B4GALT6
entrez
9331
canonical
uniprot
Q9UBX8
canonical
ensembl
ENSG00000118276
resolver
ensp
ENSP00000237019
resolver
ensp
ENSP00000306459
resolver
ensp
ENSP00000533636
resolver
enst
ENST00000237019
resolver
genesymbol
B4GALT6
resolver
hgnc
HGNC:929
resolver
uniprot
G3XA83
resolver
uniprot
O60514
resolver
uniprot
Q59GB5
resolver
uniprot
Q6NT09
resolver
uniprot
Q8WZ95
resolver
uniprot_entry
B4GT6_HUMAN
resolver
uniprot_entry
G3XA83_HUMAN
resolver
uniprot_entry
Q59GB5_HUMAN
resolver
uniprot_entry
Q8WZ95_HUMAN
resolver
uniprot_sec
O60514
resolver
uniprot_sec
Q6NT09
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by EDTA. {ECO:0000250|UniProtKB:O88419}.
uniprot
proteins
amino_acid_sequence
MSVLRRMMRVSNRSLLAFIFFFSLSSSCLYFIYVAPGIANTYLFMVQARGIMLRENVKTIGHMIRLYTNKNSTLNGTDYPEGNNSSDYLVQTTTYLPENFTYSPYLPCPEKLPYMRGFLNVNVSEVSFDEIHQLFSKDLDIEPGGHWRPKDCKPRWKVAVLIPFRNRHEHLPIFFLHLIPMLQKQRLEFAFYVIEQTGTQPFNRAMLFNVGFKEAMKDSVWDCVIFHDVDHLPENDRNYYGCGEMPRHFAAKLDKYMYILPYKEFFGGVSGLTVEQFRKINGFPNAFWGWGGEDDDLWNRVHYAGYNVTRPEGDLGKYKSIPHHHRGEVQFLGRYKLLRYSKERQYIDGLNNLIYRPKILVDRLYTNISVNLMPELAPIEDY
uniprot
proteins
ec_number
2.4.1.-
uniprot
proteins
ec_number
2.4.1.274
uniprot
proteins
function
FUNCTION: Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (PubMed:1551920, PubMed:24498430, PubMed:3099851). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (By similarity). {ECO:0000250|UniProtKB:Q9WVK5, ECO:0000269|PubMed:1551920, ECO:0000269|PubMed:24498430, ECO:0000269|PubMed:3099851}.
uniprot
proteins
mass_dalton
44914
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation.; PATHWAY: Sphingolipid metabolism.
uniprot
proteins
protein_family
Glycosyltransferase 7 family
uniprot
proteins
pubmed
10320813
uniprot
proteins
pubmed
10580128
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1551920
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
24498430
uniprot
proteins
pubmed
3099851
uniprot
proteins
pubmed
9597550
uniprot
proteins
sequence_length
382
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:P15291}; Single-pass type II membrane protein. Note=Trans cisternae of Golgi stack. {ECO:0000250|UniProtKB:P15291}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..35; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins