Tgfb1i1
entrez
84574
canonical
uniprot
Q99PD6
canonical
ensembl
ENSRNOG00000019965
resolver
ensp
ENSRNOP00000078945
resolver
ensp
ENSRNOP00000082835
resolver
enst
ENSRNOT00000097108
resolver
genesymbol
Tgfb1i1
resolver
genesymbol_syn
Ara55
resolver
uniprot
A0A8I5ZUP6
resolver
uniprot_entry
A0A8I5ZUP6_RAT
resolver
uniprot_entry
TGFI1_RAT
resolver
amino_acid_sequence
MEDLDALLSDLETTTSHMSRLGAPKERPPETLTPPPPYGHQPQTGSGESSGASGDKDHLYSTVCKPRSPKSVAPVAPPFSSSSGVLGNGLCELDRLLQELNATQFNITDEIMSQFPSSKMAEGEGKEDQSEDKSITTVPSSTFPAPSKPSATSATQELDRLMASLSDFRVQNHLPASGPPQPPAVSPTREGCPSPPGQTNKGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVVTALGRAWHPEHFLCRGCSTTLGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGEEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECLAPFSGGSFFEHEGRPLCENHFHAQRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERASKPYCQPCFLKLFG
uniprot
proteins
function
FUNCTION: Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. {ECO:0000269|PubMed:9597752}.
uniprot
proteins
mass_dalton
50123
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by gonadotropin-releasing hormone-activated SRC. {ECO:0000250}.
uniprot
proteins
protein_family
Paxillin family
uniprot
proteins
pubmed
10330411
uniprot
proteins
pubmed
10848625
uniprot
proteins
pubmed
11134073
uniprot
proteins
pubmed
11546764
uniprot
proteins
pubmed
12153727
uniprot
proteins
pubmed
12177201
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16546139
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9422762
uniprot
proteins
pubmed
9597752
uniprot
proteins
pubmed
9756887
uniprot
proteins
sequence_length
461
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, focal adhesion. Nucleus matrix. Cytoplasm, cytoskeleton. Note=Associated with the actin cytoskeleton, colocalizes with stress fibers.
uniprot
proteins