Arfip2
entrez
76932
canonical
uniprot
Q8K221
canonical
ensembl
ENSMUSG00000030881
resolver
ensp
ENSMUSP00000081840
resolver
ensp
ENSMUSP00000120387
resolver
ensp
ENSMUSP00000147995
resolver
enst
ENSMUST00000084782
resolver
enst
ENSMUST00000131446
resolver
enst
ENSMUST00000210911
resolver
genesymbol
Arfip2
resolver
uniprot
A0A1B0GSM3
resolver
uniprot
Q3U3G6
resolver
uniprot
Q9D7M3
resolver
uniprot_entry
A0A1B0GSM3_MOUSE
resolver
uniprot_entry
ARFP2_MOUSE
resolver
uniprot_sec
Q3U3G6
resolver
uniprot_sec
Q9D7M3
resolver
amino_acid_sequence
MTDGILGKAATMEIPIHGNGEAGQLPEDDGLEQDLQQVMVSGPNLNETSIVSGGYGGSGDGLIPTGSGRHPSHSTSPSGPGDEVARGIAGEKFDIVKKWGINTYKCTKQLLSERFGRGSRTVDLELELQIELLRETKRKYESVLQLGRALTAHLYSLLQTQHALGDAFADLSQKSPELQEEFGYNAETQKLLCKNGETLLGAVNFFVSSINTLVTKTMEDTLMTVKQYEAARLEYDAYRTDLEELSLGPRDAGTRGRLESAQATFQTHRDKYEKLRGDVAIKLKFLEENKIKVMHKQLLLFHNAVSAYFAGNQKQLEQTLQQFNIKLRPPGAEKPSWLEEQ
uniprot
proteins
function
FUNCTION: Plays a role in constitutive metalloproteinase (MMP) secretion from the trans Golgi network. May have important functions during vesicle biogenesis at certain cargo subdomains, which could be predominantly utilized by secreted MMPs, such as MMP7 and MMP2. Also involved in autophagy by regulating the starvation-dependent trafficking of ATG9A vesicles which deliver the phosphatidylinositol 4-kinase beta (PI4KB) to the autophagosome initiation site. Involved in phagophore growth during mitophagy by regulating ATG9A trafficking to mitochondria. In addition, plays a role in NF-kappa-B inhibition by interacting with IKBKB and IKBKG. {ECO:0000250|UniProtKB:P53365}.
uniprot
proteins
mass_dalton
37773
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
341
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250|UniProtKB:P53365}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P53365}.
uniprot
proteins