Slco4a1
entrez
108115
canonical
uniprot
Q8K078
canonical
ensembl
ENSMUSG00000038963
resolver
ensp
ENSMUSP00000045023
resolver
ensp
ENSMUSP00000046502
resolver
genesymbol
Slco4a1
resolver
genesymbol_syn
Oatp4a1
resolver
genesymbol_syn
Oatpe
resolver
genesymbol_syn
Slc21a12
resolver
uniprot
Q8BZT4
resolver
uniprot_entry
SO4A1_MOUSE
resolver
uniprot_sec
Q8BZT4
resolver
amino_acid_sequence
MPQHAMGDTHFLSLPKHLFTSTSSATDSGCDTPPSSRASPASLRSAHGTLGSSSQPLFEPQAEKRSSQTAREVQYVSSGPQNSLCGWQAFTPKCLQVFNTPKGFLFFLCAASFLQGMTVNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGVLVLGIGSLVFALPHFTAGRYEVEMDEGLGTGTCLTNQSHVECKDSASGLSNYRLIFMLGQLLHGVGATPLYTLGVTYLDENVKSSYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYTEVGQRTELTTDSPLWVGAWWIGFLGTGIAAFLIAIPILGYPRQLPGSQRYVVMRAAETQQLKDHSRGAVSNPAFGKTVRDLPLSIWLLLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFCLFCTLTSLLAFFVFLMHCPNVHMAGVTTGYVGSLLPKGQLDLKAACNAIYCCQPKHYSPLCGSDGTMYYSPCYAGCPADAETDLGGQKVYRGCSCILEKASSGWGNATAGKCASTCQSKPFLLVLVFVVIIFTFLSSIPALTATLRCVSDRQRSFALGIQWIVVRTLGSIPGPIAFGWVIDKACLLWQDQCGHQGSCFVYENEAMSRYMLIAGLTFKVLGFLFFVAAYFLYKSPSVSSDGLEASLPSQSSASDSPTEQLQSNV
uniprot
proteins
function
FUNCTION: Organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormones 3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4) and 3,3',5'-triiodo-L-thyronine (rT3), conjugated steroids such as estrone 3-sulfate and estradiol 17-beta glucuronide, bile acids such as taurocholate and prostanoids such as prostaglandin E2, likely operating in a tissue-specific manner (By similarity). May be involved in uptake of metabolites from the circulation into organs such as kidney, liver or placenta. Possibly drives the selective transport of thyroid hormones and estrogens coupled to an outward glutamate gradient across the microvillous membrane of the placenta (By similarity). The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable). {ECO:0000250|UniProtKB:Q96BD0, ECO:0000305}.
uniprot
proteins
mass_dalton
77669
uniprot
proteins
protein_family
Organo anion transporter (TC 2.A.60) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
sequence_length
723
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q96BD0}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 103..123; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 143..163; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 170..194; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 225..255; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 275..295; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 310..334; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 381..402; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 423..446; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 451..473; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 583..605; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 615..640; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 674..691; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins