Rab14
entrez
68365
canonical
uniprot
Q91V41
canonical
ensembl
ENSMUSG00000026878
resolver
ensp
ENSMUSP00000028238
resolver
ensp
ENSMUSP00000306277
resolver
enst
ENSMUST00000028238
resolver
genesymbol
Rab14
resolver
genesymbol_syn
rab14
resolver
uniprot
Q50HX4
resolver
uniprot_entry
Q50HX4_MOUSE
resolver
uniprot_entry
RAB14_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) including DENND6A and DENND6B which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs) which prevent Rab-GDP dissociation. {ECO:0000250|UniProtKB:P61106}.
uniprot
proteins
amino_acid_sequence
MATAPYNYSYIFKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEVSGQKIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDARNLTNPNTVIILIGNKADLEAQRDVTYEEAKQFAEENGLLFLEASAKTGENVEDAFLEAAKKIYQNIQDGSLDLNAAESGVQHKPSAPQGGRLTSEPQPQREGCGC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB14 is involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development (By similarity). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (PubMed:21238925). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion. Mediates endosomal tethering and fusion through the interaction with RUFY1 and RAB4B (By similarity). Interaction with RAB11FIP1 may function in the process of neurite formation (By similarity). {ECO:0000250|UniProtKB:P61106, ECO:0000250|UniProtKB:P61107, ECO:0000269|PubMed:21238925}.
uniprot
proteins
mass_dalton
23897
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21238925
uniprot
proteins
sequence_length
215
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Recycling endosome {ECO:0000250|UniProtKB:P61106}. Early endosome membrane {ECO:0000250|UniProtKB:P61106}; Lipid-anchor {ECO:0000250|UniProtKB:P61106}; Cytoplasmic side {ECO:0000250|UniProtKB:P61106}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P61106}; Lipid-anchor {ECO:0000250|UniProtKB:P61106}; Cytoplasmic side {ECO:0000250|UniProtKB:P61106}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P61106}; Lipid-anchor {ECO:0000250|UniProtKB:P61106}; Cytoplasmic side {ECO:0000250|UniProtKB:P61106}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:P61106}. Note=Recruited to recycling endosomes by DENND6A. {ECO:0000250|UniProtKB:P61106}.
uniprot
proteins