Actl7a
entrez
11470
canonical
uniprot
Q9QY84
canonical
ensembl
ENSMUSG00000070979
resolver
ensp
ENSMUSP00000092692
resolver
enst
ENSMUST00000095079
resolver
genesymbol
Actl7a
resolver
genesymbol_syn
Tact2
resolver
uniprot
A2AMK4
resolver
uniprot
Q9D9P4
resolver
uniprot
Q9JMI5
resolver
uniprot_entry
ACL7A_MOUSE
resolver
uniprot_sec
A2AMK4
resolver
uniprot_sec
Q9D9P4
resolver
uniprot_sec
Q9JMI5
resolver
amino_acid_sequence
MSLDGVWAPQTANIGDGPAKKASDQASMQTQVLQTASLKDGPAKRAVWVRRDNAETEDPVKSTMSKDRPRLEVTKAVVVDLGTGFCKCGFAGLPKPTHKISTTVGKPYMETAKTGDNRKETFVGHELFNPDIHLKLVNPLRHGIIVDWDTVQDIWEYLFRQEMKIAPEEHAVLVSDPPLSPHTNREKYAEMLFETFNTPAMHIAYQSRLSMYSYGRTSGLVVEVGHGVSYVVPIYEGYPLPSITGRLDYAGSDLTTYLMNLMNNSGKHFSEDHLGIVEDIKTRCCFVALDPIEEKKIPAPEHEIHYTLPDGKEIRLGQERFLCSEMFFKPSLIKSMQLGLHTQTVSCLNKCDIALKRDLMGNILLCGGSTMLRGFPNRLQKELSSMCPNDTPQVNVLPERDTAVWTGGSILASLQGFQPLWVHRLEYEEHGPFFLYRRCF
uniprot
proteins
function
FUNCTION: Essential for normal spermatogenesis and male fertility (PubMed:35921706, PubMed:36734600, PubMed:37667331). Required for normal sperm head morphology, acroplaxome formation, acrosome attachment, and acrosome granule stability (PubMed:36734600, PubMed:37667331). May anchor and stabilize acrosomal adherence to the acroplaxome at least in part by facilitating the presence of F-actin in the subacrosomal space (PubMed:36734600). May play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis (PubMed:32923619). {ECO:0000269|PubMed:32923619, ECO:0000269|PubMed:35921706, ECO:0000269|PubMed:36734600, ECO:0000269|PubMed:37667331}.
uniprot
proteins
mass_dalton
49451
uniprot
proteins
mutagenesis
MUTAGEN 250; /note="A->T: Homozygous knockin male mice are infertile. The spermatogenesis process is normal. However spermatozoa dysplay acrosomal ultrastructural defects. Complete absence of the ACTL7A protein in both testes and sperms. Abnormal distribution of PLCZ1 in sperms."; /evidence="ECO:0000269|PubMed:32923619
uniprot
proteins
protein_family
Actin family
uniprot
proteins
pubmed
10373328
uniprot
proteins
pubmed
12672658
uniprot
proteins
pubmed
12704725
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21278383
uniprot
proteins
pubmed
32923619
uniprot
proteins
pubmed
35921706
uniprot
proteins
pubmed
36734600
uniprot
proteins
pubmed
37667331
uniprot
proteins
pubmed
38573307
uniprot
proteins
sequence_length
440
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21278383}. Golgi apparatus {ECO:0000269|PubMed:21278383}. Cytoplasm {ECO:0000269|PubMed:12672658, ECO:0000269|PubMed:36734600}. Nucleus {ECO:0000269|PubMed:12672658, ECO:0000269|PubMed:21278383, ECO:0000269|PubMed:36734600}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:21278383}. Note=Detected at the Golgi apparatus during acrosome biogenesis (PubMed:21278383). Detected at the subacrosomal layer in round spermatids (PubMed:21278383). Detected in sperm head and tail (PubMed:21278383).
uniprot
proteins