Ttll1
entrez
319953
canonical
uniprot
Q91V51
canonical
ensembl
ENSMUSG00000022442
resolver
ensp
ENSMUSP00000016897
resolver
ensp
ENSMUSP00000105106
resolver
ensp
ENSMUSP00000196781
resolver
ensp
ENSMUSP00000361935
resolver
enst
ENSMUST00000016897
resolver
enst
ENSMUST00000109480
resolver
genesymbol
Ttll1
resolver
uniprot
Q3TGC8
resolver
uniprot
Q543S4
resolver
uniprot
Q8C0A2
resolver
uniprot
Q91ZG1
resolver
uniprot_entry
TTLL1_MOUSE
resolver
uniprot_sec
Q3TGC8
resolver
uniprot_sec
Q543S4
resolver
uniprot_sec
Q8C0A2
resolver
uniprot_sec
Q91ZG1
resolver
amino_acid_sequence
MAGRVKWVTDIEKSVLINNFEKRGWIQVTENEDWNFYWMSVQTIRNVFSVETGYRLSDDQIVNHFPNHYELTRKDLMVKNIKRYRKELEKEGSPLAEKDENGKYLYLDFVPVTYMLPADYNLFVEEFRKSPSSTWIMKPCGKAQGKGIFLINKLSQIKKWSRDSKTSSFVSQSTKEAYVISVYINNPLLIGGRKFDLRLYVLVSTYRPLRCYMYKLGFCRFCTVKYTPSTSELDNMFVHLTNVAIQKHGEDYNHIHGGKWTVNNLRLYLESTRGREVTSKLFDEIHWIIVQSLKAVAPVMNNDKHCFECYGYDIIIDDKLKPWLIEVNASPSLTSSTANDRILKYNLINDTLNIAVPNGEIPDCKWNKSPPKEVLGNYEILYDEELAQGDGAERELRNRPGQPVGPRAGRSRDSGRSVLTTWK
uniprot
proteins
ec_number
6.3.2.-
uniprot
proteins
function
FUNCTION: Catalytic subunit of a polyglutamylase complex which modifies tubulin, generating side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin (PubMed:15890843). Probably involved in the side-chain elongation step of the polyglutamylation reaction rather than the initiation step (Probable). Modifies both alpha- and beta-tubulins with a preference for the alpha-tail (PubMed:15890843, PubMed:22170066). Unlike most polyglutamylases of the tubulin--tyrosine ligase family, only displays a catalytic activity when in complex with other proteins as it is most likely lacking domains important for autonomous activity (PubMed:15890843). Part of the neuronal tubulin polyglutamylase complex (PubMed:15890843). Mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility (PubMed:20442420, PubMed:20498047, PubMed:23897886). Involved in respiratory motile cilia function through the regulation of beating asymmetry (PubMed:20442420, PubMed:20498047). Essential for sperm flagella biogenesis, motility and male fertility (PubMed:20442420). Also mediates glutamylation of non-tubulin proteins (PubMed:29593216). Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis (PubMed:29593216). {ECO:0000269|PubMed:15890843, ECO:0000269|PubMed:20442420, ECO:0000269|PubMed:20498047, ECO:0000269|PubMed:22170066, ECO:0000269|PubMed:23897886, ECO:0000269|PubMed:29593216, ECO:0000305|Ref.11}.
uniprot
proteins
mass_dalton
49110
uniprot
proteins
protein_family
Tubulin polyglutamylase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15890843
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17499049
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20442420
uniprot
proteins
pubmed
20498047
uniprot
proteins
pubmed
22170066
uniprot
proteins
pubmed
23897886
uniprot
proteins
pubmed
29593216
uniprot
proteins
sequence_length
423
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17499049, ECO:0000269|PubMed:20498047}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:17499049}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000305|PubMed:20498047}. Cell projection, cilium, flagellum {ECO:0000305|PubMed:20442420}.
uniprot
proteins