FAM83G
entrez
644815
canonical
uniprot
A6ND36
canonical
ensembl
ENSG00000188522
resolver
ensp
ENSP00000373647
resolver
genesymbol
FAM83G
resolver
genesymbol_syn
PAWS1
resolver
hgnc
HGNC:32554
resolver
uniprot
Q3KQZ4
resolver
uniprot
Q6ZW60
resolver
uniprot_entry
FA83G_HUMAN
resolver
uniprot_sec
Q3KQZ4
resolver
uniprot_sec
Q6ZW60
resolver
amino_acid_sequence
MAFSQVQCLDDNHVNWRSSESKPEFFYSEEQRLALEALVARGRDAFYEVLKRENIRDFLSELELKRILETIEVYDPGSEDPRGTGPSQGPEDNGVGDGEEASGADGVPIEAEPLPSLEYWPQKSDRSIPQLDLGWPDTIAYRGVTRASVYMQPPIDGQAHIKEVVRKMISQAQKVIAVVMDMFTDVDIFKDLLDAGFKRKVAVYIIVDESNVKYFLHMCERACMHLGHLKNLRVRSSGGTEFFTRSATKFKGALAQKFMFVDGDRAVCGSYSFTWSAARTDRNVISVLSGQVVEMFDRQFQELYLMSHSVSLKGIPMEKEPEPEPIVLPSVVPLVPAGTVAKKLVNPKYALVKAKSVDEIAKISSEKQEAKKPLGLKGPALAEHPGELPELLPPIHPGLLHLERANMFEYLPTWVEPDPEPGSDILGYINIIDPNIWNPQPSQMNRIKIRDTSQASAQHQLWKQSQDSRPRPEPCPPPEPSAPQDGVPAENGLPQGDPEPLPPVPKPRTVPVADVLARDSSDIGWVLELPKEEAPQNGTDHRLPRMAGPGHAPLQRQLSVTQDDPESLGVGLPNGLDGVEEEDDDDYVTLSDQDSHSGSSGRGPGPRRPSVASSVSEEYFEVREHSVPLRRRHSEQVANGPTPPPRRQLSAPHITRGTFVGPQGGSPWAQSRGREEADALKRMQAQRSTDKEAQGQQFHHHRVPASGTRDKDGFPGPPRYRSAADSVQSSTRNAGPAMAGPHHWQAKGGQVPRLLPDPGSPRLAQNARPMTDGRATEEHPSPFGIPYSKLSQSKHLKARTGGSQWASSDSKRRAQAPRDRKDP
uniprot
proteins
function
FUNCTION: Substrate for type I BMP receptor kinase involved in regulation of some target genes of the BMP signaling pathway. Also regulates the expression of several non-BMP target genes, suggesting a role in other signaling pathways. {ECO:0000269|PubMed:24554596}.
uniprot
proteins
mass_dalton
90835
uniprot
proteins
mutagenesis
MUTAGEN 296; /note="F->A: Loss of interaction with CSNK1A1. Loss of interaction with CSNK1A1; when associated with A-300."; /evidence="ECO:0000269|PubMed:29789297"; MUTAGEN 300; /note="F->A: No effect on interaction with CSNK1A1. Loss of interaction with CSNK1A1; when associated with A-296."; /evidence="ECO:0000269|PubMed:29789297"; MUTAGEN 610; /note="S->A: Completely abolishes phosphorylation by ALK3 in vitro. NEDD9 and ASNS activation in response to BMPs is abolished."; /evidence="ECO:0000269|PubMed:24554596
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in vitro by CSNK1A1. {ECO:0000269|PubMed:29789297}.; PTM: BMP signaling induces the phosphorylation by BMPR1A at Ser-610, Ser-614 and Ser-616. Phosphorylation at Ser-610 is necessary for the activation of SMAD4-independent BMP target genes such as NEDD9 and ASNS. {ECO:0000269|PubMed:24554596}.
uniprot
proteins
protein_family
SACK1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24554596
uniprot
proteins
pubmed
26477546
uniprot
proteins
pubmed
29789297
uniprot
proteins
sequence_length
823
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:24554596, ECO:0000269|PubMed:29789297}. Nucleus {ECO:0000269|PubMed:24554596}. Note=Detected predominantly in the cytosol. Upon BMP stimulation, a small portion localizes the nucleus. {ECO:0000269|PubMed:24554596}.
uniprot
proteins