Q01755
uniprot
Q01755
canonical
amino_acid_sequence
MPDVKERAARKEPGAAESASRESRGGNTRESASSARGTDRVGSTVARARPPSPQGPRRGAVKTAPRGPVGHGGLRTGPTSRCPQPSARAKLPSVTRGAPLPPSPGKGHLGGTPSSHRLGMTERVHDASKLDCQLEERSLSSSSLKGKVKDTMPSDFWEHLNEQLSAVPPDFSCALELLKEIKEILLSLLLPRQSRLKNEIEEALDMEFLQQQADRGDLNVSYLSKYILNMMVLLCAPIRDEAVQRLENISDPVRLLRGIFQVLGQMKMDMVNYTIQSLQPQLQEHSVQFERAQFQERLNKEPRLLNHTTKWLTQAATQLIAPSASSSDLQDCSSSAGPSPSDVAVPEPLSPAMVLSQGFLNLLTWDPENEEFPETLVADRPRLQELESQQSQLTILASVLLVASSFSDSGLFSSPQFVDKLKQITKSLVEDFNSRPEEVMQSVSEQVVEEVHQGLESMGLAALSSENTASLVGQLQNIAKKENCVRSVIDQRIHLFLKCCFVLGVQRSLLDLPGGLTLIEAELAELGQKFVSLTHHNQQVFAPYYTEILKTLISPAQTLATKGGSL
uniprot
proteins
function
FUNCTION: Plays a role in the process of sperm capacitation and acrosome reactions (PubMed:9322250, PubMed:9820206). Probable receptor for the putative fertilization-promoting peptide (FPP) at the sperm membrane that may modulate the activity of the adenylyl cyclase cAMP pathway (PubMed:9322250, PubMed:9820206). {ECO:0000269|PubMed:9322250, ECO:0000269|PubMed:9820206}.
uniprot
proteins
mass_dalton
61970
uniprot
proteins
post_translational_modification
PTM: Constitutively phosphorylated on serine, threonine and tyrosine residues within the head and tail regions of noncapacitated spermatozoa (PubMed:27105888). Phosphorylation on tyrosine residues increases upon sperm capacitation within the acrosomal region in a protein kinase A (PKA)-dependent signaling pathway (PubMed:27105888). {ECO:0000269|PubMed:27105888}.
uniprot
proteins
protein_family
TCP11 family
uniprot
proteins
pubmed
1893875
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27105888
uniprot
proteins
pubmed
9322250
uniprot
proteins
pubmed
9820206
uniprot
proteins
sequence_length
566
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:27105888, ECO:0000269|PubMed:9322250}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:27105888, ECO:0000269|PubMed:9322250}. Note=Localizes on the acrosomal cap region of acrosome-intact, but not acrosome-reacted sperm (PubMed:9322250). Colocalizes with MROH2B and PRKACA on the acrosome and tail regions in round spermatids and spermatozoa regardless of the capacitation status of the sperm (PubMed:27105888). {ECO:0000269|PubMed:27105888, ECO:0000269|PubMed:9322250}.
uniprot
proteins
transmembrane_region
TRANSMEM 393..412; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins