Tab3
entrez
66724
canonical
uniprot
Q571K4
canonical
ensembl
ENSMUSG00000035476
resolver
ensp
ENSMUSP00000039668
resolver
ensp
ENSMUSP00000293293
resolver
ensp
ENSMUSP00000293294
resolver
ensp
ENSMUSP00000293295
resolver
ensp
ENSMUSP00000293296
resolver
enst
ENSMUST00000048250
resolver
genesymbol
Tab3
resolver
genesymbol_syn
Kiaa4135
resolver
genesymbol_syn
Map3k7ip3
resolver
uniprot
B1ASY9
resolver
uniprot
Q9D5S8
resolver
uniprot_entry
B1ASY9_MOUSE
resolver
uniprot_entry
Q9D5S8_MOUSE
resolver
uniprot_entry
TAB3_MOUSE
resolver
amino_acid_sequence
MAQNSPQLDIQVLHDLRQRFPEIPEGVVSQCMLQNNNNLEACCRALSQESSKYLYMEYHSPEDNRMNRNRLLHINLGIHSPSSYHPGDGAHLNGGRTLVHSSSDGHIDPQHTAGKQLICLVQEPHSAPAVVAATPNYNPFFMNEQNRSAATPPSQPPQQPSSMQTGMNPSAMQGPSPPPPPPSYMHIPRYSTNPITVTVSQNLPSGQTVPRALQILPQIPSNLYGSPGSIFIRQTSQSSSGRQTPQNAPWQSSPQGPVPHYSQRPLPVYPHQQNYQPSQYSPKQQQIPQSVYHSPPPSQCPSPFSSPQHQVQPPQLGHPSSHVFMPPSPSTTPPHLYQQGPPSYQKPGSHSVAYLPYTASSLPKGSMKKIEITVEPSQRPGTAITRSPSPISNQPSPRNQHSLYTATTPPSSSPSRGISSQPKPPFSVNPVYITYTQPTGPSCAPSPSPRVIPNPTTVFKITVGRATTENLLNLVDQEERSAAPEPIQPISVIPGSGGEKGNHKYQRSSSSGSDDYAYTQALLLHQRARMERLAKQLKLEKEELERLKAEVNSMEHDLMQRRLRRVSCTTAIPTPEEMTRLRSTNRQLQINVDCTLKEVDLLQSRGNFDPKAINNFYDHIEPGPVVPPKPSKKDSSDSCAIERKARRISVTSKAPVDIHDAQAAAADEHLSICKQSARTQPRDEDYEGAPWNCDSCTFLNHPALNRCEQCEMPRYT
uniprot
proteins
function
FUNCTION: Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1. {ECO:0000250|UniProtKB:Q8N5C8}.
uniprot
proteins
mass_dalton
79029
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; following IL1 stimulation or TRAF6 overexpression. Ubiquitinated by AMFR via 'Lys-27'-linked polyubiquitination; leading to TAK1/MAP3K7 activation. {ECO:0000250|UniProtKB:Q8N5C8}.; PTM: Degraded in a lysosome-dependent manner following interaction with TRIM38. {ECO:0000250|UniProtKB:Q8N5C8}.; PTM: Phosphorylated at Ser-510 by MAPKAPK2 and MAPKAPK3 following IL1 treatment. {ECO:0000250|UniProtKB:Q8N5C8}.
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19927120
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
716
uniprot
proteins