Tex19.1
entrez
73679
canonical
uniprot
Q99MV2
canonical
ensembl
ENSMUSG00000039329
resolver
ensp
ENSMUSP00000048592
resolver
enst
ENSMUST00000039088
resolver
genesymbol
Tex19.1
resolver
genesymbol_syn
Tex19
resolver
genesymbol_syn
Tex19a
resolver
uniprot
Q7TPF0
resolver
uniprot_entry
TX19A_MOUSE
resolver
uniprot_sec
Q7TPF0
resolver
amino_acid_sequence
MCPPVSVRHGARGMSCLYEAWLYHLVHGEQTKICFACFKAAFLLNKLYLEMGDWQEEEEEEEEEDADLLEYLSESESESEQEPGPEQDAWRGLGSLYVPQSVSEGSGVLLPTPVWTQGILFSIFVPTELFPQEAVPLDLGPEDAEWTQALPWRLDGLFPCSHQLIPPLTWWDIFDVMPSPGQPVLLELRCHWPLDQTVAQSWLQDQKFVLLLDSVQSRCHLLSMRVRWVVRTQVQHWQVLLDPGEMWVAHFRKEVGQHGLYHQSLNPWRLSILTASELGMELLPATCYLWNKGFWVGSFLPWHINMPETWSWEPGERLFITDATICGTDYHLAQSFLDSHPTPHPLLTLTP
uniprot
proteins
function
FUNCTION: Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and preventing their mobilization (PubMed:18802469, PubMed:21103378, PubMed:23364048, PubMed:23674551, PubMed:28254886). With its paralog, Tex19.2, collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements (PubMed:28254886). Also during spermatogenesis, promotes, with UBR2, SPO11-dependent meiotic recombination (PubMed:28708824). Interacts with LINE-1 retrotransposon encoded LIRE1, stimulates LIRE1 polyubiquitination, mediated by UBR2, and degradation, inhibiting LINE-1 retrotransposon mobilization (PubMed:28806172). {ECO:0000269|PubMed:18802469, ECO:0000269|PubMed:21103378, ECO:0000269|PubMed:23364048, ECO:0000269|PubMed:23674551, ECO:0000269|PubMed:28254886, ECO:0000269|PubMed:28708824, ECO:0000269|PubMed:28806172}.
uniprot
proteins
mass_dalton
40401
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="C->G,V: Does not affect interaction with UBR2."; /evidence="ECO:0000269|PubMed:21103378
uniprot
proteins
pubmed
11279525
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18096721
uniprot
proteins
pubmed
18802469
uniprot
proteins
pubmed
19247806
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21103378
uniprot
proteins
pubmed
22447323
uniprot
proteins
pubmed
23364048
uniprot
proteins
pubmed
23674551
uniprot
proteins
pubmed
28254886
uniprot
proteins
pubmed
28708824
uniprot
proteins
pubmed
28806172
uniprot
proteins
sequence_length
351
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18802469}. Note=Was initially reported to localize in the nucleus (PubMed:18096721). However, it was later shown to localize in cytoplasm only (PubMed:18802469). Cytoplasmic localization is distinct from the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis (PubMed:18802469). {ECO:0000269|PubMed:18096721, ECO:0000269|PubMed:18802469}.
uniprot
proteins