LGALS8
entrez
3964
canonical
uniprot
O00214
canonical
ensembl
ENSG00000116977
resolver
ensp
ENSP00000309576
resolver
ensp
ENSP00000342139
resolver
ensp
ENSP00000355543
resolver
ensp
ENSP00000408657
resolver
ensp
ENSP00000435460
resolver
genesymbol
LGALS8
resolver
hgnc
HGNC:6569
resolver
uniprot
O15215
resolver
uniprot
Q5T3P5
resolver
uniprot
Q5T3Q4
resolver
uniprot
Q8TEV1
resolver
uniprot
Q96B92
resolver
uniprot
Q9BXC8
resolver
uniprot
Q9H584
resolver
uniprot
Q9H585
resolver
uniprot
Q9UEZ6
resolver
uniprot
Q9UP32
resolver
uniprot
Q9UP33
resolver
uniprot
Q9UP34
resolver
uniprot_entry
LEG8_HUMAN
resolver
uniprot_sec
O15215
resolver
uniprot_sec
Q5T3P5
resolver
uniprot_sec
Q5T3Q4
resolver
uniprot_sec
Q8TEV1
resolver
uniprot_sec
Q96B92
resolver
uniprot_sec
Q9BXC8
resolver
uniprot_sec
Q9H584
resolver
uniprot_sec
Q9H585
resolver
uniprot_sec
Q9UEZ6
resolver
uniprot_sec
Q9UP32
resolver
uniprot_sec
Q9UP33
resolver
uniprot_sec
Q9UP34
resolver
amino_acid_sequence
MMLSLNNLQNIIYNPVIPFVGTIPDQLDPGTLIVIRGHVPSDADRFQVDLQNGSSMKPRADVAFHFNPRFKRAGCIVCNTLINEKWGREEITYDTPFKREKSFEIVIMVLKDKFQVAVNGKHTLLYGHRIGPEKIDTLGIYGKVNIHSIGFSFSSDLQSTQASSLELTEISRENVPKSGTPQLRLPFAARLNTPMGPGRTVVVKGEVNANAKSFNVDLLAGKSKDIALHLNPRLNIKAFVRNSFLQESWGEEERNITSFPFSPGMYFEMIIYCDVREFKVAVNGVHSLEYKHRFKELSSIDTLEINGDIHLLEVRSW
uniprot
proteins
function
FUNCTION: Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy (PubMed:22246324, PubMed:28077878). Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture (PubMed:22246324, PubMed:28077878). Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52 (PubMed:22246324, PubMed:28077878). Required to restrict infection of bacterial invasion such as S.typhimurium (PubMed:22246324). Also required to restrict infection of Picornaviridae viruses (PubMed:28077878). Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans (PubMed:21288902). {ECO:0000269|PubMed:21288902, ECO:0000269|PubMed:22246324, ECO:0000269|PubMed:28077878}.
uniprot
proteins
mass_dalton
35808
uniprot
proteins
mutagenesis
MUTAGEN 69; /note="R->H: Abolishes localization to cytoplasmic vesicles in case of infection by S.typhimurium."; /evidence="ECO:0000269|PubMed:22246324"; MUTAGEN 190; /note="R->H: Does not affect localization to cytoplasmic vesicles in case of infection by S.typhimurium."; /evidence="ECO:0000269|PubMed:22246324
uniprot
proteins
pubmed
10980616
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19268462
uniprot
proteins
pubmed
21288902
uniprot
proteins
pubmed
22246324
uniprot
proteins
pubmed
28077878
uniprot
proteins
pubmed
8692978
uniprot
proteins
sequence_length
317
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000269|PubMed:22246324}. Cytoplasm, cytosol {ECO:0000269|PubMed:22246324}.
uniprot
proteins