Prmt6
entrez
99890
canonical
uniprot
Q6NZB1
canonical
ensembl
ENSMUSG00000049300
resolver
ensp
ENSMUSP00000102177
resolver
ensp
ENSMUSP00000129801
resolver
ensp
ENSMUSP00000140836
resolver
enst
ENSMUST00000106567
resolver
enst
ENSMUST00000168412
resolver
enst
ENSMUST00000190378
resolver
genesymbol
Prmt6
resolver
genesymbol_syn
Hrmt1l6
resolver
uniprot
Q3TA42
resolver
uniprot
Q8BN52
resolver
uniprot
Q8BSC2
resolver
uniprot
Q8R5D7
resolver
uniprot_entry
ANM6_MOUSE
resolver
uniprot_sec
Q3TA42
resolver
uniprot_sec
Q8BN52
resolver
uniprot_sec
Q8BSC2
resolver
uniprot_sec
Q8R5D7
resolver
amino_acid_sequence
MSLSKKRKLESGDSGGAGAGGEGAEEENGGEQEAAPPRPRRTKSERDQLYYECYSDVSVHEEMIADQVRTEAYRLGILKNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRLNGLEDRVHVLPGPVETVELPERVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFVAPISDQMLEWRLGFWSQVKQHYGVDMSCMESFATRCLMGHSEIVVQDLSGEDVLARPQRFAQLELARAGLEQELEAGVGGRFRCSCYGSAPLHGFAVWFQVTFPGGDSEKPLVLSTSPFHPATHWKQALLYLNEPVPVEQDTDISGEITLLPSPDNPRRLRILLRYKVGDHEEKTKDFAMED
uniprot
proteins
ec_number
2.1.1.319
uniprot
proteins
function
FUNCTION: Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA (PubMed:22904064, PubMed:26070566). Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates (By similarity). Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a (By similarity). H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3) (By similarity). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53 (PubMed:22904064). Repression of TP53 blocks cellular senescence (PubMed:22904064). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively) (By similarity). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity (By similarity). Methylates HMGA1 (By similarity). Regulates alternative splicing events (By similarity). Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1 (By similarity). Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator (PubMed:24570487). Methylates GPS2, protecting GPS2 from ubiquitination and degradation (PubMed:26070566). Methylates SIRT7, inhibiting SIRT7 histone deacetylase activity and promoting mitochondria biogenesis (By similarity). {ECO:0000250|UniProtKB:Q96LA8, ECO:0000269|PubMed:22904064, ECO:0000269|PubMed:24570487, ECO:0000269|PubMed:26070566}.
uniprot
proteins
mass_dalton
41866
uniprot
proteins
post_translational_modification
PTM: Automethylation enhances its stability. {ECO:0000250|UniProtKB:Q96LA8}.; PTM: Ubiquitinated by the SCF-FBXO24 E3 ubiquitin ligase, leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q96LA8}.
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
PRMT6 subfamily
uniprot
proteins
protein_family
Protein arginine N-methyltransferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
22904064
uniprot
proteins
pubmed
24570487
uniprot
proteins
pubmed
26070566
uniprot
proteins
sequence_length
378
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96LA8}.
uniprot
proteins