TTC1
entrez
7265
canonical
uniprot
Q99614
canonical
ensembl
ENSG00000113312
resolver
ensp
ENSP00000231238
resolver
ensp
ENSP00000429225
resolver
ensp
ENSP00000507891
resolver
ensp
ENSP00000564286
resolver
ensp
ENSP00000564287
resolver
ensp
ENSP00000564288
resolver
ensp
ENSP00000582970
resolver
ensp
ENSP00000633883
resolver
enst
ENST00000231238
resolver
enst
ENST00000522793
resolver
enst
ENST00000682719
resolver
enst
ENST00000894227
resolver
enst
ENST00000894228
resolver
enst
ENST00000894229
resolver
enst
ENST00000912911
resolver
enst
ENST00000963824
resolver
genesymbol
TTC1
resolver
genesymbol_syn
TPR1
resolver
hgnc
HGNC:12391
resolver
uniprot
B2RCT2
resolver
uniprot
D3DQJ8
resolver
uniprot
Q9BVT3
resolver
uniprot_entry
TTC1_HUMAN
resolver
uniprot_sec
B2RCT2
resolver
uniprot_sec
D3DQJ8
resolver
uniprot_sec
Q9BVT3
resolver
amino_acid_sequence
MGEKSENCGVPEDLLNGLKVTDTQEAECAGPPVPDPKNQHSQSKLLRDDEAHLQEDQGEEECFHDCSASFEEEPGADKVENKSNEDVNSSELDEEYLIELEKNMSDEEKQKRREESTRLKEEGNEQFKKGDYIEAESSYSRALEMCPSCFQKERSILFSNRAAARMKQDKKEMAINDCSKAIQLNPSYIRAILRRAELYEKTDKLDEALEDYKSILEKDPSIHQAREACMRLPKQIEERNERLKEEMLGKLKDLGNLVLRPFGLSTENFQIKQDSSTGSYSINFVQNPNNNR
uniprot
proteins
function
FUNCTION: Adapter protein that plays a role downstream of GNA15 to stimulate Ras activation and subsequent phosphorylation of ERK1/2 independently of phospholipase Cbeta signaling (PubMed:12748287, PubMed:21486497). Mechanistically, interacts with GNA15 and SOS2 to form a macromolecular signaling complex which has a high affinity for HRAS (PubMed:20639119). Additionally, participates in signaling via other G-alpha proteins like GNA14, activating NF-kappa-B through Ras and ERK pathways (PubMed:22711498). Beyond signaling, supports protein homeostasis by cooperating with HSP40 in the HSP70 chaperone cycle, promoting protein folding through the regulated dissociation of the HSP70 inhibitor HSPBP1 (PubMed:14503850). {ECO:0000269|PubMed:12748287, ECO:0000269|PubMed:14503850, ECO:0000269|PubMed:20639119, ECO:0000269|PubMed:21486497, ECO:0000269|PubMed:22711498}.
uniprot
proteins
mass_dalton
33526
uniprot
proteins
pubmed
12748287
uniprot
proteins
pubmed
14503850
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15708368
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20639119
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21486497
uniprot
proteins
pubmed
22711498
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29120066
uniprot
proteins
pubmed
8836031
uniprot
proteins
sequence_length
292
uniprot
proteins