SLC25A45
entrez
283130
canonical
uniprot
Q8N413
canonical
ensembl
ENSG00000162241
resolver
ensp
ENSP00000294187
resolver
ensp
ENSP00000381782
resolver
ensp
ENSP00000431769
resolver
ensp
ENSP00000435489
resolver
ensp
ENSP00000435547
resolver
enst
ENST00000526432
resolver
genesymbol
SLC25A45
resolver
hgnc
HGNC:27442
resolver
uniprot
E9PJQ3
resolver
uniprot
Q6PL49
resolver
uniprot
Q8IW29
resolver
uniprot_entry
E9PJQ3_HUMAN
resolver
uniprot_entry
S2545_HUMAN
resolver
uniprot_sec
Q6PL49
resolver
uniprot_sec
Q8IW29
resolver
amino_acid_sequence
MPVEEFVAGWISGALGLVLGHPFDTVKVRLQTQTTYRGIVDCMVKIYRHESLLGFFKGMSFPIASIAVVNSVLFGVYSNTLLVLTATSHQERRAQPPSYMHIFLAGCTGGFLQAYCLAPFDLIKVRLQNQTEPRAQPGSPPPRYQGPVHCAASIFREEGPRGLFRGAWALTLRDTPTVGIYFITYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWVAATPLDMIKSRMQMDGLRRRVYQGMLDCMVSSIRQEGLGVFFRGVTINSARAFPVNAVTFLSYEYLLRWWG
uniprot
proteins
function
FUNCTION: Mitochondrial transporter that specifically mediates the mitochondrial uptake of dimethylarginine and trimethyllysine amino acids, and which is required for carnitine biosynthesis (PubMed:41075780, PubMed:41075794). Involved in carnitine biosynthesis by mediating the mitochondrial import of trimethyllysine, a precursor for carnitine biosynthesis (PubMed:41075780, PubMed:41075794). Transports both symmetric and asymmetric dimethylarginine (PubMed:41075794). Does not transport unmethylated arginine and lysine (PubMed:41075794). {ECO:0000269|PubMed:41075780, ECO:0000269|PubMed:41075794}.
uniprot
proteins
mass_dalton
31906
uniprot
proteins
mutagenesis
MUTAGEN 268; /note="R->A: Impaired transporter activity, leading to decreased synthesis of deoxycarnitine accumulation of dimethylarginine."; /evidence="ECO:0000269|PubMed:41075794
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved by m-AAA protease (AFG3L2), leading to its degradation. {ECO:0000269|PubMed:41075794}.
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16949250
uniprot
proteins
pubmed
41075780
uniprot
proteins
pubmed
41075794
uniprot
proteins
sequence_length
288
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:41075794}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 6..26; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 63..83; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 100..120; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 166..186; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 202..222; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 266..286; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins