Nucb2
entrez
59295
canonical
uniprot
Q9JI85
canonical
ensembl
ENSRNOG00000020456
resolver
ensembl
ENSRNOG00055006787
resolver
ensembl
ENSRNOG00060017872
resolver
ensembl
ENSRNOG00065029150
resolver
ensp
ENSRNOP00000027753
resolver
ensp
ENSRNOP00055008730
resolver
ensp
ENSRNOP00060025035
resolver
ensp
ENSRNOP00065041535
resolver
enst
ENSRNOT00055011151
resolver
enst
ENSRNOT00060030920
resolver
enst
ENSRNOT00065050545
resolver
genesymbol
Nucb2
resolver
genesymbol_syn
Nefa
resolver
uniprot_entry
NUCB2_RAT
resolver
amino_acid_sequence
MRWRTIQARYCFLLVPCVLTALEAVPIDVDKTKVHNVEPVESARIEPPDTGLYYDEYLKQVIEVLETDPHFREKLQKADIEEIRSGRLSQELDLVSHKVRTRLDELKRQEVGRLRMLIKAKLDALQDTGMNHHLLLKQFEHLNHQNPDTFESKDLDMLIKAATADLEQYDRTRHEEFKKYEMMKEHERREYLKTLSEEKRKEEEAKFAEMKRKHEDHPKVNHPGSKDQLKEVWEETDGLDPNDFDPKTFFKLHDVNNDGFLDEQELEALFTKELDKVYNPQNAEDDMIEMEEERLRMREHVMNEIDNNKDRLVTLEEFLRATEKKEFLEPDSWETLDQQQLFTEEELKEYESIIAIQESELKKKADELQKQKEELQRQHDHLEAQKQEYQQAVQQLEQKKFQQGIAPSGPAGELKFEPHT
uniprot
proteins
function
FUNCTION: Calcium-binding protein which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G protein) alpha subunit GNAI3 (PubMed:21653697). {ECO:0000250|UniProtKB:P81117, ECO:0000269|PubMed:21653697}.; FUNCTION: [Nesfatin-1]: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance. In intestinal epithelial cells, plays a role in the inhibition of hepatic glucose production via MC4R receptor leading to increased cyclic adenosine monophosphate (cAMP) levels and glucagon-like peptide 1 (GLP-1) secretion (By similarity). {ECO:0000250|UniProtKB:P80303, ECO:0000269|PubMed:17036007, ECO:0000269|PubMed:22293188}.
uniprot
proteins
mass_dalton
50090
uniprot
proteins
mutagenesis
MUTAGEN 315; /note="L->A: Abolishes binding to and activation of GNAI3; when associated with A-319."; /evidence="ECO:0000269|PubMed:21653697"; MUTAGEN 318; /note="F->A: Abolishes binding to and activation of GNAI3."; /evidence="ECO:0000269|PubMed:21653697"; MUTAGEN 319; /note="L->A: Abolishes binding to and activation of GNAI3; when associated with A-315."; /evidence="ECO:0000269|PubMed:21653697
uniprot
proteins
protein_family
Nucleobindin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17036007
uniprot
proteins
pubmed
21653697
uniprot
proteins
pubmed
22293188
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
420
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Nucleus envelope {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Secreted {ECO:0000250}.; SUBCELLULAR LOCATION: [Nesfatin-1]: Secreted.
uniprot
proteins