Arhgef18
entrez
102098
canonical
uniprot
Q6P9R4
canonical
ensembl
ENSMUSG00000004568
resolver
ensp
ENSMUSP00000004684
resolver
ensp
ENSMUSP00000158969
resolver
genesymbol
Arhgef18
resolver
genesymbol_syn
Kiaa0521
resolver
uniprot
E9QK59
resolver
uniprot
Q6A055
resolver
uniprot
Q8BYA4
resolver
uniprot
Q8K227
resolver
uniprot_entry
ARHGI_MOUSE
resolver
uniprot_sec
E9QK59
resolver
uniprot_sec
Q6A055
resolver
uniprot_sec
Q8BYA4
resolver
uniprot_sec
Q8K227
resolver
amino_acid_sequence
MGSEPKPYAQPLDSAAAASTTKGSCGPRKPENPDFFSTVEDEQEDGFLRHLSESTEDFSLDMGALQGSEYLRDLGLGAPSDLHQSEVIMDPETHRQEARRESSHTSCEGASALPQRRSWERSRSCSGSCRRLSLDASTVDKGACLPRTLASLALNLSGNGQKIWTQGCLPVSGTPAPSSKECSSPEKRLRSKSVPVSCEISCMELASDSDVCTSPVQGLEPPVLECLEKDHVEPEHVLIVQQVLQELRQYHGARQRARMSTSPGGAHSNLTWFEFLSESEDGACKIEKPGKSTRVKRSLSSLRSRVTRQKEKGKSPAHLKDKTQDLPGKRECVNGHQLMRGTFSGHSSCPLCGEPLLNSASLKEHPRTTLLSDGSSPAPSRNVGMTISQKGGLQPTPSPAGSGVRLGPIAGDMDEADSVFLKLKQTADDSLSLTSSNAESVFIEDPYIASLRCEIESDAHEFEAESWSLSVDLAYAKKQKKEVVKRQDVLYELMQTEAHHVRTLKIMLKVYSRALQEELQFSGQAVSRLFPCADDLLDMHSHFLARLKERRQEFLEEGSDRNYVIQKIGDVLVQQFSGETGERMKEKYAVFCSGHNDAVGQYKLLLQQSKKFQNLIKKIGNFSIVRRLGVQECILLVTQRITKYPVLVERIIQNTEAGTEDYKDLSQALSLIKDIISQVDAKVSEYEKDQRLKEIAAKTDQKSSGKLKNGLTFRKEDMLQQRQLHLEGALCWKSTSGRLKDVLAVLLTDVLLLLQEKDQKYVFASVDSKPPVISLQKLIVREVANEEKAMFLISASMQGPEMYEMYTSSKEDRNIWMAHIRRAVESCPDEEEDVFSEAEEKKIAEARTMKLQEFQERLSLKDQLIAQSLLEKQQIYLEMAQLSGLEESAQNRGLFRGGGDPSETLRGEQILRSAMSEIEGIQSLICQRHLGSTSSQVEEGSVSAGLPRRAETFGGYDSVGSPSKGGSFKRKVSNSDLRPQDWQGPASSPDSRPCDNSAPSGCCEESPQAVEMPSTESLPTVLELELVHRVQTLSQLLLSLQAVIAQQDSYVEMQRTAIQEREKQFRLQSTRGNLLLEQERQRNFEKQREERAGVEKLQSQLRQEQQRWERERARQQQELELAGARLQEREGEARQMRQRLDQERTELERQRQAYQHDLERLREAQRAVDRERERLELLRRFKKQNTVPGALPPEVLAEAQPASHPPSFNGDGLEGHSAPAKAPGTQGSAMLHGTGPDNVERPEVARWDSAPPESRPAKSDVPIQLLSATNQIQRQTAVQQQIPTKLAASTKGGKEKGSKSRGSQRWESSASFDLKQQLLLSKFIGKDESASRNRRSLSPVLPAAHGSAPASDPCFPAPSPAPAATPPEAFKFGGTSLPPVSPASSLPTTPLATTDEVSKEDVIFF
uniprot
proteins
function
FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPases. May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. Also acts as a GEF for RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects of LPA and other G protein-coupled receptor agonists on actin stress fiber formation, cell shape change and ROS production. Required for EPB41L4B-mediated regulation of the circumferential actomyosin belt in epithelial cells. {ECO:0000250|UniProtKB:Q6ZSZ5}.
uniprot
proteins
mass_dalton
155982
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29601110
uniprot
proteins
sequence_length
1405
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6ZSZ5}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q6ZSZ5}. Cell membrane {ECO:0000250|UniProtKB:Q6ZSZ5}. Apical cell membrane {ECO:0000250|UniProtKB:Q6ZSZ5}. Note=In unactivated eosinophils, distributed around the cell periphery in the perimembranous region (By similarity). In activated eosinophils, relocates to the tip of the nucleopod, a membrane structure formed during activation when the nucleus moves to one end of the cell, and is also concentrated in membrane protrusions at the opposite end of the cell (By similarity). Localizes to the apical cell membrane in epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q6ZSZ5}.
uniprot
proteins