Cyp7a1
entrez
25428
canonical
uniprot
P18125
canonical
ensembl
ENSRNOG00000009488
resolver
ensembl
ENSRNOG00055020237
resolver
ensembl
ENSRNOG00060016388
resolver
ensembl
ENSRNOG00065015630
resolver
ensp
ENSRNOP00000012819
resolver
ensp
ENSRNOP00055028005
resolver
ensp
ENSRNOP00060022609
resolver
ensp
ENSRNOP00065020449
resolver
enst
ENSRNOT00000012819
resolver
enst
ENSRNOT00055034564
resolver
enst
ENSRNOT00060028089
resolver
enst
ENSRNOT00065025975
resolver
genesymbol
Cyp7a1
resolver
genesymbol_syn
Cyp7
resolver
uniprot
P51543
resolver
uniprot_entry
CP7A1_RAT
resolver
uniprot_sec
P51543
resolver
amino_acid_sequence
MMTISLIWGIAVLVSCCIWFIVGIRRRKAGEPPLENGLIPYLGCALKFGSNPLEFLRANQRKHGHVFTCKLMGKYVHFITNSLSYHKVLCHGKYFDWKKFHYTTSAKAFGHRSIDPNDGNTTENINNTFTKTLQGDALCSLSEAMMQNLQSVMRPPGLPKSKSNAWVTEGMYAFCYRVMFEAGYLTLFGRDISKTDTQKALILNNLDNFKQFDQVFPALVAGLPIHLFKTAHKAREKLAEGLKHKNLCVRDQVSELIRLRMFLNDTLSTFDDMEKAKTHLAILWASQANTIPATFWSLFQMIRSPEAMKAASEEVSGALQSAGQELSSGGSAIYLDQVQLNDLPVLDSIIKEALRLSSASLNIRTAKEDFTLHLEDGSYNIRKDDMIALYPQLMHLDPEIYPDPLTFKYDRYLDESGKAKTTFYSNGNKLKCFYMPFGSGATICPGRLFAVQEIKQFLILMLSCFELEFVESQVKCPPLDQSRAGLGILPPLHDIEFKYKLKH
uniprot
proteins
ec_number
1.14.14.23
uniprot
proteins
ec_number
1.14.14.26
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols) (PubMed:1694852, PubMed:2335522). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:1694852, PubMed:2335522). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting step in cholesterol catabolism and bile acid biosynthesis (PubMed:1694852, PubMed:2335522). 7-alpha hydroxylates several oxysterols, including 4beta-hydroxycholesterol and 24-hydroxycholesterol. Catalyzes the oxidation of the 7,8 double bond of 7-dehydrocholesterol and lathosterol with direct and predominant formation of the 7-keto derivatives (By similarity). {ECO:0000250|UniProtKB:P22680, ECO:0000269|PubMed:1694852, ECO:0000269|PubMed:2335522}.
uniprot
proteins
mass_dalton
56883
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; bile acid biosynthesis. {ECO:0000305|PubMed:1694852, ECO:0000305|PubMed:2335522}.; PATHWAY: Steroid metabolism; cholesterol degradation. {ECO:0000305|PubMed:1694852, ECO:0000305|PubMed:2335522}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
11278771
uniprot
proteins
pubmed
1420318
uniprot
proteins
pubmed
1693613
uniprot
proteins
pubmed
1694852
uniprot
proteins
pubmed
2007596
uniprot
proteins
pubmed
2261433
uniprot
proteins
pubmed
2335522
uniprot
proteins
pubmed
2806567
uniprot
proteins
pubmed
8021257
uniprot
proteins
sequence_length
503
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:1694852}; Single-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000305|PubMed:1694852}; Single-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins