TYW2
entrez
55039
canonical
uniprot
Q53H54
canonical
ensembl
ENSG00000183665
resolver
ensp
ENSP00000329858
resolver
enst
ENST00000328599
resolver
genesymbol
TYW2
resolver
genesymbol_syn
TRM12
resolver
genesymbol_syn
TRMT12
resolver
hgnc
HGNC:26091
resolver
uniprot
Q6PKB9
resolver
uniprot
Q96F21
resolver
uniprot
Q9NWK6
resolver
uniprot_entry
TYW2_HUMAN
resolver
uniprot_sec
Q6PKB9
resolver
uniprot_sec
Q96F21
resolver
uniprot_sec
Q9NWK6
resolver
amino_acid_sequence
MRENVVVSNMERESGKPVAVVAVVTEPWFTQRYREYLQRQKLFDTQHRVEKMPDGSVALPVLGETLPEQHLQELRNRVAPGSPCMLTQLPDPVPSKRAQGCSPAQKLCLEVSRWVEGRGVKWSAELEADLPRSWQRHGNLLLLSEDCFQAKQWKNLGPELWETVALALGVQRLAKRGRVSPDGTRTPAVTLLLGDHGWVEHVDNGIRYKFDVTQCMFSFGNITEKLRVASLSCAGEVLVDLYAGIGYFTLPFLVHAGAAFVHACEWNPHAVVALRNNLEINGVADRCQIHFGDNRKLKLSNIADRVILGLIPSSEEGWPIACQVLRQDAGGILHIHQNVESFPGKNLQALGVSKVEKEHWLYPQQITTNQWKNGATRDSRGKMLSPATKPEWQRWAESAETRIATLLQQVHGKPWKTQILHIQPVKSYAPHVDHIVLDLECCPCPSVG
uniprot
proteins
ec_number
2.5.1.114
uniprot
proteins
function
FUNCTION: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86. {ECO:0000269|PubMed:22761755}.
uniprot
proteins
mass_dalton
50236
uniprot
proteins
mutagenesis
MUTAGEN 225; /note="K->A: Lack of activity."; /evidence="ECO:0000269|PubMed:22761755"; MUTAGEN 242; /note="Y->A: Does not affect activity."; /evidence="ECO:0000269|PubMed:22761755"; MUTAGEN 248; /note="F->A: Does not affect activity."; /evidence="ECO:0000269|PubMed:22761755"; MUTAGEN 265; /note="E->A: Lack of activity."; /evidence="ECO:0000269|PubMed:22761755"; MUTAGEN 293; /note="D->A: Does not affect activity."; /evidence="ECO:0000269|PubMed:22761755
uniprot
proteins
pathway_participation
PATHWAY: tRNA modification; wybutosine-tRNA(Phe) biosynthesis. {ECO:0000269|PubMed:22761755}.
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
TRM5/TYW2 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22761755
uniprot
proteins
sequence_length
448
uniprot
proteins