Smurf1
entrez
75788
canonical
uniprot
Q9CUN6
canonical
ensembl
ENSMUSG00000038780
resolver
ensp
ENSMUSP00000082827
resolver
ensp
ENSMUSP00000098029
resolver
ensp
ENSMUSP00000106305
resolver
ensp
ENSMUSP00000198561
resolver
ensp
ENSMUSP00000198572
resolver
enst
ENSMUST00000085684
resolver
enst
ENSMUST00000100461
resolver
enst
ENSMUST00000110677
resolver
genesymbol
Smurf1
resolver
uniprot
E9PYU8
resolver
uniprot
E9Q4K9
resolver
uniprot
Q3U412
resolver
uniprot
Q8BSC0
resolver
uniprot
Q8K300
resolver
uniprot_entry
E9PYU8_MOUSE
resolver
uniprot_entry
E9Q4K9_MOUSE
resolver
uniprot_entry
Q8BSC0_MOUSE
resolver
uniprot_entry
SMUF1_MOUSE
resolver
uniprot_sec
Q3U412
resolver
uniprot_sec
Q8K300
resolver
amino_acid_sequence
MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGGGGSVVDCRGLLENEGTVYEDSGPGRPLSCLMEEPAPYTDGTGAAAGGGNCRFVESPSQDQRLLVQRLRNPEVRGPLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLQLPSEGSVEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
uniprot
proteins
ec_number
2.3.2.26
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway (By similarity). Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway (By similarity). Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA (By similarity). Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404). Acts as a positive regulator of smoothened signaling pathway by mediating ubiquitination of PTCH1, leading to endocytosis and lysosomal degradation of PTCH1 (PubMed:24925320). Acts as an antagonist of TGF-beta signaling by ubiquitinating TGFBR1 and targeting it for degradation (By similarity). Plays a role in dendrite formation by melanocytes (By similarity). {ECO:0000250|UniProtKB:Q9HCE7, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:24925320}.
uniprot
proteins
mass_dalton
83356
uniprot
proteins
mutagenesis
MUTAGEN 699; /note="C->A: Abolished E3 ubiquitin-protein ligase activity and ability to ubiquitinate PTCH1."; /evidence="ECO:0000269|PubMed:24925320
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:24925320}.
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated in presence of NDFIP1. Ubiquitinated by the SCF(FBXL15) complex at Lys-355 and Lys-357, leading to its degradation by the proteasome. Lys-357 is the primary ubiquitination site. {ECO:0000250|UniProtKB:Q9HCE7}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23087404
uniprot
proteins
pubmed
24925320
uniprot
proteins
sequence_length
731
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9HCE7}. Cell membrane {ECO:0000250|UniProtKB:Q9HCE7}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9HCE7}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9HCE7}.
uniprot
proteins