CNOT11
entrez
55571
canonical
uniprot
Q9UKZ1
canonical
ensembl
ENSG00000158435
resolver
ensp
ENSP00000289382
resolver
enst
ENST00000289382
resolver
genesymbol
CNOT11
resolver
genesymbol_syn
C2orf29
resolver
hgnc
HGNC:25217
resolver
uniprot
Q6P2M9
resolver
uniprot
Q8N681
resolver
uniprot_entry
CNO11_HUMAN
resolver
uniprot_sec
Q6P2M9
resolver
uniprot_sec
Q8N681
resolver
amino_acid_sequence
MPGGGASAASGRLLTAAEQRGSREAAGSASRSGFGGSGGGRGGASGPGSGSGGPGGPAGRMSLTPKELSSLLSIISEEAGGGSTFEGLSTAFHHYFSKADHFRLGSVLVMLLQQPDLLPSAAQRLTALYLLWEMYRTEPLAANPFAASFAHLLNPAPPARGGQEPDRPPLSGFLPPITPPEKFFLSQLMLAPPRELFKKTPRQIALMDVGNMGQSVDISGLQLALAERQSELPTQSKASFPSILSDPDPDSSNSGFDSSVASQITEALVSGPKPPIESHFRPEFIRPPPPLHICEDELAWLNPTEPDHAIQWDKSMCVKNSTGVEIKRIMAKAFKSPLSSPQQTQLLGELEKDPKLVYHIGLTPAKLPDLVENNPLVAIEMLLKLMQSSQITEYFSVLVNMDMSLHSMEVVNRLTTAVDLPPEFIHLYISNCISTCEQIKDKYMQNRLVRLVCVFLQSLIRNKIINVQDLFIEVQAFCIEFSRIREAAGLFRLLKTLDTGETPSETKMSK
uniprot
proteins
function
FUNCTION: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is required for the association of CNOT10 with the CCR4-NOT complex. Does not seem to be required for complex deadenylase function.
uniprot
proteins
mass_dalton
55215
uniprot
proteins
protein_family
CNOT11 family
uniprot
proteins
pubmed
10497265
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
19558367
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23232451
uniprot
proteins
pubmed
23303381
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
510
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
uniprot
proteins