TMEM30B
entrez
161291
canonical
uniprot
Q3MIR4
canonical
ensembl
ENSG00000182107
resolver
ensp
ENSP00000450842
resolver
enst
ENST00000555868
resolver
genesymbol
TMEM30B
resolver
genesymbol_syn
CDC50B
resolver
hgnc
HGNC:27254
resolver
uniprot
B3KR84
resolver
uniprot
Q14D00
resolver
uniprot_entry
CC50B_HUMAN
resolver
uniprot_sec
B3KR84
resolver
uniprot_sec
Q14D00
resolver
amino_acid_sequence
MTWSATARGAHQPDNTAFTQQRLPAWQPLLSASIALPLFFCAGLAFIGLGLGLYYSSNGIKELEYDYTGDPGTGNCSVCAAAGQGRALPPPCSCAWYFSLPELFQGPVYLYYELTNFYQNNRRYGVSRDDAQLSGLPSALRHPVNECAPYQRSAAGLPIAPCGAIANSLFNDSFSLWHQRQPGGPYVEVPLDRSGIAWWTDYHVKFRNPPLVNGSLALAFQGTAPPPNWRRPVYELSPDPNNTGFINQDFVVWMRTAALPTFRKLYARIRQGNYSAGLPRGAYRVNITYNYPVRAFGGHKLLIFSSISWMGGKNPFLGIAYLVVGSLCILTGFVMLVVYIRYQDQDDDDEE
uniprot
proteins
function
FUNCTION: Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate (Probable). Can mediate the export of alpha subunits ATP8A1, ATP8B1, ATP8B2 and ATP8B4 from the ER to the plasma membrane. {ECO:0000269|PubMed:20961850, ECO:0000305}.
uniprot
proteins
mass_dalton
38941
uniprot
proteins
protein_family
CDC50/LEM3 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15375526
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20947505
uniprot
proteins
pubmed
20961850
uniprot
proteins
pubmed
21914794
uniprot
proteins
pubmed
37293153
uniprot
proteins
sequence_length
351
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20961850}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:37293153}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..54; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 316..336; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins