MATN1
entrez
4146
canonical
uniprot
P21941
canonical
ensembl
ENSG00000162510
resolver
ensp
ENSP00000362870
resolver
enst
ENST00000373765
resolver
genesymbol
MATN1
resolver
genesymbol_syn
CMP
resolver
genesymbol_syn
CRTM
resolver
hgnc
HGNC:6907
resolver
uniprot
B2R7E3
resolver
uniprot
Q5TBB9
resolver
uniprot_entry
MATN1_HUMAN
resolver
uniprot_sec
B2R7E3
resolver
uniprot_sec
Q5TBB9
resolver
amino_acid_sequence
MRVLSGTSLMLCSLLLLLQALCSPGLAPQSRGHLCRTRPTDLVFVVDSSRSVRPVEFEKVKVFLSQVIESLDVGPNATRVGMVNYASTVKQEFSLRAHVSKAALLQAVRRIQPLSTGTMTGLAIQFAITKAFGDAEGGRSRSPDISKVVIVVTDGRPQDSVQDVSARARASGVELFAIGVGSVDKATLRQIASEPQDEHVDYVESYSVIEKLSRKFQEAFCVVSDLCATGDHDCEQVCISSPGSYTCACHEGFTLNSDGKTCNVCSGGGGSSATDLVFLIDGSKSVRPENFELVKKFISQIVDTLDVSDKLAQVGLVQYSSSVRQEFPLGRFHTKKDIKAAVRNMSYMEKGTMTGAALKYLIDNSFTVSSGARPGAQKVGIVFTDGRSQDYINDAAKKAKDLGFKMFAVGVGNAVEDELREIASEPVAEHYFYTADFKTINQIGKKLQKKICVEEDPCACESLVKFQAKVEGLLQALTRKLEAVSKRLAILENTVV
uniprot
proteins
function
FUNCTION: A major component of the extracellular matrix of non-articular cartilage (By similarity). Binds to type 2 collagens and forms long concatenated protein networks as part of the extracellular matrix (By similarity). Required for the network-like organization and bundling of collagen fibrils surrounding chondrocytes in the zones of maturation and hypertrophy (By similarity). Required for mechanotransduction and adaption to mechanical loading in cartilage chondrocytes, resulting in an increase in expression of the extracellular matrix components ACAN and COL2A1 (By similarity). Acts as a moderator of angiogenesis in response to injury (By similarity). {ECO:0000250|UniProtKB:P05099, ECO:0000250|UniProtKB:P51942}.
uniprot
proteins
mass_dalton
53701
uniprot
proteins
mutagenesis
MUTAGEN 76; /note="N->A: Abolishes N-glycosylation; no effect on protein secretion and increases interaction with type 2 collagens."; /evidence="ECO:0000269|PubMed:20729554"; MUTAGEN 344; /note="N->A: Abolishes N-glycosylation; no effect on protein secretion and increases interaction with type 2 collagens."; /evidence="ECO:0000269|PubMed:20729554
uniprot
proteins
post_translational_modification
PTM: N-glycosylated; reduces binding affinity for type 2 collagens. {ECO:0000269|PubMed:20729554}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15075323
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
20729554
uniprot
proteins
pubmed
2246248
uniprot
proteins
sequence_length
496
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P05099}.
uniprot
proteins