Cbln2
entrez
12405
canonical
uniprot
Q8BGU2
canonical
ensembl
ENSMUSG00000024647
resolver
ensp
ENSMUSP00000068863
resolver
ensp
ENSMUSP00000113695
resolver
ensp
ENSMUSP00000113996
resolver
ensp
ENSMUSP00000126810
resolver
enst
ENSMUST00000068423
resolver
enst
ENSMUST00000122079
resolver
enst
ENSMUST00000122464
resolver
enst
ENSMUST00000169470
resolver
genesymbol
Cbln2
resolver
uniprot_entry
CBLN2_MOUSE
resolver
amino_acid_sequence
MPAPGQGPRGPLLSMPGRRGALREPADFGSSLGAVLALLLLLLPACCPVRAQNDTEPIVLEGKCLVVCDSSPSGDGAVTSSLGISVRSGSAKVAFSATRSTNHEPSEMSNRTMTIYFDQVLVNIGNHFDLASSIFVAPRKGIYSFSFHVVKVYNRQTIQVSLMQNGYPVISAFAGDQDVTREAASNGVLLLMEREDKVHLKLERGNLMGGWKYSTFSGFLVFPL
uniprot
proteins
function
FUNCTION: Acts as a synaptic organizer in specific subsets of neurons in the brain (PubMed:21410790, PubMed:29691328). Essential for long-term maintenance but not establishment of excitatory synapses (PubMed:29691328, PubMed:30287486). Functions as part of a trans-synaptic complex by binding to postsynaptic GRID1 and presynaptic neurexins. This interaction helps regulate the activity of NMDA and AMPA receptors at hippocampal synapses without affecting synapse formation. NRXN1B-CBLN2-GRID1 complex transduce presynaptic signals into postsynaptic NMDAR response. NRXN3B-CBLN2-GRID1 complex transduce presynaptic signals into postsynaptic AMPAR response (PubMed:34135511). {ECO:0000269|PubMed:21410790, ECO:0000269|PubMed:29691328, ECO:0000269|PubMed:30287486, ECO:0000269|PubMed:34135511}.
uniprot
proteins
mass_dalton
24051
uniprot
proteins
mutagenesis
MUTAGEN 53; /note="N->Q: No effect on its ability to form homohexameric or heteromeric complexes with other CBLN family members. Increased interaction with NRXN1 and NRXN3. Total loss of N-glycosylation; when associated with Q-110."; /evidence="ECO:0000269|PubMed:17331201, ECO:0000269|PubMed:29782851"; MUTAGEN 110; /note="N->Q: No effect on its ability to form homohexameric or heteromeric complexes with other CBLN family members. Increased interaction with NRXN1. Total loss of N-glycosylation; when associated with Q-53."; /evidence="ECO:0000269|PubMed:17331201, ECO:0000269|PubMed:29782851
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16930405
uniprot
proteins
pubmed
17030622
uniprot
proteins
pubmed
17331201
uniprot
proteins
pubmed
21410790
uniprot
proteins
pubmed
22220752
uniprot
proteins
pubmed
29691328
uniprot
proteins
pubmed
29782851
uniprot
proteins
pubmed
30287486
uniprot
proteins
pubmed
34135511
uniprot
proteins
sequence_length
224
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17030622, ECO:0000269|PubMed:17331201, ECO:0000269|PubMed:29782851, ECO:0000269|PubMed:34135511}.
uniprot
proteins