Cbr4
entrez
234309
canonical
uniprot
Q91VT4
canonical
ensembl
ENSMUSG00000031641
resolver
ensp
ENSMUSP00000034058
resolver
enst
ENSMUST00000034058
resolver
genesymbol
Cbr4
resolver
uniprot
Q3UBY4
resolver
uniprot
Q8BXV1
resolver
uniprot_entry
CBR4_MOUSE
resolver
uniprot_sec
Q3UBY4
resolver
uniprot_sec
Q8BXV1
resolver
amino_acid_sequence
MDKVCAVFGGSRGIGRAVAQLMAQKGYRLAIVSRNLEVAKVTAGELGGNHLAFRCDVAKEQDVQSTFQEMEKHLGPVNFLVNAAGINRDSLLVRTKTEDMISQLHTNLLGSMLTCKAAMKTMIQQGGSIVNVGSIIGLKGNVGQSAYSATKGGLVGFSRSLAKEVARKKIRVNVVAPGFIRTDMTRHLKEEHFKKNIPLGRFGETLEVAHAVVFLLESPYITGHVLIVDGGLQLTV
uniprot
proteins
ec_number
1.1.1.100
uniprot
proteins
ec_number
1.6.5.10
uniprot
proteins
function
FUNCTION: Component of the heterotetramer complex KAR (3-ketoacyl-[acyl carrier protein] reductase or 3-ketoacyl-[ACP] reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible for the 3-ketoacyl-ACP reductase activity of the mtFAS, reduces 3-oxoacyl-[ACP] to (3R)-hydroxyacyl-[ACP] in a NADPH-dependent manner with no chain length preference, thereby participating in mitochondrial fatty acid biosynthesis. The homotetramer has NADPH-dependent quinone reductase activity (in vitro), hence could play a role in protection against cytotoxicity of exogenous quinones. As a heterotetramer, it can also reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro). {ECO:0000250|UniProtKB:Q8N4T8}.
uniprot
proteins
mass_dalton
25415
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000250|UniProtKB:Q8N4T8}.
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
sequence_length
236
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:Q8N4T8}.
uniprot
proteins