CTNNA2
entrez
1496
canonical
uniprot
P26232
canonical
ensembl
ENSG00000066032
resolver
ensp
ENSP00000341500
resolver
ensp
ENSP00000355398
resolver
ensp
ENSP00000384638
resolver
ensp
ENSP00000418191
resolver
ensp
ENSP00000419295
resolver
ensp
ENSP00000444675
resolver
ensp
ENSP00000486160
resolver
genesymbol
CTNNA2
resolver
genesymbol_syn
CAPR
resolver
hgnc
HGNC:2510
resolver
uniprot
B3KXE5
resolver
uniprot
B7Z2W7
resolver
uniprot
B7Z352
resolver
uniprot
B7Z898
resolver
uniprot
F6KRI5
resolver
uniprot
Q49AD3
resolver
uniprot
Q4ZFW1
resolver
uniprot
Q53R26
resolver
uniprot
Q53R33
resolver
uniprot
Q53T67
resolver
uniprot
Q53T71
resolver
uniprot
Q53TM8
resolver
uniprot
Q7Z3L1
resolver
uniprot
Q7Z3Y0
resolver
uniprot_entry
CTNA2_HUMAN
resolver
uniprot_entry
F6KRI5_HUMAN
resolver
uniprot_entry
Q49AD3_HUMAN
resolver
uniprot_sec
B3KXE5
resolver
uniprot_sec
B7Z2W7
resolver
uniprot_sec
B7Z352
resolver
uniprot_sec
B7Z898
resolver
uniprot_sec
Q4ZFW1
resolver
uniprot_sec
Q53R26
resolver
uniprot_sec
Q53R33
resolver
uniprot_sec
Q53T67
resolver
uniprot_sec
Q53T71
resolver
uniprot_sec
Q53TM8
resolver
uniprot_sec
Q7Z3L1
resolver
uniprot_sec
Q7Z3Y0
resolver
amino_acid_sequence
MTSATSPIILKWDPKSLEIRTLTVERLLEPLVTQVTTLVNTSNKGPSGKKKGRSKKAHVLAASVEQATQNFLEKGEQIAKESQDLKEELVAAVEDVRKQGETMRIASSEFADDPCSSVKRGTMVRAARALLSAVTRLLILADMADVMRLLSHLKIVEEALEAVKNATNEQDLANRFKEFGKEMVKLNYVAARRQQELKDPHCRDEMAAARGALKKNATMLYTASQAFLRHPDVAATRANRDYVFKQVQEAIAGISNAAQATSPTDEAKGHTGIGELAAALNEFDNKIILDPMTFSEARFRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMNNTGRKEKGDPLNIAIDKMTKKTRDLRRQLRKAVMDHISDSFLETNVPLLVLIEAAKSGNEKEVKEYAQVFREHANKLVEVANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTLAARPQSKVAQDNMDVFKDQWEKQVRVLTEAVDDITSVDDFLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRAARVIHIINAEMENYEAGVYTEKVLEATKLLSETVMPRFAEQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRKAVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIAGQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVINAAKKIAEAGSRMDKLARAVADQCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELIVSGTGVQSTFTTFYEVDCDVIDGGRASQLSTHLPTCAEGAPIGSGSSDSSMLDSATSLIQAAKNLMNAVVLTVKASYVASTKYQKVYGTAAVNSPVVSWKMKAPEKKPLVKREKPEEFQTRVRRGSQKKHISPVQALSEFKAMDSF
uniprot
proteins
disease_involvement
DISEASE: Cortical dysplasia, complex, with other brain malformations 9 (CDCBM9) [MIM:618174]: An autosomal recessive disorder characterized by neurodevelopmental delay apparent from early infancy, acquired microcephaly, hypotonic cerebral palsy, inability to ambulate or speak, and intractable seizures. Brain imaging shows pachygyria with severe cortical gray matter thickening, paucity of gyri without an obvious posterior-anterior gradient or focal dysplasias, hypogenesis of the corpus callosum, and cerebellar hypoplasia. {ECO:0000269|PubMed:30013181}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed:30013181). It acts as a negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed:30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed:30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity). {ECO:0000250|UniProtKB:Q61301, ECO:0000269|PubMed:30013181}.
uniprot
proteins
mass_dalton
105313
uniprot
proteins
protein_family
Vinculin/alpha-catenin family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16182284
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18163523
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
30013181
uniprot
proteins
pubmed
8432524
uniprot
proteins
sequence_length
953
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q61301}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q61301}; Cytoplasmic side {ECO:0000250|UniProtKB:Q61301}. Cytoplasm {ECO:0000269|PubMed:16182284}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q61301}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q61301}. Cell projection, axon {ECO:0000250|UniProtKB:Q61301}. Nucleus {ECO:0000269|PubMed:16182284}.
uniprot
proteins