Q8K3K1
uniprot
Q8K3K1
canonical
amino_acid_sequence
MYYLALSSGFLGQAIKTSILAYLASVLLAASQGVFPRLENVGAFKKVSIVPSHATCGYPGPSTFCRSAVAAEHAQLCAERLCIQDCPYRSASPPYTALLEGLRSCIPADHGDLHPYSRSNSTSFIFGSHKNCPSLQAPRLAAEFTLAVWLKPERGSTMCVLEKTADGQIVFKVTISERETMFYYRTVNGLQPPIKVMTPGRILMKKWIHHTVQVHETEVSSFVDGLEENSTAFDTRTLRDSIMDSVPSTVLIGQSLNGSELFVGRMQDFRLYNVSLTNREILELFSGDLPHLHIQSHCRCPGSHPRVHPSVQQYCIPNGVEDTLQHRVSRLNPEAHPLSFINDDDVATSWISHVFTDITQLNQGVAISIDLENGQYQVFQITIRFSSPQPVAMRIQRKKADKSLWEDWQYFARNCSVWGMKNNGDLENPNSVNCLQFPEFIPFSHGNVTFDLLTSGQKHRPGDYDFYNSSLLQEFMTATQIRLYFRGLFYPAWHTVDSRHRYYAVDEITIIGRCQCHGHAETCDRTRRPYRCLCSPHSFTEGPQCGRCSPLYNDKPFRSGNKVHAFNCKPCQCHGHASSCHYDASMDPFPLEYNRGGGGVCDDCQHHTTGRNCESCQDYFYRPIGADPADPEVCKHCDCNRDGTRNGSLLCDLVGDQCDCKRRVSGRRCFRCHIGFYGLQALDPDCCRPCDCNPSGTVDGDITCHHNSGQCSCKANVIGLRCDRCSFGFKFLRSLNADGCEPCHCNLHGSVNQLCDPLSGQCVCKKEAKGLRCDVCRENFYGLPWSACEVCDCNRAGTQAGTVCDAETGQCVCKPSVGGRRCSECKEGYFNLRQNDSHLCLPCNCEKTGTVNGSLLCDKSTGQCPCKLGVTGLRCHQCKPHRFNLTMDNPQGCQACDCDSLGTLLGSMCDPVSGQCLCLPHRQERRCVQCQPGCYSSPSNATGCLPCLCHTVATKNCICNSVTGHCYCPDPSTTGLSWHQCQDRYFRFDPLTGRCRPCHCHVAGASNGTCDAVTGQCFCKEFVTGSKCDTCVPGASHLDVNNLLACSKTPSQQPPPRGRVQSSSAINLSWSPPDFPNAHWLTYTLFRDDSEIYTTDDQHPYYTQYFLDTSLSPHTAYSYYIETSNVHSSTRSIPVIYKTKPEGSEGHLNLTHIIPVASDSITLVWTGLSNHSGPIEKYVLSCTPVDHTEPCVSYEGPETSATIRNLVPFTQYCFSVQGCTNGSCLYSSPITVTTAQAPPQRQEPPTVWKISPTELKVEWSRPVDSNGVIIRYELYMKRWPSTEESLVFESHGWFHSHPASPSANQSENVLQDPQVSTVLSGLDPHTEYAFRVLAVNMAGSVSSAWASERTGESAPVFMAAPSVSPLSPYSLSVSWEKPAENFTRGEIIGYKISMVSERSPQRDVPVMCSKLVHFAESQDQSYIVQRLKPYRTYSFTVSLCASVGCVTSALGEGQTLAAAPAQLRSPMVTGVTSTTVHIRWLPPAEVNGPPPLYRLERRESFLPAATAARTKGTRFMGDGYCRFPRTAHPDFIGIKASFWTRVPEGLILLALHPDNQEEYFALQLKSGRPYFLYNPQGSLVEVTTADDHSQQYSDGQWHEITAIRHQSFGQITLDEQYTDSSASLNGSSVTGGYTRLFVGGLPQGHTILQKRPVRRGFVGCLKDVSILKGSSPSGTWLPLDWQSSEEQVNVHHSWEGCPTDLEEGVQFLGAGFLELRSDTFHAAKDFEISLKFQTDQLNGLLLFIHNTEGLDFLAMELKSGLLSFQLNSSRILTRVEVRLGRTHCDGKWNRVTIRREGSMVSVGVNELTKSTSRAGDQPPLLTSPVYLGGIPQELQASYRHLTLEQGFRGCVKEVAFTRGAVVNLASVSSRAVRVNQDGCLSSDSTVNCGGNDSILVYRGSRQSVYESGLQPFTEYLYRVTASHKGGSVSSDWSRGRTLGSAPHSVPTPSRAQSINGYSVEVAWNEPAMVKGVLEKYILKAYSEDSAQPHMPSASTEFNNTDIRTGILTGLHPFHSYAVTLTACSRAGCTESSRALSISTPQEAPQEVQAPVAEALPNSLSFFWSPPRQANGIITQYSLYMDGRLVYTGKGQNYTVTDLRVFTAYEITVGACTRAGCTNSSRVILHTAQLPPERVDPPVLAILDSRTVHIQWKQPRQLNGILERYILYTLNPTHNSTVWDVVYNSTENLQTHLLYHLSPGCLYLIKLGACTGGGCTTSEPSQALMDETVPEGVPAPRAHSHSPDSFNISWTEPGHPNGVITTYELYLDGTLIHNSSELSCHAYGFDPGSLHTFQVQACTAKGCALGPLVENRTLEAPPEGTVNLFVKPEGSREAAVRWDAPPHPNGRLTYSVLITGNFYADQAGDNYTLLSSTKTVHSSKGDRLWVLVDRLVPCSNYTVQVNASNSQGSVLSDRVSVEMPPGAPDGLLSPRLAAATPTSLQVVWSTPARNNAPGSPRYQLQMRPDPSTRGLLELFPIPSALLSYEVTGLQPFTVYEFRLVATNGFGSAYSDWTPLMTTEDKPGPMDAPVLNVKAGMMSVAWRKPTECNGAITHYNIYQHGRLYLTVSGGVTNCTVVHLRPHTAYQFQIEACSSKGCSMSPASETVWTLPGTPEGIPGPELLPYTPTKIIVSWQPPTHLDGLVENITIERRVKEQEEVRSLVILPRSQAVRFIDNDPALRPWTHYEYRVLGSTLNGGTNSSAWVEVTTRPSRPSGVQPPTVHVLGPDAVEVTWKAPLIRNGDIVSYEIRMPDPLIEITNVTSFVLSHLVKHLIPFTNYSVSIVACSGGHGYLGGCTESLPTFATTHPALPQELTPLSISLLGQSYVGISWQPPSKPNGPNLRYELLRRKIQQPLASNPPEDLNLWHNIYSGTRRFYEDKGLSRFTTYEYKLFVHNSLGFTPSQEVTVTTLAGSPERGATVTASILNHTAIDVRWKRPTFQDLQGDVEYYTLFWSSGTSVESLKIFPDVDFHVIGHLAPNVEYQVFLLVFNGVHAINSTVVRVTTWEEEPRGMRPPEVVIINSTAVRVIWTSPSNPNAVITESSVYANNELHKAGAGAPGSFTLEDLSPFTIYDIQVEVCTKDACVKSSGTQVSTAEDTPSGISIPIIRDITSRSLQIDWTAPGNPNGIILGYDVLRKTWRLCSETQKLTDKPRDELCKAVKCQYPGNVCGHTCYSPGTKVCCDGLLYDPQPGYSCCEEKYIALLPNSTGVCCGGRQREAQPDHQCCSGHYIRILPGEICCPDERHNRVSVGFGDACCGTMPYATSGSQVCCAGKLQDGYRRQCCGGEMVSQDFKCCGGGEEGMVYSSLPGMLCCGQDYVNMSDTICCSASSGDSKAHVRGSDPMPVRCCHTELIPESQQCCDGVGYNPVKYVCSDEISAGMATEETRVCATVCPATMRATAHCGQCDFNATTHICTVSRGPLNPIGKETAEGLCSTAEEIVHSGDENTRSFIDTDLEPSTVYEYRVSVWNSYGRGFSQSVRASTREDVPQGVTAPRWARTGNHEDVIFLTWKEPTQSNGPITHYILLRDGRERFQGAALSFTDTQGIQPLQEYSYQLKACTAAGCADSCKVVATATRGVLESVPPPNITAQSPETLHLSWSVPEKRNDAIKEYQLWLDGKGLIYTDTNDRRQHTVTGLQPHTNYSFTLSACTSVGCTSSEPSVGQTLQAAPQGVWVTPRHIIINSTTVELYWNPPERPNGVISQYRLRRNGSLLLVGGRDDQSFTDKNLEPNSRYIYTLEARTGGGSSLSEEYLVQMPMWTPEDVHPPCNVTVLGSDSIFVAWPAPGILLPKIPVEYSILLSGGNMMLLTFSVGLRQSAYLKNLAPFTQYEIRIQACQEGCGVSPGTHVRTLEAAPVGLMPPLLKALGSHCIEVKWTPPTRPNGIITSYVIHRRPADTEEESLLFVWSEGALEFTDDTDTLRPFTLYEYRVRAWNSKGVVDSPWSSVQTLEAPPQDLPAPWVQVTSAHSVLLNWTEPEAPNGLISQYHVIYQERPDEAAPGSSTVHAFTVKGSSRQAHLFGLEPFTTYHIGVAAVNRAGKVSSPWTLIKTLESAPSGLMNFTAEQREGGRALLLQWSEPVRTNGVIKAYNVFSDGLPEYSGLGRQFLFRRLAPFTLYILTLEACTAAGCAHSVPQTLWTEEAPPDSQMAPTIQSVEPTSVRLHWSQPANPNGKIIRYEVIRRRLQGEDWGNRTVQADENTVFTEYNTEGNGWVCTDTGLQPWGLYSYRICTWNSAGHTCSSWSVVRTSQAPPDGLSPPEVSYVSTSPLQLLISWFAPRHTNGVIQSYRLQRNGVFAAASFNSSTFSYTDGQLLPFTTYSYAVLACTGGGCCTSEPTNITTPEASPAGVSPPVLWAIGAHQINVSWSPPSVPNGKIAKYLLHCDGEEHLAGQDLSLLLSNLRPFTQYNVSLVACTKGGCTASRVASAWTMEAPPEDMDPPTLHVMGPESIEITWAPPRNPHGQIRSYELRRDGAIVYIGLETRYHDFILTPGVQYGYTVTATNSRGSVLSPLVKGQTSPSAPSGLQPPKLRAGEALELLVNWNPPVRTNGKITNYTLFIRELLEGEIRTMCINTTHSSFGTRSLAVKHLKPFHRYEVRVQACTALGCTSSEWTPTQTSEIPPLLQPAPHLEVQTAAGGFQPIVAVWWAGPLQPHGKIVRFELYRRQTASWPGTSSPLLIYNGSLSSFTDRELLPFTEYEYQVWAVNSAGKVASNWTWCRTGPAPPEGLKAPTFHTVSSTQAVVNISAPSKPNGNISLFRVFSNSSGTHVMLSEGMATQQTLHDLRPFTTYAIGVEACTCFNCCSRGPTAELRTHPAPPSGLSPPQVQTLGSRMASFQWAPPQLPNGVIHSYELQLHRACPPDSAPHCPPSPTERKYWGPGHRASLAGLQPNTAYGVQVVAHNEAGSTASGWTSFRTKKEMPQYQALFSVDSNASTVWVDWSGTFVLNGQLKEYVVTDGGRRVYSGLDTTLYIPRTVDKTFFFQVTCTTDIGSVKTPLVQYDATTGFGLVLTTPGGKKGAGTKSTEFYTDTRLPRSGTPVSIRSSQSVSVLRIPSQSQLSHAYSQGSLHRSVSQLMDSPDKKALTEDSLWETIMGHSSGLCVDEEELMNAIKGFSSVTKEHTAFTDTHL
uniprot
proteins
function
FUNCTION: Involved in hearing and vision as member of the USH2 complex. In the inner ear, required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. {ECO:0000250|UniProtKB:Q2QI47}.
uniprot
proteins
mass_dalton
562986
uniprot
proteins
pubmed
12160733
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
16301216
uniprot
proteins
sequence_length
5125
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000250}.; SUBCELLULAR LOCATION: Cell projection, stereocilium membrane {ECO:0000250|UniProtKB:Q2QI47}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q2QI47}. Note=Component of the interstereocilia ankle links in the inner ear sensory cells. In photoreceptors, localizes at a plasma membrane microdomain in the apical inner segment that surrounds the connecting cilia called periciliary membrane complex. {ECO:0000250|UniProtKB:Q2QI47}.
uniprot
proteins