Rtn4r
entrez
65079
canonical
uniprot
Q99PI8
canonical
ensembl
ENSMUSG00000043811
resolver
ensp
ENSMUSP00000062924
resolver
enst
ENSMUST00000059589
resolver
genesymbol
Rtn4r
resolver
genesymbol_syn
Ngr1
resolver
genesymbol_syn
Nogor
resolver
uniprot
Q80WQ1
resolver
uniprot_entry
RTN4R_MOUSE
resolver
uniprot_sec
Q80WQ1
resolver
amino_acid_sequence
MKRASSGGSRLLAWVLWLQAWRVATPCPGACVCYNEPKVTTSCPQQGLQAVPTGIPASSQRIFLHGNRISHVPAASFQSCRNLTILWLHSNALARIDAAAFTGLTLLEQLDLSDNAQLHVVDPTTFHGLGHLHTLHLDRCGLRELGPGLFRGLAALQYLYLQDNNLQALPDNTFRDLGNLTHLFLHGNRIPSVPEHAFRGLHSLDRLLLHQNHVARVHPHAFRDLGRLMTLYLFANNLSMLPAEVLMPLRSLQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCNLPQRLADRDLKRLAASDLEGCAVASGPFRPIQTSQLTDEELLSLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDTPPGNGSGPRHINDSPFGTLPSSAEPPLTALRPGGSEPPGLPTTGPRRRPGCSRKNRTRSHCRLGQAGSGASGTGDAEGSGALPALACSLAPLGLALVLWTVLGPC
uniprot
proteins
function
FUNCTION: Receptor for RTN4, OMG and MAG (PubMed:11201742, PubMed:12089450, PubMed:15504325, PubMed:18411262, PubMed:22923615). Functions as a receptor for the sialylated gangliosides GT1b and GM1 (PubMed:18411262). Besides, functions as a receptor for chondroitin sulfate proteoglycans (PubMed:22406547). Can also bind heparin (PubMed:22406547). Intracellular signaling cascades are triggered via the coreceptor NGFR (By similarity). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200). Mediates axonal growth inhibition (By similarity). Mediates axonal growth inhibition and plays a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system (PubMed:11201742, PubMed:12089450, PubMed:15504325, PubMed:22923615). Plays a role in postnatal brain development (PubMed:27339102). Required for normal axon migration across the brain midline and normal formation of the corpus callosum (PubMed:27339102). Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG (PubMed:26335717). Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development (PubMed:20093372). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). {ECO:0000250|UniProtKB:Q9BZR6, ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:12089450, ECO:0000269|PubMed:15504325, ECO:0000269|PubMed:20093372, ECO:0000269|PubMed:22325200, ECO:0000269|PubMed:22406547, ECO:0000269|PubMed:22923615, ECO:0000269|PubMed:26335717, ECO:0000269|PubMed:27339102}.
uniprot
proteins
mass_dalton
50987
uniprot
proteins
post_translational_modification
PTM: N-glycosylated (PubMed:29095159). O-glycosylated. Contains terminal sialic acid groups on its glycan chains (By similarity). {ECO:0000250|UniProtKB:Q99M75, ECO:0000269|PubMed:29095159}.
uniprot
proteins
protein_family
Nogo receptor family
uniprot
proteins
pubmed
11201742
uniprot
proteins
pubmed
11891768
uniprot
proteins
pubmed
12089450
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15504325
uniprot
proteins
pubmed
15647357
uniprot
proteins
pubmed
18411262
uniprot
proteins
pubmed
19052207
uniprot
proteins
pubmed
19367338
uniprot
proteins
pubmed
20093372
uniprot
proteins
pubmed
22325200
uniprot
proteins
pubmed
22406547
uniprot
proteins
pubmed
22923615
uniprot
proteins
pubmed
26335717
uniprot
proteins
pubmed
27339102
uniprot
proteins
pubmed
29095159
uniprot
proteins
sequence_length
473
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11201742, ECO:0000269|PubMed:22325200}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11201742}. Membrane raft {ECO:0000250|UniProtKB:Q9BZR6}. Cell projection, dendrite {ECO:0000269|PubMed:22325200}. Cell projection, axon {ECO:0000269|PubMed:22325200}. Perikaryon {ECO:0000250|UniProtKB:Q99M75}. Note=Detected along dendrites and axons, close to synapses, but clearly excluded from synapses. {ECO:0000269|PubMed:22325200}.
uniprot
proteins