Man2a1
entrez
25478
canonical
uniprot
P28494
canonical
ensembl
ENSRNOG00000015439
resolver
ensembl
ENSRNOG00060001663
resolver
ensembl
ENSRNOG00065019149
resolver
ensp
ENSRNOP00000020767
resolver
ensp
ENSRNOP00060001650
resolver
ensp
ENSRNOP00065025721
resolver
enst
ENSRNOT00000020767
resolver
enst
ENSRNOT00060002527
resolver
enst
ENSRNOT00065032212
resolver
genesymbol
Man2a1
resolver
genesymbol_syn
Mana2
resolver
uniprot
G3V7Y9
resolver
uniprot_entry
MA2A1_RAT
resolver
uniprot_sec
G3V7Y9
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by swainsonine. {ECO:0000269|PubMed:1885615}.
uniprot
proteins
amino_acid_sequence
MKLSRQFTVFGSAIFCVVIFSLYLMLDRGHLDYPRGPRQEGSFPQGQLSILQEKIDHLERLLAENNEIISNIRDSVINLSESVEDGPRGPAGNASQGSAHLHSAQLALQADPKDCLFASQSGNQHRDVQMLDVYDLIPFDNPDGGVWKQGFDIKYEADEWDREPLQVFVVPHSHNDPGWLKTFNDYFRDKTQYIFNNMVLKLKEDSSRKFIWSEISYLAKWWDIIDNPKKEAVKSLLQNGQLEIVTGGWVMADEATTHYFALIDQLIEGHQWLEKNLGVKPRSGWAIDPFGHSPTMTYLLKRAGFSHMLIQRVHYSVKKHFSLQKTLEFFWRQNWDLGSTTDILCHMMPFYSYDIPHTCGPDPKICCQFDFKRLPGGRYGCPWGVPPEAISPGNVQSRAQMLLDQYRKKSKLFRTKVLLAPLGDDFRFSEYTEWDLQYRNYEQLFSYMNSQPHLKVKIQFGTLSDYFDALEKSVAAEKKGGQSVFPALSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMESRLRTAEILYHLALKQAQKYKINKFLSSPHYTTLTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFQSLNSLEKIIGDSAFLLILKDKKLYQSDPSKAFLEMDTKQSSQDSLPKKNIIQLSAQEPRYLVVYNPFEQERHSVVSVRVNSATVKVLSDLGKAVEVQVSAVWKDMRTTSQAAYEVAFLAHLPPLGLKVYKILESQSSSSHLADYFLYNNDGQAESGIFHMKNMVDSGDAITIENSFLTLGFDRSGLMEKVRRKEDNKQQELKVQFLWYGTTNKRDKSGAYLFLPDGQGQPYVSLRTPFVRVTRGRIYSDVTCFLEHVTHKVRLYHIQGIEGQSMEVSNIVDIRSVHNREIVMRISSKINNQNRYYTDLNGYQIQPRRTMAKLPLQANVYPMSTMAYIQDAAHRLTLLSAQSLGASSMASGQIEVFMDRRLMQDDNRGLGQGVHDNKITANLFRILLEKRNGMNMEEDKKSPVSYPSLLSHMTSAFLNHPFLPMVLSGQLPSPAIELLSEFRLLQSSLPCDIHLVNLRTIQSKVGKGYSDEAALILHRKVFDCQLSSRAMGLPCSTTQGKMSIPKLFNNFAVESFIPSSLSLMHSPPDAQNTSEVSLSPMEISTSRIRLR
uniprot
proteins
ec_number
3.2.1.114
uniprot
proteins
function
FUNCTION: Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway. {ECO:0000303|PubMed:1885615}.
uniprot
proteins
mass_dalton
131242
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000303|PubMed:1885615}.
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:1885615}.
uniprot
proteins
protein_family
Glycosyl hydrolase 38 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
1885615
uniprot
proteins
pubmed
2246269
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2748583
uniprot
proteins
sequence_length
1148
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:1885615, ECO:0000269|PubMed:2246269, ECO:0000269|PubMed:2748583}; Single-pass type II membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 6..26; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins