Plxnd1
entrez
67784
canonical
uniprot
Q3UH93
canonical
ensembl
ENSMUSG00000030123
resolver
ensp
ENSMUSP00000015511
resolver
enst
ENSMUST00000015511
resolver
genesymbol
Plxnd1
resolver
uniprot
Q68HV1
resolver
uniprot_entry
PLXD1_MOUSE
resolver
uniprot_sec
Q68HV1
resolver
amino_acid_sequence
MARRAAGGAPPSARAAAAVPLRPRPHSRGPGLLPLPLLLLLGAARAGALEIQRRFPSPTPTNNFALDGTAGTVYLAAVNRLYQLSSANLSLEAEATVGPVPDSPLCHAPQLPQASCEHPRRLTDNYNKILQLDPGQGLVVACGSIYQGLCQLRRRGNISALAVSFPPAAPTAEPVTVFPSMLNVAANHPNASTVGLVLPPTSGTGGSRLLVGATYTGFGSAFFPRNRSLEDHRFENTPEIAIRSLDARGDLAKLFTFDLNPSDDNILKIKQGAKEQHKLGFVRAFLHPAVPPHSAQPYAYLALNSEARAGDKDSQARSLLARICLPRGAGGDAKKLTESYIQLGLQCAGGAGRGDLYSRLVSVFPAREQFFAVFERPQGAPGARNAPAALCAFRFDDVQAAIRAARTACFVEPAPDVVAVLDSVVQGTGPACESKRNIQLQPEQLDCGAAHLQHPLTILQPLRASPVFRAPGLTAVAVASANNYTAVFLGTATGRLLKISLNESMQVVSRRVLTVAYGEPVHHVMQFDPMDPGYLYLMTSHQMARVKVAACEVHSTCGDCVGAADAYCGWCTLETRCTLQQDCTNSSQPHFWTSASEGPSRCPAMTVLPSEIDVHRDYTGMILQISGSLPSLSGMEMACDYGNGVRTVARVPGPAYDHQIAYCNLLPRAQFPSFPAGQDHVTVEMSVRVKGHNIVSANFTIYDCSRIGQVYPHTACTSCLSTQWPCSWCIQLHSCVSNQSQCQDSPNPTSPQDCPQILPSPLAPVPTGGSQDILVPLTKATFFHGSSLECSFGLEESFEAVWANNSLVRCNQVVLHTTQKSQVFPLSLKLKGPPDRFLDSPNPMTVVVYNCAMGSPDCSQCLGREDLGHLCVWNDGCRLRGPLQPLPGTCPAPEIRAIEPLSGPLDGGTLLTIRGRNLGRRLSDVAHGVWIGSVACEPLADRYTVSEEIVCATGPAAGAFSDVVTVNVSKEGRSREQFSYVLPTVHSLEPSMGPKAGGTRITIHGSDLNVGSMLQVLVNDTDPCTDLTRTATSITCTVPGGTLPSPVPVCVRFESRGCVHGNLTFWYMQNPVITAISPGRSPVSGGRTITVAGERFHMVQNVSMAVHHIGREPTFCKVLNSTLITCPSPGALSNASAPVDFFINGRAYADEAAEELLDPAEAQRGSRFRLDYLPNPQFSTAKREKWIKHHPGEPLTLVIHKEQDSLGLESHEYHIKIGQVSCDIQIISDRVIHCSVNESLGTAEGQLPITIQVGNFNQTIATLQLGGSETAIVVSIVICSVLLLLSVVALFVFCTKSRRAERYWQKTLLQMEEMESQIREEIRKGFAELQTDMTDLTKELNRSQGIPFLEYKHFVTRTFFPKCSSLYEERYVLPSKTLNSQGGSPPQETHPLLGEWNIPEHCRPSMEEGISLFSSLLNNKHFLIVFVHALEQQKDFAVRDRCSLASLLTIALHGKLEYYTSIMKELLVDLIDASAAKNPKLMLRRTESVVEKMLTNWMSICMYGCLRETVGEPFFLLLCAIKQQINKGSIDAITGKARYTLNEEWLLRENIEAKPRNLNVSFQGCGMDSLSVRAMDTDTLTQVKEKILEAFCKNVPYSQWPRAEDVDLEWFASSTQSYVLRDLDDTSVVEDGRKKLNTLAHYKIPEGASLAMSLTDKKDSTLGRVKDLDTEKYFHLVLPTDELVEPKKSHRQSHRKKVLPEIYLTRLLSTKGTLQKFLDDLFKAILSIREDKPPLAVKYFFDFLEEQAEKRGISDPDTLHIWKTNSLPLRFWVNILKNPQFVFDIEKTDHIDACLSVIAQAFIDACSISDLQLGKDSPTNKLLYAKEIPEYRKTVQRYYKQIQDMTPLSEQEMNAHLAEESRKYQNEFNTNVAMAEIYKYAKRYRPQIMAALEANPTARRTQLQHKFEQVVALMENNIYECYSEA
uniprot
proteins
function
FUNCTION: Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E. Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types. Regulates the migration of thymocytes in the medulla. Regulates endothelial cell migration. Plays an important role in ensuring the specificity of synapse formation. Mediates anti-angiogenic signaling in response to SEMA3E. Required for normal development of the heart and vasculature. {ECO:0000269|PubMed:15239958, ECO:0000269|PubMed:17318185, ECO:0000269|PubMed:18992737, ECO:0000269|PubMed:19027330, ECO:0000269|PubMed:19421194, ECO:0000269|PubMed:22179111}.
uniprot
proteins
mass_dalton
211608
uniprot
proteins
protein_family
Plexin family
uniprot
proteins
pubmed
15239958
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17318185
uniprot
proteins
pubmed
18992737
uniprot
proteins
pubmed
19027330
uniprot
proteins
pubmed
19421194
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22179111
uniprot
proteins
sequence_length
1925
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17318185, ECO:0000269|PubMed:19027330}; Single-pass membrane protein {ECO:0000269|PubMed:17318185, ECO:0000269|PubMed:19027330}. Cell projection, lamellipodium membrane {ECO:0000250|UniProtKB:Q9Y4D7}.
uniprot
proteins
transmembrane_region
TRANSMEM 1272..1292; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins