SIX2
entrez
10736
canonical
uniprot
Q9NPC8
canonical
ensembl
ENSG00000170577
resolver
ensp
ENSP00000304502
resolver
ensp
ENSP00000603310
resolver
enst
ENST00000303077
resolver
genesymbol
SIX2
resolver
hgnc
HGNC:10888
resolver
uniprot
Q8TBA2
resolver
uniprot
Q9BXH7
resolver
uniprot_entry
Q8TBA2_HUMAN
resolver
uniprot_entry
SIX2_HUMAN
resolver
uniprot_sec
Q9BXH7
resolver
amino_acid_sequence
MSMLPTFGFTQEQVACVCEVLQQGGNIERLGRFLWSLPACEHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHAKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRSVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENNENSNSNSHNPLNGSGKSVLGSSEDEKTPSGTPDHSSSSPALLLSPPPPGLPSLHSLGHPPGPSAVPVPVPGGGGADPLQHHHGLQDSILNPMSANLVDLGS
uniprot
proteins
function
FUNCTION: Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation. During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1. During branchial arch development, acts to mediate HOXA2 control over the insulin-like growth factor pathway. May also be involved in limb tendon and ligament development (By similarity). Plays a role in cell proliferation and migration. {ECO:0000250|UniProtKB:Q62232, ECO:0000269|PubMed:22995329}.
uniprot
proteins
mass_dalton
32286
uniprot
proteins
protein_family
SIX/Sine oculis homeobox family
uniprot
proteins
pubmed
10677303
uniprot
proteins
pubmed
10773454
uniprot
proteins
pubmed
18305125
uniprot
proteins
pubmed
20515681
uniprot
proteins
pubmed
22703800
uniprot
proteins
pubmed
22995329
uniprot
proteins
sequence_length
291
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q62232}.
uniprot
proteins