Fcer1g
entrez
14127
canonical
uniprot
P20491
canonical
ensembl
ENSMUSG00000058715
resolver
ensp
ENSMUSP00000078875
resolver
enst
ENSMUST00000079957
resolver
genesymbol
Fcer1g
resolver
genesymbol_syn
Fce1g
resolver
uniprot_entry
FCERG_MOUSE
resolver
amino_acid_sequence
MISAVILFLLLLVEQAAALGEPQLCYILDAVLFLYGIVLTLLYCRLKIQVRKAAIASREKADAVYTGLNTRSQETYETLKHEKPPQ
uniprot
proteins
function
FUNCTION: Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells (PubMed:14764707). As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset (PubMed:19098920). Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (Probable) (PubMed:23602766). May function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation (PubMed:17086186). Also involved in integrin alpha-2/ITGA2-mediated platelet activation (PubMed:9171347). {ECO:0000269|PubMed:14764707, ECO:0000269|PubMed:17086186, ECO:0000269|PubMed:19098920, ECO:0000269|PubMed:23602766, ECO:0000269|PubMed:9171347, ECO:0000305}.
uniprot
proteins
mass_dalton
9652
uniprot
proteins
mutagenesis
MUTAGEN 29; /note="D->A: Increases IL3-induced production of IL4 by basophils."; /evidence="ECO:0000269|PubMed:19098920"; MUTAGEN 39; /note="L->A: Impairs interaction with CSF2RB. Impairs IL3-induced production of IL4 by basophils."; /evidence="ECO:0000269|PubMed:19098920"; MUTAGEN 65..86; /note="Missing: Impairs IgE-induced mast cell activation in the presence of antigen; Impairs IgE-induced mast cell survival in the absence of antigen."; /evidence="ECO:0000269|PubMed:14764707"; MUTAGEN 65; /note="Y->P: Impairs IgE-induced mast cell activation in the presence of antigen; Impairs IgE-induced mast cell survival in the absence of antigen; when associated with P-76. Impairs IL3-induced production of IL4 by basophils; when associated with P-76."; /evidence="ECO:0000269|PubMed:14764707, ECO:0000269|PubMed:19098920"; MUTAGEN 76; /note="Y->P: Impairs IgE-induced mast cell activation in the presence of antigen; Impairs IgE-induced mast cell survival in the absence of antigen; when associated with P-65. Impairs IL3-induced production of IL4 by basophils; when associated with P-65."; /evidence="ECO:0000269|PubMed:14764707, ECO:0000269|PubMed:19098920
uniprot
proteins
protein_family
CD3Z/FCER1G family
uniprot
proteins
pubmed
14764707
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17050534
uniprot
proteins
pubmed
17086186
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
18776906
uniprot
proteins
pubmed
19098920
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
20817736
uniprot
proteins
pubmed
23602766
uniprot
proteins
pubmed
2527850
uniprot
proteins
pubmed
9171347
uniprot
proteins
sequence_length
86
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 24..44; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins