Scn2b
entrez
25349
canonical
uniprot
P54900
canonical
ensembl
ENSRNOG00000063505
resolver
ensembl
ENSRNOG00055001943
resolver
ensembl
ENSRNOG00055019794
resolver
ensembl
ENSRNOG00060019060
resolver
ensembl
ENSRNOG00065024380
resolver
ensp
ENSRNOP00000078627
resolver
ensp
ENSRNOP00055002342
resolver
ensp
ENSRNOP00055027452
resolver
ensp
ENSRNOP00060026944
resolver
ensp
ENSRNOP00065034163
resolver
enst
ENSRNOT00000106113
resolver
enst
ENSRNOT00055003113
resolver
enst
ENSRNOT00055033806
resolver
enst
ENSRNOT00060032947
resolver
enst
ENSRNOT00065041799
resolver
genesymbol
Scn2b
resolver
uniprot_entry
SCN2B_RAT
resolver
amino_acid_sequence
MHRDAWLPRPAFSLTGLSLFFSLVPSGRSMEVTVPTTLSVLNGSDTRLPCTFNSCYTVNHKQFSLNWTYQECSNCSEEMFLQFRMKIINLKLERFGDRVEFSGNPSKYDVSVTLKNVQLEDEGIYNCYITNPPDRHRGHGKIYLQVLLEVPPERDSTVAVIVGASVGGFLAVVILVLMVVKCVRRKKEQKLSTDDLKTEEEGKTDGEGNAEDGAK
uniprot
proteins
function
FUNCTION: Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:15178439, PubMed:22992729, PubMed:26894959). The accessory beta subunits participate in localization and functional modulation of the Nav channels (PubMed:15178439, PubMed:22992729, PubMed:26894959). Modulates the activity of SCN1A/Nav1.1, SCN2A/Nav1.2, SCN2A/Nav1.3, SCN5A/Nav1.5, SCN8A/Nav1.6, SCN9A/Nav1.7 and SCN10A/Nav1.8 (By similarity) (PubMed:15178439, PubMed:22992729, PubMed:26894959). {ECO:0000250|UniProtKB:O60939, ECO:0000269|PubMed:15178439, ECO:0000269|PubMed:22992729, ECO:0000269|PubMed:26894959}.
uniprot
proteins
mass_dalton
24145
uniprot
proteins
mutagenesis
MUTAGEN 55; /note="C->A: Loss of disulfide linkage with alpha subunit. No effect on localization to the plasma membrane. Loss of localization to node of Ranvier."; /evidence="ECO:0000269|PubMed:22992729
uniprot
proteins
protein_family
Sodium channel auxiliary subunit SCN2B (TC 8.A.17) family
uniprot
proteins
pubmed
15178439
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
22992729
uniprot
proteins
pubmed
26894959
uniprot
proteins
pubmed
8521473
uniprot
proteins
pubmed
9861042
uniprot
proteins
sequence_length
215
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22992729}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O60939}. Cell projection, axon {ECO:0000269|PubMed:22992729}. Note=Clusters at the axon initial segment and node of Ranvier, the specialized neuronal subcellular domains involved in action potentials generation and propagation. {ECO:0000269|PubMed:22992729}.
uniprot
proteins
transmembrane_region
TRANSMEM 158..179; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O60939
uniprot
proteins