Acadm
entrez
24158
canonical
uniprot
P08503
canonical
ensembl
ENSRNOG00000009845
resolver
ensembl
ENSRNOG00055028387
resolver
ensembl
ENSRNOG00060001604
resolver
ensembl
ENSRNOG00065012684
resolver
ensp
ENSRNOP00000013238
resolver
ensp
ENSRNOP00055040485
resolver
ensp
ENSRNOP00060001585
resolver
ensp
ENSRNOP00065015918
resolver
enst
ENSRNOT00000013238
resolver
enst
ENSRNOT00055049201
resolver
enst
ENSRNOT00060002450
resolver
enst
ENSRNOT00065020681
resolver
genesymbol
Acadm
resolver
uniprot
G3V796
resolver
uniprot_entry
ACADM_RAT
resolver
uniprot_entry
G3V796_RAT
resolver
amino_acid_sequence
MAAALRRGYKVLRSVSHFECRAQHTKPSLKQEPGLGFSFELTEQQKEFQTIARKFAREEIIPVAPDYDKSGEYPFPLIKRAWELGLINTHIPESCGGLGLGTFDACLITEELAYGCTGVQTAIEANSLGQMPVIIAGNDQQKKKYLGRMTEQPMMCAYCVTEPSAGSDVAGIKTKAEKKGDEYVINGQKMWITNGGKANWYFVLTRSNPDPKVPASKAFTGFIVEADTPGIHIGKKELNMGQRCSDTRGITFEDVRVPKENVLIGEGAGFKIAMGAFDRTRPTVAAGAVGLAQRALDEATKYALDRKTFGKLLVEHQGVSFLLAEMAMKVELARLSYQRAAWEVDSGRRNTYFASIAKAFAGDIANQLATDAVQIFGGYGFNTEYPVEKLMRDAKIYQIYEGTAQIQRLIIAREHIEKYKN
uniprot
proteins
ec_number
1.3.8.7
uniprot
proteins
function
FUNCTION: Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation (FAO), breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats (PubMed:3968063). The first step of FAO consists in the proR-proR stereospecific alpha, beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA) (PubMed:3968063). ETF is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase has preference for fatty acyl-CoAs with saturated 6 to 12 carbons long primary chains, making it but can also catalyze longer chains such as C14 and C16 (PubMed:3968063). {ECO:0000250|UniProtKB:P11310, ECO:0000269|PubMed:3968063}.
uniprot
proteins
mass_dalton
46555
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; mitochondrial fatty acid beta-oxidation. {ECO:0000305|PubMed:3968063}.
uniprot
proteins
post_translational_modification
PTM: Acetylated. Could occur at proximity of the cofactor-binding sites and reduce the catalytic activity. Could be deacetylated by SIRT3. {ECO:0000250|UniProtKB:P11310}.
uniprot
proteins
protein_family
Acyl-CoA dehydrogenase family
uniprot
proteins
pubmed
2029527
uniprot
proteins
pubmed
3611054
uniprot
proteins
pubmed
3813556
uniprot
proteins
pubmed
3968063
uniprot
proteins
sequence_length
421
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:3813556, ECO:0000269|PubMed:3968063}.
uniprot
proteins