Psd
entrez
73728
canonical
uniprot
Q5DTT2
canonical
ensembl
ENSMUSG00000037126
resolver
ensp
ENSMUSP00000039728
resolver
ensp
ENSMUSP00000093729
resolver
ensp
ENSMUSP00000152942
resolver
ensp
ENSMUSP00000153381
resolver
ensp
ENSMUSP00000204195
resolver
ensp
ENSMUSP00000204196
resolver
ensp
ENSMUSP00000204197
resolver
ensp
ENSMUSP00000204200
resolver
ensp
ENSMUSP00000204203
resolver
ensp
ENSMUSP00000204205
resolver
genesymbol
Psd
resolver
genesymbol_syn
Efa6a
resolver
genesymbol_syn
Kiaa2011
resolver
genesymbol_syn
Psd1
resolver
uniprot
B2RS07
resolver
uniprot
B7ZNN7
resolver
uniprot
Q3TY69
resolver
uniprot
Q6PE10
resolver
uniprot_entry
PSD1_MOUSE
resolver
uniprot_sec
B2RS07
resolver
uniprot_sec
B7ZNN7
resolver
uniprot_sec
Q3TY69
resolver
uniprot_sec
Q6PE10
resolver
amino_acid_sequence
MAQGAMRFCSEGDCAISPPRCPRRWLPEGPVPQSPPASMYGSTGSLIRRVVGPGPRGRDLGRVTAPCTPLRAPPSPHIAPSPWGPSSPTGQPPPGAQSSVVIFRFVEKASVRPLNGLPASGGLSRSWDLGGISAPRPTPALGPGCNRKLRLEASTSDPLPAGGGSVLPGSRDPSRGPLVPPQIGADGLYSSLPNGLGGTPEHLAMHFRGPADTGFLNQGDTWSSPREVSSHAQRIARAKWEFFYGSLDAPSSGAKPPEQVLPSRGVGSKQGSGVAVGRAAKYSETDLDKVPLRCYRETDIDEVLAEREEADSAIESQPSSEGPHGTAQPPASRPSPCPGPSSSLGSGNEDDEAGGEEDVDDEVFEASEGARPGDHMPHSGLLKSPVPFLLGTSPSADGPDSFSCVFEAILESHRAKGTSYSSLASLEALASPGPTQSPFFTFEMPPQPPAPRPDPPAPAPLAPLEPDSGTSSAADGPWTQRREVEESDAGATLAPRKELPSPSHSEDSFGLGAAPLGSEPPLSQLVSDSDSELDSTERLALGSTDTLSNGQKADLEAAQRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELALMGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGHNIGKRMTCGDFIGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDEEELRRSLSELADPNPKVIKRVSGGSGSSSSPFLDLTPEPGAAVYKHGALVRKVHADPDCRKTPRGKRGWKSFHGILKGMILYLQKEEYQPGKALSEAELKNAISIHHALATRASDYSKRPHVFYLRTADWRVFLFQAPSLEQMQSWITRINVVAAMFSAPPFPAAVSSQKKFSRPLLPSAATRLSQEEQVRTHEAKLKAMASELREHRAAHLGKKARGKEADEQRQKEAYLEFEKSRYGTYAALLRVKMKAASEELDTIEAALAQAGSTEDGCPPPHSSPSLRPKPTSQPRAQRPGSETRAGAGSTRPKP
uniprot
proteins
function
FUNCTION: Guanine nucleotide exchange factor for ARF6 (By similarity). Isoform 2 and isoform 3 induce cytoskeletal remodeling, but lead to distinct morphological changes in HeLa cells: isoform 2 induces cell elongation and formation of actin-rich protrusions, whereas isoform 3 promotes the formation of membrane ruffles and loss of stress fibers (PubMed:19494129). {ECO:0000250|UniProtKB:A5PKW4, ECO:0000269|PubMed:19494129}.
uniprot
proteins
mass_dalton
109687
uniprot
proteins
mutagenesis
MUTAGEN 621; /note="E->K: Significantly impaired guanine nucleotide exchange factor activity on ARF6 in PC12 cells."; /evidence="ECO:0000269|PubMed:19494129
uniprot
proteins
protein_family
PSD family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15540117
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17298598
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19494129
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1024
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:15540117, ECO:0000269|PubMed:17298598}. Cell projection, ruffle {ECO:0000269|PubMed:15540117, ECO:0000269|PubMed:17298598}. Note=Colocalizes with ACTN1 in membrane ruffles and central reticular structures. {ECO:0000269|PubMed:15540117, ECO:0000269|PubMed:17298598}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:19494129}. Cell projection {ECO:0000269|PubMed:19494129}. Note=Accumulates in microvilli-like protrusions. {ECO:0000269|PubMed:19494129}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000269|PubMed:15540117, ECO:0000269|PubMed:19494129}. Cell projection, ruffle {ECO:0000269|PubMed:15540117, ECO:0000269|PubMed:19494129}. Note=Colocalizes with F-actin in membrane ruffles. {ECO:0000269|PubMed:15540117, ECO:0000269|PubMed:19494129}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:A5PKW4}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:A5PKW4}. Cleavage furrow {ECO:0000250|UniProtKB:A5PKW4}. Note=Distributed uniformly on the plasma membrane, as well as throughout the cytoplasm during metaphase. Subsequently concentrated at patches in the equatorial region at the onset of cytokinesis, and becomes distributed in the equatorial region concurrent with cleavage furrow ingression. In later cytokinesis phases, fades away from the cleavage furrow and becomes uniformly distributed throughout the plasma membrane. {ECO:0000250|UniProtKB:A5PKW4}.
uniprot
proteins