Insm1
entrez
53626
canonical
uniprot
Q63ZV0
canonical
ensembl
ENSMUSG00000068154
resolver
ensp
ENSMUSP00000092048
resolver
enst
ENSMUST00000089257
resolver
genesymbol
Insm1
resolver
genesymbol_syn
Ia1
resolver
uniprot
Q05BD7
resolver
uniprot
Q9Z113
resolver
uniprot_entry
INSM1_MOUSE
resolver
uniprot_entry
Q05BD7_MOUSE
resolver
uniprot_sec
Q9Z113
resolver
amino_acid_sequence
MPRGFLVKRSKKSTPVSYRVRGGEDSDRALLLSPGCGGARAEPPVPSPGPLPPPPPPALAERAHAALAAALACAPGPPPPPPPGPRAAHFGNPEAAHPAPLYSPTRPVSREHEKHKYFERSFNLGSPVSAESFPTPAALLAGGGSGANGAGGGGGGTCGGDALLFAPAELKMGTAFSAGAEAARGPGTGPPLSPAAALRPPGKRPAPPAAVATEPPAKAAKAPSAKKPKAIRKLHFEDEVTTSPVLGLKIKEGPVEAPRGRAGGATRPLGEFICQLCKEEYADPFALAQHKCSRIVRVEYRCPECAKVFSCPANLASHRRWHKPRPVPAAARAPEPEAATRAEAREAAGGGSSDRDTPSPGGVSESGSEDGLYECHHCAKKFRRQAYLRKHLLAHHQALQAKGAPPPPPPPPPPAEDILAFYAGPDEKAPQEASGDGEAAGVLGLSATAQCHLCPVCGETFPSKGAQERHLRLLHAAQVFPCKYCPATFYSSPGLTRHINKCHPSENRQVILLQVPVRPAC
uniprot
proteins
function
FUNCTION: Sequence-specific DNA-binding transcriptional regulator that plays a key role in neurogenesis and neuroendocrine cell differentiation during embryonic and/or fetal development. Binds to the consensus sequence 5'-[TG][TC][TC][TT][GA]GGG[CG]A-3' in target promoters. Acts as a transcriptional repressor of NEUROD1 and INS expression via its interaction with cyclin CCND1 in a cell cycle-independent manner. Negatively regulates skeletal muscle-specific gene expression in endocrine cells of the pituitary by inhibiting the Notch signaling pathway. Represses target gene transcription by recruiting chromatin-modifying factors, such as HDAC1, HDAC2, HDAC3, KDM1A and RCOR1 histone deacetylases. Binds to its own promoter, suggesting autoregulation as a self-control feedback mechanism. Competes with histone H3 for the same binding site on the histone demethylase complex formed by KDM1A and RCOR1, and thereby inhibits demethylation of histone H3 at 'Lys-4' (By similarity). Promotes the generation and expansion of neuronal basal progenitor cells in the developing neocortex. Involved in the differentiation of endocrine cells of the developing anterior pituitary gland, of the pancreas and intestine, and of sympatho-adrenal cells in the peripheral nervous system. Promotes cell cycle signaling arrest and inhibition of cellular proliferation. {ECO:0000250|UniProtKB:Q01101, ECO:0000269|PubMed:16511571, ECO:0000269|PubMed:16951258, ECO:0000269|PubMed:18094025, ECO:0000269|PubMed:18940587, ECO:0000269|PubMed:24227653}.
uniprot
proteins
mass_dalton
54050
uniprot
proteins
protein_family
INSM1 family
uniprot
proteins
pubmed
12079283
uniprot
proteins
pubmed
12890672
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16511571
uniprot
proteins
pubmed
16951258
uniprot
proteins
pubmed
18094025
uniprot
proteins
pubmed
18940587
uniprot
proteins
pubmed
24227653
uniprot
proteins
sequence_length
521
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12079283, ECO:0000269|PubMed:24227653}.
uniprot
proteins