Cntfr
entrez
12804
canonical
uniprot
O88507
canonical
ensembl
ENSMUSG00000028444
resolver
ensp
ENSMUSP00000100026
resolver
ensp
ENSMUSP00000100027
resolver
ensp
ENSMUSP00000164770
resolver
ensp
ENSMUSP00000164773
resolver
ensp
ENSMUSP00000164774
resolver
ensp
ENSMUSP00000164775
resolver
ensp
ENSMUSP00000164777
resolver
ensp
ENSMUSP00000164778
resolver
enst
ENSMUST00000102961
resolver
enst
ENSMUST00000102962
resolver
genesymbol
Cntfr
resolver
uniprot
Q80T01
resolver
uniprot_entry
CNTFR_MOUSE
resolver
uniprot_sec
Q80T01
resolver
amino_acid_sequence
MAASVPWACCAVLAAAAAAVYTQKHSPQEAPHVQYERLGADVTLPCGTASWDAAVTWRVNGTDLAPDLLNGSQLILRSLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMVCEKDPALKNRCHIRYMHLFSTIKYKVSISVSNALGHNTTAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHATPWTEEPRHLTTEAQAPETTTSTTSSLAPPPTTKICDPGELGSGGGPSILFLTSVPVTLVLAAAAATANNLLI
uniprot
proteins
function
FUNCTION: Functions either as a membrane-anchored non-signaling receptor via a GPI anchor or, after proteolytic release, as a soluble ligand-binding chaperone, and mediates signaling of CNTF-related cytokines, including ciliary neurotrophic factor (CNTF), cardiotrophin-like cytokine factor 1 (CLCF1), and the heterodimeric cytokine formed by CLCF1 and the cytokine receptor-like factor 1 (CRLF1). Involved namely in cell survival of motor neurons and regulation of oligodendrocyte progenitor proliferation. Functions within the ciliary neurotrophic factor receptor (CNTFR) complex as a membrane-anchored non-signaling receptor subunit associated with two other signaling receptor subunits IL6ST/gp130 and LIFR. Alternatively functions as a soluble ligand-binding chaperone that binds ligand in the extracellular space, forming a cytokine complex which is delivered to the IL6ST/gp130 and LIFR signaling receptor subunits. Mechanistically, ligand binding to the CNTFR induces dimerization of the IL6ST/gp130 and LIFR (or IL27RA/WSX1 in the case of MT-RNR2/humanin), which activate JAK tyrosine kinases (JAK1 or JAK2 and to lesser extent TYK2) bound to their intracellular domains. These kinases subsequently phosphorylate IL6ST/gp130 and LIFR (or IL27RA/WSX1). The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducer and activators of transcription (STAT3 and to lesser extent STAT1). {ECO:0000250|UniProtKB:P26992}.
uniprot
proteins
mass_dalton
40801
uniprot
proteins
post_translational_modification
PTM: GPI processing by GDPD2 releases 2 soluble forms, a 100 kDa form and a 90 kDa form. In vitro, GPI processing is also mediated by a phosphatidylinositol (PI) phospholipase C (PI-PLC) releasing a soluble form of 90 kDa. The 100 kDa form is released by extracellular vesicles. {ECO:0000250|UniProtKB:P26992}.
uniprot
proteins
protein_family
Type 3 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
372
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P26992}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P26992}. Secreted {ECO:0000250|UniProtKB:P26992}. Note=Localized at cell membrane when associated with SORL1. Released from plasma membrane and extracellular vesicles (EV) by GDPD2. {ECO:0000250|UniProtKB:P26992}.
uniprot
proteins