Nhlrc1
entrez
105193
canonical
uniprot
Q8BR37
canonical
ensembl
ENSMUSG00000044231
resolver
ensp
ENSMUSP00000054990
resolver
enst
ENSMUST00000052747
resolver
genesymbol
Nhlrc1
resolver
genesymbol_syn
Epm2b
resolver
uniprot
Q0VF71
resolver
uniprot_entry
NHLC1_MOUSE
resolver
uniprot_entry
Q0VF71_MOUSE
resolver
amino_acid_sequence
MGEEATAVAAAGVRPELVREAEVSLLECKVCFERFGHWQQRRPRNLPCGHVVCLACVAALAHPRTLGLECPFCRRACRACDTSDCLPVLHLLELLGSTLHASPAALSAAPFAPGTLTCYHAFGGWGTLVNPTGLALCPKTGRVVVVHDGKRRVKIFDSGGGGAHQFGEKGDAAHDVKYPLDVAVTNDCHVVVTDAGDCSLKVFDFFGQIKLVVGKQFSLPWGVEITPHNGVLVTDAEAGTLHLLEADFPEGVLRRIERLQAHLCSPRGLAVSWLTGAIAVLEHPCAFGRTGCNNTRVKVFNSTMQLIGQVDSFGLNLLFPSKVTASAVTFDHQGNVIVADTSGPAIVCLGKPEEFPALKPIITHGLSRPVALAFTKENSLLVLDTASHSIKVFKVMEGNGG
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway. {ECO:0000269|PubMed:19036738, ECO:0000269|PubMed:21077101, ECO:0000269|PubMed:22186026, ECO:0000269|PubMed:22669944}.
uniprot
proteins
mass_dalton
42690
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
12958597
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19036738
uniprot
proteins
pubmed
21077101
uniprot
proteins
pubmed
22186026
uniprot
proteins
pubmed
22669944
uniprot
proteins
sequence_length
401
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250}. Nucleus {ECO:0000250}. Note=Localizes at the endoplasmic reticulum and, to a lesser extent, in the nucleus. {ECO:0000250}.
uniprot
proteins