CD44
entrez
960
canonical
uniprot
P16070
canonical
ensembl
ENSG00000026508
resolver
ensp
ENSP00000263398
resolver
ensp
ENSP00000278386
resolver
ensp
ENSP00000309732
resolver
ensp
ENSP00000389830
resolver
ensp
ENSP00000392331
resolver
ensp
ENSP00000398099
resolver
ensp
ENSP00000398632
resolver
ensp
ENSP00000404447
resolver
ensp
ENSP00000574071
resolver
ensp
ENSP00000574072
resolver
ensp
ENSP00000574073
resolver
ensp
ENSP00000574076
resolver
ensp
ENSP00000574077
resolver
ensp
ENSP00000574081
resolver
ensp
ENSP00000574082
resolver
ensp
ENSP00000605570
resolver
ensp
ENSP00000639392
resolver
ensp
ENSP00000639397
resolver
ensp
ENSP00000639403
resolver
ensp
ENSP00000639404
resolver
ensp
ENSP00000639405
resolver
ensp
ENSP00000639407
resolver
ensp
ENSP00000639412
resolver
ensp
ENSP00000639414
resolver
ensp
ENSP00000639419
resolver
ensp
ENSP00000639422
resolver
ensp
ENSP00000639426
resolver
ensp
ENSP00000639435
resolver
ensp
ENSP00000783014
resolver
ensp
ENSP00000783016
resolver
ensp
ENSP00000795275
resolver
genesymbol
CD44
resolver
genesymbol_syn
LHR
resolver
genesymbol_syn
MDU2
resolver
genesymbol_syn
MDU3
resolver
genesymbol_syn
MIC4
resolver
hgnc
HGNC:1681
resolver
uniprot
A5YRN9
resolver
uniprot
B6EAT9
resolver
uniprot
D3DR12
resolver
uniprot
D3DR13
resolver
uniprot
O95370
resolver
uniprot
P22511
resolver
uniprot
Q04858
resolver
uniprot
Q13419
resolver
uniprot
Q13957
resolver
uniprot
Q13958
resolver
uniprot
Q13959
resolver
uniprot
Q13960
resolver
uniprot
Q13961
resolver
uniprot
Q13967
resolver
uniprot
Q13968
resolver
uniprot
Q13980
resolver
uniprot
Q15861
resolver
uniprot
Q16064
resolver
uniprot
Q16065
resolver
uniprot
Q16066
resolver
uniprot
Q16208
resolver
uniprot
Q16522
resolver
uniprot
Q86T72
resolver
uniprot
Q86Z27
resolver
uniprot
Q8N694
resolver
uniprot
Q92493
resolver
uniprot
Q96J24
resolver
uniprot
Q9H5A5
resolver
uniprot
Q9UC28
resolver
uniprot
Q9UC29
resolver
uniprot
Q9UC30
resolver
uniprot
Q9UCB0
resolver
uniprot
Q9UJ36
resolver
uniprot_entry
CD44_HUMAN
resolver
uniprot_sec
A5YRN9
resolver
uniprot_sec
B6EAT9
resolver
uniprot_sec
D3DR12
resolver
uniprot_sec
D3DR13
resolver
uniprot_sec
O95370
resolver
uniprot_sec
P22511
resolver
uniprot_sec
Q04858
resolver
uniprot_sec
Q13419
resolver
uniprot_sec
Q13957
resolver
uniprot_sec
Q13958
resolver
uniprot_sec
Q13959
resolver
uniprot_sec
Q13960
resolver
uniprot_sec
Q13961
resolver
uniprot_sec
Q13967
resolver
uniprot_sec
Q13968
resolver
uniprot_sec
Q13980
resolver
uniprot_sec
Q15861
resolver
uniprot_sec
Q16064
resolver
uniprot_sec
Q16065
resolver
uniprot_sec
Q16066
resolver
uniprot_sec
Q16208
resolver
uniprot_sec
Q16522
resolver
uniprot_sec
Q86T72
resolver
uniprot_sec
Q86Z27
resolver
uniprot_sec
Q8N694
resolver
uniprot_sec
Q92493
resolver
uniprot_sec
Q96J24
resolver
uniprot_sec
Q9H5A5
resolver
uniprot_sec
Q9UC28
resolver
uniprot_sec
Q9UC29
resolver
uniprot_sec
Q9UC30
resolver
uniprot_sec
Q9UCB0
resolver
uniprot_sec
Q9UJ36
resolver
amino_acid_sequence
MDKFWWHAAWGLCLVPLSLAQIDLNITCRFAGVFHVEKNGRYSISRTEAADLCKAFNSTLPTMAQMEKALSIGFETCRYGFIEGHVVIPRIHPNSICAANNTGVYILTSNTSQYDTYCFNASAPPEEDCTSVTDLPNAFDGPITITIVNRDGTRYVQKGEYRTNPEDIYPSNPTDDDVSSGSSSERSSTSGGYIFYTFSTVHPIPDEDSPWITDSTDRIPATTLMSTSATATETATKRQETWDWFSWLFLPSESKNHLHTTTQMAGTSSNTISAGWEPNEENEDERDRHLSFSGSGIDDDEDFISSTISTTPRAFDHTKQNQDWTQWNPSHSNPEVLLQTTTRMTDVDRNGTTAYEGNWNPEAHPPLIHHEHHEEEETPHSTSTIQATPSSTTEETATQKEQWFGNRWHEGYRQTPKEDSHSTTGTAAASAHTSHPMQGRTTPSPEDSSWTDFFNPISHPMGRGHQAGRRMDMDSSHSITLQPTANPNTGLVEDLDRTGPLSMTTQQSNSQSFSTSHEGLEEDKDHPTTSTLTSSNRNDVTGGRRDPNHSEGSTTLLEGYTSHYPHTKESRTFIPVTSAKTGSFGVTAVTVGDSNSNVNRSLSGDQDTFHPSGGSHTTHGSESDGHSHGSQEGGANTTSGPIRTPQIPEWLIILASLLALALILAVCIAVNSRRRCGQKKKLVINSGNGAVEDRKPSGLNGEASKSQEMVHLVNKESSETPDQFMTADETRNLQNVDMKIGV
uniprot
proteins
function
FUNCTION: Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640). Upon interaction with LGALS9 ligand, activates downstream signaling components including LCK, ERK and MAPK to promotes NK cell activation (PubMed:37006235). {ECO:0000269|PubMed:15123640, ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:18757307, ECO:0000269|PubMed:19703720, ECO:0000269|PubMed:22726066, ECO:0000269|PubMed:23589287, ECO:0000269|PubMed:37006235, ECO:0000269|PubMed:7528188}.; FUNCTION: (Microbial infection) Promotes foot-and-mouth disease virus internalization via macropinocytosis. {ECO:0000269|PubMed:40544280}.
uniprot
proteins
mass_dalton
81538
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors. {ECO:0000269|PubMed:12883358}.; PTM: N-glycosylated. {ECO:0000269|PubMed:12883358, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:22171320}.; PTM: O-glycosylated; contains chondroitin sulfate glycans which can be more or less sulfated and whose number may affect the accessibility of specific proteinases to their cleavage site(s). It is uncertain if O-glycosylation occurs on Thr-637 or Thr-638. {ECO:0000269|PubMed:12883358, ECO:0000269|PubMed:22171320, ECO:0000269|PubMed:25326458}.; PTM: Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672. {ECO:0000269|PubMed:12032545, ECO:0000269|PubMed:9580567}.
uniprot
proteins
pubmed
10933060
uniprot
proteins
pubmed
12032545
uniprot
proteins
pubmed
12511867
uniprot
proteins
pubmed
1281868
uniprot
proteins
pubmed
12883358
uniprot
proteins
pubmed
1465456
uniprot
proteins
pubmed
14992719
uniprot
proteins
pubmed
15123640
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
16541107
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17085435
uniprot
proteins
pubmed
1717145
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
1840487
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
18757307
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
1922057
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19381274
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19703720
uniprot
proteins
pubmed
1991450
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
2007624
uniprot
proteins
pubmed
2056274
uniprot
proteins
pubmed
20962267
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22171320
uniprot
proteins
pubmed
22726066
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23589287
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2466575
uniprot
proteins
pubmed
2466576
uniprot
proteins
pubmed
25195884
uniprot
proteins
pubmed
25326458
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29777959
uniprot
proteins
pubmed
32337544
uniprot
proteins
pubmed
36213313
uniprot
proteins
pubmed
37006235
uniprot
proteins
pubmed
37453717
uniprot
proteins
pubmed
40544280
uniprot
proteins
pubmed
7508842
uniprot
proteins
pubmed
7508992
uniprot
proteins
pubmed
7527301
uniprot
proteins
pubmed
7528188
uniprot
proteins
pubmed
8148709
uniprot
proteins
pubmed
8352881
uniprot
proteins
pubmed
8636151
uniprot
proteins
pubmed
9580567
uniprot
proteins
sequence_length
742
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22726066, ECO:0000269|PubMed:23589287, ECO:0000269|PubMed:40544280}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, microvillus {ECO:0000250|UniProtKB:P15379}. Secreted {ECO:0000269|PubMed:25326458, ECO:0000269|PubMed:36213313, ECO:0000269|PubMed:37453717}. Note=Colocalizes with actin in membrane protrusions at wounding edges. Co-localizes with RDX, EZR and MSN in microvilli. Localizes to cholesterol-rich membrane-bound lipid raft domains. {ECO:0000250|UniProtKB:P15379, ECO:0000269|PubMed:23589287}.
uniprot
proteins
transmembrane_region
TRANSMEM 650..670; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins