Chrdl1
entrez
83453
canonical
uniprot
Q920C1
canonical
ensembl
ENSMUSG00000031283
resolver
ensp
ENSMUSP00000074230
resolver
ensp
ENSMUSP00000108499
resolver
ensp
ENSMUSP00000173716
resolver
genesymbol
Chrdl1
resolver
genesymbol_syn
Ng1
resolver
genesymbol_syn
Nrln1
resolver
uniprot
Q3TP73
resolver
uniprot
Q924K0
resolver
uniprot
Q9EPZ9
resolver
uniprot_entry
CRDL1_MOUSE
resolver
uniprot_entry
Q3TP73_MOUSE
resolver
uniprot_sec
Q924K0
resolver
uniprot_sec
Q9EPZ9
resolver
amino_acid_sequence
MDGMKYIISLFFIFVFLEGSKTEQVKHSDTYCVFQDKKYRVGEKWHPYLEPYGLVYCVNCICSENGNVLCSRVRCPSLHCLSPVHIPHLCCPRCPDSLPPVNNKVTSKSCEYNGTTYQHGELFIAEGLFQNRQPNQCSQCSCSEGNVYCGLKTCPKLTCAFPVSVPDSCCRVCRGDAELSWEHADGDIFRQPANREARHSYLRSPYDPPPNRQAGGLPRFPGSRSHRGAVIDSQQASGTIVQIVINNKHKHGQVCVSNGKTYSHGESWHPNLRAFGIVECVLCTCNVTKQECKKIHCPNRYPCKYPQKIDGKCCKVCPEEPPSQNFDSKGSFCGEETMPVYESVFMEDGETTRKVALETERPPQVEVHVWTIQKGILQHFHIEKISKRMFGELHHFKLVTRTTLNQWKLFTEGEAQLSQMCSSQVCRTELEDLVQVLYLGRPEKDHC
uniprot
proteins
function
FUNCTION: Seems to antagonize the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation (By similarity). Antagonizes the function of BMP7 and may thus play an important role in the embryonic bone formation. Shows no inhibitory effect on the inducing activity of BMP2. Plays a role during anterior segment eye development (By similarity). {ECO:0000250, ECO:0000269|PubMed:16630536}.
uniprot
proteins
mass_dalton
50732
uniprot
proteins
post_translational_modification
PTM: May be glycosylated. {ECO:0000269|PubMed:16630536}.
uniprot
proteins
pubmed
11118896
uniprot
proteins
pubmed
11441185
uniprot
proteins
pubmed
16630536
uniprot
proteins
sequence_length
447
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
uniprot
proteins