SYCP1
entrez
6847
canonical
uniprot
Q15431
canonical
ensembl
ENSG00000198765
resolver
ensp
ENSP00000358531
resolver
ensp
ENSP00000358535
resolver
ensp
ENSP00000410011
resolver
ensp
ENSP00000480997
resolver
ensp
ENSP00000482532
resolver
enst
ENST00000369518
resolver
enst
ENST00000369522
resolver
enst
ENST00000613524
resolver
enst
ENST00000618516
resolver
genesymbol
SYCP1
resolver
genesymbol_syn
SCP1
resolver
hgnc
HGNC:11487
resolver
uniprot
A0A024R0I2
resolver
uniprot
A0A087WZC3
resolver
uniprot
A0A140VJW4
resolver
uniprot
B7ZLS9
resolver
uniprot
O14963
resolver
uniprot
Q5VXJ6
resolver
uniprot_entry
A0A024R0I2_HUMAN
resolver
uniprot_entry
A0A087WZC3_HUMAN
resolver
uniprot_entry
B7ZLS9_HUMAN
resolver
uniprot_entry
SYCP1_HUMAN
resolver
uniprot_sec
A0A140VJW4
resolver
uniprot_sec
O14963
resolver
uniprot_sec
Q5VXJ6
resolver
amino_acid_sequence
MEKQKPFALFVPPRSSSSQVSAVKPQTLGGDSTFFKSFNKCTEDDFEFPFAKTNLSKNGENIDSDPALQKVNFLPVLEQVGNSDCHYQEGLKDSDLENSEGLSRVYSKLYKEAEKIKKWKVSTEAELRQKESKLQENRKIIEAQRKAIQELQFGNEKVSLKLEEGIQENKDLIKENNATRHLCNLLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMITAFEELRVQAENSRLEMHFKLKEDYEKIQHLEQEYKKEINDKEKQVSLLLIQITEKENKMKDLTFLLEESRDKVNQLEEKTKLQSENLKQSIEKQHHLTKELEDIKVSLQRSVSTQKALEEDLQIATKTICQLTEEKETQMEESNKARAAHSFVVTEFETTVCSLEELLRTEQQRLEKNEDQLKILTMELQKKSSELEEMTKLTNNKEVELEELKKVLGEKETLLYENKQFEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDLKTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQEERMLKQIENLQETETQLRNELEYVREELKQKRDEVKCKLDKSEENCNNLRKQVENKNKYIEELQQENKALKKKGTAESKQLNVYEIKVNKLELELESAKQKFGEITDTYQKEIEDKKISEENLLEEVEKAKVIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEERDSELGLYKSKEQEQSSLRASLEIELSNLKAELLSVKKQLEIEREEKEKLKREAKENTATLKEKKDKKTQTFLLETPEIYWKLDSKAVPSQTVSRNFTSVDHGISKDKRDYLWTSAKNTLSTPLPKAYTVKTPTKPKLQQRENLNIPIEESKKKRKMAFEFDINSDSSETTDLLSMVSEEETLKTLYRNNNPPASHLCVKTPKKAPSSLTTPGSTLKFGAIRKMREDRWAVIAKMDRKKKLKEAEKLFV
uniprot
proteins
function
FUNCTION: Major component of the transverse filaments of synaptonemal complexes, formed between homologous chromosomes during meiotic prophase. Required for normal assembly of the central element of the synaptonemal complexes. Required for normal centromere pairing during meiosis. Required for normal meiotic chromosome synapsis during oocyte and spermatocyte development and for normal male and female fertility. {ECO:0000250|UniProtKB:Q62209}.
uniprot
proteins
mass_dalton
114192
uniprot
proteins
mutagenesis
MUTAGEN 101..111; /note="Missing: Impairs self-assembly of N-terminal ends."; /evidence="ECO:0000269|PubMed:29915389"; MUTAGEN 105; /note="V->E: Impairs self-assembly of N-terminal ends; when associated with E-109. Abolishes the formation of higher-order heterooligomers with SYCE3; when associated with E-109."; /evidence="ECO:0000269|PubMed:29915389, ECO:0000269|PubMed:36635604"; MUTAGEN 109; /note="L->E: Impairs self-assembly of N-terminal ends; when associated with E-105. Abolishes the formation of higher-order heterooligomers with SYCE3; when associated with E-105."; /evidence="ECO:0000269|PubMed:29915389, ECO:0000269|PubMed:36635604"; MUTAGEN 679; /note="L->A: Impairs pH-induced C-terminal tetrameric self-assembly; when associated with A-688."; /evidence="ECO:0000269|PubMed:29915389"; MUTAGEN 688; /note="I->A: Impairs pH-induced C-terminal tetrameric self-assembly; when associated with A-679."; /evidence="ECO:0000269|PubMed:29915389"; MUTAGEN 717; /note="H->E: Impairs pH-induced C-terminal tetrameric self-assembly."; /evidence="ECO:0000269|PubMed:29915389"; MUTAGEN 717; /note="H->W: Enables C-terminal tetrameric self-assembly at pH 8.0; when associated with F-721."; /evidence="ECO:0000269|PubMed:29915389"; MUTAGEN 721; /note="Y->F: Enables C-terminal tetrameric self-assembly at pH 8.0; when associated with W-717."; /evidence="ECO:0000269|PubMed:29915389
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
26323297
uniprot
proteins
pubmed
29915389
uniprot
proteins
pubmed
36635604
uniprot
proteins
pubmed
9119375
uniprot
proteins
pubmed
9371398
uniprot
proteins
sequence_length
976
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q62209}. Chromosome {ECO:0000250|UniProtKB:Q62209}. Chromosome, centromere {ECO:0000250|UniProtKB:Q62209}. Note=In tripartite segments of synaptonemal complexes, between lateral elements in the nucleus. Its N-terminus is found towards the center of the synaptonemal complex while the C-terminus extends well into the lateral domain of the synaptonemal complex (By similarity). Only rarely detected at centromeres during leptotene and zygotene. Detected at centromeres during mid-diplotene, when it is no longer present along chromosome arms. No longer detected at centromeres at later stages of meiosis (By similarity). {ECO:0000250|UniProtKB:Q03410, ECO:0000250|UniProtKB:Q62209}.
uniprot
proteins