TNPO1
entrez
3842
canonical
uniprot
Q92973
canonical
ensembl
ENSG00000083312
resolver
ensp
ENSP00000336712
resolver
ensp
ENSP00000425118
resolver
ensp
ENSP00000428899
resolver
ensp
ENSP00000506620
resolver
ensp
ENSP00000565536
resolver
ensp
ENSP00000647175
resolver
enst
ENST00000679378
resolver
genesymbol
TNPO1
resolver
genesymbol_syn
KPNB2
resolver
genesymbol_syn
MIP1
resolver
genesymbol_syn
TRN
resolver
hgnc
HGNC:6401
resolver
uniprot
A0A7P0TBF0
resolver
uniprot
B4DVC6
resolver
uniprot
Q92957
resolver
uniprot
Q92975
resolver
uniprot_entry
A0A7P0TBF0_HUMAN
resolver
uniprot_entry
TNPO1_HUMAN
resolver
uniprot_sec
B4DVC6
resolver
uniprot_sec
Q92957
resolver
uniprot_sec
Q92975
resolver
amino_acid_sequence
MVWDRQTKMEYEWKPDEQGLQQILQLLKESQSPDTTIQRTVQQKLEQLNQYPDFNNYLIFVLTKLKSEDEPTRSLSGLILKNNVKAHFQNFPNGVTDFIKSECLNNIGDSSPLIRATVGILITTIASKGELQNWPDLLPKLCSLLDSEDYNTCEGAFGALQKICEDSAEILDSDVLDRPLNIMIPKFLQFFKHSSPKIRSHAVACVNQFIISRTQALMLHIDSFIENLFALAGDEEPEVRKNVCRALVMLLEVRMDRLLPHMHNIVEYMLQRTQDQDENVALEACEFWLTLAEQPICKDVLVRHLPKLIPVLVNGMKYSDIDIILLKGDVEEDETIPDSEQDIRPRFHRSRTVAQQHDEDGIEEEDDDDDEIDDDDTISDWNLRKCSAAALDVLANVYRDELLPHILPLLKELLFHHEWVVKESGILVLGAIAEGCMQGMIPYLPELIPHLIQCLSDKKALVRSITCWTLSRYAHWVVSQPPDTYLKPLMTELLKRILDSNKRVQEAACSAFATLEEEACTELVPYLAYILDTLVFAFSKYQHKNLLILYDAIGTLADSVGHHLNKPEYIQMLMPPLIQKWNMLKDEDKDLFPLLECLSSVATALQSGFLPYCEPVYQRCVNLVQKTLAQAMLNNAQPDQYEAPDKDFMIVALDLLSGLAEGLGGNIEQLVARSNILTLMYQCMQDKMPEVRQSSFALLGDLTKACFQHVKPCIADFMPILGTNLNPEFISVCNNATWAIGEISIQMGIEMQPYIPMVLHQLVEIINRPNTPKTLLENTAITIGRLGYVCPQEVAPMLQQFIRPWCTSLRNIRDNEEKDSAFRGICTMISVNPSGVIQDFIFFCDAVASWINPKDDLRDMFCKILHGFKNQVGDENWRRFSDQFPLPLKERLAAFYGV
uniprot
proteins
function
FUNCTION: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:24753571). May mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones (By similarity). In vitro, mediates nuclear import of SRP19 (PubMed:11682607). Mediates nuclear import of ADAR/ADAR1 isoform 1 and isoform 5 in a RanGTP-dependent manner (PubMed:19124606, PubMed:24753571). Main mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with the karyopherins KPNA1 and KPNA2 (PubMed:35446349). {ECO:0000250|UniProtKB:Q8BFY9, ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:19124606, ECO:0000269|PubMed:24753571, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:8986607, ECO:0000269|PubMed:9687515}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000269|PubMed:16704975}.
uniprot
proteins
mass_dalton
102355
uniprot
proteins
mutagenesis
MUTAGEN 468; /note="W->A: Abolishes interaction with the ADAR nuclear localization signal. Abolishes ADAR nuclear import."; /evidence="ECO:0000269|PubMed:24753571"; MUTAGEN 738; /note="W->A: Abolishes interaction with the ADAR nuclear localization signal. Abolishes ADAR nuclear import."; /evidence="ECO:0000269|PubMed:24753571
uniprot
proteins
protein_family
Importin beta family
uniprot
proteins
protein_family
Importin beta-2 subfamily
uniprot
proteins
pubmed
10353245
uniprot
proteins
pubmed
11682607
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16704975
uniprot
proteins
pubmed
19124606
uniprot
proteins
pubmed
19386897
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
24753571
uniprot
proteins
pubmed
35446349
uniprot
proteins
pubmed
8808633
uniprot
proteins
pubmed
8986607
uniprot
proteins
pubmed
9144189
uniprot
proteins
pubmed
9351834
uniprot
proteins
pubmed
9428644
uniprot
proteins
pubmed
9524220
uniprot
proteins
pubmed
9687515
uniprot
proteins
sequence_length
898
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
uniprot
proteins