Acvr1
entrez
79558
canonical
uniprot
P80201
canonical
ensembl
ENSRNOG00000005033
resolver
ensembl
ENSRNOG00055000748
resolver
ensembl
ENSRNOG00060008142
resolver
ensembl
ENSRNOG00065020511
resolver
ensp
ENSRNOP00000006963
resolver
ensp
ENSRNOP00000072326
resolver
ensp
ENSRNOP00000102110
resolver
ensp
ENSRNOP00000112797
resolver
ensp
ENSRNOP00055001033
resolver
ensp
ENSRNOP00060010254
resolver
ensp
ENSRNOP00065027836
resolver
enst
ENSRNOT00000006963
resolver
enst
ENSRNOT00000087071
resolver
enst
ENSRNOT00000137840
resolver
enst
ENSRNOT00000160344
resolver
enst
ENSRNOT00055001286
resolver
enst
ENSRNOT00060013471
resolver
enst
ENSRNOT00065034692
resolver
genesymbol
Acvr1
resolver
genesymbol_syn
Acvrlk2
resolver
uniprot
A0A0G2K2P7
resolver
uniprot
A0ABK0LM51
resolver
uniprot
A0ABK0M1J1
resolver
uniprot
B3DM96
resolver
uniprot_entry
A0A0G2K2P7_RAT
resolver
uniprot_entry
A0ABK0LM51_RAT
resolver
uniprot_entry
A0ABK0M1J1_RAT
resolver
uniprot_entry
ACVR1_RAT
resolver
uniprot_entry
B3DM96_RAT
resolver
amino_acid_sequence
MVDGAMILSVLMMMALPSPSMEDEEPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSVNDGFRVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNVTARLPTKGKSFPGSQNFHLEVGLIILSVVFAVCLFACILGVALRKFKRRNQERLNPRDVEYGTIEGLITTNVGDSTLAELLDHSCTSGSGSGLPFLVQRTVARQITLLECVGKGRYGEVWRGSWQGENVAVKIFSSRDEKSWFRETELYNTVMLRHENILGFIASDMTSRHSSTQLWLITHYHEMGSLYDYLQLTTLDTVSCLRIVLSIASGLAHLHIEIFGTQGKSAIAHRDLKSKNILVKKNGQCCIADLGLAVMHSQSTNQLDVGNNPRVGTKRYMAPEVLDETIQVDCFDSYKRVDIWAFGLVLWEVARRMVSNGIVEDYKPPFYDVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTLTSLAKLMKECWYQNPSARLTALRIKKTLTKIDNSLDKLKTDC
uniprot
proteins
ec_number
2.7.11.30
uniprot
proteins
function
FUNCTION: Bone morphogenetic protein (BMP) type I receptor that is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. As a type I receptor, forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A ors ACVR2B. Upon binding of ligands such as BMP7 or GDF2/BMP9 to the heteromeric complexes, type II receptors transphosphorylate ACVR1 intracellular domain. In turn, ACVR1 kinase domain is activated and subsequently phosphorylates SMAD1/5/8 proteins that transduce the signal. In addition to its role in mediating BMP pathway-specific signaling, suppresses TGFbeta/activin pathway signaling by interfering with the binding of activin to its type II receptor (By similarity). Besides canonical SMAD signaling, can activate non-canonical pathways such as p38 mitogen-activated protein kinases/MAPKs (By similarity). May promote the expression of HAMP, potentially via its interaction with BMP6 (By similarity). {ECO:0000250|UniProtKB:P15261, ECO:0000250|UniProtKB:P37172, ECO:0000250|UniProtKB:Q04771}.
uniprot
proteins
mass_dalton
57195
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
TGFB receptor subfamily
uniprot
proteins
protein_family
TKL Ser/Thr protein kinase family
uniprot
proteins
pubmed
8248234
uniprot
proteins
pubmed
8395914
uniprot
proteins
sequence_length
509
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 124..146; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins