DHRS7B
entrez
25979
canonical
uniprot
Q6IAN0
canonical
ensembl
ENSG00000109016
resolver
ensp
ENSP00000378887
resolver
ensp
ENSP00000468585
resolver
ensp
ENSP00000551461
resolver
ensp
ENSP00000645236
resolver
ensp
ENSP00000696377
resolver
ensp
ENSP00000788308
resolver
enst
ENST00000395511
resolver
enst
ENST00000579303
resolver
genesymbol
DHRS7B
resolver
genesymbol_syn
SDR32C1
resolver
hgnc
HGNC:24547
resolver
uniprot
A0A0C4DGQ8
resolver
uniprot
B5MEF4
resolver
uniprot
Q6UX59
resolver
uniprot
Q9BTF9
resolver
uniprot
Q9UFM6
resolver
uniprot
Q9Y3A1
resolver
uniprot_entry
A0A0C4DGQ8_HUMAN
resolver
uniprot_entry
PEXRP_HUMAN
resolver
uniprot_sec
B5MEF4
resolver
uniprot_sec
Q6UX59
resolver
uniprot_sec
Q9BTF9
resolver
uniprot_sec
Q9UFM6
resolver
uniprot_sec
Q9Y3A1
resolver
amino_acid_sequence
MVSPATRKSLPKVKAMDFITSTAILPLLFGCLGVFGLFRLLQWVRGKAYLRNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKPYLVTFDLTDSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFGPVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQYEIEVTVISPGYIHTNLSVNAITADGSRYGVMDTTTAQGRSPVEVAQDVLAAVGKKKKDVILADLLPSLAVYLRTLAPGLFFSLMASRARKERKSKNS
uniprot
proteins
ec_number
1.1.1.101
uniprot
proteins
function
FUNCTION: Reductase required for adipogenesis and activation of PPARG nuclear receptor. Can convert acyl and alkyl dihydroxyacetone-phosphate (DHAP) into glycerolipids and ether lipids, respectively, synthesizing ether-linked phospholipids that act as agonists for PPARG. Also regulates adipogenesis by preventing adipocyte browning: following import into the nucleus, interacts with PRDM16, inhibiting the interaction between PRDM16 and PPARG and preventing differentiation of brown adipocytes. {ECO:0000250|UniProtKB:Q99J47}.
uniprot
proteins
mass_dalton
35119
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
10810093
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
19027726
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
325
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250|UniProtKB:Q99J47}; Single-pass type II membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q5RJY4}; Single-pass type II membrane protein {ECO:0000255}. Nucleus {ECO:0000250|UniProtKB:Q99J47}.
uniprot
proteins
transmembrane_region
TRANSMEM 18..38; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins