AKR7A2
entrez
8574
canonical
uniprot
O43488
canonical
ensembl
ENSG00000053371
resolver
ensp
ENSP00000235835
resolver
ensp
ENSP00000339084
resolver
ensp
ENSP00000703772
resolver
enst
ENST00000235835
resolver
enst
ENST00000330072
resolver
genesymbol
AKR7A2
resolver
genesymbol
HEL-S-166mP
resolver
genesymbol_syn
AFAR
resolver
genesymbol_syn
AFAR1
resolver
genesymbol_syn
AKR7
resolver
genesymbol_syn
AKR7A2
resolver
hgnc
HGNC:389
resolver
uniprot
B4DZX4
resolver
uniprot
H3BLU7
resolver
uniprot
O75749
resolver
uniprot
Q5TG63
resolver
uniprot
V9HWA2
resolver
uniprot_entry
ARK72_HUMAN
resolver
uniprot_entry
B4DZX4_HUMAN
resolver
uniprot_entry
H3BLU7_HUMAN
resolver
uniprot_entry
V9HWA2_HUMAN
resolver
uniprot_sec
O75749
resolver
uniprot_sec
Q5TG63
resolver
amino_acid_sequence
MLSAASRVVSRAAVHCALRSPPPEARALAMSRPPPPRVASVLGTMEMGRRMDAPASAAAVRAFLERGHTELDTAFMYSDGQSETILGGLGLGLGGGDCRVKIATKANPWDGKSLKPDSVRSQLETSLKRLQCPQVDLFYLHAPDHGTPVEETLHACQRLHQEGKFVELGLSNYASWEVAEICTLCKSNGWILPTVYQGMYNATTRQVETELFPCLRHFGLRFYAYNPLAGGLLTGKYKYEDKDGKQPVGRFFGNSWAETYRNRFWKEHHFEAIALVEKALQAAYGASAPSVTSAALRWMYHHSQLQGAHGDAVILGMSSLEQLEQNLAATEEGPLEPAVVDAFNQAWHLVAHECPNYFR
uniprot
proteins
ec_number
1.1.1.n11
uniprot
proteins
function
FUNCTION: Catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate. May have an important role in producing the neuromodulator gamma-hydroxybutyrate (GHB). Has broad substrate specificity. Has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). Can reduce 1,2-naphthoquinone and 9,10-phenanthrenequinone (in vitro). Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. {ECO:0000269|PubMed:17591773, ECO:0000269|PubMed:9576847}.
uniprot
proteins
mass_dalton
39589
uniprot
proteins
protein_family
Aldo/keto reductase 2 subfamily
uniprot
proteins
protein_family
Aldo/keto reductase family
uniprot
proteins
pubmed
10510318
uniprot
proteins
pubmed
12071861
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17591773
uniprot
proteins
pubmed
18752886
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
9576847
uniprot
proteins
pubmed
9823300
uniprot
proteins
sequence_length
359
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255}. Golgi apparatus {ECO:0000250|UniProtKB:Q8CG45}. Cytoplasm {ECO:0000269|PubMed:9576847}.
uniprot
proteins