Gga3
entrez
360658
canonical
uniprot
A0A0G2JV04
canonical
ensembl
ENSRNOG00000027057
resolver
ensembl
ENSRNOG00065020195
resolver
ensp
ENSRNOP00000090243
resolver
ensp
ENSRNOP00000103708
resolver
ensp
ENSRNOP00065027439
resolver
enst
ENSRNOT00000114183
resolver
enst
ENSRNOT00065034262
resolver
genesymbol
Gga3
resolver
uniprot_entry
GGA3_RAT
resolver
amino_acid_sequence
MAEAEGESLESWLNKATNPSNRQEDWEYIIGFCDQINKELEGPQIAVRLLAHKIQSPQEWEAVQALTVLEACMKNCGRRLHNEVGKFRFLNELIKVVSPKYLGDRVSEKVKAKVIELLFSWTLALPEEAKIKDAYHMLKRQGIVQSDPPIPMDRTLIPSPPPRPKNPVFDDEEKSKLLAKLLRSKNPDDLQEANQLIKSMVKEDEARIQKVTKRLHTLEEVNNNVKLLHEMLLHYSQEFSSEADKELMKELFDRCENKRRTLFKLASETEDNDNSLGDILQASDNLSRVINSYKTIIEGQIINGEVTTSTVPDSEGNSHCGNQGALIDLAELDTPSSSSPVLAPAPAPPTSGIPILPPPPQTSGPPRSRSSSQAEAPSGPDSTNNALSLLDEELLCLGLSDPAPTAPKESAGNSPWHLFQNEPSSDLDFFSPRLVSAASCPSEGSLLPPPVSTSSLSQAPLPAAFPAPVVPASAVTHSTGSFTFSSGPAPALVPKAEPEGPEYPSSSISHRLDALDQLLEEAKVTSGLVKPVSCFSPGPTASPLLPASTPARPLLPFSTGPGSPLFQSPAFQSQGSPQKGPELSLASVHVPLESIKPSSALPVTAYDKNGFRILFHFAKECPPGRPDVLVVVVSMLNTAPLPVKSIVLQAAVPKSMKVKLQPPSGTELSPFSPIQPPAAITQVMLLANPMKEKVRLRYKLTFALGEQLSTELGEVDQFPPVEQWGNL
uniprot
proteins
function
FUNCTION: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. Involved in BACE1 transport and sorting as well as regulation of BACE1 protein levels. Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation. Modulates BACE1 protein levels independently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination (By similarity). Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane (PubMed:26446845). {ECO:0000250|UniProtKB:Q9NZ52, ECO:0000269|PubMed:26446845}.
uniprot
proteins
mass_dalton
78759
uniprot
proteins
mutagenesis
MUTAGEN 194; /note="N->A: Disrupts recycling of NTRK1 to the plasma membrane."; /evidence="ECO:0000269|PubMed:26446845
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CK2 and dephosphorylated by PP2A (By similarity). Phosphorylation of GGA3 allows the internal DXXLL motif to bind the VHS domain and to inhibit the recognition of cargo signals. {ECO:0000250}.; PTM: Ubiquitinated. {ECO:0000250|UniProtKB:Q9NZ52}.; PTM: Proteolytically cleaved during apoptosis by CASP3. {ECO:0000250|UniProtKB:Q9NZ52}.
uniprot
proteins
protein_family
GGA protein family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
26446845
uniprot
proteins
sequence_length
727
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q9NZ52}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9NZ52}. Endosome membrane {ECO:0000250|UniProtKB:Q9NZ52}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9NZ52}. Early endosome membrane {ECO:0000269|PubMed:26446845}; Peripheral membrane protein {ECO:0000305}. Recycling endosome membrane {ECO:0000269|PubMed:26446845}; Peripheral membrane protein {ECO:0000305}.
uniprot
proteins