Gas2
entrez
14453
canonical
uniprot
P11862
canonical
ensembl
ENSMUSG00000030498
resolver
ensp
ENSMUSP00000053514
resolver
ensp
ENSMUSP00000103217
resolver
ensp
ENSMUSP00000146537
resolver
ensp
ENSMUSP00000290469
resolver
ensp
ENSMUSP00000290470
resolver
ensp
ENSMUSP00000290471
resolver
ensp
ENSMUSP00000290473
resolver
ensp
ENSMUSP00000290476
resolver
ensp
ENSMUSP00000290477
resolver
enst
ENSMUST00000051912
resolver
enst
ENSMUST00000107591
resolver
enst
ENSMUST00000208711
resolver
genesymbol
Gas2
resolver
genesymbol_syn
Gas-2
resolver
uniprot
Q9D699
resolver
uniprot_entry
GAS2_MOUSE
resolver
uniprot_entry
Q9D699_MOUSE
resolver
amino_acid_sequence
MMCTALSPKVRSGPGLSDMHQYSQWLASRHEANLLPMKEDLALWLTNLLGKEITAETFMEKLDNGALLCQLAATVQEKFKESMDANKPAKTLPLKKIPCKASAPSGSFFARDNTANFLSWCRDLGVDETCLFESEGLVLHKQPREVCLCLLELGRIAARYGVEPPGLIKLEKEIEQEETLSAPSPSPSPSSKSSGKKSTGNLLDDAVKRISEDPPCKCPTKFCVERLSQGRYRVGEKILFIRMLHNKHVMVRVGGGWETFAGYLLKHDPCRMLQISRVDGKTSPVQSKSPTLKDMNPDNYLVVSATYKAKKEIK
uniprot
proteins
function
FUNCTION: Required to maintain microtubule bundles in inner ear supporting cells, affording them with mechanical stiffness to transmit sound energy through the cochlea. {ECO:0000269|PubMed:33964205}.
uniprot
proteins
mass_dalton
34901
uniprot
proteins
mutagenesis
MUTAGEN 279; /note="D->A: Abolishes proteolytic processing."; /evidence="ECO:0000269|PubMed:7489707
uniprot
proteins
post_translational_modification
PTM: Cleaved, during apoptosis, on a specific aspartic residue by caspases. {ECO:0000250}.; PTM: Phosphorylated on serine residues during the G0-G1 transition phase. {ECO:0000269|PubMed:8120096}.
uniprot
proteins
protein_family
GAS2 family
uniprot
proteins
pubmed
10049561
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1607387
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
33964205
uniprot
proteins
pubmed
3409319
uniprot
proteins
pubmed
7489707
uniprot
proteins
pubmed
8120096
uniprot
proteins
sequence_length
314
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:8120096}. Membrane {ECO:0000269|PubMed:8120096}; Peripheral membrane protein {ECO:0000269|PubMed:8120096}. Note=Component of the microfilament system (PubMed:1607387). Colocalizes with actin fibers at the cell border and along the stress fibers in growth-arrested fibroblasts (PubMed:8120096). Mainly membrane-associated (PubMed:8120096). When hyperphosphorylated, accumulates at membrane ruffles (PubMed:8120096). Colocalizes with detyrosinated alpha-tubulin along the length of microtubule bundles in inner and outer pillar cells (PubMed:33964205). {ECO:0000269|PubMed:1607387, ECO:0000269|PubMed:33964205, ECO:0000269|PubMed:8120096}.
uniprot
proteins