Ccr2
entrez
12772
canonical
uniprot
P51683
canonical
ensembl
ENSMUSG00000049103
resolver
ensp
ENSMUSP00000049909
resolver
ensp
ENSMUSP00000128734
resolver
ensp
ENSMUSP00000130112
resolver
ensp
ENSMUSP00000132453
resolver
enst
ENSMUST00000055918
resolver
enst
ENSMUST00000165984
resolver
enst
ENSMUST00000168841
resolver
enst
ENSMUST00000171719
resolver
genesymbol
Ccr2
resolver
genesymbol_syn
Cmkbr2
resolver
uniprot
Q3TRK1
resolver
uniprot
Q543S8
resolver
uniprot
Q61172
resolver
uniprot_entry
CCR2_MOUSE
resolver
uniprot_entry
Q3TRK1_MOUSE
resolver
uniprot_entry
Q543S8_MOUSE
resolver
uniprot_sec
Q61172
resolver
amino_acid_sequence
MEDNNMLPQFIHGILSTSHSLFTRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILIGCKKLKSMTDIYLLNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKVFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSKQDDHHYTCGPYFTQLWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQESLGMSNCVIDKHLDQAMQVTETLGMTHCCINPVIYAFVGEKFRRYLSIFFRKHIAKRLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL
uniprot
proteins
function
FUNCTION: Key functional receptor for CCL2 but can also bind CCL7 and CCL12 chemokines (PubMed:8631787, PubMed:8662823, PubMed:8996246). Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (By similarity). Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B (By similarity). Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation (PubMed:28507030). Facilitates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression; signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R (PubMed:29930553). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (PubMed:29993042). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (PubMed:29993042). Mediates the recruitment of macrophages and monocytes to the injury site following brain injury (PubMed:24806994, PubMed:29632244). {ECO:0000250|UniProtKB:P41597, ECO:0000269|PubMed:24806994, ECO:0000269|PubMed:28507030, ECO:0000269|PubMed:29632244, ECO:0000269|PubMed:29930553, ECO:0000269|PubMed:29993042, ECO:0000269|PubMed:8631787, ECO:0000269|PubMed:8662823, ECO:0000269|PubMed:8996246}.
uniprot
proteins
mass_dalton
42783
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:P41597}.; PTM: Sulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form (By similarity). Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer (By similarity). {ECO:0000250|UniProtKB:P41597}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
24806994
uniprot
proteins
pubmed
28507030
uniprot
proteins
pubmed
29632244
uniprot
proteins
pubmed
29930553
uniprot
proteins
pubmed
29993042
uniprot
proteins
pubmed
8631787
uniprot
proteins
pubmed
8662823
uniprot
proteins
pubmed
8872898
uniprot
proteins
pubmed
8996246
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8996246}; Multi-pass membrane protein {ECO:0000255}. Note=The chemoattractant receptors are reportedly distributed throughout the cell surface; after stimulation with a ligand, such as CCL2, they are rapidly recruited into microdomain clusters at the cell membrane. {ECO:0000250|UniProtKB:P41597}.
uniprot
proteins
transmembrane_region
TRANSMEM 56..83; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 94..114; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 128..149; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 167..191; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 220..239; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 257..281; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 299..322; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins