Cbx6
entrez
494448
canonical
uniprot
Q9DBY5
canonical
ensembl
ENSMUSG00000089715
resolver
ensp
ENSMUSP00000105255
resolver
enst
ENSMUST00000109627
resolver
genesymbol
Cbx6
resolver
uniprot
Q8BZH5
resolver
uniprot_entry
CBX6_MOUSE
resolver
uniprot_sec
Q8BZH5
resolver
amino_acid_sequence
MELSAVGERVFAAESIIKRRIRKGRIEYLVKWKGWAIKYSTWEPEENILDSRLIAAFEQKERERELYGPKKRGPKPKTFLLKARAQAEALRISDVHFSVKPSASASSPKLHSSAAVHRLKKDIRRCHRMSRRPLPRPDPQGGSPGLRPPISPFSETVRIINRKVKPREPKRNRIILNLKVIDKGPGGGSTAQGTGALARPKVPSRNRVIGKSKKFSESMLRTQIRHMKFGTFALYKPPPAPLAPSTAGKADVASSGPGLLLATPAAAPFDAHSSSSSGCPSPTLQSSDPDDAPPKLLPETLSRSVPNWRESEVLDLSIPPEAAATGQRVPPDVTGAADQALHTALEPTGAGSSEPEAGDWRPEMSPCSNVVVTDVTSNLLTVTIKEFCSPEDFEKVAAGVAGATGGGGGTGPSK
uniprot
proteins
function
FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Possibly contributes to the target selectivity of the PRC1 complex by binding specific regions of chromatin (By similarity). Recruitment to chromatin might occur in an H3K27me3-independent fashion (PubMed:16537902, PubMed:22226355). May have a PRC1-independent function in embryonic stem cells (PubMed:22226355). {ECO:0000250|UniProtKB:O95503, ECO:0000269|PubMed:16537902, ECO:0000269|PubMed:22226355}.
uniprot
proteins
mass_dalton
44460
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Ubiquitination regulates the function of the Polycomb group (PcG) multiprotein PRC1-like complex. Deubiquitinated by USP26. {ECO:0000250|UniProtKB:O95503}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16537902
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22226355
uniprot
proteins
sequence_length
414
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16537902}. Chromosome {ECO:0000269|PubMed:16537902}. Note=Localizes to the inactivated X chromosome in females. {ECO:0000269|PubMed:16537902}.
uniprot
proteins