Ptgds
entrez
19215
canonical
uniprot
O09114
canonical
ensembl
ENSMUSG00000015090
resolver
ensp
ENSMUSP00000015234
resolver
ensp
ENSMUSP00000109889
resolver
ensp
ENSMUSP00000109897
resolver
ensp
ENSMUSP00000226191
resolver
genesymbol
Ptgds
resolver
uniprot
O09157
resolver
uniprot
O35091
resolver
uniprot
Q3V2G5
resolver
uniprot
Q62169
resolver
uniprot_entry
PTGDS_MOUSE
resolver
uniprot_sec
O09157
resolver
uniprot_sec
O35091
resolver
uniprot_sec
Q3V2G5
resolver
uniprot_sec
Q62169
resolver
amino_acid_sequence
MAALRMLWMGLVLLGLLGFPQTPAQGHDTVQPNFQQDKFLGRWYSAGLASNSSWFREKKAVLYMCKTVVAPSTEGGLNLTSTFLRKNQCETKIMVLQPAGAPGHYTYSSPHSGSIHSVSVVEANYDEYALLFSRGTKGPGQDFRMATLYSRTQTLKDELKEKFTTFSKAQGLTEEDIVFLPQPDKCIQE
uniprot
proteins
ec_number
5.3.99.2
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophobic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system (PubMed:10781097, PubMed:11751991, PubMed:12077186, PubMed:17715133, PubMed:19546224, PubMed:19833210, PubMed:8922532, PubMed:9892701). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (PubMed:23624557). Can also, catalyze the conversion of PGH3 (derived from eicosapentaenoate (EPA, C20:5n-3)) to PGD3, though PGH2 remains the preferred substrate (By similarity). {ECO:0000250|UniProtKB:P41222, ECO:0000269|PubMed:10781097, ECO:0000269|PubMed:11751991, ECO:0000269|PubMed:12077186, ECO:0000269|PubMed:17715133, ECO:0000269|PubMed:19546224, ECO:0000269|PubMed:19833210, ECO:0000269|PubMed:23624557, ECO:0000269|PubMed:8922532, ECO:0000269|PubMed:9892701}.
uniprot
proteins
mass_dalton
21066
uniprot
proteins
mutagenesis
MUTAGEN 45; /note="S->A: Reduces enzyme activity by about half. Reduces enzyme activity tenfold; when associated with A-67 and A-81."; /evidence="ECO:0000269|PubMed:19546224"; MUTAGEN 65; /note="C->A: Loss of enzyme activity. No effect on ligand binding."; /evidence="ECO:0000269|PubMed:19546224"; MUTAGEN 67; /note="T->A: Reduces enzyme activity by about half. Reduces enzyme activity tenfold; when associated with A-45 and A-81."; /evidence="ECO:0000269|PubMed:19546224"; MUTAGEN 81; /note="S->A: Slightly reduced enzyme activity. half. Reduces enzyme activity tenfold; when associated with A-45 and A-67."; /evidence="ECO:0000269|PubMed:19546224
uniprot
proteins
protein_family
Calycin superfamily
uniprot
proteins
protein_family
Lipocalin family
uniprot
proteins
pubmed
10781097
uniprot
proteins
pubmed
10899920
uniprot
proteins
pubmed
11105911
uniprot
proteins
pubmed
11751991
uniprot
proteins
pubmed
12077186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17715133
uniprot
proteins
pubmed
19546224
uniprot
proteins
pubmed
19833210
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23624557
uniprot
proteins
pubmed
8922532
uniprot
proteins
pubmed
9892701
uniprot
proteins
sequence_length
189
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Rough endoplasmic reticulum {ECO:0000250|UniProtKB:P41222}. Nucleus membrane {ECO:0000250|UniProtKB:P41222}. Golgi apparatus {ECO:0000250|UniProtKB:P41222}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P41222}. Secreted {ECO:0000250|UniProtKB:P41222}. Note=Detected on rough endoplasmic reticulum of arachnoid and menigioma cells. Localized to the nuclear envelope, Golgi apparatus, secretory vesicles and spherical cytoplasmic structures in arachnoid trabecular cells, and to circular cytoplasmic structures in meningeal macrophages and perivascular microglial cells. In oligodendrocytes, localized to the rough endoplasmic reticulum and nuclear envelope. In retinal pigment epithelial cells, localized to distinct cytoplasmic domains including the perinuclear region. Also secreted. {ECO:0000250|UniProtKB:P41222}.
uniprot
proteins