Klrg1
entrez
50928
canonical
uniprot
O88713
canonical
ensembl
ENSMUSG00000030114
resolver
ensp
ENSMUSP00000032207
resolver
enst
ENSMUST00000032207
resolver
genesymbol
Klrg1
resolver
genesymbol_syn
Mafa
resolver
uniprot
Q3T1F0
resolver
uniprot_entry
KLRG1_MOUSE
resolver
uniprot_sec
Q3T1F0
resolver
amino_acid_sequence
MADSSIYSTLELPEAPQVQDESRWKLKAVLHRPHLSRFAMVALGLLTVILMSLLMYQRILCCGSKDSTCSHCPSCPILWTRNGSHCYYFSMEKKDWNSSLKFCADKGSHLLTFPDNQGVKLFGEYLGQDFYWIGLRNIDGWRWEGGPALSLRILTNSLIQRCGAIHRNGLQASSCEVALQWICKKVLY
uniprot
proteins
function
FUNCTION: Plays an inhibitory role on natural killer (NK) cells and T-cell functions upon binding to their non-MHC ligands. May mediate missing self recognition by binding to a highly conserved site on classical cadherins, enabling it to monitor expression of E-cadherin/CDH1, N-cadherin/CDH2 and R-cadherin/CDH4 on target cells. {ECO:0000269|PubMed:19604491}.
uniprot
proteins
mass_dalton
21396
uniprot
proteins
mutagenesis
MUTAGEN 5; /note="S->A: Decreases association with PTPN11."; /evidence="ECO:0000269|PubMed:17307799"; MUTAGEN 7; /note="Y->F: Abolishes the formation of KLRG1/PTPN11 and KLRG1/INPP5D."; /evidence="ECO:0000269|PubMed:17307799"; MUTAGEN 8; /note="S->A: Enhances association with PTPN11."; /evidence="ECO:0000269|PubMed:17307799"; MUTAGEN 10; /note="L->A: Abrogates completely INPP5D recruitment."; /evidence="ECO:0000269|PubMed:17307799
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in response to monoclonal antibody G63 binding and antigenic stimulation. {ECO:0000250}.
uniprot
proteins
pubmed
11220622
uniprot
proteins
pubmed
11673487
uniprot
proteins
pubmed
11884419
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16424155
uniprot
proteins
pubmed
17307799
uniprot
proteins
pubmed
19604491
uniprot
proteins
pubmed
9862378
uniprot
proteins
pubmed
9862665
uniprot
proteins
sequence_length
188
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19604491}; Single-pass type II membrane protein {ECO:0000269|PubMed:19604491}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..56; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins