Pdcd10
entrez
494345
canonical
uniprot
Q6NX65
canonical
ensembl
ENSRNOG00000010147
resolver
ensp
ENSRNOP00000013585
resolver
ensp
ENSRNOP00000093534
resolver
genesymbol
Pdcd10
resolver
uniprot_entry
PDC10_RAT
resolver
amino_acid_sequence
MTMEEMKTEAEAASMVSMPLYAVMYPVFNELERVNLSAAQTLRAAFIKAEKENPGLTQDIIMKILEKKSVEVNFTESLLRMAADDVEEYMIERPEPEFQDLNEKARALKQILSKIPDEINDRVRFLQTIKDIASAIKELLDTVNNVFKKYQYQNRRALEHQKKEFVKYSKSFSDTLKTYFKDGKAINVFISANRLIHQTNLILQTFKTVA
uniprot
proteins
function
FUNCTION: Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity and STK26 activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (By similarity). Important for KDR/VEGFR2 signaling. Increases the stability of KDR/VEGFR2 and prevents its breakdown. Required for normal cardiovascular development. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). {ECO:0000250|UniProtKB:Q8VE70, ECO:0000250|UniProtKB:Q9BUL8}.
uniprot
proteins
mass_dalton
24355
uniprot
proteins
protein_family
PDCD10 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20332113
uniprot
proteins
sequence_length
210
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BUL8}. Golgi apparatus membrane {ECO:0000269|PubMed:20332113}; Peripheral membrane protein {ECO:0000269|PubMed:20332113}; Cytoplasmic side {ECO:0000269|PubMed:20332113}. Cell membrane {ECO:0000269|PubMed:20332113}; Peripheral membrane protein {ECO:0000269|PubMed:20332113}; Cytoplasmic side {ECO:0000269|PubMed:20332113}.
uniprot
proteins