RGS17
entrez
26575
canonical
uniprot
Q9UGC6
canonical
ensembl
ENSG00000091844
resolver
ensp
ENSP00000206262
resolver
ensp
ENSP00000356194
resolver
enst
ENST00000206262
resolver
enst
ENST00000367225
resolver
genesymbol
RGS17
resolver
genesymbol_syn
RGSZ2
resolver
hgnc
HGNC:14088
resolver
uniprot
Q5TF49
resolver
uniprot
Q8TD61
resolver
uniprot
Q9UJS8
resolver
uniprot_entry
RGS17_HUMAN
resolver
uniprot_sec
Q5TF49
resolver
uniprot_sec
Q8TD61
resolver
uniprot_sec
Q9UJS8
resolver
amino_acid_sequence
MRKRQQSQNEGTPAVSQAPGNQRPNNTCCFCWCCCCSCSCLTVRNEERGENAGRPTHTTKMESIQVLEECQNPTAEEVLSWSQNFDKMMKAPAGRNLFREFLRTEYSEENLLFWLACEDLKKEQNKKVIEEKARMIYEDYISILSPKEVSLDSRVREVINRNLLDPNPHMYEDAQLQIYTLMHRDSFPRFLNSQIYKSFVESTAGSSSES
uniprot
proteins
function
FUNCTION: Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:15096504). Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G proteins (By similarity). {ECO:0000250|UniProtKB:Q9QZB0, ECO:0000269|PubMed:15096504}.
uniprot
proteins
mass_dalton
24359
uniprot
proteins
post_translational_modification
PTM: N- and O-glycosylated in synapsomal membranes. {ECO:0000250|UniProtKB:Q9QZB0}.; PTM: Serine phosphorylated in synapsomal membranes. {ECO:0000250|UniProtKB:Q9QZB0}.; PTM: Sumoylated with SUMO1 and SUM02 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits (By similarity). Desumoylated by HINT1 (By similarity). {ECO:0000250|UniProtKB:Q9QZB0}.
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15096504
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18434541
uniprot
proteins
sequence_length
210
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9QZB0}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q9QZB0}. Nucleus {ECO:0000250|UniProtKB:Q9QZB0}. Cytoplasm {ECO:0000250|UniProtKB:Q9QZB0}.
uniprot
proteins