Gbp3
entrez
55932
canonical
uniprot
Q61107
canonical
ensembl
ENSMUSG00000028268
resolver
ensp
ENSMUSP00000029935
resolver
ensp
ENSMUSP00000101828
resolver
ensp
ENSMUSP00000101829
resolver
ensp
ENSMUSP00000191623
resolver
ensp
ENSMUSP00000191625
resolver
enst
ENSMUST00000029935
resolver
enst
ENSMUST00000106221
resolver
enst
ENSMUST00000106222
resolver
genesymbol
Gbp3
resolver
uniprot
Q8VEC5
resolver
uniprot_entry
GBP3_MOUSE
resolver
uniprot_sec
Q8VEC5
resolver
amino_acid_sequence
MEAPICLVENWKNQLTVNLEAIRILEQIAQPLVVVAIVGLYRTGKSYLMNRLAGRNHGFSLGSTVQSETKGIWMWCVPHPTKPTHTLVLLDTEGLGDVEKGDPKNDSWIFALAVLLSSTFVYNSMSTINQQALEQLHFVTELTQLIRAKSSPREDKVKDSSEFVGFFPDFIWAVRDFALELKLNGRPITEDEYLENALKLIQGDNLKVQQSNMTRECIRYFFPVRKCFVFDRPTSDKRLLLQIENVPENQLERNFQVESEKFCSYIFTNGKTKTLRGGVIVTGNRLGTLVQTYVNAINSGTVPCLENAVTTLAQRENSIAVQKAADHYSEQMAQRMRLPTDTLQELLTVHAACEKEAIAVFMEHSFKDDEQEFQKKLVVTIEERKEEFIRQNEAASIRHCQAELERLSESLRKSISCGAFSVPGGHSLYLEARKKIELGYQQVLRKGVKAKEVLKSFLQSQAIMEDSILQSDKALTDGERAIAAERTKKEVAEKELELLRQRQKEQEQVMEAQERSFRENIAKLQEKMESEKEMLLREQEKMLEHKLKVQEELLIEGFREKSDMLKNEISHLREEMERTRRKPSLFGQILDTIGNAFIMILPGAGKLFGVGLKFLGSLSS
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed:24715728, PubMed:24739961). Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product (PubMed:9659399). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (PubMed:24715728, PubMed:24739961). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (PubMed:24715728, PubMed:24739961). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis, such as Gm12250/Irgb10: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (PubMed:24715728, PubMed:24739961). May play a role in erythroid differentiation (PubMed:9659399). {ECO:0000269|PubMed:24715728, ECO:0000269|PubMed:24739961, ECO:0000269|PubMed:9659399}.
uniprot
proteins
mass_dalton
70801
uniprot
proteins
protein_family
GB1 subfamily
uniprot
proteins
protein_family
GB1/RHD3 GTPase family
uniprot
proteins
protein_family
TRAFAC class dynamin-like GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18025219
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24715728
uniprot
proteins
pubmed
24739961
uniprot
proteins
pubmed
9659399
uniprot
proteins
sequence_length
620
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H0R5}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9H0R5}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9H0R5}. Note=Heterodimers with GBP1, GBP2 and GBP5 localize in the compartment of the prenylated GBPs: with GBP1 in a vesicle-like compartment, with GBP2, around the nucleus and with GBP5, at the Golgi apparatus. {ECO:0000250|UniProtKB:Q9H0R5}.
uniprot
proteins