Icam2
entrez
15896
canonical
uniprot
P35330
canonical
ensembl
ENSMUSG00000001029
resolver
ensp
ENSMUSP00000001055
resolver
ensp
ENSMUSP00000313497
resolver
ensp
ENSMUSP00000363362
resolver
enst
ENSMUST00000001055
resolver
genesymbol
Icam2
resolver
uniprot
Q9D8Q4
resolver
uniprot_entry
ICAM2_MOUSE
resolver
uniprot_sec
Q9D8Q4
resolver
amino_acid_sequence
MSSFACWSLSLLILFYSPGSGEKAFEVYIWSEKQIVEATESWKINCSTNCAAPDMGGLETPTNKIMLEEHPQGKWKQFLVSNVSKDTVFFCHFTCSGKQHSESLNIRVYQPPAQVTLKLQPPRVFVGEDFTIECTVSPVQPLERLTLSLLRGRETLKNQTFGGAETVPQEATATFNSTALKKDGLNFSCQAELDLRPHGGYIIRSISEYQILEVYEPMQDNQMVIIIVVVSILLFLFVTSVLLCFIFGQHWHRRRTGTYGVLAAWRRLPRAFRARPV
uniprot
proteins
function
FUNCTION: Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring leukocyte cell-cell adhesion on resting cells (PubMed:1401904). Also endothelial blood vessels receptor ligand of dendritic cell (DC) CD209 signaling receptor that mediates triggering transendothelial migration of DC presursors from blood into peripheral tissues and, subsequently, into lymphoid tissues. Mediates adhesive interactions important for antigen presentation, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance (By similarity). {ECO:0000250|UniProtKB:P13598, ECO:0000269|PubMed:1401904}.
uniprot
proteins
mass_dalton
31390
uniprot
proteins
mutagenesis
MUTAGEN 253..255; /note="RRR->GGA: Loss of interaction with EZR, MSN and RDX and co-localization to microvilli."; /evidence="ECO:0000269|PubMed:9472040
uniprot
proteins
protein_family
ICAM family
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
1401904
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9472040
uniprot
proteins
sequence_length
277
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P13598}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, microvillus {ECO:0000269|PubMed:9472040}. Note=Co-localizes with RDX, EZR and MSN in microvilli. {ECO:0000269|PubMed:9472040}.
uniprot
proteins
transmembrane_region
TRANSMEM 223..247; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins