DVL2
entrez
1856
canonical
uniprot
O14641
canonical
ensembl
ENSG00000004975
resolver
ensp
ENSP00000005340
resolver
ensp
ENSP00000600277
resolver
ensp
ENSP00000657673
resolver
enst
ENST00000005340
resolver
genesymbol
DVL2
resolver
hgnc
HGNC:3086
resolver
uniprot
D3DTN3
resolver
uniprot
Q53XM0
resolver
uniprot_entry
DVL2_HUMAN
resolver
uniprot_sec
D3DTN3
resolver
uniprot_sec
Q53XM0
resolver
amino_acid_sequence
MAGSSTGGGGVGETKVIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWLVSSDNPQPEMAPPVHEPRAELAPPAPPLPPLPPERTSGIGDSRPPSFHPNVSSSHENLEPETETESVVSLRRERPRRRDSSEHGAGGHRTGGPSRLERHLAGYESSSTLMTSELESTSLGDSDEEDTMSRFSSSTEQSSASRLLKRHRRRRKQRPPRLERTSSFSSVTDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDMNFENMSNDDAVRVLRDIVHKPGPIVLTVAKCWDPSPQAYFTLPRNEPIQPIDPAAWVSHSAALTGTFPAYPGSSSMSTITSGSSLPDGCEGRGLSVHTDMASVTKAMAAPESGLEVRDRMWLKITIPNAFLGSDVVDWLYHHVEGFPERREARKYASGLLKAGLIRHTVNKITFSEQCYYVFGDLSGGCESYLVNLSLNDNDGSSGASDQDTLAPLPGATPWPLLPTFSYQYPAPHPYSPQPPPYHELSSYTYGGGSASSQHSEGSRSSGSTRSDGGAGRTGRPEERAPESKSGSGSESEPSSRGGSLRRGGEASGTSDGGPPPSRGSTGGAPNLRAHPGLHPYGPPPGMALPYNPMMVVMMPPPPPPVPPAVQPPGAPPVRDLGSVPPELTASRQSFHMAMGNPSEFFVDVM
uniprot
proteins
function
FUNCTION: Plays a role in the signal transduction pathways mediated by multiple Wnt genes (PubMed:24616100). Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:19252499, ECO:0000269|PubMed:24616100}.
uniprot
proteins
mass_dalton
78948
uniprot
proteins
mutagenesis
MUTAGEN 250..252; /note="TSS->AAA: Almost abolishes interaction with FOXK2."; /evidence="ECO:0000269|PubMed:25805136"; MUTAGEN 250; /note="T->A: No effect on interaction with FOXK2."; /evidence="ECO:0000269|PubMed:25805136"; MUTAGEN 251; /note="S->A: No effect on interaction with FOXK2."; /evidence="ECO:0000269|PubMed:25805136"; MUTAGEN 252; /note="S->A: Almost abolishes interaction with FOXK2."; /evidence="ECO:0000269|PubMed:25805136"; MUTAGEN 254..257; /note="SSVT->AAVA: Almost abolishes interaction with FOXK2."; /evidence="ECO:0000269|PubMed:25805136"; MUTAGEN 254; /note="S->A: Reduces interaction with FOXK2."; /evidence="ECO:0000269|PubMed:25805136"; MUTAGEN 255; /note="S->A: Almost abolishes interaction with FOXK2."; /evidence="ECO:0000269|PubMed:25805136"; MUTAGEN 257; /note="T->A: Almost abolishes interaction with FOXK2."; /evidence="ECO:0000269|PubMed:25805136"; MUTAGEN 259..262; /note="STMS->AAMA: Almost abolishes interaction with FOXK2."; /evidence="ECO:0000269|PubMed:25805136"; MUTAGEN 259; /note="S->A: Almost abolishes interaction with FOXK2."; /evidence="ECO:0000269|PubMed:25805136"; MUTAGEN 260; /note="T->A: No effect on interaction with FOXK2."; /evidence="ECO:0000269|PubMed:25805136"; MUTAGEN 262; /note="S->A: Almost abolishes interaction with FOXK2."; /evidence="ECO:0000269|PubMed:25805136"; MUTAGEN 267..269; /note="TVT->AVA: Almost abolishes interaction with FOXK2."; /evidence="ECO:0000269|PubMed:25805136"; MUTAGEN 267; /note="T->A: Almost abolishes interaction with FOXK2."; /evidence="ECO:0000269|PubMed:25805136"; MUTAGEN 269; /note="T->A: Almost abolishes interaction with FOXK2."; /evidence="ECO:0000269|PubMed:25805136"; MUTAGEN 275; /note="Y->F: No effect on interaction with FOXK2."; /evidence="ECO:0000269|PubMed:25805136"; MUTAGEN 281; /note="S->A: No effect on interaction with FOXK2."; /evidence="ECO:0000269|PubMed:25805136"; MUTAGEN 286; /note="S->A: No effect on interaction with FOXK2."; /evidence="ECO:0000269|PubMed:25805136"; MUTAGEN 295; /note="Y->F: No effect on interaction with FOXK2."; /evidence="ECO:0000269|PubMed:25805136"; MUTAGEN 298; /note="S->A: No effect on interaction with FOXK2."; /evidence="ECO:0000269|PubMed:25805136"; MUTAGEN 329; /note="S->A: No effect on interaction with FOXK2."; /evidence="ECO:0000269|PubMed:25805136
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CSNK1D (PubMed:21422228, PubMed:9192851). WNT3A induces DVL2 phosphorylation by CSNK1E and MARK kinases (PubMed:25805136). {ECO:0000269|PubMed:21422228, ECO:0000269|PubMed:25805136, ECO:0000269|PubMed:9192851}.; PTM: Ubiquitinated via 'Lys-63'-linked polyubiquitin chains; leading to its autophagy-mediated degradation. {ECO:0000269|PubMed:24616100}.
uniprot
proteins
protein_family
DSH family
uniprot
proteins
pubmed
11742073
uniprot
proteins
pubmed
15262978
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19252499
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21248752
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21422228
uniprot
proteins
pubmed
22610794
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23708998
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24616100
uniprot
proteins
pubmed
25557784
uniprot
proteins
pubmed
25805136
uniprot
proteins
pubmed
27214281
uniprot
proteins
pubmed
9192851
uniprot
proteins
sequence_length
736
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q60838}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q60838}; Cytoplasmic side {ECO:0000250|UniProtKB:Q60838}. Cytoplasm, cytosol {ECO:0000269|PubMed:24616100}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q60838}. Nucleus {ECO:0000269|PubMed:25805136}. Note=Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity). Interaction with FOXK1 and FOXK2 induces nuclear translocation (PubMed:25805136). {ECO:0000250|UniProtKB:Q60838, ECO:0000269|PubMed:24616100, ECO:0000269|PubMed:25805136}.
uniprot
proteins