Rnf138
entrez
56515
canonical
uniprot
Q9CQE0
canonical
ensembl
ENSMUSG00000024317
resolver
ensp
ENSMUSP00000072626
resolver
ensp
ENSMUSP00000157047
resolver
ensp
ENSMUSP00000157102
resolver
ensp
ENSMUSP00000157123
resolver
ensp
ENSMUSP00000286536
resolver
ensp
ENSMUSP00000286541
resolver
genesymbol
Rnf138
resolver
genesymbol_syn
Trif
resolver
uniprot
Q9CSA3
resolver
uniprot
Q9WTR9
resolver
uniprot
Q9WTS0
resolver
uniprot_entry
Q9CSA3_MOUSE
resolver
uniprot_entry
RN138_MOUSE
resolver
uniprot_sec
Q9WTR9
resolver
uniprot_sec
Q9WTS0
resolver
amino_acid_sequence
MSEELSAATSYTEDDFYCPVCQEVLKTPVRTAACQHVFCRKCFLTAMRESGIHCPLCRGSVTRRERACPERALDLENIMRRFSGSCRCCSKKIKFYRMRHHYKSCKKYQDEYGVSSVIPNFKISQDSVRSSNRSETSASDNTETYQEDTSSSGHPTFKCPLCQESNFTRQRLLDHCNSNHLFQIVPVTCPICVSLPWGDPSQITRNFVSHLNQRHQFDYGEFVNLQLDEETQYQTAVEESFQVNM
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination. Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination. Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination. According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway. {ECO:0000250|UniProtKB:Q8WVD3}.
uniprot
proteins
mass_dalton
28299
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q8WVD3}.
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated. {ECO:0000250|UniProtKB:Q8WVD3}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
245
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q8WVD3}. Note=Recruited at DNA damage sites. Localizes to sites of double-strand break: localization to double-strand break sites is mediated by the zinc fingers. {ECO:0000250|UniProtKB:Q8WVD3}.
uniprot
proteins