DEFA3
entrez
1668
canonical
uniprot
P59666
canonical
ensembl
ENSG00000239839
resolver
ensp
ENSP00000328359
resolver
ensp
ENSP00000537455
resolver
ensp
ENSP00000630620
resolver
enst
ENST00000327857
resolver
enst
ENST00000867396
resolver
enst
ENST00000960561
resolver
genesymbol
DEFA3
resolver
genesymbol_syn
DEF3
resolver
hgnc
HGNC:2762
resolver
uniprot
P11479
resolver
uniprot
Q14125
resolver
uniprot
Q6EZE9
resolver
uniprot_entry
DEF3_HUMAN
resolver
uniprot_entry
Q6EZE9_HUMAN
resolver
uniprot_sec
P11479
resolver
uniprot_sec
Q14125
resolver
amino_acid_sequence
MRTLAILAAILLVALQAQAEPLQARADEVAAAPEQIAADIPEVVVSLAWDESLAPKHPGSRKNMDCYCRIPACIAGERRYGTCIYQGRLWAFCC
uniprot
proteins
function
FUNCTION: Effector molecule of the innate immune system that acts via antibiotic-like properties against a broad array of infectious agents including bacteria, fungi, and viruses (PubMed:15616305, PubMed:15772169, PubMed:17142766). Possesses the ability to neutralize bacterial toxins such as B.anthracis lethal factor, Clostridium difficile cytotoxin B as well as leukocidin produced by Staphylococcus aureus (PubMed:15772169, PubMed:18435932, PubMed:25963798). Also blocks herpes simplex virus infection by interacting with envelope glycoprotein B and thus preventing its binding to heparan sulfate, the receptor for attachment (PubMed:17142766). {ECO:0000269|PubMed:15616305, ECO:0000269|PubMed:15772169, ECO:0000269|PubMed:15894545, ECO:0000269|PubMed:17142766, ECO:0000269|PubMed:17452329, ECO:0000269|PubMed:18435932, ECO:0000269|PubMed:2006422, ECO:0000269|PubMed:25963798}.
uniprot
proteins
mass_dalton
10245
uniprot
proteins
protein_family
Alpha-defensin family
uniprot
proteins
pubmed
1339298
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616305
uniprot
proteins
pubmed
15772169
uniprot
proteins
pubmed
15894545
uniprot
proteins
pubmed
17142766
uniprot
proteins
pubmed
17452329
uniprot
proteins
pubmed
18435932
uniprot
proteins
pubmed
2006422
uniprot
proteins
pubmed
25963798
uniprot
proteins
pubmed
2917986
uniprot
proteins
pubmed
2918759
uniprot
proteins
pubmed
29282039
uniprot
proteins
pubmed
3174637
uniprot
proteins
pubmed
4056036
uniprot
proteins
pubmed
8325384
uniprot
proteins
pubmed
8477861
uniprot
proteins
sequence_length
94
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29282039}.
uniprot
proteins