CS
entrez
1431
canonical
uniprot
O75390
canonical
ensembl
ENSG00000062485
resolver
ensp
ENSP00000342056
resolver
enst
ENST00000351328
resolver
genesymbol
CS
resolver
hgnc
HGNC:2422
resolver
uniprot
Q71UT9
resolver
uniprot
Q7KZH0
resolver
uniprot
Q96FZ8
resolver
uniprot
Q9BWN8
resolver
uniprot_entry
CISY_HUMAN
resolver
uniprot_sec
Q71UT9
resolver
uniprot_sec
Q7KZH0
resolver
uniprot_sec
Q96FZ8
resolver
uniprot_sec
Q9BWN8
resolver
amino_acid_sequence
MALLTAAARLLGTKNASCLVLAARHASASSTNLKDILADLIPKEQARIKTFRQQHGKTVVGQITVDMMYGGMRGMKGLVYETSVLDPDEGIRFRGFSIPECQKLLPKAKGGEEPLPEGLFWLLVTGHIPTEEQVSWLSKEWAKRAALPSHVVTMLDNFPTNLHPMSQLSAAVTALNSESNFARAYAQGISRTKYWELIYEDSMDLIAKLPCVAAKIYRNLYREGSGIGAIDSNLDWSHNFTNMLGYTDHQFTELTRLYLTIHSDHEGGNVSAHTSHLVGSALSDPYLSFAAAMNGLAGPLHGLANQEVLVWLTQLQKEVGKDVSDEKLRDYIWNTLNSGRVVPGYGHAVLRKTDPRYTCQREFALKHLPNDPMFKLVAQLYKIVPNVLLEQGKAKNPWPNVDAHSGVLLQYYGMTEMNYYTVLFGVSRALGVLAQLIWSRALGFPLERPKSMSTEGLMKFVDSKSG
uniprot
proteins
ec_number
2.3.3.1
uniprot
proteins
function
FUNCTION: Key enzyme of the Krebs tricarboxylic acid cycle which catalyzes the synthesis of citrate from acetyl coenzyme A and oxaloacetate. {ECO:0000305}.
uniprot
proteins
mass_dalton
51712
uniprot
proteins
mutagenesis
MUTAGEN 393; /note="K->R: Does not inhibit methylation."; /evidence="ECO:0000269|PubMed:28887308"; MUTAGEN 395; /note="K->R: Inhibits methylation."; /evidence="ECO:0000269|PubMed:28887308
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.
uniprot
proteins
post_translational_modification
PTM: Methylated (PubMed:28391595, PubMed:28887308). Trimethylation at Lys-395 by CSKMT decreases citrate synthase activity (PubMed:28887308). {ECO:0000269|PubMed:28391595, ECO:0000269|PubMed:28887308}.; PTM: In response to mitochondrial stress, the precursor protein is ubiquitinated by the SIFI complex in the cytoplasm before mitochondrial import, leading to its degradation (PubMed:38297121). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (PubMed:38297121). {ECO:0000269|PubMed:38297121}.
uniprot
proteins
protein_family
Citrate synthase family
uniprot
proteins
pubmed
12549038
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15242332
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28391595
uniprot
proteins
pubmed
28887308
uniprot
proteins
pubmed
31141475
uniprot
proteins
pubmed
38297121
uniprot
proteins
pubmed
9809442
uniprot
proteins
sequence_length
466
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:P00889}.
uniprot
proteins