KLRB1
entrez
3820
canonical
uniprot
Q12918
canonical
ensembl
ENSG00000111796
resolver
ensp
ENSP00000229402
resolver
enst
ENST00000229402
resolver
genesymbol
KLRB1
resolver
genesymbol_syn
CLEC5B
resolver
genesymbol_syn
NKRP1A
resolver
hgnc
HGNC:6373
resolver
uniprot
Q24K24
resolver
uniprot_entry
KLRB1_HUMAN
resolver
uniprot_sec
Q24K24
resolver
amino_acid_sequence
MDQQAIYAELNLPTDSGPESSSPSSLPRDVCQGSPWHQFALKLSCAGIILLVLVVTGLSVSVTSLIQKSSIEKCSVDIQQSRNKTTERPGLLNCPIYWQQLREKCLLFSHTVNPWNNSLADCSTKESSLLLIRDKDELIHTQNLIRDKAILFWIGLNFSLSEKNWKWINGSFLNSNDLEIRGDAKENSCISISQTSVYSEYCSTEIRWICQKELTPVRNKVYPDS
uniprot
proteins
function
FUNCTION: Plays an inhibitory role on natural killer (NK) cells cytotoxicity. Activation results in specific acid sphingomyelinase/SMPD1 stimulation with subsequent marked elevation of intracellular ceramide. Activation also leads to AKT1/PKB and RPS6KA1/RSK1 kinases stimulation as well as markedly enhanced T-cell proliferation induced by anti-CD3. Acts as a lectin that binds to the terminal carbohydrate Gal-alpha(1,3)Gal epitope as well as to the N-acetyllactosamine epitope. Also binds to CLEC2D/LLT1 as a ligand and inhibits NK cell-mediated cytotoxicity as well as interferon-gamma secretion in target cells. {ECO:0000269|PubMed:16455998, ECO:0000269|PubMed:16925668, ECO:0000269|PubMed:8077657}.
uniprot
proteins
mass_dalton
25415
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. Contains sialic acid residues. {ECO:0000269|PubMed:8077657}.
uniprot
proteins
pubmed
12100027
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16339512
uniprot
proteins
pubmed
16339513
uniprot
proteins
pubmed
16455998
uniprot
proteins
pubmed
16925668
uniprot
proteins
pubmed
20843815
uniprot
proteins
pubmed
8077657
uniprot
proteins
pubmed
9603467
uniprot
proteins
sequence_length
225
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 46..66; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins