PAN3
entrez
255967
canonical
uniprot
Q58A45
canonical
ensembl
ENSG00000152520
resolver
ensp
ENSP00000370345
resolver
ensp
ENSP00000382522
resolver
ensp
ENSP00000583253
resolver
genesymbol
PAN3
resolver
hgnc
HGNC:29991
resolver
uniprot
A0N0X1
resolver
uniprot
A1A4Y8
resolver
uniprot
A1A4Y9
resolver
uniprot
B1ALF1
resolver
uniprot
B7Z3W7
resolver
uniprot
Q0D2P2
resolver
uniprot
Q5HYG6
resolver
uniprot
Q5T515
resolver
uniprot
Q5T516
resolver
uniprot
Q5TBA0
resolver
uniprot
Q76E13
resolver
uniprot
Q8NBA6
resolver
uniprot_entry
PAN3_HUMAN
resolver
uniprot_sec
A0N0X1
resolver
uniprot_sec
A1A4Y8
resolver
uniprot_sec
A1A4Y9
resolver
uniprot_sec
B1ALF1
resolver
uniprot_sec
B7Z3W7
resolver
uniprot_sec
Q0D2P2
resolver
uniprot_sec
Q5HYG6
resolver
uniprot_sec
Q5T515
resolver
uniprot_sec
Q5T516
resolver
uniprot_sec
Q5TBA0
resolver
uniprot_sec
Q76E13
resolver
uniprot_sec
Q8NBA6
resolver
amino_acid_sequence
MNSGGGLPPPSAAASPSSSSLAAAVAVVAPPGVGGVPGGAAVGVKLKYCRYYAKDKTCFYGEECQFLHEDPAAGAAPGLGLHSNSVPLALAGAPVAGFPPGAVAGGGAGPPPGPKKPDLGDPGTGAAAGGGGSSGGLDGPRLAIPGMDGGALTDTSLTDSYFSTSFIGVNGFGSPVETKYPLMQRMTNSSSSPSLLNDSAKPYSAHDPLTSPASSLFNDFGALNISQRRKPRKYRLGMLEERLVPMGSKARKAKNPIGCLADRCKSGVPINMVWWNRVTENNLQTPNPTASEFIPKGGSTSRLSNVSQSNMSAFSQVFSHPSMGSPATAGLAPGMSLSAGSSPLHSPKITPHTSPAPRRRSHTPNPASYMVPSSASTSVNNPVSQTPSSGQVIQKETVGGTTYFYTDTTPAPLTGMVFPNYHIYPPTAPHVAYMQPKANAPSFFMADELRQELINRHLITMAQIDQADMPAVPTEVDSYHSLFPLEPLPPPNRIQKSSNFGYITSCYKAVNSKDDLPYCLRRIHGFRLVNTKCMVLVDMWKKIQHSNIVTLREVFTTKAFAEPSLVFAYDFHAGGETMMSRHFNDPNADAYFTKRKWGQHEGPLPRQHAGLLPESLIWAYIVQLSSALRTIHTAGLACRVMDPTKILITGKTRLRVNCVGVFDVLTFDNSQNNNPLALMAQYQQADLISLGKVVLALACNSLAGIQRENLQKAMELVTINYSSDLKNLILYLLTDQNRMRSVNDIMPMIGARFYTQLDAAQMRNDVIEEDLAKEVQNGRLFRLLAKLGTINERPEFQKDPTWSETGDRYLLKLFRDHLFHQVTEAGAPWIDLSHIISCLNKLDAGVPEKISLISRDEKSVLVVTYSDLKRCFENTFQELIAAANGQL
uniprot
proteins
function
FUNCTION: Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenylation-dependent mRNA decapping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins. {ECO:0000255|HAMAP-Rule:MF_03181, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:23932717}.; FUNCTION: [Isoform 1]: Decreases PAN2-mediated deadenylation, possibly by preventing progression into the second CCR4-NOT mediated stage of biphasic deadenylation. Has a significant effect on mRNA stability, generally stabilizing a subset of the transcriptome. Stabilizes mRNAs degraded by the AU-rich element (ARE)-mediated mRNA decay pathway but promotes degradation of mRNAs by the microRNA-mediated pathway (PubMed:28559491). Its activity influences mRNP remodeling, specifically reducing formation of a subset of P-bodies containing GW220, an isoform of TNRC6A (PubMed:28559491). {ECO:0000269|PubMed:28559491}.; FUNCTION: [Isoform 3]: Enhances PAN2 deadenylase activity and has an extensive effect on mRNA stability, generally enhancing mRNA decay across the transcriptome by multiple pathways, including the AU-rich element (ARE)-mediated pathway, microRNA-mediated pathway and the nonsense-mediated pathway (NMD) (PubMed:28559491). Its activity is required for efficient P-body formation (PubMed:28559491). May be involved in regulating mRNAs of genes involved in cell cycle progression and cell proliferation (PubMed:28559491). {ECO:0000269|PubMed:28559491}.
uniprot
proteins
mass_dalton
95613
uniprot
proteins
mutagenesis
MUTAGEN 203; /note="Y->A: Reduces interaction with polyadenylate-binding protein."; /evidence="ECO:0000269|PubMed:18056425"; MUTAGEN 293; /note="F->A: Reduces interaction with polyadenylate-binding protein."; /evidence="ECO:0000269|PubMed:17595167, ECO:0000269|PubMed:18056425
uniprot
proteins
protein_family
PAN3 family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
14583602
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17595167
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18056425
uniprot
proteins
pubmed
18625844
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21981923
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23932717
uniprot
proteins
pubmed
28559491
uniprot
proteins
pubmed
31570513
uniprot
proteins
sequence_length
887
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000255|HAMAP-Rule:MF_03181, ECO:0000269|PubMed:14583602, ECO:0000269|PubMed:18625844}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Nucleus {ECO:0000269|PubMed:28559491}. Note=Shuttles between cytoplasm and nucleus. {ECO:0000269|PubMed:28559491}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:28559491}.
uniprot
proteins