Slc25a1
entrez
13358
canonical
uniprot
Q8JZU2
canonical
ensembl
ENSMUSG00000003528
resolver
ensp
ENSMUSP00000003622
resolver
enst
ENSMUST00000003622
resolver
genesymbol
Slc25a1
resolver
uniprot
Q3TDH6
resolver
uniprot_entry
TXTP_MOUSE
resolver
uniprot_sec
Q3TDH6
resolver
amino_acid_sequence
MAAPRGPRALSAAAPGSGKPKLTHPGKAILAGGLAGGIEICITFPTEYVKTQLQLDERANPPRYRGIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAAVRFGMFEFLSNHMRDAQGRLDSRRGLLCGLGAGVAEAVVVVCPMETIKVKFIHDQTSSNPKYRGFFHGVREIIREQGLKGTYQGLTATVLKQGSNQAIRFFVMTSLRNWYQGDNHNKPMNPLITGVFGATAGAASVFGNTPLDVIKTRMQGLEAHKYRNTLDCGLKILKNEGPKAFYKGTVPRLGRVCLDVAIVFIIYDEVVKLLNKVWKTD
uniprot
proteins
function
FUNCTION: Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extent trans-aconitate, maleate and succinate. Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction. In the cytoplasm, citrate plays important roles in fatty acid and sterol synthesis, regulation of glycolysis, protein acetylation, and other physiopathological processes. {ECO:0000250|UniProtKB:P53007}.
uniprot
proteins
mass_dalton
33931
uniprot
proteins
post_translational_modification
PTM: Possesses a short cleavable presequence, which, however, is found to be dispensable both for targeting to mitochondria and insertion into the inner membrane. However, the presequence is required to keep SLC25A1 in a soluble state and thus in an import-competent state. Mature SLC25A1 lacking the presequence is prone to aggregation. {ECO:0000250|UniProtKB:P32089}.
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
12865426
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18775783
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
311
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:12865426, ECO:0000269|PubMed:18775783}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 29..46; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 86..105; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 129..143; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 183..202; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 224..241; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 278..297; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins