CCT6A
entrez
908
canonical
uniprot
P40227
canonical
ensembl
ENSG00000146731
resolver
ensp
ENSP00000275603
resolver
ensp
ENSP00000352019
resolver
genesymbol
CCT6A
resolver
genesymbol_syn
CCT6
resolver
genesymbol_syn
CCTZ
resolver
hgnc
HGNC:1620
resolver
uniprot
A6NCD2
resolver
uniprot
Q3KP28
resolver
uniprot
Q75LP4
resolver
uniprot
Q96S46
resolver
uniprot_entry
TCPZ_HUMAN
resolver
uniprot_sec
A6NCD2
resolver
uniprot_sec
Q3KP28
resolver
uniprot_sec
Q75LP4
resolver
uniprot_sec
Q96S46
resolver
amino_acid_sequence
MAAVKTLNPKAEVARAQAALAVNISAARGLQDVLRTNLGPKGTMKMLVSGAGDIKLTKDGNVLLHEMQIQHPTASLIAKVATAQDDITGDGTTSNVLIIGELLKQADLYISEGLHPRIITEGFEAAKEKALQFLEEVKVSREMDRETLIDVARTSLRTKVHAELADVLTEAVVDSILAIKKQDEPIDLFMIEIMEMKHKSETDTSLIRGLVLDHGARHPDMKKRVEDAYILTCNVSLEYEKTEVNSGFFYKSAEEREKLVKAERKFIEDRVKKIIELKRKVCGDSDKGFVVINQKGIDPFSLDALSKEGIVALRRAKRRNMERLTLACGGVALNSFDDLSPDCLGHAGLVYEYTLGEEKFTFIEKCNNPRSVTLLIKGPNKHTLTQIKDAVRDGLRAVKNAIDDGCVVPGAGAVEVAMAEALIKHKPSVKGRAQLGVQAFADALLIIPKVLAQNSGFDLQETLVKIQAEHSESGQLVGVDLNTGEPMVAAEVGVWDNYCVKKQLLHSCTVIATNILLVDEIMRAGMSSLKG
uniprot
proteins
disease_involvement
DISEASE: Note=De novo genetic variants in nearly every subunit of the TRiC complex, including CCT6A, have been found in individuals with a broad spectrum of brain malformations, and clinical phenotypes ranging from mild to severe epilepsy, developmental delay, intellectual disability, ataxia, and other features of cerebral malfunction. {ECO:0000269|PubMed:39480921}.
uniprot
proteins
ec_number
3.6.1.-
uniprot
proteins
function
FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). {ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}.
uniprot
proteins
mass_dalton
58024
uniprot
proteins
protein_family
TCP-1 chaperonin family
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
1352881
uniprot
proteins
pubmed
14532270
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25467444
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
35449234
uniprot
proteins
pubmed
36493755
uniprot
proteins
pubmed
37193829
uniprot
proteins
pubmed
39480921
uniprot
proteins
pubmed
8034610
uniprot
proteins
sequence_length
531
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8034610}.
uniprot
proteins