E2f7
entrez
314818
canonical
uniprot
D4A4D7
canonical
ensembl
ENSRNOG00000026252
resolver
ensp
ENSRNOP00000081093
resolver
enst
ENSRNOT00000104778
resolver
genesymbol
E2f7
resolver
uniprot_entry
E2F7_RAT
resolver
amino_acid_sequence
MEVNCLTLKDLISPRQTRLDFAVEDAETAQKENIFVDRSRMTPKTPMKNEPIDLSKQRIFTPERSPITPVKLVDRQPQVEPWTPTANLKMLISAASPDIRDREKKKELFRPIENKGDAFVNSLQLDVVGDSAVDDYEKRRPSRKQKSLGLLCQKFLARYPSYPLSTEKTTISLDEVAVSLGVERRRIYDIVNVLESLHLVSRVAKNQYGWHGRHSLPKTLRTLQRLGEEQKYEEQMACLQQKELDLMEYRFGERRKDGSPDPRDQHLLDFSESDYPSSSANSRKDKSLRIMSQKFVMLFLVSKTKIVTLDVAAKILIEESQDTPDHSKFKTKVRRLYDIANVLTSLALIKKVHVTEERGRKPAFKWIGPVDFSSIDEELLDVSASVLPELKKETYGQIRVCAKERLARYGSFNTVQTSEKIQRKVNSEPSSPQGGKQGPAYSLEIGSLAAIYRQKVEDSSQGEAFVNKRAAPPASVLDPTLPVDSEYCVKPLAQPVFSVAQTDLQAFSAQNGLNGQVGVPVPSAASDAETLKSALLASQPLVYVPSTSLFMLYGSVQEALSPESRSEEDGSGSDVPADLSLAPTAQKRLCEERNPLEDDEPAVKRQSREFEDSPLSLVMPKKPSNSTDLAFPVTTGNGRATPLEDACVKGQLPAAEDASGRAVPNGFIASECGNPSRNPDTEKSSNDNEITKDPSLLQYLYVQSPAGLNGFNMLLPGGQTPHAVAPSSAAMPSFGVPCMFLPSPGLGPFPVLYSPAIPGPISSAPGTLPNTGPMNFGLSTLASASHLLISPAAMVNPKSSTLPSADPQLRCQPPLNPNPVMPGSHGVIHPESPGYMRHPVSMVKAEQSPAPATPKSIQRRHRETFFKTPGSLGDPAFRRERNQSRNTSSAQRRLEISSSGPD
uniprot
proteins
function
FUNCTION: Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
99029
uniprot
proteins
protein_family
E2F/DP family
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
902
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins