Pla2g4a
entrez
18783
canonical
uniprot
P47713
canonical
ensembl
ENSMUSG00000056220
resolver
ensp
ENSMUSP00000070868
resolver
ensp
ENSMUSP00000107557
resolver
enst
ENSMUST00000070200
resolver
enst
ENSMUST00000111926
resolver
genesymbol
Pla2g4a
resolver
genesymbol_syn
Cpla2
resolver
genesymbol_syn
Pla2g4
resolver
uniprot
F6RTC2
resolver
uniprot
Q3UMQ1
resolver
uniprot
Q9DBX5
resolver
uniprot_entry
F6RTC2_MOUSE
resolver
uniprot_entry
PA24A_MOUSE
resolver
uniprot_entry
Q3UMQ1_MOUSE
resolver
uniprot_entry
Q9DBX5_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Activated by cytosolic calcium, which is necessary for binding to membrane lipids (PubMed:1904318). Activated by phosphorylation in response to mitogenic stimuli (PubMed:10978317). Stimulated by agonists such as ATP and thrombin (PubMed:10978317). {ECO:0000269|PubMed:10978317, ECO:0000269|PubMed:1904318}.
uniprot
proteins
amino_acid_sequence
MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGTFGDMLDTPDPYVELFISTTPDSRKRTRHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFPVSSMKVGEKKEVPFIFNQVTEMILEMSLEVCSCPDLRFSMALCDQEKTFRQQRKENIKENMKKLLGPKKSEGLYSTRDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYIAGLSGSTWYMSTLYSHPDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIGETLIQNRMSMTLSSLKEKVNAARCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYGTFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQNKGSTMEEELENITAKHIVSNDSSDSDDEAQGPKGTENEEAEKEYQSDNQASWVHRMLMALVSDSALFNTREGRAGKVHNFMLGLNLNTSYPLSPLRDFSSQDSFDDELDAAVADPDEFERIYEPLDVKSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDTSPPFKELLLAEKWAKMNKLPFPKIDPYVFDREGLKECYVFKPKNPDVEKDCPTIIHFVLANINFRKYKAPGVLRETKEEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMYFNTLNNIDVIKDAIVESIEYRRQNPSRCSVSLSNVEARKFFNKEFLSKPTV
uniprot
proteins
ec_number
3.1.1.4
uniprot
proteins
ec_number
3.1.1.5
uniprot
proteins
function
FUNCTION: Has primarily calcium-dependent phospholipase and lysophospholipase activities, with a major role in membrane lipid remodeling and biosynthesis of lipid mediators of the inflammatory response (PubMed:1904318, PubMed:9403692, PubMed:9403693). Plays an important role in embryo implantation and parturition through its ability to trigger prostanoid production (PubMed:9403692, PubMed:9403693). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis via the cyclooxygenase pathway. In an alternative pathway of eicosanoid biosynthesis, hydrolyzes sn-2 fatty acyl chain of eicosanoid lysophospholipids to release free bioactive eicosanoids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-1 position of phospholipids (phospholipase A1 activity) only if an ether linkage rather than an ester linkage is present at the sn-2 position. This hydrolysis is not stereospecific. Has calcium-independent phospholipase A2 and lysophospholipase activities in the presence of phosphoinositides. Has O-acyltransferase activity. Catalyzes the transfer of fatty acyl chains from phospholipids to a primary hydroxyl group of glycerol (sn-1 or sn-3), potentially contributing to monoacylglycerol synthesis (By similarity). {ECO:0000250|UniProtKB:P47712, ECO:0000269|PubMed:1904318, ECO:0000269|PubMed:9403692, ECO:0000269|PubMed:9403693}.
uniprot
proteins
mass_dalton
85222
uniprot
proteins
pathway_participation
PATHWAY: Membrane lipid metabolism; glycerophospholipid metabolism. {ECO:0000269|PubMed:1904318}.; PATHWAY: Lipid metabolism; arachidonate metabolism. {ECO:0000269|PubMed:9403692}.; PATHWAY: Lipid metabolism; prostaglandin biosynthesis. {ECO:0000269|PubMed:9403692}.; PATHWAY: Lipid metabolism; leukotriene B4 biosynthesis. {ECO:0000250|UniProtKB:P47712}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at both Ser-505 and Ser-726 in response to mitogenic stimuli. {ECO:0000269|PubMed:10978317}.
uniprot
proteins
pubmed
10978317
uniprot
proteins
pubmed
11984592
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16172261
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
1904318
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9403692
uniprot
proteins
pubmed
9403693
uniprot
proteins
sequence_length
748
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P47712}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P47712}. Nucleus envelope {ECO:0000250|UniProtKB:P47712}. Note=Translocates to intracellular membranes in a calcium-dependent way. {ECO:0000250|UniProtKB:P47712}.
uniprot
proteins