CD5L
entrez
922
canonical
uniprot
O43866
canonical
ensembl
ENSG00000073754
resolver
ensp
ENSP00000357156
resolver
ensp
ENSP00000776343
resolver
ensp
ENSP00000776344
resolver
enst
ENST00000368174
resolver
genesymbol
CD5L
resolver
genesymbol_syn
API6
resolver
hgnc
HGNC:1690
resolver
uniprot
A8K7M5
resolver
uniprot
Q6UX63
resolver
uniprot_entry
CD5L_HUMAN
resolver
uniprot_sec
A8K7M5
resolver
uniprot_sec
Q6UX63
resolver
amino_acid_sequence
MALLFSLILAICTRPGFLASPSGVRLVGGLHRCEGRVEVEQKGQWGTVCDDGWDIKDVAVLCRELGCGAASGTPSGILYEPPAEKEQKVLIQSVSCTGTEDTLAQCEQEEVYDCSHDEDAGASCENPESSFSPVPEGVRLADGPGHCKGRVEVKHQNQWYTVCQTGWSLRAAKVVCRQLGCGRAVLTQKRCNKHAYGRKPIWLSQMSCSGREATLQDCPSGPWGKNTCNHDEDTWVECEDPFDLRLVGGDNLCSGRLEVLHKGVWGSVCDDNWGEKEDQVVCKQLGCGKSLSPSFRDRKCYGPGVGRIWLDNVRCSGEEQSLEQCQHRFWGFHDCTHQEDVAVICSG
uniprot
proteins
function
FUNCTION: Secreted protein that acts as a key regulator of lipid synthesis: mainly expressed by macrophages in lymphoid and inflamed tissues and regulates mechanisms in inflammatory responses, such as infection or atherosclerosis. Able to inhibit lipid droplet size in adipocytes. Following incorporation into mature adipocytes via CD36-mediated endocytosis, associates with cytosolic FASN, inhibiting fatty acid synthase activity and leading to lipolysis, the degradation of triacylglycerols into glycerol and free fatty acids (FFA). CD5L-induced lipolysis occurs with progression of obesity: participates in obesity-associated inflammation following recruitment of inflammatory macrophages into adipose tissues, a cause of insulin resistance and obesity-related metabolic disease. Regulation of intracellular lipids mediated by CD5L has a direct effect on transcription regulation mediated by nuclear receptors ROR-gamma (RORC). Acts as a key regulator of metabolic switch in T-helper Th17 cells. Regulates the expression of pro-inflammatory genes in Th17 cells by altering the lipid content and limiting synthesis of cholesterol ligand of RORC, the master transcription factor of Th17-cell differentiation. CD5L is mainly present in non-pathogenic Th17 cells, where it decreases the content of polyunsaturated fatty acyls (PUFA), affecting two metabolic proteins MSMO1 and CYP51A1, which synthesize ligands of RORC, limiting RORC activity and expression of pro-inflammatory genes. Participates in obesity-associated autoimmunity via its association with IgM, interfering with the binding of IgM to Fcalpha/mu receptor and enhancing the development of long-lived plasma cells that produce high-affinity IgG autoantibodies (By similarity). Also acts as an inhibitor of apoptosis in macrophages: promotes macrophage survival from the apoptotic effects of oxidized lipids in case of atherosclerosis (PubMed:24295828). Involved in early response to microbial infection against various pathogens by acting as a pattern recognition receptor and by promoting autophagy (PubMed:16030018, PubMed:24223991, PubMed:24583716, PubMed:25713983). Promotes recovery from acute kidney injury (AKI) by accumulating on necrotic cell debris within the kidney proximal tubules following AKI and interacting with HAVCR1 expressed on the surface of injured kidney tubular epithelial cells (PubMed:26726878). This enhances HAVCR1-mediated phagocytosis of intraluminal necrotic debris and contributes to kidney tissue repair (PubMed:26726878). Also enhances necrotic debris uptake by kidney macrophages in a HAVCR1-independent manner (By similarity). {ECO:0000250|UniProtKB:Q9QWK4, ECO:0000269|PubMed:16030018, ECO:0000269|PubMed:24223991, ECO:0000269|PubMed:24295828, ECO:0000269|PubMed:24583716, ECO:0000269|PubMed:25713983, ECO:0000269|PubMed:26726878}.
uniprot
proteins
mass_dalton
38088
uniprot
proteins
mutagenesis
MUTAGEN 123; /note="S->A: No effect; when associated with 129-A--A-132."; /evidence="ECO:0000269|PubMed:23236605"; MUTAGEN 129..132; /note="SSFS->AAFA: No effect; when associated with A-123."; /evidence="ECO:0000269|PubMed:23236605
uniprot
proteins
post_translational_modification
PTM: Not N-glycosylated (PubMed:23236605). Probably not O-glycosylated (PubMed:23236605). {ECO:0000269|PubMed:23236605}.
uniprot
proteins
pubmed
11981870
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16030018
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
23236605
uniprot
proteins
pubmed
24223991
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24295828
uniprot
proteins
pubmed
24583716
uniprot
proteins
pubmed
24804991
uniprot
proteins
pubmed
25713983
uniprot
proteins
pubmed
26726878
uniprot
proteins
pubmed
8034987
uniprot
proteins
pubmed
9045627
uniprot
proteins
sequence_length
347
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24223991, ECO:0000269|PubMed:24804991, ECO:0000269|PubMed:26726878}. Cytoplasm {ECO:0000250|UniProtKB:Q9QWK4}. Note=Secreted by macrophages and circulates in the blood (PubMed:24223991, PubMed:24804991). Transported into the cytoplasm via CD36-mediated endocytosis (By similarity). Following acute kidney injury, dissociates from IgM in the blood and is excreted into urine, leading to its accumulation at intraluminal debris in the kidney proximal tubules (PubMed:26726878). {ECO:0000250|UniProtKB:Q9QWK4, ECO:0000269|PubMed:24223991, ECO:0000269|PubMed:24804991, ECO:0000269|PubMed:26726878}.
uniprot
proteins