Q7TP65
uniprot
Q7TP65
canonical
amino_acid_sequence
MLWQRLAVVEWAALAWELLGASVLLIAVRWLVRRLENLSRDPNRCGTLSSLPGASAAVSAQPGEVMTMDAMLARLKLLNPDDLRQEVMKAGLKCGPITSTTRFIFEKKLAQALLEQGGLLTSSLPKHSEVTGTAFIHGTSRTPAFVDRKQTQQACLSEDRDFGYSVGLNPPEEEAVTSSVHPIPFSASTRNDNHKAGVTTAKEPLLYYGVCPVYEDGLVRHERIHVYEDKKEALQAVKLIKGSRFKAFPTREDAEKFARGICDYLPSPSKNMSLLSPVKAMPLCSNDGPKADGLCLAESETVNKERANSYKNPRTQDLTAKLRKAVERGEEHTFSDLIWSNPRYLIGSGDNPTIVQEGCRYNVMHVAAKENQASVCQLTLETLENPEFMRLMYPDDNMDMLQKRILYIVDLYLNTPDKVGFDTPLHFACKFGNVDVVNVLSSHPLIVKNPRNKYGKTPEDVICERSKNKSVELRERIREYLMGHYYVPLLRAEDTSPVIGELWSSDQKAEASSADHCRSSPRDPVMTLRAFVGPLSPSKAEDFRKLWKTPPRKKAGLFHSIRKSDPERGIERVGRELAHELGYPWVEYWEFLGCFVDLSSQEGLQRLEEYLIQKELNQKAQHEIGEEEGCLQDRTSDFGSGKKYSNSISVGAFLDGGDDISLEEVKNQQNTVPSQSQPSVDKFQNSKSGSPSLGQKADPGEAAVGFYPDNSRNGFCYPLNSRTADGRETEATNGEEALPPPVSILTQEFDKLNLQSLGDNLFETPNKNRELEDKILASSKGVVESGLASPAAIARLENKQVRTNSEVSEAMAEMSLGPNSPQLGVQAGLEPGFSSATADPTKRLFLSGEEPSKLDRDVLAALECAIIDPGLYPAVHRWKSTVMGYSPSDRQSWPSPALKGKFTTELVDLDCCHSCSGRSSPAGSSPSKPGHTTFSSGLHSPGRYSPAHGRHFQRVACMARLAAL
uniprot
proteins
function
FUNCTION: Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. May regulate nuclear localization of VRK1 in non-dividing cells. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. Involved in brain development. {ECO:0000250|UniProtKB:Q86XL3}.
uniprot
proteins
mass_dalton
106439
uniprot
proteins
protein_family
ANKLE2 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
964
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins