KCNU1
entrez
157855
canonical
uniprot
A8MYU2
canonical
ensembl
ENSG00000215262
resolver
ensp
ENSP00000382770
resolver
enst
ENST00000399881
resolver
genesymbol
KCNU1
resolver
genesymbol_syn
KCNMA3
resolver
genesymbol_syn
KCNMC1
resolver
genesymbol_syn
SLO3
resolver
hgnc
HGNC:18867
resolver
uniprot
B4DYE4
resolver
uniprot_entry
KCNU1_HUMAN
resolver
uniprot_sec
B4DYE4
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by changes in cytosolic pH; activated by alkalization (PubMed:23129643, PubMed:24670955). Activated by intracellular Ca(2+) (PubMed:24670955). Despite strong sequence similarity, human KCNU1 channels are significantly more sensitive to activation by internal Ca(2+) and less pH-sensitive than mouse KCNU1 (PubMed:24670955). VU0546110 acts as a selective inhibitor (PubMed:36649421). The auxiliary subunit LRRC52 shifts the activation of KCNU1 to more negative potentials at a given pH (PubMed:38267364). {ECO:0000269|PubMed:23129643, ECO:0000269|PubMed:24670955, ECO:0000269|PubMed:36649421, ECO:0000269|PubMed:38267364}.
uniprot
proteins
amino_acid_sequence
MFQTKLRNETWEDLPKMSCTTEIQAAFILSSFVTFFSGLIILLIFRLIWRSVKKWQIIKGTGIILELFTSGTIARSHVRSLHFQGQFRDHIEMLLSAQTFVGQVLVILVFVLSIGSLIIYFINSADPVGSCSSYEDKTIPIDLVFNAFFSFYFGLRFMAADDKIKFWLEMNSIVDIFTIPPTFISYYLKSNWLGLRFLRALRLLELPQILQILRAIKTSNSVKFSKLLSIILSTWFTAAGFIHLVENSGDPWLKGRNSQNISYFESIYLVMATTSTVGFGDVVAKTSLGRTFIMFFTLGSLILFANYIPEMVELFANKRKYTSSYEALKGKKFIVVCGNITVDSVTAFLRNFLRDKSGEINTEIVFLGETPPSLELETIFKCYLAYTTFISGSAMKWEDLRRVAVESAEACLIIANPLCSDSHAEDISNIMRVLSIKNYDSTTRIIIQILQSHNKVYLPKIPSWNWDTGDNIICFAELKLGFIAQGCLVPGLCTFLTSLFVEQNKKVMPKQTWKKHFLNSMKNKILTQRLSDDFAGMSFPEVARLCFLKMHLLLIAIEYKSLFTDGFCGLILNPPPQVRIRKNTLGFFIAETPKDVRRALFYCSVCHDDVFIPELITNCGCKSRSRQHITVPSVKRMKKCLKGISSRISGQDSPPRVSASTSSISNFTTRTLQHDVEQDSDQLDSSGMFHWCKPTSLDKVTLKRTGKSKYKFRNHIVACVFGDAHSAPMGLRNFVMPLRASNYTRKELKDIVFIGSLDYLQREWRFLWNFPQIYILPGCALYSGDLHAANIEQCSMCAVLSPPPQPSSNQTLVDTEAIMATLTIGSLQIDSSSDPSPSVSEETPGYTNGHNEKSNCRKVPILTELKNPSNIHFIEQLGGLEGSLQETNLHLSTAFSTGTVFSGSFLDSLLATAFYNYHVLELLQMLVTGGVSSQLEQHLDKDKVYGVADSCTSLLSGRNRCKLGLLSLHETILSDVNPRNTFGQLFCGSLDLFGILCVGLYRIIDEEELNPENKRFVITRPANEFKLLPSDLVFCAIPFSTACYKRNEEFSLQKSYEIVNKASQTTETHSDTNCPPTIDSVTETLYSPVYSYQPRTNSLSFPKQIAWNQSRTNSIISSQIPLGDNAKENERKTSDEVYDEDPFAYSEPL
uniprot
proteins
disease_involvement
DISEASE: Spermatogenic failure 79 (SPGF79) [MIM:620196]: An autosomal recessive, male infertility disorder characterized by asthenoteratozoospermia with acrosome hypoplasia, disruption of the mitochondrial sheath, and reduced progressive sperm motility. The disorder is due to an abnormal acrosome reaction and impaired membrane potential after capacitation. {ECO:0000269|PubMed:34980136, ECO:0000269|PubMed:35551387}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+) (PubMed:23129643, PubMed:24670955, PubMed:36649421, PubMed:38267364, PubMed:9452476). Represents the primary spermatozoan K(+) current. The channel underlies a pH-triggered membrane hyperpolarization during the process of sperm capacitation, as sperm encounter the alkaline environment near the ovum in the female reproductive tract, thereby playing an essential for male fertility (PubMed:34980136, PubMed:35551387, PubMed:36649421). {ECO:0000269|PubMed:23129643, ECO:0000269|PubMed:24670955, ECO:0000269|PubMed:34980136, ECO:0000269|PubMed:35551387, ECO:0000269|PubMed:36649421, ECO:0000269|PubMed:38267364, ECO:0000269|PubMed:9452476}.
uniprot
proteins
mass_dalton
129543
uniprot
proteins
protein_family
Calcium-activated (TC 1.A.1.3) subfamily
uniprot
proteins
protein_family
KCa5.1/KCNU1 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
23129643
uniprot
proteins
pubmed
24670955
uniprot
proteins
pubmed
34980136
uniprot
proteins
pubmed
35551387
uniprot
proteins
pubmed
36649421
uniprot
proteins
pubmed
38267364
uniprot
proteins
pubmed
9452476
uniprot
proteins
sequence_length
1149
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O54982}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium, flagellum membrane {ECO:0000269|PubMed:24670955, ECO:0000269|PubMed:38267364}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..45; /note="Helical; Name=Segment S0"; /evidence="ECO:0000255"; TRANSMEM 102..122; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 139..159; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 164..184; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 189..209; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 227..247; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 292..312; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins