TSPAN8
entrez
7103
canonical
uniprot
P19075
canonical
ensembl
ENSG00000127324
resolver
ensp
ENSP00000247829
resolver
ensp
ENSP00000377003
resolver
ensp
ENSP00000447160
resolver
ensp
ENSP00000531148
resolver
ensp
ENSP00000531149
resolver
ensp
ENSP00000531150
resolver
ensp
ENSP00000531152
resolver
ensp
ENSP00000531153
resolver
ensp
ENSP00000531156
resolver
ensp
ENSP00000531159
resolver
ensp
ENSP00000531161
resolver
ensp
ENSP00000633130
resolver
enst
ENST00000247829
resolver
enst
ENST00000393330
resolver
enst
ENST00000546561
resolver
enst
ENST00000861089
resolver
enst
ENST00000861090
resolver
enst
ENST00000861091
resolver
enst
ENST00000861093
resolver
enst
ENST00000861094
resolver
enst
ENST00000861097
resolver
enst
ENST00000861100
resolver
enst
ENST00000861102
resolver
enst
ENST00000963071
resolver
genesymbol
TSPAN8
resolver
genesymbol_syn
TM4SF3
resolver
hgnc
HGNC:11855
resolver
uniprot
B2R7T7
resolver
uniprot
Q9BS78
resolver
uniprot_entry
TSN8_HUMAN
resolver
uniprot_sec
B2R7T7
resolver
uniprot_sec
Q9BS78
resolver
amino_acid_sequence
MAGVSACIKYSMFTFNFLFWLCGILILALAIWVRVSNDSQAIFGSEDVGSSSYVAVDILIAVGAIIMILGFLGCCGAIKESRCMLLLFFIGLLLILLLQVATGILGAVFKSKSDRIVNETLYENTKLLSATGESEKQFQEAIIVFQEEFKCCGLVNGAADWGNNFQHYPELCACLDKQRPCQSYNGKQVYKETCISFIKDFLAKNLIIVIGISFGLAVIEILGLVFSMVLYCQIGNK
uniprot
proteins
function
FUNCTION: Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling (PubMed:27180357, PubMed:36078095). Participates thereby in diverse biological functions such as cell signal transduction, migration and protein trafficking (PubMed:25761241). Promotes ADAM17-mediated TNF processing through recruitment of ADAM17 to tetraspanin-enriched micro-domains (TEMs) (PubMed:36078095). Forms a complex with RICTOR and integrin alpha3/ITGA3 to mediate mTORC2 activation and AKT1 phosphorylation leading to cell migration (PubMed:25761241). Reduces apoptosis and autophagy induced by high glucose levels through forming a complex with mTOR and RICTOR (PubMed:35904232). Contributes to the maintenance of intestinal epithelial barrier and plays a role in the regulation of intestine inflammation by switching interferon gamma receptor 1/IFNGR1 from clathrin-dependent to lipid raft-dependent endocytosis route to limit STAT1 activation magnitude and duration (PubMed:37204469). Acts as a modulator of the endothelin axis by associating with endothelin converting enzyme ECE1 and regulating its activity of conversion of the endothelin-1 precursor to endothelin (PubMed:37835445). {ECO:0000269|PubMed:25761241, ECO:0000269|PubMed:27180357, ECO:0000269|PubMed:35904232, ECO:0000269|PubMed:36078095, ECO:0000269|PubMed:37204469, ECO:0000269|PubMed:37835445}.
uniprot
proteins
mass_dalton
26044
uniprot
proteins
mutagenesis
MUTAGEN 133; /note="E->A: No difference in TSPAN8-mediated MEP1B activity."; /evidence="ECO:0000269|PubMed:27180357"; MUTAGEN 135; /note="E->A: No difference in TSPAN8-mediated MEP1B activity."; /evidence="ECO:0000269|PubMed:27180357
uniprot
proteins
protein_family
Tetraspanin (TM4SF) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
2395876
uniprot
proteins
pubmed
25761241
uniprot
proteins
pubmed
27180357
uniprot
proteins
pubmed
34524408
uniprot
proteins
pubmed
35904232
uniprot
proteins
pubmed
36078095
uniprot
proteins
pubmed
37204469
uniprot
proteins
pubmed
37835445
uniprot
proteins
sequence_length
237
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27180357, ECO:0000269|PubMed:34524408, ECO:0000269|PubMed:37204469, ECO:0000269|PubMed:37835445}; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 10..33; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 58..72; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 84..109; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 206..230; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins