SELS
entrez
55829
canonical
uniprot
Q9BQE4
canonical
ensembl
ENSG00000131871
resolver
ensp
ENSP00000381282
resolver
ensp
ENSP00000433541
resolver
enst
ENST00000398226
resolver
enst
ENST00000526049
resolver
genesymbol
SELENOS
resolver
genesymbol
SELS
resolver
genesymbol_syn
SELS
resolver
genesymbol_syn
VIMP
resolver
hgnc
HGNC:30396
resolver
uniprot
Q3B771
resolver
uniprot
Q6GYA4
resolver
uniprot
Q9P0I6
resolver
uniprot_entry
Q6GYA4_HUMAN
resolver
uniprot_entry
SELS_HUMAN
resolver
uniprot_sec
Q3B771
resolver
uniprot_sec
Q9P0I6
resolver
amino_acid_sequence
MERQEESLSARPALETEGLRFLHTTVGSLLATYGWYIVFSCILLYVVFQKLSARLRALRQRQLDRAAAAVEPDVVVKRQEALAAARLKMQEELNAQVEKHKEKLKQLEEEKRRQKIEMWDSMQEGKSYKGNAKKPQEEDSPGPSTSSVLKRKSDRKPLRGGGYNPLSGEGGGACSWRPGRRGPSSGGUG
uniprot
proteins
function
FUNCTION: Involved in the degradation process of misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Probably acts by serving as a linker between DERL1, which mediates the retrotranslocation of misfolded proteins into the cytosol, and the ATPase complex VCP, which mediates the translocation and ubiquitination. {ECO:0000269|PubMed:15215856}.
uniprot
proteins
mass_dalton
21163
uniprot
proteins
post_translational_modification
PTM: Truncated SELENOS proteins produced by failed UGA/Sec decoding are ubiquitinated by the CRL2(KLHDC2) and CRL2(KLHDC3) complexes, which recognizes the glycine (Gly) at the C-terminus of truncated SELENOS proteins (PubMed:26138980, PubMed:30526872). Truncated SELENOS proteins produced by failed UGA/Sec decoding are also ubiquitinated by the CRL5(KLHDC1) complex (PubMed:32200094). {ECO:0000269|PubMed:26138980, ECO:0000269|PubMed:30526872, ECO:0000269|PubMed:32200094}.
uniprot
proteins
protein_family
Selenoprotein S family
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
12775843
uniprot
proteins
pubmed
15215856
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16186509
uniprot
proteins
pubmed
16186510
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21896481
uniprot
proteins
pubmed
22016385
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26138980
uniprot
proteins
pubmed
27645994
uniprot
proteins
pubmed
30526872
uniprot
proteins
pubmed
32200094
uniprot
proteins
sequence_length
189
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein. Cytoplasm {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 28..48; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins