Mef2d
entrez
81518
canonical
uniprot
O89038
canonical
ensembl
ENSRNOG00000031778
resolver
ensp
ENSRNOP00000041061
resolver
enst
ENSRNOT00000051394
resolver
genesymbol
Mef2d
resolver
uniprot
A0A0G2JSU7
resolver
uniprot
Q66HL8
resolver
uniprot_entry
A0A0G2JSU7_RAT
resolver
uniprot_entry
MEF2D_RAT
resolver
uniprot_sec
Q66HL8
resolver
amino_acid_sequence
MGRKKIQIQRITDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNHSNKLFQYASTDMDKVLLKYTEYNEPHESRTNADIIETLRKKGFNGCDSPEPDGEDSLEQSPLLEDKYRRASEELDGLFRRYGSSVPAPNFAMPVTVPVSNQSSMQFSNPSSSLVTPSLVTSSLTDPRLLSPQQPALQRNSVSPGLPQRPASAGAMLGRDLNSANGACPNPVGNGYVSARASPGLLPVANGNGLNKVIPAKSPPPPTHNTQLGAPSRKPDLRVITSQGGKGLMHHLNNAQRLGVSQSTHSLTTPVVSVATPSLLSQGLPFSSMPTAYNTDYQLPSAELSSLPAFSSPAGLALGNVTAWQQPQQPQQPQPPQPPQSQPQPPQPQPQQPPQQQPHLVPVSLSNLIPGSPLPHVGAALTVTTHPHISIKSEPVSPSRERSPAPPPPAVFPAARPEPGEGLSSPAGGSYETGDRDDGRGDFGPTLGLLRPAPEPEAEGSAVKRMRLDTWTLK
uniprot
proteins
function
FUNCTION: Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
54368
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser-430 by CDK5 is required for Lys-425 sumoylation and inhibits transcriptional activity. In neurons, enhanced CDK5 activity induced by neurotoxins promotes caspase 3-mediated cleavage leading to neuron apoptosis. Phosphorylation on Ser-180 can be enhanced by EGF. Phosphorylated and activated by CaMK4 (By similarity). {ECO:0000250}.; PTM: Acetylated on Lys-425 by CREBBP. Acetylated by EP300. Deacetylated by SIRT1 and HDAC3 (By similarity). {ECO:0000250|UniProtKB:Q14814}.; PTM: Sumoylated on Lys-425 with SUMO2 but not SUMO1; which inhibits transcriptional activity and myogenic activity. Desumoylated by SENP3 (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9753748
uniprot
proteins
sequence_length
507
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Note=Translocated by HDAC4 to nuclear dots. {ECO:0000250}.
uniprot
proteins