Dnase2
entrez
171575
canonical
uniprot
Q9QZK8
canonical
ensembl
ENSRNOG00000023830
resolver
ensembl
ENSRNOG00055007827
resolver
ensembl
ENSRNOG00060012300
resolver
ensembl
ENSRNOG00065010869
resolver
ensp
ENSRNOP00000014887
resolver
ensp
ENSRNOP00055010511
resolver
ensp
ENSRNOP00060016451
resolver
ensp
ENSRNOP00065013547
resolver
enst
ENSRNOT00000014887
resolver
enst
ENSRNOT00055013133
resolver
enst
ENSRNOT00060020870
resolver
enst
ENSRNOT00065017646
resolver
genesymbol
Dnase2
resolver
genesymbol_syn
Dnase2a
resolver
genesymbol_syn
Dnl2
resolver
uniprot
Q5BKC7
resolver
uniprot_entry
DNS2A_RAT
resolver
uniprot_sec
Q5BKC7
resolver
amino_acid_sequence
MAAPSSLLLAALLWVPAEALSCYGDSGRPVDWFVVYKLPANSGSGDKPWKGLMYKYMDQNSEGWQDGVGHIDSKDGAVGLTLQPLYQKNSSQLAFLLYNDQPPKSSSAQDSSSRGHTKGVLLLDQEGGFWLVHSVPRFPSPASSGAYSWPPNARTYGQTLLCVSLPFSQFPGIGKQLTYTYPLVYDHKLEGIFAQKLPDLEEVTKGHHVLREPWNSSVILTSRAGTTFQSFAKFGKFGDDLYSGWLAAALGTNLQVQFWPNSPGILPSNCSGTHKILDVTETGFPGPSGPTFNATEDHSKWCVAPEGPWVCVGDMNRNKRETHRGGGTLCTQVPALWKAFRSLVKACKPC
uniprot
proteins
ec_number
3.1.22.1
uniprot
proteins
function
FUNCTION: Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the clearance of nucleic acids generated through apoptosis, hence preventing autoinflammation. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver and bone marrow, where it degrades nuclear DNA expelled from erythroid precursor cells. {ECO:0000250|UniProtKB:O00115, ECO:0000250|UniProtKB:P56542}.
uniprot
proteins
mass_dalton
38175
uniprot
proteins
protein_family
DNase II family
uniprot
proteins
pubmed
10558878
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
350
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:P56542}.
uniprot
proteins