Henmt1
entrez
66715
canonical
uniprot
Q8CAE2
canonical
ensembl
ENSMUSG00000045662
resolver
ensp
ENSMUSP00000054829
resolver
ensp
ENSMUSP00000102196
resolver
ensp
ENSMUSP00000143574
resolver
genesymbol
Henmt1
resolver
uniprot
A2VCS5
resolver
uniprot
Q8C3K8
resolver
uniprot_entry
HENMT_MOUSE
resolver
uniprot_sec
A2VCS5
resolver
uniprot_sec
Q8C3K8
resolver
amino_acid_sequence
MEMAESIPCNSVVGGNFKEVSPEKVIRFKPPLYKQRYQFVRDLVDRHEPKKVADLGCGDAKLLKLLKIYPCIQLLVGVDINEEKLHSNGHRLSPYLGEFVKPRDLDLTVTLYHGSVVERDSRLLGFDLITCIELIEHLDSDDLARFPDVVFGYLSPAMVVISTPNAEFNPLFPTVTLRDADHKFEWSRMEFQTWALHVANCYNYRVEFTGVGTPPAGSEHVGYCTQIGVFTKNGGKLSKPSVSQQCDQHVYKPVYTTSYPSLQQEKVLKFVLVGELLIQVDRLRLRYQRMLRDREKDRGPKPGDMDSCPAPHLLLGAVFTEAEKARIESSPKPFCEGEKFYIPLQRLLTYPKLHRLCADEDRVRSLIADSVCLSSDGSAVVVDLHNSWDYRPEEN
uniprot
proteins
ec_number
2.1.1.386
uniprot
proteins
function
FUNCTION: Methyltransferase that adds a 2'-O-methyl group at the 3'-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3'-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis. {ECO:0000269|PubMed:17652135, ECO:0000269|PubMed:18029764}.
uniprot
proteins
mass_dalton
44921
uniprot
proteins
mutagenesis
MUTAGEN 54..58; /note="DLGCG->NAVAV: Abolishes methyltransferase activity."; /evidence="ECO:0000269|PubMed:17652135
uniprot
proteins
protein_family
HEN1 family
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17652135
uniprot
proteins
pubmed
18029764
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
395
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q568P9}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250|UniProtKB:Q568P9}.
uniprot
proteins