Cyba
entrez
13057
canonical
uniprot
Q61462
canonical
ensembl
ENSMUSG00000006519
resolver
ensp
ENSMUSP00000017604
resolver
ensp
ENSMUSP00000148320
resolver
genesymbol
Cyba
resolver
uniprot
B3VQI8
resolver
uniprot
Q3U820
resolver
uniprot
Q9CWB9
resolver
uniprot
Q9D2W2
resolver
uniprot_entry
B3VQI8_MOUSE
resolver
uniprot_entry
CY24A_MOUSE
resolver
uniprot_sec
Q3U820
resolver
uniprot_sec
Q9CWB9
resolver
uniprot_sec
Q9D2W2
resolver
amino_acid_sequence
MGQIEWAMWANEQALASGLILITGGIVATAGRFTQWYFGAYSIAAGVLICLLEYPRGKRKKGSTMERCGQKYLTSVVKLFGPLTRNYYVRAALHFLLSVPAGFLLATILGTVCLAIASVIYLLAAIRGEQWTPIEPKPKERPQVGGTIKQPPTNPPPRPPAEVRKKPSEGEEEAASAGGPQVNPMPVTDEVV
uniprot
proteins
function
FUNCTION: Subunit of NADPH oxidase complexes that is required for the NADPH oxidase activity that generates, in various cell types, superoxide from molecular oxygen utilizing NADPH as an electron donor (By similarity). Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction. Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane. This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide (By similarity). {ECO:0000250|UniProtKB:P13498}.
uniprot
proteins
mass_dalton
20748
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated at Lys-149 likely by RNF145. {ECO:0000269|PubMed:26194095}.; PTM: Phosphorylation at Thr-147 enhances NADPH oxidase activity by promoting NCF1/p47-phox binding. {ECO:0000250|UniProtKB:P13498}.
uniprot
proteins
protein_family
P22phox family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19755709
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21551061
uniprot
proteins
pubmed
2597164
uniprot
proteins
pubmed
26194095
uniprot
proteins
pubmed
28351984
uniprot
proteins
sequence_length
192
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P13498}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P13498}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..30; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P13498"; TRANSMEM 36..53; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P13498"; TRANSMEM 87..104; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P13498"; TRANSMEM 106..126; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P13498
uniprot
proteins