Sema4a
entrez
20351
canonical
uniprot
Q62178
canonical
ensembl
ENSMUSG00000028064
resolver
ensp
ENSMUSP00000029700
resolver
ensp
ENSMUSP00000125909
resolver
ensp
ENSMUSP00000128510
resolver
ensp
ENSMUSP00000128887
resolver
ensp
ENSMUSP00000282926
resolver
ensp
ENSMUSP00000282943
resolver
ensp
ENSMUSP00000282949
resolver
ensp
ENSMUSP00000282950
resolver
enst
ENSMUST00000029700
resolver
enst
ENSMUST00000165898
resolver
enst
ENSMUST00000166237
resolver
enst
ENSMUST00000169222
resolver
genesymbol
Sema4a
resolver
genesymbol_syn
SemB
resolver
genesymbol_syn
Semab
resolver
uniprot
D3Z5L2
resolver
uniprot_entry
SEM4A_MOUSE
resolver
uniprot_sec
D3Z5L2
resolver
amino_acid_sequence
MALPSLGQDSWSLLRVFFFQLFLLPSLPPASGTGGQGPMPRVKYHAGDGHRALSFFQQKGLRDFDTLLLSDDGNTLYVGAREAVLALNIQNPGIPRLKNMIPWPASERKKTECAFKKKSNETQCFNFIRVLVSYNATHLYACGTFAFSPACTFIELQDSLLLPILIDKVMDGKGQSPFDPVHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVLKTDIFLRWLHADASFVAAIPSTQVVYFFFEETASEFDFFEELYISRVAQVCKNDVGGEKLLQKKWTTFLKAQLLCAQPGQLPFNIIRHAVLLPADSPSVSRIYAVFTSQWQVGGTRSSAVCAFSLTDIERVFKGKYKELNKETSRWTTYRGSEVSPRPGSCSMGPSSDKALTFMKDHFLMDEHVVGTPLLVKSGVEYTRLAVESARGLDGSSHVVMYLGTSTGSLHKAVVPQDSSAYLVEEIQLSPDSEPVRNLQLAPAQGAVFAGFSGGIWRVPRANCSVYESCVDCVLARDPHCAWDPESRLCSLLSGSTKPWKQDMERGNPEWVCTRGPMARSPRRQSPPQLIKEVLTVPNSILELPCPHLSALASYHWSHGRAKISEASATVYNGSLLLLPQDGVGGLYQCVATENGYSYPVVSYWVDSQDQPLALDPELAGVPRERVQVPLTRVGGGASMAAQRSYWPHFLIVTVLLAIVLLGVLTLLLASPLGALRARGKVQGCGMLPPREKAPLSRDQHLQPSKDHRTSASDVDADNNHLGAEVA
uniprot
proteins
function
FUNCTION: Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling (PubMed:17318185, PubMed:20043131). Regulates glutamatergic and GABAergic synapse development (PubMed:29981480). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner (PubMed:29981480). Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity (PubMed:15780988). Promotes phosphorylation of TIMD2 (PubMed:12374982). Inhibits angiogenesis (PubMed:17318185). Promotes axon growth cone collapse (PubMed:20043131). Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons (PubMed:20043131). {ECO:0000269|PubMed:12374982, ECO:0000269|PubMed:15780988, ECO:0000269|PubMed:17318185, ECO:0000269|PubMed:20043131, ECO:0000269|PubMed:29981480}.
uniprot
proteins
mass_dalton
83421
uniprot
proteins
protein_family
Semaphorin family
uniprot
proteins
pubmed
12374982
uniprot
proteins
pubmed
15277503
uniprot
proteins
pubmed
15780988
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17318185
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20043131
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29981480
uniprot
proteins
pubmed
7748561
uniprot
proteins
sequence_length
760
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12374982, ECO:0000269|PubMed:15780988, ECO:0000269|PubMed:17318185, ECO:0000269|PubMed:20043131}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 683..703; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins