Slc5a5
entrez
114613
canonical
uniprot
Q63008
canonical
ensembl
ENSRNOG00000018822
resolver
ensp
ENSRNOP00000025577
resolver
enst
ENSRNOT00000025576
resolver
genesymbol
Slc5a5
resolver
genesymbol_syn
Nis
resolver
uniprot
F1LR66
resolver
uniprot_entry
F1LR66_RAT
resolver
uniprot_entry
SC5A5_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Perchlorate inhibits iodide transport activity (PubMed:32084174). Oxyanions inhibit iodide transport activity by blocking the binding sites for iodide and one of the sodium ions (PubMed:36517601). {ECO:0000269|PubMed:32084174, ECO:0000269|PubMed:36517601}.
uniprot
proteins
amino_acid_sequence
MEGAEAGARATFGAWDYGVFATMLLVSTGIGLWVGLARGGQRSADDFFTGGRQLAAVPVGLSLAASFMSAVQVLGVPAEAARYGLKFLWMCAGQLLNSLLTAFLFLPIFYRLGLTSTYQYLELRFSRAVRLCGTLQYLVATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTLYTTVGGMKAVVWTDVFQVVVMLVGFWVILARGVILLGGPRNVLSLAQNHSRINLMDFDPDPRSRYTFWTFIVGGTLVWLSMYGVNQAQVQRYVACHTEGKAKLALLVNQLGLFLIVASAACCGIVMFVYYKDCDPLLTGRISAPDQYMPLLVLDIFEDLPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRMPGLAPRKLVFISKGLSFIYGSACLTVAALSSLLGGGVLQGSFTVMGVISGPLLGAFTLGMLLPACNTPGVLSGLAAGLAVSLWVAVGATLYPPGEQTMGVLPTSAAGCTNDSVLLGPPGATNASNGIPSSGMDTGRPALADTFYAISYLYYGALGTLTTMLCGALISYLTGPTKRSSLGPGLLWWDLARQTASVAPKEDTATLEESLVKGPEDIPAVTKKPPGLKPGAETHPLYLGHDVETNL
uniprot
proteins
function
FUNCTION: Sodium:iodide symporter that mediates the transport of iodide into the thyroid gland (PubMed:32084174, PubMed:36517601, PubMed:8559252, PubMed:9341168). Can also mediate the transport of chlorate, thiocynate, nitrate and selenocynate (PubMed:9341168). {ECO:0000269|PubMed:32084174, ECO:0000269|PubMed:36517601, ECO:0000269|PubMed:8559252, ECO:0000269|PubMed:9341168}.
uniprot
proteins
mass_dalton
65196
uniprot
proteins
mutagenesis
MUTAGEN 69; /note="S->A,C,D,K,T: Impairs sodium and iodide transport activity."; /evidence="ECO:0000269|PubMed:36517601"; MUTAGEN 72; /note="Q->A,C,E,H,N,S,T: Impairs sodium and iodide transport activity."; /evidence="ECO:0000269|PubMed:36517601"; MUTAGEN 144; /note="Y->A,E,H,K,L: Impairs sodium and iodide transport activity."; /evidence="ECO:0000269|PubMed:36517601"; MUTAGEN 225; /note="N->Q: No effect on sodium and iodide transport activity; when associated with Q-485 and Q-497."; /evidence="ECO:0000269|PubMed:36517601"; MUTAGEN 416; /note="S->A,H,T: Impairs sodium and iodide transport activity."; /evidence="ECO:0000269|PubMed:36517601"; MUTAGEN 417; /note="F->H,Y: Impairs sodium and iodide transport activity."; /evidence="ECO:0000269|PubMed:36517601"; MUTAGEN 485; /note="N->Q: No effect on sodium and iodide transport activity; when associated with Q-225 and Q-497."; /evidence="ECO:0000269|PubMed:36517601"; MUTAGEN 497; /note="N->Q: No effect on sodium and iodide transport activity; when associated with Q-225 and Q-485."; /evidence="ECO:0000269|PubMed:36517601
uniprot
proteins
protein_family
Sodium:solute symporter (SSF) (TC 2.A.21) family
uniprot
proteins
pubmed
32084174
uniprot
proteins
pubmed
36517601
uniprot
proteins
pubmed
8559252
uniprot
proteins
pubmed
9341168
uniprot
proteins
sequence_length
618
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:36517601, ECO:0000269|PubMed:9341168}; Multi-pass membrane protein {ECO:0000269|PubMed:36517601}. Cytoplasm {ECO:0000250|UniProtKB:Q92911}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..31; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:36517601, ECO:0007744|PDB:7UUY, ECO:0007744|PDB:7UUZ, ECO:0007744|PDB:7UV0"; TRANSMEM 57..80; /note="Discontinuously helical; Name=2"; /evidence="ECO:0000269|PubMed:36517601, ECO:0007744|PDB:7UUY, ECO:0007744|PDB:7UUZ, ECO:0007744|PDB:7UV0"; TRANSMEM 85..105; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:36517601, ECO:0007744|PDB:7UUY, ECO:0007744|PDB:7UUZ, ECO:0007744|PDB:7UV0"; TRANSMEM 131..157; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:36517601, ECO:0007744|PDB:7UUY, ECO:0007744|PDB:7UUZ, ECO:0007744|PDB:7UV0"; TRANSMEM 164..181; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:36517601, ECO:0007744|PDB:7UUY, ECO:0007744|PDB:7UUZ, ECO:0007744|PDB:7UV0"; TRANSMEM 190..208; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:36517601, ECO:0007744|PDB:7UUY, ECO:0007744|PDB:7UUZ, ECO:0007744|PDB:7UV0"; TRANSMEM 244..266; /note="Discontinuously helical; Name=7"; /evidence="ECO:0000269|PubMed:36517601, ECO:0007744|PDB:7UUY, ECO:0007744|PDB:7UUZ, ECO:0007744|PDB:7UV0"; TRANSMEM 279..301; /note="Helical; Name=8"; /evidence="ECO:0000269|PubMed:36517601, ECO:0007744|PDB:7UUY, ECO:0007744|PDB:7UUZ, ECO:0007744|PDB:7UV0"; TRANSMEM 336..363; /note="Helical; Name=9"; /evidence="ECO:0000269|PubMed:36517601, ECO:0007744|PDB:7UUY, ECO:0007744|PDB:7UUZ, ECO:0007744|PDB:7UV0"; TRANSMEM 387..408; /note="Helical; Name=10"; /evidence="ECO:0000269|PubMed:36517601, ECO:0007744|PDB:7UUY, ECO:0007744|PDB:7UUZ, ECO:0007744|PDB:7UV0"; TRANSMEM 412..437; /note="Helical; Name=11"; /evidence="ECO:0000269|PubMed:36517601, ECO:0007744|PDB:7UUY, ECO:0007744|PDB:7UUZ, ECO:0007744|PDB:7UV0"; TRANSMEM 442..465; /note="Helical; Name=12"; /evidence="ECO:0000269|PubMed:36517601, ECO:0007744|PDB:7UUY, ECO:0007744|PDB:7UUZ, ECO:0007744|PDB:7UV0"; TRANSMEM 521..545; /note="Helical; Name=13"; /evidence="ECO:0000269|PubMed:36517601, ECO:0007744|PDB:7UUY, ECO:0007744|PDB:7UUZ, ECO:0007744|PDB:7UV0
uniprot
proteins