HRH4
entrez
59340
canonical
uniprot
Q9H3N8
canonical
ensembl
ENSG00000134489
resolver
ensp
ENSP00000256906
resolver
ensp
ENSP00000402526
resolver
genesymbol
HRH4
resolver
genesymbol_syn
GPCR105
resolver
hgnc
HGNC:17383
resolver
uniprot
B0YJ19
resolver
uniprot
B2KJ48
resolver
uniprot
B2KJ49
resolver
uniprot
Q4G0I6
resolver
uniprot
Q9GZQ0
resolver
uniprot_entry
B2KJ49_HUMAN
resolver
uniprot_entry
HRH4_HUMAN
resolver
uniprot_sec
B0YJ19
resolver
uniprot_sec
B2KJ48
resolver
uniprot_sec
Q4G0I6
resolver
uniprot_sec
Q9GZQ0
resolver
amino_acid_sequence
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
uniprot
proteins
function
FUNCTION: G protein-coupled receptor primarily expressed in immune cells such as mast cells, eosinophils, basophils, dendritic cells and neutrophils that plays a key role in immune and inflammatory responses (PubMed:26948974). Mediates chemotaxis of immune cells to sites of inflammation or injury by responding to histamine (PubMed:26948974). Activation by histamine also influences the release of proinflammatory cytokines such as TNF, CCL4, IL6 and IFN-gamma (PubMed:29600327, PubMed:31583075). Ligand binding induces a conformation change that triggers signaling via G(i)/GNAI1 leading to decreased intracellular cAMP levels by inhibiting adenylate cyclase activity (PubMed:39333117). In addition, plays a role in the control of renal reabsorption processes, particularly albumin uptake (By similarity). {ECO:0000250|UniProtKB:Q91ZY2, ECO:0000269|PubMed:12503632, ECO:0000269|PubMed:26948974, ECO:0000269|PubMed:29600327, ECO:0000269|PubMed:31583075, ECO:0000269|PubMed:39333117}.
uniprot
proteins
mass_dalton
44496
uniprot
proteins
mutagenesis
MUTAGEN 344; /note="F->A: More than 30-fold reduced binding affinities of histamine."; /evidence="ECO:0000269|PubMed:39333117"; MUTAGEN 348; /note="W->A: More than 30-fold reduced binding affinities of histamine."; /evidence="ECO:0000269|PubMed:39333117
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10973974
uniprot
proteins
pubmed
11118334
uniprot
proteins
pubmed
11179434
uniprot
proteins
pubmed
11179436
uniprot
proteins
pubmed
11181941
uniprot
proteins
pubmed
12503632
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
18452403
uniprot
proteins
pubmed
26948974
uniprot
proteins
pubmed
29600327
uniprot
proteins
pubmed
31583075
uniprot
proteins
pubmed
34439793
uniprot
proteins
pubmed
39333117
uniprot
proteins
sequence_length
390
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:34439793}; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 20..40; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 53..73; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 88..108; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 132..152; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 173..193; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 305..325; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 342..362; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins