Pabpc1l
entrez
381404
canonical
uniprot
A2A5N3
canonical
ensembl
ENSMUSG00000054582
resolver
ensp
ENSMUSP00000096701
resolver
enst
ENSMUST00000067715
resolver
genesymbol
Pabpc1l
resolver
genesymbol_syn
Epab
resolver
uniprot_entry
PAP1L_MOUSE
resolver
amino_acid_sequence
MDTGGHGCSLSSLYVGDLHPDVTESMLYEMFSPIGNILSIRVCRDVATRRSLGYAYINFQQPADAERALDTMNFEVIKGQPIRIMWSHRDPGLRKSGMGNIFIKNLENSIDNKALYDTFSTFGSILSSKVVYNEHGSRGFGFVHFETHEAAQKAINTMNGMLLNDRKVFVGHFKSRQKREAELGARALGFTNIYVKNLHANVDEQRLQDLFSQFGNMQSVKVMRDSNGQSRGFGFVNFEKHEEAQKAVDHMNGKEVSGQLLYVGRAQKRAERQSELKRRFEQMKQERQNRYQGVNLYVKNLDDSINDERLKEVFSTYGVITSAKVMTESSHSKGFGFVCFSSPEEATKAVTEMNGRIVGTKPLYVALAQRKEERKAILTNQYRRRPSHPVLSSFQQPTSYLLPAVPQSTAQAVYYSSGSITPMQPDPRWTAQPHGPPSTCPPAASVVQPLSTTQHPCIHLRGASQVSSQVPHTQRVVNIGTQTTGPGGEGSSIPGQLLVPHRGTSAVHSAHGVQESAVYVPGHQPLTVSMLAAAPLHEQKQMIGERLYSLIHDACAPLTGKITGMLLELDNLELLLLLESPESLHAKIEEAVAVLQVHREMESTDRN
uniprot
proteins
function
FUNCTION: Poly(A)-binding protein involved in oocyte maturation and early embryo development (PubMed:22621333, PubMed:37052235). It is required for cytosolic mRNA polyadenylation and translational activation of maternally stored mRNA in oocytes (PubMed:22621333). {ECO:0000269|PubMed:22621333, ECO:0000269|PubMed:37052235}.
uniprot
proteins
mass_dalton
67433
uniprot
proteins
mutagenesis
MUTAGEN 97; /note="G->D: Knockin female mice exhibit early embryonic arrest and infertility. MOS expression and activation of the MAPK signaling pathway are abnormally up-regulated in knockin zygotes."; /evidence="ECO:0000269|PubMed:37052235"; MUTAGEN 137; /note="S->F: Knockin female mice exhibit early embryonic arrest and infertility. MOS expression and activation of the MAPK signaling pathway are abnormally up-regulated in knockin zygotes."; /evidence="ECO:0000269|PubMed:37052235"; MUTAGEN 374; /note="R->Q: Knockin female mice exhibit early embryonic arrest and infertility."; /evidence="ECO:0000269|PubMed:37052235
uniprot
proteins
protein_family
Polyadenylate-binding protein type-1 family
uniprot
proteins
pubmed
15630085
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22621333
uniprot
proteins
pubmed
37052235
uniprot
proteins
sequence_length
607
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q4VXU2}.
uniprot
proteins