Cops7a
entrez
26894
canonical
uniprot
Q9CZ04
canonical
ensembl
ENSMUSG00000030127
resolver
ensp
ENSMUSP00000032220
resolver
ensp
ENSMUSP00000108058
resolver
ensp
ENSMUSP00000312001
resolver
ensp
ENSMUSP00000312010
resolver
ensp
ENSMUSP00000312017
resolver
ensp
ENSMUSP00000312018
resolver
ensp
ENSMUSP00000312019
resolver
ensp
ENSMUSP00000312029
resolver
ensp
ENSMUSP00000312035
resolver
ensp
ENSMUSP00000312037
resolver
ensp
ENSMUSP00000355879
resolver
genesymbol
Cops7a
resolver
genesymbol_syn
Csn7a
resolver
uniprot
O88546
resolver
uniprot
Q925R8
resolver
uniprot
Q9CPQ4
resolver
uniprot
Q9CWD2
resolver
uniprot_entry
CSN7A_MOUSE
resolver
uniprot_sec
O88546
resolver
uniprot_sec
Q925R8
resolver
uniprot_sec
Q9CPQ4
resolver
uniprot_sec
Q9CWD2
resolver
amino_acid_sequence
MSAEVKVTGQNQEQFLLLAKSAKGAALATLIHQVLEAPGVYVFGELLDMPNVRELAESDFASTFRLLTVFAYGTYADYLAEARNLPPLTDAQKNKLRHLSVVTLAAKVKCIPYAVLLEALALRNVRQLEDLVIEAVYADVLRGSLDQRNQRLEVDYSIGRDIQRQDLSAIAQTLQEWCVGCEVVLSGIEEQVSRANQHKEQQLGLKQQIESEVANLKKTIKVTTAAAAAATSQDPEQHLTELREPASGTNQRQPSKKASKGKGLRGSAKIWSKSN
uniprot
proteins
function
FUNCTION: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
30224
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CK2 and PKD kinases.
uniprot
proteins
protein_family
CSN7 subfamily
uniprot
proteins
protein_family
CSN7/EIF3M family
uniprot
proteins
pubmed
11819679
uniprot
proteins
pubmed
15451666
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9707402
uniprot
proteins
sequence_length
275
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
uniprot
proteins