RHOD
entrez
29984
canonical
uniprot
O00212
canonical
ensembl
ENSG00000173156
resolver
ensp
ENSP00000308576
resolver
ensp
ENSP00000432003
resolver
enst
ENST00000308831
resolver
enst
ENST00000532559
resolver
genesymbol
RHOD
resolver
genesymbol_syn
ARHD
resolver
hgnc
HGNC:670
resolver
uniprot
E9PIG5
resolver
uniprot_entry
E9PIG5_HUMAN
resolver
uniprot_entry
RHOD_HUMAN
resolver
amino_acid_sequence
MTAAQAAGEEAPPGVRSVKVVLVGDGGCGKTSLLMVFADGAFPESYTPTVFERYMVNLQVKGKPVHLHIWDTAGQDDYDRLRPLFYPDASVLLLCFDVTSPNSFDNIFNRWYPEVNHFCKKVPIIVVGCKTDLRKDKSLVNKLRRNGLEPVTYHRGQEMARSVGAVAYLECSARLHDNVHAVFQEAAEVALSSRGRNFWRRITQGFCVVT
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Involved in endosome dynamics. May coordinate membrane transport with the function of the cytoskeleton. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Participates in the reorganization of actin cytoskeleton; the function seems to involve WHAMM and includes regulation of filopodia formation and actin filament bundling. Can modulate the effect of DAPK3 in reorganization of actin cytoskeleton and focal adhesion dissolution. {ECO:0000269|PubMed:23087206, ECO:0000269|PubMed:23454120, ECO:0000269|PubMed:24102721}.
uniprot
proteins
mass_dalton
23466
uniprot
proteins
mutagenesis
MUTAGEN 207; /note="C->S: Abolishes endosomal localization."; /evidence="ECO:0000269|PubMed:23454120
uniprot
proteins
protein_family
Rho family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
12577064
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17064668
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
23087206
uniprot
proteins
pubmed
23454120
uniprot
proteins
pubmed
24102721
uniprot
proteins
pubmed
34114565
uniprot
proteins
pubmed
9116026
uniprot
proteins
sequence_length
210
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Early endosome {ECO:0000269|PubMed:24102721}. Note=Colocalizes with RAB5 to early endosomes (By similarity). {ECO:0000250|UniProtKB:P97348}.
uniprot
proteins