S1PR1
entrez
1901
canonical
uniprot
P21453
canonical
ensembl
ENSG00000170989
resolver
ensp
ENSP00000305416
resolver
ensp
ENSP00000497175
resolver
ensp
ENSP00000497478
resolver
ensp
ENSP00000498038
resolver
ensp
ENSP00000546188
resolver
ensp
ENSP00000546189
resolver
ensp
ENSP00000615515
resolver
ensp
ENSP00000615516
resolver
enst
ENST00000305352
resolver
enst
ENST00000475289
resolver
enst
ENST00000648480
resolver
enst
ENST00000649383
resolver
enst
ENST00000876129
resolver
enst
ENST00000876130
resolver
enst
ENST00000945456
resolver
enst
ENST00000945457
resolver
genesymbol
S1PR1
resolver
genesymbol_syn
CHEDG1
resolver
genesymbol_syn
EDG1
resolver
hgnc
HGNC:3165
resolver
uniprot
D3DT66
resolver
uniprot
Q9BYY4
resolver
uniprot
Q9NYN8
resolver
uniprot_entry
S1PR1_HUMAN
resolver
uniprot_sec
D3DT66
resolver
uniprot_sec
Q9BYY4
resolver
uniprot_sec
Q9NYN8
resolver
amino_acid_sequence
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. Required for normal chemotaxis toward sphingosine 1-phosphate. Required for normal embryonic heart development and normal cardiac morphogenesis. Plays an important role in the regulation of sprouting angiogenesis and vascular maturation. Inhibits sprouting angiogenesis to prevent excessive sprouting during blood vessel development. Required for normal egress of mature T-cells from the thymus into the blood stream and into peripheral lymphoid organs. Plays a role in the migration of osteoclast precursor cells, the regulation of bone mineralization and bone homeostasis (By similarity). Plays a role in responses to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine by pulmonary endothelial cells and in the protection against ventilator-induced lung injury. {ECO:0000250, ECO:0000269|PubMed:10982820, ECO:0000269|PubMed:11230698, ECO:0000269|PubMed:11583630, ECO:0000269|PubMed:11604399, ECO:0000269|PubMed:19286607, ECO:0000269|PubMed:22344443, ECO:0000269|PubMed:8626678, ECO:0000269|PubMed:9488656}.
uniprot
proteins
mass_dalton
42811
uniprot
proteins
mutagenesis
MUTAGEN 120; /note="R->A: Drastically reduced affinity for sphingosine 1-phosphate."; /evidence="ECO:0000269|PubMed:10982820"; MUTAGEN 121; /note="E->A: Drastically reduced affinity for sphingosine 1-phosphate."; /evidence="ECO:0000269|PubMed:10982820"; MUTAGEN 121; /note="E->Q: Slight activation of the receptor at maximal ligand concentration."; /evidence="ECO:0000269|PubMed:10982820"; MUTAGEN 169; /note="V->Y: Strongly reduced interaction with CD69."; /evidence="ECO:0000269|PubMed:37039481"; MUTAGEN 180; /note="M->Y: Strongly reduced interaction with CD69."; /evidence="ECO:0000269|PubMed:37039481"; MUTAGEN 210; /note="F->L: Impairs sphingosine 1-phosphate binding and signaling."; /evidence="ECO:0000269|PubMed:22344443"; MUTAGEN 236; /note="T->A: Acts as a dominant negative GPCR and inhibits S1P-induced Rac activation, chemotaxis, and angiogenesis."; /evidence="ECO:0000269|PubMed:11583630"; MUTAGEN 265; /note="F->L: Impairs sphingosine 1-phosphate binding and signaling."; /evidence="ECO:0000269|PubMed:22344443"; MUTAGEN 269; /note="W->F,L: Impairs sphingosine 1-phosphate binding and signaling."; /evidence="ECO:0000269|PubMed:22344443"; MUTAGEN 292; /note="R->A,V: Drastically reduced affinity for sphingosine 1-phosphate."; /evidence="ECO:0000269|PubMed:10982820
uniprot
proteins
post_translational_modification
PTM: S1P-induced endothelial cell migration requires the PKB/AKT1-mediated phosphorylation of the third intracellular loop at the Thr-236 residue. {ECO:0000269|PubMed:11583630, ECO:0000269|PubMed:19286607}.; PTM: Palmitoylated by ZDHHC5. Palmitoylation is required for targeting to plasma membrane, enabling G(i) coupling. {ECO:0000269|PubMed:29185452}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10383399
uniprot
proteins
pubmed
10982820
uniprot
proteins
pubmed
11230698
uniprot
proteins
pubmed
11583630
uniprot
proteins
pubmed
11604399
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15750791
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19286607
uniprot
proteins
pubmed
2160972
uniprot
proteins
pubmed
22344443
uniprot
proteins
pubmed
29185452
uniprot
proteins
pubmed
37039481
uniprot
proteins
pubmed
8626678
uniprot
proteins
pubmed
9409733
uniprot
proteins
pubmed
9488656
uniprot
proteins
sequence_length
382
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29185452}; Multi-pass membrane protein. Endosome. Membrane raft. Note=Recruited to caveolin-enriched plasma membrane microdomains in response to oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine. Ligand binding leads to receptor internalization.
uniprot
proteins
transmembrane_region
TRANSMEM 47..68; /note="Helical; Name=1"; TRANSMEM 83..104; /note="Helical; Name=2"; TRANSMEM 117..138; /note="Helical; Name=3"; TRANSMEM 161..182; /note="Helical; Name=4"; TRANSMEM 197..224; /note="Helical; Name=5"; TRANSMEM 258..278; /note="Helical; Name=6"; TRANSMEM 290..310; /note="Helical; Name=7
uniprot
proteins