SMG7
entrez
9887
canonical
uniprot
Q92540
canonical
ensembl
ENSG00000116698
resolver
ensp
ENSP00000340766
resolver
ensp
ENSP00000356507
resolver
ensp
ENSP00000421358
resolver
ensp
ENSP00000425133
resolver
ensp
ENSP00000426915
resolver
ensp
ENSP00000508915
resolver
ensp
ENSP00000510175
resolver
ensp
ENSP00000573658
resolver
ensp
ENSP00000590547
resolver
ensp
ENSP00000710342
resolver
enst
ENST00000367537
resolver
enst
ENST00000685780
resolver
enst
ENST00000688051
resolver
genesymbol
SGA56M
resolver
genesymbol
SMG7
resolver
genesymbol_syn
C1orf16
resolver
genesymbol_syn
EST1C
resolver
genesymbol_syn
KIAA0250
resolver
genesymbol_syn
SMG7
resolver
hgnc
HGNC:16792
resolver
uniprot
A0A8I5KSL3
resolver
uniprot
A0A8I5KYV3
resolver
uniprot
B4DRB2
resolver
uniprot
E9PCI0
resolver
uniprot
E9PD50
resolver
uniprot
E9PEH2
resolver
uniprot
Q5T1Q0
resolver
uniprot
Q6PIE0
resolver
uniprot
Q6TV06
resolver
uniprot
Q7Z7H9
resolver
uniprot
Q8IXC1
resolver
uniprot
Q8IXC2
resolver
uniprot_entry
A0A8I5KSL3_HUMAN
resolver
uniprot_entry
A0A8I5KYV3_HUMAN
resolver
uniprot_entry
E9PD50_HUMAN
resolver
uniprot_entry
Q6TV06_HUMAN
resolver
uniprot_entry
SMG7_HUMAN
resolver
uniprot_sec
B4DRB2
resolver
uniprot_sec
E9PCI0
resolver
uniprot_sec
E9PEH2
resolver
uniprot_sec
Q5T1Q0
resolver
uniprot_sec
Q6PIE0
resolver
uniprot_sec
Q7Z7H9
resolver
uniprot_sec
Q8IXC1
resolver
uniprot_sec
Q8IXC2
resolver
amino_acid_sequence
MSLQSAQYLRQAEVLKADMTDSKLGPAEVWTSRQALQDLYQKMLVTDLEYALDKKVEQDLWNHAFKNQITTLQGQAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVFNVDLPCRVKSSQLGIISNKQTHTSAIVKPQSSSCSYICQHCLVHLGDIARYRNQTSQAESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFPFPAASTNLQKALSKALESRDEVKTKWGVSDFIKAFIKFHGHVYLSKSLEKLSPLREKLEEQFKRLLFQKAFNSQQLVHVTVINLFQLHHLRDFSNETEQHTYSQDEQLCWTQLLALFMSFLGILCKCPLQNESQEESYNAYPLPAVKVSMDWLRLRPRVFQEAVVDERQYIWPWLISLLNSFHPHEEDLSSISATPLPEEFELQGFLALRPSFRNLDFSKGHQGITGDKEGQQRRIRQQRLISIGKWIADNQPRLIQCENEVGKLLFITEIPELILEDPSEAKENLILQETSVIESLAADGSPGLKSVLSTSRNLSNNCDTGEKPVVTFKENIKTREVNRDQGRSFPPKEVRRDYSKGITVTKNDGKKDNNKRKTETKKCTLEKLQETGKQNVAVQVKSQTELRKTPVSEARKTPVTQTPTQASNSQFIPIHHPGAFPPLPSRPGFPPPTYVIPPPVAFSMGSGYTFPAGVSVPGTFLQPTAHSPAGNQVQAGKQSHIPYSQQRPSGPGPMNQGPQQSQPPSQQPLTSLPAQPTAQSTSQLQVQALTQQQQSPTKAVPALGKSPPHHSGFQQYQQADASKQLWNPPQVQGPLGKIMPVKQPYYLQTQDPIKLFEPSLQPPVMQQQPLEKKMKPFPMEPYNHNPSEVKVPEFYWDSSYSMADNRSVMAQQANIDRRGKRSPGVFRPEQDPVPRMPFEKSLLEKPSELMSHSSSFLSLTGFSLNQERYPNNSMFNEVYGKNLTSSSKAELSPSMAPQETSLYSLFEGTPWSPSLPASSDHSTPASQSPHSSNPSSLPSSPPTHNHNSVPFSNFGPIGTPDNRDRRTADRWKTDKPAMGGFGIDYLSATSSSESSWHQASTPSGTWTGHGPSMEDSSAVLMESLKSIWSSSMMHPGPSALEQLLMQQKQKQQRGQGTMNPPH
uniprot
proteins
function
FUNCTION: Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. {ECO:0000269|PubMed:15546618, ECO:0000269|PubMed:15721257}.
uniprot
proteins
mass_dalton
127282
uniprot
proteins
mutagenesis
MUTAGEN 66; /note="K->E: Abolishes interaction with UPF1; when associated with E-163."; /evidence="ECO:0000269|PubMed:15721257"; MUTAGEN 163; /note="R->E: Abolishes interaction with UPF1; when associated with E-66."; /evidence="ECO:0000269|PubMed:15721257
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
14636577
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15546618
uniprot
proteins
pubmed
15721257
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25220460
uniprot
proteins
pubmed
9039502
uniprot
proteins
sequence_length
1137
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14636577}. Nucleus {ECO:0000269|PubMed:14636577}. Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm. {ECO:0000269|PubMed:14636577}.
uniprot
proteins