Smarcad1
entrez
312398
canonical
uniprot
D3Z9Z9
canonical
ensembl
ENSRNOG00000006391
resolver
ensp
ENSRNOP00000008585
resolver
enst
ENSRNOT00000008585
resolver
genesymbol
Smarcad1
resolver
uniprot_entry
SMRCD_RAT
resolver
amino_acid_sequence
MNLFNLDRFRFEKRSKIEEAPEAAPQPSQPGPSSPISLSAEEENAEGEVSRANTPDSDVTEKTEDSSVPEPPDNESKASLSCFQNQRTIQEYIDLSSDSEDVSPNCSSTVQEKKFSKDTVIIVSEPSEDEESHDLPSATRRNDISELEDLSELEDLKDAKLQTLKELFPQRSDSDLLKLIDSTSTMDGAIAAALLKFGDAGGGPRKRKLSSSSEAYEEDEANDDQSLKKPRGDRREESNESAEASSNWEKQESIVLKLQKEFPNFDKQELREVLKEHEWMYTEALESLKVFAEDQDVQCASQSEVTNGKEVARNQNYSKNAAKIKMKQKISMKPQNGFNKKRKKNVFNPKKAVEDSEYDSGSDAGSSLDEDYSSCEEVMEDGYKGKILHFLQDASIGELTLIPKCSQKKAQKIIELRPFNNWETLFTKMSKINGLSEDLIWNCKTVIQERDVVIRLMNKCEDISNKLTKQVTMLTGNGGGWNIEQPSLLNQSLSLKPYQKVGLNWLALVHKHGLNGILADEMGLGKTIQAIAFLAYLFQEGNKGPHLIVVPASTIDNWLREVNLWCPTLNVLCYYGSQEERKQIRFNIHNKYEDYNVIVTTYNCAISSSDDRSLFRRLKLNYAIFDEGHMLKNMGSIRYQHLMTINARNRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTKPADEQSIYEKERIAHAKQIIKPFILRRVKEEVLKLLPPKKDQIELCAMSEKQEQLYSGLFNRLKKSINNLEKNTEMCNVMMQLRKMANHPLLHRQYYTAEKLKEMSQLMLKEPTHCEANPDLIFEDMEVMTDFELHVLCKQYQHINSYQLDMDLILDSGKFRTLGCILSELKQKGDRVVLFSQFTMMLDILEVLLKHHQHRYLRLDGKTQISERIHLIDEFNTDMDIFVFLLSTKAGGLGINLTSANVVILHDIDCNPYNDKQAEDRCHRVGQTKEVLVIKLISQGTIEESMLKINQQKLKLEQDMTTVDEADEGSMPADIATLLKTSMGL
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: Protein that possesses intrinsic ATP-dependent nucleosome-remodeling activity and is both required for DNA repair and heterochromatin organization. Combines the ATP-dependent ability to exchange histones, with the chaperone-like ATP-independent activity to deposit histones and assemble nucleosomes. Promotes DNA end resection of double-strand breaks (DSBs) following DNA damage: probably acts by weakening histone DNA interactions in nucleosomes flanking DSBs. Required for the restoration of heterochromatin organization after replication. Acts at replication sites to facilitate the maintenance of heterochromatin by directing H3 and H4 histones deacetylation, H3 'Lys-9' trimethylation (H3K9me3) and restoration of silencing. {ECO:0000250|UniProtKB:Q9H4L7}.
uniprot
proteins
mass_dalton
116788
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at the C-terminus promotes histone binding but impedes nucleosome binding. Phosphorylation impedes ATPase activity and histone exchange activity. {ECO:0000250|UniProtKB:Q9H4L7}.
uniprot
proteins
protein_family
SNF2/RAD54 helicase family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
1024
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H4L7}. Chromosome {ECO:0000250|UniProtKB:Q9H4L7}. Note=Colocalizes with PCNA at replication forks during S phase. Recruited to double-strand breaks (DSBs) sites of DNA damage. {ECO:0000250|UniProtKB:Q9H4L7}.
uniprot
proteins