Dlg1
entrez
25252
canonical
uniprot
Q62696
canonical
ensembl
ENSRNOG00000038597
resolver
ensp
ENSRNOP00000071898
resolver
ensp
ENSRNOP00000081862
resolver
ensp
ENSRNOP00000085582
resolver
ensp
ENSRNOP00000088710
resolver
ensp
ENSRNOP00000091905
resolver
ensp
ENSRNOP00000097997
resolver
enst
ENSRNOT00000078737
resolver
enst
ENSRNOT00000102386
resolver
enst
ENSRNOT00000108927
resolver
enst
ENSRNOT00000113230
resolver
genesymbol
Dlg1
resolver
genesymbol_syn
Dlgh1
resolver
uniprot
A0A0G2K1M2
resolver
uniprot
A0A8I5ZVT1
resolver
uniprot
A0A8I6A5M7
resolver
uniprot
A0A8I6GMS2
resolver
uniprot_entry
A0A0G2K1M2_RAT
resolver
uniprot_entry
A0A8I5ZVT1_RAT
resolver
uniprot_entry
A0A8I6A5M7_RAT
resolver
uniprot_entry
A0A8I6GMS2_RAT
resolver
uniprot_entry
DLG1_RAT
resolver
amino_acid_sequence
MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVISIFQSNLFQALIDIQEFYEVTLLDNPKCVDHSKQCEPVQPGNPWESGSLSSAAVTSESLPGGLSPPVEKYRYQDEEVLPSERISPQVPNEVLGPELVHVSEKSLSEIENVHGFVSHSHISPIKPTEAVPPSSPIVPVTPALPVPAESPVVLPSTPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEADVRDVTHSKAVEALKEAGSIVRLYVKRRKAFRKNHEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNSVCLEEVTHEEAVTALKNTSDFVYLKAAKPTSMYINDGYAPPDITNSSSQSVDNHVSPSSYLGQTPASPARYSPISKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLRETMMNSSVSSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRGDKGEIPDDMGSKGLKHVTSNASDSESSYHEYGCSKGGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRVNDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVRAVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTDEQARKTFERAVRLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGPYIWVPAKEKL
uniprot
proteins
function
FUNCTION: Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel (By similarity). During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:A0A8C0TYJ0, ECO:0000250|UniProtKB:Q12959, ECO:0000250|UniProtKB:Q811D0, ECO:0000269|PubMed:14960569, ECO:0000269|PubMed:15044483, ECO:0000269|PubMed:15504326, ECO:0000269|PubMed:19213956}.
uniprot
proteins
mass_dalton
100571
uniprot
proteins
mutagenesis
MUTAGEN 39; /note="S->A: No enrichment in postsynaptic density upon CaMK2 activation."; /evidence="ECO:0000269|PubMed:15044483"; MUTAGEN 39; /note="S->D: Localizes at the postsynaptic density."; /evidence="ECO:0000269|PubMed:15044483"; MUTAGEN 232; /note="S->A: No effect on association with GRIN2B."; /evidence="ECO:0000269|PubMed:12933808"; MUTAGEN 232; /note="S->D: Partial loss of association with GRIN2B."; /evidence="ECO:0000269|PubMed:12933808
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MAPK12 (By similarity). Phosphorylation of Ser-39 modulates transport to the plasma membrane (PubMed:15044483). Phosphorylation of Ser-232 regulates association with GRIN2A (PubMed:12933808). {ECO:0000250|UniProtKB:Q12959, ECO:0000269|PubMed:12933808, ECO:0000269|PubMed:15044483}.; PTM: Ubiquitinated; by MARCHF2 which results in its degradation. {ECO:0000250|UniProtKB:Q12959}.
uniprot
proteins
protein_family
MAGUK family
uniprot
proteins
pubmed
10629225
uniprot
proteins
pubmed
11865057
uniprot
proteins
pubmed
12933808
uniprot
proteins
pubmed
14597197
uniprot
proteins
pubmed
14960569
uniprot
proteins
pubmed
15044483
uniprot
proteins
pubmed
15504326
uniprot
proteins
pubmed
15951562
uniprot
proteins
pubmed
16495444
uniprot
proteins
pubmed
16630835
uniprot
proteins
pubmed
17980554
uniprot
proteins
pubmed
19118189
uniprot
proteins
pubmed
19213956
uniprot
proteins
pubmed
21119615
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7891172
uniprot
proteins
pubmed
9115257
uniprot
proteins
pubmed
9677374
uniprot
proteins
pubmed
9786987
uniprot
proteins
sequence_length
911
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19213956}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q12959}. Basolateral cell membrane {ECO:0000269|PubMed:11865057}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:10629225, ECO:0000269|PubMed:15044483}. Postsynaptic density {ECO:0000269|PubMed:15044483}. Synapse {ECO:0000269|PubMed:10629225}. Cell membrane, sarcolemma {ECO:0000269|PubMed:19213956}. Cell junction {ECO:0000269|PubMed:17980554}. Cytoplasm {ECO:0000250|UniProtKB:Q12959}. Apical cell membrane {ECO:0000250|UniProtKB:Q12959}. Note=Colocalizes with EPB41 at regions of intercellular contacts. Basolateral in epithelial cells (PubMed:11865057). May also associate with endoplasmic reticulum membranes (PubMed:10629225, PubMed:15044483). Mainly found in neurons soma, moderately found at postsynaptic densities (PubMed:15044483). {ECO:0000250|UniProtKB:Q12959, ECO:0000269|PubMed:10629225, ECO:0000269|PubMed:11865057, ECO:0000269|PubMed:15044483}.
uniprot
proteins