Sae1
entrez
56459
canonical
uniprot
Q9R1T2
canonical
ensembl
ENSMUSG00000052833
resolver
ensp
ENSMUSP00000092409
resolver
ensp
ENSMUSP00000147409
resolver
ensp
ENSMUSP00000147771
resolver
ensp
ENSMUSP00000293609
resolver
genesymbol
Sae1
resolver
genesymbol_syn
Aos1
resolver
genesymbol_syn
Sua1
resolver
genesymbol_syn
Ubl1a1
resolver
genesymbol_syn
Uble1a
resolver
uniprot
Q3TRG9
resolver
uniprot
Q3TWJ0
resolver
uniprot
Q9CSW9
resolver
uniprot_entry
SAE1_MOUSE
resolver
uniprot_sec
Q3TRG9
resolver
uniprot_sec
Q3TWJ0
resolver
uniprot_sec
Q9CSW9
resolver
amino_acid_sequence
MVEKEEAGGGGGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLIVGMKGLGAEIAKNLILAGVKGLTMLDHEQVSPEDPGAQFLIQTGSVGRNRAEASLERAQNLNPMVDVKVDTEDVEKKPESFFTKFDAVCLTCCSRDVIIKVDQICHRNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTKVAKVSQGVEDGPEAKRAKLDSSETTMVKKKVLFCPVKEALEVDWSGEKAKAALKRTAPDYFLLQVLLKFRTDKGRDPTSESYKEDAELLLQIRNDVFDSLGISPDLLPDDFVRYCFSEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGSGIVECLGPQ
uniprot
proteins
function
FUNCTION: The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2 (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
38620
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein sumoylation.
uniprot
proteins
protein_family
Ubiquitin-activating E1 family
uniprot
proteins
pubmed
11481243
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
350
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins