Lyst
entrez
17101
canonical
uniprot
P97412
canonical
ensembl
ENSMUSG00000019726
resolver
ensp
ENSMUSP00000106188
resolver
enst
ENSMUST00000110559
resolver
genesymbol
Lyst
resolver
genesymbol_syn
Bg
resolver
genesymbol_syn
Chs1
resolver
uniprot
G5E8Q0
resolver
uniprot
Q62403
resolver
uniprot
Q8VBS6
resolver
uniprot_entry
G5E8Q0_MOUSE
resolver
uniprot_entry
LYST_MOUSE
resolver
uniprot_sec
Q62403
resolver
uniprot_sec
Q8VBS6
resolver
amino_acid_sequence
MSTDSNSLAREFLIDVNQLCNAVVQRAEAREEEEEETHMATLGQYLVHGRGFLLLTKLNSIIDQALTCREELLTLLLSLLPLVWKIPVQEQQATDFNLPLSSDIILTKEKNSSLQKSTQGKLYLEGSAPSGQVSAKVNLFRKIRRQRKSTHRYSVRDARKTQLSTSDSEGNSDEKSTVVSKHRRLHALPRFLTQSPKEGHLVAKPDPSATKEQVLSDTMSVENSREVILRQDSNGDILSEPAALSILSNMNNSPFDLCHVLLSLLEKVCKFDIALNHNSSLALSVVPTLTEFLAGFGDCCNQSDTLEGQLVSAGWTEEPVALVQRMLFRTVLHLMSVDVSTAEAMPESLRKNLTELLRAALKIRACLEKQPEPFSPRQKKTLQEVQEGFVFSKYRHRALLLPELLEGVLQLLISCLQSAASNPFYFSQAMDLVQEFIQHQGFNLFGTAVLQMEWLLTRDGVPSEAAEHLKALINSVIKIMSTVKKVKSEQLHHSMCTRKRHRRCEYSHFMQHHRDLSGLLVSAFKNQLSKSPFEETAEGDVQYPERCCCIAVCAHQCLRLLQQVSLSTTCVQILSGVHSVGICCCMDPKSVIAPLLHAFKLPALKAFQQHILNVLSKLLVDQLGGAELSPRIKKAACNICTVDSDQLAKLGETLQGTLCGAGPTSGLPSPSYRFQGILPSSGSEDLLWKWDALEAYQSFVFQEDRLHNIQIANHICNLLQKGNVVVQWKLYNYIFNPVLQRGVELVHHCQQLSIPSAQTHMCSQLKQYLPQEVLQIYLKTLPVLLKSRVIRDLFLSCNGVNHIIELNYLDGIRSHSLKAFETLIVSLGEQQKDAAVLDVDGLDIQQELPSLSVGPSLHKQQASSDSPCSLRKFYASLREPDPKKRKTIHQDVHINTINLFLCVAFLCVSKEADSDRESANESEDTSGYDSPPSEPLSHMLPCLSLEDVVLPSPECLHHAADIWSMCRWIYMLNSVFQKQFHRLGGFQVCHELIFMIIQKLFRSHTEDQGRRQGEMSRNENQELIRISYPELTLKGDVSSATAPDLGFLRKSADSVRGFQSQPVLPTSAEQIVATESVPGERKAFMSQQSETSLQSIRLLESLLDICLHSARACQQKMELELPSQGLSVENILCELREHLSQSKVAETELAKPLFDALLRVALGNHSADLGPGDAVTEKSHPSEEELLSQPGDFSEEAEDSQCCSLKLLGEEEGYEADSESNPEDVDTQDDGVELNPEAEGFSGSIVSNNLLENLTHGEIIYPEICMLGLNLLSASKAKLDVLAHVFESFLKIVRQKEKNISLLIQQGTVKILLGGFLNILTQTNSDFQACQRVLVDLLVSLMSSRTCSEDLTLLWRIFLEKSPCTEILLLGIHKIVESDFTMSPSQCLTFPFLHTPSLSNGVLSQKPPGILNSKALGLLRRARISRGKKEADRESFPYRLLSSWHIAPIHLPLLGQNCWPHLSEGFSVSLVGLMWNTSNESESAAERGKRVKKRNKPSVLEDSSFEGAEGDRPEVTESINPGDRLIEDGCIHLISLGSKALMIQVWADPHSGTFIFRVCMDSNDDTKAVSLAQVESQENIFFPSKWQHLVLTYIQHPQGKKNVHGEISIWVSGQRKTDVILDFVLPRKTSLSSDSNKTFCMIGHCLTSQEESLQLAGKWDLGNLLLFNGAKIGSQEAFFLYACGPNYTSIMPCKYGQPVIDYSKYINKDILRCDEIRDLFMTKKEVDVGLLIESLSVVYTTCCPAQYTIYEPVIRLKGQVKTQPSQRPFSSKEAQSILLEPSQLKGLQPTECKAIQGILHEIGGAGTFVFLFARVVELSSCEETQALALRVILSLIKYSQQRTQELENCNGLSMIHQVLVKQKCIVGFHILKTLLEGCCGEEVIHVSEHGEFKLDVESHAIIQDVKLLQELLLDWKIWNKAEQGVWETLLAALEVLIRVEHHQQQFNIKQLLNAHVVHHFLLTCQVLQEHREGQLTSMPREVCRSFVKIIAEVLGSPPDLELLTVIFNFLLAVHPPTNTYVCHNPTNFYFSLHIDGKIFQEKVQSLAYLRHSSSGGQAFPSPGFLVISPSAFTAAPPEGTSSSNIVPQRMAAQMVRSRSLPAFPTYLPLIRAQKLAASLGFSVDKLQNIADANPEKQNLLGRPYALKTSKEEAFISSCESAKTVCEMEALLGAHASANGVSRGSPRFPRARVDHKDVGTEPRSDDDSPGDESYPRRPDNLKGLASFQRSQSTVASLGLAFPSQNGSAVASRWPSLVDRNADDWENFTFSPAYEASYNRATSTHSVIEDCLIPICCGLYELLSGVLLVLPDAMLEDVMDRIIQADILLVLVNHPSPAIQQGVIKLLHAYINRASKEQKDKFLKNRGFSLLANQLYLHRGTQELLECFVEMFFGRPIGLDEEFDLEEVKHMELFQKWSVIPVLGLIETSLYDNVLLHNALLLLLQVLNSCSKVADMLLDNGLLYVLCNTVAALNGLEKNIPVNEYKLLACDIQQLFIAVTIHACSSSGTQYFRVIEDLIVLLGYLHNSKNKRTQNMALALQLRVLQAALEFIRSTANHDSESPVHSPSAHRHSVPPKRRSIAGSRKFPLAQTESLLMKMRSVASDELHSMMQRRMSQEHPSQASEAELAQRLQRLTILAVNRIIYQELNSDIIDILRTPENTSQSKTSVSQTEISEEDMHHEQPSVYNPFQKEMLTYLLDGFKVCIGSSKTSVSKQQWTKILGSCKETLRDQLGRLLAHILSPTHTVQERKQILEIVHEPAHQDILRDCLSPSPQHGAKLVLYLSELIHNHQDELSEEEMDTAELLMNALKLCGHKCIPPSAPSKPELIKIIREEQKKYESEESVSKGSWQKTVNNNQQSLFQRLDFKSKDISKIAADITQAVSLSQGIERKKVIQHIRGMYKVDLSASRHWQECIQQLTHDRAVWYDPIYYPTSWQLDPTEGPNRERRRLQRCYLTIPNKYLLRDRQKSEGVLRPPLSYLFEDKTHSSFSSTVKDKAASESIRVNRRCISVAPSRETAGELLLGKCGMYFVEDNASDAVESSSLQGELEPASFSWTYEEIKEVHRRWWQLRDNAVEIFLTNGRTLLLAFDNNKVRDDVYQSILTNNLPNLLEYGNITALTNLWYSGQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILSDYVSETLDLNDPSIYRNLSKPIAVQYKEKEDRYVDTYKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGTVLHFLVRMPPFTKMFLAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYLPEFLVNREGFDFGVRQNGERVNHVNLPPWARNDPRLFILIHRQALESDHVSQNICHWIDLVFGYKQKGKASVQAINVFHPATYFGMDVSAVEDPVQRRALETMIKTYGQTPRQLFHTAHASRPGAKLNIEGELPAAVGLLVQFAFRETREPVKEVTHPSPLSWIKGLKWGEYVGSPSAPVPVVCFSQPHGERFGSLQALPTRAICGLSRNFCLLMTYNKEQGVRSMNNTNIQWSAILSWGYADNILRLKSKQSEPPINFIQSSQQHQVTSCAWVPDSCQLFTGSKCGVITAYTNRLTSSTPSEIEMESQMHLYGHTEEITGLCVCKPYSVMISVSRDGTCIVWDLNRLCYVQSLAGHKSPVTAVSASETSGDIATVCDSAGGGSDLRLWTVNGDLVGHVHCREIICSVAFSNQPEGVSINVIAGGLENGIVRLWSTWDLKPVREITFPKSNKPIISLTFSCDGHHLYTANSEGTVIAWCRKDQQRVKLPMFYSFLSSYAAG
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Lyst are the cause of beige (bg), an autosomal recessive disorder characterized by hypopigmentation, bleeding, immune cell dysfunction, abnormal intracellular transport to and from the lysosome, and giant inclusion bodies in a variety of cell types. {ECO:0000269|PubMed:27881733, ECO:0000269|PubMed:9215680}.
uniprot
proteins
function
FUNCTION: Adapter protein that regulates and/or fission of intracellular vesicles such as lysosomes (By similarity). Might regulate trafficking of effectors involved in exocytosis (By similarity). In cytotoxic T-cells and natural killer (NK) cells, has role in the regulation of size, number and exocytosis of lytic granules (By similarity). In macrophages and dendritic cells, regulates phagosome maturation by controlling the conversion of early phagosomal compartments into late phagosomes (PubMed:27881733). In macrophages and dendritic cells, specifically involved in TLR3- and TLR4-induced production of pro-inflammatory cytokines by regulating the endosomal TLR3- TICAM1/TRIF and TLR4- TICAM1/TRIF signaling pathways (PubMed:27881733). {ECO:0000250|UniProtKB:Q99698, ECO:0000269|PubMed:27881733}.
uniprot
proteins
mass_dalton
425287
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27881733
uniprot
proteins
pubmed
8673129
uniprot
proteins
pubmed
8717042
uniprot
proteins
pubmed
9215680
uniprot
proteins
sequence_length
3788
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
uniprot
proteins