Pcdhb6
entrez
93877
canonical
uniprot
Q91XZ4
canonical
ensembl
ENSMUSG00000051678
resolver
ensp
ENSMUSP00000058592
resolver
enst
ENSMUST00000061717
resolver
genesymbol
Pcdhb6
resolver
uniprot_entry
PCDB6_MOUSE
resolver
amino_acid_sequence
METTLAKTPEKRQVVFLAILLLLWEAGSEAIRYSIPEETESGYLVAHLAKDLGFRVGELATRRARIHHRGNKELLQLDVETGNLLLKEKPDREALCGATEPCVLHFQIILENPVQFFQTELQLTDINDHSPEFPDTEMLLKIQESTQPATVFLLKAAQDSDIGSNAVQNYTVSPNLHFHVVTLSRSDGRKYPELVLDRALDREEQPELTLILTALDGGAPPKSGTTTVRIEVVDINDNAPEFVQSLYSVEVPENSPLDALVVTVSARDLDAGIHGNVAYSLFQGGGGPQPFVIDEITGEIRLKGALDFEATSYYTMEIVATDSGGLSGKCTVAIQVLDVNDNAPKLTISSLTSSIPENAPEAVVAVFSVSDPDSGDNGRMVCSIQNELPFLLKPTFENYYTLAAEGPLDREIREEYNITIIVSDLGTPRLTTQHTITVQVVDINDNAPAFTQTSYTMFVHENNNPALHIGTISATDSDSGSNAHITYSLLPPHDLQLSLASLVSINADNGQLFALRAMDYEALQAFEFHVVARDGGSPALSSQALVRVVVLDDNDNAPFILYPMQNASAPCTELLPRAAEPGYLVTKVVAVDSDSGQNAWLSFQLLKATEPGLFSVWAHNGEVRTTRLLSERDVPKHRLLLLVKDNGEPPRSASVTLHVLLVDGFSQPYLPLPEVQHDSSQDEDMLTLYLVIALASVSSLFLLSVLLFVGVRLCRRVREASLGACSVPEGHFSGHLVDVSGMGTLSQSYQYEVCLSGDSGTTDFKFLNHYSQ
uniprot
proteins
function
FUNCTION: Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination (PubMed:27161523). Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain (PubMed:27161523). {ECO:0000269|PubMed:27161523}.
uniprot
proteins
mass_dalton
84280
uniprot
proteins
mutagenesis
MUTAGEN 67; /note="H->V: Changed homophilic interaction, being unable to interact with the wild-type protein but able to bind itself;when associated with D-69 and R-368."; /evidence="ECO:0000269|PubMed:27161523"; MUTAGEN 69; /note="R->D: Changed homophilic interaction, being unable to interact with the wild-type protein but able to bind itself;when associated with V-67 and R-368."; /evidence="ECO:0000269|PubMed:27161523"; MUTAGEN 141; /note="K->E: No effect on homophilic interaction. Changed homophilic interaction, being unable to interact with the wild-type protein but able to bind itself; when associated with R-323."; /evidence="ECO:0000269|PubMed:27161523"; MUTAGEN 143; /note="Q->P: Changed homophilic interaction; when associated with F-326."; /evidence="ECO:0000269|PubMed:27161523"; MUTAGEN 145; /note="S->I: Changed homophilic interaction, being unable to interact with the wild-type protein but able to bind itself."; /evidence="ECO:0000269|PubMed:27161523"; MUTAGEN 185; /note="R->N: No effect on homophilic interaction. Changed homophilic interaction, being unable to interact with the wild-type protein but able to bind itself; when associated with K-317."; /evidence="ECO:0000269|PubMed:27161523"; MUTAGEN 317; /note="E->K: Changed homophilic interaction, being unable to interact with the wild-type protein but able to bind itself; when associated with N-185."; /evidence="ECO:0000269|PubMed:27161523"; MUTAGEN 323; /note="S->R: Changed homophilic interaction, being unable to interact with the wild-type protein but able to bind itself; when associated with E-141."; /evidence="ECO:0000269|PubMed:27161523"; MUTAGEN 326; /note="L->F: No effect on homophilic interaction. Changed homophilic interaction; when associated with P-143."; /evidence="ECO:0000269|PubMed:27161523"; MUTAGEN 368; /note="S->R: No effect on homophilic interaction. Changed homophilic interaction, being unable to interact with the wild-type protein but able to bind itself; when associated with V-67 and D-69."; /evidence="ECO:0000269|PubMed:27161523
uniprot
proteins
pubmed
11230163
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
27161523
uniprot
proteins
sequence_length
772
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27161523}; Single-pass type I membrane protein {ECO:0000269|PubMed:27161523}.
uniprot
proteins
transmembrane_region
TRANSMEM 691..711; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins