Poln
entrez
272158
canonical
uniprot
Q7TQ07
canonical
ensembl
ENSMUSG00000045102
resolver
ensp
ENSMUSP00000036110
resolver
ensp
ENSMUSP00000143793
resolver
ensp
ENSMUSP00000144578
resolver
enst
ENSMUST00000042954
resolver
enst
ENSMUST00000202409
resolver
enst
ENSMUST00000202638
resolver
genesymbol
Poln
resolver
uniprot
A0A0J9YTQ3
resolver
uniprot
A0A0J9YVA9
resolver
uniprot
A0A0R4J0E3
resolver
uniprot
Q3V0L3
resolver
uniprot_entry
A0A0J9YTQ3_MOUSE
resolver
uniprot_entry
A0A0J9YVA9_MOUSE
resolver
uniprot_entry
A0A0R4J0E3_MOUSE
resolver
uniprot_entry
DPOLN_MOUSE
resolver
uniprot_sec
Q3V0L3
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by ddTTP. {ECO:0000250|UniProtKB:Q7Z5Q5}.
uniprot
proteins
amino_acid_sequence
MENYEACVGFDVCEIPLSAVAQKIMSAMRSGDFMDSRNEGESTNTSKVAKKSSVHYSVLAEHEETQSLGTKNPESLITQTPRGSIELCPQPSITKLTCQLSAGQVQNSISSLGLSSYLIPQCDQEASVLPNMEHKRQHFLKENIGKEDKDNSSLKRKYITCSKSSEKASKHTALEKDTDGTESWPNSRDTRALGERLCDVRYLGDLAKAQLMDALKQAAALVVTLMYKDGSTQLSAKEALTCTVKGIVVLLKSHVGNSTLTLPAHGGALEKDFISEDHCVYIHTEHSPFWDPKQEAHSLFVRNILFWTLRCKCPVVCFNAKDFVRTVLQLYGEDGSWKHVADFVGLDPRVAAWLIDPSDTAPSFEDLVAKHLEKSITVKPSSTFREASRNTLSQNVFMNLKILYDLTMDLCSKLKAYGLWQLFCTLELPLIPILAVMENHKIPVDKEEMERTSALLGARLKELEQEAHFVAGEQFLIMSNNQLREILFGKLKLHLLSQRKHLPRTGLQNQLSTSEAMLNSLQDLHPLPKLILEYRQVHKIKSTFIDGLLAYMKKGSISSTWNQTGTVTGRLSAKHPNIQGISKHPIKISKPWNFKGKEEETVTISPRTLFVSSEGHTFLAADFSQIELRILAHLSGDPELLKLFQESERDDVFSTLTSQWKDIPIERVTHMDREQTKKVVYSVVYGAGKERLAACLGVTVLEATHFLERFLQKYKKIKDFAQTVIGQCHSAGYVTSILGRRRPLPRICAQDQQLRAQAERQAVNFVVQGSAADLCKLAMIRISTAVATSPTLTARLVAQIHDELLFEVEDTQVPEFAALVRRIMESLQQVQTLELQLQVPLKVNLSVGRSWGHLTPLQEILGSA
uniprot
proteins
ec_number
2.7.7.7
uniprot
proteins
function
FUNCTION: DNA polymerase with very low fidelity that catalyzes considerable misincorporation by inserting dTTP opposite a G template, and dGTP opposite a T template. Is the least accurate of the DNA polymerase A family (i.e. POLG, POLN and POLQ). Can perform accurate translesion DNA synthesis (TLS) past a 5S-thymine glycol. Can perform efficient strand displacement past a nick or a gap and gives rise to an amount of product similar to that on non-damaged template. Has no exonuclease activity. Error-prone DNA polymerase that preferentially misincorporates dT regardless of template sequence. May play a role in TLS during interstrand cross-link (ICL) repair. May be involved in TLS when genomic replication is blocked by extremely large major groove DNA lesions. May function in the bypass of some DNA-protein and DNA-DNA cross-links. May have a role in cellular tolerance to DNA cross-linking agents. Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates in FANCD2-mediated repair. Forms a complex with HELQ helicase that participates in homologous recombination (HR) repair and is essential for cellular protection against DNA cross-links. {ECO:0000250|UniProtKB:Q7Z5Q5}.
uniprot
proteins
mass_dalton
96675
uniprot
proteins
protein_family
DNA polymerase type-A family
uniprot
proteins
pubmed
12794064
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
864
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7Z5Q5}.
uniprot
proteins