Creb3l4
entrez
78284
canonical
uniprot
Q9D2A5
canonical
ensembl
ENSMUSG00000027938
resolver
ensp
ENSMUSP00000029547
resolver
ensp
ENSMUSP00000102992
resolver
genesymbol
Creb3l4
resolver
genesymbol_syn
Atce1
resolver
genesymbol_syn
Jal
resolver
genesymbol_syn
Tisp40
resolver
uniprot
Q9DAE0
resolver
uniprot_entry
CR3L4_MOUSE
resolver
uniprot_sec
Q9DAE0
resolver
amino_acid_sequence
MELGCPELLEPPEDIFSTGSFLELGFNGPASKVPVTRGLQKSEPDDFLNLFIDPNMIHCSETSPGRDSGVSEDPGSPAQQASSSPALYEVVYDSGTLQGTQREAGPTFGLISIQIDQWTPALMVPDACTVSGLPSDSHRHILPRVSTRAPAPPAAMPSCQHHLFLTDEEKQLLAQEGITLPSHLPLTKAEERILKKIRRKIRNKQSAQDSRRRKKEYLDGLESRVAACSEQNQKLQRKVQELERQNIFLMEQVRQLQKLTAQTSSRAAQTSTCVLILLFSLALIILPSFSPFQGQSEARPEDYQLHGVISRNILTHENVTENLESPVLKSKLEELPEAPTTNGSTKTHLKMRVKARPPGQIRGMVHTDEM
uniprot
proteins
function
FUNCTION: Transcriptional activator that may play a role in the unfolded protein response of the testis. Proposed to be involved in spermiogenesis. May be involved in regulating the maturation of sperm head nuclei. Alternatively proposed to be a paternally delivered transcription factor that may function in early zygotic gene activation. Increases the binding of CREM isoform Tau with CRE. The CREM isoform Tau-CREB3L4 heterodimer functions through CRE but not through UPRE and may recruit HIRA to CRE to regulate histone exchange. {ECO:0000269|PubMed:16107712, ECO:0000269|PubMed:16595651, ECO:0000269|PubMed:16925989, ECO:0000269|PubMed:16999736}.
uniprot
proteins
mass_dalton
41025
uniprot
proteins
mutagenesis
MUTAGEN 283; /note="L->P: Lowers translocation to the nucleus."; /evidence="ECO:0000269|PubMed:15938716"; MUTAGEN 311; /note="R->A: Abolishes cleavage by SP1."; /evidence="ECO:0000269|PubMed:15938716
uniprot
proteins
post_translational_modification
PTM: Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region. {ECO:0000269|PubMed:15938716}.
uniprot
proteins
protein_family
ATF subfamily
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
pubmed
11943763
uniprot
proteins
pubmed
11956138
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15938716
uniprot
proteins
pubmed
16107712
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16595651
uniprot
proteins
pubmed
16728718
uniprot
proteins
pubmed
16925989
uniprot
proteins
pubmed
16999736
uniprot
proteins
sequence_length
370
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16925989}; Single-pass type II membrane protein {ECO:0000269|PubMed:16925989}. Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane {ECO:0000269|PubMed:16925989}; Single-pass type II membrane protein {ECO:0000269|PubMed:16925989}. Note=According to PubMed:16925989 is not observed within nuclei of haploid spermatids at any spermiogenic stage.; SUBCELLULAR LOCATION: [Processed cyclic AMP-responsive element-binding protein 3-like protein 4]: Nucleus. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
uniprot
proteins
transmembrane_region
TRANSMEM 272..292; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins