TYMP
entrez
1890
canonical
uniprot
P19971
canonical
ensembl
ENSG00000025708
resolver
ensp
ENSP00000252029
resolver
ensp
ENSP00000379036
resolver
ensp
ENSP00000379037
resolver
ensp
ENSP00000379038
resolver
ensp
ENSP00000498844
resolver
genesymbol
TYMP
resolver
genesymbol_syn
ECGF1
resolver
hgnc
HGNC:3148
resolver
uniprot
A8MW15
resolver
uniprot
B2RBL3
resolver
uniprot
E5KRG5
resolver
uniprot
H9KVA0
resolver
uniprot
Q13390
resolver
uniprot
Q8WVB7
resolver
uniprot_entry
B2RBL3_HUMAN
resolver
uniprot_entry
E5KRG5_HUMAN
resolver
uniprot_entry
TYPH_HUMAN
resolver
uniprot_sec
A8MW15
resolver
uniprot_sec
H9KVA0
resolver
uniprot_sec
Q13390
resolver
uniprot_sec
Q8WVB7
resolver
amino_acid_sequence
MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAAVVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGGVGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQAGCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAAVFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPPDLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARALCSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVGAELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPPQQ
uniprot
proteins
disease_involvement
DISEASE: Mitochondrial DNA depletion syndrome 1, MNGIE type (MTDPS1) [MIM:603041]: A multisystem disease associated with mitochondrial dysfunction. It is clinically characterized by onset between the second and fifth decades of life, ptosis, progressive external ophthalmoplegia, gastrointestinal dysmotility (often pseudoobstruction), diffuse leukoencephalopathy, cachexia, peripheral neuropathy, and myopathy. {ECO:0000269|PubMed:12177387, ECO:0000269|PubMed:9924029}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.4.2.4
uniprot
proteins
function
FUNCTION: May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. {ECO:0000269|PubMed:1590793}.; FUNCTION: Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. {ECO:0000269|PubMed:1590793}.
uniprot
proteins
mass_dalton
49955
uniprot
proteins
mutagenesis
MUTAGEN 199; /note="Y->A: Abolishes catalytic activity."; /evidence="ECO:0000269|PubMed:19555658"; MUTAGEN 199; /note="Y->F: Reduced catalytic activity."; /evidence="ECO:0000269|PubMed:19555658"; MUTAGEN 199; /note="Y->L: Reduced catalytic activity."; /evidence="ECO:0000269|PubMed:19555658
uniprot
proteins
pathway_participation
PATHWAY: Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2. {ECO:0000269|PubMed:1590793}.
uniprot
proteins
protein_family
Thymidine/pyrimidine-nucleoside phosphorylase family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
12177387
uniprot
proteins
pubmed
1400349
uniprot
proteins
pubmed
14725767
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1570012
uniprot
proteins
pubmed
1580101
uniprot
proteins
pubmed
1590793
uniprot
proteins
pubmed
16803458
uniprot
proteins
pubmed
19555658
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2467210
uniprot
proteins
pubmed
9924029
uniprot
proteins
sequence_length
482
uniprot
proteins