Ddx50
entrez
94213
canonical
uniprot
Q99MJ9
canonical
ensembl
ENSMUSG00000020076
resolver
ensp
ENSMUSP00000020270
resolver
ensp
ENSMUSP00000224804
resolver
enst
ENSMUST00000020270
resolver
genesymbol
Ddx50
resolver
uniprot
Q8BRU5
resolver
uniprot_entry
DDX50_MOUSE
resolver
uniprot_entry
Q8BRU5_MOUSE
resolver
amino_acid_sequence
MPGKLLWGDIMELEAPLEESESQRKERQKSDRRKSRHHSESEERTETRENGVTDDLDAPKPKKAKMREKLNGDTKEGLRFSDEFSPSHKSRRKDLPNGDVDEYEKRSKRVSSSENSHKSSDKAEETLTREQKEGAFSNFSISEETIKLLKGRGVTYLFPIQVKTFGPVYEGKDLIAQARTGTGKTFSFAIPLIERLQRNQETIKKSRSPKVLVLAPTRELANQVAKDFKDITRKLSVACFYGGTSYQSQINQIRNGIDILVGTPGRIKDHLQSGRLDLSKLRHVVLDEVDQMLDLGFAEQVEDIIHESYKTDSEDNPQTLLFSATCPQWVYKVAKKYMKSRYEQVDLVGKMTQKAATTVEHLAIQCHWSQRPAVIGDVLQVYSGSEGRAIIFCETKKNVTEMAMNPHIKQNAQCLHGDIAQSQREITLKGFREGSFKVLVATNVAARGLDIPEVDLVIQSSPPQDVESYIHRSGRTGRAGRTGICVCFYQPRERGQLRYVEQKAGITFKRVGVPSTMDLVKSKSMDAIRSLASVSYAAVDFFRPSAQRLIEEKGAVDALAAALAHISGASSFEPRSLITSDKGFVTMTLESPEEIQDVSCAWKELNRKLSSNAVSHVTRMCLLKGNMGVCFDVPTSESERLQAEWHDSDWILSVPAKLPEIEEYYDGNTSSNPRQRSGWSGGRSGRSGRSGGRSGGRSGRQSRQGSRSGSRQDGRRRSGNRNRSRSGGHKRNFD
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: ATP-dependent RNA helicase that may play a role in various aspects of RNA metabolism including pre-mRNA splicing or ribosomal RNA production. Also acts as a viral restriction factor and promotes the activation of the NF-kappa-B and IRF3 signaling pathways following its stimulation with viral RNA or infection with RNA and DNA viruses. For instance, decreases vaccinia virus, herpes simplex virus, Zika virus or dengue virus replication during the early stage of infection. Mechanistically, acts via the adapter TICAM1 and independently of the DDX1-DDX21-DHX36 helicase complex to induce the production of interferon-beta. {ECO:0000250|UniProtKB:Q9BQ39}.
uniprot
proteins
mass_dalton
82175
uniprot
proteins
protein_family
DDX21/DDX50 subfamily
uniprot
proteins
protein_family
DEAD box helicase family
uniprot
proteins
pubmed
11891046
uniprot
proteins
sequence_length
734
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9BQ39}. Cytoplasm {ECO:0000250|UniProtKB:Q9BQ39}. Note=Accumulates in the cytoplasm to activate signaling upstream of IRF3 during viral infection. {ECO:0000250|UniProtKB:Q9BQ39}.
uniprot
proteins