Osbpl5
entrez
79196
canonical
uniprot
Q9ER64
canonical
ensembl
ENSMUSG00000037606
resolver
ensp
ENSMUSP00000020411
resolver
ensp
ENSMUSP00000113362
resolver
ensp
ENSMUSP00000318604
resolver
enst
ENSMUST00000020411
resolver
enst
ENSMUST00000119499
resolver
genesymbol
Osbpl5
resolver
genesymbol_syn
Obph1
resolver
genesymbol_syn
Osbp2
resolver
uniprot
G5E833
resolver
uniprot
Q8R510
resolver
uniprot
Q99NF5
resolver
uniprot_entry
G5E833_MOUSE
resolver
uniprot_entry
OSBL5_MOUSE
resolver
uniprot_sec
Q8R510
resolver
uniprot_sec
Q99NF5
resolver
amino_acid_sequence
MKEEAFLRRRFSLCPPASTPQKTDPRKVPRNLLLGCENELGPITPGRDMESNGPSQPRDEEPQTPGSATKVPLAEYRLCNGSDKECTSPTTRVSKKDALKAQKENYRQEKKRATKQLFSALTDPSVVIMADSLKIRGTLKSWTKLWCVLKPGVLLIYKTPKVGQWVGTVLLHCCELIERPSKKDGFCFKLFHPLDQSVWAVKGPKGESVGSITQPLPSSYLIFRAASESDGRCWLDALELALRCSSLLRLSTCKQGRDGEQGSSPDASPSSLYGLPTSATIPDQDLFPLNGSALENDAFSDKSERENAEDSDAETQDHSRKTNESGSDLLDSPGGPWRGTTYVEQVQEELGELDETSQVETVSEENKSLMWVLLRQLRPGMDLSRVVLPTFVLEPRSFLGKLSDYYYHGDLLSRAAAEDDPYCRMKLVLRWYLSGFYKKPKGIKKPYNPILGETFRCRWLHPQTNSHTFYIAEQVSHHPPVSAFYVSNRKDGFCMSGSITAKSKFYGNSLSALLDGKAKLTFLNRKEEYTLTMPYAHCRGILYGTMTMELGGKVNIECEKNNLQAELDFKLKPFFGSSANINQISGKIMSGEEVLARLTGHWDRDVFIKEESSGGTELFWTPSEEVRRQRLKRHTVLLEEQSELESERLWQHVTRAIREGDQHKATQEKSVLEEAQRQRAREHQQSLTPWKPQLFLLDPLTQEWRYRYEDLSPWDPLKDIAQYEQDGILHTLQRETMSGQTTFLGSPDSRHKRPSSDRRLRKASDQPSGHSQVTESSGSTPESCPDLSDEDFVPGGESPCPRCRREVHRLKMLQEAVLSIQEAQQELHRHLSTMLSSTVRAGQAPAPSLLQNPRSWFLLCIFLTCQLFINYILK
uniprot
proteins
function
FUNCTION: Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes. Binds 25-hydroxycholesterol and cholesterol. {ECO:0000250|UniProtKB:Q9H0X9}.
uniprot
proteins
mass_dalton
98922
uniprot
proteins
protein_family
OSBP family
uniprot
proteins
pubmed
11063728
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18024232
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
874
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9H0X9}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9H0X9}. Note=Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS). Localizes to the cortical endoplasmic reticulum at the EPCS. {ECO:0000250|UniProtKB:Q9H0X9}.
uniprot
proteins
transmembrane_region
TRANSMEM 855..873; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins