SLC11A1
entrez
6556
canonical
uniprot
P49279
canonical
ensembl
ENSG00000018280
resolver
ensp
ENSP00000233202
resolver
ensp
ENSP00000635667
resolver
ensp
ENSP00000787425
resolver
genesymbol
SLC11A1
resolver
genesymbol_syn
LSH
resolver
genesymbol_syn
NRAMP
resolver
genesymbol_syn
NRAMP1
resolver
hgnc
HGNC:10907
resolver
uniprot
B4DQ73
resolver
uniprot
B9ZVN3
resolver
uniprot
C0H5Y3
resolver
uniprot_entry
B4DQ73_HUMAN
resolver
uniprot_entry
NRAM1_HUMAN
resolver
uniprot_sec
B9ZVN3
resolver
uniprot_sec
C0H5Y3
resolver
amino_acid_sequence
MTGDKGPQRLSGSSYGSISSPTSPTSPGPQQAPPRETYLSEKIPIPDTKPGTFSLRKLWAFTGPGFLMSIAFLDPGNIESDLQAGAVAGFKLLWVLLWATVLGLLCQRLAARLGVVTGKDLGEVCHLYYPKVPRTVLWLTIELAIVGSDMQEVIGTAIAFNLLSAGRIPLWGGVLITIVDTFFFLFLDNYGLRKLEAFFGLLITIMALTFGYEYVVARPEQGALLRGLFLPSCPGCGHPELLQAVGIVGAIIMPHNIYLHSALVKSREIDRARRADIREANMYFLIEATIALSVSFIINLFVMAVFGQAFYQKTNQAAFNICANSSLHDYAKIFPMNNATVAVDIYQGGVILGCLFGPAALYIWAIGLLAAGQSSTMTGTYAGQFVMEGFLRLRWSRFARVLLTRSCAILPTVLVAVFRDLRDLSGLNDLLNVLQSLLLPFAVLPILTFTSMPTLMQEFANGLLNKVVTSSIMVLVCAINLYFVVSYLPSLPHPAYFGLAALLAAAYLGLSTYLVWTCCLAHGATFLAHSSHHHFLYGLLEEDQKGETSG
uniprot
proteins
function
FUNCTION: Antiporter that transports metal ions against a proton gradient, and which promotes host resistance to infection against intracellular parasites, such as M.bovis, S.typhimurium and L.donovani (PubMed:11237855, PubMed:16103355, PubMed:16395392, PubMed:39824808). Plays a key role in pathogen resistance in macrophages by mediating the export of metal ions from the phagosomal compartment, thereby limiting the nutrients available to intracellular pathogens and restricting their growth (By similarity). Also promotes antimicrobial activity in neutrophils against pathogens that survive within phagocytic cells (By similarity). {ECO:0000250|UniProtKB:P41251, ECO:0000269|PubMed:11237855, ECO:0000269|PubMed:16103355, ECO:0000269|PubMed:16395392, ECO:0000269|PubMed:39824808}.
uniprot
proteins
mass_dalton
59872
uniprot
proteins
protein_family
NRAMP (TC 2.A.55) family
uniprot
proteins
pubmed
10967134
uniprot
proteins
pubmed
11237855
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16103355
uniprot
proteins
pubmed
16395392
uniprot
proteins
pubmed
39824808
uniprot
proteins
pubmed
7717395
uniprot
proteins
pubmed
7964458
uniprot
proteins
pubmed
7980580
uniprot
proteins
pubmed
8529098
uniprot
proteins
pubmed
8537108
uniprot
proteins
sequence_length
550
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:P41251}; Multi-pass membrane protein {ECO:0000269|PubMed:39824808}. Late endosome membrane {ECO:0000305|PubMed:11237855}; Multi-pass membrane protein {ECO:0000269|PubMed:39824808}. Lysosome membrane {ECO:0000305|PubMed:11237855}; Multi-pass membrane protein {ECO:0000269|PubMed:39824808}. Note=After onfection, vesicles migrate to the site of bacterial phagosomes. {ECO:0000250|UniProtKB:P41251}.
uniprot
proteins
transmembrane_region
TRANSMEM 61..80; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:39824808, ECO:0007744|PDB:9F6P, ECO:0007744|PDB:9F6Q"; TRANSMEM 93..110; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:39824808, ECO:0007744|PDB:9F6P, ECO:0007744|PDB:9F6Q"; TRANSMEM 132..159; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:39824808, ECO:0007744|PDB:9F6P, ECO:0007744|PDB:9F6Q"; TRANSMEM 170..187; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:39824808, ECO:0007744|PDB:9F6P, ECO:0007744|PDB:9F6Q"; TRANSMEM 191..211; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:39824808, ECO:0007744|PDB:9F6P, ECO:0007744|PDB:9F6Q"; TRANSMEM 241..260; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:39824808, ECO:0007744|PDB:9F6P, ECO:0007744|PDB:9F6Q"; TRANSMEM 284..302; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:39824808, ECO:0007744|PDB:9F6P, ECO:0007744|PDB:9F6Q"; TRANSMEM 362..383; /note="Helical; Name=8"; /evidence="ECO:0000269|PubMed:39824808, ECO:0007744|PDB:9F6P, ECO:0007744|PDB:9F6Q"; TRANSMEM 397..416; /note="Helical; Name=9"; /evidence="ECO:0000269|PubMed:39824808, ECO:0007744|PDB:9F6P, ECO:0007744|PDB:9F6Q"; TRANSMEM 427..447; /note="Helical; Name=10"; /evidence="ECO:0000269|PubMed:39824808, ECO:0007744|PDB:9F6P, ECO:0007744|PDB:9F6Q"; TRANSMEM 462..483; /note="Helical; Name=11"; /evidence="ECO:0000269|PubMed:39824808, ECO:0007744|PDB:9F6P, ECO:0007744|PDB:9F6Q"; TRANSMEM 497..519; /note="Helical; Name=12"; /evidence="ECO:0000269|PubMed:39824808, ECO:0007744|PDB:9F6P, ECO:0007744|PDB:9F6Q
uniprot
proteins