Kcne1
entrez
25471
canonical
uniprot
P15383
canonical
ensembl
ENSRNOG00000001984
resolver
ensembl
ENSRNOG00055017447
resolver
ensembl
ENSRNOG00060017747
resolver
ensembl
ENSRNOG00065013426
resolver
ensp
ENSRNOP00000002717
resolver
ensp
ENSRNOP00000086617
resolver
ensp
ENSRNOP00000087251
resolver
ensp
ENSRNOP00000092414
resolver
ensp
ENSRNOP00000099550
resolver
ensp
ENSRNOP00000100022
resolver
ensp
ENSRNOP00000103960
resolver
ensp
ENSRNOP00000106444
resolver
ensp
ENSRNOP00000108944
resolver
ensp
ENSRNOP00000111040
resolver
ensp
ENSRNOP00055023716
resolver
ensp
ENSRNOP00055023717
resolver
ensp
ENSRNOP00055023718
resolver
ensp
ENSRNOP00055023720
resolver
ensp
ENSRNOP00060024521
resolver
ensp
ENSRNOP00060024537
resolver
ensp
ENSRNOP00060024556
resolver
ensp
ENSRNOP00060024562
resolver
ensp
ENSRNOP00065017116
resolver
ensp
ENSRNOP00065017118
resolver
ensp
ENSRNOP00065017120
resolver
ensp
ENSRNOP00065017122
resolver
enst
ENSRNOT00000002717
resolver
enst
ENSRNOT00000096553
resolver
enst
ENSRNOT00000098014
resolver
enst
ENSRNOT00000114695
resolver
enst
ENSRNOT00000139012
resolver
enst
ENSRNOT00000146457
resolver
enst
ENSRNOT00000161047
resolver
enst
ENSRNOT00000166186
resolver
enst
ENSRNOT00000168964
resolver
enst
ENSRNOT00000173471
resolver
enst
ENSRNOT00055029526
resolver
enst
ENSRNOT00055029527
resolver
enst
ENSRNOT00055029528
resolver
enst
ENSRNOT00055029530
resolver
enst
ENSRNOT00060030360
resolver
enst
ENSRNOT00060030378
resolver
enst
ENSRNOT00060030400
resolver
enst
ENSRNOT00060030405
resolver
enst
ENSRNOT00065022081
resolver
enst
ENSRNOT00065022085
resolver
enst
ENSRNOT00065022087
resolver
enst
ENSRNOT00065022089
resolver
genesymbol
Kcne1
resolver
uniprot_entry
KCNE1_RAT
resolver
amino_acid_sequence
MALSNSTTVLPFLASLWQETDEPGGNMSADLARRSQLRDDSKLEALYILMVLGFFGFFTLGIMLSYIRSKKLEHSHDPFNVYIESDAWQEKGKALFQARVLESFRACYVIENQAAVEQPATHLPELKPLS
uniprot
proteins
function
FUNCTION: Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE1 beta subunit modulates the gating kinetics and enhances stability of the channel complex. Alters the gating of the delayed rectifier Kv channel containing KCNB1 alpha subunit (PubMed:19219384). Associates with KCNQ1/KVLQT1 alpha subunit to form the slowly activating delayed rectifier cardiac potassium (IKs) channel responsible for ventricular muscle action potential repolarization. The outward current reaches its steady state only after 50 seconds. Assembly with KCNH2/HERG alpha subunit Kv channel may regulate the rapidly activating component of the delayed rectifying potassium current (IKr) in heart (By similarity). {ECO:0000250|UniProtKB:P15382, ECO:0000269|PubMed:19219384}.
uniprot
proteins
mass_dalton
14699
uniprot
proteins
mutagenesis
MUTAGEN 77; /note="D->N: No current (homomultimers); one fourth of the WT current (heteromultimers)."; /evidence="ECO:0000269|PubMed:7605639"; MUTAGEN 103; /note="S->A: Abolishes inhibition by phosphorylation."; /evidence="ECO:0000269|PubMed:1553557
uniprot
proteins
post_translational_modification
PTM: Phosphorylation inhibits the potassium current.; PTM: N-glycosylation at Asn-26 occurs post-translationally, and requires prior cotranslational glycosylation at Asn-5. {ECO:0000250}.
uniprot
proteins
protein_family
Potassium channel KCNE family
uniprot
proteins
pubmed
14679187
uniprot
proteins
pubmed
1553557
uniprot
proteins
pubmed
19219384
uniprot
proteins
pubmed
2183220
uniprot
proteins
pubmed
2229022
uniprot
proteins
pubmed
2344412
uniprot
proteins
pubmed
3194754
uniprot
proteins
pubmed
7605639
uniprot
proteins
sequence_length
130
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14679187, ECO:0000269|PubMed:19219384}; Single-pass type I membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:19219384}. Membrane raft {ECO:0000250|UniProtKB:P15382}. Note=Colocalizes with KCNB1 at the plasma membrane. Restrictively localized in the apical membrane portion of epithelial cells. Targets to the membrane raft when associated with KCNQ1 (By similarity). {ECO:0000250|UniProtKB:P15382, ECO:0000269|PubMed:19219384}.
uniprot
proteins
transmembrane_region
TRANSMEM 45..67; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins