CBWD5
entrez
220869
canonical
uniprot
Q5RIA9
canonical
ensembl
ENSG00000147996
resolver
ensembl
ENSG00000196873
resolver
ensp
ENSP00000366601
resolver
ensp
ENSP00000366609
resolver
ensp
ENSP00000366612
resolver
ensp
ENSP00000371842
resolver
ensp
ENSP00000397999
resolver
ensp
ENSP00000405076
resolver
ensp
ENSP00000419839
resolver
ensp
ENSP00000420033
resolver
ensp
ENSP00000475010
resolver
ensp
ENSP00000527388
resolver
ensp
ENSP00000653339
resolver
ensp
ENSP00000720770
resolver
ensp
ENSP00000767697
resolver
ensp
ENSP00000767698
resolver
ensp
ENSP00000767699
resolver
ensp
ENSP00000767703
resolver
enst
ENST00000377384
resolver
enst
ENST00000377392
resolver
enst
ENST00000430059
resolver
enst
ENST00000476161
resolver
enst
ENST00000478048
resolver
enst
ENST00000497250
resolver
genesymbol
CBWD5
resolver
genesymbol
ZNG1C
resolver
genesymbol
ZNG1E
resolver
genesymbol_syn
CBWD5
resolver
genesymbol_syn
ZNG1E
resolver
hgnc
HGNC:18519
resolver
hgnc
HGNC:24584
resolver
uniprot
F6QX95
resolver
uniprot
O60748
resolver
uniprot
Q5RIB0
resolver
uniprot
Q5RIB3
resolver
uniprot
Q5RIB5
resolver
uniprot
Q6NVZ8
resolver
uniprot
Q8N7U8
resolver
uniprot
Q9H2J8
resolver
uniprot
S4R432
resolver
uniprot_entry
F6QX95_HUMAN
resolver
uniprot_entry
O60748_HUMAN
resolver
uniprot_entry
Q5RIB0_HUMAN
resolver
uniprot_entry
Q5RIB3_HUMAN
resolver
uniprot_entry
Q5RIB5_HUMAN
resolver
uniprot_entry
Q6NVZ8_HUMAN
resolver
uniprot_entry
Q9H2J8_HUMAN
resolver
uniprot_entry
ZNG1E_HUMAN
resolver
uniprot_sec
Q8N7U8
resolver
uniprot_sec
S4R432
resolver
amino_acid_sequence
MLPAVGSVDEEEDPAEEDCPELVPIETTQSEEEEKSGLGAKIPVTIITGYLGAGKTTLLNYILTEQHSKRVAVILNESGEGSALEKSLAVSQGGELYEEWLELRNGCLCCSVKDNGLRAIENLMQKKGKFDDILLETTGLADPGAVTSMFWVDAELGSDIYLDGIITIVDSKYGLKHLTEEKPDGLINEATRQVALADIILINKTDLVPEEDVKKLRTTIRSINGLGQILETQRSRVDLSNVLDLHAFDSLSGISLQKKLQHVPGTQPHLDQSIVTITFEVPGNAKEEHLNMFIQNLLWEKNVRNKDNHCMEVIRLKGLVSIKDKSQQVIVQGVHELYDLEETPVSWKDDTERTNRLVLIGRNLDKDILKQLFIATVTETEKQWTTHFKEDQVCT
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Zinc chaperone that directly transfers zinc cofactor to target metalloproteins, thereby activating them. Catalyzes zinc insertion into the active site of methionine aminopeptidase METAP1, which function to cleave the initiator methionine from polypeptides during or after protein translation. Mechanistically, the N-terminal psi-PxLVp motif binds to the C6H2-type zinc finger of inactive form of METAP1. After formation of the docked complex, zinc is transferred from the CXCC motif in the GTPase domain of ZNG1E to the zinc binding site in the peptidase domain of METAP1 in a process requiring GTP hydrolysis. GTP/GDP exchange is required for release of active METAP1. {ECO:0000250|UniProtKB:Q8VEH6}.
uniprot
proteins
mass_dalton
44068
uniprot
proteins
protein_family
SIMIBI class G3E GTPase family
uniprot
proteins
protein_family
ZNG1 subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
35584702
uniprot
proteins
sequence_length
395
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8VEH6}.
uniprot
proteins