COPS4
entrez
51138
canonical
uniprot
Q9BT78
canonical
ensembl
ENSG00000138663
resolver
ensp
ENSP00000264389
resolver
ensp
ENSP00000424655
resolver
ensp
ENSP00000425976
resolver
enst
ENST00000511653
resolver
genesymbol
COPS4
resolver
genesymbol_syn
CSN4
resolver
hgnc
HGNC:16702
resolver
uniprot
A0A0S2Z5H7
resolver
uniprot
A0A0S2Z667
resolver
uniprot
B3KM48
resolver
uniprot
B3KN88
resolver
uniprot
B3KST5
resolver
uniprot
D6RAX7
resolver
uniprot
Q561W7
resolver
uniprot
Q9NW31
resolver
uniprot
Q9Y677
resolver
uniprot_entry
A0A0S2Z5H7_HUMAN
resolver
uniprot_entry
A0A0S2Z667_HUMAN
resolver
uniprot_entry
B3KM48_HUMAN
resolver
uniprot_entry
CSN4_HUMAN
resolver
uniprot_entry
D6RAX7_HUMAN
resolver
uniprot_sec
B3KN88
resolver
uniprot_sec
B3KST5
resolver
uniprot_sec
Q561W7
resolver
uniprot_sec
Q9NW31
resolver
uniprot_sec
Q9Y677
resolver
amino_acid_sequence
MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGAEQLEALKAFVEAMVNENVSLVISRQLLTDFCTHLPNLPDSTAKEIYHFTLEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKATTADGSSILDRAVIEHNLLSASKLYNNITFEELGALLEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHFETREALPTWDKQIQSLCFQVNNLLEKISQTAPEWTAQAMEAQMAQ
uniprot
proteins
function
FUNCTION: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. Also involved in the deneddylation of non-cullin subunits such as STON2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:21102408, ECO:0000269|PubMed:9535219}.
uniprot
proteins
mass_dalton
46269
uniprot
proteins
protein_family
CSN4 family
uniprot
proteins
pubmed
11285227
uniprot
proteins
pubmed
11337588
uniprot
proteins
pubmed
11824616
uniprot
proteins
pubmed
12628923
uniprot
proteins
pubmed
12732143
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18850735
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21102408
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26030138
uniprot
proteins
pubmed
26456823
uniprot
proteins
pubmed
9535219
uniprot
proteins
sequence_length
406
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000269|PubMed:21102408}.
uniprot
proteins