OR6A2
entrez
8590
canonical
uniprot
O95222
canonical
ensembl
ENSG00000184933
resolver
ensp
ENSP00000492990
resolver
enst
ENST00000641196
resolver
genesymbol
OR6A2
resolver
genesymbol_syn
OR6A1
resolver
genesymbol_syn
OR6A2P
resolver
hgnc
HGNC:15301
resolver
uniprot
Q3MJC7
resolver
uniprot
Q6IF35
resolver
uniprot
Q9H206
resolver
uniprot_entry
OR6A2_HUMAN
resolver
uniprot_sec
Q3MJC7
resolver
uniprot_sec
Q6IF35
resolver
uniprot_sec
Q9H206
resolver
amino_acid_sequence
MEWRNHSGRVSEFVLLGFPAPAPLQVLLFALLLLAYVLVLTENTLIIMAIRNHSTLHKPMYFFLANMSFLEIWYVTVTIPKMLAGFVGSKQDHGQLISFEGCMTQLYFFLGLGCTECVLLAVMAYDRYMAICYPLHYPVIVSGRLCVQMAAGSWAGGFGISMVKVFLISGLSYCGPNIINHFFCDVSPLLNLSCTDMSTAELTDFILAIFILLGPLSVTGASYVAITGAVMHIPSAAGRYKAFSTCASHLTVVIIFYAASIFIYARPKALSAFDTNKLVSVLYAVIVPLLNPIIYCLRNQEVKRALCCTLHLYQHQDPDPKKASRNV
uniprot
proteins
function
FUNCTION: Odorant receptor for medium-chain aliphatic aldehydes, such as octanal, nonanal and trans-2-decenal (PubMed:41570822). Activated by aliphatic aldehydes with chains ranging from 5 to 11 carbon atoms, with preference for octanal (C8) (PubMed:41570822). Ligand-binding involves the formation of a reversible covalent Schiff base linkage with the aldehyde, causing a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL/G(olf) or GNAS/G(s)) (PubMed:41570822). In olfactory epithelium, couples to GNAL/G(olf), mediating activation of adenylate cyclase activity and increased production of cAMP, initiating a neuronal response that triggers the perception of a smell (PubMed:41570822). Beyond its role in olfaction, also acts as a regulator of inflammation (PubMed:35025664). In macrophages, activation by octanal, a product of lipid peroxidation during oxidative stress, triggers a signaling that promotes activation of the NLRP3 inflammasome, leading to the production of pro-inflammatory cytokines, such as IL1B, exacerbating inflammatory processes in vascular macrophages and contributing to atherosclerosis (PubMed:35025664). Outside of the olfactory system, in tissues lacking GNAL/G(olf), couples to GNAS/G(s), promoting activation of adenylate cyclase activity and production of cAMP (PubMed:41570822). {ECO:0000269|PubMed:35025664, ECO:0000269|PubMed:41570822}.
uniprot
proteins
mass_dalton
36154
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11416212
uniprot
proteins
pubmed
14983052
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
35025664
uniprot
proteins
pubmed
41570822
uniprot
proteins
pubmed
9787077
uniprot
proteins
sequence_length
327
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:41570822}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 27..47; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 56..76; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 105..125; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 145..165; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 202..222; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 243..263; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 277..297; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins