EIF2D
entrez
1939
canonical
uniprot
P41214
canonical
ensembl
ENSG00000143486
resolver
ensp
ENSP00000271764
resolver
ensp
ENSP00000356081
resolver
ensp
ENSP00000581050
resolver
ensp
ENSP00000581052
resolver
ensp
ENSP00000782859
resolver
genesymbol
EIF2D
resolver
genesymbol_syn
HCA56
resolver
genesymbol_syn
LGTN
resolver
hgnc
HGNC:6583
resolver
uniprot
Q5SY40
resolver
uniprot
Q8IXV3
resolver
uniprot
Q96DG3
resolver
uniprot
Q96TG7
resolver
uniprot
Q9NR27
resolver
uniprot
Q9NSN0
resolver
uniprot
Q9NV18
resolver
uniprot
Q9NZ21
resolver
uniprot_entry
EIF2D_HUMAN
resolver
uniprot_sec
Q5SY40
resolver
uniprot_sec
Q8IXV3
resolver
uniprot_sec
Q96DG3
resolver
uniprot_sec
Q96TG7
resolver
uniprot_sec
Q9NR27
resolver
uniprot_sec
Q9NSN0
resolver
uniprot_sec
Q9NV18
resolver
uniprot_sec
Q9NZ21
resolver
amino_acid_sequence
MFAKAFRVKSNTAIKGSDRRKLRADVTTAFPTLGTDQVSELVPGKEELNIVKLYAHKGDAVTVYVSGGNPILFELEKNLYPTVYTLWSYPDLLPTFTTWPLVLEKLVGGADLMLPGLVMPPAGLPQVQKGDLCAISLVGNRAPVAIGVAAMSTAEMLTSGLKGRGFSVLHTYQDHLWRSGNKSSPPSIAPLALDSADLSEEKGSVQMDSTLQGDMRHMTLEGEEENGEVHQAREDKSLSEAPEDTSTRGLNQDSTDSKTLQEQMDELLQQCFLHALKCRVKKADLPLLTSTFLGSHMFSCCPEGRQLDIKKSSYKKLSKFLQQMQQEQIIQVKELSKGVESIVAVDWKHPRITSFVIPEPSPTSQTIQEGSREQPYHPPDIKPLYCVPASMTLLFQESGHKKGSFLEGSEVRTIVINYAKKNDLVDADNKNLVRLDPILCDCILEKNEQHTVMKLPWDSLLTRCLEKLQPAYQVTLPGQEPIVKKGRICPIDITLAQRASNKKVTVVRNLEAYGLDPYSVAAILQQRCQASTTVNPAPGAKDSLQVQIQGNQVHHLGWLLLEEYQLPRKHIQGLEKALKPGKKK
uniprot
proteins
function
FUNCTION: Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. {ECO:0000269|PubMed:20566627, ECO:0000269|PubMed:20713520}.
uniprot
proteins
mass_dalton
64706
uniprot
proteins
protein_family
EIF2D family
uniprot
proteins
pubmed
12097419
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20566627
uniprot
proteins
pubmed
20713520
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2482295
uniprot
proteins
sequence_length
584
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20566627}.
uniprot
proteins