CDK10
entrez
8558
canonical
uniprot
Q15131
canonical
ensembl
ENSG00000185324
resolver
ensp
ENSP00000338673
resolver
ensp
ENSP00000424415
resolver
ensp
ENSP00000521939
resolver
ensp
ENSP00000521941
resolver
ensp
ENSP00000521943
resolver
ensp
ENSP00000661992
resolver
ensp
ENSP00000702321
resolver
ensp
ENSP00000755316
resolver
ensp
ENSP00000755322
resolver
genesymbol
CDK10
resolver
hgnc
HGNC:1770
resolver
uniprot
A8K370
resolver
uniprot
A8K8I6
resolver
uniprot
A8MXU6
resolver
uniprot
B3KQJ3
resolver
uniprot
B7Z420
resolver
uniprot
B7Z537
resolver
uniprot
D3DX82
resolver
uniprot
D3DX83
resolver
uniprot
Q0VGZ7
resolver
uniprot
Q15130
resolver
uniprot
Q6PJC0
resolver
uniprot_entry
B7Z537_HUMAN
resolver
uniprot_entry
CDK10_HUMAN
resolver
uniprot_sec
A8K370
resolver
uniprot_sec
A8K8I6
resolver
uniprot_sec
A8MXU6
resolver
uniprot_sec
B3KQJ3
resolver
uniprot_sec
B7Z420
resolver
uniprot_sec
D3DX82
resolver
uniprot_sec
D3DX83
resolver
uniprot_sec
Q0VGZ7
resolver
uniprot_sec
Q15130
resolver
uniprot_sec
Q6PJC0
resolver
amino_acid_sequence
MAEPDLECEQIRLKCIRKEGFFTVPPEHRLGRCRSVKEFEKLNRIGEGTYGIVYRARDTQTDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYCEQDLASLLENMPTPFSEAQVKCIVLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTADFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHRPLLPGTSEIHQIDLIVQLLGTPSENIWPGFSKLPLVGQYSLRKQPYNNLKHKFPWLSEAGLRLLHFLFMYDPKKRATAGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPATSEGQSKRCKP
uniprot
proteins
disease_involvement
DISEASE: Al Kaissi syndrome (ALKAS) [MIM:617694]: An autosomal recessive developmental disorder characterized by growth retardation, spine malformation, facial dysmorphisms, and developmental delay. {ECO:0000269|PubMed:28886341}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.11.22
uniprot
proteins
function
FUNCTION: Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) (PubMed:24218572). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling (PubMed:27104747). {ECO:0000269|PubMed:24218572, ECO:0000269|PubMed:27104747}.
uniprot
proteins
mass_dalton
41038
uniprot
proteins
protein_family
CDC2/CDKX subfamily
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10036189
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
24218572
uniprot
proteins
pubmed
27104747
uniprot
proteins
pubmed
28886341
uniprot
proteins
pubmed
8084611
uniprot
proteins
pubmed
8208557
uniprot
proteins
sequence_length
360
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:27104747}.
uniprot
proteins