CLVS1
entrez
157807
canonical
uniprot
Q8IUQ0
canonical
ensembl
ENSG00000177182
resolver
ensp
ENSP00000325506
resolver
ensp
ENSP00000428402
resolver
genesymbol
CLVS1
resolver
genesymbol_syn
CRALBPL
resolver
genesymbol_syn
RLBP1L1
resolver
hgnc
HGNC:23139
resolver
uniprot
B2R7M5
resolver
uniprot
C8UZT3
resolver
uniprot
Q8NB32
resolver
uniprot_entry
CLVS1_HUMAN
resolver
uniprot_sec
B2R7M5
resolver
uniprot_sec
C8UZT3
resolver
uniprot_sec
Q8NB32
resolver
amino_acid_sequence
MGPVSLLPKYQKLNTWNGDLAKMTHLQAGLSPETIEKARLELNENPDVLHQDIQQVRDMIITRPDIGFLRTDDAFILRFLRARKFHQADAFRLLAQYFQYRQLNLDMFKNFKADDPGIKRALIDGFPGVLENRDHYGRKILLLFAANWDQSRNSFTDILRAILLSLEVLIEDPELQINGFILIIDWSNFSFKQASKLTPSILKLAIEGLQDSFPARFGGVHFVNQPWYIHALYTLIKPFLKDKTRKRIFLHGNNLNSLHQLIHPEFLPSEFGGTLPPYDMGTWARTLLGPDYSDENDYTHTSYNAMHVKHTSSNLERECSPKLMKRSQSVVEAGTLKHEEKGENENTQPLLALD
uniprot
proteins
function
FUNCTION: Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). {ECO:0000250, ECO:0000269|PubMed:19651769}.
uniprot
proteins
mass_dalton
40788
uniprot
proteins
mutagenesis
MUTAGEN 83..85; /note="RKF->AAA: Abolishes binding to PtdIns(3,5)P2. No effect on subcellular location."; /evidence="ECO:0000269|PubMed:19651769
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16802092
uniprot
proteins
pubmed
19651769
uniprot
proteins
sequence_length
354
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250}. Early endosome membrane {ECO:0000269|PubMed:19651769}; Peripheral membrane protein {ECO:0000269|PubMed:19651769}.
uniprot
proteins