Kcnj1
entrez
56379
canonical
uniprot
O88335
canonical
ensembl
ENSMUSG00000041248
resolver
ensp
ENSMUSP00000046793
resolver
ensp
ENSMUSP00000131625
resolver
ensp
ENSMUSP00000150540
resolver
enst
ENSMUST00000047334
resolver
enst
ENSMUST00000172015
resolver
enst
ENSMUST00000213393
resolver
genesymbol
Kcnj1
resolver
uniprot
G3UWE7
resolver
uniprot_entry
G3UWE7_MOUSE
resolver
uniprot_entry
KCNJ1_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by WNK3. Activated by phosphatidylinositol 4,5 biphosphate (PtdIns(4,5)P2). {ECO:0000250|UniProtKB:P35560, ECO:0000250|UniProtKB:P48048}.
uniprot
proteins
amino_acid_sequence
MFKHLRRWFVTHIFGRSRQRARLVSKDGRCNIEFGNVDAQSRFIFFVDIWTTVLDLKWRYKMTVFITAFLGSWFLFGLLWYVVAYVHKDLPEFYPPDNRTPCVENINGMTSAFLFSLETQVTIGYGFRFVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTITPEGETIILDQTNINFVVDAGNENLFFISPLTIYHIIDHNSPFFHMAAETLSQQDFELVVFLDGTVESTSATCQVRTSYIPEEVLWGYRFVPIVSKTKEGKYRVDFHNFGKTVEVETPHCAMCLYNEKDARARMKRGYDNPNFVLSEVDETDDTQM
uniprot
proteins
function
FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. In the kidney, probably plays a major role in potassium homeostasis. {ECO:0000250|UniProtKB:P48048}.
uniprot
proteins
mass_dalton
42776
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-25 by SGK1 is necessary for its expression at the cell membrane. {ECO:0000250|UniProtKB:P48048}.
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ1 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
372
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P48048}; Multi-pass membrane protein {ECO:0000255}. Note=Phosphorylation at Ser-44 by SGK1 is necessary for its expression at the cell membrane. {ECO:0000250|UniProtKB:P48048}.
uniprot
proteins
transmembrane_region
TRANSMEM 59..83; /note="Helical; Name=M1"; /evidence="ECO:0000250"; TRANSMEM 137..158; /note="Helical; Name=M2"; /evidence="ECO:0000250
uniprot
proteins