DHRS2
entrez
10202
canonical
uniprot
Q13268
canonical
ensembl
ENSG00000100867
resolver
ensp
ENSP00000250383
resolver
ensp
ENSP00000344674
resolver
ensp
ENSP00000401213
resolver
ensp
ENSP00000451895
resolver
ensp
ENSP00000567531
resolver
ensp
ENSP00000678005
resolver
genesymbol
DHRS2
resolver
genesymbol_syn
SDR25C1
resolver
hgnc
HGNC:18349
resolver
uniprot
D3DS54
resolver
uniprot
Q53GS4
resolver
uniprot
Q7Z789
resolver
uniprot
Q9H2R2
resolver
uniprot_entry
DHRS2_HUMAN
resolver
uniprot_sec
D3DS54
resolver
uniprot_sec
Q53GS4
resolver
uniprot_sec
Q7Z789
resolver
uniprot_sec
Q9H2R2
resolver
amino_acid_sequence
MLSAVARGYQGWFHPCARLSVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLSQLLPYMENRRGAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRVNCVVPGIIKTDFSKVFHGNESLWKNFKEHHQLQRIGESEDCAGIVSFLCSPDASYVNGENIAVAGYSTRL
uniprot
proteins
ec_number
1.1.1.-
uniprot
proteins
function
FUNCTION: NADPH-dependent oxidoreductase which catalyzes the reduction of dicarbonyl compounds. Displays reductase activity in vitro with 3,4-hexanedione, 2,3-heptanedione and 1-phenyl-1,2-propanedione as substrates (PubMed:16685466). May function as a dicarbonyl reductase in the enzymatic inactivation of reactive carbonyls involved in covalent modification of cellular components (PubMed:16685466). Also displays a minor hydroxysteroid dehydrogenase activity toward bile acids such as ursodeoxycholic acid (UDCA) and isoursodeoxycholic acid (isoUDCA), which makes it unlikely to control hormone levels (PubMed:16685466). Doesn't show any activity in vitro with retinoids and sugars as substrates (PubMed:16685466). Attenuates MDM2-mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21 (PubMed:20547751). Reduces proliferation, migration and invasion of cancer cells and well as the production of ROS in cancer (PubMed:29106393). {ECO:0000269|PubMed:16685466, ECO:0000269|PubMed:20547751, ECO:0000269|PubMed:29106393}.
uniprot
proteins
mass_dalton
29927
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
11944995
uniprot
proteins
pubmed
11997086
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16685466
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
1847869
uniprot
proteins
pubmed
19027726
uniprot
proteins
pubmed
20547751
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
29106393
uniprot
proteins
pubmed
7556196
uniprot
proteins
sequence_length
280
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix. Nucleus. Note=A minor fraction of the protein is translocated from the mitochondria to the nucleus, after cleavage of the targeting signal.
uniprot
proteins