MTARC2
entrez
54996
canonical
uniprot
Q969Z3
canonical
ensembl
ENSG00000117791
resolver
ensp
ENSP00000352266
resolver
ensp
ENSP00000355880
resolver
ensp
ENSP00000536848
resolver
genesymbol
MTARC2
resolver
genesymbol_syn
MARC2
resolver
genesymbol_syn
MOSC2
resolver
hgnc
HGNC:26064
resolver
uniprot
B2D0R5
resolver
uniprot
D3DTB3
resolver
uniprot
Q0JSK7
resolver
uniprot
Q5VT67
resolver
uniprot
Q5VXC7
resolver
uniprot
Q7L317
resolver
uniprot
Q9H066
resolver
uniprot
Q9NWU0
resolver
uniprot_entry
MARC2_HUMAN
resolver
uniprot_sec
B2D0R5
resolver
uniprot_sec
D3DTB3
resolver
uniprot_sec
Q0JSK7
resolver
uniprot_sec
Q5VT67
resolver
uniprot_sec
Q5VXC7
resolver
uniprot_sec
Q7L317
resolver
uniprot_sec
Q9H066
resolver
uniprot_sec
Q9NWU0
resolver
amino_acid_sequence
MGASSSSALARLGLPARPWPRWLGVAALGLAAVALGTVAWRRAWPRRRRRLQQVGTVAKLWIYPVKSCKGVPVSEAECTAMGLRSGNLRDRFWLVIKEDGHMVTARQEPRLVLISIIYENNCLIFRAPDMDQLVLPSKQPSSNKLHNCRIFGLDIKGRDCGNEAAKWFTNFLKTEAYRLVQFETNMKGRTSRKLLPTLDQNFQVAYPDYCPLLIMTDASLVDLNTRMEKKMKMENFRPNIVVTGCDAFEEDTWDELLIGSVEVKKVMACPRCILTTVDPDTGVIDRKQPLDTLKSYRLCDPSERELYKLSPLFGIYYSVEKIGSLRVGDPVYRMV
uniprot
proteins
ec_number
1.7.-.-
uniprot
proteins
function
FUNCTION: Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles (PubMed:21029045, PubMed:24423752). As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability (PubMed:21029045, PubMed:24423752). May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis (PubMed:21029045). Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction (PubMed:21029045). {ECO:0000269|PubMed:21029045, ECO:0000269|PubMed:24423752}.
uniprot
proteins
mass_dalton
38023
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. {ECO:0000269|PubMed:25621951}.
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21029045
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24423752
uniprot
proteins
pubmed
25621951
uniprot
proteins
sequence_length
335
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane; Peripheral membrane protein. Peroxisome {ECO:0000250}.
uniprot
proteins