Dab1
entrez
13131
canonical
uniprot
P97318
canonical
ensembl
ENSMUSG00000028519
resolver
ensp
ENSMUSP00000102439
resolver
ensp
ENSMUSP00000102440
resolver
ensp
ENSMUSP00000102443
resolver
ensp
ENSMUSP00000246581
resolver
ensp
ENSMUSP00000246582
resolver
ensp
ENSMUSP00000246588
resolver
ensp
ENSMUSP00000246589
resolver
ensp
ENSMUSP00000246592
resolver
ensp
ENSMUSP00000246593
resolver
ensp
ENSMUSP00000246594
resolver
ensp
ENSMUSP00000246595
resolver
ensp
ENSMUSP00000246596
resolver
ensp
ENSMUSP00000246597
resolver
ensp
ENSMUSP00000246600
resolver
ensp
ENSMUSP00000246604
resolver
ensp
ENSMUSP00000246605
resolver
ensp
ENSMUSP00000246611
resolver
ensp
ENSMUSP00000246612
resolver
ensp
ENSMUSP00000246620
resolver
ensp
ENSMUSP00000246633
resolver
genesymbol
Dab1
resolver
uniprot
A2A963
resolver
uniprot
A2A964
resolver
uniprot
A2A965
resolver
uniprot
A2A966
resolver
uniprot
A2A967
resolver
uniprot
A2A970
resolver
uniprot
B2RRQ8
resolver
uniprot
P97316
resolver
uniprot
P97317
resolver
uniprot
Q9DAP9
resolver
uniprot_entry
B2RRQ8_MOUSE
resolver
uniprot_entry
DAB1_MOUSE
resolver
uniprot_sec
A2A963
resolver
uniprot_sec
A2A964
resolver
uniprot_sec
A2A965
resolver
uniprot_sec
A2A966
resolver
uniprot_sec
A2A967
resolver
uniprot_sec
A2A970
resolver
uniprot_sec
P97316
resolver
uniprot_sec
P97317
resolver
uniprot_sec
Q9DAP9
resolver
amino_acid_sequence
MSTETELQVAVKTSAKKDSRKKGQDRSEATLIKRFKGEGVRYKAKLIGIDEVSAARGDKLCQDSMMKLKGVVAGARSKGEHKQKIFLTISFGGIKIFDEKTGALQHHHAVHEISYIAKDITDHRAFGYVCGKEGNHRFVAIKTAQAAEPVILDLRDLFQLIYELKQREELEKKAQKDKQCEQAVYQTILEEDVEDPVYQYIVFEAGHEPIRDPETEENIYQVPTSQKKEGVYDVPKSQPNSQPLEDFESRFAAATPNRNLSMDFDELLEATKVSAVTQLELFGDMSTPPDITSPPTPATPGDAFLPSSSQTLPGSADVFGSMSFGTAAVPSGYVAMGAVLPSFWGQQPLVQQQIAMGAQPPVAQVIPGAQPIAWGQPGLFPATQQAWPTVAGQFPPAAFMPTQTVMPLAAAMFQGPLTPLATVPGTNDSARSSPQSDKPRQKMGKESFKDFQMVQPPPVPSRKPDQPSLTCTSEAFSSYFNKVGVAQDTDDCDDFDISQLNLTPVTSTTPSTNSPPTPAPRQSSPSKSSASHVSDPTADDIFEEGFESPSKSEEQEAPDGSQASSTSDPFGEPSGEPSGDNISPQDGS
uniprot
proteins
function
FUNCTION: Signaling adapter of the reelin-mediated signaling pathway, which regulates the migration and differentiation of postmitotic neurons during brain development (PubMed:12526739, PubMed:9009273, PubMed:9338784, PubMed:9338785). Mediates intracellular transduction of Reelin signaling following reelin (RELN)-binding to its receptor: acts by docking proteins through its phosphotyrosine residues and PID domain (PubMed:12526739, PubMed:9009273, PubMed:9338784, PubMed:9338785). {ECO:0000269|PubMed:12526739, ECO:0000269|PubMed:9009273, ECO:0000269|PubMed:9338784, ECO:0000269|PubMed:9338785}.
