RNASE6
entrez
6039
canonical
uniprot
Q93091
canonical
ensembl
ENSG00000169413
resolver
ensp
ENSP00000302046
resolver
ensp
ENSP00000575580
resolver
ensp
ENSP00000586223
resolver
enst
ENST00000304677
resolver
enst
ENST00000905521
resolver
enst
ENST00000916164
resolver
genesymbol
RNASE6
resolver
genesymbol_syn
RNS6
resolver
hgnc
HGNC:10048
resolver
uniprot
Q6IB39
resolver
uniprot_entry
Q6IB39_HUMAN
resolver
uniprot_entry
RNAS6_HUMAN
resolver
amino_acid_sequence
MVLCFPLLLLLLVLWGPVCPLHAWPKRLTKAHWFEIQHIQPSPLQCNRAMSGINNYTQHCKHQNTFLHDSFQNVAAVCDLLSIVCKNRRHNCHQSSKPVNMTDCRLTSGKYPQCRYSAAAQYKFFIVACDPPQKSDPPYKLVPVHLDSIL
uniprot
proteins
ec_number
3.1.27.-
uniprot
proteins
function
FUNCTION: Ribonuclease which shows a preference for the pyrimidines uridine and cytosine (PubMed:27013146, PubMed:8836175). Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli (PubMed:25075772, PubMed:27089320). Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria (PubMed:27089320). Probably contributes to urinary tract sterility (PubMed:25075772). Bactericidal activity is independent of RNase activity (PubMed:27089320). {ECO:0000269|PubMed:25075772, ECO:0000269|PubMed:27013146, ECO:0000269|PubMed:27089320, ECO:0000269|PubMed:8836175}.
uniprot
proteins
mass_dalton
17196
uniprot
proteins
mutagenesis
MUTAGEN 24; /note="W->A: Moderately impairs bactericidal activity, bacterial agglutination activity and binding to bacterial lipopolysaccharide (LPS)."; /evidence="ECO:0000269|PubMed:27089320"; MUTAGEN 36; /note="I->A: Strongly impairs bactericidal activity, bacterial agglutination activity and binding to bacterial lipopolysaccharide (LPS)."; /evidence="ECO:0000269|PubMed:27089320"; MUTAGEN 38; /note="H->A: Significantly reduced activity towards dinucleotides UpA and CpA. Slightly reduced activity towards polymeric substrates poly(U) and poly(U):poly(A). No effect on bactericidal activity. Significantly reduced activity towards poly(U) and poly(U):poly(A); when associated with R-59."; /evidence="ECO:0000269|PubMed:27013146, ECO:0000269|PubMed:27089320"; MUTAGEN 59; /note="H->R: No significant effect on activity towards dinucleotides UpA and CpA. Reduced activity towards polymeric substrates poly(U) and poly(U):poly(A). Significantly reduced activity towards poly(U) and poly(U):poly(A); when associated with A-38."; /evidence="ECO:0000269|PubMed:27013146
uniprot
proteins
protein_family
Pancreatic ribonuclease family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
25075772
uniprot
proteins
pubmed
27013146
uniprot
proteins
pubmed
27089320
uniprot
proteins
pubmed
8836175
uniprot
proteins
sequence_length
150
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25075772}. Lysosome {ECO:0000305|PubMed:25075772}. Cytoplasmic granule {ECO:0000269|PubMed:25075772}.
uniprot
proteins