Fbxo41
entrez
330369
canonical
uniprot
Q6NS60
canonical
ensembl
ENSMUSG00000047013
resolver
ensp
ENSMUSP00000124524
resolver
ensp
ENSMUSP00000124754
resolver
ensp
ENSMUSP00000125671
resolver
enst
ENSMUST00000159062
resolver
enst
ENSMUST00000161078
resolver
enst
ENSMUST00000161546
resolver
genesymbol
Fbxo41
resolver
genesymbol_syn
D6Ertd538e
resolver
genesymbol_syn
Kiaa1940
resolver
uniprot
Q3UGY7
resolver
uniprot
Q6P7W4
resolver
uniprot
Q6ZPG1
resolver
uniprot_entry
FBX41_MOUSE
resolver
uniprot_entry
Q3UGY7_MOUSE
resolver
uniprot_sec
Q6P7W4
resolver
uniprot_sec
Q6ZPG1
resolver
amino_acid_sequence
MASLDLPYRCPRCGEHKRFRSLSSLRAHLEYSHTYETLYILSKTNSICDGAAAAAAAAAAASGFPLAPEPAALLAVPGARREVFESTSFQGKEQATGPSPAGPHLLHHHHHHAPLAHFPADLVPASLPCEELAEPGLVPAARYALREIEIPLGELFARKSVASSACSTPPPGPGPGPCSGPSSASPASPSPADVAYEEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEELEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLRLQQFIEELLERADRAERQLQVISSSCGSTPSASLGRGGGGSASGPGVRGPGRMREHHAGSAVPSTYAVSRHGSSPSTGASSRVPAASQSSGCYDSDSLELPRPEEGPSEDSGPGGLGSRAQATNGGSERSQAPRSSGLRRQAIQNWQRRPRRHSTEGEEGDVSDVGSRTTESEAEGPSDVPRPGPAVAGPLNSCRLSARPEGGSGRGRRVERGSPSRSNEVISPEILKMRAALFCIFTYLDTRTLLHAAEVCRDWRFVARHPAVWTRVLLENARVCSKFLAMLAQWCTQAHSLTLQNLKPRQRGKKESKEEYARSTRGCLEAGLESLLKAAGGNLLILRISHCPNILTDRSLWLASCYCRALQAVTYRSATDPVGHEVIWALGAGCRDIVSLQVAPLHPCQQPTRFSNRCLQMIGRCWPHLRALGVGGAGCGVQGLASLARNCMRLQVLELDHVSEITQEVAAEVCREGLKGLEMLVLTATPVTPKALLHFNSICRNLKSIVVQIGIADYFKEPSSPEAQKLFEDMVTKLQALRRRPGFSKILHIKVEGGC
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (PubMed:31160656). Required in the developing brain for neuronal migration and long-term cerebellar integrity (PubMed:26063905). Regulates postnatal hippocampal development, synaptic vesicle release probability at excitatory synapses and readily releasable pool size at inhibitory synapses (PubMed:35372812). Upon accumulation at the centriole, promotes disassembly of primary cilia and negatively regulates Sonic hedgehog signaling (PubMed:31160656). {ECO:0000269|PubMed:26063905, ECO:0000269|PubMed:31160656, ECO:0000269|PubMed:35372812}.
uniprot
proteins
mass_dalton
94331
uniprot
proteins
mutagenesis
MUTAGEN 577; /note="W->A: Loss of interaction with SKP1 and CUL1 and loss of centrosomal targeting."; /evidence="ECO:0000269|PubMed:31160656
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
26063905
uniprot
proteins
pubmed
31160656
uniprot
proteins
pubmed
35372812
uniprot
proteins
sequence_length
873
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:26063905, ECO:0000269|PubMed:31160656}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:26063905, ECO:0000269|PubMed:31160656}. Note=Centriolar targeting requires both the coiled-coil and F-box domains. {ECO:0000269|PubMed:31160656}.
uniprot
proteins