SLA
entrez
6503
canonical
uniprot
Q13239
canonical
ensembl
ENSG00000155926
resolver
ensp
ENSP00000337548
resolver
ensp
ENSP00000378759
resolver
ensp
ENSP00000394049
resolver
ensp
ENSP00000427928
resolver
ensp
ENSP00000428559
resolver
genesymbol
SLA
resolver
genesymbol_syn
SLAP
resolver
genesymbol_syn
SLAP1
resolver
hgnc
HGNC:10902
resolver
uniprot
B7Z4J2
resolver
uniprot
B7Z4L6
resolver
uniprot
Q6FI01
resolver
uniprot
Q9UMQ8
resolver
uniprot_entry
SLAP1_HUMAN
resolver
uniprot_sec
B7Z4J2
resolver
uniprot_sec
B7Z4L6
resolver
uniprot_sec
Q6FI01
resolver
uniprot_sec
Q9UMQ8
resolver
amino_acid_sequence
MGNSMKSTPAPAERPLPNPEGLDSDFLAVLSDYPSPDISPPIFRRGEKLRVISDEGGWWKAISLSTGRESYIPGICVARVYHGWLFEGLGRDKAEELLQLPDTKVGSFMIRESETKKGFYSLSVRHRQVKHYRIFRLPNNWYYISPRLTFQCLEDLVNHYSEVADGLCCVLTTPCLTQSTAAPAVRASSSPVTLRQKTVDWRRVSRLQEDPEGTENPLGVDESLFSYGLRESIASYLSLTSEDNTSFDRKKKSISLMYGGSKRKSSFFSSPPYFED
uniprot
proteins
function
FUNCTION: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. {ECO:0000269|PubMed:10449770, ECO:0000269|PubMed:11696592}.
uniprot
proteins
mass_dalton
31156
uniprot
proteins
mutagenesis
MUTAGEN 111; /note="R->K: Strongly reduces interaction with ZAP70, CD3Z, SYK and LAT."; /evidence="ECO:0000269|PubMed:10449770"; MUTAGEN 218; /note="L->S: Abolishes interaction with CBL. Does not affect dimerization; when associated with S-224 and S-229."; /evidence="ECO:0000269|PubMed:10449770"; MUTAGEN 224; /note="L->S: Abolishes interaction with CBL. Does not affect dimerization; when associated with S-218 and S-229."; /evidence="ECO:0000269|PubMed:10449770"; MUTAGEN 229; /note="L->S: Abolishes interaction with CBL. Does not affect dimerization; when associated with S-218 and S-224."; /evidence="ECO:0000269|PubMed:10449770"; MUTAGEN 237..239; /note="LSL->QSQ: Abolishes interaction with CBL. Slightly affects dimerization."; /evidence="ECO:0000269|PubMed:10449770
uniprot
proteins
pubmed
10449770
uniprot
proteins
pubmed
11179692
uniprot
proteins
pubmed
11696592
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8825655
uniprot
proteins
pubmed
9020066
uniprot
proteins
pubmed
9660183
uniprot
proteins
sequence_length
276
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome {ECO:0000250}. Note=Colocalizes with endosomes. {ECO:0000250}.
uniprot
proteins