Tcf3
entrez
171046
canonical
uniprot
P21677
canonical
ensembl
ENSRNOG00000051499
resolver
ensp
ENSRNOP00000071280
resolver
ensp
ENSRNOP00000074654
resolver
genesymbol
Tcf3
resolver
genesymbol_syn
Pan
resolver
genesymbol_syn
Ptf1c
resolver
genesymbol_syn
Tcfe2a
resolver
uniprot
E9PTG9
resolver
uniprot
P21676
resolver
uniprot
Q08440
resolver
uniprot
Q4VY47
resolver
uniprot
Q68G29
resolver
uniprot_entry
Q68G29_RAT
resolver
uniprot_entry
TFE2_RAT
resolver
uniprot_sec
E9PTG9
resolver
uniprot_sec
P21676
resolver
uniprot_sec
Q08440
resolver
uniprot_sec
Q4VY47
resolver
amino_acid_sequence
MMNQSQRMAPVGSDKELSDLLDFSMMFPLPVANGKGRPASLAGTQFAGSGLEDRPSSESWGNSEQNSSSFDPSRAYSEGAHFSDSHSSLPPSTFLGAGLGGKGSERNAYATFGRDTSVGTLSQAGFLPGELGLSSPGPLSPSGVKSSSQYYTSFPSNPRRRAADGGLDTQPKKVRKVPPGLPSSVYPSSSGDNYSRDATAYPSAKTPSSAYPSPFYVADGSLHPSAELWSPPGQVGFGPMLGDGSAPLPLAPGSSSVSSGAFGGLQQQDRMGYQLHGSEVNGTLPAVSSFSAAPGTYSGTSGHTPPVSGADSLLGTRGTTASSSGDALGKALASIYSPDHSSNNFSPSPSTPVGSPQGLPGTSQWPRAGAPSALSPNYDAGLHGLSKMEDRLDEAIHVLRSHAVGTASELHGLLPGHSTLTTSFAGPMSLGGRHAGLVSGSHPEDGLTSGASLLHNHASLPSQPSSLPDLSQRPPDSFSGLGRAGVTAGASEIKREEKEDEEVTSVADAEEDKKDLKVPRTRTSPDEDEDDLLPPEQKAEREKERRVANNARERLRVRDINEAFKELGRMCQLHLSTEKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSGVVGDPQLALSAAHPGLGEAHNPAGHL
uniprot
proteins
function
FUNCTION: Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (By similarity). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (By similarity). Together with TCF15, required for the mesenchymal to epithelial transition (By similarity). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (By similarity). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (By similarity). Binds to the consensus sequence CAC/GCTGT/C present, in the chymotrypsin, insulin, AP-4, and several other gene enhancer motifs (PubMed:2200736). {ECO:0000250|UniProtKB:P15806, ECO:0000250|UniProtKB:P15923, ECO:0000269|PubMed:2200736}.; FUNCTION: [Isoform E47]: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity. {ECO:0000250|UniProtKB:P15923}.
uniprot
proteins
mass_dalton
67655
uniprot
proteins
post_translational_modification
PTM: Phosphorylated following NGF stimulation.; PTM: Undergoes Notch-induced ubiquitination and subsequent proteasomal degradation which is mediated by ASB1 or ASB2, the substrate-recognition components of probable ECS E3 ubiquitin-protein ligase complexes. {ECO:0000250|UniProtKB:P15923}.
uniprot
proteins
pubmed
1766666
uniprot
proteins
pubmed
2200736
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9013644
uniprot
proteins
sequence_length
649
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P15806}.
uniprot
proteins