Runx1
entrez
50662
canonical
uniprot
Q63046
canonical
ensembl
ENSRNOG00000001704
resolver
ensp
ENSRNOP00000002313
resolver
ensp
ENSRNOP00000070750
resolver
enst
ENSRNOT00000084134
resolver
genesymbol
Runx1
resolver
genesymbol_syn
Aml1
resolver
genesymbol_syn
Cbfa2
resolver
uniprot
A0A0G2JYQ4
resolver
uniprot_entry
A0A0G2JYQ4_RAT
resolver
uniprot_entry
RUNX1_RAT
resolver
amino_acid_sequence
MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDGGAALASKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSERLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQDARQIQPSPPWSYDQSYQYLGSITSSVHPATPISPGRASGMTSLSAELSSRLSTAPDLTAFGDPRQFPTLPSISDPRMHYPGAFTYSPPVTSGIGIGMSAMSSTSRYHTYLPPPYPGSSQAQAGPFQTGSPSYHLYYGTSAGSYQFSMVGGERSPPRILPPCTNASTGAALLNPSLPSQSDVVETEGSHSNSPTNMPPARLEEAVWRPY
uniprot
proteins
function
FUNCTION: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AML-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the BLK promoter. Inhibits KAT6B-dependent transcriptional activation. Controls the anergy and suppressive function of regulatory T-cells (Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regulates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells (By similarity). Positively regulates the expression of RORC in T-helper 17 cells (By similarity). {ECO:0000250|UniProtKB:Q01196, ECO:0000250|UniProtKB:Q03347}.
uniprot
proteins
mass_dalton
48556
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in its C-terminus upon IL-6 treatment. Phosphorylation enhances interaction with KAT6A (By similarity). {ECO:0000250}.; PTM: Methylated. {ECO:0000250}.; PTM: Phosphorylated in Ser-249 Thr-272 and Ser-275 by HIPK2 when associated with CBFB and DNA. This phosphorylation promotes subsequent EP300 phosphorylation (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7969143
uniprot
proteins
sequence_length
450
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins