SLC9A5
entrez
6553
canonical
uniprot
Q14940
canonical
ensembl
ENSG00000135740
resolver
ensp
ENSP00000299798
resolver
ensp
ENSP00000567551
resolver
ensp
ENSP00000598335
resolver
ensp
ENSP00000722813
resolver
enst
ENST00000299798
resolver
genesymbol
SLC9A5
resolver
genesymbol_syn
NHE5
resolver
hgnc
HGNC:11078
resolver
uniprot
A5PKY7
resolver
uniprot
Q9Y626
resolver
uniprot_entry
SL9A5_HUMAN
resolver
uniprot_sec
A5PKY7
resolver
uniprot_sec
Q9Y626
resolver
activity_regulation
ACTIVITY REGULATION: ATP-depletion almost completely abolishes SLC9A5 activity. Inhibited by amiloride compounds. {ECO:0000269|PubMed:10692428}.
uniprot
proteins
amino_acid_sequence
MLRAALSLLALPLAGAAEEPTQKPESPGEPPPGLELFRWQWHEVEAPYLVALWILVASLAKIVFHLSRKVTSLVPESCLLILLGLVLGGIVLAVAKKAEYQLEPGTFFLFLLPPIVLDSGYFMPSRLFFDNLGAILTYAVVGTLWNAFTTGAALWGLQQAGLVAPRVQAGLLDFLLFGSLISAVDPVAVLAVFEEVHVNETLFIIVFGESLLNDAVTVVLYKVCNSFVEMGSANVQATDYLKGVASLFVVSLGGAAVGLVFAFLLALTTRFTKRVRIIEPLLVFLLAYAAYLTAEMASLSAILAVTMCGLGCKKYVEANISHKSRTTVKYTMKTLASCAETVIFMLLGISAVDSSKWAWDSGLVLGTLIFILFFRALGVVLQTWVLNQFRLVPLDKIDQVVMSYGGLRGAVAFALVILLDRTKVPAKDYFVATTIVVVFFTVIVQGLTIKPLVKWLKVKRSEHHKPTLNQELHEHTFDHILAAVEDVVGHHGYHYWRDRWEQFDKKYLSQLLMRRSAYRIRDQIWDVYYRLNIRDAISFVDQGGHVLSSTGLTLPSMPSRNSVAETSVTNLLRESGSGACLDLQVIDTVRSGRDREDAVMHHLLCGGLYKPRRRYKASCSRHFISEDAQERQDKEVFQQNMKRRLESFKSTKHNICFTKSKPRPRKTGRRKKDGVANAEATNGKHRGLGFQDTAAVILTVESEEEEEESDSSETEKEDDEGIIFVARATSEVLQEGKVSGSLEVCPSPRIIPPSPTCAEKELPWKSGQGDLAVYVSSETTKIVPVDMQTGWNQSISSLESLASPPCNQAPILTCLPPHPRGTEEPQVPLHLPSDPRSSFAFPPSLAKAGRSRSESSADLPQQQELQPLMGHKDHTHLSPGTATSHWCIQFNRGSRL
uniprot
proteins
function
FUNCTION: Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, thus regulating intracellular pH homeostasis, in particular in neural tissues (PubMed:10692428, PubMed:19276089, PubMed:24936055, PubMed:9933641). Acts as a negative regulator of dendritic spine growth (PubMed:21551074). Plays a role in postsynaptic remodeling and signaling (PubMed:21551074, PubMed:24006492). Can also contribute to organellar pH regulation, with consequences for receptor tyrosine kinase trafficking (PubMed:24936055). {ECO:0000269|PubMed:10692428, ECO:0000269|PubMed:19276089, ECO:0000269|PubMed:21551074, ECO:0000269|PubMed:24006492, ECO:0000269|PubMed:24936055, ECO:0000269|PubMed:9933641}.
uniprot
proteins
mass_dalton
99011
uniprot
proteins
mutagenesis
MUTAGEN 697..698; /note="IL->AA: Does not disrupt the binding of ARRB2. Impaired endocytosis of SLC9A5."; /evidence="ECO:0000269|PubMed:21296876"; MUTAGEN 702; /note="S->A: Abolishes SLC9A5 phosphorylation by CSNK2A1 and abolishes CSNK2A1-mediated binding of ARRB2; when associated with A-709; A-711; A-712 and A-714."; /evidence="ECO:0000269|PubMed:21296876"; MUTAGEN 702; /note="S->D: Abolishes SLC9A5 phosphorylation by CSNK2A1 and abolishes CSNK2A1-mediated binding of ARRB2; when associated with D-709; D-711; D-712 and D-714."; /evidence="ECO:0000269|PubMed:21296876"; MUTAGEN 709; /note="S->A: Abolishes SLC9A5 phosphorylation by CSNK2A1 and abolishes CSNK2A1-mediated binding of ARRB2; when associated with A-702; A-711; A-712 and A-714."; /evidence="ECO:0000269|PubMed:21296876"; MUTAGEN 709; /note="S->D: Abolishes SLC9A5 phosphorylation by CSNK2A1 and abolishes CSNK2A1-mediated binding of ARRB2; when associated with D-702; D-711; D-712 and D-714."; /evidence="ECO:0000269|PubMed:21296876"; MUTAGEN 711; /note="S->A: Abolishes SLC9A5 phosphorylation by CSNK2A1 and abolishes CSNK2A1-mediated binding of ARRB2; when associated with A-702; A-709; A-712 and A-714."; /evidence="ECO:0000269|PubMed:21296876"; MUTAGEN 711; /note="S->D: Abolishes SLC9A5 phosphorylation by CSNK2A1 and abolishes CSNK2A1-mediated binding of ARRB2; when associated with D-702; D-709; D-712 and D-714."; /evidence="ECO:0000269|PubMed:21296876"; MUTAGEN 712; /note="S->A: Abolishes SLC9A5 phosphorylation by CSNK2A1 and abolishes CSNK2A1-mediated binding of ARRB2; when associated with A-702; A-709; A-711 and A-714."; /evidence="ECO:0000269|PubMed:21296876"; MUTAGEN 712; /note="S->D: Abolishes SLC9A5 phosphorylation by CSNK2A1 and abolishes CSNK2A1-mediated binding of ARRB2; when associated with D-702; D-709; D-711 and D-714."; /evidence="ECO:0000269|PubMed:21296876"; MUTAGEN 714; /note="T->A: Abolishes SLC9A5 phosphorylation by CSNK2A1 and abolishes CSNK2A1-mediated binding of ARRB2; when associated with A-702; A-709; A-711 and A-712."; /evidence="ECO:0000269|PubMed:21296876"; MUTAGEN 714; /note="T->D: Abolishes SLC9A5 phosphorylation by CSNK2A1 and abolishes CSNK2A1-mediated binding of ARRB2; when associated with D-702; D-709; D-711 and D-712."; /evidence="ECO:0000269|PubMed:21296876"; MUTAGEN 722..723; /note="II->AA: Does not disrupt the binding of ARRB2. Does not affect endocytosis of SLC9A5."; /evidence="ECO:0000269|PubMed:21296876
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PRKAA2; promotes its accumulation at the cell surface (PubMed:24936055). Phosphorylated by CSNK2A1 in a manner favoring its beta-arrestin binding and endocytosis (PubMed:21296876). {ECO:0000269|PubMed:21296876, ECO:0000269|PubMed:24936055}.
uniprot
proteins
protein_family
Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
uniprot
proteins
pubmed
10692428
uniprot
proteins
pubmed
12205089
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15699339
uniprot
proteins
pubmed
19276089
uniprot
proteins
pubmed
21296876
uniprot
proteins
pubmed
21551074
uniprot
proteins
pubmed
24006492
uniprot
proteins
pubmed
24936055
uniprot
proteins
pubmed
7759094
uniprot
proteins
pubmed
9933641
uniprot
proteins
sequence_length
896
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12205089, ECO:0000269|PubMed:15699339, ECO:0000269|PubMed:19276089, ECO:0000269|PubMed:21296876, ECO:0000269|PubMed:21551074, ECO:0000269|PubMed:24936055}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000269|PubMed:12205089, ECO:0000269|PubMed:21296876}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendritic spine membrane {ECO:0000269|PubMed:21551074}; Multi-pass membrane protein {ECO:0000255}. Synaptic cell membrane {ECO:0000269|PubMed:21551074}; Multi-pass membrane protein. Cell junction, focal adhesion {ECO:0000269|PubMed:24006492}. Note=Cycles between recycling endosome and plasma membrane in response to diverse stimuli. Its internalization is clathrin- and beta-arrestin dependent and its plasma membrane insertion from the recycling endosomes requires phosphoinositide 3-kinase (PIK3CA) and SCAMP2. {ECO:0000269|PubMed:12205089, ECO:0000269|PubMed:15699339, ECO:0000269|PubMed:19276089, ECO:0000269|PubMed:21296876}.
uniprot
proteins
transmembrane_region
TRANSMEM 46..66; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 74..94; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 104..124; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 135..155; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 174..194; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 201..221; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 247..267; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 277..297; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 332..352; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 361..381; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 399..419; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 429..449; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins