ERV3-1
entrez
2086
canonical
uniprot
Q14264
canonical
ensembl
ENSG00000213462
resolver
ensp
ENSP00000391594
resolver
enst
ENST00000394323
resolver
genesymbol
ERV3-1
resolver
genesymbol_syn
ERV3
resolver
hgnc
HGNC:3454
resolver
uniprot_entry
ENR1_HUMAN
resolver
amino_acid_sequence
MLGMNMLLITLFLLLPLSMLKGEPWEGCLHCTHTTWSGNIMTKTLLYHTYYECAGTCLGTCTHNQTTYSVCDPGRGQPYVCYDPKSSPGTWFEIHVGSKEGDLLNQTKVFPSGKDVVSLYFDVCQIVSMGSLFPVIFSSMEYYSSCHKNRYAHPACSTDSPVTTCWDCTTWSTNQQSLGPIMLTKIPLEPDCKTSTCNSVNLTILEPDQPIWTTGLKAPLGARVSGEEIGPGAYVYLYIIKKTRTRSTQQFRVFESFYEHVNQKLPEPPPLASNLFAQLAENIASSLHVASCYVCGGMNMGDQWPWEARELMPQDNFTLTASSLEPAPSSQSIWFLKTSIIGKFCIARWGKAFTDPVGELTCLGQQYYNETLGKTLWRGKSNNSESPHPSPFSRFPSLNHSWYQLEAPNTWQAPSGLYWICGPQAYRQLPAKWSGACVLGTIRPSFFLMPLKQGEALGYPIYDETKRKSKRGITIGDWKDNEWPPERIIQYYGPATWAEDGMWGYRTPVYMLNRIIRLQAVLEIITNETAGALNLLAQQATKMRNVIYQNRLALDYLLAQEEGVCGKFNLTNCCLELDDEGKVIKEITAKIQKLAHIPVQTWKG
uniprot
proteins
function
FUNCTION: Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its fusogenic properties. It can inhibit cell growth through decrease expression of cyclin B1 and increased expression of p21 in vitro. {ECO:0000269|PubMed:10692254, ECO:0000269|PubMed:14557543, ECO:0000269|PubMed:7645262}.; FUNCTION: SU mediates receptor recognition. {ECO:0000250}.; FUNCTION: TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
67942
uniprot
proteins
post_translational_modification
PTM: Specific enzymatic cleavages in vivo yield the mature SU and TM proteins (By similarity). Has been mainly detected in vivo as an 65 kDa unprocessed polyprotein precursor. {ECO:0000250}.; PTM: The CXXC motif is highly conserved across a broad range of retroviral envelope proteins. It is thought to participate in the formation of a labile disulfide bond possibly with the CX6CC motif present in the transmembrane protein. Isomerization of the intersubunit disulfide bond to an SU intrachain disulfide bond is thought to occur upon receptor recognition in order to allow membrane fusion (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Gamma type-C retroviral envelope protein family
uniprot
proteins
protein_family
HERV class-I R env subfamily
uniprot
proteins
pubmed
10427470
uniprot
proteins
pubmed
10692254
uniprot
proteins
pubmed
12083821
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
12970426
uniprot
proteins
pubmed
14557543
uniprot
proteins
pubmed
3840930
uniprot
proteins
pubmed
7645262
uniprot
proteins
pubmed
9525678
uniprot
proteins
sequence_length
604
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Virion.
uniprot
proteins