Cox7c
entrez
100188937
canonical
uniprot
P80432
canonical
ensembl
ENSRNOG00000030237
resolver
ensembl
ENSRNOG00055004061
resolver
ensembl
ENSRNOG00060000738
resolver
ensembl
ENSRNOG00065005545
resolver
ensp
ENSRNOP00000049222
resolver
ensp
ENSRNOP00055004963
resolver
ensp
ENSRNOP00060000211
resolver
ensp
ENSRNOP00065005762
resolver
enst
ENSRNOT00000051895
resolver
enst
ENSRNOT00055006481
resolver
enst
ENSRNOT00060000864
resolver
enst
ENSRNOT00065008226
resolver
genesymbol
Cox7c
resolver
genesymbol_syn
Cox7c1
resolver
uniprot
B2RYT3
resolver
uniprot_entry
COX7C_RAT
resolver
uniprot_sec
B2RYT3
resolver
amino_acid_sequence
MLGQSIRRFTTSVVRRSHYEEGPGKNLPFSVENKWRLLLMMTVYFGSGFAAPFFIVRHQLLKK
uniprot
proteins
function
FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P04039}.
uniprot
proteins
mass_dalton
7375
uniprot
proteins
pathway_participation
PATHWAY: Energy metabolism; oxidative phosphorylation. {ECO:0000250|UniProtKB:P04039}.
uniprot
proteins
protein_family
Cytochrome c oxidase VIIc family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7601105
uniprot
proteins
sequence_length
63
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00430}; Single-pass membrane protein {ECO:0000250|UniProtKB:P00430}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..60; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P00430
uniprot
proteins