Sdhaf4
entrez
68002
canonical
uniprot
Q8BTE0
canonical
ensembl
ENSMUSG00000026154
resolver
ensp
ENSMUSP00000027338
resolver
enst
ENSMUST00000027338
resolver
genesymbol
Sdhaf4
resolver
uniprot
Q9CQN5
resolver
uniprot
Q9D537
resolver
uniprot_entry
SDHF4_MOUSE
resolver
uniprot_sec
Q9CQN5
resolver
uniprot_sec
Q9D537
resolver
amino_acid_sequence
MVSTTLSVSRMTFVWRAARPSLLNHSLRKMSYQEGKPEPAKQALKKSKLPLGRFDSLEDSPEEREPLQKFPDDVNPVTKEKGGPKGPEPTRYGDWERKGRCIDF
uniprot
proteins
function
FUNCTION: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954416). Binds to the flavoprotein subunit Sdha in its FAD-bound form, blocking the generation of excess reactive oxygen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit Sdhb into the SDH catalytic dimer (By similarity). {ECO:0000250|UniProtKB:P38345, ECO:0000269|PubMed:24954416}.
uniprot
proteins
mass_dalton
11889
uniprot
proteins
protein_family
SDHAF4 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
24954416
uniprot
proteins
sequence_length
104
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:P38345}.
uniprot
proteins