Clpb
entrez
20480
canonical
uniprot
Q60649
canonical
ensembl
ENSMUSG00000001829
resolver
ensp
ENSMUSP00000001884
resolver
ensp
ENSMUSP00000102611
resolver
ensp
ENSMUSP00000148062
resolver
enst
ENSMUST00000001884
resolver
enst
ENSMUST00000106998
resolver
enst
ENSMUST00000209579
resolver
genesymbol
Clpb
resolver
genesymbol_syn
Skd3
resolver
uniprot
A0A1B0GST4
resolver
uniprot
E9PY58
resolver
uniprot
Q3URM1
resolver
uniprot
Q8CCN6
resolver
uniprot_entry
A0A1B0GST4_MOUSE
resolver
uniprot_entry
CLPB_MOUSE
resolver
uniprot_entry
E9PY58_MOUSE
resolver
uniprot_entry
Q3URM1_MOUSE
resolver
uniprot_entry
Q8CCN6_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Disaggregase activity is inhibited by ADP. {ECO:0000250|UniProtKB:Q9H078}.
uniprot
proteins
amino_acid_sequence
MMLSAVLRRTTPAPRLFLGLIKSPSLQSRGGAYGRGVVTGDRGEPQRLRAAAWVRPGASSTFVPGRGAATWGRRGERTEIPYLTAASSERGPSPEETLPGQDSWNGVPNKTGLGMWALAMALVVQCYSKNPSNKDAALMEAARANNVQEVRRLLSEGADVNARHKLGWTALMVASISHNESVVQVLLAAGADPNLGDEFSSVYKTANEQGVHSLEVLVTREDDFNNRLNHRASFKGCTALHYAVLADDYSIVKELLDRGANPLQRNEMGHTPLDYAREGEVMKLLKTSETKYMEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVFLFLGSSGIGKTELAKQTAKYMHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYIGHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQLFDEGRLTDGKGKTIDCKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDVQMSDKITISKNFKENVIRPILKAHFRRDEFLGRINEIVYFLPFCHSELIQLVNKELNFWAKRAKQRHNITLLWDREVADVLVDGYNVHYGARSIKHEVERRVVNQLAAAYEQDLLPGGCTLRITVEDSDKHLLKSPELPSPQAEKRPPTLRLEIIDKDSKTRKLDIQAPLHPEKVCYTI
uniprot
proteins
ec_number
3.6.1.-
uniprot
proteins
function
FUNCTION: Functions as a regulatory ATPase and participates in secretion/protein trafficking process. Has ATP-dependent protein disaggregase activity and is required to maintain the solubility of key mitochondrial proteins. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6. Plays a role in granulocyte differentiation. {ECO:0000250|UniProtKB:Q9H078}.
uniprot
proteins
mass_dalton
76004
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved by protease PARL. ATP-dependent protein disaggregase activity is stimulated by PARL-mediated cleavage of the N-terminal autoinhibitory peptide. {ECO:0000250|UniProtKB:Q9H078}.
uniprot
proteins
protein_family
ClpA/ClpB family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7835694
uniprot
proteins
sequence_length
677
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000250|UniProtKB:Q9H078}.
uniprot
proteins