AJAP1
entrez
55966
canonical
uniprot
Q9UKB5
canonical
ensembl
ENSG00000196581
resolver
ensp
ENSP00000367432
resolver
ensp
ENSP00000367433
resolver
ensp
ENSP00000550808
resolver
ensp
ENSP00000793371
resolver
enst
ENST00000378190
resolver
enst
ENST00000378191
resolver
enst
ENST00000880749
resolver
genesymbol
AJAP1
resolver
genesymbol_syn
MOT8
resolver
genesymbol_syn
SHREW1
resolver
hgnc
HGNC:30801
resolver
uniprot
Q9Y229
resolver
uniprot_entry
AJAP1_HUMAN
resolver
uniprot_sec
Q9Y229
resolver
amino_acid_sequence
MWIQQLLGLSSMSIRWPGRPLGSHAWILIAMFQLAVDLPACEALGPGPEFWLLPRSPPRPPRLWSFRSGQPARVPAPVWSPRPPRVERIHGQMQMPRARRAHRPRDQAAALVPKAGLAKPPAAAKSSPSLASSSSSSSSAVAGGAPEQQALLRRGKRHLQGDGLSSFDSRGSRPTTETEFIAWGPTGDEEALESNTFPGVYGPTTVSILQTRKTTVAATTTTTTTATPMTLQTKGFTESLDPRRRIPGGVSTTEPSTSPSNNGEVTQPPRILGEASGLAVHQIITITVSLIMVIAALITTLVLKNCCAQSGNTRRNSHQRKTNQQEESCQNLTDFPSARVPSSLDIFTAYNETLQCSHECVRASVPVYTDETLHSTTGEYKSTFNGNRPSSSDRHLIPVAFVSEKWFEISC
uniprot
proteins
function
FUNCTION: Plays a role in cell adhesion and cell migration. {ECO:0000269|PubMed:16410724, ECO:0000269|PubMed:17267690}.
uniprot
proteins
mass_dalton
44536
uniprot
proteins
mutagenesis
MUTAGEN 303; /note="L->A: Predominantly localized to the apical membrane."; /evidence="ECO:0000269|PubMed:16707570"; MUTAGEN 304; /note="K->A: No effect on membrane localization."; /evidence="ECO:0000269|PubMed:16707570"; MUTAGEN 350; /note="Y->A: Predominantly localized to the apical membrane."; /evidence="ECO:0000269|PubMed:16707570"; MUTAGEN 359; /note="E->A: No effect on membrane localization."; /evidence="ECO:0000269|PubMed:16707570"; MUTAGEN 368; /note="Y->A: Predominantly localized to the apical membrane."; /evidence="ECO:0000269|PubMed:16707570"; MUTAGEN 380; /note="Y->A: Predominantly localized to the apical membrane."; /evidence="ECO:0000269|PubMed:16707570"; MUTAGEN 396..397; /note="LI->HV: Predominantly localized to the apical membrane."; /evidence="ECO:0000269|PubMed:16707570"; MUTAGEN 396; /note="L->A: Predominantly localized to the apical membrane."; /evidence="ECO:0000269|PubMed:16707570
uniprot
proteins
post_translational_modification
PTM: Thr-237 and Ser-239 may be phosphorylated; however as this position is probably extracellular, the in vivo relevance is not proven.
uniprot
proteins
pubmed
14595118
uniprot
proteins
pubmed
16410724
uniprot
proteins
pubmed
16707570
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17267690
uniprot
proteins
pubmed
18485053
uniprot
proteins
pubmed
18648515
uniprot
proteins
sequence_length
411
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:16707570}; Single-pass type I membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:16707570}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, adherens junction {ECO:0000269|PubMed:14595118}. Note=Mainly basolateral (PubMed:16707570). Localization is mediated by AP1M2 (PubMed:16707570). {ECO:0000269|PubMed:16707570}.
uniprot
proteins
transmembrane_region
TRANSMEM 283..303; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins