DMWD
entrez
1762
canonical
uniprot
Q09019
canonical
ensembl
ENSG00000185800
resolver
ensp
ENSP00000270223
resolver
enst
ENST00000270223
resolver
genesymbol
DMWD
resolver
genesymbol_syn
DM9
resolver
hgnc
HGNC:2936
resolver
uniprot
Q8WUW6
resolver
uniprot_entry
DMWD_HUMAN
resolver
uniprot_entry
Q8WUW6_HUMAN
resolver
amino_acid_sequence
MAAGGAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPPPGPASASGPGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGGDRVCFNLGRELYFYPGCCRRGSQRSIDLNKPIDKRIYKGTQPTCHDFNQFTAATETISLLVGFSAGQVQYLDLIKKDTSKLFNEERLIDKTKVTYLKWLPESESLFLASHASGHLYLYNVSHPCASAPPQYSLLKQGEGFSVYAAKSKAPRNPLAKWAVGEGPLNEFAFSPDGRHLACVSQDGCLRVFHFDSMLLRGLMKSYFGGLLCVCWSPDGRYVVTGGEDDLVTVWSFTEGRVVARGHGHKSWVNAVAFDPYTTRAEEAATAAGADGERSGEEEEEEPEAAGTGSAGGAPLSPLPKAGSITYRFGSAGQDTQFCLWDLTEDVLYPHPPLARTRTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEKPSGPVPRSRLDPAKVLGTALCPRIHEVPLLEPLVCKKIAQERLTVLLFLEDCIITACQEGLICTWARPGKAFTDEETEAQTGEGSWPRSPSKSVVEGISSQPGNSPSGTVV
uniprot
proteins
function
FUNCTION: Regulator of the deubiquitinating USP12/DMWD/WDR48 complex (PubMed:33844468). Functions as a cofactor that promotes USP12 enzymatic activity (PubMed:33844468). {ECO:0000269|PubMed:33844468}.
uniprot
proteins
mass_dalton
70438
uniprot
proteins
mutagenesis
MUTAGEN 326; /note="F->A: Impairs binding to USP12."; /evidence="ECO:0000269|PubMed:33844468"; MUTAGEN 370; /note="W->A: Impairs binding to USP12."; /evidence="ECO:0000269|PubMed:33844468
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
33844468
uniprot
proteins
pubmed
7905855
uniprot
proteins
pubmed
8499920
uniprot
proteins
sequence_length
674
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:33844468}. Nucleus {ECO:0000269|PubMed:33844468}. Perikaryon {ECO:0000250|UniProtKB:Q08274}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q08274}. Note=Localizes mainly to the cytoplasm however shuttles between the cytoplasm and nucleus (PubMed:33844468). In neurons, shows punctate expression throughout the cell body, nucleus and dendrites. Not detected in axons. {ECO:0000250|UniProtKB:Q08274, ECO:0000269|PubMed:33844468}.
uniprot
proteins