Tprn
entrez
97031
canonical
uniprot
A2AI08
canonical
ensembl
ENSMUSG00000048707
resolver
ensp
ENSMUSP00000109975
resolver
enst
ENSMUST00000114336
resolver
genesymbol
Tprn
resolver
uniprot
Q3TAJ8
resolver
uniprot
Q3TMR8
resolver
uniprot
Q5FWB3
resolver
uniprot
Q7TNG3
resolver
uniprot
Q8BNM5
resolver
uniprot
Q8R1G4
resolver
uniprot_entry
TPRN_MOUSE
resolver
uniprot_sec
Q3TAJ8
resolver
uniprot_sec
Q3TMR8
resolver
uniprot_sec
Q5FWB3
resolver
uniprot_sec
Q7TNG3
resolver
uniprot_sec
Q8BNM5
resolver
uniprot_sec
Q8R1G4
resolver
amino_acid_sequence
MAGLGRLDPGPRTVMPAWKREILERRRAKLAALSGGQGSGAAPDGPNERLVLAESLGPLSQNPFMRLESERRRGTRPAQQLLELYCRVPGVRTIRADNILIIESAPGFPPAVPPAAGIRAAEVVVYEAPQPGRVSRLLEKFDSPAAPCRRGSPERFRPALPQLPVASASAATRTPTNRSLAPASPVRLSQPAPPISPVPVAQRAGQRSACCEPAHPDGTAGPGARRSDFLQKTGSNSFTVHPRGLPRSAVNRSLSNGPMTQESPTGPANGLSGSPPVPGKWKPKVESKEPSLHPPPSPGTPSATSVGPPAFPAPSPASATPSQRQWVSSATSANDSFEIRPSSKPDMETIPIGDLQARALANLRVNSRNSFVLIPKRKAPGNYPLAGRQFEEPKGEVGWASQSQGLGSQLVSTVDGAPALEKSPLAAEMQWAVRKGACPRPAISDTDKCVRWQRPASPPPFLPATAEAEPAEGLGVPGLAKNGQEPVRPGLPVTFIDEVDSEEEAFQEAKLPSSAVGVPSQYHLHPARPGHTSELLNRGSNTFTVVPKRKPGTLQEPHLSQTNGQSQQGAEEQDAESLSGPHTTLENTLKKRYPTVHEIEVIGGYLALQKSCLIKAGSSRKKMKISFNDKSLHTTFEYPSESSLAQEEAEEEEEEEGEEDGEEEEVGPDSEKPFTVFLPRATFVSSVGPESSSGLSSYTPKHSMAFSKWQEQTLVQTPTDVELPPKEVMLTPASQNDLSDFRSEPALYF
uniprot
proteins
function
FUNCTION: Essential for hearing (PubMed:30380417, PubMed:35752427, PubMed:37952086). Required for maintenance of stereocilia on both inner and outer hair cells (PubMed:27693694). Necessary for the integrity of the stereociliary rootlet (PubMed:30159668). May act as an actin cytoskeleton regulator involved in the regulation of actin dynamics at the pointed end in hair cells (PubMed:30380417). Forms rings at the base of stereocilia and binds actin filaments in the stereocilia which may stabilize the stereocilia (PubMed:37952086). Acts as a strong inhibitor of PPP1CA phosphatase activity (By similarity). Recruited to sites of DNA damage and may play a role in DNA damage repair (By similarity). {ECO:0000250|UniProtKB:Q4KMQ1, ECO:0000269|PubMed:27693694, ECO:0000269|PubMed:30159668, ECO:0000269|PubMed:30380417, ECO:0000269|PubMed:35752427, ECO:0000269|PubMed:37952086}.
uniprot
proteins
mass_dalton
80089
uniprot
proteins
protein_family
Taperin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20170898
uniprot
proteins
pubmed
20170899
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24285636
uniprot
proteins
pubmed
27693694
uniprot
proteins
pubmed
30159668
uniprot
proteins
pubmed
30380417
uniprot
proteins
pubmed
35752427
uniprot
proteins
pubmed
37952086
uniprot
proteins
sequence_length
749
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, stereocilium {ECO:0000269|PubMed:20170899, ECO:0000269|PubMed:24285636, ECO:0000269|PubMed:30159668, ECO:0000269|PubMed:30380417, ECO:0000269|PubMed:35752427, ECO:0000269|PubMed:37952086}. Cell projection, microvillus {ECO:0000269|PubMed:24285636}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q4KMQ1}. Cytoplasm {ECO:0000250|UniProtKB:Q4KMQ1}. Note=Localized prominently at the basal taper region of hair cell stereocilia (PubMed:20170899, PubMed:30159668, PubMed:30380417, PubMed:37952086). Forms organized ring-like structures with diameters ranging from 150 to 200 nm in the stereocilium taper region (PubMed:37952086). Detected in microvilli of inner hair cell supporting cells (PubMed:24285636). Predominantly nuclear in non-stereocilium cells but can shuttle between the nucleus and the cytoplasm (By similarity). {ECO:0000250|UniProtKB:Q4KMQ1, ECO:0000269|PubMed:20170899, ECO:0000269|PubMed:24285636, ECO:0000269|PubMed:30159668, ECO:0000269|PubMed:30380417, ECO:0000269|PubMed:37952086}.
uniprot
proteins