Hes1
entrez
29577
canonical
uniprot
Q04666
canonical
ensembl
ENSRNOG00000001720
resolver
ensembl
ENSRNOG00055016255
resolver
ensembl
ENSRNOG00060019897
resolver
ensembl
ENSRNOG00065017613
resolver
ensp
ENSRNOP00000002346
resolver
ensp
ENSRNOP00055022133
resolver
ensp
ENSRNOP00060028236
resolver
ensp
ENSRNOP00065023398
resolver
enst
ENSRNOT00000002346
resolver
enst
ENSRNOT00055027579
resolver
enst
ENSRNOT00060034405
resolver
enst
ENSRNOT00065029477
resolver
genesymbol
Hes1
resolver
genesymbol_syn
Hes-1
resolver
genesymbol_syn
Hl
resolver
uniprot_entry
HES1_RAT
resolver
amino_acid_sequence
MPADIMEKNSSSPVAATPASVNTTPDKPKTASEHRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTVKHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTEVRTRLLGHLANCMTQINAMTYPGQAHPALQAPPPPPPSGPGGPQHAPFAPPPPLVPIPGGAAPPPGSAPCKLGSQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTSVGPNAVSPSSGSSLTADSMWRPWRN
uniprot
proteins
function
FUNCTION: Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity). {ECO:0000250, ECO:0000269|PubMed:8649374}.
uniprot
proteins
mass_dalton
29622
uniprot
proteins
pubmed
1340473
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8417318
uniprot
proteins
pubmed
8649374
uniprot
proteins
pubmed
8687460
uniprot
proteins
sequence_length
281
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins