ANGEL2
entrez
90806
canonical
uniprot
Q5VTE6
canonical
ensembl
ENSG00000174606
resolver
ensp
ENSP00000353696
resolver
ensp
ENSP00000355929
resolver
ensp
ENSP00000438141
resolver
ensp
ENSP00000656887
resolver
genesymbol
ANGEL2
resolver
genesymbol_syn
KIAA0759L
resolver
hgnc
HGNC:30534
resolver
uniprot
B7Z297
resolver
uniprot
B7Z2U4
resolver
uniprot
B7Z5N3
resolver
uniprot
D3DTA3
resolver
uniprot
E7ER49
resolver
uniprot
Q86X13
resolver
uniprot
Q8NHH3
resolver
uniprot
Q96AL9
resolver
uniprot_entry
ANGE2_HUMAN
resolver
uniprot_entry
B7Z297_HUMAN
resolver
uniprot_entry
B7Z5N3_HUMAN
resolver
uniprot_entry
Q96AL9_HUMAN
resolver
uniprot_sec
B7Z2U4
resolver
uniprot_sec
D3DTA3
resolver
uniprot_sec
E7ER49
resolver
uniprot_sec
Q86X13
resolver
uniprot_sec
Q8NHH3
resolver
amino_acid_sequence
MEAWRCVRKGYGHCVVGRGRYPMFPHHSRSLGRDWTTPWENLQRCCWNRHISSCMRWPGHYSRAPYPYFSSRHFSLNWRPPCLFESRTQFQYCNWRPDNLSQTSLIHLSSYVMNAEGDEPSSKRRKHQGVIKRNWEYICSHDKEKTKILGDKNVDPKCEDSENKFDFSVMSYNILSQDLLEDNSHLYRHCRRPVLHWSFRFPNILKEIKHFDADVLCLQEVQEDHYGAEIRPSLESLGYHCEYKMRTGRKPDGCAICFKHSKFSLLSVNPVEFFRPDISLLDRDNVGLVLLLQPKIPYAACPAICVANTHLLYNPRRGDIKLTQLAMLLAEISSVAHQKDGSFCPIVMCGDFNSVPGSPLYSFIKEGKLNYEGLPIGKVSGQEQSSRGQRILSIPIWPPNLGISQNCVYEVQQVPKVEKTDSDLTQTQLKQTEVLVTAEKLSSNLQHHFSLSSVYSHYFPDTGIPEVTTCHSRSAITVDYIFYSAEKEDVAGHPGAEVALVGGLKLLARLSLLTEQDLWTVNGLPNENNSSDHLPLLAKFRLEL
uniprot
proteins
ec_number
3.-.-.-
uniprot
proteins
function
FUNCTION: RNA 2',3'-cyclic phosphatase that catalyzes the hydrolysis of RNA molecules with a 2',3'-cyclic phosphate at the 3' end to produce RNA with a linear 3'-phosphate group (PubMed:32732418, PubMed:36180430). Essential for the maturation and processing of mitochondrial RNAs, particularly those generated via non-canonical pathways (By similarity). Antagonizes pre-tRNA processing and XBP1 mRNA splicing during the unfolded protein response by limiting the availability of 2',3'-cyclic phosphate substrates for the tRNA ligase complex (PubMed:32732418). Promotes tRNA recycling by eliminating 2',3'-cyclic phosphate groups from cleaved tRNAs, thereby enabling the tRNA nucleotidyltransferase TRNT1 to reattach the CCA tail essential for aminoacylation and subsequent translation (PubMed:32732418). {ECO:0000250|UniProtKB:Q8K1C0, ECO:0000269|PubMed:32732418, ECO:0000269|PubMed:36180430}.
uniprot
proteins
mass_dalton
62339
uniprot
proteins
mutagenesis
MUTAGEN 173; /note="N->A: Reduced catalytic activity."; /evidence="ECO:0000269|PubMed:32732418"; MUTAGEN 220; /note="E->A: Loss of catalytic activity."; /evidence="ECO:0000269|PubMed:32732418"; MUTAGEN 310; /note="H->A: No effect on catalytic activity."; /evidence="ECO:0000269|PubMed:32732418"; MUTAGEN 351; /note="D->A: Loss of catalytic activity."; /evidence="ECO:0000269|PubMed:32732418"; MUTAGEN 353; /note="N->A: Reduced catalytic activity."; /evidence="ECO:0000269|PubMed:32732418"; MUTAGEN 532; /note="D->A: Loss of catalytic activity."; /evidence="ECO:0000269|PubMed:32732418"; MUTAGEN 533; /note="H->A: Reduced catalytic activity."; /evidence="ECO:0000269|PubMed:32732418
uniprot
proteins
protein_family
CCR4/nocturin family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
32732418
uniprot
proteins
pubmed
36180430
uniprot
proteins
sequence_length
544
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:36180430}.
uniprot
proteins