Septin12
entrez
71089
canonical
uniprot
A0A2R8VJU7
canonical
ensembl
ENSMUSG00000022542
resolver
ensp
ENSMUSP00000131062
resolver
ensp
ENSMUSP00000154901
resolver
ensp
ENSMUSP00000155459
resolver
ensp
ENSMUSP00000354260
resolver
ensp
ENSMUSP00000354261
resolver
enst
ENSMUST00000170323
resolver
enst
ENSMUST00000229321
resolver
enst
ENSMUST00000230362
resolver
genesymbol
Septin12
resolver
genesymbol_syn
Sept12
resolver
uniprot
A0A2R8VKF7
resolver
uniprot
F7AJP9
resolver
uniprot
Q9D451
resolver
uniprot
Q9D9U8
resolver
uniprot_entry
A0A2R8VKF7_MOUSE
resolver
uniprot_entry
F7AJP9_MOUSE
resolver
uniprot_entry
SEP12_MOUSE
resolver
uniprot_sec
Q9D451
resolver
uniprot_sec
Q9D9U8
resolver
amino_acid_sequence
MDERRSPSPCSSRPSSPRTPPNEMFGPVGIEAVLDQLRIKAMKTGFEFNIMVVGQSGLGKSTMVNTLFKSKVWQSTEPNLDVPMPQTLELHSVTHVIEEKGLKLKLTVTDTPGFGDQINNDKCWDPILSYINQQYEQYLQEELLITRQRHIPDTRVHCCVYFVPPTGHCLRPLDIEFLRRLCRTVNVVPVIARADSLTIEERDAFRSRIQQNLKTHCIDVYPQKCFDEDVNDRLLNSKIREQIPFAVVGADREHIVNGRCVLGRKTKWGIIEVENMAHCEFLLLRDLLIRSHLQDLKDITHNVHYENYRVLRLNESHVLPRGPGWVNLAPVSPGQLMAPGPGKVRKRANKDTKDEEC
uniprot
proteins
function
FUNCTION: Filament-forming cytoskeletal GTPase (By similarity). Involved in the morphogenesis of sperm heads and the elongation of sperm tails probably implicating the association with alpha- and beta-tubulins (By similarity). Facilitates the formation of Septin filament structures with SEPTIN7, SEPTIN6, SEPTIN2 and SEPTIN4 at the sperm annulus (PubMed:25588830, PubMed:28346465). Correct formation of the annulus is required for development of normal structural morphology and motility of the sperm during steps 13 to 16 of spermiogenesis (PubMed:25588830, PubMed:28346465). Essential component of the LMNB1/SUN5/SEPT12 bridge that connects the sperm proximal centriole to the implantation fossa, the bridge functions to prevent detachment of the proximal centriole from the posterior nucleus during steps 13 to 16 of spermiogenesis (PubMed:38870534). Required for PLCZ1 localization at the sperm acrosome during spermiogenesis (PubMed:35547809). May also play a role in the initiation of calcium oscillations in embryos (PubMed:35547809). {ECO:0000250|UniProtKB:Q8IYM1, ECO:0000250|UniProtKB:Q9NVA2, ECO:0000269|PubMed:25588830, ECO:0000269|PubMed:28346465, ECO:0000269|PubMed:35547809, ECO:0000269|PubMed:38870534}.
uniprot
proteins
mass_dalton
40875
uniprot
proteins
mutagenesis
MUTAGEN 195; /note="D->N: Loss of expression of SEPTIN2, SEPTIN6 and SEPTIN7 in sperm resulting in reduced motility and abnormal morphology, including defective annulus and bent tails."; /evidence="ECO:0000269|PubMed:25588830"; MUTAGEN 196; /note="S->E: Abolishes annulus formation due to loss of initial assembly of the Septin ring complex in spermatozoa, which show abnormal morphology and reduced motility. Reduces male fertility."; /evidence="ECO:0000269|PubMed:28346465
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-196; by PRKACA; results in inhibition of Septin ring formation and as a result annulus formation during spermiogenesis. {ECO:0000269|PubMed:28346465}.
uniprot
proteins
protein_family
Septin GTPase family
uniprot
proteins
protein_family
TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
25588830
uniprot
proteins
pubmed
28346465
uniprot
proteins
pubmed
30189608
uniprot
proteins
pubmed
35547809
uniprot
proteins
pubmed
38870534
uniprot
proteins
sequence_length
357
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8IYM1}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q8IYM1}. Nucleus {ECO:0000250|UniProtKB:Q8IYM1}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:25588830, ECO:0000269|PubMed:28346465, ECO:0000269|PubMed:38870534}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:30189608, ECO:0000269|PubMed:35547809}. Note=At interphase, forms a filamentous structure in the cytoplasm. During anaphase, translocates to the central spindle region and to the midbody during cytokinesis. Colocalized with SPAG4 at the nuclear periphery in round spermatids (By similarity). During sperm head formation in elongating spermatids, expressed at the acrosome, perinuclear mantle of the manchette structure and the sperm neck (PubMed:30189608, PubMed:35547809). Expressed at mitochondrial materials in elongating spermatids (PubMed:30189608). Expressed in mature sperm at the annulus, neck and tail (PubMed:25588830, PubMed:28346465, PubMed:38870534). Expressed at the midpiece in ejaculated mature sperm (PubMed:30189608). {ECO:0000250|UniProtKB:Q8IYM1, ECO:0000269|PubMed:25588830, ECO:0000269|PubMed:28346465, ECO:0000269|PubMed:30189608, ECO:0000269|PubMed:35547809, ECO:0000269|PubMed:38870534}.
uniprot
proteins