Hey2
entrez
15214
canonical
uniprot
Q9QUS4
canonical
ensembl
ENSMUSG00000019789
resolver
ensp
ENSMUSP00000019924
resolver
enst
ENSMUST00000019924
resolver
genesymbol
Hey2
resolver
genesymbol_syn
Chf1
resolver
genesymbol_syn
Herp
resolver
genesymbol_syn
Herp1
resolver
genesymbol_syn
Hesr2
resolver
genesymbol_syn
Hrt2
resolver
uniprot
Q0VGJ1
resolver
uniprot
Q3TZ99
resolver
uniprot
Q8CD44
resolver
uniprot_entry
HEY2_MOUSE
resolver
uniprot_entry
Q0VGJ1_MOUSE
resolver
uniprot_sec
Q3TZ99
resolver
uniprot_sec
Q8CD44
resolver
amino_acid_sequence
MKRPCEETTSESDLDETIDVGSENNYPGHATSSVMRSNSPTTTSQIMARKKRRGIIEKRRRDRINNSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHALATDFMSIGFRECLTEVARYLSSVEGLDPSDPLRVRLVSHLSTCASQREAAVMTSSMAHHHHPLHPHHWAAAFHHLPTALLQPNGLHTSESTPCRLSTSSEVPSAHGSALLTATFAHADSALRMPSGGTVAPCVPPLSTSLLSLSATVHAAAAAATAAAHSFPLSFAGAFPMLPSNAAAAAAVAAATAISPPLSVSAASSPQQTSTGTNNKPYQPWGTEVGAF
uniprot
proteins
function
FUNCTION: Transcriptional repressor which functions as a downstream effector of Notch signaling in cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY1 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3. {ECO:0000269|PubMed:10692439, ECO:0000269|PubMed:11095750, ECO:0000269|PubMed:11160397, ECO:0000269|PubMed:11486045, ECO:0000269|PubMed:12372253, ECO:0000269|PubMed:12372254, ECO:0000269|PubMed:12454287, ECO:0000269|PubMed:12947105, ECO:0000269|PubMed:15107403, ECO:0000269|PubMed:15297376, ECO:0000269|PubMed:15345511, ECO:0000269|PubMed:15485867, ECO:0000269|PubMed:15680351, ECO:0000269|PubMed:16199874, ECO:0000269|PubMed:17259303, ECO:0000269|PubMed:17303760, ECO:0000269|PubMed:17332425}.
uniprot
proteins
mass_dalton
35873
uniprot
proteins
mutagenesis
MUTAGEN 33..37; /note="Missing: Abrogates interaction with GATA4 and repression of GATA4-mediated transcription."; /evidence="ECO:0000269|PubMed:15485867"; MUTAGEN 49..61; /note="RKKRRGIIEKRRR->LE: Abrogates DNA-binding and transcriptional repression."; /evidence="ECO:0000269|PubMed:11095750
uniprot
proteins
protein_family
HEY family
uniprot
proteins
pubmed
10415358
uniprot
proteins
pubmed
10588864
uniprot
proteins
pubmed
10692439
uniprot
proteins
pubmed
10860664
uniprot
proteins
pubmed
10964718
uniprot
proteins
pubmed
11095750
uniprot
proteins
pubmed
11160397
uniprot
proteins
pubmed
11486044
uniprot
proteins
pubmed
11486045
uniprot
proteins
pubmed
11741889
uniprot
proteins
pubmed
12372253
uniprot
proteins
pubmed
12372254
uniprot
proteins
pubmed
12454287
uniprot
proteins
pubmed
12947105
uniprot
proteins
pubmed
15107403
uniprot
proteins
pubmed
15297376
uniprot
proteins
pubmed
15345511
uniprot
proteins
pubmed
15485867
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15680351
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16199874
uniprot
proteins
pubmed
17259303
uniprot
proteins
pubmed
17303760
uniprot
proteins
pubmed
17332425
uniprot
proteins
sequence_length
339
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:11741889}.
uniprot
proteins