Syt7
entrez
54525
canonical
uniprot
Q9R0N7
canonical
ensembl
ENSMUSG00000024743
resolver
ensp
ENSMUSP00000073560
resolver
ensp
ENSMUSP00000076234
resolver
ensp
ENSMUSP00000127973
resolver
ensp
ENSMUSP00000153132
resolver
ensp
ENSMUSP00000153482
resolver
ensp
ENSMUSP00000158359
resolver
enst
ENSMUST00000076968
resolver
enst
ENSMUST00000169121
resolver
enst
ENSMUST00000235784
resolver
genesymbol
Syt7
resolver
uniprot
A0A2C9F2C1
resolver
uniprot
A0A494BB44
resolver
uniprot
A0A498WGM0
resolver
uniprot
A4QPF1
resolver
uniprot
E9PZA8
resolver
uniprot
Q0D2K7
resolver
uniprot
Q8CF95
resolver
uniprot
Q8CF96
resolver
uniprot_entry
A0A2C9F2C1_MOUSE
resolver
uniprot_entry
A0A494BB44_MOUSE
resolver
uniprot_entry
A0A498WGM0_MOUSE
resolver
uniprot_entry
SYT7_MOUSE
resolver
uniprot_sec
A4QPF1
resolver
uniprot_sec
E9PZA8
resolver
uniprot_sec
Q0D2K7
resolver
uniprot_sec
Q8CF95
resolver
uniprot_sec
Q8CF96
resolver
amino_acid_sequence
MYRDPEAASPGAPTRDVLLVSAIITVSLSVTIVLCGLCHWCQRKLGKRYKNSLETVGTPDSGRGRGEKKAIKLPAGGKAVNTAPVPGQTPHDESDRRTETRSSVSDLVNSLTSEMLMLSPGSEEDEAHEGCSRENLGRIQFSVGYNFQESTLTVKVMKAQELPAKDFSGTSDPFVKIYLLPDKKHKLETKVKRKNLNPHWNETFLFEGFPYEKVVQRVLYLQVLDYDRFSRNDPIGEVSIPLNKVDLTQMQTFWKDLKPCSDGSGSRGELLLSLCYNPSANSIIVNIIKARNLKAMDIGGTSDPYVKVWLMYKDKRVEKKKTVTKKRNLNPIFNESFAFDIPTEKLRETTIIITVMDKDKLSRNDVIGKIYLSWKSGPGEVKHWKDMIARPRQPVAQWHQLKA
uniprot
proteins
function
FUNCTION: Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis. SYT7 binds Ca(2+) with high affinity and slow kinetics compared to other synaptotagmins (PubMed:26738595). Involved in Ca(2+)-triggered lysosomal exocytosis, a major component of the plasma membrane repair (By similarity). Ca(2+)-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages (PubMed:16982801, PubMed:21041449). Ca(2+)-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts (PubMed:18539119). Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes (PubMed:25860611). Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca(2+) into the axon terminal after spike generation, increasing the release probability of neurotransmitters (PubMed:24569478, PubMed:26738595). Probably mediates synaptic facilitation by directly increasing the probability of release (PubMed:26738595). May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca(2+) and by forming a complex with calmodulin (PubMed:24569478). Also acts as a regulator of Ca(2+)-dependent insulin and glucagon secretion in beta-cells (PubMed:18308938, PubMed:19171650). Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells (PubMed:20956309). Also regulates the secretion of some non-synaptic secretory granules of specialized cells (By similarity). {ECO:0000250|UniProtKB:Q62747, ECO:0000269|PubMed:16982801, ECO:0000269|PubMed:18308938, ECO:0000269|PubMed:18539119, ECO:0000269|PubMed:19171650, ECO:0000269|PubMed:20956309, ECO:0000269|PubMed:21041449, ECO:0000269|PubMed:24569478, ECO:0000269|PubMed:25860611, ECO:0000269|PubMed:26738595}.
uniprot
proteins
mass_dalton
45472
uniprot
proteins
mutagenesis
MUTAGEN 35..41; /note="CGLCHWC->SGLSHWS: Abolishes palmitoylation. Impaired phagocytosis and localization to lysosomes."; /evidence="ECO:0000269|PubMed:21041449"; MUTAGEN 225..233; /note="DYDRFSRND->AYARFSRNA: In C2A*; loss of function due to abolished Ca(2+)-binding to the first C2 domain. Impaired ability to mediate synaptic facilitation."; /evidence="ECO:0000269|PubMed:26738595"; MUTAGEN 225..227; /note="DYD->NYN: Loss of Ca(2+)-binding in the first C2 domain. Impaired delivery of lysosomal membrane to nascent phagosomes; when associated with 357-N--N-359. Impaired synaptic vesicle replenishment; when associated with 357-N--N-359."; /evidence="ECO:0000269|PubMed:16982801, ECO:0000269|PubMed:24569478"; MUTAGEN 357..359; /note="DKD->NKN: Loss of Ca(2+)-binding in the second C2 domain. Impaired delivery of lysosomal membrane to nascent phagosomes; when associated with 225-N--N-227. Impaired synaptic vesicle replenishment; when associated with 225-N--N-227."; /evidence="ECO:0000269|PubMed:16982801, ECO:0000269|PubMed:24569478
uniprot
proteins
post_translational_modification
PTM: Palmitoylated at its vesicular N-terminus; palmitoylation is required for localization to lysosome and phagocytosis in macrophages. {ECO:0000269|PubMed:21041449}.
uniprot
proteins
protein_family
Synaptotagmin family
uniprot
proteins
pubmed
10531343
uniprot
proteins
pubmed
10871604
uniprot
proteins
pubmed
11395007
uniprot
proteins
pubmed
12071850
uniprot
proteins
pubmed
12925704
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16982801
uniprot
proteins
pubmed
17720139
uniprot
proteins
pubmed
18308938
uniprot
proteins
pubmed
18539119
uniprot
proteins
pubmed
19171650
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20824061
uniprot
proteins
pubmed
20956309
uniprot
proteins
pubmed
21041449
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24569478
uniprot
proteins
pubmed
25860611
uniprot
proteins
pubmed
26738595
uniprot
proteins
pubmed
30429473
uniprot
proteins
sequence_length
403
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q62747}; Single-pass membrane protein {ECO:0000255}. Presynaptic cell membrane {ECO:0000269|PubMed:11395007}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:24569478}; Single-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:21041449, ECO:0000269|PubMed:25860611}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:16982801}; Single-pass membrane protein {ECO:0000255}. Peroxisome membrane {ECO:0000269|PubMed:25860611}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q62747}; Single-pass membrane protein {ECO:0000255}. Note=Localization to lysosomes is dependent on N-terminal palmitoylation and interaction with CD63. {ECO:0000269|PubMed:21041449}.
uniprot
proteins
transmembrane_region
TRANSMEM 17..37; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins