Nradd
entrez
67169
canonical
uniprot
Q8CJ26
canonical
ensembl
ENSMUSG00000032491
resolver
ensp
ENSMUSP00000035069
resolver
enst
ENSMUST00000035069
resolver
genesymbol
Nradd
resolver
uniprot
Q3TVC1
resolver
uniprot_entry
NRADD_MOUSE
resolver
uniprot_sec
Q3TVC1
resolver
amino_acid_sequence
MLYNVSKGVVYSDTALQGQDGDREGMWVGAGGALAPNTSSLFPPEPPGASSNIIPVYCALLATVILGLLAYVAFKCWRSHKQRQQLAKARTVELGDPDRDQRRGDSNVFVDSPPSLEPCIPSQGPHPDLGCQLYLHIPQQQQEEVQRLLMMGEPAKGWQELAGHLGYQAEAVETMACDQMPAYTLLRNWAAQEGNRATLRVLEDALAAIGREDVVQVLSSPAESSSVV
uniprot
proteins
function
FUNCTION: Modulates NTRK1 signaling. Can activate several intracellular signaling pathways, leading to activation of JUN. Promotes apoptosis. Promotes translocation of SORT1 to the cell membrane, and thereby hinders lysosomal degradation of SOTR1 and promotes its interaction with NGFR. {ECO:0000269|PubMed:12728256, ECO:0000269|PubMed:12843241, ECO:0000269|PubMed:19407813}.
uniprot
proteins
mass_dalton
24727
uniprot
proteins
pubmed
12728256
uniprot
proteins
pubmed
12843241
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18624909
uniprot
proteins
pubmed
19407813
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19656770
uniprot
proteins
sequence_length
228
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type III membrane protein. Nucleus. Note=Proteolytic processing gives rise to an intracellular domain that translocates to the nucleus.
uniprot
proteins
transmembrane_region
TRANSMEM 53..73; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins