Fto
entrez
291905
canonical
uniprot
Q2A121
canonical
ensembl
ENSRNOG00000011728
resolver
ensembl
ENSRNOG00055019709
resolver
ensembl
ENSRNOG00060016604
resolver
ensembl
ENSRNOG00065014588
resolver
ensp
ENSRNOP00000015718
resolver
ensp
ENSRNOP00055027296
resolver
ensp
ENSRNOP00060022934
resolver
ensp
ENSRNOP00065018810
resolver
enst
ENSRNOT00000015718
resolver
enst
ENSRNOT00055033646
resolver
enst
ENSRNOT00060028496
resolver
enst
ENSRNOT00065024108
resolver
genesymbol
Fto
resolver
uniprot
B4F7E0
resolver
uniprot_entry
B4F7E0_RAT
resolver
uniprot_entry
FTO_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by ascorbate. Inhibited by N-oxalylglycine, fumarate and succinate. {ECO:0000250|UniProtKB:Q8BGW1}.
uniprot
proteins
amino_acid_sequence
MKRVQTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLVFREAGSIPEELHKEVPEAFLTLHKHGCLFRDLVRIQGKDVLTPVSRILIGDPGCTYKYLNTRLFTVPWPVKGCTINYTEAEIAAACQTFLKLNDYLQVETIQALEELAIKEKANEDAVPLCMAEFPRAGVGPSCDDEVDLKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGSEDESDDESSFEGRDPDTWHVGFKISWDIETPGLTIPLHQGDCYFMLDDLNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILQRCQLALQNVLNDSDNGDVSLKSFEPAVLKQGEEIHNEVEFEWLRQFWFQGNRYKICTDWWCEPMTQLEGLWKKMESVTNAVLREVKREGLSVEQRSEILSAVLIPLTMRQNLRKEWHARCQARVVRTLPAQQKPDCRPYWEKDDPSMPLPFDLTDVVSEIRSQLLEARS
uniprot
proteins
ec_number
1.14.11.-
uniprot
proteins
ec_number
1.14.11.53
uniprot
proteins
function
FUNCTION: RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis. Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. M6A demethylation by FTO affects mRNA expression and stability. Also able to demethylate m6A in U6 small nuclear RNA (snRNA). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)-methyladenosine at the second transcribed position of mRNAs and U6 snRNA. Demethylation of m6A(m) in the 5'-cap by FTO affects mRNA stability by promoting susceptibility to decapping. Also acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs. Has no activity towards 1-methylguanine. Has no detectable activity towards double-stranded DNA. Also able to repair alkylated DNA and RNA by oxidative demethylation: demethylates single-stranded RNA containing 3-methyluracil, single-stranded DNA containing 3-methylthymine and has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine. Ability to repair alkylated DNA and RNA is however unsure in vivo. Involved in the regulation of fat mass, adipogenesis and body weight, thereby contributing to the regulation of body size and body fat accumulation. Involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells (By similarity). Regulates activity of the dopaminergic midbrain circuitry via its ability to demethylate m6A in mRNAs (By similarity). {ECO:0000250|UniProtKB:Q8BGW1, ECO:0000250|UniProtKB:Q9C0B1}.
uniprot
proteins
mass_dalton
57972
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by DTX2; leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q9C0B1}.
uniprot
proteins
protein_family
Fto family
uniprot
proteins
pubmed
17143547
uniprot
proteins
pubmed
18218688
uniprot
proteins
sequence_length
502
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9C0B1}. Nucleus speckle {ECO:0000250|UniProtKB:Q9C0B1}. Cytoplasm {ECO:0000250|UniProtKB:Q9C0B1}. Note=Localizes mainly in the nucleus, where it is able to demethylate N(6)-methyladenosine (m6A) and N(6),2'-O-dimethyladenosine cap (m6A(m)) in U6 small nuclear RNA (snRNA), N(1)-methyladenine from tRNAs and internal m6A in mRNAs. In the cytoplasm, mediates demethylation of m6A and m6A(m) in mRNAs and N(1)-methyladenine from tRNAs. {ECO:0000250|UniProtKB:Q9C0B1}.
uniprot
proteins