Snapin
entrez
295217
canonical
uniprot
P60192
canonical
genesymbol
Snapin
resolver
genesymbol_syn
Bloc1s7
resolver
genesymbol_syn
Snap25bp
resolver
genesymbol_syn
Snapap
resolver
uniprot
Q4KM25
resolver
uniprot_entry
Q4KM25_RAT
resolver
uniprot_entry
SNAPN_RAT
resolver
amino_acid_sequence
MAAAGSAAVSGAGTPVAGPTGRDLFAEGLLEFLRPAVQQLDSHVHAVRESQVELREQIDNLATELCRINEDQKVALDLDPYVKKLLNARRRVVLVNNILQNAQERLRRLNHSVAKETARRRAMLDSGVYPPGSPSK
uniprot
proteins
function
FUNCTION: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling. May modulate a step between vesicle priming, fusion and calcium-dependent neurotransmitter release through its ability to potentiate the interaction of synaptotagmin with the SNAREs and the plasma-membrane-associated protein SNAP25. Its phosphorylation state influences exocytotic protein interactions and may regulate synaptic vesicle exocytosis. May also have a role in the mechanisms of SNARE-mediated membrane fusion in non-neuronal cells (PubMed:10195194, PubMed:11283605). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (By similarity). {ECO:0000250|UniProtKB:O95295, ECO:0000269|PubMed:10195194, ECO:0000269|PubMed:11283605}.
uniprot
proteins
mass_dalton
14904
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CSNK1D/CK1. {ECO:0000269|PubMed:11283605}.
uniprot
proteins
protein_family
SNAPIN family
uniprot
proteins
pubmed
10195194
uniprot
proteins
pubmed
11283605
uniprot
proteins
pubmed
12877659
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
16760431
uniprot
proteins
pubmed
18167355
uniprot
proteins
sequence_length
136
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9Z266}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9Z266}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Z266}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9Z266}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9Z266}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9Z266}. Lysosome membrane {ECO:0000250|UniProtKB:O95295}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:18167355}. Note=Colocalizes with NANOS1 and PUM2 in the perinuclear region of germ cells. {ECO:0000250|UniProtKB:O95295}.
uniprot
proteins