Opn4
entrez
30044
canonical
uniprot
Q9QXZ9
canonical
ensembl
ENSMUSG00000021799
resolver
ensp
ENSMUSP00000022331
resolver
ensp
ENSMUSP00000126136
resolver
genesymbol
Opn4
resolver
genesymbol_syn
Mop
resolver
genesymbol_syn
Mopn
resolver
uniprot
A4QPG3
resolver
uniprot
B2C712
resolver
uniprot_entry
OPN4_MOUSE
resolver
uniprot_sec
A4QPG3
resolver
uniprot_sec
B2C712
resolver
amino_acid_sequence
MDSPSGPRVLSSLTQDPSFTTSPALQGIWNGTQNVSVRAQLLSVSPTTSAHQAAAWVPFPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCRNRGLRTPANMFIINLAVSDFLMSVTQAPVFFASSLYKKWLFGETGCEFYAFCGAVFGITSMITLTAIAMDRYLVITRPLATIGRGSKRRTALVLLGVWLYALAWSLPPFFGWSAYVPEGLLTSCSWDYMTFTPQVRAYTMLLFCFVFFLPLLIIIFCYIFIFRAIRETGRACEGCGESPLRQRRQWQRLQSEWKMAKVALIVILLFVLSWAPYSTVALVAFAGYSHILTPYMSSVPAVIAKASAIHNPIIYAITHPKYRVAIAQHLPCLGVLLGVSGQRSHPSLSYRSTHRSTLSSQSSDLSWISGRKRQESLGSESEVGWTDTETTAAWGAAQQASGQSFCSQNLEDGELKASSSPQVQRSKTPKVPGPSTCRPMKGQGARPSSLRGDQKGRLAVCTGLSECPHPHTSQFPLAFLEDDVTLRHL
uniprot
proteins
function
FUNCTION: G protein-coupled photoreceptor that signals through the G(q/11) family of G proteins in response to light in intrinsically photosensitive retinal ganglion cells (ipRGCs) (PubMed:22051675, PubMed:30017393). Can also activate other G proteins, including G(i/o) and G(s), depending on the cell type, leading to either activation or inhibition of adenylate cyclase and cAMP-dependent signaling (PubMed:35274137). Activation occurs when opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers a G protein-mediated phototransduction cascade (PubMed:19793992). Acts as a bistable protein, allowing photoreversible regeneration of the cis-retinal chromophore after stimulation (By similarity). Contributes to non-image-forming visual response to light in ipRGCs, including the pupillary light reflex and the regulation of circadian rhythms (PubMed:12808468, PubMed:22051675). In M1 ipRGCs (non-image forming) subtypes, activates a G(q)-phospholipase C (PLC) signaling cascade leading to depolarization through opening of TRPC6/7 channels and decreased intrisic excitability (PubMed:22051675, PubMed:30017393). Mediates phototransduction in M4 ipRGCs (image forming) subtypes across dim to bright light conditions via G(q)-PLC signaling, resulting in increased intrisic excitability through closure of potassium leak channels (most likely TASK channels), thereby enhancing contrast sensitivity (PubMed:30017393). At bright light intensities, further enhances depolarization in M4 ipRGCs via activation of TRPC channels (PubMed:30017393). Functions in the iris to control the intrinsic pupillary light reflex in nocturnal/crepuscular non-primate mammals (PubMed:22051675). May be involved in the optokinetic visual tracking response (PubMed:26392540). May also play a role in regulating retinal hyaloid vessel growth and regression (PubMed:30936473). {ECO:0000250|UniProtKB:Q9UHM6, ECO:0000269|PubMed:12808468, ECO:0000269|PubMed:19793992, ECO:0000269|PubMed:22051675, ECO:0000269|PubMed:26392540, ECO:0000269|PubMed:30017393, ECO:0000269|PubMed:30936473, ECO:0000269|PubMed:35274137}.
uniprot
proteins
mass_dalton
57231
uniprot
proteins
post_translational_modification
PTM: Contains one retinal chromophore covalently bound to a lysine residue via a Schiff base. Upon light absorption, the bound 11-cis-retinal isomerizes to all-trans-retinal. Following light exposure, all-trans-retinal is photoreconverted to 11-cis-retinal. {ECO:0000250|UniProtKB:Q9UHM6}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Opsin subfamily
uniprot
proteins
pubmed
10632589
uniprot
proteins
pubmed
11834834
uniprot
proteins
pubmed
12808468
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19793992
uniprot
proteins
pubmed
22051675
uniprot
proteins
pubmed
26392540
uniprot
proteins
pubmed
30017393
uniprot
proteins
pubmed
30240620
uniprot
proteins
pubmed
30936473
uniprot
proteins
pubmed
31607531
uniprot
proteins
pubmed
35274137
uniprot
proteins
sequence_length
521
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19793992, ECO:0000269|PubMed:35274137}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000269|PubMed:11834834}. Cell projection, dendrite {ECO:0000269|PubMed:11834834}. Perikaryon {ECO:0000269|PubMed:11834834}.
uniprot
proteins
transmembrane_region
TRANSMEM 72..92; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 107..127; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 144..164; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 188..208; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 238..258; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 294..314; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 330..350; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins