Socs4
entrez
67296
canonical
uniprot
Q91ZA6
canonical
ensembl
ENSMUSG00000048379
resolver
ensp
ENSMUSP00000066031
resolver
enst
ENSMUST00000065562
resolver
genesymbol
Socs4
resolver
genesymbol_syn
Socs7
resolver
uniprot
Q149F7
resolver
uniprot
Q149F8
resolver
uniprot
Q8C1K3
resolver
uniprot_entry
Q8C1K3_MOUSE
resolver
uniprot_entry
SOCS4_MOUSE
resolver
uniprot_sec
Q149F7
resolver
uniprot_sec
Q149F8
resolver
amino_acid_sequence
MAENNSKNVDVRPKTSRSRSADRKDGYVWSGKKLSWSKKSESCSESEAIGTVENVEIPLRSQERQLSCSSIELDLDHSCGHRFLGRSLKQKLQDAVGQCFPIKNCSGRHSPGLPSKRKIHISELMLDKCPFPPRSDLAFRWHFIKRHTVPMSPNSDEWVSADLSERKLRDAQLKRRNTEDDIPCFSHTNGQPCVITANSASCTGGHITGSMMNLVTNNSIEDSDMDSEDEIITLCTSSRKRNKPRWEMEEEILQLEAPPKFHTQIDYVHCLVPDLLQISNNPCYWGVMDKYAAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYSRSLHARIEQWNHNFSFDAHDPCVFHSPDITGLLEHYKDPSACMFFEPLLSTPLIRTFPFSLQHICRTVICNCTTYDGIDALPIPSPMKLYLKEYHYKSKVRLLRIDVPEQQ
uniprot
proteins
function
FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. Substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits EGF signaling by mediating the degradation of the Tyr-phosphorylated EGF receptor/EGFR (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
49918
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
436
uniprot
proteins