Gstp1
entrez
14870
canonical
uniprot
P19157
canonical
ensembl
ENSMUSG00000060803
resolver
ensp
ENSMUSP00000129565
resolver
enst
ENSMUST00000169613
resolver
genesymbol
Gstp1
resolver
genesymbol_syn
Gstpib
resolver
uniprot
Q8BNY4
resolver
uniprot_entry
GSTP1_MOUSE
resolver
uniprot_sec
Q8BNY4
resolver
amino_acid_sequence
MPPYTIVYFPVRGRCEAMRMLLADQGQSWKEEVVTIDTWMQGLLKPTCLYGQLPKFEDGDLTLYQSNAILRHLGRSLGLYGKNQREAAQMDMVNDGVEDLRGKYVTLIYTNYENGKNDYVKALPGHLKPFETLLSQNQGGKAFIVGDQISFADYNLLDLLLIHQVLAPGCLDNFPLLSAYVARLSARPKIKAFLSSPEHVNRPINGNGKQ
uniprot
proteins
ec_number
2.5.1.18
uniprot
proteins
function
FUNCTION: Catalyzes conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). Participates in the formation of novel hepoxilin regioisomers. Acts as a negative regulator of ferroptosis by mediating glutathione conjugation and detoxification of 4-hydroxynonenal (4-HNE) reactive aldehyde. Negatively regulates CDK5 activity via p25/p35 translocation to prevent neurodegeneration. {ECO:0000250|UniProtKB:P09211}.
uniprot
proteins
mass_dalton
23609
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by SMURF2, leading to its degradation and initiation of ferroptosis. {ECO:0000250|UniProtKB:P09211}.
uniprot
proteins
protein_family
GST superfamily
uniprot
proteins
protein_family
Pi family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
2388840
uniprot
proteins
pubmed
7982937
uniprot
proteins
pubmed
8135745
uniprot
proteins
pubmed
8145243
uniprot
proteins
pubmed
8605288
uniprot
proteins
pubmed
9446594
uniprot
proteins
sequence_length
210
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P09211}. Mitochondrion {ECO:0000250|UniProtKB:P09211}. Nucleus {ECO:0000250|UniProtKB:P09211}. Note=The 83 N-terminal amino acids function as un uncleaved transit peptide, and arginine residues within it are crucial for mitochondrial localization. {ECO:0000250|UniProtKB:P09211}.
uniprot
proteins