LLGL1
entrez
3996
canonical
uniprot
Q15334
canonical
ensembl
ENSG00000131899
resolver
ensp
ENSP00000321537
resolver
ensp
ENSP00000525664
resolver
ensp
ENSP00000525666
resolver
ensp
ENSP00000525667
resolver
ensp
ENSP00000525668
resolver
ensp
ENSP00000790430
resolver
enst
ENST00000316843
resolver
genesymbol
LLGL1
resolver
genesymbol_syn
DLG4
resolver
genesymbol_syn
HUGL
resolver
genesymbol_syn
HUGL1
resolver
hgnc
HGNC:6628
resolver
uniprot
A7MBM7
resolver
uniprot
O00188
resolver
uniprot
Q58F11
resolver
uniprot
Q86UK6
resolver
uniprot_entry
L2GL1_HUMAN
resolver
uniprot_sec
A7MBM7
resolver
uniprot_sec
O00188
resolver
uniprot_sec
Q58F11
resolver
uniprot_sec
Q86UK6
resolver
amino_acid_sequence
MMKFRFRRQGADPQREKLKQELFAFNKTVEHGFPNQPSALAFDPELRIMAIGTRSGAVKIYGAPGVEFTGLHRDAATVTQMHFLTGQGRLLSLLDDSSLHLWEIVHHNGCAHLEEALSFQLPSRPGFDGASAPLSLTRVTVVLLVAASDIAALGTEGSSVFFLDVTTLTLLEGQTLAPGEVLRSVPDDYRCGKALGPVESLQGHLRDPTKILIGYSRGLLVIWNQASQCVDHIFLGNQQLESLCWGRDSSTVVSSHSDGSYAVWSVDAGSFPTLQPTVATTPYGPFPCKAINKILWRNCESGGHFIIFSGGMPRASYGDRHCVSVLRAETLVTLDFTSRIIDFFTVHSTRPEDEFDDPQALAVLLEEELVVLDLQTPGWPAVPAPYLAPLHSSAITCSAHVASVPAKLWARIVSAGEQQSPQPVSSALSWPITGGRNLAQEPSQRGLLLTGHEDGTVRFWDASGVALRPLYKLSTAGLFQTDCEHADSLAQAAEDDWPPFRKVGCFDPYSDDPRLGVQKVALCKYTAQMVVAGTAGQVLVLELSDVPVEQAVSVAIIDLLQDREGFTWKGHERLSPRTGPLPWPAGFQPRVLVQCLPPAAVTAVTLHTEWSLVAFGTSHGFGLFDYQRKSPVLARCTLHPNDSLAMEGPLSRVKSLKKSLRQSFRRIRKSRVSGKKRAANASSKLQEANAQLAEQACPHDVEMTPVQRRIEPRSADDSLSGVVRCLYFADTFLRDGAHHGPTMWAGTNSGSVFAYALEVPAAAVGGEKRPEQAVEAVLGKEVQLMHRAPVVAIAVLDGRGRPLPEPYEASRDLAQAPDMQGGHAVLIASEEQFKVFTLPKVSAKTKFKLTAHEGCRVRKVALATFASVACEDYAETCLACLTNLGDVHVFSVPGLRPQVHYSCIRKEDISGIASCVFTRHGQGFYLISPSEFERFSLSARNITEPLCSLDINWPRDATQASYRIRESPKLSQANGTPSILLAPQSLDGSPDPAHSMGPDTPEPPEAALSPMSIDSATSADTTLDTTGDVTVEDVKDFLGSSEESEKNLRNLAEDEAHACAILIK
uniprot
proteins
function
FUNCTION: Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane. {ECO:0000269|PubMed:15735678, ECO:0000269|PubMed:16170365}.
uniprot
proteins
mass_dalton
115418
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at least at Ser-663 by PRKCI. {ECO:0000269|PubMed:12725730}.
uniprot
proteins
protein_family
WD repeat L(2)GL family
uniprot
proteins
pubmed
12725730
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15735678
uniprot
proteins
pubmed
16170365
uniprot
proteins
pubmed
20644714
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
7542763
uniprot
proteins
pubmed
8565641
uniprot
proteins
sequence_length
1064
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12725730, ECO:0000269|PubMed:7542763}. Note=Localized to the lateral membrane during the polarization and formation cell-cell contacts. Enriched in developing axons (By similarity). {ECO:0000250}.
uniprot
proteins