Nox4
entrez
85431
canonical
uniprot
Q924V1
canonical
ensembl
ENSRNOG00000013925
resolver
ensembl
ENSRNOG00055019334
resolver
ensembl
ENSRNOG00060020422
resolver
ensembl
ENSRNOG00065028560
resolver
ensp
ENSRNOP00000085650
resolver
ensp
ENSRNOP00000106633
resolver
ensp
ENSRNOP00055026709
resolver
ensp
ENSRNOP00060029150
resolver
ensp
ENSRNOP00065040409
resolver
enst
ENSRNOT00000102096
resolver
enst
ENSRNOT00000131019
resolver
enst
ENSRNOT00055032981
resolver
enst
ENSRNOT00060035466
resolver
enst
ENSRNOT00065049276
resolver
genesymbol
Nox4
resolver
genesymbol_syn
Kox
resolver
uniprot
A0ABK0L8S3
resolver
uniprot
Q99M78
resolver
uniprot_entry
A0ABK0L8S3_RAT
resolver
uniprot_entry
NOX4_RAT
resolver
uniprot_sec
Q99M78
resolver
activity_regulation
ACTIVITY REGULATION: Activated by insulin. Inhibited by diphenylene iodonium. Inhibited by plumbagin. Activated by phorbol 12-myristate 13-acetate (PMA) (By similarity). {ECO:0000250|UniProtKB:Q9JHI8, ECO:0000250|UniProtKB:Q9NPH5}.
uniprot
proteins
amino_acid_sequence
MALSWRSWLANEGVKHLCLLVWLSLNVLLFWKTFLLYNQGPEYYYIHQMLGLGLCLSRASASVLNLNCSLILLPMCRTVLAYLRGSQKVPSRRTRRLLDKSKTLHITCGITICIFSGVHVAAHLVNALNFSVNYSEHFLALNAARYQNEDPRKLLFTTVPGLTGVCMVVVLFLMVTASTYAIRVSNYDIFWYTHNLFFVFYMLLLLHVSGGLLKYQTNLDTHPPGCISLNRTPSQNMSIADYVSEHFHGSLPGGFSKLEDHYQKTLVKICLEEPKFQAHFPQTWIWISGPLCLYCAERLYRCIRSNKPVTIISVINHPSDVMELRMIKENFKARPGQYIILHCPSVSALENHPFTLTMCPTETKATFGVHFKVVGDWTERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEESLNYEVSLCVAGGIGVTPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSFQWFADLLYVLHNKFWQENRPDFVNIQLYLSQTDGIQKIIGEKYHTLNSRLFIGRPRWKLLFDEIAKCNRGKTVGVFCCGPSSISKTLHNLSNRNNSYGTKFEYNKESFS
uniprot
proteins
ec_number
1.6.3.1
uniprot
proteins
function
FUNCTION: NADPH oxidase that catalyzes predominantly the reduction of oxygen to H2O2 (By similarity). Can also catalyze to a smaller extent, the reduction of oxygen to superoxide (PubMed:15322091, PubMed:16135519). May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity (By similarity). May regulate insulin signaling cascade (By similarity). May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB (By similarity). May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation (By similarity). Promotes ferroptosis, reactive oxygen species production and reduced glutathione (GSH) levels by activating NLRP3 inflammasome activation and cytokine release (By similarity). {ECO:0000250|UniProtKB:Q9NPH5, ECO:0000269|PubMed:15322091, ECO:0000269|PubMed:16135519}.
uniprot
proteins
mass_dalton
66469
uniprot
proteins
mutagenesis
MUTAGEN 119; /note="H->L: Loss of interaction with CYBA/p22phox."; /evidence="ECO:0000269|PubMed:15322091
uniprot
proteins
post_translational_modification
PTM: N-glycosylation is required for the function. {ECO:0000250|UniProtKB:Q9NPH5}.
uniprot
proteins
pubmed
11032835
uniprot
proteins
pubmed
11348997
uniprot
proteins
pubmed
14670934
uniprot
proteins
pubmed
15322091
uniprot
proteins
pubmed
16135519
uniprot
proteins
pubmed
16150729
uniprot
proteins
sequence_length
578
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9NPH5}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15322091}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9NPH5}; Multi-pass membrane protein {ECO:0000255}. Cell junction, focal adhesion {ECO:0000269|PubMed:14670934}. Nucleus {ECO:0000250|UniProtKB:Q9NPH5}.
uniprot
proteins
transmembrane_region
TRANSMEM 17..37; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 63..83; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 105..125; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 155..175; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 189..209; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 425..445; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins