Ptp4a3
entrez
19245
canonical
uniprot
Q9D658
canonical
ensembl
ENSMUSG00000059895
resolver
ensp
ENSMUSP00000060956
resolver
ensp
ENSMUSP00000131036
resolver
ensp
ENSMUSP00000131281
resolver
ensp
ENSMUSP00000132097
resolver
ensp
ENSMUSP00000154829
resolver
ensp
ENSMUSP00000232707
resolver
ensp
ENSMUSP00000232715
resolver
ensp
ENSMUSP00000232720
resolver
ensp
ENSMUSP00000232721
resolver
ensp
ENSMUSP00000346307
resolver
enst
ENSMUST00000053232
resolver
enst
ENSMUST00000163582
resolver
enst
ENSMUST00000165541
resolver
enst
ENSMUST00000167582
resolver
enst
ENSMUST00000230177
resolver
genesymbol
Ptp4a3
resolver
genesymbol_syn
Prl3
resolver
uniprot
E9PXS4
resolver
uniprot
O70275
resolver
uniprot
Q3T9Z5
resolver
uniprot
Q9CTC8
resolver
uniprot_entry
E9PXS4_MOUSE
resolver
uniprot_entry
TP4A3_MOUSE
resolver
uniprot_sec
O70275
resolver
uniprot_sec
Q3T9Z5
resolver
uniprot_sec
Q9CTC8
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by sodium orthovanadate and peroxovanadium compounds, and by pentamidine. {ECO:0000269|PubMed:15161639}.
uniprot
proteins
amino_acid_sequence
MARMNRPAPVEVSYRHMRFLITHNPSNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLLKAKFYNDPGSCVAVHCVAGLGRAPVLVALALIESGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPKQRLRFKDPHTHKTRCCVM
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. {ECO:0000269|PubMed:15161639}.
uniprot
proteins
mass_dalton
19652
uniprot
proteins
mutagenesis
MUTAGEN 72; /note="D->A: Loss of enzymatic activity; reduced migration-promoting activity."; /evidence="ECO:0000269|PubMed:15161639"; MUTAGEN 104; /note="C->S: Loss of enzymatic activity; reduced migration-promoting activity."; /evidence="ECO:0000269|PubMed:15161639
uniprot
proteins
post_translational_modification
PTM: Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus.
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
10747914
uniprot
proteins
pubmed
15161639
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15673457
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9514946
uniprot
proteins
sequence_length
173
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane. Early endosome.
uniprot
proteins