Itgb1bp1
entrez
16413
canonical
uniprot
O35671
canonical
ensembl
ENSMUSG00000062352
resolver
ensp
ENSMUSP00000075609
resolver
ensp
ENSMUSP00000134627
resolver
ensp
ENSMUSP00000156312
resolver
ensp
ENSMUSP00000174573
resolver
ensp
ENSMUSP00000174574
resolver
ensp
ENSMUSP00000174575
resolver
enst
ENSMUST00000076260
resolver
enst
ENSMUST00000173729
resolver
enst
ENSMUST00000232072
resolver
genesymbol
Itgb1bp1
resolver
uniprot
Q542A8
resolver
uniprot_entry
ITBP1_MOUSE
resolver
uniprot_sec
Q542A8
resolver
amino_acid_sequence
MFRKGKKRHSSSSSQSSEISTKSKSVDSSLGGLSRSSTVASLDTDSTKSSGQSNSNLDTCAEFRIKYVGAIEKLAVSEGKSLEGPLDLINYIDVAQQDGKLPFVPLEEEFILGVSKYGIKVSTTDQHGVLHRHALYLIIRMVCYDDGLGAGKSLLALKTTDASNEEYSLWVYQCNSLEQAQAICKVLSTAFDSVLTSDKS
uniprot
proteins
function
FUNCTION: Key regulator of the integrin-mediated cell-matrix interaction signaling by binding to the ITGB1 cytoplasmic tail and preventing the activation of integrin alpha-5/beta-1 (heterodimer of ITGA5 and ITGB1) by talin or FERMT1. Plays a role in cell proliferation, differentiation, spreading, adhesion and migration in the context of mineralization and bone development and angiogenesis. Stimulates cellular proliferation in a fibronectin-dependent manner. Involved in the regulation of beta-1 integrin-containing focal adhesion (FA) site dynamics by controlling its assembly rate during cell adhesion; inhibits beta-1 integrin clustering within FA by directly competing with talin TLN1, and hence stimulates osteoblast spreading and migration in a fibronectin- and/or collagen-dependent manner. Acts as a guanine nucleotide dissociation inhibitor (GDI) by regulating Rho family GTPases during integrin-mediated cell matrix adhesion; reduces the level of active GTP-bound form of both CDC42 and RAC1 GTPases upon cell adhesion to fibronectin. Stimulates the release of active CDC42 from the membranes to maintain it in an inactive cytoplasmic pool. Participates in the translocation of the Rho-associated protein kinase ROCK1 to membrane ruffles at cell leading edges of the cell membrane, leading to an increase of myoblast cell migration on laminin. Plays a role in bone mineralization at a late stage of osteoblast differentiation; modulates the dynamic formation of focal adhesions into fibrillar adhesions, which are adhesive structures responsible for fibronectin deposition and fibrillogenesis. Plays a role in blood vessel development; acts as a negative regulator of angiogenesis by attenuating endothelial cell proliferation and migration, lumen formation and sprouting angiogenesis by promoting AKT phosphorylation and inhibiting ERK1/2 phosphorylation through activation of the Notch signaling pathway. Promotes transcriptional activity of the MYC promoter. {ECO:0000269|PubMed:16741948, ECO:0000269|PubMed:17567669, ECO:0000269|PubMed:17654484, ECO:0000269|PubMed:18227284, ECO:0000269|PubMed:21768292}.
uniprot
proteins
mass_dalton
21644
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-38 seems to enhance integrin alpha5beta1-mediated cell adhesion. The degree of phosphorylation is regulated by integrin-dependent cell-matrix interaction (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16741948
uniprot
proteins
pubmed
17567669
uniprot
proteins
pubmed
17654484
uniprot
proteins
pubmed
18227284
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21768292
uniprot
proteins
pubmed
9626504
uniprot
proteins
sequence_length
200
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16741948}. Cell membrane {ECO:0000269|PubMed:16741948}. Cell projection, lamellipodium {ECO:0000269|PubMed:16741948}. Cell projection, ruffle {ECO:0000269|PubMed:16741948}. Note=Nucleocytoplasmic shuttling protein; shuttles between nucleus and cytoplasm in an integrin-dependent manner; probably sequestered in the cytosol by ITGB1. Its localization is dependent on the stage of cell spreading on fibronectin; cytoplasmic in case of round cells, corresponding to the initial step of cell spreading, or nuclear in case of well spread cells. Colocalizes with ROCK1 and NME2 at beta-1 integrin engagement sites. Together with ITGB1 and NME2 is recruited to beta-1 integrin-rich peripheral ruffles and lamellipodia during initial cell spreading on fibronectin and/or collagen (By similarity). {ECO:0000250}.
uniprot
proteins