ORAI2
entrez
80228
canonical
uniprot
Q96SN7
canonical
ensembl
ENSG00000160991
resolver
ensp
ENSP00000348752
resolver
ensp
ENSP00000385489
resolver
ensp
ENSP00000417928
resolver
ensp
ENSP00000418140
resolver
ensp
ENSP00000418464
resolver
ensp
ENSP00000420178
resolver
ensp
ENSP00000478113
resolver
enst
ENST00000356387
resolver
enst
ENST00000403646
resolver
enst
ENST00000473939
resolver
enst
ENST00000478730
resolver
enst
ENST00000495936
resolver
enst
ENST00000498661
resolver
enst
ENST00000611770
resolver
genesymbol
ORAI2
resolver
genesymbol_syn
C7orf19
resolver
genesymbol_syn
CBCIP2
resolver
genesymbol_syn
TMEM142B
resolver
hgnc
HGNC:21667
resolver
uniprot
B4DUB4
resolver
uniprot
Q6IA68
resolver
uniprot
Q8WY94
resolver
uniprot
Q9H9Y3
resolver
uniprot_entry
B4DUB4_HUMAN
resolver
uniprot_entry
ORAI2_HUMAN
resolver
uniprot_sec
Q6IA68
resolver
uniprot_sec
Q8WY94
resolver
uniprot_sec
Q9H9Y3
resolver
activity_regulation
ACTIVITY REGULATION: CRAC channels are regulated by fast Ca(2+)-dependent inactivation (FCDI), a mechanism that limits Ca(2+) influx and cell toxicity. ORAI2 channels display prominent FCDI (PubMed:19706554). Inhibited by lanthanides such as Gd(3+) ions (PubMed:16807233). {ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:19706554}.
uniprot
proteins
amino_acid_sequence
MSAELNVPIDPSAPACPEPGHKGMDYRDWVRRSYLELVTSNHHSVQALSWRKLYLSRAKLKASSRTSALLSGFAMVAMVEVQLETQYQYPRPLLIAFSACTTVLVAVHLFALLISTCILPNVEAVSNIHNLNSISESPHERMHPYIELAWGFSTVLGILLFLAEVVLLCWIKFLPVDARRQPGPPPGPGSHTGWQAALVSTIIMVPVGLIFVVFTIHFYRSLVRHKTERHNREIEELHKLKVQLDGHERSLQVL
uniprot
proteins
function
FUNCTION: Pore-forming subunit of inward rectifying Ca(2+) release-activated Ca(2+) (CRAC) channels. Assembles with ORAI1 and ORAI3 to form hexameric CRAC channels that mediate Ca(2+) influx upon depletion of endoplasmic reticulum Ca(2+) store and channel activation by Ca(2+) sensor STIM1, a process known as store-operated Ca(2+) entry (SOCE). Various pore subunit combinations may account for distinct CRAC channel spatiotemporal and cell-type specific dynamics. ORAI1 mainly contributes to the generation of Ca(2+) plateaus involved in sustained Ca(2+) entry and is dispensable for cytosolic Ca(2+) oscillations, whereas ORAI2 and ORAI3 generate oscillatory patterns. CRAC channels assemble in Ca(2+) signaling microdomains where Ca(2+) influx is coupled to calmodulin and calcineurin signaling and activation of NFAT transcription factors recruited to ORAI1 via AKAP5. CRAC channels are the main pathway for Ca(2+) influx in T cells and promote the immune response to pathogens by activating NFAT-dependent cytokine and chemokine transcription. {ECO:0000269|PubMed:16807233, ECO:0000269|PubMed:17442569, ECO:0000269|PubMed:17452328, ECO:0000269|PubMed:19182790, ECO:0000269|PubMed:19706554, ECO:0000269|PubMed:32415068, ECO:0000269|PubMed:33941685}.
uniprot
proteins
mass_dalton
28570
uniprot
proteins
mutagenesis
MUTAGEN 80; /note="E->Q: Has dominant negative effect. Impairs store-operated Ca(2+) influx. Decreases regenerative Ca(2+) oscillations."; /evidence="ECO:0000269|PubMed:32415068"; MUTAGEN 233; /note="E->A: Reduces fast Ca(2+)-dependent inactivation; when associated with A-235 and A-236."; /evidence="ECO:0000269|PubMed:19706554"; MUTAGEN 235; /note="E->A: Reduces fast Ca(2+)-dependent inactivation; when associated with A-233 and A-236."; /evidence="ECO:0000269|PubMed:19706554"; MUTAGEN 236; /note="E->A: Reduces fast Ca(2+)-dependent inactivation; when associated with A-233 and A-235."; /evidence="ECO:0000269|PubMed:19706554
uniprot
proteins
protein_family
Orai family
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
16582901
uniprot
proteins
pubmed
16807233
uniprot
proteins
pubmed
17442569
uniprot
proteins
pubmed
17452328
uniprot
proteins
pubmed
19182790
uniprot
proteins
pubmed
19706554
uniprot
proteins
pubmed
20418871
uniprot
proteins
pubmed
32415068
uniprot
proteins
pubmed
33941685
uniprot
proteins
sequence_length
254
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17452328}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with STIM1 upon store depletion. {ECO:0000269|PubMed:19706554}.
uniprot
proteins
transmembrane_region
TRANSMEM 66..83; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 94..114; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 148..168; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 196..216; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins