KCNAB1
entrez
7881
canonical
uniprot
Q14722
canonical
ensembl
ENSG00000169282
resolver
ensp
ENSP00000305858
resolver
ensp
ENSP00000374285
resolver
ensp
ENSP00000374287
resolver
ensp
ENSP00000418956
resolver
ensp
ENSP00000419952
resolver
enst
ENST00000389634
resolver
enst
ENST00000389636
resolver
genesymbol
KCNAB1
resolver
genesymbol_syn
KCNA1B
resolver
hgnc
HGNC:6228
resolver
uniprot
A8K9H8
resolver
uniprot
A8KAD4
resolver
uniprot
B3KPZ4
resolver
uniprot
B7Z435
resolver
uniprot
B7Z8E5
resolver
uniprot
F8W6V9
resolver
uniprot
F8W6W4
resolver
uniprot
Q13031
resolver
uniprot
Q13302
resolver
uniprot
Q16547
resolver
uniprot
Q5MJQ3
resolver
uniprot
Q6PI60
resolver
uniprot
Q99869
resolver
uniprot_entry
B7Z435_HUMAN
resolver
uniprot_entry
B7Z8E5_HUMAN
resolver
uniprot_entry
F8W6V9_HUMAN
resolver
uniprot_entry
F8W6W4_HUMAN
resolver
uniprot_entry
KCAB1_HUMAN
resolver
uniprot_entry
Q5MJQ3_HUMAN
resolver
uniprot_sec
A8K9H8
resolver
uniprot_sec
A8KAD4
resolver
uniprot_sec
B3KPZ4
resolver
uniprot_sec
Q13031
resolver
uniprot_sec
Q13302
resolver
uniprot_sec
Q16547
resolver
uniprot_sec
Q6PI60
resolver
uniprot_sec
Q99869
resolver
amino_acid_sequence
MLAARTGAAGSQISEENTKLRRQSGFSVAGKDKSPKKASENAKDSSLSPSGESQLRARQLALLREVEMNWYLKLCDLSSEHTTVCTTGMPHRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRASLKCYQWLKERIVSEEGRKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQVLPKMTSHVVNEIDNILRNKPYSKKDYRS
uniprot
proteins
ec_number
1.1.1.-
uniprot
proteins
function
FUNCTION: Regulatory subunit of the voltage-gated potassium (Kv) Shaker channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits (PubMed:17156368, PubMed:17540341, PubMed:19713757, PubMed:7499366, PubMed:7603988). The beta-1/KCNAB1 cytoplasmic subunit mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:9763623). Promotes the inactivation of Kv1.1/KCNA1, Kv1.2/KCNA2, Kv1.4/KCNA4, Kv1.5/KCNA5 and Kv1.6/KCNA6 alpha subunit-containing channels (PubMed:12077175, PubMed:12130714, PubMed:15361858, PubMed:17156368, PubMed:17540341, PubMed:19713757, PubMed:7499366, PubMed:7603988, PubMed:7649300, PubMed:7890764, PubMed:9763623). Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a variety of endogenous aldehydes and ketones (By similarity). The binding of NADPH is required for efficient down-regulation of potassium channel activity (PubMed:17540341). Oxidation of the bound NADPH restrains N-terminal domain from blocking the channel, thereby decreasing N-type inactivation of potassium channel activity (By similarity). {ECO:0000250|UniProtKB:P63144, ECO:0000269|PubMed:12077175, ECO:0000269|PubMed:12130714, ECO:0000269|PubMed:15361858, ECO:0000269|PubMed:17156368, ECO:0000269|PubMed:17540341, ECO:0000269|PubMed:19713757, ECO:0000269|PubMed:7499366, ECO:0000269|PubMed:7603988, ECO:0000269|PubMed:7649300, ECO:0000269|PubMed:7890764, ECO:0000269|PubMed:9763623}.; FUNCTION: [Isoform KvB1.2]: Isoform KvB1.2 shows no effect on KCNA1, KCNA2 or KCNB1. {ECO:0000269|PubMed:7890032, ECO:0000269|PubMed:7890764}.
uniprot
proteins
mass_dalton
46563
uniprot
proteins
mutagenesis
MUTAGEN 307; /note="Y->F: Reduces affinity for NADPH."; /evidence="ECO:0000269|PubMed:17540341"; MUTAGEN 316; /note="R->E: Nearly abolishes NADPH binding."; /evidence="ECO:0000269|PubMed:17540341
uniprot
proteins
protein_family
Shaker potassium channel beta subunit family
uniprot
proteins
pubmed
12077175
uniprot
proteins
pubmed
12130714
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15361858
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17156368
uniprot
proteins
pubmed
17540341
uniprot
proteins
pubmed
19713757
uniprot
proteins
pubmed
7499366
uniprot
proteins
pubmed
7603988
uniprot
proteins
pubmed
7649300
uniprot
proteins
pubmed
7890032
uniprot
proteins
pubmed
7890764
uniprot
proteins
pubmed
8938711
uniprot
proteins
pubmed
9763623
uniprot
proteins
sequence_length
419
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17540341}. Membrane {ECO:0000250|UniProtKB:P63144}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:17540341}; Peripheral membrane protein {ECO:0000269|PubMed:17540341}; Cytoplasmic side {ECO:0000269|PubMed:17540341}. Note=Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits. {ECO:0000269|PubMed:17540341}.
uniprot
proteins