COX19
entrez
90639
canonical
uniprot
Q49B96
canonical
ensembl
ENSG00000240230
resolver
ensp
ENSP00000342015
resolver
enst
ENST00000344111
resolver
genesymbol
COX19
resolver
hgnc
HGNC:28074
resolver
uniprot
A4FTX0
resolver
uniprot_entry
COX19_HUMAN
resolver
uniprot_sec
A4FTX0
resolver
amino_acid_sequence
MSTAMNFGTKSFQPRPPDKGSFPLDHLGECKSFKEKFMKCLHNNNFENALCRKESKEYLECRMERKLMLQEPLEKLGFGDLTSGKSEAKK
uniprot
proteins
function
FUNCTION: Assembly factor for cytochrome c oxidase (respiratory chain complex IV, CIV) (PubMed:35750769). Acts as a COX11 chaperone that supports COX11 copper coordination (PubMed:35750769). Also stimulates SCO2-mediated metalation of COX2 (PubMed:35750769). Required for the transduction of an SCO1-dependent redox signal from the mitochondrion to ATP7A to regulate cellular copper homeostasis (PubMed:23345593). In the absence of COX11, capable of stimulating copper delivery to the copper B site of COX1 (PubMed:35750769). {ECO:0000269|PubMed:23345593, ECO:0000269|PubMed:35750769}.
uniprot
proteins
mass_dalton
10394
uniprot
proteins
protein_family
COX19 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16212937
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23345593
uniprot
proteins
pubmed
23676665
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
35750769
uniprot
proteins
sequence_length
90
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:16212937, ECO:0000269|PubMed:23345593, ECO:0000269|PubMed:23676665}. Mitochondrion intermembrane space {ECO:0000269|PubMed:23345593, ECO:0000269|PubMed:23676665, ECO:0000305|PubMed:35750769}. Mitochondrion {ECO:0000269|PubMed:23345593, ECO:0000269|PubMed:23676665}. Note=Partitions between mitochondria and the cytosol in a copper-dependent manner. Enriched in the cytosol when intracellular copper concentrations are elevated. {ECO:0000269|PubMed:23345593}.
uniprot
proteins