Slc6a20
entrez
113918
canonical
uniprot
Q64093
canonical
ensembl
ENSRNOG00000068642
resolver
ensp
ENSRNOP00000007467
resolver
enst
ENSRNOT00000007467
resolver
genesymbol
Slc6a20
resolver
genesymbol
Slc6a20a
resolver
genesymbol_syn
Sit1
resolver
genesymbol_syn
Slc6a20
resolver
genesymbol_syn
Xtrp3
resolver
uniprot
G3V6Q4
resolver
uniprot_entry
G3V6Q4_RAT
resolver
uniprot_entry
S6A20_RAT
resolver
amino_acid_sequence
MRLAIKRRASRGQRPGPDEKRARDMEKARPQWGNPLQFVFACISYAVGLGNVWRFPYLCQMYGGGSFLVPYLIMLIVEGMPLLYLELAVGQRMRQGSIGAWRTISPYLSGVGVASVVVSFFLSMYYNVINAWGFWYLFHSFQDPLPWSVCPLNSNRTGYDEECEKASSTQYFWYRKTLNISPSIQENGGVQWEPALCLTLAWLMVYLCILRGTESTGKVVYFTALMPYCVLIIYLVRGLTLHGATNGLMYMFTPKIEQLANPKAWINAATQIFFSLGLGFGSLIAFASYNEPSNDCQKHAVIVSVINSSTSIFASIVTFSIYGFKATFNYENCLNKVILLLTNSFDLEDGFLTASNLEEVKDYLASTYPNKYSEVFPHIRNCSLESELNTAVQGTGLAFIVYAEAIKNMEVSQLWSVLYFFMLLMLGMGSMLGNTAAILTPLTDSKVISSYLPKEAISGLVCLINCAVGMVFTMEAGNYWFDIFNDYAATLSLLLIVLVETIAVCYVYGLRRFESDLRAMTGRPLNWYWKAMWAFVSPLLIIGLFIFYLSDYILTGTLQYQAWDATQGQLVTKDYPPHALAVIGLLVASSTMCIPLVALGTFIRNRLKRGGSSPVA
uniprot
proteins
function
FUNCTION: Mediates the Na(+)- and Cl(-)-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids (PubMed:15632147). Also transports glycine, regulates proline and glycine homeostasis in the brain playing a role in the modulation of NMDAR currents (By similarity). {ECO:0000250|UniProtKB:Q8VDB9, ECO:0000269|PubMed:15632147}.
uniprot
proteins
mass_dalton
68971
uniprot
proteins
protein_family
SLC6A20 subfamily
uniprot
proteins
protein_family
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
uniprot
proteins
pubmed
15632147
uniprot
proteins
pubmed
8001687
uniprot
proteins
sequence_length
616
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q8VDB9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8VDB9}. Note=Located in the apical brush border membrane of kidney proximal tubule cells and in the apical membrane of enterocytes lining the intestinal villi. {ECO:0000250|UniProtKB:Q8VDB9}.
uniprot
proteins
transmembrane_region
TRANSMEM 38..58; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 67..87; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 104..124; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 190..210; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 219..239; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 266..286; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 301..321; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 414..434; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 456..476; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 490..510; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 534..554; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 579..599; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins