Ldaf1
entrez
378467
canonical
uniprot
Q6UK00
canonical
ensembl
ENSRNOG00000048250
resolver
ensp
ENSRNOP00000065085
resolver
enst
ENSRNOT00000075003
resolver
genesymbol
Ldaf1
resolver
genesymbol_syn
Tmem159
resolver
uniprot
A0A0G2JSZ8
resolver
uniprot
Q6DGG2
resolver
uniprot_entry
A0A0G2JSZ8_RAT
resolver
uniprot_entry
LDAF1_RAT
resolver
uniprot_sec
Q6DGG2
resolver
amino_acid_sequence
MAEEEPSSVSRDLQELQRKLGLLLESFQNNSKVVAFMKSPVGRFLDRHPFLVLTVLMFVTMSAIPVGFFLLIVVLTSLGALMGAILLEGLVISVCGLSLLCILCGLGFVSLALSGITMMSYVVVSCLMSYWFSPSRPPTQQHANIDSQLAMKFTESEKLGL
uniprot
proteins
function
FUNCTION: Plays an important role in the formation of lipid droplets during the differentiation and maturation of adipocytes. Together with seipin (BSCL2), defines the sites of lipid droplet formation in the endoplasmic reticulum and promotes the aggregation of triacylglycerol molecules to form the core of a lipid droplet (nucleation) in the endoplasmic reticulum and drive budding of lipid droplets into the cytoplasm. {ECO:0000250|UniProtKB:Q96B96}.
uniprot
proteins
mass_dalton
17578
uniprot
proteins
protein_family
LDAF1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15589683
uniprot
proteins
sequence_length
161
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q96B96}; Multi-pass membrane protein {ECO:0000255}. Lipid droplet {ECO:0000250|UniProtKB:Q96B96}. Note=Co-localizes with BSCL2 in the ER, upon LD formation dissociates from BSCL2 and relocalizes to LD surfaces during LD maturation. {ECO:0000250|UniProtKB:Q96B96}.
uniprot
proteins
transmembrane_region
TRANSMEM 44..61; /note="Helical"; /evidence="ECO:0000305"; TRANSMEM 68..87; /note="Helical"; /evidence="ECO:0000305"; TRANSMEM 94..110; /note="Helical"; /evidence="ECO:0000305"; TRANSMEM 117..133; /note="Helical"; /evidence="ECO:0000305
uniprot
proteins