SPRY1
entrez
10252
canonical
uniprot
O43609
canonical
ensembl
ENSG00000164056
resolver
ensp
ENSP00000343785
resolver
ensp
ENSP00000377871
resolver
ensp
ENSP00000480540
resolver
ensp
ENSP00000481675
resolver
ensp
ENSP00000498292
resolver
ensp
ENSP00000529036
resolver
ensp
ENSP00000529037
resolver
ensp
ENSP00000529038
resolver
ensp
ENSP00000597784
resolver
ensp
ENSP00000597785
resolver
ensp
ENSP00000597786
resolver
ensp
ENSP00000597787
resolver
ensp
ENSP00000597788
resolver
ensp
ENSP00000612616
resolver
enst
ENST00000339241
resolver
enst
ENST00000394339
resolver
enst
ENST00000610581
resolver
enst
ENST00000622283
resolver
enst
ENST00000651917
resolver
enst
ENST00000858977
resolver
enst
ENST00000858978
resolver
enst
ENST00000858979
resolver
enst
ENST00000927725
resolver
enst
ENST00000927726
resolver
enst
ENST00000927727
resolver
enst
ENST00000927728
resolver
enst
ENST00000927729
resolver
enst
ENST00000942557
resolver
genesymbol
SPRY1
resolver
hgnc
HGNC:11269
resolver
uniprot
D3DNX6
resolver
uniprot
Q6PNE0
resolver
uniprot_entry
SPY1_HUMAN
resolver
uniprot_sec
D3DNX6
resolver
uniprot_sec
Q6PNE0
resolver
amino_acid_sequence
MDPQNQHGSGSSLVVIQQPSLDSRQRLDYEREIQPTAILSLDQIKAIRGSNEYTEGPSVVKRPAPRTAPRQEKHERTHEIIPINVNNNYEHRHTSHLGHAVLPSNARGPILSRSTSTGSAASSGSNSSASSEQGLLGRSPPTRPVPGHRSERAIRTQPKQLIVDDLKGSLKEDLTQHKFICEQCGKCKCGECTAPRTLPSCLACNRQCLCSAESMVEYGTCMCLVKGIFYHCSNDDEGDSYSDNPCSCSQSHCCSRYLCMGAMSLFLPCLLCYPPAKGCLKLCRRCYDWIHRPGCRCKNSNTVYCKLESCPSRGQGKPS
uniprot
proteins
function
FUNCTION: Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q9QXV9}.
uniprot
proteins
mass_dalton
35122
uniprot
proteins
protein_family
Sprouty family
uniprot
proteins
pubmed
14533010
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
9458049
uniprot
proteins
sequence_length
319
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Note=Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor).
uniprot
proteins