CHAF1A
entrez
10036
canonical
uniprot
Q13111
canonical
ensembl
ENSG00000167670
resolver
ensp
ENSP00000301280
resolver
genesymbol
CHAF1A
resolver
genesymbol_syn
CAF
resolver
genesymbol_syn
CAF1P150
resolver
hgnc
HGNC:1910
resolver
uniprot
Q6NXG5
resolver
uniprot
Q7Z7K3
resolver
uniprot
Q9UJY8
resolver
uniprot_entry
CAF1A_HUMAN
resolver
uniprot_sec
Q6NXG5
resolver
uniprot_sec
Q7Z7K3
resolver
uniprot_sec
Q9UJY8
resolver
amino_acid_sequence
MLEELECGAPGARGAATAMDCKDRPAFPVKKLIQARLPFKRLNLVPKGKADDMSDDQGTSVQSKSPDLEASLDTLENNCHVGSDIDFRPKLVNGKGPLDNFLRNRIETSIGQSTVIIDLTEDSNEQPDSLVDHNKLNSEASPSREAINGQREDTGDQQGLLKAIQNDKLAFPGETLSDIPCKTEEEGVGCGGAGRRGDSQECSPRSCPELTSGPRMCPRKEQDSWSEAGGILFKGKVPMVVLQDILAVRPPQIKSLPATPQGKNMTPESEVLESFPEEDSVLSHSSLSSPSSTSSPEGPPAPPKQHSSTSPFPTSTPLRRITKKFVKGSTEKNKLRLQRDQERLGKQLKLRAEREEKEKLKEEAKRAKEEAKKKKEEEKELKEKERREKREKDEKEKAEKQRLKEERRKERQEALEAKLEEKRKKEEEKRLREEEKRIKAEKAEITRFFQKPKTPQAPKTLAGSCGKFAPFEIKEHMVLAPRRRTAFHPDLCSQLDQLLQQQSGEFSFLKDLKGRQPLRSGPTHVSTRNADIFNSDVVIVERGKGDGVPERRKFGRMKLLQFCENHRPAYWGTWNKKTALIRARDPWAQDTKLLDYEVDSDEEWEEEEPGESLSHSEGDDDDDMGEDEDEDDGFFVPHGYLSEDEGVTEECADPENHKVRQKLKAKEWDEFLAKGKRFRVLQPVKIGCVWAADRDCAGDDLKVLQQFAACFLETLPAQEEQTPKASKRERRDEQILAQLLPLLHGNVNGSKVIIREFQEHCRRGLLSNHTGSPRSPSTTYLHTPTPSEDAAIPSKSRLKRLISENSVYEKRPDFRMCWYVHPQVLQSFQQEHLPVPCQWSYVTSVPSAPKEDSGSVPSTGPSQGTPISLKRKSAGSMCITQFMKKRRHDGQIGAEDMDGFQADTEEEEEEEGDCMIVDVPDAAEVQAPCGAASGAGGGVGVDTGKATLTASPLGAS
uniprot
proteins
function
FUNCTION: Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci. {ECO:0000250|UniProtKB:Q5R1T0}.
uniprot
proteins
mass_dalton
106910
uniprot
proteins
mutagenesis
MUTAGEN 240; /note="V->E: Abolishes interaction with CBX5; when associated with E-242."; /evidence="ECO:0000269|PubMed:20562864"; MUTAGEN 242; /note="L->E: Abolishes interaction with CBX5; when associated with E-240."; /evidence="ECO:0000269|PubMed:20562864
uniprot
proteins
protein_family
CHAF1A family
uniprot
proteins
pubmed
10052459
uniprot
proteins
pubmed
10648606
uniprot
proteins
pubmed
10893180
uniprot
proteins
pubmed
11250073
uniprot
proteins
pubmed
11296234
uniprot
proteins
pubmed
12697822
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15327775
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15882967
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20562864
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
30849389
uniprot
proteins
pubmed
33857403
uniprot
proteins
pubmed
7600578
uniprot
proteins
sequence_length
956
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10052459}. Note=DNA replication foci.
uniprot
proteins