Sf3a2
entrez
299620
canonical
uniprot
Q6AXT8
canonical
ensembl
ENSRNOG00000019349
resolver
ensembl
ENSRNOG00055031432
resolver
ensembl
ENSRNOG00060024726
resolver
ensp
ENSRNOP00000026202
resolver
ensp
ENSRNOP00055045006
resolver
ensp
ENSRNOP00060035485
resolver
enst
ENSRNOT00000026202
resolver
enst
ENSRNOT00055054436
resolver
enst
ENSRNOT00060042844
resolver
genesymbol
Sf3a2
resolver
uniprot_entry
SF3A2_RAT
resolver
amino_acid_sequence
MDFQHRPGGKTGSGGVASSSESNRDRRERLRQLALETIDINKDPYFMKNHLGSYECKLCLTLHNNEGSYLAHTQGKKHQTNLARRAAKEAKEAPAQPAPEKVKVEVKKFVKIGRPGYKVTKQRDTEMGQQSLLFQIDYPEIAEGVMPRHRFMSAYEQRIEPPDRRWQYLLMAAEPYETIAFKVPSREIDKAEGKFWTHWNRETKQFFLQFHFKMEKPPAPPSLPAGPPGVKRPPPPLMNGLPPRPPLPDALPPPPPGGLPLPPMPPTGPAPSGPPGPPQMPPPAPGVHPPAPVVHPPTSGVHPPAPGVHPPAPVVHPPTSGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPPSAGVHPQAPGVHPPAPAVHPQAPGVHPPAPGIHPQAPGVHPQPPPGVHPAAPGVHPQPPGVHPTPMPPMLRPPLPSDGPGNMPPPPPGN
uniprot
proteins
function
FUNCTION: Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3A2 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex. Interacts directly with the duplex formed by U2 snRNA and the intron. {ECO:0000250|UniProtKB:Q15428}.
uniprot
proteins
mass_dalton
49890
uniprot
proteins
protein_family
SF3A2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
471
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00130}.
uniprot
proteins