Stx11
entrez
74732
canonical
uniprot
Q9D3G5
canonical
ensembl
ENSMUSG00000039232
resolver
ensp
ENSMUSP00000046243
resolver
ensp
ENSMUSP00000132758
resolver
ensp
ENSMUSP00000225293
resolver
ensp
ENSMUSP00000225295
resolver
ensp
ENSMUSP00000225297
resolver
enst
ENSMUST00000042861
resolver
enst
ENSMUST00000163425
resolver
genesymbol
Stx11
resolver
uniprot
F6R0U1
resolver
uniprot
Q3U5V8
resolver
uniprot_entry
F6R0U1_MOUSE
resolver
uniprot_entry
Q3U5V8_MOUSE
resolver
uniprot_entry
STX11_MOUSE
resolver
amino_acid_sequence
MKDRLAELQELSRSYDQQFPDGDNDFDAPREDIVFETDNILESLYRVIQDIQDENQLLLIDVRRLGRQNVRFLTSMRRLSSIKRDTNSIAKAIKTRGEGIHQKLRSMKELSEQAEARHGAHSAVARISHAQYSALARAFQQAMYEYNQAEMKQRDNCKIRIQRQLEIMGKDMSGEQIEDMFEQGKWDVFSENLLADLKGARAALNEIESRHRELLRLEGRIRDVHELFLQMAVLVEKQEDTLNVIELNVQKTLDYTGEAKAQVRKAVQYKKKNPCRTICCFCCPCVN
uniprot
proteins
function
FUNCTION: SNAREs (soluble N-ethylmaleimide-sensitive factor-attachment protein receptors) are essential proteins for intracellular membrane fusion. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four-helix bundle whose assembly releases energy that drives membrane fusion. The core SNARE complex typically consists of four alpha-helical domains, three from target membrane SNAREs (t-SNAREs) and one from a vesicle SNARE (v-SNARE) (PubMed:30811271, PubMed:38198890). Syntaxin-11/STX11 is an atypical lipid-anchored t-SNARE that forms a SNARE complex with the t-SNARE SNAP23 and the v-SNARE VAMP8. This SNARE complex plays a critical role in the regulated exocytosis of cytotoxic granules by natural killer (NK) cells and cytotoxic T-lymphocytes (PubMed:23042080, PubMed:23190531). In macrophages, STX11 regulates stimulus-dependent vesicular transport of TLR4 from recycling endosomes to the plasma membrane by cooperating with SNAP23, thereby playing a critical role in microbial component recognition and the induction of innate and adaptive immunity (PubMed:30811271). In skeletal muscle satellite cells, STX11 cooperates with its cognate SNAREs VAMP4 and SNAP23 to facilitate CD36 vesicular transport from endosomes to the plasma membrane, an essential step in muscle regeneration (PubMed:38198890). In another proposed mechanism, STX11 may function as a regulator of the SNARE VTI1B on late endosomes to regulate trafficking from late endosomes to lysosomes (By similarity). {ECO:0000250|UniProtKB:O75558, ECO:0000269|PubMed:23042080, ECO:0000269|PubMed:23190531, ECO:0000269|PubMed:30811271, ECO:0000269|PubMed:38198890}.
uniprot
proteins
mass_dalton
33369
uniprot
proteins
post_translational_modification
PTM: Palmitoylation by ZDHHC20 releases STX11 from a locked inactive conformation, facilitating the formation of the STX11/SNAP23/VAMP4 SNARE complex and the subsequent fusion of membranes. STX11 is depalmitoylated by ABDHD17A. Palmitoylation and depalmitoylation of STX11 regulate its activity in vesicular transport from endosomes to the plasma membrane (PubMed:38198890). The palmitoylation of STX11 is also responsible for its membrane association and localization to the immunological synapse (By similarity). {ECO:0000250|UniProtKB:O75558, ECO:0000269|PubMed:38198890}.
uniprot
proteins
protein_family
Syntaxin family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23042080
uniprot
proteins
pubmed
23190531
uniprot
proteins
pubmed
30811271
uniprot
proteins
pubmed
38198890
uniprot
proteins
sequence_length
287
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:30811271}; Lipid-anchor {ECO:0000250|UniProtKB:O75558}. Late endosome membrane {ECO:0000250|UniProtKB:O75558}. Note=Palmitoylation participates to membrane anchorage. Localizes at the immunological synapse in activated immune cells. Detected in trans-Golgi network, recycling and late endosomes when overexpressed. {ECO:0000250|UniProtKB:O75558}.
uniprot
proteins