CCL11
entrez
6356
canonical
uniprot
P51671
canonical
ensembl
ENSG00000172156
resolver
ensp
ENSP00000302234
resolver
enst
ENST00000305869
resolver
genesymbol
CCL11
resolver
genesymbol_syn
SCYA11
resolver
hgnc
HGNC:10610
resolver
uniprot
P50877
resolver
uniprot
Q6I9T4
resolver
uniprot
Q92490
resolver
uniprot
Q92491
resolver
uniprot_entry
CCL11_HUMAN
resolver
uniprot_entry
Q6I9T4_HUMAN
resolver
uniprot_sec
P50877
resolver
uniprot_sec
Q92490
resolver
uniprot_sec
Q92491
resolver
amino_acid_sequence
MKVSAALLWLLLIAAAFSPQGLAGPASVPTTCCFNLANRKIPLQRLESYRRITSGKCPQKAVIFKTKLAKDICADPKKKWVQDSMKYLDQKSPTPKP
uniprot
proteins
function
FUNCTION: Chemokine that plays a central role in both allergic and non-allergic inflammatory reactions by inducing the migration of different leukocyte types including eosinophils, basophils, macrophages and dendritic cells (PubMed:8597956, PubMed:33846499). Exerts its effects primarily by binding to the CCR3 receptor (PubMed:8631813). Induces also chemotaxis of endothelial cells and promotes angiogenesis by activating the PI3K/Akt pathway (PubMed:28279120). {ECO:0000269|PubMed:28279120, ECO:0000269|PubMed:33846499, ECO:0000269|PubMed:8597956, ECO:0000269|PubMed:8631813}.
uniprot
proteins
mass_dalton
10732
uniprot
proteins
post_translational_modification
PTM: O-linked glycan consists of a Gal-GalNAc disaccharide which is modified with up to 2 sialic acid residues. {ECO:0000269|PubMed:9578468}.
uniprot
proteins
protein_family
Intercrine beta (chemokine CC) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
28279120
uniprot
proteins
pubmed
33846499
uniprot
proteins
pubmed
8597956
uniprot
proteins
pubmed
8609214
uniprot
proteins
pubmed
8631813
uniprot
proteins
pubmed
8780731
uniprot
proteins
pubmed
9169149
uniprot
proteins
pubmed
9299399
uniprot
proteins
pubmed
9578468
uniprot
proteins
pubmed
9712872
uniprot
proteins
sequence_length
97
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:33846499, ECO:0000305|PubMed:8597956}.
uniprot
proteins