COTL1
entrez
23406
canonical
uniprot
Q14019
canonical
ensembl
ENSG00000103187
resolver
ensp
ENSP00000262428
resolver
enst
ENST00000262428
resolver
genesymbol
COTL1
resolver
genesymbol_syn
CLP
resolver
hgnc
HGNC:18304
resolver
uniprot
A0A384MTY2
resolver
uniprot
B2RDU3
resolver
uniprot
D3DUL9
resolver
uniprot
Q86XM5
resolver
uniprot_entry
A0A384MTY2_HUMAN
resolver
uniprot_entry
COTL1_HUMAN
resolver
uniprot_sec
B2RDU3
resolver
uniprot_sec
D3DUL9
resolver
uniprot_sec
Q86XM5
resolver
amino_acid_sequence
MATKIDKEACRAAYNLVRDDGSAVIWVTFKYDGSTIVPGEQGAEYQHFIQQCTDDVRLFAFVRFTTGDAMSKRSKFALITWIGENVSGLQRAKTGTDKTLVKEVVQNFAKEFVISDRKELEEDFIKSELKKAGGANYDAQTE
uniprot
proteins
function
FUNCTION: Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis. {ECO:0000269|PubMed:11583571, ECO:0000269|PubMed:19807693}.
uniprot
proteins
mass_dalton
15945
uniprot
proteins
mutagenesis
MUTAGEN 75; /note="K->A: Abolishes actin-binding activity."; /evidence="ECO:0000269|PubMed:11583571"; MUTAGEN 130; /note="K->A: No effect on 5LO-binding activity."; /evidence="ECO:0000269|PubMed:11297527"; MUTAGEN 131; /note="K->A: Abolishes 5LO-binding activity."; /evidence="ECO:0000269|PubMed:11297527"; MUTAGEN 131; /note="K->E: Abolishes 5LO-binding activity."; /evidence="ECO:0000269|PubMed:11297527"; MUTAGEN 131; /note="K->R: No effect on 5LO-binding activity."; /evidence="ECO:0000269|PubMed:11297527
uniprot
proteins
protein_family
Actin-binding proteins ADF family
uniprot
proteins
protein_family
Coactosin subfamily
uniprot
proteins
pubmed
11297527
uniprot
proteins
pubmed
11583571
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15459340
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15754059
uniprot
proteins
pubmed
17070122
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19807693
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
9326934
uniprot
proteins
sequence_length
142
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11583571}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11583571}. Nucleus {ECO:0000269|PubMed:19807693}.
uniprot
proteins