STOML2
entrez
30968
canonical
uniprot
Q9UJZ1
canonical
ensembl
ENSG00000165283
resolver
ensp
ENSP00000348886
resolver
ensp
ENSP00000395743
resolver
ensp
ENSP00000481672
resolver
enst
ENST00000619795
resolver
genesymbol
STOML2
resolver
genesymbol_syn
SLP2
resolver
hgnc
HGNC:14559
resolver
uniprot
A0A087WYB4
resolver
uniprot
B4E1K7
resolver
uniprot
D3DRN3
resolver
uniprot
O60376
resolver
uniprot
Q53G29
resolver
uniprot
Q96FY2
resolver
uniprot
Q9P042
resolver
uniprot_entry
A0A087WYB4_HUMAN
resolver
uniprot_entry
STML2_HUMAN
resolver
uniprot_sec
B4E1K7
resolver
uniprot_sec
D3DRN3
resolver
uniprot_sec
O60376
resolver
uniprot_sec
Q53G29
resolver
uniprot_sec
Q96FY2
resolver
uniprot_sec
Q9P042
resolver
amino_acid_sequence
MLARAARGTGALLLRGSLLASGRAPRRASSGLPRNTVVLFVPQQEAWVVERMGRFHRILEPGLNILIPVLDRIRYVQSLKEIVINVPEQSAVTLDNVTLQIDGVLYLRIMDPYKASYGVEDPEYAVTQLAQTTMRSELGKLSLDKVFRERESLNASIVDAINQAADCWGIRCLRYEIKDIHVPPRVKESMQMQVEAERRKRATVLESEGTRESAINVAEGKKQAQILASEAEKAEQINQAAGEASAVLAKAKAKAEAIRILAAALTQHNGDAAASLTVAEQYVSAFSKLAKDSNTILLPSNPGDVTSMVAQAMGVYGALTKAPVPGTPDSLSSGSSRDVQGTDASLDEELDRVKMS
uniprot
proteins
function
FUNCTION: Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation. {ECO:0000269|PubMed:17121834, ECO:0000269|PubMed:18641330, ECO:0000269|PubMed:19597348, ECO:0000269|PubMed:19944461, ECO:0000269|PubMed:21746876, ECO:0000269|PubMed:22623988}.
uniprot
proteins
mass_dalton
38534
uniprot
proteins
post_translational_modification
PTM: Hyperphosphorylated at Ser-17 in some patients with monoclonal gammopathy of undetermined significance (MGUS), multiple myeloma (MM) and Waldenstrom macroglobulinemia due to impaired dephosphorylation by PP2A.
uniprot
proteins
protein_family
Band 7/mec-2 family
uniprot
proteins
pubmed
10713127
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
11435687
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16671055
uniprot
proteins
pubmed
17121834
uniprot
proteins
pubmed
18339324
uniprot
proteins
pubmed
18641330
uniprot
proteins
pubmed
19405124
uniprot
proteins
pubmed
19597348
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19944461
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21746876
uniprot
proteins
pubmed
21791414
uniprot
proteins
pubmed
22623988
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
37463214
uniprot
proteins
sequence_length
356
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10713127, ECO:0000269|PubMed:18641330, ECO:0000269|PubMed:21746876, ECO:0000269|PubMed:22623988}; Peripheral membrane protein {ECO:0000269|PubMed:10713127}. Mitochondrion {ECO:0000269|PubMed:18641330, ECO:0000269|PubMed:19597348, ECO:0000269|PubMed:22623988}. Mitochondrion inner membrane {ECO:0000269|PubMed:17121834, ECO:0000269|PubMed:18339324, ECO:0000269|PubMed:21746876}; Lipid-anchor {ECO:0000269|PubMed:21746876}. Mitochondrion intermembrane space {ECO:0000269|PubMed:17121834}. Membrane raft {ECO:0000269|PubMed:18641330}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10713127, ECO:0000269|PubMed:18641330}. Note=Behaves as an integral membrane protein of the mitochondrion despite the absence of a detectable transmembrane domain (PubMed:21746876). Also associates with the actin cytoskeleton and membrane rafts in activated T-cells (PubMed:10713127, PubMed:18641330). A minor pool is associated with the plasma membrane and is enriched at the immunological synapse in activated T-cells (PubMed:22623988). {ECO:0000269|PubMed:10713127, ECO:0000269|PubMed:18641330, ECO:0000269|PubMed:21746876, ECO:0000269|PubMed:22623988}.
uniprot
proteins