Cpt1a
entrez
12894
canonical
uniprot
P97742
canonical
ensembl
ENSMUSG00000024900
resolver
ensp
ENSMUSP00000025835
resolver
ensp
ENSMUSP00000166137
resolver
ensp
ENSMUSP00000166143
resolver
ensp
ENSMUSP00000166150
resolver
ensp
ENSMUSP00000166151
resolver
enst
ENSMUST00000025835
resolver
genesymbol
Cpt1a
resolver
genesymbol_syn
Cpt-1
resolver
genesymbol_syn
Cpt1
resolver
uniprot
O35288
resolver
uniprot
Q3UGT1
resolver
uniprot
Q7TQD5
resolver
uniprot
Q80SW3
resolver
uniprot
Q8BP98
resolver
uniprot
Q8C7H8
resolver
uniprot_entry
CPT1A_MOUSE
resolver
uniprot_entry
Q3UGT1_MOUSE
resolver
uniprot_entry
Q7TQD5_MOUSE
resolver
uniprot_sec
O35288
resolver
uniprot_sec
Q80SW3
resolver
uniprot_sec
Q8BP98
resolver
uniprot_sec
Q8C7H8
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by malonyl-CoA. {ECO:0000269|PubMed:16169268}.
uniprot
proteins
amino_acid_sequence
MAEAHQAVAFQFTVTPDGIDLRLSHEALKQICLSGLHSWKKKFIRFKNGIITGVFPASPSSWLIVVVGVISSMHTKVDPSLGMIAKINRTLDTTGRMSSQTKNIVSGVLFGTGLWVAIIMTMRYSLKVLLSYHGWMFAEHGKMSRSTRIWMAMVKVFSGRKPMLYSFQTSLPRLPVPAVKDTVSRYLESVRPLMKEGDFQRMTALAQDFAVNLGPKLQWYLKLKSWWATNYVSDWWEEYIYLRGRGPIMVNSNYYAMEMLYITPTHIQAARAGNTIHAILLYRRTVDREELKPIRLLGSTIPLCSAQWERLFNTSRIPGEETDTIQHVKDSRHIVVYHRGRYFKVWLYHDGRLLRPRELEQQMQQILDDTSEPQPGEAKLAALTAADRVPWAKCRQTYFARGKNKQSLDAVEKAAFFVTLDESEQGYREEDPEASIDSYAKSLLHGRCFDRWFDKSITFVVFKNSKIGINAEHSWADAPIVGHLWEYVMATDVFQLGYSEDGHCKGDKNPNIPKPTRLQWDIPGECQEVIETSLSSASFLANDVDLHSFPFDTFGKGLIKKCRTSPDAFIQLALQLAHYKDMGKFCLTYEASMTRLFREGRTETVRSCTTESCNFVLAMMDPTTTAEQRFKLFKIACEKHQHLYRLAMTGAGIDRHLFCLYVVSKYLAVDSPFLKEVLSEPWRLSTSQTPQQQVELFDFEKYPDYVSCGGGFGPVADDGYGVSYIIVGENFIHFHISSKFSSPETDSHRFGKHLRQAMMDIITLFGLTANSKK
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
ec_number
2.3.1.21
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed:16169268, PubMed:17030509). Plays an important role in hepatic triglyceride metabolism (By similarity). {ECO:0000250|UniProtKB:P32198, ECO:0000269|PubMed:16169268, ECO:0000269|PubMed:17030509}.; FUNCTION: Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion (PubMed:16169268, PubMed:17030509). Also possesses a lysine succinyltransferase activity that can regulate enzymatic activity of substrate proteins such as ENO1 and metabolism independent of its classical carnitine O-palmitoyltransferase activity (By similarity). Plays an important role in hepatic triglyceride metabolism (By similarity). Also plays a role in inducible regulatory T-cell (iTreg) differentiation once activated by butyryl-CoA that antagonizes malonyl-CoA-mediated CPT1A repression (PubMed:34035164). Sustains the IFN-I response by recruiting ZDHCC4 to palmitoylate MAVS at the mitochondria leading to MAVS stabilization and activation (By similarity). Promotes ROS-induced oxidative stress in liver injury via modulation of NFE2L2 and NLRP3-mediated signaling pathways (PubMed:32893669). {ECO:0000250|UniProtKB:P32198, ECO:0000250|UniProtKB:P50416, ECO:0000269|PubMed:16169268, ECO:0000269|PubMed:17030509, ECO:0000269|PubMed:32893669, ECO:0000269|PubMed:34035164}.
uniprot
proteins
mass_dalton
88251
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
uniprot
proteins
protein_family
Carnitine/choline acetyltransferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16169268
uniprot
proteins
pubmed
17030509
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22229081
uniprot
proteins
pubmed
32893669
uniprot
proteins
pubmed
34035164
uniprot
proteins
pubmed
41570820
uniprot
proteins
pubmed
8830050
uniprot
proteins
pubmed
9680378
uniprot
proteins
sequence_length
773
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:P50416}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 48..73; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 103..122; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins