Mical2
entrez
320878
canonical
uniprot
Q8BML1
canonical
ensembl
ENSMUSG00000038244
resolver
ensp
ENSMUSP00000047639
resolver
ensp
ENSMUSP00000051163
resolver
ensp
ENSMUSP00000102256
resolver
ensp
ENSMUSP00000242750
resolver
ensp
ENSMUSP00000242751
resolver
ensp
ENSMUSP00000242754
resolver
ensp
ENSMUSP00000242755
resolver
genesymbol
Mical2
resolver
genesymbol_syn
Kiaa0750
resolver
genesymbol_syn
Micalcl
resolver
uniprot
B1B545
resolver
uniprot
F6ZD54
resolver
uniprot
F8WJF1
resolver
uniprot
Q14DP1
resolver
uniprot
Q3TR48
resolver
uniprot
Q3UPU6
resolver
uniprot
Q5DU17
resolver
uniprot
Q8CID1
resolver
uniprot
Q9D5U9
resolver
uniprot_entry
MICA2_MOUSE
resolver
uniprot_sec
B1B545
resolver
uniprot_sec
F6ZD54
resolver
uniprot_sec
F8WJF1
resolver
uniprot_sec
Q14DP1
resolver
uniprot_sec
Q3TR48
resolver
uniprot_sec
Q3UPU6
resolver
uniprot_sec
Q5DU17
resolver
uniprot_sec
Q8CID1
resolver
uniprot_sec
Q9D5U9
resolver
amino_acid_sequence
MGENEDEKQAQASQVFENFVQATTCKGTLQAFNILTCLLDLDPLDHRNFYSQLKSKVNTWKAKALWHKLDKRGSHKEYKRGKACSNTKCLIVGGGPCGLRTAIELAYLGAKVVVVEKRDTFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEVHVNVEFVRVLEPPEDQENQKVGWRAEFLPADHALSDFEFDVIIGADGHRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIFNQKFFQDLKEETGIDLENIVYYKDSTHYFVMTAKKQSLLDKGVILNDYIDTEMLLCSENVNQDNLLSYAREAADFATNYQLPSLDFAINHNGQPDVAMFDFTSMYASENAALMRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWDQGTPPLEVLAERESLYRLLPQTTPENINKNFEQYTLDPATRYPNLNLHCVRPHQVKHLYITKEMDRFPLERWGSVRRSVSLSRRESDIRPNKLLTWCQQQTKGYQHVRVTDLTTSWRSGLALCAIIHSFRPELINFDSLNEDDAVENNQLAFDVAKREFGILPVTTGKEMASTQEPDKLSMVMYLSKFYELFRGTPLRPMDSWRKNYGENADFGLGKTFIQNNYLNLTLPRKRTPRVDTQTEENDMNKRRRQGFNHLEELPSFSSRSLGSSQEYAKESGSQNKVKHMANQLLAKFEENTRNPSVVKQDCRRVSGIGKPVLCSASRPPGTSCCPKLEESTPRLPPPLKRQFSSTVATGQVLRELNQVPASGECPSRPWRARAKSDLQLGGVENLATLPRTCQGALALSGVLRRLQQVEEKVLQKRAQNLANREFHTKNIKEKAAHLASMFGHGDLPQDKLLSKRVPHAHPPSPPSCLPSPHPAAASSPPAADSVSPARKVVALNHRLPPPLHLTVGKVSSGIGAAAEVLVNLYLNDHRPKTQATSPDLESPRKAFPLSLGGRDTCYFCKKRVYMIERLSAEGHFFHQECFRCSVCSATLRLAAYAFDCDEGKFYCKPHFVHCKTSSKQRKRRAELNQQREEEGTWQEQEAPRRDVPTESSCAVAAISTPEGSPPDEPISPKKPKSVPEPNPRDVEAEATSPRPSEWTSVRISPGEDTVRQDVLAVRVLVTSEDSSSDTESDYGSITAPCAGAYEERPQLPESPPLSKPLTRHISLRENLTQPVSLLHEEPQALPALQRAHSLQSPTPSKYQNWRRRFQSNSTPMNQRAPSPPKEPPPPPSLSSSSSLPSSFSSASVPGHTADDSSSPQVTYNLHSPQISRGDVSPTPIYLRRARAQGIVKEIPLYLPHSPMLESTEDCLVEPGRESLRSPEEISSSEGCQEARALGNTRSIQHPILGKDQYLPNQNLALGAAGNPGDPREESRMGQPGGPELSKERKLGLKKLVLTEEQKNKLLDWSDCTQEHKTGEQLSQESAENIRGGSLKPTCSSTLSQAVKEKLLSQKKALGGMRTPAVKAPQEREVPPPKSPLKLIANAILRSLLHNSEAGKKTSPKPESKTLPRGQPHARSFSLRKLGSSKDGDQQSPGRHMAKKASAFFSLASPTSKVAQASDLSLPNSILRSRSLPSRPSKMFFSTTPHSKVEDVPTLLEKVSLQDATHSPKTGASHISSLGLKDKSFESFLQECKQRKDIGDFFNSPKEEGPPGNRVPSLEKLVQPVGSTSMGQVAHPSSTGQDARKLEGGEGGSSLVSSLVLVSDPVAPVTEATSSPTSSSAEEEADSQLSLRIKEKILRRRRKLEKQSAKQEELKRLHKAQAIQRQLEEVEERQRTLAIQGVKLEKVLRGEAADSGTQDEAQLLQEWFKLVLEKNKLMRYESELLIMAQELELEDHQSRLEQKLRQKMLKDEGQKDENDLKEEQEIFEEMMQVIEQRNKLVDSLEEQRVKERTQDQHFENFVLSRGCQLSRT
uniprot
proteins
ec_number
1.14.13.225
uniprot
proteins
function
FUNCTION: Methionine monooxygenase that promotes depolymerization of F-actin by mediating oxidation of residues 'Met-44' and 'Met-47' on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:23911929, PubMed:23927065). Regulates the disassembly of branched actin networks also by oxidizing ARP3B-containing ARP2/3 complexes leading to ARP3B dissociation from the network. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA (By similarity). {ECO:0000250|UniProtKB:O94851, ECO:0000250|UniProtKB:Q8TDZ2, ECO:0000269|PubMed:23911929, ECO:0000269|PubMed:23927065}.
uniprot
proteins
mass_dalton
218042
uniprot
proteins
mutagenesis
MUTAGEN 1319..1322; /note="RRAR->AAAA,AAAR,ARAR,RAAR: Abolishes interaction with MAPK1."; /evidence="ECO:0000269|PubMed:18590835
uniprot
proteins
protein_family
Mical family
uniprot
proteins
pubmed
12110185
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18241670
uniprot
proteins
pubmed
18590835
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23911929
uniprot
proteins
pubmed
23927065
uniprot
proteins
sequence_length
1951
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18241670}. Nucleus {ECO:0000250|UniProtKB:O94851}.
uniprot
proteins