Ces1d
entrez
113902
canonical
uniprot
P16303
canonical
ensembl
ENSRNOG00000015438
resolver
ensp
ENSRNOP00000070536
resolver
enst
ENSRNOT00000090865
resolver
genesymbol
Ces1d
resolver
genesymbol_syn
Ces1f
resolver
genesymbol_syn
Ces3
resolver
uniprot
A0A0G2JY66
resolver
uniprot
Q64574
resolver
uniprot
Q6P785
resolver
uniprot
Q91YG2
resolver
uniprot
Q9QUX7
resolver
uniprot
Q9R135
resolver
uniprot_entry
A0A0G2JY66_RAT
resolver
uniprot_entry
EST1D_RAT
resolver
uniprot_sec
Q64574
resolver
uniprot_sec
Q6P785
resolver
uniprot_sec
Q91YG2
resolver
uniprot_sec
Q9QUX7
resolver
uniprot_sec
Q9R135
resolver
activity_regulation
ACTIVITY REGULATION: FAEE-synthesizing and PNPB-hydrolyzing activities are both inhibited by DFP. {ECO:0000269|PubMed:1429692}.
uniprot
proteins
amino_acid_sequence
MRLYPLVWLFLAACTAWGYPSSPPVVNTVKGKVLGKYVNLEGFAQPVAVFLGIPFAKPPLGSLRFAPPQPAEPWNFVKNTTSYPPMCSQDAVGGQVLSELFTNRKENIPLQFSEDCLYLNVYTPADLTKNSRLPVMVWIHGGGLVVGGASTYDGQVLSAHENVVVVTIQYRLGIWGFFSTGDEHSQGNWGHLDQVAALHWVQDNIANFGGNPGSVTIFGESAGGFSVSALVLSPLAKNLFHRAISESGVVLTSALITTDSKPIANLIATLSGCKTTTSAVMVHCLRQKTEDELLETSLKLNLFKLDLLGNPKESYPFLPTVIDGVVLPKTPEEILAEKSFNTVPYIVGINKQEFGWIIPTLMGYPLSEGKLDQKTAKSLLWKSYPTLKISEKMIPVVAEKYFGGTDDPAKRKDLFQDLVADVMFGVPSVMVSRSHRDAGAPTFMYEFEYRPSFVSAMRPKTVIGDHGDELFSVFGSPFLKDGASEEETNLSKMVMKYWANFARNGNPNGGGLPHWPEYDQKEGYLKIGASTQAAQRLKDKEVAFWSELRAKEAAEEPSHWKHVEL
uniprot
proteins
ec_number
3.1.1.1
uniprot
proteins
ec_number
3.1.1.67
uniprot
proteins
function
FUNCTION: Major lipase in white adipose tissue (By similarity). Involved in the metabolism of xenobiotics and of natural substrates. Hydrolyzes triacylglycerols and monoacylglycerols, with a preference for monoacylglycerols. The susceptibility of the substrate increases with decreasing acyl chain length of the fatty acid moiety. Catalyzes the synthesis of fatty acid ethyl esters (PubMed:1429692). Hydrolyzes retinyl esters (PubMed:12230550). {ECO:0000250|UniProtKB:Q8VCT4, ECO:0000269|PubMed:12230550, ECO:0000269|PubMed:1429692}.
uniprot
proteins
mass_dalton
62147
uniprot
proteins
mutagenesis
MUTAGEN 186; /note="Q->R: No effect on the hydrolysis of PNPC or PNPA, no activity on cholesteryl oleate. No effect on the hydrolysis of PNPC or PNPA, no activity on cholesteryl oleate; when associated with E-492; or with T-491 and E-492. Increases activity on PNPC compared to activity on PNPA; when associated with I-423; T-491 and E-492."; /evidence="ECO:0000269|PubMed:11429416"; MUTAGEN 423; /note="M->I: Increases specific activity against PNPC by 8-fold, does not increase activity against PNPA, no activity on cholesteryl oleate. Increases activity on PNPC compared to activity on PNPA; when associated with R-186; T-491 and E-492. Increases specific activity against PNPC by 7.5-fold and against PNPA by 3.6-fold, and increases cholesteryl esterase activity by 2.7 fold; when associated with S-506."; /evidence="ECO:0000269|PubMed:11429416"; MUTAGEN 491; /note="S->T: No effect on the hydrolysis of PNPC or PNPA, no activity on cholesteryl oleate; when associated with R-186 and E-492. Increases activity on PNPC compared to activity on PNPA; when associated with R-186; I-423 and E-492."; /evidence="ECO:0000269|PubMed:11429416"; MUTAGEN 492; /note="K->E: No effect on the hydrolysis of PNPC or PNPA, no activity on cholesteryl oleate; when associated with R-186; or with R-186 and T-491. Increases activity on PNPC compared to activity on PNPA; when associated with R-186; I-423 and T-491."; /evidence="ECO:0000269|PubMed:11429416"; MUTAGEN 506; /note="N->S: Increases specific activity against PNPC by 6-fold and against PNPA by 8.7-fold, no activity on cholesteryl oleate. Increases specific activity against PNPC by 7.5-fold and against PNPA by 3.6-fold, and increases cholesteryl esterase activity by 2.7 fold; when associated with I-423."; /evidence="ECO:0000269|PubMed:11429416
uniprot
proteins
protein_family
Type-B carboxylesterase/lipase family
uniprot
proteins
pubmed
11429416
uniprot
proteins
pubmed
12230550
uniprot
proteins
pubmed
1429692
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1606962
uniprot
proteins
pubmed
2386485
uniprot
proteins
pubmed
8541339
uniprot
proteins
pubmed
8597091
uniprot
proteins
sequence_length
565
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:Q8VCT4}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8VCT4}. Lipid droplet {ECO:0000250|UniProtKB:Q8VCT4}. Microsome {ECO:0000269|PubMed:12230550}.
uniprot
proteins