GPR31
entrez
2853
canonical
uniprot
O00270
canonical
ensembl
ENSG00000120436
resolver
ensp
ENSP00000355799
resolver
enst
ENST00000366834
resolver
genesymbol
GPR31
resolver
hgnc
HGNC:4486
resolver
uniprot
B0M0K2
resolver
uniprot
Q4VBL3
resolver
uniprot
Q9NQ20
resolver
uniprot_entry
GPR31_HUMAN
resolver
uniprot_sec
B0M0K2
resolver
uniprot_sec
Q4VBL3
resolver
uniprot_sec
Q9NQ20
resolver
amino_acid_sequence
MPFPNCSAPSTVVATAVGVLLGLECGLGLLGNAVALWTFLFRVRVWKPYAVYLLNLALADLLLAACLPFLAAFYLSLQAWHLGRVGCWALHFLLDLSRSVGMAFLAAVALDRYLRVVHPRLKVNLLSPQAALGVSGLVWLLMVALTCPGLLISEAAQNSTRCHSFYSRADGSFSIIWQEALSCLQFVLPFGLIVFCNAGIIRALQKRLREPEKQPKLQRAQALVTLVVVLFALCFLPCFLARVLMHIFQNLGSCRALCAVAHTSDVTGSLTYLHSVLNPVVYCFSSPTFRSSYRRVFHTLRGKGQAAEPPDFNPRDSYS
uniprot
proteins
function
FUNCTION: High-affinity receptor for 12-(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12-S-HETE), with much lower affinities for other HETE isomers (PubMed:21712392, PubMed:29227475). 12-S-HETE is a eicosanoid, a 12-lipoxygenase (ALOX12) metabolite of arachidonic acid, involved in many physiologic and pathologic processes (PubMed:26965684, PubMed:28619714, PubMed:29227475). 12-S-HETE-binding leads to activation of ERK1/2 (MAPK3/MAPK1), MEK, and NF-kappa-B pathways leading to cell growth (PubMed:21712392, PubMed:29227475). Plays a crucial role for proliferation, survival and macropinocytosis of KRAS-dependent cancer cells by mediating the translocation of KRAS from the endoplasmic reticulum to the plasma membrane (PM) and its association with the PM (PubMed:28619714). Contributes to enhanced immune responses by inducing dendrite protrusion of small intestinal CX3CR1(+) phagocytes for the uptake of luminal antigens (By similarity). Acts also as a key receptor for 12-(S)-HETE-mediated liver ischemia reperfusion injury (PubMed:29227475). {ECO:0000250|UniProtKB:F8VQN3, ECO:0000269|PubMed:21712392, ECO:0000269|PubMed:26965684, ECO:0000269|PubMed:28619714, ECO:0000269|PubMed:29227475}.; FUNCTION: Proton-sensing G protein-coupled receptor. {ECO:0000269|PubMed:31119277}.
uniprot
proteins
mass_dalton
35075
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21712392
uniprot
proteins
pubmed
26965684
uniprot
proteins
pubmed
28619714
uniprot
proteins
pubmed
29227475
uniprot
proteins
pubmed
31119277
uniprot
proteins
pubmed
9205127
uniprot
proteins
sequence_length
319
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21712392, ECO:0000269|PubMed:28619714, ECO:0000269|PubMed:31119277}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 17..37; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 53..73; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 92..110; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 132..152; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 181..201; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 220..240; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 266..284; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins