Gpx4
entrez
29328
canonical
uniprot
P36970
canonical
ensembl
ENSRNOG00000013604
resolver
ensembl
ENSRNOG00055032495
resolver
ensembl
ENSRNOG00060031990
resolver
ensembl
ENSRNOG00065019685
resolver
ensp
ENSRNOP00000076198
resolver
genesymbol
Gpx4
resolver
uniprot
Q6PZ55
resolver
uniprot
Q76LU9
resolver
uniprot
Q91XR8
resolver
uniprot_entry
GPX4_RAT
resolver
uniprot_sec
Q6PZ55
resolver
uniprot_sec
Q76LU9
resolver
uniprot_sec
Q91XR8
resolver
amino_acid_sequence
MSWGRLSRLLKPALLCGALAVPGLAGTMCASRDDWRCARSMHEFAAKDIDGHMVCLDKYRGCVCIVTNVASQUGKTDVNYTQLVDLHARYAECGLRILAFPCNQFGRQEPGSNQEIKEFAAGYNVRFDMYSKICVNGDDAHPLWKWMKVQPKGRGMLGNAIKWNFTKFLIDKNGCVVKRYGPMEEPQVIEKDLPCYL
uniprot
proteins
ec_number
1.11.1.12
uniprot
proteins
ec_number
1.11.1.9
uniprot
proteins
function
FUNCTION: Essential antioxidant peroxidase that directly reduces phospholipid hydroperoxide even if they are incorporated in membranes and lipoproteins (By similarity). Can also reduce fatty acid hydroperoxide, cholesterol hydroperoxide and thymine hydroperoxide (By similarity). Plays a key role in protecting cells from oxidative damage by preventing membrane lipid peroxidation (PubMed:1556123, PubMed:9988735). Required to prevent cells from ferroptosis, a non-apoptotic cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species (By similarity). The presence of selenocysteine (Sec) versus Cys at the active site is essential for life: it provides resistance to overoxidation and prevents cells against ferroptosis (By similarity). The presence of Sec at the active site is also essential for the survival of a specific type of parvalbumin-positive interneurons, thereby preventing against fatal epileptic seizures (By similarity). May be required to protect cells from the toxicity of ingested lipid hydroperoxides (By similarity). Required for normal sperm development and male fertility (By similarity). Essential for maturation and survival of photoreceptor cells (By similarity). Plays a role in a primary T-cell response to viral and parasitic infection by protecting T-cells from ferroptosis and by supporting T-cell expansion (By similarity). Plays a role of glutathione peroxidase in platelets in the arachidonic acid metabolism (By similarity). Reduces hydroperoxy ester lipids formed by a 15-lipoxygenase that may play a role as down-regulator of the cellular 15-lipoxygenase pathway (By similarity). Can also reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide (By similarity). {ECO:0000250|UniProtKB:O70325, ECO:0000250|UniProtKB:P36968, ECO:0000250|UniProtKB:P36969, ECO:0000269|PubMed:1556123, ECO:0000269|PubMed:9988735}.; FUNCTION: [Isoform Cytoplasmic]: Specifically able to suppress the production of leukotriene and prostaglandin in response to several stimuli by reducing fatty acid hydroperoxide (PubMed:11010961, PubMed:9442035). {ECO:0000269|PubMed:11010961, ECO:0000269|PubMed:9442035}.; FUNCTION: [Isoform Mitochondrial]: Specifically required to prevent mitochondrial cell death by mediating reduction of cardiolipin hydroperoxide (PubMed:10506188, PubMed:10998361, PubMed:9988735). Also required for normal sperm development and male fertility (By similarity). {ECO:0000250|UniProtKB:O70325, ECO:0000269|PubMed:10506188, ECO:0000269|PubMed:10998361, ECO:0000269|PubMed:9988735}.; FUNCTION: [Isoform Nuclear]: Required for male fertility by stabilizing the condensed chromatin in sperm nuclei. {ECO:0000250|UniProtKB:O70325}.
uniprot
proteins
mass_dalton
22225
uniprot
proteins
post_translational_modification
PTM: Degraded via chaperone-mediated autophagy, promoting ferroptosis. {ECO:0000250|UniProtKB:P36969}.; PTM: Hydroxylation by EGLN3/PHD3 promotes its stabilization by preventing degradation via chaperone-mediated autophagy. {ECO:0000250|UniProtKB:P36969}.
uniprot
proteins
protein_family
Glutathione peroxidase family
uniprot
proteins
pubmed
10506188
uniprot
proteins
pubmed
10998361
uniprot
proteins
pubmed
11010961
uniprot
proteins
pubmed
11344099
uniprot
proteins
pubmed
12819198
uniprot
proteins
pubmed
14575705
uniprot
proteins
pubmed
1556123
uniprot
proteins
pubmed
19423663
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7592947
uniprot
proteins
pubmed
8749327
uniprot
proteins
pubmed
9442035
uniprot
proteins
pubmed
9988735
uniprot
proteins
sequence_length
197
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform Nuclear]: Nucleus {ECO:0000269|PubMed:11344099}. Nucleus, nucleolus {ECO:0000269|PubMed:14575705}.; SUBCELLULAR LOCATION: [Isoform Mitochondrial]: Mitochondrion {ECO:0000269|PubMed:1556123}. Cytoplasm {ECO:0000269|PubMed:1556123}.; SUBCELLULAR LOCATION: [Isoform Cytoplasmic]: Cytoplasm {ECO:0000269|PubMed:1556123}.
uniprot
proteins