Sav1
entrez
64010
canonical
uniprot
Q8VEB2
canonical
ensembl
ENSMUSG00000021067
resolver
ensp
ENSMUSP00000021467
resolver
ensp
ENSMUSP00000293225
resolver
ensp
ENSMUSP00000293226
resolver
enst
ENSMUST00000021467
resolver
genesymbol
Sav1
resolver
genesymbol_syn
Ww45
resolver
genesymbol_syn
Wwp3
resolver
uniprot
Q9D9N9
resolver
uniprot
Q9ER46
resolver
uniprot_entry
SAV1_MOUSE
resolver
uniprot_sec
Q9D9N9
resolver
uniprot_sec
Q9ER46
resolver
amino_acid_sequence
MLSRKKTKNEVSKPAEVQGKYVKKETSPLLRNLMPSFIRHGPTIPRRTDLCLPDSSATAFSASGDGVVSRNQSFLRTAIQRTPHEVMRRESHRLSAPSYLVRSLADVPRECGSSQSFLTEVNFAVENGDSGSRYFFSDNFFDGQRRRPLGDRAQEDYRYYEYNHDLFQRMPQSQGRHTSGIGRVTATSLGNLTNHGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKRAQYRHPCAPSVPRYDQPPPITYQPQQTERNQSLLVPANPYHTAEIPDWLQVYARAPVKYDHILKWELFQLADLDTYQGMLKLLFMKELEQIVKLYEAYRQALLTELENRKQRQQWYAQQHGKTFLS
uniprot
proteins
function
FUNCTION: Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation (By similarity). {ECO:0000250, ECO:0000269|PubMed:18369314, ECO:0000269|PubMed:20080689}.
uniprot
proteins
mass_dalton
44845
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by STK3/MST2 and STK4/MST1. Phosphorylation is not required for SAV1 stability and may increase the number of protein binding sites on the scaffold molecule (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
11027580
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18369314
uniprot
proteins
pubmed
20080689
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
386
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
uniprot
proteins