Tmem164
entrez
209497
canonical
uniprot
Q6PHN7
canonical
ensembl
ENSMUSG00000047045
resolver
ensp
ENSMUSP00000084591
resolver
ensp
ENSMUSP00000098759
resolver
ensp
ENSMUSP00000108510
resolver
ensp
ENSMUSP00000108517
resolver
ensp
ENSMUSP00000138503
resolver
ensp
ENSMUSP00000261758
resolver
ensp
ENSMUSP00000261763
resolver
ensp
ENSMUSP00000261765
resolver
enst
ENSMUST00000087333
resolver
enst
ENSMUST00000101198
resolver
enst
ENSMUST00000112889
resolver
enst
ENSMUST00000112896
resolver
enst
ENSMUST00000133634
resolver
genesymbol
Tmem164
resolver
genesymbol_syn
AW547186
resolver
uniprot
A2AH99
resolver
uniprot
Q3TLI7
resolver
uniprot_entry
A2AH99_MOUSE
resolver
uniprot_entry
Q3TLI7_MOUSE
resolver
uniprot_entry
TM164_MOUSE
resolver
amino_acid_sequence
MSRYSYQSLLDWLYGGVDPSFAGNGGPDCAAFLSWQQRLLESVVVLTLALLEILVALRHILRQKEDGRGGRSSQPQQVTQRPEEGKESLSKNLLLVALCLIFGVEVGFKFATKTVIYLLNPCHLVTMMHIFLLACPPCPGATVIFKLQMHMLNGALLALLFPVVNTRLLPFELEIYYIQHAMLYVVPVYLLWKGGAYTPEPLCNFQWALLSTGLMFFYHFSFLQILGLVTEVNLNNMLCPAISDPFYGPWYRIWASGHQTLMTMTHGKLVILFSYMAGPLCKYLLDLLRLPAKKID
uniprot
proteins
function
FUNCTION: Positive regulator of ferroptosis. Involved in the acylation of ether lysophospholipids with the arachidonoyl chain (5Z,8Z,11Z,14Z-eicosatetraenoyl; C20:4) of diacylglycerophospholipids, generating C20:4 ether glycerophospholipids (ePEs) such as 1-(1Z-octadecenyl)-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine (PE (P-18:0/20:4)), which promotes ferroptosis. Selectively mediates ATG5-dependent autophagosome formation during ferroptosis, rather than during starvation, and regulates the degradation of ferritin, GPX4 and lipid droplets to increase iron accumulation and lipid peroxidation, thereby promoting ferroptotic cell death. {ECO:0000250|UniProtKB:Q5U3C3}.
uniprot
proteins
mass_dalton
33441
uniprot
proteins
protein_family
TMEM164 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
296
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..60; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 92..112; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 125..145; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 149..169; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 171..191; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 209..229; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 261..281; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins