RHOQ
entrez
23433
canonical
uniprot
P17081
canonical
ensembl
ENSG00000119729
resolver
ensp
ENSP00000238738
resolver
ensp
ENSP00000572982
resolver
ensp
ENSP00000723433
resolver
enst
ENST00000238738
resolver
genesymbol
HEL-S-42
resolver
genesymbol
RHOQ
resolver
genesymbol_syn
ARHQ
resolver
genesymbol_syn
RASL7A
resolver
genesymbol_syn
RHOQ
resolver
genesymbol_syn
TC10
resolver
hgnc
HGNC:17736
resolver
uniprot
D6W5A6
resolver
uniprot
Q0VGN1
resolver
uniprot
Q52LS8
resolver
uniprot
Q53SJ1
resolver
uniprot
Q6NS39
resolver
uniprot
Q6P146
resolver
uniprot
Q7Z480
resolver
uniprot
V9HWD0
resolver
uniprot_entry
RHOQ_HUMAN
resolver
uniprot_entry
V9HWD0_HUMAN
resolver
uniprot_sec
D6W5A6
resolver
uniprot_sec
Q0VGN1
resolver
uniprot_sec
Q52LS8
resolver
uniprot_sec
Q53SJ1
resolver
uniprot_sec
Q6NS39
resolver
uniprot_sec
Q6P146
resolver
uniprot_sec
Q7Z480
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase.
uniprot
proteins
amino_acid_sequence
MAHGPGALMLKCVVVGDGAVGKTCLLMSYANDAFPEEYVPTVFDHYAVSVTVGGKQYLLGLYDTAGQEDYDRLRPLSYPMTDVFLICFSVVNPASFQNVKEEWVPELKEYAPNVPFLLIGTQIDLRDDPKTLARLNDMKEKPICVEQGQKLAKEIGACCYVECSALTQKGLKTVFDEAIIAILTPKKHTVKKRIGSRCINCCLIT
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia. {ECO:0000269|PubMed:15546864}.
uniprot
proteins
mass_dalton
22659
uniprot
proteins
mutagenesis
MUTAGEN 23; /note="T->N: Loss of interaction with GOPC."; /evidence="ECO:0000269|PubMed:11162552"; MUTAGEN 44; /note="D->A: Loss of interaction with GOPC."; /evidence="ECO:0000269|PubMed:11162552"; MUTAGEN 67; /note="Q->L: Constitutively active. Interacts with PARD6 proteins and GOPC."; /evidence="ECO:0000269|PubMed:10934474
uniprot
proteins
post_translational_modification
PTM: May be post-translationally modified by both palmitoylation and polyisoprenylation.
uniprot
proteins
protein_family
Rho family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10490598
uniprot
proteins
pubmed
10934474
uniprot
proteins
pubmed
11162552
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15546864
uniprot
proteins
pubmed
16246732
uniprot
proteins
pubmed
2108320
uniprot
proteins
sequence_length
205
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15546864}. Cell membrane {ECO:0000269|PubMed:15546864}; Lipid-anchor {ECO:0000269|PubMed:15546864}.
uniprot
proteins