HLF
entrez
3131
canonical
uniprot
Q16534
canonical
ensembl
ENSG00000108924
resolver
ensp
ENSP00000226067
resolver
ensp
ENSP00000460296
resolver
ensp
ENSP00000461455
resolver
genesymbol
HLF
resolver
hgnc
HGNC:4977
resolver
uniprot
A8K1X8
resolver
uniprot
Q6FHS9
resolver
uniprot_entry
HLF_HUMAN
resolver
uniprot_sec
A8K1X8
resolver
uniprot_sec
Q6FHS9
resolver
amino_acid_sequence
MEKMSRPLPLNPTFIPPPYGVLRSLLENPLKLPLHHEDAFSKDKDKEKKLDDESNSPTVPQSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSENGIPPSPSQHDHSPHPPGLQPASSAAPSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEPDPADLALSSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRRKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADLRKELGKCKNILAKYEARHGPL
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving HLF is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(17;19)(q22;p13.3) with TCF3. {ECO:0000269|PubMed:1516826}.
uniprot
proteins
function
FUNCTION: Transcription factor which selectively binds with high affinity to the consensus sequence 5'-GTTACGTAAT-3' and to closely related sites (PubMed:8065331, PubMed:8164688, PubMed:8639829). Has transcriptional activator activity (PubMed:10073576, PubMed:8065331, PubMed:8164688, PubMed:8639829). Also has transcriptional repressor activity (By similarity). Binds to multiple sites in the promoter regions of coagulation factors F8 and F9 and activates transcription; transactivation activity is enhanced by formation of a heterodimer with DBP (PubMed:10073576). Binds to the promoter region of IRF2 and activates transcription (By similarity). Maintains quiescence of hematopoietic stem cells under steady-state conditions and protects the stem cell pool from toxic insults (By similarity). Regulates the tissue residency and proinflammatory function of CD4+ tissue-resident memory T (TRM) cells (By similarity). Down-regulates the expression of genes involved in promoting tissue egress of CD4+ TRM cells including S1PR1, KLF2 and TCF7 while up-regulating expression of tissue retention molecules such as CD69 (By similarity). Also up-regulates BHLHE40 expression, promoting proinflammatory cytokine production (By similarity). {ECO:0000250|UniProtKB:Q8BW74, ECO:0000269|PubMed:10073576, ECO:0000269|PubMed:8065331, ECO:0000269|PubMed:8164688, ECO:0000269|PubMed:8639829}.
uniprot
proteins
mass_dalton
33199
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
protein_family
PAR subfamily
uniprot
proteins
pubmed
10073576
uniprot
proteins
pubmed
1386162
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
1516826
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
8065331
uniprot
proteins
pubmed
8164688
uniprot
proteins
pubmed
8639829
uniprot
proteins
sequence_length
295
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8639829}.
uniprot
proteins