FXYD1
entrez
5348
canonical
uniprot
O00168
canonical
ensembl
ENSG00000266964
resolver
ensp
ENSP00000343314
resolver
ensp
ENSP00000393611
resolver
ensp
ENSP00000465289
resolver
ensp
ENSP00000466398
resolver
ensp
ENSP00000467727
resolver
ensp
ENSP00000468535
resolver
ensp
ENSP00000481244
resolver
ensp
ENSP00000544956
resolver
ensp
ENSP00000544957
resolver
ensp
ENSP00000544958
resolver
ensp
ENSP00000544960
resolver
ensp
ENSP00000544961
resolver
ensp
ENSP00000544962
resolver
ensp
ENSP00000544963
resolver
ensp
ENSP00000544964
resolver
ensp
ENSP00000544965
resolver
ensp
ENSP00000544966
resolver
ensp
ENSP00000544967
resolver
ensp
ENSP00000544968
resolver
ensp
ENSP00000544969
resolver
ensp
ENSP00000544971
resolver
ensp
ENSP00000544972
resolver
ensp
ENSP00000544973
resolver
ensp
ENSP00000544974
resolver
ensp
ENSP00000544975
resolver
ensp
ENSP00000544976
resolver
ensp
ENSP00000544977
resolver
ensp
ENSP00000544978
resolver
ensp
ENSP00000544980
resolver
ensp
ENSP00000544981
resolver
ensp
ENSP00000544982
resolver
ensp
ENSP00000544984
resolver
ensp
ENSP00000544985
resolver
ensp
ENSP00000544986
resolver
ensp
ENSP00000544987
resolver
ensp
ENSP00000774183
resolver
enst
ENST00000351325
resolver
enst
ENST00000455515
resolver
enst
ENST00000588081
resolver
enst
ENST00000588607
resolver
enst
ENST00000588715
resolver
enst
ENST00000589209
resolver
enst
ENST00000612146
resolver
enst
ENST00000874897
resolver
enst
ENST00000874898
resolver
enst
ENST00000874899
resolver
enst
ENST00000874901
resolver
enst
ENST00000874902
resolver
enst
ENST00000874903
resolver
enst
ENST00000874904
resolver
enst
ENST00000874905
resolver
enst
ENST00000874906
resolver
enst
ENST00000874907
resolver
enst
ENST00000874908
resolver
enst
ENST00000874909
resolver
enst
ENST00000874910
resolver
enst
ENST00000874912
resolver
enst
ENST00000874913
resolver
enst
ENST00000874914
resolver
enst
ENST00000874915
resolver
enst
ENST00000874916
resolver
enst
ENST00000874917
resolver
enst
ENST00000874918
resolver
enst
ENST00000874919
resolver
enst
ENST00000874921
resolver
enst
ENST00000874922
resolver
enst
ENST00000874923
resolver
enst
ENST00000874925
resolver
enst
ENST00000874926
resolver
enst
ENST00000874927
resolver
enst
ENST00000874928
resolver
genesymbol
FXYD1
resolver
genesymbol_syn
PLM
resolver
hgnc
HGNC:4025
resolver
uniprot
A8K196
resolver
uniprot_entry
PLM_HUMAN
resolver
uniprot_sec
A8K196
resolver
amino_acid_sequence
MASLGHILVFCVGLLTMAKAESPKEHDPFTYDYQSLQIGGLVIAGILFILGILIVLSRRCRCKFNQQQRTGEPDEEEGTFRSSIRRLSTRRR
uniprot
proteins
function
FUNCTION: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell. Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated. Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1. Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone. {ECO:0000250|UniProtKB:O08589, ECO:0000250|UniProtKB:P56513, ECO:0000250|UniProtKB:Q9Z239}.
uniprot
proteins
mass_dalton
10441
uniprot
proteins
mutagenesis
MUTAGEN 60; /note="C->S: Significantly reduced half-life; when associated with S-62."; /evidence="ECO:0000269|PubMed:21868384"; MUTAGEN 62; /note="C->S: Significantly reduced half-life; when associated with S-60."; /evidence="ECO:0000269|PubMed:21868384
uniprot
proteins
post_translational_modification
PTM: Major plasma membrane substrate for cAMP-dependent protein kinase (PKA) and protein kinase C (PKC) in several different tissues (By similarity). Phosphorylated in response to insulin and adrenergic stimulation (By similarity). Phosphorylation at Ser-88 stimulates sodium/potassium-transporting ATPase activity while the unphosphorylated form inhibits sodium/potassium-transporting ATPase activity (By similarity). Phosphorylation increases tetramerization, decreases binding to ATP1A1 and reduces inhibition of ATP1A1 activity (By similarity). Phosphorylation at Ser-83 leads to greatly reduced interaction with ATP1A1, ATP1A2 and ATP1A3 (By similarity). May be phosphorylated by DMPK (PubMed:10811636). {ECO:0000250|UniProtKB:O08589, ECO:0000250|UniProtKB:P56513, ECO:0000269|PubMed:10811636}.; PTM: Palmitoylation increases half-life and stability and is enhanced upon phosphorylation at Ser-88 by PKA. {ECO:0000269|PubMed:21868384}.
uniprot
proteins
protein_family
FXYD family
uniprot
proteins
pubmed
10811636
uniprot
proteins
pubmed
10950925
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16597826
uniprot
proteins
pubmed
17511473
uniprot
proteins
pubmed
21868384
uniprot
proteins
pubmed
9169143
uniprot
proteins
sequence_length
92
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P56513}; Single-pass type I membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:O08589}; Single-pass type I membrane protein {ECO:0000255}. Membrane, caveola {ECO:0000250|UniProtKB:O08589}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:O08589}. Note=Detected in the apical cell membrane in brain. In myocytes, localizes to sarcolemma, t-tubules and intercalated disks. {ECO:0000250|UniProtKB:O08589}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..56; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins