Trim50
entrez
215061
canonical
uniprot
Q810I2
canonical
ensembl
ENSMUSG00000053388
resolver
ensp
ENSMUSP00000066662
resolver
ensp
ENSMUSP00000106811
resolver
enst
ENSMUST00000065785
resolver
enst
ENSMUST00000111180
resolver
genesymbol
Trim50
resolver
uniprot
E9PVV5
resolver
uniprot_entry
E9PVV5_MOUSE
resolver
uniprot_entry
TRI50_MOUSE
resolver
amino_acid_sequence
MAWRLTVPELQDQLQCPICLEVFKEPLMLQCGHSYCKDCLDNLSQHLDSELCCPVCRQSVDCSSSPPNVSLARVIDALRLPGDIEPTVCVHHRNPLSLFCEKDQEFICGLCGLLGSHQHHRVTPVSTVYSRMKEELAGRISELKEEHRNVEEHIGKLVNNRTRIINESDVFSWVIRREFQELHHLVDEEKARCLEGLEGHTRGLVASLDMQLEQAQGTQERLAQAEQVLEQFGNESHHEFIRFHSVASRAEVQQARPLEGVFSPISFKPALHQADIKLTVWKRLFRKVLPAPASLKLDPATAHPLLELSKGNTVVHCGLLAQRRASQPERFDYSTCVLASKGFSWGRHYWEVVVGSKSDWRLGVIKGTASRKGKLNKSPEHGVWLIGLKEGRVYEAFGCPRLPLPVAGHPHRIGVYLHYEQGELTFFDADRPDDLRTLYTFQADFQGKLYPILDTCWHERGSNSLPMVLPPPSGPGHFTLGQV
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1 (PubMed:29604308). In turn, promotes starvation-induced autophagy activation. Also interacts with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction (PubMed:22792322). Also promotes NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization independent of its E3 ligase function (PubMed:36178239). {ECO:0000269|PubMed:22792322, ECO:0000269|PubMed:29604308, ECO:0000269|PubMed:36178239}.
uniprot
proteins
mass_dalton
54607
uniprot
proteins
mutagenesis
MUTAGEN 372; /note="K->R: Complete loss of acetylation."; /evidence="ECO:0000269|PubMed:24308962
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated. {ECO:0000250|UniProtKB:Q86XT4}.; PTM: Acetylated by EP300 and KAT2B. HDAC6 drives TRIM50 deacetylation. Acetylation antagonizes with TRIM50 ubiquitination. {ECO:0000269|PubMed:24308962}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
18398435
uniprot
proteins
pubmed
22792322
uniprot
proteins
pubmed
24308962
uniprot
proteins
pubmed
29604308
uniprot
proteins
pubmed
36178239
uniprot
proteins
sequence_length
483
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22792322, ECO:0000269|PubMed:24308962, ECO:0000269|PubMed:29604308, ECO:0000269|PubMed:36178239}. Note=Localizes mainly into discrete cytoplasmic punctuate structures heterogeneous in size and shape containing polyubiquitinated proteins. {ECO:0000269|PubMed:22792322}.
uniprot
proteins