Stat5a
entrez
20850
canonical
uniprot
P42230
canonical
ensembl
ENSMUSG00000004043
resolver
ensp
ENSMUSP00000004145
resolver
ensp
ENSMUSP00000102979
resolver
ensp
ENSMUSP00000102980
resolver
ensp
ENSMUSP00000271275
resolver
ensp
ENSMUSP00000271278
resolver
enst
ENSMUST00000004145
resolver
enst
ENSMUST00000107356
resolver
enst
ENSMUST00000107357
resolver
genesymbol
Stat5a
resolver
genesymbol_syn
Mgf
resolver
genesymbol_syn
Mpf
resolver
genesymbol_syn
Stat5A
resolver
uniprot
B2C3G8
resolver
uniprot
F8WIW6
resolver
uniprot
Q3UZ79
resolver
uniprot
Q9JIA0
resolver
uniprot_entry
B2C3G8_MOUSE
resolver
uniprot_entry
F8WIW6_MOUSE
resolver
uniprot_entry
Q3UZ79_MOUSE
resolver
uniprot_entry
Q9JIA0_MOUSE
resolver
uniprot_entry
STA5A_MOUSE
resolver
amino_acid_sequence
MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRGQATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLVREANNCSSPAGVLVDAMSQKHLQINQRFEELRLITQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLGQLNPQERMSRETALQQKQVSLETWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNISSNHLEDYNSMSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPDRNLWNLKPFTTRDFSIRSLADRLGDLNYLIYVFPDRPKDEVFAKYYTPVLAKAVDGYVKPQIKQVVPEFVNASTDAGASATYMDQAPSPVVCPQPHYNMYPPNPDPVLDQDGEFDLDESMDVARHVEELLRRPMDSLDARLSPPAGLFTSARSSLS
uniprot
proteins
function
FUNCTION: Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation. {ECO:0000269|PubMed:10508857, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:7720707}.
uniprot
proteins
mass_dalton
90831
uniprot
proteins
post_translational_modification
PTM: ISGylated. {ECO:0000269|PubMed:22022510}.; PTM: Tyrosine phosphorylated in response to KITLG/SCF, IL2, IL3, IL7, IL15, CSF2/GMCSF, GH1, PRL, EPO and THPO (PubMed:16837552). Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus (PubMed:21135090). Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Tyrosine phosphorylation is required for DNA-binding activity and dimerization (PubMed:7720707). Serine phosphorylation is also required for maximal transcriptional activity (By similarity). Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3 (PubMed:11090077, PubMed:21262971). Alternatively, can be phosphorylated by JAK2 at Tyr-694 (By similarity). {ECO:0000250|UniProtKB:P40763, ECO:0000250|UniProtKB:P42229, ECO:0000250|UniProtKB:Q62771, ECO:0000269|PubMed:11090077, ECO:0000269|PubMed:16837552, ECO:0000269|PubMed:21135090, ECO:0000269|PubMed:21262971, ECO:0000269|PubMed:7720707}.
uniprot
proteins
protein_family
Transcription factor STAT family
uniprot
proteins
pubmed
10508857
uniprot
proteins
pubmed
11090077
uniprot
proteins
pubmed
16192273
uniprot
proteins
pubmed
16837552
uniprot
proteins
pubmed
20696842
uniprot
proteins
pubmed
21135090
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21262971
uniprot
proteins
pubmed
22022510
uniprot
proteins
pubmed
7568026
uniprot
proteins
pubmed
7720707
uniprot
proteins
pubmed
9528750
uniprot
proteins
sequence_length
793
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16837552}. Nucleus {ECO:0000269|PubMed:16837552}. Note=Translocated into the nucleus in response to phosphorylation.
uniprot
proteins