Atcay
entrez
16467
canonical
uniprot
Q8BHE3
canonical
ensembl
ENSMUSG00000034958
resolver
ensp
ENSMUSP00000036721
resolver
enst
ENSMUST00000047408
resolver
genesymbol
Atcay
resolver
uniprot
Q3TR94
resolver
uniprot_entry
ATCAY_MOUSE
resolver
uniprot_sec
Q3TR94
resolver
amino_acid_sequence
MGTTEATLRMENVDVRDEWQDEDLPRPLPEDTGVERLGGAVEDSSSPPSTLNLSGAHRKRKTLVAPEINISLDQSEGSLLSDDFLDTPDDLDINVDDIETPDETDSLEFLGNGNELEWEDDTPVATAKNMPGDSADLFGDGSAEDGSAANGRLWRTVIIGEQEHRIDLHMIRPYMKVVTHGGYYGEGLNAIIVFAACFLPDSSSPDYHYIMENLFLYVISSLELLVAEDYMIVYLNGATPRRRMPGIGWLKKCYHMIDRRLRKNLKSLIIVHPSWFIRTVLAISRPFISVKFISKIQYVHSLEELERLIPMEHVQLPDCVLQYEEQRLRAKRESTRPPQPEFLLPRSEEKPETVEEEDRAAEATEDQETSMS
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Atcay are the cause of jittery phenotype, which is characterized by severe truncal and limb ataxia and death due to starvation and dehydration by 3-4 weeks of age. {ECO:0000269|PubMed:14556008}.
uniprot
proteins
function
FUNCTION: Functions in the development of neural tissues, particularly the postnatal maturation of the cerebellar cortex. May play a role in neurotransmission through regulation of glutaminase/GLS, an enzyme responsible for the production in neurons of the glutamate neurotransmitter. Alternatively, may regulate the localization of mitochondria within axons and dendrites. {ECO:0000269|PubMed:19861499}.
uniprot
proteins
mass_dalton
42178
uniprot
proteins
post_translational_modification
PTM: Cleaved by CASP3 and CASP7. The potential C-terminal product released by CASP3 cleavage may inhibit the ERK signaling pathway through MAP2K2. {ECO:0000269|PubMed:21369758}.; PTM: May be ubiquitinated by STUB1. {ECO:0000250}.
uniprot
proteins
pubmed
14556008
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16899818
uniprot
proteins
pubmed
17157273
uniprot
proteins
pubmed
19861499
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21369758
uniprot
proteins
sequence_length
372
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, axon {ECO:0000250|UniProtKB:Q1M168}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q1M168}. Presynapse {ECO:0000269|PubMed:17157273}. Mitochondrion {ECO:0000250|UniProtKB:Q1M168}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q1M168}. Cytoplasm {ECO:0000250|UniProtKB:Q86WG3}.
uniprot
proteins