Lynx1
entrez
23936
canonical
uniprot
P0DP60
canonical
ensembl
ENSMUSG00000022594
resolver
ensp
ENSMUSP00000023259
resolver
enst
ENSMUST00000023259
resolver
genesymbol
Lynx1
resolver
uniprot
Q08EF7
resolver
uniprot
Q3TRB5
resolver
uniprot
Q9WVC2
resolver
uniprot_entry
LYNX1_MOUSE
resolver
uniprot_sec
Q08EF7
resolver
uniprot_sec
Q3TRB5
resolver
uniprot_sec
Q9WVC2
resolver
amino_acid_sequence
MTHLLTVFLVALMGLPVAQALECHVCAYNGDNCFKPMRCPAMATYCMTTRTYFTPYRMKVRKSCVPSCFETVYDGYSKHASATSCCQYYLCNGAGFATPVTLALVPALLATFWSLL
uniprot
proteins
function
FUNCTION: Acts in different tissues through interaction to nicotinic acetylcholine receptors (nAChRs) (PubMed:10402197). The proposed role as modulator of nAChR activity seems to be dependent on the nAChR subtype and stoichiometry, and to involve an effect on nAChR trafficking and its cell surface expression, and on single channel properties of the nAChR inserted in the plasma membrane. Modulates functional properties of nicotinic acetylcholine receptors (nAChRs) to prevent excessive excitation, and hence neurodegeneration. Enhances desensitization by increasing both the rate and extent of desensitization of alpha-4:beta-2-containing nAChRs and slowing recovery from desensitization. Promotes large amplitude ACh-evoked currents through alpha-4:beta-2 nAChRs (PubMed:10402197, PubMed:11906696). Is involved in regulation of the nAChR pentameric assembly in the endoplasmic reticulum. Shifts stoichiometry from high sensitivity alpha-4(2):beta-2(3) to low sensitivity alpha-4(3):beta-2(2) nAChR (PubMed:25193667). In vitro modulates alpha-3:beta-4-containing nAChRs. Reduces cell surface expression of (alpha-3:beta-4)(2):beta-4 and (alpha-3:beta-4)(2):alpha-5 nAChRs suggesting an interaction with nAChR alpha-3(-):(+)beta-4 subunit interfaces and an allosteric mode. Corresponding single channel effects characterized by decreased unitary conductance, altered burst proportions and enhanced desensitization/inactivation seem to depend on nAChR alpha:alpha subunit interfaces and are greater in (alpha-3:beta-2)(2):alpha-3 when compared to (alpha-3:beta-2)(2):alpha-5 nAChRs (By similarity). Prevents plasticity in the primary visual cortex late in life (PubMed:21071629). {ECO:0000250|UniProtKB:P0DP58, ECO:0000269|PubMed:10402197, ECO:0000269|PubMed:11906696, ECO:0000269|PubMed:21071629, ECO:0000269|PubMed:25193667}.
uniprot
proteins
mass_dalton
12835
uniprot
proteins
pubmed
10402197
uniprot
proteins
pubmed
11906696
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16950157
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21071629
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25193667
uniprot
proteins
sequence_length
116
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Lipid-anchor, GPI-anchor {ECO:0000255}. Cell projection, dendrite {ECO:0000269|PubMed:10402197}. Endoplasmic reticulum {ECO:0000269|PubMed:25193667}. Note=Detected in Purkinje cells soma and proximal dendrites. {ECO:0000269|PubMed:10402197}.
uniprot
proteins