Myrf
entrez
225908
canonical
uniprot
Q3UR85
canonical
ensembl
ENSMUSG00000036098
resolver
ensp
ENSMUSP00000085329
resolver
ensp
ENSMUSP00000139601
resolver
ensp
ENSMUSP00000284298
resolver
ensp
ENSMUSP00000284300
resolver
ensp
ENSMUSP00000284301
resolver
ensp
ENSMUSP00000331574
resolver
ensp
ENSMUSP00000331575
resolver
genesymbol
Myrf
resolver
genesymbol_syn
Gm1804
resolver
genesymbol_syn
Gm98
resolver
genesymbol_syn
Mrf
resolver
uniprot
B2RXQ7
resolver
uniprot
F8WJJ9
resolver
uniprot
Q3V3K4
resolver
uniprot_entry
MYRF_MOUSE
resolver
uniprot_sec
B2RXQ7
resolver
uniprot_sec
F8WJJ9
resolver
uniprot_sec
Q3V3K4
resolver
amino_acid_sequence
MEVVDETEALQRFFEGHDISGALEPSNIDTSILEEYIGKEDASDLCFPEISAPASTASFPHGPPAIPGSSGLHHLSPPGSGPSPGRHGPLPPPTYGTPLNCNNNNGMGTAPKPFLGGSGPPIKAEPKAPYAPGTLPDSPPDSGSEAYSPQQVNDPHLLRTITPETLCHVGVSSRLEHPPPPPAHLPGPPPPPPPPPHYPVLQRDLYMKAEPPVPPYAAMGPGLVPPELHHTQQTQVLHQLLQQHGAELPPHPSKKRKHSESPPNTLNAQMLNGMIKQEPGTVTALPPHPARAPSPPWPPQGPLSPGTGSLPLSIARAQTPPWHPPGAPSPGLLQDSDSLSGSYLDPNYQSIKWQPHQQNKWATLYDANYKELPMLTYRVDADKGFNFSVGDDAFVCQKKNHFQVTVYIGMLGEPKYVKTPEGLKPLDCFYLKLHGVKLEALNQSINIEQSQSDRSKRPFNPVTVNLPPEQVTKVTVGRLHFSETTANNMRKKGKPNPDQRYFMLVVALQAHAQNQNYTLAAQISERIIVRASNPGQFESDSDVLWQRAQLPDTVFHHGRVGINTDRPDEALVVHGNVKVMGSLMHPSDLRAKEHVQEVDTTEQLKRISRMRLVHYRYKPEFAASAGIEATAPETGVIAQEVKEILPEAVKDTGDVVFANGKTIENFLVVNKERIFMENVGAVKELCKLTDNLETRIDELERWSHKLAKLRRLDSLKSTGSSGAFSHAGSQFSRAGSVPHKKRPPKLANKSSPAVPDQACISQRFLQGTIIALVVVMAFSVVSMSTLYVLSLRSEEDLVDADGSLAVSTSCLLALLRPQDPGGSEAMCPWSSQSFGTTQLRQSSMTTGLPGTQPSLLLVTKSASGPALRALDLCSSQPCPIVCCSPPVSSPATDPALGPTLTPTPSPSSNPKHSGPGQMAPLPVTNIRAKSWGISANGISYSKHSKSLEPLASPVVPFPGGQSKTKNSPSFNLQSRARRGAPQPSPSPAQFTQTQGQLDPAPSLTSIQLLENSMPITSQYCVPEGACRLGNFTYHIPVSSSTPLHLSLTLQMNSSTPVSVVLCSLTSEEEPCEEGGFLQRFHPHQDTQGTSHQWPVTILSFREFTYHFRVTLLGQANCSSEAIVQPATDYYFHFYRLCD
uniprot
proteins
ec_number
3.4.-.-
uniprot
proteins
function
FUNCTION: [Myelin regulatory factor]: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes. {ECO:0000269|PubMed:23966833, ECO:0000269|PubMed:28623291}.; FUNCTION: [Myelin regulatory factor, C-terminal]: Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage. {ECO:0000269|PubMed:23966833}.; FUNCTION: [Myelin regulatory factor, N-terminal]: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination (PubMed:19596243, PubMed:22956843, PubMed:23966833, PubMed:24204311, PubMed:27532821). Specifically recognizes and binds DNA sequence 5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype (PubMed:19596243, PubMed:22956843, PubMed:23966833). {ECO:0000269|PubMed:19596243, ECO:0000269|PubMed:22956843, ECO:0000269|PubMed:23966833, ECO:0000269|PubMed:24204311, ECO:0000269|PubMed:27532821}.
uniprot
proteins
mass_dalton
123288
uniprot
proteins
mutagenesis
MUTAGEN 254..256; /note="KKR->AAA: Abolishes nuclear localization."; MUTAGEN 384; /note="G->R: Does not affect subcellular location. Impaired DNA-binding."; /evidence="ECO:0000269|PubMed:28441531"; MUTAGEN 399; /note="K->A: Abolishes DNA-binding."; /evidence="ECO:0000269|PubMed:23966833"; MUTAGEN 439..441; /note="Missing: Loss of trimerization; when associated with R-469."; /evidence="ECO:0000269|PubMed:28623291"; MUTAGEN 454; /note="R->A: Abolishes DNA-binding."; /evidence="ECO:0000269|PubMed:23966833"; MUTAGEN 469; /note="E->R: Loss of trimerization; when associated with 439-E--L-441 DEL."; /evidence="ECO:0000269|PubMed:28623291"; MUTAGEN 478; /note="R->A: Abolishes DNA-binding."; /evidence="ECO:0000269|PubMed:23966833"; MUTAGEN 587; /note="S->A: Prevents autocatalytic cleavage and generation of Myelin regulatory factor, N-terminal part."; /evidence="ECO:0000269|PubMed:23966833, ECO:0000269|PubMed:28623291"; MUTAGEN 587; /note="S->C: Does not affect autocatalytic cleavage and generation of Myelin regulatory factor, N-terminal part."; /evidence="ECO:0000269|PubMed:23966833"; MUTAGEN 592; /note="K->H,R,M: Prevents autocatalytic cleavage and generation of Myelin regulatory factor, N-terminal part."; /evidence="ECO:0000269|PubMed:23966833
uniprot
proteins
post_translational_modification
PTM: [Myelin regulatory factor, C-terminal]: Glycosylated. {ECO:0000250|UniProtKB:Q9Y2G1}.; PTM: [Myelin regulatory factor]: Follows autocatalytic cleavage via the peptidase S74 domain. Autoprocessing is apparently constitutive and is essential for transcriptional activity (PubMed:23966833, PubMed:28623291, PubMed:30249802). Autocatalytic cleavage is inhibited by interaction with TMEM98 (PubMed:30249802). {ECO:0000269|PubMed:23966833, ECO:0000269|PubMed:28623291, ECO:0000269|PubMed:30249802}.
uniprot
proteins
protein_family
MRF family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19596243
uniprot
proteins
pubmed
22956843
uniprot
proteins
pubmed
23966833
uniprot
proteins
pubmed
24204311
uniprot
proteins
pubmed
27532821
uniprot
proteins
pubmed
28441531
uniprot
proteins
pubmed
28623291
uniprot
proteins
pubmed
30249802
uniprot
proteins
pubmed
31048900
uniprot
proteins
sequence_length
1138
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Myelin regulatory factor]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23966833, ECO:0000269|PubMed:30249802}; Single-pass membrane protein.; SUBCELLULAR LOCATION: [Myelin regulatory factor, N-terminal]: Nucleus {ECO:0000269|PubMed:23966833, ECO:0000269|PubMed:28441531, ECO:0000269|PubMed:30249802}. Cytoplasm {ECO:0000269|PubMed:23966833}. Note=Translocates from the cytoplasm to the nucleus upon autocatalytic cleavage. {ECO:0000269|PubMed:23966833, ECO:0000269|PubMed:30249802}.; SUBCELLULAR LOCATION: [Myelin regulatory factor, C-terminal]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23966833, ECO:0000269|PubMed:30249802}; Single-pass membrane protein {ECO:0000269|PubMed:23966833}.
uniprot
proteins
transmembrane_region
TRANSMEM 769..789; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins