C0HLU6
uniprot
C0HLU6
canonical
amino_acid_sequence
MAKRGFNCLLLSISEIDLPVKRLESPNKTRRPYGASIY
uniprot
proteins
function
FUNCTION: Plays a role as a neuroprotective factor (PubMed:12154011). Protects against neuronal cell death induced by amyloid-beta peptides (PubMed:12154011). Also protects against excitotoxic cell death (PubMed:12154011). Prevents amyloid-beta peptide-induced spatial learning and memory impairments, protects against amyloid-beta peptide-induced suppression of hippocampal long-term potentiation, and inhibits amyloid-beta peptide-induced activation of STAT3 and inhibition of CASP3 (PubMed:23996574). Prevents glutamate-induced dendritic atrophy in hippocampal neurons and also prevents glutamate-induced decrease in SYP puncta number and total puncta area (PubMed:31214013). Protects anterior pituitary cells from TNF-induced apoptosis (PubMed:25360890). Plays a role in ovarian follicle development by acting as a cryoprotective factor for granulosa cells in the antral follicle (PubMed:33764899). Increases androgen production in Leydig cells and promotes Leydig cell survival by preventing apoptosis (PubMed:16619233). {ECO:0000269|PubMed:12154011, ECO:0000269|PubMed:16619233, ECO:0000269|PubMed:23996574, ECO:0000269|PubMed:25360890, ECO:0000269|PubMed:31214013, ECO:0000269|PubMed:33764899}.
uniprot
proteins
mass_dalton
4338
uniprot
proteins
pubmed
12154011
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
16619233
uniprot
proteins
pubmed
19623253
uniprot
proteins
pubmed
23996574
uniprot
proteins
pubmed
25360890
uniprot
proteins
pubmed
26116236
uniprot
proteins
pubmed
31214013
uniprot
proteins
pubmed
33764899
uniprot
proteins
sequence_length
38
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:26116236}. Secreted {ECO:0000269|PubMed:16619233, ECO:0000269|PubMed:31214013}. Cytoplasm {ECO:0000269|PubMed:25360890}. Note=Detected in the cytoplasm of anterior pituitary cells. {ECO:0000269|PubMed:25360890}.
uniprot
proteins