ANO9
entrez
338440
canonical
uniprot
A1A5B4
canonical
ensembl
ENSG00000185101
resolver
ensp
ENSP00000332788
resolver
genesymbol
ANO9
resolver
genesymbol_syn
PIG5
resolver
genesymbol_syn
TMEM16J
resolver
genesymbol_syn
TP53I5
resolver
hgnc
HGNC:20679
resolver
uniprot
B3KUC4
resolver
uniprot
B4E134
resolver
uniprot
Q8TEN4
resolver
uniprot_entry
ANO9_HUMAN
resolver
uniprot_sec
B3KUC4
resolver
uniprot_sec
B4E134
resolver
uniprot_sec
Q8TEN4
resolver
activity_regulation
ACTIVITY REGULATION: Cation channel activity is activated via phosphorylation on serine residues by cAMP-dependent protein kinase A (PKA). {ECO:0000269|PubMed:29604966}.
uniprot
proteins
amino_acid_sequence
MQGEESLRILVEPEGDSFPLMEISTCETEASEQWDYVLVAQRHTQRDPRQARQQQFLEELRRKGFHIKVIRDQKQVFFGIRADNSVFGLYRTLLLEPEGPAPHAELAAPTTIPVTTSLRIRIVNFVVMNNKTSAGETFEDLMKDGVFEARFPLHKGEGRLKKTWARWRHMFREQPVDEIRNYFGEKVALYFVWLGWYTYMLVPAALTGLLVFLSGFSLFEASQISKEICEAHDILMCPLGDHSRRYQRLSETCTFAKLTHLFDNDGTVVFAIFMALWATVFLEIWKRQRARVVLHWDLYVWDEEQEEMALQLINCPDYKLRPYQHSYLRSTVILVLTLLMICLMIGMAHVLVVYRVLASALFSSSAVPFLEEQVTTAVVVTGALVHYVTIIIMTKINRCVALKLCDFEMPRTFSERESRFTIRFFTLQFFTHFSSLIYIAFILGRINGHPGKSTRLAGLWKLEECHASGCMMDLFVQMAIIMGLKQTLSNCVEYLVPWVTHKCRSLRASESGHLPRDPELRDWRRNYLLNPVNTFSLFDEFMEMMIQYGFTTIFVAAFPLAPLLALFSNLVEIRLDAIKMVWLQRRLVPRKAKDIGTWLQVLETIGVLAVIANGMVIAFTSEFIPRVVYKYRYSPCLKEGNSTVDCLKGYVNHSLSVFHTKDFQDPDGIEGSENVTLCRYRDYRNPPDYNFSEQFWFLLAIRLAFVILFEHVALCIKLIAAWFVPDIPQSVKNKVLEVKYQRLREKMWHGRQRLGGVGAGSRPPMPAHPTPASIFSARSTDV
uniprot
proteins
function
FUNCTION: PKA-activated nonselective cation channel (PubMed:29604966). Discriminates poorly among cations but is more permeable to Ca(2+) ions than to monovalent cations (By similarity). Acts as a calcium-activated calcium permeable channel which may operate as a endoplasmic reticulum (ER) Ca(2+)-leak channel, reducing the loading of the ER Ca(2+) store (PubMed:36520003). Regulates intracellular Ca2+ signals, ion channel activity, and cytokine release in the renal tissue (PubMed:36520003). Plays an important role in olfaction, amplifying cAMP-evoked cyclic nucleotide-gated (CNG) channel currents in the olfactory sensory neurons (By similarity). Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:22178883). Can inhibit the activity of ANO1 (PubMed:20056604, PubMed:22946059). {ECO:0000250|UniProtKB:P86044, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22178883, ECO:0000269|PubMed:22946059, ECO:0000269|PubMed:29604966, ECO:0000269|PubMed:36520003}.
uniprot
proteins
mass_dalton
90333
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine residues by cAMP-dependent protein kinase A (PKA) which is essential for activation of its cation channel activity. {ECO:0000269|PubMed:29604966}.
uniprot
proteins
protein_family
Anoctamin family
uniprot
proteins
pubmed
12693554
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
20056604
uniprot
proteins
pubmed
21607626
uniprot
proteins
pubmed
21642943
uniprot
proteins
pubmed
21984732
uniprot
proteins
pubmed
22178883
uniprot
proteins
pubmed
22302790
uniprot
proteins
pubmed
22946059
uniprot
proteins
pubmed
29604966
uniprot
proteins
pubmed
36330924
uniprot
proteins
pubmed
36520003
uniprot
proteins
sequence_length
782
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22946059, ECO:0000269|PubMed:29604966}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum {ECO:0000269|PubMed:36520003}. Note=Shows predominantly an intracellular localization with a weak expression in the cell membrane.
uniprot
proteins
transmembrane_region
TRANSMEM 199..219; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 265..285; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 332..352; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 374..394; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 424..444; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 553..573; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 605..625; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 704..724; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins