Spink2
entrez
408234
canonical
uniprot
Q6IE49
canonical
ensembl
ENSRNOG00000066503
resolver
ensp
ENSRNOP00000093491
resolver
enst
ENSRNOT00000114126
resolver
genesymbol
Spink2
resolver
uniprot
A0A650C5B7
resolver
uniprot_entry
A0A650C5B7_RAT
resolver
uniprot_entry
ISK2_RAT
resolver
amino_acid_sequence
MLRLVLLLLATDFAASDDSLDSSDSQLIKRSQFRTPDCHRFDYPVCSKHLSPVCGTDMNTYGNECTLCMKIREDGSHINIIKDEPC
uniprot
proteins
function
FUNCTION: As a strong inhibitor of acrosin, it is required for normal spermiogenesis. It probably hinders premature activation of proacrosin and other proteases, thus preventing the cascade of events leading to spermiogenesis defects. May be involved in the regulation of serine protease-dependent germ cell apoptosis. It also inhibits trypsin. {ECO:0000250|UniProtKB:Q8BMY7}.
uniprot
proteins
mass_dalton
9697
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15060002
uniprot
proteins
sequence_length
86
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P20155}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q8BMY7}.
uniprot
proteins