Rnf40
entrez
266712
canonical
uniprot
Q8CJB9
canonical
ensembl
ENSRNOG00000018840
resolver
ensp
ENSRNOP00000025500
resolver
ensp
ENSRNOP00000094962
resolver
enst
ENSRNOT00000025499
resolver
genesymbol
Rnf40
resolver
genesymbol_syn
Bre1b
resolver
uniprot
A0A8L2UK73
resolver
uniprot_entry
A0A8L2UK73_RAT
resolver
uniprot_entry
BRE1B_RAT
resolver
amino_acid_sequence
MSGLSNKRAAGDGGSGPPEKKLNREEKTTTTLIEPIRLGGISSTEEMDSKVLQFKNKKLAERLEQRQACEDELRERIEKLEKRQATDDATLLIVNRYWAQLDETVEALLQCYENQRELSSSGTEVPGCQEGLTRDVIPRTDPGTSDLREPLPMQFRAPLSEPALAFVVALGASSCEEVELQLQGRMEFSKAAVSRVVEASDRLQRQVEELCQRVYSRGDSEAPGEVARARTRELGRENRRLQDLATQLQEKHHRISLEYSELQDKVTSTETKVLEMETTVEDLQWDIEKLRKREQKLNKHLAEALEQLNSGYYVSGSSTGFQGGQITLSMQKFEMLNAELEENQELANSRMAELEKLQAELQGAVRTNERLKVALRSLPEEVVRETGEYRMLQAQFSLLYNESLQVKTQLDEARGLLLASKNSHLRHIEHMESDELGLQKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQNLAANEQAGPINREMRHLISSLQNHNHQLKGDAQRYKRKLREVQAEIGKLRAQASGSSHCGPNLSHPDDSGLNALAPGKEDSGPGPGGTPDSKKELALVAGATSVASSVKKEELVSSEDDAQALAPGTQGLPSRGREPEARPKRELREREGPSLGPPPAASTLSRADREKAKAEEARRKESELLKGLRAELKKAQESQKEMKLLLDMYKSAPKEQRDKVQLMAAERKAKAEVDELRSRIRDLEERDRRESKKIADEDALRRIRQAEEQIEHLQRKLGATKQEEEALLSEMDVTGQAFEDMQEQNGRLLQQLREKDDANFKLMSERIKANQIHKLLREEKDELGEQVLGLKSQVDAQLLTVQKLEEKERALQGSLGGVEKELTLRSQALELNKRKAVEAAQLAEDLKVQLEHVQTRLREIQPCLAESRAAREKESFNLKRAQEDISRLRRKLEKQRKVEVYADADEILQEEIKEYKARLTCPCCNTRKKDAVLTKCFHVFCFECVRGRYEARQRKCPKCNAAFGAHDFHRVYIS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. {ECO:0000250|UniProtKB:O75150}.
uniprot
proteins
mass_dalton
113841
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
BRE1 family
uniprot
proteins
pubmed
12121982
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
1002
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O75150}.
uniprot
proteins