Ffar1
entrez
266607
canonical
uniprot
Q8K3T4
canonical
ensembl
ENSRNOG00000024009
resolver
ensp
ENSRNOP00000028533
resolver
genesymbol
Ffar1
resolver
genesymbol_syn
Gpr40
resolver
uniprot_entry
FFAR1_RAT
resolver
amino_acid_sequence
MDLPPQLSFALYVSAFALGFPLNLLAIRGAVSHAKLRLTPSLVYTLHLACSDLLLAITLPLKAVEALASGVWPLPLPFCPVFALAHFAPLYAGGGFLAALSAGRYLGAAFPFGYQAIRRPCYSWGVCVAIWALVLCHLGLALGLEAPRGWVDNTTSSLGINIPVNGSPVCLEAWDPDSARPARLSFSILLFFLPLVITAFCYVGCLRALVHSGLSHKRKLRAAWVAGGALLTLLLCLGPYNASNVASFINPDLEGSWRKLGLITGAWSVVLNPLVTGYLGTGPGQGTICVTRTPRGTIQK
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation. Ligand binding leads to a conformation change that triggers signaling via G proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation. {ECO:0000250|UniProtKB:O14842, ECO:0000250|UniProtKB:Q76JU9}.
uniprot
proteins
mass_dalton
31836
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12496284
uniprot
proteins
pubmed
12629551
uniprot
proteins
sequence_length
300
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O14842}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O14842}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..31; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:O14842, ECO:0000255"; TRANSMEM 42..64; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:O14842, ECO:0000255"; TRANSMEM 80..101; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:O14842, ECO:0000255"; TRANSMEM 122..142; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:O14842, ECO:0000255"; TRANSMEM 179..200; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:O14842, ECO:0000255"; TRANSMEM 224..248; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:O14842, ECO:0000255"; TRANSMEM 257..279; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:O14842, ECO:0000255
uniprot
proteins