CMKLR1
entrez
1240
canonical
uniprot
Q99788
canonical
ensembl
ENSG00000174600
resolver
ensp
ENSP00000311733
resolver
ensp
ENSP00000401293
resolver
ensp
ENSP00000447579
resolver
ensp
ENSP00000449716
resolver
ensp
ENSP00000551113
resolver
genesymbol
CMKLR1
resolver
genesymbol_syn
CHEMR23
resolver
genesymbol_syn
DEZ
resolver
hgnc
HGNC:2121
resolver
uniprot
A8K6Y5
resolver
uniprot
O75748
resolver
uniprot
Q3KP37
resolver
uniprot
Q5U0H0
resolver
uniprot
Q99789
resolver
uniprot_entry
CML1_HUMAN
resolver
uniprot_sec
A8K6Y5
resolver
uniprot_sec
O75748
resolver
uniprot_sec
Q3KP37
resolver
uniprot_sec
Q5U0H0
resolver
uniprot_sec
Q99789
resolver
amino_acid_sequence
MRMEDEDYNTSISYGDEYPDYLDSIVVLEDLSPLEARVTRIFLVVVYSIVCFLGILGNGLVIIIATFKMKKTVNMVWFLNLAVADFLFNVFLPIHITYAAMDYHWVFGTAMCKISNFLLIHNMFTSVFLLTIISSDRCISVLLPVWSQNHRSVRLAYMACMVIWVLAFFLSSPSLVFRDTANLHGKISCFNNFSLSTPGSSSWPTHSQMDPVGYSRHMVVTVTRFLCGFLVPVLIITACYLTIVCKLQRNRLAKTKKPFKIIVTIIITFFLCWCPYHTLNLLELHHTAMPGSVFSLGLPLATALAIANSCMNPILYVFMGQDFKKFKVALFSRLVNALSEDTGHSSYPSHRSFTKMSSMNERTSMNERETGML
uniprot
proteins
function
FUNCTION: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2), TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis (PubMed:27716822). Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. {ECO:0000269|PubMed:15728234, ECO:0000269|PubMed:15753205, ECO:0000269|PubMed:20044979, ECO:0000269|PubMed:27716822}.; FUNCTION: (Microbial infection) Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). {ECO:0000269|PubMed:9603476}.
uniprot
proteins
mass_dalton
42322
uniprot
proteins
protein_family
Chemokine-like receptor (CMKLR) family
uniprot
proteins
pubmed
14530373
uniprot
proteins
pubmed
14675762
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14759258
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15728234
uniprot
proteins
pubmed
15753205
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
16863918
uniprot
proteins
pubmed
18242188
uniprot
proteins
pubmed
20044979
uniprot
proteins
pubmed
27716822
uniprot
proteins
pubmed
29279348
uniprot
proteins
pubmed
8976386
uniprot
proteins
pubmed
9144535
uniprot
proteins
pubmed
9603476
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15728234, ECO:0000269|PubMed:16863918, ECO:0000269|PubMed:27716822}; Multi-pass membrane protein {ECO:0000255}. Note=Internalizes efficiently in response to RARRES2. {ECO:0000269|PubMed:27716822}.
uniprot
proteins
transmembrane_region
TRANSMEM 42..64; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 76..97; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 115..135; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 155..176; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 225..245; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 262..282; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 301..320; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins