Ptchd1
entrez
211612
canonical
uniprot
Q14B62
canonical
ensembl
ENSMUSG00000041552
resolver
ensp
ENSMUSP00000039443
resolver
ensp
ENSMUSP00000194615
resolver
genesymbol
Ptchd1
resolver
genesymbol
ptchd1
resolver
genesymbol_syn
AI848149
resolver
uniprot
B1AZU9
resolver
uniprot
Q14B63
resolver
uniprot
Q3UR40
resolver
uniprot
Q8BZA5
resolver
uniprot_entry
PTHD1_MOUSE
resolver
uniprot_entry
Q3UR40_MOUSE
resolver
uniprot_sec
B1AZU9
resolver
uniprot_sec
Q14B63
resolver
uniprot_sec
Q8BZA5
resolver
amino_acid_sequence
MLRQVLHRGLRTCFSRLGHFIASHPVFFASAPVLISILLGASFSRYQVEESVEHLLAPQHSLAKIERNLVNSLFPVNRSKHRLYSDLQTPGRYGRVIVTSYQKANMLDQHHTDLILKLHTAVTKIQVPRPGFNYTFAHICVLNNDKTCIVDDIVHVLEELKNARATNRTNFAITYPITHLKDGRAVYNGHQLGGVTVHSKDRVKSAEAIQLTYYLQSINSLNDMVAERWESSFCDTVKLFQKSNSKVKIYPYTSSSLREDFQKTSRVSERYLVTSLILVVTMAILCCSMQDCVRSKPWLGLLGLVTISLATLTAAGIINLTGGKYNSTFLGVPFVMLGHGLYGTFEMLSSWRKTREDQHVKERTAEVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIAILFNYLYVLSFYGSSLVFTGYIENNYQHSIFCRKVPKPDVLQEKPAWYRFLLTARFSEETAEGEEANTYESHLLVCFLKRYYCDWITNTYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNIVATATQTIEYTTAHQKYFNNYSPVIGFYIYESIEYWNSSVQEDVLEYTKGFVRISWFESYLNYLRKLNVSTDLPKKNFTDMLRNSFLKTPQFSHFQEDIIFSKKYNDEVDVVASRMFLVAKTMETNREELYDLLETLRRLSVTSKVKFIVFNPSFVYMDRYASSLGAPLHNSCISALFLLFFSAFLVADSLINVWITLTVVSVEFGVIGFMTLWKVELDCISVLCLIYGINYTIDNCAPLLSTFVLGKDFTRTKWVKNALEVHGVAILQSYLCYIVGLFPLAAVPSNLTCTLFRCLFLIAFVTFFHCFAILPVILTFLPPSKKKRKEKKNPENREEIECVEMVDIDSTRVVDQITTV
uniprot
proteins
function
FUNCTION: Required for the development and function of the thalamic reticular nucleus (TRN), a part of the thalamus that is critical for thalamocortical transmission, generation of sleep rhythms, sensorimotor processing and attention. Can bind cholesterol in vitro (By similarity). {ECO:0000250|UniProtKB:Q96NR3, ECO:0000269|PubMed:27007844}.
uniprot
proteins
mass_dalton
101506
uniprot
proteins
mutagenesis
MUTAGEN 32; /note="P->R: Results in defective post-translational processing and glycosylation. Decreased protein half-life and stability."; /evidence="ECO:0000269|PubMed:38275824"; MUTAGEN 75; /note="P->Q: No effect on post-translational processing. No effect on protein half-life and stability."; /evidence="ECO:0000269|PubMed:38275824"; MUTAGEN 181; /note="K->T: No effect on post-translational processing."; /evidence="ECO:0000269|PubMed:38275824"; MUTAGEN 303; /note="G->R: Results in defective post-translational processing and glycosylation."; /evidence="ECO:0000269|PubMed:38275824"; MUTAGEN 549; /note="F->C: Results in defective post-translational processing and glycosylation. Decreased protein half-life and stability."; /evidence="ECO:0000269|PubMed:38275824"; MUTAGEN 885..888; /note="Missing: No effect on post-translational processing. No effect on protein half-life and stability."; /evidence="ECO:0000269|PubMed:38275824
uniprot
proteins
protein_family
Patched family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20844286
uniprot
proteins
pubmed
27007844
uniprot
proteins
pubmed
38275824
uniprot
proteins
sequence_length
888
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q96NR3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96NR3}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q96NR3}.
uniprot
proteins
transmembrane_region
TRANSMEM 20..40; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 273..293; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 298..318; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 328..348; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 373..393; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 407..427; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 502..522; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 707..727; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 738..758; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 795..815; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 826..846; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins