Ngdn
entrez
68966
canonical
uniprot
Q9DB96
canonical
ensembl
ENSMUSG00000022204
resolver
ensp
ENSMUSP00000022815
resolver
enst
ENSMUST00000022815
resolver
genesymbol
Ngdn
resolver
genesymbol_syn
Ngd
resolver
uniprot
Q8CIJ2
resolver
uniprot_entry
NGDN_MOUSE
resolver
uniprot_sec
Q8CIJ2
resolver
amino_acid_sequence
MAAPEVLESDVSSSITLLKNLQEQVMAVTAQIQALTTKVRAGTYSTEKGLSFLEVKDQLLLMYLMDLSHLILDKASGASLQGHPAVLRLVEIRTVLEKLRPLDQKLKYQIDKLVKTAVTGSLSENDPLRFKPHPSNMVSKLSSEDEEESEAEEGQSEASGKKSAKGSAKKYVPPRLVPVHYDETEAEREQKRLEKAKRRALSSSVIRELKEQYSDAPEEIRDARHPHVTRQSQEDQHRVNYEESMMVRLSVSKREKGLRRRASAMSSQLHSLTHFSDISALTGGTAHLDEDQNPVKKRKKLPKKGRKKKGFRRRW
uniprot
proteins
function
FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Its dissociation from the complex determines the transition from state pre-A1 to state pre-A1* (By similarity). Inhibits mRNA translation in a cytoplasmic polyadenylation element (CPE)-dependent manner (PubMed:16705177). {ECO:0000250|UniProtKB:Q8NEJ9, ECO:0000269|PubMed:16705177}.
uniprot
proteins
mass_dalton
35659
uniprot
proteins
protein_family
SAS10 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16705177
uniprot
proteins
sequence_length
315
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16705177}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q8NEJ9}. Chromosome, centromere {ECO:0000250|UniProtKB:Q8NEJ9}. Cytoplasm {ECO:0000269|PubMed:16705177}. Cell projection, axon {ECO:0000269|PubMed:16705177}. Cell projection, dendrite {ECO:0000269|PubMed:16705177}. Cell projection, filopodium {ECO:0000269|PubMed:16705177}. Note=Translocated from nucleolus to nuclear foci in response to UV damage (By similarity). Detected in axons, dendrites and filopodia. Colocalized with EIF4E in neurites. {ECO:0000250}.
uniprot
proteins