Mmgt1
entrez
302864
canonical
uniprot
B5DF51
canonical
ensembl
ENSRNOG00000065883
resolver
ensembl
ENSRNOG00055027633
resolver
ensembl
ENSRNOG00060022748
resolver
ensembl
ENSRNOG00065028389
resolver
ensp
ENSRNOP00000093526
resolver
ensp
ENSRNOP00055039427
resolver
ensp
ENSRNOP00060032702
resolver
ensp
ENSRNOP00065040092
resolver
enst
ENSRNOT00000108706
resolver
enst
ENSRNOT00055047887
resolver
enst
ENSRNOT00060039516
resolver
enst
ENSRNOT00065048902
resolver
genesymbol
Mmgt1
resolver
genesymbol_syn
Emc5
resolver
genesymbol_syn
Tmem32
resolver
uniprot_entry
EMC5_RAT
resolver
amino_acid_sequence
MAPSLWKGLVGVGLFALAHAAFSAAQHRSYMRLTEKEDESLPIDIVLQTLLAFAVTCYGIVHIAGEFKDMDATSELKNKTFDTLRNHPSFYVFNHRGRVLFRPSDATNSSNLDALSSNTSLKLRKFDSLRR
uniprot
proteins
function
FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (By similarity). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. May be involved in Mg(2+) transport (By similarity). {ECO:0000250|UniProtKB:Q8K273, ECO:0000250|UniProtKB:Q8N4V1}.
uniprot
proteins
mass_dalton
14677
uniprot
proteins
protein_family
Membrane magnesium transporter (TC 1.A.67) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
131
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8N4V1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8N4V1}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8K273}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8N4V1}. Early endosome membrane {ECO:0000250|UniProtKB:Q8K273}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8N4V1}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..22; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q8N4V1"; TRANSMEM 44..63; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q8N4V1
uniprot
proteins