P35560
uniprot
P35560
canonical
activity_regulation
ACTIVITY REGULATION: Inhibited by WNK3 (By similarity). Activated by phosphatidylinositol 4,5 biphosphate (PtdIns(4,5)P2) (PubMed:9486652). {ECO:0000250|UniProtKB:P48048, ECO:0000269|PubMed:9486652}.
uniprot
proteins
amino_acid_sequence
MGASERSVFRVLIRALTERMFKHLRRWFITHIFGRSRQRARLVSKEGRCNIEFGNVDAQSRFIFFVDIWTTVLDLKWRYKMTVFITAFLGSWFLFGLLWYVVAYVHKDLPEFYPPDNRTPCVENINGMTSAFLFSLETQVTIGYGFRFVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTITPEGETIILDQTNINFVVDAGNENLFFISPLTIYHIIDHNSPFFHMAAETLSQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFVPIVSKTKEGKYRVDFHNFGKTVEVETPHCAMCLYNEKDARARMKRGYDNPNFVLSEVDETDDTQM
uniprot
proteins
function
FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. In the kidney, probably plays a major role in potassium homeostasis. {ECO:0000269|PubMed:7680431, ECO:0000269|PubMed:9015377, ECO:0000269|PubMed:9486652}.; FUNCTION: [Isoform B]: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. {ECO:0000269|PubMed:7611454, ECO:0000269|PubMed:8166245}.; FUNCTION: [Isoform E]: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. {ECO:0000269|PubMed:7611454}.
uniprot
proteins
mass_dalton
44963
uniprot
proteins
mutagenesis
MUTAGEN 188; /note="R->Q: Reduced polyphosphoinositide (PIP2)-binding."; /evidence="ECO:0000269|PubMed:9486652
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane. {ECO:0000250|UniProtKB:P48048}.
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ1 subfamily
uniprot
proteins
pubmed
10069985
uniprot
proteins
pubmed
7611454
uniprot
proteins
pubmed
7680431
uniprot
proteins
pubmed
8166245
uniprot
proteins
pubmed
9015377
uniprot
proteins
pubmed
9486652
uniprot
proteins
sequence_length
391
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P48048}; Multi-pass membrane protein {ECO:0000255}. Note=Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane. {ECO:0000250|UniProtKB:P48048}.
uniprot
proteins
transmembrane_region
TRANSMEM 78..102; /note="Helical; Name=M1"; /evidence="ECO:0000250"; TRANSMEM 156..177; /note="Helical; Name=M2"; /evidence="ECO:0000250
uniprot
proteins