TMEM38A
entrez
79041
canonical
uniprot
Q9H6F2
canonical
ensembl
ENSG00000072954
resolver
ensp
ENSP00000187762
resolver
enst
ENST00000187762
resolver
genesymbol
TMEM38A
resolver
genesymbol_syn
TRICA
resolver
hgnc
HGNC:28462
resolver
uniprot
A8K9P9
resolver
uniprot_entry
TM38A_HUMAN
resolver
uniprot_sec
A8K9P9
resolver
activity_regulation
ACTIVITY REGULATION: Channel activity is activated by a change of voltage within the sarcoplasmic reticulum lumen and blocked by luminal high Ca(2+) levels. {ECO:0000250|UniProtKB:Q5ZK43}.
uniprot
proteins
amino_acid_sequence
MELLSALSLGELALSFSRVPLFPVFDLSYFIVSILYLKYEPGAVELSRRHPIASWLCAMLHCFGSYILADLLLGEPLIDYFSNNSSILLASAVWYLIFFCPLDLFYKCVCFLPVKLIFVAMKEVVRVRKIAVGIHHAHHHYHHGWFVMIATGWVKGSGVALMSNFEQLLRGVWKPETNEILHMSFPTKASLYGAILFTLQQTRWLPVSKASLIFIFTLFMVSCKVFLTATHSHSSPFDALEGYICPVLFGSACGGDHHHDNHGGSHSGGGPGAQHSAMPAKSKEELSEGSRKKKAKKAD
uniprot
proteins
function
FUNCTION: Intracellular monovalent cation channel required for maintenance of rapid intracellular calcium release. Acts as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores (By similarity). Opened by a change of voltage within the sarcoplasmic reticulum lumen (By similarity). {ECO:0000250|UniProtKB:A5A6S6}.
uniprot
proteins
mass_dalton
33260
uniprot
proteins
protein_family
TMEM38 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17611541
uniprot
proteins
pubmed
38556553
uniprot
proteins
sequence_length
299
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:A5A6S6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A5A6S6}. Nucleus membrane {ECO:0000250|UniProtKB:A5A6S6}.
uniprot
proteins
transmembrane_region
TRANSMEM 19..39; /note="Helical;Name=1"; /evidence="ECO:0000255"; TRANSMEM 52..72; /note="Helical;Name=2"; /evidence="ECO:0000255"; TRANSMEM 86..106; /note="Helical;Name=3"; /evidence="ECO:0000255"; TRANSMEM 145..165; /note="Helical;Name=4"; /evidence="ECO:0000255"; TRANSMEM 179..199; /note="Helical;Name=5"; /evidence="ECO:0000255"; TRANSMEM 210..230; /note="Helical;Name=6"; /evidence="ECO:0000255"; TRANSMEM 235..255; /note="Helical;Name=7"; /evidence="ECO:0000255
uniprot
proteins