IRAG1
entrez
10335
canonical
uniprot
Q9Y6F6
canonical
ensembl
ENSG00000072952
resolver
ensp
ENSP00000412130
resolver
ensp
ENSP00000432436
resolver
ensp
ENSP00000437784
resolver
ensp
ENSP00000448278
resolver
ensp
ENSP00000453013
resolver
genesymbol
IRAG1
resolver
genesymbol_syn
IRAG
resolver
genesymbol_syn
JAW1L
resolver
genesymbol_syn
MRVI1
resolver
hgnc
HGNC:7237
resolver
uniprot
B7Z3T4
resolver
uniprot
B7Z6I2
resolver
uniprot
B7Z9A3
resolver
uniprot
E9PQY6
resolver
uniprot
F5H6A1
resolver
uniprot
J3KQZ7
resolver
uniprot
Q17S00
resolver
uniprot
Q9UNY1
resolver
uniprot_entry
IRAG1_HUMAN
resolver
uniprot_sec
B7Z3T4
resolver
uniprot_sec
B7Z6I2
resolver
uniprot_sec
B7Z9A3
resolver
uniprot_sec
E9PQY6
resolver
uniprot_sec
F5H6A1
resolver
uniprot_sec
J3KQZ7
resolver
uniprot_sec
Q17S00
resolver
uniprot_sec
Q9UNY1
resolver
amino_acid_sequence
MGMDLTCPFGISPACGAQASWSIFGADAAEVPGTRGHSQQEAAMPHIPEDEEPPGEPQAAQSPAGQGPPAAGVSCSPTPTIVLTGDATSPEGETDKNLANRVHSPHKRLSHRHLKVSTASLTSVDPAGHIIDLVNDQLPDISISEEDKKKNLALLEEAKLVSERFLTRRGRKSRSSPGDSPSAVSPNLSPSASPTSSRSNSLTVPTPPGLDVCSGPPSPLPGAPPQQKGDEADVSSPHPGEPNVPKGLADRKQNDQRKVSQGRLAPRPPPVEKSKEIAIEQKENFDPLQYPETTPKGLAPVTNSSGKMALNSPQPGPVESELGKQLLKTGWEGSPLPRSPTQDAAGVGPPASQGRGPAGEPMGPEAGSKAELPPTVSRPPLLRGLSWDSGPEEPGPRLQKVLAKLPLAEEEKRFAGKAGGKLAKAPGLKDFQIQVQPVRMQKLTKLREEHILMRNQNLVGLKLPDLSEAAEQEKGLPSELSPAIEEEESKSGLDVMPNISDVLLRKLRVHRSLPGSAPPLTEKEVENVFVQLSLAFRNDSYTLESRINQAERERNLTEENTEKELENFKASITSSASLWHHCEHRETYQKLLEDIAVLHRLAARLSSRAEVVGAVRQEKRMSKATEVMMQYVENLKRTYEKDHAELMEFKKLANQNSSRSCGPSEDGVPRTARSMSLTLGKNMPRRRVSVAVVPKFNALNLPGQTPSSSSIPSLPALSESPNGKGSLPVTSALPALLENGKTNGDPDCEASAPALTLSCLEELSQETKARMEEEAYSKGFQEGLKKTKELQDLKEEEEEQKSESPEEPEEVEETEEEEKGPRSSKLEELVHFLQVMYPKLCQHWQVIWMMAAVMLVLTVVLGLYNSYNSCAEQADGPLGRSTCSAAQRDSWWSSGLQHEQPTEQ
uniprot
proteins
function
FUNCTION: Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Also mediates NO-dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation (PubMed:14729908). Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity). {ECO:0000250|UniProtKB:Q9WUX5, ECO:0000269|PubMed:14729908}.
uniprot
proteins
mass_dalton
97957
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PRKG1/cGKI-beta; Ser-386 showed constitutive phosphorylation in platelets whereas Ser-676 is only phosphorylated in presence of cGMP and nitric oxide (NO); Ser-689 is phosphorylated in resting platelets but increases in presence of cGMP and NO. PRKG1 inhibitor prevents phosphorylation of Ser-676 and Ser-689 in response to NO and cGMP. {ECO:0000269|PubMed:16990611}.
uniprot
proteins
pubmed
10321731
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14729908
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16990611
uniprot
proteins
pubmed
17312387
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
904
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Sarcoplasmic reticulum {ECO:0000250}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 844..864; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins