Calcr
entrez
12311
canonical
uniprot
Q60755
canonical
ensembl
ENSMUSG00000023964
resolver
ensp
ENSMUSP00000075070
resolver
ensp
ENSMUSP00000111285
resolver
ensp
ENSMUSP00000130083
resolver
ensp
ENSMUSP00000132124
resolver
genesymbol
Calcr
resolver
uniprot
F6X7J4
resolver
uniprot
Q3UUL9
resolver
uniprot
Q8CAB0
resolver
uniprot_entry
CALCR_MOUSE
resolver
uniprot_sec
F6X7J4
resolver
uniprot_sec
Q3UUL9
resolver
uniprot_sec
Q8CAB0
resolver
amino_acid_sequence
MTPRRSRVKRRNLRKPKMRFLLVNRFTLLLLLLVSPTPVLQAPTNLTDSGLDQEPFLYLVGRKKLLDAQYKCYDRIHQLPSYEGEGLYCNRTWDGWMCWDDTPAGATAYQHCPDYFPDFDTAEKVSKYCDENGEWFRHPDSNRTWSNYTLCNAFTSEKLQNAYVLYYLALVGHSLSIAALVASMLIFWIFKNLSCQRVTLHKHMFLTYILNSIIIIIHLVEVVPNGDLVRRDPMHIFHHNTHMWTMQWELSPPLPLSAHEGKMDPHASEVISCKVLHFLHQYMMSCNYFWMLCEGIYLHTLIVMAVFTDEQRLRWYYLLGWGFPIVPTIIHAITRALYYNDNCWLSAETHLLYIIHGPVMVALVVNFFFLLNIVRVLVTKMRQTHEAESYMYLKAVKATMVLVPLLGIQFVVFPWRPSNKVLGKIYDYLMHSLIHFQGFFVATIYCFCNHEVQVTLKRQWTQFKIQWSQRWGRRRRPTNRVVSAPRAVAFAEPDGLPIYICHQEPRNPPISNNEGEESTEMIPMNVIQQDASA
uniprot
proteins
function
FUNCTION: G protein-coupled receptor activated by ligand peptides amylin (IAPP), calcitonin (CT/CALCA) and calcitonin gene-related peptide type 1 (CGRP1/CALCA). CALCR interacts with receptor-activity-modifying proteins RAMP1, 2 and 3 to form receptor complexes AMYR1, 2 and 3, respectively. IAPP, CT and CGRP1 activate CALCR and AMYRs with distinct modes of receptor activation resulting in specific phenotypes. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. {ECO:0000250|UniProtKB:P30988}.
uniprot
proteins
mass_dalton
62469
uniprot
proteins
protein_family
G protein-coupled receptor 2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
7988453
uniprot
proteins
sequence_length
533
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P30988}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P30988}.
uniprot
proteins
transmembrane_region
TRANSMEM 164..186; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P30988"; TRANSMEM 199..219; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P30988"; TRANSMEM 274..296; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P30988"; TRANSMEM 314..334; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P30988"; TRANSMEM 351..374; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P30988"; TRANSMEM 395..413; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P30988"; TRANSMEM 422..448; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P30988
uniprot
proteins