Gas1
entrez
14451
canonical
uniprot
Q01721
canonical
ensembl
ENSMUSG00000052957
resolver
ensp
ENSMUSP00000064555
resolver
ensp
ENSMUSP00000153311
resolver
enst
ENSMUST00000065086
resolver
enst
ENSMUST00000223933
resolver
genesymbol
Gas1
resolver
genesymbol_syn
Gas-1
resolver
uniprot
A0A286YD87
resolver
uniprot_entry
A0A286YD87_MOUSE
resolver
uniprot_entry
GAS1_MOUSE
resolver
amino_acid_sequence
MLAALLGGAGARTGTLPGALLCLMALLQLLCSAPRGSGLAHGRRLICWQALLQCQGEPDCSYAYSQYAEACAPVLAQRGGADAPGPAGAFPASAASSPRWRCPSHCISALIQLNHTRRGPALEDCDCAQDEHCRSTKRAIEPCLPRTSSVGPGAGAGSVMGCTEARRRCDRDSRCNLALSRYLAYCGKLFNGLRCTDECRAVIEDMLAVPKAALLNDCVCDGLERPICESVKENMARLCFGPDASNGPGSSGSDGGLDDYYDEEYDDEQRAGAAGGEQPLDDDDGLARPGGGAAAAGGRGDLPHGPGRRSSSSGSGGHWANRSAWTPFACLLLLLLLLLGSHL
uniprot
proteins
function
FUNCTION: Coreceptor required for sonic hedgehog (SHH) handoff to its receptor: binds to the dually lipid-modified Sonic hedgehog protein N-product (ShhN) downstream of the CDON-BOC heterodimer and directly transfers ShhN to its patched receptor (PTCH1 or PTCH2), followed by activation of the smoothened signaling pathway (PubMed:17504940, PubMed:21664576, PubMed:33038332). Specifically recognizes and binds palmitate and cholesterol moieties in dually lipid-modified ShhN (PubMed:33038332). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (PubMed:34799735). Acts as a growth arrest protein involved in growth suppression by blocking entry to S phase (PubMed:1505026). {ECO:0000269|PubMed:1505026, ECO:0000269|PubMed:17504940, ECO:0000269|PubMed:21664576, ECO:0000269|PubMed:33038332, ECO:0000269|PubMed:34799735}.
uniprot
proteins
mass_dalton
35694
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:21664576}.
uniprot
proteins
pubmed
10996315
uniprot
proteins
pubmed
11456441
uniprot
proteins
pubmed
11572986
uniprot
proteins
pubmed
12399319
uniprot
proteins
pubmed
1505026
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17504940
uniprot
proteins
pubmed
21664576
uniprot
proteins
pubmed
33038332
uniprot
proteins
pubmed
34799735
uniprot
proteins
sequence_length
343
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21664576}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:21664576}; Extracellular side {ECO:0000269|PubMed:21664576}.
uniprot
proteins