ASB2
entrez
51676
canonical
uniprot
Q96Q27
canonical
ensembl
ENSG00000100628
resolver
ensembl
ENSG00000278693
resolver
ensp
ENSP00000320675
resolver
ensp
ENSP00000450940
resolver
ensp
ENSP00000451575
resolver
ensp
ENSP00000561259
resolver
ensp
ENSP00000561261
resolver
ensp
ENSP00000561262
resolver
ensp
ENSP00000639000
resolver
genesymbol
ASB2
resolver
hgnc
HGNC:16012
resolver
uniprot
B2RDP9
resolver
uniprot
B4E166
resolver
uniprot
Q9NSU5
resolver
uniprot
Q9Y567
resolver
uniprot_entry
ASB2_HUMAN
resolver
uniprot_sec
B2RDP9
resolver
uniprot_sec
B4E166
resolver
uniprot_sec
Q9NSU5
resolver
uniprot_sec
Q9Y567
resolver
amino_acid_sequence
MATQISTRGSQCTIGQEEYSLYSSLSEDELVQMAIEQSLADKTRGPTTAEATASACTNRQPAHFYPWTRSTAPPESSPARAPMGLFQGVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPPAPQPSSRFNDAPAADKEPSVVQFCEFVSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENTQ
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15590664, PubMed:16325183). Mediates Notch-induced ubiquitination and degradation of substrates including TCF3/E2A and JAK2 (PubMed:21119685). Required during embryonic heart development for complete heart looping (By similarity). Required for cardiomyocyte differentiation (PubMed:32179481). Specifically promotes the ubiquitination of SMAD9 and targets it for proteasomal degradation, leading to avoid excessive accumulation of SMAD9 (PubMed:34845242). Plays a role in the regulation of NK-cell migration by modulating protein levels of filamin A/FLNA via regulation of its ubiquitination and proteasome degradation (By similarity). {ECO:0000250|UniProtKB:Q8K0L0, ECO:0000269|PubMed:15590664, ECO:0000269|PubMed:16325183, ECO:0000269|PubMed:21119685, ECO:0000269|PubMed:32179481, ECO:0000269|PubMed:34845242}.; FUNCTION: [Isoform 1]: Involved in myogenic differentiation and targets filamin FLNB for proteasomal degradation but not filamin FLNA (PubMed:19300455). Also targets DES for proteasomal degradation (By similarity). Acts as a negative regulator of skeletal muscle mass (By similarity). {ECO:0000250|UniProtKB:Q8K0L0, ECO:0000269|PubMed:19300455}.; FUNCTION: [Isoform 2]: Targets filamins FLNA and FLNB for proteasomal degradation (PubMed:21737450, PubMed:22916308, PubMed:24044920, PubMed:24052262). This leads to enhanced adhesion of hematopoietic cells to fibronectin (PubMed:21737450). Required for FLNA degradation in immature cardiomyocytes which is necessary for actin cytoskeleton remodeling, leading to proper organization of myofibrils and function of mature cardiomyocytes (By similarity). Required for degradation of FLNA and FLNB in immature dendritic cells (DC) which enhances immature DC migration by promoting DC podosome formation and DC-mediated degradation of the extracellular matrix (By similarity). Does not promote proteasomal degradation of tyrosine-protein kinases JAK1 or JAK2 in hematopoietic cells (PubMed:22916308). {ECO:0000250|UniProtKB:Q8K0L0, ECO:0000269|PubMed:21737450, ECO:0000269|PubMed:22916308, ECO:0000269|PubMed:24044920, ECO:0000269|PubMed:24052262}.
uniprot
proteins
mass_dalton
70212
uniprot
proteins
mutagenesis
MUTAGEN 27..29; /note="EDE->AAA: Abolishes monoubiquitination."; /evidence="ECO:0000269|PubMed:22382022"; MUTAGEN 38; /note="S->A: Abolishes monoubiquitination."; /evidence="ECO:0000269|PubMed:22382022"; MUTAGEN 371; /note="S->A: Abolishes phosphorylation. Abolishes degradation of FLNA. No effect on assembly into ubiquitin-protein ligase complex."; /evidence="ECO:0000269|PubMed:24044920"; MUTAGEN 371; /note="S->D: Phosphomimetic mutant. No effect on isoform 2 FLNA degradation. No effect on assembly into ubiquitin-protein ligase complex."; /evidence="ECO:0000269|PubMed:24044920"; MUTAGEN 596; /note="L->P: No interaction with Elongin BC complex."; /evidence="ECO:0000269|PubMed:15590664"; MUTAGEN 599..600; /note="LC->PF: No interaction with CUL5 or RNF7."; /evidence="ECO:0000269|PubMed:16325183"; MUTAGEN 600; /note="C->P: No interaction with Elongin BC complex."; /evidence="ECO:0000269|PubMed:15590664"; MUTAGEN 619..622; /note="LPLP->AAAA: No interaction with CUL5 or RNF7."; /evidence="ECO:0000269|PubMed:16325183
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: [Isoform 1]: Monoubiquitinated. {ECO:0000269|PubMed:22382022}.; PTM: [Isoform 2]: Not monoubiquitinated. {ECO:0000269|PubMed:22382022}.; PTM: [Isoform 2]: Phosphorylation at Ser-371 is required for association with FLNA and subsequent FLNA degradation. {ECO:0000269|PubMed:24044920}.
uniprot
proteins
protein_family
Ankyrin SOCS box (ASB) family
uniprot
proteins
pubmed
11111040
uniprot
proteins
pubmed
11566180
uniprot
proteins
pubmed
11682484
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15590664
uniprot
proteins
pubmed
16325183
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19300455
uniprot
proteins
pubmed
21119685
uniprot
proteins
pubmed
21737450
uniprot
proteins
pubmed
22382022
uniprot
proteins
pubmed
22916308
uniprot
proteins
pubmed
24044920
uniprot
proteins
pubmed
24052262
uniprot
proteins
pubmed
29955039
uniprot
proteins
pubmed
32179481
uniprot
proteins
pubmed
34845242
uniprot
proteins
sequence_length
635
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:24044920}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:Q8K0L0}. Note=Localizes to the Z line in cardiomyocytes. {ECO:0000250|UniProtKB:Q8K0L0}.
uniprot
proteins