CAND1
entrez
55832
canonical
uniprot
Q86VP6
canonical
ensembl
ENSG00000111530
resolver
ensp
ENSP00000442318
resolver
genesymbol
CAND1
resolver
genesymbol_syn
KIAA0829
resolver
genesymbol_syn
TIP120
resolver
genesymbol_syn
TIP120A
resolver
hgnc
HGNC:30688
resolver
uniprot
B2RAU3
resolver
uniprot
O94918
resolver
uniprot
Q6PIY4
resolver
uniprot
Q8NDJ4
resolver
uniprot
Q96JZ9
resolver
uniprot
Q96T19
resolver
uniprot
Q9BTC4
resolver
uniprot
Q9H0G2
resolver
uniprot
Q9P0H7
resolver
uniprot
Q9UF85
resolver
uniprot_entry
CAND1_HUMAN
resolver
uniprot_sec
B2RAU3
resolver
uniprot_sec
O94918
resolver
uniprot_sec
Q6PIY4
resolver
uniprot_sec
Q8NDJ4
resolver
uniprot_sec
Q96JZ9
resolver
uniprot_sec
Q96T19
resolver
uniprot_sec
Q9BTC4
resolver
uniprot_sec
Q9H0G2
resolver
uniprot_sec
Q9P0H7
resolver
uniprot_sec
Q9UF85
resolver
amino_acid_sequence
MASASYHISNLLEKMTSSDKDFRFMATNDLMTELQKDSIKLDDDSERKVVKMILKLLEDKNGEVQNLAVKCLGPLVSKVKEYQVETIVDTLCTNMLSDKEQLRDISSIGLKTVIGELPPASSGSALAANVCKKITGRLTSAIAKQEDVSVQLEALDIMADMLSRQGGLLVNFHPSILTCLLPQLTSPRLAVRKRTIIALGHLVMSCGNIVFVDLIEHLLSELSKNDSMSTTRTYIQCIAAISRQAGHRIGEYLEKIIPLVVKFCNVDDDELREYCIQAFESFVRRCPKEVYPHVSTIINICLKYLTYDPNYNYDDEDEDENAMDADGGDDDDQGSDDEYSDDDDMSWKVRRAAAKCLDAVVSTRHEMLPEFYKTVSPALISRFKEREENVKADVFHAYLSLLKQTRPVQSWLCDPDAMEQGETPLTMLQSQVPNIVKALHKQMKEKSVKTRQCCFNMLTELVNVLPGALTQHIPVLVPGIIFSLNDKSSSSNLKIDALSCLYVILCNHSPQVFHPHVQALVPPVVACVGDPFYKITSEALLVTQQLVKVIRPLDQPSSFDATPYIKDLFTCTIKRLKAADIDQEVKERAISCMGQIICNLGDNLGSDLPNTLQIFLERLKNEITRLTTVKALTLIAGSPLKIDLRPVLGEGVPILASFLRKNQRALKLGTLSALDILIKNYSDSLTAAMIDAVLDELPPLISESDMHVSQMAISFLTTLAKVYPSSLSKISGSILNELIGLVRSPLLQGGALSAMLDFFQALVVTGTNNLGYMDLLRMLTGPVYSQSTALTHKQSYYSIAKCVAALTRACPKEGPAVVGQFIQDVKNSRSTDSIRLLALLSLGEVGHHIDLSGQLELKSVILEAFSSPSEEVKSAASYALGSISVGNLPEYLPFVLQEITSQPKRQYLLLHSLKEIISSASVVGLKPYVENIWALLLKHCECAEEGTRNVVAECLGKLTLIDPETLLPRLKGYLISGSSYARSSVVTAVKFTISDHPQPIDPLLKNCIGDFLKTLEDPDLNVRRVALVTFNSAAHNKPSLIRDLLDTVLPHLYNETKVRKELIREVEMGPFKHTVDDGLDIRKAAFECMYTLLDSCLDRLDIFEFLNHVEDGLKDHYDIKMLTFLMLVRLSTLCPSAVLQRLDRLVEPLRATCTTKVKANSVKQEFEKQDELKRSAMRAVAALLTIPEAEKSPLMSEFQSQISSNPELAAIFESIQKDSSSTNLESMDTS
uniprot
proteins
function
FUNCTION: Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. {ECO:0000269|PubMed:12504025, ECO:0000269|PubMed:12504026, ECO:0000269|PubMed:12609982, ECO:0000269|PubMed:16449638, ECO:0000269|PubMed:21249194, ECO:0000269|PubMed:23453757}.
uniprot
proteins
mass_dalton
136376
uniprot
proteins
protein_family
CAND family
uniprot
proteins
pubmed
10048485
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12504025
uniprot
proteins
pubmed
12504026
uniprot
proteins
pubmed
12609982
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15537541
uniprot
proteins
pubmed
16449638
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20820187
uniprot
proteins
pubmed
21249194
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21778237
uniprot
proteins
pubmed
22118460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23453757
uniprot
proteins
pubmed
24192928
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25349211
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26030138
uniprot
proteins
pubmed
26906416
uniprot
proteins
sequence_length
1230
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21249194}. Nucleus {ECO:0000269|PubMed:21249194}. Note=Predominantly cytoplasmic.
uniprot
proteins