Kcnc2
entrez
246153
canonical
uniprot
P22462
canonical
ensembl
ENSRNOG00000004077
resolver
ensembl
ENSRNOG00055012317
resolver
ensembl
ENSRNOG00060003730
resolver
ensembl
ENSRNOG00065013851
resolver
ensp
ENSRNOP00000005690
resolver
genesymbol
Kcnc2
resolver
uniprot
P22461
resolver
uniprot
P22463
resolver
uniprot
Q63735
resolver
uniprot_entry
KCNC2_RAT
resolver
uniprot_sec
P22461
resolver
uniprot_sec
P22463
resolver
uniprot_sec
Q63735
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by Stichodactyla helianthus peptide ShK (By similarity). Inhibited by millimolar levels of tetraethylammonium (TEA). Contrary to other channels, inhibited only by millimolar levels of 4-aminopyridine (4-AP) (PubMed:10414303, PubMed:10482766, PubMed:1879548, PubMed:2367536, PubMed:7643197). {ECO:0000250|UniProtKB:Q96PR1, ECO:0000269|PubMed:10482766, ECO:0000269|PubMed:1879548, ECO:0000269|PubMed:2367536, ECO:0000269|PubMed:7643197, ECO:0000305|PubMed:10414303}.
uniprot
proteins
amino_acid_sequence
MGKIENNERVILNVGGTRHETYRSTLKTLPGTRLALLASSEPQGDCLTAAGDKLQPLPPPLSPPPRPPPLSPVPSGCFEGGAGNCSSHGGNGSDHPGGGREFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPGDDEDLGGKRLGIEDAAGLGGPDGKSGRWRKLQPRMWALFEDPYSSRAARFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSAVLQYEIETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPLASSPTFCKTELNMACNSTQSDTCLGKENRLLEHNRSVLSGDDSTGSEPPLSPPERLPIRRSSTRDKNRRGETCFLLTTGDYTCASDGGIRKGYEKSRSLNNIAGLAGNALRLSPVTSPYNSPCPLRRSRSPIPSIL
uniprot
proteins
function
FUNCTION: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Contributes to the regulation of the fast action potential repolarization and in sustained high-frequency firing in neurons of the central nervous system (PubMed:10414968, PubMed:10482766, PubMed:11506885, PubMed:22831914). Homotetramer channels mediate delayed-rectifier voltage-dependent potassium currents that activate rapidly at high-threshold voltages and inactivate slowly (PubMed:10414303, PubMed:10482766, PubMed:11281123, PubMed:14679187, PubMed:1879548, PubMed:2367536, PubMed:7643197, PubMed:8120636). Forms tetrameric channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane (PubMed:1879548, PubMed:2367536, PubMed:7643197, PubMed:8120636). Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC1, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:10482766, PubMed:14679187). Channel properties may be modulated either by the association with ancillary subunits, such as KCNE1, KCNE2 and KCNE3 or indirectly by nitric oxide (NO) through a cGMP- and PKG-mediated signaling cascade, slowing channel activation and deactivation of delayed rectifier potassium channels (PubMed:11281123, PubMed:14679187). Contributes to fire sustained trains of very brief action potentials at high frequency in retinal ganglion cells, thalamocortical and suprachiasmatic nucleus (SCN) neurons and in hippocampal and neocortical interneurons (PubMed:10414968, PubMed:10482766, PubMed:11506885, PubMed:22831914). Sustained maximal action potential firing frequency in inhibitory hippocampal interneurons is negatively modulated by histamine H2 receptor activation in a cAMP- and protein kinase (PKA) phosphorylation-dependent manner. Plays a role in maintaining the fidelity of synaptic transmission in neocortical GABAergic interneurons by generating action potential (AP) repolarization at nerve terminals, thus reducing spike-evoked calcium influx and GABA neurotransmitter release. Required for long-range synchronization of gamma oscillations over distance in the neocortex. Contributes to the modulation of the circadian rhythm of spontaneous action potential firing in suprachiasmatic nucleus (SCN) neurons in a light-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q14B80, ECO:0000269|PubMed:10414968, ECO:0000269|PubMed:10482766, ECO:0000269|PubMed:11281123, ECO:0000269|PubMed:11506885, ECO:0000269|PubMed:14679187, ECO:0000269|PubMed:1879548, ECO:0000269|PubMed:22831914, ECO:0000269|PubMed:2367536, ECO:0000269|PubMed:7643197, ECO:0000269|PubMed:8120636, ECO:0000305|PubMed:10414303, ECO:0000305|PubMed:11506885}.
