Alox15
entrez
11687
canonical
uniprot
P39654
canonical
ensembl
ENSMUSG00000018924
resolver
ensp
ENSMUSP00000019068
resolver
enst
ENSMUST00000019068
resolver
genesymbol
Alox15
resolver
genesymbol_syn
Alox12l
resolver
uniprot
A2CF88
resolver
uniprot
Q4FJY9
resolver
uniprot
Q5F2E3
resolver
uniprot
Q6PHB2
resolver
uniprot_entry
A2CF88_MOUSE
resolver
uniprot_entry
LOX15_MOUSE
resolver
uniprot_sec
Q4FJY9
resolver
uniprot_sec
Q5F2E3
resolver
uniprot_sec
Q6PHB2
resolver
amino_acid_sequence
MGVYRIRVSTGDSVYAGSNNEVYLWLIGQHGEASLGKLFRPCRNSEAEFKVDVSEYLGPLLFVRVQKWHYLKEDAWFCNWISVKGPGDQGSEYTFPCYRWVQGTSILNLPEGTGCTVVEDSQGLFRNHREEELEERRSLYRWGNWKDGTILNVAATSISDLPVDQRFREDKRLEFEASQVLGTMDTVINFPKNTVTCWKSLDDFNYVFKSGHTKMAERVRNSWKEDAFFGYQFLNGANPMVLKRSTCLPARLVFPPGMEKLQAQLDEELKKGTLFEADFFLLDGIKANVILCSQQYLAAPLVMLKLQPDGQLLPIAIQLELPKTGSTPPPIFTPLDPPMDWLLAKCWVRSSDLQLHELQAHLLRGHLVAEVFAVATMRCLPSVHPVFKLLVPHLLYTMEINVRARSDLISERGFFDKVMSTGGGGHLDLLKQAGAFLTYSSLCPPDDLAERGLLDIDTCFYAKDALQLWQVMNRYVVGMFDLYYKTDQAVQDDYELQSWCQEITEIGLQGAQDRGFPTSLQSRAQACHFITMCIFTCTAQHSSIHLGQLDWFYWVPNAPCTMRLPPPKTKDATMEKLMATLPNPNQSTLQINVVWLLGRRQAVMVPLGQHSEEHFPNPEAKAVLKKFREELAALDKEIEIRNKSLDIPYEYLRPSLVENSVAI
uniprot
proteins
ec_number
1.13.11.-
uniprot
proteins
ec_number
1.13.11.12
uniprot
proteins
ec_number
1.13.11.31
uniprot
proteins
ec_number
1.13.11.33
uniprot
proteins
function
FUNCTION: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators (PubMed:8188678). It inserts peroxyl groups at C12 or C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing both 12-hydroperoxyeicosatetraenoate/12-HPETE and 15-hydroperoxyeicosatetraenoate/15-HPETE (PubMed:8188678). It may then act on 12-HPETE to produce hepoxilins, which may show pro-inflammatory properties (By similarity). Can also peroxidize linoleate ((9Z,12Z)-octadecadienoate) to 13-hydroperoxyoctadecadienoate. May participate in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs)like resolvin D5 ((7S,17S)-diHPDHA) and (7S,14S)-diHPDHA, that actively down-regulate the immune response and have anti-aggregation properties with platelets. Can convert epoxy fatty acids to hydroperoxy-epoxides derivatives followed by an intramolecular nucleophilic substitution leading to the formation of monocyclic endoperoxides (By similarity). Plays an important role during the maintenance of self-tolerance by peroxidizing membrane-bound phosphatidylethanolamine which can then signal the sorting process for clearance of apoptotic cells during inflammation and prevent an autoimmune response (PubMed:22503541). In addition to its role in the immune and inflammatory responses, this enzyme may play a role in epithelial wound healing in the cornea through production of lipoxin A4 (LXA(4)) and docosahexaenoic acid-derived neuroprotectin D1 (NPD1; 10R,17S-HDHA), both lipid autacoids exhibit anti-inflammatory and neuroprotective properties (PubMed:15708862). Furthermore, it may regulate actin polymerization which is crucial for several biological processes such as the phagocytosis of apoptotic cells (PubMed:11278875). It is also implicated in the generation of endogenous ligands for peroxisome proliferator activated receptor (PPAR-gamma), hence modulating macrophage development and function (PubMed:10432118). It may also exert a negative effect on skeletal development by regulating bone mass through this pathway (PubMed:14716014). As well as participates in ER stress and downstream inflammation in adipocytes, pancreatic islets, and liver (PubMed:22215650). Finally, it is also involved in the cellular response to IL13/interleukin-13 (By similarity). {ECO:0000250|UniProtKB:P16050, ECO:0000250|UniProtKB:Q02759, ECO:0000269|PubMed:10432118, ECO:0000269|PubMed:11278875, ECO:0000269|PubMed:14716014, ECO:0000269|PubMed:15708862, ECO:0000269|PubMed:22215650, ECO:0000269|PubMed:22503541, ECO:0000269|PubMed:8188678}.
uniprot
proteins
mass_dalton
75445
uniprot
proteins
mutagenesis
MUTAGEN 663; /note="Missing: Abolishes arachidonate 15-lipoxygenase activity. Abolishes arachidonate 12-lipoxygenase activity. Abolishes linoleate 13-lipoxygenase activity."; /evidence="ECO:0000269|PubMed:8188678
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis. {ECO:0000269|PubMed:8188678}.
uniprot
proteins
protein_family
Lipoxygenase family
uniprot
proteins
pubmed
10432118
uniprot
proteins
pubmed
11278875
uniprot
proteins
pubmed
14716014
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15708862
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22215650
uniprot
proteins
pubmed
22503541
uniprot
proteins
pubmed
7811740
uniprot
proteins
pubmed
8188678
uniprot
proteins
pubmed
8798642
uniprot
proteins
sequence_length
663
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:11278875}. Cell membrane {ECO:0000269|PubMed:11278875}; Peripheral membrane protein {ECO:0000250|UniProtKB:P16050}. Lipid droplet {ECO:0000250|UniProtKB:P16050}. Note=Predominantly cytosolic; becomes enriched at membranes upon calcium binding (PubMed:11278875). Translocates from the cytosol to the plasma membrane when stimulated by IL13/interleukin-13 and in macrophages binding apoptotic cells (PubMed:11278875). {ECO:0000269|PubMed:11278875}.
uniprot
proteins