Tead2
entrez
21677
canonical
uniprot
P48301
canonical
ensembl
ENSMUSG00000030796
resolver
ensp
ENSMUSP00000033060
resolver
ensp
ENSMUSP00000103430
resolver
ensp
ENSMUSP00000103431
resolver
enst
ENSMUST00000033060
resolver
enst
ENSMUST00000097216
resolver
enst
ENSMUST00000107801
resolver
genesymbol
Tead2
resolver
genesymbol_syn
Etdf
resolver
genesymbol_syn
Etf
resolver
genesymbol_syn
Tef4
resolver
uniprot
F6TYA7
resolver
uniprot
Q3UPV9
resolver
uniprot
Q62297
resolver
uniprot
Q80UL2
resolver
uniprot_entry
F6TYA7_MOUSE
resolver
uniprot_entry
Q3UPV9_MOUSE
resolver
uniprot_entry
Q80UL2_MOUSE
resolver
uniprot_entry
TEAD2_MOUSE
resolver
uniprot_sec
Q62297
resolver
amino_acid_sequence
MGDPRTGAPLDDGGGWTGSEEGSEEGTGGSEGVGGDGSPDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSREIQSKLKDQVSKDKAFQTMATMSSAQLISAPSLQAKLGPSGPQATELFQFWSGSSGPPWNVPDVKPFSQAPFSVSLTPPASDLPGYEPPPALSPLPPPAPSPPAWQARALGTARLQLIEFSAFVEPPDAVDSFQRHLFVHISQQCPSPGAPPLESVDVRQIYDKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGPSAEEAGSSGGGGGFYGVSSQYESRELMTLTCSSKVCSFGKQVVEKVETERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQYHIYRLVRD
uniprot
proteins
function
FUNCTION: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction (By similarity). Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif. {ECO:0000250}.
uniprot
proteins
mass_dalton
49041
uniprot
proteins
pubmed
7629195
uniprot
proteins
pubmed
8702974
uniprot
proteins
pubmed
8812452
uniprot
proteins
pubmed
9169843
uniprot
proteins
sequence_length
445
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins