PRDX1
entrez
5052
canonical
uniprot
Q06830
canonical
ensembl
ENSG00000117450
resolver
ensp
ENSP00000262746
resolver
ensp
ENSP00000361152
resolver
ensp
ENSP00000389047
resolver
ensp
ENSP00000407034
resolver
ensp
ENSP00000503140
resolver
ensp
ENSP00000579447
resolver
ensp
ENSP00000579448
resolver
ensp
ENSP00000579449
resolver
ensp
ENSP00000579450
resolver
ensp
ENSP00000579451
resolver
ensp
ENSP00000579452
resolver
ensp
ENSP00000579453
resolver
ensp
ENSP00000579454
resolver
ensp
ENSP00000579456
resolver
ensp
ENSP00000584688
resolver
ensp
ENSP00000584689
resolver
ensp
ENSP00000584690
resolver
ensp
ENSP00000584691
resolver
ensp
ENSP00000584692
resolver
ensp
ENSP00000584693
resolver
ensp
ENSP00000584694
resolver
ensp
ENSP00000584695
resolver
ensp
ENSP00000584696
resolver
ensp
ENSP00000584698
resolver
ensp
ENSP00000584699
resolver
ensp
ENSP00000584700
resolver
enst
ENST00000262746
resolver
enst
ENST00000319248
resolver
enst
ENST00000424390
resolver
enst
ENST00000447184
resolver
enst
ENST00000676549
resolver
enst
ENST00000909388
resolver
enst
ENST00000909389
resolver
enst
ENST00000909390
resolver
enst
ENST00000909391
resolver
enst
ENST00000909392
resolver
enst
ENST00000909393
resolver
enst
ENST00000909394
resolver
enst
ENST00000909395
resolver
enst
ENST00000909397
resolver
enst
ENST00000914629
resolver
enst
ENST00000914630
resolver
enst
ENST00000914631
resolver
enst
ENST00000914632
resolver
enst
ENST00000914633
resolver
enst
ENST00000914634
resolver
enst
ENST00000914635
resolver
enst
ENST00000914636
resolver
enst
ENST00000914637
resolver
enst
ENST00000914639
resolver
enst
ENST00000914640
resolver
enst
ENST00000914641
resolver
genesymbol
PRDX1
resolver
genesymbol_syn
PAGA
resolver
genesymbol_syn
PAGB
resolver
genesymbol_syn
TDPX2
resolver
hgnc
HGNC:9352
resolver
uniprot
A0A384NPQ2
resolver
uniprot
B5BU26
resolver
uniprot
D3DPZ8
resolver
uniprot
P35703
resolver
uniprot
Q2V576
resolver
uniprot
Q5T154
resolver
uniprot
Q5T155
resolver
uniprot_entry
A0A384NPQ2_HUMAN
resolver
uniprot_entry
PRDX1_HUMAN
resolver
uniprot_sec
B5BU26
resolver
uniprot_sec
D3DPZ8
resolver
uniprot_sec
P35703
resolver
uniprot_sec
Q2V576
resolver
uniprot_sec
Q5T154
resolver
uniprot_sec
Q5T155
resolver
amino_acid_sequence
MSSGNAKIGHPAPNFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFSDRAEEFKKLNCQVIGASVDSHFCHLAWVNTPKKQGGLGPMNIPLVSDPKRTIAQDYGVLKADEGISFRGLFIIDDKGILRQITVNDLPVGRSVDETLRLVQAFQFTDKHGEVCPAGWKPGSDTIKPDVQKSKEYFSKQK
uniprot
proteins
ec_number
1.11.1.24
uniprot
proteins
function
FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (PubMed:9497357). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). {ECO:0000250|UniProtKB:P0CB50, ECO:0000269|PubMed:9497357}.
uniprot
proteins
mass_dalton
22110
uniprot
proteins
mutagenesis
MUTAGEN 90; /note="T->A: Abolishes phosphorylation by CDK1; 30% reduction in enzymatic activity."; /evidence="ECO:0000269|PubMed:11986303"; MUTAGEN 90; /note="T->D: 87% reduction in enzymatic activity."; /evidence="ECO:0000269|PubMed:11986303"; MUTAGEN 197; /note="K->Q,R: Reduces acetylation."; /evidence="ECO:0000269|PubMed:18606987
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Thr-90 during the M-phase, which leads to a more than 80% decrease in enzymatic activity. {ECO:0000269|PubMed:11986303}.; PTM: Acetylation increases reducing activity and resistance to superoxidation (PubMed:18606987). Deacetylated by HDAC6 which decreases reducing activity (PubMed:18606987). {ECO:0000269|PubMed:18606987}.; PTM: The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) instead of its condensation to a disulfide bond. It can be reactivated by forming a transient disulfide bond with sulfiredoxin SRXN1, which reduces the cysteine sulfinic acid in an ATP- and Mg-dependent manner. {ECO:0000269|PubMed:12059788, ECO:0000269|PubMed:12161445, ECO:0000269|PubMed:12714748, ECO:0000269|PubMed:12853451, ECO:0000269|PubMed:18172504, ECO:0000269|PubMed:19812042}.
uniprot
proteins
protein_family
AhpC/Prx1 subfamily
uniprot
proteins
protein_family
Peroxiredoxin family
uniprot
proteins
pubmed
11986303
uniprot
proteins
pubmed
12059788
uniprot
proteins
pubmed
12161445
uniprot
proteins
pubmed
12714748
uniprot
proteins
pubmed
12853451
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
15105503
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17081065
uniprot
proteins
pubmed
18172504
uniprot
proteins
pubmed
18606987
uniprot
proteins
pubmed
19054851
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19812042
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21969592
uniprot
proteins
pubmed
22905912
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
8026862
uniprot
proteins
pubmed
8496166
uniprot
proteins
pubmed
9497357
uniprot
proteins
sequence_length
199
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17081065, ECO:0000269|PubMed:9497357}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
uniprot
proteins