RAD51D
entrez
5892
canonical
uniprot
O75771
canonical
ensembl
ENSG00000185379
resolver
ensp
ENSP00000338408
resolver
ensp
ENSP00000338790
resolver
ensp
ENSP00000466399
resolver
genesymbol
RAD51D
resolver
genesymbol_syn
RAD51L3
resolver
hgnc
HGNC:9823
resolver
uniprot
B4DJU7
resolver
uniprot
E1P637
resolver
uniprot
O43537
resolver
uniprot
O60355
resolver
uniprot
O75196
resolver
uniprot
O75847
resolver
uniprot
O75848
resolver
uniprot
O76073
resolver
uniprot
O76085
resolver
uniprot
O94908
resolver
uniprot
Q9UFU5
resolver
uniprot_entry
RA51D_HUMAN
resolver
uniprot_sec
B4DJU7
resolver
uniprot_sec
E1P637
resolver
uniprot_sec
O43537
resolver
uniprot_sec
O60355
resolver
uniprot_sec
O75196
resolver
uniprot_sec
O75847
resolver
uniprot_sec
O75848
resolver
uniprot_sec
O76073
resolver
uniprot_sec
O76085
resolver
uniprot_sec
O94908
resolver
uniprot_sec
Q9UFU5
resolver
amino_acid_sequence
MGVLRVGLCPGLTEEMIQLLRSHRIKTVVDLVSADLEEVAQKCGLSYKALVALRRVLLAQFSAFPVNGADLYEELKTSTAILSTGIGSLDKLLDAGLYTGEVTEIVGGPGSGKTQVCLCMAANVAHGLQQNVLYVDSNGGLTASRLLQLLQAKTQDEEEQAEALRRIQVVHAFDIFQMLDVLQELRGTVAQQVTGSSGTVKVVVVDSVTAVVSPLLGGQQREGLALMMQLARELKTLARDLGMAVVVTNHITRDRDSGRLKPALGRSWSFVPSTRILLDTIEGAGASGGRRMACLAKSSRQPTGFQEMVDIGTWGTSEQSATLQGDQT
uniprot
proteins
disease_involvement
DISEASE: Breast-ovarian cancer, familial, 4 (BROVCA4) [MIM:614291]: A condition associated with familial predisposition to cancer of the breast and ovaries. Characteristic features in affected families are an early age of onset of breast cancer (often before age 50), increased chance of bilateral cancers (cancer that develop in both breasts, or both ovaries, independently), frequent occurrence of breast cancer among men, increased incidence of tumors of other specific organs, such as the prostate. {ECO:0000269|PubMed:21822267}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. Bind to single-stranded DNA (ssDNA) and has DNA-dependent ATPase activity. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. Involved in telomere maintenance. The BCDX2 subcomplex XRCC2:RAD51D can stimulate Holliday junction resolution by BLM. {ECO:0000269|PubMed:10871607, ECO:0000269|PubMed:11751635, ECO:0000269|PubMed:11834724, ECO:0000269|PubMed:11842113, ECO:0000269|PubMed:12975363, ECO:0000269|PubMed:15109494, ECO:0000269|PubMed:23149936}.
uniprot
proteins
mass_dalton
35049
uniprot
proteins
protein_family
RAD51 subfamily
uniprot
proteins
protein_family
RecA family
uniprot
proteins
pubmed
10092526
uniprot
proteins
pubmed
10871607
uniprot
proteins
pubmed
11744692
uniprot
proteins
pubmed
11751635
uniprot
proteins
pubmed
11834724
uniprot
proteins
pubmed
11842112
uniprot
proteins
pubmed
11842113
uniprot
proteins
pubmed
12975363
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14759258
uniprot
proteins
pubmed
15109494
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16710300
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21111057
uniprot
proteins
pubmed
21276791
uniprot
proteins
pubmed
21822267
uniprot
proteins
pubmed
21965664
uniprot
proteins
pubmed
23149936
uniprot
proteins
pubmed
27932480
uniprot
proteins
pubmed
9512535
uniprot
proteins
pubmed
9570954
uniprot
proteins
sequence_length
328
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, telomere.
uniprot
proteins