SLC26A3
entrez
1811
canonical
uniprot
P40879
canonical
ensembl
ENSG00000091138
resolver
ensp
ENSP00000345873
resolver
ensp
ENSP00000522309
resolver
ensp
ENSP00000522310
resolver
ensp
ENSP00000522313
resolver
ensp
ENSP00000522316
resolver
ensp
ENSP00000522322
resolver
ensp
ENSP00000522329
resolver
enst
ENST00000340010
resolver
enst
ENST00000852250
resolver
enst
ENST00000852251
resolver
enst
ENST00000852254
resolver
enst
ENST00000852257
resolver
enst
ENST00000852263
resolver
enst
ENST00000852270
resolver
genesymbol
SLC26A3
resolver
genesymbol_syn
DRA
resolver
hgnc
HGNC:3018
resolver
uniprot_entry
S26A3_HUMAN
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by acidic pH. {ECO:0000269|PubMed:19321737}.
uniprot
proteins
amino_acid_sequence
MIEPFGNQYIVARPVYSTNAFEENHKKTGRHHKTFLDHLKVCCSCSPQKAKRIVLSLFPIASWLPAYRLKEWLLSDIVSGISTGIVAVLQGLAFALLVDIPPVYGLYASFFPAIIYLFFGTSRHISVGPFPILSMMVGLAVSGAVSKAVPDRNATTLGLPNNSNNSSLLDDERVRVAAAASVTVLSGIIQLAFGILRIGFVVIYLSESLISGFTTAAAVHVLVSQLKFIFQLTVPSHTDPVSIFKVLYSVFSQIEKTNIADLVTALIVLLVVSIVKEINQRFKDKLPVPIPIEFIMTVIAAGVSYGCDFKNRFKVAVVGDMNPGFQPPITPDVETFQNTVGDCFGIAMVAFAVAFSVASVYSLKYDYPLDGNQELIALGLGNIVCGVFRGFAGSTALSRSAVQESTGGKTQIAGLIGAIIVLIVVLAIGFLLAPLQKSVLAALALGNLKGMLMQFAEIGRLWRKDKYDCLIWIMTFIFTIVLGLGLGLAASVAFQLLTIVFRTQFPKCSTLANIGRTNIYKNKKDYYDMYEPEGVKIFRCPSPIYFANIGFFRRKLIDAVGFSPLRILRKRNKALRKIRKLQKQGLLQVTPKGFICTVDTIKDSDEELDNNQIEVLDQPINTTDLPFHIDWNDDLPLNIEVPKISLHSLILDFSAVSFLDVSSVRGLKSILQEFIRIKVDVYIVGTDDDFIEKLNRYEFFDGEVKSSIFFLTIHDAVLHILMKKDYSTSKFNPSQEKDGKIDFTINTNGGLRNRVYEVPVETKF
uniprot
proteins
disease_involvement
DISEASE: Diarrhea 1, secretory chloride, congenital (DIAR1) [MIM:214700]: A disease characterized by voluminous watery stools containing an excess of chloride. The children with this disease are often premature. {ECO:0000269|PubMed:11524734, ECO:0000269|PubMed:19861545, ECO:0000269|PubMed:21150650, ECO:0000269|PubMed:21394828, ECO:0000269|PubMed:22779076, ECO:0000269|PubMed:23274434, ECO:0000269|PubMed:28644346, ECO:0000269|PubMed:8896562, ECO:0000269|PubMed:9554749, ECO:0000269|PubMed:9718329}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Mediates chloride-bicarbonate exchange with a chloride bicarbonate stoichiometry of 2:1 in the intestinal epithelia (PubMed:16606687, PubMed:19321737, PubMed:22159084, PubMed:22627094). Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation (By similarity). {ECO:0000250|UniProtKB:Q9WVC8, ECO:0000269|PubMed:16606687, ECO:0000269|PubMed:19321737, ECO:0000269|PubMed:22159084, ECO:0000269|PubMed:22627094}.
uniprot
proteins
mass_dalton
84505
uniprot
proteins
mutagenesis
MUTAGEN 761..764; /note="Missing: Loss of interaction with NHERF4. No effect on localization to cell membrane or its exchanger activity."; /evidence="ECO:0000269|PubMed:22627094
uniprot
proteins
post_translational_modification
PTM: N-glycosylation is required for efficient cell surface expression, and protection from proteolytic degradation. {ECO:0000269|PubMed:22159084}.
uniprot
proteins
protein_family
SLC26A/SulP transporter (TC 2.A.53) family
uniprot
proteins
pubmed
11524734
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15766278
uniprot
proteins
pubmed
16606687
uniprot
proteins
pubmed
19321737
uniprot
proteins
pubmed
19861545
uniprot
proteins
pubmed
21150650
uniprot
proteins
pubmed
21394828
uniprot
proteins
pubmed
22159084
uniprot
proteins
pubmed
22627094
uniprot
proteins
pubmed
22779076
uniprot
proteins
pubmed
23274434
uniprot
proteins
pubmed
28644346
uniprot
proteins
pubmed
7683425
uniprot
proteins
pubmed
8140616
uniprot
proteins
pubmed
8896562
uniprot
proteins
pubmed
9554749
uniprot
proteins
pubmed
9718329
uniprot
proteins
sequence_length
764
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:22159084}; Multi-pass membrane protein {ECO:0000255}. Membrane {ECO:0000250|UniProtKB:Q9WVC8}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:19321737, ECO:0000269|PubMed:22627094}; Multi-pass membrane protein {ECO:0000255}. Note=Localized in sperm membranes. Midpiece of sperm tail. Colocalizes with CFTR at the midpiece of sperm tail (By similarity). {ECO:0000250|UniProtKB:Q9WVC8}.
uniprot
proteins
transmembrane_region
TRANSMEM 77..97; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 100..120; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 125..145; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 176..196; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 198..218; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 258..278; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 343..363; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 375..395; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 412..432; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 470..490; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins