Tmem106b
entrez
312132
canonical
uniprot
Q6AYA5
canonical
ensembl
ENSRNOG00000006206
resolver
ensembl
ENSRNOG00055018227
resolver
ensembl
ENSRNOG00060000777
resolver
ensembl
ENSRNOG00065007535
resolver
ensp
ENSRNOP00000008677
resolver
ensp
ENSRNOP00055024881
resolver
ensp
ENSRNOP00060000262
resolver
ensp
ENSRNOP00065008632
resolver
enst
ENSRNOT00000008677
resolver
enst
ENSRNOT00055030896
resolver
enst
ENSRNOT00060000937
resolver
enst
ENSRNOT00065011800
resolver
genesymbol
Tmem106b
resolver
uniprot_entry
T106B_RAT
resolver
amino_acid_sequence
MGKSLSHLPLHSNKEDGYDGVTSTDNMRNGLVSSEVRNEDGRSGDVSQFPYVEFTGRDSVTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMASVFVCLLLSGLAVFFLFPRSIDVKYIGVKSAYVSYDSQKRMIYLNITNTLNITNNNYYSVEVENITAQVQFSKTVIGKARLSNITNIGPLDMKQIDYTVPTVIAEEMSYMYDFCTLPSIKVHNIVLMMQVTVTTAYFGHSEQISQERYQYVDCGRNTTYQLAQSEYLNVLQPQQ
uniprot
proteins
function
FUNCTION: Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking. May act as a molecular brake for retrograde transport of late endosomes/lysosomes, possibly via its interaction with MAP6 (PubMed:24357581). In neurons, may also play a role in the regulation of lysosomal size and responsiveness to stress (By similarity). Required for proper lysosomal acidification (By similarity). {ECO:0000250|UniProtKB:Q80X71, ECO:0000269|PubMed:24357581}.; FUNCTION: In neurons, involved in the transport of late endosomes/lysosomes (PubMed:24357581). May be involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking (PubMed:24357581). May act as a molecular brake for retrograde transport of late endosomes/lysosomes, possibly via its interaction with MAP6 (PubMed:24357581). In motoneurons, may mediate the axonal transport of lysosomes and axonal sorting at the initial segment (By similarity). It remains unclear whether TMEM106B affects the transport of moving lysosomes in the anterograde or retrograde direction in neurites and whether it is particularly important in the sorting of lysosomes in axons or in dendrites (By similarity). In neurons, may also play a role in the regulation of lysosomal size and responsiveness to stress (By similarity). Required for proper lysosomal acidification (By similarity). {ECO:0000250|UniProtKB:Q80X71, ECO:0000269|PubMed:24357581}.
uniprot
proteins
mass_dalton
31152
uniprot
proteins
protein_family
TMEM106 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24090084
uniprot
proteins
pubmed
24357581
uniprot
proteins
sequence_length
275
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:24357581}; Single-pass type II membrane protein {ECO:0000269|PubMed:24357581}. Lysosome membrane {ECO:0000269|PubMed:24357581}; Single-pass type II membrane protein {ECO:0000269|PubMed:24357581}. Cell membrane {ECO:0000250|UniProtKB:Q9NUM4}; Single-pass type II membrane protein {ECO:0000255}. Note=Colocalizes with LAMP1 (PubMed:24357581). A small fraction resides on the cell surface (By similarity). {ECO:0000250|UniProtKB:Q9NUM4, ECO:0000269|PubMed:24357581}.
uniprot
proteins
transmembrane_region
TRANSMEM 98..118; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins