Rad23b
entrez
298012
canonical
uniprot
Q4KMA2
canonical
ensembl
ENSRNOG00000016137
resolver
ensembl
ENSRNOG00055018256
resolver
ensembl
ENSRNOG00060009806
resolver
ensembl
ENSRNOG00065015267
resolver
ensp
ENSRNOP00000021629
resolver
ensp
ENSRNOP00055024925
resolver
ensp
ENSRNOP00060012933
resolver
ensp
ENSRNOP00065019824
resolver
enst
ENSRNOT00000021629
resolver
enst
ENSRNOT00055030940
resolver
enst
ENSRNOT00060016552
resolver
enst
ENSRNOT00065025298
resolver
genesymbol
Rad23b
resolver
uniprot
Q0D2G8
resolver
uniprot
Q5CZZ8
resolver
uniprot
Q6IRD5
resolver
uniprot_entry
RD23B_RAT
resolver
uniprot_sec
Q0D2G8
resolver
uniprot_sec
Q5CZZ8
resolver
uniprot_sec
Q6IRD5
resolver
amino_acid_sequence
MQVTLKTLQQQTFKIDIDPEETVKALKEKIESEKGKDAFPVAGQKLIYAGKILSDDTALKEYKIDEKNFVVVMVTKPKAVTSAVPATTQQSSSPSTTTVSSSPAAAVAQAPAPTPALAPTSTPASTTPASTTASSEPAPTGATQPEKPAEKPAQTPVLTSPAPADSTPGDSSRSNLFEDATSALVTGQSYENMVTEIMSMGYEREQVIAALRASFNNPDRAVEYLLMGIPGDRESQAVVDPPPQAVSTGTPQSPAVAAAAATTTATTTTTSGGHPLEFLRNQPQFQQMRQIIQQNPSLLPALLQQIGRENPQLLQQISQHQEHFIQMLNEPVQEAGGQGGGGGGGGGGGGGGGGIAEAGSGHMNYIQVTPQEKEAIERLKALGFPEGLVIQAYFACEKNENLAANFLLQQNFDED
uniprot
proteins
ec_number
1.14.11.-
uniprot
proteins
function
FUNCTION: Multifunctional protein that participates in histone H4K20 demethylation, DNA repair, ubiquitin-dependent protein degradation and transcriptional regulation. Specifically demethylates mono-, di- and trimethylated 'Lys-20' of histone H4 (H4K20me1, H4K20me2, H4K20me3, respectively) into unmethylated forms. Activates the transcription of coding genes by demethylating H4K20me1 and the transcription of repetitive elements by demethylating H4K20me3. Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex, a nucleotide-excision repair complex that is involved in damage sensing during global genome nucleotide excision repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA. Recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix including single-stranded loops, mismatched bubbles or single-stranded overhangs. Cooperatively with CETN2 appears to stabilize XPC. {ECO:0000250|UniProtKB:P54727}.
uniprot
proteins
mass_dalton
43497
uniprot
proteins
protein_family
RAD23 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
415
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P54728}. Cytoplasm {ECO:0000250|UniProtKB:P54728}.
uniprot
proteins