Adk
entrez
11534
canonical
uniprot
P55264
canonical
ensembl
ENSMUSG00000039197
resolver
ensp
ENSMUSP00000047665
resolver
ensp
ENSMUSP00000153089
resolver
ensp
ENSMUSP00000245097
resolver
ensp
ENSMUSP00000347603
resolver
genesymbol
Adk
resolver
uniprot
Q6JAM3
resolver
uniprot
Q8BMC5
resolver
uniprot
Q91VJ3
resolver
uniprot_entry
ADK_MOUSE
resolver
uniprot_entry
Q8BMC5_MOUSE
resolver
uniprot_sec
Q6JAM3
resolver
uniprot_sec
Q91VJ3
resolver
activity_regulation
ACTIVITY REGULATION: Activity is inhibited by 5-iodotubercidin and 5'-amino-5'-deoxyadenosine. {ECO:0000250|UniProtKB:P55263}.
uniprot
proteins
amino_acid_sequence
MAAADEPKPKKLKVEAPQALSENVLFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAEDKHKELFDELVKKFKVEYHAGGSTQNSMKVAQWLIQEPHKAATFFGCIGIDKFGEILKRKAADAHVDAHYYEQNEQPTGTCAACITGGNRSLVANLAAANCYKKEKHLDLERNWVLVEKARVYYIAGFFLTVSPESVLKVARYAAENNRVFTLNLSAPFISQFFKEALMDVMPYVDILFGNETEAATFAREQGFETKDIKEIAKKAQALPKVNSKRQRTVIFTQGRDDTIVAAENDVTAFPVLDQNQEEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASVIIRRTGCTFPEKPDFH
uniprot
proteins
ec_number
2.7.1.-
uniprot
proteins
ec_number
2.7.1.20
uniprot
proteins
function
FUNCTION: Adenosine kinase that mediates the phosphorylation of the purine nucleoside adenosine at the 5' position in an ATP-dependent manner: catalyzes phosphorylation of both unmodified and modified adenosines (PubMed:15317590, PubMed:6407470). Plays a key role in the detoxification of modified adenosines containing N(6)-methylated adenine (m6A) post-transcriptional modification (PubMed:40840445). Modified nucleosides are derived from the degradation of RNAs (mRNAs, rRNAs and tRNAs) and possess intrinsic cytotoxicity and must be cleared to prevent metabolic dysfunction (PubMed:40840445). Catalyzes the phosphorylation of the free cytosolic methylated adenosine nucleotides N(6)-methyladenosine (m6A), N(6),N(6)-dimethyladenosine (m6,6A) and N(6)-isopentenyladenosine (i6A) into adenosine monophosphate (AMP) intermediates that are further detoxified by MAPDA/ADAL (PubMed:40840445). {ECO:0000269|PubMed:15317590, ECO:0000269|PubMed:40840445, ECO:0000269|PubMed:6407470}.
uniprot
proteins
mass_dalton
40149
uniprot
proteins
mutagenesis
MUTAGEN 48; /note="S->A: No effect on in vitro phosphorylation by PKC."; /evidence="ECO:0000269|PubMed:15317590"; MUTAGEN 85; /note="S->A: No effect on in vitro phosphorylation by PKC."; /evidence="ECO:0000269|PubMed:15317590"; MUTAGEN 272; /note="S->A: No effect on in vitro phosphorylation by PKC."; /evidence="ECO:0000269|PubMed:15317590"; MUTAGEN 328; /note="S->A: No effect on in vitro phosphorylation by PKC."; /evidence="ECO:0000269|PubMed:15317590
uniprot
proteins
pathway_participation
PATHWAY: Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1. {ECO:0000250|UniProtKB:P55263}.
uniprot
proteins
protein_family
Carbohydrate kinase PfkB family
uniprot
proteins
pubmed
11997462
uniprot
proteins
pubmed
15317590
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27903722
uniprot
proteins
pubmed
40840445
uniprot
proteins
pubmed
6407470
uniprot
proteins
pubmed
8917457
uniprot
proteins
sequence_length
361
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:6407470}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000250|UniProtKB:P55263}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000250|UniProtKB:P55263}.
uniprot
proteins