Srd5a3
entrez
305291
canonical
uniprot
Q5RJM1
canonical
ensembl
ENSRNOG00000002216
resolver
ensp
ENSRNOP00000003021
resolver
ensp
ENSRNOP00000056514
resolver
enst
ENSRNOT00000059763
resolver
genesymbol
Srd5a3
resolver
uniprot
A0A140TAI0
resolver
uniprot
D3ZUS5
resolver
uniprot
D4A5U7
resolver
uniprot_entry
A0A140TAI0_RAT
resolver
uniprot_entry
SR5A3_RAT
resolver
uniprot_sec
D3ZUS5
resolver
uniprot_sec
D4A5U7
resolver
amino_acid_sequence
MAGWAGAELSVLNPLRALWLLLAAAFLLALLLQLAPARLLPSCALFQDLIRYGKTKQSGSRRPAVCRAFDVPKRYFSHFYVVSVLWNGSLLWFLSQSLFLGAPFPSWLWALLRTLGVTQFQALGMESKASRIQGKKLALSTFLVLVFLWVHSLRRLFECFYVSVFSNTAIHVVQYCFGLVYYVLVGLTVLSQVPMNDKNVYALGKNLLLQARWFHILGMMMFFWSSAHQYKCHVILSNLRRNKKGVVIHCQHRIPFGDWFEYVSSANYLAELMIYISMAVTFGLHNVTWWLVVTYVFFSQALSAFFNHRFYKSTFVSYPKHRKAFLPFLF
uniprot
proteins
ec_number
1.3.1.22
uniprot
proteins
ec_number
1.3.1.94
uniprot
proteins
function
FUNCTION: Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol (PubMed:8486680). Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism (By similarity). Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation (PubMed:8486680). Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT) (By similarity). {ECO:0000250|UniProtKB:Q9H8P0, ECO:0000269|PubMed:8486680}.
uniprot
proteins
mass_dalton
38092
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:8486680}.
uniprot
proteins
protein_family
Polyprenal reductase subfamily
uniprot
proteins
protein_family
Steroid 5-alpha reductase family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8486680
uniprot
proteins
sequence_length
330
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:8486680}; Multi-pass membrane protein {ECO:0000269|PubMed:8486680}.
uniprot
proteins
transmembrane_region
TRANSMEM 17..37; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 90..110; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 137..157; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 170..190; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 207..227; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 278..298; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins