Arih2
entrez
23807
canonical
uniprot
Q9Z1K6
canonical
ensembl
ENSMUSG00000064145
resolver
ensp
ENSMUSP00000013338
resolver
ensp
ENSMUSP00000289800
resolver
ensp
ENSMUSP00000289807
resolver
ensp
ENSMUSP00000289829
resolver
ensp
ENSMUSP00000333863
resolver
enst
ENSMUST00000013338
resolver
genesymbol
Arih2
resolver
genesymbol_syn
Ari2
resolver
genesymbol_syn
Triad1
resolver
genesymbol_syn
Uip48
resolver
uniprot
Q3TK92
resolver
uniprot_entry
ARI2_MOUSE
resolver
uniprot_entry
Q3TK92_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Autoinhibited by the ariadne domain, which masks the second RING-type zinc finger that contains the active site and inhibits the E3 activity (By similarity). Inhibition is relieved upon binding to neddylated cullin-RING ubiquitin ligase complexes, which activate the E3 ligase activity of ARIH1 (By similarity). {ECO:0000250|UniProtKB:O95376, ECO:0000250|UniProtKB:Q9Y4X5}.
uniprot
proteins
amino_acid_sequence
MSVDMNSQGSDSNEEDYDPNCEEEEEEEEDPGDIEDYYVGVASDVEQQGADAFDPEEYQFTCLTYKESEGALHEHMTSLASVLKVSHSVAKLILVNFHWQVSEILDRYRSNSAQLLVEARVQPNPSKHVPTAHPPHHCAVCMQFVRKENLLSLACQHQFCRSCWEQHCSVLVKDGVGVGISCMAQDCPLRTPEDFVFPLLPNEELRDKYRRYLFRDYVESHFQLQLCPGADCPMVIRVQEPRARRVQCNRCSEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANYISAHTKDCPKCNICIEKNGGCNHMQCSKCKHDFCWMCLGDWKTHGSEYYECSRYKENPDIVNQSQQAQAREALKKYLFYFERWENHNKSLQLEAQTYERIHEKIQERVMNNLGTWIDWQYLQNAAKLLAKCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLEAEIENLSWKVERADSYDRGDLENQMHIAEQRRRTLLKDFHDT
uniprot
proteins
ec_number
2.3.2.31
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (By similarity). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity). The initial ubiquitin is then elongated (By similarity). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex. Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination. May play a role in myelopoiesis (By similarity). {ECO:0000250|UniProtKB:O95376, ECO:0000250|UniProtKB:Q9Y4X5}.
uniprot
proteins
mass_dalton
57697
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Ubiquitination promotes proteasomal degradation. {ECO:0000250|UniProtKB:O95376}.
uniprot
proteins
protein_family
Ariadne subfamily
uniprot
proteins
protein_family
RBR family
uniprot
proteins
pubmed
10431818
uniprot
proteins
pubmed
10880484
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
40355558
uniprot
proteins
sequence_length
492
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:40355558}. Cytoplasm {ECO:0000250|UniProtKB:O95376}.
uniprot
proteins