APLNR
entrez
187
canonical
uniprot
P35414
canonical
ensembl
ENSG00000134817
resolver
ensp
ENSP00000257254
resolver
ensp
ENSP00000475344
resolver
enst
ENST00000257254
resolver
enst
ENST00000606794
resolver
genesymbol
APLNR
resolver
genesymbol_syn
AGTRL1
resolver
genesymbol_syn
APJ
resolver
hgnc
HGNC:339
resolver
uniprot
B2RDH3
resolver
uniprot
B3KQN4
resolver
uniprot_entry
APJ_HUMAN
resolver
uniprot_entry
B2RDH3_HUMAN
resolver
uniprot_entry
B3KQN4_HUMAN
resolver
amino_acid_sequence
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for peptide hormones apelin (APLN) and apelin receptor early endogenous ligand (APELA/ELA), that plays a role in the regulation of normal cardiovascular function and fluid homeostasis (PubMed:11090199, PubMed:22810587, PubMed:25639753, PubMed:28137936, PubMed:35817871, PubMed:38428423). When acting as apelin receptor, activates both G(i) protein pathway that inhibits adenylate cyclase activity, and the beta-arrestin pathway that promotes internalization of the receptor (PubMed:11090199, PubMed:25639753, PubMed:28137936, PubMed:35817871, PubMed:38428423). APLNR/APJ also functions as mechanoreceptor that is activated by pathological stimuli in a G protein-independent fashion to induce beta-arrestin signaling, hence eliciting cardiac hypertrophy (PubMed:22810587, PubMed:38428423). However, the presence of apelin ligand blunts cardiac hypertrophic induction from APLNR/APJ on response to pathological stimuli (PubMed:22810587, PubMed:38428423). Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a APELA receptor (By similarity). May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity). Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (By similarity). Also plays a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure (PubMed:25639753, PubMed:28137936). {ECO:0000250|UniProtKB:Q7SZP9, ECO:0000250|UniProtKB:Q9WV08, ECO:0000269|PubMed:11090199, ECO:0000269|PubMed:22810587, ECO:0000269|PubMed:25639753, ECO:0000269|PubMed:28137936, ECO:0000269|PubMed:35817871, ECO:0000269|PubMed:38428423}.; FUNCTION: (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia (PubMed:11090199). {ECO:0000269|PubMed:11090199}.
uniprot
proteins
mass_dalton
42660
uniprot
proteins
mutagenesis
MUTAGEN 19; /note="C->A: Decreased APLN/apelin-13 potency."; /evidence="ECO:0000269|PubMed:38428423"; MUTAGEN 35; /note="Y->A: Decreased APLN/apelin-13 potency. Decreased G(i) and beta-arresting signalings after APLN/apelin-13 induction."; /evidence="ECO:0000269|PubMed:38428423"; MUTAGEN 46; /note="N->A: Loss of beta-arrestin recruitment after APLN/apelin-13 induction. Small decrease in G(i) signaling after APLN/apelin-13 induction."; /evidence="ECO:0000269|PubMed:38428423"; MUTAGEN 85; /note="W->A: Loss of APELA signaling. Loss of APLN/apelin-13 signaling."; /evidence="ECO:0000269|PubMed:35817871, ECO:0000269|PubMed:38428423"; MUTAGEN 88; /note="Y->A: Decreased APELA potency. No change in APLN/apelin-13 potency."; /evidence="ECO:0000269|PubMed:35817871"; MUTAGEN 93; /note="Y->A: Decreased APELA potency. No change in APLN/apelin-13 potency."; /evidence="ECO:0000269|PubMed:35817871"; MUTAGEN 97; /note="F->A: Decreased protein expression level and cAMP-dependent pathway. Decreased protein expression level and cAMP-dependent pathway; when associated with A-98, A-99, A-100 and A-101."; /evidence="ECO:0000269|PubMed:35817871"; MUTAGEN 98; /note="G->A: Decreased protein expression level. Decreased protein expression level; when associated with A-97, A-99, A-100 and A-101."; /evidence="ECO:0000269|PubMed:35817871"; MUTAGEN 99; /note="T->A: No change in protein expression level. Decreased protein expression level; when associated with A-97, A-98, A-100 and A-101."; /evidence="ECO:0000269|PubMed:35817871"; MUTAGEN 100; /note="F->A: No change in protein expression level. Decreased protein expression level; when associated with A-97, A-98, A-99 and A-101."; /evidence="ECO:0000269|PubMed:35817871"; MUTAGEN 101; /note="F->A: Decreased homodimerization, no change in APELA potency, increased G protein and beta-arrestin signaling pathways. Decreased protein expression level; when associated with A-97, A-98, A-99 and A-100."; /evidence="ECO:0000269|PubMed:35817871"; MUTAGEN 109; /note="I->A: Strong decrease in beta-arresting signaling after APLN/apelin-13 induction. No change in G(i) signaling after APLN/apelin-13 induction."; /evidence="ECO:0000269|PubMed:38428423"; MUTAGEN 110; /note="F->A: No change in APELA potency. No change in APLN/apelin-13 potency. Decreased G(i) signaling and no change in beta-arresting signaling after APLN/apelin-13 induction."; /evidence="ECO:0000269|PubMed:35817871"; MUTAGEN 116; /note="S->A: Small decrease in G(i) signaling after APLN/apelin-13 induction. Decreased beta-arresting signaling after APLN/apelin-13 induction."; /evidence="ECO:0000269|PubMed:38428423"; MUTAGEN 168; /note="R->A: Loss of APELA signaling. Loss of APELA signaling."; /evidence="ECO:0000269|PubMed:35817871, ECO:0000269|PubMed:38428423"; MUTAGEN 173; /note="L->A: Decreased APELA potency. No change in APLN/apelin-13 potency."; /evidence="ECO:0000269|PubMed:35817871"; MUTAGEN 183; /note="M->A: Decreased APELA potency. No change in APLN/apelin-13 potency."; /evidence="ECO:0000269|PubMed:35817871"; MUTAGEN 185; /note="Y->A: Decreased APLN/apelin-13 potency."; /evidence="ECO:0000269|PubMed:38428423"; MUTAGEN 268; /note="K->A: Strong decrease in beta-arresting signaling after APLN/apelin-13 induction. No change in G(i) signaling after APLN/apelin-13 induction."; /evidence="ECO:0000269|PubMed:38428423"; MUTAGEN 271; /note="Y->A: Decreased APLN/apelin-13 potency."; /evidence="ECO:0000269|PubMed:38428423"; MUTAGEN 299; /note="Y->A: Decreased G(i) signalingafter APLN/apelin-13 induction. No change in beta-arresting signaling after APLN/apelin-13 induction."; /evidence="ECO:0000269|PubMed:38428423"; MUTAGEN 302; /note="S->A: No change in G(i) signaling after APLN/apelin-13 induction. Decreased beta-arresting signaling after APLN/apelin-13 induction."; /evidence="ECO:0000269|PubMed:38428423
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11090199
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22810587
uniprot
proteins
pubmed
25639753
uniprot
proteins
pubmed
28137936
uniprot
proteins
pubmed
35817871
uniprot
proteins
pubmed
38428423
uniprot
proteins
pubmed
8294032
uniprot
proteins
sequence_length
380
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25639753, ECO:0000269|PubMed:35817871, ECO:0000269|PubMed:38428423}. Note=After exposure to apelin (APLN), internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane (By similarity). After exposure to apelin receptor early endogenous ligand (APELA), internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane (PubMed:25639753). {ECO:0000250|UniProtKB:Q9JHG3, ECO:0000269|PubMed:25639753}.
uniprot
proteins
transmembrane_region
TRANSMEM 31..54; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:35817871, ECO:0007744|PDB:7W0O"; TRANSMEM 65..86; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:35817871, ECO:0007744|PDB:7W0O"; TRANSMEM 100..125; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:35817871, ECO:0007744|PDB:7W0O"; TRANSMEM 147..164; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:35817871, ECO:0007744|PDB:7W0O"; TRANSMEM 199..223; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:35817871, ECO:0007744|PDB:7W0O"; TRANSMEM 247..270; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:35817871, ECO:0007744|PDB:7W0O"; TRANSMEM 290..312; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:35817871, ECO:0007744|PDB:7W0O
uniprot
proteins