Ier3
entrez
15937
canonical
uniprot
P46694
canonical
ensembl
ENSMUSG00000003541
resolver
ensp
ENSMUSP00000003635
resolver
enst
ENSMUST00000003635
resolver
genesymbol
Ier3
resolver
genesymbol_syn
Gly96
resolver
genesymbol_syn
Iex1
resolver
uniprot
Q4FJY1
resolver
uniprot
Q91VZ5
resolver
uniprot_entry
IEX1_MOUSE
resolver
uniprot_sec
Q4FJY1
resolver
uniprot_sec
Q91VZ5
resolver
amino_acid_sequence
MCHSRNHLHTMTGLRAPSPAPSTGPELRRGSGPEIFTFDPLPERAVVSTARLNTSRGHRKRSRRVLYPRVVRRQLPTEEPNIAKRVLFLLFAIIFCQILMAEEGVSQPLAPEDATSAVTPEPISAPITAPPVLEPLNLTSESSDYALDLKAFLQQHPAAF
uniprot
proteins
function
FUNCTION: May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Also acts as an ERK downstream effector mediating survival (By similarity). As a member of the NUPR1/RELB/IER3 survival pathway, may allow the development of pancreatic intraepithelial neoplasias. {ECO:0000250, ECO:0000269|PubMed:22565310}.
uniprot
proteins
mass_dalton
17655
uniprot
proteins
post_translational_modification
PTM: Glycosylated.
uniprot
proteins
protein_family
IER3 family
uniprot
proteins
pubmed
14644419
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22565310
uniprot
proteins
pubmed
8437864
uniprot
proteins
sequence_length
160
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 86..102; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins