Stxbp1
entrez
25558
canonical
uniprot
P61765
canonical
ensembl
ENSRNOG00000015420
resolver
ensembl
ENSRNOG00055006218
resolver
ensembl
ENSRNOG00060033109
resolver
ensembl
ENSRNOG00065025474
resolver
ensp
ENSRNOP00000021178
resolver
genesymbol
Stxbp1
resolver
genesymbol_syn
Unc18a
resolver
uniprot
Q28208
resolver
uniprot
Q62759
resolver
uniprot
Q64320
resolver
uniprot
Q96TG8
resolver
uniprot_entry
STXB1_RAT
resolver
uniprot_sec
Q28208
resolver
uniprot_sec
Q62759
resolver
uniprot_sec
Q64320
resolver
uniprot_sec
Q96TG8
resolver
amino_acid_sequence
MAPIGLKAVVGEKIMHDVIKKVKKKGEWKVLVVDQLSMRMLSSCCKMTDIMTEGITIVEDINKRREPLPSLEAVYLITPSEKSVHSLISDFKDPPTAKYRAAHVFFTDSCPDALFNELVKSRAAKVIKTLTEINIAFLPYESQVYSLDSADSFQSFYSPHKAQMKNPILERLAEQIATLCATLKEYPAVRYRGEYKDNALLAQLIQDKLDAYKADDPTMGEGPDKARSQLLILDRGFDPSSPVLHELTFQAMSYDLLPIENDVYKYETSGIGEARVKEVLLDEDDDLWIALRHKHIAEVSQEVTRSLKDFSSSKRMNTGEKTTMRDLSQMLKKMPQYQKELSKYSTHLHLAEDCMKHYQGTVDKLCRVEQDLAMGTDAEGEKIKDPMRAIVPILLDANVSTYDKIRIILLYIFLKNGITEENLNKLIQHAQIPPEDSEIITNMAHLGVPIVTDSTLRRRSKPERKERISEQTYQLSRWTPIIKDIMEDTIEDKLDTKHYPYISTRSSASFSTTAVSARYGHWHKNKAPGEYRSGPRLIIFILGGVSLNEMRCAYEVTQANGKWEVLIGSTHILTPQKLLDTLKKLNKTDEEISS
uniprot
proteins
function
FUNCTION: Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (PubMed:21689256). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synaptic membranes (By similarity). May play a role in determining the specificity of intracellular fusion reactions. {ECO:0000250|UniProtKB:O08599, ECO:0000269|PubMed:21689256}.
uniprot
proteins
mass_dalton
67569
uniprot
proteins
protein_family
STXBP/unc-18/SEC1 family
uniprot
proteins
pubmed
10746715
uniprot
proteins
pubmed
12058058
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21689256
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7536802
uniprot
proteins
pubmed
7698978
uniprot
proteins
pubmed
8108429
uniprot
proteins
pubmed
8134339
uniprot
proteins
pubmed
8247129
uniprot
proteins
sequence_length
594
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P61764}. Membrane; Peripheral membrane protein.
uniprot
proteins