Cyfip1
entrez
20430
canonical
uniprot
Q7TMB8
canonical
ensembl
ENSMUSG00000030447
resolver
ensp
ENSMUSP00000032629
resolver
ensp
ENSMUSP00000082353
resolver
ensp
ENSMUSP00000127717
resolver
ensp
ENSMUSP00000272671
resolver
enst
ENSMUST00000085255
resolver
genesymbol
Cyfip1
resolver
genesymbol_syn
Kiaa0068
resolver
genesymbol_syn
Shyc
resolver
genesymbol_syn
Sra1
resolver
uniprot
A0A0R4J119
resolver
uniprot
O88558
resolver
uniprot
Q3U7Q7
resolver
uniprot
Q5DU50
resolver
uniprot
Q7TSZ5
resolver
uniprot
Q80VN6
resolver
uniprot
Q8CE85
resolver
uniprot
Q99LY1
resolver
uniprot_entry
A0A0R4J119_MOUSE
resolver
uniprot_entry
CYFP1_MOUSE
resolver
uniprot_sec
O88558
resolver
uniprot_sec
Q3U7Q7
resolver
uniprot_sec
Q5DU50
resolver
uniprot_sec
Q7TSZ5
resolver
uniprot_sec
Q80VN6
resolver
uniprot_sec
Q8CE85
resolver
uniprot_sec
Q99LY1
resolver
amino_acid_sequence
MAAQVTLEDALSNVDLLEELPLPDQQPCIEPPPSSLLYQPNFNTNFEDRNAFVTGIARYIEQATVHSSMNEMLEEGQEYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMNFMYFQRNAIERFCGEVRRLCHAERRKDFVSEAYLITLGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNKITQSLQQQLEVISGYEELLADIVNLCVDYYENRMYLTPSEKHMLLKVMGFGLYLMDGSVSNIYKLDAKKRINLSKIDKYFKQLQVVPLFGDMQIELARYIKTSAHYEENKSRWTCASSSSSPQYNICEQMIQIREDHMRFISELARYSNSEVVTGSGRQEAQKTDAEYRKLFDLALQGLQLLSQWSAHVMEVYSWKLVHPTDKYSNKDCPDNAEEYERATRYNYTTEEKFALVEVIAMIKGLQVLMGRMESVFNHAIRHTVYAALQDFSQVTLREPLRQAIKKKKNVIQSVLQAIRKTVCDWETGHEPFNDPALRGEKDPKSGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLEGPTILDIEKFHRESFFYTHLINFSETLQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEASMMEYVLYSLDLYNDSAHYALTKFNKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKVMAGSLLLDKRLRSECKNQGATIHLPPSNRYETLLKQRHVQLLGRSIDLNRLITQRVSAAMYKSLELAIGRFESEDLTSVVELDGLLEINRMTHKLLSRYLTLDSFDAMFREANHNVSAPYGRITLHVFWELNYDFLPNYCYNGSTNRFVRTVLPFSQEFQRDKQPNAQPQYLHGSKALNLAYSSIYGSYRNFVGPPHFQVICRLLGYQGIAVVMEELLKVVKSLLQGTILQYVKTLMEVMPKICRLPRHEYGSPGILEFFHHQLKDIVEYAELKTVCFQNLREVGNAVLFCLLIEQSLSLEEVCDLLHAAPFQNILPRIHVKEGERVDAKMKRLESKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRTFLDDPIWRGPLPSNGVMHVDECVEFHRLWSAMQFVYCIPVGTHEFTVEQCFGDGLHWAGCMIIVLLGQQRRFAVLDFCYHLLKVQKHDGKDEIIKNVPLKKMVERIRKFQILNDEIITILDKYLKSGDGESTPVEHVRCFQPPIHQSLASS
uniprot
proteins
function
FUNCTION: Component of the CYFIP1-EIF4E-FMR1 complex which binds to the mRNA cap and mediates translational repression. In the CYFIP1-EIF4E-FMR1 complex this subunit is an adapter between EIF4E and FMR1. Promotes the translation repression activity of FMR1 in brain probably by mediating its association with EIF4E and mRNA (By similarity). Regulates formation of membrane ruffles and lamellipodia. Plays a role in axon outgrowth. Binds to F-actin but not to RNA. Part of the WAVE complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex. Actin remodeling activity is regulated by RAC1. Regulator of epithelial morphogenesis. May act as an invasion suppressor in cancers. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (PubMed:27605705). {ECO:0000250|UniProtKB:Q7L576, ECO:0000269|PubMed:11438699, ECO:0000269|PubMed:14765121, ECO:0000269|PubMed:18805096, ECO:0000269|PubMed:19524508, ECO:0000269|PubMed:27605705}.
uniprot
proteins
mass_dalton
145241
uniprot
proteins
mutagenesis
MUTAGEN 724; /note="D->A: EIF4E-binding reduced by 20%; when associated with A-726."; /evidence="ECO:0000269|PubMed:18805096"; MUTAGEN 724; /note="D->K: EIF4E-binding reduced by 60%; when associated with E-725, E-726 and K-730."; /evidence="ECO:0000269|PubMed:18805096"; MUTAGEN 725; /note="K->E: EIF4E-binding reduced by 70%. EIF4E-binding reduced by 60%; when associated with K-724, E-726 and K-730."; /evidence="ECO:0000269|PubMed:18805096"; MUTAGEN 726; /note="R->A: EIF4E-binding reduced by 20%; when associated with A-724."; /evidence="ECO:0000269|PubMed:18805096"; MUTAGEN 726; /note="R->E: EIF4E-binding reduced by 60%; when associated with K-724, E-725 and K-730."; /evidence="ECO:0000269|PubMed:18805096"; MUTAGEN 730; /note="E->K: EIF4E-binding reduced by 60%; when associated with K-724, E-725 and E-726."; /evidence="ECO:0000269|PubMed:18805096
uniprot
proteins
protein_family
CYFIP family
uniprot
proteins
pubmed
11438699
uniprot
proteins
pubmed
14765121
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18805096
uniprot
proteins
pubmed
19524508
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21946561
uniprot
proteins
pubmed
27605705
uniprot
proteins
pubmed
9756361
uniprot
proteins
sequence_length
1253
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11438699, ECO:0000269|PubMed:14765121}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11438699}. Cell projection, lamellipodium {ECO:0000269|PubMed:14765121}. Cell projection, ruffle {ECO:0000269|PubMed:14765121}. Synapse, synaptosome {ECO:0000269|PubMed:11438699}. Note=Highly expressed in the perinuclear region (PubMed:11438699). Enriched in synaptosomes (PubMed:11438699). Also enriched in membrane ruffles and at the tips of lamellipodia (PubMed:14765121). {ECO:0000269|PubMed:11438699, ECO:0000269|PubMed:14765121}.
uniprot
proteins