Sec11c
entrez
66286
canonical
uniprot
Q9D8V7
canonical
ensembl
ENSMUSG00000024516
resolver
ensp
ENSMUSP00000025394
resolver
enst
ENSMUST00000025394
resolver
genesymbol
Sec11c
resolver
genesymbol_syn
Sec11l3
resolver
genesymbol_syn
Spc21
resolver
uniprot_entry
SC11C_MOUSE
resolver
amino_acid_sequence
MVRAGAVGTHLPTSSLDIFGDLRKMNKRQLYYQVLNFAMIVSSALMIWKGLIVLTGSESPIVVVLSGSMEPAFHRGDLLFLTNFREDPIRAGEIVVFKVEGRDIPIVHRVIKVHEKDNGDIKFLTKGDNNEVDDRGLYKEGQNWLEKKDVVGRARGFLPYVGMVTIIMNDYPKFKYALLAVMGAYVLLKRES
uniprot
proteins
ec_number
3.4.21.89
uniprot
proteins
function
FUNCTION: Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids. {ECO:0000250|UniProtKB:Q9BY50}.
uniprot
proteins
mass_dalton
21660
uniprot
proteins
post_translational_modification
PTM: May undergo processing at the N-terminus. {ECO:0000250|UniProtKB:Q9BY50}.
uniprot
proteins
protein_family
Peptidase S26B family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
192
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P13679}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P13679}.
uniprot
proteins
transmembrane_region
TRANSMEM 29..48; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins