Gpr146
entrez
80290
canonical
uniprot
Q99LE2
canonical
ensembl
ENSMUSG00000044197
resolver
ensp
ENSMUSP00000049707
resolver
ensp
ENSMUSP00000098083
resolver
enst
ENSMUST00000051293
resolver
enst
ENSMUST00000100514
resolver
genesymbol
Gpr146
resolver
uniprot
Q3U3K8
resolver
uniprot
Q3U421
resolver
uniprot
Q8BHR6
resolver
uniprot
Q8BHU4
resolver
uniprot_entry
GP146_MOUSE
resolver
uniprot_sec
Q3U3K8
resolver
uniprot_sec
Q3U421
resolver
uniprot_sec
Q8BHR6
resolver
uniprot_sec
Q8BHU4
resolver
amino_acid_sequence
MWSCGPLNSTAWAEEPLCRNLRLGLWVLSLLYLGAGVPVSLGYNALLVLANLASKNTMTMPDVYFVNMAVAGLVLTALAPAYLLGPAHSRWALWSLSSEAHVTLLILFNVASLVTMYSTALLSLDYYIERALPRTYMASVYNTRHVCGFVWGGAVLTSFSSLLFYICSHVSSRIAECARMQNTEAADAILVLIGYVVPGLAVLYALALISRIGKEDTPLDQDTSRLDPSVHRLLVATVCTQFGLWTPYYLSLGHTVLTSRGRTVEGHYLGILQVAKDLAKFLAFSSSSVTPLLYRYINKAFPGKLRRLMKKMHCGRRHCSPDPSGIQQVMAQA
uniprot
proteins
function
FUNCTION: GPCR receptor required for the regulation of plasma cholesterol levels (PubMed:31778654, PubMed:38503280). Receptor for CHLSN, a gut derived hormone which mediates an inhibitory effect of intestinal cholesterol absorption on hepatic cholesterol synthesis. Cholesin-binding exerts an antagonistic effect by inhibiting PKA signaling and suppressing SREBF2-controlled cholesterol in the liver (PubMed:38503280). {ECO:0000269|PubMed:31778654, ECO:0000269|PubMed:38503280}.
uniprot
proteins
mass_dalton
36572
uniprot
proteins
mutagenesis
MUTAGEN 90; /note="R->A: Decreased affinity for CHLSN; when associated with A-101, A-169, A-179, A-187 and A-265."; /evidence="ECO:0000269|PubMed:38503280"; MUTAGEN 101; /note="H->A: Decreased affinity for CHLSN; when associated with A-90, A-169, A-179, A-187 and A-265."; /evidence="ECO:0000269|PubMed:38503280"; MUTAGEN 169; /note="H->A: Decreased affinity for CHLSN; when associated with A-90, A-101, A-179, A-187 and A-265."; /evidence="ECO:0000269|PubMed:38503280"; MUTAGEN 179; /note="R->A: Decreased affinity for CHLSN; when associated with A-90, A-101, A-169, A-187 and A-265."; /evidence="ECO:0000269|PubMed:38503280"; MUTAGEN 187; /note="D->A: Decreased affinity for CHLSN; when associated with A-90, A-101, A-169, A-179 and A-265."; /evidence="ECO:0000269|PubMed:38503280"; MUTAGEN 265; /note="E->A: Decreased affinity for CHLSN; when associated with A-90, A-101, A-169, A-179 and A-187."; /evidence="ECO:0000269|PubMed:38503280
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
31778654
uniprot
proteins
pubmed
38503280
uniprot
proteins
sequence_length
333
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:38503280}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..43; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 65..85; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 102..122; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 146..166; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 189..209; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 233..253; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 278..298; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins