Cux1
entrez
116639
canonical
uniprot
P53565
canonical
ensembl
ENSRNOG00000001424
resolver
ensembl
ENSRNOG00055000274
resolver
ensembl
ENSRNOG00060011805
resolver
ensp
ENSRNOP00000040645
resolver
ensp
ENSRNOP00000056243
resolver
ensp
ENSRNOP00000080302
resolver
ensp
ENSRNOP00000089950
resolver
ensp
ENSRNOP00000103400
resolver
ensp
ENSRNOP00000104247
resolver
ensp
ENSRNOP00055000322
resolver
ensp
ENSRNOP00060015701
resolver
enst
ENSRNOT00000044841
resolver
enst
ENSRNOT00000112152
resolver
enst
ENSRNOT00000156078
resolver
enst
ENSRNOT00055000459
resolver
enst
ENSRNOT00060020018
resolver
genesymbol
Cux1
resolver
genesymbol_syn
Cdpl1
resolver
genesymbol_syn
Cutl1
resolver
uniprot
A0A8I6G4D0
resolver
uniprot
A0ABK0LL31
resolver
uniprot
F1LRC5
resolver
uniprot
F1M8J7
resolver
uniprot_entry
A0A8I6G4D0_RAT
resolver
uniprot_entry
A0ABK0LL31_RAT
resolver
uniprot_entry
CUX1_RAT
resolver
uniprot_entry
F1M8J7_RAT
resolver
uniprot_sec
F1LRC5
resolver
amino_acid_sequence
MAANVGSMFQYWKRFDLQQLQRELDATATVLANRQDESEQSRKRLIEQSREFKKNTPEDLRKQVAPLLKSFQGEIDALSKRSKEAEAAFLTVYKRLIDVPDPVPALDLGQQLEIKVQRLHDIETENQKLRETLEEYNKEFAEVKNQEVTIKALKEKIREYEQTLKSQAETIALEKEQKLQNDFAEKERKLQETQMSTTSKLEEAEHKLQTLQTALEKTRTELFDLKTKYDEETTAKADEIEMIMTDLERANQRAEVAQREAETLREQLSSANHSLQLASQIQKAPDVAIEVLTRSSLEVELAAKEREIAQLVEDVQRLQASLTKLRENSASQISQLEQQLNAKNSTLKQLEEKLKGQADYEDVKKELTTLKSMEFAPSEGAGTQDSTKPLEVLLLEKNRSLQSENATLRISNSDLSGSARRKGRDQPESRRPGPLPASPPPQLPRNTGEQVSNTNGTHHFSPAGLSQDFFSSNLASPSLPLASTGKFALNSLLQRQLMQSFYSKAMQEAGSTSTIFSTGPYSTNSISSPSPLQQSPDVNGMAPSPSQSESAGSISEGEEIDTAEIARQVKEQLIKHNIGQRIFGHYVLGLSQGSVSEILARPKPWNKLTVRGKEPFHKMKQFLSDEQNILALRSIQGRQRGNITTRIRASETGSDEAIKSILEQAKRELQVQKTAEPVQASSTASSGNSDDAIRSILQQARREMEAQQAALDPALKPAPLSQPDLTILNPKLLSASPMSTVSTYPPLAISLKKTPAAPEASTSALPSAPALKKEAQDAPTLDPPGSADATPGVLRPVKNELVRGSTWKDPWWNPVQPERRNLTTSEETKADETNASGKEKTGSSQPRAERSQLQGPSATAEYWKEWPNAESPYSQSSELSLTGASRSETPQNSPLPSSPIVPMAKPAKPSVPPLTPEQYEVYMYQEVDTIELTRQVKEKLAKNGICQRIFGEKVLGLSQGSVSDMLSRPKPWSKLTQKGREPFIRMQLWLNGELGQGVLPVQGQQQGPVLHSVTSLQDPLQQGCVSSESTPKTSASCSPAPESPMSSSESVKSLTELVQQPCPTIETSKEGKPPEPSDPPTSDSQPTTPLPLSGHSALSIQELVAMSPELDTYGITKRVKEVLTDNNLGQRLFGETILGLTQGSVSDLLARPKPWHKLSLKGREPFVRMQLWLNDPNNVEKLMDMKRMEKKAYMKRRHSSVSDSQPCEPPSVGIDYSQGASPQPQHQLKKPRVVLAPEEKEALKRAYQQKPYPSPKTIEELATQLNLKTSTVINWFHNYRSRIRRELFIEEIQAGSQGQAGASDSPSARSSRAAPSSEGDSCDGVEAADTEEPGGNIVATKSQGGPAEVTAAPADREEATQPAEKAKAQPLSSGTPGQDDGEDAGRSRPPPEGLADAPAPVPNLAAPAAGEDAATSATAPAMATEAPGAARAGPAERSSALPSTSAPANAPARRPSSLQSLFGLPEAAGARDNPVRKKKAANLNSIIHRLEKAASREEPIEWEF
uniprot
proteins
function
FUNCTION: Transcription factor involved in the control of neuronal differentiation in the brain. Regulates dendrite development and branching, and dendritic spine formation in cortical layers II-III. Also involved in the control of synaptogenesis. In addition, it has probably a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Binds to the TH enhancer; may require the basic helix-loop-helix protein TCF4 as a coactivator. {ECO:0000250|UniProtKB:P53564, ECO:0000269|PubMed:7913462}.; FUNCTION: [CDP/Cux p110]: Plays a role in cell cycle progression, in particular at the G1/S transition. As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa. While CUX1 only transiently binds to DNA and carries the CCAAT-displacement activity, CDP/Cux p110 makes a stable interaction with DNA and stimulates expression of genes such as POLA1. {ECO:0000250|UniProtKB:P39880}.
uniprot
proteins
mass_dalton
164541
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKA. {ECO:0000269|PubMed:7913462}.; PTM: As cells progress into S phase, a fraction of CUX1 molecules is proteolytically processed into N-terminally truncated proteins of 110 kDa by CTSL. Cell cycle-dependent processing of CUX1 serves to generate a CDP/Cux p110 with distinct DNA binding and transcriptional properties. {ECO:0000250|UniProtKB:P39880}.
uniprot
proteins
protein_family
CUT homeobox family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7913462
uniprot
proteins
sequence_length
1504
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P53564}.
uniprot
proteins