Slc26a9
entrez
320718
canonical
uniprot
Q8BU91
canonical
ensembl
ENSMUSG00000042268
resolver
ensp
ENSMUSP00000036916
resolver
enst
ENSMUST00000049027
resolver
genesymbol
Slc26a9
resolver
uniprot
A0A0R4J0F7
resolver
uniprot
Q8BVC3
resolver
uniprot_entry
A0A0R4J0F7_MOUSE
resolver
uniprot_entry
S26A9_MOUSE
resolver
uniprot_sec
Q8BVC3
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by ammonium and thiosulfate. {ECO:0000269|PubMed:15800055}.
uniprot
proteins
amino_acid_sequence
MNQPRPRYVVDRAAYSLSLFDDEFEKKDRAYPVGEKLRNTFRCSSAKFKAFVFGLLPVLSWLPKYKIKDYIIPDLLGGLSGGCIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGIHQMVPGTFAVISILVGNICLQLAPESKFQIFNNVTNETYVDTAAMEAERLHVSATLACLTAVIQMALGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFTFIDICKNLPHTNIASLIFALVSGVFLVLVKELNARYMHKIHFPIPTEMIVVVVATAISGSCKMPKKYHMQIVGEIRQGFPTPVAPMVSQWKGMVGTAFSLAIVGYVINLAMGRTLASKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITMLVLGSYLYPLPKAVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCVWVVSFLSSFFLSLPYGVAVGVAFSILVVIFQTQFRNGSTLAQVMDTDIYVNPKTYNRAQEIAGVKIVTYCSPLYLANSEIFRQKVIAKTGMDPQKVLLAKQKYLRKQEKRTAIPTQQRKSLFMKTKTVSLQELQQDFESAPSTDPNNNQAPAAEAHISYITFSPDASTAAACELPASTRSPQEASDTLASVPPFVTFHTLILDMSGVSFVDLMGIKALAKLSSTYEKIGVQIFLVNIHAQVYNDISHGGVFEDGCVQRSHVFPSIHDAVLFAQANAREAPDRNFHGAPGDTEFSLYDSEEEGPSYWDLEQEMFGTMFHTETLTAL
uniprot
proteins
function
FUNCTION: Ion transporter that can act both as an ion channel and anion exchanger (PubMed:15800055, PubMed:17120765, PubMed:31339488). Mainly acts as a chloride channel, which mediate uncoupled chloride anion transport in an alternate-access mechanism where a saturable binding site is alternately exposed to either one or the other side of the membrane (PubMed:31339488). Also acts as a DIDS- and thiosulfate- sensitive anion exchanger the exchange of chloride for bicarbonate ions across the cell membrane (PubMed:15800055). {ECO:0000269|PubMed:15800055, ECO:0000269|PubMed:17120765, ECO:0000269|PubMed:31339488}.
uniprot
proteins
mass_dalton
86852
uniprot
proteins
mutagenesis
MUTAGEN 88; /note="Q->A,E: Alters chloride anion transport behavior."; /evidence="ECO:0000269|PubMed:31339488"; MUTAGEN 128; /note="F->A: Alters chloride anion transport behavior."; /evidence="ECO:0000269|PubMed:31339488"; MUTAGEN 205; /note="R->E: Has very little effect on anion transport."; /evidence="ECO:0000269|PubMed:31339488"; MUTAGEN 270; /note="K->E: Impairs outward anion transport properties."; /evidence="ECO:0000269|PubMed:31339488"; MUTAGEN 358; /note="K->E: Has very little effect on anion transport."; /evidence="ECO:0000269|PubMed:31339488"; MUTAGEN 392; /note="S->A: Alters chloride anion transport behavior."; /evidence="ECO:0000269|PubMed:31339488"; MUTAGEN 443; /note="K->E: Impairs outward anion transport properties."; /evidence="ECO:0000269|PubMed:31339488
uniprot
proteins
protein_family
SLC26A/SulP transporter (TC 2.A.53) family
uniprot
proteins
pubmed
15800055
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17120765
uniprot
proteins
pubmed
31339488
uniprot
proteins
sequence_length
790
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:31339488}; Multi-pass membrane protein {ECO:0000269|PubMed:31339488}. Endomembrane system {ECO:0000250|UniProtKB:Q7LBE3}; Multi-pass membrane protein {ECO:0000269|PubMed:31339488}. Note=Localization to the cell membrane is inhibited by WNK kinases (WNK1, WNK2, WNK3 or WNK4) in a kinase-independent mechanism. {ECO:0000250|UniProtKB:Q7LBE3}.
uniprot
proteins
transmembrane_region
TRANSMEM 71..96; /note="Helical"; /evidence="ECO:0000269|PubMed:31339488"; TRANSMEM 101..109; /note="Helical"; /evidence="ECO:0000269|PubMed:31339488"; TRANSMEM 130..142; /note="Helical"; /evidence="ECO:0000269|PubMed:31339488"; TRANSMEM 163..191; /note="Helical"; /evidence="ECO:0000269|PubMed:31339488"; TRANSMEM 202..224; /note="Helical"; /evidence="ECO:0000269|PubMed:31339488"; TRANSMEM 255..275; /note="Helical"; /evidence="ECO:0000269|PubMed:31339488"; TRANSMEM 287..299; /note="Helical"; /evidence="ECO:0000269|PubMed:31339488"; TRANSMEM 335..358; /note="Helical"; /evidence="ECO:0000269|PubMed:31339488"; TRANSMEM 366..379; /note="Helical"; /evidence="ECO:0000269|PubMed:31339488"; TRANSMEM 391..400; /note="Helical"; /evidence="ECO:0000269|PubMed:31339488"; TRANSMEM 406..419; /note="Helical"; /evidence="ECO:0000269|PubMed:31339488"; TRANSMEM 432..457; /note="Helical"; /evidence="ECO:0000269|PubMed:31339488"; TRANSMEM 462..476; /note="Helical"; /evidence="ECO:0000269|PubMed:31339488"; TRANSMEM 480..498; /note="Helical"; /evidence="ECO:0000269|PubMed:31339488
uniprot
proteins