Cacnb2
entrez
12296
canonical
uniprot
Q8CC27
canonical
ensembl
ENSMUSG00000057914
resolver
ensp
ENSMUSP00000110367
resolver
ensp
ENSMUSP00000110371
resolver
ensp
ENSMUSP00000141221
resolver
enst
ENSMUST00000193800
resolver
genesymbol
Cacnb2
resolver
genesymbol_syn
CACNB2
resolver
genesymbol_syn
CacnB2
resolver
genesymbol_syn
Cacnlb2
resolver
uniprot
A0A0A6YVQ8
resolver
uniprot
A0A0A7NQN9
resolver
uniprot
A2ASJ8
resolver
uniprot
C7IVS7
resolver
uniprot
Q32MF3
resolver
uniprot
Q8C5J5
resolver
uniprot
Q9CTQ6
resolver
uniprot_entry
A0A0A6YVQ8_MOUSE
resolver
uniprot_entry
A0A0A7NQN9_MOUSE
resolver
uniprot_entry
C7IVS7_MOUSE
resolver
uniprot_entry
CACB2_MOUSE
resolver
uniprot_entry
Q32MF3_MOUSE
resolver
uniprot_sec
A2ASJ8
resolver
uniprot_sec
Q8C5J5
resolver
uniprot_sec
Q9CTQ6
resolver
amino_acid_sequence
MVQSDTSKSPPVAAVAQESQMELLESAAPAGALGAQSYGKGARRKNRFKGSDGSTSSDTTSNSFVRQGSADSYTSRPSDSDVSLEEDREAVRREAERQAQAQLEKAKTKPVAFAVRTNVRYSAAQEDDVPVPGMAISFEAKDFLHVKEKFNNDWWIGRLVKEGCEIGFIPSPVKLENMRLQHEQRAKQGKFYSSKSGGNSSSSLGDIVPSSRKSTPPSSAIDIDATGLDAEENDIPANHRSPKPSANSVTSPHSKEKRMPFFKKTEHTPPYDVVPSMRPVVLVGPSLKGYEVTDMMQKALFDFLKHRFEGRISITRVTADISLAKRSVLNNPSKHAIIERSNTRSSLAEVQSEIERIFELARTLQLVVLDADTINHPAQLSKTSLAPIIVYVKISSPKVLQRLIKSRGKSQAKHLNVQMVAADKLAQCPPQESFDVILDENQLEDACEHLADYLEAYWKATHPPSGNLPNPLLSRTLASSTLPLSPTLASNSQGSQGDQRPDRSAPRSASQAEEEPCLEPVKKSQHRSSSATHQNHRSGTGRGLSRQETFDSETQESRDSAYVEPKEDYSHEHVDRYVPHREHNHREETHSSNGHRHRESRHRSRDMGRDQDHNECIKQRSRHKSKDRYCDKEGEVISKRRNEAGEWNRDVYIRQ
uniprot
proteins
function
FUNCTION: Beta subunit of voltage-dependent calcium channels which contributes to the function of the calcium channel by increasing peak calcium current (PubMed:14674701, PubMed:36424916). Plays a role in shifting voltage dependencies of activation and inactivation of the channel (By similarity). May modulate G protein inhibition (By similarity). May contribute to beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force (PubMed:36424916). Involved in membrane targeting of the alpha-1 subunit CACNA1C (By similarity). {ECO:0000250|UniProtKB:Q08289, ECO:0000250|UniProtKB:Q8VGC3, ECO:0000269|PubMed:14674701, ECO:0000269|PubMed:36424916}.
uniprot
proteins
mass_dalton
73149
uniprot
proteins
mutagenesis
MUTAGEN 370..372; /note="DAD->AAA: Reduces binding to RRAD."; /evidence="ECO:0000269|PubMed:36424916
uniprot
proteins
post_translational_modification
PTM: Regulated through phosphorylation at Thr-549 by CaMK2D. {ECO:0000250}.
uniprot
proteins
protein_family
Calcium channel beta subunit family
uniprot
proteins
pubmed
14674701
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24751537
uniprot
proteins
pubmed
36424916
uniprot
proteins
sequence_length
655
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
uniprot
proteins