Pip4k2b
entrez
89812
canonical
uniprot
O88377
canonical
ensembl
ENSRNOG00000013030
resolver
ensembl
ENSRNOG00055032651
resolver
ensembl
ENSRNOG00060026321
resolver
ensembl
ENSRNOG00065031143
resolver
ensp
ENSRNOP00000017989
resolver
ensp
ENSRNOP00055046531
resolver
ensp
ENSRNOP00060037842
resolver
ensp
ENSRNOP00065044137
resolver
enst
ENSRNOT00000017989
resolver
enst
ENSRNOT00055056425
resolver
enst
ENSRNOT00060045585
resolver
enst
ENSRNOT00065053691
resolver
genesymbol
Pip4k2b
resolver
genesymbol_syn
Pip5k2b
resolver
uniprot_entry
PI42B_RAT
resolver
amino_acid_sequence
MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLRVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEETEVEDRAEEEECENDGVGGGLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESAPKKEVYFMAIIDILTPYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT
uniprot
proteins
ec_number
2.7.1.149
uniprot
proteins
function
FUNCTION: Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate (PubMed:9685379). Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration. Its GTP-sensing activity is critical for metabolic adaptation (By similarity). PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (By similarity). {ECO:0000250|UniProtKB:P78356, ECO:0000269|PubMed:9685379}.
uniprot
proteins
mass_dalton
47264
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the SPOP/CUL3 complex. Ubiquitination is stimulated by PtdIns5P levels. {ECO:0000250|UniProtKB:P78356}.; PTM: Phosphorylated on serine residues. {ECO:0000250|UniProtKB:P78356}.
uniprot
proteins
pubmed
9685379
uniprot
proteins
sequence_length
416
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Associated with the plasma membrane and the endoplasmic reticulum. {ECO:0000250}.
uniprot
proteins