Klkb1
entrez
16621
canonical
uniprot
P26262
canonical
ensembl
ENSMUSG00000109764
resolver
ensp
ENSMUSP00000026907
resolver
enst
ENSMUST00000026907
resolver
genesymbol
Klkb1
resolver
genesymbol_syn
Klk3
resolver
genesymbol_syn
Pk
resolver
uniprot
Q8R0P5
resolver
uniprot_entry
KLKB1_MOUSE
resolver
uniprot_sec
Q8R0P5
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by SERPINA5. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MILFNRVGYFVSLFATVSCGCMTQLYKNTFFRGGDLAAIYTPDAQYCQKMCTFHPRCLLFSFLAVTPPKETNKRFGCFMKESITGTLPRIHRTGAISGHSLKQCGHQISACHRDIYKGLDMRGSNFNISKTDNIEECQKLCTNNFHCQFFTYATSAFYRPEYRKKCLLKHSASGTPTSIKSADNLVSGFSLKSCALSEIGCPMDIFQHSAFADLNVSQVITPDAFVCRTICTFHPNCLFFTFYTNEWETESQRNVCFLKTSKSGRPSPPIPQENAISGYSLLTCRKTRPEPCHSKIYSGVDFEGEELNVTFVQGADVCQETCTKTIRCQFFIYSLLPQDCKEEGCKCSLRLSTDGSPTRITYGMQGSSGYSLRLCKLVDSPDCTTKINARIVGGTNASLGEWPWQVSLQVKLVSQTHLCGGSIIGRQWVLTAAHCFDGIPYPDVWRIYGGILSLSEITKETPSSRIKELIIHQEYKVSEGNYDIALIKLQTPLNYTEFQKPICLPSKADTNTIYTNCWVTGWGYTKEQGETQNILQKATIPLVPNEECQKKYRDYVINKQMICAGYKEGGTDACKGDSGGPLVCKHSGRWQLVGITSWGEGCARKDQPGVYTKVSEYMDWILEKTQSSDVRALETSSA
uniprot
proteins
ec_number
3.4.21.34
uniprot
proteins
function
FUNCTION: The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
uniprot
proteins
mass_dalton
71383
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
protein_family
Plasma kallikrein subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16944957
uniprot
proteins
pubmed
17330941
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2264928
uniprot
proteins
sequence_length
638
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins