Tmed9
entrez
67511
canonical
uniprot
Q99KF1
canonical
ensembl
ENSMUSG00000058569
resolver
ensp
ENSMUSP00000105531
resolver
enst
ENSMUST00000109905
resolver
genesymbol
Tmed9
resolver
genesymbol_syn
Gp25l2
resolver
uniprot
Q6PDC2
resolver
uniprot
Q9CX02
resolver
uniprot_entry
Q6PDC2_MOUSE
resolver
uniprot_entry
TMED9_MOUSE
resolver
uniprot_sec
Q9CX02
resolver
amino_acid_sequence
MAAVRGVRVVGSSPGLLLGRGMRAFLLLLWLAARGSALYFHIGETEKKCFIEEIPDETMVIGNYRTQLYDKQREEYQPATPGLGMFVEVKDPEDKVILARQYGSEGRFTFTSHTPGEHQICLHSNSTKFSLFAGGMLRVHLDIQVGEHANDYAEIAAKDKLSELQLRVRQLVEQVEQIQKEQNYQRWREERFRQTSESTNQRVLWWSILQTLILVAIGVWQMRHLKSFFEAKKLV
uniprot
proteins
function
FUNCTION: Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
27127
uniprot
proteins
post_translational_modification
PTM: N-linked glycosylated containing high mannose. {ECO:0000250}.
uniprot
proteins
protein_family
EMP24/GP25L family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
235
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Cycles between compartments of the early secretatory pathway. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 203..222; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins