CIP2A
entrez
57650
canonical
uniprot
Q8TCG1
canonical
ensembl
ENSG00000163507
resolver
ensp
ENSP00000295746
resolver
ensp
ENSP00000754625
resolver
genesymbol
CIP2A
resolver
genesymbol_syn
KIAA1524
resolver
hgnc
HGNC:29302
resolver
uniprot
A1L4J7
resolver
uniprot
B9EGC3
resolver
uniprot
Q6P4G6
resolver
uniprot
Q8WVP8
resolver
uniprot
Q96PI2
resolver
uniprot
Q9H9C6
resolver
uniprot
Q9P204
resolver
uniprot_entry
CIP2A_HUMAN
resolver
uniprot_sec
A1L4J7
resolver
uniprot_sec
B9EGC3
resolver
uniprot_sec
Q6P4G6
resolver
uniprot_sec
Q8WVP8
resolver
uniprot_sec
Q96PI2
resolver
uniprot_sec
Q9H9C6
resolver
uniprot_sec
Q9P204
resolver
amino_acid_sequence
MDSTACLKSLLLTVSQYKAVKSEANATQLLRHLEVISGQKLTRLFTSNQILTSECLSCLVELLEDPNISASLILSIIGLLSQLAVDIETRDCLQNTYNLNSVLAGVVCRSSHTDSVFLQCIQLLQKLTYNVKIFYSGANIDELITFLIDHIQSSEDELKMPCLGLLANLCRHNLSVQTHIKTLSNVKSFYRTLITLLAHSSLTVVVFALSILSSLTLNEEVGEKLFHARNIHQTFQLIFNILINGDGTLTRKYSVDLLMDLLKNPKIADYLTRYEHFSSCLHQVLGLLNGKDPDSSSKVLELLLAFCSVTQLRHMLTQMMFEQSPPGSATLGSHTKCLEPTVALLRWLSQPLDGSENCSVLALELFKEIFEDVIDAANCSSADRFVTLLLPTILDQLQFTEQNLDEALTRKKCERIAKAIEVLLTLCGDDTLKMHIAKILTTVKCTTLIEQQFTYGKIDLGFGTKVADSELCKLAADVILKTLDLINKLKPLVPGMEVSFYKILQDPRLITPLAFALTSDNREQVQSGLRILLEAAPLPDFPALVLGESIAANNAYRQQETEHIPRKMPWQSSNHSFPTSIKCLTPHLKDGVPGLNIEELIEKLQSGMVVKDQICDVRISDIMDVYEMKLSTLASKESRLQDLLETKALALAQADRLIAQHRCQRTQAETEARTLASMLREVERKNEELSVLLKAQQVESERAQSDIEHLFQHNRKLESVAEEHEILTKSYMELLQRNESTEKKNKDLQITCDSLNKQIETVKKLNESLKEQNEKSIAQLIEKEEQRKEVQNQLVDREHKLANLHQKTKVQEEKIKTLQKEREDKEETIDILRKELSRTEQIRKELSIKASSLEVQKAQLEGRLEEKESLVKLQQEELNKHSHMIAMIHSLSGGKINPETVNLSI
uniprot
proteins
function
FUNCTION: Acts as an inhibitor of protein phosphatase PP2A (PubMed:17632056). Promotes anchorage-independent cell growth and tumor formation by preventing dephosphorylation of MYC, thereby stabilizing MYC in human malignancies (PubMed:17632056). Together with TOPBP1, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (PubMed:35121901, PubMed:35842428, PubMed:37165191, PubMed:37316668). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (PubMed:37165191, PubMed:37316668). {ECO:0000269|PubMed:17632056, ECO:0000269|PubMed:35121901, ECO:0000269|PubMed:35842428, ECO:0000269|PubMed:37165191, ECO:0000269|PubMed:37316668}.
uniprot
proteins
mass_dalton
102185
uniprot
proteins
mutagenesis
MUTAGEN 230; /note="N->E: Reduces binding to PPP2R5C."; /evidence="ECO:0000269|PubMed:28174209"; MUTAGEN 522; /note="R->D: Decreases homodimerization. Reduces binding to PPP2R5C. Decreases protein level."; /evidence="ECO:0000269|PubMed:28174209"; MUTAGEN 533; /note="L->E: Decreases homodimerization. Reduces binding to PPP2R5C. Decreases protein level."; /evidence="ECO:0000269|PubMed:28174209
uniprot
proteins
protein_family
CIP2A family
uniprot
proteins
pubmed
10819331
uniprot
proteins
pubmed
12118381
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15538718
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17632056
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28174209
uniprot
proteins
pubmed
35121901
uniprot
proteins
pubmed
35842428
uniprot
proteins
pubmed
37165191
uniprot
proteins
pubmed
37316668
uniprot
proteins
sequence_length
905
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12118381, ECO:0000269|PubMed:35842428}. Chromosome {ECO:0000269|PubMed:35121901, ECO:0000269|PubMed:35842428, ECO:0000269|PubMed:37165191, ECO:0000269|PubMed:37316668}. Note=Predominantly localizes within the cytoplasm (PubMed:35842428). Localizes to broken chromosomes within micronuclei during interphase and following chromothripsis (PubMed:37165191, PubMed:37316668). Localization to broken chromosomes is mainly independent of MDC1 (PubMed:35121901, PubMed:37165191). {ECO:0000269|PubMed:35121901, ECO:0000269|PubMed:35842428, ECO:0000269|PubMed:37165191, ECO:0000269|PubMed:37316668}.
uniprot
proteins