SCARA5
entrez
286133
canonical
uniprot
Q6ZMJ2
canonical
ensembl
ENSG00000168079
resolver
ensp
ENSP00000346990
resolver
ensp
ENSP00000428663
resolver
ensp
ENSP00000551606
resolver
genesymbol
SCARA5
resolver
hgnc
HGNC:28701
resolver
uniprot
Q6UXZ1
resolver
uniprot
Q7Z4A1
resolver
uniprot
Q8N4Z7
resolver
uniprot_entry
SCAR5_HUMAN
resolver
uniprot_sec
Q6UXZ1
resolver
uniprot_sec
Q7Z4A1
resolver
uniprot_sec
Q8N4Z7
resolver
amino_acid_sequence
MENKAMYLHTVSDCDTSSICEDSFDGRSLSKLNLCEDGPCHKRRASICCTQLGSLSALKHAVLGLYLLVFLILVGIFILAVSRPRSSPDDLKALTRNVNRLNESFRDLQLRLLQAPLQADLTEQVWKVQDALQNQSDSLLALAGAVQRLEGALWGLQAQAVQTEQAVALLRDRTGQQSDTAQLELYQLQVESNSSQLLLRRHAGLLDGLARRVGILGEELADVGGVLRGLNHSLSYDVALHRTRLQDLRVLVSNASEDTRRLRLAHVGMELQLKQELAMLNAVTEDLRLKDWEHSIALRNISLAKGPPGPKGDQGDEGKEGRPGIPGLPGLRGLPGERGTPGLPGPKGDDGKLGATGPMGMRGFKGDRGPKGEKGEKGDRAGDASGVEAPMMIRLVNGSGPHEGRVEVYHDRRWGTVCDDGWDKKDGDVVCRMLGFRGVEEVYRTARFGQGTGRIWMDDVACKGTEETIFRCSFSKWGVTNCGHAEDASVTCNRH
uniprot
proteins
function
FUNCTION: Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Preferentially binds ferritin light chain (FTL) compared to heavy chain (FTH1). {ECO:0000255|HAMAP-Rule:MF_03070}.
uniprot
proteins
mass_dalton
53994
uniprot
proteins
protein_family
SCARA5 family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
495
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_03070}; Single-pass type II membrane protein {ECO:0000255|HAMAP-Rule:MF_03070}.
uniprot
proteins
transmembrane_region
TRANSMEM 61..81; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255|HAMAP-Rule:MF_03070
uniprot
proteins