E9PTG8
uniprot
E9PTG8
canonical
activity_regulation
ACTIVITY REGULATION: Inhibited by the pyrrole-indolinone inhibitor SU11274 (K00593): intercalates between the ATP-binding Lys-65 and alpha-C glutamate (Glu-81), resulting in a partial disordering of the lysine side chain. Also specifically inhibited by erlotinib. Slightly inhibited by gefitinib (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MAFANFRRILRLSTFEKRKSREYEHVRRDLDPNDVWEILGELGDGAFGKVYKAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYYDGKLWIMIEFCPGGAVDAIMLELDRGLTEPQIQVVCRQMLEALNFLHGKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVLCETMKDAPYDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSTEFRDFLKIALDKNPETRPSAAQLLQHPFVSTVTSNKALRELVAEAKAEVMEEIEDGKEDGSEKDAVSAVPPPVNHTQDSSANGTQPSLNSDKLLQDSSTPLPPSQPQEPVNGPCNQPSGDGSPQNTSPADEVSKNDNGLKVPVPLRKSRPLSVDARIQVTEEKQITDQAENPSSAASKPPKVNQSRPNSSALETLGVETLANGGLELPGSVTPNHSKRASDCSNLSTSESMDYGTSLSADLSLNKETGSLSLKGSKLHNKTLKRTRRFVVDGVEVSITTSKIISEDEKKDEEMRFLRRQELRELRLLQKEEHRNQTQLSTKHELQLEQMHRRFEQEINAKKKFYDVELENLERQQKQQVEKMEQDHSVRRREEAKRIRLEQDRDYARFQEQLKQMKKEVKRSIEKALRKQRQESMRMGQDSHTQKKQRLDRDFVAKQKEDLELAMKKLTAENRREICDKERDCLNKKQELLRDREAALWEMEEHQLQERHQLVKQQLKDQYFLQRHDLLRKHEKEREQMQRYNQRMMEQLKVRQQQEKARLPKIQRSDGKTRMAMYKKSLHINGAGSASEQREKVKQFSQQEEKRQKAERLQQQQKHENQMRDMVAQCESNMNELQQLQNEKCHLLVEHETQKLKALDESHNQSLKEWRDKLRPRKKALEEDLNQKKREQEMFFRLSEEAETRPTTPNRASKFFPYSSGDAS
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidence in vivo (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
111877
uniprot
proteins
post_translational_modification
PTM: Autophosphorylates following homodimerization, leading to activation of the protein. {ECO:0000250}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
protein_family
STE20 subfamily
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
967
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
uniprot
proteins