Dlat
entrez
235339
canonical
uniprot
Q8BMF4
canonical
ensembl
ENSMUSG00000000168
resolver
ensp
ENSMUSP00000034567
resolver
enst
ENSMUST00000034567
resolver
genesymbol
Dlat
resolver
uniprot
Q8K2G8
resolver
uniprot
Q8R339
resolver
uniprot
Q91ZB1
resolver
uniprot_entry
ODP2_MOUSE
resolver
uniprot_sec
Q8K2G8
resolver
uniprot_sec
Q8R339
resolver
uniprot_sec
Q91ZB1
resolver
amino_acid_sequence
MWRVCARRARSAVPRDGFRARWAALKEGPGAPCGSPRIGPAAVRCGSGIPRYGVRSLCGWSSGSGTVPRNRLLRQLLGSPSRRSYSLPPHQKVPLPSLSPTMQAGTIARWEKKEGEKISEGDLIAEVETDKATVGFESLEECYMAKILVPEGTRDVPVGSIICITVEKPQDIEAFKNYTLDLAAAAAPQAAPAAAPAPAAAPAAPSASAPGSSYPTHMQIVLPALSPTMTMGTVQRWEKKVGEKLSEGDLLAEIETDKATIGFEVQEEGYLAKILVPEGTRDVPLGAPLCIIVEKQEDIAAFADYRPTEVTSLKPQAAPPAPPPVAAVPPTPQPVAPTPSAAPAGPKGRVFVSPLAKKLAAEKGIDLTQVKGTGPEGRIIKKDIDSFVPSKAAPAAAAAMAPPGPRVAPAPAGVFTDIPISNIRRVIAQRLMQSKQTIPHYYLSVDVNMGEVLLVRKELNKMLEGKGKISVNDFIIKASALACLKVPEANSSWMDTVIRQNHVVDVSVAVSTPAGLITPIVFNAHIKGLETIASDVVSLASKAREGKLQPHEFQGGTFTISNLGMFGIKNFSAIINPPQACILAIGASEDKLIPADNEKGFDVASVMSVTLSCDHRVVDGAVGAQWLAEFKKYLEKPITMLL
uniprot
proteins
ec_number
2.3.1.12
uniprot
proteins
function
FUNCTION: The pyruvate dehydrogenase (PDH) complex, catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3);. Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acetyl groups from acetyl-lipoyl moiety generated by the pyruvate dehydrogenase, leading to acetyl-CoA formation. {ECO:0000250|UniProtKB:P10515}.
uniprot
proteins
mass_dalton
67942
uniprot
proteins
post_translational_modification
PTM: Delipoylated at Lys-131 and Lys-258 by SIRT4, delipoylation decreases the PHD complex activity. {ECO:0000250|UniProtKB:P10515}.
uniprot
proteins
protein_family
2-oxoacid dehydrogenase family
uniprot
proteins
pubmed
12108679
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
642
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:P08461}.
uniprot
proteins