Cplx1
entrez
64832
canonical
uniprot
P63041
canonical
ensembl
ENSRNOG00000090522
resolver
ensp
ENSRNOP00000107898
resolver
enst
ENSRNOT00000123905
resolver
genesymbol
Cplx1
resolver
uniprot
O09057
resolver
uniprot
O09142
resolver
uniprot
Q566D7
resolver
uniprot
Q64276
resolver
uniprot_entry
CPLX1_RAT
resolver
uniprot_sec
O09057
resolver
uniprot_sec
O09142
resolver
uniprot_sec
Q566D7
resolver
uniprot_sec
Q64276
resolver
amino_acid_sequence
MEFVMKQALGGATKDMGKMLGGDEEKDPDAAKKEEERQEALRQAEEERKAKYAKMEAEREVMRQGIRDKYGIKKKEEREAEAQAAMEANSEGSLTRPKKAIPPGCGDEPEEEDESILDTVIKYLPGPLQDMFKK
uniprot
proteins
function
FUNCTION: Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse. Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior. {ECO:0000250|UniProtKB:P63040}.
uniprot
proteins
mass_dalton
15122
uniprot
proteins
protein_family
Complexin/synaphin family
uniprot
proteins
pubmed
10051208
uniprot
proteins
pubmed
10430466
uniprot
proteins
pubmed
10777504
uniprot
proteins
pubmed
11751907
uniprot
proteins
pubmed
11832227
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15911881
uniprot
proteins
pubmed
7553862
uniprot
proteins
pubmed
9753100
uniprot
proteins
sequence_length
134
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:15911881, ECO:0000269|PubMed:7553862, ECO:0000269|PubMed:9753100}. Presynapse {ECO:0000269|PubMed:7553862}. Perikaryon {ECO:0000269|PubMed:7553862}. Note=Enriched at synaptic-releasing sites in mature neurons. {ECO:0000269|PubMed:7553862}.
uniprot
proteins