Mta1
entrez
64520
canonical
uniprot
Q62599
canonical
ensembl
ENSRNOG00000004711
resolver
ensp
ENSRNOP00000006521
resolver
ensp
ENSRNOP00000084698
resolver
enst
ENSRNOT00000006521
resolver
genesymbol
Mta1
resolver
genesymbol_syn
Zg29
resolver
uniprot
A0A140TA98
resolver
uniprot
Q9Z0N8
resolver
uniprot_entry
A0A140TA98_RAT
resolver
uniprot_entry
MTA1_RAT
resolver
uniprot_sec
Q9Z0N8
resolver
amino_acid_sequence
MAANMYRVGDYVYFENSSSNPYLIRRIEELNKTANGNVEAKVVCFYRRRDISSSLIALADKHATLSVCYRAGPGADTGEEGEVEEEVENPEMVDLPEKLKHQLRHRELFLSRQLESLPATHIRGKCSVTLLNETESLKSYLEREDFFFYSLVYDPQQKTLLADKGEIRVGNRYQADITDLLKDGEEDGRDQSKLETKVWEAHNPLVDKQIDQFLVVARSVGTFARALDCSSSVRQPSLHMSAAAASRDITLFHAMDTLHKNIYDISKAISALVPQGGPVLCRDEMEEWSASEANLFEEALEKYGKDFTDIQQDFLPWKSLTSIIEYYYMWKTTDRYVQQKRLKAAEAESKLKQVYIPNYNKPNPNQISVNSVKASVVNGTGTPGQSPGAGRACESCYTTQSYQWYSWGPPNMQCRLCASCWTYWKKYGGLKMPTRLDGERPGPNRNNMSPHGIPARSSGSPKFAMKTRQAFYLHTTKLTRIARRLCREILRPWHAARHPYMPINSAAIKAECTARLPEASQSPLVLKQVVRKPLEAVLRYLETHPRPPKPDPVKSSSSVLSSLTPAKSAPVINNGSPTILGKRSYEQHNGVDGLANHGQTRHMGPSRNLLLNGKSYPTKVRLIRGGSLPPVKRRRMNWIDAPDDVFYMATEETRKIRKLLSSSETKRAARRPYKPIALRQSQALPLRPPPPAPVNDEPIVIED
uniprot
proteins
function
FUNCTION: Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity). In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (By similarity). In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (By similarity). Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex (By similarity). Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (By similarity). Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (By similarity). Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (By similarity). Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (By similarity). Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (By similarity). Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity). With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity). {ECO:0000250|UniProtKB:Q13330, ECO:0000250|UniProtKB:Q8K4B0}.
uniprot
proteins
mass_dalton
79412
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by CSNK1G2/CK1 triggered by estrogen enhances corepression of estrogen receptor (ER). {ECO:0000250}.; PTM: Acetylation is essential for its transcriptional coactivator activity. {ECO:0000250}.; PTM: Sumoylation positively regulates its transcriptional corepressor activity but does not affect the protein stability. Sumoylated preferentially by SUMO2 or SUMO3 than SUMO1. Sumoylation is enhanced by PIAS1/3/4 and preferentially sumoylated by SUMO2 in the presence of PIAS1/3/4. Desumoylated by SENP1 (By similarity). {ECO:0000250}.; PTM: Ubiquitinated by COP1, which leads to proteasomal degradation. {ECO:0000250}.
uniprot
proteins
protein_family
Metastasis-associated protein family
uniprot
proteins
pubmed
10393810
uniprot
proteins
pubmed
10933808
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7607577
uniprot
proteins
pubmed
8083195
uniprot
proteins
sequence_length
703
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:10393810}. Nucleus envelope {ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-ProRule:PRU00624}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Associated with microtubules. Localization at the nuclear envelope is TPR-dependent (By similarity). {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Rough endoplasmic reticulum {ECO:0000269|PubMed:10393810}. Golgi apparatus {ECO:0000269|PubMed:10393810}. Zymogen granule {ECO:0000269|PubMed:10393810}.
uniprot
proteins