Nptn
entrez
20320
canonical
uniprot
P97300
canonical
ensembl
ENSMUSG00000032336
resolver
ensp
ENSMUSP00000082793
resolver
ensp
ENSMUSP00000135199
resolver
ensp
ENSMUSP00000135541
resolver
ensp
ENSMUSP00000260492
resolver
ensp
ENSMUSP00000260496
resolver
ensp
ENSMUSP00000260515
resolver
ensp
ENSMUSP00000364108
resolver
genesymbol
Nptn
resolver
genesymbol_syn
Sdfr1
resolver
genesymbol_syn
Sdr1
resolver
uniprot
Q3U519
resolver
uniprot
Q8C637
resolver
uniprot
Q8C6H8
resolver
uniprot_entry
NPTN_MOUSE
resolver
uniprot_sec
Q3U519
resolver
uniprot_sec
Q8C637
resolver
uniprot_sec
Q8C6H8
resolver
amino_acid_sequence
MSGSSLPGALALSLLLVSGSLLPGPGAAQNAGFVKSPMSETKLTGDAFELYCDVVGSPTPEIQWWYAEVNRAESFRQLWDGARKRRVTVNTAYGSNGVSVLRITRLTLEDSGTYECRASNDPKRNDLRQNPSITWIRAQATISVLQKPRIVTSEEVIIRESLLPVTLQCNLTSSSHTLMYSYWTRNGVELTATRKNASNMEYRINKPRAEDSGEYHCVYHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDAMMYCKSVGYPHPEWIWRKKENGVFEEISNSSGRFFITNKENYTELSIVNLQITEDPGEYECNATNSIGSASVSTVLRVRSHLAPLWPFLGILAEIIILVVIIVVYEKRKRPDEVPDDDEPAGPMKTNSTNNHKDKNLRQRNTN
uniprot
proteins
function
FUNCTION: Accessory subunit of plasma membrane calcium-transporting ATPase ATP2B2/PMCA2 that stabilizes the transporter at the cell surface (PubMed:40836084). Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity (PubMed:28827723). Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK (By similarity). May also regulate neurite outgrowth by activating the FGFR1 signaling pathway (By similarity). May play a role in synaptic plasticity (By similarity). Promotes localization of XKR8 at the cell membrane (By similarity). {ECO:0000250|UniProtKB:P97546, ECO:0000250|UniProtKB:Q9Y639, ECO:0000269|PubMed:40836084}.
uniprot
proteins
mass_dalton
44373
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250}.
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16944957
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28827723
uniprot
proteins
pubmed
40836084
uniprot
proteins
pubmed
8938438
uniprot
proteins
sequence_length
397
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:40836084}; Single-pass type I membrane protein {ECO:0000269|PubMed:40836084}.; SUBCELLULAR LOCATION: [Isoform 2]: Postsynaptic density {ECO:0000250|UniProtKB:P97546}.
uniprot
proteins
transmembrane_region
TRANSMEM 339..359; /note="Helical"; /evidence="ECO:0000269|PubMed:40836084, ECO:0007744|PDB:9GSD, ECO:0007744|PDB:9GSE, ECO:0007744|PDB:9GSF, ECO:0007744|PDB:9GSG, ECO:0007744|PDB:9GSH, ECO:0007744|PDB:9GTB
uniprot
proteins