Bsn
entrez
12217
canonical
uniprot
O88737
canonical
ensembl
ENSMUSG00000032589
resolver
ensp
ENSMUSP00000035208
resolver
genesymbol
Bsn
resolver
genesymbol_syn
Kiaa0434
resolver
uniprot
E9QMZ3
resolver
uniprot
Q3UXD6
resolver
uniprot
Q6ZQB5
resolver
uniprot_entry
BSN_MOUSE
resolver
uniprot_entry
Q3UXD6_MOUSE
resolver
uniprot_sec
E9QMZ3
resolver
uniprot_sec
Q6ZQB5
resolver
amino_acid_sequence
MGNEASLEGGAGEGPLPPGGSGLGPGPGAGKPPSALAGGGQLPVAGAARAAGPPTPGLGPVPGPGPGPGPGSVPRRLDPKEPLGSQRTTSPTPKQASATAPGRESPRETRAQGPSGQEAESPRRTLQVDSRTQRSGRSPSVSPDRGSTPTSPYSVPQIAPLPSSTLCPICKTSDLTSTPSQPNFNTCTQCHNKVCNQCGFNPNPHLTQVKEWLCLNCQMQRALGMDMTTAPRSKSQQQLHSPALSPAHSPAKQPLGKPEQERSPRGPGATQSGPRQAEAARATSVPGPTQATAPPEVGRVSPQPPLSTKPSTAEPRPPAGEAQGKSATTVPSGLGAGEQTQEGLTGKLFGLGASLLTQASTLMSVQPEADTQGQPSPSKGQPKIVFSDASKEAGPRPPGSGPGPGPTPGAKTEPGARMGPGSGPGALAKTGGTASPKHGRAEHQAASKAAAKPKTMPKERASACPLCQAELNMGSRGPANYNTCTACKLQVCNLCGFNPTPHLVEKTEWLCLNCQTKRLLEGSLGEPAPLPLPTPQQPPAGVPHRAAGAAPLKQKGPQGLGQPSGSLPAKASPQATKASPQATKASPQATKASPQTTKASPQAKPLRATEPSKTSSSAQEKKTVTSAKAEPVPKPPPETTVPPGTPKAKSGVKRTDPATPVVKPVPEAPKGGEAEEPVPKPYSQDLSRSPQSLSDTGYSSDGVSSSQSEITGVVQQEVEQLDSAGVTGPRPPSPSELHKVGSSLRPSLEAQAVAPSAEWSKPPRSSSSAVEDQKRRPHSLSITPEAFDSDEELGDILEEDDSLAWGRQREQQDTAESSDDFGSQLRHDYVEDSSEGGLSPLPPQPPARADMTDEEFMRRQILEMSAEEDNLEEDDTAVSGRGLAKHSAQKASARPRPESSQEPKRRLPHNATTGYEELLSEAGPAEPTDSSGALQGGLRRFKTIELNSTGSYGHELDLGQGPDPNLDREPELEMESLTGSPEDRSRGEHSSTLPASTPSYTSGTSPTSLSSLEEDSDSSPSRRQRLEEAKQQRKARHRSHGPLLPTIEDSSEEEELREEEELLREQEKMREVEQQRIRSTARKTRRDKEELRAQRRRERSKTPPSNLSPIEDASPTEELRQAAEMEELHRSSCSEYSPSPSLDSEAETLDGGPTRLYKSGSEYNLPAFMSLYSPTETPSGSSTTPSSGRPLKSAEEAYEDMMRKAEMLQRQQGQVAGARGPHGGPSQPTGPRSQGSFEYQDTQDHDYGGRASQPVAESTPAGLGAAVYEEILQTSQSIARMRQASSRDLGFTEDKKKEKQFLNAESAYMDPMKQNGGPLTPGTSPTQLAAPVSFSTSTSSDSSGGRVIPDVRVTQHFAKEPQDPLKLHSSPVSSTLTSKEVGMTFSQGPGSPATTASPTRGYMTPTSPAGSERSPSTSSTIHSYGQPPTTANYGSQTEELPHAPSGPPGSGRAPREKPLSGGDSEVGAPQPSRGYSYFTGSSPPLSPSTPSESPTFSPGKLGPRATAEFSTQTPSLTLSSDIPRSPGPPSPMVAQGTQTPHRPSTPRLVWQQSSQEAPIMVITLASDASSQTRMVHASASTSPLCSPTDSQPTSHSYSQTTPPSASQMPSEPAGPPGFPRAPSAGTDGPLALYGWGALPAENISLCRISSVPGTSRVEPGPRPPGTAVVDLRTAVKPTPIILTDQGMDLTSLAVEARKYGLALDPVSGRQSTAVQPLVINLNAQEQTHTFLATATTVSITMASSVLMAQQKQPVVYGDPFQSRLDFGQGSGSPVCLAQVKQVEQAVQTAPYRGGPRGRPREAKFARYNLPNQVTPLARRDILITQMGTAQGVGLKPGPVPEPGAEPHRATPAELRSHAPPGTRKPHTVVVQMGEGTAGTVTTLLPEEPAGALDLTGMRPESQLACCDMVYKFPFGSSCTGTFHPAPSAPDKSVTDTALPGQSSGPFYSPRDPEPPEPLTFRTQGVVGPGPHEEQRPYPQGLPGRLYSSMSDTNLAEAGLNYHAQRLGQLFQGPGRDSAVDLSSLKHSYSLGFADGRYLGQGLQYGSFTDLRHPTDLLSHPLPLRRYSSVSNIYSDHRYGPRGDAVGFQEASLAQYSATTAREISRMCAALNSMDQYGGRHGSGSGGPDLVQYQPQHGPGLSAPQGLAPLRSGLLGNPTYPEGQPSPGNLAQYGPAASQATAVRQLLPSTATVRAADGMIYSTINTPIAATLPITTQPASVLRPMVRGGMYRPYVSGGVTAVPLTSLTRVPMIAPRVPLGPAGLYRYPAPRFPIASSVPPAEGPVYLGKPAAAKASGAGGPPRPELPAGVAREEPFSTTAPAVIKEAPVAPAPGPAPAPPPGQKPAGEAVAGSGSGVLSRPASEKEEASQEDRQRKQQEQLLQLERERVELEKLRQLRLQEELERERVELQRHREEEQLLVQRELQELQTIKQHVLQQQQEERQAQFALQREQLAQQRLQLEQIQQLQQQLQLQLEEQKQRQKAPFPATCEAPSRGPPPAATELAQNGQYWPPLTHAAFIAVAGTEGPGQPREPVLHRGLPSSASDMSLQTEEQWEAGRSGIKKRHSMPRLRDACEPESGPDPSTVRRIADSSVQTDDEEGEGRYLVTRRRRTRRSADCSVQTDDEDNADWEQPVRRRRSRLSRHSDSGSDSKHDATASSSTTAAATARAMSSVGIQTISDCSVQTEPEQLPRVSPAIHITAATDPKVEIVRYISAPEKTGRGESLACQTEPDGQAQGVAGPQLIGPTAISPYLPGIQIVTPGALGRFEKKKPDPLEIGYQAHLPPESLSQLVSRQPPKSPQVLYSPVSPLSPHRLLDTSFASSERLNKAHVSPQKQFIADSTLRQQTLPRPMKTLQRSLSDPKPLSPTAEESAKERFSLYQHQGGLGSQVSALPPNGLVRKVKRTLPSPPPEEAHLPLAGQVPSQLYAASLLQRGLAGPTTVPATKASLLRELDRDLRLVEHESTKLRKKQAELDEEEKEIDAKLKYLELGITQRKESLAKDRGGRDYPPLRGLGEHRDYLSDSELNQLRLQGCTTPAGQYVDYPASAAVPATPSGPTAFQQPRFPPAAPQYTAGSSGPTQNGFPAHQAPTYTGPSTYPAPTYPPGTGYPAEPGLPSQPAFHPTGHYAAPTPMPTTQSAPFPVQADSRAAHQKPRQTSLADLEQKVPTNYEVIGSPAVTMSSAPPETGYSGPAVSGSYEQGKAPEHPRGSDRSSVSQSPAPTYPSDSHYTSLEQNVPRNYVMIDDISELTKDSTPTASESQRLEPLGPGGVSGRPGKDPGEPAVLEGPTLPCCYGRGEEESEEDSYDPRGKSGHHRSMESNGRPSTHYYGDSDYRHGARADKYGPGPMGPKHPSKSLAPAAISSKRSKHRKQGMEQKISKFSPIEEAKDVESDLASYPPPTVSSSLTSRGRKFQDEITYGLKKNVYEQQRYYGVSSRDAAEEDERMYGSSSRSRMASAYSGEKLSSHDYSSRGKGYERERDTAERLQKAGSKPSSLSMAHGRARPPMRSQASEEESPVSPLGRPRPAGGALPPGDTCPQFCSSHSMPDVQEHVKDGPRAHAYKREEGYMLDDSHCVVSDSEAYHLGQEETDWFDKPRDARSDRFRHHGGHTVSSSQKRGPARHSYHDYDEPPEEGLWPHDEGGPGRHTSAKEHRHHSDHGRHSGRHAGEEPGRRAAKPHARDMGRHEARPHPQASPAPAMQKKGQPGYPSSADYSQSSRAPSAYHHASESKKGSRQAHTGPSALQPKADTQAQPQMQGRQAAPGPQQSQPPSSRQTPSGTASRQPQTQQQQQQQQQQQGLGQQAPQQAPSQARLQPQSQPTTRGTAPAASQPAGKPQPGPTTAPGPQPAGPPRAEQASSSKPPAAKAPQQGRAPQAQTTPGPGPAGAKPGARPGGTPGAPASQPGAEGESVFSKILPGGAAEQAGKLTEAVSAFGKKFSSFW
uniprot
proteins
function
FUNCTION: Scaffold protein of the presynaptic cytomatrix at the active zone (CAZ) which is the place in the synapse where neurotransmitter is released (PubMed:12628168, PubMed:12628169, PubMed:19812333). After synthesis, participates in the formation of Golgi-derived membranous organelles termed Piccolo-Bassoon transport vesicles (PTVs) that are transported along axons to sites of nascent synaptic contacts (By similarity). At the presynaptic active zone, regulates the spatial organization of synaptic vesicle cluster, the protein complexes that execute membrane fusion and compensatory endocytosis (By similarity). Also functions in processes other than assembly such as the regulation of specific presynaptic protein ubiquitination by interacting with SIAH1 or the regulation of presynaptic autophagy by associating with ATG5 (By similarity) (PubMed:28231469). Also mediates synapse to nucleus communication leading to reconfiguration of gene expression by associating with the transcriptional corepressor CTBP1 and by subsequently reducing the size of its pool available for nuclear import (By similarity). Inhibits the activity of the proportion of DAO enzyme that localizes to the presynaptic active zone, which may modulate synaptic transmission (By similarity). {ECO:0000250|UniProtKB:O35078, ECO:0000250|UniProtKB:O88778, ECO:0000250|UniProtKB:Q9UPA5, ECO:0000269|PubMed:12628168, ECO:0000269|PubMed:12628169, ECO:0000269|PubMed:19812333, ECO:0000269|PubMed:28231469}.
uniprot
proteins
mass_dalton
418843
uniprot
proteins
post_translational_modification
PTM: Myristoylated. The N-terminal myristoylation is not sufficient for presynaptic localization (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
12628168
uniprot
proteins
pubmed
12628169
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
16452088
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
17869247
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19812333
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
28231469
uniprot
proteins
pubmed
9679147
uniprot
proteins
sequence_length
3942
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O88778}. Presynaptic active zone {ECO:0000269|PubMed:12628168, ECO:0000269|PubMed:12628169}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O88778}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:12628169}; Peripheral membrane protein {ECO:0000250|UniProtKB:O88778}. Note=In retina, is localized in the outer plexiform layer at ribbon synapses formed by rods and cones but was absent from basal synaptic contacts formed by cones. In the retinal inner plexiform layer localized to conventional inhibitory GABAergic synapses, made by amacrine cells, but absent from the bipolar cell ribbon synapses (By similarity). {ECO:0000250|UniProtKB:O88778}.
uniprot
proteins