Kpna1
entrez
16646
canonical
uniprot
Q60960
canonical
ensembl
ENSMUSG00000022905
resolver
ensp
ENSMUSP00000004054
resolver
ensp
ENSMUSP00000313412
resolver
enst
ENSMUST00000004054
resolver
genesymbol
Kpna1
resolver
genesymbol_syn
Rch2
resolver
uniprot
Q3TF32
resolver
uniprot_entry
IMA5_MOUSE
resolver
uniprot_sec
Q3TF32
resolver
amino_acid_sequence
MSTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEEVMSDGGFHEAQINNMEMAPGGVITSDMTDMIFSNSPEQQLSATQKFRKLLSKEPNPPIDEVINTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRNVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLNCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANMFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDAKIVQVALNGLENILRLGEQEAKRNGSGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDEDSSIAPQVDLSQQQYIFQQCEAPMEGFQL
uniprot
proteins
function
FUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:8631802). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:8631802). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:8631802). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin (PubMed:8631802). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:8631802). Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with and Transportin-1/TNPO1 (By similarity). {ECO:0000250|UniProtKB:P52294, ECO:0000269|PubMed:8631802}.
uniprot
proteins
mass_dalton
60183
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated in the presence of RAG1 (in vitro). {ECO:0000250|UniProtKB:P52294}.
uniprot
proteins
protein_family
Importin alpha family
uniprot
proteins
pubmed
10692581
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18716025
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27703206
uniprot
proteins
pubmed
29599122
uniprot
proteins
pubmed
8052633
uniprot
proteins
pubmed
8631802
uniprot
proteins
pubmed
9369227
uniprot
proteins
sequence_length
538
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:8631802}. Nucleus {ECO:0000305|PubMed:8631802}.
uniprot
proteins