Cryz
entrez
362061
canonical
uniprot
Q6AYT0
canonical
ensembl
ENSRNOG00000028319
resolver
ensembl
ENSRNOG00055028469
resolver
ensembl
ENSRNOG00060001677
resolver
ensembl
ENSRNOG00065012760
resolver
ensp
ENSRNOP00000103156
resolver
ensp
ENSRNOP00055040572
resolver
ensp
ENSRNOP00060001686
resolver
ensp
ENSRNOP00065016035
resolver
enst
ENSRNOT00000124823
resolver
enst
ENSRNOT00055049312
resolver
enst
ENSRNOT00060002566
resolver
enst
ENSRNOT00065020829
resolver
genesymbol
Cryz
resolver
uniprot_entry
QOR_RAT
resolver
amino_acid_sequence
MATGQKLMRAIRVFEFGGPEVLKLQSDVVVPAPQSHQVLIKVHACGVNPVETYIRSGTYSRKPALPYTPGSDVAGIIESVGDGVSAFKKGDRVFCFSTVSGGYAEFALSADNTTYPLPETLDFRQGAALGIPYFTACRALFHSARARAGESVLVHGASGGVGLATCQIARAHGLKVLGTAGSEEGKKLVLQNGAHEVFNHKEANYIDKIKTSAGDKGVDVIIEMLANKNLSNDLKLLSCGGRVIVVGCRGSIEINPRDTMAKETSIIGVSLFSSTKEEFQQFAGILQAGIEKGWVKPVIGSEYPLEKAAQAHEDIIHSSGKMGKMILLL
uniprot
proteins
ec_number
1.6.5.5
uniprot
proteins
function
FUNCTION: Multifunctional crystallin endowed with unrelated mRNA stabilization and enzymatic oxidoreductase activities (PubMed:12684230). Binds (AU)-rich elements (ARE) in the 3'-UTR of target mRNA to enhance their stability (PubMed:12684230). Upon metabolic acidosis, stabilizes the mRNA encoding SLC12A1 a cotransporter involved in transepithelial NH4(+) reabsorption in the medullary thick ascending limb in kidney (By similarity). In response to acidosis, also participates to the adaptive increase in renal ammoniagenesis by stabilizing the mRNAs of enzymes involved in glutamine catabolism (PubMed:12684230). By the same mechanism, it also regulates the expression of the antiapoptotic protein BCL2. Beside its mRNA stabilization activity, also catalyzes the reduction of orthoquinones such as 1,2-naphthoquinone or 9,10-phenanthrenequinone in the presence of NADPH in vitro and could be involved in the detoxification of xenobiotics and protection against oxidative stress (By similarity). {ECO:0000250|UniProtKB:P47199, ECO:0000250|UniProtKB:Q08257, ECO:0000269|PubMed:12684230}.
uniprot
proteins
mass_dalton
34975
uniprot
proteins
protein_family
Quinone oxidoreductase subfamily
uniprot
proteins
protein_family
Zinc-containing alcohol dehydrogenase family
uniprot
proteins
pubmed
12684230
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
329
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q08257}.
uniprot
proteins