Snx17
entrez
266781
canonical
uniprot
Q8BVL3
canonical
ensembl
ENSMUSG00000029146
resolver
ensp
ENSMUSP00000031029
resolver
enst
ENSMUST00000031029
resolver
genesymbol
Snx17
resolver
uniprot
Q8R0N8
resolver
uniprot_entry
SNX17_MOUSE
resolver
uniprot_sec
Q8R0N8
resolver
amino_acid_sequence
MHFSIPETESRSGDSGGSAYVAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVVPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQQVPTEEVSLEVLLSNGQKVLVTVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSFVRKLQEFELPYVSVTSLRSQEYKIVLRKSYWDSAYDDDVMENRVGLNLLYAQTVSDIEHGWILVTKEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGGTSSPSRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMVDELMVKKSGGSIRKMLRRRVGGTLRRSDSQQAVKSPPLLESPDASRESMVKLSSKLSAVSLRGIGSPSTDASASAVHGNFAFEGIGDEDL
uniprot
proteins
function
FUNCTION: Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:12169628, PubMed:16052210). Binds to NPxY sequences in the cytoplasmic tails of target cargos (By similarity). Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (By similarity). Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16052210, PubMed:18276590). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (By similarity). {ECO:0000250|UniProtKB:Q15036, ECO:0000269|PubMed:12169628, ECO:0000269|PubMed:16052210, ECO:0000269|PubMed:18276590}.
uniprot
proteins
mass_dalton
52797
uniprot
proteins
protein_family
Sorting nexin family
uniprot
proteins
pubmed
12169628
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16052210
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18276590
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19967056
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
470
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q15036}. Early endosome {ECO:0000250|UniProtKB:Q15036}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q15036}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q15036}; Cytoplasmic side {ECO:0000250|UniProtKB:Q15036}.
uniprot
proteins