Nlrp14
entrez
76858
canonical
uniprot
Q6B966
canonical
ensembl
ENSMUSG00000016626
resolver
ensp
ENSMUSP00000081819
resolver
enst
ENSMUST00000084763
resolver
genesymbol
Nlrp14
resolver
genesymbol_syn
Nalp14
resolver
uniprot
B2RUL1
resolver
uniprot
Q66X14
resolver
uniprot_entry
NAL14_MOUSE
resolver
uniprot_sec
B2RUL1
resolver
uniprot_sec
Q66X14
resolver
amino_acid_sequence
MKTEDDEMEYEASKEETVSEDKDFDDGIDYRTVIKENIFTMWYKTSLHGEFATLNCVITPKDQNLLQHIFDEDIQTSEAPQTVVLQGAAGIGKTTLLKKAVLEWADGNLYQQFTHVFYLNGKEISQVKEKSFAQLISKHWPSSEGPIEQVLSKPSSLLFIIDSFDELDFSFEEPQFALCKDWTQISPVSFLISSLLRKVMLPESYLLVATRSTAWKRLVPLLQKPQRVKLSGLSKNARMDYIHHLLKDKAWATSAIYSLRMNWRLFHMCHVCHMCQMICAVLKGQVEKGGRVEETCKTSTALFTYYICSLFPRIPVGCVTLPNETLLRSLCKAAVEGIWTMKHVLYQQNLRKHELTREDILLFLDAKVLQQDTEYENCYMFTHLHVQEFFAALFYLLRENLEEQDYPSEPFENLYLLLESNHIHDPHLEQMKCFLFGLLNKDRVRQLEETFNLTISMEVREELLACLEGLEKDDSSLSQLRFQDLLHCIYETQDQEFITQALMYFQKIIVRVDEEPQLRIYSFCLKHCHTLKTMRLTARADLKNMLDTAEMCLEGAAVQVIHYWQDLFSVLHTNESLIEMDLYESRLDESLMKILNEELSHPKCKLQKLIFRAVDFLNGCQDFTFLASNKKVTHLDLKETDLGVNGLKTLCEALKCKGCKLRVLRLASCDLNVARCQKLSNALQTNRSLVFLNLSLNNLSNDGVKSLCEVLENPNSSLERLALASCGLTKAGCKVLSSALTKSKRLTHLCLSDNVLEDEGIKLLSHTLKHPQCTLQSLVLRSCSFTPIGSEHLSTALLHNRSLVHLDLGQNKLADNGVKLLCHSLQQPHCNLQELELMSCVLTSKACGDLASVLVNNSNLWSLDLGHNILDDAGLNILCDALRNPNCHVQRLGLENCGLTPGCCQDLLGILSNNKSVIQMNLMKNALDHESIKNLCKVLRSPTCKMEFLALDKKEILKKKIKKFLVDVRINNPHLVIGPECPNTESGCWWNYF
uniprot
proteins
function
FUNCTION: Component of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos (PubMed:41845018, PubMed:41917274, PubMed:41986725). They are required to store maternal proteins critical for embryonic development, such as ribosomal proteins, cytoskeletal tubulins and proteins controlling epigenetic reprogramming of the preimplantation embryo, in a poised but restrained state, regulating their availability for early embryonic development (PubMed:41845018, PubMed:41917274, PubMed:41986725). Cytoplasmic lattices also tightly control ubiquitination during the oocyte-to-embryo transition by trapping E3 ubiquitin-protein ligase UHRF1 in a compact autoinhibited conformation and maintaining SCF ubiquitin ligase complexes inactive (PubMed:38060382, PubMed:41845018, PubMed:41917274, PubMed:41951593, PubMed:41986725). Also plays a role in spermatogenesis by regulating differentiation of primordial germ cell-like cells, possibly by protecting HSPA2 from proteasome-mediated degradation (PubMed:32839316). {ECO:0000269|PubMed:32839316, ECO:0000269|PubMed:38060382, ECO:0000269|PubMed:41845018, ECO:0000269|PubMed:41917274, ECO:0000269|PubMed:41951593, ECO:0000269|PubMed:41986725}.
uniprot
proteins
mass_dalton
113386
uniprot
proteins
protein_family
NLRP family
uniprot
proteins
pubmed
15317747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15590904
uniprot
proteins
pubmed
32839316
uniprot
proteins
pubmed
38060382
uniprot
proteins
pubmed
41845018
uniprot
proteins
pubmed
41917274
uniprot
proteins
pubmed
41951593
uniprot
proteins
pubmed
41986725
uniprot
proteins
sequence_length
993
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15590904, ECO:0000269|PubMed:38060382}.
uniprot
proteins