Soat2
entrez
223920
canonical
uniprot
O88908
canonical
ensembl
ENSMUSG00000023045
resolver
ensp
ENSMUSP00000023806
resolver
enst
ENSMUST00000023806
resolver
genesymbol
Soat2
resolver
genesymbol_syn
Acact-2
resolver
genesymbol_syn
Acat2
resolver
uniprot
Q8R0Y9
resolver
uniprot_entry
SOAT2_MOUSE
resolver
uniprot_sec
Q8R0Y9
resolver
amino_acid_sequence
MQPKVPQLRRREGLGEEQEKGARGGEGNARTHGTPDLVQWTRHMEAVKTQFLEQAQRELAELLDRALWEAMQAYPKQDRPLPSAAPDSTSKTQELHPGKRKVFITRKSLIDELMEVQHFRTIYHMFIAGLCVLIISTLAIDFIDEGRLMLEFDLLLFSFGQLPLALMTWVPMFLSTLLVPYQTLWLWARPRAGGAWMLGASLGCVLLAAHAVVLCVLPVHVSVRHELPPASRCVLVFEQVRLLMKSYSFLRETVPGIFCVRGGKGISPPSFSSYLYFLFCPTLIYRETYPRTPSIRWNYVAKNFAQVLGCLLYACFILGRLCVPVFANMSREPFSTRALLLSILHATGPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLWLLGRRARGVAMLGVFLVSAVVHEYIFCFVLGFFYPVMLMLFLVFGGLLNFTMNDRHTGPAWNILMWTFLFMGQGIQVSLYCQEWYARRHCPLPQTTFWGMVTPRSWSCHP
uniprot
proteins
ec_number
2.3.1.26
uniprot
proteins
function
FUNCTION: Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) and linolenoyl-CoA ((9Z,12Z,15Z)-octadecatrienoyl-CoA) as substrates. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa. {ECO:0000250|UniProtKB:O75908}.
uniprot
proteins
mass_dalton
60597
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated by AMFR/gp78 at Cys-280, leading to its degradation when the lipid levels are low. Association with AMFR/gp78 is mediated via interaction with INSIG1. High concentration of cholesterol and fatty acid results in Cys-280 oxidation, preventing ubiquitination at the same site, resulting in protein stabilization. {ECO:0000250|UniProtKB:O75908}.; PTM: Oxidized at Cys-280: high concentration of cholesterol and fatty acid induce reactive oxygen species, which oxidizes Cys-280, preventing ubiquitination at the same site, and resulting in protein stabilization. {ECO:0000250|UniProtKB:O75908}.
uniprot
proteins
protein_family
Membrane-bound acyltransferase family
uniprot
proteins
protein_family
Sterol o-acyltransferase subfamily
uniprot
proteins
pubmed
11071899
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28604676
uniprot
proteins
pubmed
29184177
uniprot
proteins
pubmed
9756919
uniprot
proteins
sequence_length
525
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11071899}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 120..141; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P35610"; TRANSMEM 162..187; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P35610"; TRANSMEM 200..223; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P35610"; TRANSMEM 232..255; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P35610"; TRANSMEM 297..329; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P35610"; TRANSMEM 347..372; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P35610"; TRANSMEM 421..445; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P35610"; TRANSMEM 452..467; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P35610"; TRANSMEM 474..505; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:P35610
uniprot
proteins