ENPP4
entrez
22875
canonical
uniprot
Q9Y6X5
canonical
ensembl
ENSG00000001561
resolver
ensp
ENSP00000318066
resolver
ensp
ENSP00000633012
resolver
ensp
ENSP00000633014
resolver
enst
ENST00000321037
resolver
enst
ENST00000962953
resolver
enst
ENST00000962955
resolver
genesymbol
ENPP4
resolver
genesymbol_syn
KIAA0879
resolver
genesymbol_syn
NPP4
resolver
hgnc
HGNC:3359
resolver
uniprot
A8K5G1
resolver
uniprot
Q7L2N1
resolver
uniprot_entry
ENPP4_HUMAN
resolver
uniprot_sec
A8K5G1
resolver
uniprot_sec
Q7L2N1
resolver
amino_acid_sequence
MKLLVILLFSGLITGFRSDSSSSLPPKLLLVSFDGFRADYLKNYEFPHLQNFIKEGVLVEHVKNVFITKTFPNHYSIVTGLYEESHGIVANSMYDAVTKKHFSDSNDKDPFWWNEAVPIWVTNQLQENRSSAAAMWPGTDVPIHDTISSYFMNYNSSVSFEERLNNITMWLNNSNPPVTFATLYWEEPDASGHKYGPEDKENMSRVLKKIDDLIGDLVQRLKMLGLWENLNVIITSDHGMTQCSQDRLINLDSCIDHSYYTLIDLSPVAAILPKINRTEVYNKLKNCSPHMNVYLKEDIPNRFYYQHNDRIQPIILVADEGWTIVLNESSQKLGDHGYDNSLPSMHPFLAAHGPAFHKGYKHSTINIVDIYPMMCHILGLKPHPNNGTFGHTKCLLVDQWCINLPEAIAIVIGSLLVLTMLTCLIIIMQNRLSVPRPFSRLQLQEDDDDPLIG
uniprot
proteins
ec_number
3.6.1.29
uniprot
proteins
function
FUNCTION: Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors. {ECO:0000269|PubMed:22995898, ECO:0000269|PubMed:24338010}.
uniprot
proteins
mass_dalton
51641
uniprot
proteins
protein_family
Nucleotide pyrophosphatase/phosphodiesterase family
uniprot
proteins
pubmed
10048485
uniprot
proteins
pubmed
11027689
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22995898
uniprot
proteins
pubmed
24338010
uniprot
proteins
sequence_length
453
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22995898}; Single-pass type I membrane protein {ECO:0000269|PubMed:22995898}.
uniprot
proteins
transmembrane_region
TRANSMEM 408..428; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins