CTHRC1
entrez
115908
canonical
uniprot
Q96CG8
canonical
ensembl
ENSG00000164932
resolver
ensp
ENSP00000330523
resolver
ensp
ENSP00000430550
resolver
ensp
ENSP00000789063
resolver
genesymbol
CTHRC1
resolver
hgnc
HGNC:18831
resolver
uniprot
G3V141
resolver
uniprot
Q6UW91
resolver
uniprot
Q8IX63
resolver
uniprot_entry
CTHR1_HUMAN
resolver
uniprot_sec
G3V141
resolver
uniprot_sec
Q6UW91
resolver
uniprot_sec
Q8IX63
resolver
amino_acid_sequence
MRPQGPAASPQRLRGLLLLLLLQLPAPSSASEIPKGKQKAQLRQREVVDLYNGMCLQGPAGVPGRDGSPGANGIPGTPGIPGRDGFKGEKGECLRESFEESWTPNYKQCSWSSLNYGIDLGKIAECTFTKMRSNSALRVLFSGSLRLKCRNACCQRWYFTFNGAECSGPLPIEAIIYLDQGSPEMNSTINIHRTSSVEGLCEGIGAGLVDVAIWVGTCSDYPKGDASTGWNSVSRIIIEELPK
uniprot
proteins
disease_involvement
DISEASE: Barrett esophagus (BE) [MIM:614266]: A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. {ECO:0000269|PubMed:21791690}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: May act as a negative regulator of collagen matrix deposition. {ECO:0000250}.
uniprot
proteins
mass_dalton
26224
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250}.
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15618538
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
21791690
uniprot
proteins
sequence_length
243
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
uniprot
proteins