Ltn1
entrez
78913
canonical
uniprot
Q6A009
canonical
ensembl
ENSMUSG00000052299
resolver
ensp
ENSMUSP00000038775
resolver
enst
ENSMUST00000039449
resolver
genesymbol
Ltn1
resolver
genesymbol_syn
Kiaa0714
resolver
genesymbol_syn
Lister
resolver
genesymbol_syn
Rnf160
resolver
genesymbol_syn
Zfp294
resolver
genesymbol_syn
Znf294
resolver
uniprot
E9QN94
resolver
uniprot
Q6PIW6
resolver
uniprot
Q8BZ44
resolver
uniprot_entry
LTN1_MOUSE
resolver
uniprot_sec
E9QN94
resolver
uniprot_sec
Q6PIW6
resolver
uniprot_sec
Q8BZ44
resolver
amino_acid_sequence
MGGKNKQRTKGNLRPSNSGRAAELLAKEQGTVPGFIGFGTSHSDLGYVPAVQGAEDIDSLVDSDFRMVLRKLSKKDVTTKLKAMQEFGIMCTERDTEAVKGVLPYWPRIFCKISLDHDRRVREATQQAFEKLILKVKKHLAPYLKSVMGYWLMAQCDTYPPAALAAKDAFEAAFPPSKQPEAIAFCKEEITTVLQDHLLKETPDTLSDPQTVPEEEREAKFHRVVTCSLLALKRLLCFLPNNELDSLEEKFKSLLSQNKFWKYGKHSVPQVRSAYFELVSALCQHVPQVMKEEAAKVSPSVLLSIDDSDPVVCPALWEAVLYTLTTIEDCWFHVNAKKSVFPKLMAMIREGGRGLAAVMYPYLLPFISKLPQSITEPKLDFFKNFLTSLVTGLSTERTKSSSSECSAVISAFFECLRFIMQQNLGEEEMVQMLINEQLIPFIDTVLKDSGLHHGPMFDHLADTLSSWEAKADAERDPGAVYNLENVLLSFWGRLSEICTEKIRQPEADVKSVLCVSSLVGVLQRPRSSLKLHRKKTAQVRFAINIPEAHKGDEKSMSSEGENSEGSDGGAQSPLSNTSSDLVSPLRKKPLEDLVCKLAEVSISFVNERKSEQHLQFLSTLLDSFSSVQVFNILLSDKQKNVVKAKPLEITKLAEKNPAVKFLYHKLIGWLNDSQKEDGGFLVDILYSALRCCDSGVERKEVLDDLTKEDLKWSSLLQVIEKACSSSDKHALVTPWLKGSILGEKLVALADCLCDKDLEATTSESHSSEQWSLLRLALSQHVKNDYLIGEVYVGRIIVKLHETLSKTKDLSEAANSDSSVSFVCDVVHSFFSSAGGGLLMPPSEDLLLTLFQLCAQSKERTHLPDFLICKLKNTLLSGVNLLVHQTASTYEQSTFLRLSVLWLKDQVQSSALDNTSLQVLLSAAGDLLGTLVESEDTSLLGVYIGSVMPSDSEWEKMRQALPVQWLHRPLLEGRLSLNYECFKTDFKEQDTKTLPNHLCTSSLLSKMILVAQKKKLVLEDNVLEKIIAELLYSLQWCEELDNAPSFLSGFCGILQKMNITYSNLSVLSETSSLLQLLFDRSRKNGTLWSLIIAKLILSRSISSDEVKPYYKRKESFFPLTEGSLHTIQSLCPFLSKEEKKEFSAQCIPAFLGWTKEDLCSINGAFGHLAIFNSCLQTRSIDDKQLLHGILKIITSWRKQHEDIFLFSCNLSEASPEVLGLNIEIMRFLSLFLKHCAYPLPLADSEWDFIMCSMLAWLETTSENQALYSVPLVQLFACVSFDLACDLCAFFDSITPDIVDNLPVNLISEWKEFFSKGIHSLLLPLLVNAIGENKDLSETSFQNAMLKPMCETLTYISKDQLLSHKLPARLVASQKTNLPEHLQTLLNTLTPLLLFRARPVQIAAYHMLCKLMPELPQHDQDNLRSYGDEEEEPALSPPAALMSLLSSQEELLENVLGCVPVGQIVTVKPLSEDFCYVLGYLLTWKLILTFFKAASSQLRALYSMYLRKTKSLNKLLYHLFRLMPENPTYGETAIEVSSKDPKTFFTEEVQLSIRETATLPYHIPHLACSVYHMTLKDLPAMVRLWWNSSEKRVFNIVDRFTSKYVSNVLSFQEISSVQTSTQLFNGMTVKARATTREVMATYTIEDIVIELIIQLPSNYPLGSITVESGKRIGVAVQQWRNWMLQLSTYLTHQNGSIMEGLALWKNNVDKRFEGVEDCMICFSVIHGFNYSLPKKACRTCKKKFHSACLYKWFTSSNKSTCPLCRETFF
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase (PubMed:19196968). component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (By similarity). Within the RQC complex, LTN1 is recruited to stalled 60S ribosomal subunits by NEMF and mediates ubiquitination of stalled nascent chains (By similarity). Ubiquitination leads to VCP/p97 recruitment for extraction and degradation of the incomplete translation product (By similarity). {ECO:0000250|UniProtKB:O94822, ECO:0000250|UniProtKB:Q04781, ECO:0000269|PubMed:19196968}.
uniprot
proteins
mass_dalton
198921
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:19196968}.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. {ECO:0000269|PubMed:19196968}.
uniprot
proteins
protein_family
LTN1 family
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19196968
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1767
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O94822}.
uniprot
proteins