Htra3
entrez
360959
canonical
uniprot
D3ZA76
canonical
ensembl
ENSRNOG00000008182
resolver
ensembl
ENSRNOG00055016546
resolver
ensembl
ENSRNOG00060021239
resolver
ensembl
ENSRNOG00065031168
resolver
ensp
ENSRNOP00000010852
resolver
ensp
ENSRNOP00000093047
resolver
genesymbol
Htra3
resolver
genesymbol_syn
Prsp
resolver
uniprot
D3ZLW3
resolver
uniprot_entry
HTRA3_RAT
resolver
uniprot_sec
D3ZLW3
resolver
amino_acid_sequence
MQARALLPATLATLATLAVSVLAREPPAAPCPARCDVSRCPSPRCPGGYVPDLCNCCLVCAASEGEPCGRPLDSPCGDSLECVRGVCRCRWTHTVCGTDGHTYADVCALQAASRRALQISGTPVRQLQKGACPSGLHQLTSPRYKFNFIADVVEKIAPAVVHIELFLRHPLFGRNVPLSSGSGFIMSEAGLIVTNAHVVSSSNTASGRQQLKVQLQNGDAYEATIQDIDKKSDIATILIHPNKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQRDGKELGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVAAGISFAIPSDRITRFLSEFQDKHVKDWKKRFIGIRMRTITPSLVEELKTANPDFPAVSSGIYVQEVVPNSPSQRGGIQDGDIIVKVNGRPLVDSSELQEAVLNESSLLLEVRRGNDDLLFSIMPEVVM
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Inhibits signaling mediated by TGF-beta family proteins possibly indirectly by degradation of these ECM proteoglycans (By similarity). May act as a tumor suppressor. Negatively regulates, in vitro, trophoblast invasion during placental development and may be involved in the development of the placenta in vivo. May also have a role in ovarian development, granulosa cell differentiation and luteinization (By similarity). {ECO:0000250|UniProtKB:P83110, ECO:0000250|UniProtKB:Q9D236}.
uniprot
proteins
mass_dalton
49257
uniprot
proteins
protein_family
Peptidase S1C family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
19415717
uniprot
proteins
sequence_length
459
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P83110}. Note=Secretion increased during decidualization of endometrial stromal cells. {ECO:0000250|UniProtKB:P83110}.
uniprot
proteins