EEIG1
entrez
399665
canonical
uniprot
Q5T9C2
canonical
ensembl
ENSG00000167106
resolver
ensp
ENSP00000362176
resolver
ensp
ENSP00000362187
resolver
genesymbol
EEIG1
resolver
genesymbol_syn
C9orf132
resolver
genesymbol_syn
FAM102A
resolver
hgnc
HGNC:31419
resolver
uniprot
A2A329
resolver
uniprot
Q8TEL4
resolver
uniprot_entry
EEIG1_HUMAN
resolver
uniprot_sec
A2A329
resolver
uniprot_sec
Q8TEL4
resolver
amino_acid_sequence
MAFLMKKKKFKFQTTFTLEELTAVPFVNGVLFCKVRLLDGGDFVSLSSREEVQENCVRWRKRFTFVCKMSANPATGLLDPCVFRVSVRKELKGGKAYSKLGFADLNLAEFAGSGSTVRCCLLEGYDTKNTRQDNSILKVTIGMFLLSGDPCFKTPPSTAKSISIPGQDSSLQLTCKGGGTSSGGSSTNSLTGSRPPKARPTILSSGLPEEPDQNLSSPEEVFHSGHSRNSSYASQQSKISGYSTEHSRSSSLSDLTHRRNTSTSSSASGGLGMTVEGPEGSEREHRPPEKPPRPPRPLHLSDRSFRRKKDSVESHPTWVDDTRIDADAIVEKIVQSQDFTDGSNTEDSNLRLFVSRDGSATLSGIQLATRVSSGVYEPVVIESH
uniprot
proteins
function
FUNCTION: Key component of TNFSF11/RANKL- and TNF-induced osteoclastogenesis pathways, thereby mediates bone resorption in pathological bone loss conditions (By similarity). Required for TNFSF11/RANKL-induced osteoclastogenesis via its interaction with TNFRSF11A/RANK, thereby facilitates the downstream transcription of NFATC1 and activation of PLCG2 (By similarity). Facilitates recruitment of the transcriptional repressor PRDM1/BLIMP1 to the promoter of the anti-osteoclastogenesis gene IRF8, thereby resulting in transcription of osteoclast differentiation factors (By similarity). May play a role in estrogen action (PubMed:14605097). {ECO:0000250|UniProtKB:Q78T81, ECO:0000269|PubMed:14605097}.
uniprot
proteins
mass_dalton
41785
uniprot
proteins
protein_family
EEIG family
uniprot
proteins
pubmed
14605097
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
384
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q78T81}. Cytoplasm {ECO:0000250|UniProtKB:Q78T81}. Membrane raft {ECO:0000250|UniProtKB:Q78T81}.
uniprot
proteins