Mcrs1
entrez
51812
canonical
uniprot
Q99L90
canonical
ensembl
ENSMUSG00000037570
resolver
ensp
ENSMUSP00000043901
resolver
ensp
ENSMUSP00000131407
resolver
ensp
ENSMUSP00000283526
resolver
enst
ENSMUST00000041190
resolver
enst
ENSMUST00000163506
resolver
genesymbol
Mcrs1
resolver
genesymbol_syn
Msp58
resolver
uniprot
F6YYA3
resolver
uniprot
O35255
resolver
uniprot
Q32P11
resolver
uniprot
Q3TJY1
resolver
uniprot
Q3TYU7
resolver
uniprot_entry
F6YYA3_MOUSE
resolver
uniprot_entry
MCRS1_MOUSE
resolver
uniprot_entry
Q3TJY1_MOUSE
resolver
uniprot_entry
Q3TYU7_MOUSE
resolver
uniprot_sec
O35255
resolver
uniprot_sec
Q32P11
resolver
amino_acid_sequence
MDKDSQGLLDSSLMASGTASRSEDEESLAGQKRASSQALGTIPKRRSSSRFIKRKKFDDELVESSLAKSSTRVKGAGGVESGRCSGSEPSSSEKKKVSKAPSTPVPPSPAPTPGLTKRVKKSKQPLQVTKDLGRWKPADDLLLINAVLQTNDLTSVHLGVKFSCRFTLREVQERWYALLYDPVISKLACQAMRQLHPEAIAAIQSKALFSKAEEQLLSKVGSSSQPTLETFQDLLHTHPDAFYLARTAKALQAHWQLMKQYYLLEDQTVQPLPKGDQVLNFSDAEDLIDDSKLKDMRDEVLEHELTVADRRQKREIRQLEQELHKWQVLVDSITGMGSPDFDNQTLAVLRGRMVRYLMRSREITLGRATKDNQIDVDLSLEGPAWKISRKQGVIKLKNNGDFFIANEGRRPIYIDGRPVLCGSKWRLSNNSVVEIASLRFVFLINQDLIALIRAEAAKITPQ
uniprot
proteins
function
FUNCTION: Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (By similarity). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair (By similarity). May also be an inhibitor of TERT telomerase activity (By similarity). Binds to G-quadruplex structures in mRNA. Binds to RNA homomer poly(G) and poly(U) (By similarity). Maintains RHEB at the lysosome in its active GTP-bound form and prevents its interaction with the mTORC1 complex inhibitor TSC2, ensuring activation of the mTORC1 complex by RHEB (By similarity). Stabilizes the minus ends of kinetochore fibers by protecting them from depolymerization, ensuring functional spindle assembly during mitosis (By similarity). Following phosphorylation by TTK/MPS1, enhances recruitment of KIF2A to the minus ends of mitotic spindle microtubules which promotes chromosome alignment (By similarity). Regulates the morphology of microtubule minus ends in mitotic spindle by maintaining them in a closed conformation characterized by the presence of an electron-dense cap (By similarity). Regulates G2/M transition and spindle assembly during oocyte meiosis (PubMed:36951681). Mediates histone modifications and transcriptional regulation in germinal vesicle oocytes which are required for meiotic progression (PubMed:36951681). Also regulates microtubule nucleation and spindle assembly by activating aurora kinases during oocyte meiosis (PubMed:36951681). Contributes to the establishment of centriolar satellites and also plays a role in primary cilium formation by recruiting TTBK2 to the mother centriole which is necessary for removal of the CP110 cap from the mother centriole, an early step in ciliogenesis (By similarity). Required for epiblast development during early embryogenesis (PubMed:31671403). Essential for cell viability (By similarity). {ECO:0000250|UniProtKB:Q96EZ8, ECO:0000269|PubMed:31671403, ECO:0000269|PubMed:36951681}.
uniprot
proteins
mass_dalton
51692
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by UBR5 when not assembled in the INO80 complex, leading to its degradation: UBR5 recognizes and binds a degron that is not accessible when MCRS1 is part of the INO80 complex. {ECO:0000250|UniProtKB:Q96EZ8}.; PTM: Phosphorylated by AURKA on Ser-35 and/or Ser-36 during mitosis which is required for kinetochore fiber assembly and mitotic progression but not for spindle localization or for chromosome-induced microtubule aster formation. Also phosphorylated by AURKA on Ser-85 and/or Ser-87. Phosphorylated by TTK/MPS1 which enhances recruitment of KIF2A to the minus end of spindle microtubules and facilitates precise chromosome segregation. {ECO:0000250|UniProtKB:Q96EZ8}.
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
31671403
uniprot
proteins
pubmed
36951681
uniprot
proteins
pubmed
9654073
uniprot
proteins
sequence_length
462
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31671403, ECO:0000269|PubMed:36951681}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q96EZ8}. Cytoplasm {ECO:0000269|PubMed:31671403}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q96EZ8}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:36951681}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q96EZ8}. Chromosome {ECO:0000269|PubMed:36951681}. Lysosome {ECO:0000250|UniProtKB:Q96EZ8}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000250|UniProtKB:Q96EZ8}. Note=Predominantly concentrated in the nucleus but also localizes to the centrosome (By similarity). Detected on the spindle poles during mitosis from prometaphase to telophase (By similarity). Found in microspherules in the nucleolus (By similarity). Localizes to lysosomes under high amino acid concentration conditions (By similarity). Localizes to the minus ends of kinetochore fibers and chromosomal microtubules (By similarity). Present in the nucleus of germinal vesicle oocytes and associates with spindles poles and chromosomes after germinal vesicle breakdown (PubMed:36951681). Present in cytoplasm and nucleus from the oocyte through to the two-cell stage (PubMed:31671403). By the four-cell stage, appears more concentrated in the nucleus and, by the blastocyst stage, becomes notably concentrated in the nuclei of cells of the inner cell mass compared with the trophectoderm (PubMed:31671403). {ECO:0000250|UniProtKB:Q96EZ8, ECO:0000269|PubMed:31671403, ECO:0000269|PubMed:36951681}.
uniprot
proteins