Dnph1
entrez
171047
canonical
uniprot
O35820
canonical
ensembl
ENSRNOG00000018397
resolver
ensembl
ENSRNOG00055007305
resolver
ensembl
ENSRNOG00060025743
resolver
ensembl
ENSRNOG00065026194
resolver
ensp
ENSRNOP00000024815
resolver
ensp
ENSRNOP00055009664
resolver
ensp
ENSRNOP00060036891
resolver
ensp
ENSRNOP00065037057
resolver
enst
ENSRNOT00000024815
resolver
enst
ENSRNOT00055012173
resolver
enst
ENSRNOT00060044530
resolver
enst
ENSRNOT00065045181
resolver
genesymbol
Dnph1
resolver
genesymbol_syn
Rcl
resolver
uniprot_entry
DNPH1_RAT
resolver
amino_acid_sequence
MAASGEQAPCSVYFCGSIRGGREDQALYARIVSRLRRYGKVLTEHVADAELEPLGEEAAGGDQFIHEQDLNWLQQADVVVAEVTQPSLGVGYELGRAVALGKPILCLFRPQSGRVLSAMIRGAADGSRFQVWDYAEGEVETMLDRYFEAYLPQKTASSSHPSA
uniprot
proteins
ec_number
3.2.2.-
uniprot
proteins
function
FUNCTION: Part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate). Catalyzes the second step in that pathway, the hydrolysis of the N-glycosidic bond in hmdUMP, degrading this cytotoxic nucleotide to avoid its genomic integration. {ECO:0000250|UniProtKB:O43598}.
uniprot
proteins
mass_dalton
17781
uniprot
proteins
mutagenesis
MUTAGEN 13; /note="Y->A: 100-fold decrease binding affinity for GMP as substrate."; /evidence="ECO:0000269|PubMed:19720067"; MUTAGEN 93; /note="E->A: 100-fold increase in Km and 170-fold decrease in catalytic efficiency for dGMP as substrate."; /evidence="ECO:0000269|PubMed:17234634, ECO:0000269|PubMed:19720067
uniprot
proteins
protein_family
2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family
uniprot
proteins
pubmed
17234634
uniprot
proteins
pubmed
19720067
uniprot
proteins
pubmed
19822152
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23385460
uniprot
proteins
pubmed
24260472
uniprot
proteins
pubmed
25108359
uniprot
proteins
pubmed
9271375
uniprot
proteins
sequence_length
163
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O43598}. Nucleus {ECO:0000269|PubMed:9271375}.
uniprot
proteins