Rhcg
entrez
293048
canonical
uniprot
Q7TNN9
canonical
ensembl
ENSRNOG00000015526
resolver
ensp
ENSRNOP00000021109
resolver
enst
ENSRNOT00000021109
resolver
genesymbol
Rhcg
resolver
uniprot
F1M794
resolver
uniprot_entry
F1M794_RAT
resolver
uniprot_entry
RHCG_RAT
resolver
amino_acid_sequence
MAWNTNLRGRLPITCLILQVTMVVLFGVFVRYDIQADAHWWLEKKRKNISSDVENEFYYRYPSFEDVHAMVFVGFGFLMTYLQRYGFSAVGFNFLLAAFGIQWALLMQGWFHFFEEGHILLSVENLIQADFCVASTCVAFGAVLGKISPMQLLIMTFFQVTLFTVNEFILLNLIEAKDAGGSMTIHTFGAYFGLTVTWILYRKNLEQSKQRQSSVYHSDLFAMIGTLFLWIYWPSFNSASSFHGDTQHRAALNTYLSLAASVLTTVAVSSVIHKKGKLDMVHIQNATLAGGVGVGTAAEMMLTPYGALIVGFFCGILSTLGFAYLSPFLESRLRIQDTCGIHNLHGIPGIIGGIVGAVTAAYSSPDVYGEPGIVHSFGFGGYKADWTKRMQGRSQIFGLLLSLAMALVGGIIVGFILKLPFWGQASDENCFEDAIYWEVPEEVNTVYIPEDLAHKHSTSLVPAIPLVLSTPSASIVPPVPPTPPASLATVTSSSLVH
uniprot
proteins
function
FUNCTION: Ammonium transporter involved in the maintenance of acid-base homeostasis. Transports ammonium and its related derivative methylammonium across the plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism. Postulated to primarily mediate an electroneutral bidirectional transport of NH3 ammonia species according to a mechanism that implies interaction of an NH4(+) ion with acidic residues of the pore entry followed by dissociation of NH4(+) into NH3 and H(+). As a result NH3 transits through the central pore and is protonated on the extracellular side reforming NH4(+) (By similarity). May act as a CO2 channel providing for renal acid secretion (By similarity). {ECO:0000250|UniProtKB:Q9UBD6}.
uniprot
proteins
mass_dalton
54731
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250}.
uniprot
proteins
protein_family
Ammonium transporter (TC 2.A.49) family
uniprot
proteins
protein_family
Rh subfamily
uniprot
proteins
pubmed
12138130
uniprot
proteins
pubmed
12595489
uniprot
proteins
pubmed
16227429
uniprot
proteins
pubmed
16434569
uniprot
proteins
sequence_length
497
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9UBD6}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:12138130, ECO:0000269|PubMed:12595489, ECO:0000269|PubMed:16434569}; Multi-pass membrane protein {ECO:0000255}. Note=Also detected at the basolateral membrane and in subapical vesicles. Chronic acidosis induces relocalization to the apical cell membrane.
uniprot
proteins
transmembrane_region
TRANSMEM 10..30; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 62..82; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 94..114; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 126..145; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 152..174; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 180..200; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 220..240; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 252..272; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 283..303; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 305..325; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 341..361; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 396..416; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins