Mefv
entrez
54483
canonical
uniprot
Q9JJ26
canonical
ensembl
ENSMUSG00000022534
resolver
ensp
ENSMUSP00000023180
resolver
ensp
ENSMUSP00000097795
resolver
ensp
ENSMUSP00000154892
resolver
enst
ENSMUST00000023180
resolver
enst
ENSMUST00000100222
resolver
enst
ENSMUST00000229725
resolver
genesymbol
Mefv
resolver
uniprot
A0A2R8VJS0
resolver
uniprot
E9QN30
resolver
uniprot
F6ZU71
resolver
uniprot
Q32MT0
resolver
uniprot
Q32MT1
resolver
uniprot_entry
A0A2R8VJS0_MOUSE
resolver
uniprot_entry
F6ZU71_MOUSE
resolver
uniprot_entry
MEFV_MOUSE
resolver
uniprot_entry
Q32MT0_MOUSE
resolver
uniprot_entry
Q32MT1_MOUSE
resolver
uniprot_sec
E9QN30
resolver
amino_acid_sequence
MAKTLGDHLLNTLEELLPYDFEKFKFKLQNTSLEKGHSKIPRGHMQMARPVKLASLLITYYGEEYAVRLTLQILRATNQRQLAEELRKATGTEHLIEENRVGGSVQSSVENKAKSVKVPDVPEGDGTQQNNDESDTLPSSQAEVGKGPQKKSLTKRKDQRGPESLDSQTKPWTRSTAPLYRRTQGTQSPGDKESTASAQLRRNVSSAGRLQGLYNNAPGRRESKKAEVYVYLPSGKKRPRSLEITTYSREGEPPNSEVLPTQEETRNGSLIRMRTATLNGRTTGALEKGTGIPEHSMVLDEKTFRNMSSKTSLIGEERCPTSWTENGNGSPETTESSGETAGSILSDPEVPLSLCEKPAKTPEDPASLGQAACEGRSQDKAVCPLCHTQEGDLRGDTCVQSSCSCSIAPGDPKASGRCSICFQCQGLLARKSCEAQSPQSLPQCPRHMKQVLLLFCEDHREPICLICRLSLEHQGHRVRPIEEAALEYKEQIREQLERLREMRGYVEEHRLQGDKKTDDFLKQTEIQKQKISCPLEKLYQLLEKQEQLFVTWLQELSQTISKVRETYYTRVSLLDEMIEELEAKQDQPEWDLMQDIGITLHRAKMMSASELLDTPPGVKEKLHLLYQKSKSVEKNMQCFSEMLSSEMAFSASDVAKWEGRQPSATQVQGLVPTVHLKCDGAHTQDCDVVFYPEREAGGSEPKDYLHPQPAQDTPELHEIHSRNNKRKFKSFLKWKPSFSRTDWRLRTCCYRDLDQAAAHPNLIFSMI
uniprot
proteins
function
FUNCTION: Involved in the regulation of innate immunity and the inflammatory response in response to IFNG/IFN-gamma (PubMed:34471287). Organizes autophagic machinery by serving as a platform for the assembly of ULK1, Beclin 1/BECN1, ATG16L1, and ATG8 family members and recognizes specific autophagy targets, thus coordinating target recognition with assembly of the autophagic apparatus and initiation of autophagy (By similarity). Acts as an autophagy receptor for the degradation of several inflammasome components, including CASP1, NLRP1 and NLRP3, hence preventing excessive IL1B- and IL18-mediated inflammation (By similarity). However, it can also have a positive effect in the inflammatory pathway, acting as an innate immune sensor that triggers PYCARD/ASC specks formation, caspase-1 activation, and IL1B and IL18 production (By similarity). Together with AIM2, also acts as a mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, in response to bacterial infection (PubMed:34471287). It is required for PSTPIP1-induced PYCARD/ASC oligomerization and inflammasome formation (By similarity). Recruits PSTPIP1 to inflammasomes, and is required for PSTPIP1 oligomerization (By similarity). {ECO:0000250|UniProtKB:O15553, ECO:0000269|PubMed:34471287}.
uniprot
proteins
mass_dalton
86409
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-241 is required for the interaction with 14-3-3 proteins and down-regulation of pyrin pro-inflammatory activity. {ECO:0000250|UniProtKB:O15553}.; PTM: Degraded along with the delivery of its substrates to autolysosomal compartments (at protein level). {ECO:0000250|UniProtKB:O15553}.
uniprot
proteins
pubmed
10818206
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23226472
uniprot
proteins
pubmed
34471287
uniprot
proteins
sequence_length
767
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O15553}. Cell projection, ruffle {ECO:0000250|UniProtKB:O15553}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:O15553}. Cytoplasm {ECO:0000250|UniProtKB:O15553}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:O15553}. Nucleus {ECO:0000250|UniProtKB:O15553}. Note=Associated with microtubules and with the filamentous actin of perinuclear filaments and peripheral lamellar ruffles. In pre-apoptotic cells, colocalizes with PYCARD/ASC in large specks (pyroptosomes). In migrating monocytes, strongly polarized at the leading edge of the cell where it colocalizes with polymerizing actin and PYCARD/ASC (By similarity). {ECO:0000250|UniProtKB:O15553}.
uniprot
proteins