IFT20
entrez
90410
canonical
uniprot
Q8IY31
canonical
ensembl
ENSG00000109083
resolver
ensp
ENSP00000350570
resolver
ensp
ENSP00000378809
resolver
ensp
ENSP00000463138
resolver
ensp
ENSP00000463322
resolver
ensp
ENSP00000464443
resolver
ensp
ENSP00000484842
resolver
enst
ENST00000588477
resolver
genesymbol
IFT20
resolver
hgnc
HGNC:30989
resolver
uniprot
A0A087X2B4
resolver
uniprot
J3QL09
resolver
uniprot
Q5GLZ2
resolver
uniprot
Q9BUG5
resolver
uniprot_entry
A0A087X2B4_HUMAN
resolver
uniprot_entry
IFT20_HUMAN
resolver
uniprot_sec
J3QL09
resolver
uniprot_sec
Q5GLZ2
resolver
uniprot_sec
Q9BUG5
resolver
amino_acid_sequence
MAKDILGEAGLHFDELNKLRVLDPEVTQQTIELKEECKDFVDKIGQFQKIVGGLIELVDQLAKEAENEKMKAIGARNLLKSIAKQREAQQQQLQALIAEKKMQLERYRVEYEALCKVEAEQNEFIDQFIFQK
uniprot
proteins
function
FUNCTION: Part of intraflagellar transport (IFT) particles involved in ciliary process assembly (PubMed:17604723). May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium (PubMed:16775004). Regulates the platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Required for protein stability of E3 ubiquitin ligases CBL and CBLB that mediate ubiquitination and internalization of PDGFRA for proper feedback inhibition of PDGFRA signaling (PubMed:29237719). Essential for male fertility. Plays an important role in spermatogenesis, particularly spermiogenesis, when germ cells form flagella. May play a role in the transport of flagellar proteins ODF2 and SPAG16 to build sperm flagella and in the removal of redundant sperm cytoplasm (By similarity). Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment (By similarity). {ECO:0000250|UniProtKB:Q61025, ECO:0000269|PubMed:16775004, ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:29237719}.
uniprot
proteins
mass_dalton
15281
uniprot
proteins
pubmed
12107411
uniprot
proteins
pubmed
14672413
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16775004
uniprot
proteins
pubmed
17604723
uniprot
proteins
pubmed
19112494
uniprot
proteins
pubmed
19889948
uniprot
proteins
pubmed
23530209
uniprot
proteins
pubmed
29237719
uniprot
proteins
pubmed
30929735
uniprot
proteins
pubmed
31637240
uniprot
proteins
sequence_length
132
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000250|UniProtKB:Q61025}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q61025}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q61025}. Cell projection, cilium {ECO:0000250|UniProtKB:Q61025}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q61025}. Golgi apparatus {ECO:0000250|UniProtKB:Q61025}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q61025}. Cytoplasm {ECO:0000250|UniProtKB:Q61025}. Note=Present at the centrosomes during the cell cycle and associated with the proximal portion of the mother centriole and the lateral aspect of the daughter centriole. Associated with basal body at the base of primary cilia. Detected in the Golgi apparatus of round spermatids and late spermatocytes. Also detected in the manchette of step 10-12 spermatids. In step 14 spermatids, found in the basal body of the sperm tail. Localization in the manchette of elongating spermatids is dependent on SPAG17. {ECO:0000250|UniProtKB:Q61025}.
uniprot
proteins