AWAT2
entrez
158835
canonical
uniprot
Q6E213
canonical
ensembl
ENSG00000147160
resolver
ensp
ENSP00000421172
resolver
ensp
ENSP00000619886
resolver
enst
ENST00000276101
resolver
enst
ENST00000949827
resolver
genesymbol
AWAT2
resolver
genesymbol_syn
DC4
resolver
genesymbol_syn
DGAT2L4
resolver
genesymbol_syn
MFAT
resolver
genesymbol_syn
WS
resolver
hgnc
HGNC:23251
resolver
uniprot
Q6IEE3
resolver
uniprot
Q6P437
resolver
uniprot_entry
AWAT2_HUMAN
resolver
uniprot_sec
Q6IEE3
resolver
uniprot_sec
Q6P437
resolver
activity_regulation
ACTIVITY REGULATION: 11-cis retinoids act as allosteric modulators of acyl-CoA retinol O-fatty-acyltransferase (ARAT) activity by suppressing esterification of 9-cis, 13-cis, or all-trans retinols concurrently increasing the enzyme specificity toward 11-cis isomer. {ECO:0000250|UniProtKB:Q6E1M8}.
uniprot
proteins
amino_acid_sequence
MLLPSKKDLKTALDVFAVFQWSFSALLITTTVIAVNLYLVVFTPYWPVTVLILTWLAFDWKTPQRGGRRFTCVRHWRLWKHYSDYFPLKLLKTHDICPSRNYILVCHPHGLFAHGWFGHFATEASGFSKIFPGITPYILTLGAFFWMPFLREYVMSTGACSVSRSSIDFLLTHKGTGNMVIVVIGGLAECRYSLPGSSTLVLKNRSGFVRMALQHGVPLIPAYAFGETDLYDQHIFTPGGFVNRFQKWFQSMVHIYPCAFYGRGFTKNSWGLLPYSRPVTTIVGEPLPMPKIENPSQEIVAKYHTLYIDALRKLFDQHKTKFGISETQELEII
uniprot
proteins
ec_number
2.3.1.20
uniprot
proteins
ec_number
2.3.1.75
uniprot
proteins
ec_number
2.3.1.76
uniprot
proteins
function
FUNCTION: Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters (PubMed:15220349, PubMed:15671038, PubMed:16106050, PubMed:28420705). Shows a preference for medium chain acyl-CoAs from C12 to C16 in length and fatty alcohols shorter than C20, as the acyl donors and acceptors, respectively (PubMed:15220349, PubMed:15671038). Also possesses acyl-CoA retinol acyltransferase (ARAT) activity that preferentially esterifies 11-cis-retinol, a chromophore precursor of bleached opsin pigments in cone cells (PubMed:16106050, PubMed:24799687). Shows higher catalytic efficiency toward 11-cis-retinol versus 9-cis-retinol, 13-cis-retinol, and all-trans-retinol substrates (PubMed:24799687). {ECO:0000269|PubMed:15220349, ECO:0000269|PubMed:15671038, ECO:0000269|PubMed:16106050, ECO:0000269|PubMed:24799687, ECO:0000269|PubMed:28420705}.
uniprot
proteins
mass_dalton
38094
uniprot
proteins
protein_family
Diacylglycerol acyltransferase family
uniprot
proteins
pubmed
14970677
uniprot
proteins
pubmed
15220349
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15671038
uniprot
proteins
pubmed
16106050
uniprot
proteins
pubmed
24799687
uniprot
proteins
pubmed
28420705
uniprot
proteins
sequence_length
333
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6E1M8}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..35; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 38..58; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 130..150; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins