Bnip1
entrez
140932
canonical
uniprot
Q8VHI8
canonical
ensembl
ENSRNOG00000020753
resolver
ensp
ENSRNOP00000028173
resolver
enst
ENSRNOT00000028173
resolver
genesymbol
Bnip1
resolver
genesymbol_syn
Sec20l
resolver
uniprot_entry
SEC20_RAT
resolver
amino_acid_sequence
MAAPQDVHVRICNQEIVKFDLEVKALIQDIRDCSGPLSELTELNTKVKEKFQQLKHRIQELEQSAKEQDKESEKQLLLQEVENHKKQMLSNQTSWRKANLTCKLAIDNLEKAELLQGGDSLRQRKTTKESLAQTSSTITESLMGISRMMSQQVQQSEEAMQTLVSSSRTLLDANEEFKSMSGTIQLGRKLITKYNRRELTDKLLIFLALALFLATVLYIVKKRLFPFL
uniprot
proteins
function
FUNCTION: As part of a SNARE complex may be involved in endoplasmic reticulum membranes fusion and be required for the maintenance of endoplasmic reticulum organization. Also plays a role in apoptosis. It is for instance required for endoplasmic reticulum stress-induced apoptosis. As a substrate of RNF185 interacting with SQSTM1, might also be involved in mitochondrial autophagy. {ECO:0000250|UniProtKB:Q12981}.
uniprot
proteins
mass_dalton
26170
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated. 'Lys-63'-linked polyubiquitination by RNF185 increases the interaction with the autophagy receptor SQSTM1. Undergoes 'Lys-29'- and 'Lys-63'-linked polyubiquitination by RNF186 that may regulate BNIP1 localization to the mitochondrion. {ECO:0000250|UniProtKB:Q12981}.
uniprot
proteins
protein_family
SEC20 family
uniprot
proteins
sequence_length
228
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q12981}; Single-pass type IV membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q12981}; Single-pass type IV membrane protein {ECO:0000255}. Note=Localization to the mitochondrion is regulated by RNF186. {ECO:0000250|UniProtKB:Q12981}.
uniprot
proteins
transmembrane_region
TRANSMEM 200..220; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins