Gpr3
entrez
266769
canonical
uniprot
Q8K1Q3
canonical
ensembl
ENSRNOG00000009540
resolver
ensembl
ENSRNOG00055024360
resolver
ensembl
ENSRNOG00060027503
resolver
ensembl
ENSRNOG00065028905
resolver
ensp
ENSRNOP00000068417
resolver
ensp
ENSRNOP00000101830
resolver
ensp
ENSRNOP00000102027
resolver
ensp
ENSRNOP00000102818
resolver
ensp
ENSRNOP00000104730
resolver
ensp
ENSRNOP00000108661
resolver
ensp
ENSRNOP00055034096
resolver
ensp
ENSRNOP00060039670
resolver
ensp
ENSRNOP00065040988
resolver
enst
ENSRNOT00000076866
resolver
enst
ENSRNOT00000129793
resolver
enst
ENSRNOT00000134970
resolver
enst
ENSRNOT00000151370
resolver
enst
ENSRNOT00000153866
resolver
enst
ENSRNOT00000163829
resolver
enst
ENSRNOT00055041858
resolver
enst
ENSRNOT00060047693
resolver
enst
ENSRNOT00065049906
resolver
genesymbol
Gpr3
resolver
uniprot
Q63230
resolver
uniprot_entry
GPR3_RAT
resolver
uniprot_sec
Q63230
resolver
activity_regulation
ACTIVITY REGULATION: GPR3 bound to the lipid agonist is in an equilibrium between monomeric and dimeric states. G protein engagement leads to dissociation of the dimer, and efficient coupling and signaling of the Gs protein. {ECO:0000250|UniProtKB:P46089}.
uniprot
proteins
amino_acid_sequence
MMWGAGRSMAWFSAGSGSVNVSIDPAEEPTGPATLLPSPRAWDVVLCISGTLVSCENALVVAIIVGTPAFRAPMFLLVGSLAVADLLAGLGLVLHFAADFCIGSPEMSLVLVGVLATAFTASIGSLLAITVDRYLSLYNALTYYSETTVTRTYVMLALVWVGALGLGLVPVLAWNCRDGLTTCGVVYPLSKNHLVVLAIVFFMVFGIMLQLYAQICRIVCRHAQQIALQRHLLPASHYVATRKGIATLAVVLGAFAACWLPFTVYCLLGDANSPPLYTYLTLLPATYNSMINPVIYAFRNQDVQKVLWAICCCCSTSKIPFRSRSPSDV
uniprot
proteins
function
FUNCTION: Constitutively active G protein-coupled receptor that maintains high cAMP levels and contributes to several processes, including meiotic arrest in oocytes and neuronal development, through activation of intracellular signaling pathways (PubMed:17284443). Essential activator of thermogenic adipocytes, where it drives thermogenesis via constitutive G(s)-coupling activity in the absence of ligand. May be activated by lipid-derived agonists such as oleoylethanolamide (OEA), oleic acid or sphingosine 1-phosphate leading to activation of the G(s)/cAMP/PKA signaling pathway (By similarity). Plays a potential role in modulating brain functions, including behavioral responses to stress and amyloid-beta peptide generation in neurons (By similarity). Stimulates neurite outgrowth in cerebellar granule neurons via PKA, ERK, and PI3K-mediated signaling pathways (PubMed:34871769). {ECO:0000250|UniProtKB:P35413, ECO:0000250|UniProtKB:P46089, ECO:0000269|PubMed:17284443, ECO:0000269|PubMed:34871769}.
uniprot
proteins
mass_dalton
35327
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12220620
uniprot
proteins
pubmed
17284443
uniprot
proteins
pubmed
34871769
uniprot
proteins
pubmed
7698767
uniprot
proteins
sequence_length
329
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 44..64; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 74..94; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 109..129; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 154..174; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 193..213; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 248..268; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 278..298; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins