Rbmx
entrez
302855
canonical
uniprot
Q4V898
canonical
ensembl
ENSRNOG00000000866
resolver
ensembl
ENSRNOG00055026346
resolver
ensembl
ENSRNOG00060022474
resolver
ensembl
ENSRNOG00065028909
resolver
ensp
ENSRNOP00000001154
resolver
ensp
ENSRNOP00055037251
resolver
ensp
ENSRNOP00060032282
resolver
ensp
ENSRNOP00065041010
resolver
enst
ENSRNOT00000001154
resolver
enst
ENSRNOT00055045454
resolver
enst
ENSRNOT00060039045
resolver
enst
ENSRNOT00065049929
resolver
genesymbol
Rbmx
resolver
genesymbol_syn
Rbmxrt
resolver
uniprot_entry
RBMX_RAT
resolver
amino_acid_sequence
MVEADRPGKLFIGGLNTETNEKALEAVFGKYGRIVEVLLMKDRETNKSRGFAFVTFESPADAKDAARDMNGKSLDGKAIKVEQATKPSFESGRRGLPPPPRSRGPPRGLRGGRGGSGGTRGPPSRGGHMDDGGYSMNFTLSSSRGPLPVKRGPPPRSGGPPPKRSAPSGPVRSSSGMGGRAPVSRGRDGYGGPPRREPLPSRRDVYLSPRDDGYSTKDSYSSRDYPSSRDTRDYAPPPRDYTYRDYGHSSSRDDYPSRGYSDRDGYGRERDYSDHPSGGSYRDSYESYGNSRSAPPTRGPPPSYGGSSRYDDYSSSRDGYGGSRDSYTSSRSDLYSSGRDRVGRQERGLPPSMERGYPPPRDSYSSSSRGAPRGGGRGGSRSDRGGRSRY
uniprot
proteins
function
FUNCTION: RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:17188681, ECO:0000269|PubMed:19282290}.
uniprot
proteins
mass_dalton
42258
uniprot
proteins
post_translational_modification
PTM: O-glycosylated. {ECO:0000250}.; PTM: Arg-182 is dimethylated, probably to asymmetric dimethylarginine. {ECO:0000250}.
uniprot
proteins
pubmed
15009664
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16128803
uniprot
proteins
pubmed
17188681
uniprot
proteins
pubmed
19282290
uniprot
proteins
sequence_length
390
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Component of ribonucleosomes (By similarity). Localizes in numerous small granules in the nucleus. {ECO:0000250}.
uniprot
proteins