Ackr5
entrez
29307
canonical
uniprot
P31392
canonical
ensembl
ENSRNOG00000004311
resolver
ensembl
ENSRNOG00055025870
resolver
ensembl
ENSRNOG00060007981
resolver
ensp
ENSRNOP00000054500
resolver
ensp
ENSRNOP00055036520
resolver
ensp
ENSRNOP00055036532
resolver
ensp
ENSRNOP00060009966
resolver
ensp
ENSRNOP00060009975
resolver
enst
ENSRNOT00055044615
resolver
enst
ENSRNOT00055044627
resolver
enst
ENSRNOT00060013145
resolver
enst
ENSRNOT00060013155
resolver
genesymbol
Ackr5
resolver
genesymbol_syn
Admr
resolver
genesymbol_syn
Gpr182
resolver
uniprot
A0A8I6AT50
resolver
uniprot
A1L1I2
resolver
uniprot
A6HQX3
resolver
uniprot
D3ZC02
resolver
uniprot
Q64166
resolver
uniprot_entry
ACKR5_RAT
resolver
uniprot_sec
A0A8I6AT50
resolver
uniprot_sec
A1L1I2
resolver
uniprot_sec
A6HQX3
resolver
uniprot_sec
D3ZC02
resolver
uniprot_sec
Q64166
resolver
amino_acid_sequence
MSVIPSSRPVSTLAPDNDFREIHNWTELLHLFNQTFSDCHMELNENTKQVVLFVFYLAIFVVGLVENVLVICVNCRRSGRVGMLNLYILNMAVADLGIILSLPVWMLEVMLEYTWLWGSFSCRFIHYFYLANMYSSIFFLTCLSIDRYVTLTNTSPSWQRHQHRIRRAVCAGVWVLSAIIPLPEVVHIQLLDGSEPMCLFLAPFETYSAWALAVALSATILGFLLPFPLIAVFNILSACRLRRQGQTESRRHCLLMWAYIAVFVICWLPYHVTMLLLTLHTTHIFLHCNLVNFLYFFYEIIDCFSMLHCVANPILYNFLSPSFRGRLLSLVVRYLPKEQARAAGGRASSSSSTQHSIIITKEGSLPAAADLHTHAIRNVQASSLPPNTSPTLCNSIAS
uniprot
proteins
function
FUNCTION: Atypical chemokine receptor that regulates chemokine levels and localization through chemokine binding, independently of activating classical ligand-induced signaling pathways such as G protein activation and Ca(2+) mobilization. Instead, it mediates chemokine sequestration, transport, or internalization to control their availability. Acts as a scavenger for a broad range of chemokines from CXC, CC and XC chemokine ligand families including CXCL9, CXCL10, CXCL12, CXCL13, CXCL11, CXCL14, CCL1, CCL11, CCL19, CCL25, CCL28 and XCL1. Is the only atypical receptor for chemokines CXCL13 and CCL28. Has a strong constitutive association with beta-arrestins, which is essential for intracellular receptor trafficking and chemokine scavenging, and occurs independently of ligand binding. Cooperates with ACKR3 and ACKR4 in regulating serum levels of CXCL12 and CCL19, respectively (By similarity). Acts as an important modulator of cellular immunity (By similarity). {ECO:0000250|UniProtKB:O15218, ECO:0000250|UniProtKB:P43142}.
uniprot
proteins
mass_dalton
45188
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7592696
uniprot
proteins
pubmed
8382168
uniprot
proteins
pubmed
8390839
uniprot
proteins
pubmed
9535752
uniprot
proteins
sequence_length
398
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O15218}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000250|UniProtKB:O15218}; Multi-pass membrane protein {ECO:0000255}. Note=Spontaneously traffic between the plasma membrane and endosomes, in a beta-arrestin-dependent manner. {ECO:0000250|UniProtKB:O15218}.
uniprot
proteins
transmembrane_region
TRANSMEM 54..75; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 87..109; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 124..145; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 167..189; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 214..235; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 255..276; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 296..316; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins