CASP5
entrez
838
canonical
uniprot
P51878
canonical
ensembl
ENSG00000137757
resolver
ensp
ENSP00000260315
resolver
ensp
ENSP00000376849
resolver
ensp
ENSP00000388365
resolver
ensp
ENSP00000398130
resolver
genesymbol
CASP5
resolver
genesymbol_syn
ICH3
resolver
hgnc
HGNC:1506
resolver
uniprot
B4DKP5
resolver
uniprot
Q0QVY7
resolver
uniprot
Q0QVY8
resolver
uniprot
Q0QVZ0
resolver
uniprot
Q0QVZ1
resolver
uniprot
Q0QVZ2
resolver
uniprot
Q14DD6
resolver
uniprot
Q1HBJ3
resolver
uniprot
Q6DJV7
resolver
uniprot_entry
CASP5_HUMAN
resolver
uniprot_sec
B4DKP5
resolver
uniprot_sec
Q0QVY7
resolver
uniprot_sec
Q0QVY8
resolver
uniprot_sec
Q0QVZ0
resolver
uniprot_sec
Q0QVZ1
resolver
uniprot_sec
Q0QVZ2
resolver
uniprot_sec
Q14DD6
resolver
uniprot_sec
Q1HBJ3
resolver
uniprot_sec
Q6DJV7
resolver
amino_acid_sequence
MAEDSGKKKRRKNFEAMFKGILQSGLDNFVINHMLKNNVAGQTSIQTLVPNTDQKSTSVKKDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLRKNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN
uniprot
proteins
ec_number
3.4.22.58
uniprot
proteins
function
FUNCTION: Thiol protease that acts as a mediator of programmed cell death (PubMed:28314590, PubMed:29898893). Initiates pyroptosis, a programmed lytic cell death pathway through cleavage of Gasdermin-D (GSDMD): cleavage releases the N-terminal gasdermin moiety (Gasdermin-D, N-terminal) that binds to membranes and forms pores, triggering pyroptosis (PubMed:29898893). Also mediates cleavage and maturation of IL18 (PubMed:37993714). Cleavage of GSDMD and IL18 is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP4 (PubMed:37993714). During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation (PubMed:28314590). {ECO:0000269|PubMed:28314590, ECO:0000269|PubMed:29898893, ECO:0000269|PubMed:37993714}.
uniprot
proteins
mass_dalton
49736
uniprot
proteins
mutagenesis
MUTAGEN 315; /note="C->A: Abolishes protease activity."; /evidence="ECO:0000269|PubMed:28314590"; MUTAGEN 324; /note="W->L: Abolished ability to cleave IL18."; /evidence="ECO:0000269|PubMed:37993714"; MUTAGEN 348..350; /note="VCK->NCA: Abolished ability to cleave IL18."; /evidence="ECO:0000269|PubMed:37993714
uniprot
proteins
post_translational_modification
PTM: The two subunits are derived from the precursor sequence by an autocatalytic mechanism. {ECO:0000250|UniProtKB:P29466}.
uniprot
proteins
protein_family
Peptidase C14A family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16893518
uniprot
proteins
pubmed
17431422
uniprot
proteins
pubmed
28314590
uniprot
proteins
pubmed
29898893
uniprot
proteins
pubmed
30692621
uniprot
proteins
pubmed
37993714
uniprot
proteins
pubmed
7797592
uniprot
proteins
pubmed
8617266
uniprot
proteins
sequence_length
434
uniprot
proteins