Dram2
entrez
362011
canonical
uniprot
Q5BK09
canonical
ensembl
ENSRNOG00000017744
resolver
ensembl
ENSRNOG00055019702
resolver
ensembl
ENSRNOG00060029247
resolver
ensembl
ENSRNOG00065022865
resolver
ensp
ENSRNOP00000023903
resolver
ensp
ENSRNOP00055027262
resolver
ensp
ENSRNOP00060042218
resolver
ensp
ENSRNOP00065031728
resolver
enst
ENSRNOT00000023903
resolver
enst
ENSRNOT00055033612
resolver
enst
ENSRNOT00060050752
resolver
enst
ENSRNOT00065039073
resolver
genesymbol
Dram2
resolver
genesymbol_syn
Tmem77
resolver
uniprot_entry
DRAM2_RAT
resolver
amino_acid_sequence
MWWFQQGLSFLPSALVIWTFATFIFSYITAITLHHVDPALPYISDTGTMPPERCLFGVMLNIAAVLGIATIYVRYKQVHALNPEENLIIKLNKAGLVLGILSCLGLSLVANFQKSALFIVHVCGAVLAFSMGSFYMFVQTILSYQMQPKIHSKQVFWVRLLLVIWCGVSALSMMTCSSILYSSDFGADIVQKLHWNPEDKGYVLHIVTTAAEWSMSFSFFGFFLTYIRDFQKITLRVEANLHGLTLYDTVPCPVTNERTPLLSRDFQ
uniprot
proteins
function
FUNCTION: Plays a role in the initiation of autophagy. In the retina, might be involved in the process of photoreceptor cells renewal and recycling to preserve visual function. Induces apoptotic cell death when coexpressed with DRAM1. {ECO:0000250|UniProtKB:Q6UX65}.
uniprot
proteins
mass_dalton
30173
uniprot
proteins
protein_family
DRAM/TMEM150 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
267
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q6UX65}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q6UX65}. Photoreceptor inner segment {ECO:0000250|UniProtKB:Q9CR48}. Apical cell membrane {ECO:0000250|UniProtKB:Q9CR48}. Note=Localized to photoreceptor inner segments and to the apical surface of retinal pigment epithelial cells. {ECO:0000250|UniProtKB:Q9CR48}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 53..73; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 87..107; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 118..138; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 160..180; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 203..223; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins