Gk2
entrez
14626
canonical
uniprot
Q9WU65
canonical
ensembl
ENSMUSG00000050553
resolver
ensp
ENSMUSP00000052226
resolver
enst
ENSMUST00000059657
resolver
genesymbol
Gk2
resolver
genesymbol_syn
Gk-rs2
resolver
genesymbol_syn
Gkrs2
resolver
uniprot_entry
GLPK2_MOUSE
resolver
amino_acid_sequence
MAASKQTSAGPLVGAVVQGTNSTRFLVFNSKTAELVCSHQVELTQEYPKEGWVEQDPKEILKSVYECIAKACEKLAEVNIDISNIKAIGVSNQRETTVVWDKFTGDPLYNAVVWLDLRTQSTVETLTKKIPGNSNFVKSKTGLPLSTYFSAVKLRWMLDNLRPIQKAVEEGRAMFGTIDSWLIWCMTGGVNGGIHCTDVTNACRTMLFNIHSLEWDKDLCDFFEIPMSILPNVCSSSEIYGLMTSGALEGVPISGCLGDQSAALVGQMCFHEGQAKNTYGTGCFLLCNTGQKCVFSEHGLLTTLAYKLGKNKPVFYALEGSVAIAGAVIRWLRDNFEIITTSGEVENLAREVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTNNRILMQLQADILHIPVVKSVMPETTALGAAMAAGAAEGVNVWSLEPEDLSTILMERYEPQIQATESEIRFSTWKRAVMKSMGWVTAKDPENGDNPVFSCLPLGFFIVSSMTLLIGARCVSTAEE
uniprot
proteins
ec_number
2.7.1.30
uniprot
proteins
function
FUNCTION: Key enzyme in the regulation of glycerol uptake and metabolism. Essential for male fertility and sperm mitochondrial sheath formation (PubMed:28852571, PubMed:30662012). Required for proper arrangement of crescent-like mitochondria to form the mitochondrial sheath during spermatogenesis (PubMed:30662012). Can induce mitochondrial clustering through interactions with PLD6 and up-regulation of phosphatidic acid synthesis in the mitochondria (PubMed:28852571). {ECO:0000269|PubMed:28852571, ECO:0000269|PubMed:30662012}.
uniprot
proteins
mass_dalton
60630
uniprot
proteins
pathway_participation
PATHWAY: Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
uniprot
proteins
protein_family
FGGY kinase family
uniprot
proteins
pubmed
10444329
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28852571
uniprot
proteins
pubmed
30662012
uniprot
proteins
pubmed
33536340
uniprot
proteins
sequence_length
554
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:28852571}; Single-pass type IV membrane protein {ECO:0000305|PubMed:28852571}. Cytoplasm {ECO:0000250}. Note=In sperm the majority of the enzyme is bound to mitochondria. {ECO:0000269|PubMed:28852571}.
uniprot
proteins
transmembrane_region
TRANSMEM 526..546; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins