OPRD1
entrez
4985
canonical
uniprot
P41143
canonical
ensembl
ENSG00000116329
resolver
ensp
ENSP00000234961
resolver
enst
ENST00000234961
resolver
genesymbol
OPRD1
resolver
genesymbol_syn
OPRD
resolver
hgnc
HGNC:8153
resolver
uniprot
B5B0B8
resolver
uniprot_entry
OPRD_HUMAN
resolver
uniprot_sec
B5B0B8
resolver
amino_acid_sequence
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that functions as a receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. Plays a role in developing analgesic tolerance to morphine. {ECO:0000269|PubMed:22184124, ECO:0000269|PubMed:7808419, ECO:0000269|PubMed:8201839}.
uniprot
proteins
mass_dalton
40369
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:22184124}.; PTM: Ubiquitinated. A basal ubiquitination does not seem to be related to degradation. Ubiquitination is increased upon formation of OPRM1:OPRD1 oligomers leading to proteasomal degradation; the ubiquitination is diminished by RTP4. {ECO:0000250|UniProtKB:P32300}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10982041
uniprot
proteins
pubmed
12142540
uniprot
proteins
pubmed
12847517
uniprot
proteins
pubmed
15086532
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
22184124
uniprot
proteins
pubmed
22417668
uniprot
proteins
pubmed
7808419
uniprot
proteins
pubmed
8201839
uniprot
proteins
sequence_length
372
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22184124, ECO:0000269|PubMed:7808419, ECO:0000269|PubMed:8201839}; Multi-pass membrane protein {ECO:0000269|PubMed:22184124, ECO:0000269|PubMed:7808419, ECO:0000269|PubMed:8201839}.
uniprot
proteins
transmembrane_region
TRANSMEM 48..75; /note="Helical; Name=1"; /evidence="ECO:0000250"; TRANSMEM 86..110; /note="Helical; Name=2"; /evidence="ECO:0000250"; TRANSMEM 123..144; /note="Helical; Name=3"; /evidence="ECO:0000250"; TRANSMEM 164..186; /note="Helical; Name=4"; /evidence="ECO:0000250"; TRANSMEM 207..238; /note="Helical; Name=5"; /evidence="ECO:0000250"; TRANSMEM 262..284; /note="Helical; Name=6"; /evidence="ECO:0000250"; TRANSMEM 300..321; /note="Helical; Name=7"; /evidence="ECO:0000250
uniprot
proteins