FBXL13
entrez
222235
canonical
uniprot
Q8NEE6
canonical
ensembl
ENSG00000161040
resolver
ensp
ENSP00000321927
resolver
ensp
ENSP00000390126
resolver
ensp
ENSP00000511553
resolver
ensp
ENSP00000511554
resolver
ensp
ENSP00000635748
resolver
enst
ENST00000440067
resolver
enst
ENST00000694870
resolver
enst
ENST00000694871
resolver
genesymbol
FBXL13
resolver
genesymbol_syn
DRC6
resolver
genesymbol_syn
FBL13
resolver
hgnc
HGNC:21658
resolver
uniprot
A0A8Q3WK56
resolver
uniprot
A0A8Q3WKA2
resolver
uniprot
C9J565
resolver
uniprot
C9J566
resolver
uniprot
C9JI88
resolver
uniprot
Q6UVW7
resolver
uniprot
Q6UVW8
resolver
uniprot
Q75MN5
resolver
uniprot
Q86UJ5
resolver
uniprot
Q8N1P0
resolver
uniprot
Q8N7Y4
resolver
uniprot
Q8TCL2
resolver
uniprot
Q8WUF9
resolver
uniprot
Q8WUG0
resolver
uniprot_entry
A0A8Q3WK56_HUMAN
resolver
uniprot_entry
A0A8Q3WKA2_HUMAN
resolver
uniprot_entry
C9JI88_HUMAN
resolver
uniprot_entry
FXL13_HUMAN
resolver
uniprot_entry
Q8N1P0_HUMAN
resolver
uniprot_sec
C9J565
resolver
uniprot_sec
C9J566
resolver
uniprot_sec
Q6UVW7
resolver
uniprot_sec
Q6UVW8
resolver
uniprot_sec
Q75MN5
resolver
uniprot_sec
Q86UJ5
resolver
uniprot_sec
Q8N7Y4
resolver
uniprot_sec
Q8TCL2
resolver
uniprot_sec
Q8WUF9
resolver
uniprot_sec
Q8WUG0
resolver
amino_acid_sequence
MTPELMIKACSFYTGHLVKTHFCTWRDIARTNENVVLAEKMNRAVTCYNFRLQKSVFHHWHSYMEDQKEKLKNILLRIQQIIYCHKLTIILTKWRNTARHKSKKKEDELILKHELQLKKWKNRLILKRAAAEESNFPERSSSEVFLVDETLKCDISLLPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQRWRLNVLRLNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDESMRHISEGCPGVLCLNLSNTTITNRTMRLLPRHFHNLQNLSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLSPLKQLTVLNLANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGYIVNIFSLVSIDLSGTDISNEGLNVLSRHKKLKELSVSECYRITDDGIQAFCKSSLILEHLDVSYCSQLSDMIIKALAIYCINLTSLSIAGCPKITDSAMEMLSAKCHYLHILDISGCVLLTDQILEDLQIGCKQLRILKMQYCTNISKKAAQRMSSKVQQQEYNTNDPPRWFGYDREGNPVTELDNITSSKGALELTVKKSTYSSEDQAA
uniprot
proteins
function
FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Specifically targets CEP192 isoform 3 for ubiquitin-mediated proteolysis and thereby acts as a regulator of microtubule nucleation activity (PubMed:29348145). {ECO:0000250|UniProtKB:A8JHD7, ECO:0000269|PubMed:29348145}.
uniprot
proteins
mass_dalton
83924
uniprot
proteins
protein_family
DRC6 family
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15820312
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
29348145
uniprot
proteins
sequence_length
735
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:A8JHD7}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:29348145}.
uniprot
proteins