Ptf1a
entrez
19213
canonical
uniprot
Q9QX98
canonical
ensembl
ENSMUSG00000026735
resolver
ensp
ENSMUSP00000028068
resolver
enst
ENSMUST00000028068
resolver
genesymbol
Ptf1a
resolver
genesymbol_syn
Ptf1p48
resolver
uniprot
A2ATA7
resolver
uniprot
Q9QYF5
resolver
uniprot
Q9QYF6
resolver
uniprot_entry
A2ATA7_MOUSE
resolver
uniprot_entry
PTF1A_MOUSE
resolver
uniprot_sec
Q9QYF5
resolver
uniprot_sec
Q9QYF6
resolver
amino_acid_sequence
MDAVLLEHFPGGLDTFPSPYFDEEDFFTDQSSRDPLEDSDELLGDEQAEVEFLSHQLHEYCYRDGACLLLQPAPSAAPHALAPPPLGDPGEPEDNVSYCCDAGAPLAAFPYSPGSPPSCLAYPCAAVLSPGARLGGLNGAAAAAAARRRRRVRSEAELQQLRQAANVRERRRMQSINDAFEGLRSHIPTLPYEKRLSKVDTLRLAIGYINFLSELVQADLPLRGSGAGGCGGPGGSRHLGEDSPGNQAQKVIICHRGTRSPSPSDPDYGLPPLAGHSLSWTDEKQLKEQNIIRTAKVWTPEDPRKLNSKSFDNIENEPPFEFVS
uniprot
proteins
function
FUNCTION: Transcription factor implicated in the cell fate determination in various organs (PubMed:11562365, PubMed:12185368, PubMed:15543146, PubMed:17075007, PubMed:9851981). Binds to the E-box consensus sequence 5'-CANNTG-3' (PubMed:11562365, PubMed:12185368, PubMed:9851981). Plays a role in early and late pancreas development and differentiation (PubMed:11562365, PubMed:21852532). Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates (PubMed:11562365, PubMed:12185368, PubMed:9851981). May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase (PubMed:11562365, PubMed:12185368, PubMed:9851981). Required for the formation of pancreatic acinar and ductal cells (PubMed:11562365). Plays an important role in cerebellar development (PubMed:15543146). Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates (PubMed:17075007). {ECO:0000269|PubMed:11562365, ECO:0000269|PubMed:12185368, ECO:0000269|PubMed:15543146, ECO:0000269|PubMed:17075007, ECO:0000269|PubMed:21852532, ECO:0000269|PubMed:9851981}.
uniprot
proteins
mass_dalton
35185
uniprot
proteins
pubmed
11318877
uniprot
proteins
pubmed
11562365
uniprot
proteins
pubmed
12185368
uniprot
proteins
pubmed
15543146
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17075007
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21852532
uniprot
proteins
pubmed
9851981
uniprot
proteins
sequence_length
324
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=In the cytoplasm loses its ability to form the PTF1 complex.
uniprot
proteins