H2BC1
entrez
255626
canonical
uniprot
Q96A08
canonical
ensembl
ENSG00000146047
resolver
ensp
ENSP00000274764
resolver
enst
ENST00000274764
resolver
genesymbol
H2BC1
resolver
genesymbol_syn
HIST1H2BA
resolver
genesymbol_syn
TSH2B
resolver
hgnc
HGNC:18730
resolver
uniprot
B2R544
resolver
uniprot
Q6NZ98
resolver
uniprot
Q6NZA0
resolver
uniprot
Q6NZA1
resolver
uniprot_entry
H2B1A_HUMAN
resolver
uniprot_sec
B2R544
resolver
uniprot_sec
Q6NZ98
resolver
uniprot_sec
Q6NZA0
resolver
uniprot_sec
Q6NZA1
resolver
amino_acid_sequence
MPEVSSKGATISKKGFKKAVVKTQKKEGKKRKRTRKESYSIYIYKVLKQVHPDTGISSKAMSIMNSFVTDIFERIASEASRLAHYSKRSTISSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK
uniprot
proteins
function
FUNCTION: Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells (By similarity). Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones (By similarity). Core component of nucleosome (By similarity). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (By similarity). Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (By similarity). DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity). Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear (PubMed:21249133). {ECO:0000250|UniProtKB:P70696, ECO:0000269|PubMed:21249133}.
uniprot
proteins
mass_dalton
14167
uniprot
proteins
post_translational_modification
PTM: Monoubiquitination at Lys-36 (H2BK34Ub) by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination at Lys-122 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons. {ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:16713563}.; PTM: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. {ECO:0000269|PubMed:21925322}.; PTM: Acetylated during spermatogenesis. Acetylated form is most abundant in spermatogonia compared to spermatocytes and round spermatids (By similarity). {ECO:0000250|UniProtKB:Q00729}.; PTM: Phosphorylated at Thr-117 in spermatogonia, spermatocytes and round spermatids. {ECO:0000250|UniProtKB:Q00729}.; PTM: Methylated at Lys-118 in spermatogonia, spermatocytes and round spermatids. {ECO:0000250|UniProtKB:Q00729}.; PTM: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. {ECO:0000269|PubMed:31645732}.
uniprot
proteins
protein_family
Histone H2B family
uniprot
proteins
pubmed
12213818
uniprot
proteins
pubmed
12408966
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16283522
uniprot
proteins
pubmed
16307923
uniprot
proteins
pubmed
16713563
uniprot
proteins
pubmed
21249133
uniprot
proteins
pubmed
21726816
uniprot
proteins
pubmed
21925322
uniprot
proteins
pubmed
31645732
uniprot
proteins
sequence_length
127
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P70696}. Chromosome {ECO:0000250|UniProtKB:P70696}.
uniprot
proteins