CSF2RB
entrez
1439
canonical
uniprot
P32927
canonical
ensembl
ENSG00000100368
resolver
ensp
ENSP00000384053
resolver
ensp
ENSP00000385271
resolver
ensp
ENSP00000580915
resolver
genesymbol
CSF2RB
resolver
genesymbol_syn
IL3RB
resolver
genesymbol_syn
IL5RB
resolver
hgnc
HGNC:2436
resolver
uniprot
Q5JZI1
resolver
uniprot
Q6ICE0
resolver
uniprot
Q6NSJ8
resolver
uniprot_entry
IL3RB_HUMAN
resolver
uniprot_entry
Q6NSJ8_HUMAN
resolver
uniprot_sec
Q5JZI1
resolver
uniprot_sec
Q6ICE0
resolver
amino_acid_sequence
MVLAQGLLSMALLALCWERSLAGAEETIPLQTLRCYNDYTSHITCRWADTQDAQRLVNVTLIRRVNEDLLEPVSCDLSDDMPWSACPHPRCVPRRCVIPCQSFVVTDVDYFSFQPDRPLGTRLTVTLTQHVQPPEPRDLQISTDQDHFLLTWSVALGSPQSHWLSPGDLEFEVVYKRLQDSWEDAAILLSNTSQATLGPEHLMPSSTYVARVRTRLAPGSRLSGRPSKWSPEVCWDSQPGDEAQPQNLECFFDGAAVLSCSWEVRKEVASSVSFGLFYKPSPDAGEEECSPVLREGLGSLHTRHHCQIPVPDPATHGQYIVSVQPRRAEKHIKSSVNIQMAPPSLNVTKDGDSYSLRWETMKMRYEHIDHTFEIQYRKDTATWKDSKTETLQNAHSMALPALEPSTRYWARVRVRTSRTGYNGIWSEWSEARSWDTESVLPMWVLALIVIFLTIAVLLALRFCGIYGYRLRRKWEEKIPNPSKSHLFQNGSAELWPPGSMSAFTSGSPPHQGPWGSRFPELEGVFPVGFGDSEVSPLTIEDPKHVCDPPSGPDTTPAASDLPTEQPPSPQPGPPAASHTPEKQASSFDFNGPYLGPPHSRSLPDILGQPEPPQEGGSQKSPPPGSLEYLCLPAGGQVQLVPLAQAMGPGQAVEVERRPSQGAAGSPSLESGGGPAPPALGPRVGGQDQKDSPVAIPMSSGDTEDPGVASGYVSSADLVFTPNSGASSVSLVPSLGLPSDQTPSLCPGLASGPPGAPGPVKSGFEGYVELPPIEGRSPRSPRNNPVPPEAKSPVLNPGERPADVSPTSPQPEGLLVLQQVGDYCFLPGLGPGPLSLRSKPSSPGPGPEIKNLDQAFQVKKPPGQAVPQVPVIQLFKALKQQDYLSLPPWEVNKPGEVC
uniprot
proteins
disease_involvement
DISEASE: Pulmonary surfactant metabolism dysfunction 5 (SMDP5) [MIM:614370]: A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. {ECO:0000269|PubMed:21075760}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Cell surface receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Acts by forming an heterodimeric receptor through interaction with different partners such as IL3RA, IL5RA or CSF2RA (PubMed:1495999). In turn, participates in various signaling pathways including interleukin-3, interleukin-5 and granulocyte-macrophage colony-stimulating factor/CSF2 pathways. In unstimulated conditions, interacts constitutively with JAK1 and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway (PubMed:9516124). {ECO:0000269|PubMed:1495999, ECO:0000269|PubMed:9516124}.
uniprot
proteins
mass_dalton
97336
uniprot
proteins
post_translational_modification
PTM: May be phosphorylated by LYN. {ECO:0000250}.
uniprot
proteins
protein_family
Type 4 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
10736232
uniprot
proteins
pubmed
10753826
uniprot
proteins
pubmed
11207369
uniprot
proteins
pubmed
1495999
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
16754968
uniprot
proteins
pubmed
1702217
uniprot
proteins
pubmed
17828305
uniprot
proteins
pubmed
18692472
uniprot
proteins
pubmed
21075760
uniprot
proteins
pubmed
9410898
uniprot
proteins
pubmed
9516124
uniprot
proteins
sequence_length
897
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 444..460; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins