SFRS3
entrez
6428
canonical
uniprot
P84103
canonical
ensembl
ENSG00000112081
resolver
ensp
ENSP00000362820
resolver
genesymbol
SFRS3
resolver
genesymbol
SRSF3
resolver
genesymbol_syn
SFRS3
resolver
genesymbol_syn
SRP20
resolver
hgnc
HGNC:10785
resolver
uniprot
B2R6F3
resolver
uniprot
B4E241
resolver
uniprot
O08831
resolver
uniprot
P23152
resolver
uniprot
Q5R3K0
resolver
uniprot_entry
B2R6F3_HUMAN
resolver
uniprot_entry
SRSF3_HUMAN
resolver
uniprot_sec
B4E241
resolver
uniprot_sec
O08831
resolver
uniprot_sec
P23152
resolver
uniprot_sec
Q5R3K0
resolver
amino_acid_sequence
MHRDSCPLDCKVYVGNLGNNGNKTELERAFGYYGPLRSVWVARNPPGFAFVEFEDPRDAADAVRELDGRTLCGCRVRVELSNGEKRSRNRGPPPSWGRRPRDDYRRRSPPPRRRSPRRRSFSRSRSRSLSRDRRRERSLSRERNHKPSRSFSRSRSRSRSNERK
uniprot
proteins
function
FUNCTION: Splicing factor, which binds the consensus motif 5'-C[ACU][AU]C[ACU][AC]C-3' within pre-mRNA and promotes specific exons inclusion during alternative splicing (PubMed:17036044, PubMed:26876937, PubMed:32440474). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites within exons (PubMed:26876937). Also functions as an adapter involved in mRNA nuclear export (PubMed:11336712, PubMed:18364396, PubMed:28984244). Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity (PubMed:11336712, PubMed:18364396). Involved in nuclear export of m6A-containing mRNAs via interaction with YTHDC1: interaction with YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export (PubMed:28984244). {ECO:0000269|PubMed:11336712, ECO:0000269|PubMed:17036044, ECO:0000269|PubMed:18364396, ECO:0000269|PubMed:26876937, ECO:0000269|PubMed:28984244, ECO:0000269|PubMed:32440474}.
uniprot
proteins
mass_dalton
19330
uniprot
proteins
mutagenesis
MUTAGEN 86; /note="R->E: Abolishes interaction with NXF1."; /evidence="ECO:0000269|PubMed:17036044"; MUTAGEN 88; /note="R->E: Abolishes interaction with NXF1."; /evidence="ECO:0000269|PubMed:17036044"; MUTAGEN 90; /note="R->E: Abolishes interaction with NXF1."; /evidence="ECO:0000269|PubMed:17036044
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CLK1, CLK2, CLK3 and CLK4. Extensively phosphorylated on serine residues in the RS domain. {ECO:0000250|UniProtKB:P84104}.
uniprot
proteins
protein_family
Splicing factor SR family
uniprot
proteins
pubmed
10757789
uniprot
proteins
pubmed
11336712
uniprot
proteins
pubmed
12667464
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15169763
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15595951
uniprot
proteins
pubmed
1577277
uniprot
proteins
pubmed
17036044
uniprot
proteins
pubmed
18364396
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26876937
uniprot
proteins
pubmed
28984244
uniprot
proteins
pubmed
32440474
uniprot
proteins
sequence_length
164
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11336712}. Nucleus speckle {ECO:0000269|PubMed:26876937}. Cytoplasm {ECO:0000269|PubMed:11336712}. Note=Recruited to nuclear speckles following interaction with YTHDC1. {ECO:0000269|PubMed:26876937}.
uniprot
proteins