Anapc16
entrez
52717
canonical
uniprot
Q9CPV2
canonical
ensembl
ENSMUSG00000020107
resolver
ensp
ENSMUSP00000020307
resolver
ensp
ENSMUSP00000138112
resolver
ensp
ENSMUSP00000138579
resolver
enst
ENSMUST00000020307
resolver
enst
ENSMUST00000182152
resolver
enst
ENSMUST00000182898
resolver
genesymbol
Anapc16
resolver
genesymbol_syn
D10Ertd641e
resolver
uniprot
S4R2B6
resolver
uniprot_entry
APC16_MOUSE
resolver
uniprot_entry
S4R2B6_MOUSE
resolver
amino_acid_sequence
MAASSSSSSAGGVSGSSVTGSGFSVSDLAPPRKALFTYPKGAGEMLEDGSERFLCESVFSYQVASTLKQVKHDQQVARMEKLAGLVEELEADEWRFKPIEQLLGFTPSSG
uniprot
proteins
function
FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (PubMed:20360068). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:20360068). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (By similarity). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (By similarity). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (By similarity). {ECO:0000250|UniProtKB:Q96DE5, ECO:0000269|PubMed:20360068}.
uniprot
proteins
mass_dalton
11667
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:20360068}.
uniprot
proteins
protein_family
APC16 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20360068
uniprot
proteins
sequence_length
110
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20360068}. Nucleus {ECO:0000269|PubMed:20360068}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q96DE5}.
uniprot
proteins