Smc6
entrez
67241
canonical
uniprot
Q924W5
canonical
ensembl
ENSMUSG00000020608
resolver
ensp
ENSMUSP00000020931
resolver
ensp
ENSMUSP00000151976
resolver
ensp
ENSMUSP00000211441
resolver
ensp
ENSMUSP00000331020
resolver
genesymbol
Smc6
resolver
genesymbol_syn
Kiaa4103
resolver
genesymbol_syn
Smc6l1
resolver
uniprot
Q3UFI5
resolver
uniprot
Q3UX54
resolver
uniprot
Q499E1
resolver
uniprot
Q5DTN2
resolver
uniprot
Q8BFU9
resolver
uniprot
Q8R0T4
resolver
uniprot
Q9CSK7
resolver
uniprot
Q9CV94
resolver
uniprot
Q9CZZ5
resolver
uniprot
Q9D169
resolver
uniprot
Q9D6B2
resolver
uniprot_entry
SMC6_MOUSE
resolver
uniprot_sec
Q3UFI5
resolver
uniprot_sec
Q3UX54
resolver
uniprot_sec
Q499E1
resolver
uniprot_sec
Q5DTN2
resolver
uniprot_sec
Q8BFU9
resolver
uniprot_sec
Q8R0T4
resolver
uniprot_sec
Q9CSK7
resolver
uniprot_sec
Q9CV94
resolver
uniprot_sec
Q9CZZ5
resolver
uniprot_sec
Q9D169
resolver
uniprot_sec
Q9D6B2
resolver
amino_acid_sequence
MAKRKEENFCSPENAKRPRQEELEDFDKDGDEDECTISFTNGTSTLTAAEVGIIESIQLRNFMCHSMLGPFKFGSNVNFVVGNNGSGKSAVLTALIVGLGGKAVATNRGSSLKGFVKAGQNSADISITLRNRGDDAFRANVYGDSIVVQQHISVDGSRSYKLKSEKGTVVSTRKEELIAILDHFNIQVDNPVSVLTQEMSKQFLQSKNEGDKYKFFMKATQLEQMKEDYSYIMETKERTKEQINQGEERLTELKRQCLEKEERFQNIAGLSTMKTNLEYLKHEMAWAVVNEIEKQLNAIRDNIKIGEERAAKLDRKMEEQQVRLNDAEKKYKDIQDKLEKISEETNARAPECMALKTDVIARTRAFNDAEVLYNRSLNEYKALKKDGEQLCKRIEELKKSTDQSLEPERLERQKRICWLKEKVKALQDQEHTVNQEAEQFEQAIEKDKQEHGRVRKEDIEVRHALNYNQRQLKELKDSKTDRLKRFGPHVPALLEAIDDAYRRRQFTHKPIGPLGACIHLRDPELALAIESCLKGLLQAYCCHNHADERVLQSLMKKFYPPGTSRPQIIVSEFRDEVYDVRLRAAYHPEFPTVLTALEIDNAVVANSLIDMRSIETVLLIKNNSVARAVMQSQKPPKNCREAFTADGDQVFAGRYYSSESTRPKFLSRDVDSEISDLETEIENKKGHIITLQQRLSALEKDIKRNEELLKRCQLHYKEIKMKIRKNISEIRELENIEEHQSVDIATLEDEAEENKIKMQMVEKNMEQQKENMENLKSLKIEAENKYDTIKLKINQLSELADPLKDELNLADSEVDSQKRGKQHYEDKQKEHLDTLNKKRRELDMKEKELQEKMSQARQICPERIEVKKSASILDKEINRLRQKIQAEHASHGDREEIMKQYQEARETYLDLDNKVRTLRRFIKLLEEIMTHRYKTYQQFRRCLTLRCKLYFDNLLSQRAYCGKMNFDHKNETLSITVQPGEGNKASFNDMRALSGGERSFSTVCFILSLWSIAESPFRCLDEFDVYMDMVNRRIAMDMILKMADSQRFRQFILLTPQSMSSLPSSKLIRILRMSDPERGQTTLPFRPVTQEEDDSAS
uniprot
proteins
function
FUNCTION: Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
127198
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250}.; PTM: Sumoylated by NSMCE2/MMS21. {ECO:0000250}.; PTM: Ubiquitinated. {ECO:0000250}.
uniprot
proteins
protein_family
SMC family
uniprot
proteins
protein_family
SMC6 subfamily
uniprot
proteins
pubmed
11408570
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1097
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11408570}. Nucleus speckle {ECO:0000250|UniProtKB:Q96SB8}. Chromosome {ECO:0000269|PubMed:11408570}. Nucleus, PML body {ECO:0000250|UniProtKB:Q96SB8}. Chromosome, telomere {ECO:0000250|UniProtKB:Q96SB8}. Note=Localizes to PML nuclear bodies in ALT cell lines. Associates with chromatin. Accumulates with RAD18 and the SLF1-SLF2 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner. Localizes in interchromatin granule clusters (By similarity). Colocalizes with SMC5 on the X-Y chromosome pair within the sex vesicle during late pachytene/diplotene (PubMed:11408570). {ECO:0000250|UniProtKB:Q96SB8, ECO:0000269|PubMed:11408570}.
uniprot
proteins