LIN54
entrez
132660
canonical
uniprot
Q6MZP7
canonical
ensembl
ENSG00000189308
resolver
ensp
ENSP00000341947
resolver
ensp
ENSP00000398265
resolver
ensp
ENSP00000407139
resolver
ensp
ENSP00000421045
resolver
ensp
ENSP00000423475
resolver
ensp
ENSP00000425844
resolver
ensp
ENSP00000527219
resolver
ensp
ENSP00000527222
resolver
genesymbol
LIN54
resolver
genesymbol_syn
CXCDC1
resolver
genesymbol_syn
KIAA2037
resolver
hgnc
HGNC:25397
resolver
uniprot
Q32M68
resolver
uniprot
Q32M69
resolver
uniprot
Q6N071
resolver
uniprot
Q76B60
resolver
uniprot_entry
LIN54_HUMAN
resolver
uniprot_sec
Q32M68
resolver
uniprot_sec
Q32M69
resolver
uniprot_sec
Q6N071
resolver
uniprot_sec
Q76B60
resolver
amino_acid_sequence
MEVVPAEVNSLLPEEIMDTGITLVDDDSIEAVIVSSPIPMETELEEIVNINSTGDSTATPISTEPITVYSNHTNQVAVNTTITKADSNTTVKPAFPSGLQKLGAQTPVTISANQIILNKVSQTSDLKLGNQTLKPDGQKLILTTLGKSGSPIVLALPHSQLPQAQKVTTQAQSGDAKLPPQQIKVVTIGGRPEVKPVIGVSALTPGSQLINTTTQPSVLQTQQLKTVQIAKKPRTPTSGPVITKLIFAKPINSKAVTGQTTQVSPPVIAGRVLSQSTPGTPSKTITISESGVIGSTLNSTTQTPNKIAISPLKSPNKAVKSTVQTITVGGVSTSQFKTIIPLATAPNVQQIQVPGSKFHYVRLVTATSASSSTQPVSQNPSTNTQPLQQAKPVVVNTTPVRMSVPIVSAQAVKQVVPKPINPTSQIVTTSQPQQRLIMPATPLPQIQPNLTNLPPGTVLAPAPGTGNVGYAVLPAQYVTQLQQSSYVSIASNSTFTGTSGIQTQARLPFNGIIPSESASRPRKPCNCTKSLCLKLYCDCFANGEFCNNCNCTNCYNNLEHENERQKAIKACLDRNPEAFKPKIGKGKEGESDRRHSKGCNCKRSGCLKNYCECYEAKIMCSSICKCIGCKNFEESPERKTLMHLADAAEVRVQQQTAAKTKLSSQISDLLTRPTPALNSGGGKLPFTFVTKEVAEATCNCLLAQAEQADKKGKSKAAAERMILEEFGRCLMSVINSAGKAKSDPCAMNC
uniprot
proteins
function
FUNCTION: Component of the DREAM complex, a multiprotein complex that can both act as a transcription activator or repressor depending on the context (PubMed:17531812, PubMed:17671431). In G0 phase, the complex binds to more than 800 promoters and is required for repression of E2F target genes (PubMed:17531812, PubMed:17671431). In S phase, the complex selectively binds to the promoters of G2/M genes whose products are required for mitosis and participates in their cell cycle dependent activation (PubMed:17531812, PubMed:17671431). In the complex, acts as a DNA-binding protein that binds the promoter of CDK1 in a sequence-specific manner (PubMed:19725879). Specifically recognizes the consensus motif 5'-TTYRAA-3' in target DNA (PubMed:27465258). {ECO:0000269|PubMed:17531812, ECO:0000269|PubMed:17671431, ECO:0000269|PubMed:19725879, ECO:0000269|PubMed:27465258}.
uniprot
proteins
mass_dalton
79494
uniprot
proteins
mutagenesis
MUTAGEN 525; /note="C->Y: Abolishes DNA-binding to the CDK1 promoter; when associated with Y-527."; /evidence="ECO:0000269|PubMed:19725879"; MUTAGEN 527; /note="C->Y: Abolishes DNA-binding to the CDK1 promoter; when associated with Y-525."; /evidence="ECO:0000269|PubMed:19725879"; MUTAGEN 536; /note="Y->A,F,R: Loss of DNA-binding."; /evidence="ECO:0000269|PubMed:27465258"; MUTAGEN 610; /note="Y->A,F,R: Loss of DNA-binding."; /evidence="ECO:0000269|PubMed:27465258
uniprot
proteins
protein_family
Lin-54 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17531812
uniprot
proteins
pubmed
17671431
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19725879
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
27465258
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
749
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins