SLC9A4
entrez
389015
canonical
uniprot
Q6AI14
canonical
ensembl
ENSG00000180251
resolver
ensp
ENSP00000295269
resolver
enst
ENST00000295269
resolver
genesymbol
SLC9A4
resolver
genesymbol_syn
NHE4
resolver
hgnc
HGNC:11077
resolver
uniprot
Q69YK0
resolver
uniprot_entry
SL9A4_HUMAN
resolver
uniprot_sec
Q69YK0
resolver
amino_acid_sequence
MALQMFVTYSPWNCLLLLVALECSEASSDLNESANSTAQYASNAWFAAASSEPEEGISVFELDYDYVQIPYEVTLWILLASLAKIGFHLYHRLPGLMPESCLLILVGALVGGIIFGTDHKSPPVMDSSIYFLYLLPPIVLEGGYFMPTRPFFENIGSILWWAVLGALINALGIGLSLYLICQVKAFGLGDVNLLQNLLFGSLISAVDPVAVLAVFEEARVNEQLYMMIFGEALLNDGITVVLYNMLIAFTKMHKFEDIETVDILAGCARFIVVGLGGVLFGIVFGFISAFITRFTQNISAIEPLIVFMFSYLSYLAAETLYLSGILAITACAVTMKKYVEENVSQTSYTTIKYFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFICFTLAFCQIWRAISVFALFYISNQFRTFPFSIKDQCIIFYSGVRGAGSFSLAFLLPLSLFPRKKMFVTATLVVIYFTVFIQGITVGPLVRYLDVKKTNKKESINEELHIRLMDHLKAGIEDVCGHWSHYQVRDKFKKFDHRYLRKILIRKNLPKSSIVSLYKKLEMKQAIEMVETGILSSTAFSIPHQAQRIQGIKRLSPEDVESIRDILTSNMYQVRQRTLSYNKYNLKPQTSEKQAKEILIRRQNTLRESMRKGHSLPWGKPAGTKNIRYLSYPYGNPQSAGRDTRAAGFSDDDSSDPGSPSITFSACSRIGSLQKQEAQEIIPMKSLHRGRKAFSFGYQRNTSQEEYLGGVRRVALRPKPLFHAVDEEGESGGESEGKASLVEVRSRWTADHGHGRDHHRSHSPLLQKK
uniprot
proteins
function
FUNCTION: Electroneutral antiporter that exchanges sodium for protons or ammonium ions at the basolateral membrane of epithelia to regulate cell volume and intracellular pH upon hypertonic conditions (By similarity). As part of transcellular ammonia transport in renal tubules, mediates basolateral ammonium extrusion in the medullary thick ascending limb, regulating the corticopapillary ammonium gradient and overall renal acid excretion (By similarity). Mediates sodium:proton exchange in gastric parietal cells secondary to cAMP-dependent acid secretion and hyperosmolarity. Possibly coupled to chloride:bicarbonate antiporter, enables loading of parietal cells with sodium and chloride ions to maintain cell volume and normal gastric acid secretion (By similarity). Functions as a sodium sensor in neurons of organum vasculosum of the lamina terminalis where it regulates water intake in response to increased sodium concentration in body fluids (By similarity). {ECO:0000250|UniProtKB:P26434, ECO:0000250|UniProtKB:Q8BUE1}.
uniprot
proteins
mass_dalton
89814
uniprot
proteins
post_translational_modification
PTM: May be phosphorylated. {ECO:0000250}.
uniprot
proteins
protein_family
Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17974005
uniprot
proteins
sequence_length
798
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000250|UniProtKB:P26434}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q8BUE1}; Multi-pass membrane protein {ECO:0000255}. Zymogen granule membrane {ECO:0000250|UniProtKB:P26434}; Multi-pass membrane protein {ECO:0000255}. Note=Enrichment at apical or basolateral membrane may be tissue-dependent. {ECO:0000250|UniProtKB:P26434}.
uniprot
proteins
transmembrane_region
TRANSMEM 95..115; /note="Helical; Name=C/M3"; /evidence="ECO:0000255"; TRANSMEM 128..148; /note="Helical; Name=D/M4"; /evidence="ECO:0000255"; TRANSMEM 155..175; /note="Helical; Name=E/M5"; /evidence="ECO:0000255"; TRANSMEM 197..217; /note="Helical; Name=F/M5A"; /evidence="ECO:0000255"; TRANSMEM 227..247; /note="Helical; Name=G/M5B"; /evidence="ECO:0000255"; TRANSMEM 271..291; /note="Helical; Name=H/M6"; /evidence="ECO:0000255"; TRANSMEM 305..325; /note="Helical; Name=I/M7"; /evidence="ECO:0000255"; TRANSMEM 357..373; /note="Helical; Name=J/M8"; /evidence="ECO:0000255"; TRANSMEM 385..405; /note="Helical; Name=K/M9"; /evidence="ECO:0000255"; TRANSMEM 451..471; /note="Helical; Name=M/M10"; /evidence="ECO:0000255
uniprot
proteins