Ifit2
entrez
15958
canonical
uniprot
Q64112
canonical
ensembl
ENSMUSG00000045932
resolver
ensp
ENSMUSP00000099890
resolver
ensp
ENSMUSP00000177453
resolver
ensp
ENSMUSP00000177458
resolver
enst
ENSMUST00000102826
resolver
genesymbol
Ifit2
resolver
genesymbol_syn
Garg39
resolver
genesymbol_syn
Ifi54
resolver
genesymbol_syn
Isg54
resolver
uniprot
F6REG6
resolver
uniprot
Q62385
resolver
uniprot
Q6GTM0
resolver
uniprot_entry
F6REG6_MOUSE
resolver
uniprot_entry
IFIT2_MOUSE
resolver
uniprot_entry
Q6GTM0_MOUSE
resolver
uniprot_sec
Q62385
resolver
amino_acid_sequence
MSTTSKESLVCNLRQLKCHFTWNLIAEDESLDEFEDRVFNKDEFQNSEFKATMCNILAYVKHCRGLNEAALQCLGEAEGFIQQQHPDQVEIRSLVTWGNYAWVYYHMGQFSKAQAYLDKVKQVCKKFSSPYRIENPALDCEEGWARLKCTKNQNERVKVCFQKALEKDPKNPEFTSGWAIAFYRLDDWPARNYCIDSLEQAIQLSPDNTYVKVLLALKLDAVHVHKNQAMALVEEALKKDPSAIDTLLRAARFYCKVYDTDRAIQLLRKALEKLPNNAYVHYYMGCCYRSKVHHMLNRREMVFSGDRKKLEELIQLAVNHLRKAEEIKEMLEYSCSFLADLYIIAKKYDEADYYFQKELSKDLPPGPKQLLHLRYGNFQFFQMKRQDKAIYHYMEGVKIKKKTIPQKKMREKLQRIALRRLHEDESDSEALHILAFLQENGGGQQADKDSERGVDSANQVPSASLDEDGAEY
uniprot
proteins
function
FUNCTION: IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis. {ECO:0000269|PubMed:21085181, ECO:0000269|PubMed:22615570}.
uniprot
proteins
mass_dalton
55021
uniprot
proteins
protein_family
IFIT family
uniprot
proteins
pubmed
16023166
uniprot
proteins
pubmed
20950130
uniprot
proteins
pubmed
21085181
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22615570
uniprot
proteins
pubmed
7896268
uniprot
proteins
pubmed
8660659
uniprot
proteins
sequence_length
472
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
uniprot
proteins