IL19
entrez
29949
canonical
uniprot
Q9UHD0
canonical
ensembl
ENSG00000142224
resolver
ensp
ENSP00000270218
resolver
ensp
ENSP00000343000
resolver
ensp
ENSP00000499459
resolver
ensp
ENSP00000499487
resolver
genesymbol
IL19
resolver
genesymbol_syn
ZMDA1
resolver
hgnc
HGNC:5990
resolver
uniprot
B6VEV9
resolver
uniprot
Q5VUT3
resolver
uniprot
Q96QR4
resolver
uniprot
Q9NUA0
resolver
uniprot_entry
IL19_HUMAN
resolver
uniprot_sec
B6VEV9
resolver
uniprot_sec
Q5VUT3
resolver
uniprot_sec
Q96QR4
resolver
uniprot_sec
Q9NUA0
resolver
amino_acid_sequence
MKLQCVSLWLLGTILILCSVDNHGLRRCLISTDMHHIEESFQEIKRAIQAKDTFPNVTILSTLETLQIIKPLDVCCVTKNLLAFYVDRVFKDHQEPNPKILRKISSIANSFLYMQKTLRQCQEQRQCHCRQEATNATRVIHDNYDQLEVHAAAIKSLGELDVFLAWINKNHEVMFSA
uniprot
proteins
function
FUNCTION: Cytokine that functions as an anti-inflammatory and proangiogenic factor (PubMed:34932373). Polarizes adaptive immunity to an anti-inflammatory phenotype through induction of T-helper 2 responses by both down-regulation of IFN-gamma and up-regulation of IL4 and IL13 (PubMed:16365913). Produced by osteocytes, stimulates granulopoiesis and neutrophil formation (By similarity). Exerts its biological effect through a receptor complex consisting of a heterodimer of IL20RA and IL20RB (PubMed:12351624). In turn, activates the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, and importantly, STAT3 (PubMed:11564763). {ECO:0000250|UniProtKB:Q8CJ70, ECO:0000269|PubMed:11564763, ECO:0000269|PubMed:12351624, ECO:0000269|PubMed:16365913, ECO:0000269|PubMed:34932373}.
uniprot
proteins
mass_dalton
20452
uniprot
proteins
protein_family
IL-10 family
uniprot
proteins
pubmed
11196675
uniprot
proteins
pubmed
11564763
uniprot
proteins
pubmed
12351624
uniprot
proteins
pubmed
12370360
uniprot
proteins
pubmed
12403790
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
16365913
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19906316
uniprot
proteins
pubmed
34932373
uniprot
proteins
sequence_length
177
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins