Apoe
entrez
11816
canonical
uniprot
P08226
canonical
ensembl
ENSMUSG00000002985
resolver
ensp
ENSMUSP00000003066
resolver
ensp
ENSMUSP00000133302
resolver
ensp
ENSMUSP00000133371
resolver
ensp
ENSMUSP00000134160
resolver
ensp
ENSMUSP00000360810
resolver
enst
ENSMUST00000003066
resolver
enst
ENSMUST00000173739
resolver
enst
ENSMUST00000174064
resolver
enst
ENSMUST00000174355
resolver
genesymbol
Apoe
resolver
uniprot
Q3TXU4
resolver
uniprot_entry
APOE_MOUSE
resolver
uniprot_entry
Q3TXU4_MOUSE
resolver
amino_acid_sequence
MKALWAVLLVTLLTGCLAEGEPEVTDQLEWQSNQPWEQALNRFWDYLRWVQTLSDQVQEELQSSQVTQELTALMEDTMTEVKAYKKELEEQLGPVAEETRARLGKEVQAAQARLGADMEDLRNRLGQYRNEVHTMLGQSTEEIRARLSTHLRKMRKRLMRDAEDLQKRLAVYKAGAREGAERGVSAIRERLGPLVEQGRQRTANLGAGAAQPLRDRAQAFGDRIRGRLEEVGNQARDRLEEVREHMEEVRSKMEEQTQQIRLQAEIFQARLKGWFEPIVEDMHRQWANLMEKIQASVATNPIITPVAQENQ
uniprot
proteins
function
FUNCTION: APOE is an apolipoprotein, a protein associating with lipid particles, that mainly functions in lipoprotein-mediated lipid transport between organs via the plasma and interstitial fluids. APOE is a core component of plasma lipoproteins and is involved in their production, conversion and clearance. Apolipoproteins are amphipathic molecules that interact both with lipids of the lipoprotein particle core and the aqueous environment of the plasma. As such, APOE associates with chylomicrons, chylomicron remnants, very low density lipoproteins (VLDL) and intermediate density lipoproteins (IDL) but shows a preferential binding to high-density lipoproteins (HDL). It also binds a wide range of cellular receptors including the LDL receptor/LDLR and the very low-density lipoprotein receptor/VLDLR that mediate the cellular uptake of the APOE-containing lipoprotein particles (By similarity). Finally, APOE also has a heparin-binding activity and binds heparan-sulfate proteoglycans on the surface of cells, a property that supports the capture and the receptor-mediated uptake of APOE-containing lipoproteins by cells (PubMed:23676495). {ECO:0000250|UniProtKB:P02649, ECO:0000269|PubMed:23676495}.
uniprot
proteins
mass_dalton
35867
uniprot
proteins
post_translational_modification
PTM: APOE exists as multiple glycosylated and sialylated glycoforms within cells and in plasma. The extent of glycosylation and sialylation are tissue and context specific. {ECO:0000269|PubMed:29516132}.; PTM: Glycated in plasma VLDL. {ECO:0000250|UniProtKB:P02649}.; PTM: Phosphorylated by FAM20C in the extracellular medium. {ECO:0000250|UniProtKB:P02649}.
uniprot
proteins
protein_family
Apolipoprotein A1/A4/E family
uniprot
proteins
pubmed
12569158
uniprot
proteins
pubmed
1423598
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16876491
uniprot
proteins
pubmed
1870200
uniprot
proteins
pubmed
20037584
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23676495
uniprot
proteins
pubmed
23812099
uniprot
proteins
pubmed
2550421
uniprot
proteins
pubmed
26387950
uniprot
proteins
pubmed
29516132
uniprot
proteins
pubmed
3865219
uniprot
proteins
sequence_length
311
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02649}. Secreted, extracellular space {ECO:0000250|UniProtKB:P02649}. Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P02649}. Extracellular vesicle {ECO:0000250|UniProtKB:P02649}. Endosome, multivesicular body {ECO:0000250|UniProtKB:P02649}. Note=In the plasma, APOE is associated with chylomicrons, chylomicrons remnants, VLDL, LDL and HDL lipoproteins. Lipid poor oligomeric APOE is associated with the extracellular matrix in a calcium- and heparan-sulfate proteoglycans-dependent manner. Lipidation induces the release from the extracellular matrix. Colocalizes with CD63 and PMEL at exosomes and in intraluminal vesicles within multivesicular endosomes. {ECO:0000250|UniProtKB:P02649}.
uniprot
proteins