LRRC23
entrez
10233
canonical
uniprot
Q53EV4
canonical
ensembl
ENSG00000010626
resolver
ensp
ENSP00000007969
resolver
ensp
ENSP00000317464
resolver
ensp
ENSP00000390932
resolver
genesymbol
LRRC23
resolver
genesymbol_syn
LRPB7
resolver
hgnc
HGNC:19138
resolver
uniprot
A8K8C6
resolver
uniprot
A8K8K2
resolver
uniprot
D3DUT1
resolver
uniprot
Q8N6K6
resolver
uniprot
Q92977
resolver
uniprot
Q99620
resolver
uniprot_entry
A8K8K2_HUMAN
resolver
uniprot_entry
LRC23_HUMAN
resolver
uniprot_sec
A8K8C6
resolver
uniprot_sec
D3DUT1
resolver
uniprot_sec
Q8N6K6
resolver
uniprot_sec
Q92977
resolver
uniprot_sec
Q99620
resolver
amino_acid_sequence
MSDEDDLEDSEPDQDDSEKEEDEKETEEGEDYRKEGEEFPEEWLPTPLTEDMMKEGLSLLCKTGNGLAHAYVKLEVKERDLTDIYLLRSYIHLRYVDISENHLTDLSPLNYLTHLLWLKADGNRLRSAQMNELPYLQIASFAYNQITDTEGISHPRLETLNLKGNSIHMVTGLDPEKLISLHTVELRGNQLESTLGINLPKLKNLYLAQNMLKKVEGLEDLSNLTTLHLRDNQIDTLSGFSREMKSLQYLNLRGNMVANLGELAKLRDLPKLRALVLLDNPCTDETSYRQEALVQMPYLERLDKEFYEEEERAEADVIRQRLKEEKEQEPEPQRDLEPEQSLI
uniprot
proteins
disease_involvement
DISEASE: Spermatogenic failure 92 (SPGF92) [MIM:620848]: An autosomal recessive, male infertility disorder characterized by asthenozoospermia and defects of the radial spokes and doublet microtubules of sperm flagellum observed by ultrastructural analysis. {ECO:0000269|PubMed:37804054, ECO:0000269|PubMed:38091523}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Essential for sperm motility and male fertility. Plays an important role in the proper assembly of the third radial spoke (RS3) head and the bridge structure between RS2 and RS3 in the sperm flagella. {ECO:0000269|PubMed:37804054, ECO:0000269|PubMed:38091523}.
uniprot
proteins
mass_dalton
39761
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
31429579
uniprot
proteins
pubmed
37804054
uniprot
proteins
pubmed
38091523
uniprot
proteins
pubmed
9074930
uniprot
proteins
sequence_length
343
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000269|PubMed:37804054}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:O35125}. Cytoplasm {ECO:0000269|PubMed:31429579}. Note=Within the sperm flagellum, may be associated with the head of radial spoke 3. {ECO:0000305|PubMed:38091523}.
uniprot
proteins