Avpr2
entrez
12000
canonical
uniprot
O88721
canonical
ensembl
ENSMUSG00000031390
resolver
ensp
ENSMUSP00000033765
resolver
ensp
ENSMUSP00000099011
resolver
ensp
ENSMUSP00000110037
resolver
enst
ENSMUST00000033765
resolver
enst
ENSMUST00000101470
resolver
enst
ENSMUST00000114395
resolver
genesymbol
Avpr2
resolver
genesymbol_syn
V2r
resolver
uniprot
F6SZF2
resolver
uniprot
F7CGU8
resolver
uniprot
Q3KNZ4
resolver
uniprot
Q3SWS1
resolver
uniprot
Q3SWS4
resolver
uniprot_entry
F6SZF2_MOUSE
resolver
uniprot_entry
F7CGU8_MOUSE
resolver
uniprot_entry
Q3KNZ4_MOUSE
resolver
uniprot_entry
Q3SWS1_MOUSE
resolver
uniprot_entry
Q3SWS4_MOUSE
resolver
uniprot_entry
V2R_MOUSE
resolver
amino_acid_sequence
MILVSTTSAVPGALSSPSSPSNSSQEELLDDRDPLLVRAELALLSTIFVAVALSNGLVLGALIRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLVPGPSERAGRRRRGHRTGSPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPLERPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCAQRHTTHSLGPQDESCATASSSLMKDTPS
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for arginine vasopressin, an antidiuretic that promotes renal water reabsorption. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP). AVPR2 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity. {ECO:0000250|UniProtKB:P30518}.
uniprot
proteins
mass_dalton
40645
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of the P-X-P-P motif promotes association with beta-arrestin ARRB2, leading to receptor desensitization and negative regulation of G protein-coupled receptor signaling. {ECO:0000250|UniProtKB:P30518}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Vasopressin/oxytocin receptor subfamily
uniprot
proteins
pubmed
33052234
uniprot
proteins
sequence_length
371
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P30518}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P30518}.
uniprot
proteins
transmembrane_region
TRANSMEM 39..63; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 78..98; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 114..135; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 160..180; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 201..220; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 272..293; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 309..328; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins