Pabir1
entrez
68034
canonical
uniprot
Q9DB52
canonical
ensembl
ENSMUSG00000074922
resolver
ensp
ENSMUSP00000097152
resolver
enst
ENSMUST00000099556
resolver
genesymbol
Pabir1
resolver
genesymbol_syn
Fam122a
resolver
uniprot
Q3TA50
resolver
uniprot
Q9D078
resolver
uniprot_entry
PBIR1_MOUSE
resolver
uniprot_sec
Q3TA50
resolver
uniprot_sec
Q9D078
resolver
amino_acid_sequence
MAQEKMELDLELPAGASPAEGGGPGGGGLRRSNSAPLIHGLSDSSPVFQAEAPSARRNSTTFPSRHGLLLPASPVRMHSSRLHQIKQEEGMDLINRETVHEREVQTAMQISHSWEESFSLSDNDVEKSASPKRIDFIPVSPAPSPTRGIGKQCFSPSLQSFVSSNGLPPSPIPSPTTRFTTRRSQSPINCIRPSVLGPLKRKCEMETDYQPKRFFQGITNMLSSDVAQLSDPGVCVSSDTLDGNSSSAGSSCNSPAKVSTTTDSPVSPAQAASPFIPVDELSSK
uniprot
proteins
function
FUNCTION: Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity (By similarity). Inhibits PP2A activity by blocking the substrate binding site on PPP2R2A and the active site of PPP2CA (By similarity). Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) (By similarity). Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby releasing G2/M checkpoint (By similarity). {ECO:0000250|UniProtKB:Q96E09}.
uniprot
proteins
mass_dalton
30270
uniprot
proteins
post_translational_modification
PTM: CHEK1-mediated phosphorylation at Ser-34 negatively regulates its ability to inhibit serine/threonine-protein phosphatase 2A (PP2A) activity. Phosphorylation leads to its release from the PP2A complex and its sequestration by 14-3-3 proteins in the cytoplasm resulting in its inability to translocate to the nucleus, where it otherwise inhibits PP2A. {ECO:0000250|UniProtKB:Q96E09}.
uniprot
proteins
protein_family
FAM122 family
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
284
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96E09}. Cytoplasm {ECO:0000250|UniProtKB:Q96E09}. Note=The CHEK1-mediated Ser-34 phosphorylated form is sequestered by 14-3-3 proteins in the cytoplasm and fails to translocate to the nucleus, where it otherwise inhibits serine/threonine-protein phosphatase 2A. {ECO:0000250|UniProtKB:Q96E09}.
uniprot
proteins