Plcz1
entrez
497197
canonical
uniprot
Q5FX52
canonical
ensembl
ENSRNOG00000008514
resolver
ensembl
ENSRNOG00055009010
resolver
ensembl
ENSRNOG00060008098
resolver
ensembl
ENSRNOG00065012010
resolver
ensp
ENSRNOP00000011376
resolver
ensp
ENSRNOP00055012193
resolver
ensp
ENSRNOP00060010199
resolver
ensp
ENSRNOP00065014967
resolver
enst
ENSRNOT00000011376
resolver
enst
ENSRNOT00055015234
resolver
enst
ENSRNOT00060013405
resolver
enst
ENSRNOT00065019531
resolver
genesymbol
Plcz1
resolver
uniprot_entry
PLCZ1_RAT
resolver
amino_acid_sequence
MESHYELAEARWFMSKIQDYFRGGKISAGITHKLLEKLDFPCHFAHVKRIFKENDRHNQGRITTEDFRTIYRCIVHREEIVEIFNTYTENRKILPEDSLIEFLTQEQYEMEMDESSSVEIIQKYEPIAEVKNERQMSIEGFARYMFSSECLLFKETCNTVYQDMNKPLNDYYISSSHNTYLISDQILGPSDIWGYISALVKGCRCLEIDCWDGAQNEPIVYHGYTLTSKLLFKTVIQAINKYAFVTSDYPVVLSLENHCSPGQQEVMTDILQSTFGDFLLSDILDEFPDSLPSPEALKFKILVKNKKVGTLSETRERLGTDKRGIALDLEEEIYENEDEDSGKEPETWDDFLSRVKEEQEADPSTLSGIADAKKKIRKLRVALALSDLVIYTKAEKFRNFQYSRVYQQFNETTSMGESRARKLSKLRAHEFIFHTAAFITRVYPKFTRADSSNFNPQEFWNVGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYVLKPDFLRDTTLGFNPNEPEGDGHPVTLTIRLISGIQLPVNVPSNTSDIIVIIEVYGVPNDHMKQQSRAVKNNAFSPRWNETFTFLIQVPELALIRFVVETQGFLSGNELLGQYTLPVLCMNKGYRRVPLFSKSGANLEPSSLFIYVWYYRE
uniprot
proteins
ec_number
3.1.4.11
uniprot
proteins
function
FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function. {ECO:0000250|UniProtKB:Q86YW0, ECO:0000250|UniProtKB:Q8K4D7, ECO:0000269|PubMed:18322275, ECO:0000305}.
uniprot
proteins
mass_dalton
74315
uniprot
proteins
pubmed
18322275
uniprot
proteins
sequence_length
645
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8K4D7}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8K4D7}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q8K4D7}. Note=Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronucleus at interphase following meiosis and mitosis (By similarity). Expressed at the acrosome and post-acrosome regions in spermatozoa (By similarity). {ECO:0000250|UniProtKB:Q8K4D7}.
uniprot
proteins