SLC13A1
entrez
6561
canonical
uniprot
Q9BZW2
canonical
ensembl
ENSG00000081800
resolver
ensp
ENSP00000194130
resolver
enst
ENST00000194130
resolver
genesymbol
SLC13A1
resolver
genesymbol_syn
NAS1
resolver
genesymbol_syn
NASI1
resolver
hgnc
HGNC:10916
resolver
uniprot
A4D0X1
resolver
uniprot
Q2NKK0
resolver
uniprot
Q9H5Z0
resolver
uniprot_entry
A4D0X1_HUMAN
resolver
uniprot_entry
Q2NKK0_HUMAN
resolver
uniprot_entry
S13A1_HUMAN
resolver
uniprot_sec
Q9H5Z0
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by thiosulfate, selenate, molybdate, tungstate, citrate and succinate. {ECO:0000269|PubMed:11161786}.
uniprot
proteins
amino_acid_sequence
MKFFSYILVYRRFLFVVFTVLVLLPLPIVLHTKEAECAYTLFVVATFWLTEALPLSVTALLPSLMLPMFGIMPSKKVASAYFKDFHLLLIGVICLATSIEKWNLHKRIALKMVMMVGVNPAWLTLGFMSSTAFLSMWLSNTSTAAMVMPIAEAVVQQIINAEAEVEATQMTYFNGSTNHGLEIDESVNGHEINERKEKTKPVPGYNNDTGKISSKVELEKNSGMRTKYRTKKGHVTRKLTCLCIAYSSTIGGLTTITGTSTNLIFAEYFNTRYPDCRCLNFGSWFTFSFPAALIILLLSWIWLQWLFLGFNFKEMFKCGKTKTVQQKACAEVIKQEYQKLGPIRYQEIVTLVLFIIMALLWFSRDPGFVPGWSALFSEYPGFATDSTVALLIGLLFFLIPAKTLTKTTPTGEIVAFDYSPLITWKEFQSFMPWDIAILVGGGFALADGCEESGLSKWIGNKLSPLGSLPAWLIILISSLMVTSLTEVASNPATITLFLPILSPLAEAIHVNPLYILIPSTLCTSFAFLLPVANPPNAIVFSYGHLKVIDMVKAGLGVNIVGVAVVMLGICTWIVPMFDLYTYPSWAPAMSNETMP
uniprot
proteins
function
FUNCTION: Sodium:sulfate symporter that mediates sulfate reabsorption in the kidney and small intestine (PubMed:11161786, PubMed:38552027, PubMed:39576865). Can also mediate the transport of selenate and thiosulfate (By similarity). {ECO:0000250|UniProtKB:Q07782, ECO:0000269|PubMed:11161786, ECO:0000269|PubMed:38552027, ECO:0000269|PubMed:39576865}.
uniprot
proteins
mass_dalton
66134
uniprot
proteins
mutagenesis
MUTAGEN 135; /note="S->A: Abolished sodium:sulfate symporter activity."; /evidence="ECO:0000269|PubMed:39576865"; MUTAGEN 139; /note="S->A: Abolished sodium:sulfate symporter activity."; /evidence="ECO:0000269|PubMed:39576865"; MUTAGEN 140; /note="N->A: Abolished sodium:sulfate symporter activity."; /evidence="ECO:0000269|PubMed:39576865"; MUTAGEN 141; /note="T->A: Abolished sodium:sulfate symporter activity."; /evidence="ECO:0000269|PubMed:39576865"; MUTAGEN 260; /note="S->A: Abolished sodium:sulfate symporter activity."; /evidence="ECO:0000269|PubMed:39576865"; MUTAGEN 489; /note="S->A: Abolished sodium:sulfate symporter activity."; /evidence="ECO:0000269|PubMed:39576865"; MUTAGEN 490; /note="N->A: Abolished sodium:sulfate symporter activity."; /evidence="ECO:0000269|PubMed:39576865"; MUTAGEN 491; /note="P->A: Abolished sodium:sulfate symporter activity."; /evidence="ECO:0000269|PubMed:39576865
uniprot
proteins
protein_family
NADC subfamily
uniprot
proteins
protein_family
SLC13A/DASS transporter (TC 2.A.47) family
uniprot
proteins
pubmed
11161786
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
38552027
uniprot
proteins
pubmed
39576865
uniprot
proteins
sequence_length
595
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q07782}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..27; /note="Helical"; /evidence="ECO:0000269|PubMed:38552027, ECO:0000269|PubMed:39576865, ECO:0007744|PDB:8W6H, ECO:0007744|PDB:8W6N, ECO:0007744|PDB:8W6O, ECO:0007744|PDB:8Y5U, ECO:0007744|PDB:8Y5W"; TRANSMEM 39..52; /note="Helical"; /evidence="ECO:0000269|PubMed:38552027, ECO:0000269|PubMed:39576865, ECO:0007744|PDB:8W6H, ECO:0007744|PDB:8W6N, ECO:0007744|PDB:8W6O, ECO:0007744|PDB:8Y5U, ECO:0007744|PDB:8Y5W"; TRANSMEM 54..64; /note="Helical"; /evidence="ECO:0000269|PubMed:38552027, ECO:0000269|PubMed:39576865, ECO:0007744|PDB:8W6H, ECO:0007744|PDB:8W6N, ECO:0007744|PDB:8W6O, ECO:0007744|PDB:8Y5U, ECO:0007744|PDB:8Y5W"; TRANSMEM 82..98; /note="Helical"; /evidence="ECO:0000269|PubMed:38552027, ECO:0000269|PubMed:39576865, ECO:0007744|PDB:8W6H, ECO:0007744|PDB:8W6N, ECO:0007744|PDB:8W6O, ECO:0007744|PDB:8Y5U, ECO:0007744|PDB:8Y5W"; TRANSMEM 245..267; /note="Helical"; /evidence="ECO:0000269|PubMed:38552027, ECO:0000269|PubMed:39576865, ECO:0007744|PDB:8W6H, ECO:0007744|PDB:8W6N, ECO:0007744|PDB:8W6O, ECO:0007744|PDB:8Y5U, ECO:0007744|PDB:8Y5W"; TRANSMEM 279..302; /note="Helical"; /evidence="ECO:0000269|PubMed:38552027, ECO:0000269|PubMed:39576865, ECO:0007744|PDB:8W6H, ECO:0007744|PDB:8W6N, ECO:0007744|PDB:8W6O, ECO:0007744|PDB:8Y5U, ECO:0007744|PDB:8Y5W"; TRANSMEM 349..363; /note="Helical"; /evidence="ECO:0000269|PubMed:38552027, ECO:0000269|PubMed:39576865, ECO:0007744|PDB:8W6H, ECO:0007744|PDB:8W6N, ECO:0007744|PDB:8W6O, ECO:0007744|PDB:8Y5U, ECO:0007744|PDB:8Y5W"; TRANSMEM 383..399; /note="Helical"; /evidence="ECO:0000269|PubMed:38552027, ECO:0000269|PubMed:39576865, ECO:0007744|PDB:8W6H, ECO:0007744|PDB:8W6N, ECO:0007744|PDB:8W6O, ECO:0007744|PDB:8Y5U, ECO:0007744|PDB:8Y5W"; TRANSMEM 420..441; /note="Helical"; /evidence="ECO:0000269|PubMed:38552027, ECO:0000269|PubMed:39576865, ECO:0007744|PDB:8W6H, ECO:0007744|PDB:8W6N, ECO:0007744|PDB:8W6O, ECO:0007744|PDB:8Y5U, ECO:0007744|PDB:8Y5W"; TRANSMEM 517..536; /note="Helical"; /evidence="ECO:0000269|PubMed:38552027, ECO:0000269|PubMed:39576865, ECO:0007744|PDB:8W6H, ECO:0007744|PDB:8W6N, ECO:0007744|PDB:8W6O, ECO:0007744|PDB:8Y5U, ECO:0007744|PDB:8Y5W"; TRANSMEM 550..568; /note="Helical"; /evidence="ECO:0000269|PubMed:38552027, ECO:0000269|PubMed:39576865, ECO:0007744|PDB:8W6H, ECO:0007744|PDB:8W6N, ECO:0007744|PDB:8W6O, ECO:0007744|PDB:8Y5U, ECO:0007744|PDB:8Y5W
uniprot
proteins