NXT1
entrez
29107
canonical
uniprot
Q9UKK6
canonical
ensembl
ENSG00000132661
resolver
ensp
ENSP00000254998
resolver
ensp
ENSP00000597931
resolver
ensp
ENSP00000631920
resolver
enst
ENST00000254998
resolver
enst
ENST00000927872
resolver
enst
ENST00000961861
resolver
genesymbol
NXT1
resolver
hgnc
HGNC:15913
resolver
uniprot_entry
NXT1_HUMAN
resolver
amino_acid_sequence
MASVDFKTYVDQACRAAEEFVNVYYTTMDKRRRLLSRLYMGTATLVWNGNAVSGQESLSEFFEMLPSSEFQISVVDCQPVHDEATPSQTTVLVVICGSVKFEGNKQRDFNQNFILTAQASPSNTVWKIASDCFRFQDWAS
uniprot
proteins
function
FUNCTION: Stimulator of protein export for NES-containing proteins (PubMed:10567585). Also plays a role in the nuclear export of U1 snRNA, tRNA, and mRNA (PubMed:10848583). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 (PubMed:11259602, PubMed:19165146). {ECO:0000269|PubMed:10567585, ECO:0000269|PubMed:10848583, ECO:0000269|PubMed:11259602, ECO:0000269|PubMed:19165146}.
uniprot
proteins
mass_dalton
15847
uniprot
proteins
mutagenesis
MUTAGEN 114; /note="I->R: 70% reduction in mRNA export activity."; /evidence="ECO:0000269|PubMed:11583626"; MUTAGEN 134; /note="R->D: 57% reduction in mRNA export activity and loss of nuclear rim staining."; /evidence="ECO:0000269|PubMed:11583626
uniprot
proteins
pubmed
10567585
uniprot
proteins
pubmed
10848583
uniprot
proteins
pubmed
11259602
uniprot
proteins
pubmed
11583626
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14729961
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19165146
uniprot
proteins
pubmed
22814378
uniprot
proteins
sequence_length
140
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Nucleus speckle {ECO:0000305}. Cytoplasm. Note=Shuttles between the nucleus and the cytoplasm.
uniprot
proteins