POGLUT2
entrez
79070
canonical
uniprot
Q6UW63
canonical
ensembl
ENSG00000134901
resolver
ensp
ENSP00000365172
resolver
ensp
ENSP00000516430
resolver
enst
ENST00000376004
resolver
enst
ENST00000706521
resolver
genesymbol
POGLUT2
resolver
genesymbol_syn
EP58
resolver
genesymbol_syn
KDELC1
resolver
hgnc
HGNC:19350
resolver
uniprot
A0A9L9PXM5
resolver
uniprot
Q53HL3
resolver
uniprot
Q9BVD2
resolver
uniprot_entry
A0A9L9PXM5_HUMAN
resolver
uniprot_entry
PLGT2_HUMAN
resolver
uniprot_sec
Q53HL3
resolver
uniprot_sec
Q9BVD2
resolver
amino_acid_sequence
MFGTLLLYCFFLATVPALAETGGERQLSPEKSEIWGPGLKADVVLPARYFYIQAVDTSGNKFTSSPGEKVFQVKVSAPEEQFTRVGVQVLDRKDGSFIVRYRMYASYKNLKVEIKFQGQHVAKSPYILKGPVYHENCDCPLQDSAAWLREMNCPETIAQIQRDLAHFPAVDPEKIAVEIPKRFGQRQSLCHYTLKDNKVYIKTHGEHVGFRIFMDAILLSLTRKVKMPDVELFVNLGDWPLEKKKSNSNIHPIFSWCGSTDSKDIVMPTYDLTDSVLETMGRVSLDMMSVQANTGPPWESKNSTAVWRGRDSRKERLELVKLSRKHPELIDAAFTNFFFFKHDENLYGPIVKHISFFDFFKHKYQINIDGTVAAYRLPYLLVGDSVVLKQDSIYYEHFYNELQPWKHYIPVKSNLSDLLEKLKWAKDHDEEAKKIAKAGQEFARNNLMGDDIFCYYFKLFQEYANLQVSEPQIREGMKRVEPQTEDDLFPCTCHRKKTKDEL
uniprot
proteins
ec_number
2.4.1.-
uniprot
proteins
ec_number
2.4.2.-
uniprot
proteins
function
FUNCTION: Protein glucosyltransferase that catalyzes the transfer of glucose from UDP-glucose to a serine residue within the consensus sequence peptide C-X-N-T-X-G-S-F-X-C (PubMed:30127001). Can also catalyze the transfer of xylose from UDP-xylose but less efficiently (PubMed:30127001). Specifically targets extracellular EGF repeats of proteins such as NOTCH1, NOTCH3, FBN1, FBN2 and LTBP1 (PubMed:30127001, PubMed:34411563). May regulate the transport of NOTCH1 and NOTCH3 to the plasma membrane and thereby the Notch signaling pathway (PubMed:30127001). {ECO:0000269|PubMed:30127001, ECO:0000269|PubMed:34411563}.
uniprot
proteins
mass_dalton
58043
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:30127001}.
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q9JHP7}.
uniprot
proteins
protein_family
KDELC family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
30127001
uniprot
proteins
pubmed
34411563
uniprot
proteins
sequence_length
502
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
uniprot
proteins