GPR18
entrez
2841
canonical
uniprot
Q14330
canonical
ensembl
ENSG00000125245
resolver
ensp
ENSP00000343428
resolver
ensp
ENSP00000380610
resolver
ensp
ENSP00000380613
resolver
ensp
ENSP00000401611
resolver
enst
ENST00000340807
resolver
enst
ENST00000397470
resolver
enst
ENST00000397473
resolver
enst
ENST00000416594
resolver
genesymbol
GPR18
resolver
genesymbol_syn
GPCRW
resolver
hgnc
HGNC:4472
resolver
uniprot
Q6GTM3
resolver
uniprot
Q96HI6
resolver
uniprot
Q9H2L2
resolver
uniprot_entry
GPR18_HUMAN
resolver
uniprot_sec
Q6GTM3
resolver
uniprot_sec
Q96HI6
resolver
uniprot_sec
Q9H2L2
resolver
amino_acid_sequence
MITLNNQDQPVPFNSSHPDEYKIAALVFYSCIFIIGLFVNITALWVFSCTTKKRTTVTIYMMNVALVDLIFIMTLPFRMFYYAKDEWPFGEYFCQILGALTVFYPSIALWLLAFISADRYMAIVQPKYAKELKNTCKAVLACVGVWIMTLTTTTPLLLLYKDPDKDSTPATCLKISDIIYLKAVNVLNLTRLTFFFLIPLFIMIGCYLVIIHNLLHGRTSKLKPKVKEKSIRIIITLLVQVLVCFMPFHICFAFLMLGTGENSYNPWGAFTTFLMNLSTCLDVILYYIVSKQFQARVISVMLYRNYLRSMRRKSFRSGSLRSLSNINSEML
uniprot
proteins
function
FUNCTION: G protein-coupled receptor (GPCR) that plays a role in diverse physiological processes particularly within the immune and nervous systems (PubMed:21732409, PubMed:26195725). Becomes active when triggered by various endogenous ligands including endocannabinoid N-arachidonyl glycine (NAGly), delta-9-tetrahydrocannabinol or resolvin D2/RvD2 derived from the omega-3 fatty acid docosahexaenoic acid (DHA) (PubMed:16844083, PubMed:24762058, PubMed:26195725, PubMed:27572937). Upon RvD2 binding, facilitates the resolution of inflammation, aiding in tissue repair and homeostasis. Mechanistically, RvD2 ligation initiates Galphas protein coupling, activation of cAMP-PKA signaling pathway and phosphorylation of STAT3, leading to RvD2-stimulated macrophage phagocytosis (PubMed:27994074). Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis (PubMed:27572937). Activation by N-arachidonoyl glycine (NAGly) can also induce apoptosis in macrophages (By similarity). Plays a role in homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs) in small intestine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (By similarity). Also participates in hypotensive responses, mediating reduction in intraocular and blood pressure (By similarity). {ECO:0000250|UniProtKB:Q8K1Z6, ECO:0000269|PubMed:16844083, ECO:0000269|PubMed:21732409, ECO:0000269|PubMed:24762058, ECO:0000269|PubMed:26195725, ECO:0000269|PubMed:27572937, ECO:0000269|PubMed:27994074}.
uniprot
proteins
mass_dalton
38134
uniprot
proteins
mutagenesis
MUTAGEN 108; /note="A->N: Increased cell surface expression."; /evidence="ECO:0000269|PubMed:27018161
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16844083
uniprot
proteins
pubmed
21732409
uniprot
proteins
pubmed
24762058
uniprot
proteins
pubmed
26195725
uniprot
proteins
pubmed
27018161
uniprot
proteins
pubmed
27572937
uniprot
proteins
pubmed
27994074
uniprot
proteins
pubmed
9205118
uniprot
proteins
sequence_length
331
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24762058, ECO:0000269|PubMed:27018161}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:24762058}.
uniprot
proteins
transmembrane_region
TRANSMEM 27..47; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 57..77; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 96..116; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 139..159; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 192..212; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 233..253; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 269..289; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins