TTK
entrez
7272
canonical
uniprot
P33981
canonical
ensembl
ENSG00000112742
resolver
ensp
ENSP00000230510
resolver
ensp
ENSP00000358813
resolver
ensp
ENSP00000422936
resolver
ensp
ENSP00000537671
resolver
genesymbol
TTK
resolver
genesymbol_syn
MPS1
resolver
genesymbol_syn
MPS1L1
resolver
hgnc
HGNC:12401
resolver
uniprot
A8K8U5
resolver
uniprot
B2RDW2
resolver
uniprot
E1P543
resolver
uniprot
Q15272
resolver
uniprot
Q5TCS0
resolver
uniprot
Q9BW51
resolver
uniprot
Q9NTM0
resolver
uniprot_entry
TTK_HUMAN
resolver
uniprot_sec
A8K8U5
resolver
uniprot_sec
B2RDW2
resolver
uniprot_sec
E1P543
resolver
uniprot_sec
Q15272
resolver
uniprot_sec
Q5TCS0
resolver
uniprot_sec
Q9BW51
resolver
uniprot_sec
Q9NTM0
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by the ATP-competitive kinase inhibitor, SP600125.
uniprot
proteins
amino_acid_sequence
MESEDLSGRELTIDSIMNKVRDIKNKFKNEDLTDELSLNKISADTTDNSGTVNQIMMMANNPEDWLSLLLKLEKNSVPLSDALLNKLIGRYSQAIEALPPDKYGQNESFARIQVRFAELKAIQEPDDARDYFQMARANCKKFAFVHISFAQFELSQGNVKKSKQLLQKAVERGAVPLEMLEIALRNLNLQKKQLLSEEEKKNLSASTVLTAQESFSGSLGHLQNRNNSCDSRGQTTKARFLYGENMPPQDAEIGYRNSLRQTNKTKQSCPFGRVPVNLLNSPDCDVKTDDSVVPCFMKRQTSRSECRDLVVPGSKPSGNDSCELRNLKSVQNSHFKEPLVSDEKSSELIITDSITLKNKTESSLLAKLEETKEYQEPEVPESNQKQWQSKRKSECINQNPAASSNHWQIPELARKVNTEQKHTTFEQPVFSVSKQSPPISTSKWFDPKSICKTPSSNTLDDYMSCFRTPVVKNDFPPACQLSTPYGQPACFQQQQHQILATPLQNLQVLASSSANECISVKGRIYSILKQIGSGGSSKVFQVLNEKKQIYAIKYVNLEEADNQTLDSYRNEIAYLNKLQQHSDKIIRLYDYEITDQYIYMVMECGNIDLNSWLKKKKSIDPWERKSYWKNMLEAVHTIHQHGIVHSDLKPANFLIVDGMLKLIDFGIANQMQPDTTSVVKDSQVGTVNYMPPEAIKDMSSSRENGKSKSKISPKSDVWSLGCILYYMTYGKTPFQQIINQISKLHAIIDPNHEIEFPDIPEKDLQDVLKCCLKRDPKQRISIPELLAHPYVQIQTHPVNQMAKGTTEEMKYVLGQLVGLNSPNSILKAAKTLYEHYSGGESHNSSSSKTFEKKRGKK
uniprot
proteins
ec_number
2.7.12.1
uniprot
proteins
function
FUNCTION: Involved in mitotic spindle assembly checkpoint signaling, a process that delays anaphase until chromosomes are bioriented on the spindle, and in the repair of incorrect mitotic kinetochore-spindle microtubule attachments (PubMed:18243099, PubMed:28441529, PubMed:29162720). Phosphorylates MAD1L1 to promote the mitotic spindle assembly checkpoint (PubMed:18243099, PubMed:29162720). Phosphorylates CDCA8/Borealin leading to enhanced AURKB activity at the kinetochore (PubMed:18243099). Phosphorylates SKA3 at 'Ser-34' leading to dissociation of the SKA complex from microtubules and destabilization of microtubule-kinetochore attachments (PubMed:28441529). Phosphorylates KNL1, KNTC1 and autophosphorylates (PubMed:28441529). Phosphorylates MCRS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and promotes chromosome alignment (PubMed:30785839). {ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:28441529, ECO:0000269|PubMed:29162720, ECO:0000269|PubMed:30785839}.
uniprot
proteins
mass_dalton
97072
uniprot
proteins
mutagenesis
MUTAGEN 664; /note="D->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:18243099, ECO:0000269|PubMed:18480048"; MUTAGEN 686; /note="T->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:18480048
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Ser/Thr protein kinase family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1639825
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
18243099
uniprot
proteins
pubmed
18480048
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19120698
uniprot
proteins
pubmed
19273613
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
1956325
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28441529
uniprot
proteins
pubmed
29162720
uniprot
proteins
pubmed
30785839
uniprot
proteins
pubmed
7678926
uniprot
proteins
sequence_length
857
uniprot
proteins