PLA2G2F
entrez
64600
canonical
uniprot
Q9BZM2
canonical
ensembl
ENSG00000158786
resolver
ensp
ENSP00000364243
resolver
genesymbol
PLA2G2F
resolver
hgnc
HGNC:30040
resolver
uniprot
Q5R385
resolver
uniprot
Q8N217
resolver
uniprot
Q9H506
resolver
uniprot_entry
PA2GF_HUMAN
resolver
uniprot_sec
Q5R385
resolver
uniprot_sec
Q8N217
resolver
uniprot_sec
Q9H506
resolver
amino_acid_sequence
MKKFFTVAILAGSVLSTAHGSLLNLKAMVEAVTGRSAILSFVGYGCYCGLGGRGQPKDEVDWCCHAHDCCYQELFDQGCHPYVDHYDHTIENNTEIVCSDLNKTECDKQTCMCDKNMVLCLMNQTYREEYRGFLNVYCQGPTPNCSIYEPPPEEVTCSHQSPAPPAPP
uniprot
proteins
ec_number
3.1.1.4
uniprot
proteins
function
FUNCTION: Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at the sn-2 position of phospholipids (phospholipase A2 activity), the catalytic efficiency decreasing in the following order: phosphatidylglycerols > phosphatidylethanolamines > phosphatidylcholines > phosphatidylserines (PubMed:11112443). May play a role in lipid mediator production in inflammatory conditions, by providing arachidonic acid to downstream cyclooxygenases and lipoxygenases (By similarity). {ECO:0000250|UniProtKB:Q9QZT4, ECO:0000269|PubMed:11112443}.
uniprot
proteins
mass_dalton
18658
uniprot
proteins
protein_family
Phospholipase A2 family
uniprot
proteins
pubmed
11112443
uniprot
proteins
pubmed
11877435
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16710414
uniprot
proteins
sequence_length
168
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Secreted {ECO:0000250|UniProtKB:Q9QZT4}. Cell membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9QZT4}.
uniprot
proteins