Cyp1a1
entrez
24296
canonical
uniprot
P00185
canonical
ensembl
ENSRNOG00000019500
resolver
ensembl
ENSRNOG00055029892
resolver
ensembl
ENSRNOG00060021246
resolver
ensembl
ENSRNOG00065017500
resolver
ensp
ENSRNOP00000026473
resolver
ensp
ENSRNOP00055042736
resolver
ensp
ENSRNOP00060030361
resolver
ensp
ENSRNOP00065023214
resolver
enst
ENSRNOT00000026473
resolver
enst
ENSRNOT00055051799
resolver
enst
ENSRNOT00060036849
resolver
enst
ENSRNOT00065029266
resolver
genesymbol
Cyp1a1
resolver
genesymbol_syn
Cyp1a-1
resolver
uniprot_entry
CP1A1_RAT
resolver
amino_acid_sequence
MPSVYGFPAFTSATELLLAVTTFCLGFWVVRVTRTWVPKGLKSPPGPWGLPFIGHVLTLGKNPHLSLTKLSQQYGDVLQIRIGSTPVVVLSGLNTIKQALVKQGDDFKGRPDLYSFTLIANGQSMTFNPDSGPLWAARRRLAQNALKSFSIASDPTLASSCYLEEHVSKEAEYLISKFQKLMAEVGHFDPFKYLVVSVANVICAICFGRRYDHDDQELLSIVNLSNEFGEVTGSGYPADFIPILRYLPNSSLDAFKDLNKKFYSFMKKLIKEHYRTFEKGHIRDITDSLIEHCQDRRLDENANVQLSDDKVITIVFDLFGAGFDTITTAISWSLMYLVTNPRIQRKIQEELDTVIGRDRQPRLSDRPQLPYLEAFILETFRHSSFVPFTIPHSTIRDTSLNGFYIPKGHCVFVNQWQVNHDQELWGDPNEFRPERFLTSSGTLDKHLSEKVILFGLGKRKCIGETIGRLEVFLFLAILLQQMEFNVSPGEKVDMTPAYGLTLKHARCEHFQVQMRSSGPQHLQA
uniprot
proteins
ec_number
1.14.14.1
uniprot
proteins
ec_number
4.2.1.152
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2, as well as D-ring hydroxylated E1 and E2 at the C15alpha and C16alpha positions (By similarity). Displays different regioselectivities for polyunsaturated fatty acids (PUFA) hydroxylation (By similarity). Catalyzes the epoxidation of double bonds of certain PUFA (PubMed:20972997). Converts arachidonic acid toward epoxyeicosatrienoic acid (EET) regioisomers, 8,9-, 11,12-, and 14,15-EET, that function as lipid mediators in the vascular system. Displays an absolute stereoselectivity in the epoxidation of eicosapentaenoic acid (EPA) producing the 17(R),18(S) enantiomer (By similarity). May play an important role in all-trans retinoic acid biosynthesis in extrahepatic tissues. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (By similarity). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (By similarity). {ECO:0000250|UniProtKB:P04798, ECO:0000269|PubMed:20972997}.
uniprot
proteins
mass_dalton
59393
uniprot
proteins
mutagenesis
MUTAGEN 32..33; /note="VT->AI: No proteolytic cleavage."; /evidence="ECO:0000269|PubMed:9348277
uniprot
proteins
pathway_participation
PATHWAY: Steroid hormone biosynthesis. {ECO:0000250|UniProtKB:P04798}.; PATHWAY: Lipid metabolism; fatty acid metabolism. {ECO:0000269|PubMed:20972997}.; PATHWAY: Cofactor metabolism; retinol metabolism. {ECO:0000250|UniProtKB:P04798}.
uniprot
proteins
post_translational_modification
PTM: Two forms; MT2A (long form) and MT2B (short form); are produced by NH2-terminal proteolytic cleavage. This cleavage activates a cryptic mitochondrial targeting signal.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
19401463
uniprot
proteins
pubmed
20972997
uniprot
proteins
pubmed
24098488
uniprot
proteins
pubmed
3041969
uniprot
proteins
pubmed
3718958
uniprot
proteins
pubmed
3838427
uniprot
proteins
pubmed
6089174
uniprot
proteins
pubmed
6324135
uniprot
proteins
pubmed
8651689
uniprot
proteins
pubmed
9348277
uniprot
proteins
sequence_length
524
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Cytochrome P450 1A1]: Cytoplasm {ECO:0000269|PubMed:9348277}.; SUBCELLULAR LOCATION: [Cytochrome P450MT2A]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:9348277}; Peripheral membrane protein {ECO:0000305|PubMed:19401463, ECO:0000305|PubMed:9348277}. Mitochondrion inner membrane {ECO:0000269|PubMed:9348277}; Peripheral membrane protein {ECO:0000305|PubMed:19401463, ECO:0000305|PubMed:9348277}. Microsome membrane {ECO:0000269|PubMed:9348277}; Peripheral membrane protein {ECO:0000305|PubMed:19401463, ECO:0000305|PubMed:9348277}.; SUBCELLULAR LOCATION: [Cytochrome P450MT2B]: Endoplasmic reticulum membrane; Peripheral membrane protein. Mitochondrion inner membrane {ECO:0000305|PubMed:19401463}; Peripheral membrane protein {ECO:0000305|PubMed:19401463, ECO:0000305|PubMed:9348277}. Microsome membrane {ECO:0000269|PubMed:9348277}; Peripheral membrane protein {ECO:0000305|PubMed:19401463, ECO:0000305|PubMed:9348277}.
uniprot
proteins