LDB1
entrez
8861
canonical
uniprot
Q86U70
canonical
ensembl
ENSG00000198728
resolver
ensp
ENSP00000354616
resolver
ensp
ENSP00000392466
resolver
ensp
ENSP00000501277
resolver
enst
ENST00000425280
resolver
genesymbol
LDB1
resolver
genesymbol_syn
CLIM2
resolver
hgnc
HGNC:6532
resolver
uniprot
A0A6E1WJ75
resolver
uniprot
B4DUC4
resolver
uniprot
O75479
resolver
uniprot
O96010
resolver
uniprot
Q1EQX1
resolver
uniprot
Q9UGM4
resolver
uniprot_entry
A0A6E1WJ75_HUMAN
resolver
uniprot_entry
LDB1_HUMAN
resolver
uniprot_sec
B4DUC4
resolver
uniprot_sec
O75479
resolver
uniprot_sec
O96010
resolver
uniprot_sec
Q1EQX1
resolver
uniprot_sec
Q9UGM4
resolver
amino_acid_sequence
MSVGCACPGCSSKSFKLYSPKEPPNGNAFPPFHPGTMLDRDVGPTPMYPPTYLEPGIGRHTPYGNQTDYRIFELNKRLQNWTEECDNLWWDAFTTEFFEDDAMLTITFCLEDGPKRYTIGRTLIPRYFRSIFEGGATELYYVLKHPKEAFHSNFVSLDCDQGSMVTQHGKPMFTQVCVEGRLYLEFMFDDMMRIKTWHFSIRQHRELIPRSILAMHAQDPQMLDQLSKNITRCGLSNSTLNYLRLCVILEPMQELMSRHKTYSLSPRDCLKTCLFQKWQRMVAPPAEPTRQQPSKRRKRKMSGGSTMSSGGGNTNNSNSKKKSPASTFALSSQVPDVMVVGEPTLMGGEFGDEDERLITRLENTQFDAANGIDDEDSFNNSPALGANSPWNSKPPSSQESKSENPTSQASQ
uniprot
proteins
function
FUNCTION: Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state. {ECO:0000250|UniProtKB:P70662}.
uniprot
proteins
mass_dalton
46533
uniprot
proteins
mutagenesis
MUTAGEN 245..249; /note="LCVIL->ACVAA: Abolishes interaction with ESR1."; /evidence="ECO:0000269|PubMed:19117995
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome. {ECO:0000250|UniProtKB:P70662}.
uniprot
proteins
protein_family
LDB family
uniprot
proteins
pubmed
10083735
uniprot
proteins
pubmed
10640831
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16815859
uniprot
proteins
pubmed
16959763
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
19117995
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21076045
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
32417234
uniprot
proteins
pubmed
9799849
uniprot
proteins
sequence_length
411
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P70662}. Note=Colocalizes with SLK at leading edges. {ECO:0000250|UniProtKB:P70662}.
uniprot
proteins