C1rb
entrez
667277
canonical
uniprot
Q8CFG9
canonical
ensembl
ENSMUSG00000098470
resolver
ensp
ENSMUSP00000139376
resolver
enst
ENSMUST00000184647
resolver
genesymbol
C1rb
resolver
genesymbol_syn
C1r
resolver
uniprot_entry
C1RB_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Activated by the C1Q subcomplex of the C1 complex following C1Q binding to immunoglobulins (IgG or IgM) complexed with antigens to form antigen-antibody complexes on the surface of pathogens. Immunoglobulin-binding promotes autoactivation of C1R, which results in the cleavage of the Arg-Ile bond in the catalytic domain. {ECO:0000250|UniProtKB:P00736}.
uniprot
proteins
amino_acid_sequence
MWLFALLVTLFYGVEGSIYLPQKLYGEVTSPLYPKPYPSDLETTTVITVPMGYRVKLVFWQFDVEPSEGCLYDYVKISADKQTLGRFCGQLDSPLGNPPGSKEFMSQGNKMLLTFHTDFSNEENGTIMFYKGFLAYYQAVDLDECASQPNSVEEGLQPRCQHLCHNYVGGYFCSCHPGYELQKDGQSCQAECSSELYTEPSGYVSSLEYPQPYPPDLRCNYSIRVERGLTVHLKFLDPFEIDDHQQVHCPYDQLQIYANGKNLGEFCGKQRPPDLDTSSNAVDLLFFTDESGDSRGWKLHYTTETIKCPQPKALDEFTIIQDPQPQYQFRDYFTVTCKQGYQLMEGNQALLSFTAVCQHDGTWHRAMPRCKIKNCGQPQSLSNGDFRYITTKGVTTYEASIQYHCHEPYYKMLTRAGSSESMRGIYTCTAQGIWKNEEEGEKMPRCLPVCGKPVNPVTQKERIIGGQPARPGNFPWQAFTTIYGPGGGALLGDRWILTAAHTIYPKYPNKGKNTNPRTLVFLGHTNMEQIQKLGHHPVRRVIIHPDYRQEEPDNFEGDIALLELENSVTLGPELLPICLPDNETFYGQGLMGYVSGFGTTGNRIPFHLRFVRLPVADREACQRWLWTKKDTSPFSQNMFCSGDPAVQQDACQGDSGGVFAVRDRNRDIWVATGIVSWGIGCGEGYGFYTKVLNYVDWIKKEMGDEN
uniprot
proteins
ec_number
3.4.21.41
uniprot
proteins
function
FUNCTION: Serine protease component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C1R catalyzes the first enzymatic step in the classical complement pathway: it is activated by the C1Q subcomplex of the C1 complex, which associates with IgG or IgM immunoglobulins complexed with antigens to form antigen-antibody complexes on the surface of pathogens. Immunoglobulin-binding promotes the autocatalytic cleavage and activation of C1R. Activated C1R then cleaves and activates C1S, the second protease of the classical complement pathway. It is unclear if C1R activates C1S within single, strained C1 complexes or between neighboring C1 complexes on surfaces. {ECO:0000250|UniProtKB:P00736}.
uniprot
proteins
mass_dalton
79936
uniprot
proteins
post_translational_modification
PTM: Cleaved and activated by autocatalytic processing to generate Complement C1r subcomponent heavy and light chains that are connected by disulfide bonds. {ECO:0000250|UniProtKB:P00736}.; PTM: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. {ECO:0000250|UniProtKB:P00736}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
12513694
uniprot
proteins
sequence_length
706
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P00736}. Cell surface {ECO:0000250|UniProtKB:P00736}. Note=Recruited to the surface of pathogens by the C1Q subcomplex. {ECO:0000250|UniProtKB:P00736}.
uniprot
proteins