TMEM9
entrez
252839
canonical
uniprot
Q9P0T7
canonical
ensembl
ENSG00000116857
resolver
ensp
ENSP00000356299
resolver
ensp
ENSP00000356301
resolver
ensp
ENSP00000356302
resolver
ensp
ENSP00000356303
resolver
ensp
ENSP00000476893
resolver
ensp
ENSP00000574735
resolver
ensp
ENSP00000574736
resolver
ensp
ENSP00000574737
resolver
enst
ENST00000367330
resolver
enst
ENST00000367332
resolver
enst
ENST00000367333
resolver
enst
ENST00000367334
resolver
enst
ENST00000485839
resolver
enst
ENST00000904676
resolver
enst
ENST00000904677
resolver
enst
ENST00000904678
resolver
genesymbol
TMEM9
resolver
genesymbol_syn
DERP4
resolver
genesymbol_syn
TMEM9A
resolver
hgnc
HGNC:18823
resolver
uniprot
B1ALM5
resolver
uniprot
B1ALM6
resolver
uniprot
B4E1H4
resolver
uniprot
Q96NQ9
resolver
uniprot
Q9BQF5
resolver
uniprot_entry
B1ALM5_HUMAN
resolver
uniprot_entry
B4E1H4_HUMAN
resolver
uniprot_entry
TMEM9_HUMAN
resolver
uniprot_sec
B1ALM6
resolver
uniprot_sec
Q96NQ9
resolver
uniprot_sec
Q9BQF5
resolver
amino_acid_sequence
MKLLSLVAVVGCLLVPPAEANKSSEDIRCKCICPPYRNISGHIYNQNVSQKDCNCLHVVEPMPVPGHDVEAYCLLCECRYEERSTTTIKVIIVIYLSVVGALLLYMAFLMLVDPLIRKPDAYTEQLHNEEENEDARSMAAAAASLGGPRANTVLERVEGAQQRWKLQVQEQRKTVFDRHKMLS
uniprot
proteins
function
FUNCTION: Transmembrane protein that binds to and facilitates the assembly of lysosomal proton-transporting V-type ATPase (v-ATPase), resulting in enhanced lysosomal acidification and trafficking (PubMed:30374053). By bringing the v-ATPase accessory protein ATP6AP2 and the v-ATPase subunit ATP6V0D1 together, allows v-ATPase complex formation and activation (PubMed:30374053). TMEM9-controlled vesicular acidification induces hyperactivation of Wnt/beta-catenin signaling, involved in development, tissue homeostasis and tissue regeneration, through lysosomal degradation of adenomatous polyposis coli/APC (PubMed:30374053, PubMed:32380568). In the liver, involved in hepatic regeneration (PubMed:32380568). {ECO:0000269|PubMed:30374053, ECO:0000269|PubMed:32380568}.
uniprot
proteins
mass_dalton
20574
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:12359240}.
uniprot
proteins
protein_family
TMEM9 family
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12359240
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
30374053
uniprot
proteins
pubmed
32380568
uniprot
proteins
sequence_length
183
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:12359240, ECO:0000305|PubMed:30374053}; Single-pass type I membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:12359240, ECO:0000269|PubMed:30374053}; Single-pass type I membrane protein {ECO:0000255}. Endosome, multivesicular body membrane {ECO:0000269|PubMed:30374053}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 90..110; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins