Dixdc1
entrez
330938
canonical
uniprot
Q80Y83
canonical
ensembl
ENSMUSG00000032064
resolver
ensp
ENSMUSP00000034566
resolver
ensp
ENSMUSP00000112431
resolver
ensp
ENSMUSP00000113089
resolver
ensp
ENSMUSP00000113934
resolver
ensp
ENSMUSP00000163289
resolver
ensp
ENSMUSP00000163291
resolver
ensp
ENSMUSP00000163292
resolver
genesymbol
Dixdc1
resolver
genesymbol_syn
Ccd1
resolver
genesymbol_syn
Kiaa1735
resolver
uniprot
Q3TPF4
resolver
uniprot
Q3UQ90
resolver
uniprot
Q5DPZ2
resolver
uniprot
Q5DPZ3
resolver
uniprot
Q5DPZ4
resolver
uniprot
Q5DPZ6
resolver
uniprot
Q6ZPJ2
resolver
uniprot
Q8C467
resolver
uniprot
Q8R1C1
resolver
uniprot_entry
DIXC1_MOUSE
resolver
uniprot_sec
Q3TPF4
resolver
uniprot_sec
Q3UQ90
resolver
uniprot_sec
Q5DPZ2
resolver
uniprot_sec
Q5DPZ3
resolver
uniprot_sec
Q5DPZ4
resolver
uniprot_sec
Q5DPZ6
resolver
uniprot_sec
Q6ZPJ2
resolver
uniprot_sec
Q8C467
resolver
uniprot_sec
Q8R1C1
resolver
amino_acid_sequence
MLACLTRGNLLDVLQEGFNEQQLQAYVAWVNAQLKKRPSVKPVQDLRQDLRDGVILAYLIEIVGQLALDSDASVDERTDFFLLHSPFKAAGEKLTGVQLSPSNQQEMKSNVERVLQFVASKKIRMHQTSAKDIVEGNLKSIMRLVLALAAHFKPGSSRTVSQGRDSKAPVQSHQPHCATAVAQGAAAALADVCHDVSRSGRDVFRYRQRNASVDGEIENPYWSVRALVQQYEGQQKSPSESSCSSLTSPSPIHSAKSESIITQAEEKADFVIIPSEGIENRTDEPDSPSSRDWRPGSRGTYLEATWEEQLLEQQEHLEKEMEEAKKMISGLQALLLNGSLPEDEQERPVALCEPGVNPEEQLIIIRSRLDQSVEENQDLKKELLKCKQEARNLQGIKDALQQRLTQQDTSVLQLKQELLRANMDKDELHNQNVDLQRKLEERNRLLGEYKKELGQKDRLFQQQQAKLEEALRKLSDASYQQVDLERELEQKDVLLAHCMKGETDEVTNYNSHSSQRNGFVLPVAGRGATTVTHRGPQTSDLQLVRDALRSLRNSFSGHDPQHHTIDSLEQGISSLMERLHVVETQKKQERKVGGRSPRNQASSEYRASWPPNSTLPHSQSSPAVSSTCTKVLYFTDRSLTPFMVNIPKRLGEVTLKDFKAAIDREGNHRYHFKALDPEFGTVKEEVFHDDDAIPGWEGKIVAWVEEDHREN
uniprot
proteins
function
FUNCTION: Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2. {ECO:0000269|PubMed:15262978, ECO:0000269|PubMed:15857680}.
uniprot
proteins
mass_dalton
80215
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine and serine residues. {ECO:0000250|UniProtKB:Q155Q3}.; PTM: Polyubiquitinated, leading to its proteasomal degradation. WNT3A signaling increases DIXDC1 protein levels by inhibiting its ubiquitination and subsequent degradation. {ECO:0000250|UniProtKB:Q155Q3}.
uniprot
proteins
protein_family
DIXDC1 family
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15262978
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15857680
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16378754
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
711
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q155Q3}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:Q155Q3}. Cytoplasm {ECO:0000250|UniProtKB:Q155Q3}. Note=Colocalizes with gamma-tubulin at the centrosome, both during interphase and mitosis. Associated with actin stress fiber at the filament ends. {ECO:0000250|UniProtKB:Q155Q3}.
uniprot
proteins