Itgb6
entrez
311061
canonical
uniprot
Q6AYF4
canonical
ensembl
ENSRNOG00000008346
resolver
ensembl
ENSRNOG00055000591
resolver
ensembl
ENSRNOG00060008996
resolver
ensembl
ENSRNOG00065020801
resolver
ensp
ENSRNOP00000011030
resolver
ensp
ENSRNOP00055000786
resolver
ensp
ENSRNOP00060011695
resolver
ensp
ENSRNOP00065028386
resolver
enst
ENSRNOT00000011030
resolver
enst
ENSRNOT00055001012
resolver
enst
ENSRNOT00060015070
resolver
enst
ENSRNOT00065035274
resolver
genesymbol
Itgb6
resolver
uniprot_entry
ITB6_RAT
resolver
amino_acid_sequence
MGIELVCLFLLLLGRNDHVQGGCAWSGAETCSDCLLTGPHCAWCSQENFTHLSGAGERCDTPENLLAKGCQLPFIENPVSQVEILQNKPLSVGRQKNSSDIVQIAPQSLVLKLRPGGEQTLQVQVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSRLAKEMSKLTSNFRLGFGSFVEKPVSPFMKTTPEEITNPCSSIPYFCLPTFGFKHILPLTDDAERFNEIVRKQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHFGMDSKLAGIVIPNDGLCHLDNRNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYENYAKLIPGATVGLLQKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFTALCSNGILFPHQKKCSHMKVGDTASFNVSVSITNCEKRSRKLIIKPVGLGDTLEILVSAECDCDCQREVEANSSKCHHGNGSFQCGVCACNPGHMGPRCECGEDMVSTDSCKESPGHPSCSGRGDCYCGQCVCHLSPYGSIYGPYCQCDNFSCLRHKGLLCGDNGDCDCGECVCRDGWTGEYCNCTTSRDACASEDGVLCSGRGDCVCGKCVCRNPGASGPTCERCPTCGDPCNSRRSCIECYLSADGQAQEECEDKCKATGATISEEEFSKDTSVPCSLQGENECLITFLITADNEGKTIIHNISEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIWKLLVSFHDRKEVAKFEAERSKAKWQTGTNPLYRGSTSTFKNVTYKHREKHKVGLSSDG
uniprot
proteins
function
FUNCTION: Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (By similarity). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (By similarity). {ECO:0000250|UniProtKB:P18564, ECO:0000250|UniProtKB:Q9Z0T9}.
uniprot
proteins
mass_dalton
85959
uniprot
proteins
protein_family
Integrin beta chain family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
787
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P18564}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P18564}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P18564}.
uniprot
proteins
transmembrane_region
TRANSMEM 709..729; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins