MATCAP1
entrez
653319
canonical
uniprot
Q68EN5
canonical
ensembl
ENSG00000196123
resolver
ensp
ENSP00000290881
resolver
ensp
ENSP00000456838
resolver
ensp
ENSP00000457099
resolver
ensp
ENSP00000556373
resolver
ensp
ENSP00000614278
resolver
genesymbol
MATCAP1
resolver
genesymbol_syn
KIAA0895L
resolver
genesymbol_syn
MATCAP
resolver
hgnc
HGNC:34408
resolver
uniprot
A2VCS8
resolver
uniprot
Q8N3H9
resolver
uniprot
Q8NAQ5
resolver
uniprot
Q96IE5
resolver
uniprot_entry
MACA1_HUMAN
resolver
uniprot_sec
A2VCS8
resolver
uniprot_sec
Q8N3H9
resolver
uniprot_sec
Q8NAQ5
resolver
uniprot_sec
Q96IE5
resolver
amino_acid_sequence
MVLDSGAQAYDQAPPSPPTSPPSLRHRLKPSDRDGPPLYPWSQSLALPLALAVPPALQPQPEQQPFSQMLLGHRGHMRRSESTYSVNSTGRRGRGTLGRPPPGRGRNPGGGTLRPAASLPHIAKTQRDAGHIASKSPCMLVALRPTNMDRERDKFFQSHYTYNPQFEYQEPMPTAVLEKYCEASGQFIHQAVGIIEAVLEKFGTYEHFEAATGGQLLTKCQIWSIVRKYMQKEGCAGEVVVQLSEDLLSQAVMMVENSRPTLAINLTGARQYWLEGMLRHEIGTHYLRGVNNARQPWHNAEGRLRYGLRPANPTEEGLASLHSVLFRKQPFLWRAALLYYTIHRAARMSFRQLFQDLERYVQDADVRWEYCVRAKRGQTDTSLPGCFSKDQVYLDGIVRILRHRQTIDFPLLTSLGKVSYEDVDHLRPHGVLDNTRVPHFMQDLARYRQQLEHIMATNRLDEAELGRLLPD
uniprot
proteins
ec_number
3.4.17.17
uniprot
proteins
function
FUNCTION: Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:35482892). Also able to remove the C-terminal phenylalanine residue of alpha-tubulin TUBA8 (PubMed:35482892). Recognizes adjacent tubulin dimers along the same protofilament (PubMed:35482892). {ECO:0000269|PubMed:35482892}.
uniprot
proteins
mass_dalton
53446
uniprot
proteins
mutagenesis
MUTAGEN 219; /note="K->E: Reduced binding to microtubules."; /evidence="ECO:0000269|PubMed:35482892"; MUTAGEN 223; /note="W->A: Reduced binding to microtubules."; /evidence="ECO:0000269|PubMed:35482892"; MUTAGEN 227; /note="R->A: Reduced binding to microtubules."; /evidence="ECO:0000269|PubMed:35482892"; MUTAGEN 280; /note="H->A: Abolished tyrosine carboxypeptidase activity."; /evidence="ECO:0000269|PubMed:35482892"; MUTAGEN 281; /note="E->A,Q: Abolished tyrosine carboxypeptidase activity."; /evidence="ECO:0000269|PubMed:35482892"; MUTAGEN 285; /note="H->A: Abolished tyrosine carboxypeptidase activity."; /evidence="ECO:0000269|PubMed:35482892"; MUTAGEN 316; /note="E->A: Abolished tyrosine carboxypeptidase activity."; /evidence="ECO:0000269|PubMed:35482892
uniprot
proteins
protein_family
Peptidase MATCAP family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
35482892
uniprot
proteins
sequence_length
471
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:35482892}. Note=Associates with microtubules. {ECO:0000269|PubMed:35482892}.
uniprot
proteins