LARGE2
entrez
120071
canonical
uniprot
Q8N3Y3
canonical
ensembl
ENSG00000165905
resolver
ensp
ENSP00000324570
resolver
ensp
ENSP00000385235
resolver
ensp
ENSP00000431932
resolver
ensp
ENSP00000432869
resolver
ensp
ENSP00000531648
resolver
ensp
ENSP00000531652
resolver
ensp
ENSP00000596427
resolver
ensp
ENSP00000596428
resolver
ensp
ENSP00000596438
resolver
ensp
ENSP00000754520
resolver
enst
ENST00000325468
resolver
enst
ENST00000401752
resolver
enst
ENST00000529052
resolver
enst
ENST00000531526
resolver
enst
ENST00000861589
resolver
enst
ENST00000926368
resolver
genesymbol
LARGE2
resolver
genesymbol_syn
GYLTL1B
resolver
hgnc
HGNC:16522
resolver
uniprot
A6NN75
resolver
uniprot
B3KP69
resolver
uniprot
E9PIZ2
resolver
uniprot
Q8N8Y6
resolver
uniprot
Q8NAK3
resolver
uniprot
Q8WY62
resolver
uniprot_entry
B3KP69_HUMAN
resolver
uniprot_entry
E9PIZ2_HUMAN
resolver
uniprot_entry
LARG2_HUMAN
resolver
uniprot_sec
A6NN75
resolver
uniprot_sec
Q8N8Y6
resolver
uniprot_sec
Q8NAK3
resolver
uniprot_sec
Q8WY62
resolver
amino_acid_sequence
MLPRGRPRALGAAALLLLLLLLGFLLFGGDLGCERREPGGRAGAPGCFPGPLMPRVPPDGRLRRAAALDGDPGAGPGDHNRSDCGPQPPPPPKCELLHVAIVCAGHNSSRDVITLVKSMLFYRKNPLHLHLVTDAVARNILETLFHTWMVPAVRVSFYHADQLKPQVSWIPNKHYSGLYGLMKLVLPSALPAELARVIVLDTDVTFASDISELWALFAHFSDTQAIGLVENQSDWYLGNLWKNHRPWPALGRGFNTGVILLRLDRLRQAGWEQMWRLTARRELLSLPATSLADQDIFNAVIKEHPGLVQRLPCVWNVQLSDHTLAERCYSEASDLKVIHWNSPKKLRVKNKHVEFFRNFYLTFLEYDGNLLRRELFVCPSQPPPGAEQLQQALAQLDEEDPCFEFRQQQLTVHRVHVTFLPHEPPPPRPHDVTLVAQLSMDRLQMLEALCRHWPGPMSLALYLTDAEAQQFLHFVEASPVLAARQDVAYHVVYREGPLYPVNQLRNVALAQALTPYVFLSDIDFLPAYSLYDYLRASIEQLGLGSRRKAALVVPAFETLRYRFSFPHSKVELLALLDAGTLYTFRYHEWPRGHAPTDYARWREAQAPYRVQWAANYEPYVVVPRDCPRYDPRFVGFGWNKVAHIVELDAQEYELLVLPEAFTIHLPHAPSLDISRFRSSPTYRDCLQALKDEFHQDLSRHHGAAALKYLPALQQPQSPARG
uniprot
proteins
ec_number
2.4.-.-
uniprot
proteins
ec_number
2.4.1.-
uniprot
proteins
ec_number
2.4.2.-
uniprot
proteins
function
FUNCTION: Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity and in a phosphorylated-O-mannosyl trisaccharide dependent manner (PubMed:15661757, PubMed:15752776, PubMed:25138275). Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide (By similarity). Supports the maturation of DAG1 more effectively than LARGE1 (PubMed:15752776). In addition, can modify both heparan sulfate (HS)- and chondroitin/dermatan sulfate (CS/DS)-proteoglycans (PGs), namely GPC4, with a glycosaminoglycan (GAG)-like polysaccharide composed of xylose and glucuronic acid to confer laminin binding (By similarity). {ECO:0000250|UniProtKB:Q5XPT3, ECO:0000269|PubMed:15661757, ECO:0000269|PubMed:15752776, ECO:0000269|PubMed:25138275}.
uniprot
proteins
mass_dalton
81787
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:15661757, ECO:0000269|PubMed:15752776, ECO:0000269|PubMed:25138275}.
uniprot
proteins
protein_family
Glycosyltransferase 49 family; Glycosyltransferase 8 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
15661757
uniprot
proteins
pubmed
15752776
uniprot
proteins
pubmed
15958417
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
19587235
uniprot
proteins
pubmed
25138275
uniprot
proteins
sequence_length
721
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:15661757}; Single-pass type II membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins