Acot1
entrez
26897
canonical
uniprot
O55137
canonical
ensembl
ENSMUSG00000072949
resolver
ensp
ENSMUSP00000126448
resolver
enst
ENSMUST00000168120
resolver
genesymbol
Acot1
resolver
genesymbol_syn
Cte1
resolver
uniprot
Q549A9
resolver
uniprot_entry
ACOT1_MOUSE
resolver
uniprot_sec
Q549A9
resolver
amino_acid_sequence
MEATLNLEPSGRSCWDEPLSIAVRGLAPEQPVTLRSVLRDEKGALFRAHARYRADSHGELDLARTPALGGSFSGLEPMGLLWAMEPDRPFWRLVKRDVQTPFVVELEVLDGHEPDGGQRLAHAVHERHFLAPGVRRVPVREGRVRATLFLPPEPGPFPGIIDLFGVGGGLLEYRASLLAGKGFAVMALAYYNYDDLPKNMETMHMEYFEEAVNYLRSHPEVKGPGIGLLGISKGGELGLAMASFLKGITAAVVINGSVAAVGNTISYKDETIPPVTILRNQVKMTKDGLKDVVDALQSPLVDKKSFIPVERSDTTFLFLVGQDDHNWKSEFYADEISKRLQAHGKEKPQIICYPAAGHYIEPPYFPLCSAGMHLLVGANITFGGEPKPHAMAQLDAWQQLQTFFHKQLGSECLHVSPKI
uniprot
proteins
ec_number
3.1.2.-
uniprot
proteins
ec_number
3.1.2.2
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels. More active towards saturated and unsaturated long chain fatty acyl-CoAs (C12-C20). {ECO:0000269|PubMed:11694534}.
uniprot
proteins
mass_dalton
46136
uniprot
proteins
mutagenesis
MUTAGEN 232; /note="S->A: Abolishes activity."; /evidence="ECO:0000269|PubMed:11694534"; MUTAGEN 232; /note="S->C: Retains 2% of the initial activity; deacylation of the acyl-enzyme intermediate becomes rate-limiting."; /evidence="ECO:0000269|PubMed:11694534"; MUTAGEN 324; /note="D->A: Abolishes activity."; /evidence="ECO:0000269|PubMed:11694534"; MUTAGEN 358; /note="H->Q: Abolishes activity."; /evidence="ECO:0000269|PubMed:11694534
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid metabolism. {ECO:0000305|PubMed:11694534}.
uniprot
proteins
protein_family
C/M/P thioester hydrolase family
uniprot
proteins
pubmed
10567408
uniprot
proteins
pubmed
11330065
uniprot
proteins
pubmed
11694534
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9490035
uniprot
proteins
sequence_length
419
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O88267}.
uniprot
proteins