BAG4
entrez
9530
canonical
uniprot
O95429
canonical
ensembl
ENSG00000156735
resolver
ensp
ENSP00000287322
resolver
ensp
ENSP00000393298
resolver
genesymbol
BAG4
resolver
genesymbol_syn
SODD
resolver
hgnc
HGNC:940
resolver
uniprot
B4E217
resolver
uniprot
O95818
resolver
uniprot_entry
BAG4_HUMAN
resolver
uniprot_sec
B4E217
resolver
uniprot_sec
O95818
resolver
amino_acid_sequence
MSALRRSGYGPSDGPSYGRYYGPGGGDVPVHPPPPLYPLRPEPPQPPISWRVRGGGPAETTWLGEGGGGDGYYPSGGAWPEPGRAGGSHQEQPPYPSYNSNYWNSTARSRAPYPSTYPVRPELQGQSLNSYTNGAYGPTYPPGPGANTASYSGAYYAPGYTQTSYSTEVPSTYRSSGNSPTPVSRWIYPQQDCQTEAPPLRGQVPGYPPSQNPGMTLPHYPYGDGNRSVPQSGPTVRPQEDAWASPGAYGMGGRYPWPSSAPSAPPGNLYMTESTSPWPSSGSPQSPPSPPVQQPKDSSYPYSQSDQSMNRHNFPCSVHQYESSGTVNNDDSDLLDSQVQYSAEPQLYGNATSDHPNNQDQSSSLPEECVPSDESTPPSIKKIIHVLEKVQYLEQEVEEFVGKKTDKAYWLLEEMLTKELLELDSVETGGQDSVRQARKEAVCKIQAILEKLEKKGL
uniprot
proteins
function
FUNCTION: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release (By similarity). Prevents constitutive TNFRSF1A signaling. Negative regulator of PRKN translocation to damaged mitochondria. {ECO:0000250, ECO:0000269|PubMed:24270810}.
uniprot
proteins
mass_dalton
49594
uniprot
proteins
mutagenesis
MUTAGEN 414; /note="E->A: Reduces interaction with HSP70."; /evidence="ECO:0000269|PubMed:12058034"; MUTAGEN 424; /note="D->A: Abolishes interaction with HSP70."; /evidence="ECO:0000269|PubMed:12058034"; MUTAGEN 438..439; /note="RK->AA: Reduces interaction with HSP70."; /evidence="ECO:0000269|PubMed:12058034"; MUTAGEN 446; /note="Q->A: Abolishes interaction with HSP70."; /evidence="ECO:0000269|PubMed:12058034
uniprot
proteins
pubmed
12058034
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24270810
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9873016
uniprot
proteins
pubmed
9915703
uniprot
proteins
sequence_length
457
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins