POLR2M
entrez
81488
canonical
uniprot
P0CAP2
canonical
uniprot
Q6EEV4
canonical
ensembl
ENSG00000255529
resolver
ensp
ENSP00000299638
resolver
ensp
ENSP00000369930
resolver
genesymbol
POLR2M
resolver
genesymbol_syn
GRINL1A
resolver
hgnc
HGNC:14862
resolver
uniprot
Q6EER8
resolver
uniprot
Q6EES2
resolver
uniprot
Q6EEV3
resolver
uniprot
Q6EEV7
resolver
uniprot
Q6EF00
resolver
uniprot
Q6EF01
resolver
uniprot
Q6EF02
resolver
uniprot
Q6EF46
resolver
uniprot
Q6EFN8
resolver
uniprot
Q6EM48
resolver
uniprot
Q6K046
resolver
uniprot
Q6K050
resolver
uniprot
Q6K051
resolver
uniprot
Q6ZQZ3
resolver
uniprot
Q8NC58
resolver
uniprot
Q8NCF3
resolver
uniprot
Q96DI5
resolver
uniprot
Q96JB7
resolver
uniprot
Q96NF5
resolver
uniprot
Q9Y3V6
resolver
uniprot_entry
GL1AD_HUMAN
resolver
uniprot_entry
GRL1A_HUMAN
resolver
uniprot_sec
Q6EER8
resolver
uniprot_sec
Q6EES2
resolver
uniprot_sec
Q6EEV3
resolver
uniprot_sec
Q6EEV7
resolver
uniprot_sec
Q6EF00
resolver
uniprot_sec
Q6EF01
resolver
uniprot_sec
Q6EF02
resolver
uniprot_sec
Q6EF46
resolver
uniprot_sec
Q6EFN8
resolver
uniprot_sec
Q6EM48
resolver
uniprot_sec
Q6K046
resolver
uniprot_sec
Q6K050
resolver
uniprot_sec
Q6K051
resolver
uniprot_sec
Q6ZQZ3
resolver
uniprot_sec
Q8NC58
resolver
uniprot_sec
Q8NCF3
resolver
uniprot_sec
Q96DI5
resolver
uniprot_sec
Q96JB7
resolver
uniprot_sec
Q96NF5
resolver
uniprot_sec
Q9Y3V6
resolver
amino_acid_sequence
MATPARAPESPPSADPALVAGPAEEAECPPPRQPQPAQNVLAAPRLRAPSSRGLGAAEFGGAAGNVEAPGETFAQRVSWGPAESPPGSFSSSSLGAPLPSRTLFPSLEGDFDSVTFASVLRASGRRACCGRAVPLPGQKIHLQIARQR
uniprot
proteins
amino_acid_sequence
MCSLPRGFEPQAPEDLAQRSLVELREMLKRQERLLRNEKFICKLPDKGKKIFDSFAKLKAAIAECEEVRRKSELFNPVSLDCKLRQKAIAEVDVGTDKAQNSDPILDTSSLVPGCSSVDNIKSSQTSQNQGLGRPTLEGDEETSEVEYTVNKGPASSNRDRVPPSSEASEHHPRHRVSSQAEDTSSSFDNLFIDRLQRITIADQGEQQSEENASTKNLTGLSSGTEKKPHYMEVLEMRAKNPVPQLRKFKTNVLPFRQNDSSSHCQKSGSPISSEERRRRDKQHLDDITAARLLPLHHMPTQLLSIEESLALQKQQKQNYEEMQAKLAAQKLAERLNIKMRSYNPEGESSGRYREVRDEDDDWSSDEF
uniprot
proteins
function
FUNCTION: [Isoform 1]: Appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. May play a role in the Mediator complex-dependent regulation of transcription activation. Acts as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II. {ECO:0000269|PubMed:16769904, ECO:0000269|PubMed:30190596}.
uniprot
proteins
mass_dalton
15131
uniprot
proteins
mass_dalton
41740
uniprot
proteins
mutagenesis
MUTAGEN 29..30; /note="KR->DD: Abolishes the interaction with Pol II."; /evidence="ECO:0000269|PubMed:30190596"; MUTAGEN 32; /note="E->K: Stabilizes the interaction with Pol II."; /evidence="ECO:0000269|PubMed:30190596"; MUTAGEN 33; /note="R->D: Markedly reduces the interaction with Pol II."; /evidence="ECO:0000269|PubMed:30190596"; MUTAGEN 49..50; /note="KK->DD: Markedly reduces the interaction with Pol II."; /evidence="ECO:0000269|PubMed:30190596"; MUTAGEN 53; /note="D->K: Stabilizes the interaction with Pol II."; /evidence="ECO:0000269|PubMed:30190596"; MUTAGEN 66..67; /note="EE->KK: Stabilizes the interaction with Pol II."; /evidence="ECO:0000269|PubMed:30190596"; MUTAGEN 303..304; /note="LL->AA: Loss of transcription repressor activity. Abolishes the interaction with Pol II."; /evidence="ECO:0000269|PubMed:30190596
uniprot
proteins
post_translational_modification
PTM: Dephosphorylated at Ser-270 by the PNUTS-PP1 complex, promoting RNA polymerase II transcription pause-release. {ECO:0000269|PubMed:39603240}.
uniprot
proteins
protein_family
GRINL1 family
uniprot
proteins
pubmed
11474202
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15175163
uniprot
proteins
pubmed
15233991
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
16769904
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
30190596
uniprot
proteins
pubmed
39603240
uniprot
proteins
sequence_length
148
uniprot
proteins
sequence_length
368
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000305}.
uniprot
proteins