Lilrb4a
entrez
14728
canonical
uniprot
Q64281
canonical
ensembl
ENSMUSG00000062593
resolver
ensembl
ENSMUSG00000112148
resolver
ensp
ENSMUSP00000077833
resolver
ensp
ENSMUSP00000353250
resolver
genesymbol
Lilrb4a
resolver
genesymbol_syn
Gp49b
resolver
uniprot
Q64312
resolver
uniprot_entry
LRB4A_MOUSE
resolver
uniprot_sec
Q64312
resolver
amino_acid_sequence
MIAMLTVLLYLGLILEPRTAVQAGHLPKPIIWAEPGSVIAAYTSVITWCQGSWEAQYYHLYKEKSVNPWDTQVPLETRNKAKFNIPSMTTSYAGIYKCYYESAAGFSEHSDAMELVMTGAYENPSLSVYPSSNVTSGVSISFSCSSSIVFGRFILIQEGKHGLSWTLDSQHQANQPSYATFVLDAVTPNHNGTFRCYGYFRNEPQVWSKPSNSLDLMISETKDQSSTPTEDGLETYQKILIGVLVSFLLLFFLLLFLILIGYQYGHKKKANASVKNTQSENNAELNSWNPQNEDPQGIVYAQVKPSRLQKDTACKETQDVTYAQLCIRTQEQNNS
uniprot
proteins
function
FUNCTION: Inhibitory receptor involved in the down-regulation of the immune response (PubMed:10026201, PubMed:24935931). Receptor for FN1 (PubMed:34089617). Receptor for integrin ITGAV/ITGB3 (PubMed:11323698). Inhibits IgE-mediated mast cell activation, at least in part through interaction with ITGAV/ITGB3 (PubMed:10026201, PubMed:11323698, PubMed:11457897, PubMed:8855262). Also inhibits KITLG/SCF-mediated mast cell activation (PubMed:12884301). Through interaction with ITGAV/ITGB3, inhibits antibody production by memory and marginal zone B cells, probably by suppressing their differentiation into plasma cells (PubMed:24935931). Inhibits IFNG production by CD8 T cells, CD4 T cells and natural killer cells (PubMed:12682239). Inhibits antigen presentation by dendritic cells to T cells, preventing T cell activation (PubMed:18792399). Inhibits lipopolysaccharide-mediated neutrophil-dependent vascular injury (PubMed:14557414). Suppresses the allergic inflammatory response by inhibiting infiltration of neutrophils and eosinophils and preventing mast cell degranulation (PubMed:17761953). Inhibits lysis by natural killer cells (PubMed:8977169). {ECO:0000269|PubMed:10026201, ECO:0000269|PubMed:11323698, ECO:0000269|PubMed:11457897, ECO:0000269|PubMed:12682239, ECO:0000269|PubMed:12884301, ECO:0000269|PubMed:14557414, ECO:0000269|PubMed:17761953, ECO:0000269|PubMed:18792399, ECO:0000269|PubMed:24935931, ECO:0000269|PubMed:34089617, ECO:0000269|PubMed:8855262, ECO:0000269|PubMed:8977169}.
uniprot
proteins
mass_dalton
37544
uniprot
proteins
mutagenesis
MUTAGEN 300; /note="Y->F: Partially suppresses inhibition of mast cell activation. Abolishes inhibition of mast cell activation; when associated with F-322."; /evidence="ECO:0000269|PubMed:10026201"; MUTAGEN 322; /note="Y->F: Partially suppresses inhibition of mast cell activation. Abolishes inhibition of mast cell activation; when associated with F-300."; /evidence="ECO:0000269|PubMed:10026201
uniprot
proteins
post_translational_modification
PTM: Tyrosine phosphorylated. {ECO:0000269|PubMed:10026201, ECO:0000269|PubMed:9973385}.
uniprot
proteins
pubmed
10026201
uniprot
proteins
pubmed
10982834
uniprot
proteins
pubmed
11323698
uniprot
proteins
pubmed
11457897
uniprot
proteins
pubmed
12682239
uniprot
proteins
pubmed
12884301
uniprot
proteins
pubmed
14557414
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17761953
uniprot
proteins
pubmed
18792399
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
24935931
uniprot
proteins
pubmed
34089617
uniprot
proteins
pubmed
8132564
uniprot
proteins
pubmed
8855262
uniprot
proteins
pubmed
8977169
uniprot
proteins
pubmed
8977170
uniprot
proteins
pubmed
9338594
uniprot
proteins
pubmed
9422771
uniprot
proteins
pubmed
9973385
uniprot
proteins
sequence_length
335
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10982834, ECO:0000269|PubMed:11323698, ECO:0000269|PubMed:8855262, ECO:0000269|PubMed:8977169}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 239..260; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins