Pdia3
entrez
29468
canonical
uniprot
P11598
canonical
ensembl
ENSRNOG00000015018
resolver
ensembl
ENSRNOG00055002778
resolver
ensembl
ENSRNOG00060015056
resolver
ensembl
ENSRNOG00065027072
resolver
ensp
ENSRNOP00000083210
resolver
ensp
ENSRNOP00055003232
resolver
ensp
ENSRNOP00060020635
resolver
ensp
ENSRNOP00065038283
resolver
enst
ENSRNOT00000113825
resolver
enst
ENSRNOT00055004360
resolver
enst
ENSRNOT00060025815
resolver
enst
ENSRNOT00065046688
resolver
genesymbol
Pdia3
resolver
genesymbol_syn
Erp60
resolver
genesymbol_syn
Grp58
resolver
uniprot
A0A8I6GAH4
resolver
uniprot_entry
A0A8I6GAH4_RAT
resolver
uniprot_entry
PDIA3_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Seems to be inhibited by acidic phospholipids. {ECO:0000269|PubMed:1330685}.
uniprot
proteins
amino_acid_sequence
MRFSCLALLPGVALLLASALLASASDVLELTDENFESRVSDTGSAGLMLVEFFAPWCGHCKRLAPEYEAAATRLKGIVPLAKVDCTANTNTCNKYGVSGYPTLKIFRDGEEAGAYDGPRTADGIVSHLKKQAGPASVPLRTEDEFKKFISDKDASVVGFFRDLFSDGHSEFLKAASNLRDNYRFAHTNVESLVKEYDDNGEGITIFRPLHLANKFEDKIVAYTEKKMTSGKIKKFIQESIFGLCPHMTEDNKDLIQGKDLLTAYYDVDYEKNTKGSNYWRNRVMMVAKTFLDAGHKLNFAVASRKTFSHELSDFGLESTTGEIPVVAIRTAKGEKFVMQEEFSRDGKALERFLQEYFDGNLKRYLKSEPIPETNEGPVKVVVAESFDDIVNAEDKDVLIEFYAPWCGHCKNLEPKYKELGEKLSKDPNIVIAKMDATANDVPSPYEVKGFPTIYFSPANKKLTPKKYEGGRELNDFISYLQREATNPPIIQEEKPKKKKKAQEDL
uniprot
proteins
ec_number
5.3.4.1
uniprot
proteins
function
FUNCTION: Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone. Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity. {ECO:0000250|UniProtKB:P30101}.
uniprot
proteins
mass_dalton
56623
uniprot
proteins
mutagenesis
MUTAGEN 502..505; /note="QEDL->AAGL: Failure to prevent secretion from ER."; /evidence="ECO:0000269|PubMed:9399589"; MUTAGEN 502..505; /note="Missing: Failure to prevent secretion from ER."; /evidence="ECO:0000269|PubMed:9399589
uniprot
proteins
post_translational_modification
PTM: Within the major histocompatibility complex class I (MHC I) peptide loading complex forms reversible disulfide-linked heterodimers with TAPBP as part of its protein folding chaperone activity. This is essential to assist the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. {ECO:0000250|UniProtKB:P30101}.; PTM: Phosphorylated. {ECO:0000250|UniProtKB:P27773}.
uniprot
proteins
protein_family
Protein disulfide isomerase family
uniprot
proteins
pubmed
1321829
uniprot
proteins
pubmed
1330685
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1650195
uniprot
proteins
pubmed
1657921
uniprot
proteins
pubmed
20400973
uniprot
proteins
pubmed
2181662
uniprot
proteins
pubmed
3398923
uniprot
proteins
pubmed
9399589
uniprot
proteins
sequence_length
505
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:P30101}. Endoplasmic reticulum lumen {ECO:0000269|PubMed:9399589}. Melanosome {ECO:0000250|UniProtKB:P30101}.
uniprot
proteins