SEM1
entrez
7979
canonical
uniprot
P60896
canonical
ensembl
ENSG00000127922
resolver
ensp
ENSP00000248566
resolver
ensp
ENSP00000392852
resolver
ensp
ENSP00000409481
resolver
ensp
ENSP00000416322
resolver
ensp
ENSP00000482085
resolver
ensp
ENSP00000485341
resolver
ensp
ENSP00000485353
resolver
ensp
ENSP00000662209
resolver
ensp
ENSP00000722965
resolver
ensp
ENSP00000773209
resolver
ensp
ENSP00000773217
resolver
ensp
ENSP00000773221
resolver
enst
ENST00000248566
resolver
enst
ENST00000413065
resolver
enst
ENST00000417009
resolver
enst
ENST00000449279
resolver
enst
ENST00000613919
resolver
enst
ENST00000623498
resolver
enst
ENST00000623693
resolver
genesymbol
SEM1
resolver
genesymbol
SHFM1
resolver
genesymbol_syn
C7orf76
resolver
genesymbol_syn
DSS1
resolver
genesymbol_syn
SHFDG1
resolver
genesymbol_syn
SHFM1
resolver
hgnc
HGNC:10845
resolver
uniprot
A0A087WYU0
resolver
uniprot
A0A096LP17
resolver
uniprot
A0A096LP28
resolver
uniprot
F2Z2N6
resolver
uniprot
F2Z309
resolver
uniprot
Q13437
resolver
uniprot
Q61067
resolver
uniprot
Q6IBB7
resolver
uniprot_entry
A0A087WYU0_HUMAN
resolver
uniprot_entry
A0A096LP17_HUMAN
resolver
uniprot_entry
A0A096LP28_HUMAN
resolver
uniprot_entry
F2Z2N6_HUMAN
resolver
uniprot_entry
F2Z309_HUMAN
resolver
uniprot_entry
Q6IBB7_HUMAN
resolver
uniprot_entry
SEM1_HUMAN
resolver
uniprot_sec
Q13437
resolver
uniprot_sec
Q61067
resolver
amino_acid_sequence
MSEKKQPVDLGLLEEDDEFEEFPAEDWAGLDEDEDAHVWEDNWDDDNVEDDFSNQLRAELEKHGYKMETS
uniprot
proteins
function
FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair (PubMed:15117943). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability. R-loop accumulation increases in SEM1-depleted cells. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:15117943, ECO:0000269|PubMed:22307388, ECO:0000269|PubMed:24896180}.
uniprot
proteins
mass_dalton
8278
uniprot
proteins
protein_family
DSS1/SEM1 family
uniprot
proteins
pubmed
10373512
uniprot
proteins
pubmed
12228710
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
1317798
uniprot
proteins
pubmed
15117943
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17323924
uniprot
proteins
pubmed
21719596
uniprot
proteins
pubmed
22307388
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24896180
uniprot
proteins
pubmed
26833090
uniprot
proteins
pubmed
27342858
uniprot
proteins
pubmed
27428775
uniprot
proteins
pubmed
8733122
uniprot
proteins
sequence_length
70
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26833090}.
uniprot
proteins