Plk2
entrez
83722
canonical
uniprot
Q9R012
canonical
ensembl
ENSRNOG00000011951
resolver
ensembl
ENSRNOG00055011728
resolver
ensembl
ENSRNOG00060003936
resolver
ensembl
ENSRNOG00065019840
resolver
ensp
ENSRNOP00000016768
resolver
ensp
ENSRNOP00055016070
resolver
ensp
ENSRNOP00060004930
resolver
ensp
ENSRNOP00065026746
resolver
enst
ENSRNOT00000016768
resolver
enst
ENSRNOT00055019942
resolver
enst
ENSRNOT00060006581
resolver
enst
ENSRNOT00065033443
resolver
genesymbol
Plk2
resolver
genesymbol_syn
Snk
resolver
uniprot_entry
PLK2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation of Thr-236. Once activated, activity is stimulated by binding target proteins (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MELLRTITYQPAAGTKMCEQALGKACGGDSKKKRPQQPSEDGQSQAQVTPAAPHHHHHHSHSGPEISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYNDTHNKVSKEDEDIYKLRHDLKKTSITQQPSKHRTDEELQPPPTTFAKSGTSAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICNQNEEYLLTYINEDRISTTFRLTTLLMSGCSLELKHRMEYALNMLLQRCN
uniprot
proteins
ec_number
2.7.11.21
uniprot
proteins
function
FUNCTION: Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CPAP, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CPAP and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress. {ECO:0000269|PubMed:10523297, ECO:0000269|PubMed:18498738, ECO:0000269|PubMed:18723513, ECO:0000269|PubMed:20802490, ECO:0000269|PubMed:21382555}.
uniprot
proteins
mass_dalton
77920
uniprot
proteins
mutagenesis
MUTAGEN 108; /note="K->M: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:20802490, ECO:0000269|PubMed:21382555"; MUTAGEN 202; /note="D->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:18723513"; MUTAGEN 236; /note="T->E: Mimicks phosphorylation state, leading to increased activity."; /evidence="ECO:0000269|PubMed:20802490, ECO:0000269|PubMed:21382555"; MUTAGEN 504; /note="W->A: Abolishes interaction with SIPA1L1."; /evidence="ECO:0000269|PubMed:18498738, ECO:0000269|PubMed:20802490"; MUTAGEN 504; /note="W->F: Does not affect interaction with NSF and ability to dissociate NSF from GRIA2."; /evidence="ECO:0000269|PubMed:18498738, ECO:0000269|PubMed:20802490
uniprot
proteins
post_translational_modification
PTM: Catalytic activity is enhanced by phosphorylation of Thr-236. {ECO:0000269|PubMed:20802490}.
uniprot
proteins
protein_family
CDC5/Polo subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Ser/Thr protein kinase family
uniprot
proteins
pubmed
10523297
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18498738
uniprot
proteins
pubmed
18723513
uniprot
proteins
pubmed
20802490
uniprot
proteins
pubmed
21382555
uniprot
proteins
sequence_length
682
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250}. Cell projection, dendrite {ECO:0000269|PubMed:10523297}. Note=Localizes to centrosomes during early G1 phase where it only associates to the mother centriole and then distributes equally to both mother and daughter centrioles at the onset of S phase. {ECO:0000250}.
uniprot
proteins