THOC7
entrez
80145
canonical
uniprot
Q6I9Y2
canonical
ensembl
ENSG00000163634
resolver
ensp
ENSP00000295899
resolver
ensp
ENSP00000418518
resolver
enst
ENST00000295899
resolver
enst
ENST00000469584
resolver
genesymbol
THOC7
resolver
genesymbol_syn
NIF3L1BP1
resolver
hgnc
HGNC:29874
resolver
uniprot
A0A5S6STF9
resolver
uniprot
Q6P1L3
resolver
uniprot
Q8WUF2
resolver
uniprot
Q9H5H0
resolver
uniprot_entry
A0A5S6STF9_HUMAN
resolver
uniprot_entry
THOC7_HUMAN
resolver
uniprot_sec
Q6P1L3
resolver
uniprot_sec
Q8WUF2
resolver
uniprot_sec
Q9H5H0
resolver
amino_acid_sequence
MGAVTDDEVIRKRLLIDGDGAGDDRRINLLVKSFIKWCNSGSQEEGYSQYQRMLSTLSQCEFSMGKTLLVYDMNLREMENYEKIYKEIECSIAGAHEKIAECKKQILQAKRIRKNRQEYDALAKVIQHHPDRHETLKELEALGKELEHLSHIKESVEDKLELRRKQFHVLLSTIHELQQTLENDEKLSEVEEAQEASMETDPKP
uniprot
proteins
function
FUNCTION: Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA (PubMed:15833825, PubMed:15998806, PubMed:17190602). Required for efficient export of polyadenylated RNA (PubMed:23222130). Plays a key structural role in the oligomerization of the THO-DDX39B complex (PubMed:33191911). TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway (PubMed:15833825, PubMed:15998806, PubMed:17190602). {ECO:0000269|PubMed:15833825, ECO:0000269|PubMed:15998806, ECO:0000269|PubMed:17190602, ECO:0000269|PubMed:23222130, ECO:0000269|PubMed:33191911}.; FUNCTION: (Microbial infection) The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. {ECO:0000269|PubMed:18974867}.
uniprot
proteins
mass_dalton
23743
uniprot
proteins
protein_family
THOC7 family
uniprot
proteins
pubmed
12951069
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15833825
uniprot
proteins
pubmed
15998806
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17190602
uniprot
proteins
pubmed
18974867
uniprot
proteins
pubmed
19059247
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23222130
uniprot
proteins
pubmed
25489052
uniprot
proteins
pubmed
33191911
uniprot
proteins
pubmed
37020021
uniprot
proteins
sequence_length
204
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12951069}. Nucleus {ECO:0000269|PubMed:12951069, ECO:0000269|PubMed:19059247}. Nucleus speckle {ECO:0000305}. Note=Interaction with THOC5 is required for nuclear localization. {ECO:0000269|PubMed:19059247}.
uniprot
proteins