Egr2
entrez
13654
canonical
uniprot
P08152
canonical
ensembl
ENSMUSG00000037868
resolver
ensp
ENSMUSP00000041053
resolver
ensp
ENSMUSP00000101078
resolver
genesymbol
Egr2
resolver
genesymbol_syn
Egr-2
resolver
genesymbol_syn
Krox-20
resolver
genesymbol_syn
Zfp-25
resolver
uniprot
Q3U207
resolver
uniprot_entry
EGR2_MOUSE
resolver
uniprot_entry
Q3U207_MOUSE
resolver
amino_acid_sequence
MMTAKAVDKIPVTLSGFMHQLPDSLYPVEDLAASSVTIFPNGELGGPFDQMNGVAGDGMINIDMTGEKRPLDLPYPSSFAPISAPRNQTFTYMGKFSIDPQYPGASCYPEGIINIVSAGILQGVTPPASTTASSSVTSASPNPLATGPLGVCTMSQTQPELDHLYSPPPPPPPYSGCTGDLYQDPSAFLSPPSTTSTSSLAYQPPPSYPSPKPAMDPGLIPMIPDYPGFFPSPCQRDPHGAAGPDRKPFPCPLDSLRVPPPLTPLSTIRNFTLGGPGAGVTGPGASGGGEGPRLPGSGSAAVTATPYNPHHLPLRPILRPRKYPNRPSKTPVHERPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSDERKRHTKIHLRQKERKSSAPSAPPSAQSSASGPGGSQAGGSLCGNSAIGGPLASCTSRTRTP
uniprot
proteins
ec_number
2.3.2.-
uniprot
proteins
function
FUNCTION: Sequence-specific DNA-binding transcription factor (PubMed:11823429, PubMed:1674431, PubMed:1969796, PubMed:31852952). Plays a role in hindbrain segmentation by regulating the expression of a subset of homeobox containing genes and in Schwann cell myelination by regulating the expression of genes involved in the formation and maintenance of myelin (PubMed:11823429, PubMed:1674431, PubMed:1969796, PubMed:31852952, PubMed:8093858). Binds to two EGR2-consensus sites EGR2A (5'-CTGTAGGAG-3') and EGR2B (5'-ATGTAGGTG-3') in the HOXB3 enhancer and promotes HOXB3 transcriptional activation (PubMed:11823429). Binds to specific DNA sites located in the promoter region of HOXA4, HOXB2 and ERBB2 (PubMed:17938205, PubMed:1969796, PubMed:8093858). Regulates hindbrain segmentation by controlling the expression of Hox genes, such as HOXA4, HOXB3 and HOXB2, and thereby specifying odd and even rhombomeres (PubMed:11823429, PubMed:1674431). Promotes the expression of HOXB3 in the rhombomere r5 and of HOXB3 in r3 and r5 in the hindbrain (PubMed:11823429, PubMed:8093858). Regulates myelination in the peripheral nervous system after birth, possibly by regulating the expression of myelin proteins, such as MPZ, and by promoting the differentiation of Schwann cells (PubMed:10068633, PubMed:7935840). Involved in the development of the jaw openener musculature, probably by playing a role in its innervation through trigeminal motor neurons (PubMed:11509834). May play a role in adipogenesis, possibly by regulating the expression of CEBPB (PubMed:16054051). {ECO:0000269|PubMed:10068633, ECO:0000269|PubMed:11509834, ECO:0000269|PubMed:11823429, ECO:0000269|PubMed:16054051, ECO:0000269|PubMed:1674431, ECO:0000269|PubMed:17938205, ECO:0000269|PubMed:1969796, ECO:0000269|PubMed:31852952, ECO:0000269|PubMed:7935840, ECO:0000269|PubMed:8093858}.; FUNCTION: E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity. {ECO:0000250|UniProtKB:P11161}.
uniprot
proteins
mass_dalton
49819
uniprot
proteins
mutagenesis
MUTAGEN 174; /note="Y->F: Abolishes interaction with WWP2; if associated with F-208."; /evidence="ECO:0000269|PubMed:19651900"; MUTAGEN 208; /note="Y->F: Abolishes interaction with WWP2; if associated with F-174."; /evidence="ECO:0000269|PubMed:19651900"; MUTAGEN 247; /note="K->R: Abolishes acetylation."; /evidence="ECO:0000269|PubMed:28576496"; MUTAGEN 377; /note="S->A: Inhibits interaction with SFN."; /evidence="ECO:0000269|PubMed:17938205"; MUTAGEN 408; /note="D->G: Reduces transcriptional regulatory activity."; /evidence="ECO:0000269|PubMed:31852952
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein sumoylation.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by WWP2 leading to proteasomal degradation. {ECO:0000269|PubMed:19651900}.; PTM: Acetylated at Lys-247. May be deacetylated by HDAC6, HDAC10 or SIRT1. {ECO:0000269|PubMed:28576496}.
uniprot
proteins
protein_family
EGR C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
10068633
uniprot
proteins
pubmed
11509834
uniprot
proteins
pubmed
11823429
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1598206
uniprot
proteins
pubmed
16054051
uniprot
proteins
pubmed
1674431
uniprot
proteins
pubmed
17938205
uniprot
proteins
pubmed
19651900
uniprot
proteins
pubmed
1969796
uniprot
proteins
pubmed
2452975
uniprot
proteins
pubmed
2496302
uniprot
proteins
pubmed
28576496
uniprot
proteins
pubmed
3129290
uniprot
proteins
pubmed
31852952
uniprot
proteins
pubmed
32736174
uniprot
proteins
pubmed
7935840
uniprot
proteins
pubmed
8093858
uniprot
proteins
sequence_length
470
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17938205}.
uniprot
proteins