Shroom3
entrez
27428
canonical
uniprot
Q9QXN0
canonical
ensembl
ENSMUSG00000029381
resolver
ensp
ENSMUSP00000108674
resolver
ensp
ENSMUSP00000108677
resolver
ensp
ENSMUSP00000108678
resolver
ensp
ENSMUSP00000153516
resolver
enst
ENSMUST00000113051
resolver
enst
ENSMUST00000113054
resolver
enst
ENSMUST00000113055
resolver
enst
ENSMUST00000225438
resolver
genesymbol
Shroom3
resolver
genesymbol_syn
Kiaa1481
resolver
genesymbol_syn
Shrm
resolver
uniprot
A0A0R4J1H8
resolver
uniprot
A0A286YDQ8
resolver
uniprot
E9QMY5
resolver
uniprot
Q3TNX1
resolver
uniprot
Q6ZPP9
resolver
uniprot
Q99L16
resolver
uniprot
Q9QXM9
resolver
uniprot_entry
A0A0R4J1H8_MOUSE
resolver
uniprot_entry
A0A286YDQ8_MOUSE
resolver
uniprot_entry
E9QMY5_MOUSE
resolver
uniprot_entry
SHRM3_MOUSE
resolver
uniprot_sec
Q3TNX1
resolver
uniprot_sec
Q6ZPP9
resolver
uniprot_sec
Q99L16
resolver
uniprot_sec
Q9QXM9
resolver
amino_acid_sequence
MKTPENLEEPSATPNPSRTPTERFVYLEALLEGGAPWGFTLKGGLERGEPLIISKIEEGGKADSVSSGLQAGDEVIHINEVALSSPRREAVSLVKGSYKTLRLVVRRDVCAAPGHADPGTSKSLSSELLTCSPQHRKATWSGGVKLRLKQRCSEPATRPHSWHTTKFGETQPDVSMMQISQGTMGPPWHQSYHSSSSTSDLSNYDHAYLRRSPDQCSSQGSMESLEPSGGYPPCHLLSPAKSTSSIDQLGHLHNKRDSAYSSFSTSSSIFEYPPPGGSARERSGSMDVISARGGLLEGMRQADIRYVKTVYDTRRGVSSEYEVNPSALLLQGRDAHASADSQGCAKWHSIPRGKGTPSPSWSQQCSGSLETATDNLPQKAGAPLPPTRSDSYAAFRHRERPSSWSSLDQKRFCRPQTNSSGSQKTPFAEDQLHTVPERSPENSPPVKSKHNYTQKAQPGQPLLPTGIYPVPSPEPHFAQVPQPSVSSNGTVYPALVKESGYTAAQGTCNKMATLDENGNQNEASRPGFAFCQPLEHNSVTPVEKRPEPTAKYIYKVHFSSVPENEDSSLKRHITPPHGHSPYPSERKNIHGGSRACSNHHSLSSPQAQALHVGDDRRPSRLSQPWEGDFQEDHNANLRQKVEREGQGQGLSGNSGRTRSAFSSLQNIPESLRRQSNVELGEAQEVHPGGRSKVEDPGRKAGASDIRGYLDRSVSYPRPEGKMNAVDSVHSADSRYEESPAPALPQTSGASQRRLSSSSSAAPQYRKPHCSVLEKVSRIEEREQGRHRPLSVGSSAYGPGYRPGRTGPTPSTSSSDLDDPKAGSVHFSESTEHLRNGEQNPPNGEAKQEEASRPQCSHLIRRAPADGRGPPARGGEPSRPEARLLRSQSTFQLYSEAEREASWSEDRPGTPESPLLDAPFSRAYRNSIKDAQSRVLGATSFRRRDLEPGTPATSRPWRPRPASAHVGMRSPEAAVPSSSPHTPRERHSVTPAAPQAARRGPRRRLTVEQKKRSYSEPEKMNEVGVSEEAEPTPCGPPRPAQPRFSESTVADRRRIFERDGKACSTLSLSGPELKQFQQSALADYIQRKTGKRPTGAACTPEAGLRERAQSAYLQAGPAAPDGPGLASACSLSSLREPEALPRKEHTHPSAADGPQAPRDRSSSFASGRLVGERRRWDPQVPRQLLSGANCEPRGVQRMDGAPGGPPSWGMVAGKAGKSKSAEDLLERSDTLAVPVHVRSRSSPTSDKKGQDVLLREGSNFGFVKDPCCLAGPGPRSLSCSDKGQNELALPLHHPTPCWNGSGCKATVASSAPPESSGAADHLKQRRAPGPRPLSAGMHGHFPDARAASLSSPLPSPVPSASPVPSSYRSQLAMDQQTGQQPPSSPASAVTQPTSPRSPELSSPAYGLGEGMWKRTSLPQRPPPPWVKWAHAVREDGLAEDTLAPEFANLKHYRNQPSRPSSCSTSDPDTPGRISLRISESALQPSPPPRGDYDDEVFMKDLHPKVTSSPTFEALPPPPPPSPPSEEPLVNGTDDFPPPPPPQALCEVLLDGEASTEAGSGPCRIPRVMVTREGHVPGAAHSEGSQIMTATPPQTSAKGSEAESNTPSSASAQPQLNGSPGKQLCPSQTRNLTYEPVERTQDLGKKTHAEPQKTSEDIRTEALAKEIVHQDKSLADILDPDSRMKTTMDLMEGLFPGDASVLMDSGAKRKALDITARRAGCEAKASDHKEAVSVLVNCPAYYSVSAAKAELLNKIKDMPEELQEEEGQEDVNEKKAELIGSLTHKLESLQEAKGSLLTDIKLNNALGEEVEALISELCKPNEFDKYKMFIGDLDKVVNLLLSLSGRLARVENVLRGLGEDASKEERSSLNEKRKVLAGQHEDARELKENLDRRERVVLDILANYLSAEQLQDYQHFVKMKSTLLIEQRKLDDKIKLGQEQVRCLLESLPSDFRPKAGAISLPPALTGHATPGGTSVFGGVFPTLTSPL
uniprot
proteins
function
FUNCTION: Controls cell shape changes in the neuroepithelium during neural tube closure (PubMed:10589677, PubMed:14680628). Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (PubMed:14680628, PubMed:16249236, PubMed:16684770, PubMed:22493320). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). {ECO:0000250|UniProtKB:Q27IV2, ECO:0000269|PubMed:10589677, ECO:0000269|PubMed:14680628, ECO:0000269|PubMed:16249236, ECO:0000269|PubMed:16684770, ECO:0000269|PubMed:22493320}.
uniprot
proteins
mass_dalton
214888
uniprot
proteins
mutagenesis
MUTAGEN 1772..1776; /note="KKAEL->AKARA: Does not affect binding to ROCK1."; MUTAGEN 1838..1841; /note="LLSL->AASA: Loss of dimerization, binding to ROCK1 and ability to trigger apical constriction in cells."; /evidence="ECO:0000269|PubMed:22493320"; MUTAGEN 1840..1846; /note="SLSGRLA->ALEADLE: Reduces binding to ROCK1 and ability to trigger apical constriction in cells."; /evidence="ECO:0000269|PubMed:22493320"; MUTAGEN 1884..1891; /note="LKENLDRR->AAENLDDA: Loss of binding to ROCK1 and ability to trigger apical constriction in cells."; /evidence="ECO:0000269|PubMed:22493320"; MUTAGEN 1921..1928; /note="LLIEQRKL->ALIEQAKA: Loss of dimerization, binding to ROCK1 and ability to trigger apical constriction in cells."; /evidence="ECO:0000269|PubMed:22493320
uniprot
proteins
protein_family
Shroom family
uniprot
proteins
pubmed
10589677
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
14680628
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16249236
uniprot
proteins
pubmed
16615870
uniprot
proteins
pubmed
16684770
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22493320
uniprot
proteins
sequence_length
1986
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000269|PubMed:10589677}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10589677}. Apical cell membrane {ECO:0000269|PubMed:22493320}; Peripheral membrane protein {ECO:0000305}. Note=Colocalizes with F-actin in stress fibers and adherens junctions.
uniprot
proteins