Rpap2
entrez
305120
canonical
uniprot
Q5I0E6
canonical
ensembl
ENSRNOG00000023484
resolver
ensp
ENSRNOP00000002815
resolver
ensp
ENSRNOP00000080489
resolver
ensp
ENSRNOP00000081066
resolver
ensp
ENSRNOP00000106193
resolver
enst
ENSRNOT00000002815
resolver
enst
ENSRNOT00000135453
resolver
genesymbol
Rpap2
resolver
uniprot
A0A8L2PZW5
resolver
uniprot
A0ABK0L7M6
resolver
uniprot
D4A5J9
resolver
uniprot
D4A672
resolver
uniprot_entry
A0A8L2PZW5_RAT
resolver
uniprot_entry
A0ABK0L7M6_RAT
resolver
uniprot_entry
RPAP2_RAT
resolver
uniprot_sec
D4A5J9
resolver
uniprot_sec
D4A672
resolver
amino_acid_sequence
MADSAVPYSLGPSARASSTHRVATGTKQTSALKRRDASKRQAELEAALQRKVESERRAVRLVEQLLEENITEEFLKECGMFITPAHYSDVVDERAIIKLCGYPLCQKKLGVIPKQKYRISTKTNKVYDITERKSFCSNFCYKASKFFEAQIPKTPVWVREEERPPEFQLLKKGQSGCSGEVVQFFRDAVTAADVDAYGAFDAQCEPASSSTWSERASDERASDEEGPGFVSSLLPGNRPKAVGTKPQPHRQSSTVKKKAAQKMTSKHGEQTVSEVTEQLSNCRLDSQEKVATCKLPAKKENTQISSPGPLCDRLNTSTVSENKHSVSQVTLVGISKKSAEHFRSKFAKSNPGSGSASGLVQVRPEVAKANLLRVLKDTLTEWKTDETLKFLYGQDHGSVCLQPSAASGPDEELDEDDISCQAQNTLDETLPFRGSDTAIKPLPSYESLKKETEMLNLRVREFYRGRCVLNEDSTKSQDSKENELQRDPSFPLIDSSSQNQIRRRIVLEKLSKVLPGLLGPLQITMGDIYTELKNLVQTFRLSNRNIIHKPVEWTLIAVVLLSLLTPILGIQKHSPKNVVFTQFIATLLTELHLKCEDLENLAMIFRTSC
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes (By similarity). Downstream of EIF2AK3/PERK, dephosphorylates ERN1, a sensor for the endoplasmic reticulum unfolded protein response (UPR), to abort failed ER-stress adaptation and trigger apoptosis (By similarity). {ECO:0000250|UniProtKB:Q8IXW5}.
uniprot
proteins
mass_dalton
67892
uniprot
proteins
protein_family
RPAP2 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
609
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Shuttles between the cytoplasm and the nucleus in a CRM1-dependent manner. {ECO:0000250}.
uniprot
proteins