Fbxl4
entrez
269514
canonical
uniprot
Q8BH70
canonical
ensembl
ENSMUSG00000040410
resolver
ensp
ENSMUSP00000042219
resolver
ensp
ENSMUSP00000139158
resolver
ensp
ENSMUSP00000164934
resolver
ensp
ENSMUSP00000164935
resolver
ensp
ENSMUSP00000164949
resolver
enst
ENSMUST00000039234
resolver
enst
ENSMUST00000184582
resolver
genesymbol
Fbxl4
resolver
uniprot
V9GXH8
resolver
uniprot_entry
FBXL4_MOUSE
resolver
uniprot_entry
V9GXH8_MOUSE
resolver
amino_acid_sequence
MSPVFPMLTVLTMFYYMCLRRRARTATRGDMMNSHRTIVSNSRTSPLNAEVVQYAKEVVDFSSHYGSENSMSYTMWNLAGVPNVFPSSGDFTQTAVFRTYGTWWDQCPSASLPFRRTPSSFQSQDYVELTFEQQVYPTAVHVLETYHPGAVIRILACSANPYSPNPPAEVRWEILWSERPMKVNASQARQFKPCIKQINFPTNLIRLEVNSSLLDYYTELDAVVLHGTKDKPLLSLKTALVDMNDLEDDDYEEKDGCEMDALNKKFSSAALGDGPHNGYFDKLPYELIQLILNHLSLPDLCRLAQTCRLLHQHCCDPLQYIHLNLQPYWARLDDTSLEFLQARCVLVQWLNLSWTGNRGFISVSGFSRFLKVCGSELVRLELSCSHFLNDTCLEVISEMCPNLQDLNLSSCDKLPPQAFGHIAKLCSLKRLVLYRTKVEQTALLSILNFCAELQHLSLGSCVMIEDYDVIASMIGAKCKNLRTLDLWRCKNITENGIAELASGCVLLEELDLGWCPTLQSSTGCFVRLARQLPNLQKLFLTANRSVCDTDIEELASNCTRLQQLDILGTRMVSPASLRKLLESCKDLSLLDVSFCSQIDNKAVLELNASFPKVFIKKSFTQ
uniprot
proteins
function
FUNCTION: Substrate-recognition component of the mitochondria-localized SCF-FBXL4 ubiquitin E3 ligase complex that plays a role in the restriction of mitophagy by controlling the degradation of BNIP3 and NIX mitophagy receptors (PubMed:36896912). Also rescues mitochondrial injury through reverting hyperactivation of DRP1-mediated mitochondrial fission (PubMed:38359748). {ECO:0000269|PubMed:36896912, ECO:0000269|PubMed:38359748}.
uniprot
proteins
mass_dalton
70269
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
36896912
uniprot
proteins
pubmed
38359748
uniprot
proteins
sequence_length
621
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UKA2}. Nucleus {ECO:0000250|UniProtKB:Q9UKA2}. Mitochondrion outer membrane {ECO:0000269|PubMed:38359748}.
uniprot
proteins