Tmem163
entrez
360839
canonical
uniprot
A9CMA6
canonical
ensembl
ENSRNOG00000003769
resolver
ensembl
ENSRNOG00055012797
resolver
ensembl
ENSRNOG00060006180
resolver
ensembl
ENSRNOG00065009674
resolver
ensp
ENSRNOP00000005006
resolver
ensp
ENSRNOP00055017721
resolver
ensp
ENSRNOP00060007591
resolver
ensp
ENSRNOP00065011701
resolver
enst
ENSRNOT00055021878
resolver
enst
ENSRNOT00060010174
resolver
enst
ENSRNOT00065015526
resolver
genesymbol
Tmem163
resolver
genesymbol_syn
Sv31
resolver
uniprot_entry
TM163_RAT
resolver
amino_acid_sequence
MERAPGSERRSPPGPGVPRPPPRGHAPSTAAPAPNPAPLSSSMQPDEERQPRISESGQFSDGFEDRGLLESSTRLKPHEAQNYRKKALWVSWLSIIVTLALAVAAFTVSVMRYSASAFGFAFDAILDVLSSAIVLWRYSNAAAVHSAHREYIACVILGVIFLLSSICIVVKAIHDLSTRLLPEVDDFLFSVSILSGILCSVLAVLKFMLGKVLTSRALITDGFNSLVGGVMGFSILLSAEVFKHNAAVWYLDGSIGVLIGLTIFAYGVKLLIDMVPRVRQTRHYEMFE
uniprot
proteins
function
FUNCTION: Zinc ion transporter that mediates zinc efflux and plays a crucial role in intracellular zinc homeostasis (By similarity). Binds the divalent cations Zn(2+), Ni(2+), and to a minor extent Cu(2+) (PubMed:21668449). Is a functional modulator of P2X purinoceptors, including P2RX1, P2RX3, P2RX4 and P2RX7 (By similarity). Plays a role in central nervous system development and is required for myelination, and survival and proliferation of oligodendrocytes (By similarity). {ECO:0000250|UniProtKB:B0UY98, ECO:0000250|UniProtKB:Q8TC26, ECO:0000269|PubMed:21668449}.
uniprot
proteins
mass_dalton
31344
uniprot
proteins
protein_family
TMEM163 family
uniprot
proteins
pubmed
17623043
uniprot
proteins
pubmed
18064521
uniprot
proteins
pubmed
20053882
uniprot
proteins
pubmed
21668449
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
288
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:17623043}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:21668449}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000250|UniProtKB:Q8TC26}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:Q8TC26}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q8TC26}; Multi-pass membrane protein {ECO:0000255}. Note=Glutamatergic synaptic vesicles. {ECO:0000269|PubMed:17623043}.
uniprot
proteins
transmembrane_region
TRANSMEM 88..108; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 116..136; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 150..170; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 187..207; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 217..237; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 255..275; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins