Psma6
entrez
29673
canonical
uniprot
P60901
canonical
ensembl
ENSRNOG00000007114
resolver
ensembl
ENSRNOG00055013444
resolver
ensembl
ENSRNOG00060020304
resolver
ensembl
ENSRNOG00065005071
resolver
ensp
ENSRNOP00000009666
resolver
ensp
ENSRNOP00000071403
resolver
ensp
ENSRNOP00055018686
resolver
ensp
ENSRNOP00060028969
resolver
ensp
ENSRNOP00065005177
resolver
enst
ENSRNOT00055023043
resolver
enst
ENSRNOT00060035234
resolver
enst
ENSRNOT00065007447
resolver
genesymbol
Psma6
resolver
uniprot
P34062
resolver
uniprot_entry
PSA6_RAT
resolver
uniprot_sec
P34062
resolver
amino_acid_sequence
MSRGSSAGFDRHITIFSPEGRLYQVEYAFKAINQGGLTSVAVRGKDCAVIVTQKKVPDKLLDSSTVTHLFKITENIGCVMTGMTADSRSQVQRARYEAANWKYKYGYEIPVDMLCKRIADISQVYTQNAEMRPLGCCMILIGIDEEQGPQVYKCDPAGYYCGFKATAAGVKQTESTSFLEKKVKKKFDWTFEQTVETAITCLSTVLSIDFKPSEIEVGVVTVENPKFRILTEAEIDAHLVALAERD
uniprot
proteins
function
FUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000250|UniProtKB:P60900}.
uniprot
proteins
mass_dalton
27399
uniprot
proteins
protein_family
Peptidase T1A family
uniprot
proteins
pubmed
1491007
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
246
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P60900, ECO:0000250|UniProtKB:Q9QUM9}. Nucleus {ECO:0000250|UniProtKB:P60900}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9 (By similarity). Colocalizes with TRIM5 in cytoplasmic bodies (By similarity). {ECO:0000250|UniProtKB:P60900, ECO:0000250|UniProtKB:Q9QUM9}.
uniprot
proteins