Neil2
entrez
382913
canonical
uniprot
Q6R2P8
canonical
ensembl
ENSMUSG00000035121
resolver
ensp
ENSMUSP00000045200
resolver
ensp
ENSMUSP00000152963
resolver
enst
ENSMUST00000038229
resolver
enst
ENSMUST00000226002
resolver
genesymbol
Neil2
resolver
genesymbol_syn
Gm1212
resolver
uniprot
A0A286YCF9
resolver
uniprot
G3X969
resolver
uniprot
Q1LZM6
resolver
uniprot_entry
A0A286YCF9_MOUSE
resolver
uniprot_entry
NEIL2_MOUSE
resolver
uniprot_entry
Q1LZM6_MOUSE
resolver
uniprot_sec
G3X969
resolver
activity_regulation
ACTIVITY REGULATION: Acetylation of Lys-50 leads to loss of DNA nicking activity. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MPEGPSVRKFHHLVSPFVGQKVVKTGGSSKKLHPAAFQSLWLQDAQVHGKKLFLRFDPDEEMEPLNSSPQPIQGMWQKEAVDRELALGPSAQEPSAGPSGSGEPVPSRSAETYNLGKIPSADAQRWLEVRFGLFGSIWVNDFSRAKKANKKGDWRDPVPRLVLHFSGGGFLVFYNCQMSWSPPPVIEPTCDILSEKFHRGQALEALSQAQPVCYTLLDQRYFSGLGNIIKNEALYRARIHPLSLGSCLSSSSREALVDHVVEFSKDWLRDKFQGKERHTQIYQKEQCPSGHQVMKETFGPPDGLQRLTWWCPQCQPQLSSKGPQNLPSS
uniprot
proteins
ec_number
3.2.2.-
uniprot
proteins
ec_number
4.2.99.18
uniprot
proteins
function
FUNCTION: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
36834
uniprot
proteins
protein_family
FPG family
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
329
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins