Prima1
entrez
170952
canonical
uniprot
Q810F0
canonical
ensembl
ENSMUSG00000041669
resolver
ensp
ENSMUSP00000074017
resolver
ensp
ENSMUSP00000314761
resolver
enst
ENSMUST00000074416
resolver
genesymbol
Prima1
resolver
uniprot
F8VQJ2
resolver
uniprot
Q3USW1
resolver
uniprot
Q3V3K1
resolver
uniprot
Q8VHC4
resolver
uniprot_entry
F8VQJ2_MOUSE
resolver
uniprot_entry
PRIMA_MOUSE
resolver
uniprot_entry
Q3USW1_MOUSE
resolver
uniprot_entry
Q3V3K1_MOUSE
resolver
uniprot_sec
Q8VHC4
resolver
amino_acid_sequence
MLLRDLVPRHGCCWPSLLLHCALHPLWGLVQVTHAEPQKSCSKVTDSCQHICQCRPPPPLPPPPPPPPPPRLLSAPAPNSTSCPAEDSWWSGLVIIVAVVCASLVFLTVLVIICYKAIKRKPLRKDENGTSVAEYPMSSSQSHKGVDVNAAVV
uniprot
proteins
function
FUNCTION: Required to anchor acetylcholinesterase (ACHE) to the basal lamina of the neuromuscular junction and to the membrane of neuronal synapses in brain. Also able to organize ACHE into tetramers. {ECO:0000269|PubMed:11804574}.
uniprot
proteins
mass_dalton
16564
uniprot
proteins
mutagenesis
MUTAGEN 109..121; /note="VLVIICYKAIKRK->GIAIICLKAISDM: Decrease in ACHE tetramer recruitment to membrane rafts."; /evidence="ECO:0000269|PubMed:20147288"; MUTAGEN 114; /note="C->A: Does not abolish the localization of ACHE."; /evidence="ECO:0000269|PubMed:11804574, ECO:0000269|PubMed:20147288"; MUTAGEN 114; /note="C->S: No effect on ACHE tetramer recruitment to membrane rafts."; /evidence="ECO:0000269|PubMed:11804574, ECO:0000269|PubMed:20147288"; MUTAGEN 131; /note="S->A: No effect on ACHE tetramer recruitment to membrane rafts; when associated with 138-A--A-142."; MUTAGEN 138..142; /note="SSSQS->AAAQA: No effect on ACHE tetramer recruitment to membrane rafts; when associated with A-131."; /evidence="ECO:0000269|PubMed:20147288
uniprot
proteins
pubmed
11804574
uniprot
proteins
pubmed
14622217
uniprot
proteins
pubmed
20147288
uniprot
proteins
sequence_length
153
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Cell junction. Synapse. Note=In the brain, PRIMA linked to ACHE is found in membrane rafts.
uniprot
proteins
transmembrane_region
TRANSMEM 93..113; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins