Nck1
entrez
17973
canonical
uniprot
Q99M51
canonical
ensembl
ENSMUSG00000032475
resolver
ensp
ENSMUSP00000108495
resolver
ensp
ENSMUSP00000112221
resolver
ensp
ENSMUSP00000170505
resolver
enst
ENSMUST00000112874
resolver
enst
ENSMUST00000116522
resolver
genesymbol
Nck1
resolver
uniprot
F7BWY1
resolver
uniprot
O55032
resolver
uniprot
Q8BH99
resolver
uniprot
Q9Z279
resolver
uniprot_entry
F7BWY1_MOUSE
resolver
uniprot_entry
NCK1_MOUSE
resolver
uniprot_entry
Q8BH99_MOUSE
resolver
uniprot_sec
O55032
resolver
uniprot_sec
Q9Z279
resolver
amino_acid_sequence
MAEEVVVVAKFDYVAQQEQELDIKKNERLWLLDDSKSWWRVRNSMNKTGFVPSNYVERKNSARKASIVKNLKDTLGIGKVKRKPSVPDTASPADDSFVDPGERLYDLNMPAFVKFNYMAEREDELSLIKGTKVIVMEKCSDGWWRGSYNGQIGWFPSNYVTEEGDSPLGDHVGSLSEKLAAVVNNLNTGQVLHVVQALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTIMQNNPLTSGLEPSPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPNDFSVSLKAQGKNKHFKVQLKETVYCIGQRKFSTMEELVEHYKKAPIFTSEQGEKLYLVKHLS
uniprot
proteins
function
FUNCTION: Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. Also acts as an adpater protein for the T cell receptor complex (TCR-CD3E). Upon ligand engagement, is recruited by CD3E and promotes maturation of the immune synapse and T cell activation. {ECO:0000250|UniProtKB:P16333}.
uniprot
proteins
mass_dalton
42891
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser and Tyr residues. Phosphorylated in response to activation of EGFR and FcERI. Phosphorylated by activated PDGFRB. {ECO:0000250|UniProtKB:P16333}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9722576
uniprot
proteins
sequence_length
377
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Nucleus {ECO:0000250}. Note=Mostly cytoplasmic, but shuttles between the cytoplasm and the nucleus. Import into the nucleus requires interaction with SOCS7. Predominantly nuclear following genotoxic stresses, such as UV irradiation, hydroxyurea or mitomycin C treatments (By similarity). {ECO:0000250}.
uniprot
proteins