Pmch
entrez
24659
canonical
uniprot
P14200
canonical
ensembl
ENSRNOG00000066777
resolver
ensp
ENSRNOP00000091581
resolver
enst
ENSRNOT00000095213
resolver
genesymbol
Pmch
resolver
genesymbol_syn
Mch
resolver
uniprot
A0A8I6ABX9
resolver
uniprot_entry
A0A8I6ABX9_RAT
resolver
uniprot_entry
MCH_RAT
resolver
amino_acid_sequence
MAKMSLSSYMLMLAFSLFSHGILLSASKSIRNVEDDIVFNTFRMGKAFQKEDTAERSVVAPSLEGYKNDESGFMKDDDDKTTKNTGSKQNLVTHGLPLSLAVKPYLALKGPAVFPAENGVQNTESTQEKREIGDEENSAKFPIGRRDFDMLRCMLGRVYRPCWQV
uniprot
proteins
function
FUNCTION: [Melanin-concentrating hormone]: Neuropeptide ligand for the G protein-coupled receptor MCHR1 and MCHR2 that can activate both G(i/o)- and G(q/11)-dependent signaling pathways (By similarity). Acts as a neuromodulator in the central nervous system, promoting feeding, positive energy balance (orexigenic) and sleep (PubMed:12964948, PubMed:9575823). Inhibits stimulated ACTH release (lowering plasma glucocorticoids), consistent with a role in down-regulating hypothalamic-pituitary-adrenal (HPA) axis activity (PubMed:9575823). Functionally antagonizes melanotropin alpha (alpha-MSH), opposing its inhibitory effect on food intake and exploratory behaviors and its stimulatory effect on the HPA axis (PubMed:9145426, PubMed:9575823). Antagonizes NEI-induced behavioral effects (PubMed:9145426). May also participate in spermatocyte differentiation (By similarity). {ECO:0000250|UniProtKB:P20382, ECO:0000250|UniProtKB:P56942, ECO:0000269|PubMed:12964948, ECO:0000269|PubMed:9145426, ECO:0000269|PubMed:9575823}.; FUNCTION: [Neuropeptide-glutamic acid-isoleucine]: Neuropeptide that modulates stress-related neuroendocrine responses and behaviors, increasing grooming, rearing and locomotor activity (PubMed:7647772, PubMed:9145426). Stimulates ACTH secretion, functionally counteracting the ACTH-suppressing action of MCH; the underlying mechanism is not fully characterized (PubMed:7647772). Reduces dopamine and DOPAC release in the ventromedial nucleus (PubMed:9700748). Influences differentiation of neuronal processes and affects neurofilament protein content in vitro (PubMed:9809645). {ECO:0000269|PubMed:7647772, ECO:0000269|PubMed:9145426, ECO:0000269|PubMed:9700748, ECO:0000269|PubMed:9809645}.
uniprot
proteins
mass_dalton
18482
uniprot
proteins
post_translational_modification
PTM: Pro-MCH is processed differentially in the brain and in peripheral organs producing two neuropeptides; NEI and MCH. A third peptide, NGE, may also be produced. Preferential processing in neurons by prohormone convertase 2 (PC2) generates NEI. MCH is generated in neurons of the lateral hypothalmic area by several prohormone convertases including PC1/3, PC2 and PC5/6. {ECO:0000269|PubMed:10037747, ECO:0000269|PubMed:1327720}.
uniprot
proteins
protein_family
Melanin-concentrating hormone family
uniprot
proteins
pubmed
10037747
uniprot
proteins
pubmed
12964948
uniprot
proteins
pubmed
1327720
uniprot
proteins
pubmed
2261081
uniprot
proteins
pubmed
2477226
uniprot
proteins
pubmed
2759038
uniprot
proteins
pubmed
7617126
uniprot
proteins
pubmed
7647772
uniprot
proteins
pubmed
7783849
uniprot
proteins
pubmed
8593803
uniprot
proteins
pubmed
9145426
uniprot
proteins
pubmed
9575823
uniprot
proteins
pubmed
9700748
uniprot
proteins
pubmed
9809645
uniprot
proteins
sequence_length
165
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Neuropeptide-glutamic acid-isoleucine]: Secreted {ECO:0000269|PubMed:1327720}.; SUBCELLULAR LOCATION: [Melanin-concentrating hormone]: Secreted {ECO:0000269|PubMed:1327720}.
uniprot
proteins