Igf2
entrez
24483
canonical
uniprot
P01346
canonical
ensembl
ENSRNOG00000020369
resolver
ensp
ENSRNOP00000099605
resolver
enst
ENSRNOT00000164793
resolver
genesymbol
Igf2
resolver
genesymbol_syn
Igf-2
resolver
uniprot
A0ABK0L5X2
resolver
uniprot
M9NW49
resolver
uniprot_entry
A0ABK0L5X2_RAT
resolver
uniprot_entry
IGF2_RAT
resolver
uniprot_entry
M9NW49_RAT
resolver
amino_acid_sequence
MGIPVGKSMLVLLISLAFALCCIAAYRPSETLCGGELVDTLQFVCSDRGFYFSRPSSRANRRSRGIVEECCFRSCDLALLETYCATPAKSERDVSTSQAVLPDDFPRYPVGKFFKFDTWRQSAGRLRRGLPALLRARRGRMLAKELEAFREAKRHRPLIVLPPKDPAHGGASSEMSSNHQ
uniprot
proteins
function
FUNCTION: The insulin-like growth factors possess growth-promoting activity (By similarity). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF2 is influenced by placental lactogen. Also involved in tissue differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is required for IGF2 signaling. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (By similarity). {ECO:0000250|UniProtKB:P01344, ECO:0000250|UniProtKB:P09535}.; FUNCTION: Preptin undergoes glucose-mediated co-secretion with insulin, and acts as a physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3. {ECO:0000250|UniProtKB:P01344, ECO:0000250|UniProtKB:P09535}.
uniprot
proteins
mass_dalton
20086
uniprot
proteins
post_translational_modification
PTM: Proteolytically processed by PCSK4, proIGF2 is cleaved at Arg-128 and Arg-92 to generate big-IGF2 and mature IGF2. {ECO:0000250|UniProtKB:P01344}.
uniprot
proteins
protein_family
Insulin family
uniprot
proteins
pubmed
16912056
uniprot
proteins
pubmed
2438416
uniprot
proteins
pubmed
3023383
uniprot
proteins
pubmed
3167060
uniprot
proteins
pubmed
3221878
uniprot
proteins
pubmed
3889836
uniprot
proteins
pubmed
6382022
uniprot
proteins
pubmed
6390212
uniprot
proteins
pubmed
7016879
uniprot
proteins
sequence_length
180
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01344, ECO:0000250|UniProtKB:P09535}.
uniprot
proteins