IL36G
entrez
56300
canonical
uniprot
Q9NZH8
canonical
ensembl
ENSG00000136688
resolver
ensp
ENSP00000259205
resolver
ensp
ENSP00000365672
resolver
genesymbol
IL36G
resolver
genesymbol_syn
IL1E
resolver
genesymbol_syn
IL1F9
resolver
genesymbol_syn
IL1H1
resolver
genesymbol_syn
IL1RP2
resolver
hgnc
HGNC:15741
resolver
uniprot
Q56B91
resolver
uniprot
Q6UVX7
resolver
uniprot
Q7RTZ9
resolver
uniprot_entry
IL36G_HUMAN
resolver
uniprot_sec
Q56B91
resolver
uniprot_sec
Q6UVX7
resolver
uniprot_sec
Q7RTZ9
resolver
amino_acid_sequence
MRGTPGDADGGGRAVYQSMCKPITGTINDLNQQVWTLQGQNLVAVPRSDSVTPVTVAVITCKYPEALEQGRGDPIYLGIQNPEMCLYCEKVGEQPTLQLKEQKIMDLYGQPEPVKPFLFYRAKTGRTSTLESVAFPDWFIASSKRDQPIILTSELGKSYNTAFELNIND
uniprot
proteins
function
FUNCTION: Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1; also stimulates its own expression and that of the prototypic cutaneous pro-inflammatory parameters TNF, S100A7/psoriasin and inducible NOS. May play a role in pro-inflammatory responses during particular neutrophilic airway inflammation: activates mitogen-activated protein kinases and NF-kappa B in primary lung fibroblasts, and stimulates the expression of IL-8 and CXCL3 and Th17 chemokine CCL20 in lung fibroblasts. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. {ECO:0000269|PubMed:11466363, ECO:0000269|PubMed:20870894, ECO:0000269|PubMed:21965679, ECO:0000269|PubMed:23095752, ECO:0000269|PubMed:23147407, ECO:0000269|PubMed:24829417}.
uniprot
proteins
mass_dalton
18721
uniprot
proteins
post_translational_modification
PTM: N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold) (PubMed:21965679). Proteolytically cleaved by cathepsin CTSG (PubMed:30804664). {ECO:0000269|PubMed:21965679, ECO:0000269|PubMed:30804664}.
uniprot
proteins
protein_family
IL-1 family
uniprot
proteins
pubmed
10744718
uniprot
proteins
pubmed
10860666
uniprot
proteins
pubmed
11466363
uniprot
proteins
pubmed
11991722
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
20870894
uniprot
proteins
pubmed
21965679
uniprot
proteins
pubmed
23095752
uniprot
proteins
pubmed
23147407
uniprot
proteins
pubmed
24829417
uniprot
proteins
pubmed
30804664
uniprot
proteins
pubmed
32272059
uniprot
proteins
sequence_length
169
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:32272059}. Secreted {ECO:0000269|PubMed:20870894}. Note=The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. {ECO:0000269|PubMed:32272059}.
uniprot
proteins