Msmo1
entrez
140910
canonical
uniprot
O35532
canonical
ensembl
ENSRNOG00000032297
resolver
ensembl
ENSRNOG00055013247
resolver
ensembl
ENSRNOG00060014808
resolver
ensembl
ENSRNOG00065005037
resolver
ensp
ENSRNOP00000043782
resolver
ensp
ENSRNOP00055018452
resolver
ensp
ENSRNOP00060020169
resolver
ensp
ENSRNOP00065005129
resolver
enst
ENSRNOT00000044171
resolver
enst
ENSRNOT00055022720
resolver
enst
ENSRNOT00060025310
resolver
enst
ENSRNOT00065007378
resolver
genesymbol
Msmo1
resolver
genesymbol_syn
Sc4mol
resolver
uniprot_entry
MSMO1_RAT
resolver
amino_acid_sequence
MAMNKSVGLFSSASLAVDYVDSLLPENPLQEPFKNAWVYMLDNYTKFQIATWGSLIVHETIYFLFSLPGFLFQFIPFMRKYKIQKDKPETFEGQWKCLKGILFNHFFIQLPLICGTYYFTEFFNIPYDWERMPRWYFTLARCLGCAVIEDTWHYFLHRLLHHKRIYKYIHKVHHEFQAPFGIEAEYAHPLETLILGTGFFIGIVLLCDHVILLWAWVTMRLLETIDVHSGYDIPLNPLNYIPFYTGARHHDFHHMNFIGNYASTFTWWDRIFGTDVQYHAYTEKMKKLGKKSE
uniprot
proteins
ec_number
1.14.18.9
uniprot
proteins
function
FUNCTION: Catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, which can be subsequently metabolized to cholesterol. {ECO:0000305|PubMed:4394229, ECO:0000305|PubMed:7228857}.
uniprot
proteins
mass_dalton
34964
uniprot
proteins
pathway_participation
PATHWAY: Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 3/6. {ECO:0000305}.; PATHWAY: Steroid biosynthesis; cholesterol biosynthesis. {ECO:0000305|PubMed:4394229, ECO:0000305|PubMed:7228857}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by MARCHF6, leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q15800}.
uniprot
proteins
protein_family
Sterol desaturase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
4394229
uniprot
proteins
pubmed
7228857
uniprot
proteins
pubmed
9284352
uniprot
proteins
sequence_length
293
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 55..75; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 100..120; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 199..219; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins