Pacsin3
entrez
80708
canonical
uniprot
Q99JB8
canonical
ensembl
ENSMUSG00000027257
resolver
ensp
ENSMUSP00000028694
resolver
ensp
ENSMUSP00000054391
resolver
ensp
ENSMUSP00000106981
resolver
ensp
ENSMUSP00000129175
resolver
ensp
ENSMUSP00000173482
resolver
ensp
ENSMUSP00000173483
resolver
ensp
ENSMUSP00000173500
resolver
ensp
ENSMUSP00000173520
resolver
ensp
ENSMUSP00000358556
resolver
enst
ENSMUST00000028694
resolver
enst
ENSMUST00000059566
resolver
enst
ENSMUST00000111349
resolver
enst
ENSMUST00000168916
resolver
genesymbol
Pacsin3
resolver
uniprot
Q543N7
resolver
uniprot
Q9EQP9
resolver
uniprot_entry
PACN3_MOUSE
resolver
uniprot_entry
Q543N7_MOUSE
resolver
uniprot_sec
Q9EQP9
resolver
amino_acid_sequence
MAPEEDAGGEVLGGSFWEAGNYRRTVQRVEDGHRLCGDLVSCFQERARIEKAYAQQLADWARKWRGAVEKGPQYGTLEKAWHAFFTAAERLSELHLEVREKLHGPDSERVRTWQRGAFHRPVLGGFRESRAAEDGFRKAQKPWLKRLKEVEASKKSYHTARKDEKTAQTRESHAKADSSMSQEQLRKLQERVGRCTKEAEKMKTQYEQTLAELNRYTPRYMEDMEQAFESCQAAERQRLLFFKDVLLTLHQHLDLSSSDKFHELHRDLQQSIEAASDEEDLRWWRSTHGPGMAMNWPQFEEWSLDTQRAISRKEKGGRSPDEVTLTSIVPTRDGTAPPPQSPSSPGSGQDEDWSDEESPRKVATGVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVECVGA
uniprot
proteins
function
FUNCTION: Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity. {ECO:0000269|PubMed:11082044, ECO:0000269|PubMed:16627472, ECO:0000269|PubMed:17320047, ECO:0000269|PubMed:18174177}.
uniprot
proteins
mass_dalton
48585
uniprot
proteins
mutagenesis
MUTAGEN 415; /note="P->L: Loss of DNM1-, SYNJ1- and WASL-binding. Loss of effect on transferrin endocytosis."; /evidence="ECO:0000269|PubMed:11082044
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC).
uniprot
proteins
protein_family
PACSIN family
uniprot
proteins
pubmed
11082044
uniprot
proteins
pubmed
11179684
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16627472
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17320047
uniprot
proteins
pubmed
18174177
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22573331
uniprot
proteins
sequence_length
424
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11082044}. Cell membrane {ECO:0000269|PubMed:11082044}; Peripheral membrane protein {ECO:0000269|PubMed:11082044}; Cytoplasmic side {ECO:0000269|PubMed:11082044}. Note=Detected at the inner aspect of the plasma membrane in myotubes.
uniprot
proteins