TNFAIP8L3
entrez
388121
canonical
uniprot
Q5GJ75
canonical
ensembl
ENSG00000183578
resolver
ensp
ENSP00000328016
resolver
ensp
ENSP00000489743
resolver
enst
ENST00000327536
resolver
enst
ENST00000637513
resolver
genesymbol
TNFAIP8L3
resolver
genesymbol_syn
TIPE3
resolver
hgnc
HGNC:20620
resolver
uniprot
A0A1B0GTK8
resolver
uniprot
Q6ZWD1
resolver
uniprot_entry
A0A1B0GTK8_HUMAN
resolver
uniprot_entry
TP8L3_HUMAN
resolver
uniprot_sec
Q6ZWD1
resolver
amino_acid_sequence
MGKPRQNPSTLVSTLCEAEPKGKLWVNGYAGTQGTRDATLQTRLIPLSFHLQRGKGLAAPLSALSAPRLPERPADGRVAVDAQPAARSMDSDSGEQSEGEPVTAAGPDVFSSKSLALQAQKKILSKIASKTVANMLIDDTSSEIFDELYKVTKEHTHNKKEAHKIMKDLIKVAIKIGILYRNNQFSQEELVIVEKFRKKLNQTAMTIVSFYEVEYTFDRNVLSNLLHECKDLVHELVQRHLTPRTHGRINHVFNHFADVEFLSTLYSLDGDCRPNLKRICEGINKLLDEKVL
uniprot
proteins
function
FUNCTION: Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling. {ECO:0000250|UniProtKB:Q3TBL6}.
uniprot
proteins
mass_dalton
32659
uniprot
proteins
protein_family
TNFAIP8 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
25242044
uniprot
proteins
pubmed
25479791
uniprot
proteins
sequence_length
292
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25479791}. Cell membrane {ECO:0000250|UniProtKB:Q3TBL6}. Note=On PDGF activation, translocates from cytoplasm to plasma membrane. {ECO:0000250|UniProtKB:Q3TBL6}.
uniprot
proteins