Atraid
entrez
381629
canonical
uniprot
Q6PGD0
canonical
ensembl
ENSMUSG00000013622
resolver
ensp
ENSMUSP00000013766
resolver
ensp
ENSMUSP00000144085
resolver
genesymbol
Atraid
resolver
genesymbol_syn
0610007C21Rik
resolver
genesymbol_syn
Apr3
resolver
uniprot
A8C1S6
resolver
uniprot
Q3UAH4
resolver
uniprot
Q810Q3
resolver
uniprot
Q9DD14
resolver
uniprot_entry
A8C1S6_MOUSE
resolver
uniprot_entry
ARAID_MOUSE
resolver
uniprot_sec
Q3UAH4
resolver
uniprot_sec
Q810Q3
resolver
uniprot_sec
Q9DD14
resolver
amino_acid_sequence
MASRESGGSRAAALLLVLGVERALALPEICTLCPGGMHNLSRVAAYCEDTSKLMQARCCLNQKGTILGLDLQNCSLKDPGPNFLQAYTAIIIDLQANPLKDDLANTFRGFTQLQTLILPQDVPCPGGSNAWDNVTSFKDKQICQGQRDLCNSTGSPEMCPENGSCASDGPGLLQCVCADGFHGYKCMRQGSFSLLMFFGILGSTTLAISILLWGTQRRKAKAS
uniprot
proteins
function
FUNCTION: Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway (By similarity). In osteoclasts, forms a transporter complex with ATRAID for nitrogen-containing-bisphosphonates (N-BPs) required for releasing N-BP molecules that have trafficked to lysosomes through fluid-phase endocytosis into the cytosol (PubMed:29745899). {ECO:0000250|UniProtKB:Q6UW56, ECO:0000269|PubMed:29745899}.
uniprot
proteins
mass_dalton
23858
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
29745899
uniprot
proteins
sequence_length
223
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus envelope {ECO:0000250|UniProtKB:Q6UW56}. Cell membrane {ECO:0000250|UniProtKB:Q6UW56}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q6UW56}. Lysosome membrane {ECO:0000269|PubMed:29745899}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with NELL1 on the nuclear envelope and the perinuclear region. {ECO:0000250|UniProtKB:Q6UW56}.
uniprot
proteins
transmembrane_region
TRANSMEM 194..214; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins