HEXIM2
entrez
124790
canonical
uniprot
Q96MH2
canonical
ensembl
ENSG00000168517
resolver
ensp
ENSP00000302276
resolver
ensp
ENSP00000464807
resolver
ensp
ENSP00000465086
resolver
ensp
ENSP00000465727
resolver
ensp
ENSP00000466200
resolver
ensp
ENSP00000467517
resolver
ensp
ENSP00000468251
resolver
ensp
ENSP00000468773
resolver
ensp
ENSP00000565048
resolver
ensp
ENSP00000565049
resolver
ensp
ENSP00000565050
resolver
ensp
ENSP00000565051
resolver
ensp
ENSP00000565052
resolver
ensp
ENSP00000565053
resolver
ensp
ENSP00000565054
resolver
ensp
ENSP00000565055
resolver
ensp
ENSP00000565056
resolver
ensp
ENSP00000565057
resolver
ensp
ENSP00000565058
resolver
ensp
ENSP00000565059
resolver
ensp
ENSP00000565060
resolver
ensp
ENSP00000565061
resolver
ensp
ENSP00000565062
resolver
ensp
ENSP00000565063
resolver
ensp
ENSP00000565064
resolver
ensp
ENSP00000565065
resolver
ensp
ENSP00000598758
resolver
ensp
ENSP00000598759
resolver
ensp
ENSP00000633126
resolver
ensp
ENSP00000633127
resolver
ensp
ENSP00000633128
resolver
ensp
ENSP00000633129
resolver
enst
ENST00000307275
resolver
enst
ENST00000585340
resolver
enst
ENST00000586681
resolver
enst
ENST00000589230
resolver
enst
ENST00000591070
resolver
enst
ENST00000591576
resolver
enst
ENST00000592695
resolver
enst
ENST00000593138
resolver
enst
ENST00000894989
resolver
enst
ENST00000894990
resolver
enst
ENST00000894991
resolver
enst
ENST00000894992
resolver
enst
ENST00000894993
resolver
enst
ENST00000894994
resolver
enst
ENST00000894995
resolver
enst
ENST00000894996
resolver
enst
ENST00000894997
resolver
enst
ENST00000894998
resolver
enst
ENST00000894999
resolver
enst
ENST00000895000
resolver
enst
ENST00000895001
resolver
enst
ENST00000895002
resolver
enst
ENST00000895003
resolver
enst
ENST00000895004
resolver
enst
ENST00000895005
resolver
enst
ENST00000895006
resolver
enst
ENST00000928699
resolver
enst
ENST00000928700
resolver
enst
ENST00000963067
resolver
enst
ENST00000963068
resolver
enst
ENST00000963069
resolver
enst
ENST00000963070
resolver
genesymbol
HEXIM2
resolver
hgnc
HGNC:28591
resolver
uniprot
D3DX66
resolver
uniprot_entry
HEXI2_HUMAN
resolver
uniprot_sec
D3DX66
resolver
amino_acid_sequence
MMATPNQTACNAESPVALEEAKTSGAPGSPQTPPERHDSGGSLPLTPRMESHSEDEDLAGAVGGLGWNSRSPRTQSPGGCSAEAVLARKKHRRRPSKRKRHWRPYLELSWAEKQQRDERQSQRASRVREEMFAKGQPVAPYNTTQFLMNDRDPEEPNLDVPHGISHPGSSGESEAGDSDGRGRAHGEFQRKDFSETYERFHTESLQGRSKQELVRDYLELEKRLSQAEEETRRLQQLQACTGQQSCRQVEELAAEVQRLRTENQRLRQENQMWNREGCRCDEEPGT
uniprot
proteins
function
FUNCTION: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:15713661, PubMed:15713662). Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:15713661, PubMed:15713662). {ECO:0000269|PubMed:15713661, ECO:0000269|PubMed:15713662}.
uniprot
proteins
mass_dalton
32419
uniprot
proteins
mutagenesis
MUTAGEN 143; /note="T->A: Loss of interaction with P-TEFb."; /evidence="ECO:0000269|PubMed:15713662"; MUTAGEN 143; /note="T->D: Loss of interaction with P-TEFb."; /evidence="ECO:0000269|PubMed:15713662
uniprot
proteins
protein_family
HEXIM family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15334068
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15713661
uniprot
proteins
pubmed
15713662
uniprot
proteins
pubmed
15994294
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19883659
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
286
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15994294}.
uniprot
proteins