Foxn4
entrez
116810
canonical
uniprot
Q8K3Q3
canonical
ensembl
ENSMUSG00000042002
resolver
ensp
ENSMUSP00000047951
resolver
enst
ENSMUST00000044790
resolver
genesymbol
Foxn4
resolver
uniprot
Q0VGP0
resolver
uniprot
Q920C0
resolver
uniprot_entry
FOXN4_MOUSE
resolver
uniprot_sec
Q0VGP0
resolver
uniprot_sec
Q920C0
resolver
amino_acid_sequence
MIESGIWSRMSEMIRSSGHSHHCSPQEYRFLPPVGDDDLPGDLQSLSWLTAVDVPRLQQMANGRIDLGSSGVTHPHPGALAGTADLHVGAAPRPLLRRSQTAVVPRGVLGLSPIGNHRASAEQMNQFPAGGQASSGLQEMPQLYSPATQIPFPLPLGSQQCPPAGLYGSPFSARPSYPQAHGAMHASQEPHPKHYPKPIYSYSCLIAMALKNSKTGSLPVSEIYSFMKEHFPYFKTAPDGWKNSVRHNLSLNKCFEKVETKSSGSSRKGCLWALNLARIDKMEEEMHKWKRKDLAAIHRSMANPEELDKLISDRPESCRRPGKRGEPKAPMLTHATTVAMAHSCLAISQLPPKPLMTLSLQSVPLHHQLQPQAHLAPDSPAPAQTPPLHALPSLSPGPLPQPAMGRVPGDFLNINSDMNTEVDALDPSIMDFALQGNLWEEMKEDSFSLDTLEAFGDSPLGCDLGAPSLTPVSGNSDQSFPDVQVTGLYAAYSTAADGVAPSAANSAQYLGTPGNKPIALL
uniprot
proteins
function
FUNCTION: Transcription factor essential for neural and some non-neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4-NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development. {ECO:0000269|PubMed:15363391, ECO:0000269|PubMed:16020526, ECO:0000269|PubMed:17728344, ECO:0000269|PubMed:21438071, ECO:0000269|PubMed:22323600, ECO:0000269|PubMed:23652001}.
uniprot
proteins
mass_dalton
56121
uniprot
proteins
pubmed
11520680
uniprot
proteins
pubmed
15363391
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16020526
uniprot
proteins
pubmed
17728344
uniprot
proteins
pubmed
21438071
uniprot
proteins
pubmed
22323600
uniprot
proteins
pubmed
23652001
uniprot
proteins
sequence_length
521
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:22323600}.
uniprot
proteins