Cask
entrez
29647
canonical
uniprot
Q62915
canonical
ensembl
ENSRNOG00000060946
resolver
ensp
ENSRNOP00000004187
resolver
ensp
ENSRNOP00000072295
resolver
ensp
ENSRNOP00000074587
resolver
ensp
ENSRNOP00000095774
resolver
ensp
ENSRNOP00000096945
resolver
enst
ENSRNOT00000004187
resolver
enst
ENSRNOT00000082316
resolver
enst
ENSRNOT00000097626
resolver
enst
ENSRNOT00000099608
resolver
genesymbol
Cask
resolver
uniprot
A0A0G2K8F4
resolver
uniprot
A0A8I6APQ1
resolver
uniprot
A0A8I6GLU3
resolver
uniprot
D4A8M2
resolver
uniprot_entry
A0A0G2K8F4_RAT
resolver
uniprot_entry
A0A8I6APQ1_RAT
resolver
uniprot_entry
A0A8I6GLU3_RAT
resolver
uniprot_entry
CSKP_RAT
resolver
uniprot_entry
D4A8M2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Differs from archetypal CaMK members in that the kinase domain exhibits a constitutively active conformation and the autoinhibitory region does not engage in direct contact with the ATP-binding cleft, although it still binds Ca(2+)/CAM. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKFNSFYGDPPEELPDFSEDPTSSGLLAAERAVSQVLDSLEEIHALTDCSEKDLDFLHSVFQDQHLHTLLDLYDKINTKSSPQIRNPPSDAVQRAKEVLEEISCYPENNDAKELKRILTQPHFMALLQTHHVVAHEVYSDEALRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNADLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPERFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFPPFVVFIAAPTITPGLNEDESLQRLQKESDVLQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVPVSWVY
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Multidomain scaffolding Mg(2+)-independent protein kinase that catalyzes the phosphotransfer from ATP to proteins such as NRXN1, and plays a role in synaptic transmembrane protein anchoring and ion channel trafficking (By similarity). Multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking.ontributes to neural development and regulation of gene expression via interaction with the transcription factor TBR1. Binds to cell-surface proteins, including amyloid precursor protein, neurexins, and syndecans. May mediate a link between the extracellular matrix and the actin cytoskeleton via its interaction with syndecan and with the actin/spectrin-binding protein 4.1. Component of the LIN-10-LIN-2-LIN-7 complex, which associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). {ECO:0000250|UniProtKB:O14936, ECO:0000250|UniProtKB:O70589, ECO:0000269|PubMed:10749215}.
uniprot
proteins
mass_dalton
103259
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
CaMK subfamily; MAGUK family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10749215
uniprot
proteins
pubmed
11865057
uniprot
proteins
pubmed
12040031
uniprot
proteins
pubmed
12151521
uniprot
proteins
pubmed
12641734
uniprot
proteins
pubmed
14627983
uniprot
proteins
pubmed
15048107
uniprot
proteins
pubmed
15994232
uniprot
proteins
pubmed
25385611
uniprot
proteins
pubmed
8786425
uniprot
proteins
pubmed
9753324
uniprot
proteins
sequence_length
909
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10749215}. Cytoplasm {ECO:0000269|PubMed:12641734, ECO:0000269|PubMed:15994232}. Cell membrane {ECO:0000269|PubMed:14627983}; Peripheral membrane protein {ECO:0000269|PubMed:14627983}.
uniprot
proteins