ICAM1
entrez
3383
canonical
uniprot
P05362
canonical
ensembl
ENSG00000090339
resolver
ensp
ENSP00000264832
resolver
enst
ENST00000264832
resolver
genesymbol
ICAM1
resolver
hgnc
HGNC:5344
resolver
uniprot
A0A384MEK5
resolver
uniprot
B2R6M3
resolver
uniprot
Q5NKV7
resolver
uniprot
Q96B50
resolver
uniprot_entry
A0A384MEK5_HUMAN
resolver
uniprot_entry
ICAM1_HUMAN
resolver
uniprot_sec
B2R6M3
resolver
uniprot_sec
Q5NKV7
resolver
uniprot_sec
Q96B50
resolver
amino_acid_sequence
MAPSSPRPALPALLVLLGALFPGPGNAQTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGIETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAPLPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVRRDHHGANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLDGLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQETLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKATPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQAWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNVLSPRYEIVIITVVAAAVIMGTAGLSTYLYNRQRKIKKYRLQQAQKGTPMKPNTQATPP
uniprot
proteins
function
FUNCTION: Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring leukocyte cell-cell adhesion, by providing a calibrated system to namely adjust T-cell killing to the antigen stimulation strength (PubMed:3086451, PubMed:3340213, PubMed:38195629). Also functions as a ligand receptor of the signaling receptor ITGAM:ITGB2/MAC-1 ensuring adhesion between stimulated neutrophils and stimulated endothelial cells (PubMed:1980124). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation (PubMed:17875742). Promotes cell aggregation in epithelial cells through interaction with MUC1 (PubMed:11173916). {ECO:0000269|PubMed:11173916, ECO:0000269|PubMed:17875742, ECO:0000269|PubMed:1980124, ECO:0000269|PubMed:3086451, ECO:0000269|PubMed:3340213, ECO:0000269|PubMed:38195629}.; FUNCTION: (Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins. {ECO:0000269|PubMed:1968231, ECO:0000269|PubMed:2538243}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus A21 capsid proteins. {ECO:0000269|PubMed:11160747, ECO:0000269|PubMed:16004874, ECO:0000269|PubMed:9539703}.; FUNCTION: (Microbial infection) Upon Kaposi's sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell. {ECO:0000269|PubMed:11413168}.
uniprot
proteins
mass_dalton
57825
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis. {ECO:0000269|PubMed:17174307}.
uniprot
proteins
protein_family
ICAM family
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
10391210
uniprot
proteins
pubmed
10562537
uniprot
proteins
pubmed
11160747
uniprot
proteins
pubmed
11173916
uniprot
proteins
pubmed
11413168
uniprot
proteins
pubmed
12526797
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15099525
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15572059
uniprot
proteins
pubmed
16004874
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
1680919
uniprot
proteins
pubmed
17174307
uniprot
proteins
pubmed
17875742
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19139490
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
1968231
uniprot
proteins
pubmed
1980124
uniprot
proteins
pubmed
1983003
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23858057
uniprot
proteins
pubmed
24041930
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2538243
uniprot
proteins
pubmed
2544880
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
3086451
uniprot
proteins
pubmed
3340213
uniprot
proteins
pubmed
3349522
uniprot
proteins
pubmed
38195629
uniprot
proteins
pubmed
7525451
uniprot
proteins
pubmed
8557254
uniprot
proteins
pubmed
9259284
uniprot
proteins
pubmed
9539702
uniprot
proteins
pubmed
9539703
uniprot
proteins
sequence_length
532
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:3086451, ECO:0000269|PubMed:3340213}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 481..503; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins