Igf2bp3
entrez
140488
canonical
uniprot
Q9CPN8
canonical
ensembl
ENSMUSG00000029814
resolver
ensp
ENSMUSP00000031838
resolver
enst
ENSMUST00000031838
resolver
genesymbol
Igf2bp3
resolver
genesymbol_syn
Vickz3
resolver
uniprot
Q3UHZ6
resolver
uniprot
Q8C2J9
resolver
uniprot_entry
IF2B3_MOUSE
resolver
uniprot_sec
Q3UHZ6
resolver
uniprot_sec
Q8C2J9
resolver
amino_acid_sequence
MNKLYIGNLSDHAGPADLESVFKDAKIPVAGPFLVKTGYAFVDCPDEGWALKAIEALSGKMELHGKPMEVEHSVPKRQRIRKLQIRNIPPHLQWEVLDSLLVQYGVVESCEQVNTDSETAVVNVTYSSKDQARQALDKLNGFQLENFTLKVAYIPDETAAQQNPSPQLRGRRGPGQRGSSRQASPGSVSKQKPCDLPLRLLVPTQFVGAIIGKEGATIRNITKQTQSKIDVHRKENTGAAEKSITILSTPEGTSAACKSILEIMHKEAQDIKFTEEIPLKILAHNNFVGRLIGKEGRNLKKIEQDTDTKITISPLQELTLYNPERTITVKGSVETCAKAEEEIMKKIRESYENDIASMNLQAHLIPGLNLNALGLFPPTSGMPPPTSGPPSTLTPPYPQFEQSETETVHLFIPALSVGAIIGKQGQHIKQLSRFAGASIKIAPAEAPDAKVRMVIITGPPEAQFKAQGRIYGKIKEENFVSPKEEVKLEAHIRVPSFAAGRVIGKGGKTVNELQSLSSAEVVVPRDQTPDENDQVVVKITGHFYACQVAQRKIQEILTQVKQHQQQKALQSGPPQSRRK
uniprot
proteins
function
FUNCTION: RNA-binding factor that may recruit target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation. Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (By similarity). Binds to the 3'-UTR of CD44 mRNA and stabilizes it, hence promotes cell adhesion and invadopodia formation (By similarity). Binds to beta-actin/ACTB and MYC transcripts (By similarity). Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. {ECO:0000250|UniProtKB:O00425, ECO:0000269|PubMed:15753088}.
uniprot
proteins
mass_dalton
63575
uniprot
proteins
mutagenesis
MUTAGEN 184; /note="S->A: Abolished phosphorylation by MTOR."; /evidence="ECO:0000269|PubMed:23388827
uniprot
proteins
protein_family
RRM IMP/VICKZ family
uniprot
proteins
pubmed
10525192
uniprot
proteins
pubmed
10875929
uniprot
proteins
pubmed
11288142
uniprot
proteins
pubmed
12161597
uniprot
proteins
pubmed
12921532
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15601260
uniprot
proteins
pubmed
15753088
uniprot
proteins
pubmed
16049158
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23388827
uniprot
proteins
pubmed
9891060
uniprot
proteins
sequence_length
579
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11288142, ECO:0000269|PubMed:12921532}. Cytoplasm {ECO:0000250}. Cytoplasm, P-body {ECO:0000250|UniProtKB:O00425}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:O00425}. Note=Found in lamellipodia of the leading edge, in the perinuclear region, and beneath the plasma membrane. The subcytoplasmic localization is cell specific and regulated by cell contact and growth. Localized at the connecting piece and the tail of the spermatozoa. In response to cellular stress, such as oxidative stress, recruited to stress granules. {ECO:0000250}.
uniprot
proteins