LILRA2
entrez
11027
canonical
uniprot
Q8N149
canonical
ensembl
ENSG00000239998
resolver
ensembl
ENSG00000274000
resolver
ensembl
ENSG00000275290
resolver
ensembl
ENSG00000278634
resolver
ensp
ENSP00000375617
resolver
ensp
ENSP00000375618
resolver
ensp
ENSP00000478981
resolver
ensp
ENSP00000479743
resolver
ensp
ENSP00000479914
resolver
ensp
ENSP00000480939
resolver
ensp
ENSP00000481338
resolver
ensp
ENSP00000483906
resolver
ensp
ENSP00000484762
resolver
ensp
ENSP00000559341
resolver
ensp
ENSP00000719932
resolver
enst
ENST00000391737
resolver
enst
ENST00000611940
resolver
enst
ENST00000613573
resolver
enst
ENST00000616629
resolver
enst
ENST00000617409
resolver
enst
ENST00000620279
resolver
enst
ENST00000621721
resolver
enst
ENST00000622640
resolver
genesymbol
LILRA2
resolver
genesymbol_syn
ILT1
resolver
genesymbol_syn
LIR7
resolver
hgnc
HGNC:6603
resolver
uniprot
A8MZH0
resolver
uniprot
O75020
resolver
uniprot_entry
A8MZH0_HUMAN
resolver
uniprot_entry
LIRA2_HUMAN
resolver
uniprot_sec
O75020
resolver
amino_acid_sequence
MTPILTVLICLGLSLGPRTHVQAGHLPKPTLWAEPGSVIIQGSPVTLRCQGSLQAEEYHLYRENKSASWVRRIQEPGKNGQFPIPSITWEHAGRYHCQYYSHNHSSEYSDPLELVVTGAYSKPTLSALPSPVVTSGGNVTLQCVSQVAFDGFILCKEGEDEHPQRLNSHSHARGWSWAIFSVGPVSPSRRWSYRCYAYDSNSPYVWSLPSDLLELLVPGVSKKPSLSVQPGPMVAPGESLTLQCVSDVGYDRFVLYKEGERDFLQRPGWQPQAGLSQANFTLGPVSPSHGGQYRCYSAHNLSSEWSAPSDPLDILITGQFYDRPSLSVQPVPTVAPGKNVTLLCQSRGQFHTFLLTKEGAGHPPLHLRSEHQAQQNQAEFRMGPVTSAHVGTYRCYSSLSSNPYLLSLPSDPLELVVSEAAETLSPSQNKTDSTTTSLGQHPQDYTVENLIRMGVAGLVLVVLGILLFEAQHSQRSLQDAAGR
uniprot
proteins
function
FUNCTION: Part of the innate immune responses against microbial infection (PubMed:12529506, PubMed:27572839). Specifically recognizes a set of N-terminally truncated immunoglobulins that are produced via cleavage by proteases from a range of pathogenic bacteria and fungi, including L.pneumophila, M.hyorhinis, S.pneumoniae, S.aureus and C.albicans (PubMed:27572839). Recognizes epitopes that are in part in the variable region of the immunoglobulin light chains, but requires also the constant region for signaling (PubMed:27572839). Binds to a subset of cleaved IgM, IgG3 and IgG4 molecules, but does not bind cleaved IgA1 (PubMed:27572839). Binding of N-terminally truncated immunoglobulins mediates activation of neutrophils (PubMed:27572839). In monocytes, activation leads to the release of CSF2, CF3, IL6, CXCL8 and CCL3 and down-regulates responses to bacterial lipopolysaccharide (LPS), possibly via down-regulation of TLR4 expression and reduced signaling via TLR4 (PubMed:22479404). In eosinophils, activation by ligand binding leads to the release of RNASE2, IL4 and leukotriene C4 (PubMed:12529506). Does not bind class I MHC antigens (PubMed:19230061). {ECO:0000269|PubMed:12529506, ECO:0000269|PubMed:19230061, ECO:0000269|PubMed:22479404, ECO:0000269|PubMed:27572839}.
uniprot
proteins
mass_dalton
52966
uniprot
proteins
pubmed
12529506
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19230061
uniprot
proteins
pubmed
19658091
uniprot
proteins
pubmed
22479404
uniprot
proteins
pubmed
27572839
uniprot
proteins
pubmed
9548455
uniprot
proteins
sequence_length
483
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12529506, ECO:0000269|PubMed:22479404, ECO:0000269|PubMed:27572839}; Single-pass type I membrane protein {ECO:0000305|PubMed:12529506, ECO:0000305|PubMed:22479404}.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted {ECO:0000303|PubMed:19658091}.
uniprot
proteins
transmembrane_region
TRANSMEM 450..470; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins