Slc25a27
entrez
74011
canonical
uniprot
Q9D6D0
canonical
ensembl
ENSMUSG00000023912
resolver
ensp
ENSMUSP00000024705
resolver
ensp
ENSMUSP00000242034
resolver
ensp
ENSMUSP00000242037
resolver
enst
ENSMUST00000024705
resolver
genesymbol
Slc25a27
resolver
genesymbol_syn
UCP4
resolver
uniprot_entry
UCP4_MOUSE
resolver
amino_acid_sequence
MPIAEEEKLLPLTQRWPRTSKFLLSGCAATVAELATFPLDLTKTRLQMQGEAALARLGDGAVDSAPYRGMVRTALGIVQEEGFLKLWQGVTPAIYRHVVYSGGRMVTYEHLREVVFGKSEDKHYPLWKSVIGGMMAGVIGQFLANPTDLVKVQMQMEGKRRLEGKPLRFRGVHHAFAKILAEGGIRGLWAGWIPNIQRAALVNMGDLTTYDTVKHYLVLNTPLEDNISTHGLSSLCSGLVASILGTPADVIKSRIMNQPRDKQGRGLLYKSSADCLIQAVQGEGFLSLYKGFLPSWLRMTPWSMVFWLTYEKIREMSGVSPF
uniprot
proteins
function
FUNCTION: Facilitates proton transport across the inner mitochondrial membrane and may dissipate excessive proton gradient associated with oxidative and metabolic stress at neuronal synapses. Regulates glutamate-induced proton conductance in astrocytes, shifting the energy metabolism toward aerobic glycolysis and lactate transfer to neurons for ATP synthesis. Can transport chloride ions with lower efficiency. The transport mechanism remains to be elucidated. {ECO:0000250|UniProtKB:O95847, ECO:0000269|PubMed:25237189}.
uniprot
proteins
mass_dalton
35798
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
25237189
uniprot
proteins
pubmed
25535394
uniprot
proteins
sequence_length
322
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:25237189, ECO:0000269|PubMed:25535394}; Multi-pass membrane protein {ECO:0000255}. Cell projection, neuron projection {ECO:0000269|PubMed:25535394}. Note=Localizes to neuronal cell body and processes. Within mitochondrial inner membrane, it is mainly observed in the inner boundary membrane locally separated from F(1)F(0) ATP synthase, which is preferentially localized in cristae. {ECO:0000269|PubMed:25535394}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..39; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 87..108; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 126..143; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 194..211; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 228..247; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 287..310; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins