Nlrp6
entrez
101613
canonical
uniprot
Q91WS2
canonical
ensembl
ENSMUSG00000038745
resolver
ensp
ENSMUSP00000139357
resolver
genesymbol
Nlrp6
resolver
genesymbol_syn
Nalp6
resolver
genesymbol_syn
Navr
resolver
genesymbol_syn
Pypaf5
resolver
uniprot
C9W978
resolver
uniprot
F8UKQ6
resolver
uniprot
Q67EY0
resolver
uniprot
Q8K0L4
resolver
uniprot_entry
NLRP6_MOUSE
resolver
uniprot_sec
C9W978
resolver
uniprot_sec
F8UKQ6
resolver
uniprot_sec
Q67EY0
resolver
uniprot_sec
Q8K0L4
resolver
amino_acid_sequence
MDAAGASCSSVDAVARELLMATLEELSQEQLKRFRHKLRDAPLDGRSIPWGRLERSDAVDLVDKLIEFYEPVPAVEMTRQVLKRSDIRDVASRLKQQQLQKLGPTSVLLSVSAFKKKYREHVLRQHAKVKERNARSVKINKRFTKLLIAPGTGAVEDELLGPLGEPEPERARRSDTHTFNRLFRGNDEESSQPLTVVLQGPAGIGKTMAAKKILYDWAAGKLYHSQVDFAFFMPCGELLERPGKRSLADLVLDQCPDRAWPVKRILAQPNRLLFILDGADELPTLPSSEATPCKDPLEATSGLRVLSGLLSQELLPGARLLVTTRHAATGRLQGRLCSPQCAEIRGFSDKDKKKYFFKFFRDERKAERAYRFVKENETLFALCFVPFVCWIVCTVLQQQLELGRDLSRTSKTTTSVYLLFITSMLKSAGTNGPRVQGELRTLCRLAREGILDHHKAQFSEEDLEKLKLRGSQVQTIFLNKKEIPGVLKTEVTYQFIDQSFQEFLAALSYLLEAERTPGTPAGGVQKLLNSDAELRGHLALTTRFLFGLLNTEGLRDIGNHFGCVVPDHVKKDTLRWVQGQSHPKGPPVGAKKTAELEDIEDAEEEEEEEEDLNFGLELLYCLYETQEEDFVRQALSSLPEIVLERVRLTRMDLEVLNYCVQCCPDGQALRLVSCGLVAAKEKKKKKKSLVKRLKGSQSTKKQPPVSLLRPLCETMTTPKCHLSVLILSHCRLPDAVCRDLSEALKVAPALRELGLLQSRLTNTGLRLLCEGLAWPKCQVKTLRMQLPDLQEVINYLVIVLQQSPVLTTLDLSGCQLPGVIVEPLCAALKHPKCSLKTLSLTSVELSENSLRDLQAVKTSKPDLSIIYSK
uniprot
proteins
function
FUNCTION: Acts as the sensor component of the NLRP6 inflammasome, which mediates inflammasome activation in response to various pathogen-associated signals, leading to maturation and secretion of IL1B and IL18 (PubMed:21593405, PubMed:30392956, PubMed:32424362, PubMed:34678144). Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation (PubMed:30392956). Acts as a recognition receptor (PRR): recognizes and binds specific pathogens and other damage-associated signals, such as lipoteichoic acid (LTA), a cell-wall component of Gram-positive bacteria, or double stranded RNA (dsRNA) (PubMed:26494172, PubMed:30392956, PubMed:34678144). May also recognize and bind lipopolysaccharide (LPS), a major component of the outer membrane of Gram-negative bacteria; however, LPS is probably not a major activator of the NLRP6 inflammasome (PubMed:34678144). Following LTA- or dsRNA-binding, NLRP6 undergoes liquid-liquid phase separation (LLPS), enhancing multivalent interactions, an essential step for the formation of the NLRP6 inflammasome polymeric complex (PubMed:34678144). The NLRP6 inflammasome acts by promoting recruitment of effector pro-inflammatory caspases (CASP1 and/or CASP4) that catalyze maturation and secretion of IL1B and IL18 in the extracellular milieu (PubMed:30392956). The NLRP6 inflammasome plays a central role in the maintenance of epithelial integrity and host defense against microbial infections in the intestine (PubMed:21565393, PubMed:22763455, PubMed:23696660, PubMed:26638072, PubMed:28445725, PubMed:30392956). Required to restrict infection against Gram-positive bacteria by recognizing lipoteichoic acid (LTA), leading to recruitment of CASP4 and CASP1, and subsequent maturation and secretion of IL1B and IL18 (PubMed:30392956). Involved in intestinal antiviral innate immunity together with DHX15: recognizes and binds viral dsRNA to restrict infection by enteric viruses through the interferon pathway and GSDMD-dependent release of IL18 (PubMed:26494172, PubMed:34678144). Required to prevent infection by the apicomplexan parasite C.tyzzeri in enterocytes by promoting GSDMD-dependent release of IL18 (PubMed:33372132). The NLRP6 inflammasome may also regulate the gut microbiota composition by acting as a sensor of microbiota-associated metabolites to form a PYCARD/ASC-dependent inflammasome for downstream IL18 release and secretion of antimicrobial peptides (PubMed:21565393, PubMed:22763455, PubMed:26638072, PubMed:33617596). Its role in the regulation of the gut microbiota composition is however subject to discussion (PubMed:28801232, PubMed:29281815, PubMed:29281837). Essential for gut mucosal self-renewal and proliferation (PubMed:21543645, PubMed:21565393, PubMed:21593405). Regulate mucus secretion in an inflammasome- and autophagy-dependent manner to prevent invasion by enteric bacteria (PubMed:24581500, PubMed:27339979). During systemic bacterial infections, the NLRP6 inflammasome negatively regulates neutrophil recruitment and neutrophil extracellular traps (NETs) formation (PubMed:22763455, PubMed:30248149, PubMed:33230225, PubMed:33918100). May promote peripheral nerve recovery following injury via an inflammasome-independent mechanism (PubMed:26253422). {ECO:0000269|PubMed:21543645, ECO:0000269|PubMed:21565393, ECO:0000269|PubMed:21593405, ECO:0000269|PubMed:22763455, ECO:0000269|PubMed:23696660, ECO:0000269|PubMed:24581500, ECO:0000269|PubMed:26253422, ECO:0000269|PubMed:26494172, ECO:0000269|PubMed:26638072, ECO:0000269|PubMed:27339979, ECO:0000269|PubMed:28445725, ECO:0000269|PubMed:28801232, ECO:0000269|PubMed:29281815, ECO:0000269|PubMed:29281837, ECO:0000269|PubMed:30248149, ECO:0000269|PubMed:30392956, ECO:0000269|PubMed:32424362, ECO:0000269|PubMed:33230225, ECO:0000269|PubMed:33372132, ECO:0000269|PubMed:33617596, ECO:0000269|PubMed:33918100, ECO:0000269|PubMed:34678144}.
uniprot
proteins
mass_dalton
97402
uniprot
proteins
mutagenesis
MUTAGEN 170..173; /note="RARR->AAAA: Does not affect formation of liquid-liquid phase separation (LLPS)."; /evidence="ECO:0000269|PubMed:34678144"; MUTAGEN 350..354; /note="KDKKK->ADAAA: Impaired formation of liquid-liquid phase separation (LLPS), leading to reduced formation of the NLRP6 inflammasome and GSDMD-dependent release of IL18."; /evidence="ECO:0000269|PubMed:34678144
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated with 'Lys-63'-linked chains, promoting the interaction with PYCARD/ASC and formation of the NLRP6 inflammasome (PubMed:32424362). Deubiquitination by CYLD decreases the interaction with PYCARD/ASC (PubMed:32424362). {ECO:0000269|PubMed:32424362}.
uniprot
proteins
protein_family
NLRP family
uniprot
proteins
pubmed
12633874
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20923861
uniprot
proteins
pubmed
21543645
uniprot
proteins
pubmed
21565393
uniprot
proteins
pubmed
21593405
uniprot
proteins
pubmed
22763455
uniprot
proteins
pubmed
23470617
uniprot
proteins
pubmed
23696660
uniprot
proteins
pubmed
24581500
uniprot
proteins
pubmed
26253422
uniprot
proteins
pubmed
26494172
uniprot
proteins
pubmed
26638072
uniprot
proteins
pubmed
27339979
uniprot
proteins
pubmed
28445725
uniprot
proteins
pubmed
28801232
uniprot
proteins
pubmed
29281815
uniprot
proteins
pubmed
29281837
uniprot
proteins
pubmed
30248149
uniprot
proteins
pubmed
30392956
uniprot
proteins
pubmed
32424362
uniprot
proteins
pubmed
33230225
uniprot
proteins
pubmed
33372132
uniprot
proteins
pubmed
33617596
uniprot
proteins
pubmed
33918100
uniprot
proteins
pubmed
34678144
uniprot
proteins
sequence_length
869
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q63035}. Inflammasome {ECO:0000269|PubMed:30248149, ECO:0000269|PubMed:34678144}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000250|UniProtKB:Q63035}. Inflammasome {ECO:0000250|UniProtKB:P59044}. Cell membrane {ECO:0000250|UniProtKB:Q63035}. Nucleus membrane {ECO:0000250|UniProtKB:Q63035}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000250|UniProtKB:Q63035}. Cell membrane {ECO:0000250|UniProtKB:Q63035}. Note=Predominantly expressed in the cell membrane. {ECO:0000250|UniProtKB:Q63035}.
uniprot
proteins