Fmo5
entrez
246248
canonical
uniprot
Q8K4C0
canonical
ensembl
ENSRNOG00000018076
resolver
ensp
ENSRNOP00000024423
resolver
ensp
ENSRNOP00000108959
resolver
enst
ENSRNOT00000024423
resolver
genesymbol
Fmo5
resolver
uniprot
A0A0G2JSQ2
resolver
uniprot
Q6IRL0
resolver
uniprot_entry
A0A0G2JSQ2_RAT
resolver
uniprot_entry
FMO5_RAT
resolver
uniprot_sec
Q6IRL0
resolver
amino_acid_sequence
MAKKRIAVIGSGASGLTCIKCCLEEGLEPVCFERSDDIGGLWRYQENPEKGRASIYKSVIINTSKEMMCFSDYPIPDHYPNFMHNSQVLEYFRMYAKEFGLLKYIQFKTTVCSVKKQPDFSTSGQWQVVTEHEGKQQVDVFDGVLVCTGHHTDPHLPLDSFPGIEKFKGKYFHSREYKNPVEFTGKRVIVIGIGNSGGDLAVEISHTAKQVFLSTRRGAWILNRVGKRGYPIDILLSSRITNYLSKICGSALKNRYMEKQLNQRFDHEMFGLKPKHSALGQHPTINDDLPNRIISGLVKVKGNVKEFTETAAIFEDGSREDDIDVVIFATGYSFAFPFLEDSVKVVQNKVSLYKKVFPPNLEKPTLAIIGLIQPLGAIMPISELQGRWATQVFKGLKKLPSQSEMMAEINKTREEMAKRYVDSQRHTIQGDYIDTMEEIADLVGVRPNLLSLAFTDPKLAFQLLVGPCTPVQYRLQGPGKWAGARKTILTTEDRIRKPLMTRVVERDSSGTSLVTVRVLMLAVTFLAVILAYF
uniprot
proteins
ec_number
1.14.13.8
uniprot
proteins
ec_number
1.6.3.1
uniprot
proteins
function
FUNCTION: Acts as a Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Active on diverse carbonyl compounds, whereas soft nucleophiles are mostly non- or poorly reactive. In contrast with other forms of FMO it is non- or poorly active on 'classical' substrates such as drugs, pesticides, and dietary components containing soft nucleophilic heteroatoms. Able to oxidize drug molecules bearing a carbonyl group on an aliphatic chain, such as nabumetone and pentoxifylline. Also, in the absence of substrates, shows slow but yet significant NADPH oxidase activity (By similarity). Acts as a positive modulator of cholesterol biosynthesis as well as glucose homeostasis, promoting metabolic aging via pleiotropic effects (By similarity). {ECO:0000250|UniProtKB:P49326, ECO:0000250|UniProtKB:P97872}.
uniprot
proteins
mass_dalton
60056
uniprot
proteins
protein_family
FMO family
uniprot
proteins
pubmed
15047867
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
533
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000250|UniProtKB:P49326}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P49326}.
uniprot
proteins
transmembrane_region
TRANSMEM 513..533; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins