Ppargc1a
entrez
83516
canonical
uniprot
Q9QYK2
canonical
ensembl
ENSRNOG00000004473
resolver
ensp
ENSRNOP00000086053
resolver
ensp
ENSRNOP00000093101
resolver
ensp
ENSRNOP00000098873
resolver
ensp
ENSRNOP00000102592
resolver
enst
ENSRNOT00000108897
resolver
enst
ENSRNOT00000116869
resolver
enst
ENSRNOT00000133457
resolver
enst
ENSRNOT00000145100
resolver
genesymbol
Ppargc1a
resolver
genesymbol_syn
Pgc1
resolver
genesymbol_syn
Pgc1a
resolver
genesymbol_syn
Ppargc1
resolver
uniprot
A0A8I6A531
resolver
uniprot
A0A8I6AWK0
resolver
uniprot
A0ABK0KWK4
resolver
uniprot_entry
A0A8I6A531_RAT
resolver
uniprot_entry
A0A8I6AWK0_RAT
resolver
uniprot_entry
A0ABK0KWK4_RAT
resolver
uniprot_entry
PRGC1_RAT
resolver
amino_acid_sequence
MAWDMCSQDSVWSDIECAALVGEDQPLCPDLPELDLSELDVNDLDTDSFLGGLKWCSDQSEIISNQYNNEPANIFEKIDEENEANLLAVLTETLDSLPVDEDGLPSFDALTDGDVTTDNEASPSSMPDGTPPPQEAEEPSLLKKLLLAPANTQLSYNECSGLSTQNHANHTHRIRTNPAIVKTENSWSNKAKSICQQQKPQRRPCSELLKYLTTNDDPPHTKPTENRNSSRDKCASKKKSHTQPQSQHAQAKPTTLSLPLTPESPNDPKGSPFENKTIERTLSVELSGTAGLTPPTTPPHKANQDNPFKASPKLKPSCKTVVPPPTKRARYSECSGTQGSHSTKKGPEQSELYAQLSKSSVLSRGHEERKTKRPSLRLFGDHDYCQSVNSKTDILINISQELQDSRQLDFKDASCDWQGHICSSTDSSQCYLRETLEASKQVSPCSTRKQLQDQEIRAELNKHFGHPSQAVFDDKVDKTSELRDGNFSNEQFSKLPVFINSGLAMDGLFDDSEDENDKLSYPWDGTQSYSLFDVSPSCSSFNSPCRDSVSPPKSLFSQRPQRMRSRSRSFSRHRSCSRSPYSRSRSRSPGSRSSSRSCYYYESSHYRHRTHRNSPLYVRSRSRSPYSRRPRYDSYEANEHERLKRDEYRREYEKRESERAKQRERQKQKAIEERRVIYVGKIRPDTTRTELRDRFEVFGEIEECTVNLRDDGDSYGFITYRYTCDAFAALENGYTLRRSNETDFELYFCGRKQFFKSNYADLDSNSDDFDPASTKSKYDSLDFDSLLKEAQRSLRR
uniprot
proteins
function
FUNCTION: Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program (By similarity). Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (By similarity). {ECO:0000250|UniProtKB:O70343, ECO:0000250|UniProtKB:Q9UBK2}.
uniprot
proteins
mass_dalton
90622
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by AMPK in skeletal muscle increases activation of its own promoter. Phosphorylated by CLK2. {ECO:0000250|UniProtKB:O70343}.; PTM: Heavily acetylated by KAT2A/GCN5 under conditions of high nutrients, leading to inactivation of PPARGC1A. Deacetylated by SIRT1 in low nutrients/high NAD conditions, leading to its activation. {ECO:0000250|UniProtKB:Q9UBK2}.; PTM: Ubiquitinated. Ubiquitination by RNF34 induces proteasomal degradation. {ECO:0000250|UniProtKB:Q9UBK2}.
uniprot
proteins
pubmed
10913342
uniprot
proteins
pubmed
11108270
uniprot
proteins
sequence_length
796
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O70343}. Nucleus, PML body {ECO:0000250|UniProtKB:O70343}.
uniprot
proteins