Trpc5
entrez
22067
canonical
uniprot
Q9QX29
canonical
ensembl
ENSMUSG00000041710
resolver
ensp
ENSMUSP00000049063
resolver
enst
ENSMUST00000040184
resolver
genesymbol
Trpc5
resolver
genesymbol_syn
Trp5
resolver
genesymbol_syn
Trrp5
resolver
uniprot
Q2KHN9
resolver
uniprot
Q61059
resolver
uniprot
Q8C8A8
resolver
uniprot
Q9QWT1
resolver
uniprot
Q9R0D4
resolver
uniprot_entry
Q2KHN9_MOUSE
resolver
uniprot_entry
Q8C8A8_MOUSE
resolver
uniprot_entry
TRPC5_MOUSE
resolver
uniprot_sec
Q61059
resolver
uniprot_sec
Q9QWT1
resolver
uniprot_sec
Q9R0D4
resolver
activity_regulation
ACTIVITY REGULATION: Activated by G protein-coupled receptors via direct interaction with GTP-bound GNAI3, which increases the channel sensitivity to phosphatidylinositol bisphosphate (By similarity). May be activated by intracellular calcium store depletion. Calcium channel activity is enhanced by MYLK, that promotes its subcellular localization at the plasma membrane. {ECO:0000250|UniProtKB:Q9UL62}.
uniprot
proteins
amino_acid_sequence
MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLSAVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRKPSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRHNLRSFTERHADSLIQNQHYQEVIRNLVKRYVAAMIRNSKTNEGLTEENFKELKQDISSFRYEVLDLLGNRKHPRRSLSTSSADFSQRDDTNDGSGGARAKSKSVSFNVGCKKKACHGAPLIRTVPRASGAQGKPKSESSSKRSFMGPSFKKLGLFFSKFNGQTSEPTSEPMYTISDGIAQQHCMWQDIRYSQMEKGKAEACSQSQMNLGEVELGEIRGAAARSSECPLACSSSLHCASGICSSNSKLLDSSEDVFETWGEACDLLMHKWGDGQEEQVTTRL
uniprot
proteins
function
FUNCTION: Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:9553080). Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (PubMed:32110987). Acts on distinct neuronal populations in the hypothalamus to regulate innate behaviors including feeding, anxiety (flight/fight/fear), socialization and maternal care (PubMed:38959890). {ECO:0000250|UniProtKB:Q9UL62, ECO:0000269|PubMed:32110987, ECO:0000269|PubMed:38959890, ECO:0000269|PubMed:9553080}.
uniprot
proteins
mass_dalton
111458
uniprot
proteins
mutagenesis
MUTAGEN 34; /note="Missing: Male knockin mice exhibit obesity, anxiety, increased arousal, and reduced sociability. Females exhibit depression-like behavior postpartum, anhedonia and impaired maternal-offspring interactions."; /evidence="ECO:0000269|PubMed:38959890
uniprot
proteins
protein_family
STrpC subfamily
uniprot
proteins
protein_family
TRPC5 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
pubmed
10980202
uniprot
proteins
pubmed
15895247
uniprot
proteins
pubmed
20458742
uniprot
proteins
pubmed
32110987
uniprot
proteins
pubmed
38959890
uniprot
proteins
pubmed
8646775
uniprot
proteins
pubmed
9553080
uniprot
proteins
pubmed
9687496
uniprot
proteins
sequence_length
975
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9UL62}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UL62}.
uniprot
proteins
transmembrane_region
TRANSMEM 364..384; /note="Helical; Name=S1"; /evidence="ECO:0000250|UniProtKB:Q9UL62"; TRANSMEM 405..419; /note="Helical; Name=S2"; /evidence="ECO:0000250|UniProtKB:Q9UL62"; TRANSMEM 434..454; /note="Helical; Name=S3"; /evidence="ECO:0000250|UniProtKB:Q9UL62"; TRANSMEM 477..497; /note="Helical; Name=S4"; /evidence="ECO:0000250|UniProtKB:Q9UL62"; TRANSMEM 513..535; /note="Helical; Name=S5"; /evidence="ECO:0000250|UniProtKB:Q9UL62"; TRANSMEM 604..624; /note="Helical; Name=S6"; /evidence="ECO:0000250|UniProtKB:Q9UL62
uniprot
proteins