Slc40a1
entrez
170840
canonical
uniprot
Q923U9
canonical
ensembl
ENSRNOG00000003872
resolver
ensembl
ENSRNOG00055004811
resolver
ensembl
ENSRNOG00060016832
resolver
ensembl
ENSRNOG00065030099
resolver
ensp
ENSRNOP00000005228
resolver
ensp
ENSRNOP00055005787
resolver
ensp
ENSRNOP00060023164
resolver
ensp
ENSRNOP00065042776
resolver
enst
ENSRNOT00000005228
resolver
enst
ENSRNOT00055007668
resolver
enst
ENSRNOT00060028791
resolver
enst
ENSRNOT00065051968
resolver
genesymbol
Slc40a1
resolver
genesymbol_syn
Fpn1
resolver
genesymbol_syn
Fpt1
resolver
uniprot
G3V6H7
resolver
uniprot
Q9Z1C9
resolver
uniprot_entry
S40A1_RAT
resolver
uniprot_sec
G3V6H7
resolver
uniprot_sec
Q9Z1C9
resolver
activity_regulation
ACTIVITY REGULATION: During elevated serum iron levels, liver-derived hepcidin/HAMP negatively regulates cell surface SLC40A1 by inducing its ubiquitination, internalization, and degradation. Indeed, hepcidin/HAMP affinity towards ferroportin/SLC40A1 increases by 80-fold in the presence of iron. {ECO:0000250|UniProtKB:Q9NP59}.
uniprot
proteins
amino_acid_sequence
MTKSRDQTHQEGCCGSLANYLTSAKFLLYLGHSLSTWGDRMWHFAVSVFLVELYGNSLLLTAVYGLVVAGSVLVLGAIIGDWVDKNARLKVAQTSLVVQNVSVILCGIILMMVFLHKNELLNMYHGWVLTVCYILIITIANIANLASTATAITIQRDWIVVVAGENRSRLADMNATIRRIDQLTNILAPMAVGQIMTFGSPVIGCGFISGWNLVSMCVEYFLLWKVYQKTPALAVKAALKVEESELKQLTSPKDTEPKPLEGTHLMGEKDSNIRELECEQEPTCASQIAEPFRTFRDGWVSYYNQPVFLAGMGLAFLYMTVLGFDCITTGYAYTQGLSGSILSVLMGASAITGIMGTVAFTWLRRKCGLVRTGLFSGLAQLSCLILCVISVFMPGSPLDLSVSPFEDIRSRFIHEEAVSSTTKIPETEMLMSNVSNVVNTVHEMSTKSVPIISVSLLFAGVIAARIGLWSFDLTVTQLLQENVIESERGIINGVQNSMNYLLDLLHFIMVILAPNPEAFGLLVLISVSFVAMGHLMYFRFAQKTLGNQIFVCAPDEKEVTDESQPNTSVV
uniprot
proteins
function
FUNCTION: Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis (By similarity). Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues. Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes (By similarity). When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma (By similarity). {ECO:0000250|UniProtKB:Q9JHI9, ECO:0000250|UniProtKB:Q9NP59}.
uniprot
proteins
mass_dalton
62616
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated by RNF217; leading to proteasomal degradation (By similarity). Under conditions of high systemic iron levels, both the hormone peptide hepcidin/HAMP and holo(iron bound)-transferrin/TF induce the ubiquitination, internalization and proteasomal degradation of SLC40A1 to control iron release from cells (By similarity). {ECO:0000250|UniProtKB:Q9JHI9, ECO:0000250|UniProtKB:Q9NP59}.
uniprot
proteins
protein_family
Ferroportin (FP) (TC 2.A.100) family
uniprot
proteins
protein_family
SLC40A subfamily
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
570
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9NP59}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NP59}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q9NP59}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NP59}. Note=Localized to the basolateral membrane of polarized epithelial cells. {ECO:0000250|UniProtKB:Q9NP59}.
uniprot
proteins
transmembrane_region
TRANSMEM 24..53; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NP59"; TRANSMEM 58..84; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NP59"; TRANSMEM 88..118; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NP59"; TRANSMEM 127..162; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NP59"; TRANSMEM 165..195; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NP59"; TRANSMEM 203..229; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NP59"; TRANSMEM 307..333; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NP59"; TRANSMEM 339..366; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NP59"; TRANSMEM 369..391; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NP59"; TRANSMEM 453..482; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NP59"; TRANSMEM 488..512; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NP59"; TRANSMEM 516..541; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NP59
uniprot
proteins