ADAM11
entrez
4185
canonical
uniprot
O75078
canonical
ensembl
ENSG00000073670
resolver
ensp
ENSP00000200557
resolver
ensp
ENSP00000443773
resolver
ensp
ENSP00000778022
resolver
enst
ENST00000535346
resolver
genesymbol
ADAM11
resolver
genesymbol_syn
MDC
resolver
hgnc
HGNC:189
resolver
uniprot
B4DKD2
resolver
uniprot
F6WJH5
resolver
uniprot
Q14808
resolver
uniprot
Q14809
resolver
uniprot
Q14810
resolver
uniprot_entry
ADA11_HUMAN
resolver
uniprot_entry
B4DKD2_HUMAN
resolver
uniprot_entry
F6WJH5_HUMAN
resolver
uniprot_sec
Q14808
resolver
uniprot_sec
Q14809
resolver
uniprot_sec
Q14810
resolver
amino_acid_sequence
MRLLRRWAFAALLLSLLPTPGLGTQGPAGALRWGGLPQLGGPGAPEVTEPSRLVRESSGGEVRKQQLDTRVRQEPPGGPPVHLAQVSFVIPAFNSNFTLDLELNHHLLSSQYVERHFSREGTTQHSTGAGDHCYYQGKLRGNPHSFAALSTCQGLHGVFSDGNLTYIVEPQEVAGPWGAPQGPLPHLIYRTPLLPDPLGCREPGCLFAVPAQSAPPNRPRLRRKRQVRRGHPTVHSETKYVELIVINDHQLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQVQDDLLETLARLMVYRREGLPEPSDATHLFSGRTFQSTSSGAAYVGGICSLSHGGGVNEYGNMGAMAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWLGCIMEDTGFYLPRKFSRCSIDEYNQFLQEGGGSCLFNKPLKLLDPPECGNGFVEAGEECDCGSVQECSRAGGNCCKKCTLTHDAMCSDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGRCYGGRCKTRDRQCQVLWGHAAADRFCYEKLNVEGTERGSCGRKGSGWVQCSKQDVLCGFLLCVNISGAPRLGDLVGDISSVTFYHQGKELDCRGGHVQLADGSDLSYVEDGTACGPNMLCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCSIHNPLPTSPPTGETERYKGPSGTNIIIGSIAGAVLVAAIVLGGTGWGFKNIRRGRSGGA
uniprot
proteins
function
FUNCTION: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Required for localization of the potassium channel subunit proteins KCNA1/KV1.1 and KCNA2/KV1.2 at cerebellar cortex basket cell distal terminals, is thereby involved in ephaptic inhibitory synchronization of Purkinje cell firing and response to stress (By similarity). Plays a role in spatial learning and motor coordination (By similarity). Involved in the nociceptive pain response to chemical-derived stimulation (By similarity). {ECO:0000250|UniProtKB:Q9R1V4}.
uniprot
proteins
mass_dalton
83418
uniprot
proteins
post_translational_modification
PTM: The precursor is cleaved by a furin endopeptidase. {ECO:0000250}.
uniprot
proteins
pubmed
14759258
uniprot
proteins
pubmed
18772397
uniprot
proteins
pubmed
7956356
uniprot
proteins
pubmed
8252040
uniprot
proteins
pubmed
9693107
uniprot
proteins
sequence_length
769
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Presynaptic cell membrane {ECO:0000250|UniProtKB:Q9R1V4}; Single-pass type I membrane protein. Perikaryon {ECO:0000250|UniProtKB:Q9R1V4}. Cell projection, axon {ECO:0000250|UniProtKB:Q9R1V4}. Note=Localizes to basket cell terminals and pinceaux. {ECO:0000250|UniProtKB:Q9R1V4}.
uniprot
proteins
transmembrane_region
TRANSMEM 735..755; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins