Slc38a5
entrez
209837
canonical
uniprot
Q3U1J0
canonical
ensembl
ENSMUSG00000031170
resolver
ensp
ENSMUSP00000033512
resolver
genesymbol
Slc38a5
resolver
genesymbol_syn
Jm24
resolver
genesymbol_syn
Sn2
resolver
genesymbol_syn
Snat5
resolver
uniprot
Q3TZ39
resolver
uniprot
Q8BJZ6
resolver
uniprot
Q8BW30
resolver
uniprot_entry
S38A5_MOUSE
resolver
uniprot_sec
Q3TZ39
resolver
uniprot_sec
Q8BJZ6
resolver
uniprot_sec
Q8BW30
resolver
activity_regulation
ACTIVITY REGULATION: Not inhibited by lithium (By similarity). Partial allosteric regulation on ions sodium binding (By similarity). {ECO:0000250|UniProtKB:A2VCW5, ECO:0000250|UniProtKB:Q8WUX1}.
uniprot
proteins
amino_acid_sequence
MAISCAVGMEMQEPKMNGTLSAGAAAGYRQEREGFLPTTRNPATGRKPVQFLDFEGKTSFGMSVFNLSNAIMGSGILGLAYAMAHTGVIFFLALLLCIALLSSYSIHLLLTCASVVGIRAYEQLGQRAFGPAGKVVVAIIICLHNVGAMSSYLFIIKSELPLVIGTFLHMDPEGDWFLKGNLLIILVSLLIILPLALMKHLGYLGYTSSLSLTCMLFFLISVIYKKFQIGCDVSHNDTVVEAEQAPLQAFNSSCEAELFTVDSQMSYTVPIMAFAFVCHPEVLPIYTELCRPTQRRMQAVANMSIGAMFIMYGLTATFGYLTFYSTVKAEMLEMYTQEDMLILCVRLAVLLAVTLTVPVVLFPIRRALQQLLFPSKAFSWLRHVAIALILLILVNILVICVPTIRDIFGFIGSTSAPSLIFILPSVFYLRIVPTEVEPLFSWPKIQALCFGVLGVLFMAISLGFMFANWATGQSRMSGH
uniprot
proteins
function
FUNCTION: Symporter that cotransports neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:15489334, PubMed:16249471). Releases L-glutamine and glycine from astroglial cells and may participate in the glutamate/GABA-L-glutamine cycle and the NMDA receptors activation (By similarity). In addition, contributes significantly to L-glutamine uptake in retina, namely in ganglion and Mueller cells therefore, participates in the retinal glutamate-glutamine cycle (PubMed:15489334, PubMed:16249471). The transport activity is pH sensitive, Li(+) tolerant, bidirectional and associated with large uncoupled fluxes of protons (By similarity). Moreover functions in both direction and is associated with large uncoupled fluxes of protons (By similarity). The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (By similarity). May have a particular importance for modulation of net hepatic glutamine flux (By similarity). {ECO:0000250|UniProtKB:A2VCW5, ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:16249471}.
uniprot
proteins
mass_dalton
52617
uniprot
proteins
protein_family
Amino acid/polyamine transporter 2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16249471
uniprot
proteins
pubmed
17032746
uniprot
proteins
pubmed
18689705
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
479
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18689705}; Multi-pass membrane protein {ECO:0000255}. Note=Localized at astroglial membrane. {ECO:0000250|UniProtKB:A2VCW5}.
uniprot
proteins
transmembrane_region
TRANSMEM 62..84; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 98..118; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 136..156; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 177..197; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 203..223; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 265..285; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 303..323; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 342..362; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 384..404; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 407..427; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 447..467; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins