Folh1
entrez
53320
canonical
uniprot
O35409
canonical
ensembl
ENSMUSG00000001773
resolver
ensp
ENSMUSP00000001824
resolver
ensp
ENSMUSP00000102892
resolver
ensp
ENSMUSP00000192735
resolver
ensp
ENSMUSP00000192736
resolver
enst
ENSMUST00000001824
resolver
enst
ENSMUST00000107271
resolver
genesymbol
Folh1
resolver
genesymbol_syn
Mopsm
resolver
genesymbol_syn
Naalad1
resolver
uniprot
F8WIX2
resolver
uniprot
Q0VDM5
resolver
uniprot
Q0VDM6
resolver
uniprot
Q9DCC2
resolver
uniprot_entry
F8WIX2_MOUSE
resolver
uniprot_entry
FOLH1_MOUSE
resolver
uniprot_entry
Q0VDM6_MOUSE
resolver
uniprot_sec
Q0VDM5
resolver
uniprot_sec
Q9DCC2
resolver
activity_regulation
ACTIVITY REGULATION: The NAALADase and folate hydrolase activities are inhibited by quisqualic acid.
uniprot
proteins
amino_acid_sequence
MWNALQDRDSAEVLGHRQRWLRVGTLVLALTGTFLIGFLFGWFIKPSNEATGNVSHSGMKKEFLHELKAENIKKFLYNFTRTPHLAGTQNNFELAKQIHDQWKEFGLDLVELSHYDVLLSYPNKTHPNYISIINEDGNEIFKTSLSEQPPPGYENISDVVPPYSAFSPQGTPEGDLVYVNYARTEDFFKLEREMKISCSGKIVIARYGKVFRGNMVKNAQLAGAKGMILYSDPADYFVPAVKSYPDGWNLPGGGVQRGNVLNLNGAGDPLTPGYPANEHAYRHELTNAVGLPSIPVHPIGYDDAQKLLEHMGGPAPPDSSWKGGLKVPYNVGPGFAGNFSTQKVKMHIHSYTKVTRIYNVIGTLKGALEPDRYVILGGHRDAWVFGGIDPQSGAAVVHEIVRSFGTLKKKGRRPRRTILFASWDAEEFGLLGSTEWAEEHSRLLQERGVAYINADSSIEGNYTLRVDCTPLMYSLVYNLTKELQSPDEGFEGKSLYDSWKEKSPSPEFIGMPRISKLGSGNDFEVFFQRLGIASGRARYTKNWKTNKVSSYPLYHSVYETYELVVKFYDPTFKYHLTVAQVRGAMVFELANSIVLPFDCQSYAVALKKYADTIYNISMKHPQEMKAYMISFDSLFSAVNNFTDVASKFNQRLQELDKSNPILLRIMNDQLMYLERAFIDPLGLPGRPFYRHIIYAPSSHNKYAGESFPGIYDALFDISSKVNASKAWNEVKRQISIATFTVQAAAETLREVA
uniprot
proteins
ec_number
3.4.17.21
uniprot
proteins
function
FUNCTION: Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides (By similarity). In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. {ECO:0000250}.; FUNCTION: Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC. {ECO:0000250}.
uniprot
proteins
mass_dalton
84574
uniprot
proteins
protein_family
M28B subfamily
uniprot
proteins
protein_family
Peptidase M28 family
uniprot
proteins
pubmed
11210180
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
752
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q04609}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q04609}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..44; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins