B7ZCC9
uniprot
B7ZCC9
canonical
activity_regulation
ACTIVITY REGULATION: Forms a heterodimer of 2 chains generated by proteolytic processing that remain associated through non-covalent interactions mediated by the GAIN-B domain (By similarity). In the inactivated receptor, the Stachel sequence (also named stalk) is embedded in the GAIN-B domain, where it adopts a beta-strand conformation. On activation, the Stachel moves into the 7 transmembrane region and adopts a twisted hook-shaped configuration that forms contacts within the receptor, leading to coupling of a G-alpha protein, which activates signaling. The cleaved GAIN-B and N-terminal domains can then dissociate from the rest of the receptor (By similarity). {ECO:0000250|UniProtKB:Q8IZF6, ECO:0000255|PROSITE-ProRule:PRU00098}.
uniprot
proteins
amino_acid_sequence
MRKHILHQRLCGLILVSSFIFLTDSLSLKGKRLDFYGEGKAYVSLTYTMPELSRLTACIDLISMTNSSHYWMAFIYITNNTLLGREDVDLGLAGDHQQLILYSFGKTFYVSYHLIPFHWHTLCLVWDGVKGRLELFRNKERILAIMDQPHRLSPNGTLVLGHFPRNGEGQIKTVIPRFTSSLYYFQLWDRILENEEFMTCFYGNVVSWEDDVWLIHKISPTVDRRLRCFVSENMTIQETSTNVSQQIDLTTSSQTTGLNPHKTSHSSTLLPEGMADSTINSTAISYANTVPSPLATVSAAKDLKTSTTETATFLTDTLFTSTATPLPTQTVTEHSYLGKTRTSKRVEAMATEIFHSATATDLIDTSVFTKNYTVSETSTTKSKSAVGKTTLFLNESTSIAPTPCPKHKSTDVAILHTSKSGQEFLVSSAARTVSWSTLEETSPITTDVGIVSTFPPESLLTSTASPVSSTFPEIQLASTLSTTDSEMASTVHSVLPMQTIPTPRTVKPESGSTNFQDVFSPSMEDALSVSMPKETTFMAFSSITSSPITRTQDEQIAIDAESTHLTIIPGTKFVPTLAEASLFPTIEGQAYTQDTPTTDEPMLTLTSTKSPSTYNASESVLTSITIKSDYQFFTNETTWTSKSGQNLLTSMNTTTIPTFTSNKTLTLPFQGNATNRDHSSMTTNVSPIEASTESKVTTSSDATTASYTTALFKPTSQWLSHFTSVSGITSIASQPESKLTTLLLKSNSMPTVATNEFPSIPSEPVAPSVNTSTLTDIKPNFSTEKSISETIQIETNGVSSFGDTLAPLPMSATTQRVYTTVTKETTSRHPKVKSTISTVAEASPFSTMLEVTDESEQMVTASVTISPFTDIEKLTTALSKETATAEVGVSWLSTKLKESMPESSHNGTTESFNSTHTYTVDWTSEKSKGNSASSPNSASTQALPELPSSSTMKTMGVTFSTNSSQRTAASLSAGILSPQTASTHALVTPQLLTHTFSLPVNISAVTSPKTTMVFFDETKVTLSQPSTLARDFTTSMPSVGSTLPTVTMTTELVPPVSPTASTISDSMFTHRDLLHTTSEVTTISSTTAHMAISSLRETLVSSLRPPTPVITKAISTIPSISSDSVSPSIHTLVCSRPSPNNVTIVSSTYVSSTTSTSVATPSESHFSFPYAFSSGGDVTMASGPTGTSAGGEAMPPNTFVNKFITSVDHESTTYFVNTPVSTQSVFATSMVSSDKEQTNISMEKTLRTTGVAEISPSKNSFILDSQSTFPWEMTDTELSETTEISSHQTHLPSEILPGYSDSGNLTTFSTSGSTQSAQTLSSSTIIGVRVSEGSTSLEKTALPSQVQTVTKSLTHDKERTSALSEYPPRTVEKIMSSSPVTHQATGHLATSIVDASRTTRISHPVLINTTLSYLLSLKTKPEATQIASSTSGSTENFPNSFSPFTTGLLSTNFTMITPNGSTTVLSIPNEPTNLPKKTSMEASTPISQMDLLALNVTAFTSKKVSDTHTMLMTKSSRTIHIGTLKSVSIGTFGLKSEKSEMPVNNSDFSTTVLYSDTSTRLGEFFTSSSSLPPKATKTTQASTLNTTPVAHAGPTSQRTVFSSTFSNSSVVEVPLNYTTAHFSSPTQRGFLSMKTIPTTSMAGISTSVIGATSSSLSSSKNTEPISSIPKTMFSLLLSTTQQPSQENGAPTLDILPGITVSSGGATDLINANSRATIPANELSTTPSDNFYTFLNTQDSPTLTNSKVTPRPTESVKSTPTHLSFDTRKMNILTELTKSGPCVTTPVLYPLWTQTSTAPPLTSHLYSPHSTKAKFPLASQMAEYPAWATGITPSITQALLTTSRNTQRVEDSPFPVFTTKVMTPNRMEVETLHSPSGTLATSTTSQIGLVSRDVTVMPLISTSESLPSLGISESTSLSISSTFPPTTLAAILPTFEKTAMPVTPGITLSSNPSVNSRATSPTWSSSSLPSDSRASIFTPSRLLTSSSGEMSESTFPASDIIATYSNFTVAPLSDGSATIATQATSTTTLDIITANSLTSPPIPSKDKDGSLHTSTFLESSLRTTGADSSTDMSERMSFGRTSISPSLTRHDLSIGSLTVSSPTNTSPWSKVPVTSESHTLFPSKSTLDSVMSTATTTSTAIGTSFPLMSTEMAHPSTATGFSLVSSSFETTWMDSIFSSLFTQPSTSPTAKESTVSFYNIKMSFSVFDEEPRVLVTTVIHDLTKDWLNFMFQNSEFSLANLAIQIKSRKTSKEETAMYRYILEQKKGQGMDAIFHVPYSCACWVIIKAKSSLESVELISSIRTKIHGNLTHGNFTQDQLTLLVKSDHVVVEKLEPGKCEADETPSKYKGTYKWPLTDPTETAQERCIKNENRNATRICSISIQTGKCQWEKPRLKQCKLLQGLPDKIVDLANITISDENADDVAEHILNLVNESPPLDEEETKIIVSKVADISNCDEISINLTQIILQILNTVTEKQSDSASNLPPVSNEILRIIERVGHKMEFAGRTANLTVAKLALAVLRVDHKFEGMAFSIQSSEEVIAPQIFLGDIPLRKALASIYLPKSLREKVPLDGLQTILFNFFGQTSLFKAKTITSELMTYVVSASISNTSIQNLADPVIIILKHIQGDWNYDQVYCAFWDFDTNNGLGGWNPSGCKLKESNINYTICQCNHLTHFGVLMDLSRSTVDAVNERILVIITYTGCGISSIFLGIAMVTYIAFHKLRKDYPSKILINLCTALLMLNLAFLVNSWLTSFQKVGLCITAAVALHYFLLVSLTWMGLEAVHMYFALVKVFNTYIPNYILKFCLAGWGIPAITVAIILSVRKDLYGTLSPTTPFCWIKDDHIFYISVVAYFCLIFLMNLSMFCTVLVQLTSVKSQSQKTRKKMILNDLKGTISLTFLLGLTWGFAFFAWGPVRIFFLYLFAICNTLQGFLIFVFYCVMKESVREQWHMPLHCRWLRLENFAGWINVRHKQKRLKKNNESKLLTPSLMSTTTFKSIGSVPSIPSEINFSNGDFDDSPDTFSFLSCKAAPTFIRRALPAEIQTNSTQKQRSFPINVSRDTHLTPSSGLGEMFNL
uniprot
proteins
function
FUNCTION: Orphan adhesion G protein-coupled receptor (aGPCR). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). ADGRG4 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. May be act as sensor of mechanical forces (By similarity). {ECO:0000250|UniProtKB:Q8CJ12, ECO:0000250|UniProtKB:Q8IZF6}.
uniprot
proteins
mass_dalton
334211
uniprot
proteins
post_translational_modification
PTM: Autoproteolytically processed at the GPS region of the GAIN-B domain; this cleavage modulates receptor activity. {ECO:0000250|UniProtKB:Q8IZF6}.
uniprot
proteins
protein_family
Adhesion G protein-coupled receptor (ADGR) subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 2 family
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
3073
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8IZF6}.
uniprot
proteins
transmembrane_region
TRANSMEM 2692..2712; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 2729..2749; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 2756..2776; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 2799..2819; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 2843..2863; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 2893..2913; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 2915..2935; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins