Tjp2
entrez
21873
canonical
uniprot
Q9Z0U1
canonical
ensembl
ENSMUSG00000024812
resolver
ensp
ENSMUSP00000097154
resolver
ensp
ENSMUSP00000156605
resolver
ensp
ENSMUSP00000156728
resolver
ensp
ENSMUSP00000208392
resolver
ensp
ENSMUSP00000208393
resolver
ensp
ENSMUSP00000208403
resolver
ensp
ENSMUSP00000208411
resolver
enst
ENSMUST00000099558
resolver
enst
ENSMUST00000233027
resolver
enst
ENSMUST00000233658
resolver
genesymbol
Tjp2
resolver
genesymbol_syn
Zo2
resolver
uniprot
A0A3B2WCN9
resolver
uniprot
Q8K210
resolver
uniprot_entry
A0A3B2WCN9_MOUSE
resolver
uniprot_entry
ZO2_MOUSE
resolver
uniprot_sec
Q8K210
resolver
amino_acid_sequence
MEEVIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVISDVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKIAAIVVKRPRKVQVAPLQGSPPLSHDDRGFEVIEEFDGRSFRSGYSERSRHSSHDMLSHSWEGNRERGRPHQRTQSRERERSRGRSLERGLDQEDYGRSRERSRGRSLERGLDRDFVSRDHSRGRSIDRDYDRDYERSYHEAYEPDYGGGYSPSYDRRAHPETRYERSRSREHLRSRSPSPESRSRHEHKGQHDPDRPIGVLLTKSKANEEYGLRLGSQIFIKEMTRTGLATKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLRDSKQTLINIPALNDSDSEVEDISEIESNRSFSPEERRQQYSDQDYHSSTEKLKERPSSREETSGRLSRMGATPTPFKSTGDITAAGVTEASREPRYQEEGPVPQPRTAPRVFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDVGIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGETVTILAQSRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGHWLAVRIGNELEKGLIPNKSRAEQMASVQNAQRENAGDRADFWRMRGQRSSGGVKKNLRKSREDLAAAVSVSTKFPAYEKVLLREAGFKRPVVLFGPIADIAMERLATELPDLFQTAKTEPKDAGSEKSSGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTIRQRLSPTSNKSSRKLFDQANKLKKTCSHLFTATINVNSANDGWFGSLKDSIQQQQNEAVWVSEGKMEGMDDDAEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNELEEPAEEPLVSSITRSSEPVQHEENIRKSSPEPRAQMRRAASRDQLRDASPPPAFKPEPPKARSQNREDSFDYSKSNLPATAGSEIPGGSTKGYPPPIAAKPAFGRPILKPSTPVPMPESEEVGESTEEQEDAPRSVLGRVKIFEKMDHKAKLQRMQELQEAQNARIEIAQKHPDIYAVPIKAPKPDAGLPPHMSSRPPEPQKAPSRLYQDTRGSYGSDPEEEEYRQQLAAHSKRGYYSQPSRYRDTEL
uniprot
proteins
function
FUNCTION: Plays a role in tight junctions and adherens junctions (PubMed:10026224). Acts as a positive regulator of RANKL-induced osteoclast differentiation, potentially via mediating downstream transcriptional activity (PubMed:22437732). {ECO:0000269|PubMed:10026224, ECO:0000269|PubMed:22437732}.
uniprot
proteins
mass_dalton
131280
uniprot
proteins
protein_family
MAGUK family
uniprot
proteins
pubmed
10026224
uniprot
proteins
pubmed
12403786
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22437732
uniprot
proteins
pubmed
26609154
uniprot
proteins
sequence_length
1167
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000269|PubMed:10026224}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus {ECO:0000269|PubMed:22437732}. Cell junction, tight junction {ECO:0000269|PubMed:10026224, ECO:0000269|PubMed:26609154}. Note=Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures. Localizes to tight junctions during initial stages of their formation (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q95168}.
uniprot
proteins