RBM39
entrez
9584
canonical
uniprot
Q14498
canonical
ensembl
ENSG00000131051
resolver
ensp
ENSP00000253363
resolver
ensp
ENSP00000344581
resolver
ensp
ENSP00000354437
resolver
ensp
ENSP00000436747
resolver
ensp
ENSP00000532956
resolver
ensp
ENSP00000532957
resolver
ensp
ENSP00000532966
resolver
ensp
ENSP00000532967
resolver
ensp
ENSP00000583221
resolver
genesymbol
RBM39
resolver
genesymbol_syn
HCC1
resolver
genesymbol_syn
RNPC2
resolver
hgnc
HGNC:15923
resolver
uniprot
A0A384NQ03
resolver
uniprot
A2RRD3
resolver
uniprot
A5D8W2
resolver
uniprot
B0BLV3
resolver
uniprot
B4DRA0
resolver
uniprot
E1P5S0
resolver
uniprot
E1P5S1
resolver
uniprot
Q14499
resolver
uniprot_entry
A0A384NQ03_HUMAN
resolver
uniprot_entry
B4DRA0_HUMAN
resolver
uniprot_entry
RBM39_HUMAN
resolver
uniprot_sec
A2RRD3
resolver
uniprot_sec
A5D8W2
resolver
uniprot_sec
B0BLV3
resolver
uniprot_sec
E1P5S0
resolver
uniprot_sec
E1P5S1
resolver
uniprot_sec
Q14499
resolver
amino_acid_sequence
MADDIDIEAMLEAPYKKDENKLSSANGHEERSKKRKKSKSRSRSHERKRSKSKERKRSRDRERKKSKSRERKRSRSKERRRSRSRSRDRRFRGRYRSPYSGPKFNSAIRGKIGLPHSIKLSRRRSRSKSPFRKDKSPVREPIDNLTPEERDARTVFCMQLAARIRPRDLEEFFSTVGKVRDVRMISDRNSRRSKGIAYVEFVDVSSVPLAIGLTGQRVLGVPIIVQASQAEKNRAAAMANNLQKGSAGPMRLYVGSLHFNITEDMLRGIFEPFGRIESIQLMMDSETGRSKGYGFITFSDSECAKKALEQLNGFELAGRPMKVGHVTERTDASSASSFLDSDELERTGIDLGTTGRLQLMARLAEGTGLQIPPAAQQALQMSGSLAFGAVAEFSFVIDLQTRLSQQTEASALAAAASVQPLATQCFQLSNMFNPQTEEEVGWDTEIKDDVIEECNKHGGVIHIYVDKNSAQGNVYVKCPSIAAAIAAVNALHGRWFAGKMITAAYVPLPTYHNLFPDSMTATQLLVPSRR
uniprot
proteins
function
FUNCTION: RNA-binding protein that acts as a pre-mRNA splicing factor (PubMed:15694343, PubMed:24795046, PubMed:28302793, PubMed:28437394, PubMed:31271494). Acts by promoting exon inclusion via regulation of exon cassette splicing (PubMed:31271494). Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity (By similarity). {ECO:0000250|UniProtKB:Q8VH51, ECO:0000269|PubMed:15694343, ECO:0000269|PubMed:24795046, ECO:0000269|PubMed:28302793, ECO:0000269|PubMed:28437394, ECO:0000269|PubMed:31271494}.
uniprot
proteins
mass_dalton
59380
uniprot
proteins
post_translational_modification
PTM: Aryl sulfonamide anticancer drugs, such as indisulam (E7070) or E7820, promote ubiquitination and subsequent degradation by the DCX(DCAF15) complex (PubMed:28302793, PubMed:28437394, PubMed:31693891). RBM39 degradation results in splicing defects and death in cancer cell lines (PubMed:28302793, PubMed:28437394, PubMed:31693891). Aryl sulfonamide anticancer drugs change the substrate specificity of DCAF15 by acting as a molecular glue that promotes binding between DCAF15 and weak affinity interactor RBM39 (PubMed:31686031, PubMed:31819272). {ECO:0000269|PubMed:28302793, ECO:0000269|PubMed:28437394, ECO:0000269|PubMed:31686031, ECO:0000269|PubMed:31693891, ECO:0000269|PubMed:31819272}.
uniprot
proteins
protein_family
Splicing factor SR family
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15694343
uniprot
proteins
pubmed
15798186
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24795046
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28302793
uniprot
proteins
pubmed
28437394
uniprot
proteins
pubmed
28546157
uniprot
proteins
pubmed
31271494
uniprot
proteins
pubmed
31686031
uniprot
proteins
pubmed
31693891
uniprot
proteins
pubmed
31693911
uniprot
proteins
pubmed
31819272
uniprot
proteins
pubmed
8227358
uniprot
proteins
sequence_length
530
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:8227358}. Note=Concentrated in nuclear speckles (PubMed:8227358). Colocalizes with the core spliceosomal snRNP proteins (PubMed:8227358). {ECO:0000269|PubMed:8227358}.
uniprot
proteins