FAAH
entrez
2166
canonical
uniprot
O00519
canonical
ensembl
ENSG00000117480
resolver
ensp
ENSP00000243167
resolver
enst
ENST00000243167
resolver
genesymbol
FAAH
resolver
genesymbol_syn
FAAH1
resolver
hgnc
HGNC:3553
resolver
uniprot
D3DQ19
resolver
uniprot
Q52M86
resolver
uniprot
Q5TDF8
resolver
uniprot_entry
FAAH1_HUMAN
resolver
uniprot_sec
D3DQ19
resolver
uniprot_sec
Q52M86
resolver
uniprot_sec
Q5TDF8
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by O-aryl carbamates and alpha-keto heterocycles (PubMed:17015445). Inhibited by trifluoromethyl ketone (PubMed:9122178). {ECO:0000269|PubMed:17015445, ECO:0000269|PubMed:9122178}.
uniprot
proteins
amino_acid_sequence
MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQRFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLADCETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSVGPMARDVESLALCLRALLCEDMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETKQSLEAAGHTLVPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAFLVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALDLNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMKKSVGLPVAVQCVALPWQEELCLRFMREVERLMTPEKQSS
uniprot
proteins
ec_number
3.1.1.-
uniprot
proteins
ec_number
3.5.1.99
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:17015445, PubMed:19926788, PubMed:9122178). Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (PubMed:17015445, PubMed:9122178). It can also catalyze the hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol) (PubMed:21049984). FAAH cooperates with PM20D1 in the hydrolysis of amino acid-conjugated fatty acids such as N-fatty acyl glycine and N-fatty acyl-L-serine, thereby acting as a physiological regulator of specific subsets of intracellular, but not of extracellular, N-fatty acyl amino acids (By similarity). {ECO:0000250|UniProtKB:O08914, ECO:0000269|PubMed:17015445, ECO:0000269|PubMed:19926788, ECO:0000269|PubMed:21049984, ECO:0000269|PubMed:9122178}.
uniprot
proteins
mass_dalton
63066
uniprot
proteins
protein_family
Amidase family
uniprot
proteins
pubmed
12060782
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
15254019
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
16972078
uniprot
proteins
pubmed
17015445
uniprot
proteins
pubmed
19926788
uniprot
proteins
pubmed
21049984
uniprot
proteins
pubmed
23556448
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9122178
uniprot
proteins
pubmed
9878243
uniprot
proteins
sequence_length
579
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endomembrane system {ECO:0000269|PubMed:17015445}; Single-pass membrane protein {ECO:0000269|PubMed:17015445}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17015445}. Note=Seems to be attached to intracellular membranes and a portion of the cytoskeletal network.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins