Calhm6
entrez
294430
canonical
uniprot
Q561R8
canonical
ensembl
ENSRNOG00000037757
resolver
ensembl
ENSRNOG00055009614
resolver
ensembl
ENSRNOG00060002986
resolver
ensembl
ENSRNOG00065024653
resolver
ensp
ENSRNOP00000054134
resolver
ensp
ENSRNOP00055013067
resolver
ensp
ENSRNOP00060003534
resolver
ensp
ENSRNOP00065034623
resolver
enst
ENSRNOT00000057317
resolver
enst
ENSRNOT00055016260
resolver
enst
ENSRNOT00060004873
resolver
enst
ENSRNOT00065042321
resolver
genesymbol
Calhm6
resolver
genesymbol_syn
Fam26f
resolver
uniprot_entry
CAHM6_RAT
resolver
amino_acid_sequence
MEKFKAVLDLQIKHRSALGYGLVTLLTAGGEKIFSTVVFQCPCTATLNLTYGLVFLLVPALALFLLGYALSARTWRLLTGCCSRSASTRSSSGLRSTLVCAQVSAVAALAPLTWVAVALLGGSFYQCAVSGSTRLASYLCKDRNHSCIAKLPQVPCNKQEAEMQEILSQLKAQSQVLGWVLIAAVIFLLLVFKCVSRCFSPVSYLQLKFWEIYLEKEKQILQSQAAEHATQLARENIRSFFECSKPKECNTPSRKDWQQISALYTFNSKNQFYSMLHKYVSRKEVSSSLHSVEGDVVVPVLGFVDDAAMANTHGV
uniprot
proteins
function
FUNCTION: Pore-forming subunit of an ATP-permeable channel. In response to pathogen-derived and proinflammatory stimuli, relocates from intracellular compartments to NK-dendritic cell and NK-macrophage immune synapses where it mediates ATP efflux and NK cell activation involved in antimicrobial and antitumor responses (By similarity). May assemble to form gap junction channel-like structures with gating and ion conductance likely regulated by membrane lipids and voltage rather than by extracellular calcium levels (By similarity). {ECO:0000250|UniProtKB:Q5R3K3, ECO:0000250|UniProtKB:Q8C9E8}.
uniprot
proteins
mass_dalton
34730
uniprot
proteins
protein_family
CALHM family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
315
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8C9E8}; Multi-pass membrane protein {ECO:0000255}. Note=Recruited at immune synapses in response to pathogen-derived and proinflammatory stimuli. {ECO:0000250|UniProtKB:Q8C9E8}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..37; /note="Helical; Name=S1"; /evidence="ECO:0000250|UniProtKB:Q5R3K3"; TRANSMEM 47..68; /note="Helical; Name=S2"; /evidence="ECO:0000250|UniProtKB:Q5R3K3"; TRANSMEM 104..128; /note="Helical; Name=S3"; /evidence="ECO:0000250|UniProtKB:Q5R3K3"; TRANSMEM 170..192; /note="Helical; Name=S4"; /evidence="ECO:0000250|UniProtKB:Q5R3K3
uniprot
proteins