Eif4ebp1
entrez
116636
canonical
uniprot
Q62622
canonical
ensembl
ENSRNOG00000081081
resolver
ensembl
ENSRNOG00055007988
resolver
ensembl
ENSRNOG00060012306
resolver
ensembl
ENSRNOG00065002728
resolver
ensp
ENSRNOP00000087155
resolver
ensp
ENSRNOP00055010788
resolver
ensp
ENSRNOP00060016441
resolver
ensp
ENSRNOP00065002588
resolver
enst
ENSRNOT00000096679
resolver
enst
ENSRNOT00055013467
resolver
enst
ENSRNOT00060020858
resolver
enst
ENSRNOT00065003710
resolver
genesymbol
Eif4ebp1
resolver
uniprot_entry
4EBP1_RAT
resolver
amino_acid_sequence
MSAGSSCSQTPSRAIPTRRVALGDGVQLPPGDYSTTPGGTLFSTTPGGTRIIYDRKFLMECRNSPVAKTPPKDLPTIPGVTSPTSDEPPMQASQSHLHSSPEDKRAGGEESQFEMDI
uniprot
proteins
function
FUNCTION: Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (PubMed:7939721). {ECO:0000250|UniProtKB:Q13541, ECO:0000269|PubMed:7939721}.
uniprot
proteins
mass_dalton
12404
uniprot
proteins
mutagenesis
MUTAGEN 64; /note="S->A: Decreases phosphorylation by MAPK1 and MAPK3."; /evidence="ECO:0000269|PubMed:7939721
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylation at Thr-36, Thr-45, Ser-64 and Thr-69, corresponding to the hyperphosphorylated form, is regulated by mTORC1 and abolishes binding to EIF4E. {ECO:0000269|PubMed:7939721, ECO:0000269|PubMed:8170978}.; PTM: Ubiquitinated: when eIF4E levels are low, hypophosphorylated form is ubiquitinated by the BCR(KLHL25) complex, leading to its degradation and serving as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. Not ubiquitinated when hyperphosphorylated (at Thr-36, Thr-45, Ser-64 and Thr-69) or associated with eIF4E. {ECO:0000250|UniProtKB:Q13541}.
uniprot
proteins
protein_family
EIF4E-binding protein family
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7939721
uniprot
proteins
pubmed
8170978
uniprot
proteins
sequence_length
117
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q60876}. Nucleus {ECO:0000250|UniProtKB:Q60876}. Note=Localization to the nucleus is unaffected by phosphorylation status. {ECO:0000250|UniProtKB:Q60876}.
uniprot
proteins