GSG2
entrez
83903
canonical
uniprot
Q8TF76
canonical
ensembl
ENSG00000177602
resolver
ensp
ENSP00000325290
resolver
genesymbol
GSG2
resolver
genesymbol
HASPIN
resolver
genesymbol_syn
GSG2
resolver
hgnc
HGNC:19682
resolver
uniprot
A0PJ70
resolver
uniprot
Q5U5K3
resolver
uniprot
Q96MN1
resolver
uniprot
Q9BXS7
resolver
uniprot_entry
A0PJ70_HUMAN
resolver
uniprot_entry
HASP_HUMAN
resolver
uniprot_sec
Q5U5K3
resolver
uniprot_sec
Q96MN1
resolver
uniprot_sec
Q9BXS7
resolver
activity_regulation
ACTIVITY REGULATION: Constitutive activity that does not require phosphorylation. Specifically inhibited by 3-(1H-indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine (CHR-6494). {ECO:0000269|PubMed:19918057, ECO:0000269|PubMed:21658950, ECO:0000269|PubMed:21804608}.
uniprot
proteins
amino_acid_sequence
MAASLPGPGSRLFRTYGAADGRRQRRPGREAAQWFPPQDRRRFFNSSGSSDASIGDPSQSDDPDDPDDPDFPGSPVRRRRRRPGGRVPKDRPSLTVTPKRWKLRARPSLTVTPRRLGLRARPPQKCSTPCGPLRLPPFPSRDSGRLSPDLSVCGQPRDGDELGISASLFSSLASPCPGSPTPRDSVISIGTSACLVAASAVPSGLHLPEVSLDRASLPCSQEEATGGAKDTRMVHQTRASLRSVLFGLMNSGTPEDSEFRADGKNMRESCCKRKLVVGNGPEGPGLSSTGKRRATGQDSCQERGLQEAVRREHQEASVPKGRIVPRGIDRLERTRSSRKSKHQEATETSLLHSHRFKKGQKLGKDSFPTQDLTPLQNVCFWTKTRASFSFHKKKIVTDVSEVCSIYTTATSLSGSLLSECSNRPVMNRTSGAPSSWHSSSMYLLSPLNTLSISNKKASDAEKVYGECSQKGPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKTSLKKLHYTLNGKSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMDEDLFTGDGDYQFDIYRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMTFKTKCNTPAMKQIKRKIQEFHRTMLNFSSATDLLCQHSLFK
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000269|PubMed:11228240, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:17084365, ECO:0000269|PubMed:20705812, ECO:0000269|PubMed:20929775}.
uniprot
proteins
mass_dalton
88495
uniprot
proteins
mutagenesis
MUTAGEN 492; /note="E->A: Markedly reduced affinity for histone H3 and reduced histone H3 phosphorylation."; /evidence="ECO:0000269|PubMed:19918049"; MUTAGEN 511; /note="K->A: Strongly reduced enzyme activity."; /evidence="ECO:0000269|PubMed:19918057"; MUTAGEN 651; /note="H->A: Strongly reduced enzyme activity, markedly reduced affinity for histone H3."; /evidence="ECO:0000269|PubMed:19918049, ECO:0000269|PubMed:19918057"; MUTAGEN 707; /note="D->L: Markedly reduced affinity for histone H3 and reduced histone H3 phosphorylation."; /evidence="ECO:0000269|PubMed:19918049"; MUTAGEN 709; /note="D->N: Markedly reduced affinity for histone H3 and reduced histone H3 phosphorylation."; /evidence="ECO:0000269|PubMed:19918049"; MUTAGEN 713; /note="G->F: Markedly reduced affinity for histone H3 and reduced histone H3 phosphorylation."; /evidence="ECO:0000269|PubMed:19918049"; MUTAGEN 716; /note="D->L: Markedly reduced histone H3 phosphorylation."; /evidence="ECO:0000269|PubMed:19918049
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated on both serine and threonine residues (By similarity). Strongly phosphorylated during mitosis but this does not appear to significantly affect its intrinsic kinase activity. Phosphorylation by AURKB is required for full activity toward histone H3 at 'Ser-3' in mitosis. {ECO:0000250, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:21658950}.
uniprot
proteins
protein_family
Haspin subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Ser/Thr protein kinase family
uniprot
proteins
pubmed
11228240
uniprot
proteins
pubmed
11311556
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15681610
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17084365
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19918049
uniprot
proteins
pubmed
19918057
uniprot
proteins
pubmed
20705812
uniprot
proteins
pubmed
20929775
uniprot
proteins
pubmed
21658950
uniprot
proteins
pubmed
21804608
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
798
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15681610}. Chromosome {ECO:0000269|PubMed:15681610}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15681610}. Note=Nuclear during interphase and associates with the chromosomes and spindle apparatus during mitosis.
uniprot
proteins