LDAF1
entrez
57146
canonical
uniprot
Q96B96
canonical
ensembl
ENSG00000011638
resolver
ensp
ENSP00000233047
resolver
ensp
ENSP00000261388
resolver
ensp
ENSP00000409879
resolver
ensp
ENSP00000459481
resolver
ensp
ENSP00000460687
resolver
ensp
ENSP00000461828
resolver
ensp
ENSP00000580975
resolver
ensp
ENSP00000670703
resolver
ensp
ENSP00000723720
resolver
ensp
ENSP00000723722
resolver
ensp
ENSP00000723723
resolver
ensp
ENSP00000723724
resolver
ensp
ENSP00000723729
resolver
ensp
ENSP00000723730
resolver
enst
ENST00000572258
resolver
enst
ENST00000573487
resolver
genesymbol
LDAF1
resolver
genesymbol_syn
TMEM159
resolver
hgnc
HGNC:30136
resolver
uniprot
A6NMA9
resolver
uniprot
B4DEC1
resolver
uniprot
I3L288
resolver
uniprot
I3NI23
resolver
uniprot
O00323
resolver
uniprot_entry
I3L288_HUMAN
resolver
uniprot_entry
I3NI23_HUMAN
resolver
uniprot_entry
LDAF1_HUMAN
resolver
uniprot_sec
A6NMA9
resolver
uniprot_sec
B4DEC1
resolver
uniprot_sec
O00323
resolver
amino_acid_sequence
MAKEEPQSISRDLQELQKKLSLLIDSFQNNSKVVAFMKSPVGQYLDSHPFLAFTLLVFIVMSAVPVGFFLLIVVLTTLAALLGVIILEGLVISVGGFSLLCILCGLGFVSLAMSGMMIASYVVVSSLISCWFSPRPLTQQNTSCDFLPAMKSAEFEGLYQE
uniprot
proteins
function
FUNCTION: Plays an important role in the formation of lipid droplets during the differentiation and maturation of adipocytes (PubMed:31708432). Together with seipin (BSCL2), defines the sites of lipid droplet formation in the endoplasmic reticulum and promotes the aggregation of triacylglycerol molecules to form the core of a lipid droplet (nucleation) in the endoplasmic reticulum and drive budding of lipid droplets into the cytoplasm (PubMed:31708432). {ECO:0000269|PubMed:31708432}.
uniprot
proteins
mass_dalton
17522
uniprot
proteins
protein_family
LDAF1 family
uniprot
proteins
pubmed
10493829
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15589683
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
30901948
uniprot
proteins
pubmed
31708432
uniprot
proteins
sequence_length
161
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:30901948, ECO:0000269|PubMed:31708432}; Multi-pass membrane protein {ECO:0000255}. Lipid droplet {ECO:0000269|PubMed:30901948, ECO:0000269|PubMed:31708432}. Note=Co-localizes with BSCL2 in the ER, upon LD formation dissociates from BSCL2 and relocalizes to LD surfaces during LD maturation. {ECO:0000269|PubMed:31708432}.
uniprot
proteins
transmembrane_region
TRANSMEM 44..61; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 68..87; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 94..110; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 117..133; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins