Tacr3
entrez
24808
canonical
uniprot
P16177
canonical
ensembl
ENSRNOG00000009372
resolver
ensembl
ENSRNOG00055011178
resolver
ensembl
ENSRNOG00060020788
resolver
ensembl
ENSRNOG00065015568
resolver
ensp
ENSRNOP00000012473
resolver
ensp
ENSRNOP00055015309
resolver
ensp
ENSRNOP00060029612
resolver
ensp
ENSRNOP00065020339
resolver
enst
ENSRNOT00000012473
resolver
enst
ENSRNOT00055018963
resolver
enst
ENSRNOT00060035985
resolver
enst
ENSRNOT00065025853
resolver
genesymbol
Tacr3
resolver
genesymbol_syn
Tac3r
resolver
uniprot_entry
NK3R_RAT
resolver
amino_acid_sequence
MASVPRGENWTDGTVEVGTHTGNLSSALGVTEWLALQAGNFSSALGLPATTQAPSQVRANLTNQFVQPSWRIALWSLAYGLVVAVAVFGNLIVIWIILAHKRMRTVTNYFLVNLAFSDASVAAFNTLINFIYGLHSEWYFGANYCRFQNFFPITAVFASIYSMTAIAVDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKIKVMPGRTLCYVQWPEGPKQHFTYHIIVIILVYCFPLLIMGVTYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKMMIIVVVTFAICWLPYHVYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLNKRFRAGFKRAFRWCPFIQVSSYDELELKTTRFHPTRQSSLYTVSRMESVTVLFDPNDGDPTKSSRKKRAVPRDPSANGCSHRGSKSASTTSSFISSPYTSVDEYS
uniprot
proteins
function
FUNCTION: Receptor for the tachykinin neuromedin-K (neurokinin B), also able to bind and respond to tachynins substance K/neurokinin A and substance P (PubMed:2153106, PubMed:1370820). The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P (PubMed:2153106, PubMed:1370820). Neuromedin-K binding to its receptor triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C (PubMed:1370820). Neuromedin-K binding also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP) (PubMed:1370820). {ECO:0000269|PubMed:1370820, ECO:0000269|PubMed:2153106}.
uniprot
proteins
mass_dalton
51107
uniprot
proteins
post_translational_modification
PTM: The anchoring of this receptor to the plasma membrane is probably mediated by the palmitoylation of a cysteine residue.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
1370820
uniprot
proteins
pubmed
2153106
uniprot
proteins
sequence_length
452
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P29371}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 72..94; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 105..126; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 147..168; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 189..209; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 233..257; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 287..308; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 322..346; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins