KDM3A
entrez
55818
canonical
uniprot
Q9Y4C1
canonical
ensembl
ENSG00000115548
resolver
ensp
ENSP00000323659
resolver
ensp
ENSP00000386516
resolver
ensp
ENSP00000386660
resolver
ensp
ENSP00000570260
resolver
ensp
ENSP00000626001
resolver
enst
ENST00000312912
resolver
enst
ENST00000409064
resolver
enst
ENST00000409556
resolver
enst
ENST00000900201
resolver
enst
ENST00000955942
resolver
genesymbol
KDM3A
resolver
genesymbol_syn
JHDM2A
resolver
genesymbol_syn
JMJD1
resolver
genesymbol_syn
JMJD1A
resolver
genesymbol_syn
KIAA0742
resolver
genesymbol_syn
TSGA
resolver
hgnc
HGNC:20815
resolver
uniprot
D6W5M3
resolver
uniprot
Q53S72
resolver
uniprot
Q68D47
resolver
uniprot
Q68UT9
resolver
uniprot
Q6N050
resolver
uniprot
Q8IY08
resolver
uniprot_entry
KDM3A_HUMAN
resolver
uniprot_sec
D6W5M3
resolver
uniprot_sec
Q53S72
resolver
uniprot_sec
Q68D47
resolver
uniprot_sec
Q68UT9
resolver
uniprot_sec
Q6N050
resolver
uniprot_sec
Q8IY08
resolver
amino_acid_sequence
MVLTLGESWPVLVGRRFLSLSAADGSDGSHDSWDVERVAEWPWLSGTIRAVSHTDVTKKDLKVCVEFDGESWRKRRWIEVYSLLRRAFLVEHNLVLAERKSPEISERIVQWPAITYKPLLDKAGLGSITSVRFLGDQQRVFLSKDLLKPIQDVNSLRLSLTDNQIVSKEFQALIVKHLDESHLLKGDKNLVGSEVKIYSLDPSTQWFSATVINGNPASKTLQVNCEEIPALKIVDPSLIHVEVVHDNLVTCGNSARIGAVKRKSSENNGTLVSKQAKSCSEASPSMCPVQSVPTTVFKEILLGCTAATPPSKDPRQQSTPQAANSPPNLGAKIPQGCHKQSLPEEISSCLNTKSEALRTKPDVCKAGLLSKSSQIGTGDLKILTEPKGSCTQPKTNTDQENRLESVPQALTGLPKECLPTKASSKAELEIANPPELQKHLEHAPSPSDVSNAPEVKAGVNSDSPNNCSGKKVEPSALACRSQNLKESSVKVDNESCCSRSNNKIQNAPSRKSVLTDPAKLKKLQQSGEAFVQDDSCVNIVAQLPKCRECRLDSLRKDKEQQKDSPVFCRFFHFRRLQFNKHGVLRVEGFLTPNKYDNEAIGLWLPLTKNVVGIDLDTAKYILANIGDHFCQMVISEKEAMSTIEPHRQVAWKRAVKGVREMCDVCDTTIFNLHWVCPRCGFGVCVDCYRMKRKNCQQGAAYKTFSWLKCVKSQIHEPENLMPTQIIPGKALYDVGDIVHSVRAKWGIKANCPCSNRQFKLFSKPASKEDLKQTSLAGEKPTLGAVLQQNPSVLEPAAVGGEAASKPAGSMKPACPASTSPLNWLADLTSGNVNKENKEKQPTMPILKNEIKCLPPLPPLSKSSTVLHTFNSTILTPVSNNNSGFLRNLLNSSTGKTENGLKNTPKILDDIFASLVQNKTTSDLSKRPQGLTIKPSILGFDTPHYWLCDNRLLCLQDPNNKSNWNVFRECWKQGQPVMVSGVHHKLNSELWKPESFRKEFGEQEVDLVNCRTNEIITGATVGDFWDGFEDVPNRLKNEKEPMVLKLKDWPPGEDFRDMMPSRFDDLMANIPLPEYTRRDGKLNLASRLPNYFVRPDLGPKMYNAYGLITPEDRKYGTTNLHLDVSDAANVMVYVGIPKGQCEQEEEVLKTIQDGDSDELTIKRFIEGKEKPGALWHIYAAKDTEKIREFLKKVSEEQGQENPADHDPIHDQSWYLDRSLRKRLHQEYGVQGWAIVQFLGDVVFIPAGAPHQVHNLYSCIKVAEDFVSPEHVKHCFWLTQEFRYLSQTHTNHEDKLQVKNVIYHAVKDAVAMLKASESSFGKP
uniprot
proteins
ec_number
1.14.11.65
uniprot
proteins
function
FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1. {ECO:0000269|PubMed:16603237, ECO:0000269|PubMed:28262558}.
uniprot
proteins
mass_dalton
147341
uniprot
proteins
mutagenesis
MUTAGEN 1120; /note="H->A: Abolishes lysine-specific histone demethylase activity."; /evidence="ECO:0000269|PubMed:28262558"; MUTAGEN 1120; /note="H->Y: Abolishes histone demethylase activity."; /evidence="ECO:0000269|PubMed:16603237
uniprot
proteins
protein_family
JHDM2 histone demethylase family
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16603237
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28262558
uniprot
proteins
pubmed
37179361
uniprot
proteins
pubmed
9872452
uniprot
proteins
sequence_length
1321
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Nuclear in round spermatids. When spermatids start to elongate, localizes to the cytoplasm where it forms distinct foci which disappear in mature spermatozoa (By similarity). {ECO:0000250}.
uniprot
proteins