CAMK2A
entrez
815
canonical
uniprot
Q9UQM7
canonical
ensembl
ENSG00000070808
resolver
ensp
ENSP00000261793
resolver
ensp
ENSP00000499939
resolver
ensp
ENSP00000500386
resolver
ensp
ENSP00000500642
resolver
ensp
ENSP00000507199
resolver
enst
ENST00000672752
resolver
genesymbol
CAMK2A
resolver
genesymbol_syn
CAMKA
resolver
genesymbol_syn
KIAA0968
resolver
hgnc
HGNC:1460
resolver
uniprot
A0A5F9ZH21
resolver
uniprot
A8K161
resolver
uniprot
Q7LDD5
resolver
uniprot
Q8IWE0
resolver
uniprot
Q9UL21
resolver
uniprot
Q9Y2H4
resolver
uniprot
Q9Y352
resolver
uniprot_entry
A0A5F9ZH21_HUMAN
resolver
uniprot_entry
A8K161_HUMAN
resolver
uniprot_entry
KCC2A_HUMAN
resolver
uniprot_entry
Q7LDD5_HUMAN
resolver
uniprot_entry
Q8IWE0_HUMAN
resolver
uniprot_sec
Q9UL21
resolver
uniprot_sec
Q9Y2H4
resolver
uniprot_sec
Q9Y352
resolver
activity_regulation
ACTIVITY REGULATION: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-286 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity. {ECO:0000269|PubMed:14722083}.
uniprot
proteins
amino_acid_sequence
MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKSGGNKKSDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
uniprot
proteins
disease_involvement
DISEASE: Intellectual developmental disorder, autosomal dominant 53 (MRD53) [MIM:617798]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269|PubMed:25533962, ECO:0000269|PubMed:28130356, ECO:0000269|PubMed:29100089, ECO:0000269|PubMed:29560374}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Intellectual developmental disorder, autosomal recessive 63 (MRT63) [MIM:618095]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT63 patients manifest global developmental delay, severe intellectual disability, and seizures. {ECO:0000269|PubMed:29784083}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.11.17
uniprot
proteins
function
FUNCTION: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation (PubMed:14722083). Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (By similarity). Regulates dendritic spine development (PubMed:28130356). Also regulates the migration of developing neurons (PubMed:29100089). Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (PubMed:23805378). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (PubMed:35568036). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of PSAT1, inhibiting ferroptosis by promoting GPX4 hydroxylation and stability (PubMed:40281343). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250|UniProtKB:P11275, ECO:0000250|UniProtKB:P11798, ECO:0000269|PubMed:11972023, ECO:0000269|PubMed:23805378, ECO:0000269|PubMed:28130356, ECO:0000269|PubMed:29100089, ECO:0000269|PubMed:40281343}.
uniprot
proteins
mass_dalton
54088
uniprot
proteins
mutagenesis
MUTAGEN 42; /note="K->R: No effect on protein stability or degradation. No effect on neuronal migration; when associated with P-286."; /evidence="ECO:0000269|PubMed:29100089"; MUTAGEN 286; /note="T->A: Abolished autophosphorylation and activation. No effect on neuronal migration."; /evidence="ECO:0000269|PubMed:29100089, ECO:0000269|PubMed:40281343"; MUTAGEN 286; /note="T->D: Mimics phosphorylation; constitutively active. Loss of neuronal migration."; /evidence="ECO:0000269|PubMed:29100089, ECO:0000269|PubMed:40281343"; MUTAGEN 286; /note="T->P: No effect on neuronal migration; when associated with R-42."; /evidence="ECO:0000269|PubMed:29100089"; MUTAGEN 466..478; /note="Missing: Loss of oligomerization."; /evidence="ECO:0000269|PubMed:29784083
uniprot
proteins
post_translational_modification
PTM: Autophosphorylation of Thr-286 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-286 locks the kinase into an activated state. {ECO:0000269|PubMed:14722083}.; PTM: Palmitoylated. Probably palmitoylated by ZDHHC3 and ZDHHC7. {ECO:0000250|UniProtKB:P11275}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
CaMK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10231032
uniprot
proteins
pubmed
11972023
uniprot
proteins
pubmed
14722083
uniprot
proteins
pubmed
15312654
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
23805378
uniprot
proteins
pubmed
25533962
uniprot
proteins
pubmed
28130356
uniprot
proteins
pubmed
29100089
uniprot
proteins
pubmed
29560374
uniprot
proteins
pubmed
29784083
uniprot
proteins
pubmed
35568036
uniprot
proteins
pubmed
39256359
uniprot
proteins
pubmed
40281343
uniprot
proteins
sequence_length
478
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Synapse {ECO:0000250|UniProtKB:P11275}. Postsynaptic density {ECO:0000250|UniProtKB:P11275}. Cell projection, dendritic spine {ECO:0000269|PubMed:28130356}. Cell projection, dendrite {ECO:0000269|PubMed:28130356}. Note=Postsynaptic lipid rafts. {ECO:0000250|UniProtKB:P11275}.
uniprot
proteins