Chka
entrez
12660
canonical
uniprot
O54804
canonical
ensembl
ENSMUSG00000024843
resolver
ensp
ENSMUSP00000025760
resolver
ensp
ENSMUSP00000071933
resolver
ensp
ENSMUSP00000175179
resolver
genesymbol
Chka
resolver
genesymbol_syn
Chk
resolver
uniprot
G5E853
resolver
uniprot
Q8BPL3
resolver
uniprot
Q8BPW6
resolver
uniprot
Q9CXP3
resolver
uniprot
Q9QX56
resolver
uniprot_entry
CHKA_MOUSE
resolver
uniprot_sec
G5E853
resolver
uniprot_sec
Q8BPL3
resolver
uniprot_sec
Q8BPW6
resolver
uniprot_sec
Q9CXP3
resolver
uniprot_sec
Q9QX56
resolver
amino_acid_sequence
MKTKFCTGGEAEPSPLGLLLSCGGNAAPTPGVGQQRDAAGELESKQLGGRTQPLALPPPPPPPLPLPPPPSPPLADEQPEPRTRRRAYLWCKEFLPGAWRGLREDQFHISVIRGGLSNMLFQCSLPDSIASVGDEPRKVLLRLYGAILKMRSCNKEGSEQAQNENEFQGAEAMVLESVMFAILAERSLGPKLFGIFPQGRLEQFIPSRRLDTEELRLPDISAEIAEKMATFHGMKMPFNKEPKWLFGTMEKYLNQVLRLKFSREARVQQLHKILSYNLPLELENLRSLLQYTRSPVVFCHNDCQEGNILLLEGQENSERRKLMLIDFEYSSYNYRGFDIGNHFCEWMYDYTYEKYPFFRANIQKYPSRKQQLHFISSYLTTFQNDFESLSSEEQFATKEDMLLEVNRFALASHFLWGLWSIVQAKISSIEFGYMEYAQARFEAYFDQKRKLGV
uniprot
proteins
ec_number
2.7.1.32
uniprot
proteins
ec_number
2.7.1.82
uniprot
proteins
function
FUNCTION: Plays a key role in phospholipid biosynthesis by catalyzing the phosphorylation of free choline to phosphocholine, the first step in phosphatidylcholine biosynthesis. Also phosphorylates ethanolamine, thereby contributing to phosphatidylethanolamine biosynthesis. Has higher activity with choline. {ECO:0000250|UniProtKB:P35790}.; FUNCTION: [Isoform 1]: This isoform plays a key role in lipolysis of lipid droplets following glucose deprivation (By similarity). In response to glucose deprivation, phosphorylated by AMPK, promoting localization to lipid droplets (By similarity). Phosphorylation is followed by acetylation by KAT5, leading to dissociation of the homodimer into a monomer (By similarity). Monomeric CHKA isoform 1 is converted into a tyrosine-protein kinase, which phosphorylates lipid droplet structural proteins PLIN2 and PLIN3, leading to lipolysis of lipid droplets (By similarity). {ECO:0000250|UniProtKB:P35790}.
uniprot
proteins
mass_dalton
51985
uniprot
proteins
pathway_participation
PATHWAY: Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphocholine from choline: step 1/1. {ECO:0000250|UniProtKB:P35790}.; PATHWAY: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3. {ECO:0000250|UniProtKB:P35790}.
uniprot
proteins
post_translational_modification
PTM: [Isoform 1]: Phosphorylated at Ser-275 by AMPK in response to glucose deprivation, leading to localization to lipid droplets. {ECO:0000250|UniProtKB:P35790}.; PTM: [Isoform 1]: Acetylated by KAT5 at Lys-243 following phosphorylation by AMPK, leading to monomerization and conversion into a tyrosine-protein kinase. {ECO:0000250|UniProtKB:P35790}.
uniprot
proteins
protein_family
Choline/ethanolamine kinase family
uniprot
proteins
pubmed
10706593
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16490392
uniprot
proteins
pubmed
18029352
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9714798
uniprot
proteins
sequence_length
453
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P35790}.; SUBCELLULAR LOCATION: [Isoform 1]: Lipid droplet {ECO:0000250|UniProtKB:P35790}. Note=Isoform 1 localizes to lipid droplets following phosphorylation by AMPK. {ECO:0000250|UniProtKB:P35790}.
uniprot
proteins