Slc18a2
entrez
25549
canonical
uniprot
Q01827
canonical
ensembl
ENSRNOG00000008890
resolver
ensp
ENSRNOP00000011983
resolver
enst
ENSRNOT00000011983
resolver
genesymbol
Slc18a2
resolver
genesymbol_syn
Svat
resolver
genesymbol_syn
Vmat2
resolver
uniprot
A0A0G2JSJ6
resolver
uniprot
Q9QVP1
resolver
uniprot_entry
A0A0G2JSJ6_RAT
resolver
uniprot_entry
VMAT2_RAT
resolver
uniprot_sec
Q9QVP1
resolver
activity_regulation
ACTIVITY REGULATION: Strongly inhibited by reserpine and tetrabenazine (By similarity). Also inhibited to a lesser extent by ketanserin and fenfluramine (By similarity). Reserpine and ketanserin inhibit by blocking the substrate-binding pocket (By similarity). Tetrabenazine traps SLC18A2/VMAT2 in an occluded conformation and its inhibition is specific to SLC18A2/VMAT2 but not SLC18A1/VMAT1 (By similarity). {ECO:0000250|UniProtKB:Q05940, ECO:0000269|PubMed:25355561, ECO:0000269|PubMed:8125935, ECO:0000269|PubMed:8606801}.
uniprot
proteins
amino_acid_sequence
MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNSTEIQTTRPELVVSTSESIFSYYNNSTVLITGNATGTLPGGQSHKATSTQHTVANTTVPSDCPSEDRDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGKPMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMVIVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIAFAPLCFFLRSPPAKEEKMAILMDHNCPIKRKMYTQNNVQSYPIGDDEESESD
uniprot
proteins
function
FUNCTION: Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports a variety of catecholamines such as dopamine, adrenaline and noradrenaline, histamine, and indolamines such as serotonin (PubMed:1438304, PubMed:25355561, PubMed:8125935, PubMed:8606801, PubMed:8860238). Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates somatodendritic dopamine release in hippocampal neurons, likely as part of a regulated secretory pathway that integrates retrograde synaptic signals (PubMed:16301178). Acts as a primary transporter for striatal dopamine loading ensuring impulse-dependent release of dopamine at the synaptic cleft (By similarity). Responsible for histamine and serotonin storage and subsequent corelease from mast cell granules (By similarity) (PubMed:8860238). {ECO:0000250|UniProtKB:Q8BRU6, ECO:0000269|PubMed:1438304, ECO:0000269|PubMed:16301178, ECO:0000269|PubMed:8125935, ECO:0000269|PubMed:8606801, ECO:0000269|PubMed:8860238}.
uniprot
proteins
mass_dalton
55690
uniprot
proteins
mutagenesis
MUTAGEN 180..182; /note="SSS->AAA: Loss of activity. Abolishes histamine uptake."; /evidence="ECO:0000269|PubMed:8606801"; MUTAGEN 477; /note="K->A: Does not alter sorting to large dense granules."; /evidence="ECO:0000269|PubMed:16301178"; MUTAGEN 478..479; /note="EE->AA: Impairs sorting to large dense granules. Delivered to the plasma membrane instead. Abolishes exocytosis in dendrites. Reduces exocytosis in axons."; /evidence="ECO:0000269|PubMed:16301178"; MUTAGEN 480; /note="K->A: Does not alter sorting to large dense granules."; /evidence="ECO:0000269|PubMed:16301178"; MUTAGEN 481; /note="M->A: Does not alter sorting to large dense granules."; /evidence="ECO:0000269|PubMed:16301178"; MUTAGEN 483..484; /note="IL->AA: Impairs sorting to large dense granules. Delivered to the plasma membrane instead."; /evidence="ECO:0000269|PubMed:16301178
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Vesicular transporter family
uniprot
proteins
pubmed
1438304
uniprot
proteins
pubmed
1505023
uniprot
proteins
pubmed
16301178
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
25355561
uniprot
proteins
pubmed
8125935
uniprot
proteins
pubmed
8606801
uniprot
proteins
pubmed
8745292
uniprot
proteins
pubmed
8860238
uniprot
proteins
pubmed
9045708
uniprot
proteins
sequence_length
515
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:16301178}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:16301178}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000269|PubMed:16301178}. Cell projection, dendrite {ECO:0000269|PubMed:16301178}. Note=Sorted to large dense core granules in neuroendocrine cells, presumably at the level of the trans-Golgi network. In neurons it is predominantly detected in somatodendritic tubulovesicular membranes, a distinct population of secretory vesicles that undergo calcium-dependent exocytosis in axons and dendrites upon depolarization. Localized at synaptic vesicles in axons. {ECO:0000269|PubMed:16301178}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..41; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q05940"; TRANSMEM 131..151; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q05940"; TRANSMEM 161..181; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q05940"; TRANSMEM 191..211; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q05940"; TRANSMEM 221..243; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q05940"; TRANSMEM 250..272; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q05940"; TRANSMEM 293..312; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q05940"; TRANSMEM 330..353; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q05940"; TRANSMEM 359..379; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q05940"; TRANSMEM 391..411; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q05940"; TRANSMEM 416..436; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q05940"; TRANSMEM 442..463; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:Q05940
uniprot
proteins