Gria3
entrez
29628
canonical
uniprot
P19492
canonical
ensembl
ENSRNOG00000007682
resolver
ensp
ENSRNOP00000010367
resolver
ensp
ENSRNOP00000031170
resolver
ensp
ENSRNOP00000098984
resolver
enst
ENSRNOT00000010367
resolver
enst
ENSRNOT00000169900
resolver
genesymbol
Gria3
resolver
genesymbol_syn
GluA3
resolver
genesymbol_syn
Glur3
resolver
uniprot
A0ABK0LBA4
resolver
uniprot
G3V6Z5
resolver
uniprot_entry
A0ABK0LBA4_RAT
resolver
uniprot_entry
G3V6Z5_RAT
resolver
uniprot_entry
GRIA3_RAT
resolver
amino_acid_sequence
MGQSVLRAVFFLVLGLLGHSHGGFPNTISIGGLFMRNTVQEHSAFRFAVQLYNTNQNTTEKPFHLNYHVDHLDSSNSFSVTNAFCSQFSRGVYAIFGFYDQMSMNTLTSFCGALHTSFVTPSFPTDADVQFVIQMRPALKGAILSLLSYYKWEKFVYLYDTERGFSVLQAIMEAAVQNNWQVTARSVGNIKDVQEFRRIIEEMDRRQEKRYLIDCEVERINTILEQVVILGKHSRGYHYMLANLGFTDILLERVMHGGANITGFQIVNNENPMVQQFIQRWVRLDEREFPEAKNAPLKYTSALTHDAILVIAEAFRYLRRQRVDVSRRGSAGDCLANPAVPWSQGIDIERALKMVQVQGMTGNIQFDTYGRRTNYTIDVYEMKVSGSRKAGYWNEYERFVPFSDQQISNDSSSSENRTIVVTTILESPYVMYKKNHEQLEGNERYEGYCVDLAYEIAKHVRIKYKLSIVGDGKYGARDPETKIWNGMVGELVYGRADIAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHLEDNNEEPRDPQSPPDPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWSYMKSAEPSVFTKTTADGVARVRKSKGKFAFLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVATPKGSALGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMMVALIEFCYKSRAESKRMKLTKNTQNFKPAPATNTQNYATYREGYNVYGTESVKI
uniprot
proteins
function
FUNCTION: Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (PubMed:1699567, PubMed:1709304, PubMed:2166337, PubMed:2168579). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission by inducing long-term potentiation (By similarity). Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of calcium (PubMed:1709304). The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (By similarity). In the presence of CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity). {ECO:0000250|UniProtKB:P42263, ECO:0000250|UniProtKB:Q9Z2W9, ECO:0000269|PubMed:1699567, ECO:0000269|PubMed:1709304, ECO:0000269|PubMed:2166337, ECO:0000269|PubMed:2168579}.
uniprot
proteins
mass_dalton
100373
uniprot
proteins
protein_family
GRIA3 subfamily
uniprot
proteins
protein_family
Glutamate-gated ion channel (TC 1.A.10.1) family
uniprot
proteins
pubmed
10027300
uniprot
proteins
pubmed
10414981
uniprot
proteins
pubmed
12761821
uniprot
proteins
pubmed
1699275
uniprot
proteins
pubmed
1699567
uniprot
proteins
pubmed
1709304
uniprot
proteins
pubmed
18817736
uniprot
proteins
pubmed
19003990
uniprot
proteins
pubmed
19265014
uniprot
proteins
pubmed
20199107
uniprot
proteins
pubmed
21317871
uniprot
proteins
pubmed
2166337
uniprot
proteins
pubmed
2168579
uniprot
proteins
pubmed
24090084
uniprot
proteins
pubmed
25524891
uniprot
proteins
pubmed
9069286
uniprot
proteins
sequence_length
888
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Postsynaptic cell membrane {ECO:0000269|PubMed:25524891}; Multi-pass membrane protein. Postsynaptic density membrane {ECO:0000269|PubMed:25524891, ECO:0000305|PubMed:10027300}.
uniprot
proteins
transmembrane_region
TRANSMEM 547..567; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 622..642; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 818..838; /note="Helical; Name=M4"; /evidence="ECO:0000250
uniprot
proteins