Mgat3
entrez
29582
canonical
uniprot
Q02527
canonical
ensembl
ENSRNOG00000017434
resolver
ensembl
ENSRNOG00055029609
resolver
ensembl
ENSRNOG00060031561
resolver
ensembl
ENSRNOG00065033353
resolver
ensp
ENSRNOP00000023434
resolver
ensp
ENSRNOP00000076485
resolver
ensp
ENSRNOP00000076545
resolver
ensp
ENSRNOP00000077338
resolver
ensp
ENSRNOP00000080479
resolver
ensp
ENSRNOP00000082287
resolver
ensp
ENSRNOP00000082492
resolver
ensp
ENSRNOP00000086583
resolver
ensp
ENSRNOP00000093292
resolver
ensp
ENSRNOP00000097179
resolver
ensp
ENSRNOP00055042228
resolver
ensp
ENSRNOP00055042232
resolver
ensp
ENSRNOP00055042235
resolver
ensp
ENSRNOP00055042237
resolver
ensp
ENSRNOP00055042240
resolver
ensp
ENSRNOP00055042246
resolver
ensp
ENSRNOP00055042254
resolver
ensp
ENSRNOP00055042255
resolver
ensp
ENSRNOP00055042260
resolver
ensp
ENSRNOP00055042264
resolver
ensp
ENSRNOP00060045215
resolver
ensp
ENSRNOP00060045220
resolver
ensp
ENSRNOP00060045226
resolver
ensp
ENSRNOP00060045228
resolver
ensp
ENSRNOP00060045230
resolver
ensp
ENSRNOP00060045233
resolver
ensp
ENSRNOP00060045238
resolver
ensp
ENSRNOP00060045241
resolver
ensp
ENSRNOP00060045244
resolver
ensp
ENSRNOP00060045248
resolver
ensp
ENSRNOP00065047176
resolver
ensp
ENSRNOP00065047177
resolver
ensp
ENSRNOP00065047181
resolver
ensp
ENSRNOP00065047183
resolver
ensp
ENSRNOP00065047185
resolver
ensp
ENSRNOP00065047187
resolver
ensp
ENSRNOP00065047190
resolver
ensp
ENSRNOP00065047193
resolver
ensp
ENSRNOP00065047194
resolver
ensp
ENSRNOP00065047196
resolver
enst
ENSRNOT00000023434
resolver
enst
ENSRNOT00000095447
resolver
enst
ENSRNOT00000097844
resolver
enst
ENSRNOT00000098313
resolver
enst
ENSRNOT00000103460
resolver
enst
ENSRNOT00000105515
resolver
enst
ENSRNOT00000109650
resolver
enst
ENSRNOT00000113053
resolver
enst
ENSRNOT00000117804
resolver
enst
ENSRNOT00000117832
resolver
enst
ENSRNOT00055051259
resolver
enst
ENSRNOT00055051263
resolver
enst
ENSRNOT00055051266
resolver
enst
ENSRNOT00055051269
resolver
enst
ENSRNOT00055051272
resolver
enst
ENSRNOT00055051277
resolver
enst
ENSRNOT00055051286
resolver
enst
ENSRNOT00055051289
resolver
enst
ENSRNOT00055051292
resolver
enst
ENSRNOT00055051296
resolver
enst
ENSRNOT00060054680
resolver
enst
ENSRNOT00060054685
resolver
enst
ENSRNOT00060054691
resolver
enst
ENSRNOT00060054693
resolver
enst
ENSRNOT00060054695
resolver
enst
ENSRNOT00060054698
resolver
enst
ENSRNOT00060054703
resolver
enst
ENSRNOT00060054706
resolver
enst
ENSRNOT00060054709
resolver
enst
ENSRNOT00060054713
resolver
enst
ENSRNOT00065057335
resolver
enst
ENSRNOT00065057336
resolver
enst
ENSRNOT00065057340
resolver
enst
ENSRNOT00065057342
resolver
enst
ENSRNOT00065057344
resolver
enst
ENSRNOT00065057346
resolver
enst
ENSRNOT00065057349
resolver
enst
ENSRNOT00065057352
resolver
enst
ENSRNOT00065057353
resolver
enst
ENSRNOT00065057355
resolver
genesymbol
Mgat3
resolver
genesymbol_syn
Gnt3
resolver
uniprot_entry
MGAT3_RAT
resolver
amino_acid_sequence
MKMRRYKLFLMFCMAGLCLISFLHFFKTLSYVTFPRELASLSPNLISSFFWNNAPVTPQASPEPGDPDLLRTPLYSHSPLLQPLSPSKATEELHRVDFVLPEDTTEYFVRTKAGGVCFKPGTRMLEKPSPGRTEEKTKVAEGSSVRGPARRPMRHVLSARERLGGRGTRRKWVECVCLPGWHGPSCGVPTVVQYSNLPTKERLVPREVPRRVINAININHEFDLLDVRFHELGDVVDAFVVCESNFTAYGEPRPLKFREMLTNGTFEYIRHKVLYVFLDHFPPGGRQDGWIADDYLRTFLTQDGVSRLRNLRPDDVFIIDDADEIPARDGVLFLKLYDGWTEPFAFHMRKSLYGFFWKQPGTLEVVSGCTIDMLQAVYGLDGIRLRRRQYYTMPNFRQYENRTGHILVQWSLGSPLHFAGWHCSWCFTPEGIYFKLVSAQNGDFPRWGDYEDKRDLNYIRSLIRTGGWFDGTQQEYPPADPSEHMYAPKYLLKNYDQFRYLLENPYREPKSTVEGGRRNQGSDGRSSAVRGKLDTTEG
uniprot
proteins
ec_number
2.4.1.144
uniprot
proteins
function
FUNCTION: It is involved in the regulation of the biosynthesis and biological function of glycoprotein oligosaccharides. Catalyzes the addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains, called bisecting N-acetylglucosamine (GlcNAc). It is one of the most important enzymes involved in the regulation of the biosynthesis of glycoprotein oligosaccharides. The addition of this bisecting GlcNAc residue alters not only the composition, but also the conformation of the N-glycan. The introduction of the bisecting GlcNAc residue results in the suppression of further processing and elongation of N-glycans, precluding the formation of beta-1,6 GlcNAc branching, catalyzed by MGAT5 since it is unable to use the bisected oligosaccharide as a substrate. Addition of bisecting N-acetylglucosamine to CDH1/E-cadherin modulates CDH1 cell membrane location. Inhibits NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc- formation which modulates sialylation levels and plays a role in cell migration regulation (By similarity). In brain, addition of bisecting N-acetylglucosamine to BACE1 blocks its lysosomal targeting in response to oxidative stress and further degradation which increases its location to early endosome and the APP cleavage (By similarity). Adds bisecting GlcNAc residue to complex-type N-linked-glycans attached on fragment crystallizable (Fc) of IgGs. Readily converts fucosylated and non-fucosylated core glycoforms with terminal GlcNAcs on both antennae. Prior galactosylation of GlcNAc on the alpha(1->3) Man branch prevents N-glycan bisection, whereas galactosylation of GlcNAc on the alpha(1->6) Man branch is permissive. {ECO:0000250|UniProtKB:Q09327, ECO:0000250|UniProtKB:Q10470}.
uniprot
proteins
mass_dalton
62022
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:Q09327}.
uniprot
proteins
protein_family
Glycosyltransferase 17 family
uniprot
proteins
pubmed
1325461
uniprot
proteins
sequence_length
538
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q09327}; Single-pass type II membrane protein {ECO:0000255}. Note=Colocalizes with ST6GAL1 and B4GALT1 in the Golgi stacks of cisternae, including the cis-part of the Golgi stacks. {ECO:0000250|UniProtKB:Q09327}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..23; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins