SLITRK2
entrez
84631
canonical
uniprot
Q9H156
canonical
ensembl
ENSG00000185985
resolver
ensp
ENSP00000334374
resolver
ensp
ENSP00000537920
resolver
ensp
ENSP00000537921
resolver
ensp
ENSP00000537922
resolver
ensp
ENSP00000537923
resolver
ensp
ENSP00000537924
resolver
ensp
ENSP00000537925
resolver
ensp
ENSP00000537927
resolver
ensp
ENSP00000636738
resolver
enst
ENST00000335565
resolver
genesymbol
SLITRK2
resolver
genesymbol_syn
CXorf2
resolver
genesymbol_syn
KIAA1854
resolver
genesymbol_syn
SLITL1
resolver
hgnc
HGNC:13449
resolver
uniprot
A8K117
resolver
uniprot
B3KTY4
resolver
uniprot
F8WA93
resolver
uniprot
Q2KHN3
resolver
uniprot
Q5JXB1
resolver
uniprot
Q8NBC7
resolver
uniprot
Q96JH3
resolver
uniprot_entry
B3KTY4_HUMAN
resolver
uniprot_entry
F8WA93_HUMAN
resolver
uniprot_entry
SLIK2_HUMAN
resolver
uniprot_sec
A8K117
resolver
uniprot_sec
Q2KHN3
resolver
uniprot_sec
Q5JXB1
resolver
uniprot_sec
Q8NBC7
resolver
uniprot_sec
Q96JH3
resolver
amino_acid_sequence
MLSGVWFLSVLTVAGILQTESRKTAKDICKIRCLCEEKENVLNINCENKGFTTVSLLQPPQYRIYQLFLNGNLLTRLYPNEFVNYSNAVTLHLGNNGLQEIRTGAFSGLKTLKRLHLNNNKLEILREDTFLGLESLEYLQADYNYISAIEAGAFSKLNKLKVLILNDNLLLSLPSNVFRFVLLTHLDLRGNRLKVMPFAGVLEHIGGIMEIQLEENPWNCTCDLLPLKAWLDTITVFVGEIVCETPFRLHGKDVTQLTRQDLCPRKSASDSSQRGSHADTHVQRLSPTMNPALNPTRAPKASRPPKMRNRPTPRVTVSKDRQSFGPIMVYQTKSPVPLTCPSSCVCTSQSSDNGLNVNCQERKFTNISDLQPKPTSPKKLYLTGNYLQTVYKNDLLEYSSLDLLHLGNNRIAVIQEGAFTNLTSLRRLYLNGNYLEVLYPSMFDGLQSLQYLYLEYNVIKEIKPLTFDALINLQLLFLNNNLLRSLPDNIFGGTALTRLNLRNNHFSHLPVKGVLDQLPAFIQIDLQENPWDCTCDIMGLKDWTEHANSPVIINEVTCESPAKHAGEILKFLGREAICPDSPNLSDGTVLSMNHNTDTPRSLSVSPSSYPELHTEVPLSVLILGLLVVFILSVCFGAGLFVFVLKRRKGVPSVPRNTNNLDVSSFQLQYGSYNTETHDKTDGHVYNYIPPPVGQMCQNPIYMQKEGDPVAYYRNLQEFSYSNLEEKKEEPATPAYTISATELLEKQATPREPELLYQNIAERVKELPSAGLVHYNFCTLPKRQFAPSYESRRQNQDRINKTVLYGTPRKCFVGQSKPNHPLLQAKPQSEPDYLEVLEKQTAISQL
uniprot
proteins
disease_involvement
DISEASE: Intellectual developmental disorder, X-linked 111 (XLID111) [MIM:301107]: A neurodevelopmental disorder characterized by moderate to severe intellectual disability, delayed development, speech delay, and neuropsychiatric and behavioral problems such as anxiety, attention deficit-hyperactivity disorder and autism spectrum disorder. {ECO:0000269|PubMed:35840571}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: It is involved in synaptogenesis and promotes excitatory synapse differentiation (PubMed:27273464, PubMed:27812321, PubMed:35840571). Suppresses neurite outgrowth (By similarity). Involved in the negative regulation of NTRK2 (PubMed:35840571). {ECO:0000250|UniProtKB:Q810C0, ECO:0000269|PubMed:27273464, ECO:0000269|PubMed:27812321, ECO:0000269|PubMed:35840571}.
uniprot
proteins
mass_dalton
95404
uniprot
proteins
protein_family
SLITRK family
uniprot
proteins
pubmed
11347906
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14557068
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
20479760
uniprot
proteins
pubmed
27273464
uniprot
proteins
pubmed
27812321
uniprot
proteins
pubmed
35840571
uniprot
proteins
sequence_length
845
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:27812321, ECO:0000269|PubMed:35840571}. Cell projection, dendrite {ECO:0000269|PubMed:35840571}.
uniprot
proteins
transmembrane_region
TRANSMEM 622..642; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins