NRAS
entrez
4893
canonical
uniprot
P01111
canonical
ensembl
ENSG00000213281
resolver
ensp
ENSP00000358548
resolver
ensp
ENSP00000601069
resolver
enst
ENST00000369535
resolver
enst
ENST00000931010
resolver
genesymbol
NRAS
resolver
genesymbol_syn
HRAS1
resolver
hgnc
HGNC:7989
resolver
uniprot
A0A024R0K0
resolver
uniprot
Q14971
resolver
uniprot
Q15104
resolver
uniprot
Q15282
resolver
uniprot
Q5U091
resolver
uniprot_entry
Q5U091_HUMAN
resolver
uniprot_entry
RASN_HUMAN
resolver
uniprot_sec
A0A024R0K0
resolver
uniprot_sec
Q14971
resolver
uniprot_sec
Q15104
resolver
uniprot_sec
Q15282
resolver
activity_regulation
ACTIVITY REGULATION: Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).
uniprot
proteins
amino_acid_sequence
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLCVFAINNSKSFADINLYREQIKRVKDSDDVPMVLVGNKCDLPTRTVDTKQAHELAKSYGIPFIETSAKTRQGVEDAFYTLVREIRQYRMKKLNSSDDGTQGCMGLPCVVM
uniprot
proteins
disease_involvement
DISEASE: Leukemia, juvenile myelomonocytic (JMML) [MIM:607785]: An aggressive pediatric myelodysplastic syndrome/myeloproliferative disorder characterized by malignant transformation in the hematopoietic stem cell compartment with proliferation of differentiated progeny. Patients have splenomegaly, enlarged lymph nodes, rashes, and hemorrhages. {ECO:0000269|PubMed:17332249}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Noonan syndrome 6 (NS6) [MIM:613224]: A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells. {ECO:0000269|PubMed:19966803}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: RAS-associated autoimmune leukoproliferative disorder 1 (RALD1) [MIM:614470]: A disorder characterized by lymphoproliferation with chronic accumulation of non-malignant lymphocytes, defective lymphocyte apoptosis, autoimmunity, and an increased risk for the development of hematologic malignancies. {ECO:0000269|PubMed:17517660}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Melanocytic nevus syndrome, congenital (CMNS) [MIM:137550]: A syndrome characterized by congenital pigmentary skin lesions which can occur at any site and can cover most of the body surface. These lesions may or may not be hairy. Congenital melanocytic nevi are associated with neuromelanosis (the presence of melanin-producing cells within the brain parenchyma or leptomeninges). Less commonly they are associated with malignant melanoma in childhood, both in the skin and the central nervous system. CMNS patients also tend to have a characteristic facial appearance, including wide or prominent forehead, periorbital fullness, small short nose with narrow nasal bridge, round face, full cheeks, prominent premaxilla, and everted lower lip. {ECO:0000269|PubMed:18633438, ECO:0000269|PubMed:23392294}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Melanosis, neurocutaneous (NCMS) [MIM:249400]: A rare congenital disease characterized by the presence of giant or multiple melanocytic nevi on the skin, foci of melanin-producing cells within the brain parenchyma, and infiltration of leptomeninges by abnormal melanin deposits. Neurologic abnormalities include seizures, hydrocephalus, arachnoid cysts, tumors, and syringomyelia. Some patients may develop malignant melanoma. {ECO:0000269|PubMed:23392294}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Keratinocytic non-epidermolytic nevus (KNEN) [MIM:162900]: Epidermal nevi of the common, non-organoid and non-epidermolytic type are benign skin lesions and may vary in their extent from a single (usually linear) lesion to widespread and systematized involvement. They may be present at birth or develop early during childhood. {ECO:0000269|PubMed:22499344}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Thyroid cancer, non-medullary, 2 (NMTC2) [MIM:188470]: A form of non-medullary thyroid cancer (NMTC), a cancer characterized by tumors originating from the thyroid follicular cells. NMTCs represent approximately 95% of all cases of thyroid cancer and are classified into papillary, follicular, Hurthle cell, and anaplastic neoplasms. {ECO:0000269|PubMed:12727991}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Signal transducer in the Ras-MAPK signaling pathway that regulates cell proliferation and survival (PubMed:30712867). Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:30712867). Recognized by LZTR1 that mediates its ubiquitination by a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex (PubMed:40934300). {ECO:0000269|PubMed:30712867, ECO:0000269|PubMed:40934300}.
uniprot
proteins
mass_dalton
21229
uniprot
proteins
mutagenesis
MUTAGEN 89; /note="S->A: Abolished phosphorylation by STK19."; /evidence="ECO:0000269|PubMed:30712867"; MUTAGEN 164; /note="R->A: Loss of GTP-binding activity."; MUTAGEN 169..170; /note="KK->RR: In N-Ras-2KR mutant; decreased fatty-acylation."; /evidence="ECO:0000269|PubMed:29239724"; MUTAGEN 181; /note="C->S: Loss of plasma membrane localization."; /evidence="ECO:0000269|PubMed:26701913
uniprot
proteins
post_translational_modification
PTM: Palmitoylated by the ZDHHC9-GOLGA7 complex (PubMed:16000296). Depalmitoylated by ABHD17A, ABHD17B and ABHD17C (PubMed:26701913). A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi (PubMed:15705808, PubMed:16000296, PubMed:2661017, PubMed:26701913). {ECO:0000269|PubMed:15705808, ECO:0000269|PubMed:16000296, ECO:0000269|PubMed:2661017, ECO:0000269|PubMed:26701913}.; PTM: Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs). {ECO:0000250|UniProtKB:P01116}.; PTM: Fatty-acylated at Lys-169 and/or Lys-170. {ECO:0000269|PubMed:29239724}.; PTM: Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes. {ECO:0000305|PubMed:30442762}.; PTM: Phosphorylation at Ser-89 enhances NRAS association with its downstream effectors. {ECO:0000269|PubMed:30712867}.; PTM: (Microbial infection) Glucosylated at Thr-35 by P.sordellii toxin TcsL. {ECO:0000269|PubMed:19744486}.
uniprot
proteins
protein_family
Ras family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
12727991
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15705808
uniprot
proteins
pubmed
16000296
uniprot
proteins
pubmed
17332249
uniprot
proteins
pubmed
17517660
uniprot
proteins
pubmed
18633438
uniprot
proteins
pubmed
1970154
uniprot
proteins
pubmed
19744486
uniprot
proteins
pubmed
19966803
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21278800
uniprot
proteins
pubmed
22499344
uniprot
proteins
pubmed
23392294
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
2661017
uniprot
proteins
pubmed
26701913
uniprot
proteins
pubmed
29239724
uniprot
proteins
pubmed
2991860
uniprot
proteins
pubmed
2998510
uniprot
proteins
pubmed
30442762
uniprot
proteins
pubmed
30712867
uniprot
proteins
pubmed
3102434
uniprot
proteins
pubmed
3276402
uniprot
proteins
pubmed
3295562
uniprot
proteins
pubmed
35768504
uniprot
proteins
pubmed
35830882
uniprot
proteins
pubmed
35831509
uniprot
proteins
pubmed
36175670
uniprot
proteins
pubmed
3856237
uniprot
proteins
pubmed
40934300
uniprot
proteins
pubmed
6086315
uniprot
proteins
pubmed
6587382
uniprot
proteins
pubmed
6616621
uniprot
proteins
sequence_length
189
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15705808, ECO:0000269|PubMed:26701913}; Lipid-anchor {ECO:0000269|PubMed:15705808, ECO:0000269|PubMed:26701913}; Cytoplasmic side {ECO:0000269|PubMed:15705808, ECO:0000269|PubMed:26701913}. Golgi apparatus membrane {ECO:0000269|PubMed:15705808, ECO:0000269|PubMed:26701913}; Lipid-anchor {ECO:0000269|PubMed:15705808, ECO:0000269|PubMed:26701913}. Note=Shuttles between the plasma membrane and the Golgi apparatus. {ECO:0000269|PubMed:15705808, ECO:0000269|PubMed:26701913}.
uniprot
proteins