Foxc1
entrez
17300
canonical
uniprot
Q61572
canonical
ensembl
ENSMUSG00000050295
resolver
ensp
ENSMUSP00000052196
resolver
enst
ENSMUST00000062292
resolver
genesymbol
Foxc1
resolver
genesymbol_syn
Fkh1
resolver
genesymbol_syn
Fkhl7
resolver
genesymbol_syn
Freac3
resolver
genesymbol_syn
Mf1
resolver
uniprot
O88409
resolver
uniprot
Q61582
resolver
uniprot
Q9QWR9
resolver
uniprot_entry
FOXC1_MOUSE
resolver
uniprot_sec
O88409
resolver
uniprot_sec
Q61582
resolver
uniprot_sec
Q9QWR9
resolver
amino_acid_sequence
MQARYSVSSPNSLGVVPYLGGEQSYYRAAAAAAGGGYTAMPAPMSVYSHPAHAEQYPGSMARAYGPYTPQPQPKDMVKPPYSYIALITMAIQNAPDKKITLNGIYQFIMDRFPFYRDNKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDPDSYNMFENGSFLRRRRRFKKKDAVKDKEEKGRLHLQEPPPPQAGRQPAPAPPEQAEGSAPGPQPPPVRIQDIKTENGTCPSPPQPLSPAAALGSGSAATVPKIESPDSSSSSLSSGSSPPGSLPSARPLSLDAAEPAPPPQPAPPPHHSQGFSVDNIMTSLRGSPQGSAAELGSGLLASAAASSRAGIAPPLALGAYSPGQSSLYSSPCSQSSSAGSSGGGGGGGGGGGGSSSAAGTGGAATYHCNLQAMSLYAAGERGGHLQGPAGGAGSAAVDDPLPDYSLPPATSSSSSSLSHGGGGQEASHHPASHQGRLTSWYLNQAGGDLGHLASAAAAAAAAGYPGQQQNFHSVREMFESQRIGLNNSPVNGNSSCQMAFPASQSLYRTSGAFVYDCSKF
uniprot
proteins
function
FUNCTION: DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development (PubMed:10395790, PubMed:10479458, PubMed:11562355, PubMed:18187037, PubMed:19668217, PubMed:22493429, PubMed:24590069, PubMed:25808752, PubMed:28223138, PubMed:9106663, PubMed:9635428). Acts either as a transcriptional activator or repressor (PubMed:28223138). Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes (PubMed:25808752). Upon DNA-binding, promotes DNA bending. Acts as a transcriptional coactivator (PubMed:25808752). Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification (PubMed:25808752). Also acts as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells. Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye (By similarity). Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity (PubMed:28223138). Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals. Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion (By similarity). Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression (PubMed:18187037). Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation (By similarity). Essential developmental transcriptional factor required for mesoderm-derived tissues formation, such as the somites, skin, bone and cartilage (PubMed:10395790, PubMed:10479458, PubMed:10704385, PubMed:11562355, PubMed:15196959, PubMed:9106663). Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC) (PubMed:24590069). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner (PubMed:22171010). May function as a tumor suppressor (By similarity). {ECO:0000250|UniProtKB:Q12948, ECO:0000269|PubMed:10395790, ECO:0000269|PubMed:10479458, ECO:0000269|PubMed:10704385, ECO:0000269|PubMed:11562355, ECO:0000269|PubMed:15196959, ECO:0000269|PubMed:18187037, ECO:0000269|PubMed:19668217, ECO:0000269|PubMed:22171010, ECO:0000269|PubMed:22493429, ECO:0000269|PubMed:24590069, ECO:0000269|PubMed:25808752, ECO:0000269|PubMed:28223138, ECO:0000269|PubMed:9106663, ECO:0000269|PubMed:9635428}.
uniprot
proteins
mass_dalton
56940
uniprot
proteins
mutagenesis
MUTAGEN 6..9; /note="SVSS->AVAA: No effect on sumoylation; when associated with A-237; A-243; A-320 and A-521."; /evidence="ECO:0000269|PubMed:22493429"; MUTAGEN 112; /note="F->S: Inhibits interaction with GLI2. Decreased nuclear colocalization with GLI2. No effect on DNA-binding. Decreased Ihh-induced transcriptional activity and transcription coactivator activity with GLI2."; /evidence="ECO:0000269|PubMed:25808752"; MUTAGEN 229; /note="K->R: No effect on protein stability, inhibited sumoylation, increased transcriptional activity; when associated with R-258."; /evidence="ECO:0000269|PubMed:22493429"; MUTAGEN 237; /note="S->A: No effect on sumoylation; when associated with 6-A--A-9; A-243; A-320 and A-521."; /evidence="ECO:0000269|PubMed:22493429"; MUTAGEN 243; /note="S->A: No effect on sumoylation; when associated with 6-A--A-9; A-237; A-320 and A-521."; /evidence="ECO:0000269|PubMed:22493429"; MUTAGEN 258; /note="K->R: No effect on protein stability, inhibited sumoylation, increased transcriptional activity; when associated with R-229."; /evidence="ECO:0000269|PubMed:22493429"; MUTAGEN 320; /note="S->A: No effect on sumoylation; when associated with 6-A--A-9; A-237; A-243 and A-521."; /evidence="ECO:0000269|PubMed:22493429"; MUTAGEN 521; /note="S->A: No effect on sumoylation; when associated with 6-A--A-9; A-237; A-243 and A-320."; /evidence="ECO:0000269|PubMed:22493429
uniprot
proteins
post_translational_modification
PTM: Phosphorylated (PubMed:22493429). Phosphorylated on Ser-274 in response to epidermal growth factor (EGF) in a ERK1/2 MAPK-dependent signaling pathway; phosphorylation contributes to its protein stability and transcriptional regulatory activity (By similarity). {ECO:0000250|UniProtKB:Q12948, ECO:0000269|PubMed:22493429}.; PTM: Sumoylated preferentially with SUMO2 or SUMO3. Desumoylated by SENP2. {ECO:0000269|PubMed:22493429}.; PTM: Ubiquitinated, leading to its proteasomal degradation. {ECO:0000250|UniProtKB:Q12948}.
uniprot
proteins
pubmed
10395790
uniprot
proteins
pubmed
10479458
uniprot
proteins
pubmed
10704385
uniprot
proteins
pubmed
11562355
uniprot
proteins
pubmed
15196959
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16449236
uniprot
proteins
pubmed
18187037
uniprot
proteins
pubmed
19668217
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22171010
uniprot
proteins
pubmed
22493429
uniprot
proteins
pubmed
24590069
uniprot
proteins
pubmed
25808752
uniprot
proteins
pubmed
26565916
uniprot
proteins
pubmed
28223138
uniprot
proteins
pubmed
7689224
uniprot
proteins
pubmed
8375339
uniprot
proteins
pubmed
9106663
uniprot
proteins
pubmed
9635428
uniprot
proteins
pubmed
9767123
uniprot
proteins
sequence_length
553
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11562355, ECO:0000269|PubMed:22493429, ECO:0000269|PubMed:25808752}. Note=Colocalizes with PITX2 in the nucleus at subnuclear chromatin regions. Colocalizes with CBX5 to a heterochromatin-rich region of the nucleus (By similarity). Colocalizes with GLI2 in the nucleus (PubMed:25808752). {ECO:0000250|UniProtKB:Q12948, ECO:0000269|PubMed:25808752}.
uniprot
proteins