Slc4a2
entrez
20535
canonical
uniprot
P13808
canonical
ensembl
ENSMUSG00000028962
resolver
ensp
ENSMUSP00000078972
resolver
ensp
ENSMUSP00000110699
resolver
ensp
ENSMUSP00000110701
resolver
ensp
ENSMUSP00000173340
resolver
ensp
ENSMUSP00000173354
resolver
enst
ENSMUST00000080067
resolver
enst
ENSMUST00000115047
resolver
enst
ENSMUST00000115049
resolver
genesymbol
Slc4a2
resolver
genesymbol_syn
Ae2
resolver
uniprot
A0A0R4J101
resolver
uniprot
A0A0R4J1K4
resolver
uniprot
A0A0R4J1K9
resolver
uniprot
Q3UKP0
resolver
uniprot
Q7TPS4
resolver
uniprot
Q9ES09
resolver
uniprot
Q9ES10
resolver
uniprot
Q9ES11
resolver
uniprot
Q9ES12
resolver
uniprot
Q9ES13
resolver
uniprot_entry
A0A0R4J101_MOUSE
resolver
uniprot_entry
A0A0R4J1K4_MOUSE
resolver
uniprot_entry
A0A0R4J1K9_MOUSE
resolver
uniprot_entry
B3A2_MOUSE
resolver
uniprot_entry
Q3UKP0_MOUSE
resolver
uniprot_entry
Q7TPS4_MOUSE
resolver
uniprot_sec
Q9ES09
resolver
uniprot_sec
Q9ES10
resolver
uniprot_sec
Q9ES11
resolver
uniprot_sec
Q9ES12
resolver
uniprot_sec
Q9ES13
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid (DIDS) and acetazolamide (PubMed:12958022, PubMed:2371270). Muscarinic receptor stimulation enhances activity through a Ca(2+)-dependent mechanism (PubMed:12958022). {ECO:0000269|PubMed:12958022, ECO:0000269|PubMed:2371270}.
uniprot
proteins
amino_acid_sequence
MSSAPRRPASGADSLHTPEPESLSPGTPGFPEQEEDELRTLGVERFEEILQEAGSRGGEEPGRSYGEEDFEYHRQSSHHIHHPLSTHLPPDARRRKTPQGPGRKPRRRPGASPTGETPTIEEGEEDEEEASEAEGFRAPPQQPSPATTPSAVQFFLQEDEGAERKPERTSPSPPTQTPHQEAAPRASKGAQTGTLVEEMVAVASATAGGDDGGAAGRPLTKAQPGHRSYNLQERRRIGSMTGVEQALLPRVPTDESEAQTLATADLDLMKSHRFEDVPGVRRHLVRKNAKGSTQAAREGREPGPTPRARPRAPHKPHEVFVELNELLLDKNQEPQWRETARWIKFEEDVEEETERWGKPHVASLSFRSLLELRRTLAHGAVLLDLDQQTLPGVAHQVVEQMVISDQIKAEDRANVLRALLLKHSHPSDEKEFSFPRNISAGSLGSLLGHHHAQGTESDPHVTEPLIGGVPETRLEVDRERELPPPAPPAGITRSKSKHELKLLEKIPENAEATVVLVGCVEFLSRPTMAFVRLREAVELDAVLEVPVPVRFLFLLLGPSSANMDYHEIGRSISTLMSDKQFHEAAYLADERDDLLTAINAFLDCSVVLPPSEVQGEELLRSVAHFQRQMLKKREEQGRLLPPGAGLEPKSAQDKALLQMVEVAGAAEDDPLRRTGRPFGGLIRDVRRRYPHYLSDFRDALDPQCLAAVIFIYFAALSPAITFGGLLGEKTKDLIGVSELIMSTALQGVVFCLLGAQPLLVIGFSGPLLVFEEAFFSFCSSNELEYLVGRVWIGFWLVFLALLMVALEGSFLVRFVSRFTQEIFAFLISLIFIYETFYKLIKIFQEHPLHGCSGSNDSEAGSSSSSNMTWATTILVPDNSSASGQSGQEKPRGQPNTALLSLVLMAGTFFIAFFLRKFKNSRFFPGRIRRVIGDFGVPIAILIMVLVDYSIEDTYTQKLSVPSGFSVTAPDKRGWVINPLGEKTPFPVWMMVASLLPAVLVFILIFMETQITTLIISKKERMLQKGSGFHLDLLLIVAMGGICALFGLPWLAAATVRSVTHANALTVMSKAVAPGDKPKIQEVKEQRVTGLLVALLVGLSMVIGDLLRQIPLAVLFGIFLYMGVTSLNGIQFYERLHLLLMPPKHHPDVTYVKKVRTMRMHLFTALQLLCLALLWAVMSTAASLAFPFILILTVPLRMVVLTRIFTEREMKCLDANEAEPVFDECEGVDEYNEMPMPV
uniprot
proteins
function
FUNCTION: Sodium-independent anion exchanger which mediates the electroneutral exchange of chloride for bicarbonate ions across the cell membrane (PubMed:12958022, PubMed:18971331, PubMed:23341620, PubMed:2371270, PubMed:24515893). Plays an important role in osteoclast differentiation and function (PubMed:18971331, PubMed:23341620). Regulates bone resorption and calpain-dependent actin cytoskeleton organization in osteoclasts via anion exchange-dependent control of pH (PubMed:23341620). Essential for intracellular pH regulation in CD8(+) T-cells upon CD3 stimulation, modulating CD8(+) T-cell responses (PubMed:24515893). {ECO:0000269|PubMed:12958022, ECO:0000269|PubMed:18971331, ECO:0000269|PubMed:23341620, ECO:0000269|PubMed:2371270, ECO:0000269|PubMed:24515893}.; FUNCTION: [Isoform A]: Plays a critical role in male fertility and spermiogenesis. {ECO:0000269|PubMed:14673081}.; FUNCTION: [Isoform B1]: Plays a critical role in male fertility and spermiogenesis. {ECO:0000269|PubMed:14673081}.; FUNCTION: [Isoform B2]: Plays a critical role in male fertility and spermiogenesis. {ECO:0000269|PubMed:14673081}.
uniprot
proteins
mass_dalton
136814
uniprot
proteins
mutagenesis
MUTAGEN 1056; /note="R->A: Loss of activity but no effect on localization to basolateral cell membrane."; /evidence="ECO:0000269|PubMed:23341620
uniprot
proteins
protein_family
Anion exchanger (TC 2.A.31) family
uniprot
proteins
pubmed
11006093
uniprot
proteins
pubmed
12958022
uniprot
proteins
pubmed
14673081
uniprot
proteins
pubmed
18971331
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23341620
uniprot
proteins
pubmed
2371270
uniprot
proteins
pubmed
24515893
uniprot
proteins
pubmed
3182834
uniprot
proteins
sequence_length
1237
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:P04920}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:12958022, ECO:0000269|PubMed:18971331, ECO:0000269|PubMed:23341620, ECO:0000269|PubMed:2371270}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 704..727; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 733..770; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 790..812; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 822..843; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 897..914; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 930..950; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 984..1006; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1032..1053; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1087..1132; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1159..1195; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins