Atpsckmt
entrez
68073
canonical
uniprot
Q9D1Z3
canonical
ensembl
ENSMUSG00000039065
resolver
ensp
ENSMUSP00000039094
resolver
ensp
ENSMUSP00000124619
resolver
enst
ENSMUST00000042702
resolver
enst
ENSMUST00000161061
resolver
genesymbol
Atpsckmt
resolver
genesymbol_syn
Fam173b
resolver
uniprot
E0CXY7
resolver
uniprot
Q8K2S1
resolver
uniprot_entry
ACKMT_MOUSE
resolver
uniprot_entry
E0CXY7_MOUSE
resolver
uniprot_sec
Q8K2S1
resolver
amino_acid_sequence
MERVGTPEEERQAGPVLPTSLESDSSKRTSWGFLITGVVGGALLTVYAVATPFITPALRKVCLPFVPATSKQVENVVRMLRHRRGPLVDIGSGDGRIVIAAAKEGFPAVGYELNPWLVWYSRYRAWRAGVHGSAKFYISDLWKVTFAQYSNVVIFGVPQMMPQLEKKLELELEDGARVIACRFPFPRWTPDHTTGEGIDTVWAYDMSAQRGRGGRPNQEWVGQKNLSETAGLQASSSETRSKLLDVE
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration (PubMed:29444090, PubMed:30530489). Promotes chronic pain (PubMed:29444090). Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia (PubMed:29444090). {ECO:0000269|PubMed:29444090, ECO:0000269|PubMed:30530489}.
uniprot
proteins
mass_dalton
27397
uniprot
proteins
protein_family
ANT/ATPSC lysine N-methyltransferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29444090
uniprot
proteins
pubmed
30530489
uniprot
proteins
sequence_length
247
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250|UniProtKB:Q6P4H8}; Single-pass membrane protein {ECO:0000255}. Note=Localizes to mitochondrial cristae. {ECO:0000250|UniProtKB:Q6P4H8}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..54; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins