Nell2
entrez
81734
canonical
uniprot
Q62918
canonical
ensembl
ENSRNOG00000006235
resolver
ensembl
ENSRNOG00065017359
resolver
ensp
ENSRNOP00000008985
resolver
ensp
ENSRNOP00000098277
resolver
ensp
ENSRNOP00065022951
resolver
enst
ENSRNOT00065028985
resolver
genesymbol
Nell2
resolver
genesymbol_syn
Nel
resolver
uniprot
A1E5S7
resolver
uniprot
C8CB44
resolver
uniprot
Q561K2
resolver
uniprot
Q8R417
resolver
uniprot_entry
NELL2_RAT
resolver
uniprot_sec
A1E5S7
resolver
uniprot_sec
C8CB44
resolver
uniprot_sec
Q561K2
resolver
uniprot_sec
Q8R417
resolver
amino_acid_sequence
MHAMESRVLLRTFCVILGLEAVWGLGVDPSLQIDVLSELELGESTAGVRQVPGLHNGTKAFLFQDSPRSIKAPIATAERFFQKLRNKHEFTILVTLKQIHLNSGVILSIHHLDHRYLELESSGHRNEIRLHYRSGTHRPHTEVFPYILADAKWHKLSLAFSASHLILHIDCNKIYERVVEMPSTDLPLGTTFWLGQRNNAHGYFKGIMQDVQLLVMPQGFIAQCPDLNRTCPTCNDFHGLVQKIMELQDILSKTSAKLSRAEQRMNRLDQCYCERTCTMKGTTYREFESWTDGCKNCTCLNGTIQCETLVCPAPDCPAKSAPAYVDGKCCKECKSTCQFQGRSYFEGERSTVFSASGMCVLYECKDQTMKLVENAGCPALDCPESHQIALSHSCCKVCKGYDFCSEKHTCMENSVCRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFLCICQTGYIRIDDYSCTEHDECLTNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSEGFVQCDSRANCINLPGWYHCECRDGYHDNGMFAPGGESCEDIDECGTGRHSCANDTICFNLDGGYDCRCPHGKNCTGDCVHDGKVKHNGQIWVLENDRCSVCSCQTGFVMCRRMVCDCENPTVDLSCCPECDPRLSSQCLHQNGETVYNSGDTWVQDCRQCRCLQGEVDCWPLACPEVECEFSVLPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECTLCQCKNGHVCCSVDPQCLQEL
uniprot
proteins
function
FUNCTION: Plays multiple roles In neural tissues, regulates neuronal proliferation, survival, differentiation, polarization, as well as axon guidance and synaptic functions (PubMed:12941464, PubMed:18547942, PubMed:32597395). Plays an important role in axon development during neuronal differentiation through the MAPK intracellular signaling pathway (PubMed:32597395). Via binding to its receptor ROBO3, plays a role in axon guidance, functioning as a repulsive axon guidance cue that contributes to commissural axon guidance to the midline (By similarity). Required for neuron survival through the modulation of MAPK signaling pathways too (PubMed:12941464). Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (PubMed:18547942). {ECO:0000250|UniProtKB:Q61220, ECO:0000269|PubMed:12941464, ECO:0000269|PubMed:18547942, ECO:0000269|PubMed:32597395}.; FUNCTION: Epididymal-secreted protein that signals through a ROS1-pathway to regulate the epididymal initial segment (IS) maturation, sperm maturation and male fertility. {ECO:0000250|UniProtKB:Q61220}.; FUNCTION: [Isoform 2]: Acts as an endogenous inhibitor of PRKCB in glia. {ECO:0000269|PubMed:25450684}.
uniprot
proteins
mass_dalton
91334
uniprot
proteins
pubmed
10548494
uniprot
proteins
pubmed
10600492
uniprot
proteins
pubmed
12941464
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17196548
uniprot
proteins
pubmed
18547942
uniprot
proteins
pubmed
19931511
uniprot
proteins
pubmed
25450684
uniprot
proteins
pubmed
32597395
uniprot
proteins
sequence_length
819
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Secreted {ECO:0000269|PubMed:10548494, ECO:0000269|PubMed:17196548, ECO:0000269|PubMed:18547942}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:17196548}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000269|PubMed:19931511}.
uniprot
proteins