Atp6v0a1
entrez
11975
canonical
uniprot
Q9Z1G4
canonical
ensembl
ENSMUSG00000019302
resolver
ensp
ENSMUSP00000044838
resolver
ensp
ENSMUSP00000090333
resolver
ensp
ENSMUSP00000099399
resolver
ensp
ENSMUSP00000170952
resolver
ensp
ENSMUSP00000170953
resolver
ensp
ENSMUSP00000170954
resolver
ensp
ENSMUSP00000170955
resolver
ensp
ENSMUSP00000170956
resolver
ensp
ENSMUSP00000170961
resolver
ensp
ENSMUSP00000170964
resolver
ensp
ENSMUSP00000170967
resolver
ensp
ENSMUSP00000170974
resolver
ensp
ENSMUSP00000170978
resolver
ensp
ENSMUSP00000171013
resolver
ensp
ENSMUSP00000331177
resolver
genesymbol
Atp6v0a1
resolver
genesymbol_syn
Atp6n1
resolver
uniprot
A2A5A1
resolver
uniprot
Q3TXT5
resolver
uniprot
Q3TY98
resolver
uniprot
Q99M55
resolver
uniprot
Q9JHJ4
resolver
uniprot
Q9JL13
resolver
uniprot
Q9JL14
resolver
uniprot_entry
Q3TXT5_MOUSE
resolver
uniprot_entry
Q3TY98_MOUSE
resolver
uniprot_entry
Q99M55_MOUSE
resolver
uniprot_entry
VPP1_MOUSE
resolver
uniprot_sec
A2A5A1
resolver
uniprot_sec
Q9JHJ4
resolver
uniprot_sec
Q9JL13
resolver
uniprot_sec
Q9JL14
resolver
amino_acid_sequence
MGELFRSEEMTLAQLFLQSEAAYCCVSELGELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFEKIENELKEINTNQEALKRNFLELTELKFILRKTQQFFDEAELHHQQMADPDLLEESSSLLEPNEMGRGAPLRLGFVAGVINRERIPTFERMLWRVCRGNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKKICEGFRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAEVWCPVTDLDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTHGFQNIVDAYGIGTYREINPAPYTVITFPFLFAVMFGDFGHGILMTLFAVWMVLRESRILSQKHENEMFSMVFSGRYIILLMGLFSIYTGLIYNDCFSKSLNIFGSSWSVRPMFTQGNWTEETLLGSSVLQLNPAIPGVFGGPYPFGIDPIWNIATNKLTFLNSFKMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEIIFMSSLFGYLVILIFYKWTAYDAHSSRNAPSLLIHFINMFLFSYPESGNAMLYSGQKGIQCFLIVVAMLCVPWMLLFKPLILRHQYLRKKHLGTLNFGGIRVGNGPTEEDAEIIQHDQLSTHSEDAEEFDFGDTMVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHIGLHVRSLAGGLGLFFIFAAFATLTVAILLIMEGLSAFLHALRLHWVEFQNKFYTGTGFKFLPFSFEHIREGKFDE
uniprot
proteins
function
FUNCTION: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for the acidification of various organelles, such as lysosomes, endosomes, the trans-Golgi network, and secretory granules, including synaptic vesicles. In certain cell types, can be exported to the plasma membrane, where it is involved in the acidification of the extracellular environment (By similarity). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity). Required for assembly and activity of the vacuolar ATPase (By similarity). Through its action on compartment acidification, plays an essential role in neuronal development in terms of integrity and connectivity of neurons (PubMed:33833240). {ECO:0000250|UniProtKB:P32563, ECO:0000250|UniProtKB:Q29466, ECO:0000250|UniProtKB:Q93050, ECO:0000269|PubMed:33833240}.
uniprot
proteins
mass_dalton
96467
uniprot
proteins
protein_family
V-ATPase 116 kDa subunit family
uniprot
proteins
pubmed
10702241
uniprot
proteins
pubmed
10722719
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28024296
uniprot
proteins
pubmed
33833240
uniprot
proteins
sequence_length
839
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:P25286}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P25286}; Multi-pass membrane protein {ECO:0000255}. Melanosome {ECO:0000250|UniProtKB:Q93050}.
uniprot
proteins
transmembrane_region
TRANSMEM 396..414; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 417..433; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 449..478; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 543..562; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 581..601; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 647..666; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 727..751; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 773..811; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins