RNF183
entrez
138065
canonical
uniprot
Q96D59
canonical
ensembl
ENSG00000165188
resolver
ensp
ENSP00000417176
resolver
ensp
ENSP00000417943
resolver
ensp
ENSP00000419454
resolver
ensp
ENSP00000420740
resolver
ensp
ENSP00000508293
resolver
ensp
ENSP00000575401
resolver
ensp
ENSP00000575402
resolver
ensp
ENSP00000575403
resolver
ensp
ENSP00000575404
resolver
ensp
ENSP00000575405
resolver
ensp
ENSP00000575406
resolver
ensp
ENSP00000609832
resolver
ensp
ENSP00000618660
resolver
enst
ENST00000297894
resolver
enst
ENST00000416588
resolver
enst
ENST00000441031
resolver
enst
ENST00000478815
resolver
enst
ENST00000489339
resolver
enst
ENST00000905342
resolver
enst
ENST00000905343
resolver
enst
ENST00000905344
resolver
enst
ENST00000905345
resolver
enst
ENST00000905346
resolver
enst
ENST00000905347
resolver
enst
ENST00000939773
resolver
enst
ENST00000948601
resolver
genesymbol
RNF183
resolver
hgnc
HGNC:28721
resolver
uniprot_entry
RN183_HUMAN
resolver
amino_acid_sequence
MAEQQGRELEAECPVCWNPFNNTFHTPKMLDCCHSFCVECLAHLSLVTPARRRLLCPLCRQPTVLASGQPVTDLPTDTAMLALLRLEPHHVILEGHQLCLKDQPKSRYFLRQPQVYTLDLGPQPGGQTGPPPDTASATVSTPILIPSHHSLRECFRNPQFRIFAYLMAVILSVTLLLIFSIFWTKQFLWGVG
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Acts as an E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:29507230). Triggers apoptosis in response to prolonged ER stress by mediating the polyubiquitination and subsequent proteasomal degradation of BCL2L1 (PubMed:29507230). May collaborate with FATE1 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849). Mediates the ubiquitination and subsequent lysosomal degradation of ATP1B1 (By similarity). {ECO:0000250|UniProtKB:Q8QZS5, ECO:0000269|PubMed:29507230, ECO:0000305|PubMed:26567849}.
uniprot
proteins
mass_dalton
21617
uniprot
proteins
mutagenesis
MUTAGEN 13; /note="C->A: Abolishes autoubiquitination; when associated with A-59."; /evidence="ECO:0000269|PubMed:26567849"; MUTAGEN 13; /note="C->S: Loss of autoubiquitination and reduced ubiquitination of BCL2L1; when associated with S-16."; /evidence="ECO:0000269|PubMed:29507230"; MUTAGEN 16; /note="C->S: Loss of autoubiquitination and reduced ubiquitination of BCL2L1; when associated with S-13."; /evidence="ECO:0000269|PubMed:29507230"; MUTAGEN 28; /note="K->R: Loss of autoubiquitination but no effect on ubiquitination of BCL2L1; when associated with R-101 and R-105."; /evidence="ECO:0000269|PubMed:29507230"; MUTAGEN 59; /note="C->A: Abolishes autoubiquitination; when associated with A-13."; /evidence="ECO:0000269|PubMed:26567849"; MUTAGEN 101; /note="K->R: Loss of autoubiquitination but no effect on ubiquitination of BCL2L1; when associated with R-28 and R-105."; /evidence="ECO:0000269|PubMed:29507230"; MUTAGEN 105; /note="K->R: Loss of autoubiquitination but no effect on ubiquitination of BCL2L1; when associated with R-28 and R-101."; /evidence="ECO:0000269|PubMed:29507230
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:29507230}.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated (in vitro). {ECO:0000269|PubMed:26567849, ECO:0000269|PubMed:29507230}.
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
26567849
uniprot
proteins
pubmed
29300766
uniprot
proteins
pubmed
29507230
uniprot
proteins
sequence_length
192
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:29507230}; Single-pass type IV membrane protein {ECO:0000305|PubMed:29507230}. Endoplasmic reticulum {ECO:0000269|PubMed:26567849}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q8QZS5}; Single-pass type IV membrane protein {ECO:0000305|PubMed:29507230}. Lysosome membrane {ECO:0000250|UniProtKB:Q8QZS5}; Single-pass type IV membrane protein {ECO:0000305|PubMed:29507230}.
uniprot
proteins
transmembrane_region
TRANSMEM 162..182; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins