Rictor
entrez
78757
canonical
uniprot
Q6QI06
canonical
ensembl
ENSMUSG00000050310
resolver
ensp
ENSMUSP00000051809
resolver
ensp
ENSMUSP00000333319
resolver
genesymbol
Rictor
resolver
genesymbol_syn
Kiaa1999
resolver
uniprot
E9QPE0
resolver
uniprot
Q0VAV4
resolver
uniprot
Q69Z40
resolver
uniprot
Q6PDL2
resolver
uniprot
Q6RI74
resolver
uniprot
Q8BPH9
resolver
uniprot
Q8CBF2
resolver
uniprot_entry
RICTR_MOUSE
resolver
uniprot_sec
E9QPE0
resolver
uniprot_sec
Q0VAV4
resolver
uniprot_sec
Q69Z40
resolver
uniprot_sec
Q6PDL2
resolver
uniprot_sec
Q6RI74
resolver
uniprot_sec
Q8BPH9
resolver
uniprot_sec
Q8CBF2
resolver
amino_acid_sequence
MAAIGRGRSLKNLRIRGRNDSGEENVPLDLTREPSDNLREILQNVAKLQGVSNMRKLGHLNNFTKLLCDIGHSEEKLGFNYEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKVLKLKVDYLIARCIDIQQSNEVERTQALRLVRKMITVNASLFPSSVANSLIAVGNDGLQERDRMVRACIAIICELALQNPEVVALRGGLNTILKNVIDCQLSRINEALITTILHLLNHPKTRQYVRADVELERILAPYTDFHYRHSPDTAEGQLKEDREARFLASKMGIIATFRSWAGIINLCKPGNSGIQSLIGVLCIPNMEIRRGLLEVLYDIFRLPLPVVTDEFIEALLSVDPGRFQDSWRLSDGFVAAEAKTILPHRARSRPDLMDNYLALILSAFIRNGLLEGLVEVITNSDDHISVRATILLGELLHMANTILPHSHSHHLHCLPTLMNMAASFDIPKEKRLRASAALNCLNRFHEMKKRGPKPYSLHLDHIIQKAIATHHKRDQYLRVQKDIFVLKDTEEALLINLRDSQVLQHKENLDWDWNLIGTILKWPNVNLRNYKDEQLHRFVRRLLYFYKPSSKLYASLDLDLAKSKQLTVVGCQFTEFLLESEEDGQGYLEDLVKDIVQWLNASSGVKPERSLQNNGLLTTLSQHYFLFIGTLSCHPHGVKMLEKCSVFQCLLNLCSLKNQDHLIKLTVSSLDYSRDGLARVILSKILTAATDACRLYATKHLRVLLRANVEFFNNWGIELLVTQLHDKNKTISSEALDILDEACEDKANLHALIQMKPALSHLGDKGLLLLLRFLSIPKGFSYLNERGYVAKQLEKWHKEYNSKYVDLIEEQLNEALTTYRKPIDGDNYVRRSNQRLQRPHVYLPVHLYGQLVHHKTGCHLLEVQSIITELCHNVRTPDLDKWEDIKKLKASLWALGNIGSSNWGLNLLQEENVIPDILKLAKQCEVLSIRGTCVYVLGLIAKTKQGCDILKCHSWDSVRHSRKHLWPVVPDDVEQLCNELSSVPSTLSLNSESTSSRHNSESESAPSSMFMLEDDRFGSTSTSTFFLDINEDAEPAFYDRPGPIKDKNSFPFFGSSKLVKNRILNSLTLPTKKHRSSSDPKGGKLSSENKTSNRRIRTLTEPSVDLNHSEDFTSSSAQKSLQLEPSFVGNKHLEDAGSTPSIGENDLKFPKSFGTETHRENTSRERLVVEGSASSHIKIRSQSFNTDTTTSGISSMSSSPSRETVAVDPTAMDTDCGSLSTVVSTKTVKTSHYLTPQSNHLSLSKSNSVSLVPPGSSHTLPRRAQSLKAPSIATIKSLADCNFSYTSSRDAFGYATLKRLQQQRMHPSLSHSEALASPAKDVLFTDTITMKANSFESRLTPSRFMKALSYASLDKEDLLSPINHNTLQRSSSVRSMVSSATYGGSDDYIGLALPVDINDIFQIKDVPYFQSKHVPPPDDRGARMFSHDGAGLSSGAGGLVKNSFHLLRQQMSLTEIMNSVHSDASLFLESTEDTGLQEHTDDNCLYCVCIELLGFQPSNQLSSICSHSDLQDIPYSDWCEQTIHNPLEVVPSKFSGISGCSDGASQEEGSASSTKSTELLLGVKTIPDDTPMCRILLRKEVLRLVVNLSSSVSTKCHETGLLTIKEKYPQTFDDICLYSEVSHLLSHCTFRLQCRRFIQELFQDVQFLQMHEEAEAVLAIPPIQPIVDESAES
uniprot
proteins
function
FUNCTION: Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output (PubMed:16221682, PubMed:16962653, PubMed:17141160, PubMed:24670654, PubMed:29232555, PubMed:33850054). In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 (PubMed:16221682, PubMed:16962653, PubMed:17141160, PubMed:24670654, PubMed:33850054). In contrast to mTORC1, mTORC2 is nutrient-insensitive (By similarity). Within the mTORC2 complex, RICTOR probably acts as a molecular adapter (By similarity). RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 (By similarity). mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation (PubMed:16221682, PubMed:16962653, PubMed:17141160). mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (PubMed:33850054). