IFNLR1
entrez
163702
canonical
uniprot
Q8IU57
canonical
ensembl
ENSG00000185436
resolver
ensp
ENSP00000327824
resolver
ensp
ENSP00000328994
resolver
ensp
ENSP00000363542
resolver
genesymbol
IFNLR1
resolver
genesymbol_syn
IL28RA
resolver
genesymbol_syn
LICR2
resolver
hgnc
HGNC:18584
resolver
uniprot
Q5VTX5
resolver
uniprot
Q5VTX7
resolver
uniprot
Q5VTX8
resolver
uniprot
Q6ZML8
resolver
uniprot
Q8IV66
resolver
uniprot
Q8IZI7
resolver
uniprot
Q8IZI8
resolver
uniprot_entry
INLR1_HUMAN
resolver
uniprot_sec
Q5VTX5
resolver
uniprot_sec
Q5VTX7
resolver
uniprot_sec
Q5VTX8
resolver
uniprot_sec
Q6ZML8
resolver
uniprot_sec
Q8IV66
resolver
uniprot_sec
Q8IZI7
resolver
uniprot_sec
Q8IZI8
resolver
amino_acid_sequence
MAGPERWGPLLLCLLQAAPGRPRLAPPQNVTLLSQNFSVYLTWLPGLGNPQDVTYFVAYQSSPTRRRWREVEECAGTKELLCSMMCLKKQDLYNKFKGRVRTVSPSSKSPWVESEYLDYLFEVEPAPPVLVLTQTEEILSANATYQLPPCMPPLDLKYEVAFWKEGAGNKTLFPVTPHGQPVQITLQPAASEHHCLSARTIYTFSVPKYSKFSKPTCFLLEVPEANWAFLVLPSLLILLLVIAAGGVIWKTLMGNPWFQRAKMPRALDFSGHTHPVATFQPSRPESVNDLFLCPQKELTRGVRPTPRVRAPATQQTRWKKDLAEDEEEEDEEDTEDGVSFQPYIEPPSFLGQEHQAPGHSEAGGVDSGRPRAPLVPSEGSSAWDSSDRSWASTVDSSWDRAGSSGYLAEKGPGQGPGGDGHQESLPPPEFSKDSGFLEELPEDNLSSWATWGTLPPEPNLVPGGPPVSLQTLTFCWESSPEEEEEARESEIEDSDAGSWGAESTQRTEDRGRTLGHYMAR
uniprot
proteins
function
FUNCTION: The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. {ECO:0000269|PubMed:12469119, ECO:0000269|PubMed:12483210, ECO:0000269|PubMed:12521379}.
uniprot
proteins
mass_dalton
57653
uniprot
proteins
mutagenesis
MUTAGEN 319; /note="K->R: More resistant to viral-induced degradation; when associated with R-320."; /evidence="ECO:0000269|PubMed:36379255"; MUTAGEN 320; /note="K->R: More resistant to viral-induced degradation; when associated with R-319."; /evidence="ECO:0000269|PubMed:36379255
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by FBXO45-containing E3 ligase leading to proteasomal degradation. {ECO:0000269|PubMed:36379255}.
uniprot
proteins
protein_family
Type II cytokine receptor family
uniprot
proteins
pubmed
12469119
uniprot
proteins
pubmed
12483210
uniprot
proteins
pubmed
12521379
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
20934432
uniprot
proteins
pubmed
36379255
uniprot
proteins
sequence_length
520
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 229..249; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins