RNF166
entrez
115992
canonical
uniprot
Q96A37
canonical
ensembl
ENSG00000158717
resolver
ensp
ENSP00000326095
resolver
ensp
ENSP00000440454
resolver
ensp
ENSP00000446301
resolver
ensp
ENSP00000457336
resolver
ensp
ENSP00000677663
resolver
ensp
ENSP00000677667
resolver
ensp
ENSP00000713357
resolver
genesymbol
RNF166
resolver
hgnc
HGNC:28856
resolver
uniprot
B3KQ03
resolver
uniprot
D3DX75
resolver
uniprot
H3BTU8
resolver
uniprot
Q96DM0
resolver
uniprot_entry
RN166_HUMAN
resolver
uniprot_sec
B3KQ03
resolver
uniprot_sec
D3DX75
resolver
uniprot_sec
H3BTU8
resolver
uniprot_sec
Q96DM0
resolver
amino_acid_sequence
MAMFRSLVASAQQRQPPAGPAGGDSGLEAQYTCPICLEVYHRPVAIGSCGHTFCGECLQPCLQVPSPLCPLCRLPFDPKKVDKATHVEKQLSSYKAPCRGCNKKVTLAKMRVHISSCLKVQEQMANCPKFVPVVPTSQPIPSNIPNRSTFACPYCGARNLDQQELVKHCVESHRSDPNRVVCPICSAMPWGDPSYKSANFLQHLLHRHKFSYDTFVDYSIDEEAAFQAALALSLSEN
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that promotes the ubiquitination of different substrates (PubMed:27880896). In turn, participates in different biological processes including interferon production or autophagy (PubMed:26456228, PubMed:27880896). Plays a role in the activation of RNA virus-induced interferon-beta production by promoting the ubiquitination of TRAF3 and TRAF6 (PubMed:26456228). Also plays a role in the early recruitment of autophagy adapters to bacteria (PubMed:27880896). Mediates 'Lys-29' and 'Lys-33'-linked ubiquitination of SQSTM1 leading to xenophagic targeting of bacteria and inhibition of their replication (PubMed:27880896). {ECO:0000269|PubMed:26456228, ECO:0000269|PubMed:27880896}.
uniprot
proteins
mass_dalton
26122
uniprot
proteins
mutagenesis
MUTAGEN 33; /note="C->A: Complete loss of SQSTM1 ubiquitination; in association with A-36."; /evidence="ECO:0000269|PubMed:27880896"; MUTAGEN 36; /note="C->A: Complete loss of SQSTM1 ubiquitination; in association with A-33."; /evidence="ECO:0000269|PubMed:27880896
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:27880896}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
26456228
uniprot
proteins
pubmed
27880896
uniprot
proteins
sequence_length
237
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:26456228}.
uniprot
proteins