Q8K3V3
uniprot
Q8K3V3
canonical
activity_regulation
ACTIVITY REGULATION: Forms a heterodimer of 2 chains generated by proteolytic processing that remain associated through non-covalent interactions mediated by the GAIN-B domain. In the inactivated receptor, the Stachel sequence (also named stalk) is embedded in the GAIN-B domain, where it adopts a beta-strand conformation. On activation, the Stachel moves into the 7 transmembrane region and adopts a twisted hook-shaped configuration that forms contacts within the receptor, leading to coupling of a G-alpha protein, which activates signaling. The cleaved GAIN-B and N-terminal domains can then dissociate from the rest of the receptor. {ECO:0000250|UniProtKB:Q9Y653}.
uniprot
proteins
amino_acid_sequence
MAVQVLLQMVYFLLTLLFLVQGAHGASPREDFRFCGQRNQTQQSTLHYDQTSEPHIFVWNTDESLTIRAPFPAAPDIPYFFPEPRGLYHFCLYWSRHTGRLHLRYGKNDYLLSSRASNLLCYRKQEESLKQGAPLVATSVSSWQSPQNTSLPGAPSFIFSFHNAPHKVSHNASVNMCDLKKELQLLSKFLQHPHKASKRPSAAFISQQLQNLESKLTSVSFLGDTLSFEENRVNATVWKLPPTAGLEDLQIHSQQEEEQSEVQAYSVLLPRAVFQQTRGRRRDAAKRLLVVDFSSQALFQDKNSSQVLGEKVLGIVVQNTKVTNLSDPVVLTFQHQPQPKNVTLQCVFWVEDPASSSTGSWSSEGCETVSRDTQTSCLCNHLTYFAVLMVSSMEVEATHKHYLTLLSYVGCVISALACVFTIAAYLCTRRKSRDYTIKVHMNLLLAVFLLDVSFLLSEPVALMGSEAACRTSAMFLHFSLLACLSWMGLEGYNLYRLVVEVFGTYVPGYLLKLSTVGWGFPVFLVTLVALVDVNNYGPIILAVRRTPDHVIYPSMCWIRDSVVSYVTNLGLFSLVFLFNMAMLATMVVQILRLRPHSQKWPHVLTLLGLSLVLGLPWALVFFSFASGTFQLVIIYLFSIMTSFQGFLIFLWYWSMRFQAQGGPSPLKNNSDSAKLPISSGSTSSSRI
uniprot
proteins
function
FUNCTION: Adhesion G protein-coupled receptor (aGPCR) for steroid hormone 17alpha-hydroxypregnenolone (17-OH), which is involved in cell adhesion and cell-cell interactions. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as RhoA pathway. ADGRG1 is coupled to G(12) and/or G(13) G proteins (GNA12 and GNA13, respectively) and mediates the activation Rho small GTPases (By similarity). Acts as a potent suppressor of ferroptosis: binding to 17-OH-binding initiates signaling that down-regulates CD36 and alleviates ferroptosis-induced liver injury. Ligand-binding also induces cell adhesion activity via association with proteins such as collagen III/COL3A1 and TGM2. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells (By similarity). Involved in cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination: association with COL3A1 in the developing brain inhibits neuronal migration via activation of the RhoA pathway (By similarity). Together with TGM2, acts as a regulator of myelination and myelin repair in oligodendrocyte precursor cells (By similarity). Acts as a hemostatic sensor of shear force: G protein-coupled receptor signaling is activated in response to shear force in platelets, promoting G(13) G protein signaling, and platelet shape change and aggregation in a COL3A1-dependent manner. Acts as an inhibitor of VEGFA production thereby inhibiting angiogenesis through a signaling pathway mediated by PRKCA (By similarity). Plays a role in the maintenance of hematopoietic stem cells in bone marrow niche. Plays an essential role in testis development (By similarity). {ECO:0000250|UniProtKB:Q8K209, ECO:0000250|UniProtKB:Q9Y653}.
uniprot
proteins
mass_dalton
77252
uniprot
proteins
post_translational_modification
PTM: Autoproteolytically cleaved into 2 fragments; the large extracellular N-terminal fragment and the membrane-bound C-terminal fragment predominantly remain associated and non-covalently linked. Shedding to yield the secreted ADGRG1 N-terminal fragment also seems to involve metalloprotease(s). {ECO:0000269|PubMed:21708946}.; PTM: Ubiquitinated. Undergoes polyubiquitination upon activation. {ECO:0000250|UniProtKB:Q9Y653}.
uniprot
proteins
protein_family
G protein-coupled receptor 2 family
uniprot
proteins
protein_family
LN-TM7 subfamily
uniprot
proteins
pubmed
21708946
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
687
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9Y653}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9Y653}.; SUBCELLULAR LOCATION: [Adhesion G protein-coupled receptor G1, N-terminal fragment]: Secreted {ECO:0000250|UniProtKB:Q9Y653}. Note=Activation of the G protein-coupled receptor and interaction with COL3A1 leads to the release of ADGRG1 NT from the membrane. {ECO:0000250|UniProtKB:Q9Y653}.; SUBCELLULAR LOCATION: [Adhesion G protein-coupled receptor G1, C-terminal fragment]: Membrane raft {ECO:0000250|UniProtKB:Q9Y653}. Note=Interaction with its ligand COL3A1 leads to the release of ADGRG1 NT from the membrane and triggers the association of ADGRG1 CT with lipid rafts. {ECO:0000250|UniProtKB:Q9Y653}.
uniprot
proteins
transmembrane_region
TRANSMEM 403..423; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 443..463; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 472..492; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 513..533; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 571..591; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 604..624; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 631..651; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins