Nmnat1
entrez
66454
canonical
uniprot
Q9EPA7
canonical
ensembl
ENSMUSG00000028992
resolver
ensp
ENSMUSP00000030845
resolver
ensp
ENSMUSP00000101318
resolver
enst
ENSMUST00000030845
resolver
enst
ENSMUST00000105693
resolver
genesymbol
Nmnat1
resolver
genesymbol_syn
D4Cole1e
resolver
genesymbol_syn
Nmnat
resolver
uniprot
Q3V449
resolver
uniprot
Q6B504
resolver
uniprot_entry
NMNA1_MOUSE
resolver
uniprot_entry
Q3V449_MOUSE
resolver
uniprot_sec
Q6B504
resolver
activity_regulation
ACTIVITY REGULATION: Activity is strongly inhibited by galotannin. Inhibited by P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate (Nap4AD). {ECO:0000250|UniProtKB:Q9HAN9}.
uniprot
proteins
amino_acid_sequence
MDSSKKTEVVLLACGSFNPITNMHLRLFELAKDYMHATGKYSVIKGIISPVGDAYKKKGLIPAHHRIIMAELATKNSHWVEVDTWESLQKEWVETVKVLRYHQEKLATGSCSYPQSSPALEKPGRKRKWADQKQDSSPQKPQEPKPTGVPKVKLLCGADLLESFSVPNLWKMEDITQIVANFGLICITRAGSDAQKFIYESDVLWRHQSNIHLVNEWITNDISSTKIRRALRRGQSIRYLVPDLVQEYIEKHELYNTESEGRNAGVTLAPLQRNAAEAKHNHSTL
uniprot
proteins
ec_number
2.7.7.1
uniprot
proteins
ec_number
2.7.7.18
uniprot
proteins
function
FUNCTION: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:15381699, PubMed:19403820, PubMed:27735788). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency (By similarity). Can use triazofurin monophosphate (TrMP) as substrate (By similarity). Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+) (By similarity). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively (By similarity). Involved in the synthesis of ATP in the nucleus, together with PARP1, PARG and NUDT5 (By similarity). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (By similarity). Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (By similarity). Also acts as a cofactor for glutamate and aspartate ADP-ribosylation by directing PARP1 catalytic activity to glutamate and aspartate residues on histones (PubMed:32822587). Protects against axonal degeneration following mechanical or toxic insults (PubMed:15310905, PubMed:16914673, PubMed:19403820, PubMed:22425156). Delays axonal degeneration after axotomy; results in a >10-fold increase in intact neurites 72 hours after injury (PubMed:16914673, PubMed:19403820, PubMed:27735788). Neural protection does not correlate with cellular NAD(+) levels but may still require enzyme activity (PubMed:19403820). {ECO:0000250|UniProtKB:Q9HAN9, ECO:0000269|PubMed:15310905, ECO:0000269|PubMed:15381699, ECO:0000269|PubMed:16914673, ECO:0000269|PubMed:19403820, ECO:0000269|PubMed:22425156, ECO:0000269|PubMed:27735788, ECO:0000269|PubMed:32822587}.
uniprot
proteins
mass_dalton
32355
uniprot
proteins
mutagenesis
MUTAGEN 24; /note="H->A: Significantly reduced enzymatic activity, probably due to reduced ATP binding affinity. Has no axonal protective effect."; /evidence="ECO:0000269|PubMed:19403820"; MUTAGEN 125..128; /note="RKRK->AAAA: Locates to the cytoplasm. Has no effect on enzyme activity or axonal protection."; /evidence="ECO:0000269|PubMed:16914673, ECO:0000269|PubMed:19403820"; MUTAGEN 170; /note="W->A: Decrease in enzyme activity. Has no axonal protective effect. Does not affect ability to promotze glutamate and aspartate ADP-ribosylation."; /evidence="ECO:0000269|PubMed:15310905, ECO:0000269|PubMed:19403820, ECO:0000269|PubMed:32822587
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.; PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.
uniprot
proteins
protein_family
Eukaryotic NMN adenylyltransferase family
uniprot
proteins
pubmed
11027338
uniprot
proteins
pubmed
15310905
uniprot
proteins
pubmed
15381699
uniprot
proteins
pubmed
16914673
uniprot
proteins
pubmed
19403820
uniprot
proteins
pubmed
22425156
uniprot
proteins
pubmed
27735788
uniprot
proteins
pubmed
32822587
uniprot
proteins
sequence_length
285
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16914673}. Cytoplasm {ECO:0000269|PubMed:19403820}. Note=Localizes predominantly to the cytoplasm. {ECO:0000269|PubMed:19403820}.
uniprot
proteins