Dhrs7b
entrez
287380
canonical
uniprot
Q5RJY4
canonical
ensembl
ENSRNOG00000005360
resolver
ensembl
ENSRNOG00055025492
resolver
ensembl
ENSRNOG00060030543
resolver
ensembl
ENSRNOG00065008238
resolver
ensp
ENSRNOP00000063744
resolver
genesymbol
Dhrs7b
resolver
genesymbol_syn
Sdr32c1
resolver
uniprot
A4GWE3
resolver
uniprot_entry
PEXRP_RAT
resolver
uniprot_sec
A4GWE3
resolver
amino_acid_sequence
MISPSSRKGMLKERAMDLVTQTTILPLLFGCLGIFSLFRLLQRTRSKAYLRNAVVVVTGATSGLGKECARVFHAAGAKVVLCGRNVKALEEFTRELADSSSSQGQTHQPCVVTFDLADPGAIAPAAAEILQCFGYVDILINNAGISYRGAISDTIVDVDRKVMEINYFGPVALTKALLPSMVERKRGHIVAISSIQGKISIPFRSAYAASKHATQAFFDCLRAEMKDSDIEVTVISPGYIHTNLSVNAVTADGSRYGALDKNTAQGRSAVEVAQDIFDAVGKKKKDVLLTDFLPTMAVYIRTLAPRLFFRIMASRARKERKSKNS
uniprot
proteins
ec_number
1.1.1.101
uniprot
proteins
function
FUNCTION: Reductase required for adipogenesis and activation of PPARG nuclear receptor. Can convert acyl and alkyl dihydroxyacetone-phosphate (DHAP) into glycerolipids and ether lipids, respectively, synthesizing ether-linked phospholipids that act as agonists for PPARG. Also regulates adipogenesis by preventing adipocyte browning: following import into the nucleus, interacts with PRDM16, inhibiting the interaction between PRDM16 and PPARG and preventing differentiation of brown adipocytes. {ECO:0000250|UniProtKB:Q99J47}.
uniprot
proteins
mass_dalton
35342
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17522052
uniprot
proteins
pubmed
18775470
uniprot
proteins
sequence_length
325
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250|UniProtKB:Q99J47}; Single-pass type II membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:17522052, ECO:0000269|PubMed:18775470}; Single-pass type II membrane protein {ECO:0000255}. Nucleus {ECO:0000250|UniProtKB:Q99J47}.
uniprot
proteins
transmembrane_region
TRANSMEM 18..38; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins