EDF1
entrez
8721
canonical
uniprot
O60869
canonical
ensembl
ENSG00000107223
resolver
ensp
ENSP00000224073
resolver
ensp
ENSP00000360711
resolver
ensp
ENSP00000360712
resolver
ensp
ENSP00000551267
resolver
ensp
ENSP00000551269
resolver
genesymbol
EDF1
resolver
hgnc
HGNC:3164
resolver
uniprot
Q5T5T2
resolver
uniprot
Q9UIM1
resolver
uniprot_entry
EDF1_HUMAN
resolver
uniprot_sec
Q5T5T2
resolver
uniprot_sec
Q9UIM1
resolver
amino_acid_sequence
MAESDWDTVTVLRKKGPTAAQAKSKQAILAAQRRGEDVETSKKWAAGQNKQHSITKNTAKLDRETEELHHDRVTLEVGKVIQQGRQSKGLTQKDLATKINEKPQVIADYESGRAIPNNQVLGKIERAIGLKLRGKDIGKPIEKGPRAK
uniprot
proteins
function
FUNCTION: Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism. {ECO:0000269|PubMed:10567391, ECO:0000269|PubMed:12040021, ECO:0000269|PubMed:15112053, ECO:0000269|PubMed:9813014}.
uniprot
proteins
mass_dalton
16369
uniprot
proteins
mutagenesis
MUTAGEN 40; /note="T->D: Loss of interaction with CALM; when associated with D-58; D-91 and D-111."; /evidence="ECO:0000269|PubMed:10816571"; MUTAGEN 58; /note="T->D: Loss of interaction with CALM; when associated with D-40; D-91 and D-111."; /evidence="ECO:0000269|PubMed:10816571"; MUTAGEN 65; /note="T->D: No effect on CALM-binding. No effect; when associated with D-74."; /evidence="ECO:0000269|PubMed:15112053"; MUTAGEN 74; /note="T->D: No effect on CALM-binding. No effect; when associated with D-65."; /evidence="ECO:0000269|PubMed:15112053"; MUTAGEN 87; /note="S->A: No effect on CALM-binding."; /evidence="ECO:0000269|PubMed:15112053"; MUTAGEN 87; /note="S->D: Loss of interaction with CALM and higher affinity for TBP. Same effect; when associated with D-65 and D-74."; /evidence="ECO:0000269|PubMed:15112053"; MUTAGEN 91; /note="T->A: No effect on CALM-binding."; /evidence="ECO:0000269|PubMed:10816571"; MUTAGEN 91; /note="T->D: Partial loss of interaction with CALM. Complete loss of interaction; when associated with D-40; D-58 and D-111."; /evidence="ECO:0000269|PubMed:10816571"; MUTAGEN 111; /note="S->D: Loss of interaction with CALM; when associated with D-40; D-58 and D-91."; /evidence="ECO:0000269|PubMed:10816571
uniprot
proteins
post_translational_modification
PTM: Phosphorylated (by PKA and PKC). {ECO:0000269|PubMed:10816571, ECO:0000269|PubMed:15112053}.
uniprot
proteins
pubmed
10567391
uniprot
proteins
pubmed
10816571
uniprot
proteins
pubmed
12040021
uniprot
proteins
pubmed
15112053
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
9813014
uniprot
proteins
sequence_length
148
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Also nuclear upon binding to NR5A1 and treatment of cells with TPA or forskolin.
uniprot
proteins