FAF2
entrez
23197
canonical
uniprot
Q96CS3
canonical
ensembl
ENSG00000113194
resolver
ensp
ENSP00000261942
resolver
ensp
ENSP00000532073
resolver
enst
ENST00000261942
resolver
genesymbol
FAF2
resolver
genesymbol_syn
ETEA
resolver
genesymbol_syn
KIAA0887
resolver
genesymbol_syn
UBXD8
resolver
genesymbol_syn
UBXN3B
resolver
hgnc
HGNC:24666
resolver
uniprot
O94963
resolver
uniprot
Q8IUF2
resolver
uniprot
Q9BRP2
resolver
uniprot
Q9BVM7
resolver
uniprot_entry
FAF2_HUMAN
resolver
uniprot_sec
O94963
resolver
uniprot_sec
Q8IUF2
resolver
uniprot_sec
Q9BRP2
resolver
uniprot_sec
Q9BVM7
resolver
amino_acid_sequence
MAAPEERDLTQEQTEKLLQFQDLTGIESMDQCRHTLEQHNWNIEAAVQDRLNEQEGVPSVFNPPPSRPLQVNTADHRIYSYVVSRPQPRGLLGWGYYLIMLPFRFTYYTILDIFRFALRFIRPDPRSRVTDPVGDIVSFMHSFEEKYGRAHPVFYQGTYSQALNDAKRELRFLLVYLHGDDHQDSDEFCRNTLCAPEVISLINTRMLFWACSTNKPEGYRVSQALRENTYPFLAMIMLKDRRMTVVGRLEGLIQPDDLINQLTFIMDANQTYLVSERLEREERNQTQVLRQQQDEAYLASLRADQEKERKKREERERKRRKEEEVQQQKLAEERRRQNLQEEKERKLECLPPEPSPDDPESVKIIFKLPNDSRVERRFHFSQSLTVIHDFLFSLKESPEKFQIEANFPRRVLPCIPSEEWPNPPTLQEAGLSHTEVLFVQDLTDE
uniprot
proteins
function
FUNCTION: Plays an important role in endoplasmic reticulum-associated degradation (ERAD) that mediates ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:18711132, PubMed:24215460). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). Recruits ATPase VCP to lipid droplets and also binds to phospholipase PNPLA2/ATGL, inhibiting PNPLA2 activity by promoting its dissociation from its ABHD5/CGI-58 activator (PubMed:23297223). This inhibits PNPLA2-mediated triacylglycerol hydrolysis and leads to inhibition of lipid droplet degradation (PubMed:23297223). Involved in stress granule disassembly: associates with ubiquitinated G3BP1 in response to heat shock, thereby promoting interaction between ubiquitinated G3BP1 and VCP, followed by G3BP1 extraction from stress granules and stress granule disassembly (PubMed:34739333). {ECO:0000269|PubMed:18711132, ECO:0000269|PubMed:23297223, ECO:0000269|PubMed:24215460, ECO:0000269|PubMed:26692333, ECO:0000269|PubMed:34739333}.
uniprot
proteins
mass_dalton
52623
uniprot
proteins
pubmed
10048485
uniprot
proteins
pubmed
12372427
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18711132
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19773358
uniprot
proteins
pubmed
19818707
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23297223
uniprot
proteins
pubmed
24160817
uniprot
proteins
pubmed
24215460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26692333
uniprot
proteins
pubmed
31073040
uniprot
proteins
pubmed
34739333
uniprot
proteins
sequence_length
445
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12372427}. Lipid droplet {ECO:0000269|PubMed:19773358, ECO:0000269|PubMed:23297223}. Endoplasmic reticulum {ECO:0000269|PubMed:18711132, ECO:0000269|PubMed:23297223, ECO:0000269|PubMed:34739333}.
uniprot
proteins