Prxl2a
entrez
361118
canonical
uniprot
Q6AXX6
canonical
ensembl
ENSRNOG00000011140
resolver
ensp
ENSRNOP00000014819
resolver
ensp
ENSRNOP00000078597
resolver
ensp
ENSRNOP00000102558
resolver
enst
ENSRNOT00000014819
resolver
genesymbol
Prxl2a
resolver
genesymbol_syn
Fam213a
resolver
genesymbol_syn
Pamm
resolver
genesymbol_syn
Shp1
resolver
uniprot
A0A8L2Q6Y2
resolver
uniprot
P85300
resolver
uniprot_entry
A0A8L2Q6Y2_RAT
resolver
uniprot_entry
PXL2A_RAT
resolver
uniprot_sec
P85300
resolver
amino_acid_sequence
MSFLQDSSFFSMGMWSIGVGAFGAAALALLLANTDMFLSKPQKAALEYLEDIDLKTLEKEPRTFKAKELWEKNGAVIMAVRRPGCFLCRAEAADLMSLKPKLDELGVPLYAVVKEKVKREVEDFQPYFKGEIFLDEKKKFYGPERRKMMLMGLVRLGVWYNSFRAWKGGFSGNFEGEGFILGGVFVIGSGKQGVLLEHREKEFGDRVNLLSVLEAVKKIKPQTPASRQS
uniprot
proteins
function
FUNCTION: Involved in redox regulation of the cell. Acts as an antioxidant. Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation. May affect bone resorption and help to maintain bone mass. Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway. {ECO:0000250|UniProtKB:Q9BRX8}.
uniprot
proteins
mass_dalton
25763
uniprot
proteins
protein_family
PRXL2A subfamily
uniprot
proteins
protein_family
Peroxiredoxin-like PRXL2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19423663
uniprot
proteins
pubmed
19951071
uniprot
proteins
sequence_length
229
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BRX8}. Secreted {ECO:0000250|UniProtKB:Q9BRX8}. Note=Secreted from mature adipocytes but not from preadipocytes. {ECO:0000250|UniProtKB:Q9BRX8}.
uniprot
proteins