Dcstamp
entrez
75766
canonical
uniprot
Q7TNJ0
canonical
ensembl
ENSMUSG00000022303
resolver
ensp
ENSMUSP00000022913
resolver
ensp
ENSMUSP00000153957
resolver
ensp
ENSMUSP00000154362
resolver
ensp
ENSMUSP00000154397
resolver
ensp
ENSMUSP00000285765
resolver
enst
ENSMUST00000227792
resolver
genesymbol
Dcstamp
resolver
genesymbol_syn
Tm7sf4
resolver
uniprot
A0A2I3BPX1
resolver
uniprot
B2RT61
resolver
uniprot
Q6R315
resolver
uniprot
Q7TNI9
resolver
uniprot
Q9D619
resolver
uniprot_entry
A0A2I3BPX1_MOUSE
resolver
uniprot_entry
DCSTP_MOUSE
resolver
uniprot_sec
B2RT61
resolver
uniprot_sec
Q6R315
resolver
uniprot_sec
Q7TNI9
resolver
uniprot_sec
Q9D619
resolver
amino_acid_sequence
MRLWTLGTSIFLRLWGTYVFPRSPSWLDFIQHLGVCCFVAFLSVSLFSAAFYWILPPVALLSSVWMITCVFLCCSKRARCFILLAVLSCGLREGRNALIAAGTGVVIFGHVENIFYNFRGLLDSMTCNLRAKSFSVHFPLLKRYTEAIQWIYGLATPLNLFDDLVSWNQTLVVSLFSPSHALEAHMNDTRGEVLGVLHHMVVTTELLTSVGQKLLALAGLLLILVSTGLFLKRFLGPCGWKYENVYITKQFVRFDEKERHQQRPCVLPLNKKERKKYVIVPSLQLTPKEKKTLGLFFLPVLTYLYMWVLFAAVDYLLYRLISSMNKQFQSLPGLEVHLKLRGEKQGTQGVVHDSAFNISMFEPSCIPKPRLSVSETWVPLSIILLTLIILGLLSSMLMQLKILVSVSFYPKVERERIEYLHAKLLEKRSKQPLREADGKPSLYFKKIHFWFPVLKMIRKKQTIPANEDDL
uniprot
proteins
function
FUNCTION: Probable cell surface receptor that plays several roles in cellular fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic granulocytes. Plays also a role in the regulation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions. {ECO:0000269|PubMed:15452179, ECO:0000269|PubMed:16061724, ECO:0000269|PubMed:16937266, ECO:0000269|PubMed:17164993, ECO:0000269|PubMed:17713547, ECO:0000269|PubMed:18653699, ECO:0000269|PubMed:18952287, ECO:0000269|PubMed:20039274, ECO:0000269|PubMed:22337159}.
uniprot
proteins
mass_dalton
53876
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:15601667}.
uniprot
proteins
pubmed
15452179
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15601667
uniprot
proteins
pubmed
16061724
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16937266
uniprot
proteins
pubmed
17164993
uniprot
proteins
pubmed
17713547
uniprot
proteins
pubmed
18653699
uniprot
proteins
pubmed
18952287
uniprot
proteins
pubmed
20039274
uniprot
proteins
pubmed
22337159
uniprot
proteins
sequence_length
470
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Endosome. Note=Localized to the cell surface in osteoclasts and undifferentiated monocytes. Intracellular internalized DCSTAMP is detected in a fraction of RANKL-induced osteoclast precursor. Colocalizes with OS9 in the endoplasmic reticulum (ER) of immature dendritic cell (DC). Translocates from the endoplasmic reticulum to the intermediate/Golgi compartment upon maturation of DC in a OS9-dependent manner. Colocalizes with LAMP1 in endosomes.
uniprot
proteins
transmembrane_region
TRANSMEM 34..54; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 56..76; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 98..118; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 210..230; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 293..313; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 377..397; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins