RHEBL1
entrez
121268
canonical
uniprot
Q8TAI7
canonical
ensembl
ENSG00000167550
resolver
ensp
ENSP00000301068
resolver
ensp
ENSP00000588631
resolver
genesymbol
RHEBL1
resolver
hgnc
HGNC:21166
resolver
uniprot
Q56VH8
resolver
uniprot_entry
REBL1_HUMAN
resolver
uniprot_sec
Q56VH8
resolver
amino_acid_sequence
MPLVRYRKVVILGYRCVGKTSLAHQFVEGEFSEGYDPTVENTYSKIVTLGKDEFHLHLVDTAGQDEYSILPYSFIIGVHGYVLVYSVTSLHSFQVIESLYQKLHEGHGKTRVPVVLVGNKADLSPEREVQAVEGKKLAESWGATFMESSARENQLTQGIFTKVIQEIARVENSYGQERRCHLM
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Binds GTP and exhibits intrinsic GTPase activity (By similarity). May activate NF-kappa-B-mediated gene transcription (PubMed:16328882). Promotes signal transduction through MTOR, activates RPS6KB1, and is a downstream target of the small GTPase-activating proteins TSC1 and TSC2. {ECO:0000250|UniProtKB:Q15382, ECO:0000269|PubMed:12869548, ECO:0000269|PubMed:16098514, ECO:0000269|PubMed:16328882, ECO:0000269|PubMed:17162089}.
uniprot
proteins
mass_dalton
20682
uniprot
proteins
mutagenesis
MUTAGEN 41; /note="N->A: Partially impaired in RPS6K1 activation."; /evidence="ECO:0000269|PubMed:16098514"; MUTAGEN 54; /note="F->A: Partially deficient in guanine nucleotide binding."; /evidence="ECO:0000269|PubMed:16098514"; MUTAGEN 56; /note="L->A: Partially deficient in guanine nucleotide binding."; /evidence="ECO:0000269|PubMed:16098514"; MUTAGEN 60; /note="D->K: Significant decrease in NF-kappa B activation."; /evidence="ECO:0000269|PubMed:16328882"; MUTAGEN 64; /note="Q->L: Constitutively active."; /evidence="ECO:0000269|PubMed:16328882
uniprot
proteins
protein_family
Rheb family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
12869548
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16006564
uniprot
proteins
pubmed
16098514
uniprot
proteins
pubmed
16328882
uniprot
proteins
pubmed
17162089
uniprot
proteins
sequence_length
183
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endomembrane system {ECO:0000305|PubMed:16328882}; Lipid-anchor {ECO:0000305|PubMed:16006564}; Cytoplasmic side {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:16328882}.
uniprot
proteins