Siae
entrez
22619
canonical
uniprot
P70665
canonical
ensembl
ENSMUSG00000001942
resolver
ensp
ENSMUSP00000149505
resolver
genesymbol
Siae
resolver
genesymbol_syn
Ysg2
resolver
uniprot
Q3TNZ5
resolver
uniprot
Q544V7
resolver
uniprot
Q61044
resolver
uniprot
Q8C902
resolver
uniprot
Q8CBM6
resolver
uniprot
Q8CC41
resolver
uniprot
Q8CEB7
resolver
uniprot
Q922L0
resolver
uniprot_entry
SIAE_MOUSE
resolver
uniprot_sec
Q3TNZ5
resolver
uniprot_sec
Q544V7
resolver
uniprot_sec
Q61044
resolver
uniprot_sec
Q8C902
resolver
uniprot_sec
Q8CBM6
resolver
uniprot_sec
Q8CC41
resolver
uniprot_sec
Q8CEB7
resolver
uniprot_sec
Q922L0
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by diisopropyl fluorophosphate and diethyl-P-nitrophenyl phosphate. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MVSPGPVFGIVLLIIARVSRSAGIGFRFASYIDNYMVLQKEPSGAVIWGFGTPGATVTVTLCQGQETIMKKVTSVKEPSNTWMVVLDPMKPGGPFEVMAQQTLGTMNFTLRVHDVLFGDVWLCSGQSNMQMTVSQIFNASKELSDTAAYQSVRIFSVSLIQSEEELDDLTEVDLSWSKPTAGNLGHGNFTYMSAVCWLFGRYLYDTLQYPIGLVSSSWGGTYIEVWSSRRTLKACGVPNTRDERVGQPEIKPMRNECNSEESSCPFRVVPSVRVTGPTRHSVLWNAMIHPLQNMTLKGVVWYQGESNADYNRDLYTCMFPELIEDWRQTFHYGSQGQTDRFFPFGFVQLSSYMLKNSSDYGFPEIRWHQTADFGHVPNPKMPNTFMAVAIDLCDRDSPFGSIHPRDKQTVAYRLHLGARAVAYGEKNLTFQGPLPKKIELLASNGLLNLTYDQEIQVQMQDNKTFEISCCSDRHCKWLPAPVNTFSTQTLILDLNACLGTVVAVRYAWTTWPCEYKQCAVYHTSSMLPAPPFIAQISHRGI
uniprot
proteins
ec_number
3.1.1.53
uniprot
proteins
function
FUNCTION: Catalyzes the removal of O-acetyl ester groups from position 9 of the free diacetylated sialate N-acetyl-9-O-acetylneuraminate (Neu5,9Ac2) in the cytosol and of the diacetylated sialate residues of sialylglycoconjugates in the lysosomes (Probable) (PubMed:8662838). Together with the sialate-O-acetyltransferase they regulate the balance of acetylated sialoglycoconjugates, key players in various processes such as cell-cell interactions, host-pathogen recognition, and tumor antigenicity (Probable). {ECO:0000269|PubMed:8662838, ECO:0000305|PubMed:10464298, ECO:0000305|PubMed:23308225, ECO:0000305|PubMed:8662838}.
uniprot
proteins
mass_dalton
60775
uniprot
proteins
post_translational_modification
PTM: The two subunits are derived from a single precursor by proteolytic cleavage. {ECO:0000250}.; PTM: The lysosomal isoform is glycosylated.
uniprot
proteins
pubmed
10464298
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23308225
uniprot
proteins
pubmed
8662838
uniprot
proteins
pubmed
8918804
uniprot
proteins
sequence_length
541
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Lysosome {ECO:0000269|PubMed:10464298}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:10464298}.
uniprot
proteins