DEFB1
entrez
1672
canonical
uniprot
P60022
canonical
ensembl
ENSG00000164825
resolver
ensembl
ENSG00000284881
resolver
ensp
ENSP00000297439
resolver
ensp
ENSP00000494448
resolver
enst
ENST00000297439
resolver
enst
ENST00000642865
resolver
genesymbol
DEFB1
resolver
genesymbol_syn
BD1
resolver
genesymbol_syn
HBD1
resolver
hgnc
HGNC:2766
resolver
uniprot
Q09753
resolver
uniprot_entry
DEFB1_HUMAN
resolver
uniprot_sec
Q09753
resolver
amino_acid_sequence
MRTSYLLLFTLCLLLSEMASGGNFLTGLGHRSDHYNCVSSGGQCLYSACPIFTKIQGTCYRGKAKCCK
uniprot
proteins
function
FUNCTION: Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:25122636). {ECO:0000269|PubMed:25122636}.
uniprot
proteins
mass_dalton
7420
uniprot
proteins
protein_family
Beta-defensin family
uniprot
proteins
pubmed
11486002
uniprot
proteins
pubmed
11714914
uniprot
proteins
pubmed
12010514
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23938203
uniprot
proteins
pubmed
25122636
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
7628632
uniprot
proteins
pubmed
9070620
uniprot
proteins
pubmed
9268634
uniprot
proteins
sequence_length
68
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7628632}. Membrane {ECO:0000269|PubMed:23938203}. Note=Associates with tumor cell membrane-derived microvesicles (PubMed:23938203). {ECO:0000269|PubMed:23938203}.
uniprot
proteins