ACER1
entrez
125981
canonical
uniprot
Q8TDN7
canonical
ensembl
ENSG00000167769
resolver
ensp
ENSP00000301452
resolver
enst
ENST00000301452
resolver
genesymbol
ACER1
resolver
genesymbol_syn
ASAH3
resolver
hgnc
HGNC:18356
resolver
uniprot_entry
ACER1_HUMAN
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by sphingosine (By similarity). Activity is Ca(2+)-dependent (PubMed:17713573). {ECO:0000250|UniProtKB:Q8R4X1, ECO:0000269|PubMed:17713573}.
uniprot
proteins
amino_acid_sequence
MPSIFAYQSSEVDWCESNFQYSELVAEFYNTFSNIPFFIFGPLMMLLMHPYAQKRSRYIYVVWVLFMIIGLFSMYFHMTLSFLGQLLDEIAILWLLGSGYSIWMPRCYFPSFLGGNRSQFIRLVFITTVVSTLLSFLRPTVNAYALNSIALHILYIVCQEYRKTSNKELRHLIEVSVVLWAVALTSWISDRLLCSFWQRIHFFYLHSIWHVLISITFPYGMVTMALVDANYEMPGETLKVRYWPRDSWPVGLPYVEIRGDDKDC
uniprot
proteins
ec_number
3.5.1.-
uniprot
proteins
ec_number
3.5.1.23
uniprot
proteins
function
FUNCTION: Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH (PubMed:17713573, PubMed:20207939, PubMed:20628055). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:12783875). Exhibits a strong substrate specificity towards the natural stereoisomer of ceramides with D-erythro-sphingosine as a backbone and has a higher activity towards very long-chain unsaturated fatty acids like the C24:1-ceramide (PubMed:17713573, PubMed:20207939). May also hydrolyze dihydroceramides to produce dihydrosphingosine (PubMed:20207939, PubMed:20628055). ACER1 is a skin-specific ceramidase that regulates the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes and more generally plays an important role in skin homeostasis (PubMed:17713573). {ECO:0000269|PubMed:17713573, ECO:0000269|PubMed:20207939, ECO:0000269|PubMed:20628055, ECO:0000303|PubMed:12783875}.
uniprot
proteins
mass_dalton
31095
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; sphingolipid metabolism. {ECO:0000269|PubMed:17713573, ECO:0000269|PubMed:20207939}.
uniprot
proteins
protein_family
Alkaline ceramidase family
uniprot
proteins
pubmed
12783875
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16477081
uniprot
proteins
pubmed
17713573
uniprot
proteins
pubmed
20207939
uniprot
proteins
pubmed
20628055
uniprot
proteins
sequence_length
264
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17713573}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 28..48; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 58..78; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 82..102; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 120..137; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 139..159; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 177..197; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 207..227; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins