Sox6
entrez
20679
canonical
uniprot
P40645
canonical
ensembl
ENSMUSG00000051910
resolver
ensp
ENSMUSP00000072583
resolver
ensp
ENSMUSP00000102223
resolver
ensp
ENSMUSP00000126404
resolver
ensp
ENSMUSP00000129027
resolver
ensp
ENSMUSP00000129512
resolver
ensp
ENSMUSP00000145732
resolver
ensp
ENSMUSP00000145919
resolver
ensp
ENSMUSP00000145931
resolver
ensp
ENSMUSP00000279685
resolver
ensp
ENSMUSP00000279686
resolver
ensp
ENSMUSP00000279687
resolver
ensp
ENSMUSP00000279688
resolver
ensp
ENSMUSP00000279690
resolver
ensp
ENSMUSP00000279693
resolver
ensp
ENSMUSP00000279696
resolver
ensp
ENSMUSP00000279699
resolver
ensp
ENSMUSP00000279700
resolver
ensp
ENSMUSP00000279703
resolver
enst
ENSMUST00000106612
resolver
enst
ENSMUST00000166877
resolver
enst
ENSMUST00000169129
resolver
enst
ENSMUST00000205405
resolver
enst
ENSMUST00000206034
resolver
enst
ENSMUST00000206369
resolver
genesymbol
Sox6
resolver
genesymbol_syn
Sox-6
resolver
uniprot
A0A0U1RNW8
resolver
uniprot
A0A0U1RPC1
resolver
uniprot
E9PUW0
resolver
uniprot
F6ZJ99
resolver
uniprot
Q3V1J7
resolver
uniprot
Q62250
resolver
uniprot
Q8BSS6
resolver
uniprot
Q9QWS5
resolver
uniprot_entry
A0A0U1RNW8_MOUSE
resolver
uniprot_entry
A0A0U1RPC1_MOUSE
resolver
uniprot_entry
E9PUW0_MOUSE
resolver
uniprot_entry
F6ZJ99_MOUSE
resolver
uniprot_entry
Q3V1J7_MOUSE
resolver
uniprot_entry
Q8BSS6_MOUSE
resolver
uniprot_entry
SOX6_MOUSE
resolver
uniprot_sec
Q62250
resolver
uniprot_sec
Q9QWS5
resolver
amino_acid_sequence
MSSKQATSPFACTADGEEAMTQDLTSREKEEGSDQHPASHLPLHPIMHNKPHSEELPTLVSTIQQDADWDSVLSSQQRMESENNKLCSLYSFRNTSTSPHKPDEGSREREIMNSVTFGTPERRKGSLADVVDTLKQKKLEEMTRTEQEDSSCMEKLLSKDWKEKMERLNTSELLGEIKGTPESLAEKERQLSTMITQLISLREQLLAAHDEQKKLAASQIEKQRQQMDLARQQQEQIARQQQQLLQQQHKINLLQQQIQVQGHMPPLMIPIFPHDQRTLAAAAAAQQGFLFPPGITYKPGDNYPVQFIPSTMAAAAASGLSPLQLQKGHVSHPQINPRLKGISDRFGRNLDPSEHGGGHSYNHRQIEQLYAAQLASMQVSPGAKMPSTPQPPNSAGAVSPTGIKNEKRGTSPVTQVKDETTAQPLNLSSRPKTAEPVKSPTSPTQNLFPASKTSPVNLPNKSSIPSPIGGSLGRGSSLDILSSLNSPALFGDQDTVMKAIQEARKMREQIQREQQQQPHGVDGKLSSMNNMGLSNCRTEKERTRFENLGPQLTGKSSEDGKLGPGVIDLTRPEDAEGSKAMNGSAAKLQQYYCWPTGGATVAEARVYRDARGRASSEPHIKRPMNAFMVWAKDERRKILQAFPDMHNSNISKILGSRWKSMSNQEKQPYYEEQARLSKIHLEKYPNYKYKPRPKRTCIVDGKKLRIGEYKQLMRSRRQEMRQFFTVGQQPQMPITTGTGVVYPGAITMATTTPSPQMTSDCSSTSASPEPSLPVIQSTYGMKMDGASLAGNDMINGEDEMEAYDDYEDDPKSDYSSENEAPEPVSAN
uniprot
proteins
function
FUNCTION: Transcription factor that plays a key role in several developmental processes, including neurogenesis, chondrocytes differentiation and cartilage formation (Probable). Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis (PubMed:11702786, PubMed:9755172). Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate (PubMed:11702786, PubMed:15529345, PubMed:26150426). Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes (PubMed:14993235, PubMed:26150426). Together with SOX5, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts (PubMed:14993235). Binds to the proximal promoter region of the myelin protein MPZ gene, and is thereby involved in the differentiation of oligodendroglia in the developing spinal tube (PubMed:26525805). Binds to the gene promoter of MBP and acts as a transcriptional repressor (PubMed:26525805). {ECO:0000269|PubMed:11702786, ECO:0000269|PubMed:14993235, ECO:0000269|PubMed:15529345, ECO:0000269|PubMed:26150426, ECO:0000269|PubMed:26525805, ECO:0000269|PubMed:32442410, ECO:0000269|PubMed:7567444, ECO:0000269|PubMed:9755172, ECO:0000305|PubMed:32442410}.
uniprot
proteins
mass_dalton
91803
uniprot
proteins
mutagenesis
MUTAGEN 161; /note="W->C: Decreased localization to the nucleus. No effect on homodimerization. No effect on transcription cis-regulatory region binding. No effect on DNA-binding transcription factor activity."; /evidence="ECO:0000269|PubMed:32442410"; MUTAGEN 624; /note="M->T: Decreased localization to the nucleus. No effect on homodimerization. Decreased transcription cis-regulatory region binding. Loss of DNA-binding transcription factor activity. Acts as a dominant negative."; /evidence="ECO:0000269|PubMed:32442410"; MUTAGEN 658; /note="W->R: Loss of localization to the nucleus. Loss of transcription cis-regulatory region binding. Loss of DNA-binding transcription factor activity. Acts as a dominant negative."; /evidence="ECO:0000269|PubMed:32442410"; MUTAGEN 765; /note="S->L: Increased localization to the nucleus. Decreased transcription cis-regulatory region binding. No effect on DNA-binding transcription factor activity."; /evidence="ECO:0000269|PubMed:32442410
uniprot
proteins
post_translational_modification
PTM: Sumoylation inhibits the transcriptional activity. {ECO:0000250|UniProtKB:P35712}.
uniprot
proteins
pubmed
10996314
uniprot
proteins
pubmed
11702786
uniprot
proteins
pubmed
12414734
uniprot
proteins
pubmed
14530442
uniprot
proteins
pubmed
14993235
uniprot
proteins
pubmed
15529345
uniprot
proteins
pubmed
1614875
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26150426
uniprot
proteins
pubmed
26525805
uniprot
proteins
pubmed
27923061
uniprot
proteins
pubmed
32442410
uniprot
proteins
pubmed
7567444
uniprot
proteins
pubmed
7791783
uniprot
proteins
pubmed
9755172
uniprot
proteins
sequence_length
827
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:32442410}. Cytoplasm {ECO:0000269|PubMed:32442410}.
uniprot
proteins