TAF10
entrez
6881
canonical
uniprot
Q12962
canonical
ensembl
ENSG00000166337
resolver
ensp
ENSP00000299424
resolver
enst
ENST00000299424
resolver
genesymbol
TAF10
resolver
genesymbol_syn
TAF2A
resolver
genesymbol_syn
TAF2H
resolver
genesymbol_syn
TAFII30
resolver
hgnc
HGNC:11543
resolver
uniprot
O00703
resolver
uniprot
Q13175
resolver
uniprot
Q6FH13
resolver
uniprot_entry
TAF10_HUMAN
resolver
uniprot_sec
O00703
resolver
uniprot_sec
Q13175
resolver
uniprot_sec
Q6FH13
resolver
amino_acid_sequence
MSCSGSGADPEAAPASAASAPGPAPPVSAPAALPSSTAAENKASPAGTAGGPGAGAAAGGTGPLAARAGEPAERRGAAPVSAGGAAPPEGAISNGVYVLPSAANGDVKPVVSSTPLVDFLMQLEDYTPTIPDAVTGYYLNRAGFEASDPRIIRLISLAAQKFISDIANDALQHCKMKGTASGSSRSKSKDRKYTLTMEDLTPALSEYGINVKKPHYFT
uniprot
proteins
function
FUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). TAF10 is also component of the PCAF histone acetylase complex, the TATA-binding protein-free TAF complex (TFTC) and the STAGA transcription coactivator-HAT complex (PubMed:10373431, PubMed:11564863, PubMed:12601814, PubMed:18206972, PubMed:9885574). May regulate cyclin E expression (By similarity). {ECO:0000250|UniProtKB:Q8K0H5, ECO:0000269|PubMed:10373431, ECO:0000269|PubMed:11564863, ECO:0000269|PubMed:12601814, ECO:0000269|PubMed:18206972, ECO:0000269|PubMed:33795473, ECO:0000269|PubMed:9885574}.
uniprot
proteins
mass_dalton
21711
uniprot
proteins
mutagenesis
MUTAGEN 189; /note="K->Q: Abolishes methylation. Does not affect interaction with LOXL2 but greatly reduces deamination by LOXL2."; /evidence="ECO:0000269|PubMed:15099517, ECO:0000269|PubMed:25959397
uniprot
proteins
post_translational_modification
PTM: Monomethylated at Lys-189 by SETD7, leading to increased affinity for RNA polymerase II. {ECO:0000269|PubMed:15099517, ECO:0000269|PubMed:16415881}.; PTM: Lysine deamination at Lys-189 to form allysine is mediated by LOXL2. Allysine formation by LOXL2 results in release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription. {ECO:0000269|PubMed:25959397}.
uniprot
proteins
protein_family
TAF10 family
uniprot
proteins
pubmed
10373431
uniprot
proteins
pubmed
11438666
uniprot
proteins
pubmed
11564863
uniprot
proteins
pubmed
12601814
uniprot
proteins
pubmed
15099517
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16415881
uniprot
proteins
pubmed
18206972
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25959397
uniprot
proteins
pubmed
33795473
uniprot
proteins
pubmed
7729427
uniprot
proteins
pubmed
7923369
uniprot
proteins
pubmed
8530084
uniprot
proteins
pubmed
9674425
uniprot
proteins
pubmed
9885574
uniprot
proteins
sequence_length
218
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11564863, ECO:0000269|PubMed:25959397, ECO:0000269|PubMed:9674425}.
uniprot
proteins