Preb
entrez
50907
canonical
uniprot
Q9WUQ2
canonical
ensembl
ENSMUSG00000045302
resolver
ensp
ENSMUSP00000074387
resolver
ensp
ENSMUSP00000144263
resolver
ensp
ENSMUSP00000215341
resolver
ensp
ENSMUSP00000215348
resolver
ensp
ENSMUSP00000215349
resolver
ensp
ENSMUSP00000215354
resolver
enst
ENSMUST00000074840
resolver
enst
ENSMUST00000202567
resolver
genesymbol
Preb
resolver
genesymbol_syn
Sec12
resolver
uniprot
D3Z3S1
resolver
uniprot
Q3UAP1
resolver
uniprot
Q9QZ99
resolver
uniprot_entry
D3Z3S1_MOUSE
resolver
uniprot_entry
Q3UAP1_MOUSE
resolver
uniprot_entry
SEC12_MOUSE
resolver
uniprot_sec
Q9QZ99
resolver
amino_acid_sequence
MGRRRGVELYRAPFPLYALRIDPKTGLLIAAGGGGAAKTGIKNGVHFLQLELINGCLSASLLHSHDTETRATMNLALAGDILAAGQDAQCQLLRFQVHQQKGSKAEKSGSKEQGPRQRKGAPPAEKKSGAQVHPEGVELKVKNLEAVQTDFSNEPLQKVVCFNHDNTLLATGGTDGHVRVWKVPSLEKVLEFKAHEGEIGDLTLGPDGKLVTVGWDFKASVWQKDQLVTQLQWQENGPASSNTPYRYQACRFGQVPDQLGGLRLFTVQIPHKRLRQPPPCYLTAWDSSTFLPLRTRSCGHEVISCLSVSDSGTFLGLGTVTGSVAIYIAFSLQRLYYVKEAHGIVVTDVTFLPEKGCGPKLLGPHETALFSVAVDSRCQLHLLPSRRSVPVWLLLLLCVGLIIVTILLLQTAFPGFL
uniprot
proteins
function
FUNCTION: Guanine nucleotide exchange factor (GEF) that regulates the assembly of the coat protein complex II/COPII in endoplasmic reticulum (ER) to Golgi vesicle-mediated transport. Selectively activates SAR1A and SAR1B by promoting the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP) in these small GTPases (PubMed:11422940). In their activated GTP-bound state, SAR1A and SAR1B insert into the membrane of the endoplasmic reticulum where they recruit the remainder of the coat protein complex II/COPII which is responsible for both the sorting of proteins and the deformation and budding of membranes into vesicles destined to the Golgi (By similarity). {ECO:0000250|UniProtKB:Q9HCU5, ECO:0000269|PubMed:11422940}.; FUNCTION: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription. {ECO:0000250|UniProtKB:Q9WTV0}.
uniprot
proteins
mass_dalton
45437
uniprot
proteins
pubmed
10704286
uniprot
proteins
pubmed
11422940
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16800626
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30858281
uniprot
proteins
sequence_length
417
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9WTV0}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9WTV0}. Nucleus {ECO:0000250|UniProtKB:Q9WTV0}. Note=Concentrates at endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). {ECO:0000250|UniProtKB:Q9HCU5}.
uniprot
proteins
transmembrane_region
TRANSMEM 389..409; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins