Nsmce1
entrez
361645
canonical
uniprot
Q499U6
canonical
ensembl
ENSRNOG00000015218
resolver
ensp
ENSRNOP00000051912
resolver
ensp
ENSRNOP00000071768
resolver
genesymbol
Nsmce1
resolver
uniprot_entry
NSE1_RAT
resolver
amino_acid_sequence
MQGSTRRAGAMTDVHRRFLQLLMTHGVLEEWEVRRLQNHCYKVHDRNATVDKLEDFINNINSVLESLYIEIKKGITEDDGRPIYALVNLATTSVSKMATDFAENELDLFRKALELIVDSETGFASSTNILNLVDQLKGKKMRKKEAEQVLQKFVQSKWLIEKEGEFTLHGRAILEMEQFIRESYPDAVKMCNICHSLLIQGQSCETCGIRMHLPCVAKYFQSTAEPRCPHCNDYWPHDIPEVFDPEKEREAGISKSSRKSLRTRQH
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Within MAGE-RING ubiquitin ligase complex, MAGE stimulates and specifies ubiquitin ligase activity likely through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. Involved in maintenance of genome integrity, DNA damage response and DNA repair. NSMCE3/MAGEG1 and NSMCE1 ubiquitin ligase are components of SMC5-SMC6 complex and may positively regulate homologous recombination-mediated DNA repair. {ECO:0000250|UniProtKB:Q8WV22}.
uniprot
proteins
mass_dalton
30702
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. {ECO:0000250|UniProtKB:Q8WV22}.
uniprot
proteins
protein_family
NSE1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
266
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8WV22}. Chromosome, telomere {ECO:0000250|UniProtKB:Q8WV22}.
uniprot
proteins