Thbs4
entrez
21828
canonical
uniprot
Q9Z1T2
canonical
ensembl
ENSMUSG00000021702
resolver
ensp
ENSMUSP00000022213
resolver
enst
ENSMUST00000022213
resolver
genesymbol
Thbs4
resolver
genesymbol_syn
Tsp4
resolver
uniprot
B2RTL6
resolver
uniprot
Q9QYS3
resolver
uniprot
Q9WUE0
resolver
uniprot_entry
B2RTL6_MOUSE
resolver
uniprot_entry
TSP4_MOUSE
resolver
uniprot_sec
Q9QYS3
resolver
uniprot_sec
Q9WUE0
resolver
amino_acid_sequence
MPAPRAAAAAFLLLHLVLQPWQRTSAQATPQVFDLLPSSSQRLNPSALQPVLTDPTLHEVYLISTFKLQSKSSATIFGLYSSSDNSKYFEFTVMGRLNKAILRYLKNDGKIHLVVFNNLQLADGRRHRVLLRLSNLQRGDGSVELYLDCAQADSVRNLPRAFSGLTQNPESIELRTFQRKPQDFLEELKLVVRGSLFQVASLQDCFLQQSEPLAATSTGDFNRQFLGQMTQLNQLLGEVKDLLRQQVKETSFLRNTIAECQACGPLSFQSPTPNTLVPIAPPAPPTRPTRHCDSSPCFRGVRCTDTRDGFQCGPCPDGYTGNGITCSDVDECKYHPCYPGVRCVNLAPGFRCDACPVGFTGPMVQGVGINFAKTNKQVCTDVDECQNGACVLNSICINTLGSYRCGPCKPGYTGDQTRGCKTERSCRNPEQNPCSVHAQCIEERQGDVTCVCGVGWAGDGYVCGKDVDIDSYPDEELPCSARNCKKDNCKYVPNSGQEDADRDGIGDACDEDADGDGILNEQDNCVLTHNIDQRNSDKDIFGDACDNCRMVLNNDQKDTDGDGRGDACDDDMDGDGIKNILDNCPRVPNRDQQDRDGDDVGDACDSCPDVSNPNQSDVDNDLVGDSCDTNQDSDGDGHQDSTDNCPTVINSSQLDTDKDGIGDECDDDDDNDGIPDLVPPGPDNCRLVPNPAQEDSNNDGVGDICEADFDQDQVIDHIDVCPENAEITLTDFRAYQTVVLDPEGDAQIDPNWVVLNQGMEIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTQTDDDYAGFIFGYQDSSSFYVVMWKQTEQTYWQATPFRAVAEPGIQLKAVKSKTGPGEHLRNSLWHTGDTSDQVRLLWKDSRNVGWKDKVSYRWFLQHRPQVGYIRVRFYEGSELVADSGVTIDTTMRGGRLGVFCFSQENIIWSNLKYRCNDTIPEDFQEFQTQSFDRLDN
uniprot
proteins
function
FUNCTION: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner. {ECO:0000269|PubMed:20884877, ECO:0000269|PubMed:22034490, ECO:0000269|PubMed:22362893, ECO:0000269|PubMed:22682248, ECO:0000269|PubMed:22745497, ECO:0000269|PubMed:23615612}.
uniprot
proteins
mass_dalton
106366
uniprot
proteins
protein_family
Thrombospondin family
uniprot
proteins
pubmed
10501972
uniprot
proteins
pubmed
20884877
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22034490
uniprot
proteins
pubmed
22362893
uniprot
proteins
pubmed
22682248
uniprot
proteins
pubmed
22745497
uniprot
proteins
pubmed
23615612
uniprot
proteins
sequence_length
963
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:22682248}. Sarcoplasmic reticulum {ECO:0000269|PubMed:22682248}. Secreted {ECO:0000269|PubMed:22682248}. Secreted, extracellular space {ECO:0000269|PubMed:22682248}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:22362893, ECO:0000269|PubMed:22682248}.
uniprot
proteins