Slco1a4
entrez
170698
canonical
uniprot
O35913
canonical
ensembl
ENSRNOG00000047493
resolver
ensembl
ENSRNOG00055010096
resolver
ensembl
ENSRNOG00060008044
resolver
ensembl
ENSRNOG00065005585
resolver
ensp
ENSRNOP00000042595
resolver
ensp
ENSRNOP00055013706
resolver
ensp
ENSRNOP00060010135
resolver
ensp
ENSRNOP00065005829
resolver
enst
ENSRNOT00000043374
resolver
enst
ENSRNOT00055017045
resolver
enst
ENSRNOT00060013325
resolver
enst
ENSRNOT00065008301
resolver
genesymbol
Slco1a4
resolver
genesymbol_syn
Oatp1a4
resolver
genesymbol_syn
Oatp2
resolver
genesymbol_syn
Slc21a5
resolver
uniprot
O55224
resolver
uniprot_entry
SO1A4_RAT
resolver
uniprot_sec
O55224
resolver
amino_acid_sequence
MGKSEKRVATHGVRCFAKIKMFLLALTCAYVSKSLSGTYMNSMLTQIERQFGIPTSIVGLINGSFEIGNLLLIIFVSYFGTKLHRPIMIGVGCAVMGLGCFLISLPHFLMGQYEYETILPTSNVSSNSFFCVENRSQTLNPTQDPSECVKEMKSLMWIYVLVGNIIRGIGETPIMPLGISYIEDFAKSENSPLYIGILETGMTIGPLIGLLLASSCANIYVDIESVNTDDLTITPTDTRWVGAWWIGFLVCAGVNILTSFPFFFFPKTLPKEGLQENVDGTENAKEKKHRKKAKEEKRGITKDFFVFMKSLSCNPIYMLFILISVLQFNAFINSFTFMPKYLEQQYGKSTAEVVFLMGLYMLPPICLGYLIGGLIMKKFKVTVKKAAHLAFWLCLSEYLLSFLSYVMTCDNFPVAGLTTSYEGVQHQLYVENKVLADCNTRCNCSTNTWDPVCGDNGLAYMSACLAGCEKSVGTGTNMVFQNCSCIQSSGNSSAVLGLCNKGPDCANKLQYFLIIAIFGCFIYSLAGIPGYMVLLRCIKSEEKSLGVGLHAFCIRILAGIPAPIYFGALIDRTCLHWGTLKCGEPGACRMYDINSFRRLYLGLPAALRGASFVPAFFILRLTRTFQFPGDIESSKTDHAEMKLTLKESECTEVLRSKVTED
uniprot
proteins
function
FUNCTION: Mediates the Na(+)-independent transport of organic anions such as taurocholate, cholate, 17-beta-glucuronosyl estradiol, prostaglandin E2, estrone 3-sulfate, L-thyroxine (T4), the cardiac glycosides ouabain and digoxin and thyroid hormones (PubMed:19129463). May play an especially important role in the brain accumulation and toxicity of digoxin and in the hepatobiliary and renal excretion of cardiac glycosides. Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:19129463). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (PubMed:19129463). {ECO:0000269|PubMed:19129463}.
uniprot
proteins
mass_dalton
73252
uniprot
proteins
protein_family
Organo anion transporter (TC 2.A.60) family
uniprot
proteins
pubmed
19129463
uniprot
proteins
pubmed
9294213
uniprot
proteins
pubmed
9712861
uniprot
proteins
sequence_length
661
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 21..40; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 60..80; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 87..111; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 155..183; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 203..223; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 242..266; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 311..332; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 353..376; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 381..404; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 513..535; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 545..570; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 605..622; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins