Nkx2-2
entrez
18088
canonical
uniprot
P42586
canonical
ensembl
ENSMUSG00000027434
resolver
ensp
ENSMUSP00000069666
resolver
ensp
ENSMUSP00000105596
resolver
enst
ENSMUST00000067075
resolver
enst
ENSMUST00000109970
resolver
genesymbol
Nkx2-2
resolver
genesymbol_syn
Nkx-2.2
resolver
genesymbol_syn
Nkx2b
resolver
uniprot
F6ZL44
resolver
uniprot
Q3URZ4
resolver
uniprot
Q8BRS9
resolver
uniprot_entry
F6ZL44_MOUSE
resolver
uniprot_entry
NKX22_MOUSE
resolver
uniprot_entry
Q3URZ4_MOUSE
resolver
uniprot_entry
Q8BRS9_MOUSE
resolver
amino_acid_sequence
MSLTNTKTGFSVKDILDLPDTNDEDGSVAEGPEEESEGPEPAKRAGPLGQGALDAVQSLPLKSPFYDSSDNPYTRWLASTEGLQYSLHGLAASAPPQDSSSKSPEPSADESPDNDKETQGGGGDAGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKRARAEKGMEVTPLPSPRRVAVPVLVRDGKPCHALKAQDLAAATFQAGIPFSAYSAQSLQHMQYNAQYSSASTPQYPTAHPLVQAQQWTW
uniprot
proteins
function
FUNCTION: Transcriptional activator involved in the development of insulin-producing beta cells in the endocrine pancreas (PubMed:11076772). May also be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Binds to elements within the NEUROD1 promoter (PubMed:19759004). {ECO:0000269|PubMed:11076772, ECO:0000269|PubMed:19759004}.
uniprot
proteins
mass_dalton
30126
uniprot
proteins
mutagenesis
MUTAGEN 184; /note="K->I: Inhibits DNA-binding activity and transcriptional activation of NEUROD1 expression."; /evidence="ECO:0000269|PubMed:19759004
uniprot
proteins
protein_family
NK-2 homeobox family
uniprot
proteins
pubmed
11076772
uniprot
proteins
pubmed
1346742
uniprot
proteins
pubmed
14573534
uniprot
proteins
pubmed
19759004
uniprot
proteins
pubmed
7939711
uniprot
proteins
pubmed
8654958
uniprot
proteins
sequence_length
273
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:14573534}.
uniprot
proteins