KCNK13
entrez
56659
canonical
uniprot
Q9HB14
canonical
ensembl
ENSG00000152315
resolver
ensp
ENSP00000282146
resolver
enst
ENST00000282146
resolver
genesymbol
KCNK13
resolver
hgnc
HGNC:6275
resolver
uniprot
B5TJL8
resolver
uniprot
Q96E79
resolver
uniprot_entry
KCNKD_HUMAN
resolver
uniprot_sec
B5TJL8
resolver
uniprot_sec
Q96E79
resolver
activity_regulation
ACTIVITY REGULATION: Activated by anionic lipids such as phosphatidylinositol 4,5-bisphosphate (PI[4,5]P2 or PIP2) and oleoyl-CoA (PubMed:40011745). Activated by arachidonic acid (PubMed:30472253, PubMed:40307591). Inhibited by channel blocker tetrapentylammonium (PubMed:40307591). Inhibited by Ba(2+) ions, volatile anesthetics such as halothane and isoflurane, and antiarrhythmic drugs mexiletine and lidocaine (PubMed:30472253, PubMed:40178898). Insensitive to extracellular pH change (PubMed:24163367). {ECO:0000269|PubMed:24163367, ECO:0000269|PubMed:30472253, ECO:0000269|PubMed:40011745, ECO:0000269|PubMed:40178898, ECO:0000269|PubMed:40307591}.
uniprot
proteins
amino_acid_sequence
MAGRGFSWGPGHLNEDNARFLLLAALIVLYLLGGAAVFSALELAHERQAKQRWEERLANFSRGHNLSRDELRGFLRHYEEATRAGIRVDNVRPRWDFTGAFYFVGTVVSTIGFGMTTPATVGGKIFLIFYGLVGCSSTILFFNLFLERLITIIAYIMKSCHQRQLRRRGALPQESLKDAGQCEVDSLAGWKPSVYYVMLILCTASILISCCASAMYTPIEGWSYFDSLYFCFVAFSTIGFGDLVSSQNAHYESQGLYRFANFVFILMGVCCIYSLFNVISILIKQSLNWILRKMDSGCCPQCQRGLLRSRRNVVMPGSVRNRCNISIETDGVAESDTDGRRLSGEMISMKDLLAANKASLAILQKQLSEMANGCPHQTSTLARDNEFSGGVGAFAIMNNRLAETSGDR
uniprot
proteins
function
FUNCTION: K(+) channel that conducts outward rectifying tonic currents potentiated by purinergic signals (PubMed:24163367, PubMed:25148687, PubMed:30472253, PubMed:38409076). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:25148687, PubMed:40011745, PubMed:40011746, PubMed:40307591, PubMed:40178898). Contributes most of K(+) currents at the plasma membrane of resting microglia (PubMed:38409076). Maintains a depolarized membrane potential required for proper ramified microglia morphology and phagocytosis, selectively mediating microglial pruning of presynaptic compartments at hippocampal excitatory synapses (PubMed:38409076). Upon local release of ATP caused by neuronal injury or infection, it is potentiated by P2RY12 and P2RX7 receptor signaling and contributes to ATP-triggered K(+) efflux underlying microglial NLRP3 inflammasome assembly and IL1B release (PubMed:38409076). {ECO:0000269|PubMed:24163367, ECO:0000269|PubMed:25148687, ECO:0000269|PubMed:30472253, ECO:0000269|PubMed:38409076, ECO:0000269|PubMed:40011745, ECO:0000269|PubMed:40011746, ECO:0000269|PubMed:40178898, ECO:0000269|PubMed:40307591}.
uniprot
proteins
mass_dalton
45391
uniprot
proteins
mutagenesis
MUTAGEN 87; /note="R->D: Decreases channel basal activity."; /evidence="ECO:0000269|PubMed:40011745"; MUTAGEN 112; /note="G->E: Acts as a dominant negative when it assembles with wild-type KCNK13 or KCNK12 subunits, abolishing K(+) flux."; /evidence="ECO:0000269|PubMed:25148687"; MUTAGEN 136; /note="S->P: Increases channel basal activity. Increases the current amplitude. Confers nonlinear I-V relationship, with currents that saturate upon strong membrane depolarization; when associated with D-139. Does not affect channel ion selectivity, pH sensitivity nor inhibition by halothane."; /evidence="ECO:0000269|PubMed:24163367, ECO:0000269|PubMed:40307591"; MUTAGEN 139; /note="I->A: Increases channel basal activity."; /evidence="ECO:0000269|PubMed:40011745, ECO:0000269|PubMed:40011746, ECO:0000269|PubMed:40307591"; MUTAGEN 139; /note="I->D: Increases channel basal activity. Increases the current amplitude. Confers nonlinear I-V relationship, with currents that saturate upon strong membrane depolarization; when associated with P-136."; /evidence="ECO:0000269|PubMed:24163367"; MUTAGEN 261; /note="N->A: Decreases channel basal activity."; /evidence="ECO:0000269|PubMed:40011746, ECO:0000269|PubMed:40307591"; MUTAGEN 273; /note="Y->A: Increases channel basal activity."; /evidence="ECO:0000269|PubMed:40011745, ECO:0000269|PubMed:40011746, ECO:0000269|PubMed:40307591
uniprot
proteins
protein_family
Two pore domain potassium channel (TC 1.A.1.8) family
uniprot
proteins
pubmed
11060316
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18516069
uniprot
proteins
pubmed
24163367
uniprot
proteins
pubmed
25148687
uniprot
proteins
pubmed
30472253
uniprot
proteins
pubmed
38409076
uniprot
proteins
pubmed
40011745
uniprot
proteins
pubmed
40011746
uniprot
proteins
pubmed
40178898
uniprot
proteins
pubmed
40307591
uniprot
proteins
sequence_length
408
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24163367, ECO:0000269|PubMed:25148687}; Multi-pass membrane protein {ECO:0000269|PubMed:40011745, ECO:0000269|PubMed:40011746, ECO:0000269|PubMed:40178898, ECO:0000269|PubMed:40307591}.
uniprot
proteins
transmembrane_region
TRANSMEM 20..41; /note="Helical; Name=M1"; /evidence="ECO:0000269|PubMed:40011745, ECO:0000269|PubMed:40011746, ECO:0000269|PubMed:40178898, ECO:0000269|PubMed:40307591, ECO:0007744|PDB:9BSN, ECO:0007744|PDB:9BWS, ECO:0007744|PDB:9BYI, ECO:0007744|PDB:9C07, ECO:0007744|PDB:9C09, ECO:0007744|PDB:9DWN, ECO:0007744|PDB:9FT7, ECO:0007744|PDB:9JGZ, ECO:0007744|PDB:9JH1"; TRANSMEM 125..145; /note="Helical; Name=M2"; /evidence="ECO:0000269|PubMed:40011745, ECO:0000269|PubMed:40011746, ECO:0000269|PubMed:40178898, ECO:0000269|PubMed:40307591, ECO:0007744|PDB:9BSN, ECO:0007744|PDB:9BWS, ECO:0007744|PDB:9BYI, ECO:0007744|PDB:9C07, ECO:0007744|PDB:9C09, ECO:0007744|PDB:9DWN, ECO:0007744|PDB:9FT7, ECO:0007744|PDB:9JGZ, ECO:0007744|PDB:9JH1"; TRANSMEM 197..217; /note="Helical; Name=M3"; /evidence="ECO:0000269|PubMed:40011745, ECO:0000269|PubMed:40011746, ECO:0000269|PubMed:40178898, ECO:0000269|PubMed:40307591, ECO:0007744|PDB:9BSN, ECO:0007744|PDB:9BWS, ECO:0007744|PDB:9BYI, ECO:0007744|PDB:9C07, ECO:0007744|PDB:9C09, ECO:0007744|PDB:9DWN, ECO:0007744|PDB:9FT7, ECO:0007744|PDB:9JGZ, ECO:0007744|PDB:9JH1"; TRANSMEM 259..279; /note="Helical; Name=M4"; /evidence="ECO:0000269|PubMed:40011745, ECO:0000269|PubMed:40011746, ECO:0000269|PubMed:40178898, ECO:0000269|PubMed:40307591, ECO:0007744|PDB:9BSN, ECO:0007744|PDB:9BWS, ECO:0007744|PDB:9BYI, ECO:0007744|PDB:9C07, ECO:0007744|PDB:9C09, ECO:0007744|PDB:9DWN, ECO:0007744|PDB:9FT7, ECO:0007744|PDB:9JGZ, ECO:0007744|PDB:9JH1
uniprot
proteins