Tdh
entrez
58865
canonical
uniprot
Q8K3F7
canonical
ensembl
ENSMUSG00000021953
resolver
ensp
ENSMUSP00000022522
resolver
enst
ENSMUST00000022522
resolver
genesymbol
Tdh
resolver
uniprot
Q6PD91
resolver
uniprot
Q9JLU3
resolver
uniprot_entry
TDH_MOUSE
resolver
uniprot_sec
Q6PD91
resolver
uniprot_sec
Q9JLU3
resolver
amino_acid_sequence
MLFLGMLKQVVNGTAQSKASSCRKLVLPLKFLGTSQHRIPADANFHSTSISEAEPPRVLITGGLGQLGVGLANLLRKRFGKDNVILSDIRKPPAHVFHSGPFVYANILDYKSLREIVVNHRISWLFHYSALLSAVGEANVSLARDVNITGLHNVLDVAAEYNVRLFVPSTIGAFGPTSPRNPAPDLCIQRPRTIYGVSKVHTELMGEYYYYRYGLDFRCLRYPGIISADSQPGGGTTDYAVQIFHAAAKNGTFECNLEAGTRLPMMYISDCLRATLEVMEAPAERLSMRTYNISAMSFTPEELAQALRKHAPDFQITYCVDPLRQAIAESWPMILDDSNARKDWGWKHDFDLPELVATMLNFHGVSTRVAQVN
uniprot
proteins
ec_number
1.1.1.103
uniprot
proteins
function
FUNCTION: Catalyzes the NAD(+)-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate, mediating L-threonine catabolism. {ECO:0000269|PubMed:26492815}.
uniprot
proteins
mass_dalton
41462
uniprot
proteins
mutagenesis
MUTAGEN 133; /note="S->A: Decreased L-threonine 3-dehydrogenase activity."; /evidence="ECO:0000269|PubMed:26492815"; MUTAGEN 180; /note="R->K: Decreased L-threonine 3-dehydrogenase activity. No effect on protein NAD(+)-binding. No gross effect on protein folding. No effect on protein stability."; /evidence="ECO:0000269|PubMed:26492815"; MUTAGEN 237; /note="T->A: Decreased L-threonine 3-dehydrogenase activity."; /evidence="ECO:0000269|PubMed:26492815"; MUTAGEN 333; /note="M->A: Decreased L-threonine 3-dehydrogenase activity."; /evidence="ECO:0000269|PubMed:26492815"; MUTAGEN 333; /note="M->E: Decreased L-threonine 3-dehydrogenase activity. Decreased affinity for L-threonine."; /evidence="ECO:0000269|PubMed:26492815
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid degradation; L-threonine degradation via oxydo-reductase pathway; glycine from L-threonine: step 1/2. {ECO:0000305|PubMed:26492815}.
uniprot
proteins
protein_family
NAD(P)-dependent epimerase/dehydratase family
uniprot
proteins
pubmed
12097150
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
26492815
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q8MIR0}.
uniprot
proteins