APH1B
entrez
83464
canonical
uniprot
Q8WW43
canonical
ensembl
ENSG00000138613
resolver
ensp
ENSP00000261879
resolver
ensp
ENSP00000369700
resolver
ensp
ENSP00000453002
resolver
genesymbol
APH1B
resolver
genesymbol_syn
PSFL
resolver
hgnc
HGNC:24080
resolver
uniprot
A8K589
resolver
uniprot
Q564N3
resolver
uniprot
Q6UWQ1
resolver
uniprot
Q9H0S0
resolver
uniprot_entry
APH1B_HUMAN
resolver
uniprot_sec
A8K589
resolver
uniprot_sec
Q564N3
resolver
uniprot_sec
Q6UWQ1
resolver
uniprot_sec
Q9H0S0
resolver
amino_acid_sequence
MTAAVFFGCAFIAFGPALALYVFTIATEPLRIIFLIAGAFFWLVSLLISSLVWFMARVIIDNKDGPTQKYLLIFGAFVSVYIQEMFRFAYYKLLKKASEGLKSINPGETAPSMRLLAYVSGLGFGIMSGVFSFVNTLSDSLGPGTVGIHGDSPQFFLYSAFMTLVIILLHVFWGIVFFDGCEKKKWGILLIVLLTHLLVSAQTFISSYYGINLASAFIILVLMGTWAFLAAGGSCRSLKLCLLCQDKNFLLYNQRSR
uniprot
proteins
function
FUNCTION: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A. {ECO:0000269|PubMed:12297508}.
uniprot
proteins
mass_dalton
28460
uniprot
proteins
protein_family
APH-1 family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12297508
uniprot
proteins
pubmed
12740439
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15823552
uniprot
proteins
pubmed
16572171
uniprot
proteins
sequence_length
257
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..25; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 32..52; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 71..91; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 115..135; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 158..178; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 186..206; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 213..233; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins