Fcer1g
entrez
25441
canonical
uniprot
P20411
canonical
ensembl
ENSRNOG00000024159
resolver
ensp
ENSRNOP00000102941
resolver
genesymbol
Fcer1g
resolver
genesymbol_syn
Fce1g
resolver
uniprot
B1H251
resolver
uniprot_entry
B1H251_RAT
resolver
uniprot_entry
FCERG_RAT
resolver
amino_acid_sequence
MIPAVILFLLLLVEEAAALGEPQLCYILDAILFLYGIVLTLLYCRLKIQVRKADIASREKSDAVYTGLNTRNQETYETLKHEKPPQ
uniprot
proteins
function
FUNCTION: Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. May function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation. Also involved in integrin alpha-2/ITGA2-mediated platelet activation. {ECO:0000250|UniProtKB:P20491}.
uniprot
proteins
mass_dalton
9765
uniprot
proteins
protein_family
CD3Z/FCER1G family
uniprot
proteins
pubmed
17728245
uniprot
proteins
pubmed
1825220
uniprot
proteins
pubmed
23921530
uniprot
proteins
pubmed
2521376
uniprot
proteins
sequence_length
86
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 24..44; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins