DKK4
entrez
27121
canonical
uniprot
Q9UBT3
canonical
ensembl
ENSG00000104371
resolver
ensp
ENSP00000220812
resolver
ensp
ENSP00000787489
resolver
enst
ENST00000220812
resolver
genesymbol
DKK4
resolver
hgnc
HGNC:2894
resolver
uniprot
Q3KNX0
resolver
uniprot
Q9Y4C3
resolver
uniprot_entry
DKK4_HUMAN
resolver
uniprot_sec
Q3KNX0
resolver
uniprot_sec
Q9Y4C3
resolver
amino_acid_sequence
MVAAVLLGLSWLCSPLGALVLDFNNIRSSADLHGARKGSQCLSDTDCNTRKFCLQPRDEKPFCATCRGLRRRCQRDAMCCPGTLCVNDVCTTMEDATPILERQLDEQDGTHAEGTTGHPVQENQPKRKPSIKKSQGRKGQEGESCLRTFDCGPGLCCARHFWTKICKPVLLEGQVCSRRGHKDTAQAPEIFQRCDCGPGLLCRSQLTSNRQHARLRVCQKIEKL
uniprot
proteins
function
FUNCTION: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
24876
uniprot
proteins
post_translational_modification
PTM: Appears to be not glycosylated.; PTM: Can be proteolytically processed by a furin-like protease. {ECO:0000269|PubMed:10570958}.
uniprot
proteins
protein_family
Dickkopf family
uniprot
proteins
pubmed
10570958
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17143291
uniprot
proteins
sequence_length
224
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins