Lamp3
entrez
303801
canonical
uniprot
Q5XI99
canonical
ensembl
ENSRNOG00000022792
resolver
ensp
ENSRNOP00000038456
resolver
ensp
ENSRNOP00000087228
resolver
enst
ENSRNOT00000034498
resolver
genesymbol
Lamp3
resolver
uniprot_entry
LAMP3_RAT
resolver
amino_acid_sequence
MPGQTSAVAVLLCLAVILHGYQIREKEFPEARGYLQYTATTTEQITAKPPLPLTNQTSHATLASRSKDDYIQTAAETSTFEDTAHITMKTAIPVTTKSLLPISSTSYTFVRTNNSHMTASSTEDTIGSGSITHLPFPTTRASLAAVNHITGRSTQLGGQTTLPKALFTPSHESTTTQRPTLSTIVSELTPTGKDRSTTSSVPLVPRPTFVTWSSPAKIGTYEVLNGSRLCIKAEMGIALIVQEKGLDSATQRHFNIDPSLTHASGKCGSQNSNLFLNFQGGSVNVTFTKEENLYYVSEVGAYLTISNTEKTYQGKSTMMMFETVVGHSFKCVSEQSIQLSAQLQMKTMNIHLQAFDFEGDSFGIVDECLSDYTVVLPVVGIIVVVLCVVGLGIYKIRQRRQSSAYQRI
uniprot
proteins
function
FUNCTION: Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR) that contributes to protein degradation and cell survival during proteasomal dysfunction. Plays a role in the process of fusion of the lysosome with the autophagosome, thereby modulating the autophagic process. Promotes hepatocellular lipogenesis through activation of the PI3K/Akt pathway. May also play a role in dendritic cell function and in adaptive immunity. {ECO:0000250|UniProtKB:Q9UQV4}.
uniprot
proteins
mass_dalton
44388
uniprot
proteins
protein_family
LAMP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
408
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell surface {ECO:0000250|UniProtKB:Q9UQV4}. Lysosome membrane {ECO:0000250|UniProtKB:Q9UQV4}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9UQV4}; Single-pass type I membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:Q9UQV4}; Single-pass type I membrane protein {ECO:0000255}. Note=During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3. Detected on lysosomes in mature dendritic cells. {ECO:0000250|UniProtKB:Q9UQV4}.
uniprot
proteins
transmembrane_region
TRANSMEM 374..394; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00740
uniprot
proteins