Ldah
entrez
68832
canonical
uniprot
Q8BVA5
canonical
ensembl
ENSMUSG00000037669
resolver
ensp
ENSMUSP00000042285
resolver
ensp
ENSMUSP00000129424
resolver
ensp
ENSMUSP00000151612
resolver
ensp
ENSMUSP00000216332
resolver
ensp
ENSMUSP00000216333
resolver
ensp
ENSMUSP00000216337
resolver
ensp
ENSMUSP00000216349
resolver
ensp
ENSMUSP00000216355
resolver
enst
ENSMUST00000037383
resolver
enst
ENSMUST00000169104
resolver
enst
ENSMUST00000218086
resolver
genesymbol
Ldah
resolver
uniprot
A0A0F6AIX5
resolver
uniprot
A0A0F6AIX6
resolver
uniprot
A0A1W2P7C8
resolver
uniprot
A0AAR0Q0P9
resolver
uniprot
A0AAR0SQ87
resolver
uniprot
Q3TRE7
resolver
uniprot
Q5RL52
resolver
uniprot
Q6PG15
resolver
uniprot
Q8BVV0
resolver
uniprot_entry
A0A0F6AIX6_MOUSE
resolver
uniprot_entry
A0AAR0Q0P9_MOUSE
resolver
uniprot_entry
A0AAR0SQ87_MOUSE
resolver
uniprot_entry
LDAH_MOUSE
resolver
uniprot_sec
A0A0F6AIX5
resolver
uniprot_sec
A0A1W2P7C8
resolver
uniprot_sec
Q3TRE7
resolver
uniprot_sec
Q5RL52
resolver
uniprot_sec
Q6PG15
resolver
uniprot_sec
Q8BVV0
resolver
amino_acid_sequence
MASEVEEQIPVREEFFLCGGVETKIIKCGPWTNLFEKQDVSKPKQLIFIIPGNPGYSAFYVPFAKALYTLMKSRFPVWIISHAGFSVTPKDKKVLAAPQEESNAQKIEDVYGLNGQIEHKIAFLRAHVPKDVKLILIGHSVGTYMTLHVMKRVLELPVAHAFLLFPTIERMSESPNGKFATPFLCQFRYLLYATSYLLFKPCPEVIKSFIIQKLMGQMNIKLELPLTDILQPFCLANAAYLGSQEMVQIVKRDDDIIKEFLPKLKFYYGKTDGWCPVKYYEDMKKDFPEGNIYLCEKGIPHAFVLDFSQEMATIVAEWINNRPPRK
uniprot
proteins
ec_number
3.1.1.13
uniprot
proteins
function
FUNCTION: Probable serine lipid hydrolase associated with lipid droplets (PubMed:24357060, PubMed:28578400). Has low cholesterol esterase activity (PubMed:24357060, PubMed:27836991). Appears to lack triglyceride lipase activity (PubMed:23525007, PubMed:24357060, PubMed:27836991). Involved in cholesterol and triglyceride homeostasis; stimulates cellular triglyceride accumulation and cellular cholesterol release (PubMed:24357060, PubMed:28578400). Acts antagonistically with PNPLA2/ATGL in regulation of cellular lipid stores (PubMed:28578400). May regulate triglyceride accumulation indirectly through stimulation of PNPLA2/ATGL ubiquitination and proteasomal degradation (PubMed:28578400). Promotes microtubule-dependent lipid droplet fusion (PubMed:28578400). Highly expressed in macrophage-rich areas in atherosclerotic lesions, suggesting that it could promote cholesterol ester turnover in macrophages (PubMed:24357060). {ECO:0000269|PubMed:23525007, ECO:0000269|PubMed:24357060, ECO:0000269|PubMed:27836991, ECO:0000269|PubMed:28578400}.; FUNCTION: [Isoform 1]: Stimulates cellular triglyceride accumulation and lipid droplet fusion. {ECO:0000269|PubMed:28578400}.; FUNCTION: [Isoform 2]: Associates with lipid droplets but does not stimulate cellular triglyceride accumulation, lipid droplet fusion or ATGL proteasomal degradation. {ECO:0000269|PubMed:28578400}.; FUNCTION: [Isoform 3]: Stimulates cellular triglyceride accumulation and lipid droplet fusion. {ECO:0000269|PubMed:28578400}.
uniprot
proteins
mass_dalton
37374
uniprot
proteins
mutagenesis
MUTAGEN 127; /note="H->A: No effect on cellular triglyceride accumulation."; /evidence="ECO:0000269|PubMed:28578400"; MUTAGEN 140; /note="S->A: Reduces cholesterol efflux but no effect on cellular triglyceride accumulation."; /evidence="ECO:0000269|PubMed:28578400"; MUTAGEN 140; /note="S->C: Abolishes active hydrolase probe binding in serine hydrolase assays. Abrogates cholesterol esterase activity and reduces cholesterol efflux. No effect on lipid droplet localization."; /evidence="ECO:0000269|PubMed:24357060, ECO:0000269|PubMed:28578400"; MUTAGEN 301; /note="H->A: No effect on cellular triglyceride accumulation."; /evidence="ECO:0000269|PubMed:28578400
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
protein_family
LDAH family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23525007
uniprot
proteins
pubmed
24357060
uniprot
proteins
pubmed
27836991
uniprot
proteins
pubmed
28578400
uniprot
proteins
sequence_length
326
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lipid droplet {ECO:0000269|PubMed:23525007, ECO:0000269|PubMed:24357060, ECO:0000269|PubMed:28578400}. Endoplasmic reticulum {ECO:0000269|PubMed:23525007}. Note=Localizes to the endoplasmic reticulum in absence of lipid droplets and translocates to lipid droplets upon lipid storage induction (PubMed:23525007). Lipid droplet localization does not require hydrolase activity (PubMed:28578400). {ECO:0000269|PubMed:23525007, ECO:0000269|PubMed:28578400}.
uniprot
proteins