CASP9
entrez
842
canonical
uniprot
P55211
canonical
ensembl
ENSG00000132906
resolver
ensp
ENSP00000255256
resolver
ensp
ENSP00000330237
resolver
ensp
ENSP00000365051
resolver
ensp
ENSP00000449584
resolver
enst
ENST00000546424
resolver
genesymbol
CASP9
resolver
genesymbol_syn
MCH6
resolver
hgnc
HGNC:1511
resolver
uniprot
B4E1A3
resolver
uniprot
F8VVS7
resolver
uniprot
O95348
resolver
uniprot
Q53Y70
resolver
uniprot
Q5JRU9
resolver
uniprot
Q5UGI1
resolver
uniprot
Q92852
resolver
uniprot
Q9BQ62
resolver
uniprot
Q9UEQ3
resolver
uniprot
Q9UIJ8
resolver
uniprot_entry
CASP9_HUMAN
resolver
uniprot_entry
F8VVS7_HUMAN
resolver
uniprot_sec
B4E1A3
resolver
uniprot_sec
O95348
resolver
uniprot_sec
Q53Y70
resolver
uniprot_sec
Q5JRU9
resolver
uniprot_sec
Q5UGI1
resolver
uniprot_sec
Q92852
resolver
uniprot_sec
Q9BQ62
resolver
uniprot_sec
Q9UEQ3
resolver
uniprot_sec
Q9UIJ8
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by the effector protein NleF that is produced by pathogenic E.coli; this inhibits apoptosis (PubMed:23516580). Inhibited by BIRC6; following inhibition of BIRC6-caspase binding by DIABLO/SMAC, BIRC6 is subjected to caspase cleavage, leading to an increase in active caspases (PubMed:36758105, PubMed:36758106). {ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:36758105, ECO:0000269|PubMed:36758106}.
uniprot
proteins
amino_acid_sequence
MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGSRRDQARQLIIDLETRGSQALPLFISCLEDTGQDMLASFLRTNRQAAKLSKPTLENLTPVVLRPEIRKPEVLRPETPRPVDIGSGGFGDVGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACGGEQKDHGFEVASTSPEDESPGSNPEPDATPFQEGLRTFDQLDAISSLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQWAHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
uniprot
proteins
ec_number
3.4.22.62
uniprot
proteins
function
FUNCTION: Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (PubMed:36758105, PubMed:36758106). {ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:16352606, ECO:0000269|PubMed:16916640, ECO:0000269|PubMed:23516580, ECO:0000269|PubMed:27889207, ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120}.; FUNCTION: [Isoform 2]: Lacks activity is an dominant-negative inhibitor of caspase-9. {ECO:0000269|PubMed:10070954}.
uniprot
proteins
mass_dalton
46281
uniprot
proteins
mutagenesis
MUTAGEN 153; /note="Y->F: Inhibits tyrosine phosphorylation. Reduces caspase-9 subunit p35 formation in response to genotoxic stress. Attenuates ABL1/c-Abl-mediated caspase-3 activation, DNA fragmentation and UV irradiation-induced apoptosis."; /evidence="ECO:0000269|PubMed:15657060"; MUTAGEN 355; /note="R->A: Abolished ADP-riboxanation by C.violaceum CopC."; /evidence="ECO:0000269|PubMed:35446120
uniprot
proteins
post_translational_modification
PTM: Cleavages at Asp-315 by granzyme B and at Asp-330 by caspase-3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events.; PTM: Phosphorylated at Thr-125 by MAPK1/ERK2. Phosphorylation at Thr-125 is sufficient to block caspase-9 processing and subsequent caspase-3 activation. Phosphorylation on Tyr-153 by ABL1/c-Abl; occurs in the response of cells to DNA damage. {ECO:0000269|PubMed:12792650, ECO:0000269|PubMed:15657060}.; PTM: (Microbial infection) ADP-riboxanation by C.violaceum CopC blocks CASP9 processing, preventing CASP9 activation and ability to mediate intrinsic apoptosis. {ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120}.; PTM: Ubiquitinated by BIRC6; this activity is inhibited by DIABLO/SMAC. {ECO:0000269|PubMed:36758105, ECO:0000269|PubMed:36758106}.
uniprot
proteins
protein_family
Peptidase C14A family
uniprot
proteins
pubmed
10070954
uniprot
proteins
pubmed
10384055
uniprot
proteins
pubmed
11734640
uniprot
proteins
pubmed
12620238
uniprot
proteins
pubmed
12792650
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15200957
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15657060
uniprot
proteins
pubmed
16352606
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16780893
uniprot
proteins
pubmed
16857965
uniprot
proteins
pubmed
16916640
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19118655
uniprot
proteins
pubmed
19255499
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23516580
uniprot
proteins
pubmed
27889207
uniprot
proteins
pubmed
35338844
uniprot
proteins
pubmed
35446120
uniprot
proteins
pubmed
36758105
uniprot
proteins
pubmed
36758106
uniprot
proteins
pubmed
8663294
uniprot
proteins
pubmed
8900201
uniprot
proteins
pubmed
9890966
uniprot
proteins
sequence_length
416
uniprot
proteins