SESN3
entrez
143686
canonical
uniprot
P58005
canonical
ensembl
ENSG00000149212
resolver
ensp
ENSP00000278499
resolver
ensp
ENSP00000441927
resolver
genesymbol
SESN3
resolver
genesymbol_syn
SEST3
resolver
hgnc
HGNC:23060
resolver
uniprot
B7Z7P9
resolver
uniprot
Q96AD1
resolver
uniprot_entry
SESN3_HUMAN
resolver
uniprot_sec
B7Z7P9
resolver
uniprot_sec
Q96AD1
resolver
amino_acid_sequence
MNRGGGSPSAAANYLLCTNCRKVLRKDKRIRVSQPLTRGPSAFIPEKEVVQANTVDERTNFLVEEYSTSGRLDNITQVMSLHTQYLESFLRSQFYMLRMDGPLPLPYRHYIAIMAAARHQCSYLINMHVDEFLKTGGIAEWLNGLEYVPQRLKNLNEINKLLAHRPWLITKEHIQKLVKTGENNWSLPELVHAVVLLAHYHALASFVFGSGINPERDPEISNGFRLISVNNFCVCDLANDNNIENASLSGSNFGIVDSLSELEALMERMKRLQEEREDEEASQEEMSTRFEKEKKESLFVVSGDTFHSFPHSDFEDDMIITSDVSRYIEDPGFGYEDFARRGEEHLPTFRAQDYTWENHGFSLVNRLYSDIGHLLDEKFRMVYNLTYNTMATHEDVDTTMLRRALFNYVHCMFGIRYDDYDYGEVNQLLERSLKVYIKTVTCYPERTTKRMYDSYWRQFKHSEKVHVNLLLMEARMQAELLYALRAITRHLT
uniprot
proteins
ec_number
1.11.1.-
uniprot
proteins
function
FUNCTION: May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed:25263562). May also regulate the insulin-receptor signaling pathway through activation of TORC2 (By similarity). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). {ECO:0000250|UniProtKB:P58004, ECO:0000250|UniProtKB:Q9CYP7, ECO:0000269|PubMed:25263562}.
uniprot
proteins
mass_dalton
57291
uniprot
proteins
protein_family
Sestrin family
uniprot
proteins
pubmed
12607115
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
25259925
uniprot
proteins
pubmed
25263562
uniprot
proteins
pubmed
26449471
uniprot
proteins
sequence_length
492
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:25263562}.
uniprot
proteins