Sh2b2
entrez
23921
canonical
uniprot
Q9JID9
canonical
ensembl
ENSMUSG00000005057
resolver
ensp
ENSMUSP00000005188
resolver
ensp
ENSMUSP00000142398
resolver
ensp
ENSMUSP00000142728
resolver
ensp
ENSMUSP00000231669
resolver
ensp
ENSMUSP00000231670
resolver
ensp
ENSMUSP00000231676
resolver
ensp
ENSMUSP00000231692
resolver
ensp
ENSMUSP00000231693
resolver
enst
ENSMUST00000005188
resolver
enst
ENSMUST00000196397
resolver
enst
ENSMUST00000196447
resolver
genesymbol
Sh2b2
resolver
genesymbol_syn
Aps
resolver
uniprot
A0A0G2JED4
resolver
uniprot
O88936
resolver
uniprot
Q6PG00
resolver
uniprot_entry
A0A0G2JED4_MOUSE
resolver
uniprot_entry
SH2B2_MOUSE
resolver
uniprot_sec
O88936
resolver
uniprot_sec
Q6PG00
resolver
amino_acid_sequence
MNGATPSSAAAPAPVPDWRQFCELHAQVAAVDFAHKFCRFLRDNPTYDTPDAGTSFSRHFAANFLAVFSEEVRRVLGSAADTMEPEPAVTSVTSALKTATYGHSRSSEDVSAHAATKARVRKGFSLRNMSLCVVDGVRDLWHRRSSPEPDGGATPKAAEPASEPRDKWTRRLRLARTLAAKVELVDIQREGALRFMVADDAASGPGGTAQWQKCRLLLRRAVAGERFRLEFFVPPKASRPKVSIPLSAIIEVRTTMPLEMPEKDNTFVLKVENGAEYILETIDSLQKHSWVADIQGCVDPGDSEEDTGLSCARGGCLASRVASCSCELLTDADMPRPPETTTAVGAVVTAPHGRARDTVGESLAHVPLETFLQTLESSGGVSENNNPGDEGAELDTDAEAELELSDYPWFHGTLSRVKAAQLVLAGGPRSHGLFVIRQSETRPGECVLTFNFQGKAKHLRLSLNGHGQCHVQHLWFQSVFDMLRHFHTHPIPLESGGSADITLRSYVRAQGPPPDPGPAPNTAAPVPACWTEPAGQHYFSSLATATCPPASPSNGAGASSSSGSSSSATSLPPRPAEGPLSAHSRSNSTEHLLDAASGATEEPTEATLGRARAVENQYSFY
uniprot
proteins
function
FUNCTION: Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3 (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
66557
uniprot
proteins
post_translational_modification
PTM: Tyrosine phosphorylated by JAK2, KIT and other kinases activated by B-cell receptor in response to stimulation with cytokines, IL3, IL5, PDGF, IGF1, IGF2, CSF2/GM-CSF and cross-linking of the B-cell receptor complex. {ECO:0000269|PubMed:10872802}.
uniprot
proteins
protein_family
SH2B adapter family
uniprot
proteins
pubmed
10872802
uniprot
proteins
pubmed
12444928
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
621
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Cytoplasmic before PDGF stimulation. After PDGF stimulation, localized at the cell membrane and peripheral region (By similarity). {ECO:0000250}.
uniprot
proteins