OR51E2
entrez
81285
canonical
uniprot
Q9H255
canonical
ensembl
ENSG00000167332
resolver
ensp
ENSP00000380153
resolver
ensp
ENSP00000493442
resolver
enst
ENST00000396950
resolver
enst
ENST00000641638
resolver
genesymbol
OR51E2
resolver
genesymbol_syn
PSGR
resolver
hgnc
HGNC:15195
resolver
uniprot
B2RA63
resolver
uniprot
Q6IF94
resolver
uniprot_entry
O51E2_HUMAN
resolver
uniprot_sec
B2RA63
resolver
uniprot_sec
Q6IF94
resolver
amino_acid_sequence
MSSCNFTHATFVLIGIPGLEKAHFWVGFPLLSMYVVAMFGNCIVVFIVRTERSLHAPMYLFLCMLAAIDLALSTSTMPKILALFWFDSREISFEACLTQMFFIHALSAIESTILLAMAFDRYVAICHPLRHAAVLNNTVTAQIGIVAVVRGSLFFFPLPLLIKRLAFCHSNVLSHSYCVHQDVMKLAYADTLPNVVYGLTAILLVMGVDVMFISLSYFLIIRTVLQLPSKSERAKAFGTCVSHIGVVLAFYVPLIGLSVVHRFGNSLHPIVRVVMGDIYLLLPPVINPIIYGAKTKQIRTRVLAMFKISCDKDLQAVGGK
uniprot
proteins
function
FUNCTION: Olfactory receptor activated by short-chain fatty acids (SCFA), such as acetate and propionate (propanoate), and beta-ionone, a synthetic terpenoid odorant (PubMed:19389702, PubMed:27226631, PubMed:29249973, PubMed:36922591). Ligand-binding causes a conformation change that triggers signaling via G(s)-class of G alpha protein GNAL/G(olf), mediating activation of adenylate cyclase activity and increased production of cAMP, initiating a neuronal response that triggers the perception of a smell (PubMed:36922591). Beyond its role in olfaction, may also be activated by steroid hormones and regulate cell proliferation (PubMed:19389702). Stimulation of OR51E2 by beta-ionone affects melanocyte proliferation, differentiation, and melanogenesis (PubMed:27226631). Activation of OR51E2 by beta-ionone increases proliferation and migration of primary retinal pigment epithelial (RPE) cells (PubMed:29249973). In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498). Activated by L-lactate in glomus cells (By similarity). {ECO:0000250|UniProtKB:Q8VBV9, ECO:0000269|PubMed:19389702, ECO:0000269|PubMed:23401498, ECO:0000269|PubMed:27226631, ECO:0000269|PubMed:29249973, ECO:0000269|PubMed:36922591}.
uniprot
proteins
mass_dalton
35493
uniprot
proteins
mutagenesis
MUTAGEN 104; /note="H->A: Decreased activation by propionate."; /evidence="ECO:0000269|PubMed:36922591"; MUTAGEN 158; /note="L->A: Slightly decreased activation by propionate."; /evidence="ECO:0000269|PubMed:36922591"; MUTAGEN 198; /note="G->A: Decreased activation by propionate."; /evidence="ECO:0000269|PubMed:36922591"; MUTAGEN 202; /note="I->A: Decreased activation by propionate."; /evidence="ECO:0000269|PubMed:36922591
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11118034
uniprot
proteins
pubmed
11707321
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14983052
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16491480
uniprot
proteins
pubmed
19389702
uniprot
proteins
pubmed
23401498
uniprot
proteins
pubmed
27226631
uniprot
proteins
pubmed
29249973
uniprot
proteins
pubmed
36922591
uniprot
proteins
sequence_length
320
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23401498, ECO:0000269|PubMed:27226631, ECO:0000269|PubMed:29249973}; Multi-pass membrane protein {ECO:0000269|PubMed:36922591}. Early endosome membrane {ECO:0000269|PubMed:27226631}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 24..49; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:36922591, ECO:0007744|PDB:8F76"; TRANSMEM 60..85; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:36922591, ECO:0007744|PDB:8F76"; TRANSMEM 94..119; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:36922591, ECO:0007744|PDB:8F76"; TRANSMEM 140..164; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:36922591, ECO:0007744|PDB:8F76"; TRANSMEM 192..218; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:36922591, ECO:0007744|PDB:8F76"; TRANSMEM 237..264; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:36922591, ECO:0007744|PDB:8F76"; TRANSMEM 270..295; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:36922591, ECO:0007744|PDB:8F76
uniprot
proteins