Ly96
entrez
17087
canonical
uniprot
Q9JHF9
canonical
ensembl
ENSMUSG00000025779
resolver
ensp
ENSMUSP00000026881
resolver
ensp
ENSMUSP00000140411
resolver
enst
ENSMUST00000026881
resolver
enst
ENSMUST00000190366
resolver
genesymbol
Ly96
resolver
genesymbol_syn
Esop1
resolver
genesymbol_syn
Md2
resolver
uniprot
A0A087WQZ9
resolver
uniprot
Q14AM4
resolver
uniprot
Q64HC9
resolver
uniprot_entry
A0A087WQZ9_MOUSE
resolver
uniprot_entry
LY96_MOUSE
resolver
uniprot_entry
Q14AM4_MOUSE
resolver
uniprot_entry
Q64HC9_MOUSE
resolver
amino_acid_sequence
MLPFILFSTLLSPILTESEKQQWFCNSSDAIISYSYCDHLKFPISISSEPCIRLRGTNGFVHVEFIPRGNLKYLYFNLFISVNSIELPKRKEVLCHGHDDDYSFCRALKGETVNTSIPFSFEGILFPKGHYRCVAEAIAGDTEEKLFCLNFTIIHRRDVN
uniprot
proteins
function
FUNCTION: Binds bacterial lipopolysaccharide (LPS) (PubMed:22532668). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria. Enhances TLR4-dependent activation of NF-kappa-B. Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10725698). {ECO:0000250|UniProtKB:Q9Y6Y9, ECO:0000269|PubMed:10725698, ECO:0000269|PubMed:20133493, ECO:0000269|PubMed:24380872}.
uniprot
proteins
mass_dalton
18394
uniprot
proteins
mutagenesis
MUTAGEN 126; /note="F->A: Abolishes dimerization of the TLR4 complex and stimulation of TNF production in response to bacterial lipopolysaccharide."; /evidence="ECO:0000269|PubMed:24380872
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:17803912}.
uniprot
proteins
pubmed
10725698
uniprot
proteins
pubmed
10891475
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17803912
uniprot
proteins
pubmed
20133493
uniprot
proteins
pubmed
22532668
uniprot
proteins
pubmed
24380872
uniprot
proteins
sequence_length
160
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000269|PubMed:10725698, ECO:0000269|PubMed:20133493, ECO:0000305|PubMed:24380872}. Secreted {ECO:0000269|PubMed:10891475}. Note=Retained in the extracellular space at the cell surface by interaction with TLR4. {ECO:0000269|PubMed:10725698, ECO:0000269|PubMed:20133493, ECO:0000305|PubMed:24380872}.
uniprot
proteins