Plcd1
entrez
18799
canonical
uniprot
Q8R3B1
canonical
ensembl
ENSMUSG00000010660
resolver
ensp
ENSMUSP00000010804
resolver
ensp
ENSMUSP00000149813
resolver
enst
ENSMUST00000010804
resolver
enst
ENSMUST00000214470
resolver
genesymbol
Plcd1
resolver
genesymbol_syn
Plcd
resolver
uniprot
A0A1L1SS92
resolver
uniprot
G5DDB7
resolver
uniprot
Q9Z1B4
resolver
uniprot_entry
A0A1L1SS92_MOUSE
resolver
uniprot_entry
G5DDB7_MOUSE
resolver
uniprot_entry
PLCD1_MOUSE
resolver
uniprot_sec
Q9Z1B4
resolver
amino_acid_sequence
MDSGRDFLTLHGLQDDPDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRSPESQLFSIEDIQEVRMGHRTEGLEKFARDIPEDRCFSIVFKDQRNTLDLIAPSPADVQHWVQGLRKIIDRSGSMDQRQKLQHWIHSCLRKADKNKDNKMNFKEVKDFLKELNVQVDDSYARKIFRECDHSQTDSLEDEEIETFYRMLTQRAEIDRAFAEAAGSAETLSVEKLVTFLQHQQREEEAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGNAFSLAHRRVYQDMNQPLSHYLVSSSHNTYLLEDQLTGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCSLEQQRVMAHHLRAILGPMLLDQPLDGVTTSLPSPEQLKEKILLKGKKLGGLLPAGGENGPEATDVSDEDEAAEMEDEAVRSQVQHKPKEDKLKLVPELSDMVIYCKSVHFGGFSSPSTSGQAFYEMASFSESRALRLLQESGNSFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYLGCFQDNGGCGYVLKPAFLRDPDTTFNSRALTQGPWWAPKKLRVWIISGQQLPKVNKNKNSIVDPKVIVEIHGVGQDVASRQTAVITNNGFNPRWDTEFEFVVAVPDLALVRFMVEDYDSSSKNDFIGQSTIPWNSLKQGYRHVHLLSKNGDLHPSATLFVKISIQD
uniprot
proteins
ec_number
3.1.4.11
uniprot
proteins
function
FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. Essential for trophoblast and placental development. Binds phosphatidylinositol 4,5-bisphosphate (By similarity). {ECO:0000250|UniProtKB:P51178, ECO:0000269|PubMed:16314520}.
uniprot
proteins
mass_dalton
85873
uniprot
proteins
pubmed
10425196
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16314520
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
756
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P51178}; Peripheral membrane protein {ECO:0000250|UniProtKB:P51178}; Cytoplasmic side {ECO:0000250|UniProtKB:P51178}. Cytoplasm {ECO:0000250|UniProtKB:P51178}. Note=The membrane binding is driven by the C2 domain (By similarity). Localized predominantly to the plasma membrane because of the high affinity of the PH domain for PtdIns(4,5)P2. Translocation to the cytosol is a consequence of the higher affinity for Ins(1,4,5)P3 than PtdIns(4,5)P2 and therefore reflects cellular levels of Ins(1,4,5)P3 (By similarity). {ECO:0000250|UniProtKB:P10688, ECO:0000250|UniProtKB:P51178}.
uniprot
proteins