Alox12b
entrez
287425
canonical
uniprot
Q2KMM4
canonical
ensembl
ENSRNOG00000022210
resolver
ensembl
ENSRNOG00055032640
resolver
ensembl
ENSRNOG00060020609
resolver
ensp
ENSRNOP00000033009
resolver
ensp
ENSRNOP00055046498
resolver
ensp
ENSRNOP00060029361
resolver
enst
ENSRNOT00055056392
resolver
enst
ENSRNOT00060035699
resolver
genesymbol
Alox12b
resolver
uniprot
Q2KMM5
resolver
uniprot_entry
LX12B_RAT
resolver
uniprot_sec
Q2KMM5
resolver
activity_regulation
ACTIVITY REGULATION: Increased by calcium. {ECO:0000250|UniProtKB:O70582}.
uniprot
proteins
amino_acid_sequence
MATYKVKVATGTDFFSGTLDSISLTIVGTQGESHKQRLNHFGRDFATGAVDDYTVQCQQDLGELIIIRLHKEPHSFLPKDPWYCNYVQICAPNCRVYHFPAYQWMDGYETLSLREATGKTTADDTLPILLEHRQEEIRAKKDFYHWRVFVPGLPNYVDIPSYHPPPRRCRNPNRPEWNGYIPGFPILINIKATRFLNLNLRFSFVKTASFFYRLGPMALAFKLRGLVDRKRSWKRLKDIKNIFPATKTVVSEYVAEHWTEDSFFGYQYLNGINPGHIRRCMQIPDKFPVTDEMVAPFLGEGTCLQAELEKGNIYLADYRILDGIPTVELNGQKQHHCAPICLLHFGPDGNMMPIAIQLSQTPGPDCPIFLPNDSEWDWLLAKTWVRYAEFYSHEAVAHLLESHLIGEAFCLALLRNLPMCHPLYKLLIPHTRYNVQINSIGRALLLNKGGLSARAMSLGLEGFAQVMVRGLSELTYKSLCIPNDFVERGVQDLPGYYFRDDSLAVWYAMERYVTEIITYYYPNDAAVEGDPELQCWVQEIFKECLLERESSGFPTCLRTVPELIEYVTMVMYTCSARHAAVNTGQLEYTSWMPNFPSSMRNPPMQSKGLTTLQTFMDTLPDVKTTCIVLLVLWTLCREPDDRRPLGHFPDIHFVEEAPRRSMEAFRQNLNQISHNIRQRNKCLNLPYYYLDPVLIENSISI
uniprot
proteins
ec_number
1.13.11.-
uniprot
proteins
function
FUNCTION: Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:23382512). In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins (By similarity). {ECO:0000250|UniProtKB:O75342, ECO:0000269|PubMed:23382512}.
uniprot
proteins
mass_dalton
80741
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis.; PATHWAY: Lipid metabolism; sphingolipid metabolism.
uniprot
proteins
protein_family
Lipoxygenase family
uniprot
proteins
pubmed
15222128
uniprot
proteins
pubmed
23382512
uniprot
proteins
sequence_length
701
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00726}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O75342}.
uniprot
proteins