KBTBD4
entrez
55709
canonical
uniprot
Q9NVX7
canonical
ensembl
ENSG00000123444
resolver
ensembl
ENSG00000284900
resolver
ensp
ENSP00000378703
resolver
ensp
ENSP00000415106
resolver
ensp
ENSP00000433340
resolver
ensp
ENSP00000436713
resolver
ensp
ENSP00000791226
resolver
genesymbol
KBTBD4
resolver
genesymbol_syn
BKLHD4
resolver
hgnc
HGNC:23761
resolver
uniprot
A0A075B6T4
resolver
uniprot
B3KRH9
resolver
uniprot
D3DQS1
resolver
uniprot
D3DQS2
resolver
uniprot
Q6IA85
resolver
uniprot
Q9BUC3
resolver
uniprot
Q9NV76
resolver
uniprot_entry
KBTB4_HUMAN
resolver
uniprot_sec
A0A075B6T4
resolver
uniprot_sec
B3KRH9
resolver
uniprot_sec
D3DQS1
resolver
uniprot_sec
D3DQS2
resolver
uniprot_sec
Q6IA85
resolver
uniprot_sec
Q9BUC3
resolver
uniprot_sec
Q9NV76
resolver
amino_acid_sequence
MKGGNADSWQREKLASMESPEEPGASMDENYFVNYTFKDRSHSGRVAQGIMKLCLEEELFADVTISVEGREFQLHRLVLSAQSCFFRSMFTSNLKEAHNRVIVLQDVSESVFQLLVDYIYHGTVKLRAEELQEIYEVSDMYQLTSLFEECSRFLARTVQVGNCLQVMWLADRHSDPELYTAAKHCAKTHLAQLQNTEEFLHLPHRLLTDIISDGVPCSQNPTEAIEAWINFNKEEREAFAESLRTSLKEIGENVHIYLIGKESSRTHSLAVSLHCAEDDSISVSGQNSLCHQITAACKHGGDLYVVGGSIPRRMWKCNNATVDWEWCAPLPRDRLQHTLVSVPGKDAIYSLGGKTLQDTLSNAVIYYRVGDNVWTETTQLEVAVSGAAGANLNGIIYLLGGEENDLDFFTKPSRLIQCFDTETDKCHVKPYVLPFAGRMHAAVHKDLVFIVAEGDSLVCYNPLLDSFTRLCLPEAWSSAPSLWKIASCNGSIYVFRDRYKKGDANTYKLDPATSAVTVTRGIKVLLTNLQFVLA
uniprot
proteins
function
FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex which targets CoREST corepressor complex components RCOR1, KDM1A/LSD1 and HDAC2 for proteasomal degradation (PubMed:33417871). RCOR1 is likely to be the primary target while degradation of KDM1A and HDAC2 is likely due to their association with RCOR1 (PubMed:33417871). Also targets RCOR3, MIER2 and MIER3 for proteasomal degradation as well as associated proteins ZNF217 and RREB1 (PubMed:36997086). Degradation is dependent on the presence of an ELM2 domain in the target proteins (PubMed:36997086). {ECO:0000269|PubMed:33417871, ECO:0000269|PubMed:36997086}.
uniprot
proteins
mass_dalton
59904
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
33417871
uniprot
proteins
pubmed
36997086
uniprot
proteins
sequence_length
534
uniprot
proteins