PDE11A
entrez
50940
canonical
uniprot
Q9HCR9
canonical
ensembl
ENSG00000128655
resolver
ensp
ENSP00000286063
resolver
ensp
ENSP00000351232
resolver
ensp
ENSP00000374333
resolver
ensp
ENSP00000386539
resolver
genesymbol
PDE11A
resolver
hgnc
HGNC:8773
resolver
uniprot
Q14CD1
resolver
uniprot
Q53T16
resolver
uniprot
Q96S76
resolver
uniprot
Q9GZY7
resolver
uniprot
Q9HB46
resolver
uniprot
Q9NY45
resolver
uniprot_entry
PDE11_HUMAN
resolver
uniprot_sec
Q14CD1
resolver
uniprot_sec
Q53T16
resolver
uniprot_sec
Q96S76
resolver
uniprot_sec
Q9GZY7
resolver
uniprot_sec
Q9HB46
resolver
uniprot_sec
Q9NY45
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by 3-isobutyl-1-methylxanthine (IBMX), zaprinast and dipyridamole. cGMP acts as an allosteric activator. Weakly inhibited by Sildenafil (Viagra) and Tadalafil (Cialis); however, the fact that the protein is probably absent from testis, suggests that it is not biologically relevant and is not related with erectile dysfunction. {ECO:0000269|PubMed:10725373, ECO:0000269|PubMed:11050148, ECO:0000269|PubMed:16079899, ECO:0000269|PubMed:16330539}.
uniprot
proteins
amino_acid_sequence
MAASRLDFGEVETFLDRHPELFEDYLMRKGKQEMVEKWLQRHSQGQGALGPRPSLAGTSSLAHSTCRGGSSVGGGTGPNGSAHSQPLPGGGDCGGVPLSPSWAGGSRGDGNLQRRASQKELRKSFARSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRKASSLPPTTAHILSALLESRVNLPRYPPTAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSLFLVEGAAAGKKTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIPDAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQMYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKCERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVASTGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFDDADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANIPLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRMVLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSGSALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLYFERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFEQGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVATNRSKWEELHQKRLLASTASSSPASVMVAKEDRN
uniprot
proteins
disease_involvement
DISEASE: Primary pigmented nodular adrenocortical disease 2 (PPNAD2) [MIM:610475]: A rare bilateral adrenal defect causing ACTH-independent Cushing syndrome. Macroscopic appearance of the adrenals is characteristic with small pigmented micronodules observed in the cortex. Adrenal glands show overall normal size and weight, and multiple small yellow-to-dark brown nodules surrounded by a cortex with a uniform appearance. Microscopically, there are moderate diffuse cortical hyperplasia with mostly nonpigmented nodules, multiple capsular deficits and massive circumscribed and infiltrating extra-adrenal cortical excrescences with micronodules. Clinical manifestations of Cushing syndrome include facial and truncal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes. {ECO:0000269|PubMed:16767104}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.1.4.35
uniprot
proteins
ec_number
3.1.4.53
uniprot
proteins
function
FUNCTION: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP (PubMed:10725373, PubMed:10906126, PubMed:11050148, PubMed:16330539). Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (PubMed:10725373, PubMed:10906126, PubMed:11050148). {ECO:0000269|PubMed:10725373, ECO:0000269|PubMed:10906126, ECO:0000269|PubMed:11050148, ECO:0000269|PubMed:16330539}.
uniprot
proteins
mass_dalton
104752
uniprot
proteins
mutagenesis
MUTAGEN 355; /note="D->A: Induces a decrease in enzyme activity due to the inability of cGMP to bind and stimulate enzyme activity."; /evidence="ECO:0000269|PubMed:16330539
uniprot
proteins
protein_family
Cyclic nucleotide phosphodiesterase family
uniprot
proteins
pubmed
10725373
uniprot
proteins
pubmed
10906126
uniprot
proteins
pubmed
11050148
uniprot
proteins
pubmed
11121118
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15800651
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16079899
uniprot
proteins
pubmed
16330539
uniprot
proteins
pubmed
16767104
uniprot
proteins
pubmed
19690332
uniprot
proteins
sequence_length
933
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10906126}.
uniprot
proteins