MTURN
entrez
222166
canonical
uniprot
Q8N3F0
canonical
ensembl
ENSG00000180354
resolver
ensp
ENSP00000324204
resolver
genesymbol
MTURN
resolver
genesymbol_syn
C7orf41
resolver
hgnc
HGNC:25457
resolver
uniprot
B8ZZW9
resolver
uniprot
Q8N791
resolver
uniprot
Q8N8M4
resolver
uniprot
Q8NEX2
resolver
uniprot_entry
MTURN_HUMAN
resolver
uniprot_sec
B8ZZW9
resolver
uniprot_sec
Q8N791
resolver
uniprot_sec
Q8N8M4
resolver
uniprot_sec
Q8NEX2
resolver
amino_acid_sequence
MDFQQLADVAEKWCSNTPFELIATEETERRMDFYADPGVSFYVLCPDNGCGDNFHVWSESEDCLPFLQLAQDYISSCGKKTLHEVLEKVFKSFRPLLGLPDADDDAFEEYSADVEEEEPEADHPQMGVSQQ
uniprot
proteins
function
FUNCTION: Promotes megakaryocyte differentiation by enhancing ERK and JNK signaling as well as up-regulating RUNX1 and FLI1 expression (PubMed:24681962). Represses NF-kappa-B transcriptional activity by inhibiting phosphorylation of RELA at 'Ser-536' (PubMed:24681962). May be involved in early neuronal development (By similarity). {ECO:0000250|UniProtKB:Q7ZX36, ECO:0000269|PubMed:24681962}.
uniprot
proteins
mass_dalton
14925
uniprot
proteins
mutagenesis
MUTAGEN 34; /note="Y->F: Loss of ability to promote megakaryocyte differentiation, enhance ERK and JNK signaling and up-regulate the expression of FLI1."; /evidence="ECO:0000269|PubMed:24681962
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Tyr-34 is essential for its ability to promote megakaryocyte differentiation. {ECO:0000269|PubMed:24681962}.
uniprot
proteins
protein_family
MTURN family
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
24681962
uniprot
proteins
sequence_length
131
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24681962}.
uniprot
proteins