Nmnat3
entrez
74080
canonical
uniprot
Q99JR6
canonical
ensembl
ENSMUSG00000032456
resolver
ensp
ENSMUSP00000108557
resolver
ensp
ENSMUSP00000108559
resolver
ensp
ENSMUSP00000108560
resolver
ensp
ENSMUSP00000185773
resolver
ensp
ENSMUSP00000185779
resolver
ensp
ENSMUSP00000185780
resolver
ensp
ENSMUSP00000185781
resolver
ensp
ENSMUSP00000185788
resolver
ensp
ENSMUSP00000185789
resolver
enst
ENSMUST00000112935
resolver
enst
ENSMUST00000112937
resolver
enst
ENSMUST00000112938
resolver
genesymbol
Nmnat3
resolver
uniprot
F7BDW6
resolver
uniprot
F7BE14
resolver
uniprot
Q3V3C7
resolver
uniprot
Q3V3F1
resolver
uniprot
Q58E37
resolver
uniprot_entry
F7BDW6_MOUSE
resolver
uniprot_entry
F7BE14_MOUSE
resolver
uniprot_entry
NMNA3_MOUSE
resolver
uniprot_entry
Q3V3C7_MOUSE
resolver
uniprot_entry
Q3V3F1_MOUSE
resolver
uniprot_sec
Q58E37
resolver
activity_regulation
ACTIVITY REGULATION: Activity is strongly inhibited by galotannin. Inhibited by P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate (Nap4AD) (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MKNRIPVVLLACGSFNPITNMHLRLFEVARDHLHQTGRYQVIEGIISPVNDSYGKKDLVASHHRVAMARLALQTSDWIRVDPWESEQAQWMETVKVLRHHHRELLRSSAQMDGPDPSKTPSASAALPELKLLCGADVLKTFQTPNLWKDTHIQEIVEKFGLVCVSRSGHDPERYISDSPILQQFQHNIHLAREPVLNEISATYVRKALGQGQSVKYLLPEAVITYIRDQGLYINDGSWKGKGKTG
uniprot
proteins
ec_number
2.7.7.1
uniprot
proteins
ec_number
2.7.7.18
uniprot
proteins
function
FUNCTION: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (By similarity). Protects against axonal degeneration following injury (PubMed:16914673). May be involved in the maintenance of axonal integrity (PubMed:22425156). Also functions as a stress-response chaperone protein that prevents toxic aggregation of proteins; this function may be independent of its NAD(+) synthesis activity (By similarity). {ECO:0000250|UniProtKB:Q96T66, ECO:0000269|PubMed:16914673, ECO:0000269|PubMed:22425156}.
uniprot
proteins
mass_dalton
27703
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1.; PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.
uniprot
proteins
protein_family
Eukaryotic NMN adenylyltransferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16914673
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22425156
uniprot
proteins
sequence_length
245
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16914673}.
uniprot
proteins