PARP16
entrez
54956
canonical
uniprot
Q8N5Y8
canonical
ensembl
ENSG00000138617
resolver
ensp
ENSP00000261888
resolver
ensp
ENSP00000396118
resolver
ensp
ENSP00000496935
resolver
ensp
ENSP00000576536
resolver
ensp
ENSP00000576537
resolver
ensp
ENSP00000576538
resolver
ensp
ENSP00000576540
resolver
ensp
ENSP00000576541
resolver
ensp
ENSP00000576542
resolver
ensp
ENSP00000664900
resolver
ensp
ENSP00000664901
resolver
ensp
ENSP00000664902
resolver
ensp
ENSP00000709347
resolver
ensp
ENSP00000709348
resolver
genesymbol
PARP16
resolver
genesymbol_syn
ARTD15
resolver
genesymbol_syn
C15orf30
resolver
hgnc
HGNC:26040
resolver
uniprot
A0A024R5Y7
resolver
uniprot
Q6PK64
resolver
uniprot
Q9NX03
resolver
uniprot_entry
PAR16_HUMAN
resolver
uniprot_sec
A0A024R5Y7
resolver
uniprot_sec
Q6PK64
resolver
uniprot_sec
Q9NX03
resolver
activity_regulation
ACTIVITY REGULATION: In absence of activation signal, PARP16 is autoinhibited by the PARP alpha-helical domain (also named HD region), which prevents effective NAD(+)-binding (By similarity). Activity is highly stimulated by signals, which unfold the PARP alpha-helical domain, relieving autoinhibition (By similarity). {ECO:0000250|UniProtKB:Q9UGN5}.
uniprot
proteins
amino_acid_sequence
MQPSGWAAAREAAGRDMLAADLRCSLFASALQSYKRDSVLRPFPASYARGDCKDFEALLADASKLPNLKELLQSSGDNHKRAWDLVSWILSSKVLTIHSAGKAEFEKIQKLTGAPHTPVPAPDFLFEIEYFDPANAKFYETKGERDLIYAFHGSRLENFHSIIHNGLHCHLNKTSLFGEGTYLTSDLSLALIYSPHGHGWQHSLLGPILSCVAVCEVIDHPDVKCQTKKKDSKEIDRRRARIKHSEGGDIPPKYFVVTNNQLLRVKYLLVYSQKPPKRASSQLSWFSSHWFTVMISLYLLLLLIVSVINSSAFQHFWNRAKR
uniprot
proteins
ec_number
2.4.2.-
uniprot
proteins
function
FUNCTION: Intracellular mono-ADP-ribosyltransferase that plays a role in different processes, such as protein translation and unfolded protein response (UPR), through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:22701565, PubMed:23103912, PubMed:25043379, PubMed:34314702). Acts as an inhibitor of protein translation by catalyzing mono-ADP-ribosylation of ribosomal subunits, such as RPL14 and RPS6, thereby inhibiting polysome assembly and mRNA loading (PubMed:34314702). Mono-ADP-ribosylation of ribosomal subunits is promoted by NMNAT2 (PubMed:34314702). Involved in the unfolded protein response (UPR) by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors (PubMed:23103912). May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor (PubMed:22701565). May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases (PubMed:22701565). {ECO:0000269|PubMed:22701565, ECO:0000269|PubMed:23103912, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:34314702}.
uniprot
proteins
mass_dalton
36383
uniprot
proteins
mutagenesis
MUTAGEN 152; /note="H->A: Loss of ADP-ribosyltransferase activity; when associated with A-254."; /evidence="ECO:0000269|PubMed:22701565"; MUTAGEN 152; /note="H->Q: ADP-ribosyltransferase activity is only 6% of wild-type; when associated with A-182."; /evidence="ECO:0000269|PubMed:23103912"; MUTAGEN 182; /note="Y->A: ADP-ribosyltransferase activity is only 6% of wild-type; when associated with Q-152."; /evidence="ECO:0000269|PubMed:23103912"; MUTAGEN 254; /note="Y->A: Loss of ADP-ribosyltransferase activity; when associated with H-152."; /evidence="ECO:0000269|PubMed:22701565
uniprot
proteins
post_translational_modification
PTM: Auto-mono-ADP-ribosylated. {ECO:0000269|PubMed:22661712, ECO:0000269|PubMed:22701565, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:34314702}.
uniprot
proteins
protein_family
ARTD/PARP family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
20106667
uniprot
proteins
pubmed
22661712
uniprot
proteins
pubmed
22701565
uniprot
proteins
pubmed
23103912
uniprot
proteins
pubmed
25043379
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
34314702
uniprot
proteins
sequence_length
322
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23103912}; Single-pass type IV membrane protein {ECO:0000269|PubMed:22701565}.
uniprot
proteins
transmembrane_region
TRANSMEM 288..308; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins