Htr2a
entrez
15558
canonical
uniprot
P35363
canonical
ensembl
ENSMUSG00000034997
resolver
ensp
ENSMUSP00000047774
resolver
enst
ENSMUST00000036653
resolver
genesymbol
Htr2a
resolver
genesymbol_syn
Htr2
resolver
uniprot
Q543D4
resolver
uniprot_entry
5HT2A_MOUSE
resolver
uniprot_entry
Q543D4_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: G protein-coupled receptor activity is regulated by lipids: oleamide increases HTR2A-mediated activity. {ECO:0000250|UniProtKB:P28223}.
uniprot
proteins
amino_acid_sequence
MEILCEDNISLSSIPNSLMQLGDDSRLYPNDFNSRDANTSEASNWTIDAENRTNLSCEGYLPPTCLSILHLQEKNWSALLTTVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVAFFIPLTIMVITYFLTIKSLQKEATLCVSDLSTRAKLSSFSFLPQSSLSSEKLFQRSIHREPGSYAGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNENVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENRKPLQLILVNTIPTLAYKSSQLQVGQKKNSQEDAEPTANDCSMVTLGNQHSEEMCTDNIETVNEKVSCV
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:11960784, PubMed:16873667, PubMed:17270739, PubMed:18297054, PubMed:21645528, PubMed:23129762, PubMed:23346101). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). HTR2A is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively (By similarity). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:18297054). Affects neural activity, perception, cognition and mood (PubMed:18297054). Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances (PubMed:16873667, PubMed:17270739, PubMed:18297054, PubMed:23129762). Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction (PubMed:11960784, PubMed:23346101). {ECO:0000250|UniProtKB:P28223, ECO:0000269|PubMed:11960784, ECO:0000269|PubMed:16873667, ECO:0000269|PubMed:17270739, ECO:0000269|PubMed:18297054, ECO:0000269|PubMed:21645528, ECO:0000269|PubMed:23129762, ECO:0000269|PubMed:23346101}.
uniprot
proteins
mass_dalton
52842
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11960784
uniprot
proteins
pubmed
1333538
uniprot
proteins
pubmed
14988405
uniprot
proteins
pubmed
16873667
uniprot
proteins
pubmed
17270739
uniprot
proteins
pubmed
18297054
uniprot
proteins
pubmed
21645528
uniprot
proteins
pubmed
23129762
uniprot
proteins
pubmed
23346101
uniprot
proteins
sequence_length
471
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21645528}; Multi-pass membrane protein {ECO:0000305}. Cell projection, dendrite {ECO:0000269|PubMed:11960784}. Cell projection, axon {ECO:0000250|UniProtKB:P14842}. Cytoplasmic vesicle {ECO:0000269|PubMed:11960784}. Membrane, caveola {ECO:0000250|UniProtKB:P14842}. Presynapse {ECO:0000250|UniProtKB:P14842}.
uniprot
proteins
transmembrane_region
TRANSMEM 81..97; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P28223"; TRANSMEM 112..137; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P28223"; TRANSMEM 147..171; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P28223"; TRANSMEM 192..215; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P28223"; TRANSMEM 233..258; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P28223"; TRANSMEM 323..348; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P28223"; TRANSMEM 357..382; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P28223
uniprot
proteins