Msl1
entrez
74026
canonical
uniprot
Q6PDM1
canonical
ensembl
ENSMUSG00000052915
resolver
ensp
ENSMUSP00000042792
resolver
ensp
ENSMUSP00000043328
resolver
ensp
ENSMUSP00000103109
resolver
ensp
ENSMUSP00000103111
resolver
genesymbol
Msl1
resolver
genesymbol_syn
Msl1l1
resolver
uniprot
A3KFP2
resolver
uniprot
A3KFP4
resolver
uniprot
Q27QB3
resolver
uniprot
Q3TTE5
resolver
uniprot
Q80XS0
resolver
uniprot
Q8BPN3
resolver
uniprot
Q9CXF9
resolver
uniprot
Q9D5C9
resolver
uniprot_entry
MSL1_MOUSE
resolver
uniprot_sec
A3KFP2
resolver
uniprot_sec
A3KFP4
resolver
uniprot_sec
Q27QB3
resolver
uniprot_sec
Q3TTE5
resolver
uniprot_sec
Q80XS0
resolver
uniprot_sec
Q8BPN3
resolver
uniprot_sec
Q9CXF9
resolver
uniprot_sec
Q9D5C9
resolver
amino_acid_sequence
MTMRSAVFKAAAAPAGGNPEQRLDYERAAALGGPEDESGAAEAHFLPRHRKLKEPGPPLASSQGGSPSPSPAGCGGGKGRGLLLPAGAAPGQQEESWGGSVPLPCPPPATKQAGIGGEPVAAGAGCSPRPKYQAVLPIQTGSIVVAAAKEPTPWAGDKGGAAPPAATASDPAGPPPLPLPGPPPLAPTATAGTLAASEGRWKSIRKSPLGGGGGSGASSQAACLKQILLLQLDLIEQQQQQLQAKEKEIEELKSERDTLLARIERMERRMQLVKRDNEKERHKLLQGYEPEEREEAELSEKIKLERQPELCETSQALPSKPFSCGRSGKGHKRKTPFGNTERKTPVKKLAPEFSKVKTKTPKHSPIKEEPCGSISETVCKRELRSQETPEKPRSSVDTPPRLSTPQKGPSTHPKEKAFSSEMEDLPYLSTTEMYLCRWHQPPPSPLPLRESSPKKEETVARCLMPSSVAGETSVLAVPSWRDHSVEPLRDPNPSDILENLDDSVFSKRHAKLELDEKRRKRWDIQRIREQRILQRLQLRMYKKKGIQESEPEVTSFFPEPDDVESLLITPFLPVVAFGRPLPKLAPQNFELPWLDERSRCRLEIQKKHTPHRTCRK
uniprot
proteins
function
FUNCTION: Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:21217699, PubMed:23523075, PubMed:24842875, PubMed:24913909). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (By similarity). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (PubMed:23523075). X up-regulation is required to compensate for autosomal biallelic expression (PubMed:23523075). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (PubMed:24842875). Within the MSL complex, acts as a scaffold to tether MSL3 and KAT8 together for enzymatic activity regulation (PubMed:21217699). Greatly enhances MSL2 E3 ubiquitin ligase activity, promoting monoubiquitination of histone H2B at 'Lys-34' (H2BK34Ub) (By similarity). This modification in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (By similarity). {ECO:0000250|UniProtKB:Q68DK7, ECO:0000269|PubMed:21217699, ECO:0000269|PubMed:23523075, ECO:0000269|PubMed:24842875, ECO:0000269|PubMed:24913909}.
uniprot
proteins
mass_dalton
67320
uniprot
proteins
mutagenesis
MUTAGEN 498; /note="E->R: Abolishes interaction with KAT8."; /evidence="ECO:0000269|PubMed:21217699"; MUTAGEN 505; /note="F->R: Abolishes interaction with KAT8."; /evidence="ECO:0000269|PubMed:21217699"; MUTAGEN 509; /note="H->R: Abolishes interaction with KAT8."; /evidence="ECO:0000269|PubMed:21217699"; MUTAGEN 556; /note="F->E: Strongly reduces interaction with MSL3; when associated with E-576 and E-589 or E-577 and E-589."; /evidence="ECO:0000269|PubMed:21217699"; MUTAGEN 576; /note="A->E: No effect on interaction with MSL3. Reduces interaction; when associated with E-589. Strongly reduces interaction with MSL3; when associated with E-556 and E-589."; /evidence="ECO:0000269|PubMed:21217699"; MUTAGEN 577; /note="F->E: No effect on interaction with MSL3. Reduces interaction; when associated with E-589. Strongly reduces interaction with MSL3; when associated with E-556 and E-589."; /evidence="ECO:0000269|PubMed:21217699"; MUTAGEN 589; /note="F->E: Strongly reduces interaction with MSL3; when associated with E-556 and E-576 or E-556 and E-577."; /evidence="ECO:0000269|PubMed:21217699
uniprot
proteins
post_translational_modification
PTM: Sumoylated with SUMO1. {ECO:0000250|UniProtKB:Q68DK7}.
uniprot
proteins
protein_family
Msl-1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16119455
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17335777
uniprot
proteins
pubmed
19390865
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21217699
uniprot
proteins
pubmed
23523075
uniprot
proteins
pubmed
24842875
uniprot
proteins
pubmed
24898753
uniprot
proteins
pubmed
24913909
uniprot
proteins
pubmed
27183194
uniprot
proteins
sequence_length
616
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17335777, ECO:0000269|PubMed:24913909}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:24913909}. Nucleus speckle {ECO:0000269|PubMed:24913909}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:19390865, ECO:0000269|PubMed:24913909}. Nucleus speckle {ECO:0000269|PubMed:24913909}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus {ECO:0000269|PubMed:16119455}. Nucleus, nucleoplasm {ECO:0000269|PubMed:24913909}.; SUBCELLULAR LOCATION: [Isoform 4]: Nucleus, nucleoplasm {ECO:0000269|PubMed:24913909}.; SUBCELLULAR LOCATION: [Isoform 5]: Nucleus, nucleoplasm {ECO:0000269|PubMed:24913909}.
uniprot
proteins