SNCAIP
entrez
9627
canonical
uniprot
Q9Y6H5
canonical
ensembl
ENSG00000064692
resolver
ensp
ENSP00000261367
resolver
ensp
ENSP00000261368
resolver
ensp
ENSP00000378849
resolver
ensp
ENSP00000378852
resolver
ensp
ENSP00000423360
resolver
ensp
ENSP00000441681
resolver
ensp
ENSP00000563334
resolver
ensp
ENSP00000563335
resolver
ensp
ENSP00000563337
resolver
ensp
ENSP00000563341
resolver
ensp
ENSP00000624377
resolver
ensp
ENSP00000624378
resolver
ensp
ENSP00000624379
resolver
ensp
ENSP00000624380
resolver
ensp
ENSP00000624381
resolver
ensp
ENSP00000624383
resolver
ensp
ENSP00000624385
resolver
ensp
ENSP00000624386
resolver
ensp
ENSP00000718754
resolver
ensp
ENSP00000732721
resolver
ensp
ENSP00000732722
resolver
ensp
ENSP00000732723
resolver
ensp
ENSP00000732725
resolver
enst
ENST00000395466
resolver
enst
ENST00000512146
resolver
enst
ENST00000542191
resolver
genesymbol
SNCAIP
resolver
hgnc
HGNC:11139
resolver
uniprot
B7Z616
resolver
uniprot
B7Z995
resolver
uniprot
D3DSZ1
resolver
uniprot
D6RHZ0
resolver
uniprot
F6T5L4
resolver
uniprot
F6V7P9
resolver
uniprot
Q05BS1
resolver
uniprot
Q1PSC2
resolver
uniprot
Q49AC6
resolver
uniprot
Q504U9
resolver
uniprot
Q6L981
resolver
uniprot
Q6L983
resolver
uniprot
Q6L984
resolver
uniprot
Q6L985
resolver
uniprot
Q6L986
resolver
uniprot
Q9HC59
resolver
uniprot_entry
B7Z616_HUMAN
resolver
uniprot_entry
B7Z995_HUMAN
resolver
uniprot_entry
F6T5L4_HUMAN
resolver
uniprot_entry
F6V7P9_HUMAN
resolver
uniprot_entry
Q6L981_HUMAN
resolver
uniprot_entry
Q6L983_HUMAN
resolver
uniprot_entry
SNCAP_HUMAN
resolver
uniprot_sec
D3DSZ1
resolver
uniprot_sec
D6RHZ0
resolver
uniprot_sec
Q05BS1
resolver
uniprot_sec
Q1PSC2
resolver
uniprot_sec
Q49AC6
resolver
uniprot_sec
Q504U9
resolver
uniprot_sec
Q6L984
resolver
uniprot_sec
Q6L985
resolver
uniprot_sec
Q6L986
resolver
uniprot_sec
Q9HC59
resolver
amino_acid_sequence
MEAPEYLDLDEIDFSDDISYSVTSLKTIPELCRRCDTQNEDRSVSSSSWNCGISTLITNTQKPTGIADVYSKFRPVKRVSPLKHQPETLENNESDDQKNQKVVEYQKGGESDLGPQPQELGPGDGVGGPPGKSSEPSTSLGELEHYDLDMDEILDVPYIKSSQQLASFTKVTSEKRILGLCTTINGLSGKACSTGSSESSSSNMAPFCVLSPVKSPHLRKASAVIHDQHKLSTEETEISPPLVKCGSAYEPENQSKDFLNKTFSDPHGRKVEKTTPDCQLRAFHLQSSAAESKPEEQVSGLNRTSSQGPEERSEYLKKVKSILNIVKEGQISLLPHLAADNLDKIHDENGNNLLHIAASQGHAECLQHLTSLMGEDCLNERNTEKLTPAGLAIKNGQLECVRWMVSETEAIAELSCSKDFPSLIHYAGCYGQEKILLWLLQFMQEQGISLDEVDQDGNSAVHVASQHGYLGCIQTLVEYGANVTMQNHAGEKPSQSAERQGHTLCSRYLVVVETCMSLASQVVKLTKQLKEQTVERVTLQNQLQQFLEAQKSEGKSLPSSPSSPSSPASRKSQWKSPDADDDSVAKSKPGVQEGIQVLGSLSASSRARPKAKDEDSDKILRQLLGKEISENVCTQEKLSLEFQDAQASSRNSKKIPLEKRELKLARLRQLMQRSLSESDTDSNNSEDPKTTPVRKADRPRPQPIVESVESMDSAESLHLMIKKHTLASGGRRFPFSIKASKSLDGHSPSPTSESSEPDLESQYPGSGSIPPNQPSGDPQQPSPDSTAAQKVATSPKSALKSPSSKRRTSQNLKLRVTFEEPVVQMEQPSLELNGEKDKDKGRTLQRTSTSNESGDQLKRPFGAFRSIMETLSGNQNNNNNYQAANQLKTSTLPLTSLGRKTDAKGNPASSASKGKNKAA
uniprot
proteins
disease_involvement
DISEASE: Parkinson disease (PARK) [MIM:168600]: A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. Additional features are characteristic postural abnormalities, dysautonomia, dystonic cramps, and dementia. The pathology of Parkinson disease involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. The disease is progressive and usually manifests after the age of 50 years, although early-onset cases (before 50 years) are known. The majority of the cases are sporadic suggesting a multifactorial etiology based on environmental and genetic factors. However, some patients present with a positive family history for the disease. Familial forms of the disease usually begin at earlier ages and are associated with atypical clinical features. {ECO:0000269|PubMed:12761037}. Note=Disease susceptibility may be associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Isoform 2 inhibits the ubiquitin ligase activity of SIAH1 and inhibits proteasomal degradation of target proteins. Isoform 2 inhibits autoubiquitination and proteasomal degradation of SIAH1, and thereby increases cellular levels of SIAH. Isoform 2 modulates SNCA monoubiquitination by SIAH1. {ECO:0000269|PubMed:16595633, ECO:0000269|PubMed:19224863}.
uniprot
proteins
mass_dalton
100409
uniprot
proteins
mutagenesis
MUTAGEN 79; /note="V->N: Decreases interaction with SIAH1 and formation of cytoplasmic inclusion bodies; when associated with N-81."; /evidence="ECO:0000269|PubMed:15064394"; MUTAGEN 81; /note="P->N: Decreases interaction with SIAH1 and formation of cytoplasmic inclusion bodies; when associated with N-79."; /evidence="ECO:0000269|PubMed:15064394
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; mediated by SIAH1, SIAH2 or RNF19A and leading to its subsequent proteasomal degradation. In the absence of proteasomal degradation, ubiquitinated SNCAIP accumulates in cytoplasmic inclusion bodies. Isoform 2 is subject to limited ubiquitination that does not lead to proteasomal degradation. {ECO:0000269|PubMed:11590439, ECO:0000269|PubMed:12750386, ECO:0000269|PubMed:15064394}.
uniprot
proteins
pubmed
10319874
uniprot
proteins
pubmed
10967135
uniprot
proteins
pubmed
11590439
uniprot
proteins
pubmed
12750386
uniprot
proteins
pubmed
12761037
uniprot
proteins
pubmed
14506261
uniprot
proteins
pubmed
15064394
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16595633
uniprot
proteins
pubmed
18366718
uniprot
proteins
pubmed
19224863
uniprot
proteins
pubmed
19762560
uniprot
proteins
sequence_length
919
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10319874, ECO:0000269|PubMed:15064394, ECO:0000269|PubMed:16595633, ECO:0000269|PubMed:19762560}. Note=Detected in cytoplasmic inclusion bodies, together with SNCA.
uniprot
proteins