Htr1b
entrez
25075
canonical
uniprot
P28564
canonical
ensembl
ENSRNOG00000013042
resolver
ensembl
ENSRNOG00055004785
resolver
ensp
ENSRNOP00000017411
resolver
ensp
ENSRNOP00000103273
resolver
ensp
ENSRNOP00000105377
resolver
ensp
ENSRNOP00000112035
resolver
ensp
ENSRNOP00055005736
resolver
ensp
ENSRNOP00055005738
resolver
enst
ENSRNOT00000017411
resolver
enst
ENSRNOT00000123084
resolver
enst
ENSRNOT00000145729
resolver
enst
ENSRNOT00000146843
resolver
enst
ENSRNOT00055007617
resolver
enst
ENSRNOT00055007619
resolver
genesymbol
Htr1b
resolver
genesymbol_syn
5ht1b
resolver
uniprot_entry
5HT1B_RAT
resolver
amino_acid_sequence
MEEQGIQCAPPPPATSQTGVPLANLSHNCSADDYIYQDSIALPWKVLLVALLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASIMHLCVIALDRYWAITDAVDYSAKRTPKRAAIMIVLVWVFSISISLPPFFWRQAKAEEEVLDCFVNTDHVLYTVYSTVGAFYLPTLLLIALYGRIYVEARSRILKQTPNKTGKRLTRAQLITDSPGSTSSVTSINSRVPEVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHMAIFDFFNWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTG
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1836757, Ref.1). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD) (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). HTR1B is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (By similarity). Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (By similarity). Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior (By similarity). Besides, plays a role in vasoconstriction of cerebral arteries (By similarity). {ECO:0000250|UniProtKB:P28222, ECO:0000269|PubMed:1836757, ECO:0000269|Ref.1}.
uniprot
proteins
mass_dalton
43163
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Desensitization of the receptor may be mediated by its phosphorylation. {ECO:0000250|UniProtKB:P28222}.; PTM: Palmitoylated. {ECO:0000250|UniProtKB:P28222}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
1836757
uniprot
proteins
sequence_length
386
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1836757, ECO:0000269|Ref.1}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 43..68; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P28222"; TRANSMEM 83..107; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P28222"; TRANSMEM 116..141; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P28222"; TRANSMEM 162..180; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P28222"; TRANSMEM 202..225; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P28222"; TRANSMEM 312..333; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P28222"; TRANSMEM 344..366; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P28222
uniprot
proteins