DERL3
entrez
91319
canonical
uniprot
Q96Q80
canonical
ensembl
ENSG00000099958
resolver
ensembl
ENSG00000274437
resolver
ensp
ENSP00000315303
resolver
ensp
ENSP00000384744
resolver
ensp
ENSP00000419399
resolver
ensp
ENSP00000548017
resolver
ensp
ENSP00000662946
resolver
ensp
ENSP00000688091
resolver
ensp
ENSP00000736285
resolver
ensp
ENSP00000797056
resolver
genesymbol
DERL3
resolver
genesymbol_syn
C22orf14
resolver
genesymbol_syn
DER3
resolver
genesymbol_syn
LLN2
resolver
hgnc
HGNC:14236
resolver
uniprot
F2Z3B6
resolver
uniprot
Q6ICJ6
resolver
uniprot
Q6PEX0
resolver
uniprot
Q6ZUB5
resolver
uniprot_entry
DERL3_HUMAN
resolver
uniprot_sec
F2Z3B6
resolver
uniprot_sec
Q6ICJ6
resolver
uniprot_sec
Q6PEX0
resolver
uniprot_sec
Q6ZUB5
resolver
amino_acid_sequence
MAWQGLAAEFLQVPAVTRAYTAACVLTTAAVQLELLSPFQLYFNPHLVFRKFQVWRLVTNFLFFGPLGFSFFFNMLFVFRYCRMLEEGSFRGRTADFVFMFLFGGVLMTLLGLLGSLFFLGQALMAMLVYVWSRRSPRVRVNFFGLLTFQAPFLPWALMGFSLLLGNSILVDLLGIAVGHIYYFLEDVFPNQPGGKRLLQTPGFLKLLLDAPAEDPNYLPLPEEQPGPHLPPPQQ
uniprot
proteins
function
FUNCTION: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded glycoproteins (PubMed:16449189, PubMed:22607976). May be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908). {ECO:0000269|PubMed:16449189, ECO:0000269|PubMed:22607976, ECO:0000269|PubMed:26565908}.
uniprot
proteins
mass_dalton
26679
uniprot
proteins
protein_family
Derlin family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15215855
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16449189
uniprot
proteins
pubmed
22016385
uniprot
proteins
pubmed
22607976
uniprot
proteins
pubmed
26565908
uniprot
proteins
sequence_length
235
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16449189}; Multi-pass membrane protein {ECO:0000269|PubMed:16449189}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..43; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 59..79; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 99..119; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 158..178; /note="Helical; Name=4"; /evidence="ECO:0000255
uniprot
proteins