Taf1
entrez
270627
canonical
uniprot
Q80UV9
canonical
ensembl
ENSMUSG00000031314
resolver
ensp
ENSMUSP00000114765
resolver
ensp
ENSMUSP00000160012
resolver
ensp
ENSMUSP00000296787
resolver
ensp
ENSMUSP00000296789
resolver
enst
ENSMUST00000149274
resolver
enst
ENSMUST00000249914
resolver
genesymbol
Taf1
resolver
genesymbol_syn
Ccg1
resolver
genesymbol_syn
N-TAF1
resolver
uniprot
A0A067XG50
resolver
uniprot
A0AAQ4VMV6
resolver
uniprot
A0ACM8QFG5
resolver
uniprot
A2AM32
resolver
uniprot
A2AM33
resolver
uniprot
B1Q2W7
resolver
uniprot
O35361
resolver
uniprot
Q3UPF3
resolver
uniprot
Q3V223
resolver
uniprot
Q505F9
resolver
uniprot
Q8BQH8
resolver
uniprot
Q8BQQ7
resolver
uniprot
Q8BR59
resolver
uniprot
Q8C7N8
resolver
uniprot
Q9WTW9
resolver
uniprot
Q9WTX0
resolver
uniprot
Q9WTX1
resolver
uniprot_entry
A0AAQ4VMV6_MOUSE
resolver
uniprot_entry
A0ACM8QFG5_MOUSE
resolver
uniprot_entry
B1Q2W7_MOUSE
resolver
uniprot_entry
TAF1_MOUSE
resolver
uniprot_sec
A0A067XG50
resolver
uniprot_sec
A2AM32
resolver
uniprot_sec
A2AM33
resolver
uniprot_sec
O35361
resolver
uniprot_sec
Q3UPF3
resolver
uniprot_sec
Q3V223
resolver
uniprot_sec
Q505F9
resolver
uniprot_sec
Q8BQH8
resolver
uniprot_sec
Q8BQQ7
resolver
uniprot_sec
Q8BR59
resolver
uniprot_sec
Q8C7N8
resolver
uniprot_sec
Q9WTW9
resolver
uniprot_sec
Q9WTX0
resolver
uniprot_sec
Q9WTX1
resolver
activity_regulation
ACTIVITY REGULATION: Autophosphorylates on Ser residues. Inhibited by retinoblastoma tumor suppressor protein, RB1. Binding to TAF1 or CIITA inhibits the histone acetyltransferase activity. {ECO:0000250|UniProtKB:P21675}.
uniprot
proteins
amino_acid_sequence
MGPGWAGLLQDKGGGSPSVVMSDTDSDEESAGGGPFSLTGFLFGNINGAGQLEGESVLDDECKKHLAGLGALGLGSLITELTANEELSGSDGALVNDEGWIRSREDAVDYSDINEVAEDESRRYQQTMGSLQPLCHTDYDEDDYDADCEDIDCKLMPPPPPPPGPLKKEKDQDDITGVSEDGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQDAAQSESKDGQLTLPLAGIMQHDATKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEGQVQEEECSVELEVNQKSLWNYDYAPPPLPDQCLSDDEITMMAPVESKFSQSTGDTDKVMDTKPRVAEWRYGPARLWYDMLGVPEDGSGFDYGFKMKKTEHESTIKCNIMKKLRKLEENSGVDLLADENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFTATLDDDKPWYSIFPIDNEDLVYGRWEDNIIWDAQNMPRILEPPVLTLDPNDENLILEIPDEKEEATSNSPSKENKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQGLRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPESDFLIIRTRQGYFIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAMVSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFIAAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSREREEQERKELQRMLLAAGSAAAGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEYVRCETVRKATVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQEKEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQEEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKVIVSPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNVCHQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDNNTSLSVSRDASVYQDESNLSVLDIPSATSEKQLTQEGGDGDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFFAIQLSESGSDSDVESGSLRPKQPRVLQENTRMGMENEESMMSYEGDGGDASRGLEDSNISYGSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEQRSGPSVLSQVHLSEDEEDSEDFHSIAGDTDLDSDE
uniprot
proteins
ec_number
2.3.1.48
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (By similarity). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (By similarity). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (By similarity). TAF1 is the largest component and core scaffold of the TFIID complex, involved in nucleating complex assembly (PubMed:10438527). TAF1 forms a promoter DNA binding subcomplex of TFIID, together with TAF7 and TAF2 (By similarity). Contains novel N- and C-terminal Ser/Thr kinase domains which can autophosphorylate or transphosphorylate other transcription factors (By similarity). Phosphorylates TP53 on 'Thr-55' which leads to MDM2-mediated degradation of TP53 (By similarity). Phosphorylates GTF2A1 and GTF2F1 on Ser residues (By similarity). Possesses DNA-binding activity (By similarity). Exhibits histone acetyltransferase activity towards histones H3 and H4 (By similarity). Essential for progression of the G1 phase of the cell cycle (By similarity). {ECO:0000250|UniProtKB:P21675, ECO:0000269|PubMed:10438527}.
uniprot
proteins
mass_dalton
214419
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by casein kinase II in vitro. {ECO:0000250|UniProtKB:P21675}.
uniprot
proteins
protein_family
TAF1 family
uniprot
proteins
pubmed
10070062
uniprot
proteins
pubmed
10438527
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
9751712
uniprot
proteins
sequence_length
1891
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P21675}.
uniprot
proteins