Slc6a1
entrez
232333
canonical
uniprot
P31648
canonical
ensembl
ENSMUSG00000030310
resolver
ensp
ENSMUSP00000032454
resolver
ensp
ENSMUSP00000145080
resolver
enst
ENSMUST00000032454
resolver
genesymbol
Slc6a1
resolver
genesymbol_syn
Gabt1
resolver
genesymbol_syn
Gat-1
resolver
genesymbol_syn
Gat1
resolver
uniprot
Q6PCX2
resolver
uniprot_entry
Q6PCX2_MOUSE
resolver
uniprot_entry
SC6A1_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by N-[4,4-Diphenyl-3-butenyl]-nipecotic acid (SKF-89976-A), L-2,4-diamino-n-butyric acid, guvacine and nipecotic acid. {ECO:0000269|PubMed:16150932, ECO:0000269|PubMed:8420981}.
uniprot
proteins
amino_acid_sequence
MATDNSKVADGQISTEVSEAPVASDKPKTLVVKVQKKAGDLPDRDTWKGRFDFLMSCVGYAIGLGNVWRFPYLCGKNGGGAFLIPYFLTLIFAGVPLFLLECSLGQYTSIGGLGVWKLAPMFKGVGLAAAVLSFWLNIYYIVIISWAIYYLYNSFTTTLPWKQCDNPWNTDRCFSNYSLVNTTNMTSAVVEFWERNMHQMTDGLDKPGQIRWPLAITLAIAWVLVYFCIWKGVGWTGKVVYFSATYPYIMLIILFFRGVTLPGAKEGILFYITPNFRKLSDSEVWLDAATQIFFSYGLGLGSLIALGSYNSFHNNVYRDSIIVCCINSCTSMFAGFVIFSIVGFMAHVTKRSIADVAASGPGLAFLAYPEAVTQLPISPLWAILFFSMLLMLGIDSQFCTVEGFITALVDEYPRLLRNRRELFIAAVCIVSYLIGLSNITQGGIYVFKLFDYYSASGMSLLFLVFFECVSISWFYGVNRFYDNIQEMVGSRPCIWWKLCWSFFTPIIVAGVFLFSAVQMTPLTMGSYVFPKWGQGVGWLMALSSMVLIPGYMAYMFLTLKGSLKQRLQVMIQPSEDIVRPENGPEQPQAGSSASKEAYI
uniprot
proteins
function
FUNCTION: Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse (PubMed:15234345, PubMed:16150932, PubMed:30270321, PubMed:8420981). The translocation of GABA, however, may also occur in the reverse direction leading to the release of GABA (By similarity). The direction and magnitude of GABA transport is a consequence of the prevailing thermodynamic conditions, determined by membrane potential and the intracellular and extracellular concentrations of Na(+), Cl(-) and GABA (By similarity). Can also mediate sodium- and chloride-dependent transport of hypotaurine but to a much lower extent as compared to GABA (PubMed:30270321). {ECO:0000250|UniProtKB:P23978, ECO:0000269|PubMed:15234345, ECO:0000269|PubMed:16150932, ECO:0000269|PubMed:30270321, ECO:0000269|PubMed:8420981}.
uniprot
proteins
mass_dalton
67001
uniprot
proteins
protein_family
SLC6A1 subfamily
uniprot
proteins
protein_family
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
uniprot
proteins
pubmed
15234345
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16150932
uniprot
proteins
pubmed
1631167
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30270321
uniprot
proteins
pubmed
8420981
uniprot
proteins
sequence_length
599
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P23978}; Multi-pass membrane protein {ECO:0000255}. Presynapse {ECO:0000269|PubMed:15234345}. Note=Localized at the presynaptic terminals of interneurons. {ECO:0000269|PubMed:15234345}.
uniprot
proteins
transmembrane_region
TRANSMEM 53..73; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 81..100; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 124..144; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 212..230; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 239..256; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 292..309; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 321..342; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 375..394; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 422..440; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 457..477; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 498..517; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 536..554; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins