Cops8
entrez
108679
canonical
uniprot
Q8VBV7
canonical
ensembl
ENSMUSG00000034432
resolver
ensp
ENSMUSP00000035884
resolver
enst
ENSMUST00000036153
resolver
genesymbol
Cops8
resolver
genesymbol_syn
Csn8
resolver
uniprot
Q3TRS9
resolver
uniprot
Q80XF4
resolver
uniprot
Q8R4D2
resolver
uniprot_entry
CSN8_MOUSE
resolver
uniprot_sec
Q3TRS9
resolver
uniprot_sec
Q80XF4
resolver
uniprot_sec
Q8R4D2
resolver
amino_acid_sequence
MPVAVMADNAFSFRKLLDQCENQELEAPGGIATPPVYGQLLALYLLQNDMNNARYLWKRIPPAIKSANSELGGIWSVGQRIWQRDFPGIYTTINAHQWSETVQPIMEALRDATRRRAFALVSQAYTSIIADDFAAFVGLPVEEAVKGVLEQGWQADSTTRMVLPRKPASGTLDVSLNRFIPLSEPAPVPPIPNEQQLARLTDYVAFLEN
uniprot
proteins
function
FUNCTION: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
23256
uniprot
proteins
protein_family
CSN8 family
uniprot
proteins
pubmed
14636993
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9707402
uniprot
proteins
sequence_length
209
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
uniprot
proteins