LY6E
entrez
4061
canonical
uniprot
Q16553
canonical
ensembl
ENSG00000160932
resolver
ensembl
ENSG00000278032
resolver
ensp
ENSP00000292494
resolver
ensp
ENSP00000414307
resolver
ensp
ENSP00000427915
resolver
ensp
ENSP00000428159
resolver
ensp
ENSP00000428169
resolver
ensp
ENSP00000428427
resolver
ensp
ENSP00000428442
resolver
ensp
ENSP00000428572
resolver
ensp
ENSP00000482517
resolver
ensp
ENSP00000487664
resolver
ensp
ENSP00000488421
resolver
ensp
ENSP00000488443
resolver
ensp
ENSP00000488556
resolver
ensp
ENSP00000488559
resolver
ensp
ENSP00000488891
resolver
ensp
ENSP00000561191
resolver
ensp
ENSP00000561192
resolver
ensp
ENSP00000561193
resolver
ensp
ENSP00000561194
resolver
ensp
ENSP00000561195
resolver
ensp
ENSP00000561197
resolver
ensp
ENSP00000561198
resolver
ensp
ENSP00000561199
resolver
ensp
ENSP00000561200
resolver
ensp
ENSP00000561201
resolver
ensp
ENSP00000561202
resolver
ensp
ENSP00000561203
resolver
ensp
ENSP00000561204
resolver
ensp
ENSP00000561205
resolver
ensp
ENSP00000561206
resolver
ensp
ENSP00000561207
resolver
ensp
ENSP00000561209
resolver
ensp
ENSP00000561210
resolver
ensp
ENSP00000561211
resolver
ensp
ENSP00000561212
resolver
ensp
ENSP00000561213
resolver
ensp
ENSP00000561214
resolver
ensp
ENSP00000561215
resolver
ensp
ENSP00000561216
resolver
ensp
ENSP00000561217
resolver
ensp
ENSP00000561218
resolver
ensp
ENSP00000561219
resolver
ensp
ENSP00000561220
resolver
ensp
ENSP00000561221
resolver
ensp
ENSP00000634989
resolver
ensp
ENSP00000634990
resolver
ensp
ENSP00000634991
resolver
enst
ENST00000292494
resolver
enst
ENST00000429120
resolver
enst
ENST00000517503
resolver
enst
ENST00000520466
resolver
enst
ENST00000521003
resolver
enst
ENST00000521699
resolver
enst
ENST00000522024
resolver
enst
ENST00000522971
resolver
enst
ENST00000619718
resolver
enst
ENST00000631568
resolver
enst
ENST00000632424
resolver
enst
ENST00000632516
resolver
enst
ENST00000632519
resolver
enst
ENST00000632812
resolver
enst
ENST00000633451
resolver
enst
ENST00000891132
resolver
enst
ENST00000891133
resolver
enst
ENST00000891134
resolver
enst
ENST00000891135
resolver
enst
ENST00000891136
resolver
enst
ENST00000891138
resolver
enst
ENST00000891139
resolver
enst
ENST00000891140
resolver
enst
ENST00000891141
resolver
enst
ENST00000891142
resolver
enst
ENST00000891143
resolver
enst
ENST00000891144
resolver
enst
ENST00000891145
resolver
enst
ENST00000891146
resolver
enst
ENST00000891147
resolver
enst
ENST00000891148
resolver
enst
ENST00000891150
resolver
enst
ENST00000891151
resolver
enst
ENST00000891152
resolver
enst
ENST00000891153
resolver
enst
ENST00000891154
resolver
enst
ENST00000891155
resolver
enst
ENST00000891156
resolver
enst
ENST00000891157
resolver
enst
ENST00000891158
resolver
enst
ENST00000891159
resolver
enst
ENST00000891160
resolver
enst
ENST00000891161
resolver
enst
ENST00000891162
resolver
enst
ENST00000964930
resolver
enst
ENST00000964931
resolver
enst
ENST00000964932
resolver
genesymbol
LY6E
resolver
genesymbol_syn
9804
resolver
genesymbol_syn
RIGE
resolver
genesymbol_syn
SCA2
resolver
genesymbol_syn
TSA1
resolver
hgnc
HGNC:6727
resolver
uniprot
B2R4X5
resolver
uniprot
D3DWJ2
resolver
uniprot
Q0VDE5
resolver
uniprot_entry
LY6E_HUMAN
resolver
uniprot_sec
B2R4X5
resolver
uniprot_sec
D3DWJ2
resolver
uniprot_sec
Q0VDE5
resolver
amino_acid_sequence
MKIFLPVLLAALLGVERASSLMCFSCLNQKSNLYCLKPTICSDQDNYCVTVSASAGIGNLVTFGHSLSKTCSPACPIPEGVNVGVASMGISCCQSFLCNFSAADGGLRASVTLLGAGLLLSLLPALLRFGP
uniprot
proteins
function
FUNCTION: GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation (By similarity). Restricts the entry of human coronaviruses, including SARS-CoV, MERS-CoV and SARS-CoV-2, by interfering with spike protein-mediated membrane fusion (PubMed:32641482). Also plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity (By similarity). {ECO:0000250|UniProtKB:Q64253, ECO:0000269|PubMed:32641482}.; FUNCTION: (Microbial infection) Promotes entry, likely through an enhanced virus-cell fusion process, of various viruses including HIV-1, West Nile virus, dengue virus and Zika virus (PubMed:28130445). In contrast, the paramyxovirus PIV5, which enters at the plasma membrane, does not require LY6E (PubMed:28130445, PubMed:29610346). Mechanistically, adopts a microtubule-like organization upon viral infection and enhances viral uncoating after endosomal escape (PubMed:28130445, PubMed:30190477). {ECO:0000269|PubMed:28130445, ECO:0000269|PubMed:29610346, ECO:0000269|PubMed:30190477}.
uniprot
proteins
mass_dalton
13507
uniprot
proteins
mutagenesis
MUTAGEN 36; /note="L->A: Complete loss of viral entry enhancement. Abolishes inhibition of human coronaviruses entry."; /evidence="ECO:0000269|PubMed:30190477, ECO:0000269|PubMed:32641482"; MUTAGEN 57; /note="I->A: About 50% loss of viral entry enhancement."; /evidence="ECO:0000269|PubMed:30190477"; MUTAGEN 99; /note="N->A: Abolishes inhibition of human coronaviruses entry."; /evidence="ECO:0000269|PubMed:32641482
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
28130445
uniprot
proteins
pubmed
29610346
uniprot
proteins
pubmed
30190477
uniprot
proteins
pubmed
32641482
uniprot
proteins
pubmed
32704094
uniprot
proteins
pubmed
8650192
uniprot
proteins
pubmed
8757598
uniprot
proteins
pubmed
9551972
uniprot
proteins
sequence_length
131
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q64253}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q64253}.
uniprot
proteins