Dazap2
entrez
300235
canonical
uniprot
P60486
canonical
ensembl
ENSRNOG00000004628
resolver
ensembl
ENSRNOG00055026630
resolver
ensembl
ENSRNOG00060015232
resolver
ensembl
ENSRNOG00065020794
resolver
ensp
ENSRNOP00000006239
resolver
ensp
ENSRNOP00055037705
resolver
ensp
ENSRNOP00060020908
resolver
ensp
ENSRNOP00065028376
resolver
enst
ENSRNOT00000006239
resolver
enst
ENSRNOT00055045976
resolver
enst
ENSRNOT00060026115
resolver
enst
ENSRNOT00065035264
resolver
genesymbol
Dazap2
resolver
genesymbol_syn
Prtb
resolver
uniprot
A0A0H2UHD1
resolver
uniprot_entry
DAZP2_RAT
resolver
uniprot_sec
A0A0H2UHD1
resolver
amino_acid_sequence
MNSKGQYPTQPTYPVQPPGNPVYPQTLHLPQAPPYTDAPPAYSELYRPSFVHPGAATVPTMSAAFPGASLYLPMAQSVAVGPLGSTIPMAYYPVGPIYPPGSAVLVEGGYDAGARFGAGATTGSIPPPPPGCPPNAAQLAVMQGANVLVTQRKGNFFMGGSDGGYTIW
uniprot
proteins
function
FUNCTION: In unstressed cells, promotes SIAH1-mediated polyubiquitination and degradation of the serine/threonine-protein kinase HIPK2, probably by acting as a loading factor that potentiates complex formation between HIPK2 and ubiquitin ligase SIAH1 (By similarity). In response to DNA damage, localizes to the nucleus following phosphorylation by HIPK2 and modulates the expression of a subset of TP53/p53 target genes by binding to TP53 at target gene promoters (By similarity). This limits the expression of a number of cell death-mediating TP53 target genes, reducing DNA damage-induced cell death (By similarity). Enhances the binding of transcription factor TCF7L2/TCF4, a Wnt signaling pathway effector, to the promoters of target genes (By similarity). Plays a role in stress granule formation (By similarity). {ECO:0000250|UniProtKB:Q15038, ECO:0000250|UniProtKB:Q9DCP9}.
uniprot
proteins
mass_dalton
17292
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by SMURF2, leading to proteasomal degradation. Ubiquitinated by NEDD4, leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q15038}.; PTM: Following DNA damage, phosphorylated by HIPK2 which promotes DAZAP2 localization to the nucleus, reduces interaction of DAZAP2 with HIPK2 and SIAH1, and prevents DAZAP2-dependent ubiquitination of HIPK2 by E3 ubiquitin-protein ligase SIAH1 and subsequent HIPK2 proteasomal degradation. {ECO:0000250|UniProtKB:Q15038}.
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
168
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q15038}. Nucleus {ECO:0000250|UniProtKB:Q15038}. Nucleus speckle {ECO:0000250|UniProtKB:Q15038}. Nucleus, nuclear body {ECO:0000250|UniProtKB:Q15038}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:Q15038}. Note=Predominantly nuclear in macrophages, stimulation of IL17RB with its ligand IL17E induces accumulation in the cytoplasm (By similarity). Predominantly cytoplasmic when unphosphorylated and localizes to the nucleus following phosphorylation by HIPK2 (By similarity). Localizes to stress granules under cellular stress conditions (By similarity). {ECO:0000250|UniProtKB:Q15038}.
uniprot
proteins