TRUB2
entrez
26995
canonical
uniprot
O95900
canonical
ensembl
ENSG00000167112
resolver
ensp
ENSP00000361982
resolver
ensp
ENSP00000523338
resolver
genesymbol
TRUB2
resolver
hgnc
HGNC:17170
resolver
uniprot
B7Z7G5
resolver
uniprot_entry
TRUB2_HUMAN
resolver
uniprot_sec
B7Z7G5
resolver
amino_acid_sequence
MGSAGLSRLHGLFAVYKPPGLKWKHLRDTVELQLLKGLNARKPPAPKQRVRFLLGPMEGSEEKELTLTATSVPSFINHPLVCGPAFAHLKVGVGHRLDAQASGVLVLGVGHGCRLLTDMYNAHLTKDYTVRGLLGKATDDFREDGRLVEKTTYDHVTREKLDRILAVIQGSHQKALVMYSNLDLKTQEAYEMAVRGLIRPMNKSPMLITGIRCLYFAPPEFLLEVQCMHETQKELRKLVHEIGLELKTTAVCTQVRRTRDGFFTLDSALLRTQWDLTNIQDAIRAATPQVAAELEKSLSPGLDTKQLPSPGWSWDSQGPSSTLGLERGAGQ
uniprot
proteins
ec_number
5.4.99.-
uniprot
proteins
ec_number
5.4.99.25
uniprot
proteins
function
FUNCTION: Minor enzyme contributing to the isomerization of uridine to pseudouridine (pseudouridylation) of specific mitochondrial mRNAs (mt-mRNAs) such as COXI and COXIII mt-mRNAs (PubMed:27974379, PubMed:31477916). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664). Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs (PubMed:33023933). {ECO:0000269|PubMed:27667664, ECO:0000269|PubMed:27974379, ECO:0000269|PubMed:31477916, ECO:0000269|PubMed:33023933}.
uniprot
proteins
mass_dalton
36694
uniprot
proteins
protein_family
Pseudouridine synthase TruB family
uniprot
proteins
pubmed
12736709
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
27667664
uniprot
proteins
pubmed
27974379
uniprot
proteins
pubmed
28082677
uniprot
proteins
pubmed
31477916
uniprot
proteins
pubmed
33023933
uniprot
proteins
sequence_length
331
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:27974379, ECO:0000269|PubMed:33023933}. Note=Localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly. {ECO:0000269|PubMed:27974379, ECO:0000269|PubMed:28082677}.
uniprot
proteins