MTF2
entrez
22823
canonical
uniprot
Q9Y483
canonical
ensembl
ENSG00000143033
resolver
ensp
ENSP00000359321
resolver
ensp
ENSP00000359326
resolver
ensp
ENSP00000443295
resolver
ensp
ENSP00000444962
resolver
genesymbol
MTF2
resolver
genesymbol_syn
PCL2
resolver
hgnc
HGNC:29535
resolver
uniprot
A6NGQ9
resolver
uniprot
A8K2Q3
resolver
uniprot
B1AKT5
resolver
uniprot
B1AKT6
resolver
uniprot
B4DZ69
resolver
uniprot
B4DZG1
resolver
uniprot
Q7Z534
resolver
uniprot
Q96G26
resolver
uniprot
Q9UES9
resolver
uniprot
Q9UP40
resolver
uniprot_entry
B4DZ69_HUMAN
resolver
uniprot_entry
B4DZG1_HUMAN
resolver
uniprot_entry
MTF2_HUMAN
resolver
uniprot_entry
Q7Z534_HUMAN
resolver
uniprot_sec
A6NGQ9
resolver
uniprot_sec
A8K2Q3
resolver
uniprot_sec
B1AKT5
resolver
uniprot_sec
B1AKT6
resolver
uniprot_sec
Q96G26
resolver
uniprot_sec
Q9UES9
resolver
uniprot_sec
Q9UP40
resolver
amino_acid_sequence
MRDSTGAGNSLVHKRSPLRRNQKTPTSLTKLSLQDGHKAKKPACKFEEGQDVLARWSDGLFYLGTIKKINILKQSCFIIFEDSSKSWVLWKDIQTGATGSGEMVCTICQEEYSEAPNEMVICDKCGQGYHQLCHTPHIDSSVIDSDEKWLCRQCVFATTTKRGGALKKGPNAKALQVMKQTLPYSVADLEWDAGHKTNVQQCYCYCGGPGDWYLKMLQCCKCKQWFHEACVQCLQKPMLFGDRFYTFICSVCSSGPEYLKRLPLQWVDIAHLCLYNLSVIHKKKYFDSELELMTYINENWDRLHPGELADTPKSERYEHVLEALNDYKTMFMSGKEIKKKKHLFGLRIRVPPVPPNVAFKAEKEPEGTSHEFKIKGRKASKPISDSREVSNGIEKKGKKKSVGRPPGPYTRKMIQKTAEPLLDKESISENPTLDLPCSIGRTEGTAHSSNTSDVDFTGASSAKETTSSSISRHYGLSDSRKRTRTGRSWPAAIPHLRRRRGRLPRRALQTQNSEIVKDDEGKEDYQFDELNTEILNNLADQELQLNHLKNSITSYFGAAGRIACGEKYRVLARRVTLDGKVQYLVEWEGATAS
uniprot
proteins
function
FUNCTION: Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:23142980, PubMed:23228662, PubMed:31959557). Regulates the transcriptional networks during embryonic stem cell self-renewal and differentiation (By similarity). Promotes recruitment of the PRC2 complex to the inactive X chromosome in differentiating XX ES cells and PRC2 recruitment to target genes in undifferentiated ES cells (By similarity). Required to repress Hox genes by enhancing H3K27me3 methylation of the PRC2 complex (By similarity). In some conditions may act as an inhibitor of PRC2 activity: able to activate the CDKN2A gene and promote cellular senescence by suppressing the catalytic activity of the PRC2 complex locally (By similarity). Binds to the metal-regulating-element (MRE) of MT1A gene promoter (By similarity). {ECO:0000250|UniProtKB:Q02395, ECO:0000269|PubMed:23142980, ECO:0000269|PubMed:23228662, ECO:0000269|PubMed:31959557}.
uniprot
proteins
mass_dalton
67090
uniprot
proteins
mutagenesis
MUTAGEN 338..339; /note="KK->AA: Abolishes chromatin binding activity of the PRC2.1 complex."; /evidence="ECO:0000269|PubMed:31959557"; MUTAGEN 544..557; /note="Missing: Reduced chromatin binding activity of the PRC2.1 complex, probably due to loss of dimer stability."; /evidence="ECO:0000269|PubMed:31959557
uniprot
proteins
protein_family
Polycomblike family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
23142980
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23228662
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
31959557
uniprot
proteins
sequence_length
593
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31959557}. Note=Localizes to chromatin as part of the PRC2 complex. {ECO:0000269|PubMed:31959557}.
uniprot
proteins