Cyp26b1
entrez
232174
canonical
uniprot
Q811W2
canonical
ensembl
ENSMUSG00000063415
resolver
ensp
ENSMUSP00000076886
resolver
ensp
ENSMUSP00000128391
resolver
ensp
ENSMUSP00000144836
resolver
ensp
ENSMUSP00000145092
resolver
enst
ENSMUST00000077705
resolver
enst
ENSMUST00000168003
resolver
enst
ENSMUST00000204146
resolver
enst
ENSMUST00000205228
resolver
genesymbol
Cyp26b1
resolver
uniprot
A0A0N4SUV4
resolver
uniprot
Q3TM12
resolver
uniprot_entry
A0A0N4SUV4_MOUSE
resolver
uniprot_entry
CP26B_MOUSE
resolver
uniprot_sec
Q3TM12
resolver
amino_acid_sequence
MLFEGLELVSALATLAACLVSVTLLLAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILLGEHQLVSTEWPRSARVLLGPNTVANSIGDIHRNKRKVFSKIFSHEALESYLPKIQLVIQDTLRAWSSQPEAINVYQEAQRLTFRMAVRVLLGFSIPEEDLGHLFEVYQQFVENVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYSDALDILIESSKEHGKEMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPAVLEKLREELRAQGLLHGGGCPCEGTLRLDTLSSLRYLDCVIKEVMRLFTPVSGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDVNVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRFELATRTFPRITLVPVLHPVDGLSVKFFGLDSNQNEILPETEAMLSATV
uniprot
proteins
ec_number
1.14.13.-
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of retinoates (RAs), the active metabolites of vitamin A, and critical signaling molecules in animals (Probable). RAs exist as at least four different isomers: all-trans-RA (atRA), 9-cis-RA, 13-cis-RA, and 9,13-dicis-RA, where atRA is considered to be the biologically active isomer, although 9-cis-RA and 13-cis-RA also have activity (By similarity). Catalyzes the hydroxylation of atRA primarily at C-4 and C-18, thereby contributing to the regulation of atRA homeostasis and signaling (Probable). Hydroxylation of atRA limits its biological activity and initiates a degradative process leading to its eventual elimination (By similarity). Involved in the conversion of atRA to all-trans-4-oxo-RA (Probable). Can oxidize all-trans-13,14-dihydroretinoate (DRA) to metabolites which could include all-trans-4-oxo-DRA, all-trans-4-hydroxy-DRA, all-trans-5,8-epoxy-DRA, and all-trans-18-hydroxy-DRA (Probable). Shows preference for the following substrates: atRA > 9-cis-RA > 13-cis-RA (By similarity). Plays a central role in germ cell development: acts by degrading RAs in the developing testis, preventing STRA8 expression, thereby leading to delay of meiosis (PubMed:16461896, PubMed:16574820, PubMed:19838304). Required for the maintenance of the undifferentiated state of male germ cells during embryonic development in Sertoli cells, inducing arrest in G0 phase of the cell cycle and preventing meiotic entry (PubMed:16461896, PubMed:16574820, PubMed:19838304). Plays a role in skeletal development, both at the level of patterning and in the ossification of bone and the establishment of some synovial joints (PubMed:22019272). Essential for postnatal survival (PubMed:16461896, PubMed:16574820, PubMed:19838304). {ECO:0000250|UniProtKB:Q9NR63, ECO:0000269|PubMed:16461896, ECO:0000269|PubMed:16574820, ECO:0000269|PubMed:19838304, ECO:0000269|PubMed:22019272, ECO:0000305|PubMed:15911617}.; FUNCTION: Also has a significant activity in oxidation of tazarotenic acid and may therefore metabolize that xenobiotic in vivo. {ECO:0000250|UniProtKB:Q9NR63}.
uniprot
proteins
mass_dalton
57375
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
12617826
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15911617
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16461896
uniprot
proteins
pubmed
16574820
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19838304
uniprot
proteins
pubmed
22019272
uniprot
proteins
sequence_length
512
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O43174}; Peripheral membrane protein {ECO:0000250|UniProtKB:O43174}. Microsome membrane {ECO:0000250|UniProtKB:O43174}; Peripheral membrane protein {ECO:0000250|UniProtKB:O43174}.
uniprot
proteins