RAB7B
entrez
338382
canonical
uniprot
Q96AH8
canonical
ensembl
ENSG00000276600
resolver
ensp
ENSP00000479762
resolver
ensp
ENSP00000482499
resolver
ensp
ENSP00000485386
resolver
ensp
ENSP00000485468
resolver
ensp
ENSP00000537241
resolver
ensp
ENSP00000537242
resolver
enst
ENST00000617070
resolver
enst
ENST00000617991
resolver
enst
ENST00000623597
resolver
enst
ENST00000623893
resolver
enst
ENST00000867182
resolver
enst
ENST00000867183
resolver
genesymbol
RAB7B
resolver
hgnc
HGNC:30513
resolver
uniprot
A0A096LP44
resolver
uniprot_entry
A0A096LP44_HUMAN
resolver
uniprot_entry
RAB7B_HUMAN
resolver
amino_acid_sequence
MNPRKKVDLKLIIVGAIGVGKTSLLHQYVHKTFYEEYQTTLGASILSKIIILGDTTLKLQIWDTGGQERFRSMVSTFYKGSDGCILAFDVTDLESFEALDIWRGDVLAKIVPMEQSYPMVLLGNKIDLADRKVPQEVAQGWCREKDIPYFEVSAKNDINVVQAFEMLASRALSRYQSILENHLTESIKLSPDQSRSRCC
uniprot
proteins
function
FUNCTION: Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway. {ECO:0000269|PubMed:20375062, ECO:0000269|PubMed:20953574}.
uniprot
proteins
mass_dalton
22511
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15144907
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20375062
uniprot
proteins
pubmed
20953574
uniprot
proteins
pubmed
21057625
uniprot
proteins
pubmed
21255211
uniprot
proteins
pubmed
31636202
uniprot
proteins
sequence_length
199
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome {ECO:0000269|PubMed:20375062, ECO:0000269|PubMed:31636202}. Lysosome {ECO:0000269|PubMed:15144907, ECO:0000269|PubMed:20375062, ECO:0000269|PubMed:31636202}. Golgi apparatus {ECO:0000269|PubMed:20375062}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:20375062}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. {ECO:0000269|PubMed:21255211}.
uniprot
proteins