Macroh2a1
entrez
26914
canonical
uniprot
Q9QZQ8
canonical
ensembl
ENSMUSG00000015937
resolver
ensp
ENSMUSP00000016081
resolver
ensp
ENSMUSP00000038221
resolver
ensp
ENSMUSP00000299816
resolver
ensp
ENSMUSP00000299817
resolver
ensp
ENSMUSP00000299831
resolver
ensp
ENSMUSP00000299842
resolver
genesymbol
Macroh2a1
resolver
genesymbol_syn
H2afy
resolver
uniprot
Q8CA90
resolver
uniprot
Q91VZ2
resolver
uniprot
Q9CTH9
resolver
uniprot
Q9QZQ7
resolver
uniprot_entry
H2AY_MOUSE
resolver
uniprot_entry
Q8CA90_MOUSE
resolver
uniprot_entry
Q9CTH9_MOUSE
resolver
uniprot_sec
Q91VZ2
resolver
uniprot_sec
Q9QZQ7
resolver
amino_acid_sequence
MSSRGGKKKSTKTSRSAKAGVIFPVGRMLRYIKKGHPKYRIGVGAPVYMAAVLEYLTAEILELAGNAARDNKKGRVTPRHILLAVANDEELNQLLKGVTIASGGVLPNIHPELLAKKRGSKGKLEAIITPPPAKKAKSPSQKKPVAKKTGGKKGARKSKKKQGEVSKAASADSTTEGTPTDGFTVLSTKSLFLGQKLQVVQADIASIDSDAVVHPTNTDFYTGGEVGNTLEKKGGKEFVEAVLELRKKNGPLEVAGAAISAGHGLPAKFVIHCNSPVWGADKCEELLEKTVKNCLALADDRKLKSIAFPSIGSGRNGFPKQTAAQLILKAISSYFVSTMSSSIKTVYFMLFDSESIGIYVQEMAKLDAN
uniprot
proteins
function
FUNCTION: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription (By similarity). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (By similarity). Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (By similarity). DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Involved in stable X chromosome inactivation (By similarity). Inhibits the binding of transcription factors, including NF-kappa-B, and interferes with the activity of remodeling SWI/SNF complexes (By similarity). Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin (PubMed:16107708). {ECO:0000250|UniProtKB:O75367, ECO:0000269|PubMed:16107708}.; FUNCTION: [Isoform 1]: Isoform that specifically binds poly-ADP-ribose and O-acetyl-ADP-ribose and plays a key role in NAD(+) metabolism (PubMed:28991266, PubMed:34887560). Able to bind to the ends of poly-ADP-ribose chains created by PARP1 and cap them (PubMed:28991266). This prevents PARP1 from further addition of ADP-ribose and thus limits the consumption of nuclear NAD(+), allowing the cell to maintain proper NAD(+) levels in both the nucleus and the mitochondria to promote proper mitochondrial respiration (PubMed:28991266). Increases the expression of genes involved in redox metabolism, including SOD3 (PubMed:23022728). {ECO:0000269|PubMed:23022728, ECO:0000269|PubMed:28991266, ECO:0000269|PubMed:34887560}.; FUNCTION: [Isoform 2]: In contrast to isoform 1, does not bind poly-ADP-ribose (By similarity). Represses SOD3 gene expression (PubMed:23022728). {ECO:0000250|UniProtKB:O75367, ECO:0000269|PubMed:23022728}.
uniprot
proteins
mass_dalton
39290
uniprot
proteins
mutagenesis
MUTAGEN 224; /note="G->E: Abolished ability to bind poly-ADP-ribose and inhibit PARP1."; /evidence="ECO:0000269|PubMed:28991266
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated at either Lys-116 or Lys-117. May also be polyubiquitinated. Ubiquitination is mediated by the CUL3/SPOP E3 complex and does not promote proteasomal degradation. Instead, it is required for enrichment in inactive X chromosome chromatin. {ECO:0000250|UniProtKB:O75367}.
uniprot
proteins
protein_family
Histone H2A family
uniprot
proteins
pubmed
10471737
uniprot
proteins
pubmed
11262398
uniprot
proteins
pubmed
12183056
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15564378
uniprot
proteins
pubmed
16107708
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23022728
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
28991266
uniprot
proteins
pubmed
34887560
uniprot
proteins
pubmed
9634239
uniprot
proteins
sequence_length
369
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15564378, ECO:0000269|PubMed:9634239}. Chromosome {ECO:0000269|PubMed:15564378, ECO:0000269|PubMed:9634239}. Note=Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin (PubMed:9634239). In quiescent lymphocytes, associated with centromeric constitutive heterochromatin (PubMed:15564378). Recruited to DNA damage sites in an APLF-dependent manner (By similarity). {ECO:0000250|UniProtKB:O75367, ECO:0000269|PubMed:15564378, ECO:0000269|PubMed:9634239}.
uniprot
proteins