NR2C2
entrez
7182
canonical
uniprot
P49116
canonical
ensembl
ENSG00000177463
resolver
ensp
ENSP00000320447
resolver
ensp
ENSP00000388387
resolver
ensp
ENSP00000529312
resolver
ensp
ENSP00000638258
resolver
ensp
ENSP00000681965
resolver
genesymbol
NR2C2
resolver
genesymbol_syn
TAK1
resolver
genesymbol_syn
TR4
resolver
hgnc
HGNC:7972
resolver
uniprot
A0A024R2N9
resolver
uniprot
A8K3H5
resolver
uniprot
B6ZGT8
resolver
uniprot
F2YGU2
resolver
uniprot
P55092
resolver
uniprot_entry
F2YGU2_HUMAN
resolver
uniprot_entry
NR2C2_HUMAN
resolver
uniprot_sec
A0A024R2N9
resolver
uniprot_sec
A8K3H5
resolver
uniprot_sec
B6ZGT8
resolver
uniprot_sec
P55092
resolver
amino_acid_sequence
MTSPSPRIQIISTDSAVASPQRIQIVTDQQTGQKIQIVTAVDASGSPKQQFILTSPDGAGTGKVILASPETSSAKQLIFTTSDNLVPGRIQIVTDSASVERLLGKTDVQRPQVVEYCVVCGDKASGRHYGAVSCEGCKGFFKRSVRKNLTYSCRSNQDCIINKHHRNRCQFCRLKKCLEMGMKMESVQSERKPFDVQREKPSNCAASTEKIYIRKDLRSPLIATPTFVADKDGARQTGLLDPGMLVNIQQPLIREDGTVLLATDSKAETSQGALGTLANVVTSLANLSESLNNGDTSEIQPEDQSASEITRAFDTLAKALNTTDSSSSPSLADGIDTSGGGSIHVISRDQSTPIIEVEGPLLSDTHVTFKLTMPSPMPEYLNVHYICESASRLLFLSMHWARSIPAFQALGQDCNTSLVRACWNELFTLGLAQCAQVMSLSTILAAIVNHLQNSIQEDKLSGDRIKQVMEHIWKLQEFCNSMAKLDIDGYEYAYLKAIVLFSPDHPGLTSTSQIEKFQEKAQMELQDYVQKTYSEDTYRLARILVRLPALRLMSSNITEELFFTGLIGNVSIDSIIPYILKMETAEYNGQITGASL
uniprot
proteins
function
FUNCTION: Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation. {ECO:0000250, ECO:0000269|PubMed:10347174, ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:17974920, ECO:0000269|PubMed:7779113, ECO:0000269|PubMed:9556573}.
uniprot
proteins
mass_dalton
65414
uniprot
proteins
mutagenesis
MUTAGEN 576; /note="I->N: Reduces interaction with JAZF1."; /evidence="ECO:0000269|PubMed:15302918
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Ser-19 and Ser-68 is an important regulator of NR2C2-mediated transcriptional activity. Phosphorylation on these residues recruits the corepressor, NRIP1, leading to transcripional repression, whereas the non-phosphorylated form preferentially recruits the coactivator, PCAF (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
NR2 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
10347174
uniprot
proteins
pubmed
10644740
uniprot
proteins
pubmed
12486131
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15302918
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17974920
uniprot
proteins
pubmed
18388194
uniprot
proteins
pubmed
18619963
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
22672233
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
7708055
uniprot
proteins
pubmed
7779113
uniprot
proteins
pubmed
8016112
uniprot
proteins
pubmed
9556573
uniprot
proteins
sequence_length
596
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:10644740, ECO:0000269|PubMed:15302918}.
uniprot
proteins