PKN3
entrez
29941
canonical
uniprot
Q6P5Z2
canonical
ensembl
ENSG00000160447
resolver
ensp
ENSP00000291906
resolver
ensp
ENSP00000788910
resolver
enst
ENST00000291906
resolver
genesymbol
PKN3
resolver
genesymbol_syn
PKNBETA
resolver
hgnc
HGNC:17999
resolver
uniprot
Q9UM03
resolver
uniprot_entry
PKN3_HUMAN
resolver
uniprot_sec
Q9UM03
resolver
activity_regulation
ACTIVITY REGULATION: Two specific sites, Thr-718 (activation loop of the kinase domain) and Thr-860 (turn motif), need to be phosphorylated for its full activation. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MEEGAPRQPGPSQWPPEDEKEVIRRAIQKELKIKEGVENLRRVATDRRHLGHVQQLLRSSNRRLEQLHGELRELHARILLPGPGPGPAEPVASGPRPWAEQLRARHLEALRRQLHVELKVKQGAENMTHTCASGTPKERKLLAAAQQMLRDSQLKVALLRMKISSLEASGSPEPGPELLAEELQHRLHVEAAVAEGAKNVVKLLSSRRTQDRKALAEAQAQLQESSQKLDLLRLALEQLLEQLPPAHPLRSRVTRELRAAVPGYPQPSGTPVKPTALTGTLQVRLLGCEQLLTAVPGRSPAAALASSPSEGWLRTKAKHQRGRGELASEVLAVLKVDNRVVGQTGWGQVAEQSWDQTFVIPLERARELEIGVHWRDWRQLCGVAFLRLEDFLDNACHQLSLSLVPQGLLFAQVTFCDPVIERRPRLQRQERIFSKRRGQDFLRASQMNLGMAAWGRLVMNLLPPCSSPSTISPPKGCPRTPTTLREASDPATPSNFLPKKTPLGEEMTPPPKPPRLYLPQEPTSEETPRTKRPHMEPRTRRGPSPPASPTRKPPRLQDFRCLAVLGRGHFGKVLLVQFKGTGKYYAIKALKKQEVLSRDEIESLYCEKRILEAVGCTGHPFLLSLLACFQTSSHACFVTEFVPGGDLMMQIHEDVFPEPQARFYVACVVLGLQFLHEKKIIYRDLKLDNLLLDAQGFLKIADFGLCKEGIGFGDRTSTFCGTPEFLAPEVLTQEAYTRAVDWWGLGVLLYEMLVGECPFPGDTEEEVFDCIVNMDAPYPGFLSVQGLEFIQKLLQKCPEKRLGAGEQDAEEIKVQPFFRTTNWQALLARTIQPPFVPTLCGPADLRYFEGEFTGLPPALTPPAPHSLLTARQQAAFRDFDFVSERFLEP
uniprot
proteins
ec_number
2.7.11.13
uniprot
proteins
function
FUNCTION: Contributes to invasiveness in malignant prostate cancer. {ECO:0000269|PubMed:15282551}.
uniprot
proteins
mass_dalton
99421
uniprot
proteins
mutagenesis
MUTAGEN 588; /note="K->E: Abolishes autophosphorylation and catalytic activity."; /evidence="ECO:0000269|PubMed:10441506, ECO:0000269|PubMed:15282551"; MUTAGEN 588; /note="K->R: Abolishes catalytic activity."; /evidence="ECO:0000269|PubMed:10441506, ECO:0000269|PubMed:15282551"; MUTAGEN 718; /note="T->A: Abolishes phosphorylation."; /evidence="ECO:0000269|PubMed:15282551
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. {ECO:0000269|PubMed:15282551}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
PKC subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10441506
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15282551
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
889
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10441506}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10441506}. Note=Nuclear and perinuclear Golgi region.
uniprot
proteins