Sucnr1
entrez
84112
canonical
uniprot
Q99MT6
canonical
ensembl
ENSMUSG00000027762
resolver
ensp
ENSMUSP00000029326
resolver
enst
ENSMUST00000029326
resolver
genesymbol
Sucnr1
resolver
genesymbol_syn
Gpr91
resolver
uniprot
Q4V9V9
resolver
uniprot_entry
SUCR1_MOUSE
resolver
uniprot_sec
Q4V9V9
resolver
amino_acid_sequence
MAQNLSCENWLATEAILNKYYLSAFYAIEFIFGLLGNVTVVFGYLFCMKNWNSSNVYLFNLSISDFAFLCTLPILIKSYANDKGTYGDVLCISNRYVLHTNLYTSILFLTFISMDRYLLMKYPFREHFLQKKEFAILISLAVWALVTLEVLPMLTFINSVPKEEGSNCIDYASSGNPEHNLIYSLCLTLLGFLIPLSVMCFFYYKMVVFLKRRSQQQATALPLDKPQRLVVLAVVIFSILFTPYHIMRNLRIASRLDSWPQGCTQKAIKSIYTLTRPLAFLNSAINPIFYFLMGDHYREMLISKFRQYFKSLTSFRT
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for succinate able to mediate signaling through Gq/GNAQ or Gi/GNAI second messengers depending on the cell type and the processes regulated (PubMed:15141213). Succinate-SUCNR1 signaling serves as a link between metabolic stress, inflammation and energy homeostasis (PubMed:18820681, PubMed:27481132, PubMed:29735652, PubMed:30962591). In macrophages, plays a range of immune-regulatory roles. During inflammation, succinate-SUCNR1 signaling may act as an anti-inflammatory mediator or boost inflammation depending on the inflammatory status of cells (PubMed:27481132, PubMed:30962591). Hyperpolarizes M2 macrophages versus M1 phenotype through Gq signaling by regulating the transcription of genes involved in immune function (By similarity). In activated M1 macrophages, plays a pro-inflammatory role in response to LPS (PubMed:27481132). Expressed in dendritic cells, where it is involved in the sensing of immunological danger and enhances immunity. Mediates succinate triggered intracelleular calcium mobilization, induces migratory responses and acts in synergy with Toll-like receptor ligands for the production of proinflammatory cytokines as well as an enhancement of antigen-specific activation of helper T cells (PubMed:18820681). In the small intestine, mediates the activation of tuft cells by dietary succinate and triggers type 2 immunity (PubMed:29735652). In adipocytes, plays an important role in the control of energy metabolism. In response to succinate, controls leptin expression in an AMPK-JNK-CEBPA-dependent as well as circadian clock-regulated manner (PubMed:36977414). In muscle tissue, is expressed in non-muscle cells and coordinates muscle remodeling in response to the succinate produced during exercise training in a paracrine manner (PubMed:32946811). In retina, acts as a mediator of vessel growth during retinal development. In response to succinate, regulates the production of angiogenic factors, including VEGF, by retinal ganglion neurons (By similarity). {ECO:0000250|UniProtKB:Q6IYF9, ECO:0000250|UniProtKB:Q9BXA5, ECO:0000269|PubMed:15141213, ECO:0000269|PubMed:18820681, ECO:0000269|PubMed:27481132, ECO:0000269|PubMed:29735652, ECO:0000269|PubMed:30962591, ECO:0000269|PubMed:32946811, ECO:0000269|PubMed:36977414}.
uniprot
proteins
mass_dalton
36765
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11273702
uniprot
proteins
pubmed
15141213
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18820681
uniprot
proteins
pubmed
27481132
uniprot
proteins
pubmed
29735652
uniprot
proteins
pubmed
30962591
uniprot
proteins
pubmed
32946811
uniprot
proteins
pubmed
36977414
uniprot
proteins
sequence_length
317
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:29735652}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 24..47; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 56..76; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 102..119; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 134..157; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 181..204; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 229..246; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 278..294; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins