Shkbp1
entrez
292735
canonical
uniprot
P0C5J9
canonical
ensembl
ENSRNOG00000020882
resolver
ensp
ENSRNOP00000028348
resolver
enst
ENSRNOT00000028348
resolver
genesymbol
Shkbp1
resolver
genesymbol_syn
Sb1
resolver
uniprot_entry
SHKB1_RAT
resolver
amino_acid_sequence
MAVPTTAVEGVRSRGAPGEVIHLNVGGKRFSTSRQTLTWIPDSFFSSLLSGRISTLKDETGAIFIDRDPTVFAPILNFLRTKELDPRGVHGSSLLHEAQFYGLTPLVRRLQVREELDRSSCGNVLFNGYLPPPVFPVKRRNRHSLVGPQQIGGRPAPVRRSNTMPPNLGNAGLLGRMLDDRAPPSPSGQPEEPGMVRLVCGHHNWIAVAYTHFLVCYRLKEASGWQLAFSSPRLDWPIERLALTARVLGGAPGEHDKMVAAATGSEILLWALQAQGGGSEIGVFHLGVPVEALFFVGNQLIATSHTGRIGVWNAVTKHWQVQEVQPITSYDAAGSFLLLGCSNGSIYYVDVQKFPLRMKDNDLLVSELYRDPAEDGVTALSVYLTPKTSDSGNWIEIAYGTSSGVVRVIVQHPETVGSGPQLFQTFSVHRSPVTKIMLSEKHLISVCADNNHVRTWSVTRFRGMISTQPGSTPLASFKILALESADGLGGCSAGNDIGPYGERDDQQVFIQKVVPNASQLFVRLSSTGQRVCSVRSVDGSATTAFTVLECEGSRRLGSRPRRYLLTGQANGSLAMWDLTTAMDGLGQTPAGGLTEEELMDQLEQCELSPLTSSRASFPSPSPRTSLTSLHSASSNTSLCGHRGSPSPPQAGARSRGAGSFVDRFKELARGAPELRGPPTPAPRPSTSLGNPLILPKNTLNETSF
uniprot
proteins
function
FUNCTION: Inhibits CBL-SH3KBP1 complex mediated down-regulation of EGFR signaling by sequestration of SH3KBP1. Binds to SH3KBP1 and prevents its interaction with CBL and inhibits translocation of SH3KBP1 to EGFR containing vesicles upon EGF stimulation. {ECO:0000250|UniProtKB:Q6P7W2}.
uniprot
proteins
mass_dalton
75972
uniprot
proteins
protein_family
KCTD3 family
uniprot
proteins
pubmed
11152963
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
704
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:Q8TBC3}.
uniprot
proteins