PLBD1
entrez
79887
canonical
uniprot
Q6P4A8
canonical
ensembl
ENSG00000121316
resolver
ensp
ENSP00000240617
resolver
enst
ENST00000240617
resolver
genesymbol
PLBD1
resolver
genesymbol_syn
Lylap
resolver
hgnc
HGNC:26215
resolver
uniprot
A8K4E9
resolver
uniprot
Q9BVV3
resolver
uniprot
Q9H625
resolver
uniprot_entry
LYLAP_HUMAN
resolver
uniprot_sec
A8K4E9
resolver
uniprot_sec
Q9BVV3
resolver
uniprot_sec
Q9H625
resolver
amino_acid_sequence
MTRGGPGGRPGLPQPPPLLLLLLLLPLLLVTAEPPKPAGVYYATAYWMPAEKTVQVKNVMDKNGDAYGFYNNSVKTTGWGILEIRAGYGSQTLSNEIIMFVAGFLEGYLTAPHMNDHYTNLYPQLITKPSIMDKVQDFMEKQDKWTRKNIKEYKTDSFWRHTGYVMAQIDGLYVGAKKRAILEGTKPMTLFQIQFLNSVGDLLDLIPSLSPTKNGSLKVFKRWDMGHCSALIKVLPGFENILFAHSSWYTYAAMLRIYKHWDFNVIDKDTSSSRLSFSSYPGFLESLDDFYILSSGLILLQTTNSVFNKTLLKQVIPETLLSWQRVRVANMMADSGKRWADIFSKYNSGTYNNQYMVLDLKKVKLNHSLDKGTLYIVEQIPTYVEYSEQTDVLRKGYWPSYNVPFHEKIYNWSGYPLLVQKLGLDYSYDLAPRAKIFRRDQGKVTDTASMKYIMRYNNYKKDPYSRGDPCNTICCREDLNSPNPSPGGCYDTKVADIYLASQYTSYAISGPTVQGGLPVFRWDRFNKTLHQGMPEVYNFDFITMKPILKLDIK
uniprot
proteins
ec_number
3.4.11.-
uniprot
proteins
function
FUNCTION: Lysosomal processive monoaminopeptidase that preferentially cleaves hydrophobic amino acids, with strong preference for leucine residues. Plays a key role in the degradation of hydrophobic transmembrane domains within the lysosome. {ECO:0000269|PubMed:40146846}.
uniprot
proteins
mass_dalton
63255
uniprot
proteins
mutagenesis
MUTAGEN 228; /note="C->A: Blocks autocatalytic cleavage irrespective of pH."; /evidence="ECO:0000269|PubMed:40146846
uniprot
proteins
post_translational_modification
PTM: Proteolytically activated within lysosomes. Undergoes autocatalytic cleavage into an N-terminal A chain and a C-terminal B chain (PubMed:40146846). Both chains A and B remain associated in the mature protein (By similarity). An additional maturation step involves the removal of a segment spanning residues Leu-209-227-Cys, which occludes the active site (PubMed:40146846). {ECO:0000250|UniProtKB:Q9GL30, ECO:0000269|PubMed:40146846}.
uniprot
proteins
protein_family
Ntn hydrolase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
19019078
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
40146846
uniprot
proteins
sequence_length
553
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:40146846}.
uniprot
proteins