Ank2
entrez
109676
canonical
uniprot
Q8C8R3
canonical
ensembl
ENSMUSG00000032826
resolver
ensp
ENSMUSP00000043765
resolver
ensp
ENSMUSP00000138620
resolver
ensp
ENSMUSP00000138753
resolver
enst
ENSMUST00000182078
resolver
genesymbol
Ank2
resolver
genesymbol_syn
AnkB
resolver
uniprot
Q3TM62
resolver
uniprot
Q3V2X0
resolver
uniprot
Q6PCN2
resolver
uniprot
Q80ZZ7
resolver
uniprot
Q8BNC1
resolver
uniprot
Q8C445
resolver
uniprot
Q8CCV0
resolver
uniprot
S4R2R5
resolver
uniprot_entry
ANK2_MOUSE
resolver
uniprot_entry
S4R2R5_MOUSE
resolver
uniprot_sec
Q3TM62
resolver
uniprot_sec
Q3V2X0
resolver
uniprot_sec
Q6PCN2
resolver
uniprot_sec
Q80ZZ7
resolver
uniprot_sec
Q8BNC1
resolver
uniprot_sec
Q8C445
resolver
uniprot_sec
Q8CCV0
resolver
amino_acid_sequence
MMNEDAAQKSDSGEKFNGSSQRRKRPKKSDSNASFLRAARAGNLDKVVEYLKGGIDINTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERKAPLLARTKNGLSPLHMAAQGDHVECVKHLLQYKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNTVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADRDAYTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTLKVVTEEVTTTTTTITEKHKLNVPETMTEVLDVSDEEGDDTVTGDGGEYLRPEDLKELGDDSLPSSQFLDGMNYLRYSLEGGRSDSLRSFSSDRSHTLSHASYLRDSAMIDDTVVIPSHQVSALAKEAERNSYRLSWGTENLDNVALSSSPIHSGFLVSFMVDARGGAMRGCRHNGLRIIIPPRKCTAPTRVTCRLVKRHRLATMPPMVEGEGLASRLIEVGPSGAQFLGPVIVEIPHFAALRGKERELVVLRSENGDSWKEHFCDYTEDELNEILNGMDEVLDSPEDLEKKRICRIITRDFPQYFAVVSRIKQDSNLIGPEGGVLSSTVVSQVQAVFPEGALTKRIRVGLQAQPMHSELVKKILGNKATFSPIVTLEPRRRKFHKPITMTIPVPKASSDVMLNGFGGDAPTLRLLCSITGGTTPAQWEDITGTTPLTFVNECVSFTTNVSARFWLIDCRQIQESVAFASQVYREIICVPYMAKFVVFAKSHDPIEARLRCFCMTDDKVDKTLEQQENFSEVARSRDVEVLEGKPIYVDCFGNLVPLTKSGQHHIFSFFAFKENRLPLFVKVRDTTQEPCGRLSFMKEPKSTRGLVHQAICNLNITLPIYAKESESDQEPEEEIGMTSEKNDETESTETSVLKSHLVNEVPVLASPDLLSEVSEMKQDLIKMTAILTTDVSDKAGSLKVKELAKAGEEEPGEPFEIVERVKEDLEKVNAILRSGTCMRDEGRARSSQSERELEEEWVIVSDEEIQEAKQHAPVEIDEHPCIEVRVDRETKAKVEKDSTGLVNYLTDDLNSYTSPHEKKPHTAPEKSGETSQASAVGKSSESNKGKATSAEEKQSAQKQLKPGLAIKKPVRRKLKEKQKQKEESSQSSEEKTELKKGSSEESVDEDRGLVPEPLPTAKATSPLIEETPIGSIKDKVKALQKRVEDEQKGRSKLPVRVKGKEDVPKRTTPRTHPAVSPSSKSSTSSKAERHSSLSSSAKPERHTPVSPSSKNEKLSPVSPSAKTERHSPVFSGKPEKHSPGSPSTKNERHSPVSSLKTERHTPGSPSGKTDKRPPVPSSGRTEKHPPVSPGKTEKHLPGSPSIRTPEKPAPGSATGKHEKHLPVSPGKTEKQPPISPTSKTERIEETMSVRELMKAFQSGQDPSKHKTGLFEHKSAKQKQPQDKSKSRVEKEKGHTVTQREVTQRETQRIESQTAKRGQRFQVSAATESRRFRSTTITVGLRMEDPVRERFERTPIIKTPEVVPSVAAEESHRGSEKIVDEQGDMDFQISPDRKTSTDFSEVIKQELEDNDKYQQFRLTEDTEKAQVHLDQVITSPFNTAFPLDYMKDEFLPALSLQSGALGGSSESLKQEVIAGSPCSSLMEGTPQISSEESYKHEGLAETPETSPESLSFSPKKSEEQIGEAKETTKVGTPTDIHSEKELPITNDITDSSQKQGAGVTRGSEPSTEHSQKEVTQDPHKDVCSKQDGCPESQSVSLASEVFTEKGSCGESQLPLVSSAFKTQSESETQESLTPSEVTKPFPPSDASVKTAEGTEPKPQGAIRSPQGLELPLPNRDSEVLSPMADESLAVSHKDSLEASPVLEDNSSHKTPDSLEPSPLKESPCRDSLESSPVEPKMKAGILPSHFPLPAAIAKTDLVAEVASMRSRLLRDPDGSAEDDSLEQTSLMESSGKSPLSPDTPSSEEVSYEVTPKPSDSSTPKPAVIHECAEEDDSENGEKKRFTPEEEMFKMVTKIKTFDELEQEAKQKRDYKKEPRQDGSSSASDPDADYSAEVNDEKQMAGTEGEGEVPVLVTSENRKVSSSSSESEPELTQLSKGADSGLLTEPVIRVQPPSPLPSSIDSNSSPEEATQFQPIVPKQYTFKMNEEIQEEPATSEDKDCKSHLAEDSQTHSADAADGSDGDLNRETTQPETCDGHGCETVSPSNSATPVSLGVQSPEHKDVDKPLAIDKDSLAHQDTCENDREEREFDPSGVESTQADLPNESSSLSSRCAIPEGNESAKEIASPSSPVKVEVTITDQALESMPEDCPIQDSSTTMQTERFAMDVPVSELAETDENSDPQIISPYENVPSSSFFSAEPSKIQTDTCHSTVVHSPEVYSVIIRSSPEDVVVTNSSNRTVSGEESHCESHDLETESEQKSALWAAQSDAPPLAVAPTASDAASVTGEQASKVIITKTDADADSWSEIREDDAAFEARVKEEEQKIFGLMVDRQSQGTTPDTTPARTPTEEGTPTSEQNPFLFQEGKLFEMTRSGAIDMTKRPYADESLHFFQIGQESNEEAISEDLKEGATGAEPPQTETTSESLELSEPKEAMDDEGELLPDDVSEEIEDLPASDANIDSQVIISASTETPTKEAVSTAVEEPPTTQRSDSLSTVKQTPRPAVPGPVGQLDFSPVTRSVYSGQDDESPESSPEEQKSVIEIPTAPVDNVPSAESKPQIPIRTLPTLVPAPPSAEDESAFSDDFPSSLDEDSKEGGAKPKSKIPVKAPTQRTEWQPSPTDIPLQKTAVPQGQETLSRAPDGRSKSESDASSLDAKTKCPVKARSYIETETESRERAEGFESESEDGATKPKLFASRLPVKSRSTSSSGRPGTSPTRESREHFFDLYRNSIEFFEEISDEASKLVDRLTQSEREQEPPSDDESSSALEVSVIESLPPVDIEHSAPEDIFDTRPIWDESIETMIERIPDENGHDRAEDPQDEQERMEERLAYIADHLGFSWTELARELDFTEEQIHQIRIENPNSLQDQSHALLKYWLERDGKHATDTILIECLTKINRMDIVHLLETNTEPLQERMGRSYAEIEQTITLDHSEGFSVLPDELCAAKEKKEQEASKESESSDHPPMVSEEDISVGYSTFQDCLPKTEGDSPAAALSPQMHQEPVQQDFSGKTQDQQEYYVTTPGAEVEDPQKATAVPDSLCKTPEDISTPPEGTKPCLQTPVTSERGSPIVQEPEEASEPKEESSPRKTSLVIVESTDDQSQVFERLDGDAAFQKGDDMPDIPPETVTEEEYVDENGHTVVKKVTRKIIRRYVSSDGTEKEEVTMQGMPQEPVNIEDGDNYSKVIKRVVLKSDTQQSEDNNE
uniprot
proteins
function
FUNCTION: Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions (PubMed:19109891). In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites (PubMed:12571597). Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:15262991). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (PubMed:19007774). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (PubMed:27718357). {ECO:0000269|PubMed:12571597, ECO:0000269|PubMed:15262991, ECO:0000269|PubMed:19007774, ECO:0000269|PubMed:19109891, ECO:0000269|PubMed:27718357}.
uniprot
proteins
mass_dalton
426261
uniprot
proteins
mutagenesis
MUTAGEN 1194; /note="R->A: Loss of binding to phosphatidylinositol 3-phosphate (PI3P) lipids and loss of localization to PI3P-positive organelles. Expression of mutant protein does not rescue ITGB1 recycling deficit of ANK2 null mutant fibroblasts."; /evidence="ECO:0000269|PubMed:27718357"; MUTAGEN 1318..1319; /note="DD->AA: Loss of long-range transport of PI3P-positive organelles in embryonic fibroblasts. Expression of mutant protein in ANK2 null mutant fibroblasts partially rescues ITGB1 recycling to about 50% of the wild-type levels."; /evidence="ECO:0000269|PubMed:27718357"; MUTAGEN 3575; /note="E->A: Significantly weaker interaction with RABGAP1L."; /evidence="ECO:0000269|PubMed:27718357"; MUTAGEN 3575; /note="E->K: Loss of interaction with RABGAP1L. Localizes on motile vesicles, but does not cotransport with RABGAP1L. Loss of polarized transport of PI3P-positive organelles to the leading edge of the migrating fibroblasts. Expression of mutant protein does not rescue ITGB1 recycling deficit of ANK2 null mutant fibroblasts nor the impaired haptotactic response of the fibroblasts."; /evidence="ECO:0000269|PubMed:27718357
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at multiple sites by different protein kinases and each phosphorylation event regulates the protein's structure and function. {ECO:0000250|UniProtKB:Q01484, ECO:0000305}.
uniprot
proteins
pubmed
12571597
uniprot
proteins
pubmed
15262991
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17940615
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19007774
uniprot
proteins
pubmed
19109891
uniprot
proteins
pubmed
19299621
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21745462
uniprot
proteins
pubmed
27718357
uniprot
proteins
pubmed
8253844
uniprot
proteins
sequence_length
3898
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q01484}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000269|PubMed:12571597, ECO:0000269|PubMed:19109891}. Cell membrane {ECO:0000269|PubMed:19007774}. Photoreceptor inner segment membrane {ECO:0000269|PubMed:19007774, ECO:0000269|PubMed:19299621}. Postsynaptic cell membrane {ECO:0000269|PubMed:19109891}. Early endosome {ECO:0000269|PubMed:27718357}. Recycling endosome {ECO:0000269|PubMed:27718357}. Lysosome {ECO:0000269|PubMed:27718357}. Mitochondrion {ECO:0000269|PubMed:27718357}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:12571597}. Cell membrane, sarcolemma, T-tubule {ECO:0000269|PubMed:12571597}. Note=Expressed at the apical membrane of airway lung epithelial cells. Localized to the plasma membrane of the inner segments of photoreceptors in retina (PubMed:19007774). Colocalizes with SPTBN1 in a distinct intracellular compartment of neonatal cardiomyocytes (PubMed:15262991). In skeletal muscle, localizes to neuromuscular junctions (PubMed:19109891). Localizes with puncta at mitochondria ends. Colocalizes and cotransports on motile vesicles with RABGAP1L (PubMed:27718357). {ECO:0000269|PubMed:15262991, ECO:0000269|PubMed:19007774, ECO:0000269|PubMed:19109891, ECO:0000269|PubMed:27718357}.
uniprot
proteins