Kcnj2
entrez
16518
canonical
uniprot
P35561
canonical
ensembl
ENSMUSG00000041695
resolver
ensp
ENSMUSP00000037192
resolver
enst
ENSMUST00000042970
resolver
genesymbol
Kcnj2
resolver
genesymbol_syn
Irk1
resolver
uniprot
Q543W5
resolver
uniprot_entry
KCNJ2_MOUSE
resolver
uniprot_entry
Q543W5_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphatidylinositol 4,5 biphosphate (PtdIns(4,5)P2). {ECO:0000250|UniProtKB:Q64273}.
uniprot
proteins
amino_acid_sequence
MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDTSKVSKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHYYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEEEDSENGVPESTSTDSPPGIDLHNQASVPLEPRPLRRESEI
uniprot
proteins
function
FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (PubMed:7680768, PubMed:8282096). Can be blocked by extracellular barium and cesium. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues (By similarity). {ECO:0000250|UniProtKB:P63252, ECO:0000269|PubMed:7680768, ECO:0000269|PubMed:8282096}.
uniprot
proteins
mass_dalton
48389
uniprot
proteins
post_translational_modification
PTM: S-nitrosylation increases the open probability and inward rectifying currents. {ECO:0000250|UniProtKB:P63252}.
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ2 subfamily
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21209095
uniprot
proteins
pubmed
7680768
uniprot
proteins
pubmed
8282096
uniprot
proteins
pubmed
9533862
uniprot
proteins
sequence_length
428
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21209095}; Multi-pass membrane protein {ECO:0000255}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:Q64273}.
uniprot
proteins
transmembrane_region
TRANSMEM 82..106; /note="Helical; Name=M1"; /evidence="ECO:0000250"; TRANSMEM 157..178; /note="Helical; Name=M2"; /evidence="ECO:0000250
uniprot
proteins