ATOX1
entrez
475
canonical
uniprot
O00244
canonical
ensembl
ENSG00000177556
resolver
ensp
ENSP00000316854
resolver
ensp
ENSP00000429814
resolver
ensp
ENSP00000430598
resolver
ensp
ENSP00000527665
resolver
ensp
ENSP00000584500
resolver
enst
ENST00000313115
resolver
enst
ENST00000522710
resolver
enst
ENST00000524142
resolver
enst
ENST00000857606
resolver
enst
ENST00000914441
resolver
genesymbol
ATOX1
resolver
genesymbol_syn
HAH1
resolver
hgnc
HGNC:798
resolver
uniprot
A8KAJ8
resolver
uniprot
D3DQI2
resolver
uniprot
Q2M1R6
resolver
uniprot
Q56AP3
resolver
uniprot_entry
ATOX1_HUMAN
resolver
uniprot_sec
A8KAJ8
resolver
uniprot_sec
D3DQI2
resolver
uniprot_sec
Q2M1R6
resolver
uniprot_sec
Q56AP3
resolver
amino_acid_sequence
MPKHEFSVDMTCGGCAEAVSRVLNKLGGVKYDIDLPNKKVCIESEHSMDTLLATLKKTGKTVSYLGLE
uniprot
proteins
function
FUNCTION: Multifunctional copper-sensing protein that operates both as a cytosolic copper chaperone and as a copper-dependent transcription factor. Essential for maintaining cellular copper homeostasis and linking copper distribution to redox balance, signal transduction, and gene regulation. In the cytosol, transfers copper to the copper-transporting ATPase ATP7A at the trans-Golgi network, which is required for activation of secretory copper enzymes including lysyl oxidase (LOX) and SOD3. This chaperone function is essential for full SOD3 and LOX enzymatic activity. Acts as a copper-dependent transcription factor. Upon copper binding, translocates to the nucleus where it binds specific promoter elements and regulates transcription of genes involved in cell proliferation, oxidative stress defense, and extracellular matrix remodeling. Activates expression of target genes including CCND1, SOD3 and NCF1, thereby linking cellular copper status to gene expression programs controlling growth and redox homeostasis. {ECO:0000250|UniProtKB:O08997}.
uniprot
proteins
mass_dalton
7402
uniprot
proteins
mutagenesis
MUTAGEN 15; /note="C->A: Impairs Cu(+)-bridged heterodimer formation with ATP7A."; /evidence="ECO:0000269|PubMed:31283225"; MUTAGEN 21; /note="R->E: Has no overall effect on Cu(+)-bridged heterodimer formation with ATP7A."; /evidence="ECO:0000269|PubMed:19453293"; MUTAGEN 22; /note="V->A: Has no overall effect on Cu(+)-bridged heterodimer formation with ATP7A."; /evidence="ECO:0000269|PubMed:19453293"; MUTAGEN 58; /note="T->A: Has no overall effect on Cu(+)-bridged heterodimer formation with ATP7A."; /evidence="ECO:0000269|PubMed:19453293
uniprot
proteins
protein_family
ATX1 family
uniprot
proteins
pubmed
10966647
uniprot
proteins
pubmed
12594858
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19453293
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21667063
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24837030
uniprot
proteins
pubmed
26745413
uniprot
proteins
pubmed
31283225
uniprot
proteins
pubmed
9083055
uniprot
proteins
sequence_length
68
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O08997}. Nucleus {ECO:0000250|UniProtKB:O08997}. Note=Primarily cytoplasmic; translocates to the nucleus in a copper- and stimulus-dependent manner. {ECO:0000250|UniProtKB:O08997}.
uniprot
proteins