Cd209a
entrez
170786
canonical
uniprot
Q91ZX1
canonical
ensembl
ENSMUSG00000031494
resolver
ensp
ENSMUSP00000012847
resolver
genesymbol
Cd209a
resolver
genesymbol_syn
Cire
resolver
uniprot
Q3TAT9
resolver
uniprot
Q91ZW5
resolver
uniprot_entry
C209A_MOUSE
resolver
uniprot_sec
Q3TAT9
resolver
uniprot_sec
Q91ZW5
resolver
amino_acid_sequence
MSDSKEMGKRQLRPLDEELLTSSHTRHSIKGFGFQTNSGFSSFTGCLVHSQVPLALQVLFLAVCSVLLVVILVKVYKIPSSQEENNQMNVYQELTQLKAGVDRLCRSCPWDWTHFQGSCYFFSVAQKSWNDSATACHNVGAQLVVIKSDEEQNFLQQTSKKRGYTWMGLIDMSKESTWYWVDGSPLTLSFMKYWSKGEPNNLGEEDCAEFRDDGWNDTKCTNKKFWICKKLSTSCPSK
uniprot
proteins
function
FUNCTION: Probable pathogen-recognition receptor. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. May recognize in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. {ECO:0000250|UniProtKB:Q9NNX6}.; FUNCTION: On dendritic cells (DCs) it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Forms a first contact between DC and resting T cell, througth ICAM3 binding, facilitating the downstream DC-T cell clustering process and DC-induced proliferation of resting T Cells. {ECO:0000250|UniProtKB:Q9NNX6}.
uniprot
proteins
mass_dalton
27149
uniprot
proteins
pubmed
11581173
uniprot
proteins
pubmed
11684292
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
238
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane raft {ECO:0000250|UniProtKB:Q9NNX6}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9NNX6}.
uniprot
proteins
transmembrane_region
TRANSMEM 52..72; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins