Cops2
entrez
12848
canonical
uniprot
P61202
canonical
ensembl
ENSMUSG00000027206
resolver
ensp
ENSMUSP00000028635
resolver
ensp
ENSMUSP00000106090
resolver
genesymbol
Cops2
resolver
genesymbol_syn
Csn2
resolver
genesymbol_syn
Trip15
resolver
uniprot
O88950
resolver
uniprot
Q15647
resolver
uniprot
Q3V1W6
resolver
uniprot
Q3V3N6
resolver
uniprot
Q8R5B0
resolver
uniprot
Q9CWU1
resolver
uniprot
Q9R249
resolver
uniprot
Q9UNQ5
resolver
uniprot_entry
CSN2_MOUSE
resolver
uniprot_entry
Q3V3N6_MOUSE
resolver
uniprot_sec
O88950
resolver
uniprot_sec
Q15647
resolver
uniprot_sec
Q3V1W6
resolver
uniprot_sec
Q8R5B0
resolver
uniprot_sec
Q9CWU1
resolver
uniprot_sec
Q9R249
resolver
uniprot_sec
Q9UNQ5
resolver
amino_acid_sequence
MSDMEDDFMCDDEEDYDLEYSEDSNSEPNVDLENQYYNSKALKEDDPKAALSSFQKVLELEGEKGEWGFKALKQMIKINFKLTNFPEMMNRYKQLLTYIRSAVTRNYSEKSINSILDYISTSKQMDLLQEFYETTLEALKDAKNDRLWFKTNTKLGKLYLEREEYGKLQKILRQLHQSCQTDDGEDDLKKGTQLLEIYALEIQMYTAQKNNKKLKALYEQSLHIKSAIPHPLIMGVIRECGGKMHLREGEFEKAHTDFFEAFKNYDESGSPRRTTCLKYLVLANMLMKSGINPFDSQEAKPYKNDPEILAMTNLVSAYQNNDITEFEKILKTNHSNIMDDPFIREHIEELLRNIRTQVLIKLIKPYTRIHIPFISKELNIDVADVESLLVQCILDNTIHGRIDQVNQLLELDHQKRGGARYTALDKWTNQLNSLNQAVVSKLA
uniprot
proteins
function
FUNCTION: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1. {ECO:0000269|PubMed:11967155, ECO:0000269|PubMed:12522100, ECO:0000269|PubMed:12972599}.
uniprot
proteins
mass_dalton
51597
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CK2 and PKD kinases. {ECO:0000250}.
uniprot
proteins
protein_family
CSN2 family
uniprot
proteins
pubmed
10087198
uniprot
proteins
pubmed
11967155
uniprot
proteins
pubmed
12522100
uniprot
proteins
pubmed
12972599
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9707402
uniprot
proteins
sequence_length
443
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10087198}. Nucleus {ECO:0000269|PubMed:10087198}.
uniprot
proteins