SNW1
entrez
22938
canonical
uniprot
Q13573
canonical
ensembl
ENSG00000100603
resolver
ensp
ENSP00000261531
resolver
ensp
ENSP00000451129
resolver
ensp
ENSP00000667913
resolver
enst
ENST00000261531
resolver
enst
ENST00000555761
resolver
genesymbol
SNW1
resolver
genesymbol_syn
SKIIP
resolver
genesymbol_syn
SKIP
resolver
hgnc
HGNC:16696
resolver
uniprot
A8K8A9
resolver
uniprot
G3V3A4
resolver
uniprot
Q13483
resolver
uniprot
Q32N03
resolver
uniprot
Q5D0D6
resolver
uniprot_entry
G3V3A4_HUMAN
resolver
uniprot_entry
SNW1_HUMAN
resolver
uniprot_sec
A8K8A9
resolver
uniprot_sec
Q13483
resolver
uniprot_sec
Q32N03
resolver
uniprot_sec
Q5D0D6
resolver
amino_acid_sequence
MALTSFLPAPTQLSQDQLEAEEKARSQRSRQTSLVSSRREPPPYGYRKGWIPRLLEDFGDGGAFPEIHVAQYPLDMGRKKKMSNALAIQVDSEGKIKYDAIARQGQSKDKVIYSKYTDLVPKEVMNADDPDLQRPDEEAIKEITEKTRVALEKSVSQKVAAAMPVRAADKLAPAQYIRYTPSQQGVAFNSGAKQRVIRMVEMQKDPMEPPRFKINKKIPRGPPSPPAPVMHSPSRKMTVKEQQEWKIPPCISNWKNAKGYTIPLDKRLAADGRGLQTVHINENFAKLAEALYIADRKAREAVEMRAQVERKMAQKEKEKHEEKLREMAQKARERRAGIKTHVEKEDGEARERDEIRHDRRKERQHDRNLSRAAPDKRSKLQRNENRDISEVIALGVPNPRTSNEVQYDQRLFNQSKGMDSGFAGGEDEIYNVYDQAWRGGKDMAQSIYRPSKNLDKDMYGDDLEARIKTNRFVPDKEFSGSDRRQRGREGPVQFEEDPFGLDKFLEEAKQHGGSKRPSDSSRPKEHEHEGKKRRKE
uniprot
proteins
function
FUNCTION: Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346, PubMed:28502770). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Required for the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. May recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, RB1-mediated transcriptional repression, and retinoid-X receptor (RXR)- and vitamin D receptor (VDR)-dependent gene transcription in a cell line-specific manner probably involving coactivators NCOA1 and GRIP1. Is involved in NOTCH1-mediated transcriptional activation. Binds to multimerized forms of Notch intracellular domain (NICD) and is proposed to recruit transcriptional coactivators such as MAML1 to form an intermediate preactivation complex which associates with DNA-bound CBF-1/RBPJ to form a transcriptional activation complex by releasing SNW1 and redundant NOTCH1 NICD. {ECO:0000269|PubMed:10644367, ECO:0000269|PubMed:11278756, ECO:0000269|PubMed:11371506, ECO:0000269|PubMed:11514567, ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12840015, ECO:0000269|PubMed:14985122, ECO:0000269|PubMed:15194481, ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:18794151, ECO:0000269|PubMed:19818711, ECO:0000269|PubMed:21245387, ECO:0000269|PubMed:21460037, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:9632709, ECO:0000305|PubMed:33509932}.; FUNCTION: (Microbial infection) Is recruited by HIV-1 Tat to Tat:P-TEFb:TAR RNA complexes and is involved in Tat transcription by recruitment of MYC, MEN1 and TRRAP to the HIV promoter. {ECO:0000269|PubMed:15905409, ECO:0000269|PubMed:19818711}.; FUNCTION: (Microbial infection) Proposed to be involved in transcriptional activation by EBV EBNA2 of CBF-1/RBPJ-repressed promoters. {ECO:0000269|PubMed:10644367}.
uniprot
proteins
mass_dalton
61494
uniprot
proteins
mutagenesis
MUTAGEN 66; /note="E->A,R: Abolishes interaction with PPIL1."; /evidence="ECO:0000269|PubMed:20007319"; MUTAGEN 76; /note="M->A: Abolishes interaction with PPIL1."; /evidence="ECO:0000269|PubMed:20007319
uniprot
proteins
protein_family
SNW family
uniprot
proteins
pubmed
10644367
uniprot
proteins
pubmed
10713164
uniprot
proteins
pubmed
11278756
uniprot
proteins
pubmed
11371506
uniprot
proteins
pubmed
11514567
uniprot
proteins
pubmed
11753645
uniprot
proteins
pubmed
11991638
uniprot
proteins
pubmed
12466551
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
12529369
uniprot
proteins
pubmed
12840015
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14985122
uniprot
proteins
pubmed
15194481
uniprot
proteins
pubmed
15316101
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15905409
uniprot
proteins
pubmed
16102918
uniprot
proteins
pubmed
16595688
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18794151
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19818711
uniprot
proteins
pubmed
20007319
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20368803
uniprot
proteins
pubmed
21245387
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21460037
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
28076346
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28502770
uniprot
proteins
pubmed
33220177
uniprot
proteins
pubmed
33509932
uniprot
proteins
pubmed
8973337
uniprot
proteins
pubmed
9569025
uniprot
proteins
pubmed
9632709
uniprot
proteins
sequence_length
536
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11991638, ECO:0000269|PubMed:12840015, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770}.
uniprot
proteins