SLC26A1
entrez
10861
canonical
uniprot
Q9H2B4
canonical
ensembl
ENSG00000145217
resolver
ensp
ENSP00000354721
resolver
ensp
ENSP00000381528
resolver
ensp
ENSP00000381532
resolver
genesymbol
SLC26A1
resolver
genesymbol_syn
SAT1
resolver
hgnc
HGNC:10993
resolver
uniprot
A8K9N2
resolver
uniprot
Q7Z5R3
resolver
uniprot
Q96BK0
resolver
uniprot_entry
S26A1_HUMAN
resolver
uniprot_sec
A8K9N2
resolver
uniprot_sec
Q7Z5R3
resolver
uniprot_sec
Q96BK0
resolver
amino_acid_sequence
MDESPEPLQQGRGPVPVRRQRPAPRGLREMLKARLWCSCSCSVLCVRALVQDLLPATRWLRQYRPREYLAGDVMSGLVIGIILVPQAIAYSLLAGLQPIYSLYTSFFANLIYFLMGTSRHVSVGIFSLLCLMVGQVVDRELQLAGFDPSQDGLQPGANSSTLNGSAAMLDCGRDCYAIRVATALTLMTGLYQVLMGVLRLGFVSAYLSQPLLDGFAMGASVTILTSQLKHLLGVRIPRHQGPGMVVLTWLSLLRGAGQANVCDVVTSTVCLAVLLAAKELSDRYRHRLRVPLPTELLVIVVATLVSHFGQLHKRFGSSVAGDIPTGFMPPQVPEPRLMQRVALDAVALALVAAAFSISLAEMFARSHGYSVRANQELLAVGCCNVLPAFLHCFATSAALAKSLVKTATGCRTQLSSVVSATVVLLVLLALAPLFHDLQRSVLACVIVVSLRGALRKVWDLPRLWRMSPADALVWAGTAATCMLVSTEAGLLAGVILSLLSLAGRTQRPRTALLARIGDTAFYEDATEFEGLVPEPGVRVFRFGGPLYYANKDFFLQSLYSLTGLDAGCMAARRKEGGSETGVGEGGPAQGEDLGPVSTRAALVPAAAGFHTVVIDCAPLLFLDAAGVSTLQDLRRDYGALGISLLLACCSPPVRDILSRGGFLGEGPGDTAEEEQLFLSVHDAVQTARARHRELEATDAHL
uniprot
proteins
disease_involvement
DISEASE: Nephrolithiasis, calcium oxalate, 1 (CAON1) [MIM:167030]: A form of nephrolithiasis, a condition in which urinary supersaturation leads to stone formation in the urinary system. Patients manifest acute renal colic with severe pain originating in the flank. Patients with small, non-obstructing stones or those with staghorn calculi may be asymptomatic. The majority of renal calculi contain calcium. CAON1 is characterized by calcium oxalate kidney stones. {ECO:0000269|PubMed:27210743, ECO:0000269|PubMed:36719378}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Hypersulfaturia (HYSULF) [MIM:620372]: An autosomal recessive inborn error of sulfate homeostasis resulting in urinary sulfate wasting and low plasma sulfate. Clinical features include costochondritis, perichondritis of the costovertebral joints, and chest pain. {ECO:0000269|PubMed:36719378}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Sodium-independent sulfate anion transporter (PubMed:12713736, PubMed:27125215). Can transport other anions including bicarbonate, thiosulfate and oxalate by mediating sulfate-thiosulfate, sulfate-hydrogencarbonate and sulfate-oxalate anion exchange (PubMed:12713736, PubMed:27125215). Mediates oxalate-hydrogencarbonate anion exchange (By similarity). {ECO:0000250|UniProtKB:P58735, ECO:0000269|PubMed:12713736, ECO:0000269|PubMed:27125215}.
uniprot
proteins
mass_dalton
75016
uniprot
proteins
protein_family
SLC26A/SulP transporter (TC 2.A.53) family
uniprot
proteins
pubmed
11087667
uniprot
proteins
pubmed
12713736
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27125215
uniprot
proteins
pubmed
27210743
uniprot
proteins
pubmed
36719378
uniprot
proteins
sequence_length
701
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P58735}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:P45380}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 68..90; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 94..116; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 176..198; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 255..277; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 290..309; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 342..364; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 377..399; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 412..434; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 472..494; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins