BMP3
entrez
651
canonical
uniprot
P12645
canonical
ensembl
ENSG00000152785
resolver
ensp
ENSP00000282701
resolver
ensp
ENSP00000579168
resolver
enst
ENST00000282701
resolver
genesymbol
BMP3
resolver
genesymbol_syn
BMP3A
resolver
hgnc
HGNC:1070
resolver
uniprot
Q4VAS5
resolver
uniprot_entry
BMP3_HUMAN
resolver
uniprot_sec
Q4VAS5
resolver
amino_acid_sequence
MAGASRLLFLWLGCFCVSLAQGERPKPPFPELRKAVPGDRTAGGGPDSELQPQDKVSEHMLRLYDRYSTVQAARTPGSLEGGSQPWRPRLLREGNTVRSFRAAAAETLERKGLYIFNLTSLTKSENILSATLYFCIGELGNISLSCPVSGGCSHHAQRKHIQIDLSAWTLKFSRNQSQLLGHLSVDMAKSHRDIMSWLSKDITQLLRKAKENEEFLIGFNITSKGRQLPKRRLPFPEPYILVYANDAAISEPESVVSSLQGHRNFPTGTVPKWDSHIRAALSIERRKKRSTGVLLPLQNNELPGAEYQYKKDEVWEERKPYKTLQAQAPEKSKNKKKQRKGPHRKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR
uniprot
proteins
function
FUNCTION: Growth factor of the TGF-beta superfamily that plays an essential role in developmental process by inducing and patterning early skeletal formation and by negatively regulating bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentiation and ossification (PubMed:11138004, PubMed:15269709). Initiates signaling cascades by associating with type II receptor ACVR2B to activate SMAD2-dependent and SMAD-independent signaling cascades including TAK1 and JNK pathways (PubMed:31665064). {ECO:0000269|PubMed:11138004, ECO:0000269|PubMed:15269709, ECO:0000269|PubMed:31665064}.
uniprot
proteins
mass_dalton
53372
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
11138004
uniprot
proteins
pubmed
13678778
uniprot
proteins
pubmed
15269709
uniprot
proteins
pubmed
15475196
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17924656
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
31665064
uniprot
proteins
pubmed
3201241
uniprot
proteins
sequence_length
472
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins