O88573
uniprot
O88573
canonical
amino_acid_sequence
MAAHSSLYNEDRNLLRIREKERRNQEAHQEKEAFPEKAPLFPEPYKTAKGDELSSRIQTMLGDYEEMKEFLSSKSHPHRLDGSEDRPGKPRYPLGHDRGNGAASSSLRTHVYHQPIHTSAPGSRPVGNISHSPKMAQPRMEPSLHTKIYDGPRLTQDHLSQGHCSRKCDRRAEGDSAPERKLSPLISSLPSPVPPLSPVHSRLQGTSKAHSSGVSSKSCCVAKSSKDLVAKAQDKETPHDGLVAVTSLGSAPPQPPCQTFPPPPLPSKSAAMQQKPTAYVRPMDGQDQAPSESPELKLPLEDYGQQSFEKPDLKVPAKAKLTRLRMPSQSVEQPYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSRFPFPTKDPLHVSPATQSQKQYDTPSKTHPNPQQGTSMLEDDLQLSDSEDSDTEQATEKPPSPPAPPSAPQTLPEPVASAHSSSGESESSESDSSSDSESESSSSDSEEEEENEPLETRAPEPEPPTTNKWQLDNWLTKVNQPSVPLDGRGSTESPQWRQESKGVAEGSSDQQHPDSKDPLPKSSSKTLRGPSEGPSLGRGAVRNPPLNRNPHLGKPWAANNPGNPPRLRPGRAQASSQAESEVGPLPYGSKEQTSKDRPKVKTKGRPRAVGSREPKPEVPAPTPQAAVPRPKPPVPTPSEKRKHKSSTAPSKAPSAPQPPKDSAGDRNPEHSALVSLTQSQGPSHSSRGSSGSVRTSGCRQAVIAQGDGCKDKLLLPLRDTKLLSPLRDSPPPTSLVVKITLDLLTRIPQPLGKGSRPRKAEDKQLSAGKKQDSETKSCDSSSRVTKKRKVTQKKSTVTRDTNWISRRASSSSSHTESSRTKAPRSSSENSRKEMLPPASASSVSSSSSSQKPSRPAQKRPRPDEDTCSQEPPRSASSTKSSSTDPPAPKHRKVQARGSEHKGSSGDAANAANPFPVPSLPNGNAKPGKPQVKSDRQQADFHMKEAKKLKCKAETMVDKAGKAFKYLEAVLSFIECGMASESESSAKSAYAVYSETIDLIRYVMSLKCFSDNTMPAQEKIFAVLCLRCQSLLNMAMFRCKKDTVMKYSRTLSEHFKSTSKVAQAPSPCTARSTGVPSPLSPMPSPASSVGSQSSAGSSMGSVGVTATVSTPVSIQNMTSSYVTITSHVLTAFSLWEQAEALTRKNKEFFAQLSTKVRVLALNSSLVDLVHYTRQGLQRLKQSPKGP
uniprot
proteins
function
FUNCTION: Plays an essential role in the activation of transcription elongation from RNA polymerase II promoters, after transcriptional pausing in response to DNA damage. Upon DNA damage, AFF1-mediated transcriptional recovery requires AFF1 poly-ADP-ribosylation by PARP1. {ECO:0000250|UniProtKB:P51825}.
uniprot
proteins
mass_dalton
131558
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by SIAH1. {ECO:0000250|UniProtKB:P51825}.; PTM: Poly-ADP-ribosylated by PARP1 on serine residues between aminoacids 588-906 in response to DNA damage; poly-ADP-ribosylation by PARP1 enhances AFF1 stability after DNA damage by preventing SIAH1-mediated ubiquitination and degradation. {ECO:0000250|UniProtKB:P51825}.
uniprot
proteins
protein_family
AF4 family
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9880680
uniprot
proteins
sequence_length
1216
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P51825}. Note=Associates with chromatin and is recruited to DNA damage sites in a PARP1-dependent manner. {ECO:0000250|UniProtKB:P51825}.
uniprot
proteins