Pigz
entrez
239827
canonical
uniprot
Q8BTP0
canonical
ensembl
ENSMUSG00000045625
resolver
ensp
ENSMUSP00000057509
resolver
ensp
ENSMUSP00000352591
resolver
enst
ENSMUST00000052174
resolver
genesymbol
Pigz
resolver
uniprot
Q149K0
resolver
uniprot_entry
PIGZ_MOUSE
resolver
uniprot_sec
Q149K0
resolver
amino_acid_sequence
MMVAAQVIWGSFSLLRVLWCLLPQTGYIHPDEFFQSPEVMAEDILGVQATRPWEFYPSSSCRTVVFPLLTSGSTFWLLRLWEELGLWPGLVSGYMLLVGPRFLLTALSFALDWAVYDLAPLWGADRWNALCLLSGSYVTLVFYTRTFSNTIEGLLFTWLLVLVSPGVVRSPTSKKPTPGPRWHRYLLGVILAAGFFNRPTFLAFALAPLSLWGIHRASELGGIRALIQEALVLLPGAALAAVLCVATDSWYFSSLSRSTGVFLTPANFLYYNLDPQNLARHGTHARLTHLAVNGFLLFGVLHAQALQAAWQQLHACLRASPQTGLSRVRGARGLLSSSKSYLLLFYFTPLLLLSAFSHQEARFLIPLLVPLVLLCSPQTQPIPWKGTLVLFNILGALIFGCLHQGGLVPGLKYLEQIVHTPDLSGTTTHYTLLFTHTYMPPQHLLHLSGLGSPVEVVDMGGAEDRVLCQALNNFSRQPACQLAGEPWPCRLFVVTPGTNRHALEKCRFPLKNETLLFPHLTLEDPPALSSLLSGAWRKHLSLHVIELETPVVTKQPKAQP
uniprot
proteins
ec_number
2.4.1.-
uniprot
proteins
function
FUNCTION: Alpha-1,2-mannosyltransferase that catalyzes the transfer of the fourth mannose, via an alpha-1,2 bond, from a dolichol-phosphate-mannose (Dol-P-Man) to a 2-acyl-6-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H6) intermediate to generate a 2-acyl-6-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed M4C) and participates in the twelfth step of the glycosylphosphatidylinositol-anchor biosynthesis. The presence of a fourth mannose in GPI is facultative, suggesting that it only exists in some tissues. {ECO:0000250|UniProtKB:Q86VD9}.
uniprot
proteins
mass_dalton
62043
uniprot
proteins
pathway_participation
PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. {ECO:0000250|UniProtKB:Q86VD9}.
uniprot
proteins
protein_family
Glycosyltransferase 22 family
uniprot
proteins
protein_family
PIGZ subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
560
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q86VD9}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 102..122; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 126..143; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 147..167; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 186..206; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 225..245; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 333..353; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 363..383; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 388..408; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins