CAPN10
entrez
11132
canonical
uniprot
Q9HC96
canonical
ensembl
ENSG00000142330
resolver
ensp
ENSP00000270362
resolver
ensp
ENSP00000375844
resolver
genesymbol
CAPN10
resolver
genesymbol_syn
KIAA1845
resolver
hgnc
HGNC:1477
resolver
uniprot
A8MVS7
resolver
uniprot
Q4ZFV1
resolver
uniprot
Q8NCD4
resolver
uniprot
Q96IG4
resolver
uniprot
Q96JI2
resolver
uniprot
Q9HC89
resolver
uniprot
Q9HC90
resolver
uniprot
Q9HC91
resolver
uniprot
Q9HC92
resolver
uniprot
Q9HC93
resolver
uniprot
Q9HC94
resolver
uniprot
Q9HC95
resolver
uniprot_entry
CAN10_HUMAN
resolver
uniprot_sec
A8MVS7
resolver
uniprot_sec
Q4ZFV1
resolver
uniprot_sec
Q8NCD4
resolver
uniprot_sec
Q96IG4
resolver
uniprot_sec
Q96JI2
resolver
uniprot_sec
Q9HC89
resolver
uniprot_sec
Q9HC90
resolver
uniprot_sec
Q9HC91
resolver
uniprot_sec
Q9HC92
resolver
uniprot_sec
Q9HC93
resolver
uniprot_sec
Q9HC94
resolver
uniprot_sec
Q9HC95
resolver
amino_acid_sequence
MRAGRGATPARELFRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDPREGQVKQGLLGDCWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTTDDRLPCLAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAERWNLKGVAGSGGQQDRPGRWEHRTCRQLLHLKDQCLISCCVLSPRAGARELGEFHAFIVSDLRELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQLQEGEFWVEEEEFLREFDELTVGYPVTEAGHLQSLYTERLLCHTRALPGAWVKGQSAGGCRNNSGFPSNPKFWLRVSEPSEVYIAVLQRSRLHAADWAGRARALVGDSHTSWSPASIPGKHYQAVGLHLWKVEKRRVNLPRVLSMPPVAGTACHAYDREVHLRCELSPGYYLAVPSTFLKDAPGEFLLRVFSTGRVSLSAIRAVAKNTTPGAALPAGEWGTVQLRGSWRVGQTAGGSRNFASYPTNPCFPFSVPEGPGPRCVRITLHQHCRPSDTEFHPIGFHIFQVPEGGRSQDAPPLLLQEPLLSCVPHRYAQEVSRLCLLPAGTYKVVPSTYLPDTEGAFTVTIATRIDRPSIHSQEMLGQFLQEVSIMAVMKT
uniprot
proteins
disease_involvement
DISEASE: Type 2 diabetes mellitus 1 (T2D1) [MIM:601283]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269|PubMed:11017071, ECO:0000269|PubMed:16721485}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.4.22.-
uniprot
proteins
function
FUNCTION: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. May play a role in insulin-stimulated glucose uptake. {ECO:0000269|PubMed:17572128}.
uniprot
proteins
mass_dalton
74952
uniprot
proteins
protein_family
Peptidase C2 family
uniprot
proteins
pubmed
11017071
uniprot
proteins
pubmed
11347906
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14759258
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16721485
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17572128
uniprot
proteins
sequence_length
672
uniprot
proteins