Tafa5
entrez
106014
canonical
uniprot
Q91WE9
canonical
ensembl
ENSMUSG00000054863
resolver
ensp
ENSMUSP00000064808
resolver
ensp
ENSMUSP00000155322
resolver
genesymbol
Tafa5
resolver
genesymbol_syn
Fam19a5
resolver
uniprot
Q8C1V6
resolver
uniprot_entry
TAFA5_MOUSE
resolver
uniprot_sec
Q8C1V6
resolver
amino_acid_sequence
MAPSPRTSSRQDATALPSMSSTFWAFMILASLLIAYCSQLAAGTCEIVTLDRDSSQPRRTIARQTARCACRKGQIAGTTRARPACVDARIIKTKQWCDMLPCLEGEGCDLLINRSGWTCTQPGGRIKTTTVS
uniprot
proteins
function
FUNCTION: Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2 (PubMed:29138422, PubMed:29453251). Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway (PubMed:29138422). Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes (PubMed:29138422). Stimulation of macrophage migration and inhibition of osteoclast formation is mediated through the GPCR FPR2 (PubMed:29138422). Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling (By similarity). Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries (PubMed:29453251). {ECO:0000250|UniProtKB:M0R7X9, ECO:0000269|PubMed:29138422, ECO:0000269|PubMed:29453251}.
uniprot
proteins
mass_dalton
14331
uniprot
proteins
protein_family
TAFA family
uniprot
proteins
pubmed
15028294
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
29138422
uniprot
proteins
pubmed
29453251
uniprot
proteins
sequence_length
132
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29453251}.
uniprot
proteins