uniprot
proteins
mass_dalton
70191
uniprot
proteins
mutagenesis
MUTAGEN 563; /note="S->A: Does not abolish channel activity inhibition in presence of nitric oxide (NO); when associated with A-564. Absence of channel activity inhibition in presence of cAMP; when associated with A-564."; /evidence="ECO:0000269|PubMed:11281123, ECO:0000269|PubMed:7643197"; MUTAGEN 564; /note="S->A: Does not abolish channel activity inhibition in presence of nitric oxide (NO); when associated with A-564. Absence of channel activity inhibition in presence of cAMP; when associated with A-563."; /evidence="ECO:0000269|PubMed:11281123, ECO:0000269|PubMed:7643197
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKA in cortical synaptosomes (PubMed:7643197). cAMP-dependent phosphorylation inhibits channel activity (PubMed:7643197). Histamine H2 receptor- and PKA-induced phosphorylation extends action potential spike duration, reduces action potential spike amplitude, sustains maximum firing frequency in hippocampal interneurons; also reduces the incidence of high-frequency oscillations in hippocampal CA3 pyramidal cell layers (By similarity). {ECO:0000250|UniProtKB:P63142, ECO:0000269|PubMed:7643197}.
uniprot
proteins
protein_family
C (Shaw) (TC 1.A.1.2) subfamily
uniprot
proteins
protein_family
Kv3.2/KCNC2 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
10414303
uniprot
proteins
pubmed
10414968
uniprot
proteins
pubmed
10482766
uniprot
proteins
pubmed
11281123
uniprot
proteins
pubmed
11506885
uniprot
proteins
pubmed
1374908
uniprot
proteins
pubmed
1378392
uniprot
proteins
pubmed
14679187
uniprot
proteins
pubmed
16413129
uniprot
proteins
pubmed
18708127
uniprot
proteins
pubmed
18775767
uniprot
proteins
pubmed
1879548
uniprot
proteins
pubmed
2023956
uniprot
proteins
pubmed
22831914
uniprot
proteins
pubmed
2367536
uniprot
proteins
pubmed
7643197
uniprot
proteins
pubmed
8120636
uniprot
proteins
pubmed
9307441
uniprot
proteins
sequence_length
638
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10414968, ECO:0000269|PubMed:10482766, ECO:0000269|PubMed:14679187, ECO:0000269|PubMed:22831914, ECO:0000269|PubMed:7643197}; Multi-pass membrane protein {ECO:0000255}. Membrane {ECO:0000269|PubMed:11281123}; Multi-pass membrane protein {ECO:0000255}. Perikaryon {ECO:0000269|PubMed:10482766}. Cell projection, axon {ECO:0000269|PubMed:7643197}. Synapse {ECO:0000269|PubMed:7643197}. Synapse, synaptosome {ECO:0000269|PubMed:7643197}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q14B80}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q14B80}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q14B80}. Note=Localizes on the surface of cell somata, proximal dendrites and axonal membranes. Also detected throughout the neuropil. Localized in starburst cell somata and proximal dendrite processes. Colocalized with GABA in presynaptic terminals. Clustered in patches in somatic and proximal dendritic membrane as well as in axons and presnypatic terminals of GABAergic interneurons; some of these patches are found near postsynaptic sites (By similarity). Colocalizes with parvalbumin in globus pallidus neurons (PubMed:10482766). Localizes in thalamocortical axons and synapses (PubMed:7643197). {ECO:0000250|UniProtKB:Q14B80, ECO:0000269|PubMed:10482766, ECO:0000269|PubMed:7643197}.; SUBCELLULAR LOCATION: [Isoform 1]: Apical cell membrane {ECO:0000269|PubMed:9307441}.; SUBCELLULAR LOCATION: [Isoform 2]: Apical cell membrane {ECO:0000269|PubMed:9307441}.; SUBCELLULAR LOCATION: [Isoform 3]: Basolateral cell membrane {ECO:0000269|PubMed:9307441}.
uniprot
proteins
transmembrane_region
TRANSMEM 230..248; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 284..303; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 315..337; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 346..368; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 382..401; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 451..473; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins