ELOVL2
entrez
54898
canonical
uniprot
Q9NXB9
canonical
ensembl
ENSG00000197977
resolver
ensp
ENSP00000346693
resolver
enst
ENST00000354666
resolver
genesymbol
ELOVL2
resolver
genesymbol_syn
ELG3
resolver
genesymbol_syn
SSC2
resolver
hgnc
HGNC:14416
resolver
uniprot
Q6P9E1
resolver
uniprot
Q86W94
resolver
uniprot_entry
ELOV2_HUMAN
resolver
uniprot_sec
Q6P9E1
resolver
uniprot_sec
Q86W94
resolver
amino_acid_sequence
MEHLKAFDDEINAFLDNMFGPRDSRVRGWFMLDSYLPTFFLTVMYLLSIWLGNKYMKNRPALSLRGILTLYNLGITLLSAYMLAELILSTWEGGYNLQCQDLTSAGEADIRVAKVLWWYYFSKSVEFLDTIFFVLRKKTSQITFLHVYHHASMFNIWWCVLNWIPCGQSFFGPTLNSFIHILMYSYYGLSVFPSMHKYLWWKKYLTQAQLVQFVLTITHTMSAVVKPCGFPFGCLIFQSSYMLTLVILFLNFYVQTYRKKPMKKDMQEPPAGKEVKNGFSKAYFTAANGVMNKKAQ
uniprot
proteins
ec_number
2.3.1.199
uniprot
proteins
function
FUNCTION: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA), acting specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. May participate in the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000255|HAMAP-Rule:MF_03202, ECO:0000269|PubMed:11734209, ECO:0000269|PubMed:12371743, ECO:0000269|PubMed:19575253, ECO:0000269|PubMed:20937905}.
uniprot
proteins
mass_dalton
34585
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; polyunsaturated fatty acid biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03202, ECO:0000269|PubMed:11734209, ECO:0000269|PubMed:12371743, ECO:0000269|PubMed:19575253, ECO:0000269|PubMed:20937905}.
uniprot
proteins
protein_family
ELO family
uniprot
proteins
protein_family
ELOVL2 subfamily
uniprot
proteins
pubmed
11734209
uniprot
proteins
pubmed
12371743
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19575253
uniprot
proteins
pubmed
20937905
uniprot
proteins
pubmed
38422897
uniprot
proteins
sequence_length
296
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03202, ECO:0000269|PubMed:20937905}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03202}.
uniprot
proteins
transmembrane_region
TRANSMEM 29..49; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03202"; TRANSMEM 67..87; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03202"; TRANSMEM 115..135; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03202"; TRANSMEM 153..173; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03202"; TRANSMEM 175..195; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03202"; TRANSMEM 208..225; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03202"; TRANSMEM 230..250; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03202
uniprot
proteins