METTL21C
entrez
196541
canonical
uniprot
Q5VZV1
canonical
ensembl
ENSG00000139780
resolver
ensp
ENSP00000267273
resolver
enst
ENST00000267273
resolver
genesymbol
METTL21C
resolver
genesymbol_syn
C13orf39
resolver
hgnc
HGNC:33717
resolver
uniprot_entry
MT21C_HUMAN
resolver
amino_acid_sequence
MDVCLSSAQQPGRRGEGLSSPGGWLEAEKKGAPQKDSTGGVLEESNKIEPSLHSLQKFVPTDYASYTQEHYRFAGKEIVIQESIESYGAVVWPGAMALCQYLEEHAEELNFQDAKILEIGAGPGLVSIVASILGAQVTATDLPDVLGNLQYNLLKNTLQCTAHLPEVKELVWGEDLDKNFPKSAFYYDYVLASDVVYHHYFLDKLLTTMVYLSQPGTVLLWANKFRFSTDYEFLDKFKQVFDTTLLAEYPESSVKLFKGILKWD
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Protein-lysine N-methyltransferase using S-adenosyl-L-methionine as methyl donor (PubMed:22948820, PubMed:32611769). Mono-di and trimethylates 'Lys-943' of AARS1 (PubMed:32611769). {ECO:0000269|PubMed:22948820, ECO:0000269|PubMed:32611769}.
uniprot
proteins
mass_dalton
29565
uniprot
proteins
mutagenesis
MUTAGEN 92; /note="W->A: Abolishes methyltransferase activity; when associated with A-197."; /evidence="ECO:0000269|PubMed:32611769"; MUTAGEN 141; /note="D->A: Abolishes methyltransferase activity."; /evidence="ECO:0000269|PubMed:22948820"; MUTAGEN 197; /note="Y->A: Abolishes methyltransferase activity; when associated with A-92."; /evidence="ECO:0000269|PubMed:32611769
uniprot
proteins
protein_family
METTL21 family
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22948820
uniprot
proteins
pubmed
23349634
uniprot
proteins
pubmed
32611769
uniprot
proteins
sequence_length
264
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23349634}. Cytoplasm {ECO:0000269|PubMed:32611769}.
uniprot
proteins