Drg1
entrez
13494
canonical
uniprot
P32233
canonical
ensembl
ENSMUSG00000020457
resolver
ensp
ENSMUSP00000020741
resolver
ensp
ENSMUSP00000164314
resolver
enst
ENSMUST00000020741
resolver
genesymbol
Drg1
resolver
genesymbol_syn
Drg
resolver
genesymbol_syn
Nedd-3
resolver
genesymbol_syn
Nedd3
resolver
uniprot
Q5NBZ3
resolver
uniprot_entry
DRG1_MOUSE
resolver
uniprot_entry
Q5NBZ3_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: The GTPase activity is enhanced by potassium ions as well as by DFRP1 binding. {ECO:0000250|UniProtKB:Q9Y295}.
uniprot
proteins
amino_acid_sequence
MSGTLAKIAEIEAEMARTQKNKATAHHLGLLKARLAKLRRELITPKGGGGGGPGEGFDVAKTGDARIGFVGFPSVGKSTLLSNLAGVYSEVAAYEFTTLTTVPGVIRYKGAKIQLLDLPGIIEGAKDGKGRGRQVIAVARTCNLILIVLDVLKPLGHKKIIENELEGFGIRLNSKPPNIGFKKKDKGGINLTATCPQSELDAETVKSILAEYKIHNADVTLRSDATADDLIDVVEGNRVYIPCIYVLNKIDQISIEELDIIYKVPHCVPISAHHRWNFDDLLEKIWDYLKLVRIYTKPKGQLPDYTSPVVLPYSRTTVEDFCMKIHKNLIKEFKYALVWGLSVKHNPQKVGKDHTLEDEDVIQIVKK
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of GTP to GDP through hydrolysis of the gamma-phosphate bond in GTP. Appears to have an intrinsic GTPase activity that is stimulated by ZC3H15/DFRP1 binding likely by increasing the affinity for the potassium ions. When hydroxylated at C-3 of 'Lys-22' by JMJD7, may bind to RNA and play a role in translation. Binds to microtubules and promotes microtubule polymerization and bundling that are required for mitotic spindle assembly during prophase to anaphase transition. GTPase activity is not necessary for these microtubule-related functions. {ECO:0000250|UniProtKB:Q9Y295}.
uniprot
proteins
mass_dalton
40512
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated; this modification induces proteolytic degradation and is impaired by interaction with ZC3H15. {ECO:0000305|PubMed:15676025}.; PTM: Sumoylated by UBE2I in response to MEKK1-mediated stimuli. {ECO:0000250|UniProtKB:Q9Y295}.; PTM: Hydroxylated (with S stereochemistry) at C-3 of Lys-22 by JMJD7. {ECO:0000250|UniProtKB:Q9Y295}.; PTM: Phosphorylated at Thr-100 by STK16. {ECO:0000250|UniProtKB:Q9Y295}.
uniprot
proteins
protein_family
OBG GTPase family
uniprot
proteins
protein_family
TRAFAC class OBG-HflX-like GTPase superfamily
uniprot
proteins
pubmed
1280421
uniprot
proteins
pubmed
1449490
uniprot
proteins
pubmed
15676025
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
367
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y295}. Cytoplasm {ECO:0000269|PubMed:1280421}. Note=The DRG1-DFRP2/ZC3H15 complex associates with polysomes. {ECO:0000250|UniProtKB:Q9Y295}.
uniprot
proteins