KCNJ10
entrez
3766
canonical
uniprot
P78508
canonical
ensembl
ENSG00000177807
resolver
ensp
ENSP00000491250
resolver
ensp
ENSP00000492619
resolver
ensp
ENSP00000495557
resolver
ensp
ENSP00000539202
resolver
enst
ENST00000638728
resolver
enst
ENST00000638868
resolver
enst
ENST00000644903
resolver
enst
ENST00000869143
resolver
genesymbol
KCNJ10
resolver
hgnc
HGNC:6256
resolver
uniprot
A3KME7
resolver
uniprot
Q5VUT9
resolver
uniprot
Q8N4I7
resolver
uniprot
Q92808
resolver
uniprot_entry
KCJ10_HUMAN
resolver
uniprot_sec
A3KME7
resolver
uniprot_sec
Q5VUT9
resolver
uniprot_sec
Q8N4I7
resolver
uniprot_sec
Q92808
resolver
activity_regulation
ACTIVITY REGULATION: Channel activity is strongly regulated by variations of cytosolic pH; channels are activated by alkaline and inhibited by acidic pH values (PubMed:20651251). Inhibited by Ba(2+) and Cs(+) (PubMed:8995301). Activated by phosphatidylinositol 4,5 biphosphate (PtdIns(4,5)P2) (By similarity). {ECO:0000250|UniProtKB:P49655, ECO:0000269|PubMed:20651251, ECO:0000269|PubMed:8995301}.
uniprot
proteins
amino_acid_sequence
MTSVAKVYYSQTTQTESRPLMGPGIRRRRVLTKDGRSNVRMEHIADKRFLYLKDLWTTFIDMQWRYKLLLFSATFAGTWFLFGVVWYLVAVAHGDLLELDPPANHTPCVVQVHTLTGAFLFSLESQTTIGYGFRYISEECPLAIVLLIAQLVLTTILEIFITGTFLAKIARPKKRAETIRFSQHAVVASHNGKPCLMIRVANMRKSLLIGCQVTGKLLQTHQTKEGENIRLNQVNVTFQVDTASDSPFLILPLTFYHVVDETSPLKDLPLRSGEGDFELVLILSGTVESTSATCQVRTSYLPEEILWGYEFTPAISLSASGKYIADFSLFDQVVKVASPSGLRDSTVRYGDPEKLKLEESLREQAEKEGSALSVRISNV
uniprot
proteins
disease_involvement
DISEASE: Seizures, sensorineural deafness, ataxia, impaired intellectual development, and electrolyte imbalance (SESAMES) [MIM:612780]: A complex disorder characterized by generalized seizures with onset in infancy, delayed psychomotor development, ataxia, sensorineural hearing loss, hypokalemia, metabolic alkalosis, and hypomagnesemia. {ECO:0000269|PubMed:19289823, ECO:0000269|PubMed:19420365, ECO:0000269|PubMed:20651251, ECO:0000269|PubMed:20807765, ECO:0000269|PubMed:21849804, ECO:0000269|PubMed:22612257, ECO:0000269|PubMed:24561201}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: May be responsible for potassium buffering action of glial cells in the brain (By similarity). Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it (PubMed:8995301). Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages (PubMed:8995301). The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (PubMed:8995301). In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules (PubMed:24561201). {ECO:0000250|UniProtKB:P49655, ECO:0000269|PubMed:8995301, ECO:0000305|PubMed:24561201}.
uniprot
proteins
mass_dalton
42508
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ10 subfamily
uniprot
proteins
pubmed
10659995
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19289823
uniprot
proteins
pubmed
19420365
uniprot
proteins
pubmed
20651251
uniprot
proteins
pubmed
20807765
uniprot
proteins
pubmed
21849804
uniprot
proteins
pubmed
22612257
uniprot
proteins
pubmed
24561201
uniprot
proteins
pubmed
28887846
uniprot
proteins
pubmed
8995301
uniprot
proteins
sequence_length
379
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:24561201}; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000269|PubMed:24561201}. Note=In kidney distal convoluted tubules, located in the basolateral membrane where it colocalizes with KCNJ16. {ECO:0000269|PubMed:24561201}.
uniprot
proteins
transmembrane_region
TRANSMEM 62..88; /note="Helical; Name=M1"; /evidence="ECO:0000250|UniProtKB:P49655"; TRANSMEM 141..166; /note="Helical; Name=M2"; /evidence="ECO:0000250|UniProtKB:P49655
uniprot
proteins