Slc18a1
entrez
25693
canonical
uniprot
Q01818
canonical
ensembl
ENSRNOG00000011992
resolver
ensp
ENSRNOP00000016193
resolver
enst
ENSRNOT00000016193
resolver
genesymbol
Slc18a1
resolver
genesymbol_syn
Cgat
resolver
genesymbol_syn
Vmat1
resolver
uniprot
F1LSA7
resolver
uniprot_entry
F1LSA7_RAT
resolver
uniprot_entry
VMAT1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Strongly inhibited by reserpine, ketanserin and methamphetamine. Also inhibited weakly by tetrabenazine. {ECO:0000269|PubMed:1505023, ECO:0000269|PubMed:8125935}.
uniprot
proteins
amino_acid_sequence
MLQVVLGAPQRLLKEGRQSRKLVLVVVFVALLLDNMLLTVVVPIVPTFLYATEFKDSNSSLHRGPSVSSQQALTSPAFSTIFSFFDNTTTTVEEHVPFRVTWTNGTIPPPVTEASSVPKNNCLQGIEFLEEENVRIGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASVYTDNYERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQLCILWPSKVSPESAMGTSLLTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVGISLLCVPLAHNIFGLIGPNAGLGFAIGMVDSSLMPIMGYLVDLRHTSVYGSVYAIADVAFCVGFAIGPSTGGVIVQVIGFPWLMVIIGTINIIYAPLCCFLQNPPAKEEKRAILSQECPTETQMYTFQKPTKAFPLGENSDDPSSGE
uniprot
proteins
function
FUNCTION: Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports catecholamines and indolamines with higher affinity for serotonin (PubMed:1505023, PubMed:8125935). Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates presynaptic monoaminergic vesicle transport in the amygdala and prefrontal brain regions related with emotion processing in response to environmental stimuli (By similarity). {ECO:0000250|UniProtKB:P54219, ECO:0000269|PubMed:1505023, ECO:0000269|PubMed:8125935}.
uniprot
proteins
mass_dalton
55935
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Vesicular transporter family
uniprot
proteins
pubmed
1505023
uniprot
proteins
pubmed
8125935
uniprot
proteins
sequence_length
521
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:P54219}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q8R090}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 136..155; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 165..185; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 195..215; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 225..247; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 254..276; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 297..316; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 333..357; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 363..383; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 395..415; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 420..440; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 446..467; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins