Rab3gap2
entrez
289350
canonical
uniprot
Q5U1Z0
canonical
ensembl
ENSRNOG00000002353
resolver
ensp
ENSRNOP00000038422
resolver
genesymbol
Rab3gap2
resolver
uniprot_entry
RBGPR_RAT
resolver
amino_acid_sequence
MACSIVQFCSFQDLQSARDFLFPQLREETPGALRRDPSKTSNWEDDSWGAWEETEPQEPEEEGNTSKTQKHSWLQECVLSLSPTSDLMVIAREQKAAFLVRKWKHSDKGKEEMQFAVGWSGSVSAEEGEYVTSALCIPLASQKRSSTGRPDWTCIVVGFTSGYVRFYTEGVLLLAQLLNEDRVLQLKCRTYEIPRHPGVTEQNEELSILYPAAIVTIDGFSLFQSLRACRNQVAKAAASGNENIQPPPLAYKKWGLQDIDTIIDHASIGIMTLSPFDQMKTASNIGGFNAAIKNSPPAMSQYITVGSSPFTGFFYALEGSTQPLLSHVALAVASKLTSALFSAASGWLGWKSKHEEETVQKQKPKMEPATPLAVRFGLPDSRRHGESICLSPCNTLAAVTDDFGRVILLDVARGIAIRMWKGYRDAQIGWIQIVEDLHERVPEKGDFSPFGNTQGPSRVAQFLVIYAPRRGILEVWSTQQGPRVGAFNVGKHCRLLYPGYKIMGLNNVTSQSWQPQTYQICLVDPVSASVKAVNVPFHLALSDKKSERAKDLHLVKKLAALLRAKSPRPDSFEAEIKELILDIKYPATKKQALESILASDRVSFSCLRNVTQTSMDTLKNQELESVDEGLLQFCASKLKLLHLYESVSQLNTLDFHSDTPFSDNDLAVLLRLDDKELLKLRALLEKYKQENTKATVRFSEDADGVLPVKTFLEYLDYEKDALSIRKTSEEECVALGSFFFWKCLHGESSTEDMCHTLESAGLSPQQLLSLLLSVWLSKEKDILDKPQSVCCLHTMLSLLSKMKVAIDETWDSQSVSPWWQQMRMACIQSENNGAALLSAHVGHSVAAQMSSSATDKKFSQMVLDADAEALTDSWEALSLDTEYWKLLLRQLEDCLILQTLLHSRASPPAAKASSPQTEPLPRLSVKKLLEGGKGGIADSVAKWIFKQDLSPELLKCANREKDVENPDEPREGIARSPPEVSEVETDLGAVPDLLRLAYEQFPCSLELDVLHAHCCWEYVVQWNKDPEEARFLVRSIEHLRHILNPHVQNGISLMMWNTFLVKRFSAATYLMDKVGKSPKDRLCRRDVGMSDTALTSFLGSCLDLLQTSLEADISRDEVQVPVLDTEDAWLSVEGPTSIVELALEQKPIHYPLVEHHSILCSILYAAMSFSLKSVKPLALFDSKGKNAFFKDLTSIQLLPSGEMDPNFISVRQQFLLKVVSAAVQAQHSKDKDPSARAADTHGQDLNWTALAVDLAHHLQVSEDVIRRHYVGELYSYGADLLGEEAILQVQDKEVLASQLLVLTGQRLAHALFHTQTKEGMELLARLPPTLCTWLKAMNPQDLQNTGVPVAATAKLVHKVMELLPEKHGQYSLALHLIEAVEAMATL
uniprot
proteins
function
FUNCTION: Regulatory subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which accelerates the otherwise slow GTP hydrolysis catalyzed by Rab proteins. The complex has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and has guanine nucleotide exchange factor (GEF) activity towards RAB18. The Rab3GAP complex acts as a GEF for RAB18 by promoting GDP release from RAB18 and the conversion of inactive RAB18-GDP to the active form RAB18-GTP. Recruits and stabilizes RAB18 at the cis-Golgi membrane in human fibroblasts where RAB18 is most likely activated. Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure (By similarity). Required for normal eye and brain development (By similarity). May participate in neurodevelopmental processes such as cell proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters (By similarity). {ECO:0000250|UniProtKB:Q15042, ECO:0000250|UniProtKB:Q9H2M9}.
uniprot
proteins
mass_dalton
154431
uniprot
proteins
protein_family
Rab3-GAP regulatory subunit family
uniprot
proteins
pubmed
11809763
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9733780
uniprot
proteins
sequence_length
1386
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9733780}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9H2M9}. Note=In neurons, it is enriched in the synaptic soluble fraction. {ECO:0000269|PubMed:9733780}.
uniprot
proteins