MAP4K3
entrez
8491
canonical
uniprot
Q8IVH8
canonical
ensembl
ENSG00000011566
resolver
ensp
ENSP00000263881
resolver
ensp
ENSP00000345434
resolver
ensp
ENSP00000416958
resolver
ensp
ENSP00000661195
resolver
enst
ENST00000437545
resolver
genesymbol
MAP4K3
resolver
genesymbol_syn
RAB8IPL1
resolver
hgnc
HGNC:6865
resolver
uniprot
A8K602
resolver
uniprot
B3KMM5
resolver
uniprot
B4DSS3
resolver
uniprot
F5H5A3
resolver
uniprot
Q6IQ39
resolver
uniprot
Q8IVH7
resolver
uniprot
Q9UDM5
resolver
uniprot
Q9Y6R5
resolver
uniprot_entry
A8K602_HUMAN
resolver
uniprot_entry
B3KMM5_HUMAN
resolver
uniprot_entry
B4DSS3_HUMAN
resolver
uniprot_entry
F5H5A3_HUMAN
resolver
uniprot_entry
M4K3_HUMAN
resolver
uniprot_sec
Q6IQ39
resolver
uniprot_sec
Q8IVH7
resolver
uniprot_sec
Q9UDM5
resolver
uniprot_sec
Q9Y6R5
resolver
amino_acid_sequence
MNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHPNIVAYFGSYLRRDKLWICMEFCGGGSLQDIYHVTGPLSELQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVSAQITATIAKRKSFIGTPYWMAPEVAAVERKGGYNQLCDLWAVGITAIELAELQPPMFDLHPMRALFLMTKSNFQPPKLKDKMKWSNSFHHFVKMALTKNPKKRPTAEKLLQHPFVTQHLTRSLAIELLDKVNNPDHSTYHDFDDDDPEPLVAVPHRIHSTSRNVREEKTRSEITFGQVKFDPPLRKETEPHHELPDSDGFLDSSEEIYYTARSNLDLQLEYGQGHQGGYFLGANKSLLKSVEEELHQRGHVAHLEDDEGDDDESKHSTLKAKIPPPLPPKPKSIFIPQEMHSTEDENQGTIKRCPMSGSPAKPSQVPPRPPPPRLPPHKPVALGNGMSSFQLNGERDGSLCQQQNEHRGTNLSRKEKKDVPKPISNGLPPTPKVHMGACFSKVFNGCPLKIHCASSWINPDTRDQYLIFGAEEGIYTLNLNELHETSMEQLFPRRCTWLYVMNNCLLSISGKASQLYSHNLPGLFDYARQMQKLPVAIPAHKLPDRILPRKFSVSAKIPETKWCQKCCVVRNPYTGHKYLCGALQTSIVLLEWVEPMQKFMLIKHIDFPIPCPLRMFEMLVVPEQEYPLVCVGVSRGRDFNQVVRFETVNPNSTSSWFTESDTPQTNVTHVTQLERDTILVCLDCCIKIVNLQGRLKSSRKLSSELTFDFQIESIVCLQDSVLAFWKHGMQGRSFRSNEVTQEISDSTRIFRLLGSDRVVVLESRPTDNPTANSNLYILAGHENSY
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine kinase that plays a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway (PubMed:9275185). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:9275185}.
uniprot
proteins
mass_dalton
101316
uniprot
proteins
mutagenesis
MUTAGEN 45; /note="K->E: Loss of kinase activity and ability to activate JNK family."; /evidence="ECO:0000269|PubMed:9275185
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
protein_family
STE20 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
26437443
uniprot
proteins
pubmed
9275185
uniprot
proteins
sequence_length
894
uniprot
proteins