IL17F
entrez
112744
canonical
uniprot
Q96PD4
canonical
ensembl
ENSG00000112116
resolver
ensp
ENSP00000337432
resolver
ensp
ENSP00000514702
resolver
enst
ENST00000336123
resolver
enst
ENST00000699946
resolver
genesymbol
IL17F
resolver
hgnc
HGNC:16404
resolver
uniprot
Q6NSI0
resolver
uniprot
Q7Z6P4
resolver
uniprot
Q96PI8
resolver
uniprot
Q9NUE6
resolver
uniprot_entry
IL17F_HUMAN
resolver
uniprot_sec
Q6NSI0
resolver
uniprot_sec
Q7Z6P4
resolver
uniprot_sec
Q96PI8
resolver
uniprot_sec
Q9NUE6
resolver
amino_acid_sequence
MTVKTLHGPAMVKYLLLSILGLAFLSEAAARKIPKVGHTFFQKPESCPPVPGGSMKLDIGIINENQRVSMSRNIESRSTSPWNYTVTWDPNRYPSEVVQAQCRNLGCINAQGKEDISMNSVPIQQETLVVRRKHQGCSVSFQLEKVLVTVGCTCVTPVIHHVQ
uniprot
proteins
disease_involvement
DISEASE: Candidiasis, familial, 6 (CANDF6) [MIM:613956]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. {ECO:0000269|PubMed:21350122}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Effector cytokine of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (PubMed:21350122). IL17A-IL17F signals via IL17RA-IL17RC heterodimeric receptor complex, triggering homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:11574464, PubMed:11591732, PubMed:11591768, PubMed:17911633, PubMed:18684971, PubMed:21350122, PubMed:28827714). IL17A-IL17F is primarily involved in host defense against extracellular bacteria and fungi by inducing neutrophilic inflammation (By similarity). As signature effector cytokine of T-helper 17 cells (Th17), primarily induces neutrophil activation and recruitment at infection and inflammatory sites (By similarity). Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). IL17F homodimer can signal via IL17RC homodimeric receptor complex, triggering downstream activation of TRAF6 and NF-kappa-B signaling pathway (PubMed:32187518). Via IL17RC induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi. Likely via IL17RC, promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression (By similarity). Regulates the composition of intestinal microbiota and immune tolerance by inducing antimicrobial proteins that specifically control the growth of commensal Firmicutes and Bacteroidetes (By similarity). {ECO:0000250|UniProtKB:Q7TNI7, ECO:0000269|PubMed:11574464, ECO:0000269|PubMed:11591732, ECO:0000269|PubMed:11591768, ECO:0000269|PubMed:17911633, ECO:0000269|PubMed:18684971, ECO:0000269|PubMed:21350122, ECO:0000269|PubMed:28827714, ECO:0000269|PubMed:32187518}.
uniprot
proteins
mass_dalton
18045
uniprot
proteins
mutagenesis
MUTAGEN 77; /note="R->A: Significantly decreases the affinity for IL17RA and IL17RC by nearly 5-fold and 200-fold, respectively."; /evidence="ECO:0000269|PubMed:28827714
uniprot
proteins
protein_family
IL-17 family
uniprot
proteins
pubmed
11574464
uniprot
proteins
pubmed
11591732
uniprot
proteins
pubmed
11591768
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17355969
uniprot
proteins
pubmed
17911633
uniprot
proteins
pubmed
18684971
uniprot
proteins
pubmed
19838198
uniprot
proteins
pubmed
21350122
uniprot
proteins
pubmed
28827714
uniprot
proteins
pubmed
32187518
uniprot
proteins
sequence_length
163
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q7TNI7}.
uniprot
proteins