Rce1
entrez
309153
canonical
uniprot
B0BMW8
canonical
ensembl
ENSRNOG00000019468
resolver
ensembl
ENSRNOG00055019229
resolver
ensembl
ENSRNOG00065032824
resolver
ensp
ENSRNOP00000026454
resolver
ensp
ENSRNOP00000059208
resolver
ensp
ENSRNOP00000090544
resolver
ensp
ENSRNOP00000110279
resolver
ensp
ENSRNOP00055026578
resolver
ensp
ENSRNOP00065046440
resolver
enst
ENSRNOT00000026454
resolver
enst
ENSRNOT00000066455
resolver
enst
ENSRNOT00000097288
resolver
enst
ENSRNOT00055032824
resolver
enst
ENSRNOT00065056453
resolver
genesymbol
Rce1
resolver
uniprot
A0A8I6GIA5
resolver
uniprot
G3V8J7
resolver
uniprot
Q5M955
resolver
uniprot_entry
A0A8I6GIA5_RAT
resolver
uniprot_entry
FACE2_RAT
resolver
uniprot_entry
G3V8J7_RAT
resolver
uniprot_entry
Q5M955_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Deubiquitination by USP17L2/USP17 negatively regulates the proteolytic activity toward Ras GTPases. {ECO:0000250|UniProtKB:Q9Y256}.
uniprot
proteins
amino_acid_sequence
MAALGGDGLRLLSVSRPERQPESAALSSPGPGLCCWVSVFSCFSLACSYVGSLYVWKSELPRDHPAVIKRRFTSVLVVSSLSPLCVLLWRELTGIQPGTSLLTLMGFRLEGIFPAALLPLLLTMILFLGPLMQLCMDCPCDLTDGLKVVLAPRSWARRLTDMRWLRNQVIAPLTEELVFRACMLPMLAPCTGLGPAVFTCPLFFGVAHFHHIIEQLRFRQSSVGSIFLSAGHLIGPVLCHSFCNYMGFPAVCAALEHPQKWPLLAGYALGVGLFLLLLQPLTDPKLYGSLPLCMLLERTGASETLLCS
uniprot
proteins
ec_number
3.4.26.1
uniprot
proteins
function
FUNCTION: Protease involved in the processing of a variety of prenylated proteins containing the C-terminal CAAX motif, where C is a cysteine modified with an isoprenoid lipid, A is an aliphatic amino acid and X is any C-terminal amino acid. Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins, leaving the prenylated cysteine as the new C-terminus. Is able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1 (By similarity). {ECO:0000250|UniProtKB:Q9Y256}.
uniprot
proteins
mass_dalton
33646
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Undergoes 'Lys-48'- and 'Lys-63'-linked ubiquitination. 'Lys-48' ubiquitination induces its degradation. Deubiquitinated by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains (By similarity). {ECO:0000250|UniProtKB:Q9Y256}.
uniprot
proteins
protein_family
Peptidase U48 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
308
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Y256}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9Y256}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..45; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 75..95; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 112..132; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 186..206; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 233..253; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 262..282; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins