Nqo1
entrez
18104
canonical
uniprot
Q64669
canonical
ensembl
ENSMUSG00000003849
resolver
ensp
ENSMUSP00000003947
resolver
enst
ENSMUST00000003947
resolver
genesymbol
Nqo1
resolver
genesymbol_syn
Dia4
resolver
genesymbol_syn
Nmo1
resolver
genesymbol_syn
Nmor1
resolver
uniprot
Q542Y0
resolver
uniprot_entry
NQO1_MOUSE
resolver
uniprot_entry
Q542Y0_MOUSE
resolver
amino_acid_sequence
MAARRALIVLAHSEKTSFNYAMKEAAVEALKKRGWEVLESDLYAMNFNPIISRNDITGELKDSKNFQYPSESSLAYKEGRLSPDIVAEHKKLEAADLVIFQFPLQWFGVPAILKGWFERVLVAGFAYTYAAMYDNGPFQNKKTLLSITTGGSGSMYSLQGVHGDMNVILWPIQSGILRFCGFQVLEPQLVYSIGHTPPDARMQILEGWKKRLETVWEETPLYFAPSSLFDLNFQAGFLMKKEVQEEQKKNKFGLSVGHHLGKSIPADNQIKARK
uniprot
proteins
ec_number
1.6.5.2
uniprot
proteins
function
FUNCTION: Flavin-containing quinone reductase that catalyzes two-electron reduction of quinones to hydroquinones using either NADH or NADPH as electron donors. In a ping-pong kinetic mechanism, the electrons are sequentially transferred from NAD(P)H to flavin cofactor and then from reduced flavin to the quinone, bypassing the formation of semiquinone and reactive oxygen species (By similarity) (PubMed:8999809). Regulates cellular redox state primarily through quinone detoxification. Reduces components of plasma membrane redox system such as coenzyme Q and vitamin quinones, producing antioxidant hydroquinone forms. In the process may function as superoxide scavenger to prevent hydroquinone oxidation and facilitate excretion (By similarity). Alternatively, can activate quinones and their derivatives by generating redox reactive hydroquinones with DNA cross-linking antitumor potential (By similarity). Acts as a gatekeeper of the core 20S proteasome known to degrade proteins with unstructured regions. Upon oxidative stress, interacts with tumor suppressors TP53 and TP73 in a NADH-dependent way and inhibits their ubiquitin-independent degradation by the 20S proteasome (By similarity). {ECO:0000250|UniProtKB:P05982, ECO:0000250|UniProtKB:P15559, ECO:0000269|PubMed:8999809}.
uniprot
proteins
mass_dalton
30960
uniprot
proteins
protein_family
NAD(P)H dehydrogenase (quinone) family
uniprot
proteins
pubmed
10706635
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7527260
uniprot
proteins
pubmed
7704040
uniprot
proteins
pubmed
8999809
uniprot
proteins
sequence_length
274
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P05982}.
uniprot
proteins