Eif2b5
entrez
192234
canonical
uniprot
Q64350
canonical
ensembl
ENSRNOG00000038160
resolver
ensembl
ENSRNOG00055004929
resolver
ensembl
ENSRNOG00060012025
resolver
ensembl
ENSRNOG00065004327
resolver
ensp
ENSRNOP00000002321
resolver
ensp
ENSRNOP00055005919
resolver
ensp
ENSRNOP00060016043
resolver
ensp
ENSRNOP00065004468
resolver
enst
ENSRNOT00000002321
resolver
enst
ENSRNOT00055007862
resolver
enst
ENSRNOT00060020385
resolver
enst
ENSRNOT00065006306
resolver
genesymbol
Eif2b5
resolver
genesymbol_syn
Eif2be
resolver
uniprot
Q5RKL3
resolver
uniprot_entry
EI2BE_RAT
resolver
uniprot_sec
Q5RKL3
resolver
activity_regulation
ACTIVITY REGULATION: Activated by the chemical integrated stress response (ISR) inhibitor ISRIB which stimulates guanine nucleotide exchange factor activity for both phosphorylated and unphosphorylated eIF2. {ECO:0000250|UniProtKB:Q13144}.
uniprot
proteins
amino_acid_sequence
MAATAAVPSAVGGRANKRGGGSGGGGTQGAEEEPPPPLQAVLVADSFDRRFFPISKDQPRVLLPLANVALIDYTLEFLTATGVQETFVFCCWKAAQIKEHLQKSKWCHPTSLNVVRIITSDLYRSLGDVLRDVDAKALVRSDFLLIYGDVVSNINISKALEEHRLRRKLEKNVSVMTMVFKESSPSHPTRCHEDNVVLAVDSTTNRILHFQKTQGLRHFSFPLGLFQGSLDGVEIRYDLLDCHISICSPQVAQLFTDNFDYQTRDDFVRGLLVNEEILGNQIHLHVTSREYGARVSNLHMYSAVCADVIRRWVYPLTPEVNFTDSSTQSYTHSRHNIYRGPEVSLGHGSVLEENVLLGAGTVVGSNCSITNSVIGPNCHIGDNVVLDQAYLWQGVRVAAGAQIHQSLLCDRAEVKERVILKPHCVLTSQVVVGPDIILPEGSVISLHPPDAEEDEDDGQFSDDSGADQEKEKVKLKGYNPAEVGPEGQGYLWKAEDVDEKEDEELRQSLWGLMINMEEESETESERSVDPEELDSRAGSPQLDDIRVFQNEVLGTLQRGREENISCDNLVLEINSLKYAYNISLKEVMQVLSHVVLEFPLQQVDGVLDPNRYCALLLPLLKAWSPVFRNYIKRAADHLEALAAIEDFFLEHETLVPSLAKVLMAFYQLEILAEETILSWFSQRDITDKGQQLRKNQQLQRFIQWLREAEEESSDDD
uniprot
proteins
function
FUNCTION: Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed. {ECO:0000250|UniProtKB:Q13144}.
uniprot
proteins
mass_dalton
80206
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine and threonine residues by GSK3B; phosphorylation inhibits its function (By similarity). Phosphorylated at Ser-539 by DYRK2; this is required for subsequent phosphorylation by GSK3B. {ECO:0000250, ECO:0000269|PubMed:11311121, ECO:0000269|PubMed:23707720}.; PTM: Polyubiquitinated, probably by NEDD4. {ECO:0000269|PubMed:23707720}.
uniprot
proteins
protein_family
EIF-2B gamma/epsilon subunits family
uniprot
proteins
pubmed
11311121
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23707720
uniprot
proteins
pubmed
8688467
uniprot
proteins
sequence_length
716
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P56287}.
uniprot
proteins