Ctdspl2
entrez
311368
canonical
uniprot
Q5XIK8
canonical
ensembl
ENSRNOG00000022141
resolver
ensp
ENSRNOP00000033786
resolver
genesymbol
Ctdspl2
resolver
genesymbol_syn
Scp4
resolver
uniprot_entry
CTSL2_RAT
resolver
amino_acid_sequence
MKLRTRKASQQSSPIQTQRTARAKRKYSEVDDSLPSGGEKPSKNETGLLSSIKKFIKGSTPKEERENPSKRSRIERDIDNNLITSTPRTGEKPDKQLSRVRRKSPVNGEAGSYEMTNQHIKQNGKLEDNPCSGSPPRTTLLGTIFSPVFNFFSPANKNGTSGSDSPGQAVEAEEIVKQLDMEQVDEITTSTTSANGAAYSNQAVQVRPSLNNGLEEAEETVTRDIPPLTAPVAPESGYSSAHAEATYEEDWEVFDPYYFIKHVPPLTEEQLNRKPALPLKTRSTPEFSLVLDLDETLVHCSLNELEDAALTFPVLFQDVIYQVYVRLRPFFREFLERMSQMYEIILFTASKKVYADKLLNILDPKKQLVRHRLFREHCVCVQGNYIKDLNILGRDLSKTIIIDNSPQAFAYQLSNGIPIESWFMDKNDNELLKLIPFLEKLVELNEDVRPHIRDRFRLHDLLPPD
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Serine/threonine phosphatase that promotes gluconeogenesis by dephosphorylating FOXO1 and FOXO3A, promoting their nuclear retention and enhancing their transcriptional activity on PCK1 and G6PC1, key enzymes in hepatic gluconeogenesis. Essential for proper embryonic skeletal development by regulating chondrocyte survival through dephosphorylation of FOXO3. By maintaining FOXO3 in its active, dephosphorylated form, inhibits excessive apoptosis of chondrocytes, which is essential for normal endochondral ossification and cartilage formation. {ECO:0000250|UniProtKB:Q8BG15}.
uniprot
proteins
mass_dalton
52783
uniprot
proteins
protein_family
CTDSPL2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
465
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8BG15}.
uniprot
proteins