uniprot
proteins
mass_dalton
63578
uniprot
proteins
mutagenesis
MUTAGEN 45; /note="K->A: Impairs binding to PtdIns(4,5)P2."; /evidence="ECO:0000269|PubMed:12826668"; MUTAGEN 82; /note="K->A: Abolishes binding to PtdIns(4,5)P2."; /evidence="ECO:0000269|PubMed:12826668"; MUTAGEN 114; /note="S->T: Abolishes interaction with APLP1."; /evidence="ECO:0000269|PubMed:12826668"; MUTAGEN 136; /note="H->R: Greatly impairs interaction with APLP1."; /evidence="ECO:0000269|PubMed:12826668"; MUTAGEN 158; /note="F->V: Abolishes interaction with APLP1."; /evidence="ECO:0000269|PubMed:12826668"; MUTAGEN 185; /note="Y->F: Reduces phosphorylation by SRC or downstream kinase; when associated with F-198 and F-200. Abolishes phosphorylation by SRC or downstream kinase; when associated with F-198; F-200; F-220 and F-232."; /evidence="ECO:0000269|PubMed:10959835"; MUTAGEN 198; /note="Y->F: Reduces phosphorylation by SRC or downstream kinase; when associated with F-185 and F-200. Abolishes phosphorylation by SRC or downstream kinase; when associated with F-185; F-200; F-220 and F-232."; /evidence="ECO:0000269|PubMed:10959835"; MUTAGEN 200; /note="Y->F: Reduces phosphorylation by SRC or downstream kinase; when associated with F-185 and F-198. Abolishes phosphorylation by SRC or downstream kinase; when associated with F-185; F-198; F-220 and F-232."; /evidence="ECO:0000269|PubMed:10959835"; MUTAGEN 220; /note="Y->F: Reduces phosphorylation by SRC or downstream kinase; when associated with F-232. Abolishes phosphorylation by SRC or downstream kinase; when associated with F-185; F-198; F-200 and F-232. Abolishes interaction with CRKLSH2 domain; when associated with F-232."; /evidence="ECO:0000269|PubMed:10959835, ECO:0000269|PubMed:15062102"; MUTAGEN 232; /note="Y->F: Reduces phosphorylation by SRC or downstream kinase; when associated with F-220. Abolishes phosphorylation by SRC or downstream kinase; when associated with F-185; F-198; F-200 and F-220. Abolishes interaction with CRKLSH2 domain; when associated with F-220."; /evidence="ECO:0000269|PubMed:10959835, ECO:0000269|PubMed:15062102
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by FYN on Tyr-198 and Tyr-220 upon reelin induction in embryonic neurons (PubMed:11279201, PubMed:12526739). Also found phosphorylated on Tyr-232 upon reelin induction (PubMed:15062102). Also phosphorylated on Ser-524 independently of reelin signaling. {ECO:0000269|PubMed:10959835, ECO:0000269|PubMed:11279201, ECO:0000269|PubMed:12077184, ECO:0000269|PubMed:12526739, ECO:0000269|PubMed:15062102}.; PTM: Ubiquitinated by various cullin-5-RING E3 ubiquitin-protein ligase complexes (ECS complexes) following ligand-binding and phosphorylation, leading to its degradation (PubMed:17974915, PubMed:24210661, PubMed:29361558). Ubiquitinated by the ECS(SOCS7) complex in the cortical plate of the developing cerebral cortex following ligand-binding and phosphorylation by FYN, leading to its degradation by the proteasome (PubMed:24210661). Recognized by ZSWIM8 through a disorder targets misorder mechanism that eliminates misfolded DAB1 via ubiquitination and proteasomal degradation (By similarity). {ECO:0000250|UniProtKB:O75553, ECO:0000269|PubMed:17974915, ECO:0000269|PubMed:24210661, ECO:0000269|PubMed:29361558}.
uniprot
proteins
pubmed
10959835
uniprot
proteins
pubmed
11279201
uniprot
proteins
pubmed
12077184
uniprot
proteins
pubmed
12526739
uniprot
proteins
pubmed
12646221
uniprot
proteins
pubmed
12737822
uniprot
proteins
pubmed
12826668
uniprot
proteins
pubmed
15062102
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17974915
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
24210661
uniprot
proteins
pubmed
29361558
uniprot
proteins
pubmed
35989311
uniprot
proteins
pubmed
9009273
uniprot
proteins
pubmed
9338784
uniprot
proteins
pubmed
9338785
uniprot
proteins
sequence_length
588
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9338785}.
uniprot
proteins