PIH1D1
entrez
55011
canonical
uniprot
Q9NWS0
canonical
ensembl
ENSG00000104872
resolver
ensp
ENSP00000262265
resolver
ensp
ENSP00000675255
resolver
genesymbol
PIH1D1
resolver
genesymbol_syn
NOP17
resolver
hgnc
HGNC:26075
resolver
uniprot
B4DGN7
resolver
uniprot
B4E2X7
resolver
uniprot
Q9BVL0
resolver
uniprot_entry
PIHD1_HUMAN
resolver
uniprot_sec
B4DGN7
resolver
uniprot_sec
B4E2X7
resolver
uniprot_sec
Q9BVL0
resolver
amino_acid_sequence
MANPKLLGMGLSEAEAIGADSARFEELLLQASKELQQAQTTRPESTQIQPQPGFCIKTNSSEGKVFINICHSPSIPPPADVTEEELLQMLEEDQAGFRIPMSLGEPHAELDAKGQGCTAYDVAVNSDFYRRMQNSDFLRELVITIAREGLEDKYNLQLNPEWRMMKNRPFMGSISQQNIRSEQRPRIQELGDLYTPAPGRAESGPEKPHLNLWLEAPDLLLAEVDLPKLDGALGLSLEIGENRLVMGGPQQLYHLDAYIPLQINSHESKAAFHRKRKQLMVAMPLLPVPS
uniprot
proteins
function
FUNCTION: Involved in the assembly of C/D box small nucleolar ribonucleoprotein (snoRNP) particles (PubMed:17636026). Recruits the SWI/SNF complex to the core promoter of rRNA genes and enhances pre-rRNA transcription (PubMed:22368283, PubMed:24036451). Mediates interaction of TELO2 with the R2TP complex which is necessary for the stability of MTOR and SMG1 (PubMed:20864032). Positively regulates the assembly and activity of the mTORC1 complex (PubMed:24036451). {ECO:0000269|PubMed:17636026, ECO:0000269|PubMed:20864032, ECO:0000269|PubMed:22368283, ECO:0000269|PubMed:24036451}.
uniprot
proteins
mass_dalton
32363
uniprot
proteins
mutagenesis
MUTAGEN 54; /note="F->A: Abolishes binding to histone H4."; /evidence="ECO:0000269|PubMed:22368283"; MUTAGEN 55; /note="C->A: No effect on binding to histone H4."; /evidence="ECO:0000269|PubMed:22368283"; MUTAGEN 57; /note="K->A: Abolishes binding to TELO2."; /evidence="ECO:0000269|PubMed:24656813"; MUTAGEN 64; /note="K->A: Abolishes binding to ECD, EFTUD2, RPB1, TELO2 and UBR5."; /evidence="ECO:0000269|PubMed:24656813"; MUTAGEN 113; /note="K->A: Reduces binding to TELO2."; /evidence="ECO:0000269|PubMed:24656813"; MUTAGEN 163; /note="R->A: Reduces binding to TELO2."; /evidence="ECO:0000269|PubMed:24656813"; MUTAGEN 166; /note="K->A: Reduces binding to TELO2."; /evidence="ECO:0000269|PubMed:24656813"; MUTAGEN 168; /note="R->A: Abolishes binding to TELO2."; /evidence="ECO:0000269|PubMed:24656813
uniprot
proteins
protein_family
PIH1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17636026
uniprot
proteins
pubmed
20864032
uniprot
proteins
pubmed
21078300
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22368283
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24036451
uniprot
proteins
pubmed
24656813
uniprot
proteins
pubmed
31738558
uniprot
proteins
sequence_length
290
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9CQJ2}.
uniprot
proteins