Gpr132
entrez
56696
canonical
uniprot
Q9Z282
canonical
ensembl
ENSMUSG00000021298
resolver
ensp
ENSMUSP00000021729
resolver
enst
ENSMUST00000021729
resolver
genesymbol
Gpr132
resolver
genesymbol_syn
G2a
resolver
uniprot
Q0VBS4
resolver
uniprot
Q3U5A4
resolver
uniprot_entry
GP132_MOUSE
resolver
uniprot_sec
Q0VBS4
resolver
uniprot_sec
Q3U5A4
resolver
amino_acid_sequence
MRSEPTNAAGNTTLGVTSVLQSTSVPSSETCHVSYEESRVVLVVVYSAVCLLGLPANCLTAWLTLLQVLQRNVLAVYLFCLSLCELLYISTVPLWIIYIQNQHKWNLGPQACKVTAYIFFCNIYISILLLCCISCDRYMAVVYALESRGHRHQRTAVTISACVILLVGLVNYPVFDMKVEKSFCFEPLRMNSKIAGYHYLRFTFGFAIPLGILAFTNHQIFRSIKLSDSLSAAQKNKVKRSAIAVVTIFLVCFAPYHVVLLVKAASFSFYQGDMDAVCAFESRLYTVSMVFLCLSTVNSVADPIIYVLGTDHSRQEVSRIHTGWKKWSTKTYVTCSKDSEETHLPTELSNTYTFPNPAHPPGSQPAKLGLLCSPERLPEELC
uniprot
proteins
function
FUNCTION: May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensing activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:15728718}.
uniprot
proteins
mass_dalton
42653
uniprot
proteins
mutagenesis
MUTAGEN 137; /note="R->A: Enhanced surface expression and a lower localization to endosomal vesicles."; /evidence="ECO:0000269|PubMed:15728718
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12482833
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15728718
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
9770487
uniprot
proteins
sequence_length
382
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:15728718}; Multi-pass membrane protein {ECO:0000305|PubMed:15728718}. Note=Internalized and accumulated in endosomal compartments. LPC triggers the relocalization from the endosomal compartment to the cell surface.
uniprot
proteins
transmembrane_region
TRANSMEM 43..65; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 77..99; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 114..135; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 156..175; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 199..221; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 242..261; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 287..309; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins