Eif3e
entrez
16341
canonical
uniprot
P60229
canonical
ensembl
ENSMUSG00000022336
resolver
ensp
ENSMUSP00000022960
resolver
enst
ENSMUST00000022960
resolver
genesymbol
Eif3e
resolver
genesymbol_syn
EIF3E
resolver
genesymbol_syn
EIF3S6
resolver
genesymbol_syn
Eif3s6
resolver
genesymbol_syn
INT6
resolver
genesymbol_syn
Int6
resolver
uniprot
O43902
resolver
uniprot
Q3UIG0
resolver
uniprot
Q64058
resolver
uniprot
Q64059
resolver
uniprot
Q64252
resolver
uniprot_entry
EIF3E_MOUSE
resolver
uniprot_entry
Q3UIG0_MOUSE
resolver
uniprot_sec
O43902
resolver
uniprot_sec
Q64058
resolver
uniprot_sec
Q64059
resolver
uniprot_sec
Q64252
resolver
amino_acid_sequence
MAEYDLTTRIAHFLDRHLVFPLLEFLSVKEIYNEKELLQGKLDLLSDTNMVDFAMDVYKNLYSDDIPHALREKRTTVVAQLKQLQAETEPIVKMFEDPETTRQMQSTRDGRMLFDYLADKHGFRQEYLDTLYRYAKFQYECGNYSGAAEYLYFFRVLVPATDRNALSSLWGKLASEILMQNWDAAMEDLTRLKETIDNNSVSSPLQSLQQRTWLIHWSLFVFFNHPKGRDNIIDLFLYQPQYLNAIQTMCPHILRYLTTAVITNKDVRKRRQVLKDLVKVIQQESYTYKDPITEFVECLYVNFDFDGAQKKLRECESVLVNDFFLVACLEDFIENARLFIFETFCRIHQCISINMLADKLNMTPEEAERWIVNLIRNARLDAKIDSKLGHVVMGNNAVSPYQQVIEKTKSLSFRSQMLAMNIEKKLNQNSRSEAPNWATQDSGFY
uniprot
proteins
disease_involvement
DISEASE: Note=EIF3E serves as a site for viral integration of mouse mammary tumor virus (MMTV) in mammary tumors. MMTV integration into EIF3E can result in EIF3E truncation and expression of chimeric RNA species which terminate at a cryptic transcription stop signal in the reverse U3 portion of the MMTV long terminal repeat. This causes deregulation of the normal control of mammary epithelial cell growth. {ECO:0000269|PubMed:7853537}.
uniprot
proteins
function
FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins. {ECO:0000255|HAMAP-Rule:MF_03004, ECO:0000269|PubMed:17581632}.
uniprot
proteins
mass_dalton
52221
uniprot
proteins
protein_family
EIF-3 subunit E family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
17581632
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7853537
uniprot
proteins
pubmed
9260927
uniprot
proteins
sequence_length
445
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03004}. Nucleus, PML body {ECO:0000255|HAMAP-Rule:MF_03004}.
uniprot
proteins