IL17C
entrez
27189
canonical
uniprot
Q9P0M4
canonical
ensembl
ENSG00000124391
resolver
ensp
ENSP00000244241
resolver
enst
ENST00000244241
resolver
genesymbol
IL17C
resolver
hgnc
HGNC:5983
resolver
uniprot
Q3MIG8
resolver
uniprot
Q9HC75
resolver
uniprot_entry
IL17C_HUMAN
resolver
uniprot_sec
Q3MIG8
resolver
uniprot_sec
Q9HC75
resolver
amino_acid_sequence
MTLLPGLLFLTWLHTCLAHHDPSLRGHPHSHGTPHCYSAEELPLGQAPPHLLARGAKWGQALPVALVSSLEAASHRGRHERPSATTQCPVLRPEEVLEADTHQRSISPWRYRVDTDEDRYPQKLAFAECLCRGCIDARTGRETAALNSVRLLQSLLVLRRRPCSRDGSGLPTPGAFAFHTEFIHVPVGCTCVLPRSV
uniprot
proteins
function
FUNCTION: Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and pro-inflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases. {ECO:0000269|PubMed:21993848}.
uniprot
proteins
mass_dalton
21765
uniprot
proteins
protein_family
IL-17 family
uniprot
proteins
pubmed
10639155
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21993848
uniprot
proteins
pubmed
21993849
uniprot
proteins
sequence_length
197
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins