CD248
entrez
57124
canonical
uniprot
Q9HCU0
canonical
ensembl
ENSG00000174807
resolver
ensp
ENSP00000308117
resolver
genesymbol
CD248
resolver
genesymbol_syn
CD164L1
resolver
genesymbol_syn
TEM1
resolver
hgnc
HGNC:18219
resolver
uniprot
Q2M2V5
resolver
uniprot
Q3SX55
resolver
uniprot
Q96KB6
resolver
uniprot_entry
CD248_HUMAN
resolver
uniprot_sec
Q2M2V5
resolver
uniprot_sec
Q3SX55
resolver
uniprot_sec
Q96KB6
resolver
amino_acid_sequence
MLLRLLLAWAAAGPTLGQDPWAAEPRAACGPSSCYALFPRRRTFLEAWRACRELGGDLATPRTPEEAQRVDSLVGAGPASRLLWIGLQRQARQCQLQRPLRGFTWTTGDQDTAFTNWAQPASGGPCPAQRCVALEASGEHRWLEGSCTLAVDGYLCQFGFEGACPALQDEAGQAGPAVYTTPFHLVSTEFEWLPFGSVAAVQCQAGRGASLLCVKQPEGGVGWSRAGPLCLGTGCSPDNGGCEHECVEEVDGHVSCRCTEGFRLAADGRSCEDPCAQAPCEQQCEPGGPQGYSCHCRLGFRPAEDDPHRCVDTDECQIAGVCQQMCVNYVGGFECYCSEGHELEADGISCSPAGAMGAQASQDLGDELLDDGEDEEDEDEAWKAFNGGWTEMPGILWMEPTQPPDFALAYRPSFPEDREPQIPYPEPTWPPPLSAPRVPYHSSVLSVTRPVVVSATHPTLPSAHQPPVIPATHPALSRDHQIPVIAANYPDLPSAYQPGILSVSHSAQPPAHQPPMISTKYPELFPAHQSPMFPDTRVAGTQTTTHLPGIPPNHAPLVTTLGAQLPPQAPDALVLRTQATQLPIIPTAQPSLTTTSRSPVSPAHQISVPAATQPAALPTLLPSQSPTNQTSPISPTHPHSKAPQIPREDGPSPKLALWLPSPAPTAAPTALGEAGLAEHSQRDDRWLLVALLVPTCVFLVVLLALGIVYCTRCGPHAPNKRITDCYRWVIHAGSKSPTEPMPPRGSLTGVQTCRTSV
uniprot
proteins
function
FUNCTION: Cell surface glycoprotein involved in various biological processes including angiogenesis, immune response modulation, and tissue remodeling and repair. Participates in pericyte proliferation through positive modulation of the PDGF receptor signaling pathway (PubMed:20484976). Acts as a scaffold for factor X, triggering allosteric changes and the spatial re-alignment of factor X with the TF-factor VIIa complex, thereby enhancing coagulation activation. Modulates the insulin signaling pathway by interacting with insulin receptor/INSR and by diminishing its capacity to be autophosphorylated in response to insulin. Also regulates LPS-induced inflammatory response in macrophages by favoring the production of proinflammatory cytokines. In human, negatively regulates T-cell proliferation compared with stromal cells where it increases proliferation (PubMed:21466550). {ECO:0000250|UniProtKB:Q91V98, ECO:0000269|PubMed:15862292, ECO:0000269|PubMed:20484976, ECO:0000269|PubMed:21466550, ECO:0000269|PubMed:28671670}.
uniprot
proteins
mass_dalton
80859
uniprot
proteins
post_translational_modification
PTM: O-glycosylated with sialylated oligosaccharides. {ECO:0000269|PubMed:1438285}.; PTM: May be N-glycosylated. {ECO:0000269|PubMed:1438285}.
uniprot
proteins
pubmed
10947988
uniprot
proteins
pubmed
11084048
uniprot
proteins
pubmed
1438285
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15862292
uniprot
proteins
pubmed
16076089
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
20484976
uniprot
proteins
pubmed
21466550
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28671670
uniprot
proteins
sequence_length
757
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 688..708; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins