Slc4a4
entrez
54403
canonical
uniprot
O88343
canonical
ensembl
ENSMUSG00000060961
resolver
ensp
ENSMUSP00000108844
resolver
ensp
ENSMUSP00000118413
resolver
ensp
ENSMUSP00000119325
resolver
ensp
ENSMUSP00000121744
resolver
ensp
ENSMUSP00000159229
resolver
ensp
ENSMUSP00000291162
resolver
ensp
ENSMUSP00000291163
resolver
ensp
ENSMUSP00000291164
resolver
enst
ENSMUST00000113218
resolver
enst
ENSMUST00000156238
resolver
enst
ENSMUST00000239214
resolver
genesymbol
Slc4a4
resolver
genesymbol_syn
Nbc1
resolver
genesymbol_syn
Nbce1
resolver
genesymbol_syn
slc4a4
resolver
uniprot
A0A668KM61
resolver
uniprot
A2VDF7
resolver
uniprot
A7E1Z5
resolver
uniprot
E1AWU4
resolver
uniprot
E3VWA1
resolver
uniprot
E9Q8N8
resolver
uniprot
F8WJH4
resolver
uniprot
Q3USE4
resolver
uniprot
Q8BUG0
resolver
uniprot
Q8QZR9
resolver
uniprot
Q9R1C4
resolver
uniprot_entry
A0A668KM61_MOUSE
resolver
uniprot_entry
A2VDF7_MOUSE
resolver
uniprot_entry
A7E1Z5_MOUSE
resolver
uniprot_entry
E1AWU4_MOUSE
resolver
uniprot_entry
E3VWA1_MOUSE
resolver
uniprot_entry
E9Q8N8_MOUSE
resolver
uniprot_entry
F8WJH4_MOUSE
resolver
uniprot_entry
S4A4_MOUSE
resolver
uniprot_sec
Q3USE4
resolver
uniprot_sec
Q8BUG0
resolver
uniprot_sec
Q8QZR9
resolver
uniprot_sec
Q9R1C4
resolver
activity_regulation
ACTIVITY REGULATION: Activated by cyclic AMP. {ECO:0000269|PubMed:12388213}.
uniprot
proteins
amino_acid_sequence
MEDEAVLDRGASFLKHVCDEEEVEGHHTIYIGVHVPKSYRRRRRHKRKAGHKEKKEKERISENYSDKSDVENADESSSSILKPLISPAAERIRFILGEEDDSPAPPQLFTELDELLAVDGQEMEWKETARWIKFEEKVEQGGERWSKPHVATLSLHSLFELRTCMEKGSIMLDREASSLPQLVEMIADHQIETGLLKPDLKDKVTYTLLRKHRHQTKKSNLRSLADIGKTVSSASRMFSNPDNGSPAMTHRNLTSSSLNDISDKPEKDQLKNKFMKKLPRDAEASNVLVGEVDFLDTPFIAFVRLQQAVMLGALTEVPVPTRFLFILLGPKGKAKSYHEIGRAIATLMSDEVFHDIAYKAKDRHDLIAGIDEFLDEVIVLPPGEWDPTIRIEPPKSLPSSDKRKNMYSGGENVQMNGDTPHDGGHGGGGHGDCEELQRTGRFCGGLIKDIKRKAPFFASDFYDALNIQALSAILFIYLATVTNAITFGGLLGDATDNMQGVLESFLGTAVSGAIFCLFAGQPLTILSSTGPVLVFERLLFNFSKDHNFDYLEFRLWIGLWSAFMCLVLVATDASFLVQYFTRFTEEGFSSLISFIFIYDAFKKMIKLADYYPINSDFKVGYNTHFSCACLPPDPVNLSVSNDTTLAPEDLPTISSTDMYHNVTFDWAYLSKKECVKYGGKLVGNNCDFVPDITLMSFILFLGTYTSSMAMKKFKTSRYFPTTARKLISDFAIILSILIFCVIDALVGVDTPKLIVPSEFKPTSPNRGWFVPPFGGNPWWVCLAAAIPALLVTILIFMDQQITAVIVNRKEHKLKKGAGYHLDLFWVAILMVVCSFMALPWYVAATVISIAHIDSLKMETETSAPGEQPKFLGVREQRVTGTLVFILTGLSVFMAPILKFIPMPVLYGVFLYMGVASLNGVQFMDRLKLLLMPLKHQPDFIYLRHVPLRRVHLFTFLQVLCLALLWILKSTVAAIIFPVMILALVAVRKGMDYLFSQHDLSFLDDVIPEKDKKKKEDEKKKKKKKGSLDSDNDDSDCPYSEKVPSIKIPMDIMEQQPFLSDNKPLDRERSSTFLERHTSC
uniprot
proteins
function
FUNCTION: Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. {ECO:0000269|PubMed:11171615, ECO:0000269|PubMed:12388213, ECO:0000269|PubMed:19033647, ECO:0000269|PubMed:9651366}.
uniprot
proteins
mass_dalton
121484
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Ser-1026 by PKA increases the binding of CA2 and changes the Na(+):HCO3(-) stoichiometry of the transporter from 3:1 to 2:1. Phosphorylated in presence of STK39 and dephosphorylated in presence of PP1 phosphatase; phosphorylation seems to inhibit SLC4A4 activity (PubMed:21317537). {ECO:0000250|UniProtKB:Q9Y6R1, ECO:0000269|PubMed:21317537}.; PTM: N-glycosylated. May not be necessary for the transporter basic functions. {ECO:0000269|PubMed:12604466}.
uniprot
proteins
protein_family
Anion exchanger (TC 2.A.31) family
uniprot
proteins
pubmed
11171615
uniprot
proteins
pubmed
12388213
uniprot
proteins
pubmed
12604466
uniprot
proteins
pubmed
12727194
uniprot
proteins
pubmed
14567693
uniprot
proteins
pubmed
15218065
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16769890
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
19033647
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21317537
uniprot
proteins
pubmed
27382360
uniprot
proteins
pubmed
9651366
uniprot
proteins
sequence_length
1079
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:11171615}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:21317537}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 467..491; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q9Y6R1"; TRANSMEM 502..520; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q9Y6R1"; TRANSMEM 522..542; /note="Discontinuously helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q9Y6R1"; TRANSMEM 551..571; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q9Y6R1"; TRANSMEM 586..609; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q9Y6R1"; TRANSMEM 693..710; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q9Y6R1"; TRANSMEM 726..745; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q9Y6R1"; TRANSMEM 780..807; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q9Y6R1"; TRANSMEM 820..836; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q9Y6R1"; TRANSMEM 838..855; /note="Discontinuously helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q9Y6R1"; TRANSMEM 878..894; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q9Y6R1"; TRANSMEM 902..918; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:Q9Y6R1
uniprot
proteins