PTGES3
entrez
10728
canonical
uniprot
Q15185
canonical
ensembl
ENSG00000110958
resolver
ensp
ENSP00000262033
resolver
ensp
ENSP00000402385
resolver
ensp
ENSP00000405299
resolver
ensp
ENSP00000414892
resolver
ensp
ENSP00000482075
resolver
ensp
ENSP00000548369
resolver
ensp
ENSP00000659171
resolver
enst
ENST00000614328
resolver
genesymbol
PTGES3
resolver
genesymbol_syn
P23
resolver
genesymbol_syn
TEBP
resolver
hgnc
HGNC:16049
resolver
uniprot
A0A087WYT3
resolver
uniprot
A8K7D0
resolver
uniprot
B3KUY2
resolver
uniprot
B4DHP2
resolver
uniprot
B4DP11
resolver
uniprot
B4DP21
resolver
uniprot
Q8WU70
resolver
uniprot_entry
A0A087WYT3_HUMAN
resolver
uniprot_entry
B3KUY2_HUMAN
resolver
uniprot_entry
TEBP_HUMAN
resolver
uniprot_sec
A8K7D0
resolver
uniprot_sec
B4DHP2
resolver
uniprot_sec
B4DP11
resolver
uniprot_sec
B4DP21
resolver
uniprot_sec
Q8WU70
resolver
amino_acid_sequence
MQPASAKWYDRRDYVFIEFCVEDSKDVNVNFEKSKLTFSCLGGSDNFKHLNEIDLFHCIDPNDSKHKRTDRSILCCLRKGESGQSWPRLTKERAKLNWLSVDFNNWKDWEDDSDEDMSNFDRFSEMMNNMGGDEDVDLPEVDGADDDSQDSDDEKMPDLE
uniprot
proteins
ec_number
5.3.99.3
uniprot
proteins
function
FUNCTION: Cytosolic prostaglandin synthase that catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) (PubMed:10922363). Molecular chaperone that localizes to genomic response elements in a hormone-dependent manner and disrupts receptor-mediated transcriptional activation, by promoting disassembly of transcriptional regulatory complexes (PubMed:11274138, PubMed:12077419). Facilitates HIF alpha proteins hydroxylation via interaction with EGLN1/PHD2, leading to recruit EGLN1/PHD2 to the HSP90 pathway (PubMed:24711448). {ECO:0000269|PubMed:10922363, ECO:0000269|PubMed:11274138, ECO:0000269|PubMed:12077419, ECO:0000269|PubMed:24711448}.
uniprot
proteins
mass_dalton
18697
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; prostaglandin biosynthesis. {ECO:0000269|PubMed:10922363}.
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved by caspase-7 (CASP7) in response to apoptosis, leading to its inactivation. {ECO:0000269|PubMed:22451931, ECO:0000269|PubMed:28863261}.
uniprot
proteins
protein_family
P23/wos2 family
uniprot
proteins
pubmed
10811660
uniprot
proteins
pubmed
10922363
uniprot
proteins
pubmed
11274138
uniprot
proteins
pubmed
12077419
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
16807684
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17487921
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22451931
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24711448
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27353360
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28863261
uniprot
proteins
pubmed
29127155
uniprot
proteins
pubmed
8114727
uniprot
proteins
sequence_length
160
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q3ZBF7}.
uniprot
proteins