Cd74
entrez
25599
canonical
uniprot
P10247
canonical
ensembl
ENSRNOG00000018735
resolver
ensembl
ENSRNOG00055015091
resolver
ensembl
ENSRNOG00060021325
resolver
ensembl
ENSRNOG00065023066
resolver
ensp
ENSRNOP00000025354
resolver
ensp
ENSRNOP00000106590
resolver
genesymbol
Cd74
resolver
uniprot
Q6GT70
resolver
uniprot_entry
HG2A_RAT
resolver
uniprot_entry
Q6GT70_RAT
resolver
amino_acid_sequence
MDDQRDLISNHEQLPILGQRARAPESNCNRGVLYTSVSVLVALLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKSAKPVSPMRMATPLLMRPLSMDNMLQAPVKNVTKYGNMTQDHVMHLLTKSGPVNYPQLKGSFPENLKHLKNSMNGLDWKVFESWMKQWLLFEMSKNSLEEKQPTQTPPKVLTKCQEEVSHIPDVHPGAFRPKCDENGNYMPLQCHGSTGYCWCVFPNGTEVPHTKSRGRHNCSEPLDMEDPSSGLGVTKQDMGQMFL
uniprot
proteins
function
FUNCTION: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to compartments where peptide loading of class II takes place. Enhance also the stimulation of T-cell responses through interaction with CD44. {ECO:0000250|UniProtKB:P04441}.; FUNCTION: [Class-II-associated invariant chain peptide]: Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome. {ECO:0000250|UniProtKB:P04233}.; FUNCTION: [Isoform Long]: Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). {ECO:0000250|UniProtKB:P04441}.
uniprot
proteins
mass_dalton
31642
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2499873
uniprot
proteins
pubmed
3264906
uniprot
proteins
sequence_length
280
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform Long]: Late endosome {ECO:0000250|UniProtKB:P04441}. Lysosome {ECO:0000250|UniProtKB:P04441}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P04233}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P04233}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P04233}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:P04233}. Endosome {ECO:0000250|UniProtKB:P04233}. Lysosome {ECO:0000250|UniProtKB:P04233}. Secreted {ECO:0000250|UniProtKB:P04233}. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane. {ECO:0000250|UniProtKB:P04233}.
uniprot
proteins
transmembrane_region
TRANSMEM 31..56; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins