Mt-atp8
entrez
26196
canonical
uniprot
P11608
canonical
genesymbol
Mt-atp8
resolver
genesymbol_syn
ATP8
resolver
genesymbol_syn
Atp8
resolver
genesymbol_syn
Atpase8
resolver
genesymbol_syn
Mtatp8
resolver
uniprot
Q35736
resolver
uniprot
Q8HIC8
resolver
uniprot_entry
ATP8_RAT
resolver
uniprot_entry
Q8HIC8_RAT
resolver
uniprot_sec
Q35736
resolver
amino_acid_sequence
MPQLDTSTWFITIISSMATLFILFQLKISSQTFPAPPSPKTMATEKTNNPWESKWTKTYLPLSLPPQ
uniprot
proteins
function
FUNCTION: Subunit 8, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity). In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro (By similarity). Part of the complex F(0) domain (By similarity). {ECO:0000250|UniProtKB:P03928, ECO:0000250|UniProtKB:P19483}.
uniprot
proteins
mass_dalton
7630
uniprot
proteins
protein_family
ATPase protein 8 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
17575325
uniprot
proteins
pubmed
24185961
uniprot
proteins
pubmed
2504926
uniprot
proteins
pubmed
3360805
uniprot
proteins
pubmed
8529844
uniprot
proteins
sequence_length
67
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion membrane; Single-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 8..24; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins