TUBG2
entrez
27175
canonical
uniprot
Q9NRH3
canonical
ensembl
ENSG00000037042
resolver
ensp
ENSP00000251412
resolver
ensp
ENSP00000524943
resolver
enst
ENST00000251412
resolver
genesymbol
TUBG2
resolver
hgnc
HGNC:12419
resolver
uniprot
A0A1B4Z394
resolver
uniprot
A6NDI4
resolver
uniprot
Q32NB2
resolver
uniprot_entry
A0A1B4Z394_HUMAN
resolver
uniprot_entry
TBG2_HUMAN
resolver
uniprot_sec
A6NDI4
resolver
uniprot_sec
Q32NB2
resolver
amino_acid_sequence
MPREIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFATEGTDRKDVFFYQADDEHYIPRAVLLDLEPRVIHSILNSPYAKLYNPENIYLSEHGGGAGNNWASGFSQGEKIHEDIFDIIDREADGSDSLEGFVLCHSIAGGTGSGLGSYLLERLNDRYPKKLVQTYSVFPYQDEMSDVVVQPYNSLLTLKRLTQNADCVVVLDNTALNRIATDRLHIQNPSFSQINQLVSTIMSASTTTLRYPGYMNNDLIGLIASLIPTPRLHFLMTGYTPLTTDQSVASVRKTTVLDVMRRLLQPKNVMVSTGRDRQTNHCYIAILNIIQGEVDPTQVHKSLQRIRERKLANFIPWGPASIQVALSRKSPYLPSAHRVSGLMMANHTSISSLFESSCQQFDKLRKRDAFLEQFRKEDMFKDNFDEMDRSREVVQELIDEYHAATQPDYISWGTQEQ
uniprot
proteins
function
FUNCTION: Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (PubMed:38305685). Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (PubMed:38305685). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38305685). {ECO:0000269|PubMed:38305685}.
uniprot
proteins
mass_dalton
51092
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome.
uniprot
proteins
protein_family
Tubulin family
uniprot
proteins
pubmed
10903841
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
38305685
uniprot
proteins
sequence_length
451
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000305}.
uniprot
proteins