RNF121
entrez
55298
canonical
uniprot
Q9H920
canonical
ensembl
ENSG00000137522
resolver
ensp
ENSP00000354571
resolver
ensp
ENSP00000377316
resolver
ensp
ENSP00000570885
resolver
ensp
ENSP00000616058
resolver
enst
ENST00000393713
resolver
genesymbol
RNF121
resolver
hgnc
HGNC:21070
resolver
uniprot
B3KSW8
resolver
uniprot
C9JQY5
resolver
uniprot
Q6IA57
resolver
uniprot
Q6P449
resolver
uniprot
Q96DB4
resolver
uniprot_entry
C9JQY5_HUMAN
resolver
uniprot_entry
RN121_HUMAN
resolver
uniprot_sec
B3KSW8
resolver
uniprot_sec
Q6IA57
resolver
uniprot_sec
Q6P449
resolver
uniprot_sec
Q96DB4
resolver
amino_acid_sequence
MAAVVEVEVGGGAAGERELDEVDMSDLSPEEQWRVEHARMHAKHRGHEAMHAEMVLILIATLVVAQLLLVQWKQRHPRSYNMVTLFQMWVVPLYFTVKLHWWRFLVIWILFSAVTAFVTFRATRKPLVQTTPRLVYKWFLLIYKISYATGIVGYMAVMFTLFGLNLLFKIKPEDAMDFGISLLFYGLYYGVLERDFAEMCADYMASTIGFYSESGMPTKHLSDSVCAVCGQQIFVDVSEEGIIENTYRLSCNHVFHEFCIRGWCIVGKKQTCPYCKEKVDLKRMFSNPWERPHVMYGQLLDWLRYLVAWQPVIIGVVQGINYILGLE
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase which accepts ubiquitin and transfers it to substrates thereby promoting their degradation by the endoplasmic reticulum-associated degradation (ERAD) pathway which is a pathway involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (By similarity). May regulate the unfolded protein response to reduce endoplasmic reticulum stress (By similarity). {ECO:0000250|UniProtKB:Q09251}.
uniprot
proteins
mass_dalton
37882
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q09251}.
uniprot
proteins
protein_family
RNF121 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
327
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q09251}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 50..70; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 79..99; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 100..120; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 148..168; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 172..192; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 306..326; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins