RHCG
entrez
51458
canonical
uniprot
Q9UBD6
canonical
ensembl
ENSG00000140519
resolver
ensp
ENSP00000268122
resolver
ensp
ENSP00000579262
resolver
ensp
ENSP00000579264
resolver
ensp
ENSP00000610812
resolver
enst
ENST00000268122
resolver
enst
ENST00000909203
resolver
enst
ENST00000909205
resolver
enst
ENST00000940753
resolver
genesymbol
RHCG
resolver
genesymbol_syn
C15orf6
resolver
genesymbol_syn
CDRC2
resolver
genesymbol_syn
PDRC2
resolver
genesymbol_syn
RHGK
resolver
hgnc
HGNC:18140
resolver
uniprot
A8K4D4
resolver
uniprot
Q6X3Y4
resolver
uniprot_entry
RHCG_HUMAN
resolver
uniprot_sec
A8K4D4
resolver
uniprot_sec
Q6X3Y4
resolver
amino_acid_sequence
MAWNTNLRWRLPLTCLLLQVIMVILFGVFVRYDFEADAHWWSERTHKNLSDMENEFYYRYPSFQDVHVMVFVGFGFLMTFLQRYGFSAVGFNFLLAAFGIQWALLMQGWFHFLQDRYIVVGVENLINADFCVASVCVAFGAVLGKVSPIQLLIMTFFQVTLFAVNEFILLNLLKVKDAGGSMTIHTFGAYFGLTVTRILYRRNLEQSKERQNSVYQSDLFAMIGTLFLWMYWPSFNSAISYHGDSQHRAAINTYCSLAACVLTSVAISSALHKKGKLDMVHIQNATLAGGVAVGTAAEMMLMPYGALIIGFVCGIISTLGFVYLTPFLESRLHIQDTCGINNLHGIPGIIGGIVGAVTAASASLEVYGKEGLVHSFDFQGFNGDWTARTQGKFQIYGLLVTLAMALMGGIIVGLILRLPFWGQPSDENCFEDAVYWEMPEGNSTVYIPEDPTFKPSGPSVPSVPMVSPLPMASSVPLVP
uniprot
proteins
function
FUNCTION: Ammonium transporter involved in the maintenance of acid-base homeostasis. Transports ammonium and its related derivative methylammonium across the plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism. Postulated to primarily mediate an electroneutral bidirectional transport of NH3 ammonia species according to a mechanism that implies interaction of an NH4(+) ion with acidic residues of the pore entry followed by dissociation of NH4(+) into NH3 and H(+). As a result NH3 transits through the central pore and is protonated on the extracellular side reforming NH4(+) (PubMed:11062476, PubMed:14761968, PubMed:15929723, PubMed:16477434, PubMed:16580862, PubMed:24077989). May act as a CO2 channel providing for renal acid secretion (PubMed:24077989). {ECO:0000269|PubMed:11062476, ECO:0000269|PubMed:14761968, ECO:0000269|PubMed:15929723, ECO:0000269|PubMed:16477434, ECO:0000269|PubMed:16580862, ECO:0000269|PubMed:24077989}.
uniprot
proteins
mass_dalton
53179
uniprot
proteins
mutagenesis
MUTAGEN 74; /note="F->L: Reduction of ammonia transport."; /evidence="ECO:0000269|PubMed:16580862"; MUTAGEN 137; /note="V->I: Reduction of ammonia transport."; /evidence="ECO:0000269|PubMed:16580862"; MUTAGEN 177; /note="D->N: Loss of function."; /evidence="ECO:0000269|PubMed:16477434, ECO:0000269|PubMed:24077989"; MUTAGEN 235; /note="F->V: Reduction of ammonia transport."; /evidence="ECO:0000269|PubMed:16580862
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:10852913, ECO:0000269|PubMed:20457942}.
uniprot
proteins
protein_family
Ammonium transporter (TC 2.A.49) family
uniprot
proteins
protein_family
Rh subfamily
uniprot
proteins
pubmed
10852913
uniprot
proteins
pubmed
11062476
uniprot
proteins
pubmed
12204676
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14761968
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15929723
uniprot
proteins
pubmed
16477434
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
16580862
uniprot
proteins
pubmed
20457942
uniprot
proteins
pubmed
24077989
uniprot
proteins
sequence_length
479
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15929723}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:10852913, ECO:0000269|PubMed:12204676}; Multi-pass membrane protein {ECO:0000255}. Note=Also detected at the basolateral membrane and in subapical vesicles. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..30; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 61..81; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 86..106; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 124..144; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 149..169; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 178..200; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 219..239; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 251..271; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 282..302; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 304..324; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 346..366; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 395..415; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins