CYLC1
entrez
1538
canonical
uniprot
P35663
canonical
ensembl
ENSG00000183035
resolver
ensp
ENSP00000331556
resolver
ensp
ENSP00000480907
resolver
enst
ENST00000329312
resolver
enst
ENST00000621735
resolver
genesymbol
CYLC1
resolver
genesymbol_syn
CYL
resolver
genesymbol_syn
CYL1
resolver
hgnc
HGNC:2582
resolver
uniprot
A0A087WXC8
resolver
uniprot
A0AVQ8
resolver
uniprot
Q5JQQ9
resolver
uniprot
Q6PEK4
resolver
uniprot_entry
A0A087WXC8_HUMAN
resolver
uniprot_entry
CYLC1_HUMAN
resolver
uniprot_entry
Q6PEK4_HUMAN
resolver
uniprot_sec
A0AVQ8
resolver
uniprot_sec
Q5JQQ9
resolver
amino_acid_sequence
MSLPRLLKVNIRTYDNSIPISESSRKSWNQKHFALTFPKPLQRGTNDKSRPLKSQITVTRHDKRKLEEGQKPAHKWIRHSFRKILQWPPIYTAAREQTPFRHLYTSKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEKASTGRVPPSREKPPLPACEPSLPSPKVRRLCWCKMPPPPPKPRYAPLPEAPWIHKLL
uniprot
proteins
disease_involvement
DISEASE: Spermatogenic failure, X-linked, 8 (SPGFX8) [MIM:301119]: A male infertility disorder characterized by a significant reduction in progressive sperm motility, and aberrant sperm morphology. Patient sperm show head and midpiece defects with deformed and detached acrosomes, and flagellar defects. {ECO:0000269|PubMed:38013430, ECO:0000269|PubMed:38573307}. Note=Disease susceptibility may be associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Plays a role in the establishment of normal sperm morphology during spermatogenesis and is required for acrosome attachment to the nuclear envelope. {ECO:0000269|PubMed:38573307}.
uniprot
proteins
mass_dalton
74242
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
38013430
uniprot
proteins
pubmed
38573307
uniprot
proteins
pubmed
8354692
uniprot
proteins
sequence_length
651
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, perinuclear theca, calyx {ECO:0000269|PubMed:38013430, ECO:0000269|PubMed:38573307, ECO:0000269|PubMed:8354692}. Cytoplasm, cytoskeleton, perinuclear theca {ECO:0000250|UniProtKB:A0A1B0GR13}. Note=Localizes to the subacrosomal layer of the perinuclear theca in round and elongating spermatids. Localizes to the calyx, also known as post-acrosomal region, in spermatozoa. {ECO:0000250|UniProtKB:A0A1B0GR13}.
uniprot
proteins