Pak2
entrez
29432
canonical
uniprot
Q64303
canonical
ensembl
ENSRNOG00000001747
resolver
ensembl
ENSRNOG00060025077
resolver
ensembl
ENSRNOG00065020237
resolver
ensp
ENSRNOP00000040162
resolver
ensp
ENSRNOP00000072644
resolver
ensp
ENSRNOP00060036373
resolver
ensp
ENSRNOP00065027452
resolver
enst
ENSRNOT00000049862
resolver
enst
ENSRNOT00060043834
resolver
enst
ENSRNOT00065034281
resolver
genesymbol
Pak2
resolver
uniprot
Q9QYU0
resolver
uniprot_entry
PAK2_RAT
resolver
uniprot_sec
Q9QYU0
resolver
activity_regulation
ACTIVITY REGULATION: Activated by binding small G proteins. Binding of GTP-bound CDC42 or RAC1 to the autoregulatory region releases monomers from the autoinhibited dimer, enables phosphorylation of Thr-402 and allows the kinase domain to adopt an active structure. Following caspase cleavage, autophosphorylated PAK-2p34 is constitutively active (By similarity). {ECO:0000250|UniProtKB:Q13177}.
uniprot
proteins
amino_acid_sequence
MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRNKIISIFSSTEKGSKKKEKERPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPALNTKGSETSAVVTEEDDDDEDAAPPVIAPRPDHTKSIYTRSVIDPIPAPVGDSNVDSGAKSSDKQKKKAKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLKLAKPLSSLTPLILAAKEAMKSNR
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation. Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Full-length PAK2 stimulates cell survival and cell growth. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Phosphorylates JUN and plays an important role in EGF-induced cell proliferation. Phosphorylates many other substrates including histone H4 to promote assembly of H3.3 and H4 into nucleosomes, BAD, ribosomal protein S6, or MBP. Phosphorylates CASP7, thereby preventing its activity. Additionally, associates with ARHGEF7 and GIT1 to perform kinase-independent functions such as spindle orientation control during mitosis. On the other hand, apoptotic stimuli such as DNA damage lead to caspase-mediated cleavage of PAK2, generating PAK-2p34, an active p34 fragment that translocates to the nucleus and promotes cellular apoptosis involving the JNK signaling pathway. Caspase-activated PAK2 phosphorylates MKNK1 and reduces cellular translation (By similarity). {ECO:0000250|UniProtKB:Q13177}.
uniprot
proteins
mass_dalton
57960
uniprot
proteins
post_translational_modification
PTM: Full-length PAK2 is autophosphorylated when activated by CDC42/p21. Following cleavage, both peptides, PAK-2p27 and PAK-2p34, become highly autophosphorylated. Autophosphorylation of PAK-2p27 can occur in the absence of any effectors and is dependent on phosphorylation of Thr-402, because PAK-2p27 is acting as an exogenous substrate (By similarity). {ECO:0000250|UniProtKB:Q13177}.; PTM: During apoptosis proteolytically cleaved by caspase-3 or caspase-3-like proteases to yield active PAK-2p34. {ECO:0000250|UniProtKB:Q13177}.; PTM: Ubiquitinated, leading to its proteasomal degradation. {ECO:0000250|UniProtKB:Q13177}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
protein_family
STE20 subfamily
uniprot
proteins
pubmed
16396499
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7592896
uniprot
proteins
sequence_length
524
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Serine/threonine-protein kinase PAK 2]: Cytoplasm {ECO:0000250|UniProtKB:Q13177}. Nucleus {ECO:0000250|UniProtKB:Q13177}. Note=MYO18A mediates the cellular distribution of the PAK2-ARHGEF7-GIT1 complex to the inner surface of the cell membrane. {ECO:0000250|UniProtKB:Q13177}.; SUBCELLULAR LOCATION: [PAK-2p34]: Nucleus {ECO:0000250|UniProtKB:Q13177}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q13177}. Membrane {ECO:0000250|UniProtKB:Q13177}; Lipid-anchor {ECO:0000250|UniProtKB:Q13177}. Note=Interaction with ARHGAP10 probably changes PAK-2p34 location to cytoplasmic perinuclear region. Myristoylation changes PAK-2p34 location to the membrane. {ECO:0000250|UniProtKB:Q13177}.
uniprot
proteins