CDO1
entrez
1036
canonical
uniprot
Q16878
canonical
ensembl
ENSG00000129596
resolver
ensp
ENSP00000250535
resolver
ensp
ENSP00000566831
resolver
ensp
ENSP00000566834
resolver
enst
ENST00000250535
resolver
genesymbol
CDO1
resolver
hgnc
HGNC:1795
resolver
uniprot
B2RAK4
resolver
uniprot
P78513
resolver
uniprot
Q6FHZ8
resolver
uniprot
Q8TB64
resolver
uniprot_entry
CDO1_HUMAN
resolver
uniprot_sec
B2RAK4
resolver
uniprot_sec
P78513
resolver
uniprot_sec
Q6FHZ8
resolver
uniprot_sec
Q8TB64
resolver
amino_acid_sequence
MEQTEVLKPRTLADLIRILHQLFAGDEVNVEEVQAIMEAYESDPTEWAMYAKFDQYRYTRNLVDQGNGKFNLMILCWGEGHGSSIHDHTNSHCFLKMLQGNLKETLFAWPDKKSNEMVKKSERVLRENQCAYINDSIGLHRVENISHTEPAVSLHLYSPPFDTCHAFDQRTGHKNKVTMTFHSKFGIRTPNATSGSLENN
uniprot
proteins
ec_number
1.13.11.20
uniprot
proteins
function
FUNCTION: Rate-limiting enzyme of the cysteine catabolic process to taurine, which catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen. {ECO:0000269|PubMed:17135237}.
uniprot
proteins
mass_dalton
22972
uniprot
proteins
mutagenesis
MUTAGEN 60; /note="R->Q: Reduces enzyme activity by 70%. Reduces iron and zinc incorporation by 50%."; /evidence="ECO:0000269|PubMed:17135237"; MUTAGEN 93; /note="C->S: Reduces enzyme activity and iron incorporation by 50%. Zinc incorporation increased by 20%."; /evidence="ECO:0000269|PubMed:17135237"; MUTAGEN 147; /note="H->A: Abolished interaction with LRRC58 and subsequent ubiquitination."; /evidence="ECO:0000269|PubMed:40963025"; MUTAGEN 148; /note="T->A: Decreased interaction with LRRC58 and subsequent ubiquitination."; /evidence="ECO:0000269|PubMed:40963025"; MUTAGEN 157; /note="Y->F: Almost total loss of enzyme activity and iron incorporation. Reduces zinc incorporation by 20%."; /evidence="ECO:0000269|PubMed:17135237"; MUTAGEN 164; /note="C->S: Reduces enzyme activity by 20%. Little effect on iron incorporation. No effect on zinc incorporation."; /evidence="ECO:0000269|PubMed:17135237"; MUTAGEN 170; /note="R->A: Decreased interaction with LRRC58 and subsequent ubiquitination."; /evidence="ECO:0000269|PubMed:40963025
uniprot
proteins
pathway_participation
PATHWAY: Organosulfur biosynthesis; taurine biosynthesis; hypotaurine from L-cysteine: step 1/2. {ECO:0000269|PubMed:17135237}.
uniprot
proteins
post_translational_modification
PTM: The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe(2+) ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen. {ECO:0000269|PubMed:17135237}.; PTM: Ubiquitinated and degraded by the ECS(LRRC58) complex, leading to its degradation (PubMed:40963025). L-cysteine abundance regulates ECS(LRRC58)-mediated ubiquitination of CDO1: the complex promotes ubiquitination and degradation of CDO1 in presence of high level of cysteine, but not when cysteine abundance is low (PubMed:40963025). {ECO:0000269|PubMed:40963025}.
uniprot
proteins
protein_family
Cysteine dioxygenase family
uniprot
proteins
pubmed
10427686
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17135237
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
40963025
uniprot
proteins
pubmed
7524679
uniprot
proteins
pubmed
9497919
uniprot
proteins
sequence_length
200
uniprot
proteins