Trpm8
entrez
171382
canonical
uniprot
Q8R4D5
canonical
ensembl
ENSMUSG00000036251
resolver
ensp
ENSMUSP00000036991
resolver
ensp
ENSMUSP00000108739
resolver
ensp
ENSMUSP00000131209
resolver
enst
ENSMUST00000040210
resolver
enst
ENSMUST00000113114
resolver
enst
ENSMUST00000171176
resolver
genesymbol
Trpm8
resolver
genesymbol_syn
Ltrpc6
resolver
genesymbol_syn
Trpp8
resolver
uniprot
E9Q165
resolver
uniprot
Q148W9
resolver
uniprot_entry
TRPM8_MOUSE
resolver
uniprot_sec
E9Q165
resolver
uniprot_sec
Q148W9
resolver
activity_regulation
ACTIVITY REGULATION: Activated by cold temperatures and by both natural and synthetic cooling compounds such as menthol and icilin (PubMed:11893340, PubMed:12654248, PubMed:15190109, PubMed:17481391). Activation of the channel requires the presence of PI(4,5)P2; PI(4,5)P2 is necessary to gate the channel (By similarity). Activated by intracellular Ca(2+) (By similarity). {ECO:0000250|UniProtKB:Q7Z2W7, ECO:0000269|PubMed:11893340, ECO:0000269|PubMed:12654248, ECO:0000269|PubMed:15190109, ECO:0000269|PubMed:17481391}.
uniprot
proteins
amino_acid_sequence
MSFEGARLSMRSRRNGTMGSTRTLYSSVSRSTDVSYSDSDLVNFIQANFKKRECVFFTRDSKAMENICKCGYAQSQHIEGTQINQNEKWNYKKHTKEFPTDAFGDIQFETLGKKGKYLRLSCDTDSETLYELLTQHWHLKTPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRNSEENIVAIGIAAWGMVSNRDTLIRSCDDEGHFSAQYIMDDFTRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTSQDSNYGGKIPIVCFAQGGGRETLKAINTSVKSKIPCVVVEGSGQIADVIASLVEVEDVLTSSMVKEKLVRFLPRTVSRLPEEEIESWIKWLKEILESSHLLTVIKMEEAGDEIVSNAISYALYKAFSTNEQDKDNWNGQLKLLLEWNQLDLASDEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLENGLNLQKFLTNEVLTELFSTHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRSFWKEDRSSREDLDVELHDASLTTRHPLQALFIWAILQNKKELSKVIWEQTKGCTLAALGASKLLKTLAKVKNDINAAGESEELANEYETRAVELFTECYSNDEDLAEQLLVYSCEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGLVSFRKKPIDKHKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHTPELILYALVFVLFCDEVRQWYMNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFRSVIYEPYLAMFGQVPSDVDSTTYDFSHCTFSGNESKPLCVELDEHNLPRFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGIVQENNDQVWKFQRYFLVQEYCNRLNIPFPFVVFAYFYMVVKKCFKCCCKEKNMESNACCFRNEDNETLAWEGVMKENYLVKINTKANDNSEEMRHRFRQLDSKLNDLKSLLKEIANNIK
uniprot
proteins
function
FUNCTION: Non-selective ion channel permeable to monovalent and divalent cations, including Na(+), K(+), and Ca(2+), with higher permeability for Ca(2+) (PubMed:11893340, PubMed:12654248, PubMed:15190109). Activated by multiple factors, such as temperature, voltage, pressure, and changes in osmolality (PubMed:12654248, PubMed:15190109, PubMed:25998021). Activated by cool temperatures (<23-28 degrees Celsius) and by chemical ligands evoking a sensation of coolness, such as menthol and icilin, therefore plays a central role in the detection of environmental cold temperatures (PubMed:12654248, PubMed:15190109, PubMed:17481391). TRPM8 is a voltage-dependent channel; its activation by cold or chemical ligands shifts its voltage thresholds towards physiological membrane potentials, leading to the opening of the channel (By similarity). In addition to its critical role in temperature sensing, regulates basal tear secretion by sensing evaporation-induced cooling and changes in osmolality (PubMed:25998021). {ECO:0000250|UniProtKB:Q7Z2W7, ECO:0000269|PubMed:11893340, ECO:0000269|PubMed:12654248, ECO:0000269|PubMed:15190109, ECO:0000269|PubMed:17481391, ECO:0000269|PubMed:25998021}.
uniprot
proteins
mass_dalton
127710
uniprot
proteins
mutagenesis
MUTAGEN 821; /note="N->Q: No effect on glycosylation or ability to form functional channels."; /evidence="ECO:0000269|PubMed:17015441"; MUTAGEN 929; /note="C->A: Abolishes ion channel activity. No effect on cell surface expression. Reduced glycosylation."; /evidence="ECO:0000269|PubMed:17015441"; MUTAGEN 934; /note="N->D: Slightly reduced ion channel sensitivity to cold stimuli. No significant effect on ion channel sensitivity to menthol plus cold stimuli."; /evidence="ECO:0000269|PubMed:17015441, ECO:0000269|PubMed:19176480, ECO:0000269|PubMed:22493431"; MUTAGEN 934; /note="N->K: Reduced ion channel sensitivity to cold stimuli or menthol plus cold stimuli."; /evidence="ECO:0000269|PubMed:17015441, ECO:0000269|PubMed:19176480, ECO:0000269|PubMed:22493431"; MUTAGEN 934; /note="N->Q: Abolishes glycosylation. Shifts threshold of temperature activation from 26.5 to 24 degrees Celsius. Reduced cell surface expression, association with lipid rafts and response to cold."; /evidence="ECO:0000269|PubMed:17015441, ECO:0000269|PubMed:19176480, ECO:0000269|PubMed:22493431"; MUTAGEN 940; /note="C->A: Abolishes ion channel activity. No effect on cell surface expression. Reduced glycosylation."; /evidence="ECO:0000269|PubMed:17015441
uniprot
proteins
post_translational_modification
PTM: N-glycosylation is not essential for but facilitates cell surface expression, multimerization, association with lipid rafts and ion channel activity. {ECO:0000269|PubMed:17015441, ECO:0000269|PubMed:19176480}.
uniprot
proteins
protein_family
LTrpC subfamily
uniprot
proteins
protein_family
TRPM8 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
pubmed
11893340
uniprot
proteins
pubmed
12654248
uniprot
proteins
pubmed
15190109
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17015441
uniprot
proteins
pubmed
17481391
uniprot
proteins
pubmed
19176480
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22493431
uniprot
proteins
pubmed
25998021
uniprot
proteins
pubmed
35662242
uniprot
proteins
pubmed
36227998
uniprot
proteins
sequence_length
1104
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17015441}; Multi-pass membrane protein {ECO:0000269|PubMed:35662242}. Membrane raft {ECO:0000269|PubMed:19176480}. Note=Lipid raft association modulates TRPM8 channel activity. {ECO:0000269|PubMed:19176480}.
uniprot
proteins
transmembrane_region
TRANSMEM 734..758; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:35662242, ECO:0007744|PDB:7WRE"; TRANSMEM 766..789; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:35662242, ECO:0007744|PDB:7WRE"; TRANSMEM 797..817; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:35662242, ECO:0007744|PDB:7WRE"; TRANSMEM 823..848; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:35662242, ECO:0007744|PDB:7WRE"; TRANSMEM 854..890; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:35662242, ECO:0007744|PDB:7WRE"; TRANSMEM 954..984; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:35662242, ECO:0007744|PDB:7WRE
uniprot
proteins