Rnf125
entrez
67664
canonical
uniprot
Q9D9R0
canonical
ensembl
ENSMUSG00000033107
resolver
ensp
ENSMUSP00000058251
resolver
ensp
ENSMUSP00000157304
resolver
genesymbol
Rnf125
resolver
uniprot
Q0VG32
resolver
uniprot
Q52KL4
resolver
uniprot
Q8C7F2
resolver
uniprot_entry
RN125_MOUSE
resolver
uniprot_sec
Q0VG32
resolver
uniprot_sec
Q52KL4
resolver
uniprot_sec
Q8C7F2
resolver
amino_acid_sequence
MGSLLSSDSSKSAPASATPRTLERSGDSELPITSFDCSVCLEVLHQPVRTRCGHVFCRSCIATSIKNNNKWTCPYCRAYLPSEGVPATDIAKRMKSEYQNCAECGTLVCLSDMRAHIRTCEKYIDKYGPLLELGDTTARCVCPFCQRELDEDCLLDHCIIHHRSERRPVFCPLCHSRPDESPSTFNGSLIRHLQVSHTLFYDDFIDFDIIEEAIIRRVLDRSLLEYVNQSNTT
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as RIGI, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53. Acts as a negative regulator of type I interferon production by mediating ubiquitination of RIGI at 'Lys-181', leading to RIGI degradation. Mediates ubiquitination and subsequent degradation of p53/TP53. Mediates ubiquitination and subsequent degradation of JAK1. Acts as a positive regulator of T-cell activation. {ECO:0000250|UniProtKB:Q96EQ8}.
uniprot
proteins
mass_dalton
26362
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q96EQ8}.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated, leading to its subsequent proteasomal degradation. {ECO:0000250|UniProtKB:Q96EQ8}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
233
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q96EQ8}; Lipid-anchor {ECO:0000250|UniProtKB:Q96EQ8}. Note=Shows a reticular staining pattern within the cell and is probably expressed at other intracellular membranes in addition to the Golgi membrane. Not detected at the plasma membrane. {ECO:0000250|UniProtKB:Q96EQ8}.
uniprot
proteins