RPS7
entrez
6201
canonical
uniprot
P62081
canonical
ensembl
ENSG00000171863
resolver
ensp
ENSP00000385018
resolver
ensp
ENSP00000385286
resolver
ensp
ENSP00000495273
resolver
ensp
ENSP00000496654
resolver
ensp
ENSP00000496757
resolver
ensp
ENSP00000576036
resolver
ensp
ENSP00000590347
resolver
ensp
ENSP00000590349
resolver
ensp
ENSP00000590350
resolver
ensp
ENSP00000590367
resolver
enst
ENST00000403564
resolver
enst
ENST00000406376
resolver
enst
ENST00000462576
resolver
enst
ENST00000645674
resolver
enst
ENST00000646909
resolver
enst
ENST00000905977
resolver
enst
ENST00000920288
resolver
enst
ENST00000920290
resolver
enst
ENST00000920291
resolver
enst
ENST00000920308
resolver
genesymbol
RPS7
resolver
hgnc
HGNC:10440
resolver
uniprot
P23821
resolver
uniprot
P24818
resolver
uniprot
Q57Z92
resolver
uniprot
Q6IPH1
resolver
uniprot_entry
RS7_HUMAN
resolver
uniprot_sec
P23821
resolver
uniprot_sec
P24818
resolver
uniprot_sec
Q57Z92
resolver
uniprot_sec
Q6IPH1
resolver
amino_acid_sequence
MFSSSAKIVKPNGEKPDEFESGISQALLELEMNSDLKAQLRELNITAAKEIEVGGGRKAIIIFVPVPQLKSFQKIQVRLVRELEKKFSGKHVVFIAQRRILPKPTRKSRTKNKQKRPRSRTLTAVHDAILEDLVFPSEIVGKRIRVKLDGSRLIKVHLDKAQQNNVEHKVETFSGVYKKLTGKDVNFEFPEFQL
uniprot
proteins
disease_involvement
DISEASE: Diamond-Blackfan anemia 8 (DBA8) [MIM:612563]: An autosomal dominant form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies. {ECO:0000269|PubMed:19061985}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for rRNA maturation (PubMed:19061985). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:19061985, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:34516797}.
uniprot
proteins
mass_dalton
22127
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by NEK6. {ECO:0000269|PubMed:20873783}.; PTM: Ubiquitinated. Deubiquitinated by DESI2, leading to its stabilization. {ECO:0000269|PubMed:28483520}.
uniprot
proteins
protein_family
Eukaryotic ribosomal protein eS7 family
uniprot
proteins
pubmed
11823430
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19061985
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20873783
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23636399
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24524803
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28483520
uniprot
proteins
pubmed
34516797
uniprot
proteins
pubmed
8522193
uniprot
proteins
pubmed
8706699
uniprot
proteins
pubmed
9687515
uniprot
proteins
sequence_length
194
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:20873783}. Cytoplasm {ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:9687515}. Nucleus, nucleolus {ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:9687515}. Note=Although RPS7 is functional within the cytoplasm, the assembly of ribosomal subunits occurs in the nucleus. RPS7 nuclear import is mediated by IPO5/RanBP5, IPO7/RanBP7, KPNB1/importin-beta or TPNO1/Trn (PubMed:9687515). Colocalizes with NEK6 in the centrosome (PubMed:20873783). {ECO:0000269|PubMed:20873783, ECO:0000269|PubMed:9687515}.
uniprot
proteins