Il1rap
entrez
25466
canonical
uniprot
Q63621
canonical
ensembl
ENSRNOG00000001928
resolver
ensp
ENSRNOP00000002645
resolver
ensp
ENSRNOP00000051260
resolver
ensp
ENSRNOP00000090112
resolver
enst
ENSRNOT00000043498
resolver
enst
ENSRNOT00000105096
resolver
genesymbol
Il1rap
resolver
genesymbol_syn
Il1racpb
resolver
uniprot
A0A8I6ACY6
resolver
uniprot
A0ACM8QJW3
resolver
uniprot
D1M8S3
resolver
uniprot
F1LRE8
resolver
uniprot_entry
A0A8I6ACY6_RAT
resolver
uniprot_entry
A0ACM8QJW3_RAT
resolver
uniprot_entry
D1M8S3_RAT
resolver
uniprot_entry
IL1AP_RAT
resolver
uniprot_sec
F1LRE8
resolver
amino_acid_sequence
MGLPWCLMSLFFCGILQSHASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKYNYSTAHSSGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMRLPVHRLYIEQGIHNITCPNVDGYFPSSVKPSVTWYKGCTEIVNFHNVQPKGMNLSFFIPLVSNNGNYTCVVTYLENGRLFHLTRTMTVKVVGSPKDAVPPHIYSPNDRVVYEKEPGEELVIPCKVYFSFIMDSHNEIWWTIDGKKPDDVPVDITIIESVSYSSTEDETRTQILSIKKVTPEDLKRNYVCHARNAEGEAEQAAKVKQKVIPPRYTVELACGFGATVFLVVVLIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNAEEEEFVLLTLRGVLENEFGYKLCIFDRDSFPGGIVTDETLSFIQKSRRLLVVLSPNYVLQGTQALLELKAGLENMASRGNINVILVQYKAVKDLKVKELKRAKSVLTVIKWKGEKSKYPQGRFWKQLQVAMPVKKSPRWSSSDKQGLSYSSLKNV
uniprot
proteins
ec_number
3.2.2.6
uniprot
proteins
function
FUNCTION: Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system (By similarity). Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (By similarity). {ECO:0000250|UniProtKB:Q61730, ECO:0000250|UniProtKB:Q9NPH3}.
uniprot
proteins
mass_dalton
65599
uniprot
proteins
protein_family
Interleukin-1 receptor family
uniprot
proteins
pubmed
8964912
uniprot
proteins
sequence_length
570
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 368..388; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins