Inpp4b
entrez
234515
canonical
uniprot
Q6P1Y8
canonical
ensembl
ENSMUSG00000037940
resolver
ensp
ENSMUSP00000044466
resolver
ensp
ENSMUSP00000105477
resolver
ensp
ENSMUSP00000105478
resolver
ensp
ENSMUSP00000131324
resolver
ensp
ENSMUSP00000131947
resolver
ensp
ENSMUSP00000132156
resolver
ensp
ENSMUSP00000148972
resolver
ensp
ENSMUSP00000150520
resolver
ensp
ENSMUSP00000150541
resolver
ensp
ENSMUSP00000299843
resolver
ensp
ENSMUSP00000299847
resolver
enst
ENSMUST00000042529
resolver
enst
ENSMUST00000109852
resolver
enst
ENSMUST00000169116
resolver
enst
ENSMUST00000172031
resolver
enst
ENSMUST00000213285
resolver
enst
ENSMUST00000215332
resolver
enst
ENSMUST00000217122
resolver
genesymbol
Inpp4b
resolver
uniprot
A0A1L1STW8
resolver
uniprot
E9PVM1
resolver
uniprot
E9PVM3
resolver
uniprot
Q1A6U9
resolver
uniprot
Q1A6V0
resolver
uniprot
Q1A6V1
resolver
uniprot
Q3URI3
resolver
uniprot_entry
A0A1L1STW8_MOUSE
resolver
uniprot_entry
E9PVM1_MOUSE
resolver
uniprot_entry
E9PVM3_MOUSE
resolver
uniprot_entry
INP4B_MOUSE
resolver
uniprot_entry
Q3URI3_MOUSE
resolver
uniprot_sec
Q1A6U9
resolver
uniprot_sec
Q1A6V0
resolver
uniprot_sec
Q1A6V1
resolver
activity_regulation
ACTIVITY REGULATION: Strongly inhibited by inositol hexakisphosphate. {ECO:0000250|UniProtKB:Q9QWG5}.
uniprot
proteins
amino_acid_sequence
MEIKEEGTSEEGQHFLPAAQANDPEDIQFTSIQKIPNEPQLEFILACRDLVAPVSDRKLNTVVQISVIHPVEQTLTRYSSTEIVEGTKDPLFLTGVTFPPDYPIYEETRIKLTVYDVKDKSHDTIRTSVLPEHKDPLPEVARSFLGCASFKVGELLKSKEQLLSLSLRTSDGGKVVGTIEVSLVKMGEIEDGDTDHITTDVQGQKCALMYESTAPESLSGKENLPFMNAVLRNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQELKELGDLSPHWDNLRKNVLSHCDQMVTMYQDILTELSKETGSSFKSSSSKGEKTLEFVPVNLHLQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTGYQFIYYSPENTAKAKEVLSSINQLQPLIATHADLLLTSASQRSPDSLKSSLKLLSEKTELFVHAFKDQLVRSALLALYTARPGGILKKPPSPNVSTEEKSTQHDTPQLRRQDSIPHHSDYDEEEWDRVWANVGKSLNCIIAKVDKLIERDSHNEEGAGGSSSKDGEADHTLEDSITSHPREDWYEQLHPLILTLKECMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLHTSLHDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAVGISDLRKVAFKITEATSNDVLPVLTGRREHYVVEVKLPATVFESLPLQIKEGQLLHVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELVQEYYSIFMEKMPPDYISHFQEQTDLKGLLDNLHQNIQAKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRREGCRIENVLKNIKCRRYAFNMLQLMAFPKCYRPPEGTYGKADT
uniprot
proteins
ec_number
3.1.3.66
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-bisphosphate (By similarity). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (By similarity). Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (By similarity). {ECO:0000250|UniProtKB:O15327, ECO:0000250|UniProtKB:Q9QWG5}.
uniprot
proteins
mass_dalton
105160
uniprot
proteins
pathway_participation
PATHWAY: Signal transduction; phosphatidylinositol signaling pathway. {ECO:0000250|UniProtKB:Q9QWG5}.
uniprot
proteins
protein_family
4-bisphosphate 4-phosphatase family
uniprot
proteins
protein_family
Inositol 3
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16631325
uniprot
proteins
sequence_length
927
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:16631325}.; SUBCELLULAR LOCATION: [Isoform 3]: Golgi apparatus {ECO:0000269|PubMed:16631325}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000269|PubMed:16631325}.
uniprot
proteins