Ddi2
entrez
68817
canonical
uniprot
A2ADY9
canonical
ensembl
ENSMUSG00000078515
resolver
ensp
ENSMUSP00000099542
resolver
ensp
ENSMUSP00000160094
resolver
enst
ENSMUST00000102484
resolver
enst
ENSMUST00000250008
resolver
genesymbol
Ddi2
resolver
uniprot
A0ABA7IXH8
resolver
uniprot_entry
A0ABA7IXH8_MOUSE
resolver
uniprot_entry
DDI2_MOUSE
resolver
amino_acid_sequence
MLLTVYCVRRDLSEVTFSLQVDADFELHNFRALCELESGIPAAESQIVYAERPLTDNHRSLASYGLKDGDVVILRQKENADPRPAVQFSNLPRIDFSSIAVPGTSNPQQRQLPRTQAQHSSPGEMASSPQGLDNPALLRDMLLANPHELSLLKERNPPLAEALLSGDLEKFSRVLVEQQQDRARREQERIRLFSADPFDLEAQAKIEEDIRQQNIEENMTIAMEEAPESFGQVAMLYINCRVNGHPVKAFVDSGAQMTIMSQACAERCNIMRLVDRRWAGIAKGVGTQKIIGRVHLAQVQIEGDFLACSFSILEEQPMDMLLGLDMLKRHQCSIDLKKNVLVIGTTGSQTTFLPEGELPECARLAYGTGREDIRPEEIADQELAEAIQKSAEDAERQKP
uniprot
proteins
ec_number
3.4.23.-
uniprot
proteins
function
FUNCTION: Aspartic protease that mediates the cleavage of NFE2L1/NRF1 at 'Leu-104', thereby promoting release of NFE2L1/NRF1 from the endoplasmic reticulum membrane. Ubiquitination of NFE2L1/NRF1 is a prerequisite for cleavage, suggesting that DDI2 specifically recognizes and binds ubiquitinated NFE2L1/NRF1. Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2. Required, with DDI1, for cellular survival following replication stress. Together or redundantly with DDI1, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity. {ECO:0000250|UniProtKB:Q5TDH0}.
uniprot
proteins
mass_dalton
44591
uniprot
proteins
protein_family
DDI1 family
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
399
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q5TDH0}. Chromosome {ECO:0000250|UniProtKB:Q5TDH0}.
uniprot
proteins