EZR
entrez
7430
canonical
uniprot
P15311
canonical
ensembl
ENSG00000092820
resolver
ensp
ENSP00000338934
resolver
ensp
ENSP00000356042
resolver
ensp
ENSP00000522664
resolver
ensp
ENSP00000522665
resolver
ensp
ENSP00000593559
resolver
ensp
ENSP00000593561
resolver
enst
ENST00000337147
resolver
enst
ENST00000367075
resolver
enst
ENST00000852605
resolver
enst
ENST00000852606
resolver
enst
ENST00000923500
resolver
enst
ENST00000923502
resolver
genesymbol
EZR
resolver
genesymbol_syn
VIL2
resolver
hgnc
HGNC:12691
resolver
uniprot
E1P5A8
resolver
uniprot
P23714
resolver
uniprot
Q4VX75
resolver
uniprot
Q96CU8
resolver
uniprot
Q9NSJ4
resolver
uniprot_entry
EZRI_HUMAN
resolver
uniprot_sec
E1P5A8
resolver
uniprot_sec
P23714
resolver
uniprot_sec
Q4VX75
resolver
uniprot_sec
Q96CU8
resolver
uniprot_sec
Q9NSJ4
resolver
activity_regulation
ACTIVITY REGULATION: A head-to-tail association, of the N-terminal and C-terminal halves results in a closed conformation (inactive form) which is incapable of actin or membrane-binding. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLHYVDNKGFPTWLKLDKKVSAQEVRKENPLQFKFRAKFYPEDVAEELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEVHKSGYLSSERLIPQRVMDQHKLTRDQWEDRIQVWHAEHRGMLKDNAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMMREKEELMLRLQDYEEKTKKAERELSEQIQRALQLEEERKRAQEEAERLEADRMAALRAKEELERQAVDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVSYHVQESLQDEGAEPTGYSAELSSEGIRDDRNEEKRITEAEKNERVQRQLLTLSSELSQARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAL
uniprot
proteins
function
FUNCTION: Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis. {ECO:0000269|PubMed:17881735, ECO:0000269|PubMed:18270268, ECO:0000269|PubMed:19111582}.
uniprot
proteins
mass_dalton
69413
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by tyrosine-protein kinases. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding (By similarity). {ECO:0000250}.; PTM: S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex. {ECO:0000305|PubMed:25417112}.
uniprot
proteins
pubmed
12429733
uniprot
proteins
pubmed
12651155
uniprot
proteins
pubmed
12808036
uniprot
proteins
pubmed
1381389
uniprot
proteins
pubmed
1382070
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498789
uniprot
proteins
pubmed
15797715
uniprot
proteins
pubmed
17046996
uniprot
proteins
pubmed
17616675
uniprot
proteins
pubmed
17881735
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18046454
uniprot
proteins
pubmed
18270268
uniprot
proteins
pubmed
19111582
uniprot
proteins
pubmed
19555689
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25417112
uniprot
proteins
pubmed
2591371
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
2674140
uniprot
proteins
pubmed
27364155
uniprot
proteins
pubmed
8713105
uniprot
proteins
pubmed
9314537
uniprot
proteins
sequence_length
586
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:18046454}; Peripheral membrane protein {ECO:0000269|PubMed:18046454}; Cytoplasmic side {ECO:0000269|PubMed:18046454}. Cell projection {ECO:0000269|PubMed:18046454}. Cell projection, microvillus membrane {ECO:0000269|PubMed:18046454}; Peripheral membrane protein {ECO:0000269|PubMed:18046454}; Cytoplasmic side {ECO:0000269|PubMed:18046454}. Cell projection, ruffle membrane {ECO:0000269|PubMed:18046454}; Peripheral membrane protein {ECO:0000269|PubMed:18046454}; Cytoplasmic side {ECO:0000269|PubMed:18046454}. Cytoplasm, cell cortex {ECO:0000269|PubMed:18046454}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18046454}. Cell projection, microvillus {ECO:0000250|UniProtKB:P26040}. Note=Localization to the apical membrane of parietal cells depends on the interaction with PALS1. Localizes to cell extensions and peripheral processes of astrocytes (By similarity). Microvillar peripheral membrane protein (cytoplasmic side). {ECO:0000250|UniProtKB:P31977}.
uniprot
proteins