Flt3
entrez
14255
canonical
uniprot
Q00342
canonical
ensembl
ENSMUSG00000042817
resolver
ensp
ENSMUSP00000039041
resolver
enst
ENSMUST00000049324
resolver
genesymbol
Flt3
resolver
genesymbol_syn
Flk-2
resolver
genesymbol_syn
Flt-3
resolver
uniprot
F6Z929
resolver
uniprot
Q3TQF1
resolver
uniprot
Q3UEW6
resolver
uniprot_entry
F6Z929_MOUSE
resolver
uniprot_entry
FLT3_MOUSE
resolver
uniprot_entry
Q3TQF1_MOUSE
resolver
uniprot_entry
Q3UEW6_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Present in an inactive conformation in the absence of bound ligand. FLT3LG binding leads to dimerization and activation by autophosphorylation. {ECO:0000269|PubMed:21516120}.
uniprot
proteins
amino_acid_sequence
MRALAQRSDRRLLLLVVLSVMILETVTNQDLPVIKCVLISHENNGSSAGKPSSYRMVRGSPEDLQCTPRRQSEGTVYEAATVEVAESGSITLQVQLATPGDLSCLWVFKHSSLGCQPHFDLQNRGIVSMAILNVTETQAGEYLLHIQSEAANYTVLFTVNVRDTQLYVLRRPYFRKMENQDALLCISEGVPEPTVEWVLCSSHRESCKEEGPAVVRKEEKVLHELFGTDIRCCARNALGRESTKLFTIDLNQAPQSTLPQLFLKVGEPLWIRCKAIHVNHGFGLTWELEDKALEEGSYFEMSTYSTNRTMIRILLAFVSSVGRNDTGYYTCSSSKHPSQSALVTILEKGFINATSSQEEYEIDPYEKFCFSVRFKAYPRIRCTWIFSQASFPCEQRGLEDGYSISKFCDHKNKPGEYIFYAENDDAQFTKMFTLNIRKKPQVLANASASQASCSSDGYPLPSWTWKKCSDKSPNCTEEIPEGVWNKKANRKVFGQWVSSSTLNMSEAGKGLLVKCCAYNSMGTSCETIFLNSPGPFPFIQDNISFYATIGLCLPFIVVLIVLICHKYKKQFRYESQLQMIQVTGPLDNEYFYVDFRDYEYDLKWEFPRENLEFGKVLGSGAFGRVMNATAYGISKTGVSIQVAVKMLKEKADSCEKEALMSELKMMTHLGHHDNIVNLLGACTLSGPVYLIFEYCCYGDLLNYLRSKREKFHRTWTEIFKEHNFSFYPTFQAHSNSSMPGSREVQLHPPLDQLSGFNGNSIHSEDEIEYENQKRLAEEEEEDLNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDILSDSSYVVRGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQSGFKMEQPFYATEGIYFVMQSCWAFDSRKRPSFPNLTSFLGCQLAEAEEAMYQNMGGNVPEHPSIYQNRRPLSREAGSEPPSPQAQVKIHRERS
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways. {ECO:0000269|PubMed:18469816, ECO:0000269|PubMed:19286519, ECO:0000269|PubMed:20457904, ECO:0000269|PubMed:21516120, ECO:0000269|PubMed:8920882}.
uniprot
proteins
mass_dalton
113496
uniprot
proteins
mutagenesis
MUTAGEN 645; /note="K->A: Loss of kinase activity; no effect on FIZ1-binding."; /evidence="ECO:0000269|PubMed:10409713
uniprot
proteins
post_translational_modification
PTM: N-glycosylated, contains complex N-glycans with sialic acid. {ECO:0000250}.; PTM: Autophosphorylated on several tyrosine residues in response to FLT3LG binding. FLT3LG binding also increases phosphorylation of mutant kinases that are constitutively activated. Dephosphorylated by PTPRJ/DEP-1, PTPN1, PTPN6/SHP-1, and to a lesser degree by PTPN12. Dephosphorylation is important for export from the endoplasmic reticulum and location at the cell membrane (By similarity). {ECO:0000250}.; PTM: Rapidly ubiquitinated by UBE2L6 and the E3 ubiquitin-protein ligase SIAH1 after autophosphorylation, leading to its proteasomal degradation. {ECO:0000250}.
uniprot
proteins
protein_family
CSF-1/PDGF receptor subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
10409713
uniprot
proteins
pubmed
1648448
uniprot
proteins
pubmed
1656368
uniprot
proteins
pubmed
18469816
uniprot
proteins
pubmed
19286519
uniprot
proteins
pubmed
20457904
uniprot
proteins
pubmed
21516120
uniprot
proteins
pubmed
23418353
uniprot
proteins
pubmed
7621074
uniprot
proteins
pubmed
8384358
uniprot
proteins
pubmed
8920882
uniprot
proteins
sequence_length
1000
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Endoplasmic reticulum lumen {ECO:0000250}. Note=Constitutively activated mutant forms with internal tandem duplications are less efficiently transported to the cell surface and a significant proportion is retained in an immature form in the endoplasmic reticulum lumen. The activated kinase is rapidly targeted for degradation (By similarity). {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 545..564; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins