Duoxa2
entrez
66811
canonical
uniprot
Q9D311
canonical
ensembl
ENSMUSG00000027225
resolver
ensp
ENSMUSP00000028656
resolver
enst
ENSMUST00000028656
resolver
genesymbol
Duoxa2
resolver
uniprot
A2AQ98
resolver
uniprot
Q9D7U8
resolver
uniprot_entry
DOXA2_MOUSE
resolver
uniprot_sec
A2AQ98
resolver
uniprot_sec
Q9D7U8
resolver
amino_acid_sequence
MTAWDGVLPFYPQPRHAASFSVPLLIVILVFLSLAASFLFILPGIRGHSRWFWLVRVLLSLFIGAEIVAVHFSGDWFVGRVWTNTSYKAFSPSRVQVHVGLHVGLAGVNITLRGTPRQQLNETIDYNERFTWRLNEDYTKEYVHALEKGLPDPVLYLAEKFTPSSPCGLYHQYHLAGHYAAATLWVAFCFWIIANALLSMPAPLYGGLALLTTGAFTLFGVFAFASISSVPLCHFRLGSAVLTPYYGASFWLTLATGILSLLLGGAVVILHYTRPSALRSFLDLSVKDCSNQAKGNSPLTLNNPQHEQLKSPDLNITTLL
uniprot
proteins
function
FUNCTION: Required for the maturation and transport of functional DUOX2 from the endoplasmic reticulum to the plasma membrane. Recruits DUOX2 to the apical cell membrane. {ECO:0000250|UniProtKB:Q1HG44}.
uniprot
proteins
mass_dalton
35427
uniprot
proteins
post_translational_modification
PTM: N-glycosylated; this is required for DUOXA2 protein stability but not for interaction with DUOX2 or for localization of DUOX2 to the apical cell membrane. {ECO:0000250|UniProtKB:Q1HG44}.
uniprot
proteins
protein_family
DUOXA family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
320
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q1HG44}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q1HG44}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 52..72; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 184..204; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 207..227; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 250..270; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins