Prnp
entrez
24686
canonical
uniprot
P13852
canonical
ensembl
ENSRNOG00000021259
resolver
ensembl
ENSRNOG00055005843
resolver
ensembl
ENSRNOG00060002012
resolver
ensembl
ENSRNOG00065013804
resolver
ensp
ENSRNOP00000028881
resolver
ensp
ENSRNOP00000081843
resolver
ensp
ENSRNOP00000085462
resolver
ensp
ENSRNOP00000089546
resolver
ensp
ENSRNOP00000093957
resolver
ensp
ENSRNOP00000096232
resolver
ensp
ENSRNOP00055007259
resolver
ensp
ENSRNOP00055007261
resolver
ensp
ENSRNOP00055007263
resolver
ensp
ENSRNOP00060002135
resolver
ensp
ENSRNOP00060002136
resolver
ensp
ENSRNOP00060002140
resolver
ensp
ENSRNOP00065017592
resolver
ensp
ENSRNOP00065017594
resolver
ensp
ENSRNOP00065017600
resolver
enst
ENSRNOT00000028881
resolver
enst
ENSRNOT00000094429
resolver
enst
ENSRNOT00000098238
resolver
enst
ENSRNOT00000106614
resolver
enst
ENSRNOT00000113525
resolver
enst
ENSRNOT00000117610
resolver
enst
ENSRNOT00055009443
resolver
enst
ENSRNOT00055009445
resolver
enst
ENSRNOT00055009447
resolver
enst
ENSRNOT00060003151
resolver
enst
ENSRNOT00060003152
resolver
enst
ENSRNOT00060003157
resolver
enst
ENSRNOT00065022695
resolver
enst
ENSRNOT00065022697
resolver
enst
ENSRNOT00065022703
resolver
genesymbol
Prnp
resolver
genesymbol_syn
Prn
resolver
genesymbol_syn
Prp
resolver
uniprot
Q549H6
resolver
uniprot_entry
PRIO_RAT
resolver
uniprot_sec
Q549H6
resolver
amino_acid_sequence
MANLGYWLLALFVTTCTDVGLCKKRPKPGGWNTGGSRYPGQGSPGGNRYPPQSGGTWGQPHGGGWGQPHGGGWGQPHGGGWGQPHGGGWSQGGGTHNQWNKPSKPKTNLKHVAGAAAAGAVVGGLGGYMLGSAMSRPMLHFGNDWEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCVTQYQKESQAYYDGRRSSAVLFSSPPVILLISFLIFLIVG
uniprot
proteins
disease_involvement
DISEASE: Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc. {ECO:0000305}.
uniprot
proteins
function
FUNCTION: Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or Zn(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity). {ECO:0000250|UniProtKB:P04156, ECO:0000250|UniProtKB:P04925}.
uniprot
proteins
mass_dalton
27804
uniprot
proteins
protein_family
Prion family
uniprot
proteins
pubmed
10373359
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2889848
uniprot
proteins
pubmed
7909925
uniprot
proteins
pubmed
8879116
uniprot
proteins
sequence_length
254
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P04156}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P04156}. Golgi apparatus {ECO:0000250|UniProtKB:P04925}. Note=Targeted to lipid rafts via association with the heparan sulfate chains of GPC1. Colocates, in the presence of Cu(2+), to vesicles in para- and perinuclear regions, where both proteins undergo internalization. Heparin displaces PRNP from lipid rafts and promotes endocytosis. {ECO:0000250|UniProtKB:P04156}.
uniprot
proteins