CD14
entrez
929
canonical
uniprot
P08571
canonical
ensembl
ENSG00000170458
resolver
ensp
ENSP00000304236
resolver
ensp
ENSP00000425447
resolver
ensp
ENSP00000426543
resolver
ensp
ENSP00000430884
resolver
enst
ENST00000302014
resolver
enst
ENST00000498971
resolver
enst
ENST00000512545
resolver
enst
ENST00000519715
resolver
genesymbol
CD14
resolver
hgnc
HGNC:1628
resolver
uniprot
Q53XT5
resolver
uniprot
Q96FR6
resolver
uniprot
Q96L99
resolver
uniprot
Q9UNS3
resolver
uniprot_entry
CD14_HUMAN
resolver
uniprot_sec
Q53XT5
resolver
uniprot_sec
Q96FR6
resolver
uniprot_sec
Q96L99
resolver
uniprot_sec
Q9UNS3
resolver
amino_acid_sequence
MERASCLLLLLLPLVHVSATTPEPCELDDEDFRCVCNFSEPQPDWSEAFQCVSAVEVEIHAGGLNLEPFLKRVDADADPRQYADTVKALRVRRLTVGAAQVPAQLLVGALRVLAYSRLKELTLEDLKITGTMPPLPLEATGLALSSLRLRNVSWATGRSWLAELQQWLKPGLKVLSIAQAHSPAFSCEQVRAFPALTSLDLSDNPGLGERGLMAALCPHKFPAIQNLALRNTGMETPTGVCAALAAAGVQPHSLDLSHNSLRATVNPSAPRCMWSSALNSLNLSFAGLEQVPKGLPAKLRVLDLSCNRLNRAPQPDELPEVDNLTLDGNPFLVPGTALPHEGSMNSGVVPACARSTLSVGVSGTLVLLQGARGFA
uniprot
proteins
function
FUNCTION: Coreceptor for bacterial lipopolysaccharide (PubMed:1698311, PubMed:23264655). In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:20133493, PubMed:22265692, PubMed:23264655). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (PubMed:23880187). {ECO:0000269|PubMed:16880211, ECO:0000269|PubMed:1698311, ECO:0000269|PubMed:20133493, ECO:0000269|PubMed:22265692, ECO:0000269|PubMed:23264655, ECO:0000269|PubMed:23880187, ECO:0000269|PubMed:8612135}.
uniprot
proteins
mass_dalton
40076
uniprot
proteins
post_translational_modification
PTM: N- and O- glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan. {ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169}.
uniprot
proteins
pubmed
11274165
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
16880211
uniprot
proteins
pubmed
1698311
uniprot
proteins
pubmed
1718034
uniprot
proteins
pubmed
18810425
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19838169
uniprot
proteins
pubmed
20133493
uniprot
proteins
pubmed
22265692
uniprot
proteins
pubmed
23264655
uniprot
proteins
pubmed
23880187
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2453848
uniprot
proteins
pubmed
2462937
uniprot
proteins
pubmed
2472171
uniprot
proteins
pubmed
25497142
uniprot
proteins
pubmed
25965346
uniprot
proteins
pubmed
2779588
uniprot
proteins
pubmed
3385210
uniprot
proteins
pubmed
8612135
uniprot
proteins
sequence_length
375
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1698311, ECO:0000269|PubMed:2462937, ECO:0000269|PubMed:3385210}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:1698311, ECO:0000269|PubMed:2462937, ECO:0000269|PubMed:3385210}. Secreted {ECO:0000269|PubMed:25497142, ECO:0000269|PubMed:2779588}. Membrane raft {ECO:0000269|PubMed:16880211}. Golgi apparatus {ECO:0000269|PubMed:16880211}. Note=Secreted forms may arise by cleavage of the GPI anchor. {ECO:0000269|PubMed:2462937, ECO:0000269|PubMed:2779588, ECO:0000269|PubMed:3385210}.
uniprot
proteins