Mphosph10
entrez
67973
canonical
uniprot
Q810V0
canonical
ensembl
ENSMUSG00000030521
resolver
ensp
ENSMUSP00000032735
resolver
enst
ENSMUST00000032735
resolver
genesymbol
Mphosph10
resolver
uniprot
E9QM78
resolver
uniprot
Q9CYN7
resolver
uniprot
Q9D7V6
resolver
uniprot_entry
MPP10_MOUSE
resolver
uniprot_entry
Q9CYN7_MOUSE
resolver
uniprot_entry
Q9D7V6_MOUSE
resolver
uniprot_sec
E9QM78
resolver
amino_acid_sequence
MAPRVFRRQTLERCLREIRKATNRPECFLTIQNGLASNFTSLTKVLYDFNKVLENGRISGSPLQKLEINSFDDEQIWQQLELQNEPVLQYFQNAVSETVEDEDISLLPECEDEECEEDASEVEADNQENLETDLDEEQLSDEGGDVPKGRDRAKSSRKSDPRKSPVFSDEDSDLDFDIGKLEQQTKMQIKPPGKPREKSVVDDKFFKLSEMESFLEKVEKEEEKRPDGEEEDEEDIDLFEDIDSDESEGGLFGRQKIKSNKSSRNLKYKDFFDPVESDEDITGVDEELGPDEEKEEEEGFAEEADESISDTDEDNDLEEDENSDQHKGSLKRVTFALPDDEAEDTSPLAVKQESDEVKSSFEKRQEKMNEKIASLEKELLDKKPWQLQGEVTAQKRPENSLLEETLHFDHAVRMAPVITEETTLHLEDIIKQRIRDQAWDDVERKEKPKEDAYEYKKRLTLDHEKSKLSLAEIYEQEYLKLNQQKTEEEDNPEHVEIQKMMDSLFLKLDALSNFHFIPKPPVPEIKVVSNLPAITMEEVAPVSVSDAALLAPEEIKEKNKAGDLKTAAEKTATDKKRERRKKKYQKRLKIKEKEKRKKLLEKNNPDQSKSSRAAASEKLKQLTKTGKVSLLKDERKDKPLKSSQAFFSKLQDQVKMQINDAKQPEKIKKKKQDISVHKLKL
uniprot
proteins
function
FUNCTION: Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. {ECO:0000250|UniProtKB:O00566}.
uniprot
proteins
mass_dalton
78735
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in M (mitotic) phase. {ECO:0000250|UniProtKB:O00566}.
uniprot
proteins
protein_family
MPP10 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
681
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:O00566}. Chromosome {ECO:0000250|UniProtKB:O00566}. Note=Fibrillar region of the nucleolus. After dissolution of the nucleolus in early M phase becomes associated with chromosomes through metaphase and anaphase. In telophase localized to small cellular prenucleolar bodies that not always contain fibrillarin. The reassociation with nucleolus is preceeded by the arrival of fibrillarin. {ECO:0000250|UniProtKB:O00566}.
uniprot
proteins