Kpnb1
entrez
16211
canonical
uniprot
P70168
canonical
ensembl
ENSMUSG00000001440
resolver
ensp
ENSMUSP00000001479
resolver
enst
ENSMUST00000001479
resolver
genesymbol
Kpnb1
resolver
genesymbol_syn
Impnb
resolver
uniprot
Q3UHW8
resolver
uniprot
Q62117
resolver
uniprot
Q6GTI5
resolver
uniprot_entry
IMB1_MOUSE
resolver
uniprot_entry
Q3UHW8_MOUSE
resolver
uniprot_sec
Q62117
resolver
uniprot_sec
Q6GTI5
resolver
amino_acid_sequence
MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQIKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAEIPVSQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLSTCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGSILEGPEPNQLKPLVIQAMPTLIELMKDPSVVVRDTTAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDALQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQSNILPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDIALAIGGEFKKYLEVVLNTLQQASQAQVDKSDFDMVDYLNELRESCLEAYTGIVQGLKGDQENVHPDVMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEARPMIHELLTEGRRSKTNKAKTLATWATKELRKLKNQA
uniprot
proteins
function
FUNCTION: Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor (PubMed:11493596). Acting autonomously, serves itself as NLS receptor (By similarity). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (By similarity). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin (By similarity). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (By similarity). In association with IPO7, mediates the nuclear import of H1 histone (By similarity). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones (PubMed:11493596). Imports MRTFA, SNAI1 and PRKCI into the nucleus (By similarity). {ECO:0000250|UniProtKB:Q14974, ECO:0000269|PubMed:11493596}.
uniprot
proteins
mass_dalton
97184
uniprot
proteins
post_translational_modification
PTM: Mono-ADP-ribosylated by PARP16. {ECO:0000250|UniProtKB:Q14974}.
uniprot
proteins
protein_family
Importin beta family
uniprot
proteins
protein_family
Importin beta-1 subfamily
uniprot
proteins
pubmed
10964573
uniprot
proteins
pubmed
11493596
uniprot
proteins
pubmed
11535586
uniprot
proteins
pubmed
14645851
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20699224
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25946333
uniprot
proteins
pubmed
7635189
uniprot
proteins
pubmed
8812441
uniprot
proteins
sequence_length
876
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q14974}. Nucleus envelope {ECO:0000250|UniProtKB:Q14974}.
uniprot
proteins