Htr5a
entrez
15563
canonical
uniprot
P30966
canonical
ensembl
ENSMUSG00000039106
resolver
ensp
ENSMUSP00000038884
resolver
enst
ENSMUST00000036227
resolver
genesymbol
Htr5a
resolver
genesymbol_syn
5ht5a
resolver
uniprot
Q3URB0
resolver
uniprot
Q3UVG4
resolver
uniprot_entry
5HT5A_MOUSE
resolver
uniprot_entry
Q3UVG4_MOUSE
resolver
uniprot_sec
Q3URB0
resolver
amino_acid_sequence
MDLPVNLTSFSLSTPSSLEPNRSLDTEVLRPSRPFLSAFRVLVLTLLGFLAAATFTWNLLVLATILKVRTFHRVPHNLVASMAISDVLVAVLVMPLSLVHELSGRRWQLGRRLCQLWIACDVLCCTASIWNVTAIALDRYWSITRHLEYTLRTRKRVSNVMILLTWALSTVISLAPLLFGWGETYSEPSEECQVSREPSYTVFSTVGAFYLPLCVVLFVYWKIYRAAKFRMGSRKTNSVSPVPEAVEVKNATQHPQMVFTVRHATVTFQTEGDTWREQKEQRAALMVGILIGVFVLCWFPFFVTELISPLCSWDVPAIWKSIFLWLGYSNSFFNPLIYTAFNRSYSSAFKVFFSKQQ
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:8450829). Also functions as a receptor for ergot alkaloid derivatives and other psychoactive substances (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). Htr5a is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (By similarity). {ECO:0000250|UniProtKB:P47898, ECO:0000269|PubMed:8450829}.
uniprot
proteins
mass_dalton
40736
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10197537
uniprot
proteins
pubmed
1464308
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
8450829
uniprot
proteins
sequence_length
357
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P47898}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 37..63; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P47898"; TRANSMEM 77..103; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P47898"; TRANSMEM 115..137; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P47898"; TRANSMEM 156..176; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P47898"; TRANSMEM 199..220; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P47898"; TRANSMEM 288..312; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P47898"; TRANSMEM 315..339; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P47898
uniprot
proteins