Gpr108
entrez
78308
canonical
uniprot
Q91WD0
canonical
ensembl
ENSMUSG00000005823
resolver
ensp
ENSMUSP00000005975
resolver
ensp
ENSMUSP00000156910
resolver
genesymbol
Gpr108
resolver
genesymbol_syn
Lustr2
resolver
uniprot
Q8BXE9
resolver
uniprot
Q925B1
resolver
uniprot_entry
GP108_MOUSE
resolver
uniprot_sec
Q8BXE9
resolver
uniprot_sec
Q925B1
resolver
amino_acid_sequence
MAVSERRGLSGESPTQCRWGYLSLLVLTLSGCSGRIHRLTLTGEKRADIQLNSFGFYTNGSLEVELSLLRLSLQETEKKLPKVGFSLSRVRSGSVRSYSRRNSHECPLDRNSSNFLVLFLINIKDLQVQVRKYGEQKLFISPGLLPEAPTQSGPPKPDPAGTPKDNHVIHPSPTEMSAVKENQTAPQVSGDKTTPGEHRHSSERQPPTQDPSGKEKDQVLGLGHLNDSYNFSFHIVISSRAEEGQYSLNFHNCHNSIPGQEQPFDLTVMIREKNPEGFLSAAEIPLFKLYLIMSACFLAADIFWVSVLCKNTYSVFKIHWLMAALAFTKSVSLLFHSINYYFINSQGHPIEGLAVMHYITHLLKGALLFITIALIGSGWAFVKYMLSDKEKKIFGIVIPLQVLANVAYIVIESREEGASDYGLWKEILFLVDLICCGAILFPVVWSIRHLQDASGTDGKVAVNLARLKLFRHYYVMVICYIYFTRIIAILLQVAVPFQWQWLYQLLVESSTLAFFVLTGYKFQPAGDNPYLQLPQEDEEDVQMEQVMTDSGFREGLSKVNKTASGRELL
uniprot
proteins
function
FUNCTION: May play a role in intracellular immune modulation by activating NF-kappaB response and attenuating Toll-like-receptor response. {ECO:0000269|PubMed:30332431}.; FUNCTION: (Microbial infection) Plays an essential function in adeno-associated virus (AAV) transduction, across multiple serotypes except AAV5. May play a critical role in mediating the endosomal virus escape or in the AAV virions trafficking from endosomes to the nucleus. {ECO:0000269|PubMed:31784416}.
uniprot
proteins
mass_dalton
63981
uniprot
proteins
protein_family
LU7TM family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17454009
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30332431
uniprot
proteins
pubmed
31784416
uniprot
proteins
sequence_length
569
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:30332431}; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:31784416}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus membrane; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with TLR3, -7, -4, and -9. {ECO:0000269|PubMed:30332431}.
uniprot
proteins
transmembrane_region
TRANSMEM 289..309; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 318..338; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 362..382; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 393..413; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 427..447; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 475..495; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 499..519; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins