Rchy1
entrez
68098
canonical
uniprot
Q9CR50
canonical
ensembl
ENSMUSG00000029397
resolver
ensp
ENSMUSP00000031345
resolver
ensp
ENSMUSP00000131270
resolver
enst
ENSMUST00000031345
resolver
enst
ENSMUST00000169948
resolver
genesymbol
Rchy1
resolver
genesymbol_syn
Arnip
resolver
genesymbol_syn
Chimp
resolver
genesymbol_syn
Zfp363
resolver
genesymbol_syn
Znf363
resolver
uniprot
G3UWD8
resolver
uniprot
Q920H0
resolver
uniprot_entry
G3UWD8_MOUSE
resolver
uniprot_entry
ZN363_MOUSE
resolver
uniprot_sec
Q920H0
resolver
amino_acid_sequence
MAATAREDGVRNLAQGPRGCEHYDRACLLKAPCCDKLYTCRLCHDTNEDHQLDRFKVKEVQCINCEKLQHAQQTCEDCSTLFGEYYCSICHLFDKDKRQYHCESCGICRIGPKEDFFHCLKCNLCLTTNLRGKHKCIENVSRQNCPICLEDIHTSRVVAHVLPCGHLLHRTCYEEMLKEGYRCPLCMHSALDMTRYWRQLDTEVAQTPMPSEYQNVTVDILCNDCNGRSTVQFHILGMKCKLCDSYNTAQAGGRRVPVDQQ
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins, including p53/TP53, TP73, HDAC1 and CDKN1B (By similarity). Mediates ubiquitination and degradation of p53/TP53; preferentially acts on tetrameric p53/TP53 (By similarity). Catalyzes monoubiquitinates the translesion DNA polymerase POLH (PubMed:12654245). Involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: RCHY1 acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation (By similarity). {ECO:0000250|UniProtKB:Q96PM5, ECO:0000269|PubMed:12654245}.
uniprot
proteins
mass_dalton
30014
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q96PM5}.
uniprot
proteins
post_translational_modification
PTM: Subject to ubiquitination and proteasomal degradation. Interaction with PLAGL2 or KAT5 enhances protein stability. {ECO:0000250|UniProtKB:Q96PM5}.
uniprot
proteins
pubmed
12654245
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
261
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96PM5}. Nucleus speckle {ECO:0000250|UniProtKB:Q96PM5}. Cytoplasm {ECO:0000250|UniProtKB:Q96PM5}.
uniprot
proteins