CHTOP
entrez
26097
canonical
uniprot
Q9Y3Y2
canonical
ensembl
ENSG00000160679
resolver
ensp
ENSP00000357679
resolver
ensp
ENSP00000357683
resolver
ensp
ENSP00000385228
resolver
ensp
ENSP00000484038
resolver
enst
ENST00000614256
resolver
genesymbol
CHTOP
resolver
genesymbol_syn
C1orf77
resolver
genesymbol_syn
FOP
resolver
hgnc
HGNC:24511
resolver
uniprot
A0A087X1B7
resolver
uniprot
D3DV55
resolver
uniprot
Q0VAQ8
resolver
uniprot
Q2VPI9
resolver
uniprot
Q5T7Y8
resolver
uniprot
Q5T7Y9
resolver
uniprot
Q5T7Z0
resolver
uniprot
Q6NSM4
resolver
uniprot
Q6PB28
resolver
uniprot
Q8WYT9
resolver
uniprot
Q9BUC5
resolver
uniprot
Q9H034
resolver
uniprot
Q9H2L0
resolver
uniprot_entry
A0A087X1B7_HUMAN
resolver
uniprot_entry
CHTOP_HUMAN
resolver
uniprot_sec
D3DV55
resolver
uniprot_sec
Q0VAQ8
resolver
uniprot_sec
Q2VPI9
resolver
uniprot_sec
Q5T7Y8
resolver
uniprot_sec
Q5T7Y9
resolver
uniprot_sec
Q5T7Z0
resolver
uniprot_sec
Q6NSM4
resolver
uniprot_sec
Q6PB28
resolver
uniprot_sec
Q8WYT9
resolver
uniprot_sec
Q9BUC5
resolver
uniprot_sec
Q9H034
resolver
uniprot_sec
Q9H2L0
resolver
amino_acid_sequence
MAAQSAPKVVLKSTTKMSLNERFTNMLKNKQPTPVNIRASMQQQQQLASARNRRLAQQMENRPSVQAALKLKQSLKQRLGKSNIQARLGRPIGALARGAIGGRGLPIIQRGLPRGGLRGGRATRTLLRGGMSLRGQNLLRGGRAVAPRMGLRRGGVRGRGGPGRGGLGRGAMGRGGIGGRGRGMIGRGRGGFGGRGRGRGRGRGALARPVLTKEQLDNQLDAYMSKTKGHLDAELDAYMAQTDPETND
uniprot
proteins
function
FUNCTION: Plays an important role in the ligand-dependent activation of estrogen receptor target genes (PubMed:19858291). May play a role in the silencing of fetal globin genes (PubMed:20688955). Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (By similarity). Plays an important role in the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC is recruited to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis (PubMed:25284789). {ECO:0000250|UniProtKB:Q9CY57, ECO:0000269|PubMed:19858291, ECO:0000269|PubMed:20688955, ECO:0000269|PubMed:25284789}.; FUNCTION: Required for effective mRNA nuclear export and is a component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Stimulates DDX39B ATPase and helicase activities. In cooperation with ALYREF/THOC4 enhances NXF1 RNA binding activity (PubMed:23299939). {ECO:0000269|PubMed:23299939}.
uniprot
proteins
mass_dalton
26397
uniprot
proteins
mutagenesis
MUTAGEN 195; /note="R->A: Loss of 5hmc binding; when associated with A-197; A-199; A-201 and A-203."; /evidence="ECO:0000269|PubMed:25284789"; MUTAGEN 197; /note="R->A: Loss of 5hmc binding; when associated with A-195; A-199; A-201 and A-203."; /evidence="ECO:0000269|PubMed:25284789"; MUTAGEN 199; /note="R->A: Loss of 5hmc binding; when associated with A-195; A-197; A-201 and A-203."; /evidence="ECO:0000269|PubMed:25284789"; MUTAGEN 201; /note="R->A: Loss of 5hmc binding; when associated with A-195; A-197; A-199 and A-203."; /evidence="ECO:0000269|PubMed:25284789"; MUTAGEN 203; /note="R->A: Loss of 5hmc binding; when associated with A-195; A-197; A-199 and A-201."; /evidence="ECO:0000269|PubMed:25284789
uniprot
proteins
post_translational_modification
PTM: Asymmetrically methylated by PRMT1 (PubMed:25284789). Symmetrically methylated by PRMT5 (By similarity). {ECO:0000250|UniProtKB:Q9CY57, ECO:0000269|PubMed:25284789}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19254951
uniprot
proteins
pubmed
19858291
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20688955
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23299939
uniprot
proteins
pubmed
23826332
uniprot
proteins
pubmed
25284789
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
248
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19254951}. Nucleus, nucleolus {ECO:0000269|PubMed:19254951}. Nucleus, nucleoplasm {ECO:0000269|PubMed:23826332}. Nucleus speckle {ECO:0000269|PubMed:23299939, ECO:0000269|PubMed:23826332}. Note=Mostly associated with facultative heterochromatin (By similarity). Localizes to regions surrounding nuclear speckles known as perispeckles in which TREX complex assembly seems to occur (PubMed:23826332). {ECO:0000250|UniProtKB:Q9CY57, ECO:0000269|PubMed:23826332}.
uniprot
proteins