ST6GAL1
entrez
6480
canonical
uniprot
P15907
canonical
ensembl
ENSG00000073849
resolver
ensp
ENSP00000169298
resolver
ensp
ENSP00000389337
resolver
ensp
ENSP00000412221
resolver
ensp
ENSP00000549790
resolver
genesymbol
ST6GAL1
resolver
genesymbol_syn
SIAT1
resolver
hgnc
HGNC:10860
resolver
uniprot
A8KA14
resolver
uniprot
B2R513
resolver
uniprot
D3DNV3
resolver
uniprot_entry
SIAT1_HUMAN
resolver
uniprot_sec
A8KA14
resolver
uniprot_sec
B2R513
resolver
uniprot_sec
D3DNV3
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by CTP. {ECO:0000269|PubMed:23999306}.
uniprot
proteins
amino_acid_sequence
MIHTNLKKKFSCCVLVFLLFAVICVWKEKKKGSYYDSFKLQTKEFQVLKSLGKLAMGSDSQSVSSSSTQDPHRGRQTLGSLRGLAKAKPEASFQVWNKDSSSKNLIPRLQKIWKNYLSMNKYKVSYKGPGPGIKFSAEALRCHLRDHVNVSMVEVTDFPFNTSEWEGYLPKESIRTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLVTTEKRFLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYNFFNNYKTYRKLHPNQPFYILKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYYQKFFDSACTMGAYHPLLYEKNLVKHLNQGTDEDIYLLGKATLPGFRTIHC
uniprot
proteins
ec_number
2.4.3.1
uniprot
proteins
function
FUNCTION: Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates. In B lymphocytes, generates neuraminidase-sensitive lymphocyte cell-surface differentiation antigens, such as CDw75, HB-6 and CD76 (PubMed:1730763). Sialylates complex-type N-glycans attached on the fragment crystallizable (Fc) of IgGs conferring anti-inflammatory effector functions. Preferentially monosialylates the alpha(1->3) mannose antenna of Fc glycoforms with subsequent disialylation occurring at a much slower rate. {ECO:0000269|PubMed:1730763, ECO:0000269|PubMed:21081508, ECO:0000269|PubMed:23999306, ECO:0000269|PubMed:25733881, ECO:0000269|PubMed:27872474, ECO:0000269|PubMed:36280670, ECO:0000269|PubMed:37632720}.
uniprot
proteins
mass_dalton
46605
uniprot
proteins
mutagenesis
MUTAGEN 24; /note="C->G: No effect on dimerization and on location at the Golgi stack."; /evidence="ECO:0000269|PubMed:20378551
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:27872474, ECO:0000269|PubMed:29133956, ECO:0000269|PubMed:36280670}.
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:23999306}.
uniprot
proteins
protein_family
Glycosyltransferase 29 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
1547499
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
1730763
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20378551
uniprot
proteins
pubmed
21081508
uniprot
proteins
pubmed
2373995
uniprot
proteins
pubmed
23999306
uniprot
proteins
pubmed
2408023
uniprot
proteins
pubmed
25733881
uniprot
proteins
pubmed
27872474
uniprot
proteins
pubmed
2803295
uniprot
proteins
pubmed
29133956
uniprot
proteins
pubmed
35789385
uniprot
proteins
pubmed
36280670
uniprot
proteins
pubmed
37632720
uniprot
proteins
sequence_length
406
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:1730763, ECO:0000269|PubMed:20378551, ECO:0000269|PubMed:29133956}; Single-pass type II membrane protein {ECO:0000305}. Secreted {ECO:0000250|UniProtKB:P13721}. Note=Membrane-bound form in trans cisternae of Golgi (PubMed:20378551). Secreted into the body fluid (By similarity). Colocalizes with MGAT3 and B4GALT1 in the Golgi stacks of cisternae, including the cis-part of the Golgi stacks. {ECO:0000250|UniProtKB:P13721, ECO:0000269|PubMed:20378551, ECO:0000269|PubMed:29133956}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..26; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins