Lurap1
entrez
500527
canonical
uniprot
D4A8G3
canonical
ensembl
ENSRNOG00000085055
resolver
ensp
ENSRNOP00000100156
resolver
genesymbol
Lurap1
resolver
genesymbol_syn
Lrap35a
resolver
genesymbol_syn
Lrp35a
resolver
uniprot_entry
LURA1_RAT
resolver
amino_acid_sequence
MEGTAESQTPDLRDVEGKVGRKTPEGLLRGLRGECDLGTSGDVLLPGASSTGHGLGDKIMALRMELAYLRAIDVKILQQLVTLNEGIEAVRWLLEERGTLTSHCSSLTSSQYSLTGGSPERSRRGSWDSLPDTSSTDRLDSVSIGSFLDTVAPRELDEQGHPGPSCPEIDWAKVIPSEDRARTEVDMTSTKLGSLTATWKLPGDGLQCGPPEPSEDDSAKQGFEAHWYWGQCQDDVTFL
uniprot
proteins
function
FUNCTION: Acts as an activator of the canonical NF-kappa-B pathway and drive the production of pro-inflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway (By similarity). In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella. {ECO:0000250, ECO:0000269|PubMed:18854160}.
uniprot
proteins
mass_dalton
25891
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000269|PubMed:18854160}.
uniprot
proteins
pubmed
18854160
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
25107909
uniprot
proteins
sequence_length
239
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96LR2}.
uniprot
proteins