Kif26b
entrez
269152
canonical
uniprot
Q7TNC6
canonical
ensembl
ENSMUSG00000026494
resolver
ensp
ENSMUSP00000124462
resolver
ensp
ENSMUSP00000124608
resolver
enst
ENSMUST00000161017
resolver
genesymbol
Kif26b
resolver
uniprot
B0G0X9
resolver
uniprot
D5MP63
resolver
uniprot
E9PXV6
resolver
uniprot
Q0VB48
resolver
uniprot
Q8BHX2
resolver
uniprot
Q8BKH6
resolver
uniprot_entry
B0G0X9_MOUSE
resolver
uniprot_entry
KI26B_MOUSE
resolver
uniprot_sec
D5MP63
resolver
uniprot_sec
E9PXV6
resolver
uniprot_sec
Q0VB48
resolver
uniprot_sec
Q8BHX2
resolver
uniprot_sec
Q8BKH6
resolver
amino_acid_sequence
MNSVAGNKERLAVSTRGKKYGVNEMCSPTKPSAPCSPESWYRKAYEESRAGSRPTPEGAGSALGSSGTPSPGSGTSSPSSFTGSPGPASPGIGTSSPGSLGGSPGFGTGSPGSGSGGGSSPGSDRGVWCENCNARLVELKRQALKLLLPGPLPGKDPAFSAVIHDKLQVPNTIRKSWNDRDNRCDICATHLNQLKQEAIQMVLTLEQAAGSEHYDTSLGSPPPISSIPTLVGSRHMGGLQQPREWAFVPAPYATSTYTGLVNKHSGKPNSLGVSNGAEKKSGSPTHQAKVSLQMATSPSNGNILNSVAIQAHQYLDGTWSLSRTNGVTLYPYQISQLMTETGREGLTESALNRYNADKPAASSVPAPQGSCVASETSTGTSVAASFFARAAQKLNLSSKKKKHRPSTPSVAEAPLFATSFSGILQTSPPPAPPCLLRAVNKVKDTPGMGKVKVMLRICSTSARDTSESSSFLKVDPRKKQITLYDPLTCGGQNAFQKRSSQVPPKMFAFDAVFPQDASQAEVCAGTVAEVIQSVVNGADGCVFCFGHAKLGKSYTMIGRDDSMQNLGIIPCAISWLFKLINERKEKTGARFSVRISAVEVWGKEENLRDLLSEVATGSLQDGQSPGVYLCEDPICGTQLQNQSELRAPTAEKAAFFLDAAIASRRSNQQDCDEDDHRNSHMLFTLHIYQYRMEKSGKGGMSGGRSRLHLIDLGSCVKALSKNREGGSGLCLSLSALGNVILALVNGSKHIPYKESKLTMLLRESLGNVNCRTTMIAHISAAASSYAETLSTIQIASRVLRMKKKKTKYTSSSSGGESSCEEGRMRRPTQLRPFHARAPVDPEFPLAPLSSDPDYSSSSEQSCDTVIYIGPNGTALSDKELTDNEGPPDFVPIVPALQKTRGDSRPGEAAEAAASKSERDCLKCNTFAELQERLDCIDGSEEPSKFPFEELPIQFGPEQAGRCAPLSQAVGPDTPSESEKEDNGSDNGQLTEREGTELPASKAQRNRSPAPTVTRSSSPSPASPRSIPGSSSQHSTSQLTQSPSLQSSRESLNSCGFVEGKPRPMGSPRLGIASLSKTSEYKPPSSPSQRCKVYTQKGVLPSSAPPPSLSKDSGMVSSESLLQPDVRTPPVGMSPQVLKKSMSAGSEGFPGTLVDGEDQEGPPADSKKEILSTTMVTVQQPLELNGEDELVFTLVEELTISGVLDSGRPTSIISFNSDCSVQALASGSRPVSIISSISEDLECYSSMAPVSEVSITQFLPLPKLGLDEKARDAGSRRSSISSWLSEMSAGSDGEQSCHSFIAQTCFGHGEAMAEPPASEFVSSIQNTAVVCREKPEVGPDNLLILSEMGEESGNKAAPIKGCKISTVGKAMVTISNTASLSSCEGYIPMKTNITVYPCIAMSPRNVQEPESSTATPKVSPKASQAQESKEPSTRREMKFEDPWLKREEEVKRENAYSSEEGVKCEPLPSSLKTEGKSEQELDGRPSSGNRLSSSSSEAAAFQGTDNVRRVVDGCEMALPGLVAQSPLHVNRNLKSSSLPRAFQKADRHEELDSFYHCLADSNGFSAASGIPSSKTTLERKVASPKHCVLARPKGTPPLPPVRKSSLDQKNRASPQHGGGSSNTSSPLNQPATFLACFPDESNGKTKDVSSSSKLFSAKLEQLASRSNSLGRTTVSHYECLSLERAESLSSVSSRMHAGKDSTMPRTGRSLGRSTGASPPSCGITQSTGASPKASQSKISAVSKLLLASPKSRSSLSTSTTKTLSFSTKSLPQSVGQSSNLPPSGKHMSWSTQSLSRNRGSGLASKLPLRAVNGRISELLQGSAGPRSAQLRAEAEERSGAPSEDKPAAAHLLPSPYSKITPPRKPHRCSSGHGSDNSSVLSGELPPAMGKTALFYHSGGSSGYESMMRDSEATGSASSAQDSMSENSSSVGGRCRSLKNQKKRSNSGSQRRRLIPALSLDTPSPVRKTASSTGVRWVDGPLRSTQRSLGEPFEIKVYEIDDVERLQRRRGATSKEVMCFNAKLKILEHRQQRIAEVRAKYEWLMKELEATKQYLMLDPNKWLREFDLEQVLQLDSLEYLEALEGVTERLESRVNFCKAHLMMITCFDITSRRR
uniprot
proteins
function
FUNCTION: Essential for embryonic kidney development. Plays an important role in the compact adhesion between mesenchymal cells adjacent to the ureteric buds, possibly by interacting with MYH10. This could lead to the establishment of the basolateral integrity of the mesenchyme and the polarized expression of ITGA8, which maintains the GDNF expression required for further ureteric bud attraction. Although it seems to lack ATPase activity it is constitutively associated with microtubules. {ECO:0000269|PubMed:20439720, ECO:0000269|PubMed:22768111}.
uniprot
proteins
mass_dalton
225511
uniprot
proteins
mutagenesis
MUTAGEN 1859; /note="T->A: Reduced polyubiquitination when co-expressed with NEDD4; when associated with Ala-1962."; /evidence="ECO:0000269|PubMed:22768111"; MUTAGEN 1962; /note="S->A: Reduced polyubiquitination when co-expressed with NEDD4; when associated with Ala-1859."; /evidence="ECO:0000269|PubMed:22768111
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-1859 and Ser-1962 by CDKs, mainly CDK2 and CDK5, enhances the interaction with NEDD4, polyubiquitination, and subsequent proteasomal degradation. Phosphorylation occurs upon loss of interaction with microtubules. {ECO:0000269|PubMed:22768111}.; PTM: Polyubiquitinated by NEDD4, resulting in proteasomal degradation.
uniprot
proteins
protein_family
KIF26 subfamily
uniprot
proteins
protein_family
Kinesin family
uniprot
proteins
protein_family
TRAFAC class myosin-kinesin ATPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20439720
uniprot
proteins
pubmed
22768111
uniprot
proteins
sequence_length
2112
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20439720}. Cytoplasm, cytoskeleton {ECO:0000305|PubMed:20439720}.
uniprot
proteins