Masp2
entrez
64459
canonical
uniprot
Q9JJS8
canonical
ensembl
ENSRNOG00000011258
resolver
ensp
ENSRNOP00000016317
resolver
enst
ENSRNOT00000016317
resolver
genesymbol
Masp2
resolver
uniprot
A2VCV7
resolver
uniprot
F7FHD3
resolver
uniprot
Q9JJP3
resolver
uniprot
Q9QX83
resolver
uniprot
Q9QX84
resolver
uniprot
Q9QX85
resolver
uniprot
Q9QX86
resolver
uniprot
Q9QX87
resolver
uniprot
Q9QX88
resolver
uniprot
Q9QX89
resolver
uniprot
Q9QX90
resolver
uniprot
Q9QX91
resolver
uniprot
Q9QXD4
resolver
uniprot
Q9WUZ0
resolver
uniprot_entry
A2VCV7_RAT
resolver
uniprot_entry
F7FHD3_RAT
resolver
uniprot_entry
MASP2_RAT
resolver
uniprot_sec
Q9JJP3
resolver
uniprot_sec
Q9QX83
resolver
uniprot_sec
Q9QX84
resolver
uniprot_sec
Q9QX85
resolver
uniprot_sec
Q9QX86
resolver
uniprot_sec
Q9QX87
resolver
uniprot_sec
Q9QX88
resolver
uniprot_sec
Q9QX89
resolver
uniprot_sec
Q9QX90
resolver
uniprot_sec
Q9QX91
resolver
uniprot_sec
Q9QXD4
resolver
uniprot_sec
Q9WUZ0
resolver
amino_acid_sequence
MRLLIVLGLLWSLVATLLGSKWPEPVFGRLVSLGFPEKYGNHQDRSWTLTAPPGFRLRLYFTHFNLELSYRCEYDFVKLTSGTKVLATLCGQESTDTERAPGNDTFYSLGPSLKVTFHSDYSNEKPFTGFEAFYAAEDVDECRTSLGDSVPCDHYCHNYLGGYYCSCRVGYILHQNKHTCSALCSGQVFTGRSGFLSSPEYPQPYPKLSSCAYNIRLEEGFSITLDFVESFDVEMHPEAQCPYDSLKIQTDKREYGPFCGKTLPPRIETDSNKVTITFTTDESGNHTGWKIHYTSTAQPCPDPTAPPNGHISPVQATYVLKDSFSVFCKTGFELLQGSVPLKSFTAVCQKDGSWDRPIPECSIIDCGPPDDLPNGHVDYITGPEVTTYKAVIQYSCEETFYTMSSNGKYVCEADGFWTSSKGEKSLPVCKPVCGLSTHTSGGRIIGGQPAKPGDFPWQVLLLGETTAAGALIHDDWVLTAAHAVYGKTEAMSSLDIRMGILKRLSLIYTQAWPEAVFIHEGYTHGAGFDNDIALIKLKNKVTINRNIMPICLPRKEAASLMKTDFVGTVAGWGLTQKGFLARNLMFVDIPIVDHQKCATAYTKQPYPGAKVTVNMLCAGLDRGGKDSCRGDSGGALVFLDNETQRWFVGGIVSWGSINCGGSEQYGVYTKVTNYIPWIENIINNF
uniprot
proteins
ec_number
3.4.21.104
uniprot
proteins
function
FUNCTION: Precursor of a serum protease that activates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The lectin complement system is activated following association of lectins, such as MBL2, FCN1, FCN2 or FCN3, to carbohydrates on the pathogen surface. MASP2 is cleaved and activated by MASP1 in response to lectin-binding to pathogen carbohydrates. Can activate prothrombin to thrombin. {ECO:0000250|UniProtKB:O00187}.; FUNCTION: [Mannan-binding lectin serine protease 2 B chain]: Serine protease component of the lectin complement pathway, which catalyzes cleavage and activation of C2 and C4, the next components of the complement pathway. {ECO:0000250|UniProtKB:O00187}.
uniprot
proteins
mass_dalton
75667
uniprot
proteins
post_translational_modification
PTM: Activated by cleavage after Arg-443 by MASP1. The uncleaved zymogen is inactive towards synthetic substrates, but has sufficient activity to effect autocatalytic cleavage. {ECO:0000269|PubMed:10586086}.; PTM: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. {ECO:0000269|PubMed:12743029}.; PTM: N-glycosylated. {ECO:0000269|PubMed:10913141, ECO:0000269|PubMed:12743029}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
10092804
uniprot
proteins
pubmed
10586086
uniprot
proteins
pubmed
10913141
uniprot
proteins
pubmed
12743029
uniprot
proteins
pubmed
15672593
uniprot
proteins
pubmed
28111019
uniprot
proteins
sequence_length
685
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10913141}.; SUBCELLULAR LOCATION: [Mannan-binding lectin serine protease 2 B chain]: Secreted {ECO:0000250|UniProtKB:O00187}. Cell surface {ECO:0000250|UniProtKB:O00187}. Note=Recruited to the surface of pathogens by the mannose-binding proteins, such as MBL2. {ECO:0000250|UniProtKB:O00187}.
uniprot
proteins