CD53
entrez
963
canonical
uniprot
P19397
canonical
ensembl
ENSG00000143119
resolver
ensp
ENSP00000271324
resolver
ensp
ENSP00000497382
resolver
ensp
ENSP00000567470
resolver
ensp
ENSP00000567474
resolver
ensp
ENSP00000567475
resolver
ensp
ENSP00000567477
resolver
ensp
ENSP00000567479
resolver
ensp
ENSP00000592969
resolver
enst
ENST00000271324
resolver
enst
ENST00000648608
resolver
enst
ENST00000897411
resolver
enst
ENST00000897420
resolver
genesymbol
CD53
resolver
genesymbol_syn
MOX44
resolver
genesymbol_syn
TSPAN25
resolver
hgnc
HGNC:1686
resolver
uniprot
B2R905
resolver
uniprot
B4DQB5
resolver
uniprot
Q5U0D6
resolver
uniprot_entry
B4DQB5_HUMAN
resolver
uniprot_entry
CD53_HUMAN
resolver
uniprot_sec
B2R905
resolver
uniprot_sec
Q5U0D6
resolver
amino_acid_sequence
MGMSSLKLLKYVLFFFNLLFWICGCCILGFGIYLLIHNNFGVLFHNLPSLTLGNVFVIVGSIIMVVAFLGCMGSIKENKCLLMSFFILLLIILLAEVTLAILLFVYEQKLNEYVAKGLTDSIHRYHSDNSTKAAWDSIQSFLQCCGINGTSDWTSGPPASCPSDRKVEGCYAKARLWFHSNFLYIGIITICVCVIEVLGMSFALTLNCQIDKTSQTIGL
uniprot
proteins
function
FUNCTION: Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling (PubMed:28487417). Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking (PubMed:32974937, PubMed:35767951). Plays a role in the activation of monocytes and B-cells (PubMed:8335905). Acts as an essential regulator of B-cell development by promoting interleukin-7 receptor/IL7R signaling (By similarity). Also promotes, in B-cells, the BCR signaling by recruiting PKC to the plasma membrane in order to phosphorylate its substrates (PubMed:28487417). Plays an essential role in B- and T-cells homing to lymph nodes by stabilizing L-selectin/SELL cell surface expression (By similarity). Also mediates metabolic and inflammatory functions in hepatocytes and adipose tissue by promoting TNF and LPS signaling independent of the immune compartment (By similarity). {ECO:0000250|UniProtKB:Q61451, ECO:0000269|PubMed:28487417, ECO:0000269|PubMed:35767951, ECO:0000269|PubMed:8335905}.
uniprot
proteins
mass_dalton
24341
uniprot
proteins
mutagenesis
MUTAGEN 43; /note="L->A: About 50% loss of B-cell chemotactic activity."; /evidence="ECO:0000269|PubMed:32974937"; MUTAGEN 44; /note="F->A: About 50% loss of B-cell chemotactic activity."; /evidence="ECO:0000269|PubMed:32974937
uniprot
proteins
protein_family
Tetraspanin (TM4SF) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
1700763
uniprot
proteins
pubmed
21930792
uniprot
proteins
pubmed
2258620
uniprot
proteins
pubmed
28487417
uniprot
proteins
pubmed
32974937
uniprot
proteins
pubmed
35767951
uniprot
proteins
pubmed
8335905
uniprot
proteins
sequence_length
219
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28487417}. Cell junction {ECO:0000250|UniProtKB:Q61451}. Membrane; Multi-pass membrane protein. Synapse {ECO:0000269|PubMed:35767951}. Note=Concentrates in localized microdomains along the plasma membrane at the contact sites between cells of fused myotubes. {ECO:0000250|UniProtKB:Q61451}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 55..69; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 81..106; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 182..206; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins