Tmem30a
entrez
69981
canonical
uniprot
Q8VEK0
canonical
ensembl
ENSMUSG00000032328
resolver
ensp
ENSMUSP00000034878
resolver
enst
ENSMUST00000034878
resolver
genesymbol
Tmem30a
resolver
genesymbol_syn
Cdc50a
resolver
genesymbol_syn
D9Wsu20e
resolver
uniprot
Q3TCJ5
resolver
uniprot
Q3UDH8
resolver
uniprot
Q8R0X6
resolver
uniprot
Q8VEH1
resolver
uniprot_entry
CC50A_MOUSE
resolver
uniprot_sec
Q3TCJ5
resolver
uniprot_sec
Q3UDH8
resolver
uniprot_sec
Q8R0X6
resolver
uniprot_sec
Q8VEH1
resolver
amino_acid_sequence
MAMNYSAKDEVDGGPAGPPGGAAKTRRPDNTAFKQQRLPAWQPILTAGTVLPTFFIIGLIFIPIGIGIFVTSNNIREIEIDYTGTEPSSPCNKCLSPNVTSCACTINFTLKQSFEGNVFMYYGLSNFYQNHRRYVKSRDDSQLNGDPSALLNPSKECEPYRRNEDRPIAPCGAIANSMFNDTLELYLVANESDPKPIPIPLKKKGIAWWTDKNVKFRNPPGKESLEEKFKDTIKPVNWHKAVYELDPEDESNNGFINEDFIVWMRTAALPTFRKLYRLIERRDDLHPTLPAGQYFLNITYNYPVHSFDGRKRMILSTISWMGGKNPFLGIAYITIGSISFLLGVVLLVINHKYRNSSNTADITI
uniprot
proteins
function
FUNCTION: Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:CDC50A flippase complex. ATP8A2:CDC50A may be involved in regulation of neurite outgrowth, and, reconstituted to liposomes, predomiminantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE). The ATP8A1:CDC50A flippase complex seems to play a role in regulation of cell migration probably involving flippase-mediated translocation of phosphatidylethanolamine (PE) at the plasma membrane. Required for the formation of the ATP8A2, ATP8B1 and ATP8B2 P-type ATPAse intermediate phosphoenzymes. Involved in uptake of platelet-activating factor (PAF). Can also mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2, ATP8B4, ATP10A, ATP10B, ATP10D, ATP11A, ATP11B and ATP11C from the ER to other membrane localizations. {ECO:0000269|PubMed:22641037, ECO:0000269|PubMed:23269685, ECO:0000269|PubMed:29799007, ECO:0000269|PubMed:30018401}.
uniprot
proteins
mass_dalton
41061
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. Contains high mannose-type oligosaccharides. {ECO:0000269|PubMed:22253360}.
uniprot
proteins
protein_family
CDC50/LEM3 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22253360
uniprot
proteins
pubmed
22307598
uniprot
proteins
pubmed
22641037
uniprot
proteins
pubmed
23269685
uniprot
proteins
pubmed
24413176
uniprot
proteins
pubmed
29799007
uniprot
proteins
pubmed
30018401
uniprot
proteins
sequence_length
364
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:22253360}; Multi-pass membrane protein {ECO:0000269|PubMed:22253360}. Cell membrane {ECO:0000250}. Golgi apparatus {ECO:0000269|PubMed:22253360}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:22253360}. Apical cell membrane {ECO:0000269|PubMed:22253360}.
uniprot
proteins
transmembrane_region
TRANSMEM 50..70; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 329..349; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins