Edn1
entrez
24323
canonical
uniprot
P22388
canonical
ensembl
ENSRNOG00000014361
resolver
ensembl
ENSRNOG00055007747
resolver
ensembl
ENSRNOG00060008487
resolver
ensembl
ENSRNOG00065008479
resolver
ensp
ENSRNOP00000019361
resolver
ensp
ENSRNOP00055010350
resolver
ensp
ENSRNOP00060010853
resolver
ensp
ENSRNOP00065009971
resolver
enst
ENSRNOT00000019361
resolver
enst
ENSRNOT00055012966
resolver
enst
ENSRNOT00060014155
resolver
enst
ENSRNOT00065013446
resolver
genesymbol
Edn1
resolver
uniprot_entry
EDN1_RAT
resolver
amino_acid_sequence
MDYFPVIFSLLFVAFQGAPETAVLGAELSPRAEKEVQSPPPSTSWRPRRSKRCSCSSLMDKECVYFCHLDIIWVNTPERVVPYGLGSPSRSKRSLKDLLPTKTTDQGNRCQCAHQKDKKCWNFCQADKELRAQSTMQKGVKDFKKGKPCPKLGKKCIYQQLVEGRKLRRLEAISNSIKTSFRVAKLKAELYRDQKLIHNRAH
uniprot
proteins
function
FUNCTION: Endothelins are endothelium-derived vasoconstrictor peptides (By similarity). Probable ligand for G protein-coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (PubMed:9508787). Promotes mesenteric arterial wall remodeling via activation of ROCK signaling and subsequent colocalization of NFATC3 with F-actin filaments (By similarity). NFATC3 then translocates to the nucleus where it subsequently promotes the transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity). {ECO:0000250|UniProtKB:P05305, ECO:0000250|UniProtKB:P09558, ECO:0000250|UniProtKB:P22387, ECO:0000269|PubMed:9508787}.
uniprot
proteins
mass_dalton
23135
uniprot
proteins
protein_family
Endothelin/sarafotoxin family
uniprot
proteins
pubmed
1840483
uniprot
proteins
pubmed
2039460
uniprot
proteins
pubmed
26479776
uniprot
proteins
pubmed
9508787
uniprot
proteins
sequence_length
202
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins