CHCHD3
entrez
54927
canonical
uniprot
Q9NX63
canonical
ensembl
ENSG00000106554
resolver
ensp
ENSP00000262570
resolver
ensp
ENSP00000389297
resolver
ensp
ENSP00000770044
resolver
enst
ENST00000262570
resolver
enst
ENST00000448878
resolver
genesymbol
CHCHD3
resolver
genesymbol_syn
MIC19
resolver
genesymbol_syn
MINOS3
resolver
hgnc
HGNC:21906
resolver
uniprot
B7Z1X9
resolver
uniprot
C9JRZ6
resolver
uniprot_entry
B7Z1X9_HUMAN
resolver
uniprot_entry
C9JRZ6_HUMAN
resolver
uniprot_entry
MIC19_HUMAN
resolver
amino_acid_sequence
MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVSDEELKRRVAEELALEQAKKESEDQKRLKQAKELDRERAAANEQLTRAILRERICSEEERAKAKHLARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTEQYQKAAEEVEAKFKRYESHPVCADLQAKILQCYRENTHQTLKCSALATQYMHCVNHAKQSMLEKGG
uniprot
proteins
function
FUNCTION: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane (PubMed:25781180, PubMed:32567732, PubMed:33130824). Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:25781180, PubMed:32567732, PubMed:33130824). Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription (PubMed:22567091). {ECO:0000269|PubMed:22567091, ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:32567732, ECO:0000269|PubMed:33130824}.
uniprot
proteins
mass_dalton
26152
uniprot
proteins
protein_family
MICOS complex subunit Mic19 family
uniprot
proteins
protein_family
Metazoan Mic19 subfamily
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21081504
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22114354
uniprot
proteins
pubmed
22228767
uniprot
proteins
pubmed
22252321
uniprot
proteins
pubmed
22567091
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24687277
uniprot
proteins
pubmed
25255805
uniprot
proteins
pubmed
25781180
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
25997101
uniprot
proteins
pubmed
32567732
uniprot
proteins
pubmed
33130824
uniprot
proteins
pubmed
34344827
uniprot
proteins
sequence_length
227
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9CRB9}; Lipid-anchor {ECO:0000305}; Intermembrane side {ECO:0000250|UniProtKB:Q9CRB9}. Cytoplasm {ECO:0000269|PubMed:22567091}. Nucleus {ECO:0000269|PubMed:22567091}. Mitochondrion {ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:25997101}.
uniprot
proteins