PLA2G4B
entrez
100137049
canonical
uniprot
P0C869
canonical
ensembl
ENSG00000168970
resolver
ensembl
ENSG00000243708
resolver
ensp
ENSP00000416610
resolver
genesymbol
PLA2G4B
resolver
hgnc
HGNC:9036
resolver
uniprot
B4DRT9
resolver
uniprot
O95712
resolver
uniprot
Q19KD5
resolver
uniprot
Q19KD6
resolver
uniprot
Q59GF9
resolver
uniprot
Q8TB10
resolver
uniprot
Q9UKV7
resolver
uniprot_entry
PA24B_HUMAN
resolver
uniprot_sec
B4DRT9
resolver
uniprot_sec
O95712
resolver
uniprot_sec
Q19KD5
resolver
uniprot_sec
Q19KD6
resolver
uniprot_sec
Q59GF9
resolver
uniprot_sec
Q8TB10
resolver
uniprot_sec
Q9UKV7
resolver
activity_regulation
ACTIVITY REGULATION: [Isoform 5]: Stimulated by cytosolic Ca(2+). {ECO:0000269|PubMed:10085124, ECO:0000269|PubMed:10358058}.
uniprot
proteins
amino_acid_sequence
MAVAEVSRTCLLTVRVLQAHRLPSKDLVTPSDCYVTLWLPTACSHRLQTRTVKNSSSPVWNQSFHFRIHRQLKNVMELKVFDQDLVTGDDPVLSVLFDAGTLRAGEFRRESFSLSPQGEGRLEVEFRLQSLADRGEWLVSNGVLVARELSCLHVQLEETGDQKSSEHRVQLVVPGSCEGPQEASVGTGTFRFHCPACWEQELSIRLQDAPEEQLKAPLSALPSGQVVRLVFPTSQEPLMRVELKKEAGLRELAVRLGFGPCAEEQAFLSRRKQVVAAALRQALQLDGDLQEDEIPVVAIMATGGGIRAMTSLYGQLAGLKELGLLDCVSYITGASGSTWALANLYEDPEWSQKDLAGPTELLKTQVTKNKLGVLAPSQLQRYRQELAERARLGYPSCFTNLWALINEALLHDEPHDHKLSDQREALSHGQNPLPIYCALNTKGQSLTTFEFGEWCEFSPYEVGFPKYGAFIPSELFGSEFFMGQLMKRLPESRICFLEGIWSNLYAANLQDSLYWASEPSQFWDRWVRNQANLDKEQVPLLKIEEPPSTAGRIAEFFTDLLTWRPLAQATHNFLRGLHFHKDYFQHPHFSTWKATTLDGLPNQLTPSEPHLCLLDVGYLINTSCLPLLQPTRDVDLILSLDYNLHGAFQQLQLLGRFCQEQGIPFPPISPSPEEQLQPRECHTFSDPTCPGAPAVLHFPLVSDSFREYSAPGVRRTPEEAAAGEVNLSSSDSPYHYTKVTYSQEDVDKLLHLTHYNVCNNQEQLLEALRQAVQRRRQRRPH
uniprot
proteins
ec_number
3.1.1.4
uniprot
proteins
ec_number
3.1.1.5
uniprot
proteins
function
FUNCTION: Calcium-dependent phospholipase A1 and A2 and lysophospholipase that may play a role in membrane phospholipid remodeling. {ECO:0000269|PubMed:10085124, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:16617059}.; FUNCTION: [Isoform 3]: Calcium-dependent phospholipase A2 and lysophospholipase. Cleaves the ester bond of the fatty acyl group attached to the sn-2 position of phosphatidylethanolamines, producing lysophospholipids that may be used in deacylation-reacylation cycles. Hydrolyzes lysophosphatidylcholines with low efficiency but is inefficient toward phosphatidylcholines. {ECO:0000269|PubMed:16617059}.; FUNCTION: [Isoform 5]: Calcium-dependent phospholipase A1 and A2 and lysophospholipase. Cleaves the ester bond of the fatty acyl group attached to the sn-1 or sn-2 position of diacyl phospholipids (phospholipase A1 and A2 activity, respectively), producing lysophospholipids that may be used in deacylation-reacylation cycles. Can further hydrolyze lysophospholipids enabling complete deacylation. Has no activity toward alkylacyl phospholipids. {ECO:0000269|PubMed:10085124, ECO:0000269|PubMed:10358058, ECO:0000269|PubMed:16617059}.
uniprot
proteins
mass_dalton
87978
uniprot
proteins
mutagenesis
MUTAGEN 335; /note="S->A: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:10085124"; MUTAGEN 417; /note="H->A: No effect."; /evidence="ECO:0000269|PubMed:10085124"; MUTAGEN 615; /note="D->A: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:10085124"; MUTAGEN 632; /note="R->A: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:10085124
uniprot
proteins
pubmed
10085124
uniprot
proteins
pubmed
10358058
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
16617059
uniprot
proteins
sequence_length
781
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm, cytosol {ECO:0000269|PubMed:16617059}. Mitochondrion membrane {ECO:0000269|PubMed:16617059}; Peripheral membrane protein. Early endosome membrane {ECO:0000269|PubMed:16617059}; Peripheral membrane protein. Note=Translocates to membrane vesicles in a calcium-dependent fashion. {ECO:0000269|PubMed:16617059}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm, cytosol {ECO:0000269|PubMed:16617059}.
uniprot
proteins