Jaml
entrez
270152
canonical
uniprot
Q80UL9
canonical
ensembl
ENSMUSG00000048534
resolver
ensp
ENSMUSP00000052033
resolver
ensp
ENSMUSP00000150697
resolver
enst
ENSMUST00000050020
resolver
enst
ENSMUST00000215880
resolver
genesymbol
Jaml
resolver
genesymbol_syn
Amica1
resolver
genesymbol_syn
Gm638
resolver
uniprot
E9QNV7
resolver
uniprot
Q5DTC4
resolver
uniprot_entry
JAML_MOUSE
resolver
uniprot_sec
E9QNV7
resolver
uniprot_sec
Q5DTC4
resolver
amino_acid_sequence
MLCLLKLIVIPVILAPVGYPQGLPGLTVSSPQLRVHVGESVLMGCVVQRTEEKHVDRVDWLFSKDKDDASEYVLFYYSNLSVPTGRFQNRSHLVGDTFHNDGSLLLQDVQKADEGIYTCEIRLKNESMVMKKPVELWVLPEEPKDLRVRVGDTTQMRCSIQSTEEKRVTKVNWMFSSGSHTEEETVLSYDSNMRSGKFQSLGRFRNRVDLTGDISRNDGSIKLQTVKESDQGIYTCSIYVGKLESRKTIVLHVVQDEFQRTISPTPPTDKGQQGILNGNQLVIIVGIVCATFLLLPVLILIVKKAKWNKSSVSSMASVKSLENKEKINPEKHIYSSITTWETTERGISGESEGTYMTMNPVWPSSPKASSLVRSSVRSK
uniprot
proteins
function
FUNCTION: Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR. {ECO:0000269|PubMed:20813954}.
uniprot
proteins
mass_dalton
42533
uniprot
proteins
mutagenesis
MUTAGEN 59; /note="D->A,K,N: Loss of interaction with CXADR."; /evidence="ECO:0000269|PubMed:20813955"; MUTAGEN 72; /note="Y->A: Loss of interaction with CXADR."; /evidence="ECO:0000269|PubMed:20813955"; MUTAGEN 75; /note="F->A,W: Loss of interaction with CXADR."; /evidence="ECO:0000269|PubMed:20813955"; MUTAGEN 77; /note="Y->A,F: Loss of interaction with CXADR."; /evidence="ECO:0000269|PubMed:20813955"; MUTAGEN 122; /note="R->A: Loss of interaction with CXADR."; /evidence="ECO:0000269|PubMed:20813955"; MUTAGEN 334; /note="Y->F: No effect on interaction with PI3 kinase."; /evidence="ECO:0000269|PubMed:20813955"; MUTAGEN 355; /note="Y->F: Loss of interaction with PI3 kinase."; /evidence="ECO:0000269|PubMed:20813955"; MUTAGEN 360..366; /note="PVWPSSP->AVWASSA: Loss of interaction with PI3 kinase."; /evidence="ECO:0000269|PubMed:20813955
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20813954
uniprot
proteins
pubmed
20813955
uniprot
proteins
sequence_length
379
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20813954}; Single-pass type I membrane protein {ECO:0000269|PubMed:20813954}. Cell junction {ECO:0000250|UniProtKB:Q86YT9}. Note=Localized at the plasma membrane and enriched in areas of cell-cell contacts. {ECO:0000250|UniProtKB:Q86YT9}.
uniprot
proteins
transmembrane_region
TRANSMEM 282..302; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins