Nudt1
entrez
17766
canonical
uniprot
P53368
canonical
ensembl
ENSMUSG00000036639
resolver
ensp
ENSMUSP00000059983
resolver
ensp
ENSMUSP00000071778
resolver
ensp
ENSMUSP00000106450
resolver
ensp
ENSMUSP00000106451
resolver
ensp
ENSMUSP00000297423
resolver
enst
ENSMUST00000050205
resolver
enst
ENSMUST00000071881
resolver
enst
ENSMUST00000110826
resolver
enst
ENSMUST00000110827
resolver
genesymbol
Nudt1
resolver
genesymbol_syn
Mth1
resolver
uniprot
P97795
resolver
uniprot
Q542J4
resolver
uniprot
Q8VDG0
resolver
uniprot_entry
8ODP_MOUSE
resolver
uniprot_sec
P97795
resolver
uniprot_sec
Q542J4
resolver
uniprot_sec
Q8VDG0
resolver
amino_acid_sequence
MSTSRLYTLVLVLQPQRVLLGMKKRGFGAGRWNGFGGKVQEGETIEDGAKRELLEESGLSVDTLHKVGHISFEFVGSPELMDVHIFSADHVHGTPTESEEMRPQWFQLDQIPFADLWPDDSYWFPLLLQKKKFCGHFKFQDQDTILSYSLREVDSF
uniprot
proteins
ec_number
3.6.1.-
uniprot
proteins
ec_number
3.6.1.56
uniprot
proteins
function
FUNCTION: Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool (PubMed:11572992, PubMed:29281266, PubMed:30304478, PubMed:7592783). Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP (By similarity). Also has a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP (PubMed:11572992, PubMed:29281266, PubMed:30304478, PubMed:7592783). Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A (PubMed:11572992, PubMed:29281266, PubMed:30304478, PubMed:7592783). Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA (PubMed:30304478, PubMed:32144205). Through this antimutagenic activity protects cells from oxidative stress (PubMed:11572992, PubMed:29281266, PubMed:30304478, PubMed:32144205, PubMed:7592783). {ECO:0000250|UniProtKB:P36639, ECO:0000269|PubMed:11572992, ECO:0000269|PubMed:29281266, ECO:0000269|PubMed:30304478, ECO:0000269|PubMed:32144205, ECO:0000269|PubMed:7592783}.
uniprot
proteins
mass_dalton
17908
uniprot
proteins
protein_family
Nudix hydrolase family
uniprot
proteins
pubmed
11572992
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29281266
uniprot
proteins
pubmed
30304478
uniprot
proteins
pubmed
32144205
uniprot
proteins
pubmed
7592783
uniprot
proteins
pubmed
9013634
uniprot
proteins
sequence_length
156
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P53369}. Nucleus {ECO:0000250|UniProtKB:P53369}. Nucleus membrane {ECO:0000250|UniProtKB:P53369}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:P53369}.
uniprot
proteins