Sptssa
entrez
104725
canonical
uniprot
Q8R207
canonical
ensembl
ENSMUSG00000044408
resolver
ensp
ENSMUSP00000053671
resolver
enst
ENSMUST00000056228
resolver
genesymbol
Sptssa
resolver
genesymbol_syn
Ssspta
resolver
uniprot
Q8BHT2
resolver
uniprot_entry
SPTSA_MOUSE
resolver
uniprot_sec
Q8BHT2
resolver
amino_acid_sequence
MAGMALARAWKQMSWFYYQYLLVTALYMLEPWERTVFNSMLVSVVGMALYTGYVFMPQHIMAILHYFEIVQ
uniprot
proteins
function
FUNCTION: Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. Within the SPT complex, SPTSSA stimulates the catalytic activity and plays a role in substrate specificity, which depends upon the overall complex composition. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. Independently of its action as a SPT component, may be involved in MBOAT7 localization to mitochondria-associated membranes, a membrane bridge between the endoplasmic reticulum and mitochondria, may hence affect MBOAT7-catalyzed incorporation of arachidonic acid into phosphatidylinositol. {ECO:0000250|UniProtKB:Q969W0}.
uniprot
proteins
mass_dalton
8452
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; sphingolipid metabolism.
uniprot
proteins
protein_family
SPTSS family
uniprot
proteins
protein_family
SPTSSA subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
71
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 35..57; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins