Id2
entrez
15902
canonical
uniprot
P41136
canonical
ensembl
ENSMUSG00000020644
resolver
ensp
ENSMUSP00000020974
resolver
ensp
ENSMUSP00000152052
resolver
enst
ENSMUST00000020974
resolver
enst
ENSMUST00000221761
resolver
genesymbol
Id2
resolver
genesymbol_syn
Id-2
resolver
genesymbol_syn
Idb2
resolver
uniprot
O88604
resolver
uniprot
Q545T4
resolver
uniprot_entry
ID2_MOUSE
resolver
uniprot_entry
Q545T4_MOUSE
resolver
uniprot_sec
O88604
resolver
amino_acid_sequence
MKAFSPVRSVRKNSLSDHSLGISRSKTPVDDPMSLLYNMNDCYSKLKELVPSIPQNKKVTKMEILQHVIDYILDLQIALDSHPTIVSLHHQRPGQNQASRTPLTTLNTDISILSLQASEFPSELMSNDSKVLCG
uniprot
proteins
function
FUNCTION: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Restricts the CLOCK and BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism. {ECO:0000269|PubMed:16556596, ECO:0000269|PubMed:19217292, ECO:0000269|PubMed:19740747, ECO:0000269|PubMed:20861012}.
uniprot
proteins
mass_dalton
14959
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated; which is favored by Ifi204 and leads to proteasomal degradation. Ubiquitinated in a ASB4-dependent manner, leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q02363}.; PTM: Phosphorylated in vitro by CDK1, PKA and PKC. {ECO:0000250|UniProtKB:P41137}.
uniprot
proteins
pubmed
11940648
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15563451
uniprot
proteins
pubmed
16556596
uniprot
proteins
pubmed
19217292
uniprot
proteins
pubmed
1922066
uniprot
proteins
pubmed
19740747
uniprot
proteins
pubmed
20861012
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9831657
uniprot
proteins
sequence_length
134
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15563451, ECO:0000269|PubMed:20861012}. Nucleus {ECO:0000269|PubMed:15563451}.
uniprot
proteins