PLEKHA3
entrez
65977
canonical
uniprot
Q9HB20
canonical
ensembl
ENSG00000116095
resolver
ensp
ENSP00000234453
resolver
enst
ENST00000234453
resolver
genesymbol
PLEKHA3
resolver
genesymbol_syn
FAPP1
resolver
hgnc
HGNC:14338
resolver
uniprot
Q4ZG69
resolver
uniprot
Q86TQ1
resolver
uniprot
Q9NXT3
resolver
uniprot_entry
PKHA3_HUMAN
resolver
uniprot_sec
Q4ZG69
resolver
uniprot_sec
Q86TQ1
resolver
uniprot_sec
Q9NXT3
resolver
amino_acid_sequence
MEGVLYKWTNYLTGWQPRWFVLDNGILSYYDSQDDVCKGSKGSIKMAVCEIKVHSADNTRMELIIPGEQHFYMKAVNAAERQRWLVALGSSKACLTDTRTKKEKEISETSESLKTKMSELRLYCDLLMQQVHTIQEFVHHDENHSSPSAENMNEASSLLSATCNTFITTLEECVKIANAKFKPEMFQLHHPDPLVSPVSPSPVQMMKRSVSHPGSCSSERSSHSIKEPVSTLHRLSQRRRRTYSDTDSCSDIPLEDPDRPVHCSKNTLNGDLASATIPEESRLMAKKQSESEDTLPSFSS
uniprot
proteins
function
FUNCTION: Plays a role in regulation of vesicular cargo transport from the trans-Golgi network (TGN) to the plasma membrane (PubMed:15107860). Regulates Golgi phosphatidylinositol 4-phosphate (PtdIns(4)P) levels and activates the PtdIns(4)P phosphatase activity of SACM1L when it binds PtdIns(4)P in 'trans' configuration (PubMed:30659099). Binds preferentially to PtdIns(4)P (PubMed:11001876, PubMed:15107860). Negatively regulates APOB secretion from hepatocytes (PubMed:30659099). {ECO:0000269|PubMed:11001876, ECO:0000269|PubMed:15107860, ECO:0000269|PubMed:30659099}.
uniprot
proteins
mass_dalton
33861
uniprot
proteins
pubmed
11001876
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15107860
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20300118
uniprot
proteins
pubmed
21454700
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
30659099
uniprot
proteins
sequence_length
300
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:15107860}; Peripheral membrane protein {ECO:0000269|PubMed:15107860}. Note=Localizes to ER-trans Golgi network (TGN) contacts sites. {ECO:0000269|PubMed:30659099}.
uniprot
proteins