HAPSTR1
entrez
29035
canonical
uniprot
Q14CZ0
canonical
ensembl
ENSG00000182831
resolver
ensp
ENSP00000331720
resolver
ensp
ENSP00000796212
resolver
genesymbol
HAPSTR1
resolver
genesymbol_syn
C16orf72
resolver
genesymbol_syn
TAPR1
resolver
hgnc
HGNC:30103
resolver
uniprot_entry
HAPR1_HUMAN
resolver
amino_acid_sequence
MEERKEEGEAEIQEHGPEHWFSKWERQCLAEAEQDEQLPPELQEEAAAAAQPEHKQQKLWHLFQNSATAVAQLYKDRVCQQPGLSLWVPFQNAATAVTNLYKESVDTHQRSFDIGIQIGYQRRNKDVLAWVKKRRRTIRREDLISFLCGKVPPPRNSRAPPRLTVVSPNRATSTETSSSVETDLQPFREAIALHGLSGAMASISVRSSTPGSPTHVSSGSNASRRRNGLHDVDLNTFISEEMALHLDNGGTRKRTSAQCGDVITDSPTHKRNRMI
uniprot
proteins
function
FUNCTION: Acts as a central player within a network of stress response pathways promoting cellular adaptability. The E3 ligase HUWE1 assists HAPSTR1 in controlling stress signaling and in turn, HUWE1 feeds back to promote the degradation of HAPSTR1. HAPSTR1 represents a central coordination mechanism for stress response programs (PubMed:35776542). Functions as a negative regulator of TP53/P53 in the cellular response to telomere erosion and probably also DNA damage (PubMed:33660365). May attenuate p53/TP53 activation through the E3 ubiquitin ligase HUWE1 (PubMed:33660365). {ECO:0000269|PubMed:33660365, ECO:0000269|PubMed:35776542}.
uniprot
proteins
mass_dalton
30926
uniprot
proteins
mutagenesis
MUTAGEN 90; /note="F->R: Loss of interaction with HUWE1. No effect on oligomerization. No effect on stabilization by HAPSTR2."; /evidence="ECO:0000269|PubMed:35776542, ECO:0000269|PubMed:36631436"; MUTAGEN 94; /note="A->R: Loss of interaction with HUWE1. No effect on oligomerization."; /evidence="ECO:0000269|PubMed:35776542"; MUTAGEN 101; /note="Y->A: Loss of interaction with HUWE1. No effect on oligomerization."; /evidence="ECO:0000269|PubMed:35776542"; MUTAGEN 119; /note="G->R: Decreased interaction with HUWE1. Loss of oligomerization. Increased proteasomal degradation. Loss of stabilization by HAPSTR2."; /evidence="ECO:0000269|PubMed:35776542
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by HUWE1. Promotes HAPSTR1 degradation through polyubiquitination. {ECO:0000269|PubMed:35776542}.
uniprot
proteins
protein_family
HAPSTR1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
33660365
uniprot
proteins
pubmed
35776542
uniprot
proteins
pubmed
36631436
uniprot
proteins
sequence_length
275
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:35776542}. Cytoplasm {ECO:0000269|PubMed:35776542}.
uniprot
proteins