Rapgef3
entrez
223864
canonical
uniprot
Q8VCC8
canonical
ensembl
ENSMUSG00000022469
resolver
ensp
ENSMUSP00000116426
resolver
ensp
ENSMUSP00000118148
resolver
ensp
ENSMUSP00000120126
resolver
ensp
ENSMUSP00000135238
resolver
ensp
ENSMUSP00000199855
resolver
ensp
ENSMUSP00000199856
resolver
enst
ENSMUST00000128775
resolver
genesymbol
Rapgef3
resolver
genesymbol_syn
Epac
resolver
genesymbol_syn
Epac1
resolver
uniprot
E9Q2E5
resolver
uniprot
Q3TES7
resolver
uniprot
Q3UQC2
resolver
uniprot
Q8BZK9
resolver
uniprot
Q8R1R1
resolver
uniprot_entry
E9Q2E5_MOUSE
resolver
uniprot_entry
Q3TES7_MOUSE
resolver
uniprot_entry
Q3UQC2_MOUSE
resolver
uniprot_entry
RPGF3_MOUSE
resolver
uniprot_sec
Q8BZK9
resolver
uniprot_sec
Q8R1R1
resolver
amino_acid_sequence
MKVSWPGENHWQVGPAVVESPAVGAPQVGGLPDVVPEGTLLNMVLKRMHRPRCCSYQLVFEHRRPSCIQGLRWTPLTNSEDSLDFRVSLEQATTEHVHKAGKLLHRHLLATYPTLIRDRKYHLRLYRHCCSGRELVDGILALGLGVHSRSQAVGICQVLLDEGALCHVKHDWTFQDRDAQFYRFPGPEPEPTGTQDVEEELVEAMALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILRENNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERTSQGAGPSRPPTPGRNRYTVMSGTPEKILELLLEAMRPDSSAHDPTETFLSDFLLTHSVFMPSTQLFTALLHHFHVEPADPAGGSEQEHSTYICNKRQQILRLVGRWVALYSPMLHSDPVATSFLQKLSDLVSRDARLSNLLREQYPERRRHHRLENGCGNVSPQTKARNAPVWLPNQEEPLPSSAGAIRVGDKVPYDICRPDHSVLTLHLPVTASVREVMAALAHEDHWTKGQVLVKVNSAGDVVGLQPDARGVATSLGLNERLFVVDPQEVHELTPHPEQLGPTLGSSEMLDLVSAKDLAGQLTDHDWNLFNRIHQVQEHLRDVTTANLERFMRRFNELQYWVATELCLCPVPGSRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALTKLSPPVIPFMPLLLKDVTFIHEGNHTLVENLINFEKMRMMARAVRMLHHCRSHSTAPLSPLRSRVSHIHEDSQGSRISTCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP
uniprot
proteins
function
FUNCTION: Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
103533
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
918
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
uniprot
proteins