Setd3
entrez
299295
canonical
uniprot
G3V6U9
canonical
ensembl
ENSRNOG00000006587
resolver
ensembl
ENSRNOG00055028714
resolver
ensembl
ENSRNOG00060019035
resolver
ensembl
ENSRNOG00065028495
resolver
ensp
ENSRNOP00000009121
resolver
ensp
ENSRNOP00000054006
resolver
ensp
ENSRNOP00055040927
resolver
ensp
ENSRNOP00060026963
resolver
ensp
ENSRNOP00065040311
resolver
enst
ENSRNOT00000009120
resolver
enst
ENSRNOT00000057179
resolver
enst
ENSRNOT00055049727
resolver
enst
ENSRNOT00060032966
resolver
enst
ENSRNOT00065049159
resolver
genesymbol
Setd3
resolver
uniprot
D4A7S1
resolver
uniprot
Q5FWY6
resolver
uniprot_entry
D4A7S1_RAT
resolver
uniprot_entry
SETD3_RAT
resolver
uniprot_sec
Q5FWY6
resolver
amino_acid_sequence
MGKKSRVKTQKSGTGATATVSPKEILNLTSELLQKCSSPAPGPGKEWEEYTQIRALVEKIRKKQKGLSVTFDGKREDYFPDLMKWASENGASVEGFEMVNFKEEGFGLRATRDIKAEELFLWVPRKLLMTVESAKNSILGPLYSQDRILQAMGNIALAFHLLCERASPNSFWQPYIQTLPSEYDTPLYFEEEEVRCLQSTQAIHDVFSQYKNTARQYAYFYKVIQTHPHANKLPLKDSFTYEDYRWAVSSVMTRQNQIPTEDGSRVTLALIPLWDMCNHTNGLITTGYNLEDDRCECVALQDFQAGDQIYIFYGTRSNAEFVIHSGFFFDNNSHDRVKIKLGVSKSDRLYAMKAEVLARAGIPTSSVFALHFTEPPISAQLLAFLRVFCMTEEELKEHLLGDSAIDRIFTLGNSEFPVSWDNEVKLWTFLEDRASLLLKTYKTTIEEDKTVLKNPDLSVRATMAIKLRLGEKEILEKAVKSAAMNREYYRKHMEERAPLPRYEESDLGLLEGGVGDSRLPLVLRKLEEEAGVQESLSLTETVSKVKAAENGLVNGESLIPNGTRSENESLSPEESENTTGDTEESSGSMDAVKERL
uniprot
proteins
ec_number
2.1.1.85
uniprot
proteins
function
FUNCTION: Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' (PubMed:30526847). Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (By similarity). Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin (By similarity). {ECO:0000250|UniProtKB:Q86TU7, ECO:0000269|PubMed:30526847}.
uniprot
proteins
mass_dalton
67420
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by GSK3B, which is required for recognition by the SCF(FBXW7) complex and subsequent degradation. {ECO:0000250|UniProtKB:Q86TU7}.; PTM: Ubiquitinated by the SCF(FBXW7) complex following phosphorylation by GSK3B, leading to its degradation by the proteasome. {ECO:0000250|UniProtKB:Q86TU7}.
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
SETD3 actin-histidine methyltransferase family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
30526847
uniprot
proteins
sequence_length
596
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q86TU7}. Nucleus {ECO:0000250|UniProtKB:Q91WC0}. Note=Localizes mainly in the cytoplasm. {ECO:0000250|UniProtKB:Q86TU7}.
uniprot
proteins