PRODH
entrez
5625
canonical
uniprot
O43272
canonical
ensembl
ENSG00000100033
resolver
ensp
ENSP00000334726
resolver
ensp
ENSP00000349577
resolver
ensp
ENSP00000410805
resolver
enst
ENST00000334029
resolver
enst
ENST00000420436
resolver
genesymbol
PRODH
resolver
genesymbol_syn
PIG6
resolver
genesymbol_syn
POX2
resolver
genesymbol_syn
PRODH2
resolver
hgnc
HGNC:9453
resolver
uniprot
A0A087WWM6
resolver
uniprot
A6NF53
resolver
uniprot
E7EQL6
resolver
uniprot
O14680
resolver
uniprot
Q0P507
resolver
uniprot
Q147W8
resolver
uniprot
Q504W1
resolver
uniprot
Q59FI8
resolver
uniprot
Q6NV86
resolver
uniprot
Q9UF13
resolver
uniprot_entry
E7EQL6_HUMAN
resolver
uniprot_entry
PROD_HUMAN
resolver
uniprot_sec
A0A087WWM6
resolver
uniprot_sec
A6NF53
resolver
uniprot_sec
O14680
resolver
uniprot_sec
Q0P507
resolver
uniprot_sec
Q147W8
resolver
uniprot_sec
Q504W1
resolver
uniprot_sec
Q59FI8
resolver
uniprot_sec
Q6NV86
resolver
uniprot_sec
Q9UF13
resolver
amino_acid_sequence
MALRRALPALRPCIPRFVPLSTAPASREQPAAGPAAVPGGGSATAVRPPVPAVDFGNAQEAYRSRRTWELARSLLVLRLCAWPALLARHEQLLYVSRKLLGQRLFNKLMKMTFYGHFVAGEDQESIQPLLRHYRAFGVSAILDYGVEEDLSPEEAEHKEMESCTSAAERDGSGTNKRDKQYQAHWAFGDRRNGVISARTYFYANEAKCDSHMETFLRCIEASGRVSDDGFIAIKLTALGRPQFLLQFSEVLAKWRCFFHQMAVEQGQAGLAAMDTKLEVAVLQESVAKLGIASRAEIEDWFTAETLGVSGTMDLLDWSSLIDSRTKLSKHLVVPNAQTGQLEPLLSRFTEEEELQMTRMLQRMDVLAKKATEMGVRLMVDAEQTYFQPAISRLTLEMQRKFNVEKPLIFNTYQCYLKDAYDNVTLDVELARREGWCFGAKLVRGAYLAQERARAAEIGYEDPINPTYEATNAMYHRCLDYVLEELKHNAKAKVMVASHNEDTVRFALRRMEELGLHPADHRVYFGQLLGMCDQISFPLGQAGYPVYKYVPYGPVMEVLPYLSRRALENSSLMKGTHRERQLLWLELLRRLRTGNLFHRPA
uniprot
proteins
disease_involvement
DISEASE: Hyperprolinemia 1 (HYRPRO1) [MIM:239500]: An inborn error of proline metabolism resulting in elevated levels of proline in the plasma and urine. The disorder is generally benign and most affected individuals are clinically asymptomatic. Some patients, however, have neurologic manifestations, including epilepsy and intellectual disability. Association with certain forms of schizophrenia have been reported. {ECO:0000269|PubMed:11891283, ECO:0000269|PubMed:12217952, ECO:0000269|PubMed:15662599, ECO:0000269|PubMed:17135275}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Schizophrenia 4 (SCZD4) [MIM:600850]: A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. {ECO:0000269|PubMed:11891283}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
1.5.5.2
uniprot
proteins
function
FUNCTION: Converts proline to delta-1-pyrroline-5-carboxylate. {ECO:0000269|PubMed:15662599}.
uniprot
proteins
mass_dalton
68029
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.
uniprot
proteins
protein_family
Proline oxidase family
uniprot
proteins
pubmed
10192398
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
11891283
uniprot
proteins
pubmed
12217952
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15662599
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17135275
uniprot
proteins
pubmed
9305847
uniprot
proteins
pubmed
9385373
uniprot
proteins
sequence_length
600
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix.
uniprot
proteins