Cops4
entrez
26891
canonical
uniprot
O88544
canonical
ensembl
ENSMUSG00000035297
resolver
ensp
ENSMUSP00000048416
resolver
ensp
ENSMUSP00000114585
resolver
ensp
ENSMUSP00000185274
resolver
ensp
ENSMUSP00000185276
resolver
ensp
ENSMUSP00000185280
resolver
enst
ENSMUST00000045993
resolver
genesymbol
Cops4
resolver
genesymbol_syn
Csn4
resolver
uniprot
Q14AI7
resolver
uniprot_entry
CSN4_MOUSE
resolver
uniprot_entry
Q14AI7_MOUSE
resolver
amino_acid_sequence
MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGTEQLEALKAFVEAMVNENVSLVISRQLLTDFCTHLPNLPDSTAKEVYHFTLEKIQPRVISFEEQVASIRQHLASIYEKEEDWRNAAQVLVGIPLETGQKQYNVDYKLETYLKIARLYLEDDDPVQAEAYINRASLLQNESTNEQLQIHYKVCYARVLDYRRKFIEAAQRYNELSYKTIVHESERLEALKHALHCTILASAGQQRSRMLATLFKDERCQQLAAYGILEKMYLDRIIRGNQLQEFAAMLMPHQKATTADGSSILDRAVIEHNLLSASKLYNNITFEELGALLEIPAAKAEKIASQMITEGRMNGFIDQIDGIVHFETREALPTWDKQIQSLCFQVNNLLEKISQTAPEWTAQAMEAQMAQ
uniprot
proteins
function
FUNCTION: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). Also involved in the deneddylation of non-cullin subunits such as STON2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP and SNAPIN, possibly via its association with CK2 and PKD kinases (By similarity). CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). {ECO:0000250|UniProtKB:Q9BT78}.
uniprot
proteins
mass_dalton
46285
uniprot
proteins
protein_family
CSN4 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9707402
uniprot
proteins
sequence_length
406
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BT78}. Nucleus {ECO:0000250|UniProtKB:Q9BT78}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:Q9BT78}.
uniprot
proteins