Avil
entrez
79253
canonical
uniprot
Q9WU06
canonical
ensembl
ENSRNOG00000050419
resolver
ensembl
ENSRNOG00055026100
resolver
ensembl
ENSRNOG00060010038
resolver
ensembl
ENSRNOG00065016046
resolver
ensp
ENSRNOP00000067218
resolver
ensp
ENSRNOP00055036951
resolver
ensp
ENSRNOP00060013247
resolver
ensp
ENSRNOP00065020915
resolver
enst
ENSRNOT00000073237
resolver
enst
ENSRNOT00055045053
resolver
enst
ENSRNOT00060016984
resolver
enst
ENSRNOT00065026666
resolver
genesymbol
Avil
resolver
genesymbol_syn
Advil
resolver
genesymbol_syn
Pervin
resolver
uniprot
M0RCA6
resolver
uniprot_entry
AVIL_RAT
resolver
uniprot_sec
M0RCA6
resolver
amino_acid_sequence
MSLSSAFRTVTNDPGIITWRIEKMELVLVPLSAHGNFYEGDCYIILSTRRVGSLLSQNIHFWIGKDSSQDEQSCAAIYTTQLDDYLGGSPVQHREVQYHESDTFRGYFKRGIIYKKGGVASGMKHVETNTYDVKRLLHVKGKRNIRATEVEMSWDSFNQGDVFLLDLGMVIIQWNGPESNSGERLKAMLLAKDIRDRERGGRAEIGVIEGDKEAASPELMTVLQNTLGRRSIIKPAVPDEVTDQQQKSTIMLYHVSDTTGQLSVTEVATRPLVQELLNHDDCYILDQSGTKIYVWKGKGATKVEKQAAMSKALDFIKMKGYPSSTNVETVNDGAESAMFKQLFQKWSVKDQTTGLGKTFSIGKIAKIFQDKFDVTLLHTKPEVAAQERMVDDGNGKVEVWRIENLELVPVEYQWHGFFYGGDCYLVLYTYDVNGKPCYILYIWQGRHASQDELAASAYQAVEVDQQFGGAPVQVRVSMGKEPRHFMAIFKGKLVIYEGGTSRKGNVEPDPPVRLFQIHGNDKSNTKAVEVSASASSLNSNDVFLLWTQAEHYLWYGKGSSGDERAMAKELAELLCDGDADTVAEGQEPPEFWDLLGGKAPYANDKRLQQETLDIQVRLFECSNKTGRFLVTEVTDFTQDDLSPGDVMLLDTWDQVFLWIGAEANATEKEGALSTAQEYLVTHPSGRDPDTPILIIKQGFEPPTFTGWFLAWDPHIWSEGKSYEQLKNELGDATAIVRITTDMKNATLSLNSSESGPKYYPVEVLLKSQDQELPEDVDPTKKENYLSERDFVSVFGITRGQFVSLPGWKQLQLKKEAGLF
uniprot
proteins
function
FUNCTION: Ca(2+)-regulated actin-binding protein which plays an important role in actin bundling. May have a unique function in the morphogenesis of neuronal cells which form ganglia. Required for SREC1-mediated regulation of neurite-like outgrowth. Plays a role in regenerative sensory axon outgrowth and remodeling processes after peripheral injury in neonates (PubMed:11849295). Involved in the formation of long fine actin-containing filopodia-like structures in fibroblast. Plays a role in ciliogenesis. In podocytes, controls lamellipodia formation through the regulation of EGF-induced diacylglycerol generation by PLCE1 and ARP2/3 complex assembly (By similarity). {ECO:0000250|UniProtKB:O75366, ECO:0000269|PubMed:11849295}.
uniprot
proteins
mass_dalton
91894
uniprot
proteins
protein_family
Villin/gelsolin family
uniprot
proteins
pubmed
11849295
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
29058690
uniprot
proteins
sequence_length
819
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11849295}. Cell projection, neuron projection {ECO:0000269|PubMed:11849295}. Cell projection, axon {ECO:0000269|PubMed:11849295}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:O75366}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:O75366}. Note=In podocytes, present in the F-actin-enriched cell periphery that generates lamellipodia and focal adhesions. {ECO:0000250|UniProtKB:O75366}.
uniprot
proteins