CD37
entrez
951
canonical
uniprot
P11049
canonical
ensembl
ENSG00000104894
resolver
ensp
ENSP00000325708
resolver
ensp
ENSP00000413151
resolver
ensp
ENSP00000470683
resolver
ensp
ENSP00000788341
resolver
genesymbol
CD37
resolver
genesymbol_syn
TSPAN26
resolver
hgnc
HGNC:1666
resolver
uniprot
B4DVC1
resolver
uniprot
Q3KPF9
resolver
uniprot_entry
CD37_HUMAN
resolver
uniprot_sec
B4DVC1
resolver
uniprot_sec
Q3KPF9
resolver
amino_acid_sequence
MSAQESCLSLIKYFLFVFNLFFFVLGSLIFCFGIWILIDKTSFVSFVGLAFVPLQIWSKVLAISGIFTMGIALLGCVGALKELRCLLGLYFGMLLLLFATQITLGILISTQRAQLERSLRDVVEKTIQKYGTNPEETAAEESWDYVQFQLRCCGWHYPQDWFQVLILRGNGSEAHRVPCSCYNLSATNDSTILDKVILPQLSRLGHLARSRHSADICAVPAESHIYREGCAQGLQKWLHNNLISIVGICLGVGLLELGFMTLSIFLCRNLDHVYNRLARYR
uniprot
proteins
function
FUNCTION: Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking (PubMed:22624718). Upon ligand binding, two signaling pathways are activated, one acting through phosphorylation by LYN leading to cell death or a survival pathway with activation of GSK3B (PubMed:22624718). Plays an essential role essential for clustering of integrin ITGA4/ITGB1 and promotes its mobility in the plasma membrane of B-cells. In turn, participates in ITGA4/ITGB1 integrin-mediated antiapoptotic signaling through AKT (By similarity). Also plays a role in the migration of dendritic cells and neutrophils to draining lymph nodes, as well as in their integrin-mediated adhesion (By similarity). Negatively regulates IL-6 responses through direct interaction with SOCS3 thereby preventing constitutive IL-6 signaling (PubMed:26784544). Alternatively, inhibition of IL-6 signaling can also occur via interaction and stabilization of DECTIN1/CLEC7A at the cell membrane to inhibit its ability to promote the production of IL-6 (PubMed:17182550). {ECO:0000250|UniProtKB:Q61451, ECO:0000269|PubMed:17182550, ECO:0000269|PubMed:22624718, ECO:0000269|PubMed:26784544}.
uniprot
proteins
mass_dalton
31703
uniprot
proteins
mutagenesis
MUTAGEN 13; /note="Y->F: Complete loss of surface expression."; /evidence="ECO:0000269|PubMed:22624718"; MUTAGEN 274; /note="Y->F: No loss of surface expression but significant increase of CD37-mediated cell death."; /evidence="ECO:0000269|PubMed:22624718
uniprot
proteins
post_translational_modification
PTM: Tyrosine phosphorylated; leading to activation of downstream signaling pathways. {ECO:0000269|PubMed:22624718}.
uniprot
proteins
protein_family
Tetraspanin (TM4SF) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17182550
uniprot
proteins
pubmed
21930792
uniprot
proteins
pubmed
22624718
uniprot
proteins
pubmed
2388030
uniprot
proteins
pubmed
2466944
uniprot
proteins
pubmed
26784544
uniprot
proteins
sequence_length
281
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17182550, ECO:0000269|PubMed:22624718, ECO:0000269|PubMed:26784544}; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 18..38; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 60..74; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 86..111; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 242..266; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins