Gripap1
entrez
54645
canonical
uniprot
Q8VD04
canonical
ensembl
ENSMUSG00000031153
resolver
ensp
ENSMUSP00000068789
resolver
ensp
ENSMUSP00000099218
resolver
ensp
ENSMUSP00000111339
resolver
ensp
ENSMUSP00000260981
resolver
ensp
ENSMUSP00000260983
resolver
ensp
ENSMUSP00000260985
resolver
ensp
ENSMUSP00000260986
resolver
ensp
ENSMUSP00000260988
resolver
ensp
ENSMUSP00000260994
resolver
ensp
ENSMUSP00000260995
resolver
ensp
ENSMUSP00000260999
resolver
ensp
ENSMUSP00000261000
resolver
ensp
ENSMUSP00000261005
resolver
ensp
ENSMUSP00000261020
resolver
ensp
ENSMUSP00000333715
resolver
enst
ENSMUST00000065932
resolver
enst
ENSMUST00000101694
resolver
enst
ENSMUST00000115675
resolver
genesymbol
Gripap1
resolver
genesymbol_syn
DXImx47e
resolver
genesymbol_syn
Kiaa1167
resolver
uniprot
A2AEW7
resolver
uniprot
A2AEW8
resolver
uniprot
A2AEW9
resolver
uniprot
B7ZNL5
resolver
uniprot
O35693
resolver
uniprot
Q3T9C3
resolver
uniprot
Q69ZP9
resolver
uniprot_entry
A2AEW8_MOUSE
resolver
uniprot_entry
A2AEW9_MOUSE
resolver
uniprot_entry
B7ZNL5_MOUSE
resolver
uniprot_entry
GRAP1_MOUSE
resolver
uniprot_sec
A2AEW7
resolver
uniprot_sec
O35693
resolver
uniprot_sec
Q3T9C3
resolver
uniprot_sec
Q69ZP9
resolver
amino_acid_sequence
MAQALSEEEFQRMQTQLLELRTNNYQLSDELRKNGVELSSLRQKVAYLDKEFSKAQKALSKSKKAQEVEVLLSENEMLQAKLHSQEEDFRLQNSTLMAEFSKLCSQLEQLELENRQLKEGVPGAAGAHVDGELLRLQAENTALQKNMAALQERYGKEAVRPSAVGEGQGDPPGDVLPTPLAPMPLAEVELKWEMEREEKKLLWEQLQGLESSKQAETSRLQEELAKLSEKLKKKQESFCRLQTEKETLFNDSRNKIEELQQRKEADLKAQLARTQKLQQELEAANQSLAELRDQRQGERLEHAAALRALQDQIQTAKTQELNMLREQTSELASELQHRQAEYEELMGQKDDLNSQLQESLRANSRLLEQLQEIGQEKEQLTQDLQEARKSAEKRKVMLDELAMETLQEKSQHKEELGAVRLRHEKELLGVRARYERELRELHEDKKRQEEELRGQIREEKARTRELENLQHTVEELQAQVHSMDGAKGWFERRLKEAEESLQQQQQEQEETLKLCREEHAAELKGKDEELQNVREQLQQAQEERDGHVKTISNLKQEVKDTVDGQRILEKKGSAVLKDLKRQLHLERKRADKLQERLQEILTNSKSRTGLEELVLSEMNSPSRTQTGDSSSVSSFSYREILKEKESSAIPARSLSSSPQAQPPRPAELSDEEVAELFQRLAETQQEKWMLEEKVKHLEVSSASMAEDLCRKSAIIETYVMDSRIDVSVAAGHTDRSGLGSVLRDLVKPGDENLREMNKKLQNMLEEQLTKNMHLHKDMEVLSQEIVRLSKECVGSPDPDLEPGEAN
uniprot
proteins
function
FUNCTION: Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity). {ECO:0000250|UniProtKB:Q9JHZ4}.; FUNCTION: [GRASP-1 C-terminal chain]: Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity (By similarity). {ECO:0000250|UniProtKB:Q4V328}.
uniprot
proteins
mass_dalton
92715
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved by caspase-3. A minor C-terminal proteolytic fragment of 30 kDa is produced. Proteolytic cleavage is required for JNK signaling activation. {ECO:0000250|UniProtKB:Q9JHZ4}.
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20098723
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
806
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000250|UniProtKB:Q9JHZ4}; Peripheral membrane protein {ECO:0000305}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q9JHZ4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JHZ4}. Cell projection, axon {ECO:0000250|UniProtKB:Q9JHZ4}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9JHZ4}. Synapse {ECO:0000250|UniProtKB:Q9JHZ4}. Note=Localizes to recycling endosomal tubules that are emanating from early endosomes. {ECO:0000250|UniProtKB:Q9JHZ4}.
uniprot
proteins