Nrdc
entrez
230598
canonical
uniprot
Q8BHG1
canonical
ensembl
ENSMUSG00000053510
resolver
ensp
ENSMUSP00000068328
resolver
ensp
ENSMUSP00000099797
resolver
ensp
ENSMUSP00000102255
resolver
enst
ENSMUST00000065977
resolver
enst
ENSMUST00000102736
resolver
enst
ENSMUST00000106644
resolver
genesymbol
Nrdc
resolver
genesymbol_syn
Nrd1
resolver
uniprot
A2A9Q2
resolver
uniprot
A6PWC3
resolver
uniprot_entry
A2A9Q2_MOUSE
resolver
uniprot_entry
A6PWC3_MOUSE
resolver
uniprot_entry
NRDC_MOUSE
resolver
amino_acid_sequence
MLRRVAVAAVCVTGRKLRCEAGRELTALGRIEARGLCEESSKPFPTLTMPGRNKAKSTCSCPDLQPNGQDLGESGRLARLGADESEEEGRSFSNVGDPEIIKSPSDPKQYRYIKLQNGLQALLISDLSNVEGKTGNATDEEEEEEEEEEEEDDDDDDDDDDDDEDSGAEIQDDDEEGFDDEEEFDDDDDDEHDDDDLENEENELEELEERVEARKKTTEKQSAAALCVGVGSFADPDDLPGLAHFLEHMVFMGSLKYPDENGFDAFLKKHGGSDNASTDCERTVFQFDVQRKYFKEALDRWAQFFIHPLMIRDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGHPMGKFFWGNAETLKHEPKKNNIDTHARLREFWMRYYSAHYMTLVVQSKETLDTLEKWVTEIFSQIPNNGLPKPNFSHLTDPFDTPAFNKLYRVVPIRKIHALTITWALPPQQQHYRVKPLHYISWLVGHEGKGSILSYLRKKCWALALFGGNGETGFEQNSTYSVFSISITLTDEGYEHFYEVAHTVFQYLKMLQKLGPEKRVFEEIQKIEDNEFHYQEQTDPVEYVENMCENMQLYPRQDFLTGDQLLFEYKPEVIAEALNQLVPQKANLVLLSGANEGRCDLKEKWFGTQYSIEDIENSWTELWKSNFDLNPDLHLPAENKYIATDFTLKAFDCPETEYPAKIVNTAQGCLWYKKDNKFKIPKAYIRFHLISPLIQKSAANVVLFDIFVNILTHNLAEPAYEADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQLIIDYLTEFSSTPAVFTMITEQLKKTYFNILIKPETLAKDVRLLILEYSRWSMIDKYQALMDGLSLDSLLNFVKDFKSQLFVEGLVQGNVTSTESMDFLKYVVDKLNFAPLEREMPVQFQVVELPSGHHLCKVRALNKGDANSEVTVYYQSGTRSLREYTLMELLVMHMEEPCFDFLRTKQTLGYHVYPTCRNTSGILGFSVTVGTQATKYNSETVDKKIEEFLSSFEEKIENLTEDAFNTQVTALIKLKECEDTHLGEEVDRNWNEVVTQQYLFDRLAHEIEALKSFSKSDLVSWFKAHRGPGSKMLSVHVVGYGKYELEEDGAPFGEDSNSREGMQLTYLPPSPVLAESTTPITDIRAFTATLSLFPYHKIVK
uniprot
proteins
ec_number
3.4.24.61
uniprot
proteins
function
FUNCTION: Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination (PubMed:19935654). Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH) (PubMed:28017472). {ECO:0000269|PubMed:19935654, ECO:0000269|PubMed:28017472}.
uniprot
proteins
mass_dalton
132891
uniprot
proteins
protein_family
Peptidase M16 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19935654
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28017472
uniprot
proteins
sequence_length
1161
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:O43847}. Cell projection, dendrite {ECO:0000269|PubMed:19935654}.
uniprot
proteins