Chtf8
entrez
364996
canonical
uniprot
P0C6T1
canonical
genesymbol
Chtf8
resolver
genesymbol_syn
Ctf8
resolver
uniprot_entry
CTF8_RAT
resolver
amino_acid_sequence
MVQIVISSTGAEGLAEWVLMELQGEIEARYSTGLAGNLLGDLHYTTEGIPVLIVGHHILYGKIIHLEKPFAVLVKHTPGKQDCDELGRETGTQYLVTALIKNKILFKTRPKPIITNVPKKV
uniprot
proteins
function
FUNCTION: Chromosome cohesion factor involved in sister chromatid cohesion and fidelity of chromosome transmission. Component of one of the cell nuclear antigen loader complexes, CTF18-replication factor C (CTF18-RFC), which consists of CTF18, CTF8, DSCC1, RFC2, RFC3, RFC4 and RFC5. The CTF18-RFC complex binds to single-stranded and primed DNAs and has weak ATPase activity that is stimulated the presence of primed DNA, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA). The CTF18-RFC complex catalyzes the ATP-dependent loading of PCNA onto primed and gapped DNA. It also interacts with and stimulates POLH, which is suggestive of a protein network that coordinates DNA repair, recombination and chromosome cohesion reactions with replication fork progression (By similarity). {ECO:0000250|UniProtKB:P0CG13}.
uniprot
proteins
mass_dalton
13328
uniprot
proteins
protein_family
CTF8 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
121
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P0CG13}. Note=Associates with chromatin during S phase. {ECO:0000250|UniProtKB:P0CG13}.
uniprot
proteins