MID2
entrez
11043
canonical
uniprot
Q9UJV3
canonical
ensembl
ENSG00000080561
resolver
ensp
ENSP00000262843
resolver
ensp
ENSP00000413976
resolver
genesymbol
MID2
resolver
genesymbol_syn
FXY2
resolver
genesymbol_syn
RNF60
resolver
genesymbol_syn
TRIM1
resolver
hgnc
HGNC:7096
resolver
uniprot
A6NEL8
resolver
uniprot
A6PVI5
resolver
uniprot
Q5JYF5
resolver
uniprot
Q6GX22
resolver
uniprot
Q8WWK1
resolver
uniprot
Q9UJR9
resolver
uniprot_entry
Q6GX22_HUMAN
resolver
uniprot_entry
TRIM1_HUMAN
resolver
uniprot_sec
A6NEL8
resolver
uniprot_sec
A6PVI5
resolver
uniprot_sec
Q5JYF5
resolver
uniprot_sec
Q8WWK1
resolver
uniprot_sec
Q9UJR9
resolver
amino_acid_sequence
MGESPASVVLNASGGLFSLKMETLESELTCPICLELFEDPLLLPCAHSLCFSCAHRILVSSCSSGESIEPITAFQCPTCRYVISLNHRGLDGLKRNVTLQNIIDRFQKASVSGPNSPSESRRERTYRPTTAMSSERIACQFCEQDPPRDAVKTCITCEVSYCDRCLRATHPNKKPFTSHRLVEPVPDTHLRGITCLDHENEKVNMYCVSDDQLICALCKLVGRHRDHQVASLNDRFEKLKQTLEMNLTNLVKRNSELENQMAKLIQICQQVEVNTAMHEAKLMEECDELVEIIQQRKQMIAVKIKETKVMKLRKLAQQVANCRQCLERSTVLINQAEHILKENDQARFLQSAKNIAERVAMATASSQVLIPDINFNDAFENFALDFSREKKLLEGLDYLTAPNPPSIREELCTASHDTITVHWISDDEFSISSYELQYTIFTGQANFISKSWCSWGLWPEIRKCKEAVSCSRLAGAPRGLYNSVDSWMIVPNIKQNHYTVHGLQSGTRYIFIVKAINQAGSRNSEPTRLKTNSQPFKLDPKMTHKKLKISNDGLQMEKDESSLKKSHTPERFSGTGCYGAAGNIFIDSGCHYWEVVMGSSTWYAIGIAYKSAPKNEWIGKNASSWVFSRCNSNFVVRHNNKEMLVDVPPHLKRLGVLLDYDNNMLSFYDPANSLHLHTFDVTFILPVCPTFTIWNKSLMILSGLPAPDFIDYPERQECNCRPQESPYVSGMKTCH
uniprot
proteins
disease_involvement
DISEASE: Intellectual developmental disorder, X-linked 101 (XLID101) [MIM:300928]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked forms, while syndromic forms present with associated physical, neurological and/or psychiatric manifestations. XLID101 clinical features include global developmental delay, hyperactivity often with aggressive outbursts, and seizures in some patients. Several affected individuals have long face, prominent ears, and squint or strabismus. {ECO:0000269|PubMed:24115387}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that plays a role in microtubule stabilization (PubMed:35266954). Mediates the 'Lys-48'-linked polyubiquitination of LRRK2 to drive its localization to microtubules and its proteasomal degradation in neurons. This ubiquitination inhibits LRRK2 kinase activation by RAB29 (PubMed:35266954). {ECO:0000269|PubMed:35266954, ECO:0000303|PubMed:24115387}.
uniprot
proteins
mass_dalton
83210
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine and threonine residues (PubMed:11806752). {ECO:0000269|PubMed:11806752}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
10400986
uniprot
proteins
pubmed
10644436
uniprot
proteins
pubmed
11806752
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
24115387
uniprot
proteins
pubmed
35266954
uniprot
proteins
pubmed
40821731
uniprot
proteins
sequence_length
735
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:35266954}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:35266954}. Note=Microtubule-associated. {ECO:0000269|PubMed:35266954}.
uniprot
proteins