Agrp
entrez
11604
canonical
uniprot
P56473
canonical
ensembl
ENSMUSG00000005705
resolver
ensp
ENSMUSP00000005849
resolver
ensp
ENSMUSP00000141783
resolver
ensp
ENSMUSP00000142044
resolver
enst
ENSMUST00000005849
resolver
enst
ENSMUST00000194091
resolver
genesymbol
Agrp
resolver
genesymbol_syn
Agrt
resolver
genesymbol_syn
Art
resolver
uniprot
O35967
resolver
uniprot
Q3UU47
resolver
uniprot_entry
AGRP_MOUSE
resolver
uniprot_entry
Q3UU47_MOUSE
resolver
uniprot_sec
O35967
resolver
amino_acid_sequence
MLTAMLLSCVLLLALPPTLGVQMGVAPLKGIRRPDQALFPEFPGLSLNGLKKTTADRAEEVLLQKAEALAEVLDPQNRESRSPRRCVRLHESCLGQQVPCCDPCATCYCRFFNAFCYCRKLGTATNLCSRT
uniprot
proteins
function
FUNCTION: Signaling protein that functions as an antagonist of melanocyte-stimulating-hormone receptors MC3R and MC4R by precluding agonist-induced signaling, thereby inhibiting cAMP production within the hypothalamus and adrenal gland (PubMed:9892020). Involved in the control of feeding behavior via the central melanocortin system (By similarity). Has very low activity towards MC5R (PubMed:9892020). Also promotes endocytosis of MC3R and MC4R in an arrestin-dependent mechanism (By similarity). {ECO:0000250|UniProtKB:O00253, ECO:0000269|PubMed:9892020}.
uniprot
proteins
mass_dalton
14432
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9119224
uniprot
proteins
pubmed
9311920
uniprot
proteins
pubmed
9892020
uniprot
proteins
sequence_length
131
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:O00253}. Golgi apparatus lumen {ECO:0000250|UniProtKB:O00253}.
uniprot
proteins