Camk2n1
entrez
287005
canonical
uniprot
Q9JI15
canonical
ensembl
ENSRNOG00060006453
resolver
ensp
ENSRNOP00060007838
resolver
enst
ENSRNOT00060010577
resolver
genesymbol
Camk2n1
resolver
uniprot_entry
CK2N1_RAT
resolver
amino_acid_sequence
MSEVLPYGDEKLSPYGDGGDVGQIFSCRLQDTNNFFGAGQSKRPPKLGQIGRSKRVVIEDDRIDDVLKTMTDKAPPGV
uniprot
proteins
function
FUNCTION: Potent and specific inhibitor of CaM-kinase II (CAMK2) (PubMed:11182241). Plays a role in the maintenance of long-term retrieval-induced memory in response to contextual fear (By similarity). Modulates blood pressure and vascular reactivity via regulation of CAMK2 activity in addition to regulation of left ventricular mass (PubMed:31327268). Mediates the NLRP3 inflammasome in cardiomyocytes via acting as an inhibitor of the MAPK14/p38 and MAPK8/JNK pathways, thereby regulating ventricular remodeling and cardiac rhythm post-myocardial infarction (By similarity). Negatively effects insulin sensitivity and promotes lipid formation in adipose tissues independent of CAMK2 signaling (PubMed:31327268). {ECO:0000250|UniProtKB:Q6QWF9, ECO:0000269|PubMed:11182241, ECO:0000269|PubMed:31327268}.
uniprot
proteins
mass_dalton
8513
uniprot
proteins
mutagenesis
MUTAGEN 43; /note="R->P: Reduces at least 100-fold the inhibitory potency; when associated with 59-K--A-61."; /evidence="ECO:0000269|PubMed:11182241"; MUTAGEN 58; /note="I->S: Slightly phosphorylated."; /evidence="ECO:0000269|PubMed:11182241"; MUTAGEN 59..61; /note="EDD->KLA: Reduces at least 100-fold the inhibitory potency; when associated with P-43."; /evidence="ECO:0000269|PubMed:11182241
uniprot
proteins
protein_family
CAMK2N family
uniprot
proteins
pubmed
11182241
uniprot
proteins
pubmed
31327268
uniprot
proteins
sequence_length
78
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Synapse {ECO:0000250|UniProtKB:Q6QWF9}. Cell projection, dendrite {ECO:0000269|PubMed:11182241}. Postsynaptic density {ECO:0000250|UniProtKB:Q6QWF9}.
uniprot
proteins