Tomm22
entrez
300075
canonical
uniprot
Q75Q41
canonical
ensembl
ENSRNOG00000014058
resolver
ensp
ENSRNOP00000080542
resolver
genesymbol
Tomm22
resolver
genesymbol_syn
Tom22
resolver
uniprot_entry
TOM22_RAT
resolver
amino_acid_sequence
MAAAVAAAGAGEPLSPEELVPKAEAEKAEEDLEEDDDDELDETLSERLWGLTEMFPERVRSAAGATFDLSLFVAQKMYRFSRAALWIGTTSFMILVLPVVFETEKLQMEQQQQLQQRQILLGPNTGLSGGMPGALPPLPGKI
uniprot
proteins
function
FUNCTION: Central receptor component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (By similarity). Together with the peripheral receptor TOMM20, functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore (By similarity). The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases (PubMed:19401463). {ECO:0000250|UniProtKB:Q9NS69, ECO:0000269|PubMed:19401463}.
uniprot
proteins
mass_dalton
15491
uniprot
proteins
mutagenesis
MUTAGEN 42; /note="E->Q: Inhibits localization to the mitochondrion outer membrane."; /evidence="ECO:0000269|PubMed:15923182"; MUTAGEN 46; /note="E->P: Inhibits localization to the mitochondrion outer membrane."; /evidence="ECO:0000269|PubMed:15923182"; MUTAGEN 49; /note="W->P: Inhibits localization to the mitochondrion outer membrane."; /evidence="ECO:0000269|PubMed:15923182"; MUTAGEN 98; /note="P->A: Inhibits localization to the mitochondrion outer membrane."; /evidence="ECO:0000269|PubMed:15923182
uniprot
proteins
protein_family
Tom22 family
uniprot
proteins
pubmed
14985332
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15923182
uniprot
proteins
pubmed
19401463
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
142
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9NS69}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9NS69}.
uniprot
proteins
transmembrane_region
TRANSMEM 83..103; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NS69
uniprot
proteins