Slc22a17
entrez
305886
canonical
uniprot
Q9P290
canonical
ensembl
ENSRNOG00000016414
resolver
ensp
ENSRNOP00000096057
resolver
genesymbol
Slc22a17
resolver
genesymbol_syn
Boct
resolver
genesymbol_syn
Boit
resolver
uniprot
Q4KLP1
resolver
uniprot_entry
S22AH_RAT
resolver
uniprot_sec
Q4KLP1
resolver
amino_acid_sequence
MASDPIFTLAPPLHCHYGALPPNASGWEQPPNSSGVSVAGAALAASAASRVVTSTDPSCSGFAPPDFNHCLKDWDYNGLPVLTTNAIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTLGLVGPCGVGGAAAGSSTGIMTLRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERNRPHGQMLGEEAQEALQELENTCPLPTTSTFSFASLLNYRNIWKNLLILGFTNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDYLNDAAITTFSVLGLFSSQASAILSTLLAAEVIPTTVRGRGLGLIMALGALGGLSCPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLLPEVLRDGELCRRPSLLRQPPPNRCDHVPLLATPNPAL
uniprot
proteins
function
FUNCTION: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
55801
uniprot
proteins
protein_family
Major facilitator (TC 2.A.1) superfamily
uniprot
proteins
protein_family
Organic cation transporter (TC 2.A.1.19) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
520
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Vacuole membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Upon LCN2-binding, it is internalized. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 100..120; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 129..149; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 154..174; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 189..209; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 219..239; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 303..322; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 337..357; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 366..386; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 397..417; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 428..448; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 455..475; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins