Dusp21
entrez
73547
canonical
uniprot
Q9D9D8
canonical
ensembl
ENSMUSG00000025043
resolver
ensp
ENSMUSP00000026018
resolver
enst
ENSMUST00000026018
resolver
genesymbol
Dusp21
resolver
uniprot_entry
DUS21_MOUSE
resolver
amino_acid_sequence
MTTASCIFPSQATQQDNIYGLSQITASLFISNSAVANDKLTLSNNHITTIINVSAEVVNTFFEDIQYVQVPVSDAPNSYLYDFFDPIADHIHGVEMRNGRTLLHCAAGVSRSATLCLAYLMKYHNMTLLDAHTWTKTCRPIIRPNNGFWEQLIHYEFKLFSRNTVRMIYSPIGLIPNIYEKEAYLMELM
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Protein phosphatase component of the sperm flagellar doublet microtubules (PubMed:37295417, PubMed:37989994). May act as a regulator of sperm motility by mediating dephosphorylation of sperm doublet microtubule proteins (PubMed:37295417). Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine (PubMed:18385140). {ECO:0000269|PubMed:18385140, ECO:0000269|PubMed:37295417, ECO:0000269|PubMed:37989994}.
uniprot
proteins
mass_dalton
21509
uniprot
proteins
mutagenesis
MUTAGEN 105; /note="C->A: Abolished protein phosphatase activity."; /evidence="ECO:0000269|PubMed:37295417
uniprot
proteins
protein_family
Non-receptor class dual specificity subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18385140
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
37295417
uniprot
proteins
pubmed
37989994
uniprot
proteins
sequence_length
189
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H596}. Nucleus {ECO:0000250|UniProtKB:Q9H596}. Mitochondrion inner membrane {ECO:0000269|PubMed:18385140}; Peripheral membrane protein {ECO:0000269|PubMed:18385140}; Matrix side {ECO:0000269|PubMed:18385140}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:37295417, ECO:0000269|PubMed:37989994}.
uniprot
proteins