Slc2a4
entrez
20528
canonical
uniprot
P14142
canonical
ensembl
ENSMUSG00000018566
resolver
ensp
ENSMUSP00000018710
resolver
enst
ENSMUST00000018710
resolver
genesymbol
Slc2a4
resolver
genesymbol_syn
Glut4
resolver
uniprot
Q3TPK6
resolver
uniprot
Q9JJN9
resolver
uniprot_entry
GLUT4_MOUSE
resolver
uniprot_sec
Q3TPK6
resolver
uniprot_sec
Q9JJN9
resolver
amino_acid_sequence
MPSGFQQIGSDDGEPPRQRVTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNATWLGRQGPGGPDSIPQGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLANNVLAVLGGALMGLANAAASYEILILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILVAQVLGLESMLGTATLWPLLLALTVLPALLQLILLPFCPESPRYLYIIRNLEGPARKSLKRLTGWADVSDALAELKDEKRKLERERPMSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFESAGVGQPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTCNFIVGMGFQYVADAMGPYVFLLFAVLLLGFFIFTFLKVPETRGRTFDQISAAFRRTPSLLEQEVKPSTELEYLGPDEND
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Slc2a4 may be the cause of certain post-receptor defects in non-insulin-dependent diabetes mellitus (NIDDM).
uniprot
proteins
function
FUNCTION: Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation (PubMed:26240143, PubMed:26629404). Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells (PubMed:26240143, PubMed:26629404). Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell (PubMed:26240143, PubMed:26629404). {ECO:0000269|PubMed:26240143, ECO:0000269|PubMed:26629404}.
uniprot
proteins
mass_dalton
54755
uniprot
proteins
post_translational_modification
PTM: Sumoylated. {ECO:0000250|UniProtKB:P14672}.; PTM: Palmitoylated. Palmitoylation by ZDHHC7 controls the insulin-dependent translocation of GLUT4 to the plasma membrane. {ECO:0000250|UniProtKB:P14672}.
uniprot
proteins
protein_family
Glucose transporter subfamily
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Sugar transporter (TC 2.A.1.1) family
uniprot
proteins
pubmed
10952468
uniprot
proteins
pubmed
12637568
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21907143
uniprot
proteins
pubmed
25586176
uniprot
proteins
pubmed
26240143
uniprot
proteins
pubmed
2654938
uniprot
proteins
pubmed
26629404
uniprot
proteins
pubmed
27354378
uniprot
proteins
pubmed
27739494
uniprot
proteins
sequence_length
509
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21907143, ECO:0000269|PubMed:25586176, ECO:0000269|PubMed:26240143, ECO:0000269|PubMed:26629404, ECO:0000269|PubMed:27739494}; Multi-pass membrane protein {ECO:0000269|PubMed:21907143}. Endomembrane system {ECO:0000269|PubMed:26240143, ECO:0000269|PubMed:26629404}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:26240143, ECO:0000269|PubMed:26629404, ECO:0000269|PubMed:27354378}. Note=Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized (PubMed:26240143, PubMed:26629404, PubMed:27354378). The dileucine internalization motif is critical for intracellular sequestration (PubMed:26240143, PubMed:26629404). Insulin stimulation induces translocation to the cell membrane (PubMed:27739494). {ECO:0000269|PubMed:26240143, ECO:0000269|PubMed:26629404, ECO:0000269|PubMed:27354378, ECO:0000269|PubMed:27739494}.
uniprot
proteins
transmembrane_region
TRANSMEM 24..44; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 81..101; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 111..131; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 142..162; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 171..191; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 201..221; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 287..307; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 323..343; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 353..373; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 385..405; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 417..437; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 445..465; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins