Sox4
entrez
20677
canonical
uniprot
Q06831
canonical
ensembl
ENSMUSG00000076431
resolver
ensp
ENSMUSP00000100013
resolver
enst
ENSMUST00000067230
resolver
genesymbol
Sox4
resolver
genesymbol_syn
Sox-4
resolver
uniprot
Q5SW95
resolver
uniprot_entry
SOX4_MOUSE
resolver
uniprot_sec
Q5SW95
resolver
amino_acid_sequence
MVQQTNNAENTEALLAGESSDSGAGLELGIASSPTPGSTASTGGKADDPSWCKTPSGHIKRPMNAFMVWSQIERRKIMEQSPDMHNAEISKRLGKRWKLLKDSDKIPFIQEAERLRLKHMADYPDYKYRPRKKVKSGNAGAGSAATAKPGEKGDKVAGSSGHAGSSHAGGGAGGSSKPAPKKSCGPKVAGSSVGKPHAKLVPAGGSKAAASFSPEQAALLPLGEPTAVYKVRTPSAATPAASSSPSSALATPAKHPADKKVKRVYLFGSLGASASPVGGLGASADPSDPLGLYEDGGPGCSPDGRSLSGRSSAASSPAASRSPADHRGYASLRAASPAPSSAPSHASSSLSSSSSSSSGSSSSDDEFEDDLLDLNPSSNFESMSLGSFSSSSALDRDLDFNFEPGSGSHFEFPDYCTPEVSEMISGDWLESSISNLVFTY
uniprot
proteins
function
FUNCTION: Transcriptional activator that binds with high affinity to the T-cell enhancer motif 5'-AACAAAG-3' motif (PubMed:8404853). Required for IL17A-producing Vgamma2-positive gamma-delta T-cell maturation and development, via binding to regulator loci of RORC to modulate expression (PubMed:23562159). Involved in skeletal myoblast differentiation by promoting gene expression of CALD1 (PubMed:26291311). {ECO:0000269|PubMed:23562159, ECO:0000269|PubMed:26291311, ECO:0000269|PubMed:8404853}.
uniprot
proteins
mass_dalton
45044
uniprot
proteins
post_translational_modification
PTM: Acetylation at Lys-95 by KAT5 promotes the transcription activator activity and is required during myoblast differentiation (By similarity). Acetylation by KAT5 abolishes the interaction between SOX4 and HDAC1 and switches SOX4 into a transcriptional activator (By similarity). {ECO:0000250|UniProtKB:Q06945}.
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17218525
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23562159
uniprot
proteins
pubmed
26291311
uniprot
proteins
pubmed
8404853
uniprot
proteins
pubmed
8493110
uniprot
proteins
pubmed
8921394
uniprot
proteins
sequence_length
440
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q06945}.
uniprot
proteins