Josd1
entrez
74158
canonical
uniprot
Q9DBJ6
canonical
ensembl
ENSMUSG00000022426
resolver
ensp
ENSMUSP00000023061
resolver
enst
ENSMUST00000023061
resolver
genesymbol
Josd1
resolver
uniprot
Q3U3E9
resolver
uniprot_entry
JOS1_MOUSE
resolver
uniprot_sec
Q3U3E9
resolver
amino_acid_sequence
MSCVPWKGDKAKAESSDLPQAAPPQIYHEKQRRELCALHALNNVFQDSNAFTRETLQEIFQRLSPNTMVTPHKKSMLGNGNYDVNVIMAALQTKGYEAVWWDKRRDVGVIALTNVMGFIMNLPSSLCWGPLKLPLKRQHWICVREVGGAYYNLDSKLKMPEWIGGESELRKFLKYHLRGKNCELLLVVPEEVEAHQSWRADV
uniprot
proteins
ec_number
3.4.19.12
uniprot
proteins
function
FUNCTION: Deubiquitinates monoubiquitinated probes (in vitro). When ubiquitinated, cleaves 'Lys-63'-linked and 'Lys-48'-linked poly-ubiquitin chains (in vitro), hence may act as a deubiquitinating enzyme. May increase macropinocytosis and suppress clathrin- and caveolae-mediated endocytosis. May enhance membrane dynamics and cell motility independently of its catalytic activity (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
23152
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated. Ubiquitination activates deubiquitination activity in vitro. {ECO:0000269|PubMed:23625928}.
uniprot
proteins
pubmed
12486728
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23625928
uniprot
proteins
sequence_length
202
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Ubiquitination increases localization the plasma membrane. In the cytosol, the unubiquitinated form may be associated with the cytoskeleton via ACTB-binding. {ECO:0000250}.
uniprot
proteins