Asic5
entrez
58170
canonical
uniprot
Q9R0Y1
canonical
ensembl
ENSMUSG00000028008
resolver
ensp
ENSMUSP00000029641
resolver
ensp
ENSMUSP00000103364
resolver
enst
ENSMUST00000029641
resolver
enst
ENSMUST00000107736
resolver
genesymbol
Asic5
resolver
genesymbol_syn
Accn5
resolver
uniprot
D3Z0S5
resolver
uniprot_entry
ASIC5_MOUSE
resolver
uniprot_entry
D3Z0S5_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by the diuretic drug amiloride (PubMed:20656685). Contrary to its rat ortholog it is not inhibited by Ca(2+) (PubMed:20656685). {ECO:0000269|PubMed:20656685}.
uniprot
proteins
amino_acid_sequence
MEHTEKSQVHAEKGLLGKIKRYLSKRPLPSPTDRKKFDQDFAMSTSFHGIHNIAQNQNKVRKVIWLAVVLGSVSLLVWQIYSRLVNYFTWPTTTSIEVQYVEKIEFPAVTLCNLNRFQTEAVSRFGIIFFLWDIVSKVLRLQEISANNTGSPETLDFVTNHQNFSITEFVKNNGFYLNNDTLVHCEFFGKTCSPKDFKHVFTEYGNCFTFNYGENIQNKNKVSVSGRGLKLLLDVHQEEFTDNPVPGFADAGVIFVIHSPKKEPQFDGLGLSSPVGMHARVTIRQLKTVHQEYPWGECNPNIKLRNFITYSTYGCLKECKARHIQRLCGCLPFLLPGNGVECDLLEYYNCVSPILDHIERKGLCTMGTHNSSCPVSCEETEYPATVSYSTFPSQRATRFLAKKLNQSQEYIRENLVNIEINYSDLNYKITQQQKAVSVPELLADVGGQLGLFCGASLITIIEIIEYFFTNFYWVLIFFLLKILETIQRTSPPQAV
uniprot
proteins
function
FUNCTION: Forms bile acid-gated sodium channels and may play a role in bile acid-dependent absorption and secretion by epithelial cells of the bile ducts (PubMed:20656685, PubMed:22735174). Displays high selectivity for sodium ions but can also permit the permeation of other cations (PubMed:20656685, PubMed:22735174). The gating could be indirect and the consequence of alterations of the membrane environment of the channel by bile acids (PubMed:20656685). As a sodium channel of type II unipolar brush cells of the vestibulocerebellum, controlling the electrical activity of these cells, could play a role in motor coordination and balance (PubMed:32034189). {ECO:0000269|PubMed:20656685, ECO:0000269|PubMed:22735174, ECO:0000269|PubMed:32034189}.
uniprot
proteins
mass_dalton
56523
uniprot
proteins
protein_family
ASIC5 subfamily
uniprot
proteins
protein_family
Amiloride-sensitive sodium channel (TC 1.A.6) family
uniprot
proteins
pubmed
10457052
uniprot
proteins
pubmed
20656685
uniprot
proteins
pubmed
22735174
uniprot
proteins
pubmed
24663811
uniprot
proteins
pubmed
25360526
uniprot
proteins
pubmed
32034189
uniprot
proteins
sequence_length
495
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q9R0W5}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9R0W5}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 62..82; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 460..480; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins