Slc2a5
entrez
56485
canonical
uniprot
Q9WV38
canonical
ensembl
ENSMUSG00000028976
resolver
ensp
ENSMUSP00000030826
resolver
ensp
ENSMUSP00000275815
resolver
enst
ENSMUST00000030826
resolver
genesymbol
Slc2a5
resolver
genesymbol_syn
Glut5
resolver
uniprot
Q8R1N7
resolver
uniprot_entry
GTR5_MOUSE
resolver
uniprot_sec
Q8R1N7
resolver
activity_regulation
ACTIVITY REGULATION: Fructose uptake is inhibited by cytochalasin B. {ECO:0000269|PubMed:12031501}.
uniprot
proteins
amino_acid_sequence
MEEKHQEETGELTLVLALATLIAAFGSSFQYGYNVAAVNSPSEFMQQFYNDTYYDRNEENIESFTLTLLWSLTVSMFPFGGFIGSLMVGTLVNKLGRKGALLFNNIFSILPAILMGCSQIAQSFELIIISRLLVGICAGISSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQLFGLRSLLANEDGWPVLLGLTGVPAGLQLLLLPFFPESPRYLLIQKKDEAAAERALQTLRGWKDVHLEMEEIRKEDEAEKAAGFISVWKLFTMQSLRWQLISMIVLMAGQQLSGVNAIYYYADQIYLSAGVKSDDVQYVTAGTGAVNVFMTILTIFVVELWGRRFLLLVGFSTCLIACLVLTAALALQNTISWMPYISIVCVIVYVIGHALGPSPIPALLITEIFLQSSRPAAYMIGGSVHWLSNFTVGLIFPFIQMGLGPYSFIIFATICFLTTIYIFMVVPETKGRTFIEINQIFTMKNKVSDVYPKKEEELGALPHAILEQ
uniprot
proteins
function
FUNCTION: Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:12031501, PubMed:19091748). Can mediate the uptake of deoxyglucose, but with low efficiency (By similarity). Essential for fructose uptake in the small intestine (PubMed:19091748, PubMed:26071406). Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose (PubMed:19091748). Required for the development of high blood pressure in response to high dietary fructose intake (PubMed:19091748). {ECO:0000250|UniProtKB:P43427, ECO:0000269|PubMed:12031501, ECO:0000269|PubMed:19091748, ECO:0000269|PubMed:26071406}.
uniprot
proteins
mass_dalton
55409
uniprot
proteins
protein_family
Glucose transporter subfamily
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Sugar transporter (TC 2.A.1.1) family
uniprot
proteins
pubmed
12031501
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18417103
uniprot
proteins
pubmed
18496516
uniprot
proteins
pubmed
19091748
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
26071406
uniprot
proteins
sequence_length
501
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:18496516, ECO:0000269|PubMed:19091748, ECO:0000269|PubMed:26071406}; Multi-pass membrane protein {ECO:0000269|PubMed:18496516}. Cell membrane {ECO:0000269|PubMed:12031501, ECO:0000269|PubMed:19091748}; Multi-pass membrane protein {ECO:0000305}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P43427}. Note=Localized on the apical membrane of jejunum villi, but also on lateral plasma membranes of the villi (PubMed:18496516, PubMed:26071406). Transport to the cell membrane is dependent on RAB11A (PubMed:26071406). {ECO:0000269|PubMed:18496516, ECO:0000269|PubMed:26071406}.
uniprot
proteins
transmembrane_region
TRANSMEM 18..38; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P43427"; TRANSMEM 68..90; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P43427"; TRANSMEM 98..118; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P43427"; TRANSMEM 126..148; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P43427"; TRANSMEM 161..181; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P43427"; TRANSMEM 192..212; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P43427"; TRANSMEM 277..297; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P43427"; TRANSMEM 313..333; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P43427"; TRANSMEM 342..362; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:P43427"; TRANSMEM 371..393; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:P43427"; TRANSMEM 412..432; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:P43427"; TRANSMEM 439..459; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:P43427
uniprot
proteins