Mepce
entrez
231803
canonical
uniprot
Q8K3A9
canonical
ensembl
ENSMUSG00000029726
resolver
ensp
ENSMUSP00000031740
resolver
enst
ENSMUST00000031740
resolver
genesymbol
Mepce
resolver
genesymbol_syn
Bcdin3
resolver
genesymbol_syn
Bipl1
resolver
genesymbol_syn
D5Wsu46e
resolver
uniprot
Q2YFS5
resolver
uniprot
Q3U465
resolver
uniprot
Q3UT64
resolver
uniprot
Q91W35
resolver
uniprot_entry
MEPCE_MOUSE
resolver
uniprot_sec
Q2YFS5
resolver
uniprot_sec
Q3U465
resolver
uniprot_sec
Q3UT64
resolver
uniprot_sec
Q91W35
resolver
amino_acid_sequence
MIEMAAEKEPFLVPAPPPPLKDESGGGGGPEVQSHQEAASGELRDGTEHGPGPRAHSAGAAASGGGGPQAQAHGEPHGRAAAPADVGEERRGGGGTDLGPPAPPRPRNGYQPHRPPGGGGGKRRNSCNVGGGSGGSFKHPAFKRRRRVNSDCDSVLPSNFLLGGNIFDPLNLNSLLDEEVSRALNAETPKSSPLPAKGRDPVEILIPKDITDPLSLNTCTDEAHVVLASPLKIGRKRHRHRGPHHQQQQQASGGNDSNAAVLPTDPLTPSLHGEGATQQQQNRGQNRDAPQPYELNTAINCRDEVVSPLPSALQGSSGSLSAPPAASVTSAPSTSSSSRHRKRRRTSSKSEAGARGGSQGSKEKGRGSGGGRHHHHPLPATGFKKQQLKFQYGNYCKYYGYRNPSCEDVRLRVLKPEWFQGRDVLDLGCNVGHLTLSIACKWGPARMVGLDIDPRLIHSARQNIRHYLSEELRLQAQTSEGDPGTEGEEGTITVRKRSCFPASLTASRGPIAAPQVPLDGADTSVFPNNVVFVTGNYVLDRDELVDAQRPEYDVVLCFSLTKWVHLNWGDEGLKRMFRRIYRHLRPGGILVLEPQPWSSYCKRKSLTETIYKNYFRIQLKPEQFSSYLTSPEVGFSSYELVATPNNTSRGFQRPVYLFHKARSPSH
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (By similarity). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:23154982). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (By similarity). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (By similarity). MEPCE has a non-enzymatic function in the 7SK RNP complex; it has a non-enzymatic function; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (By similarity). Also required for stability of U6 snRNAs (By similarity). {ECO:0000250|UniProtKB:Q7L2J0, ECO:0000269|PubMed:23154982}.
uniprot
proteins
mass_dalton
72050
uniprot
proteins
post_translational_modification
PTM: Dephosphorylated at Ser-126 by the PNUTS-PP1 complex, promoting RNA polymerase II transcription pause-release. {ECO:0000250|UniProtKB:Q7L2J0}.
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16926269
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23154982
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
666
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7L2J0}.
uniprot
proteins