P0DSE2
uniprot
P0DSE2
canonical
amino_acid_sequence
MSNQVLCCVVLCLLGANTVDGGITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSQIVNDFQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSIRSSYEQYFGPGTRLTVTEDLKNVFPPKVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADCGFTSESYQQGVLSATILYEILLGKATLYAVLVSALVLMAMVKRKDSRG
uniprot
proteins
function
FUNCTION: The beta chain of TRAV27*01J42*01C*01/TRBV19*01J2S7*01C*02 alpha-beta T cell receptor (TR) clonotype that is specific for HLA-A*02:01-restricted M/matrix protein 1 immunodominant epitope GILGFVFTL of influenza A virus (IAV). Classified as a public TCR clonotype, it is preferentially selected in effector memory CD8-positive T cells among multiple HLA-A*02:01 carriers/individuals and confers long-lived immunity against IAV infection. Can cross-recognize sporadically emerging IAV variants by molecular mimicry, inducing immunity toward different influenza strains (PubMed:12796775, PubMed:18275829, PubMed:1833769, PubMed:27036003, PubMed:29997621, PubMed:7807026). Antigen recognition initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell differentiation into effector/memory T cells (By similarity). {ECO:0000250|UniProtKB:A0A075B6N1, ECO:0000269|PubMed:12796775, ECO:0000269|PubMed:18275829, ECO:0000269|PubMed:1833769, ECO:0000269|PubMed:27036003, ECO:0000269|PubMed:29997621, ECO:0000269|PubMed:7807026}.
uniprot
proteins
mass_dalton
34792
uniprot
proteins
mutagenesis
MUTAGEN 49; /note="D->A,S: Abolishes binding to M/matrix protein 1 peptide antigen."; /evidence="ECO:0000269|PubMed:18275829"; MUTAGEN 69; /note="Q->A,E: Abolishes binding to M/matrix protein 1 peptide antigen."; /evidence="ECO:0000269|PubMed:18275829"; MUTAGEN 70; /note="I->A,G,N: Abolishes binding to M/matrix protein 1 peptide antigen."; /evidence="ECO:0000269|PubMed:18275829"; MUTAGEN 115; /note="R->A,H: Abolishes binding to M/matrix protein 1 peptide antigen."; /evidence="ECO:0000269|PubMed:18275829
uniprot
proteins
pubmed
11096259
uniprot
proteins
pubmed
12796775
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
18275829
uniprot
proteins
pubmed
1833769
uniprot
proteins
pubmed
19568742
uniprot
proteins
pubmed
27036003
uniprot
proteins
pubmed
29997621
uniprot
proteins
pubmed
3860845
uniprot
proteins
pubmed
7807026
uniprot
proteins
pubmed
8550091
uniprot
proteins
sequence_length
310
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29997621}.
uniprot
proteins
transmembrane_region
TRANSMEM 277..299; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins