Lzts1
entrez
211134
canonical
uniprot
P60853
canonical
ensembl
ENSMUSG00000036306
resolver
ensp
ENSMUSP00000039397
resolver
ensp
ENSMUSP00000139117
resolver
enst
ENSMUST00000037049
resolver
enst
ENSMUST00000185176
resolver
genesymbol
Lzts1
resolver
genesymbol_syn
Fez1
resolver
uniprot
B2RTI1
resolver
uniprot_entry
LZTS1_MOUSE
resolver
uniprot_sec
B2RTI1
resolver
amino_acid_sequence
MGSVSSLISGHSFHSKHCRASQYKLRKSSHLKKLNRYSDGLLRFGFSQDSGRGKSSSKMGKSEDFFYIKVSQKARGSHRPDYTALSSGDIGGQTGVDFDPATPPKLMPFSNQLEMSSDKGAVRPTAFKPVLPRSGAILHSSPESTSHQLHPMPPDKPKEQELKPGLCSGALSDSGRNSMSSLPTHSTTSSYQLDPLVTPVGPTSRFGGSAHNITQGIILQDSNMMSLKALSFSDGGSKLAHPGKADKGASCVRSPLSTDECTIQELEQKLLQRETALQKLQRSFDEKEFASGQTFEERPRRTRDELECLEPKSKLKPPSQKSQRTQQVLQLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTNFAPALEETQWEVCQKSGEISLLKQQLKESQLEVNTKASEILSLKAQLKDTRGKLDGMELKTQDLESALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELMELRAQAALHPAPLGPPGVGLTFSEDIPALQRELDRLRAELKEERQGHDQMSSGFQHERLVWKEEKEKVIQYQRQLQQSYLAMYQRNQRLEKALQQLARGDGPGEPFEIDLEGADIPYEDIIATEI
uniprot
proteins
function
FUNCTION: Involved in the regulation of cell growth. May stabilize the active CDC2-cyclin B1 complex and thereby contribute to the regulation of the cell cycle and the prevention of uncontrolled cell proliferation. May act as tumor suppressor (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
67290
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine residues. Hyperphosphorylated by the cAMP-dependent kinase PKA during cell-cycle progression (By similarity). {ECO:0000250}.; PTM: Ubiquitinated by the ECS(ASB7) complex, leading to its degradation. {ECO:0000250|UniProtKB:Q9Y250}.
uniprot
proteins
protein_family
LZTS family
uniprot
proteins
pubmed
10097140
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
599
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Postsynaptic density {ECO:0000250}. Synapse {ECO:0000250}. Note=Associated with the plasma membrane and with microtubules. Detected in dendritic spines, especially in the postsynaptic density (By similarity). {ECO:0000250}.
uniprot
proteins