Rnaseh2a
entrez
69724
canonical
uniprot
Q9CWY8
canonical
ensembl
ENSMUSG00000052926
resolver
ensp
ENSMUSP00000066769
resolver
ensp
ENSMUSP00000105358
resolver
ensp
ENSMUSP00000105360
resolver
ensp
ENSMUSP00000120374
resolver
enst
ENSMUST00000065049
resolver
enst
ENSMUST00000109736
resolver
enst
ENSMUST00000109738
resolver
enst
ENSMUST00000147812
resolver
genesymbol
Rnaseh2a
resolver
genesymbol_syn
Rnasehi
resolver
uniprot
F8WGL0
resolver
uniprot
Q05C51
resolver
uniprot
Q8CHY8
resolver
uniprot_entry
F8WGL0_MOUSE
resolver
uniprot_entry
Q05C51_MOUSE
resolver
uniprot_entry
RNH2A_MOUSE
resolver
uniprot_sec
Q8CHY8
resolver
amino_acid_sequence
MDLSELERDNTGRCRLSSPVPAVCLKEPCVLGVDEAGRGPVLGPMVYAICYCPLSRLADLEALKVADSKTLTENERERLFAKMEEDGDFVGWALDVLSPNLISTSMLGRVKYNLNSLSHDTAAGLIQYALDQNVNVTQVFVDTVGMPETYQARLQQHFPGIEVTVKAKADSLFPVVSAASIFAKVARDKAVKNWQFVENLQDLDSDYGSGYPNDPKTKAWLRKHVDPVFGFPQFVRFSWSTAQAILEKEAEDVIWEDSEAEEDPERPGKITSYFSQGPQTCRPQAPHRYFQERGLEAASSL
uniprot
proteins
ec_number
3.1.26.4
uniprot
proteins
function
FUNCTION: Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes. {ECO:0000269|PubMed:19923215}.
uniprot
proteins
mass_dalton
33513
uniprot
proteins
mutagenesis
MUTAGEN 34; /note="D->N: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:19923215"; MUTAGEN 35; /note="E->A: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:19923215"; MUTAGEN 37; /note="G->S: Strongly reduced in vitro enzyme activity."; /evidence="ECO:0000269|PubMed:19923215"; MUTAGEN 142; /note="D->N: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:19923215"; MUTAGEN 170; /note="D->N: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:19923215
uniprot
proteins
protein_family
Eukaryotic subfamily
uniprot
proteins
protein_family
RNase HII family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19923215
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
301
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins