Thrap3
entrez
313591
canonical
uniprot
Q5M7V8
canonical
ensembl
ENSRNOG00000009977
resolver
ensembl
ENSRNOG00055012812
resolver
ensembl
ENSRNOG00060014217
resolver
ensembl
ENSRNOG00065029486
resolver
ensp
ENSRNOP00000085793
resolver
ensp
ENSRNOP00055017746
resolver
ensp
ENSRNOP00060019433
resolver
ensp
ENSRNOP00065041891
resolver
enst
ENSRNOT00000106551
resolver
enst
ENSRNOT00055021904
resolver
enst
ENSRNOT00060024350
resolver
enst
ENSRNOT00065050942
resolver
genesymbol
Thrap3
resolver
genesymbol_syn
Trap150
resolver
uniprot
A0A8I6A105
resolver
uniprot_entry
A0A8I6A105_RAT
resolver
uniprot_entry
TR150_RAT
resolver
amino_acid_sequence
MSKTNKSKSGSRSSRSRSASRSRSRSFSKSRSRSRSVSRSRKRRLSSRSRSRSYSPAHNRERNHPRVYQNRDFRGHNRGYRRPYYFRGRNRGFYPWGQYNRGGYGNYRSNWQNYRQAYSPRRGRSRSRSPKRRSPSPRSRSHSRNSDKSSSDRSRRSSSSRSSSNHSRVESSKRKSTKEKKSSSKDSRPSQAAGDNQGDEAKEQTFSGGTSQDIKGSESSKPWPDATTYGTGSASRASVSDLSPRERSPALKSPLQSVVVRRRSPRPSPVPKPSPPLSNASQMGSSMSGGAGYQSGAHQGPFDHGSGSLSPSKKSPVGKSPPATGSAYGSSQKEESAASGGAAYTKRYLEEQKTENGKDKEQKQTNTDKEKLKEKGGFSDADVKMKSDPFAPKTDTEKPFRGSQSPKRYKLRDDFEKKMADFHKEEMDEQDKDKCKGRKEPEFDDEPKFISKVIAGASKNQEEEKSGKWESLHAGKEKQRKAEELEEEPFTERSRKEERGGSKRSESGHRGFVPEKNFRVTAYKAVQEKSSSPPPRKTSESRDKLGNKGDFSSGKSSFSITREAQVNVRMDSFDEDLARPSGLLAQERKLCRDLVHSNKKEQEFRSIFQHIQSAQSQRSPSELFAQHIVTIVHHVKEHHFGSSGMTLHERFTKYLKRGNEQEAAKTKKSPEIHRRIDISPSTFRKHGLTHEELKSPREPGYKAEGKYKDDPVDLRLDIERRKKHKERDLKRGKSRESVDSRDSSHSRERSTEKTEKTHKGSKKQKKHRRARDRSRSSSSSSQSSHSYKAEEYPEEAEDREESTTGFDKSRLGTKDFVGPNERGGRARGTFQFRARGRGWGRGNYSGNNNNNSNNDFQKRSREEEWDPEYTPKSKKYYLHDDREGEGSDKWMSRGRGRGAFPRGRGRFMFRKSSTSPKWAHDKFSGEEGEIEDDESGTENREEKDSLQPSAE
uniprot
proteins
function
FUNCTION: Involved in pre-mRNA splicing. Remains associated with spliced mRNA after splicing which probably involves interactions with the exon junction complex (EJC). Can trigger mRNA decay which seems to be independent of nonsense-mediated decay involving premature stop codons (PTC) recognition. May be involved in nuclear mRNA decay. Involved in regulation of signal-induced alternative splicing. During splicing of PTPRC/CD45 is proposed to sequester phosphorylated SFPQ from PTPRC/CD45 pre-mRNA in resting T-cells. Involved in cyclin-D1/CCND1 mRNA stability probably by acting as component of the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in response to DNA damage. Is excluced from DNA damage sites in a manner that parallels transcription inhibition; the function may involve the SNARP complex. Initially thought to play a role in transcriptional coactivation through its association with the TRAP complex; however, it is not regarded as a stable Mediator complex subunit. Cooperatively with HELZ2, enhances the transcriptional activation mediated by PPARG, maybe through the stabilization of the PPARG binding to DNA in presence of ligand. May play a role in the terminal stage of adipocyte differentiation. Plays a role in the positive regulation of the circadian clock. Acts as a coactivator of the CLOCK-BMAL1 heterodimer and promotes its transcriptional activator activity and binding to circadian target genes. {ECO:0000250|UniProtKB:Q569Z6, ECO:0000250|UniProtKB:Q9Y2W1}.
uniprot
proteins
mass_dalton
108252
uniprot
proteins
protein_family
BCLAF1/THRAP3 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
951
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q569Z6}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9Y2W1}. Nucleus speckle {ECO:0000250|UniProtKB:Q9Y2W1}.
uniprot
proteins