Oaz2
entrez
18247
canonical
uniprot
O08608
canonical
ensembl
ENSMUSG00000040652
resolver
ensp
ENSMUSP00000136914
resolver
enst
ENSMUST00000153700
resolver
genesymbol
Oaz2
resolver
genesymbol_syn
Sez15
resolver
uniprot_entry
OAZ2_MOUSE
resolver
amino_acid_sequence
MINTQDSSILPLSKCPQLQCCRHIVPGPLWCSDAPHPLSKIPGGRGGGRDPSLSALIYKDEKLTVTQDLPVNDGKPHIVHFQYEVTEVKVSSWDAVLSSQSLFVEIPDGLLADGSKEGLLALLEFAEEKMKVNYVFICFRKGREDRAPLLKTFSFLGFEIVRPGHPCVPSRPDVMFMVYPLDQNLSDED
uniprot
proteins
function
FUNCTION: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:16916800, PubMed:18508777, PubMed:24967154). Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (PubMed:19449338). {ECO:0000269|PubMed:16916800, ECO:0000269|PubMed:18508777, ECO:0000269|PubMed:19449338, ECO:0000269|PubMed:24967154}.
uniprot
proteins
mass_dalton
21025
uniprot
proteins
protein_family
ODC antizyme family
uniprot
proteins
pubmed
16916800
uniprot
proteins
pubmed
18508777
uniprot
proteins
pubmed
19449338
uniprot
proteins
pubmed
19725046
uniprot
proteins
pubmed
24967154
uniprot
proteins
pubmed
8645260
uniprot
proteins
pubmed
9782076
uniprot
proteins
sequence_length
189
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19725046}.
uniprot
proteins