IFNB1
entrez
3456
canonical
uniprot
P01574
canonical
ensembl
ENSG00000171855
resolver
ensp
ENSP00000369581
resolver
enst
ENST00000380232
resolver
genesymbol
IFNB1
resolver
genesymbol_syn
IFB
resolver
genesymbol_syn
IFNB
resolver
hgnc
HGNC:5434
resolver
uniprot
Q5VWC9
resolver
uniprot_entry
IFNB_HUMAN
resolver
uniprot_sec
Q5VWC9
resolver
amino_acid_sequence
MTNKCLLQIALLLCFSTTALSMSYNLLGFLQRSSNFQCQKLLWQLNGRLEYCLKDRMNFDIPEEIKQLQQFQKEDAALTIYEMLQNIFAIFRQDSSSTGWNETIVENLLANVYHQINHLKTVLEEKLEKEDFTRGKLMSSLHLKRYYGRILHYLKAKEYSHCAWTIVRVEILRNFYFINRLTGYLRN
uniprot
proteins
function
FUNCTION: Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli (PubMed:10049744, PubMed:10556041, PubMed:6157094, PubMed:6171735, PubMed:7665574, PubMed:8027027, PubMed:8969169). Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins (PubMed:10049744, PubMed:10556041, PubMed:7665574, PubMed:8027027, PubMed:8969169). Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways (By similarity). Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor (By similarity). Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss (By similarity). IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth (By similarity). {ECO:0000250|UniProtKB:P01575, ECO:0000269|PubMed:10049744, ECO:0000269|PubMed:10556041, ECO:0000269|PubMed:6157094, ECO:0000269|PubMed:6171735, ECO:0000269|PubMed:7665574, ECO:0000269|PubMed:8027027, ECO:0000269|PubMed:8969169}.
uniprot
proteins
mass_dalton
22294
uniprot
proteins
protein_family
Type-I (or alpha/beta) interferon family
uniprot
proteins
pubmed
10049744
uniprot
proteins
pubmed
10556041
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16593086
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
19054851
uniprot
proteins
pubmed
2414376
uniprot
proteins
pubmed
6157094
uniprot
proteins
pubmed
6157601
uniprot
proteins
pubmed
6159580
uniprot
proteins
pubmed
6159584
uniprot
proteins
pubmed
6159597
uniprot
proteins
pubmed
6162107
uniprot
proteins
pubmed
6164984
uniprot
proteins
pubmed
6171735
uniprot
proteins
pubmed
7665574
uniprot
proteins
pubmed
7813427
uniprot
proteins
pubmed
8027027
uniprot
proteins
pubmed
8469318
uniprot
proteins
pubmed
8469319
uniprot
proteins
pubmed
8798579
uniprot
proteins
pubmed
8969169
uniprot
proteins
pubmed
9342320
uniprot
proteins
pubmed
9345408
uniprot
proteins
sequence_length
187
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:6157094}.
uniprot
proteins