MXD1
entrez
4084
canonical
uniprot
Q05195
canonical
ensembl
ENSG00000059728
resolver
ensp
ENSP00000264444
resolver
ensp
ENSP00000443935
resolver
ensp
ENSP00000546242
resolver
genesymbol
MXD1
resolver
genesymbol_syn
MAD
resolver
hgnc
HGNC:6761
resolver
uniprot
B2R6V8
resolver
uniprot
B7ZLI6
resolver
uniprot
B7ZLI7
resolver
uniprot
D6W5G2
resolver
uniprot
Q6FI41
resolver
uniprot_entry
B7ZLI7_HUMAN
resolver
uniprot_entry
MAD1_HUMAN
resolver
uniprot_sec
B2R6V8
resolver
uniprot_sec
B7ZLI6
resolver
uniprot_sec
D6W5G2
resolver
uniprot_sec
Q6FI41
resolver
amino_acid_sequence
MAAAVRMNIQMLLEAADYLERREREAEHGYASMLPYNNKDRDALKRRNKSKKNNSSSRSTHNEMEKNRRAHLRLCLEKLKGLVPLGPESSRHTTLSLLTKAKLHIKKLEDCDRKAVHQIDQLQREQRHLKRQLEKLGIERIRMDSIGSTVSSERSDSDREEIDVDVESTDYLTGDLDWSSSSVSDSDERGSMQSLGSDEGYSSTSIKRIKLQDSHKACLGL
uniprot
proteins
function
FUNCTION: Component of a transcriptional repressor complex together with MAX (PubMed:8425218). In complex with MAX binds to the core DNA sequence 5'-CAC[GA]TG-3' (PubMed:8425218). Antagonizes MYC transcriptional activity by competing with MYC for MAX binding (PubMed:8425218). Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding (PubMed:12837246). {ECO:0000269|PubMed:12837246, ECO:0000269|PubMed:8425218}.
uniprot
proteins
mass_dalton
25254
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by BIRC2/c-IAP1, leading to its subsequent degradation by the proteasome. {ECO:0000269|PubMed:18082613}.
uniprot
proteins
pubmed
12837246
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18082613
uniprot
proteins
pubmed
8425218
uniprot
proteins
sequence_length
221
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:8425218}.
uniprot
proteins