Fbxl21
entrez
213311
canonical
uniprot
Q8BFZ4
canonical
ensembl
ENSMUSG00000035509
resolver
ensp
ENSMUSP00000035248
resolver
ensp
ENSMUSP00000112518
resolver
ensp
ENSMUSP00000112714
resolver
enst
ENSMUST00000121095
resolver
enst
ENSMUST00000121871
resolver
genesymbol
Fbxl21
resolver
genesymbol_syn
Fbl21
resolver
genesymbol_syn
Fbxl3b
resolver
uniprot
A0A0R4J1M5
resolver
uniprot
B2RSN8
resolver
uniprot
G3X9Y3
resolver
uniprot
Q8BIJ8
resolver
uniprot
Q8BIW5
resolver
uniprot_entry
A0A0R4J1M5_MOUSE
resolver
uniprot_entry
FXL21_MOUSE
resolver
uniprot_entry
G3X9Y3_MOUSE
resolver
uniprot_sec
B2RSN8
resolver
uniprot_sec
Q8BIJ8
resolver
uniprot_sec
Q8BIW5
resolver
amino_acid_sequence
MKRNNFSAVNKVVQSSPVVKQPKRGLCSSLRQTHALSVLLDWGTLPHHVILQIFQYLPLIDRARASSVCRRWNEVFHIPDLWRKFEFELNQSATSYFKSTHPDLIQQIIKKHAAHLQYVSFKVDSSTESAEAACDILSQLVNCSIQTLGLISTAKPSFMNVPKSHFVSALTVVFVNSKSLSSIKIEDTPVDDPSLKILVANNSDTLRLLKMSSCPHVSSDGILCVADHCQGLRELALNYYILSDEILLALSSETHVNLEHLRIDVVSENPGQIKFHSIKKRSWDALIKHSPRVNVVMYFFLYEEEFEAFFKEETPVTHLYFGRSVSRAILGRIGLNCPRLIELVVCANGLLPLDSELIRIAKHCKNLTSLGLSECEVSCSAFVEFVRLCGRRLTQLSIMEEVLVPDDRYTPDEVHTEVSKHLGRVWFPDVMPIW
uniprot
proteins
function
FUNCTION: Substrate-recognition component of the SCF(FBXL21) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL21) complex mainly acts in the cytosol and mediates ubiquitination of CRY proteins (CRY1 and CRY2), leading to CRY proteins stabilization. The SCF(FBXL21) complex counteracts the activity of the SCF(FBXL3) complex and protects CRY proteins from degradation. Involved in the hypothalamic suprachiasmatic nucleus (SCN) clock regulating temporal organization of the daily activities. {ECO:0000269|PubMed:18953409, ECO:0000269|PubMed:23452855, ECO:0000269|PubMed:23452856}.
uniprot
proteins
mass_dalton
49154
uniprot
proteins
mutagenesis
MUTAGEN 149; /note="G->E: In Past-time (Psttm) mutant; causes period shortening due to Cry1 and Cry2 destabilization."; /evidence="ECO:0000269|PubMed:23452855
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18953409
uniprot
proteins
pubmed
23452855
uniprot
proteins
pubmed
23452856
uniprot
proteins
sequence_length
434
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol. Nucleus. Note=Mainly localizes in the cytosol. Present at low level in the nucleus.
uniprot
proteins