GHITM
entrez
27069
canonical
uniprot
Q9H3K2
canonical
ensembl
ENSG00000165678
resolver
ensp
ENSP00000361207
resolver
ensp
ENSP00000508495
resolver
ensp
ENSP00000508559
resolver
ensp
ENSP00000509112
resolver
ensp
ENSP00000509674
resolver
ensp
ENSP00000509697
resolver
ensp
ENSP00000509708
resolver
ensp
ENSP00000510216
resolver
ensp
ENSP00000510236
resolver
ensp
ENSP00000510576
resolver
ensp
ENSP00000567480
resolver
ensp
ENSP00000567483
resolver
ensp
ENSP00000567484
resolver
ensp
ENSP00000567485
resolver
ensp
ENSP00000567486
resolver
ensp
ENSP00000567487
resolver
ensp
ENSP00000594150
resolver
ensp
ENSP00000594151
resolver
ensp
ENSP00000594152
resolver
ensp
ENSP00000594154
resolver
ensp
ENSP00000615401
resolver
ensp
ENSP00000615403
resolver
ensp
ENSP00000615404
resolver
ensp
ENSP00000615405
resolver
ensp
ENSP00000615406
resolver
enst
ENST00000372134
resolver
enst
ENST00000686247
resolver
enst
ENST00000686583
resolver
enst
ENST00000687085
resolver
enst
ENST00000688802
resolver
enst
ENST00000690067
resolver
enst
ENST00000690283
resolver
enst
ENST00000690920
resolver
enst
ENST00000691155
resolver
enst
ENST00000691609
resolver
enst
ENST00000897421
resolver
enst
ENST00000897424
resolver
enst
ENST00000897425
resolver
enst
ENST00000897426
resolver
enst
ENST00000897427
resolver
enst
ENST00000897428
resolver
enst
ENST00000924091
resolver
enst
ENST00000924092
resolver
enst
ENST00000924093
resolver
enst
ENST00000924095
resolver
enst
ENST00000945342
resolver
enst
ENST00000945344
resolver
enst
ENST00000945345
resolver
enst
ENST00000945346
resolver
enst
ENST00000945347
resolver
genesymbol
GHITM
resolver
genesymbol_syn
DERP2
resolver
genesymbol_syn
MICS1
resolver
genesymbol_syn
TMBIM5
resolver
hgnc
HGNC:17281
resolver
uniprot
A8K9Z9
resolver
uniprot
D3DWE0
resolver
uniprot
O95894
resolver
uniprot
Q5VT95
resolver
uniprot
Q9H0P2
resolver
uniprot_entry
GHITM_HUMAN
resolver
uniprot_sec
A8K9Z9
resolver
uniprot_sec
D3DWE0
resolver
uniprot_sec
O95894
resolver
uniprot_sec
Q5VT95
resolver
uniprot_sec
Q9H0P2
resolver
amino_acid_sequence
MLAARLVCLRTLPSRVFHPAFTKASPVVKNSITKNQWLLTPSREYATKTRIGIRRGRTGQELKEAALEPSMEKIFKIDQMGRWFVAGGAAVGLGALCYYGLGLSNEIGAIEKAVIWPQYVKDRIHSTYMYLAGSIGLTALSAIAISRTPVLMNFMMRGSWVTIGVTFAAMVGAGMLVRSIPYDQSPGPKHLAWLLHSGVMGAVVAPLTILGGPLLIRAAWYTAGIVGGLSTVAMCAPSEKFLNMGAPLGVGLGLVFVSSLGSMFLPPTTVAGATLYSVAMYGGLVLFSMFLLYDTQKVIKRAEVSPMYGVQKYDPINSMLSIYMDTLNIFMRVATMLATGGNRKK
uniprot
proteins
function
FUNCTION: Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport (PubMed:18417609, PubMed:32977469, PubMed:35912435, PubMed:36321428). Mediates proton-dependent calcium efflux from mitochondrion (PubMed:35912435, PubMed:36321428). Also functions as an electroneutral mitochondrial proton/potassium exchanger (PubMed:36321428). Required for the mitochondrial tubular network and cristae organization (PubMed:18417609, PubMed:32977469, PubMed:36321428). Involved in apoptotic release of cytochrome c (PubMed:18417609). Inhibits the proteolytic activity of AFG3L2, stimulating respiration and stabilizing respiratory enzymes in actively respiring mitochondria (PubMed:36321428). However, when mitochondria become hyperpolarized, GHITM loses its inhibitory activity toward AFG3L2 and the now the active AFG3L2 turns first on GHITM and, if hyperpolarization persists, on other proteins of the mitochondria, leading to a broad remodeling of the mitochondrial proteome (PubMed:36321428). {ECO:0000269|PubMed:18417609, ECO:0000269|PubMed:35912435, ECO:0000269|PubMed:36321428}.
uniprot
proteins
mass_dalton
37205
uniprot
proteins
post_translational_modification
PTM: Undergoes AFG3L2-mediated proteolytic degradation, upon hyperpolarization of mitochondria. {ECO:0000269|PubMed:35912435}.
uniprot
proteins
protein_family
BI1 family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18417609
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
32977469
uniprot
proteins
pubmed
35912435
uniprot
proteins
pubmed
36321428
uniprot
proteins
sequence_length
345
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:18417609}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 83..103; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 126..146; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 160..180; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 191..211; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 214..234; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 245..265; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 272..292; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins