IL36RN
entrez
26525
canonical
uniprot
Q9UBH0
canonical
ensembl
ENSG00000136695
resolver
ensp
ENSP00000259212
resolver
ensp
ENSP00000376896
resolver
ensp
ENSP00000409262
resolver
enst
ENST00000346807
resolver
enst
ENST00000393200
resolver
enst
ENST00000437409
resolver
genesymbol
IL36RN
resolver
genesymbol_syn
FIL1D
resolver
genesymbol_syn
IL1F5
resolver
genesymbol_syn
IL1HY1
resolver
genesymbol_syn
IL1L1
resolver
genesymbol_syn
IL1RP3
resolver
hgnc
HGNC:15561
resolver
uniprot
A8K2I4
resolver
uniprot
Q56AT9
resolver
uniprot
Q7RTZ6
resolver
uniprot_entry
I36RA_HUMAN
resolver
uniprot_sec
A8K2I4
resolver
uniprot_sec
Q56AT9
resolver
uniprot_sec
Q7RTZ6
resolver
amino_acid_sequence
MVLSGALCFRMKDSALKVLYLHNNQLLAGGLHAGKVIKGEEISVVPNRWLDASLSPVILGVQGGSQCLSCGVGQEPTLTLEPVNIMELYLGAKESKSFTFYRRDMGLTSSFESAAYPGWFLCTVPEADQPVRLTQLPENGGWNAPITDFYFQQCD
uniprot
proteins
disease_involvement
DISEASE: Psoriasis 14, pustular (PSORS14) [MIM:614204]: A life-threatening disease defined by repeated flares of sudden onset consisting of diffuse erythematous skin eruption characterized by rapid coverage with pustules, high-grade fever, asthenia, marked leukocytosis, and elevated serum levels of C-reactive protein. {ECO:0000269|PubMed:21839423, ECO:0000269|PubMed:21848462, ECO:0000269|PubMed:22903787}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. {ECO:0000269|PubMed:11466363, ECO:0000269|PubMed:21965679, ECO:0000269|PubMed:23147407}.
uniprot
proteins
mass_dalton
16962
uniprot
proteins
protein_family
IL-1 family
uniprot
proteins
pubmed
10512743
uniprot
proteins
pubmed
10625660
uniprot
proteins
pubmed
10860666
uniprot
proteins
pubmed
11093146
uniprot
proteins
pubmed
11466363
uniprot
proteins
pubmed
11991722
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
21839423
uniprot
proteins
pubmed
21848462
uniprot
proteins
pubmed
21965679
uniprot
proteins
pubmed
22903787
uniprot
proteins
pubmed
23147407
uniprot
proteins
pubmed
32272059
uniprot
proteins
sequence_length
155
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:32272059}. Secreted {ECO:0000269|PubMed:32272059}. Note=The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. {ECO:0000269|PubMed:32272059}.
uniprot
proteins