Dhx33
entrez
216877
canonical
uniprot
Q80VY9
canonical
ensembl
ENSMUSG00000040620
resolver
ensp
ENSMUSP00000104167
resolver
enst
ENSMUST00000108527
resolver
genesymbol
Dhx33
resolver
uniprot
Q8BS50
resolver
uniprot_entry
DHX33_MOUSE
resolver
uniprot_sec
Q8BS50
resolver
amino_acid_sequence
MPEEASLPPAKRFRPGSCPPGRRVVMLLTAGGGGGAGGGRRQTPPLAQPSASPYREALELQRRSLPIFRARGQLLAQLRNLDNAVLIGETGSGKTTQIPQYLYEGGISRQGIIAVTQPRRVAAISLATRVSDEKRTELGKLVGYTVRFEDVTSEDTRIKFLTDGMLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKTAQKRRKELGKLPLKVIVMSATMDVDLFSQYFNRAPVLYLEGRQHPIQIFYTKQPQQDYLHAALVSVFQIHQEAPASQDILVFLTGQEEIEAMSKTCRDIARHLPDGCPSMLVLPLYASLPYSQQLRVFQGAPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTGRAGREDSGICYRLYTEDEFEKFEKMTVPEIQRCNLASVILQLLAMKVPNVLTFDFMSKPSPDHIEAAIAQLDLLGALEHKDDQLTLTPIGRKMAAFPLEPRFAKTILLSSKFHCTEEILTIVSLLSVDSVLYNPPARRDEVQSVRKKFISSEGDHITLLNIYRTFKNIGGNKDWCKENFVNSKNMLLVAEVRAQLREICLKMSMPIMSSRGDMESVRRCMAHSLFMNTAELQTDGTYATTDTHQPVAIHPSSVLFHCKPACVVYTSLLYTNKCYMRDLCVVDAEWLYEAAPDYFRRKLRTARN
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: Implicated in nucleolar organization, ribosome biogenesis, protein synthesis and cytoplasmic dsRNA sensing (By similarity) (PubMed:21930779). Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment (PubMed:21930779). In the cytoplasm, promotes elongation-competent 80S ribosome assembly at the late stage of mRNA translation initiation (PubMed:26100019). Senses cytosolic dsRNA mediating NLRP3 inflammasome formation in macrophages and type I interferon production in myeloid dendritic cells (By similarity). Required for NLRP3 activation induced by viral dsRNA and bacterial RNA (By similarity). In dendritic cells, required for induction of type I interferon production induced by cytoplasmic dsRNA via the activation of MAPK and NF-kappa-B signaling pathways (PubMed:24037184). {ECO:0000250|UniProtKB:Q9H6R0, ECO:0000269|PubMed:21930779, ECO:0000269|PubMed:24037184, ECO:0000269|PubMed:26100019}.
uniprot
proteins
mass_dalton
78347
uniprot
proteins
mutagenesis
MUTAGEN 94; /note="K->N,R: Loss of stimulation of rRNA synthesis. Loss of protein synthesis promotion. No effect on interaction with DDX3X, EIF3G, EIF3H and RPL27."; /evidence="ECO:0000269|PubMed:21930779, ECO:0000269|PubMed:26100019
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, leading to its degradation by the proteasome (PubMed:29273634). Deubiquitinated by USP36 (PubMed:29273634). {ECO:0000269|PubMed:29273634}.
uniprot
proteins
protein_family
DEAD box helicase family
uniprot
proteins
protein_family
DEAH subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21930779
uniprot
proteins
pubmed
24037184
uniprot
proteins
pubmed
26100019
uniprot
proteins
pubmed
29273634
uniprot
proteins
sequence_length
698
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:21930779}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9H6R0}. Cytoplasm {ECO:0000250|UniProtKB:Q9H6R0}. Nucleus {ECO:0000250|UniProtKB:Q9H6R0}. Inflammasome {ECO:0000250|UniProtKB:Q9H6R0}. Note=Predominantly in the nucleolus. During mitosis, localizes with the nucleolar organizing regions. Upon dsRNA-binding, localizes in the inflammasome. {ECO:0000250|UniProtKB:Q9H6R0}.
uniprot
proteins