Gata1
entrez
25172
canonical
uniprot
P43429
canonical
ensembl
ENSRNOG00000047663
resolver
ensembl
ENSRNOG00055027943
resolver
ensembl
ENSRNOG00060023142
resolver
ensembl
ENSRNOG00065011306
resolver
ensp
ENSRNOP00000067336
resolver
ensp
ENSRNOP00055039763
resolver
ensp
ENSRNOP00060033058
resolver
ensp
ENSRNOP00065014011
resolver
enst
ENSRNOT00000075082
resolver
enst
ENSRNOT00055048355
resolver
enst
ENSRNOT00060040056
resolver
enst
ENSRNOT00065018341
resolver
genesymbol
Gata1
resolver
uniprot_entry
GATA1_RAT
resolver
amino_acid_sequence
MDFPGLGALGTSEPLPQFVDSALVSSTSDSAGFFSSGPESLDTASSSTSPNAATAAATALAYYREAEAYRHSPVFQVYPLLNSMEGIPGSSPYASWAYSKTALYPASTVCPSHEDAPSQTLEDPDGKNNNTFLETLKTERLSPDLLTLGTALPTSLPVTSSAYGGADFPSPFFSPTGSPLSSAAYSSPKFHGSLPLAPCEARECVNCGATATPLWRRDRTGHYLCNACGLYHKMNGQNRPLIRPKKRMIVSKRAGTQCTNCQTTTTTLWRRNASGDPVCNACGLYYKLHQVNRPLTMRKDGIQTRNRKASGKGKKKRGSSLAGAGAAEGPAGGFMVVAGGSSSGNCGEVAPGLTLGTAGTAHLYQGLGPVVLSGPVSHLMSFPGPLLGSPTASFPTGPVPTTTSTSVVSPLSS
uniprot
proteins
function
FUNCTION: Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS. {ECO:0000250|UniProtKB:P15976}.
uniprot
proteins
mass_dalton
42871
uniprot
proteins
post_translational_modification
PTM: Highly phosphorylated on serine residues. Phosphorylation on Ser-310 is enhanced on erythroid differentiation. Phosphorylation on Ser-142 promotes sumoylation on Lys-137 (By similarity). {ECO:0000250}.; PTM: Sumoylation on Lys-137 is enhanced by phosphorylation on Ser-142 and by interaction with PIAS4. Sumoylation with SUMO1 has no effect on transcriptional activity (By similarity). {ECO:0000250}.; PTM: Acetylated at 2 conserved lysine-rich motifs by CREBBP in vitro. Acetylation does not affect DNA-binding in vitro but is essential to induce erythroid differentiation and for binding chromatin in vivo. Acetylated on Lys-233, Lys-245 Lys-246 by EP300 (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
7957872
uniprot
proteins
sequence_length
413
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins