SDHAF3
entrez
57001
canonical
uniprot
Q9NRP4
canonical
ensembl
ENSG00000196636
resolver
ensp
ENSP00000414066
resolver
enst
ENST00000432641
resolver
genesymbol
SDHAF3
resolver
genesymbol_syn
ACN9
resolver
hgnc
HGNC:21752
resolver
uniprot
A4D1J3
resolver
uniprot
Q75MD6
resolver
uniprot_entry
SDHF3_HUMAN
resolver
uniprot_sec
A4D1J3
resolver
uniprot_sec
Q75MD6
resolver
amino_acid_sequence
MPGRHVSRVRALYKRVLQLHRVLPPDLKSLGDQYVKDEFRRHKTVGSDEAQRFLQEWEVYATALLQQANENRQNSTGKACFGTFLPEEKLNDFRDEQIGQLQELMQEATKPNRQFSISESMKPKF
uniprot
proteins
function
FUNCTION: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit SDHB of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1. {ECO:0000250|UniProtKB:Q04401, ECO:0000250|UniProtKB:Q8SZ16}.
uniprot
proteins
mass_dalton
14652
uniprot
proteins
protein_family
Complex I LYR family
uniprot
proteins
protein_family
SDHAF3 subfamily
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
125
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:Q04401}.
uniprot
proteins