Pecam1
entrez
29583
canonical
uniprot
Q3SWT0
canonical
ensembl
ENSRNOG00000066008
resolver
ensp
ENSRNOP00000086124
resolver
ensp
ENSRNOP00000088286
resolver
ensp
ENSRNOP00000088919
resolver
ensp
ENSRNOP00000091045
resolver
ensp
ENSRNOP00000093793
resolver
enst
ENSRNOT00000105483
resolver
enst
ENSRNOT00000106375
resolver
enst
ENSRNOT00000110556
resolver
enst
ENSRNOT00000110646
resolver
enst
ENSRNOT00000117538
resolver
genesymbol
Pecam1
resolver
genesymbol_syn
Pecam
resolver
uniprot
A0A8I6A5G8
resolver
uniprot
A0A8I6A674
resolver
uniprot
A0A8I6ADR9
resolver
uniprot
A0A8I6AKA0
resolver
uniprot
A0A8I6GHL3
resolver
uniprot
P97635
resolver
uniprot_entry
A0A8I6A5G8_RAT
resolver
uniprot_entry
A0A8I6A674_RAT
resolver
uniprot_entry
A0A8I6ADR9_RAT
resolver
uniprot_entry
A0A8I6AKA0_RAT
resolver
uniprot_entry
A0A8I6GHL3_RAT
resolver
uniprot_entry
PECA1_RAT
resolver
uniprot_sec
P97635
resolver
amino_acid_sequence
MLLALLLTMLLYASLQAQENSFTINSIHMESRPSWEVSNGQKLTLQCLVDISTTSKSRPQHQVLFYKDDALVYNVSSSEHTESFVIPQSRVFHAGKYKCTVILNSKEKTTIEYQLTVNGVPMPEVTVDKKEVTEGGIVTVNCSMQEEKPPIYFKIEKVELGTKNVKLSREKTSNMNFVLIEFPIEEQDHLLVFRCQAGVLSGIKMQTSEFIRSEYVTVQEFFSTPKFQIQPPEMIIEGNQLHIKCSVQVAHLAQEFPEIIIQKDKAIVATSKQSKEAVYSVMALVEHSGHYTCKVESNRISKASSILVNITELFPRPKLELSSSRLDQGEMLDLSCSVSGAPVANFTIQKEETVLSQYQNFSKIAEERDSGLYSCTAGIGKVVKRSNLVPVQVCEMLSKPRIFHDAKFEIIKGQIIGISCQSVNGTAPITYRLLRAKSNFQTVQKNSNDPVTFTDKPTRDMEYQCIVDNCHSHPEVRSEILRVKVIAPVDEVTISILSGNDVQSGDEMVLRCSVKEGTGPVTFQFYKEKEGRPFHEETVNDTQVFWHHEQTSKEQEGQYYCTAFNRASIVTSLRSGPLTVRVFLAPWKKGLIAVVVIGVVIAALIVAAKYYFLRKAKAKQKPVEMSRPAVPLLNSNSEKVSEPSVETNSHYDSQNMDVEYTEVEVSSLEPHQENGRLP
uniprot
proteins
function
FUNCTION: Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-660 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils. Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal. Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes. Modulates bradykinin receptor BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells. Induces susceptibility to atherosclerosis. {ECO:0000250|UniProtKB:P16284, ECO:0000250|UniProtKB:Q08481}.
uniprot
proteins
mass_dalton
76189
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser and Tyr residues after cellular activation. In endothelial cells Fyn mediates mechanical-force (stretch or pull) induced tyrosine phosphorylation. Phosphorylated on tyrosine residues by FER and FES in response to FCER1 activation. {ECO:0000250|UniProtKB:P16284, ECO:0000250|UniProtKB:Q08481}.; PTM: Palmitoylation by ZDHHC21 is necessary for cell surface expression in endothelial cells and enrichment in membrane rafts. {ECO:0000250|UniProtKB:P16284}.
uniprot
proteins
pubmed
10878616
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
678
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P16284}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P16284}. Membrane raft {ECO:0000250|UniProtKB:P16284}. Cell junction {ECO:0000250|UniProtKB:P16284}. Note=Localizes to the lateral border recycling compartment (LBRC) and recycles from the LBRC to the junction in resting endothelial cells. Cell surface expression on neutrophils is down-regulated upon fMLP or CXCL8/IL8-mediated stimulation. {ECO:0000250|UniProtKB:P16284}.
uniprot
proteins
transmembrane_region
TRANSMEM 590..610; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins