TLE2
entrez
7089
canonical
uniprot
Q04725
canonical
ensembl
ENSG00000065717
resolver
ensp
ENSP00000262953
resolver
ensp
ENSP00000392427
resolver
ensp
ENSP00000466542
resolver
ensp
ENSP00000468279
resolver
ensp
ENSP00000674251
resolver
ensp
ENSP00000674252
resolver
enst
ENST00000590536
resolver
genesymbol
TLE2
resolver
hgnc
HGNC:11838
resolver
uniprot
B4DE03
resolver
uniprot
E9PEV7
resolver
uniprot
F8WCH2
resolver
uniprot
K7EMK7
resolver
uniprot
Q8WVY0
resolver
uniprot
Q9Y6S0
resolver
uniprot_entry
K7EMK7_HUMAN
resolver
uniprot_entry
TLE2_HUMAN
resolver
uniprot_sec
B4DE03
resolver
uniprot_sec
E9PEV7
resolver
uniprot_sec
F8WCH2
resolver
uniprot_sec
Q8WVY0
resolver
uniprot_sec
Q9Y6S0
resolver
amino_acid_sequence
MYPQGRHPTPLQSGQPFKFSILEICDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQVLQAVERAKQVTVGELNSLIGQQLQPLSHHAPPVPLTPRPAGLVGGSATGLLALSGALAAQAQLAAAVKEDRAGVEAEGSRVERAPSRSASPSPPESLVEEERPSGPGGGGKQRADEKEPSGPYESDEDKSDYNLVVDEDQPSEPPSPATTPCGKVPICIPARRDLVDSPASLASSLGSPLPRAKELILNDLPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVALRSPLTLSSPFTTSFSLGSHSTLNGDLSVPSSYVSLHLSPQVSSSVVYGRSPVMAFESHPHLRGSSVSSSLPSIPGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRHARQLHTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVLSLKFASCGRWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISRNNKYIVTGSGDKKATVYEVVY
uniprot
proteins
function
FUNCTION: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
79841
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by XIAP/BIRC4. {ECO:0000269|PubMed:22304967}.
uniprot
proteins
protein_family
WD repeat Groucho/TLE family
uniprot
proteins
pubmed
11266540
uniprot
proteins
pubmed
1303260
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18254933
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
22304967
uniprot
proteins
pubmed
9854018
uniprot
proteins
pubmed
9874198
uniprot
proteins
sequence_length
743
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins