Plekhm1
entrez
303584
canonical
uniprot
Q5PQS0
canonical
ensembl
ENSRNOG00000028521
resolver
ensembl
ENSRNOG00055030835
resolver
ensembl
ENSRNOG00060013474
resolver
ensembl
ENSRNOG00065028040
resolver
ensp
ENSRNOP00000034752
resolver
ensp
ENSRNOP00000106445
resolver
ensp
ENSRNOP00055044246
resolver
ensp
ENSRNOP00060018198
resolver
ensp
ENSRNOP00065039704
resolver
enst
ENSRNOT00000037147
resolver
enst
ENSRNOT00000150646
resolver
enst
ENSRNOT00055053521
resolver
enst
ENSRNOT00060022980
resolver
enst
ENSRNOT00065048400
resolver
genesymbol
Plekhm1
resolver
uniprot
A0ABK0LL38
resolver
uniprot_entry
A0ABK0LL38_RAT
resolver
uniprot_entry
PKHM1_RAT
resolver
amino_acid_sequence
MLSVENGLDPRAAIQVIKKKLVGSVKALQKQHVSLDTVVTSEDGDANTMCSALEAVFIHGLHAKYIRAEAGGKRKKHTHQKPLPQPVFWPLLKAVTHKHIISDLEHLVFINTDVGRCRAWLRLALNDGLMECYLKLLLQEPARLCEYYQPTALLRDAEEAEFLLSFLQGLTSLSFELSYKSAILNEWTLTPLSLSGLCPLSELDPLTVSGAELQRKESLDSISHSSGSEDIEVQHSGHKIRRDRKLTASSLSLDTASSSQLSCSLNSDSCLLQENGPKSPDHSEEPMSYDSDLGTANADDSDRSLQEVLSEFSKAQVNSAPSSGPSQESDTPMFQTPLSLHSLANSTHLLFEGSEEPFPAHTSSGTSSGHKHQPQESPDMQPLGTAQAGPAGSTSDQQPSSPVAGAADQGSEPWKALEYGRVGPKLVVSSPTSPKGKSWISEDDFCRPPKEHALKNTSDLCISPLQGTPELRTALHGPFSQGPRKSCSLGALDKACVSSLDYRNAQTAPSPAVTQDHKNFCVVHRRQMGLSNPFRGLMKLGTVARRGAMGIWKEFFCELSPLELRLYLSDEERTCVESCSLLRCEAVGPAHSDGRFELVFSGKKLALRASSQDEAEDWLDRVREALQKVRPQQEEEWVNIQYPDQAEDSPEAPPDNLPPYSALLPEHAGAQGIQPNWTSAQVPEPDAIKESLLYLYADRTWIPYIFSLSLESLKCFRVRNNEKMLSDSHGVETIRDILPDTSLGGPAFFKIITAKAVLKLQAKNTEEAAHWRDLVRKVLASYLESVQEAVTLAGSLDENCQEVLKFATRENGFLLQYLVAIPTEKGLDSQGCFCAGCSRQIGFSFVRPKLCAFSGLYYCDFCHQDDASVIPARIIHNWDLTKRPVCRQALKFLAQIRAQPLINLQLVNASLYEHVERMHLIGRSREQLKLLGDYLGLCRSGALKELSKRLSHRNYLLESPHKFSVADLQQIAEGVYEGFLKALIEFASQHVYHCDLCTQRGFICQICHHQDIIFPFEFDTTVRCAECRTVFHQSCQAVVRKGCPRCARRRKYQEQNTVS
uniprot
proteins
function
FUNCTION: Acts as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Acts as a dual effector of RAB7A and ARL8B that simultaneously binds these GTPases, bringing about clustering and fusion of late endosomes and lysosomes. Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Interaction with Arl8b is a crucial factor in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion (By similarity). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (PubMed:17404618). May be involved in negative regulation of endocytic transport from early endosome to late endosome/lysosome implicating its association with Rab7. May have a role in sialyl-lex-mediated transduction of apoptotic signals (By similarity). Involved in bone resorption (By similarity). {ECO:0000250|UniProtKB:Q7TSI1, ECO:0000250|UniProtKB:Q9Y4G2, ECO:0000269|PubMed:17404618}.
uniprot
proteins
mass_dalton
117508
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17404618
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
1059
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Autolysosome membrane {ECO:0000250|UniProtKB:Q9Y4G2}. Endosome membrane {ECO:0000250|UniProtKB:Q9Y4G2}. Late endosome membrane {ECO:0000250|UniProtKB:Q9Y4G2}. Lysosome membrane {ECO:0000250|UniProtKB:Q9Y4G2}. Note=In case of infection colocalizes with Salmonella typhimurium sifA in proximity of Salmonella-containing vacuole (SCV). {ECO:0000250|UniProtKB:Q9Y4G2}.
uniprot
proteins