CD28
entrez
940
canonical
uniprot
P10747
canonical
ensembl
ENSG00000178562
resolver
ensp
ENSP00000324890
resolver
ensp
ENSP00000363605
resolver
ensp
ENSP00000393648
resolver
genesymbol
CD28
resolver
hgnc
HGNC:1653
resolver
uniprot
A8KAC1
resolver
uniprot
B4E0L1
resolver
uniprot
Q13964
resolver
uniprot
Q52M23
resolver
uniprot
Q70WG0
resolver
uniprot
Q8NI54
resolver
uniprot
Q8NI55
resolver
uniprot
Q8NI56
resolver
uniprot
Q8WXJ2
resolver
uniprot
Q9BYV0
resolver
uniprot_entry
B4E0L1_HUMAN
resolver
uniprot_entry
CD28_HUMAN
resolver
uniprot_sec
A8KAC1
resolver
uniprot_sec
Q13964
resolver
uniprot_sec
Q52M23
resolver
uniprot_sec
Q70WG0
resolver
uniprot_sec
Q8NI54
resolver
uniprot_sec
Q8NI55
resolver
uniprot_sec
Q8NI56
resolver
uniprot_sec
Q8WXJ2
resolver
uniprot_sec
Q9BYV0
resolver
amino_acid_sequence
MLRLLLALNLFPSIQVTGNKILVKQSPMLVAYDNAVNLSCKYSYNLFSREFRASLHKGLDSAVEVCVVYGNYSQQLQVYSKTGFNCDGKLGNESVTFYLQNLYVNQTDIYFCKIEVMYPPPYLDNEKSNGTIIHVKGKHLCPSPLFPGPSKPFWVLVVVGGVLACYSLLVTVAFIIFWVRSKRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRS
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency 123 with HPV-related verrucosis (IMD123) [MIM:620901]: An autosomal recessive immunologic disorder characterized by susceptibility to human papilloma virus (HPV) infections and the development of HPV-related common verrucosis in the first decade of life. In some patients with HPV2 infection, warts may progress to severe generalized hyperkeratotic cutaneous papillomatosis with cutaneous horns ('tree-man' phenotype). In patients with HPV4 infection, warts remains stable and may even regress with age. {ECO:0000269|PubMed:34214472}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis (PubMed:1650475, PubMed:7568038). Functions not only as an amplifier of TCR signals but delivers unique signals that control intracellular biochemical events that alter the gene expression program of T-cells (PubMed:24665965). Stimulation upon engagement of its cognate ligands CD80 or CD86 increases proliferation and expression of various cytokines in particular IL2 production in both CD4(+) and CD8(+) T-cell subsets (PubMed:12196291, PubMed:1650475, PubMed:35397202). Mechanistically, ligation induces recruitment of protein kinase C-theta/PRKCQ and GRB2 leading to NF-kappa-B activation via both PI3K/Akt-dependent and -independent pathways (PubMed:21964608, PubMed:24665965, PubMed:7568038). In conjunction with TCR/CD3 ligation and CD40L costimulation, enhances the production of IL4 and IL10 in T-cells (PubMed:8617933). {ECO:0000269|PubMed:12196291, ECO:0000269|PubMed:1650475, ECO:0000269|PubMed:21964608, ECO:0000269|PubMed:24665965, ECO:0000269|PubMed:35397202, ECO:0000269|PubMed:7568038, ECO:0000269|PubMed:8617933}.; FUNCTION: [Isoform 3]: Enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037). {ECO:0000269|PubMed:15067037}.
uniprot
proteins
mass_dalton
25066
uniprot
proteins
mutagenesis
MUTAGEN 160; /note="G->Y: About 75% loss of IL2 release."; /evidence="ECO:0000269|PubMed:35397202"; MUTAGEN 164; /note="A->L: About 75% loss of IL2 release."; /evidence="ECO:0000269|PubMed:35397202"; MUTAGEN 191; /note="Y->F: Greatly reduced phosphorylation by LCK."; /evidence="ECO:0000269|PubMed:7568038
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by LCK (PubMed:7568038). Dephosphorylated by PTPN11 (PubMed:36114179). {ECO:0000269|PubMed:36114179, ECO:0000269|PubMed:7568038}.; PTM: [Isoform 3]: Tyrosine phosphorylated induced by CD40LG. {ECO:0000269|PubMed:15067037}.
uniprot
proteins
pubmed
11735222
uniprot
proteins
pubmed
11877290
uniprot
proteins
pubmed
11916166
uniprot
proteins
pubmed
12196291
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15067037
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15696168
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
1650475
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
2162892
uniprot
proteins
pubmed
21964608
uniprot
proteins
pubmed
24098653
uniprot
proteins
pubmed
24665965
uniprot
proteins
pubmed
2825196
uniprot
proteins
pubmed
34214472
uniprot
proteins
pubmed
35397202
uniprot
proteins
pubmed
36114179
uniprot
proteins
pubmed
7568038
uniprot
proteins
pubmed
8617933
uniprot
proteins
sequence_length
220
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:35397202}; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Cell surface {ECO:0000269|PubMed:15067037}.
uniprot
proteins
transmembrane_region
TRANSMEM 153..179; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins