ADAM33
entrez
80332
canonical
uniprot
Q9BZ11
canonical
ensembl
ENSG00000149451
resolver
ensp
ENSP00000322550
resolver
ensp
ENSP00000348912
resolver
ensp
ENSP00000369190
resolver
ensp
ENSP00000552104
resolver
ensp
ENSP00000552105
resolver
ensp
ENSP00000552106
resolver
ensp
ENSP00000552110
resolver
ensp
ENSP00000552111
resolver
ensp
ENSP00000629357
resolver
ensp
ENSP00000691409
resolver
enst
ENST00000379861
resolver
genesymbol
ADAM33
resolver
genesymbol_syn
C20orf153
resolver
hgnc
HGNC:15478
resolver
uniprot
A0A1K6
resolver
uniprot
A2A2L3
resolver
uniprot
Q5JT75
resolver
uniprot
Q5JT76
resolver
uniprot
Q8N0W6
resolver
uniprot_entry
A2A2L3_HUMAN
resolver
uniprot_entry
ADA33_HUMAN
resolver
uniprot_sec
A0A1K6
resolver
uniprot_sec
Q5JT75
resolver
uniprot_sec
Q5JT76
resolver
uniprot_sec
Q8N0W6
resolver
amino_acid_sequence
MGWRPRRARGTPLLLLLLLLLLWPVPGAGVLQGHIPGQPVTPHWVLDGQPWRTVSLEEPVSKPDMGLVALEAEGQELLLELEKNHRLLAPGYIETHYGPDGQPVVLAPNHTDHCHYQGRVRGFPDSWVVLCTCSGMSGLITLSRNASYYLRPWPPRGSKDFSTHEIFRMEQLLTWKGTCGHRDPGNKAGMTSLPGGPQSRGRREARRTRKYLELYIVADHTLFLTRHRNLNHTKQRLLEVANYVDQLLRTLDIQVALTGLEVWTERDRSRVTQDANATLWAFLQWRRGLWAQRPHDSAQLLTGRAFQGATVGLAPVEGMCRAESSGGVSTDHSELPIGAAATMAHEIGHSLGLSHDPDGCCVEAAAESGGCVMAAATGHPFPRVFSACSRRQLRAFFRKGGGACLSNAPDPGLPVPPALCGNGFVEAGEECDCGPGQECRDLCCFAHNCSLRPGAQCAHGDCCVRCLLKPAGALCRQAMGDCDLPEFCTGTSSHCPPDVYLLDGSPCARGSGYCWDGACPTLEQQCQQLWGPGSHPAPEACFQVVNSAGDAHGNCGQDSEGHFLPCAGRDALCGKLQCQGGKPSLLAPHMVPVDSTVHLDGQEVTCRGALALPSAQLDLLGLGLVEPGTQCGPRMVCQSRRCRKNAFQELQRCLTACHSHGVCNSNHNCHCAPGWAPPFCDKPGFGGSMDSGPVQAENHDTFLLAMLLSVLLPLLPGAGLAWCCYRLPGAHLQRCSWGCRRDPACSGPKDGPHRDHPLGGVHPMELGPTATGQPWPLDPENSHEPSSHPEKPLPAVSPDPQADQVQMPRSCLW
uniprot
proteins
disease_involvement
DISEASE: Asthma (ASTHMA) [MIM:600807]: The most common chronic disease affecting children and young adults. It is a complex genetic disorder with a heterogeneous phenotype, largely attributed to the interactions among many genes and between these genes and the environment. It is characterized by recurrent attacks of paroxysmal dyspnea, with wheezing due to spasmodic contraction of the bronchi. {ECO:0000269|PubMed:12110844, ECO:0000269|PubMed:16773130, ECO:0000269|PubMed:19237393}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.4.24.-
uniprot
proteins
function
FUNCTION: Metalloprotease that cleaves and sheds the ectodomains of cell-surface proteins and thereby contributes to angiogenesis, cell differentiation, inflammation, and cell proliferation (PubMed:14676211, PubMed:33982767). Modulates the activity of adhesion molecules and cytokines by generating soluble forms, leading to either attenuation of cell-surface signaling or initiation of downstream intracellular signaling pathways. For instance, acts as a constitutive sheddase of kit ligand/KITLG (PubMed:14676211). Promotes and maintains a proliferative phenotype in vascular smooth muscle cells through regulation of the PI3K/AKT and ERK signaling pathways (PubMed:33982767). Additionally, enhances cell migration and regulates cytokine secretion during airway vascular remodeling via the same signaling cascades (PubMed:36091328). {ECO:0000269|PubMed:14676211, ECO:0000269|PubMed:33982767, ECO:0000269|PubMed:36091328}.
uniprot
proteins
mass_dalton
87739
uniprot
proteins
mutagenesis
MUTAGEN 346; /note="E->A: Complete loss of catalytic activity."; /evidence="ECO:0000269|PubMed:14676211
uniprot
proteins
post_translational_modification
PTM: The precursor is cleaved by a furin endopeptidase. {ECO:0000250}.
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
11814695
uniprot
proteins
pubmed
12110844
uniprot
proteins
pubmed
12535637
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14659745
uniprot
proteins
pubmed
14676211
uniprot
proteins
pubmed
16773130
uniprot
proteins
pubmed
19237393
uniprot
proteins
pubmed
21618342
uniprot
proteins
pubmed
33982767
uniprot
proteins
pubmed
36091328
uniprot
proteins
sequence_length
813
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12535637}; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 702..722; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins