ATP6V1H
entrez
51606
canonical
uniprot
Q9UI12
canonical
ensembl
ENSG00000047249
resolver
ensp
ENSP00000347359
resolver
ensp
ENSP00000352522
resolver
ensp
ENSP00000379995
resolver
ensp
ENSP00000554492
resolver
genesymbol
ATP6V1H
resolver
hgnc
HGNC:18303
resolver
uniprot
B3KMR0
resolver
uniprot
B3KUZ7
resolver
uniprot
Q6PK44
resolver
uniprot
Q9H3E3
resolver
uniprot
Q9Y300
resolver
uniprot_entry
B3KUZ7_HUMAN
resolver
uniprot_entry
VATH_HUMAN
resolver
uniprot_sec
B3KMR0
resolver
uniprot_sec
Q6PK44
resolver
uniprot_sec
Q9H3E3
resolver
uniprot_sec
Q9Y300
resolver
amino_acid_sequence
MTKMDIRGAVDAAVPTNIIAAKAAEVRANKVNWQSYLQGQMISAEDCEFIQRFEMKRSPEEKQEMLQTEGSQCAKTFINLMTHICKEQTVQYILTMVDDMLQENHQRVSIFFDYARCSKNTAWPYFLPMLNRQDPFTVHMAARIIAKLAAWGKELMEGSDLNYYFNWIKTQLSSQKLRGSGVAVETGTVSSSDSSQYVQCVAGCLQLMLRVNEYRFAWVEADGVNCIMGVLSNKCGFQLQYQMIFSIWLLAFSPQMCEHLRRYNIIPVLSDILQESVKEKVTRIILAAFRNFLEKSTERETRQEYALAMIQCKVLKQLENLEQQKYDDEDISEDIKFLLEKLGESVQDLSSFDEYSSELKSGRLEWSPVHKSEKFWRENAVRLNEKNYELLKILTKLLEVSDDPQVLAVAAHDVGEYVRHYPRGKRVIEQLGGKQLVMNHMHHEDQQVRYNALLAVQKLMVHNWEYLGKQLQSEQPQTAAARS
uniprot
proteins
function
FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (By similarity). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (PubMed:22053050). Subunit H is essential for V-ATPase activity, but not for the assembly of the complex (By similarity). Involved in the endocytosis mediated by clathrin-coated pits, required for the formation of endosomes (PubMed:12032142). {ECO:0000250|UniProtKB:O46563, ECO:0000250|UniProtKB:P41807, ECO:0000269|PubMed:12032142, ECO:0000269|PubMed:22053050, ECO:0000269|PubMed:33065002}.
uniprot
proteins
mass_dalton
55883
uniprot
proteins
protein_family
V-ATPase H subunit family
uniprot
proteins
pubmed
10810093
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
12032142
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22053050
uniprot
proteins
pubmed
22087003
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25659576
uniprot
proteins
pubmed
33065002
uniprot
proteins
pubmed
9620685
uniprot
proteins
sequence_length
483
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:O46563}; Peripheral membrane protein {ECO:0000305}.
uniprot
proteins