Q5SZ93
uniprot
Q5SZ93
canonical
amino_acid_sequence
MATVVEMSPTSEQSEFVLGTPVNKKTPALKVPSLCSMRYGIAFVTHFCNFTLMAQNSIISITMVAMVNNTDHPPHLNSSTEQLPAGLSGDQHEASKHLPIKGTGYGGQFALWQKWAPPNERSRLCTIALSGMTLGIFTVLLVGGIISEALGWPFVFYSFGGGGVLCSLLWFILIYDDPVSHPWISGPEREYILSSLNQQFSSEEQPLPIKAMLKSLPLWSMCLCTMTHQWLVNTFIMYTPTYISSVFKVNIRDNGFLSSLPFIVAWVLGILGGWLADFLLSKNFRLITVRKFITLLGNAPPAALVAALPYIQSSYITTIIFLTISCGLCPLSQAGIYINALDIAPRYASFLMGTSRGLAHSSAVLVPIVAGFFLSQDSEFGWRNFFFVVFAVNLLGLIIYLVFGKADVQEWARERKLTRL
uniprot
proteins
function
FUNCTION: Transports organic anions in a voltage-driven, multispecific, manner, on the apical side of renal proximal tubule. Mediates the renal excretion of uric acid and the uremic toxin 3-indoxyl sulfate. {ECO:0000269|PubMed:38641061}.
uniprot
proteins
mass_dalton
46377
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Sodium/anion cotransporter family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
38641061
uniprot
proteins
sequence_length
420
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O00476}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 47..67; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 126..146; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 154..174; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 216..236; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 260..280; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 286..308; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 315..337; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 357..377; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 384..404; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins