Fbxw11
entrez
103583
canonical
uniprot
Q5SRY7
canonical
ensembl
ENSMUSG00000020271
resolver
ensp
ENSMUSP00000075721
resolver
ensp
ENSMUSP00000090893
resolver
ensp
ENSMUSP00000104991
resolver
ensp
ENSMUSP00000320983
resolver
genesymbol
Fbxw11
resolver
genesymbol_syn
Btrcp2
resolver
genesymbol_syn
Fbw1b
resolver
genesymbol_syn
Fbxw1b
resolver
uniprot
Q3TGM9
resolver
uniprot
Q3TLZ8
resolver
uniprot
Q8BY90
resolver
uniprot
Q8K022
resolver
uniprot
Q923H0
resolver
uniprot_entry
FBW1B_MOUSE
resolver
uniprot_sec
Q3TGM9
resolver
uniprot_sec
Q3TLZ8
resolver
uniprot_sec
Q8BY90
resolver
uniprot_sec
Q8K022
resolver
uniprot_sec
Q923H0
resolver
amino_acid_sequence
MEPDSVIEDKTIELMCSVPRSLWLGCANLVESMCALSCLQSMPSVRCLQISNGTSSVIVSRKRPSEGNYQKEKDLCIKYFDQWSESDQVEFVEHLISRMCHYQHGHINSYLKPMLQRDFITALPEQGLDHIAENILSYLDARSLCAAELVCKEWQRVISEGMLWKKLIERMVRTDPLWKGLSERRGWDQYLFKNRPTDGPPNSFYRSLYPKIIQDIETIESNWRCGRHNLQRIQCRSENSKGVYCLQYDDDKIISGLRDNSIKIWDKSSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDFDDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKRIVSGAYDGKIKVWDLQAALDPRAPASTLCLRTLVEHSGRVFRLQFDEFQIISSSHDDTILIWDFLNVPPSAQNETRSPSRTYTYISR
uniprot
proteins
function
FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11896578). Probably recognizes and binds to phosphorylated target proteins: the interaction with substrates requires the phosphorylation of the two serine residues in the substrates' destruction motif D-S-G-X(2,3,4)-S (By similarity). SCF(FBXW11) mediates the ubiquitination of phosphorylated CTNNB1 and participates in Wnt signaling regulation (By similarity). SCF(FBXW11) plays a key role in NF-kappa-B activation by mediating ubiquitination of phosphorylated NFKBIA, leading to its degradation by the proteasome, thereby allowing the associated NF-kappa-B complex to translocate into the nucleus and to activate transcription (PubMed:11896578). The SCF(FBXW11) complex also regulates NF-kappa-B by mediating ubiquitination of phosphorylated NFKB1: specifically ubiquitinates the p105 form of NFKB1, leading to its degradation (By similarity). SCF(FBXW11) mediates the ubiquitination of IFNAR1 (By similarity). SCF(FBXW11) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (By similarity). Involved in the oxidative stress-induced a ubiquitin-mediated decrease in RCAN1 (By similarity). Mediates the degradation of CDC25A induced by ionizing radiation in cells progressing through S phase and thus may function in the intra-S-phase checkpoint (By similarity). Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and phosphorylated PER2 (PubMed:18782782). SCF(FBXW11) mediates the ubiquitination of CYTH1, and probably CYTH2 (By similarity). SCF(FBXW11) acts as a regulator of mTORC1 signaling pathway by catalyzing ubiquitination and subsequent proteasomal degradation of phosphorylated DEPTOR, TFE3 and MITF (By similarity). {ECO:0000250|UniProtKB:Q9UKB1, ECO:0000269|PubMed:11896578, ECO:0000269|PubMed:18782782}.
uniprot
proteins
mass_dalton
62063
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:11896578}.
uniprot
proteins
pubmed
11850814
uniprot
proteins
pubmed
11896578
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15917222
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18782782
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
542
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18782782}. Nucleus {ECO:0000269|PubMed:18782782}.
uniprot
proteins