Hsd17b8
entrez
361802
canonical
uniprot
Q6MGB5
canonical
ensembl
ENSRNOG00000000466
resolver
ensembl
ENSRNOG00065000595
resolver
ensp
ENSRNOP00000073887
resolver
ensp
ENSRNOP00000098200
resolver
ensp
ENSRNOP00000101602
resolver
ensp
ENSRNOP00065000680
resolver
enst
ENSRNOT00000081486
resolver
enst
ENSRNOT00000120559
resolver
enst
ENSRNOT00000131886
resolver
enst
ENSRNOT00065000844
resolver
genesymbol
Hsd17b8
resolver
uniprot
A0A0G2K6P1
resolver
uniprot
A0ABK0L0T9
resolver
uniprot_entry
A0A0G2K6P1_RAT
resolver
uniprot_entry
A0ABK0L0T9_RAT
resolver
uniprot_entry
DHB8_RAT
resolver
amino_acid_sequence
MASQLRLRSALALVTGAGSGIGRAISVRLAAEGAAVAACDLDGAAAQDTVRLLGNPGSEDREPRGKHAAFQADVSEGPAAKRLLEQVQACFFRPPSVVVSCAGITRDEFLLHMSEEDWDRVIAVNLKGTFLVTQAAAQALVSSGGRGSIINISSIVGKVGNIGQTNYASSKAGVIGLTQTAARELGRHGIRCNSVLPGFIATPMTQKMPEKVKDKVTAMIPLGHMGDPEDVADVVAFLASEDSGYITGASVEVSGGLFM
uniprot
proteins
ec_number
1.1.1.239
uniprot
proteins
ec_number
1.1.1.62
uniprot
proteins
ec_number
1.1.1.n12
uniprot
proteins
function
FUNCTION: Required for the solubility and assembly of the heterotetramer 3-ketoacyl-[acyl carrier protein] (ACP) reductase functional complex (KAR or KAR1) that forms part of the mitochondrial fatty acid synthase (mtFAS). Alpha-subunit of the KAR complex that acts as scaffold protein required for the stability of carbonyl reductase type-4 (CBR4, beta-subunit of the KAR complex) and for its 3-ketoacyl-ACP reductase activity, thereby participating in mitochondrial fatty acid biosynthesis. Catalyzes the NAD-dependent conversion of (3R)-3-hydroxyacyl-CoA into 3-ketoacyl-CoA (3-oxoacyl-CoA) with no chain length preference; this enzymatic activity is not needed for the KAR function. Prefers (3R)-3-hydroxyacyl-CoA over (3S)-3-hydroxyacyl-CoA and displays enzymatic activity only in the presence of NAD(+). Cooperates with enoyl-CoA hydratase 1 in mitochondria, together they constitute an alternative route to the auxiliary enzyme pathways for the breakdown of Z-PUFA (cis polyunsaturated fatty acid) enoyl-esters. NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol (17beta-estradiol or E2). Has very low activity towards testosterone and dihydrotestosterone (17beta-hydroxy-5alpha-androstan-3-one). Primarily an oxidative enzyme, it can switch to a reductive mode determined in the appropriate physiologic milieu and catalyze the reduction of estrone (E1) to form biologically active 17beta-estradiol. {ECO:0000250|UniProtKB:Q92506}.
uniprot
proteins
mass_dalton
26791
uniprot
proteins
pathway_participation
PATHWAY: Steroid biosynthesis; estrogen biosynthesis. {ECO:0000250|UniProtKB:Q92506}.; PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000250|UniProtKB:Q92506}.; PATHWAY: Lipid metabolism; mitochondrial fatty acid beta-oxidation. {ECO:0000250|UniProtKB:Q92506}.
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
15060004
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9712896
uniprot
proteins
sequence_length
259
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:Q92506}.
uniprot
proteins