SH3KBP1
entrez
30011
canonical
uniprot
Q96B97
canonical
ensembl
ENSG00000147010
resolver
ensp
ENSP00000369039
resolver
ensp
ENSP00000369049
resolver
ensp
ENSP00000380921
resolver
ensp
ENSP00000514511
resolver
ensp
ENSP00000514513
resolver
ensp
ENSP00000514514
resolver
ensp
ENSP00000514516
resolver
ensp
ENSP00000514517
resolver
ensp
ENSP00000514544
resolver
ensp
ENSP00000514545
resolver
ensp
ENSP00000514547
resolver
ensp
ENSP00000514549
resolver
ensp
ENSP00000514555
resolver
ensp
ENSP00000514710
resolver
ensp
ENSP00000514711
resolver
ensp
ENSP00000514712
resolver
ensp
ENSP00000514713
resolver
enst
ENST00000379726
resolver
enst
ENST00000699668
resolver
enst
ENST00000699670
resolver
enst
ENST00000699671
resolver
enst
ENST00000699673
resolver
enst
ENST00000699674
resolver
enst
ENST00000699720
resolver
enst
ENST00000699721
resolver
enst
ENST00000699725
resolver
enst
ENST00000699726
resolver
enst
ENST00000699729
resolver
enst
ENST00000699732
resolver
enst
ENST00000699733
resolver
enst
ENST00000699738
resolver
genesymbol
SH3KBP1
resolver
genesymbol_syn
CIN85
resolver
hgnc
HGNC:13867
resolver
uniprot
A0A8V8TNL0
resolver
uniprot
A0A8V8TNT5
resolver
uniprot
A0A8V8TNW8
resolver
uniprot
A0A8V8TP27
resolver
uniprot
A0A8V8TP33
resolver
uniprot
A0A8V8TP40
resolver
uniprot
A0A8V8TP63
resolver
uniprot
A0A8V8TP69
resolver
uniprot
A0A8V8TPM1
resolver
uniprot
A0A8V8TQF6
resolver
uniprot
A0A8V8TQU1
resolver
uniprot
B7Z1D5
resolver
uniprot
B7Z6E8
resolver
uniprot
Q5JPT2
resolver
uniprot
Q5JPT4
resolver
uniprot
Q5JPT5
resolver
uniprot
Q5JPT6
resolver
uniprot
Q8IWX6
resolver
uniprot
Q8IX98
resolver
uniprot
Q96RN4
resolver
uniprot
Q9NYR0
resolver
uniprot_entry
A0A8V8TNL0_HUMAN
resolver
uniprot_entry
A0A8V8TNT5_HUMAN
resolver
uniprot_entry
A0A8V8TNW8_HUMAN
resolver
uniprot_entry
A0A8V8TP27_HUMAN
resolver
uniprot_entry
A0A8V8TP33_HUMAN
resolver
uniprot_entry
A0A8V8TP40_HUMAN
resolver
uniprot_entry
A0A8V8TP63_HUMAN
resolver
uniprot_entry
A0A8V8TP69_HUMAN
resolver
uniprot_entry
A0A8V8TPM1_HUMAN
resolver
uniprot_entry
A0A8V8TQF6_HUMAN
resolver
uniprot_entry
A0A8V8TQU1_HUMAN
resolver
uniprot_entry
B7Z6E8_HUMAN
resolver
uniprot_entry
Q5JPT2_HUMAN
resolver
uniprot_entry
Q5JPT6_HUMAN
resolver
uniprot_entry
SH3K1_HUMAN
resolver
uniprot_sec
B7Z1D5
resolver
uniprot_sec
Q5JPT4
resolver
uniprot_sec
Q5JPT5
resolver
uniprot_sec
Q8IWX6
resolver
uniprot_sec
Q8IX98
resolver
uniprot_sec
Q96RN4
resolver
uniprot_sec
Q9NYR0
resolver
amino_acid_sequence
MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREIKKEMKKDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEKEGNRPKKPPPPSAPVIKQGAGTTERKHEIKKIPPERPEMLPNRTEEKERPEREPKLDLQKPSVPAIPPKKPRPPKTNSLSRPGALPPRRPERPVGPLTHTRGDSPKIDLAGSSLSGILDKDLSDRSNDIDLEGFDSVVSSTEKLSHPTTSRPKATGRRPPSQSLTSSSLSSPDIFDSPSPEEDKEEHISLAHRGVDASKKTSKTVTISQVSDNKASLPPKPGTMAAGGGGPAPLSSAAPSPLSSSLGTAGHRANSPSLFGTEGKPKMEPAASSQAAVEELRTQVRELRSIIETMKDQQKREIKQLLSELDEEKKIRLRLQMEVNDIKKALQSK
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency 61 (IMD61) [MIM:300310]: An X-linked recessive primary immunologic disorder characterized by recurrent infections due to impaired antibody production. Affected individuals have normal numbers of circulating B and T cells, but B cells have an intrinsic defect in antibody production. Disease severity is variable and onset is in early childhood. {ECO:0000269|PubMed:29636373}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation (PubMed:29636373). {ECO:0000250, ECO:0000269|PubMed:11894095, ECO:0000269|PubMed:11894096, ECO:0000269|PubMed:12177062, ECO:0000269|PubMed:12734385, ECO:0000269|PubMed:12771190, ECO:0000269|PubMed:15090612, ECO:0000269|PubMed:15707590, ECO:0000269|PubMed:16177060, ECO:0000269|PubMed:16256071, ECO:0000269|PubMed:21275903, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:29636373}.
uniprot
proteins
mass_dalton
73126
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated by CBL and CBLB after EGF stimulation; probably on its C-terminus.
uniprot
proteins
pubmed
10679202
uniprot
proteins
pubmed
11071869
uniprot
proteins
pubmed
11474197
uniprot
proteins
pubmed
11894095
uniprot
proteins
pubmed
11894096
uniprot
proteins
pubmed
12177062
uniprot
proteins
pubmed
12218189
uniprot
proteins
pubmed
12618476
uniprot
proteins
pubmed
12690097
uniprot
proteins
pubmed
12734385
uniprot
proteins
pubmed
12771190
uniprot
proteins
pubmed
14596919
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15090612
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15456872
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15707590
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
15962011
uniprot
proteins
pubmed
16177060
uniprot
proteins
pubmed
16228008
uniprot
proteins
pubmed
16256071
uniprot
proteins
pubmed
16678097
uniprot
proteins
pubmed
16751601
uniprot
proteins
pubmed
16895919
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20221403
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21275903
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21834987
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29636373
uniprot
proteins
pubmed
31493651
uniprot
proteins
pubmed
39390519
uniprot
proteins
sequence_length
665
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20221403}. Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Peripheral membrane protein. Synapse, synaptosome. Cell junction, focal adhesion {ECO:0000250}. Note=Localized in endocytic vesicles containing clustered receptors. Colocalizes with ASAP1 in vesicular structures. Colocalized with actin microfilaments and focal adhesions (By similarity). Colocalized with MAGI2 in synaptosomes. Translocation to EGFR containing vesicles upon EGF stimulation is inhibited in the presence of SH3KBP1 (By similarity). Colocalizes with ZFP36 in the cytoplasm (PubMed:20221403). {ECO:0000250|UniProtKB:Q8R550, ECO:0000269|PubMed:20221403}.
uniprot
proteins