Arfgap2
entrez
77038
canonical
uniprot
Q99K28
canonical
ensembl
ENSMUSG00000027255
resolver
ensp
ENSMUSP00000028691
resolver
ensp
ENSMUSP00000078920
resolver
genesymbol
Arfgap2
resolver
genesymbol_syn
Zfp289
resolver
genesymbol_syn
Znf289
resolver
uniprot
Q3UR67
resolver
uniprot
Q9D758
resolver
uniprot
Q9JIH1
resolver
uniprot_entry
ARFG2_MOUSE
resolver
uniprot_entry
Q3UR67_MOUSE
resolver
uniprot_sec
Q9D758
resolver
uniprot_sec
Q9JIH1
resolver
amino_acid_sequence
MAASPSKTEIQTIFKRLRAIPTNKACFDCGAKSPSWASITYGVFLCIDCSGVHRSLGVHLSFIRSTELDSNWSWLQLRCMQVGGNANATAFFRQHGCMANDANTKYTSRAAQMYREKIRQLGSAALTRHGTDLWIDSMNSAPSHSPEKKDSDFFTEHTQAPAWDTAATDPSGTQQPALPSESSSLAQPEQGPNTDLLGTSPQASLELKSSIIGKKKPAAAKKGLGAKKGLGAQKVSNQSFTEIERQAQVAEKLREQQAADAKKQAEESMVASMRLAYQELQIDRKKEEKKLQNLEGKKREQAERLGMGLVSRSSISHSVLSEMQMIEQETPLSAKSSRSQLDLFDDVGTFASGPPKYKDNPFSLGETFGSRWDSDAAWGMDRVEEKEPEVTISSIRPISERTASRREVETRSSGLESSEARQKFAGAKAISSDMFFGREVDSEYEARSRLQQLSGSSAISSSDLFGNMDGAHGGGTVSLGNVLPTADIAQFKQGVKSVAGKMAVLANGVMNSLQDRYGSY
uniprot
proteins
function
FUNCTION: GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1), which is essential for COPI vesicle formation and retrograde transport between the Golgi and the endoplasmic reticulum. Hydrolysis of ARF1-bound GTP leads to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes. Promotes the proper assembly of the COPI coat lattice, rather than just acting as a simple curvature-dependent GAP like ARFGAP1. Also acts as a regulator of STING1 activity, both by promoting cytokine secretion in certain cell types and promoting the proton channel activity of STING1 in the trans-Golgi. {ECO:0000250|UniProtKB:Q8N6H7}.
uniprot
proteins
mass_dalton
56598
uniprot
proteins
pubmed
11278321
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
520
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8N6H7}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8N6H7}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8N6H7}. Cytoplasm {ECO:0000250|UniProtKB:Q8N6H7}. Note=Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment. {ECO:0000250|UniProtKB:Q8N6H7}.
uniprot
proteins