Mvk
entrez
81727
canonical
uniprot
P17256
canonical
ensembl
ENSRNOG00000049604
resolver
ensp
ENSRNOP00000077122
resolver
genesymbol
Mvk
resolver
uniprot_entry
KIME_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Farnesyl pyrophosphate and geranyl pyrophosphate inhibit mevalonate kinase activity by binding competitively at the ATP-binding sites. {ECO:0000250|UniProtKB:Q03426}.
uniprot
proteins
amino_acid_sequence
MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLVLRPQSNGKVSLNLPNVGIKQVWDVATLQLLDTGFLEQGDVPAPTLEQLEKLKKVAGLPRDCVGNEGLSLLAFLYLYLAICRKQRTLPSLDIMVWSELPPGAGLGSSAAYSVCVAAALLTACEEVTNPLKDRGSIGSWPEEDLKSINKWAYEGERVIHGNPSGVDNSVSTWGGALRYQQGKMSSLKRLPALQILLTNTKVPRSTKALVAGVRSRLIKFPEIMAPLLTSIDAISLECERVLGEMAAAPVPEQYLVLEELMDMNQHHLNALGVGHASLDQLCQVTAAHGLHSKLTGAGGGGCGITLLKPGLERAKVEAAKQALTGCGFDCWETSIGAPGVSMHSATSIEDPVRQALGL
uniprot
proteins
ec_number
2.7.1.36
uniprot
proteins
function
FUNCTION: Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis. {ECO:0000250|UniProtKB:Q03426}.
uniprot
proteins
mass_dalton
41988
uniprot
proteins
mutagenesis
MUTAGEN 20; /note="H->K: Induce significant secondary structural change."; /evidence="ECO:0000269|PubMed:14680942"; MUTAGEN 20; /note="H->L,Y: Approximately 5-fold decrease in Vmax for (R,S)-mevalonate. Approximately 3-fold increase in KM for (R,S)-mevalonate."; /evidence="ECO:0000269|PubMed:14680942
uniprot
proteins
pathway_participation
PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3. {ECO:0000305}.
uniprot
proteins
protein_family
GHMP kinase family
uniprot
proteins
protein_family
Mevalonate kinase subfamily
uniprot
proteins
pubmed
11877411
uniprot
proteins
pubmed
1312092
uniprot
proteins
pubmed
14680942
uniprot
proteins
pubmed
14730012
uniprot
proteins
pubmed
18302342
uniprot
proteins
pubmed
2158094
uniprot
proteins
sequence_length
395
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14730012}. Peroxisome {ECO:0000269|PubMed:1312092}.
uniprot
proteins