Suz12
entrez
52615
canonical
uniprot
Q80U70
canonical
ensembl
ENSMUSG00000017548
resolver
ensp
ENSMUSP00000017692
resolver
ensp
ENSMUSP00000126932
resolver
enst
ENSMUST00000017692
resolver
enst
ENSMUST00000163272
resolver
genesymbol
Suz12
resolver
genesymbol_syn
D11Ertd530e
resolver
genesymbol_syn
Kiaa0160
resolver
uniprot
B1AQE5
resolver
uniprot
E9PW15
resolver
uniprot
Q80Y10
resolver
uniprot
Q99L07
resolver
uniprot_entry
E9PW15_MOUSE
resolver
uniprot_entry
SUZ12_MOUSE
resolver
uniprot_sec
B1AQE5
resolver
uniprot_sec
Q80Y10
resolver
uniprot_sec
Q99L07
resolver
amino_acid_sequence
MAPQKHGGGGGGGSGPSAGSGGGGFGGSAAAVAAAASGGKSGGGGCGGGGSYSASSSSAAAAAAAAGAAVLPVKKPKMEHVQADHELFLQAFEKPTQIYRFLRTRNLIAPIFLHRTLTYMSHRNSRTSIKRKTFKVDDMLSKVEKMKGEQESHSLSAHLQLTFTGFFHKNDKPSQNSENEQNSVTLEVLLVKVCHKKRKDVSCPIRQVPTGKKQVPLNPDLNQTKPGNFPSLAVSSNEFEPSNSHMVKSYSLLFRVTRPGRREFNGMINGETNENIDVSEELPARRKRNREDGEKTFVAQMTVFDKNRRLQLLDGEYEVAMQEMEECPISKKRATWETILDGKRLPPFETFSQGPTLQFTLRWTGETNDKSTAPVAKPLATRNSESLHQENKPGSVKPAQTIAVKETLTTELQTRKEKDNSNESRQKLRIFYQFLYNNNTRQQTEARDDLHCPWCTLNCRKLYSLLKHLKLCHSRFIFNYVYHPKGARIDVSINECYDGSYAGNPQDIHRQPGFAFSRNGPVKRTPITHILVCRPKRTKASMSEFLESEDGEVEQQRTYSSGHNRLYFHSDTCLPLRPQEMEVDSEDEKDPEWLREKTITQIEEFSDVNEGEKEVMKLWNLHVMKHGFIADNQMNHACMLFVENYGQKIIKKNLCRNFMLHLVSMHDFNLISIMSIDKAVTKLREMQQKLEKGESATPSNEEIAEEQNGTANGFSETNSKEKALETDGVSGVPKQSKKQKL
uniprot
proteins
function
FUNCTION: Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXA7, HOXB6 and HOXC8. {ECO:0000250|UniProtKB:Q15022, ECO:0000269|PubMed:15385962, ECO:0000269|PubMed:15516932, ECO:0000269|PubMed:17339329, ECO:0000269|PubMed:31914400}.
uniprot
proteins
mass_dalton
83026
uniprot
proteins
post_translational_modification
PTM: Sumoylated, probably by PIAS2. {ECO:0000250|UniProtKB:Q15022}.
uniprot
proteins
protein_family
VEFS (VRN2-EMF2-FIS2-SU(Z)12) family
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15385962
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15516932
uniprot
proteins
pubmed
15684044
uniprot
proteins
pubmed
16415857
uniprot
proteins
pubmed
16712789
uniprot
proteins
pubmed
17339329
uniprot
proteins
pubmed
19026780
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20144788
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22226355
uniprot
proteins
pubmed
23970558
uniprot
proteins
pubmed
31914400
uniprot
proteins
sequence_length
741
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16415857}. Chromosome {ECO:0000269|PubMed:16415857}. Note=Localizes to the inactive X chromosome in trophoblast stem cells.
uniprot
proteins