Dctd
entrez
320685
canonical
uniprot
Q8K2D6
canonical
ensembl
ENSMUSG00000031562
resolver
ensp
ENSMUSP00000033966
resolver
ensp
ENSMUSP00000126733
resolver
ensp
ENSMUSP00000133445
resolver
ensp
ENSMUSP00000306787
resolver
ensp
ENSMUSP00000306790
resolver
ensp
ENSMUSP00000306791
resolver
enst
ENSMUST00000033966
resolver
enst
ENSMUST00000170263
resolver
enst
ENSMUST00000174278
resolver
genesymbol
Dctd
resolver
uniprot
G3X908
resolver
uniprot
Q8BP55
resolver
uniprot_entry
DCTD_MOUSE
resolver
uniprot_entry
G3X908_MOUSE
resolver
uniprot_sec
Q8BP55
resolver
activity_regulation
ACTIVITY REGULATION: Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP. {ECO:0000250|UniProtKB:P32321}.
uniprot
proteins
amino_acid_sequence
MSDISCKKRDDYLEWPEYFMAVAFLSAQRSKDPSSQVGACIVNTENKIVGIGYNGMPNGCSDDLLPWRRTAENKLDTKYPYVCHAELNAIMNKNSADVKGCSMYVALFPCNECAKLIIQAGIKEVIFMSDKYHDSEETTAARLLFKLAGVTFRKFTPKYSKIVIDFDSINSRPSQKPQ
uniprot
proteins
ec_number
3.5.4.12
uniprot
proteins
function
FUNCTION: Catalyzes the deamination of dCMP to dUMP, providing the nucleoside monophosphate substrate for the thymidylate synthase/TYMS. Also, part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate). Catalyzes the first step in that pathway, the deamination of 5-hydroxymethyl-dCMP (hmdCMP). {ECO:0000250|UniProtKB:P32321}.
uniprot
proteins
mass_dalton
20059
uniprot
proteins
protein_family
Cytidine and deoxycytidylate deaminase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
178
uniprot
proteins