Smarcad1
entrez
13990
canonical
uniprot
Q04692
canonical
ensembl
ENSMUSG00000029920
resolver
ensp
ENSMUSP00000031984
resolver
ensp
ENSMUSP00000144776
resolver
ensp
ENSMUSP00000145152
resolver
ensp
ENSMUSP00000145340
resolver
ensp
ENSMUSP00000249936
resolver
ensp
ENSMUSP00000249937
resolver
ensp
ENSMUSP00000249942
resolver
ensp
ENSMUSP00000249946
resolver
enst
ENSMUST00000204696
resolver
enst
ENSMUST00000204955
resolver
enst
ENSMUST00000205118
resolver
genesymbol
Smarcad1
resolver
genesymbol_syn
Etl1
resolver
genesymbol_syn
Kiaa1122
resolver
uniprot
A0A0N4SUQ5
resolver
uniprot
Q3UGK6
resolver
uniprot
Q3UYR6
resolver
uniprot_entry
A0A0N4SUQ5_MOUSE
resolver
uniprot_entry
SMRCD_MOUSE
resolver
uniprot_sec
Q3UGK6
resolver
uniprot_sec
Q3UYR6
resolver
amino_acid_sequence
MNLFNLDRFRFEKRSKIEEAPEAAPQPSQARPSSPISLSAEEENAEGEGSRANTPDSDVTEKTEDSSVPEPPDNERKASLSCFQNQRAIQEYIDLSSDTEDVSPNCSSTVQEKKFSKDTVIIVSEPSEDEESHDLPSVTRRNDSSELEDLSELEDLKDAKLQTLKELFPQRSDSDLLKLIESTSTMDGAIAAALLMFGDAGGGPRKRKLSSSSEEDDVNDDQSVKQPRGDRGEESNESAEASSNWEKQESIVLKLQKEFPNFDKQELREVLKEHEWMYTEALESLKVFAEDQDVQCASQSEVTNGKEVARNQNYSKNATKIKMKQKISVKPQNGFNKKRKKNVFNPKKAVEDSEYDSGSDAGSSLDEDYSSCEEVMEDGYKGKILHFLQVSSIAELTLIPKCSQKKAQKITELRPFNNWEALFTKMSKINGLSEDLIWNCKTVIQERDVVIRLMNKCEDISNKLTKQVTMLTGNGGGWNREQPSLLNQSLSLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQEGNKGPHLIVVPASTIDNWLREVNLWCPSLNVLCYYGSQEERKQIRFNIHNKYEDYNVIVTTYNCAISSSDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINARNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTKPADEQSIYEKERIAHAKQIIKPFILRRVKEEVLKLLPPKKDRIELCAMSEKQEQLYSGLFNRLKKSINNLEKNTEMCNVMMQLRKMANHPLLHRQYYTPEKLKEMSQLMLKEPTHCEANPDLIFEDMEVMTDFELHVLCKQYQHINSYQLDMDLILDSGKFRALGCILSELKQKGDRVVLFSQFTMMLDILEVLLKHHQHRYLRLDGKTQISERIHLIDEFNTDMDIFVFLLSTKAGGLGINLTSANVVILHDIDCNPYNDKQAEDRCHRVGQTKEVLVIKLISQGTIEESMLKINQQKLKLEQDMTTVDEADEGSMPADIATLLKTSMGL
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: Protein that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Combines the ATP-dependent ability to exchange histones, with the chaperone-like ATP-independent activity to deposit histones and assemble nucleosomes. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. {ECO:0000250|UniProtKB:Q9H4L7}.
uniprot
proteins
mass_dalton
116451
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at the C-terminus promotes histone binding but impedes nucleosome binding. Phosphorylation impedes ATPase activity and histone exchange activity. {ECO:0000250|UniProtKB:Q9H4L7}.
uniprot
proteins
protein_family
SNF2/RAD54 helicase family
uniprot
proteins
pubmed
10415348
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
1489724
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17622165
uniprot
proteins
pubmed
18675275
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21549307
uniprot
proteins
pubmed
8219362
uniprot
proteins
sequence_length
1021
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H4L7}. Chromosome {ECO:0000250|UniProtKB:Q9H4L7}. Note=Colocalizes with PCNA at replication forks during S phase. Recruited to double-strand breaks (DSBs) sites of DNA damage. {ECO:0000250|UniProtKB:Q9H4L7}.
uniprot
proteins