SKA3
entrez
221150
canonical
uniprot
Q8IX90
canonical
ensembl
ENSG00000165480
resolver
ensp
ENSP00000319417
resolver
ensp
ENSP00000382896
resolver
ensp
ENSP00000591465
resolver
genesymbol
SKA3
resolver
genesymbol_syn
C13orf3
resolver
genesymbol_syn
RAMA1
resolver
hgnc
HGNC:20262
resolver
uniprot
A2A330
resolver
uniprot
A2A331
resolver
uniprot
B2RBY2
resolver
uniprot
Q5VZV5
resolver
uniprot
Q86WR2
resolver
uniprot
Q8NBG1
resolver
uniprot
Q96D22
resolver
uniprot_entry
SKA3_HUMAN
resolver
uniprot_sec
A2A330
resolver
uniprot_sec
A2A331
resolver
uniprot_sec
B2RBY2
resolver
uniprot_sec
Q5VZV5
resolver
uniprot_sec
Q86WR2
resolver
uniprot_sec
Q8NBG1
resolver
uniprot_sec
Q96D22
resolver
amino_acid_sequence
MDPIRSFCGKLRSLASTLDCETARLQRALDGEESDFEDYPMRILYDLHSEVQTLKDDVNILLDKARLENQEGIDFIKATKVLMEKNSMDIMKIREYFQKYGYSPRVKKNSVHEQEAINSDPELSNCENFQKTDVKDDLSDPPVASSCISEKSPRSPQLSDFGLERYIVSQVLPNPPQAVNNYKEEPVIVTPPTKQSLVKVLKTPKCALKMDDFECVTPKLEHFGISEYTMCLNEDYTMGLKNARNNKSEEAIDTESRLNDNVFATPSPIIQQLEKSDAEYTNSPLVPTFCTPGLKIPSTKNSIALVSTNYPLSKTNSSSNDLEVEDRTSLVLNSDTCFENLTDPSSPTISSYENLLRTPTPPEVTKIPEDILQLLSKYNSNLATPIAIKAVPPSKRFLKHGQNIRDVSNKEN
uniprot
proteins
function
FUNCTION: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:19289083, PubMed:19360002, PubMed:23085020). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083, PubMed:19360002). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). In the complex, it mediates the microtubule-stimulated oligomerization (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). {ECO:0000269|PubMed:19289083, ECO:0000269|PubMed:19360002, ECO:0000269|PubMed:23085020}.
uniprot
proteins
mass_dalton
46359
uniprot
proteins
protein_family
SKA3 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19289083
uniprot
proteins
pubmed
19360002
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20813266
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23085020
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
412
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:19289083, ECO:0000269|PubMed:19360002, ECO:0000269|PubMed:20813266}. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. {ECO:0000269|PubMed:19360002}.
uniprot
proteins