Fmo3
entrez
84493
canonical
uniprot
Q9EQ76
canonical
ensembl
ENSRNOG00000003620
resolver
ensp
ENSRNOP00000004864
resolver
enst
ENSRNOT00000004864
resolver
genesymbol
Fmo3
resolver
uniprot
A0A0G2JSI0
resolver
uniprot
Q5PQV6
resolver
uniprot_entry
A0A0G2JSI0_RAT
resolver
uniprot_entry
FMO3_RAT
resolver
uniprot_sec
Q5PQV6
resolver
amino_acid_sequence
MKRKVAVIGAGVSGLAAIRSCLEEGLEPTCFERSDDVGGLWKFSDHTEEGRASIYQSVFTNSSKEMMCFPDFPYPDDFPNFMHNSKLQEYITSFATEKNLLKYIQFETLVTRINKCPDFSTTGKWEVTTEKNSKKETAVFDAVMICSGHHVYPHLPKDSFPGLNRFKGKCFHSRDYKEPGTWKGKRVLVIGLGNSGCDIAAELSHVAQQVIISSRSGSWVMSRVWNDGYPWDMVVITRFQTFLKNNLPTAISDWWYMKQMNARFKHENYGLMPLNGTLRKEPVFNDELPARILCGTVSIKPNVKEFTETSAVFEDGTVFEGIDCVIFATGYGYAYPFLDDSIIKSRNNEVTLYKGIFPPQLEKPTMAVIGLVQSLGAAIPTTDLQARWAAQVIRGTCILPSVNDMMDDIDEKMGKKLKWFGNSTTIQTDYIVYMDELASFIGAKPNILWLFLKDPRLAIEVFFGPCSPYQFRLVGPGKWSGARNAILTQWDRSLKPMKTRVVGGIQKPCLYSHFLRLLAVPVLIALFLVLI
uniprot
proteins
ec_number
1.14.13.148
uniprot
proteins
ec_number
1.14.13.32
uniprot
proteins
ec_number
1.14.13.8
uniprot
proteins
function
FUNCTION: Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds (PubMed:3739217, PubMed:7736906). Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation. {ECO:0000250|UniProtKB:P31513, ECO:0000269|PubMed:3739217, ECO:0000269|PubMed:7736906}.
uniprot
proteins
mass_dalton
59960
uniprot
proteins
protein_family
FMO family
uniprot
proteins
pubmed
11414682
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19307449
uniprot
proteins
pubmed
3739217
uniprot
proteins
pubmed
7736906
uniprot
proteins
sequence_length
531
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000269|PubMed:19307449}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P32417}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 511..531; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins