FOXP2
entrez
93986
canonical
uniprot
O15409
canonical
ensembl
ENSG00000128573
resolver
ensp
ENSP00000265436
resolver
ensp
ENSP00000353367
resolver
ensp
ENSP00000375084
resolver
ensp
ENSP00000385069
resolver
ensp
ENSP00000386200
resolver
ensp
ENSP00000571824
resolver
enst
ENST00000390668
resolver
genesymbol
FOXP2
resolver
genesymbol_syn
CAGH44
resolver
genesymbol_syn
TNRC10
resolver
hgnc
HGNC:13875
resolver
uniprot
A0AUV6
resolver
uniprot
A4D0U8
resolver
uniprot
A6NNW4
resolver
uniprot
B4DLD9
resolver
uniprot
B7ZLK5
resolver
uniprot
F8W8A8
resolver
uniprot
Q6ZND1
resolver
uniprot
Q75MJ3
resolver
uniprot
Q8IZE0
resolver
uniprot
Q8N0W2
resolver
uniprot
Q8N6B5
resolver
uniprot
Q8N6B6
resolver
uniprot
Q8N6B7
resolver
uniprot
Q8N6B8
resolver
uniprot
Q8NFQ1
resolver
uniprot
Q8NFQ2
resolver
uniprot
Q8NFQ3
resolver
uniprot
Q8NFQ4
resolver
uniprot
Q8TD74
resolver
uniprot
X5D2H2
resolver
uniprot_entry
B7ZLK5_HUMAN
resolver
uniprot_entry
F8W8A8_HUMAN
resolver
uniprot_entry
FOXP2_HUMAN
resolver
uniprot_entry
Q8N6B5_HUMAN
resolver
uniprot_entry
Q8N6B6_HUMAN
resolver
uniprot_sec
A0AUV6
resolver
uniprot_sec
A4D0U8
resolver
uniprot_sec
A6NNW4
resolver
uniprot_sec
B4DLD9
resolver
uniprot_sec
Q6ZND1
resolver
uniprot_sec
Q75MJ3
resolver
uniprot_sec
Q8IZE0
resolver
uniprot_sec
Q8N0W2
resolver
uniprot_sec
Q8N6B7
resolver
uniprot_sec
Q8N6B8
resolver
uniprot_sec
Q8NFQ1
resolver
uniprot_sec
Q8NFQ2
resolver
uniprot_sec
Q8NFQ3
resolver
uniprot_sec
Q8NFQ4
resolver
uniprot_sec
Q8TD74
resolver
uniprot_sec
X5D2H2
resolver
amino_acid_sequence
MMQESATETISNSSMNQNGMSTLSSQLDAGSRDGRSSGDTSSEVSTVELLHLQQQQALQAARQLLLQQQTSGLKSPKSSDKQRPLQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQQLWKEVTGVHSMEDNGIKHGGLDLTTNNSSSTTSSNTSKASPPITHHSIVNGQSSVLSARRDSSSHEETGASHTLYGHGVCKWPGCESICEDFGQFLKHLNNEHALDDRSTAQCRVQMQVVQQLEIQLSKERERLQAMMTHLHMRPSEPKPSPKPLNLVSSVTMSKNMLETSPQSLPQTPTTPTAPVTPITQGPSVITPASVPNVGAIRRRHSDKYNIPMSSEIAPNYEFYKNADVRPPFTYATLIRQAIMESSDRQLTLNEIYSWFTRTFAYFRRNAATWKNAVRHNLSLHKCFVRVENVKGAVWTVDEVEYQKRRSQKITGSPTLVKNIPTSLGYGAALNASLQAALAESSLPLLSNPGLINNASSGLLQAVHEDLNGSLDHIDSNGNSSPGCSPQPHIHSIHVKEEPVIAEDEDCPMSLVTTANHSPELEDDREIEEEPLSEDLE
uniprot
proteins
disease_involvement
DISEASE: Speech-language disorder 1 (SPCH1) [MIM:602081]: A disorder characterized by severe orofacial dyspraxia resulting in largely incomprehensible speech. Affected individuals have severe impairment in the selection and sequencing of fine orofacial movements which are necessary for articulation, and deficits in several facets of grammatical skills and language processing, such as the ability to break up words into their constituent phonemes. {ECO:0000269|PubMed:11586359, ECO:0000269|PubMed:25232744}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Note=A chromosomal aberration involving FOXP2 is a cause of severe speech and language impairment. Translocation t(5;7)(q22;q31.2).
uniprot
proteins
function
FUNCTION: Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.
uniprot
proteins
mass_dalton
79919
uniprot
proteins
pubmed
11586359
uniprot
proteins
pubmed
12189486
uniprot
proteins
pubmed
12192408
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15056695
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24722188
uniprot
proteins
pubmed
25232744
uniprot
proteins
pubmed
26647308
uniprot
proteins
pubmed
30250039
uniprot
proteins
pubmed
32891193
uniprot
proteins
pubmed
9225980
uniprot
proteins
sequence_length
715
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins