IFIT3
entrez
3437
canonical
uniprot
O14879
canonical
ensembl
ENSG00000119917
resolver
ensp
ENSP00000360876
resolver
ensp
ENSP00000360883
resolver
ensp
ENSP00000504860
resolver
ensp
ENSP00000505300
resolver
ensp
ENSP00000505695
resolver
ensp
ENSP00000505987
resolver
ensp
ENSP00000506309
resolver
ensp
ENSP00000506550
resolver
ensp
ENSP00000506557
resolver
ensp
ENSP00000506643
resolver
enst
ENST00000371811
resolver
enst
ENST00000371818
resolver
enst
ENST00000679536
resolver
enst
ENST00000679583
resolver
enst
ENST00000679781
resolver
enst
ENST00000680037
resolver
enst
ENST00000681178
resolver
enst
ENST00000681207
resolver
enst
ENST00000681277
resolver
enst
ENST00000681376
resolver
genesymbol
IFIT3
resolver
genesymbol_syn
CIG-49
resolver
genesymbol_syn
IFI60
resolver
genesymbol_syn
IFIT4
resolver
genesymbol_syn
ISG60
resolver
hgnc
HGNC:5411
resolver
uniprot
A0A7P0T7D6
resolver
uniprot
Q5T765
resolver
uniprot
Q99634
resolver
uniprot
Q9BSK7
resolver
uniprot_entry
A0A7P0T7D6_HUMAN
resolver
uniprot_entry
IFIT3_HUMAN
resolver
uniprot_entry
Q5T765_HUMAN
resolver
uniprot_sec
Q99634
resolver
uniprot_sec
Q9BSK7
resolver
amino_acid_sequence
MSEVTKNSLEKILPQLKCHFTWNLFKEDSVSRDLEDRVCNQIEFLNTEFKATMYNLLAYIKHLDGNNEAALECLRQAEELIQQEHADQAEIRSLVTWGNYAWVYYHLGRLSDAQIYVDKVKQTCKKFSNPYSIEYSELDCEEGWTQLKCGRNERAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPEKQFSTDVLKQAIELSPDNQYVKVLLGLKLQKMNKEAEGEQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYLYHQIGCCYKAKVRQMQNTGESEASGNKEMIEALKQYAMDYSNKALEKGLNPLNAYSDLAEFLETECYQTPFNKEVPDAEKQQSHQRYCNLQKYNGKSEDTAVQHGLEGLSISKKSTDKEEIKDQPQNVSENLLPQNAPNYWYLQGLIHKQNGDLLQAAKCYEKELGRLLRDAPSGIGSIFLSASELEDGSEEMGQGAVSSSPRELLSNSEQLN
uniprot
proteins
function
FUNCTION: IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Up-regulates CDKN1A/p21 by down-regulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2. {ECO:0000269|PubMed:17050680, ECO:0000269|PubMed:20686046, ECO:0000269|PubMed:21190939, ECO:0000269|PubMed:21642987, ECO:0000269|PubMed:21813773}.
uniprot
proteins
mass_dalton
55985
uniprot
proteins
protein_family
IFIT family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17050680
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
18706081
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20686046
uniprot
proteins
pubmed
20950130
uniprot
proteins
pubmed
21190939
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21642987
uniprot
proteins
pubmed
21813773
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9391139
uniprot
proteins
pubmed
9828129
uniprot
proteins
sequence_length
490
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17050680, ECO:0000269|PubMed:18706081}. Mitochondrion {ECO:0000269|PubMed:21813773}.
uniprot
proteins