CNGA2
entrez
1260
canonical
uniprot
Q16280
canonical
ensembl
ENSG00000183862
resolver
ensp
ENSP00000328478
resolver
enst
ENST00000329903
resolver
genesymbol
CNGA2
resolver
genesymbol_syn
CNCA
resolver
genesymbol_syn
CNCA1
resolver
genesymbol_syn
CNCG2
resolver
hgnc
HGNC:2149
resolver
uniprot
A0AVD0
resolver
uniprot
B3KXY3
resolver
uniprot_entry
B3KXY3_HUMAN
resolver
uniprot_entry
CNGA2_HUMAN
resolver
uniprot_sec
A0AVD0
resolver
amino_acid_sequence
MTEKTNGVKSSPANNHNHHAPPAIKANGKDDHRTSSRPHSAADDDTSSELQRLADVDAPQQGRSGFRRIVRLVGIIREWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDGKGDKDGEDKGTKKKFELFVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADLFIRLRTGFLEQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSPEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYYAISKSIGFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDENEVATSMEVDVQEKLGQLETNMETLYTRFGRLLAEYTGAQQKLKQRITVLETKMKQNNEDDYLSDGMNSPELAAADEP
uniprot
proteins
function
FUNCTION: Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants. Conducts cAMP- and cGMP-gated ion currents, with permeability for monovalent and divalent cations. Also expressed in a subpopulation of sensory neurons of the main olfactory epithelium (type B cells), where it mediates Ca(2+) influx in response to hydrogen sulfide, and is required for defensive behavioral responses to this stimulus (By similarity). {ECO:0000250|UniProtKB:Q00195, ECO:0000250|UniProtKB:Q62398}.
uniprot
proteins
mass_dalton
76048
uniprot
proteins
protein_family
CNGA2 subfamily
uniprot
proteins
protein_family
Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family
uniprot
proteins
pubmed
11764791
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
7532814
uniprot
proteins
sequence_length
664
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q00195}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 145..166; /note="Helical; Name=S1"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 177..197; /note="Helical; Name=S2"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 223..241; /note="Helical; Name=S3"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 247..265; /note="Helical; Name=S4"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 273..296; /note="Helical; Name=S5"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 320..354; /note="Helical; Name=P-helix"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 355..379; /note="Helical; Name=S6"; /evidence="ECO:0000250|UniProtKB:P29973
uniprot
proteins