Asb3
entrez
65257
canonical
uniprot
Q9WV72
canonical
ensembl
ENSMUSG00000020305
resolver
ensp
ENSMUSP00000020551
resolver
ensp
ENSMUSP00000242878
resolver
enst
ENSMUST00000020551
resolver
genesymbol
Asb3
resolver
uniprot
Q5SSV5
resolver
uniprot_entry
ASB3_MOUSE
resolver
uniprot_sec
Q5SSV5
resolver
amino_acid_sequence
MDFTEAYSDTCSTVGLAAREGNVKILRKLLKKGRSVDVADNRGWMPIHEAAYHNAVECLQMLIHTDSSENYIKAKTFEGFCALHLAVSQGHWKITQILLEAGADPNETTLEETTPLFLAVESGRIDVLKLLLQHGANVNGSHSMSGWNSLHQASFQGNAETIRLLLKQGADRECQDDFGITPLFVAAQYGKLESMSILISSGANVNCQALDKATPLFIAAQEGHTKCVELLLSSGADPDLYCNEDNWQLPIHAAAQMGHTETLDLLIPRTNRACDTGPDKVSPVYSAVFGGREECLEMLLQNGYSPDAQMCLVFGFSSPLCMAFQKDCDFSGIVNILLKYGAQLNELHLAYCLKYEKFSMFCSFLKKGSLMVPWNHTSEFISYAVKAQTKYKAWLPHLLLAGFDPLILLCSSSWVDSASDDILIFTLEFSNWKRLPSAVEKMLSVRANSSWALQQHLASVPSLTHLCRLEIRASLKAEHLHSDIFIHQLPLPRSLQNYLLYEEVLRMNEILEPAANQDGETSKAT
uniprot
proteins
function
FUNCTION: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes TNFRSF1B. Plays a role in the down-regulation of antiviral innate immunity by targeting MAVS for ubiquitin-proteasomal degradation. Also destabilizes TRAF6 by enhancing its 'Lys-48'-linked polyubiquitination. {ECO:0000250|UniProtKB:Q9Y575, ECO:0000269|PubMed:39162488, ECO:0000269|PubMed:39266719}.
uniprot
proteins
mass_dalton
58283
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
Ankyrin SOCS box (ASB) family
uniprot
proteins
pubmed
11111040
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
39162488
uniprot
proteins
pubmed
39266719
uniprot
proteins
sequence_length
525
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Y575}.
uniprot
proteins