BEST4
entrez
266675
canonical
uniprot
Q8NFU0
canonical
ensembl
ENSG00000142959
resolver
ensp
ENSP00000361281
resolver
ensp
ENSP00000551898
resolver
ensp
ENSP00000551899
resolver
ensp
ENSP00000551900
resolver
ensp
ENSP00000551901
resolver
enst
ENST00000372207
resolver
enst
ENST00000881840
resolver
enst
ENST00000881841
resolver
enst
ENST00000881842
resolver
genesymbol
BEST4
resolver
genesymbol_syn
VMD2L2
resolver
hgnc
HGNC:17106
resolver
uniprot
Q5JR93
resolver
uniprot_entry
BEST4_HUMAN
resolver
uniprot_sec
Q5JR93
resolver
amino_acid_sequence
MTVSYTLKVAEARFGGFSGLLLRWRGSIYKLLYKEFLLFGALYAVLSITYRLLLTQEQRYVYAQVARYCNRSADLIPLSFVLGFYVTLVVNRWWSQYTSIPLPDQLMCVISASVHGVDQRGRLLRRTLIRYANLASVLVLRSVSTRVLKRFPTMEHVVDAGFMSQEERKKFESLKSDFNKYWVPCVWFTNLAAQARRDGRIRDDIALCLLLEELNKYRAKCSMLFHYDWISIPLVYTQVVTIAVYSFFALSLVGRQFVEPEAGAAKPQKLLKPGQEPAPALGDPDMYVPLTTLLQFFFYAGWLKVAEQIINPFGEDDDDFETNQLIDRNLQVSLLSVDEMYQNLPPAEKDQYWDEDQPQPPYTVATAAESLRPSFLGSTFNLRMSDDPEQSLQVEASPGSGRPAPAAQTPLLGRFLGVGAPSPAISLRNFGRVRGTPRPPHLLRFRAEEGGDPEAAARIEEESAESGDEALEP
uniprot
proteins
function
FUNCTION: Ligand-gated anion channel that allows the movement of anions across cell membranes when activated by Calcium (Ca2+) (PubMed:12907679, PubMed:18400985). Mediates the movement of hydrogencarbonate and chloride (PubMed:12907679, PubMed:18400985). {ECO:0000269|PubMed:12907679, ECO:0000269|PubMed:18400985}.
uniprot
proteins
mass_dalton
53497
uniprot
proteins
protein_family
Anion channel-forming bestrophin (TC 1.A.46) family
uniprot
proteins
protein_family
Calcium-sensitive chloride channel subfamily
uniprot
proteins
pubmed
12032738
uniprot
proteins
pubmed
12907679
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18400985
uniprot
proteins
sequence_length
473
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 32..51; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O76090"; TRANSMEM 61..82; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O76090"; TRANSMEM 238..255; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O76090"; TRANSMEM 290..303; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O76090
uniprot
proteins