HERPUD1
entrez
9709
canonical
uniprot
Q15011
canonical
ensembl
ENSG00000051108
resolver
ensp
ENSP00000300302
resolver
ensp
ENSP00000369118
resolver
ensp
ENSP00000409555
resolver
ensp
ENSP00000671896
resolver
ensp
ENSP00000768265
resolver
genesymbol
HERPUD1
resolver
genesymbol_syn
HERP
resolver
genesymbol_syn
KIAA0025
resolver
genesymbol_syn
MIF1
resolver
hgnc
HGNC:13744
resolver
uniprot
A4UAE9
resolver
uniprot
E9PGD1
resolver
uniprot
O60644
resolver
uniprot
Q53FP9
resolver
uniprot
Q6IAN8
resolver
uniprot
Q96D92
resolver
uniprot_entry
A4UAE9_HUMAN
resolver
uniprot_entry
HERP1_HUMAN
resolver
uniprot_entry
Q53FP9_HUMAN
resolver
uniprot_sec
E9PGD1
resolver
uniprot_sec
O60644
resolver
uniprot_sec
Q6IAN8
resolver
uniprot_sec
Q96D92
resolver
amino_acid_sequence
MESETEPEPVTLLVKSPNQRHRDLELSGDRGWSVGHLKAHLSRVYPERPRPEDQRLIYSGKLLLDHQCLRDLLPKQEKRHVLHLVCNVKSPSKMPEINAKVAESTEEPAGSNRGQYPEDSSSDGLRQREVLRNLSSPGWENISRPEAAQQAFQGLGPGFSGYTPYGWLQLSWFQQIYARQYYMQYLAATAASGAFVPPPSAQEIPVVSAPAPAPIHNQFPAENQPANQNAAPQVVVNPGANQNLRMNAQGGPIVEEDDEINRDWLDWTYSAATFSVFLSILYFYSSLSRFLMVMGATVVMYLHHVGWFPFRPRPVQNFPNDGPPPDVVNQDPNNNLQEGTDPETEDPNHLPPDRDVLDGEQTSPSFMSTAWLVFKTFFASLLPEGPPAIAN
uniprot
proteins
function
FUNCTION: Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:16289116, PubMed:28827405). Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway (PubMed:18307982). {ECO:0000269|PubMed:16289116, ECO:0000269|PubMed:18307982, ECO:0000269|PubMed:28827405}.
uniprot
proteins
mass_dalton
43720
uniprot
proteins
pubmed
10708769
uniprot
proteins
pubmed
10922362
uniprot
proteins
pubmed
11112790
uniprot
proteins
pubmed
11799129
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
16289116
uniprot
proteins
pubmed
16940180
uniprot
proteins
pubmed
18307982
uniprot
proteins
pubmed
18656546
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28827405
uniprot
proteins
pubmed
7584026
uniprot
proteins
sequence_length
391
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10922362}; Multi-pass membrane protein {ECO:0000269|PubMed:10922362}.
uniprot
proteins
transmembrane_region
TRANSMEM 264..284; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 290..310; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins