Nhlrc1
entrez
364682
canonical
uniprot
Q6IMG5
canonical
ensembl
ENSRNOG00000026286
resolver
ensembl
ENSRNOG00055015894
resolver
ensembl
ENSRNOG00060021876
resolver
ensembl
ENSRNOG00065010535
resolver
ensp
ENSRNOP00000030625
resolver
ensp
ENSRNOP00055021826
resolver
ensp
ENSRNOP00060031242
resolver
ensp
ENSRNOP00065013058
resolver
enst
ENSRNOT00000031656
resolver
enst
ENSRNOT00055027030
resolver
enst
ENSRNOT00060037885
resolver
enst
ENSRNOT00065017050
resolver
genesymbol
Nhlrc1
resolver
genesymbol_syn
Epm2b
resolver
uniprot_entry
NHLC1_RAT
resolver
amino_acid_sequence
MGEEAAGVRPELVREAEVSLLECKVCFERFGHRQQRRPRNLPCGHVVCLACVAALAHPRTLALECPFCRRACRACDTSDCLPVLHLLELLGSTLHASPAALSAASCAPGALTCYHAFGGWGTLVNPTGLALCPKTGRVVVVHDGKRRVKIFDSGGGGAHQFGEKGDAAHDVKYPLDVAVTNDCHVVVTDAGDCSLKVFDFFGQIKLVVGKQFSLPWGVEITPHNGVLVTDAEAGTLHLLEADFPEGVLRRIERLQAHLCNPRGVAVSWLTGAIAVLEHPCALGTSSGNNTRVKVFNSSMQLIGQVDSFGLNLLFPSKITASAVTFDHQGNVIVADTSGPAIVCLGKPEEFPALKPMVTHGLSRPVALVFTKENSLLVLDSASHSIKVFKVMEGNGG
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway. {ECO:0000250}.
uniprot
proteins
mass_dalton
42089
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
12958597
uniprot
proteins
sequence_length
396
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250}. Nucleus {ECO:0000250}. Note=Localizes at the endoplasmic reticulum and, to a lesser extent, in the nucleus. {ECO:0000250}.
uniprot
proteins