FMO5
entrez
2330
canonical
uniprot
P49326
canonical
ensembl
ENSG00000131781
resolver
ensp
ENSP00000254090
resolver
ensp
ENSP00000358277
resolver
ensp
ENSP00000416011
resolver
ensp
ENSP00000535907
resolver
ensp
ENSP00000535910
resolver
ensp
ENSP00000535911
resolver
ensp
ENSP00000535912
resolver
ensp
ENSP00000535921
resolver
ensp
ENSP00000535924
resolver
ensp
ENSP00000535925
resolver
ensp
ENSP00000780788
resolver
ensp
ENSP00000780789
resolver
ensp
ENSP00000780793
resolver
genesymbol
FMO5
resolver
hgnc
HGNC:3773
resolver
uniprot
B2RBG1
resolver
uniprot
C9JJD1
resolver
uniprot
Q8IV22
resolver
uniprot_entry
FMO5_HUMAN
resolver
uniprot_sec
B2RBG1
resolver
uniprot_sec
C9JJD1
resolver
uniprot_sec
Q8IV22
resolver
amino_acid_sequence
MTKKRIAVIGGGVSGLSSIKCCVEEGLEPVCFERTDDIGGLWRFQENPEEGRASIYKSVIINTSKEMMCFSDYPIPDHYPNFMHNAQVLEYFRMYAKEFDLLKYIRFKTTVCSVKKQPDFATSGQWEVVTESEGKKEMNVFDGVMVCTGHHTNAHLPLESFPGIEKFKGQYFHSRDYKNPEGFTGKRVIIIGIGNSGGDLAVEISQTAKQVFLSTRRGAWILNRVGDYGYPADVLFSSRLTHFIWKICGQSLANKYLEKKINQRFDHEMFGLKPKHRALSQHPTLNDDLPNRIISGLVKVKGNVKEFTETAAIFEDGSREDDIDAVIFATGYSFDFPFLEDSVKVVKNKISLYKKVFPPNLERPTLAIIGLIQPLGAIMPISELQGRWATQVFKGLKTLPSQSEMMAEISKAQEEIDKRYVESQRHTIQGDYIDTMEELADLVGVRPNLLSLAFTDPKLALHLLLGPCTPIHYRVQGPGKWDGARKAILTTDDRIRKPLMTRVVERSSSMTSTMTIGKFMLALAFFAIIIAYF
uniprot
proteins
ec_number
1.14.13.-
uniprot
proteins
ec_number
1.14.13.8
uniprot
proteins
ec_number
1.6.3.1
uniprot
proteins
function
FUNCTION: Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters (PubMed:20947616, PubMed:26771671, PubMed:28783300). Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive (PubMed:26771671, PubMed:7872795). In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms (Probable) (PubMed:7872795). Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline (PubMed:28783300). Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity (PubMed:26771671). Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects (By similarity). {ECO:0000250|UniProtKB:P97872, ECO:0000269|PubMed:20947616, ECO:0000269|PubMed:26771671, ECO:0000269|PubMed:28783300, ECO:0000269|PubMed:7872795, ECO:0000305|PubMed:26771671}.
uniprot
proteins
mass_dalton
60221
uniprot
proteins
protein_family
FMO family
uniprot
proteins
pubmed
12527699
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
20947616
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26771671
uniprot
proteins
pubmed
28783300
uniprot
proteins
pubmed
7872795
uniprot
proteins
sequence_length
533
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000305|PubMed:20947616}. Endoplasmic reticulum membrane.
uniprot
proteins
transmembrane_region
TRANSMEM 513..533; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins