Klre1
entrez
297645
canonical
uniprot
Q80ZC8
canonical
ensembl
ENSRNOG00000058714
resolver
ensp
ENSRNOP00000074069
resolver
genesymbol
Klre1
resolver
uniprot
Q80ST4
resolver
uniprot_entry
KLRE1_RAT
resolver
uniprot_sec
Q80ST4
resolver
amino_acid_sequence
MNQTLIICSTLNVNSQQKSKAKNSMKNTFHSNELSSIEQRQKYQKHLKKDKKTAEDITGVGNCSPPWRLISSVLFVVCLLLMAVAMVMTIFTTRLSSERSSSNIHQEGLHHPCPENWVWFRCSCYYFSKEKLVWRESQRACLSFNSSLIRMNKEEMDFFSLKSFFWVGVYYDETSKQWLWDDHSVLPSGMFSGLESSPKNFCASYKSKEAYLAENCSTKLMYICKK
uniprot
proteins
function
FUNCTION: Lectin-like receptor for natural killer (NK) cells (PubMed:12782717, PubMed:18713988). Can either inhibit or activate NK cell cytotoxic activity, depending on its binding partner (PubMed:18713988). Heterodimer formation with KLRI1 mediates NK cell inhibition whereas heterodimer formation with KLRI2 mediates NK cell activation (PubMed:18713988). Plays a role in allogeneic recognition by the immune system (By similarity). {ECO:0000250|UniProtKB:Q8CJC7, ECO:0000269|PubMed:18713988}.
uniprot
proteins
mass_dalton
26266
uniprot
proteins
pubmed
12782717
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
18713988
uniprot
proteins
sequence_length
226
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12782717, ECO:0000269|PubMed:18713988}; Single-pass type II membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 73..93; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins