DYNLT1
entrez
6993
canonical
uniprot
P63172
canonical
ensembl
ENSG00000146425
resolver
ensp
ENSP00000356056
resolver
ensp
ENSP00000553107
resolver
ensp
ENSP00000662725
resolver
enst
ENST00000367089
resolver
genesymbol
DYNLT1
resolver
genesymbol_syn
TCTEL1
resolver
genesymbol_syn
TCTEX-1
resolver
genesymbol_syn
TCTEX1
resolver
hgnc
HGNC:11697
resolver
uniprot
Q15763
resolver
uniprot
Q5VTU4
resolver
uniprot_entry
DYLT1_HUMAN
resolver
uniprot_sec
Q15763
resolver
uniprot_sec
Q5VTU4
resolver
amino_acid_sequence
MEDYQAAEETAFVVDEVSNIVKEAIESAIGGNAYQHSKVNQWTTNVVEQTLSQLTKLGKPFKYIVTCVIMQKNGAGLHTASSCFWDSSTDGSCTVRWENKTMYCIVSAFGLSI
uniprot
proteins
function
FUNCTION: Component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Required for structural and functional integrity of cilia (By similarity). Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. {ECO:0000250|UniProtKB:A4VEB3}.; FUNCTION: Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation (By similarity). Unrelated to the role in retrograde microtubule-associated movement may play a role in the dimerization of cytoplasmic proteins/domains such as for ACVR2B. Binds to the cytoplasmic domain of ACVR2B and, in vitro, inhibits ACVR2B signaling (PubMed:27502274). {ECO:0000250, ECO:0000269|PubMed:27502274}.; FUNCTION: (Microbial infection) Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. {ECO:0000269|PubMed:18647839}.
uniprot
proteins
mass_dalton
12452
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by BMPR2; the phosphorylation is abolished by BMPR2 mutations in exon 12 which lead to truncated forms of BMPR2 and which are linked to primary pulmonary hypertension (PPH1) [MIM:178600]. The phosphorylation status is proposed to regulate the association with the cytoplasmic dynein complex and may have role in cytoplasmic dynein cargo release (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Dynein light chain Tctex-type family
uniprot
proteins
pubmed
11751937
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14583445
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15194795
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16880273
uniprot
proteins
pubmed
17965411
uniprot
proteins
pubmed
18647839
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21166973
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27502274
uniprot
proteins
pubmed
8646886
uniprot
proteins
sequence_length
113
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Localizes to mitotic spindles. {ECO:0000250}.
uniprot
proteins