Rab22a
entrez
19334
canonical
uniprot
P35285
canonical
ensembl
ENSMUSG00000027519
resolver
ensp
ENSMUSP00000029024
resolver
enst
ENSMUST00000029024
resolver
genesymbol
Rab22a
resolver
genesymbol_syn
Rab22
resolver
genesymbol_syn
Rab22A
resolver
uniprot
Q0PD34
resolver
uniprot
Q3UCA7
resolver
uniprot
Q91VD4
resolver
uniprot_entry
Q0PD34_MOUSE
resolver
uniprot_entry
RB22A_MOUSE
resolver
uniprot_sec
Q3UCA7
resolver
uniprot_sec
Q91VD4
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) including RINL, which promote the exchange of bound GDP for free GTP (By similarity). Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity (Probable). Inhibited by GDP dissociation inhibitors (GDIs) (Probable). {ECO:0000250|UniProtKB:Q9UL26, ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MALRELKVCLLGDTGVGKSSIVWRFVEDSFDPNINPTIGASFMTKTVQYQNELHKFLIWDTAGQERFRALAPMYYRGSAAAIIVYDITKEETFSTLKNWVRELRQHGPPSIVVAIAGNKCDLTDVREVMERDAKDYADSIHAIFVETSAKNAININELFIEISRRIPSTDANPASGGKGFKLRRQPSEPKRSCC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:19759177, PubMed:27718357). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB22A plays a role in endocytosis and intracellular protein transport (PubMed:19759177, PubMed:27718357). Mediates trafficking of transferrin/TF from early endosomes to recycling endosomes. Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth. Has low GTPase activity (By similarity). {ECO:0000250|UniProtKB:Q9UL26, ECO:0000269|PubMed:19759177, ECO:0000269|PubMed:27718357}.
uniprot
proteins
mass_dalton
21802
uniprot
proteins
mutagenesis
MUTAGEN 64; /note="Q->L: Constitutively active. Disrupts general recycling of receptors in embryonic fibroblasts."; /evidence="ECO:0000269|PubMed:27718357
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1555775
uniprot
proteins
pubmed
16034420
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19759177
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27718357
uniprot
proteins
pubmed
8126105
uniprot
proteins
sequence_length
194
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:27718357}; Lipid-anchor {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:P51154}; Lipid-anchor {ECO:0000305}. Early endosome {ECO:0000269|PubMed:19759177, ECO:0000269|PubMed:27718357}. Late endosome {ECO:0000250|UniProtKB:P51154}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q9UL26}. Cytoplasmic vesicle {ECO:0000269|PubMed:27718357}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q9UL26}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. {ECO:0000250|UniProtKB:Q9UL26}.
uniprot
proteins