Il31
entrez
76399
canonical
uniprot
Q6EAL8
canonical
ensembl
ENSMUSG00000029437
resolver
ensp
ENSMUSP00000031389
resolver
ensp
ENSMUSP00000143125
resolver
enst
ENSMUST00000031389
resolver
enst
ENSMUST00000198901
resolver
genesymbol
Il31
resolver
uniprot
A0A0G2JFD1
resolver
uniprot
Q9DAD2
resolver
uniprot_entry
A0A0G2JFD1_MOUSE
resolver
uniprot_entry
IL31_MOUSE
resolver
uniprot_entry
Q9DAD2_MOUSE
resolver
amino_acid_sequence
MIFHTGTTKPTLVLLCCIGTWLATCSLSFGAPISKEDLRTTIDLLKQESQDLYNNYSIKQASGMSADESIQLPCFSLDREALTNISVIIAHLEKVKVLSENTVDTSWVIRWLTNISCFNPLNLNISVPGNTDESYDCKVFVLTVLKQFSNCMAELQAKDNTTC
uniprot
proteins
function
FUNCTION: Functions as a cytokine that binds to IL31RA, a membrane-bound signal-transducing subunit of the IL31 receptor complex (heterodimer composed of OSMR and IL31RA) (By similarity). Functionally, IL31 signaling via OSMR/IL31RA is particularly important in skin immunity (PubMed:15184896). Mechanistically, ligand binding to IL31RA, induces heterodimerization with OSMR, activating JAK1 and JAK2 (and to a lesser extent TYK2) associated with the intracellular domains of IL31RA and OSMR. These kinases phosphorylate tyrosine residues on IL31RA and OSMR, creating docking sites for STAT1, STAT3, and STAT5B, which are then phosphorylated and activated. In addition, the IL31 receptor complex activates the MAPK pathway (MAPK3/ERK1-MAPK1/ERK2) via recruitment of the adapter protein SHC1 (By similarity). Enhances myeloid progenitor cell survival in vitro (PubMed:17379091). Induces RETNLA and serum amyloid A protein expression in macrophages (PubMed:25847241). {ECO:0000250|UniProtKB:Q6EBC2, ECO:0000269|PubMed:15184896, ECO:0000269|PubMed:17379091, ECO:0000269|PubMed:25847241}.
uniprot
proteins
mass_dalton
18120
uniprot
proteins
pubmed
15184896
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17379091
uniprot
proteins
pubmed
25847241
uniprot
proteins
sequence_length
163
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q6EBC2}.
uniprot
proteins