SLC22A11
entrez
55867
canonical
uniprot
Q9NSA0
canonical
ensembl
ENSG00000168065
resolver
ensp
ENSP00000301891
resolver
ensp
ENSP00000366809
resolver
genesymbol
SLC22A11
resolver
genesymbol_syn
OAT4
resolver
hgnc
HGNC:18120
resolver
uniprot
A8K426
resolver
uniprot
Q53GR2
resolver
uniprot
Q6ZP72
resolver
uniprot
Q8NBU4
resolver
uniprot_entry
S22AB_HUMAN
resolver
uniprot_sec
A8K426
resolver
uniprot_sec
Q53GR2
resolver
uniprot_sec
Q6ZP72
resolver
uniprot_sec
Q8NBU4
resolver
amino_acid_sequence
MAFSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCWTHMLDNGSAVSTNMTPKALLTISIPPGPNQGPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWCCLQLAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGCAFSAGQAALGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQALQELRKVARINGHKEAKNLTIEVLMSSVKEEVASAKEPRSVLDLFCVPVLRWRSCAMLVVNFSLLISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQAMAGLAILANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILHTVGRLGAMMGPLILMSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDTIQDLESQKSTAAQGNRQEAVTVESTSL
uniprot
proteins
function
FUNCTION: Antiporter that mediates the transport of conjugated steroids and other specific organic anions at the basal membrane of syncytiotrophoblast and at the apical membrane of proximal tubule epithelial cells, in exchange for anionic compounds (PubMed:10660625, PubMed:11907186, PubMed:15037815, PubMed:15102942, PubMed:15291761, PubMed:15576633, PubMed:17229912, PubMed:18501590, PubMed:26277985, PubMed:28027879). May be responsible for placental absorption of fetal-derived steroid sulfates such as estrone sulfate (E1S) and the steroid hormone precursor dehydroepiandrosterone sulfate (DHEA-S), as well as clearing waste products and xenobiotics from the fetus (PubMed:12409283). Maybe also be involved in placental urate homeostasis (PubMed:17229912). Facilitates the renal reabsorption of organic anions such as urate and derived steroid sulfates (PubMed:15037815, PubMed:17229912). Organic anion glutarate acts as conteranion for E1S renal uptake (PubMed:15037815, PubMed:17229912). Possible transport mode may also include DHEA-S/E1S exchange (PubMed:28027879). Also interacts with inorganic anions such as chloride and hydroxyl ions, therefore possible transport modes may include E1S/Cl(-), E1S/OH(-), urate/Cl(-) and urate/OH(-) (PubMed:17229912). Also mediates the transport of prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may be involved in their renal excretion (PubMed:11907186). Also able to uptake anionic drugs, diuretics, bile salts and ochratoxin A (PubMed:10660625, PubMed:26277985). Mediates the unidirectional efflux of glutamate and aspartate (PubMed:28027879). Glutamate efflux down its transmembrane gradient may drive SLC22A11/OAT4-mediated placental uptake of E1S (PubMed:26277985). {ECO:0000269|PubMed:10660625, ECO:0000269|PubMed:11907186, ECO:0000269|PubMed:12409283, ECO:0000269|PubMed:15037815, ECO:0000269|PubMed:15102942, ECO:0000269|PubMed:15291761, ECO:0000269|PubMed:15576633, ECO:0000269|PubMed:17229912, ECO:0000269|PubMed:18501590, ECO:0000269|PubMed:26277985, ECO:0000269|PubMed:28027879, ECO:0000303|PubMed:17229912}.
uniprot
proteins
mass_dalton
59972
uniprot
proteins
mutagenesis
MUTAGEN 39; /note="N->Q: No visible effect on N-glycosylation. Loss of N-glycosylation and of cell surface location; when associated with Q-56; Q-63 and Q-99."; /evidence="ECO:0000269|PubMed:15576633"; MUTAGEN 47; /note="H->A: Reduced cell surface expression and estrone 3-sulfate transport. Reduced cell surface expression and estrone 3-sulfate transport; when associated with A-52; A-83; A-305 and A-469."; /evidence="ECO:0000269|PubMed:15291761"; MUTAGEN 52; /note="H->A: Slightly reduced estrone 3-sulfate transport. Reduced cell surface expression and estrone 3-sulfate transport; when associated with A-47; A-83; A-305 and A-469."; /evidence="ECO:0000269|PubMed:15291761"; MUTAGEN 56; /note="N->Q: No visible effect on N-glycosylation. Loss of N-glycosylation and of cell surface expression; when associated with Q-39; Q-63 and Q-99."; /evidence="ECO:0000269|PubMed:15576633"; MUTAGEN 63; /note="N->Q: No visible effect on N-glycosylation. Loss of N-glycosylation and of cell surface expression; when associated with Q-39; Q-56 and Q-99."; /evidence="ECO:0000269|PubMed:15576633"; MUTAGEN 83; /note="H->A: Reduced cell surface expression and estrone 3-sulfate transport; when associated with A-47; A-52; A-305 and A-469."; /evidence="ECO:0000269|PubMed:15291761"; MUTAGEN 99; /note="N->Q: No visible effect on N-glycosylation. Loss of N-glycosylation and of cell surface expression; when associated with Q-39; Q-56 and Q-63."; /evidence="ECO:0000269|PubMed:15576633"; MUTAGEN 241; /note="G->L,S,V: Strongly reduced cell surface expression and estrone 3-sulfate transport."; /evidence="ECO:0000269|PubMed:15102942"; MUTAGEN 305; /note="H->A: Reduced cell surface expression and estrone 3-sulfate transport; when associated with A-47; A-52; A-83 and A-469."; /evidence="ECO:0000269|PubMed:15291761"; MUTAGEN 400; /note="G->L,S,V: Strongly reduced cell surface expression and estrone 3-sulfate transport."; /evidence="ECO:0000269|PubMed:15102942"; MUTAGEN 469; /note="H->A: Slightly reduced estrone 3-sulfate transport. Reduced cell surface expression and estrone 3-sulfate transport; when associated with A-47; A-52; A-83 and A-305."; /evidence="ECO:0000269|PubMed:15291761
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. Contains several complex-type N-glycans. {ECO:0000269|PubMed:15576633}.
uniprot
proteins
protein_family
Major facilitator (TC 2.A.1) superfamily
uniprot
proteins
protein_family
Organic cation transporter (TC 2.A.1.19) family
uniprot
proteins
pubmed
10660625
uniprot
proteins
pubmed
11907186
uniprot
proteins
pubmed
12409283
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15037815
uniprot
proteins
pubmed
15102942
uniprot
proteins
pubmed
15291761
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15576633
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17229912
uniprot
proteins
pubmed
18501590
uniprot
proteins
pubmed
26277985
uniprot
proteins
pubmed
28027879
uniprot
proteins
sequence_length
550
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15291761, ECO:0000269|PubMed:15576633}; Multi-pass membrane protein {ECO:0000269|PubMed:15291761, ECO:0000269|PubMed:15576633}. Apical cell membrane {ECO:0000269|PubMed:15037815}; Multi-pass membrane protein {ECO:0000269|PubMed:15291761, ECO:0000269|PubMed:15576633}. Basal cell membrane {ECO:0000269|PubMed:12409283}; Multi-pass membrane protein {ECO:0000269|PubMed:15291761, ECO:0000269|PubMed:15576633}. Note=Expressed at the apical membrane of the proximal tubule epithelial cells (PubMed:15037815). Expressed at the basal membrane of the syncytiotrophoblast (PubMed:12409283). {ECO:0000269|PubMed:12409283, ECO:0000269|PubMed:15037815}.
uniprot
proteins
transmembrane_region
TRANSMEM 11..31; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 143..163; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 175..195; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 201..221; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 232..252; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 257..277; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 347..367; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 379..399; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 403..423; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 431..451; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 464..484; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 491..511; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins