TNIP3
entrez
79931
canonical
uniprot
Q96KP6
canonical
ensembl
ENSG00000050730
resolver
ensp
ENSP00000057513
resolver
ensp
ENSP00000426613
resolver
ensp
ENSP00000427106
resolver
genesymbol
TNIP3
resolver
genesymbol_syn
ABIN3
resolver
genesymbol_syn
LIND
resolver
hgnc
HGNC:19315
resolver
uniprot
A1A574
resolver
uniprot
A8K2Z4
resolver
uniprot
B4DVF5
resolver
uniprot
B4E023
resolver
uniprot
Q96PQ3
resolver
uniprot
Q9H780
resolver
uniprot_entry
TNIP3_HUMAN
resolver
uniprot_sec
A1A574
resolver
uniprot_sec
A8K2Z4
resolver
uniprot_sec
B4DVF5
resolver
uniprot_sec
B4E023
resolver
uniprot_sec
Q96PQ3
resolver
uniprot_sec
Q9H780
resolver
amino_acid_sequence
MAHFVQGTSRMIAAESSTEHKECAEPSTRKNLMNSLEQKIRCLEKQRKELLEVNQQWDQQFRSMKELYERKVAELKTKLDAAERFLSTREKDPHQRQRKDDRQREDDRQRDLTRDRLQREEKEKERLNEELHELKEENKLLKGKNTLANKEKEHYECEIKRLNKALQDALNIKCSFSEDCLRKSRVEFCHEEMRTEMEVLKQQVQIYEEDFKKERSDRERLNQEKEELQQINETSQSQLNRLNSQIKACQMEKEKLEKQLKQMYCPPCNCGLVFHLQDPWVPTGPGAVQKQREHPPDYQWYALDQLPPDVQHKANGLSSVKKVHP
uniprot
proteins
function
FUNCTION: Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding. {ECO:0000269|PubMed:17088249}.
uniprot
proteins
mass_dalton
38943
uniprot
proteins
mutagenesis
MUTAGEN 214..215; /note="ER->AA: Abolishes ubiquitin binding; loss of inhibitory activity on NF-kappa-B activation."; /evidence="ECO:0000269|PubMed:18212736
uniprot
proteins
pubmed
11345586
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17088249
uniprot
proteins
pubmed
18212736
uniprot
proteins
sequence_length
325
uniprot
proteins