Slc48a1
entrez
300191
canonical
uniprot
B0BNL4
canonical
ensembl
ENSRNOG00000053196
resolver
ensembl
ENSRNOG00055011840
resolver
ensembl
ENSRNOG00060009127
resolver
ensembl
ENSRNOG00065017429
resolver
ensp
ENSRNOP00000077408
resolver
genesymbol
Slc48a1
resolver
genesymbol_syn
Hrg1
resolver
uniprot
Q3KR77
resolver
uniprot_entry
HRG1_RAT
resolver
uniprot_sec
Q3KR77
resolver
amino_acid_sequence
MAPTRLQLGVRAAYSGFSSLAGFSIFFVWTVVYRQPGTAAMGGLAGVLALWVLVTHVMYMQDYWRTWLRGLRGFFFVGALFSAVSFSAFCTFLTLAITQHQSFKDPNSYYLSCVWSFISFKWAFLLSLYAHRYRADFADISILSDF
uniprot
proteins
function
FUNCTION: Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment. In macrophages of the reticuloendothelial system, is the heme transporter for heme-iron recycling. Essential for macrophage iron homeostasis, transports heme from the phagolysosome to the cytoplasm during erythrophagocytosis (EP). {ECO:0000250|UniProtKB:Q6P1K1}.
uniprot
proteins
mass_dalton
16615
uniprot
proteins
protein_family
HRG family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
146
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:Q6P1K1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q6P1K1}. Lysosome membrane {ECO:0000250|UniProtKB:Q6P1K1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q6P1K1}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9D8M3}; Multi-pass membrane protein {ECO:0000255}. Note=In macrophages, specifically localizes to the phagolysosomal membranes during erythrophagocytosis. {ECO:0000250|UniProtKB:Q9D8M3}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 40..60; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 73..93; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 110..130; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins