Arl13b
entrez
68146
canonical
uniprot
Q640N2
canonical
ensembl
ENSMUSG00000022911
resolver
ensp
ENSMUSP00000086703
resolver
ensp
ENSMUSP00000264709
resolver
enst
ENSMUST00000089289
resolver
genesymbol
Arl13b
resolver
genesymbol_syn
Arl2l1
resolver
uniprot
G3X9K5
resolver
uniprot
Q9CUD0
resolver
uniprot_entry
AR13B_MOUSE
resolver
uniprot_entry
Q9CUD0_MOUSE
resolver
uniprot_sec
G3X9K5
resolver
amino_acid_sequence
MFSLMANCCNLFKRWREPVRKVTLVMVGLDNAGKTATAKGIQGEHPEDVAPTVGFSKIDLRQGKFQVTIFDLGGGKRIRGIWKNYYAESYGVIFVVDSSDEERMEETKETMSEVLRHPRISGKPILVLANKQDKEGALGEADVIECLSLEKLVNEHKCLCQIEPCSAVLGYGKKIDKSIKKGLYWLLHIIAKDFDALSERIQKDTTEQRALEEQEKRERAERVRKLREEREREQTELDGTSGLAEIDSGPVLANPFQPIAAVIIENEKKQEKEKKKQTVEKDSDVGLLEHKVEPEQAAPQSEADCCLQNPDERVVDSYREALSQQLDSEDEQDQRGSESGENSKKKTKKLRMKRSHRVEPVNTDESTPKSPTPPQPPPPVGWGTPKVTRLPKLEPLGETRHNDFYGKPLPPLAVRQRPNGDAQDTIS
uniprot
proteins
function
FUNCTION: Cilium-specific protein required to control the microtubule-based, ciliary axoneme structure. May act by maintaining the association between IFT subcomplexes A and B. Binds GTP but is not able to hydrolyze it; the GTPase activity remains unclear. Required to pattern the neural tube. Involved in cerebral cortex development: required for the initial formation of a polarized radial glial scaffold, the first step in the construction of the cerebral cortex, by regulating ciliary signaling (PubMed:23817546). Regulates the migration and placement of postmitotic interneurons in the developing cerebral cortex (PubMed:23153492). Plays a role in ciliar trafficking of phosphatidylinositol phosphatase INPP5E in ciliogenesis (By similarity). May regulate ARF6- and RAB22A-dependent endocytic recycling traffic (By similarity). {ECO:0000250|UniProtKB:Q3SXY8, ECO:0000269|PubMed:17488627, ECO:0000269|PubMed:21539826, ECO:0000269|PubMed:21976698, ECO:0000269|PubMed:22554696, ECO:0000269|PubMed:23014696, ECO:0000269|PubMed:23153492, ECO:0000269|PubMed:23817546}.
uniprot
proteins
mass_dalton
48144
uniprot
proteins
mutagenesis
MUTAGEN 8..9; /note="CC->SS: Abolishes palmitoylation and localization to the cilium membrane."; /evidence="ECO:0000269|PubMed:20231383"; MUTAGEN 358; /note="V->A: Abolishes localization to cilium."; /evidence="ECO:0000269|PubMed:23153492
uniprot
proteins
post_translational_modification
PTM: Sumoylation is required for PKD2 entry into cilium. {ECO:0000250}.
uniprot
proteins
protein_family
Arf family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17488627
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20231383
uniprot
proteins
pubmed
20643351
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21539826
uniprot
proteins
pubmed
21976698
uniprot
proteins
pubmed
22554696
uniprot
proteins
pubmed
23014696
uniprot
proteins
pubmed
23153492
uniprot
proteins
pubmed
23817546
uniprot
proteins
pubmed
24120134
uniprot
proteins
pubmed
24339792
uniprot
proteins
pubmed
25138100
uniprot
proteins
pubmed
26582389
uniprot
proteins
sequence_length
427
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000269|PubMed:17488627, ECO:0000269|PubMed:20231383, ECO:0000269|PubMed:21976698, ECO:0000269|PubMed:23153492, ECO:0000269|PubMed:23817546, ECO:0000269|PubMed:24120134, ECO:0000269|PubMed:24339792, ECO:0000269|PubMed:26582389}; Lipid-anchor {ECO:0000269|PubMed:17488627, ECO:0000269|PubMed:20231383, ECO:0000269|PubMed:21976698, ECO:0000269|PubMed:23153492, ECO:0000269|PubMed:23817546, ECO:0000269|PubMed:24120134, ECO:0000269|PubMed:24339792}. Cell projection, cilium {ECO:0000269|PubMed:25138100}. Note=Associates with the cilium membrane via palmitoylation. Localizes to proximal ciliary membranes, to an inversin-like subciliary membrane compartment, excluding the transition zone.
uniprot
proteins