Fkbp6
entrez
94244
canonical
uniprot
Q91XW8
canonical
ensembl
ENSMUSG00000040013
resolver
ensp
ENSMUSP00000043193
resolver
ensp
ENSMUSP00000144381
resolver
ensp
ENSMUSP00000144460
resolver
ensp
ENSMUSP00000144471
resolver
genesymbol
Fkbp6
resolver
genesymbol_syn
Fkbp36
resolver
uniprot
Q8C1Y1
resolver
uniprot
Q91VB7
resolver
uniprot
Q91Y30
resolver
uniprot_entry
FKBP6_MOUSE
resolver
uniprot_sec
Q8C1Y1
resolver
uniprot_sec
Q91VB7
resolver
uniprot_sec
Q91Y30
resolver
amino_acid_sequence
MGGSTRDPGALEGAGILGQSPYERLSQRMLDISGDRGVLKDIIREGTGDTVTPDASVLVKYSGYLEHMDKPFDSNCFRKTPRLMKLGEDITLWGMELGLLSMRKGELARFLFKPAYAYGTLGCPPLIPPNATVLFEIELIDFLDSAESDKFCALSAEQQEQFPLQKVLKVAATEREFGNYLFRQNRFCDAKVRYKRALLLLHRRLATCEEQHLVEPAVLLVLLNLSFVYLKLDRPAMALRYGEQALLIDKRNAKALFRCGQACLLLTEYERARDFLVRAQKEQPCNHDINNELKKLSSHYRDYVDREREMCHRMFAPCGSRSSVGGN
uniprot
proteins
function
FUNCTION: Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes. {ECO:0000269|PubMed:12764197, ECO:0000269|PubMed:18408354, ECO:0000269|PubMed:22902560}.
uniprot
proteins
mass_dalton
37125
uniprot
proteins
mutagenesis
MUTAGEN 254; /note="K->A: Abolishes interaction with HSP90."; /evidence="ECO:0000269|PubMed:22902560
uniprot
proteins
protein_family
FKBP6 family
uniprot
proteins
pubmed
12764197
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18408354
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22902560
uniprot
proteins
sequence_length
327
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:12764197, ECO:0000269|PubMed:22902560}. Nucleus {ECO:0000269|PubMed:12764197}. Chromosome {ECO:0000269|PubMed:12764197}. Note=Does not localize to pi-bodies. Localizes to meiotic chromosome cores and regions of homologous chromosome synapsis (synaptonemal complex). {ECO:0000269|PubMed:12764197, ECO:0000269|PubMed:22902560}.
uniprot
proteins