Gpr62
entrez
436090
canonical
uniprot
Q80UC6
canonical
ensembl
ENSMUSG00000091735
resolver
ensp
ENSMUSP00000129055
resolver
enst
ENSMUST00000164834
resolver
genesymbol
Gpr62
resolver
uniprot
Q8CEQ6
resolver
uniprot_entry
GPR62_MOUSE
resolver
uniprot_sec
Q8CEQ6
resolver
amino_acid_sequence
MANGSGLSVTELAGSVGFILAVLVEVGAVLGNGTLLVVVLRTPDLQDAFYLAHLCVVDLLAAASIMPLGLLAAPPGLGTVPLDPSSCRAARFLSAALLPACTLGVAALGLARYRLIVHPLRPGARPAPALVLTAVWSAAALLGALSLLGPPPAPPPAPARCSVLAGGLGPFRPLWAMLAFALPALLLLAAYGSIFLVARRAALRPPRGTRPRSDSLDSRLSFLPPLRPRLLGGKAALAPALAVGQFAACWLPYGCACLAPAARAAAAEATVTWVAYSAFAAHPFLYGLLQRPVRLALGRLTRRALPRAPKACTSQAWHLQTLLRRLQELRKDPVLGPSEAPEQARELARQTPSVSEAT
uniprot
proteins
function
FUNCTION: Orphan G protein-coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways (PubMed:28912303). Has spontaneous activity for beta-arrestin recruitment (By similarity). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (By similarity). {ECO:0000250|UniProtKB:Q9BZJ7, ECO:0000269|PubMed:28912303}.
uniprot
proteins
mass_dalton
37148
uniprot
proteins
mutagenesis
MUTAGEN 111; /note="A->D: No effect on constitutive activity; No effect on protein level; Does not affect homooligomerization."; /evidence="ECO:0000269|PubMed:28912303"; MUTAGEN 232..237; /note="GGKAAL->KKAAKT: Strong decreases on constitutive activity; No effect on protein level; Does not affect homooligomerization."; /evidence="ECO:0000269|PubMed:28912303
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12679517
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
28912303
uniprot
proteins
sequence_length
358
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9BZJ7}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000250|UniProtKB:Q9BZJ7}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with ARRB2 in the endosome. {ECO:0000250|UniProtKB:Q9BZJ7}.
uniprot
proteins
transmembrane_region
TRANSMEM 18..38; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 54..74; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 90..110; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 129..149; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 177..197; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 235..255; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 269..289; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins