Gfral
entrez
501023
canonical
uniprot
D3ZB94
canonical
ensembl
ENSRNOG00000032063
resolver
ensp
ENSRNOP00000103254
resolver
ensp
ENSRNOP00000104972
resolver
ensp
ENSRNOP00000112426
resolver
genesymbol
Gfral
resolver
uniprot_entry
GFRAL_RAT
resolver
amino_acid_sequence
MLVFIFLAVRLSSENESSSQTNDCAYFMRQCLTDTDGCKQSWRSMEDACLVSGDSCKINNPLPCNLSIQSLVEKHFQFKGCLCTDDLHCTVNKIFGKKCTNKTDSMKKDNKYKRNLTTPLYHDTGFKQMQSCLEVTEACVGDVVCNAQLALYLKACTANGNLCDVKHCQAAIRFFYQNMPFNTAQMLAFCDCAQSDIPCQQSKETLHSKPCALNVVPPPTCLSVIHTCRNDELCRTYYRTFQTECWPHVAGKCREDETCISMLGKQDLTCSGSDSCRAAYLGTFGTVLQVPCACRSITQGEEPLCMAFQHMLHSKSCFNYPTPNVKDISSYERKHSKEITLTGFNSPFSGELIYVVVCMVVTSGILSLVMLKLRIPSKKRDPAPIEIAGAVIIQ
uniprot
proteins
function
FUNCTION: Brainstem-restricted receptor for GDF15 hormone, which triggers an aversive response, characterized by nausea, vomiting, and/or loss of appetite in response to various stresses (PubMed:28846098, PubMed:28846099, PubMed:31928886, PubMed:37060902). The aversive response is both required to reduce continuing exposure to those stresses at the time of exposure and to promote avoidance behavior in the future (By similarity). The GDF15-GFRAL aversive response is triggered by stresses, such as anticancer drugs (camptothecin or cisplatin), cancers or drugs such as metformin (PubMed:37060902). Upon interaction with its ligand, GDF15, mediates the GDF15-induced autophosphorylation and activation of the RET tyrosine kinase receptor, leading to activation of MAPK- and AKT- signaling pathways (By similarity). Ligand-binding activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem (By similarity). The GDF15-GFRAL signal induces expression of genes involved in metabolism, such as lipid metabolism in adipose tissues (By similarity). {ECO:0000250|UniProtKB:Q6SJE0, ECO:0000269|PubMed:28846098, ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:31928886, ECO:0000269|PubMed:37060902}.
uniprot
proteins
mass_dalton
43946
uniprot
proteins
post_translational_modification
PTM: Cleaved and inactivated by MMP14, inhibiting the GDF15-GFRAL aversive response. {ECO:0000250|UniProtKB:Q6UXV0}.
uniprot
proteins
protein_family
GDNFR family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
28846097
uniprot
proteins
pubmed
28846098
uniprot
proteins
pubmed
28846099
uniprot
proteins
pubmed
31928886
uniprot
proteins
pubmed
37060902
uniprot
proteins
sequence_length
394
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:28846098}; Single-pass membrane protein {ECO:0000255}; Extracellular side {ECO:0000305|PubMed:28846098}.
uniprot
proteins
transmembrane_region
TRANSMEM 351..371; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins