Mdh2
entrez
17448
canonical
uniprot
P08249
canonical
ensembl
ENSMUSG00000019179
resolver
ensp
ENSMUSP00000019323
resolver
enst
ENSMUST00000019323
resolver
genesymbol
Mdh2
resolver
genesymbol_syn
Mor1
resolver
uniprot
Q0QF44
resolver
uniprot
Q8CF79
resolver
uniprot
Q8R1P0
resolver
uniprot_entry
MDHM_MOUSE
resolver
uniprot_sec
Q0QF44
resolver
uniprot_sec
Q8CF79
resolver
uniprot_sec
Q8R1P0
resolver
activity_regulation
ACTIVITY REGULATION: Enzyme activity is enhanced by acetylation. {ECO:0000250|UniProtKB:P40926}.
uniprot
proteins
amino_acid_sequence
MLSALARPAGAALRRSFSTSAQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETRANVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPEAMVCIIANPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANTFVAELKGLDPARVNVPVIGGHAGKTIIPLISQCTPKVDFPQDQLATLTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVQSKETECTYFSTPLLLGKKGLEKNLGIGKITPFEEKMIAEAIPELKASIKKGEDFVKNMK
uniprot
proteins
ec_number
1.1.1.37
uniprot
proteins
function
FUNCTION: Mitochondrial malate dehydrogenase that catalyzes the reversible conversion of malate to oxaloacetate using NAD(+) as a cofactor. Plays a central role in the tricarboxylic acid (TCA) cycle contributing to cellular respiration and energy production via the mitochondrial electron transport chain (By similarity). Also participates in the malate-aspartate NADH shuttle, facilitating transfer of reducing equivalents between cytosol and mitochondria to maintain redox balance (NAD(+)/NADH homeostasis) and support metabolic flux between compartments (PubMed:35063410). In addition to its metabolic role, binds to RNA in cells, associating with cytosolic RNAs including tRNAs and mRNAs (By similarity). {ECO:0000250|UniProtKB:P40926, ECO:0000269|PubMed:35063410, ECO:0000269|PubMed:36815302}.
uniprot
proteins
mass_dalton
35611
uniprot
proteins
post_translational_modification
PTM: Acetylation is enhanced after treatment either with trichostin A (TCA) or with nicotinamide (NAM) with the appearance of tri- and tetraacetylations. Glucose also increases acetylation (By similarity). Acetylation of Lys-239 and Lys-314 is observed in liver mitochondria from fasted mice but not from fed mice. {ECO:0000250|UniProtKB:P40926}.; PTM: Deacetylation by SIRT3 leads to decreased enzymatic activity and promotes mitochondrial fusion. {ECO:0000269|PubMed:36815302}.
uniprot
proteins
protein_family
LDH/MDH superfamily
uniprot
proteins
protein_family
MDH type 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16751257
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
3038184
uniprot
proteins
pubmed
3379635
uniprot
proteins
pubmed
35063410
uniprot
proteins
pubmed
36815302
uniprot
proteins
sequence_length
338
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:P40926}.
uniprot
proteins