Ckb
entrez
24264
canonical
uniprot
P07335
canonical
ensembl
ENSRNOG00000010872
resolver
ensp
ENSRNOP00000015122
resolver
genesymbol
Ckb
resolver
genesymbol_syn
Ckbb
resolver
uniprot
A0JPK7
resolver
uniprot
Q499P7
resolver
uniprot
Q5PPJ5
resolver
uniprot
Q6IRE0
resolver
uniprot
Q6P139
resolver
uniprot_entry
KCRB_RAT
resolver
uniprot_sec
A0JPK7
resolver
uniprot_sec
Q499P7
resolver
uniprot_sec
Q5PPJ5
resolver
uniprot_sec
Q6IRE0
resolver
uniprot_sec
Q6P139
resolver
amino_acid_sequence
MPFSNSHNTQKLRFPAEDEFPDLSSHNNHMAKVLTPELYAELRAKCTPSGFTLDDAIQTGVDNPGHPYIMTVGAVAGDEESYDVFKDLFDPIIEDRHGGYQPSDEHKTDLNPDNLQGGDDLDPNYVLSSRVRTGRSIRGFCLPPHCSRGERRAIEKLAVEALSSLDGDLSGRYYALKSMTEAEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKTFLVWINEEDHLRVISMQKGGNMKEVFTRFCTGLTQIETLFKSKNYEFMWNPHLGYILTCPSNLGTGLRAGVHIKLPHLGKHEKFSEVLKRLRLQKRGTGGVDTAAVGGVFDVSNADRLGFSEVELVQMVVDGVKLLIEMEQRLEQGQPIDDLMPAQK
uniprot
proteins
ec_number
2.7.3.2
uniprot
proteins
function
FUNCTION: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation. During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work. {ECO:0000250|UniProtKB:Q04447}.
uniprot
proteins
mass_dalton
42725
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the ECS(ASB9) complex, leading to its degradation by the proteasome. {ECO:0000250|UniProtKB:P12277}.
uniprot
proteins
protein_family
ATP:guanido phosphotransferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1939264
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2284002
uniprot
proteins
pubmed
2838389
uniprot
proteins
pubmed
3005113
uniprot
proteins
pubmed
6477506
uniprot
proteins
sequence_length
381
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q04447}. Mitochondrion {ECO:0000250|UniProtKB:Q04447}. Cell membrane {ECO:0000250|UniProtKB:P12277}. Note=Localizes to the mitochondria of thermogenic fat cells via the internal MTS-like signal (iMTS-L) region. {ECO:0000250|UniProtKB:Q04447}.
uniprot
proteins