Bbs4
entrez
102774
canonical
uniprot
Q8C1Z7
canonical
ensembl
ENSMUSG00000025235
resolver
ensp
ENSMUSP00000026265
resolver
ensp
ENSMUSP00000212170
resolver
ensp
ENSMUSP00000212181
resolver
enst
ENSMUST00000026265
resolver
genesymbol
Bbs4
resolver
uniprot
A6H669
resolver
uniprot
Q3UYF0
resolver
uniprot
Q562E1
resolver
uniprot
Q5EBJ7
resolver
uniprot
Q8CA57
resolver
uniprot_entry
A6H669_MOUSE
resolver
uniprot_entry
BBS4_MOUSE
resolver
uniprot_sec
Q3UYF0
resolver
uniprot_sec
Q562E1
resolver
uniprot_sec
Q5EBJ7
resolver
uniprot_sec
Q8CA57
resolver
amino_acid_sequence
MAEVKLGMKTQVPASVESQKPRSKKAPDFPIVEKQNWLIHLHYIRKDYEACKAVIKEQLQETQGLCEYAIYVQALIFRLEGNIQESLELFQTCAVLSPQCADNLKQVARSLFLLGKHKAATEVYNEAAKLNQKDWEICHNLGVCYTYLKQFNKAQDQLHSALQLNKHDLTYIMLGKIHLLQGDLDKAIEIYKKAVEFSPENTELLTTLGLLYLQLGVYQKAFEHLGNALTYDPANYKAILAAGSMMQTHGDFDVALTKYRVVACAIPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILYNLGLVHLTMQQYASAFHFLSAAINFQPKMGELYMLLAVALTNLEDIENARRAYVEAVRLDKCNPLVNLNYAVLLYNQGEKKSALAQYQEMEKKVNFLKDNSPLEFDSEMVEMAQKLGAALQVGEALVWTKPVKDPKTKHRTNSGSKSATLQQPLGSIQALGQAMSSAAAYRKILSGAVGAQLPKPPSLPLEPEPEPTVEASPTEASEQKKEK
uniprot
proteins
function
FUNCTION: The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. The BBSome complex, together with the LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. Required for proper BBSome complex assembly and its ciliary localization. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
58255
uniprot
proteins
protein_family
BBS4 family
uniprot
proteins
pubmed
12016587
uniprot
proteins
pubmed
15107855
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18317593
uniprot
proteins
pubmed
22072986
uniprot
proteins
pubmed
23943788
uniprot
proteins
pubmed
24469809
uniprot
proteins
sequence_length
520
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cell projection, cilium membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000250}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:15107855, ECO:0000269|PubMed:22072986}. Cell projection, cilium {ECO:0000269|PubMed:23943788}. Note=Localizes to the pericentriolar material. Centrosomal localization requires dynein (By similarity). Localizes to the connecting cilium of photoreceptor cells (PubMed:23943788).
uniprot
proteins