CHRNA9
entrez
55584
canonical
uniprot
Q9UGM1
canonical
ensembl
ENSG00000174343
resolver
ensp
ENSP00000312663
resolver
enst
ENST00000310169
resolver
genesymbol
CHRNA9
resolver
genesymbol_syn
NACHRA9
resolver
hgnc
HGNC:14079
resolver
uniprot
Q14CY7
resolver
uniprot
Q4W5A2
resolver
uniprot
Q9NYV2
resolver
uniprot_entry
ACHA9_HUMAN
resolver
uniprot_sec
Q14CY7
resolver
uniprot_sec
Q4W5A2
resolver
uniprot_sec
Q9NYV2
resolver
activity_regulation
ACTIVITY REGULATION: Activated by a myriad of ligands such as acetylcholine (PubMed:22774872). AChR activity is inhibited by the antagonist alpha-conotoxins RgIA and GeXXA, small disulfide-constrained peptides from cone snails (PubMed:22774872). {ECO:0000269|PubMed:22774872}.
uniprot
proteins
amino_acid_sequence
MNWSHSCISFCWIYFAASRLRAAETADGKYAQKLFNDLFEDYSNALRPVEDTDKVLNVTLQITLSQIKDMDERNQILTAYLWIRQIWHDAYLTWDRDQYDGLDSIRIPSDLVWRPDIVLYNKADDESSEPVNTNVVLRYDGLITWDAPAITKSSCVVDVTYFPFDNQQCNLTFGSWTYNGNQVDIFNALDSGDLSDFIEDVEWEVHGMPAVKNVISYGCCSEPYPDVTFTLLLKRRSSFYIVNLLIPCVLISFLAPLSFYLPAASGEKVSLGVTILLAMTVFQLMVAEIMPASENVPLIGKYYIATMALITASTALTIMVMNIHFCGAEARPVPHWARVVILKYMSRVLFVYDVGESCLSPHHSRERDHLTKVYSKLPESNLKAARNKDLSRKKDMNKRLKNDLGCQGKNPQEAESYCAQYKVLTRNIEYIAKCLKDHKATNSKGSEWKKVAKVIDRFFMWIFFIMVFVMTILIIARAD
uniprot
proteins
function
FUNCTION: Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:11752216, PubMed:18723036, PubMed:25282151). Forms either homopentamers or heteropentamers with CHRNA10. Expressed in the inner ear, in sympathetic neurons and in other non-neuronal cells, such as skin keratinocytes and lymphocytes (PubMed:11752216, PubMed:18723036). nAChR formed by CHRNA9:CHRNA10 mediate central nervous system control of auditory and vestibular sensory processing. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane (PubMed:11752216, PubMed:25282151). In the ear, mediates synaptic transmission between efferent olivocochlear fibers and hair cells of the cochlea, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma (By similarity). May also regulate keratinocyte adhesion (PubMed:11021840, PubMed:11752216, PubMed:25282151). {ECO:0000250|UniProtKB:P43144, ECO:0000269|PubMed:11021840, ECO:0000269|PubMed:11752216, ECO:0000269|PubMed:18723036, ECO:0000269|PubMed:25282151, ECO:0000303|PubMed:18723036}.
uniprot
proteins
mass_dalton
54807
uniprot
proteins
mutagenesis
MUTAGEN 86; /note="I->T: The CHRNA9:CHRNA10 receptor is 250-fold more potently inhibited by the alpha-conotoxin RgIA."; /evidence="ECO:0000269|PubMed:22774872"; MUTAGEN 172; /note="T->K: Decreases response to acetylcholine."; /evidence="ECO:0000269|PubMed:25282151"; MUTAGEN 228; /note="T->A: Loss of response to acetylcholine."; /evidence="ECO:0000269|PubMed:25282151
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:25282151}.
uniprot
proteins
protein_family
Acetylcholine receptor (TC 1.A.9.1) subfamily
uniprot
proteins
protein_family
Alpha-9/CHRNA9 sub-subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
11021840
uniprot
proteins
pubmed
11752216
uniprot
proteins
pubmed
12697997
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15531379
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18723036
uniprot
proteins
pubmed
22774872
uniprot
proteins
pubmed
25282151
uniprot
proteins
sequence_length
479
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Synaptic cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:25282151}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 239..259; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 269..289; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 303..323; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 458..478; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins