Appbp2
entrez
66884
canonical
uniprot
Q9DAX9
canonical
ensembl
ENSMUSG00000018481
resolver
ensp
ENSMUSP00000018625
resolver
enst
ENSMUST00000018625
resolver
genesymbol
Appbp2
resolver
genesymbol_syn
Kiaa0228
resolver
uniprot
Q5SX12
resolver
uniprot
Q80U61
resolver
uniprot_entry
APBP2_MOUSE
resolver
uniprot_sec
Q5SX12
resolver
uniprot_sec
Q80U61
resolver
activity_regulation
ACTIVITY REGULATION: E3 ubiquitin-protein ligase activity of the CRL2(APPBP2) complex is inhibited by APP. {ECO:0000250|UniProtKB:Q92624}.
uniprot
proteins
amino_acid_sequence
MAAVELEWIPETLYNTAISAVVDNYIRSRRDIRSLPENIQFDVYYKLYQQGRLCQLGSEFCELEVFAKVLRALDKRHLLHHCFQALMDHGVKVASVLAYSFSRRCSYIAESDAAVKEKAIQVGFVLGGFLSDAGWYSDAEKVFLSCLQLCTLHDEMLHWFRAVECCVRLLHVRNGNCKYHLGEETFKLAQTYMDKLSKHGQQANRAALYGELCALLFAKSHYDEAYKWCVEAMKEITAGLPVKVVVDVLRQASKACVVKREFKKAEQLIKHAVYLARDHFGSKHPKYSDTLLDYGFYLLNVDNICQSVAIYQAALDIRQSVFGGKNIHVATAHEDLAYSSYVHQYSSGKFDNALFHAERAIGIITHILPEDHLLLASSKRVKALILEEIAIDCHNKETEQRLLQEAHDLHLSSLQLAKKAFGEFNVQTAKHYGNLGRLYQSMRKFKEAEEMHIKAIQIKEQLLGQEDYEVALSVGHLASLYNYDMNQYENAEKLYLRSIAIGKKLFGEGYSGLEYDYRGLIKLYNSIGNYEKVFEYHNVLSNWNRLRDRQYSVTDALEDVSSSPQSTEEVVQSFLMAQNVEGPSC
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (By similarity). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (By similarity). The CRL2(APPBP2) complex specifically recognizes proteins with a -Arg-Xaa-Xaa-Gly degron at the C-terminus, leading to their ubiquitination and degradation (By similarity). The CRL2(APPBP2) complex mediates ubiquitination and degradation of truncated SELENOV selenoproteins produced by failed UGA/Sec decoding, which end with a -Arg-Xaa-Xaa-Gly degron (By similarity). The CRL2(APPBP2) complex negatively regulates beige adipocyte differentiation by mediating ubiquitination and degradation of PRDM16 (PubMed:35978186). May play a role in intracellular protein transport: may be involved in the translocation of APP along microtubules toward the cell surface (By similarity). {ECO:0000250|UniProtKB:Q92624, ECO:0000269|PubMed:35978186}.
uniprot
proteins
mass_dalton
66855
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:35978186}.
uniprot
proteins
post_translational_modification
PTM: Rapidly degraded by the proteasome upon overexpression of a C-terminal fragment of APP. {ECO:0000250|UniProtKB:Q92624}.
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
35978186
uniprot
proteins
sequence_length
585
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q92624}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q92624}. Membrane {ECO:0000250|UniProtKB:Q92624}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q92624}. Note=Associated with membranes and microtubules. {ECO:0000250|UniProtKB:Q92624}.
uniprot
proteins