CRB3
entrez
92359
canonical
uniprot
Q9BUF7
canonical
ensembl
ENSG00000130545
resolver
ensp
ENSP00000349204
resolver
ensp
ENSP00000469707
resolver
ensp
ENSP00000472010
resolver
genesymbol
CRB3
resolver
hgnc
HGNC:20237
resolver
uniprot
A8KA91
resolver
uniprot
D6W643
resolver
uniprot
Q8N0V8
resolver
uniprot
Q8WVA0
resolver
uniprot_entry
CRUM3_HUMAN
resolver
uniprot_sec
A8KA91
resolver
uniprot_sec
D6W643
resolver
uniprot_sec
Q8N0V8
resolver
uniprot_sec
Q8WVA0
resolver
amino_acid_sequence
MANPGLGLLLALGLPFLLARWGRAWGQIQTTSANENSTVLPSSTSSSSDGNLRPEAITAIIVVFSLLAALLLAVGLALLVRKLREKRQTEGTYRPSSEEQVGARVPPTPNLKLPPEERLI
uniprot
proteins
function
FUNCTION: Involved in the establishment of cell polarity in mammalian epithelial cells (PubMed:12771187, PubMed:14718572, PubMed:23439680). Regulates the morphogenesis of tight junctions (PubMed:12771187, PubMed:14718572). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (By similarity). {ECO:0000250|UniProtKB:Q8QZT4, ECO:0000269|PubMed:12771187, ECO:0000269|PubMed:14718572, ECO:0000269|PubMed:23439680}.
uniprot
proteins
mass_dalton
12854
uniprot
proteins
mutagenesis
MUTAGEN 36; /note="N->D: Abolishes N-glycosylation. No effect on localization to the apical cell membrane."; /evidence="ECO:0000269|PubMed:12527193"; MUTAGEN 117..120; /note="Missing: Loss of interaction with PARD6A and PALS1. No effect on interaction with EPB41L5."; /evidence="ECO:0000269|PubMed:12771187, ECO:0000269|PubMed:14718572, ECO:0000269|PubMed:17920587
uniprot
proteins
pubmed
12527193
uniprot
proteins
pubmed
12771187
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14718572
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17920587
uniprot
proteins
pubmed
23439680
uniprot
proteins
sequence_length
120
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:12527193, ECO:0000269|PubMed:12771187, ECO:0000269|PubMed:14718572}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, tight junction {ECO:0000269|PubMed:12527193}. Note=Localizes primarily to the apical membrane with a small fraction in the upper part of tight junctions of epithelial cells. {ECO:0000269|PubMed:14718572}.
uniprot
proteins
transmembrane_region
TRANSMEM 60..80; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins