Capza1
entrez
691149
canonical
uniprot
B2GUZ5
canonical
ensembl
ENSRNOG00000013538
resolver
ensembl
ENSRNOG00055019340
resolver
ensembl
ENSRNOG00060026811
resolver
ensembl
ENSRNOG00065031558
resolver
ensp
ENSRNOP00000094230
resolver
ensp
ENSRNOP00055026806
resolver
ensp
ENSRNOP00060039028
resolver
ensp
ENSRNOP00065044881
resolver
enst
ENSRNOT00000109484
resolver
enst
ENSRNOT00055033080
resolver
enst
ENSRNOT00060046931
resolver
enst
ENSRNOT00065054565
resolver
genesymbol
Capza1
resolver
uniprot_entry
CAZA1_RAT
resolver
amino_acid_sequence
MADFEDRVSDEEKVRIAAKFITHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNMDQFTPVKIEGYDDQVLITEHGDLGNSRFLDPRNKISFKFDHLRKEASDPQPEDVDGGLKSWRDSCDSALRAYVKDHYSNGFCTVYAKTIDGQQTIIACIESHQFQPKNFWNGRWRSEWKFTITPPTAQVVGVLKIQVHYYEDGNVQLVSHKDVQDSVTVSNEVQTAKEFIKIIESAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA
uniprot
proteins
function
FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions (By similarity). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A0PFK5, ECO:0000250|UniProtKB:P52907}.
uniprot
proteins
mass_dalton
32910
uniprot
proteins
protein_family
F-actin-capping protein alpha subunit family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19343716
uniprot
proteins
pubmed
19452629
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
286
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19343716}.
uniprot
proteins