Gja8
entrez
14616
canonical
uniprot
P28236
canonical
ensembl
ENSMUSG00000049908
resolver
ensp
ENSMUSP00000049532
resolver
enst
ENSMUST00000062944
resolver
genesymbol
Gja8
resolver
uniprot
Q548M7
resolver
uniprot_entry
CXA8_MOUSE
resolver
uniprot_entry
Q548M7_MOUSE
resolver
amino_acid_sequence
MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPGCENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHHVRMEEKRKDREAEELCQQSRSNGGERVPIAPDQASIRKSSSSSKGTKKFRLEGTLLRTYVCHIIFKTLFEVGFIVGHYFLYGFRILPLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVAFVSLFLNIMEMSHLGMKGIRSAFKRPVEQPLGEIAEKSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMVETSPLSAKPFSQFEEKIGTGPLADMSRSYQETLPSYAQVGVQEVEREEPPIEEAVEPEVGEKKQEAEKVAPEGQETVAVPDRERVETPGVGKEDEKEELQAEKVTKQGLSAEKAPSLCPELTTDDNRPLSRLSKASSRARSDDLTI
uniprot
proteins
function
FUNCTION: Structural component of eye lens gap junctions (PubMed:1325220). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:1325220). {ECO:0000250|UniProtKB:P55917, ECO:0000269|PubMed:1325220}.
uniprot
proteins
mass_dalton
49598
uniprot
proteins
protein_family
Alpha-type (group II) subfamily
uniprot
proteins
protein_family
Connexin family
uniprot
proteins
pubmed
1325220
uniprot
proteins
sequence_length
440
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1325220}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55917}. Cell junction, gap junction {ECO:0000305|PubMed:1325220}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P55917"; TRANSMEM 72..92; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P55917"; TRANSMEM 162..182; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P55917"; TRANSMEM 211..231; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P55917
uniprot
proteins