Dab2
entrez
79128
canonical
uniprot
O88797
canonical
ensembl
ENSRNOG00000028930
resolver
ensembl
ENSRNOG00055006390
resolver
ensembl
ENSRNOG00060023909
resolver
ensembl
ENSRNOG00065021860
resolver
ensp
ENSRNOP00000085091
resolver
enst
ENSRNOT00000096270
resolver
genesymbol
Dab2
resolver
genesymbol_syn
Doc2
resolver
uniprot
A0A8I6A2J0
resolver
uniprot
O55048
resolver
uniprot
O55049
resolver
uniprot
O55050
resolver
uniprot
O55051
resolver
uniprot
O88798
resolver
uniprot
Q4QRA2
resolver
uniprot_entry
A0A8I6A2J0_RAT
resolver
uniprot_entry
DAB2_RAT
resolver
uniprot_sec
O55048
resolver
uniprot_sec
O55049
resolver
uniprot_sec
O55050
resolver
uniprot_sec
O55051
resolver
uniprot_sec
O88798
resolver
uniprot_sec
Q4QRA2
resolver
amino_acid_sequence
MSNEVETSTTNGQPDQQAAPKAPSKKEKKKGSEKTDEYLLARFKGDGVKYKAKLIGIDDVPDARGDKMSQDSMMKLKGMAAAGRSQGQHKQRIWVNISLSGIKIIDEKTGVIEHEHPVNKISFIARDVTDNRAFGYVCGGEGQHQFFAIKTGQQAEPLVVDLKDLFQVIYNVKKKEEEKKKVEEANKAEENGSEALMTLDDQANKLKLGVDQMDLFGDMSTPPDLNNPTESRDILLVDLNSEIDTNQNSLRENPFLTNGVTSCSLPRPKPQASFLPESAFSANLNFFPTPNPDPFRDDPFAQPDQSAPSSFHSLTSADQKKANPGSLSTPQSKGPLNGDTDYFGQQFDQISNRTGKQEAQGGPWPYPSSQTQQAVRTQNGVSEKEQNGFHIKSSPNPFVGSPPKGLSVPNGVKQDLESSVQSSAHDSIAIIPPPQSTKPGRGRRTAKSSANDLLASDIFASEPPGQMSPTGQPAVPQANFMDLFKTSAPAPMGSGPLVGLGTVPVTPPQAGPWTPVVFTPSTTVVPGAIISGQPSGFGQPLVFGTTPAVQVWNQPSSFATAASPPPPAVWCPTTSVAPNTWSSTSPLGNPFQSSNIFPPSTISTQSFPQPMMSSVLVTPPQPPPRNGPLKDTLSDAFTGLDPLGDKEVKEVKEMFKDFQLRQPPLVPSRKGETPSSGTSSAFSSYFNNKVGIPQEHVDHDDFDANQLLNKINEPPKPAPRQGVLSGTKSADNSLENPFSKGFSSTNPSVVSQPASSDAHRSPFGNPFA
uniprot
proteins
function
FUNCTION: Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:12473651, ECO:0000269|PubMed:19000037}.
uniprot
proteins
mass_dalton
82377
uniprot
proteins
mutagenesis
MUTAGEN 393; /note="S->A: Reduces phosphorylation, reduces mitotic membrane displacement; when associated with A-394 and A-401."; /evidence="ECO:0000269|PubMed:21097498"; MUTAGEN 394; /note="S->A: Reduces phosphorylation, reduces mitotic membrane displacement; when associated with A-393 and A-401."; /evidence="ECO:0000269|PubMed:21097498"; MUTAGEN 401; /note="S->A: Reduces phosphorylation, reduces mitotic membrane displacement; when associated with A-393 and A-394."; /evidence="ECO:0000269|PubMed:21097498
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation during mitosis is leading to membrane displacement. There is some ambiguity for the mitotic phosphosite Ser-326/328. {ECO:0000269|PubMed:21097498}.
uniprot
proteins
pubmed
11812785
uniprot
proteins
pubmed
12473651
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19000037
uniprot
proteins
pubmed
19665975
uniprot
proteins
pubmed
21097498
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9681506
uniprot
proteins
sequence_length
768
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Membrane, clathrin-coated pit. Note=Colocalizes with large insert-containing isoforms of MYO6 at clathrin-coated pits/vesicles. During mitosis is progressively displaced from the membrane and translocated to the cytoplasm (By similarity). {ECO:0000250}.
uniprot
proteins