Rnf13
entrez
24017
canonical
uniprot
O54965
canonical
ensembl
ENSMUSG00000036503
resolver
ensp
ENSMUSP00000049331
resolver
ensp
ENSMUSP00000142335
resolver
ensp
ENSMUSP00000142462
resolver
ensp
ENSMUSP00000143498
resolver
ensp
ENSMUSP00000160661
resolver
ensp
ENSMUSP00000160672
resolver
ensp
ENSMUSP00000160700
resolver
enst
ENSMUST00000198214
resolver
enst
ENSMUST00000200497
resolver
genesymbol
Rnf13
resolver
genesymbol_syn
Rzf
resolver
uniprot
A0A0G2JDQ7
resolver
uniprot
A0A0G2JGB3
resolver
uniprot
O54966
resolver
uniprot
Q3UTG4
resolver
uniprot
Q6PEA8
resolver
uniprot
Q8C4F9
resolver
uniprot
Q8CB78
resolver
uniprot_entry
A0A0G2JDQ7_MOUSE
resolver
uniprot_entry
A0A0G2JGB3_MOUSE
resolver
uniprot_entry
Q3UTG4_MOUSE
resolver
uniprot_entry
Q8C4F9_MOUSE
resolver
uniprot_entry
Q8CB78_MOUSE
resolver
uniprot_entry
RNF13_MOUSE
resolver
uniprot_sec
O54966
resolver
uniprot_sec
Q6PEA8
resolver
amino_acid_sequence
MLLSIGMLMLSATQVYTILTVQLFAFLNLLPVEADILAYNFENASQTFEDLPARFGYRLPAEGLKGFLINSKPENACEPIVPPPLKDNSSGTFIVLIRRLDCNFDIKVLNAQRAGYKAAIVHNVDSDDLISMGSNDIDTLKKIDIPSVFIGESSANSLKDEFTYEKGGHIILVPELSLPLEYYLIPFLIIVGICLILIVIFMITKFVQDRHRNRRNRLRKDQLKKLPVHKFKKGDEYDVCAICLEEYEDGDKLRILPCSHAYHCKCVDPWLTKTKKTCPVCKQKVVPSQGDSDSDTDSSQEENQVSEHTPLLPPSASARTQSFGSLSESHSHHNMTESSDYEDDDNEETDSSDADNEITDHSVVVQLQPNGEQDYNIANTV
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that regulates cell proliferation (PubMed:19292867). Involved in apoptosis regulation (By similarity). Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA (By similarity). Also involved in protein trafficking and localization (By similarity). {ECO:0000250|UniProtKB:O43567, ECO:0000269|PubMed:19292867}.
uniprot
proteins
mass_dalton
42732
uniprot
proteins
mutagenesis
MUTAGEN 266; /note="C->A: Loss of E3 ligase activity."; /evidence="ECO:0000269|PubMed:19292867
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:19292867}.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. {ECO:0000269|PubMed:19292867}.; PTM: N-glycosylated and also modified with chondroitin sulfate. {ECO:0000269|PubMed:19292867}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19292867
uniprot
proteins
pubmed
20230530
uniprot
proteins
sequence_length
381
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O43567}; Single-pass type I membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:19292867}; Single-pass type I membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:19292867}; Single-pass type I membrane protein {ECO:0000255}. Nucleus inner membrane {ECO:0000269|PubMed:20230530}; Single-pass type I membrane protein {ECO:0000255}. Note=The mature protein is subjected to extensive proteolysis that leads to the shedding of the ectodomain into the lumen of vesicles and the release of the C-terminal fragment into the cytosol (PubMed:20230530). Not detected in early endosomes (PubMed:20230530). Treatment of the cells with either PMA or ionomycin stabilizes the full-length protein which relocalizes to recycling endosomes and to the inner nuclear membrane (PubMed:20230530). {ECO:0000269|PubMed:20230530}.
uniprot
proteins
transmembrane_region
TRANSMEM 183..203; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins