Sult2a8
entrez
76971
canonical
uniprot
Q8BGL3
canonical
ensembl
ENSMUSG00000030378
resolver
ensp
ENSMUSP00000066897
resolver
ensp
ENSMUSP00000128428
resolver
ensp
ENSMUSP00000361830
resolver
genesymbol
Sult2a8
resolver
genesymbol_syn
2810007J24Rik
resolver
uniprot
B1PQU4
resolver
uniprot_entry
ST2A8_MOUSE
resolver
uniprot_sec
B1PQU4
resolver
amino_acid_sequence
MTDEFLWIEGIPFPTVYYSQEIIREVRDRFVVRDEDTIIVTYPKSGTHWLNEIVCLILTKGDPTWVQSTIANERTPWIEFENNYRILNSKEGPRLMASLLPIQLFPKSFFSSKAKVIYLIRNPRDVLVSGYHYFNALKQGKEQVPWKIYFENFLQGKSYFGSWFEHACGWISLRKRENILVLSYEQLKKDTRNTIKKICEFLGENLESGELELVLKNISFQIMKERMISQSCLSNIEKHEFIMRKGITGDWKNHFTVAQAEAFDKAFQEKAADFPQELFSWE
uniprot
proteins
ec_number
2.8.2.34
uniprot
proteins
function
FUNCTION: Hepatic sulfotransferase involved in the maintenance of bile acid homeostasis and energy balance. Catalyzes the transfer of sulfonate group from 3'-phosphoadenylyl sulfate (PAPS) to the 7-alpha hydroxy group of primary bile acids to form 7-monosulfate derivatives in the pathway of bile acid elimination. Displays high catalytic efficiency toward cholate, chenodeoxycholate and their glycine and taurine conjugates. {ECO:0000269|PubMed:28442498, ECO:0000269|PubMed:29685090, ECO:0000269|PubMed:33872606}.
uniprot
proteins
mass_dalton
33295
uniprot
proteins
mutagenesis
MUTAGEN 44; /note="K->A: Loss of sulfotransferase activity (at pH 7.5)."; /evidence="ECO:0000269|PubMed:33872606"; MUTAGEN 48; /note="H->N: Decreases sulfotransferase activity (at pH 6.27). Does not affect sulfotransferase activity (at pH 7.5)."; /evidence="ECO:0000269|PubMed:29685090, ECO:0000269|PubMed:33872606"; MUTAGEN 48; /note="H->T: Impairs sulfotransferase activity."; /evidence="ECO:0000269|PubMed:29685090, ECO:0000269|PubMed:33872606"; MUTAGEN 72; /note="N->W: Increases sulfotransferase activity (at pH 7.5)."; /evidence="ECO:0000269|PubMed:33872606"; MUTAGEN 99; /note="L->H: Decreases sulfotransferase activity (at pH 6.27)."; /evidence="ECO:0000269|PubMed:29685090"; MUTAGEN 99; /note="L->T,V: Decreases sulfotransferase activity (at pH 7.5)."; /evidence="ECO:0000269|PubMed:33872606"; MUTAGEN 232; /note="C->S: Decreases sulfotransferase activity (at pH 7.5)."; /evidence="ECO:0000269|PubMed:33872606"; MUTAGEN 236; /note="I->S: Increases sulfotransferase activity."; /evidence="ECO:0000269|PubMed:33872606"; MUTAGEN 237; /note="E->A: Markedly decreases enzyme stability, both apo and ligand-bound forms. Markedly decreases sulfotransferase activity (at pH 7.5)."; /evidence="ECO:0000269|PubMed:33872606"; MUTAGEN 239; /note="H->G: Has little effect on sulfotransferase activity (at pH 7.5)."; /evidence="ECO:0000269|PubMed:33872606
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; bile acid degradation. {ECO:0000269|PubMed:28442498, ECO:0000269|PubMed:29685090, ECO:0000269|PubMed:33872606}.
uniprot
proteins
protein_family
Sulfotransferase 1 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
28442498
uniprot
proteins
pubmed
29685090
uniprot
proteins
pubmed
33872606
uniprot
proteins
sequence_length
282
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:28442498}.
uniprot
proteins