Rnf186
entrez
66825
canonical
uniprot
Q9D241
canonical
ensembl
ENSMUSG00000070661
resolver
ensp
ENSMUSP00000111780
resolver
ensp
ENSMUSP00000159341
resolver
enst
ENSMUST00000116094
resolver
enst
ENSMUST00000239443
resolver
genesymbol
Rnf186
resolver
uniprot
A2ALL3
resolver
uniprot
Q78R58
resolver
uniprot_entry
A2ALL3_MOUSE
resolver
uniprot_entry
RN186_MOUSE
resolver
uniprot_sec
Q78R58
resolver
amino_acid_sequence
MSCTEAPQPIPAGTTTTSTIIALGPTGRLSISVEGDLECLVCREPYNCARSPKLLSCQHTFCAVCLKLLLYVQEDTWSIPCPLCRKVTAVPGGLICSLRDQEAMVGRLALPCPEVRLCPQRLVGSAASATRPANWTGEEEQDTVSVNRVAARRLAVHLLLLALVIVLILPFIYPGVIRWVLAFVIALALLMSTLFCCHPQSQNSNWLCPRTLFCREQKQTQITSIA
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin protein ligase that is part of an apoptotic signaling pathway activated by endoplasmic reticulum stress. Stimulates the expression of proteins specific of the unfolded protein response (UPR), ubiquitinates BNIP1 and regulates its localization to the mitochondrion and induces calcium release from the endoplasmic reticulum that ultimately leads to cell apoptosis. Plays a role in the maintenance of intestinal homeostasis and clearance of enteric pathogens (PubMed:34623328). Upon NOD2 stimulation, ubiquitinates the ER stress sensor activating transcription factor 6/ATF6 and promotes the unfolded protein response UPR. Participates in basal level of autophagy maintenance by regulating the ubiquitination of EPHB2. Upon stimulation by ligand EFNB1, ubiquitinates EPHB2 and further recruits MAP1LC3B for autophagy induction (PubMed:33280498). Controls nutrient sensing by ubiquitinating Sestrin-2/SESN2, which is an intracellular sensor of cytosolic leucine and inhibitor of mTORC1 activity. {ECO:0000250|UniProtKB:Q9NXI6, ECO:0000269|PubMed:33280498, ECO:0000269|PubMed:34623328}.
uniprot
proteins
mass_dalton
24704
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9NXI6}.
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated. 'Lys-29'-linked autoubiquitination leads to proteasomal degradation. {ECO:0000250|UniProtKB:Q9NXI6}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
33280498
uniprot
proteins
pubmed
34623328
uniprot
proteins
sequence_length
226
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9NXI6}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 157..177; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 179..199; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins