Twf2
entrez
23999
canonical
uniprot
Q9Z0P5
canonical
ensembl
ENSMUSG00000023277
resolver
ensp
ENSMUSP00000024047
resolver
genesymbol
Twf2
resolver
genesymbol_syn
Ptk9l
resolver
uniprot
Q3TD06
resolver
uniprot
Q3TZG2
resolver
uniprot
Q8BN77
resolver
uniprot
Q9DCK8
resolver
uniprot_entry
TWF2_MOUSE
resolver
uniprot_sec
Q3TD06
resolver
uniprot_sec
Q3TZG2
resolver
uniprot_sec
Q8BN77
resolver
uniprot_sec
Q9DCK8
resolver
amino_acid_sequence
MAHQTGIHATEELKEFFAKARAGSIRLIKVIIEDEQLVLGASQEPVGRWDQDYDRAVLPLLDAQEPCYLLFRLDSQNAQGFEWLFLAWSPDNSPVRLKMLYAATRATVKKEFGGGHIKDELFGTVKDDLSLAGYQKHLSSCAAPAPLTSAERELQQIRINEVKTEISVESKHQTLQGLAFPLQPEAQRALQQLKQKTVNYIQLKLDLERETIELVHTEPTNVAQLPSRIPRDAARYHFFLYKHTHEGDALESVVFIYSMPGYKCSIKERMLYSSCKSRLLDSVEQDFQLEIAKKIEIGDGAELTAEFLYDEVHPKQHAFKQAFAKPKGPGGKRGHKRLIRGPGENGEDS
uniprot
proteins
function
FUNCTION: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia. {ECO:0000269|PubMed:18837697, ECO:0000269|PubMed:19955359}.
uniprot
proteins
mass_dalton
39471
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on both serine/threonine and tyrosine.
uniprot
proteins
protein_family
Actin-binding proteins ADF family
uniprot
proteins
protein_family
Twinfilin subfamily
uniprot
proteins
pubmed
10406962
uniprot
proteins
pubmed
12807912
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
18837697
uniprot
proteins
pubmed
19774077
uniprot
proteins
pubmed
19955359
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21876732
uniprot
proteins
sequence_length
349
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19955359}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10406962}. Cell projection, stereocilium {ECO:0000269|PubMed:19774077, ECO:0000269|PubMed:19955359}. Note=Perinuclear and G-actin-rich cortical actin structure sublocalization. Isoform 2 found also along myofibrils in cardiomyocytes (PubMed:18837697). Localized in cochlea hair cells to the tips of the middle and short rows of stereocilia (PubMed:19955359). {ECO:0000269|PubMed:18837697, ECO:0000269|PubMed:19955359}.
uniprot
proteins