Cited2
entrez
17684
canonical
uniprot
O35740
canonical
ensembl
ENSMUSG00000039910
resolver
ensp
ENSMUSP00000038405
resolver
genesymbol
Cited2
resolver
genesymbol_syn
Mrg1
resolver
genesymbol_syn
Msg2
resolver
uniprot
O35741
resolver
uniprot
O35742
resolver
uniprot
O35743
resolver
uniprot
O55198
resolver
uniprot
Q6PGA9
resolver
uniprot_entry
CITE2_MOUSE
resolver
uniprot_sec
O35741
resolver
uniprot_sec
O35742
resolver
uniprot_sec
O35743
resolver
uniprot_sec
O55198
resolver
uniprot_sec
Q6PGA9
resolver
amino_acid_sequence
MADHMMAMNHGRFPDGTNGLHHHPAHRMGMGQFPSPHHHQQQQPQHAFNALMGEHIHYGAGNMNATSGIRHAMGPGTVNGGHPPSALAPAARFNNSQFMGPPVASQGGSLPASMQLQKLNNQYFNHHPYPHNHYMPDLHPTAGHQMNGTNQHFRDCNPKHSGGSSTPGGAGGSGTPGGSGGTSGGAGGSSAGGSGGGSTMPASVAHVPAAMLPPNVIDTDFIDEEVLMSLVIEMGLDRIKELPELWLGQNEFDFMTDFVCKQQPSRVSC
uniprot
proteins
function
FUNCTION: Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Also acts as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region. {ECO:0000269|PubMed:10593900, ECO:0000269|PubMed:15475956, ECO:0000269|PubMed:15750185, ECO:0000269|PubMed:16619037, ECO:0000269|PubMed:17537799, ECO:0000269|PubMed:19457926, ECO:0000269|PubMed:21224256}.
uniprot
proteins
mass_dalton
28321
uniprot
proteins
protein_family
CITED family
uniprot
proteins
pubmed
10593900
uniprot
proteins
pubmed
11694877
uniprot
proteins
pubmed
15051727
uniprot
proteins
pubmed
15475956
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15750185
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16619037
uniprot
proteins
pubmed
17537799
uniprot
proteins
pubmed
19457926
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21224256
uniprot
proteins
pubmed
9434189
uniprot
proteins
pubmed
9533950
uniprot
proteins
sequence_length
269
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Note=Colocalizes with EP300 in dot-like structures. {ECO:0000250}.
uniprot
proteins