Cyth2
entrez
116692
canonical
uniprot
P63035
canonical
ensembl
ENSRNOG00000021051
resolver
ensembl
ENSRNOG00055006702
resolver
ensembl
ENSRNOG00060010648
resolver
ensembl
ENSRNOG00065031527
resolver
ensp
ENSRNOP00000028588
resolver
ensp
ENSRNOP00055008538
resolver
ensp
ENSRNOP00060014080
resolver
ensp
ENSRNOP00065044759
resolver
enst
ENSRNOT00000028588
resolver
enst
ENSRNOT00055010954
resolver
enst
ENSRNOT00060018075
resolver
enst
ENSRNOT00065054392
resolver
genesymbol
Cyth2
resolver
genesymbol_syn
Pscd2
resolver
genesymbol_syn
Sec7b
resolver
uniprot
O89099
resolver
uniprot
P97695
resolver
uniprot_entry
CYH2_RAT
resolver
uniprot_sec
O89099
resolver
uniprot_sec
P97695
resolver
amino_acid_sequence
MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQRNRKMAMGRKKFNMDPKKGIQFLVEHELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLSVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEDLLRNLYDSIRNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP
uniprot
proteins
function
FUNCTION: Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Promotes the activation of ARF factors through replacement of GDP with GTP. The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (By similarity). Involved in neurite growth (By similarity). {ECO:0000250|UniProtKB:P63034, ECO:0000250|UniProtKB:Q99418}.
uniprot
proteins
mass_dalton
46571
uniprot
proteins
pubmed
11834294
uniprot
proteins
pubmed
11850456
uniprot
proteins
pubmed
9352219
uniprot
proteins
sequence_length
400
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q99418}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q99418}. Cytoplasm {ECO:0000250|UniProtKB:P63034}. Cell projection {ECO:0000250|UniProtKB:P63034}. Cell projection, growth cone {ECO:0000250|UniProtKB:P63034}. Cell junction, tight junction {ECO:0000250|UniProtKB:P63034}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P63034}. Note=Recruited to the cell membrane through its association with ARL4A, ARL4C and ARL4D. Also requires interaction with phosphoinositides for targeting to plasma membrane (By similarity). In differentiating neuroblastoma cells, colocalizes with CCDC120 in both neurite shaft and growth cone areas (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P63034}.
uniprot
proteins