Tnr
entrez
25567
canonical
uniprot
Q05546
canonical
ensembl
ENSRNOG00000002468
resolver
ensp
ENSRNOP00000003407
resolver
ensp
ENSRNOP00000111223
resolver
enst
ENSRNOT00000003407
resolver
enst
ENSRNOT00000164277
resolver
genesymbol
Tnr
resolver
uniprot
A0A096MJE6
resolver
uniprot
A0ABK0LZH6
resolver
uniprot
F1LQ63
resolver
uniprot_entry
A0ABK0LZH6_RAT
resolver
uniprot_entry
F1LQ63_RAT
resolver
uniprot_entry
TENR_RAT
resolver
uniprot_sec
A0A096MJE6
resolver
amino_acid_sequence
MGIEGETVVLKNMLIGVNLILLGSMLKPSECRLEVTTERVQRQTVEEEGGASSYNTSSKEQPMVFNHVYNINVPLESLCSSGLEASAEQDVSAEDDTLAEYTGQTSDHESQVTFTHKINLPKKACPCASSAQVLQELLSRIEMLEREVSVLRDQCNTNCCQESAATGQLDYVPHCSGHGNFSFESCGCICNEGWFGKNCSEPYCPLGCSSRGVCVDGQCICDSEYSGDDCSELRCPTDCSSRGLCVDGECVCEEPYTGEDCRELRCPGDCSGKGQCANGTCLCQEGYAGEDCSQRRCLNACSGRGHCQEGLCICEEGYQGPDCSAVTPPEDLRVAGISDRSIELEWDGPMAVTEYVISYQPSLGGLQLQQRVPGDWSGVTITELEPGLTYNISVYAVISNILSLPITAKVATHLSTPQGLQFKTITETTVEVQWEPFSFSFDGWEISFTPKNNEGGVIAQLPSDVTSFNQTGLKPGEEYIVNVVALKEQARGPPTSASVSTVIDGPTQILVRDVSDTVAFVEWTPPRAKVDFILLKYGLVGGEGGKTTFRLQPPLSQYSVQALRPGSRYEVSISAVRGTNESDASSTQFTTEIDAPKNLRVGSRTATSLDLEWDNSEAEAQEYKVVYSTLAGEQYHEVLVPKGIGPTTKTTLTDLVPGTEYGVGISAVMNSKQSIPATMNARTELDSPRDLMVTASSETSISLIWTKASGPIDHYRITFTPSSGISSEVTVPRDRTSYTLTDLEPGAEYIISITAERGRQQSLESTVDAFTGFRPISHLHFSHVTSSSVNITWSDPSPPADRLILNYSPRDEEEEMMEVLLDATKRHAVLMGLQPATEYIVNLVAVHGTVTSEPIVGSITTGIDPPKNITISNVTKDSLTVSWSPPVAPFDYYEYPIDHPSGRLDSSVVPNTVTEFTITRLYPASQYEISLNSVRGREESERICTLVHTAMDSPMDLIATNITPTEALLQWKAPMGEVENYVIVLTHFAMAGETILVDGVSEEFQLVDLLPRTHYTVTMYATSGPLVSGTIATNFSTLLDPPANLTASEVTRQSALISWQPPRAAIENYVLTYKSTDGSRKELIVDAEDTWIRLEGLSENTDYTVLLQAAQEATRSSLTSTIFTTGGRVFSHPQDCAQHLMNGDTLSGVYTIFLNGELSHKLQVYCDMTTDGGGWIVFQRRQNGQTDFFRKWADYRVGFGNLEDEFWLGLDNYHRITAQGRYELRVDMRDGQEAVFAYYDKFAVEDSRSLYKLRIGGYNGTAGDSLSYHQGRPFSTEDRDNDVAVTNCAMSYKGAWWYKNCHRTNLNGKYGESRHSQGINWYHWKGHEFSIPFVEMKMRPYIHRLTAGRKRRALKF
uniprot
proteins
function
FUNCTION: Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. Theses interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediates inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance (By similarity). {ECO:0000250, ECO:0000269|PubMed:10723065, ECO:0000269|PubMed:14681222, ECO:0000269|PubMed:9861042}.
uniprot
proteins
mass_dalton
149371
uniprot
proteins
post_translational_modification
PTM: Contains N-linked oligosaccharides, O-linked sialylated structures (By similarity). Contains O-linked chondroitin sulfate glycosaminoglycans. Contains N-linked oligosaccharides with a sulfated carbohydrate structure type GalNAc-4-SO4 or HNK-1 (SO4-3-GlcUABeta1,3GalBeta1,4GlcNAc). The levels of HNK-1 rise and fall in parallel to those of TNR during postnatal development of the cerebellum. In contrast, levels of GalNAc-4-SO4 are regulated independently from those of TNR, rising late in cerebellar development and continuing into adulthood. Early in postnatal development, GalNAc-4-SO4 is found predominantly on isoform 1, whereas in the adult it is predominantly on isoform 2. {ECO:0000250, ECO:0000269|PubMed:10723065, ECO:0000269|PubMed:12393878, ECO:0000269|PubMed:14681222}.
uniprot
proteins
protein_family
Tenascin family
uniprot
proteins
pubmed
10723065
uniprot
proteins
pubmed
12393878
uniprot
proteins
pubmed
14681222
uniprot
proteins
pubmed
15296743
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
24090084
uniprot
proteins
pubmed
28270793
uniprot
proteins
pubmed
7679676
uniprot
proteins
pubmed
9081628
uniprot
proteins
pubmed
9294172
uniprot
proteins
pubmed
9507007
uniprot
proteins
pubmed
9861042
uniprot
proteins
sequence_length
1356
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
uniprot
proteins