NHERF4
entrez
79849
canonical
uniprot
Q86UT5
canonical
ensembl
ENSG00000172367
resolver
ensp
ENSP00000327107
resolver
ensp
ENSP00000347742
resolver
ensp
ENSP00000431164
resolver
ensp
ENSP00000434559
resolver
enst
ENST00000525131
resolver
genesymbol
NHERF4
resolver
genesymbol_syn
IKEPP
resolver
genesymbol_syn
PDZD3
resolver
genesymbol_syn
PDZK2
resolver
hgnc
HGNC:19891
resolver
uniprot
E9PPZ1
resolver
uniprot
Q8N6R4
resolver
uniprot
Q8NAW7
resolver
uniprot
Q8NEX7
resolver
uniprot
Q9H5Z3
resolver
uniprot_entry
E9PPZ1_HUMAN
resolver
uniprot_entry
NHRF4_HUMAN
resolver
uniprot_sec
Q8N6R4
resolver
uniprot_sec
Q8NAW7
resolver
uniprot_sec
Q8NEX7
resolver
uniprot_sec
Q9H5Z3
resolver
amino_acid_sequence
MVTPSPPGNHSLSLEAPRLHTASDLLGNHSLGLPLITALVGSRDRRGRVFSPVPVPLPTNPTTQHPTRQKLPSTLSGHRVCQAHGEPVLGLCPLLPLFCCPPHPPDPWSLERPRFCLLSKEEGKSFGFHLQQELGRAGHVVCRVDPGTSAQRQGLQEGDRILAVNNDVVEHEDYAVVVRRIRASSPRVLLTVLARHAHDVARAQLGEDAHLCPTLGPGVRPRLCHIVKDEGGFGFSVTHGNQGPFWLVLSTGGAAERAGVPPGARLLEVNGVSVEKFTHNQLTRKLWQSGQQVTLLVAGPEVEEQCRQLGLPLAAPLAEGWALPTKPRCLHLEKGPQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAGMQAGDRLVAVAGESVEGLGHEETVSRIQGQGSCVSLTVVDPEADRFFSMVRLSPLLFLENTEAPASPRGSSSASLVETEDPSLEDTSVPSVPLGSRQCFLYPGPGGSYGFRLSCVASGPRLFISQVTPGGSAARAGLQVGDVILEVNGYPVGGQNDLERLQQLPEAEPPLCLKLAARSLRGLEAWIPPGAAEDWALASDLL
uniprot
proteins
function
FUNCTION: Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (PubMed:11950846). Stimulates SLC9A3 activity in the presence of elevated calcium ions (PubMed:19088451). {ECO:0000269|PubMed:11950846, ECO:0000269|PubMed:19088451}.
uniprot
proteins
mass_dalton
61032
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-395 negatively regulates its interaction with SLC26A3. {ECO:0000250|UniProtKB:Q99MJ6}.
uniprot
proteins
pubmed
11950846
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
19088451
uniprot
proteins
pubmed
22627094
uniprot
proteins
pubmed
26756164
uniprot
proteins
sequence_length
571
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11950846, ECO:0000269|PubMed:19088451, ECO:0000269|PubMed:22627094}; Peripheral membrane protein {ECO:0000269|PubMed:11950846, ECO:0000269|PubMed:19088451}. Cytoplasm {ECO:0000269|PubMed:19088451}. Note=Preferentially accumulates at the apical surface and ileal brush border of intestinal epithelial cells (PubMed:11950846, PubMed:19088451). {ECO:0000269|PubMed:11950846, ECO:0000269|PubMed:19088451}.
uniprot
proteins