TIMCC
entrez
84908
canonical
uniprot
Q96C01
canonical
ensembl
ENSG00000035141
resolver
ensp
ENSP00000037869
resolver
ensp
ENSP00000397269
resolver
enst
ENST00000037869
resolver
enst
ENST00000430566
resolver
genesymbol
TIMCC
resolver
genesymbol_syn
FAM136A
resolver
hgnc
HGNC:25911
resolver
uniprot
B0AZT6
resolver
uniprot
E7EQY1
resolver
uniprot
Q96SS3
resolver
uniprot_entry
B0AZT6_HUMAN
resolver
uniprot_entry
E7EQY1_HUMAN
resolver
uniprot_entry
TIMCC_HUMAN
resolver
uniprot_sec
Q96SS3
resolver
amino_acid_sequence
MAELQQLRVQEAVESMVKSLERENIRKMQGLMFRCSASCCEDSQASMKQVHQCIERCHVPLAQAQALVTSELEKFQDRLARCTMHCNDKAKDSIDAGSKELQVKQQLDSCVTKCVDDHMHLIPTMTKKMKEALLSIGK
uniprot
proteins
function
FUNCTION: Plays a role in proteostasis of the mitochondrion intermembrane space and counteracts aggregation of certain proteins (PubMed:40714634, PubMed:41109133). Required for mitochondrial oxidative phosphorylation (PubMed:40714634). {ECO:0000269|PubMed:40714634, ECO:0000269|PubMed:41109133}.
uniprot
proteins
mass_dalton
15641
uniprot
proteins
mutagenesis
MUTAGEN 28..32; /note="MQGLM->AQGAA,SQGSS: Impairs mitochondrial import."; /evidence="ECO:0000269|PubMed:41109133"; MUTAGEN 35; /note="C->A: Fails to localize to mitochondria and reduces protein stability; when associated with A-39, A-53 and A-57."; /evidence="ECO:0000269|PubMed:41109133"; MUTAGEN 39; /note="C->A: Fails to localize to mitochondria and reduces protein stability; when associated with A-35, A-53 and A-57."; /evidence="ECO:0000269|PubMed:41109133"; MUTAGEN 53; /note="C->A: Fails to localize to mitochondria and reduces protein stability; when associated with A-35, A-39 and A-57."; /evidence="ECO:0000269|PubMed:41109133"; MUTAGEN 57; /note="C->A: Fails to localize to mitochondria and reduces protein stability; when associated with A-35, A-39 and A-53."; /evidence="ECO:0000269|PubMed:41109133"; MUTAGEN 82; /note="C->A: Fails to localize to mitochondria and reduces protein stability; when associated with A-86, A-110 and A-114."; /evidence="ECO:0000269|PubMed:41109133"; MUTAGEN 86; /note="C->A: Fails to localize to mitochondria and reduces protein stability; when associated with A-82, A-110 and A-114."; /evidence="ECO:0000269|PubMed:41109133"; MUTAGEN 110; /note="C->A: Fails to localize to mitochondria and reduces protein stability; when associated with A-82, A-86 and A-114."; /evidence="ECO:0000269|PubMed:41109133"; MUTAGEN 114; /note="C->A: Fails to localize to mitochondria and reduces protein stability; when associated with A-82, A-86 and A-110."; /evidence="ECO:0000269|PubMed:41109133
uniprot
proteins
protein_family
TIMCC family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25305078
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
39821719
uniprot
proteins
pubmed
40714634
uniprot
proteins
pubmed
41109133
uniprot
proteins
sequence_length
138
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000269|PubMed:39821719, ECO:0000269|PubMed:40714634, ECO:0000269|PubMed:41109133}.
uniprot
proteins