Cbfa2t3
entrez
12398
canonical
uniprot
O54972
canonical
ensembl
ENSMUSG00000006362
resolver
ensp
ENSMUSP00000006525
resolver
ensp
ENSMUSP00000065728
resolver
ensp
ENSMUSP00000118997
resolver
enst
ENSMUST00000064674
resolver
enst
ENSMUST00000127984
resolver
genesymbol
Cbfa2t3
resolver
genesymbol_syn
Cbfa2t3h
resolver
genesymbol_syn
Mtgr2
resolver
uniprot
B7ZP57
resolver
uniprot
E9QM80
resolver
uniprot
F6W1C3
resolver
uniprot
Q7TND6
resolver
uniprot
Q8BZS0
resolver
uniprot_entry
B7ZP57_MOUSE
resolver
uniprot_entry
E9QM80_MOUSE
resolver
uniprot_entry
F6W1C3_MOUSE
resolver
uniprot_entry
MTG16_MOUSE
resolver
uniprot_sec
Q7TND6
resolver
uniprot_sec
Q8BZS0
resolver
amino_acid_sequence
MSQASTTTLESGALLSGPRGLQYGSPAHRKEKAAAMPDSPAEVKTQPRSTPPSMPPPPPTSSQGATRPPSFTPHTHGEDGPATSLPHGRFHGCLKWSMVCLLMNGSSHSPTAIHGAPSTPNGFSNGPATSSTASLSTQHLPPACGARQLSKLKRFLTTLQQFGSDISPEIGERVRTLVLGLVNSTLTIEEFHAKLQEATNFPLRPFVIPFLKANLPLLQRELLHCARLAKQTPAQYLAQHEQLLLDASATSPVDSSELLLEVNENGKRRTPDRTKENGSDRDPLHPDHLSKRSCTLSPAQRCSPSNGLPHPTPPPPPHYRLEDMAMAHHFRDSYRHPDPRELRERHRPLAIPGSRQEEVIDHRLTEREWAEEWKHLNSLLNCIMDMVEKTRRSLTVLRRCQEADREELNHWIRCYSDSEEGKKGPTPISARSLNSCSGPEGSQLDVHRDFTPRTLSGYMPEEIWRKAEEAVNEVKRQAMSELQKAVSDAERKAHELITTERAKMERALAEAKRQASEDALTVINQQEDSSESCWNCGRKASETCSGCNAARYCGSFCQHKDWEKHHHVCGQSLQGPAAAVADPLPGQPDATASPSEAGSAGPSRPCSPGPPGPLDAAVPR
uniprot
proteins
function
FUNCTION: Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway. Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (By similarity). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (PubMed:16407974). Plays a role in granulocyte differentiation (PubMed:15231665). {ECO:0000250|UniProtKB:O75081, ECO:0000269|PubMed:11533236, ECO:0000269|PubMed:15231665, ECO:0000269|PubMed:16407974}.
uniprot
proteins
mass_dalton
68032
uniprot
proteins
protein_family
CBFA2T family
uniprot
proteins
pubmed
10022820
uniprot
proteins
pubmed
11533236
uniprot
proteins
pubmed
15231665
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16407974
uniprot
proteins
pubmed
17533052
uniprot
proteins
sequence_length
620
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:10022820}. Nucleus, nucleoplasm {ECO:0000269|PubMed:10022820}. Golgi apparatus membrane {ECO:0000250}.
uniprot
proteins