Csnk1g2
entrez
65278
canonical
uniprot
Q62762
canonical
ensembl
ENSRNOG00000018529
resolver
ensembl
ENSRNOG00055031957
resolver
ensembl
ENSRNOG00060030231
resolver
ensembl
ENSRNOG00065018469
resolver
ensp
ENSRNOP00000025266
resolver
ensp
ENSRNOP00000072196
resolver
ensp
ENSRNOP00055045663
resolver
ensp
ENSRNOP00060043689
resolver
ensp
ENSRNOP00065024705
resolver
enst
ENSRNOT00000025266
resolver
enst
ENSRNOT00000080342
resolver
enst
ENSRNOT00055055292
resolver
enst
ENSRNOT00060052517
resolver
enst
ENSRNOT00065031018
resolver
genesymbol
Csnk1g2
resolver
genesymbol_syn
Ck1g2
resolver
uniprot
A0A0H2UHQ2
resolver
uniprot
Q6IMY5
resolver
uniprot_entry
A0A0H2UHQ2_RAT
resolver
uniprot_entry
KC1G2_RAT
resolver
uniprot_sec
Q6IMY5
resolver
activity_regulation
ACTIVITY REGULATION: Stimulated by estrogen. {ECO:0000250|UniProtKB:P78368}.
uniprot
proteins
amino_acid_sequence
MDFDKKGGKGELEEGRRMSKTGTNRSNHGVRNSGTSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSTTEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGSKRQHSIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCESFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRSGYVFDYEYDWAGKPLPTPIGTVHPDVPSQPPHRDKAQLHTKNQALNSTNGELNTDDPTAGHSNAPIAAPAEVEVADETKCCCFFKRRKRKSLQRHK
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation (By similarity). Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate (By similarity). Involved in regulation of reactive oxygen species (ROS) levels (By similarity). {ECO:0000250|UniProtKB:P48729, ECO:0000250|UniProtKB:P78368, ECO:0000250|UniProtKB:Q8BVP5}.
uniprot
proteins
mass_dalton
47636
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated (PubMed:7759525). Phosphorylated by aPKC which promotes dissociation from the cell cortex (By similarity). {ECO:0000250|UniProtKB:P78368, ECO:0000269|PubMed:7759525}.
uniprot
proteins
protein_family
CK1 Ser/Thr protein kinase family
uniprot
proteins
protein_family
Casein kinase I subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7759525
uniprot
proteins
sequence_length
415
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cell cortex {ECO:0000250|UniProtKB:P78368}. Cytoplasm {ECO:0000250|UniProtKB:P78368}.
uniprot
proteins