Ilk
entrez
170922
canonical
uniprot
Q99J82
canonical
ensembl
ENSRNOG00000018993
resolver
ensembl
ENSRNOG00055024435
resolver
ensembl
ENSRNOG00060019426
resolver
ensembl
ENSRNOG00065032050
resolver
ensp
ENSRNOP00000025906
resolver
ensp
ENSRNOP00000090768
resolver
ensp
ENSRNOP00055034247
resolver
ensp
ENSRNOP00060027544
resolver
ensp
ENSRNOP00065045413
resolver
enst
ENSRNOT00055042011
resolver
enst
ENSRNOT00060033652
resolver
enst
ENSRNOT00065055222
resolver
genesymbol
Ilk
resolver
genesymbol_syn
ILK1
resolver
genesymbol_syn
ILK2
resolver
uniprot_entry
ILK_RAT
resolver
amino_acid_sequence
MDDIFTQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKAPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPRNGTLNKHSGIDFKQLNFLAKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQAPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAPAWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMKICMNEDPAKRPKFDMIVPILEKMQDK
uniprot
proteins
function
FUNCTION: Scaffold protein which mediates protein-protein interactions during a range of cellular events including focal adhesion assembly, cell adhesion and cell migration (By similarity). Regulates integrin-mediated signal transduction by contributing to inside-out integrin activation (PubMed:19299337). Recruits PARVA and LIMS1/PITCH to form the heterotrimeric IPP (ILK-PINCH-PARVIN) complex which binds to F-actin via the C-terminal tail of LIMS1 and the N-terminal region of PARVA, promoting F-actin filament bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration (By similarity). Binding to PARVA promotes effective assembly of ILK into focal adhesions while PARVA-bound ILK can simultaneously engage integrin-beta cytoplasmic tails to mediate cell adhesion (By similarity). Plays a role with PARVG in promoting the cell adhesion and spreading of leukocytes. Acts as an upstream effector of both AKT1/PKB and GSK3 (By similarity). Mediates trafficking of caveolae to the cell surface in an ITGB1-dependent manner by promoting the recruitment of IQGAP1 to the cell cortex which cooperates with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (By similarity). Required for the maintenance of mitotic spindle integrity by promoting phosphorylation of TACC3 by AURKA (By similarity). Associates with chromatin and may act as a negative regulator of transcription when located in the nucleus (By similarity). {ECO:0000250|UniProtKB:O55222, ECO:0000250|UniProtKB:Q13418, ECO:0000269|PubMed:19299337}.
uniprot
proteins
mass_dalton
51373
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by PAK1 modulates ILK subcellular location by promoting its nuclear export. {ECO:0000250|UniProtKB:Q13418}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
TKL Ser/Thr protein kinase family
uniprot
proteins
pubmed
11304546
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19299337
uniprot
proteins
sequence_length
452
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q13418}. Cell membrane {ECO:0000250|UniProtKB:Q13418}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q13418}; Cytoplasmic side {ECO:0000250|UniProtKB:Q13418}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:O55222}. Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:Q13418}. Cytoplasm {ECO:0000250|UniProtKB:Q13418}. Nucleus {ECO:0000250|UniProtKB:Q13418}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q13418}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q13418}.
uniprot
proteins