Pla2g4b
entrez
211429
canonical
uniprot
P0C871
canonical
ensembl
ENSMUSG00000098488
resolver
ensp
ENSMUSP00000118458
resolver
enst
ENSMUST00000126150
resolver
genesymbol
Pla2g4b
resolver
uniprot
A2AP62
resolver
uniprot
B7ZCM8
resolver
uniprot
Q06G06
resolver
uniprot
Q4QQM1
resolver
uniprot
Q80VV8
resolver
uniprot
Q91W88
resolver
uniprot_entry
B7ZCM8_MOUSE
resolver
uniprot_entry
PA24B_MOUSE
resolver
uniprot_entry
Q06G06_MOUSE
resolver
uniprot_sec
A2AP62
resolver
uniprot_sec
Q4QQM1
resolver
uniprot_sec
Q80VV8
resolver
uniprot_sec
Q91W88
resolver
activity_regulation
ACTIVITY REGULATION: Activated by cytosolic Ca(2+) in the presence of cardiolipin. Activated by phosphoinositides. Inhibited by electrophilic ketone inhibitors. {ECO:0000269|PubMed:20705608}.
uniprot
proteins
amino_acid_sequence
MQAKVPETCLLTVRVLRASGLPSKDLVTSSDCYVTLNLPTASSHTLQTRTVKNSRNPVWNQNFHFRIHRQLKNVMELKVFDHDLVTRDDPVLSVLFDVGTLQIGTQRQSFSLGTQEKGCLEVEFRLQTLTDCEEQLISNGIVVARELSCLHVELKRTGDPKRSERKVQLVVAGACEGPQDASAGTGSFHFHYPACWEQELNVHLQDDPHEQLKVPLRTLPSSQLVRLVFPTSQEPLMRLELKKEEGPKELAVRLGCGPCPEEQAFLSKRKQVVAAALKKALQLDQDLHEDEIPVIAVMATGGGIRAMTSLYGQLAGLQELGLLDCISYITGASGSTWALANLYEDPEWSQKDLAGPTEVLKTQVTKSKLGALAPSQLWRYRQELAERARLGHPTCFTNLWALINEALLHDKPHEHKLSDQREALSRGQNPLPIYCALNSKEQGLSTFDFGEWCEFSPYEVGFPKYGAFISSELFGSEFFMGRLVKQLPESRICFLEGIWSNLFAASLQDSLYWSSEPSQFWDRWAQDQANLDKEQVPHLKIAEPPTMAGRIAELFTDLLTKRPLAHATHNFTRGLHFHKDYFQNSHFSAWKASKLDRLPNQLTPTEPHLCLLDVGYLINTSCPPLLQPTRDVDLILSLDYNLYGAFQQLQLLSRFCQEQGIPFPSISPSPEEQRQPQECHLFCDPAQPEAPAVLHFPLVNDSFQDYSAPGVPRTSEEKAAGEVNLSSSDSPYHYTKVTYSQEDVDKLLRLTHYNICNNQDRLREAMHQAVQRRRKRKQFRPE
uniprot
proteins
ec_number
3.1.1.4
uniprot
proteins
ec_number
3.1.1.5
uniprot
proteins
function
FUNCTION: Calcium-dependent phospholipase A1 and A2 and lysophospholipase that may play a role in membrane phospholipid remodeling. Cleaves the ester bond of the fatty acyl group attached to the sn-1 or sn-2 position of phospholipids (phospholipase A1 and A2 activity, respectively), producing lysophospholipids that may be used in deacylation-reacylation cycles. The PLA1 versus PLA2 activity ratio appears to depend on the phospholipid headgroup, with mainly PLA2 activity toward anionic phospholipids such as phosphatidylglycerols. Hydrolyzes with high efficiency lysophospholipids enabling complete deacylation. {ECO:0000269|PubMed:20705608}.
uniprot
proteins
mass_dalton
88448
uniprot
proteins
mutagenesis
MUTAGEN 24; /note="K->N: Impairs calcium-dependent binding to phospholipids; when associated with N-49 and N-52."; /evidence="ECO:0000269|PubMed:20705608"; MUTAGEN 44; /note="H->N: Significantly decreases calcium-dependent binding to phospholipids; when associated with N-82."; /evidence="ECO:0000269|PubMed:20705608"; MUTAGEN 49; /note="R->N: Impairs calcium-dependent binding to phospholipids; when associated with N-24 and N-52."; /evidence="ECO:0000269|PubMed:20705608"; MUTAGEN 52; /note="K->N: Impairs calcium-dependent binding to phospholipids; when associated with N-24 and N-49."; /evidence="ECO:0000269|PubMed:20705608"; MUTAGEN 78; /note="K->N: Significantly decreases calcium-dependent binding to phospholipids."; /evidence="ECO:0000269|PubMed:20705608"; MUTAGEN 82; /note="H->N: Significantly decreases calcium-dependent binding to phospholipids; when associated with N-44."; /evidence="ECO:0000269|PubMed:20705608
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20705608
uniprot
proteins
sequence_length
782
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P0C869}. Mitochondrion membrane {ECO:0000250|UniProtKB:P0C869}; Peripheral membrane protein {ECO:0000250|UniProtKB:P0C869}. Early endosome membrane {ECO:0000250|UniProtKB:P0C869}; Peripheral membrane protein {ECO:0000250|UniProtKB:P0C869}. Note=Translocates to membrane vesicles in a calcium-dependent fashion. {ECO:0000250|UniProtKB:P0C869}.
uniprot
proteins