SLC8A3
entrez
6547
canonical
uniprot
P57103
canonical
ensembl
ENSG00000100678
resolver
ensp
ENSP00000216568
resolver
ensp
ENSP00000349392
resolver
ensp
ENSP00000370669
resolver
ensp
ENSP00000377863
resolver
ensp
ENSP00000433531
resolver
ensp
ENSP00000436688
resolver
ensp
ENSP00000516120
resolver
ensp
ENSP00000636084
resolver
ensp
ENSP00000636085
resolver
genesymbol
SLC8A3
resolver
genesymbol_syn
NCX3
resolver
hgnc
HGNC:11070
resolver
uniprot
B3KU59
resolver
uniprot
Q5K3P6
resolver
uniprot
Q5K3P7
resolver
uniprot
Q8IUE9
resolver
uniprot
Q8IUF0
resolver
uniprot
Q8NFI7
resolver
uniprot
Q96QG1
resolver
uniprot
Q96QG2
resolver
uniprot_entry
B3KU59_HUMAN
resolver
uniprot_entry
NAC3_HUMAN
resolver
uniprot_sec
Q5K3P6
resolver
uniprot_sec
Q5K3P7
resolver
uniprot_sec
Q8IUE9
resolver
uniprot_sec
Q8IUF0
resolver
uniprot_sec
Q8NFI7
resolver
uniprot_sec
Q96QG1
resolver
uniprot_sec
Q96QG2
resolver
activity_regulation
ACTIVITY REGULATION: Calcium transport is down-regulated by Na(+) and stimulated by Ca(2+). {ECO:0000250|UniProtKB:P70549}.
uniprot
proteins
amino_acid_sequence
MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAGGSGDVPSTGQNNESCSGSSDCKEGVILPIWYPENPSLGDKIARVIVYFVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGFIAGDLGPSTIVGSAAFNMFIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPKGIEMDGKMMNSHFLDGNLVPLEGKEVDESRREMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERGISALLLSPDVTDRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSAAGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTIFAFVCISVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF
uniprot
proteins
function
FUNCTION: Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (By similarity). Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935). Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis (By similarity). {ECO:0000250|UniProtKB:S4R2P9, ECO:0000269|PubMed:21959935}.
uniprot
proteins
mass_dalton
103010
uniprot
proteins
protein_family
Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family
uniprot
proteins
protein_family
SLC8 subfamily
uniprot
proteins
pubmed
12406570
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
12558991
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15777725
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
21959935
uniprot
proteins
pubmed
23506867
uniprot
proteins
sequence_length
927
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21959935}; Multi-pass membrane protein {ECO:0000305}. Perikaryon {ECO:0000250|UniProtKB:P70549}. Cell projection, dendrite {ECO:0000250|UniProtKB:P70549}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:P70549}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:S4R2P9}. Cytoplasm, sarcoplasm {ECO:0000250|UniProtKB:S4R2P9}. Cell junction {ECO:0000250|UniProtKB:S4R2P9}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:S4R2P9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:S4R2P9}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:21959935}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:21959935}; Multi-pass membrane protein {ECO:0000250|UniProtKB:S4R2P9}. Note=Detected at neuromuscular junctions. {ECO:0000250|UniProtKB:S4R2P9}.
uniprot
proteins
transmembrane_region
TRANSMEM 74..94; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 148..168; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 170..190; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 203..223; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 231..251; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 727..747; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 755..775; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 779..799; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 829..849; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 861..881; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 904..924; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins