MEIOB
entrez
254528
canonical
uniprot
Q8N635
canonical
ensembl
ENSG00000162039
resolver
ensp
ENSP00000314484
resolver
ensp
ENSP00000380504
resolver
genesymbol
MEIOB
resolver
genesymbol_syn
C16orf73
resolver
hgnc
HGNC:28569
resolver
uniprot
B1AK39
resolver
uniprot
C9J0S1
resolver
uniprot
Q96RY0
resolver
uniprot_entry
MEIOB_HUMAN
resolver
uniprot_sec
B1AK39
resolver
uniprot_sec
C9J0S1
resolver
uniprot_sec
Q96RY0
resolver
amino_acid_sequence
MANSFAARIFTTLSDLQTNMANLKVIGIVIGKTDVKGFPDRKNIGSERYTFSFTIRDSPAHFVNAASWGNEDYIKSLSDSFRVGDCVIIENPLIQRKEIEREEKFSPATPSNCKLLLSENHSTVKVCSSYEVDTKLLSLIHLPVKESHDYYSLGDIVANGHSLNGRIINVLAAVKSVGEPKYFTTSDRRKGQRCEVRLYDETESSFAMTCWDNESILLAQSWMPRETVIFASDVRINFDKFRNCMTATVISKTIITTNPDIPEANILLNFIRENKETNVLDDEIDSYFKESINLSTIVDVYTVEQLKGKALKNEGKADPSYGILYAYISTLNIDDETTKVVRNRCSSCGYIVNEASNMCTTCNKNSLDFKSVFLSFHVLIDLTDHTGTLHSCSLTGSVAEETLGCTFVLSHRARSGLKISVLSCKLADPTEASRNLSGQKHV
uniprot
proteins
disease_involvement
DISEASE: Spermatogenic failure 22 (SPGF22) [MIM:617706]: An infertility disorder caused by spermatogenesis defects that result in non-obstructive azoospermia. {ECO:0000269|PubMed:28206990, ECO:0000269|PubMed:32741963, ECO:0000269|PubMed:33166385, ECO:0000269|PubMed:37715646}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Premature ovarian failure 23 (POF23) [MIM:620686]: A form of premature ovarian failure, an ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. POF23 inheritance is autosomal recessive. {ECO:0000269|PubMed:31000419, ECO:0000269|PubMed:35991565}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro. {ECO:0000250|UniProtKB:Q9D513}.
uniprot
proteins
mass_dalton
49313
uniprot
proteins
mutagenesis
MUTAGEN 188..190; /note="RRK->AAA: Strongly reduces nuclear localization."; /evidence="ECO:0000269|PubMed:36331299"; MUTAGEN 240; /note="K->A: Reduces nuclear localization; when associated with A-242."; /evidence="ECO:0000269|PubMed:36331299"; MUTAGEN 242; /note="R->A: Reduces nuclear localization; when associated with A-240."; /evidence="ECO:0000269|PubMed:36331299
uniprot
proteins
protein_family
MEIOB family
uniprot
proteins
pubmed
11157797
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
24068956
uniprot
proteins
pubmed
28206990
uniprot
proteins
pubmed
31000419
uniprot
proteins
pubmed
32741963
uniprot
proteins
pubmed
33166385
uniprot
proteins
pubmed
34392356
uniprot
proteins
pubmed
35991565
uniprot
proteins
pubmed
36331299
uniprot
proteins
pubmed
37715646
uniprot
proteins
pubmed
40296718
uniprot
proteins
sequence_length
442
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:36331299}. Nucleus {ECO:0000269|PubMed:35991565, ECO:0000269|PubMed:36331299}. Chromosome {ECO:0000250|UniProtKB:Q9D513}. Note=Co-localizes with the RPA complex on meiotic chromosome axes. Accumulates on resected DNA. Localization is dependent on SPATA22. {ECO:0000250|UniProtKB:Q9D513, ECO:0000269|PubMed:36331299}.
uniprot
proteins