PPP4C
entrez
5531
canonical
uniprot
P60510
canonical
ensembl
ENSG00000149923
resolver
ensp
ENSP00000279387
resolver
ensp
ENSP00000455995
resolver
ensp
ENSP00000457089
resolver
ensp
ENSP00000571367
resolver
ensp
ENSP00000571369
resolver
ensp
ENSP00000571370
resolver
ensp
ENSP00000571372
resolver
ensp
ENSP00000571377
resolver
enst
ENST00000279387
resolver
enst
ENST00000561610
resolver
enst
ENST00000901308
resolver
enst
ENST00000901310
resolver
enst
ENST00000901311
resolver
enst
ENST00000901313
resolver
enst
ENST00000901318
resolver
genesymbol
PPP4C
resolver
genesymbol_syn
PPP4
resolver
genesymbol_syn
PPX
resolver
hgnc
HGNC:9319
resolver
uniprot
A0A024R625
resolver
uniprot
P33172
resolver
uniprot_entry
A0A024R625_HUMAN
resolver
uniprot_entry
PP4C_HUMAN
resolver
uniprot_sec
P33172
resolver
amino_acid_sequence
MAEISDLDRQIEQLRRCELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPEDTTGWGVSPRGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEAAPQETRGIPSKKPVADYFL
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin. {ECO:0000250, ECO:0000269|PubMed:11698396, ECO:0000269|PubMed:12668731, ECO:0000269|PubMed:12934076, ECO:0000269|PubMed:1336397, ECO:0000269|PubMed:15805470, ECO:0000269|PubMed:18347064, ECO:0000269|PubMed:18487071, ECO:0000269|PubMed:18614045, ECO:0000269|PubMed:18758438, ECO:0000269|PubMed:20154705}.
uniprot
proteins
mass_dalton
35080
uniprot
proteins
mutagenesis
MUTAGEN 39; /note="E->K: Diminishes interaction with PPP4R4."; /evidence="ECO:0000269|PubMed:18715871"; MUTAGEN 64; /note="E->K: Abolishes interaction with PPP4R4."; /evidence="ECO:0000269|PubMed:18715871"; MUTAGEN 76; /note="N->D: Diminishes interaction with PPP4R4."; /evidence="ECO:0000269|PubMed:18715871"; MUTAGEN 82; /note="D->A: Loss of activity."; /evidence="ECO:0000269|PubMed:20154705"; MUTAGEN 107; /note="R->E: Diminishes interaction with PPP4R4."; /evidence="ECO:0000269|PubMed:18715871"; MUTAGEN 277; /note="E->K: Abolishes interaction with PPP4R4; no effect on interaction with PPP4R1 and PPP4R2."; /evidence="ECO:0000269|PubMed:18715871"; MUTAGEN 307; /note="L->A: Unable to dephosphorylate 53BP1 and KAR1, loss of DSB repair activity."; /evidence="ECO:0000269|PubMed:25130464
uniprot
proteins
post_translational_modification
PTM: Methylation at the C-terminal Leu-307 is critical for interactions with regulatory subunits and functions in DNA repair. {ECO:0000269|PubMed:25130464}.; PTM: Ubiquitinated by the SCF(FBXO42) complex; leading to proteasomal degradation. {ECO:0000269|PubMed:41484364}.
uniprot
proteins
protein_family
PP-4 (PP-X) subfamily
uniprot
proteins
protein_family
PPP phosphatase family
uniprot
proteins
pubmed
11698396
uniprot
proteins
pubmed
12668731
uniprot
proteins
pubmed
12934076
uniprot
proteins
pubmed
1336397
uniprot
proteins
pubmed
15331607
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15805470
uniprot
proteins
pubmed
16085932
uniprot
proteins
pubmed
18347064
uniprot
proteins
pubmed
18487071
uniprot
proteins
pubmed
18614045
uniprot
proteins
pubmed
18715871
uniprot
proteins
pubmed
18758438
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20154705
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
25130464
uniprot
proteins
pubmed
41484364
uniprot
proteins
pubmed
9837938
uniprot
proteins
sequence_length
307
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
uniprot
proteins