CBX3
entrez
11335
canonical
uniprot
Q13185
canonical
ensembl
ENSG00000122565
resolver
ensp
ENSP00000336687
resolver
ensp
ENSP00000379670
resolver
ensp
ENSP00000387348
resolver
ensp
ENSP00000593429
resolver
ensp
ENSP00000593430
resolver
ensp
ENSP00000593431
resolver
ensp
ENSP00000593432
resolver
ensp
ENSP00000593433
resolver
ensp
ENSP00000593434
resolver
ensp
ENSP00000593435
resolver
ensp
ENSP00000593436
resolver
ensp
ENSP00000593437
resolver
ensp
ENSP00000593438
resolver
ensp
ENSP00000593439
resolver
ensp
ENSP00000593441
resolver
ensp
ENSP00000593442
resolver
ensp
ENSP00000593443
resolver
ensp
ENSP00000593444
resolver
ensp
ENSP00000593445
resolver
ensp
ENSP00000633242
resolver
enst
ENST00000337620
resolver
enst
ENST00000396386
resolver
enst
ENST00000409747
resolver
enst
ENST00000923370
resolver
enst
ENST00000923371
resolver
enst
ENST00000923372
resolver
enst
ENST00000923373
resolver
enst
ENST00000923374
resolver
enst
ENST00000923375
resolver
enst
ENST00000923376
resolver
enst
ENST00000923377
resolver
enst
ENST00000923378
resolver
enst
ENST00000923379
resolver
enst
ENST00000923380
resolver
enst
ENST00000923382
resolver
enst
ENST00000923383
resolver
enst
ENST00000923384
resolver
enst
ENST00000923385
resolver
enst
ENST00000923386
resolver
enst
ENST00000963183
resolver
genesymbol
CBX3
resolver
hgnc
HGNC:1553
resolver
uniprot
A0A024RA30
resolver
uniprot
B8ZZ43
resolver
uniprot
Q96CD7
resolver
uniprot
Q99409
resolver
uniprot
Q9BVS3
resolver
uniprot
Q9P0Z6
resolver
uniprot_entry
B8ZZ43_HUMAN
resolver
uniprot_entry
CBX3_HUMAN
resolver
uniprot_sec
A0A024RA30
resolver
uniprot_sec
Q96CD7
resolver
uniprot_sec
Q99409
resolver
uniprot_sec
Q9BVS3
resolver
uniprot_sec
Q9P0Z6
resolver
amino_acid_sequence
MASNKTTLQKMGKKQNGKSKKVEEAEPEEFVVEKVLDRRVVNGKVEYFLKWKGFTDADNTWEPEENLDCPELIEAFLNSQKAGKEKDGTKRKSLSDSESDDSKSKKKRDAADKPRGFARGLDPERIIGATDSSGELMFLMKWKDSDEADLVLAKEANMKCPQIVIAFYEERLTWHSCPEDEAQ
uniprot
proteins
function
FUNCTION: Component of heterochromatin, which recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression (PubMed:11242053). Also recognizes and binds histone H1.4 methylated at 'Lys-26' (H1.4K26me) (PubMed:16127177). Excluded from chromatin when histone H1.4 is Simultaneously methylated at Lys-26 (H1.4K26me) and phosphorylated at Ser-27 (H1.4S27Ph) (PubMed:16127177). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins (PubMed:15502821). Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the methyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1 (By similarity). Mediates the recruitment of NIPBL to sites of DNA damage at double-strand breaks (DSBs) (PubMed:28167679). {ECO:0000250|UniProtKB:P23198, ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:15502821, ECO:0000269|PubMed:16127177, ECO:0000269|PubMed:28167679}.
uniprot
proteins
mass_dalton
20811
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis. {ECO:0000269|PubMed:10460410, ECO:0000269|PubMed:10664448}.
uniprot
proteins
pubmed
10330177
uniprot
proteins
pubmed
10460410
uniprot
proteins
pubmed
10664448
uniprot
proteins
pubmed
11242053
uniprot
proteins
pubmed
12004135
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15502821
uniprot
proteins
pubmed
16127177
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19880879
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20562864
uniprot
proteins
pubmed
20850016
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21346195
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23251473
uniprot
proteins
pubmed
23542155
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25750265
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28167679
uniprot
proteins
pubmed
28977666
uniprot
proteins
pubmed
32051553
uniprot
proteins
pubmed
8663349
uniprot
proteins
pubmed
9169472
uniprot
proteins
pubmed
9636146
uniprot
proteins
pubmed
9864353
uniprot
proteins
sequence_length
183
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28977666}. Note=Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential). {ECO:0000305}.
uniprot
proteins