Lgr5
entrez
299802
canonical
uniprot
D4AC13
canonical
ensembl
ENSRNOG00000004221
resolver
ensembl
ENSRNOG00055012303
resolver
ensembl
ENSRNOG00060008107
resolver
ensembl
ENSRNOG00065013860
resolver
ensp
ENSRNOP00000005814
resolver
ensp
ENSRNOP00055016913
resolver
ensp
ENSRNOP00060010216
resolver
ensp
ENSRNOP00065017727
resolver
enst
ENSRNOT00000005814
resolver
enst
ENSRNOT00055020940
resolver
enst
ENSRNOT00060013425
resolver
enst
ENSRNOT00065022833
resolver
genesymbol
Lgr5
resolver
uniprot_entry
LGR5_RAT
resolver
amino_acid_sequence
MDTSRVRMLLSLLALLQLVAAGSPPRPDTMPRGCPSYCHCELDGRMLLRVDCSDLGLSELPSNLSVFTSYLDLSMNNISQLPASLLHRLRFLEELRLAGNALTHIPKGAFAGLHSLKVLMLQNNQLRQVPEEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTDVPVQAFRSLSALQAMTLALNKIHHIADHAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTAIKTLSNLKELGFHSNNIRSIPERAFVGNPSLITIHFYDNPIQFVGISAFQHLPELRTLTLNGASQITEFPDLTGTATLESLTLTGAKISSLPQTVCDQLPNLQVLDLSYNLLEDLPSLSGCQKLQKIDLRHNEIYEIKGGTFQQLFNLRSLNLARNKIAIIHPNAFSTLPSLIKLDLSSNLLSSFPVTGLHGLTHLKLTGNRALQSLIPSANFPELKIIEMPYAYQCCAFGGCENVYKIPNQWNKDDSSSVDDLRKKDAGLFQVQDERDLEDFLLDFEEDLKVLHSVQCSPPPGPFKPCEHLFGSWLIRIGVWTTAVLALSCNALVAFTVFRTPLYISSIKLLIGVIAVVDILMGVSSAILAVVDTFTFGSFAQHGAWWEGGIGCQIVGFLSIFASESSVFLLTLAALERGFSVKCSSKFEMKAPLSSLKAIILLCVLLALTIATVPLLGGSEYNASPLCLPLPFGEPSTTGYMVALVLLNSLCFLIMTIAYTRLYCSLEKGELENLWDCSMVKHTALLLFTNCILYCPVAFLSFSSLLNLTFISPEVIKFILLVIVPLPACLNPLLYIVFNPHFKEDMGSLGKQTRFWTRAKHPSLLSINSDDVEKRSCDSTQALVSFTHASIAYDLPSDSGSSPAYPMTESCHLSSVAFVPCL
uniprot
proteins
function
FUNCTION: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G protein-coupled receptors, does not activate heterotrimeric G proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
99958
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
907
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Rapidly and constitutively internalized to the trans-Golgi network at steady state. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 562..582; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 596..616; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 639..659; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 683..703; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 724..744; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 776..796; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 803..823; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins