Supt4h1a
entrez
20922
canonical
uniprot
P63271
canonical
ensembl
ENSMUSG00000020485
resolver
ensp
ENSMUSP00000091487
resolver
enst
ENSMUST00000093955
resolver
genesymbol
Supt4h1a
resolver
genesymbol_syn
Spt4h
resolver
genesymbol_syn
Supt4a
resolver
genesymbol_syn
Supt4h
resolver
uniprot
B2KGH6
resolver
uniprot
Q16550
resolver
uniprot
Q3TIA2
resolver
uniprot
Q5NCP8
resolver
uniprot
Q5NCP9
resolver
uniprot
Q5NCQ0
resolver
uniprot
Q62387
resolver
uniprot_entry
SPT4A_MOUSE
resolver
uniprot_sec
B2KGH6
resolver
uniprot_sec
Q16550
resolver
uniprot_sec
Q3TIA2
resolver
uniprot_sec
Q5NCP8
resolver
uniprot_sec
Q5NCP9
resolver
uniprot_sec
Q5NCQ0
resolver
uniprot_sec
Q62387
resolver
amino_acid_sequence
MALETVPKDLRHLRACLLCSLVKTIDQFEYDGCDNCDAYLQMKGNREMVYDCTSSSFDGIIAMMSPEDSWVSKWQRVSNFKPGVYAVSVTGRLPQGIVRELKSRGVAYKSRDTAIKT
uniprot
proteins
function
FUNCTION: Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates mRNA processing and transcription elongation by RNA polymerase II. DSIF positively regulates mRNA capping by stimulating the mRNA guanylyltransferase activity of RNGTT/CAP1A. DSIF also acts cooperatively with the negative elongation factor complex (NELF complex) to enhance transcriptional pausing at sites proximal to the promoter. Transcriptional pausing may facilitate the assembly of an elongation competent RNA polymerase II complex. DSIF and NELF promote pausing by inhibition of the transcription elongation factor TFIIS/S-II. TFIIS/S-II binds to RNA polymerase II at transcription pause sites and stimulates the weak intrinsic nuclease activity of the enzyme. Cleavage of blocked transcripts by RNA polymerase II promotes the resumption of transcription from the new 3' terminus and may allow repeated attempts at transcription through natural pause sites (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
13193
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by Ubr5 when not assembled in the DSIF complex, leading to its degradation: Ubr5 recognizes and binds a degron that is not accessible when Supt4h1a is part of the DSIF complex. {ECO:0000250|UniProtKB:P63272}.
uniprot
proteins
protein_family
SPT4 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
8786137
uniprot
proteins
pubmed
9776760
uniprot
proteins
sequence_length
117
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins