Casp2
entrez
64314
canonical
uniprot
P55215
canonical
ensembl
ENSRNOG00000016707
resolver
ensembl
ENSRNOG00055028158
resolver
ensembl
ENSRNOG00060008547
resolver
ensembl
ENSRNOG00065016049
resolver
ensp
ENSRNOP00000022672
resolver
genesymbol
Casp2
resolver
genesymbol_syn
Ich1
resolver
uniprot
O35398
resolver
uniprot
O55194
resolver
uniprot
Q9WUI6
resolver
uniprot_entry
CASP2_RAT
resolver
uniprot_sec
O35398
resolver
uniprot_sec
O55194
resolver
uniprot_sec
Q9WUI6
resolver
amino_acid_sequence
MAASSGRSQSSLHRKGLMAADRRSRILAVCGMHPDHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQAKGGSFSQNVELLNLLPKRGPQAFDAFCEALRETRQGHLEDLLLTTLSDIQHILPPLSCDYDSSLPFSVCESCPPHKQSRLSTDTMEHSLDNGDGPPCLQVKPCTPEFYQAHYQLAYRLQSQPRGLALVMSNVHFTGEKDLEFRSGGDVDHTTLVTLFKLLGYNVHVLYDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGGIYGVDGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAQSPGCEESDAGKEELMKMRLPTRSDMICGYACLKGNAAMRNTKRGSWYIEALTQVFSERACDMHVADMLVKVNALIKEREGYAPGTEFHRCKEMSEYCSTLCQQLYLFPGYPPT
uniprot
proteins
ec_number
3.4.22.55
uniprot
proteins
function
FUNCTION: Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (By similarity). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (By similarity). {ECO:0000250|UniProtKB:P42575}.
uniprot
proteins
mass_dalton
50728
uniprot
proteins
post_translational_modification
PTM: The mature protease can process its own propeptide, but not that of other caspases. {ECO:0000250}.
uniprot
proteins
protein_family
Peptidase C14A family
uniprot
proteins
pubmed
12067235
uniprot
proteins
pubmed
16639714
uniprot
proteins
pubmed
7588240
uniprot
proteins
pubmed
9427555
uniprot
proteins
pubmed
9530276
uniprot
proteins
sequence_length
452
uniprot
proteins