Oxtr
entrez
25342
canonical
uniprot
P70536
canonical
ensembl
ENSRNOG00000005806
resolver
ensembl
ENSRNOG00055006840
resolver
ensembl
ENSRNOG00060012922
resolver
ensembl
ENSRNOG00065027143
resolver
ensp
ENSRNOP00000007724
resolver
ensp
ENSRNOP00055008814
resolver
ensp
ENSRNOP00060017398
resolver
ensp
ENSRNOP00065038357
resolver
enst
ENSRNOT00000007724
resolver
enst
ENSRNOT00055011240
resolver
enst
ENSRNOT00060021981
resolver
enst
ENSRNOT00065046779
resolver
genesymbol
Oxtr
resolver
genesymbol_syn
Otr
resolver
uniprot
Q53ZC5
resolver
uniprot_entry
OXYR_RAT
resolver
uniprot_sec
Q53ZC5
resolver
activity_regulation
ACTIVITY REGULATION: Directly inhibited by progesterone, which prevents oxytocin-binding (PubMed:6313158, PubMed:9548257). Cholesterol and magnesium act as allosteric activators (PubMed:7577971). {ECO:0000269|PubMed:6313158, ECO:0000269|PubMed:7577971, ECO:0000269|PubMed:9548257}.
uniprot
proteins
amino_acid_sequence
MEGTPAANWSVELDLGSGVPPGEEGNRTAGPPQRNEALARVEVAVLCLILFLALSGNACVLLALRTTRHKHSRLFFFMKHLSIADLVVAVFQVLPQLLWDITFRFYGPDLLCRLVKYLQVVGMFASTYLLLLMSLDRCLAICQPLRSLRRRTDRLAVLGTWLGCLVASAPQVHIFSLREVADGVFDCWAVFIQPWGPKAYVTWITLAVYIVPVIVLAACYGLISFKIWQNLRLKTAAAAAAAEGNDAAGGAGRAALARVSSVKLISKAKIRTVKMTFIIVLAFIVCWTPFFFVQMWSVWDVNAPKEASAFIIAMLLASLNSCCNPWIYMLFTGHLFHELVQRFFCCSARYLKGSRPGETSVSKKSNSSTFVLSRRSSSQRSCSQPSSA
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for oxytocin (OXT), a neuropeptide hormone released by the posterior pituitary gland that plays a key role in social behavior and other biological processes, such as milk ejection (PubMed:10497238, PubMed:11606726, PubMed:35104164, PubMed:9548257). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C (PubMed:10497238). OXTR is mainly coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively (PubMed:10497238). In presence of high levels of oxytocin, also coupled to G(i) G proteins, mediating inhibition of adenylate cyclase activity (PubMed:10497238). Central release of oxytocin plays essential roles in social behavior, such as maternal care, social cognition and affiliative behaviors, triggering signaling that modulates neural circuits by altering ion channel activity, changing intrinsic neuronal properties and modifying synaptic transmission (both excitatory and inhibitory) (PubMed:11606726). Peripheral release of oxytocin (secretion into the bloodstream) promotes various processes, such as parturition, lactation or osteoblast differentiation (By similarity). OXTR-mediated signaling promotes milk ejection by triggering and strengthening contraction of the smooth muscle of mammary gland (By similarity). {ECO:0000250|UniProtKB:P30559, ECO:0000269|PubMed:10497238, ECO:0000269|PubMed:11606726, ECO:0000269|PubMed:35104164, ECO:0000269|PubMed:9548257}.
uniprot
proteins
mass_dalton
42869
uniprot
proteins
mutagenesis
MUTAGEN 260; /note="S->A: Decreased long-term social memory."; /evidence="ECO:0000269|PubMed:35104164"; MUTAGEN 337..388; /note="Missing: Reduced G(q)-dependent signaling."; /evidence="ECO:0000269|PubMed:10497238
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-260 by PRKD1 promotes association with G(q) G protein and downstream signaling, enhancing long-term social memory (PubMed:35104164). Phosphorylated by GRK2, GRK3 and/or GRK6 following prolonged stimulation by oxytocin, promoting association with beta-arrestin (ARRB1 or ARRB2), leading to receptor desensitization and negative regulation of G protein-coupled receptor signaling (By similarity). {ECO:0000250|UniProtKB:P30559, ECO:0000269|PubMed:35104164}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Vasopressin/oxytocin receptor subfamily
uniprot
proteins
pubmed
10497238
uniprot
proteins
pubmed
11606726
uniprot
proteins
pubmed
207528
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
35104164
uniprot
proteins
pubmed
6313158
uniprot
proteins
pubmed
7577971
uniprot
proteins
pubmed
7816817
uniprot
proteins
pubmed
9548257
uniprot
proteins
sequence_length
388
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:207528, ECO:0000269|PubMed:7577971}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P30559}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..58; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P30559"; TRANSMEM 77..102; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P30559"; TRANSMEM 109..139; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P30559"; TRANSMEM 154..174; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P30559"; TRANSMEM 200..225; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P30559"; TRANSMEM 272..295; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P30559"; TRANSMEM 308..328; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P30559
uniprot
proteins