Dcst1
entrez
77772
canonical
uniprot
Q059Y8
canonical
ensembl
ENSMUSG00000042672
resolver
ensp
ENSMUSP00000065502
resolver
enst
ENSMUST00000070820
resolver
genesymbol
Dcst1
resolver
uniprot_entry
DCST1_MOUSE
resolver
amino_acid_sequence
MAFLSSTLHSLGIFEKISRIKEVLKNRLLDLTKRRDQAREQQRKRPHTIIQGLLLWSLPVSWIRFLWRQPGEFPVTAFLLGAGTGGLLAIGLFQLLVNPMNIYEEQKVVALYCLASLGAIGWGTSPHIRCASLLLVPKMLGKEGRLFVMGYALAAIYSGPAANLRSNINEVIASLGCTVELQINNTRSAWRVSTAPLRAVFKGMVGSKDSLNKEIQNVSTSFEEMDEQVKSDAGYSSEDWDKNRESTEMFGTSRVRPYLSTQMVYELRTRLRCIHVVNKAILSCYRWFDKKHKNCMRRIHLPLFNNMICVPMKFKFLCNIAKVIEIWCYKRIPVEGNFGQTYDSVNQSIHGLSGEFSANINLKEEKQSSMVGLNTTNWEHMGTEVRDYVRQQETYLQWAMGLLHVLLSCTFLLVFHSAFSYMDHYNWDIRFDNIYISTYFCQIDARRKKLGKQSLLPLRKAERKTVIFPFKATIQAWEMRYVIRELLETLPIVLLLLVLCAIDWALYSVFDTIRQHSFVQYSFRSSHKLEIKVEGDSILAKLLRKTIGALNTSSSTDVETNNMPCLPQPISLNARDYFKASLPTLLLVCLCLAQAFGYRLRRVIAAFYFPKREKKRALFFYNEFLKKRSAFTKLRRAAIVRRANQQKAPPHYLVEALYRRCPLLHRFMRQRCVVCQAMETPDSYVCPTPDCKALYCRSCWDDMQRLCPVCTPREELSSSAHSDSNDDAVYGD
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteasomal degradation thereby negatively regulating type-I-interferon signaling. {ECO:0000250|UniProtKB:Q5T197}.; FUNCTION: Essential sperm cell-surface protein required for sperm-egg fusion and fertilization. {ECO:0000269|PubMed:33871360, ECO:0000269|PubMed:35393517}.
uniprot
proteins
mass_dalton
84332
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q5T197}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
33871360
uniprot
proteins
pubmed
35393517
uniprot
proteins
sequence_length
732
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5T197}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5T197}. Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000305|PubMed:35393517}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes in the anterior acrosome before the acrosome reaction and then translocates to the equatorial segment in acrosome-reacted sperm. {ECO:0000305|PubMed:35393517}.
uniprot
proteins
transmembrane_region
TRANSMEM 47..67; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 77..97; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 108..128; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 395..415; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 490..510; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 577..597; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins