TRIM38
entrez
10475
canonical
uniprot
O00635
canonical
ensembl
ENSG00000112343
resolver
ensp
ENSP00000349596
resolver
ensp
ENSP00000529192
resolver
ensp
ENSP00000529193
resolver
ensp
ENSP00000529195
resolver
ensp
ENSP00000529198
resolver
ensp
ENSP00000529199
resolver
ensp
ENSP00000529200
resolver
ensp
ENSP00000787307
resolver
enst
ENST00000357085
resolver
enst
ENST00000859133
resolver
enst
ENST00000859134
resolver
enst
ENST00000859136
resolver
enst
ENST00000859139
resolver
enst
ENST00000859140
resolver
enst
ENST00000859141
resolver
genesymbol
TRIM38
resolver
genesymbol_syn
RNF15
resolver
genesymbol_syn
RORET
resolver
hgnc
HGNC:10059
resolver
uniprot
B2R862
resolver
uniprot_entry
TRI38_HUMAN
resolver
uniprot_sec
B2R862
resolver
amino_acid_sequence
MASTTSTKKMMEEATCSICLSLMTNPVSINCGHSYCHLCITDFFKNPSQKQLRQETFCCPQCRAPFHMDSLRPNKQLGSLIEALKETDQEMSCEEHGEQFHLFCEDEGQLICWRCERAPQHKGHTTALVEDVCQGYKEKLQKAVTKLKQLEDRCTEQKLSTAMRITKWKEKVQIQRQKIRSDFKNLQCFLHEEEKSYLWRLEKEEQQTLSRLRDYEAGLGLKSNELKSHILELEEKCQGSAQKLLQNVNDTLSRSWAVKLETSEAVSLELHTMCNVSKLYFDVKKMLRSHQVSVTLDPDTAHHELILSEDRRQVTRGYTQENQDTSSRRFTAFPCVLGCEGFTSGRRYFEVDVGEGTGWDLGVCMENVQRGTGMKQEPQSGFWTLRLCKKKGYVALTSPPTSLHLHEQPLLVGIFLDYEAGVVSFYNGNTGCHIFTFPKASFSDTLRPYFQVYQYSPLFLPPPGD
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein and E3 SUMO-protein ligase that acts as a regulator of innate immunity (PubMed:23056470). Acts as a negative regulator of type I interferon IFN-beta production by catalyzing 'Lys-48'-linked polyubiquitination of AZI2/NAP1, leading to its degradation (By similarity). Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling (PubMed:23056470). Acts as positive regulator of the cGAS-STING pathway by acting as a E3 SUMO-protein ligase: mediates sumoylation of CGAS and STING, preventing their degradation and thereby activating the innate immune response to DNA virus (By similarity). Also acts as a negative regulator of NF-kappa-B signaling independently of its E3 protein ligase activity by promoting lysosome-dependent degradation of TAB2 and TAB3 adapters (PubMed:24434549). {ECO:0000250|UniProtKB:Q5SZ99, ECO:0000269|PubMed:23056470, ECO:0000269|PubMed:24434549}.
uniprot
proteins
mass_dalton
53416
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:23056470}.; PATHWAY: Protein modification; protein sumoylation. {ECO:0000250|UniProtKB:Q5SZ99}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23056470
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24434549
uniprot
proteins
pubmed
9149941
uniprot
proteins
sequence_length
465
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5SZ99}.
uniprot
proteins