Nvl
entrez
67459
canonical
uniprot
Q9DBY8
canonical
ensembl
ENSMUSG00000026516
resolver
ensp
ENSMUSP00000027797
resolver
enst
ENSMUST00000027797
resolver
genesymbol
Nvl
resolver
uniprot
Q3USC4
resolver
uniprot
Q8BW27
resolver
uniprot
Q8K2B5
resolver
uniprot_entry
NVL_MOUSE
resolver
uniprot_sec
Q3USC4
resolver
uniprot_sec
Q8BW27
resolver
uniprot_sec
Q8K2B5
resolver
amino_acid_sequence
MKPRPGVFVDRKLKQRVIQYLSSNRCGKYVDTGILASDLQRLYSVDYGRRKRNAFRIQVEKVFSIISSEKELKNLKELEDGHLAKRARQDEEDEYTESYSDDDSNMEDYPDPQSANPMNSSLLSLYRRGNSESVSTTPKWGQREATTSTPLLTSKTGSVPLKTPARESEGGWFIDKTPGGKKESLPLDLSDDQSNSKKQDSEIQILKDSSLLESDKKRKGRAKGKGNKRKTENLQEVDGEIEALLQKKAKARSTELQISNVKFEDVGGNDATLKEVCKMLIHMRHPEVYQHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVAAPEIVSGVSGESEQKLRELFDQAVSNAPCIVFIDEIDAITPKREVASKDMERRIVAQLLTCMDDLNNVAATARVLVIGATNRPDSLDPALRRAGRFDREVCLGIPDEAARERILQTLCRKLRLPETFNFCHLAHLTPGFVGADLMALCREAAMCAVNRVLMKQQAQQKKKPEIEGLPSEGDQEERLGAEPTSETQDELQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALAEVQPSAKREGFVTVPNVTWADIGALEDIRDELIMAILAPVRNPDQFRTLGLGTPAGILLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESERAVRQVFQRAKNSAPCVIFFDEVDALCPRRSDRETGASVRVVNQLLTEMDGLETRQQVFILAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRVAILKTITKNGTKPPLDEDVNLETIANDLRCNCYTGADLTALVREASLCALRQEITAQKNGVGAGELKVSHKHFEDAFKKVKPSISIKDQVMYEALQRSLSQ
uniprot
proteins
function
FUNCTION: Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Involved in both early and late stages of the pre-rRNA processing pathways. Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus. Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity. {ECO:0000250|UniProtKB:O15381}.
uniprot
proteins
mass_dalton
94476
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21474449
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
855
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:21474449}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:O15381}. Note=Associates with pre-ribosomal particles in the nucleus. {ECO:0000250|UniProtKB:O15381}.
uniprot
proteins