TMEM119
entrez
338773
canonical
uniprot
Q4V9L6
canonical
ensembl
ENSG00000183160
resolver
ensp
ENSP00000376553
resolver
ensp
ENSP00000531217
resolver
ensp
ENSP00000531218
resolver
ensp
ENSP00000614543
resolver
ensp
ENSP00000614544
resolver
enst
ENST00000392806
resolver
enst
ENST00000861158
resolver
enst
ENST00000861159
resolver
enst
ENST00000944484
resolver
enst
ENST00000944485
resolver
genesymbol
TMEM119
resolver
hgnc
HGNC:27884
resolver
uniprot
Q6UXE5
resolver
uniprot
Q8N2F5
resolver
uniprot_entry
TM119_HUMAN
resolver
uniprot_sec
Q6UXE5
resolver
uniprot_sec
Q8N2F5
resolver
amino_acid_sequence
MVSAAAPSLLILLLLLLGSVPATDARSVPLKATFLEDVAGSGEAEGSSASSPSLPPPWTPALSPTSMGPQPITLGGPSPPTNFLDGIVDFFRQYVMLIAVVGSLAFLLMFIVCAAVITRQKQKASAYYPSSFPKKKYVDQSDRAGGPRAFSEVPDRAPDSRPEEALDSSRQLQADILAATQNLKSPTRAALGGGDGARMVEGRGAEEEEKGSQEGDQEVQGHGVPVETPEAQEEPCSGVLEGAVVAGEGQGELEGSLLLAQEAQGPVGPPESPCACSSVHPSV
uniprot
proteins
function
FUNCTION: Plays an important role in bone formation and normal bone mineralization. Promotes the differentiation of myoblasts into osteoblasts (PubMed:20025746). May induce the commitment and differentiation of myoblasts into osteoblasts through an enhancement of BMP2 production and interaction with the BMP-RUNX2 pathway. Up-regulates the expression of ATF4, a transcription factor which plays a central role in osteoblast differentiation. Essential for normal spermatogenesis and late testicular differentiation (By similarity). {ECO:0000250|UniProtKB:Q8R138, ECO:0000269|PubMed:20025746}.
uniprot
proteins
mass_dalton
29203
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
20025746
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26250788
uniprot
proteins
pubmed
37453717
uniprot
proteins
sequence_length
283
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20025746, ECO:0000269|PubMed:26250788}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q8R138}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8R138}. Secreted {ECO:0000269|PubMed:37453717}.
uniprot
proteins
transmembrane_region
TRANSMEM 97..117; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins