Ccdc62
entrez
208908
canonical
uniprot
E9PVD1
canonical
ensembl
ENSMUSG00000061882
resolver
ensp
ENSMUSP00000091878
resolver
enst
ENSMUST00000094320
resolver
genesymbol
Ccdc62
resolver
uniprot
F6WEA5
resolver
uniprot_entry
CCD62_MOUSE
resolver
uniprot_sec
F6WEA5
resolver
amino_acid_sequence
MRSSEGAPSWAVALPPPLRPCAYGVSEVTRCWHQLSLGAGESSMNPSATLYRRQNIGSEVETSTIEKQRKELQLLIGELKDRDKELNDMVAVHQRQLLSWEEDRQKVLTLEERCSKLEGELHKRTDIIKSLMKKVKTLESNQAECQTALQKTQQQLQEMAQKATHSTLLSEDLEARNENLSSTLVDLSAQVGQLQAREQALTTMIKLKDKDIIEAVNHISDCSGKFKLLEHALRDAKMAETCVVREKQDYKQKLKALRIEVNKLKEDLNEKTTENNEQREEIIRLKQEKSCLHDELIFTVEREKRKDELLDIAKSKQDRTNSELQNLRQIYVKQQSDLQFLNFNIESSQELIQIHGLKMEEPKALECSKDMCLSDLDNNYPKIDIKRERNQKSLVKDQTFEVMLAQHNGSDKSSCDACREKKLQVNTALGEKSVIALSSLFTKDLLDKQKSWSLGGKIQTEPENKVTLCKVHAKSPKCDGVGLPTEEKQLSETSVSLSDEKQWHDINVYLGLSSCSKQPDRLDGDGHDRTGTSEVSCCTPNVVCIGDNDLSESKCCHPSNIIIEAPGHMTDTEWMNIFKPSRAQRIVRHKTMCTCSRSVSAMKYNSSASELIGMQPSQCVGSLKSAEREEESAALPDRRTSANEKDDFSPTSKLQRLLAESRQMVTDLELSTLLPISCENLNRSKLEVSEEPDEKTTLVSH
uniprot
proteins
function
FUNCTION: Nuclear receptor coactivator that can enhance preferentially estrogen receptors ESR1 and ESR2 transactivation. Also modulates progesterone/PGR, glucocorticoid/NR3C1 and androgen/AR receptors transactivation, although at lower level; little effect on vitamin D receptor/VDR (By similarity). Required for normal spermiogenesis (PubMed:28339613). It probably plays a role in acrosome formation (PubMed:28339613). {ECO:0000250, ECO:0000269|PubMed:28339613}.
uniprot
proteins
mass_dalton
79317
uniprot
proteins
mutagenesis
MUTAGEN 284..701; /note="Missing: Loss of interaction with GOPC. Does not localize to the acrosome. Homozygous mutant mice are infertile and show deformed sperm with reduced motility."; /evidence="ECO:0000269|PubMed:28339613
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
28339613
uniprot
proteins
sequence_length
701
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:28339613}. Note=Mainly nuclear. {ECO:0000250}.
uniprot
proteins