Psap
entrez
25524
canonical
uniprot
P10960
canonical
ensembl
ENSRNOG00000000571
resolver
ensp
ENSRNOP00000000696
resolver
ensp
ENSRNOP00000096557
resolver
ensp
ENSRNOP00000111640
resolver
enst
ENSRNOT00000000696
resolver
genesymbol
Psap
resolver
genesymbol_syn
Sgp1
resolver
uniprot
A0ABZ3NN69
resolver
uniprot
F7EPE0
resolver
uniprot
Q62841
resolver
uniprot
Q64190
resolver
uniprot
Q6P7A4
resolver
uniprot_entry
A0ABZ3NN69_RAT
resolver
uniprot_entry
Q6P7A4_RAT
resolver
uniprot_entry
SAP_RAT
resolver
uniprot_sec
F7EPE0
resolver
uniprot_sec
Q62841
resolver
uniprot_sec
Q64190
resolver
amino_acid_sequence
MYALALLASLLVTALTSPVQDPKICSGGSAVVCRDVKTAVDCRAVKHCQQMVWSKPTAKSLPCDICKTVVTEAGNLLKDNATEEEILHYLEKTCAWIHDSSLSASCKEVVDSYLPVILDMIKGEMSNPGEVCSALNLCQSLQEYLAEQNQRQLESNKIPEVDLARVVAPFMSNIPLLLYPQDRPRSQPQPKANEDVCQDCMKLVTDIQTAVRTNSSFVQGLVDHVKEDCDRLGPGVSDICKNYVDQYSEVAVQMMMHMQPKEICVMVGFCDEVKRVPMRTLVPATEAIKNILPALELTDPYEQDVIQAQNVIFCQVCQLVMRKLSELIINNATEELLIKGLSKACSLLPAPASTKCQEVLVTFGPSLLDVLMHEVNPNFLCGVISLCSANPNLVGTLEQPAAAIVSALPKEPAPPKQPEEPKQSALRAHVPPQKNGGFCEVCKKLVIYLEHNLEKNSTKEEILAALEKGCSFLPDPYQKQCDEFVAEYEPLLLEILVEVMDPSFVCSKIGVCPSAYKLLLGTEKCVWGPGYWCQNSETAARCNAVDHCKRHVWN
uniprot
proteins
function
FUNCTION: Saposins are specific low-molecular mass non-enzymatic glycoproteins that act as activator proteins for lysosomal sphingolipid-degrading enzymes, facilitating the hydrolysis of sphingolipids by extracting lipid substrates from membranes and presenting them to their respective enzymes. They are derived from a common precursor protein, prosaposin, which is proteolytically cleaved to yield four homologous proteins (saposin A, B, C, and D), each with distinct but partially overlapping lipid and enzyme specificities. {ECO:0000250|UniProtKB:P07602}.; FUNCTION: [Prosaposin]: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. {ECO:0000250|UniProtKB:P07602, ECO:0000250|UniProtKB:Q61207}.; FUNCTION: [Saposin-A]: Acts as an essential lysosomal cofactor that activates galactocerebrosidase (GALC, EC 3.2.1.46) by facilitating enzyme access to its membrane-embedded galactosylceramide substrate, the principal lipid component of myelin. {ECO:0000250|UniProtKB:P07602}.; FUNCTION: [Saposin-B]: Stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A ARSA (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. {ECO:0000250|UniProtKB:P07602}.; FUNCTION: [Saposin-C]: Acts as an essential lysosomal cofactor that activates acid beta-glucosylceramidases (EC 3.2.1.45) by altering lipid bilayer properties to facilitate enzyme access to its membrane-embedded glucosylceramide substrate, while also protecting glucocerebrosidase from intralysosomal proteolytic degradation. {ECO:0000250|UniProtKB:P07602}.; FUNCTION: [Saposin-D]: Acts as a lysosomal activator protein that stimulates acid ceramidase (EC 3.5.1.23) by solubilizing and presenting ceramide substrates at the lipid-water interface, facilitating their hydrolysis into sphingosine and fatty acids. It also activates acid sphingomyelinase (EC 3.1.4.12), though ceramide catabolism represents its primary physiological role. {ECO:0000250|UniProtKB:P07602}.
uniprot
proteins
mass_dalton
61124
uniprot
proteins
pubmed
3048385
uniprot
proteins
pubmed
8573994
uniprot
proteins
pubmed
8601692
uniprot
proteins
sequence_length
554
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:P07602}.; SUBCELLULAR LOCATION: [Prosaposin]: Secreted {ECO:0000269|PubMed:3048385, ECO:0000269|PubMed:8573994, ECO:0000269|PubMed:8601692}. Note=Secreted as a fully glycosylated 70 kDa protein composed of complex glycans. {ECO:0000269|PubMed:3048385, ECO:0000269|PubMed:8573994, ECO:0000269|PubMed:8601692}.
uniprot
proteins