Has3
entrez
15118
canonical
uniprot
O08650
canonical
ensembl
ENSMUSG00000031910
resolver
ensp
ENSMUSP00000034385
resolver
ensp
ENSMUSP00000135303
resolver
enst
ENSMUST00000034385
resolver
enst
ENSMUST00000176144
resolver
genesymbol
Has3
resolver
uniprot
Q8CEB9
resolver
uniprot_entry
HYAS3_MOUSE
resolver
uniprot_sec
Q8CEB9
resolver
amino_acid_sequence
MPVQLTTALRVVGTSLFALVVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQSLFAFLEHRRMRRAGRPLKLHCSQRPRSVALCIAAYQEDPEYLRKCLRSAQRIAFPNLKVVMVVDGNRQEDTYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMERVRAVVWASTFSCIMQKWGGKREVMYTAFKALGNSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGGVGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYFGCVQCISGPLGMYRNSLLQQFLEDWYHQKFLGSKCSFGDDRHLTNRVLSLGYRTKYTARSKCLTETPTRYLRWLNQQTRWSKSYFREWLYNSLWFHKHHLWMTYESVVTGFFPFFLIATVIQLFYRGRIWNILLFLLTVQLVGIIKATYACFLRGNAEMIFMSLYSLLYMSSLLPAKIFAIATINKSGWGTSGRKTIVVNFIGLIPVSIWVAVLLGGLAYTAYCQDLFSETELAFLVSGAILYGCYWVALLMLYLAIIARRCGKKPEQYSLAFAEV
uniprot
proteins
ec_number
2.4.1.212
uniprot
proteins
function
FUNCTION: Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of three isoenzymes responsible for cellular hyaluronan synthesis. {ECO:0000269|PubMed:10455188, ECO:0000269|PubMed:16014622}.
uniprot
proteins
mass_dalton
63349
uniprot
proteins
mutagenesis
MUTAGEN 216; /note="D->A: Not detectable on the plasma membrane. Abolishes hyaluronan synthase activity."; /evidence="ECO:0000269|PubMed:16014622
uniprot
proteins
pathway_participation
PATHWAY: Glycan biosynthesis; hyaluronan biosynthesis. {ECO:0000269|PubMed:10455188, ECO:0000269|PubMed:16014622}.
uniprot
proteins
post_translational_modification
PTM: O-GlcNAcylation increases the hyaluronan synthase activity, HAS3 stability and its plasma membrane residence. The concentration of UDP-GlcNAc controls the level of O-GlcNAc modification. {ECO:0000250|UniProtKB:O00219}.
uniprot
proteins
protein_family
NodC/HAS family
uniprot
proteins
pubmed
10455188
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16014622
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
24790187
uniprot
proteins
pubmed
9083017
uniprot
proteins
sequence_length
554
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10455188, ECO:0000269|PubMed:16014622}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:16014622}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:16014622}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle {ECO:0000269|PubMed:16014622}. Note=Travels through endoplasmic reticulum (ER), Golgi, plasma membrane, and endocytic vesicles (PubMed:16014622). Active only when present in plasma membrane (PubMed:16014622). O-GlcNAcylation controls its membrane localization (By similarity). A rapid recycling of HAS3 between plasma membrane and endosomes is controlled by the cytosolic levels of UDP-GlcUA and UDP-GlcNAc (By similarity). {ECO:0000250|UniProtKB:O00219, ECO:0000269|PubMed:16014622}.
uniprot
proteins
transmembrane_region
TRANSMEM 16..36; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 45..65; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 379..399; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 410..430; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 442..462; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 475..495; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 517..537; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins