Adrm1
entrez
65138
canonical
uniprot
Q9JMB5
canonical
ensembl
ENSRNOG00000055984
resolver
ensp
ENSRNOP00000086833
resolver
genesymbol
Adrm1
resolver
genesymbol_syn
Gp110
resolver
uniprot
Q6P795
resolver
uniprot_entry
ADRM1_RAT
resolver
uniprot_sec
Q6P795
resolver
amino_acid_sequence
MTTSGALFPSLVPGSRGSSTKYLVEFRAGKMSLKGTTVTPDKRKGLVYIQQTDDSLIHFCWKDRTSGTVEDDLIIFPDDCEFKRVPQCPSGRVYVLKFKAGSKRLFFWMQEPKTDQDEEHCRKVNECLNNPPMPGTLGASGSSGHELSALGGEGGLQSLLGNMSHSQLMQLIGPAGLGGLGGLGALTGPGLASLLGSSGPPASSSSSSSRSQSAAVTPSSTTSSARATPAPSAPAAASATSPSPAPSSGNGTSTAASPTQPIQLSDLQSILATMNVPAGPGGSQQVDLASVLTPEIMAPILANADVQERLLPYLPSGESLPQTAEEIQNTLTSPQFQQALGMFSAALASGQLGPLMCQFGLPAEAVEAANKGDVEAFAKAMQNNAKSDPKEGDTKDKKDEEEDMSLD
uniprot
proteins
function
FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex. {ECO:0000250|UniProtKB:Q16186}.
uniprot
proteins
mass_dalton
42102
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by UBE3C in response to proteotoxic stress. {ECO:0000250|UniProtKB:Q16186}.
uniprot
proteins
protein_family
ADRM1 family
uniprot
proteins
pubmed
11018266
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
407
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q16186}. Nucleus {ECO:0000250|UniProtKB:Q16186}.
uniprot
proteins