Tmem106b
entrez
71900
canonical
uniprot
Q80X71
canonical
ensembl
ENSMUSG00000029571
resolver
ensp
ENSMUSP00000031556
resolver
ensp
ENSMUSP00000209586
resolver
enst
ENSMUST00000031556
resolver
genesymbol
Tmem106b
resolver
uniprot
Q9D737
resolver
uniprot_entry
T106B_MOUSE
resolver
uniprot_sec
Q9D737
resolver
amino_acid_sequence
MGKSLSHLPLHSNKEDGYDGVTSTDNMRNGLVSSEVHNEDGRNGDVSQFPYVEFTGRDSVTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMASVFVCLLLSGLAVFFLFPRSIEVKYIGVKSAYVSYDAEKRTIYLNITNTLNITNNNYYSVEVENITAQVQFSKTVIGKARLNNITNIGPLDMKQIDYTVPTVIAEEMSYMYDFCTLLSIKVHNIVLMMQVTVTTAYFGHSEQISQERYQYVDCGRNTTYQLAQSEYLNVLQPQQ
uniprot
proteins
function
FUNCTION: In neurons, involved in the transport of late endosomes/lysosomes (PubMed:25066864, PubMed:32160553). May be involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking (PubMed:25066864). May act as a molecular brake for retrograde transport of late endosomes/lysosomes, possibly via its interaction with MAP6 (By similarity). In motoneurons, may mediate the axonal transport of lysosomes and axonal sorting at the initial segment (PubMed:32160553). It remains unclear whether TMEM106B affects the transport of moving lysosomes in the anterograde or retrograde direction in neurites and whether it is particularly important in the sorting of lysosomes in axons or in dendrites (Probable). In neurons, may also play a role in the regulation of lysosomal size and responsiveness to stress (PubMed:25066864). Required for proper lysosomal acidification (PubMed:28728022). {ECO:0000250|UniProtKB:Q6AYA5, ECO:0000269|PubMed:25066864, ECO:0000269|PubMed:28728022, ECO:0000269|PubMed:32160553, ECO:0000305|PubMed:32160553}.
uniprot
proteins
mass_dalton
31172
uniprot
proteins
protein_family
TMEM106 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
23136129
uniprot
proteins
pubmed
25066864
uniprot
proteins
pubmed
28728022
uniprot
proteins
pubmed
29855382
uniprot
proteins
pubmed
32160553
uniprot
proteins
pubmed
32761777
uniprot
proteins
pubmed
32852886
uniprot
proteins
pubmed
32929860
uniprot
proteins
sequence_length
275
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:23136129, ECO:0000269|PubMed:25066864}; Single-pass type II membrane protein. Lysosome membrane {ECO:0000269|PubMed:23136129, ECO:0000269|PubMed:25066864}; Single-pass type II membrane protein. Cell membrane {ECO:0000250|UniProtKB:Q9NUM4}; Single-pass type II membrane protein {ECO:0000255}. Note=Colocalizes with LAMP1. A small fraction resides on the cell surface (By similarity). {ECO:0000250|UniProtKB:Q9NUM4, ECO:0000269|PubMed:23136129, ECO:0000269|PubMed:25066864}.
uniprot
proteins
transmembrane_region
TRANSMEM 98..118; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins