Lmbr1l
entrez
74775
canonical
uniprot
Q9D1E5
canonical
ensembl
ENSMUSG00000022999
resolver
ensp
ENSMUSP00000023736
resolver
ensp
ENSMUSP00000339800
resolver
genesymbol
Lmbr1l
resolver
genesymbol_syn
D15Ertd735e
resolver
genesymbol_syn
Kiaa1174
resolver
uniprot
Q3TD82
resolver
uniprot
Q69ZP7
resolver
uniprot_entry
LMBRL_MOUSE
resolver
uniprot_sec
Q3TD82
resolver
uniprot_sec
Q69ZP7
resolver
amino_acid_sequence
MEAADYEVLSVREQLFHDRVRECIISILLFATLYILCHIFLTRFKKPAEFTTVDDEDATVNKIALELCTFTLAVALGAVLLLPFSIISNEVLLSLPRNYYIQWLNGSLIHGLWNLVFLFSNLSLVFLMPFAYFFTESEGFAGSRKGVLGRVYETVVMLILLTLLVLGMVWVASAIVDNDKASRESLYDFWEYYLPYLYSCISFLGVLLLLVCTPLGLARMFSVTGKLLVKPRLLEDLEEQLNCSAFEEAALTRRICNPTSCWLPLDMELLHRQVLALQAQRVLLEKRRKASAWQRNLGYPLAMLCLLVLTGLSVLIVAVHILELLIDEAAMPRGMQDAALGQASFSKLGSFGAIIQVVLIFYLMVSSVVGFYSSPLFGSLRPRWHDTSMTQIIGNCVCLLVLSSALPVFSRTLGLTRFDLLGDFGRFNWLGNFYIVFLYNAAFAGLTTLCLVKTFTAAVRAELIRAFGLDRLPLPVSGFPRASRKKQHQ
uniprot
proteins
function
FUNCTION: Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (PubMed:31073040). In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (PubMed:31073040). LMBR1L stabilizes the beta-catenin destruction complex that is required for regulating CTNNB1 levels (PubMed:31073040). Acts as a LCN1 receptor and can mediate its endocytosis (By similarity). {ECO:0000250|UniProtKB:Q6UX01, ECO:0000269|PubMed:31073040}.
uniprot
proteins
mass_dalton
54958
uniprot
proteins
mutagenesis
MUTAGEN 212..489; /note="Missing: In st (strawberry phenotype); affected mice exhibit severe lymphopenia, failure of lymphocyte development, reduced natural killer (NK) cell function and impaired B-cell development."; /evidence="ECO:0000269|PubMed:31073040
uniprot
proteins
protein_family
LIMR family
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
31073040
uniprot
proteins
sequence_length
489
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:31073040}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:31073040}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 67..87; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 115..135; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 155..175; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 197..217; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 306..326; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 351..371; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 389..409; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 432..452; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins