Arpc5
entrez
67771
canonical
uniprot
Q9CPW4
canonical
ensembl
ENSMUSG00000008475
resolver
ensp
ENSMUSP00000076933
resolver
enst
ENSMUST00000077755
resolver
genesymbol
Arpc5
resolver
uniprot
Q3U9T3
resolver
uniprot
Q9D8E7
resolver
uniprot_entry
ARPC5_MOUSE
resolver
uniprot_sec
Q3U9T3
resolver
uniprot_sec
Q9D8E7
resolver
amino_acid_sequence
MSKNTVSSARFRKVDVDEYDENKFVDEEDGGDGQAGPDEGEVDSCLRQGNMTAALQAALKNPPINTKSQAVKDRAGSIVLKVLISFKANDIEKAVQSLDKNGVDLLMKYIYKGFESPSDNSSAVLLQWHEKALAAGGVGSIVRVLTARKTV
uniprot
proteins
function
FUNCTION: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). {ECO:0000250|UniProtKB:O15511}.
uniprot
proteins
mass_dalton
16288
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated by RNF128 with 'Lys-63'-linked chains, leading to proteasomal degradation. {ECO:0000250|UniProtKB:O15511}.
uniprot
proteins
protein_family
ARPC5 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
151
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O15511}. Cell projection {ECO:0000250|UniProtKB:O15511}. Nucleus {ECO:0000250|UniProtKB:O15511}.
uniprot
proteins