Drd5
entrez
13492
canonical
uniprot
Q8BLD9
canonical
ensembl
ENSMUSG00000039358
resolver
ensp
ENSMUSP00000039691
resolver
enst
ENSMUST00000041646
resolver
genesymbol
Drd5
resolver
uniprot
B2RQS5
resolver
uniprot
Q61439
resolver
uniprot
Q80UB7
resolver
uniprot_entry
B2RQS5_MOUSE
resolver
uniprot_entry
DRD5_MOUSE
resolver
uniprot_sec
Q61439
resolver
uniprot_sec
Q80UB7
resolver
amino_acid_sequence
MLPPGRNGTAHRARLGLQRQLAQVDAPGGSAAPLGPAQVVTAGLLTLLIVWTLLGNVLVCAAIVRSRHLRAKMTNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGAFCDIWVAFDIMCSTASILNLCIISVDRYWAISRPFRYERKMTQRVALVMVALAWTLSILISFIPVQLNWHRDKAGSQGREGLLSNETPWEEGWELDGRTENCDSSLNRTYAISSSLISFYIPVAIMIVTYTRIYRIAQVQIRRISSLERAAEHAQSCRSRGACEPDPSLRASIKKETKVFKTLSVIMGVFVCCWLPFFILNCMVPFCSSGDAQGPRTGFPCVSETTFDIFVWFGWANSSLNPIIYAFNADFRKVFAQLLGCSHLCFRTPVQTVNISNELISYNQDTVFHREIAAAYVHMIPNAVSSGDREVGEEEEAEEEGPFDHMSQISPTTPDGDLAAESVWELDCEEEVSLGKISPLTPNCFHKTA
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for dopamine, a catecholamine neurotransmitter hormone that functions as the brain's 'reward chemical', driving motivation, reinforcement learning and pleasure (By similarity). Dopamine binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). Dopamine receptors can be classified in two categories: (1) DRD5 (together with DRD1) is a D1-type receptor and is coupled to G(s) G proteins, mediating activation of adenylate cyclase activity, while D2-type receptors (DRD2, DRD3 and DRD4) are coupled to G(i)/G(o) G proteins and promote inhibition of adenylate cyclase activity (By similarity). D1- and D2-type dopamine receptors have antagonistic effects, particularly in the brain's striatum, where they govern voluntary movement and reward: D1-type receptors generally stimulate neural activity and promotes action, while D2-type receptors tend to inhibit neural activity and suppress movement (By similarity). DRD5 acts as a key regulator of blood pressure: negatively regulates the renin-angiotensin system (RAS), thereby reducing renal sodium absorption by the kidney (PubMed:12486173, PubMed:21051739). {ECO:0000250|UniProtKB:P21918, ECO:0000269|PubMed:12486173, ECO:0000269|PubMed:21051739}.
uniprot
proteins
mass_dalton
53076
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12486173
uniprot
proteins
pubmed
12679517
uniprot
proteins
pubmed
15696326
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21051739
uniprot
proteins
pubmed
8288218
uniprot
proteins
sequence_length
478
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P21918}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P21918}.
uniprot
proteins
transmembrane_region
TRANSMEM 39..64; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P21918"; TRANSMEM 74..97; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P21918"; TRANSMEM 110..136; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P21918"; TRANSMEM 153..178; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P21918"; TRANSMEM 217..242; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P21918"; TRANSMEM 286..311; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P21918"; TRANSMEM 335..356; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P21918
uniprot
proteins