Tob1
entrez
22057
canonical
uniprot
Q61471
canonical
ensembl
ENSMUSG00000037573
resolver
ensp
ENSMUSP00000036039
resolver
ensp
ENSMUSP00000194471
resolver
enst
ENSMUST00000041589
resolver
genesymbol
Tob1
resolver
genesymbol_syn
Tob
resolver
genesymbol_syn
Trob
resolver
uniprot
Q640M3
resolver
uniprot_entry
TOB1_MOUSE
resolver
uniprot_sec
Q640M3
resolver
amino_acid_sequence
MQLEIQVALNFIISYLYNKLPRRRVNIFGEELERLLKKKYEGHWYPEKPYKGSGFRCIHVGEKVDPVIEQASKESGLDIDDVRGNLPQDLSVWIDPFEVSYQIGEKGPVKVLYVDDSSETGCELDKEIKNSFNPEAQVFMPISDPASSVSSSPSPPFGHSAAVSPTFMPRSTQPLTFTTATFAATKFGSTKMKNSGRSSKVARTSPINLGLTVNVNDLLKQKAISSSVHSLYGLGLGSQQQPQPQPQQQQQQQPSSSQPPPPLPQQQQQQPQQQQQQQQQTSALSPNAKEFIFPNMQGQGSSTNGMFPGDSPLNLSPLQYSNAFDVFAAYGGLNEKSFVDGLNFSLNNMQYSNQQFQPVMAN
uniprot
proteins
function
FUNCTION: Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay. {ECO:0000250|UniProtKB:P50616}.
uniprot
proteins
mass_dalton
40056
uniprot
proteins
mutagenesis
MUTAGEN 22..24; /note="RRR->QQQ: Localizes to cytoplasm; when associated with 37-NNN-39."; /evidence="ECO:0000269|PubMed:15235587"; MUTAGEN 37..39; /note="KKK->NNN: Localizes to cytoplasm; when associated with 22-QQQ-24."; /evidence="ECO:0000269|PubMed:15235587"; MUTAGEN 234; /note="L->A: Not exported to the cytoplasm; when associated with A-236."; /evidence="ECO:0000269|PubMed:15235587"; MUTAGEN 236; /note="L->A: Not exported to the cytoplasm; when associated with A-234."; /evidence="ECO:0000269|PubMed:15235587
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser and Thr residues. {ECO:0000250}.
uniprot
proteins
protein_family
BTG family
uniprot
proteins
pubmed
15235587
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
9210596
uniprot
proteins
sequence_length
362
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15235587}. Nucleus {ECO:0000269|PubMed:15235587}. Note=Only a small fraction localizes to the cytoplasm except in late S-phase where more than half of proteins become cytoplasmic.
uniprot
proteins