Timp1
entrez
21857
canonical
uniprot
P12032
canonical
ensembl
ENSMUSG00000001131
resolver
ensp
ENSMUSP00000009530
resolver
ensp
ENSMUSP00000110999
resolver
ensp
ENSMUSP00000328469
resolver
enst
ENSMUST00000009530
resolver
enst
ENSMUST00000115342
resolver
genesymbol
Timp1
resolver
genesymbol_syn
Timp
resolver
genesymbol_syn
Timp-1
resolver
uniprot
P20064
resolver
uniprot
Q61720
resolver
uniprot_entry
TIMP1_MOUSE
resolver
uniprot_sec
P20064
resolver
uniprot_sec
Q61720
resolver
amino_acid_sequence
MMAPFASLASGILLLLSLIASSKACSCAPPHPQTAFCNSDLVIRAKFMGSPEINETTLYQRYKIKMTKMLKGFKAVGNAADIRYAYTPVMESLCGYAHKSQNRSEEFLITGRLRNGNLHISACSFLVPWRTLSPAQQRAFSKTYSAGCGVCTVFPCLSIPCKLESDTHCLWTDQVLVGSEDYQSRHFACLPRNPGLCTWRSLGAR
uniprot
proteins
function
FUNCTION: Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14 (By similarity). Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. {ECO:0000250, ECO:0000269|PubMed:23522389}.
uniprot
proteins
mass_dalton
22628
uniprot
proteins
post_translational_modification
PTM: The activity of TIMP1 is dependent on the presence of disulfide bonds. {ECO:0000250}.; PTM: N-glycosylated. {ECO:0000250}.
uniprot
proteins
protein_family
Protease inhibitor I35 (TIMP) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23522389
uniprot
proteins
pubmed
2744464
uniprot
proteins
pubmed
3024122
uniprot
proteins
pubmed
3034603
uniprot
proteins
pubmed
3670294
uniprot
proteins
pubmed
6179042
uniprot
proteins
sequence_length
205
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23522389}.
uniprot
proteins