PACRG
entrez
135138
canonical
uniprot
Q96M98
canonical
ensembl
ENSG00000112530
resolver
ensp
ENSP00000337946
resolver
ensp
ENSP00000355854
resolver
ensp
ENSP00000355855
resolver
ensp
ENSP00000794051
resolver
genesymbol
PACRG
resolver
genesymbol_syn
GLUP
resolver
hgnc
HGNC:19152
resolver
uniprot
E1P5B5
resolver
uniprot
Q6IMB8
resolver
uniprot
Q8IZM1
resolver
uniprot
Q8NHP5
resolver
uniprot
Q9H1V9
resolver
uniprot_entry
PACRG_HUMAN
resolver
uniprot_sec
E1P5B5
resolver
uniprot_sec
Q6IMB8
resolver
uniprot_sec
Q8IZM1
resolver
uniprot_sec
Q8NHP5
resolver
uniprot_sec
Q9H1V9
resolver
amino_acid_sequence
MVAEKETLSLNKCPDKMPKRTKLLAQQPLPVHQPHSLVSEGFTVKAMMKNSVVRGPPAAGAFKERPTKPTAFRKFYERGDFPIALEHDSKGNKIAWKVEIEKLDYHHYLPLFFDGLCEMTFPYEFFARQGIHDMLEHGGNKILPVLPQLIIPIKNALNLRNRQVICVTLKVLQHLVVSAEMVGKALVPYYRQILPVLNIFKNMNGSYSLPRLECSGAIMARCNLDHLGSSDPPTSASQVAEIIVNSGDGIDYSQQKRENIGDLIQETLEAFERYGGENAFINIKYVVPTYESCLLN
uniprot
proteins
function
FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189). Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin) (PubMed:14532270). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited (PubMed:14532270). May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease (PubMed:14532270). {ECO:0000269|PubMed:14532270, ECO:0000269|PubMed:36191189}.
uniprot
proteins
mass_dalton
33342
uniprot
proteins
pubmed
12547187
uniprot
proteins
pubmed
14532270
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14737177
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
36191189
uniprot
proteins
sequence_length
296
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q9DAK2}.
uniprot
proteins