Mgll
entrez
23945
canonical
uniprot
O35678
canonical
ensembl
ENSMUSG00000033174
resolver
ensp
ENSMUSP00000109211
resolver
ensp
ENSMUSP00000109212
resolver
ensp
ENSMUSP00000109215
resolver
ensp
ENSMUSP00000127374
resolver
ensp
ENSMUSP00000206912
resolver
ensp
ENSMUSP00000206915
resolver
enst
ENSMUST00000113581
resolver
enst
ENSMUST00000113582
resolver
enst
ENSMUST00000163271
resolver
genesymbol
Mgll
resolver
uniprot
D3YYS6
resolver
uniprot
E9Q3B9
resolver
uniprot
F6W9Z9
resolver
uniprot
Q3UFN1
resolver
uniprot
Q3V2R0
resolver
uniprot
Q9D9G8
resolver
uniprot_entry
D3YYS6_MOUSE
resolver
uniprot_entry
E9Q3B9_MOUSE
resolver
uniprot_entry
F6W9Z9_MOUSE
resolver
uniprot_entry
MGLL_MOUSE
resolver
uniprot_entry
Q3UFN1_MOUSE
resolver
uniprot_sec
Q3V2R0
resolver
uniprot_sec
Q9D9G8
resolver
amino_acid_sequence
MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAHMLKGLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDVLQHVDTIQKDYPDVPIFLLGHSMGGAISILVAAERPTYFSGMVLISPLVLANPESASTLKVLAAKLLNFVLPNMTLGRIDSSVLSRNKSEVDLYNSDPLVCRAGLKVCFGIQLLNAVARVERAMPRLTLPFLLLQGSADRLCDSKGAYLLMESSRSQDKTLKMYEGAYHVLHRELPEVTNSVLHEVNSWVSHRIAAAGAGCPP
uniprot
proteins
ec_number
3.1.1.23
uniprot
proteins
function
FUNCTION: Converts monoacylglycerides to free fatty acids and glycerol (PubMed:17700715, PubMed:18096503, PubMed:19029917, PubMed:20554061, PubMed:20729846, PubMed:21454566, PubMed:9341166). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (PubMed:17700715, PubMed:18096503, PubMed:19029917, PubMed:20554061, PubMed:20729846, PubMed:21454566, PubMed:9341166). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (By similarity). {ECO:0000250|UniProtKB:Q99685, ECO:0000269|PubMed:17700715, ECO:0000269|PubMed:18096503, ECO:0000269|PubMed:19029917, ECO:0000269|PubMed:20554061, ECO:0000269|PubMed:20729846, ECO:0000269|PubMed:21454566, ECO:0000269|PubMed:9341166}.
uniprot
proteins
mass_dalton
33388
uniprot
proteins
mutagenesis
MUTAGEN 122; /note="S->A: Abolishes activity."; /evidence="ECO:0000269|PubMed:9341166"; MUTAGEN 239; /note="D->A: Abolishes activity."; /evidence="ECO:0000269|PubMed:9341166"; MUTAGEN 243; /note="D->A: Slightly reduces activity."; /evidence="ECO:0000269|PubMed:9341166"; MUTAGEN 269; /note="H->A: Abolishes activity."; /evidence="ECO:0000269|PubMed:9341166"; MUTAGEN 272; /note="H->A: Reduces activity."; /evidence="ECO:0000269|PubMed:9341166"; MUTAGEN 284; /note="H->A: Slightly reduces activity."; /evidence="ECO:0000269|PubMed:9341166"; MUTAGEN 292; /note="H->A: Slightly reduces activity."; /evidence="ECO:0000269|PubMed:9341166
uniprot
proteins
pathway_participation
PATHWAY: Glycerolipid metabolism; triacylglycerol degradation. {ECO:0000269|PubMed:18096503, ECO:0000269|PubMed:9341166}.
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
protein_family
Monoacylglycerol lipase family
uniprot
proteins
pubmed
11470505
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16800626
uniprot
proteins
pubmed
17700715
uniprot
proteins
pubmed
18096503
uniprot
proteins
pubmed
19029917
uniprot
proteins
pubmed
20554061
uniprot
proteins
pubmed
20729846
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21454566
uniprot
proteins
pubmed
9341166
uniprot
proteins
sequence_length
303
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18096503}. Membrane; Peripheral membrane protein {ECO:0000269|PubMed:18096503}.
uniprot
proteins