Il10
entrez
16153
canonical
uniprot
P18893
canonical
ensembl
ENSMUSG00000016529
resolver
ensp
ENSMUSP00000016673
resolver
enst
ENSMUST00000016673
resolver
genesymbol
Il10
resolver
genesymbol_syn
Il-10
resolver
uniprot
Q0VBJ1
resolver
uniprot
Q3U879
resolver
uniprot_entry
IL10_MOUSE
resolver
uniprot_entry
Q3U879_MOUSE
resolver
uniprot_sec
Q0VBJ1
resolver
amino_acid_sequence
MPGSALLCCLLLLTGMRISRGQYSREDNNCTHFPVGQSHMLLELRTAFSQVKTFFQTKDQLDNILLTDSLMQDFKGYLGCQALSEMIQFYLVEVMPQAEKHGPEIKEHLNSLGEKLKTLRMRLRRCHRFLPCENKSKAVEQVKSDFNKLQDQGVYKAMNEFDIFINCIEAYMMIKMKS
uniprot
proteins
function
FUNCTION: Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF. Also interferes with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity) (PubMed:28473584). {ECO:0000250|UniProtKB:P22301, ECO:0000269|PubMed:28473584}.
uniprot
proteins
mass_dalton
20641
uniprot
proteins
protein_family
IL-10 family
uniprot
proteins
pubmed
1350294
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
2161559
uniprot
proteins
pubmed
28473584
uniprot
proteins
pubmed
8364028
uniprot
proteins
sequence_length
178
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P22301}.
uniprot
proteins