Q5U405
uniprot
Q5U405
canonical
activity_regulation
ACTIVITY REGULATION: Cleavage of HGF is inhibited by SPINT1/HAI-1 via the BPTI/Kunitz inhibitor 1 domain. {ECO:0000250|UniProtKB:Q9BYE2}.
uniprot
proteins
amino_acid_sequence
MDRGSHRNSSPARTPPQASPARTSPARAPPQASPARTPPQASPARTPPQASPARAPPPQASPARASPARAPPSRSSSGRSSSARSASTTSSPTRVYLVRATPVGAVPIRASPARSAPATRATRESPGLSFPKFSWQETQRQLPLIGCVILLISLVISLILLFYFWRGHTGIKYKEPLESCPIHAVRCDGVVDCKMKSDELGCVRFDWDKSLLKVYSGSSGEWLPVCSSSWNDTDSKRTCQQLGFDSAYRTTEVAHRDITSSFLLSEYNTTIQESLYRSQCSSRRYVSLQCSHCGLRAMTGRIVGGALTSESKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKLLEGWKVYAGTSNLHQLPEAASISQIIINGNYTDEQDDYDIALIRLSKPLTLSAHIHPACLPMHGQTFGLNETCWITGFGKTKETDEKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQKNKPGVYTKVTEVLPWIYRKMESEVRFRKS
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Serine protease (By similarity). Cleaves the proform of PRSS8/prostasin to form the active protein (By similarity). Cleaves the proform of HGF to form the active protein which promotes MAPK signaling (By similarity). Promotes the formation of the stratum corneum and subsequently the epidermal barrier in embryos (PubMed:24832573). {ECO:0000250|UniProtKB:Q9BYE2, ECO:0000269|PubMed:24832573}.
uniprot
proteins
mass_dalton
59806
uniprot
proteins
post_translational_modification
PTM: The inactive zymogen is post-translationally modified and then trafficked to the cell surface, whereby it undergoes autocatalytic cleavage resulting in an activated form that is released extracellularly. {ECO:0000250|UniProtKB:Q9BYE2}.; PTM: Phosphorylation is required for localization at the cell surface (By similarity). Phosphorylation increases following inhibition of protease activity by SPINT2/HAI-2 (By similarity). {ECO:0000250|UniProtKB:Q9BYE2}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24832573
uniprot
proteins
sequence_length
543
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9BYE2}; Single-pass type II membrane protein {ECO:0000255}. Secreted {ECO:0000250|UniProtKB:Q9BYE2}. Cytoplasm {ECO:0000250|UniProtKB:Q9BYE2}. Note=The non-phosphorylated, inactive full length protein localizes intracellularly (By similarity). N-glycosylation and phosphorylation is required for trafficking to the cell surface (By similarity). Interaction with SPINT1/HAI-1 and SPINT2/HAI-2 facilitate its translocation to the cell surface (By similarity). Proteolytic cleavage is required for secretion (By similarity). {ECO:0000250|UniProtKB:Q9BYE2}.
uniprot
proteins
transmembrane_region
TRANSMEM 144..164; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins