Thap11
entrez
59016
canonical
uniprot
Q9JJD0
canonical
ensembl
ENSMUSG00000036442
resolver
ensp
ENSMUSP00000048994
resolver
enst
ENSMUST00000040445
resolver
genesymbol
Thap11
resolver
uniprot
Q3TCZ5
resolver
uniprot
Q99KZ0
resolver
uniprot_entry
THA11_MOUSE
resolver
uniprot_sec
Q3TCZ5
resolver
uniprot_sec
Q99KZ0
resolver
amino_acid_sequence
MPGFTCCVPGCYNNSHRDKALHFYTFPKDAELRRLWLKNVSRAGVSGCFSTFQPTTGHRLCSVHFQGGRKTYTVRVPTIFPLRGVNERKVARRPAGAAAARRRQQQQQQQQQQQQQQQLQQQQPSPSSSTAQTTQLQPNLVSASAAVLLTLQAAVDSNQAPGSVVPVSTTPSGDDVKPIDLTVQVEFAAAEGAAAAAAASELEAATAGLEAAECTLGPQLVVVGEEGFPDTGSDHSYSLSSGTTEEELLRKLNEQRDILALMEVKMKEMKGSIRHLRLTEAKLREELREKDRLLAMAVIRKKHGM
uniprot
proteins
function
FUNCTION: Transcriptional repressor that plays a central role for embryogenesis and the pluripotency of embryonic stem (ES) cells. Sequence-specific DNA-binding factor that represses gene expression in pluripotent ES cells by directly binding to key genetic loci and recruiting epigenetic modifiers (PubMed:18585351). Required for normal brain development and neural precursor differentiation (By similarity). {ECO:0000250|UniProtKB:Q6TGZ4, ECO:0000269|PubMed:18585351}.; FUNCTION: Transcription factor, which has both transcriptional activation and repression activities (PubMed:18585351, PubMed:26876175, PubMed:34515391). Also modulates chromatin accessibility (By similarity). In complex with HCFC1 and ZNF143, regulates the expression of several genes, including AP2S1, ESCO2, OPHN1, RBL1, UBXN8 and ZNF32 (By similarity). May regulate the expression of genes that encode both cytoplasmic and mitochondrial ribosomal proteins (PubMed:34515391). Required for normal mitochondrial development and function. Regulates mitochondrial gene expression, including that of components of the electron transport chain (PubMed:26876175, PubMed:34515391). Involved in the maintainance of pluripotency in early embryonic cells, possibly through its action on mitochondrial maturation which is required to meet high energy demands of these cells (PubMed:18585351, PubMed:34515391). Required for early development of retina, preventing premature exit of retinal progenitor cells from the cell cycle. This effect may also be mediated by its action on mitochondria (PubMed:26876175). Through the regulation of MMACHC gene expression, controls cobalamin metabolism (By similarity). Required for normal brain development and neural precursor differentiation (By similarity). Involved in cell growth (By similarity). {ECO:0000250|UniProtKB:Q6TGZ4, ECO:0000250|UniProtKB:Q96EK4, ECO:0000269|PubMed:18585351, ECO:0000269|PubMed:26876175, ECO:0000269|PubMed:34515391}.
uniprot
proteins
mass_dalton
33276
uniprot
proteins
protein_family
THAP11 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18585351
uniprot
proteins
pubmed
26876175
uniprot
proteins
pubmed
34515391
uniprot
proteins
sequence_length
305
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18585351, ECO:0000269|PubMed:34515391}. Cytoplasm {ECO:0000269|PubMed:18585351}. Note=In oocytes, detected in the ooplasm, without evidence of its presence in the nucleus. Found in the nucleus of undifferentiated embryonic stem cells (PubMed:18585351). Evenly distributed between nucleus and cytoplasm in skin fibroblasts (By similarity). {ECO:0000250|UniProtKB:Q96EK4, ECO:0000269|PubMed:18585351}.
uniprot
proteins