P00397
uniprot
P00397
canonical
amino_acid_sequence
MFINRWLFSTNHKDIGTLYLLFGAWAGMVGTALSILIRAELGQPGALLGDDQIYNVIVTAHAFVMIFFMVMPMMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGIISHVVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGLDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMLWALGFIFLFTVGGLTGIVLSNSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMAGFVHWFPLFSGFTLDDTWAKAHFAIMFVGVNMTFFPQHFLGLSGMPRRYSDYPDAYTTWNTVSSMGSFISLTAVLIMIFMIWEAFASKREVMSVSYASTNLEWLHGCPPPYHTFEEPTYVKVK
uniprot
proteins
ec_number
7.1.1.9
uniprot
proteins
function
FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000269|PubMed:34616041, ECO:0000269|PubMed:38575788}.
uniprot
proteins
mass_dalton
56910
uniprot
proteins
pathway_participation
PATHWAY: Energy metabolism; oxidative phosphorylation. {ECO:0000269|PubMed:34616041, ECO:0000269|PubMed:38575788}.
uniprot
proteins
protein_family
Heme-copper respiratory oxidase family
uniprot
proteins
pubmed
12954771
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
34616041
uniprot
proteins
pubmed
38575788
uniprot
proteins
pubmed
7332926
uniprot
proteins
pubmed
8617953
uniprot
proteins
sequence_length
514
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:34616041, ECO:0000269|PubMed:38575788}; Multi-pass membrane protein {ECO:0000269|PubMed:34616041, ECO:0000269|PubMed:38575788}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..39; /note="Helical; Name=I"; /evidence="ECO:0000269|PubMed:34616041, ECO:0007744|PDB:7O37, ECO:0007744|PDB:7O3C"; TRANSMEM 56..80; /note="Helical; Name=II"; /evidence="ECO:0000269|PubMed:34616041, ECO:0007744|PDB:7O37, ECO:0007744|PDB:7O3C"; TRANSMEM 94..117; /note="Helical; Name=III"; /evidence="ECO:0000269|PubMed:34616041, ECO:0007744|PDB:7O37, ECO:0007744|PDB:7O3C"; TRANSMEM 144..166; /note="Helical; Name=IV"; /evidence="ECO:0000269|PubMed:34616041, ECO:0007744|PDB:7O37, ECO:0007744|PDB:7O3C"; TRANSMEM 186..208; /note="Helical; Name=V"; /evidence="ECO:0000269|PubMed:34616041, ECO:0007744|PDB:7O37, ECO:0007744|PDB:7O3C"; TRANSMEM 233..255; /note="Helical; Name=VI"; /evidence="ECO:0000269|PubMed:34616041, ECO:0007744|PDB:7O37, ECO:0007744|PDB:7O3C"; TRANSMEM 272..291; /note="Helical; Name=VII"; /evidence="ECO:0000269|PubMed:34616041, ECO:0007744|PDB:7O37, ECO:0007744|PDB:7O3C"; TRANSMEM 303..324; /note="Helical; Name=VIII"; /evidence="ECO:0000269|PubMed:34616041, ECO:0007744|PDB:7O37, ECO:0007744|PDB:7O3C"; TRANSMEM 338..360; /note="Helical; Name=IX"; /evidence="ECO:0000269|PubMed:34616041, ECO:0007744|PDB:7O37, ECO:0007744|PDB:7O3C"; TRANSMEM 371..393; /note="Helical; Name=X"; /evidence="ECO:0000269|PubMed:34616041, ECO:0007744|PDB:7O37, ECO:0007744|PDB:7O3C"; TRANSMEM 409..430; /note="Helical; Name=XI"; /evidence="ECO:0000269|PubMed:34616041, ECO:0007744|PDB:7O37, ECO:0007744|PDB:7O3C"; TRANSMEM 450..473; /note="Helical; Name=XII"; /evidence="ECO:0000269|PubMed:34616041, ECO:0007744|PDB:7O37, ECO:0007744|PDB:7O3C
uniprot
proteins