Igfbp2
entrez
16008
canonical
uniprot
P47877
canonical
ensembl
ENSMUSG00000039323
resolver
ensp
ENSMUSP00000046610
resolver
ensp
ENSMUSP00000112706
resolver
enst
ENSMUST00000047328
resolver
enst
ENSMUST00000120564
resolver
genesymbol
Igfbp2
resolver
genesymbol_syn
Igfbp-2
resolver
uniprot
D3YU40
resolver
uniprot
Q61722
resolver
uniprot
Q91VK7
resolver
uniprot_entry
D3YU40_MOUSE
resolver
uniprot_entry
IBP2_MOUSE
resolver
uniprot_sec
Q61722
resolver
uniprot_sec
Q91VK7
resolver
amino_acid_sequence
MLPRLGGPALPLLLPSLLLLLLLGAGGCGPGVRAEVLFRCPPCTPERLAACGPPPDAPCAELVREPGCGCCSVCARQEGEACGVYIPRCAQTLRCYPNPGSELPLKALVTGAGTCEKRRVGTTPQQVADSDDDHSEGGLVENHVDGTMNMLGGGSSAGRKPLKSGMKELAVFREKVNEQHRQMGKGAKHLSLEEPKKLRPPPARTPCQQELDQVLERISTMRLPDDRGPLEHLYSLHIPNCDKHGRYNLKQCKMSLNGQRGECWCVNPNTGKPIQGAPTIRGDPECHLFYNEQQETGGAHAQSVQ
uniprot
proteins
function
FUNCTION: Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:18276763). Functions coordinately with receptor protein tyrosine phosphatase beta/PTPRB and the IGF1 receptor to regulate IGF1-mediated signaling by stimulating the phosphorylation of PTEN leading to its inactivation and AKT1 activation (PubMed:26773517). Plays a positive role in cell migration via interaction with integrin alpha5/ITGA5 through an RGD motif. Additionally, interaction with ITGA5/ITGB1 enhances the adhesion of endothelial progenitor cells to endothelial cells. Upon mitochondrial damage, facilitates apoptosis with ITGA5 of podocytes, and then activates the phosphorylation of focal adhesion kinase (FAK)-mediated mitochondrial injury. {ECO:0000250|UniProtKB:P18065, ECO:0000269|PubMed:18276763, ECO:0000269|PubMed:26773517}.
uniprot
proteins
mass_dalton
32847
uniprot
proteins
post_translational_modification
PTM: Cleaved by MMP9 leading to release of free IGF2 from IGFBP2-IGF2 complex, which contributes to enhance the motility and the growth of astrocytes. {ECO:0000250|UniProtKB:P18065}.; PTM: O-glycosylated. {ECO:0000250|UniProtKB:P18065}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18276763
uniprot
proteins
pubmed
26773517
uniprot
proteins
pubmed
7529732
uniprot
proteins
pubmed
7680327
uniprot
proteins
sequence_length
305
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P18065}.
uniprot
proteins