RGCC
entrez
28984
canonical
uniprot
Q9H4X1
canonical
ensembl
ENSG00000102760
resolver
ensp
ENSP00000368664
resolver
genesymbol
RGCC
resolver
genesymbol_syn
C13orf15
resolver
genesymbol_syn
RGC32
resolver
hgnc
HGNC:20369
resolver
uniprot
Q6NZ48
resolver
uniprot
Q9UL69
resolver
uniprot_entry
RGCC_HUMAN
resolver
uniprot_sec
Q6NZ48
resolver
uniprot_sec
Q9UL69
resolver
amino_acid_sequence
MKPPAAQGSPAAAAAAAPALDSAAAEDLSDALCEFDAVLADFASPFHERHFHYEEHLERMKRRSSASVSDSSGFSDSESADSLYRNSFSFSDEKLNSPTDSTPALLSATVTPQKAKLGDTKELEAFIADLDKTLASM
uniprot
proteins
function
FUNCTION: Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation. {ECO:0000269|PubMed:11687586, ECO:0000269|PubMed:17146433, ECO:0000269|PubMed:19158077, ECO:0000269|PubMed:22163048}.
uniprot
proteins
mass_dalton
14559
uniprot
proteins
mutagenesis
MUTAGEN 111; /note="T->A: Loss of phosphorylation. Reduced stimulation of CDK1 activity."; /evidence="ECO:0000269|PubMed:11687586
uniprot
proteins
pubmed
11687586
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15713436
uniprot
proteins
pubmed
17146433
uniprot
proteins
pubmed
19158077
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
22163048
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
137
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic in unstimulated cells. Nuclear after activation by complement. Associated with the centrosome during prometaphase and metaphase.
uniprot
proteins