Mettl18
entrez
69962
canonical
uniprot
Q9CZ09
canonical
ensembl
ENSMUSG00000041396
resolver
ensp
ENSMUSP00000048636
resolver
ensp
ENSMUSP00000107116
resolver
enst
ENSMUST00000045694
resolver
enst
ENSMUST00000111490
resolver
genesymbol
Mettl18
resolver
uniprot
Q810I8
resolver
uniprot_entry
MET18_MOUSE
resolver
uniprot_sec
Q810I8
resolver
amino_acid_sequence
MAFQFNFSIEEDLENKLTSLDDGTCVLESQKGKQDKRQSTERPGLPRDHSWKCSSLGNAASSEDTGSPPPIADRSDDPEACKHQPSWKPAKEHVMPKDVNHVLENTVLEMLPGPQHANTAVVKTVSLKEKFPGENIVSKSFSSHSDLIPGVYEGGLKIWECTFDLLTYFTKAKVKFAGQKVLDLGCGSGLLGITASKGGAREVHFQDYNGLVIDEVTLPNVVANVPLQDDSNGKNEPDGKRQRKSEVGREICKCRLFSGEWAEFCKLVLREKLFVKYDLILTSETIYNPDYYSTLHETFLRLLSRSGRVLLASKAHYFGVGGGVHLFQKFVEEKGVFETRTLEVIDEGLKRFLMEMTFKHPS
uniprot
proteins
ec_number
2.1.1.85
uniprot
proteins
function
FUNCTION: Protein-L-histidine N-tele-methyltransferase that specifically monomethylates RPL3, thereby regulating translation elongation. Histidine methylation of RPL3 regulates translation elongation by slowing ribosome traversal on tyrosine codons: slower elongation provides enough time for proper folding of synthesized proteins and prevents cellular aggregation of tyrosine-rich proteins. {ECO:0000250|UniProtKB:O95568}.
uniprot
proteins
mass_dalton
40448
uniprot
proteins
post_translational_modification
PTM: Monomethylated at His-144 through automethylation. Automethylation at His-144 positively regulates the methyltransferase activity toward RPL3. Probably methylated on other residues. {ECO:0000250|UniProtKB:O95568}.
uniprot
proteins
protein_family
METTL18 family
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
362
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O95568}. Nucleus {ECO:0000250|UniProtKB:O95568}. Nucleus, nucleolus {ECO:0000250|UniProtKB:O95568}.
uniprot
proteins