Nkx2-1
entrez
21869
canonical
uniprot
P50220
canonical
ensembl
ENSMUSG00000001496
resolver
ensp
ENSMUSP00000001536
resolver
ensp
ENSMUSP00000136103
resolver
enst
ENSMUST00000001536
resolver
enst
ENSMUST00000178477
resolver
genesymbol
Nkx2-1
resolver
genesymbol_syn
Nkx-2.1
resolver
genesymbol_syn
Titf1
resolver
genesymbol_syn
Ttf1
resolver
uniprot
Q6PFE0
resolver
uniprot_entry
NKX21_MOUSE
resolver
uniprot_entry
Q6PFE0_MOUSE
resolver
amino_acid_sequence
MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAASLQSHAQQQAQQQAQAAQAAAAAISVGSGGAGLGAHPGHQPGSAGQSPDLAHHAASPAGLQGQVSSLSHLNSSGSDYGAMSCSTLLYGRTW
uniprot
proteins
function
FUNCTION: Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation (PubMed:22955271). Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (PubMed:22356123). {ECO:0000250|UniProtKB:P23441, ECO:0000269|PubMed:22356123, ECO:0000269|PubMed:22955271}.
uniprot
proteins
mass_dalton
38570
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine residues by STK3/MST2. {ECO:0000250}.
uniprot
proteins
protein_family
NK-2 homeobox family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22356123
uniprot
proteins
pubmed
22955271
uniprot
proteins
pubmed
7711079
uniprot
proteins
sequence_length
372
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22955271}.
uniprot
proteins