HS3ST4
entrez
9951
canonical
uniprot
Q9Y661
canonical
ensembl
ENSG00000182601
resolver
ensp
ENSP00000330606
resolver
enst
ENST00000331351
resolver
genesymbol
HS3ST4
resolver
genesymbol_syn
3OST4
resolver
hgnc
HGNC:5200
resolver
uniprot
Q5QI42
resolver
uniprot
Q8NDC2
resolver
uniprot_entry
HS3S4_HUMAN
resolver
uniprot_sec
Q5QI42
resolver
uniprot_sec
Q8NDC2
resolver
amino_acid_sequence
MARWPAPPPPPPPPPPLAAPPPPGASAKGPPARKLLFMCTLSLSVTYLCYSLLGGSGSLQFPLALQESPGAAAEPPPSPPPPSLLPTPVRLGAPSQPPAPPPLDNASHGEPPEPPEQPAAPGTDGWGLPSGGGGAQDAWLRTPLAPSEMITAQSALPEREAQESSTTDEDLAGRRAANGSSERGGAVSTPDYGEKKLPQALIIGVKKGGTRALLEAIRVHPDVRAVGVEPHFFDRNYEKGLEWYRNVMPKTLDGQITMEKTPSYFVTNEAPKRIHSMAKDIKLIVVVRNPVTRAISDYTQTLSKKPEIPTFEVLAFKNRTLGLIDASWSAIRIGIYALHLENWLQYFPLSQILFVSGERLIVDPAGEMAKVQDFLGLKRVVTEKHFYFNKTKGFPCLKKPEDSSAPRCLGKSKGRTHPRIDPDVIHRLRKFYKPFNLMFYQMTGQDFQWEQEEGDK
uniprot
proteins
ec_number
2.8.2.-
uniprot
proteins
function
FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to the 3-O- position of an N-sulfoglucosamine residue in heparan sulfate (PubMed:34351732). Is able to install the 3-O-sulfo group in a disaccharide domain consisting of -GlcA2S-GlcNS- to form the -GlcA2S-GlcNS3S- sequence, and in -IdoA2S-GlcNS-IdoA2S- to form -IdoA2S-GlcNS3S-IdoA2S- (PubMed:34351732). Does not sulfate the -GlcA-GlcNS-IdoA2S- domain (PubMed:34351732). {ECO:0000269|PubMed:34351732}.
uniprot
proteins
mass_dalton
49799
uniprot
proteins
protein_family
Sulfotransferase 1 family
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
17482450
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
34351732
uniprot
proteins
pubmed
9988767
uniprot
proteins
sequence_length
456
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 35..59; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins