GSTA1
entrez
2938
canonical
uniprot
P08263
canonical
ensembl
ENSG00000243955
resolver
ensp
ENSP00000335620
resolver
ensp
ENSP00000537688
resolver
ensp
ENSP00000537689
resolver
ensp
ENSP00000537690
resolver
ensp
ENSP00000537694
resolver
ensp
ENSP00000537695
resolver
ensp
ENSP00000653172
resolver
enst
ENST00000334575
resolver
enst
ENST00000867629
resolver
enst
ENST00000867630
resolver
enst
ENST00000867631
resolver
enst
ENST00000867635
resolver
enst
ENST00000867636
resolver
genesymbol
GSTA1
resolver
hgnc
HGNC:4626
resolver
uniprot
A0A140VJK4
resolver
uniprot
B7Z1F9
resolver
uniprot
Q14750
resolver
uniprot
Q5GHF8
resolver
uniprot
Q5SZC1
resolver
uniprot_entry
A0A140VJK4_HUMAN
resolver
uniprot_entry
B7Z1F9_HUMAN
resolver
uniprot_entry
GSTA1_HUMAN
resolver
uniprot_sec
Q14750
resolver
uniprot_sec
Q5GHF8
resolver
uniprot_sec
Q5SZC1
resolver
activity_regulation
ACTIVITY REGULATION: The isomerase activity is inhibited by S-methylglutathione (GSMe). {ECO:0000269|PubMed:11152686}.
uniprot
proteins
amino_acid_sequence
MAEKPKLHYFNARGRMESTRWLLAAAGVEFEEKFIKSAEDLDKLRNDGYLMFQQVPMVEIDGMKLVQTRAILNYIASKYNLYGKDIKERALIDMYIEGIADLGEMILLLPVCPPEEKDAKLALIKEKIKNRYFPAFEKVLKSHGQDYLVGNKLSRADIHLVELLYYVEELDSSLISSFPLLKALKTRISNLPTVKKFLQPGSPRKPPMDEKSLEEARKIFRF
uniprot
proteins
ec_number
1.11.1.-
uniprot
proteins
ec_number
2.5.1.18
uniprot
proteins
ec_number
5.3.3.-
uniprot
proteins
function
FUNCTION: Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (Probable). Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis (PubMed:11152686). Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid (PubMed:16624487). {ECO:0000269|PubMed:11152686, ECO:0000269|PubMed:16624487, ECO:0000269|PubMed:9084911, ECO:0000305|PubMed:20606271}.
uniprot
proteins
mass_dalton
25631
uniprot
proteins
mutagenesis
MUTAGEN 9; /note="Y->F: Decreased isomerase activity."; /evidence="ECO:0000269|PubMed:11152686"; MUTAGEN 71; /note="I->A,V: No significant effect on enzyme activity. Reduces protein stability."; /evidence="ECO:0000269|PubMed:20606271"; MUTAGEN 216; /note="A->H: Confers ability to hydrolyze S-glutathionyl benzoate to glutathione and benzoic acid."; /evidence="ECO:0000269|PubMed:15333749
uniprot
proteins
protein_family
Alpha family
uniprot
proteins
protein_family
GST superfamily
uniprot
proteins
pubmed
11152686
uniprot
proteins
pubmed
12211029
uniprot
proteins
pubmed
1330133
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15333749
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15893769
uniprot
proteins
pubmed
16421451
uniprot
proteins
pubmed
16624487
uniprot
proteins
pubmed
1731620
uniprot
proteins
pubmed
19618965
uniprot
proteins
pubmed
2018473
uniprot
proteins
pubmed
20606271
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2604726
uniprot
proteins
pubmed
3031680
uniprot
proteins
pubmed
3036131
uniprot
proteins
pubmed
3138230
uniprot
proteins
pubmed
3678589
uniprot
proteins
pubmed
3800996
uniprot
proteins
pubmed
8331657
uniprot
proteins
pubmed
8431482
uniprot
proteins
pubmed
8591048
uniprot
proteins
pubmed
9084911
uniprot
proteins
sequence_length
222
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins