Naprt
entrez
315085
canonical
uniprot
Q6XQN1
canonical
ensembl
ENSRNOG00000007939
resolver
ensp
ENSRNOP00000010637
resolver
enst
ENSRNOT00000010637
resolver
genesymbol
Naprt
resolver
genesymbol_syn
Naprt1
resolver
uniprot
G3V709
resolver
uniprot_entry
G3V709_RAT
resolver
uniprot_entry
PNCB_RAT
resolver
amino_acid_sequence
MEMELDDQGRMVVRPLLTDLYQATMGLGYWRAGRACEEAEFELFFRHCPFGGSFALTAGLQDCIRFLRAFRLRDADVQFLASVLPPDTDPAFFEHLRALDCSRVSVRALPEGSLAFPGVPLLQVSGPLLLVQLLETPLLCLVSYASLVATNAARLRLIAGPDKRLLEMGLRRAQGPDGGFTASIYSYLGGFDSSSNTLAGQLRGVPVAGTLAHSFITSFLGSEVPPDPMLAPASSEGPAVDLPASVNLWLKHVCIYLGLEEREPHLGERAAFVAYALAFPRAFQGLLDSYSVRRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAKEIRGIFRTVGAEFQMPWLEFVPIAVSNNIDEKELARLAQKGSEVNVIGIGTNVVTCPKQPSMGCVYKLVSVGGQPRIKLTEESQKETLPGSKAAFRFLVSEGSLLLDLLQLAEEPPPKAGQELRVWLQGAQEPCTVKPAQVEPLLRLYLQQGQPYEPLPSLEESRAFAQQSLSRLRPAHKQLQNPAVYQVALSEKLRALVDSLSARGAL
uniprot
proteins
ec_number
6.3.4.21
uniprot
proteins
function
FUNCTION: Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Helps prevent cellular oxidative stress via its role in NAD biosynthesis. {ECO:0000250|UniProtKB:Q6XQN6}.
uniprot
proteins
mass_dalton
58565
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. {ECO:0000250|UniProtKB:Q6XQN6}.
uniprot
proteins
post_translational_modification
PTM: Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. {ECO:0000250|UniProtKB:P22253}.
uniprot
proteins
protein_family
NAPRTase family
uniprot
proteins
sequence_length
538
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q6XQN6}.
uniprot
proteins