Polr2g
entrez
117017
canonical
uniprot
P62489
canonical
ensembl
ENSRNOG00000019439
resolver
ensembl
ENSRNOG00055017632
resolver
ensembl
ENSRNOG00060033195
resolver
ensembl
ENSRNOG00065033389
resolver
ensp
ENSRNOP00000026313
resolver
ensp
ENSRNOP00055023972
resolver
ensp
ENSRNOP00060047515
resolver
ensp
ENSRNOP00065047247
resolver
enst
ENSRNOT00000026313
resolver
enst
ENSRNOT00055029840
resolver
enst
ENSRNOT00060057553
resolver
enst
ENSRNOT00065057406
resolver
genesymbol
Polr2g
resolver
uniprot
P52433
resolver
uniprot_entry
RPB7_RAT
resolver
uniprot_sec
P52433
resolver
amino_acid_sequence
MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQPGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFDPNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS
uniprot
proteins
function
FUNCTION: Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. POLR2G/RPB7 is part of a subcomplex with POLR2D/RPB4 that binds to a pocket formed by POLR2A/RPB1, POLR2B/RPB2 and POLR2F/RPABC2 at the base of the clamp element. The POLR2D/RPB4-POLR2G/RPB7 subcomplex seems to lock the clamp via POLR2G/RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The POLR2D/RPB4-POLR2G/RPB7 subcomplex binds single-stranded DNA and RNA. {ECO:0000250|UniProtKB:P34087, ECO:0000250|UniProtKB:P62487}.
uniprot
proteins
mass_dalton
19294
uniprot
proteins
protein_family
Eukaryotic RPB7/RPC8 RNA polymerase subunit family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
172
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P62487}.
uniprot
proteins