Fzd8
entrez
364754
canonical
uniprot
Q498S8
canonical
ensembl
ENSRNOG00000069521
resolver
ensembl
ENSRNOG00055006548
resolver
ensembl
ENSRNOG00060017051
resolver
ensembl
ENSRNOG00065021350
resolver
ensp
ENSRNOP00000093389
resolver
ensp
ENSRNOP00055008264
resolver
ensp
ENSRNOP00060023447
resolver
ensp
ENSRNOP00065029228
resolver
enst
ENSRNOT00000116071
resolver
enst
ENSRNOT00055010655
resolver
enst
ENSRNOT00060029122
resolver
enst
ENSRNOT00065036272
resolver
genesymbol
Fzd8
resolver
uniprot_entry
FZD8_RAT
resolver
amino_acid_sequence
MEWGYLLEVTSLLAALAVLQRSSGAAAASAKELACQEITVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNRTDLTTAAPSPPRRLPPPQPGEQPPSGSGHSRPPGARPPHRGGSSRGSGDTAAAPPSRGGKARPPGGGAAPCEPGCQCRAPMVSVSSERHPLYNRVKTGQIANCALPCHNPFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDMERFKYPERPIIFLSACYLFVSVGYLVRLVAGHEKVACSGGAPGAGGAGGAGGAATAGAGAAGAGASSPGARGEYEELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQQGGPTKTHKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQHNRPRWEATHNCPCLRDLQPDQARRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWRALCTRCCWASKGAAVGAGAGGSGPGGGGPGPGGGGGHGGGGGSLYSDVSTGLTWRSGTASSVSYPKQMPLSQV
uniprot
proteins
function
FUNCTION: Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1 (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
73009
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. {ECO:0000250}.
uniprot
proteins
protein_family
G protein-coupled receptor Fz/Smo family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
684
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Golgi apparatus {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Colocalizes with GOPC at the Golgi apparatus. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 272..292; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 309..329; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 394..414; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 437..457; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 481..501; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 530..550; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 582..602; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins