CHLSN
entrez
84310
canonical
uniprot
Q9BRJ6
canonical
ensembl
ENSG00000146540
resolver
ensp
ENSP00000350011
resolver
ensp
ENSP00000380286
resolver
ensp
ENSP00000380288
resolver
ensp
ENSP00000523189
resolver
ensp
ENSP00000523190
resolver
ensp
ENSP00000779629
resolver
enst
ENST00000357429
resolver
enst
ENST00000397098
resolver
enst
ENST00000397100
resolver
enst
ENST00000853130
resolver
enst
ENST00000853131
resolver
genesymbol
CHLSN
resolver
genesymbol_syn
C7orf50
resolver
hgnc
HGNC:22421
resolver
uniprot_entry
CHOLN_HUMAN
resolver
amino_acid_sequence
MAKQKRKVPEVTEKKNKKLKKASAEGPLLGPEAAPSGEGAGSKGEAVLRPGLDAEPELSPEEQRVLERKLKKERKKEERQRLREAGLVAQHPPARRSGAELALDYLCRWAQKHKNWRFQKTRQTWLLLHMYDSDKVPDEHFSTLLAYLEGLQGRARELTVQKAEALMRELDEEGSDPPLPGRAQRIRQVLQLLS
uniprot
proteins
function
FUNCTION: Hormone secreted from the intestine in response to cholesterol, where it acts to inhibit cholesterol synthesis in the liver and VLDL secretion,leading to a reduction in circulating cholesterol levels. Acts through binding to its receptor, GPR146. {ECO:0000269|PubMed:38503280}.
uniprot
proteins
mass_dalton
22083
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
38503280
uniprot
proteins
sequence_length
194
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:38503280}. Note=Secreted via exosomes, secretion is induced by feeding and cholesterol absorption. {ECO:0000269|PubMed:38503280}.
uniprot
proteins