HAS1
entrez
3036
canonical
uniprot
Q92839
canonical
ensembl
ENSG00000105509
resolver
ensp
ENSP00000222115
resolver
ensp
ENSP00000445021
resolver
ensp
ENSP00000660061
resolver
ensp
ENSP00000660062
resolver
enst
ENST00000222115
resolver
enst
ENST00000540069
resolver
genesymbol
HAS1
resolver
genesymbol_syn
HAS
resolver
hgnc
HGNC:4818
resolver
uniprot
D2N2G5
resolver
uniprot
G3V1S7
resolver
uniprot
Q14470
resolver
uniprot
Q8IYH3
resolver
uniprot
Q9NS49
resolver
uniprot_entry
D2N2G5_HUMAN
resolver
uniprot_entry
HYAS1_HUMAN
resolver
uniprot_entry
Q8IYH3_HUMAN
resolver
uniprot_sec
G3V1S7
resolver
uniprot_sec
Q14470
resolver
uniprot_sec
Q9NS49
resolver
amino_acid_sequence
MRQDAPKPTPAACRCSGLARRVLTIAFALLILGLMTWAYAAGVPLASDRYGLLAFGLYGAFLSAHLVAQSLFAYLEHRRVAAAARGPLDAATARSVALTISAYQEDPAYLRQCLASARALLYPRARLRVLMVVDGNRAEDLYMVDMFREVFADEDPATYVWDGNYHQPWEPAAAGAVGAGAYREVEAEDPGRLAVEALVRTRRCVCVAQRWGGKREVMYTAFKALGDSVDYVQVCDSDTRLDPMALLELVRVLDEDPRVGAVGGDVRILNPLDSWVSFLSSLRYWVAFNVERACQSYFHCVSCISGPLGLYRNNLLQQFLEAWYNQKFLGTHCTFGDDRHLTNRMLSMGYATKYTSRSRCYSETPSSFLRWLSQQTRWSKSYFREWLYNALWWHRHHAWMTYEAVVSGLFPFFVAATVLRLFYAGRPWALLWVLLCVQGVALAKAAFAAWLRGCLRMVLLSLYAPLYMCGLLPAKFLALVTMNQSGWGTSGRRKLAANYVPLLPLALWALLLLGGLVRSVAHEARADWSGPSRAAEAYHLAAGAGAYVGYWVAMLTLYWVGVRRLCRRRTGGYRVQV
uniprot
proteins
ec_number
2.4.1.212
uniprot
proteins
function
FUNCTION: Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential for the synthesis of hyaluronan, a major component of most extracellular matrices that has a structural role in tissue architecture and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate (By similarity). {ECO:0000250|UniProtKB:Q61647}.
uniprot
proteins
mass_dalton
64704
uniprot
proteins
pathway_participation
PATHWAY: Glycan biosynthesis; hyaluronan biosynthesis. {ECO:0000250|UniProtKB:Q61647}.
uniprot
proteins
protein_family
NodC/HAS family
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
8651928
uniprot
proteins
pubmed
8798544
uniprot
proteins
sequence_length
577
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..45; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 52..72; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 399..419; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 430..450; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 457..477; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 497..517; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 540..560; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins