Pcsk1n
entrez
246333
canonical
uniprot
Q9QXU9
canonical
ensembl
ENSRNOG00000046021
resolver
ensembl
ENSRNOG00055027142
resolver
ensembl
ENSRNOG00060025182
resolver
ensembl
ENSRNOG00065011262
resolver
ensp
ENSRNOP00000066891
resolver
ensp
ENSRNOP00055038543
resolver
ensp
ENSRNOP00060036134
resolver
ensp
ENSRNOP00065013941
resolver
enst
ENSRNOT00055046920
resolver
enst
ENSRNOT00060043587
resolver
enst
ENSRNOT00065018262
resolver
genesymbol
Pcsk1n
resolver
uniprot_entry
PCS1N_RAT
resolver
amino_acid_sequence
MAGSPLLCGPRAGGVGLLVLLLLGLLRLPPTLSARPVKEPRSLSAASAPLAETSTPLRLRRAVPRGEAAGAVQELARALAHLLEAERQERARAEAQEAEDQQARVLAQLLRAWGSPRASDPPLAPDDDPDAPAAQLARALLRARLDPAALAAQLVPAPAPAAALRPRPPVYDDGPTGPDVEDAADETPDVDPELLRYLLGRILTGSSEPEAAPAPRRLRRAVDQDLGPEVPPENVLGALLRVKRLENSSPQAPARRLLPP
uniprot
proteins
function
FUNCTION: May act as a protein chaperone that prevents the aggregation of client proteins and plays a role in neuroprotection. Blocks the trans-synaptic spread of SNCA/alpha-synuclein in the brain. May form spheres that encapsulate client proteins. May prevent aggregation of amyloid beta and SNCA/alpha-synuclein. Cannot disaggregate preformed fibrils. Additionally, may regulate the neuroendocrine secretory pathway by acting as a specific endogenous inhibitor of PCSK1 (PubMed:10632593, PubMed:10816562). ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, reduce the activity of the 87 kDa form of PCSK1, but not the autocatalytically derived 66 kDa form, in the endoplasmic reticulum and Golgi (PubMed:10632593, PubMed:10816562). May control the intracellular timing of PCSK1 rather than its total level of activity and slows down convertase-mediated processing of proopiomelanocortin and proenkephalin (By similarity). {ECO:0000250|UniProtKB:Q9QXV0, ECO:0000269|PubMed:10632593, ECO:0000269|PubMed:10816562}.; FUNCTION: [Big LEN]: Endogenous ligand for GPR171. Neuropeptide involved in the regulation of feeding. {ECO:0000250|UniProtKB:Q9QXV0}.; FUNCTION: [PEN]: Endogenous ligand for GPR83. Neuropeptide involved in the regulation of feeding. {ECO:0000250|UniProtKB:Q9QXV0}.
uniprot
proteins
mass_dalton
27414
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved in the Golgi. Big SAAS, Little SAAS, PEN and Big LEN are the major processed peptides in proSAAS-overexpressing PC-12 phaeochromocytoma cells (lacking PCSK1 and PCSK2 endopeptidases). Peptides corresponding to PEN and a proSAAS aa 40-59 have been detected in wild-type PC-12 cells. {ECO:0000269|PubMed:11742530}.
uniprot
proteins
pubmed
10632593
uniprot
proteins
pubmed
10816562
uniprot
proteins
pubmed
11742530
uniprot
proteins
pubmed
15935061
uniprot
proteins
pubmed
9630436
uniprot
proteins
sequence_length
260
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9QXV0}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q9QXV0}. Note=Proteotoxic stress stimulates its intracellular retention. {ECO:0000250|UniProtKB:Q9QXV0}.
uniprot
proteins