HEMK2
entrez
29104
canonical
uniprot
Q9Y5N5
canonical
ensembl
ENSG00000156239
resolver
ensp
ENSP00000286764
resolver
ensp
ENSP00000303584
resolver
genesymbol
HEMK2
resolver
genesymbol_syn
C21orf127
resolver
genesymbol_syn
KMT9
resolver
genesymbol_syn
N6AMT1
resolver
genesymbol_syn
PRED28
resolver
hgnc
HGNC:16021
resolver
uniprot
B2RA97
resolver
uniprot
Q96F73
resolver
uniprot_entry
HEMK2_HUMAN
resolver
uniprot_sec
B2RA97
resolver
uniprot_sec
Q96F73
resolver
amino_acid_sequence
MAGENFATPFHGHVGRGAFSDVYEPAEDTFLLLDALEAAAAELAGVEICLEVGSGSGVVSAFLASMIGPQALYMCTDINPEAAACTLETARCNKVHIQPVITDLVKGLLPRLTEKVDLLVFNPPYVVTPPQEVGSHGIEAAWAGGRNGREVMDRFFPLVPDLLSPRGLFYLVTIKENNPEEILKIMKTKGLQGTTALSRQAGQETLSVLKFTKS
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Methyltransferase that can methylate proteins and, to a lower extent, arsenic (PubMed:18539146, PubMed:21193388, PubMed:30017583, PubMed:31061526, PubMed:31636962). Catalytic subunit of a heterodimer with TRMT112, which monomethylates 'Lys-12' of histone H4 (H4K12me1), a modification present at the promoters of numerous genes encoding cell cycle regulators (PubMed:31061526). Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif (PubMed:18539146, PubMed:31632689, PubMed:31636962). Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated (PubMed:18539146, PubMed:20606008, PubMed:31061526, PubMed:31636962). May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid (PubMed:21193388, PubMed:25997655). It however only plays a limited role in arsenic metabolism compared with AS3MT (PubMed:25997655). {ECO:0000269|PubMed:18539146, ECO:0000269|PubMed:20606008, ECO:0000269|PubMed:21193388, ECO:0000269|PubMed:25997655, ECO:0000269|PubMed:30017583, ECO:0000269|PubMed:31061526, ECO:0000269|PubMed:31632689, ECO:0000269|PubMed:31636962}.
uniprot
proteins
mass_dalton
22957
uniprot
proteins
mutagenesis
MUTAGEN 24; /note="E->K: Reduced protein N(5)-glutamine methyltransferase activity."; /evidence="ECO:0000269|PubMed:31636962"; MUTAGEN 27; /note="E->K: Abolished protein N(5)-glutamine methyltransferase activity."; /evidence="ECO:0000269|PubMed:31636962"; MUTAGEN 28; /note="D->N: Abolished protein N(5)-glutamine methyltransferase activity."; /evidence="ECO:0000269|PubMed:31636962"; MUTAGEN 51; /note="E->A: Abolished protein N(5)-glutamine methyltransferase activity."; /evidence="ECO:0000269|PubMed:31636962"; MUTAGEN 72; /note="L->D: Strongly reduced protein N(5)-glutamine methyltransferase activity."; /evidence="ECO:0000269|PubMed:31636962"; MUTAGEN 77; /note="D->A: Abolished protein N(5)-glutamine methyltransferase activity."; /evidence="ECO:0000269|PubMed:31636962"; MUTAGEN 78; /note="I->A: Abolished protein N(5)-glutamine methyltransferase activity."; /evidence="ECO:0000269|PubMed:31636962"; MUTAGEN 83; /note="A->D: Strongly reduced protein N(5)-glutamine methyltransferase activity."; /evidence="ECO:0000269|PubMed:31636962"; MUTAGEN 103; /note="D->A: Abolished protein N(5)-glutamine methyltransferase activity. Abolished histone-lysine methyltransferase activity."; /evidence="ECO:0000269|PubMed:31061526, ECO:0000269|PubMed:31636962"; MUTAGEN 108; /note="L->D: Strongly reduced protein N(5)-glutamine methyltransferase activity."; /evidence="ECO:0000269|PubMed:31636962"; MUTAGEN 122..125; /note="NPPY->AAAA: Abolished DNA methyltransferase activity."; /evidence="ECO:0000269|PubMed:30017583"; MUTAGEN 122; /note="N->A: Abolished protein N(5)-glutamine methyltransferase activity. Abolished histone-lysine methyltransferase activity."; /evidence="ECO:0000269|PubMed:31061526, ECO:0000269|PubMed:31636962"; MUTAGEN 125; /note="Y->A: Abolished protein N(5)-glutamine methyltransferase activity without affecting histone-lysine methyltransferase activity."; /evidence="ECO:0000269|PubMed:31061526"; MUTAGEN 132; /note="E->K: Abolished protein N(5)-glutamine methyltransferase activity."; /evidence="ECO:0000269|PubMed:31636962"; MUTAGEN 139; /note="E->K: Reduced protein N(5)-glutamine methyltransferase activity."; /evidence="ECO:0000269|PubMed:31636962"; MUTAGEN 154; /note="R->A: Slightly reduced protein N(5)-glutamine methyltransferase activity."; /evidence="ECO:0000269|PubMed:31636962"; MUTAGEN 176; /note="E->K: Abolished protein N(5)-glutamine methyltransferase activity."; /evidence="ECO:0000269|PubMed:31636962"; MUTAGEN 204; /note="E->K: Abolished protein N(5)-glutamine methyltransferase activity."; /evidence="ECO:0000269|PubMed:31636962
uniprot
proteins
post_translational_modification
PTM: [Isoform 1]: Ubiquitinated, leading to its degradation by the proteasome. {ECO:0000269|PubMed:31466382}.; PTM: [Isoform 2]: Ubiquitinated, leading to its degradation by the proteasome. {ECO:0000269|PubMed:31466382}.
uniprot
proteins
protein_family
Eukaryotic/archaeal PrmC-related family
uniprot
proteins
pubmed
10830953
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18539146
uniprot
proteins
pubmed
20606008
uniprot
proteins
pubmed
21193388
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25851604
uniprot
proteins
pubmed
25997655
uniprot
proteins
pubmed
30017583
uniprot
proteins
pubmed
30392959
uniprot
proteins
pubmed
31061526
uniprot
proteins
pubmed
31466382
uniprot
proteins
pubmed
31632689
uniprot
proteins
pubmed
31636962
uniprot
proteins
pubmed
32203414
uniprot
proteins
pubmed
32969463
uniprot
proteins
pubmed
34948388
uniprot
proteins
sequence_length
214
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6SKR2}.
uniprot
proteins