Hsph1
entrez
15505
canonical
uniprot
Q61699
canonical
ensembl
ENSMUSG00000029657
resolver
ensp
ENSMUSP00000074392
resolver
ensp
ENSMUSP00000144413
resolver
genesymbol
Hsph1
resolver
genesymbol_syn
Hsp105
resolver
genesymbol_syn
Hsp110
resolver
genesymbol_syn
Kiaa0201
resolver
uniprot
Q3TNS2
resolver
uniprot
Q3UIY8
resolver
uniprot
Q62578
resolver
uniprot
Q62579
resolver
uniprot
Q6A0A5
resolver
uniprot
Q8C430
resolver
uniprot
Q8VCW6
resolver
uniprot_entry
HS105_MOUSE
resolver
uniprot_sec
Q3TNS2
resolver
uniprot_sec
Q3UIY8
resolver
uniprot_sec
Q62578
resolver
uniprot_sec
Q62579
resolver
uniprot_sec
Q6A0A5
resolver
uniprot_sec
Q8C430
resolver
uniprot_sec
Q8VCW6
resolver
amino_acid_sequence
MSVVGLDVGSQSCYIAVARAGGIETIANEFSDRCTPSVISFGSKNRTIGVAAKNQQITHANNTVSSFKRFHGRAFNDPFIQKEKENLSYDLVPMKNGGVGIKVMYMDEEHFFSVEQITAMLLTKLKETAENNLKKPVTDCVISVPSFFTDAERRSVLDAAQIVGLNCLRLMNDMTAVALNYGIYKQDLPNAEEKPRVVVFVDMGHSSFQVSACAFNKGKLKVLGTAFDPFLGGKNFDEKLVEHFCAEFKTKYKLDAKSKIRALLRLHQECEKLKKLMSSNSTDLPLNIECFMNDKDVSGKMNRSQFEELCAELLQKIEVPLHSLMAQTQLKAEDVSAIEIVGGATRIPAVKERIAKFFGKDVSTTLNADEAVARGCALQCAILSPAFKVREFSVTDAVPFPISLVWNHDSEETEGVHEVFSRNHAAPFSKVLTFLRRGPFELEAFYSDPQGVPYPEAKIGRFVVQNVSAQKDGEKSRVKVKVRVNTHGIFTISTASMVEKVPTEEEDGSSLEADMECPNQRPTESSDVDKNIQQDNSEAGTQPQVQTDGQQTSQSPPSPELTSEESKTPDADKANEKKVDQPPEAKKPKIKVVNVELPVEANLVWQLGRDLLNMYIETEGKMIMQDKLEKERNDAKNAVEECVYEFRDKLCGPYEKFICEQEHEKFLRLLTETEDWLYEEGEDQAKQAYIDKLEELMKMGTPVKVRFQEAEERPKVLEELGQRLQHYAKIAADFRGKDEKYNHIDESEMKKVEKSVNEVMEWMNNVMNAQAKRSLDQDPVVRTHEIRAKVKELNNVCEPVVTQPKPKIESPKLERTPNGPNIDKKEDLEGKNNLGAEAPHQNGECHPNEKGSVNMDLD
uniprot
proteins
function
FUNCTION: Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (By similarity). Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (PubMed:14644449, PubMed:15292236). {ECO:0000250|UniProtKB:Q92598, ECO:0000269|PubMed:14644449, ECO:0000269|PubMed:15292236}.
uniprot
proteins
mass_dalton
96407
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity. {ECO:0000269|PubMed:10772927, ECO:0000269|PubMed:12558502}.
uniprot
proteins
protein_family
Heat shock protein 70 family
uniprot
proteins
pubmed
10066425
uniprot
proteins
pubmed
10772927
uniprot
proteins
pubmed
10865058
uniprot
proteins
pubmed
12558502
uniprot
proteins
pubmed
14644449
uniprot
proteins
pubmed
15292236
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16232202
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
7556594
uniprot
proteins
pubmed
8530361
uniprot
proteins
pubmed
9675148
uniprot
proteins
sequence_length
858
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10865058}. Nucleus {ECO:0000269|PubMed:10865058}. Note=Strictly cytoplasmic in neurons.
uniprot
proteins