Cnot4
entrez
53621
canonical
uniprot
Q8BT14
canonical
ensembl
ENSMUSG00000038784
resolver
ensp
ENSMUSP00000044137
resolver
ensp
ENSMUSP00000110640
resolver
ensp
ENSMUSP00000110645
resolver
ensp
ENSMUSP00000144352
resolver
ensp
ENSMUSP00000144409
resolver
ensp
ENSMUSP00000300150
resolver
ensp
ENSMUSP00000300168
resolver
enst
ENSMUST00000114989
resolver
enst
ENSMUST00000114993
resolver
enst
ENSMUST00000202143
resolver
genesymbol
Cnot4
resolver
genesymbol_syn
Not4
resolver
uniprot
A0A0J9YUU9
resolver
uniprot
A0A0R4J1K1
resolver
uniprot
E9QA19
resolver
uniprot
Q05BG1
resolver
uniprot
Q3TMD4
resolver
uniprot
Q8CCR4
resolver
uniprot
Q9CV74
resolver
uniprot
Q9Z1D0
resolver
uniprot_entry
A0A0J9YUU9_MOUSE
resolver
uniprot_entry
A0A0R4J1K1_MOUSE
resolver
uniprot_entry
CNOT4_MOUSE
resolver
uniprot_entry
E9QA19_MOUSE
resolver
uniprot_entry
Q05BG1_MOUSE
resolver
uniprot_entry
Q3TMD4_MOUSE
resolver
uniprot_sec
Q8CCR4
resolver
uniprot_sec
Q9CV74
resolver
uniprot_sec
Q9Z1D0
resolver
amino_acid_sequence
MSRSPDAKEDPVECPLCMEPLEIDDINFFPCTCGYQICRFCWHRIRTDENGLCPACRKPYPEDPAVYKPLSQEELQRIKNEKKQKQNERKQKISENRKHLASVRVVQKNLVFVVGLSQRLADPEVLKRPEYFGKFGKIHKVVINNSTSYAGSQGPSASAYVTYIRSEDALRAIQCVNNVVVDGRTLKASLGTTKYCSYFLKNMQCPKPDCMYLHELGDEAASFTKEEMQAGKHQEYEQKLLQELYKLNPNFLQLSTGSVDKNKNKVTPLQRYDTPIDKPSDSLSIGNGDNSQQISNSDTPSPPPGLSKSNPVIPISSSNHSARSPFEGAVTESQSLFSDNFRHPNPIPSGLPPFPSSPQTPSDWPTAPEPQSLFTSETIPVSSSTDWQAAFGFGSSKQPEDDLGFDPFDVTRKALADLIEKELSVQDQPSLSPTSLQNASSHTTTAKGPGSGFLHSAAPTNANSLNSTFSVLPQRFPQFQQHRAVYNSFGFPGQAARYPWMAFPRNSIMHLNHTANPTSNSNFLDLNLPPQHNTGLGGIPIAGEEEVKVSTMPLSASSHSLQQGQQPTSLHTTVA
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Has E3 ubiquitin ligase activity, promoting ubiquitination and degradation of target proteins. Involved in activation of the JAK/STAT pathway. Catalyzes ubiquitination of methylated RBM15. Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, upon mitochondria damage, ubiquitinates ABCE1 and thereby recruits autophagy receptors to the mitochondrial outer membrane to initiate mitophagy. {ECO:0000250|UniProtKB:O95628}.
uniprot
proteins
mass_dalton
63474
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:O95628}.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. {ECO:0000250|UniProtKB:O95628}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
575
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
uniprot
proteins