BRD7
entrez
29117
canonical
uniprot
Q9NPI1
canonical
ensembl
ENSG00000166164
resolver
ensp
ENSP00000378180
resolver
ensp
ENSP00000378181
resolver
ensp
ENSP00000518227
resolver
enst
ENST00000710356
resolver
genesymbol
BRD7
resolver
genesymbol_syn
BP75
resolver
genesymbol_syn
CELTIX1
resolver
hgnc
HGNC:14310
resolver
uniprot
A0AA34QVS2
resolver
uniprot
Q4VC09
resolver
uniprot
Q8N2L9
resolver
uniprot
Q96KA4
resolver
uniprot
Q9BV48
resolver
uniprot
Q9UH59
resolver
uniprot_entry
A0AA34QVS2_HUMAN
resolver
uniprot_entry
BRD7_HUMAN
resolver
uniprot_sec
Q4VC09
resolver
uniprot_sec
Q8N2L9
resolver
uniprot_sec
Q96KA4
resolver
uniprot_sec
Q9BV48
resolver
uniprot_sec
Q9UH59
resolver
amino_acid_sequence
MGKKHKKHKSDKHLYEEYVEKPLKLVLKVGGNEVTELSTGSSGHDSSLFEDKNDHDKHKDRKRKKRKKGEKQIPGEEKGRKRRRVKEDKKKRDRDRVENEAEKDLQCHAPVRLDLPPEKPLTSSLAKQEEVEQTPLQEALNQLMRQLQRKDPSAFFSFPVTDFIAPGYSMIIKHPMDFSTMKEKIKNNDYQSIEELKDNFKLMCTNAMIYNKPETIYYKAAKKLLHSGMKILSQERIQSLKQSIDFMADLQKTRKQKDGTDTSQSGEDGGCWQREREDSGDAEAHAFKSPSKENKKKDKDMLEDKFKSNNLEREQEQLDRIVKESGGKLTRRLVNSQCEFERRKPDGTTTLGLLHPVDPIVGEPGYCPVRLGMTTGRLQSGVNTLQGFKEDKRNKVTPVLYLNYGPYSSYAPHYDSTFANISKDDSDLIYSTYGEDSDLPSDFSIHEFLATCQDYPYVMADSLLDVLTKGGHSRTLQEMEMSLPEDEGHTRTLDTAKEMEITEVEPPGRLDSSTQDRLIALKAVTNFGVPVEVFDSEEAEIFQKKLDETTRLLRELQEAQNERLSTRPPPNMICLLGPSYREMHLAEQVTNNLKELAQQVTPGDIVSTYGVRKAMGISIPSPVMENNFVDLTEDTEEPKKTDVAECGPGGS
uniprot
proteins
function
FUNCTION: Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase. {ECO:0000250, ECO:0000269|PubMed:16265664, ECO:0000269|PubMed:16475162, ECO:0000269|PubMed:20215511, ECO:0000269|PubMed:20228809, ECO:0000269|PubMed:20660729}.
uniprot
proteins
mass_dalton
74139
uniprot
proteins
pubmed
11025449
uniprot
proteins
pubmed
12489984
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
16265664
uniprot
proteins
pubmed
16475162
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17498659
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20215511
uniprot
proteins
pubmed
20228809
uniprot
proteins
pubmed
20660729
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25593309
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
651
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16265664, ECO:0000269|PubMed:16475162, ECO:0000269|PubMed:20228809, ECO:0000269|PubMed:25593309}. Chromosome {ECO:0000269|PubMed:16265664}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:11025449}.
uniprot
proteins