HLA-DMA
entrez
3108
canonical
uniprot
P28067
canonical
ensembl
ENSG00000204257
resolver
ensembl
ENSG00000239463
resolver
ensembl
ENSG00000242361
resolver
ensembl
ENSG00000242685
resolver
ensembl
ENSG00000243189
resolver
ensembl
ENSG00000243215
resolver
ensembl
ENSG00000243719
resolver
ensp
ENSP00000363976
resolver
ensp
ENSP00000372717
resolver
ensp
ENSP00000392842
resolver
ensp
ENSP00000395349
resolver
ensp
ENSP00000404018
resolver
ensp
ENSP00000407198
resolver
ensp
ENSP00000410591
resolver
enst
ENST00000374843
resolver
enst
ENST00000383230
resolver
enst
ENST00000434337
resolver
enst
ENST00000441375
resolver
enst
ENST00000450601
resolver
enst
ENST00000452615
resolver
enst
ENST00000453490
resolver
genesymbol
HLA-DMA
resolver
genesymbol_syn
DMA
resolver
genesymbol_syn
RING6
resolver
hgnc
HGNC:4934
resolver
uniprot
O02966
resolver
uniprot
Q29639
resolver
uniprot
Q29640
resolver
uniprot
Q31604
resolver
uniprot
Q6ICR9
resolver
uniprot
Q96FA1
resolver
uniprot_entry
DMA_HUMAN
resolver
uniprot_entry
Q31604_HUMAN
resolver
uniprot_entry
Q6ICR9_HUMAN
resolver
uniprot_sec
O02966
resolver
uniprot_sec
Q29639
resolver
uniprot_sec
Q29640
resolver
uniprot_sec
Q96FA1
resolver
amino_acid_sequence
MGHEQNQGAALLQMLPLLWLLPHSWAVPEAPTPMWPDDLQNHTFLHTVYCQDGSPSVGLSEAYDEDQLFFFDFSQNTRVPRLPEFADWAQEQGDAPAILFDKEFCEWMIQQIGPKLDGKIPVSRGFPIAEVFTLKPLEFGKPNTLVCFVSNLFPPMLTVNWQHHSVPVEGFGPTFVSAVDGLSFQAFSYLNFTPEPSDIFSCIVTHEIDRYTAIAYWVPRNALPSDLLENVLCGVAFGLGVLGIIVGIVLIIYFRKPCSGD
uniprot
proteins
function
FUNCTION: Plays a critical role in catalyzing the release of class II-associated invariant chain peptide (CLIP) from newly synthesized MHC class II molecules and freeing the peptide binding site for acquisition of antigenic peptides. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. {ECO:0000269|PubMed:16547258, ECO:0000269|PubMed:23260142, ECO:0000269|PubMed:8849454, ECO:0000269|PubMed:9768757}.
uniprot
proteins
mass_dalton
29207
uniprot
proteins
mutagenesis
MUTAGEN 124; /note="R->A: Decreases the interaction with MHCII and peptide exchange; when associated with A-220."; /evidence="ECO:0000269|PubMed:23260142"; MUTAGEN 126; /note="F->A: Decreases the interaction with MHCII and peptide exchange."; /evidence="ECO:0000269|PubMed:23260142"; MUTAGEN 151; /note="N->A,R: Abrogates the interaction with MHCII and peptide exchange."; /evidence="ECO:0000269|PubMed:23260142"; MUTAGEN 199; /note="I->N: Decreases the interaction with MHCII and peptide exchange."; /evidence="ECO:0000269|PubMed:23260142"; MUTAGEN 220; /note="R->A: Decreases the interaction with MHCII and peptide exchange; when associated with A-124."; /evidence="ECO:0000269|PubMed:23260142
uniprot
proteins
protein_family
MHC class II family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
16547258
uniprot
proteins
pubmed
1922365
uniprot
proteins
pubmed
23260142
uniprot
proteins
pubmed
8026867
uniprot
proteins
pubmed
8225438
uniprot
proteins
pubmed
8849454
uniprot
proteins
pubmed
9768757
uniprot
proteins
sequence_length
261
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=Localizes to late endocytic compartment. Associates with lysosome membranes.
uniprot
proteins
transmembrane_region
TRANSMEM 234..254; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins