Tbl1xr1
entrez
81004
canonical
uniprot
Q8BHJ5
canonical
ensembl
ENSMUSG00000027630
resolver
ensp
ENSMUSP00000067164
resolver
ensp
ENSMUSP00000141363
resolver
ensp
ENSMUSP00000142184
resolver
ensp
ENSMUSP00000144436
resolver
ensp
ENSMUSP00000279624
resolver
ensp
ENSMUSP00000279626
resolver
ensp
ENSMUSP00000279627
resolver
ensp
ENSMUSP00000279632
resolver
enst
ENSMUST00000063988
resolver
enst
ENSMUST00000192328
resolver
enst
ENSMUST00000193734
resolver
enst
ENSMUST00000202747
resolver
genesymbol
Tbl1xr1
resolver
genesymbol_syn
Ira1
resolver
genesymbol_syn
Tblr1
resolver
uniprot
Q3UWL6
resolver
uniprot
Q8CBG4
resolver
uniprot
Q8VEG3
resolver
uniprot
Q9EQD4
resolver
uniprot_entry
TBL1R_MOUSE
resolver
uniprot_sec
Q3UWL6
resolver
uniprot_sec
Q8CBG4
resolver
uniprot_sec
Q8VEG3
resolver
uniprot_sec
Q9EQD4
resolver
amino_acid_sequence
MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALVPPAALISIIQKGLQYVEAEVSINEDGTLFDGRPIESLSLIDAVMPDVVQTRQQAYRDKLAQQHAAAAAAAAAATNQQGSAKNGENTANGEENGAHTIANNHTDMMEVDGDVEIPSNKAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGPTQLVLRHCIREGGQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCKLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVCVLDLRK
uniprot
proteins
function
FUNCTION: F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
55661
uniprot
proteins
mutagenesis
MUTAGEN 171; /note="E->A: Significantly decreases interaction with MECP2."; /evidence="ECO:0000269|PubMed:28348241"; MUTAGEN 171; /note="E->Q: Significantly decreases interaction with MECP2."; /evidence="ECO:0000269|PubMed:28348241"; MUTAGEN 214; /note="C->S: Does not affect interaction with MECP2."; /evidence="ECO:0000269|PubMed:28348241"; MUTAGEN 313; /note="D->N: Abolishes interaction with MECP2."; /evidence="ECO:0000269|PubMed:28348241"; MUTAGEN 351; /note="E->A: Weakly decreases interaction with MECP2."; /evidence="ECO:0000269|PubMed:28348241"; MUTAGEN 351; /note="E->D: Does not affect interaction with MECP2."; /evidence="ECO:0000269|PubMed:28348241"; MUTAGEN 369; /note="D->A: Abolishes interaction with MECP2."; /evidence="ECO:0000269|PubMed:28348241"; MUTAGEN 369; /note="D->E: Substantially reduces interaction with MECP2."; /evidence="ECO:0000269|PubMed:28348241"; MUTAGEN 444; /note="P->R: Mildly affects interaction with MECP2."; /evidence="ECO:0000269|PubMed:28348241"; MUTAGEN 446; /note="Y->F: Does not affect interaction with MECP2."; /evidence="ECO:0000269|PubMed:28348241
uniprot
proteins
protein_family
WD repeat EBI family
uniprot
proteins
pubmed
11063877
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
28348241
uniprot
proteins
sequence_length
514
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins