SPIRE1
entrez
56907
canonical
uniprot
Q08AE8
canonical
ensembl
ENSG00000134278
resolver
ensp
ENSP00000309661
resolver
ensp
ENSP00000387226
resolver
ensp
ENSP00000387266
resolver
ensp
ENSP00000407050
resolver
ensp
ENSP00000596450
resolver
ensp
ENSP00000784754
resolver
enst
ENST00000309836
resolver
genesymbol
SPIRE1
resolver
genesymbol_syn
KIAA1135
resolver
genesymbol_syn
SPIR1
resolver
hgnc
HGNC:30622
resolver
uniprot
A8K2B5
resolver
uniprot
J3KNG6
resolver
uniprot
J3KQ50
resolver
uniprot
J3KQR5
resolver
uniprot
Q1RMD4
resolver
uniprot
Q8NDP1
resolver
uniprot
Q9NQ71
resolver
uniprot
Q9ULT4
resolver
uniprot_entry
J3KNG6_HUMAN
resolver
uniprot_entry
SPIR1_HUMAN
resolver
uniprot_sec
A8K2B5
resolver
uniprot_sec
J3KQ50
resolver
uniprot_sec
J3KQR5
resolver
uniprot_sec
Q1RMD4
resolver
uniprot_sec
Q8NDP1
resolver
uniprot_sec
Q9NQ71
resolver
uniprot_sec
Q9ULT4
resolver
amino_acid_sequence
MAQAAGPAGGGEPRTEAVGGEGPREPGAAGGAAGGSRDALSLEEILRLYNQPINEEQAWAVCYQCCGSLRAAARRRQPRHRVRSAAQIRVWRDGAVTLAPAADDAGEPPPVAGKLGYSQCMETEVIESLGIIIYKALDYGLKENEERELSPPLEQLIDHMANTVEADGSNDEGYEAAEEGLGDEDEKRKISAIRSYRDVMKLCAAHLPTESDAPNHYQAVCRALFAETMELHTFLTKIKSAKENLKKIQEMEKSDESSTDLEELKNADWARFWVQVMRDLRNGVKLKKVQERQYNPLPIEYQLTPYEMLMDDIRCKRYTLRKVMVNGDIPPRLKKSAHEIILDFIRSRPPLNPVSARKLKPTPPRPRSLHERILEEIKAERKLRPVSPEEIRRSRLAMRPLSMSYSFDLSDVTTPESTKNLVESSMVNGGLTSQTKENGLSTSQQVPAQRKKLLRAPTLAELDSSESEEETLHKSTSSSSVSPSFPEEPVLEAVSTRKKPPKFLPISSTPQPERRQPPQRRHSIEKETPTNVRQFLPPSRQSSRSLEEFCYPVECLALTVEEVMHIRQVLVKAELEKYQQYKDIYTALKKGKLCFCCRTRRFSFFTWSYTCQFCKRPVCSQCCKKMRLPSKPYSTLPIFSLGPSALQRGESSMRSEKPSTAHHRPLRSIARFSSKSKSMDKSDEELQFPKELMEDWSTMEVCVDCKKFISEIISSSRRSLVLANKRARLKRKTQSFYMSSPGPSEYCPSERTISEI
uniprot
proteins
function
FUNCTION: Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:11747823, PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:11747823). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). In addition, promotes innate immune signaling downstream of dsRNA sensing (PubMed:35148361). Mechanistically, contributes to IRF3 phosphorylation and activation downstream of MAVS and upstream of TBK1 (PubMed:35148361). {ECO:0000269|PubMed:11747823, ECO:0000269|PubMed:21620703, ECO:0000269|PubMed:26287480, ECO:0000269|PubMed:35148361}.
uniprot
proteins
mass_dalton
85544
uniprot
proteins
mutagenesis
MUTAGEN 131; /note="I->K: Strongly reduces interaction with FMN2."; /evidence="ECO:0000269|PubMed:21730168"; MUTAGEN 134; /note="Y->K: Abolishes interaction with FMN2."; /evidence="ECO:0000269|PubMed:21705804"; MUTAGEN 138; /note="D->N: Abolishes interaction with FMN2."; /evidence="ECO:0000269|PubMed:21705804, ECO:0000269|PubMed:21730168"; MUTAGEN 146; /note="E->A,K: Abolishes interaction with FMN2."; /evidence="ECO:0000269|PubMed:21730168
uniprot
proteins
protein_family
Spire family
uniprot
proteins
pubmed
10574461
uniprot
proteins
pubmed
11747823
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21620703
uniprot
proteins
pubmed
21705804
uniprot
proteins
pubmed
21730168
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26287480
uniprot
proteins
pubmed
35148361
uniprot
proteins
sequence_length
756
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11747823}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11747823}. Cell membrane {ECO:0000269|PubMed:11747823}; Peripheral membrane protein {ECO:0000269|PubMed:11747823}; Cytoplasmic side {ECO:0000269|PubMed:11747823}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q52KF3}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q52KF3}; Cytoplasmic side {ECO:0000250|UniProtKB:Q52KF3}. Note=Detected at the cleavage furrow during asymmetric oocyte division and polar body extrusion (By similarity). Punctate spots in perinuclear region and cytoplasm, colocalized with Rab11 (By similarity). {ECO:0000250|UniProtKB:Q52KF3}.
uniprot
proteins