RABEP1
entrez
9135
canonical
uniprot
Q15276
canonical
ensembl
ENSG00000029725
resolver
ensp
ENSP00000339569
resolver
ensp
ENSP00000445408
resolver
ensp
ENSP00000546403
resolver
ensp
ENSP00000546411
resolver
ensp
ENSP00000581676
resolver
ensp
ENSP00000666741
resolver
genesymbol
RABEP1
resolver
genesymbol_syn
RAB5EP
resolver
genesymbol_syn
RABPT5
resolver
genesymbol_syn
RABPT5A
resolver
hgnc
HGNC:17677
resolver
uniprot
B2RAG7
resolver
uniprot
B4DMM4
resolver
uniprot
O95369
resolver
uniprot
Q8IVX3
resolver
uniprot_entry
B4DMM4_HUMAN
resolver
uniprot_entry
RABE1_HUMAN
resolver
uniprot_sec
B2RAG7
resolver
uniprot_sec
O95369
resolver
uniprot_sec
Q8IVX3
resolver
amino_acid_sequence
MAQPGPASQPDVSLQQRVAELEKINAEFLRAQQQLEQEFNQKRAKFKELYLAKEEDLKRQNAVLQAAQDDLGHLRTQLWEAQAEMENIKAIATVSENTKQEAIDEVKRQWREEVASLQAVMKETVRDYEHQFHLRLEQERTQWAQYRESAEREIADLRRRLSEGQEEENLENEMKKAQEDAEKLRSVVMPMEKEIAALKDKLTEAEDKIKELEASKVKELNHYLEAEKSCRTDLEMYVAVLNTQKSVLQEDAEKLRKELHEVCHLLEQERQQHNQLKHTWQKANDQFLESQRLLMRDMQRMEIVLTSEQLRQVEELKKKDQEDDEQQRLNKRKDHKKADVEEEIKIPVVCALTQEESSAQLSNEEEHLDSTRGSVHSLDAGLLLPSGDPFSKSDNDMFKDGLRRAQSTDSLGTSGSLQSKALGYNYKAKSAGNLDESDFGPLVGADSVSENFDTASLGSLQMPSGFMLTKDQERAIKAMTPEQEETASLLSSVTQGMESAYVSPSGYRLVSETEWNLLQKEVHNAGNKLGRRCDMCSNYEKQLQGIQIQEAETRDQVKKLQLMLRQANDQLEKTMKDKQELEDFIKQSSEDSSHQISALVLRAQASEILLEELQQGLSQAKRDVQEQMAVLMQSREQVSEELVRLQKDNDSLQGKHSLHVSLQQAEDFILPDTTEALRELVLKYREDIINVRTAADHVEEKLKAEILFLKEQIQAEQCLKENLEETLQLEIENCKEEIASISSLKAELERIKVEKGQLESTLREKSQQLESLQEIKISLEEQLKKETAAKATVEQLMFEEKNKAQRLQTELDVSEQVQRDFVKLSQTLQVQLERIRQADSLERIRAILNDTKLTDINQLPET
uniprot
proteins
function
FUNCTION: Rab effector protein acting as linker between gamma-adaptin, RAB4A and RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Involved in KCNH1 channels trafficking to and from the cell membrane (PubMed:22841712). Forms a complex with RABGEF1 that stimulates RABGEF1-mediated nucleotide exchange on RAB5A (PubMed:9323142). Mediates the traffic of PKD1:PKD2 complex from the endoplasmic reticulum through the Golgi to the cilium (By similarity). {ECO:0000250|UniProtKB:O35551, ECO:0000269|PubMed:10698684, ECO:0000269|PubMed:11452015, ECO:0000269|PubMed:12773381, ECO:0000269|PubMed:22841712, ECO:0000269|PubMed:8521472, ECO:0000269|PubMed:9323142}.
uniprot
proteins
mass_dalton
99290
uniprot
proteins
mutagenesis
MUTAGEN 439; /note="F->A,V,I,M,L: Abolishes the interaction with AP1G1, AP1G2, GGA1, GGA2 and GGA3."; /evidence="ECO:0000269|PubMed:14665628"; MUTAGEN 440; /note="G->A,E,V,S: Abolishes the interaction with AP1G1, AP1G2, GGA1, GGA2 and GGA3."; /evidence="ECO:0000269|PubMed:14665628"; MUTAGEN 441; /note="P->A,D,E: Reduces the interaction with AP1G1 and GGA3."; /evidence="ECO:0000269|PubMed:14665628"; MUTAGEN 441; /note="P->A: Abolishes the interaction with AP1G2, GGA1 and GGA2."; /evidence="ECO:0000269|PubMed:14665628"; MUTAGEN 441; /note="P->D,E: Reduces the interaction with AP1G2, GGA1, GGA2."; /evidence="ECO:0000269|PubMed:14665628"; MUTAGEN 441; /note="P->K,F,G,V: Abolishes the interaction with AP1G1, AP1G2, GGA1, GGA2 and GGA3."; /evidence="ECO:0000269|PubMed:14665628"; MUTAGEN 442; /note="L->A,V,I: Abolishes the interaction with AP1G1, AP1G2, GGA1, GGA2 and GGA3."; /evidence="ECO:0000269|PubMed:14665628"; MUTAGEN 812; /note="D->K: No effect on RAB5A binding affinity."; /evidence="ECO:0000269|PubMed:15378032"; MUTAGEN 815; /note="E->K: No effect on RAB5A binding affinity."; /evidence="ECO:0000269|PubMed:15378032"; MUTAGEN 818; /note="Q->W: Strongly decreases RAB5A binding affinity."; /evidence="ECO:0000269|PubMed:15378032"; MUTAGEN 820; /note="D->K: Strongly decreases RAB5A binding affinity."; /evidence="ECO:0000269|PubMed:15378032"; MUTAGEN 821; /note="F->R: Strongly decreases RAB5A binding affinity."; /evidence="ECO:0000269|PubMed:15378032"; MUTAGEN 822; /note="V->D: Strongly decreases RAB5A binding affinity."; /evidence="ECO:0000269|PubMed:15378032"; MUTAGEN 826; /note="Q->A: Strongly decreases RAB5A binding affinity."; /evidence="ECO:0000269|PubMed:15378032"; MUTAGEN 829; /note="Q->A: Strongly decreases RAB5A binding affinity."; /evidence="ECO:0000269|PubMed:15378032
uniprot
proteins
post_translational_modification
PTM: Proteolytic cleavage by caspases in apoptotic cells causes loss of endosome fusion activity. {ECO:0000269|PubMed:9321397}.
uniprot
proteins
protein_family
Rabaptin family
uniprot
proteins
pubmed
10508479
uniprot
proteins
pubmed
10698684
uniprot
proteins
pubmed
11452015
uniprot
proteins
pubmed
12505986
uniprot
proteins
pubmed
12773381
uniprot
proteins
pubmed
14665628
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15378032
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20098723
uniprot
proteins
pubmed
20682791
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
22841712
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
41348103
uniprot
proteins
pubmed
8521472
uniprot
proteins
pubmed
9045618
uniprot
proteins
pubmed
9321397
uniprot
proteins
pubmed
9323142
uniprot
proteins
sequence_length
862
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Early endosome. Recycling endosome. Cytoplasmic vesicle.
uniprot
proteins