Orai2
entrez
269717
canonical
uniprot
Q8BH10
canonical
ensembl
ENSMUSG00000039747
resolver
ensp
ENSMUSP00000037137
resolver
ensp
ENSMUSP00000142597
resolver
ensp
ENSMUSP00000228039
resolver
ensp
ENSMUSP00000228040
resolver
enst
ENSMUST00000041048
resolver
enst
ENSMUST00000196454
resolver
genesymbol
Orai2
resolver
genesymbol_syn
Tmem142b
resolver
uniprot
A0A0G2JE20
resolver
uniprot
A5CVE1
resolver
uniprot
Q14BR6
resolver
uniprot
Q8C953
resolver
uniprot_entry
A0A0G2JE20_MOUSE
resolver
uniprot_entry
A5CVE1_MOUSE
resolver
uniprot_entry
ORAI2_MOUSE
resolver
uniprot_entry
Q14BR6_MOUSE
resolver
uniprot_sec
Q8C953
resolver
activity_regulation
ACTIVITY REGULATION: CRAC channels are regulated by fast Ca(2+)-dependent inactivation (FCDI), a mechanism that limits Ca(2+) influx and cell toxicity. ORAI2 channels display prominent FCDI. Inhibited by lanthanides such as Gd(3+) ions. {ECO:0000250|UniProtKB:Q96SN7}.
uniprot
proteins
amino_acid_sequence
MSAELNVPMDPSAPACPEPGHKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETKYQYPQPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDAKDQPGSHSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKLKVQLDGHERSLQVV
uniprot
proteins
function
FUNCTION: Pore-forming subunit of inward rectifying Ca(2+) release-activated Ca(2+) (CRAC) channels. Assembles with ORAI1 and ORAI3 to form hexameric CRAC channels that mediate Ca(2+) influx upon depletion of endoplasmic reticulum Ca(2+) store and channel activation by Ca(2+) sensor STIM1, a process known as store-operated Ca(2+) entry (SOCE). Various pore subunit combinations may account for distinct CRAC channel spatiotemporal and cell-type specific dynamics. ORAI1 mainly contributes to the generation of Ca(2+) plateaus involved in sustained Ca(2+) entry and is dispensable for cytosolic Ca(2+) oscillations, whereas ORAI2 and ORAI3 generate oscillatory patterns. CRAC channels assemble in Ca(2+) signaling microdomains where Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT transcription factors recruited to ORAI1 via AKAP5. CRAC channels are the main pathway for Ca(2+) influx in T cells and promote the immune response to pathogens by activating NFAT-dependent cytokine and chemokine transcription. {ECO:0000250|UniProtKB:Q96SN7}.
uniprot
proteins
mass_dalton
28199
uniprot
proteins
protein_family
Orai family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
250
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q96SN7}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with STIM1 upon store depletion. {ECO:0000250|UniProtKB:Q96SN7}.
uniprot
proteins
transmembrane_region
TRANSMEM 66..83; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 94..114; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 148..168; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 192..212; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins