Pagr1a
entrez
67278
canonical
uniprot
Q99L02
canonical
ensembl
ENSMUSG00000030680
resolver
ensembl
ENSMUSG00000107068
resolver
ensp
ENSMUSP00000144243
resolver
ensp
ENSMUSP00000144469
resolver
enst
ENSMUST00000200948
resolver
enst
ENSMUST00000202798
resolver
genesymbol
Pagr1a
resolver
genesymbol_syn
Pa1
resolver
genesymbol_syn
Pagr
resolver
uniprot_entry
PGR1A_MOUSE
resolver
amino_acid_sequence
MSLALGHGTIAGSTAAPLSEEGEVTSGLQALAVEDTGGPSVSASKAEEEGKGSQEEAGREGSRPEEALEAPSAASDERAEGEAEDWCVPCSDEEVELPANGQSWMPPPSEIQRLYELLATQGTLELQAEILPRRPPTPEAQSEEERSDEEPEAKEEEEEKPHMPTEFDFDDEPMTPKDSLIDRRRTPGSSARSQKREARLDKVLSDMKRHKKLEEQILRTGRDLFSLDSEGPSPTSPPLRSSGNSLFPRQRKY
uniprot
proteins
function
FUNCTION: Its association with the histone methyltransferase MLL2/MLL3 complex is suggesting a role in epigenetic transcriptional activation. However, in association with PAXIP1/PTIP is proposed to function at least in part independently of the MLL2/MLL3 complex. Proposed to be recruited by PAXIP1 to sites of DNA damage where the PAGR1:PAXIP1 complex is required for cell survival in response to DNA damage independently of the MLL2/MLL3 complex (PubMed:19124460). However, its function in DNA damage has been questioned (PubMed:26744420). During immunoglobulin class switching in activated B-cells is involved in transcription regulation of downstream switch regions at the immunoglobulin heavy-chain (Igh) locus independently of the MLL2/MLL3 complex (PubMed:26744420). Involved in both estrogen receptor-regulated gene transcription and estrogen-stimulated G1/S cell-cycle transition (By similarity). Acts as a transcriptional cofactor for nuclear hormone receptors. Inhibits the induction properties of several steroid receptors such as NR3C1, AR and PPARG; the mechanism of inhibition appears to be gene-dependent (By similarity). May be involved in the regulation of the BMP pathway in extraembryonic development (PubMed:24633704). {ECO:0000250|UniProtKB:Q9BTK6, ECO:0000269|PubMed:19124460, ECO:0000269|PubMed:26744420, ECO:0000305, ECO:0000305|PubMed:24633704}.
uniprot
proteins
mass_dalton
27723
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19124460
uniprot
proteins
pubmed
24633704
uniprot
proteins
pubmed
26744420
uniprot
proteins
sequence_length
253
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26744420}.
uniprot
proteins