NDFIP2
entrez
54602
canonical
uniprot
Q9NV92
canonical
ensembl
ENSG00000102471
resolver
ensp
ENSP00000218652
resolver
ensp
ENSP00000419200
resolver
enst
ENST00000218652
resolver
enst
ENST00000487865
resolver
genesymbol
NDFIP2
resolver
genesymbol_syn
KIAA1165
resolver
genesymbol_syn
N4WBP5A
resolver
hgnc
HGNC:18537
resolver
uniprot
A0ACM8QGB0
resolver
uniprot
B4DGY6
resolver
uniprot
H0Y8A7
resolver
uniprot
Q7Z2H3
resolver
uniprot
Q7Z428
resolver
uniprot
Q8TAR3
resolver
uniprot
Q9ULQ5
resolver
uniprot_entry
A0ACM8QGB0_HUMAN
resolver
uniprot_entry
B4DGY6_HUMAN
resolver
uniprot_entry
NFIP2_HUMAN
resolver
uniprot_sec
H0Y8A7
resolver
uniprot_sec
Q7Z2H3
resolver
uniprot_sec
Q7Z428
resolver
uniprot_sec
Q8TAR3
resolver
uniprot_sec
Q9ULQ5
resolver
amino_acid_sequence
MARRRSQRVCASGPSMLNSARGAPELLRGTATNAEVSAAAAGATGSEELPPGDRGCRNGGGRGPAATTSSTGVAVGAEHGEDSLSRKPDPEPGRMDHHQPGTGRYQVLLNEEDNSESSAIEQPPTSNPAPQIVQAASSAPALETDSSPPPYSSITVEVPTTSDTEVYGEFYPVPPPYSVATSLPTYDEAEKAKAAAMAAAAAETSQRIQEEECPPRDDFSDADQLRVGNDGIFMLAFFMAFIFNWLGFCLSFCITNTIAGRYGAICGFGLSLIKWILIVRFSDYFTGYFNGQYWLWWIFLVLGLLLFFRGFVNYLKVRNMSESMAAAHRTRYFFLL
uniprot
proteins
function
FUNCTION: Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation (PubMed:26363003). May modulate EGFR signaling. Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (By similarity). {ECO:0000250|UniProtKB:Q91ZP6, ECO:0000269|PubMed:12761501, ECO:0000269|PubMed:19343052, ECO:0000269|PubMed:20534535, ECO:0000269|PubMed:26363003}.
uniprot
proteins
mass_dalton
36390
uniprot
proteins
mutagenesis
MUTAGEN 150..151; /note="PY->AG: Loss of E3 ubiquitin-protein ligase activation; when associated with 175-P--G-177 and 184-P--G-186. Greatly decreases NEDD4-binding; when associated with 175-P--G-177 and 184-P--G-186. No effect on PTEN-binding; when associated with 175-P--G-177 and 184-P--G-186."; MUTAGEN 167; /note="Y->F: Loss of NDFIP2 phosphorylation by SRC."; /evidence="ECO:0000269|PubMed:20534535"; MUTAGEN 176..177; /note="PY->AG: Loss of E3 ubiquitin-protein ligase activation; when associated with 149-P--G-151 and 184-P--G-186. Greatly decreases NEDD4-binding; when associated with 149-P-G-151 and 184-P--G-186. No effect on PTEN-binding; when associated with 149-P--G-151 and 184-P--G-186."; MUTAGEN 185..186; /note="TY->AG: Loss of E3 ubiquitin-protein ligase activation; when associated with 149-P--G-151 and 175-P--G-177. Greatly decreases NEDD4-binding; when associated with 149-P--G-151 and 175-P--G-177. No effect on PTEN-binding; when associated with 149-P--G-151 and 175-P--G-177.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by NEDD4 and ITCH. Also ubiquitinated by NEDD4L. Ubiquitination by NEDD4 or NEDD4L does not affect turnover (By similarity). {ECO:0000250}.; PTM: Undergoes transient tyrosine-phosphorylation following EGF stimulation, most probably catalyzed by SRC. Phosphorylation on Tyr-151, Tyr-171 and Tyr-177 are dependent on the phosphorylation on Tyr-167. Also phosphorylated by LYN and FYN. {ECO:0000269|PubMed:20534535}.
uniprot
proteins
pubmed
10574461
uniprot
proteins
pubmed
12761501
uniprot
proteins
pubmed
12796489
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18776082
uniprot
proteins
pubmed
19343052
uniprot
proteins
pubmed
20534535
uniprot
proteins
pubmed
26363003
uniprot
proteins
sequence_length
336
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:18776082}; Multi-pass membrane protein {ECO:0000269|PubMed:18776082}. Golgi apparatus membrane {ECO:0000269|PubMed:12796489, ECO:0000269|PubMed:26363003}. Endosome, multivesicular body membrane {ECO:0000269|PubMed:26363003}.
uniprot
proteins
transmembrane_region
TRANSMEM 232..252; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 258..278; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 288..308; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins