GK2
entrez
2712
canonical
uniprot
Q14410
canonical
ensembl
ENSG00000196475
resolver
ensp
ENSP00000351706
resolver
enst
ENST00000358842
resolver
genesymbol
GK2
resolver
genesymbol_syn
GKP2
resolver
genesymbol_syn
GKTA
resolver
hgnc
HGNC:4291
resolver
uniprot
A0A140VKG0
resolver
uniprot
A8K876
resolver
uniprot
Q6PD73
resolver
uniprot
Q86XV8
resolver
uniprot_entry
A0A140VKG0_HUMAN
resolver
uniprot_entry
GLPK2_HUMAN
resolver
uniprot_sec
A8K876
resolver
uniprot_sec
Q6PD73
resolver
uniprot_sec
Q86XV8
resolver
amino_acid_sequence
MAAPKTAAVGPLVGAVVQGTNSTRFLVFNSKTAELLSHHKVELTQEFPKEGWVEQDPKEILQSVYECIARTCEKLDELNIDISNIKAVGVSNQRETTVIWDKLTGEPLYNAVVWLDLRTQTTVEDLSKKIPGNSNFVKSKTGLPLSTYFSAVKLRWMLDNVRNVQKAVEEGRALFGTIDSWLIWSLTGGVNGGVHCTDVTNASRTMLFNIHSLEWDKELCDFFEIPMDLLPNVFSSSEIYGLIKTGALEGVPISGCLGDQCAALVGQMCFQEGQAKNTYGTGCFLLCNTGRKCVFSEHGLLTTVAYKLGREKPAYYALEGSVAIAGAVIRWLRDNLGIIETSGDIERLAKEVGTSYGCYFVPAFSGLYAPYWEPSARGILCGLTQFTNKCHIAFAALEAVCFQTREILEAMNRDCGIPLRHLQVDGGMTNNKVLMQLQADILHIPVIKPFMPETTALGAAMAAGAAEGVSVWSLEPQALSVLRMERFEPQIQATESEIRYATWKKAVMKSMGWVTSQSPEGGDPSIFSSLPLGFFIVSSMVMLIGARYISGVP
uniprot
proteins
ec_number
2.7.1.30
uniprot
proteins
function
FUNCTION: Key enzyme in the regulation of glycerol uptake and metabolism. Essential for male fertility and sperm mitochondrial sheath formation (By similarity). Required for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during spermatogenesis (By similarity). Can induce mitochondrial clustering through interactions with PLD6 and up-regulation of phosphatidic acid synthesis in the mitochondria (PubMed:28852571). {ECO:0000250|UniProtKB:Q9WU65, ECO:0000269|PubMed:28852571}.
uniprot
proteins
mass_dalton
60594
uniprot
proteins
pathway_participation
PATHWAY: Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
uniprot
proteins
protein_family
FGGY kinase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
28852571
uniprot
proteins
pubmed
33536340
uniprot
proteins
pubmed
7987308
uniprot
proteins
sequence_length
553
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9WU65}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q9WU65}. Cytoplasm {ECO:0000250}. Note=In sperm the majority of the enzyme is bound to mitochondria. {ECO:0000250|UniProtKB:Q9WU65}.
uniprot
proteins
transmembrane_region
TRANSMEM 526..546; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins