Nme6
entrez
58964
canonical
uniprot
O88426
canonical
ensembl
ENSRNOG00000020721
resolver
ensembl
ENSRNOG00055007330
resolver
ensembl
ENSRNOG00060024362
resolver
ensembl
ENSRNOG00065007216
resolver
ensp
ENSRNOP00000028125
resolver
ensp
ENSRNOP00055009682
resolver
ensp
ENSRNOP00060034983
resolver
ensp
ENSRNOP00065008190
resolver
enst
ENSRNOT00055012211
resolver
enst
ENSRNOT00060042187
resolver
enst
ENSRNOT00065011221
resolver
genesymbol
Nme6
resolver
uniprot
R9PXW5
resolver
uniprot_entry
NDK6_RAT
resolver
uniprot_sec
R9PXW5
resolver
amino_acid_sequence
MTSILRSPQTLQLTLALIKPDAVAHPLILEAVHQQILSNKFLIVRMRELLWKPEDCRRFYREHEGRFFYQRLVEFMTSGPIRAYILAHKDAIQLWRTLMGPTRVFRARHIAPDSIRGSLGLTDTRNTTHGSDSVVSASREIAAFFPDFSEQRWYEEEEPQLRCGPVHYSPEEGIHCAAETGGPKPA
uniprot
proteins
ec_number
2.7.4.6
uniprot
proteins
function
FUNCTION: Catalytic subunit of a complex with RCC1L, which catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside diphosphate via a ping-pong mechanism involving the formation of a phosphohistidine intermediate. Participates in the regulation of mitochondrial nucleotide levels, mitoribosome biogenesis, and mitochondrial RNA abundances. Supplies pyrimidine ribonucleoside triphosphates (rNTPs) for mitochondrial transcription and is required for the maintenance of mitochondrial DNA (mtDNA) when the import of pyrimidine deoxyribonucleoside triphosphates (dNTPs) is limited from the cytosol is limited. As a monomer, lacks nucleoside diphosphate kinase (NDPK) activity. {ECO:0000250|UniProtKB:O75414}.
uniprot
proteins
mass_dalton
21340
uniprot
proteins
protein_family
NDK family
uniprot
proteins
pubmed
10453732
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
186
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:O75414}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:O75414}; Peripheral membrane protein {ECO:0000250|UniProtKB:O75414}. Mitochondrion {ECO:0000250|UniProtKB:O75414}. Note=Predominantly localized in mitochondrion matrix, however partially bound to mitochondrion inner membrane (MIM), peripherally bound and facing the matrix space. {ECO:0000250|UniProtKB:O75414}.
uniprot
proteins