BNIP3
entrez
664
canonical
uniprot
Q12983
canonical
ensembl
ENSG00000176171
resolver
ensp
ENSP00000357625
resolver
enst
ENST00000368636
resolver
genesymbol
BNIP3
resolver
genesymbol_syn
NIP3
resolver
hgnc
HGNC:1084
resolver
uniprot
O14620
resolver
uniprot
Q6NVY4
resolver
uniprot
Q96GP0
resolver
uniprot_entry
BNIP3_HUMAN
resolver
uniprot_entry
Q6NVY4_HUMAN
resolver
uniprot_sec
O14620
resolver
uniprot_sec
Q96GP0
resolver
amino_acid_sequence
MSQNGAPGMQEESLQGSWVELHFSNNGNGGSVPASVSIYNGDMEKILLDAQHESGRSSSKSSHCDSPPRSQTPQDTNRASETDTHSIGEKNSSQSEEDDIERRKEVESILKKNSDWIWDWSSRPENIPPKEFLFKHPKRTATLSMRNTSVMKKGGIFSAEFLKVFLPSLLLSHLLAIGLGIYIGRRLTTSTSTF
uniprot
proteins
function
FUNCTION: Apoptosis-inducing protein that can overcome BCL2 suppression. May play a role in repartitioning calcium between the two major intracellular calcium stores in association with BCL2. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates in mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Plays an important role in the calprotectin (S100A8/A9)-induced cell death pathway. {ECO:0000269|PubMed:19935772, ECO:0000269|PubMed:22292033}.
uniprot
proteins
mass_dalton
21541
uniprot
proteins
protein_family
NIP3 family
uniprot
proteins
pubmed
10381623
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15868100
uniprot
proteins
pubmed
18371312
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19935772
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22292033
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
38992176
uniprot
proteins
pubmed
7954800
uniprot
proteins
pubmed
9396766
uniprot
proteins
pubmed
9575197
uniprot
proteins
sequence_length
194
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion. Mitochondrion outer membrane; Single-pass membrane protein. Note=Coexpression with the EIB 19-kDa protein results in a shift in NIP3 localization pattern to the nuclear envelope. Colocalizes with ACAA2 in the mitochondria. Colocalizes with SPATA18 at the mitochondrion outer membrane.
uniprot
proteins
transmembrane_region
TRANSMEM 164..184; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins