Flad1
entrez
751787
canonical
uniprot
D4A4P4
canonical
ensembl
ENSRNOG00000020642
resolver
ensembl
ENSRNOG00055026506
resolver
ensembl
ENSRNOG00060032162
resolver
ensembl
ENSRNOG00065026356
resolver
ensp
ENSRNOP00000028030
resolver
ensp
ENSRNOP00055037489
resolver
ensp
ENSRNOP00060046080
resolver
ensp
ENSRNOP00065037294
resolver
enst
ENSRNOT00055045740
resolver
enst
ENSRNOT00060055717
resolver
enst
ENSRNOT00065045490
resolver
genesymbol
Flad1
resolver
uniprot_entry
FAD1_RAT
resolver
amino_acid_sequence
MASRASELPPGRSVTAGIIIVGDEILKGHTQDTNTYFLCRTLRSLGVQVCRVSVVPDEVATIASEVTSFSRRFTHVLTAGGIGPTHDDVTFEAVALAFGEELKPHPELQAAIKTLGGEGWEKLSMVPSSARLHYGTDPGTGHPFRFPLVSVRNVYLFPGIPELLRRVLEGLKGLFQNTAVQFHLKELYVAASEGSIAPILSEAQAHFGRRLNLGSYPDWSSNYYQVKLILDSEEKEPLEECLAYLTARLPQGSLIPYLPDAVEKASEAVYKLAESGSCLGKKVAGALQTIETALAQYHLSQICVGFNGGKDCTALLHLFHAAVQRKFPDVPKPLQILYIRSISPFPELEQFLQDTIKRYNLQMLEAEGNMKQALGELQGKHPQLEAVLMGTRRTDPYSCSLHHFSPTDPGWPSFMRINPLLDWTYRNIWEFLRQLFVPYCILYDRGYTSLGSRENTKQNPALKCLSPGGHPVYRPAYLLENEDEERNSRM
uniprot
proteins
ec_number
2.7.7.2
uniprot
proteins
ec_number
3.6.1.18
uniprot
proteins
ec_number
3.6.1.22
uniprot
proteins
function
FUNCTION: This enzyme has two activities: FAD diphosphatase activity and FAD synthase activity (By similarity). FAD diphosphatase acts on FAD and NADH to produce FMN and NMNH(2-), respectively (By similarity). FAD synthase catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme (PubMed:9211336). In addition to its catalytic activities, the protein also facilitates the delivery of FAD to client apo-flavoproteins (By similarity). The balance between FAD synthesis and hydrolysis may be regulated by redox-sensing cysteine residues (By similarity). At a much lower rate, FAD synthase catalyzes the reverse pyrophosphorolytic reaction (By similarity). {ECO:0000250|UniProtKB:Q8NFF5, ECO:0000269|PubMed:9211336}.
uniprot
proteins
mass_dalton
54604
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1. {ECO:0000250|UniProtKB:Q8NFF5}.
uniprot
proteins
post_translational_modification
PTM: May form disulfide bonds. {ECO:0000250|UniProtKB:Q8NFF5}.
uniprot
proteins
protein_family
FAD1 subfamily; MoaB/Mog family
uniprot
proteins
protein_family
PAPS reductase family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
23946482
uniprot
proteins
pubmed
25954742
uniprot
proteins
pubmed
9211336
uniprot
proteins
sequence_length
490
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000305|PubMed:23946482}. Cytoplasm, cytosol {ECO:0000269|PubMed:23946482}. Nucleus {ECO:0000269|PubMed:23946482, ECO:0000269|PubMed:25954742}.
uniprot
proteins