NMUR1
entrez
10316
canonical
uniprot
Q9HB89
canonical
ensembl
ENSG00000171596
resolver
ensp
ENSP00000305877
resolver
enst
ENST00000305141
resolver
genesymbol
NMUR1
resolver
genesymbol_syn
GPR66
resolver
genesymbol_syn
NMU1
resolver
hgnc
HGNC:4518
resolver
uniprot
O43664
resolver
uniprot
Q7LDP6
resolver
uniprot
Q8NE20
resolver
uniprot_entry
NMUR1_HUMAN
resolver
uniprot_sec
O43664
resolver
uniprot_sec
Q7LDP6
resolver
uniprot_sec
Q8NE20
resolver
amino_acid_sequence
MTPLCLNCSVLPGDLYPGGARNPMACNGSAARGHFDPEDLNLTDEALRLKYLGPQQTELFMPICATYLLIFVVGAVGNGLTCLVILRHKAMRTPTNYYLFSLAVSDLLVLLVGLPLELYEMWHNYPFLLGVGGCYFRTLLFEMVCLASVLNVTALSVERYVAVVHPLQARSMVTRAHVRRVLGAVWGLAMLCSLPNTSLHGIRQLHVPCRGPVPDSAVCMLVRPRALYNMVVQTTALLFFCLPMAIMSVLYLLIGLRLRRERLLLMQEAKGRGSAAARSRYTCRLQQHDRGRRQVTKMLFVLVVVFGICWAPFHADRVMWSVVSQWTDGLHLAFQHVHVISGIFFYLGSAANPVLYSLMSSRFRETFQEALCLGACCHRLRPRHSSHSLSRMTTGSTLCDVGSLGSWVHPLAGNDGPEAQQETDPS
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for the neuropeptides neuromedin-U (NMU) and neuromedin-S (NMS) (PubMed:10899166, PubMed:15635449, PubMed:35440625). Functionally, is involved in pleiotropic roles, including regulation of feeding, energy balance, blood pressure and smooth muscle contraction (By similarity). Additionally modulates hormone release and inflammatory responses in a tissue- and receptor-dependent manner (By similarity). Mechanistically, upon ligand binding, couples to Galpha proteins, namely GNAQ/Gaq or GNA11/Ga11 and GNAI1/Gai subunits (PubMed:15331768). GNAQ/Gaq or GNA11/Ga11 coupling activatse a phospholipase C (PLC), hydrolyzing PIP2 (phosphatidylinositol 4,5-bisphosphate) into DAG (diacylglycerol) and IP3 (inositol trisphosphate) and mobilizing intracellular calcium via IP3 receptors on the endoplasmic reticulum (PubMed:10899166, PubMed:15331768). Also couples to GNAI1/Gai to inhibit forskolin-stimulated cAMP accumulation (PubMed:15331768). In pancreatic beta cells, through neuromedin U-25, regulates insulin secretion where it coupled to GNAI2 and GNAO1, resulting in reduced intracellular Ca2+ influx and cAMP levels (By similarity). Through neuromedin U-25 in Th2-type T cells, enhances type 2 cytokine secretion and modulates inflammatory responses via activation of PLC-calcineurin-MEK and PI3K signaling pathways (By similarity). {ECO:0000250|UniProtKB:O55040, ECO:0000250|UniProtKB:P12760, ECO:0000250|UniProtKB:Q9JJI5, ECO:0000269|PubMed:10899166, ECO:0000269|PubMed:15331768, ECO:0000269|PubMed:15635449, ECO:0000269|PubMed:35440625}.
uniprot
proteins
mass_dalton
47351
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10899166
uniprot
proteins
pubmed
15331768
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15635449
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
35440625
uniprot
proteins
pubmed
9782091
uniprot
proteins
sequence_length
426
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:15331768}; Multi-pass membrane protein {ECO:0000269|PubMed:35440625}.
uniprot
proteins
transmembrane_region
TRANSMEM 66..86; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:35440625"; TRANSMEM 98..118; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:35440625"; TRANSMEM 139..161; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:35440625"; TRANSMEM 182..202; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:35440625"; TRANSMEM 236..256; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:35440625"; TRANSMEM 295..315; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:35440625"; TRANSMEM 339..359; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:35440625
uniprot
proteins