Stoml2
entrez
66592
canonical
uniprot
Q99JB2
canonical
ensembl
ENSMUSG00000028455
resolver
ensp
ENSMUSP00000030169
resolver
ensp
ENSMUSP00000117586
resolver
ensp
ENSMUSP00000306946
resolver
ensp
ENSMUSP00000328622
resolver
enst
ENSMUST00000030169
resolver
genesymbol
Stoml2
resolver
genesymbol_syn
Slp2
resolver
uniprot
Q9DCG8
resolver
uniprot_entry
STML2_MOUSE
resolver
uniprot_sec
Q9DCG8
resolver
amino_acid_sequence
MLARAARGTGALLLRGSVQASGRVPRRASSGLPRNTVILFVPQQEAWVVERMGRFHRILEPGLNVLIPVLDRIRYVQSLKEIVINVPEQSAVTLDNVTLQIDGVLYLRIMDPYKASYGVEDPEYAVTQLAQTTMRSELGKLSLDKVFRERESLNANIVDAINQAADCWGIRCLRYEIKDIHVPPRVKESMQMQVEAERRKRATVLESEGTRESAINVAEGKKQAQILASEAEKAEQINQAAGEASAVLAKAKAKAEAIRILAGALTQHNGDAAASLTVAEQYVSAFSKLAKDSNTVLLPSNPSDVTSMVAQAMGVYGALTKAPVPGAQNSSQSRRDVQATDTSIEELGRVKLS
uniprot
proteins
function
FUNCTION: Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation. {ECO:0000269|PubMed:19360003, ECO:0000269|PubMed:23028053}.
uniprot
proteins
mass_dalton
38385
uniprot
proteins
protein_family
Band 7/mec-2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16324911
uniprot
proteins
pubmed
16928863
uniprot
proteins
pubmed
19360003
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22623988
uniprot
proteins
pubmed
23028053
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
353
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22623988}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9UJZ1}. Mitochondrion {ECO:0000269|PubMed:22623988}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9UJZ1}; Lipid-anchor {ECO:0000250|UniProtKB:Q9UJZ1}. Mitochondrion intermembrane space {ECO:0000250|UniProtKB:Q9UJZ1}. Membrane raft {ECO:0000250|UniProtKB:Q9UJZ1}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9UJZ1}. Note=Behaves as an integral membrane protein of the mitochondrion despite the absence of a detectable transmembrane domain. Also associates with the actin cytoskeleton and membrane rafts in activated T-cells. A minor pool is associated with the plasma membrane and is enriched at the immunological synapse in activated T-cells. {ECO:0000250|UniProtKB:Q9UJZ1}.
uniprot
proteins