Mael
entrez
98558
canonical
uniprot
Q8BVN9
canonical
ensembl
ENSMUSG00000040629
resolver
ensp
ENSMUSP00000045828
resolver
enst
ENSMUST00000038782
resolver
genesymbol
Mael
resolver
uniprot_entry
MAEL_MOUSE
resolver
amino_acid_sequence
MPNRRASRNAYYFFVQEKIPELRRRGLPVARVADAIPYCSADWALLREDEKEKYSEMAREWRAAQGKDSGPSEKQKLVSTPLRRPGMLVPKPSISPPDMSNLSIKSDQALLGGIFYFLNIFSHGELPPHCEQRFLPCEIGCVKYSLQEGIMADFHSFIHPGEIPRGFRFHCQAASDSSHKIPISNFEFGHDQATVLQNLYKFIHPNPGNWPPIYCKSDDRARVNWCLKRMERASEIRQDLELLTVEDLVVGIYQQKFLKEPSKTWVRSLLDVAMWDYSSNTRCKWHEENDILFCALAVCKKIAYCISNSLATLFGIQLTGAHVPLQDYEASNSVTPKMVVLDAGRYQKLRVESPGFCHFNSYNQEQRSNTSTGYYPSGVKISGPHSSVRGRGITRLLESISNSSNNIHRFSSCETSLSPYTPQKDGYKPFSSFS
uniprot
proteins
function
FUNCTION: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage. {ECO:0000269|PubMed:18694567, ECO:0000269|PubMed:20011505}.
uniprot
proteins
mass_dalton
49371
uniprot
proteins
protein_family
Maelstrom family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16787967
uniprot
proteins
pubmed
18694567
uniprot
proteins
pubmed
20011505
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28254886
uniprot
proteins
sequence_length
434
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18694567, ECO:0000269|PubMed:20011505}. Nucleus {ECO:0000269|PubMed:16787967, ECO:0000269|PubMed:18694567}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Recruited to perinuclear nuage during spermatogenesis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs. PIWIL2 is required for its localization to piP-bodies. PubMed:16787967, reported an association with the nuclear XY body, however, PubMed:18694567 showed that it is not the case because the antibody used by PubMed:16787967 still stains the nuclear XY body in spermatocytes lacking Mael. Moreover other antibodies raized against the same epitope used in PubMed:16787967 do not recognize any epitopes on XY chromosomes but show a clear localization to the meiotic nuage. {ECO:0000269|PubMed:16787967, ECO:0000269|PubMed:18694567, ECO:0000269|PubMed:20011505}.
uniprot
proteins