COX7B2
entrez
170712
canonical
uniprot
Q8TF08
canonical
ensembl
ENSG00000170516
resolver
ensp
ENSP00000347799
resolver
ensp
ENSP00000379784
resolver
ensp
ENSP00000766592
resolver
ensp
ENSP00000766596
resolver
enst
ENST00000355591
resolver
enst
ENST00000396533
resolver
genesymbol
COX7B2
resolver
hgnc
HGNC:24381
resolver
uniprot
Q32Q40
resolver
uniprot_entry
CX7B2_HUMAN
resolver
uniprot_sec
Q32Q40
resolver
amino_acid_sequence
MMFPLARNALSSLKIQSILQSMARHSHVKHSPDFHDKYGNAVLASGTAFCVATWVFTATQIGIEWNLSPVGRVTPKEWKHQ
uniprot
proteins
function
FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P13183}.
uniprot
proteins
mass_dalton
9077
uniprot
proteins
pathway_participation
PATHWAY: Energy metabolism; oxidative phosphorylation. {ECO:0000250|UniProtKB:P13183}.
uniprot
proteins
protein_family
Cytochrome c oxidase VIIb family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15623157
uniprot
proteins
sequence_length
81
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P13183}; Single-pass membrane protein {ECO:0000250|UniProtKB:P13183}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..60; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P13183
uniprot
proteins