Bdnf
entrez
24225
canonical
uniprot
P23363
canonical
ensembl
ENSRNOG00000047466
resolver
ensembl
ENSRNOG00055023387
resolver
ensembl
ENSRNOG00060001681
resolver
ensembl
ENSRNOG00065016064
resolver
ensp
ENSRNOP00000064356
resolver
ensp
ENSRNOP00000072315
resolver
ensp
ENSRNOP00000072849
resolver
ensp
ENSRNOP00000073265
resolver
ensp
ENSRNOP00000073647
resolver
ensp
ENSRNOP00000073685
resolver
ensp
ENSRNOP00000074338
resolver
ensp
ENSRNOP00000075479
resolver
ensp
ENSRNOP00000104100
resolver
ensp
ENSRNOP00055032626
resolver
ensp
ENSRNOP00055032659
resolver
ensp
ENSRNOP00055032687
resolver
ensp
ENSRNOP00055032692
resolver
ensp
ENSRNOP00055032703
resolver
ensp
ENSRNOP00055032715
resolver
ensp
ENSRNOP00060001682
resolver
ensp
ENSRNOP00060001691
resolver
ensp
ENSRNOP00060001703
resolver
ensp
ENSRNOP00060001706
resolver
ensp
ENSRNOP00060001708
resolver
ensp
ENSRNOP00060001714
resolver
ensp
ENSRNOP00065020948
resolver
ensp
ENSRNOP00065020974
resolver
ensp
ENSRNOP00065020997
resolver
ensp
ENSRNOP00065021001
resolver
ensp
ENSRNOP00065021005
resolver
ensp
ENSRNOP00065021016
resolver
enst
ENSRNOT00000073636
resolver
enst
ENSRNOT00000077703
resolver
enst
ENSRNOT00000078543
resolver
enst
ENSRNOT00000080190
resolver
enst
ENSRNOT00000083289
resolver
enst
ENSRNOT00000083542
resolver
enst
ENSRNOT00000089233
resolver
enst
ENSRNOT00000090445
resolver
enst
ENSRNOT00000122945
resolver
enst
ENSRNOT00055040184
resolver
enst
ENSRNOT00055040219
resolver
enst
ENSRNOT00055040247
resolver
enst
ENSRNOT00055040253
resolver
enst
ENSRNOT00055040264
resolver
enst
ENSRNOT00055040276
resolver
enst
ENSRNOT00060002562
resolver
enst
ENSRNOT00060002573
resolver
enst
ENSRNOT00060002593
resolver
enst
ENSRNOT00060002598
resolver
enst
ENSRNOT00060002602
resolver
enst
ENSRNOT00060002608
resolver
enst
ENSRNOT00065026701
resolver
enst
ENSRNOT00065026727
resolver
enst
ENSRNOT00065026750
resolver
enst
ENSRNOT00065026754
resolver
enst
ENSRNOT00065026758
resolver
enst
ENSRNOT00065026769
resolver
genesymbol
Bdnf
resolver
uniprot
A0A0G2K624
resolver
uniprot
A0A0H2UI28
resolver
uniprot
A0ABK0LQJ4
resolver
uniprot
Q53YL8
resolver
uniprot_entry
A0A0G2K624_RAT
resolver
uniprot_entry
A0A0H2UI28_RAT
resolver
uniprot_entry
A0ABK0LQJ4_RAT
resolver
uniprot_entry
BDNF_RAT
resolver
uniprot_sec
Q53YL8
resolver
amino_acid_sequence
MTILFLTMVISYFGCMKAAPMKEANVHGQGNLAYPAVRTHGTLESVNGPRAGSRGLTTTSLADTFEHVIEELLDEDQKVRPNEENHKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCTLTIKRGR
uniprot
proteins
function
FUNCTION: Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability (By similarity). {ECO:0000250|UniProtKB:P21237, ECO:0000250|UniProtKB:P23560}.; FUNCTION: [Neurotrophic factor BDNF precursor form]: Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2. Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse. {ECO:0000250|UniProtKB:P21237}.
uniprot
proteins
mass_dalton
28109
uniprot
proteins
post_translational_modification
PTM: [Neurotrophic factor BDNF precursor form]: N-glycosylated and glycosulfated, contrary to mature BDNF. {ECO:0000250|UniProtKB:P23560}.; PTM: Mature BDNF is produced by proteolytic removal of the propeptide, catalyzed by a FURIN family member. In addition, the precursor form is proteolytically cleaved within the propeptide, but this is not an obligatory intermediate for the production of mature BDNF. Can be converted into mature BDNF by plasmin (PLG). {ECO:0000250|UniProtKB:P23560}.
uniprot
proteins
protein_family
NGF-beta family
uniprot
proteins
pubmed
1446835
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16376315
uniprot
proteins
pubmed
17149751
uniprot
proteins
pubmed
1889806
uniprot
proteins
pubmed
1966766
uniprot
proteins
pubmed
2025430
uniprot
proteins
pubmed
8461137
uniprot
proteins
sequence_length
249
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P23560}.; SUBCELLULAR LOCATION: [Neurotrophic factor BDNF precursor form]: Secreted {ECO:0000250|UniProtKB:P23560}. Note=A proportion of BDNF is secreted as immature precursor (proBDNF). {ECO:0000250|UniProtKB:P23560}.
uniprot
proteins