Tead1
entrez
21676
canonical
uniprot
P30051
canonical
ensembl
ENSMUSG00000055320
resolver
ensp
ENSMUSP00000060671
resolver
ensp
ENSMUSP00000081755
resolver
ensp
ENSMUSP00000102249
resolver
ensp
ENSMUSP00000127574
resolver
ensp
ENSMUSP00000130459
resolver
ensp
ENSMUSP00000159345
resolver
ensp
ENSMUSP00000159359
resolver
enst
ENSMUST00000069256
resolver
enst
ENSMUST00000106638
resolver
enst
ENSMUST00000164363
resolver
enst
ENSMUST00000239404
resolver
enst
ENSMUST00000239442
resolver
genesymbol
Tead1
resolver
genesymbol_syn
Tcf13
resolver
genesymbol_syn
Tef-1
resolver
genesymbol_syn
Tef1
resolver
uniprot
A0A6I8MX10
resolver
uniprot
A0A6I8MX16
resolver
uniprot
A0ACM8Q3B8
resolver
uniprot
E9Q681
resolver
uniprot
F6TBI7
resolver
uniprot
F6ZIM6
resolver
uniprot
Q3UFP5
resolver
uniprot
Q3USK5
resolver
uniprot
Q6PAQ8
resolver
uniprot
Q80W05
resolver
uniprot_entry
A0A6I8MX10_MOUSE
resolver
uniprot_entry
A0A6I8MX16_MOUSE
resolver
uniprot_entry
A0ACM8Q3B8_MOUSE
resolver
uniprot_entry
F6TBI7_MOUSE
resolver
uniprot_entry
F6ZIM6_MOUSE
resolver
uniprot_entry
Q3UFP5_MOUSE
resolver
uniprot_entry
Q3USK5_MOUSE
resolver
uniprot_entry
Q6PAQ8_MOUSE
resolver
uniprot_entry
Q80W05_MOUSE
resolver
uniprot_entry
TEAD1_MOUSE
resolver
uniprot_sec
E9Q681
resolver
amino_acid_sequence
MEPSSWSGSESPAENMERMSDSADKPIDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSRDFHSKLKDQTAKDKALQHMAAMSSAQIVSATAIHNKLGLPGIPRPTFPGGPGFWPGMIQTGQPGSSQDVKPFVQQAYPIQPAVTAPIPGFEPTSAPAPSVPAWQGRSIGTTKLRLVEFSAFLEQQRDPDSYNKHLFVHIGHANHSYSDPLLESVDIRQIYDKFPEKKGGLKELFGKGPQNAFFLVKFWADLNCNIQDDAGAFYGVSSQYESSENMTVTCSTKVCSFGKQVVEKVETEYARFENGRFVYRINRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILLVVTNRDTQETLLCMACVFEVSNSEHGAQHHIYRLVKD
uniprot
proteins
function
FUNCTION: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
47948
uniprot
proteins
post_translational_modification
PTM: Lactylation by AARS1 promotes nuclear localization and stabilization of YAP1, leading to increased Hippo signaling pathway. Delactylated by SIRT1. {ECO:0000250|UniProtKB:P28347}.
uniprot
proteins
pubmed
7958896
uniprot
proteins
pubmed
8396764
uniprot
proteins
pubmed
8441689
uniprot
proteins
sequence_length
426
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P28347}.
uniprot
proteins