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (PubMed:23142081, PubMed:23388827). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors (By similarity). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin (By similarity). Plays an essential role in embryonic growth and development (PubMed:16962829). {ECO:0000250|UniProtKB:Q6R327, ECO:0000269|PubMed:16221682, ECO:0000269|PubMed:16962653, ECO:0000269|PubMed:16962829, ECO:0000269|PubMed:17141160, ECO:0000269|PubMed:23142081, ECO:0000269|PubMed:23388827, ECO:0000269|PubMed:24670654, ECO:0000269|PubMed:29232555, ECO:0000269|PubMed:33850054}.
uniprot
proteins
mass_dalton
191570
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MTOR; when part of mTORC2 (By similarity). Phosphorylated at Thr-1135 by RPS6KB1 downstream of the mTORC1 complex: phosphorylation of RICTOR inhibits mTORC2 signaling by creating a binding site for 14-3-3 proteins (By similarity). Phosphorylated at Ser-1234 by GSK3B in response to endoplasmic stress, inhibiting mTORC2 signaling (By similarity). {ECO:0000250|UniProtKB:Q6R327}.; PTM: Ubiquitinated by the SCF(FBXW7) complex, leading to its degradation by the proteasome. Deubiquitinated by USP9X; deubiquitination stabilizes RICTOR and enhances its binding to MTOR, thus promoting mTORC2 complex assembly. {ECO:0000250|UniProtKB:Q6R327}.; PTM: Acetylated by EP300/p300 in response to glucose, leading to activate the mTORC2 complex (By similarity). Acetylation by BLOC1S1/GCN5L1 in response to hypotoxic stress protects RICTOR against ubiquitination and subsequent degradation by the proteasome (By similarity). {ECO:0000250|UniProtKB:Q6R327}.
uniprot
proteins
protein_family
RICTOR family
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15467718
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16221682
uniprot
proteins
pubmed
16962653
uniprot
proteins
pubmed
16962829
uniprot
proteins
pubmed
17141160
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23142081
uniprot
proteins
pubmed
23388827
uniprot
proteins
pubmed
24670654
uniprot
proteins
pubmed
25418727
uniprot
proteins
pubmed
29232555
uniprot
proteins
pubmed
33378666
uniprot
proteins
pubmed
33850054
uniprot
proteins
sequence_length
1708
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6R327}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6R327}. Lysosome membrane {ECO:0000250|UniProtKB:Q6R327}. Note=The mTORC2 complex localizes to membranes: mTORC2 is active at the plasma membrane, endoplasmic reticulum membrane and lysosomes. In lysosomal membrane, mTORC2 is sensitive to lysosomal positioning in the cell. {ECO:0000250|UniProtKB:Q6R327}.
uniprot
proteins