Plp1
entrez
18823
canonical
uniprot
P60202
canonical
ensembl
ENSMUSG00000031425
resolver
ensp
ENSMUSP00000033800
resolver
ensp
ENSMUSP00000108708
resolver
ensp
ENSMUSP00000217872
resolver
ensp
ENSMUSP00000217873
resolver
genesymbol
Plp1
resolver
genesymbol_syn
Plp
resolver
uniprot
P04400
resolver
uniprot
P06905
resolver
uniprot
Q3UYM8
resolver
uniprot
Q9WUS9
resolver
uniprot_entry
MYPR_MOUSE
resolver
uniprot_entry
Q3UYM8_MOUSE
resolver
uniprot_sec
P04400
resolver
uniprot_sec
P06905
resolver
uniprot_sec
Q9WUS9
resolver
amino_acid_sequence
MGLLECCARCLVGAPFASLVATGLCFFGVALFCGCGHEALTGTEKLIETYFSKNYQDYEYLINVIHAFQYVIYGTASFFFLYGALLLAEGFYTTGAVRQIFGDYKTTICGKGLSATVTGGQKGRGSRGQHQAHSLERVCHCLGKWLGHPDKFVGITYALTVVWLLVFACSAVPVYIYFNTWTTCQSIAFPSKTSASIGSLCADARMYGVLPWNAFPGKVCGSNLLSICKTAEFQMTFHLFIAAFVGAAATLVSLLTFMIAATYNFAVLKLMGRGTKF
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Plp1 are the cause of the dysmyelinating diseases Jimpy and Rumpshaker (rsh).
uniprot
proteins
function
FUNCTION: This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.
uniprot
proteins
mass_dalton
30077
uniprot
proteins
protein_family
Myelin proteolipid protein family
uniprot
proteins
pubmed
1380672
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1688931
uniprot
proteins
pubmed
17634366
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2432393
uniprot
proteins
pubmed
2441390
uniprot
proteins
pubmed
2442307
uniprot
proteins
pubmed
2444462
uniprot
proteins
pubmed
2449535
uniprot
proteins
pubmed
2451027
uniprot
proteins
pubmed
3466187
uniprot
proteins
pubmed
3469678
uniprot
proteins
sequence_length
277
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17634366}; Multi-pass membrane protein {ECO:0000269|PubMed:17634366}. Myelin membrane {ECO:0000269|PubMed:17634366}. Note=Colocalizes with SIRT2 in internodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheat.
uniprot
proteins
transmembrane_region
TRANSMEM 10..36; /note="Helical; Name=1"; /evidence="ECO:0000305"; TRANSMEM 64..88; /note="Helical; Name=2"; /evidence="ECO:0000305"; TRANSMEM 152..177; /note="Helical; Name=3"; /evidence="ECO:0000305"; TRANSMEM 234..260; /note="Helical; Name=4"; /evidence="ECO:0000305
uniprot
proteins