TASOR2
entrez
54906
canonical
uniprot
Q5VWN6
canonical
ensembl
ENSG00000108021
resolver
ensp
ENSP00000328426
resolver
ensp
ENSP00000496466
resolver
ensp
ENSP00000512130
resolver
ensp
ENSP00000512206
resolver
ensp
ENSP00000512207
resolver
enst
ENST00000645567
resolver
enst
ENST00000695833
resolver
genesymbol
TASOR2
resolver
genesymbol_syn
C10orf18
resolver
genesymbol_syn
FAM208B
resolver
genesymbol_syn
KIAA2006
resolver
hgnc
HGNC:23484
resolver
uniprot
A0A2R8YH03
resolver
uniprot
A0A8Q3SI84
resolver
uniprot
Q2YD91
resolver
uniprot
Q5VWN5
resolver
uniprot
Q6ZRQ8
resolver
uniprot
Q8IVG4
resolver
uniprot
Q9BUZ7
resolver
uniprot
Q9H5J9
resolver
uniprot
Q9H7A4
resolver
uniprot
Q9H996
resolver
uniprot
Q9NXA1
resolver
uniprot_entry
A0A2R8YH03_HUMAN
resolver
uniprot_entry
A0A8Q3SI84_HUMAN
resolver
uniprot_entry
TASO2_HUMAN
resolver
uniprot_sec
Q2YD91
resolver
uniprot_sec
Q5VWN5
resolver
uniprot_sec
Q6ZRQ8
resolver
uniprot_sec
Q8IVG4
resolver
uniprot_sec
Q9BUZ7
resolver
uniprot_sec
Q9H5J9
resolver
uniprot_sec
Q9H7A4
resolver
uniprot_sec
Q9H996
resolver
uniprot_sec
Q9NXA1
resolver
amino_acid_sequence
MAPPAHKSILERSENVLMSPWKGKLIVQDRMLCDIALWSTYGAMIPTQLPQELDFKYVMKVSSLKKRLPEAAFRKQNYLEEKVCFQDLCFNLYEVELSNRQGENIDKLTECIKNKQLAIIKCLEDRGFFILLTSSALLSEPDFGGKQMGLHGLHLFRSPLSTGVKDLKVEDDISMKVIPILSTLNCALLETKKSLPEERIHPNTLVKRHFQELYKADRSPSLSVAPQDRMKDPTFLGKLPSGFDLIPPAEKCPSESLTQLNSYFSDPSAYILEVSTALDLLAEHPQSPCVSDGICDAGFSLVMTPDPEFLVSEAEVRKETETKKDSEEMLKAKKRVFPLSPASNLRVQPKRKASMPHMVQSKKVNLCRPFPKRTASRADNSSDSPTTLKLVKGQFPQKRKRGAEVLTAQFVQKTKLDRKNQEAPISKDVPVPTNAKRARKQEKSPVKTVPRAKPPVKKSPQKQRVNIVKGNENPRNRKQLQPVKGETASKLQSEISRGCQEDGISINSVQPENTTAAHNDLPENSIVNYDSQALNMLADLALSSATSSTPVSEARNLHCSSELPQNDVLLSKENSLRGTSDHEYHRGVKTQKGELLPNPSSDRKSNSGSDLTVSQDEESLVPCSQAPAKAQSALTEEMLESSDASQSSSVSVEHSYALLLTEHSKKHLQEREILSPLFPRNGTKSPEAATPVGKVMPFRHQPGLLLQQKPPDDPVVKPKDRPPSARVKKSSCSRIVLSCDDSVKITFKCETEYAFSLDSKYTNNPLEKTVVRALHGPWNTDLPDNVEEVKLLLHMWVALFYSNQNKIIRSSRKVVEHSNPAKYVSINSTLESCELREIEESLGLEKCSADSLLETNEISRAHAAEVSFRDPNCLLPFIKTPLTQGLELCVQNEQKKTFARECDPDTQEDQNFICSYNNEVTGEEAKQESLETSNLVLSGIGSTQTNGPSVPSEEEIVQPLDSTRVASYSGTVTQATFTRTYDGPGSQPVICQSSVYGTLENKVDILDAAVQTKTGTLQDLIQHGSPINNECHPSLERKDDNMGCAVINPEPITLTFEKNAHVPIQTEGVNTADERTTFKKELIKQVSPAASLRHPVSTSENARTQGLRDIPSLVVAGQKGTKYLCASSVGGETLDKAVCSLQKETPLPVSLPSDKTMVMEALSLAKSSSHLSPSEEVRCTQDFLSQTQSLLGLSSEGLLELTQVEVDSSSASTTLGRQCSLNCISSGCHTSGDSLELRKNHKNGPNTENMNLEAFDSVFIKQTSLSVSREVSLELSEEDSDIDLALTISPPTSPREEMPAGEIEQFEEAPFSNLELQDVAEEIGEPEEVALTESREVSSADNVSVYPSVSEEPVENKERKGDNLQPVTLILSKENCTLEIAEEINVTSDFPFDSVIEEVSPASSPEPPVPVKETRPYQAVTPCILKLHGTQCEKSNQISQCESEDLGITEKENVFVGPTHPVGQDNFTQVQQMQVSAEMPLILTDHPGRTGRPTLPGKVTEEIVSSEHDEGLSFSGKVQCYGRELNQPASAAKCTGDFSPSPEKLVKSGNPLQPVSIENRNLDLKHLVLESSEPPFGPRNVIENKSLSDTLVSTTAPSGIVNVSVKQQTSPKSSQNHLFPGDLKTDEGIYLQVKSLTAASVDGAYSTQGCMCSVVPTLCSSSDNATLTHYVRPINAEPVFQAQEIPAGRMASLLKNGEPEAELHKETTGPGTAGPQSNTTSSLKGERKAIHTLQDVSTCETKELLNVGVSSLCAGPYQNTADTKENLSKEPLASFVSESFDTSVCGIATEHVEIENSGEGLRAEAGSETLGRDGEVGVNSDMHYELSGDSDLDLLGDCRNPRLDLEDSYTLRGSYTRKKDVPTDGYESSLNFHNNNQEDWGCSSWVPGMETSLPPGHWTAAVKKEEKCVPPYVQIRDLHGILRTYANFSITKELKDTMRTSHGLRRHPSFSANCGLPSSWTSTWQVADDLTQNTLDLEYLRFAHKLKQTIKNGDSQHSASSANVFPKESPTQISIGAFPSTKISEAPFLHPAPRSRSPLLVTVVESDPRPQGQPRRGYTASSLDSSSSWRERCSHNRDLRNSQRNHTVSFHLNKLKYNSTVKESRNDISLILNEYAEFNKVMKNSNQFIFQDKELNDVSGEATAQEMYLPFPGRSASYEDIIIDVCTNLHVKLRSVVKEACKSTFLFYLVETEDKSFFVRTKNLLRKGGHTEIEPQHFCQAFHRENDTLIIIIRNEDISSHLHQIPSLLKLKHFPSVIFAGVDSPGDVLDHTYQELFRAGGFVISDDKILEAVTLVQLKEIIKILEKLNGNGRWKWLLHYRENKKLKEDERVDSTAHKKNIMLKSFQSANIIELLHYHQCDSRSSTKAEILKCLLNLQIQHIDARFAVLLTDKPTIPREVFENSGILVTDVNNFIENIEKIAAPFRSSYW
uniprot
proteins
function
FUNCTION: Core component of the HUSH2 complex, a multiprotein complex that mediates epigenetic repression of interferon-stimulated genes (PubMed:39013473, PubMed:39489739). TASOR2 is recruited to interferon-stimulated genes by IRF2, leading to transcriptional silencing by the HUSH2 complex via a H3K9me3-independent mechanism (PubMed:39013473). Within the HUSH2 complex, TASOR2 acts as the central scaffold, which recruits MPHOSPH8 and PPHLN1 (PubMed:39013473). {ECO:0000269|PubMed:39013473, ECO:0000269|PubMed:39489739}.
uniprot
proteins
mass_dalton
268843
uniprot
proteins
protein_family
TASOR family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
39013473
uniprot
proteins
pubmed
39489739
uniprot
proteins
sequence_length
2430
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:39013473, ECO:0000269|PubMed:39489739}. Chromosome {ECO:0000269|PubMed:39013473, ECO:0000269|PubMed:39489739}. Note=Localizes to interferon-stimulated genes. {ECO:0000269|PubMed:39013473}.
uniprot
proteins