Rbpms
entrez
498642
canonical
uniprot
A0A8I6G705
canonical
ensembl
ENSRNOG00000013328
resolver
ensembl
ENSRNOG00055012300
resolver
ensembl
ENSRNOG00060011971
resolver
ensembl
ENSRNOG00065002832
resolver
ensp
ENSRNOP00000017883
resolver
ensp
ENSRNOP00000111391
resolver
genesymbol
Rbpms
resolver
uniprot
A0A8I5ZR01
resolver
uniprot
F1M9Y9
resolver
uniprot_entry
RBPMS_RAT
resolver
uniprot_sec
A0A8I5ZR01
resolver
uniprot_sec
F1M9Y9
resolver
amino_acid_sequence
MNGGGKAEKENTPSEANLQEEEVRTLFVSGLPLDIKPRELYLLFRPFKGYEGSLIKLTSKQPVGFVSFDSRSEAEAAKNALNGIRFDPEIPQTLRLEFAKANTKMAKNKLVGTPNPSTPLPNTVPQFIAREPYELTVPALYPSSPEVWAPYPLYPAELAPALPPPAAFTYPASLHAQMRWLPPSEATSQGWKSRQFC
uniprot
proteins
function
FUNCTION: [Isoform 1]: RNA binding protein that mediates pre-mRNA alternative splicing (AS) regulation (PubMed:31283468, PubMed:37548402). Acts either as activator (FLNB, HSPG2, LIPA1, MYOCD, PTPRF and PPFIBP1) or repressor (TPM1, ACTN1, ITGA7, PIEZO1, LSM14B, MBNL1 and MBML2) of splicing events on specific pre-mRNA targets (PubMed:31283468, PubMed:37548402). Together with RNA binding proteins RBFOX2 and MBNL1/2, activates a splicing program associated with differentiated contractile vascular smooth muscle cells (SMC) by regulating AS of numerous pre-mRNA involved in actin cytoskeleton and focal adhesion machineries, suggesting a role in promoting a cell differentiated state (PubMed:31283468, PubMed:37548402). Binds to introns, exons and 3'-UTR associated with tandem CAC trinucleotide motifs separated by a variable spacer region, at a minimum as a dimer. The minimal length of RNA required for RBPMS-binding tandem CAC motifs is 15 nt, with spacing ranging from 1 to 9 nt. Can also bind to CA dinucleotide repeats (By similarity). Mediates repression of TPM1 exon 3 by binding to CAC tandem repeats in the flanking intronic regions, followed by higher-order oligomerization and heterotypic interactions with other splicing regulators including MBNL1 and RBFOX2, which prevents assembly of ATP-dependent splicing complexes (PubMed:37548402). {ECO:0000250|UniProtKB:Q93062, ECO:0000269|PubMed:31283468, ECO:0000269|PubMed:37548402}.; FUNCTION: [Isoform 2]: Acts as a regulator of pre-mRNA alternative splicing (AS) (PubMed:31283468). Binds mRNA (By similarity). Regulates AS of ACTN1, FLNB, although with lower efficiency than isoform 1 (PubMed:31283468). Acts as coactivator of SMAD transcriptional activity in a TGFB1-dependent manner, possibly through increased phosphorylation of SMAD2 and SMAD3 at the C-terminal SSXS regions and promotion of the nuclear accumulation of SMAD proteins (By similarity). {ECO:0000250|UniProtKB:Q93062, ECO:0000269|PubMed:31283468}.
uniprot
proteins
mass_dalton
21816
uniprot
proteins
mutagenesis
MUTAGEN 100; /note="K->E: Loss of interaction with MATR3, RBM4, RBM14, RBFOX2, ESRP2 and MBNL1. Partial loss of interaction with RBM47."; /evidence="ECO:0000269|PubMed:37548402"; MUTAGEN 178..197; /note="Missing: Loss of TMP1 exon 3 splicing repressor activity. Loss of higher-order oligomers formation. Loss of interaction with MATR3, RBM4, RBM14, RBM47, RBFOX2, ESRP2 and MBNL1."; /evidence="ECO:0000269|PubMed:37548402
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
31283468
uniprot
proteins
pubmed
37548402
uniprot
proteins
sequence_length
197
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q93062}. Cytoplasm {ECO:0000250|UniProtKB:Q93062}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:Q93062}. Cytoplasm, P-body {ECO:0000250|UniProtKB:Q93062}.
uniprot
proteins