Mdh1
entrez
24551
canonical
uniprot
O88989
canonical
ensembl
ENSRNOG00000008103
resolver
ensembl
ENSRNOG00055008079
resolver
ensembl
ENSRNOG00060014463
resolver
ensembl
ENSRNOG00065005943
resolver
ensp
ENSRNOP00000011429
resolver
ensp
ENSRNOP00055010983
resolver
ensp
ENSRNOP00060019706
resolver
ensp
ENSRNOP00065006387
resolver
enst
ENSRNOT00000011429
resolver
enst
ENSRNOT00055013672
resolver
enst
ENSRNOT00060024739
resolver
enst
ENSRNOT00065008968
resolver
genesymbol
Mdh1
resolver
genesymbol_syn
Mdh
resolver
uniprot
O88585
resolver
uniprot
Q6PCV2
resolver
uniprot_entry
MDHC_RAT
resolver
uniprot_sec
O88585
resolver
uniprot_sec
Q6PCV2
resolver
amino_acid_sequence
MSEPIRVLVTGAAGQIAYSLLYSIGNGSVFGKDQPIILVLLDITPMMGVLDGVLMELQDCALPLLQDVIATDKEEVAFKDLDVAVLVGSMPRREGMERKDLLKANVKIFKSQGAALEKYAKKSVKVIVVGNPANTNCLTASKSAPSIPKENFSCLTRLDHNRAKSQIALKLGVTADDVKNVIIWGNHSSTQYPDVNHAKVKLQGKEVGVYEALKDDSWLKGEFITTVQQRGAAVIKARKLSSAMSAAKAISDHIRDIWFGTPEGEFVSMGVISDGNSYGVPDDLLYSFPVVIKNKTWKFVEGLPINDFSREKMDLTAKELTEEKETAFEFLSSA
uniprot
proteins
ec_number
1.1.1.37
uniprot
proteins
function
FUNCTION: Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS). {ECO:0000250|UniProtKB:P40925}.
uniprot
proteins
mass_dalton
36483
uniprot
proteins
post_translational_modification
PTM: ISGylated. {ECO:0000250|UniProtKB:P40925}.; PTM: Acetylation at Lys-118 dramatically enhances enzymatic activity and promotes adipogenic differentiation. {ECO:0000250|UniProtKB:P40925}.
uniprot
proteins
protein_family
LDH/MDH superfamily
uniprot
proteins
protein_family
MDH type 2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
334
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P40925}.
uniprot
proteins