Rpusd4
entrez
71989
canonical
uniprot
Q9CWX4
canonical
ensembl
ENSMUSG00000032044
resolver
ensp
ENSMUSP00000034543
resolver
enst
ENSMUST00000034543
resolver
genesymbol
Rpusd4
resolver
uniprot_entry
RUSD4_MOUSE
resolver
amino_acid_sequence
MAAPCLRTPGVQLLSMSSRPGRLFTPGSWSFCSSATSSRPLNAQRLAEKLRAQKQEQKAKEVRVPTNPVQRRVQELVRFTQQLQRVHPNVLAKELSRRILHQDNDLVVINKPYGLPVHGGPGVQLCISDVLPILAKMLHGHKAEPLHLCHRLDKETTGVMVLAWEKDMAHQVQELFRTRQVEKKYWAITVRVPLPSAGVVDIPIKEKEVQGPQQHHKMTLSPSYRLDNGKMVKVRASRDAHVAVTQYQVLSSASSSALVELQPVTGIKHQLRVHLSFGLDCPILGDHKYSDWTRLAPQKLSAGTLKKLGLQQSKARYIPLHLHARQLILPALGSRTEELLLTCKLPHFFARSLLRLGLDMPNQDQSRGNKARHVEAR
uniprot
proteins
ec_number
5.4.99.-
uniprot
proteins
function
FUNCTION: Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates. Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA, controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation. Acts on position 39 in mitochondrial tRNA(Phe). Also catalyzes pseudouridylation of mRNAs in nucleus: acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. {ECO:0000250|UniProtKB:Q96CM3}.
uniprot
proteins
mass_dalton
42407
uniprot
proteins
protein_family
Pseudouridine synthase RluA family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
377
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:Q96CM3}. Nucleus {ECO:0000250|UniProtKB:Q96CM3}. Cytoplasm {ECO:0000250|UniProtKB:Q96CM3}. Note=Mainly localizes to mitochondrion. Localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly. Also found in nucleus and cytoplasm. {ECO:0000250|UniProtKB:Q96CM3}.
uniprot
proteins