Rab1b
entrez
76308
canonical
uniprot
Q9D1G1
canonical
ensembl
ENSMUSG00000024870
resolver
ensp
ENSMUSP00000025804
resolver
enst
ENSMUST00000025804
resolver
genesymbol
Rab1b
resolver
genesymbol_syn
Rab1B
resolver
uniprot
Q0PD66
resolver
uniprot
Q3U0N1
resolver
uniprot_entry
Q0PD66_MOUSE
resolver
uniprot_entry
RAB1B_MOUSE
resolver
uniprot_sec
Q3U0N1
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) including TBC1D20 which increases the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000250|UniProtKB:Q9H0U4}.
uniprot
proteins
amino_acid_sequence
MNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTESYISTIGVDFKIRTIELDGKTIKLQIWDTAGQERFRTITSSYYRGAHGIIVVYDVTDQESYANVKQWLQEIDRYASENVNKLLVGNKSDLTTKKVVDNTTAKEFADSLGVPFLETSAKNATNVEQAFMTMAAEIKKRMGPGAASGGERPNLKIDSTPVKPASGGCC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (By similarity). Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Required to modulate the compacted morphology of the Golgi. Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment (By similarity). {ECO:0000250|UniProtKB:P10536, ECO:0000250|UniProtKB:Q9H0U4}.
uniprot
proteins
mass_dalton
22187
uniprot
proteins
mutagenesis
MUTAGEN 22; /note="S->N: Increases the interaction with MTMR6."; /evidence="ECO:0000269|PubMed:23188820"; MUTAGEN 67; /note="Q->L: No effect on the interaction with MTMR6."; /evidence="ECO:0000269|PubMed:23188820
uniprot
proteins
post_translational_modification
PTM: Prenylated; by GGTase II, only after interaction of the substrate with Rab escort protein 1 (REP1). {ECO:0000250|UniProtKB:Q9H0U4}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23188820
uniprot
proteins
sequence_length
201
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H0U4}. Membrane {ECO:0000250|UniProtKB:Q9H0U4}; Lipid-anchor {ECO:0000250|UniProtKB:Q9H0U4}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9H0U4}. Preautophagosomal structure membrane {ECO:0000250|UniProtKB:Q9H0U4}; Lipid-anchor {ECO:0000250|UniProtKB:Q9H0U4}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9H0U4}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P10536}. Note=Targeted by REP1 to membranes of specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles between these two compartments. In the GDP-form, colocalizes with GDI in the cytoplasm (By similarity). Co-localizes with MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment and to the peri-Golgi region (By similarity). {ECO:0000250|UniProtKB:P10536, ECO:0000250|UniProtKB:Q9H0U4}.
uniprot
proteins