ACAA1
entrez
30
canonical
uniprot
P09110
canonical
ensembl
ENSG00000060971
resolver
ensp
ENSP00000301810
resolver
ensp
ENSP00000333664
resolver
ensp
ENSP00000625565
resolver
genesymbol
ACAA1
resolver
genesymbol_syn
ACAA
resolver
genesymbol_syn
PTHIO
resolver
hgnc
HGNC:82
resolver
uniprot
A0A024R2M6
resolver
uniprot
A0A140VJX0
resolver
uniprot
A0A384NL32
resolver
uniprot
G5E935
resolver
uniprot
Q96CA6
resolver
uniprot_entry
A0A024R2M6_HUMAN
resolver
uniprot_entry
A0A140VJX0_HUMAN
resolver
uniprot_entry
THIK_HUMAN
resolver
uniprot_sec
A0A384NL32
resolver
uniprot_sec
G5E935
resolver
uniprot_sec
Q96CA6
resolver
amino_acid_sequence
MQRLQVVLGHLRGPADSGWMPQAAPCLSGAPQASAADVVVVHGRRTAICRAGRGGFKDTTPDELLSAVMTAVLKDVNLRPEQLGDICVGNVLQPGAGAIMARIAQFLSDIPETVPLSTVNRQCSSGLQAVASIAGGIRNGSYDIGMACGVESMSLADRGNPGNITSRLMEKEKARDCLIPMGITSENVAERFGISREKQDTFALASQQKAARAQSKGCFQAEIVPVTTTVHDDKGTKRSITVTQDEGIRPSTTMEGLAKLKPAFKKDGSTTAGNSSQVSDGAAAILLARRSKAEELGLPILGVLRSYAVVGVPPDIMGIGPAYAIPVALQKAGLTVSDVDIFEINEAFASQAAYCVEKLRLPPEKVNPLGGAVALGHPLGCTGARQVITLLNELKRRGKRAYGVVSMCIGTGMGAAAVFEYPGN
uniprot
proteins
ec_number
2.3.1.155
uniprot
proteins
ec_number
2.3.1.16
uniprot
proteins
ec_number
2.3.1.9
uniprot
proteins
function
FUNCTION: Responsible for the thiolytic cleavage of straight chain 3-keto fatty acyl-CoAs (3-oxoacyl-CoAs) (PubMed:11734571, PubMed:2882519). Plays an important role in fatty acid peroxisomal beta-oxidation (PubMed:11734571, PubMed:2882519). Catalyzes the cleavage of medium, long, and very long straight chain 3-oxoacyl-CoAs (PubMed:11734571, PubMed:2882519). May play a role in peroxisomal beta-oxidation step in polyunsaturated fatty acids (PUFAs) biosynthesis. Possibly regulates systemic levels of docosahexaenoic acid (DHA, C22:6n-3) through a process involving endoplasmic reticulum desaturation and elongation of alpha-linolenic acid (ALA, C18:3n-3) to form tetracosahexaenoic acid (THA, C24:6n-3), which is then beta-oxidized to DHA in peroxisomes. {ECO:0000303|PubMed:10903473, ECO:0000303|PubMed:35951481, ECO:0000303|PubMed:7685190, ECO:0000305|PubMed:11734571, ECO:0000305|PubMed:2882519, ECO:0000305|PubMed:35951481}.
uniprot
proteins
mass_dalton
44292
uniprot
proteins
mutagenesis
MUTAGEN 5; /note="Q->D,K,L: Does not affect localization to peroxisomes."; /evidence="ECO:0000269|PubMed:22057399"; MUTAGEN 6; /note="V->D: Abolished localization to peroxisomes."; /evidence="ECO:0000269|PubMed:22057399"; MUTAGEN 6; /note="V->K: Does not affect localization to peroxisomes."; /evidence="ECO:0000269|PubMed:22057399"; MUTAGEN 7; /note="V->D,K: Abolished localization to peroxisomes."; /evidence="ECO:0000269|PubMed:22057399"; MUTAGEN 8; /note="L->D,K: Does not affect localization to peroxisomes."; /evidence="ECO:0000269|PubMed:22057399"; MUTAGEN 9; /note="G->D,R,L: Does not affect localization to peroxisomes."; /evidence="ECO:0000269|PubMed:22057399"; MUTAGEN 10; /note="H->E: In S3E mutant; Abolished localization to peroxisomes."; /evidence="ECO:0000269|PubMed:22057399
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; peroxisomal fatty acid beta-oxidation. {ECO:0000305|PubMed:11734571, ECO:0000305|PubMed:2882519}.
uniprot
proteins
protein_family
Thiolase family
uniprot
proteins
protein_family
Thiolase-like superfamily
uniprot
proteins
pubmed
10903473
uniprot
proteins
pubmed
11734571
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
1679347
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22057399
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25538232
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
2726492
uniprot
proteins
pubmed
2882519
uniprot
proteins
pubmed
3194209
uniprot
proteins
pubmed
35951481
uniprot
proteins
pubmed
7685190
uniprot
proteins
sequence_length
424
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:22057399, ECO:0000269|PubMed:25538232}. Note=Transported into peroxisomes following association with PEX7. {ECO:0000269|PubMed:22057399, ECO:0000269|PubMed:25538232}.
uniprot
proteins