NUAK2
entrez
81788
canonical
uniprot
Q9H093
canonical
ensembl
ENSG00000163545
resolver
ensp
ENSP00000356125
resolver
enst
ENST00000367157
resolver
genesymbol
NUAK2
resolver
genesymbol_syn
OMPHK2
resolver
genesymbol_syn
SNARK
resolver
hgnc
HGNC:29558
resolver
uniprot
B4E0Y5
resolver
uniprot_entry
B4E0Y5_HUMAN
resolver
uniprot_entry
NUAK2_HUMAN
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation on Thr-208. {ECO:0000269|PubMed:14976552}.
uniprot
proteins
amino_acid_sequence
MESLVFARRSGPTPSAAELARPLAEGLIKSPKPLMKKQAVKRHHHKHNLRHRYEFLETLGKGTYGKVKKARESSGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPHIIAIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRVVHRDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEVDSWSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPSDACGLIRWLLMVNPTRRATLEDVASHWWVNWGYATRVGEQEAPHEGGHPGSDSARASMADWLRRSSRPLLENGAKVCSFFKQHAPGGGSTTPGLERQHSLKKSRKENDMAQSLHSDTADDTAHRPGKSNLKLPKGILKKKVSASAEGVQEDPPELSPIPASPGQAAPLLPKKGILKKPRQRESGYYSSPEPSESGELLDAGDVFVSGDPKEQKPPQASGLLLHRKGILKLNGKFSQTALELAAPTTFGSLDELAPPRPLARASRPSGAVSEDSILSSESFDQLDLPERLPEPPLRGCVSVDNLTGLEEPPSEGPGSCLRRWRQDPLGDSCFSLTDCQEVTATYRQALRVCSKLT
uniprot
proteins
disease_involvement
DISEASE: Anencephaly 2 (ANPH2) [MIM:619452]: A form of anencephaly, an extreme neural tube defect resulting in the absence of brain tissues, and death in utero or perinatally. Infants are born with intact spinal cords, cerebellums, and brainstems, but lack formation of neural structures above this level. The skull is only partially formed. ANPH2 features may also include frontonasal dysplasia with midline cleft of the upper lip and alveolar ridge, bifid nose, and clinical anophthalmia. ANPH2 inheritance is autosomal recessive. {ECO:0000269|PubMed:32845958}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway (PubMed:32845958). {ECO:0000269|PubMed:14575707, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15345718, ECO:0000269|PubMed:19927127, ECO:0000269|PubMed:32845958}.
uniprot
proteins
mass_dalton
69612
uniprot
proteins
mutagenesis
MUTAGEN 81; /note="K->R: Loss of autophosphorylation, kinase activity and of anti-apoptotic activity."; /evidence="ECO:0000269|PubMed:15345718"; MUTAGEN 208; /note="T->A: Prevents phosphorylation and activation by STK11/LKB1 complex."; /evidence="ECO:0000269|PubMed:14976552
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Thr-208 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39 (PubMed:14976552). Autophosphorylation is also possible at Thr-208 (PubMed:32845958). {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:32845958}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
SNF1 subfamily
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14575707
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14976552
uniprot
proteins
pubmed
15345718
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19927127
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
32845958
uniprot
proteins
sequence_length
628
uniprot
proteins