Mcl1
entrez
60430
canonical
uniprot
Q9Z1P3
canonical
ensembl
ENSRNOG00000063678
resolver
ensembl
ENSRNOG00055031621
resolver
ensembl
ENSRNOG00060013230
resolver
ensembl
ENSRNOG00065023492
resolver
ensp
ENSRNOP00000097988
resolver
ensp
ENSRNOP00055045262
resolver
ensp
ENSRNOP00060017868
resolver
ensp
ENSRNOP00065032661
resolver
enst
ENSRNOT00000109758
resolver
enst
ENSRNOT00055054756
resolver
enst
ENSRNOT00060022547
resolver
enst
ENSRNOT00065040157
resolver
genesymbol
Mcl1
resolver
uniprot
Q6AYY5
resolver
uniprot
Q9R289
resolver
uniprot_entry
MCL1_RAT
resolver
uniprot_sec
Q6AYY5
resolver
uniprot_sec
Q9R289
resolver
amino_acid_sequence
MFGLRRNAVIGLNLYCGGASLGAGGGSPAGTRLAAEEAKARREGGGEAALLPGARVVARPPPVGAEDPDVTASAERRLLKSPGLLAVPPEEMAASAAAIMSPEEELDGCEPEVLSKRPAVLPLLERVSEAAKSSGADGSLPSTPPPPEEEDDELYRQSLEIISRYLREQATGSKDAKPLGEAGAAGRRALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSFSRVMTHVFKDGVTNWGRIVTLISFGAFVAKHLKSINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVQDLEGGIRNVLLAFAGVAGVGAGLAYLIR
uniprot
proteins
function
FUNCTION: Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis.
uniprot
proteins
mass_dalton
35214
uniprot
proteins
post_translational_modification
PTM: Cleaved by CASP3 during apoptosis, yielding a pro-apoptotic C-terminal fragment. {ECO:0000250}.; PTM: Rapidly degraded in the absence of phosphorylation in the PEST region. {ECO:0000250}.; PTM: Phosphorylated on Ser-139, by GSK3, in response to IL3/interleukin-3 withdrawal. Phosphorylation at Ser-139 induces ubiquitination and proteasomal degradation, abrogating the anti-apoptotic activity. Treatment with taxol or okadaic acid induces phosphorylation on additional sites (By similarity). {ECO:0000250}.; PTM: Ubiquitinated. Ubiquitination is induced by phosphorylation at Ser-139 (By similarity). Deubiquitinated by USP20; leading to increased stability. {ECO:0000250|UniProtKB:Q07820}.
uniprot
proteins
protein_family
Bcl-2 family
uniprot
proteins
pubmed
10579309
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
330
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Note=Cytoplasmic, associated with mitochondria.
uniprot
proteins
transmembrane_region
TRANSMEM 307..329; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins