Dbf4
entrez
27214
canonical
uniprot
Q9QZ41
canonical
ensembl
ENSMUSG00000002297
resolver
ensp
ENSMUSP00000002368
resolver
ensp
ENSMUSP00000132906
resolver
genesymbol
Dbf4
resolver
genesymbol_syn
Dbf4a
resolver
uniprot
B2RS44
resolver
uniprot
B7ZNS0
resolver
uniprot
Q3TQP4
resolver
uniprot
Q3V1K2
resolver
uniprot
Q6NSQ1
resolver
uniprot
Q9CXF2
resolver
uniprot_entry
B2RS44_MOUSE
resolver
uniprot_entry
DBF4A_MOUSE
resolver
uniprot_sec
B7ZNS0
resolver
uniprot_sec
Q3TQP4
resolver
uniprot_sec
Q3V1K2
resolver
uniprot_sec
Q6NSQ1
resolver
uniprot_sec
Q9CXF2
resolver
amino_acid_sequence
MNLETMRIHSKAPLPGGIQDRNEKNRPSLKSLKADNRLEKSKYKPLWGKIFYLDLPSITICEKLQKDIKELGGRVEEFLSKDISYFVSNKKEAKYAQTLGRVSPVPSPESAYTAETTSPHPSHDGSSFKSQDRVCLSRGKLLAEKAVKDHDFIPANSILSNALSWGVKILHIDDIRYYIEQKKKALSALKKSSASGKDAGKKAGPGIQKTRTGRLKKPFLKVEDVNRCYRPFYLQLPSLPCINYFLQKPCSPFDIEKSSSVQKQAQPKLRINMDGDKCGTPVQLQLKEKRKKGYCECCLQKYEDLETHLLSEKHRNFAQSNQYQVVDDIVSQLVFDFVEYGRDTPQKKRIRYSVGSLSSVSANVLKNTAPKEKPLLEPNFQKDVGESSGHLLKPNSQYEETQKPEEKHGFASEPTTYSSAGLKGCDRKPVSMFNASEPDPEQEYAQLPLRDSTPEHQVTEGRNDGEQRVDPAPGVSQSCGQVSHLSTESNLPQPQLAADITQLSAKDLQEKGFHVVIGHASDLVALNTSKEQLTMKARTPPCSPQEPHECDTENMENLPCGKIQRKVRMLLGQQKANAEPSAELDKKRTEYLPAHEDRTCGSPVQSLLDLFQTSEEKSEFLGFTGYTENSGICDVLDIWEEENSSTLLSTFFSSPSTSAFVGF
uniprot
proteins
function
FUNCTION: Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role DNA in replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:10517317}.
uniprot
proteins
mass_dalton
74176
uniprot
proteins
post_translational_modification
PTM: Phosphorylation increases its interaction with PSIP1. {ECO:0000250|UniProtKB:Q9UBU7}.
uniprot
proteins
pubmed
10517317
uniprot
proteins
pubmed
12614612
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
663
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins