Spns2
entrez
216892
canonical
uniprot
Q91VM4
canonical
ensembl
ENSMUSG00000040447
resolver
ensp
ENSMUSP00000044418
resolver
ensp
ENSMUSP00000248551
resolver
ensp
ENSMUSP00000248553
resolver
ensp
ENSMUSP00000248556
resolver
genesymbol
Spns2
resolver
uniprot
B9A1T4
resolver
uniprot
Q5F242
resolver
uniprot
Q8R119
resolver
uniprot_entry
SPNS2_MOUSE
resolver
uniprot_sec
B9A1T4
resolver
uniprot_sec
Q5F242
resolver
uniprot_sec
Q8R119
resolver
amino_acid_sequence
MMCLECASAAAGGAEEEEADAERRRRRRGAQPGAGGSACCGARGVGGAGVVSADEEVQTLSGSVRRVPSGLPSIPSTPGCAAAAKGPSAPQPKPASLGRGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVSPVLGMITGTLILILVPATKRGHADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVQKTAETCNSPPCGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRADPLVCAVGMLGSAIFICLIFVAAKTSIVGAYICIFVGETLLFSNWAITADILMYVVIPTRRATAVALQSFTSHLLGDAGSPYLIGFISDLIRQSTKDSPLWEFLSLGYALMLCPFVVVLGGMFFLATALFFLSDRAKAEQQVNQLVMPPASVKV
uniprot
proteins
function
FUNCTION: Lipid transporter that specifically mediates export of sphingosine-1-phosphate (sphing-4-enine 1-phosphate, S1P) and sphinganine-1-phosphate in the lymph, thereby playing a role in lymphocyte trafficking (PubMed:22406534, PubMed:22664872, PubMed:23103166, PubMed:23180825, PubMed:34260944). S1P is a bioactive signaling molecule that regulates many physiological processes important for the development and for the immune system (PubMed:22406534, PubMed:22664872, PubMed:23103166, PubMed:23180825, PubMed:34260944). Regulates levels of S1P and the S1P gradient that exists between the high circulating concentrations of S1P and low tissue levels that control lymphocyte trafficking (PubMed:22406534, PubMed:22664872, PubMed:23180825, PubMed:34260944). Required for the egress of T-cells from lymph nodes during an immune response by mediating S1P secretion, which generates a gradient that enables activated T-cells to access lymph (PubMed:22406534, PubMed:34260944). Also required for the egress of immature B-cells from the bone marrow (PubMed:22406534). In contrast, it does not mediate S1P release from red blood cells (PubMed:22406534, PubMed:23103166). Involved in auditory function: S1P release in the inner ear is required for maintenance of the endocochlear potential in the cochlea (PubMed:25356849). In addition to export, also able to mediate S1P import (PubMed:33785361). {ECO:0000269|PubMed:22406534, ECO:0000269|PubMed:22664872, ECO:0000269|PubMed:23103166, ECO:0000269|PubMed:23180825, ECO:0000269|PubMed:25356849, ECO:0000269|PubMed:33785361, ECO:0000269|PubMed:34260944}.
uniprot
proteins
mass_dalton
58196
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Spinster (TC 2.A.1.49) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19074308
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22406534
uniprot
proteins
pubmed
22664872
uniprot
proteins
pubmed
23103166
uniprot
proteins
pubmed
23180825
uniprot
proteins
pubmed
25356849
uniprot
proteins
pubmed
30973865
uniprot
proteins
pubmed
33785361
uniprot
proteins
pubmed
34260944
uniprot
proteins
sequence_length
549
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:A2SWM2}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000250|UniProtKB:A2SWM2}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 141..161; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 169..189; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 202..222; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 229..249; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 261..281; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 320..340; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 364..384; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 398..418; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 422..442; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 466..486; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 507..527; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins