Mest
entrez
58827
canonical
uniprot
Q6P5P5
canonical
ensembl
ENSRNOG00000048088
resolver
ensembl
ENSRNOG00055021695
resolver
ensembl
ENSRNOG00060023608
resolver
ensembl
ENSRNOG00065023446
resolver
ensp
ENSRNOP00000065620
resolver
ensp
ENSRNOP00055030262
resolver
ensp
ENSRNOP00060034060
resolver
ensp
ENSRNOP00065032634
resolver
enst
ENSRNOT00000072698
resolver
enst
ENSRNOT00055037175
resolver
enst
ENSRNOT00060041131
resolver
enst
ENSRNOT00065040129
resolver
genesymbol
Mest
resolver
uniprot_entry
MEST_RAT
resolver
amino_acid_sequence
MVRRDRLRRMREWWVQVGLLAVPLLAAYLHIPPPQLSPALHSWKTSGKFFTYKGLRIFYQDSVGVVGSPEIVVLLHGFPTSSYDWYKIWEGLTLRFHRVIALDFLGFGFSDKPRPHQYSIFEQASIVESLLRHLGLQNRRINLLSHDYGDIVAQELLYRYKQNRSGRLTIKSLCLSNGGIFPETHRPLLLQKLLKDGGVLSPILTRLMNFFVFSRGLTPVFGPYTRPTESELWDMWAGIRNNDGNLVIDSLLQYINQRKKFRRRWVGALASVTIPIHFIYGPLDPINPYPEFLELYRKTLPRSTVSILDDHISHYPQLEDPMGFLNAYMGFINSF
uniprot
proteins
ec_number
3.-.-.-
uniprot
proteins
function
FUNCTION: Plays an important role in enabling neurons to transition from bipolar to multipolar shapes, a process essential for their correct migration toward the cortical plate during brain development. This function is likely achieved through the regulation of N-cadherin-dependent cell adhesion and the modulation of Akt and canonical Wnt signaling pathways. Essential for the development and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. Negatively regulates the canonical Wnt signaling pathway during adipogenic differentiation by reducing the glycosylation, maturation, and cell membrane localization of the Wnt coreceptor LRP6. {ECO:0000250|UniProtKB:Q07646}.
uniprot
proteins
mass_dalton
38879
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
335
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q07646}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..33; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 63..83; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 266..286; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins