Adcyap1
entrez
11516
canonical
uniprot
O70176
canonical
ensembl
ENSMUSG00000024256
resolver
ensp
ENSMUSP00000067057
resolver
ensp
ENSMUSP00000157279
resolver
ensp
ENSMUSP00000279092
resolver
enst
ENSMUST00000064775
resolver
enst
ENSMUST00000234081
resolver
genesymbol
Adcyap1
resolver
genesymbol_syn
Pacap
resolver
uniprot
Q3UYH8
resolver
uniprot
Q8BJT8
resolver
uniprot_entry
PACA_MOUSE
resolver
uniprot_entry
Q3UYH8_MOUSE
resolver
uniprot_entry
Q8BJT8_MOUSE
resolver
amino_acid_sequence
MTMCSGARLALLVYGIIMHSSVSCSPAAGLSFPGIRPEDEAYDQDGNPLQDFYDWDPPGVGSPASALRDAYALYYPADRRDVAHEILNEAYRKVLDQLSARKYLQSVVARGAGENLGGSAVDDPAPLTKRHSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNKGRRIAYL
uniprot
proteins
function
FUNCTION: PACAP is a neuropeptide involved in diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VIPR1), VIP receptor 2 (VIPR2), and PACAP type I receptor (ADCYAP1R1) (By similarity). Exerts neuroprotective and general cytoprotective effects due to anti-apoptotic, anti-inflammatory, and antioxidant actions (PubMed:18055122). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (By similarity). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (PubMed:23913443). PACAP exists in two bioactive forms from proteolysis of the same precursor protein, PACAP27 and PACAP38, which differ by eleven amino acid residues in the C-terminus (By similarity). {ECO:0000250|UniProtKB:P13589, ECO:0000250|UniProtKB:P18509, ECO:0000269|PubMed:18055122, ECO:0000269|PubMed:23913443}.
uniprot
proteins
mass_dalton
19381
uniprot
proteins
protein_family
Glucagon family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18055122
uniprot
proteins
pubmed
23913443
uniprot
proteins
pubmed
9573339
uniprot
proteins
sequence_length
175
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins