HACD2
entrez
201562
canonical
uniprot
Q6Y1H2
canonical
ensembl
ENSG00000206527
resolver
ensp
ENSP00000373153
resolver
ensp
ENSP00000648657
resolver
enst
ENST00000383657
resolver
genesymbol
HACD2
resolver
genesymbol_syn
PTPLB
resolver
hgnc
HGNC:9640
resolver
uniprot_entry
HACD2_HUMAN
resolver
amino_acid_sequence
MAAVAATAAAKGNGGGGGRAGAGDASGTRKKKGPGPLATAYLVIYNVVMTAGWLVIAVGLVRAYLAKGSYHSLYYSIEKPLKFFQTGALLEILHCAIGIVPSSVVLTSFQVMSRVFLIWAVTHSVKEVQSEDSVLLFVIAWTITEIIRYSFYTFSLLNHLPYLIKWARYTLFIVLYPMGVSGELLTIYAALPFVRQAGLYSISLPNKYNFSFDYYAFLILIMISYIPIFPQLYFHMIHQRRKILSHTEEHKKFE
uniprot
proteins
ec_number
4.2.1.134
uniprot
proteins
function
FUNCTION: Catalyzes the third of the very long-chain fatty acids (VLCFA) elongation four-step cycle (condensation, reduction, dehydration, and reduction). This endoplasmic reticulum-elongation process is characterized by the addition of two carbons to the lipid chain through each cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of elongation. Therefore, it participates in the production of various VLCFAs involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000269|PubMed:18554506}.
uniprot
proteins
mass_dalton
28368
uniprot
proteins
mutagenesis
MUTAGEN 101; /note="P->R: Does not restore any protein tyrosine phosphatase activity."; /evidence="ECO:0000269|PubMed:15024066
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000269|PubMed:18554506}.
uniprot
proteins
protein_family
Very long-chain fatty acids dehydratase HACD family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15024066
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
18554506
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25732826
uniprot
proteins
pubmed
38422897
uniprot
proteins
sequence_length
254
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15024066, ECO:0000269|PubMed:18554506}; Multi-pass membrane protein {ECO:0000269|PubMed:15024066, ECO:0000269|PubMed:18554506}.
uniprot
proteins
transmembrane_region
TRANSMEM 42..60; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 80..97; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 108..125; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 131..146; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 170..187; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 218..235; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins