C5ar1
entrez
12273
canonical
uniprot
P30993
canonical
ensembl
ENSMUSG00000049130
resolver
ensp
ENSMUSP00000060003
resolver
ensp
ENSMUSP00000129972
resolver
enst
ENSMUST00000050770
resolver
enst
ENSMUST00000168818
resolver
genesymbol
C5ar1
resolver
genesymbol_syn
C5ar
resolver
genesymbol_syn
C5r1
resolver
uniprot
Q3TZ86
resolver
uniprot_entry
C5AR1_MOUSE
resolver
uniprot_sec
Q3TZ86
resolver
amino_acid_sequence
MDPIDNSSFEINYDHYGTMDPNIPADGIHLPKRQPGDVAALIIYSVVFLVGVPGNALVVWVTAFEARRAVNAIWFLNLAVADLLSCLALPVLFTTVLNHNYWYFDATACIVLPSLILLNMYASILLLATISADRFLLVFKPIWCQKVRGTGLAWMACGVAWVLALLLTIPSFVYREAYKDFYSEHTVCGINYGGGSFPKEKAVAILRLMVGFVLPLLTLNICYTFLLLRTWSRKATRSTKTLKVVMAVVICFFIFWLPYQVTGVMIAWLPPSSPTLKRVEKLNSLCVSLAYINCCVNPIIYVMAGQGFHGRLLRSLPSIIRNALSEDSVGRDSKTFTPSTTDTSTRKSQAV
uniprot
proteins
function
FUNCTION: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a, stimulating chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:37852260). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:37852260). C5AR1 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G alpha proteins and mediates inhibition of adenylate cyclase (PubMed:37852260). The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events (By similarity). {ECO:0000250|UniProtKB:P21730, ECO:0000269|PubMed:37852260}.
uniprot
proteins
mass_dalton
39023
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of the P-X-P-P motif by GRK2 or GRK3 in response to C5a binding promotes association with beta-arrestin (ARRB1 and/or ARRB2), resulting in internalization of the receptor and short-term desensitization to the ligand. {ECO:0000250|UniProtKB:P21730}.; PTM: Sulfation plays a critical role in the association of C5aR with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small a small peptide agonist. {ECO:0000250|UniProtKB:P21730}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
1401897
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16230349
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
37852260
uniprot
proteins
sequence_length
351
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P21730}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P21730}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:P21730}. Note=Phosphorylated C5aR colocalizes with ARRB1 and ARRB2 in cytoplasmic vesicles. {ECO:0000250|UniProtKB:P21730}.
uniprot
proteins
transmembrane_region
TRANSMEM 38..64; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P21730"; TRANSMEM 70..93; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P21730"; TRANSMEM 111..132; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P21730"; TRANSMEM 154..174; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P21730"; TRANSMEM 202..227; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P21730"; TRANSMEM 244..266; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P21730"; TRANSMEM 284..304; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P21730
uniprot
proteins