Alkbh4
entrez
72041
canonical
uniprot
Q9D8F1
canonical
ensembl
ENSMUSG00000039754
resolver
ensp
ENSMUSP00000040403
resolver
ensp
ENSMUSP00000098134
resolver
genesymbol
Alkbh4
resolver
uniprot
Q8R1Y9
resolver
uniprot_entry
ALKB4_MOUSE
resolver
uniprot_sec
Q8R1Y9
resolver
amino_acid_sequence
MAAAAEVSLLQECGCKGIRTCLICERQRHRDPPWQICLQKKCCFLYCPDTGWAAGAEGSDLEGWAFPFPGVTLIQDFVTPEEEAEMVRLMDCDPWKLSQSGRKKQDYGPKVNFRKQKLKMAGFQGLPGFSQKVVQRMGLYPGLEDFQPVEQCNLDYSPERGSAIDPHLDDAWLWGERLVSLNLLSATVVSMSPEAPGSLLLCSAPSVRPDAFEDSLVAPSRSVPCQEVEVAITVPRRSLLVLTGAARHQWTHAIHRRHIKARRVCATFRELSSEFLPGGKQQELGQELLQAALSFQGRPV
uniprot
proteins
ec_number
1.14.11.-
uniprot
proteins
ec_number
1.14.11.51
uniprot
proteins
function
FUNCTION: Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes (By similarity). Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration (By similarity). In addition to proteins, also demethylates DNA: specifically demethylates DNA methylated on the 6th position of adenine (N(6)-methyladenosine) DNA, thereby regulating Polycomb silencing (PubMed:30982744). {ECO:0000250|UniProtKB:Q9NXW9, ECO:0000269|PubMed:30982744}.
uniprot
proteins
mass_dalton
33394
uniprot
proteins
protein_family
AlkB family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23673617
uniprot
proteins
pubmed
25153837
uniprot
proteins
pubmed
30982744
uniprot
proteins
sequence_length
300
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9NXW9}. Nucleus {ECO:0000269|PubMed:25153837}. Nucleus, nucleolus {ECO:0000269|PubMed:25153837}. Midbody {ECO:0000250|UniProtKB:Q9NXW9}. Note=Associates with the contractile ring and midbody. {ECO:0000250|UniProtKB:Q9NXW9}.
uniprot
proteins