Abcg1
entrez
11307
canonical
uniprot
Q64343
canonical
ensembl
ENSMUSG00000024030
resolver
ensp
ENSMUSP00000024829
resolver
enst
ENSMUST00000024829
resolver
genesymbol
Abcg1
resolver
genesymbol_syn
Abc8
resolver
genesymbol_syn
Wht1
resolver
uniprot
Q0VDW9
resolver
uniprot_entry
ABCG1_MOUSE
resolver
uniprot_entry
Q0VDW9_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: The cholesterol efflux is enhanced by APOA1. {ECO:0000250|UniProtKB:P45844}.
uniprot
proteins
amino_acid_sequence
MACLMAAFSVGTAMNASSYSAAMTEPKSVCVSVDEVVSSNVDEVETDLLNGHLKKVDNNFTEAQRFSSLPRRAAVNIEFKDLSYSVPEGPWWKKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGMPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLPCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIVCTIHQPSAKLFELFDQLYVLSQGQCVYRGKVSNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDADYKRDLGGDTDVNPFLWHRPAEEDSASMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMSVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPAYLQWMSYISYVRYGFEGVILSIYGLDREDLHCDIAETCHFQKSEAILRELDVENAKLYLDFIVLGIFFISLRLIAYFVLRYKIRAER
uniprot
proteins
ec_number
7.6.2.-
uniprot
proteins
function
FUNCTION: Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrolysis of ATP (PubMed:14668945). The lipid efflux is ALB-dependent. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol (By similarity). {ECO:0000250|UniProtKB:P45844, ECO:0000269|PubMed:14668945}.
uniprot
proteins
mass_dalton
74033
uniprot
proteins
post_translational_modification
PTM: Palmitoylation at Cys-315 seems important for trafficking from the endoplasmic reticulum. {ECO:0000250}.
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCG family
uniprot
proteins
protein_family
Eye pigment precursor importer (TC 3.A.1.204) subfamily
uniprot
proteins
pubmed
10799558
uniprot
proteins
pubmed
11162488
uniprot
proteins
pubmed
12777468
uniprot
proteins
pubmed
14668945
uniprot
proteins
pubmed
23388354
uniprot
proteins
pubmed
8703120
uniprot
proteins
pubmed
9034316
uniprot
proteins
sequence_length
666
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P45844}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P45844}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P45844}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P45844}. Cell membrane {ECO:0000250|UniProtKB:P45844}. Note=Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes. {ECO:0000250|UniProtKB:P45844}.
uniprot
proteins
transmembrane_region
TRANSMEM 415..433; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 445..465; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 495..513; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 522..543; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 556..574; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 638..657; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins