CRTC1
entrez
23373
canonical
uniprot
Q6UUV9
canonical
ensembl
ENSG00000105662
resolver
ensp
ENSP00000323332
resolver
ensp
ENSP00000345001
resolver
genesymbol
CRTC1
resolver
genesymbol_syn
KIAA0616
resolver
genesymbol_syn
MECT1
resolver
genesymbol_syn
TORC1
resolver
genesymbol_syn
WAMTP1
resolver
hgnc
HGNC:16062
resolver
uniprot
A6NMG5
resolver
uniprot
O75114
resolver
uniprot
Q6Y3A3
resolver
uniprot
Q7LDZ2
resolver
uniprot
Q8IUL3
resolver
uniprot
Q8IZ34
resolver
uniprot
Q8IZL1
resolver
uniprot
Q8N6W3
resolver
uniprot
Q96AI8
resolver
uniprot
Q9H801
resolver
uniprot_entry
CRTC1_HUMAN
resolver
uniprot_sec
A6NMG5
resolver
uniprot_sec
O75114
resolver
uniprot_sec
Q6Y3A3
resolver
uniprot_sec
Q7LDZ2
resolver
uniprot_sec
Q8IUL3
resolver
uniprot_sec
Q8IZ34
resolver
uniprot_sec
Q8IZL1
resolver
uniprot_sec
Q8N6W3
resolver
uniprot_sec
Q96AI8
resolver
uniprot_sec
Q9H801
resolver
amino_acid_sequence
MATSNNPRKFSEKIALHNQKQAEETAAFEEVMKDLSLTRAARLQLQKSQYLQLGPSRGQYYGGSLPNVNQIGSGTMDLPFQTPFQSSGLDTSRTTRHHGLVDRVYRERGRLGSPHRRPLSVDKHGRQADSCPYGTMYLSPPADTSWRRTNSDSALHQSTMTPTQPESFSSGSQDVHQKRVLLLTVPGMEETTSEADKNLSKQAWDTKKTGSRPKSCEVPGINIFPSADQENTTALIPATHNTGGSLPDLTNIHFPSPLPTPLDPEEPTFPALSSSSSTGNLAANLTHLGIGGAGQGMSTPGSSPQHRPAGVSPLSLSTEARRQQASPTLSPLSPITQAVAMDALSLEQQLPYAFFTQAGSQQPPPQPQPPPPPPPASQQPPPPPPPQAPVRLPPGGPLLPSASLTRGPQPPPLAVTVPSSLPQSPPENPGQPSMGIDIASAPALQQYRTSAGSPANQSPTSPVSNQGFSPGSSPQHTSTLGSVFGDAYYEQQMAARQANALSHQLEQFNMMENAISSSSLYSPGSTLNYSQAAMMGLTGSHGSLPDSQQLGYASHSGIPNIILTVTGESPPSLSKELTSSLAGVGDVSFDSDSQFPLDELKIDPLTLDGLHMLNDPDMVLADPATEDTFRMDRL
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving CRTC1 is found in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. Translocation t(11;19)(q21;p13) with MAML2. The fusion protein consists of the N-terminus of CRTC1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of CRTC1 has been detected in a small number of mucoepidermoid carcinomas.
uniprot
proteins
function
FUNCTION: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons (By similarity). In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. {ECO:0000250|UniProtKB:Q157S1, ECO:0000250|UniProtKB:Q68ED7, ECO:0000269|PubMed:23699513}.; FUNCTION: (Microbial infection) Plays a role of coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:16809310}.
uniprot
proteins
mass_dalton
67300
uniprot
proteins
post_translational_modification
PTM: Phosphorylation/dephosphorylation states of Ser-151 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation is mediated by SIKs (SIK1 and SIK2), is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs by LKB1 (By similarity). {ECO:0000250|UniProtKB:Q68ED7}.
uniprot
proteins
protein_family
TORC family
uniprot
proteins
pubmed
12539049
uniprot
proteins
pubmed
14506290
uniprot
proteins
pubmed
14536081
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14720503
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15589160
uniprot
proteins
pubmed
15729701
uniprot
proteins
pubmed
16809310
uniprot
proteins
pubmed
16817901
uniprot
proteins
pubmed
16980408
uniprot
proteins
pubmed
17210223
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23699513
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
30611118
uniprot
proteins
pubmed
9734811
uniprot
proteins
sequence_length
634
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15589160}. Nucleus {ECO:0000269|PubMed:15589160}. Note=Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins (PubMed:16817901). Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels (PubMed:15589160). Light stimulation triggers a nuclear accumulation in the suprachiasmatic nucleus (SCN) of the brain (By similarity). {ECO:0000250|UniProtKB:Q68ED7, ECO:0000269|PubMed:15589160, ECO:0000269|PubMed:16817901}.
uniprot
proteins