API5
entrez
8539
canonical
uniprot
Q9BZZ5
canonical
ensembl
ENSG00000166181
resolver
ensp
ENSP00000368129
resolver
ensp
ENSP00000402540
resolver
ensp
ENSP00000431391
resolver
genesymbol
API5
resolver
hgnc
HGNC:594
resolver
uniprot
B4DDR3
resolver
uniprot
B4DGR0
resolver
uniprot
B4DRJ2
resolver
uniprot
B4E283
resolver
uniprot
D3DR21
resolver
uniprot
E7ETZ6
resolver
uniprot
G3V1C3
resolver
uniprot
O15441
resolver
uniprot
Q9Y4J7
resolver
uniprot_entry
API5_HUMAN
resolver
uniprot_entry
B4DDR3_HUMAN
resolver
uniprot_sec
B4DGR0
resolver
uniprot_sec
B4DRJ2
resolver
uniprot_sec
B4E283
resolver
uniprot_sec
D3DR21
resolver
uniprot_sec
E7ETZ6
resolver
uniprot_sec
G3V1C3
resolver
uniprot_sec
O15441
resolver
uniprot_sec
Q9Y4J7
resolver
amino_acid_sequence
MPTVEELYRNYGILADATEQVGQHKDAYQVILDGVKGGTKEKRLAAQFIPKFFKHFPELADSAINAQLDLCEDEDVSIRRQAIKELPQFATGENLPRVADILTQLLQTDDSAEFNLVNNALLSIFKMDAKGTLGGLFSQILQGEDIVRERAIKFLSTKLKTLPDEVLTKEVEELILTESKKVLEDVTGEEFVLFMKILSGLKSLQTVSGRQQLVELVAEQADLEQTFNPSDPDCVDRLLQCTRQAVPLFSKNVHSTRFVTYFCEQVLPNLGTLTTPVEGLDIQLEVLKLLAEMSSFCGDMEKLETNLRKLFDKLLEYMPLPPEEAENGENAGNEEPKLQFSYVECLLYSFHQLGRKLPDFLTAKLNAEKLKDFKIRLQYFARGLQVYIRQLRLALQGKTGEALKTEENKIKVVALKITNNINVLIKDLFHIPPSYKSTVTLSWKPVQKVEIGQKRASEDTTSGSPPKKSSAGPKRDARQIYNPPSGKYSSNLGNFNYEQRGAFRGSRGGRGWGTRGNRSRGRLY
uniprot
proteins
function
FUNCTION: Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. {ECO:0000269|PubMed:10780674, ECO:0000269|PubMed:17112319, ECO:0000269|PubMed:19387494}.
uniprot
proteins
mass_dalton
59005
uniprot
proteins
post_translational_modification
PTM: Acetylation at Lys-251 impairs antiapoptotic function. {ECO:0000269|PubMed:22334682}.
uniprot
proteins
protein_family
API5 family
uniprot
proteins
pubmed
10393420
uniprot
proteins
pubmed
10780674
uniprot
proteins
pubmed
11075807
uniprot
proteins
pubmed
11557113
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17112319
uniprot
proteins
pubmed
17827341
uniprot
proteins
pubmed
19387494
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22334682
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8889549
uniprot
proteins
pubmed
9307294
uniprot
proteins
sequence_length
524
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11075807}. Cytoplasm {ECO:0000269|PubMed:11075807}. Note=Mainly nuclear. Can also be cytoplasmic.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm.
uniprot
proteins