Cdc26
entrez
66440
canonical
uniprot
Q99JP4
canonical
ensembl
ENSMUSG00000066149
resolver
ensp
ENSMUSP00000081573
resolver
ensp
ENSMUSP00000103083
resolver
ensp
ENSMUSP00000120496
resolver
enst
ENSMUST00000084525
resolver
enst
ENSMUST00000107459
resolver
enst
ENSMUST00000134727
resolver
genesymbol
Cdc26
resolver
uniprot_entry
CDC26_MOUSE
resolver
amino_acid_sequence
MLRRKPTRLELKLDDIEEFESIRKDLEARKKQKEDVEGVGTSDGEGAAGLSSDPKSREQMINDRIGYKPQLKSNNRTSQFGNFEF
uniprot
proteins
function
FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (By similarity). Together with the RING-H2 protein ANAPC11, forms the catalytic component of the E3 ubiquitin ligase complex (By similarity). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (By similarity). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (By similarity). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (By similarity). May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity). {ECO:0000250|UniProtKB:Q8NHZ8}.
uniprot
proteins
mass_dalton
9761
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q8NHZ8}.
uniprot
proteins
protein_family
CDC26 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
85
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins