Slc9a2
entrez
24783
canonical
uniprot
P48763
canonical
ensembl
ENSRNOG00000015567
resolver
ensembl
ENSRNOG00055019822
resolver
ensembl
ENSRNOG00060019047
resolver
ensembl
ENSRNOG00065029915
resolver
ensp
ENSRNOP00000021270
resolver
ensp
ENSRNOP00000088725
resolver
genesymbol
Slc9a2
resolver
genesymbol_syn
Nhe2
resolver
uniprot
Q16434
resolver
uniprot_entry
SL9A2_RAT
resolver
uniprot_sec
Q16434
resolver
activity_regulation
ACTIVITY REGULATION: Li(+) activates Na(+)/H(+) exchanger. {ECO:0000269|PubMed:10678742}.
uniprot
proteins
amino_acid_sequence
MGPSGTAHRMRAPLSWLLLLLLSLQVAVPAGALAETLLDAPGARGASSNPPSPASVVAPGTTPFEESRLPVFTLDYPHVQIPFEITLWILLASLAKIGFHLYHKLPTIVPESCLLIMVGLLLGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTRPFFENLGTIFWYAVVGTLWNSIGIGLSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVFGESLLNDAVTVVLYNLFKSFCQMKTIQTVDVFAGIANFFVVGIGGVLIGILLGFIAAFTTRFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCLIWRALGVFVLTQVINWFRTIPLTFKDQFIIAYGGLRGAICFALVFLLPATVFPRKKLFITAAIVVIFFTVFILGITIRPLVEFLDVKRSNKKQQAVSEEIHCRFFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRKLLIRENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPSFASLNDCREEKIRKLTPGEMDEIREILSRNLYQIRQRTLSYNRHNLTADTSERQAKEILIRRRHSLRESLRKDNSLNRERRASTSTSRYLSLPKNTKLPEKLQKKNKVSNADGNSSDSDMDGTTVLNLQPRARRFLPDQFSKKASPAYKMEWKNEVDVGSARAPPSVTPAPRSKEGGTQTPGVLRQPLLSKDQRFGRGREDSLTEDVPPKPPPRLVRRASEPGNRKGRLGNEKP
uniprot
proteins
function
FUNCTION: Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) (PubMed:10678742, PubMed:8244988, PubMed:8244989). Major apical Na(+)/H(+) exchanger in the base of the colonic crypt. Controls in the colonic crypt intracellular pH (pHi) to direct colonic epithelial cell differentiation into the absorptive enterocyte lineage at the expense of the secretory lineage (By similarity). {ECO:0000250|UniProtKB:Q3ZAS0, ECO:0000269|PubMed:10678742, ECO:0000269|PubMed:8244988, ECO:0000269|PubMed:8244989}.
uniprot
proteins
mass_dalton
91403
uniprot
proteins
protein_family
Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
uniprot
proteins
pubmed
10678742
uniprot
proteins
pubmed
12576672
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7683411
uniprot
proteins
pubmed
7685026
uniprot
proteins
pubmed
8244988
uniprot
proteins
pubmed
8244989
uniprot
proteins
pubmed
8595899
uniprot
proteins
sequence_length
813
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q9UBY0}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the brush-border membrane throughout the intestinal tract. {ECO:0000269|PubMed:7685026}.
uniprot
proteins
transmembrane_region
TRANSMEM 108..128; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 139..159; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 170..190; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 210..230; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 238..258; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 279..299; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 309..329; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 362..382; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 393..413; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 431..451; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 460..480; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins