Pou4f2
entrez
18997
canonical
uniprot
Q63934
canonical
ensembl
ENSMUSG00000031688
resolver
ensp
ENSMUSP00000034115
resolver
genesymbol
Pou4f2
resolver
genesymbol_syn
Brn-3.2
resolver
genesymbol_syn
Brn3b
resolver
uniprot
Q63954
resolver
uniprot_entry
PO4F2_MOUSE
resolver
uniprot_sec
Q63954
resolver
amino_acid_sequence
MMMMSLNSKQAFSMPHAGSLHVEPKYSALHSASPGSSAPAAPSASSPSSSSNAGGGGGGGGGGGGGGRSSSSSSSGSGGSGGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDIVSQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHHHHQPHQALEGELLEHLSPGLALGAMAGPDGTVVSTPAHAPHMATMNPMHQAALSMAHAHGLPSHMGCMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEKSHREKLTKPELFNGAEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAGI
uniprot
proteins
function
FUNCTION: Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells (PubMed:10357904, PubMed:10414983, PubMed:11163266, PubMed:17668438, PubMed:25775587, PubMed:7904822, PubMed:8972215, PubMed:8995448). Functions either as activator or repressor by modulating the rate of target gene transcription through RNA polymerase II enzyme in a promoter-dependent manner (PubMed:10526314, PubMed:15733064, PubMed:17145718, PubMed:18368538, PubMed:7797498, PubMed:7852360, PubMed:7904822, PubMed:7935408, PubMed:8065921, PubMed:8662774, PubMed:9694219). Binds to the consensus octamer motif 5'-AT[A/T]A[T/A]T[A/T]A-3' of promoter of target genes (PubMed:10414983, PubMed:16152597, PubMed:17668438, PubMed:24643061, PubMed:7904822, PubMed:8290353, PubMed:9111308). Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation (PubMed:10357904, PubMed:25775587, PubMed:8632990). Binds to an octamer site to form a ternary complex with ISL1; cooperates positively with ISL1 and ISL2 to potentiate transcriptional activation of RGC target genes being involved in RGC fate commitment in the developing retina and RGC axon formation and pathfinding (PubMed:10357904, PubMed:11163266, PubMed:24643061, PubMed:25775587, PubMed:8972215, PubMed:8995448, PubMed:9261145). Inhibits DLX1 and DLX2 transcriptional activities preventing DLX1- and DLX2-mediated ability to promote amacrine cell fate specification (PubMed:21875655). In cooperation with TP53 potentiates transcriptional activation of BAX promoter activity increasing neuronal cell apoptosis (PubMed:17145718). Negatively regulates BAX promoter activity in the absence of TP53 (PubMed:17145718). Acts as a transcriptional coactivator via its interaction with the transcription factor ESR1 by enhancing its effect on estrogen response element (ERE)-containing promoter (PubMed:9448000). Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to an octamer motif (PubMed:7852360, PubMed:7935408, PubMed:8065921, PubMed:8537352, PubMed:8662774). Involved in TNFSF11-mediated terminal osteoclast differentiation (PubMed:17668438). {ECO:0000269|PubMed:10357904, ECO:0000269|PubMed:10414983, ECO:0000269|PubMed:10526314, ECO:0000269|PubMed:11163266, ECO:0000269|PubMed:15733064, ECO:0000269|PubMed:16152597, ECO:0000269|PubMed:17145718, ECO:0000269|PubMed:17668438, ECO:0000269|PubMed:18368538, ECO:0000269|PubMed:21875655, ECO:0000269|PubMed:24643061, ECO:0000269|PubMed:25775587, ECO:0000269|PubMed:7797498, ECO:0000269|PubMed:7852360, ECO:0000269|PubMed:7904822, ECO:0000269|PubMed:7935408, ECO:0000269|PubMed:8065921, ECO:0000269|PubMed:8290353, ECO:0000269|PubMed:8537352, ECO:0000269|PubMed:8632990, ECO:0000269|PubMed:8662774, ECO:0000269|PubMed:8972215, ECO:0000269|PubMed:8995448, ECO:0000269|PubMed:9111308, ECO:0000269|PubMed:9261145, ECO:0000269|PubMed:9448000, ECO:0000269|PubMed:9694219}.
uniprot
proteins
mass_dalton
43173
uniprot
proteins
mutagenesis
MUTAGEN 368; /note="I->V: Stimulates induction of neurite outgrowth and expression of synaptic genes. Abolishes the inhibitory effect on basal transcription and on gene activation by POU4F1."; /evidence="ECO:0000269|PubMed:8662774, ECO:0000269|PubMed:8972215, ECO:0000269|PubMed:8995448, ECO:0000269|PubMed:9261145, ECO:0000269|PubMed:9694219
uniprot
proteins
protein_family
Class-4 subfamily
uniprot
proteins
protein_family
POU transcription factor family
uniprot
proteins
pubmed
10357904
uniprot
proteins
pubmed
10414983
uniprot
proteins
pubmed
10526314
uniprot
proteins
pubmed
11163266
uniprot
proteins
pubmed
14726699
uniprot
proteins
pubmed
15733064
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16152597
uniprot
proteins
pubmed
17145718
uniprot
proteins
pubmed
17668438
uniprot
proteins
pubmed
18368538
uniprot
proteins
pubmed
21875655
uniprot
proteins
pubmed
22326227
uniprot
proteins
pubmed
23805044
uniprot
proteins
pubmed
24643061
uniprot
proteins
pubmed
25775587
uniprot
proteins
pubmed
7691107
uniprot
proteins
pubmed
7797498
uniprot
proteins
pubmed
7852360
uniprot
proteins
pubmed
7904822
uniprot
proteins
pubmed
7935408
uniprot
proteins
pubmed
8065921
uniprot
proteins
pubmed
8162704
uniprot
proteins
pubmed
8290353
uniprot
proteins
pubmed
8537352
uniprot
proteins
pubmed
8632990
uniprot
proteins
pubmed
8637595
uniprot
proteins
pubmed
8662774
uniprot
proteins
pubmed
8972215
uniprot
proteins
pubmed
8995448
uniprot
proteins
pubmed
9111308
uniprot
proteins
pubmed
9261145
uniprot
proteins
pubmed
9448000
uniprot
proteins
pubmed
9694219
uniprot
proteins
sequence_length
411
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17668438}. Nucleus speckle {ECO:0000250|UniProtKB:Q12837}. Cytoplasm {ECO:0000269|PubMed:17668438}.
uniprot
proteins