Dph1
entrez
116905
canonical
uniprot
Q5NCQ5
canonical
ensembl
ENSMUSG00000078789
resolver
ensp
ENSMUSP00000042162
resolver
enst
ENSMUST00000044949
resolver
genesymbol
Dph1
resolver
genesymbol_syn
Dph2l1
resolver
genesymbol_syn
Ovca1
resolver
uniprot
Q80UX6
resolver
uniprot
Q8R445
resolver
uniprot_entry
DPH1_MOUSE
resolver
uniprot_sec
Q80UX6
resolver
uniprot_sec
Q8R445
resolver
amino_acid_sequence
MAALVVSETAEPGSRVGPGRGRISRGRLANQIPPEVLNNPQLQAAVQVLPSNYNFEIPKTIWRIQQAQAKKVALQMPEGLLLFACTIVDILERFTEAEVMVMGDVTYGACCVDDFTARALGVDFLVHYGHSCLVPMDTSVQDFRVLYVFVDIRIDTAHLLDSVRLTFTPGSSLALVSTIQFVSTLQAAAQELKADYHISVPQCKPLSPGEILGCTSPRLSKEVEAVVYLGDGRFHLESVMIANPNIPAYRYDPYGKVLSREYYDHQRMQATRQEAIAAARSAKSWGLILGTLGRQGSPKILEHLESQLRNLGLPFVRLLLSEIFPSKLSLLPEVDVWVQVACPRLSIDWGSAFPKPLLTPYEAAVALKDISWQQPYPMDFYSGSSLGPWTVNYGRDRAPRGLCQPASDKVQQGSRGGSPAPACESCNCADQKATSPAP
uniprot
proteins
ec_number
2.5.1.108
uniprot
proteins
function
FUNCTION: Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2 (PubMed:15485916, PubMed:24895408). DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase (By similarity). Acts as a tumor suppressor (PubMed:14744934, PubMed:15661533, PubMed:24895408). {ECO:0000250|UniProtKB:P40487, ECO:0000269|PubMed:14744934, ECO:0000269|PubMed:15485916, ECO:0000269|PubMed:15661533, ECO:0000269|PubMed:24895408}.
uniprot
proteins
mass_dalton
48004
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; peptidyl-diphthamide biosynthesis.
uniprot
proteins
protein_family
DPH1 subfamily
uniprot
proteins
protein_family
DPH1/DPH2 family
uniprot
proteins
pubmed
11527402
uniprot
proteins
pubmed
14744934
uniprot
proteins
pubmed
15485916
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15661533
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21203470
uniprot
proteins
pubmed
24895408
uniprot
proteins
sequence_length
438
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11527402}. Cytoplasm {ECO:0000269|PubMed:11527402}. Note=Punctate, primarily perinuclear localization.
uniprot
proteins