Ntrk2
entrez
25054
canonical
uniprot
Q63604
canonical
ensembl
ENSRNOG00000018839
resolver
ensembl
ENSRNOG00060020051
resolver
ensembl
ENSRNOG00065025416
resolver
ensp
ENSRNOP00000045635
resolver
ensp
ENSRNOP00000070128
resolver
ensp
ENSRNOP00000073595
resolver
enst
ENSRNOT00000082611
resolver
genesymbol
Ntrk2
resolver
genesymbol_syn
Trkb
resolver
uniprot
A0A0G2K5X6
resolver
uniprot
Q63605
resolver
uniprot
Q63606
resolver
uniprot_entry
A0A0G2K5X6_RAT
resolver
uniprot_entry
NTRK2_RAT
resolver
uniprot_sec
Q63605
resolver
uniprot_sec
Q63606
resolver
activity_regulation
ACTIVITY REGULATION: The neuronal activity and the influx of calcium positively regulate the kinase activity and the internalization of the receptor which are both important for active signaling. Regulated by NGFR that may control the internalization of the receptor. NGFR may also stimulate the activation by BDNF compared to NTF3 and NTF4. SH2D1A inhibits the autophosphorylation of the receptor, and alters the recruitment and activation of downstream effectors and signaling cascades. The formation of active receptors dimers able to fully transduce the ligand-mediated signal, may be negatively regulated by the formation of inactive heterodimers with the non-catalytic isoforms. {ECO:0000269|PubMed:16223723}.
uniprot
proteins
amino_acid_sequence
MSPWPRWHGPAMARLWGLCLLVLGFWRASLACPMSCKCSTTRIWCTEPSPGIVAFPRLEPNSIDPENITEILIANQKRLEIINEDDVEAYVGLKNLTIVDSGLKFVAYKAFLKNGNLRHINFTRNKLTSLSRRHFRHLDLSDLILTGNPFTCSCDIMWLKTLQETKSSPDTQDLYCLNESSKNTPLANLQIPNCGLPSARLAAPNLTVEEGKSVTISCSVGGDPLPTLYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVRGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLMAKNEYGKDERQISAHFMGRPGVDYETNPNYPEVLYEDWTTPTDIGDTTNKSNEIPSTDVADQTNREHLSVYAVVVIASVVGFCLLVMLLLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHTRKNIKNIHTLLQNLAKASPVYLDILG
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells. {ECO:0000269|PubMed:10196222, ECO:0000269|PubMed:10985347, ECO:0000269|PubMed:1645620, ECO:0000269|PubMed:9582017}.
uniprot
proteins
mass_dalton
92186
uniprot
proteins
mutagenesis
MUTAGEN 515; /note="Y->F: Loss of interaction with SHC1."; /evidence="ECO:0000269|PubMed:10196222"; MUTAGEN 571; /note="K->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:9582017"; MUTAGEN 701; /note="Y->F: Loss of autophosphorylation and altered interaction with SHC1 and PLCG1; when associated with F-705 and F-706."; /evidence="ECO:0000269|PubMed:9582017"; MUTAGEN 705; /note="Y->F: Loss of autophosphorylation; when associated with F-701 and F-706."; /evidence="ECO:0000269|PubMed:16223723, ECO:0000269|PubMed:9582017"; MUTAGEN 706; /note="Y->F: Loss of autophosphorylation; when associated with F-701 and F-705."; /evidence="ECO:0000269|PubMed:9582017
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Undergoes ligand-mediated autophosphorylation that is required for interaction with SHC1 and PLCG1 and other downstream effectors. Some isoforms are not phosphorylated. {ECO:0000269|PubMed:1645620, ECO:0000269|PubMed:8106527, ECO:0000269|PubMed:8627351}.; PTM: Ubiquitinated. Undergoes polyubiquitination upon activation; regulated by NGFR. Ubiquitination regulates the internalization of the receptor (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Insulin receptor subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
10092678
uniprot
proteins
pubmed
10196222
uniprot
proteins
pubmed
10985347
uniprot
proteins
pubmed
12471037
uniprot
proteins
pubmed
15167895
uniprot
proteins
pubmed
16223723
uniprot
proteins
pubmed
1645620
uniprot
proteins
pubmed
1846020
uniprot
proteins
pubmed
21775604
uniprot
proteins
pubmed
24090084
uniprot
proteins
pubmed
8106527
uniprot
proteins
pubmed
8627351
uniprot
proteins
pubmed
9582017
uniprot
proteins
pubmed
9856458
uniprot
proteins
pubmed
9927421
uniprot
proteins
sequence_length
821
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1645620}; Single-pass type I membrane protein {ECO:0000269|PubMed:1645620}. Endosome membrane {ECO:0000250|UniProtKB:P15209}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P15209}. Early endosome membrane {ECO:0000250|UniProtKB:P15209}. Cell projection, axon {ECO:0000269|PubMed:21775604}. Cell projection, dendrite {ECO:0000269|PubMed:21775604}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:21775604}. Postsynaptic density {ECO:0000250|UniProtKB:P15209}. Note=Internalized to endosomes upon ligand-binding. {ECO:0000250|UniProtKB:P15209}.
uniprot
proteins
transmembrane_region
TRANSMEM 430..453; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins