Rbm47
entrez
245945
canonical
uniprot
Q91WT8
canonical
ensembl
ENSMUSG00000070780
resolver
ensp
ENSMUSP00000092348
resolver
ensp
ENSMUSP00000092349
resolver
ensp
ENSMUSP00000109355
resolver
ensp
ENSMUSP00000128016
resolver
ensp
ENSMUSP00000144325
resolver
ensp
ENSMUSP00000342496
resolver
enst
ENSMUST00000094756
resolver
genesymbol
Rbm47
resolver
uniprot
D3YXZ5
resolver
uniprot
Q3UQC7
resolver
uniprot
Q8BZE8
resolver
uniprot_entry
D3YXZ5_MOUSE
resolver
uniprot_entry
RBM47_MOUSE
resolver
uniprot_sec
Q3UQC7
resolver
uniprot_sec
Q8BZE8
resolver
amino_acid_sequence
MTAEDSATAMNSDPTVGSSTKVPEGVAGAPNEAALLALIERTGYTMVQENGQRKYGGPPPGWEGPHPQRGCEVFVGKIPRDVYEDELVPVFETVGRIYELRLMMDFDGKNRGYAFVMYCHKHEAKRAVRELNNYEIRPGRLLGVCCSVDNCRLFIGGIPKMKKRGEILEEIAKVTEGVLNVIVYASAADKMKNRGFAFVEYESHRAAAMARRKLMPGRIQLWGHQIAVDWAEPEIDVDEDVMQTVKILYVRNLMIETTEETIKKSFGQFNPGCVERVKKIRDYAFVHFTSREDAVHAMNNLNGTELEGSCLEVTLAKPVDKEQYSRYQKAAKGGGGSAEAVAQQPSYVYSCDPYTLAYYGYPYNALIGPNRDYFVKTGSIRGRGRGAAGNRTPGPRGSYLGGYSAGRGIYSRYHEGKGKQQEKGYELVPNLEISPVNPVAIKPGTVAIPAIGAQYSMFQAAPAPKIIEDGKIHTMEHMISPIAVQPDPATAAAAAAAAAAAAVIPAVSTPPPFQGRPITPVYTVAPNVQRIPTAGIYGASYVPFAAPATATIATLQKNAAAAVYGGYAGYIPQAFPAALQVPIHDVYQTY
uniprot
proteins
function
FUNCTION: Single-stranded RNA-binding protein that functions in a variety of RNA processes, including alternative splicing, RNA stabilization, and RNA editing. Functions as an enzyme-substrate adapter for the cytidine deaminase APOBEC1. With APOBEC1 forms an mRNA editing complex involved into cytidine to uridine editing of a variety of mRNA molecules (PubMed:24916387, PubMed:30309881, PubMed:30844405). Through the binding of their 3'UTR, also stabilizes a variety of mRNAs and regulates the expression of genes such as the interferon alpha/beta receptor and interleukin-10 (PubMed:29844590). Also involved in the alternative splicing of several genes including TJP1. Binds the pre-mRNA (U)GCAUG consensus sequences in downstream intronic regions of alternative exons, regulating their exclusion and inclusion into mRNAs (By similarity). Independently of its RNA-binding activity, could negatively regulate MAVS by promoting its lysosomal degradation (By similarity). {ECO:0000250|UniProtKB:A0A8M1NHK4, ECO:0000250|UniProtKB:A0AV96, ECO:0000269|PubMed:24916387, ECO:0000269|PubMed:29844590, ECO:0000269|PubMed:30309881, ECO:0000269|PubMed:30844405}.
uniprot
proteins
mass_dalton
64062
uniprot
proteins
protein_family
RRM RBM47 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24916387
uniprot
proteins
pubmed
29844590
uniprot
proteins
pubmed
30309881
uniprot
proteins
pubmed
30844405
uniprot
proteins
sequence_length
590
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:A0AV96}. Cytoplasm {ECO:0000250|UniProtKB:A0AV96}.
uniprot
proteins