Pno1
entrez
66249
canonical
uniprot
Q9CPS7
canonical
ensembl
ENSMUSG00000020116
resolver
ensp
ENSMUSP00000020317
resolver
enst
ENSMUST00000020317
resolver
genesymbol
Pno1
resolver
uniprot_entry
PNO1_MOUSE
resolver
amino_acid_sequence
METQSTGTEDGFTPVTHRGGRRAKKRQAEQSSAAGQDGEAGRMDTEEARPAKRPVFPPLSGDQLLTGKEETRKIPVPGNRYTPLKENWMKIFTPIVEHLGLQIRFNLKSRNVEIRTCKDTKDVSALTKAADFVKAFVLGFQVEDALALIRLDDLFLESFEITDVKPLKGDHLSRAIGRIAGKGGKTKFTIENVTRTRIVLADVHVHILGSFQNIKMARTAICNLILGNPPSKVYGNIRAVASRSADRF
uniprot
proteins
function
FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Positively regulates dimethylation of two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA. {ECO:0000250|UniProtKB:Q9NRX1}.
uniprot
proteins
mass_dalton
27454
uniprot
proteins
protein_family
PNO1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15497447
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
248
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9NRX1}.
uniprot
proteins