CLEC5A
entrez
23601
canonical
uniprot
Q9NY25
canonical
ensembl
ENSG00000258227
resolver
ensp
ENSP00000446890
resolver
ensp
ENSP00000449999
resolver
ensp
ENSP00000574780
resolver
enst
ENST00000551012
resolver
genesymbol
CLEC5A
resolver
genesymbol_syn
CLECSF5
resolver
genesymbol_syn
MDL1
resolver
hgnc
HGNC:2054
resolver
uniprot
A4D1U7
resolver
uniprot
G3V1V3
resolver
uniprot
Q14DL9
resolver
uniprot
Q52M11
resolver
uniprot
Q9UKQ0
resolver
uniprot_entry
A4D1U7_HUMAN
resolver
uniprot_entry
CLC5A_HUMAN
resolver
uniprot_entry
G3V1V3_HUMAN
resolver
uniprot_entry
Q14DL9_HUMAN
resolver
uniprot_sec
Q52M11
resolver
uniprot_sec
Q9UKQ0
resolver
amino_acid_sequence
MNWHMIISGLIVVVLKVVGMTLFLLYFPQIFNKSNDGFTTTRSYGTVSQIFGSSSPSPNGFITTRSYGTVCPKDWEFYQARCFFLSTSESSWNESRDFCKGKGSTLAIVNTPEKLKFLQDITDAEKYFIGLIYHREEKRWRWINNSVFNGNVTNQNQNFNCATIGLTKTFDAASCDISYRRICEKNAK
uniprot
proteins
function
FUNCTION: Functions as a positive regulator of osteoclastogenesis (By similarity). Cell surface receptor that signals via TYROBP (PubMed:10449773). Regulates inflammatory responses (By similarity). {ECO:0000250|UniProtKB:Q9R007, ECO:0000269|PubMed:10449773}.; FUNCTION: (Microbial infection) Critical macrophage receptor for dengue virus serotypes 1-4 (PubMed:18496526, PubMed:21566123). The binding of dengue virus to CLEC5A triggers signaling through the phosphorylation of TYROBP (PubMed:18496526). This interaction does not result in viral entry, but stimulates pro-inflammatory cytokine release (PubMed:18496526). {ECO:0000269|PubMed:18496526, ECO:0000269|PubMed:21566123}.
uniprot
proteins
mass_dalton
21521
uniprot
proteins
mutagenesis
MUTAGEN 16; /note="K->I: Abolishes interaction with TYROBP."; /evidence="ECO:0000269|PubMed:10449773
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. Contains sialic acid residues. {ECO:0000250|UniProtKB:Q9R007}.
uniprot
proteins
pubmed
10449773
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18496526
uniprot
proteins
pubmed
20212065
uniprot
proteins
pubmed
21566123
uniprot
proteins
sequence_length
188
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21566123}; Single-pass type II membrane protein {ECO:0000269|PubMed:21566123}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..27; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins