Slc6a3
entrez
24898
canonical
uniprot
P23977
canonical
ensembl
ENSRNOG00000017302
resolver
ensembl
ENSRNOG00055003028
resolver
ensembl
ENSRNOG00060025890
resolver
ensembl
ENSRNOG00065018573
resolver
ensp
ENSRNOP00000047272
resolver
ensp
ENSRNOP00055003484
resolver
ensp
ENSRNOP00060037164
resolver
ensp
ENSRNOP00065024841
resolver
enst
ENSRNOT00000040291
resolver
enst
ENSRNOT00055004713
resolver
enst
ENSRNOT00060044814
resolver
enst
ENSRNOT00065031192
resolver
genesymbol
Slc6a3
resolver
uniprot_entry
SC6A3_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by mazindol, cocaine, desipramine, GBR 12783 dihydrochloride, GBR 12909 dihydrochloride and nomifensine (PubMed:1502198, PubMed:1765147, PubMed:1948034, PubMed:1948035). Inhibited by zinc ions (By similarity). {ECO:0000250|UniProtKB:Q01959, ECO:0000269|PubMed:1502198, ECO:0000269|PubMed:1765147, ECO:0000269|PubMed:1948034, ECO:0000269|PubMed:1948035}.
uniprot
proteins
amino_acid_sequence
MSKSKCSVGPMSSVVAPAKESNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEAQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHASNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDHQLVDRGEVRQFTLRHWLLL
uniprot
proteins
function
FUNCTION: Mediates sodium- and chloride-dependent transport of dopamine (PubMed:1502198, PubMed:1765147, PubMed:1948034, PubMed:1948035, PubMed:8125921). Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (PubMed:8125921). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity). {ECO:0000250|UniProtKB:Q61327, ECO:0000269|PubMed:1502198, ECO:0000269|PubMed:1765147, ECO:0000269|PubMed:1948034, ECO:0000269|PubMed:1948035, ECO:0000269|PubMed:8125921}.
uniprot
proteins
mass_dalton
68746
uniprot
proteins
mutagenesis
MUTAGEN 79; /note="D->A,G,E: Significant loss of dopamine transport activity."; /evidence="ECO:0000269|PubMed:1502198"; MUTAGEN 356; /note="S->A: Reduced dopamine transport activity; when associated with A-359."; /evidence="ECO:0000269|PubMed:1502198"; MUTAGEN 356; /note="S->G: Reduced dopamine transport activity; when associated with G-359."; /evidence="ECO:0000269|PubMed:1502198"; MUTAGEN 359; /note="S->A: Reduced dopamine transport activity; when associated with A-356."; /evidence="ECO:0000269|PubMed:1502198"; MUTAGEN 359; /note="S->G: Reduced dopamine transport activity; when associated with G-356."; /evidence="ECO:0000269|PubMed:1502198"; MUTAGEN 403; /note="S->A: No effect on dopamine transport activity; when associated with G-404."; /evidence="ECO:0000269|PubMed:1502198"; MUTAGEN 404; /note="S->A: No effect on dopamine transport activity; when associated with G-403."; /evidence="ECO:0000269|PubMed:1502198
uniprot
proteins
protein_family
SLC6A3 subfamily
uniprot
proteins
protein_family
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
uniprot
proteins
pubmed
1502198
uniprot
proteins
pubmed
1765147
uniprot
proteins
pubmed
1948034
uniprot
proteins
pubmed
1948035
uniprot
proteins
pubmed
32963038
uniprot
proteins
pubmed
8125921
uniprot
proteins
sequence_length
619
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q01959}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q01959}. Cell projection, neuron projection {ECO:0000269|PubMed:32963038}. Cell projection, axon {ECO:0000250|UniProtKB:Q01959}. Note=Localizes to neurite tips in neuronal cells (PubMed:32963038). Colocalizes with SEPTIN4 at axon terminals, especially at the varicosities (By similarity). {ECO:0000250|UniProtKB:Q61327, ECO:0000269|PubMed:32963038}.
uniprot
proteins
transmembrane_region
TRANSMEM 57..95; /note="Discontinuously helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q01959"; TRANSMEM 96..127; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q01959"; TRANSMEM 128..171; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q01959"; TRANSMEM 236..255; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q01959"; TRANSMEM 256..286; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q01959"; TRANSMEM 306..334; /note="Discontinuously helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q01959"; TRANSMEM 335..375; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q01959"; TRANSMEM 400..441; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q01959"; TRANSMEM 442..465; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q01959"; TRANSMEM 466..498; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q01959"; TRANSMEM 516..541; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q01959"; TRANSMEM 553..582; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:Q01959
uniprot
proteins