Relb
entrez
19698
canonical
uniprot
Q04863
canonical
ensembl
ENSMUSG00000002983
resolver
ensp
ENSMUSP00000050166
resolver
ensp
ENSMUSP00000092355
resolver
enst
ENSMUST00000049912
resolver
enst
ENSMUST00000094762
resolver
genesymbol
Relb
resolver
uniprot
F6VX85
resolver
uniprot
Q8K220
resolver
uniprot
Q8VE46
resolver
uniprot_entry
F6VX85_MOUSE
resolver
uniprot_entry
Q8K220_MOUSE
resolver
uniprot_entry
RELB_MOUSE
resolver
uniprot_sec
Q8VE46
resolver
amino_acid_sequence
MPSRRAARESAPELGALGSSDLSSLSLTVSRTTDELEIIDEYIKENGFGLDGTQLSEMPRLVPRGPASLSSVTLGPAAPPPPATPSWSCTLGRLVSPGPCPRPYLVITEQPKQRGMRFRYECEGRSAGSILGESSTEASKTLPAIELRDCGGLREVEVTACLVWKDWPHRVHPHSLVGKDCTDGVCRVRLRPHVSPRHSFNNLGIQCVRKKEIEAAIERKIQLGIDPYNAGSLKNHQEVDMNVVRICFQASYRDQQGHLHRMDPILSEPVYDKKSTNTSELRICRINKESGPCTGGEELYLLCDKVQKEDISVVFSTASWEGRADFSQADVHRQIAIVFKTPPYEDLEISEPVTVNVFLQRLTDGVCSEPLPFTYLPRDHDSYGVDKKRKRGLPDVLGELSSSDPHGIESKRRKKKPVFLDHFLPGHSSGLFLPPSALQPADSDFFPASISLPGLEPPGGPDLLDDGFAYDPSAPTLFTMLDLLPPAPPLASAVVGSGGAGATVVESSGPEPLSLDSFAAPGPGDVGTASLVGSNMFPNQYREAAFGGGLLSPGPEAT
uniprot
proteins
function
FUNCTION: NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49 (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer in a CRY1/CRY2 independent manner. Increased repression of the heterodimer is seen in the presence of NFKB2/p52. Is required for both T and B lymphocyte maturation and function (By similarity). {ECO:0000250|UniProtKB:Q01201, ECO:0000269|PubMed:22565310, ECO:0000269|PubMed:22894897}.
uniprot
proteins
mass_dalton
60305
uniprot
proteins
mutagenesis
MUTAGEN 368; /note="S->A,E: Strongly reduces transcriptional activity and interaction with NFKB1/p50 and NFKB2/p52."; /evidence="ECO:0000269|PubMed:12874295
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at 'Thr-103' and 'Ser-573' is followed by proteasomal degradation. {ECO:0000269|PubMed:11781828}.
uniprot
proteins
pubmed
11781828
uniprot
proteins
pubmed
11931770
uniprot
proteins
pubmed
12874295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16154093
uniprot
proteins
pubmed
1732739
uniprot
proteins
pubmed
17869269
uniprot
proteins
pubmed
22565310
uniprot
proteins
pubmed
22894897
uniprot
proteins
pubmed
7845467
uniprot
proteins
pubmed
8441398
uniprot
proteins
sequence_length
558
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Colocalizes with NEK6 in the centrosome. {ECO:0000250}.
uniprot
proteins