FBLL1
entrez
345630
canonical
uniprot
A6NHQ2
canonical
ensembl
ENSG00000188573
resolver
ensp
ENSP00000473383
resolver
enst
ENST00000338333
resolver
genesymbol
FBLL1
resolver
hgnc
HGNC:35458
resolver
uniprot
R4GMW7
resolver
uniprot_entry
FBLL1_HUMAN
resolver
uniprot_sec
R4GMW7
resolver
amino_acid_sequence
MKSAASSRGGGGGGRGGGGWGSWGGGRGGGGGAGKGGGGDGGGQGGKGGFGARARGFGGGGRGRGRGGGDGKDRGGGGQRRGGVAKSKSRRRKGAMVVSVEPHRHEGVFIYRGAEDALVTLNMVPGQSVYGERRVTVTEGGVKQEYRTWNPFRSKLAAAILGGVDQIHIKPKSKVLYLGAASGTTVSHVSDIIGPDGLVYAVEFSHRAGRDLVNVAKKRTNIIPVLEDARHPLKYRMLIGMVDVIFADVAQPDQSRIVALNAHTFLRNGGHFLISIKANCIDSTASAEAVFASEVRKLQQENLKPQEQLTLEPYERDHAVVVGVYRPLPKSSSK
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: S-adenosyl-L-methionine-dependent RNA methyltransferase that catalyzes 2'-hydroxyl ribose methylation in RNAs (PubMed:39570315). Functions as part of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes, where guide snoRNAs ensure methylation specificity through base pairing with RNA substrates (PubMed:39570315). Exhibits broad substrate specificity, methylating multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) depending on the guide snoRNA incorporated in the complex (PubMed:39570315). Specifically expressed in brain, it regulates the expression of GAP43 by stabilizing its mRNA through methylation and thereby plays an indirect role in neuronal differentiation (By similarity). {ECO:0000250|UniProtKB:Q80WS3, ECO:0000269|PubMed:39570315}.
uniprot
proteins
mass_dalton
34803
uniprot
proteins
mutagenesis
MUTAGEN 248; /note="D->A: Decreased RNA 2'-O-methyltransferase activity."; /evidence="ECO:0000269|PubMed:39570315
uniprot
proteins
protein_family
Fibrillarin family
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
39570315
uniprot
proteins
sequence_length
334
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:39570315}.
uniprot
proteins