Lrrc25
entrez
211228
canonical
uniprot
Q8K1T1
canonical
ensembl
ENSMUSG00000049988
resolver
ensp
ENSMUSP00000049686
resolver
enst
ENSMUST00000052437
resolver
genesymbol
Lrrc25
resolver
genesymbol_syn
Mapa
resolver
uniprot
B9EHD0
resolver
uniprot
Q3TAD5
resolver
uniprot_entry
B9EHD0_MOUSE
resolver
uniprot_entry
LRC25_MOUSE
resolver
uniprot_sec
Q3TAD5
resolver
amino_acid_sequence
MGSIRTRLLWLCLLMLLALLHKSGSQDLTCMVHPSRVDWTQTFNGTCLNFSGLGLSLPRSPLQASHAQVLDLSKNGLQVLPGAFFDKLEKLQTLIVTHNQLDSVDRSLALRCDLELKADCSCGLASWYALRQNCSGQQQLLCLHPATEAPRNLSTFLQVSCPPSWGPGTIGALVAGTISLAVAVSGSVLAWRLLRRRRRASEHSLSKAQMSPHDIPKPVTDFLPRYSSRRPGPKAPDSPPSRFTMDYENVFIGQPAEDCSWSAARNSPSGDSDCYMNYRSVDQDSQPVYCNLESLGR
uniprot
proteins
function
FUNCTION: Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting RIGI for autophagic degradation. Interacts specifically with ISG15-associated RIGI to promote interaction between RIGI and the autophagic cargo receptor p62/SQSTM1 to mediate RIGI degradation via selective autophagy. Plays also a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA. {ECO:0000250|UniProtKB:Q8N386}.
uniprot
proteins
mass_dalton
32673
uniprot
proteins
pubmed
12384430
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
297
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q8N386}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q8N386}. Cytoplasm {ECO:0000250|UniProtKB:Q8N386}.
uniprot
proteins
transmembrane_region
TRANSMEM 170..190; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins