Fam170a
entrez
225497
canonical
uniprot
Q66LM6
canonical
ensembl
ENSMUSG00000035420
resolver
ensp
ENSMUSP00000035910
resolver
ensp
ENSMUSP00000158194
resolver
ensp
ENSMUSP00000354943
resolver
enst
ENSMUST00000238078
resolver
genesymbol
Fam170a
resolver
genesymbol_syn
Gm93
resolver
genesymbol_syn
Znfd
resolver
uniprot
A0A494BAQ9
resolver
uniprot
B2RW56
resolver
uniprot
Q66LM7
resolver
uniprot_entry
A0A494BAQ9_MOUSE
resolver
uniprot_entry
F170A_MOUSE
resolver
uniprot_sec
B2RW56
resolver
uniprot_sec
Q66LM7
resolver
amino_acid_sequence
MKRRQKRKHLEIEESKEAGISKSQEDISHPESTGVPKAQSPGVGEVSSASEYFSCVSSPQKLIHRSKGTWKLLQDSSKPRSPLDQVPEGEATTAPSQQASSSCPSYKTCVSSLCMNKEERGMKIYYMQVQMKKGVAISWDTKETSESLEKQPRMEEATLPEGVWVGTPPSDVSTRNLLSDSEPIGEEKEHEEKPESDSPPGSPAVEERPRAKTPDWLVTMENGFRCMACCRVFATMESLQEHVQYGIREGFSCHVFHLTMAQLIGSMESESTQEEEEDHTEETEKPKEEKAEEQQPTEEDVGMKKPWSQCPGCVFDSPKDRRRRKDHCDNSGS
uniprot
proteins
function
FUNCTION: Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes (PubMed:22231842). Binds to heat shock promoter elements (HSE) (PubMed:22231842). Necessary for normal sperm head morphology, efficient spermiation, and sperm progressive motility (PubMed:32588889). Plays a crucial role in sperm chromatin remodeling by promoting the nuclear translocation and deubiquitinating activity of USP7 on histone H2A and H2B variants. This ensures the timely removal of core histones, proper expression and degradation of transition proteins, and efficient incorporation of protamines during spermiogenesis (PubMed:39868537). {ECO:0000269|PubMed:22231842, ECO:0000269|PubMed:32588889, ECO:0000269|PubMed:39868537}.
uniprot
proteins
mass_dalton
37392
uniprot
proteins
protein_family
FAM170 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22231842
uniprot
proteins
pubmed
32588889
uniprot
proteins
pubmed
39868537
uniprot
proteins
sequence_length
333
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22231842, ECO:0000269|PubMed:32588889, ECO:0000269|PubMed:39868537}.
uniprot
proteins