C0HMG9
uniprot
C0HMG9
canonical
amino_acid_sequence
MRAKFVIAQNQDVRLMQKITPFQRESFHLTSLELRARGATWPKAGLAKVVEKSPGSCRSRQRRNPRFCAELATVSGSMCAWDLDSSP
uniprot
proteins
function
FUNCTION: Acts as a cytoplasmic regulator of pluripotency and embryonic development (PubMed:41298451). Promotes the transition from the naive to the primed pluripotency state and safeguards the primed state (PubMed:41298451). Promotes L1TD1 condensate formation and prevents L1TD1 from binding and stabilizing transcripts of the pluripotency regulator TFCP2L1 (By similarity). Stabilizes P-bodies in epiblast stem cells which are enriched with nuclear-encoded mitochondrial mRNAs, thereby promoting degradation of the mRNAs (By similarity). Controls metabolic remodeling during embryo implantation by regulating mitochondrial oxidative phosphorylation (By similarity). {ECO:0000250|UniProtKB:C0HMG8, ECO:0000269|PubMed:41298451}.
uniprot
proteins
mass_dalton
9808
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
41298451
uniprot
proteins
sequence_length
87
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:C0HMG8}. Cytoplasm, P-body {ECO:0000250|UniProtKB:C0HMG8}. Note=Exhibits punctate cytoplasmic localization. Shows partial colocalization with P-bodies. {ECO:0000250|UniProtKB:C0HMG8}.
uniprot
proteins