Cyren
entrez
78412
canonical
uniprot
Q8BHZ5
canonical
ensembl
ENSMUSG00000046806
resolver
ensp
ENSMUSP00000053349
resolver
ensp
ENSMUSP00000110658
resolver
ensp
ENSMUSP00000110659
resolver
ensp
ENSMUSP00000284044
resolver
genesymbol
Cyren
resolver
genesymbol_syn
Mri
resolver
uniprot
Q8K0Y5
resolver
uniprot_entry
CYREN_MOUSE
resolver
uniprot_sec
Q8K0Y5
resolver
amino_acid_sequence
METLKSKTKTRVLPSWMTAPVDERKVVSVKTATRKQTAAWAQRVGAATRAPATETVYCMNEAEMVDVALGILIEGRKQEKPWEQRSLEATDKLQLSPPCSSSPGSSSEEEDSRISSLAPGLSPPRGPEASDSPCSRSPEEEKEEEDALKYVREIFFS
uniprot
proteins
function
FUNCTION: Cell-cycle-specific regulator of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair, which can act both as an activator or inhibitor of NHEJ, depending on the cell cycle phase (PubMed:30017584). Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present (By similarity). Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination (By similarity). Acts via interaction with XRCC5/Ku80 and XRCC6/Ku70 (By similarity). In contrast, acts as an activator of NHEJ during G1 phase of the cell cycle: promotes classical NHEJ in G1 phase cells via multivalent interactions that increase the affinity of DNA damage response proteins for DSB-associated chromatin (PubMed:30017584). Also involved in immunoglobulin V(D)J recombination (PubMed:30017584, PubMed:31795137). May also act as an indirect regulator of proteasome (By similarity). {ECO:0000250|UniProtKB:Q09HN1, ECO:0000250|UniProtKB:Q9BWK5, ECO:0000269|PubMed:30017584, ECO:0000269|PubMed:31795137}.
uniprot
proteins
mass_dalton
17287
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
30017584
uniprot
proteins
pubmed
31795137
uniprot
proteins
pubmed
32355287
uniprot
proteins
sequence_length
157
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BWK5}. Nucleus {ECO:0000250|UniProtKB:Q9BWK5}. Chromosome {ECO:0000269|PubMed:30017584}. Note=Nuclear localization may depend upon interaction with XRCC5/Ku80 and XRCC6/Ku70 heterodimer (By similarity). Localizes to DNA damage sites (PubMed:30017584). {ECO:0000250|UniProtKB:Q9BWK5, ECO:0000269|PubMed:30017584}.
uniprot
proteins