Pex19
entrez
19298
canonical
uniprot
Q8VCI5
canonical
ensembl
ENSMUSG00000003464
resolver
ensp
ENSMUSP00000075289
resolver
ensp
ENSMUSP00000106883
resolver
ensp
ENSMUSP00000200717
resolver
ensp
ENSMUSP00000200718
resolver
genesymbol
Pex19
resolver
genesymbol_syn
Pxf
resolver
uniprot
Q4FJU7
resolver
uniprot
Q8CEE1
resolver
uniprot
Q921H0
resolver
uniprot
Q9CZC1
resolver
uniprot
Q9QUQ1
resolver
uniprot_entry
PEX19_MOUSE
resolver
uniprot_sec
Q4FJU7
resolver
uniprot_sec
Q8CEE1
resolver
uniprot_sec
Q921H0
resolver
uniprot_sec
Q9CZC1
resolver
uniprot_sec
Q9QUQ1
resolver
amino_acid_sequence
MAAAEEGCGVGVEDDRELEELLESALDDFDKAKPSPEHAPTISAPDASGPQKRAPGDTAKDALFASQEKFFQELFDSELASQATAEFEKAMKELAEEEPHLVEQFQKLSEAAGRVGSDASSQQEFTSCLKETLSGLAKNATELQNSGMSEEELMKAMEGLGMDEGDGEASILPIMQSIMQNLLSKDVLYPSLKEITEKYPEWLQSHQDSTPPEQFEKYQQQHSVMVKICEQFEAETPTDSEATQRARFEAMLDLMQQLQALGHPPKELAGEMPPGLNFDLDALNLSGPPGANGEQCLIM
uniprot
proteins
function
FUNCTION: Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53. {ECO:0000250|UniProtKB:P40855}.
uniprot
proteins
mass_dalton
32733
uniprot
proteins
protein_family
Peroxin-19 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
299
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P40855}. Peroxisome membrane {ECO:0000250|UniProtKB:P40855}; Lipid-anchor {ECO:0000250|UniProtKB:P40855}; Cytoplasmic side {ECO:0000250|UniProtKB:P40855}. Note=Mainly cytoplasmic, some fraction membrane-associated to the outer surface of peroxisomes. {ECO:0000250|UniProtKB:P40855}.
uniprot
proteins