Enpp5
entrez
83965
canonical
uniprot
Q9EQG7
canonical
ensembl
ENSMUSG00000023960
resolver
ensp
ENSMUSP00000024756
resolver
ensp
ENSMUSP00000122767
resolver
ensp
ENSMUSP00000304032
resolver
ensp
ENSMUSP00000304033
resolver
enst
ENSMUST00000024756
resolver
enst
ENSMUST00000154166
resolver
genesymbol
Enpp5
resolver
uniprot
A9C479
resolver
uniprot
Q5FWJ8
resolver
uniprot
Q921P7
resolver
uniprot_entry
ENPP5_MOUSE
resolver
uniprot_entry
Q5FWJ8_MOUSE
resolver
uniprot_sec
A9C479
resolver
uniprot_sec
Q921P7
resolver
amino_acid_sequence
MIPEFLLASCTLATLCHSAPFSLQPEEQKVLVVSFDGFRWDYLYKVPTPHFHYIMKNGVHVNQVTNVFITKTYPNHYTLVTGLFAENHGIVANDMFDPILNKSFSLEHMDIYDSKFWEEATPIWITNQRAGHASGAAMWPGADVKIHDSFPTYYLPYNESVSFEDRVAKIIEWFTAKDPINLGFLYWEEPDDTGHDVGPDSPLMGSVISDVDHKLGYLIKMLKRAKLWNNVNLIVTSDHGMTQCSKQRVIELDRYLDKEHYTLIDHSPVAAILPKEGKFDEVYDALAGAHPNLTVYKKEEIPERWHYKHNDRVQPIVAVADEGWYILQNKSDDFLLGNHGYDNALAEMHPIFLAHGPAFRKNFTKEAMNSTDLYSLLCHLLNLTALPHNGSFWNVQDLLSSATPKPIPYTQSTTLLLGSDKPGEDEQEESYPYYIGVSLGSIIAMVFFVVLIKHLIRSQVHTLQYRQVEVAQPLLQA
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: Can hydrolyze NAD but cannot hydrolyze nucleotide di- and triphosphates (PubMed:28898552). Lacks lysopholipase D activity. May play a role in neuronal cell communication (By similarity). {ECO:0000250|UniProtKB:P84039, ECO:0000269|PubMed:28898552}.
uniprot
proteins
mass_dalton
54387
uniprot
proteins
mutagenesis
MUTAGEN 72; /note="T->A: Catalytically inactive."; /evidence="ECO:0000305|PubMed:28898552"; MUTAGEN 73; /note="Y->F: Can hydrolyze nucleotides, with about fourfold higher rates for adenine versus uridine and no strong preference for diphosphates or triphosphates."; /evidence="ECO:0000269|PubMed:28898552"; MUTAGEN 159; /note="E->S: No effect on its ability to hydrolyze NAD."; /evidence="ECO:0000269|PubMed:28898552
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:P84039}.
uniprot
proteins
protein_family
Nucleotide pyrophosphatase/phosphodiesterase family
uniprot
proteins
pubmed
11027689
uniprot
proteins
pubmed
12927778
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28898552
uniprot
proteins
sequence_length
477
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 432..452; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins