TRAP1
entrez
10131
canonical
uniprot
Q12931
canonical
ensembl
ENSG00000126602
resolver
ensp
ENSP00000246957
resolver
ensp
ENSP00000442070
resolver
ensp
ENSP00000458166
resolver
genesymbol
TRAP1
resolver
genesymbol_syn
HSP75
resolver
genesymbol_syn
HSPC5
resolver
hgnc
HGNC:16264
resolver
uniprot
A0A140VJY2
resolver
uniprot
B4DR68
resolver
uniprot
D3DUC8
resolver
uniprot
F5H897
resolver
uniprot
O43642
resolver
uniprot
O75235
resolver
uniprot
Q53FS6
resolver
uniprot
Q9UHL5
resolver
uniprot_entry
A0A140VJY2_HUMAN
resolver
uniprot_entry
Q53FS6_HUMAN
resolver
uniprot_entry
TRAP1_HUMAN
resolver
uniprot_sec
B4DR68
resolver
uniprot_sec
D3DUC8
resolver
uniprot_sec
F5H897
resolver
uniprot_sec
O43642
resolver
uniprot_sec
O75235
resolver
uniprot_sec
Q9UHL5
resolver
amino_acid_sequence
MARELRALLLWGRRLRPLLRAPALAAVPGGKPILCPRRTTAQLGPRRNPAWSLQAGRLFSTQTAEDKEEPLHSIISSTESVQGSTSKHEFQAETKKLLDIVARSLYSEKEVFIRELISNASDALEKLRHKLVSDGQALPEMEIHLQTNAEKGTITIQDTGIGMTQEELVSNLGTIARSGSKAFLDALQNQAEASSKIIGQFGVGFYSAFMVADRVEVYSRSAAPGSLGYQWLSDGSGVFEIAEASGVRTGTKIIIHLKSDCKEFSSEARVRDVVTKYSNFVSFPLYLNGRRMNTLQAIWMMDPKDVREWQHEEFYRYVAQAHDKPRYTLHYKTDAPLNIRSIFYVPDMKPSMFDVSRELGSSVALYSRKVLIQTKATDILPKWLRFIRGVVDSEDIPLNLSRELLQESALIRKLRDVLQQRLIKFFIDQSKKDAEKYAKFFEDYGLFMREGIVTATEQEVKEDIAKLLRYESSALPSGQLTSLSEYASRMRAGTRNIYYLCAPNRHLAEHSPYYEAMKKKDTEVLFCFEQFDELTLLHLREFDKKKLISVETDIVVDHYKEEKFEDRSPAAECLSEKETEELMAWMRNVLGSRVTNVKVTLRLDTHPAMVTVLEMGAARHFLRMQQLAKTQEERAQLLQPTLEINPRHALIKKLNQLRASEPGLAQLLVDQIYENAMIAAGLVDDPRAMVGRLNELLVKALERH
uniprot
proteins
function
FUNCTION: Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. {ECO:0000269|PubMed:23525905, ECO:0000269|PubMed:23564345, ECO:0000269|PubMed:23747254}.
uniprot
proteins
mass_dalton
80110
uniprot
proteins
protein_family
Heat shock protein 90 family
uniprot
proteins
pubmed
10545594
uniprot
proteins
pubmed
10652318
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
18663603
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23525905
uniprot
proteins
pubmed
23564345
uniprot
proteins
pubmed
23747254
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
7876093
uniprot
proteins
pubmed
8756626
uniprot
proteins
sequence_length
704
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:23564345}. Mitochondrion inner membrane {ECO:0000269|PubMed:23564345}. Mitochondrion matrix {ECO:0000269|PubMed:23564345}.
uniprot
proteins