Cnga4
entrez
85258
canonical
uniprot
Q64359
canonical
ensembl
ENSRNOG00000017609
resolver
ensembl
ENSRNOG00055024034
resolver
ensembl
ENSRNOG00060017530
resolver
ensembl
ENSRNOG00065031797
resolver
ensp
ENSRNOP00000023751
resolver
ensp
ENSRNOP00055033580
resolver
ensp
ENSRNOP00060024158
resolver
ensp
ENSRNOP00065045026
resolver
enst
ENSRNOT00000023751
resolver
enst
ENSRNOT00055041272
resolver
enst
ENSRNOT00060029949
resolver
enst
ENSRNOT00065054760
resolver
genesymbol
Cnga4
resolver
genesymbol_syn
Cgn2
resolver
uniprot
G3V898
resolver
uniprot
Q6Q2I4
resolver
uniprot_entry
CNGA4_RAT
resolver
uniprot_entry
G3V898_RAT
resolver
uniprot_sec
Q6Q2I4
resolver
activity_regulation
ACTIVITY REGULATION: Ca(2+)-calmodulin exerts its inhibitory effect in cAMP sensitivity by binding to IQ-like motif of CNGA4 and preferably binds to the channel in the closed state. Inhibition by PIP3 of the CNG channel probably occurs via CGNA2 binding. Ca(2+) currents are inhibited by pimozide, an L-type Ca(2+) channel blocker. {ECO:0000269|PubMed:15134638, ECO:0000269|PubMed:15195096, ECO:0000269|PubMed:9208862}.
uniprot
proteins
amino_acid_sequence
MSQDGKVKTTESTPPAPTKARKWLPVLDPSGDYYYWWLNTMVFPIMYNLIIVVCRACFPDLQHSYLVAWFVLDYTSDLLYLLDIGVRFHTGFLEQGILVVDKGMIASRYVRTWSFLLDLASLVPTDAAYVQLGPHIPTLRLNRFLRVPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVIHWNSCLYFALSRYLGFGRDAWVYPDPAQPGFERLRRQYLYSFYFSTLILTTVGDTPLPDREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNKRLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGREMYIIREGQLAVVADDGVTQYAVLGAGLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQAQAVMEEKGREILLKMNKLDVNAEAAEIALQEATESRLKGLDQQLDDLQTKFARLLAELESSALKIAYRIERLEWQTREWPMPEDMGEADDEAEPGEGTSKDGEGKAGQAGPSGIE
uniprot
proteins
function
FUNCTION: Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants. Conducts cAMP- and cGMP-gated ion currents, with permeability for monovalent and divalent cations (PubMed:10377344, PubMed:15134638, PubMed:27405959, PubMed:7522325, PubMed:7522482, PubMed:9878057). May conduct nitric oxide-gated Ca(2+) currents relevant to neurons of vomeronasal organ, a system involved in the perception of pheromones (PubMed:9208862). {ECO:0000269|PubMed:10377344, ECO:0000269|PubMed:15134638, ECO:0000269|PubMed:27405959, ECO:0000269|PubMed:7522325, ECO:0000269|PubMed:7522482, ECO:0000269|PubMed:9208862, ECO:0000269|PubMed:9878057}.
uniprot
proteins
mass_dalton
65675
uniprot
proteins
mutagenesis
MUTAGEN 430; /note="R->E: Decreases the affnity of the channel for cGMP."; /evidence="ECO:0000269|PubMed:27405959
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:10377344}.
uniprot
proteins
protein_family
CNGA4 subfamily
uniprot
proteins
protein_family
Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family
uniprot
proteins
pubmed
10377344
uniprot
proteins
pubmed
11764791
uniprot
proteins
pubmed
15134638
uniprot
proteins
pubmed
15195096
uniprot
proteins
pubmed
27405959
uniprot
proteins
pubmed
7522325
uniprot
proteins
pubmed
7522482
uniprot
proteins
pubmed
9208862
uniprot
proteins
pubmed
9878057
uniprot
proteins
sequence_length
575
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000305|PubMed:10377344}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 39..60; /note="Helical; Name=S1"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 71..91; /note="Helical; Name=S2"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 117..135; /note="Helical; Name=S3"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 141..159; /note="Helical; Name=S4"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 167..190; /note="Helical; Name=S5"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 214..248; /note="Helical; Name=P-helix"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 249..273; /note="Helical; Name=S6"; /evidence="ECO:0000250|UniProtKB:P29973
uniprot
proteins