Klhl2
entrez
290692
canonical
uniprot
F1LZF0
canonical
ensembl
ENSRNOG00000029441
resolver
ensembl
ENSRNOG00055013284
resolver
ensembl
ENSRNOG00060015283
resolver
ensembl
ENSRNOG00065005032
resolver
ensp
ENSRNOP00000049839
resolver
ensp
ENSRNOP00000100793
resolver
ensp
ENSRNOP00055018497
resolver
ensp
ENSRNOP00060021010
resolver
ensp
ENSRNOP00065005120
resolver
enst
ENSRNOT00000173315
resolver
enst
ENSRNOT00055022799
resolver
enst
ENSRNOT00060026254
resolver
enst
ENSRNOT00065007369
resolver
genesymbol
Klhl2
resolver
uniprot_entry
KLHL2_RAT
resolver
amino_acid_sequence
MESPPLPPACTKQGHQKPLDSKDENPEKHCPLTVNPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEIPAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRMLMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATANEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL
uniprot
proteins
function
FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, WNK1, WNK3 and WNK4, leading most often to their proteasomal degradation (By similarity). The BCR(KLHL2) complex catalyzes ubiquitination and degradation of NPTXR (By similarity). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4 (By similarity). Plays a role in the reorganization of the actin cytoskeleton (PubMed:15715669, PubMed:20504342). Promotes growth of cell projections in oligodendrocyte precursors (PubMed:15715669, PubMed:20504342). {ECO:0000250|UniProtKB:O95198, ECO:0000250|UniProtKB:Q8JZP3, ECO:0000269|PubMed:15715669, ECO:0000269|PubMed:20504342}.
uniprot
proteins
mass_dalton
65983
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:O95198}.
uniprot
proteins
pubmed
10397770
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15715669
uniprot
proteins
pubmed
20504342
uniprot
proteins
sequence_length
593
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O95198}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q8JZP3}. Cell projection {ECO:0000250|UniProtKB:O95198}. Cell projection, lamellipodium {ECO:0000269|PubMed:20504342}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8JZP3}. Note=A proportion colocalizes with the actin cytoskeleton (By similarity). When over-expressed, colocalizes with NPTXR in perinuclear aggresomes (By similarity). {ECO:0000250|UniProtKB:O95198, ECO:0000250|UniProtKB:Q8JZP3}.
uniprot
proteins