AEN
entrez
64782
canonical
uniprot
Q8WTP8
canonical
ensembl
ENSG00000181026
resolver
ensp
ENSP00000331944
resolver
ensp
ENSP00000607511
resolver
ensp
ENSP00000789306
resolver
genesymbol
AEN
resolver
genesymbol_syn
ISG20L1
resolver
hgnc
HGNC:25722
resolver
uniprot
C9J571
resolver
uniprot
Q9BSA5
resolver
uniprot
Q9H9X7
resolver
uniprot_entry
AEN_HUMAN
resolver
uniprot_sec
C9J571
resolver
uniprot_sec
Q9BSA5
resolver
uniprot_sec
Q9H9X7
resolver
amino_acid_sequence
MVPREAPESAQCLCPSLTIPNAKDVLRKRHKRRSRQHQRFMARKALLQEQGLLSMPPEPGSSPLPTPFGAATATEAASSGKQCLRAGSGSAPCSRRPAPGKASGPLPSKCVAIDCEMVGTGPRGRVSELARCSIVSYHGNVLYDKYIRPEMPIADYRTRWSGITRQHMRKAVPFQVAQKEILKLLKGKVVVGHALHNDFQALKYVHPRSQTRDTTYVPNFLSEPGLHTRARVSLKDLALQLLHKKIQVGQHGHSSVEDATTAMELYRLVEVQWEQQEARSLWTCPEDREPDSSTDMEQYMEDQYWPDDLAHGSRGGAREAQDRRN
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: Exonuclease with activity against single- and double-stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis. {ECO:0000269|PubMed:16171785, ECO:0000269|PubMed:18264133}.
uniprot
proteins
mass_dalton
36350
uniprot
proteins
mutagenesis
MUTAGEN 114; /note="D->A: Abolishes exonuclease activity; when associated with A-116 and A-258."; /evidence="ECO:0000269|PubMed:18264133"; MUTAGEN 116; /note="E->A: Abolishes exonuclease activity; when associated with A-114 and A-258."; /evidence="ECO:0000269|PubMed:18264133"; MUTAGEN 258; /note="D->A: Abolishes exonuclease activity; when associated with A-114 and A-116."; /evidence="ECO:0000269|PubMed:18264133
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16171785
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
18264133
uniprot
proteins
sequence_length
325
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Nucleus, nucleolus. Note=Localized predomintly in the nucleolus. Translocates from the nucleolus to the nucleoplasm upon apoptosis induction.
uniprot
proteins