HEXD
entrez
284004
canonical
uniprot
Q8WVB3
canonical
ensembl
ENSG00000169660
resolver
ensp
ENSP00000332634
resolver
ensp
ENSP00000337854
resolver
ensp
ENSP00000521825
resolver
ensp
ENSP00000665098
resolver
ensp
ENSP00000681743
resolver
genesymbol
HEXD
resolver
genesymbol_syn
HEXDC
resolver
hgnc
HGNC:26307
resolver
uniprot
B7UUP6
resolver
uniprot
Q8IYN4
resolver
uniprot
Q8TE81
resolver
uniprot_entry
HEXD_HUMAN
resolver
uniprot_sec
B7UUP6
resolver
uniprot_sec
Q8IYN4
resolver
uniprot_sec
Q8TE81
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenylcarbamate (PUGNAc) (By similarity). Inhibited by galacto-NAG-thiazoline (PubMed:27149221). {ECO:0000250|UniProtKB:Q3U4H6, ECO:0000269|PubMed:27149221}.
uniprot
proteins
amino_acid_sequence
MSGSTPFQMRLVHLDLKGAPPKVSYLSEIFPLFRALGANGLLIEYEDMFPYEGPLRLLRAKYAYSPSEIKEILHLAGLNELEVIPLVQTFGHMEFVLKHTAFAHLREVGSFPCTLNPHEAESLALVGAMIDQVLELHPGAQRLHIGCDEVYYLGEGEASRRWLQQEQNSTGKLCLSHMRAVASGVKARRPSVTPLVWDDMLRDLPEDQLAASGVPQLVEPVLWDYTADLDVHGKVLLMQKYRRCGFPQLWAASAFKGATGPSQAVPPVEHHLRNHVQWLQVAGSGPTDSLQGIILTGWQRYDHYSVLCELLPAGVPSLAACLQLLLRGGFDEDVKAKVENLLGISSLEKTDPVREGAGSFPGSNILALVTQVSLHLRSSVDALLEGNRYVTGWFSPYHRQRKLIHPVMVQHIQPAALSLLAQWSTLVQELEAALQLAFYPDAVEEWLEENVHPSLQRLQALLQDLSEVSAPPLPPTSPGRDVAQDP
uniprot
proteins
ec_number
3.2.1.52
uniprot
proteins
function
FUNCTION: Has hexosaminidase activity. Responsible for the cleavage of the monosaccharides N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) from cellular substrates. Has a preference for galactosaminide over glucosaminide substrates (PubMed:27149221). {ECO:0000269|PubMed:19040401, ECO:0000269|PubMed:23099419, ECO:0000269|PubMed:27149221}.
uniprot
proteins
mass_dalton
53790
uniprot
proteins
mutagenesis
MUTAGEN 92; /note="H->A: Decreases hexosaminidase activity."; /evidence="ECO:0000269|PubMed:27149221"; MUTAGEN 148; /note="D->A,N: Loss of hexosaminidase activity."; /evidence="ECO:0000269|PubMed:27149221"; MUTAGEN 149; /note="E->A,N: Decreases hexosaminidase activity. Optimum pH shifts to 7.5."; /evidence="ECO:0000269|PubMed:27149221
uniprot
proteins
protein_family
Glycosyl hydrolase 20 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
19040401
uniprot
proteins
pubmed
23099419
uniprot
proteins
pubmed
27149221
uniprot
proteins
sequence_length
486
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q3U4H6}. Nucleus {ECO:0000250|UniProtKB:Q3U4H6}. Extracellular vesicle {ECO:0000269|PubMed:23099419}.
uniprot
proteins