ANAPC15
entrez
25906
canonical
uniprot
P60006
canonical
ensembl
ENSG00000110200
resolver
ensp
ENSP00000227618
resolver
ensp
ENSP00000437360
resolver
ensp
ENSP00000437683
resolver
ensp
ENSP00000439403
resolver
ensp
ENSP00000440002
resolver
ensp
ENSP00000440983
resolver
ensp
ENSP00000441774
resolver
ensp
ENSP00000443383
resolver
ensp
ENSP00000443645
resolver
ensp
ENSP00000443911
resolver
ensp
ENSP00000446383
resolver
ensp
ENSP00000446412
resolver
ensp
ENSP00000534928
resolver
ensp
ENSP00000534929
resolver
ensp
ENSP00000534931
resolver
ensp
ENSP00000534932
resolver
ensp
ENSP00000534934
resolver
ensp
ENSP00000534935
resolver
ensp
ENSP00000534937
resolver
ensp
ENSP00000534938
resolver
ensp
ENSP00000534940
resolver
ensp
ENSP00000534941
resolver
ensp
ENSP00000534943
resolver
ensp
ENSP00000534944
resolver
ensp
ENSP00000534945
resolver
ensp
ENSP00000534948
resolver
ensp
ENSP00000534949
resolver
ensp
ENSP00000534950
resolver
ensp
ENSP00000534951
resolver
ensp
ENSP00000609331
resolver
ensp
ENSP00000609333
resolver
ensp
ENSP00000647732
resolver
ensp
ENSP00000681632
resolver
ensp
ENSP00000734238
resolver
enst
ENST00000502597
resolver
enst
ENST00000543050
resolver
genesymbol
ANAPC15
resolver
genesymbol_syn
C11orf51
resolver
hgnc
HGNC:24531
resolver
uniprot
F5GWM6
resolver
uniprot
G3V1Q3
resolver
uniprot
G5EA39
resolver
uniprot
Q9CXK2
resolver
uniprot
Q9Y269
resolver
uniprot_entry
APC15_HUMAN
resolver
uniprot_entry
F5GWM6_HUMAN
resolver
uniprot_entry
G5EA39_HUMAN
resolver
uniprot_sec
G3V1Q3
resolver
uniprot_sec
Q9CXK2
resolver
uniprot_sec
Q9Y269
resolver
amino_acid_sequence
MSTLFPSLFPRVTETLWFNLDRPCVEETELQQQEQQHQAWLQSIAEKDNNLVPIGKPASEHYDDEEEEDDEDDEDSEEDSEDDEDMQDMDEMNDYNESPDDGEVNEVDMEGNEQDQDQWMI
uniprot
proteins
function
FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (PubMed:21926987, PubMed:27120157, PubMed:27509861). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:29033132). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (PubMed:27120157, PubMed:27509861). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (PubMed:21926987, PubMed:27509861). Also required for degradation of CDC20 (PubMed:21926987). {ECO:0000269|PubMed:21926987, ECO:0000269|PubMed:27120157, ECO:0000269|PubMed:27509861, ECO:0000269|PubMed:29033132}.
uniprot
proteins
mass_dalton
14281
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:29033132}.
uniprot
proteins
protein_family
APC15 family
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
21926987
uniprot
proteins
pubmed
25043029
uniprot
proteins
pubmed
26083744
uniprot
proteins
pubmed
27120157
uniprot
proteins
pubmed
27509861
uniprot
proteins
pubmed
29033132
uniprot
proteins
sequence_length
121
uniprot
proteins