PSMA2
entrez
5683
canonical
uniprot
P25787
canonical
ensembl
ENSG00000106588
resolver
ensembl
ENSG00000256646
resolver
ensp
ENSP00000223321
resolver
ensp
ENSP00000455744
resolver
ensp
ENSP00000503278
resolver
ensp
ENSP00000503930
resolver
enst
ENST00000223321
resolver
enst
ENST00000442788
resolver
enst
ENST00000676779
resolver
enst
ENST00000677768
resolver
genesymbol
PSMA2
resolver
genesymbol_syn
HC3
resolver
genesymbol_syn
PSC3
resolver
hgnc
HGNC:9531
resolver
uniprot
A0A024RA52
resolver
uniprot
Q6ICS6
resolver
uniprot
Q9BU45
resolver
uniprot_entry
A0A024RA52_HUMAN
resolver
uniprot_entry
PSA2_HUMAN
resolver
uniprot_sec
Q6ICS6
resolver
uniprot_sec
Q9BU45
resolver
amino_acid_sequence
MAERGYSFSLTTFSPSGKLVQIEYALAAVAGGAPSVGIKAANGVVLATEKKQKSILYDERSVHKVEPITKHIGLVYSGMGPDYRVLVHRARKLAQQYYLVYQEPIPTAQLVQRVASVMQEYTQSGGVRPFGVSLLICGWNEGRPYLFQSDPSGAYFAWKATAMGKNYVNGKTFLEKRYNEDLELEDAIHTAILTLKESFEGQMTEDNIEVGICNEAGFRRLTPTEVKDYLAAIA
uniprot
proteins
function
FUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.
uniprot
proteins
mass_dalton
25899
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues; which may be important for nuclear import. {ECO:0000250|UniProtKB:P17220}.
uniprot
proteins
protein_family
Peptidase T1A family
uniprot
proteins
pubmed
11521686
uniprot
proteins
pubmed
12181345
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15244466
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16548883
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17323924
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
2025653
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23495936
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25599644
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26133119
uniprot
proteins
pubmed
27176742
uniprot
proteins
pubmed
27342858
uniprot
proteins
pubmed
27428775
uniprot
proteins
pubmed
27493187
uniprot
proteins
pubmed
34711951
uniprot
proteins
pubmed
7811265
uniprot
proteins
pubmed
8610016
uniprot
proteins
sequence_length
234
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Nucleus {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9 (PubMed:34711951). Colocalizes with TRIM5 in cytoplasmic bodies (By similarity). {ECO:0000250|UniProtKB:P49722, ECO:0000269|PubMed:34711951}.
uniprot
proteins