RING1
entrez
6015
canonical
uniprot
Q06587
canonical
ensembl
ENSG00000204227
resolver
ensembl
ENSG00000206287
resolver
ensembl
ENSG00000226788
resolver
ensembl
ENSG00000228520
resolver
ensembl
ENSG00000231115
resolver
ensembl
ENSG00000235107
resolver
ensp
ENSP00000363787
resolver
genesymbol
RING1
resolver
genesymbol_syn
RING1A
resolver
genesymbol_syn
RNF1
resolver
hgnc
HGNC:10018
resolver
uniprot
A8JZZ0
resolver
uniprot
Q5JP96
resolver
uniprot
Q5SQW2
resolver
uniprot
Q86V19
resolver
uniprot_entry
RING1_HUMAN
resolver
uniprot_sec
A8JZZ0
resolver
uniprot_sec
Q5JP96
resolver
uniprot_sec
Q5SQW2
resolver
uniprot_sec
Q86V19
resolver
amino_acid_sequence
MTTPANAQNASKTWELSLYELHRTPQEAIMDGTEIAVSPRSLHSELMCPICLDMLKNTMTTKECLHRFCSDCIVTALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSREEYEAHQDRVLIRLSRLHNQQALSSSIEEGLRMQAMHRAQRVRRPIPGSDQTTTMSGGEGEPGEGEGDGEDVSSDSAPDSAPGPAPKRPRGGGAGGSSVGTGGGGTGGVGGGAGSEDSGDRGGTLGGGTLGPPSPPGAPSPPEPGGEIELVFRPHPLLVEKGEYCQTRYVKTTGNATVDHLSKYLALRIALERRQQQEAGEPGGPGGGASDTGGPDGCGGEGGGAGGGDGPEEPALPSLEGVSEKQYTIYIAPGGGAFTTLNGSLTLELVNEKFWKVSRPLELCYAPTKDPK
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity. {ECO:0000269|PubMed:16359901}.
uniprot
proteins
mass_dalton
42429
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
12004135
uniprot
proteins
pubmed
12167161
uniprot
proteins
pubmed
12167701
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15386022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16359901
uniprot
proteins
pubmed
16943429
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19636380
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21282530
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25725044
uniprot
proteins
pubmed
28839133
uniprot
proteins
pubmed
31839203
uniprot
proteins
pubmed
7681583
uniprot
proteins
pubmed
9199346
uniprot
proteins
pubmed
9858531
uniprot
proteins
sequence_length
406
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21282530}. Nucleus speckle {ECO:0000269|PubMed:21282530}.
uniprot
proteins