="H->E: Slightly reduced affinity for receptor tyrosine kinase LTK."; /evidence="ECO:0000269|PubMed:34646012"; MUTAGEN 123; /note="R->E: Reduced affinity for receptor tyrosine kinases ALK and LTK."; /evidence="ECO:0000269|PubMed:34646012"; MUTAGEN 136; /note="R->E: Reduced affinity for receptor tyrosine kinases ALK and LTK."; /evidence="ECO:0000269|PubMed:34646012
uniprot
proteins
protein_family
ALKAL family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
25331893
uniprot
proteins
pubmed
26418745
uniprot
proteins
pubmed
26630010
uniprot
proteins
pubmed
30061385
uniprot
proteins
pubmed
33411331
uniprot
proteins
pubmed
34646012
uniprot
proteins
pubmed
34819673
uniprot
proteins
sequence_length
152
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:30061385}. Cell membrane {ECO:0000269|PubMed:34819673}. Note=Following interaction with receptor tyrosine kinase ALK, associates with the cell membrane, membrane-binding is required to activate ALK. {ECO:0000269|PubMed:34819673}.
uniprot
proteins