Abcd1
entrez
11666
canonical
uniprot
P48410
canonical
ensembl
ENSMUSG00000031378
resolver
ensp
ENSMUSP00000002084
resolver
enst
ENSMUST00000002084
resolver
genesymbol
Abcd1
resolver
genesymbol_syn
Ald
resolver
genesymbol_syn
Aldgh
resolver
uniprot
Q9QY41
resolver
uniprot
Q9QZ32
resolver
uniprot_entry
ABCD1_MOUSE
resolver
uniprot_sec
Q9QY41
resolver
uniprot_sec
Q9QZ32
resolver
amino_acid_sequence
MPVLSTPRPSRVTTLKRTAVVLALTAYGVHKIYPLVRQCLTPARGPQVPAGEPTQEASGATATKAGMNRVFLQRLLALLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDGRLARCIVRKDPRAFSWQLLQWLLIALPATFINSAIRYLEGQLALSFRSRLVAHAYGLYFSQQTYYRVSNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGTAWPSAIAGLVVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHEVELALLQHSYQDLASQINLILLERLWYVMLEQFLMKYVWSASGLLMVAVPIITATGYAESDSEAMKKAALEMKEEELVSERTEAFTIARNLLTAAADATERIMSSYKEVTELAGYTARVYEMFQVFEDVKHCRFKRTGDLEEAQAGPGVMVQSGVHVEGPLKIQGQVVDVEQGIICENIPIITPTGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYSGVLYKPPPQRMFYIPQRPYMSVGSLRDQVIYPDSAEDMRRKGCSEQQLEAILGIVHLRHILQREGGWEAVCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDAGIALLSITHRPSLWKYHTHLLQFDGEGGWKFEKLDSAARLSLTEEKQRLEQQLAGIPKMQGRLQELRQILGEAAAPVQPLVPGVPT
uniprot
proteins
ec_number
3.1.2.-
uniprot
proteins
ec_number
7.6.2.-
uniprot
proteins
function
FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family involved in the transport of very long chain fatty acid (VLCFA)-CoA from the cytosol to the peroxisome lumen. Has fatty acyl-CoA thioesterase (ACOT) and ATPase activities. Coupled to the ATP-dependent transporter activity also has a fatty acyl-CoA thioesterase activity (ACOT) and hydrolyzes VLCFA-CoA into VLCFA prior their ATP-dependent transport into peroxisomes, the ACOT activity is essential during this transport process (By similarity). Thus, plays a role in regulation of VLCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation, mitochondrial function and microsomal fatty acid elongation (PubMed:18854420, PubMed:23123468, PubMed:23604518, PubMed:25255441, PubMed:25583114, PubMed:26108493, PubMed:9126326, PubMed:9256488, PubMed:9418970). Involved in several processes; namely, controls the active myelination phase by negatively regulating the microsomal fatty acid elongation activity and may also play a role in axon and myelin maintenance (PubMed:11875044, PubMed:15489218, PubMed:26108493). Also controls the cellular response to oxidative stress by regulating mitochondrial functions such as mitochondrial oxidative phosphorylation and depolarization (PubMed:18344354, PubMed:22521832, PubMed:23604518, PubMed:25583114). And finally controls the inflammatory response by positively regulating peroxisomal beta-oxidation of VLCFAs (PubMed:18723473). {ECO:0000250|UniProtKB:P33897, ECO:0000269|PubMed:11875044, ECO:0000269|PubMed:15489218, ECO:0000269|PubMed:18344354, ECO:0000269|PubMed:18723473, ECO:0000269|PubMed:18854420, ECO:0000269|PubMed:22521832, ECO:0000269|PubMed:23123468, ECO:0000269|PubMed:23604518, ECO:0000269|PubMed:25255441, ECO:0000269|PubMed:25583114, ECO:0000269|PubMed:26108493, ECO:0000269|PubMed:9126326, ECO:0000269|PubMed:9256488, ECO:0000269|PubMed:9418970}.
uniprot
proteins
mass_dalton
81859
uniprot
proteins
post_translational_modification
PTM: Tyrosine-phosphorylated. {ECO:0000250|UniProtKB:D3ZHR2}.
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCD family
uniprot
proteins
protein_family
Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily
uniprot
proteins
pubmed
10504404
uniprot
proteins
pubmed
11875044
uniprot
proteins
pubmed
15276650
uniprot
proteins
pubmed
15489218
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18344354
uniprot
proteins
pubmed
18723473
uniprot
proteins
pubmed
18854420
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22521832
uniprot
proteins
pubmed
23123468
uniprot
proteins
pubmed
23604518
uniprot
proteins
pubmed
25255441
uniprot
proteins
pubmed
25583114
uniprot
proteins
pubmed
26108493
uniprot
proteins
pubmed
7894167
uniprot
proteins
pubmed
9126326
uniprot
proteins
pubmed
9256488
uniprot
proteins
pubmed
9418970
uniprot
proteins
sequence_length
736
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250|UniProtKB:P33897}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000250|UniProtKB:P33897}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P33897}. Lysosome membrane {ECO:0000250|UniProtKB:P33897}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P33897}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P33897}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P33897}.
uniprot
proteins
transmembrane_region
TRANSMEM 92..112; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 131..151; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 238..258; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 338..358; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 473..493; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441
uniprot
proteins