GALNT11
entrez
63917
canonical
uniprot
Q8NCW6
canonical
ensembl
ENSG00000178234
resolver
ensp
ENSP00000395122
resolver
ensp
ENSP00000410093
resolver
ensp
ENSP00000550770
resolver
ensp
ENSP00000550771
resolver
ensp
ENSP00000550772
resolver
ensp
ENSP00000550774
resolver
ensp
ENSP00000550775
resolver
ensp
ENSP00000550776
resolver
ensp
ENSP00000550785
resolver
ensp
ENSP00000550789
resolver
ensp
ENSP00000550790
resolver
ensp
ENSP00000550792
resolver
ensp
ENSP00000550794
resolver
ensp
ENSP00000593158
resolver
ensp
ENSP00000593163
resolver
ensp
ENSP00000636920
resolver
ensp
ENSP00000674631
resolver
ensp
ENSP00000784246
resolver
genesymbol
GALNT11
resolver
hgnc
HGNC:19875
resolver
uniprot
B3KWF4
resolver
uniprot
B7Z5G5
resolver
uniprot
Q6PCD1
resolver
uniprot
Q9H6C2
resolver
uniprot
Q9H6Z5
resolver
uniprot
Q9UDR8
resolver
uniprot_entry
B7Z5G5_HUMAN
resolver
uniprot_entry
GLT11_HUMAN
resolver
uniprot_sec
B3KWF4
resolver
uniprot_sec
Q6PCD1
resolver
uniprot_sec
Q9H6C2
resolver
uniprot_sec
Q9H6Z5
resolver
uniprot_sec
Q9UDR8
resolver
amino_acid_sequence
MGSVTVRYFCYGCLFTSATWTVLLFVYFNFSEVTQPLKNVPVKGSGPHGPSPKKFYPRFTRGPSRVLEPQFKANKIDDVIDSRVEDPEEGHLKFSSELGMIFNERDQELRDLGYQKHAFNMLISDRLGYHRDVPDTRNAACKEKFYPPDLPAASVVICFYNEAFSALLRTVHSVIDRTPAHLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVIRNTKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVVCPVIDIISADTLAYSSSPVVRGGFNWGLHFKWDLVPLSELGRAEGATAPIKSPTMAGGLFAMNRQYFHELGQYDSGMDIWGGENLEISFRIWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKEQYFSLRPDLKTKSYGNISERVELRKKLGCKSFKWYLDNVYPEMQISGSHAKPQQPIFVNRGPKRPKVLQRGRLYHLQTNKCLVAQGRPSQKGGLVVLKACDYSDPNQIWIYNEEHELVLNSLLCLDMSETRSSDPPRLMKCHGSGGSQQWTFGKNNRLYQVSVGQCLRAVDPLGQKGSVAMAICDGSSSQQWHLEG
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in GALNT11 may be a cause of heterotaxy, a congenital heart disease resulting from abnormalities in left-right (LR) body patterning. {ECO:0000269|PubMed:21282601}.
uniprot
proteins
ec_number
2.4.1.41
uniprot
proteins
function
FUNCTION: Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO). {ECO:0000269|PubMed:11925450, ECO:0000269|PubMed:16207894, ECO:0000269|PubMed:24226769}.
uniprot
proteins
mass_dalton
68919
uniprot
proteins
mutagenesis
MUTAGEN 247; /note="H->A: Abolishes glycosyltransferase activity and ability to rescue left-right patterning defects induced by galnt11 knockdown in X.tropicalis."; /evidence="ECO:0000269|PubMed:24226769
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation.
uniprot
proteins
protein_family
GalNAc-T subfamily
uniprot
proteins
protein_family
Glycosyltransferase 2 family
uniprot
proteins
pubmed
11925450
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16207894
uniprot
proteins
pubmed
20547088
uniprot
proteins
pubmed
21282601
uniprot
proteins
pubmed
24226769
uniprot
proteins
sequence_length
608
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:11925450}; Single-pass type II membrane protein {ECO:0000269|PubMed:11925450}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..29; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins