Lrrc7
entrez
242274
canonical
uniprot
Q80TE7
canonical
ensembl
ENSMUSG00000028176
resolver
ensp
ENSMUSP00000101659
resolver
ensp
ENSMUSP00000142440
resolver
ensp
ENSMUSP00000142498
resolver
ensp
ENSMUSP00000143365
resolver
ensp
ENSMUSP00000158628
resolver
enst
ENSMUST00000106044
resolver
enst
ENSMUST00000199890
resolver
enst
ENSMUST00000200137
resolver
enst
ENSMUST00000238317
resolver
genesymbol
Lrrc7
resolver
genesymbol_syn
Kiaa1365
resolver
genesymbol_syn
Lap1
resolver
uniprot
A0A0G2JDN8
resolver
uniprot
A0A0G2JDT9
resolver
uniprot
A0A571BEA5
resolver
uniprot
B9EHV0
resolver
uniprot
E9Q6L9
resolver
uniprot_entry
A0A0G2JDN8_MOUSE
resolver
uniprot_entry
A0A0G2JDT9_MOUSE
resolver
uniprot_entry
A0A571BEA5_MOUSE
resolver
uniprot_entry
B9EHV0_MOUSE
resolver
uniprot_entry
E9Q6L9_MOUSE
resolver
uniprot_entry
LRRC7_MOUSE
resolver
amino_acid_sequence
MTTKRKLIGRLVPCRCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSSLPTSIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFSELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPPTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQRLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQRVLTNYMFPQQPRGDEDFQSDSDSFNPTLWEEQRQQRMTVAFEFEDKKEDDESAGKVKALSCQAPWDRGQRGITLQPARLSGDCCTPWARCDQQIQDMPVPQSDPQLAWGCISGLQQERSMCAPLPVAAQSTTLPSLSGRQVEINLKRYPTPYPEDLKNMVKSVQNLVGKPSHGVRVENSNPTANTEQTVKEKFEHKWPVAPKEITVEDSFVHPANEMRIGELHPSLAETPLYPPKLVLLGKDKKESTDESEVDKTHCLNNSVSSGTYSDYSPSQASSASSNTRMKVGSLQATAKDAVHNSLWGNRIAPPFPQPLDAKPLLSQREAVPPGNIPQRPDRLPMSDAFPDNWTDGSHYDNTGFVSEEAAGENANNNPLLSSKARSVPAHGRRPLIRQERIVGVPLELEQSTHRHTPETEVPPSNPWQNWTRTPSPFEDRTAFPSKLETTPTTSPLPERKDHMKEPTETPGPFSPGVPWEYHDPTPNRSLGNVFSQIHCRPDSSKGVIAISKSTERLSPLMKDIKSNKFKKSQSIDEIDVGTYKVYNIPLENYASGSDHLGSHERPDKFLGPEHGMSSMSRSQSVPMLDDEMLMYGSSKGPPQQKASMTKKVYQFDQSFNPQGAVEVKAEKRIPPPFAHNSEYVQQPSKNIAKDLVSPRAYRGYPPMEQMFSFSQPSVNEDAMVNAQFASQGPRAGFLRRADSLASSTEMAMFRRVSEPHELPPGDRYGRATYRGGLEGQSSISMTDPQFLKRNGRYEDEHPSYQEVKAQAGSFPAKNLTQRRPLSARSYSTESYGASQTRPVSARPTMAALLEKIPSDYNLGNYGDKTSDNSDIKTRPTPVKGEESCGKMPADWRQQLLRHIEARRLDRTPSQQSNILDNGQEDVSPSGQWNPYPLGRRDVPPDTITKKAGSHIQTLMGSQSLQHRSREQQPYEGNINKVTIQQFQSPLPIQIPSSQATRGPQPGRCLIQTKGQRSMDGYPEQFCVRIEKNPGLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNLLQPGDKILQANGHSFVHMEHEKAVLLLKSFQNTVDLVIQRELTV
uniprot
proteins
function
FUNCTION: Adapter protein that is required for correct postsynapse architecture and regulates postsynaptic plasticity through interactions with different partners (By similarity). Through its interaction with CACNA1C, it enhances trafficking of voltage-dependent L-type calcium channels to the dendritic cell membrane and increases channel postsynaptic clustering, thereby facilitating excitatory calcium signaling (PubMed:28363979). It also serves as a scaffold that brings CAMK2A and PPP1CA into close proximity, probably facilitating rapid dephosphorylation of CAMK2A by PPP1CA and influencing CAMK2A-mediated regulation of postsynaptic plasticity (By similarity). Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term synaptic depression (PubMed:22072671). {ECO:0000250|UniProtKB:Q96NW7, ECO:0000269|PubMed:22072671, ECO:0000269|PubMed:28363979}.
uniprot
proteins
mass_dalton
166901
uniprot
proteins
protein_family
LAP (LRR and PDZ) protein family
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22072671
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
28363979
uniprot
proteins
pubmed
39256359
uniprot
proteins
sequence_length
1490
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96NW7}. Postsynaptic density {ECO:0000269|PubMed:22072671, ECO:0000269|PubMed:39256359}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q96NW7}. Postsynapse {ECO:0000250|UniProtKB:Q96NW7}.
uniprot
proteins