Srp68
entrez
217337
canonical
uniprot
Q8BMA6
canonical
ensembl
ENSMUSG00000020780
resolver
ensp
ENSMUSP00000021133
resolver
enst
ENSMUST00000021133
resolver
genesymbol
Srp68
resolver
uniprot
A2AAN1
resolver
uniprot
Q6NS76
resolver
uniprot_entry
SRP68_MOUSE
resolver
uniprot_sec
A2AAN1
resolver
uniprot_sec
Q6NS76
resolver
amino_acid_sequence
MAAEKQIPGGGSGGGGSGSGGGGGGSGGGRSAGGDENKENERPSAGSKANKEFGDSLSLEILQIIKESQQQHGLRHGDFQRYRGYCSRRQRRLRKTLNFKMGNRHKFTGKKVTEELLTDNRYLLLVLMDAERAWSYAMQLKQEANTEPRKRFHLLSRLRKAVKHAEELERLCESNRVDAKTKLEAQAYTAYLSGMLRFEHQEWKSAIEAFNKCKTIYEKLASAFTEEQAVLYNQRVEEISPNIRYCAYNIGDQSAINELMQMRLRSGGTEGLLAEKLEALITQTRAKQAATMSEVEWRGRTVPVKIDKVRIFLLGLADNEAAIVQAESEETKERLFESMLSECRDALQAVREELKPDQKQRDYALDGESGKVSNLQYLHSYLTYIKLSTAIRRNENMAKGLHRALLQQQPEDDSKRSPRPQDLIRLYDIILQNLVELLQLPGLEEDRTFQKEISLKTLVFKAYRCFFIAQSYVLVKKWSEALVLYDRVLKYANEVSSHGGASKNSLKDLPDVQELITQVRSEKCSLQAAAILDANDSHQTDTSSQVKDNTPLVERFESFCLDPSLVTKQANLVHFPPGFQPIPCKPLFFDLALNHVAFPPLEDKLEQKTKSGLTGYIKGIFGFRS
uniprot
proteins
function
FUNCTION: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER (By similarity). The SRP complex targets the ribosome-nascent chain complex to the SRP receptor (SR), which is anchored in the ER, where SR compaction and GTPase rearrangement drive cotranslational protein translocation into the ER (By similarity). Binds the signal recognition particle RNA (7SL RNA), SRP72 binds to this complex subsequently (By similarity). The SRP complex possibly participates in the elongation arrest function (By similarity). {ECO:0000250|UniProtKB:P38687, ECO:0000250|UniProtKB:Q9UHB9}.
uniprot
proteins
mass_dalton
70574
uniprot
proteins
protein_family
SRP68 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
625
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UHB9}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9UHB9}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9UHB9}.
uniprot
proteins