Socs2
entrez
84607
canonical
uniprot
O88582
canonical
ensembl
ENSRNOG00000008965
resolver
ensembl
ENSRNOG00055006134
resolver
ensp
ENSRNOP00000089730
resolver
ensp
ENSRNOP00000100589
resolver
ensp
ENSRNOP00055007690
resolver
enst
ENSRNOT00000103867
resolver
enst
ENSRNOT00000167189
resolver
enst
ENSRNOT00055009943
resolver
genesymbol
Socs2
resolver
genesymbol_syn
Cish2
resolver
uniprot
A0A8I6AD64
resolver
uniprot
A0ABK0LGH1
resolver
uniprot_entry
A0A8I6AD64_RAT
resolver
uniprot_entry
A0ABK0LGH1_RAT
resolver
uniprot_entry
SOCS2_RAT
resolver
amino_acid_sequence
MTLRCLEPSGNGADRTRSQWGTAGSPEDQSPEAARLAKALRELSQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTSAPTLQHFCRLSINKCTGTIRGLPLPTRLKDYLEEYKFQV
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as EPOR and GHR. Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination. The ECS(SOCS2) complex acts as a key regulator of growth hormone receptor (GHR) levels by mediating ubiquitination and degradation of GHR, following GHR phosphorylation by JAK2. The ECS(SOCS2) also catalyzes ubiquitination and degradation of JAK2-phosphorylated EPOR. {ECO:0000250|UniProtKB:O14508}.
uniprot
proteins
mass_dalton
22380
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:O14508}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; mediated by AREL1 and leading to its subsequent proteasomal degradation. Ubiquitination is dependent on its phosphorylation at Ser-52, by PKC (By similarity). Ubiquitination is stimulated by LPS (By similarity). {ECO:0000250|UniProtKB:O14508, ECO:0000250|UniProtKB:O35717}.; PTM: Phosphorylation at Ser-52 by PKC facilitates its ubiquitination and proteasomal degradation. {ECO:0000250|UniProtKB:O14508}.
uniprot
proteins
pubmed
10579313
uniprot
proteins
sequence_length
198
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O14508}.
uniprot
proteins