CATSPER3
entrez
347732
canonical
uniprot
Q86XQ3
canonical
ensembl
ENSG00000152705
resolver
ensp
ENSP00000282611
resolver
enst
ENST00000282611
resolver
genesymbol
CATSPER3
resolver
hgnc
HGNC:20819
resolver
uniprot
Q86XS6
resolver
uniprot_entry
CTSR3_HUMAN
resolver
uniprot_sec
Q86XS6
resolver
activity_regulation
ACTIVITY REGULATION: The CatSper calcium channel is indirectly activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2 (PubMed:21412338, PubMed:21412339, PubMed:26989199). The CatSper calcium channel is directly inhibited by endocannabinoid 2-arachidonoylglycerol (2AG) (PubMed:26989199). Indirect activation by progesterone takes place via the following mechanism: progesterone binds and activates the acylglycerol lipase ABHD2, which in turn mediates hydrolysis of 2AG inhibitor, relieving inhibition of the CatSper channel (PubMed:26989199). The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers (PubMed:21412338, PubMed:21412339). Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH (PubMed:21412338, PubMed:21412339). {ECO:0000269|PubMed:21412338, ECO:0000269|PubMed:21412339, ECO:0000269|PubMed:26989199}.
uniprot
proteins
amino_acid_sequence
MSQHRHQRHSRVISSSPVDTTSVGFCPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTVTSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMKVYVDPINYWKNGYNLLDVIIIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASVLLLLFLLMYIFAILGFCLFGSPDNGDHDNWGNLAAAFFTLFSLATVDGWTDLQKQLDNREFALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQEMLMGEKQVILQRQQEEISRLMHIQKNADCTSFSELVENFKKTLSHTDPMVLDDFGTSLPFIDIYFSTLDYQDTTVHKLQELYYEIVHVLSLMLEDLPQEKPQSLEKVDEK
uniprot
proteins
function
FUNCTION: Pore-forming subunit of the CatSper complex, a sperm-specific voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. {ECO:0000269|PubMed:21412338, ECO:0000269|PubMed:21412339}.
uniprot
proteins
mass_dalton
46422
uniprot
proteins
protein_family
Cation channel sperm-associated (TC 1.A.1.19) family
uniprot
proteins
pubmed
12646162
uniprot
proteins
pubmed
12932298
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17347248
uniprot
proteins
pubmed
21412338
uniprot
proteins
pubmed
21412339
uniprot
proteins
pubmed
26989199
uniprot
proteins
sequence_length
398
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:Q80W99}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q80W99}.
uniprot
proteins
transmembrane_region
TRANSMEM 49..71; /note="Helical; Name=Segment S1"; /evidence="ECO:0000250|UniProtKB:Q80W99"; TRANSMEM 81..107; /note="Helical; Name=Segment S2"; /evidence="ECO:0000250|UniProtKB:Q80W99"; TRANSMEM 109..131; /note="Helical; Name=Segment S3"; /evidence="ECO:0000250|UniProtKB:Q80W99"; TRANSMEM 144..160; /note="Helical; Name=Segment S4"; /evidence="ECO:0000250|UniProtKB:Q80W99"; TRANSMEM 169..195; /note="Helical; Name=Segment S5"; /evidence="ECO:0000250|UniProtKB:Q80W99"; TRANSMEM 243..268; /note="Helical; Name=Segment S6"; /evidence="ECO:0000250|UniProtKB:Q80W99
uniprot
proteins