PHLDB2
entrez
90102
canonical
uniprot
Q86SQ0
canonical
ensembl
ENSG00000144824
resolver
ensp
ENSP00000377500
resolver
ensp
ENSP00000377502
resolver
ensp
ENSP00000405292
resolver
ensp
ENSP00000405405
resolver
genesymbol
PHLDB2
resolver
genesymbol_syn
LL5B
resolver
hgnc
HGNC:29573
resolver
uniprot
A5PKZ3
resolver
uniprot
Q59EA8
resolver
uniprot
Q68CY3
resolver
uniprot
Q6NT98
resolver
uniprot
Q8N8U8
resolver
uniprot
Q8NAB1
resolver
uniprot
Q8NCU5
resolver
uniprot_entry
PHLB2_HUMAN
resolver
uniprot_sec
A5PKZ3
resolver
uniprot_sec
Q59EA8
resolver
uniprot_sec
Q68CY3
resolver
uniprot_sec
Q6NT98
resolver
uniprot_sec
Q8N8U8
resolver
uniprot_sec
Q8NAB1
resolver
uniprot_sec
Q8NCU5
resolver
amino_acid_sequence
MEEHSYIQKELDLQNGSLEEDSVVHSVENDSQNMMESLSPKKYSSSLRFKANGDYSGSYLTLSQPVPAKRSPSPLGTSVRSSPSLAKIQGSKQFSYDGTDKNIPMKPPTPLLNTTSSLSGYPLGRADFDHYTGRDSERALRLSEKPPYSKYSSRHKSHDNVYSLGGLEGRKASGSLLAMWNGSSLSDAGPPPISRSGAASMPSSPKQARKMSIQDSLALQPKLTRHKELASENINLRTRKYSSSSLSHMGAYSRSLPRLYRATENQLTPLSLPPRNSLGNSKRTKLGEKDLPHSVIDNDNYLNFSSLSSGALPYKTSASEGNPYVSSTLSVPASPRVARKMLLASTSSCASDDFDQASYVGTNPSHSLLAGESDRVFATRRNFSCGSVEFDEADLESLRQASGTPQPALRERKSSISSISGRDDLMDYHRRQREERLREQEMERLERQRLETILSLCAEYTKPDSRLSTGTTVEDVQKINKELEKLQLSDEESVFEEALMSPDTRYRCHRKDSLPDADLASCGSLSQSSASFFTPRSTRNDELLSDLTRTPPPPSSTFPKASSESSYLSILPKTPEGISEEQRSQELAAMEETRIVILNNLEELKQKIKDINDQMDESFRELDMECALLDGEQKSETTELMKEKEILDHLNRKIAELEKNIVGEKTKEKVKLDAEREKLERLQELYSEQKTQLDNCPESMREQLQQQLKRDADLLDVESKHFEDLEFQQLEHESRLDEEKENLTQQLLREVAEYQRNIVSRKEKISALKKQANHIVQQAQREQDHFVKEKNNLIMMLQREKENLCNLEKKYSSLSGGKGFPVNPNTLKEGYISVNEINEPCGNSTNLSPSTQFPADADAVATEPATAVLASQPQSKEHFRSLEERKKQHKEGLYLSDTLPRKKTTSSISPHFSSATMGRSITPKAHLPLGQSNSCGSVLPPSLAAMAKDSESRRMLRGYNHQQMSEGHRQKSEFYNRTASESNVYLNSFHYPDHSYKDQAFDTLSLDSSDSMETSISACSPDNISSASTSNIARIEEMERLLKQAHAEKTRLLESREREMEAKKRALEEEKRRREILEKRLQEETSQRQKLIEKEVKIRERQRAQARPLTRYLPVRKEDFDLRSHVETAGHNIDTCYHVSITEKTCRGFLIKMGGKIKTWKKRWFVFDRNKRTFSYYADKHETKLKGVIYFQAIEEVYYDHLKNANKSPNPLLTFSVKTHDRIYYMVAPSPEAMRIWMDVIVTGAEGYTHFLL
uniprot
proteins
function
FUNCTION: Seems to be involved in the assembly of the postsynaptic apparatus. May play a role in acetyl-choline receptor (AChR) aggregation in the postsynaptic membrane (By similarity). {ECO:0000250, ECO:0000269|PubMed:12376540}.
uniprot
proteins
mass_dalton
142158
uniprot
proteins
mutagenesis
MUTAGEN 1162..1163; /note="KR->AA: Loss of binding to PtdIns(3,4,5)P3."; /evidence="ECO:0000269|PubMed:12376540
uniprot
proteins
pubmed
11001876
uniprot
proteins
pubmed
12376540
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23525008
uniprot
proteins
pubmed
24120883
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27410476
uniprot
proteins
sequence_length
1253
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12376540}. Cytoplasm, cell cortex {ECO:0000269|PubMed:24120883}. Membrane {ECO:0000269|PubMed:12376540}; Peripheral membrane protein {ECO:0000269|PubMed:12376540}. Cell projection, podosome {ECO:0000250|UniProtKB:Q8K1N2}. Note=Translocates to the plasma membrane at high levels of PtdIns(3,4,5)P3. At low levels of PtdIns(3,4,5)P3 is translocated to vesicular compartments. Localized to the myotube podosome cortex that surrounds the core (By similarity). {ECO:0000250|UniProtKB:Q8K1N2}.
uniprot
proteins