PDGFC
entrez
56034
canonical
uniprot
Q9NRA1
canonical
ensembl
ENSG00000145431
resolver
ensp
ENSP00000422464
resolver
genesymbol
PDGFC
resolver
genesymbol_syn
SCDGF
resolver
hgnc
HGNC:8801
resolver
uniprot
B4DU34
resolver
uniprot
B9EGR8
resolver
uniprot
Q4W5M9
resolver
uniprot
Q9UL22
resolver
uniprot_entry
PDGFC_HUMAN
resolver
uniprot_sec
B4DU34
resolver
uniprot_sec
B9EGR8
resolver
uniprot_sec
Q4W5M9
resolver
uniprot_sec
Q9UL22
resolver
amino_acid_sequence
MSLFGLLLLTSALAGQRQGTQAESNLSSKFQFSSNKEQNGVQDPQHERIITVSTNGSIHSPRFPHTYPRNTVLVWRLVAVEENVWIQLTFDERFGLEDPEDDICKYDFVEVEEPSDGTILGRWCGSGTVPGKQISKGNQIRIRFVSDEYFPSEPGFCIHYNIVMPQFTEAVSPSVLPPSALPLDLLNNAITAFSTLEDLIRYLEPERWQLDLEDLYRPTWQLLGKAFVFGRKSRVVDLNLLTEEVRLYSCTPRNFSVSIREELKRTDTIFWPGCLLVKRCGGNCACCLHNCNECQCVPSKVTKKYHEVLQLRPKTGVRGLHKSLTDVALEHHEECDCVCRGSTGG
uniprot
proteins
function
FUNCTION: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function. {ECO:0000269|PubMed:10806482, ECO:0000269|PubMed:10858496, ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:11854040, ECO:0000269|PubMed:12032822, ECO:0000269|PubMed:15061151, ECO:0000269|PubMed:15372073, ECO:0000269|PubMed:15389578, ECO:0000269|PubMed:15728360, ECO:0000269|PubMed:15911618, ECO:0000269|PubMed:16439802, ECO:0000269|PubMed:18055825}.
uniprot
proteins
mass_dalton
39029
uniprot
proteins
mutagenesis
MUTAGEN 124; /note="C->S: Loss of mitogenic activity of CUB domain in coronary artery smooth muscle cells."; /evidence="ECO:0000269|PubMed:11854040"; MUTAGEN 231; /note="R->A: Essential for cleavage by PLAT."; /evidence="ECO:0000269|PubMed:15911618"; MUTAGEN 232; /note="K->A: Not essential for cleavage by PLAT."; /evidence="ECO:0000269|PubMed:15911618"; MUTAGEN 234; /note="R->A: Not essential for cleavage by PLAT."; /evidence="ECO:0000269|PubMed:15911618
uniprot
proteins
post_translational_modification
PTM: Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after basic residues in the hinge region (region connecting the CUB and growth factor domains) gives rise to the receptor-binding form. Cleaved by PLAT and PLG.; PTM: Sumoylated with SUMO1. {ECO:0000269|PubMed:16443219}.; PTM: N-glycosylated. {ECO:0000269|PubMed:11854040}.
uniprot
proteins
protein_family
PDGF/VEGF growth factor family
uniprot
proteins
pubmed
10806482
uniprot
proteins
pubmed
10858496
uniprot
proteins
pubmed
11004490
uniprot
proteins
pubmed
11297552
uniprot
proteins
pubmed
11313995
uniprot
proteins
pubmed
11342471
uniprot
proteins
pubmed
11854040
uniprot
proteins
pubmed
12032822
uniprot
proteins
pubmed
12176024
uniprot
proteins
pubmed
12598536
uniprot
proteins
pubmed
12707385
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15061151
uniprot
proteins
pubmed
15247255
uniprot
proteins
pubmed
15372073
uniprot
proteins
pubmed
15389578
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15728360
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
15911618
uniprot
proteins
pubmed
16279938
uniprot
proteins
pubmed
16439802
uniprot
proteins
pubmed
16443219
uniprot
proteins
pubmed
17482170
uniprot
proteins
pubmed
18055825
uniprot
proteins
pubmed
18172073
uniprot
proteins
sequence_length
345
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:16443219}. Secreted {ECO:0000269|PubMed:10806482, ECO:0000269|PubMed:10858496, ECO:0000269|PubMed:11297552, ECO:0000269|PubMed:15061151, ECO:0000269|PubMed:15372073, ECO:0000269|PubMed:15911618}. Nucleus {ECO:0000269|PubMed:16443219}. Cytoplasmic granule {ECO:0000269|PubMed:15061151}. Cell membrane {ECO:0000269|PubMed:16443219}. Note=Sumoylated form is predominant in the nucleus (PubMed:15247255). Stored in alpha granules in platelets (PubMed:15061151). {ECO:0000269|PubMed:16443219}.
uniprot
proteins