Atad3a
entrez
108888
canonical
uniprot
Q925I1
canonical
ensembl
ENSMUSG00000029036
resolver
ensp
ENSMUSP00000030903
resolver
genesymbol
Atad3a
resolver
genesymbol_syn
Atad3
resolver
genesymbol_syn
Kiaa1273
resolver
uniprot
A2AD89
resolver
uniprot
Q3TA78
resolver
uniprot
Q3UE74
resolver
uniprot
Q69ZM7
resolver
uniprot
Q8C6C6
resolver
uniprot_entry
ATD3A_MOUSE
resolver
uniprot_sec
A2AD89
resolver
uniprot_sec
Q3TA78
resolver
uniprot_sec
Q3UE74
resolver
uniprot_sec
Q69ZM7
resolver
uniprot_sec
Q8C6C6
resolver
amino_acid_sequence
MSWLFGIKGPKGEGTGPPLPLPPAQPGAEGGGDRGAGDRPSPKDKWSNFDPTGLERAAKAARELEHSRHAKEALSLAQMQEQTLQLEQQSKLKEYEAAVEQLKSEQIRVQAEERRKTLTEETRQHQARAQYQDKLARQRYEDQLKQQQLLNEENLRKQEESVQKQEAIRRATVEREMELRHKNEMLRVEAEARARAKADRENADIIREQIRLKAAEHRQTILESIRTAGTLLGEGFRAFVTDWDKVTATVAGLTLLAVGVYSAKNATSVAGRYIEARLGKPSLVRETSRISVLEALRHPIQVSRRLVSRPQDALEGVILSPSLEARVRDIAIATRNTKKNKSLYRNVLMYGPPGTGKTLFAKKLALHSGMDYAIMTGGDVAPMGREGVTAMHKVFDWASTSRRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLHRTGQHSSKFMLVLASNQPEQFDWAINDRIDEMVCFALPQREERERLVRMYFDKYVLKPATEGKQRLKVAQFDYGKKCSEVAQLTEGMSGREIAQLAVAWQAMAYSSEDGVLTEAMMDARVQDAVQQHQQKMQWLKVERPDSQTNKPPHPSLLSC
uniprot
proteins
ec_number
3.6.1.-
uniprot
proteins
function
FUNCTION: Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important role in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis. Involved in mitochondrial-mediated antiviral innate immunity. Required to protect mitochondria from the PERK-mediated unfolded protein response: specifically inhibits the activity of EIF2AK3/PERK at mitochondria-endoplasmic reticulum contact sites, thereby providing a safe haven for mitochondrial protein translation during endoplasmic reticulum stress. Ability to inhibit EIF2AK3/PERK is independent of its ATPase activity. Also involved in the mitochondrial DNA damage response by promoting signaling between damaged genomes and the mitochondrial membrane, leading to activation of the integrated stress response (ISR). {ECO:0000250|UniProtKB:Q9NVI7}.
uniprot
proteins
mass_dalton
66742
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
pubmed
12865426
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20332122
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
591
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9NVI7}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9NVI7}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250|UniProtKB:Q9NVI7}. Note=In the mitochondrial inner membrane, enriched in sites with the potential to form contacts with the outer membrane. The N-terminal domain interacts with the inner surface of the mitochondrial outer membrane and the C-terminal domain localizes in a specific matrix compartment, where it is associated with nucleoids. Also present at mitochondria-endoplasmic reticulum contact sites; where it interacts with EIF2AK3/PERK. {ECO:0000250|UniProtKB:Q9NVI7}.
uniprot
proteins
transmembrane_region
TRANSMEM 246..263; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins