Pex14
entrez
64460
canonical
uniprot
Q642G4
canonical
ensembl
ENSRNOG00000013498
resolver
ensembl
ENSRNOG00055022387
resolver
ensembl
ENSRNOG00060027265
resolver
ensembl
ENSRNOG00065010914
resolver
ensp
ENSRNOP00000078609
resolver
ensp
ENSRNOP00055031323
resolver
ensp
ENSRNOP00060039523
resolver
ensp
ENSRNOP00065013626
resolver
enst
ENSRNOT00055038516
resolver
enst
ENSRNOT00060047482
resolver
enst
ENSRNOT00065017774
resolver
genesymbol
Pex14
resolver
uniprot
Q9Z2Z4
resolver
uniprot_entry
PEX14_RAT
resolver
uniprot_sec
Q9Z2Z4
resolver
amino_acid_sequence
MASSEQAEQPNQPSSSPGSENVVPREPLIATAVKFLQNSRVRQSPLATRRAFLKKKGLTDEEIDLAFQQSGTASDEPSPVGPATPVVPVQPPHLISQPYSPGGSRWRDYGALAIILAGIAFGFHQLYKKYLLPLILGGREDRKQLERMAASLSELSGSVAQTVTQVQTTLASVQELLRQQQQKVQELAHELAAAKATTSTNWILESQNINELKSEINSLKGLLLNRRQFPPSPSAPKIPSWQIPVKSPSPSSPAAVNHHSSSDISPVSNESPSSSPGKDGHSPEGSTATYRLLGPQEEGEGVVDVKGQVRMEVQGEEEKREDEEGEEDEDDDVSHVDEEDVLGVQREDRRGGDGQINEQVEKLRRPEGASNESERD
uniprot
proteins
function
FUNCTION: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:19122147). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Plays a key role for peroxisome movement through a direct interaction with tubulin (By similarity). {ECO:0000250|UniProtKB:O75381, ECO:0000250|UniProtKB:P53112, ECO:0000269|PubMed:19122147}.
uniprot
proteins
mass_dalton
40936
uniprot
proteins
mutagenesis
MUTAGEN 35; /note="F->A: Abolished interaction with PEX5, leading to impaired peroxisomal import of proteins."; /evidence="ECO:0000269|PubMed:19122147"; MUTAGEN 52; /note="F->A: Abolished interaction with PEX5, leading to impaired peroxisomal import of proteins."; /evidence="ECO:0000269|PubMed:19122147
uniprot
proteins
protein_family
Peroxin-14 family
uniprot
proteins
pubmed
10212238
uniprot
proteins
pubmed
12488033
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19122147
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
30414318
uniprot
proteins
sequence_length
376
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:12488033, ECO:0000269|PubMed:30414318}; Single-pass membrane protein {ECO:0000269|PubMed:30414318}.
uniprot
proteins
transmembrane_region
TRANSMEM 109..126; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins