Grk5
entrez
59075
canonical
uniprot
Q62833
canonical
ensembl
ENSRNOG00000011439
resolver
ensp
ENSRNOP00000015687
resolver
ensp
ENSRNOP00000104808
resolver
enst
ENSRNOT00000015687
resolver
enst
ENSRNOT00000139040
resolver
genesymbol
Grk5
resolver
genesymbol_syn
Gprk5
resolver
uniprot
A0ABK0LSM1
resolver
uniprot
A0ACM8Q5K7
resolver
uniprot
A6JIB2
resolver
uniprot
Q66HL7
resolver
uniprot_entry
A0ABK0LSM1_RAT
resolver
uniprot_entry
A0ACM8Q5K7_RAT
resolver
uniprot_entry
A6JIB2_RAT
resolver
uniprot_entry
GRK5_RAT
resolver
uniprot_sec
Q66HL7
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by calmodulin with an IC(50) of 50 nM. Calmodulin inhibits GRK5 association with receptor and phospholipid (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MELENIVANTVLLKAREGGGGKRKGKSKKWKEILKFPHINQCEDLRRTIDRDYYSLCDKQPIGRLLFRQFCETRPGLECYIQFLDLVAEYEITPDENLGAKGKEIMTKYLSPKSPVFIAQVGQDLVSQTEKKLLQSPCKELFSACAQSVHDYLKGDPFHEYLDSMYFDRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFHIYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGLSPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSPKFSEEAKSICNMLLTKDSKQRLGCQEEGAAEVKRHPFFRNMNFKRLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVPIPWQNEMIETECFKELNVFGPNGTLSPDLNRSQPPEPPKKGLFHRLFRRQHQNNSKSSPTPKTSCNHRINSNHINSNSTGSS
uniprot
proteins
ec_number
2.7.11.16
uniprot
proteins
function
FUNCTION: Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G protein-coupled receptor, LRP6 during Wnt signaling (in vitro) (By similarity). {ECO:0000250, ECO:0000269|PubMed:8631993}.
uniprot
proteins
mass_dalton
67783
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. Autophosphorylation may play a critical role in the regulation of GRK5 kinase activity. {ECO:0000250|UniProtKB:P34947}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
GPRK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11687284
uniprot
proteins
pubmed
11709416
uniprot
proteins
pubmed
12052842
uniprot
proteins
pubmed
8626574
uniprot
proteins
pubmed
8631993
uniprot
proteins
pubmed
9826657
uniprot
proteins
sequence_length
590
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12052842}. Nucleus {ECO:0000269|PubMed:12052842}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Predominantly localized at the plasma membrane, targeted to the cell surface through the interaction with phospholipids. Nucleus localization is regulated in a GPCR and Ca(2+)/calmodulin-dependent fashion (By similarity). {ECO:0000250}.
uniprot
proteins