SMEK1
entrez
55671
canonical
uniprot
Q6IN85
canonical
ensembl
ENSG00000100796
resolver
ensp
ENSP00000450864
resolver
ensp
ENSP00000450883
resolver
ensp
ENSP00000450891
resolver
ensp
ENSP00000528639
resolver
ensp
ENSP00000589427
resolver
ensp
ENSP00000687690
resolver
ensp
ENSP00000742682
resolver
genesymbol
PPP4R3A
resolver
genesymbol
SMEK1
resolver
genesymbol_syn
KIAA2010
resolver
genesymbol_syn
PP4R3A
resolver
genesymbol_syn
SMEK1
resolver
hgnc
HGNC:20219
resolver
uniprot
Q69YK6
resolver
uniprot
Q86U23
resolver
uniprot
Q86YI7
resolver
uniprot
Q8IVG1
resolver
uniprot
Q8N6W1
resolver
uniprot
Q9H3F1
resolver
uniprot
Q9H7U8
resolver
uniprot
Q9NV01
resolver
uniprot
Q9NWP1
resolver
uniprot_entry
P4R3A_HUMAN
resolver
uniprot_entry
Q8N6W1_HUMAN
resolver
uniprot_sec
Q69YK6
resolver
uniprot_sec
Q86U23
resolver
uniprot_sec
Q86YI7
resolver
uniprot_sec
Q8IVG1
resolver
uniprot_sec
Q9H3F1
resolver
uniprot_sec
Q9H7U8
resolver
uniprot_sec
Q9NV01
resolver
uniprot_sec
Q9NWP1
resolver
amino_acid_sequence
MTDTRRRVKVYTLNEDRQWDDRGTGHVSSGYVERLKGMSLLVRAESDGSLLLESKINPNTAYQKQQDTLIVWSEAENYDLALSFQEKAGCDEIWEKICQVQGKDPSVDITQDLVDESEEERFDDMSSPGLELPSCELSRLEEIAELVASSLPSPLRREKLALALENEGYIKKLLELFHVCEDLENIEGLHHLYEIIKGIFLLNRTALFEVMFSEECIMDVIGCLEYDPALSQPRKHREFLTKTAKFKEVIPISDPELKQKIHQTYRVQYIQDMVLPTPSVFEENMLSTLHSFIFFNKVEIVGMLQEDEKFLTDLFAQLTDEATDEEKRQELVNFLKEFCAFSQTLQPQNRDAFFKTLSNMGILPALEVILGMDDTQVRSAATDIFSYLVEYNPSMVREFVMQEAQQNDDVSKKLTEQKITSKDILLINLIIEHMICDTDPELGGAVQLMGLLRTLVDPENMLATANKTEKTEFLGFFYKHCMHVLTAPLLANTTEDKPSKDDFQTAQLLALVLELLTFCVEHHTYHIKNYIINKDILRRVLVLMASKHAFLALCALRFKRKIIGLKDEFYNRYIMKSFLFEPVVKAFLNNGSRYNLMNSAIIEMFEFIRVEDIKSLTAHVIENYWKALEDVDYVQTFKGLKLRFEQQRERQDNPKLDSMRSILRNHRYRRDARTLEDEEEMWFNTDEDDMEDGEAVVSPSDKTKNDDDIMDPISKFMERKKLKESEEKEVLLKTNLSGRQSPSFKLSLSSGTKTNLTSQSSTTNLPGSPGSPGSPGSPGSPGSVPKNTSQTAAITTKGGLVGLVDYPDDDEDDDEDEDKEDTLPLSKKAKFDS
uniprot
proteins
function
FUNCTION: Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA DSB repair. {ECO:0000269|PubMed:18614045}.
uniprot
proteins
mass_dalton
95368
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the SCF(FBXO42) complex; leading to proteasomal degradation. {ECO:0000269|PubMed:41484364}.
uniprot
proteins
protein_family
SMEK family
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16085932
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18487071
uniprot
proteins
pubmed
18614045
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
41484364
uniprot
proteins
sequence_length
833
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18487071}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18487071}. Nucleus {ECO:0000269|PubMed:18487071}. Note=In interphase localized in the cytoplasm and in the nucleus (with higher levels). During metaphase located in pericentriolar regions.
uniprot
proteins