SOCS4
entrez
122809
canonical
uniprot
Q8WXH5
canonical
ensembl
ENSG00000180008
resolver
ensp
ENSP00000341327
resolver
ensp
ENSP00000378855
resolver
ensp
ENSP00000452522
resolver
ensp
ENSP00000561331
resolver
ensp
ENSP00000561332
resolver
ensp
ENSP00000561333
resolver
ensp
ENSP00000561334
resolver
ensp
ENSP00000561335
resolver
ensp
ENSP00000592141
resolver
ensp
ENSP00000592142
resolver
ensp
ENSP00000592143
resolver
ensp
ENSP00000592144
resolver
enst
ENST00000339298
resolver
enst
ENST00000395472
resolver
enst
ENST00000555846
resolver
enst
ENST00000891272
resolver
enst
ENST00000891273
resolver
enst
ENST00000891274
resolver
enst
ENST00000891275
resolver
enst
ENST00000891276
resolver
enst
ENST00000922082
resolver
enst
ENST00000922083
resolver
enst
ENST00000922084
resolver
enst
ENST00000922085
resolver
genesymbol
SOCS4
resolver
genesymbol_syn
SOCS7
resolver
hgnc
HGNC:19392
resolver
uniprot_entry
SOCS4_HUMAN
resolver
amino_acid_sequence
MAENNENISKNVDVRPKTSRSRSADRKDGYVWSGKKLSWSKKSESYSDAETVNGIEKTEVSLRNQERKHSCSSIELDLDHSCGHRFLGRSLKQKLQDAVGQCFPIKNCSSRHSSGLPSKRKIHISELMLDKCPFPPRSDLAFRWHFIKRHTAPINSKSDEWVSTDLSQTELRDGQLKRRNMEENINCFSHTNVQPCVITTDNALCREGPMTGSVMNLVSNNSIEDSDMDSDDEILTLCTSSRKRNKPKWDLDDEILQLETPPKYHTQIDYVHCLVPDLLQINNNPCYWGVMDKYAAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPDITGLLEHYKDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICNCTTYDGIDALPIPSSMKLYLKEYHYKSKVRVLRIDAPEQQC
uniprot
proteins
function
FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR. {ECO:0000269|PubMed:15590694, ECO:0000269|PubMed:17997974}.
uniprot
proteins
mass_dalton
50623
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15590694
uniprot
proteins
pubmed
17997974
uniprot
proteins
sequence_length
440
uniprot
proteins