Ccl2
entrez
20296
canonical
uniprot
P10148
canonical
ensembl
ENSMUSG00000035385
resolver
ensp
ENSMUSP00000000193
resolver
enst
ENSMUST00000000193
resolver
genesymbol
Ccl2
resolver
genesymbol_syn
Je
resolver
genesymbol_syn
Mcp1
resolver
genesymbol_syn
Scya2
resolver
uniprot
Q5SVU3
resolver
uniprot
Q9QYD7
resolver
uniprot_entry
CCL2_MOUSE
resolver
uniprot_entry
Q5SVU3_MOUSE
resolver
uniprot_sec
Q9QYD7
resolver
amino_acid_sequence
MQVPVMLLGLLFTVAGWSIHVLAQPDAVNAPLTCCYSFTSKMIPMSRLESYKRITSSRCPKEAVVFVTKLKREVCADPKKEWVQTYIKNLDRNQMRSEPTTLFKTASALRSSAPLNVKLTRKSEANASTTFSTTTSSTSVGVTSVTVN
uniprot
proteins
function
FUNCTION: Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (PubMed:29993042). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (PubMed:29993042). {ECO:0000250|UniProtKB:P13500, ECO:0000269|PubMed:29993042}.
uniprot
proteins
mass_dalton
16326
uniprot
proteins
post_translational_modification
PTM: Processing at the N-terminus can regulate receptor and target cell selectivity (By similarity). Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant (By similarity). {ECO:0000250|UniProtKB:P13500}.; PTM: N-Glycosylated. {ECO:0000250|UniProtKB:P13500}.
uniprot
proteins
protein_family
Intercrine beta (chemokine CC) family
uniprot
proteins
pubmed
10438970
uniprot
proteins
pubmed
2065676
uniprot
proteins
pubmed
23233732
uniprot
proteins
pubmed
2910858
uniprot
proteins
pubmed
29993042
uniprot
proteins
pubmed
3287374
uniprot
proteins
sequence_length
148
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P13500}.
uniprot
proteins