Gabrr3
entrez
192258
canonical
uniprot
P50573
canonical
ensembl
ENSRNOG00000001679
resolver
ensp
ENSRNOP00000002281
resolver
enst
ENSRNOT00000002281
resolver
genesymbol
Gabrr3
resolver
uniprot_entry
GBRR3_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by agonists in the following the potency order: muscimol > TACP > TACA > thiomuscimol > CAMP > CACA, when forming a homopentamer (PubMed:11861315). Inhibited by TPMPA, a rho-specific antagonist, when forming a homopentamer (PubMed:11861315). Inhibited antagonists in the following the potency order: TAMP = TPMPA > P4MPA = THIP > 14AA > 3-APA, when forming a homopentamer (PubMed:11861315). {ECO:0000269|PubMed:11861315}.
uniprot
proteins
amino_acid_sequence
MVLAFWLAFFTYTWITLMLDASAVKEPHQQCLSSPKQTRIRETRMRKDDLTKVWPLKREQLLHIEDHDFSTRPGFGGSPVPVGIDVQVESIDSISEVNMDFTMTFYLRHYWKDERLSFPSTTNKSMTFDRRLIQKIWVPDIFFVHSKRSFIHDTTVENIMLRVHPDGNVLFSLRITVSAMCFMDFSRFPLDTQNCSLELESYAYNEEDLMLYWKHGNKSLNTEEHISLSQFFIEEFSASSGLAFYSSTGWYYRLFINFVLRRHIFFFVLQTYFPAMLMVMLSWVSFWIDRRAVPARVSLGITTVLTMSTIVTGVSASMPQVSYVKAVDVYMWVSSLFVFLSVIEYAAVNYLTTVEEWKQLNRRGKISGMYNIDAVQAMAFDGCYHDGETDVDQTSFFLHSEEDSMRTKFTGSPCADSSQIKRKSLGGNVGRIILENNHVIDTYSRIVFPVVYIIFNLFYWGIYV
uniprot
proteins
function
FUNCTION: Rho subunit of the pentameric ligand-gated chloride channels responsible for mediating the effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the brain (PubMed:11861315). Rho-containing GABA-gated chloride channels are a subclass of GABA(A) receptors (GABAARs) entirely composed of rho subunits, where GABA molecules bind at the rho intersubunit interfaces (By similarity). When activated by GABA, rho-GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:11861315). {ECO:0000250|UniProtKB:P24046, ECO:0000269|PubMed:11861315}.
uniprot
proteins
mass_dalton
54031
uniprot
proteins
protein_family
GABRR3 sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
11861315
uniprot
proteins
pubmed
12431995
uniprot
proteins
pubmed
8605242
uniprot
proteins
sequence_length
464
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane; Multi-pass membrane protein {ECO:0000255}. Cell membrane; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 264..284; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 297..317; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 329..349; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 444..464; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins