Rest
entrez
83618
canonical
uniprot
O54963
canonical
ensembl
ENSRNOG00000002074
resolver
ensp
ENSRNOP00000002837
resolver
enst
ENSRNOT00000002837
resolver
genesymbol
Rest
resolver
genesymbol_syn
Nrsf
resolver
uniprot
F1M9A3
resolver
uniprot
O54964
resolver
uniprot_entry
F1M9A3_RAT
resolver
uniprot_entry
REST_RAT
resolver
uniprot_sec
O54964
resolver
amino_acid_sequence
MATQVMGQSSGGGSLFNNSGNMGMALPNDMYDLHDLSKAELAAPQLIMLANVALTGEVNGSCCDYLVGEERQMAELMPVGDNHFSDSEGEGLEESAELKGDPSGLDNMELRSLELSVVEPQPVFEASAAPEVYSSNKDPAPEAPVAEDKCKNLKAKPFRCKPCQYEAESEEQFVHHIRVHSAKKFFVEESAEKQAKARESGASPSEEGEFSKGPIRCDRCGYNTNRYDHYTAHLKHHLRAGDNERVYKCIICTYTTVSEYHWRKHLRNHFPRKVYTCSKCNYFSTEKNNYVQHVRTHTGERPYKCELCPYSSSQKTHLTRHMRTHSGEKPFKCDQCNYVASNQHEVTRHARQVHNGPKPLNCPHCDYKTADRSNFKKHVELHVNPRQFNCPVCDYAASKKCNLQYHFKSKHPTCPSKTMDVSKVKLKKTKRREADLHRDAAAAATEQTDTEQAKTKGVDASARRSERPVKGVGKDVPKEKKPCSNASVVQVTTRTRKSAVETKAAEGKHTDGQTGNNAEKSSKAKKSKRKMDAEAHPSVEPVTEGPVTKKKKTESKPKTSGEVPKGSRVEDRKADKQQSASIKKGGKKTALKTKTAKKGSKLAPKWVGHTEPSSEMAQGGESPVPALTQAVVTPSGSTQTELSSPMDIAQTEPAQMDVSQTGPPQVQRPLPVEPAQLEPSPPQEPPQVEPPACVEPPPPVEPPCPMEPAEMEPSPPMEPSQVEPPPHLEPPLPMELPQVELPPVEDCQKELPPVEHAQTKVAQTGPTQVGAVQEEPLFCLRATSSQANQKVISPKDRAKEKLSVLSEMARQEQVLIEVGLVPVRDSQLLKASKSAPDLPAPPSPLPKGHLRREETPKDQEMFSDGEGNKVSPLEKGGTEEAGESRAELAAPMESTSALSSEQSSNAPDGETLHSECQADSTAVCEMEVDTEQKTDRVPLKDSAVEPVSPLNPRVDPEAAAPAVVASPPITLAESQEIDEDEGIHSHDGSDLSDNMSEGSDDSGLHGARPAPQEATSKSGKEGLAVKVTEGEFVCIFCDRSFRKEKDYSKHLNRHLVNVYFLEEAAEEQE
uniprot
proteins
function
FUNCTION: Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells (By similarity). Restricts the expression of neuronal genes by associating with two distinct corepressors, SIN3A and RCOR1, which in turn recruit histone deacetylase to the promoters of REST-regulated genes (By similarity). Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier (PubMed:9454838). Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression (By similarity). Represses the expression of SRRM4 in non-neural cells to prevent the activation of neural-specific splicing events and to prevent production of REST isoform 6 (By similarity). Repressor activity may be inhibited by forming heterodimers with isoform 6, thereby preventing binding to NRSE or binding to corepressors and leading to derepression of target genes (By similarity). Also maintains repression of neuronal genes in neural stem cells, and allows transcription and differentiation into neurons by dissociation from RE1/NRSE sites of target genes (By similarity). Thereby is involved in maintaining the quiescent state of adult hippocampal neural stem cells and preventing premature differentiation into mature neurons (By similarity). Plays a role in the developmental switch in synaptic NMDA receptor composition during postnatal development, by repressing GRIN2B expression and thereby altering NMDA receptor properties from containing primarily GRIN2B to primarily GRIN2A subunits (PubMed:22960932). Acts as a regulator of osteoblast differentiation (By similarity). Key repressor of gene expression in hypoxia; represses genes in hypoxia by direct binding to an RE1/NRSE site on their promoter regions (By similarity). May also function in stress resistance in the brain during aging; possibly by regulating expression of genes involved in cell death and in the stress response (By similarity). Repressor of gene expression in the hippocampus after ischemia by directly binding to RE1/NRSE sites and recruiting SIN3A and RCOR1 to promoters of target genes, thereby promoting changes in chromatin modifications and ischemia-induced cell death (PubMed:12657670, PubMed:22371606). After ischemia, might play a role in repression of miR-132 expression in hippocampal neurons, thereby leading to neuronal cell death (PubMed:25108103). {ECO:0000250|UniProtKB:Q13127, ECO:0000250|UniProtKB:Q8VIG1, ECO:0000269|PubMed:12657670, ECO:0000269|PubMed:22371606, ECO:0000269|PubMed:22960932, ECO:0000269|PubMed:25108103, ECO:0000269|PubMed:9454838}.; FUNCTION: [Isoform 6]: Binds to the 3' region of the neuron-restrictive silencer element (NRSE), with lower affinity than full-length REST isoform 1 (By similarity). Exhibits weaker repressor activity compared to isoform 1 (By similarity). May negatively regulate the repressor activity of isoform 1 by binding to isoform 1, thereby preventing its binding to NRSE and leading to derepression of target genes (By similarity). However, in another study, does not appear to be implicated in repressor activity of a NRSE motif-containing reporter construct nor in inhibitory activity on the isoform 1 transcriptional repressor activity (By similarity). Post-transcriptional inactivation of REST by SRRM4-dependent alternative splicing into isoform 6 is required in mechanosensory hair cells in the inner ear for derepression of neuronal genes and hearing (By similarity). {ECO:0000250|UniProtKB:Q13127, ECO:0000250|UniProtKB:Q8VIG1}.
uniprot
proteins
mass_dalton
117126
uniprot
proteins
post_translational_modification
PTM: O-glycosylated. {ECO:0000250|UniProtKB:Q8VIG1}.; PTM: Phosphorylated; phosphorylation is required for ubiquitination. {ECO:0000250|UniProtKB:Q13127}.; PTM: Ubiquitinated; ubiquitination is mediated by BTRC and leads to proteasomal degradation in G2 phase (By similarity). Ubiquitination increases during neuronal differentiation (By similarity). Deubiquitinated by USP7; leading to its stabilization and promoting the maintenance of neural progenitor cells (By similarity). {ECO:0000250|UniProtKB:Q13127}.
uniprot
proteins
pubmed
10490617
uniprot
proteins
pubmed
12657670
uniprot
proteins
pubmed
22371606
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
22960932
uniprot
proteins
pubmed
25108103
uniprot
proteins
pubmed
9454838
uniprot
proteins
sequence_length
1069
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10490617, ECO:0000269|PubMed:12657670, ECO:0000269|PubMed:22371606, ECO:0000269|PubMed:22960932}. Cytoplasm {ECO:0000250|UniProtKB:Q13127}. Note=Colocalizes with ZFP90 in the nucleus (By similarity). In response to hypoxia, there is a more pronounced increase in levels in the nucleus as compared to the cytoplasm (By similarity). In aging neurons, increased levels in the nucleus as compared to the cytoplasm (By similarity). {ECO:0000250|UniProtKB:Q13127, ECO:0000250|UniProtKB:Q8VIG1}.; SUBCELLULAR LOCATION: [Isoform 6]: Nucleus {ECO:0000250|UniProtKB:Q13127}.
uniprot
proteins