Nmu
entrez
56183
canonical
uniprot
Q9QXK8
canonical
ensembl
ENSMUSG00000029236
resolver
ensp
ENSMUSP00000031146
resolver
enst
ENSMUST00000031146
resolver
genesymbol
Nmu
resolver
uniprot
Q059S5
resolver
uniprot_entry
NMU_MOUSE
resolver
uniprot_sec
Q059S5
resolver
amino_acid_sequence
MSRAAGHRPGLSAGQLAAATASPLLSLLLLLACCADACKGVPISPQRLQPEQELQLWNEIHEACASFLSIDSRPQASVALRELCRIVMEISQKPQEQSEKDNTKRFLFHYSKTQKLGNSNVVSSVVHPLLQLVPQLHERRMKRFKAEYQSPSVGQSKGYFLFRPRNGKRSTSFI
uniprot
proteins
function
FUNCTION: [Neuromedin-U-23]: Multifunctional neuropeptide that acts via two G protein-coupled receptors, NMUR1 and NMUR2 (By similarity). Functionally, is involved in pleiotropic roles, including regulation of feeding, energy balance, blood pressure and smooth muscle contraction (By similarity). Additionally modulates hormone release and inflammatory responses in a tissue- and receptor-dependent manner (PubMed:33857254). Mechanistically, binding to NMUR1 or NMUR2 results in coupling of receptors to Galpha proteins, namely GNAQ/Gaq or GNA11/Ga11 and GNAI1/Gai subunits. GNAQ/Gaq or GNA11/Ga11 coupling leads to the activation of a phospholipase C (PLC), which hydrolyzes PIP2 (phosphatidylinositol 4,5-bisphosphate) into DAG (diacylglycerol) and IP3 (inositol trisphosphate), and subsequent intracellular calcium mobilization via IP3 receptors on the endoplasmic reticulum. GNAI1/Gai coupling inhibits forskolin-stimulated cAMP accumulation (By similarity). In pancreatic beta cells, regulates insulin secretion through NMUR1 coupled to GNAI2 and GNAO1, resulting in reduced intracellular Ca2+ influx and cAMP levels (PubMed:33857254). Through NMUR1 in Th2-type T cells, enhances type 2 cytokine secretion and modulates inflammatory responses via activation of PLC-calcineurin-MEK and PI3K signaling pathways (By similarity). {ECO:0000250|UniProtKB:P12760, ECO:0000250|UniProtKB:P34964, ECO:0000250|UniProtKB:P48645, ECO:0000269|PubMed:33857254}.; FUNCTION: [Neuromedin precursor-related peptide 33]: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release although its potency is much lower than that of neuromedin precursor-related peptide 36. {ECO:0000250|UniProtKB:P12760}.; FUNCTION: [Neuromedin precursor-related peptide 36]: Does not function as a ligand for either NMUR1 or NMUR2. Indirectly induces prolactin release from lactotroph cells in the pituitary gland, probably via the hypothalamic dopaminergic system. {ECO:0000250|UniProtKB:P12760}.
uniprot
proteins
mass_dalton
19429
uniprot
proteins
protein_family
NmU family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
28874765
uniprot
proteins
pubmed
33857254
uniprot
proteins
sequence_length
174
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Neuromedin-U-23]: Secreted {ECO:0000250|UniProtKB:P12760}.
uniprot
proteins