Dok7
entrez
231134
canonical
uniprot
Q18PE0
canonical
ensembl
ENSMUSG00000044716
resolver
ensp
ENSMUSP00000059538
resolver
ensp
ENSMUSP00000098856
resolver
ensp
ENSMUSP00000109909
resolver
ensp
ENSMUSP00000316571
resolver
enst
ENSMUST00000050709
resolver
genesymbol
Dok7
resolver
uniprot
A0A0R4J0R2
resolver
uniprot
Q3TCZ6
resolver
uniprot
Q5FW70
resolver
uniprot
Q8C8U7
resolver
uniprot_entry
A0A0R4J0R2_MOUSE
resolver
uniprot_entry
DOK7_MOUSE
resolver
uniprot_sec
Q3TCZ6
resolver
uniprot_sec
Q5FW70
resolver
uniprot_sec
Q8C8U7
resolver
amino_acid_sequence
MTEAALVEGQVKLRDGKKWKSRWLVLRKPSPVADCLLMLVYKDKCERSKGLRERSSLTLEDICGLEPALPYEGLAHTLAIICLSQAVMLGFDSHEAMCAWDTRIRYALGEVHRFHVTVAPGTKLESGPATLHLCNDILVLARDIPPTVMGQWKLSDLRRYGAVPNGFIFEGGTRCGYWAGVFFLSSAEGEQMSFLFDCIVRGISPTKGPFGLRPVLPDPSSGGPSASEERVAQEALEALQLEKRLSLLSHSGRPGSGGDDRSLSSSSSEASHSDISASSRLTAWPEQSSSSAGTSQEGPGLVAAQGPGEAMLGASRPPLKPLRPRQLQEVGRQSSSDSGIATGSHSSYSGSFSSYAGSNLDVWRAGEEFGSLLSLPPGASAPEPRLCACPPGAAEYQVPTSLRHHYDTPRSLRQAPRDPSPASQGSSDHGSATDLGGQAPTGCPSSWLGARRRGQATEGPGSDAALPSPSPGESWEAGSPHAGPPPAFFLSCSICGGLKVKPPP
uniprot
proteins
function
FUNCTION: Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK. {ECO:0000269|PubMed:16794080, ECO:0000269|PubMed:20603078}.
uniprot
proteins
mass_dalton
53177
uniprot
proteins
mutagenesis
MUTAGEN 158..159; /note="RR->AA: Abolishes interaction with MUSK and function; when associated with A-174."; /evidence="ECO:0000269|PubMed:16794080"; MUTAGEN 174; /note="R->A: Abolishes interaction with MUSK and function; when associated with A-158 and A-159."; /evidence="ECO:0000269|PubMed:16794080
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16794080
uniprot
proteins
pubmed
20603078
uniprot
proteins
sequence_length
504
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16794080}; Peripheral membrane protein {ECO:0000269|PubMed:16794080}. Synapse {ECO:0000269|PubMed:16794080}. Note=Accumulates at neuromuscular junctions.
uniprot
proteins