RIN3
entrez
79890
canonical
uniprot
Q8TB24
canonical
ensembl
ENSG00000100599
resolver
ensp
ENSP00000216487
resolver
genesymbol
RIN3
resolver
hgnc
HGNC:18751
resolver
uniprot
Q6NSK7
resolver
uniprot
Q6ZRC2
resolver
uniprot
Q76LB3
resolver
uniprot
Q86U22
resolver
uniprot
Q8NF30
resolver
uniprot
Q8TEE8
resolver
uniprot
Q8WYP4
resolver
uniprot
Q9H6A5
resolver
uniprot
Q9HAG1
resolver
uniprot_entry
Q6NSK7_HUMAN
resolver
uniprot_entry
Q6ZRC2_HUMAN
resolver
uniprot_entry
Q86U22_HUMAN
resolver
uniprot_entry
RIN3_HUMAN
resolver
uniprot_sec
Q76LB3
resolver
uniprot_sec
Q8NF30
resolver
uniprot_sec
Q8TEE8
resolver
uniprot_sec
Q8WYP4
resolver
uniprot_sec
Q9H6A5
resolver
uniprot_sec
Q9HAG1
resolver
amino_acid_sequence
MIRHAGAPARGDPTGPVPVVGKGEEEEEEDGMRLCLPANPKNCLPHRRGISILEKLIKTCPVWLQLSLGQAEVARILHRVVAGMFLVRRDSSSKQLVLCVHFPSLNESSAEVLEYTIKEEKSILYLEGSALVFEDIFRLIAFYCVSRDLLPFTLRLPQAILEASSFTDLETIANLGLGFWDSSLNPPQERGKPAEPPRDRAPGFPLVSSLRPTAHDANCACEIELSVGNDRLWFVNPIFIEDCSSALPTDQPPLGNCPARPLPPTSDATSPTSRWAPRRPPPPPPVLPLQPCSPAQPPVLPALAPAPACPLPTSPPVPAPHVTPHAPGPPDHPNQPPMMTCERLPCPTAGLGPLREEAMKPGAASSPLQQVPAPPLPAKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQLASTLPAPLENAELCTQAMALETPTPGPPREGQSPASQAGTQHPPAQATAHSQSSPEFKGSLASLSDSLGVSVMATDQDSYSTSSTEEELEQFSSPSVKKKPSMILGKARHRLSFASFSSMFHAFLSNNRKLYKKVVELAQDKGSYFGSLVQDYKVYSLEMMARQTSSTEMLQEIRTMMTQLKSYLLQSTELKALVDPALHSEEELEAIVESALYKCVLKPLKEAINSCLHQIHSKDGSLQQLKENQLVILATTTTDLGVTTSVPEVPMMEKILQKFTSMHKAYSPEKKISILLKTCKLIYDSMALGNPGKPYGADDFLPVLMYVLARSNLTEMLLNVEYMMELMDPALQLGEGSYYLTTTYGALEHIKSYDKITVTRQLSVEVQDSIHRWERRRTLNKARASRSSVQDFICVSYLEPEQQARTLASRADTQAQALCAQCAEKFAVERPQAHRLFVLVDGRCFQLADDALPHCIKGYLLRSEPKRDFHFVYRPLDGGGGGGGGSPPCLVVREPNFL
uniprot
proteins
function
FUNCTION: Ras effector protein that functions as a guanine nucleotide exchange (GEF) for RAB5B and RAB31, by exchanging bound GDP for free GTP. Required for normal RAB31 function. {ECO:0000269|PubMed:12972505, ECO:0000269|PubMed:21586568}.
uniprot
proteins
mass_dalton
107854
uniprot
proteins
mutagenesis
MUTAGEN 825; /note="Y->A: Strongly reduced guanine nucleotide exchange factor activity toward RAB31; when associated with A-828."; /evidence="ECO:0000269|PubMed:21586568"; MUTAGEN 828; /note="T->A: Strongly reduced guanine nucleotide exchange factor activity toward RAB31; when associated with A-825."; /evidence="ECO:0000269|PubMed:21586568
uniprot
proteins
protein_family
RIN (Ras interaction/interference) family
uniprot
proteins
pubmed
11733506
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
12972505
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18486601
uniprot
proteins
pubmed
21586568
uniprot
proteins
sequence_length
985
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18486601, ECO:0000269|PubMed:21586568}. Cytoplasmic vesicle {ECO:0000269|PubMed:12972505, ECO:0000269|PubMed:18486601, ECO:0000269|PubMed:21586568}. Early endosome {ECO:0000269|PubMed:18486601}. Note=Activation of tyrosine phosphorylation signaling induces translocation to cytoplasmic vesicles. {ECO:0000269|PubMed:18486601}.
uniprot
proteins