GLUD2
entrez
2747
canonical
uniprot
P49448
canonical
ensembl
ENSG00000182890
resolver
ensembl
ENSG00000288118
resolver
ensp
ENSP00000327589
resolver
ensp
ENSP00000500546
resolver
enst
ENST00000328078
resolver
enst
ENST00000673493
resolver
genesymbol
GLUD2
resolver
genesymbol_syn
GLUDP1
resolver
hgnc
HGNC:4336
resolver
uniprot
A0A140VK14
resolver
uniprot
B2R8G0
resolver
uniprot
Q9UDQ4
resolver
uniprot_entry
A0A140VK14_HUMAN
resolver
uniprot_entry
DHE4_HUMAN
resolver
uniprot_sec
B2R8G0
resolver
uniprot_sec
Q9UDQ4
resolver
activity_regulation
ACTIVITY REGULATION: Allosterically activated by L-leucine and ADP. Unlike the housekeeping GLUD1 paralog, GLUD2 is insensitive to GTP inhibition. {ECO:0000269|PubMed:11032875}.
uniprot
proteins
amino_acid_sequence
MYRYLAKALLPSRAGPAALGSAANHSAALLGRGRGQPAAASQPGLALAARRHYSELVADREDDPNFFKMVEGFFDRGASIVEDKLVKDLRTQESEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTENELEKITRRFTMELAKKGFIGPGVDVPAPDMNTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFRDKTFVVQGFGNVGLHSMRYLHRFGAKCIAVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKPYEGSILEVDCDILIPAATEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNILVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLLSVQESLERKFGKHGGTIPIVPTAEFQDSISGASEKDIVHSALAYTMERSARQIMHTAMKYNLGLDLRTAAYVNAIEKVFKVYSEAGVTFT
uniprot
proteins
ec_number
1.4.1.3
uniprot
proteins
function
FUNCTION: Catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia (PubMed:11032875). Plays a key role in glutamate metabolism and energy production via the TCA cycle in neural and testicular tissues (PubMed:11032875). Important for recycling glutamate during neurotransmission (By similarity). {ECO:0000250|UniProtKB:Q64HZ9, ECO:0000269|PubMed:11032875}.
uniprot
proteins
mass_dalton
61434
uniprot
proteins
post_translational_modification
PTM: Stoichiometry shows that ADP-ribosylation occurs in one subunit per catalytically active homohexamer. {ECO:0000269|PubMed:16023112}.
uniprot
proteins
protein_family
Glu/Leu/Phe/Val dehydrogenases family
uniprot
proteins
pubmed
11032875
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
16023112
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22709669
uniprot
proteins
pubmed
33421122
uniprot
proteins
pubmed
8207021
uniprot
proteins
sequence_length
558
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:22709669}.
uniprot
proteins