P2rx5
entrez
113995
canonical
uniprot
P51578
canonical
ensembl
ENSRNOG00000019208
resolver
ensp
ENSRNOP00000026156
resolver
ensp
ENSRNOP00000111027
resolver
enst
ENSRNOT00000026156
resolver
enst
ENSRNOT00000126428
resolver
genesymbol
P2rx5
resolver
uniprot
A0ABK0M6R6
resolver
uniprot
A6HGI1
resolver
uniprot
G3V8I0
resolver
uniprot
Q64613
resolver
uniprot_entry
A0ABK0M6R6_RAT
resolver
uniprot_entry
P2RX5_RAT
resolver
uniprot_sec
A6HGI1
resolver
uniprot_sec
G3V8I0
resolver
uniprot_sec
Q64613
resolver
activity_regulation
ACTIVITY REGULATION: Activated by ATP (PubMed:8690069, PubMed:8786426). Slowly desensitizing (PubMed:8786426). Not activated by ATP agonist alpha/beta-methylene-ATP (PubMed:8690069, PubMed:8786426). Highly sensitive to the antagonists suramin and PPADS (PubMed:8690069, PubMed:8786426). {ECO:0000269|PubMed:8690069, ECO:0000269|PubMed:8786426}.
uniprot
proteins
amino_acid_sequence
MGQAAWKGFVLSLFDYKTAKFVVAKSKKVGLLYRVLQLIILLYLLIWVFLIKKSYQDIDTSLQSAVVTKVKGVAYTNTTMLGERLWDVADFVIPSQGENVFFVVTNLIVTPNQRQGICAEREGIPDGECSEDDDCHAGESVVAGHGLKTGRCLRVGNSTRGTCEIFAWCPVETKSMPTDPLLKDAESFTIFIKNFIRFPKFNFSKANVLETDNKHFLKTCHFSSTNLYCPIFRLGSIVRWAGADFQDIALKGGVIGIYIEWDCDLDKAASKCNPHYYFNRLDNKHTHSISSGYNFRFARYYRDPNGVEFRDLMKAYGIRFDVIVNGKAGKFSIIPTVINIGSGLALMGAGAFFCDLVLIYLIRKSEFYRDKKFEKVRGQKEDANVEVEANEMEQERPEDEPLERVRQDEQSQELAQSGRKQNSNCQVLLEPARFGLRENAIVNVKQSQILHPVKT
uniprot
proteins
function
FUNCTION: ATP-gated nonselective transmembrane cation channel (PubMed:8786426). Permeable to potassium, sodium and calcium (By similarity). Unlike other P2RX receptors, the P2X5 receptor is also permeable to chloride (By similarity). Acts as an important regulator of inflammatory-related bone loss and osteoclast multinucleation (By similarity). {ECO:0000250|UniProtKB:Q91VE2, ECO:0000250|UniProtKB:Q93086, ECO:0000269|PubMed:8786426}.
uniprot
proteins
mass_dalton
51539
uniprot
proteins
mutagenesis
MUTAGEN 67; /note="V->I: Increases the ATP-evoked response."; /evidence="ECO:0000269|PubMed:31727741"; MUTAGEN 195; /note="F->H: Increases the ATP-evoked response."; /evidence="ECO:0000269|PubMed:31727741
uniprot
proteins
protein_family
P2X receptor family
uniprot
proteins
pubmed
10336430
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
17001079
uniprot
proteins
pubmed
31727741
uniprot
proteins
pubmed
8690069
uniprot
proteins
pubmed
8786426
uniprot
proteins
pubmed
9855626
uniprot
proteins
sequence_length
455
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q93086}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P56373}.
uniprot
proteins
transmembrane_region
TRANSMEM 35..55; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:F8W463"; TRANSMEM 342..362; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P56373
uniprot
proteins