Cdyl
entrez
12593
canonical
uniprot
Q9WTK2
canonical
ensembl
ENSMUSG00000059288
resolver
ensp
ENSMUSP00000074707
resolver
ensp
ENSMUSP00000131784
resolver
ensp
ENSMUSP00000160791
resolver
genesymbol
Cdyl
resolver
uniprot
Q3U0W2
resolver
uniprot
Q6P6N3
resolver
uniprot_entry
CDYL_MOUSE
resolver
uniprot_sec
Q3U0W2
resolver
uniprot_sec
Q6P6N3
resolver
amino_acid_sequence
MGIGNSQPNSQEAQLCTLPEKAEQPTDDNTCQQNNVVPATVSEPDQASPAIQDAETQVESIVDKRKNKKGKTEYLVRWKGYDSEDDTWEPEQHLVNCEEYIHDFNRRHNERQKEGSLARASRASPSNARKQISRSTHSTLSKTNSKALVVGKDHESKSSQLLAASQKFRKNPAPSLANRKNMDLAKSGIKILVPKSPVKGRTSVDGFQGESPEKLDPVDQGAEDTVAPEVTAEKPTGALLGPGAERARMGSRPRIHPLVPQVSGPVTAAMATGLAVNGKGTSPFMDALAANGTVTIQTSVTGVTAGKRKFIDDRRDQPFDKRLRFSVRQTESAYRYRDIVVRKQDGFTHILLSTKSSENNSLNPEVMKEVQSALSTAAADDSKLVLLSAVGSVFCCGLDFIYFIRRLTDDRKRESTKMADAIRNFVNTFIQFKKPIIVAVNGPAIGLGASILPLCDVVWANEKAWFQTPYTTFGQSPDGCSTVMFPKIMGGASANEMLFSGRKLTAQEACGKGLVSQVFWPGTFTQEVMVRIKELASCNPVVLEESKALVRCNMKMELEQANERECEVLKKIWGSAQGMDSMLKYLQRKIDEF
uniprot
proteins
ec_number
2.3.1.48
uniprot
proteins
ec_number
4.2.1.-
uniprot
proteins
function
FUNCTION: [Isoform 2]: Chromatin reader protein that recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) (PubMed:12947414). Part of multimeric repressive chromatin complexes, where it is required for transmission and restoration of repressive histone marks, thereby preserving the epigenetic landscape (PubMed:12947414). Required for chromatin targeting and maximal enzymatic activity of Polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes (By similarity). Acts as a corepressor for REST by facilitating histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression (By similarity). Involved in X chromosome inactivation in females: recruited to Xist RNA-coated X chromosome and facilitates propagation of H3K9me2 by anchoring EHMT2 (PubMed:24144980). Promotes EZH2 accumulation and H3K27me3 methylation at DNA double strand breaks (DSBs), thereby facilitating transcriptional repression at sites of DNA damage and homology-directed repair of DSBs (By similarity). Required for neuronal migration during brain development by repressing expression of RHOA (PubMed:28076783). By repressing the expression of SCN8A, contributes to the inhibition of intrinsic neuronal excitability and epileptogenesis (PubMed:28842554). In addition to acting as a chromatin reader, acts as a hydro-lyase (By similarity). Shows crotonyl-coA hydratase activity by mediating the conversion of crotonyl-CoA ((2E)-butenoyl-CoA) to beta-hydroxybutyryl-CoA (3-hydroxybutanoyl-CoA), thereby acting as a negative regulator of histone crotonylation (By similarity). Histone crotonylation is required during spermatogenesis; down-regulation of histone crotonylation by CDYL regulates the reactivation of sex chromosome-linked genes in round spermatids and histone replacement in elongating spermatids (PubMed:28803779). By regulating histone crotonylation and trimethylation of H3K27, may be involved in stress-induced depression-like behaviors, possibly by regulating VGF expression (PubMed:30665597). May have histone acetyltransferase activity; such activity is however unsure in vivo (PubMed:12072557). {ECO:0000250|UniProtKB:Q9Y232, ECO:0000269|PubMed:12072557, ECO:0000269|PubMed:12947414, ECO:0000269|PubMed:24144980, ECO:0000269|PubMed:28076783, ECO:0000269|PubMed:28803779, ECO:0000269|PubMed:28842554, ECO:0000269|PubMed:30665597}.; FUNCTION: [Isoform 1]: Not able to recognize and bind histone H3K9me3, histone H3K27me2 and histone H3K27me3, due to the presence of a N-terminal extension that inactivates the chromo domain. {ECO:0000250|UniProtKB:Q9Y232}.
uniprot
proteins
mass_dalton
65211
uniprot
proteins
mutagenesis
MUTAGEN 516; /note="S->A: Abolishes CoA-binding. No effect on transcriptional repressor activity."; /evidence="ECO:0000269|PubMed:12947414"; MUTAGEN 588..589; /note="RK->AA: Abolishes CoA-binding. No effect on transcriptional repressor activity."; /evidence="ECO:0000269|PubMed:12947414
uniprot
proteins
pubmed
10192397
uniprot
proteins
pubmed
12072557
uniprot
proteins
pubmed
12947414
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24144980
uniprot
proteins
pubmed
27932493
uniprot
proteins
pubmed
28076783
uniprot
proteins
pubmed
28803779
uniprot
proteins
pubmed
28842554
uniprot
proteins
pubmed
29177481
uniprot
proteins
pubmed
30665597
uniprot
proteins
sequence_length
593
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:12072557, ECO:0000269|PubMed:12947414, ECO:0000269|PubMed:24144980, ECO:0000269|PubMed:29177481}. Chromosome {ECO:0000269|PubMed:12947414, ECO:0000269|PubMed:24144980, ECO:0000269|PubMed:29177481}. Note=Recognizes and binds histone H3 trimethylated at 'Lys-9', dimethylated at 'Lys-27' and trimethylated at 'Lys-27' (H3K9me3, H3K27me2 and H3K27me3, respectively) on chromatin (PubMed:24144980). Multimerization is required for chromatin-binding (By similarity). Recruited to Xist RNA-coated X chromosome (PubMed:24144980). Recruited to sites of DNA double strand breaks in a PARP1-dependent fashion (PubMed:29177481). {ECO:0000250|UniProtKB:Q9Y232, ECO:0000269|PubMed:24144980, ECO:0000269|PubMed:29177481}.
uniprot
proteins