Reg3g
entrez
24620
canonical
uniprot
P42854
canonical
ensembl
ENSRNOG00000006579
resolver
ensembl
ENSRNOG00055020560
resolver
ensembl
ENSRNOG00060002124
resolver
ensembl
ENSRNOG00065005422
resolver
ensp
ENSRNOP00000008665
resolver
ensp
ENSRNOP00055028451
resolver
ensp
ENSRNOP00060002268
resolver
ensp
ENSRNOP00065005624
resolver
enst
ENSRNOT00000008665
resolver
enst
ENSRNOT00055035097
resolver
enst
ENSRNOT00060003313
resolver
enst
ENSRNOT00065008039
resolver
genesymbol
Reg3g
resolver
genesymbol_syn
Pap3
resolver
uniprot_entry
REG3G_RAT
resolver
activity_regulation
ACTIVITY REGULATION: [Regenerating islet-derived protein 3-gamma 15 kDa form]: Lipopolysaccharide inhibits pore-forming activity, explaining why is bactericidal for Gram-positive but not Gram-negative bacteria. {ECO:0000250|UniProtKB:Q06141}.
uniprot
proteins
amino_acid_sequence
MLPRVALTTMSWMLLSSLMLLSQVQGEDAKEDVPTSRISCPKGSRAYGSYCYALFSVSKSWFDADLACQKRPSGHLVSVLSGSEASFVSSLIKSSGNSGQNVWIGLHDPTLGQEPNRGGWEWSNADVMNYFNWETNPSSVSGSHCGTLTRASGFLRWRENNCISELPYVCKFKA
uniprot
proteins
function
FUNCTION: Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. {ECO:0000250|UniProtKB:O09049}.; FUNCTION: Acts as a hormone in response to different stimuli like anti-inflammatory signals, such as IL17A, or gut microbiome. Is secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways. Induced by IL17A in keratinocytes, regulates keratinocyte proliferation and differentiation after skin injury. In parallel, inhibits skin inflammation through the inhibition of inflammatory cytokines such as IL6 and TNF. Induced by IL22 in lung epithelial cells, inhibits cytokine production and regulates allergic airway inflammation. Induced in small intestine by inulin-enriched diet and Lactobacillus gasseri enriched microbiome, plays a role in the improvement of gut barrier function, the regulation of energy balance and glucose levels. Modulates microbiota composition in duodenal contents. Produced by nociceptor in response to endotoxins, prevents endotoxic death by targeting kynurenine pathway in microglia. {ECO:0000250|UniProtKB:O09049}.; FUNCTION: [Regenerating islet-derived protein 3-gamma 16.5 kDa form]: Has bacteriostatic activity. {ECO:0000250|UniProtKB:O09049}.; FUNCTION: [Regenerating islet-derived protein 3-gamma 15 kDa form]: Has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. {ECO:0000250|UniProtKB:O09049}.
uniprot
proteins
mass_dalton
19144
uniprot
proteins
post_translational_modification
PTM: Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity. {ECO:0000250}.
uniprot
proteins
pubmed
23588857
uniprot
proteins
pubmed
7717998
uniprot
proteins
pubmed
8241280
uniprot
proteins
sequence_length
174
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23588857}. Cytoplasm {ECO:0000269|PubMed:23588857}.
uniprot
proteins