Coro1c
entrez
23790
canonical
uniprot
Q9WUM4
canonical
ensembl
ENSMUSG00000004530
resolver
ensp
ENSMUSP00000004646
resolver
enst
ENSMUST00000004646
resolver
genesymbol
Coro1c
resolver
uniprot
Q499X7
resolver
uniprot
Q8VCQ5
resolver
uniprot_entry
COR1C_MOUSE
resolver
uniprot_sec
Q499X7
resolver
uniprot_sec
Q8VCQ5
resolver
amino_acid_sequence
MRRVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPRFVAIIIEASGGGAFLVLPLHKTGRIDKSYPTVCGHTGPVLDIDWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLTEPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWNVGTGEALINLDDMHSDMIYNVSWSRNGSLICTASKDKKVRVIDPRKQEIVAEKEKAHEGARPMRAIFLADGNVFTTGFSRMSERQLALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESPYVHYLNTFSSKEPQRGMGYMPKRGLDVNKCEIARFFKLHERKCEPIIMTVPRKSDLFQDDLYPDTAGPEAALEAEEWFEGKNADPILISLKHGYIPGKNRDLKVVKKNILDSKPAANKKSELSCAPKKPTDTASVQNEAKLDEILKEIKSIKETICSQDERISKLEQQLAKMAA
uniprot
proteins
function
FUNCTION: Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25925950). Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments (PubMed:27178841). Required for normal cell proliferation, cell migration, and normal formation of lamellipodia (PubMed:27178841). Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission. Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane (By similarity). Required for normal distribution of mitochondria within cells (PubMed:27178841). Interacts with GDP-bound RAB44 in bone marrow macrophages to promote osteoclastogenesis (PubMed:35743062). Involved in the migration and chemotaxis of macrophages (PubMed:35743062). {ECO:0000250|UniProtKB:Q9ULV4, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:25925950, ECO:0000269|PubMed:27178841, ECO:0000269|PubMed:35743062}.
uniprot
proteins
mass_dalton
53121
uniprot
proteins
mutagenesis
MUTAGEN 28; /note="R->D: Decreased actin-binding. Loss of actin binding; when associated with 418-E-E-419 and 427-E-E-428."; /evidence="ECO:0000269|PubMed:22364218"; MUTAGEN 418..419; /note="KK->EE: Decreased actin-binding. Loss of actin binding; when associated with D-28 and 427-E-E-428."; /evidence="ECO:0000269|PubMed:22364218"; MUTAGEN 427..428; /note="KK->EE: Decreased actin-binding. Loss of actin binding; when associated with D-28 and 418-E-E-419."; /evidence="ECO:0000269|PubMed:22364218
uniprot
proteins
protein_family
WD repeat coronin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19651142
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22364218
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
25074804
uniprot
proteins
pubmed
25925950
uniprot
proteins
pubmed
27178841
uniprot
proteins
pubmed
35743062
uniprot
proteins
pubmed
9778037
uniprot
proteins
sequence_length
474
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19651142, ECO:0000269|PubMed:22364218, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:25925950}; Peripheral membrane protein {ECO:0000269|PubMed:19651142, ECO:0000269|PubMed:22364218, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:25925950}; Cytoplasmic side {ECO:0000269|PubMed:19651142, ECO:0000269|PubMed:22364218, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:25925950}. Cell projection, lamellipodium {ECO:0000269|PubMed:22364218, ECO:0000269|PubMed:27178841}. Cell projection, ruffle membrane {ECO:0000269|PubMed:25074804}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19651142, ECO:0000269|PubMed:22364218, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:27178841}. Cytoplasm, cell cortex {ECO:0000269|PubMed:19651142, ECO:0000269|PubMed:22364218}. Endosome membrane {ECO:0000250|UniProtKB:Q9ULV4}. Note=Colocalizes with the actin cytoskeleton in the cytosol, and especially in the cell cortex (PubMed:19651142, PubMed:22364218, PubMed:25074804, PubMed:27178841). Colocalizes with F-actin at the leading edge of lamellipodia (PubMed:22364218). Partially colocalizes with microtubules and vimentin intermediate filaments (PubMed:27178841). Localizes to endosome membrane tubules/buds (By similarity). {ECO:0000250|UniProtKB:Q9ULV4, ECO:0000269|PubMed:19651142, ECO:0000269|PubMed:22364218, ECO:0000269|PubMed:25074804, ECO:0000269|PubMed:27178841}.
uniprot
proteins