Slc46a2
entrez
30936
canonical
uniprot
Q8CA03
canonical
ensembl
ENSMUSG00000028386
resolver
ensp
ENSMUSP00000030081
resolver
enst
ENSMUST00000030081
resolver
genesymbol
Slc46a2
resolver
genesymbol_syn
Tscot
resolver
uniprot
A2ANT4
resolver
uniprot
Q9D3J2
resolver
uniprot
Q9JLQ3
resolver
uniprot_entry
S46A2_MOUSE
resolver
uniprot_sec
A2ANT4
resolver
uniprot_sec
Q9D3J2
resolver
uniprot_sec
Q9JLQ3
resolver
activity_regulation
ACTIVITY REGULATION: Down-regulated by the anti-inflammatory drug methotrexate. {ECO:0000269|PubMed:37116499}.
uniprot
proteins
amino_acid_sequence
MGPGGTCPWSSRLSGFRVRTWIEPVVASTQVAGSLYDAGLLLVVKESFKSEAGGSSNYSANQSLVEYQEDQQQKAISNFNIIYNLVLGLTPLLSAYGLGWLSDRYHRKISICTAMLGFLLSRIGLLLKVMLDWPVEVMYGAAALNGLCGSFSAYWSGVMALGSLGCSEGRRSVRLILIDLVLGLAGFSGSMASGHLFKQIVGHSAQGLLLTACSVGCAAFALFYSLFVLKVPESKPNKVHPTVDTVSGMMGTYRTLDPDQQDKQNVPRNPRTPGKGKSSQREVVALLFVGAIIYDLAAVGTVDVMALFVLKEPLHWNQVQLGYGMASGYIIFITSFLGVLVFSRCFRDTTMIIIGMLSFGSGALLLAFVKETYMFYIARAIMLFALIPITTIRSAMSKLIKDSSYGKIFVILQLCLTLTGVVTSTIYNKIYQLTLDKFIGTCFVLSSFLSFLAIVPIGVVAYKQVPRSQQGECAEKQRS
uniprot
proteins
function
FUNCTION: Proton-coupled transporter that delivers pathogen-associated or danger-associated molecular patterns to cytosolic pattern recognition receptors as part of the innate immune response to microbes or tissue injury (PubMed:28539433, PubMed:34235268, PubMed:37116499). Has selectivity toward muropeptides that contain the amino acid diaminopimelic acid (DAP-type peptidoglycan muropeptides) including Tri-DAP and tracheal toxin (TCT), common in Gram-negative bacteria and Gram-positive bacilli. In the context of immune recognition of skin microbiota, shuttles bacterial muropeptides across the endolysosomal membranes into the cytosol for recognition by NOD1, triggering MYD88-dependent secretion of IL1A and neutrophil recruitment in a pyroptosis-type inflammatory process (PubMed:28539433, PubMed:37116499). To a lesser extent and redundantly, transports muramyl dipeptides derived from most bacterial proteoglycans, eliciting NOD2 receptor activation and downstream inflammatory responses (PubMed:28539433). Postulated to function as an importer of cyclic GMP-AMP dinucleotides (cGAMPs) in monocyte and macrophage cell lineages. Selectively imports cGAMPs derived from pathogenic bacteria such as 3'3'-cGAMP thus providing for differential immune recognition of pathogenic versus commensal bacteria. During tumorigenesis may transport extracellular tumor-derived 2'3'-cGAMP across the plasma membrane of M1-polarized macrophages to activate the anti-tumoral stimulator of interferon genes (STING) pathway (PubMed:34235268). The transport mechanism, its electrogenicity and stoichiometry remain to be elucidated (Probable). {ECO:0000269|PubMed:28539433, ECO:0000269|PubMed:34235268, ECO:0000269|PubMed:37116499, ECO:0000305}.
uniprot
proteins
mass_dalton
52083
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:10706709}.
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
SLC46A family
uniprot
proteins
pubmed
10706709
uniprot
proteins
pubmed
10978518
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
28539433
uniprot
proteins
pubmed
34235268
uniprot
proteins
pubmed
37116499
uniprot
proteins
sequence_length
479
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:28539433}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9BY10}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9BY10}. Note=Localizes in acidic vesicles likely late endosomes and/or endolysosomes. {ECO:0000269|PubMed:28539433}.
uniprot
proteins
transmembrane_region
TRANSMEM 24..44; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 81..101; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 111..131; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 141..161; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 175..195; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 208..228; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 282..302; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 322..342; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 349..369; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 372..392; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 408..428; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 442..462; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins