ANO3
entrez
63982
canonical
uniprot
Q9BYT9
canonical
ensembl
ENSG00000134343
resolver
ensp
ENSP00000256737
resolver
ensp
ENSP00000432394
resolver
ensp
ENSP00000500506
resolver
enst
ENST00000672621
resolver
genesymbol
ANO3
resolver
genesymbol_syn
C11orf25
resolver
genesymbol_syn
TMEM16C
resolver
hgnc
HGNC:14004
resolver
uniprot
A0A5F9ZHL6
resolver
uniprot
B7Z3F5
resolver
uniprot
B7Z9B9
resolver
uniprot_entry
A0A5F9ZHL6_HUMAN
resolver
uniprot_entry
ANO3_HUMAN
resolver
uniprot_entry
B7Z9B9_HUMAN
resolver
uniprot_sec
B7Z3F5
resolver
amino_acid_sequence
MVHHSGSIQSFKQQKGMNISKSEITKETSLKPSRRSLPCLAQSYAYSKSLSQSTSLFQSTESESQAPTSITLISTDKAEQVNTEENKNDSVLRCSFADLSDFCLALGKDKDYTDESEHATYDRSRLINDFVIKDKSEFKTKLSKNDMNYIASSGPLFKDGKKRIDYILVYRKTNIQYDKRNTFEKNLRAEGLMLEKEPAIASPDIMFIKIHIPWDTLCKYAERLNIRMPFRKKCYYTDGRSKSMGRMQTYFRRIKNWMAQNPMVLDKSAFPDLEESDCYTGPFSRARIHHFIINNKDTFFSNATRSRIVYHMLERTKYENGISKVGIRKLINNGSYIAAFPPHEGAYKSSQPIKTHGPQNNRHLLYERWARWGMWYKHQPLDLIRLYFGEKIGLYFAWLGWYTGMLIPAAIVGLCVFFYGLFTMNNSQVSQEICKATEVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSILTYTWDLIEWEEEEETLRPQFEAKYYKMEIVNPITGKPEPHQPSSDKVTRLLVSVSGIFFMISLVITAVFGVVVYRLVVMEQFASFKWNFIKQYWQFATSAAAVCINFIIIMLLNLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGHPGKYNKLFDRWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLIQNWWSRHKIKRGIHDASIPQWENDWNLQPMNLHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYKFVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYKYGPCANHVEPSENCLKGYVNNSLSFFDLSELGMGKSGYCRYRDYRGPPWSSKPYEFTLQYWHILAARLAFIIVFEHLVFGIKSFIAYLIPDVPKGLHDRIRREKYLVQEMMYEAELEHLQQQRRKSGQPVHHEWP
uniprot
proteins
disease_involvement
DISEASE: Dystonia 24 (DYT24) [MIM:615034]: A form of dystonia, a disorder defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYT24 is an autosomal dominant focal dystonia affecting the neck, laryngeal muscles, and muscles of the upper limbs. {ECO:0000269|PubMed:23200863}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide (By similarity). Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:21984732). {ECO:0000250|UniProtKB:A2AHL1, ECO:0000303|PubMed:21984732}.
uniprot
proteins
mass_dalton
114657
uniprot
proteins
protein_family
Anoctamin family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
21607626
uniprot
proteins
pubmed
21642943
uniprot
proteins
pubmed
21984732
uniprot
proteins
pubmed
22302790
uniprot
proteins
pubmed
23200863
uniprot
proteins
sequence_length
981
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Shows an intracellular localization. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 404..424; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 470..490; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 551..571; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 593..613; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 641..661; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 762..782; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 811..831; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 915..935; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins