Lgmn
entrez
19141
canonical
uniprot
O89017
canonical
ensembl
ENSMUSG00000021190
resolver
ensp
ENSMUSP00000021607
resolver
ensp
ENSMUSP00000105647
resolver
ensp
ENSMUSP00000181020
resolver
enst
ENSMUST00000021607
resolver
enst
ENSMUST00000110020
resolver
genesymbol
Lgmn
resolver
genesymbol_syn
Prsc1
resolver
uniprot
A2RTI3
resolver
uniprot
Q3UE99
resolver
uniprot_entry
A2RTI3_MOUSE
resolver
uniprot_entry
LGMN_MOUSE
resolver
uniprot_entry
Q3UE99_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by cystatin-C. {ECO:0000269|PubMed:24407422}.
uniprot
proteins
amino_acid_sequence
MTWRVAVLLSLVLGAGAVPVGVDDPEDGGKHWVVIVAGSNGWYNYRHQADACHAYQIIHRNGIPDEQIIVMMYDDIANSEENPTPGVVINRPNGTDVYKGVLKDYTGEDVTPENFLAVLRGDAEAVKGKGSGKVLKSGPRDHVFIYFTDHGATGILVFPNDDLHVKDLNKTIRYMYEHKMYQKMVFYIEACESGSMMNHLPDDINVYATTAANPKESSYACYYDEERGTYLGDWYSVNWMEDSDVEDLTKETLHKQYHLVKSHTNTSHVMQYGNKSISTMKVMQFQGMKHRASSPISLPPVTHLDLTPSPDVPLTILKRKLLRTNDVKESQNLIGQIQQFLDARHVIEKSVHKIVSLLAGFGETAERHLSERTMLTAHDCYQEAVTHFRTHCFNWHSVTYEHALRYLYVLANLCEAPYPIDRIEMAMDKVCLSHY
uniprot
proteins
ec_number
3.4.22.34
uniprot
proteins
function
FUNCTION: Has a strict specificity for hydrolysis of asparaginyl bonds (PubMed:24407422, PubMed:9742219, PubMed:9891971). Can also cleave aspartyl bonds slowly, especially under acidic conditions (PubMed:24407422, PubMed:9742219, PubMed:9891971). Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system (By similarity). Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol (PubMed:37347855). Required for normal lysosomal protein degradation in renal proximal tubules (PubMed:17350006, PubMed:21292981). Required for normal degradation of internalized EGFR (PubMed:21292981). Plays a role in the regulation of cell proliferation via its role in EGFR degradation (PubMed:21292981). {ECO:0000250|UniProtKB:Q99538, ECO:0000269|PubMed:17350006, ECO:0000269|PubMed:21292981, ECO:0000269|PubMed:24407422, ECO:0000269|PubMed:37347855, ECO:0000269|PubMed:9742219, ECO:0000269|PubMed:9891971}.
uniprot
proteins
mass_dalton
49373
uniprot
proteins
mutagenesis
MUTAGEN 44; /note="N->A: Nearly abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:24407422"; MUTAGEN 46; /note="R->A: Nearly abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:24407422"; MUTAGEN 47; /note="H->A: 54% Loss of activity."; /evidence="ECO:0000269|PubMed:9891971"; MUTAGEN 52; /note="C->S: No loss of activity."; /evidence="ECO:0000269|PubMed:9891971"; MUTAGEN 150; /note="H->A: Complete loss of activity. Abolishes autocatalytic processing."; /evidence="ECO:0000269|PubMed:24407422, ECO:0000269|PubMed:9891971"; MUTAGEN 189; /note="E->A: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:24407422"; MUTAGEN 191; /note="C->A,S: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:24407422, ECO:0000269|PubMed:9891971"; MUTAGEN 233; /note="D->A: Abolishes enzyme activity. Abolishes autocatalytic processing."; /evidence="ECO:0000269|PubMed:24407422"; MUTAGEN 311; /note="D->A: Nearly abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:24407422
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000305|PubMed:24407422}.; PTM: Activated by autocatalytic processing at pH 4. {ECO:0000250|UniProtKB:Q99538}.
uniprot
proteins
protein_family
Peptidase C13 family
uniprot
proteins
pubmed
17350006
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21292981
uniprot
proteins
pubmed
24407422
uniprot
proteins
pubmed
37347855
uniprot
proteins
pubmed
9742219
uniprot
proteins
pubmed
9821970
uniprot
proteins
pubmed
9891971
uniprot
proteins
sequence_length
435
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:21292981, ECO:0000269|PubMed:9742219}.
uniprot
proteins