CEACAM8
entrez
1088
canonical
uniprot
P31997
canonical
ensembl
ENSG00000124469
resolver
ensp
ENSP00000244336
resolver
ensp
ENSP00000570056
resolver
ensp
ENSP00000775233
resolver
enst
ENST00000244336
resolver
enst
ENST00000899997
resolver
genesymbol
CEACAM8
resolver
genesymbol_syn
CGM6
resolver
hgnc
HGNC:1820
resolver
uniprot
B4DLI3
resolver
uniprot
O60399
resolver
uniprot
Q0Z7S6
resolver
uniprot
Q16574
resolver
uniprot_entry
B4DLI3_HUMAN
resolver
uniprot_entry
CEAM8_HUMAN
resolver
uniprot_entry
Q0Z7S6_HUMAN
resolver
uniprot_sec
O60399
resolver
uniprot_sec
Q16574
resolver
amino_acid_sequence
MGPISAPSCRWRIPWQGLLLTASLFTFWNPPTTAQLTIEAVPSNAAEGKEVLLLVHNLPQDPRGYNWYKGETVDANRRIIGYVISNQQITPGPAYSNRETIYPNASLLMRNVTRNDTGSYTLQVIKLNLMSEEVTGQFSVHPETPKPSISSNNSNPVEDKDAVAFTCEPETQNTTYLWWVNGQSLPVSPRLQLSNGNRTLTLLSVTRNDVGPYECEIQNPASANFSDPVTLNVLYGPDAPTISPSDTYYHAGVNLNLSCHAASNPPSQYSWSVNGTFQQYTQKLFIPNITTKNSGSYACHTTNSATGRNRTTVRMITVSDALVQGSSPGLSARATVSIMIGVLARVALI
uniprot
proteins
function
FUNCTION: Cell surface glycoprotein that plays a role in cell adhesion in a calcium-independent manner (PubMed:11590190, PubMed:2022629, PubMed:8776764). Mediates heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:11590190, PubMed:2022629, PubMed:8776764). Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764). {ECO:0000269|PubMed:11590190, ECO:0000269|PubMed:2022629, ECO:0000269|PubMed:8776764}.
uniprot
proteins
mass_dalton
38154
uniprot
proteins
mutagenesis
MUTAGEN 40..45; /note="AVPSNA->STPFNV: No effect on heterophilic cell adhesion."; /evidence="ECO:0000269|PubMed:11590190"; MUTAGEN 61..63; /note="DPR->NRI: No effect on heterophilic cell adhesion."; /evidence="ECO:0000269|PubMed:11590190"; MUTAGEN 66; /note="N->S: Inhibits heterophilic cell adhesion."; /evidence="ECO:0000269|PubMed:11590190"; MUTAGEN 72..75; /note="TVDA->RVDG: No effect on heterophilic cell adhesion."; /evidence="ECO:0000269|PubMed:11590190"; MUTAGEN 78; /note="R->A: Does not affect the monomeric structure. Loss of heterodimerization with CEACAM6."; /evidence="ECO:0000269|PubMed:26483485"; MUTAGEN 78; /note="R->Q: Inhibits heterophilic cell adhesion."; /evidence="ECO:0000269|PubMed:11590190"; MUTAGEN 85..89; /note="SNQQI->GTQQA: No effect on heterophilic cell adhesion."; /evidence="ECO:0000269|PubMed:11590190"; MUTAGEN 97; /note="N->G: No effect on heterophilic cell adhesion."; /evidence="ECO:0000269|PubMed:11590190"; MUTAGEN 123; /note="Q->A: Does not affect the monomeric structure. Decreases heterodimerization with CEACAM6."; /evidence="ECO:0000269|PubMed:26483485"; MUTAGEN 129; /note="L->A: Does not affect the monomeric structure. Loss of heterodimerization with CEACAM6."; /evidence="ECO:0000269|PubMed:26483485
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:26483485}.
uniprot
proteins
protein_family
CEA family
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
11590190
uniprot
proteins
pubmed
1427854
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16740002
uniprot
proteins
pubmed
2022629
uniprot
proteins
pubmed
2208113
uniprot
proteins
pubmed
2306228
uniprot
proteins
pubmed
26483485
uniprot
proteins
pubmed
8776764
uniprot
proteins
pubmed
9427723
uniprot
proteins
sequence_length
349
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:2208113}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:2208113}. Cell surface {ECO:0000269|PubMed:8776764}.
uniprot
proteins