Calr
entrez
64202
canonical
uniprot
P18418
canonical
ensembl
ENSRNOG00000003029
resolver
ensembl
ENSRNOG00055007731
resolver
ensembl
ENSRNOG00060012624
resolver
ensembl
ENSRNOG00065010365
resolver
ensp
ENSRNOP00000004091
resolver
ensp
ENSRNOP00055010325
resolver
ensp
ENSRNOP00060016944
resolver
ensp
ENSRNOP00065012805
resolver
enst
ENSRNOT00000004091
resolver
enst
ENSRNOT00055012941
resolver
enst
ENSRNOT00060021445
resolver
enst
ENSRNOT00065016763
resolver
genesymbol
Calr
resolver
uniprot
P10452
resolver
uniprot_entry
CALR_RAT
resolver
uniprot_sec
P10452
resolver
amino_acid_sequence
MLLSVPLLLGLLGLAAADPAIYFKEQFLDGDAWTNRWVESKHKSDFGKFVLSSGKFYGDQEKDKGLQTSQDARFYALSARFEPFSNKGQTLVVQFTVKHEQNIDCGGGYVKLFPGGLDQKDMHGDSEYNIMFGPDICGPGTKKVHVIFNYKGKNVLINKDIRCKDDEFTHLYTLIVRPDNTYEVKIDNSQVESGSLEDDWDFLPPKKIKDPDAAKPEDWDERAKIDDPTDSKPEDWDKPEHIPDPDAKKPEDWDEEMDGEWEPPVIQNPEYKGEWKPRQIDNPDYKGTWIHPEIDNPEYSPDANIYAYDSFAVLGLDLWQVKSGTIFDNFLITNDEAYAEEFGNETWGVTKAAEKQMKDKQDEEQRLKEEEEDKKRKEEEEAEDKEDEDDRDEDEDEEDEKEEDEEDATGQAKDEL
uniprot
proteins
function
FUNCTION: Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export (By similarity). Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity). {ECO:0000250|UniProtKB:P27797, ECO:0000250|UniProtKB:P28491, ECO:0000250|UniProtKB:Q8K3H7}.
uniprot
proteins
mass_dalton
47995
uniprot
proteins
protein_family
Calreticulin family
uniprot
proteins
pubmed
11248044
uniprot
proteins
pubmed
11842220
uniprot
proteins
pubmed
12270713
uniprot
proteins
pubmed
12782144
uniprot
proteins
pubmed
1497655
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2241926
uniprot
proteins
pubmed
2395661
uniprot
proteins
pubmed
7876339
uniprot
proteins
pubmed
8251535
uniprot
proteins
pubmed
8453984
uniprot
proteins
sequence_length
416
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:12782144}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P27797}. Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P27797}. Cell surface {ECO:0000250|UniProtKB:P27797}. Sarcoplasmic reticulum lumen {ECO:0000250|UniProtKB:P28491}. Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000250|UniProtKB:Q8K3H7}. Cytolytic granule {ECO:0000250|UniProtKB:P27797}. Note=Also found in cell surface (T cells), cytosol and extracellular matrix. During oocyte maturation and after parthenogenetic activation accumulates in cortical granules. In pronuclear and early cleaved embryos localizes weakly to cytoplasm around nucleus and more strongly in the region near the cortex (By similarity). In cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation (By similarity). {ECO:0000250|UniProtKB:P27797, ECO:0000250|UniProtKB:P28491, ECO:0000250|UniProtKB:Q8K3H7}.
uniprot
proteins