Cyp4a12
entrez
266674
canonical
uniprot
P24464
canonical
ensembl
ENSRNOG00000008842
resolver
ensp
ENSRNOP00000012448
resolver
enst
ENSRNOT00000012448
resolver
genesymbol
Cyp4a12
resolver
genesymbol_syn
Cyp4a-8
resolver
genesymbol_syn
Cyp4a8
resolver
uniprot
Q642E9
resolver
uniprot_entry
CP4AC_RAT
resolver
uniprot_sec
Q642E9
resolver
activity_regulation
ACTIVITY REGULATION: Activated by cytochrome b5 and phosphatidylserine. {ECO:0000269|PubMed:15618658}.
uniprot
proteins
amino_acid_sequence
MSGSALSFTIFPGSILGFLQIATVLTVLLLLFKTAQFYLHRRWLLRATQQFPSPPSHWFFGHKIPKDQEFQDILTRVKNFPSACPQWLWGSNVRIQVYDPDYMKLILGRSDPKSHHSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDTLKPYVGIMADSVRIMLDKWEQIVGQDSTLEIFQHITLMTLDTIMKCAFSQEGSVQLDRKYKSYIKAVEDLNNLSFFRIRNIFHQNDIIYSLSSNGRKARSAWQLAHEHTDQVIKSRKAQLQDEEELQKVKQKRRLDFLDILLFARIENGSSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQGCRKEIQSLLGDGASITWDDLDKMPYTTMCIKEALRIYPPVTAVSRMLSTPVTFPDGRSLPKGITVMLSFYGLHHNPTVWPNPEVFDPYRFAPESSRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRFELLPDPTRIPIPIPRLVLKSKNGIYLRLKKLQ
uniprot
proteins
ec_number
1.14.14.1
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of saturated and unsaturated fatty acids (PubMed:10620324, PubMed:10869363, PubMed:15618658). May act as a major omega-hydroxylase for dodecanoic (lauric) acid in kidney (PubMed:10620324, PubMed:10869363, PubMed:15618658). At preglomerular arteries, may participate in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:15618658). Can also catalyze the oxidation of the penultimate carbon (omega-1 oxidation) of fatty acids with lower efficiency, displaying a preference for the (R)-stereoisomer (PubMed:10869363). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10620324, PubMed:10869363, PubMed:15618658). {ECO:0000269|PubMed:10620324, ECO:0000269|PubMed:10869363, ECO:0000269|PubMed:15618658}.
uniprot
proteins
mass_dalton
58559
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid metabolism. {ECO:0000305|PubMed:15618658}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
10620324
uniprot
proteins
pubmed
10869363
uniprot
proteins
pubmed
11139583
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15618658
uniprot
proteins
pubmed
1980193
uniprot
proteins
sequence_length
508
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15618658}; Multi-pass membrane protein {ECO:0000255}. Microsome membrane {ECO:0000269|PubMed:15618658}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..30; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 120..140; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins