Dnase2
entrez
13423
canonical
uniprot
P56542
canonical
ensembl
ENSMUSG00000003812
resolver
ensp
ENSMUSP00000003910
resolver
ensp
ENSMUSP00000105366
resolver
enst
ENSMUST00000003910
resolver
enst
ENSMUST00000109744
resolver
genesymbol
Dnase2
resolver
genesymbol
Dnase2a
resolver
genesymbol_syn
Dnase2a
resolver
genesymbol_syn
Dnl2
resolver
uniprot
D3Z512
resolver
uniprot
O55053
resolver
uniprot
Q3UM14
resolver
uniprot_entry
D3Z512_MOUSE
resolver
uniprot_entry
DNS2A_MOUSE
resolver
uniprot_entry
Q3UM14_MOUSE
resolver
uniprot_sec
O55053
resolver
amino_acid_sequence
MATLRSLLLAALLWVPAEALSCYGDSGQPVDWFVVYKLPAHSGSRDTPKGLTYKYMDQNSDGWQDGVGYINSSEGAVGRSLQPLYRKNSSQLAFLLYNDQPPKSSSARDSTGHGHTKGVLLLDQEGGFWLVHSVPRFPPPASSGAYTWPPNAQTFGQTLLCVSLPFTQFARIGKQLTYTYPLVYDHKLEGFFAQKLPDLETVIKNQHVLHEPWNSSVILTSQAGATFQSFAKFGKFGDDLYSGWLAEALGTNLQVQFWQNSPGILPSNCSGAYQVLDVTQTGFPGPSRLTFSATEDHSKWCVAPQGPWACVGDMNRNKAETHRGGGTVCTQLPSFWKAFQSLVKDWKPCIEGS
uniprot
proteins
disease_involvement
DISEASE: Note=Absence of Dnase2 is a cause of severe fetal anemia and of perinatal lethality due to malformation of the diaphragm. {ECO:0000269|PubMed:11375492, ECO:0000269|PubMed:12181746}.
uniprot
proteins
ec_number
3.1.22.1
uniprot
proteins
function
FUNCTION: Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the clearance of nucleic acids generated through apoptosis, hence preventing autoinflammation. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver and bone marrow, where it degrades nuclear DNA expelled from erythroid precursor cells. {ECO:0000269|PubMed:11375492, ECO:0000269|PubMed:12181746, ECO:0000269|PubMed:23516607}.
uniprot
proteins
mass_dalton
38811
uniprot
proteins
protein_family
DNase II family
uniprot
proteins
pubmed
10903447
uniprot
proteins
pubmed
11375492
uniprot
proteins
pubmed
12181746
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23516607
uniprot
proteins
pubmed
9714827
uniprot
proteins
sequence_length
353
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:23516607}.
uniprot
proteins