RASSF1
entrez
11186
canonical
uniprot
Q9NS23
canonical
ensembl
ENSG00000068028
resolver
ensp
ENSP00000333327
resolver
ensp
ENSP00000349547
resolver
ensp
ENSP00000352323
resolver
ensp
ENSP00000378558
resolver
ensp
ENSP00000482696
resolver
genesymbol
RASSF1
resolver
genesymbol_syn
RDA32
resolver
hgnc
HGNC:9882
resolver
uniprot
B7ZLL1
resolver
uniprot
O14571
resolver
uniprot
O60539
resolver
uniprot
O60710
resolver
uniprot
Q0VGC6
resolver
uniprot
Q5TZT2
resolver
uniprot
Q9HB04
resolver
uniprot
Q9HB18
resolver
uniprot
Q9NS22
resolver
uniprot
Q9UND4
resolver
uniprot
Q9UND5
resolver
uniprot_entry
RASF1_HUMAN
resolver
uniprot_sec
B7ZLL1
resolver
uniprot_sec
O14571
resolver
uniprot_sec
O60539
resolver
uniprot_sec
O60710
resolver
uniprot_sec
Q0VGC6
resolver
uniprot_sec
Q5TZT2
resolver
uniprot_sec
Q9HB04
resolver
uniprot_sec
Q9HB18
resolver
uniprot_sec
Q9NS22
resolver
uniprot_sec
Q9UND4
resolver
uniprot_sec
Q9UND5
resolver
amino_acid_sequence
MSGEPELIELRELAPAGRAGKGRTRLERANALRIARGTACNPTRQLVPGRGHRFQPAGPATHTWCDLCGDFIWGVVRKGLQCARLSADCKFTCHYRCRALVCLDCCGPRDLGWEPAVERDTNVDEPVEWETPDLSQAEIEQKIKEYNAQINSNLFMSLNKDGSYTGFIKVQLKLVRPVSVPSSKKPPSLQDARRGPGRGTSVRRRTSFYLPKDAVKHLHVLSRTRAREVIEALLRKFLVVDDPRKFALFERAERHGQVYLRKLLDDEQPLRLRLLAGPSDKALSFVLKENDSGEVNWDAFSMPELHNFLRILQREEEEHLRQILQKYSYCRQKIQEALHACPLG
uniprot
proteins
function
FUNCTION: Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage. {ECO:0000269|PubMed:10888881, ECO:0000269|PubMed:11333291, ECO:0000269|PubMed:12024041, ECO:0000269|PubMed:14743218, ECO:0000269|PubMed:15109305, ECO:0000269|PubMed:15949439, ECO:0000269|PubMed:16510573, ECO:0000269|PubMed:18566590, ECO:0000269|PubMed:21199877}.
uniprot
proteins
mass_dalton
39219
uniprot
proteins
pubmed
10888881
uniprot
proteins
pubmed
11333291
uniprot
proteins
pubmed
11857081
uniprot
proteins
pubmed
12024041
uniprot
proteins
pubmed
14729613
uniprot
proteins
pubmed
14743218
uniprot
proteins
pubmed
15109305
uniprot
proteins
pubmed
15205320
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15753381
uniprot
proteins
pubmed
15949439
uniprot
proteins
pubmed
16510573
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
18566590
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
21134643
uniprot
proteins
pubmed
21199877
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
344
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform A]: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Nucleus. Note=Localizes to cytoplasmic microtubules during interphase, to bipolar centrosomes associated with microtubules during prophase, to spindle fibers and spindle poles at metaphase and anaphase, to the midzone during early telophase, and to the midbody in late telophase in cells. Colocalizes with MDM2 in the nucleus.; SUBCELLULAR LOCATION: [Isoform C]: Nucleus. Note=Predominantly nuclear.
uniprot
proteins