Tia1
entrez
21841
canonical
uniprot
P52912
canonical
ensembl
ENSMUSG00000071337
resolver
ensp
ENSMUSP00000093424
resolver
ensp
ENSMUSP00000093425
resolver
ensp
ENSMUSP00000109342
resolver
ensp
ENSMUSP00000118558
resolver
ensp
ENSMUSP00000192418
resolver
ensp
ENSMUSP00000326845
resolver
enst
ENSMUST00000095752
resolver
enst
ENSMUST00000095753
resolver
enst
ENSMUST00000113713
resolver
enst
ENSMUST00000130967
resolver
genesymbol
Tia1
resolver
genesymbol_syn
Tia
resolver
uniprot
F6VPY6
resolver
uniprot
F6VQE4
resolver
uniprot
G5E8L2
resolver
uniprot
Q564E7
resolver
uniprot
Q80ZW7
resolver
uniprot
Q8CII5
resolver
uniprot_entry
F6VPY6_MOUSE
resolver
uniprot_entry
F6VQE4_MOUSE
resolver
uniprot_entry
G5E8L2_MOUSE
resolver
uniprot_entry
Q564E7_MOUSE
resolver
uniprot_entry
Q80ZW7_MOUSE
resolver
uniprot_entry
Q8CII5_MOUSE
resolver
uniprot_entry
TIA1_MOUSE
resolver
amino_acid_sequence
MEDEMPKTLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDTAGNDPYCFVEFHEHRHAAAALAAMNGRKIMGKEVKVNWATTPSSQKKDTSSSTVVSTQRSQDHFHVFVGDLSPEITTEDIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYESNTKQLSYDEVVSQSSPNNCTVYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFPDKGYSFVRFSSHESAAHAIVSVNGTTIEGHVVKCYWGKETLDMINPVQQQNQIGYPPTYGQWGQWYGNAQQIGQYVPNGWQVPAYGVYGQPWSQQGFNQTQSSAPWMGPNYSVPPPQGQNGSMLPSQPAGYRVAGYETQ
uniprot
proteins
function
FUNCTION: RNA-binding protein involved in the regulation of alternative pre-RNA splicing and mRNA translation by binding to uridine-rich (U-rich) RNA sequences (PubMed:10938105, PubMed:16227602). Binds to U-rich sequences immediately downstream from a 5' splice sites in a uridine-rich small nuclear ribonucleoprotein (U snRNP)-dependent fashion, thereby modulating alternative pre-RNA splicing (PubMed:10938105). Preferably binds to the U-rich IAS1 sequence in a U1 snRNP-dependent manner; this binding is optimal if a 5' splice site is adjacent to IAS1 (PubMed:10938105). Activates the use of heterologous 5' splice sites; the activation depends on the intron sequence downstream from the 5' splice site, with a preference for a downstream U-rich sequence (PubMed:10938105). By interacting with SNRPC/U1-C, promotes recruitment and binding of spliceosomal U1 snRNP to 5' splice sites followed by U-rich sequences, thereby facilitating atypical 5' splice site recognition by U1 snRNP (By similarity). Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIAR mRNA (PubMed:11514562). Acts as a modulator of alternative splicing for the apoptotic FAS receptor, thereby promoting apoptosis (By similarity). Binds to the 5' splice site region of FAS intron 5 to promote accumulation of transcripts that include exon 6 at the expense of transcripts in which exon 6 is skipped, thereby leading to the transcription of a membrane-bound apoptotic FAS receptor, which promotes apoptosis (By similarity). Binds to a conserved AU-rich cis element in COL2A1 intron 2 and modulates alternative splicing of COL2A1 exon 2 (By similarity). Also binds to the equivalent AT-rich element in COL2A1 genomic DNA, and may thereby be involved in the regulation of transcription (By similarity). Involved in the repression of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs), including target ARE-bearing mRNAs encoding TNF and PTGS2 (PubMed:10921895, PubMed:16227602). Also participates in the cellular response to environmental stress, by acting downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SGs), leading to stress-induced translational arrest (By similarity). Formation and recruitment to SGs is regulated by Zn(2+) (PubMed:29298433). Possesses nucleolytic activity against cytotoxic lymphocyte target cells (By similarity). {ECO:0000250|UniProtKB:P31483, ECO:0000269|PubMed:10921895, ECO:0000269|PubMed:10938105, ECO:0000269|PubMed:11514562, ECO:0000269|PubMed:16227602, ECO:0000269|PubMed:29298433}.
uniprot
proteins
mass_dalton
42800
uniprot
proteins
post_translational_modification
PTM: Phosphorylatedby FASTK; phosphorylation occurs after FAS ligation in FAS-mediated apoptosis and before DNA fragmentation. {ECO:0000250|UniProtKB:P31483}.
uniprot
proteins
pubmed
10921895
uniprot
proteins
pubmed
10938105
uniprot
proteins
pubmed
11514562
uniprot
proteins
pubmed
16227602
uniprot
proteins
pubmed
16278295
uniprot
proteins
pubmed
18500819
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29298433
uniprot
proteins
pubmed
8759725
uniprot
proteins
pubmed
8871565
uniprot
proteins
sequence_length
386
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16278295}. Cytoplasm {ECO:0000269|PubMed:16278295}. Cytoplasm, Stress granule {ECO:0000269|PubMed:29298433}. Note=Accumulates in cytoplasmic stress granules (SG) following cellular damage (PubMed:29298433). Recruitment to SG is induced by Zn(2+) (PubMed:29298433). {ECO:0000269|PubMed:29298433}.
uniprot
proteins