RNASEL
entrez
6041
canonical
uniprot
Q05823
canonical
ensembl
ENSG00000135828
resolver
ensp
ENSP00000356530
resolver
ensp
ENSP00000440844
resolver
ensp
ENSP00000724352
resolver
genesymbol
RNASEL
resolver
genesymbol_syn
RNS4
resolver
hgnc
HGNC:10050
resolver
uniprot
Q5W0L2
resolver
uniprot
Q6AI46
resolver
uniprot_entry
RN5A_HUMAN
resolver
uniprot_sec
Q5W0L2
resolver
uniprot_sec
Q6AI46
resolver
activity_regulation
ACTIVITY REGULATION: After binding to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) the homodimerization and subsequent activation occurs. Inhibited by RNASEL inhibitor ABCE1/RLI, a cytoplasmic member of the ATP-binding cassette (ABC) transporter family.
uniprot
proteins
amino_acid_sequence
MESRDHNNPQEGPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVGDLLKFIRNLGEHIDEEKHKKMKLKIGDPSLYFQKTFPDLVIYVYTKLQNTEYRKHFPQTHSPNKPQCDGAGGASGLASPGC
uniprot
proteins
disease_involvement
DISEASE: Prostate cancer, hereditary, 1 (HPC1) [MIM:601518]: A condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. {ECO:0000305|PubMed:11799394, ECO:0000305|PubMed:11941539, ECO:0000305|PubMed:12415269, ECO:0000305|PubMed:17344846}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.1.26.-
uniprot
proteins
function
FUNCTION: Endoribonuclease that functions in the interferon (IFN) antiviral response (PubMed:11585831, PubMed:26263979). In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes (PubMed:11585831, PubMed:26263979). RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis (PubMed:11585831, PubMed:26263979). Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances (PubMed:11585831, PubMed:26263979). In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis (PubMed:26263979). Might play a central role in the regulation of mRNA turnover (PubMed:11585831). Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length. Involved in intercellular immune signaling (PubMed:40010341). Cross-activated by 2',5'-oligoadenylates (2-5A) previously generated in RNA virus-infected cells, triggers type I interferon signaling in uninfected neighboring cells to limit local spread of infection (PubMed:40010341). {ECO:0000269|PubMed:11585831, ECO:0000269|PubMed:26263979, ECO:0000269|PubMed:40010341}.
uniprot
proteins
mass_dalton
83533
uniprot
proteins
mutagenesis
MUTAGEN 240; /note="K->N: Reduced 2-5A binding activity; almost complete loss of 2-5A binding activity; when associated with N-274."; /evidence="ECO:0000269|PubMed:7680958"; MUTAGEN 274; /note="K->N: Reduced 2-5A binding activity; almost complete loss of 2-5A binding activity; when associated with N-240."; /evidence="ECO:0000269|PubMed:7680958"; MUTAGEN 392; /note="K->R: Complete loss of enzymatic activity and enzyme dimerization. No change in binding to 2-5A and RNA."; /evidence="ECO:0000269|PubMed:9862963"; MUTAGEN 583; /note="H->A: No change in enzymatic activity."; /evidence="ECO:0000269|PubMed:11333017"; MUTAGEN 584; /note="P->A: No change in enzymatic activity."; /evidence="ECO:0000269|PubMed:11333017"; MUTAGEN 632; /note="W->A: No change in enzymatic activity."; /evidence="ECO:0000269|PubMed:11333017"; MUTAGEN 661; /note="D->A: Complete loss of enzymatic activity."; /evidence="ECO:0000269|PubMed:11333017"; MUTAGEN 667; /note="R->A: Complete loss of enzymatic activity. No change in 2-5A binding and enzyme dimerization."; /evidence="ECO:0000269|PubMed:11333017"; MUTAGEN 672; /note="H->A: Complete loss of enzymatic activity. No change in 2-5A binding activity and enzyme dimerization."; /evidence="ECO:0000269|PubMed:11333017
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11063255
uniprot
proteins
pubmed
11333017
uniprot
proteins
pubmed
11585831
uniprot
proteins
pubmed
11799394
uniprot
proteins
pubmed
11941539
uniprot
proteins
pubmed
12415269
uniprot
proteins
pubmed
15385955
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
26263979
uniprot
proteins
pubmed
36538032
uniprot
proteins
pubmed
40010341
uniprot
proteins
pubmed
7514601
uniprot
proteins
pubmed
7539425
uniprot
proteins
pubmed
7680958
uniprot
proteins
pubmed
9856285
uniprot
proteins
pubmed
9862963
uniprot
proteins
sequence_length
741
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11585831}. Mitochondrion {ECO:0000269|PubMed:11585831}.
uniprot
proteins