Smarce1
entrez
303518
canonical
uniprot
Q56A18
canonical
ensembl
ENSRNOG00000010676
resolver
ensembl
ENSRNOG00055033308
resolver
ensembl
ENSRNOG00060021983
resolver
ensembl
ENSRNOG00065026498
resolver
ensp
ENSRNOP00000014230
resolver
ensp
ENSRNOP00000074941
resolver
enst
ENSRNOT00000083233
resolver
genesymbol
Smarce1
resolver
genesymbol_syn
Baf57
resolver
uniprot
A0A0G2K9C1
resolver
uniprot
C0IMX4
resolver
uniprot
C0IMX5
resolver
uniprot
C0IMX6
resolver
uniprot
Q5BJV2
resolver
uniprot_entry
A0A0G2K9C1_RAT
resolver
uniprot_entry
SMCE1_RAT
resolver
uniprot_sec
C0IMX4
resolver
uniprot_sec
C0IMX5
resolver
uniprot_sec
C0IMX6
resolver
uniprot_sec
Q5BJV2
resolver
amino_acid_sequence
MSKRPSYAPPPTPAPATASSGITIPKPPKPPDKPLMPYMRYSRKVWDQVKASNPDLKLWEIGKIIGGMWRDLTDEEKQEYLNEYEAEKIEYNESMKAYHNSPAYLAYINAKSRAEAALEEESRQRQSRMEKGEPYMSIQPAEDPDDYDDGFSMKHTATARFQRNHRLISEILSESVVPDVRSVVTTARMQVLKRQVQSLMVHQRKLEAELLQIEERHQEKKRKFLESTDSFNNELKRLCGLKVEVDMEKIAAEIAQAEEQARKRQEEREKEAAEQAERSQGSIAPEEEQVANKAEEKKDEENIPMETEETHLEDTAENQQNGEEGTSTPEDKESGQEGVDSMEVEGTSDSNTGSESNSATVEEPPTDPVPEDEKKE
uniprot
proteins
function
FUNCTION: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Required for the coactivation of estrogen responsive promoters by SWI/SNF complexes and the SRC/p160 family of histone acetyltransferases (HATs). Also specifically interacts with the CoREST corepressor resulting in repression of neuronal specific gene promoters in non-neuronal cells (By similarity). {ECO:0000250|UniProtKB:O54941, ECO:0000250|UniProtKB:Q969G3}.
uniprot
proteins
mass_dalton
42831
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by TRIP12, leading to its degradation by the proteasome. Ubiquitination is prevented upon interaction between TRIP12 and SMARCC1 (By similarity). {ECO:0000250|UniProtKB:Q969G3}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19245665
uniprot
proteins
pubmed
22215678
uniprot
proteins
sequence_length
376
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
uniprot
proteins