CYP2A13
entrez
1553
canonical
uniprot
Q16696
canonical
ensembl
ENSG00000197838
resolver
ensp
ENSP00000332679
resolver
enst
ENST00000330436
resolver
genesymbol
CYP2A13
resolver
hgnc
HGNC:2608
resolver
uniprot
Q53YR8
resolver
uniprot
Q6R569
resolver
uniprot
Q6R570
resolver
uniprot
Q9H2X2
resolver
uniprot_entry
CP2AD_HUMAN
resolver
uniprot_sec
Q53YR8
resolver
uniprot_sec
Q6R569
resolver
uniprot_sec
Q6R570
resolver
uniprot_sec
Q9H2X2
resolver
amino_acid_sequence
MLASGLLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRNYTMSFLPR
uniprot
proteins
ec_number
1.14.14.1
uniprot
proteins
function
FUNCTION: Exhibits a coumarin 7-hydroxylase activity. Active in the metabolic activation of hexamethylphosphoramide, N,N-dimethylaniline, 2'-methoxyacetophenone, N-nitrosomethylphenylamine, and the tobacco-specific carcinogen, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Possesses phenacetin O-deethylation activity. {ECO:0000269|PubMed:18779312}.
uniprot
proteins
mass_dalton
56688
uniprot
proteins
mutagenesis
MUTAGEN 110; /note="L->V: Decreases phenacetin O-deethylation activity 8 fold."; /evidence="ECO:0000269|PubMed:18779312"; MUTAGEN 117; /note="A->V: Increases phenacetin O-deethylation activity 5 fold."; /evidence="ECO:0000269|PubMed:18779312"; MUTAGEN 208; /note="S->I: Decreases phenacetin O-deethylation activity 10 fold."; /evidence="ECO:0000269|PubMed:18779312"; MUTAGEN 213; /note="A->S: Decreases phenacetin O-deethylation activity 2 fold."; /evidence="ECO:0000269|PubMed:18779312"; MUTAGEN 300; /note="F->I: Decreases phenacetin O-deethylation activity 40 fold."; /evidence="ECO:0000269|PubMed:18779312"; MUTAGEN 301; /note="A->G: Decreases phenacetin O-deethylation activity 20 fold."; /evidence="ECO:0000269|PubMed:18779312"; MUTAGEN 365; /note="M->V: Decreases phenacetin O-deethylation activity 7 fold."; /evidence="ECO:0000269|PubMed:18779312"; MUTAGEN 366; /note="L->I: Increases phenacetin O-deethylation activity 3 fold."; /evidence="ECO:0000269|PubMed:18779312"; MUTAGEN 369; /note="G->S: Decreases phenacetin O-deethylation activity 9 fold."; /evidence="ECO:0000269|PubMed:18779312"; MUTAGEN 372; /note="H->R: Decreases phenacetin O-deethylation activity 3 fold."; /evidence="ECO:0000269|PubMed:18779312
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
11016631
uniprot
proteins
pubmed
12130698
uniprot
proteins
pubmed
12721789
uniprot
proteins
pubmed
15063809
uniprot
proteins
pubmed
15618722
uniprot
proteins
pubmed
17428784
uniprot
proteins
pubmed
17540336
uniprot
proteins
pubmed
18779312
uniprot
proteins
pubmed
7668294
uniprot
proteins
sequence_length
494
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
uniprot
proteins