O60774
uniprot
O60774
canonical
amino_acid_sequence
MSKRVGIIGAGVSGLAAIWCCLEEGLEPTCFERSDDVGGLWKFSDHTEEGRASIYQSVFTNSSKEMMCFPDFPYPDDYPNYIHHSKLQEYIKTYAQKKDLLRYIQFETLVSGIKKCPSFLVTGQWVVVTEKDGKQESTIFDAVMICSGHHVYPNLPTDSFPGLDQFRGNYLHSRDYKNPEAFKGKRVLVIGLGNSGSDIAVELSRLATQVIISTRSASWVMSRVWDDGYPWDMMYVTRFASFLRNVLPSFISDWLYVQKMNTWFKHENYGLMPLNGSLRKEPVFNDELPSRILCGTLSIKPSVKEFTETSAVFEDGTMFEAIDSVIFATGYDYSYPFLDETIMKSRNNEVTLFKGIFPPLMEKPTLAVIGLVQSLGAAIPTADLQAWWAAKVFANSCTLPTTNEMMDDTDEKMGKKLKCMFSSFFMFGQSQTLQTDYITYVDELGSFIGAKPNIPWLFLTDPRLALEVYFGPCSPYQFRLMGPGKWDGARNAILTQWNRTVKPTRTRVVSEVQRPHPFYNLLKMLSFPLLLLAVTLTFY
uniprot
proteins
function
FUNCTION: Member of the flavin-containing monooxygenase (FMO) family of NADPH-dependent monooxygenases, which catalyze the oxygenation of nucleophilic heteroatom-containing compounds such as xenobiotics and drugs. In humans, FMO6 is unlikely to encode a functional monooxygenase due to defective transcript processing and the presence of truncating variants. No enzymatic activity has been demonstrated for the human protein. {ECO:0000269|PubMed:12130684, ECO:0000269|PubMed:12527699}.
uniprot
proteins
mass_dalton
61291
uniprot
proteins
protein_family
FMO family
uniprot
proteins
pubmed
12130684
uniprot
proteins
pubmed
12527699
uniprot
proteins
pubmed
16710414
uniprot
proteins
sequence_length
539
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 518..538; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins