Prox1
entrez
19130
canonical
uniprot
P48437
canonical
ensembl
ENSMUSG00000010175
resolver
ensp
ENSMUSP00000010319
resolver
ensp
ENSMUSP00000135066
resolver
ensp
ENSMUSP00000135703
resolver
ensp
ENSMUSP00000182407
resolver
ensp
ENSMUSP00000182409
resolver
ensp
ENSMUSP00000182410
resolver
enst
ENSMUST00000010319
resolver
enst
ENSMUST00000175916
resolver
enst
ENSMUST00000177288
resolver
genesymbol
Prox1
resolver
uniprot
O88478
resolver
uniprot
Q3UPV1
resolver
uniprot
Q543D8
resolver
uniprot_entry
PROX1_MOUSE
resolver
uniprot_sec
O88478
resolver
uniprot_sec
Q3UPV1
resolver
uniprot_sec
Q543D8
resolver
amino_acid_sequence
MPDHDSTALLSRQTKRRRVDIGVKRTVGTASAFFAKARATFFSAMNPQGSEQDVEYSVVQHADGEKSNVLRKLLKRANSYEDAMMPFPGATIISQLLKNNMNKNGGTEPSFQASGLSSTGSEVHQEDICSNSSRDSPPECLSPFGRPTMSQFDVDRLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQKQLRQLQEKFYQVYDSTDSENDEDGDLSEDSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGSNKERDHGPNSLQPEGKHLAETLKQELNTAMSQVVDTVVKVFSAKPSRQVPQVFPPLQIPQARFAVNGENHNFHTANQRLQCFGDVIIPNPLDTFGSVQMPSSTDQTEALPLVVRKNSSEQSASGPATGGHHQPLHQSPLSATAGFTTPSFRHPFPLPLMAYPFQSPLGAPSGSFSGKDRASPESLDLTRDTTSLRTKMSSHHLSHHPCSPAHPPSTAEGLSLSLIKSECGDLQDMSDISPYSGSAMQEGLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRDCELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQELLHE
uniprot
proteins
function
FUNCTION: Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. {ECO:0000269|PubMed:23723244, ECO:0000303|PubMed:22733308}.
uniprot
proteins
mass_dalton
83126
uniprot
proteins
protein_family
Prospero homeodomain family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22733308
uniprot
proteins
pubmed
23723244
uniprot
proteins
pubmed
28179430
uniprot
proteins
pubmed
7908825
uniprot
proteins
pubmed
9703987
uniprot
proteins
sequence_length
737
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23723244}. Note=RORG promotes its nuclear localization. {ECO:0000269|PubMed:23723244}.
uniprot
proteins