Dap
entrez
64322
canonical
uniprot
Q9QX67
canonical
ensembl
ENSRNOG00000010747
resolver
ensembl
ENSRNOG00055025172
resolver
ensembl
ENSRNOG00060020280
resolver
ensembl
ENSRNOG00065012892
resolver
ensp
ENSRNOP00000014439
resolver
ensp
ENSRNOP00055035399
resolver
ensp
ENSRNOP00060028918
resolver
ensp
ENSRNOP00065016266
resolver
enst
ENSRNOT00000014439
resolver
enst
ENSRNOT00055043401
resolver
enst
ENSRNOT00060035173
resolver
enst
ENSRNOT00065021084
resolver
genesymbol
Dap
resolver
genesymbol_syn
Rap7a
resolver
uniprot_entry
DAP1_RAT
resolver
amino_acid_sequence
MSSPPEGKLETKAGHPPAVKVAGIRIVQKHPHTGDGKEKKDKDDQEWESTSPPKPTVYISGVIARGDKDFPPAAAQVAHQKPHASMDKHVSPRTQHIQQPRK
uniprot
proteins
function
FUNCTION: Ribosome-binding protein involved in ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation. Acts via its association with eiF5a (EIF5A and EIF5A2) at the polypeptide exit tunnel of the ribosome, preventing mRNA translation. Involved in ribosome hibernation in the mature oocyte by preventing mRNA translation, leading to ribosome inactivation. Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo (By similarity). Also acts as a negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death (By similarity). {ECO:0000250|UniProtKB:P51397, ECO:0000250|UniProtKB:Q9I9N1}.
uniprot
proteins
mass_dalton
11166
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy. {ECO:0000250|UniProtKB:P51397}.
uniprot
proteins
protein_family
DAP-DAPL1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
102
uniprot
proteins