Abraxas1
entrez
70681
canonical
uniprot
Q8BPZ8
canonical
ensembl
ENSMUSG00000035234
resolver
ensp
ENSMUSP00000055895
resolver
genesymbol
Abraxas1
resolver
genesymbol_syn
Abra1
resolver
genesymbol_syn
Ccdc98
resolver
genesymbol_syn
Fam175a
resolver
uniprot
Q3TJ88
resolver
uniprot
Q8BFV6
resolver
uniprot
Q8BT69
resolver
uniprot
Q8K2T7
resolver
uniprot_entry
ABRX1_MOUSE
resolver
uniprot_sec
Q3TJ88
resolver
uniprot_sec
Q8BFV6
resolver
uniprot_sec
Q8BT69
resolver
uniprot_sec
Q8K2T7
resolver
amino_acid_sequence
MEGESTLGVLSGFVLGALTFHHLNTDSDTEGFLLGEMKGEAKNSITDSQMDNVKVVYTIDIQKYIPCYRLFSFYNSLGEVNEHALKKVLSNVRKTVVGWYKFRRHSDQIMTFREQLLHRNLQTHLSSPELVFLLLTPSITTESCSTHCLEHALYKPQRGLFHRVPLVVTNLGMSDQLGYKTEPASCTSTVFSRAVRTHSSQFFNEDGSLKEVHKINEMYAAVQEELKSICQKVEQSEREVEKLLMDVNQLKEVRRTQQARATGAGEKNVQRNPQENILLCQALRTFFPESEVLHSCVISLKNRHISPSGCNVNHHVDVVDQLTLMVEYVYSPEASPVPTAQLRKRKALDTHDQGSVKRPRLLETESRPSVAASRSRHQDKASSSSLDIDIEMGSPEDDADYPRSPTF
uniprot
proteins
function
FUNCTION: Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. {ECO:0000250|UniProtKB:Q6UWZ7}.
uniprot
proteins
mass_dalton
46039
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Ser-404 of the pSXXF motif by ATM or ATR constitutes a specific recognition motif for the BRCT domain of BRCA1. {ECO:0000250|UniProtKB:Q6UWZ7}.
uniprot
proteins
protein_family
Abraxas subfamily
uniprot
proteins
protein_family
FAM175 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
407
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6UWZ7}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). {ECO:0000250|UniProtKB:Q6UWZ7}.
uniprot
proteins