Gata3
entrez
14462
canonical
uniprot
P23772
canonical
ensembl
ENSMUSG00000015619
resolver
ensp
ENSMUSP00000100041
resolver
ensp
ENSMUSP00000252619
resolver
ensp
ENSMUSP00000252620
resolver
ensp
ENSMUSP00000252621
resolver
ensp
ENSMUSP00000252622
resolver
ensp
ENSMUSP00000252623
resolver
ensp
ENSMUSP00000252624
resolver
enst
ENSMUST00000102976
resolver
genesymbol
Gata3
resolver
genesymbol_syn
Gata-3
resolver
uniprot
Q3U0R5
resolver
uniprot_entry
GATA3_MOUSE
resolver
uniprot_entry
Q3U0R5_MOUSE
resolver
amino_acid_sequence
MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLGHSYMEAQYPLTEEVDVLFNIDGQGNHVPSYYGNSVRATVQRYPPTHHGSQVCRPPLLHGSLPWLDGGKALSSHHTASPWNLSPFSKTSIHHGSPGPLSVYPPASSSSLAAGHSSPHLFTFPPTPPKDVSPDPSLSTPGSAGSARQDEKECLKYQVQLPDSMKLETSHSRGSMTTLGGASSSAHHPITTYPPYVPEYSSGLFPPSSLLGGSPTGFGCKSRPKARSSTEGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKEGIQTRNRKMSSKSKKCKKVHDALEDFPKSSSFNPAALSRHMSSLSHISPFSHSSHMLTTPTPMHPPSGLSFGPHHPSSMVTAMG
uniprot
proteins
function
FUNCTION: Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression (PubMed:31175139). Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages. {ECO:0000269|PubMed:17056504, ECO:0000269|PubMed:31175139, ECO:0000269|PubMed:34644537}.
uniprot
proteins
mass_dalton
47968
uniprot
proteins
mutagenesis
MUTAGEN 344; /note="Y->A: Dramatically decreased Th2 cell differentiation."; /evidence="ECO:0000269|PubMed:17056504"; MUTAGEN 346; /note="K->A: Moderately decreased Th2 cell differentiation."; /evidence="ECO:0000269|PubMed:17056504"; MUTAGEN 348; /note="H->A: Dramatically decreased Th2 cell differentiation."; /evidence="ECO:0000269|PubMed:17056504"; MUTAGEN 352; /note="R->A: Fails to induce Th2 cytokine production."; /evidence="ECO:0000269|PubMed:17056504"; MUTAGEN 353; /note="P->A,K: Fails to induce Th2 cytokine production."; /evidence="ECO:0000269|PubMed:17056504
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15662016
uniprot
proteins
pubmed
17056504
uniprot
proteins
pubmed
18621058
uniprot
proteins
pubmed
2017177
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21690296
uniprot
proteins
pubmed
23616576
uniprot
proteins
pubmed
31175139
uniprot
proteins
pubmed
34644537
uniprot
proteins
sequence_length
443
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15662016, ECO:0000269|PubMed:34644537}.
uniprot
proteins