P2rx4
entrez
29659
canonical
uniprot
P51577
canonical
ensembl
ENSRNOG00000001300
resolver
ensembl
ENSRNOG00055014564
resolver
ensembl
ENSRNOG00060001911
resolver
ensembl
ENSRNOG00065006722
resolver
ensp
ENSRNOP00000001752
resolver
ensp
ENSRNOP00000102850
resolver
ensp
ENSRNOP00055020465
resolver
ensp
ENSRNOP00060001967
resolver
ensp
ENSRNOP00065007698
resolver
enst
ENSRNOT00000001752
resolver
enst
ENSRNOT00000152277
resolver
enst
ENSRNOT00055025035
resolver
enst
ENSRNOT00060002980
resolver
enst
ENSRNOT00065010473
resolver
genesymbol
P2rx4
resolver
uniprot
A0ABK0LIR9
resolver
uniprot_entry
A0ABK0LIR9_RAT
resolver
uniprot_entry
P2RX4_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by ATP (PubMed:28332633, PubMed:8622997). pH-dependent and inhibited by acidic pH (PubMed:24817123). {ECO:0000250|UniProtKB:Q99571, ECO:0000269|PubMed:24817123, ECO:0000269|PubMed:28332633, ECO:0000269|PubMed:8622997}.
uniprot
proteins
amino_acid_sequence
MAGCCSVLGSFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSVVSSVTTKAKGVAVTNTSQLGFRIWDVADYVIPAQEENSLFIMTNMIVTVNQTQSTCPEIPDKTSICNSDADCTPGSVDTHSSGVATGRCVPFNESVKTCEVAAWCPVENDVGVPTPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTSYLKSCIYNAQTDPFCPIFRLGTIVEDAGHSFQEMAVEGGIMGIQIKWDCNLDRAASLCLPRYSFRRLDTRDLEHNVSPGYNFRFAKYYRDLAGKEQRTLTKAYGIRFDIIVFGKAGKFDIIPTMINVGSGLALLGVATVLCDVIVLYCMKKKYYYRDKKYKYVEDYEQGLSGEMNQ
uniprot
proteins
function
FUNCTION: ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium. CTP, but not GTP or UTP, functions as a weak affinity agonist for P2RX4 (PubMed:28332633, PubMed:8622997). Activated by extracellularly released ATP, it plays multiple role in immunity and central nervous system physiology (PubMed:15985462, PubMed:24762105). Plays a key role in initial steps of T-cell activation and Ca(2+) microdomain formation (By similarity). Also participates in basal T-cell activity without TCR/CD3 stimulation (By similarity). Promotes the differentiation and activation of Th17 cells via expression of retinoic acid-related orphan receptor C/RORC (By similarity). Upon activation, drives microglia motility via the PI3K/Akt pathway (PubMed:12917686). Could also function as an ATP-gated cation channel of lysosomal membranes (PubMed:24817123). {ECO:0000250|UniProtKB:Q99571, ECO:0000250|UniProtKB:Q9JJX6, ECO:0000269|PubMed:12917686, ECO:0000269|PubMed:15985462, ECO:0000269|PubMed:24762105, ECO:0000269|PubMed:24817123, ECO:0000269|PubMed:28332633, ECO:0000269|PubMed:8598206, ECO:0000269|PubMed:8622997}.
uniprot
proteins
mass_dalton
43501
uniprot
proteins
mutagenesis
MUTAGEN 67; /note="K->A: Decreased cation transport."; /evidence="ECO:0000269|PubMed:24817123"; MUTAGEN 140; /note="H->A: Exhibits about 2.5-fold reduced ATP affinity and 14-fold reduced CTP affinity."; /evidence="ECO:0000269|PubMed:28332633"; MUTAGEN 140; /note="H->R: Exhibits about 2-fold reduced both ATP affinity and CTP affinity."; /evidence="ECO:0000269|PubMed:28332633"; MUTAGEN 186; /note="T->A,V: Abolishes ATP- and CTP-evoked current."; /evidence="ECO:0000269|PubMed:28332633"; MUTAGEN 186; /note="T->S: Does not affect ATP- and CTP-evoked current. Reduced ATP affinity. Does not affect CTP affinity."; /evidence="ECO:0000269|PubMed:28332633"; MUTAGEN 214; /note="L->A: Markedly reduced sensitivity to ATP."; /evidence="ECO:0000269|PubMed:24762105"; MUTAGEN 249; /note="E->K: Restores antagonism by PPADS."; /evidence="ECO:0000269|PubMed:8598206"; MUTAGEN 341; /note="S->W: Decreased cation transport."; /evidence="ECO:0000269|PubMed:24817123"; MUTAGEN 372; /note="Y->A: Complete loss of receptor functionality."; /evidence="ECO:0000269|PubMed:15985462
uniprot
proteins
protein_family
P2X receptor family
uniprot
proteins
pubmed
12077178
uniprot
proteins
pubmed
12917686
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15686495
uniprot
proteins
pubmed
15985462
uniprot
proteins
pubmed
24762105
uniprot
proteins
pubmed
24817123
uniprot
proteins
pubmed
25662851
uniprot
proteins
pubmed
28332633
uniprot
proteins
pubmed
7498461
uniprot
proteins
pubmed
8551329
uniprot
proteins
pubmed
8598206
uniprot
proteins
pubmed
8602843
uniprot
proteins
pubmed
8622997
uniprot
proteins
sequence_length
388
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15985462}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F8W463}. Lysosome membrane {ECO:0000269|PubMed:24817123}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..54; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:F8W463"; TRANSMEM 339..359; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:F8W463
uniprot
proteins