FBXO16
entrez
157574
canonical
uniprot
Q8IX29
canonical
ensembl
ENSG00000214050
resolver
ensp
ENSP00000369604
resolver
ensp
ENSP00000429687
resolver
genesymbol
FBXO16
resolver
genesymbol_syn
FBX16
resolver
hgnc
HGNC:13618
resolver
uniprot
Q3T1B2
resolver
uniprot
Q3T1B3
resolver
uniprot
Q3T1B4
resolver
uniprot_entry
FBX16_HUMAN
resolver
uniprot_sec
Q3T1B2
resolver
uniprot_sec
Q3T1B3
resolver
uniprot_sec
Q3T1B4
resolver
amino_acid_sequence
MMAFAPPKNTDGPKMQTKMSTWTPLNHQLLNDRVFEERRALLGKWFDKWTDSQRRRILTGLLERCSLSQQKFCCRKLQEKIPAEALDFTTKLPRVLSLYIFSFLDPRSLCRCAQVCWHWKNLAELDQLWMLKCLRFNWYINFSPTPFEQGIWKKHYIQMVKELHITKPKTPPKDGFVIADVQLVTSNSPEEKQSPLSAFRSSSSLRKKNNSGEKALPPWRSSDKHPTDIIRFNYLDNRDPMETVQQGRRKRNQMTPDFSRQSHDKKNKLQDRTRLRKAQSMMSRRNPFPLCP
uniprot
proteins
function
FUNCTION: Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Functions as a putative tumor suppressor by targeting nuclear beta-catenin/CTNNB1 for degradation independently of upstream activating signals, thereby inhibiting epithelial-to-mesenchymal transition (PubMed:30714168). Controls the ubiquitination and degradation of hnRNPL (PubMed:34333526). Negatively regulates NF-kappa-B signaling by mediating the polyubiquitination and degradation of RELA (PubMed:40529355). Inhibits autophagy by promoting 'Lys-48'-linked polyubiquitination of the serine/threonine-protein kinase ULK1 (PubMed:39384743). {ECO:0000269|PubMed:30714168, ECO:0000269|PubMed:34333526, ECO:0000269|PubMed:39384743, ECO:0000269|PubMed:40529355}.
uniprot
proteins
mass_dalton
34588
uniprot
proteins
pubmed
12243353
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
30714168
uniprot
proteins
pubmed
34333526
uniprot
proteins
pubmed
39384743
uniprot
proteins
pubmed
40529355
uniprot
proteins
sequence_length
292
uniprot
proteins