Fbxo38
entrez
107035
canonical
uniprot
Q8BMI0
canonical
ensembl
ENSMUSG00000042211
resolver
ensp
ENSMUSP00000047541
resolver
ensp
ENSMUSP00000276885
resolver
ensp
ENSMUSP00000276886
resolver
ensp
ENSMUSP00000276887
resolver
ensp
ENSMUSP00000276891
resolver
ensp
ENSMUSP00000276892
resolver
ensp
ENSMUSP00000276896
resolver
ensp
ENSMUSP00000276897
resolver
ensp
ENSMUSP00000276910
resolver
ensp
ENSMUSP00000276921
resolver
enst
ENSMUST00000048688
resolver
genesymbol
Fbxo38
resolver
uniprot
Q8BTQ4
resolver
uniprot
Q8C0H4
resolver
uniprot_entry
FBX38_MOUSE
resolver
uniprot_sec
Q8BTQ4
resolver
uniprot_sec
Q8C0H4
resolver
amino_acid_sequence
MGPRKKSAKVCVMDSEVAEEMTADEEKDYMNQLSHEVLCHIFRYLPLQDIMCMECLSRKLKEAVTLYLRVVRVVDLCAGRWWEYMPSGFTDSSFLTLLKKMPDVEQLYGLHPRYLERRRVRGQEAFSIPGVLEALQACPNLVGVETSHLELVESIWTYMPHVHILGKFRNRNGAFPIPPENKLKIPIGAKIQTLHLVGVNVPEIPCIPMLRHLYMKWVRLTKPQPFKDFLCISLRTFVMRNCAGPTNSLKYVPLVTGLASARNLEHLEMVRVPFLGGLIQHVVEDSWRSGGFRNLHTIVLGACKNALEVDLGYLIITAARRLHEVRIQPSLTKDGVFSALKMAELEFPQFETLHLGYVDEFLLQSRMANADLVKYGLADVVENPGIITDIGMKAVNEVFSCIKYLAIYNCPHLHNPYNWISDHSRWMRLVDINLVRCHALKLDSFGQFVELLPSLEFISLDQMFREPPKGCARVGLSAGTGIGVSSALVSNQNSNNDNDNNAPNNNANLHDNNHHHPDDSDDDNDFRPDLQAGEAQFAADALNEMEDMVQEDGELVAESGNGMPAHNREVLPVDADEEQAGPSGLQRVVKPTPIADHDSESDDEEDSLELQEVWAPKNGTRRYSEREEKTGDSGQSRETAVSGKGKTPLRKRCNNSHQTGQAKPFPLEESSCEKGCQVTSEQIKADMKAARDVSEKKKSKDVYPSCSSSSSSTAASTAGNASSPSTASQSPDFARTVTSSGSSEPSPPEVDVSRQCVCSPGGSEDSEAMEEGDAESSVCPRCCCLRPQESQRRTGRCSDEERPSTSRACVVNGADGTRSAFSFRTLPQGGSSGPAHDERTNGSGCGATGEDRRGSSQPESCDVQSNEDYPRRPLTRARSRLSHVPLISESEVAKTKPCHAMKRKRTADKSTSTSDPVIEDDHVQVLVLKSKNLVGVTMTNCGITDLVLKDCPKMMFIHATRCRVLKHLKVENAPIVNRFDYAQCKKLNMDQVLDQILRMPPERNRIIYLRPMQQVDTLTLEQKLFSGPYPYHICIIHEFSNPPNVRNKVRIRNWMDTIANINQELIKYEFFLEATRTEEDLKKYPKYPWGREIYTLEGVVDGAPYSMISDFPWLRSLRTAEPNSFARYDFEDDEESTIYAPRRKGQLSADICMETIGEEISEMRQMKRGIFQRVVAIFIHYCDVNGEPVEDDYI
uniprot
proteins
function
FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity (PubMed:30487606). Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:30487606). May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination (PubMed:14729953, PubMed:16990251). {ECO:0000269|PubMed:14729953, ECO:0000269|PubMed:16990251, ECO:0000269|PubMed:30487606}.
uniprot
proteins
mass_dalton
133928
uniprot
proteins
mutagenesis
MUTAGEN 194..196; /note="LHL->AHA: Decreased cytoplasmic localization."; /evidence="ECO:0000269|PubMed:16990251"; MUTAGEN 264..275; /note="LEHLEMVRVPFL->AEHAEMVRVPFA: Decreased cytoplasmic localization."; /evidence="ECO:0000269|PubMed:16990251"; MUTAGEN 902..904; /note="KRK->RRR: Impaired nuclear localization."; /evidence="ECO:0000269|PubMed:16990251
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q6PIJ6}.
uniprot
proteins
pubmed
14729953
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16990251
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30487606
uniprot
proteins
sequence_length
1194
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:14729953, ECO:0000269|PubMed:16990251}. Nucleus {ECO:0000269|PubMed:14729953, ECO:0000269|PubMed:16990251}. Note=Accumulates predominantly in the cytosol (PubMed:16990251). Exported from the nucleus in a XPO1/CRM1-dependent manner (PubMed:16990251). {ECO:0000269|PubMed:16990251}.
uniprot
proteins