Drc4
entrez
361438
canonical
uniprot
Q499U4
canonical
ensembl
ENSRNOG00000026964
resolver
ensp
ENSRNOP00000084663
resolver
ensp
ENSRNOP00000107041
resolver
enst
ENSRNOT00000101403
resolver
genesymbol
Drc4
resolver
genesymbol_syn
Gas11
resolver
genesymbol_syn
Gas8
resolver
uniprot
A0A8I5ZZT3
resolver
uniprot_entry
A0A8I5ZZT3_RAT
resolver
uniprot_entry
DRC4_RAT
resolver
amino_acid_sequence
MAPKRRGKKGKAKGNAVVDGVAPEDMSKEQVEEHVARIREELDREREERNYFQLERDKIHTFWEITRRQLEEKKAELRNKDREMEEAEERHQVEIKVYKQKVKHLLYEHQNNLAEVKTEGTVVMKLAQKEHRAQEGALRKDMRVLKVELKEQELANEVVIKNLRLKQAEEITKMRNDFERQVREIEAKYDKKMKMLRDELDLRRKTEIHEVEERKNGQISTLMQRHEEAFTDIKNYYNDITLNNLALINSLKEQMEDMRKKEEYLEREMAEVSLQNKRLAEPLQRAKEEMSEMQKRLGNHERDKQILACTKARLKVTEKELKDLKWEHEILEQRFIKVQQEREELYRKFTAAIQEVQQKTGFKNLVLERKLQALNAAVEKREVQFNEVLAASNLDPTALTLVSRKLEDVLESKNTTIKDLQYELARVCKAHNDLLRTYEAKLLAFGIPLDNVGFKPLETAVIGQTLGQGPAGLVGAPT
uniprot
proteins
function
FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays an important role in the assembly of the N-DRC linker. Plays dual roles at both the primary (or non-motile) cilia to regulate hedgehog signaling and in motile cilia to coordinate cilia movement. Required for proper motile cilia functioning. Positively regulates ciliary smoothened (SMO)-dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity in a GRK2-dependent manner. {ECO:0000250|UniProtKB:Q60779, ECO:0000250|UniProtKB:Q7XJ96}.
uniprot
proteins
mass_dalton
56313
uniprot
proteins
protein_family
DRC4 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
478
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q60779}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O95995}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q60779}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:O95995}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q60779}. Golgi apparatus {ECO:0000250|UniProtKB:O95995}. Cell projection, cilium {ECO:0000250|UniProtKB:O95995}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q7XJ96}. Note=Associates with microtubules. Localized to the cytoplasm of round spermatids, the tails of elongating spermatids, and mature spermatid tail bundles protruding into the lumen, and in the flagellum of epididymal spermatozoa. {ECO:0000250|UniProtKB:O95995, ECO:0000250|UniProtKB:Q60779}.
uniprot
proteins