TMEM106A
entrez
113277
canonical
uniprot
Q96A25
canonical
ensembl
ENSG00000184988
resolver
ensp
ENSP00000439835
resolver
ensp
ENSP00000439844
resolver
ensp
ENSP00000466820
resolver
ensp
ENSP00000483246
resolver
ensp
ENSP00000546835
resolver
ensp
ENSP00000629800
resolver
ensp
ENSP00000629802
resolver
enst
ENST00000536052
resolver
enst
ENST00000876776
resolver
enst
ENST00000959741
resolver
enst
ENST00000959743
resolver
genesymbol
TMEM106A
resolver
hgnc
HGNC:28288
resolver
uniprot
A0ACI8RVQ5
resolver
uniprot
A8K2X2
resolver
uniprot
B7Z698
resolver
uniprot
B7Z779
resolver
uniprot_entry
A0ACI8RVQ5_HUMAN
resolver
uniprot_entry
B7Z779_HUMAN
resolver
uniprot_entry
T106A_HUMAN
resolver
uniprot_sec
A8K2X2
resolver
uniprot_sec
B7Z698
resolver
amino_acid_sequence
MGKTFSQLGSWREDENKSILSSKPAIGSKAVNYSSTGSSKSFCSCVPCEGTADASFVTCPTCQGSGKIPQELEKQLVALIPYGDQRLKPKHTKLFVFLAVLICLVTSSFIVFFLFPRSVIVQPAGLNSSTVAFDEADIYLNITNILNISNGNYYPIMVTQLTLEVLHLSLVVGQVSNNLLLHIGPLASEQMFYAVATKIRDENTYKICTWLEIKVHHVLLHIQGTLTCSYLSHSEQLVFQSYEYVDCRGNASVPHQLTPHPP
uniprot
proteins
function
FUNCTION: Activates macrophages and polarizes them into M1-like macrophages through the activation of the MAPK and NF-kappaB signaling pathway. Upon activation, up-regulates the expression of CD80, CD86, CD69 and MHC II on macrophages, and induces the release of pro-inflammatory cytokines such as TNF, IL1B, IL6, CCL2 and nitric oxide (By similarity). May play a role in inhibition of proliferation and migration (PubMed:29131025, PubMed:30456879). {ECO:0000250|UniProtKB:Q8VC04, ECO:0000269|PubMed:29131025, ECO:0000269|PubMed:30456879}.
uniprot
proteins
mass_dalton
28920
uniprot
proteins
protein_family
TMEM106 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
29131025
uniprot
proteins
pubmed
30456879
uniprot
proteins
sequence_length
262
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8VC04}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 95..115; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins