Il23a
entrez
155140
canonical
uniprot
Q91Z84
canonical
ensembl
ENSRNOG00000003254
resolver
ensembl
ENSRNOG00055013661
resolver
ensembl
ENSRNOG00060024397
resolver
ensembl
ENSRNOG00065013455
resolver
ensp
ENSRNOP00000004363
resolver
ensp
ENSRNOP00055019065
resolver
ensp
ENSRNOP00060035039
resolver
ensp
ENSRNOP00065017159
resolver
enst
ENSRNOT00000004363
resolver
enst
ENSRNOT00055023453
resolver
enst
ENSRNOT00060042256
resolver
enst
ENSRNOT00065022129
resolver
genesymbol
Il23a
resolver
uniprot_entry
IL23A_RAT
resolver
amino_acid_sequence
MLDCRAIILLWLLPWATQGLAVPRSSSPDWAQCQQLSRNLCTLAWSAHTPVGQMDLLREEGEEETKSDVPRIQCGDGCDPQGLKDNSQFCLQRIRQGLVFYKHLLDSDIFTGEPSLLPDSPVDQLHTSLLGLSQLLQPEDHHWETQQMPRLSPSQQWQRSLLRSKILRSLQAFLAIAARVFAHGAATLTEPLVPTA
uniprot
proteins
function
FUNCTION: Associates with IL12B to form the pro-inflammatory cytokine IL-23 that plays different roles in innate and adaptive immunity. Released by antigen-presenting cells such as dendritic cells or macrophages, binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R to activate JAK2 and TYK2 which then phosphorylate the receptor to form a docking site leading to the phosphorylation of STAT3 and STAT4. This process leads to activation of several pathways including p38 MAPK or NF-kappa-B and promotes the production of pro-inflammatory cytokines such as interleukin-17A/IL17A. In turn, participates in the early and effective intracellular bacterial clearance. Promotes the expansion and survival of T-helper 17 cells, a CD4-positive helper T-cell subset that produces IL-17, as well as other IL-17-producing cells. {ECO:0000250|UniProtKB:Q9NPF7}.
uniprot
proteins
mass_dalton
21986
uniprot
proteins
protein_family
IL-6 superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
196
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Secreted upon association with IL12B. {ECO:0000250}.
uniprot
proteins