RAB4A
entrez
5867
canonical
uniprot
P20338
canonical
ensembl
ENSG00000168118
resolver
ensp
ENSP00000355651
resolver
ensp
ENSP00000482077
resolver
ensp
ENSP00000565534
resolver
ensp
ENSP00000565535
resolver
ensp
ENSP00000589145
resolver
enst
ENST00000366690
resolver
enst
ENST00000618010
resolver
enst
ENST00000895475
resolver
enst
ENST00000895476
resolver
enst
ENST00000919086
resolver
genesymbol
RAB4A
resolver
genesymbol_syn
RAB4
resolver
hgnc
HGNC:9781
resolver
uniprot
A0A087WYT5
resolver
uniprot
Q5T7P7
resolver
uniprot
Q9BQ44
resolver
uniprot_entry
A0A087WYT5_HUMAN
resolver
uniprot_entry
RAB4A_HUMAN
resolver
uniprot_sec
Q5T7P7
resolver
uniprot_sec
Q9BQ44
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MSQTAMSETYDFLFKFLVIGNAGTGKSCLLHQFIEKKFKDDSNHTIGVEFGSKIINVGGKYVKLQIWDTAGQERFRSVTRSYYRGAAGALLVYDITSRETYNALTNWLTDARMLASQNIVIILCGNKKDLDADREVTFLEASRFAQENELMFLETSALTGENVEEAFVQCARKILNKIESGELDPERMGSGIQYGDAALRQLRSPRRAQAPNAQECGC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:15907487, PubMed:16034420). RAB4A is involved in protein transport (PubMed:29425100). Also plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling (PubMed:29425100). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity). {ECO:0000250|UniProtKB:P56371, ECO:0000269|PubMed:15907487, ECO:0000269|PubMed:16034420, ECO:0000269|PubMed:29425100}.
uniprot
proteins
mass_dalton
24390
uniprot
proteins
mutagenesis
MUTAGEN 51; /note="G->A: 10-fold decrease in ZFYVE20 binding affinity."; /evidence="ECO:0000269|PubMed:16034420"; MUTAGEN 51; /note="G->L: 10-fold decrease in ZFYVE20 binding affinity."; /evidence="ECO:0000269|PubMed:16034420
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CDK1 kinase during mitosis. {ECO:0000269|PubMed:1425574, ECO:0000269|PubMed:1902553}.; PTM: Serotonylation of Gln-72 by TGM2 during activation and aggregation of platelets leads to constitutive activation of GTPase activity. {ECO:0000250|UniProtKB:P56371}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10698684
uniprot
proteins
pubmed
11786538
uniprot
proteins
pubmed
11788822
uniprot
proteins
pubmed
1425574
uniprot
proteins
pubmed
14617813
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15280022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15907487
uniprot
proteins
pubmed
16034420
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16935861
uniprot
proteins
pubmed
17786215
uniprot
proteins
pubmed
1902553
uniprot
proteins
pubmed
20098723
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2501306
uniprot
proteins
pubmed
29425100
uniprot
proteins
sequence_length
218
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein {ECO:0000269|PubMed:1425574}. Cytoplasm {ECO:0000269|PubMed:1425574}. Early endosome membrane {ECO:0000250|UniProtKB:P05714}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05714}. Recycling endosome membrane {ECO:0000250|UniProtKB:P05714}; Peripheral membrane protein {ECO:0000250|UniProtKB:P05714}. Note=Generally associated with membranes. Cytoplasmic when phosphorylated by CDK1. {ECO:0000269|PubMed:1425574}.
uniprot
proteins