SNRPF
entrez
6636
canonical
uniprot
P62306
canonical
ensembl
ENSG00000139343
resolver
ensp
ENSP00000266735
resolver
ensp
ENSP00000770034
resolver
enst
ENST00000266735
resolver
genesymbol
SNRPF
resolver
genesymbol_syn
PBSCF
resolver
hgnc
HGNC:11162
resolver
uniprot
A2VCR2
resolver
uniprot
B2R498
resolver
uniprot
Q15356
resolver
uniprot
Q6IBQ1
resolver
uniprot
Q6P4I0
resolver
uniprot_entry
RUXF_HUMAN
resolver
uniprot_sec
A2VCR2
resolver
uniprot_sec
B2R498
resolver
uniprot_sec
Q15356
resolver
uniprot_sec
Q6IBQ1
resolver
uniprot_sec
Q6P4I0
resolver
amino_acid_sequence
MSLPLNPKPFLNGLTGKPVMVKLKWGMEYKGYLVSVDGYMNMQLANTEEYIDGALSGHLGEVLIRCNNVLYIRGVEEEEEDGEMRE
uniprot
proteins
function
FUNCTION: Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28076346, PubMed:28502770, PubMed:28781166, PubMed:32494006). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28076346, PubMed:28502770, PubMed:28781166). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (PubMed:15146077). As part of the U7 snRNP it is involved in histone 3'-end processing (PubMed:12975319). {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12975319, ECO:0000269|PubMed:15146077, ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:19325628, ECO:0000269|PubMed:23333303, ECO:0000269|PubMed:25555158, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:32494006}.
uniprot
proteins
mass_dalton
9725
uniprot
proteins
protein_family
SmF/LSm6 subfamily
uniprot
proteins
protein_family
SnRNP Sm proteins family
uniprot
proteins
pubmed
11574479
uniprot
proteins
pubmed
11991638
uniprot
proteins
pubmed
12975319
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15146077
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16314521
uniprot
proteins
pubmed
18984161
uniprot
proteins
pubmed
19325628
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21516107
uniprot
proteins
pubmed
21816274
uniprot
proteins
pubmed
23333303
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25555158
uniprot
proteins
pubmed
26912367
uniprot
proteins
pubmed
28076346
uniprot
proteins
pubmed
28502770
uniprot
proteins
pubmed
28781166
uniprot
proteins
pubmed
31799625
uniprot
proteins
pubmed
32494006
uniprot
proteins
pubmed
33509932
uniprot
proteins
pubmed
36797247
uniprot
proteins
pubmed
7744013
uniprot
proteins
sequence_length
86
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:11574479, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:28781166}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. {ECO:0000305}.
uniprot
proteins