C1qtnf12
entrez
67389
canonical
uniprot
Q8R2Z0
canonical
ensembl
ENSMUSG00000023571
resolver
ensp
ENSMUSP00000024338
resolver
enst
ENSMUST00000024338
resolver
genesymbol
C1qtnf12
resolver
genesymbol_syn
C1qdc2
resolver
genesymbol_syn
Ctrp12
resolver
genesymbol_syn
Fam132a
resolver
uniprot
Q9CQI8
resolver
uniprot_entry
ADIPL_MOUSE
resolver
uniprot_sec
Q9CQI8
resolver
amino_acid_sequence
MWAWGWAAAALLWLQTAGAGARQELKKSRQLFARVDSPNITTSNREGFPGSVKPPEASGPELSDAHMTWLNFVRRPDDGSSRKRCRGRDKKSRGLSGLPGPPGPPGPPGPPGSPGVGVTPEALLQEFQEILKEATELRFSGLPDTLLPQEPSQRLVVEAFYCRLKGPVLVDKKTLVELQGFQAPTTQGAFLRGSGLSLSLGRFTAPVSAIFQFSASLHVDHSELQGRGRLRTRDMVRVLICIESLCHRHTSLEAVSGLESNSRVFTVQVQGLLHLQSGQYVSVFVDNSSGAVLTIQNTSSFSGMLLGT
uniprot
proteins
function
FUNCTION: Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue (PubMed:21849507, PubMed:22275362). {ECO:0000269|PubMed:21849507, ECO:0000269|PubMed:22275362}.; FUNCTION: [Adipolin fC1QTNF12]: Acts by activating the Akt signaling in hepatocytes and adipocytes. Not able to increase insulin-stimulated glucose uptake in adipocytes (PubMed:22942287). {ECO:0000269|PubMed:22942287}.; FUNCTION: [Adipolin gC1QTNF12]: Acts by activating the MAP kinase. Increases insulin-stimulated glucose uptake in adipocytes (PubMed:22942287). {ECO:0000269|PubMed:22942287}.
uniprot
proteins
mass_dalton
33267
uniprot
proteins
mutagenesis
MUTAGEN 39; /note="N->A: Decreased N-glycosylation."; /evidence="ECO:0000269|PubMed:22942287"; MUTAGEN 85; /note="C->A: Abolishes multimeric complex formation."; /evidence="ECO:0000269|PubMed:22942287"; MUTAGEN 90..93; /note="KKSR->AASA: Nearly abolishes protein processing."; /evidence="ECO:0000269|PubMed:22942287, ECO:0000269|PubMed:23068097"; MUTAGEN 90..93; /note="Missing: Abolishes protein processing."; /evidence="ECO:0000269|PubMed:22942287, ECO:0000269|PubMed:23068097"; MUTAGEN 93; /note="R->A: Enhances protein processing."; /evidence="ECO:0000269|PubMed:22942287
uniprot
proteins
post_translational_modification
PTM: Processed into Adipolin fC1QTNF12 and Adipolin gC1QTNF12 by FURIN (PubMed:22942287). Insulin enhances endogenous C1QTNF12 cleavage (PubMed:22942287). {ECO:0000269|PubMed:22942287}.
uniprot
proteins
protein_family
Adipolin/erythroferrone family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21849507
uniprot
proteins
pubmed
22275362
uniprot
proteins
pubmed
22351773
uniprot
proteins
pubmed
22942287
uniprot
proteins
pubmed
23068097
uniprot
proteins
pubmed
23633521
uniprot
proteins
pubmed
24358263
uniprot
proteins
sequence_length
308
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Adipolin fC1QTNF12]: Secreted {ECO:0000269|PubMed:22275362, ECO:0000269|PubMed:22942287}.; SUBCELLULAR LOCATION: [Adipolin gC1QTNF12]: Secreted {ECO:0000269|PubMed:22275362, ECO:0000269|PubMed:22942287}. Note=In serum is the predominant form. {ECO:0000269|PubMed:22275362}.
uniprot
proteins