Mbd1
entrez
17190
canonical
uniprot
Q9Z2E2
canonical
ensembl
ENSMUSG00000024561
resolver
ensp
ENSMUSP00000095137
resolver
ensp
ENSMUSP00000153428
resolver
ensp
ENSMUSP00000270545
resolver
ensp
ENSMUSP00000270555
resolver
ensp
ENSMUSP00000270566
resolver
ensp
ENSMUSP00000270572
resolver
ensp
ENSMUSP00000270577
resolver
ensp
ENSMUSP00000270588
resolver
enst
ENSMUST00000097530
resolver
enst
ENSMUST00000224047
resolver
genesymbol
Mbd1
resolver
uniprot
A0A0R4J159
resolver
uniprot
A0A286YDI1
resolver
uniprot
Q3TMA4
resolver
uniprot
Q3U101
resolver
uniprot
Q6NSW0
resolver
uniprot
Q792D6
resolver
uniprot
Q8CCL9
resolver
uniprot
Q9DC19
resolver
uniprot_entry
A0A0R4J159_MOUSE
resolver
uniprot_entry
A0A286YDI1_MOUSE
resolver
uniprot_entry
MBD1_MOUSE
resolver
uniprot_sec
Q3TMA4
resolver
uniprot_sec
Q3U101
resolver
uniprot_sec
Q6NSW0
resolver
uniprot_sec
Q792D6
resolver
uniprot_sec
Q8CCL9
resolver
uniprot_sec
Q9DC19
resolver
amino_acid_sequence
MAESWQDCPALGPGWKRRESFRKSGASFGRSDIYYQSPTGEKIRSKVELTRYLGPACDLTLFDFRQGTLCHPIPKTHPLAVPSKKKKKPSKPAKTKKQQVGLQRSEVRIETPQGEYKAPTATALASLSVSASASSSASASASASSHAPVCCENCGIHFSWDGVKRQRLKTLCKDCRAQRIAFNREQRMFKRVGCGDCAACLVKEDCGVCSTCRLQLPSDVASGLYCKCERRRCLRIMEKSRGCGVCRGCQTQEDCGHCCICLRSPRPGLKRQWRCLQRRCFWGKRDSSKRGSKVASQRHSQAPPLPPHPASQYTEPTELHISDIAPTSPAEFIYYCVDEDEDELQPYTNQRQNRKCGACAACLRRMDCGRCDFCCDKPKFGGGNQKRQKCRWRQCLQFAMKRLLPSAGSGSGEGAGLRPYQTHQTHQKRPASARQLQLSSPLKAPWAVVTAPPGPVRDSRKQQAGRGSVLPQPDTDFVFLQEGTSSAMQMPGTAAASTEVPVQAAQCSAPSWVVALPQVKQETADAPEEWTAVTTFLTSSTLQSGFPSKAADPDLSPVKQEPPGPEEDGEEKKDDVSETTPAEEIGGVGTPVITEIFSLGGTRLRDAEAWLPRLHKLLAVNEKEYFTELQLKEEVL
uniprot
proteins
function
FUNCTION: Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 can also repress transcription from unmethylated promoters. {ECO:0000269|PubMed:15060159, ECO:0000269|PubMed:9774669}.
uniprot
proteins
mass_dalton
70023
uniprot
proteins
post_translational_modification
PTM: Sumoylated, sumoylation may increase interaction with ATF7IP. {ECO:0000250|UniProtKB:Q9UIS9}.
uniprot
proteins
pubmed
10441743
uniprot
proteins
pubmed
12697822
uniprot
proteins
pubmed
15060159
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15777793
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
9774669
uniprot
proteins
sequence_length
636
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Nucleus matrix. Nucleus speckle. Chromosome. Note=Nuclear, in a punctate pattern. Associated with euchromatic regions of the chromosomes. Colocalizes with the Ten-1 ICD form of TENM1 in foci associated with the nuclear matrix.
uniprot
proteins