FBXW12
entrez
285231
canonical
uniprot
Q6X9E4
canonical
ensembl
ENSG00000164049
resolver
ensp
ENSP00000296438
resolver
ensp
ENSP00000406139
resolver
ensp
ENSP00000414683
resolver
genesymbol
FBXW12
resolver
genesymbol_syn
FBW12
resolver
genesymbol_syn
FBXO12
resolver
genesymbol_syn
FBXO35
resolver
hgnc
HGNC:20729
resolver
uniprot
E9PG36
resolver
uniprot
Q494Y9
resolver
uniprot
Q494Z0
resolver
uniprot_entry
FBW12_HUMAN
resolver
uniprot_sec
E9PG36
resolver
uniprot_sec
Q494Y9
resolver
uniprot_sec
Q494Z0
resolver
amino_acid_sequence
MEIRLPDLALKRIFSFLDLFGLLQVSQVNKHWNRIADSDYLWRSLSLQRWDCSNFTNQHLGTHTWKQFFLHQRRKELRLALAQPHNFIYKVTKNIAFETELAYLSGNRLTVDEQEKSIICSVSPKQELCAWDVQEGTMIWSSPVQEFHFSNLVTLPQMHLAITMDRKKTIKVWNCQDRDALAVLPMPQPCYCMEAYLTKDGPFLMVGDAAGDIYTFTLPGLRDVSKVTAFQYGIVLLHCSPDKKWVFACGTYSRTLPQVFLTESLLRPSEGSVPLSTFLPHKLCASACWTPKVKNRITLMSQSSTGKKTEFITFDLTTKKTGGQTVIQAYEIASFQVAAHLKCPIWMGASDGYMIVFTSGPYLLLFSITGFLLQRFEDHQAAINNFWVDPCYVLTTSENSVHVYMWEEGGRHPYLRSCCHLENTWHDHTTDSCISSVMCDNASIVLRVRKVSDSSILVMYSLNT
uniprot
proteins
function
FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (PubMed:26171402). Promotes degradation of interleukin-22 receptor subunit IL22RA1 in resting and IL22-stimulated conditions by facilitating its ubiquitination (PubMed:26171402). Functions as a cell growth suppressor (PubMed:26171402). {ECO:0000269|PubMed:26171402}.
uniprot
proteins
mass_dalton
53056
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:26171402}.
uniprot
proteins
pubmed
15040455
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
26171402
uniprot
proteins
sequence_length
464
uniprot
proteins