PACSIN2
entrez
11252
canonical
uniprot
Q9UNF0
canonical
ensembl
ENSG00000100266
resolver
ensp
ENSP00000263246
resolver
ensp
ENSP00000385372
resolver
ensp
ENSP00000385952
resolver
ensp
ENSP00000489297
resolver
genesymbol
PACSIN2
resolver
hgnc
HGNC:8571
resolver
uniprot
O95921
resolver
uniprot
Q6FIA3
resolver
uniprot
Q96HV9
resolver
uniprot
Q9H0D3
resolver
uniprot
Q9NPN1
resolver
uniprot
Q9Y4V2
resolver
uniprot_entry
PACN2_HUMAN
resolver
uniprot_entry
Q6FIA3_HUMAN
resolver
uniprot_sec
O95921
resolver
uniprot_sec
Q96HV9
resolver
uniprot_sec
Q9H0D3
resolver
uniprot_sec
Q9NPN1
resolver
uniprot_sec
Q9Y4V2
resolver
amino_acid_sequence
MSVTYDDSVGVEVSSDSFWEVGNYKRTVKRIDDGHRLCSDLMNCLHERARIEKAYAQQLTEWARRWRQLVEKGPQYGTVEKAWMAFMSEAERVSELHLEVKASLMNDDFEKIKNWQKEAFHKQMMGGFKETKEAEDGFRKAQKPWAKKLKEVEAAKKAHHAACKEEKLAISREANSKADPSLNPEQLKKLQDKIEKCKQDVLKTKEKYEKSLKELDQGTPQYMENMEQVFEQCQQFEEKRLRFFREVLLEVQKHLDLSNVAGYKAIYHDLEQSIRAADAVEDLRWFRANHGPGMAMNWPQFEEWSADLNRTLSRREKKKATDGVTLTGINQTGDQSLPSKPSSTLNVPSNPAQSAQSQSSYNPFEDEDDTGSTVSEKDDTKAKNVSSYEKTQSYPTDWSDDESNNPFSSTDANGDSNPFDDDATSGTEVRVRALYDYEGQEHDELSFKAGDELTKMEDEDEQGWCKGRLDNGQVGLYPANYVEAIQ
uniprot
proteins
function
FUNCTION: Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus (PubMed:21693584, PubMed:23129763, PubMed:23236520, PubMed:23596323). Essential for endothelial organization in sprouting angiogenesis, modulates CDH5-based junctions. Facilitates endothelial front-rear polarity during migration by recruiting EHD4 and MICALL1 to asymmetric adherens junctions between leader and follower cells (By similarity). {ECO:0000250|UniProtKB:Q9WVE8, ECO:0000269|PubMed:21693584, ECO:0000269|PubMed:23129763, ECO:0000269|PubMed:23236520, ECO:0000269|PubMed:23596323}.; FUNCTION: (Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer (PubMed:29891700). Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes (PubMed:31242077). Involved in lipid droplet formation, which is important for HCV virion assembly (PubMed:31801866). {ECO:0000269|PubMed:29891700, ECO:0000269|PubMed:31242077, ECO:0000269|PubMed:31801866}.
uniprot
proteins
mass_dalton
55739
uniprot
proteins
mutagenesis
MUTAGEN 313; /note="S->A: Increased protein interaction with HCVNS5A."; /evidence="ECO:0000269|PubMed:31801866"; MUTAGEN 313; /note="S->E: Decreased protein interaction with HCVNS5A."; /evidence="ECO:0000269|PubMed:31801866
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by casein kinase 2 (CK2). Phosphorylation by PKC probably decreases the membrane binding and tubulation capacities of PACSIN2, thereby modulating the lifetime of caveolae (By similarity). {ECO:0000250|UniProtKB:Q9WVE8}.
uniprot
proteins
protein_family
PACSIN family
uniprot
proteins
pubmed
10431838
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
11082044
uniprot
proteins
pubmed
11179684
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19549836
uniprot
proteins
pubmed
20188097
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21693584
uniprot
proteins
pubmed
22323287
uniprot
proteins
pubmed
22573331
uniprot
proteins
pubmed
23129763
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23236520
uniprot
proteins
pubmed
23596323
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29891700
uniprot
proteins
pubmed
31242077
uniprot
proteins
pubmed
31801866
uniprot
proteins
sequence_length
486
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9WVE8}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9WVE8}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9WVE8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9WVE8}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9WVE8}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q9WVE8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9WVE8}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9WVE8}. Early endosome {ECO:0000250|UniProtKB:Q9WVE8}. Recycling endosome membrane {ECO:0000250}. Cell membrane {ECO:0000250|UniProtKB:Q9WVE8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9WVE8}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9WVE8}. Cell projection {ECO:0000269|PubMed:31242077}. Membrane, caveola {ECO:0000269|PubMed:22323287}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9WVE8}. Note=Detected at the neck of flask-shaped caveolae. Localization to tubular recycling endosomes probably requires interaction with MICALL1 and EHD1. {ECO:0000250|UniProtKB:Q9WVE8}.
uniprot
proteins