LZTS1
entrez
11178
canonical
uniprot
Q9Y250
canonical
ensembl
ENSG00000061337
resolver
ensp
ENSP00000265801
resolver
ensp
ENSP00000370981
resolver
genesymbol
LZTS1
resolver
genesymbol_syn
FEZ1
resolver
hgnc
HGNC:13861
resolver
uniprot
D3DSQ6
resolver
uniprot
Q9Y5V7
resolver
uniprot
Q9Y5V8
resolver
uniprot
Q9Y5V9
resolver
uniprot
Q9Y5W0
resolver
uniprot
Q9Y5W1
resolver
uniprot
Q9Y5W2
resolver
uniprot_entry
LZTS1_HUMAN
resolver
uniprot_sec
D3DSQ6
resolver
uniprot_sec
Q9Y5V7
resolver
uniprot_sec
Q9Y5V8
resolver
uniprot_sec
Q9Y5V9
resolver
uniprot_sec
Q9Y5W0
resolver
uniprot_sec
Q9Y5W1
resolver
uniprot_sec
Q9Y5W2
resolver
amino_acid_sequence
MGSVSSLISGHSFHSKHCRASQYKLRKSSHLKKLNRYSDGLLRFGFSQDSGHGKSSSKMGKSEDFFYIKVSQKARGSHHPDYTALSSGDLGGQAGVDFDPSTPPKLMPFSNQLEMGSEKGAVRPTAFKPVLPRSGAILHSSPESASHQLHPAPPDKPKEQELKPGLCSGALSDSGRNSMSSLPTHSTSSSYQLDPLVTPVGPTSRFGGSAHNITQGIVLQDSNMMSLKALSFSDGGSKLGHSNKADKGPSCVRSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPKGGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTSFGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELRTQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPTFPEDVPALQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVIQYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPLEVDLEGADIPYEDIIATEI
uniprot
proteins
disease_involvement
DISEASE: Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. {ECO:0000269|PubMed:10097140}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as a tumor suppressor. {ECO:0000269|PubMed:10097140, ECO:0000269|PubMed:11464283, ECO:0000269|PubMed:11504921}.
uniprot
proteins
mass_dalton
66613
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine residues. Hyperphosphorylated by the cAMP-dependent kinase PKA during cell-cycle progression.; PTM: Ubiquitinated by the ECS(ASB7) complex, leading to its degradation. {ECO:0000269|PubMed:39039081}.
uniprot
proteins
protein_family
LZTS family
uniprot
proteins
pubmed
10097140
uniprot
proteins
pubmed
11464283
uniprot
proteins
pubmed
11504921
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16484223
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
39039081
uniprot
proteins
sequence_length
596
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Postsynaptic density {ECO:0000250}. Synapse {ECO:0000250}. Note=Associated with the plasma membrane and with microtubules. Detected in dendritic spines, especially in the postsynaptic density (By similarity). {ECO:0000250}.
uniprot
proteins