TSPAN15
entrez
23555
canonical
uniprot
O95858
canonical
ensembl
ENSG00000099282
resolver
ensp
ENSP00000362387
resolver
ensp
ENSP00000528358
resolver
ensp
ENSP00000528362
resolver
ensp
ENSP00000696821
resolver
enst
ENST00000373290
resolver
genesymbol
TSPAN15
resolver
genesymbol_syn
NET7
resolver
genesymbol_syn
TM4SF15
resolver
hgnc
HGNC:23298
resolver
uniprot
Q6UW79
resolver
uniprot_entry
TSN15_HUMAN
resolver
uniprot_sec
Q6UW79
resolver
amino_acid_sequence
MPRGDSEQVRYCARFSYLWLKFSLIIYSTVFWLIGALVLSVGIYAEVERQKYKTLESAFLAPAIILILLGVVMFMVSFIGVLASLRDNLYLLQAFMYILGICLIMELIGGVVALTFRNQTIDFLNDNIRRGIENYYDDLDFKNIMDFVQKKFKCCGGEDYRDWSKNQYHDCSAPGPLACGVPYTCCIRNTTEVVNTMCGYKTIDKERFSVQDVIYVRGCTNAVIIWFMDNYTIMAGILLGILLPQFLGVLLTLLYITRVEDIIMEHSVTDGLLGPGAKPSVEAAGTGCCLCYPN
uniprot
proteins
function
FUNCTION: Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates (PubMed:26686862, PubMed:30463011, PubMed:31792032, PubMed:34739841). Promotes ADAM10-mediated cleavage of CDH2 (PubMed:34739841). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (PubMed:26686862, PubMed:31792032). {ECO:0000269|PubMed:26686862, ECO:0000269|PubMed:30463011, ECO:0000269|PubMed:31792032, ECO:0000269|PubMed:34739841}.
uniprot
proteins
mass_dalton
33165
uniprot
proteins
mutagenesis
MUTAGEN 166..169; /note="NQYH->AQAA: Alsmost abolishes interaction with ADAM10. Decreases maturation of ADAM10 and CDH2/N-cadherin cleavage."; /evidence="ECO:0000269|PubMed:34739841"; MUTAGEN 193..196; /note="VVNT->AVAA: No effect on interaction with ADAM10. Decreases maturation of ADAM10. No effect on CDH2/N-cadherin cleavage."; /evidence="ECO:0000269|PubMed:34739841"; MUTAGEN 204..206; /note="DKE->AAA: No effect on interaction with ADAM10. No effect on maturation of ADAM10. No effect on CDH2/N-cadherin cleavage."; /evidence="ECO:0000269|PubMed:34739841"; MUTAGEN 288..291; /note="CCLC->AALA: Strongly reduces palmitoylation levels."; /evidence="ECO:0000269|PubMed:31792032
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. {ECO:0000269|PubMed:31792032}.
uniprot
proteins
protein_family
Tetraspanin (TM4SF) family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
26686862
uniprot
proteins
pubmed
30463011
uniprot
proteins
pubmed
31792032
uniprot
proteins
pubmed
34739841
uniprot
proteins
pubmed
37516108
uniprot
proteins
sequence_length
294
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26686862, ECO:0000269|PubMed:30463011, ECO:0000269|PubMed:31792032}; Multi-pass membrane protein {ECO:0000305}. Late endosome membrane {ECO:0000269|PubMed:26686862}.
uniprot
proteins
transmembrane_region
TRANSMEM 24..44; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 63..83; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 94..114; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 236..256; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins