Rffl
entrez
282844
canonical
uniprot
Q8CIN9
canonical
ensembl
ENSRNOG00000007596
resolver
ensp
ENSRNOP00000045245
resolver
ensp
ENSRNOP00000067950
resolver
ensp
ENSRNOP00000068131
resolver
ensp
ENSRNOP00000108638
resolver
enst
ENSRNOT00000076596
resolver
genesymbol
Rffl
resolver
genesymbol_syn
Rad51d
resolver
uniprot
A0A8L2QZU3
resolver
uniprot
Q6AY29
resolver
uniprot_entry
A0A8L2QZU3_RAT
resolver
uniprot_entry
RFFL_RAT
resolver
uniprot_sec
Q6AY29
resolver
amino_acid_sequence
MWASCCNWFCLDGQPEETPPPQGARTQAYSNPGYSSFPSPTGSEPSCKACGVHFASTTRKQTCLDCKKNFCMTCSSQEGNGPRLCLLCLRFRATAFQREELMKMKVKDLRDYLSLHDISTEMCREKEELVFLVLGQQPVISEADRTRAPTLPQAFPEQQAFLTQPQSSTVPPTSPGLPSSPAQVTSVLAQDQETQQAIGHVSQDHEEPIFLESTARVPPEDETQSVDSEDSFVPGRRASLSDLTHLEDIEGLTVRQLKEILARNFVNYKGCCEKWELMERVTRLYKDQKGLQHLVSGNEDQNGGAVPSGLEENLCKICMDSPIDCVLLECGHMVTCTKCGKRMNECPICRQYVIRAVHVFRS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that regulates several biological processes through the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regulating cell migration through the mTORC2 complex. Also ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regulate apoptosis downstream of death domain receptors. Also negatively regulates the tumor necrosis factor-mediated signaling pathway through targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regulates p53/TP53 through its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regulate p53/TP53 through ubiquitination and degradation of SFN. May also play a role in endocytic recycling. {ECO:0000269|PubMed:12859687}.
uniprot
proteins
mass_dalton
40409
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q8WZ73}.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. {ECO:0000305|PubMed:12859687}.; PTM: Palmitoylated. {ECO:0000269|PubMed:12859687}.; PTM: Undergoes caspase-mediated cleavage upon death-receptor activation, by TNFSF10 for instance. May be mediated by the caspases CASP8 and CASP10 in a negative feedback loop (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
12859687
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
362
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:12859687}. Cell membrane {ECO:0000269|PubMed:12859687}; Peripheral membrane protein {ECO:0000269|PubMed:12859687}. Recycling endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=The FYVE-type zinc finger may mediate phosphatidylinositol phosphate-binding and control subcellular localization.
uniprot
proteins