Dut
entrez
497778
canonical
uniprot
P70583
canonical
ensembl
ENSRNOG00000007221
resolver
ensembl
ENSRNOG00055005141
resolver
ensembl
ENSRNOG00060019051
resolver
ensembl
ENSRNOG00065012683
resolver
ensp
ENSRNOP00000009549
resolver
ensp
ENSRNOP00000112289
resolver
ensp
ENSRNOP00055006214
resolver
ensp
ENSRNOP00060026988
resolver
ensp
ENSRNOP00065015912
resolver
enst
ENSRNOT00000009549
resolver
enst
ENSRNOT00000137124
resolver
enst
ENSRNOT00055008243
resolver
enst
ENSRNOT00060032993
resolver
enst
ENSRNOT00065020675
resolver
genesymbol
Dut
resolver
genesymbol_syn
Dutp
resolver
uniprot
A0ABK0M2K9
resolver
uniprot_entry
A0ABK0M2K9_RAT
resolver
uniprot_entry
DUT_RAT
resolver
amino_acid_sequence
MPLLCALLRSRLQPSLLRSLTLTSAQSLSCGGSRGVRTWSARTGPGACADPAVSVSKRARAEDDASLRFVRLSEHATAPTRGSARAAGYDLYSAYDYTIPSMEKALVKTDIQIAVPSGCYGRVAPRSGLAVKHFIDVGAGVIDEDYRGNVGVVLFNFGKEKFEVKKGDRIAQLICERILYPDLEEVQTLDNTERGSGGFGSTGKN
uniprot
proteins
ec_number
3.6.1.23
uniprot
proteins
function
FUNCTION: Catalyzes the cleavage of 2'-deoxyuridine 5'-triphosphate (dUTP) into 2'-deoxyuridine 5'-monophosphate (dUMP) and inorganic pyrophosphate and through its action efficiently prevents uracil misincorporation into DNA and at the same time provides dUMP, the substrate for de novo thymidylate biosynthesis (By similarity). Inhibits peroxisome proliferator-activated receptor (PPAR) activity by binding of its N-terminal to PPAR, preventing the latter's dimerization with retinoid X receptor (PubMed:8910358). Essential for embryonic development (By similarity). {ECO:0000250|UniProtKB:P33316, ECO:0000250|UniProtKB:Q9CQ43, ECO:0000269|PubMed:8910358}.
uniprot
proteins
mass_dalton
22003
uniprot
proteins
pathway_participation
PATHWAY: Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2. {ECO:0000250|UniProtKB:P33316}.
uniprot
proteins
protein_family
DUTPase family
uniprot
proteins
pubmed
8910358
uniprot
proteins
sequence_length
205
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8910358}. Nucleus {ECO:0000269|PubMed:8910358}. Note=Binding to PPAR induces translocation to the nucleus. {ECO:0000269|PubMed:8910358}.
uniprot
proteins