KCNJ14
entrez
3770
canonical
uniprot
Q9UNX9
canonical
ensembl
ENSG00000182324
resolver
ensp
ENSP00000341479
resolver
ensp
ENSP00000375756
resolver
enst
ENST00000342291
resolver
enst
ENST00000391884
resolver
genesymbol
KCNJ14
resolver
genesymbol_syn
IRK4
resolver
hgnc
HGNC:6260
resolver
uniprot_entry
KCJ14_HUMAN
resolver
activity_regulation
ACTIVITY REGULATION: Channel activity is regulated by variations of cytosolic pH; channels are activated by alkaline and inhibited by acidic pH values (PubMed:10942728). Inhibited by Ba(2+) and Cs(+) in a voltage-dependent manner; sensitivity to those inhibitors is lower than in other Kir channels (PubMed:10942728). {ECO:0000269|PubMed:10942728}.
uniprot
proteins
amino_acid_sequence
MGLARALRRLSGALDSGDSRAGDEEEAGPGLCRNGWAPAPVQSPVGRRRGRFVKKDGHCNVRFVNLGGQGARYLSDLFTTCVDVRWRWMCLLFSCSFLASWLLFGLAFWLIASLHGDLAAPPPPAPCFSHVASFLAAFLFALETQTSIGYGVRSVTEECPAAVAAVVLQCIAGCVLDAFVVGAVMAKMAKPKKRNETLVFSENAVVALRDHRLCLMWRVGNLRRSHLVEAHVRAQLLQPRVTPEGEYIPLDHQDVDVGFDGGTDRIFLVSPITIVHEIDSASPLYELGRAELARADFELVVILEGMVEATAMTTQCRSSYLPGELLWGHRFEPVLFQRGSQYEVDYRHFHRTYEVPGTPVCSAKELDERAEQASHSLKSSFPGSLTAFCYENELALSCCQEEDEDDETEEGNGVETEDGAASPRVLTPTLALTLPP
uniprot
proteins
function
FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. {ECO:0000269|PubMed:10942728}.
uniprot
proteins
mass_dalton
47846
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ14 subfamily
uniprot
proteins
pubmed
10723734
uniprot
proteins
pubmed
10942728
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
436
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 84..110; /note="Helical; Name=M1"; /evidence="ECO:0000250|UniProtKB:F1NHE9"; TRANSMEM 160..187; /note="Helical; Name=M2"; /evidence="ECO:0000250|UniProtKB:F1NHE9
uniprot
proteins