Clic4
entrez
83718
canonical
uniprot
Q9Z0W7
canonical
ensembl
ENSRNOG00000018109
resolver
ensp
ENSRNOP00000024464
resolver
enst
ENSRNOT00000024464
resolver
genesymbol
Clic4
resolver
uniprot
G3V8C4
resolver
uniprot_entry
CLIC4_RAT
resolver
uniprot_entry
G3V8C4_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Channel activity is redox- and pH-regulated. Anion vs cation selectivity is enhanced when fully oxidized. {ECO:0000269|PubMed:17453412}.
uniprot
proteins
amino_acid_sequence
MALSMPLNGLKEEDKEPLIELFVKAGSDGESIGNCPFSQRLFMILWLKGVVFSVTTVDLKRKPAHLQNLAPGTHPPFITFNSEVKTDVNKIEEFLEEVLCPPKYLKLSPKHPESNTAGMDIFAKFSAYIKNSRPEANEALERGLLKTLQKLDEYLNSPLPGEIDENSMEDIKSSTRRFLDGDEMTLADCNLLPKLHIVKVVAKKYRNFDIPKGMTGIWRYLTNAYSRDEFTNTCPSDKEVEIAYSDVAKRLTK
uniprot
proteins
ec_number
1.8.-.-
uniprot
proteins
function
FUNCTION: In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (By similarity). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions (PubMed:17453412, PubMed:9295337). Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Promotes cell-surface expression of HRH3. {ECO:0000250|UniProtKB:Q9Y696, ECO:0000269|PubMed:17453412, ECO:0000269|PubMed:18302930, ECO:0000269|PubMed:9295337}.
uniprot
proteins
mass_dalton
28633
uniprot
proteins
protein_family
Chloride channel CLIC family
uniprot
proteins
pubmed
17453412
uniprot
proteins
pubmed
18302930
uniprot
proteins
pubmed
26777142
uniprot
proteins
pubmed
9295337
uniprot
proteins
sequence_length
253
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9Y696}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9Y696}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9Y696}. Nucleus {ECO:0000250|UniProtKB:Q9Y696}. Cell membrane {ECO:0000250|UniProtKB:Q9Y696}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9Y696}. Mitochondrion {ECO:0000269|PubMed:26777142}. Cell junction {ECO:0000250|UniProtKB:Q9Y696}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:9295337}; Single-pass membrane protein {ECO:0000305|PubMed:17453412}. Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles. Might not be present in the nucleus of cardiac cells. {ECO:0000250|UniProtKB:Q9Y696, ECO:0000269|PubMed:26777142}.
uniprot
proteins
transmembrane_region
TRANSMEM 37..57; /note="Helical; Note=After insertion into the membrane"; /evidence="ECO:0000305|PubMed:17453412
uniprot
proteins