Gss
entrez
25458
canonical
uniprot
P46413
canonical
ensembl
ENSRNOG00000018964
resolver
ensembl
ENSRNOG00055024424
resolver
ensembl
ENSRNOG00060027817
resolver
ensembl
ENSRNOG00065028249
resolver
ensp
ENSRNOP00000025657
resolver
ensp
ENSRNOP00000107930
resolver
ensp
ENSRNOP00055034233
resolver
ensp
ENSRNOP00060040214
resolver
ensp
ENSRNOP00065039911
resolver
enst
ENSRNOT00000025657
resolver
enst
ENSRNOT00055041997
resolver
enst
ENSRNOT00060048298
resolver
enst
ENSRNOT00065048675
resolver
genesymbol
Gss
resolver
uniprot_entry
GSHB_RAT
resolver
amino_acid_sequence
MATSWGSILQDEKQLEELAQQAIDRALAEGVLLRSAKNPSSSDVVTYAPFTLFPSPVPSTLLEQAYAVQMDFNILVDAVSQNSAFLEQTLSSTIKKDEYTARLFDIYKQVLKEGIAQTVFLGLNRSDYMFQCSADGSKALKQIEINTISASFGGLASRTPAVHRHVLNVLNKTNEASKILSNNPSKGLALGIAKAWELYGSANAVVLLIAQEKERNIFDQRAIENELLDRKIHVIRRRFEDVSERGSLDQNRRLFMEDQEVAVVYFRDGYMPSQYNAQNWEARLLLERSCAAKCPDIATQLAGTKKVQQELSRVGLLEALLPGQPEAVARLRATFAGLYSLDMGEEGDQAVAEALAAPSHFVLKPQREGGGNNFYGEEMVHALEQLKDSEERASYILMEKIEPEPFRNCLLRPGSPAQVVQCISELGIFGVYVRQGTTLVMNKHVGHLLRTKAIEHADGGVAAGVAVLDNPYPV
uniprot
proteins
ec_number
6.3.2.3
uniprot
proteins
function
FUNCTION: Catalyzes the production of glutathione from gamma-glutamylcysteine and glycine in an ATP-dependent manner (PubMed:7862666). Glutathione (gamma-glutamylcysteinylglycine, GSH) is the most abundant intracellular thiol in living aerobic cells and is required for numerous processes including the protection of cells against oxidative damage, amino acid transport, the detoxification of foreign compounds, the maintenance of protein sulfhydryl groups in a reduced state and acts as a cofactor for a number of enzymes (PubMed:7862666). Participates in ophthalmate biosynthesis in hepatocytes (By similarity). {ECO:0000250|UniProtKB:P51855, ECO:0000269|PubMed:7862666, ECO:0000303|PubMed:7862666}.
uniprot
proteins
mass_dalton
52345
uniprot
proteins
pathway_participation
PATHWAY: Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2. {ECO:0000305|PubMed:7862666}.
uniprot
proteins
protein_family
Eukaryotic GSH synthase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7862666
uniprot
proteins
sequence_length
474
uniprot
proteins