HSD17B14
entrez
51171
canonical
uniprot
Q9BPX1
canonical
ensembl
ENSG00000087076
resolver
ensp
ENSP00000263278
resolver
ensp
ENSP00000469557
resolver
ensp
ENSP00000657625
resolver
enst
ENST00000263278
resolver
genesymbol
HSD17B14
resolver
genesymbol_syn
DHRS10
resolver
genesymbol_syn
SDR3
resolver
genesymbol_syn
SDR47C1
resolver
hgnc
HGNC:23238
resolver
uniprot
A0A140VJH8
resolver
uniprot
Q9UKU3
resolver
uniprot_entry
A0A140VJH8_HUMAN
resolver
uniprot_entry
DHB14_HUMAN
resolver
uniprot_sec
Q9UKU3
resolver
amino_acid_sequence
MATGTRYAGKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAVFILCDVTQEDDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLTKLALPYLRKSQGNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVRVNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLASEANFCTGIELLVTGGAELGYGCKASRSTPVDAPDIPS
uniprot
proteins
ec_number
1.1.1.122
uniprot
proteins
function
FUNCTION: Catalyzes the NAD(+)-dependent oxidation of L-fucose, yielding L-fucono-1,5-lactone, which rapidly converts spontaneously to L-fucone-1,4-lactone. Can also act on D-arabinose and L-galactose, with lower catalytic efficiency (PubMed:38944119). Does not use NADPH (PubMed:38944119). May be the initial enzyme of the L-fucose degradation pathway in mammals (PubMed:17067289, PubMed:38944119). {ECO:0000269|PubMed:17067289, ECO:0000269|PubMed:38944119}.
uniprot
proteins
mass_dalton
28317
uniprot
proteins
mutagenesis
MUTAGEN 93; /note="H->A: Increases kcat for androst-5-en-3beta,17beta-diol and 17beta-estradiol."; /evidence="ECO:0000269|PubMed:30836176"; MUTAGEN 148; /note="Q->A: The catalytic efficiency (kcat/Km) increases 30-fold for 17beta-estradiol and 11-fold for androst-5-en-3beta,17beta-diol."; /evidence="ECO:0000269|PubMed:30836176"; MUTAGEN 158; /note="K->A: Lacks testosterone 17-beta-dehydrogenase (NADP+) and estradiol 17-beta-dehydrogenase [NAD(P)+] activities."; /evidence="ECO:0000269|PubMed:30836176"; MUTAGEN 253; /note="Y->A: Lacks testosterone 17-beta-dehydrogenase (NADP+) and estradiol 17-beta-dehydrogenase [NAD(P)+] activities."; /evidence="ECO:0000269|PubMed:30836176"; MUTAGEN 255; /note="C->A: Does not affect kcat for androst-5-en-3beta,17beta-diol and 17beta-estradiol."; /evidence="ECO:0000269|PubMed:30836176
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate degradation; L-fucose degradation. {ECO:0000305}.
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
10800688
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17067289
uniprot
proteins
pubmed
27362750
uniprot
proteins
pubmed
27933965
uniprot
proteins
pubmed
29859505
uniprot
proteins
pubmed
30836176
uniprot
proteins
pubmed
38944119
uniprot
proteins
sequence_length
270
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17067289}.
uniprot
proteins