MTMR8
entrez
55613
canonical
uniprot
Q96EF0
canonical
ensembl
ENSG00000102043
resolver
ensp
ENSP00000363985
resolver
genesymbol
MTMR8
resolver
hgnc
HGNC:16825
resolver
uniprot
Q5JT99
resolver
uniprot
Q9NXP6
resolver
uniprot_entry
MTMR8_HUMAN
resolver
uniprot_sec
Q5JT99
resolver
uniprot_sec
Q9NXP6
resolver
activity_regulation
ACTIVITY REGULATION: Interaction with MTMR9 increases phosphatase activity. {ECO:0000269|PubMed:22647598}.
uniprot
proteins
amino_acid_sequence
MDHITVPKVENVKLVDRYVSKKPANGILYLTATHLIYVEASGAARKETWIALHHIATVEKLPITSLGCPLTLRCKNFRVAHFVLDSDLVCHEVYISLLKLSQPALPEDLYAFSYNPKSSKEMRESGWKLIDPISDFGRMGIPNRNWTITDANRNYEICSTYPPEIVVPKSVTLGTVVGSSKFRSKERVPVLSYLYKENNAAICRCSQPLSGFYTRCVDDELLLEAISQTNPGSQFMYVVDTRPKLNAMANRAAGKGYENEDNYANIRFRFMGIENIHVMRSSLQKLLEVCELKTPTMSEFLSGLESSGWLRHIKAIMDAGIFITKAVKVEKASVLVHCSDGWDRTAQVCSVASILLDPFYRTFKGLMILIEKEWISMGHKFSQRCGHLDGDSKEVSPIFTQFLDCIWQLMEQFPCAFEFNENFLLEIHDHVFSCQFGNFLGNCQKDREDLRVYEKTHSVWPFLVQRKPDFRNPLYKGFTMYGVLNPSTVPYNIQFWCGMYNRFDKGLQPKQSMLESLLEIKKQRAMLETDVHELEKKLKVRDEPPEEICTCSQLGNILSQHLGSPLTNPLGFMGINGDLNTLMENGTLSREGGLRAQMDQVKSQGADLHHNCCEIVGSLRAINISGDVGISEAMGISGDMCTFEATGFSKDLGICGAMDISEATGISGNLGISEARGFSGDMGILGDTGISKASTKEADYSKHQ
uniprot
proteins
ec_number
3.1.3.95
uniprot
proteins
function
FUNCTION: Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:22647598, PubMed:26143924). In complex with MTMR9, negatively regulates autophagy (PubMed:22647598). {ECO:0000269|PubMed:22647598, ECO:0000269|PubMed:26143924}.
uniprot
proteins
mass_dalton
78919
uniprot
proteins
mutagenesis
MUTAGEN 253; /note="A->K: Increased phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity."; /evidence="ECO:0000269|PubMed:26143924"; MUTAGEN 255; /note="K->A: Decreased phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity."; /evidence="ECO:0000269|PubMed:26143924
uniprot
proteins
protein_family
Non-receptor class myotubularin subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
16787938
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
22647598
uniprot
proteins
pubmed
26143924
uniprot
proteins
sequence_length
704
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000269|PubMed:16787938}.
uniprot
proteins