ATG14
entrez
22863
canonical
uniprot
Q6ZNE5
canonical
ensembl
ENSG00000126775
resolver
ensp
ENSP00000247178
resolver
genesymbol
ATG14
resolver
genesymbol_syn
ATG14L
resolver
genesymbol_syn
KIAA0831
resolver
hgnc
HGNC:19962
resolver
uniprot
A6NJE4
resolver
uniprot
A8K9U5
resolver
uniprot
B7ZWP5
resolver
uniprot
O94920
resolver
uniprot
Q32MK7
resolver
uniprot
Q32MK8
resolver
uniprot_entry
BAKOR_HUMAN
resolver
uniprot_sec
A6NJE4
resolver
uniprot_sec
A8K9U5
resolver
uniprot_sec
B7ZWP5
resolver
uniprot_sec
O94920
resolver
uniprot_sec
Q32MK7
resolver
uniprot_sec
Q32MK8
resolver
amino_acid_sequence
MASPSGKGARALEAPGCGPRPLARDLVDSVDDAEGLYVAVERCPLCNTTRRRLTCAKCVQSGDFVYFDGRDRERFIDKKERLSRLKSKQEEFQKEVLKAMEGKWITDQLRWKIMSCKMRIEQLKQTICKGNEEMEKNSEGLLKTKEKNQKLYSRAQRHQEKKEKIQRHNRKLGDLVEKKTIDLRSHYERLANLRRSHILELTSVIFPIEEVKTGVRDPADVSSESDSAMTSSTVSKLAEARRTTYLSGRWVCDDHNGDTSISITGPWISLPNNGDYSAYYSWVEEKKTTQGPDMEQSNPAYTISAALCYATQLVNILSHILDVNLPKKLCNSEFCGENLSKQKFTRAVKKLNANILYLCFSQHVNLDQLQPLHTLRNLMYLVSPSSEHLGRSGPFEVRADLEESMEFVDPGVAGESDESGDERVSDEETDLGTDWENLPSPRFCDIPSQSVEVSQSQSTQASPPIASSSAGGMISSAAASVTSWFKAYTGHR
uniprot
proteins
function
FUNCTION: Required for both basal and inducible autophagy. Determines the localization of the autophagy-specific PI3-kinase complex PI3KC3-C1 (PubMed:18843052, PubMed:19050071). Plays a role in autophagosome formation and MAP1LC3/LC3 conjugation to phosphatidylethanolamine (PubMed:19270696, PubMed:20713597). Promotes BECN1 translocation from the trans-Golgi network to autophagosomes (PubMed:20713597). Enhances PIK3C3 activity in a BECN1-dependent manner. Essential for the autophagy-dependent phosphorylation of BECN1 (PubMed:23878393). Stimulates the phosphorylation of BECN1, but suppresses the phosphorylation PIK3C3 by AMPK (PubMed:23878393). Binds to STX17-SNAP29 binary t-SNARE complex on autophagosomes and primes it for VAMP8 interaction to promote autophagosome-endolysosome fusion (PubMed:25686604, PubMed:37632749). Modulates the hepatic lipid metabolism (By similarity). {ECO:0000250|UniProtKB:Q8CDJ3, ECO:0000269|PubMed:18843052, ECO:0000269|PubMed:19050071, ECO:0000269|PubMed:19270696, ECO:0000269|PubMed:20713597, ECO:0000269|PubMed:23878393, ECO:0000269|PubMed:25686604, ECO:0000269|PubMed:37632749}.
uniprot
proteins
mass_dalton
55309
uniprot
proteins
mutagenesis
MUTAGEN 43; /note="C->A: In Atg14L4C4A; fails to localize to the endoplasmic reticulum; when associated with A-46; A-55 and A-58."; /evidence="ECO:0000269|PubMed:20713597, ECO:0000269|PubMed:25686604"; MUTAGEN 46; /note="C->A: In Atg14L4C4A; fails to localize to the endoplasmic reticulum; when associated with A-43; A-55 and A-58."; /evidence="ECO:0000269|PubMed:20713597, ECO:0000269|PubMed:25686604"; MUTAGEN 55; /note="C->A: In Atg14L4C4A; fails to localize to the endoplasmic reticulum; when associated with A-43; A-46 and A-58."; /evidence="ECO:0000269|PubMed:20713597, ECO:0000269|PubMed:25686604"; MUTAGEN 58; /note="C->A: In Atg14L4C4A; fails to localize to the endoplasmic reticulum; when associated with A-43; A-46 and A-55."; /evidence="ECO:0000269|PubMed:20713597, ECO:0000269|PubMed:25686604
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated via 'Lys-6', 'Lys-11' and 'Lys-63'-linked polyubiquitin chains on multiple lysines by MARCHF7, leading to ATG14 aggregation and loss of interaction with STX17. {ECO:0000269|PubMed:37632749}.
uniprot
proteins
protein_family
ATG14 family
uniprot
proteins
pubmed
10048485
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18843052
uniprot
proteins
pubmed
19050071
uniprot
proteins
pubmed
19270696
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
20713597
uniprot
proteins
pubmed
22314358
uniprot
proteins
pubmed
23878393
uniprot
proteins
pubmed
23954414
uniprot
proteins
pubmed
25490155
uniprot
proteins
pubmed
25686604
uniprot
proteins
pubmed
28218432
uniprot
proteins
pubmed
31123703
uniprot
proteins
pubmed
31806350
uniprot
proteins
pubmed
32690950
uniprot
proteins
pubmed
32929276
uniprot
proteins
pubmed
37632749
uniprot
proteins
sequence_length
492
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19050071, ECO:0000269|PubMed:37632749}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19270696, ECO:0000269|PubMed:20713597}; Peripheral membrane protein {ECO:0000305}. Preautophagosomal structure membrane {ECO:0000269|PubMed:18843052, ECO:0000269|PubMed:19050071, ECO:0000269|PubMed:19270696, ECO:0000269|PubMed:22314358}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:19270696, ECO:0000269|PubMed:25686604}; Peripheral membrane protein {ECO:0000305}. Note=Cytosolic under nutrient-rich conditions (PubMed:19050071). Following autophagy stimuli, such as starvation or rapamycin induction, predominantly detected in cytoplasmic foci, identified as isolation membranes and autophagosomes (PubMed:19050071). Accumulates on highly curved PtdIns(3)P enriched autophagic membrane via its BATS domain to sense and maintain membrane curvature (By similarity). Also localizes to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme (By similarity). {ECO:0000250|UniProtKB:Q8CDJ3}.
uniprot
proteins