Tnp2
entrez
21959
canonical
uniprot
P11378
canonical
ensembl
ENSMUSG00000043050
resolver
ensp
ENSMUSP00000053078
resolver
enst
ENSMUST00000051297
resolver
genesymbol
Tnp2
resolver
uniprot
Q91XK4
resolver
uniprot_entry
STP2_MOUSE
resolver
uniprot_sec
Q91XK4
resolver
amino_acid_sequence
MDTKMQSLPTTHPHPHSSSRPQSHTSNQCNQCTCSHHCRSCSQAGHAGSSSSPSPGPPMKHPKPSVHSRHSPARPSHRGSCPKNRKTFEGKVSKRKAVRRRKRTHRAKRRSSGRRYK
uniprot
proteins
function
FUNCTION: Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals (PubMed:15083521, PubMed:15163613, PubMed:15189834, PubMed:28366643). In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction (PubMed:28366643). The histone H2AB1-H2BC1/TH2B dimer is required for loading of TNP2 onto chromatin (PubMed:28366643). {ECO:0000269|PubMed:15083521, ECO:0000269|PubMed:15163613, ECO:0000269|PubMed:15189834, ECO:0000269|PubMed:28366643}.
uniprot
proteins
mass_dalton
13117
uniprot
proteins
protein_family
Nuclear transition protein 2 family
uniprot
proteins
pubmed
15083521
uniprot
proteins
pubmed
15163613
uniprot
proteins
pubmed
15189834
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
2249785
uniprot
proteins
pubmed
28366643
uniprot
proteins
pubmed
32726616
uniprot
proteins
pubmed
3693351
uniprot
proteins
pubmed
8720108
uniprot
proteins
sequence_length
117
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15163613}. Chromosome {ECO:0000269|PubMed:28366643}. Note=Loaded onto the nucleosomes of condensing spermatids (PubMed:28366643). Inclusion of the H2AB1-H2BC1/TH2B dimer into chromatin opens the nucleosomes, releasing the nucleosomal DNA ends and allowing the invasion of nucleosomes by transition protein TNP2 (PubMed:28366643). Nuclear import is mediated by IPO4. Nucleolar localization requires the protein to be phosphorylated (By similarity). {ECO:0000250|UniProtKB:P11101, ECO:0000269|PubMed:28366643}.
uniprot
proteins