Dynll1
entrez
58945
canonical
uniprot
P63170
canonical
ensembl
ENSRNOG00000083010
resolver
ensembl
ENSRNOG00055001858
resolver
ensembl
ENSRNOG00060006482
resolver
ensembl
ENSRNOG00065006260
resolver
ensp
ENSRNOP00000106438
resolver
ensp
ENSRNOP00055002266
resolver
ensp
ENSRNOP00060007875
resolver
ensp
ENSRNOP00065006882
resolver
enst
ENSRNOT00000165275
resolver
enst
ENSRNOT00055003006
resolver
enst
ENSRNOT00060010625
resolver
enst
ENSRNOT00065009572
resolver
genesymbol
Dynll1
resolver
genesymbol_syn
Dncl1
resolver
genesymbol_syn
Dnclc1
resolver
genesymbol_syn
Pin
resolver
uniprot
Q15701
resolver
uniprot_entry
DYL1_RAT
resolver
uniprot_sec
Q15701
resolver
amino_acid_sequence
MCDRKAVIKNADMSEEMQQDSVECATQALEKYNIEKDIAAHIKKEFDKKYNPTWHCIVGRNFGSYVTHETKHFIYFYLGQVAILLFKSG
uniprot
proteins
function
FUNCTION: Component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Required for structural and functional integrity of cilia (By similarity). Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (PubMed:11746667, PubMed:8702622). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (PubMed:11746667, PubMed:8702622). May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (PubMed:11746667, PubMed:8702622). In addition to its role in cytoskeleton and transport, acts as a protein-protein adapter, which inhibits and/or sequesters target proteins (By similarity). Involved in the response to DNA damage by acting as a key regulator of DNA end resection: when phosphorylated at Ser-88, recruited to DNA double-strand breaks (DSBs) by TP53BP1 and acts by disrupting MRE11 dimerization, thereby inhibiting DNA end resection (By similarity). In a subset of DSBs, DYNLL1 remains unphosphorylated and promotes the recruitment of the Shieldin complex (By similarity). Binds and inhibits the catalytic activity of neuronal nitric oxide synthase/NOS1 (PubMed:8864115). Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1 (By similarity). Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules (By similarity). Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity (By similarity). {ECO:0000250|UniProtKB:P63167, ECO:0000250|UniProtKB:W7XJB1, ECO:0000269|PubMed:11746667, ECO:0000269|PubMed:8702622, ECO:0000269|PubMed:8864115}.
uniprot
proteins
mass_dalton
10366
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-88 promotes recruitment to DNA double-strand breaks (DSBs) by TP53BP1 and ability to inhibit MRE11. {ECO:0000250|UniProtKB:P63167}.
uniprot
proteins
protein_family
Dynein light chain family
uniprot
proteins
pubmed
11178896
uniprot
proteins
pubmed
11602781
uniprot
proteins
pubmed
11746667
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16133941
uniprot
proteins
pubmed
21478148
uniprot
proteins
pubmed
8702622
uniprot
proteins
pubmed
8864115
uniprot
proteins
pubmed
9299562
uniprot
proteins
sequence_length
89
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P63167}. Chromosome {ECO:0000250|UniProtKB:P63167}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:8702622}. Nucleus {ECO:0000250|UniProtKB:P63167}. Mitochondrion {ECO:0000250|UniProtKB:P63167}. Note=Upon induction of apoptosis translocates together with BCL2L11 to mitochondria. Recruited to DNA double-strand breaks (DSBs) by TP53BP1 when phosphorylated at Ser-88. {ECO:0000250|UniProtKB:P63167}.
uniprot
proteins