Cdk19
entrez
78334
canonical
uniprot
Q8BWD8
canonical
ensembl
ENSMUSG00000038481
resolver
ensp
ENSMUSP00000040936
resolver
ensp
ENSMUSP00000093414
resolver
enst
ENSMUST00000044672
resolver
enst
ENSMUST00000095743
resolver
genesymbol
Cdk19
resolver
genesymbol_syn
Cdc2l6
resolver
genesymbol_syn
Kiaa1028
resolver
uniprot
B7ZMT1
resolver
uniprot
G5E8L1
resolver
uniprot
Q80TM1
resolver
uniprot
Q8BKC7
resolver
uniprot_entry
B7ZMT1_MOUSE
resolver
uniprot_entry
CDK19_MOUSE
resolver
uniprot_entry
G5E8L1_MOUSE
resolver
uniprot_entry
Q8BKC7_MOUSE
resolver
uniprot_sec
Q80TM1
resolver
amino_acid_sequence
MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDEPEEKGDKNQPQQQNPHQQPAAPAQQTAAPPQAPPPQQSSAQTNGTAGGATAGGGGAGAGLQHSQDPGLNQVPPNKKPRIGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSQQSTQYHSSHQTHRY
uniprot
proteins
ec_number
2.7.11.22
uniprot
proteins
function
FUNCTION: Component of the Mediator complex, a transcriptional coactivator required for regulated expression of nearly all RNA polymerase II-dependent genes. Acts as a molecular bridge between gene-specific regulatory proteins and the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters through direct interactions with transcriptional regulators and serves as a scaffold for assembly of the pre-initiation complex with RNA polymerase II and general transcription factors. Contributes to phosphorylation of transcription factors and other substrates, including RNA polymerase II and the Notch1 intracellular domain (ICN1), thereby modulating gene expression programs (By similarity). Plays a role together with CDK8 in normal macrophage differentiation (PubMed:41123539). {ECO:0000250|UniProtKB:Q9BWU1, ECO:0000269|PubMed:41123539}.
uniprot
proteins
mass_dalton
56570
uniprot
proteins
protein_family
CDC2/CDKX subfamily
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
41123539
uniprot
proteins
sequence_length
501
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BWU1}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9BWU1}. Nucleus {ECO:0000250|UniProtKB:Q9BWU1}.
uniprot
proteins