FIGNL1
entrez
63979
canonical
uniprot
Q6PIW4
canonical
ensembl
ENSG00000132436
resolver
ensp
ENSP00000349356
resolver
ensp
ENSP00000378924
resolver
ensp
ENSP00000399997
resolver
ensp
ENSP00000483126
resolver
ensp
ENSP00000483543
resolver
ensp
ENSP00000571265
resolver
ensp
ENSP00000571266
resolver
ensp
ENSP00000571267
resolver
ensp
ENSP00000571270
resolver
ensp
ENSP00000571271
resolver
ensp
ENSP00000571272
resolver
ensp
ENSP00000571274
resolver
ensp
ENSP00000571276
resolver
ensp
ENSP00000571279
resolver
ensp
ENSP00000593646
resolver
genesymbol
FIGNL1
resolver
hgnc
HGNC:13286
resolver
uniprot
B3KNH6
resolver
uniprot
D3DVM6
resolver
uniprot
Q86V18
resolver
uniprot
Q8ND59
resolver
uniprot
Q9H8P1
resolver
uniprot
Q9H917
resolver
uniprot_entry
B3KNH6_HUMAN
resolver
uniprot_entry
FIGL1_HUMAN
resolver
uniprot_sec
D3DVM6
resolver
uniprot_sec
Q86V18
resolver
uniprot_sec
Q8ND59
resolver
uniprot_sec
Q9H8P1
resolver
uniprot_sec
Q9H917
resolver
activity_regulation
ACTIVITY REGULATION: Ability to mediate disassembly of RAD51 filaments is inhibited by SWSAP1 (PubMed:30926776). Ability to mediate disassembly of RAD51 filaments is inhibited by BRCA2 (PubMed:37515771, PubMed:41166468). {ECO:0000269|PubMed:30926776, ECO:0000269|PubMed:37515771, ECO:0000269|PubMed:41166468}.
uniprot
proteins
amino_acid_sequence
MQTSSSRSVHLSEWQKNYFAITSGICTGPKADAYRAQILRIQYAWANSEISQVCATKLFKKYAEKYSAIIDSDNVESGLNNYAENILTLAGSQQTDSDKWQSGLSINNVFKMSSVQKMMQAGKKFKDSLLEPALASVVIHKEATVFDLPKFSVCGSSQESDSLPNSAHDRDRTQDFPESNRLKLLQNAQPPMVTNTARTCPTFSAPVGESATAKFHVTPLFGNVKKENHSSAKENIGLNVFLSNQSCFPAACENPQRKSFYGSGTIDALSNPILNKACSKTEDNGPKEDSSLPTFKTAKEQLWVDQQKKYHQPQRASGSSYGGVKKSLGASRSRGILGKFVPPIPKQDGGEQNGGMQCKPYGAGPTEPAHPVDERLKNLEPKMIELIMNEIMDHGPPVNWEDIAGVEFAKATIKEIVVWPMLRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRGDGEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARRRLVKRLYIPLPEASARKQIVINLMSKEQCCLSEEEIEQIVQQSDAFSGADMTQLCREASLGPIRSLQTADIATITPDQVRPIAYIDFENAFRTVRPSVSPKDLELYENWNKTFGCGK
uniprot
proteins
disease_involvement
DISEASE: Note=Ovarian dysgenesis (PubMed:37740949). An autosomal recessive form of ovarian dysgenesis, a disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, dysgenic ovaries and hypergonadotropic hypogonadism as a result of streak gonads (PubMed:37740949). The disease is caused by variants affecting the gene represented in this entry (PubMed:37740949). {ECO:0000269|PubMed:37740949}.
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: ATPase that maintains genome stability by acting as a key regulator of DNA double-strand break (DSB) repair via homologous recombination (HR) (PubMed:23754376, PubMed:37256941, PubMed:37347663, PubMed:37515771, PubMed:37556550, PubMed:38286805, PubMed:38597669, PubMed:39636933, PubMed:41166468). Regulates HR by mediating disassembly of RAD51 filaments from DNA and chromatin, thereby preventing DNA damage-independent RAD51 loading and persistent DNA accumulation of RAD51 recombinases (PubMed:37256941, PubMed:37347663, PubMed:37515771, PubMed:37556550, PubMed:38286805, PubMed:38597669, PubMed:39636933, PubMed:41166468). Also regulates HR during meiosis by mediating dissociation of DMC1 filaments from DNA (By similarity). May regulate osteoblast proliferation and differentiation (By similarity). {ECO:0000250|UniProtKB:Q8BPY9, ECO:0000269|PubMed:23754376, ECO:0000269|PubMed:37256941, ECO:0000269|PubMed:37347663, ECO:0000269|PubMed:37515771, ECO:0000269|PubMed:37556550, ECO:0000269|PubMed:38286805, ECO:0000269|PubMed:38597669, ECO:0000269|PubMed:39636933, ECO:0000269|PubMed:41166468}.
uniprot
proteins
mass_dalton
74077
uniprot
proteins
mutagenesis
MUTAGEN 295; /note="F->E: Reduces interaction with RAD51 and inhibits HR-mediated DNA repair. Does not affect interaction with FIRRM. Strongly reduce, but does abolish, interaction with RAD51; when associated with E-340."; /evidence="ECO:0000269|PubMed:23754376, ECO:0000269|PubMed:37556550"; MUTAGEN 340; /note="F->E: Reduces weakly interaction with RAD51. Strongly reduce, but does abolish, interaction with RAD51; when associated with E-295."; /evidence="ECO:0000269|PubMed:23754376"; MUTAGEN 447; /note="K->A: Inhibits HR-mediated DNA repair. Abolished ATPase activity without affecting interaction with FIRRM; when associated with A-500."; /evidence="ECO:0000269|PubMed:23754376, ECO:0000269|PubMed:37556550"; MUTAGEN 500; /note="D->A: Inhibits HR-mediated DNA repair. Abolished ATPase activity without affecting interaction with FIRRM; when associated with A-447."; /evidence="ECO:0000269|PubMed:23754376, ECO:0000269|PubMed:37556550
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15707573
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23754376
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
29608566
uniprot
proteins
pubmed
30926776
uniprot
proteins
pubmed
37256941
uniprot
proteins
pubmed
37347663
uniprot
proteins
pubmed
37515771
uniprot
proteins
pubmed
37556550
uniprot
proteins
pubmed
37740949
uniprot
proteins
pubmed
38286805
uniprot
proteins
pubmed
38597669
uniprot
proteins
pubmed
39636933
uniprot
proteins
pubmed
41166468
uniprot
proteins
sequence_length
674
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:23754376, ECO:0000269|PubMed:41166468}. Nucleus {ECO:0000269|PubMed:15707573, ECO:0000269|PubMed:23754376}. Cytoplasm {ECO:0000269|PubMed:15707573}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8BPY9}. Note=Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. {ECO:0000269|PubMed:23754376}.
uniprot
proteins