Tacr1
entrez
21336
canonical
uniprot
P30548
canonical
ensembl
ENSMUSG00000030043
resolver
ensp
ENSMUSP00000032122
resolver
ensp
ENSMUSP00000145217
resolver
ensp
ENSMUSP00000176607
resolver
enst
ENSMUST00000032122
resolver
enst
ENSMUST00000203775
resolver
genesymbol
Tacr1
resolver
genesymbol_syn
Tac1r
resolver
uniprot
Q8BYR7
resolver
uniprot_entry
NK1R_MOUSE
resolver
uniprot_sec
Q8BYR7
resolver
amino_acid_sequence
MDNVLPVDSDLFPNTSTNTSESNQFVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQSSVYKVSRLETTISTVVGAHEDEPEEGPKATPSSLDLTSNGSSRSNSKTMTESSSFYSNMLA
uniprot
proteins
function
FUNCTION: This is a receptor for the tachykinin neuropeptide substance P (PubMed:1370937). Is also able to bind and respond to tachynins neurokinin A/substance K and neurokinin B/neuromedin-K. The rank order of affinity of this receptor to tachykinins is: substance P > neurokinin A/substance K > neurokinin B/neuromedin-K. Substance P binding to its receptor triggers G protein-coupled receptor signaling via activation of phosphatidylinositol hydrolysis by phospholipase C. Substance P binding also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP) (By similarity). {ECO:0000250|UniProtKB:P14600, ECO:0000250|UniProtKB:P25103, ECO:0000269|PubMed:1370937}.
uniprot
proteins
mass_dalton
46322
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
1370937
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
8120392
uniprot
proteins
sequence_length
407
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P14600}; Multi-pass membrane protein {ECO:0000255}. Early endosome {ECO:0000250|UniProtKB:P14600}. Note=After signaling cascade initiation, substance P binding results in receptor internalization and localization to early endosomes, followed by receptor recycling to the cell surface. {ECO:0000250|UniProtKB:P14600}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..54; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 65..86; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 107..128; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 149..169; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 195..219; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 249..270; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 284..308; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins