MINDY1
entrez
55793
canonical
uniprot
Q8N5J2
canonical
ensembl
ENSG00000143409
resolver
ensp
ENSP00000310923
resolver
ensp
ENSP00000354669
resolver
ensp
ENSP00000354814
resolver
ensp
ENSP00000437174
resolver
ensp
ENSP00000507359
resolver
ensp
ENSP00000601164
resolver
ensp
ENSP00000613059
resolver
ensp
ENSP00000660006
resolver
ensp
ENSP00000660007
resolver
ensp
ENSP00000694759
resolver
genesymbol
MINDY1
resolver
genesymbol_syn
FAM63A
resolver
genesymbol_syn
KIAA1390
resolver
hgnc
HGNC:25648
resolver
uniprot
B3KWP4
resolver
uniprot
B3KWV8
resolver
uniprot
B4DXF2
resolver
uniprot
B4E1S4
resolver
uniprot
D3DV09
resolver
uniprot
J3KP53
resolver
uniprot
Q5SZF0
resolver
uniprot
Q9NUL9
resolver
uniprot
Q9P2F7
resolver
uniprot_entry
MINY1_HUMAN
resolver
uniprot_sec
B3KWP4
resolver
uniprot_sec
B3KWV8
resolver
uniprot_sec
B4DXF2
resolver
uniprot_sec
B4E1S4
resolver
uniprot_sec
D3DV09
resolver
uniprot_sec
J3KP53
resolver
uniprot_sec
Q5SZF0
resolver
uniprot_sec
Q9NUL9
resolver
uniprot_sec
Q9P2F7
resolver
amino_acid_sequence
MEYHQPEDPAPGKAGTAEAVIPENHEVLAGPDEHPQDTDARDADGEAREREPADQALLPSQCGDNLESPLPEASSAPPGPTLGTLPEVETIRACSMPQELPQSPRTRQPEPDFYCVKWIPWKGEQTPIITQSTNGPCPLLAIMNILFLQWKVKLPPQKEVITSDELMAHLGNCLLSIKPQEKSEGLQLNFQQNVDDAMTVLPKLATGLDVNVRFTGVSDFEYTPECSVFDLLGIPLYHGWLVDPQSPEAVRAVGKLSYNQLVERIITCKHSSDTNLVTEGLIAEQFLETTAAQLTYHGLCELTAAAKEGELSVFFRNNHFSTMTKHKSHLYLLVTDQGFLQEEQVVWESLHNVDGDSCFCDSDFHLSHSLGKGPGAEGGSGSPETQLQVDQDYLIALSLQQQQPRGPLGLTDLELAQQLQQEEYQQQQAAQPVRMRTRVLSLQGRGATSGRPAGERRQRPKHESDCILL
uniprot
proteins
ec_number
3.4.19.12
uniprot
proteins
function
FUNCTION: Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover. {ECO:0000269|PubMed:27292798, ECO:0000269|PubMed:28082312}.
uniprot
proteins
mass_dalton
51778
uniprot
proteins
mutagenesis
MUTAGEN 131; /note="Q->A,E: Abolishes ubiquitin hydrolase activity."; /evidence="ECO:0000269|PubMed:27292798"; MUTAGEN 137; /note="C->A: Abolishes ubiquitin hydrolase activity."; /evidence="ECO:0000269|PubMed:27292798"; MUTAGEN 209; /note="D->A: Abolishes ubiquitin hydrolase activity."; /evidence="ECO:0000269|PubMed:27292798"; MUTAGEN 210; /note="V->A: Greatly impairs ubiquitin hydrolase activity."; /evidence="ECO:0000269|PubMed:27292798"; MUTAGEN 240; /note="W->A: Abolishes ubiquitin hydrolase activity."; /evidence="ECO:0000269|PubMed:27292798"; MUTAGEN 258; /note="Y->A: Abolishes ubiquitin hydrolase activity."; /evidence="ECO:0000269|PubMed:27292798"; MUTAGEN 263; /note="E->A: Greatly impairs ubiquitin hydrolase activity."; /evidence="ECO:0000269|PubMed:27292798"; MUTAGEN 263; /note="E->R: Abolishes ubiquitin hydrolase activity."; /evidence="ECO:0000269|PubMed:27292798"; MUTAGEN 315; /note="F->A: Abolishes ubiquitin hydrolase activity."; /evidence="ECO:0000269|PubMed:27292798"; MUTAGEN 319; /note="H->A: Abolishes ubiquitin hydrolase activity."; /evidence="ECO:0000269|PubMed:27292798"; MUTAGEN 396; /note="A->G: No effect on binding to 'Lys-48' tetraubiquitin chains."; /evidence="ECO:0000269|PubMed:28082312"; MUTAGEN 408; /note="L->A: No effect on binding to 'Lys-48' tetraubiquitin chains."; /evidence="ECO:0000269|PubMed:28082312"; MUTAGEN 411; /note="T->A: No effect on binding to 'Lys-48' tetraubiquitin chains."; /evidence="ECO:0000269|PubMed:28082312"; MUTAGEN 412; /note="D->A: Loss of binding to 'Lys-48' tetraubiquitin chains."; /evidence="ECO:0000269|PubMed:28082312"; MUTAGEN 413; /note="L->A: No effect on binding to 'Lys-48' tetraubiquitin chains."; /evidence="ECO:0000269|PubMed:28082312"; MUTAGEN 414; /note="E->A: No effect on binding to 'Lys-48' tetraubiquitin chains."; /evidence="ECO:0000269|PubMed:28082312"; MUTAGEN 415..416; /note="LA->AG: Decreased association with 'Lys-48'-linked conjugated ubiquitin."; /evidence="ECO:0000269|PubMed:27292798"; MUTAGEN 415; /note="L->A: Loss of binding to 'Lys-48' tetraubiquitin chains."; /evidence="ECO:0000269|PubMed:28082312"; MUTAGEN 416; /note="A->G,D: Loss of binding to 'Lys-48' tetraubiquitin chains."; /evidence="ECO:0000269|PubMed:28082312"; MUTAGEN 416; /note="A->S: No effect on binding to 'Lys-48' tetraubiquitin chains."; /evidence="ECO:0000269|PubMed:28082312"; MUTAGEN 418; /note="Q->A,K: No effect on binding to 'Lys-48' tetraubiquitin chains."; /evidence="ECO:0000269|PubMed:28082312"; MUTAGEN 419; /note="L->A: Loss of binding to 'Lys-48' tetraubiquitin chains."; /evidence="ECO:0000269|PubMed:28082312"; MUTAGEN 420; /note="Q->A: Loss of binding to 'Lys-48' tetraubiquitin chains."; /evidence="ECO:0000269|PubMed:28082312"; MUTAGEN 421; /note="Q->E,R: No effect on binding to 'Lys-48' tetraubiquitin chains."; /evidence="ECO:0000269|PubMed:28082312"; MUTAGEN 422; /note="E->A: No effect on binding to 'Lys-48' tetraubiquitin chains."; /evidence="ECO:0000269|PubMed:28082312"; MUTAGEN 423; /note="E->A: Loss of binding to 'Lys-48' tetraubiquitin chains."; /evidence="ECO:0000269|PubMed:28082312"; MUTAGEN 423; /note="E->EA,EAAA,EAAAAAA,EAAAAAAA: Loss of binding to 'Lys-48' tetraubiquitin chains."; /evidence="ECO:0000269|PubMed:28082312"; MUTAGEN 423; /note="Missing: Loss of binding to 'Lys-48' tetraubiquitin chains."; /evidence="ECO:0000269|PubMed:28082312"; MUTAGEN 424; /note="Y->A,D,E: Decreased binding to 'Lys-48' tetraubiquitin chains."; /evidence="ECO:0000269|PubMed:28082312"; MUTAGEN 424; /note="Y->F,W: No effect on binding to 'Lys-48' tetraubiquitin chains."; /evidence="ECO:0000269|PubMed:28082312
uniprot
proteins
protein_family
FAM63 subfamily
uniprot
proteins
protein_family
MINDY deubiquitinase family
uniprot
proteins
pubmed
10718198
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27292798
uniprot
proteins
pubmed
28082312
uniprot
proteins
sequence_length
469
uniprot
proteins