CCL20
entrez
6364
canonical
uniprot
P78556
canonical
ensembl
ENSG00000115009
resolver
ensp
ENSP00000351671
resolver
ensp
ENSP00000386273
resolver
genesymbol
CCL20
resolver
genesymbol_syn
LARC
resolver
genesymbol_syn
MIP3A
resolver
genesymbol_syn
SCYA20
resolver
hgnc
HGNC:10619
resolver
uniprot
Q53S51
resolver
uniprot
Q99664
resolver
uniprot_entry
CCL20_HUMAN
resolver
uniprot_sec
Q53S51
resolver
uniprot_sec
Q99664
resolver
amino_acid_sequence
MCCTKSLLLAALMSVLLLHLCGESEAASNFDCCLGYTDRILHPKFIVGFTRQLANEGCDINAIIFHTKKKLSVCANPKQTWVKYIVRLLSKKVKNM
uniprot
proteins
function
FUNCTION: Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:11035086, PubMed:11352563, PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases (PubMed:21376174). CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes (PubMed:11352563, PubMed:9038201). Involved in the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells (By similarity). C-terminal processed forms have been shown to be equally chemotactically active for leukocytes (PubMed:11035086). Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:23765988, PubMed:25122636). Inhibits proliferation of myeloid progenitors in colony formation assays (PubMed:9129037). May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells (By similarity). Possesses antibacterial activity towards E.coli ATCC 25922 and S.aureus ATCC 29213 (PubMed:12149255). {ECO:0000250|UniProtKB:O89093, ECO:0000269|PubMed:11035086, ECO:0000269|PubMed:11352563, ECO:0000269|PubMed:12149255, ECO:0000269|PubMed:20068036, ECO:0000269|PubMed:23765988, ECO:0000269|PubMed:25122636, ECO:0000269|PubMed:9038201, ECO:0000269|PubMed:9129037, ECO:0000303|PubMed:21376174}.
uniprot
proteins
mass_dalton
10762
uniprot
proteins
post_translational_modification
PTM: C-terminal processed forms which lack 1, 3 or 6 amino acids are produced by proteolytic cleavage after secretion from peripheral blood monocytes. {ECO:0000269|PubMed:11035086}.
uniprot
proteins
protein_family
Intercrine beta (chemokine CC) family
uniprot
proteins
pubmed
11035086
uniprot
proteins
pubmed
11352563
uniprot
proteins
pubmed
12149255
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
20068036
uniprot
proteins
pubmed
21376174
uniprot
proteins
pubmed
23765988
uniprot
proteins
pubmed
25122636
uniprot
proteins
pubmed
9013939
uniprot
proteins
pubmed
9038201
uniprot
proteins
pubmed
9129037
uniprot
proteins
sequence_length
96
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11035086}.
uniprot
proteins