PTPN2
entrez
5771
canonical
uniprot
P17706
canonical
ensembl
ENSG00000175354
resolver
ensp
ENSP00000311857
resolver
ensp
ENSP00000320298
resolver
ensp
ENSP00000320546
resolver
ensp
ENSP00000466936
resolver
ensp
ENSP00000467823
resolver
ensp
ENSP00000655824
resolver
enst
ENST00000591497
resolver
genesymbol
PTPN2
resolver
genesymbol_syn
PTPT
resolver
hgnc
HGNC:9650
resolver
uniprot
A8K3N4
resolver
uniprot
A8K955
resolver
uniprot
A8MXU3
resolver
uniprot
K7ENG3
resolver
uniprot
K7EQG9
resolver
uniprot
Q59F91
resolver
uniprot
Q96AU5
resolver
uniprot
Q96HR2
resolver
uniprot_entry
A8K3N4_HUMAN
resolver
uniprot_entry
K7EQG9_HUMAN
resolver
uniprot_entry
PTN2_HUMAN
resolver
uniprot_entry
Q59F91_HUMAN
resolver
uniprot_sec
A8K955
resolver
uniprot_sec
A8MXU3
resolver
uniprot_sec
K7ENG3
resolver
uniprot_sec
Q96AU5
resolver
uniprot_sec
Q96HR2
resolver
amino_acid_sequence
MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKATTAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Also plays an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. May also bind DNA. {ECO:0000269|PubMed:10734133, ECO:0000269|PubMed:11909529, ECO:0000269|PubMed:12138178, ECO:0000269|PubMed:12612081, ECO:0000269|PubMed:14966296, ECO:0000269|PubMed:15592458, ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:22080863, ECO:0000269|PubMed:9488479}.
uniprot
proteins
mass_dalton
48473
uniprot
proteins
mutagenesis
MUTAGEN 182; /note="D->A: Substrate-trapping mutant; catalytically inactive it forms a stable complex with physiological substrates including INSR and EGFR. Accumulates in the cytoplasm upon stimulation by insulin or EGF; isoform 2."; /evidence="ECO:0000269|PubMed:12612081, ECO:0000269|PubMed:9488479"; MUTAGEN 222; /note="R->M: Impairs phosphatase activity."; MUTAGEN 304; /note="S->A: Alters phosphorylation by cyclin-dependent kinases of isoform 2 but has no effect on its phosphatase activity."; /evidence="ECO:0000269|PubMed:15030318"; MUTAGEN 350..352; /note="RKR->QQQ: Alters location to the endoplasmic reticulum; isoform 1."; /evidence="ECO:0000269|PubMed:7593185"; MUTAGEN 380; /note="K->Q: Prevents location to the nucleus; isoform 2."; /evidence="ECO:0000269|PubMed:7593185
uniprot
proteins
post_translational_modification
PTM: [Isoform 2]: Specifically phosphorylated in a cell cycle-dependent manner by cyclin-dependent kinases CDK1 and CDK2. Probably activated through phosphorylation by PKR. {ECO:0000269|PubMed:15030318, ECO:0000269|PubMed:16431927}.
uniprot
proteins
protein_family
Non-receptor class 1 subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
10734133
uniprot
proteins
pubmed
11907034
uniprot
proteins
pubmed
11909529
uniprot
proteins
pubmed
12138178
uniprot
proteins
pubmed
12359225
uniprot
proteins
pubmed
12612081
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14966296
uniprot
proteins
pubmed
15030318
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592458
uniprot
proteins
pubmed
15609043
uniprot
proteins
pubmed
15696169
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
16431927
uniprot
proteins
pubmed
16595549
uniprot
proteins
pubmed
17210636
uniprot
proteins
pubmed
1731319
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18819921
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22080863
uniprot
proteins
pubmed
23006999
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2546150
uniprot
proteins
pubmed
7593185
uniprot
proteins
pubmed
9361013
uniprot
proteins
pubmed
9488479
uniprot
proteins
sequence_length
415
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum {ECO:0000269|PubMed:7593185}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:7593185}. Note=Targeted to the endoplasmic reticulum by its C-terminal hydrophobic region. {ECO:0000269|PubMed:7593185}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus. Cytoplasm. Cell membrane. Note=Predominantly localizes to chromatin (By similarity). Able to shuttle between the nucleus and the cytoplasm and to dephosphorylate plasma membrane receptors (PubMed:9488479). Recruited by activated ITGA1 at the plasma membrane. {ECO:0000250, ECO:0000269|PubMed:9488479}.
uniprot
proteins