IGF1
entrez
3479
canonical
uniprot
P05019
canonical
ensembl
ENSG00000017427
resolver
ensp
ENSP00000302665
resolver
ensp
ENSP00000337612
resolver
ensp
ENSP00000376638
resolver
ensp
ENSP00000416811
resolver
ensp
ENSP00000494228
resolver
ensp
ENSP00000674451
resolver
genesymbol
IGF-I
resolver
genesymbol
IGF1
resolver
genesymbol_syn
IBP1
resolver
genesymbol_syn
IGF-1
resolver
hgnc
HGNC:5464
resolver
uniprot
B2RWM7
resolver
uniprot
E9PD02
resolver
uniprot
P01343
resolver
uniprot
Q13429
resolver
uniprot
Q14620
resolver
uniprot
Q59GC5
resolver
uniprot
Q5U743
resolver
uniprot_entry
IGF1_HUMAN
resolver
uniprot_entry
Q13429_HUMAN
resolver
uniprot_entry
Q59GC5_HUMAN
resolver
uniprot_entry
Q5U743_HUMAN
resolver
uniprot_sec
B2RWM7
resolver
uniprot_sec
E9PD02
resolver
uniprot_sec
P01343
resolver
uniprot_sec
Q14620
resolver
amino_acid_sequence
MGKISSLPTQLFKCCFCDFLKVKMHTMSSSHLFYLALCLLTFTSSATAGPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSARSVRAQRHTDMPKTQKYQPPSTNKNTKSQRRKGWPKTHPGGEQKEGTEASLQIRGKKKEQRREIGSRNAECRGKKGK
uniprot
proteins
disease_involvement
DISEASE: Insulin-like growth factor I deficiency (IGF1D) [MIM:608747]: An autosomal recessive disorder characterized by growth retardation, sensorineural deafness and intellectual disability. {ECO:0000269|PubMed:8857020}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (PubMed:21076856, PubMed:24132240). Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (By similarity). Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:19578119, PubMed:22351760, PubMed:23243309, PubMed:23696648). As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). {ECO:0000250|UniProtKB:P05017, ECO:0000250|UniProtKB:P08025, ECO:0000269|PubMed:19578119, ECO:0000269|PubMed:21076856, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:23243309, ECO:0000269|PubMed:23696648, ECO:0000269|PubMed:24132240}.
uniprot
proteins
mass_dalton
21841
uniprot
proteins
mutagenesis
MUTAGEN 84; /note="R->E: Dominant-negative mutant, no effect on IGFR1-binding, defective in integrin-binding and the formation of ternary complex with integrins and IGFR1, defective in inducing IGF1 signaling and cell proliferation, and suppresses activation of IGF1R by insulin and tumorigenesis in vivo; when associated with E-85."; /evidence="ECO:0000269|PubMed:19578119, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:23243309, ECO:0000269|PubMed:23696648"; MUTAGEN 85; /note="R->E: Dominant-negative mutant, no effect on IGFR1-binding, defective in integrin-binding and the formation of ternary complex with integrins and IGFR1, defective in inducing IGF1 signaling and cell proliferation, and suppresses activation of IGF1R by insulin and tumorigenesis in vivo; when associated with E-84."; /evidence="ECO:0000269|PubMed:19578119, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:23243309, ECO:0000269|PubMed:23696648
uniprot
proteins
protein_family
Insulin family
uniprot
proteins
pubmed
10391209
uniprot
proteins
pubmed
1319992
uniprot
proteins
pubmed
1372070
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
19578119
uniprot
proteins
pubmed
2018498
uniprot
proteins
pubmed
2036417
uniprot
proteins
pubmed
2082190
uniprot
proteins
pubmed
20881139
uniprot
proteins
pubmed
21076856
uniprot
proteins
pubmed
22351760
uniprot
proteins
pubmed
23243309
uniprot
proteins
pubmed
23696648
uniprot
proteins
pubmed
24132240
uniprot
proteins
pubmed
24389050
uniprot
proteins
pubmed
2935423
uniprot
proteins
pubmed
2937782
uniprot
proteins
pubmed
3002851
uniprot
proteins
pubmed
3242681
uniprot
proteins
pubmed
3455760
uniprot
proteins
pubmed
35907924
uniprot
proteins
pubmed
6189745
uniprot
proteins
pubmed
632300
uniprot
proteins
pubmed
6358902
uniprot
proteins
pubmed
6382022
uniprot
proteins
pubmed
8495408
uniprot
proteins
pubmed
8857020
uniprot
proteins
sequence_length
195
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P05017}.
uniprot
proteins