Abcc8
entrez
25559
canonical
uniprot
Q09429
canonical
ensembl
ENSRNOG00000021130
resolver
ensembl
ENSRNOG00055006772
resolver
ensembl
ENSRNOG00060011222
resolver
ensembl
ENSRNOG00065008714
resolver
ensp
ENSRNOP00000028696
resolver
ensp
ENSRNOP00000035010
resolver
genesymbol
Abcc8
resolver
genesymbol_syn
Sur
resolver
genesymbol_syn
Sur1
resolver
genesymbol_syn
sur1
resolver
uniprot
O54989
resolver
uniprot
P70532
resolver
uniprot
Q70X90
resolver
uniprot
Q9EQT0
resolver
uniprot_entry
ABCC8_RAT
resolver
uniprot_entry
Q70X90_RAT
resolver
uniprot_sec
O54989
resolver
uniprot_sec
P70532
resolver
uniprot_sec
Q9EQT0
resolver
activity_regulation
ACTIVITY REGULATION: KATP channels are regulated by cytoplasmic ATP/ADP ratios; ATP inhibits the channel by closing the pore, while ADP activates the channel. Activated by phosphatidylinositol 4,5-biphosphate (PtdIns(4,5)P2). {ECO:0000250|UniProtKB:Q09428}.
uniprot
proteins
amino_acid_sequence
MPLAFCGTENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITFPILFIGWGSQSSKVHIHHSTWLHFPGHNLRWILTFILLFVLVCEIAEGILSDGVTESRHLHLYMPAGMAFMAAITSVVYYHNIETSNFPKLLIALLIYWTLAFITKTIKFVKFYDHAIGFSQLRFCLTGLLVILYGMLLLVEVNVIRVRRYVFFKTPREVKPPEDLQDLGVRFLQPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCLAFDAQARKDTQSQQGARAIWRALCHAFGRRLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENHVFQPKTQFLGVYFVSSQEFLGNAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFCSRVEKTRRKEMTSLRAFAVYTSISIFMNTAIPIAAVLITFVGHVSFFKESDFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREEQCAPREPAPQGQAGKYQAVPLKVVNRKRPAREEVRDLLGPLQRLTPSTDGDADNFCVQIIGGFFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQKVSGAVFWNSSLPDSEGEDPSNPERETAADSDARSRGPVAYASQKPWLLNATVEENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHTNVVFLDDPFSALDVHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVMERKAPEPSQGLPRAMSSRDGLLLDEDEEEEEAAESEEDDNLSSVLHQRAKIPWRACTKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALVLSPAARNCSLSQECALDQSVYAMVFTVLCSLGIALCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLGAVKRIHTLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRGAILEFDKPEKLLSQKDSVFASFVRADK
uniprot
proteins
function
FUNCTION: Regulator subunit of pancreatic ATP-sensitive potassium channel (KATP), playing a major role in the regulation of insulin release. In pancreatic cells, it forms KATP channels with KCNJ11; KCNJ11 forms the channel pore while ABCC8 is required for activation and regulation. {ECO:0000250|UniProtKB:Q09428}.
uniprot
proteins
mass_dalton
177185
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCC family
uniprot
proteins
protein_family
Conjugate transporter (TC 3.A.1.208) subfamily
uniprot
proteins
pubmed
7716547
uniprot
proteins
pubmed
8942641
uniprot
proteins
sequence_length
1582
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q09428}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q09428}.
uniprot
proteins
transmembrane_region
TRANSMEM 31..47; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q09428"; TRANSMEM 73..89; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q09428"; TRANSMEM 107..123; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q09428"; TRANSMEM 137..153; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q09428"; TRANSMEM 170..186; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q09428"; TRANSMEM 304..319; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q09428"; TRANSMEM 357..372; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q09428"; TRANSMEM 439..454; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q09428"; TRANSMEM 461..473; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q09428"; TRANSMEM 542..557; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q09428"; TRANSMEM 577..592; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q09428"; TRANSMEM 1014..1031; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:Q09428"; TRANSMEM 1068..1084; /note="Helical; Name=13"; /evidence="ECO:0000250|UniProtKB:Q09428"; TRANSMEM 1144..1161; /note="Helical; Name=14"; /evidence="ECO:0000250|UniProtKB:Q09428"; TRANSMEM 1163..1175; /note="Helical; Name=15"; /evidence="ECO:0000250|UniProtKB:Q09428"; TRANSMEM 1250..1265; /note="Helical; Name=16"; /evidence="ECO:0000250|UniProtKB:Q09428"; TRANSMEM 1282..1297; /note="Helical; Name=17"; /evidence="ECO:0000250|UniProtKB:Q09428
uniprot
proteins