Aif1
entrez
29427
canonical
uniprot
P55009
canonical
genesymbol
Aif1
resolver
genesymbol_syn
Iba1
resolver
genesymbol_syn
Mrf1
resolver
uniprot
P55007
resolver
uniprot
P70491
resolver
uniprot_entry
AIF1_RAT
resolver
uniprot_sec
P55007
resolver
uniprot_sec
P70491
resolver
amino_acid_sequence
MSQSKDLQGGKAFGLLKAQQEERLDGINKHFLDDPKYSSDEDLQSKLEAFKTKYMEFDLNGNGDIDIMSLKRMLEKLGVPKTHLELKKLIREVSSGSEETFSYSDFLRMMLGKRSAILRMILMYEEKNKEHQKPTGPPAKKAISELP
uniprot
proteins
function
FUNCTION: Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play an role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
16827
uniprot
proteins
pubmed
15060004
uniprot
proteins
pubmed
7769138
uniprot
proteins
pubmed
7783423
uniprot
proteins
pubmed
8713135
uniprot
proteins
pubmed
9698327
uniprot
proteins
sequence_length
147
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O70200}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:O70200}; Peripheral membrane protein {ECO:0000250|UniProtKB:O70200}; Cytoplasmic side {ECO:0000250|UniProtKB:O70200}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:O70200}. Note=Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis. {ECO:0000250|UniProtKB:O70200}.
uniprot
proteins