Ncoa2
entrez
17978
canonical
uniprot
Q61026
canonical
ensembl
ENSMUSG00000005886
resolver
ensp
ENSMUSP00000006037
resolver
ensp
ENSMUSP00000069509
resolver
ensp
ENSMUSP00000080413
resolver
ensp
ENSMUSP00000249379
resolver
ensp
ENSMUSP00000249380
resolver
ensp
ENSMUSP00000249381
resolver
enst
ENSMUST00000006037
resolver
enst
ENSMUST00000068304
resolver
enst
ENSMUST00000081713
resolver
genesymbol
Ncoa2
resolver
genesymbol_syn
Grip1
resolver
genesymbol_syn
Src2
resolver
genesymbol_syn
Tif2
resolver
uniprot
E9PV80
resolver
uniprot
E9QMH9
resolver
uniprot
O09001
resolver
uniprot
P97759
resolver
uniprot
Q8BN74
resolver
uniprot
Q8C961
resolver
uniprot
Q8CAG7
resolver
uniprot
Q8CBM5
resolver
uniprot
Q8CE59
resolver
uniprot_entry
E9PV80_MOUSE
resolver
uniprot_entry
NCOA2_MOUSE
resolver
uniprot_entry
Q8BN74_MOUSE
resolver
uniprot_entry
Q8C961_MOUSE
resolver
uniprot_entry
Q8CAG7_MOUSE
resolver
uniprot_entry
Q8CBM5_MOUSE
resolver
uniprot_entry
Q8CE59_MOUSE
resolver
uniprot_sec
E9QMH9
resolver
uniprot_sec
O09001
resolver
uniprot_sec
P97759
resolver
amino_acid_sequence
MSGMGENTSDPSRAETRKRKECPDQLGPSPKRSTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVNLEGSVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSMVNGGSWSGEPPRRSSHTFNCRMLVKPLPDSEEEGHDSQEAHQKYEAMQCFAVSQPKSIKEEGEDLQSCLICVARRVPMKERPTLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLVRRCIQKFHTQHEGESLSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQTTNEPQLVISLHMLHREQNVCVMNPDLTGQAMGKPLNPISSSSPAHQALCSGNPGQDMTLGSNINFPMNGPKEQMGMPMGRFGGSGGMNHVSGMQATTPQGSNYALKMNSPSQSSPGMNPGQASSVLSPRQRMSPGVAGSPRIPPSQFSPAGSLHSPVGVCSSTGNSHSYTNSSLNALQALSEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSLDSKDCFGLYGEPSEGTTGQAEASCHPEEQKGPNDSSMPQAASGDRAEGHSRLHDSKGQTKLLQLLTTKSDQMEPSPLPSSLSDTNKDSTGSLPGPGSTHGTSLKEKHKILHRLLQDSSSPVDLAKLTAEATGKELSQESSSTAPGSEVTVKQEPASPKKKENALLRYLLDKDDTKDIGLPEITPKLERLDSKTDPASNTKLIAMKTVKEEVSFEPSDQPGSELDNLEEILDDLQNSQLPQLFPDTRPGAPTGSVDKQAIINDLMQLTADSSPVPPAGAQKAALRMSQSTFNNPRPGQLGRLLPNQNLPLDITLQSPTGAGPFPPIRNSSPYSVIPQPGMMGNQGMLGSQGNLGNNSTGMIGSSTSRPSMPSGEWAPQSPAVRVTCAATTGAMNRPVQGGMIRNPTASIPMRANSQPGQRQMLQSQVMNIGPSELEMNMGGPQYNQQQAPPNQTAPWPESILPIDQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALLDQLYLALRNFDGLEEIDRALGIPELVSQSQAVDAEQFSSQESSIMLEQKPPVFPQQYASQAQMAQGGYNPMQDPNFHTMGQRPNYTTLRMQPRPGLRPTGIVQNQPNQLRLQLQHRLQAQQNRQPLMNQISSVSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQMQQQVQQRTLMMRGQGLNVTPSMVAPAGLPAAMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATTPQSPLMSPRMAHTQSPMMQQSQANPAYQPTSDMNGWAQGSMGGNSMFSQQSPPHFGQQANTSMYSNNMNISVSMATNTGGLSSMNQMTGQMSMTSVTSVPTSGLPSMGPEQVNDPALRGGNLFPNQLPGMDMIKQEGDASRKYC
uniprot
proteins
function
FUNCTION: Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:11997499, PubMed:12507421, PubMed:16148126, PubMed:19039140, PubMed:31851938). Coactivator of the steroid binding domain (AF-2) but not of the modulating N-terminal domain (AF-1) (PubMed:11997499, PubMed:12507421, PubMed:16148126, PubMed:19039140). Required with NCOA1 to control energy balance between white and brown adipose tissues (PubMed:11997499, PubMed:12507421, PubMed:16148126, PubMed:19039140). Critical regulator of glucose metabolism regulation, acts as a RORA coactivator to specifically modulate G6PC1 expression (PubMed:11997499, PubMed:12507421, PubMed:16148126, PubMed:19039140). Involved in the positive regulation of the transcriptional activity of the glucocorticoid receptor NR3C1 by sumoylation enhancer RWDD3 (PubMed:11997499, PubMed:12507421, PubMed:16148126, PubMed:19039140). Positively regulates the circadian clock by acting as a transcriptional coactivator for the CLOCK-BMAL1 heterodimer (PubMed:24529706). {ECO:0000269|PubMed:11997499, ECO:0000269|PubMed:12507421, ECO:0000269|PubMed:16148126, ECO:0000269|PubMed:19039140, ECO:0000269|PubMed:24529706, ECO:0000269|PubMed:31851938}.
uniprot
proteins
mass_dalton
158466
uniprot
proteins
mutagenesis
MUTAGEN 644..645; /note="LL->AA: Abolishes interaction with RORC; when associated with 689-A--A-694 and 744-A--A-749."; /evidence="ECO:0000269|PubMed:16148126"; MUTAGEN 689..694; /note="ILHRLL->AAHRAA: Abolishes interaction with RORC; when associated with 644-A-A-645 and 744-A--A-749."; /evidence="ECO:0000269|PubMed:16148126"; MUTAGEN 744..749; /note="LLRYLL->AARAA: Abolishes interaction with RORC; when associated with 644-A-A-645 and 689-A--A-694."; /evidence="ECO:0000269|PubMed:16148126
uniprot
proteins
post_translational_modification
PTM: Acetylated (PubMed:31851938). Deacetylation at Lys-780 by SIRT6 stimulates its ability to coactivate PPARA (PubMed:31851938). {ECO:0000269|PubMed:31851938}.
uniprot
proteins
protein_family
SRC/p160 nuclear receptor coactivator family
uniprot
proteins
pubmed
10381882
uniprot
proteins
pubmed
11997499
uniprot
proteins
pubmed
12477726
uniprot
proteins
pubmed
12507421
uniprot
proteins
pubmed
12709428
uniprot
proteins
pubmed
16148126
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
19039140
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21499262
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24529706
uniprot
proteins
pubmed
31851938
uniprot
proteins
pubmed
8643509
uniprot
proteins
pubmed
9111344
uniprot
proteins
pubmed
9192892
uniprot
proteins
sequence_length
1462
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q15596}.
uniprot
proteins