Snf8
entrez
27681
canonical
uniprot
Q9CZ28
canonical
ensembl
ENSMUSG00000006058
resolver
ensp
ENSMUSP00000006217
resolver
ensp
ENSMUSP00000103328
resolver
ensp
ENSMUSP00000253078
resolver
enst
ENSMUST00000006217
resolver
enst
ENSMUST00000107700
resolver
genesymbol
Snf8
resolver
genesymbol_syn
D11Moh34
resolver
uniprot
A2A6M1
resolver
uniprot
A2A6M2
resolver
uniprot_entry
A2A6M1_MOUSE
resolver
uniprot_entry
SNF8_MOUSE
resolver
uniprot_sec
A2A6M2
resolver
amino_acid_sequence
MHRRGVGAGAIAKKKLAEAKYKERGTVLAEDQLAQMSKQLDMFKTNLEEFASKHKQEIRKNPEFRVQFQDMCATIGVDPLASGKGFWSEMLGVGDFYYELGVQIIEVCLALKHRNGGLITLEELHQQVLKGRGKFAQDVSQDDLIRAIKKLKALGTGFGIIPVGGTYLIQSVPAELNMDHTVVLQLAEKNGYVTVSEIKTSLKWETERARQVLEHLLKEGLAWLDLQAPGEAHYWLPALFTDLYSQEISAEEAKEAFP
uniprot
proteins
function
FUNCTION: Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs, and plays a role in autophagy. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. The ESCRT-II complex may also play a role in transcription regulation by participating in derepression of transcription by RNA polymerase II, possibly via its interaction with ELL. Required for degradation of both endocytosed EGF and EGFR, but not for the EGFR ligand-mediated internalization. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). {ECO:0000250|UniProtKB:Q5U3V9, ECO:0000250|UniProtKB:Q96H20}.
uniprot
proteins
mass_dalton
28886
uniprot
proteins
protein_family
SNF8 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
258
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome membrane {ECO:0000250}. Nucleus {ECO:0000305}. Late endosome membrane {ECO:0000250}. Note=Recruited to the endosome membrane to participate in vesicle formation. {ECO:0000250}.
uniprot
proteins