Tcim
entrez
69068
canonical
uniprot
Q9D915
canonical
ensembl
ENSMUSG00000056313
resolver
ensp
ENSMUSP00000058631
resolver
enst
ENSMUST00000052622
resolver
genesymbol
Tcim
resolver
genesymbol_syn
Tc1
resolver
uniprot_entry
TCIM_MOUSE
resolver
amino_acid_sequence
MKAKPSHQATSMSSSLRVSPSIHGYHFDTAARKKAVGNIFENIDQESLQRLFRNSGDKKAEERAKIIFAIDQDLEEKTRALMALKKRTKDKLLQFLKLRKYSIKVH
uniprot
proteins
function
FUNCTION: Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1. Enhances the proliferation of follicular dendritic cells. Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle. In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity. Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression (By similarity). Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (PubMed:24937306). In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis. However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling (By similarity). {ECO:0000250|UniProtKB:Q9NR00, ECO:0000269|PubMed:24937306}.
uniprot
proteins
mass_dalton
12215
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
24937306
uniprot
proteins
pubmed
25985737
uniprot
proteins
sequence_length
106
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24937306}. Nucleus {ECO:0000269|PubMed:24937306}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9NR00}. Nucleus speckle {ECO:0000250|UniProtKB:Q9NR00}. Note=Localizes in nucleus speckles in presence of CBY1. Translocates to the nucleus upon cellular stress such as H(2)O(2). {ECO:0000250|UniProtKB:Q9NR00}.
uniprot
proteins