Cnga1
entrez
12788
canonical
uniprot
P29974
canonical
ensembl
ENSMUSG00000067220
resolver
ensp
ENSMUSP00000084464
resolver
ensp
ENSMUSP00000132329
resolver
ensp
ENSMUSP00000143881
resolver
enst
ENSMUST00000087213
resolver
enst
ENSMUST00000169997
resolver
enst
ENSMUST00000201463
resolver
genesymbol
Cnga1
resolver
genesymbol_syn
Cncg
resolver
genesymbol_syn
Cncg1
resolver
uniprot
B9EJ09
resolver
uniprot
Q60776
resolver
uniprot_entry
CNGA1_MOUSE
resolver
uniprot_sec
B9EJ09
resolver
uniprot_sec
Q60776
resolver
amino_acid_sequence
MKTNIINTWHSFVNIPNVIVPAIEKEIRRMENGACSSFSDDDNGSLSEESENEDSFFRSNSYKRRGPSQREQHLPGTMALFNVNNSSNKDQEPKEKKKKKKEKKSKADDKNENKKDPEKKKKKEKEKEKKKKEEKTKEKKEEEKKEVVVIDPSGNTYYNWLFCITLPVMYNWTMIIARACFDELQSDYLEYWLIFDYVSDVVYLADMFVRTRTGYLEQGLLVKDRMKLIEKYKANLQFKLDVLSVIPTDLLYIKFGWNYPEIRLNRLLRISRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVYYSISKAIGFGNDTWVYPDVNDPEFGRLARKYVYSLYWSTLTLTTIGETPPPVLDSEYIFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQSRVDAIKQYMNFRNVSKDMEKRVIKWFDYLWTNKKTVDEREVLRYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGITQFVVLSDGSYFGEISILNIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGRQILMKDGLLDINIANMGSDPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRLTKVEKFLKPLIETEFSALEEPGGESELTESLQD
uniprot
proteins
function
FUNCTION: Pore-forming subunit of the rod cyclic nucleotide-gated channel. Mediates rod photoresponses at dim light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade. Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations. The selectivity for Ca(2+) over Na(+) increases with cGMP concentrations, whereas the selectivity among monovalent ions is independent of the cGMP levels. {ECO:0000250|UniProtKB:P29973, ECO:0000250|UniProtKB:Q00194}.
uniprot
proteins
mass_dalton
79460
uniprot
proteins
protein_family
CNGA1 subfamily
uniprot
proteins
protein_family
Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family
uniprot
proteins
pubmed
11764791
uniprot
proteins
pubmed
1372902
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15634774
uniprot
proteins
pubmed
7540868
uniprot
proteins
sequence_length
684
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Photoreceptor outer segment membrane {ECO:0000269|PubMed:15634774}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:P29973}; Multi-pass membrane protein {ECO:0000255}. Note=Localized in rod outer segment membranes. {ECO:0000269|PubMed:15634774}.
uniprot
proteins
transmembrane_region
TRANSMEM 162..183; /note="Helical; Name=S1"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 194..214; /note="Helical; Name=S2"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 240..258; /note="Helical; Name=S3"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 264..282; /note="Helical; Name=S4"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 290..313; /note="Helical; Name=S5"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 337..371; /note="Helical; Name=P-helix"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 372..396; /note="Helical; Name=S6"; /evidence="ECO:0000250|UniProtKB:P29973
uniprot
proteins