Celf1
entrez
362160
canonical
uniprot
Q4QQT3
canonical
ensembl
ENSRNOG00000010379
resolver
ensp
ENSRNOP00000014484
resolver
ensp
ENSRNOP00000080849
resolver
ensp
ENSRNOP00000094511
resolver
ensp
ENSRNOP00000111254
resolver
enst
ENSRNOT00000014484
resolver
enst
ENSRNOT00000106910
resolver
enst
ENSRNOT00000109347
resolver
enst
ENSRNOT00000151133
resolver
genesymbol
Celf1
resolver
genesymbol_syn
Cugbp1
resolver
uniprot
A0A8I6AL51
resolver
uniprot
A0A8L2Q6U8
resolver
uniprot
A0ABK0LK04
resolver
uniprot_entry
A0A8I6AL51_RAT
resolver
uniprot_entry
A0A8L2Q6U8_RAT
resolver
uniprot_entry
A0ABK0LK04_RAT
resolver
uniprot_entry
CELF1_RAT
resolver
amino_acid_sequence
MNGTLDHPDQPDLDAIKMFVGQVPRTWSEKDLRELFEQYGAVYEINILRDRSQNPPQSKGCCFVTFYTRKAALEAQNALHNMKVLPGMHHPIQMKPADSEKNNAVEDRKLFIGMISKKCTENDIRVMFSSFGQIEECRILRGPDGLSRGCAFVTFTTRTMAQTAIKAMHQAQTMEGCSSPMVVKFADTQKDKEQKRMAQQLQQQMQQISAASVWGNLAGLNTLGPQYLALYLQLLQQTANSGNLNTLSSLHPMGGLNAMQLQNLAALAAAASAAQNTPSGTNALTTSSSPLSVLTSSAGSSPSSSSSNSVNPIASLGALQTLAGATAGLNVGSLAGMAALNGGLGSSGLSNGTGSTMEALTQAYSGIQQYAAAALPTLYNQNLLTQQSIGAAGSQKEGPEGANLFIYHLPQEFGDQDLLQMFMPFGNVVSAKVFIDKQTNLSKCFGFVSYDNPVSAQAAIQSMNGFQIGMKRLKVQLKRSKNDSKPY
uniprot
proteins
function
FUNCTION: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts both as an activator and as a repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB. Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPB mRNA. Increases mRNA translation of CEBPB in aging liver. Increases translation of CDKN1A mRNA by antagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylase PARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion of spermatogenesis. Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and to Bruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region of CEBPB mRNA in aging liver (By similarity). May be a specific regulator of miRNA biogenesis. Binds to primary microRNA pri-MIR140 and, with CELF2, negatively regulates the processing to mature miRNA (By similarity). {ECO:0000250|UniProtKB:P28659, ECO:0000250|UniProtKB:Q92879}.
uniprot
proteins
mass_dalton
52205
uniprot
proteins
protein_family
CELF/BRUNOL family
uniprot
proteins
pubmed
10536163
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
487
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=RNA-binding activity is detected in both nuclear and cytoplasmic compartments. {ECO:0000250}.
uniprot
proteins