Nlrp6
entrez
171390
canonical
uniprot
Q63035
canonical
ensembl
ENSRNOG00000045677
resolver
ensp
ENSRNOP00000109810
resolver
genesymbol
Nlrp6
resolver
genesymbol_syn
Nalp6
resolver
genesymbol_syn
Navr
resolver
genesymbol_syn
Pypaf5
resolver
uniprot
A5X5C9
resolver
uniprot
D3ZYC0
resolver
uniprot
F1LSH2
resolver
uniprot_entry
NLRP6_RAT
resolver
uniprot_sec
A5X5C9
resolver
uniprot_sec
D3ZYC0
resolver
uniprot_sec
F1LSH2
resolver
amino_acid_sequence
MDAAGASCSSSEAVARELLLAALQDLSQEQLKRFRHKLRDAPLDGRSIPWGRLEHSDAVDLTDKLIEFYAPEPAVDVTRKILKKADIRDVSLRLKEQQLQRLGSSSALLTVSEYKKKYREHVLRQHAKVKERNARSVKINKRFTKLLIAPGSGAGEDELLGTSGEPEPERARRSDTHTFNRLFRGNDDEGPRPLTVVLQGPAGIGKTMAAKKILYDWAGGKLYHSQVDFAFFMPCGELLERPGTRSLADLILEQCPDRTAPVRRILAQPHRLLFILDGADELPTLAAPEATPCRDPFEATSGLRVLSGLLSQELLPSARLLVTSRNATLGRLQGRLCSPQCAEVRGFSDKDKKKYFFKFFRDERKAERAYRFVKENETLYALCFVPFVCWIVCTVLLQQMELGRDLSRTSKTTTSVYLLFITSMLKSAGTNGPRVQGELRMLCRLAREGILKHQAQFSEKDLERLKLQGSQVQTMFLSKKELPGVLETVVTYQFIDQSFQEFLAALSYLLDAEGAPGNSAGSVQMLVNSDAGLRGHLALTTRFLFGLLSTERIRDIGNHFGCVVPGRVKQDTLRWVQGQSQPKVATVGAEKKDELKDEEAEEEEEEEEEEEEELNFGLELLYCLYETQEDDFVRQALSSLPEMVLERVRLTRMDLEVLSYCVQCCPDGQALRLVSCGLVAAKEKKKKKKSFMNRLKGSQSTGKQPPASLLRPLCEAMITQQCGLSILTLSHCKLPDAVCRDLSEALKVAPSLRELGLLQNRLTEAGLRLLSQGLAWPKCKVQTLRIQMPGLQEVIHYLVIVLQQSPVLTTLDLSGCQLPGTVVEPLCSALKHPKCGLKTLSLTSVELTENPLRELQAVKTLKPDLAIIHSKLGTHPQPLKG
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Nlrp6 may be a cause of salt-sensitive hypertension. {ECO:0000305|PubMed:11984003}.
uniprot
proteins
function
FUNCTION: Acts as the sensor component of the NLRP6 inflammasome, which mediates inflammasome activation in response to various pathogen-associated signals, leading to maturation and secretion of IL1B and IL18. Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation. Acts as a recognition receptor (PRR): recognizes and binds specific pathogens and other damage-associated signals, such as lipoteichoic acid (LTA), a cell-wall component of Gram-positive bacteria, or double stranded RNA (dsRNA). May also recognize and bind lipopolysaccharide (LPS), a major component of the outer membrane of Gram-negative bacteria; however, LPS is probably not a major activator of the NLRP6 inflammasome. Following LTA- or dsRNA-binding, NLRP6 undergoes liquid-liquid phase separation (LLPS), enhancing multivalent interactions, an essential step for the formation of the NLRP6 inflammasome polymeric complex. The NLRP6 inflammasome acts by promoting recruitment of effector pro-inflammatory caspases (CASP1 and/or CASP4) that catalyze maturation and secretion of IL1B and IL18 in the extracellular milieu. The NLRP6 inflammasome plays a central role in the maintenance of epithelial integrity and host defense against microbial infections in the intestine. Required to restrict infection against Gram-positive bacteria by recognizing lipoteichoic acid (LTA), leading to recruitment of CASP4 and CASP1, and subsequent maturation and secretion of IL1B and IL18. Involved in intestinal antiviral innate immunity together with DHX15: recognizes and binds viral dsRNA to restrict infection by enteric viruses through the interferon pathway and GSDMD-dependent release of IL18 (By similarity). Required to prevent infection by the apicomplexan parasite Cryptosporidium in enterocytes by promoting GSDMD-dependent release of IL18. The NLRP6 inflammasome may also regulate the gut microbiota composition by acting as a sensor of microbiota-associated metabolites to form a PYCARD/ASC-dependent inflammasome for downstream IL18 release and secretion of antimicrobial peptides. Essential for gut mucosal self-renewal and proliferation. Regulate mucus secretion in an inflammasome- and autophagy-dependent manner to prevent invasion by enteric bacteria,. During systemic bacterial infections, the NLRP6 inflammasome negatively regulates neutrophil recruitment and neutrophil extracellular traps (NETs) formation. May promote peripheral nerve recovery following injury via an inflammasome-independent mechanism (By similarity). {ECO:0000250|UniProtKB:P59044, ECO:0000250|UniProtKB:Q91WS2}.
uniprot
proteins
mass_dalton
98324
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated with 'Lys-63'-linked chains, promoting the interaction with PYCARD/ASC and formation of the NLRP6 inflammasome. Deubiquitination by CYLD decreases the interaction with PYCARD/ASC. {ECO:0000250|UniProtKB:Q91WS2}.
uniprot
proteins
protein_family
NLRP family
uniprot
proteins
pubmed
11984003
uniprot
proteins
pubmed
12633874
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
18413781
uniprot
proteins
pubmed
21088234
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7489366
uniprot
proteins
sequence_length
881
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:18413781}. Inflammasome {ECO:0000250|UniProtKB:P59044}. Cell membrane {ECO:0000269|PubMed:18413781}. Nucleus membrane {ECO:0000269|PubMed:18413781}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:18413781}. Cell membrane {ECO:0000269|PubMed:18413781}. Note=Predominantly expressed at the cell membrane.
uniprot
proteins