Pxylp1
entrez
235534
canonical
uniprot
Q8BHA9
canonical
ensembl
ENSMUSG00000043587
resolver
ensp
ENSMUSP00000077571
resolver
ensp
ENSMUSP00000108574
resolver
ensp
ENSMUSP00000113210
resolver
ensp
ENSMUSP00000113489
resolver
ensp
ENSMUSP00000303180
resolver
ensp
ENSMUSP00000303182
resolver
ensp
ENSMUSP00000303196
resolver
enst
ENSMUST00000078478
resolver
enst
ENSMUST00000112951
resolver
enst
ENSMUST00000119141
resolver
enst
ENSMUST00000120101
resolver
genesymbol
Pxylp1
resolver
genesymbol_syn
Acpl2
resolver
uniprot
Q8BZ12
resolver
uniprot_entry
PXYP1_MOUSE
resolver
uniprot_sec
Q8BZ12
resolver
amino_acid_sequence
MLHRNRFLVLLALAGLLAFLSLSLQFFHLIPVSATKNGGSSKSRKRIMPDPVTEPPTVDPVYEALLYCNIPSVAEHSMEGHAPHHYKLVSVHVFIRHGDRYPLYAIPKTKRPEIDCTLVASRKPYHPKLEAFISHMLKGSGASFESPLNSLPLYPNHPLCETGELTQTGVVQHLLNGQLLRDIYLRKHKLLPNNWSSDQLYLESTGKSRTLQSGLALLYGFLPEFDWKKVYFKHQPSALFCSGSCYCPLRNQYLEKEQRRQYLLRLKNSDLERTYGEMAKIVDIPTKQLRAANPIDSMLCHFCHNVSFPCSRSGCLGMEHFKVIKTHQIEDERERHEKLLYFGYSLLGAHPILNQTVNRMQRAASGWRDELFTLYSAHDVTLSPILSALGLLEARFPRFAARLVFELWQDRQKPSEHSVRILYNGADVTFHTSFCHDFHKRSPKPMCPLENLVRFVKRDMFVALDGSSTNYYDACHGEGA
uniprot
proteins
ec_number
3.1.3.-
uniprot
proteins
function
FUNCTION: Responsible for the 2-O-dephosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature glycosaminoglycan (GAG) chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-dephosphorylation during completion of linkage region formation is a prerequisite for the initiation and efficient elongation of the repeating disaccharide region of GAG chains. {ECO:0000250|UniProtKB:Q8TE99}.
uniprot
proteins
mass_dalton
54937
uniprot
proteins
protein_family
Histidine acid phosphatase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
480
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8TE99}; Single-pass type II membrane protein {ECO:0000255}. Note=Colocalizes to Golgi apparatus in a B3GAT3-dependent manner. {ECO:0000250|UniProtKB:Q8TE99}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..27; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins