DCD
entrez
117159
canonical
uniprot
P81605
canonical
ensembl
ENSG00000161634
resolver
ensp
ENSP00000293371
resolver
ensp
ENSP00000406773
resolver
genesymbol
DCD
resolver
genesymbol_syn
AIDD
resolver
genesymbol_syn
DSEP
resolver
hgnc
HGNC:14669
resolver
uniprot
A5JHP2
resolver
uniprot
A5JHP3
resolver
uniprot
P58461
resolver
uniprot
Q53YJ2
resolver
uniprot_entry
DCD_HUMAN
resolver
uniprot_sec
A5JHP2
resolver
uniprot_sec
A5JHP3
resolver
uniprot_sec
P58461
resolver
uniprot_sec
Q53YJ2
resolver
amino_acid_sequence
MRFMTLLFLTALAGALVCAYDPEAASAPGSGNPCHEASAAQKENAGEDPGLARQAPKPRKQRSSLLEKGLDGAKKAVGGLGKLGKDAVEDLESVGKGAVHDVKDVLDSVL
uniprot
proteins
ec_number
3.4.-.-
uniprot
proteins
function
FUNCTION: [DCD-1]: Found in sweat, has an antimicrobial activity during early bacterial colonization (PubMed:11694882, PubMed:23426625). The secreted peptide assembles into homohexameric complexes that can associate with and also insert into pathogen membranes (PubMed:23426625). Once inserted in bacteria membranes forms anion channels probably altering the transmembrane potential essential for bacterial survival (PubMed:23426625). Highly effective against E.coli, E.faecalis, S.aureus and C.albicans (PubMed:11694882). Optimal pH and salt concentration resemble the conditions in sweat (PubMed:11694882). Also exhibits proteolytic activity, cleaving on the C-terminal side of Arg and, to a lesser extent, Lys residues (PubMed:17448443). {ECO:0000269|PubMed:11694882, ECO:0000269|PubMed:17448443, ECO:0000269|PubMed:23426625}.; FUNCTION: [Survival-promoting peptide]: Promotes survival of neurons and displays phosphatase activity (PubMed:9736629). It may bind IgG (PubMed:9736629). {ECO:0000269|PubMed:9736629}.
uniprot
proteins
mass_dalton
11284
uniprot
proteins
mutagenesis
MUTAGEN 100; /note="H->A: Loss of anion channel activity."; /evidence="ECO:0000269|PubMed:23426625
uniprot
proteins
pubmed
11694882
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17448443
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20510021
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23426625
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25326458
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
25946035
uniprot
proteins
pubmed
36213313
uniprot
proteins
pubmed
37453717
uniprot
proteins
pubmed
9736629
uniprot
proteins
sequence_length
110
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11694882, ECO:0000269|PubMed:15340161, ECO:0000269|PubMed:25326458, ECO:0000269|PubMed:25946035, ECO:0000269|PubMed:36213313, ECO:0000269|PubMed:37453717, ECO:0000269|PubMed:9736629}.; SUBCELLULAR LOCATION: [Survival-promoting peptide]: Secreted {ECO:0000269|PubMed:9736629}.; SUBCELLULAR LOCATION: [DCD-1]: Secreted {ECO:0000305|PubMed:23426625}. Membrane {ECO:0000269|PubMed:23426625}; Peripheral membrane protein {ECO:0000269|PubMed:23426625}. Membrane {ECO:0000269|PubMed:23426625}; Single-pass membrane protein {ECO:0000269|PubMed:23426625}. Note=The secreted peptide assembles into homohexameric complexes that can probably associate with pathogen membranes and also insert into these membranes where they behave as channels. {ECO:0000269|PubMed:23426625}.
uniprot
proteins
transmembrane_region
TRANSMEM 64..108; /note="Helical"; /evidence="ECO:0000305|PubMed:23426625
uniprot
proteins