Mxra8
entrez
74761
canonical
uniprot
Q9DBV4
canonical
ensembl
ENSMUSG00000029070
resolver
ensp
ENSMUSP00000030947
resolver
ensp
ENSMUSP00000256621
resolver
enst
ENSMUST00000030947
resolver
genesymbol
Mxra8
resolver
genesymbol_syn
Asp3
resolver
genesymbol_syn
Dicam
resolver
uniprot
Q76M97
resolver
uniprot
Q920S7
resolver
uniprot_entry
MXRA8_MOUSE
resolver
uniprot_sec
Q76M97
resolver
uniprot_sec
Q920S7
resolver
amino_acid_sequence
MELLSRVLLWKLLLLQSSAVLSSGPSGTAAASSSLVSESVVSLAAGTQAVLRCQSPRMVWTQDRLHDRQRVVHWDLSGGPGSQRRRLVDMYSAGEQRVYEPRDRDRLLLSPSAFHDGNFSLLIRAVDRGDEGVYTCNLHHHYCHLDESLAVRLEVTEDPLLSRAYWDGEKEVLVVAHGAPALMTCINRAHVWTDRHLEEAQQVVHWDRQLPGVSHDRADRLLDLYASGERRAYGPPFLRDRVSVNTNAFARGDFSLRIDELERADEGIYSCHLHHHYCGLHERRVFHLQVTEPAFEPPARASPGNGSGHSSAPSPDPTLTRGHSIINVIVPEDHTHFFQQLGYVLATLLLFILLLITVVLATRYRHSGGCKTSDKKAGKSKGKDVNMVEFAVATRDQAPYRTEDIQLDYKNNILKERAELAHSPLPAKDVDLDKEFRKEYCK
uniprot
proteins
function
FUNCTION: Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3 (PubMed:18366072, PubMed:22492581, PubMed:29702220). Mediates heterophilic cell-cell interactions in vitro (PubMed:18366072). Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (PubMed:22492581). Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (PubMed:29702220). Stimulates formation of primary cilia in chondrocytes (PubMed:29702220). Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway (PubMed:29702220). Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis (By similarity). Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells (By similarity). Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK (By similarity). May play a role in the maturation and maintenance of the blood-brain barrier (PubMed:14603461). {ECO:0000250|UniProtKB:Q9BRK3, ECO:0000269|PubMed:14603461, ECO:0000269|PubMed:18366072, ECO:0000269|PubMed:22492581, ECO:0000269|PubMed:29702220}.
uniprot
proteins
mass_dalton
49750
uniprot
proteins
mutagenesis
MUTAGEN 130; /note="D->E: No significant effect on integrin ITGAV:ITGB3 binding."; /evidence="ECO:0000269|PubMed:18366072"; MUTAGEN 253; /note="D->E: Reduced integrin ITGAV:ITGB3 binding."; /evidence="ECO:0000269|PubMed:18366072
uniprot
proteins
pubmed
14603461
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18366072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22492581
uniprot
proteins
pubmed
29702220
uniprot
proteins
sequence_length
442
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14603461, ECO:0000269|PubMed:18366072, ECO:0000269|PubMed:22492581}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, tight junction {ECO:0000269|PubMed:18366072}. Cytoplasm {ECO:0000269|PubMed:18366072, ECO:0000269|PubMed:29702220}. Cell projection, cilium membrane {ECO:0000269|PubMed:29702220}. Nucleus {ECO:0000269|PubMed:18366072}. Note=Primarily localizes to the cell membrane (PubMed:18366072). Detected in the cilium of primary chondrocytes (PubMed:29702220). Highly expressed at areas of cell-cell contact and may localize to tight junctions (PubMed:18366072). Also found in the nucleus where it is detected in the soluble (as opposed to chromatin-bound) fraction (PubMed:18366072). {ECO:0000269|PubMed:18366072, ECO:0000269|PubMed:29702220}.
uniprot
proteins
transmembrane_region
TRANSMEM 341..361; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins