NMUR2
entrez
56923
canonical
uniprot
Q9GZQ4
canonical
ensembl
ENSG00000132911
resolver
ensp
ENSP00000255262
resolver
enst
ENST00000255262
resolver
genesymbol
NMUR2
resolver
genesymbol_syn
NMU2
resolver
genesymbol_syn
NMU2R
resolver
genesymbol_syn
TGR1
resolver
hgnc
HGNC:16454
resolver
uniprot
Q7LC54
resolver
uniprot
Q96AM5
resolver
uniprot
Q9NRA6
resolver
uniprot_entry
NMUR2_HUMAN
resolver
uniprot_sec
Q7LC54
resolver
uniprot_sec
Q96AM5
resolver
uniprot_sec
Q9NRA6
resolver
amino_acid_sequence
MSGMEKLQNASWIYQQKLEDPFQKHLNSTEEYLAFLCGPRRSHFFLPVSVVYVPIFVVGVIGNVLVCLVILQHQAMKTPTNYYLFSLAVSDLLVLLLGMPLEVYEMWRNYPFLFGPVGCYFKTALFETVCFASILSITTVSVERYVAILHPFRAKLQSTRRRALRILGIVWGFSVLFSLPNTSIHGIKFHYFPNGSLVPGSATCTVIKPMWIYNFIIQVTSFLFYLLPMTVISVLYYLMALRLKKDKSLEADEGNANIQRPCRKSVNKMLFVLVLVFAICWAPFHIDRLFFSFVEEWSESLAAVFNLVHVVSGVFFYLSSAVNPIIYNLLSRRFQAAFQNVISSFHKQWHSQHDPQLPPAQRNIFLTECHFVELTEDIGPQFPCQSSMHNSHLPAALSSEQMSRTNYQSFHFNKT
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for the neuropeptides neuromedin-U (NMU) and neuromedin-S (NMS) (PubMed:10887190, PubMed:10894543, PubMed:35440625, PubMed:36575163). Functionally, is involved in regulation of feeding and energy balance (By similarity). Additionally may modulates blood pressure and smooth muscle contraction (By similarity). Mechanistically, upon ligand binding, couples to Galpha proteins, namely GNAQ/Gaq or GNA11/Ga11 and GNAI1/Gai subunits (PubMed:11010960, PubMed:15331768, PubMed:35440625, PubMed:36575163). GNAQ/Gaq or GNA11/Ga11 coupling leads to the activation of a phospholipase C (PLC), which hydrolyzes PIP2 (phosphatidylinositol 4,5-bisphosphate) into DAG (diacylglycerol) and IP3 (inositol trisphosphate), and subsequent intracellular calcium mobilization via IP3 receptors on the endoplasmic reticulum (PubMed:11010960, PubMed:15331768). GNAI1/Gai coupling inhibits forskolin-stimulated cAMP accumulation (PubMed:15331768). {ECO:0000250|UniProtKB:P12760, ECO:0000250|UniProtKB:Q9ESQ4, ECO:0000269|PubMed:10887190, ECO:0000269|PubMed:10894543, ECO:0000269|PubMed:11010960, ECO:0000269|PubMed:15331768, ECO:0000269|PubMed:35440625, ECO:0000269|PubMed:36575163}.
uniprot
proteins
mass_dalton
47696
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10887190
uniprot
proteins
pubmed
10894543
uniprot
proteins
pubmed
10899166
uniprot
proteins
pubmed
11010960
uniprot
proteins
pubmed
15331768
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
35440625
uniprot
proteins
pubmed
36575163
uniprot
proteins
sequence_length
415
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:35440625}; Multi-pass membrane protein {ECO:0000269|PubMed:35440625}.
uniprot
proteins
transmembrane_region
TRANSMEM 44..68; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:35440625, ECO:0000312|PDB:7W55"; TRANSMEM 83..106; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:35440625, ECO:0000312|PDB:7W55"; TRANSMEM 116..142; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:35440625, ECO:0000312|PDB:7W55"; TRANSMEM 164..184; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:35440625, ECO:0000312|PDB:7W55"; TRANSMEM 212..237; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:35440625, ECO:0000312|PDB:7W55"; TRANSMEM 268..290; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:35440625, ECO:0000312|PDB:7W55"; TRANSMEM 307..330; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:35440625, ECO:0000312|PDB:7W55
uniprot
proteins