PABPC1
entrez
26986
canonical
uniprot
P11940
canonical
ensembl
ENSG00000070756
resolver
ensp
ENSP00000313007
resolver
ensp
ENSP00000429892
resolver
ensp
ENSP00000503058
resolver
genesymbol
PABPC1
resolver
genesymbol_syn
PAB1
resolver
genesymbol_syn
PABP
resolver
genesymbol_syn
PABP1
resolver
genesymbol_syn
PABPC2
resolver
hgnc
HGNC:8554
resolver
uniprot
Q15097
resolver
uniprot
Q93004
resolver
uniprot_entry
PABP1_HUMAN
resolver
uniprot_sec
Q15097
resolver
uniprot_sec
Q93004
resolver
amino_acid_sequence
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
uniprot
proteins
function
FUNCTION: Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability (PubMed:11051545, PubMed:17212783, PubMed:25480299). Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2 (PubMed:11051545, PubMed:20573744). Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Involved in translationally coupled mRNA turnover (PubMed:11051545). Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain (PubMed:11051545). Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed (PubMed:18447585). By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability (PubMed:25480299). {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:17212783, ECO:0000269|PubMed:18447585, ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:25480299, ECO:0000269|PubMed:32245947}.; FUNCTION: (Microbial infection) Positively regulates the replication of dengue virus (DENV). {ECO:0000269|PubMed:26735137}.
uniprot
proteins
mass_dalton
70671
uniprot
proteins
mutagenesis
MUTAGEN 455; /note="R->A: Greatly reduces methylation by CARM1 (in vitro); when associated with A-460."; /evidence="ECO:0000269|PubMed:11850402"; MUTAGEN 460; /note="R->A: Greatly reduces methylation by CARM1 (in vitro); when associated with A-455."; /evidence="ECO:0000269|PubMed:11850402
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MAPKAPK2. {ECO:0000269|PubMed:12565831}.; PTM: Methylated by CARM1. Arg-493 is dimethylated, probably to asymmetric dimethylarginine. {ECO:0000269|PubMed:11850402, ECO:0000269|Ref.6, ECO:0000269|Ref.7}.
uniprot
proteins
protein_family
Polyadenylate-binding protein type-1 family
uniprot
proteins
pubmed
10499800
uniprot
proteins
pubmed
11051545
uniprot
proteins
pubmed
11172725
uniprot
proteins
pubmed
11287632
uniprot
proteins
pubmed
11438674
uniprot
proteins
pubmed
11850402
uniprot
proteins
pubmed
11991638
uniprot
proteins
pubmed
11997512
uniprot
proteins
pubmed
12565831
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
15314026
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16356927
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
16804161
uniprot
proteins
pubmed
17212783
uniprot
proteins
pubmed
17267499
uniprot
proteins
pubmed
17289661
uniprot
proteins
pubmed
17932509
uniprot
proteins
pubmed
18447585
uniprot
proteins
pubmed
18596238
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18799579
uniprot
proteins
pubmed
19029303
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20096703
uniprot
proteins
pubmed
20102337
uniprot
proteins
pubmed
20133758
uniprot
proteins
pubmed
20430826
uniprot
proteins
pubmed
20573744
uniprot
proteins
pubmed
21098120
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21700224
uniprot
proteins
pubmed
21765940
uniprot
proteins
pubmed
21883093
uniprot
proteins
pubmed
22872150
uniprot
proteins
pubmed
23077296
uniprot
proteins
pubmed
23125361
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23279204
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24532714
uniprot
proteins
pubmed
25220460
uniprot
proteins
pubmed
25480299
uniprot
proteins
pubmed
25940091
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26735137
uniprot
proteins
pubmed
27573237
uniprot
proteins
pubmed
27871484
uniprot
proteins
pubmed
28559491
uniprot
proteins
pubmed
28733330
uniprot
proteins
pubmed
2885805
uniprot
proteins
pubmed
28931820
uniprot
proteins
pubmed
29476152
uniprot
proteins
pubmed
31570513
uniprot
proteins
pubmed
31649314
uniprot
proteins
pubmed
32245947
uniprot
proteins
pubmed
33876849
uniprot
proteins
pubmed
7908267
uniprot
proteins
pubmed
9548260
uniprot
proteins
pubmed
9582337
uniprot
proteins
sequence_length
636
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20573744, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:23077296, ECO:0000269|PubMed:28733330, ECO:0000269|PubMed:31649314, ECO:0000269|PubMed:7908267, ECO:0000269|PubMed:9582337}. Cytoplasm, Stress granule {ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:22872150, ECO:0000269|PubMed:27573237}. Nucleus {ECO:0000269|PubMed:18799579, ECO:0000269|PubMed:9582337}. Cell projection, lamellipodium {ECO:0000269|PubMed:28733330}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs (PubMed:17289661). Shuttles between the cytoplasm and the nucleus (PubMed:9582337). During stress and in the absence of DDX3X, localizes to the nucleus (PubMed:21883093). At the leading edge of migrating fibroblasts, colocalizes with DDX3X (PubMed:28733330). Relocalizes to cytoplasmic stress granules upon cellular stress where it colocalizes with ENDOV (PubMed:27573237). In case of HRSV infection, localizes in cytoplasmic inclusion bodies substructures called inclusion bodies associated granules (IBAGs) (PubMed:31649314). {ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:21883093, ECO:0000269|PubMed:28733330, ECO:0000269|PubMed:31649314, ECO:0000269|PubMed:9582337}.
uniprot
proteins