CDC23
entrez
8697
canonical
uniprot
Q9UJX2
canonical
ensembl
ENSG00000094880
resolver
ensp
ENSP00000378350
resolver
genesymbol
CDC23
resolver
genesymbol_syn
ANAPC8
resolver
hgnc
HGNC:1724
resolver
uniprot
A8K6E5
resolver
uniprot
B4E3A2
resolver
uniprot
B7WP05
resolver
uniprot
D3DQB7
resolver
uniprot
O75433
resolver
uniprot
Q53FN2
resolver
uniprot
Q9BS73
resolver
uniprot_entry
CDC23_HUMAN
resolver
uniprot_sec
A8K6E5
resolver
uniprot_sec
B4E3A2
resolver
uniprot_sec
B7WP05
resolver
uniprot_sec
D3DQB7
resolver
uniprot_sec
O75433
resolver
uniprot_sec
Q53FN2
resolver
uniprot_sec
Q9BS73
resolver
amino_acid_sequence
MAASTSMVPVAVTAAVAPVLSINSDFSDLREIKKQLLLIAGLTRERGLLHSSKWSAELAFSLPALPLAELQPPPPITEEDAQDMDAYTLAKAYFDVKEYDRAAHFLHGCNSKKAYFLYMYSRYLSGEKKKDDETVDSLGPLEKGQVKNEALRELRVELSKKHQARELDGFGLYLYGVVLRKLDLVKEAIDVFVEATHVLPLHWGAWLELCNLITDKEMLKFLSLPDTWMKEFFLAHIYTELQLIEEALQKYQNLIDVGFSKSSYIVSQIAVAYHNIRDIDKALSIFNELRKQDPYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQLTESEQAAQCYIKYIQDIYSCGEIVEHLEESTAFRYLAQYYFKCKLWDEASTCAQKCCAFNDTREEGKALLRQILQLRNQGETPTTEVPAPFFLPASLSANNTPTRRVSPLNLSSVTP
uniprot
proteins
function
FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (PubMed:18485873, PubMed:27120157, PubMed:27509861). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:18485873). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (PubMed:27120157, PubMed:27509861). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (PubMed:27509861). {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:27120157, ECO:0000269|PubMed:27509861, ECO:0000269|PubMed:29033132}.
uniprot
proteins
mass_dalton
68834
uniprot
proteins
mutagenesis
MUTAGEN 339; /note="N->A: Inhibits APC/FZR1 E3 ubiquitin-protein ligase complex activity; when associated with A-374."; /evidence="ECO:0000269|PubMed:26083744"; MUTAGEN 374; /note="E->A: Inhibits APC/FZR1 E3 ubiquitin-protein ligase complex activity; when associated with A-339."; /evidence="ECO:0000269|PubMed:26083744
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation on Thr-562 occurs specifically during mitosis. {ECO:0000269|PubMed:14657031}.
uniprot
proteins
protein_family
APC8/CDC23 family
uniprot
proteins
pubmed
14657031
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16364912
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
18485873
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21307936
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25043029
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
26083744
uniprot
proteins
pubmed
27120157
uniprot
proteins
pubmed
27509861
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
29033132
uniprot
proteins
pubmed
34595750
uniprot
proteins
pubmed
9469815
uniprot
proteins
pubmed
9790767
uniprot
proteins
sequence_length
597
uniprot
proteins