Slc39a4
entrez
300051
canonical
uniprot
A0JPN2
canonical
ensembl
ENSRNOG00000014314
resolver
ensembl
ENSRNOG00055026065
resolver
ensembl
ENSRNOG00060026757
resolver
ensembl
ENSRNOG00065028737
resolver
ensp
ENSRNOP00000047376
resolver
ensp
ENSRNOP00055036896
resolver
ensp
ENSRNOP00060038553
resolver
ensp
ENSRNOP00065040726
resolver
enst
ENSRNOT00000040422
resolver
enst
ENSRNOT00055044997
resolver
enst
ENSRNOT00060046392
resolver
enst
ENSRNOT00065049604
resolver
genesymbol
Slc39a4
resolver
genesymbol_syn
Zip4
resolver
uniprot
A0A0H2UHY4
resolver
uniprot_entry
A0A0H2UHY4_RAT
resolver
uniprot_entry
S39A4_RAT
resolver
amino_acid_sequence
MMLPKSLTQGLLLAMLVGTAAMVQPYHLLSLLTSGQGALDRTALDGLLNTLVARVHCTDGPCEKCLSVETALALGKPDKPQLAPESVLESRYITYLSAAAALYLNDPEKTCKDIRAGLLASHVDDYLAKLESPEAMTLGLSQLLQKIEAHDASQPTREETCVDVPQLLEEAEEAGVSRSPGLVLTALLDHVLNGSCFQGLPSPQYFVDFVFRQLSSKPRNITLPELEDLMHHLGVGGEDHSDHGDHVDHSHLDREANHQDSELHATHNSSSSVWDTLCLSAKDVMAVYGLSEEAGVSPQAWAQLTPALVQQQLSEACSSSPIIHVQDQLSQAERYLYGSLATLLICLCAVFGLLLLTCAKCSTATHYIMQTFLSLAVGALTGDALLHLIPKVLGLHTHSGEVHSHEEESIGGQSTWRLLAVLGGFYIFFLFESFFNLLLPRDQDHEKDGPCSHGGHSHGISLQLSPSNLRQSKQPHESSRSDLVTEETPELLNPDTRRLRAELRMLPYLITLGDAVHNFADGLAVGAAFSSTWKTGLATSLAVFCHELPHELGDFAALLHAGLTVKRALLLNLASALTAFAGLYVALAVGVGEEGETWILAVATGLFLYVALCDMLPAMMNVRDQRPWLLFLLHNVGLLGGWTILLLLSLYEDSITF
uniprot
proteins
function
FUNCTION: Selective transporter that mediates the uptake of Zn(2+). Plays an essential role for dietary zinc uptake from small intestine (By similarity). The Zn(2+) uniporter activity is regulated by zinc availability. Also exhibits polyspecific binding and transport of Cu(2+), Cd(2+) and possibly Ni(2+) but at higher concentrations (By similarity). {ECO:0000250|UniProtKB:Q6P5W5, ECO:0000250|UniProtKB:Q78IQ7}.
uniprot
proteins
mass_dalton
71253
uniprot
proteins
post_translational_modification
PTM: The extracellular N-terminal ectodomain is cleaved when cells are Zn(2+) deficient, N-terminally cleaved SLC39A4 is internalized at a faster rate. {ECO:0000250|UniProtKB:Q78IQ7}.; PTM: Under excess Zn(2+) conditions, SLC39A4 on the cell surface is rapidly endocytosed, ubiquitinated and degraded. {ECO:0000250|UniProtKB:Q6P5W5}.; PTM: Glycosylated. {ECO:0000250|UniProtKB:Q6P5W5}.
uniprot
proteins
protein_family
ZIP transporter (TC 2.A.5) family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22466565
uniprot
proteins
sequence_length
657
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q78IQ7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A0H3LM39}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q78IQ7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A0H3LM39}. Apical cell membrane {ECO:0000250|UniProtKB:Q78IQ7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A0H3LM39}. Note=Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the plasma membrane in response to zinc availability. Translocates to the apical membrane during zinc deficiency. Expressed on the apical surface of the intestinal wall. {ECO:0000250|UniProtKB:Q78IQ7}.
uniprot
proteins
transmembrane_region
TRANSMEM 336..356; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:A0A0H3LM39"; TRANSMEM 375..395; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:A0A0H3LM39"; TRANSMEM 418..438; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:A0A0H3LM39"; TRANSMEM 509..528; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:A0A0H3LM39"; TRANSMEM 537..563; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:A0A0H3LM39"; TRANSMEM 569..589; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:A0A0H3LM39"; TRANSMEM 598..618; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:A0A0H3LM39"; TRANSMEM 628..648; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:A0A0H3LM39
uniprot
proteins