Orc5
entrez
26429
canonical
uniprot
Q9WUV0
canonical
ensembl
ENSMUSG00000029012
resolver
ensp
ENSMUSP00000030872
resolver
enst
ENSMUST00000030872
resolver
genesymbol
Orc5
resolver
genesymbol_syn
Orc5l
resolver
uniprot
Q3TMI6
resolver
uniprot_entry
ORC5_MOUSE
resolver
uniprot_sec
Q3TMI6
resolver
amino_acid_sequence
MSHLESMVLCREAQVSTLQSLFGERHHFSFPSIFIYGHTASGKTYVTQTLLKTLELPHAFVNCVECFTSRLLLEQILNKLSHLNSSDAGCSTEMTCETFNDFVQLFKQVTSAEHLKDQTVYIVLDKAEYLRDMEANLLPGLLRLQELTDRNVTVIFLSEIIWEKFRPNTGCFEPFVLYFPDYSIGNLQKILSHDHPPEYSADFYAAYINILLGVFYTVCRDLKELRHLAVLNFPKYCEPVVKGEAGERDTRKLWRNIEPHLKKAMQTVYLREISSSQWEKLQKDNTDPGQLKGLSAYTHMELPYYSKFILIAAYLASYNPARTDKRFFLKHHGKIKKTNFLKKHEKTSNHLLGPKPFPLDRLLAILYSIVDSRVAPTANIFSQITSLVTLQLLTIVGHEDQLNGPKYKCTVSLDFIRAIARMVNFDIIKYLYDFL
uniprot
proteins
function
FUNCTION: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. {ECO:0000250|UniProtKB:O43913}.
uniprot
proteins
mass_dalton
50217
uniprot
proteins
post_translational_modification
PTM: Multi-mono-ubiquitinated by OBI1; ubiquitination is important for efficient DNA replication origin site activation. Ubiquitination levels are low in mitotic and early G1-phAse cells and are induced in late G1-/early S-phase, peaking in S-phase and decrease toward the end of the cell cycle. {ECO:0000250|UniProtKB:O43913}.
uniprot
proteins
protein_family
ORC5 family
uniprot
proteins
pubmed
10460412
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
435
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O43913}. Chromosome {ECO:0000250|UniProtKB:O43913}.
uniprot
proteins