Acsl4
entrez
50790
canonical
uniprot
Q9QUJ7
canonical
ensembl
ENSMUSG00000031278
resolver
ensp
ENSMUSP00000033634
resolver
ensp
ENSMUSP00000108524
resolver
ensp
ENSMUSP00000108525
resolver
ensp
ENSMUSP00000186937
resolver
ensp
ENSMUSP00000186938
resolver
ensp
ENSMUSP00000186941
resolver
genesymbol
Acsl4
resolver
genesymbol_syn
Acs4
resolver
genesymbol_syn
Facl4
resolver
uniprot
Q5D071
resolver
uniprot
Q8BW44
resolver
uniprot
Q91YN3
resolver
uniprot
Q9JHT4
resolver
uniprot
Q9R0H3
resolver
uniprot_entry
ACSL4_MOUSE
resolver
uniprot_entry
Q8BW44_MOUSE
resolver
uniprot_entry
Q91YN3_MOUSE
resolver
uniprot_sec
Q5D071
resolver
uniprot_sec
Q9JHT4
resolver
uniprot_sec
Q9R0H3
resolver
activity_regulation
ACTIVITY REGULATION: Both triacsin C and rosiglitazone inhibit arachidonoyl-CoA ligase activity. {ECO:0000250|UniProtKB:O60488}.
uniprot
proteins
amino_acid_sequence
MNLKLNVLTIILLPVHLLITIYSALIFIPWYFLTNAKKKNAMAKRIKAKPTSDKPGSPYRSVTHFDSLAVIDIPGADTLDKLFDHAVAKFGKKDSLGTREILSEENEMQPNGKVFKKLILGNYKWINYLEVNCRVNNFGSGLTALGLKPKNTIAIFCETRAEWMIAAQTCFKYNFPLVTLYATLGREAVVHGLNESEASYLITSVELLESKLKAALVDINCVKHIIYVDNKTINRAEYPEGLEIHSMQSVEELGAKPENLSVPPSRPTPSDMAIVMYTSGSTGRPKGVMMHHSNLIAGMTGQCERIPGLGPKDTYIGYLPLAHVLELTAEISCFTYGCRIGYSSPLTLSDQSSKIKKGSKGDCTVLKPTLMAAVPEIMDRIYKNVMSKVQEMNYVQKTLFKIGYDYKLEQIKKGYDAPLCNLILFKKVKALLGGNVRMMLSGGAPLSPQTHRFMNVCFCCPIGQGYGLTESCGAGTVTEVTDYTTGRVGAPLICCEIKLKDWQEGGYTVHDKPNPRGEIVIGGQNISMGYFKNEEKTAEDYCVDENGQRWFCTGDIGEFHPDGCLQIIDRKKDLVKLQAGEYVSLGKVEAALKNCPLIDNICAFAKSDQSYVISFVVPNQKKLTLLAQQKGVEGSWVDICNNPAMEAEILKEIREAANAMKLERFEIPIKVRLSPEPWTPETGLVTDAFKLKRKELKNHYLKDIERMYGGK
uniprot
proteins
ec_number
6.2.1.15
uniprot
proteins
ec_number
6.2.1.3
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET (By similarity). Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion. Acts as an activator of ferroptosis by activating polyunsaturated fatty acids, especially arachidonate and adrenate, to their active form, generating the primary lipid-peroxidation substrates that contribute to ferroptosis (By similarity). {ECO:0000250|UniProtKB:O35547, ECO:0000250|UniProtKB:O60488}.
uniprot
proteins
mass_dalton
79077
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-328 by isoform Beta-II of PRKCB promotes activation and lipid peroxidation, thereby inducing ferroptosis. Phosphorylation at Thr-679 by PCK2 promotes ferroptosis. {ECO:0000250|UniProtKB:O60488}.
uniprot
proteins
protein_family
ATP-dependent AMP-binding enzyme family
uniprot
proteins
pubmed
10828604
uniprot
proteins
pubmed
10924347
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
711
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:O60488}; Single-pass type III membrane protein {ECO:0000250|UniProtKB:O60488}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O60488}; Single-pass type III membrane protein {ECO:0000250|UniProtKB:O60488}. Cell membrane {ECO:0000250|UniProtKB:O60488}; Single-pass type III membrane protein {ECO:0000250|UniProtKB:O60488}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins