Crtc1
entrez
382056
canonical
uniprot
Q68ED7
canonical
ensembl
ENSMUSG00000003575
resolver
ensp
ENSMUSP00000075916
resolver
ensp
ENSMUSP00000315095
resolver
ensp
ENSMUSP00000315100
resolver
ensp
ENSMUSP00000315102
resolver
ensp
ENSMUSP00000315107
resolver
ensp
ENSMUSP00000315111
resolver
ensp
ENSMUSP00000315114
resolver
enst
ENSMUST00000076615
resolver
genesymbol
Crtc1
resolver
genesymbol_syn
Kiaa0616
resolver
genesymbol_syn
Mect1
resolver
genesymbol_syn
Torc1
resolver
uniprot
Q6ZQ85
resolver
uniprot_entry
CRTC1_MOUSE
resolver
uniprot_sec
Q6ZQ85
resolver
amino_acid_sequence
MATSNNPRKFSEKIALHNQKQAEETAAFEEVMKDLSLTRAARLQLQKSQYLQLGPSRGQYYGGSLPNVNQIGSSSVDLAFQTPFQSSGLDTSRTTRHHGLVDRVYRERGRLGSPHRRPLSVDKHGRQADSCPYGTVYLSPPADTSWRRTNSDSALHQSTMTPSQAESFTGGSQDAHQKRVLLLTVPGMEDTGAETDKTLSKQSWDSKKAGSRPKSCEVPGINIFPSADQENTTALIPATHNTGGSLPDLTNIHFPSPLPTPLDPEEPPFPALTSSSSTGSLAHLGVGGAGQGMNTPSSSPQHRPAVVSPLSLSTEARRQQAQQVSPTLSPLSPITQAVAMDALSLEQQLPYAFFTQTGSQQPPPQPQPPPPPPPVSQQQPPPPQVSVGLPQGGPLLPSASLTRGPQLPPLSVTVPSTLPQSPTENPGQSPMGIDATSAPALQYRTSAGSPATQSPTSPVSNQGFSPGSSPQHTSTLGSVFGDAYYEQQMTARQANALSRQLEQFNMMENAISSSSLYNPGSTLNYSQAAMMGLSGSHGGLQDPQQLGYTGHGGIPNIILTVTGESPPSLSKELSSTLAGVSDVSFDSDHQFPLDELKIDPLTLDGLHMLNDPDMVLADPATEDTFRMDRL
uniprot
proteins
function
FUNCTION: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites (PubMed:29211348). Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated (PubMed:29211348). Acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells (By similarity). In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons. In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. {ECO:0000250|UniProtKB:Q157S1, ECO:0000250|UniProtKB:Q6UUV9, ECO:0000269|PubMed:17360587, ECO:0000269|PubMed:23699513, ECO:0000269|PubMed:23993098, ECO:0000269|PubMed:29211348}.
uniprot
proteins
mass_dalton
66945
uniprot
proteins
mutagenesis
MUTAGEN 64; /note="S->A: Up-regulates CREB transcription factor activity."; /evidence="ECO:0000269|PubMed:28235073"; MUTAGEN 151; /note="S->A: Up-regulates CREB transcription factor activity. Reduces interaction with 14-3-3 proteins."; /evidence="ECO:0000269|PubMed:28235073"; MUTAGEN 245; /note="S->A: No effect on interaction with 14-3-3 proteins."; /evidence="ECO:0000269|PubMed:28235073
uniprot
proteins
post_translational_modification
PTM: Phosphorylation/dephosphorylation states of Ser-151 are required for regulating transduction of CREB activity. TORCs are inactive when phosphorylated, and active when dephosphorylated at this site. This primary site of phosphorylation is mediated by SIKs (SIK1 and SIK2), is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs by LKB1. {ECO:0000269|PubMed:23993098}.
uniprot
proteins
protein_family
TORC family
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17360587
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23699513
uniprot
proteins
pubmed
23993098
uniprot
proteins
pubmed
28235073
uniprot
proteins
pubmed
29211348
uniprot
proteins
pubmed
30611118
uniprot
proteins
sequence_length
630
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17360587, ECO:0000269|PubMed:23993098}. Nucleus {ECO:0000269|PubMed:17360587, ECO:0000269|PubMed:23699513, ECO:0000269|PubMed:23993098}. Note=Cytoplasmic when phosphorylated by SIK or AMPK and when sequestered by 14-3-3 proteins (By similarity). Translocated to the nucleus on Ser-151 dephosphorylation, instigated by a number of factors including calcium ion and cAMP levels (By similarity). Light stimulation triggers a nuclear accumulation in the suprachiasmatic nucleus (SCN) of the brain (PubMed:23699513). {ECO:0000250|UniProtKB:Q6UUV9, ECO:0000269|PubMed:23699513}.
uniprot
proteins