Aars1
entrez
292023
canonical
uniprot
P50475
canonical
ensembl
ENSRNOG00000018404
resolver
ensp
ENSRNOP00000025051
resolver
enst
ENSRNOT00000025052
resolver
genesymbol
Aars1
resolver
genesymbol_syn
Aars
resolver
uniprot
A6IZ80
resolver
uniprot
Q4G057
resolver
uniprot_entry
SYAC_RAT
resolver
uniprot_sec
A6IZ80
resolver
uniprot_sec
Q4G057
resolver
activity_regulation
ACTIVITY REGULATION: The protein lactyltransferase activity is inhibited by beta-alanine. {ECO:0000250|UniProtKB:P49588}.
uniprot
proteins
amino_acid_sequence
MDSTLTAREIRERFINYFKRNEHTYVHSSATIPLDDPTLLFANAGMNQFKPIFLNTVDPSHPMAKLSRAANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGSWSFGDYFKELACKMALELLTQEFGIPVERLYVTYFGGDEAAGLEPDLECRQIWQNLGLDEAKILPGNMKDNFWEMGDTGPCGPCSEIHYDRIGGRDAAHLVNQDDPNVLEIWNLVFIQYNRESDGVLKPLPKKSIDTGMGLERLVSVLQNKMSNYDTDLFVPYFEAIQKGTGARPYTGKVGAEDTDGIDMAYRVLADHARTITVALADGGRPDNTGRGYVLRRILRRAVRYSHEKLNASRGFFATLVDVVVQSLGDAFPELKKDPDMVKDIINEEEVQFLKTLSRGRRILDRKIQSLGDCQTIPGDTAWLLYDTYGFPVDLTGLIAEEKGLVVDMDGFEEERKLAQLKSQGKGAGGEDLIMLDIYAIEELRAKGLEATDDSPKYNYHSDSSGSYVFECTVATVLALRREKMFVDEVVTGQECGVVLDKTCFYAEQGGQIFDEGYLVKVDDSSEDKTEFTVKNAQVRGGYVLHIGTIYGNLRVGDQVRLFIDEPRRRPVMSNHTATHILNFALRSVLGDADQKGSLVAPDRLRFDFTAKGAMSTEQIKKTEEIVNGMIEAAKPVYTLDCPLAAAKAIQGLRAVFDETYPDPVRVVSIGVPVSELLDDPSGPAGSLTSVEFCGGTHLRNSSHAGAFVIVTEEAIAKGIRRIVAVTGAEAQKALRKSETLKKSLSAMEVKVKAQSAPNKDVQKEIADLGEVLATAVIPQWQKDEQRETLKSLKKVMDDLDRASKADVQKRVLEKTKQLIDSNPNQPLVILEMESGASAKALNEALKLFKTHSPQTSAMLFTVDNEAGKITCLCQVPQNAANRGLKASEWVQQVSGLMDGKGGGKDMSAQATGKNVGCLQEALQLATSFAQLRLGDVKN
uniprot
proteins
ec_number
6.-.-.-
uniprot
proteins
ec_number
6.1.1.7
uniprot
proteins
function
FUNCTION: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as TEAD1, TP53/p53 and YAP1. Protein lactylation takes place in a two-step reaction: lactate is first activated by ATP to form lactate-AMP and then transferred to lysine residues of target proteins. Acts as an inhibitor of TP53/p53 activity by catalyzing lactylation of TP53/p53. Acts as a positive regulator of the Hippo pathway by mediating lactylation of TEAD1 and YAP1. {ECO:0000255|HAMAP-Rule:MF_03133}.
uniprot
proteins
mass_dalton
106790
uniprot
proteins
post_translational_modification
PTM: ISGylated. {ECO:0000255|HAMAP-Rule:MF_03133}.; PTM: Methylation at 'Lys-943' by METTL21C. {ECO:0000250|UniProtKB:P49588}.
uniprot
proteins
protein_family
Class-II aminoacyl-tRNA synthetase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2040280
uniprot
proteins
sequence_length
968
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03133}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03133}. Note=Translocates to the nucleus in response to increased levels of lactate; nuclear translocation is dependent on KPNA4. {ECO:0000255|HAMAP-Rule:MF_03133}.
uniprot
proteins