Rnf126
entrez
70294
canonical
uniprot
Q91YL2
canonical
ensembl
ENSMUSG00000035890
resolver
ensp
ENSMUSP00000039486
resolver
ensp
ENSMUSP00000288488
resolver
ensp
ENSMUSP00000288489
resolver
enst
ENSMUST00000047203
resolver
genesymbol
Rnf126
resolver
uniprot
Q3U3G2
resolver
uniprot_entry
Q3U3G2_MOUSE
resolver
uniprot_entry
RN126_MOUSE
resolver
amino_acid_sequence
MAEASPQPGRYFCHCCSVEIVPRLPDYICPRCESGFIEELPEETRNTENGSAPSTAPTDQNRQPFENVDQHLFTLPQGYSQFAFGIFDDSFEIPTFPPGAQADDGRDPESRREREHQSRHRYGARQPRARLTARRATGRHEGVPTLEGIIQQLVNGIISPAAVPSLGLGPWGVLHSNPMDYAWGANGLDTIITQLLNQFENTGPPPADKEKIQALPTVPVTEEHVGSGLECPVCKEDYALGESVRQLPCNHLFHDSCIVPWLEQHDSCPVCRKSLTGQNTATNPPGLTGVGFSSSSSSSSSSSPSNENATSNS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination oF target proteins (By similarity). Depending on the associated E2 ligase, mediates 'Lys-27'-, 'Lys-29'-, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates (PubMed:23418353). Part of a BAG6-dependent quality control process ensuring that proteins of the secretory pathway that are mislocalized to the cytosol are degraded by the proteasome (By similarity). Probably acts by providing the ubiquitin ligase activity associated with the BAG6 complex and be responsible for ubiquitination of the hydrophobic mislocalized proteins and their targeting to the proteasome (By similarity). May also play a role in the endosomal recycling of IGF2R, the cation-independent mannose-6-phosphate receptor (By similarity). May play a role in the endosomal sorting and degradation of several membrane receptors including EGFR, FLT3, MET and CXCR4, by mediating their ubiquitination (PubMed:23418353). By ubiquitinating CDKN1A/p21 and targeting it for degradation, may also promote cell proliferation (By similarity). May monoubiquitinate AICDA (By similarity). Acts as a regulator of DNA repair by mediating 'Lys-27'- and 'Lys-29'-linked polyubiquitination of MRE11, thereby promoting the exonuclease activity of MRE11 (By similarity). {ECO:0000250|UniProtKB:Q9BV68, ECO:0000269|PubMed:23418353}.
uniprot
proteins
mass_dalton
34081
uniprot
proteins
mutagenesis
MUTAGEN 13; /note="C->A: Loss of interaction with EGFR and FLT3. No effect on E3 ubiquitin protein ligase activity but alters specificity for 'Lys-48'-linked chains; when associated with A-16."; /evidence="ECO:0000269|PubMed:23418353"; MUTAGEN 16; /note="C->A: Loss of interaction with EGFR and FLT3. No effect on E3 ubiquitin protein ligase activity but alters specificity for 'Lys-48'-linked chains; when associated with A-13."; /evidence="ECO:0000269|PubMed:23418353"; MUTAGEN 231; /note="C->A: Loss of E3 ubiquitin protein ligase activity."; /evidence="ECO:0000269|PubMed:23418353
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:23418353}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. May undergo autoubiquitination. {ECO:0000250|UniProtKB:Q9BV68, ECO:0000303|PubMed:23418353}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23277564
uniprot
proteins
pubmed
23418353
uniprot
proteins
pubmed
36563124
uniprot
proteins
sequence_length
313
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BV68}. Nucleus {ECO:0000250|UniProtKB:Q9BV68}.
uniprot
proteins