RAB6B
entrez
51560
canonical
uniprot
Q9NRW1
canonical
ensembl
ENSG00000154917
resolver
ensp
ENSP00000285208
resolver
ensp
ENSP00000419381
resolver
genesymbol
RAB6B
resolver
hgnc
HGNC:14902
resolver
uniprot
B2R5Z9
resolver
uniprot
B7Z337
resolver
uniprot
D3DND3
resolver
uniprot
Q92929
resolver
uniprot_entry
RAB6B_HUMAN
resolver
uniprot_sec
B2R5Z9
resolver
uniprot_sec
B7Z337
resolver
uniprot_sec
D3DND3
resolver
uniprot_sec
Q92929
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. {ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MSAGGDFGNPLRKFKLVFLGEQSVGKTSLITRFMYDSFDNTYQATIGIDFLSKTMYLEDRTVRLQLWDTAGQERFRSLIPSYIRDSTVAVVVYDITNLNSFQQTSKWIDDVRTERGSDVIIMLVGNKTDLADKRQITIEEGEQRAKELSVMFIETSAKTGYNVKQLFRRVASALPGMENVQEKSKEGMIDIKLDKPQEPPASEGGCSC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (By similarity). Recruits VPS13B to the Golgi membrane (PubMed:25492866). Regulates the compacted morphology of the Golgi (PubMed:26209634). Seems to have a role in retrograde membrane traffic at the level of the Golgi complex. May function in retrograde transport in neuronal cells (PubMed:17707369). Plays a role in neuron projection development (PubMed:25492866). {ECO:0000250|UniProtKB:P20340, ECO:0000269|PubMed:17707369, ECO:0000269|PubMed:25492866, ECO:0000269|PubMed:26209634}.
uniprot
proteins
mass_dalton
23462
uniprot
proteins
mutagenesis
MUTAGEN 27; /note="T->N: Loss of APBA1-binding. Abolishes localization of VPS13B to the Golgi."; /evidence="ECO:0000269|PubMed:23737971, ECO:0000269|PubMed:25492866"; MUTAGEN 72; /note="Q->L: Interacts with APBA1. Abolishes localization of VPS13B to the Golgi."; /evidence="ECO:0000269|PubMed:23737971, ECO:0000269|PubMed:25492866
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10893188
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
16790928
uniprot
proteins
pubmed
17707369
uniprot
proteins
pubmed
18044744
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21822290
uniprot
proteins
pubmed
23737971
uniprot
proteins
pubmed
25492866
uniprot
proteins
pubmed
26209634
uniprot
proteins
pubmed
9030196
uniprot
proteins
sequence_length
208
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:17707369, ECO:0000269|PubMed:18044744, ECO:0000269|PubMed:25492866}; Lipid-anchor {ECO:0000305}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:17707369}. Cytoplasmic vesicle {ECO:0000269|PubMed:17707369}. Note=Colocalizes with BICD1 at vesicular structures that align along microtubules. {ECO:0000269|PubMed:17707369}.
uniprot
proteins