Fzd9
entrez
266608
canonical
uniprot
Q8K4C8
canonical
ensembl
ENSRNOG00000001452
resolver
ensembl
ENSRNOG00055000406
resolver
ensembl
ENSRNOG00060012483
resolver
ensembl
ENSRNOG00065001814
resolver
ensp
ENSRNOP00000102705
resolver
ensp
ENSRNOP00055000571
resolver
ensp
ENSRNOP00060016682
resolver
ensp
ENSRNOP00065001696
resolver
enst
ENSRNOT00000170154
resolver
enst
ENSRNOT00055000718
resolver
enst
ENSRNOT00060021146
resolver
enst
ENSRNOT00065002423
resolver
genesymbol
Fzd9
resolver
uniprot_entry
FZD9_RAT
resolver
amino_acid_sequence
MAVPPLLRGALLLWQLLATGGAALEIGRFDPERGRGPAPCQAMEIPMCRGIGYNLTRMPNLLGHTSQGEAAAQLAEFSPLVQYGCHSHLRFFLCSLYAPMCTDQVSTPIPACRPMCEQARLRCAPIMEQFNFGWPDSLDCARLPTRNDPHALCMEAPENATAGPTEPHKGLGMLPVAPRPARPPGDSAPGPGSGGTCDNPEKFQYVEKSRSCAPRCGPGVEVFWSRRDKDFALVWMAVWSALCFFSTAFTVFTFLLEPHRFQYPERPIIFLSMCYNVYSLAFLIRAVAGAQSVACDQEAGALYVIQEGLENTGCTLVFLLLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEAHGSYFHMAAWGLPALKTIVVLTLRKVAGDELTGLCYVASMDPAALTGFVLVPLSCYLVLGTSFLLTGFVALFHIRKIMKTGGTNTEKLEKLMVKIGVFSILYTVPATCVIVCYVYERLNMDFWRLRATEQPCTAAAVPGGRRDCSLPGGSVPTVAVFMLKIFMSLVVGITSGVWVWSSKTFQTWQSLCYRKMAAGRARAKACRTPGGYGRGTHCHYKAPTVVLHMTKTDPSLENPTHL
uniprot
proteins
function
FUNCTION: Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (PubMed:12138115). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (By similarity). May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process (By similarity). During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling (By similarity). {ECO:0000250|UniProtKB:O00144, ECO:0000250|UniProtKB:Q9R216, ECO:0000269|PubMed:12138115}.
uniprot
proteins
mass_dalton
64965
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. {ECO:0000250}.
uniprot
proteins
protein_family
G protein-coupled receptor Fz/Smo family
uniprot
proteins
pubmed
12138115
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
16670314
uniprot
proteins
sequence_length
592
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12138115}; Multi-pass membrane protein {ECO:0000255}. Note=Relocalizes DVL1 to the cell membrane leading to phosphorylation of DVL1 and AXIN1 relocalization to the cell membrane. {ECO:0000269|PubMed:12138115}.
uniprot
proteins
transmembrane_region
TRANSMEM 231..251; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 268..288; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 315..335; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 357..377; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 402..422; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 449..469; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 510..530; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins