Necab2
entrez
170928
canonical
uniprot
F1LQY6
canonical
ensembl
ENSRNOG00000015084
resolver
ensembl
ENSRNOG00060023849
resolver
ensp
ENSRNOP00000020341
resolver
ensp
ENSRNOP00000100370
resolver
ensp
ENSRNOP00060034452
resolver
enst
ENSRNOT00000020341
resolver
enst
ENSRNOT00000148837
resolver
enst
ENSRNOT00060041575
resolver
genesymbol
Necab2
resolver
genesymbol_syn
Efcbp2
resolver
uniprot
A0A5H1ZRU5
resolver
uniprot
Q9ESB4
resolver
uniprot_entry
A0A5H1ZRU5_RAT
resolver
uniprot_entry
NECA2_RAT
resolver
uniprot_sec
Q9ESB4
resolver
amino_acid_sequence
MCERAARLCRAGAHRLLREPPPQGRALGGLLRWVGARMGEPRAPLVPDIPAADPDPGPAAPRGGTAVILDIFRRADKNDDGKLSLEEFQLFFADGVLNEKELEGLFHTIDSDNTNHVDTKELCDYFVEHMGDYEDVLASLETLNHSVLKAMGYTKKVYEGGNNVDQFVTRFLLKETANQIQSLLSSVESAVEAIEEQTSQIRQDHCKPSPGVNESRYGGPTPPYIPNHKLVVPEPVKSLPVAIGEPKEEGLEVQISRLAELIGRLESKTLSFDLQQRLSDEEGTNMYLQLVRQEMAVCPEQLGEFLDSLRQYLRSTAEERNCFHVAAVRMADGLTFVIYEFWETEEEWKRHLQSPVCKAFRHVKVDTLSQPEALSQISVPAAWCTSGRD
uniprot
proteins
function
FUNCTION: May act as a signaling scaffold protein that senses intracellular calcium. Can modulate ligand-induced internalization of ADORA2A and coupling efficiency of mGluR5/GRM5; for both receptors may regulate signaling activity such as promoting MAPK1/3 (ERK1/2) activation. {ECO:0000250|UniProtKB:Q7Z6G3}.
uniprot
proteins
mass_dalton
43526
uniprot
proteins
pubmed
12044471
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
17689978
uniprot
proteins
pubmed
19694902
uniprot
proteins
pubmed
26843217
uniprot
proteins
sequence_length
389
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17689978}. Cell projection, dendrite {ECO:0000269|PubMed:17689978}. Cell projection, axon {ECO:0000269|PubMed:17689978}. Cell membrane {ECO:0000250|UniProtKB:Q7Z6G3}. Note=Colocalizes with ADORA2A and/or mGluR5/GRM5 at the plasma membrane (By similarity). Found in neuronal somata (PubMed:26843217). Detected in the cytoplasm of striatal neurons, at postsynaptic sites, filling dendritic shafts and spines, and at presynaptic sites, filling axon terminals (PubMed:17689978). {ECO:0000250|UniProtKB:Q7Z6G3, ECO:0000269|PubMed:17689978, ECO:0000269|PubMed:26843217}.
uniprot
proteins