Gapvd1
entrez
311880
canonical
uniprot
A0A8I5ZT12
canonical
ensembl
ENSRNOG00000017925
resolver
ensembl
ENSRNOG00055006402
resolver
ensembl
ENSRNOG00060021636
resolver
ensembl
ENSRNOG00065026744
resolver
ensp
ENSRNOP00000063504
resolver
ensp
ENSRNOP00000077706
resolver
ensp
ENSRNOP00000082105
resolver
ensp
ENSRNOP00055008079
resolver
ensp
ENSRNOP00060030926
resolver
ensp
ENSRNOP00065037855
resolver
enst
ENSRNOT00000066961
resolver
enst
ENSRNOT00000112773
resolver
enst
ENSRNOT00055010403
resolver
enst
ENSRNOT00060037526
resolver
enst
ENSRNOT00065046136
resolver
genesymbol
Gapvd1
resolver
uniprot
A0A8I5Y674
resolver
uniprot
D4A022
resolver
uniprot_entry
A0A8I5Y674_RAT
resolver
uniprot_entry
D4A022_RAT
resolver
uniprot_entry
GAPD1_RAT
resolver
amino_acid_sequence
MVKLDIHTLAHHLKQERLYVSSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLIITSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSRLRENPRLIASSLVAGEKLNQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFELKESDNPRRLLRRGTCAFSILFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPAQQEKLFGEKGSDRFRQKVQEMVDSNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVGEVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGTEEGDPRTKNSLGKFDKGCVAAFLDVVIGGRAVETPPMSSVNLLEGLSRTVVYISYSQLITLVNFMKSVMSGDQLKEDRMALDNLLANLPQAKPGKSSSLDMTPYSTPQMSPATTPANKKNRLPIGQQLAAITAWDSSATNLTAHIPLVTPFATRSRSRSNMLMDLHMDHEGSSQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQLSDGGQGDVPVDENKLHGKPDKTLRFSLCSDNLEGISEGPSNRSNSVSSLDLEGESVSELGAGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVLGSDFDPNVDEDRLQEIAGAAAENVLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVLPSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPNKIEDLRSECSSDFGGKDSVTSPDVDDIAHGAHQLTSPPSQSESLLAMFDPLSSHEGASAVVRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSHVLTAAEMEAFRQRHSYPERLVRSRSSDIVSCVRRPMSDPSWNRRPGNEELPPAAATGATSLVAAPHSSSSSPSKDSSRGETEERKDSDDERSDRSRPWWRKRFVSAMPKAPIPFRKKEKQEKDKDDLGPDRFSTLTDEPSPRLSAQAQVAEDILDKYRNAIKRTSPSEGALANDESTEVMGDGESAHDSPREELQNMSADDLPDSASQAAHPQDSALSYRDVKKKLRLALCSADSVAFPMLTHSTRNGLPEHTDPEDNEIVCFLKVQIAEAINLQDKSLMAQLQETMRCVCRFDNRTCRKLLASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVANRYFTTVCVRLLLESKEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGAMAQDVIWQNASEEQLQDAQLAIERSVMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEVYLREAPWPSAQSEIRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLSTVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDRK
uniprot
proteins
function
FUNCTION: Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Has GEF activity for RAB5 and GAP activity for RAS (By similarity). May regulate trafficking of NPHS1/Nephrin (By similarity). Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome (By similarity). Involved in podocyte migration (By similarity). {ECO:0000250|UniProtKB:Q14C86, ECO:0000250|UniProtKB:Q6PAR5}.
uniprot
proteins
mass_dalton
165163
uniprot
proteins
protein_family
GAPVD1 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
29959197
uniprot
proteins
sequence_length
1484
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:29959197}. Cell membrane {ECO:0000269|PubMed:29959197}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14C86}. Early endosome {ECO:0000250|UniProtKB:Q14C86}. Note=Recruited to the plasma membrane by TRIP10/CIP4 in response to insulin (By similarity). Association with RAB5 positive endosomes may be transient (By similarity). Partially colocalizes with NPHS1/nephrin in membranes of podocytes (PubMed:29959197). {ECO:0000250|UniProtKB:Q14C86, ECO:0000269|PubMed:29959197}.
uniprot
proteins