Tnp2
entrez
24840
canonical
uniprot
P11101
canonical
genesymbol
Tnp2
resolver
uniprot
A6K4I8
resolver
uniprot
B3LF38
resolver
uniprot
Q64390
resolver
uniprot
Q64561
resolver
uniprot
Q6AYX7
resolver
uniprot_entry
A6K4I8_RAT
resolver
uniprot_entry
STP2_RAT
resolver
uniprot_sec
B3LF38
resolver
uniprot_sec
Q64390
resolver
uniprot_sec
Q64561
resolver
uniprot_sec
Q6AYX7
resolver
amino_acid_sequence
MDTKMQSLPTTHPHPHSSSRPQSHTNNQCACSHHCRSCSQAGHPSSSSSPSPGPPTKHPKTPMHSRYSPSRPSHRGSCPKNRKTLEGKVSKRKAVRRRKRTHRAKRRSSGRRYK
uniprot
proteins
function
FUNCTION: Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals (PubMed:11772016). In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction (By similarity). {ECO:0000250|UniProtKB:P11378, ECO:0000269|PubMed:11772016}.
uniprot
proteins
mass_dalton
12848
uniprot
proteins
mutagenesis
MUTAGEN 12; /note="H->Q: 50% loss of zinc binding; when associated with Q-14; Q-16 and Q-24."; /evidence="ECO:0000269|PubMed:10961985"; MUTAGEN 14; /note="H->Q: 50% loss of zinc binding; when associated with Q-12; Q-16 and Q-24."; /evidence="ECO:0000269|PubMed:10961985"; MUTAGEN 16; /note="H->Q: 50% loss of zinc binding; when associated with Q-12; Q-14 and Q-24."; /evidence="ECO:0000269|PubMed:10961985"; MUTAGEN 24; /note="H->Q: 50% loss of zinc binding; when associated with Q-12; Q-14 and Q-16."; /evidence="ECO:0000269|PubMed:10961985"; MUTAGEN 29; /note="C->A: 50% loss of zinc binding and loss of nucleolar localization; when associated with A-31; A-35 and A-38."; /evidence="ECO:0000269|PubMed:10961985"; MUTAGEN 31; /note="C->A: 50% loss of zinc binding and loss of nucleolar localization; when associated with A-29; A-35 and A-38."; /evidence="ECO:0000269|PubMed:10961985"; MUTAGEN 35; /note="C->A: 50% loss of zinc binding and loss of nucleolar localization; when associated with A-29; A-31 and A-38."; /evidence="ECO:0000269|PubMed:10961985"; MUTAGEN 38; /note="C->A: 50% loss of zinc binding and loss of nucleolar localization; when associated with A-29; A-31 and A-35."; /evidence="ECO:0000269|PubMed:10961985"; MUTAGEN 68; /note="S->A: No effect on phosphorylation."; /evidence="ECO:0000269|PubMed:11772016"; MUTAGEN 90; /note="S->A: No effect on phosphorylation."; /evidence="ECO:0000269|PubMed:11772016"; MUTAGEN 101; /note="T->A: Slight decrease in phosphorylation."; /evidence="ECO:0000269|PubMed:11772016"; MUTAGEN 108; /note="S->A: No effect on phosphorylation."; /evidence="ECO:0000269|PubMed:11772016"; MUTAGEN 109; /note="S->A: Large decrease in phosphorylation."; /evidence="ECO:0000269|PubMed:11772016
uniprot
proteins
protein_family
Nuclear transition protein 2 family
uniprot
proteins
pubmed
10961985
uniprot
proteins
pubmed
11772016
uniprot
proteins
pubmed
14514679
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17682055
uniprot
proteins
pubmed
1930189
uniprot
proteins
pubmed
2726489
uniprot
proteins
pubmed
3307778
uniprot
proteins
pubmed
8076694
uniprot
proteins
pubmed
8720108
uniprot
proteins
pubmed
8954887
uniprot
proteins
sequence_length
114
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10961985, ECO:0000269|PubMed:14514679, ECO:0000269|PubMed:17682055}. Nucleus, nucleolus {ECO:0000269|PubMed:10961985, ECO:0000269|PubMed:14514679}. Chromosome {ECO:0000269|PubMed:14514679}. Note=Loaded onto the nucleosomes of condensing spermatids (By similarity). Nuclear import is mediated by IPO4 (PubMed:17682055). Nucleolar localization requires the protein to be phosphorylated (PubMed:14514679). {ECO:0000250|UniProtKB:P11378, ECO:0000269|PubMed:14514679, ECO:0000269|PubMed:17682055}.
uniprot
proteins