Cfd
entrez
54249
canonical
uniprot
P32038
canonical
ensembl
ENSRNOG00000033564
resolver
ensembl
ENSRNOG00055032763
resolver
ensembl
ENSRNOG00060023586
resolver
ensembl
ENSRNOG00065020165
resolver
ensp
ENSRNOP00000015029
resolver
ensp
ENSRNOP00055046748
resolver
ensp
ENSRNOP00060033804
resolver
ensp
ENSRNOP00065027243
resolver
enst
ENSRNOT00055056642
resolver
enst
ENSRNOT00060040866
resolver
enst
ENSRNOT00065034025
resolver
genesymbol
Cfd
resolver
genesymbol_syn
Adn
resolver
genesymbol_syn
Df
resolver
uniprot_entry
CFAD_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Circulates in plasma in a mature but self-inhibited form. Activated by factor B (CFB), which displaces the self-inhibition loop. Associates with CFB complexed with complement C3b. {ECO:0000250|UniProtKB:P00746}.
uniprot
proteins
amino_acid_sequence
MHSSVYLVALVVLEAAVCVAQPRGRILGGQEAMAHARPYMASVQVNGTHVCGGTLVDEQWVLSAAHCMDGVTKDEVVQVLLGAHSLSSPEPYKHLYDVQSVVLHPGSRPDSVEDDLMLFKLSHNASLGPHVRPLPLQREDREVKPGTLCDVAGWGVVTHAGRRPDVLQQLTVSIMDRNTCNLRTYHDGAITKNMMCAESNRRDTCRGDSGGPLVCGDAVEAVVTWGSRVCGNRRKPGVFTRVATYVPWIENVLSGNVSVNVTA
uniprot
proteins
ec_number
3.4.21.46
uniprot
proteins
function
FUNCTION: Serine protease that initiates the alternative pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. In contrast to other complement pathways (classical, lectin and GZMK) that are directly activated by pathogens or antigen-antibody complexes, the alternative complement pathway is initiated by the spontaneous hydrolysis of complement C3. The alternative complement pathway acts as an amplification loop that enhances complement activation by mediating the formation of C3 and C5 convertases. Activated CFD cleaves factor B (CFB) when the latter is complexed with complement C3b, activating the C3 convertase of the alternative pathway. {ECO:0000250|UniProtKB:P00746}.
uniprot
proteins
mass_dalton
28442
uniprot
proteins
post_translational_modification
PTM: CFD is activated by the removal of 5 residues at the N-terminus, named activation peptide, by the MASP-3 isoform of MASP1. {ECO:0000250|UniProtKB:P00746}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
1953671
uniprot
proteins
pubmed
8083356
uniprot
proteins
sequence_length
263
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1953671}.
uniprot
proteins