Abca7
entrez
299609
canonical
uniprot
Q7TNJ2
canonical
ensembl
ENSRNOG00000012939
resolver
ensembl
ENSRNOG00055032600
resolver
ensembl
ENSRNOG00060024048
resolver
ensembl
ENSRNOG00065019847
resolver
ensp
ENSRNOP00000063805
resolver
ensp
ENSRNOP00000085552
resolver
ensp
ENSRNOP00055046466
resolver
ensp
ENSRNOP00060034559
resolver
ensp
ENSRNOP00065026761
resolver
enst
ENSRNOT00000064886
resolver
enst
ENSRNOT00000097711
resolver
enst
ENSRNOT00055056345
resolver
enst
ENSRNOT00060041695
resolver
enst
ENSRNOT00065033462
resolver
genesymbol
Abca7
resolver
uniprot
A0A8I6A4A6
resolver
uniprot
F1LR67
resolver
uniprot_entry
A0A8I6A4A6_RAT
resolver
uniprot_entry
ABCA7_RAT
resolver
uniprot_entry
F1LR67_RAT
resolver
amino_acid_sequence
MAFCTQLMLLLWKNYTYRRRQPIQLVVELLWPLFLFFILVAVRHSHPPLEHHECHFPNKPLPSAGTVPWLQGLVCNVNNSCFQHPTPGEKPGVLSNFKDSLISRLLADAHTVLGGHSTQDMLAALGKLIPVLRAVGSGAWPQESNQPAKQGSVTELLEKILQRASLETVLGQAQDSMRKFSDATRTVAQELLTLPSLVELRALLRRPRGSAGSLELISEALCSTKGPSSPGGLSLNWYEANQINEFMGPELAPTLPDSSLSPACSEFVGALDDHPVSRLLWRRLKPLILGKILFAPDTNFTRKLMAQVNQTFEELALLRDLHELWGVLGPQIFNFMNDSTNVAMLQKLLDVEGTGWQQQTPKGQKQLEAIRDFLDPSRGRYNWQEAHADMGRLAEILGQILECVSLDKLEAVPSEEALVSRALELLGERRLWAGIVFLSPEHPLDSSEPPSPTTTGPGHLRVKIRMDIDDVTRTNKIRDKFWDPGPSADPLMDLRYVWGGFVYLQDLLEQAAVRVLSGRDSRAGLYLQQMPHPCYVDDVFLRVLSRSLPLFLTLAWIYSVALTVKAVVREKETRLRETMRAMGLSRAVLWLGWFLSCLGPFLVSAALLVLVLKLGNILPYSHPVVVFLFLAAFAVATVAQSFLLSAFFSRANLAAACGGLAYFALYLPYVLCVAWRERLPLGGLLAVSLLSPVAFGFGCESLALLEEQGDGAQWHNLGTGPAEDVFSLAQVSAFLLLDAVIYGLALWYLEAVCPGQYGIPEPWNFPFRRSYWCGPGPPKSSVLAPAPQDPKVLVEEPPPGLVPGVSIRGLKKHFRGSPQPALRGLNLDFYEGHITAFLGHNGAGKTTTLSILSGLFPPSSGSASILGHDVQTNMAAIRPHLGICPQYNVLFDMLTVEEHVWFYGRLKGVSAAAIDSEQEHLIRDVGLIPKRDTQTRHLSGGMQRKLSVAIAFVGGSRVVIMDEPTAGVDPASRRGIWELLLKYREGRTLILSTHHLDEAELLGDRVAMVASGSLCCCGSPLFLRRHLGCGYYLTLVKSSQSLVTHDLKGDTEDPRREKKSGSEGKTADTVLTRDGPHRSSQVPAPDAVPVTPSAALILELVQRHVPGAQLVEELPHELVLALPYAGALDGSFATVFQELDQQLERLGLTGYGISDTNLEEIFLKVVEEAHAHGEGGDPRQQQHLLTATPQPHTGPEASVLENGELAKLVLDPQAPKGSAPTTAQVQGWTLTCQQLRALLHKRFLLARRSRRGLFAQIVLPALFVGLALFFTLIVPPFGQYPPLQLSPAMYGPQVSFFSEDAPADPNRMKLLEALLGEAGLQDPSVQGKGSRGSECTHSLACYFTVPEVPPDVASILASGNWTPDSPSPACQCSQPGARRLLPDCPAGAGGPPPPQAMAGFGEVVQNLTGRNVSDFLVKTYPSLVRRGLKTKKWVDEVRYGGFSLGGRDPDLPSGREVVRTVAEMRALLSPQPGNTLDRILNNLTQWALGLDARNSLKIWFNNKGWHAMVAFVNRANNGLLRAFLPSGSVRHAHSITTLNHPLNLTKEQLSEATLIASSVDVLVSICVVFAMSFVPASFTLVLIEERITRAKHLQLVSGLPQTLYWLGNFLWDMCNYLVAVCIVVLIFLAFQQKAYVAPENLPALLLLLLLYGWSITPLMYPASFFFSVPSTAYVVLTCINLFIGINSSMATFVLELLSDQNLQEVSRILKQVFLIFPHFCLGRGLIDMVRNQAMADAFERLGDKQFQSPLRWDIIGKNLLAMVAQGPLFLLITLLLQHRNRLLPQPKSRLPPPLGEEDEDVVRERERVTKGATQGDVLVLRDLTKVYRGQRSPAVDHLCLGIPPGECFGLLGVNGAGKTSTFRMVTGDTLPSSGEAVLAGHNVAQEPSAAHRSMGYCPQSDAIFDLLTGREHLELFARLRGVPEAQVAQTALSGLVRLGLPSYADRPAGTYSGGNKRKLATALALVGDPAVVFLDEPTTGMDPSARRFLWNNLLSVVREGRSVVLTSHSMEECEALCTRLAIMVNGRFRCLGSAQHLKSRFGAGHTLTLRVPPDQPEPAIAFIVTTFPDAELREVHGSRLRFQLPPGGGCTLARVFRELAAQGKAHGVEDFSVSQTTLEEVFLYFSKDQGEEEEGSGQETETREVSTPGLQHPKRVSRFLEDPSSVETVI
