NDST2
entrez
8509
canonical
uniprot
P52849
canonical
ensembl
ENSG00000166507
resolver
ensembl
ENSG00000272916
resolver
ensp
ENSP00000310657
resolver
ensp
ENSP00000475031
resolver
enst
ENST00000603027
resolver
genesymbol
NDST2
resolver
genesymbol_syn
HSST2
resolver
hgnc
HGNC:7681
resolver
uniprot
B4E139
resolver
uniprot
Q2TB32
resolver
uniprot
Q59H89
resolver
uniprot
S4R438
resolver
uniprot_entry
B4E139_HUMAN
resolver
uniprot_entry
NDST2_HUMAN
resolver
uniprot_entry
S4R438_HUMAN
resolver
uniprot_sec
Q2TB32
resolver
uniprot_sec
Q59H89
resolver
amino_acid_sequence
MLQLWKVVRPARQLELHRLILLLIAFSLGSMGFLAYYVSTSPKAKEPLPLPLGDCSSGGAAGPGPARPPVPPRPPRPPETARTEPVVLVFVESAYSQLGQEIVAILESSRFRYSTELAPGRGDMPTLTDNTHGRYVLVIYENLLKYVNLDAWSRELLDRYCVEYGVGIIGFFRAHEHSLLSAQLKGFPLFLHSNLGLRDYQVNPSAPLLHLTRPSRLEPGPLPGDDWTIFQSNHSTYEPVLLASLRPAEPAVPGPVLRRARLPTVVQDLGLHDGIQRVLFGHGLSFWLHKLIFVDAVAYLTGKRLCLDLDRYILVDIDDIFVGKEGTRMKVADVEALLTTQNKLRTLVPNFTFNLGFSGKFYHTGTEEEDAGDDMLLKHRKEFWWFPHMWSHMQPHLFHNRSVLADQMRLNKQFALEHGIPTDLGYAVAPHHSGVYPIHTQLYEAWKSVWGIQVTSTEEYPHLRPARYRRGFIHNGIMVLPRQTCGLFTHTIFYNEYPGGSRELDRSIRGGELFLTVLLNPISIFMTHLSNYGNDRLGLYTFESLVRFLQCWTRLRLQTLPPVPLAQKYFELFPQERSPLWQNPCDDKRHKDIWSKEKTCDRLPKFLIVGPQKTGTTAIHFFLSLHPAVTSSFPSPSTFEEIQFFNSPNYHKGIDWYMDFFPVPSNASTDFLFEKSATYFDSEVVPRRGAALLPRAKIITVLTNPADRAYSWYQHQRAHGDPVALNYTFYQVISASSQTPLALRSLQNRCLVPGYYSTHLQRWLTYYPSGQLLIVDGQELRTNPAASMESIQKFLGITPFLNYTRTLRFDDDKGFWCQGLEGGKTRCLGRSKGRRYPDMDTESRLFLTDFFRNHNLELSKLLSRLGQPVPSWLREELQHSSLG
uniprot
proteins
ec_number
2.8.2.8
uniprot
proteins
ec_number
3.5.1.-
uniprot
proteins
function
FUNCTION: Essential bifunctional enzyme that catalyzes both the N-deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate (By similarity). Exhibits N-deacetylase activity (PubMed:16343444). Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis (By similarity). Plays a role in determining the extent and pattern of sulfation of heparan sulfate (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). Essential for the biosynthesis of sulfated heparin in mast cells, thereby enabling proper secretory granule formation and storage of mast-cell proteases (By similarity). {ECO:0000250|UniProtKB:P52848, ECO:0000250|UniProtKB:P52850, ECO:0000269|PubMed:16343444, ECO:0000269|PubMed:22660413}.
uniprot
proteins
mass_dalton
100875
uniprot
proteins
pathway_participation
PATHWAY: Glycan metabolism; heparan sulfate biosynthesis.; PATHWAY: Glycan metabolism; heparin biosynthesis.
uniprot
proteins
protein_family
NDST subfamily
uniprot
proteins
protein_family
Sulfotransferase 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16343444
uniprot
proteins
pubmed
22660413
uniprot
proteins
pubmed
9601056
uniprot
proteins
sequence_length
883
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q02353}; Single-pass type II membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 19..39; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins