Tmem63c
entrez
314332
canonical
uniprot
D3ZNF5
canonical
ensembl
ENSRNOG00000011334
resolver
ensembl
ENSRNOG00055024523
resolver
ensembl
ENSRNOG00060018186
resolver
ensembl
ENSRNOG00065026016
resolver
ensp
ENSRNOP00000079813
resolver
ensp
ENSRNOP00055034420
resolver
ensp
ENSRNOP00060025349
resolver
ensp
ENSRNOP00065036752
resolver
enst
ENSRNOT00000106610
resolver
enst
ENSRNOT00055042187
resolver
enst
ENSRNOT00060031253
resolver
enst
ENSRNOT00065044861
resolver
genesymbol
Tmem63c
resolver
genesymbol_syn
Csc1
resolver
uniprot_entry
TM63C_RAT
resolver
amino_acid_sequence
MTASPESMGQKFRNMTANECFQSRSTVLQGQPFGGIPTVLLLNIILWVCVVLVYSFLRKAAWDYGRLALLIHNDSLTSLIYGEQSEKSSPSEVYLEAERRDKGFSTWFFNSLTMRDRDLINKCGEDARIYIMFQYHLIIFVLILCIPSLGIILPVNYIGSALDWSSHFGRTTIVNVSTESQFLWLHSIFAFMYFLTNFAFMGHHCLGFVPKKNLHFTRTLMITYVPTEIQDPETISKHFHEAYPGCVVTRVHFCYDVRNLIDLDDQRRHAMRGRLYYTAKAKKTGKVMIKVHPCSHLCFCKCWTCFKEVDAEQYYSELEEQLTDEFNAELNRVQLKRLDLIFVTFQDARTVKRIHNDYKYINCGRHPMQSSVTTIVKNNHWRVARAPHPKDIIWKHLSIRRFSWWARFIAINTSLFFLFFFLTTPAIIINTIDMYNVTRPIEKLQSPVVTQFFPSVLLWAFTVIMPLLVYFSAFLEAHWTRSNQNLIIMYKCYIFLVFMVVILPSMGLTSLDVFLRWLFDIYYLEHATIRFQCVFLPDNGAFFINYVITSALFGTGMELMRLGSLCTYCTRLFLSRSEPERVHIRKNLAMDFQFGREYAWMLNVFSVVMAYSITCPIIVPFGLLYLCMKHITDRYNMYYSYAPTKLNAQIHMAAVYQAIFAPLLGLFWMLFFSILRVGSLHSITLFSLSSIIISVIIAFSGVFLGKFRIAQQYEQPEEETETVFDVEPSSTTSTPTSLLYVATVLQEPELNLTPASSPARHTYGTMNSQPEEGEEESGLRGFARELDPAQFQEGLELEGQSH
uniprot
proteins
function
FUNCTION: Acts as an osmosensitive cation channel preferentially activated upon hypotonic stress (By similarity). In contrast to TMEM63B, does not show phospholipid scramblase activity (By similarity). Enriched in mitochondria-ER contact sites where it may regulate the metabolite flux and organelles' morphologies in response to osmotic changes (By similarity). In particular may regulate mitochondrial motility and function in motor neuron axons (By similarity). Required for the functional integrity of the kidney glomerular filtration barrier (PubMed:30900988). {ECO:0000250|UniProtKB:Q9P1W3, ECO:0000269|PubMed:30900988}.
uniprot
proteins
mass_dalton
92962
uniprot
proteins
protein_family
CSC1 (TC 1.A.17) family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
30900988
uniprot
proteins
sequence_length
802
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9P1W3}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q8CBX0}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes at mitochondria-ER contact sites. {ECO:0000250|UniProtKB:Q9P1W3}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..60; /note="Helical; Name=TM0"; /evidence="ECO:0000250|UniProtKB:Q8CBX0"; TRANSMEM 125..157; /note="Helical; Name=TM1"; /evidence="ECO:0000250|UniProtKB:Q8CBX0"; TRANSMEM 181..205; /note="Helical; Name=TM2"; /evidence="ECO:0000250|UniProtKB:Q8CBX0"; TRANSMEM 402..431; /note="Helical; Name=TM3"; /evidence="ECO:0000250|UniProtKB:Q8CBX0"; TRANSMEM 447..476; /note="Helical; Name=TM4"; /evidence="ECO:0000250|UniProtKB:Q8CBX0"; TRANSMEM 481..517; /note="Helical; Name=TM5"; /evidence="ECO:0000250|UniProtKB:Q8CBX0"; TRANSMEM 541..573; /note="Helical; Name=TM6"; /evidence="ECO:0000250|UniProtKB:Q8CBX0"; TRANSMEM 594..612; /note="Helical; Name=TM7"; /evidence="ECO:0000250|UniProtKB:Q8CBX0"; TRANSMEM 616..640; /note="Helical; Name=TM8"; /evidence="ECO:0000250|UniProtKB:Q8CBX0"; TRANSMEM 648..676; /note="Helical; Name=TM9"; /evidence="ECO:0000250|UniProtKB:Q8CBX0"; TRANSMEM 682..702; /note="Helical; Name=TM10"; /evidence="ECO:0000250|UniProtKB:Q8CBX0
uniprot
proteins