Dlg1
entrez
13383
canonical
uniprot
Q811D0
canonical
ensembl
ENSMUSG00000022770
resolver
ensp
ENSMUSP00000023454
resolver
ensp
ENSMUSP00000064280
resolver
ensp
ENSMUSP00000097581
resolver
ensp
ENSMUSP00000110850
resolver
ensp
ENSMUSP00000110855
resolver
ensp
ENSMUSP00000110859
resolver
ensp
ENSMUSP00000280187
resolver
ensp
ENSMUSP00000280188
resolver
ensp
ENSMUSP00000280189
resolver
ensp
ENSMUSP00000280190
resolver
ensp
ENSMUSP00000280191
resolver
ensp
ENSMUSP00000280193
resolver
ensp
ENSMUSP00000280205
resolver
ensp
ENSMUSP00000280206
resolver
ensp
ENSMUSP00000325657
resolver
enst
ENSMUST00000023454
resolver
enst
ENSMUST00000115196
resolver
enst
ENSMUST00000115201
resolver
genesymbol
Dlg1
resolver
genesymbol_syn
Dlgh1
resolver
uniprot
D3Z3B8
resolver
uniprot
E9Q9H0
resolver
uniprot
H7BWY4
resolver
uniprot
Q3UP61
resolver
uniprot
Q62402
resolver
uniprot
Q6PGB5
resolver
uniprot
Q8CGN7
resolver
uniprot_entry
D3Z3B8_MOUSE
resolver
uniprot_entry
DLG1_MOUSE
resolver
uniprot_entry
E9Q9H0_MOUSE
resolver
uniprot_entry
H7BWY4_MOUSE
resolver
uniprot_entry
Q3UP61_MOUSE
resolver
uniprot_sec
Q62402
resolver
uniprot_sec
Q6PGB5
resolver
uniprot_sec
Q8CGN7
resolver
amino_acid_sequence
MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTLLDNPKCVDHSKQCEPVQPVTTWEIASLPSTAVTSETLPGSLSPPVEKYRYQDEEVLPPEHISPQVTNEVLGPELVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVPPSSPIVPVTPALPVPAESTVVLPSAPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEADVRDVTHSKAVEALKEAGSIVRLYVKRRKPASEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNSVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYINDGYAPPDITNSSSQSVDNHVSPSSCLGQTPTSPARYSPISKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSVSSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLNFRFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRGDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRVNDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVRAVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGPYIWVPAKEKL
uniprot
proteins
function
FUNCTION: Essential multidomain scaffolding protein required for normal development (PubMed:11238884). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). May also play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels (By similarity). Functional regulator of Kv1.5 channel (By similarity). During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497). {ECO:0000250, ECO:0000250|UniProtKB:A0A8C0TYJ0, ECO:0000269|PubMed:11238884, ECO:0000269|PubMed:23676497}.
uniprot
proteins
mass_dalton
100120
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MAPK12 (By similarity). Phosphorylation of Ser-232 regulates association with GRIN2A (By similarity). {ECO:0000250|UniProtKB:Q12959, ECO:0000250|UniProtKB:Q62696}.; PTM: Ubiquitinated; by MARCHF2 which results in its degradation. {ECO:0000250|UniProtKB:Q12959}.
uniprot
proteins
protein_family
MAGUK family
uniprot
proteins
pubmed
11238884
uniprot
proteins
pubmed
14988405
uniprot
proteins
pubmed
15277200
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16519681
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23676497
uniprot
proteins
pubmed
25558062
uniprot
proteins
pubmed
8638125
uniprot
proteins
pubmed
8922391
uniprot
proteins
pubmed
9434093
uniprot
proteins
sequence_length
905
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q62696}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q12959}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q62696}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q62696}. Postsynaptic density {ECO:0000250|UniProtKB:Q62696}. Synapse {ECO:0000250|UniProtKB:Q62696}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q62696}. Cell junction {ECO:0000250|UniProtKB:Q12959}. Cytoplasm {ECO:0000250|UniProtKB:Q12959}. Apical cell membrane {ECO:0000250|UniProtKB:Q12959}. Note=Colocalizes with EPB41 at regions of intercellular contacts. Basolateral in epithelial cells. May also associate with endoplasmic reticulum membranes. Mainly found in neurons soma, moderately found at postsynaptic densities. {ECO:0000250|UniProtKB:Q12959, ECO:0000250|UniProtKB:Q62696}.
uniprot
proteins