Pea15
entrez
18611
canonical
uniprot
Q62048
canonical
ensembl
ENSMUSG00000013698
resolver
ensp
ENSMUSP00000013842
resolver
ensp
ENSMUSP00000106878
resolver
ensp
ENSMUSP00000195368
resolver
ensp
ENSMUSP00000195375
resolver
genesymbol
Pea15
resolver
genesymbol_syn
Pea15a
resolver
uniprot
Q3U5N7
resolver
uniprot_entry
PEA15_MOUSE
resolver
uniprot_sec
Q3U5N7
resolver
amino_acid_sequence
MAEYGTLLQDLTNNITLEDLEQLKSACKEDIPSEKSEEITTGSAWFSFLESHNKLDKDNLSYIEHIFEISRRPDLLTMVVDYRTRVLKISEEEELDTKLTRIPSAKKYKDIIRQPSEEEIIKLAPPPKKA
uniprot
proteins
function
FUNCTION: Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface (By similarity). {ECO:0000250, ECO:0000269|PubMed:10588860}.
uniprot
proteins
mass_dalton
15054
uniprot
proteins
mutagenesis
MUTAGEN 104; /note="S->A: Abolishes inhibitory effect on FAS-mediated apoptosis. Does not change effect on TNFRSF1A-mediated apoptosis."; /evidence="ECO:0000269|PubMed:10588860"; MUTAGEN 116; /note="S->A: Abolishes inhibitory effect on FAS-mediated apoptosis. Does not change effect on TNFRSF1A-mediated apoptosis."; /evidence="ECO:0000269|PubMed:10588860
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by protein kinase C and calcium-calmodulin-dependent protein kinase. These phosphorylation events are modulated by neurotransmitters or hormones. {ECO:0000269|PubMed:10588860}.
uniprot
proteins
pubmed
10588860
uniprot
proteins
pubmed
10926929
uniprot
proteins
pubmed
11210189
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8662970
uniprot
proteins
sequence_length
130
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10926929}. Note=Associated with microtubules.
uniprot
proteins