Camk2g
entrez
171140
canonical
uniprot
P11730
canonical
ensembl
ENSRNOG00000009783
resolver
ensembl
ENSRNOG00055019165
resolver
ensembl
ENSRNOG00060012439
resolver
ensembl
ENSRNOG00065010269
resolver
ensp
ENSRNOP00000077055
resolver
ensp
ENSRNOP00000088587
resolver
ensp
ENSRNOP00000090198
resolver
ensp
ENSRNOP00000111753
resolver
enst
ENSRNOT00000107544
resolver
enst
ENSRNOT00000114050
resolver
enst
ENSRNOT00000120116
resolver
enst
ENSRNOT00000135346
resolver
genesymbol
Camk2g
resolver
uniprot
A0A8I5Y738
resolver
uniprot
A0A8I6A5E2
resolver
uniprot
A0A8I6AD45
resolver
uniprot
A0ABK0M3B6
resolver
uniprot
Q64003
resolver
uniprot
Q64004
resolver
uniprot_entry
A0A8I5Y738_RAT
resolver
uniprot_entry
A0A8I6A5E2_RAT
resolver
uniprot_entry
A0A8I6AD45_RAT
resolver
uniprot_entry
A0ABK0M3B6_RAT
resolver
uniprot_entry
KCC2G_RAT
resolver
uniprot_sec
Q64003
resolver
uniprot_sec
Q64004
resolver
activity_regulation
ACTIVITY REGULATION: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity. {ECO:0000250|UniProtKB:Q13555}.
uniprot
proteins
amino_acid_sequence
MATTATCTRFTDDYQLFEELGKGAFSVVRRCVKKTSTQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIHQILESVNHIHQHDIVHRDLKPENLLLASKCKGAAVKLADFGLAIEVQGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDIWACGVILYILLVGYPPFWDEDQHKLYQQIKAGAYDFPSPEWDTVTPEAKNLINQMLTINPAKRITADQALKHPWVCQRSTVASMMHRQETVECLRKFNARRKLKGAILTTMLVSRNFSVGRQSSAPASPAASAAGLAGQAAKSLLNKKSDGGVKKRKSSSSVHLMEPQTTVVHNATDGIKGSTESCNTTTEDEDLKVRKQEIIKITEQLIEAINNGDFEAYTKICDPGLTSFEPEALGNLVEGMDFHKFYFENLLSKNSKPIHTTILNPHVHVIGEDAACIAYIRLTQYIDGQGRPRTSQSEETRVWHRRDGKWLNVHYHCSGAPAAPLQ
uniprot
proteins
ec_number
2.7.11.17
uniprot
proteins
function
FUNCTION: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (By similarity). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (By similarity). In the central nervous system, it is involved in the regulation of neurite formation and arborization. It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q13555, ECO:0000250|UniProtKB:Q923T9}.
uniprot
proteins
mass_dalton
59038
uniprot
proteins
post_translational_modification
PTM: Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state (By similarity). {ECO:0000250|UniProtKB:Q13555}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
CaMK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
16891908
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2846534
uniprot
proteins
pubmed
8172610
uniprot
proteins
sequence_length
527
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
uniprot
proteins