PSMB10
entrez
5699
canonical
uniprot
P40306
canonical
ensembl
ENSG00000205220
resolver
ensp
ENSP00000351314
resolver
enst
ENST00000358514
resolver
genesymbol
PSMB10
resolver
genesymbol_syn
LMP10
resolver
genesymbol_syn
MECL1
resolver
hgnc
HGNC:9538
resolver
uniprot
B2R5J4
resolver
uniprot
Q5U098
resolver
uniprot_entry
PSB10_HUMAN
resolver
uniprot_sec
B2R5J4
resolver
uniprot_sec
Q5U098
resolver
amino_acid_sequence
MLKPALEPRGGFSFENCQRNASLERVLPGLKVPHARKTGTTIAGLVFQDGVILGADTRATNDSVVADKSCEKIHFIAPKIYCCGAGVAADAEMTTRMVASKMELHALSTGREPRVATVTRILRQTLFRYQGHVGASLIVGGVDLTGPQLYGVHPHGSYSRLPFTALGSGQDAALAVLEDRFQPNMTLEAAQGLLVEAVTAGILGDLGSGGNVDACVITKTGAKLLRTLSSPTEPVKRSGRYHFVPGTTAVLTQTVKPLTLELVEETVQAMEVE
uniprot
proteins
disease_involvement
DISEASE: Proteasome-associated autoinflammatory syndrome 5 (PRAAS5) [MIM:619175]: An autosomal recessive, autoinflammatory disorder characterized by recurrent, polymorphic disseminated cutaneous rash with annular lesions, non-specific lymphocytic infiltration in the skin, fever, failure to thrive, and persistent hepatosplenomegaly. Disease onset is in early infancy. {ECO:0000269|PubMed:31783057}. Note=The disease may be caused by variants affecting the gene represented in this entry.; DISEASE: Immunodeficiency 121 with autoinflammation (IMD121) [MIM:620807]: An autosomal dominant immunologic disorder characterized by severe combined immunodeficiency with T- and B-cell lymphopenia and low-normal NK cell numbers, failure to thrive, diarrhea, alopecia, and desquamating erythematous rash. Remaining T cells have limited T-cell receptor repertoires, a skewed memory phenotype, and an elevated CD4/CD8 ratio. Bone marrow examination indicates severely impaired B-cell maturation with limited V(D)J recombination. {ECO:0000269|PubMed:38503300}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.4.25.1
uniprot
proteins
function
FUNCTION: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides.
uniprot
proteins
mass_dalton
28936
uniprot
proteins
post_translational_modification
PTM: Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity. {ECO:0000250|UniProtKB:O35955}.
uniprot
proteins
protein_family
Peptidase T1B family
uniprot
proteins
pubmed
10575004
uniprot
proteins
pubmed
11493458
uniprot
proteins
pubmed
11717192
uniprot
proteins
pubmed
14550573
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15501285
uniprot
proteins
pubmed
15907481
uniprot
proteins
pubmed
17262812
uniprot
proteins
pubmed
18694960
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
31783057
uniprot
proteins
pubmed
38503300
uniprot
proteins
pubmed
8268911
uniprot
proteins
pubmed
8666937
uniprot
proteins
pubmed
9551082
uniprot
proteins
sequence_length
273
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00809}. Nucleus {ECO:0000250}.
uniprot
proteins