SUN1
entrez
23353
canonical
uniprot
O94901
canonical
ensembl
ENSG00000164828
resolver
ensp
ENSP00000374225
resolver
ensp
ENSP00000383947
resolver
ensp
ENSP00000384015
resolver
ensp
ENSP00000384116
resolver
ensp
ENSP00000395952
resolver
ensp
ENSP00000406653
resolver
ensp
ENSP00000409909
resolver
ensp
ENSP00000413439
resolver
ensp
ENSP00000551206
resolver
ensp
ENSP00000551207
resolver
ensp
ENSP00000551209
resolver
ensp
ENSP00000551211
resolver
ensp
ENSP00000551212
resolver
ensp
ENSP00000551214
resolver
ensp
ENSP00000551215
resolver
ensp
ENSP00000551216
resolver
ensp
ENSP00000551218
resolver
ensp
ENSP00000551219
resolver
ensp
ENSP00000551220
resolver
ensp
ENSP00000551221
resolver
ensp
ENSP00000551222
resolver
ensp
ENSP00000551225
resolver
ensp
ENSP00000551226
resolver
ensp
ENSP00000551234
resolver
ensp
ENSP00000551236
resolver
ensp
ENSP00000551239
resolver
ensp
ENSP00000587022
resolver
ensp
ENSP00000587028
resolver
ensp
ENSP00000587031
resolver
ensp
ENSP00000587035
resolver
ensp
ENSP00000633132
resolver
ensp
ENSP00000633149
resolver
ensp
ENSP00000633159
resolver
ensp
ENSP00000633178
resolver
ensp
ENSP00000633187
resolver
ensp
ENSP00000633200
resolver
ensp
ENSP00000633237
resolver
ensp
ENSP00000713554
resolver
enst
ENST00000405266
resolver
enst
ENST00000452783
resolver
enst
ENST00000881162
resolver
enst
ENST00000916963
resolver
enst
ENST00000963178
resolver
genesymbol
SUN1
resolver
genesymbol_syn
KIAA0810
resolver
genesymbol_syn
UNC84A
resolver
hgnc
HGNC:18587
resolver
uniprot
A0A146IHP0
resolver
uniprot
A0A8I5G938
resolver
uniprot
A5PL20
resolver
uniprot
B3KMV7
resolver
uniprot
B4DZF7
resolver
uniprot
B7WNY4
resolver
uniprot
B7WP53
resolver
uniprot
E9PDU4
resolver
uniprot
E9PF23
resolver
uniprot
E9PHI4
resolver
uniprot
F8WD13
resolver
uniprot
Q96CZ7
resolver
uniprot
Q9HA14
resolver
uniprot
Q9UH98
resolver
uniprot_entry
A0A146IHP0_HUMAN
resolver
uniprot_entry
A0A8I5G938_HUMAN
resolver
uniprot_entry
E9PHI4_HUMAN
resolver
uniprot_entry
SUN1_HUMAN
resolver
uniprot_sec
A5PL20
resolver
uniprot_sec
B3KMV7
resolver
uniprot_sec
B4DZF7
resolver
uniprot_sec
B7WNY4
resolver
uniprot_sec
B7WP53
resolver
uniprot_sec
E9PDU4
resolver
uniprot_sec
E9PF23
resolver
uniprot_sec
F8WD13
resolver
uniprot_sec
Q96CZ7
resolver
uniprot_sec
Q9HA14
resolver
uniprot_sec
Q9UH98
resolver
amino_acid_sequence
MDFSRLHMYSPPQCVPENTGYTYALSSSYSSDALDFETEHKLDPVFDSPRMSRRSLRLATTACTLGDGEAVGADSGTSSAVSLKNRAARTTKQRRSTNKSAFSINHVSRQVTSSGVSHGGTVSLQDAVTRRPPVLDESWIREQTTVDHFWGLDDDGDLKGGNKAAIQGNGDVGAAAATAHNGFSCSNCSMLSERKDVLTAHPAAPGPVSRVYSRDRNQKCYFLLQILRRIGAVGQAVSRTAWSALWLAVVAPGKAASGVFWWLGIGWYQFVTLISWLNVFLLTRCLRNICKFLVLLIPLFLLLAGLSLRGQGNFFSFLPVLNWASMHRTQRVDDPQDVFKPTTSRLKQPLQGDSEAFPWHWMSGVEQQVASLSGQCHHHGENLRELTTLLQKLQARVDQMEGGAAGPSASVRDAVGQPPRETDFMAFHQEHEVRMSHLEDILGKLREKSEAIQKELEQTKQKTISAVGEQLLPTVEHLQLELDQLKSELSSWRHVKTGCETVDAVQERVDVQVREMVKLLFSEDQQGGSLEQLLQRFSSQFVSKGDLQTMLRDLQLQILRNVTHHVSVTKQLPTSEAVVSAVSEAGASGITEAQARAIVNSALKLYSQDKTGMVDFALESGGGSILSTRCSETYETKTALMSLFGIPLWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMMIHPAAFTLEHIPKTLSPTGNISSAPKDFAVYGLENEYQEEGQLLGQFTYDQDGESLQMFQALKRPDDTAFQIVELRIFSNWGHPEYTCLYRFRVHGEPVK
uniprot
proteins
function
FUNCTION: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton (PubMed:18039933, PubMed:18396275). The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (By similarity). Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration (By similarity). Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly (By similarity). Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis (By similarity). Helps to define the distribution of nuclear pore complexes (NPCs) (By similarity). Required for efficient localization of SYNE4 in the nuclear envelope (By similarity). May be involved in nuclear remodeling during sperm head formation in spermatogenesis (By similarity). May play a role in DNA repair by suppressing non-homologous end joining repair to facilitate the repair of DNA cross-links (PubMed:24375709). {ECO:0000250|UniProtKB:Q9D666, ECO:0000269|PubMed:18039933, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:24375709}.
uniprot
proteins
mass_dalton
87110
uniprot
proteins
post_translational_modification
PTM: The disulfide bond with KASH domain-containing nesprins is required for stability of the respective LINC complexes under tensile forces. {ECO:0000250|UniProtKB:Q9UH99}.
uniprot
proteins
pubmed
10375507
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
12958361
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16445915
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17132086
uniprot
proteins
pubmed
17631499
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18039933
uniprot
proteins
pubmed
18396275
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18845190
uniprot
proteins
pubmed
19933576
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24375709
uniprot
proteins
pubmed
27956467
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28716842
uniprot
proteins
pubmed
9872452
uniprot
proteins
sequence_length
785
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000269|PubMed:12958361, ECO:0000269|PubMed:16445915, ECO:0000269|PubMed:17132086, ECO:0000269|PubMed:18845190, ECO:0000269|PubMed:19933576}; Single-pass type II membrane protein {ECO:0000269|PubMed:12958361, ECO:0000269|PubMed:16445915, ECO:0000269|PubMed:17132086, ECO:0000269|PubMed:18845190, ECO:0000269|PubMed:19933576}. Note=At oocyte MI stage localized around the spindle, at MII stage localized to the spindle poles. {ECO:0000250|UniProtKB:Q9D666}.
uniprot
proteins
transmembrane_region
TRANSMEM 289..308; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins