Foxn1
entrez
15218
canonical
uniprot
Q61575
canonical
ensembl
ENSMUSG00000002057
resolver
ensp
ENSMUSP00000103929
resolver
enst
ENSMUST00000108294
resolver
genesymbol
Foxn1
resolver
genesymbol_syn
Fkh19
resolver
genesymbol_syn
Hfh11
resolver
genesymbol_syn
Whn
resolver
uniprot
Q32MU3
resolver
uniprot
Q5SYK1
resolver
uniprot_entry
FOXN1_MOUSE
resolver
uniprot_entry
Q32MU3_MOUSE
resolver
uniprot_entry
Q5SYK1_MOUSE
resolver
amino_acid_sequence
MVSLLPPQSDVTLPGSTRLEGEPQGDLMQAPGLPDSPAPQNKHANFSCSSFVPDGPPERTPSLPPHSPSIASPDPEQIQGHCTAGPGPGSFRLSPSEKYPGFGFEEGPAGSPGRFLKGNHMPFHPYKRHFHEDIFSEAQTAMALDGHSFKTQGALEAFEEIPVDMGDAEAFLPSFPAEAWCNKLPYPSQEHNQILQGSEVKVKPQALDSGPGMYCYQPPLQHMYCSSQPAFHQYSPGGGSYPVPYLGSPHYPYQRIAPQANAEGHQPLFPKPIYSYSILIFMALKNSKTGSLPVSEIYNFMTEHFPYFKTAPDGWKNSVRHNLSLNKCFEKVENKSGSSSRKGCLWALNPSKIDKMQEELQKWKRKDPIAVRKSMAKPEELDSLIGDKREKLGSPLLGCPPPGLAGPGPIRPMAPSAGLSQPLHPMHPAPGPMPGKNPLQDLLGGHAPSCYGQTYPHLSPSLAPSGHQQPLFPQPDGHLELQAQPGTPQDSPLPAHTPPSHGAKLMAEPSSARTMHDTLLPDGDLGTDLDAINPSLTDFDFQGNLWEQLKDDSLALDPLVLVTSSPTSSSMLPPPPAAHCFPPGPCLAETGNEAGELAPPGSGGSGALGDMHLSTLYSAFVELESTPSSAAAGPAVYLSPGSKPLALA
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in FOXN1 are the cause of the nude/severe combined immunodeficiency (SCID) phenotype which is characterized by athymia and hairlessness. Mice develop largely normal hair follicles and produce hair shafts. However, presumably because of a lack of certain hair keratins, the hair shafts that are generated twist and coil in the hair follicle infundibulum, which becomes dilated. Since hair shafts fail to penetrate the epidermis, macroscopic nudity results and generates the grossly misleading impression that nude mice are hairless. {ECO:0000269|PubMed:2288204, ECO:0000269|PubMed:7969402}.
uniprot
proteins
function
FUNCTION: Transcriptional regulator which regulates the development, differentiation, and function of thymic epithelial cells (TECs) both in the prenatal and postnatal thymus. Acts as a master regulator of the TECs lineage development and is required from the onset of differentiation in progenitor TECs in the developing fetus to the final differentiation steps through which TECs mature to acquire their full functionality. Regulates, either directly or indirectly the expression of a variety of genes that mediate diverse aspects of thymus development and function, including MHC Class II, DLL4, CCL25, CTSL, CD40 and PAX1. Regulates the differentiation of the immature TECs into functional cortical TECs (cTECs) and medullary TECs (mTECs) (PubMed:22072979). Essential for maintenance of mTECs population in the postnatal thymus (PubMed:19955175). Involved in the morphogenesis and maintenance of the three-dimensional thymic microstructure which is necessary for a fully functional thymus (PubMed:21109991). Plays an important role in the maintenance of hematopoiesis and particularly T lineage progenitors within the bone marrow niche with age (PubMed:24184560). Essential for the vascularization of the thymus anlage (PubMed:19853842). Promotes the terminal differentiation of epithelial cells in the epidermis and hair follicles, partly by negatively regulating the activity of protein kinase C (PubMed:17459087). {ECO:0000269|PubMed:17459087, ECO:0000269|PubMed:19853842, ECO:0000269|PubMed:19955175, ECO:0000269|PubMed:21109991, ECO:0000269|PubMed:22072979, ECO:0000269|PubMed:24184560}.
uniprot
proteins
mass_dalton
69245
uniprot
proteins
pubmed
16232301
uniprot
proteins
pubmed
17459087
uniprot
proteins
pubmed
19853842
uniprot
proteins
pubmed
19955175
uniprot
proteins
pubmed
21109991
uniprot
proteins
pubmed
22072979
uniprot
proteins
pubmed
2288204
uniprot
proteins
pubmed
23091413
uniprot
proteins
pubmed
23874334
uniprot
proteins
pubmed
24184560
uniprot
proteins
pubmed
7969402
uniprot
proteins
pubmed
9321431
uniprot
proteins
sequence_length
648
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins