Slc8a1
entrez
29715
canonical
uniprot
Q01728
canonical
ensembl
ENSRNOG00000008479
resolver
ensp
ENSRNOP00000040765
resolver
ensp
ENSRNOP00000043539
resolver
ensp
ENSRNOP00000044094
resolver
ensp
ENSRNOP00000050918
resolver
ensp
ENSRNOP00000077184
resolver
ensp
ENSRNOP00000082575
resolver
ensp
ENSRNOP00000093763
resolver
enst
ENSRNOT00000042251
resolver
enst
ENSRNOT00000043870
resolver
enst
ENSRNOT00000101103
resolver
genesymbol
Slc8a1
resolver
genesymbol_syn
Ncx1
resolver
uniprot
A0A8I6AXH4
resolver
uniprot
A0A8L2QK59
resolver
uniprot
A0A8L2QNY8
resolver
uniprot
Q924Y2
resolver
uniprot
Q9QW49
resolver
uniprot
Q9R238
resolver
uniprot
Q9R239
resolver
uniprot
Q9WU29
resolver
uniprot
Q9WU30
resolver
uniprot_entry
A0A8I6AXH4_RAT
resolver
uniprot_entry
A0A8L2QK59_RAT
resolver
uniprot_entry
A0A8L2QNY8_RAT
resolver
uniprot_entry
NAC1_RAT
resolver
uniprot_sec
Q924Y2
resolver
uniprot_sec
Q9QW49
resolver
uniprot_sec
Q9R238
resolver
uniprot_sec
Q9R239
resolver
uniprot_sec
Q9WU29
resolver
uniprot_sec
Q9WU30
resolver
activity_regulation
ACTIVITY REGULATION: Activated by micromolar levels of Ca(2+) (PubMed:12502557). {ECO:0000269|PubMed:12502557}.; ACTIVITY REGULATION: [Isoform 4]: Only active at low calcium concentrations (PubMed:15040000). Not activated by PKC (PubMed:15040000). {ECO:0000269|PubMed:15040000}.; ACTIVITY REGULATION: [Isoform 5]: Active at all calcium levels tested (PubMed:15040000). Activated by PKC (PubMed:15040000). {ECO:0000269|PubMed:15040000}.; ACTIVITY REGULATION: [Isoform 6]: Only active at low calcium concentrations (PubMed:15040000). Activated by PKC (PubMed:15040000). {ECO:0000269|PubMed:15040000}.
uniprot
proteins
amino_acid_sequence
MLRLSLPPNVSMGFRLVTLVALLFTHVDHITADTEAETGGNETTECTGSYYCKKGVILPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVSSPGVVEVWEGLLTFFFFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPASKTEIEMDGKVVNSHVDNFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKSRAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNMDVVENDPVSKVFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVIFKPGETQKEIRVGIIDDDIFEEDENFLVHLSNVRVSSEVSEDGILDSNHVSAIACLGSPNTATITIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIIPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFIEIGEPRLVEMSEKKALLLNELGGFTLTEGKKMYGQPVFRKVHARDHPIPSTVISISEEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSSLFVLLWLLYIFFSSLEAYCHIKGF
uniprot
proteins
function
FUNCTION: Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:10894800, PubMed:12502557, PubMed:8422940, PubMed:8454039). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions (By similarity). {ECO:0000250|UniProtKB:P70414, ECO:0000269|PubMed:10894800, ECO:0000269|PubMed:12502557, ECO:0000269|PubMed:15040000, ECO:0000269|PubMed:8422940, ECO:0000269|PubMed:8454039}.
uniprot
proteins
mass_dalton
108185
uniprot
proteins
protein_family
Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family
uniprot
proteins
protein_family
SLC8 subfamily
uniprot
proteins
pubmed
10894800
uniprot
proteins
pubmed
12502557
uniprot
proteins
pubmed
1415740
uniprot
proteins
pubmed
15040000
uniprot
proteins
pubmed
16914199
uniprot
proteins
pubmed
23506867
uniprot
proteins
pubmed
8195112
uniprot
proteins
pubmed
8255180
uniprot
proteins
pubmed
8276763
uniprot
proteins
pubmed
8422940
uniprot
proteins
pubmed
8454039
uniprot
proteins
pubmed
8798769
uniprot
proteins
sequence_length
971
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10894800, ECO:0000269|PubMed:12502557, ECO:0000269|PubMed:16914199, ECO:0000269|PubMed:8422940}; Multi-pass membrane protein {ECO:0000305}. Cell projection, dendrite {ECO:0000269|PubMed:16914199}.
uniprot
proteins
transmembrane_region
TRANSMEM 72..92; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 134..154; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 168..188; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 202..222; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 229..249; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 799..819; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 823..843; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 873..893; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 905..925; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 943..963; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins