Rab21
entrez
299799
canonical
uniprot
Q6AXT5
canonical
ensembl
ENSRNOG00000003923
resolver
ensembl
ENSRNOG00055012217
resolver
ensembl
ENSRNOG00060010433
resolver
ensembl
ENSRNOG00065013815
resolver
ensp
ENSRNOP00000005258
resolver
ensp
ENSRNOP00055016770
resolver
ensp
ENSRNOP00060013713
resolver
ensp
ENSRNOP00065017623
resolver
enst
ENSRNOT00000005258
resolver
enst
ENSRNOT00055020785
resolver
enst
ENSRNOT00060017644
resolver
enst
ENSRNOT00065022725
resolver
genesymbol
Rab21
resolver
uniprot_entry
RAB21_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) including ANKRD27 and RABGEF1, which promote the exchange of bound GDP for free GTP (By similarity). Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs) (Probable). {ECO:0000250|UniProtKB:Q9UL25, ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MAAAGGGAAAAAGRAYSFKVVLLGEGCVGKTSLVLRYCENKFNDKHITTLQASFLTKKLNIGGKRVNLAIWDTAGQERFHALGPIYYRDSNGAILVYDVTDEDSFQKVKNWVKELRKMLGNEICLCIVGNKIDLEKERHVSIQEAESYAESVGAKHYHTSAKQNKGIEELFLDLCKRMIETAQVDERAKGNGSSQAGAARRGVQIIDDEPQAQSGSGGCCSSG
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB21 is involved in membrane trafficking control (By similarity). Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity). As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (By similarity). Involved in neurite growth (PubMed:19745841). Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (By similarity). Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 (By similarity). {ECO:0000250|UniProtKB:P35282, ECO:0000250|UniProtKB:Q9UL25, ECO:0000269|PubMed:19745841}.
uniprot
proteins
mass_dalton
24163
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19745841
uniprot
proteins
sequence_length
223
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P35282}; Lipid-anchor {ECO:0000305}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:19745841}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P35282}. Early endosome membrane {ECO:0000250|UniProtKB:P35282}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P35282}. Cleavage furrow {ECO:0000250|UniProtKB:P35282}. Cell projection, neuron projection {ECO:0000269|PubMed:19745841}. Note=Colocalizes with ANKRD27 and VAMP7 in neurites (PubMed:19745841). During mitosis, in mid-telophase, localized in the ingressing cleavage furrow (By similarity). In late telophase, detected at the opposite poles of the daughter cells, in vesicles at the base of lamellipodia formed by the separating daughter cells (By similarity). {ECO:0000250|UniProtKB:P35282, ECO:0000269|PubMed:19745841}.
uniprot
proteins