Npl
entrez
74091
canonical
uniprot
Q9DCJ9
canonical
ensembl
ENSMUSG00000042684
resolver
ensp
ENSMUSP00000037454
resolver
enst
ENSMUST00000041874
resolver
genesymbol
Npl
resolver
uniprot_entry
NPL_MOUSE
resolver
amino_acid_sequence
MAFPKKKLRGLVAATITPMTENGEINFPVIGQYVDYLVKEQGVKNIFVNGTTGEGLSLSVSERRQVAEEWVNQGRNKLDQVVIHVGALNVKESQELAQHAAEIGADGIAVIAPFFFKSQNKDALISFLREVAAAAPTLPFYYYHMPSMTGVKIRAEELLDGIQDKIPTFQGLKFTDTDLLDFGQCVDQNHQRQFALLFGVDEQLLSALVMGATGAVGSTYNYLGKKTNQMLEAFEQKDLASALSYQFRIQRFINYVIKLGFGVSQTKAIMTLVSGIPMGPPRLPLQKATQEFTAKAEAKLKSLDFLSSPSVKEGKPLASA
uniprot
proteins
ec_number
4.1.3.3
uniprot
proteins
function
FUNCTION: Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. {ECO:0000269|PubMed:22692205}.
uniprot
proteins
mass_dalton
35130
uniprot
proteins
pathway_participation
PATHWAY: Amino-sugar metabolism; N-acetylneuraminate degradation. {ECO:0000269|PubMed:22692205}.
uniprot
proteins
protein_family
DapA family
uniprot
proteins
protein_family
NanA subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22692205
uniprot
proteins
sequence_length
320
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins