DEFB114
entrez
245928
canonical
uniprot
Q30KQ6
canonical
ensembl
ENSG00000177684
resolver
ensp
ENSP00000312702
resolver
enst
ENST00000322066
resolver
genesymbol
DEFB114
resolver
genesymbol_syn
DEFB14
resolver
hgnc
HGNC:18095
resolver
uniprot
Q8NES9
resolver
uniprot_entry
DB114_HUMAN
resolver
uniprot_sec
Q8NES9
resolver
amino_acid_sequence
MRIFYYLHFLCYVTFILPATCTLVNADRCTKRYGRCKRDCLESEKQIDICSLPRKICCTEKLYEEDDMF
uniprot
proteins
function
FUNCTION: Has a salt-sensitive antimicrobial activity against Gram-negative bacteria, including E.coli, Gram-positive, including S.aureus, and fungi, including C.albicans. Binds to and neutralizes bacterial lipopolysaccharides (LPS), abolishing TNF production by macrophages challenged with LPS. Rescues the LPS-induced reduction of sperm motility in vitro and may protect from LPS-induced lethality. {ECO:0000269|PubMed:23482568}.
uniprot
proteins
mass_dalton
8318
uniprot
proteins
protein_family
Beta-defensin family
uniprot
proteins
pubmed
11854508
uniprot
proteins
pubmed
16033865
uniprot
proteins
pubmed
23482568
uniprot
proteins
sequence_length
69
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
uniprot
proteins