MLANA
entrez
2315
canonical
uniprot
Q16655
canonical
ensembl
ENSG00000120215
resolver
ensp
ENSP00000370880
resolver
ensp
ENSP00000370885
resolver
ensp
ENSP00000370886
resolver
enst
ENST00000381471
resolver
enst
ENST00000381476
resolver
enst
ENST00000381477
resolver
genesymbol
MLANA
resolver
genesymbol_syn
MART1
resolver
hgnc
HGNC:7124
resolver
uniprot
A0A384MR46
resolver
uniprot
Q6ICU4
resolver
uniprot_entry
A0A384MR46_HUMAN
resolver
uniprot_entry
MAR1_HUMAN
resolver
uniprot_sec
Q6ICU4
resolver
amino_acid_sequence
MPREDAHFIYGYPKKGHGHSYTTAEEAAGIGILTVILGVLLLIGCWYCRRRNGYRALMDKSLHVGTQCALTRRCPQEGFDHRDSKVSLQEKNCEPVVPNAPPAYEKLSAEQSPPPYSP
uniprot
proteins
function
FUNCTION: Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes. {ECO:0000269|PubMed:15695812, ECO:0000269|PubMed:19717472}.
uniprot
proteins
mass_dalton
13157
uniprot
proteins
post_translational_modification
PTM: Acylated. {ECO:0000269|PubMed:12191019}.
uniprot
proteins
pubmed
11551907
uniprot
proteins
pubmed
12191019
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15695812
uniprot
proteins
pubmed
19717472
uniprot
proteins
pubmed
20417641
uniprot
proteins
pubmed
8006593
uniprot
proteins
pubmed
8170938
uniprot
proteins
sequence_length
118
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Note=Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.
uniprot
proteins
transmembrane_region
TRANSMEM 27..47; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins