CDCA5
entrez
113130
canonical
uniprot
Q96FF9
canonical
ensembl
ENSG00000146670
resolver
ensp
ENSP00000275517
resolver
enst
ENST00000275517
resolver
genesymbol
CDCA5
resolver
hgnc
HGNC:14626
resolver
uniprot
A8K625
resolver
uniprot_entry
CDCA5_HUMAN
resolver
uniprot_sec
A8K625
resolver
amino_acid_sequence
MSGRRTRSGGAAQRSGPRAPSPTKPLRRSQRKSGSELPSILPEIWPKTPSAAAVRKPIVLKRIVAHAVEVPAVQSPRRSPRISFFLEKENEPPGRELTKEDLFKTHSVPATPTSTPVPNPEAESSSKEGELDARDLEMSKKVRRSYSRLETLGSASTSTPGRRSCFGFEGLLGAEDLSGVSPVVCSKLTEVPRVCAKPWAPDMTLPGISPPPEKQKRKKKKMPEILKTELDEWAAAMNAEFEAAEQFDLLVE
uniprot
proteins
function
FUNCTION: Regulator of sister chromatid cohesion in mitosis, stabilizing cohesin complex association with chromatin. May antagonize the action of WAPL which stimulates cohesin dissociation from chromatin. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair. Required for efficient DNA double-stranded break repair. {ECO:0000269|PubMed:15837422, ECO:0000269|PubMed:17349791, ECO:0000269|PubMed:21111234, ECO:0000269|PubMed:41261216}.
uniprot
proteins
mass_dalton
27601
uniprot
proteins
mutagenesis
MUTAGEN 166..168; /note="FGF->AGA: Alters interaction with PDS5A and PDS5B and the cohesin complex."; /evidence="ECO:0000269|PubMed:21111234
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation, as cells enter mitosis, disrupts the interaction with PDS5A and relieves the inhibition of WAPL by CDCA5. {ECO:0000269|PubMed:15837422}.; PTM: Ubiquitinated by the APC/C complex in G1, leading to its degradation. {ECO:0000305|PubMed:15837422}.
uniprot
proteins
protein_family
Sororin family
uniprot
proteins
pubmed
12188893
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15837422
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17349791
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21111234
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
41261216
uniprot
proteins
sequence_length
252
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15837422, ECO:0000269|PubMed:41261216}. Chromosome {ECO:0000269|PubMed:15837422}. Cytoplasm {ECO:0000269|PubMed:15837422}. Note=Associates with nuclear chromatin from S phase until metaphase and is released in the cytoplasm upon nuclear envelope breakdown.
uniprot
proteins