Ercc6l
entrez
236930
canonical
uniprot
Q8BHK9
canonical
ensembl
ENSMUSG00000051220
resolver
ensp
ENSMUSP00000050592
resolver
enst
ENSMUST00000056904
resolver
genesymbol
Ercc6l
resolver
uniprot
Q8BGN1
resolver
uniprot
Q8BRC9
resolver
uniprot
Q8CE49
resolver
uniprot_entry
ERC6L_MOUSE
resolver
uniprot_sec
Q8BGN1
resolver
uniprot_sec
Q8BRC9
resolver
uniprot_sec
Q8CE49
resolver
amino_acid_sequence
MEASQGLAEVETLSPQLAESYLRYVQEAKEAAKNGDLEESLKLFNLAKDIFPTKKVMSRIQKLQEALEQLAEEEDDDEFIDVCSSGLLLYRELYEKLFEHQKEGIAFLYSLYKDGRKGGILADDMGLGKTVQIIAFLSGMFDASLVNHVLLIMPTNLINTWVNEFAKWTPGMRVKTFHGSSKSERTRSLTRIQQRNGVVITTYQMLLNNWQQLASFNGQAFVWDYVILDEAHKIKSASTKSAVCARAIPASNRLLLTGTPVQNNLQELWSLFDFACQGSLLGTLKTFKMEYEHPIIRAREKDATPGEKALGLKISENLMEIIKPYFLRRTKEEVQTKKADNPEARLGEKNPAGEAICDMFSLARKNDLIVWIRLLPLQEEIYRKFVSLDHIKELLMETRSPLAELGVLKKLCDHPRLLSARACRLLNLGTATFSAQDENEQEDVSNMNSIDHLPDKTLIQESGKMIFLMSLLERLQDEGHQTLVFSQSIKILNIIERLLKNKHFKTLRIDGTVTHLWEREKRIQLFQQNKEYSVFLLTTQVGGVGLTLTAATRVVIFDPSWNPATDAQAVDRVYRIGQKENVVVYRLITCGTVEEKIYRRQVFKDSLIRQTTGEKKNPFRYFTKQELKELFTVGDLQKSATQMQLQCLHAAQRRSDEKLDEHIAYLHLLGIAGISDHDLMFTRDLSVKEELDMLEDSQYIHQRVQKAQFLVESESQNTVQRQTTGIEETWLKAQEFPSQQKKKGTEFNKPQPQPSRLLTKPTQVEAISSQMASITICDQSAESEPQEHSEVHDVTSLQGSHHFNSTSDAGTIASLPQGAESIGEVSTDSLLSPAKGFAAENDAMQKKGLQASPGQEAPSENLGSFHYLPRESSKASLGPNLDLQDSVVLYHRSPTANENQNLESDVPMIEISDDLSEPPSALQGAQAIEAQLELKEDDPLKSPPQYACDFNLFLEDSADTRQNLSSKFLEHVEKEKSLQSPAANSRAKSALTLSLDSSPKSDEESEVISVKTKSKTRRILSDDEDEDEEDAFKGSHTNSINISPFPFSSVKQFDASTPQSGSNPSRRFFSPKTPGEVNTSLHSRRSLASRRSLINVVLDDVEDMEERLDNSSEEESEPGLSEENNEEEALACTEEQPSGATLASGNKSSNLTMSEPTSPAPQSSPCAPEPSSSDPMPDPPQDLAVEAGNDYESLVARGKELKECGKIQEALNCLVKALDIKSADPEVMLMTLSLYKQLNI
uniprot
proteins
ec_number
3.6.4.12
uniprot
proteins
function
FUNCTION: DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro). {ECO:0000250|UniProtKB:Q2NKX8}.
uniprot
proteins
mass_dalton
138854
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by PLK1 prevents the association with chromosome arms and restricts its localization to the kinetochore-centromere region. {ECO:0000250|UniProtKB:Q2NKX8}.
uniprot
proteins
protein_family
SNF2/RAD54 helicase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15917148
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1240
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome, centromere {ECO:0000250|UniProtKB:Q2NKX8}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q2NKX8}. Chromosome {ECO:0000250|UniProtKB:Q2NKX8}. Note=Localizes to kinetochores, inner centromeres and thin threads connecting separating chromosomes even during anaphase. In prometaphase cells, it mostly concentrates in between kinetochores. In metaphase, it localizes to numerous thin threads that stretch between sister kinetochores of the aligned chromosomes and are composed of catenated centromeric DNA. Evolution from inner centromeres to thin threads takes place in response to tension. Resolution of thin threads requires topoisomerase 2-alpha (TOP2A) after anaphase onset. {ECO:0000250|UniProtKB:Q2NKX8}.
uniprot
proteins