P52188
uniprot
P52188
canonical
activity_regulation
ACTIVITY REGULATION: Activated by phosphatidylinositol 4,5-biphosphate (PtdIns(4,5)P2) (By similarity). PtdIns(4,5)P2 binding to the cytoplasmic side of the channel triggers a conformation change leading to channel opening (By similarity). Inhibited by Ba(2+) (PubMed:8137958). {ECO:0000250|UniProtKB:F1NHE9, ECO:0000250|UniProtKB:Q14500, ECO:0000269|PubMed:8137958}.
uniprot
proteins
amino_acid_sequence
MTAASRANPYSIVSSEEDGLHLVTMSGANGFGNGKVHTRRRCRNRFVKKNGQCNIEFANMDEKSQRYLADMFTTCVDIRWRYMLLIFSLAFLASWLLFGIIFWVIAVAHGDLEPAEGRGRTPCVLQVHGFMAAFLFSIETQTTIGYGLRCVTEECPVAVFMVVAQSIVGCIIDSFMIGAIMAKMGRPKKRAQTLLFSHNAVVALRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPRVTEEGEYIPLDQIDIDVGFDKGLDRIFLVSPITILHEIDEASPLFGISRQDLETDDFEIVVILEGMVEATAMTTQARSSYLANEILWGHRFEPVLFEEKNQYKIDYSHFHKTYEVPSTPRCSAKDLVENKFLLPSANSFCYENELAFLSRDEEDEVATDRDGRSPQPEHDFDRLQASSGALERPYRRESEI
uniprot
proteins
function
FUNCTION: Inward rectifying potassium channel that probably participates in controlling the resting membrane potential in electrically excitable cells (By similarity). It probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues (By similarity). Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. {ECO:0000250|UniProtKB:Q14500, ECO:0000269|PubMed:14960569, ECO:0000269|PubMed:8137958}.
uniprot
proteins
mass_dalton
48399
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ12 subfamily
uniprot
proteins
pubmed
14960569
uniprot
proteins
pubmed
21209095
uniprot
proteins
pubmed
8137958
uniprot
proteins
sequence_length
427
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:21209095}. Cell membrane, sarcolemma, T-tubule {ECO:0000269|PubMed:21209095}.
uniprot
proteins
transmembrane_region
TRANSMEM 78..104; /note="Helical; Name=M1"; /evidence="ECO:0000250|UniProtKB:F1NHE9"; TRANSMEM 156..183; /note="Helical; Name=M2"; /evidence="ECO:0000250|UniProtKB:F1NHE9
uniprot
proteins