Dhodh
entrez
65156
canonical
uniprot
Q63707
canonical
ensembl
ENSRNOG00000015063
resolver
ensembl
ENSRNOG00055021002
resolver
ensembl
ENSRNOG00060011765
resolver
ensembl
ENSRNOG00065011307
resolver
ensp
ENSRNOP00000091052
resolver
ensp
ENSRNOP00055029266
resolver
ensp
ENSRNOP00060015753
resolver
ensp
ENSRNOP00065014120
resolver
enst
ENSRNOT00000102191
resolver
enst
ENSRNOT00055036054
resolver
enst
ENSRNOT00060020081
resolver
enst
ENSRNOT00065018464
resolver
genesymbol
Dhodh
resolver
uniprot_entry
PYRD_RAT
resolver
amino_acid_sequence
MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVRVTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSVTPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGINLGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQERDALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIFLGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR
uniprot
proteins
ec_number
1.3.5.2
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway. {ECO:0000250|UniProtKB:Q02127}.
uniprot
proteins
mass_dalton
42663
uniprot
proteins
pathway_participation
PATHWAY: Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (quinone route): step 1/1.
uniprot
proteins
post_translational_modification
PTM: The uncleaved transit peptide is required for mitochondrial targeting and proper membrane integration.
uniprot
proteins
protein_family
Dihydroorotate dehydrogenase family
uniprot
proteins
protein_family
Type 2 subfamily
uniprot
proteins
pubmed
10727948
uniprot
proteins
pubmed
15044733
uniprot
proteins
pubmed
7660999
uniprot
proteins
sequence_length
395
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:10727948}; Single-pass membrane protein {ECO:0000269|PubMed:10727948}.
uniprot
proteins
transmembrane_region
TRANSMEM 11..30; /note="Helical
uniprot
proteins