Sv2a
entrez
64051
canonical
uniprot
Q9JIS5
canonical
ensembl
ENSMUSG00000038486
resolver
ensp
ENSMUSP00000037576
resolver
enst
ENSMUST00000035371
resolver
genesymbol
Sv2a
resolver
genesymbol_syn
Kiaa0736
resolver
genesymbol_syn
Sv2
resolver
uniprot
Q80TT0
resolver
uniprot
Q8R0R5
resolver
uniprot_entry
SV2A_MOUSE
resolver
uniprot_sec
Q80TT0
resolver
uniprot_sec
Q8R0R5
resolver
amino_acid_sequence
MEEGFRDRAAFIRGAKDIAKEVKKHAAKKVVKGLDRVQDEYSRRSYSRFEEEDDDDDFPAPADGYYRGEGAQDEEEGGASSDATEGHDEDDEIYEGEYQGIPRAESGGKGERMADGAPLAGVRGGLSDGEGPPGGRGEAQRRKDREELAQQYETILRECGHGRFQWTLYFVLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCFSPEYRRITLMMMGVWFTMSFSYYGLTVWFPDMIRHLQAVDYAARTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLVNSTFLHNKEGCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVLSCVSCFFLSFGNSESAMIALLCLFGGVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALGSSLALKLPETRGQVLQ
uniprot
proteins
function
FUNCTION: Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles.; FUNCTION: (Microbial infection) Receptor for C.botulinum neurotoxin type A (BoNT/A, botA); the toxin probably binds via extracellular loop 4 (PubMed:16543415). {ECO:0000269|PubMed:16543415}.; FUNCTION: (Microbial infection) Possible receptor for C.botulinum neurotoxin type D (BoNT/D, botD); BoNT/D does not bind to extracellular loop 4 as do BoNT/A and BoNT/E (PubMed:21483489). {ECO:0000269|PubMed:21483489}.; FUNCTION: (Microbial infection) Receptor for C.botulinum neurotoxin type E (BoNT/E); the toxin probably binds via extracellular loop 4 (PubMed:18815274). It probably requires glycosylation of Asn-573 (PubMed:18815274). {ECO:0000269|PubMed:18815274, ECO:0000305|PubMed:18815274}.
uniprot
proteins
mass_dalton
82647
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by CK1 of the N-terminal cytoplasmic domain regulates interaction with SYT1. {ECO:0000250}.; PTM: N-glycosylated. {ECO:0000305|PubMed:18815274}.
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
pubmed
10611374
uniprot
proteins
pubmed
10624962
uniprot
proteins
pubmed
11483953
uniprot
proteins
pubmed
12209837
uniprot
proteins
pubmed
12687700
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16436618
uniprot
proteins
pubmed
16543415
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
18815274
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21483489
uniprot
proteins
sequence_length
742
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Presynapse {ECO:0000269|PubMed:12209837}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q02563}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q02563}. Note=Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas (By similarity). Colocalizes with ATP2B1 at photoreceptor synaptic terminals. {ECO:0000250|UniProtKB:Q02563, ECO:0000269|PubMed:12209837}.
uniprot
proteins
transmembrane_region
TRANSMEM 170..190; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 206..226; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 234..254; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 263..283; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 295..315; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 335..355; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 448..468; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 599..619; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 627..647; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 652..672; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 686..708; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 713..731; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins