ATP8B2
entrez
57198
canonical
uniprot
P98198
canonical
ensembl
ENSG00000143515
resolver
ensp
ENSP00000357472
resolver
ensp
ENSP00000357475
resolver
ensp
ENSP00000500034
resolver
ensp
ENSP00000512728
resolver
ensp
ENSP00000603646
resolver
genesymbol
ATP8B2
resolver
genesymbol_syn
ATPID
resolver
genesymbol_syn
KIAA1137
resolver
hgnc
HGNC:13534
resolver
uniprot
A0A5K1VW70
resolver
uniprot
B4E3P4
resolver
uniprot
Q6NT69
resolver
uniprot
Q7Z486
resolver
uniprot
Q96I43
resolver
uniprot
Q96NQ7
resolver
uniprot_entry
AT8B2_HUMAN
resolver
uniprot_sec
A0A5K1VW70
resolver
uniprot_sec
B4E3P4
resolver
uniprot_sec
Q6NT69
resolver
uniprot_sec
Q7Z486
resolver
uniprot_sec
Q96I43
resolver
uniprot_sec
Q96NQ7
resolver
amino_acid_sequence
MTVPKEMPEKWARAQAPPSWSRKKPSWGTEEERRARANDREYNEKFQYASNCIKTSKYNILTFLPVNLFEQFQEVANTYFLFLLILQLIPQISSLSWFTTIVPLVLVLTITAVKDATDDYFRHKSDNQVNNRQSQVLINGILQQEQWMNVCVGDIIKLENNQFVAADLLLLSSSEPHGLCYIETAELDGETNMKVRQAIPVTSELGDISKLAKFDGEVICEPPNNKLDKFSGTLYWKENKFPLSNQNMLLRGCVLRNTEWCFGLVIFAGPDTKLMQNSGRTKFKRTSIDRLMNTLVLWIFGFLVCMGVILAIGNAIWEHEVGMRFQVYLPWDEAVDSAFFSGFLSFWSYIIILNTVVPISLYVSVEVIRLGHSYFINWDKKMFCMKKRTPAEARTTTLNEELGQVEYIFSDKTGTLTQNIMVFNKCSINGHSYGDVFDVLGHKAELGERPEPVDFSFNPLADKKFLFWDPSLLEAVKIGDPHTHEFFRLLSLCHTVMSEEKNEGELYYKAQSPDEGALVTAARNFGFVFRSRTPKTITVHEMGTAITYQLLAILDFNNIRKRMSVIVRNPEGKIRLYCKGADTILLDRLHHSTQELLNTTMDHLNEYAGEGLRTLVLAYKDLDEEYYEEWAERRLQASLAQDSREDRLASIYEEVENNMMLLGATAIEDKLQQGVPETIALLTLANIKIWVLTGDKQETAVNIGYSCKMLTDDMTEVFIVTGHTVLEVREELRKAREKMMDSSRSVGNGFTYQDKLSSSKLTSVLEAVAGEYALVINGHSLAHALEADMELEFLETACACKAVICCRVTPLQKAQVVELVKKYKKAVTLAIGDGANDVSMIKTAHIGVGISGQEGIQAVLASDYSFSQFKFLQRLLLVHGRWSYLRMCKFLCYFFYKNFAFTMVHFWFGFFCGFSAQTVYDQYFITLYNIVYTSLPVLAMGVFDQDVPEQRSMEYPKLYEPGQLNLLFNKREFFICIAQGIYTSVLMFFIPYGVFADATRDDGTQLADYQSFAVTVATSLVIVVSVQIGLDTGYWTAINHFFIWGSLAVYFAILFAMHSNGLFDMFPNQFRFVGNAQNTLAQPTVWLTIVLTTVVCIMPVVAFRFLRLNLKPDLSDTVRYTQLVRKKQKAQHRCMRRVGRTGSRRSGYAFSHQEGFGELIMSGKNMRLSSLALSSFTTRSSSSWIESLRRKKSDSASSPSGGADKPLKG
uniprot
proteins
ec_number
7.6.2.1
uniprot
proteins
function
FUNCTION: Catalytic component of P4-ATPase flippase complex, which catalyzes the hydrolysis of ATP coupled to the transport of phosphatidylcholine (PC) from the outer to the inner leaflet of the plasma membrane. May contribute to the maintenance of membrane lipid asymmetry. {ECO:0000269|PubMed:25315773}.
uniprot
proteins
mass_dalton
137440
uniprot
proteins
mutagenesis
MUTAGEN 204; /note="E->Q: Impairs ATPase flippase activity."; /evidence="ECO:0000269|PubMed:25315773"; MUTAGEN 411; /note="D->N: Impairs ATPase activity."; /evidence="ECO:0000269|PubMed:20961850
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type IV subfamily
uniprot
proteins
pubmed
10574461
uniprot
proteins
pubmed
12880872
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
20947505
uniprot
proteins
pubmed
20961850
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25315773
uniprot
proteins
sequence_length
1209
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20947505, ECO:0000269|PubMed:20961850, ECO:0000269|PubMed:25315773}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20961850}; Multi-pass membrane protein {ECO:0000255}. Note=Efficient exit from the endoplasmic reticulum requires the presence of CDC50A or CDC50B. {ECO:0000269|PubMed:20961850, ECO:0000269|PubMed:25315773}.
uniprot
proteins
transmembrane_region
TRANSMEM 65..86; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 93..112; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 296..317; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 347..368; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 890..910; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 923..942; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 973..994; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1009..1031; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1038..1058; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1079..1103; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins