Kcnj6
entrez
25743
canonical
uniprot
P48550
canonical
ensembl
ENSRNOG00000001658
resolver
ensp
ENSRNOP00000059308
resolver
ensp
ENSRNOP00000079589
resolver
enst
ENSRNOT00000066940
resolver
enst
ENSRNOT00000119355
resolver
genesymbol
Kcnj6
resolver
genesymbol_syn
GIRK2-2
resolver
genesymbol_syn
GIRK2-3
resolver
genesymbol_syn
GIRK2A-3
resolver
genesymbol_syn
Girk2
resolver
genesymbol_syn
Kcnj7
resolver
uniprot
A0A8I6G5I5
resolver
uniprot
A0A9K3Y8C1
resolver
uniprot
F1LS53
resolver
uniprot
Q54A91
resolver
uniprot
Q8QZW1
resolver
uniprot_entry
A0A8I6G5I5_RAT
resolver
uniprot_entry
A0A9K3Y8C1_RAT
resolver
uniprot_entry
KCNJ6_RAT
resolver
uniprot_entry
Q54A91_RAT
resolver
uniprot_entry
Q8QZW1_RAT
resolver
uniprot_sec
F1LS53
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphatidylinositol 4,5 biphosphate (PtdIns(4,5)P2). {ECO:0000269|PubMed:9486652}.
uniprot
proteins
amino_acid_sequence
MTMAKLTESMTNVLEGDSMDQDVESPVAIHQPKLPKQARDDLPRHISRDRTKRKIQRYVRKDGKCNVHHGNVRETYRYLTDIFTTLVDLKWRFNLLIFVMVYTVTWLFFGMIWWLIAYIRGDMDHIEDPSWTPCVTNLNGFVSAFLFSIETETTIGYGYRVITDKCPEGIILLLIQSVLGSIVNAFMVGCMFVKISQPKKRAETLVFSTHAVISMRDGKLCLMFRVGDLRNSHIVEASIRAKLIKSKQTSEGEFIPLNQTDINVGYYTGDDRLFLVSPLIISHEINQQSPFWEISKAQLPKEELEIVVILEGMVEATGMTCQARSSYVTSEILWGYRFTPVLTLEDGFYEVDYNSFHETHETSTPSLSAKELAELANRAELPLSWSVSSKLNQHAELETEEEEKNPEELTERNGDVANLENESKV
uniprot
proteins
function
FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G protein-coupled receptors. {ECO:0000269|PubMed:7601286, ECO:0000269|PubMed:9486652}.
uniprot
proteins
mass_dalton
48640
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ6 subfamily
uniprot
proteins
pubmed
17828261
uniprot
proteins
pubmed
7601286
uniprot
proteins
pubmed
7626127
uniprot
proteins
pubmed
9486652
uniprot
proteins
sequence_length
425
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 92..116; /note="Helical; Name=M1"; /evidence="ECO:0000250"; TRANSMEM 169..190; /note="Helical; Name=M2"; /evidence="ECO:0000250
uniprot
proteins