Gripap1
entrez
116493
canonical
uniprot
Q9JHZ4
canonical
ensembl
ENSRNOG00000009071
resolver
ensembl
ENSRNOG00055028286
resolver
ensembl
ENSRNOG00060024104
resolver
ensembl
ENSRNOG00065011223
resolver
ensp
ENSRNOP00000012646
resolver
ensp
ENSRNOP00000081274
resolver
ensp
ENSRNOP00000085406
resolver
ensp
ENSRNOP00000097700
resolver
enst
ENSRNOT00000102832
resolver
genesymbol
Gripap1
resolver
genesymbol_syn
Grasp1
resolver
uniprot
A0A8I6ARM9
resolver
uniprot
Q9JHZ3
resolver
uniprot_entry
A0A8I6ARM9_RAT
resolver
uniprot_entry
GRAP1_RAT
resolver
uniprot_sec
Q9JHZ3
resolver
amino_acid_sequence
MAQALSEEEFQRMQTQLLELRTNNYQLSDELRKNGVELSSLRQKVAYLDKEFSKAQKALSKSKKAQEVEVLLSEKEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQLEQLELENRQLKEGVPGAAGPHVDGELLRLQAENTALQKNMAALQERYGKEAVRPSAVSEGQGDPPGDVLPISLSPMPLAEVELKWEMEREEKKLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADLKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQVSSQSADAQEQVEGLLAENNALRTSLAALEQIQTAKTQELNMLREQNTELAAELKHRQADYEELMGQKDDLNSQLQESLRANSRLLEQLQEMGQEKEQLIQDLQEARKSAEKRKVMLDELAMETLQEKSQHKEELGAVRLRHEKEMLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELENLQHTVEELQAQVHSMDGAKGWFERRLKEAEESLLQQEQEQEETLKQCREQHAAELKGKEEELQNVRDQLQQAQEERDGHVKTISNLKQEVKDTVDGQRILEKKGSAVLKDLKRQLHLERKRADKLQERLQEILTNSKSRTGLEELVLSEMNSPSRTQTGDSSSVSSFSYREILKEKESSAIPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLTKNMHLHKDMEVLSQEIVRLSKECVGSPDPDLEPGEAN
uniprot
proteins
function
FUNCTION: Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity. {ECO:0000269|PubMed:20098723}.; FUNCTION: [GRASP-1 C-terminal chain]: Functions as a scaffold protein in neurons to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity. {ECO:0000269|PubMed:17761173}.
uniprot
proteins
mass_dalton
96074
uniprot
proteins
mutagenesis
MUTAGEN 591; /note="D->E: No in vitro cleavage by caspase-3; when associated with E-594. Results in loss of JNK activation; when associated with E-594."; /evidence="ECO:0000269|PubMed:10896157, ECO:0000269|PubMed:20098723"; MUTAGEN 594; /note="D->E: No in vitro cleavage by caspase-3; when associated with E-591. Results in loss of JNK activation; when associated with E-591."; /evidence="ECO:0000269|PubMed:10896157, ECO:0000269|PubMed:20098723
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved by caspase-3 (PubMed:10896157). A minor C-terminal proteolytic fragment of 30 kDa is produced (PubMed:10896157). Proteolytic cleavage is required for JNK signaling activation (PubMed:17761173). {ECO:0000269|PubMed:10896157, ECO:0000269|PubMed:17761173}.
uniprot
proteins
pubmed
10896157
uniprot
proteins
pubmed
17761173
uniprot
proteins
pubmed
20098723
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
837
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:20098723}; Peripheral membrane protein {ECO:0000305}. Recycling endosome membrane {ECO:0000269|PubMed:20098723}; Peripheral membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000269|PubMed:20098723}. Cell projection, dendrite {ECO:0000269|PubMed:20098723}. Synapse {ECO:0000269|PubMed:20098723}. Note=Localizes to recycling endosomal tubules that are emanating from early endosomes. {ECO:0000269|PubMed:20098723}.
uniprot
proteins