POLL
entrez
27343
canonical
uniprot
Q9UGP5
canonical
ensembl
ENSG00000166169
resolver
ensp
ENSP00000299206
resolver
ensp
ENSP00000343102
resolver
ensp
ENSP00000359181
resolver
ensp
ENSP00000359191
resolver
ensp
ENSP00000400676
resolver
ensp
ENSP00000485885
resolver
ensp
ENSP00000552415
resolver
ensp
ENSP00000552417
resolver
ensp
ENSP00000552419
resolver
ensp
ENSP00000552420
resolver
ensp
ENSP00000552422
resolver
ensp
ENSP00000552424
resolver
ensp
ENSP00000612821
resolver
ensp
ENSP00000705261
resolver
ensp
ENSP00000733281
resolver
enst
ENST00000370172
resolver
genesymbol
POLL
resolver
hgnc
HGNC:9184
resolver
uniprot
A8K860
resolver
uniprot
B4DE17
resolver
uniprot
D3DR76
resolver
uniprot
Q5JQP5
resolver
uniprot
Q5JQP8
resolver
uniprot
Q6NUM2
resolver
uniprot
Q9BTN8
resolver
uniprot
Q9HA10
resolver
uniprot
Q9HB35
resolver
uniprot_entry
A8K860_HUMAN
resolver
uniprot_entry
B4DE17_HUMAN
resolver
uniprot_entry
DPOLL_HUMAN
resolver
uniprot_entry
Q5JQP8_HUMAN
resolver
uniprot_sec
D3DR76
resolver
uniprot_sec
Q5JQP5
resolver
uniprot_sec
Q6NUM2
resolver
uniprot_sec
Q9BTN8
resolver
uniprot_sec
Q9HA10
resolver
uniprot_sec
Q9HB35
resolver
amino_acid_sequence
MDPRGILKAFPKRQKIHADASSKVLAKIPRREEGEEAEEWLSSLRAHVVRTGIGRARAELFEKQIVQHGGQLCPAQGPGVTHIVVDEGMDYERALRLLRLPQLPPGAQLVKSAWLSLCLQERRLVDVAGFSIFIPSRYLDHPQPSKAEQDASIPPGTHEALLQTALSPPPPPTRPVSPPQKAKEAPNTQAQPISDDEASDGEETQVSAADLEALISGHYPTSLEGDCEPSPAPAVLDKWVCAQPSSQKATNHNLHITEKLEVLAKAYSVQGDKWRALGYAKAINALKSFHKPVTSYQEACSIPGIGKRMAEKIIEILESGHLRKLDHISESVPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTTQQAIGLKHYSDFLERMPREEATEIEQTVQKAAQAFNSGLLCVACGSYRRGKATCGDVDVLITHPDGRSHRGIFSRLLDSLRQEGFLTDDLVSQEENGQQQKYLGVCRLPGPGRRHRRLDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSEHALSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYREPAERDW
uniprot
proteins
ec_number
2.7.7.7
uniprot
proteins
ec_number
4.2.99.-
uniprot
proteins
function
FUNCTION: DNA polymerase that functions in several pathways of DNA repair (PubMed:11457865, PubMed:19806195, PubMed:20693240, PubMed:30250067). Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA (PubMed:11457865, PubMed:19806195). Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination (PubMed:19806195, PubMed:20693240, PubMed:30250067). Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities (PubMed:10887191, PubMed:10982892, PubMed:12809503, PubMed:14627824, PubMed:15537631, PubMed:19806195). Also has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity (PubMed:11457865, PubMed:19806195). {ECO:0000269|PubMed:10887191, ECO:0000269|PubMed:10982892, ECO:0000269|PubMed:11457865, ECO:0000269|PubMed:12809503, ECO:0000269|PubMed:14627824, ECO:0000269|PubMed:15537631, ECO:0000269|PubMed:19806195, ECO:0000269|PubMed:20693240, ECO:0000269|PubMed:30250067}.
uniprot
proteins
mass_dalton
63482
uniprot
proteins
mutagenesis
MUTAGEN 312; /note="K->A: Reduces dRP lyase activity by over 90%."; /evidence="ECO:0000269|PubMed:11457865"; MUTAGEN 427; /note="D->A: Loss of polymerase activity; when associated with A-429."; /evidence="ECO:0000269|PubMed:19806195"; MUTAGEN 429; /note="D->A: Loss of polymerase activity; when associated with A-427."; /evidence="ECO:0000269|PubMed:19806195"; MUTAGEN 505; /note="Y->A: No effect on polymerase activity. Reduces terminal transferase activities."; /evidence="ECO:0000269|PubMed:14627824"; MUTAGEN 506; /note="F->G,R: Strongly reduces polymerase and terminal transferase activities."; /evidence="ECO:0000269|PubMed:14627824
uniprot
proteins
protein_family
DNA polymerase type-X family
uniprot
proteins
pubmed
10887191
uniprot
proteins
pubmed
10982892
uniprot
proteins
pubmed
11457865
uniprot
proteins
pubmed
12809503
uniprot
proteins
pubmed
12911298
uniprot
proteins
pubmed
14627824
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14992725
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15358682
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15537631
uniprot
proteins
pubmed
17475573
uniprot
proteins
pubmed
19806195
uniprot
proteins
pubmed
20693240
uniprot
proteins
pubmed
30250067
uniprot
proteins
sequence_length
575
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10887191}. Chromosome {ECO:0000269|PubMed:30250067}. Note=Accumulates at sites of DNA damage. {ECO:0000269|PubMed:30250067}.
uniprot
proteins