CYP4A11
entrez
1579
canonical
uniprot
Q02928
canonical
ensembl
ENSG00000187048
resolver
ensp
ENSP00000311095
resolver
ensp
ENSP00000477495
resolver
ensp
ENSP00000579082
resolver
ensp
ENSP00000672902
resolver
enst
ENST00000462347
resolver
genesymbol
CYP4A11
resolver
genesymbol_syn
CYP4A2
resolver
hgnc
HGNC:2642
resolver
uniprot
Q06766
resolver
uniprot
Q16865
resolver
uniprot
Q16866
resolver
uniprot
Q5VSP8
resolver
uniprot
Q86SU6
resolver
uniprot
Q8IWY5
resolver
uniprot
V9GZ77
resolver
uniprot_entry
CP4AB_HUMAN
resolver
uniprot_entry
V9GZ77_HUMAN
resolver
uniprot_sec
Q06766
resolver
uniprot_sec
Q16865
resolver
uniprot_sec
Q16866
resolver
uniprot_sec
Q5VSP8
resolver
uniprot_sec
Q86SU6
resolver
uniprot_sec
Q8IWY5
resolver
activity_regulation
ACTIVITY REGULATION: Activated by cytochrome b5. {ECO:0000269|PubMed:10553002, ECO:0000269|PubMed:7679927}.
uniprot
proteins
amino_acid_sequence
MSVSVLSPSRLLGDVSGILQAASLLILLLLLIKAVQLYLHRQWLLKALQQFPCPPSHWLFGHIQELQQDQELQRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSHGSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIYSLTSAGRWTHRACQLAHQHTDQVIQLRKAQLQKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHSLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPDGRSLPKGIMVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHSHAFLPFSGGSRNCIGKQFAMNELKVATALTLLRFELLPDPTRIPIPIARLVLKSKNGIHLRLRRLPNPCEDKDQL
uniprot
proteins
ec_number
1.14.14.1
uniprot
proteins
ec_number
1.14.14.80
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids and their oxygenated derivatives (oxylipins) (PubMed:10553002, PubMed:10660572, PubMed:15611369, PubMed:1739747, PubMed:7679927, PubMed:8914854). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:10553002, PubMed:10660572, PubMed:15611369, PubMed:1739747, PubMed:7679927, PubMed:8914854). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of saturated and unsaturated fatty acids, the catalytic efficiency decreasing in the following order: dodecanoic > tetradecanoic > (9Z)-octadecenoic > (9Z,12Z)-octadecadienoic > hexadecanoic acid (PubMed:10553002, PubMed:10660572). Acts as a major omega-hydroxylase for dodecanoic (lauric) acid in liver (PubMed:15611369, PubMed:1739747, PubMed:7679927, PubMed:8914854). Participates in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:10620324, PubMed:10660572, PubMed:15611369). Can also catalyze the oxidation of the penultimate carbon (omega-1 oxidation) of fatty acids with lower efficiency (PubMed:7679927). May contribute to the degradation of saturated very long-chain fatty acids (VLCFAs) such as docosanoic acid, by catalyzing successive omega-oxidations to the corresponding dicarboxylic acid, thereby initiating chain shortening (PubMed:18182499). Omega-hydroxylates (9R,10S)-epoxy-octadecanoate stereoisomer (PubMed:15145985). Plays a minor role in omega-oxidation of long-chain 3-hydroxy fatty acids (PubMed:18065749). Has little activity toward prostaglandins A1 and E1 (PubMed:7679927). {ECO:0000269|PubMed:10553002, ECO:0000269|PubMed:10620324, ECO:0000269|PubMed:10660572, ECO:0000269|PubMed:15145985, ECO:0000269|PubMed:15611369, ECO:0000269|PubMed:1739747, ECO:0000269|PubMed:18065749, ECO:0000269|PubMed:18182499, ECO:0000269|PubMed:7679927, ECO:0000269|PubMed:8914854}.
uniprot
proteins
mass_dalton
59348
uniprot
proteins
mutagenesis
MUTAGEN 130; /note="G->S: Loss of activity."; /evidence="ECO:0000269|PubMed:15611369"; MUTAGEN 321; /note="E->A: Loss of covalent heme binding."; /evidence="ECO:0000269|PubMed:11821421
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; arachidonate metabolism. {ECO:0000269|PubMed:15611369}.; PATHWAY: Lipid metabolism; oxylipin biosynthesis. {ECO:0000269|PubMed:10620324, ECO:0000269|PubMed:10660572, ECO:0000269|PubMed:15611369}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
10553002
uniprot
proteins
pubmed
10620324
uniprot
proteins
pubmed
10660572
uniprot
proteins
pubmed
11139583
uniprot
proteins
pubmed
11821421
uniprot
proteins
pubmed
12464262
uniprot
proteins
pubmed
15145985
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15611369
uniprot
proteins
pubmed
15895287
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
1739747
uniprot
proteins
pubmed
18065749
uniprot
proteins
pubmed
18182499
uniprot
proteins
pubmed
7679927
uniprot
proteins
pubmed
7798189
uniprot
proteins
pubmed
8274222
uniprot
proteins
pubmed
8363569
uniprot
proteins
pubmed
8914854
uniprot
proteins
sequence_length
519
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:1739747}; Peripheral membrane protein {ECO:0000305}. Microsome membrane {ECO:0000305|PubMed:1739747}; Peripheral membrane protein {ECO:0000305}.
uniprot
proteins