Itga6
entrez
16403
canonical
uniprot
Q61739
canonical
ensembl
ENSMUSG00000027111
resolver
ensp
ENSMUSP00000028522
resolver
ensp
ENSMUSP00000301751
resolver
genesymbol
Itga6
resolver
uniprot
A2AU04
resolver
uniprot
Q6PEE8
resolver
uniprot
Q8CC06
resolver
uniprot_entry
ITA6_MOUSE
resolver
uniprot_entry
Q6PEE8_MOUSE
resolver
uniprot_entry
Q8CC06_MOUSE
resolver
uniprot_sec
A2AU04
resolver
amino_acid_sequence
MAVAGQLCLLYLSAGLLARLGTAFNLDTREDNVIRKSGDPGSLFGFSLAMHWQLQPEDKRLLLVGAPRAEALPLQRANRTGGLYSCDITSRGPCTRIEFDNDADPMSESKEDQWMGVTVQSQGPGGKVVTCAHRYEKRQHVNTKQESRDIFGRCYVLSQNLRIEDDMDGGDWSFCDGRLRGHEKFGSCQQGVAATFTKDFHYIVFGAPGTYNWKGIVRVEQKNNTFFDMNIFEDGPYEVGGETDHDESLVPVPANSYLGFSLDSGKGIVSKDDITFVSGAPRANHSGAVVLLKRDMKSAHLLPEYIFDGEGLASSFGYDVAVVDLNADGWQDIVIGAPQYFDRDGEVGGAVYVYINQQGKWSNVKPIRLNGTKDSMFGISVKNIGDINQDGYPDIAVGAPYDDLGKVFIYHGSPTGIITKPTQVLEGTSPYFGYSIAGNMDLDRNSYPDLAVGSLSDSVTIFRSRPVINILKTITVTPNRIDLRQKSMCGSPSGICLKVKACFEYTAKPSGYNPPISILGILEAEKERRKSGLSSRVQFRNQGSEPKYTQELTLNRQKQRACMEETLWLQENIRDKLRPIPITASVEIQEPSSRRRVNSLPEVLPILNSNEAKTVQTDVHFLKEGCGDDNVCNSNLKLEYKFGTREGNQDKFSYLPIQKGIPELVLKDQKDIALEITVTNSPSDPRNPRKDGDDAHEAKLIATFPDTLTYSAYRELRAFPEKQLSCVANQNGSQADCELGNPFKRNSSVTFYLILSTTEVTFDTTDLDINLKLETTSNQDNLAPITAKAKVVIELLLSVSGVAKPSQVYFGGTVVGEQAMKSEDEVGSLIEYEFRVINLGKPLKNLGTATLNIQWPKEISNGKWLLYLMKVESKGLEQIVCEPHNEINYLKLKESHNSRKKRELPEKQIDDSRKFSLFPERKYQTLNCSVNVRCVNIRCPLRGLDSKASLVLRSRLWNSTFLEEYSKLNYLDILLRASIDVTAAAQNIKLPHAGTQVRVTVFPSKTVAQYSGVAWWIILLAVLAGILMLALLVFLLWKCGFFKRSRYDDSIPRYHAVRIRKEEREIKDEKHMDNLEKKQWITKWNENESYS
uniprot
proteins
function
FUNCTION: Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (PubMed:8081870). Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (PubMed:10634791). Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (PubMed:8673141). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (By similarity). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (By similarity). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (By similarity). {ECO:0000250|UniProtKB:P23229, ECO:0000269|PubMed:10634791, ECO:0000269|PubMed:8081870, ECO:0000269|PubMed:8673141}.
uniprot
proteins
mass_dalton
122159
uniprot
proteins
post_translational_modification
PTM: Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1064' of isoform alpha-6X1A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand (By similarity). {ECO:0000250|UniProtKB:P23229}.; PTM: Undergoes PLAU-mediated cleavage at residues Arg-595-596-Arg in a time-dependent manner to produce processed integrin alpha-6 (alpha6p). {ECO:0000269|PubMed:11359780, ECO:0000269|PubMed:20664806}.; PTM: Palmitoylation by DHHC3 enhances stability and cell surface expression. {ECO:0000250|UniProtKB:P23229}.
uniprot
proteins
protein_family
Integrin alpha chain family
uniprot
proteins
pubmed
10634791
uniprot
proteins
pubmed
10825303
uniprot
proteins
pubmed
11359780
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20664806
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8081870
uniprot
proteins
pubmed
8673141
uniprot
proteins
sequence_length
1091
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P23229}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:P23229}; Lipid-anchor {ECO:0000250|UniProtKB:P23229}.
uniprot
proteins
transmembrane_region
TRANSMEM 1012..1037; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins