Slc1a1
entrez
20510
canonical
uniprot
P51906
canonical
ensembl
ENSMUSG00000024935
resolver
ensp
ENSMUSP00000025875
resolver
enst
ENSMUST00000025875
resolver
genesymbol
Slc1a1
resolver
genesymbol_syn
Eaac1
resolver
genesymbol_syn
Eaat3
resolver
uniprot
O35869
resolver
uniprot
O35875
resolver
uniprot
Q6P1F7
resolver
uniprot_entry
EAA3_MOUSE
resolver
uniprot_sec
O35869
resolver
uniprot_sec
O35875
resolver
uniprot_sec
Q6P1F7
resolver
amino_acid_sequence
MGKPTSSGCDWRRFLRNHWLLLSTVAAVVLGIVLGVVVRGHSELSNLDKFYFAFPGEILMRMLKLVILPLIVSSMITGVAALDSNVSGKIGLRAVVYYFSTTVIAVILGIVLVVSIKPGVTQKVNDINRTGKTPEVSTMDAMLDLIRNMFPENLVQACFQQYKTKREEVKPVGDPGGNATEVSVTTAMTTMSENKTKEYKIVGLYSDGINVLGLIIFCLVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYMPIGILFLIAGKIIEVEDWEIFRKLGLYMATVLSGLAIHSLIVLPLLYFIVVRKNPFRFALGMAQALLTALMISSSSATLPVTFRCAEEKNQVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNGLDLSIGQIVTISITATAASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVSSEVNIVNPFALEPTTLDNEDSDTKKSYVNGGFAVDKSDTISFTQTSQF
uniprot
proteins
function
FUNCTION: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:12119102, PubMed:18684713). Can also transport L-cysteine (PubMed:30840898). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion. Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:9233792). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (PubMed:9233792). Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport (PubMed:30840898). Negatively regulated by ARL6IP5 (PubMed:12119102). {ECO:0000250|UniProtKB:P43005, ECO:0000269|PubMed:12119102, ECO:0000269|PubMed:18684713, ECO:0000269|PubMed:30840898, ECO:0000269|PubMed:9233792}.
uniprot
proteins
mass_dalton
56694
uniprot
proteins
protein_family
Dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family
uniprot
proteins
protein_family
SLC1A1 subfamily
uniprot
proteins
pubmed
12119102
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18684713
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26739563
uniprot
proteins
pubmed
30840898
uniprot
proteins
pubmed
7766664
uniprot
proteins
pubmed
9233792
uniprot
proteins
sequence_length
523
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12119102, ECO:0000269|PubMed:18684713, ECO:0000269|PubMed:30840898, ECO:0000269|PubMed:9233792}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P43003}. Apical cell membrane {ECO:0000269|PubMed:26739563}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P43003}. Synapse, synaptosome {ECO:0000269|PubMed:30840898}. Early endosome membrane {ECO:0000269|PubMed:30840898}. Late endosome membrane {ECO:0000269|PubMed:30840898}. Recycling endosome membrane {ECO:0000269|PubMed:30840898}.
uniprot
proteins
transmembrane_region
TRANSMEM 19..38; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 62..82; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 94..114; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 205..228; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 238..265; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 286..307; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 353..379; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 440..461; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P43003
uniprot
proteins