Tipin
entrez
363076
canonical
uniprot
Q4QR88
canonical
ensembl
ENSRNOG00000043068
resolver
ensembl
ENSRNOG00055024427
resolver
ensembl
ENSRNOG00060019471
resolver
ensembl
ENSRNOG00065006402
resolver
ensp
ENSRNOP00000059833
resolver
ensp
ENSRNOP00000083756
resolver
ensp
ENSRNOP00055034232
resolver
ensp
ENSRNOP00060027599
resolver
ensp
ENSRNOP00065007150
resolver
enst
ENSRNOT00000066973
resolver
enst
ENSRNOT00000112754
resolver
enst
ENSRNOT00055041995
resolver
enst
ENSRNOT00060033708
resolver
enst
ENSRNOT00065009847
resolver
genesymbol
Tipin
resolver
genesymbol_syn
LOC120094818
resolver
uniprot
A0A8I6A0L4
resolver
uniprot_entry
A0A8I6A0L4_RAT
resolver
uniprot_entry
TIPIN_RAT
resolver
amino_acid_sequence
MLEQEENGLFEIPDYEHVEDETFPPFPPPGSPERDPAEAEPDEGSGAPVPVPPKRIVKRNIPKLDATRLTSERGLPALRHVFDKTKFKGKGHEAEDLKTLIRHMEHWAHRLFPKLQFEDFIDRVENLGNKKEVQTCLKRIRLDLPIVHEDFVNNNDEVEETNSLDAAATGFDAFVTSSSDSKRFASEASRNLTEEQQQRIEKNKQLALERRQAKLLSNSQSLENDVTVEESSTGENQEESNGLISADGPHDVPSASTQEEGQLEAEETQLDHPNLD
uniprot
proteins
function
FUNCTION: Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress. {ECO:0000250|UniProtKB:Q9BVW5}.
uniprot
proteins
mass_dalton
31137
uniprot
proteins
protein_family
CSM3 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
276
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BVW5}. Nucleus {ECO:0000250|UniProtKB:Q9BVW5}.
uniprot
proteins