DMAP1
entrez
55929
canonical
uniprot
Q9NPF5
canonical
ensembl
ENSG00000178028
resolver
ensp
ENSP00000312697
resolver
ensp
ENSP00000354697
resolver
ensp
ENSP00000361363
resolver
enst
ENST00000315913
resolver
enst
ENST00000361745
resolver
enst
ENST00000372289
resolver
genesymbol
DMAP1
resolver
genesymbol_syn
KIAA1425
resolver
hgnc
HGNC:18291
resolver
uniprot
A8K001
resolver
uniprot
D3DPY8
resolver
uniprot
Q0JSM4
resolver
uniprot
Q5TG41
resolver
uniprot
Q7Z3H7
resolver
uniprot
Q9H0S8
resolver
uniprot
Q9P2C2
resolver
uniprot_entry
DMAP1_HUMAN
resolver
uniprot_sec
A8K001
resolver
uniprot_sec
D3DPY8
resolver
uniprot_sec
Q0JSM4
resolver
uniprot_sec
Q5TG41
resolver
uniprot_sec
Q7Z3H7
resolver
uniprot_sec
Q9H0S8
resolver
uniprot_sec
Q9P2C2
resolver
amino_acid_sequence
MATGADVRDILELGGPEGDAASGTISKKDIINPDKKKSKKSSETLTFKRPEGMHREVYALLYSDKKDAPPLLPSDTGQGYRTVKAKLGSKKVRPWKWMPFTNPARKDGAMFFHWRRAAEEGKDYPFARFNKTVQVPVYSEQEYQLYLHDDAWTKAETDHLFDLSRRFDLRFVVIHDRYDHQQFKKRSVEDLKERYYHICAKLANVRAVPGTDLKIPVFDAGHERRRKEQLERLYNRTPEQVAEEEYLLQELRKIEARKKEREKRSQDLQKLITAADTTAEQRRTERKAPKKKLPQKKEAEKPAVPETAGIKFPDFKSAGVTLRSQRMKLPSSVGQKKIKALEQMLLELGVELSPTPTEELVHMFNELRSDLVLLYELKQACANCEYELQMLRHRHEALARAGVLGGPATPASGPGPASAEPAVTEPGLGPDPKDTIIDVVGAPLTPNSRKRRESASSSSSVKKAKKP
uniprot
proteins
function
FUNCTION: Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity. {ECO:0000269|PubMed:14665632, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:14978102, ECO:0000269|PubMed:15367675}.
uniprot
proteins
mass_dalton
52993
uniprot
proteins
pubmed
10718198
uniprot
proteins
pubmed
10888872
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12963728
uniprot
proteins
pubmed
14665632
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14966270
uniprot
proteins
pubmed
14978102
uniprot
proteins
pubmed
15196461
uniprot
proteins
pubmed
15367675
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
467
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Targeted to replication foci throughout S phase by DNMT1.
uniprot
proteins