TSPAN33
entrez
340348
canonical
uniprot
Q86UF1
canonical
ensembl
ENSG00000158457
resolver
ensp
ENSP00000483872
resolver
ensp
ENSP00000573634
resolver
enst
ENST00000486685
resolver
genesymbol
TSPAN33
resolver
genesymbol_syn
PEN
resolver
hgnc
HGNC:28743
resolver
uniprot_entry
TSN33_HUMAN
resolver
amino_acid_sequence
MARRPRAPAASGEEFSFVSPLVKYLLFFFNMLFWVISMVMVAVGVYARLMKHAEAALACLAVDPAILLIVVGVLMFLLTFCGCIGSLRENICLLQTFSLCLTAVFLLQLAAGILGFVFSDKARGKVSEIINNAIVHYRDDLDLQNLIDFGQKKFSCCGGISYKDWSQNMYFNCSEDNPSRERCSVPYSCCLPTPDQAVINTMCGQGMQAFDYLEASKVIYTNGCIDKLVNWIHSNLFLLGGVALGLAIPQLVGILLSQILVNQIKDQIKLQLYNQQHRADPWY
uniprot
proteins
function
FUNCTION: Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates (PubMed:26686862, PubMed:30463011, PubMed:37516108). Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (PubMed:26686862). Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7 (PubMed:30463011). {ECO:0000250|UniProtKB:Q8R3S2, ECO:0000269|PubMed:26686862, ECO:0000269|PubMed:30463011, ECO:0000269|PubMed:37516108}.
uniprot
proteins
mass_dalton
31538
uniprot
proteins
protein_family
Tetraspanin (TM4SF) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16213355
uniprot
proteins
pubmed
17158226
uniprot
proteins
pubmed
26686862
uniprot
proteins
pubmed
30463011
uniprot
proteins
pubmed
37516108
uniprot
proteins
sequence_length
283
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26686862}; Multi-pass membrane protein {ECO:0000305}. Cell junction, adherens junction {ECO:0000269|PubMed:30463011}. Cytoplasm {ECO:0000269|PubMed:30463011}. Note=Is localized to zonula adherens by PLEKHA7 by a PDZD11-dependent interaction. {ECO:0000269|PubMed:30463011}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..45; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 65..85; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 97..117; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 236..256; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins