Ckb
entrez
12709
canonical
uniprot
Q04447
canonical
ensembl
ENSMUSG00000001270
resolver
ensp
ENSMUSP00000001304
resolver
enst
ENSMUST00000001304
resolver
genesymbol
Ckb
resolver
genesymbol_syn
Ckbb
resolver
uniprot
Q3KQP4
resolver
uniprot
Q3TKI3
resolver
uniprot
Q3U5P5
resolver
uniprot
Q3UF71
resolver
uniprot
Q9CXK6
resolver
uniprot_entry
KCRB_MOUSE
resolver
uniprot_sec
Q3KQP4
resolver
uniprot_sec
Q3TKI3
resolver
uniprot_sec
Q3U5P5
resolver
uniprot_sec
Q3UF71
resolver
uniprot_sec
Q9CXK6
resolver
amino_acid_sequence
MPFSNSHNTQKLRFPAEDEFPDLSSHNNHMAKVLTPELYAELRAKCTPSGFTLDDAIQTGVDNPGHPYIMTVGAVAGDEESYDVFKDLFDPIIEERHGGYQPSDEHKTDLNPDNLQGGDDLDPNYVLSSRVRTGRSIRGFCLPPHCSRGERRAIEKLAVEALSSLDGDLSGRYYALKSMTEAEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKTFLVWINEEDHLRVISMQKGGNMKEVFTRFCTGLTQIETLFKSKNYEFMWNPHLGYILTCPSNLGTGLRAGVHIKLPHLGKHEKFSEVLKRLRLQKRGTGGVDTAAVGGVFDVSNADRLGFSEVELVQMVVDGVKLLIEMEQRLEQGQAIDDLMPAQK
uniprot
proteins
ec_number
2.7.3.2
uniprot
proteins
function
FUNCTION: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:33597756). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (PubMed:33597756). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (PubMed:33597756). {ECO:0000269|PubMed:33597756, ECO:0000305}.
uniprot
proteins
mass_dalton
42713
uniprot
proteins
mutagenesis
MUTAGEN 130..138; /note="RVRTGRSIR->AVATGASIA: Abolishes localization to mitochondria in fat cells."; /evidence="ECO:0000269|PubMed:33597756"; MUTAGEN 283; /note="C->S: Abolished creatine kinase activity."; /evidence="ECO:0000269|PubMed:33597756
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the ECS(ASB9) complex, leading to its degradation by the proteasome. {ECO:0000250|UniProtKB:P12277}.
uniprot
proteins
protein_family
ATP:guanido phosphotransferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15648052
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
16800626
uniprot
proteins
pubmed
17148442
uniprot
proteins
pubmed
1740343
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
18566107
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
33597756
uniprot
proteins
pubmed
3641191
uniprot
proteins
sequence_length
381
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305|PubMed:33597756}. Mitochondrion {ECO:0000269|PubMed:33597756}. Cell membrane {ECO:0000250|UniProtKB:P12277}. Note=Localizes to the mitochondria of thermogenic fat cells via the internal MTS-like signal (iMTS-L) region. {ECO:0000269|PubMed:33597756}.
uniprot
proteins