DKK2
entrez
27123
canonical
uniprot
Q9UBU2
canonical
ensembl
ENSG00000155011
resolver
ensp
ENSP00000285311
resolver
enst
ENST00000285311
resolver
genesymbol
DKK2
resolver
hgnc
HGNC:2892
resolver
uniprot
A0AVE9
resolver
uniprot
B2R6S7
resolver
uniprot
Q9UIU3
resolver
uniprot_entry
DKK2_HUMAN
resolver
uniprot_sec
A0AVE9
resolver
uniprot_sec
B2R6S7
resolver
uniprot_sec
Q9UIU3
resolver
amino_acid_sequence
MAALMRSKDSSCCLLLLAAVLMVESSQIGSSRAKLNSIKSSLGGETPGQAANRSAGMYQGLAFGGSKKGKNLGQAYPCSSDKECEVGRYCHSPHQGSSACMVCRRKKKRCHRDGMCCPSTRCNNGICIPVTESILTPHIPALDGTRHRDRNHGHYSNHDLGWQNLGRPHTKMSHIKGHEGDPCLRSSDCIEGFCCARHFWTKICKPVLHQGEVCTKQRKKGSHGLEIFQRCDCAKGLSCKVWKDATYSSKARLHVCQKI
uniprot
proteins
function
FUNCTION: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
28447
uniprot
proteins
post_translational_modification
PTM: May be proteolytically processed by a furin-like protease.
uniprot
proteins
protein_family
Dickkopf family
uniprot
proteins
pubmed
10570958
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17143291
uniprot
proteins
sequence_length
259
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins