TRIM48
entrez
79097
canonical
uniprot
Q8IWZ4
canonical
ensembl
ENSG00000150244
resolver
ensp
ENSP00000402414
resolver
enst
ENST00000417545
resolver
genesymbol
TRIM48
resolver
genesymbol_syn
RNF101
resolver
hgnc
HGNC:19021
resolver
uniprot
Q9BUW4
resolver
uniprot_entry
TRI48_HUMAN
resolver
uniprot_sec
Q9BUW4
resolver
amino_acid_sequence
MSRRIIVGTLQRTQRNMNSGISQVFQRELTCPICMNYFIDPVTIDCGHSFCRPCFYLNWQDIPILTQCFECIKTIQQRNLKTNIRLKKMASLARKASLWLFLSSEEQMCGIHRETKKMFCEVDRSLLCLLCSSSQEHRYHRHCPAEWAAEEHWEKLLKKMQSLWEKACENQRNLNVETTRISHWKAFGDILYRSESVLLHMPQPLNLALRAGPITGLRDRLNQF
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase which promotes K48-linked polyubiquitination of protein methyltransferase PRMT1, leading to PRMT1 degradation (PubMed:29186683). This suppresses methylation of the PRMT1 substrate MAP3K5/ASK1, promoting its activation and increasing MAP3K5-dependent cell death induced by oxidative stress (PubMed:29186683). TRIM48-mediated ubiquitination of PRMT1 also suppresses methylation of FOXO1 by PRMT1, leading to inhibition of FOXO1 transcriptional activity (PubMed:29186683). Additionally, it inhibits RIG-I-mediated antiviral signaling, functioning as an inducible negative feedback regulator of this pathway (PubMed:40609779). {ECO:0000269|PubMed:29186683, ECO:0000269|PubMed:40609779}.
uniprot
proteins
mass_dalton
26409
uniprot
proteins
mutagenesis
MUTAGEN 46; /note="C->S: Abolishes PRMT1 ubiquitination and MAP3K5 activation."; /evidence="ECO:0000269|PubMed:29186683
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
29186683
uniprot
proteins
pubmed
40609779
uniprot
proteins
sequence_length
224
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:29186683}.
uniprot
proteins