Bend3
entrez
331623
canonical
uniprot
Q6PAL0
canonical
ensembl
ENSMUSG00000038214
resolver
ensp
ENSMUSP00000127351
resolver
ensp
ENSMUSP00000184345
resolver
enst
ENSMUST00000167488
resolver
genesymbol
Bend3
resolver
genesymbol_syn
Kiaa1553
resolver
uniprot
Q80TC0
resolver
uniprot_entry
BEND3_MOUSE
resolver
uniprot_sec
Q80TC0
resolver
amino_acid_sequence
MNSTEISEDVEEVLKNNPVKAEGSDATLDCSRNSRASEKHLLESVLTALHDSSKRKQLDSDGQPDSVPSVKRRRLIPEALLAGMRTRENSSPCQGNGEPASRGRSGSCAWPAEEEPSTEATVPSYKKPLYGISHKIMEKKNPPSGDLLSPYELFEKANSSSGPSPLRLLSESQKRECGVGVATDGDLNIYFLIQKMFYMLNGLTTNMSQLHSKMDLLSLEVSRVKKQVSPSELVAKFQPPPEYQLTASELKQIAEQSLSCGDLACRLLLQLFPELFSDVDFSRGCSACGFAAKRKLESLHLQLIRNYVEVYYPNVKDTAVWQAECLPQLNDFFSRFWAQREMEDSQPGGQVTNFFEADQVDAGHFLDNKDQEEALSLDRSSTIASDHVVDTQDLTEFLDEASSPGEFAVFLLHRLFPELFDHRKLGEQYSCYGDGGKQELDPQRLQIIRNYTEIYFPDMQEEEAWLQQCAQRINDELEGLGLEGGSEGEAPRDDCYDSSSLPDDISVVKVEDNFEGERPGRRSKKIWLVPIDFDKLEIPQPDFEMPGSDCLLSKEQLRSIYESSLSIGNFASRLLVHLFPELFTHENLRKQYNCSGSLGKKQLDPARIRLIRHYVQLLYPRAKNDRVWTLEFVGKLDERCRRRDTEQRRSYQQQRKVHVPGPECRDLASYAINPERFREEFEGPPLPPERSSKDFCKIPLDELVVPSPDFPVPSPYLLSDKEVREIVQQSLSVGNFAARLLVRLFPELFTTENLRLQYNHSGACNKKQLDPTRLRLIRHYVEAVYPVEKMEEVWHYECIPSIDERCRRPNRKKCDILKKAKKVEK
uniprot
proteins
function
FUNCTION: Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (By similarity). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (PubMed:25457167). Stimulates the ERCC6L translocase and ATPase activities (By similarity). {ECO:0000250|UniProtKB:Q5T5X7, ECO:0000269|PubMed:25457167}.
uniprot
proteins
mass_dalton
94155
uniprot
proteins
post_translational_modification
PTM: Sumoylated at Lys-20 by SUMO1 and at Lys-509 by SUMO1, SUMO2 and SUMO3. Sumoylation probably occurs sequentially, with that of Lys-20 preceding that of Lys-509. It does not alter association with heterochromatin, but is required for the repression of transcription. {ECO:0000250|UniProtKB:Q5T5X7}.
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
25457167
uniprot
proteins
sequence_length
825
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5T5X7}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q5T5X7}. Note=In the nucleus, observed in heterochromatic foci containing CBX1, CBX3, CBX5 and histone H3 trimethylated at 'Lys-9'. Released from chromatin during decondensation. Association with heterochromatin does not depend on sumoylation. {ECO:0000250|UniProtKB:Q5T5X7}.
uniprot
proteins