Oga
entrez
154968
canonical
uniprot
Q8VIJ5
canonical
ensembl
ENSRNOG00000017822
resolver
ensembl
ENSRNOG00060023694
resolver
ensembl
ENSRNOG00065029612
resolver
ensp
ENSRNOP00000059568
resolver
ensp
ENSRNOP00000088821
resolver
ensp
ENSRNOP00000112378
resolver
enst
ENSRNOT00000065172
resolver
enst
ENSRNOT00000109554
resolver
genesymbol
Oga
resolver
genesymbol_syn
Hexc
resolver
genesymbol_syn
Mea5
resolver
genesymbol_syn
Mgea5
resolver
uniprot
A0A0H2UI10
resolver
uniprot
A0A8I6AAH5
resolver
uniprot_entry
A0A0H2UI10_RAT
resolver
uniprot_entry
A0A8I6AAH5_RAT
resolver
uniprot_entry
OGA_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by Cu(2+), Hg(2+), Cd(2+) and Zn(2+) at 1 mM. Not inhibited by Co(2+), Mg(2+), Ca(2+), Mn(2+), Fe(3+) and EDTA. Also inhibited by sodium chloride at 1M and 2-amino-2-hydroxymethyl-1,3-propanediol (trishydroxymethylaminomethane) at 75 mM. {ECO:0000269|PubMed:8034696}.
uniprot
proteins
amino_acid_sequence
MVQKESQAALEERESERNANPASVSGASLEPSAAPAPGEDNPSGAGAAAGTGAAGGARRFLCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHNMCAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPSVSQSPYLRTVGEKLLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRSTELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRKDVVMTDSEDSTVSIQIKLENEGSDEDIETDVLYSPQMALKLALTEWLQEFGVPHQYSSRQVAHSGAKTSVVDGTPLVAAPSLNATTVVTTVYQEPIMSQGAALSGEPSALTKEEEKKQPDEEPMDMVVEKQEESEHKSDNQILTEIVEAKMAEELKPMDTDKESIAESKSPEMSMQEDCINDIAPMQTDEQANKEQFVPGPNEKPLYAAEPVTLEDLQLLADLFYLPYEHGPKGAQMLREFQWLRANSSVVSVNCKGKDSEKIEEWRSRAAKFEEMCALVMGMFTRLSNCANRTILYDMYSYVWDIKSIMSMVKSFVQWLGCRSHSSAQFLIGDQEPWAFRGGLAGEFQRLLPIDGANDLFFQPPPLTPTSKVYTIRPYFPKDEASVYKICREMYDDGVGLPFQSQPDLIGDKLVGGLLSLSLDYCFVLEDEDGICGYALGTVDVTPFIKKCKISWIPFMQEKYTKPNGDKELSEAEKIMLSFHEEQEVLPETFLANFPSLIKMDIHKKVTDPSVAKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIAKMEGFPKDVVILGRSL
uniprot
proteins
ec_number
3.2.1.169
uniprot
proteins
function
FUNCTION: [Isoform 1]: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins (PubMed:8034696). Deglycosylates a large and diverse number of proteins, such as CRYAB, ELK1, GSDMD, LMNB1 and TAB1 (By similarity). Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:8034696). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (By similarity). {ECO:0000250|UniProtKB:O60502, ECO:0000269|PubMed:8034696}.; FUNCTION: [Isoform 2]: Lacks enzyme activity. {ECO:0000269|PubMed:16517082}.; FUNCTION: [Isoform 3]: Lacks enzyme activity. {ECO:0000269|PubMed:16517082}.
uniprot
proteins
mass_dalton
102918
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved by caspase-3 during apoptosis. The fragments interact with each other; cleavage does not decrease enzyme activity. {ECO:0000250|UniProtKB:O60502}.
uniprot
proteins
protein_family
Glycosyl hydrolase 84 family
uniprot
proteins
pubmed
15485860
uniprot
proteins
pubmed
16517082
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8034696
uniprot
proteins
sequence_length
916
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8034696}. Cytoplasm {ECO:0000269|PubMed:8034696}.
uniprot
proteins