Tmem41b
entrez
361626
canonical
uniprot
Q5FVN2
canonical
ensembl
ENSRNOG00000010752
resolver
ensembl
ENSRNOG00055025320
resolver
ensembl
ENSRNOG00060019687
resolver
ensembl
ENSRNOG00065029276
resolver
ensp
ENSRNOP00000016224
resolver
ensp
ENSRNOP00055035642
resolver
ensp
ENSRNOP00060027861
resolver
ensp
ENSRNOP00065041573
resolver
enst
ENSRNOT00000016224
resolver
enst
ENSRNOT00055043652
resolver
enst
ENSRNOT00060034019
resolver
enst
ENSRNOT00065050596
resolver
genesymbol
Tmem41b
resolver
uniprot_entry
TM41B_RAT
resolver
amino_acid_sequence
MAKGRVAERSQTEMLHSTPAGDRAVGTQGSAAPGNKDHLKEKPCVEAGSARTSLLILVSIFSCAAFVMFLVYKNFPQLSEEERVNMKVPRDMDDAKALGKVLSKYKDTFYVQVLVAYFATYIFLQTFAIPGSIFLSILSGFLYPFPLALFLVCLCSGLGASFCYMLSYLVGRPVVYKYLTEKAVKWSQQVERHREHLINYIIFLRITPFLPNWFINITSPVINVPLKVFFIGTFLGVAPPSFVAIKAGTTLYQLTTAGEAVSWNSVFILMILALLSILPAIFQKKLKQKFE
uniprot
proteins
function
FUNCTION: Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes. Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine. Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly. In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required (By similarity). Required for normal motor neuron development (By similarity). {ECO:0000250|UniProtKB:A1A5V7, ECO:0000250|UniProtKB:Q5BJD5}.
uniprot
proteins
mass_dalton
32511
uniprot
proteins
protein_family
TMEM41 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
291
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q5BJD5}; Multi-pass membrane protein {ECO:0000255}. Endomembrane system {ECO:0000250|UniProtKB:Q5BJD5}. Note=Localized to specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. {ECO:0000250|UniProtKB:Q5BJD5}.
uniprot
proteins
transmembrane_region
TRANSMEM 52..72; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 109..129; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 147..169; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 197..217; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 225..245; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 262..282; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins