LEPR
entrez
3953
canonical
uniprot
P48357
canonical
ensembl
ENSG00000116678
resolver
ensp
ENSP00000330393
resolver
ensp
ENSP00000340884
resolver
ensp
ENSP00000360098
resolver
ensp
ENSP00000360099
resolver
ensp
ENSP00000483390
resolver
ensp
ENSP00000650863
resolver
genesymbol
LEPR
resolver
genesymbol_syn
DB
resolver
genesymbol_syn
OBR
resolver
hgnc
HGNC:6554
resolver
uniprot
Q13592
resolver
uniprot
Q13593
resolver
uniprot
Q13594
resolver
uniprot
Q4G138
resolver
uniprot
Q92919
resolver
uniprot
Q92920
resolver
uniprot
Q92921
resolver
uniprot_entry
LEPR_HUMAN
resolver
uniprot_entry
Q4G138_HUMAN
resolver
uniprot_sec
Q13592
resolver
uniprot_sec
Q13593
resolver
uniprot_sec
Q13594
resolver
uniprot_sec
Q92919
resolver
uniprot_sec
Q92920
resolver
uniprot_sec
Q92921
resolver
amino_acid_sequence
MICQKFCVVLLHWEFIYVITAFNLSYPITPWRFKLSCMPPNSTYDYFLLPAGLSKNTSNSNGHYETAVEPKFNSSGTHFSNLSKTTFHCCFRSEQDRNCSLCADNIEGKTFVSTVNSLVFQQIDANWNIQCWLKGDLKLFICYVESLFKNLFRNYNYKVHLLYVLPEVLEDSPLVPQKGSFQMVHCNCSVHECCECLVPVPTAKLNDTLLMCLKITSGGVIFQSPLMSVQPINMVKPDPPLGLHMEITDDGNLKISWSSPPLVPFPLQYQVKYSENSTTVIREADKIVSATSLLVDSILPGSSYEVQVRGKRLDGPGIWSDWSTPRVFTTQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEKIPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINISCETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGFYECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLKISWEKPVFPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKSVSLPVPDLCAVYAVQVRCKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDSLCSVQRYVINHHTSCNGTWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANFNLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKNLNEDGEIKWLRISSSVKKYYIHDHFIPIEKYQFSLYPIFMEGVGKPKIINSFTQDDIEKHQSDAGLYVIVPVIISSSILLLGTLLISHQRMKKLFWEDVPNPKNCSWAQGLNFQKPETFEHLFIKHTASVTCGPLLLEPETISEDISVDTSWKNKDEMMPTTVVSLLSTTDLEKGSVCISDQFNSVNFSEAEGTEVTYEDESQRQPFVKYATLISNSKPSETGEEQGLINSSVTKCFSSKNSPLKDSFSNSSWEIEAQAFFILSDQHPNIISPHLTFSEGLDELLKLEGNFPEENNDKKSIYYLGVTSIKKRESGVLLTDKSRVSCPFPAPCLFTDIRVLQDSCSHFVENNINLGTSSKKTFASYMPQFQTCSTQTHKIMENKMCDLTV
uniprot
proteins
disease_involvement
DISEASE: Leptin receptor deficiency (LEPRD) [MIM:614963]: A rare disease characterized by normal levels of serum leptin, hyperphagia and severe obesity from an early age. Additional features include alterations in immune function, and delayed puberty due to hypogonadotropic hypogonadism. {ECO:0000269|PubMed:25751111, ECO:0000269|PubMed:9537324}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Receptor for hormone LEP/leptin (Probable) (PubMed:22405007). On ligand binding, mediates LEP central and peripheral effects through the activation of different signaling pathways such as JAK2/STAT3 and MAPK cascade/FOS. In the hypothalamus, LEP acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones (By similarity) (PubMed:9537324). In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic and affects innate and adaptive immunity (PubMed:12504075, PubMed:25060689, PubMed:8805376). Control of energy homeostasis and melanocortin production (stimulation of POMC and full repression of AgRP transcription) is mediated by STAT3 signaling, whereas distinct signals regulate NPY and the control of fertility, growth and glucose homeostasis. Involved in the regulation of counter-regulatory response to hypoglycemia by inhibiting neurons of the parabrachial nucleus. Has a specific effect on T lymphocyte responses, differentially regulating the proliferation of naive and memory T -ells. Leptin increases Th1 and suppresses Th2 cytokine production (By similarity). {ECO:0000250|UniProtKB:P48356, ECO:0000269|PubMed:12504075, ECO:0000269|PubMed:22405007, ECO:0000269|PubMed:25060689, ECO:0000269|PubMed:8805376, ECO:0000269|PubMed:9537324, ECO:0000305|PubMed:25232147}.; FUNCTION: [Isoform A]: May transport LEP across the blood-brain barrier. Binds LEP and mediates LEP endocytosis. Does not induce phosphorylation of and activate STAT3. {ECO:0000250|UniProtKB:P48356}.; FUNCTION: [Isoform E]: Antagonizes Isoform A and isoform B-mediated LEP binding and endocytosis. {ECO:0000250|UniProtKB:P48356}.
uniprot
proteins
mass_dalton
132494
uniprot
proteins
mutagenesis
MUTAGEN 986; /note="Y->F: Greatly reduced PTPN11 binding; no PTPN11 phosphorylation; no effect on STAT3 phosphorylation."; /evidence="ECO:0000269|PubMed:9600917"; MUTAGEN 1078..1079; /note="YY->FF: No effect on PTPN11 nor STAT3 phosphorylation."; /evidence="ECO:0000269|PubMed:9600917"; MUTAGEN 1141; /note="Y->F: No effect on PTPN11 phosphorylation; no STAT3 phosphorylation."; /evidence="ECO:0000269|PubMed:9600917
uniprot
proteins
post_translational_modification
PTM: On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-986 is required for complete binding and activation of PTPN11, ERK/FOS activation,for interaction with SOCS3 and SOCS3 mediated inhibition of leptin signaling. Phosphorylation on Tyr-1141 is required for STAT3 binding/activation. Phosphorylation of Tyr-1079 has a more accessory role. {ECO:0000250|UniProtKB:P48356}.
uniprot
proteins
protein_family
Type 2 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
10896907
uniprot
proteins
pubmed
12504075
uniprot
proteins
pubmed
16052473
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
18987736
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
22405007
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25060689
uniprot
proteins
pubmed
25232147
uniprot
proteins
pubmed
25751111
uniprot
proteins
pubmed
8548812
uniprot
proteins
pubmed
8616721
uniprot
proteins
pubmed
8666155
uniprot
proteins
pubmed
8805376
uniprot
proteins
pubmed
9061609
uniprot
proteins
pubmed
9144432
uniprot
proteins
pubmed
9158141
uniprot
proteins
pubmed
9175732
uniprot
proteins
pubmed
9287054
uniprot
proteins
pubmed
9537324
uniprot
proteins
pubmed
9600917
uniprot
proteins
pubmed
9786864
uniprot
proteins
pubmed
9860295
uniprot
proteins
pubmed
9929394
uniprot
proteins
sequence_length
1165
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19159218}; Single-pass type I membrane protein {ECO:0000305}. Basolateral cell membrane {ECO:0000269|PubMed:19159218}.; SUBCELLULAR LOCATION: [Isoform E]: Secreted {ECO:0000250|UniProtKB:P48356}.
uniprot
proteins
transmembrane_region
TRANSMEM 840..862; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins