Clpb
entrez
65041
canonical
uniprot
Q9WTT2
canonical
ensembl
ENSRNOG00000019693
resolver
ensp
ENSRNOP00000026665
resolver
ensp
ENSRNOP00000072796
resolver
enst
ENSRNOT00000079846
resolver
genesymbol
Clpb
resolver
genesymbol_syn
Skd3
resolver
uniprot
A0A0G2K3V9
resolver
uniprot
F1M955
resolver
uniprot
Q6IRH7
resolver
uniprot_entry
A0A0G2K3V9_RAT
resolver
uniprot_entry
CLPB_RAT
resolver
uniprot_entry
Q6IRH7_RAT
resolver
uniprot_sec
F1M955
resolver
activity_regulation
ACTIVITY REGULATION: Disaggregase activity is inhibited by ADP. {ECO:0000250|UniProtKB:Q9H078}.
uniprot
proteins
amino_acid_sequence
MMLSAVLRRTAPAPRLFLGLIKSPSLQSRGGAYNRSVITGDRGEPQRLRTAAWVRPGASSVLFPGRGAATGGRRGERTEIPYLTAASSGRGPSPEETLPGQDSWNGVPNKAGLGMWALAMALVVQCYNKNPSNKDAALMEAARANNVQEVRRLLSEGADVNARHKLGWTALMVAAISHNESVVQVLLAAGADPNLGDDFSSVYKTANEQGVHSLEVLVTREDDFNNRLNHRASFKGCTALHYAVLADDYSIVKELLGGGANPLQRNEMGHTPLDYAREGEVMKLLKTSETKYMEKQRKREAEERRRFPLEQRLEQHIIGQESAIATVGAAIRRKENGWYDEEHPLVFLFLGSSGIGKTELAKQTAKYMHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYIGHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQLFDEGRLTDGKGKTIDCKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDVQISDKITISKNFKENMIRPILKAHFRRDEFLGRINEIVYFLPFCHSELIQLVNKELNFWAKRAKQRHNITLLWDREVADVLVDGYNVQYGARSIKHEVERRVVNQLAAAYEQDLLPGGCTLRITVEDSDKQLLKSPELPSPQAEKRPPTLRLEIIDKDSKTHKLDIQAPLHPEKVCYTI
uniprot
proteins
ec_number
3.6.1.-
uniprot
proteins
function
FUNCTION: Functions as a regulatory ATPase and participates in secretion/protein trafficking process. Has ATP-dependent protein disaggregase activity and is required to maintain the solubility of key mitochondrial proteins. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6. Plays a role in granulocyte differentiation. {ECO:0000250|UniProtKB:Q9H078}.
uniprot
proteins
mass_dalton
75702
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved by protease PARL. ATP-dependent protein disaggregase activity is stimulated by PARL-mediated cleavage of the N-terminal autoinhibitory peptide. {ECO:0000250|UniProtKB:Q9H078}.
uniprot
proteins
protein_family
ClpA/ClpB family
uniprot
proteins
sequence_length
677
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000250|UniProtKB:Q9H078}.
uniprot
proteins