CLNS1A
entrez
1207
canonical
uniprot
P54105
canonical
ensembl
ENSG00000074201
resolver
ensp
ENSP00000263309
resolver
ensp
ENSP00000433741
resolver
ensp
ENSP00000433919
resolver
ensp
ENSP00000434311
resolver
ensp
ENSP00000434963
resolver
ensp
ENSP00000548827
resolver
ensp
ENSP00000548828
resolver
ensp
ENSP00000548829
resolver
ensp
ENSP00000548830
resolver
ensp
ENSP00000595581
resolver
ensp
ENSP00000595582
resolver
ensp
ENSP00000595583
resolver
ensp
ENSP00000595586
resolver
ensp
ENSP00000595587
resolver
ensp
ENSP00000595589
resolver
ensp
ENSP00000626612
resolver
enst
ENST00000263309
resolver
enst
ENST00000525064
resolver
enst
ENST00000525428
resolver
enst
ENST00000528364
resolver
enst
ENST00000532069
resolver
enst
ENST00000878768
resolver
enst
ENST00000878769
resolver
enst
ENST00000878770
resolver
enst
ENST00000878771
resolver
enst
ENST00000925522
resolver
enst
ENST00000925523
resolver
enst
ENST00000925524
resolver
enst
ENST00000925527
resolver
enst
ENST00000925528
resolver
enst
ENST00000925530
resolver
enst
ENST00000956553
resolver
genesymbol
CLNS1A
resolver
genesymbol_syn
CLCI
resolver
genesymbol_syn
ICLN
resolver
hgnc
HGNC:2080
resolver
uniprot
B2RCS9
resolver
uniprot
E9PJF4
resolver
uniprot
E9PMI6
resolver
uniprot
J3KN38
resolver
uniprot
Q0VDK6
resolver
uniprot
Q9NRD2
resolver
uniprot
Q9NRD3
resolver
uniprot_entry
E9PJF4_HUMAN
resolver
uniprot_entry
E9PMI6_HUMAN
resolver
uniprot_entry
ICLN_HUMAN
resolver
uniprot_entry
J3KN38_HUMAN
resolver
uniprot_sec
B2RCS9
resolver
uniprot_sec
Q0VDK6
resolver
uniprot_sec
Q9NRD2
resolver
uniprot_sec
Q9NRD3
resolver
amino_acid_sequence
MSFLKSFPPPGPAEGLLRQQPDTEAVLNGKGLGTGTLYIAESRLSWLDGSGLGFSLEYPTISLHALSRDRSDCLGEHLYVMVNAKFEEESKEPVADEEEEDSDDDVEPITEFRFVPSDKSALEAMFTAMCECQALHPDPEDEDSDDYDGEEYDVEAHEQGQGDIPTFYTYEEGLSHLTAEGQATLERLEGMLSQSVSSQYNMAGVRTEDSIRDYEDGMEVDTTPTVAGQFEDADVDH
uniprot
proteins
function
FUNCTION: Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (PubMed:10330151, PubMed:11713266, PubMed:18984161, PubMed:21081503). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (PubMed:10330151, PubMed:18984161). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (PubMed:10330151). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (PubMed:10330151, PubMed:18984161). Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (PubMed:10330151, PubMed:18984161). {ECO:0000269|PubMed:10330151, ECO:0000269|PubMed:11713266, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21081503}.
uniprot
proteins
mass_dalton
26215
uniprot
proteins
protein_family
PICln (TC 1.A.47) family
uniprot
proteins
pubmed
10330151
uniprot
proteins
pubmed
10825435
uniprot
proteins
pubmed
11713266
uniprot
proteins
pubmed
11747828
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16087681
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17487921
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
18984161
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21081503
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
7887970
uniprot
proteins
pubmed
8579598
uniprot
proteins
pubmed
9359436
uniprot
proteins
sequence_length
237
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21081503}. Nucleus {ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:21081503}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18984161}. Note=A small fraction is also associated with the cytoskeleton (PubMed:18984161).
uniprot
proteins