CARD19
entrez
84270
canonical
uniprot
Q96LW7
canonical
ensembl
ENSG00000165233
resolver
ensp
ENSP00000364613
resolver
ensp
ENSP00000687897
resolver
genesymbol
CARD19
resolver
genesymbol_syn
C9orf89
resolver
hgnc
HGNC:28148
resolver
uniprot
Q5BJH8
resolver
uniprot
Q9BSY2
resolver
uniprot_entry
CAR19_HUMAN
resolver
uniprot_sec
Q5BJH8
resolver
uniprot_sec
Q9BSY2
resolver
amino_acid_sequence
MTDQTYCDRLVQDTPFLTGHGRLSEQQVDRIILQLNRYYPQILTNKEAEKFRNPKASLRVRLCDLLSHLQRSGERDCQEFYRALYIHAQPLHSRLPSRHALRKFHITNHACLVLARGGHPSLPLMAWMSSMTTQVCCSPGLASPLASAPPQRPPSGPEGRVWQAQAVQMLVSVSHFLPLPPSLSHGSFHTAWGILYVHSCPSFSNLIPRGSLHVCVDSNLVPTAAWRS
uniprot
proteins
function
FUNCTION: Plays a role in inhibiting the effects of BCL10-induced activation of NF-kappa-B. May inhibit the phosphorylation of BCL10 in a CARD-dependent manner. {ECO:0000269|PubMed:15637807}.
uniprot
proteins
mass_dalton
25589
uniprot
proteins
mutagenesis
MUTAGEN 17; /note="L->A: Abolishes the NF-kappa-B inhibitory activity."; /evidence="ECO:0000269|PubMed:15637807"; MUTAGEN 65; /note="L->A: Abolishes the NF-kappa-B inhibitory activity."; /evidence="ECO:0000269|PubMed:15637807
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15637807
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
23633586
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
228
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:23633586}. Note=Coexpression with BCL10 induced translocation from nucleus to cytosol.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23633586}; Single-pass membrane protein {ECO:0000269|PubMed:23633586}. Mitochondrion membrane {ECO:0000269|PubMed:23633586}; Single-pass membrane protein {ECO:0000269|PubMed:23633586}.
uniprot
proteins