Fktn
entrez
246179
canonical
uniprot
Q8R507
canonical
ensembl
ENSMUSG00000028414
resolver
ensp
ENSMUSP00000061489
resolver
ensp
ENSMUSP00000114699
resolver
ensp
ENSMUSP00000152867
resolver
ensp
ENSMUSP00000322116
resolver
ensp
ENSMUSP00000327751
resolver
enst
ENSMUST00000061771
resolver
enst
ENSMUST00000128667
resolver
enst
ENSMUST00000221657
resolver
genesymbol
Fktn
resolver
genesymbol_syn
Fcmd
resolver
uniprot
A0A1Y7VM91
resolver
uniprot
Q3UMQ5
resolver
uniprot
Q8VD64
resolver
uniprot_entry
A0A1Y7VM91_MOUSE
resolver
uniprot_entry
FKTN_MOUSE
resolver
uniprot_entry
Q3UMQ5_MOUSE
resolver
uniprot_sec
Q8VD64
resolver
amino_acid_sequence
MSRINKNVVLALLTLTSSAFLLFQLYYYKHYLSARNGPGSSKSKGNRVGFDSTQWRAVKKFIMLTSSQNVPVFLIDPWILESINKNFEQVKNASQGPASECRFFCVPRDFTAFALQYHLWKNEDGWFRIAENMGFQCLKTESKDPRLDGIDSLSGTEIPLHYVCKLTTHAIHLVVFHERSGNYLWHGHLRLKGHMDRKFVPFRKLQFGRYPGAFDRPELQQVTVDGLDMLIPKDPGRFLEEVPHSRFIECRYKEARAFLQQYIDDNTVDAMVFRKRAKELLQLAAKTLKDLGVPFWLSSGTCLGWYRQCGIIPYSKDVDLGIFIQDYKPDIILAFQEAGLPLKHKFGKVEDSLELSFQGKNDVKLDIFFFYEEADHLWNGGTQARTGKKFKYLFPKFTLCWTEFVDIKVHVPCETVDYIEANYGKTWKIPIKTWDWKSSPPNVQPNGIWPISEWDEVIQLY
uniprot
proteins
ec_number
2.7.8.-
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of CDP-ribitol to the distal N-acetylgalactosamine of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1) (PubMed:12471058). This constitutes the first step in the formation of the ribitol 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta-1 (By similarity). Required for normal location of POMGNT1 in Golgi membranes, and for normal POMGNT1 activity (PubMed:19017726). May interact with and reinforce a large complex encompassing the outside and inside of muscle membranes (PubMed:19017726, PubMed:22922256). Could be involved in brain development (Probable). {ECO:0000250|UniProtKB:O75072, ECO:0000269|PubMed:12471058, ECO:0000269|PubMed:19017726, ECO:0000269|PubMed:22922256, ECO:0000305|PubMed:12670716}.
uniprot
proteins
mass_dalton
53579
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:19017726}.
uniprot
proteins
protein_family
LicD transferase family
uniprot
proteins
pubmed
12408965
uniprot
proteins
pubmed
12471058
uniprot
proteins
pubmed
12670716
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19017726
uniprot
proteins
pubmed
22922256
uniprot
proteins
pubmed
29416295
uniprot
proteins
sequence_length
461
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:12471058}; Single-pass type II membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:29416295}. Nucleus {ECO:0000269|PubMed:29416295}. Endoplasmic reticulum {ECO:0000305|PubMed:29416295}. Note=In retinal tissue, does not localize with the Golgi apparatus. {ECO:0000269|PubMed:29416295}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins