Nmi
entrez
64685
canonical
uniprot
O35309
canonical
ensembl
ENSMUSG00000026946
resolver
ensp
ENSMUSP00000028314
resolver
ensp
ENSMUSP00000108325
resolver
ensp
ENSMUSP00000120647
resolver
ensp
ENSMUSP00000268396
resolver
enst
ENSMUST00000028314
resolver
enst
ENSMUST00000112705
resolver
enst
ENSMUST00000145481
resolver
genesymbol
Nmi
resolver
uniprot
Q3UJ82
resolver
uniprot
Q99M49
resolver
uniprot_entry
NMI_MOUSE
resolver
uniprot_entry
Q3UJ82_MOUSE
resolver
uniprot_sec
Q99M49
resolver
amino_acid_sequence
MDADKDNIKQACDERSAEMDDMRGEQSMGLVHEIMSENKELDEEIKKLEAELQSDAREFQIKENVPEKKLKLTSVESPKDGCHFSNSSCSFQVSSQILYELQEGQALITFEKEEVAQNVISMGNHVVQMEGTPVKVSAHPVPLNTGVRFQVHVDISKMKINVTGIPDELSEEQTRDKLELSFCKSRNGGGEVESVDYDRKSRSAVITFVETGVVDKILKKKTYPLYMNQKCHSVAVSPCIERCLEKYQVFSAVSKKTVLLTGLEGIPVDEETGEDLLNIHFQRKNNGGGEVEVVKCSLDQSFAAYFKEEARETI
uniprot
proteins
function
FUNCTION: Acts as a signaling pathway regulator involved in innate immune system response (PubMed:23956435). In response to interleukin 2/IL2 and interferon IFN-gamma/IFNG, interacts with signal transducer and activator of transcription/STAT which activate the transcription of downstream genes involved in a multitude of signals for development and homeostasis (By similarity). Enhances the recruitment of CBP/p300 coactivators to STAT1 and STAT5, resulting in increased STAT1- and STAT5-dependent transcription (By similarity). In response to interferon IFN-alpha, associates in a complex with transcriptional regulator IFI35 to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 (By similarity). In complex with IFI35, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (By similarity). Negatively regulates virus-triggered type I interferon/IFN production by inducing proteosome-dependent degradation of IRF7, a transcriptional regulator of type I IFN, thereby interfering with cellular antiviral responses (PubMed:23956435). Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation, when actively released by macrophage to the extracellular space during cell injury or pathogen invasion (By similarity). Macrophage-secreted NMI activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 binding and activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of pro-inflammatory cytokines (By similarity). {ECO:0000250|UniProtKB:Q13287, ECO:0000269|PubMed:23956435}.
uniprot
proteins
mass_dalton
35236
uniprot
proteins
post_translational_modification
PTM: May be ubiquitinated. {ECO:0000250|UniProtKB:Q13287}.
uniprot
proteins
protein_family
NMI family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23956435
uniprot
proteins
pubmed
29038465
uniprot
proteins
sequence_length
314
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q13287}. Nucleus {ECO:0000250|UniProtKB:Q13287}. Secreted {ECO:0000250|UniProtKB:Q13287}. Note=Cytoplasmic NMI localizes in punctate granular structures. Nuclear localization increased following IFN-alpha treatment. Extracellular following secretion by macrophage. {ECO:0000250|UniProtKB:Q13287}.
uniprot
proteins