RHOJ
entrez
57381
canonical
uniprot
Q9H4E5
canonical
ensembl
ENSG00000126785
resolver
ensp
ENSP00000316729
resolver
ensp
ENSP00000570116
resolver
ensp
ENSP00000787807
resolver
genesymbol
RHOJ
resolver
genesymbol_syn
ARHJ
resolver
genesymbol_syn
RASL7B
resolver
genesymbol_syn
RHOI
resolver
genesymbol_syn
TCL
resolver
hgnc
HGNC:688
resolver
uniprot
Q7Z513
resolver
uniprot
Q96KC1
resolver
uniprot_entry
Q7Z513_HUMAN
resolver
uniprot_entry
RHOJ_HUMAN
resolver
uniprot_sec
Q96KC1
resolver
amino_acid_sequence
MNCKEGTDSSCGCRGNDEKKMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVTVTVGGKQHLLGLYDTAGQEDYNQLRPLSYPNTDVFLICFSVVNPASYHNVQEEWVPELKDCMPHVPYVLIGTQIDLRDDPKTLARLLYMKEKPLTYEHGVKLAKAIGAQCYLECSALTQKGLKAVFDEAILTIFHPKKKKKRCSEGHSCCSII
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Plasma membrane-associated small GTPase specifically involved in angiogenesis (PubMed:21628409, PubMed:24434213, PubMed:30158707). Required for endothelial cell migration during vascular development via its interaction with GLUL (PubMed:30158707). Elicits the formation of F-actin-rich structures, thereby regulating endothelial cell migration (PubMed:30158707). {ECO:0000269|PubMed:21628409, ECO:0000269|PubMed:24434213, ECO:0000269|PubMed:30158707}.
uniprot
proteins
mass_dalton
23821
uniprot
proteins
mutagenesis
MUTAGEN 3; /note="C->A: Impaired localization to the plasma membrane."; /evidence="ECO:0000269|PubMed:30158707"; MUTAGEN 11; /note="C->A: Impaired localization to the plasma membrane."; /evidence="ECO:0000269|PubMed:30158707"; MUTAGEN 17..20; /note="DEKK->AAAA: Impaired localization to the plasma membrane."; /evidence="ECO:0000269|PubMed:27660391"; MUTAGEN 17..18; /note="DE->AA: Does not affect localization to the plasma membrane."; /evidence="ECO:0000269|PubMed:27660391"; MUTAGEN 19..20; /note="KK->AA: Impaired localization to the plasma membrane."; /evidence="ECO:0000269|PubMed:27660391"; MUTAGEN 30; /note="G->V: Causes constitutive activation."; /evidence="ECO:0000269|PubMed:27660391"; MUTAGEN 35; /note="T->N: Dominant negative mutant."; /evidence="ECO:0000269|PubMed:27660391"; MUTAGEN 79; /note="Q->L: Causes constitutive activation."; /evidence="ECO:0000269|PubMed:27660391
uniprot
proteins
post_translational_modification
PTM: Palmitoylated; regulates localization to the plasma membrane and may be mediated by GLUL. {ECO:0000269|PubMed:30158707}.
uniprot
proteins
protein_family
Rho family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10967094
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21628409
uniprot
proteins
pubmed
24434213
uniprot
proteins
pubmed
27660391
uniprot
proteins
pubmed
30158707
uniprot
proteins
sequence_length
214
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27660391, ECO:0000269|PubMed:30158707}; Lipid-anchor {ECO:0000269|PubMed:30158707}; Cytoplasmic side {ECO:0000305}. Note=Localization to the plasma membrane is regulated by GLUL. {ECO:0000269|PubMed:30158707}.
uniprot
proteins