Ing4
entrez
28019
canonical
uniprot
Q8C0D7
canonical
ensembl
ENSMUSG00000030330
resolver
ensp
ENSMUSP00000032480
resolver
ensp
ENSMUSP00000121519
resolver
genesymbol
Ing4
resolver
uniprot
Q8C1S7
resolver
uniprot
Q8K3Q5
resolver
uniprot
Q8K3Q6
resolver
uniprot
Q8K3Q7
resolver
uniprot
Q9D7F9
resolver
uniprot_entry
ING4_MOUSE
resolver
uniprot_sec
Q8C1S7
resolver
uniprot_sec
Q8K3Q5
resolver
uniprot_sec
Q8K3Q6
resolver
uniprot_sec
Q8K3Q7
resolver
uniprot_sec
Q9D7F9
resolver
amino_acid_sequence
MAAGMYLEHYLDSIENLPFELQRNFQLMRDLDQRTEDLKAEIDKLATEYMSSARSLSSEEKLALLRQIQEAYGKCKEFGDDKVQLAMQTYEMVDKHIRRLDTDLARFEADLKEKQIESSDYDSSSSKGKKKGRTQKEKKAARARSKGKNSDEEAPKAAQKKLKLVRTSPEYGMPSVTFGSVHPSDVLDMPVDPNEPTYCLCHQVSYGEMIGCDNPDCSIEWFHFACVGLTTKPRGKWFCPRCSQERKKK
uniprot
proteins
function
FUNCTION: Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (By similarity). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (PubMed:11888890). {ECO:0000250|UniProtKB:Q9UNL4, ECO:0000269|PubMed:11888890}.
uniprot
proteins
mass_dalton
28528
uniprot
proteins
post_translational_modification
PTM: Citrullination by PADI4 within the nuclear localization signal disrupts the interaction with p53 and increases susceptibility to degradation. {ECO:0000250|UniProtKB:Q9UNL4}.
uniprot
proteins
protein_family
ING family
uniprot
proteins
pubmed
11888890
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
249
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11888890}.
uniprot
proteins