ITPKC
entrez
80271
canonical
uniprot
Q96DU7
canonical
ensembl
ENSG00000086544
resolver
ensp
ENSP00000263370
resolver
ensp
ENSP00000514400
resolver
ensp
ENSP00000514401
resolver
ensp
ENSP00000694264
resolver
ensp
ENSP00000798416
resolver
enst
ENST00000263370
resolver
enst
ENST00000699489
resolver
enst
ENST00000699490
resolver
genesymbol
ITPKC
resolver
genesymbol_syn
IP3KC
resolver
hgnc
HGNC:14897
resolver
uniprot
A0A8V8TPP3
resolver
uniprot
Q9UE25
resolver
uniprot
Q9Y475
resolver
uniprot_entry
A0A8V8TPP3_HUMAN
resolver
uniprot_entry
IP3KC_HUMAN
resolver
uniprot_sec
Q9UE25
resolver
uniprot_sec
Q9Y475
resolver
activity_regulation
ACTIVITY REGULATION: Activated by calcium/calmodulin (PubMed:12747803). Inhibited by high concentrations of the substrate Ins(1,2,4)P3, and allosterically activated by the product Ins(1,3,4,5)P4. {ECO:0000269|PubMed:11085927, ECO:0000269|PubMed:12747803}.
uniprot
proteins
amino_acid_sequence
MRRCPCRGSLNEAEAGALPAAARMGLEAPRGGRRRQPGQQRPGPGAGAPAGRPEGGGPWARTEGSSLHSEPERAGLGPAPGTESPQAEFWTDGQTEPAAAGLGVETERPKQKTEPDRSSLRTHLEWSWSELETTCLWTETGTDGLWTDPHRSDLQFQPEEASPWTQPGVHGPWTELETHGSQTQPERVKSWADNLWTHQNSSSLQTHPEGACPSKEPSADGSWKELYTDGSRTQQDIEGPWTEPYTDGSQKKQDTEAARKQPGTGGFQIQQDTDGSWTQPSTDGSQTAPGTDCLLGEPEDGPLEEPEPGELLTHLYSHLKCSPLCPVPRLIITPETPEPEAQPVGPPSRVEGGSGGFSSASSFDESEDDVVAGGGGASDPEDRSGSKPWKKLKTVLKYSPFVVSFRKHYPWVQLSGHAGNFQAGEDGRILKRFCQCEQRSLEQLMKDPLRPFVPAYYGMVLQDGQTFNQMEDLLADFEGPSIMDCKMGSRTYLEEELVKARERPRPRKDMYEKMVAVDPGAPTPEEHAQGAVTKPRYMQWRETMSSTSTLGFRIEGIKKADGTCNTNFKKTQALEQVTKVLEDFVDGDHVILQKYVACLEELREALEISPFFKTHEVVGSSLLFVHDHTGLAKVWMIDFGKTVALPDHQTLSHRLPWAEGNREDGYLWGLDNMICLLQGLAQS
uniprot
proteins
ec_number
2.7.1.127
uniprot
proteins
function
FUNCTION: Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis (PubMed:11085927, PubMed:12747803). Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate (By similarity). {ECO:0000250|UniProtKB:Q80ZG2, ECO:0000269|PubMed:11085927, ECO:0000269|PubMed:12747803}.
uniprot
proteins
mass_dalton
75207
uniprot
proteins
mutagenesis
MUTAGEN 486; /note="K->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:12747803
uniprot
proteins
protein_family
Inositol phosphokinase (IPK) family
uniprot
proteins
pubmed
11085927
uniprot
proteins
pubmed
12747803
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
683
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12747803}. Cytoplasm {ECO:0000269|PubMed:12747803}. Note=Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity. {ECO:0000250|UniProtKB:Q80ZG2}.
uniprot
proteins