Tph1
entrez
24848
canonical
uniprot
P09810
canonical
ensembl
ENSRNOG00000011488
resolver
ensembl
ENSRNOG00055006768
resolver
ensembl
ENSRNOG00060011408
resolver
ensembl
ENSRNOG00065008776
resolver
ensp
ENSRNOP00000052959
resolver
ensp
ENSRNOP00055008671
resolver
ensp
ENSRNOP00060015119
resolver
ensp
ENSRNOP00065010432
resolver
enst
ENSRNOT00000056109
resolver
enst
ENSRNOT00055011087
resolver
enst
ENSRNOT00060019299
resolver
enst
ENSRNOT00065013987
resolver
genesymbol
Tph1
resolver
genesymbol_syn
Tph
resolver
uniprot_entry
TPH1_RAT
resolver
amino_acid_sequence
MIEDNKENKDHSSERGRVTLIFSLKNEVGGLIKALKIFQENHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFPLLKSHTTVLSVDSPDQLPEKEDVMETVPWFPKKISDLDFCANRVLLYGSELDADHPGFKDNVYRRRRKYFAELAMNYKHGDPIPKIEFTEEEIKTWGTIFRELNKLYPTHACREYLRNLPLLSKYCGYREDNVPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEETVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELRHALSGHAKVKPFDPKVACKQECLITSFQDVYFVSESFEDAKEKMREFAKTVKRPFGVKYNPYTQSIQVLRDSKSITSAMNELRHDLDVVNDALARVSRWPSV
uniprot
proteins
ec_number
1.14.16.4
uniprot
proteins
function
FUNCTION: Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis. {ECO:0000269|PubMed:12354109}.
uniprot
proteins
mass_dalton
51068
uniprot
proteins
pathway_participation
PATHWAY: Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2. {ECO:0000269|PubMed:12354109}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, leading to its degradation by the proteasome. Ubiquitinated is triggered by phosphorylation. {ECO:0000269|PubMed:12354109}.; PTM: Phosphorylated; triggering degradation by the proteasome. {ECO:0000269|PubMed:12354109}.
uniprot
proteins
protein_family
Biopterin-dependent aromatic amino acid hydroxylase family
uniprot
proteins
pubmed
12354109
uniprot
proteins
pubmed
1645430
uniprot
proteins
pubmed
2875901
uniprot
proteins
pubmed
3379411
uniprot
proteins
sequence_length
444
uniprot
proteins