HEL2
entrez
7531
canonical
uniprot
P62258
canonical
ensembl
ENSG00000108953
resolver
ensembl
ENSG00000274474
resolver
ensp
ENSP00000264335
resolver
genesymbol
HEL2
resolver
genesymbol
YWHAE
resolver
hgnc
HGNC:12851
resolver
uniprot
B3KY71
resolver
uniprot
D3DTH5
resolver
uniprot
P29360
resolver
uniprot
P42655
resolver
uniprot
Q4VJB6
resolver
uniprot
Q53XZ5
resolver
uniprot
Q63631
resolver
uniprot
Q7M4R4
resolver
uniprot
V9HW98
resolver
uniprot_entry
1433E_HUMAN
resolver
uniprot_entry
V9HW98_HUMAN
resolver
uniprot_sec
B3KY71
resolver
uniprot_sec
D3DTH5
resolver
uniprot_sec
P29360
resolver
uniprot_sec
P42655
resolver
uniprot_sec
Q4VJB6
resolver
uniprot_sec
Q53XZ5
resolver
uniprot_sec
Q63631
resolver
uniprot_sec
Q7M4R4
resolver
amino_acid_sequence
MDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDGEEQNKEALQDVEDENQ
uniprot
proteins
function
FUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:21189250). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:35343654). Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). Plays a positive role in the antiviral signaling pathway upstream of TBK1 via interaction with RIGI (PubMed:37555661). Mechanistically, directs RIGI redistribution from the cytosol to mitochondrial associated membranes where it mediates MAVS-dependent innate immune signaling during viral infection (PubMed:22607805). Plays a role in proliferation inhibition and cell cycle arrest by exporting HNRNPC from the nucleus to the cytoplasm to be degraded by ubiquitination (PubMed:37599448). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:21189250, ECO:0000269|PubMed:22607805, ECO:0000269|PubMed:35343654, ECO:0000269|PubMed:37555661, ECO:0000269|PubMed:37599448}.
uniprot
proteins
mass_dalton
29174
uniprot
proteins
mutagenesis
MUTAGEN 236; /note="Q->A: Complete loss of cleavage by poliovirus protease 3C."; /evidence="ECO:0000269|PubMed:37555661
uniprot
proteins
post_translational_modification
PTM: (Microbial infection) Cleaved by poliovirus protease 3C, leading to disruption of the interaction with RIGI. {ECO:0000269|PubMed:37555661}.
uniprot
proteins
protein_family
14-3-3 family
uniprot
proteins
pubmed
10409742
uniprot
proteins
pubmed
10644344
uniprot
proteins
pubmed
11427721
uniprot
proteins
pubmed
12042314
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
12917326
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15696159
uniprot
proteins
pubmed
15722337
uniprot
proteins
pubmed
16376338
uniprot
proteins
pubmed
17081065
uniprot
proteins
pubmed
17085597
uniprot
proteins
pubmed
18029012
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
19172738
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19592491
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19640509
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
2026444
uniprot
proteins
pubmed
20417184
uniprot
proteins
pubmed
21189250
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22607805
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23572552
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25588844
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26047703
uniprot
proteins
pubmed
26055712
uniprot
proteins
pubmed
27030597
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
29769719
uniprot
proteins
pubmed
30611118
uniprot
proteins
pubmed
35343654
uniprot
proteins
pubmed
37555661
uniprot
proteins
pubmed
37599448
uniprot
proteins
pubmed
7644510
uniprot
proteins
pubmed
8684458
uniprot
proteins
pubmed
8858348
uniprot
proteins
sequence_length
255
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12917326, ECO:0000269|PubMed:37599448}. Cytoplasm {ECO:0000269|PubMed:12917326}. Melanosome {ECO:0000269|PubMed:12042314, ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000269|PubMed:12042314, ECO:0000269|PubMed:17081065}.
uniprot
proteins