CD24
entrez
100133941
canonical
uniprot
P25063
canonical
ensembl
ENSG00000272398
resolver
ensp
ENSP00000475625
resolver
ensp
ENSP00000481841
resolver
ensp
ENSP00000483838
resolver
ensp
ENSP00000483985
resolver
genesymbol
CD24
resolver
genesymbol_syn
CD24A
resolver
hgnc
HGNC:1645
resolver
uniprot
A0A087WYI6
resolver
uniprot
B6EC88
resolver
uniprot
Q16257
resolver
uniprot
Q53XS0
resolver
uniprot
R4I4T5
resolver
uniprot_entry
CD24_HUMAN
resolver
uniprot_sec
A0A087WYI6
resolver
uniprot_sec
B6EC88
resolver
uniprot_sec
Q16257
resolver
uniprot_sec
Q53XS0
resolver
uniprot_sec
R4I4T5
resolver
amino_acid_sequence
MGRAMVARLGLGLLLLALLLPTQIYSSETTTGTSSNSSQSTSNSGLAPNPTNATTKAAGGALQSTASLFVVSLSLLHLYS
uniprot
proteins
disease_involvement
DISEASE: Multiple sclerosis (MS) [MIM:126200]: A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. {ECO:0000269|PubMed:14657362}. Note=Disease susceptibility may be associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed:11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity). {ECO:0000250|UniProtKB:P24807, ECO:0000269|PubMed:11313396}.
uniprot
proteins
mass_dalton
8083
uniprot
proteins
post_translational_modification
PTM: Extensively O-glycosylated.
uniprot
proteins
protein_family
CD24 family
uniprot
proteins
pubmed
11313396
uniprot
proteins
pubmed
1327504
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14657362
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16344560
uniprot
proteins
pubmed
17411341
uniprot
proteins
pubmed
1831224
uniprot
proteins
pubmed
26444008
uniprot
proteins
pubmed
7736776
uniprot
proteins
pubmed
7959762
uniprot
proteins
pubmed
8753773
uniprot
proteins
sequence_length
80
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
uniprot
proteins