Cmas
entrez
12764
canonical
uniprot
Q99KK2
canonical
ensembl
ENSMUSG00000030282
resolver
ensp
ENSMUSP00000032419
resolver
enst
ENSMUST00000032419
resolver
genesymbol
Cmas
resolver
uniprot
A0A0R4J0B4
resolver
uniprot
O88719
resolver
uniprot
Q8C330
resolver
uniprot
Q8K2G7
resolver
uniprot_entry
A0A0R4J0B4_MOUSE
resolver
uniprot_entry
NEUA_MOUSE
resolver
uniprot_sec
O88719
resolver
uniprot_sec
Q8C330
resolver
uniprot_sec
Q8K2G7
resolver
amino_acid_sequence
MDALEKGAVTSGPAPRGRPSRGRPPKLQRSRGAGRGLEKPPHLAALVLARGGSKGIPLKNIKRLAGVPLIGWVLRAALDAGVFQSVWVSTDHDEIENVAKQFGAQVHRRSSETSKDSSTSLDAIVEFLNYHNEVDIVGNIQATSPCLHPTDLQKVAEMIREEGYDSVFSVVRRHQFRWSEIQKGVREVTEPLNLNPAKRPRRQDWDGELYENGSFYFAKRHLIEMGYLQGGKMAYYEMRAEHSVDIDVDIDWPIAEQRVLRFGYFGKEKLKEIKLLVCNIDGCLTNGHIYVSGDQKEIISYDVKDAIGISLLKKSGIEVRLISERACSKQTLSALKLDCKTEVSVSDKLATVDEWRKEMGLCWKEVAYLGNEVSDEECLKRVGLSAVPADACSGAQKAVGYICKCSGGRGAIREFAEHIFLLIEKVNNSCQK
uniprot
proteins
ec_number
2.7.7.43
uniprot
proteins
function
FUNCTION: Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN). {ECO:0000269|PubMed:9689047}.
uniprot
proteins
mass_dalton
48058
uniprot
proteins
mutagenesis
MUTAGEN 196; /note="P->A: Does not affect the nuclear localization."; MUTAGEN 198; /note="K->A: Abolishes the nuclear localization but does not affect the enzyme activity; when associated with A-201."; /evidence="ECO:0000269|PubMed:11893746"; MUTAGEN 199; /note="R->A: Abolishes both the nuclear localization and the enzyme activity."; /evidence="ECO:0000269|PubMed:11893746"; MUTAGEN 200; /note="P->A: Does not affect neither the nuclear localization nor the enzyme activity."; /evidence="ECO:0000269|PubMed:11893746"; MUTAGEN 201; /note="R->A: Abolishes the nuclear localization but does not affect the enzyme activity; when associated with A-198."; /evidence="ECO:0000269|PubMed:11893746"; MUTAGEN 202; /note="R->A: Does not strongly affect the nuclear localization but strongly affects the enzyme activity."; /evidence="ECO:0000269|PubMed:11893746"; MUTAGEN 203; /note="Q->A: Does not affect the nuclear localization but affects the enzyme activity."; /evidence="ECO:0000269|PubMed:11893746"; MUTAGEN 204; /note="D->A: Does not affect the nuclear localization."; /evidence="ECO:0000269|PubMed:11893746
uniprot
proteins
pathway_participation
PATHWAY: Amino-sugar metabolism; N-acetylneuraminate metabolism.
uniprot
proteins
protein_family
CMP-NeuNAc synthase family
uniprot
proteins
pubmed
11893746
uniprot
proteins
pubmed
14636592
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
9689047
uniprot
proteins
sequence_length
432
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11893746, ECO:0000269|PubMed:9689047}.
uniprot
proteins