Setd1b
entrez
208043
canonical
uniprot
Q8CFT2
canonical
ensembl
ENSMUSG00000038384
resolver
ensp
ENSMUSP00000133933
resolver
genesymbol
Setd1b
resolver
genesymbol_syn
BC035291
resolver
genesymbol_syn
Kiaa1076
resolver
genesymbol_syn
Set1b
resolver
uniprot
Q3URP1
resolver
uniprot
Q80TK9
resolver
uniprot
Q8CFQ8
resolver
uniprot
Q8CGD1
resolver
uniprot_entry
Q3URP1_MOUSE
resolver
uniprot_entry
SET1B_MOUSE
resolver
uniprot_sec
Q80TK9
resolver
uniprot_sec
Q8CFQ8
resolver
uniprot_sec
Q8CGD1
resolver
amino_acid_sequence
MENSHPHHHHQQPPPQPGPSGERRNHHWRSYKLMIDPALKKGHHKLYRYDGQHFSLAMSSNRPVEIVEDPRVVGIWTKNKELELSVPKFKIDEFYVGPVPPKQVTFAKLNDNVRENFLRDMCKKYGEVEEVEILYNPKTKKHLGIAKVVFATVRGAKEAVQHLHSTSVMGNIIHVELDTKGETRMRFYELLVTGRYTPQTLPVGELDAISPIVSETLQLSDALKRLKDGSLSAGCGSGSSSVTPNSGGTPFSQDTAYSSCRLDTPNSYGQGTPITPRLGTPFSQDSSYSSRQPTPSYLFSQDPTATFKARRHESKFTDAYNRRHEHHYVHNSAVAGATAPFRGSSDLSFGTVGSSGTPFKAQSQDATTFAHTPPPAQTATASGFKSAFSPYQTPAPPFPPPPEEPTATAAFGSRDSGEFRRAPAPPPLPPAEPPAKEKPGTPPGPPPPDSNSMELGGRPTFGWSPEPCDSPGTPTLESSPAGPEKPHDSLDSRIEMLLKEQRTKLPFLREQDSDTEIQMEGSPISSSSSQLSPLSHFGTNSQPGFRGPSPPSSRPSSTGLEDISPTPLPDSDEDEDLGLGLGPRPPPEPGPPDPMGLLGQTAEVDLDLAGDRTPTSERMDEGQQSSGEDMEISDDEMPSAPITSADCPKPMVVTPGAGAVAAPNVLAPNLPLPPPPGFPPLPPPPPPPPPQPGFPMPPPLPPPPPPPPPAHPAVTVPPPPLPAPPGVPPPPILPPLPPFPPGLFPVMQVDMSHVLGGQWGGMPMSFQMQTQMLSRLMTGQGACPYPPFMAAAAAAASAGLQFVNLPPYRSPFSLSNSGPGRGQHWPPLPKFDPSVPPPGYIPRQEDPHKATVDGVLLVVLKELKAIMKRDLNRKMVEVVAFRAFDEWWDKKERMAKASLTPVKSGEHKDEDRPKPKDRIASCLLESWGKGEGLGYEGLGLGIGLRGAIRLPSFKVKRKEPPDTASSGDQKRLRPSTSVDEEDEESERERDRDIADAPCELTKRDPKSVGVRRRPGRPLELDSGGEEDEKESLSASSSSSASSSSGSSTTSPSSSASDKEEEDRESTEEEEEEEEEEAEEEEEEGPRSRISSPSSSSSSDKDDEDDNEADSDGQIDSDIDDQGAPLSEASEKDNGDSEEEETESITTSKAPAESSSSSSESSGSSEFESSSESESSSSSSEDEEEMTVPGVEEEEEEEEEEEKETAMAAATVVAMAEESMPPAGGQDFEQDRAEVPLGPRGPMRESLGTEEEVDIEAEDEVPEMQAPELEEPPLPMGARKLEGSPEPPEEPGPNTQGDMLLSPELPARETEEAQLPSPPEHGPESDLDMEPEPPPMLSLPLQPPLPPPRLLRPPSPPPEPETPEPPKPPVPLEPPPEDHPPRTPGLCGSLAKSQSTETVPATPGGEPPLSGSSSGLSLSSPQVPGSPFSYPSPSPGLSSGGLPRTPGRDFSFTPTFPEPSGPLLLPVCPLPTGRRDERTGPLASPVLLETGLPLPLPLPLPLPLALPVPVLRAQPRPPPQLPPLLPATLAPCPTPIKRKPGRPRRSPPSMLSLDGPLVRPPPGPALGRDLLLLPGQPPAPIFPSAHDPRAVTLDFRNTGIPAPPPPLPPQPPPPPPPPPVESTKLPFKELDNQWPSEAIPPGPRRDEVTEEYVDLAKVRGPWRRPPKKRHEDLVAPSASPEPSPPQPLFRPRSEFEEMTILYDIWNGGIDEEDIRFLCVTYERLLQQDNGMDWLNDTLWVYHPSTSLSSAKKKKREDGIREHVTGCARSEGFYTIDKKDKLRYLNSSRASTDEPPMDTQGMSIPAQPHASTRAGSERRSEQRRLLSSFTGSCDSDLLKFNQLKFRKKKLKFCKSHIHDWGLFAMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFRVDHDTIIDATKCGNFARFINHSCNPNCYAKVITVESQKKIVIYSKQHINVNEEITYDYKFPIEDVKIPCLCGSENCRGTLN
uniprot
proteins
ec_number
2.1.1.364
uniprot
proteins
function
FUNCTION: Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery, forms H3K4me1, H3K4me2 and H3K4me3 methylation marks at active chromatin sites where transcription and DNA repair take place (By similarity). Plays an essential role in regulating the transcriptional programming of multipotent hematopoietic progenitor cells and lymphoid lineage specification during hematopoiesis (PubMed:29916805). {ECO:0000250|UniProtKB:Q9UPS6, ECO:0000269|PubMed:29916805}.
uniprot
proteins
mass_dalton
215352
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17355966
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24550110
uniprot
proteins
pubmed
29916805
uniprot
proteins
sequence_length
1985
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24550110}. Nucleus speckle {ECO:0000250|UniProtKB:Q9UPS6}. Chromosome {ECO:0000250|UniProtKB:Q9UPS6}. Cytoplasm {ECO:0000250|UniProtKB:Q9UPS6}. Note=Localizes to a largely non-overlapping set of euchromatic nuclear speckles with SETD1A, suggesting that SETD1A and SETD1B each bind to a unique set of target genes (By similarity). Predominantly nuclear (By similarity). {ECO:0000250|UniProtKB:Q9UPS6}.
uniprot
proteins