PIAS2
entrez
9063
canonical
uniprot
O75928
canonical
ensembl
ENSG00000078043
resolver
ensp
ENSP00000317163
resolver
ensp
ENSP00000465676
resolver
ensp
ENSP00000479025
resolver
ensp
ENSP00000532944
resolver
genesymbol
PIAS2
resolver
genesymbol_syn
PIASX
resolver
hgnc
HGNC:17311
resolver
uniprot
O75927
resolver
uniprot
Q2TA77
resolver
uniprot
Q96BT5
resolver
uniprot
Q96KE3
resolver
uniprot_entry
PIAS2_HUMAN
resolver
uniprot_entry
Q2TA77_HUMAN
resolver
uniprot_sec
O75927
resolver
uniprot_sec
Q96BT5
resolver
uniprot_sec
Q96KE3
resolver
amino_acid_sequence
MADFEELRNMVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIRELYRRRYPRTLEGLSDLSTIKSSVFSLDGGSSPVEPDLAVAGIHSLPSTSVTPHSPSSPVGSVLLQDTKPTFEMQQPSPPIPPVHPDVQLKNLPFYDVLDVLIKPTSLVQSSIQRFQEKFFIFALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAVTCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDCSDVDEIKFQEDGSWCPMRPKKEAMKVSSQPCTKIESSSVLSKPCSVTVASEASKKKVDVIDLTIESSSDEEEDPPAKRKCIFMSETQSSPTKGVLMYQPSSVRVPSVTSVDPAAIPPSLTDYSVPFHHTPISSMSSDLPGLDFLSLIPVDPQYCPPMFLDSLTSPLTASSTSVTTTSSHESSTHVSSSSSRSETGVITSSGSNIPDIISLD
uniprot
proteins
ec_number
2.3.2.-
uniprot
proteins
function
FUNCTION: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulator in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and the PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIAS2-beta, but not isoform PIAS2-alpha, promotes MDM2 sumoylation. Isoform PIAS2-alpha promotes PARK7 sumoylation. Isoform PIAS2-beta promotes NCOA2 sumoylation more efficiently than isoform PIAS2-alpha. Isoform PIAS2-alpha sumoylates PML at'Lys-65' and 'Lys-160'. {ECO:0000269|PubMed:15920481, ECO:0000269|PubMed:15976810, ECO:0000269|PubMed:22406621}.
uniprot
proteins
mass_dalton
68240
uniprot
proteins
mutagenesis
MUTAGEN 362; /note="C->S,A: Loss of MDM2 and TP53 sumoylation and of autosumoylation; no loss of JUN- and TP53-binding."; /evidence="ECO:0000269|PubMed:11867732, ECO:0000269|PubMed:12393906"; MUTAGEN 467; /note="V->A: Reduces affinity for SUMO1."; /evidence="ECO:0000269|PubMed:16204249"; MUTAGEN 469; /note="V->A: Abolishes binding to SUMO1."; /evidence="ECO:0000269|PubMed:16204249"; MUTAGEN 470; /note="I->A: Abolishes binding to SUMO1."; /evidence="ECO:0000269|PubMed:16204249"; MUTAGEN 472; /note="L->A: Abolishes binding to SUMO1."; /evidence="ECO:0000269|PubMed:16204249"; MUTAGEN 473; /note="T->A: Reduces affinity for SUMO1."; /evidence="ECO:0000269|PubMed:16204249
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein sumoylation.
uniprot
proteins
post_translational_modification
PTM: Sumoylated. {ECO:0000269|PubMed:11867732, ECO:0000269|PubMed:12393906}.
uniprot
proteins
protein_family
PIAS family
uniprot
proteins
pubmed
10961991
uniprot
proteins
pubmed
11439351
uniprot
proteins
pubmed
11477070
uniprot
proteins
pubmed
11867732
uniprot
proteins
pubmed
12223491
uniprot
proteins
pubmed
12393906
uniprot
proteins
pubmed
12716907
uniprot
proteins
pubmed
15208321
uniprot
proteins
pubmed
15301740
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15920481
uniprot
proteins
pubmed
15976810
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
16204249
uniprot
proteins
pubmed
16617055
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21156324
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22406621
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28842558
uniprot
proteins
pubmed
9724754
uniprot
proteins
pubmed
9920921
uniprot
proteins
sequence_length
621
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q8C5D8}. Nucleus, PML body {ECO:0000269|PubMed:12716907, ECO:0000269|PubMed:22406621}. Nucleus {ECO:0000269|PubMed:11477070, ECO:0000269|PubMed:12393906}. Note=Colocalizes at least partially with promyelocytic leukemia nuclear bodies (PML NBs) (PubMed:22406621). Colocalizes with SUMO1 in nuclear granules (By similarity). {ECO:0000250|UniProtKB:Q8C5D8, ECO:0000269|PubMed:22406621}.
uniprot
proteins