SLCO1B3
entrez
28234
canonical
uniprot
Q9NPD5
canonical
ensembl
ENSG00000111700
resolver
ensembl
ENSG00000257046
resolver
ensp
ENSP00000370956
resolver
genesymbol
SLCO1B3
resolver
genesymbol_syn
LST2
resolver
genesymbol_syn
OATP1B3
resolver
genesymbol_syn
OATP8
resolver
genesymbol_syn
SLC21A8
resolver
hgnc
HGNC:10961
resolver
uniprot
B3KP78
resolver
uniprot
E7EMT8
resolver
uniprot
Q5JAR4
resolver
uniprot_entry
B3KP78_HUMAN
resolver
uniprot_entry
SO1B3_HUMAN
resolver
uniprot_sec
E7EMT8
resolver
uniprot_sec
Q5JAR4
resolver
amino_acid_sequence
MDQHQHLNKTAESASSEKKKTRRCNGFKMFLAALSFSYIAKALGGIIMKISITQIERRFDISSSLAGLIDGSFEIGNLLVIVFVSYFGSKLHRPKLIGIGCLLMGTGSILTSLPHFFMGYYRYSKETHINPSENSTSSLSTCLINQTLSFNGTSPEIVEKDCVKESGSHMWIYVFMGNMLRGIGETPIVPLGISYIDDFAKEGHSSLYLGSLNAIGMIGPVIGFALGSLFAKMYVDIGYVDLSTIRITPKDSRWVGAWWLGFLVSGLFSIISSIPFFFLPKNPNKPQKERKISLSLHVLKTNDDRNQTANLTNQGKNVTKNVTGFFQSLKSILTNPLYVIFLLLTLLQVSSFIGSFTYVFKYMEQQYGQSASHANFLLGIITIPTVATGMFLGGFIIKKFKLSLVGIAKFSFLTSMISFLFQLLYFPLICESKSVAGLTLTYDGNNSVASHVDVPLSYCNSECNCDESQWEPVCGNNGITYLSPCLAGCKSSSGIKKHTVFYNCSCVEVTGLQNRNYSAHLGECPRDNTCTRKFFIYVAIQVINSLFSATGGTTFILLTVKIVQPELKALAMGFQSMVIRTLGGILAPIYFGALIDKTCMKWSTNSCGAQGACRIYNSVFFGRVYLGLSIALRFPALVLYIVFIFAMKKKFQGKDTKASDNERKVMDEANLEFLNNGEHFVPSAGTDSKTCNLDMQDNAAAN
uniprot
proteins
disease_involvement
DISEASE: Hyperbilirubinemia, Rotor type (HBLRR) [MIM:237450]: An autosomal recessive form of primary conjugated hyperbilirubinemia. Affected individuals develop mild jaundice not associated with hemolysis shortly after birth or in childhood. They have delayed plasma clearance of the unconjugated anionic dye bromsulphthalein and prominent urinary excretion of coproporphyrin I. Hepatic pigmentation is normal. {ECO:0000269|PubMed:22232210}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Mediates the Na(+)-independent uptake of organic anions (PubMed:10779507, PubMed:15159445, PubMed:17412826). Shows broad substrate specificity, can transport both organic anions such as bile acid taurocholate (cholyltaurine) and conjugated steroids (17-beta-glucuronosyl estradiol, dehydroepiandrosterone sulfate (DHEAS), and estrone 3-sulfate), as well as eicosanoid leukotriene C4, prostaglandin E2 and L-thyroxine (T4) (PubMed:10779507, PubMed:11159893, PubMed:12568656, PubMed:15159445, PubMed:17412826, PubMed:19129463). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (PubMed:19129463). Shows a pH-sensitive substrate specificity towards sulfated steroids, taurocholate and T4 which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:19129463). Involved in the clearance of bile acids and organic anions from the liver (PubMed:22232210). Can take up bilirubin glucuronides from plasma into the liver, contributing to the detoxification-enhancing liver-blood shuttling loop (PubMed:22232210). Transports coproporphyrin I and III, by-products of heme synthesis, and may be involved in their hepatic disposition (PubMed:26383540). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can transport HMG-CoA reductase inhibitors (also known as statins) such as pitavastatin, a clinically important class of hypolipidemic drugs (PubMed:15159445). May play an important role in plasma and tissue distribution of the structurally diverse chemotherapeutic drugs methotrexate and paclitaxel (PubMed:23243220). May also transport antihypertension agents, such as the angiotensin-converting enzyme (ACE) inhibitor prodrug enalapril, and the highly selective angiotensin II AT1-receptor antagonist valsartan, in the liver (PubMed:16624871, PubMed:16627748). {ECO:0000269|PubMed:10779507, ECO:0000269|PubMed:11159893, ECO:0000269|PubMed:12568656, ECO:0000269|PubMed:15159445, ECO:0000269|PubMed:16624871, ECO:0000269|PubMed:16627748, ECO:0000269|PubMed:17412826, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:22232210, ECO:0000269|PubMed:23243220, ECO:0000269|PubMed:26383540, ECO:0000305|PubMed:35307651}.
uniprot
proteins
mass_dalton
77403
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:10779507}.
uniprot
proteins
protein_family
Organo anion transporter (TC 2.A.60) family
uniprot
proteins
pubmed
10779507
uniprot
proteins
pubmed
11159893
uniprot
proteins
pubmed
11375950
uniprot
proteins
pubmed
12409283
uniprot
proteins
pubmed
12568656
uniprot
proteins
pubmed
15159445
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
16624871
uniprot
proteins
pubmed
16627748
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17412826
uniprot
proteins
pubmed
19129463
uniprot
proteins
pubmed
22232210
uniprot
proteins
pubmed
23243220
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26383540
uniprot
proteins
pubmed
35307651
uniprot
proteins
sequence_length
702
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:10779507}; Multi-pass membrane protein {ECO:0000305}. Basal cell membrane {ECO:0000269|PubMed:35307651}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the basolateral membrane of hepatocytes (PubMed:10779507). Localized to the basal membrane of Sertoli cells (PubMed:35307651). {ECO:0000269|PubMed:10779507, ECO:0000269|PubMed:35307651}.
uniprot
proteins
transmembrane_region
TRANSMEM 29..48; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 68..88; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 95..119; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 169..197; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 217..237; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 256..280; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 332..353; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 374..397; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 402..425; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 538..560; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 570..595; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 630..647; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins