Fus
entrez
233908
canonical
uniprot
P56959
canonical
ensembl
ENSMUSG00000030795
resolver
ensp
ENSMUSP00000076801
resolver
ensp
ENSMUSP00000101858
resolver
enst
ENSMUST00000077609
resolver
enst
ENSMUST00000106251
resolver
genesymbol
Fus
resolver
uniprot
F8WHT6
resolver
uniprot
Q3USY4
resolver
uniprot
Q564D0
resolver
uniprot
Q8CFQ9
resolver
uniprot_entry
F8WHT6_MOUSE
resolver
uniprot_entry
FUS_MOUSE
resolver
uniprot_entry
Q3USY4_MOUSE
resolver
uniprot_entry
Q564D0_MOUSE
resolver
uniprot_entry
Q8CFQ9_MOUSE
resolver
amino_acid_sequence
MASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYGQSADTSGYGQSSYGSSYGQTQNTGYGTQSAPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGGSSQSSSYGQPQSGGYGQQSGYGGQQQSYGQQQSSYNPPQGYGQQNQYNSSSGGGGGGGGGNYGQDQSSMSGGGGGGGYGNQDQSGGGGGGYGGGQQDRGGRGRGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFNKFGGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGRGGYDRGGYRGRGGDRGGFRGGRGGGDRGGFGPGKMDSRGEHRQDRRERPY
uniprot
proteins
function
FUNCTION: DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (By similarity). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing. Also binds its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay. Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (By similarity). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (PubMed:16317045, PubMed:25968143). {ECO:0000250|UniProtKB:P35637, ECO:0000269|PubMed:16317045, ECO:0000269|PubMed:25968143}.
uniprot
proteins
mass_dalton
52673
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in its N-terminal serine residues upon induced DNA damage. ATM and DNA-PK are able to phosphorylate FUS N-terminal region. {ECO:0000250|UniProtKB:P35637}.
uniprot
proteins
protein_family
RRM TET family
uniprot
proteins
pubmed
12950080
uniprot
proteins
pubmed
16317045
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
25968143
uniprot
proteins
sequence_length
518
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P35637}. Note=Displays a punctate pattern inside the nucleus and is excluded from nucleoli. {ECO:0000250|UniProtKB:P35637}.
uniprot
proteins