Rbm8a
entrez
295284
canonical
uniprot
Q27W01
canonical
ensembl
ENSRNOG00000021215
resolver
ensembl
ENSRNOG00055032492
resolver
ensembl
ENSRNOG00060012608
resolver
ensembl
ENSRNOG00065032176
resolver
ensp
ENSRNOP00000028807
resolver
ensp
ENSRNOP00055046282
resolver
ensp
ENSRNOP00060016906
resolver
ensp
ENSRNOP00065045582
resolver
enst
ENSRNOT00000028807
resolver
enst
ENSRNOT00055056129
resolver
enst
ENSRNOT00060021407
resolver
enst
ENSRNOT00065055410
resolver
genesymbol
Rbm8a
resolver
genesymbol_syn
Rbm8
resolver
uniprot_entry
RBM8A_RAT
resolver
amino_acid_sequence
MADVLDLHEAGGEDFAMDEDGDESIHKLKEKAKKRKGRGFGSEEGSRARMREDYDSVEQDGDEPGPQRSVEGWILFVTGVHEEATEEDIHDKFAEYGEIKNIHLNLDRRTGYLKGYTLVEYETYKEAQAAMEGLNGQDLMGQPISVDWCFVRGPPKGKRRGGRRRSRSPDRRRR
uniprot
proteins
function
FUNCTION: Required for pre-mRNA splicing as component of the spliceosome (By similarity). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs (By similarity). {ECO:0000250|UniProtKB:Q9Y5S9}.
uniprot
proteins
mass_dalton
19889
uniprot
proteins
protein_family
RBM8A family
uniprot
proteins
pubmed
16275927
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
174
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16275927}. Nucleus speckle {ECO:0000269|PubMed:16275927}. Cytoplasm {ECO:0000269|PubMed:16275927}. Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles. {ECO:0000250|UniProtKB:Q9Y5S9}.
uniprot
proteins