Nenf
entrez
289380
canonical
uniprot
Q6IUR5
canonical
ensembl
ENSRNOG00000003833
resolver
ensembl
ENSRNOG00055011249
resolver
ensembl
ENSRNOG00060013731
resolver
ensembl
ENSRNOG00065003995
resolver
ensp
ENSRNOP00000102526
resolver
ensp
ENSRNOP00055015354
resolver
ensp
ENSRNOP00060018585
resolver
ensp
ENSRNOP00065004190
resolver
enst
ENSRNOT00055019058
resolver
enst
ENSRNOT00060023428
resolver
enst
ENSRNOT00065005824
resolver
genesymbol
Nenf
resolver
genesymbol_syn
Scirp10
resolver
uniprot_entry
NENF_RAT
resolver
amino_acid_sequence
MARPAPWWWLRPLAALALALALVRVPSARAGQMPRPAERGPPVRLFTEEELARYSGEEEDQPIYLAVKGVVFDVTSGKEFYGRGAPYNALAGKDSSRGVAKMSLDPADLTHDISGLTAKELEALDDIFSKVYKAKYPIVGYTARRILNEDGSPNLDFKPEDQPHFDIKDEF
uniprot
proteins
function
FUNCTION: Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival (PubMed:31536960). Promotes cell proliferation and neurogenesis in undifferentiated neural progenitor cells at the embryonic stage and inhibits differentiation of astrocytes (By similarity). Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways (By similarity). Neurotrophic activity is enhanced by binding to heme (By similarity). Also acts as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity). {ECO:0000250|UniProtKB:Q9CQ45, ECO:0000269|PubMed:31536960}.
uniprot
proteins
mass_dalton
18992
uniprot
proteins
protein_family
Cytochrome b5 family
uniprot
proteins
protein_family
MAPR subfamily
uniprot
proteins
pubmed
31536960
uniprot
proteins
sequence_length
171
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000250|UniProtKB:Q9CQ45}. Mitochondrion {ECO:0000269|PubMed:31536960}. Endoplasmic reticulum {ECO:0000269|PubMed:31536960}. Note=Localized to mitochondria and endoplasmic reticulum by PINK1 and PARK7. {ECO:0000250|UniProtKB:Q9UMX5}.
uniprot
proteins