CNR2
entrez
1269
canonical
uniprot
P34972
canonical
ensembl
ENSG00000188822
resolver
ensp
ENSP00000363596
resolver
enst
ENST00000374472
resolver
genesymbol
CNR2
resolver
genesymbol_syn
CB2A
resolver
genesymbol_syn
CB2B
resolver
hgnc
HGNC:2160
resolver
uniprot
C6ES44
resolver
uniprot
Q4VBK8
resolver
uniprot
Q5JRH7
resolver
uniprot
Q6B0G7
resolver
uniprot
Q6NSY0
resolver
uniprot_entry
CNR2_HUMAN
resolver
uniprot_sec
C6ES44
resolver
uniprot_sec
Q4VBK8
resolver
uniprot_sec
Q5JRH7
resolver
uniprot_sec
Q6B0G7
resolver
uniprot_sec
Q6NSY0
resolver
amino_acid_sequence
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCSELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYALRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
uniprot
proteins
function
FUNCTION: Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis. {ECO:0000269|PubMed:10051546, ECO:0000269|PubMed:12663043, ECO:0000269|PubMed:12711605, ECO:0000269|PubMed:18692962}.
uniprot
proteins
mass_dalton
39681
uniprot
proteins
mutagenesis
MUTAGEN 109; /note="K->A: No effect on agonist binding. Affects cannabinoid agonist binding; when associated with G-112."; /evidence="ECO:0000269|PubMed:10051546"; MUTAGEN 109; /note="K->R: No effect on agonist binding."; /evidence="ECO:0000269|PubMed:10051546"; MUTAGEN 112; /note="S->G: Affects cannabinoid agonist binding; when associated with A-109."; /evidence="ECO:0000269|PubMed:10051546"; MUTAGEN 130; /note="D->A: Loss of ligand binding. Alters agonist-induced inhibitory effect on adenylate cyclase."; /evidence="ECO:0000269|PubMed:12663043"; MUTAGEN 131; /note="R->A: No effect on ligand binding. Alters agonist-induced inhibitory effect on adenylate cyclase."; /evidence="ECO:0000269|PubMed:12663043"; MUTAGEN 201; /note="L->P: Abolishes ligand binding and agonist-induced inhibitory effect on adenylate cyclase."; /evidence="ECO:0000269|PubMed:12417328"; MUTAGEN 207; /note="Y->A: Abolishes agonist-induced inhibitory effect on adenylate cyclase. No effect on ligand binding."; /evidence="ECO:0000269|PubMed:12417328"; MUTAGEN 244; /note="A->E: Loss of ligand binding. Alters agonist-induced inhibitory effect on adenylate cyclase."; /evidence="ECO:0000269|PubMed:12663043
uniprot
proteins
post_translational_modification
PTM: Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor. {ECO:0000269|PubMed:10400664}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10051546
uniprot
proteins
pubmed
10400664
uniprot
proteins
pubmed
10617657
uniprot
proteins
pubmed
12153574
uniprot
proteins
pubmed
12417328
uniprot
proteins
pubmed
12511587
uniprot
proteins
pubmed
12663043
uniprot
proteins
pubmed
12711605
uniprot
proteins
pubmed
14657172
uniprot
proteins
pubmed
15266552
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18286196
uniprot
proteins
pubmed
18692962
uniprot
proteins
pubmed
19397896
uniprot
proteins
pubmed
19496827
uniprot
proteins
pubmed
23955712
uniprot
proteins
pubmed
7556170
uniprot
proteins
pubmed
7689702
uniprot
proteins
sequence_length
360
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000250}. Perikaryon {ECO:0000250}. Note=Localizes to apical dendrite of pyramidal neurons. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..59; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 72..92; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 105..129; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 150..172; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 189..214; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 247..267; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 280..301; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins