PCSK2
entrez
5126
canonical
uniprot
P16519
canonical
ensembl
ENSG00000125851
resolver
ensp
ENSP00000262545
resolver
ensp
ENSP00000367131
resolver
ensp
ENSP00000437458
resolver
genesymbol
PCSK2
resolver
genesymbol_syn
NEC2
resolver
hgnc
HGNC:8744
resolver
uniprot
B1ANH9
resolver
uniprot
B4DFQ3
resolver
uniprot
Q14927
resolver
uniprot
Q5JYQ1
resolver
uniprot
Q8IWA8
resolver
uniprot
Q9NQG3
resolver
uniprot
Q9NUG1
resolver
uniprot
Q9UJC6
resolver
uniprot_entry
NEC2_HUMAN
resolver
uniprot_sec
B1ANH9
resolver
uniprot_sec
B4DFQ3
resolver
uniprot_sec
Q14927
resolver
uniprot_sec
Q5JYQ1
resolver
uniprot_sec
Q8IWA8
resolver
uniprot_sec
Q9NQG3
resolver
uniprot_sec
Q9NUG1
resolver
uniprot_sec
Q9UJC6
resolver
amino_acid_sequence
MKGGCVSQWKAAAGFLFCVMVFASAERPVFTNHFLVELHKGGEDKARQVAAEHGFGVRKLPFAEGLYHFYHNGLAKAKRRRSLHHKQQLERDPRVKMALQQEGFDRKKRGYRDINEIDINMNDPLFTKQWYLINTGQADGTPGLDLNVAEAWELGYTGKGVTIGIMDDGIDYLHPDLASNYNAEASYDFSSNDPYPYPRYTDDWFNSHGTRCAGEVSAAANNNICGVGVAYNSKVAGIRMLDQPFMTDIIEASSISHMPQLIDIYSASWGPTDNGKTVDGPRELTLQAMADGVNKGRGGKGSIYVWASGDGGSYDDCNCDGYASSMWTISINSAINDGRTALYDESCSSTLASTFSNGRKRNPEAGVATTDLYGNCTLRHSGTSAAAPEAAGVFALALEANLGLTWRDMQHLTVLTSKRNQLHDEVHQWRRNGVGLEFNHLFGYGVLDAGAMVKMAKDWKTVPERFHCVGGSVQDPEKIPSTGKLVLTLTTDACEGKENFVRYLEHVQAVITVNATRRGDLNINMTSPMGTKSILLSRRPRDDDSKVGFDKWPFMTTHTWGEDARGTWTLELGFVGSAPQKGVLKEWTLMLHGTQSAPYIDQVVRDYQSKLAMSKKEELEEELDEAVERSLKSILNKN
uniprot
proteins
ec_number
3.4.21.94
uniprot
proteins
function
FUNCTION: Serine endopeptidase which is involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues (PubMed:28719828, PubMed:7626024, PubMed:8879041, PubMed:9287128). Responsible for the release of glucagon from proglucagon in pancreatic A cells (PubMed:9287128). Mediates the release of insulin from proinsulin (PubMed:7626024). {ECO:0000269|PubMed:28719828, ECO:0000269|PubMed:7626024, ECO:0000269|PubMed:8879041, ECO:0000269|PubMed:9287128}.
uniprot
proteins
mass_dalton
70565
uniprot
proteins
protein_family
Furin subfamily
uniprot
proteins
protein_family
Peptidase S8 family
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1594602
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
2154467
uniprot
proteins
pubmed
28719828
uniprot
proteins
pubmed
7626024
uniprot
proteins
pubmed
7983775
uniprot
proteins
pubmed
8879041
uniprot
proteins
pubmed
9287128
uniprot
proteins
sequence_length
638
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle. Secreted {ECO:0000269|PubMed:28719828}. Note=Localized in the secretion granules.
uniprot
proteins