BRD1
entrez
23774
canonical
uniprot
O95696
canonical
ensembl
ENSG00000100425
resolver
ensp
ENSP00000216267
resolver
ensp
ENSP00000384076
resolver
ensp
ENSP00000385858
resolver
ensp
ENSP00000566341
resolver
ensp
ENSP00000566342
resolver
ensp
ENSP00000605115
resolver
ensp
ENSP00000605121
resolver
ensp
ENSP00000613609
resolver
ensp
ENSP00000613610
resolver
ensp
ENSP00000613611
resolver
genesymbol
BRD1
resolver
genesymbol_syn
BRL
resolver
genesymbol_syn
BRPF2
resolver
hgnc
HGNC:1102
resolver
uniprot
A6ZJA4
resolver
uniprot
Q59G93
resolver
uniprot_entry
BRD1_HUMAN
resolver
uniprot_entry
Q59G93_HUMAN
resolver
uniprot_sec
A6ZJA4
resolver
amino_acid_sequence
MRRKGRCHRGSAARHPSSPCSVKHSPTRETLTYAQAQRMVEIEIEGRLHRISIFDPLEIILEDDLTAQEMSECNSNKENSERPPVCLRTKRHKNNRVKKKNEALPSAHGTPASASALPEPKVRIVEYSPPSAPRRPPVYYKFIEKSAEELDNEVEYDMDEEDYAWLEIVNEKRKGDCVPAVSQSMFEFLMDRFEKESHCENQKQGEQQSLIDEDAVCCICMDGECQNSNVILFCDMCNLAVHQECYGVPYIPEGQWLCRHCLQSRARPADCVLCPNKGGAFKKTDDDRWGHVVCALWIPEVGFANTVFIEPIDGVRNIPPARWKLTCYLCKQKGVGACIQCHKANCYTAFHVTCAQKAGLYMKMEPVKELTGGGTTFSVRKTAYCDVHTPPGCTRRPLNIYGDVEMKNGVCRKESSVKTVRSTSKVRKKAKKAKKALAEPCAVLPTVCAPYIPPQRLNRIANQVAIQRKKQFVERAHSYWLLKRLSRNGAPLLRRLQSSLQSQRSSQQRENDEEMKAAKEKLKYWQRLRHDLERARLLIELLRKREKLKREQVKVEQVAMELRLTPLTVLLRSVLDQLQDKDPARIFAQPVSLKEVPDYLDHIKHPMDFATMRKRLEAQGYKNLHEFEEDFDLIIDNCMKYNARDTVFYRAAVRLRDQGGVVLRQARREVDSIGLEEASGMHLPERPAAAPRRPFSWEDVDRLLDPANRAHLGLEEQLRELLDMLDLTCAMKSSGSRSKRAKLLKKEIALLRNKLSQQHSQPLPTGPGLEGFEEDGAALGPEAGEEVLPRLETLLQPRKRSRSTCGDSEVEEESPGKRLDAGLTNGFGGARSEQEPGGGLGRKATPRRRCASESSISSSNSPLCDSSFNAPKCGRGKPALVRRHTLEDRSELISCIENGNYAKAARIAAEVGQSSMWISTDAAASVLEPLKVVWAKCSGYPSYPALIIDPKMPRVPGHHNGVTIPAPPLDVLKIGEHMQTKSDEKLFLVLFFDNKRSWQWLPKSKMVPLGIDETIDKLKMMEGRNSSIRKAVRIAFDRAMNHLSRVHGEPTSDLSDID
uniprot
proteins
function
FUNCTION: Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:16387653, PubMed:21753189, PubMed:21880731). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation (PubMed:21753189). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21880731}.
uniprot
proteins
mass_dalton
119520
uniprot
proteins
mutagenesis
MUTAGEN 41..45; /note="EIEIE->AIAIA,KIKIK: Decreased interaction with free histones."; /evidence="ECO:0000269|PubMed:28334966"; MUTAGEN 51; /note="I->A,K: Impaired interaction with KAT7/HBO1."; /evidence="ECO:0000269|PubMed:28334966"; MUTAGEN 57; /note="L->A,K: Impaired interaction with KAT7/HBO1."; /evidence="ECO:0000269|PubMed:28334966"; MUTAGEN 59; /note="I->A,K: Impaired interaction with KAT7/HBO1."; /evidence="ECO:0000269|PubMed:28334966"; MUTAGEN 62..64; /note="EDD->AAA,KKK: Decreased interaction with free histones."; /evidence="ECO:0000269|PubMed:28334966
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
10602503
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
16387653
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18794358
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21720545
uniprot
proteins
pubmed
21753189
uniprot
proteins
pubmed
21880731
uniprot
proteins
pubmed
22464331
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25593309
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28334966
uniprot
proteins
pubmed
28584052
uniprot
proteins
pubmed
31827282
uniprot
proteins
sequence_length
1058
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21880731, ECO:0000269|PubMed:25593309}. Chromosome {ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:28334966}. Note=Localizes to transcription start sites. {ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:28334966}.
uniprot
proteins