KDM4E
entrez
390245
canonical
uniprot
B2RXH2
canonical
ensembl
ENSG00000235268
resolver
ensp
ENSP00000397239
resolver
enst
ENST00000450979
resolver
genesymbol
KDM4E
resolver
genesymbol_syn
KDM4DL
resolver
genesymbol_syn
KDM5E
resolver
hgnc
HGNC:37098
resolver
uniprot_entry
KDM4E_HUMAN
resolver
amino_acid_sequence
MKSVHSSPQNTSHTIMTFYPTMEEFADFNTYVAYMESQGAHQAGLAKVIPPKEWKARQMYDDIEDILIATPLQQVTSGQGGVFTQYHKKKKAMRVGQYRRLANSKKYQTPPHQNFADLEQRYWKSHPGNPPIYGADISGSLFEESTKQWNLGHLGTILDLLEQECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKTWYVVPPEHGQHLERLARELFPDISRGCEAFLRHKVALISPTVLKENGIPFNCMTQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKMASQCSCGESTVTFSMDPFVRIVQPESYELWKHRQDLAIVEHTEPRVAESQELSNWRDDIVLRRAALGLRLLPNLTAQCPTQPVSSGHCYNPKGCGTDAVPGSAFQSSAYHTQTQSLTLGMSARVLLPSTGSWGSGRGRGRGQGQGRGCSRGRGHGCCTRELGTEEPTVQPASKRRLLMGTRSRAQGHRPQLPLANDLMTNLSL
uniprot
proteins
ec_number
1.14.11.-
uniprot
proteins
ec_number
1.14.11.66
uniprot
proteins
function
FUNCTION: Histone demethylase that demethylates trimethylated 'Lys-9' of histone H3 into monomethylated form, thereby playing a central role in histone code (PubMed:21914792, PubMed:23451023). Also demethylates trimethylated 'Lys-56' of histone H3 (H3K9me3) to generate the monomethylated state (H3K56me1) (PubMed:23451023). {ECO:0000269|PubMed:21914792, ECO:0000269|PubMed:23451023}.
uniprot
proteins
mass_dalton
56804
uniprot
proteins
protein_family
JHDM3 histone demethylase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
21914792
uniprot
proteins
pubmed
23451023
uniprot
proteins
sequence_length
506
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537}.
uniprot
proteins