Magi2
entrez
113970
canonical
uniprot
O88382
canonical
ensembl
ENSRNOG00000013962
resolver
ensp
ENSRNOP00000090186
resolver
ensp
ENSRNOP00000091952
resolver
ensp
ENSRNOP00000095318
resolver
enst
ENSRNOT00000094238
resolver
enst
ENSRNOT00000095227
resolver
enst
ENSRNOT00000115899
resolver
genesymbol
Magi2
resolver
genesymbol_syn
Acvrinp1
resolver
genesymbol_syn
Aip1
resolver
genesymbol_syn
Sscam
resolver
uniprot
A0A8I6AD37
resolver
uniprot
A0A8I6AH48
resolver
uniprot
A0A8I6AQ06
resolver
uniprot
Q9R271
resolver
uniprot_entry
A0A8I6AD37_RAT
resolver
uniprot_entry
A0A8I6AH48_RAT
resolver
uniprot_entry
A0A8I6AQ06_RAT
resolver
uniprot_entry
MAGI2_RAT
resolver
uniprot_sec
Q9R271
resolver
amino_acid_sequence
MSKSLKKKSHWTSKVHESVIGRNPEGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKLVSEELLLEVNETPVAGLTIRDVLAVIKHCKDPLRLKCVKQGGIVDKDLRHYLNLRFQKGSVDHELQQIIRDNLYLRTVPCTTRPHKEGEVPGVDYIFITVEDFMELEKSGALLESGTYEDNYYGTPKPPAEPAPLLLNVTDQILPGATPSAEGKRKRNKSVTNMEKASIEPPEEEEEERPVVNGNGVVITPESSEHEDKSAGASGETPSQPYPAPVYSQPEELKDQMDDTKSTKPEENEDSDPLPDNWEMAYTEKGEVYFIDHNTKTTSWLDPRLAKKAKPAEECKENELPYGWEKIDDPIYGTYYVDHINRRTQFENPVLEAKRKLQQHNMPHTELGTKPLQAPGFREKPLFTRDASQLKGTFLSTTLKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHADVVKLFQSVPIGQSVNLVLCRGYPLPFDPEDPANSMVPPLAIMERPPPVMVNGRHNYETYLEYISRTSQSVPDITDRPPHSLHSMPADGQLDGTYPPPVHDDNVSVASSGATQAELMTLTIVKGAKGFGFTIADSPTGQRVKQILDIQGCPGLCEGDLIVEINQQNVQNLSHTEVVDILKDCPVGSETSLIIHRGGFFSPWKTPKPMVDRWENQGSPQTSLSAPAVPQSLPFPPALHRSSFPDSTEAFDPRKPDPYELYEKSRAIYESRQQVPPRTSFRMDSSGPDYKELDVHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTHRYVIDLMHHAARNGQVNLTVRRKVLCGGEPCPENGRSPGSVSTHHSSPRSDYATYANSNHAAPSNNASPPEGFASHSLQTSDVIIHRKENEGFGFVIISSLNRPESGATITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIINMPHADIVKLIKDAGLSVTLRIIPQEELNNPTSAPSSEKQSPMAQQHSPLAQQHSPLAQPSPATPNSPVAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIRQPPFTDYRQPPLDYRQPPGGDYSQPSPLDYRQHSPDTRQYPLSDYRQPQDFDYFTVDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIKSGGRRVRLLLKRGTGQVPEYGMVPSSLSMCMKSDKHGSPYFYLLGHPKDTTNPTPGALPLPPPQACRK
uniprot
proteins
function
FUNCTION: Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins (PubMed:9694864). Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth (PubMed:17724123). May play a role in regulating activin-mediated signaling in neuronal cells (By similarity). Enhances the ability of PTEN to suppress AKT1 activation (By similarity). Plays a role in receptor-mediated clathrin-dependent endocytosis which is required for ciliogenesis (By similarity). {ECO:0000250|UniProtKB:Q86UL8, ECO:0000250|UniProtKB:Q9WVQ1, ECO:0000269|PubMed:17724123, ECO:0000269|PubMed:9694864}.
uniprot
proteins
mass_dalton
141072
uniprot
proteins
protein_family
MAGUK family
uniprot
proteins
pubmed
10080919
uniprot
proteins
pubmed
10207009
uniprot
proteins
pubmed
10548487
uniprot
proteins
pubmed
10644767
uniprot
proteins
pubmed
12589829
uniprot
proteins
pubmed
15951562
uniprot
proteins
pubmed
15994232
uniprot
proteins
pubmed
16464232
uniprot
proteins
pubmed
16751601
uniprot
proteins
pubmed
17724123
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23751499
uniprot
proteins
pubmed
9694864
uniprot
proteins
sequence_length
1277
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Late endosome. Synapse, synaptosome. Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9WVQ1}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9WVQ1}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q9WVQ1}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q9WVQ1}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q9WVQ1}. Note=Membrane-associated in synaptosomes. Localized diffusely in the cytoplasm before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation.
uniprot
proteins