CDK11B
entrez
984
canonical
uniprot
P21127
canonical
ensembl
ENSG00000248333
resolver
ensp
ENSP00000463048
resolver
ensp
ENSP00000464016
resolver
ensp
ENSP00000464036
resolver
ensp
ENSP00000485705
resolver
ensp
ENSP00000562933
resolver
ensp
ENSP00000562934
resolver
ensp
ENSP00000562936
resolver
ensp
ENSP00000601802
resolver
ensp
ENSP00000601803
resolver
genesymbol
CDK11B
resolver
genesymbol_syn
CDC2L1
resolver
genesymbol_syn
CDK11
resolver
genesymbol_syn
PITSLREA
resolver
hgnc
HGNC:1729
resolver
uniprot
B4DII1
resolver
uniprot
B7ZVY7
resolver
uniprot
J3KTL7
resolver
uniprot
J3QR29
resolver
uniprot
J3QR44
resolver
uniprot
O95265
resolver
uniprot
Q12817
resolver
uniprot
Q12818
resolver
uniprot
Q12819
resolver
uniprot
Q12820
resolver
uniprot
Q12822
resolver
uniprot
Q8N530
resolver
uniprot
Q9NZS5
resolver
uniprot
Q9UBJ0
resolver
uniprot
Q9UBQ1
resolver
uniprot
Q9UBR0
resolver
uniprot
Q9UNY2
resolver
uniprot
Q9UP57
resolver
uniprot
Q9UP58
resolver
uniprot
Q9UP59
resolver
uniprot_entry
B4DII1_HUMAN
resolver
uniprot_entry
CD11B_HUMAN
resolver
uniprot_sec
B7ZVY7
resolver
uniprot_sec
J3KTL7
resolver
uniprot_sec
J3QR29
resolver
uniprot_sec
J3QR44
resolver
uniprot_sec
O95265
resolver
uniprot_sec
Q12817
resolver
uniprot_sec
Q12818
resolver
uniprot_sec
Q12819
resolver
uniprot_sec
Q12820
resolver
uniprot_sec
Q12822
resolver
uniprot_sec
Q8N530
resolver
uniprot_sec
Q9NZS5
resolver
uniprot_sec
Q9UBJ0
resolver
uniprot_sec
Q9UBQ1
resolver
uniprot_sec
Q9UBR0
resolver
uniprot_sec
Q9UNY2
resolver
uniprot_sec
Q9UP57
resolver
uniprot_sec
Q9UP58
resolver
uniprot_sec
Q9UP59
resolver
activity_regulation
ACTIVITY REGULATION: Inactivated by phosphorylation at Thr-448 or Tyr-449 (PubMed:41100585). Activated by phosphorylation at Thr-595 (PubMed:41100585). Phosphorylated and activated by CDK7 in the CDK-activating kinase (CAK) complex, and reciprocally phosphorylating its activating kinase CDK7 (PubMed:41100585). CDK11 (CDK11A and/or CDK11B) is specifically inhibited by the anticancer agent OTS964 (PubMed:31511426, PubMed:36104565, PubMed:36327972). {ECO:0000250|UniProtKB:P06493, ECO:0000269|PubMed:31511426, ECO:0000269|PubMed:36104565, ECO:0000269|PubMed:36327972, ECO:0000269|PubMed:41100585}.
uniprot
proteins
amino_acid_sequence
MGDEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRGEEDDSLAIKPPQQMSRKEKAHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPGEARPAPAQKPAQLKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEEGTYGVVYRAKDKKTDEIVALKRLKMEKEKEGFPITSLREINTILKAQHPNIVTVREIVVGSNMDKIYIVMNYVEHDLKSLMETMKQPFLPGEVKTLMIQLLRGVKHLHDNWILHRDLKTSNLLLSHAGILKVGDFGLAREYGSPLKAYTPVVVTLWYRAPELLLGAKEYSTAVDMWSVGCIFGELLTQKPLFPGKSEIDQINKVFKDLGTPSEKIWPGYSELPAVKKMTFSEHPYNNLRKRFGALLSDQGFDLMNKFLTYFPGRRISAEDGLKHEYFRETPLPIDPSMFPTWPAKSEQQRVKRGTSPRPPEGGLGYSQLGDDDLKETGFHLTTTNQGASAAGPGFSLKF
uniprot
proteins
ec_number
2.7.11.22
uniprot
proteins
ec_number
2.7.11.23
uniprot
proteins
function
FUNCTION: Cyclin-dependent protein kinase that acts as a regulator of transcription and pre-mRNA splicing (PubMed:12501247, PubMed:18216018, PubMed:32367068, PubMed:36104565). Acts as a key regulator of pre-mRNA splicing by mediating phosphorylation of SF3B1, enabling the association between SF3B1 and U5 and U6 snRNAs in the activated spliceosome, thereby promoting spliceosome assembly (PubMed:36104565, PubMed:38059508). Also acts as a regulator of transcription by phosphorylating 'Ser-2' of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (PubMed:32367068, PubMed:40858114). Involved in replication-dependent transcription of histone genes: binds to histone genes and phosphorylates POLR2A at 'Ser-2' of the CTD to specifically control transcriptional elongation of histones and recruitment of 3'-end processing factors (PubMed:32367068). Part of a transcription checkpoint upstream of CDK9, which regulates promoter-proximal pausing by RNA polymerase II, a transcription halt following transcription initiation, but prior to elongation (PubMed:40858114). Probably regulates promoter-proximal pausing by mediating phosphorylation of POLR2A at 'Ser-2' of the CTD (PubMed:40858114). Activated by the CDK-activating kinase (CAK) complex consisting of CDK7, cyclin-H/CCNH and MAT1, which is a master regulator of CDK activity (PubMed:41100585). {ECO:0000269|PubMed:12501247, ECO:0000269|PubMed:18216018, ECO:0000269|PubMed:32367068, ECO:0000269|PubMed:36104565, ECO:0000269|PubMed:38059508, ECO:0000269|PubMed:40858114, ECO:0000269|PubMed:41100585}.; FUNCTION: [Isoform SV9]: Isoform expressed in a non-cell cycle-dependent manner. {ECO:0000269|PubMed:12624090}.; FUNCTION: [Isoform 7]: Isoform specifically expressed during the G2-M phases of the cell cycle (PubMed:12082095, PubMed:2217177). Phosphorylates 'Ser-2' of the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A (PubMed:38019613). Promotes centromeric transcription to maintain centromeric cohesion during mitosis (PubMed:24436071, PubMed:38019613). {ECO:0000269|PubMed:12082095, ECO:0000269|PubMed:2217177, ECO:0000269|PubMed:24436071, ECO:0000269|PubMed:38019613}.
uniprot
proteins
mass_dalton
92620
uniprot
proteins
mutagenesis
MUTAGEN 445; /note="E->G: Does not affect binding to anticancer agent OTS964."; /evidence="ECO:0000269|PubMed:36327972"; MUTAGEN 516; /note="M->F: Decreased binding to anticancer agent OTS964."; /evidence="ECO:0000269|PubMed:36327972"; MUTAGEN 579; /note="G->A: Enhanced binding to anticancer agent OTS964."; /evidence="ECO:0000269|PubMed:36327972"; MUTAGEN 579; /note="G->S: Induces resistance to inhibition by anticancer agent OTS964."; /evidence="ECO:0000269|PubMed:31511426, ECO:0000269|PubMed:36104565, ECO:0000269|PubMed:36327972
uniprot
proteins
post_translational_modification
PTM: [Isoform SV9]: During FAS- or TNF-induced apoptosis, isoform SV9 is cleaved by caspases to produce p110C, a fragment that contains the C-terminal kinase domain. {ECO:0000269|PubMed:12624090}.; PTM: Phosphorylation at Ser-115 creates a binding site for 14-3-3 proteins. p110C can be autophosphorylated. {ECO:0000269|PubMed:15883043, ECO:0000269|PubMed:16327805}.
uniprot
proteins
protein_family
CDC2/CDKX subfamily
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10882096
uniprot
proteins
pubmed
11980906
uniprot
proteins
pubmed
12082095
uniprot
proteins
pubmed
12501247
uniprot
proteins
pubmed
12624090
uniprot
proteins
pubmed
14511641
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15883043
uniprot
proteins
pubmed
16327805
uniprot
proteins
pubmed
1639388
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18216018
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
2006197
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
2217177
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24436071
uniprot
proteins
pubmed
25965346
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
31511426
uniprot
proteins
pubmed
32367068
uniprot
proteins
pubmed
34696162
uniprot
proteins
pubmed
36104565
uniprot
proteins
pubmed
36327972
uniprot
proteins
pubmed
38019613
uniprot
proteins
pubmed
38059508
uniprot
proteins
pubmed
40858114
uniprot
proteins
pubmed
41100585
uniprot
proteins
pubmed
8195233
uniprot
proteins
pubmed
9580558
uniprot
proteins
pubmed
9750192
uniprot
proteins
sequence_length
795
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8195233, ECO:0000269|PubMed:9580558}. Chromosome {ECO:0000269|PubMed:40858114}. Cytoplasm {ECO:0000269|PubMed:8195233}. Note=Localizes to transcription start site (TSS) proximal regions. {ECO:0000269|PubMed:32367068, ECO:0000269|PubMed:40858114}.; SUBCELLULAR LOCATION: [Isoform SV9]: Nucleus {ECO:0000269|PubMed:12501247}.; SUBCELLULAR LOCATION: [Isoform 7]: Nucleus {ECO:0000269|PubMed:16710414}. Chromosome, centromere {ECO:0000269|PubMed:24436071, ECO:0000269|PubMed:38019613}.
uniprot
proteins