Cd9
entrez
12527
canonical
uniprot
P40240
canonical
ensembl
ENSMUSG00000030342
resolver
ensp
ENSMUSP00000032492
resolver
enst
ENSMUST00000032492
resolver
genesymbol
Cd9
resolver
uniprot
Q3U9W0
resolver
uniprot_entry
CD9_MOUSE
resolver
uniprot_sec
Q3U9W0
resolver
amino_acid_sequence
MPVKGGSKCIKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQENNHSSFYTGVYILIGAGALMMLVGFLGCCGAVQESQCMLGLFFGFLLVIFAIEIAAAVWGYTHKDEVIKELQEFYKDTYQKLRSKDEPQRETLKAIHMALDCCGIAGPLEQFISDTCPKKQLLESFQVKPCPEAISEVFNNKFHIIGAVGIGIAVVMIFGMIFSMILCCAIRRSREMV
uniprot
proteins
function
FUNCTION: Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (PubMed:10634790, PubMed:10634791, PubMed:10700183, PubMed:14715942). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (PubMed:10634790, PubMed:10634791, PubMed:10700183, PubMed:21690351). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (PubMed:23575678). In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles. Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption (PubMed:12796480). Acts as a receptor for PSG17 (PubMed:11805154). Involved in platelet activation and aggregation (PubMed:14715942). Regulates paranodal junction formation (PubMed:14715942). Involved in cell adhesion, cell motility and tumor metastasis (By similarity). Also regulates integrin-dependent migration of macrophages, particularly relevant for inflammatory response in the lung (PubMed:18662991). {ECO:0000250|UniProtKB:P21926, ECO:0000269|PubMed:10634790, ECO:0000269|PubMed:10634791, ECO:0000269|PubMed:10700183, ECO:0000269|PubMed:11805154, ECO:0000269|PubMed:12796480, ECO:0000269|PubMed:14715942, ECO:0000269|PubMed:18662991, ECO:0000269|PubMed:21690351, ECO:0000269|PubMed:23575678}.
uniprot
proteins
mass_dalton
25258
uniprot
proteins
mutagenesis
MUTAGEN 173..175; /note="SFQ->AAA: Sperm-egg fusion abolished."; /evidence="ECO:0000269|PubMed:11934865"; MUTAGEN 174; /note="F->A: 4-fold reduction of sperm-egg fusion."; /evidence="ECO:0000269|PubMed:11934865
uniprot
proteins
post_translational_modification
PTM: Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro). The protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids. Palmitoylation by ZDHHC2 regulates CD9 expression, association with other tetraspanin family proteins and function in cell adhesion. {ECO:0000250|UniProtKB:P21926}.
uniprot
proteins
protein_family
Tetraspanin (TM4SF) family
uniprot
proteins
pubmed
10518536
uniprot
proteins
pubmed
10634790
uniprot
proteins
pubmed
10634791
uniprot
proteins
pubmed
10700183
uniprot
proteins
pubmed
11805154
uniprot
proteins
pubmed
11934865
uniprot
proteins
pubmed
12796480
uniprot
proteins
pubmed
14715942
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18662991
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21690351
uniprot
proteins
pubmed
23213457
uniprot
proteins
pubmed
23575678
uniprot
proteins
pubmed
25209248
uniprot
proteins
pubmed
26109643
uniprot
proteins
pubmed
8236164
uniprot
proteins
sequence_length
226
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10518536, ECO:0000269|PubMed:10634791, ECO:0000269|PubMed:11805154, ECO:0000269|PubMed:23213457}; Multi-pass membrane protein {ECO:0000269|PubMed:11805154}. Membrane {ECO:0000269|PubMed:11805154}; Multi-pass membrane protein {ECO:0000269|PubMed:11805154}. Secreted, extracellular exosome {ECO:0000269|PubMed:26109643}. Note=Present at the cell surface of oocytes (PubMed:10518536, PubMed:10634791, PubMed:23213457). Accumulates in the adhesion area between the sperm and egg following interaction between IZUMO1 and its receptor IZUMO1R/JUNO (PubMed:25209248). {ECO:0000269|PubMed:10518536, ECO:0000269|PubMed:10634791, ECO:0000269|PubMed:23213457, ECO:0000269|PubMed:25209248}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..33; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 54..74; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 86..109; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 194..219; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins