Eif4e2
entrez
26987
canonical
uniprot
Q8BMB3
canonical
ensembl
ENSMUSG00000026254
resolver
ensp
ENSMUSP00000053403
resolver
ensp
ENSMUSP00000075699
resolver
ensp
ENSMUSP00000108857
resolver
ensp
ENSMUSP00000108859
resolver
ensp
ENSMUSP00000108861
resolver
ensp
ENSMUSP00000321536
resolver
ensp
ENSMUSP00000321537
resolver
ensp
ENSMUSP00000321540
resolver
ensp
ENSMUSP00000345200
resolver
enst
ENSMUST00000050876
resolver
enst
ENSMUST00000076362
resolver
enst
ENSMUST00000113231
resolver
enst
ENSMUST00000113233
resolver
enst
ENSMUST00000113235
resolver
genesymbol
Eif4e2
resolver
genesymbol_syn
Eif4el3
resolver
uniprot
D3YUV9
resolver
uniprot
D3Z729
resolver
uniprot
F7A1P0
resolver
uniprot
G3X9H1
resolver
uniprot
O88503
resolver
uniprot
Q0P688
resolver
uniprot
Q3UCK2
resolver
uniprot_entry
D3YUV9_MOUSE
resolver
uniprot_entry
D3Z729_MOUSE
resolver
uniprot_entry
F7A1P0_MOUSE
resolver
uniprot_entry
G3X9H1_MOUSE
resolver
uniprot_entry
IF4E2_MOUSE
resolver
uniprot_entry
Q0P688_MOUSE
resolver
uniprot_sec
O88503
resolver
uniprot_sec
Q3UCK2
resolver
amino_acid_sequence
MNNKFDALKDDDSGDHDQNEENSTQKDGEKEKTDRDKSQSSGKRKAVVPGPAEHPLQYNYTFWYSRRTPGRPTSSQSYEQNIKQIGTFASVEQFWKFYSHMVRPGDLTGHSDFHLFKEGIKPMWEDDANKNGGKWIIRLRKGLASRCWENLILAMLGEQFMVGEEICGAVVSVRFQEDIISIWNKTASDQATTARIRDTLRRVLNLPPNTIMEYKTHTDSIKMPGRLGPQRLLFQNLWKPRLNVP
uniprot
proteins
function
FUNCTION: Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:15153109). Acts as a repressor of translation initiation (By similarity). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (PubMed:15153109). In P-bodies, component of a complex that promotes miRNA-mediated translational repression (By similarity). Involved in virus-induced host response by mediating miRNA MIR34A-induced translational silencing which controls IFNB1 production by a negative feedback mechanism (By similarity). {ECO:0000250|UniProtKB:O60573, ECO:0000269|PubMed:15153109}.; FUNCTION: Component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation. In association with GIGYF2, assists ribosome-associated quality control (RQC) by sequestering the mRNA cap, blocking ribosome initiation and decreasing the translational load on problematic messages. Part of a pathway that works in parallel to RQC-mediated degradation of the stalled nascent polypeptide. GIGYF2 and EIF4E2 work downstream and independently of ZNF598, which seems to work as a scaffold that can recruit them to faulty mRNA even if alternative recruitment mechanisms may exist. {ECO:0000250|UniProtKB:O60573}.
uniprot
proteins
mass_dalton
28263
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by ARIH1. The consequences of ubiquitination are however unclear: according to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest. According to another report ubiquitination leads to its subsequent degradation. {ECO:0000250|UniProtKB:O60573}.; PTM: ISGylation enhances its cap structure-binding activity and translation-inhibition activity. {ECO:0000250|UniProtKB:O60573}.
uniprot
proteins
protein_family
Eukaryotic initiation factor 4E family
uniprot
proteins
pubmed
15153109
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22751931
uniprot
proteins
sequence_length
245
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O60573}. Cytoplasm, P-body {ECO:0000250|UniProtKB:O60573}.
uniprot
proteins