Plxnb3
entrez
140571
canonical
uniprot
Q9QY40
canonical
ensembl
ENSMUSG00000031385
resolver
ensp
ENSMUSP00000002079
resolver
enst
ENSMUST00000002079
resolver
genesymbol
Plxnb3
resolver
genesymbol_syn
Kiaa1206
resolver
genesymbol_syn
Plxn6
resolver
uniprot
A2AFF9
resolver
uniprot
Q80TH8
resolver
uniprot_entry
PLXB3_MOUSE
resolver
uniprot_sec
A2AFF9
resolver
uniprot_sec
Q80TH8
resolver
amino_acid_sequence
MLTDFLQAPVMAPWSPFSLHLLLLFLPLLPLTRVHRFSVPNTSFNHLVLAPDQGKLYVGAVNHLFQLSPELKMESVAVTGPVIDSPDCVPFRDLAECPQAQLTDNANQLLLVSSRTQELVACGQVKQGVCEKRRLGDVTQVLYQAEDPGDGQFVAANTLGVTTVGLVVPLPGRDLLLVARGLAGKLSAGVPPLTVRQLAGPQPFSSEGLGRLVVGDFSDYNNSYVGAFSDAHSAYFVFRRRGARAQTEYRSYVARVCLRDVNLYSYVEMPLTCHGQGLIQAAFLTPDTLLGAFSAGTSQAQAALCAFPLADLDRSMEQARRLCYTTGGQGPSGMEEATVEYGVTSRCVTLPPDSPESYPCGDEHTPSPIAGRQPLEAQPLLQLGQSISAVAALQTDGHTIAFLGDTQGQLHKVFLNSSHGQVYHSQQVGPPGSAISPDLLVDSNGDHLYVLTAQQVDRILVAACPQFPNCTTCLQARDPLCGWCILQGRCTRRGECGRAAQPNHWLWSYEDNHCPYIQSLLPAQHPRQEQGQIILSVPRLPTLAMDEYFHCAFGGYNSLAQVEEPHVVCTTPPQDQMPPNPPGSDHVTLPLALMFEDVVLTATTFSFYDCSAVQALEVAAPCRACVSSLWRCHWCPQSSHCIYGEHCPEGEKAVYSAQEVDILVRGPEACPQVEGLASPQLVPVGWESHVTLHIQNLHYFQGLPALYHCWLELPGKLQKLPASLEETSRDSGLIHCQAQQFYPSMSQWELPVPIYVTRGEIQRLDNAGDLHVTLYDCAMGHPDCSHCQAANGSLSCLWCGDGQPACRYGPLCPPGAVEQLCPIPSIDVIEPLTGPPEGGLAITILGSNLGQAFNDVRNAVTVAGQPCNPDPSLYRISARIVCVTSPAPNGTAGPVQVAIKSRPPGISTQNFTYQDPVLLSLNPQWGPQAGGTQLTIHGQYLQTGGNISVFVGDQPCPIQEPVCPEAIICHTMPQTEPGEAVVLIVFGHVERKLLTTPFRYTANPQLVEAEPSVSFRGGGRVIRVRGTGLDVVWQPLLSVWLEDEPKVKALGVQAQDANPRRSCGAPAADPQACIHLESGLLQCSTLCSVNSSSLLLCHSPAVPDGALPKRVFFALDNMQVDFASASGGQGFLYQPNPRLAPLSHEGITHPYHLKPGHVLDVEGEGLNLGISKEEVQVHIGDGECLVKTLTLTHLYCEPPPQAPQPTNGSGTLPQFVVQMGNLRLALGPVQYEAESMMSTFPVEAQLGLGMGAAVLIAAVLLLTLMYRHKSKKALRDYQKVLVQLENLETGVGDQCRKEFTDLMTEMTDLTSDLEASGIPFLDYRTYAERAFFPGHVGCPLQPGLEGLGEEGRSVTVRQGLTQLSNLLNSKLFLLTLIHTLEEQPSFSQRDRCHVASLLSLALHSKLEYLTDIMRTLLGDLAAHYVHKNPKLMLRRTETMVEKLLTNWLSICLYTFLKEVAGEPLYMLFRAIKYQVDKGPVDAVTGKAKRTLNDSHLLREDVEFQPLTLMALVGPEADRAAGNSGVHRVPARVLDTDTITQVKEKVLDQIYKGTPFSQRPSVHSLDLEWRSGLAGHLTLSDEDLTSVTQNHWKRLNTLQHYKVPDGATVVLIPQVHNGGTVSQSLGQTGCPSGENTPMLEDGEEGGVRLWHLVKATEEAEGAKVRRSSLRDRERERSRAKAIPEIYLTRLLSMKGTLQKFVDDTFQAILSMNRPVPIAVKYLFDFLDELAEKHGIEDPETLHIWKTNSLLLRFWVNVLKNPQLIFDVQVSDNEDAILAVIAQTFIDSCMVSEHKVGRDSPVNKLLYAREIPRYKQMVEKYYADIRQSSPASYQEMNSALAELSGNYSSAPHCLEALRELYNHIHRYYDQIISALEEDPVAQKMQLACRLQQVAALVEYKVTDL
uniprot
proteins
function
FUNCTION: Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1 (By similarity). Seem to be non-essential for normal development and function of the central nervous system. {ECO:0000250, ECO:0000269|PubMed:15218527, ECO:0000269|PubMed:20696765}.
uniprot
proteins
mass_dalton
208366
uniprot
proteins
protein_family
Plexin family
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15147296
uniprot
proteins
pubmed
15218527
uniprot
proteins
pubmed
16122393
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19699796
uniprot
proteins
pubmed
20696765
uniprot
proteins
pubmed
21706053
uniprot
proteins
sequence_length
1902
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Colocalizes with RIT2/RIN at the plasma membrane. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 1246..1266; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins