Gja1
entrez
14609
canonical
uniprot
P23242
canonical
ensembl
ENSMUSG00000050953
resolver
ensp
ENSMUSP00000064536
resolver
ensp
ENSMUSP00000151620
resolver
ensp
ENSMUSP00000244291
resolver
enst
ENSMUST00000068581
resolver
enst
ENSMUST00000220069
resolver
genesymbol
Gja1
resolver
genesymbol_syn
Cxn-43
resolver
uniprot
Q544I7
resolver
uniprot
Q8C4N2
resolver
uniprot
Q8CE05
resolver
uniprot_entry
CXA1_MOUSE
resolver
uniprot_entry
Q8C4N2_MOUSE
resolver
uniprot_sec
Q544I7
resolver
uniprot_sec
Q8CE05
resolver
amino_acid_sequence
MGDWSALGKLLDKVQAYSTAGGKVWLSVLFIFRILLLGTAVESAWGDEQSAFRCNTQQPGCENVCYDKSFPISHVRFWVLQIIFVSVPTLLYLAHVFYVMRKEEKLNKKEEELKVAQTDGVNVEMHLKQIEIKKFKYGIEEHGKVKMRGGLLRTYIISILFKSVFEVAFLLIQWYIYGFSLSAVYTCKRDPCPHQVDCFLSRPTEKTIFIIFMLVVSLVSLALNIIELFYVFFKGVKDRVKGRSDPYHATTGPLSPSKDCGSPKYAYFNGCSSPTAPLSPMSPPGYKLVTGDRNNSSCRNYNKQASEQNWANYSAEQNRMGQAGSTISNSHAQPFDFPDDSQNAKKVAAGHELQPLAIVDQRPSSRASSRASSRPRPDDLEI
uniprot
proteins
function
FUNCTION: Structural component of the gap junction, a specialized intercellular structure consisting of a cluster of closely packed pairs of transmembrane channels, the connexons, that allow passage of small molecules and electrical signals between neighboring cells. Forms homotypic and heterotypic channels gated by transjunctional voltage (By similarity). May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph (By similarity). Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in the conductive system of ventricular myocardium and heart morphogenesis (PubMed:26403541). May play a role in cell growth inhibition through the regulation of NOV expression and localization (PubMed:15181016). Involved in intercellular innate immune signaling. Mediates translocation of 2',3'-cGAMP and 2',5'-oligoadenylates (2-5A) second messengers from virus-infected cells to macrophages and uninfected neighboring cells to propagate and amplify the antiviral immune response (By similarity). {ECO:0000250|UniProtKB:P08050, ECO:0000250|UniProtKB:P17302, ECO:0000269|PubMed:15181016, ECO:0000269|PubMed:22549838, ECO:0000269|PubMed:26403541}.; FUNCTION: Connexin 43 is possibly the ATP-induced pore of mouse macrophages. {ECO:0000269|PubMed:22549838}.
uniprot
proteins
mass_dalton
43004
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-325, Ser-328 and Ser-330 by CK1 modulates gap junction assembly. Phosphorylated at Ser-368 by PRKCG; phosphorylation induces disassembly of gap junction plaques and inhibition of gap junction activity. Phosphorylation at Ser-368 by PRKCD triggers its internalization into small vesicles leading to proteasome-mediated degradation (By similarity). Phosphorylation by MAPK1/MAPK3 at Ser-279 and Ser-282 leads to increased ubiquitination and lysosomal degradation (PubMed:29959233). {ECO:0000250|UniProtKB:P08050, ECO:0000250|UniProtKB:P17302, ECO:0000250|UniProtKB:Q6TYA7, ECO:0000269|PubMed:29959233}.; PTM: Ubiquitination results in lysosomal degradation. {ECO:0000269|PubMed:29959233}.; PTM: Sumoylated with SUMO1, SUMO2 and SUMO3, which may regulate the level of functional Cx43 gap junctions at the plasma membrane. May be desumoylated by SENP1 or SENP2 (By similarity). {ECO:0000250|UniProtKB:P17302}.; PTM: Acetylated in the developing cortex; leading to delocalization from the cell membrane. {ECO:0000269|PubMed:28507509}.; PTM: S-nitrosylation at Cys-271 is enriched at the muscle endothelial gap junction in arteries, it augments channel permeability and may regulate of smooth muscle cell to endothelial cell communication. {ECO:0000269|PubMed:21071693}.
uniprot
proteins
protein_family
Alpha-type (group II) subfamily
uniprot
proteins
protein_family
Connexin family
uniprot
proteins
pubmed
11741837
uniprot
proteins
pubmed
1318884
uniprot
proteins
pubmed
15181016
uniprot
proteins
pubmed
15213231
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15709751
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1708769
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
18079109
uniprot
proteins
pubmed
19864490
uniprot
proteins
pubmed
2060697
uniprot
proteins
pubmed
20940304
uniprot
proteins
pubmed
21071693
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2178193
uniprot
proteins
pubmed
22549838
uniprot
proteins
pubmed
26085008
uniprot
proteins
pubmed
26403541
uniprot
proteins
pubmed
28507509
uniprot
proteins
pubmed
29959233
uniprot
proteins
pubmed
8395450
uniprot
proteins
sequence_length
382
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26403541, ECO:0000269|PubMed:28507509}; Multi-pass membrane protein {ECO:0000255}. Cell junction, gap junction {ECO:0000250|UniProtKB:P17302}. Endoplasmic reticulum {ECO:0000269|PubMed:18079109, ECO:0000269|PubMed:20940304}. Cell junction {ECO:0000269|PubMed:26403541, ECO:0000269|PubMed:29959233}. Note=Localizes at the intercalated disk (ICD) between two adjacent cardiomyocytes and proper localization at ICD is dependent on TMEM65. {ECO:0000269|PubMed:26403541, ECO:0000269|PubMed:29959233}.
uniprot
proteins
transmembrane_region
TRANSMEM 24..44; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 77..97; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 156..176; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 208..228; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins