Dcst2
entrez
329702
canonical
uniprot
A0A140LIJ0
canonical
ensembl
ENSMUSG00000109293
resolver
ensp
ENSMUSP00000146838
resolver
ensp
ENSMUSP00000355313
resolver
enst
ENSMUST00000208216
resolver
genesymbol
Dcst2
resolver
uniprot_entry
DCST2_MOUSE
resolver
amino_acid_sequence
MEEGSSTARAVVRSTCGFTVGLSLATAFGLLELLGEGHSPFGCLVTTVTLAAFLSLGMGFSRQVRVSVLLLLPQAFSKQSRLLLLVASFGLVLQGPCANTLQNFTRASEAVACGAELALNQTAEMLERAKQPLISALSKIKAIAQKAKVVGDRIRKFFRSIIDAVKHIARCLQNVWYWLLHIGDMCNSELGNPYSKCTQVFDDAKIHCMKVVSGFPHLCYALLPYKLLVCGLASLVQKFCVLPSYLEFFLRTVIRTPVMKLLGKLRREFEFNMTATHYFSVDLNSSRSLSQVALDLQEAVSMKLYTAREALSLMGYTMPLLIGFLYIQALCYRYYYLNSDKFDNVYITRRFLDMEAVRSLAGMPTVLPLSSHEAKHYIQPDSMFLSQREQMFYTLEIFNLTRHLLIMLLLVFLDYGVFWLLDLARYHLQGEIVARSPVVVSISVEGSGYSGNIYRDLASAFDVMQQGNVSVLSPRCTLHPSEPDAKGYIVIGTMYGLCFFVTLFGSYVSRLRRAICASYYPSREQERITYLYNMLLSHRTNITATVQRAVRRRSADQGQMNILQVLAIRLPFLRPLLGPFSLQQSYCMGCGEPEDKGGMENFVSCSTPGCRGLYCPTCFRLLNNTCSVCSAPLSNQGHLDLELDSSDEESPQLWLAAARRKAPEQELKLRQQLQEALGTNLSDKSTSKPERAGNRNQDRKQ
uniprot
proteins
function
FUNCTION: Essential sperm cell-surface protein required for sperm-egg fusion and fertilization. {ECO:0000269|PubMed:33871360, ECO:0000269|PubMed:35393517}.
uniprot
proteins
mass_dalton
78574
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
33871360
uniprot
proteins
pubmed
35393517
uniprot
proteins
sequence_length
701
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000269|PubMed:35393517}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes in the anterior acrosome before the acrosome reaction and then translocates to the equatorial segment in acrosome-reacted sperm. {ECO:0000269|PubMed:35393517}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..35; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 40..60; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 82..102; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 215..235; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 310..330; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 404..424; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 488..508; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins