EIF3K
entrez
27335
canonical
uniprot
Q9UBQ5
canonical
ensembl
ENSG00000178982
resolver
ensembl
ENSG00000282986
resolver
ensp
ENSP00000248342
resolver
ensp
ENSP00000465460
resolver
ensp
ENSP00000468231
resolver
ensp
ENSP00000488959
resolver
ensp
ENSP00000489565
resolver
enst
ENST00000592558
resolver
enst
ENST00000593149
resolver
enst
ENST00000634474
resolver
enst
ENST00000634491
resolver
genesymbol
EIF3K
resolver
genesymbol_syn
EIF3S12
resolver
hgnc
HGNC:24656
resolver
uniprot
A8K0I9
resolver
uniprot
B7ZAM9
resolver
uniprot
K7EK53
resolver
uniprot
K7ERF1
resolver
uniprot
Q96IQ0
resolver
uniprot
Q9Y6D1
resolver
uniprot
U3LUI4
resolver
uniprot_entry
EIF3K_HUMAN
resolver
uniprot_entry
K7EK53_HUMAN
resolver
uniprot_entry
K7ERF1_HUMAN
resolver
uniprot_entry
U3LUI4_HUMAN
resolver
uniprot_sec
A8K0I9
resolver
uniprot_sec
B7ZAM9
resolver
uniprot_sec
Q96IQ0
resolver
uniprot_sec
Q9Y6D1
resolver
amino_acid_sequence
MAMFEQMRANVGKLLKGIDRYNPENLATLERYVETQAKENAYDLEANLAVLKLYQFNPAFFQTTVTAQILLKALTNLPHTDFTLCKCMIDQAHQEERPIRQILYLGDLLETCHFQAFWQALDENMDLLEGITGFEDSVRKFICHVVGITYQHIDRWLLAEMLGDLSDSQLKVWMSKYGWSADESGQIFICSQEESIKPKNIVEKIDFDSVSSIMASSQ
uniprot
proteins
function
FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03010, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.
uniprot
proteins
mass_dalton
25060
uniprot
proteins
protein_family
EIF-3 subunit K family
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
14519125
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15180986
uniprot
proteins
pubmed
15327989
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15703437
uniprot
proteins
pubmed
16766523
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17322308
uniprot
proteins
pubmed
17581632
uniprot
proteins
pubmed
18599441
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25849773
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27462815
uniprot
proteins
sequence_length
218
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03010, ECO:0000269|PubMed:15327989}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03010, ECO:0000269|PubMed:15327989}.
uniprot
proteins