Sox12
entrez
20667
canonical
uniprot
Q04890
canonical
ensembl
ENSMUSG00000051817
resolver
ensp
ENSMUSP00000138293
resolver
enst
ENSMUST00000182625
resolver
genesymbol
Sox12
resolver
genesymbol_syn
Sox-12
resolver
uniprot
A2AS82
resolver
uniprot
P70417
resolver
uniprot
Q6NXL2
resolver
uniprot_entry
SOX12_MOUSE
resolver
uniprot_sec
A2AS82
resolver
uniprot_sec
P70417
resolver
uniprot_sec
Q6NXL2
resolver
amino_acid_sequence
MVQQRGARAKRDGGPPPPGPGPAAEGAREPGWCKTPSGHIKRPMNAFMVWSQHERRKIMDQWPDMHNAEISKRLGRRWQLLQDSEKIPFVREAERLRLKHMADYPDYKYRPRKKSKGAPAKARPRPPGGGGGGSRLKPGPQLPGRGGRRASGGPLGGGAAAPEDDDEDEEEELLEVRLLETPGRELWRMVPAGRAARGPAERAQGPSGEGAAASAASPTLSEDEEPEEEEEEAATAEEGEEETVVSGEEPLGFLSRMPPGPAGLDCSALDRDPDLLPPSGTSHFEFPDYCTPEVTEMIAGDWRSSSIADLVFTY
uniprot
proteins
function
FUNCTION: Transcription factor that binds to DNA at the consensus sequence 5'-ACCAAAG-3' (PubMed:18403418, PubMed:18505825, PubMed:30190287). Acts as a transcriptional activator (PubMed:18403418, PubMed:18505825, PubMed:30190287). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances transcriptional activation (PubMed:18403418, PubMed:18505825). Involved in the differentiation of naive CD4-positive T-cells into peripherally induced regulatory T (pT reg) cells under inflammatory conditions (PubMed:30190287). Binds to the promoter region of the FOXP3 gene and promotes its transcription, and might thereby contribute to pT reg cell differentiation in the spleen and lymph nodes during inflammation (PubMed:30190287). Plays a redundant role with SOX4 and SOX11 in cell survival of developing tissues such as the neural tube, branchial arches and somites, thereby contributing to organogenesis (PubMed:20596238). {ECO:0000269|PubMed:18403418, ECO:0000269|PubMed:18505825, ECO:0000269|PubMed:20596238, ECO:0000269|PubMed:30190287}.
uniprot
proteins
mass_dalton
34083
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18403418
uniprot
proteins
pubmed
18505825
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20596238
uniprot
proteins
pubmed
30190287
uniprot
proteins
pubmed
8441686
uniprot
proteins
pubmed
8921394
uniprot
proteins
sequence_length
314
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
uniprot
proteins