Il5ra
entrez
16192
canonical
uniprot
P21183
canonical
ensembl
ENSMUSG00000005364
resolver
ensp
ENSMUSP00000129781
resolver
ensp
ENSMUSP00000144718
resolver
enst
ENSMUST00000167925
resolver
enst
ENSMUST00000204659
resolver
genesymbol
Il5ra
resolver
genesymbol_syn
Il5r
resolver
uniprot
Q05A81
resolver
uniprot_entry
IL5RA_MOUSE
resolver
uniprot_entry
Q05A81_MOUSE
resolver
amino_acid_sequence
MVPVLLILVGALATLQADLLNHKKFLLLPPVNFTIKATGLAQVLLHWDPNPDQEQRHVDLEYHVKINAPQEDEYDTRKTESKCVTPLHEGFAASVRTILKSSHTTLASSWVSAELKAPPGSPGTSVTNLTCTTHTVVSSHTHLRPYQVSLRCTWLVGKDAPEDTQYFLYYRFGVLTEKCQEYSRDALNRNTACWFPRTFINSKGFEQLAVHINGSSKRAAIKPFDQLFSPLAIDQVNPPRNVTVEIESNSLYIQWEKPLSAFPDHCFNYELKIYNTKNGHIQKEKLIANKFISKIDDVSTYSIQVRAAVSSPCRMPGRWGEWSQPIYVGKERKSLVEWHLIVLPTAACFVLLIFSLICRVCHLWTRLFPPVPAPKSNIKDLPVVTEYEKPSNETKIEVVHCVEEVGFEVMGNSTF
uniprot
proteins
function
FUNCTION: Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:1873482). Acts by forming a heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5. In unstimulated conditions, interacts constitutively with JAK2. Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway. {ECO:0000250|UniProtKB:Q01344, ECO:0000269|PubMed:1873482}.
uniprot
proteins
mass_dalton
46989
uniprot
proteins
pubmed
1873482
uniprot
proteins
pubmed
2265612
uniprot
proteins
sequence_length
415
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 340..361; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins