Myt1l
entrez
17933
canonical
uniprot
P97500
canonical
ensembl
ENSMUSG00000061911
resolver
ensp
ENSMUSP00000021009
resolver
ensp
ENSMUSP00000058264
resolver
ensp
ENSMUSP00000151588
resolver
ensp
ENSMUSP00000319743
resolver
ensp
ENSMUSP00000319746
resolver
ensp
ENSMUSP00000319749
resolver
ensp
ENSMUSP00000319751
resolver
ensp
ENSMUSP00000319756
resolver
ensp
ENSMUSP00000319757
resolver
ensp
ENSMUSP00000319760
resolver
ensp
ENSMUSP00000319762
resolver
ensp
ENSMUSP00000319764
resolver
ensp
ENSMUSP00000319771
resolver
ensp
ENSMUSP00000319772
resolver
ensp
ENSMUSP00000319774
resolver
ensp
ENSMUSP00000319775
resolver
ensp
ENSMUSP00000319777
resolver
ensp
ENSMUSP00000319783
resolver
ensp
ENSMUSP00000319784
resolver
ensp
ENSMUSP00000319788
resolver
ensp
ENSMUSP00000319797
resolver
ensp
ENSMUSP00000319804
resolver
ensp
ENSMUSP00000319805
resolver
ensp
ENSMUSP00000319808
resolver
ensp
ENSMUSP00000319809
resolver
genesymbol
Myt1l
resolver
genesymbol_syn
Kiaa1106
resolver
genesymbol_syn
Nzf1
resolver
genesymbol_syn
Png1
resolver
uniprot
A2RRK5
resolver
uniprot
D3Z1P7
resolver
uniprot
O08996
resolver
uniprot
Q0VGN2
resolver
uniprot
Q33DP0
resolver
uniprot
Q8C643
resolver
uniprot
Q8C7L4
resolver
uniprot
Q8CHB4
resolver
uniprot_entry
MYT1L_MOUSE
resolver
uniprot_entry
Q0VGN2_MOUSE
resolver
uniprot_sec
A2RRK5
resolver
uniprot_sec
D3Z1P7
resolver
uniprot_sec
O08996
resolver
uniprot_sec
Q33DP0
resolver
uniprot_sec
Q8C643
resolver
uniprot_sec
Q8C7L4
resolver
uniprot_sec
Q8CHB4
resolver
amino_acid_sequence
MDVDSEEKRHRTRSKGVRVPVEPAIQELFSCPTPGCDGSGHVSGKYARHRSVYGCPLAKKRKTQDKQPQEPAPKRKPFAVKADSSSVDECYESDGTEDMDDKEEDDDEEFSEDNDEQGDDDDEDEVDREDEEEIEEEDDEEDDDDEDGDDVEEEEEDDDEEEEEEEEEEENEDHQMSCTRIMQDTDKDDNNNDEYDNYDELVAKSLLNLGKIAEDAAYRARTESEMNSNTSNSLEDDSDKNENLGRKSELSLDLDSDVVRETVDSLKLLAQGHGVVLSENISDRSYAEGMSQQDSRNMNYVMLGKPMNNGLMEKMVEESDEEVCLSSLECLRNQCFDLARKLSETNPQDRSQPPNMSVRQHVRQEDDFPGRTPDRSYSDMMNLMRLEEQLSPRSRTFSSCAKEDGCHERDDDTTSVNSDRSEEVFDMTKGNLTLLEKAIALETERAKAMREKMAMDAGRRDNLRSYEDQSPRQLAGEDRKSKSSDSHVKKPYYGKDPSRTEKRESKCPTPGCDGTGHVTGLYPHHRSLSGCPHKDRVPPEILAMHENVLKCPTPGCTGRGHVNSNRNSHRSLSGCPIAAAEKLAKAQEKHQSCDVSKSNQASDRVLRPMCFVKQLEIPQYGYRNNVPTTTPRSNLAKELEKYSKTSFEYNSYDNHTYGKRAIAPKVQTRDISPKGYDDAKRYCKNASPSSSTTSSYAPSSSSNLSCGGGSSASSTCSKSSFDYTHDMEAAHMAATAILNLSTRCREMPQNLSTKPQDLCTARNPDMEVDENGTLDLSMNKQRPRDSCCPVLTPLEPMSPQQQAVMSSRCFQLSEGDCWDLPVDYTKMKPRRVDEDEPKEITPEDLDPFQEALEERRYPGEVTIPSPKPKYPQCKESKKDLITLSGCPLADKSIRSMLATSSQELKCPTPGCDGSGHITGNYASHRSLSGCPRAKKSGIRIAQSKEDKEDQEPIRCPVPGCDGQGHITGKYASHRSASGCPLAAKRQKDGYLNGSQFSWKSVKTEGMSCPTPGCDGSGHVSGSFLTHRSLSGCPRATSAMKKAKLSGEQMLTIKQRASNGIENDEEIKQLDEEIKELNESNSQMEADMIKLRTQITTMESNLKTIEEENKVIEQQNESLLHELANLSQSLIHSLANIQLPHMDPINEQNFDAYVTTLTEMYTNQDRYQSPENKALLENIKQAVRGIQV
uniprot
proteins
function
FUNCTION: Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation (PubMed:28379941). In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs (PubMed:28379941). Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1 (PubMed:28379941). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (PubMed:20107439, PubMed:24243019, PubMed:27281220). Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B (PubMed:28379941). The 5'-AAGTT-3' core motif is absent from the promoter of neural genes (PubMed:28379941). {ECO:0000269|PubMed:20107439, ECO:0000269|PubMed:24243019, ECO:0000269|PubMed:27281220, ECO:0000269|PubMed:28379941, ECO:0000269|PubMed:9130664, ECO:0000269|PubMed:9373037}.
uniprot
proteins
mass_dalton
132945
uniprot
proteins
protein_family
MYT1 family
uniprot
proteins
pubmed
12465718
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20107439
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21540077
uniprot
proteins
pubmed
24243019
uniprot
proteins
pubmed
27281220
uniprot
proteins
pubmed
28379941
uniprot
proteins
pubmed
9130664
uniprot
proteins
pubmed
9373037
uniprot
proteins
sequence_length
1187
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24243019, ECO:0000269|PubMed:28379941, ECO:0000269|PubMed:9373037}. Chromosome {ECO:0000269|PubMed:28379941}. Note=Preferentially binds to DNA binding sites that are in an open chromatin configuration (PubMed:28379941). {ECO:0000269|PubMed:28379941}.
uniprot
proteins