SLC8A1
entrez
6546
canonical
uniprot
P32418
canonical
ensembl
ENSG00000183023
resolver
ensp
ENSP00000332931
resolver
ensp
ENSP00000383886
resolver
ensp
ENSP00000384908
resolver
ensp
ENSP00000385188
resolver
ensp
ENSP00000385678
resolver
ensp
ENSP00000412560
resolver
ensp
ENSP00000516109
resolver
ensp
ENSP00000516110
resolver
ensp
ENSP00000516141
resolver
ensp
ENSP00000516142
resolver
ensp
ENSP00000516143
resolver
ensp
ENSP00000622133
resolver
ensp
ENSP00000622134
resolver
ensp
ENSP00000622135
resolver
enst
ENST00000417271
resolver
enst
ENST00000705281
resolver
enst
ENST00000705282
resolver
enst
ENST00000705603
resolver
enst
ENST00000705605
resolver
genesymbol
SLC8A1
resolver
genesymbol_syn
CNC
resolver
genesymbol_syn
NCX1
resolver
hgnc
HGNC:11068
resolver
uniprot
A0A994J4U7
resolver
uniprot
A0A994J7E1
resolver
uniprot
A0A994J7G2
resolver
uniprot
A8K6N1
resolver
uniprot
D6W595
resolver
uniprot
E9PB98
resolver
uniprot
O95849
resolver
uniprot
Q4QQG6
resolver
uniprot
Q4QQH3
resolver
uniprot
Q587I6
resolver
uniprot
Q59GN4
resolver
uniprot
Q9UBL8
resolver
uniprot
Q9UD55
resolver
uniprot
Q9UDN1
resolver
uniprot
Q9UDN2
resolver
uniprot
Q9UKX6
resolver
uniprot_entry
A0A994J4U7_HUMAN
resolver
uniprot_entry
A0A994J7E1_HUMAN
resolver
uniprot_entry
A0A994J7G2_HUMAN
resolver
uniprot_entry
E9PB98_HUMAN
resolver
uniprot_entry
NAC1_HUMAN
resolver
uniprot_entry
Q4QQH3_HUMAN
resolver
uniprot_sec
A8K6N1
resolver
uniprot_sec
D6W595
resolver
uniprot_sec
O95849
resolver
uniprot_sec
Q4QQG6
resolver
uniprot_sec
Q587I6
resolver
uniprot_sec
Q59GN4
resolver
uniprot_sec
Q9UBL8
resolver
uniprot_sec
Q9UD55
resolver
uniprot_sec
Q9UDN1
resolver
uniprot_sec
Q9UDN2
resolver
uniprot_sec
Q9UKX6
resolver
activity_regulation
ACTIVITY REGULATION: Activated by micromolar levels of Ca(2+). {ECO:0000250|UniProtKB:Q01728}.
uniprot
proteins
amino_acid_sequence
MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGKYLFGQPVFRKVHAREHPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSSLEAYCHIKGF
uniprot
proteins
function
FUNCTION: Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:11241183, PubMed:1374913, PubMed:1476165). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle (PubMed:11241183, PubMed:1374913, PubMed:1476165). In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum (PubMed:11241183, PubMed:1374913, PubMed:1476165). SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline (PubMed:11241183, PubMed:1374913, PubMed:1476165). Required for normal embryonic heart development and the onset of heart contractions (By similarity). {ECO:0000250|UniProtKB:P70414, ECO:0000269|PubMed:11241183, ECO:0000269|PubMed:1374913, ECO:0000269|PubMed:1476165}.
uniprot
proteins
mass_dalton
108547
uniprot
proteins
protein_family
Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family
uniprot
proteins
protein_family
SLC8 subfamily
uniprot
proteins
pubmed
10908415
uniprot
proteins
pubmed
11241183
uniprot
proteins
pubmed
1374913
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
1476165
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
23376057
uniprot
proteins
pubmed
23506867
uniprot
proteins
pubmed
8048567
uniprot
proteins
sequence_length
973
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11241183, ECO:0000269|PubMed:1374913, ECO:0000269|PubMed:1476165}; Multi-pass membrane protein {ECO:0000269|PubMed:23376057}.
uniprot
proteins
transmembrane_region
TRANSMEM 75..95; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 137..157; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 171..191; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 205..225; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 232..252; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 801..821; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 825..845; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 875..895; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 907..927; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 945..965; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins