Spp1
entrez
20750
canonical
uniprot
P10923
canonical
ensembl
ENSMUSG00000029304
resolver
ensp
ENSMUSP00000031243
resolver
ensp
ENSMUSP00000084043
resolver
ensp
ENSMUSP00000108367
resolver
ensp
ENSMUSP00000108368
resolver
enst
ENSMUST00000031243
resolver
enst
ENSMUST00000086833
resolver
enst
ENSMUST00000112747
resolver
enst
ENSMUST00000112748
resolver
genesymbol
Spp1
resolver
genesymbol_syn
Eta-1
resolver
genesymbol_syn
OPN
resolver
genesymbol_syn
Op
resolver
genesymbol_syn
Spp-1
resolver
uniprot
F8WIP8
resolver
uniprot
P19008
resolver
uniprot
Q3UBR1
resolver
uniprot
Q547B5
resolver
uniprot
Q91VH4
resolver
uniprot_entry
F8WIP8_MOUSE
resolver
uniprot_entry
OSTP_MOUSE
resolver
uniprot_entry
Q3UBR1_MOUSE
resolver
uniprot_entry
Q547B5_MOUSE
resolver
uniprot_sec
P19008
resolver
uniprot_sec
Q91VH4
resolver
amino_acid_sequence
MRLAVICFCLFGIASSLPVKVTDSGSSEEKLYSLHPDPIATWLVPDPSQKQNLLAPQNAVSSEEKDDFKQETLPSNSNESHDHMDDDDDDDDDDGDHAESEDSVDSDESDESHHSDESDETVTASTQADTFTPIVPTVDVPNGRGDSLAYGLRSKSRSFQVSDEQYPDATDEDLTSHMKSGESKESLDVIPVAQLLSMPSDQDNNGKGSHESSQLDEPSLETHRLEHSKESQESADQSDVIDSQASSKASLEHQSHKFHSHKDKLVLDPKSKEDDRYLKFRISHELESSSSEVN
uniprot
proteins
function
FUNCTION: Major non-collagenous bone protein that binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. {ECO:0000250|UniProtKB:P31096}.; FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity. {ECO:0000269|PubMed:10657301, ECO:0000269|PubMed:2351930}.
uniprot
proteins
mass_dalton
32459
uniprot
proteins
post_translational_modification
PTM: Extensively phosphorylated by FAM20C in the extracellular medium at multiple sites within the S-x-E/pS motif (By similarity). The phosphorylated form inhibits hydroxyapatite crystallization (PubMed:23427088). Dephosphorylation via a mechanism involving ALPL/TNAP promotes hydroxyapatite crystallization (PubMed:23427088). {ECO:0000250|UniProtKB:P10451, ECO:0000269|PubMed:23427088}.; PTM: O-glycosylated. {ECO:0000250|UniProtKB:P10451}.; PTM: Forms covalent cross-links mediated by transglutaminase TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers, increasing its collagen binding properties. {ECO:0000250|UniProtKB:P31096}.
uniprot
proteins
protein_family
Osteopontin family
uniprot
proteins
pubmed
10657301
uniprot
proteins
pubmed
1414495
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22654117
uniprot
proteins
pubmed
23427088
uniprot
proteins
pubmed
2351930
uniprot
proteins
pubmed
2387863
uniprot
proteins
pubmed
2722855
uniprot
proteins
pubmed
2726465
uniprot
proteins
pubmed
2787378
uniprot
proteins
sequence_length
294
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P10451}.
uniprot
proteins