Daam1
entrez
208846
canonical
uniprot
Q8BPM0
canonical
ensembl
ENSMUSG00000034574
resolver
ensp
ENSMUSP00000082406
resolver
ensp
ENSMUSP00000152532
resolver
ensp
ENSMUSP00000152564
resolver
ensp
ENSMUSP00000212754
resolver
ensp
ENSMUSP00000212755
resolver
genesymbol
Daam1
resolver
uniprot
Q3UHB4
resolver
uniprot
Q6DFY0
resolver
uniprot
Q6TAB8
resolver
uniprot
Q80Y68
resolver
uniprot
Q8BTF1
resolver
uniprot
Q9CQQ2
resolver
uniprot_entry
DAAM1_MOUSE
resolver
uniprot_entry
Q8BTF1_MOUSE
resolver
uniprot_sec
Q3UHB4
resolver
uniprot_sec
Q6DFY0
resolver
uniprot_sec
Q6TAB8
resolver
uniprot_sec
Q80Y68
resolver
uniprot_sec
Q9CQQ2
resolver
amino_acid_sequence
MAPRKRGGRGISFIFCCFRNNDHPEITYRLRNDSNFALQTMEPALPMPPVEELDVMFSELVDELDLTDKHREAMFALPAEKKWQIYCSKKKDQEENKGATSWPEFYIDQLNSMAARKSLLALEKEEEEERSKTIESLKTALRTKPMRFVTRFIDLDGLSCILNFLKTMDYETSESRIHTSLIGCIKALMNNSQGRAHVLAHSESINVIAQSLSTENIKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQKYASERTRFQTLINDLDKSTGRYRDEVSLKTAIMSFINAVLSQGAGVESLDFRLHLRYEFLMLGIQPVIDKLREHENSTLDRHLDFFEMLRNEDELEFAKRFELVHIDTKSATQMFELTRRRLTHSEAYPHFMSILHHCLQMPYKRSGNTVQYWLLLDRIIQQIVIQNDKGQDPDSTPLENFNIKNVVRMLVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMKEKLEKETTEHKQVKQQVADLTAQLHELNRRAVCAAVPGGPSPGAPGGPFPSSGLGSLLPPPPPPLLSGGALPPPPPPLPPGGPPPPPGPPPLGGVLPPPGAPVSLTLKKKNIPQPTNALKSFNWSKLPENKLDGTVWTEIDDTKVFKILDLEDLERTFSAYQRQQEFFVNNSKQKEADAIDDTLSSKLKVKELSVIDGRRAQNCNILLSRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDIDLLEEHKHELDRMAKADRFLFEMSRINHYQQRLQSLYFKKKFAERVAEVKPKVEAIRSGSEEVFRSRALKQLLEVVLAFGNYMNKGQRGNAYGFKISSLNKIADTKSSIDKNITLLHYLITIVENKYPKVLNLSEELRDIPQAAKVNMTELDKEISTLRSGLKAVETELEYQKSQPPQPGDKFVSVVSQFITLASFSFSDVEDLLAEAKELFTKAVKHFGEEAGKIQPDEFFGIFDQFLQAVAEAKQENENMRKRKEEEERRARLEAQLKEQRERERKVRKAKESSEESGEFDDLVSALRSGEVFDKDLSKLKRNRKRISNQVTDSSRERPITKLNF
uniprot
proteins
function
FUNCTION: Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments (By similarity). Involved in building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity). Together with DAAM2, required for myocardial maturation and sarcomere assembly (PubMed:26526197). During cell division, may regulate RHOA activation that signals spindle orientation and chromosomal segregation. {ECO:0000250|UniProtKB:B0DOB5, ECO:0000250|UniProtKB:Q9Y4D1, ECO:0000269|PubMed:26526197, ECO:0000269|PubMed:28284839}.
uniprot
proteins
mass_dalton
123370
uniprot
proteins
protein_family
Formin homology family
uniprot
proteins
pubmed
15464228
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15533824
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26526197
uniprot
proteins
pubmed
28284839
uniprot
proteins
pubmed
37189369
uniprot
proteins
sequence_length
1077
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:37189369}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9Y4D1}. Note=Perinuclear. Colocalizes with RHOA and KANK1 around centrosomes. {ECO:0000269|PubMed:28284839, ECO:0000269|PubMed:37189369}.
uniprot
proteins