RIC8A
entrez
60626
canonical
uniprot
Q9NPQ8
canonical
ensembl
ENSG00000177963
resolver
ensp
ENSP00000325941
resolver
ensp
ENSP00000432008
resolver
ensp
ENSP00000434833
resolver
ensp
ENSP00000523301
resolver
genesymbol
RIC8A
resolver
hgnc
HGNC:29550
resolver
uniprot
Q0P508
resolver
uniprot
Q2T9J1
resolver
uniprot
Q7Z352
resolver
uniprot
Q96EZ1
resolver
uniprot
Q96SZ2
resolver
uniprot
Q9H064
resolver
uniprot
Q9H5H3
resolver
uniprot
Q9H9E7
resolver
uniprot_entry
RIC8A_HUMAN
resolver
uniprot_sec
Q0P508
resolver
uniprot_sec
Q2T9J1
resolver
uniprot_sec
Q7Z352
resolver
uniprot_sec
Q96EZ1
resolver
uniprot_sec
Q96SZ2
resolver
uniprot_sec
Q9H064
resolver
uniprot_sec
Q9H5H3
resolver
uniprot_sec
Q9H9E7
resolver
amino_acid_sequence
MEPRAVAEAVETGEEDVIMEALRSYNQEHSQSFTFDDAQQEDRKRLAELLVSVLEQGLPPSHRVIWLQSVRILSRDRNCLDPFTSRQSLQALACYADISVSEGSVPESADMDVVLESLKCLCNLVLSSPVAQMLAAEARLVVKLTERVGLYRERSFPHDVQFFDLRLLFLLTALRTDVRQQLFQELKGVRLLTDTLELTLGVTPEGNPPPTLLPSQETERAMEILKVLFNITLDSIKGEVDEEDAALYRHLGTLLRHCVMIATAGDRTEEFHGHAVNLLGNLPLKCLDVLLTLEPHGDSTEFMGVNMDVIRALLIFLEKRLHKTHRLKESVAPVLSVLTECARMHRPARKFLKAQVLPPLRDVRTRPEVGEMLRNKLVRLMTHLDTDVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLAARGLMAGGRPEGQYSEDEDTDTDEYKEAKASINPVTGRVEEKPPNPMEGMTEEQKEHEAMKLVTMFDKLSRNRVIQPMGMSPRGHLTSLQDAMCETMEQQLSSDPDSDPD
uniprot
proteins
function
FUNCTION: Chaperone that specifically binds and folds nascent G alpha proteins prior to G protein heterotrimer formation, promoting their stability and activity: folds GNAI1, GNAO1, GNA13 and GNAQ (By similarity). Does not fold G(s) G-alpha proteins GNAS nor GNAL (By similarity). Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP (By similarity). Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (GNAI1), possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (PubMed:16629901). {ECO:0000250|UniProtKB:Q80ZG1, ECO:0000269|PubMed:16629901}.
uniprot
proteins
mass_dalton
59710
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-436 and Thr-441 by CK2, stabilizing its interface with G alpha proteins. {ECO:0000250|UniProtKB:Q80ZG1}.
uniprot
proteins
protein_family
Synembryn family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16629901
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25074811
uniprot
proteins
pubmed
28119500
uniprot
proteins
pubmed
29966094
uniprot
proteins
sequence_length
531
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q80ZG1}. Cytoplasm {ECO:0000250|UniProtKB:Q80ZG1}.
uniprot
proteins