Tnfrsf21
entrez
316256
canonical
uniprot
D3ZF92
canonical
ensembl
ENSRNOG00000011517
resolver
ensembl
ENSRNOG00055020124
resolver
ensembl
ENSRNOG00060021980
resolver
ensembl
ENSRNOG00065025203
resolver
ensp
ENSRNOP00000015918
resolver
ensp
ENSRNOP00055027825
resolver
ensp
ENSRNOP00060031376
resolver
ensp
ENSRNOP00065035587
resolver
enst
ENSRNOT00000015918
resolver
enst
ENSRNOT00055034353
resolver
enst
ENSRNOT00060038073
resolver
enst
ENSRNOT00065043392
resolver
genesymbol
Tnfrsf21
resolver
genesymbol_syn
Dr6
resolver
uniprot_entry
TNR21_RAT
resolver
amino_acid_sequence
MGTSASSITALASCSRIAGQVGATMVAGSLLLLGFLSTITAQPEQKTLSLTGTYRHVDRTTGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPSGTFTRHENGIERCHDCSQPCPRPMIERLPCAALTDRECICPPGMYQSNGTCAPHTVCPVGWGVRKKGTENEDVRCKQCARGTFSDVPSSVMKCRAHTDCLGQNLMVVKQGTKETDNVCGVHLSSSSTTPSSPGIATFSHPEHTESHDVPSSTYEPQGMNSTDSNSTASVRTKVPSDIQEETVPDNTSSTSGKESTNRTLPNPPQLTHQQGPHHRHILKLLPSSMEATGEKSSTAIKAPKRGHPRQNPHKHFDINEHLPWMIVLFLLLVLVLIVVCSIRKSSRTLKKGPRQDPSAIMEKAGLKKSLTPTQNREKWIYYRNGHGIDILKLVAAQVGSQWKDIYQFLCNASEREVAAFSNGYTADHERAYAALQHWTIRGPEASLAQLISALRQHRRNDVVEKIRGLMEDTTQLETDKLALPMSPSPLSPSPIPSPNVKLENSTLLTVEPSPLDKNKGFFVDESEPLLRCDSTSSGSSALSRNGSFITKEKKDTVLRQVRLDPCDLQPIFDDMLHILNPEELRVIEEIPQAEDKLDRLFEIIGVKSQEASQTLLDSVYSHLPDLL
uniprot
proteins
function
FUNCTION: Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B (By similarity). Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm (By similarity). Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP) (By similarity). Negatively regulates oligodendrocyte survival, maturation and myelination (PubMed:21725297). Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation (By similarity). Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells (By similarity). Negatively regulates the production of IgG, IgM and IgM in response to antigens (By similarity). May inhibit the activation of JNK in response to T-cell stimulation (By similarity). Also acts as a regulator of pyroptosis: recruits CASP8 in response to reactive oxygen species (ROS) and subsequent oxidation, leading to activation of GSDMC (By similarity). {ECO:0000250|UniProtKB:O75509, ECO:0000269|PubMed:21725297}.
uniprot
proteins
mass_dalton
71870
uniprot
proteins
post_translational_modification
PTM: Oxidized in response to reactive oxygen species (ROS), leading to endocytosis. {ECO:0000250|UniProtKB:O75509}.
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
21725297
uniprot
proteins
sequence_length
655
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O75509}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O75509}. Note=Endocytosed following oxidation in response to reactive oxygen species (ROS). {ECO:0000250|UniProtKB:O75509}.
uniprot
proteins
transmembrane_region
TRANSMEM 350..370; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins