Sh3kbp1
entrez
58194
canonical
uniprot
Q8R550
canonical
ensembl
ENSMUSG00000040990
resolver
ensp
ENSMUSP00000072840
resolver
ensp
ENSMUSP00000079257
resolver
ensp
ENSMUSP00000108070
resolver
ensp
ENSMUSP00000108075
resolver
ensp
ENSMUSP00000117618
resolver
ensp
ENSMUSP00000226438
resolver
ensp
ENSMUSP00000226441
resolver
genesymbol
Sh3kbp1
resolver
genesymbol_syn
Ruk
resolver
genesymbol_syn
Seta
resolver
uniprot
B1AZ86
resolver
uniprot
B1AZ87
resolver
uniprot
Q3TA88
resolver
uniprot
Q3TT90
resolver
uniprot
Q8CAL8
resolver
uniprot
Q8CEF6
resolver
uniprot
Q8R545
resolver
uniprot
Q8R546
resolver
uniprot
Q8R547
resolver
uniprot
Q8R548
resolver
uniprot
Q8R549
resolver
uniprot
Q8R551
resolver
uniprot
Q9CTQ9
resolver
uniprot
Q9DC14
resolver
uniprot
Q9JKC3
resolver
uniprot_entry
Q3TA88_MOUSE
resolver
uniprot_entry
Q3TT90_MOUSE
resolver
uniprot_entry
SH3K1_MOUSE
resolver
uniprot_sec
B1AZ86
resolver
uniprot_sec
B1AZ87
resolver
uniprot_sec
Q8CAL8
resolver
uniprot_sec
Q8CEF6
resolver
uniprot_sec
Q8R545
resolver
uniprot_sec
Q8R546
resolver
uniprot_sec
Q8R547
resolver
uniprot_sec
Q8R548
resolver
uniprot_sec
Q8R549
resolver
uniprot_sec
Q8R551
resolver
uniprot_sec
Q9CTQ9
resolver
uniprot_sec
Q9DC14
resolver
uniprot_sec
Q9JKC3
resolver
amino_acid_sequence
MVEAIVEFDYQAQHDDELTISVGEVITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKDMKKDLLSNKAPEKPMHDVSSGNALLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSRPEGFLPASLLPFPAHGAKGKTTFEGTILYRAAPGKTEGHRRYYSLRETTGSESDGGDSSSTKSEGANGTMATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPPATSTPDPSKTEMDSRTKTKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPSDFDKEGNRPKKPPPPSAPVVKQGAGTTERKHEIKKIPPERPETLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLNRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSALSGILDKDLSDRSNDIDLEGFDSVISSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGIDVSKKTSKTVTISQVSDNKTSLPPKPGTMAAASSGPASLSSVASSPMSSSLGTAGQRASSPSLFSTEGKPKMEPAVSSQAAIEELKMQVRELRTIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK
uniprot
proteins
function
FUNCTION: Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration (By similarity). Has an essential role in the stimulation of B cell activation (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q96B97}.
uniprot
proteins
mass_dalton
78170
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated by CBL and CBLB after EGF stimulation; probably on its C-terminus. {ECO:0000250}.
uniprot
proteins
pubmed
10965144
uniprot
proteins
pubmed
11152963
uniprot
proteins
pubmed
12242006
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18602463
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21830225
uniprot
proteins
pubmed
29589748
uniprot
proteins
sequence_length
709
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96B97}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Synapse, synaptosome {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Note=Localized in endocytic vesicles containing clustered receptors. Colocalizes with ASAP1 in vesicular structures. Colocalized with actin microfilaments and focal adhesions (By similarity). Colocalized with MAGI2 in synaptosomes (By similarity). Translocation to EGFR containing vesicles upon EGF stimulation is inhibited in the presence of SH3KBP1 (PubMed:21830225). Colocalizes with ZFP36 in the cytoplasm (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q96B97, ECO:0000269|PubMed:21830225}.
uniprot
proteins