Ildr1
entrez
106347
canonical
uniprot
Q8CBR1
canonical
ensembl
ENSMUSG00000022900
resolver
ensp
ENSMUSP00000023617
resolver
ensp
ENSMUSP00000087045
resolver
ensp
ENSMUSP00000112539
resolver
genesymbol
Ildr1
resolver
uniprot
Q6PFB3
resolver
uniprot
Q8CB39
resolver
uniprot
Q91VS0
resolver
uniprot_entry
ILDR1_MOUSE
resolver
uniprot_sec
Q6PFB3
resolver
uniprot_sec
Q8CB39
resolver
uniprot_sec
Q91VS0
resolver
amino_acid_sequence
MGCGLLAAGLLLFTWLPAGCLSLLVTVQHTERYVTLFASVTLKCDYTTSAQLQDVVVTWRFKSFCKDPIFDYFSASYQAALSLGQDPSNDCSDNQREVRIVAQRRGQSEPVLGVDYRQRKITIQNRADLVINEVMWWDHGVYYCTIEAPGDTSGDPDKEVKLIVLHWLTVIFIILGALLLLLLIGVCWCQCCPQYCCCYIRCPCCPTRCCCPEEALARHRYMKQVQALGPQMMEKPLYWGADRSSQVSSYAMNPLLQRDLSLQSSLPQMPMTQMAAHPPVANGVLEYLEKELRNLNPAQPLPADLRAKSGHPCSMLSSLGSAEVVERRVIHLPPLIRDPPSSRTSNPSHQQRLNAVSSRHCDLSERPRQRHHSDFLRELQDQGMRPWAPGRGELDPHWSGRHHRSRPSESSMPWSDWDSLSECPSSSEAPWPPRRPEPREGAQRRERRRHRSYSPPLPSGPSSWSSEEEKESLPRNWGAQRRHHHRRRRSQSPNWPEEKPPSYRSLDVTPGKNNRKKGNVERRLERESSHSGRSVVI
uniprot
proteins
function
FUNCTION: Maintains epithelial barrier function by recruiting MARVELD2/tricellulin to tricellular tight junctions (tTJs) (PubMed:23239027). Crucial for normal hearing by maintaining the structural and functional integrity of tTJs, which are critical for the survival of auditory neurosensory HCs (PubMed:25217574). Mediates fatty acids and lipoproteins-stimulated CCK/cholecystokinin secretion in the small intestine (PubMed:23863714). In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (PubMed:28785060). {ECO:0000269|PubMed:23239027, ECO:0000269|PubMed:23863714, ECO:0000269|PubMed:25217574, ECO:0000269|PubMed:28785060}.
uniprot
proteins
mass_dalton
61277
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
protein_family
LISCH7 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21255762
uniprot
proteins
pubmed
23239027
uniprot
proteins
pubmed
23863714
uniprot
proteins
pubmed
25217574
uniprot
proteins
pubmed
28785060
uniprot
proteins
sequence_length
537
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23239027, ECO:0000269|PubMed:25217574}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, tight junction {ECO:0000269|PubMed:23239027, ECO:0000269|PubMed:25217574}. Nucleus {ECO:0000269|PubMed:28785060}. Cytoplasm {ECO:0000250|UniProtKB:Q86SU0}. Note=Localizes to tricellular tight junctions (tTJs) between epithelial cells. {ECO:0000269|PubMed:23239027, ECO:0000269|PubMed:25217574}.
uniprot
proteins
transmembrane_region
TRANSMEM 167..187; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins