Oxct1
entrez
690163
canonical
uniprot
B2GV06
canonical
ensembl
ENSRNOG00000043094
resolver
ensembl
ENSRNOG00055006328
resolver
ensembl
ENSRNOG00060014219
resolver
ensembl
ENSRNOG00065021604
resolver
ensp
ENSRNOP00000090363
resolver
ensp
ENSRNOP00055007980
resolver
ensp
ENSRNOP00060019455
resolver
ensp
ENSRNOP00065029591
resolver
enst
ENSRNOT00000107045
resolver
enst
ENSRNOT00055010297
resolver
enst
ENSRNOT00060024375
resolver
enst
ENSRNOT00065036753
resolver
genesymbol
Oxct1
resolver
genesymbol_syn
Oxct
resolver
genesymbol_syn
Scot
resolver
uniprot_entry
SCOT1_RAT
resolver
amino_acid_sequence
MAALKLLSSGLRLCASARNSRGALHKGCACYFSVSTRHHTKFYTDPVEAVKDIPNGATLLVGGFGLCGIPENLIGALLKTGVKDLTAVSNNAGVDNFGLGLLLRSKQIKRMISSYVGENAEFERQFLSGELEVELTPQGTLAERIRAGGAGVPAFYTSTGYGTLVQEGGSPIKYNKDGSVAIASKPREVREFRGQHFILEEAITGDFALVKAWKADRAGNVIFRKSARNFNLPMCKAAGTTVVEVEEIVDIGSFAPEDIHIPKIYVHRLIKGEKYEKRIERLSLRKEGEGKAKSGKPGEDVRERIIKRAALEFEDGMYANLGIGIPLLASNFISPNMTVHLQSENGVLGLGPYPLKDEADADLINAGKETVTVLPGASFFSSDESFAMIRGGHVNLTMLGAMQVSKYGDLANWMIPGKMVKGMGGAMDLVSSSKTKVVVTMEHSAKGNAHKIMEKCTLPLTGKQCVNRIITEKGVFDVDKKNGLTLIELWEGLTVDDIRKSTGCDFAVSPNLMPMQQIST
uniprot
proteins
ec_number
2.8.3.5
uniprot
proteins
function
FUNCTION: Key enzyme for ketone body catabolism. Catalyzes the first, rate-limiting step of ketone body utilization in extrahepatic tissues, by transferring coenzyme A (CoA) from a donor thiolester species (succinyl-CoA) to an acceptor carboxylate (acetoacetate), and produces acetoacetyl-CoA. Acetoacetyl-CoA is further metabolized by acetoacetyl-CoA thiolase into two acetyl-CoA molecules which enter the citric acid cycle for energy production (By similarity). Forms a dimeric enzyme where both of the subunits are able to form enzyme-CoA thiolester intermediates, but only one subunit is competent to transfer the CoA moiety to the acceptor carboxylate (3-oxo acid) and produce a new acyl-CoA. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity). {ECO:0000250|UniProtKB:P55809, ECO:0000250|UniProtKB:Q29551}.
uniprot
proteins
mass_dalton
56204
uniprot
proteins
pathway_participation
PATHWAY: Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1. {ECO:0000250|UniProtKB:P55809}.
uniprot
proteins
protein_family
3-oxoacid CoA-transferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19343716
uniprot
proteins
sequence_length
520
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:19343716}.
uniprot
proteins