Trub2
entrez
227682
canonical
uniprot
Q91WG3
canonical
ensembl
ENSMUSG00000039826
resolver
ensp
ENSMUSP00000041848
resolver
ensp
ENSMUSP00000135521
resolver
ensp
ENSMUSP00000316259
resolver
ensp
ENSMUSP00000316262
resolver
enst
ENSMUST00000048044
resolver
enst
ENSMUST00000177467
resolver
genesymbol
Trub2
resolver
uniprot
H3BKT7
resolver
uniprot
Q8BTK3
resolver
uniprot_entry
H3BKT7_MOUSE
resolver
uniprot_entry
TRUB2_MOUSE
resolver
uniprot_sec
Q8BTK3
resolver
amino_acid_sequence
MGSSGLARLQGLFAVYKPPGLKWLHLRETVELQLLKGLNAQQPPAPDQRVRFLLGPVEGSEEKKLTLRATNVPSLTTHRLVRGPAFTNLKIGVGHRLDVQASGVLVLAVGHGRSLLTDMYDAHLTKDYTVRGLLGKATDNFCEDGRLIEKTTYDHVTRERLDRILAVIQGSHQKALVMYSNLDLKSQEAYEMAVQGVIRPMNKSPMLISGIRCLHFAPPEFLLEVQCMHETQQQLRKLVHEIGLELKTSAVCTQVRRTRDGFFGLDDALLRTQWDLHNIQDAIQAAAPRVAAELQKNLSLKLGHHQLPSTGQPWGLKDPSSTLELESCSGQ
uniprot
proteins
ec_number
5.4.99.-
uniprot
proteins
ec_number
5.4.99.25
uniprot
proteins
function
FUNCTION: Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs) such as COXI and COXIII mt-mRNAs. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation. Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs. {ECO:0000250|UniProtKB:O95900}.
uniprot
proteins
mass_dalton
36807
uniprot
proteins
protein_family
Pseudouridine synthase TruB family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
331
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:O95900}. Note=Localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly. {ECO:0000250|UniProtKB:O95900}.
uniprot
proteins