SIDT2
entrez
51092
canonical
uniprot
Q8NBJ9
canonical
ensembl
ENSG00000149577
resolver
ensp
ENSP00000314023
resolver
genesymbol
SIDT2
resolver
hgnc
HGNC:24272
resolver
uniprot
Q8NBY7
resolver
uniprot
Q9Y357
resolver
uniprot_entry
SIDT2_HUMAN
resolver
uniprot_sec
Q8NBY7
resolver
uniprot_sec
Q9Y357
resolver
amino_acid_sequence
MFALGLPFLVLLVASVESHLGVLGPKNVSQKDAEFERTYVDEVNSELVNIYTFNHTVTRNRTEGVRVSVNVLNKQKGAPLLFVVRQKEAVVSFQVPLILRGMFQRKYLYQKVERTLCQPPTKNESEIQFFYVDVSTLSPVNTTYQLRVSRMDDFVLRTGEQFSFNTTAAQPQYFKYEFPEGVDSVIVKVTSNKAFPCSVISIQDVLCPVYDLDNNVAFIGMYQTMTKKAAITVQRKDFPSNSFYVVVVVKTEDQACGGSLPFYPFAEDEPVDQGHRQKTLSVLVSQAVTSEAYVSGMLFCLGIFLSFYLLTVLLACWENWRQKKKTLLVAIDRACPESGHPRVLADSFPGSSPYEGYNYGSFENVSGSTDGLVDSAGTGDLSYGYQGRSFEPVGTRPRVDSMSSVEEDDYDTLTDIDSDKNVIRTKQYLYVADLARKDKRVLRKKYQIYFWNIATIAVFYALPVVQLVITYQTVVNVTGNQDICYYNFLCAHPLGNLSAFNNILSNLGYILLGLLFLLIILQREINHNRALLRNDLCALECGIPKHFGLFYAMGTALMMEGLLSACYHVCPNYTNFQFDTSFMYMIAGLCMLKLYQKRHPDINASAYSAYACLAIVIFFSVLGVVFGKGNTAFWIVFSIIHIIATLLLSTQLYYMGRWKLDSGIFRRILHVLYTDCIRQCSGPLYVDRMVLLVMGNVINWSLAAYGLIMRPNDFASYLLAIGICNLLLYFAFYIIMKLRSGERIKLIPLLCIVCTSVVWGFALFFFFQGLSTWQKTPAESREHNRDCILLDFFDDHDIWHFLSSIAMFGSFLVLLTLDDDLDTVQRDKIYVF
uniprot
proteins
function
FUNCTION: Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported into lysosomes in an ATP-dependent manner, and degraded (PubMed:27046251, PubMed:27846365). Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis (PubMed:28277980). In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA. Binds long double-stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than 100 bp (By similarity). {ECO:0000250|UniProtKB:Q8CIF6, ECO:0000269|PubMed:27046251, ECO:0000269|PubMed:27846365, ECO:0000269|PubMed:28277980}.
uniprot
proteins
mass_dalton
94454
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250}.
uniprot
proteins
protein_family
SID1 family
uniprot
proteins
pubmed
10810093
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17897319
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
27046251
uniprot
proteins
pubmed
27846365
uniprot
proteins
pubmed
28277980
uniprot
proteins
sequence_length
832
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:28277980}; Multi-pass membrane protein {ECO:0000269|PubMed:17897319}. Cell membrane {ECO:0000269|PubMed:28277980}. Note=Mainly localizes to lysosomes and only partly to the plasma membrane (PubMed:28277980). Lysosomal localization is required for SIDT2-mediated intracellular degradation of endogenous RNA (By similarity). {ECO:0000250|UniProtKB:Q8CIF6, ECO:0000269|PubMed:28277980}.
uniprot
proteins
transmembrane_region
TRANSMEM 297..317; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 448..468; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 500..520; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 547..567; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 606..626; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 632..652; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 689..709; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 716..736; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 747..767; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 797..817; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins