Pgrmc1
entrez
291948
canonical
uniprot
P70580
canonical
ensembl
ENSRNOG00000012786
resolver
ensembl
ENSRNOG00055025275
resolver
ensembl
ENSRNOG00060019057
resolver
ensembl
ENSRNOG00065010138
resolver
ensp
ENSRNOP00000017101
resolver
ensp
ENSRNOP00055035572
resolver
ensp
ENSRNOP00060026949
resolver
ensp
ENSRNOP00065012396
resolver
enst
ENSRNOT00000017101
resolver
enst
ENSRNOT00055043581
resolver
enst
ENSRNOT00060032952
resolver
enst
ENSRNOT00065016336
resolver
genesymbol
Pgrmc1
resolver
genesymbol_syn
25dx
resolver
genesymbol_syn
Lewi
resolver
genesymbol_syn
Pgrmc
resolver
uniprot
O70606
resolver
uniprot
Q549C4
resolver
uniprot_entry
PGRC1_RAT
resolver
uniprot_sec
O70606
resolver
uniprot_sec
Q549C4
resolver
amino_acid_sequence
MAAEDVVATGADPSELEGGGLLQEIFTSPLNLLLLGLCIFLLYKIVRGDQPGASGDNDDDEPPPLPRLKPRDFTPAELRRYDGVQDPRILMAINGKVFDVTKGRKFYGPEGPYGVFAGRDASRGLATFCLDKEALKDEYDDLSDLTPAQQETLNDWDSQFTFKYHHVGKLLKEGEEPTVYSDDEEPKDEAARKSD
uniprot
proteins
function
FUNCTION: Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (By similarity). May be implicated in 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) immunotoxicity (PubMed:9006096). Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization (By similarity). {ECO:0000250|UniProtKB:O00264, ECO:0000269|PubMed:9006096}.
uniprot
proteins
mass_dalton
21598
uniprot
proteins
post_translational_modification
PTM: O-glycosylated; contains chondroitin sulfate attached to Ser-54. Ser-54 is in the cytoplasmic domain but the glycosylated form was detected in urine, suggesting that the membrane-bound form is cleaved, allowing for production of a secreted form which is glycosylated. {ECO:0000250|UniProtKB:O00264}.
uniprot
proteins
protein_family
Cytochrome b5 family
uniprot
proteins
protein_family
MAPR subfamily
uniprot
proteins
pubmed
10656251
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9006096
uniprot
proteins
sequence_length
195
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000250|UniProtKB:Q95250}; Single-pass membrane protein {ECO:0000255}. Smooth endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O00264}; Single-pass membrane protein {ECO:0000255}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:O55022}; Single-pass membrane protein {ECO:0000250|UniProtKB:O00264}; Extracellular side {ECO:0000250|UniProtKB:O55022}. Secreted {ECO:0000250|UniProtKB:O00264}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..43; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins