Cox7a2
entrez
12866
canonical
uniprot
P48771
canonical
ensembl
ENSMUSG00000032330
resolver
ensp
ENSMUSP00000034881
resolver
enst
ENSMUST00000034881
resolver
genesymbol
Cox7a2
resolver
genesymbol_syn
Cox7a3
resolver
genesymbol_syn
Cox7al
resolver
uniprot
O54969
resolver
uniprot
Q545J7
resolver
uniprot_entry
CX7A2_MOUSE
resolver
uniprot_sec
O54969
resolver
uniprot_sec
Q545J7
resolver
amino_acid_sequence
MLRNLLALRQIAQRTISTTSRRHFENKVPEKQKLFQEDNGMPVHLKGGASDALLYRATMALTLGGTAYAIYLLAMAAFPKKQN
uniprot
proteins
function
FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation (PubMed:38575788). The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase (PubMed:38575788). Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water (By similarity). Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)) (By similarity). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix (By similarity). {ECO:0000250|UniProtKB:P10174, ECO:0000269|PubMed:38575788}.
uniprot
proteins
mass_dalton
9291
uniprot
proteins
pathway_participation
PATHWAY: Energy metabolism; oxidative phosphorylation. {ECO:0000269|PubMed:38575788}.
uniprot
proteins
protein_family
Cytochrome c oxidase VIIa family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1659684
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
38575788
uniprot
proteins
sequence_length
83
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:38575788}; Single-pass membrane protein {ECO:0000250|UniProtKB:P14406}.
uniprot
proteins
transmembrane_region
TRANSMEM 49..77; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P07470
uniprot
proteins