GON4L
entrez
54856
canonical
uniprot
Q3T8J9
canonical
ensembl
ENSG00000116580
resolver
ensp
ENSP00000354322
resolver
ensp
ENSP00000357315
resolver
ensp
ENSP00000478593
resolver
ensp
ENSP00000483100
resolver
ensp
ENSP00000522478
resolver
ensp
ENSP00000634046
resolver
genesymbol
GON4L
resolver
genesymbol_syn
GON4
resolver
genesymbol_syn
KIAA1606
resolver
genesymbol_syn
YARP
resolver
hgnc
HGNC:25973
resolver
uniprot
A4PB67
resolver
uniprot
A4PB68
resolver
uniprot
B7ZBL4
resolver
uniprot
Q14BN2
resolver
uniprot
Q14C93
resolver
uniprot
Q3T8J8
resolver
uniprot
Q5VYZ5
resolver
uniprot
Q5W0D5
resolver
uniprot
Q6AWA6
resolver
uniprot
Q6P1Q6
resolver
uniprot
Q7Z3L3
resolver
uniprot
Q8IY79
resolver
uniprot
Q9BQI1
resolver
uniprot
Q9H986
resolver
uniprot
Q9HCG6
resolver
uniprot_entry
A4PB67_HUMAN
resolver
uniprot_entry
A4PB68_HUMAN
resolver
uniprot_entry
GON4L_HUMAN
resolver
uniprot_entry
Q14BN2_HUMAN
resolver
uniprot_entry
Q9H986_HUMAN
resolver
uniprot_sec
B7ZBL4
resolver
uniprot_sec
Q14C93
resolver
uniprot_sec
Q3T8J8
resolver
uniprot_sec
Q5VYZ5
resolver
uniprot_sec
Q5W0D5
resolver
uniprot_sec
Q6AWA6
resolver
uniprot_sec
Q6P1Q6
resolver
uniprot_sec
Q7Z3L3
resolver
uniprot_sec
Q8IY79
resolver
uniprot_sec
Q9BQI1
resolver
uniprot_sec
Q9HCG6
resolver
amino_acid_sequence
MLPCKKRRTTVTESLQHKGNQEENNVDLESAVKPESDQVKDLSSVSLSWDPSHGRVAGFEVQSLQDAGNQLGMEDTSLSSGMLTQNTNVPILEGVDVAISQGITLPSLESFHPLNIHIGKGKLHATGSKRGKKMTLRPGPVTQEDRCDHLTLKEPFSGEPSEEVKEEGGKPQMNSEGEIPSLPSGSQSAKPVSQPRKSTQPDVCASPQEKPLRTLFHQPEEEIEDGGLFIPMEEQDNEESEKRRKKKKGTKRKRDGRGQEGTLAYDLKLDDMLDRTLEDGAKQHNLTAVNVRNILHEVITNEHVVAMMKAAISETEDMPMFEPKMTRSKLKEVVEKGVVIPTWNISPIKKANEIKPPQFVDIHLEEDDSSDEEYQPDDEEEDETAEESLLESDVESTASSPRGAKKSRLRQSSEMTETDEESGILSEAEKVTTPAIRHISAEVVPMGPPPPPKPKQTRDSTFMEKLHAVDEELASSPVCMDSFQPMDDSLIAFRTRSKMPLKDVPLGQLEAELQAPDITPDMYDPNTADDEDWKMWLGGLMNDDVGNEDEADDDDDPEYNFLEDLDEPDTEDFRTDRAVRITKKEVNELMEELFETFQDEMGFSNMEDDGPEEEECVAEPRPNFNTPQALRFEEPLANLLNEQHRTVKELFEQLKMKKSSAKQLQEVEKVKPQSEKVHQTLILDPAQRKRLQQQMQQHVQLLTQIHLLATCNPNLNPEATTTRIFLKELGTFAQSSIALHHQYNPKFQTLFQPCNLMGAMQLIEDFSTHVSIDCSPHKTVKKTANEFPCLPKQVAWILATSKVFMYPELLPVCSLKAKNPQDKIVFTKAEDNLLALGLKHFEGTEFPNPLISKYLLTCKTAHQLTVRIKNLNMNRAPDNIIKFYKKTKQLPVLGKCCEEIQPHQWKPPIEREEHRLPFWLKASLPSIQEELRHMADGAREVGNMTGTTEINSDRSLEKDNLELGSESRYPLLLPKGVVLKLKPVATRFPRKAWRQKRSSVLKPLLIQPSPSLQPSFNPGKTPARSTHSEAPPSKMVLRIPHPIQPATVLQTVPGVPPLGVSGGESFESPAALPAVPPEARTSFPLSESQTLLSSAPVPKVMLPSLAPSKFRKPYVRRRPSKRRGVKASPCMKPAPVIHHPASVIFTVPATTVKIVSLGGGCNMIQPVNAAVAQSPQTIPITTLLVNPTSFPCPLNQSLVASSVSPLIVSGNSVNLPIPSTPEDKAHVNVDIACAVADGENAFQGLEPKLEPQELSPLSATVFPKVEHSPGPPLADAECQEGLSENSACRWTVVKTEEGRQALEPLPQGIQESLNNPTPGDLEEIVKMEPEEAREEISGSPERDICDDIKVEHAVELDTGAPSEELSSAGEVTKQTVLQKEEERSQPTKTPSSSQEPPDEGTSGTDVNKGSSKNALSSMDPEVRLSSPPGKPEDSSSVDGQSVGTPVGPETGGEKNGPEEEEEEDFDDLTQDEEDEMSSASEESVLSVPELQETMEKLTWLASERRMSQEGESEEENSQEENSEPEEEEEEEAEGMESLQKEDEMTDEAVGDSAEKPPTFASPETAPEVETSRTPPGESIKAAGKGRNNHRARNKRGSRARASKDTSKLLLLYDEDILERDPLREQKDLAFAQAYLTRVREALQHIPGKYEDFLQVIYEFESSTQRRTAVDLYKSLQILLQDWPQLLKDFAAFLLPEQALACGLFEEQQAFEKSRKFLRQLEICFAENPSHHQKIIKVLQGCADCLPQEITELKTQMWQLLKGHDHLQDEFSIFFDHLRPAASRMGDFEEINWTEEKEYEFDGFEEVALPDVEEEEEPPKIPTASKNKRKKEIGVQNHDKETEWPDGAKDCACSCHEGGPDSKLKKSKRRSCSHCSSKVCDSKSYKSKEPHELVGSSPHREASPMPGAKEAGQGKDMMEEEAPEERESTEATQSRTVRTTRKGEMPVSAGLAVGSTLPSPREVTVTERLLLDGPPPHSPETPQFPPTTGAVLYTVKRNQVGPEVRSCPKASPRLQKEREGQKAVSESEALMLVWDASETEKLPGTVEPPASFLSPVSSKTRDAGRRHVSGKPDTQERWLPSSRARVKTRDRTCPVHESPSGIDTSETSPKAPRGGLAKDSGTQAKGPEGEQQPKAAEATVCANNSKVSSTGEKVVLWTREADRVILTMCQEQGAQPQTFNIISQQLGNKTPAEVSHRFRELMQLFHTACEASSEDEDDATSTSNADQLSDHGDLLSEEELDE
uniprot
proteins
disease_involvement
DISEASE: Li-Takada-Miyake syndrome (LTMS) [MIM:621212]: An autosomal recessive neurodevelopmental disorder characterized by prenatal-onset growth impairment, developmental delay with intellectual disability and speech delay, microcephaly, cardiac anomalies, and brain abnormalites. {ECO:0000269|PubMed:39500882}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Acts as a key transcription regulator of histones (PubMed:25339177, PubMed:40516528, PubMed:40516529). Activates transcription of the histone H2A, histone H2B, histone H3 and histone H4 genes in conjunction with GON4L and MIZF (PubMed:25339177). Together with CRAMP1, binds to the promoters of H1 genes (H1-2, H1-3, H1-4, H1-5 and H1-10/H1x), driving their transcription (PubMed:40516528, PubMed:40516529). Also acts as a transcription corepressor, as part of a complex with YY1, SIN3A and HDAC1 (By similarity). Required for B-cell lymphopoiesis (By similarity). {ECO:0000250|UniProtKB:Q9DB00, ECO:0000269|PubMed:25339177, ECO:0000269|PubMed:40516528, ECO:0000269|PubMed:40516529}.
uniprot
proteins
mass_dalton
248620
uniprot
proteins
pubmed
10997877
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25339177
uniprot
proteins
pubmed
39500882
uniprot
proteins
pubmed
40516528
uniprot
proteins
pubmed
40516529
uniprot
proteins
sequence_length
2241
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00810}. Chromosome {ECO:0000269|PubMed:25339177, ECO:0000269|PubMed:40516529}. Note=Localizes to histone locus bodies (HLB). {ECO:0000269|PubMed:25339177, ECO:0000269|PubMed:40516529}.
uniprot
proteins