TYSND1
entrez
219743
canonical
uniprot
Q2T9J0
canonical
ensembl
ENSG00000156521
resolver
ensp
ENSP00000287078
resolver
ensp
ENSP00000335673
resolver
genesymbol
TYSND1
resolver
hgnc
HGNC:28531
resolver
uniprot
Q5SQT4
resolver
uniprot
Q5SQU1
resolver
uniprot
Q8N6H2
resolver
uniprot
Q96AR5
resolver
uniprot_entry
TYSD1_HUMAN
resolver
uniprot_sec
Q5SQT4
resolver
uniprot_sec
Q5SQU1
resolver
uniprot_sec
Q8N6H2
resolver
uniprot_sec
Q96AR5
resolver
amino_acid_sequence
MRRQWGSAMRAAEQAGCMVSASRAGQPEAGPWSCSGVILSRSPGLVLCHGGIFVPFLRAGSEVLTAAGAVFLPGDSCRDDLRLHVQWAPTAAGPGGGAERGRPGLCTPQCASLEPGPPAPSRGRPLQPRLPAELLLLLSCPAFWAHFARLFGDEAAEQWRFSSAARDDEVSEDEEADQLRALGWFALLGVRLGQEEVEEERGPAMAVSPLGAVPKGAPLLVCGSPFGAFCPDIFLNTLSCGVLSNVAGPLLLTDARCLPGTEGGGVFTARPAGALVALVVAPLCWKAGEWVGFTLLCAAAPLFRAARDALHRLPHSTAALAALLPPEVGVPWGLPLRDSGPLWAAAAVLVECGTVWGSGVAVAPRLVVTCRHVSPREAARVLVRSTTPKSVAIWGRVVFATQETCPYDIAVVSLEEDLDDVPIPVPAEHFHEGEAVSVVGFGVFGQSCGPSVTSGILSAVVQVNGTPVMLQTTCAVHSGSSGGPLFSNHSGNLLGIITSNTRDNNTGATYPHLNFSIPITVLQPALQQYSQTQDLGGLRELDRAAEPVRVVWRLQRPLAEAPRSKL
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids. {ECO:0000269|PubMed:22002062}.
uniprot
proteins
mass_dalton
59309
uniprot
proteins
mutagenesis
MUTAGEN 481; /note="S->A: Abrogates the self-cleaving activity of TYSND1."; /evidence="ECO:0000269|PubMed:22002062
uniprot
proteins
post_translational_modification
PTM: Self-cleavage gives rise to an N-terminal 15-kDa fragment and C-terminal 45-kDa fragment upon import into the peroxisomes. The full-length TYSND1 is the active the proteolytic processing of PTS1- and PTS2-proteins and in self-cleavage, and intermolecular self-cleavage of TYSND1 down-regulates its protease activity.
uniprot
proteins
protein_family
Peptidase S1B family
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22002062
uniprot
proteins
sequence_length
566
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:22002062}.
uniprot
proteins