Atp8b3
entrez
67331
canonical
uniprot
Q6UQ17
canonical
ensembl
ENSMUSG00000003341
resolver
ensp
ENSMUSP00000020383
resolver
enst
ENSMUST00000020383
resolver
genesymbol
Atp8b3
resolver
uniprot_entry
AT8B3_MOUSE
resolver
amino_acid_sequence
MDGVHLGENLEDKDTEFTWEVKANDRTYHKQFKKKGFLCWRQKKYKSNAIHTAKYNIFSFLPLNLYEQFHRMSNLYFLFIIILQGIPEISTLPWFTLFAPLVCLFVIRATRDLVDDIGRHRSDKIINNRPCQILRGKSFLWKKWKNLCVGDVVCLSKDSIVPADLLLLASTEPSSLCYVETADIDGETNLKFRQALTVTHHELTSPKKMASFQGTVTCEEPNSRMHHFVGSLEWNSRKYPLDIGNLLLRGCKIRNTDTCYGLVIYAGLDTKIMKNCGKIHLKRTKLDLMMNKLVALIFLSLVIASLLLTVGFTFMVKQFKAKHYYMSPTHGRSDAMESFFIFWGFLILLSVMVPMAMFIIAEFIYLGNSIFINWDLNMYYEPLDMPAKARSTSLNDQLGQVQYIFSDKTGTLTQNIMTFKKCCINGCIYDSDDEHGTLRKRNPYAWNPFADGKLQFYNKELESLVQGRQDRAVQEFWRLLAICHTVMVQEKDNQLLYQAASPDEEALVTAARNFGYVFLSRTQDTITLVELGEERVYQVLAMMDFNSVRKRMSVLVRNPEGSICLYTKGADTVILERLRSKGVMEATTEEVLAAFAEQTLRTLCLAYKDVEEDAYKEWEPEHQEAALLLQNRAQALHQVYNKMEQNLQLLGATAIEDKLQDGVPETIKCLKKGNIKIWVLTGDKPETAVNIGFACQLLSENMIILEDKDINQVLERYWEDNVHQKAFKMMTHHNMALVINGEFLDQLLLSLRKEPRALVQNAVVDEVAQEPVVSALDFLQKRRISQMWRNAGPSLGTSHSADSKIRESPEVQRERAFVDLASKCQAVICCRVTPKQKALVVALVKKYQQVVTLAIGDGANDVNMIKTADIGVGLAGQEGMQAVQNSDYVLAQFCYLQRLLLVHGRWSYMRVCKFLRYFFYKTVASMMAQIWFSLVNGFSAQPLYEGWFLALFNLLYSTLPVLYIGLFEQDVTAEKSLKMPELYMAGQKGELFNYSIFMQAITHGTITSMINFFVTVMVSSDMSKAGSSHDYQSLGVLVAISSLLSVTLEVMLVVKYWTLLFVGAVVLSLSSYVLMTSLTQSLWMYRISPKTFPFLFADYNVLFEPCSLLLIVLNVALNVLPMLALRTIHRTVLKQRPKGEEEAPSEEVAVEPAMRHLRRGIPARRSSYAFSHREGYANLITQGTILRRQTHVDDSDGGTVCESLNPPEEDIPLQNKDSVFNPRKISILAKKRRHFFGKGSQEEVHPNTSSQTMEKQPTIHRDSETQKLPTTTSATSGKLLPSASEDEAFYSVASQYTLASQPKHTDVHSSFWKSPLWRDSASSSPSQLEVPRKQS
uniprot
proteins
ec_number
7.6.2.1
uniprot
proteins
function
FUNCTION: P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:14975727, PubMed:19017724). Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules (PubMed:14975727). May be responsible for the maintenance of asymmetric distribution of phosphatidylserine (PS) in spermatozoa membranes (PubMed:14975727). Involved in acrosome reactions and binding of spermatozoa to zona pellucida (PubMed:19017724). {ECO:0000269|PubMed:14975727, ECO:0000269|PubMed:19017724}.
uniprot
proteins
mass_dalton
151955
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type IV subfamily
uniprot
proteins
pubmed
14975727
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19017724
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
1335
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000269|PubMed:14975727, ECO:0000269|PubMed:19017724}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O60423}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 75..95; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 296..316; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 340..360; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 918..938; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 947..967; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 996..1016; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1034..1054; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1056..1076; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1105..1125; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins