Grin2a
entrez
24409
canonical
uniprot
Q00959
canonical
ensembl
ENSRNOG00000033942
resolver
ensp
ENSRNOP00000042235
resolver
enst
ENSRNOT00000044626
resolver
genesymbol
Grin2a
resolver
uniprot
G3V9C5
resolver
uniprot
O08948
resolver
uniprot
Q63728
resolver
uniprot_entry
G3V9C5_RAT
resolver
uniprot_entry
NMDE1_RAT
resolver
uniprot_sec
O08948
resolver
uniprot_sec
Q63728
resolver
activity_regulation
ACTIVITY REGULATION: NMDA glutamate receptor activity is inhibited by nanomolar (nM) concentrations of Zn(2+) in an allosteric way (PubMed:27916457, PubMed:30500536). NMDA glutamate receptor activity is inhibited by a low pH (PubMed:30500536). {ECO:0000269|PubMed:27916457, ECO:0000269|PubMed:30500536}.
uniprot
proteins
amino_acid_sequence
MGRLGYWTLLVLPALLVWRDPAQNAAAEKGPPALNIAVLLGHSHDVTERELRNLWGPEQATGLPLDVNVVALLMNRTDPKSLITHVCDLMSGARIHGLVFGDDTDQEAVAQMLDFISSQTFIPILGIHGGASMIMADKDPTSTFFQFGASIQQQATVMLKIMQDYDWHVFSLVTTIFPGYRDFISFIKTTVDNSFVGWDMQNVITLDTSFEDAKTQVQLKKIHSSVILLYCSKDEAVLILSEARSLGLTGYDFFWIVPSLVSGNTELIPKEFPSGLISVSYDDWDYSLEARVRDGLGILTTAASSMLEKFSYIPEAKASCYGQAEKPETPLHTLHQFMVNVTWDGKDLSFTEEGYQVHPRLVVIVLNKDREWEKVGKWENQTLSLRHAVWPRYKSFSDCEPDDNHLSIVTLEEAPFVIVEDIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKCCKGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSVPFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKGKAPHGPSFTIGKAIWLLWGLVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTANLAAFMIQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTRFNQRGVEDALVSLKTGKLDAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFASTGYGIALQKGSPWKRQIDLALLQFVGDGEMEELETLWLTGICHNEKNEVMSSQLDIDNMAGVFYMLAAAMALSLITFIWEHLFYWKLRFCFTGVCSDRPGLLFSISRGIYSCIHGVHIEEKKKSPDFNLTGSQSNMLKLLRSAKNISNMSNMNSSRMDSPKRATDFIQRGSLIVDMVSDKGNLIYSDNRSFQGKDSIFGDNMNELQTFVANRHKDNLSNYVFQGQHPLTLNESNPNTVEVAVSTESKGNSRPRQLWKKSMESLRQDSLNQNPVSQRDEKTAENRTHSLKSPRYLPEEVAHSDISETSSRATCHREPDNNKNHKTKDNFKRSMASKYPKDCSDVDRTYMKTKASSPRDKIYTIDGEKEPSFHLDPPQFVENITLPENVGFPDTYQDHNENFRKGDSTLPMNRNPLHNEDGLPNNDQYKLYAKHFTLKDKGSPHSEGSDRYRQNSTHCRSCLSNLPTYSGHFTMRSPFKCDACLRMGNLYDIDEDQMLQETGNPATREEVYQQDWSQNNALQFQKNKLRINRQHSYDNILDKPREIDLSRPSRSISLKDRERLLEGNLYGSLFSVPSSKLLGNKSSLFPQGLEDSKRSKSLLPDHASDNPFLHTYGDDQRLVIGRCPSDPYKHSLPSQAVNDSYLRSSLRSTASYCSRDSRGHSDVYISEHVMPYAANKNTMYSTPRVLNSCSNRRVYKKMPSIESDV
uniprot
proteins
function
FUNCTION: Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (Probable) (PubMed:11160393, PubMed:11929923, PubMed:1350383, PubMed:14602821, PubMed:30500536). NMDARs participate in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:16281028, PubMed:23625947, PubMed:24462099, PubMed:27618671, PubMed:27916457, PubMed:28468946, PubMed:30500536, Ref.2). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:11160393, PubMed:11929923, PubMed:14602821, PubMed:23625947, PubMed:24607230, PubMed:28384476, PubMed:28760974, PubMed:9463421, Ref.2). Participates in the synaptic plasticity regulation through activation by the L-glutamate releaseed by BEST1, into the synaptic cleft, upon F2R/PAR-1 activation in astrocyte (By similarity). {ECO:0000250|UniProtKB:P35436, ECO:0000250|UniProtKB:P35438, ECO:0000269|PubMed:11160393, ECO:0000269|PubMed:11929923, ECO:0000269|PubMed:1350383, ECO:0000269|PubMed:14602821, ECO:0000269|PubMed:16281028, ECO:0000269|PubMed:23625947, ECO:0000269|PubMed:24462099, ECO:0000269|PubMed:24607230, ECO:0000269|PubMed:27618671, ECO:0000269|PubMed:27916457, ECO:0000269|PubMed:28384476, ECO:0000269|PubMed:28468946, ECO:0000269|PubMed:28760974, ECO:0000269|PubMed:30500536, ECO:0000269|PubMed:9463421, ECO:0000269|Ref.2, ECO:0000305|Ref.2}.
uniprot
proteins
mass_dalton
165469
uniprot
proteins
mutagenesis
MUTAGEN 233; /note="K->A,R: Nearly abolishes inhibition by Zn(2+)."; /evidence="ECO:0000269|PubMed:27916457"; MUTAGEN 264; /note="N->W: Nearly abolishes inhibition by Zn(2+)."; /evidence="ECO:0000269|PubMed:27916457"; MUTAGEN 282; /note="D->A,H: Nearly abolishes inhibition by Zn(2+)."; /evidence="ECO:0000269|PubMed:27916457"; MUTAGEN 416; /note="F->A: Decreased sensitivity to glutamate."; /evidence="ECO:0000269|PubMed:24462099"; MUTAGEN 730; /note="Y->F,L,M: Strongly decreased sensitivity to glutamate."; /evidence="ECO:0000269|PubMed:24462099"; MUTAGEN 734; /note="V->A: Decreased sensitivity to glutamate."; /evidence="ECO:0000269|PubMed:24462099
uniprot
proteins
protein_family
Glutamate-gated ion channel (TC 1.A.10.1) family
uniprot
proteins
protein_family
NR2A/GRIN2A subfamily
uniprot
proteins
pubmed
11160393
uniprot
proteins
pubmed
11588171
uniprot
proteins
pubmed
11929923
uniprot
proteins
pubmed
12391275
uniprot
proteins
pubmed
1350383
uniprot
proteins
pubmed
14602821
uniprot
proteins
pubmed
16281028
uniprot
proteins
pubmed
16495444
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
22960932
uniprot
proteins
pubmed
23625947
uniprot
proteins
pubmed
24462099
uniprot
proteins
pubmed
24607230
uniprot
proteins
pubmed
26679993
uniprot
proteins
pubmed
27618671
uniprot
proteins
pubmed
27916457
uniprot
proteins
pubmed
28384476
uniprot
proteins
pubmed
28468946
uniprot
proteins
pubmed
28760974
uniprot
proteins
pubmed
30500536
uniprot
proteins
pubmed
31080121
uniprot
proteins
pubmed
7569905
uniprot
proteins
pubmed
8428958
uniprot
proteins
pubmed
9463421
uniprot
proteins
pubmed
9509416
uniprot
proteins
pubmed
9647694
uniprot
proteins
pubmed
9694864
uniprot
proteins
sequence_length
1464
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, dendritic spine {ECO:0000269|PubMed:26679993}. Cell membrane {ECO:0000269|PubMed:11160393, ECO:0000269|PubMed:1350383, ECO:0000269|PubMed:14602821, ECO:0000269|PubMed:16281028, ECO:0000269|PubMed:23625947, ECO:0000269|PubMed:24462099, ECO:0000269|PubMed:27618671, ECO:0000269|PubMed:27916457, ECO:0000269|PubMed:28384476, ECO:0000269|PubMed:28468946, ECO:0000269|PubMed:28760974, ECO:0000269|PubMed:8428958}; Multi-pass membrane protein {ECO:0000269|PubMed:30500536}. Synapse {ECO:0000250|UniProtKB:P35436}. Postsynaptic cell membrane {ECO:0000269|PubMed:26679993, ECO:0000269|PubMed:9509416}; Multi-pass membrane protein {ECO:0000269|PubMed:30500536}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P35436}. Postsynaptic density membrane {ECO:0000269|PubMed:26679993}. Note=Expression at the dendrite cell membrane and at synapses is regulated by SORCS2 and the retromer complex. {ECO:0000250|UniProtKB:P35436}.
uniprot
proteins
transmembrane_region
TRANSMEM 555..575; /note="Helical"; /evidence="ECO:0000269|PubMed:30500536, ECO:0007744|PDB:6MM9, ECO:0007744|PDB:6MMA, ECO:0007744|PDB:6MMB, ECO:0007744|PDB:6MMG, ECO:0007744|PDB:6MMH, ECO:0007744|PDB:6MMI, ECO:0007744|PDB:6MMJ, ECO:0007744|PDB:6MMK, ECO:0007744|PDB:6MML, ECO:0007744|PDB:6MMM, ECO:0007744|PDB:6MMN, ECO:0007744|PDB:6MMP, ECO:0007744|PDB:6MMR, ECO:0007744|PDB:6MMS, ECO:0007744|PDB:6MMT, ECO:0007744|PDB:6MMU, ECO:0007744|PDB:6MMV, ECO:0007744|PDB:6MMW, ECO:0007744|PDB:6MMX"; TRANSMEM 625..646; /note="Helical"; /evidence="ECO:0000269|PubMed:30500536, ECO:0007744|PDB:6MM9, ECO:0007744|PDB:6MMA, ECO:0007744|PDB:6MMB, ECO:0007744|PDB:6MMG, ECO:0007744|PDB:6MMH, ECO:0007744|PDB:6MMI, ECO:0007744|PDB:6MMJ, ECO:0007744|PDB:6MMK, ECO:0007744|PDB:6MML, ECO:0007744|PDB:6MMM, ECO:0007744|PDB:6MMN, ECO:0007744|PDB:6MMP, ECO:0007744|PDB:6MMR, ECO:0007744|PDB:6MMS, ECO:0007744|PDB:6MMT, ECO:0007744|PDB:6MMU, ECO:0007744|PDB:6MMV, ECO:0007744|PDB:6MMW, ECO:0007744|PDB:6MMX"; TRANSMEM 815..835; /note="Helical"; /evidence="ECO:0000269|PubMed:30500536, ECO:0007744|PDB:6MM9, ECO:0007744|PDB:6MMA, ECO:0007744|PDB:6MMB, ECO:0007744|PDB:6MMG, ECO:0007744|PDB:6MMH, ECO:0007744|PDB:6MMI, ECO:0007744|PDB:6MMJ, ECO:0007744|PDB:6MMK, ECO:0007744|PDB:6MML, ECO:0007744|PDB:6MMM, ECO:0007744|PDB:6MMN, ECO:0007744|PDB:6MMP, ECO:0007744|PDB:6MMR, ECO:0007744|PDB:6MMS, ECO:0007744|PDB:6MMT, ECO:0007744|PDB:6MMU, ECO:0007744|PDB:6MMV, ECO:0007744|PDB:6MMW, ECO:0007744|PDB:6MMX
uniprot
proteins