Epcam
entrez
17075
canonical
uniprot
Q99JW5
canonical
ensembl
ENSMUSG00000045394
resolver
ensp
ENSMUSP00000061935
resolver
ensp
ENSMUSP00000157040
resolver
enst
ENSMUST00000053577
resolver
enst
ENSMUST00000234623
resolver
genesymbol
Epcam
resolver
genesymbol_syn
Tacstd1
resolver
uniprot
Q61512
resolver
uniprot_entry
EPCAM_MOUSE
resolver
uniprot_sec
Q61512
resolver
amino_acid_sequence
MAGPQALAFGLLLAVVTATLAAAQRDCVCDNYKLATSCSLNEYGECQCTSYGTQNTVICSKLASKCLAMKAEMTHSKSGRRIKPEGAIQNNDGLYDPDCDEQGLFKAKQCNGTATCWCVNTAGVRRTDKDTEITCSERVRTYWIIIELKHKERESPYDHQSLQTALQEAFTSRYKLNQKFIKNIMYENNVITIDLMQNSSQKTQDDVDIADVAYYFEKDVKGESLFHSSKSMDLRVNGEPLDLDPGQTLIYYVDEKAPEFSMQGLTAGIIAVIVVVSLAVIAGIVVLVISTRKKSAKYEKAEIKEMGEIHRELNA
uniprot
proteins
function
FUNCTION: May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
35019
uniprot
proteins
post_translational_modification
PTM: Glycosylation at Asn-198 is crucial for protein stability. {ECO:0000250}.
uniprot
proteins
protein_family
EPCAM family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1729376
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
315
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lateral cell membrane {ECO:0000250|UniProtKB:P16422}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P16422}. Cell junction, tight junction {ECO:0000250|UniProtKB:P16422}. Note=Colocalizes with CLDN7 at the lateral cell membrane and tight junction. {ECO:0000250|UniProtKB:P16422}.
uniprot
proteins
transmembrane_region
TRANSMEM 267..289; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins