Alg12
entrez
223774
canonical
uniprot
Q8VDB2
canonical
ensembl
ENSMUSG00000035845
resolver
ensp
ENSMUSP00000043480
resolver
ensp
ENSMUSP00000123935
resolver
ensp
ENSMUSP00000323970
resolver
ensp
ENSMUSP00000323972
resolver
ensp
ENSMUSP00000323978
resolver
enst
ENSMUST00000043087
resolver
enst
ENSMUST00000162183
resolver
genesymbol
Alg12
resolver
uniprot
F7B8U5
resolver
uniprot
Q3UQK8
resolver
uniprot
Q8VCA2
resolver
uniprot_entry
ALG12_MOUSE
resolver
uniprot_entry
F7B8U5_MOUSE
resolver
uniprot_entry
Q8VCA2_MOUSE
resolver
uniprot_sec
Q3UQK8
resolver
amino_acid_sequence
MAGKKSSGKRSWPLLGLLVTVATIHLVICPYTKVEESFNLQATHDLLYHQLDIDKYDHHEFPGVVPRTFLGPLVIAAFSSPVVYVLSLLEVSKFYSQLIVRGVLGLGVISGLWTLQKEVRQQFGATVAVMFCWISATQFHLMFYCTRTLPNVLALAVVLPALTAWLQRRWALFVWLSAFVIIGFRAELAMLLGIALLLTLYQRRLTVARVLRHAIPAGLLCLGLTVAVDSYFWRYLVWPEGVVLWYNTVLNKSSNWGTSPLLWYFYSALPRGLGCSLLFIPLGAVDRRTYALALPSLGFVALYSLLPHKELRFIIYTFPVLNIMAARGCTYILNKKSWPYKVRAMLVTGHILVNVAYTATSLYVSHFNYPGGVAMQQLHELVPPQTDVLLHIDVAAAQTGVSRFLQVNDDWRYDKSEDVGAAAMLNYTHILMEAVPGHPALYRDTHRVLASIEGTTGISLNLMKLPPFDVNLQTKLVLLERLLRPA
uniprot
proteins
ec_number
2.4.1.260
uniprot
proteins
function
FUNCTION: Mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the eighth mannose residue in an alpha-1,6 linkage onto Man(7)GlcNAc(2)-PP-dolichol to produce Man(8)GlcNAc(2)-PP-dolichol. {ECO:0000250|UniProtKB:Q9BV10}.
uniprot
proteins
mass_dalton
54543
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:Q9BV10}.
uniprot
proteins
protein_family
Glycosyltransferase 22 family
uniprot
proteins
pubmed
12200473
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
486
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9BV10}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 69..89; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 94..114; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 123..143; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 146..166; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 178..198; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 213..233; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 265..285; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 291..311; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 313..333; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 344..364; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins