PAGE4
entrez
9506
canonical
uniprot
O60829
canonical
ensembl
ENSG00000101951
resolver
ensp
ENSP00000218068
resolver
ensp
ENSP00000365311
resolver
ensp
ENSP00000520416
resolver
ensp
ENSP00000520417
resolver
ensp
ENSP00000582073
resolver
ensp
ENSP00000582075
resolver
ensp
ENSP00000637103
resolver
ensp
ENSP00000761081
resolver
enst
ENST00000218068
resolver
enst
ENST00000376141
resolver
enst
ENST00000715210
resolver
enst
ENST00000715211
resolver
enst
ENST00000912014
resolver
enst
ENST00000912016
resolver
enst
ENST00000967044
resolver
genesymbol
PAGE4
resolver
genesymbol_syn
GAGEC1
resolver
hgnc
HGNC:4108
resolver
uniprot
B2R529
resolver
uniprot
D3DX68
resolver
uniprot
Q6IBI1
resolver
uniprot_entry
PAGE4_HUMAN
resolver
uniprot_sec
B2R529
resolver
uniprot_sec
D3DX68
resolver
uniprot_sec
Q6IBI1
resolver
amino_acid_sequence
MSARVRSRSRGRGDGQEAPDVVAFVAPGESQQEEPPTDNQDIEPGQEREGTPPIEERKVEGDCQEMDLEKTRSERGDGSDVKEKTPPNPKHAKTKEAGDGQP
uniprot
proteins
function
FUNCTION: Intrinsically disordered protein that potentiates the transcriptional activator activity of JUN (PubMed:24263171, PubMed:28289210). Protects cells from stress-induced apoptosis by inhibiting reactive oxygen species (ROS) production and via regulation of the MAPK signaling pathway (PubMed:21357425, PubMed:25374899, PubMed:30658679). {ECO:0000269|PubMed:21357425, ECO:0000269|PubMed:24263171, ECO:0000269|PubMed:25374899, ECO:0000269|PubMed:28289210, ECO:0000269|PubMed:30658679}.
uniprot
proteins
mass_dalton
11153
uniprot
proteins
mutagenesis
MUTAGEN 51; /note="T->A: Loss of phosphorylation and its ability to potentiate JUN transcriptional activator activity."; /evidence="ECO:0000269|PubMed:24263171
uniprot
proteins
post_translational_modification
PTM: HIPK1-mediated phosphorylation at Thr-51 leads to the compaction of its intrinsically disordered conformation and is critical for its ability to potentiate the transcriptional activator activity of JUN inspite of a reduced interaction with JUN (PubMed:24559171, PubMed:26242913). CLK2-mediated phosphorylation at multiple Ser and Thr residues attenuates its ability to potentiate JUN transcriptional activator activity (PubMed:28289210). {ECO:0000269|PubMed:24559171, ECO:0000269|PubMed:26242913, ECO:0000269|PubMed:28289210}.
uniprot
proteins
protein_family
GAGE family
uniprot
proteins
pubmed
12489849
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
21357425
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24263171
uniprot
proteins
pubmed
24559171
uniprot
proteins
pubmed
25374899
uniprot
proteins
pubmed
26242913
uniprot
proteins
pubmed
27270343
uniprot
proteins
pubmed
28289210
uniprot
proteins
pubmed
30658679
uniprot
proteins
pubmed
9724777
uniprot
proteins
sequence_length
102
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12489849, ECO:0000269|PubMed:24559171, ECO:0000269|PubMed:25374899}. Nucleus {ECO:0000269|PubMed:24559171}. Mitochondrion {ECO:0000269|PubMed:25374899}. Note=Translocates to mitochondria in response to stress. {ECO:0000269|PubMed:25374899}.
uniprot
proteins