Mdfic
entrez
16543
canonical
uniprot
Q8BX65
canonical
ensembl
ENSMUSG00000041390
resolver
ensp
ENSMUSP00000140208
resolver
genesymbol
Mdfic
resolver
genesymbol_syn
Kdt1
resolver
uniprot
Q3T9H3
resolver
uniprot
Q6NXM1
resolver
uniprot
Q8BJS3
resolver
uniprot_entry
MDFIC_MOUSE
resolver
uniprot_sec
Q3T9H3
resolver
uniprot_sec
Q6NXM1
resolver
uniprot_sec
Q8BJS3
resolver
amino_acid_sequence
MSCAGEALAPGPAEQQCPVEAGGGRLGSPAHEACNEDNTEKDKRPATSGHTRCGLMRDQSIWPNPSAGELVRTQPERLPQLQTSAQEPGKEETGKIKNGGHTRMSNGNGIPHGAKHVSVENHKISAPVSQKMHRKIQSSLSVNNDISKKSKVNAVFSPKAASSPEDCCVHCILACLFCEFLTLCNIVLGQASCGICTSEACCCCCGDEMGDDCSCPCDMDCGIMDACCESSDCLEICMECCGICFPS
uniprot
proteins
function
FUNCTION: Required to control the activity of various transcription factors through their sequestration in the cytoplasm. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm and inhibits their transcriptional activation (PubMed:15207726, PubMed:15465018). Modulates the expression from cellular promoters. Binds to the axin complex, resulting in an increase in the level of free beta-catenin (By similarity). Affects axin-regulation of the WNT and JNK signaling pathways (By similarity). Involved in the development of lymphatic vessel valves (PubMed:35235341). Required to promote lymphatic endothelial cell migration, in a process that involves down-regulation of integrin beta 1 activation and control of cell adhesion to the extracellular matrix (By similarity). Regulates the activity of mechanosensitive Piezo channel (PubMed:37590348). {ECO:0000250|UniProtKB:Q9P1T7, ECO:0000269|PubMed:15207726, ECO:0000269|PubMed:15465018, ECO:0000269|PubMed:35235341, ECO:0000269|PubMed:37590348}.
uniprot
proteins
mass_dalton
26094
uniprot
proteins
mutagenesis
MUTAGEN 233; /note="C->A,S: Binds Piezo1 but loses the ability to regulate Piezo channel activity."; /evidence="ECO:0000269|PubMed:37590348"; MUTAGEN 237; /note="C->A,S: Binds Piezo1 but loses the ability to regulate Piezo channel activity."; /evidence="ECO:0000269|PubMed:37590348"; MUTAGEN 240; /note="C->A,S: Binds Piezo1 but loses the ability to regulate Piezo channel activity."; /evidence="ECO:0000269|PubMed:37590348"; MUTAGEN 241; /note="C->A,S: Binds Piezo1 but loses the ability to regulate Piezo channel activity."; /evidence="ECO:0000269|PubMed:37590348"; MUTAGEN 244; /note="C->A,S: Binds Piezo1 but loses the ability to regulate Piezo channel activity."; /evidence="ECO:0000269|PubMed:37590348"; MUTAGEN 245; /note="F->L: Does not affect protein expression and abundance. No effect on cell surface localization and secretion. No effect on interaction with GATA2."; /evidence="ECO:0000269|PubMed:35235341
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. {ECO:0000250|UniProtKB:Q9P1T7}.
uniprot
proteins
protein_family
MDFI family
uniprot
proteins
pubmed
15207726
uniprot
proteins
pubmed
15465018
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17891141
uniprot
proteins
pubmed
35235341
uniprot
proteins
pubmed
37590348
uniprot
proteins
sequence_length
247
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:37590348}. Secreted {ECO:0000269|PubMed:35235341}.
uniprot
proteins