Pitpnb
entrez
56305
canonical
uniprot
P53811
canonical
ensembl
ENSMUSG00000050017
resolver
ensp
ENSMUSP00000083835
resolver
ensp
ENSMUSP00000142732
resolver
enst
ENSMUST00000086635
resolver
enst
ENSMUST00000200298
resolver
genesymbol
Pitpnb
resolver
uniprot
A0A0G2JED8
resolver
uniprot
Q8JZZ5
resolver
uniprot_entry
A0A0G2JED8_MOUSE
resolver
uniprot_entry
PIPNB_MOUSE
resolver
uniprot_entry
Q8JZZ5_MOUSE
resolver
amino_acid_sequence
MVLIKEFRVVLPCSVQEYQVGQLYSVAEASKNETGGGEGIEVLKNEPYENDGEKGQYTHKIYHLKSKVPAFVRMIAPEGSLVFHEKAWNAYPYCRTIVTNEYMKDDFFIKIETWHKPDLGTLENVHGLDPNTWKTVEIVHIDIADRSQVEPADYKADEDPALFHSVKTKRGPLGPNWKKELANTPDCPRMCAYKLVTIKFKWWGLQSKVENFIQKQEKRIFTNLHRQLFCWIDKWIDLTMEDIRRMEDETQKELETMRKKGSVRGTSAADA
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of phosphatidylinositol, phosphatidylcholine and sphingomyelin between membranes (By similarity). Required for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum; phosphatidylinositol and phosphatidylcholine transfer activity is essential for this function (By similarity). {ECO:0000250|UniProtKB:P48739, ECO:0000250|UniProtKB:Q9TR36}.
uniprot
proteins
mass_dalton
31487
uniprot
proteins
mutagenesis
MUTAGEN 165; /note="S->A: No effect on phosphorylation by PKC; abolishes phospholipid transfer activity."; /evidence="ECO:0000269|PubMed:11953429"; MUTAGEN 262; /note="S->A: Abolishes phosphorylation by PKC and impairs Golgi targeting; no effect on phospholipid transfer activity."; /evidence="ECO:0000269|PubMed:11953429
uniprot
proteins
post_translational_modification
PTM: Constitutive phosphorylation of Ser-262 has no effect on phospholipid transfer activity but is required for Golgi targeting. {ECO:0000269|PubMed:11953429}.
uniprot
proteins
protein_family
PI transfer class I subfamily
uniprot
proteins
protein_family
PtdIns transfer protein family
uniprot
proteins
pubmed
11953429
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7654206
uniprot
proteins
sequence_length
271
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P53812}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P53812}; Peripheral membrane protein {ECO:0000250|UniProtKB:P53812}; Cytoplasmic side {ECO:0000250|UniProtKB:P53812}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P53812}; Peripheral membrane protein {ECO:0000250|UniProtKB:P53812}; Cytoplasmic side {ECO:0000250|UniProtKB:P53812}. Golgi apparatus {ECO:0000269|PubMed:7654206}. Note=Primarily cytosolic in its closed conformation, it becomes enriched on Golgi and endoplasmic reticulum membranes in its open state, where it mediates lipid transfer. {ECO:0000250|UniProtKB:P53812}.
uniprot
proteins