CYP4B1
entrez
1580
canonical
uniprot
P13584
canonical
ensembl
ENSG00000142973
resolver
ensp
ENSP00000271153
resolver
ensp
ENSP00000360987
resolver
ensp
ENSP00000360991
resolver
ensp
ENSP00000611002
resolver
ensp
ENSP00000611007
resolver
enst
ENST00000371919
resolver
genesymbol
CYP4B1
resolver
hgnc
HGNC:2644
resolver
uniprot
B4DV41
resolver
uniprot
F6TRI2
resolver
uniprot
Q1HBI2
resolver
uniprot
Q8IZB0
resolver
uniprot
Q8TD85
resolver
uniprot
Q8WWF2
resolver
uniprot
Q8WWU9
resolver
uniprot
Q8WWV0
resolver
uniprot_entry
B4DV41_HUMAN
resolver
uniprot_entry
CP4B1_HUMAN
resolver
uniprot_entry
F6TRI2_HUMAN
resolver
uniprot_entry
Q8IZB0_HUMAN
resolver
uniprot_sec
Q1HBI2
resolver
uniprot_sec
Q8TD85
resolver
uniprot_sec
Q8WWF2
resolver
uniprot_sec
Q8WWU9
resolver
uniprot_sec
Q8WWV0
resolver
amino_acid_sequence
MVPSFLSLSFSSLGLWASGLILVLGFLKLIHLLLRRQTLAKAMDKFPGPPTHWLFGHALEIQETGSLDKVVSWAHQFPYAHPLWFGQFIGFLNIYEPDYAKAVYSRGDPKAPDVYDFFLQWIGRGLLVLEGPKWLQHRKLLTPGFHYDVLKPYVAVFTESTRIMLDKWEEKAREGKSFDIFCDVGHMALNTLMKCTFGRGDTGLGHRDSSYYLAVSDLTLLMQQRLVSFQYHNDFIYWLTPHGRRFLRACQVAHDHTDQVIRERKAALQDEKVRKKIQNRRHLDFLDILLGARDEDDIKLSDADLRAEVDTFMFEGHDTTTSGISWFLYCMALYPEHQHRCREEVREILGDQDFFQWDDLGKMTYLTMCIKESFRLYPPVPQVYRQLSKPVTFVDGRSLPAGSLISMHIYALHRNSAVWPDPEVFDSLRFSTENASKRHPFAFMPFSAGPRNCIGQQFAMSEMKVVTAMCLLRFEFSLDPSRLPIKMPQLVLRSKNGFHLHLKPLGPGSGK
uniprot
proteins
ec_number
1.14.14.1
uniprot
proteins
function
FUNCTION: Catalyzes the omega- and (omega-1)-hydroxylation of saturated fatty acids and n-alkanes (By similarity). Also bioactivates xenobiotics such as the procarcinogen 3-methoxy-4-aminoazobenzene and the cyclic arylamines 2-aminofluorene and 2-aminoanthracene (By similarity). In addition, catalyzes O-dealkylation of 7-ethoxycoumarin (By similarity). Functions at the interface of xenobiotic and endobiotic metabolism, contributing both to fatty acid and hydrocarbon oxidation and to the bioactivation of diverse xenobiotics. Preferentially hydroxylates the terminal carbon (omega-hydroxylation) of medium-chain fatty acids (C8-C10), with regioselectivity decreasing as chain length increases. C8 fatty acids and C7 n-alkanes display optimal chain length for regioselective omega-hydroxylation, and n-alkanes (C7-C10) are generally turned over faster and with higher regioselectivity than the corresponding fatty acids. In addition to omega/omega-1 hydroxylation, also catalyzes alpha-, beta-, gamma- and delta-hydroxylation of mid-chain length fatty acids, whereas fatty alcohols of the same chain length are almost exclusively hydroxylated at the omega, omega-1 and omega-2 positions (By similarity). {ECO:0000250|UniProtKB:P15128, ECO:0000250|UniProtKB:P15129, ECO:0000250|UniProtKB:Q64462}.
uniprot
proteins
mass_dalton
58991
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
12142726
uniprot
proteins
pubmed
12695542
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
2298205
uniprot
proteins
pubmed
2574990
uniprot
proteins
sequence_length
511
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P15128}; Peripheral membrane protein {ECO:0000250|UniProtKB:P15128}. Microsome membrane {ECO:0000250|UniProtKB:P15128}; Peripheral membrane protein {ECO:0000250|UniProtKB:P15128}.
uniprot
proteins