GNPDA1
entrez
10007
canonical
uniprot
P46926
canonical
ensembl
ENSG00000113552
resolver
ensp
ENSP00000311876
resolver
ensp
ENSP00000424275
resolver
ensp
ENSP00000532782
resolver
genesymbol
GNPDA1
resolver
genesymbol_syn
GNPI
resolver
genesymbol_syn
HLN
resolver
genesymbol_syn
KIAA0060
resolver
hgnc
HGNC:4417
resolver
uniprot
B7Z3X4
resolver
uniprot
D3DQE7
resolver
uniprot_entry
GNPI1_HUMAN
resolver
uniprot_sec
B7Z3X4
resolver
uniprot_sec
D3DQE7
resolver
activity_regulation
ACTIVITY REGULATION: Allosterically activated by N-acetylglucosamine-6-phosphate (GlcNAc6P). {ECO:0000269|PubMed:21807125}.
uniprot
proteins
amino_acid_sequence
MKLIILEHYSQASEWAAKYIRNRIIQFNPGPEKYFTLGLPTGSTPLGCYKKLIEYYKNGDLSFKYVKTFNMDEYVGLPRDHPESYHSFMWNNFFKHIDIHPENTHILDGNAVDLQAECDAFEEKIKAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVKTLAMDTILANARFFDGELTKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCDEDATLELKVKTVKYFKGLMLVHNKLVDPLYSIKEKETEKSQSSKKPYSD
uniprot
proteins
ec_number
3.5.99.6
uniprot
proteins
function
FUNCTION: Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis (PubMed:21807125, PubMed:26887390). Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling (PubMed:26887390). Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity). {ECO:0000250|UniProtKB:Q64422, ECO:0000269|PubMed:21807125, ECO:0000269|PubMed:26887390}.
uniprot
proteins
mass_dalton
32669
uniprot
proteins
mutagenesis
MUTAGEN 268..289; /note="Missing: Decreases hexamer stability and catalytic efficiency."; /evidence="ECO:0000269|PubMed:21807125"; MUTAGEN 275..289; /note="Missing: Decreases catalytic efficiency."; /evidence="ECO:0000269|PubMed:21807125
uniprot
proteins
pathway_participation
PATHWAY: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1. {ECO:0000305|PubMed:26887390}.
uniprot
proteins
protein_family
Glucosamine/galactosamine-6-phosphate isomerase family
uniprot
proteins
pubmed
12965206
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21807125
uniprot
proteins
pubmed
26887390
uniprot
proteins
pubmed
7584044
uniprot
proteins
pubmed
9438414
uniprot
proteins
pubmed
9714720
uniprot
proteins
sequence_length
289
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O88958}.
uniprot
proteins