Calhm6
entrez
215900
canonical
uniprot
Q8C9E8
canonical
ensembl
ENSMUSG00000046031
resolver
ensp
ENSMUSP00000051575
resolver
enst
ENSMUST00000062784
resolver
genesymbol
Calhm6
resolver
genesymbol_syn
Fam26f
resolver
uniprot_entry
CAHM6_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by Gd(3+). Partially inhibited by divalent ions Ca(2+) and Ba(2+). {ECO:0000269|PubMed:36861806}.
uniprot
proteins
amino_acid_sequence
MEKFKAVLDLQRKHRNALGYSLVTLLTAGGEKIFSSVVFQCPCTATWNLPYGLVFLLVPALALFLLGYALSARTWRLLTGCCSRSARFSSGLRSAFVCAQLSMTAAFAPLTWVAVALLEGSFYQCAVSGSARLAPYLCKGRDPNCNATLPQAPCNKQKVEMQEILSQLKAQSQVFGWILIAAVIILLLLVKSVTRCFSPVSYLQLKFWEIYWEKEKQILQNQAAENATQLAEENVRCFFECSKPKECNTPSSKDWQEISALYTFNPKNQFYSMLHKYVSREEMSGSVRSVEGDAVIPALGFVDDMSMTNTHEL
uniprot
proteins
function
FUNCTION: Pore-forming subunit of an ATP-permeable channel (PubMed:21059856, PubMed:36861806). In response to pathogen-derived and proinflammatory stimuli, relocates from intracellular compartments to NK-dendritic cell and NK-macrophage immune synapses where it mediates ATP efflux and NK cell activation involved in antimicrobial and antitumor responses (PubMed:21059856, PubMed:36861806). May assemble to form gap junction channel-like structures with gating and ion conductance likely regulated by membrane lipids and voltage rather than by extracellular calcium levels (By similarity). {ECO:0000250|UniProtKB:Q5R3K3, ECO:0000269|PubMed:21059856, ECO:0000269|PubMed:36861806}.
uniprot
proteins
mass_dalton
34956
uniprot
proteins
mutagenesis
MUTAGEN 119; /note="E->R: Loss-of-function. Abolishes ATP release. Does not affect localization at the plasma membrane."; /evidence="ECO:0000269|PubMed:36861806
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:21059856}.
uniprot
proteins
protein_family
CALHM family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21059856
uniprot
proteins
pubmed
36861806
uniprot
proteins
sequence_length
313
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21059856, ECO:0000269|PubMed:36861806}; Multi-pass membrane protein {ECO:0000255}. Note=Recruited at immune synapses in response to pathogen-derived and proinflammatory stimuli. {ECO:0000269|PubMed:36861806}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..37; /note="Helical; Name=S1"; /evidence="ECO:0000250|UniProtKB:Q5R3K3"; TRANSMEM 47..68; /note="Helical; Name=S2"; /evidence="ECO:0000250|UniProtKB:Q5R3K3"; TRANSMEM 102..126; /note="Helical; Name=S3"; /evidence="ECO:0000250|UniProtKB:Q5R3K3"; TRANSMEM 168..190; /note="Helical; Name=S4"; /evidence="ECO:0000250|UniProtKB:Q5R3K3
uniprot
proteins