Cygb
entrez
170520
canonical
uniprot
Q921A4
canonical
ensembl
ENSRNOG00000011541
resolver
ensembl
ENSRNOG00055031221
resolver
ensembl
ENSRNOG00060031403
resolver
ensembl
ENSRNOG00065004770
resolver
ensp
ENSRNOP00000016067
resolver
ensp
ENSRNOP00055044749
resolver
ensp
ENSRNOP00060045078
resolver
ensp
ENSRNOP00065004713
resolver
enst
ENSRNOT00000016067
resolver
enst
ENSRNOT00055054104
resolver
enst
ENSRNOT00060054455
resolver
enst
ENSRNOT00065006894
resolver
genesymbol
Cygb
resolver
genesymbol_syn
Stap
resolver
uniprot_entry
CYGB_RAT
resolver
activity_regulation
ACTIVITY REGULATION: The nitric oxide dioxygenase activity is activated by a reducing system composed of cytochrome b5, its upstream reductase CYB5R3 and NADH. {ECO:0000250|UniProtKB:Q8WWM9}.
uniprot
proteins
amino_acid_sequence
MEKVPGDMEIERRERNEELSEAERKAVQATWARLYANCEDVGVAILVRFFVNFPSAKQYFSQFKHMEDPLEMERSPQLRKHACRVMGALNTVVENLHDPDKVSSVLALVGKAHALKHKVEPMYFKILSGVILDVIAEEFANDFPVETQKAWTKLRGLIYSHVTAAYKEVGWVQQVPNTTTLPATLPSSGP
uniprot
proteins
ec_number
1.11.1.-
uniprot
proteins
ec_number
1.14.12.-
uniprot
proteins
ec_number
1.15.1.1
uniprot
proteins
ec_number
1.7.-.-
uniprot
proteins
function
FUNCTION: Probable multifunctional globin with a hexacoordinated heme iron required for the catalysis of various reactions depending on redox condition of the cell as well as oxygen availability (PubMed:28393874). Has a nitric oxide dioxygenase (NOD) activity and is most probably involved in cell-mediated and oxygen-dependent nitric oxide consumption (PubMed:28393874). By scavenging this second messenger may regulate several biological processes including endothelium-mediated vasodilation and vascular tone (PubMed:28393874). Under normoxic conditions functions as a nitric oxide dioxygenase (NOD) but under hypoxic conditions the globin may switch its function to that of a nitrite (NO2) reductase (NiR), generating nitric oxide. Could also have peroxidase and superoxide dismutase activities, detoxifying reactive oxygen species and protecting cells against oxidative stress. Also binds dioxygen with low affinity and could function as an oxygen sensor but has probably no function as a respiratory oxygen carrier (By similarity). {ECO:0000250|UniProtKB:Q8WWM9, ECO:0000269|PubMed:28393874}.
uniprot
proteins
mass_dalton
21497
uniprot
proteins
post_translational_modification
PTM: The formation of an intramolecular disulfide bond between cysteines Cys-38 and Cys-83 specifically enhances the nitrite reductase activity. {ECO:0000250|UniProtKB:Q8WWM9}.
uniprot
proteins
protein_family
Globin family
uniprot
proteins
pubmed
11320098
uniprot
proteins
pubmed
14647402
uniprot
proteins
pubmed
14660570
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
28393874
uniprot
proteins
sequence_length
190
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14647402}. Nucleus {ECO:0000250|UniProtKB:Q8WWM9}.
uniprot
proteins