CHST8
entrez
64377
canonical
uniprot
Q9H2A9
canonical
ensembl
ENSG00000124302
resolver
ensp
ENSP00000262622
resolver
ensp
ENSP00000392604
resolver
ensp
ENSP00000393879
resolver
ensp
ENSP00000499084
resolver
ensp
ENSP00000584997
resolver
ensp
ENSP00000584998
resolver
ensp
ENSP00000584999
resolver
ensp
ENSP00000585000
resolver
ensp
ENSP00000585001
resolver
ensp
ENSP00000585002
resolver
ensp
ENSP00000629555
resolver
enst
ENST00000262622
resolver
enst
ENST00000434302
resolver
enst
ENST00000438847
resolver
enst
ENST00000650847
resolver
enst
ENST00000914938
resolver
enst
ENST00000914939
resolver
enst
ENST00000914940
resolver
enst
ENST00000914941
resolver
enst
ENST00000914942
resolver
enst
ENST00000914943
resolver
enst
ENST00000959496
resolver
genesymbol
CHST8
resolver
hgnc
HGNC:15993
resolver
uniprot
Q9H3N2
resolver
uniprot_entry
CHST8_HUMAN
resolver
uniprot_sec
Q9H3N2
resolver
amino_acid_sequence
MTLRPGTMRLACMFSSILLFGAAGLLLFISLQDPTELAPQQVPGIKFNIRPRQPHHDLPPGGSQDGDLKEPTERVTRDLSSGAPRGRNLPAPDQPQPPLQRGTRLRLRQRRRRLLIKKMPAAATIPANSSDAPFIRPGPGTLDGRWVSLHRSQQERKRVMQEACAKYRASSSRRAVTPRHVSRIFVEDRHRVLYCEVPKAGCSNWKRVLMVLAGLASSTADIQHNTVHYGSALKRLDTFDRQGILHRLSTYTKMLFVREPFERLVSAFRDKFEHPNSYYHPVFGKAILARYRANASREALRTGSGVRFPEFVQYLLDVHRPVGMDIHWDHVSRLCSPCLIDYDFVGKFESMEDDANFFLSLIRAPRNLTFPRFKDRHSQEARTTARIAHQYFAQLSALQRQRTYDFYYMDYLMFNYSKPFADLY
uniprot
proteins
ec_number
2.8.2.-
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. Transfers sulfate to the 4-position of GalNAc in the context of GalNAcbeta1->4GlcNAcbeta1->R attached to both N-linked and core 2 branched O-linked oligosaccharides. Required for biosynthesis of glycoprotein hormones lutropin and thyrotropin, by mediating sulfation of their carbohydrate structures (PubMed:10988300, PubMed:11001942, PubMed:11445554, PubMed:28204496). Not active toward chondroitin and dermatan (PubMed:10988300, PubMed:11001942, PubMed:11445554). {ECO:0000269|PubMed:10988300, ECO:0000269|PubMed:11001942, ECO:0000269|PubMed:11445554, ECO:0000269|PubMed:28204496}.
uniprot
proteins
mass_dalton
48834
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; carbohydrate sulfation. {ECO:0000305|PubMed:11445554}.
uniprot
proteins
protein_family
Sulfotransferase 2 family
uniprot
proteins
pubmed
10988300
uniprot
proteins
pubmed
11001942
uniprot
proteins
pubmed
11445554
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15632154
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
22289416
uniprot
proteins
pubmed
28204496
uniprot
proteins
sequence_length
424
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 11..31; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins