Pmpcb
entrez
73078
canonical
uniprot
Q9CXT8
canonical
ensembl
ENSMUSG00000029017
resolver
ensp
ENSMUSP00000030882
resolver
enst
ENSMUST00000030882
resolver
genesymbol
Pmpcb
resolver
uniprot_entry
MPPB_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Binding to PMPCA is required for catalytic activity. {ECO:0000250|UniProtKB:P10507}.
uniprot
proteins
amino_acid_sequence
MAAAALSRTLLPEARRRLWGFTRRLPLRRAAAQPLYFGGDRLRSTQAAPQVVLNVPETQVTCLENGLRVASENSGLSTCTVGLWIDAGSRYENEKNNGTAHFLEHMAFKGTKKRSQLDLELEIENMGAHLNAYTSREQTVYYAKAFSRDLPRAVEILADIIQNSTLGEAEIERERGVILREMQEVETNLQEVVFDYLHATAYQNTALGRTILGPTENIKSINRKDLVDYITTHYKGPRIVLAAAGGVCHNELLELAKFHFGDSLCSHKGAIPALPPCKFTGSEIRVRDDKMPLAHLAIAVEAVGWAHPDTICLMVANTLIGNWDRSFGGGMNLSSKLAQLTCHGNLCHSFQSFNTSYTDTGLWGLYMVCEQATVADMLHVVQNEWKRLCTDVTESEVARAKNLLKTNMLLQLDGSTPICEDIGRQMLCYNRRIPIPELEARIDAVDAETVRRVCTKYIHDKSPAIAALGPIERLPDFNQICSNMRWIRD
uniprot
proteins
ec_number
3.4.24.64
uniprot
proteins
function
FUNCTION: Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins (By similarity). Preferentially, cleaves after an arginine at position P2 (By similarity). Required for PINK1 turnover by coupling PINK1 mitochondrial import and cleavage, which results in subsequent PINK1 proteolysis (By similarity). {ECO:0000250|UniProtKB:O75439, ECO:0000250|UniProtKB:Q03346}.
uniprot
proteins
mass_dalton
54614
uniprot
proteins
protein_family
Peptidase M16 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
489
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:O75439}.
uniprot
proteins