Trim31
entrez
224762
canonical
uniprot
Q8R0K2
canonical
ensembl
ENSMUSG00000058063
resolver
ensp
ENSMUSP00000077535
resolver
enst
ENSMUST00000078438
resolver
genesymbol
Trim31
resolver
uniprot_entry
TRI31_MOUSE
resolver
amino_acid_sequence
MAGQPLACQLQEEVTCPICMEILQDPVTIDCGHNFCLQCISQVGKTSEKIQCPLCKLSVNKNTFRPNKLLASLAEKIQSMDPADIQAEKEDSRCQRHKEKLHYFCEQDGAFLCVVCRDSKDHKSHNVTLIDEAAQNYKVQIESQAQDLGQKDKKIIEEKKQGEGAIWAFRAQVDLEKLKIHEEFKLLRQRLDEEESFLLSRLDWLEQQGAKQLRQYVTVTEKQLNSLRKLTKSLKIRLQSSSMELLKDIKDALSRGKEFQFLNPNPVPEDLEKKCSEAKARHESIIKTLTELKDDMNAEGKRDKSAFMNSLNKEEKESWSLLQKNNSVLPTSVPVTLDKSSADPDLTFSQDLKKVTLYIVAGKASNRQAKPRPFYPFHCVRGSPGLSSGRQVWEAEIRGPSGGACIVGVVTELARGAQSQTVSAQSYIWALRISPSGCQPFTNCKAQEYLQVCLKKVGVYVNHDCGEVVFYDAITSKHIYTFQTSFDGKVFPLFGLQVACSHITLSP
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that acts as a regulator of antiviral immune response and inflammation by mediating ubiquitination of substrates (PubMed:27929086, PubMed:27992402). Acts as a regulator of innate immune defense against viruses by mediating 'Lys-63'-linked ubiquitination of MAVS, promoting MAVS polymerization and formation of three-stranded helical filaments on mitochondria (PubMed:27992402). Acts as a negative regulator of the NLRP3 inflammasome by catalyzing 'Lys-48'-linked ubiquitination of NLRP3, leading to its degradation (PubMed:27929086). Regulator of Src-induced anchorage independent cell growth (PubMed:19665990). {ECO:0000269|PubMed:19665990, ECO:0000269|PubMed:27929086, ECO:0000269|PubMed:27992402}.
uniprot
proteins
mass_dalton
57127
uniprot
proteins
mutagenesis
MUTAGEN 52..55; /note="CPLC->APLA: Abolished E3 ubiquitin-protein ligase activity and ability to ubiquitinate MAVS."; /evidence="ECO:0000269|PubMed:27992402
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:27992402}.
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated (in vitro). {ECO:0000250|UniProtKB:Q9BZY9}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19665990
uniprot
proteins
pubmed
27929086
uniprot
proteins
pubmed
27992402
uniprot
proteins
sequence_length
507
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BZY9}. Mitochondrion {ECO:0000250|UniProtKB:Q9BZY9}. Note=Predominantly expressed in the cytoplasm but a fraction is associated with the mitochondria. {ECO:0000250|UniProtKB:Q9BZY9}.
uniprot
proteins