Ptf1a
entrez
117034
canonical
uniprot
Q64305
canonical
ensembl
ENSRNOG00000016902
resolver
ensembl
ENSRNOG00055011307
resolver
ensembl
ENSRNOG00060020572
resolver
ensembl
ENSRNOG00065003124
resolver
ensp
ENSRNOP00000022727
resolver
ensp
ENSRNOP00055015422
resolver
ensp
ENSRNOP00060029281
resolver
ensp
ENSRNOP00065003133
resolver
enst
ENSRNOT00000022727
resolver
enst
ENSRNOT00055019148
resolver
enst
ENSRNOT00060035615
resolver
enst
ENSRNOT00065004396
resolver
genesymbol
Ptf1a
resolver
genesymbol_syn
Ptf1p48
resolver
uniprot_entry
PTF1A_RAT
resolver
amino_acid_sequence
MDAVLLEHFPGALDTFPSSYFDEEDFFTDQSSRDPLEDGDELLGDEQAEVEFLSHQLHEYCYRDGACLLLQPAPSAAPHALAPPPLGDPGEPEDSGSYCCDAGAPLGAFPYSPGSPPSCLAYPCTAVLSPGTRLRGLNGAAAAAAAAARRRRRVRSEAELQQLRQAANVRERRRMQSINDAFEGLRSHIPTLPYEKRLSKVDTLRLAIGYINFLSELVQADLPLRGSGTGGCGGPGGSRHLGGDSPGNQAQKVIICHRGTRSPSPSDPDYGLPPLAGHSLSWADEKQLKEQNIIRTAKVWTPEDPRKLNSKSFDNIENEPPFEFVS
uniprot
proteins
function
FUNCTION: Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates. {ECO:0000269|PubMed:10768861, ECO:0000269|PubMed:8703005, ECO:0000269|PubMed:8861960}.
uniprot
proteins
mass_dalton
35305
uniprot
proteins
pubmed
10768861
uniprot
proteins
pubmed
8703005
uniprot
proteins
pubmed
8861960
uniprot
proteins
sequence_length
326
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:8861960}. Cytoplasm {ECO:0000269|PubMed:8861960}. Note=In the cytoplasm loses its ability to form the PTF1 complex.
uniprot
proteins