Capn1
entrez
29153
canonical
uniprot
P97571
canonical
ensembl
ENSRNOG00000020935
resolver
ensembl
ENSRNOG00055021953
resolver
ensembl
ENSRNOG00060032465
resolver
ensembl
ENSRNOG00065033912
resolver
ensp
ENSRNOP00000112486
resolver
ensp
ENSRNOP00055030736
resolver
ensp
ENSRNOP00060046447
resolver
ensp
ENSRNOP00065047913
resolver
enst
ENSRNOT00055037693
resolver
enst
ENSRNOT00060056241
resolver
enst
ENSRNOT00065058236
resolver
genesymbol
Capn1
resolver
genesymbol_syn
Cls1
resolver
uniprot_entry
CAN1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by micromolar concentrations of calcium and inhibited by calpastatin. {ECO:0000250|UniProtKB:P07384}.
uniprot
proteins
amino_acid_sequence
MAEELITPVYCTGVSAQVQKQRDKELGLGRHENAIKYLGQDYENLRARCLQNGVLFQDDAFPPVSHSLGFKELGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNETILHRVVPYGQSFQEGYAGIFHFQLWQFGEWVDVVVDDLLPTKDGKLVFVHSAQGNEFWSALLEKAYAKVNGSYEALSGGCTSEAFEDFTGGVTEWYDLQKAPSDLYQIILKALERGSLLGCSINISDIRDLEAITFKNLVRGHAYSVTDAKQVTYQGQRVNLIRMRNPWGEVEWKGPWSDNSYEWNKVDPYEREQLRVKMEDGEFWMSFRDFIREFTKLEICNLTPDALKSRTLRNWNTTFYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLEEVDDADDYDSRESGCSFLLALMQKHRRRERRFGRDMETIGFAVYQVPRELAGQPVHLKRDFFLANASRAQSEHFINLREVSNRIRLPPGEYIVVPSTFEPNKEGDFLLRFFSEKKAGTQELDDQIQANLPDEKVLSEEEIDDNFKTLFSKLAGDDMEISVKELQTILNRIISKHKDLRTNGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLTIFRKFDLDKSGSMSAYEMRMAIEAAGFKLNKKLHELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKILDTDLDGVVTFDLFKWLQLTMFA
uniprot
proteins
ec_number
3.4.22.52
uniprot
proteins
function
FUNCTION: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves CTBP1 at 'Asn-364', 'Gly-377' and 'His-399'. Cleaves and activates caspase-7 (CASP7). {ECO:0000250|UniProtKB:P07384}.
uniprot
proteins
mass_dalton
82119
uniprot
proteins
post_translational_modification
PTM: Undergoes calcium-induced successive autoproteolytic cleavages that generate a membrane-bound 78 kDa active form and an intracellular 75 kDa active form. Calpastatin reduces with high efficiency the transition from 78 kDa to 75 kDa calpain forms (By similarity). {ECO:0000250|UniProtKB:P07384}.
uniprot
proteins
protein_family
Peptidase C2 family
uniprot
proteins
pubmed
11893336
uniprot
proteins
pubmed
14656436
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15491615
uniprot
proteins
pubmed
8950173
uniprot
proteins
sequence_length
713
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P07384}. Cell membrane {ECO:0000250|UniProtKB:P07384}. Note=Translocates to the plasma membrane upon Ca(2+) binding. {ECO:0000250|UniProtKB:P07384}.
uniprot
proteins