RAP2B
entrez
5912
canonical
uniprot
P61225
canonical
ensembl
ENSG00000181467
resolver
ensp
ENSP00000319096
resolver
enst
ENST00000323534
resolver
genesymbol
RAP2B
resolver
hgnc
HGNC:9862
resolver
uniprot
P17964
resolver
uniprot
Q96EG5
resolver
uniprot
Q9CXG0
resolver
uniprot_entry
RAP2B_HUMAN
resolver
uniprot_sec
P17964
resolver
uniprot_sec
Q96EG5
resolver
uniprot_sec
Q9CXG0
resolver
amino_acid_sequence
MREYKVVVLGSGGVGKSALTVQFVTGSFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYERVPMILVGNKVDLEGEREVSYGEGKALAEEWSCPFMETSAKNKASVDELFAEIVRQMNYAAQPNGDEGCCSACVIL
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells. {ECO:0000269|PubMed:11877431, ECO:0000269|PubMed:15143162, ECO:0000269|PubMed:16540189}.
uniprot
proteins
mass_dalton
20504
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. Unlike RAP2A and RAP2C, palmitoylation of RAP2B is not required for association with recycling endosome membranes and activation of TNIK. {ECO:0000250|UniProtKB:P61226}.
uniprot
proteins
protein_family
Ras family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
11877431
uniprot
proteins
pubmed
12444546
uniprot
proteins
pubmed
15143162
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16540189
uniprot
proteins
pubmed
17509819
uniprot
proteins
pubmed
2115998
uniprot
proteins
pubmed
2118648
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
8424780
uniprot
proteins
sequence_length
183
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000269|PubMed:16540189}; Lipid-anchor {ECO:0000269|PubMed:16540189}; Cytoplasmic side {ECO:0000269|PubMed:16540189}. Note=Associated with red blood cells-released vesicles.
uniprot
proteins