Icos
entrez
54167
canonical
uniprot
Q9WVS0
canonical
ensembl
ENSMUSG00000026009
resolver
ensp
ENSMUSP00000099891
resolver
enst
ENSMUST00000102827
resolver
genesymbol
Icos
resolver
genesymbol_syn
Ailim
resolver
uniprot
Q3V3X2
resolver
uniprot
Q5SUZ7
resolver
uniprot
Q9JL17
resolver
uniprot_entry
ICOS_MOUSE
resolver
uniprot_entry
Q3V3X2_MOUSE
resolver
uniprot_entry
Q5SUZ7_MOUSE
resolver
uniprot_sec
Q9JL17
resolver
amino_acid_sequence
MKPYFCRVFVFCFLIRLLTGEINGSADHRMFSFHNGGVQISCKYPETVQQLKMRLFREREVLCELTKTKGSGNAVSIKNPMLCLYHLSNNSVSFFLNNPDSSQGSYYFCSLSIFDPPPFQERNLSGGYLHIYESQLCCQLKLWLPVGCAAFVVVLLFGCILIIWFSKKKYGSSVHDPNSEYMFMAAVNTNKKSRLAGVTS
uniprot
proteins
function
FUNCTION: Stimulatory receptor expressed in activated or antigen-experienced T-cells that plays an important role in the immune response (PubMed:11343123). Upon binding to its ligand ICOSL expressed on antigen presenting cells (APCs), delivers costimulatory signals that enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines including IL10, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells (PubMed:10657606). Also acts as a costimulatory receptor critical for the differentiation of T follicular regulatory cells upon immune challenges such as viral infection (PubMed:36754569). Mechanistically, potentiates TCR-induced calcium flux by augmenting PLCG1 activation and actin remodeling (PubMed:27693916). In addition, activates PI3K signaling pathways independently of calcium flux (PubMed:19915142, PubMed:27693916). Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (PubMed:11343122). {ECO:0000269|PubMed:10617205, ECO:0000269|PubMed:10657606, ECO:0000269|PubMed:11343122, ECO:0000269|PubMed:11343123, ECO:0000269|PubMed:19915142, ECO:0000269|PubMed:27693916}.
uniprot
proteins
mass_dalton
22709
uniprot
proteins
mutagenesis
MUTAGEN 170; /note="Y->F: Substantial decrease in calcium flux."; /evidence="ECO:0000269|PubMed:27693916"; MUTAGEN 181; /note="Y->F: Selectively abrogates PI3K-dependent signaling pathways AKT and ERK without affecting calcium signaling."; /evidence="ECO:0000269|PubMed:19915142, ECO:0000269|PubMed:27693916
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:10760791}.
uniprot
proteins
pubmed
10617205
uniprot
proteins
pubmed
10657606
uniprot
proteins
pubmed
10760791
uniprot
proteins
pubmed
11006126
uniprot
proteins
pubmed
11343122
uniprot
proteins
pubmed
11343123
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19915142
uniprot
proteins
pubmed
27693916
uniprot
proteins
pubmed
36754569
uniprot
proteins
sequence_length
200
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9Y6W8}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 145..165; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins