GNA15
entrez
2769
canonical
uniprot
P30679
canonical
ensembl
ENSG00000060558
resolver
ensp
ENSP00000262958
resolver
enst
ENST00000262958
resolver
genesymbol
GNA15
resolver
genesymbol_syn
GNA16
resolver
hgnc
HGNC:4383
resolver
uniprot
E9KL40
resolver
uniprot
E9KL47
resolver
uniprot
O75247
resolver
uniprot
Q53XK2
resolver
uniprot_entry
GNA15_HUMAN
resolver
uniprot_sec
E9KL40
resolver
uniprot_sec
E9KL47
resolver
uniprot_sec
O75247
resolver
uniprot_sec
Q53XK2
resolver
amino_acid_sequence
MARSLTWRCCPWCLTEDEKAAARVDQEINRILLEQKKQDRGELKLLLLGPGESGKSTFIKQMRIIHGAGYSEEERKGFRPLVYQNIFVSMRAMIEAMERLQIPFSRPESKHHASLVMSQDPYKVTTFEKRYAAAMQWLWRDAGIRACYERRREFHLLDSAVYYLSHLERITEEGYVPTAQDVLRSRMPTTGINEYCFSVQKTNLRIVDVGGQKSERKKWIHCFENVIALIYLASLSEYDQCLEENNQENRMKESLALFGTILELPWFKSTSVILFLNKTDILEEKIPTSHLATYFPSFQGPKQDAEAAKRFILDMYTRMYTGCVDGPEGSKKGARSRRLFSHYTCATDTQNIRKVFKDVRDSVLARYLDEINLL
uniprot
proteins
function
FUNCTION: Member of the G protein alpha subunit family that plays a crucial role in intracellular signaling. Functions as a molecular switch, transducing signals from G protein-coupled receptors (GPCRs) to downstream effectors. In collaboration with the adapter protein TTC1, promotes HRAS activation and ERK1/2 phosphorylation independently of phospholipase Cbeta signaling (PubMed:12748287, PubMed:20639119). Also initiates EMR2-mediated signaling, leading to activation of Akt, MAPK, and NF-kappa-B, which in turn drives macrophage differentiation and inflammatory responses (PubMed:28421075). {ECO:0000269|PubMed:12748287, ECO:0000269|PubMed:20639119, ECO:0000269|PubMed:28421075}.
uniprot
proteins
mass_dalton
43508
uniprot
proteins
mutagenesis
MUTAGEN 212; /note="Q->L: GTPase-deficient mutant. No loss of binding to TTC1."; /evidence="ECO:0000269|PubMed:12748287
uniprot
proteins
protein_family
G(q) subfamily
uniprot
proteins
protein_family
G-alpha family
uniprot
proteins
pubmed
12748287
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1905813
uniprot
proteins
pubmed
20639119
uniprot
proteins
pubmed
20736409
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28421075
uniprot
proteins
sequence_length
374
uniprot
proteins