TOP2B
entrez
7155
canonical
uniprot
Q02880
canonical
ensembl
ENSG00000077097
resolver
ensp
ENSP00000264331
resolver
ensp
ENSP00000396704
resolver
ensp
ENSP00000627417
resolver
ensp
ENSP00000705390
resolver
genesymbol
TOP2B
resolver
hgnc
HGNC:11990
resolver
uniprot
Q13600
resolver
uniprot
Q59H80
resolver
uniprot
Q9UMG8
resolver
uniprot
Q9UQP8
resolver
uniprot_entry
Q59H80_HUMAN
resolver
uniprot_entry
TOP2B_HUMAN
resolver
uniprot_sec
Q13600
resolver
uniprot_sec
Q9UMG8
resolver
uniprot_sec
Q9UQP8
resolver
amino_acid_sequence
MAKSGGCGAGAGVGGGNGALTWVTLFDQNNAAKKEESETANKNDSSKKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDVGMNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKHSFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAGSCRGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGFQQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKNKAGVSVKPFQVKNHIWVFINCLIENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKCSSVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAWKIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNFMEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIGQFGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMVLINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGTIQELGQNQYAVSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKFVVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLSYYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVKAWKEAQEKAAEEDETQNQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQRDAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVESQEREDVLAGMSGKAIKGKVGKPKVKKLQLEETMPSPYGRRIIPEITAMKADASKKLLKKKKGDLDTAAVKVEFDEEFSGAPVEGAGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPSAKKVKKRNPWSDDESKSESDLEETEPVVIPRDSLLRRAAAERPKYTFDFSEEEDDDADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKFDSNEEDSASVFSPSFGLKQTDKVPSKTVAAKKGKPSSDTVPKPKRAPKQKKVVEAVNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNPGRKTSKTTSKKPKKTSFDQDSDVDIFPSDFPTEPPSLPRTGRARKEVKYFAESDEEEDDVDFAMFN
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in TOP2B may be involved in global developmental delay with autism spectrum disorder (ASD). {ECO:0000269|PubMed:28343847, ECO:0000269|PubMed:31953910}.; DISEASE: B-cell immunodeficiency, distal limb anomalies, and urogenital malformations (BILU) [MIM:609296]: An autosomal dominant disorder characterized by humoral immunodeficiency with undetectable B cells, distal limb anomalies, dysmorphic facial features, and urogenital malformations. {ECO:0000269|PubMed:31409799, ECO:0000269|PubMed:32128574, ECO:0000269|PubMed:33459963}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
5.6.2.2
uniprot
proteins
function
FUNCTION: Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand. Plays a role in B-cell differentiation. {ECO:0000269|PubMed:10684600, ECO:0000269|PubMed:31409799, ECO:0000269|PubMed:32128574}.
uniprot
proteins
mass_dalton
183267
uniprot
proteins
mutagenesis
MUTAGEN 482; /note="E->Q: Strongly reduced enzyme activity."; /evidence="ECO:0000269|PubMed:10684600"; MUTAGEN 485; /note="S->A: Slightly reduced enzyme activity."; /evidence="ECO:0000269|PubMed:10684600"; MUTAGEN 508; /note="R->E: Slightly reduced enzyme activity."; /evidence="ECO:0000269|PubMed:10684600"; MUTAGEN 510; /note="K->E: Strongly reduced enzyme activity."; /evidence="ECO:0000269|PubMed:10684600"; MUTAGEN 515; /note="R->Q: Slightly reduced enzyme activity."; /evidence="ECO:0000269|PubMed:10684600
uniprot
proteins
post_translational_modification
PTM: (Microbial infection) Deubiquitinated by Epstein-Barr virus BPLF1; leading to stabilized SUMOylated TOP2A trapped in cleavage complexes, which halts the DNA damage response to TOP2A-induced double-strand DNA breaks. {ECO:0000269|PubMed:34543352}.; PTM: SUMOylated. {ECO:0000269|PubMed:34543352}.
uniprot
proteins
protein_family
Type II topoisomerase family
uniprot
proteins
pubmed
10095062
uniprot
proteins
pubmed
10684600
uniprot
proteins
pubmed
12821127
uniprot
proteins
pubmed
1333583
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17487921
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
17567603
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
2163884
uniprot
proteins
pubmed
21778401
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
2556712
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28343847
uniprot
proteins
pubmed
31409799
uniprot
proteins
pubmed
31953910
uniprot
proteins
pubmed
32128574
uniprot
proteins
pubmed
33459963
uniprot
proteins
pubmed
34543352
uniprot
proteins
pubmed
8299728
uniprot
proteins
pubmed
8383537
uniprot
proteins
pubmed
8396237
uniprot
proteins
pubmed
9155056
uniprot
proteins
pubmed
9168988
uniprot
proteins
sequence_length
1626
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:8299728, ECO:0000269|PubMed:9155056}. Nucleus, nucleoplasm {ECO:0000269|PubMed:9155056}. Nucleus {ECO:0000269|PubMed:19690332}.
uniprot
proteins