MAPK9
entrez
5601
canonical
uniprot
P45984
canonical
ensembl
ENSG00000050748
resolver
ensp
ENSP00000345524
resolver
ensp
ENSP00000377028
resolver
ensp
ENSP00000389338
resolver
ensp
ENSP00000394560
resolver
ensp
ENSP00000397422
resolver
ensp
ENSP00000443149
resolver
ensp
ENSP00000728589
resolver
enst
ENST00000539014
resolver
genesymbol
MAPK9
resolver
genesymbol_syn
JNK2
resolver
genesymbol_syn
PRKM9
resolver
genesymbol_syn
SAPK1A
resolver
hgnc
HGNC:6886
resolver
uniprot
A8K0S3
resolver
uniprot
B5BU66
resolver
uniprot
B5M0B4
resolver
uniprot
D3DWQ8
resolver
uniprot
D3DWQ9
resolver
uniprot
D7R525
resolver
uniprot
F6XI87
resolver
uniprot
Q15708
resolver
uniprot
Q15710
resolver
uniprot
Q15711
resolver
uniprot
Q8N5C5
resolver
uniprot_entry
D7R525_HUMAN
resolver
uniprot_entry
F6XI87_HUMAN
resolver
uniprot_entry
MK09_HUMAN
resolver
uniprot_sec
A8K0S3
resolver
uniprot_sec
B5BU66
resolver
uniprot_sec
B5M0B4
resolver
uniprot_sec
D3DWQ8
resolver
uniprot_sec
D3DWQ9
resolver
uniprot_sec
Q15708
resolver
uniprot_sec
Q15710
resolver
uniprot_sec
Q15711
resolver
uniprot_sec
Q8N5C5
resolver
activity_regulation
ACTIVITY REGULATION: Activated by threonine and tyrosine phosphorylation by either of two dual specificity kinases, MAP2K4 and MAP2K7. MAP2K4 shows a strong preference for Tyr-185 while MAP2K7 phosphorylates Tyr-183 preferentially. Inhibited by dual specificity phosphatases, such as DUSP1. {ECO:0000269|PubMed:11062067}.
uniprot
proteins
amino_acid_sequence
MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPLEGCR
uniprot
proteins
ec_number
2.7.11.24
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death (PubMed:10376527, PubMed:15805466, PubMed:17525747, PubMed:19675674, PubMed:20595622, PubMed:21364637, PubMed:22441692, PubMed:34048572). Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK9/JNK2 (PubMed:10376527, PubMed:15805466, PubMed:17525747, PubMed:19675674, PubMed:20595622, PubMed:21364637, PubMed:22441692, PubMed:34048572). In turn, MAPK9/JNK2 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity (PubMed:10376527). In response to oxidative or ribotoxic stresses, inhibits rRNA synthesis by phosphorylating and inactivating the RNA polymerase 1-specific transcription initiation factor RRN3 (PubMed:15805466). Promotes stressed cell apoptosis by phosphorylating key regulatory factors including TP53 and YAP1 (PubMed:17525747, PubMed:21364637). In T-cells, MAPK8 and MAPK9 are required for polarized differentiation of T-helper cells into Th1 cells (PubMed:19290929). Upon T-cell receptor (TCR) stimulation, is activated by CARMA1, BCL10, MAP2K7 and MAP3K7/TAK1 to regulate JUN protein levels (PubMed:19290929). Plays an important role in the osmotic stress-induced epithelial tight-junctions disruption (PubMed:20595622). When activated, promotes beta-catenin/CTNNB1 degradation and inhibits the canonical Wnt signaling pathway (PubMed:19675674). Also participates in neurite growth in spiral ganglion neurons (By similarity). Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the regulation of the circadian clock (PubMed:22441692). Phosphorylates POU5F1, which results in the inhibition of POU5F1's transcriptional activity and enhances its proteasomal degradation (By similarity). Phosphorylates ALKBH5 in response to reactive oxygen species (ROS), promoting ALKBH5 sumoylation and inactivation (PubMed:34048572). {ECO:0000250|UniProtKB:Q9WTU6, ECO:0000269|PubMed:10376527, ECO:0000269|PubMed:15805466, ECO:0000269|PubMed:17525747, ECO:0000269|PubMed:19675674, ECO:0000269|PubMed:20595622, ECO:0000269|PubMed:21364637, ECO:0000269|PubMed:22441692, ECO:0000269|PubMed:34048572, ECO:0000303|PubMed:19290929}.; FUNCTION: MAPK9 isoforms display different binding patterns: alpha-1 and alpha-2 preferentially bind to JUN, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 alpha-2, and JUND binds only weakly to it.
uniprot
proteins
mass_dalton
48139
uniprot
proteins
post_translational_modification
PTM: Dually phosphorylated on Thr-183 and Tyr-185 by MAP2K7 and MAP2K4, which activates the enzyme. Autophosphorylated in vitro. {ECO:0000269|PubMed:11062067}.
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
MAP kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10376527
uniprot
proteins
pubmed
11062067
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15693750
uniprot
proteins
pubmed
15805466
uniprot
proteins
pubmed
17189706
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17525747
uniprot
proteins
pubmed
17875713
uniprot
proteins
pubmed
18801372
uniprot
proteins
pubmed
19054851
uniprot
proteins
pubmed
19290929
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19675674
uniprot
proteins
pubmed
20595622
uniprot
proteins
pubmed
21110917
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21364637
uniprot
proteins
pubmed
22441692
uniprot
proteins
pubmed
28089251
uniprot
proteins
pubmed
28157543
uniprot
proteins
pubmed
34048572
uniprot
proteins
pubmed
7969172
uniprot
proteins
pubmed
8001819
uniprot
proteins
pubmed
8654373
uniprot
proteins
sequence_length
424
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19675674}. Nucleus {ECO:0000269|PubMed:19675674}. Note=Colocalizes with POU5F1 in the nucleus. {ECO:0000250|UniProtKB:Q9WTU6}.
uniprot
proteins