Senp2
entrez
75826
canonical
uniprot
Q91ZX6
canonical
ensembl
ENSMUSG00000022855
resolver
ensp
ENSMUSP00000023561
resolver
ensp
ENSMUSP00000287492
resolver
genesymbol
Senp2
resolver
genesymbol_syn
Smt3ip2
resolver
genesymbol_syn
Supr1
resolver
uniprot
Q544T8
resolver
uniprot
Q811R3
resolver
uniprot
Q9D4Z0
resolver
uniprot_entry
SENP2_MOUSE
resolver
uniprot_sec
Q544T8
resolver
uniprot_sec
Q811R3
resolver
uniprot_sec
Q9D4Z0
resolver
amino_acid_sequence
MYRWLAKVLGTILRLCERPAPGARALLKRRRSSSTLFSTAVDTDEIPAKRPRLDCFIHQVKNSLYNAASLFGFPFQLTTKPMVSSACNGTRNVAPSGEVFSNSSSCELMSSGSCSSMLKLGNKSPNGISDYPKIRVTVTRDQPRRVLPSFGFTLKSEGYNRRPSGRRHSKSNPESSLTWKPQEQGVTEMISEEGGKGVRRPHCTVEEGVQKDEREKYRKLLERLKEGAHGSTFPPTVSHHSSQRIQMDTLKTKGWVEEQNHGVRTTHFVPKQYRVVETRGPLCSMRSEKRYSKGKADTEKVVGLRFEKEGTRGHQMEPDLSEEVSARLRLGSGSNGLLRRKISVLEIKEKNFPSKEKDRRTEDLFEFTEDMEKEISNALGHGPPDEILSSAFKLRITRGDIQTLKNYHWLNDEVINFYMNLLVERSKKQGYPALHAFSTFFYPKLKSGGYQAVKRWTKGVNLFEQELVLVPIHRKVHWSLVVMDLRKKCLKYLDSMGQKGHRICEILLQYLQDESKTKRNTDLNLLEWTHYSMKPHEIPQQLNGSDCGMFTCKYADYISRDKPITFTQHQMPLFRKKMVWEILHQQLL
uniprot
proteins
ec_number
3.4.22.-
uniprot
proteins
function
FUNCTION: Protease that catalyzes two essential functions in the SUMO pathway (PubMed:11489887, PubMed:20194620). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (By similarity). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (PubMed:11489887, PubMed:20194620, PubMed:27637147). May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (PubMed:11489887). Deconjugates SUMO2 from MTA1 (By similarity). Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB (PubMed:20194620). Acts as a regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS and STING1 during the late phase of viral infection (PubMed:27637147). {ECO:0000250|UniProtKB:Q9HC62, ECO:0000269|PubMed:11489887, ECO:0000269|PubMed:20194620, ECO:0000269|PubMed:27637147}.; FUNCTION: [Isoform 3]: Activates transcription. {ECO:0000269|PubMed:12419228}.
uniprot
proteins
mass_dalton
67579
uniprot
proteins
mutagenesis
MUTAGEN 547; /note="C->A: Abolishes protease activity."; /evidence="ECO:0000269|PubMed:11489887, ECO:0000269|PubMed:12419228
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated; which leads to proteasomal degradation. {ECO:0000250|UniProtKB:Q9HC62}.
uniprot
proteins
protein_family
Peptidase C48 family
uniprot
proteins
pubmed
11489887
uniprot
proteins
pubmed
12419228
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20194620
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27637147
uniprot
proteins
sequence_length
588
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:Q9HC62}. Nucleus membrane {ECO:0000250|UniProtKB:Q9HC62}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9HC62}; Nucleoplasmic side {ECO:0000250|UniProtKB:Q9HC62}. Note=Shuttles between cytoplasm and nucleus. {ECO:0000250|UniProtKB:Q9HC62}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:11489887}. Cytoplasmic vesicle {ECO:0000269|PubMed:11489887}. Note=Found in the cytoplasm and in cytoplasmic vesicles, together with axin. {ECO:0000269|PubMed:11489887}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus, PML body {ECO:0000269|PubMed:12419228}.
uniprot
proteins