ADAMTSL1
entrez
92949
canonical
uniprot
Q8N6G6
canonical
ensembl
ENSG00000178031
resolver
ensp
ENSP00000327887
resolver
ensp
ENSP00000369921
resolver
ensp
ENSP00000505591
resolver
genesymbol
ADAMTSL1
resolver
genesymbol_syn
ADAMTSR1
resolver
genesymbol_syn
C9orf94
resolver
hgnc
HGNC:14632
resolver
uniprot
A6PVN1
resolver
uniprot
A8K7E1
resolver
uniprot
Q496M6
resolver
uniprot
Q496M8
resolver
uniprot
Q5T708
resolver
uniprot
Q5VZT8
resolver
uniprot
Q8NAI9
resolver
uniprot
Q96RW4
resolver
uniprot
Q9BXY3
resolver
uniprot_entry
ATL1_HUMAN
resolver
uniprot_sec
A6PVN1
resolver
uniprot_sec
A8K7E1
resolver
uniprot_sec
Q496M6
resolver
uniprot_sec
Q496M8
resolver
uniprot_sec
Q5T708
resolver
uniprot_sec
Q5VZT8
resolver
uniprot_sec
Q8NAI9
resolver
uniprot_sec
Q96RW4
resolver
uniprot_sec
Q9BXY3
resolver
amino_acid_sequence
MECCRRATPGTLLLFLAFLLLSSRTARSEEDRDGLWDAWGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHNDVKHHGQFYEWLPVSNDPDNPCSLKCQAKGTTLVVELAPKVLDGTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPCMLATCARPGRPSTKHSPHIAAARKVYIQTRRQRKLHFVVGGFAYLLPKTAVVLRCPARRVRKPLITWEKDGQHLISSTHVTVAPFGYLKIHRLKPSDAGVYTCSAGPAREHFVIKLIGGNRKLVARPLSPRSEEEVLAGRKGGPKEALQTHKHQNGIFSNGSKAEKRGLAANPGSRYDDLVSRLLEQGGWPGELLASWEAQDSAERNTTSEEDPGAEQVLLHLPFTMVTEQRRLDDILGNLSQQPEELRDLYSKHLVAQLAQEIFRSHLEHQDTLLKPSERRTSPVTLSPHKHVSGFSSSLRTSSTGDAGGGSRRPHRKPTILRKISAAQQLSASEVVTHLGQTVALASGTLSVLLHCEAIGHPRPTISWARNGEEVQFSDRILLQPDDSLQILAPVEADVGFYTCNATNALGYDSVSIAVTLAGKPLVKTSRMTVINTEKPAVTVDIGSTIKTVQGVNVTINCQVAGVPEAEVTWFRNKSKLGSPHHLHEGSLLLTNVSSSDQGLYSCRAANLHGELTESTQLLILDPPQVPTQLEDIRALLAATGPNLPSVLTSPLGTQLVLDPGNSALLGCPIKGHPVPNITWFHGGQPIVTATGLTHHILAAGQILQVANLSGGSQGEFSCLAQNEAGVLMQKASLVIQDYWWSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITPCENMECRDTTRYCEKVKQLKLCQLSQFKSRCCGTCGKA
uniprot
proteins
mass_dalton
193409
uniprot
proteins
mutagenesis
MUTAGEN 36; /note="W->A: Small reduction in secretion of ADAMTSL1."; /evidence="ECO:0000269|PubMed:19671700"; MUTAGEN 39; /note="W->A: Significant reduction in secretion of ADAMTSL1."; /evidence="ECO:0000269|PubMed:19671700"; MUTAGEN 39; /note="W->F: Abolishes secretion of ADAMTSL1."; /evidence="ECO:0000269|PubMed:19671700"; MUTAGEN 42; /note="W->A: Modest reduction in secretion of ADAMTSL1."; /evidence="ECO:0000269|PubMed:19671700"; MUTAGEN 42; /note="W->F: Abolishes secretion of ADAMTSL1."; /evidence="ECO:0000269|PubMed:19671700"; MUTAGEN 251; /note="N->Q: Abolishes N-glycosylation. Reduces secretion of ADAMTSL1."; MUTAGEN 312; /note="T->A: Small increase in secretion of ADAMTSL1. About 40% increase in secretion of ADAMTSL1; when associated with A-391. Dramatic increase in secretion of ADAMTSL1; when associated with A-391 and A-451."; MUTAGEN 385; /note="W->A: Significant reduction in secretion of ADAMTSL1."; /evidence="ECO:0000269|PubMed:19671700"; MUTAGEN 385; /note="W->F: No effect on secretion of ADAMTSL1."; /evidence="ECO:0000269|PubMed:19671700"; MUTAGEN 391; /note="S->A: Small increase in secretion of ADAMTSL1. About 40% increase in secretion of ADAMTSL1; when associated with A-312. Dramatic increase in secretion of ADAMTSL1; when associated with A-312 and A-451."; MUTAGEN 445; /note="W->A: Modest reduction in secretion of ADAMTSL1."; /evidence="ECO:0000269|PubMed:19671700"; MUTAGEN 451; /note="T->A: Small increase in secretion of ADAMTSL1. Dramatic increase in secretion of ADAMTSL1; when associated with A-312 and A-391.
uniprot
proteins
post_translational_modification
PTM: C-, N- and O-glycosylated. O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTSL1. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion. {ECO:0000269|PubMed:11805097, ECO:0000269|PubMed:17395588, ECO:0000269|PubMed:19671700}.; PTM: Disulfide bonds are present.
uniprot
proteins
pubmed
11805097
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17395588
uniprot
proteins
pubmed
19671700
uniprot
proteins
sequence_length
1762
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:11805097, ECO:0000269|PubMed:17395588, ECO:0000269|PubMed:19671700}.
uniprot
proteins