Rassf1
entrez
56289
canonical
uniprot
Q99MK9
canonical
ensembl
ENSMUSG00000010067
resolver
ensp
ENSMUSP00000010211
resolver
ensp
ENSMUSP00000091301
resolver
genesymbol
Rassf1
resolver
uniprot
A9YZW8
resolver
uniprot
Q3UIV8
resolver
uniprot
Q9WUF5
resolver
uniprot_entry
A9YZW8_MOUSE
resolver
uniprot_entry
Q3UIV8_MOUSE
resolver
uniprot_entry
RASF1_MOUSE
resolver
uniprot_sec
Q9WUF5
resolver
amino_acid_sequence
MSAEPELIELRELAPSGRIGPGRTRLERANALRIAPGTTRNPSQQHVPGRGHRFQPAGPTTHTWCDLCGDFIWGVVRKGLQCAHCKFTCHYRCRALVCLDCCGPRDLGWDSALERDTNVDEAVERETPDLSQAETEQKIKDYNGQINSNLFMSLNKDGSYTGFIKVQLKLVRPVSVPSSKKPPSLQDARRGTGRSTAVKRRTSFYLPKDAIKHLHVLSRTRAREVIEALLRKFMVVDDPRKFALFERTERHGQVYLRKLSDDEQPLKLRLLAGPSEKALSFVLKENDSGEVNWDAFSMPELHNFLRILQREEEEHLRQILQKYSRCRQKIQEALHACPLG
uniprot
proteins
function
FUNCTION: Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
38789
uniprot
proteins
pubmed
11333291
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17335777
uniprot
proteins
pubmed
23294242
uniprot
proteins
sequence_length
340
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform A]: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250}. Note=Localizes to cytoplasmic microtubules during interphase, to bipolar centrosomes associated with microtubules during prophase, to spindle fibers and spindle poles at metaphase and anaphase, to the midzone during early telophase, and to the midbody in late telophase in cells. Colocalizes with MDM2 in the nucleus (By similarity). {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform C]: Nucleus {ECO:0000250}. Note=Predominantly nuclear. {ECO:0000250}.
uniprot
proteins