P30100
uniprot
P30100
canonical
amino_acid_sequence
MALRVTADVWLARPWQCLHRTRALGTTATLAPKTLKPFEAIPQYSRNKWLKMIQILREQGQENLHLEMHQAFQELGPIFRHSAGGAQIVSVMLPEDAEKLHQVESILPRRMHLEPWVAHRELRGLRRGVFLLNGAEWRFNRLKLNPNVLSPKAVQNFVPMVDEVARDFLEALKKKVRQNARGSLTMDVQQSLFNYTIEASNFALFGERLGLLGHDLNPGSLKFIHALHSMFKSTTQLLFLPRSLTRWTSTQVWKEHFDAWDVISEYANRCIWKVHQELRLGSSQTYSGIVAALITQGALPLDAIKANSMKLTAGSVDTTAIPLVMTLFELARNPDVQQALRQETLAAEASIAANPQKAMSDLPLLRAALKETLRLYPVGGFLERILNSDLVLQNYHVPAGTLVLLYLYSMGRNPAVFPRPERYMPQRWLERKRSFQHLAFGFGVRQCLGRRLAEVEMLLLLHHMLKTFQVETLRQEDVQMAYRFVLMPSSSPVLTFRPIS
uniprot
proteins
ec_number
1.14.15.4
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids (PubMed:8674838). Catalyzes the hydroxylation of steroids at 11beta, 18- or 19-positions, with preferred regioselectivity at 11beta and 18 (PubMed:8674838). Converts 11-deoxycorticosterone into corticosterone, 18-hydroxy-11-deoxycorticosterone, and/or 19-hydroxy-11-deoxycorticosterone, but not to 18-hydroxycorticosterone or aldosterone (PubMed:8674838). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate for hydroxylation and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) (By similarity). {ECO:0000250|UniProtKB:P15538, ECO:0000269|PubMed:8674838}.
uniprot
proteins
mass_dalton
57122
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
1562515
uniprot
proteins
pubmed
2129527
uniprot
proteins
pubmed
2350348
uniprot
proteins
pubmed
2738055
uniprot
proteins
pubmed
8468320
uniprot
proteins
pubmed
8473352
uniprot
proteins
pubmed
8674838
uniprot
proteins
sequence_length
500
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion membrane.
uniprot
proteins