Bex1
entrez
501625
canonical
uniprot
Q3MKQ2
canonical
ensembl
ENSRNOG00000033844
resolver
ensp
ENSRNOP00000039471
resolver
ensp
ENSRNOP00000098885
resolver
enst
ENSRNOT00000048996
resolver
enst
ENSRNOT00000172286
resolver
genesymbol
Bex1
resolver
genesymbol_syn
Bex2
resolver
uniprot
A0A096MIT8
resolver
uniprot
Q6XUZ8
resolver
uniprot_entry
A0A096MIT8_RAT
resolver
uniprot_entry
BEX1_RAT
resolver
uniprot_sec
Q6XUZ8
resolver
amino_acid_sequence
MESKDQGAKNLNMENDHQKKEEKEEKPQDTIKREPVVAPTFEAGKNCAPRGGRRRFRVRQPIAHYRWDLMHRVGEPQGRMREENVQRFGEDMRQLMEKLRERQLSHSLRAVSTDPPHHDHHDEFCLMP
uniprot
proteins
function
FUNCTION: Signaling adapter molecule involved in p75NTR/NGFR signaling (PubMed:16498402). Plays a role in cell cycle progression and neuronal differentiation (PubMed:16498402). Inhibits neuronal differentiation in response to nerve growth factor (NGF) (PubMed:16498402). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (PubMed:16498402). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity). {ECO:0000250|UniProtKB:Q9R224, ECO:0000269|PubMed:16498402}.
uniprot
proteins
mass_dalton
15248
uniprot
proteins
mutagenesis
MUTAGEN 19; /note="K->E: Does not affect subcellular location."; /evidence="ECO:0000269|PubMed:15958283"; MUTAGEN 45; /note="K->E: Does not affect subcellular location."; /evidence="ECO:0000269|PubMed:15958283"; MUTAGEN 53..55; /note="RRR->AAA: Abolishes nuclear localization."; /evidence="ECO:0000269|PubMed:16498402"; MUTAGEN 105; /note="S->A: Abolishes phosphorylation, leading to degradation by the proteasome."; /evidence="ECO:0000269|PubMed:16498402
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation of Ser-105 protects it from the proteasome. {ECO:0000269|PubMed:16498402}.; PTM: Ubiquitinated. Degraded by the proteasome. {ECO:0000269|PubMed:16498402}.
uniprot
proteins
protein_family
BEX family
uniprot
proteins
pubmed
15033532
uniprot
proteins
pubmed
15958283
uniprot
proteins
pubmed
16498402
uniprot
proteins
sequence_length
128
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15958283, ECO:0000269|PubMed:16498402}. Cytoplasm {ECO:0000269|PubMed:16498402}. Note=Shuttles between the cytoplasm and the nucleus (PubMed:16498402). Predominantly nuclear (PubMed:16498402). {ECO:0000269|PubMed:16498402}.
uniprot
proteins