Esp1
entrez
619517
canonical
uniprot
Q3LHH8
canonical
ensembl
ENSMUSG00000073396
resolver
ensp
ENSMUSP00000123886
resolver
enst
ENSMUST00000161110
resolver
genesymbol
Esp1
resolver
genesymbol_syn
Gm6084
resolver
uniprot_entry
ESP1_MOUSE
resolver
amino_acid_sequence
MTSLPVLLFLIILLLPSMITEGRVLTQTGKEATIFADQKTNHEADLKNPDPQEVQRALARILCALGELDKLVKDQANAGQQEFKLPKDFTGRSKCRSLGRIK
uniprot
proteins
function
FUNCTION: Male-specific phermone which is recognized by the Vmn2r116/V2rp5 receptor in the vomeronasal organ (VNO) and enhances female sexual receptive behavior (lordosis) upon male mounting, resulting in successful copulation. {ECO:0000269|PubMed:16208374, ECO:0000269|PubMed:17935991, ECO:0000269|PubMed:20596023, ECO:0000269|PubMed:23576433, ECO:0000269|Ref.3}.
uniprot
proteins
mass_dalton
11346
uniprot
proteins
mutagenesis
MUTAGEN 56; /note="R->E: Reduced neuron activity in the VNO."; /evidence="ECO:0000269|PubMed:23576433"; MUTAGEN 60; /note="R->E: Reduced neuron activity in the VNO."; /evidence="ECO:0000269|PubMed:23576433"; MUTAGEN 63; /note="C->S: No neuron activity in the VNO."; /evidence="ECO:0000269|PubMed:23576433"; MUTAGEN 67; /note="E->R,Q: No neuron activity in the VNO and marked reduction in the accessory olfactory bulb."; /evidence="ECO:0000269|PubMed:23576433"; MUTAGEN 69; /note="D->R: Reduced neuron activity in the VNO."; /evidence="ECO:0000269|PubMed:23576433"; MUTAGEN 70; /note="K->E: Reduced neuron activity in the VNO."; /evidence="ECO:0000269|PubMed:23576433"; MUTAGEN 88; /note="D->R: Reduced neuron activity in the VNO."; /evidence="ECO:0000269|PubMed:23576433"; MUTAGEN 92; /note="R->E: Reduced neuron activity in the VNO."; /evidence="ECO:0000269|PubMed:23576433"; MUTAGEN 95; /note="C->S: No neuron activity in the VNO."; /evidence="ECO:0000269|PubMed:23576433"; MUTAGEN 96; /note="R->E: Reduced neuron activity in the VNO."; /evidence="ECO:0000269|PubMed:23576433
uniprot
proteins
protein_family
Exocrine gland-secreted peptide family
uniprot
proteins
pubmed
16208374
uniprot
proteins
pubmed
17935991
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20596023
uniprot
proteins
pubmed
23576433
uniprot
proteins
sequence_length
102
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16208374, ECO:0000269|PubMed:20596023}. Note=Secreted by the extraorbital lacrimal gland into tears. {ECO:0000269|PubMed:16208374, ECO:0000269|PubMed:20596023}.
uniprot
proteins