Pdk4
entrez
27273
canonical
uniprot
O70571
canonical
ensembl
ENSMUSG00000019577
resolver
ensp
ENSMUSP00000019721
resolver
enst
ENSMUST00000019721
resolver
genesymbol
Pdk4
resolver
uniprot
Q544J2
resolver
uniprot_entry
PDK4_MOUSE
resolver
uniprot_entry
Q544J2_MOUSE
resolver
amino_acid_sequence
MKAARFVMRSASSLSSASLVPREVELFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQELPVRLANILKEIDILPDRLVNTPSVQLVKSWYIQSLMDLVEFHEKSPEDQKALSEFVDTLVKVRNRHHNVVPTMAQGILEYKDTCTVDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIFSDSKTGNPSHIGSIDPNCDVVAVVQDAFECAKMLCDQYYLTSPELNLTQVNGKFPGQPIHIVYVPSHLHHMLFELFKNAMRATVEHQENRPSLTPVEATVVLGKEDLTIKISDRGGGVPLRITDRLFSYTYSTAPTPVMDNSRNAPLAGFGYGLPISRLYAKYFQGDLNLYSMSGYGTDAIIYLKALSSESVEKLPVFNKSAFKHYQMSSEADDWCIPSREPKNLAKEKLAV
uniprot
proteins
ec_number
2.7.11.2
uniprot
proteins
function
FUNCTION: Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism. {ECO:0000269|PubMed:16606348, ECO:0000269|PubMed:18083902, ECO:0000269|PubMed:18430968, ECO:0000269|PubMed:19627255, ECO:0000269|PubMed:21321124, ECO:0000269|PubMed:22360721}.
uniprot
proteins
mass_dalton
46596
uniprot
proteins
protein_family
PDK/BCKDK protein kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16606348
uniprot
proteins
pubmed
17669420
uniprot
proteins
pubmed
18083902
uniprot
proteins
pubmed
18430968
uniprot
proteins
pubmed
19627255
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21321124
uniprot
proteins
pubmed
21803180
uniprot
proteins
pubmed
22360721
uniprot
proteins
pubmed
22436846
uniprot
proteins
sequence_length
412
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}.
uniprot
proteins