Tmc4
entrez
308310
canonical
uniprot
Q496Z4
canonical
ensembl
ENSRNOG00000059741
resolver
ensp
ENSRNOP00000074156
resolver
genesymbol
Tmc4
resolver
uniprot_entry
TMC4_RAT
resolver
amino_acid_sequence
MEESPREAWAQFPAWSSSRKARTGPSLASVLNDLPSAATLRYRGPGVLPWGTLDENDDEGRSLQAFAETAQMESQPSRELPWPMQARRAHRKSQAREQVASGSESRAAYWTQQLSRTKGKMKEGFQTIQPWAWTLKKIGGQFGAGTESYFSLLRFLLFLNLGASVIEVCMKLIPTWLEGAPPGPPGPNISSPCGSYIPHTQGLVTFPTQLFNLLSGEGYLEWSPLFYGFYPPRSNLAITYLCSVFAIGLIYLLFILHRSVSGLKETLLAESDVLTSYSHRVFSAWNFGLCGDMHVRLRQRIILYELQVDLEEAAVRRRATEQTLGQRVKVWSMRALLNLLVLALLGAAFYGIYWATEYTVTLQETPVVQQTPLLKLLVNYLPSIFISVFNFVLPPAFTFIASLEGYTHSRQIVLILLRTVFLRLASLVFLLFSLWNQITCGGNMEAEECKACGYNYKEIPCWETRLGQEMYKLVLFDLLMGLLVTLLIQFPRKILCGLCPGALGRLSGTLEFQVPDEVLGLIYAQTVVWVGSFFCPLLPLINTAKFLILFWLKKITLFSIYSPASRTFRASTANFFFPLVLLVGLAISAVPVLYSIFLIPPSKLCGPFQGKLSIWAQIPESIESLPQTAQNFLYFLGTQAFTVPLLIVSSILMMYTVALANCYGRLISELKRQIETEVQNKVFLAQRAVALSSRNGVS
uniprot
proteins
function
FUNCTION: Voltage-gated chloride channel involved in high-concentration salt taste sensation. Depolarization induced by high NaCl concentration may trigger the activation of TMC4-mediated chloride influx into taste bud cells, helping the return to resting potential. Also allows permeation of organic anions including gluconate, but their current amplitudes at positive potentials are less than that of chloride. Involved in pH and temperature-dependent modulation of salty taste. {ECO:0000250|UniProtKB:Q7Z404}.
uniprot
proteins
mass_dalton
78211
uniprot
proteins
protein_family
TMC family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
698
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 155..175; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 236..256; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 335..355; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 381..401; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 412..432; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 470..490; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 518..538; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 540..560; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 579..599; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 640..660; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins