NCOA4
entrez
8031
canonical
uniprot
Q13772
canonical
ensembl
ENSG00000266412
resolver
ensp
ENSP00000462943
resolver
ensp
ENSP00000463027
resolver
ensp
ENSP00000463455
resolver
ensp
ENSP00000463476
resolver
ensp
ENSP00000464054
resolver
genesymbol
NCOA4
resolver
genesymbol_syn
ARA70
resolver
genesymbol_syn
ELE1
resolver
genesymbol_syn
RFG
resolver
hgnc
HGNC:7671
resolver
uniprot
A8K8W5
resolver
uniprot
B2R5V0
resolver
uniprot
B4E260
resolver
uniprot
E9PAV7
resolver
uniprot
J3KQN8
resolver
uniprot
Q14239
resolver
uniprot
Q96E88
resolver
uniprot_entry
B2R5V0_HUMAN
resolver
uniprot_entry
NCOA4_HUMAN
resolver
uniprot_entry
Q96E88_HUMAN
resolver
uniprot_sec
A8K8W5
resolver
uniprot_sec
B4E260
resolver
uniprot_sec
E9PAV7
resolver
uniprot_sec
J3KQN8
resolver
uniprot_sec
Q14239
resolver
amino_acid_sequence
MNTFQDQSGSSSNREPLLRCSDARRDLELAIGGVLRAEQQIKDNLREVKAQIHSCISRHLECLRSREVWLYEQVDLIYQLKEETLQQQAQQLYSLLGQFNCLTHQLECTQNKDLANQVSVCLERLGSLTLKPEDSTVLLFEADTITLRQTITTFGSLKTIQIPEHLMAHASSANIGPFLEKRGCISMPEQKSASGIVAVPFSEWLLGSKPASGYQAPYIPSTDPQDWLTQKQTLENSQTSSRACNFFNNVGGNLKGLENWLLKSEKSSYQKCNSHSTTSSFSIEMEKVGDQELPDQDEMDLSDWLVTPQESHKLRKPENGSRETSEKFKLLFQSYNVNDWLVKTDSCTNCQGNQPKGVEIENLGNLKCLNDHLEAKKPLSTPSMVTEDWLVQNHQDPCKVEEVCRANEPCTSFAECVCDENCEKEALYKWLLKKEGKDKNGMPVEPKPEPEKHKDSLNMWLCPRKEVIEQTKAPKAMTPSRIADSFQVIKNSPLSEWLIRPPYKEGSPKEVPGTEDRAGKQKFKSPMNTSWCSFNTADWVLPGKKMGNLSQLSSGEDKWLLRKKAQEVLLNSPLQEEHNFPPDHYGLPAVCDLFACMQLKVDKEKWLYRTPLQM
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving NCOA4 is found in papillary thyroid carcinomas (PTCs). Inversion inv(10)(q11.2;q11.2) generates the RET/NCOA4 (PTC3) oncogene. {ECO:0000269|PubMed:8187085, ECO:0000269|PubMed:8290261}.
uniprot
proteins
function
FUNCTION: Cargo receptor for the autophagic turnover of the iron-binding ferritin complex, playing a central role in iron homeostasis (PubMed:25327288, PubMed:26436293). Acts as an adapter for delivery of ferritin to lysosomes and autophagic degradation of ferritin, a process named ferritinophagy (PubMed:25327288, PubMed:26436293). Targets the iron-binding ferritin complex to autolysosomes following starvation or iron depletion (PubMed:25327288). Ensures efficient erythropoiesis, possibly by regulating hemin-induced erythroid differentiation (PubMed:26436293). In some studies, has been shown to enhance the androgen receptor AR transcriptional activity as well as acting as ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma (PubMed:10347167, PubMed:8643607). Another study shows only weak behavior as a coactivator for the androgen receptor and no alteration of the ligand responsiveness of the AR (PubMed:10517667). Binds to DNA replication origins, binding is not restricted to sites of active transcription and may likely be independent from the nuclear receptor transcriptional coactivator function (PubMed:24910095). May inhibit activation of DNA replication origins, possibly by obstructing DNA unwinding via interaction with the MCM2-7 complex (PubMed:24910095). {ECO:0000269|PubMed:10347167, ECO:0000269|PubMed:10517667, ECO:0000269|PubMed:24910095, ECO:0000269|PubMed:25327288, ECO:0000269|PubMed:26436293, ECO:0000269|PubMed:8643607}.
uniprot
proteins
mass_dalton
69726
uniprot
proteins
mutagenesis
MUTAGEN 95..96; /note="LL->AA: Decreased interaction with PPAR and RXR. No impact on interaction with MCM7. No impact on binding to DNA replication origins."; /evidence="ECO:0000269|PubMed:10347167, ECO:0000269|PubMed:24910095"; MUTAGEN 489..497; /note="IKNSPLSEW->AKNSPLSEA: Abrogates interaction with ferritin heavy chain FTH1. Attenuates FTH1 localization to lysosomes following iron chelation."; /evidence="ECO:0000269|PubMed:26436293
uniprot
proteins
post_translational_modification
PTM: NCOA4 levels are regulated via HERC2-mediated ubiquitination leading to proteosomal degradation; HERC2 association is dependent on NCOA4 [2Fe-2S] cluster-binding. {ECO:0000269|PubMed:25327288}.
uniprot
proteins
pubmed
10347167
uniprot
proteins
pubmed
10517667
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15563469
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
24910095
uniprot
proteins
pubmed
25327288
uniprot
proteins
pubmed
26436293
uniprot
proteins
pubmed
8187085
uniprot
proteins
pubmed
8290261
uniprot
proteins
pubmed
8643607
uniprot
proteins
pubmed
9892017
uniprot
proteins
sequence_length
614
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:25327288}. Autolysosome {ECO:0000269|PubMed:25327288}. Nucleus {ECO:0000269|PubMed:24910095}. Chromosome {ECO:0000269|PubMed:24910095}.
uniprot
proteins