Glo1
entrez
294320
canonical
uniprot
Q6P7Q4
canonical
ensembl
ENSRNOG00055007419
resolver
ensembl
ENSRNOG00060004723
resolver
ensembl
ENSRNOG00065031125
resolver
ensp
ENSRNOP00055009807
resolver
ensp
ENSRNOP00060005937
resolver
ensp
ENSRNOP00065044109
resolver
enst
ENSRNOT00055012356
resolver
enst
ENSRNOT00060007895
resolver
enst
ENSRNOT00065053662
resolver
genesymbol
Glo1
resolver
uniprot_entry
LGUL_RAT
resolver
amino_acid_sequence
MAEPQPASSGLTDEAALSCCSDPDPSTKDFLLQQTMLRIKDPKKSLDFYTRVLGLTLLQKLDFPSMKFSLYFLAYEDKNDIPKDKTERTAWAFSRKATLELTHNWGTEDDETQSYHNGNSDPRGFGHIGIAVPDVYEACKRFEELGVKFVKKPDDGKMKGLAFVQDPDGYWIEILNPNKMATII
uniprot
proteins
ec_number
4.4.1.5
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione (PubMed:8719777). Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (By similarity). Required for normal osteoclastogenesis (By similarity). {ECO:0000250|UniProtKB:Q04760, ECO:0000250|UniProtKB:Q9CPU0, ECO:0000269|PubMed:8719777}.
uniprot
proteins
mass_dalton
20820
uniprot
proteins
pathway_participation
PATHWAY: Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.
uniprot
proteins
post_translational_modification
PTM: Glutathionylation at Cys-139 inhibits enzyme activity. {ECO:0000250|UniProtKB:Q04760}.; PTM: Phosphorylated at Thr-107 in the presence of CaMK2. However, this is a consensus site for phosphorylation by CK2 so phosphorylation may be mediated by CK2 rather than CaMK2. Phosphorylation is induced by TNF and suppresses the TNF-induced transcriptional activity of NF-kappa-B (By similarity). {ECO:0000250|UniProtKB:Q04760}.; PTM: Exists in a nitric oxide (NO)-modified form. The exact nature of the modification is unknown, but it suppresses the TNF-induced transcriptional activity of NF-kappa-B (By similarity). {ECO:0000250|UniProtKB:Q04760}.
uniprot
proteins
protein_family
Glyoxalase I family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8719777
uniprot
proteins
sequence_length
184
uniprot
proteins