Eif5a
entrez
276770
canonical
uniprot
P63242
canonical
ensembl
ENSMUSG00000078812
resolver
ensp
ENSMUSP00000047008
resolver
ensp
ENSMUSP00000067077
resolver
ensp
ENSMUSP00000068651
resolver
ensp
ENSMUSP00000104247
resolver
ensp
ENSMUSP00000104248
resolver
ensp
ENSMUSP00000104249
resolver
ensp
ENSMUSP00000104250
resolver
ensp
ENSMUSP00000104251
resolver
ensp
ENSMUSP00000104252
resolver
ensp
ENSMUSP00000104253
resolver
ensp
ENSMUSP00000132717
resolver
ensp
ENSMUSP00000200166
resolver
ensp
ENSMUSP00000200170
resolver
ensp
ENSMUSP00000200184
resolver
ensp
ENSMUSP00000200187
resolver
enst
ENSMUST00000043419
resolver
enst
ENSMUST00000070996
resolver
enst
ENSMUST00000071026
resolver
enst
ENSMUST00000108607
resolver
enst
ENSMUST00000108608
resolver
enst
ENSMUST00000108609
resolver
enst
ENSMUST00000108610
resolver
enst
ENSMUST00000108611
resolver
enst
ENSMUST00000108612
resolver
enst
ENSMUST00000108613
resolver
enst
ENSMUST00000164359
resolver
genesymbol
Eif5a
resolver
uniprot
P10159
resolver
uniprot
Q16182
resolver
uniprot
Q5NCX0
resolver
uniprot
Q78NR3
resolver
uniprot
Q9D0G2
resolver
uniprot_entry
IF5A1_MOUSE
resolver
uniprot_sec
P10159
resolver
uniprot_sec
Q16182
resolver
uniprot_sec
Q5NCX0
resolver
uniprot_sec
Q78NR3
resolver
uniprot_sec
Q9D0G2
resolver
amino_acid_sequence
MADDLDFETGDAGASATFPMQCSALRKNGFVVLKGRPCKIVEMSTSKTGKHGHAKVHLVGIDIFTGKKYEDICPSTHNMDVPNIKRNDFQLIGIQDGYLSLLQDSGEVREDLRLPEGDLGKEIEQKYDCGEEILITVLSAMTEEAAVAIKAMAK
uniprot
proteins
function
FUNCTION: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts (By similarity). Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome (By similarity). Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity (By similarity). With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis (By similarity). Also regulates TNF-mediated apoptosis (By similarity). Mediates effects of polyamines on neuronal process extension and survival (PubMed:15377278). Is required for autophagy by assisting the ribosome in translating the ATG3 protein at a specific amino acid sequence, the 'ASP-ASP-Gly' motif, leading to the increase of the efficiency of ATG3 translation and facilitation of LC3B lipidation and autophagosome formation (By similarity). {ECO:0000250|UniProtKB:P23301, ECO:0000250|UniProtKB:P63241, ECO:0000269|PubMed:15377278}.
uniprot
proteins
mass_dalton
16832
uniprot
proteins
post_translational_modification
PTM: Acetylated by PCAF/KAT2B, regulating its subcellular localization (By similarity). Deacetylated by SIRT2 (By similarity). {ECO:0000250|UniProtKB:P63241}.; PTM: Lys-50 undergoes hypusination, a unique post-translational modification that consists in the addition of a butylamino group from spermidine to lysine side chain, leading to the formation of the unusual amino acid hypusine. eIF-5As are the only known proteins to undergo this modification, which is essential for their function. {ECO:0000269|PubMed:15377278}.
uniprot
proteins
protein_family
EIF-5A family
uniprot
proteins
pubmed
15377278
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17707773
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
154
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17707773}. Nucleus {ECO:0000269|PubMed:17707773}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P63241}; Peripheral membrane protein {ECO:0000250|UniProtKB:P63241}; Cytoplasmic side {ECO:0000250|UniProtKB:P63241}. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions. Nuclear export of hypusinated protein is mediated by XPO4. {ECO:0000250|UniProtKB:P63241}.
uniprot
proteins