CHTF8
entrez
54921
canonical
uniprot
P0CG13
canonical
ensembl
ENSG00000168802
resolver
ensp
ENSP00000381290
resolver
ensp
ENSP00000408367
resolver
enst
ENST00000398235
resolver
enst
ENST00000448552
resolver
genesymbol
CHTF8
resolver
genesymbol_syn
CTF8
resolver
hgnc
HGNC:24353
resolver
uniprot
A8MYX8
resolver
uniprot
Q71E72
resolver
uniprot
Q8NDH8
resolver
uniprot
Q8WV66
resolver
uniprot
Q9NX73
resolver
uniprot_entry
CTF8_HUMAN
resolver
uniprot_sec
A8MYX8
resolver
uniprot_sec
Q71E72
resolver
uniprot_sec
Q8NDH8
resolver
uniprot_sec
Q8WV66
resolver
uniprot_sec
Q9NX73
resolver
amino_acid_sequence
MVQIVISSARAGGLAEWVLMELQGEIEARYSTGLAGNLLGDLHYTTEGIPVLIVGHHILYGKIIHLEKPFAVLVKHTPGDQDCDELGRETGTRYLVTALIKDKILFKTRPKPIITSVPKKV
uniprot
proteins
function
FUNCTION: Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DSCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates POLH, which is suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with replication fork progression. {ECO:0000269|PubMed:12930902, ECO:0000269|PubMed:17545166}.
uniprot
proteins
mass_dalton
13314
uniprot
proteins
protein_family
CTF8 family
uniprot
proteins
pubmed
12766176
uniprot
proteins
pubmed
12930902
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
17545166
uniprot
proteins
pubmed
22814378
uniprot
proteins
sequence_length
121
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12766176}. Note=Associates with chromatin during S phase. {ECO:0000269|PubMed:12766176}.
uniprot
proteins