Glrb
entrez
14658
canonical
uniprot
P48168
canonical
ensembl
ENSMUSG00000028020
resolver
ensp
ENSMUSP00000029654
resolver
ensp
ENSMUSP00000103372
resolver
ensp
ENSMUSP00000142306
resolver
ensp
ENSMUSP00000227290
resolver
ensp
ENSMUSP00000227291
resolver
ensp
ENSMUSP00000227292
resolver
ensp
ENSMUSP00000227298
resolver
enst
ENSMUST00000029654
resolver
enst
ENSMUST00000107743
resolver
enst
ENSMUST00000194085
resolver
genesymbol
Glrb
resolver
uniprot
A0A0A6YY73
resolver
uniprot
A1KR23
resolver
uniprot
E9Q3E3
resolver
uniprot
Q5U5X3
resolver
uniprot_entry
A0A0A6YY73_MOUSE
resolver
uniprot_entry
A1KR23_MOUSE
resolver
uniprot_entry
E9Q3E3_MOUSE
resolver
uniprot_entry
GLRB_MOUSE
resolver
uniprot_sec
Q5U5X3
resolver
activity_regulation
ACTIVITY REGULATION: Channel opening is triggered by extracellular glycine (PubMed:12809985). Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 (By similarity). {ECO:0000250|UniProtKB:P48167, ECO:0000269|PubMed:12809985}.
uniprot
proteins
amino_acid_sequence
MKFSLAISFFILMSLLFEDACAKEKSSKKGKGKKKQYLCPSQQSPEDLARVPPNSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGGNAAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKPQAKNKKPPPAKPVIPTAAKRIDLYARALFPFCFLFFNVIYWSIYL
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Glrb cause the spastic condition which is characterized by muscle rigidity, tremors, myoclonic jerks, pronounced startle reaction, abnormal gait and impaired righting ability (PubMed:7920630). Neurons from the ventral horn of the spinal cord display reduced inhibitory postsynaptic currents (PubMed:12809985). Likewise, hypoglossal neurons display a dramatic reduction in the frequency and amplitude of postsynaptic inhibitory currents (PubMed:16672662). {ECO:0000269|PubMed:12809985, ECO:0000269|PubMed:16672662, ECO:0000269|PubMed:7920630}.
uniprot
proteins
function
FUNCTION: Subunit of heteromeric glycine-gated chloride channels. Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (PubMed:12809985, PubMed:16672662). {ECO:0000250|UniProtKB:P48167, ECO:0000269|PubMed:12809985, ECO:0000269|PubMed:16672662}.
uniprot
proteins
mass_dalton
55951
uniprot
proteins
protein_family
GLRB sub-subfamily
uniprot
proteins
protein_family
Glycine receptor (TC 1.A.9.3) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
12809985
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16672662
uniprot
proteins
pubmed
19723286
uniprot
proteins
pubmed
22592841
uniprot
proteins
pubmed
7920630
uniprot
proteins
pubmed
7946325
uniprot
proteins
sequence_length
496
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000269|PubMed:22592841}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23415}. Synapse {ECO:0000269|PubMed:19723286, ECO:0000269|PubMed:22592841}. Cell projection, dendrite {ECO:0000269|PubMed:19723286}. Cell membrane {ECO:0000269|PubMed:12809985}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23415}. Cytoplasm {ECO:0000250|UniProtKB:P48167}. Note=Retained in the cytoplasm upon heterologous expression by itself. Coexpression with GPHN promotes expression at the cell membrane. Coexpression with GLRA1, GLRA2 or GLRA3 promotes expression at the cell membrane. {ECO:0000250|UniProtKB:P20781}.
uniprot
proteins
transmembrane_region
TRANSMEM 269..289; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P48167"; TRANSMEM 295..315; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P48167"; TRANSMEM 328..349; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P48167"; TRANSMEM 472..495; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P48167
uniprot
proteins