IL37
entrez
27178
canonical
uniprot
Q9NZH6
canonical
ensembl
ENSG00000125571
resolver
ensp
ENSP00000263326
resolver
ensp
ENSP00000263327
resolver
ensp
ENSP00000263328
resolver
ensp
ENSP00000309208
resolver
ensp
ENSP00000309883
resolver
genesymbol
IL37
resolver
genesymbol_syn
FIL1Z
resolver
genesymbol_syn
IL1F7
resolver
genesymbol_syn
IL1H4
resolver
genesymbol_syn
IL1RP1
resolver
hgnc
HGNC:15563
resolver
uniprot
B5BU97
resolver
uniprot
Q56AP9
resolver
uniprot
Q8TD04
resolver
uniprot
Q8TD05
resolver
uniprot
Q9HBF2
resolver
uniprot
Q9HBF3
resolver
uniprot
Q9UHA6
resolver
uniprot_entry
IL37_HUMAN
resolver
uniprot_sec
B5BU97
resolver
uniprot_sec
Q56AP9
resolver
uniprot_sec
Q8TD04
resolver
uniprot_sec
Q8TD05
resolver
uniprot_sec
Q9HBF2
resolver
uniprot_sec
Q9HBF3
resolver
uniprot_sec
Q9UHA6
resolver
amino_acid_sequence
MSFVGENSGVKMGSEDWEKDEPQCCLEDPAGSPLEPGPSLPTMNFVHTSPKVKNLNPKKFSIHDQDHKVLVLDSGNLIAVPDKNYIRPEIFFALASSLSSASAEKGSPILLGVSKGEFCLYCDKDKGQSHPSLQLKKEKLMKLAAQKESARRPFIFYRAQVGSWNMLESAAHPGWFICTSCNCNEPVGVTDKFENRKHIEFSFQPVCKAEMSPSEVSD
uniprot
proteins
disease_involvement
DISEASE: Inflammatory bowel disease 31, autosomal recessive (IBD31) [MIM:619398]: A form of inflammatory bowel disease, a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology and a multifactorial inheritance pattern. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. IBD31 patients suffer from infantile ulcerative colitis and present with recurrent bloody diarrhea with anemia and leukocytosis, extensive lymphoplasmocytic infiltration, cryptitis, and apoptotic crypt abcesses throughout the colon and rectum. {ECO:0000269|PubMed:33674380}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Immune regulatory cytokine that acts as a suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. Signaling can occur via two mechanisms, intracellularly through nuclear translocation with SMAD3 and extracellularly after secretion and binding to its receptor composed of IL18R1 and IL18RAP. Suppresses, or reduces, pro-inflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation. {ECO:0000269|PubMed:18390730, ECO:0000269|PubMed:20935647, ECO:0000269|PubMed:33674380}.
uniprot
proteins
mass_dalton
24126
uniprot
proteins
post_translational_modification
PTM: Proteolytically converted to the mature form by CASP1.
uniprot
proteins
protein_family
IL-1 family
uniprot
proteins
pubmed
10625660
uniprot
proteins
pubmed
10744718
uniprot
proteins
pubmed
11145836
uniprot
proteins
pubmed
11991723
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18390730
uniprot
proteins
pubmed
19054851
uniprot
proteins
pubmed
20935647
uniprot
proteins
pubmed
32272059
uniprot
proteins
pubmed
33674380
uniprot
proteins
sequence_length
218
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18390730, ECO:0000269|PubMed:20935647}. Nucleus {ECO:0000269|PubMed:18390730, ECO:0000269|PubMed:20935647, ECO:0000269|PubMed:33674380}. Secreted {ECO:0000269|PubMed:11145836, ECO:0000269|PubMed:18390730, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:33674380}. Note=Stimulation with IL1B leads to colocalization with SMAD3 mostly in perinuclear regions (PubMed:20935647, PubMed:33674380). Only the CASP1-cleaved mature form translocates into the nucleus upon LPS stimulation (PubMed:18390730). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059, PubMed:33674380). {ECO:0000269|PubMed:18390730, ECO:0000269|PubMed:20935647, ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:33674380}.
uniprot
proteins