Acaa2
entrez
170465
canonical
uniprot
P13437
canonical
ensembl
ENSRNOG00000013766
resolver
ensp
ENSRNOP00000060140
resolver
enst
ENSRNOT00000067018
resolver
genesymbol
Acaa2
resolver
uniprot
G3V9U2
resolver
uniprot_entry
G3V9U2_RAT
resolver
uniprot_entry
THIM_RAT
resolver
activity_regulation
ACTIVITY REGULATION: The 3-oxoacetyl-CoA thiolase activity is inhibited by acetyl-CoA while the acetyl-CoA hydrolase activity is inhibited by acetoacetyl-CoA. {ECO:0000269|PubMed:16476568}.
uniprot
proteins
amino_acid_sequence
MALLRGVFIVAAKRTPFGAYGGLLKDFTATDLTEFAARAALSAGKVPPETIDSVIVGNVMQSSSDAAYLARHVGLRVGVPTETGALTLNRLCGSGFQSIVSGCQEICSKDAEVVLCGGTESMSQSPYSVRNVRFGTKFGLDLKLEDTLWAGLTDQHVKLPMGMTAENLAAKYNISREDCDRYALQSQQRWKAANEAGYFNEEMAPIEVKTKKGKQTMQVDEHARPQTTLEQLQNLPPVFKKEGTVTAGNASGMSDGAGVVIIASEDAVKKHNFTPLARVVGYFVSGCDPAIMGIGPVPAITGALKKAGLSLKDMDLIDVNEAFAPQFLAVQKSLDLDPSKTNVSGGAIALGHPLGGSGSRITAHLVHELRRRGGKYAVGSACIGGGQGISLIIQNTA
uniprot
proteins
ec_number
2.3.1.16
uniprot
proteins
ec_number
2.3.1.9
uniprot
proteins
ec_number
3.1.2.-
uniprot
proteins
ec_number
3.1.2.1
uniprot
proteins
ec_number
3.1.2.2
uniprot
proteins
function
FUNCTION: In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable). Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable). Also displays hydrolase activity on various fatty acyl-CoAs (PubMed:16476568). Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable). Abolishes BNIP3-mediated apoptosis and mitochondrial damage (By similarity). {ECO:0000250|UniProtKB:P42765, ECO:0000269|PubMed:16476568, ECO:0000305|PubMed:16476568}.
uniprot
proteins
mass_dalton
41871
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid beta-oxidation. {ECO:0000269|PubMed:16476568}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the SCF(FBXO42) complex; leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q8BWT1}.
uniprot
proteins
protein_family
Thiolase family
uniprot
proteins
protein_family
Thiolase-like superfamily
uniprot
proteins
pubmed
16476568
uniprot
proteins
pubmed
3038520
uniprot
proteins
sequence_length
397
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16476568}.
uniprot
proteins