Cnga4
entrez
233649
canonical
uniprot
Q3UW12
canonical
ensembl
ENSMUSG00000030897
resolver
ensp
ENSMUSP00000033187
resolver
ensp
ENSMUSP00000147387
resolver
genesymbol
Cnga4
resolver
uniprot
Q08EL1
resolver
uniprot_entry
CNGA4_MOUSE
resolver
uniprot_sec
Q08EL1
resolver
activity_regulation
ACTIVITY REGULATION: Ca(2+)-calmodulin exerts its inhibitory effect in cAMP sensitivity by binding to IQ-like motif of CNGA4 and preferably binds to the channel in the closed state. Inhibition by PIP3 of the CNG channel probably occurs via CGNA2 binding. {ECO:0000250|UniProtKB:Q64359, ECO:0000250|UniProtKB:Q8IV77}.
uniprot
proteins
amino_acid_sequence
MSQDSKVKTTESTPPAPTKARKWLPVLDPSGDYYYWWLNTMVFPIMYNLIIVVCRACFPDLQHSYLVAWFVLDYTSDLLYLLDIGVRFHTGFLEQGILVVDKSMIASRYVRTWSFLLDLASLVPTDAAYVQLGPHIPTLRLNRFLRVPRLFEAFDRTETRTAYPNAFRIAKLMIYIFVVIHWNSCLYFALSRYLGFGRDAWVYPDPAQPGFERLRRQYLYSFYFSTLILTTVGDTPLPAREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRRLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGREMYIIREGQLAVVADDGVTQYAVLGAGLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQAQAVMEEKGREILLKMNKLDVNAEAAEIALQEATESRLKGLDQQLDDLQTKFARLLAELESSALKIAYRIERLEWQTREWPMPDDMGEADDEAEPGEGTSKDGEEKAGQEGPSGLE
uniprot
proteins
function
FUNCTION: Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants. Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations. Conducts cAMP- and cGMP-gated ion currents, with permeability for monovalent and divalent cations (By similarity) (PubMed:11739959, PubMed:12649326). May conduct nitric oxide-gated Ca(2+) currents relevant to neurons of vomeronasal organ, a system involved in the perception of pheromones (By similarity). {ECO:0000250|UniProtKB:Q64359, ECO:0000269|PubMed:11739959, ECO:0000269|PubMed:12649326}.
uniprot
proteins
mass_dalton
65835
uniprot
proteins
protein_family
CNGA4 subfamily
uniprot
proteins
protein_family
Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family
uniprot
proteins
pubmed
11739959
uniprot
proteins
pubmed
11764791
uniprot
proteins
pubmed
12649326
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
575
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q64359}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 39..60; /note="Helical; Name=S1"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 71..91; /note="Helical; Name=S2"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 117..135; /note="Helical; Name=S3"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 141..159; /note="Helical; Name=S4"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 167..190; /note="Helical; Name=S5"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 214..248; /note="Helical; Name=P-helix"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 249..273; /note="Helical; Name=S6"; /evidence="ECO:0000250|UniProtKB:P29973
uniprot
proteins