ORC2
entrez
4999
canonical
uniprot
Q13416
canonical
ensembl
ENSG00000115942
resolver
ensp
ENSP00000234296
resolver
ensp
ENSP00000549198
resolver
ensp
ENSP00000608791
resolver
ensp
ENSP00000608794
resolver
ensp
ENSP00000608797
resolver
ensp
ENSP00000608798
resolver
ensp
ENSP00000655177
resolver
enst
ENST00000234296
resolver
enst
ENST00000879139
resolver
enst
ENST00000938735
resolver
enst
ENST00000938738
resolver
enst
ENST00000938739
resolver
genesymbol
ORC2
resolver
genesymbol_syn
ORC2L
resolver
hgnc
HGNC:8488
resolver
uniprot
Q13204
resolver
uniprot
Q53TX5
resolver
uniprot_entry
ORC2_HUMAN
resolver
uniprot_sec
Q13204
resolver
uniprot_sec
Q53TX5
resolver
amino_acid_sequence
MSKPELKEDKMLEVHFVGDDDVLNHILDREGGAKLKKERAQLLVNPKKIIKKPEYDLEEDDQEVLKDQNYVEIMGRDVQESLKNGSATGGGNKVYSFQNRKHSEKMAKLASELAKTPQKSVSFSLKNDPEITINVPQSSKGHSASDKVQPKNNDKSEFLSTAPRSLRKRLIVPRSHSDSESEYSASNSEDDEGVAQEHEEDTNAVIFSQKIQAQNRVVSAPVGKETPSKRMKRDKTSDLVEEYFEAHSSSKVLTSDRTLQKLKRAKLDQQTLRNLLSKVSPSFSAELKQLNQQYEKLFHKWMLQLHLGFNIVLYGLGSKRDLLERFRTTMLQDSIHVVINGFFPGISVKSVLNSITEEVLDHMGTFRSILDQLDWIVNKFKEDSSLELFLLIHNLDSQMLRGEKSQQIIGQLSSLHNIYLIASIDHLNAPLMWDHAKQSLFNWLWYETTTYSPYTEETSYENSLLVKQSGSLPLSSLTHVLRSLTPNARGIFRLLIKYQLDNQDNPSYIGLSFQDFYQQCREAFLVNSDLTLRAQLTEFRDHKLIRTKKGTDGVEYLLIPVDNGTLTDFLEKEEEEA
uniprot
proteins
function
FUNCTION: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K20me3 and H4K27me3. Stabilizes LRWD1, by protecting it from ubiquitin-mediated proteasomal degradation. Also stabilizes ORC3. {ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22935713}.
uniprot
proteins
mass_dalton
65972
uniprot
proteins
protein_family
ORC2 family
uniprot
proteins
pubmed
11095689
uniprot
proteins
pubmed
12909626
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17716973
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22427655
uniprot
proteins
pubmed
22645314
uniprot
proteins
pubmed
22935713
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24989122
uniprot
proteins
pubmed
7502077
uniprot
proteins
pubmed
8808289
uniprot
proteins
sequence_length
577
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins