Phf13
entrez
230936
canonical
uniprot
Q8K2W6
canonical
ensembl
ENSMUSG00000047777
resolver
ensp
ENSMUSP00000062590
resolver
enst
ENSMUST00000055688
resolver
genesymbol
Phf13
resolver
genesymbol_syn
Spoc1
resolver
uniprot
Q3V230
resolver
uniprot_entry
PHF13_MOUSE
resolver
uniprot_entry
Q3V230_MOUSE
resolver
amino_acid_sequence
MDSDSCAAAFHPEEYSPTCKRRRTVEDFNKFCTFVLAYAGYIPYPKEELPLRSSPSPANSTAGTIDSDGWDTGFSDITPSVPDRCFSHLQPSLLQRAKPSNYLLDRKTTDKLKKKKRRKRRDSDIPVKEGFRESLLKLEAADPYVETPSSPTMQDIPQASADPCSGWDSDTPSSGSCATVSPDQVTEIKTEGKRTIVRQGKQVVFRDEDSTGNDEDIMVDSDDDSWDLVTCFCMKPFAGRPMIECNECHTWIHLSCAKIRKSNVPEVFVCQKCRDSKFDIRRSNRSRMGSRKLFLD
uniprot
proteins
function
FUNCTION: Modulates chromatin structure and DNA damage response by regulating key determinants of chromatin compaction and DNA damage response. Binds H3K4me3-containing chromatin and promotes DNA condensation by recruiting corepressors such as TRIM28 and H3K9 methyltransferase SETDB1. Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis. Increases both chromatin-associated levels and activity of H3K9 methyltransferases, such as SETDB1, thus enhancing H3K9 trimethylation (By similarity). Essential for testicular stem-cell differentiation and sustained spermatogenesis (PubMed:21852425). {ECO:0000250|UniProtKB:Q86YI8, ECO:0000269|PubMed:21852425}.
uniprot
proteins
mass_dalton
33424
uniprot
proteins
post_translational_modification
PTM: Subject to proteasomal degradation. Stable when bound to chromatin. The soluble form is rapidly degraded. {ECO:0000250|UniProtKB:Q86YI8}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21852425
uniprot
proteins
sequence_length
296
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q86YI8}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q86YI8}. Note=Predominantly bound to chromatin, but a minor proportion is also detected in the nucleoplasm. {ECO:0000250|UniProtKB:Q86YI8}.
uniprot
proteins