Tsg101
entrez
292925
canonical
uniprot
Q6IRE4
canonical
ensembl
ENSRNOG00000013381
resolver
ensp
ENSRNOP00000018194
resolver
genesymbol
Tsg101
resolver
uniprot
Q7TSE5
resolver
uniprot_entry
TS101_RAT
resolver
uniprot_sec
Q7TSE5
resolver
amino_acid_sequence
MAVSESQLKKMMSKYKYRDLTVRQTVNVIAMYKDLKPVLDSYVFNDGSSRELVNLTGTIPVRYRGNIYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHDWKHPRSELLELIQIMIVIFGEEPPVFSRPTVSASYPPYTAAGPPNTSYLPSMPSGISAYPSGYPPNPSGYPGCPYPPAGPYPATTSSQYPSQPPVTTAGPSRDGTISEDTIRASLISAVSDKLRWRMKEEMDGAQAELNALKRTEEDLKKGHQKLEEMVTRLDQEVAEVDKNIELLKKKDEELSSALEKMENQSENNDIDEVIIPTAPLYKQILNLYAEENAIEDTIFYLGEALRRGVIDLDVFLKHVRLLSRKQFQLRALMQKARKTAGLSDLY
uniprot
proteins
function
FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Required for the exosomal release of SDCBP, CD63 and syndecan (By similarity). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (By similarity). {ECO:0000250|UniProtKB:Q99816}.
uniprot
proteins
mass_dalton
44078
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated at multiple sites by LRSAM1 and by MGRN1. Ubiquitination inactivates it, possibly by regulating its shuttling between an active membrane-bound protein and an inactive soluble form. Ubiquitination by MGRN1 requires the presence of UBE2D1. {ECO:0000250|UniProtKB:Q99816}.
uniprot
proteins
protein_family
UEV subfamily
uniprot
proteins
protein_family
Ubiquitin-conjugating enzyme family
uniprot
proteins
pubmed
14761944
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
391
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99816}. Early endosome membrane {ECO:0000250|UniProtKB:Q99816}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q99816}; Cytoplasmic side {ECO:0000250|UniProtKB:Q99816}. Late endosome membrane {ECO:0000250|UniProtKB:Q99816}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q99816}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q99816}. Midbody, Midbody ring {ECO:0000250|UniProtKB:Q99816}. Nucleus {ECO:0000250|UniProtKB:Q99816}. Note=Mainly cytoplasmic. Membrane-associated when active and soluble when inactive. Nuclear localization is cell cycle-dependent. Interaction with CEP55 is required for localization to the midbody during cytokinesis. {ECO:0000250|UniProtKB:Q99816}.
uniprot
proteins