CIRSR
entrez
9541
canonical
uniprot
Q86X95
canonical
ensembl
ENSG00000138433
resolver
ensp
ENSP00000339723
resolver
genesymbol
CIRSR
resolver
genesymbol_syn
CIR
resolver
genesymbol_syn
CIR1
resolver
hgnc
HGNC:24217
resolver
uniprot
A6NFI6
resolver
uniprot
A8K8M4
resolver
uniprot
O95367
resolver
uniprot
Q12804
resolver
uniprot
Q4G1B9
resolver
uniprot
Q6PJI4
resolver
uniprot
Q8IWI2
resolver
uniprot_entry
CIR1_HUMAN
resolver
uniprot_sec
A6NFI6
resolver
uniprot_sec
A8K8M4
resolver
uniprot_sec
O95367
resolver
uniprot_sec
Q12804
resolver
uniprot_sec
Q4G1B9
resolver
uniprot_sec
Q6PJI4
resolver
uniprot_sec
Q8IWI2
resolver
amino_acid_sequence
MGKSFANFMCKKDFHPASKSNIKKVWMAEQKISYDKKKQEELMQQYLKEQESYDNRLLMGDERVKNGLNFMYEAPPGAKKENKEKEETEGETEYKFEWQKGAPREKYAKDDMNIRDQPFGIQVRNVRCIKCHKWGHVNTDRECPLFGLSGINASSVPTDGSGPSMHPSELIAEMRNSGFALKRNVLGRNLTANDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRSHGTDLYRGEKMYREHPGGTHTKVTQRE
uniprot
proteins
function
FUNCTION: May modulate splice site selection during alternative splicing of pre-mRNAs (By similarity). Regulates transcription and acts as corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription. {ECO:0000250, ECO:0000269|PubMed:19409814, ECO:0000269|PubMed:9874765}.
uniprot
proteins
mass_dalton
52313
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by NEK6. {ECO:0000269|PubMed:20873783}.
uniprot
proteins
pubmed
10644367
uniprot
proteins
pubmed
11222720
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19409814
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20873783
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
9874765
uniprot
proteins
sequence_length
450
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q9DA19}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20873783}. Note=Colocalizes with NEK6 in the centrosome. {ECO:0000269|PubMed:20873783}.
uniprot
proteins