Trim66
entrez
330627
canonical
uniprot
Q924W6
canonical
ensembl
ENSMUSG00000031026
resolver
ensp
ENSMUSP00000033339
resolver
ensp
ENSMUSP00000102350
resolver
ensp
ENSMUSP00000102352
resolver
enst
ENSMUST00000106739
resolver
genesymbol
Trim66
resolver
genesymbol_syn
Tif1d
resolver
uniprot
E9PZP2
resolver
uniprot
E9QKN7
resolver
uniprot
E9QLR8
resolver
uniprot
Q3UH62
resolver
uniprot
Q5SEK4
resolver
uniprot
Q5SEK5
resolver
uniprot_entry
E9PZP2_MOUSE
resolver
uniprot_entry
Q3UH62_MOUSE
resolver
uniprot_entry
TRI66_MOUSE
resolver
uniprot_sec
E9QKN7
resolver
uniprot_sec
E9QLR8
resolver
uniprot_sec
Q5SEK4
resolver
uniprot_sec
Q5SEK5
resolver
amino_acid_sequence
MSPGLPVSIPSQPHCSTDERVEALAPTCSMCGRDLQAEGSRLLPCQHLLCKDCYQGFMQELGHATRAYPGKLISCPGCQRVYLTRDVTEHIFLQCFSPVKPTMARNCSECKEKRAAHILCTYCNRWLCSSCTEEHRHVPAPGGPLFARAQKGSSGVNGGSGDFALYCPLHTQEVLKLFCETCDVLTCHSCLMVEHKEHRCRHVEEVLQNQRMLLESVTSQVAHKKSSLQTSAKQIEDRIFEVKHQHRKVENQIKMAKMVLMNELNKQANGLIEELEGITNERKRKLEQQLQSIMVLNRQFEHVQNFINWAVCSKSSVPFLFSKELIVFQMQRLLETRCNTDPGSPWSIRFTWEPNFWTKQLASLGCITTEGGQLTRADAAAASYGSLQGQPSFYQSHQAPMAQQEALSHPSHKFQSPALCSSSVCCSHCSPVSPSLKGQVPPPSIHPAHSFRQPSEMVPHQLGSLQCSTLLPREKELACSPHPPKLMQPWLEPQPPAEQESTSQRPGPQLVSQPVCIVPPQDVQPGAHAQPTIQTPSIQVQLGHHQKLKLSHFQQQPQQQPPPPPPPPPPPQHAPPPLPPSQHLASSQHESPPGPACSQNVDIMHHKFELEEMQKDLELLLQAQQPSLQLSQTKSPQHLQQTIVGQINYIVRQPAPVQSQSQEETLQVTEEPPAPEGPKPALPVDKNTAAPLPQTSGEETPHSVPPVDGTSQHSSPNVVRKHATSVSIMGFSNTVEMELSSTRLARTIEPQIHRVSSLTAAPTHTIPSLLSGPPQTVSSLMSVSNHAMPSLTASHLQPVPNLVRGTFQSTSNLRGDSSQAITGLASNHSQAGPSLMSGHTQAAPSLATCPLQGMPPVSDVHVEPRSVSSPGSGPAAESLGTRDGAESSLGNALCKMESEDCTRFSDSVGQGPTASSLDGPKDLAIPSELEEPINLSVKKPFLAPVINTSTALQQYRNPKEYENFEQGALELDTKENSDIRAISSEPKIPYVRLERLKICAASSGEMPVFKLKPQKNSQDGNFLLVIECGTESSSMSIKVSQNSLPDASQGPGLGGRKVTVTSLTGQQPQEVESTSEEHRLIPRAPGAKKNTPAPIENEDFCAVCINGGELLCCDRCPKVYHLSCHVPALLSFPGGEWVCTLCRSLTQPEMEYDCENARYGHPGVRVLPGLSMYDQKKCEKLVLSLCCNSLSLPFHEPVSPLARHYYQIIKRPMDLSIIRRKLQKKDPAHYTTPEEVVSDVRLMFWNCAKFNYPDSEVAEAGRCLEVFFEGWLKEIYPDKCFAQPQQEDSDSEDVSGESGCSTPQGFPWPPYMQEGIQPKRRRRHMENEKTKRVSFRLANSISQV
uniprot
proteins
function
FUNCTION: May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association. {ECO:0000269|PubMed:15322135}.
uniprot
proteins
mass_dalton
148001
uniprot
proteins
mutagenesis
MUTAGEN 991; /note="V->A: Drastic decrease of CBX5, CBX1 and CBX3 binding; When associated with A-993."; /evidence="ECO:0000269|PubMed:15322135"; MUTAGEN 993; /note="L->A: Drastic decrease of CBX5, CBX1 and CBX3 binding; When associated with A-991."; /evidence="ECO:0000269|PubMed:15322135
uniprot
proteins
pubmed
11528127
uniprot
proteins
pubmed
15322135
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
1344
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15322135}. Note=Forms discrete foci within the centromeric chromocenter and surrounding nucleoplasm.
uniprot
proteins