ACO1
entrez
48
canonical
uniprot
P21399
canonical
ensembl
ENSG00000122729
resolver
ensp
ENSP00000309477
resolver
ensp
ENSP00000369255
resolver
ensp
ENSP00000438733
resolver
ensp
ENSP00000574509
resolver
ensp
ENSP00000574510
resolver
ensp
ENSP00000574511
resolver
ensp
ENSP00000574513
resolver
ensp
ENSP00000574514
resolver
ensp
ENSP00000574515
resolver
ensp
ENSP00000574517
resolver
ensp
ENSP00000574518
resolver
ensp
ENSP00000574519
resolver
ensp
ENSP00000574520
resolver
ensp
ENSP00000574521
resolver
ensp
ENSP00000574522
resolver
ensp
ENSP00000574523
resolver
ensp
ENSP00000574524
resolver
ensp
ENSP00000633266
resolver
ensp
ENSP00000633268
resolver
ensp
ENSP00000633269
resolver
ensp
ENSP00000633270
resolver
ensp
ENSP00000633271
resolver
ensp
ENSP00000633272
resolver
ensp
ENSP00000633273
resolver
enst
ENST00000309951
resolver
enst
ENST00000379923
resolver
enst
ENST00000541043
resolver
enst
ENST00000904450
resolver
enst
ENST00000904451
resolver
enst
ENST00000904452
resolver
enst
ENST00000904454
resolver
enst
ENST00000904455
resolver
enst
ENST00000904456
resolver
enst
ENST00000904458
resolver
enst
ENST00000904459
resolver
enst
ENST00000904460
resolver
enst
ENST00000904461
resolver
enst
ENST00000904462
resolver
enst
ENST00000904463
resolver
enst
ENST00000904464
resolver
enst
ENST00000904465
resolver
enst
ENST00000963207
resolver
enst
ENST00000963209
resolver
enst
ENST00000963210
resolver
enst
ENST00000963211
resolver
enst
ENST00000963212
resolver
enst
ENST00000963213
resolver
enst
ENST00000963214
resolver
genesymbol
ACO1
resolver
genesymbol
HEL60
resolver
genesymbol
IRP1
resolver
genesymbol_syn
IREB1
resolver
hgnc
HGNC:117
resolver
uniprot
D3DRK7
resolver
uniprot
Q14652
resolver
uniprot
Q5VZA7
resolver
uniprot
Q9HBB2
resolver
uniprot
V9HWB7
resolver
uniprot_entry
ACOHC_HUMAN
resolver
uniprot_entry
Q9HBB2_HUMAN
resolver
uniprot_entry
V9HWB7_HUMAN
resolver
uniprot_sec
D3DRK7
resolver
uniprot_sec
Q14652
resolver
uniprot_sec
Q5VZA7
resolver
amino_acid_sequence
MSNPFAHLAEPLDPVQPGKKFFNLNKLEDSRYGRLPFSIRVLLEAAIRNCDEFLVKKQDIENILHWNVTQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGDPEKINPVCPADLVIDHSIQVDFNRRADSLQKNQDLEFERNRERFEFLKWGSQAFHNMRIIPPGSGIIHQVNLEYLARVVFDQDGYYYPDSLVGTDSHTTMIDGLGILGWGVGGIEAEAVMLGQPISMVLPQVIGYRLMGKPHPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDEVSITYLVQTGRDEEKLKYIKKYLQAVGMFRDFNDPSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVAVSDMKKDFESCLGAKQGFKGFQVAPEHHNDHKTFIYDNTEFTLAHGSVVIAAITSCTNTSNPSVMLGAGLLAKKAVDAGLNVMPYIKTSLSPGSGVVTYYLQESGVMPYLSQLGFDVVGYGCMTCIGNSGPLPEPVVEAITQGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTIRIDFEKEPLGVNAKGQQVFLKDIWPTRDEIQAVERQYVIPGMFKEVYQKIETVNESWNALATPSDKLFFWNSKSTYIKSPPFFENLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPREFNSYGSRRGNDAVMARGTFANIRLLNRFLNKQAPQTIHLPSGEILDVFDAAERYQQAGLPLIVLAGKEYGAGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGENADALGLTGQERYTIIIPENLKPQMKVQVKLDTGKTFQAVMRFDTDVELTYFLNGGILNYMIRKMAK
uniprot
proteins
ec_number
4.2.1.3
uniprot
proteins
function
FUNCTION: Bifunctional iron sensor that switches between 2 activities depending on iron availability (PubMed:1281544, PubMed:1946430, PubMed:8041788). Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization (PubMed:1281544, PubMed:1946430, PubMed:23891004, PubMed:8041788). Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA (PubMed:1281544, PubMed:1946430, PubMed:23891004, PubMed:8041788). {ECO:0000269|PubMed:1281544, ECO:0000269|PubMed:1946430, ECO:0000269|PubMed:23891004, ECO:0000269|PubMed:8041788}.; FUNCTION: Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate. {ECO:0000269|PubMed:1281544, ECO:0000269|PubMed:1946430, ECO:0000269|PubMed:8041788}.
uniprot
proteins
mass_dalton
98399
uniprot
proteins
mutagenesis
MUTAGEN 300; /note="C->S: No effect on aconitase activity or on RNA binding."; /evidence="ECO:0000269|PubMed:8041788"; MUTAGEN 437; /note="C->S: Loss of aconitase activity. Leads to constitutive RNA binding, irrespective of iron levels."; /evidence="ECO:0000269|PubMed:8041788"; MUTAGEN 503; /note="C->S: Loss of aconitase activity. Leads to constitutive RNA binding, irrespective of iron levels."; /evidence="ECO:0000269|PubMed:8041788"; MUTAGEN 506; /note="C->S: Loss of aconitase activity. Leads to constitutive RNA binding, irrespective of iron levels."; /evidence="ECO:0000269|PubMed:8041788"; MUTAGEN 536; /note="R->Q: Strongly reduced RNA binding."; /evidence="ECO:0000269|PubMed:8041788"; MUTAGEN 541; /note="R->Q: Strongly reduced RNA binding."; /evidence="ECO:0000269|PubMed:8041788"; MUTAGEN 699; /note="R->K: No effect on RNA binding."; /evidence="ECO:0000269|PubMed:8041788"; MUTAGEN 778; /note="S->A: No effect on iron-regulated RNA binding. Loss of aconitase activity."; /evidence="ECO:0000269|PubMed:8041788"; MUTAGEN 780; /note="R->Q: Nearly abolishes RNA binding."; /evidence="ECO:0000269|PubMed:8041788
uniprot
proteins
protein_family
Aconitase/IPM isomerase family
uniprot
proteins
pubmed
1281544
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16407072
uniprot
proteins
pubmed
1738601
uniprot
proteins
pubmed
1903202
uniprot
proteins
pubmed
1946430
uniprot
proteins
pubmed
19762596
uniprot
proteins
pubmed
19762597
uniprot
proteins
pubmed
20053667
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2172968
uniprot
proteins
pubmed
23033978
uniprot
proteins
pubmed
23891004
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29320706
uniprot
proteins
pubmed
8041788
uniprot
proteins
sequence_length
889
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:1281544}.
uniprot
proteins