ENPP3
entrez
5169
canonical
uniprot
O14638
canonical
ensembl
ENSG00000154269
resolver
ensp
ENSP00000350265
resolver
ensp
ENSP00000350964
resolver
ensp
ENSP00000406261
resolver
ensp
ENSP00000616725
resolver
enst
ENST00000357639
resolver
enst
ENST00000358229
resolver
enst
ENST00000414305
resolver
enst
ENST00000946666
resolver
genesymbol
ENPP3
resolver
genesymbol_syn
PDNP3
resolver
hgnc
HGNC:3358
resolver
uniprot
F8W6H5
resolver
uniprot
Q5JTL3
resolver
uniprot_entry
ENPP3_HUMAN
resolver
uniprot_entry
F8W6H5_HUMAN
resolver
uniprot_sec
Q5JTL3
resolver
amino_acid_sequence
MESTLTLATEQPVKKNTLKKYKIACIVLLALLVIMSLGLGLGLGLRKLEKQGSCRKKCFDASFRGLENCRCDVACKDRGDCCWDFEDTCVESTRIWMCNKFRCGETRLEASLCSCSDDCLQRKDCCADYKSVCQGETSWLEENCDTAQQSQCPEGFDLPPVILFSMDGFRAEYLYTWDTLMPNINKLKTCGIHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVNLNKNFSLSSKEQNNPAWWHGQPMWLTAMYQGLKAATYFWPGSEVAINGSFPSIYMPYNGSVPFEERISTLLKWLDLPKAERPRFYTMYFEEPDSSGHAGGPVSARVIKALQVVDHAFGMLMEGLKQRNLHNCVNIILLADHGMDQTYCNKMEYMTDYFPRINFFYMYEGPAPRIRAHNIPHDFFSFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVRIDKVHLFVDQQWLAVRSKSNTNCGGGNHGYNNEFRSMEAIFLAHGPSFKEKTEVEPFENIEVYNLMCDLLRIQPAPNNGTHGSLNHLLKVPFYEPSHAEEVSKFSVCGFANPLPTESLDCFCPHLQNSTQLEQVNQMLNLTQEEITATVKVNLPFGRPRVLQKNVDHCLLYHREYVSGFGKAMRMPMWSSYTVPQLGDTSPLPPTVPDCLRADVRVPPSESQKCSFYLADKNITHGFLYPPASNRTSDSQYDALITSNLVPMYEEFRKMWDYFHSVLLIKHATERNGVNVVSGPIFDYNYDGHFDAPDEITKHLANTDVPIPTHYFVVLTSCKNKSHTPENCPGWLDVLPFIIPHRPTNVESCPEGKPEALWVEERFTAHIARVRDVELLTGLDFYQDKVQPVSEILQLKTYLPTFETTI
uniprot
proteins
ec_number
3.1.4.1
uniprot
proteins
ec_number
3.6.1.-
uniprot
proteins
ec_number
3.6.1.9
uniprot
proteins
function
FUNCTION: Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (PubMed:29717535, PubMed:9344668). Also hydrolyzes extracellular 2',3'-cGAMP (cyclic GMP-AMP), a second messenger that activates TMEM173/STING and triggers type-I interferon production, and is therefore involved in the regulation of innate immune response (PubMed:38749434). 2',3'-cGAMP appears to be further processed to GMP, AMP and inorganic phosphate (PubMed:38749434). Limits mast cells and basophils response during inflammation and during the chronic phases of allergic responses by eliminating extracellular ATP, a signaling molecule activating these cells in an autocrine manner. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells (By similarity). Has a broad specificity and can also hydrolyze UDP-GlcNAc into UMP and GlcNAc-1-phosphate and potentially several other intracellular nucleotide sugars, including UDP-GalNAc, CMP-NeuAc, GDP-Fuc, and UDP-GlcA. Thereby, could modulate glycan biosynthesis and protein glycosylation (By similarity). Can hydrolyze extracellular dinucleoside polyphosphates, including the vasoactive adenosine polyphosphates as well (PubMed:12846830). In addition, displays an alkaline phosphodiesterase activity in vitro (PubMed:11342463). {ECO:0000250|UniProtKB:Q6DYE8, ECO:0000269|PubMed:11342463, ECO:0000269|PubMed:12846830, ECO:0000269|PubMed:29717535, ECO:0000269|PubMed:38749434, ECO:0000269|PubMed:9344668}.
uniprot
proteins
mass_dalton
100124
uniprot
proteins
mutagenesis
MUTAGEN 179; /note="T->C: Causes the formation of covalently linked homodimers in solution; when associated with C-336."; /evidence="ECO:0000269|PubMed:29717535"; MUTAGEN 204; /note="K->A: Strongly decreases affinity for nucleotides and slows their hydrolysis."; /evidence="ECO:0000269|PubMed:29717535"; MUTAGEN 227; /note="N->A: No effect on affinity for nucleotides and enzyme activity."; /evidence="ECO:0000269|PubMed:29717535"; MUTAGEN 275; /note="E->A: No effect on substrate specificity. Increases affinity for nucleotides and slows their hydrolysis."; /evidence="ECO:0000269|PubMed:29717535"; MUTAGEN 336; /note="A->C: Causes the formation of covalently linked homodimers in solution; when associated with C-179."; /evidence="ECO:0000269|PubMed:29717535
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. N-glycosylation is necessary for normal transport to the cell membrane, but is not the apical targeting signal. {ECO:0000250|UniProtKB:P97675}.
uniprot
proteins
protein_family
Nucleotide pyrophosphatase/phosphodiesterase family
uniprot
proteins
pubmed
11342463
uniprot
proteins
pubmed
12846830
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15031605
uniprot
proteins
pubmed
15072822
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
29717535
uniprot
proteins
pubmed
38749434
uniprot
proteins
pubmed
9344668
uniprot
proteins
sequence_length
875
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11342463, ECO:0000269|PubMed:12846830}; Single-pass type II membrane protein {ECO:0000305|PubMed:29717535}. Apical cell membrane {ECO:0000269|PubMed:15072822}; Single-pass type II membrane protein {ECO:0000305|PubMed:29717535}. Secreted {ECO:0000269|PubMed:15072822}. Note=Detected at the cell surface of basophils (PubMed:11342463). Detected at the apical plasma membrane of bile duct cells (PubMed:15072822). Located to the apical surface in intestinal and kidney epithelial cells. Secreted in serum, and in lumen of epithelial cells. {ECO:0000269|PubMed:11342463, ECO:0000269|PubMed:15072822}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..30; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins