ARHGAP17
entrez
55114
canonical
uniprot
Q68EM7
canonical
ensembl
ENSG00000140750
resolver
ensembl
ENSG00000288353
resolver
ensp
ENSP00000289968
resolver
ensp
ENSP00000303130
resolver
ensp
ENSP00000556986
resolver
ensp
ENSP00000645763
resolver
ensp
ENSP00000686188
resolver
ensp
ENSP00000754738
resolver
genesymbol
ARHGAP17
resolver
genesymbol_syn
RICH1
resolver
hgnc
HGNC:18239
resolver
uniprot
A8K6M6
resolver
uniprot
Q6ZUS4
resolver
uniprot
Q7Z2F2
resolver
uniprot
Q8NDG2
resolver
uniprot
Q96KS2
resolver
uniprot
Q96KS3
resolver
uniprot
Q96SS8
resolver
uniprot
Q9BVF6
resolver
uniprot
Q9H8U5
resolver
uniprot
Q9NW54
resolver
uniprot_entry
RHG17_HUMAN
resolver
uniprot_sec
A8K6M6
resolver
uniprot_sec
Q6ZUS4
resolver
uniprot_sec
Q7Z2F2
resolver
uniprot_sec
Q8NDG2
resolver
uniprot_sec
Q96KS2
resolver
uniprot_sec
Q96KS3
resolver
uniprot_sec
Q96SS8
resolver
uniprot_sec
Q9BVF6
resolver
uniprot_sec
Q9H8U5
resolver
uniprot_sec
Q9NW54
resolver
amino_acid_sequence
MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSICHHSHKRLVACFQGQHGTDAERRHKKLPLTALAQNMQEASTQLEDSLLGKMLETCGDAENQLALELSQHEVFVEKEIVDPLYGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHKSSGTNFQGLPSKIDTLKEEMDEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHRKALAVLEKTLPEMRAHQDKWAEKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCSTSHLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWARNEGTLAEMAAATSVHVVAVIEPIIQHADWFFPEEVEFNVSEAFVPLTTPSSNHSFHTGNDSDSGTLERKRPASMAVMEGDLVKKESFGVKLMDFQAHRRGGTLNRKHISPAFQPPLPPTDGSTVVPAGPEPPPQSSRAESSSGGGTVPSSAGILEQGPSPGDGSPPKPKDPVSAAVPAPGRNNSQIASGQNQPQAAAGSHQLSMGQPHNAAGPSPHTLRRAVKKPAPAPPKPGNPPPGHPGGQSSSGTSQHPPSLSPKPPTRSPSPPTQHTGQPPGQPSAPSQLSAPRRYSSSLSPIQAPNHPPPQPPTQATPLMHTKPNSQGPPNPMALPSEHGLEQPSHTPPQTPTPPSTPPLGKQNPSLPAPQTLAGGNPETAQPHAGTLPRPRPVPKPRNRPSVPPPPQPPGVHSAGDSSLTNTAPTASKIVTDSNSRVSEPHRSIFPEMHSDSASKDVPGRILLDIDNDTESTAL
uniprot
proteins
function
FUNCTION: Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere. Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000269|PubMed:11431473, ECO:0000269|PubMed:16678097}.
uniprot
proteins
mass_dalton
95437
uniprot
proteins
mutagenesis
MUTAGEN 288; /note="R->A: Loss of function; leading to defects in tight junction maintenance."; /evidence="ECO:0000269|PubMed:11431473
uniprot
proteins
pubmed
11285285
uniprot
proteins
pubmed
11431473
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16678097
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
881
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein. Cytoplasm. Cell junction, tight junction. Note=Associates with membranes and concentrates at sites of cell-cell contact.
uniprot
proteins