DYRK1B
entrez
9149
canonical
uniprot
Q9Y463
canonical
ensembl
ENSG00000105204
resolver
ensembl
ENSG00000281320
resolver
ensp
ENSP00000221803
resolver
ensp
ENSP00000312789
resolver
ensp
ENSP00000403182
resolver
ensp
ENSP00000469863
resolver
ensp
ENSP00000796132
resolver
enst
ENST00000593685
resolver
genesymbol
DYRK1B
resolver
genesymbol_syn
MIRK
resolver
hgnc
HGNC:3092
resolver
uniprot
A0A9H4CVU7
resolver
uniprot
O75258
resolver
uniprot
O75788
resolver
uniprot
O75789
resolver
uniprot_entry
A0A9H4CVU7_HUMAN
resolver
uniprot_entry
DYR1B_HUMAN
resolver
uniprot_sec
O75258
resolver
uniprot_sec
O75788
resolver
uniprot_sec
O75789
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by RANBP9.
uniprot
proteins
amino_acid_sequence
MAVPPGHGPFSGFPGPQEHTQVLPDVRLLPRRLPLAFRDATSAPLRKLSVDLIKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLIGKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMFRNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQLCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGEPLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGGGWTLRRTKELRKDYQGPGTRRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADEATNTGPAGSSASTSPAPLDTCPSSSTASSISSSGGSSGSSSDNRTYRYSNRYCGGPGPPITDCEMNSPQVPPSQPLRPWAGGDVPHKTHQAPASASSLPGTGAQLPPQPRYLGRPPSPTSPPPPELMDVSLVGGPADCSPPHPAPAPQHPAASALRTRMTGGRPPLPPPDDPATLGPHLGLRGVPQSTAASS
uniprot
proteins
disease_involvement
DISEASE: Abdominal obesity-metabolic syndrome 3 (AOMS3) [MIM:615812]: A form of abdominal obesity-metabolic syndrome, a disorder characterized by abdominal obesity, high triglycerides, low levels of high density lipoprotein cholesterol, high blood pressure, and elevated fasting glucose levels. AOMS3 is characterized by early-onset coronary artery disease, central obesity, hypertension, and diabetes. {ECO:0000269|PubMed:24827035}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.12.1
uniprot
proteins
function
FUNCTION: Dual-specificity kinase which possesses both serine/threonine and tyrosine kinase activities. Plays an essential role in ribosomal DNA (rDNA) double-strand break repair and rDNA copy number maintenance (PubMed:33469661). During DNA damage, mediates transcription silencing in part via phosphorylating and enforcing DSB accumulation of the histone methyltransferase EHMT2 (PubMed:32611815). Enhances the transcriptional activity of TCF1/HNF1A and FOXO1. Inhibits epithelial cell migration. Mediates colon carcinoma cell survival in mitogen-poor environments. Inhibits the SHH and WNT1 pathways, thereby enhancing adipogenesis. In addition, promotes expression of the gluconeogenic enzyme glucose-6-phosphatase catalytic subunit 1 (G6PC1). {ECO:0000269|PubMed:10910078, ECO:0000269|PubMed:11980910, ECO:0000269|PubMed:14500717, ECO:0000269|PubMed:24827035, ECO:0000269|PubMed:33469661}.
uniprot
proteins
mass_dalton
69198
uniprot
proteins
mutagenesis
MUTAGEN 140; /note="K->R: Abolishes kinase activity."; /evidence="ECO:0000269|PubMed:10910078"; MUTAGEN 239; /note="D->A: Abolishes kinase activity."; /evidence="ECO:0000269|PubMed:32611815"; MUTAGEN 271; /note="Y->F: Abolishes kinase activity; when associated with F-273."; /evidence="ECO:0000269|PubMed:10910078"; MUTAGEN 273; /note="Y->F: Abolishes kinase activity; when associated with F-271."; /evidence="ECO:0000269|PubMed:10910078
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated on tyrosine residues. Phosphorylated by MAP kinase. Tyrosine phosphorylation may be required for dimerization. {ECO:0000269|PubMed:10910078}.
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
MNB/DYRK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10910078
uniprot
proteins
pubmed
11980910
uniprot
proteins
pubmed
14500717
uniprot
proteins
pubmed
14593110
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
22998443
uniprot
proteins
pubmed
24827035
uniprot
proteins
pubmed
32611815
uniprot
proteins
pubmed
33469661
uniprot
proteins
pubmed
9918863
uniprot
proteins
sequence_length
629
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:32611815, ECO:0000269|PubMed:33469661}. Nucleus, nucleolus {ECO:0000269|PubMed:33469661}. Chromosome {ECO:0000269|PubMed:32611815}. Note=Localizes to sites of double-strand breaks (DSBs) following DNA damage. {ECO:0000269|PubMed:32611815}.
uniprot
proteins