MOB1A
entrez
55233
canonical
uniprot
Q9H8S9
canonical
ensembl
ENSG00000114978
resolver
ensp
ENSP00000379364
resolver
ensp
ENSP00000552129
resolver
ensp
ENSP00000665234
resolver
genesymbol
MOB1A
resolver
genesymbol_syn
C2orf6
resolver
genesymbol_syn
MOB4B
resolver
genesymbol_syn
MOBK1B
resolver
genesymbol_syn
MOBKL1B
resolver
hgnc
HGNC:16015
resolver
uniprot
Q53S34
resolver
uniprot
Q9H3T5
resolver
uniprot
Q9HAI0
resolver
uniprot
Q9NVE2
resolver
uniprot_entry
MOB1A_HUMAN
resolver
uniprot_sec
Q53S34
resolver
uniprot_sec
Q9H3T5
resolver
uniprot_sec
Q9HAI0
resolver
uniprot_sec
Q9NVE2
resolver
amino_acid_sequence
MSFLFSSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRQAVMLPEGEDLNEWIAVNTVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEYHWADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDSVMQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLGSKDR
uniprot
proteins
function
FUNCTION: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38. {ECO:0000269|PubMed:15197186, ECO:0000269|PubMed:18362890, ECO:0000269|PubMed:19739119}.
uniprot
proteins
mass_dalton
25080
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1. {ECO:0000269|PubMed:15197186, ECO:0000269|PubMed:18328708, ECO:0000269|PubMed:18362890}.
uniprot
proteins
protein_family
MOB1/phocein family
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
12962634
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15197186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18328708
uniprot
proteins
pubmed
18362890
uniprot
proteins
pubmed
19739119
uniprot
proteins
pubmed
22814378
uniprot
proteins
sequence_length
216
uniprot
proteins