Slco2a1
entrez
24059
canonical
uniprot
Q9EPT5
canonical
ensembl
ENSMUSG00000032548
resolver
ensp
ENSMUSP00000035148
resolver
genesymbol
Slco2a1
resolver
genesymbol_syn
Oatp2a1
resolver
genesymbol_syn
Slc21a2
resolver
uniprot
Q3TED0
resolver
uniprot_entry
Q3TED0_MOUSE
resolver
uniprot_entry
SO2A1_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Higher dietary salt intake stimulates transcription (PubMed:18579702). Chorionic gonadotropin stimulates expression in the ovaries (PubMed:27169804). {ECO:0000269|PubMed:18579702, ECO:0000269|PubMed:27169804}.
uniprot
proteins
amino_acid_sequence
MGLLPKPGARQGSGTSSVPARRCSRSVFNNIKVFVLCHGLLQLCQLLYSAYFKSSLTTIEKRFGLSSSSSGLISSLNEISNAILIIFVSYFGSRVNRPRMIGIGGLLLAAGAFVLTLPHFLSEPYQYASTTAGNSSHFQTDLCQKHLPGLLPSKCHSTVPDTQKETSSMWSLMVVAQLLAGVGTVPIQPFGISYVDDFAEPTNSPLYISILFAIAVFGPAFGYLLGSVMLRIFVDYGRVDTATVNLSPGDPRWIGAWWLGLLISSGFLIVTSLPFFFFPRAMSRGAERSVIAEETMKMEEDKSRGSLMDFIKRFPRIFLRLLMNPLFMLVVLSQCTFSSVIAGLSTFLNKFLEKQYDASAAYANLLIGAVNLPAAALGMLFGGILMKRFVFPLQTIPRVAATIMTISIILCAPLFFMGCSTPAVAEVYPPSTPSSIHPQPPACRRDCLCPDSVFHPVCGDNGVEYLSPCHAGCSSLNVSSAASKQPIYLNCSCVTGGSASAKTGSCPTSCAQLLLPSIFLISFVALIACVSHNPLYMMVLRVVNQDEKSFAIGVQFLLMRLLAWLPSPSLYGLLIDSSCIRWNYLCSGRRGACAYYDNDALRNRYLGLQVIYKVLGTLLLFFISWRVKKNREYSLQENASGLI
uniprot
proteins
function
FUNCTION: Mediates the transport of prostaglandins (PGs, mainly PGE2, PGE1, PGE3, PGF2alpha, PGD2, PGH2) and thromboxanes (thromboxane B2) across the cell membrane (Probable) (PubMed:10484490). PGs and thromboxanes play fundamental roles in diverse functions such as intraocular pressure, gastric acid secretion, renal salt and water transport, vascular tone, and fever (By similarity). Plays a role in the clearance of PGs from the circulation through cellular uptake, which allows cytoplasmic oxidation and PG signal termination (Probable) (PubMed:10484490). PG uptake is dependent upon membrane potential and involves exchange of a monovalent anionic substrate (PGs exist physiologically as an anionic monovalent form) with a stoichiometry of 1:1 for divalent anions or of 1:2 for monovalent anions (By similarity). Uses lactate, generated by glycolysis, as a counter-substrate to mediate PG influx and efflux. Under nonglycolytic conditions, metabolites other than lactate might serve as counter-substrates. Although the mechanism is not clear, this transporter can function in bidirectional mode (By similarity). When apically expressed in epithelial cells, it facilitates transcellular transport (also called vectorial release), extracting PG from the apical medium and facilitating transport across the cell toward the basolateral side, whereupon the PG exits the cell by simple diffusion (PubMed:18579702). In the renal collecting duct, regulates renal Na+ balance by removing PGE2 from apical medium (PGE2 EP4 receptor is likely localized to the luminal/apical membrane and stimulates Na+ resorption) and transporting it toward the basolateral membrane (where PGE2 EP1 and EP3 receptors inhibit Na+ resorption) (PubMed:18579702). Plays a role in endometrium during decidualization, increasing uptake of PGs by decidual cells (By similarity). Involved in critical events for ovulation (PubMed:27169804). Regulates extracellular PGE2 concentration for follicular development in the ovaries (PubMed:27169804). When expressed intracellularly, such as in macrophages, contributes to vesicular uptake of newly synthesized intracellular PGs, thereby facilitating exocytotic secretion of PGs without being metabolized (PubMed:26474801). Essential core component of the major type of large-conductance anion channel, Maxi-Cl, which plays essential roles in inorganic anion transport, cell volume regulation and release of ATP and glutamate not only in physiological processes but also in pathological processes (PubMed:29046334, PubMed:32442363). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (By similarity). {ECO:0000250|UniProtKB:Q92959, ECO:0000269|PubMed:10484490, ECO:0000269|PubMed:18579702, ECO:0000269|PubMed:26474801, ECO:0000269|PubMed:27169804, ECO:0000269|PubMed:29046334, ECO:0000269|PubMed:32442363, ECO:0000305|PubMed:26692285}.
uniprot
proteins
mass_dalton
70147
uniprot
proteins
mutagenesis
MUTAGEN 610; /note="V->M: No effect."; /evidence="ECO:0000269|PubMed:10484490"; MUTAGEN 611; /note="I->G: No effect."; /evidence="ECO:0000269|PubMed:10484490
uniprot
proteins
protein_family
Organo anion transporter (TC 2.A.60) family
uniprot
proteins
pubmed
10484490
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18579702
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26474801
uniprot
proteins
pubmed
26692285
uniprot
proteins
pubmed
27169804
uniprot
proteins
pubmed
29046334
uniprot
proteins
pubmed
32442363
uniprot
proteins
sequence_length
643
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q92959}; Multi-pass membrane protein {ECO:0000255}. Basal cell membrane {ECO:0000250|UniProtKB:Q92959}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:26474801}. Lysosome {ECO:0000269|PubMed:26474801}.
uniprot
proteins
transmembrane_region
TRANSMEM 33..52; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 72..92; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 99..123; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 168..196; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 216..236; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 255..279; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 321..342; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 363..386; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 391..414; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 518..540; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 550..575; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 610..628; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins