TIAL1
entrez
7073
canonical
uniprot
Q01085
canonical
ensembl
ENSG00000151923
resolver
ensp
ENSP00000358089
resolver
ensp
ENSP00000394902
resolver
ensp
ENSP00000677225
resolver
genesymbol
TIAL1
resolver
hgnc
HGNC:11804
resolver
uniprot
A8K3T0
resolver
uniprot
A8K4L9
resolver
uniprot
Q49AS9
resolver
uniprot_entry
Q49AS9_HUMAN
resolver
uniprot_entry
TIAR_HUMAN
resolver
uniprot_sec
A8K3T0
resolver
uniprot_sec
A8K4L9
resolver
amino_acid_sequence
MMEDDGQPRTLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEHTSNDPYCFVEFYEHRDAAAALAAMNGRKILGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQENNTKQLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPEKGYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQVDYSQWGQWSQVYGNPQQYGQYMANGWQVPPYGVYGQPWNQQGFGVDQSPSAAWMGGFGAQPPQGQAPPPVIPPPNQAGYGMASYQTQ
uniprot
proteins
function
FUNCTION: RNA-binding protein involved in alternative pre-RNA splicing and in cytoplasmic stress granules formation (PubMed:10613902, PubMed:1326761, PubMed:17488725, PubMed:8576255). Shows a preference for uridine-rich RNAs (PubMed:8576255). Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIA1 mRNA (By similarity). Promotes the inclusion of TIA1 exon 5 to give rise to the long isoform (isoform a) of TIA1 (PubMed:17488725). Acts downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SG) (PubMed:10613902). Possesses nucleolytic activity against cytotoxic lymphocyte target cells (PubMed:1326761). May be involved in apoptosis (PubMed:1326761). {ECO:0000250|UniProtKB:P70318, ECO:0000269|PubMed:10613902, ECO:0000269|PubMed:1326761, ECO:0000269|PubMed:17488725, ECO:0000269|PubMed:8576255}.
uniprot
proteins
mass_dalton
41591
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MAPK14 following DNA damage, releasing TIAR from GADD45A mRNA. {ECO:0000269|PubMed:20932473}.
uniprot
proteins
pubmed
10613902
uniprot
proteins
pubmed
1326761
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
17135269
uniprot
proteins
pubmed
17488725
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20932473
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
8576255
uniprot
proteins
sequence_length
375
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10613902}. Cytoplasm {ECO:0000250|UniProtKB:P70318}. Cytolytic granule {ECO:0000269|PubMed:1326761}. Cytoplasm, Stress granule {ECO:0000269|PubMed:10613902, ECO:0000269|PubMed:18691976}. Note=Nuclear import seems to be coupled to RNA polymerase II transcription and may be dependent on RNA-binding (By similarity). Accumulates in cytoplasmic stress granules (SG) following cellular damage (PubMed:10613902). {ECO:0000250|UniProtKB:P70318, ECO:0000269|PubMed:10613902}.
uniprot
proteins