Calcr
entrez
116506
canonical
uniprot
P32214
canonical
ensembl
ENSRNOG00000010053
resolver
ensp
ENSRNOP00000013910
resolver
ensp
ENSRNOP00000013937
resolver
enst
ENSRNOT00000013910
resolver
enst
ENSRNOT00000013937
resolver
genesymbol
Calcr
resolver
uniprot
A0A0H2UHI1
resolver
uniprot
A0A0H2UHI3
resolver
uniprot
P32213
resolver
uniprot_entry
A0A0H2UHI1_RAT
resolver
uniprot_entry
A0A0H2UHI3_RAT
resolver
uniprot_entry
CALCR_RAT
resolver
uniprot_sec
P32213
resolver
amino_acid_sequence
MRFLLLNRFTLLLLLLVSPTPVLQAPTNLTDSGLDQEPFLYLVGRKKLLDAQYKCYDRIQQLPPYEGEGPYCNRTWDGWMCWDDTPAGVMSYQHCPDYFPDFDPTEKVSKYCDENGEWFRHPDSNRTWSNYTLCNAFTPDKLHNAYVLYYLALVGHSMSIAALIASMGIFLFFKNLSCQRVTLHKNMFLTYILNSIIIIIHLVEVVPNGDLVRRDPMHIFHHNTYMWTMQWELSPPLPLSAHEGKMDPHDSEVISCKILHFFHQYMMACNYFWMLCEGIYLHTLIVMAVFTEDQRLRWYYLLGWGFPIVPTIIHAITRAVYYNDNCWLSTETHLLYIIHGPVMAALVVNFFFLLNIVRVLVTKMRQTHEAEAYMYLKAVKATMVLVPLLGIQFVVFPWRPSNKVLGKIYDYLMHSLIHFQGFFVATIYCFCNHEVQVTLKRQWAQFKIQWSHRWGRRRRPTNRVVSAPRAVAFAEPGGLPIYICHQEPRNPPVSNNEGEEGTEMIPMNVIQQDSSA
uniprot
proteins
function
FUNCTION: G protein-coupled receptor activated by ligand peptides amylin (IAPP), calcitonin (CT/CALCA) and calcitonin gene-related peptide type 1 (CGRP1/CALCA). CALCR interacts with receptor-activity-modifying proteins RAMP1, 2 and 3 to form receptor complexes AMYR1, 2 and 3, respectively. IAPP, CT and CGRP1 activate CALCR and AMYRs with distinct modes of receptor activation resulting in specific phenotypes. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. {ECO:0000250|UniProtKB:P30988}.
uniprot
proteins
mass_dalton
60292
uniprot
proteins
protein_family
G protein-coupled receptor 2 family
uniprot
proteins
pubmed
8391477
uniprot
proteins
pubmed
8395656
uniprot
proteins
sequence_length
516
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P30988}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P30988}.
uniprot
proteins
transmembrane_region
TRANSMEM 147..169; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P30988"; TRANSMEM 182..202; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P30988"; TRANSMEM 257..279; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P30988"; TRANSMEM 297..317; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P30988"; TRANSMEM 334..357; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P30988"; TRANSMEM 378..396; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P30988"; TRANSMEM 405..431; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P30988
uniprot
proteins