Napepld
entrez
242864
canonical
uniprot
Q8BH82
canonical
ensembl
ENSMUSG00000044968
resolver
ensp
ENSMUSP00000054458
resolver
ensp
ENSMUSP00000110872
resolver
ensp
ENSMUSP00000338598
resolver
enst
ENSMUST00000060899
resolver
enst
ENSMUST00000115217
resolver
genesymbol
Napepld
resolver
genesymbol_syn
Mbldc1
resolver
uniprot_entry
NAPEP_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Activated by divalent cations (PubMed:17655883). Activated by bile acids (By similarity). Activated by membrane phospholipids such as phosphatidylethanolamines (PubMed:17655883). {ECO:0000250|UniProtKB:Q6IQ20, ECO:0000269|PubMed:17655883}.
uniprot
proteins
amino_acid_sequence
MDEYEDSQSPAPSYQYPKETLRKRQNSVQNSGGSVSSRFSRKSFKLDYRLEEDVTKSKKGKDGRFVNPWPTWKNISIPNVLRWLIMEKNHSGVPGSKEELDKELPVLKPYFVSDPEDAGVREAGLRVTWLGHATLMVEMDELIFLTDPMFSSRASPSQYMGPKRFRRPPCTISELPTIDAVLISHNHYDHLDYGSVLALNERFGSELRWFVPLGLLDWMQKCGCENVIELDWWEENCVPGHDKVTFVFTPSQHWCKRTLLDDNKVLWGSWSVLGPWSRFFFAGDTGYCPAFEEIGKRFGPFDLAAIPIGAYEPRWFMKYQHADPEDAVRIHIDLQTKRSVAIHWGTFALANEHYLEPPVKLNEALERYGLSCEDFFILKHGESRYLNTDDRAFEET
uniprot
proteins
ec_number
3.1.4.54
uniprot
proteins
function
FUNCTION: D-type phospholipase that hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce bioactive N-acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid (PubMed:14634025, PubMed:15760304, PubMed:17655883, PubMed:21801852). Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain (PubMed:16605240, PubMed:21801852). May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation (PubMed:31685899). As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose (PubMed:25757720). Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs (PubMed:14634025). {ECO:0000269|PubMed:14634025, ECO:0000269|PubMed:15760304, ECO:0000269|PubMed:16605240, ECO:0000269|PubMed:17655883, ECO:0000269|PubMed:21801852, ECO:0000269|PubMed:25757720, ECO:0000269|PubMed:31685899}.
uniprot
proteins
mass_dalton
45816
uniprot
proteins
protein_family
NAPE-PLD family
uniprot
proteins
pubmed
14634025
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15760304
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16605240
uniprot
proteins
pubmed
17655883
uniprot
proteins
pubmed
21801852
uniprot
proteins
pubmed
25757720
uniprot
proteins
pubmed
31685899
uniprot
proteins
sequence_length
396
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q6IQ20}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6IQ20}. Early endosome membrane {ECO:0000250|UniProtKB:Q6IQ20}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6IQ20}. Nucleus envelope {ECO:0000250|UniProtKB:Q6IQ20}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q6IQ20}. Note=Localized in the proximity of the cellular membranes likely through interaction with membrane phospholipids. {ECO:0000250|UniProtKB:Q6IQ20}.
uniprot
proteins