Phox2b
entrez
18935
canonical
uniprot
O35690
canonical
ensembl
ENSMUSG00000012520
resolver
ensp
ENSMUSP00000012664
resolver
enst
ENSMUST00000012664
resolver
genesymbol
Phox2b
resolver
genesymbol_syn
Pmx2b
resolver
uniprot_entry
PHX2B_MOUSE
resolver
amino_acid_sequence
MYKMEYSYLNSSAYESCMAGMDTSSLASAYADFSSCSQASGFQYNPIRTTFGATSGCPSLTPGSCSLGTLRDHQSSPYAAVPYKLFTDHGGLNEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARVQVWFQNRRAKFRKQERAAAAAAAAAKNGSSGKKSDSSRDDESKEAKSTDPDSTGGPGPNPNPTPSCGANGGGGGGPSPAGAPGAAGPGGPGGEPGKGGAAAAAAAAAAAAAAAAAAAAGGLAAAGGPGQGWAPGPGPITSIPDSLGGPFASVLSSLQRPNGAKAALVKSSMF
uniprot
proteins
function
FUNCTION: Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus (PubMed:32094113). Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum-response element. {ECO:0000269|PubMed:32094113}.
uniprot
proteins
mass_dalton
31621
uniprot
proteins
mutagenesis
MUTAGEN 185; /note="K->R: Complete loss of monoubiquitination."; /evidence="ECO:0000269|PubMed:32094113
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated at Lys-185 by the RNF220/ZC4H2 complex; leading to enhanced DNA-binding ability and transactivity. {ECO:0000269|PubMed:32094113}.
uniprot
proteins
protein_family
Paired homeobox family
uniprot
proteins
pubmed
10395798
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18275850
uniprot
proteins
pubmed
32094113
uniprot
proteins
pubmed
9374403
uniprot
proteins
sequence_length
314
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
uniprot
proteins