NRXN3
entrez
9369
canonical
uniprot
Q9HDB5
canonical
uniprot
Q9Y4C0
canonical
ensembl
ENSG00000021645
resolver
ensp
ENSP00000281127
resolver
ensp
ENSP00000338349
resolver
ensp
ENSP00000394426
resolver
ensp
ENSP00000450683
resolver
ensp
ENSP00000451648
resolver
ensp
ENSP00000451672
resolver
ensp
ENSP00000488920
resolver
enst
ENST00000335750
resolver
enst
ENST00000634499
resolver
genesymbol
NRXN3
resolver
genesymbol_syn
C14orf60
resolver
genesymbol_syn
KIAA0743
resolver
hgnc
HGNC:8010
resolver
uniprot
A0A0A0MR89
resolver
uniprot
A0A0U1RQC5
resolver
uniprot
A5PKW8
resolver
uniprot
A6NGR4
resolver
uniprot
A7MD34
resolver
uniprot
A8MPU5
resolver
uniprot
B3KPM7
resolver
uniprot
O95378
resolver
uniprot
Q6NUR0
resolver
uniprot
Q8IUD8
resolver
uniprot
Q8IUE3
resolver
uniprot
Q9NS47
resolver
uniprot
Q9P1V3
resolver
uniprot
Q9P1V6
resolver
uniprot
Q9UIE2
resolver
uniprot
Q9UIE3
resolver
uniprot
Q9ULA5
resolver
uniprot
Q9Y486
resolver
uniprot_entry
A0A0A0MR89_HUMAN
resolver
uniprot_entry
A0A0U1RQC5_HUMAN
resolver
uniprot_entry
NRX3A_HUMAN
resolver
uniprot_entry
NRX3B_HUMAN
resolver
uniprot_sec
A5PKW8
resolver
uniprot_sec
A6NGR4
resolver
uniprot_sec
A7MD34
resolver
uniprot_sec
A8MPU5
resolver
uniprot_sec
B3KPM7
resolver
uniprot_sec
O95378
resolver
uniprot_sec
Q6NUR0
resolver
uniprot_sec
Q8IUD8
resolver
uniprot_sec
Q8IUE3
resolver
uniprot_sec
Q9NS47
resolver
uniprot_sec
Q9P1V3
resolver
uniprot_sec
Q9P1V6
resolver
uniprot_sec
Q9UIE2
resolver
uniprot_sec
Q9UIE3
resolver
uniprot_sec
Q9ULA5
resolver
uniprot_sec
Q9Y486
resolver
amino_acid_sequence
MHLRIHARRSPPRRPAWTLGIWFLFWGCIVSSVWSSSNVASSSSTSSSPGSHSQHEHHFHGSKHHSVPISIYRSPVSLRGGHAGATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGGKDKGRLFQGQLSGLYYDGLKVLNMAAENNPNIKINGSVRLVGEVPSILGTTQTTSMPPEMSTTVMETTTTMATTTTRKNRSTASIQPTSDDLVSSAECSSDDEDFVECEPSTGGELVIPLLVEDPLATPPIATRAPSITLPPTFRPLLTIIETTKDSLSMTSEAGLPCLSDQGSDGCDDDGLVISGYGSGETFDSNLPPTDDEDFYTTFSLVTDKSLSTSIFEGGYKAHAPKWESKDFRPNKVSETSRTTTTSLSPELIRFTASSSSGMVPKLPAGKMNNRDLKPQPDIVLLPLPTAYELDSTKLKSPLITSPMFRNVPTANPTEPGIRRVPGASEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRNYISNSAQSNGTLMKEKQQSSKSGHKKQKNKDREYYV
uniprot
proteins
amino_acid_sequence
MSSTLHSVFFTLKVSILLGSLLGLCLGLEFMGLPNQWARYLRWDASTRSDLSFQFKTNVSTGLLLYLDDGGVCDFLCLSLVDGRVQLRFSMDCAETAVLSNKQVNDSSWHFLMVSRDRLRTVLMLDGEGQSGELQPQRPYMDVVSDLFLGGVPTDIRPSALTLDGVQAMPGFKGLILDLKYGNSEPRLLGSRGVQMDAEGPCGERPCENGGICFLLDGHPTCDCSTTGYGGKLCSEDVSQDPGLSHLMMSEQAREENVATFRGSEYLCYDLSQNPIQSSSDEITLSFKTWQRNGLILHTGKSADYVNLALKDGAVSLVINLGSGAFEAIVEPVNGKFNDNAWHDVKVTRNLRQVTISVDGILTTTGYTQEDYTMLGSDDFFYVGGSPSTADLPGSPVSNNFMGCLKEVVYKNNDIRLELSRLARIADTKMKIYGEVVFKCENVATLDPINFETPEAYISLPKWNTKRMGSISFDFRTTEPNGLILFTHGKPQERKDARSQKNTKVDFFAVELLDGNLYLLLDMGSGTIKVKATQKKANDGEWYHVDIQRDGRSGTISVNSRRTPFTASGESEILDLEGDMYLGGLPENRAGLILPTELWTAMLNYGYVGCIRDLFIDGRSKNIRQLAEMQNAAGVKSSCSRMSAKQCDSYPCKNNAVCKDGWNRFICDCTGTGYWGRTCEREASILSYDGSMYMKIIMPMVMHTEAEDVSFRFMSQRAYGLLVATTSRDSADTLRLELDGGRVKLMVNLDCIRINCNSSKGPETLYAGQKLNDNEWHTVRVVRRGKSLKLTVDDDVAEGTMVGDHTRLEFHNIETGIMTEKRYISVVPSSFIGHLQSLMFNGLLYIDLCKNGDIDYCELKARFGLRNIIADPVTFKTKSSYLSLATLQAYTSMHLFFQFKTTSPDGFILFNSGDGNDFIAVELVKGYIHYVFDLGNGPNVIKGNSDRPLNDNQWHNVVITRDNSNTHSLKVDTKVVTQVINGAKNLDLKGDLYMAGLAQGMYSNLPKLVASRDGFQGCLASVDLNGRLPDLINDALHRSGQIERGCEGPSTTCQEDSCANQGVCMQQWEGFTCDCSMTSYSGNQCNDPGATYIFGKSGGLILYTWPANDRPSTRSDRLAVGFSTTVKDGILVRIDSAPGLGDFLQLHIEQGKIGVVFNIGTVDISIKEERTPVNDGKYHVVRFTRNGGNATLQVDNWPVNEHYPTGRQLTIFNTQAQIAIGGKDKGRLFQGQLSGLYYDGLKVLNMAAENNPNIKINGSVRLVGEVPSILGTTQTTSMPPEMSTTVMETTTTMATTTTRKNRSTASIQPTSDDLVSSAECSSDDEDFVECEPSTTGGELVIPLLVEDPLATPPIATRAPSITLPPTFRPLLTIIETTKDSLSMTSEAGLPCLSDQGSDGCDDDGLVISGYGSGETFDSNLPPTDDEDFYTTFSLVTDKSLSTSIFEGGYKAHAPKWESKDFRPNKVSETSRTTTTSLSPELIRFTASSSSGMVPKLPAGKMNNRDLKPQPDIVLLPLPTAYELDSTKLKSPLITSPMFRNVPTANPTEPGIRRVPGASEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDETRNYISNSAQSNGTLMKEKQQSSKSGHKKQKNKDREYYV
uniprot
proteins
function
FUNCTION: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling (By similarity). Functions as part of a trans-synaptic complex by binding to cerebellins and postsynaptic GRID1. This interaction helps regulate the activity of NMDA and AMPA receptors at hippocampal synapses without affecting synapse formation. NRXN3B-CBLN2-GRID1 complex transduce presynaptic signals into postsynaptic AMPAR response (By similarity). {ECO:0000250|UniProtKB:Q8C985, ECO:0000250|UniProtKB:Q9CS84}.
uniprot
proteins
function
FUNCTION: Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling (By similarity). {ECO:0000250|UniProtKB:Q9CS84}.
uniprot
proteins
mass_dalton
180599
uniprot
proteins
mass_dalton
69305
uniprot
proteins
post_translational_modification
PTM: O-glycosylated; contains heparan sulfate. Heparan sulfate attachment is required for synapse development by mediating interactions with neuroligins. {ECO:0000250|UniProtKB:Q6P9K9}.
uniprot
proteins
post_translational_modification
PTM: Processed by alpha-secretase leading to the formation of an extracellular soluble protein as well as a C-terminal membrane-embedded fragment (CTF). Proteolysis of these CTFs by gamma-secretase releases intracellular domains (ICDs) and extracellular peptides. {ECO:0000269|PubMed:21084300}.; PTM: O-glycosylated; contains heparan sulfate. Heparan sulfate attachment is required for synapse development by mediating interactions with neuroligins. {ECO:0000250|UniProtKB:Q8C985}.
uniprot
proteins
protein_family
Neurexin family
uniprot
proteins
pubmed
11944992
uniprot
proteins
pubmed
12379233
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19926856
uniprot
proteins
pubmed
21084300
uniprot
proteins
pubmed
9872452
uniprot
proteins
sequence_length
1643
uniprot
proteins
sequence_length
637
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Presynaptic cell membrane {ECO:0000250|UniProtKB:Q8C985}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Presynaptic cell membrane {ECO:0000250|UniProtKB:Q9CS84}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 1569..1589; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins
transmembrane_region
TRANSMEM 563..583; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins