MSR1
entrez
4481
canonical
uniprot
P21757
canonical
ensembl
ENSG00000038945
resolver
ensp
ENSP00000262100
resolver
ensp
ENSP00000262101
resolver
ensp
ENSP00000371428
resolver
ensp
ENSP00000405453
resolver
enst
ENST00000445506
resolver
genesymbol
MSR1
resolver
genesymbol_syn
SCARA1
resolver
hgnc
HGNC:7376
resolver
uniprot
B4DDJ5
resolver
uniprot
D3DSP3
resolver
uniprot
J3KQP0
resolver
uniprot
O60505
resolver
uniprot
P21759
resolver
uniprot
Q45F10
resolver
uniprot_entry
B4DDJ5_HUMAN
resolver
uniprot_entry
J3KQP0_HUMAN
resolver
uniprot_entry
MSRE_HUMAN
resolver
uniprot_sec
D3DSP3
resolver
uniprot_sec
O60505
resolver
uniprot_sec
P21759
resolver
uniprot_sec
Q45F10
resolver
amino_acid_sequence
MEQWDHFHNQQEDTDSCSESVKFDARSMTALLPPNPKNSPSLQEKLKSFKAALIALYLLVFAVLIPLIGIVAAQLLKWETKNCSVSSTNANDITQSLTGKGNDSEEEMRFQEVFMEHMSNMEKRIQHILDMEANLMDTEHFQNFSMTTDQRFNDILLQLSTLFSSVQGHGNAIDEISKSLISLNTTLLDLQLNIENLNGKIQENTFKQQEEISKLEERVYNVSAEIMAMKEEQVHLEQEIKGEVKVLNNITNDLRLKDWEHSQTLRNITLIQGPPGPPGEKGDRGPTGESGPRGFPGPIGPPGLKGDRGAIGFPGSRGLPGYAGRPGNSGPKGQKGEKGSGNTLTPFTKVRLVGGSGPHEGRVEILHSGQWGTICDDRWEVRVGQVVCRSLGYPGVQAVHKAAHFGQGTGPIWLNEVFCFGRESSIEECKIRQWGTRACSHSEDAGVTCTL
uniprot
proteins
disease_involvement
DISEASE: Prostate cancer (PC) [MIM:176807]: A malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. {ECO:0000269|PubMed:12244320}. Note=The disease may be caused by variants affecting the gene represented in this entry. MSR1 variants may play a role in susceptibility to prostate cancer. MSR1 variants have been found in individuals with prostate cancer and co-segregate with the disease in some families.; DISEASE: Barrett esophagus (BE) [MIM:614266]: A condition characterized by a metaplastic change in which normal esophageal squamous epithelium is replaced by a columnar and intestinal-type epithelium. Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes. {ECO:0000269|PubMed:21791690}. Note=The disease may be caused by variants affecting the gene represented in this entry. Genetic variants in MSR1 have been found in individuals with Barrett esophagus and are thought to contribute to disease susceptibility.
uniprot
proteins
function
FUNCTION: Membrane receptor that mediates the binding, endocytosis and phagocytosis of a broad range of ligands. Recognizes and internalizes modified forms of low-density lipoproteins including acetylated LDL (AcLDL) and oxidized LDL (OxLDL), thereby promoting cholesterol uptake and contributing to foam cell formation during atherogenesis (PubMed:2251254, PubMed:34252459). Binds various pathogen-associated and damage-associated molecules, including bacterial cell wall components, apoptotic cell debris and polyanionic ligands, supporting macrophage clearance activity in innate immune defense (PubMed:10722588). Upon stimulation by CpG DNA, mediates activation of LYN, which phosphorylates SYK that is subsequently recruited to endosomal TLR9 to promote downstream TLR9 signaling (PubMed:29057947, PubMed:40980882). {ECO:0000269|PubMed:10722588, ECO:0000269|PubMed:2251254, ECO:0000269|PubMed:29057947, ECO:0000269|PubMed:34252459, ECO:0000269|PubMed:40980882}.; FUNCTION: [Isoform III]: Does not internalize acetylated LDL. {ECO:0000269|PubMed:9548586}.
uniprot
proteins
mass_dalton
49762
uniprot
proteins
pubmed
10722588
uniprot
proteins
pubmed
12244320
uniprot
proteins
pubmed
14759258
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
21791690
uniprot
proteins
pubmed
2251254
uniprot
proteins
pubmed
25965346
uniprot
proteins
pubmed
29057947
uniprot
proteins
pubmed
34252459
uniprot
proteins
pubmed
40980882
uniprot
proteins
pubmed
8093617
uniprot
proteins
pubmed
8900177
uniprot
proteins
pubmed
9548586
uniprot
proteins
sequence_length
451
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29057947}; Single-pass type II membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 51..76; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins