Izumo1r
entrez
64931
canonical
uniprot
Q9EQF4
canonical
ensembl
ENSMUSG00000031933
resolver
ensp
ENSMUSP00000034409
resolver
ensp
ENSMUSP00000063632
resolver
ensp
ENSMUSP00000113459
resolver
ensp
ENSMUSP00000263477
resolver
ensp
ENSMUSP00000364243
resolver
enst
ENSMUST00000069408
resolver
genesymbol
Izumo1r
resolver
genesymbol_syn
Folbp3
resolver
genesymbol_syn
Folr4
resolver
genesymbol_syn
Juno
resolver
uniprot
B0FFS5
resolver
uniprot
F6TEH5
resolver
uniprot
Q8BUM2
resolver
uniprot
Q8BY83
resolver
uniprot_entry
F6TEH5_MOUSE
resolver
uniprot_entry
JUNO_MOUSE
resolver
uniprot_entry
Q8BUM2_MOUSE
resolver
uniprot_entry
Q8BY83_MOUSE
resolver
uniprot_sec
B0FFS5
resolver
amino_acid_sequence
MAQWWQILLGLWAVLPTLAGDKLLSVCMNSKRHKQEPGPEDELYQECRPWEDNACCTRSTSWEAHLEEPLLFNFSMMHCGLLTPACRKHFIQAICFHECSPNLGPWIQPVVPNGQEEQRVWGVPLCQEDCEDWWRACHSSLTCKSNWLHGWDWSEEKKHCPAHEPCLPFSYHFPTPDDLCEKIWNNTFKASPERRNSGRCLQKWFEPTLSNPNVEVALHFAGSALAPQLSYTLPAFSLCLLFHP
uniprot
proteins
function
FUNCTION: Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization (PubMed:24739963, PubMed:26859261, PubMed:27309808, PubMed:27416963). The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion (PubMed:24739963, PubMed:26859261, PubMed:27309808). The ligand-receptor interaction probably does not act as a membrane 'fusogen' (PubMed:24739963, PubMed:26859261, PubMed:27309808). Does not bind folate (PubMed:24739963). {ECO:0000269|PubMed:24739963, ECO:0000269|PubMed:26859261, ECO:0000269|PubMed:27309808, ECO:0000269|PubMed:27416963}.
uniprot
proteins
mass_dalton
28203
uniprot
proteins
mutagenesis
MUTAGEN 62; /note="W->A: Impaired ability to promote sperm-egg interaction due to reduced interaction with IZUMO1."; /evidence="ECO:0000269|PubMed:27416963"; MUTAGEN 66; /note="L->A: Does not affect ability to promote sperm-egg interaction."; /evidence="ECO:0000269|PubMed:27416963"; MUTAGEN 73; /note="N->D: Does not affect ability to promote sperm-egg interaction."; /evidence="ECO:0000269|PubMed:27416963"; MUTAGEN 73; /note="N->Q: Reduces apparent molecular weight of the protein, in agreement with the loss of one glycosylation site. Abolishes secretion of the extracellular domain; when associated with G-185."; /evidence="ECO:0000269|PubMed:26859261"; MUTAGEN 97; /note="H->A: Does not affect ability to promote sperm-egg interaction."; /evidence="ECO:0000269|PubMed:27416963"; MUTAGEN 184; /note="W->A: Does not affect ability to promote sperm-egg interaction."; /evidence="ECO:0000269|PubMed:27416963"; MUTAGEN 185; /note="N->D: Reduced stability of the protein."; /evidence="ECO:0000269|PubMed:27416963"; MUTAGEN 185; /note="N->G: Reduces apparent molecular weight of the protein, in agreement with the loss of one glycosylation site. Abolishes secretion of the extracellular domain; when associated with Q-73."; /evidence="ECO:0000269|PubMed:26859261"; MUTAGEN 185; /note="N->S: No effect on interaction with IZUMO1."; /evidence="ECO:0000269|PubMed:26859261
uniprot
proteins
post_translational_modification
PTM: The protein is rapidly cleaved following fertilization, being only weakly detectable in zona-intact fertilized eggs at telophase II and undetectable at the pronuclear stage (PubMed:24739963). Sheding is probably required to block to polyspermy and ensuring egg fusion with a single sperm (PubMed:24739963). {ECO:0000269|PubMed:24739963}.
uniprot
proteins
protein_family
Folate receptor family
uniprot
proteins
pubmed
11111049
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24739963
uniprot
proteins
pubmed
25209248
uniprot
proteins
pubmed
26859261
uniprot
proteins
pubmed
27309808
uniprot
proteins
pubmed
27416963
uniprot
proteins
pubmed
32484434
uniprot
proteins
pubmed
36394541
uniprot
proteins
sequence_length
244
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24739963, ECO:0000269|PubMed:25209248, ECO:0000269|PubMed:27309808}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:24739963}. Note=GPI-anchored at the oolemma. {ECO:0000269|PubMed:24739963}.
uniprot
proteins