Inpp5b
entrez
16330
canonical
uniprot
Q8K337
canonical
ensembl
ENSMUSG00000028894
resolver
ensp
ENSMUSP00000092375
resolver
genesymbol
Inpp5b
resolver
uniprot
O54996
resolver
uniprot
Q8CF65
resolver
uniprot
Q91ZF8
resolver
uniprot_entry
I5P2_MOUSE
resolver
uniprot_sec
O54996
resolver
uniprot_sec
Q8CF65
resolver
uniprot_sec
Q91ZF8
resolver
amino_acid_sequence
MDQSVAIQETLVEGEYCVIAVQGVLCKGDSRQSRLLGLVRYRLENDAQEHALFLYTHRRMAITGDDVSLDQIVPLSKDFMLEEVSPDGELYILGSDVTVQLNTAELKLVFQLPFGSHTRTFLQEVARACPGFDPETRDPEFEWLSRHTCAEPDAESPKPREWNSDPGTRSGFAPIGGSRHQSRNARRGLEDVLPRGPGYILLWGGAAEEPEFLLAEEMHEGGPVRGRRPLAGRRDEALEEADWEMSAGGGSRERDCAGVSNVDSSRPNGRGPDQPSGARCPEKPENSLTRQNKSKSDMSEKVRSATVTVSDKAHILSVQKFGLRDTIVRSHLVQKEENYTYIQNFRFFVGTYNVNGQSPKECLRPWLSHSALAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSESLHPDAKYAKVKFVRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQLHNTSICVVNSHLAAHTEEYERRNQDYRDICSRMQFPQVDPSQPPLTINKHDVILWLGDLNYRIEELDVGKVKKLVEEKAFQTLYAHDQLKIQVAARTIFDGFTEGEITFQPTYKYDTGSDDWDTSEKCRAPAWCDRILWKGKNITQLSYQSHMALKTSDHKPVSSVFDIGVRVVNEELYRKTLEEIVRSLDKMENANIPSVTLSKREFCFENVKYMQLQTESFTIHNSQVPCQFEFINKPDEESYCKQWLTARPSKGFLLPDSHVEIELELFVNKSTATKLNSGKDTIEDILVLHLERGKDYFLSVSGNYLPSCFGSPIHTLCYMREPILDLPLKTVSDLTLMSVQTADDRSQLENPMEIPKELWMMVDYLYRNAVQQEDLFQQPGLRPEFDHIRDCLDTGMIDQLCANNHSVAEALLLFLESLPEPVICYSAYHSCLECSGNYAASKQIILTLPSFHKNVFNYLMAFLQELLKNSANNHLDENILASIFGSLLLRNPARHQKLDMAEKKKAQEFIHQFLCGPL
uniprot
proteins
ec_number
3.1.3.36
uniprot
proteins
ec_number
3.1.3.56
uniprot
proteins
function
FUNCTION: Regulates phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) cellular levels by cleaving the phosphate at the 5-position producing PtdIns(4)P. Also hydrolyzes the 5-position phosphate from inositol 1,4,5-trisphosphate (Ins(1,4,5)P3), thereby modulating cellular signaling events. {ECO:0000269|PubMed:11311145, ECO:0000269|PubMed:9525932}.
uniprot
proteins
mass_dalton
112762
uniprot
proteins
post_translational_modification
PTM: Isoprenylation at Cys-990 may be required for localization at the membrane. {ECO:0000250|UniProtKB:P32019}.; PTM: May be proteolytically cleaved after Lys-320 as inferred from N-terminal protein sequence of the 75 kda form. {ECO:0000250|UniProtKB:P32019}.
uniprot
proteins
protein_family
4
uniprot
proteins
protein_family
5-trisphosphate 5-phosphatase type II family
uniprot
proteins
protein_family
Inositol 1
uniprot
proteins
pubmed
11311145
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19536138
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22072788
uniprot
proteins
pubmed
25869668
uniprot
proteins
pubmed
9525932
uniprot
proteins
sequence_length
993
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:9525932}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250|UniProtKB:P32019}. Early endosome membrane {ECO:0000250|UniProtKB:P32019}. Membrane {ECO:0000250|UniProtKB:P32019}; Peripheral membrane protein {ECO:0000250|UniProtKB:P32019}; Cytoplasmic side {ECO:0000250|UniProtKB:P32019}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:9525932}.
uniprot
proteins