Cdyl
entrez
361237
canonical
uniprot
Q6AYK9
canonical
ensembl
ENSRNOG00000032215
resolver
ensembl
ENSRNOG00055013448
resolver
ensembl
ENSRNOG00060009819
resolver
ensembl
ENSRNOG00065008216
resolver
ensp
ENSRNOP00000048651
resolver
ensp
ENSRNOP00000078650
resolver
ensp
ENSRNOP00000080331
resolver
ensp
ENSRNOP00000095115
resolver
ensp
ENSRNOP00000106192
resolver
enst
ENSRNOT00000048757
resolver
enst
ENSRNOT00000106207
resolver
enst
ENSRNOT00000119808
resolver
genesymbol
Cdyl
resolver
uniprot
A0A8I6G3K3
resolver
uniprot
A0A8I6G6F9
resolver
uniprot
A0A8L2QNJ4
resolver
uniprot_entry
A0A8I6G3K3_RAT
resolver
uniprot_entry
A0A8I6G6F9_RAT
resolver
uniprot_entry
A0A8L2QNJ4_RAT
resolver
uniprot_entry
CDYL_RAT
resolver
amino_acid_sequence
MGLGSSQPSTKEAEPCTLQEKEEHPVDDTRQQNNAVPATVSDPDQVSPAVQDAETQVESIVDKRKNKKGKTEYLVRWKGYDSEDDTWEPEQHLVNCEEYIHDFNRRHNERQKEGTLARANRASPSNARKQISRSTHSALSKTNPKALVVGKDHESKTNQLLATSQKFRKNTAPSLANRKNMDLAKSGIKILVPKSPIKGRTSIDGFHGESPEKLDQGAEDTVTPEVTAEKPTGALLGPGAERARMGSRPRIHSLVPQVSGPVTAAMATTLAVNGKGTSPFMDALTANGTVTIQTSVTGVTAGKRKFIDDRRDQPFDKRLRFSVRQTESAYRYRDIVVRKQDGFTHILLSTKSSENNSLNPEVMKEVQSALSTAAADDSKLVLLSAVGSVFCCGLDFIYFIRRLTDDRKRESTKMAEAIRNFVNTFIQFKKPIIVAVNGPAIGLGASILPLCDVVWANEKAWFQTPYTTFGQSPDGCSTVMFPKIMGGASANEMLLSGRKLTAQEACGKGLVSQVFWPGTFTQEVMVRIKELASCNPIVLEESKALVRCNMKMELEQANERECDALKKIWGSAQGMDSMLKYLQRKIDEF
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
ec_number
4.2.1.-
uniprot
proteins
function
FUNCTION: [Isoform 2]: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape. Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes. Acts as a corepressor for REST by facilitating histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression (By similarity). Involved in X chromosome inactivation in females: recruited to Xist RNA-coated X chromosome and facilitates propagation of H3K9me2 by anchoring EHMT2 (By similarity). Promotes EZH2 accumulation and H3K27me3 methylation at DNA double strand breaks (DSBs), thereby facilitating transcriptional repression at sites of DNA damage and homology-directed repair of DSBs (By similarity). Required for neuronal migration during brain development by repressing expression of RHOA (By similarity). By repressing the expression of SCN8A, contributes to the inhibition of intrinsic neuronal excitability and epileptogenesis (PubMed:28842554). In addition to acting as a chromatin reader, acts as a hydro-lyase. Shows crotonyl-coA hydratase activity by mediating the conversion of crotonyl-CoA ((2E)-butenoyl-CoA) to beta-hydroxybutyryl-CoA (3-hydroxybutanoyl-CoA), thereby acting as a negative regulator of histone crotonylation (By similarity). Histone crotonylation is required during spermatogenesis; down-regulation of histone crotonylation by CDYL regulates the reactivation of sex chromosome-linked genes in round spermatids and histone replacement in elongating spermatids (By similarity). By regulating histone crotonylation and trimethylation of H3K27, may be involved in stress-induced depression-like behaviors, possibly by regulating VGF expression (By similarity). Displays acetyltransferase activity toward tubulin in vitro; such activity is however unsure in vivo and additional evidence would be required to confirm this result (PubMed:28681565). {ECO:0000250|UniProtKB:Q9WTK2, ECO:0000250|UniProtKB:Q9Y232, ECO:0000269|PubMed:28842554, ECO:0000305|PubMed:28681565}.; FUNCTION: [Isoform 1]: Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the presence of a N-terminal extension that inactivates the chromo domain. {ECO:0000250|UniProtKB:Q9Y232}.
uniprot
proteins
mass_dalton
65031
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
28681565
uniprot
proteins
pubmed
28842554
uniprot
proteins
pubmed
30665597
uniprot
proteins
sequence_length
589
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000250|UniProtKB:Q9Y232}. Chromosome {ECO:0000250|UniProtKB:Q9Y232}. Note=Recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) on chromatin. Multimerization is required for chromatin-binding. Recruited to sites of DNA double strand breaks in a PARP1-dependent fashion (By similarity). {ECO:0000250|UniProtKB:Q9Y232}.
uniprot
proteins