Mafb
entrez
54264
canonical
uniprot
P54842
canonical
ensembl
ENSRNOG00055028351
resolver
ensembl
ENSRNOG00060030947
resolver
ensembl
ENSRNOG00065028719
resolver
ensp
ENSRNOP00055040371
resolver
ensp
ENSRNOP00060044594
resolver
ensp
ENSRNOP00065040674
resolver
enst
ENSRNOT00055049064
resolver
enst
ENSRNOT00060053720
resolver
enst
ENSRNOT00065049551
resolver
genesymbol
Mafb
resolver
genesymbol_syn
Maf1
resolver
uniprot_entry
MAFB_RAT
resolver
amino_acid_sequence
MAAELSMGPELPTSPLAMEYVNDFDLLKFDVKKEPLGRAERPGRPCTRLQPAGSVSSTPLSTPCSSVPSSPSFSPTEQKTHLEDLYWMASNYQQMNPEALNLTPEDAVEALIGSHPVPQPLQSFDGFRSAHHHHHHHHPHPHHGYPGAGVTHDELGPHAHPHHHHHHQASPPPSSAASPAQQLPTSHPGPGPHAAAAATAAGSNGSVEDRFSDDQLVSMSVRELNRHLRGFTKDEVIRLKQKRRTLKNRGYAQSCRYKRVQQKHHLENEKTQLIQQVEQLKQEVSRLARERDAYKVKCEKLANSGFREAGSTSDSPSSPEFFL
uniprot
proteins
function
FUNCTION: Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter. Involved either as an oncogene or as a tumor suppressor, depending on the cell context (By similarity). Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain (By similarity). {ECO:0000250|UniProtKB:P54841, ECO:0000250|UniProtKB:Q9Y5Q3}.
uniprot
proteins
mass_dalton
35792
uniprot
proteins
post_translational_modification
PTM: Sumoylated. Sumoylation on Lys-32 and Lys-297 stimulates its transcriptional repression activity and promotes macrophage differentiation from myeloid progenitors (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
protein_family
Maf subfamily
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9038383
uniprot
proteins
pubmed
9375588
uniprot
proteins
pubmed
9571165
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:9038383}.
uniprot
proteins