Ctnna2
entrez
12386
canonical
uniprot
Q61301
canonical
ensembl
ENSMUSG00000063063
resolver
ensp
ENSMUSP00000074809
resolver
ensp
ENSMUSP00000123714
resolver
ensp
ENSMUSP00000124376
resolver
ensp
ENSMUSP00000124764
resolver
genesymbol
Ctnna2
resolver
genesymbol_syn
Catna2
resolver
uniprot
Q3TY37
resolver
uniprot
Q61300
resolver
uniprot
Q6AXD1
resolver
uniprot_entry
CTNA2_MOUSE
resolver
uniprot_sec
Q3TY37
resolver
uniprot_sec
Q61300
resolver
uniprot_sec
Q6AXD1
resolver
amino_acid_sequence
MTSATSPIILKWDPKSLEIRTLTVERLLEPLVTQVTTLVNTSNKGPSGKKKGRSKKAHVLAASVEQATQNFLEKGEQIAKESQDLKEELVAAVEDVRKQGETMRIASSEFADDPCSSVKRGTMVRAARALLSAVTRLLILADMADVMRLLSHLKIVEEALEAVKNATNEQDLANRFKEFGKEMVKLNYVAARRQQELKDPHCRDEMAAARGALKKNATMLYTASQAFLRHPDVAATRANRDYVFKQVQEAIAGISSAAQATSPTDEAKGHTGIGELAAALNEFDNKIILDPMTFSEARFRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMNNTGRKEKGDPLNIAIDKMTKKTRDLRRQLRKAVMDHISDSFLETNVPLLVLIEAAKSGNEKEVKEYAQVFREHANKLVEVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDVFKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEATKLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIAGQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSRMDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGTGVQSTFTTFYEVDCDVIDGGRASQLSTHLPTCAEGAPIGSGSSDSSMLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQKVYGTAAVNSPVVSWKMKAPEKKPLVKREKPEEFQTRVRRGSQKKHISPVQALSEFKAMDSF
uniprot
proteins
function
FUNCTION: May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (PubMed:12123610, PubMed:15034585). Required for proper regulation of cortical neuronal migration and neurite growth. It acts as a negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization. It thereby suppresses excessive actin branching which would impair neurite growth and stability (By similarity). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (PubMed:12089526). {ECO:0000250|UniProtKB:P26232, ECO:0000269|PubMed:12089526, ECO:0000269|PubMed:12123610, ECO:0000269|PubMed:15034585}.
uniprot
proteins
mass_dalton
105286
uniprot
proteins
protein_family
Vinculin/alpha-catenin family
uniprot
proteins
pubmed
12089526
uniprot
proteins
pubmed
12123610
uniprot
proteins
pubmed
15034585
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16185771
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
16457793
uniprot
proteins
pubmed
16691566
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8174789
uniprot
proteins
sequence_length
953
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16457793}; Peripheral membrane protein {ECO:0000305|PubMed:16457793}; Cytoplasmic side {ECO:0000305|PubMed:16457793}. Cytoplasm {ECO:0000269|PubMed:16457793}. Cytoplasm, cytoskeleton {ECO:0000305|PubMed:15034585}. Cell junction, adherens junction {ECO:0000269|PubMed:16457793, ECO:0000269|PubMed:16691566}. Cell projection, axon {ECO:0000269|PubMed:16457793, ECO:0000269|PubMed:16691566}. Nucleus {ECO:0000250|UniProtKB:P26232}.
uniprot
proteins