FAM120A
entrez
23196
canonical
uniprot
Q9NZB2
canonical
ensembl
ENSG00000048828
resolver
ensp
ENSP00000277165
resolver
ensp
ENSP00000364538
resolver
ensp
ENSP00000514050
resolver
ensp
ENSP00000552115
resolver
ensp
ENSP00000552116
resolver
ensp
ENSP00000589823
resolver
enst
ENST00000698944
resolver
genesymbol
FAM120A
resolver
genesymbol_syn
C9orf10
resolver
genesymbol_syn
KIAA0183
resolver
genesymbol_syn
OSSA
resolver
hgnc
HGNC:13247
resolver
uniprot
A0A8V8TNY3
resolver
uniprot
A6NGU0
resolver
uniprot
C4AMC6
resolver
uniprot
O60649
resolver
uniprot
Q14688
resolver
uniprot
Q4VXF4
resolver
uniprot
Q4VXF5
resolver
uniprot
Q4VXG2
resolver
uniprot
Q86V69
resolver
uniprot
Q96I21
resolver
uniprot
Q9NZB1
resolver
uniprot_entry
A0A8V8TNY3_HUMAN
resolver
uniprot_entry
F120A_HUMAN
resolver
uniprot_sec
A6NGU0
resolver
uniprot_sec
C4AMC6
resolver
uniprot_sec
O60649
resolver
uniprot_sec
Q14688
resolver
uniprot_sec
Q4VXF4
resolver
uniprot_sec
Q4VXF5
resolver
uniprot_sec
Q4VXG2
resolver
uniprot_sec
Q86V69
resolver
uniprot_sec
Q96I21
resolver
uniprot_sec
Q9NZB1
resolver
amino_acid_sequence
MGVQGFQDYIEKHCPSAVVPVELQKLARGSLVGGGRQRPPQTPLRLLVDADNCLHRLYGGFYTDWVSGGQWNHMLGYLAALAKACFGGNIELFVFFNGALEKARLHEWVKRQGNERQTAQQIVSHVQNKGTPPPKVWFLPPVCMAHCIRLALIRFHVKVAQSIEDHHQEVIGFCRENGFHGLVAYDSDYALCNIPYYFSAHALKLSRNGKSLTTSQYLMHEVAKQLDLNPNRFPIFAALLGNHILPDEDLASFHWSLLGPEHPLASLKVRAHQLVLPPCDVVIKAVADYVRNIQDTSDLDAIAKDVFQHSQSRTDDKVIRFKRAIGYYSATSKPMSFHPPHYLAARPGPFGMPGMVPPHVPPQMLNIPQTSLQAKPVAPQVPSPGGAPGQGPYPYSLSEPAPLTLDTSGKNLTEQNSYSNIPHEGKHTPLYERSSPINPAQSGSPNHVDSAYFPGSSTSSSSDNDEGSGGATNHISGNKIGWEKTGSHSEPQARGDPGDQTKAEGSSTASSGSQLAEGKGSQMGTVQPIPCLLSMPTRNHMDITTPPLPPVAPEVLRVAEHRHKKGLMYPYIFHVLTKGEIKIAVSIEDEANKDLPPAALLYRPVRQYVYGVLFSLAESRKKTERLAFRKNRLPPEFSPVIIKEWAAYKGKSPQTPELVEALAFREWTCPNLKRLWLGKAVEDKNRRMRAFLACMRSDTPAMLNPANVPTHLMVLCCVLRYMVQWPGARILRRQELDAFLAQALSPKLYEPDQLQELKIENLDPRGIQLSALFMSGVDMALFANDACGQPIPWEHCCPWMYFDGKLFQSKLLKASREKTPLIDLCDGQADQAAKVEKMRQSVLEGLSFSRQSHTLPFPPPPALPFYPASAYPRHFGPVPPSQGRGRGFAGVCGFGGPYGETVATGPYRAFRVAAASGHCGAFSGSDSSRTSKSQGGVQPIPSQGGKLEIAGTVVGHWAGSRRGRGGRGPFPLQVVSVGGPARGRPRGVISTPVIRTFGRGGRYYGRGYKNQAAIQGRPPYAASAEEVAKELKSKSGESKSSAMSSDGSLAENGVMAEEKPAPQMNGSTGDARAPSHSESALNNDSKTCNTNPHLNALSTDSACRREAALEAAVLNKEE
uniprot
proteins
disease_involvement
DISEASE: Note=May play a role in the progression of scirrhous-type gastric cancer by supporting cancer cell survival during oxidative stress. {ECO:0000269|PubMed:19015244}.
uniprot
proteins
function
FUNCTION: Membrane-associated scaffold protein that participates in multiple cellular processes, including oxidative stress-induced survival signaling, RNA trafficking and translational regulation, and the modulation of membrane signaling through its interaction with RNA-binding proteins and lipid raft-associated domains (PubMed:19015244). Functions as a regulator of activation of several intracellular kinases, including SRC, FAK, and PI3K, following oxidative stress (PubMed:19015244). Promotes RNA splicing and stability of lipogenic enzymes (PubMed:37595559). Mechanistically, recruits the lipogenic transcription factor SREBP1 at active promoters, thereby bridging the newly transcribed lipogenic genes from RNA polymerase II to the SRSF1 and U1-70K-containing RNA-splicing machinery (PubMed:37595559). Associates with key proteins of the NLRP3 inflammasome pathway and subsequently inhibits NLRP3 inflammasome activation (PubMed:40250624). Sequesters a subset of AGO2-bound mRNAs from miRNA-mediated silencing by binding to poly(G)-rich motifs in their 3'-UTR independently of the AGO2 binding site, likely by preventing recruitment of miRISC effectors (By similarity). {ECO:0000250|UniProtKB:Q6A0A9, ECO:0000269|PubMed:19015244, ECO:0000269|PubMed:37595559, ECO:0000269|PubMed:40250624}.
uniprot
proteins
mass_dalton
121888
uniprot
proteins
post_translational_modification
PTM: Arg-982 is dimethylated, probably to asymmetric dimethylarginine. {ECO:0000269|PubMed:24129315}.; PTM: Phosphorylated on tyrosine by SRC family protein kinases upon oxidative stress, for instance following UV irradiation. {ECO:0000269|PubMed:19015244}.
uniprot
proteins
protein_family
Constitutive coactivator of PPAR-gamma family
uniprot
proteins
pubmed
14585507
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19015244
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
37595559
uniprot
proteins
pubmed
40250624
uniprot
proteins
pubmed
8724849
uniprot
proteins
sequence_length
1118
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19015244}. Cell membrane {ECO:0000269|PubMed:19015244}; Peripheral membrane protein {ECO:0000305|PubMed:19015244}; Cytoplasmic side {ECO:0000305|PubMed:19015244}. Note=Translocates from the cytosol to plasma membrane after UV irradiation. {ECO:0000269|PubMed:19015244}.
uniprot
proteins