DKK1
entrez
22943
canonical
uniprot
O94907
canonical
ensembl
ENSG00000107984
resolver
ensp
ENSP00000363081
resolver
enst
ENST00000373970
resolver
genesymbol
DKK1
resolver
hgnc
HGNC:2891
resolver
uniprot
B2RC19
resolver
uniprot
I1W660
resolver
uniprot_entry
DKK1_HUMAN
resolver
uniprot_entry
I1W660_HUMAN
resolver
uniprot_sec
B2RC19
resolver
amino_acid_sequence
MMALGAAGATRVFVAMVAAALGGHPLLGVSATLNSVLNSNAIKNLPPPLGGAAGHPGSAVSAAPGILYPGGNKYQTIDNYQPYPCAEDEECGTDEYCASPTRGGDAGVQICLACRKRRKRCMRHAMCCPGNYCKNGICVSSDQNHFRGEIEETITESFGNDHSTLDGYSRRTTLSSKMYHTKGQEGSVCLRSSDCASGLCCARHFWSKICKPVLKEGQVCTKHRRKGSHGLEIFQRCYCGEGLSCRIQKDHHQASNSSRLHTCQRH
uniprot
proteins
function
FUNCTION: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:22000856). DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (PubMed:17143291). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (By similarity). {ECO:0000250|UniProtKB:O54908, ECO:0000269|PubMed:22000856, ECO:0000303|PubMed:17143291}.
uniprot
proteins
mass_dalton
28672
uniprot
proteins
protein_family
Dickkopf family
uniprot
proteins
pubmed
10383463
uniprot
proteins
pubmed
10570958
uniprot
proteins
pubmed
10965128
uniprot
proteins
pubmed
11448771
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17143291
uniprot
proteins
pubmed
17804805
uniprot
proteins
pubmed
19746449
uniprot
proteins
pubmed
20093360
uniprot
proteins
pubmed
21805521
uniprot
proteins
pubmed
22000856
uniprot
proteins
pubmed
27524201
uniprot
proteins
sequence_length
266
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins