FGF2
entrez
2247
canonical
uniprot
P09038
canonical
ensembl
ENSG00000138685
resolver
ensp
ENSP00000264498
resolver
ensp
ENSP00000494222
resolver
genesymbol
FGF2
resolver
genesymbol_syn
FGFB
resolver
hgnc
HGNC:3676
resolver
uniprot
A4LBB8
resolver
uniprot
O00527
resolver
uniprot
P78443
resolver
uniprot
Q16443
resolver
uniprot
Q5PY50
resolver
uniprot
Q7KZ11
resolver
uniprot
Q7KZ72
resolver
uniprot
Q9UC54
resolver
uniprot
Q9UCS5
resolver
uniprot
Q9UCS6
resolver
uniprot_entry
FGF2_HUMAN
resolver
uniprot_sec
A4LBB8
resolver
uniprot_sec
O00527
resolver
uniprot_sec
P78443
resolver
uniprot_sec
Q16443
resolver
uniprot_sec
Q5PY50
resolver
uniprot_sec
Q7KZ11
resolver
uniprot_sec
Q7KZ72
resolver
uniprot_sec
Q9UC54
resolver
uniprot_sec
Q9UCS5
resolver
uniprot_sec
Q9UCS6
resolver
amino_acid_sequence
MVGVGGGDVEDVTPRPGGCQISGRGARGCNGIPGAAAWEAALPRRRPRRHPSVNPRSRAAGSPRTRGRRTEERPSGSRLGDRGRGRALPGGRLGGRGRGRAPERVGGRGRGRGTAAPRAAPAARGSRPGPAGTMAAGSITTLPALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHIKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERLESNNYNTYRSRKYTSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS
uniprot
proteins
function
FUNCTION: Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (PubMed:8663044). Also acts as an integrin ligand which is required for FGF2 signaling (PubMed:28302677). Binds to integrin ITGAV:ITGB3 (PubMed:28302677). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (PubMed:28302677, PubMed:8663044). Functions as a potent mitogen in vitro (PubMed:1721615, PubMed:3732516, PubMed:3964259). Can induce angiogenesis (PubMed:23469107, PubMed:28302677). Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation (PubMed:29501879). {ECO:0000269|PubMed:1721615, ECO:0000269|PubMed:29501879, ECO:0000269|PubMed:3732516, ECO:0000269|PubMed:3964259}.
uniprot
proteins
mass_dalton
30770
uniprot
proteins
mutagenesis
MUTAGEN 181; /note="R->E: No effect on integrin binding."; /evidence="ECO:0000269|PubMed:28302677"; MUTAGEN 186; /note="R->E: No effect on integrin binding."; /evidence="ECO:0000269|PubMed:28302677"; MUTAGEN 188; /note="K->E: No effect on integrin binding."; /evidence="ECO:0000269|PubMed:28302677"; MUTAGEN 261..262; /note="KR->EE: Abolishes binding to integrin ITGAV:ITGB3 and suppresses FGF2 signaling with loss of ERK1/2 activation and reduced ability to induce DNA synthesis, cell migration and angiogenesis. Acts as a potent antagonist of FGF2-mediated angiogenesis."; /evidence="ECO:0000269|PubMed:28302677"; MUTAGEN 267; /note="K->E: Reduces binding to integrin ITGAV:ITGB3 and suppresses FGF2 signaling with reduced ERK1/2 activation and reduced ability to induce DNA synthesis, cell migration and angiogenesis. Acts as a potent antagonist of FGF2-mediated angiogenesis."; /evidence="ECO:0000269|PubMed:28302677
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Tyr-215 regulates FGF2 unconventional secretion. {ECO:0000269|PubMed:20230531}.; PTM: Several N-termini starting at positions 94, 125, 126, 132, 143 and 162 have been identified by direct sequencing.
uniprot
proteins
protein_family
Heparin-binding growth factors family
uniprot
proteins
pubmed
10358027
uniprot
proteins
pubmed
11390973
uniprot
proteins
pubmed
11509569
uniprot
proteins
pubmed
11964394
uniprot
proteins
pubmed
1417798
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
15863030
uniprot
proteins
pubmed
16257968
uniprot
proteins
pubmed
1702556
uniprot
proteins
pubmed
1707542
uniprot
proteins
pubmed
1721615
uniprot
proteins
pubmed
1769963
uniprot
proteins
pubmed
1785797
uniprot
proteins
pubmed
1849658
uniprot
proteins
pubmed
18669637
uniprot
proteins
pubmed
1885605
uniprot
proteins
pubmed
19054851
uniprot
proteins
pubmed
20094046
uniprot
proteins
pubmed
20230531
uniprot
proteins
pubmed
22321063
uniprot
proteins
pubmed
23469107
uniprot
proteins
pubmed
2435284
uniprot
proteins
pubmed
2435575
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
2538817
uniprot
proteins
pubmed
28302677
uniprot
proteins
pubmed
29501879
uniprot
proteins
pubmed
3472745
uniprot
proteins
pubmed
3579930
uniprot
proteins
pubmed
3732516
uniprot
proteins
pubmed
3780670
uniprot
proteins
pubmed
3964259
uniprot
proteins
pubmed
7691311
uniprot
proteins
pubmed
8564983
uniprot
proteins
pubmed
8663044
uniprot
proteins
pubmed
8885834
uniprot
proteins
sequence_length
288
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20230531}. Nucleus {ECO:0000269|PubMed:22321063}. Note=Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane (PubMed:20230531). Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol (PubMed:22321063). Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57 (PubMed:22321063). {ECO:0000269|PubMed:20230531, ECO:0000269|PubMed:22321063}.
uniprot
proteins