Chp2
entrez
308965
canonical
uniprot
Q810D1
canonical
ensembl
ENSRNOG00000019112
resolver
ensembl
ENSRNOG00065013066
resolver
ensp
ENSRNOP00000107025
resolver
ensp
ENSRNOP00065016581
resolver
enst
ENSRNOT00000163431
resolver
enst
ENSRNOT00065021424
resolver
genesymbol
Chp2
resolver
uniprot_entry
CHP2_RAT
resolver
amino_acid_sequence
MGSRSSHVALIPDVDQIRRETGFSQASLLRLYHRFQALDREEKGFLSRLDLQQIGALAVNPLGDRIIDSFFPNGSQRVYFAGFARVLAYFRPIDEDDATLRDPKQPEPLNSRMNKLRFAFQLYDLDRDGKISRNEMLQVLRLMVGVQVTDEQLESITDRTVQEADEDGDGAVSFLEFAKSLEKMNIEQKMSIRILK
uniprot
proteins
function
FUNCTION: Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
22486
uniprot
proteins
protein_family
CHP subfamily
uniprot
proteins
protein_family
Calcineurin regulatory subunit family
uniprot
proteins
pubmed
12576672
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
196
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12576672}. Nucleus {ECO:0000269|PubMed:12576672}. Cell membrane {ECO:0000269|PubMed:12576672}. Note=Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) pathway. May shuttle between nucleus and cytoplasm (By similarity). Predominantly localized in a juxtanuclear region. Colocalizes with SLC9A3 in the juxtanuclear region and at the plasma membrane. {ECO:0000250}.
uniprot
proteins