Gucy2f
entrez
116556
canonical
uniprot
P51842
canonical
ensembl
ENSRNOG00000019086
resolver
ensembl
ENSRNOG00055024843
resolver
ensembl
ENSRNOG00060018767
resolver
ensp
ENSRNOP00000049500
resolver
ensp
ENSRNOP00055034969
resolver
ensp
ENSRNOP00060026356
resolver
enst
ENSRNOT00000046804
resolver
enst
ENSRNOT00055042821
resolver
enst
ENSRNOT00060032345
resolver
genesymbol
Gucy2f
resolver
genesymbol_syn
Guc2f
resolver
uniprot_entry
GUC2F_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by GUCA1B when free calcium ions concentration is low, and inhibited by GUCA1B when free calcium ions concentration is high (By similarity). Inhibited by RD3 (By similarity). {ECO:0000250|UniProtKB:O02740, ECO:0000250|UniProtKB:P51841}.
uniprot
proteins
amino_acid_sequence
MFLGPWPFSRLLSWFAISSRLSGQHGLTSSKFLRYLCLLALLPLIWWGQALPYKIGVIGPWTCDPFFSKALPEVAAALAIERISRDMSFDRSYSFEYVILNEDCQTSKALTSFISHQQMASGFVGPANPGYCEAASLLGNSWDKGIFSWACVNHELDNKHSYPTFSRTLPSPIRVLVTVMKYFQWAHAGVISSDEDIWVHTANQVSSALRSHGLPVGVVLTSGQDSRSIQKALQQIRQADRIRIIIMCMHSALIGGETQTHFLELAHDLKMTDGTYVFVPYDVLLYSLPYKHSPYQVLRNNQKLREAYDAVLTITVESHEKTFYEAFTEAAAGGEIPEKLDSHQVSPLFGTIYNSIYFIAQAMSNALKENGQASAASLTRHSRNMQFYGFNQLIRTDSNGNGISEYVILDTNGKEWELRGTYTVDMETELLRFRGTPIHFPGGRPTSADAKCWFAQGKICQGGIDPALAMMVCFALLLALLSINGFAYFIRRRINKIQLIKGPNRILLTLEDVTFINPHFGSKRGSRASVSFQIISEVQSGRSPRLSFSSGSLTPATYENSNIAIYQGDWVWLKKFPPGDFGDIKSIKSSASDVFEMMKDLRHENVNPLLGFFYDSGMFAIVSEFCSRRSLEDILTQDDVKLDWMFKSSLLLDLIKGMKYLHHREFIHGRLKSRNCVVDGRFVLKVTDYGFNNILEMLRLSEEEPSEEELLWTAPELLRAPGGIRLGSFAGDVYSFAIIMQEVMVRGAPFCMMDLSAKEVIDRLKMPPPVYRPVVSPEFAPPECLQLMKQCWAEAAEQRPTFDEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPPSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILRTLSEGYEVELRGRTELKGKGTEETFWLVGKKGFTKPLPVPPPVGKDGQVGHGLQPAEIAAFQRRKAERQLVRNKP
uniprot
proteins
ec_number
4.6.1.2
uniprot
proteins
function
FUNCTION: Responsible for the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment (PubMed:7831337). May also participate in the trafficking of membrane-associated proteins to the photoreceptor outer segment membrane (By similarity). {ECO:0000250|UniProtKB:Q5SDA5, ECO:0000269|PubMed:7831337}.
uniprot
proteins
mass_dalton
124411
uniprot
proteins
post_translational_modification
PTM: There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds.
uniprot
proteins
protein_family
Adenylyl cyclase class-4/guanylyl cyclase family
uniprot
proteins
pubmed
7831337
uniprot
proteins
pubmed
9153227
uniprot
proteins
sequence_length
1108
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:7831337}; Single-pass type I membrane protein. Photoreceptor outer segment membrane {ECO:0000250|UniProtKB:O02740}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 466..490; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins