Pafah2
entrez
313611
canonical
uniprot
P83006
canonical
ensembl
ENSRNOG00000022288
resolver
ensp
ENSRNOP00000103411
resolver
enst
ENSRNOT00000166584
resolver
genesymbol
Pafah2
resolver
uniprot
Q80Z89
resolver
uniprot_entry
PAFA2_RAT
resolver
uniprot_sec
Q80Z89
resolver
amino_acid_sequence
MGAGQSICFPPISGPHHIGCTDVMEGHSLEGSLFRLFYPCEASETCEQPLWIPRYEYCVGLADYLQYNKRWVGLLFNVGIGSCRLPVSWNGPFKTKESGYPLIILSHGLGGFRVSYSAFCMELASRGFVVAAIEHRDQSAAATYFCKQTSQESSPTESLEEEWIPFRRIKEGEKEFHVRNPQVHQRAKECVRVLQILQDASAGKPVINVFPGGLDLMTLKGSIDMSRVAVMGHSFGGATAILALTQEAQFRCAIALDAWMFPLEHDFYPKARGPVFFINVEKFQTVESVNLMKKICAQHEQSRIVTVLGAVHRSQTDFAFVTGNMIGKLFSSGTRGTLDPYEGQEVMVRAMLAFLQKHLDLKEDYDQWNSFIEGIGPSLIQGAPHYLSSL
uniprot
proteins
ec_number
2.3.1.149
uniprot
proteins
ec_number
3.1.1.47
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolyze of the acetyl group at the sn-2 position of platelet-activating factor (PAF) and its analogs, leading to their inactivation (PubMed:10085103). Hydrolyzes propionyl and butyroyl moieties approximately half as effectively as PAF (By similarity). Also catalyzes transacetylation of the acetyl group from platelet-activating factor (PAF) to lysoplasmalogen and to sphingosine, producing plasmalogen analogs of PAF and N-acetylsphingosine (C2-ceramide) respectively (PubMed:10085103). Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position (PubMed:10085103). {ECO:0000250|UniProtKB:P79106, ECO:0000269|PubMed:10085103}.
uniprot
proteins
mass_dalton
43492
uniprot
proteins
protein_family
Serine esterase family
uniprot
proteins
pubmed
10085103
uniprot
proteins
sequence_length
390
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000269|PubMed:10085103}; Lipid-anchor {ECO:0000250|UniProtKB:P79106}. Mitochondrion membrane {ECO:0000269|PubMed:10085103}; Lipid-anchor {ECO:0000250|UniProtKB:P79106}. Cytoplasm {ECO:0000250|UniProtKB:P79106}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:10085103}; Lipid-anchor {ECO:0000250|UniProtKB:P79106}. Note=In resting cells, localizes to intracellular membranes and cytoplasm. Translocates from the cytoplasm to intracellular membranes upon oxidative stress. {ECO:0000250|UniProtKB:P79106}.
uniprot
proteins