Rfx3
entrez
19726
canonical
uniprot
P48381
canonical
ensembl
ENSMUSG00000040929
resolver
ensp
ENSMUSP00000038760
resolver
ensp
ENSMUSP00000133461
resolver
ensp
ENSMUSP00000134141
resolver
ensp
ENSMUSP00000239156
resolver
enst
ENSMUST00000046898
resolver
genesymbol
Rfx3
resolver
uniprot
G5E890
resolver
uniprot
Q8BLW2
resolver
uniprot
Q8C0R3
resolver
uniprot
Q8VBY6
resolver
uniprot_entry
G5E890_MOUSE
resolver
uniprot_entry
RFX3_MOUSE
resolver
uniprot_sec
Q8BLW2
resolver
uniprot_sec
Q8C0R3
resolver
uniprot_sec
Q8VBY6
resolver
amino_acid_sequence
MQTSETGSDTGSTVTLQTSVASQAAVPTQVVQQVPVQQQVQQVQTVQQVQHVYPAQVQYVEGSDTVYTNGAIRTTTYPYTETQMYSQNTGGNYFDTQGSSAQVTTVVSSHSMVGTGGIQMGVTGGQLISSSGGTYLIGNSMENSGHSVTHTTRASPATIEMAIETLQKSDGLSTHRSSLLNSHLQWLLDNYETAEGVSLPRSTLYNHYLRHCQEHKLDPVNAASFGKLIRSIFMGLRTRRLGTRGNSKYHYYGIRVKPDSPLNRLQEDMQYMAMRQQPMQQKQRYKPMQKVDGVADGFTGSGQQTGTSVEQTVIAQSQHHQQFLDASRALPEFGEVEISSLPDGTTFEDIKSLQSLYREHCEAILDVVVNLQFSLIEKLWQTFWRYSPSTPADGTTITESSNLSEIESRLPKAKLITLCKHESILKWMCNCDHGMYQALVEILIPDVLRPIPSALTQAIRNFAKSLEGWLSNAMNNIPQRMIQTKVAAVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCDDNMVQRLETDFKMTLQQQSTLEQWAAWLDNVMMQALKPYEGRPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQVTGETPIAVMGEFGDLNAVSPGNLDKDEGSEVESETDEDLDDSSEPRAKREKTELSQAFPVGCMQPVLESAVQPSLLNPLHSEHIVTSTQTIRQCSATGNTYTAV
uniprot
proteins
function
FUNCTION: Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells (PubMed:15121860, PubMed:19671664). Also required for ciliated ependymal cell differentiation (PubMed:16930429). Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells (PubMed:17229940). Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes (By similarity). Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5). Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells. {ECO:0000250|UniProtKB:P48380, ECO:0000269|PubMed:15121860, ECO:0000269|PubMed:16930429, ECO:0000269|PubMed:17229940, ECO:0000269|PubMed:19671664}.
uniprot
proteins
mass_dalton
83512
uniprot
proteins
protein_family
RFX family
uniprot
proteins
pubmed
15121860
uniprot
proteins
pubmed
15229132
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16930429
uniprot
proteins
pubmed
17229940
uniprot
proteins
pubmed
19671664
uniprot
proteins
pubmed
8289803
uniprot
proteins
sequence_length
749
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00858, ECO:0000269|PubMed:19671664}.
uniprot
proteins