Phlpp2
entrez
244650
canonical
uniprot
Q8BXA7
canonical
ensembl
ENSMUSG00000031732
resolver
ensp
ENSMUSP00000034175
resolver
ensp
ENSMUSP00000136166
resolver
enst
ENSMUST00000034175
resolver
enst
ENSMUST00000179721
resolver
genesymbol
Phlpp2
resolver
genesymbol_syn
Phlppl
resolver
uniprot
J3QM82
resolver
uniprot
Q148U6
resolver
uniprot
Q8BX96
resolver
uniprot_entry
J3QM82_MOUSE
resolver
uniprot_entry
PHLP2_MOUSE
resolver
uniprot_sec
Q148U6
resolver
uniprot_sec
Q8BX96
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by AKT1, AKT2 and AKT3. Activated by oleic acid and arachidonic acid. {ECO:0000250|UniProtKB:Q6ZVD8}.
uniprot
proteins
amino_acid_sequence
MKHNGSRTCLNRRSRFGSRERDWLREDVKRGCVYLYGADTTTATTTTSSSSSSSSSSDLHLVLCTVETPASEICAGEGRESLYLQLHGDLVRRLEPSERPLQIVYDYLSRLGFEDPVRIQEEATNPDLSCMIRFYGEKPCQMDHLDRILLSGIYNVRKGKTQLHKWAERLVVLCGTCLIVSSVKDCQTGKMHILPLVGGKIEEVKRRQHSLAFSSAGAQAQTYHVSFETLAEYQRWQRQASKVVSQRMSTVDLSCYSLEEVPEHLFYSQDITYLNLRHNFMQLERPGGLDTLHKFSQLKGLNLSHNKLGLFPVLLCEISTLTELSLSCNGFHDLPSQIGKLLNLQTLSLDGNGLTALPDELGNLRQLTSLGISFNDFRHIPEVLEKLTMLDKVAMAGNRLEVLNLGALTRMSQVKHVDLRMNHLKTVITENMEGNKHITHMDLRDNQLTDLDLSSLCSLEQLHCERNQLRELTLSGFSLRTLYASWNRLTAVNVYPVPSLLTSLELSQNLLECVPDWACEAKKLEILDISHNLLTEVPMRILSSLSLRKLMVGHNHIHVLPALVEHIPLEVLDIQHNTLSRLPDTLFSKALNLRYLNASANSLESLPSACAGEESLSVLQLLYLTSNLLTDQCIPVLVGHPHLRVLHLANNQLQTFPASKLNKLEQLEELNLSGNKLTAIPTTIANCKRLHTLVAHANNISIFPEILQLPQIQFVDLSCNDLTEILIPEALPATLQDLDLTGNTNLVLEHKTLDMFSHITALKIDQKPLPATDSAVTSTFWSHGLAEMAGQRNKLCVSALAMDNFAEGVGAVYGMFDGDRNEELPRLLQCTMADVLLEEVQHSTNDTVFMTNTFLVSHRKLGMAGQKLGSSALLCYIRPDTADPTSSFSLTVANVGMCQAVLCRGGKPVPLSKVFSLEHDPEEAQRVKDQKAIITEDNKVNGVTCCTRLLGCTYLYPWILPKPHIASTPLTIQDELLILGNKALWEHLSYLEAVNAVRHVQDPLAAAKKLCTLAQSYGCQDNVGAMVVYLNIGEEGCTCEMNGLTLPGPVGFASTAALKDTPKPTTPSSSSGIASEFSSEMSTSEVSSEVGSTASDEHNTVGLEASLLPRPERRCSLHPASSAGVFQRQPSCATFSSNQSDNGLDSDDDQPVEGVITNGSRVEVEVDIHCCRGREPESSPPLPKNSSNACSEERARGAGFGIRRQNSVNSGILLPANRDKMELQKSPSTSCLYGKKLSNGSIVPLEDSLNLIEVATEAPKRKTGYFAAPTQLEPEDQFVVPRDLEEEVKEQMKQHQEGRPEPEPRGEERTEPLEEFDTAL
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Protein phosphatase involved in regulation of Akt and PKC signaling. Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT1, 'Ser-660' of PRKCB isoform beta-II and 'Ser-657' of PRKCA. Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes. Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and decreases cell proliferation. Also controls the phosphorylation of AKT3. Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis. Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation. Inhibits cancer cell proliferation and may act as a tumor suppressor. Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation. Dephosphorylates RAF1 inhibiting its kinase activity (By similarity). {ECO:0000250|UniProtKB:Q6ZVD8}.
uniprot
proteins
mass_dalton
145947
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20089132
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1320
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6ZVD8}. Membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6ZVD8}. Nucleus {ECO:0000250|UniProtKB:Q6ZVD8}.
uniprot
proteins