P23441
uniprot
P23441
canonical
amino_acid_sequence
MSMSPKHTTPFSVSDILSPLEESYKKVGMEGGGLGAPLAAYRQGQAAPPAAAMQQHAVGHHGAVTAAYHMTAAGVPQLSHSAVGGYCNGNLGNMSELPPYQDTMRNSASGPGWYGANPDPRFPAISRFMGPASGMNMSGMGGLGSLGDVSKNMAPLPSAPRRKRRVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKDKAAQQQLQQDSGGGGGGGGGAGCPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAASLQGHAQQQAQQQAQAAQAAAAAISVGSGGAGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQVSSLSHLNSSGSDYGAMSCSTLLYGRTW
uniprot
proteins
function
FUNCTION: Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation (By similarity). Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1 (PubMed:22356123). {ECO:0000250|UniProtKB:P50220, ECO:0000269|PubMed:22356123}.
uniprot
proteins
mass_dalton
38554
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine residues by STK3/MST2. {ECO:0000269|PubMed:9430685}.
uniprot
proteins
protein_family
NK-2 homeobox family
uniprot
proteins
pubmed
1976511
uniprot
proteins
pubmed
22356123
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7980615
uniprot
proteins
pubmed
8282100
uniprot
proteins
pubmed
8898894
uniprot
proteins
pubmed
9430685
uniprot
proteins
sequence_length
372
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P50220}.
uniprot
proteins