uniprot
proteins
function
FUNCTION: ATP-binding cassette (ABC) transporter that plays a role in lipid homeostasis and macrophage-mediated phagocytosis (By similarity). Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells (By similarity). May also mediate cholesterol efflux (By similarity). May regulate cellular ceramide homeostasis during keratinocyte differentiation (By similarity). Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation (By similarity). Plays a role in phagocytosis of apoptotic cells by macrophages (By similarity). Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7 (By similarity). Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages (By similarity). Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing (By similarity). {ECO:0000250|UniProtKB:Q8IZY2, ECO:0000250|UniProtKB:Q91V24}.
uniprot
proteins
mass_dalton
237720
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q91V24}.
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCA family
uniprot
proteins
pubmed
12727224
uniprot
proteins
sequence_length
2170
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12727224}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:12727224}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:Q91V24}; Multi-pass membrane protein {ECO:0000255}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q91V24}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:Q91V24}. Cytoplasm {ECO:0000250|UniProtKB:Q91V24}. Note=Localizes to cell membrane ruffles and phagocytic cups of macrophages stimulated with C1q or apoptotic cells. Localizes to the cytoplasm of resting macrophages, probably in Golgi and endosomes. Localizes to the apical brush border of cells in the proximal tubules of kidney. {ECO:0000250|UniProtKB:Q91V24}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 548..568; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 591..611; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 624..644; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 653..673; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 679..699; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 733..753; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 847..867; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1257..1277; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1563..1583; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1609..1629; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1646..1666; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1674..1694; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1708..1728; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1754..1774; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins