ACTR3
entrez
10096
canonical
uniprot
P61158
canonical
ensembl
ENSG00000115091
resolver
ensp
ENSP00000263238
resolver
ensp
ENSP00000444987
resolver
ensp
ENSP00000538128
resolver
ensp
ENSP00000538137
resolver
enst
ENST00000263238
resolver
enst
ENST00000535589
resolver
enst
ENST00000868069
resolver
enst
ENST00000868078
resolver
genesymbol
ACTR3
resolver
genesymbol_syn
ARP3
resolver
hgnc
HGNC:170
resolver
uniprot
B4DXW1
resolver
uniprot
F6SEZ6
resolver
uniprot
P32391
resolver
uniprot
Q53QM2
resolver
uniprot_entry
ARP3_HUMAN
resolver
uniprot_entry
B4DXW1_HUMAN
resolver
uniprot_entry
F6SEZ6_HUMAN
resolver
uniprot_sec
P32391
resolver
uniprot_sec
Q53QM2
resolver
amino_acid_sequence
MAGRLPACVVDCGTGYTKLGYAGNTEPQFIIPSCIAIKESAKVGDQAQRRVMKGVDDLDFFIGDEAIEKPTYATKWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGTVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIPPEQSLETAKAVKERYSYVCPDLVKEFNKYDTDGSKWIKQYTGINAISKKEFSIDVGYERFLGPEIFFHPEFANPDFTQPISEVVDEVIQNCPIDVRRPLYKNIVLSGGSTMFRDFGRRLQRDLKRTVDARLKLSEELSGGRLKPKPIDVQVITHHMQRYAVWFGGSMLASTPEFYQVCHTKKDYEEIGPSICRHNPVFGVMS
uniprot
proteins
function
FUNCTION: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9000076). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9000076). Seems to contact the pointed end of the daughter actin filament (PubMed:9000076). In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation (PubMed:29058690). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:17220302, PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). Plays a role in ciliogenesis (PubMed:20393563). {ECO:0000269|PubMed:17220302, ECO:0000269|PubMed:20393563, ECO:0000269|PubMed:29058690, ECO:0000269|PubMed:29925947, ECO:0000269|PubMed:9000076}.
uniprot
proteins
mass_dalton
47371
uniprot
proteins
protein_family
ARP3 subfamily
uniprot
proteins
protein_family
Actin family
uniprot
proteins
pubmed
11741539
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16767080
uniprot
proteins
pubmed
17220302
uniprot
proteins
pubmed
18614018
uniprot
proteins
pubmed
19109554
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20393563
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29058690
uniprot
proteins
pubmed
29925947
uniprot
proteins
pubmed
9000076
uniprot
proteins
pubmed
9230079
uniprot
proteins
sequence_length
418
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19109554}. Cell projection {ECO:0000269|PubMed:9230079}. Nucleus {ECO:0000269|PubMed:16767080, ECO:0000269|PubMed:17220302, ECO:0000269|PubMed:29925947}. Note=In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes) (PubMed:19109554).
uniprot
proteins