SPC24
entrez
147841
canonical
uniprot
Q8NBT2
canonical
ensembl
ENSG00000161888
resolver
ensp
ENSP00000465075
resolver
ensp
ENSP00000465167
resolver
ensp
ENSP00000465335
resolver
ensp
ENSP00000466688
resolver
ensp
ENSP00000749466
resolver
ensp
ENSP00000749473
resolver
genesymbol
SPC24
resolver
genesymbol_syn
SPBC24
resolver
hgnc
HGNC:26913
resolver
uniprot
B4DZZ7
resolver
uniprot
C9JGC4
resolver
uniprot_entry
SPC24_HUMAN
resolver
uniprot_sec
B4DZZ7
resolver
uniprot_sec
C9JGC4
resolver
amino_acid_sequence
MAAFRDIEEVSQGLLSLLGANRAEAQQRRLLGRHEQVVERLLETQDGAEKQLREILTMEKEVAQSLLNAKEQVHQGGVELQQLEAGLQEAGEEDTRLKASLLQLTRELEELKEIEADLERQEKEVDEDTTVTIPSAVYVAQLYHQVSKIEWDYECEPGMVKGIHHGPSVAQPIHLDSTQLSRKFISDYLWSLVDTEW
uniprot
proteins
function
FUNCTION: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14738735). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). {ECO:0000269|PubMed:14738735, ECO:0000269|PubMed:23085020}.
uniprot
proteins
mass_dalton
22443
uniprot
proteins
protein_family
SPC24 family
uniprot
proteins
pubmed
14699129
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14738735
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15561729
uniprot
proteins
pubmed
15961401
uniprot
proteins
pubmed
15964272
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23085020
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
197
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14738735, ECO:0000269|PubMed:15561729, ECO:0000269|PubMed:15961401, ECO:0000269|PubMed:15964272}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:14738735, ECO:0000269|PubMed:15561729, ECO:0000269|PubMed:15961401, ECO:0000269|PubMed:15964272}. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. {ECO:0000269|PubMed:14738735}.
uniprot
proteins