Atp5mc1
entrez
11951
canonical
uniprot
Q9CR84
canonical
ensembl
ENSMUSG00000006057
resolver
ensp
ENSMUSP00000088029
resolver
ensp
ENSMUSP00000103312
resolver
ensp
ENSMUSP00000103314
resolver
enst
ENSMUST00000090541
resolver
enst
ENSMUST00000107684
resolver
enst
ENSMUST00000107686
resolver
genesymbol
Atp5mc1
resolver
genesymbol_syn
Atp5g1
resolver
uniprot
Q3TIE9
resolver
uniprot_entry
AT5G1_MOUSE
resolver
uniprot_sec
Q3TIE9
resolver
amino_acid_sequence
MQTTKALLISPALIRSCTRGLIRPVSASLLSRPEAPSKQPSCSSSPLQVARREFQTSVISRDIDTAAKFIGAGAATVGVAGSGAGIGTVFGSLIIGYARNPSLKQQLFSYAILGFALSEAMGLFCLMVAFLILFAM
uniprot
proteins
disease_involvement
DISEASE: Note=This protein is the major protein stored in the storage bodies of animals or humans affected with ceroid lipofuscinosis (Batten disease).
uniprot
proteins
function
FUNCTION: Subunit c, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. With the subunit a (MT-ATP6), forms the proton-conducting channel in the F(0) domain, that contains two crucial half-channels (inlet and outlet) that facilitate proton movement from the mitochondrial intermembrane space (IMS) into the matrix. Protons are taken up via the inlet half-channel and released through the outlet half-channel, following a Grotthuss mechanism. {ECO:0000250|UniProtKB:P05496}.
uniprot
proteins
mass_dalton
14200
uniprot
proteins
post_translational_modification
PTM: Trimethylated by ATPSCKMT at Lys-104. Methylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration. {ECO:0000269|PubMed:30530489}.
uniprot
proteins
protein_family
ATPase C chain family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
30530489
uniprot
proteins
sequence_length
136
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 77..97; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 112..132; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins