RAMP1
entrez
10267
canonical
uniprot
O60894
canonical
ensembl
ENSG00000132329
resolver
ensp
ENSP00000254661
resolver
ensp
ENSP00000384688
resolver
ensp
ENSP00000386046
resolver
ensp
ENSP00000386720
resolver
enst
ENST00000254661
resolver
enst
ENST00000403885
resolver
enst
ENST00000404910
resolver
enst
ENST00000409726
resolver
genesymbol
RAMP1
resolver
hgnc
HGNC:9843
resolver
uniprot
E9PC20
resolver
uniprot
Q6FGS5
resolver
uniprot_entry
E9PC20_HUMAN
resolver
uniprot_entry
RAMP1_HUMAN
resolver
uniprot_sec
Q6FGS5
resolver
amino_acid_sequence
MARALCRLPRRGLWLLLAHHLFMTTACQEANYGALLRELCLTQFQVDMEAVGETLWCDWGRTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGRYFRSCPISGRAVRDPPGSILYPFIVVPITVTLLVTALVVWQSKRTEGIV
uniprot
proteins
function
FUNCTION: Accessory protein that interacts with and modulates the function of G protein-coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL) and calcitonin receptor (CALCR) (PubMed:33602864, PubMed:9620797, PubMed:35324283, PubMed:38603770). Required for the transport of CALCRL to the plasma membrane (PubMed:9620797). Together with CALCRL, form the receptor complex for the calcitonin gene-related peptides CGRP1/CALCA and CGRP2/CALCB (PubMed:33602864, PubMed:9620797). Together with CALCR, form the AMYR1 receptor complex for amylin/IAPP and CGRP1/CALCA (PubMed:35324283, PubMed:38603770). {ECO:0000269|PubMed:33602864, ECO:0000269|PubMed:35324283, ECO:0000269|PubMed:38603770, ECO:0000269|PubMed:9620797}.
uniprot
proteins
mass_dalton
16988
uniprot
proteins
protein_family
RAMP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18725456
uniprot
proteins
pubmed
20826335
uniprot
proteins
pubmed
33602864
uniprot
proteins
pubmed
35324283
uniprot
proteins
pubmed
38603770
uniprot
proteins
pubmed
9620797
uniprot
proteins
sequence_length
148
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:33602864}; Single-pass type I membrane protein {ECO:0000269|PubMed:33602864}.
uniprot
proteins
transmembrane_region
TRANSMEM 119..140; /note="Helical"; /evidence="ECO:0000269|PubMed:33602864, ECO:0007744|PDB:7KNU
uniprot
proteins