Dcx
entrez
13193
canonical
uniprot
O88809
canonical
ensembl
ENSMUSG00000031285
resolver
ensp
ENSMUSP00000033642
resolver
ensp
ENSMUSP00000084570
resolver
ensp
ENSMUSP00000108472
resolver
ensp
ENSMUSP00000108477
resolver
ensp
ENSMUSP00000239834
resolver
ensp
ENSMUSP00000239835
resolver
ensp
ENSMUSP00000239836
resolver
enst
ENSMUST00000033642
resolver
enst
ENSMUST00000087313
resolver
enst
ENSMUST00000112851
resolver
enst
ENSMUST00000112856
resolver
genesymbol
Dcx
resolver
genesymbol_syn
Dcn
resolver
uniprot
F7BXD4
resolver
uniprot
F7BXF5
resolver
uniprot
Q6E5A4
resolver
uniprot
Q6PGI2
resolver
uniprot
Q9CXL6
resolver
uniprot_entry
DCX_MOUSE
resolver
uniprot_entry
F7BXD4_MOUSE
resolver
uniprot_entry
F7BXF5_MOUSE
resolver
uniprot_entry
Q6PGI2_MOUSE
resolver
uniprot_entry
Q9CXL6_MOUSE
resolver
uniprot_sec
Q6E5A4
resolver
amino_acid_sequence
MELDFGHFDERDKASRNMRGSRMNGLPSPTHSAHCSFYRTRTLQALSNEKKAKKVRFYRNGDRYFKGIVYAVSSDRFRSFDALLADLTRSLSDNINLPQGVRYIYTIDGSRKIGSMDELEEGESYVCSSDNFFKKVEYTKNVNPNWSVNVKTSANMKAPQSLASSNSAQARENKDFVRPKLVTIIRSGVKPRKAVRVLLNKKTAHSFEQVLTDITEAIKLETGVVKKLYTLDGKQVTCLHDFFGDDDVFIACGPEKFRYAQDDFSLDENECRVMKGNPSAAAGPKASPTPQKTSAKSPGPMRRSKSPADSGNDQDANGTSSSQLSTPKSKQSPISTPTSPGSLRKHKVDLYLPLSLDDSDSLGDSM
uniprot
proteins
function
FUNCTION: Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May participate along with PAFAH1B1/LIS-1 in a distinct overlapping signaling pathway that promotes neuronal migration. {ECO:0000250|UniProtKB:Q9ESI7}.
uniprot
proteins
mass_dalton
40613
uniprot
proteins
mutagenesis
MUTAGEN 28; /note="S->A: Reduces overall phosphorylation by 25%."; /evidence="ECO:0000269|PubMed:15099191"; MUTAGEN 287; /note="S->A: No effect on overall phosphorylation."; /evidence="ECO:0000269|PubMed:15099191"; MUTAGEN 289; /note="T->A: No effect on overall phosphorylation."; /evidence="ECO:0000269|PubMed:15099191"; MUTAGEN 297; /note="S->A: No effect on overall phosphorylation."; /evidence="ECO:0000269|PubMed:15099191"; MUTAGEN 326; /note="T->A: No effect on overall phosphorylation."; /evidence="ECO:0000269|PubMed:15099191"; MUTAGEN 332; /note="S->A: No effect on overall phosphorylation. Reduces overall phosphorylation by 36%; when associated with A-339."; /evidence="ECO:0000269|PubMed:15099191"; MUTAGEN 336; /note="T->A: No effect on overall phosphorylation."; /evidence="ECO:0000269|PubMed:15099191"; MUTAGEN 339; /note="S->A: No effect on overall phosphorylation. Reduces overall phosphorylation by 36%; when associated with A-332."; /evidence="ECO:0000269|PubMed:15099191
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by MARK1, MARK2 and PKA regulates its ability to bind microtubules (By similarity). Phosphorylation at Ser-265 and Ser-297 seems to occur only in neonatal brain, the levels falling precipitously by postnatal day 21 (PubMed:15099191, PubMed:22807455). {ECO:0000250|UniProtKB:Q9ESI7, ECO:0000269|PubMed:15099191, ECO:0000269|PubMed:22807455}.; PTM: Ubiquitinated by MDM2, leading to its degradation by the proteasome (PubMed:25088421). Ubiquitinated by MDM2 and subsequent degradation leads to reduce the dendritic spine density of olfactory bulb granule cells (PubMed:25088421). {ECO:0000269|PubMed:25088421}.
uniprot
proteins
pubmed
15099191
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22807455
uniprot
proteins
pubmed
25088421
uniprot
proteins
pubmed
9668176
uniprot
proteins
pubmed
9837748
uniprot
proteins
sequence_length
366
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q9ESI7}. Note=Localizes at neurite tips. {ECO:0000250|UniProtKB:Q9ESI7}.
uniprot
proteins