Ppm1a
entrez
24666
canonical
uniprot
P20650
canonical
ensembl
ENSRNOG00000005916
resolver
ensp
ENSRNOP00000008238
resolver
ensp
ENSRNOP00000103994
resolver
enst
ENSRNOT00000008238
resolver
genesymbol
Ppm1a
resolver
genesymbol_syn
Pp2c1
resolver
genesymbol_syn
Pppm1a
resolver
uniprot
A0A0H2UHE5
resolver
uniprot_entry
A0A0H2UHE5_RAT
resolver
uniprot_entry
PPM1A_RAT
resolver
amino_acid_sequence
MGAFLDKPKMEKHNAQGQGNGLRYGLSSMQGWRVEMEDAHTAVIGLPSGLETWSFFAVYDGHAGSQVAKYCCEHLLDHITNNQDFKGSAGAPSVENVKNGIRTGFLEIDEHMRVMSEKKHGADRSGSTAVGVLISPQHTYFINCGDSRGLLCRNRKVHFFTQDHKPSNPLEKERIQNAGGSVMIQRVNGSLAVSRALGDFDYKCVHGKGPTEQLVSPEPEVHDIERSEEDDQFIILACDGIWDVMGNEELCDFVRSRLEVTDDLEKVCNEVVDTCLYKGSRDNMSVILICFPNAPKVSAEAVKKEAELDKYLENRVEEIIKKQGEGVPDLVHVMRTLASENIPSLPPGGELASKRNVIEAVYNRLNPYKNDDTDSASTDDMW
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling (By similarity). Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
42417
uniprot
proteins
post_translational_modification
PTM: N-myristoylation is essential for the recognition of its substrates for dephosphorylation. {ECO:0000250}.
uniprot
proteins
protein_family
PP2C family
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2538815
uniprot
proteins
sequence_length
382
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P35813}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P35813}. Membrane {ECO:0000250|UniProtKB:P35813}; Lipid-anchor {ECO:0000250|UniProtKB:P35813}. Note=Weakly associates at the membrane and N-myristoylation mediates the membrane localization. {ECO:0000250|UniProtKB:P49443}.
uniprot
proteins