Myo18a
entrez
360013
canonical
uniprot
Q9JMH9
canonical
ensembl
ENSMUSG00000000631
resolver
ensp
ENSMUSP00000090563
resolver
ensp
ENSMUSP00000098358
resolver
ensp
ENSMUSP00000104012
resolver
ensp
ENSMUSP00000129098
resolver
ensp
ENSMUSP00000130696
resolver
ensp
ENSMUSP00000132149
resolver
ensp
ENSMUSP00000161461
resolver
ensp
ENSMUSP00000161463
resolver
ensp
ENSMUSP00000161465
resolver
ensp
ENSMUSP00000161468
resolver
ensp
ENSMUSP00000161472
resolver
enst
ENSMUST00000100794
resolver
enst
ENSMUST00000168348
resolver
enst
ENSMUST00000169105
resolver
enst
ENSMUST00000172303
resolver
genesymbol
Myo18a
resolver
genesymbol_syn
Myspdz
resolver
uniprot
A0A1C7ZN10
resolver
uniprot
A0A4Y5WWJ7
resolver
uniprot
B2RRE2
resolver
uniprot
E9Q405
resolver
uniprot
E9QAX2
resolver
uniprot
F6X1D4
resolver
uniprot
Q3TBB2
resolver
uniprot
Q3UH48
resolver
uniprot
Q3UIM4
resolver
uniprot
Q3UV60
resolver
uniprot
Q5QD54
resolver
uniprot
Q5QD55
resolver
uniprot
Q5QD56
resolver
uniprot
Q5SYN8
resolver
uniprot
Q5SYN9
resolver
uniprot
Q5SYP0
resolver
uniprot
Q5SYP1
resolver
uniprot
Q811D7
resolver
uniprot_entry
A0A1C7ZN10_MOUSE
resolver
uniprot_entry
A0A4Y5WWJ7_MOUSE
resolver
uniprot_entry
B2RRE2_MOUSE
resolver
uniprot_entry
E9Q405_MOUSE
resolver
uniprot_entry
E9QAX2_MOUSE
resolver
uniprot_entry
F6X1D4_MOUSE
resolver
uniprot_entry
MY18A_MOUSE
resolver
uniprot_entry
Q3UIM4_MOUSE
resolver
uniprot_sec
Q3TBB2
resolver
uniprot_sec
Q3UH48
resolver
uniprot_sec
Q3UV60
resolver
uniprot_sec
Q5QD54
resolver
uniprot_sec
Q5QD55
resolver
uniprot_sec
Q5QD56
resolver
uniprot_sec
Q5SYN8
resolver
uniprot_sec
Q5SYN9
resolver
uniprot_sec
Q5SYP0
resolver
uniprot_sec
Q5SYP1
resolver
uniprot_sec
Q811D7
resolver
amino_acid_sequence
MFNLMKKDKDKDGGRKEKKEKKEKKERMSAAELRSLEEMSMRRGFFNLNRSSKRESKTRLEISNPIPIKVASGSDLHLTDIDSDSNRGSIILDSGHLSTASSSDDLKGEEGSFRGSVLQRAAKFGSLAKQNSQMIVKRFSFSQRSRDESASETSTPSEHSAAPSPQVEVRTLEGQLMQHPGLGIPRPGPRSRVPELVTKRFPADLRLPALVPPPPPALRELELQRRPTGDFGFSLRRTTMLDRAPEGQAYRRVVHFAEPGAGTKDLALGLVPGDRLVEINGQNVENKSRDEIVEMIRQSGDSVRLKVQPIPELSELSRSWLRTGEGHRREPADAKTEEQIAAEEAWYETEKVWLVHRDGFSLASQLKSEELSLPEGKARVKLDHDGAILDVDEDDIEKANAPSCDRLEDLASLVYLNESSVLHTLRQRYGASLLHTYAGPSLLVLSTRGAPAVYSEKVMHMFKGCRREDMAPHIYAVAQTAYRAMLMSRQDQSIVLLGSSGSGKTTSFQHLVQYLATIAGTSGTKVFSVEKWQALSTLLEAFGNSPTIMNGSATRFSQILSLDFDQAGQVASASIQTMLLEKLRVARRPASEATFNVFYYLLACGDATLRTELHLNHLAENNVFGIVPLSKPEEKQKAAQQFSKLQAAMKVLAISPEEQKTCWLILASIYHLGAAGATKEAAEAGRKQFARHEWAQKAAYLLGCSLEELSSAIFKHQLKGGTLQRSTSFRQGPEESGLGEGTKLSALECLEGMASGLYSELFTLLISLVNRALKSSQHSLCSMMIVDTPGFQNPEWGGSARGASFEELCHNYAQDRLQRLFHERTFLQELERYKEDNIELAFDDLEPVADDSVAAVDQASHLVRSLAHADEARGLLWLLEEEALVPGATEDALLDRLFSYYGPQEGDKKGQSPLLRSSKPRHFLLGHSHGTNWVEYNVAGWLNYTKQNPATQNAPRLLQDSQKKIISNLFLGRAGSATVLSGSIAGLEGGSQLALRRATSMRKTFTTGMAAVKKKSLCIQIKLQVDALIDTIKRSKMHFVHCFLPVAEGWPGEPRSASSRRVSSSSELDLPPGDPCEAGLLQLDVSLLRAQLRGSRLLDAMRMYRQGYPDHMVFSEFRRRFDVLAPHLTKKHGRNYIVVDEKRAVEELLESLDLEKSSCCLGLSRVFFRAGTLARLEEQRDEQTSRHLTLFQAACRGYLARQHFKKRKIQDLAIRCVQKNIKKNKGVKDWPWWKLFTTVRPLIQVQLSEEQIRNKDEEIQQLRSKLEKVEKERNELRLSSDRLETRISELTSELTDERNTGESASQLLDAETAERLRTEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQELEDKMEVEQQSRRQLERRLGDLQADSDESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEETQREKLQREKLQREKDMLLAEAFSLKQQMEEKDLDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGSIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKALREKRELESKLSTLSDQVNQRDFESEKRLRKDLKRTKALLADAQIMLDHLKNNAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEMEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDMAQMNDLQAQIEESNKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFEKTQVKRLENLASRLKETMEKLTEERDQRAAAENREKEQNKRLQRQLRDTKEEMSELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMESDENEDLINSLQDMVTKYQKKKNKLEGDSDVDSELEDRVDGVKSWLSKNKGPSKAPSDDGSLKSSSPTSHWKPLAPDPSDDEHDPVDSISRPRFSHSYLSDSDTEAKLTETSA
uniprot
proteins
function
FUNCTION: May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (By similarity). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (PubMed:10733906). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (By similarity). {ECO:0000250|UniProtKB:Q92614, ECO:0000269|PubMed:10733906, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:25965346}.
uniprot
proteins
mass_dalton
232755
uniprot
proteins
mutagenesis
MUTAGEN 503..504; /note="GK->SA: Loss of function."; /evidence="ECO:0000269|PubMed:19837035
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine upon CSF1R activation. Isoform 6 is phosphorylated on Ser-340. {ECO:0000269|PubMed:14969583}.
uniprot
proteins
protein_family
Myosin family
uniprot
proteins
protein_family
TRAFAC class myosin-kinesin ATPase superfamily
uniprot
proteins
pubmed
10733906
uniprot
proteins
pubmed
10733938
uniprot
proteins
pubmed
12761286
uniprot
proteins
pubmed
14969583
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15582604
uniprot
proteins
pubmed
16087679
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19837035
uniprot
proteins
pubmed
21123169
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25965346
uniprot
proteins
sequence_length
2050
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250|UniProtKB:Q92614}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q92614}. Golgi outpost {ECO:0000250|UniProtKB:D3ZFD0}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000250|UniProtKB:D3ZFD0}. Note=Recruited to the Golgi apparatus by GOLPH3 (By similarity). Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation (By similarity). {ECO:0000250|UniProtKB:D3ZFD0, ECO:0000250|UniProtKB:Q92614}.; SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:12761286}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12761286}. Note=Colocalizes with actin. {ECO:0000269|PubMed:12761286}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:12761286}. Note=Lacks the PDZ domain. Diffusely localized in the cytoplasm. {ECO:0000269|PubMed:12761286}.
uniprot
proteins