PSMA4
entrez
5685
canonical
uniprot
P25789
canonical
ensembl
ENSG00000041357
resolver
ensp
ENSP00000044462
resolver
ensp
ENSP00000402118
resolver
ensp
ENSP00000453145
resolver
ensp
ENSP00000453802
resolver
ensp
ENSP00000453829
resolver
ensp
ENSP00000453887
resolver
ensp
ENSP00000529862
resolver
ensp
ENSP00000529867
resolver
ensp
ENSP00000590111
resolver
enst
ENST00000558281
resolver
enst
ENST00000560217
resolver
enst
ENST00000859803
resolver
enst
ENST00000859808
resolver
enst
ENST00000920052
resolver
genesymbol
PSMA4
resolver
genesymbol_syn
HC9
resolver
genesymbol_syn
PSC9
resolver
hgnc
HGNC:9533
resolver
uniprot
D3DW86
resolver
uniprot
H0YLC2
resolver
uniprot
H0YN18
resolver
uniprot
Q53XP2
resolver
uniprot
Q567Q5
resolver
uniprot
Q8TBD1
resolver
uniprot_entry
H0YLC2_HUMAN
resolver
uniprot_entry
H0YN18_HUMAN
resolver
uniprot_entry
PSA4_HUMAN
resolver
uniprot_sec
D3DW86
resolver
uniprot_sec
Q53XP2
resolver
uniprot_sec
Q567Q5
resolver
uniprot_sec
Q8TBD1
resolver
amino_acid_sequence
MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVFFSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYKEGEMTLKSALALAIKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVEQLIKKHEEEEAKAEREKKEKEQKEKDK
uniprot
proteins
function
FUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.
uniprot
proteins
mass_dalton
29484
uniprot
proteins
protein_family
Peptidase T1A family
uniprot
proteins
pubmed
11521686
uniprot
proteins
pubmed
12181345
uniprot
proteins
pubmed
15244466
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
17323924
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
2025653
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23495936
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25599644
uniprot
proteins
pubmed
26133119
uniprot
proteins
pubmed
27176742
uniprot
proteins
pubmed
27342858
uniprot
proteins
pubmed
27428775
uniprot
proteins
pubmed
27493187
uniprot
proteins
pubmed
34711951
uniprot
proteins
pubmed
7811265
uniprot
proteins
pubmed
8610016
uniprot
proteins
pubmed
8692272
uniprot
proteins
sequence_length
261
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Nucleus {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9 (PubMed:34711951). Colocalizes with TRIM5 in the cytoplasmic bodies (By similarity). {ECO:0000250|UniProtKB:Q9R1P0, ECO:0000269|PubMed:34711951}.
uniprot
proteins