SPOCD1
entrez
90853
canonical
uniprot
Q6ZMY3
canonical
ensembl
ENSG00000134668
resolver
ensp
ENSP00000257100
resolver
ensp
ENSP00000353670
resolver
ensp
ENSP00000587938
resolver
ensp
ENSP00000758333
resolver
genesymbol
SPOCD1
resolver
hgnc
HGNC:26338
resolver
uniprot
Q24JU3
resolver
uniprot
Q6PI90
resolver
uniprot
Q8N869
resolver
uniprot
Q8N8U0
resolver
uniprot
Q8NBC6
resolver
uniprot
Q96LN6
resolver
uniprot_entry
SPOC1_HUMAN
resolver
uniprot_sec
Q24JU3
resolver
uniprot_sec
Q6PI90
resolver
uniprot_sec
Q8N869
resolver
uniprot_sec
Q8N8U0
resolver
uniprot_sec
Q8NBC6
resolver
uniprot_sec
Q96LN6
resolver
amino_acid_sequence
MSQAGDVEGPSTGDPVLSPQHNCELLQNMEGASSMPGLSPDGPGASSGPGVRAGSRRKIPRKEALRGGSSRAAGAAEVRPGVLELLAVVQSRGSMLAPGLHMQLPSVPTQGRALTSKRLQVSLCDILDDSCPRKLCSRSAGLPERALACRERLAGVEEVSCLRPREARDGGMSSPGCDRRSPTLSKEEPPGRPLTSSPDPVPVRVRKKWRRQGAHSECEEGAGDFLWLDQSPRGDNLLSVGDPPQVADLESLGGPCRPPSPKDTGSGPGEPGGSGAGCASGTEKFGYLPATGDGPQPGSPCGPVGFPVPSGGESLSSAAQAPPQSAALCLGASAQASAEQQEAVCVVRTGSDEGQAPAQDQEELEAKAQPASRGRLEQGLAAPADTCASSREPLGGLSSSLDTEASRACSGPFMEQRRSKGTKNLKKGPVPCAQDRGTDRSSDNSHQDRPEEPSPGGCPRLEEVKIPHGVKLVCYLGSGPVIQLLGAISHGQAGGQLPPKLEVLEDLMEVSSPSPAQRLRRKKRPMVQGPAGCQVFQPSPSGGTAGDPGGLSDPFYPPRSGSLALGDPSSDPACSQSGPMEAEEDSLPEQPEDSAQLQQEKPSLYIGVRGTVVRSMQEVLWTRLRELPDPVLSEEVVEGIAAGIEAALWDLTQGTNGRYKTKYRSLLFNLRDPRNLDLFLKVVHGDVTPYDLVRMSSMQLAPQELARWRDQEEKRGLNIIEQQQKEPCRLPASKMTHKGEVEIQRDMDQTLTLEDLVGPQMFMDCSPQALPIASEDTTGQHDHHFLDPNCHICKDWEPSNELLGSFEAAKSCGDNIFQKALSQTPMPAPEMPKTRELSPTEPQDRVPPSGLHVPAAPTKALPCLPPWEGVLDMFSIKRFRARAQLVSGHSCRLVQALPTVIRSAGCIPSNIVWDLLASICPAKAKDVCVVRLCPHGARDTQNCRLLYSYLNDRQRHGLASVEHMGMVLLPLPAFQPLPTRLRPLGGPGLWALPVSPLLSPGLEVTHSSLLLAVLLPKEGLPDTAGSSPWLGKVQKMVSFNSKVEKRYYQPDDRRPNVPLKGTPPPGGAWQQSQGRGSIAPRGISAWQRPPRGRGRLWPEPENWQHPGRGQWPPEPGLRQSQHPYSVAPAGHGFGRGQHFHRDSCPHQALLRHLESLATMSHQLQALLCPQTKSSIPRPLQRLSSALAAPEPPGPARDSSLGPTDEAGSECPFPRKA
uniprot
proteins
disease_involvement
DISEASE: Note=Spermatogenic failure (PubMed:38359823). A male infertility disorder caused by spermatogenesis defects that result in non-obstructive azoospermia (PubMed:38359823). The disease is caused by variants affecting the gene represented in this entry (PubMed:38359823). {ECO:0000269|PubMed:38359823}.
uniprot
proteins
function
FUNCTION: Protein adapter that acts as an essential executor of PIWIL4-piRNA pathway directed transposon DNA methylation and silencing in the male embryonic germ cells (PubMed:38359823). Recruited to young transposons, which are specifically marked with histone H3 trimethylated at both 'Lys-4' and 'Lys-9' (H3K4me3K9me3), via its association with SPIN1 chromatin reader, and associates with the de novo DNA methylation machinery and repressive chromatin remodeling complexes (By similarity). Following this, PIWIL4 engages with nascent transposable element transcript to direct piRNA-directed DNA methylation. Not required for piRNA biosynthesis (By similarity). {ECO:0000250|UniProtKB:B1ASB6, ECO:0000269|PubMed:38359823}.
uniprot
proteins
mass_dalton
130027
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
38359823
uniprot
proteins
sequence_length
1216
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:B1ASB6}. Chromosome {ECO:0000250|UniProtKB:B1ASB6}.
uniprot
proteins