PDLIM7
entrez
9260
canonical
uniprot
Q9NR12
canonical
ensembl
ENSG00000196923
resolver
ensp
ENSP00000347776
resolver
ensp
ENSP00000348099
resolver
ensp
ENSP00000352964
resolver
genesymbol
PDLIM7
resolver
genesymbol_syn
ENIGMA
resolver
hgnc
HGNC:22958
resolver
uniprot
Q14250
resolver
uniprot
Q5XG82
resolver
uniprot
Q6NVZ5
resolver
uniprot
Q96C91
resolver
uniprot
Q9BXB8
resolver
uniprot
Q9BXB9
resolver
uniprot_entry
PDLI7_HUMAN
resolver
uniprot_sec
Q14250
resolver
uniprot_sec
Q5XG82
resolver
uniprot_sec
Q6NVZ5
resolver
uniprot_sec
Q96C91
resolver
uniprot_sec
Q9BXB8
resolver
uniprot_sec
Q9BXB9
resolver
amino_acid_sequence
MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGSLTHIEAQNKIRACGERLSLGLSRAQPVQSKPQKASAPAADPPRYTFAPSVSLNKTARPFGAPPPADSAPQQNGQPLRPLVPDASKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEFMQDPDEEHLKKSSQVPRTEAPAPASSTPQEPWPGPTAPSPTSRPPWAVDPAFAERYAPDKTSTVLTRHSQPATPTPLQSRTSIVQAAAGGVPGGGSNNGKTPVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCKSHAFSHV
uniprot
proteins
function
FUNCTION: May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity). {ECO:0000250, ECO:0000269|PubMed:11874232, ECO:0000269|PubMed:7929196}.
uniprot
proteins
mass_dalton
49845
uniprot
proteins
mutagenesis
MUTAGEN 15..16; /note="GF->AA: Loss of binding to TPM2."; /evidence="ECO:0000269|PubMed:10359609"; MUTAGEN 63; /note="H->A: Loss of binding to TPM2."; /evidence="ECO:0000269|PubMed:10359609
uniprot
proteins
pubmed
10359609
uniprot
proteins
pubmed
11874232
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
7929196
uniprot
proteins
pubmed
8940095
uniprot
proteins
pubmed
9528800
uniprot
proteins
sequence_length
457
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Colocalizes with RET to the cell periphery and in some cytoskeletal components. Colocalizes with TPM2 near the Z line in muscle. Colocalizes with TBX4 and TBX5 to actin filaments (By similarity). {ECO:0000250}.
uniprot
proteins