Pms2
entrez
18861
canonical
uniprot
P54279
canonical
ensembl
ENSMUSG00000075569
resolver
ensembl
ENSMUSG00000079109
resolver
ensp
ENSMUSP00000119875
resolver
ensp
ENSMUSP00000132687
resolver
ensp
ENSMUSP00000148444
resolver
ensp
ENSMUSP00000319009
resolver
enst
ENSMUST00000148011
resolver
genesymbol
Pms2
resolver
uniprot
B9EJ22
resolver
uniprot_entry
PMS2_MOUSE
resolver
uniprot_sec
B9EJ22
resolver
amino_acid_sequence
MEQTEGVSTECAKAIKPIDGKSVHQICSGQVVLSLSTAVKELIENSVDAGATTIDLRLKDYGVDLIEVSDNGCGVEEENFEGLALKHHTSKIQEFADLTQVETFGFRGEALSSLCALSDVTISTCHGSASVGTRLVFDHNGKITQKTPYPRPKGTTVSVQHLFYTLPVRYKEFQRNIKKEYAKMVQVLQAYCIISAGVRVSCTNQLGQGKRQPVVCTSGSSGMKENIGSVFGQKQLQSLIPFVQLPPSDAVCEEYGLSTSRTPQNLFYVSGFISQCTHGAGRSATDRQFFFINQRPCDPAKVSKLVNEVYHMYNRHQYPFVVLNVSVDSECVDINVTPDKRQILLQEEKLLLAVLKTSLIGMFDSDANKLNVNQQPLLDVEGNLVKLHTAELEKPVPGKQDNSPSLKSTADEKRVASISRLREAFSLHPTKEIKSRGPETAELTRSFPSEKRGVLSSYPSDVISYRGLRGSQDKLVSPTDSPGDCMDREKIEKDSGLSSTSAGSEEGFSTPEVASSFSSDYNVSSPEDRPSQETINCGDLDCRPPGTGQSLKPEDHGYQCKALPLARLSPTNAKRFKTEERPSNVNISQRLPGPQSTSAAEVDVAIKMNKRIVLLEFSLSSLAKRMKQLQHLKAQNKHELSYRKFRAKICPGENQAAEDELRKEISKSMFAEMEILGQFNLGFIVTKLKEDLFLVDQHAADEKYNFEMLQQHTVLQAQRLITPQTLNLTAVNEAVLIENLEIFRKNGFDFVIDEDAPVTERAKLISLPTSKNWTFGPQDIDELIFMLSDSPGVMCRPSRVRQMFASRACRKSVMIGTALNASEMKKLITHMGEMDHPWNCPHGRPTMRHVANLDVISQN
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Possesses an ATPase activity, but in the absence of gross structural changes, ATP hydrolysis may not be necessary for proficient mismatch repair (By similarity). {ECO:0000250|UniProtKB:P54278}.
uniprot
proteins
mass_dalton
95298
uniprot
proteins
protein_family
DNA mismatch repair MutL/HexB family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
7628019
uniprot
proteins
sequence_length
859
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P54278}.
uniprot
proteins