CYP51A1
entrez
1595
canonical
uniprot
Q16850
canonical
ensembl
ENSG00000001630
resolver
ensp
ENSP00000003100
resolver
ensp
ENSP00000406757
resolver
genesymbol
CYP51A1
resolver
genesymbol_syn
CYP51
resolver
hgnc
HGNC:2649
resolver
uniprot
A0A0C4DFL7
resolver
uniprot
A4D1F8
resolver
uniprot
B2RAI4
resolver
uniprot
B4DJ55
resolver
uniprot
O00770
resolver
uniprot
O00772
resolver
uniprot
Q16784
resolver
uniprot
Q8N1A8
resolver
uniprot
Q99868
resolver
uniprot_entry
CP51A_HUMAN
resolver
uniprot_sec
A0A0C4DFL7
resolver
uniprot_sec
A4D1F8
resolver
uniprot_sec
B2RAI4
resolver
uniprot_sec
B4DJ55
resolver
uniprot_sec
O00770
resolver
uniprot_sec
O00772
resolver
uniprot_sec
Q16784
resolver
uniprot_sec
Q8N1A8
resolver
uniprot_sec
Q99868
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by azalanstat. Inhibited by azole antifungal agents ketoconazole, itraconazole and fluconazole. {ECO:0000250|UniProtKB:Q64654}.
uniprot
proteins
amino_acid_sequence
MAAAAGMLLLGLLQAGGSVLGQAMEKVTGGNLLSMLLIACAFTLSLVYLIRLAAGHLVQLPAGVKSPPYIFSPIPFLGHAIAFGKSPIEFLENAYEKYGPVFSFTMVGKTFTYLLGSDAAALLFNSKNEDLNAEDVYSRLTTPVFGKGVAYDVPNPVFLEQKKMLKSGLNIAHFKQHVSIIEKETKEYFESWGESGEKNVFEALSELIILTASHCLHGKEIRSQLNEKVAQLYADLDGGFSHAAWLLPGWLPLPSFRRRDRAHREIKDIFYKAIQKRRQSQEKIDDILQTLLDATYKDGRPLTDDEVAGMLIGLLLAGQHTSSTTSAWMGFFLARDKTLQKKCYLEQKTVCGENLPPLTYDQLKDLNLLDRCIKETLRLRPPIMIMMRMARTPQTVAGYTIPPGHQVCVSPTVNQRLKDSWVERLDFNPDRYLQDNPASGEKFAYVPFGAGRHRCIGENFAYVQIKTIWSTMLRLYEFDLIDGYFPTVNYTTMIHTPENPVIRYKRRSK
uniprot
proteins
ec_number
1.14.14.154
uniprot
proteins
function
FUNCTION: Sterol 14alpha-demethylase that plays a critical role in the cholesterol biosynthesis pathway, being cholesterol the major sterol component in mammalian membranes as well as a precursor for bile acid and steroid hormone synthesis (PubMed:20149798, PubMed:8619637, PubMed:9559662). Cytochrome P450 monooxygenase that catalyzes the three-step oxidative removal of the 14alpha-methyl group (C-32) of sterols such as lanosterol (lanosta-8,24-dien-3beta-ol) and 24,25-dihydrolanosterol (DHL) in the form of formate, and converts the sterols to 4,4-dimethyl-5alpha-cholesta-8,14,24-trien-3beta-ol and 4,4-dimethyl-8,14-cholestadien-3beta-ol, respectively, which are intermediates of cholesterol biosynthesis (PubMed:20149798, PubMed:8619637, PubMed:9559662). Can also demethylate substrates not intrinsic to mammals, such as eburicol (24-methylene-24,25-dihydrolanosterol), but at a lower rate than DHL (PubMed:9559662). {ECO:0000269|PubMed:20149798, ECO:0000269|PubMed:8619637, ECO:0000269|PubMed:9559662}.
uniprot
proteins
mass_dalton
57278
uniprot
proteins
pathway_participation
PATHWAY: Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 1/6. {ECO:0000305|PubMed:8619637}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by MARCHF6, leading to proteasomal degradation. {ECO:0000269|PubMed:31904814}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20149798
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
31904814
uniprot
proteins
pubmed
8619637
uniprot
proteins
pubmed
8797093
uniprot
proteins
pubmed
8809088
uniprot
proteins
pubmed
8975714
uniprot
proteins
pubmed
9559662
uniprot
proteins
sequence_length
509
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q64654}; Single-pass membrane protein {ECO:0000255}. Microsome membrane {ECO:0000250|UniProtKB:Q64654}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 30..50; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins