ARHGAP44
entrez
9912
canonical
uniprot
Q17R89
canonical
ensembl
ENSG00000006740
resolver
ensp
ENSP00000262444
resolver
ensp
ENSP00000342566
resolver
ensp
ENSP00000368994
resolver
ensp
ENSP00000530071
resolver
ensp
ENSP00000530072
resolver
ensp
ENSP00000530074
resolver
ensp
ENSP00000666151
resolver
enst
ENST00000262444
resolver
genesymbol
ARHGAP44
resolver
genesymbol_syn
KIAA0672
resolver
genesymbol_syn
RICH2
resolver
hgnc
HGNC:29096
resolver
uniprot
A6NCP5
resolver
uniprot
A8MQB2
resolver
uniprot
E7ERK8
resolver
uniprot
O75160
resolver
uniprot
Q7Z5Z7
resolver
uniprot
Q9Y4Q4
resolver
uniprot_entry
E7ERK8_HUMAN
resolver
uniprot_entry
RHG44_HUMAN
resolver
uniprot_sec
A6NCP5
resolver
uniprot_sec
A8MQB2
resolver
uniprot_sec
O75160
resolver
uniprot_sec
Q7Z5Z7
resolver
uniprot_sec
Q9Y4Q4
resolver
amino_acid_sequence
MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGAEADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDKLAQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQIKAQQEAWVEKPSFGKPLEEHLTISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLKKLKAALDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNVQEQDKKLQALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQAEGNITEMMTTVSLQIVGIIEPIIQHADWFFPGEIEFNITGNYGSPVHVNHNANYSSMPSPDMDPADRRQPEQARRPLSVATDNMMLEFYKKDGLRKIQSMGVRVMDTNWVARRGSSAGRKVSCAPPSMQPPAPPAELAAPLPSPLPEQPLDSPAAPALSPSGLGLQPGPERTSTTKSKELSPGSAQKGSPGSSQGTACAGTQPGAQPGAQPGASPSPSQPPADQSPHTLRKVSKKLAPIPPKVPFGQPGAMADQSAGQPSPVSLSPTPPSTPSPYGLSYPQGYSLASGQLSPAAAPPLASPSVFTSTLSKSRPTPKPRQRPTLPPPQPPTVNLSASSPQSTEAPMLDGMSPGESMSTDLVHFDIPSIHIELGSTLRLSPLEHMRRHSVTDKRDSEEESESTAL
uniprot
proteins
function
FUNCTION: GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1 (PubMed:11431473). In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity (By similarity). Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation (By similarity). In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation (By similarity). {ECO:0000250|UniProtKB:F1LQX4, ECO:0000250|UniProtKB:Q5SSM3, ECO:0000269|PubMed:11431473}.
uniprot
proteins
mass_dalton
89247
uniprot
proteins
pubmed
11431473
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19273615
uniprot
proteins
pubmed
9734811
uniprot
proteins
sequence_length
818
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q5SSM3}. Recycling endosome {ECO:0000250|UniProtKB:Q5SSM3}. Presynapse {ECO:0000250|UniProtKB:Q5SSM3}. Cell projection, dendrite {ECO:0000250|UniProtKB:F1LQX4}. Note=In CA1 hippocampal synapses, detected at both presynaptic and postsynaptic sites (By similarity). Located in convoluted dendritic plasma membrane sections enriched in polymerized actin and myosin (patches) along dendrites where often emerge filopodia (By similarity). {ECO:0000250|UniProtKB:F1LQX4, ECO:0000250|UniProtKB:Q5SSM3}.
uniprot
proteins