TACSTD2
entrez
4070
canonical
uniprot
P09758
canonical
ensembl
ENSG00000184292
resolver
ensp
ENSP00000360269
resolver
enst
ENST00000371225
resolver
genesymbol
TACSTD2
resolver
genesymbol_syn
GA733-1
resolver
genesymbol_syn
M1S1
resolver
genesymbol_syn
TROP2
resolver
hgnc
HGNC:11530
resolver
uniprot
Q15658
resolver
uniprot
Q6FG48
resolver
uniprot
Q7Z7Q4
resolver
uniprot
Q96QD2
resolver
uniprot_entry
TACD2_HUMAN
resolver
uniprot_sec
Q15658
resolver
uniprot_sec
Q6FG48
resolver
uniprot_sec
Q7Z7Q4
resolver
uniprot_sec
Q96QD2
resolver
amino_acid_sequence
MARGPGLAPPPLRLPLLLLVLAAVTGHTAAQDNCTCPTNKMTVCSPDGPGGRCQCRALGSGMAVDCSTLTSKCLLLKARMSAPKNARTLVRPSEHALVDNDGLYDPDCDPEGRFKARQCNQTSVCWCVNSVGVRRTDKGDLSLRCDELVRTHHILIDLRHRPTAGAFNHSDLDAELRRLFRERYRLHPKFVAAVHYEQPTIQIELRQNTSQKAAGDVDIGDAAYYFERDIKGESLFQGRGGLDLRVRGEPLQVERTLIYYLDEIPPKFSMKRLTAGLIAVIVVVVVALVAGMAVLVITNRRKSGKYKKVEIKELGELRKEPSL
uniprot
proteins
disease_involvement
DISEASE: Corneal dystrophy, gelatinous drop-like (GDLD) [MIM:204870]: A form of lattice corneal dystrophy, a class of inherited stromal amyloidoses characterized by pathognomonic branching lattice figures in the cornea. GDLD is an autosomal recessive disorder characterized by severe corneal amyloidosis leading to blindness. Clinical manifestations, which appear in the first decade of life, include blurred vision, photophobia, and foreign-body sensation. By the third decade, raised, yellowish-gray, gelatinous masses severely impair visual acuity. {ECO:0000269|PubMed:10192395}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: May function as a growth factor receptor.
uniprot
proteins
mass_dalton
35709
uniprot
proteins
post_translational_modification
PTM: The N-terminus is blocked.
uniprot
proteins
protein_family
EPCAM family
uniprot
proteins
pubmed
10192395
uniprot
proteins
pubmed
11687514
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2911574
uniprot
proteins
pubmed
7665234
uniprot
proteins
pubmed
8382772
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 275..297; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins