Kdm1b
entrez
218214
canonical
uniprot
Q8CIG3
canonical
ensembl
ENSMUSG00000038080
resolver
ensp
ENSMUSP00000038373
resolver
ensp
ENSMUSP00000308465
resolver
ensp
ENSMUSP00000308467
resolver
ensp
ENSMUSP00000308469
resolver
genesymbol
Kdm1b
resolver
genesymbol_syn
Aof1
resolver
genesymbol_syn
Lsd2
resolver
uniprot
Q8C5C4
resolver
uniprot
Q8CEC1
resolver
uniprot_entry
KDM1B_MOUSE
resolver
uniprot_sec
Q8C5C4
resolver
uniprot_sec
Q8CEC1
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by tranylcypromine, but not by pargyline, deprenyl or rasagiline (PubMed:19407342). Histone H3K4me1 and H3K4me2 demethylase activity is inhibited by DNA, this inhibition is released in complex with GLYR1 (By similarity). {ECO:0000250|UniProtKB:Q8NB78, ECO:0000269|PubMed:19407342}.
uniprot
proteins
amino_acid_sequence
MAASRGRSKKRSNLELSPDNLPLRSSGRQAKKKAVEIPDEDEDGSSEKKYRKCEKAGCTAAYPVCFASASERCAKNGYTSRWYHLSCGEHFCNECFDHYYRSHKDGYDKYSAWKRVWTSNGKTEPSPKAFMADQQLPYWVQCTKPECGKWRQLTKEIQLTPHMARTYRCGMKPNTITKPDTPDHCSFPEDLRVLEVSNHWWYPMLIQPPLLKDSVAAPLLSAYYPDCVGMSPSCTSTHRATVTAATTTTGSASPGEMEPSKAAPSSLVLGMNRYFQPFYQPNECGKALCVRPDVMELDELYEFPEYSRDPTMYLALRNLILALWYTNCKEALTPQKCIPHIIVRGLVRIRCVQEVERILYFMTRKGLINTGVLTVAAGQHLLPKHYHNKSVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVWDDKSFKGVVVGRGPQIVNGCINNPVALMCEQLGISMRKLGERCDLIQEGGRITDPTVDKRMDFHFNALLDVVSEWRKDKTLLQDVPLGEKIEEIYRAFVKESGIQFSELEGQVLQFHLSNLEYACGSSLHQVSARSWDHNEFFAQFAGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVTTTDGMGHSAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVQGADFFGHVPPSASQRGLFAVFYDMDSQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQEIPEPTKYFVTRWSTEPWIQMAYSFVKTFGSGEAYDIIAEEIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKIAAF
uniprot
proteins
ec_number
1.14.99.66
uniprot
proteins
function
FUNCTION: Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4. {ECO:0000269|PubMed:19407342, ECO:0000269|PubMed:19727073}.; FUNCTION: Histone demethylase that demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Required for de novo DNA methylation of a subset of imprinted genes during oogenesis. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Has no effect on tri-methylated 'Lys-4', mono-, di- or tri-methylated 'Lys-9', mono-, di- or tri-methylated 'Lys-27', mono-, di- or tri-methylated 'Lys-36' of histone H3, or on mono-, di- or tri-methylated 'Lys-20' of histone H4 (PubMed:19407342, PubMed:19727073). Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of GLYR1 to achieve such activity, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes (By similarity). {ECO:0000250|UniProtKB:Q8NB78, ECO:0000269|PubMed:19407342, ECO:0000269|PubMed:19727073}.
uniprot
proteins
mass_dalton
92633
uniprot
proteins
mutagenesis
MUTAGEN 667; /note="K->A: Loss of activity."; /evidence="ECO:0000269|PubMed:19727073
uniprot
proteins
protein_family
Flavin monoamine oxidase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19407342
uniprot
proteins
pubmed
19727073
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
826
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19727073}. Chromosome {ECO:0000250|UniProtKB:Q8NB78}. Note=Found in actively RNAPolII-transcribed gene bodies. {ECO:0000250|UniProtKB:Q8NB78}.
uniprot
proteins