PFKFB2
entrez
5208
canonical
uniprot
O60825
canonical
ensembl
ENSG00000123836
resolver
ensp
ENSP00000356046
resolver
ensp
ENSP00000356047
resolver
ensp
ENSP00000576606
resolver
ensp
ENSP00000618319
resolver
ensp
ENSP00000675467
resolver
ensp
ENSP00000724338
resolver
genesymbol
PFKFB2
resolver
hgnc
HGNC:8873
resolver
uniprot
B0FLL2
resolver
uniprot
O60824
resolver
uniprot
Q5VVQ3
resolver
uniprot
Q5VVQ4
resolver
uniprot
Q9H3P1
resolver
uniprot_entry
B0FLL2_HUMAN
resolver
uniprot_entry
F262_HUMAN
resolver
uniprot_sec
O60824
resolver
uniprot_sec
Q5VVQ3
resolver
uniprot_sec
Q5VVQ4
resolver
uniprot_sec
Q9H3P1
resolver
activity_regulation
ACTIVITY REGULATION: Phosphorylation results in the activation of the kinase activity. {ECO:0000269|PubMed:11069105}.
uniprot
proteins
amino_acid_sequence
MSGASSSEQNNNSYETKTPNLRMSEKKCSWASYMTNSPTLIVMIGLPARGKTYVSKKLTRYLNWIGVPTKVFNLGVYRREAVKSYKSYDFFRHDNEEAMKIRKQCALVALEDVKAYLTEENGQIAVFDATNTTRERRDMILNFAEQNSFKVFFVESVCDDPDVIAANILEVKVSSPDYPERNRENVMEDFLKRIECYKVTYRPLDPDNYDKDLSFIKVINVGQRFLVNRVQDYIQSKIVYYLMNIHVQPRTIYLCRHGESEFNLLGKIGGDSGLSVRGKQFAQALRKFLEEQEITDLKVWTSQLKRTIQTAESLGVPYEQWKILNEIDAGVCEEMTYAEIEKRYPEEFALRDQEKYLYRYPGGESYQDLVQRLEPVIMELERQGNVLVISHQAVMRCLLAYFLDKGADELPYLRCPLHTIFKLTPVAYGCKVETIKLNVEAVNTHRDKPTNNFPKNQTPVRMRRNSFTPLSSSNTIRRPRNYSVGSRPLKPLSPLRAQDMQEGAD
uniprot
proteins
ec_number
2.7.1.105
uniprot
proteins
ec_number
3.1.3.46
uniprot
proteins
function
FUNCTION: Synthesis and degradation of fructose 2,6-bisphosphate. {ECO:0000269|PubMed:11069105}.
uniprot
proteins
mass_dalton
58477
uniprot
proteins
mutagenesis
MUTAGEN 466; /note="S->E: Constitutively active mutant that cannot be phosphorylated and further activated by AMPK."; /evidence="ECO:0000269|PubMed:11069105
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by AMPK stimulates activity. {ECO:0000269|PubMed:11069105}.
uniprot
proteins
protein_family
Phosphoglycerate mutase family
uniprot
proteins
pubmed
11069105
uniprot
proteins
pubmed
11374908
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
36402789
uniprot
proteins
pubmed
9652401
uniprot
proteins
sequence_length
505
uniprot
proteins