Ghitm
entrez
290596
canonical
uniprot
Q5XIA8
canonical
ensembl
ENSRNOG00000013961
resolver
ensembl
ENSRNOG00055010437
resolver
ensembl
ENSRNOG00060011132
resolver
ensembl
ENSRNOG00065020666
resolver
ensp
ENSRNOP00000077387
resolver
ensp
ENSRNOP00055014219
resolver
ensp
ENSRNOP00060014676
resolver
ensp
ENSRNOP00065028145
resolver
enst
ENSRNOT00000106368
resolver
enst
ENSRNOT00055017660
resolver
enst
ENSRNOT00060018833
resolver
enst
ENSRNOT00065035018
resolver
genesymbol
Ghitm
resolver
genesymbol_syn
Mics1
resolver
uniprot_entry
GHITM_RAT
resolver
amino_acid_sequence
MLAARLVCLRTLPSRVFQPTFITKASPLVKNSITKNQWLLTPSREYATKTRIRTHRGKTGQELKEAALEPSLEKVFKIDQMGKWFVAGGAAVGLGALCYYGLGMSNEIGAIEKAVIWPQYVKDRIHSTYMYLAGSIGLTALSALALARSPALMNFMMTGSWMTIGATFAAMIGAGMLVQSISYEQSPGPKHLAWMLHSGVMGAVVAPLTILGGPLLLRAAWYTAGIVGGLSTVAMCAPSEKFLNMGAPLGVGLGLVFASSLGSMFLPPTSVAGATLYSVAMYGGLVLFSMFLLYDTQKVVKRAEITPAYGAQKYDPINSMLTIYMDTLNIFMRVATMLATGSNRKK
uniprot
proteins
function
FUNCTION: Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport (By similarity). Mediates proton-dependent calcium efflux from mitochondrion (By similarity). Also functions as an electroneutral mitochondrial proton/potassium exchanger (By similarity). Required for the mitochondrial tubular network and cristae organization (By similarity). Involved in apoptotic release of cytochrome c (By similarity). Inhibits AFG3L2 proteolytic activity, stimulating respiration and stabilizing respiratory enzymes in actively respiring mitochondria (By similarity). However, when mitochondria become hyperpolarized, GHITM loses its inhibitory activity toward AFG3L2 and the now active AFG3L2 turns first on GHITM and, if hyperpolarization persists, on other proteins of the mitochondria, leading to a broad remodeling of the proteome (By similarity). {ECO:0000250|UniProtKB:Q9H3K2}.
uniprot
proteins
mass_dalton
37178
uniprot
proteins
post_translational_modification
PTM: Undergoes AFG3L2-mediated proteolytic degradation, upon hyperpolarization of mitochondria. {ECO:0000250|UniProtKB:Q9H3K2}.
uniprot
proteins
protein_family
BI1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
346
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9H3K2}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 84..104; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 127..147; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 161..181; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 192..212; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 215..235; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 246..266; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 273..293; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins