Cdk12
entrez
192350
canonical
uniprot
Q3MJK5
canonical
ensembl
ENSRNOG00000006000
resolver
ensp
ENSRNOP00000008256
resolver
ensp
ENSRNOP00000087177
resolver
ensp
ENSRNOP00000092388
resolver
ensp
ENSRNOP00000105670
resolver
enst
ENSRNOT00000008256
resolver
enst
ENSRNOT00000105342
resolver
enst
ENSRNOT00000114817
resolver
genesymbol
Cdk12
resolver
genesymbol_syn
Crk7
resolver
genesymbol_syn
Crkrs
resolver
genesymbol_syn
Pksc
resolver
uniprot
A0A8I6A3V7
resolver
uniprot
A0A8I6AHH6
resolver
uniprot
A0A8L2Q358
resolver
uniprot
Q8R458
resolver
uniprot_entry
A0A8I6A3V7_RAT
resolver
uniprot_entry
A0A8I6AHH6_RAT
resolver
uniprot_entry
A0A8L2Q358_RAT
resolver
uniprot_entry
CDK12_RAT
resolver
uniprot_sec
Q8R458
resolver
amino_acid_sequence
MPNSERHGGKKDGSGGASGTSQPSSGGGSSNSRERHRLVSKHKRHKSKHSKDMGLVTPEAASLGTIIKPLVEYDDISSDSDTFSDDMAFKSDRRENDERRGTDRSDRLHRHRHHQHRRSRDLLKTKQTEKEKNQEVSKSGSMKDRLSGSSKRSVEGNDDYGKAQLSKSSSKESRSSKMHKEKTRKERELKSGHKDRSKSHRKRETPKSYKTVDSPKRRSRSPHRKWSDSSKQDDSPSGASYGQDYDLSPPRSHTSSNYDSYKKSPGSTSRRQSISPPYKEPSAYQSSTRSPSPYSRRQRSVSPYSRRRSSSYERSGSYSGRSPSPYGRRRSSSPFLSKRSLSRSPISSRKSMKSRSRSPAYSRHSSSHSKKKRSGSRSRHSSISPVRLPLNSSLGAELSRKKKERAAAAAAAKLDGKESKGSPIILPKKEKFEVKESGLESKKLPRGIKSEKSTPDTELVNVAHSNTEVKNCLDTGKVKLDENLQKHPVKDLKAQGTKDTKPVALKEVIVTSKETETSEKEALPPLPTITSPPPLPSTTPPPQTPPLPPLPPLPAVPLQPPLPPPQPPFSQVPVSNTSTLPSSPHPRTSTLSSQTNSQPLVQVSMKTQLSVTAAIPHLKTSTLPPLPLPPLLPGDDDMDSPKEMLPSKPAKKEKEQRTRHLLTDLPLPPELPGGDPSPPDSPEPKAITPPQQPYKKRPKICCPRYGERRQTESDWGKRCVDKFDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLVHQSVVNMKEIVTDKQDALDFKKDKGAFYLVFEYMDHDLMGLLESGLVHFSEDHIKSFMKQLMEGLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYNSEESRPYTNKVITLWYRPPELLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIKLPYFNTMKPKKQYRRRLREEFSFIPSAALDLLDHMLTLDPSKRCTAEQTLQSDFLKDVELSKMAPPDLPHWQDCHELWSKKRRRQRQSGIVIEEQPPSKASRKETTSGTAAEPVKNSSPAPPQPAPVKAEPGPGDAVGLGDITQQLNQSELAVLLNLLQSQTDLSIPQMAQLLNIHSNPEMQQQLEALNQSISALTEASSQQQDSESIAPEESLKEVPSVSVVLPPAEQTTPEASNTPADMQNMLAVLLSQLMKTQEPAGNLEENTSDKNSGPQGPRRTPTMPQEEAAACPPHILPPEKRPPEPPGPPPPPPPPPLVEGDLSSAPQELNPAVTAALLQLLSQPEAEPPGHLPHEHQALRPMEYSTRSHPNRTYGNTDGPETGFSATDTDERSSGPALTESLVQTLVKNRTFSGSVSHLGESNSYQGTGSVQFPGDQDLRFTRVPLALHSVVGQPFLKSEGNSNSVVHAETKLQNYGELGPGTTGANSSGTTLQWGGPAQSFGKPYRGAARVPPRGGRGRGVPY
uniprot
proteins
ec_number
2.7.11.22
uniprot
proteins
ec_number
2.7.11.23
uniprot
proteins
function
FUNCTION: Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors (By similarity). Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. {ECO:0000250, ECO:0000269|PubMed:16537916}.
uniprot
proteins
mass_dalton
163790
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-889 increases kinase activity. {ECO:0000250}.
uniprot
proteins
protein_family
CDC2/CDKX subfamily
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
16537916
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
1484
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16537916}. Nucleus speckle {ECO:0000269|PubMed:16537916}. Note=Colocalized with nuclear speckles throughout interphase.
uniprot
proteins