Gnl3l
entrez
237107
canonical
uniprot
Q6PGG6
canonical
ensembl
ENSMUSG00000025266
resolver
ensp
ENSMUSP00000026297
resolver
ensp
ENSMUSP00000108311
resolver
enst
ENSMUST00000026297
resolver
enst
ENSMUST00000112691
resolver
genesymbol
Gnl3l
resolver
uniprot_entry
GNL3L_MOUSE
resolver
amino_acid_sequence
MMKIRHKNKKPGKGSKGCKKPARQNGKKVTSRPSSAPQIVHGNDHASREAELKKKRVEEMREKQQVAREQERQRHRTMESYCQDVLKRQQEFEQKEEVLQELNMFPQLDDEATRKAYYKEFRKVVEYSDVILEVLDARDPLGCRCFQMEETVLRAEGNKKLVLVLNKIDLVPKEIVEKWLEYLLNELPTVAFKASTQHHQVKNLTRCKVPVDQASESLLKSRACFGAENLMRVLGNYCRLGEVRGHIRVGVVGLPNVGKSSLINSLKRSRACSVGAVPGVTKFMQEVYLDKFIRLLDAPGIVPGPNSEVGTILRNCIHVQKLADPVTPVETILQRCNLEEISSYYGVSGFQTTEHFLTAVAHRLGKKKKGGVYSQEQAAKAVLADWVSGKISFYTLPPPTHTLPTHLSAEIVKEMTEVFDIEDTEHANEDTMECLAVGESDELLGDMDPQEMEVRWLHSPLVKIADAIENRSTVYKIGNLTGYCTKPNRNQMGWPKRNVDHHCPQNNRVVEVSSVDRRPMLQRILETDPLQQGQALASALKNKKKLQKRSDKIATKLSDSMMSMLDLSGNSDDCAGD
uniprot
proteins
function
FUNCTION: Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP (By similarity). {ECO:0000250, ECO:0000269|PubMed:19487455, ECO:0000269|PubMed:21132010}.
uniprot
proteins
mass_dalton
65195
uniprot
proteins
mutagenesis
MUTAGEN 166; /note="N->I: No effect on TERF1-binding. Loss of ability to stabilize TERF1 protein."; /evidence="ECO:0000269|PubMed:19487455"; MUTAGEN 253; /note="G->V: Mislocalized to the nucleoplasm. No effect on the reduction of MDM2 ubiquitination."; /evidence="ECO:0000269|PubMed:21132010
uniprot
proteins
protein_family
TRAFAC class YlqF/YawG GTPase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19487455
uniprot
proteins
pubmed
21132010
uniprot
proteins
sequence_length
577
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:21132010}.
uniprot
proteins