Peli2
entrez
93834
canonical
uniprot
Q8BST6
canonical
ensembl
ENSMUSG00000021846
resolver
ensp
ENSMUSP00000072894
resolver
ensp
ENSMUSP00000154661
resolver
enst
ENSMUST00000073150
resolver
genesymbol
Peli2
resolver
uniprot
E9QPQ6
resolver
uniprot
Q8C4F2
resolver
uniprot
Q8CC65
resolver
uniprot
Q8R2X4
resolver
uniprot
Q9ERJ7
resolver
uniprot_entry
E9QPQ6_MOUSE
resolver
uniprot_entry
PELI2_MOUSE
resolver
uniprot_sec
Q8C4F2
resolver
uniprot_sec
Q8CC65
resolver
uniprot_sec
Q8R2X4
resolver
uniprot_sec
Q9ERJ7
resolver
amino_acid_sequence
MFSPGQEEPSAPNKEPVKYRELVVLGYNGALPNGDRGRRKSRFALYKRTYASGVKPSTIHMVSTPQASKAISSRGHHSISYTLSRSQTVVVEYTHDKDTDMFQVGRSTESPIDFVVTDTVSGGQNEDAQITQSTISRFACRIVCDRNEPYTARIFAAGFDSSKNIFLGEKAAKWKNPDGHMDGLTTNGVLVMHPQGGFTEESQPGVWREISVCGDVYTLRETRSAQQRGKLVESETNVLQDGSLIDLCGATLLWRTADGLFHAPTQKHIEALRQEINAARPQCPVGLNTLAFPSINRKEVVEEKQPWAYLSCGHVHGYHSWGHRSDTEANERECPMCRTVGPYVPLWLGCEAGFYVDAGPPTHAFTPCGHVCSEKSAKYWSQIPLPHGTHAFHAACPFCATQLVGEQNCIKLIFQGPVD
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (By similarity). Specifically recognizes and binds proteins phosphorylated on threonine residues (By similarity). Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6 (PubMed:12370331, PubMed:22669975). Mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination (By similarity). Acts as a negative regulator of cGAS-STING signaling: recognizes and binds phosphorylated STING1 and mediates 'Lys-63'-linked polyubiquitination of TBK1, inhibiting cGAS-STING signaling, while simultaneously enhancing the STING1-dependent NF-kappa-B axis (By similarity). May be important for LPS- and IL1B-induced MAP3K7-dependent, but not MAP3K3-dependent, NF-kappa-B activation (By similarity). Can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1 (By similarity). {ECO:0000250|UniProtKB:Q9HAT8, ECO:0000269|PubMed:12370331, ECO:0000269|PubMed:22669975}.
uniprot
proteins
mass_dalton
46272
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9HAT8}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by IRAK1 and IRAK4 enhancing its E3 ligase activity. {ECO:0000250|UniProtKB:Q9HAT8}.
uniprot
proteins
protein_family
Pellino family
uniprot
proteins
pubmed
11306823
uniprot
proteins
pubmed
12370331
uniprot
proteins
pubmed
15213237
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
22669975
uniprot
proteins
sequence_length
419
uniprot
proteins