Phf7
entrez
364510
canonical
uniprot
Q6AXW4
canonical
ensembl
ENSRNOG00000018996
resolver
ensembl
ENSRNOG00055022687
resolver
ensembl
ENSRNOG00060012349
resolver
ensembl
ENSRNOG00065014481
resolver
ensp
ENSRNOP00000040832
resolver
ensp
ENSRNOP00000079388
resolver
ensp
ENSRNOP00055031605
resolver
ensp
ENSRNOP00060016519
resolver
ensp
ENSRNOP00065018631
resolver
enst
ENSRNOT00000044991
resolver
enst
ENSRNOT00000107128
resolver
enst
ENSRNOT00055038930
resolver
enst
ENSRNOT00060020944
resolver
enst
ENSRNOT00065023927
resolver
genesymbol
PHD finger protein 7
resolver
genesymbol
Phf7
resolver
uniprot
A0A8L2QKI0
resolver
uniprot_entry
A0A8L2QKI0_RAT
resolver
uniprot_entry
PHF7_RAT
resolver
amino_acid_sequence
MRTIKEKKEHPRLRKTARTKKVTHRKLSSGPVCLLCFQEPGDPEKLGEFLQKDNLCVHYFCLILSSKLPQKGQPNRGLHGFMPEDIKKEAARASRKVCFVCKRKGAAIRCQKDQCVQNFHLPCGQERGCLSQFFGEYKSYCGKHRPTQNIHQRSFGESCVLCCEDLSRASVENIRSPCCSQAIYHRKCIQKYAHTSAKHFFKCPQCNNREEFPQEMLRMGIHIPDRDAAWELEPGAFSELYQRYQHCDAPICLYEQGRDSFEDEGRWRLILCATCGSHGTHRDCSSLRPNSKKWECNECLPASTEDSVSENLGDTPCCSSTFCPHEPFLRATSLEENPGSSWTNWLQPSLLEKPESSSGSSCQSWRSKGIKVTKDCKKSK
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase which ubiquitinates histone H3 at 'Lys-14' (By similarity). Required for male fertility, via inhibition of SPOP-mediated BRDT degradation when in the presence of acetylated histone H4 in early condensing spermatids (By similarity). Stabilization of BRDT allows it to facilitate histone removal in early condensing spermatids and promote the progression of histone-to-protamine exchange (By similarity). Promotes the expression of steroidogenesis proteins in the testes, and as a result plays a role in maintaining testosterone levels and repressing osteoclastogenesis (By similarity). Promotes transcription of cardiac enhancer genes by facilitating binding of cardiac transcription factors such as MEF2C and GATA4 to target gene promoters (By similarity). Ubiquitinates histone H4 (By similarity). Ubiquitinates histone H2A and H3 as part of the nucleosome core particle (By similarity). {ECO:0000250|UniProtKB:Q9BWX1, ECO:0000250|UniProtKB:Q9DAG9}.
uniprot
proteins
mass_dalton
43388
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9DAG9}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
380
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BWX1}.
uniprot
proteins