Slc2a5
entrez
65197
canonical
uniprot
P43427
canonical
ensembl
ENSRNOG00000017693
resolver
ensembl
ENSRNOG00055015167
resolver
ensembl
ENSRNOG00060024156
resolver
ensembl
ENSRNOG00065011308
resolver
ensp
ENSRNOP00000024054
resolver
ensp
ENSRNOP00055021265
resolver
ensp
ENSRNOP00060035248
resolver
ensp
ENSRNOP00065014090
resolver
enst
ENSRNOT00000024054
resolver
enst
ENSRNOT00055026133
resolver
enst
ENSRNOT00060042553
resolver
enst
ENSRNOT00065018425
resolver
genesymbol
Slc2a5
resolver
genesymbol_syn
Glut5
resolver
uniprot
B1WBQ4
resolver
uniprot_entry
B1WBQ4_RAT
resolver
uniprot_entry
GTR5_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Fructose uptake is inhibited by mercury ions (PubMed:26416735). Fructose uptake is only slightly inhibited by cytochalasin B (PubMed:8333543, PubMed:9820812). {ECO:0000269|PubMed:26416735, ECO:0000269|PubMed:8333543, ECO:0000269|PubMed:9820812}.
uniprot
proteins
amino_acid_sequence
MEKEDQEKTGKLTLVLALATFLAAFGSSFQYGYNVAAVNSPSEFMQQFYNDTYYDRNKENIESFTLTLLWSLTVSMFPFGGFIGSLMVGFLVNNLGRKGALLFNNIFSILPAILMGCSKIAKSFEIIIASRLLVGICAGISSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQLFGLRSVLASEEGWPILLGLTGVPAGLQLLLLPFFPESPRYLLIQKKNESAAEKALQTLRGWKDVDMEMEEIRKEDEAEKAAGFISVWKLFRMQSLRWQLISTIVLMAGQQLSGVNAIYYYADQIYLSAGVKSNDVQYVTAGTGAVNVFMTMVTVFVVELWGRRNLLLIGFSTCLTACIVLTVALALQNTISWMPYVSIVCVIVYVIGHAVGPSPIPALFITEIFLQSSRPSAYMIGGSVHWLSNFIVGLIFPFIQVGLGPYSFIIFAIICLLTTIYIFMVVPETKGRTFVEINQIFAKKNKVSDVYPEKEEKELNDLPPATREQ
uniprot
proteins
function
FUNCTION: Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:26416735, PubMed:8333543, PubMed:9820812). Can mediate the uptake of deoxyglucose, but with low efficiency (PubMed:8333543). Essential for fructose uptake in the small intestine (By similarity). Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose (By similarity). Required for the development of high blood pressure in response to high dietary fructose intake (By similarity). {ECO:0000250|UniProtKB:Q9WV38, ECO:0000269|PubMed:26416735, ECO:0000269|PubMed:8333543, ECO:0000269|PubMed:9820812}.
uniprot
proteins
mass_dalton
55543
uniprot
proteins
mutagenesis
MUTAGEN 166; /note="Q->E: Impairs D-fructose binding."; /evidence="ECO:0000269|PubMed:26416735
uniprot
proteins
protein_family
Glucose transporter subfamily
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Sugar transporter (TC 2.A.1.1) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
26416735
uniprot
proteins
pubmed
8333543
uniprot
proteins
pubmed
8404647
uniprot
proteins
pubmed
9820812
uniprot
proteins
sequence_length
502
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q9WV38}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9WV38}. Cell membrane {ECO:0000269|PubMed:26416735, ECO:0000269|PubMed:8333543, ECO:0000269|PubMed:9820812}; Multi-pass membrane protein {ECO:0000269|PubMed:26416735}. Cell membrane, sarcolemma {ECO:0000269|PubMed:9820812}. Note=Localized on the apical membrane of jejunum villi, but also on lateral plasma membranes of the villi. Transport to the cell membrane is dependent on RAB11A. {ECO:0000250|UniProtKB:Q9WV38}.
uniprot
proteins
transmembrane_region
TRANSMEM 18..38; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:26416735"; TRANSMEM 68..90; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:26416735"; TRANSMEM 98..118; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:26416735"; TRANSMEM 126..148; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:26416735"; TRANSMEM 161..181; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:26416735"; TRANSMEM 192..212; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:26416735"; TRANSMEM 277..297; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:26416735"; TRANSMEM 313..333; /note="Helical; Name=8"; /evidence="ECO:0000269|PubMed:26416735"; TRANSMEM 342..362; /note="Helical; Name=9"; /evidence="ECO:0000269|PubMed:26416735"; TRANSMEM 371..393; /note="Helical; Name=10"; /evidence="ECO:0000269|PubMed:26416735"; TRANSMEM 412..432; /note="Helical; Name=11"; /evidence="ECO:0000269|PubMed:26416735"; TRANSMEM 439..459; /note="Helical; Name=12"; /evidence="ECO:0000269|PubMed:26416735
uniprot
proteins