CLEC7A
entrez
64581
canonical
uniprot
Q9BXN2
canonical
ensembl
ENSG00000172243
resolver
ensp
ENSP00000266456
resolver
ensp
ENSP00000298523
resolver
ensp
ENSP00000302569
resolver
ensp
ENSP00000312089
resolver
ensp
ENSP00000379743
resolver
ensp
ENSP00000431461
resolver
ensp
ENSP00000434954
resolver
ensp
ENSP00000630637
resolver
ensp
ENSP00000702706
resolver
ensp
ENSP00000702708
resolver
ensp
ENSP00000702709
resolver
enst
ENST00000525605
resolver
genesymbol
CLEC7A
resolver
genesymbol
DKFZp686L24211
resolver
genesymbol_syn
BGR
resolver
genesymbol_syn
CLEC7A
resolver
genesymbol_syn
CLECSF12
resolver
genesymbol_syn
DECTIN1
resolver
hgnc
HGNC:14558
resolver
uniprot
A0A0S2Z5Q1
resolver
uniprot
A0A2Z5YRT6
resolver
uniprot
A0A2Z5YRU4
resolver
uniprot
B2R861
resolver
uniprot
B7Z494
resolver
uniprot
B7Z5A9
resolver
uniprot
B7Z5B9
resolver
uniprot
F6UK94
resolver
uniprot
Q68D78
resolver
uniprot
Q6IPS7
resolver
uniprot
Q96D32
resolver
uniprot
Q96DR9
resolver
uniprot
Q96LD3
resolver
uniprot
Q96PA4
resolver
uniprot
Q96PA5
resolver
uniprot
Q96PA6
resolver
uniprot
Q96PA7
resolver
uniprot
Q96PA8
resolver
uniprot
Q9H1K3
resolver
uniprot_entry
A0A0S2Z5Q1_HUMAN
resolver
uniprot_entry
A0A2Z5YRT6_HUMAN
resolver
uniprot_entry
A0A2Z5YRU4_HUMAN
resolver
uniprot_entry
CLC7A_HUMAN
resolver
uniprot_entry
F6UK94_HUMAN
resolver
uniprot_entry
Q68D78_HUMAN
resolver
uniprot_sec
B2R861
resolver
uniprot_sec
B7Z494
resolver
uniprot_sec
B7Z5A9
resolver
uniprot_sec
B7Z5B9
resolver
uniprot_sec
Q6IPS7
resolver
uniprot_sec
Q96D32
resolver
uniprot_sec
Q96DR9
resolver
uniprot_sec
Q96LD3
resolver
uniprot_sec
Q96PA4
resolver
uniprot_sec
Q96PA5
resolver
uniprot_sec
Q96PA6
resolver
uniprot_sec
Q96PA7
resolver
uniprot_sec
Q96PA8
resolver
uniprot_sec
Q9H1K3
resolver
amino_acid_sequence
MEYHPDLENLDEDGYTQLHFDSQSNTRIAVVSEKGSCAASPPWRLIAVILGILCLVILVIAVVLGTMAIWRSNSGSNTLENGYFLSRNKENHSQPTQSSLEDSVTPTKAVKTTGVLSSPCPPNWIIYEKSCYLFSMSLNSWDGSKRQCWQLGSNLLKIDSSNELGFIVKQVSSQPDNSFWIGLSRPQTEVPWLWEDGSTFSSNLFQIRTTATQENPSPNCVWIHVSVIYDQLCSVPSYSICEKKFSM
uniprot
proteins
disease_involvement
DISEASE: Candidiasis, familial, 4 (CANDF4) [MIM:613108]: A primary immunodeficiency disorder with altered immune responses and impaired clearance of fungal infections, selective against Candida. It is characterized by persistent and/or recurrent infections of the skin, nails and mucous membranes caused by organisms of the genus Candida, mainly Candida albicans. {ECO:0000269|PubMed:19864674}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Lectin that functions as a pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi (PubMed:11567029, PubMed:12423684). Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (By similarity). Enhances cytokine production in macrophages and dendritic cells (By similarity). Mediates production of reactive oxygen species in the cell (By similarity). Mediates phagocytosis of C.albicans conidia (PubMed:17230442). Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans (By similarity). {ECO:0000250|UniProtKB:Q6QLQ4, ECO:0000269|PubMed:11567029, ECO:0000269|PubMed:12423684, ECO:0000269|PubMed:17230442}.
uniprot
proteins
mass_dalton
27627
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues in response to beta-glucan binding. {ECO:0000250|UniProtKB:Q6QLQ4}.
uniprot
proteins
pubmed
11470510
uniprot
proteins
pubmed
11491532
uniprot
proteins
pubmed
11567029
uniprot
proteins
pubmed
11745369
uniprot
proteins
pubmed
12423684
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
16870151
uniprot
proteins
pubmed
17182550
uniprot
proteins
pubmed
17230442
uniprot
proteins
pubmed
19864674
uniprot
proteins
pubmed
20807886
uniprot
proteins
sequence_length
247
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11745369, ECO:0000269|PubMed:16870151, ECO:0000269|PubMed:17182550, ECO:0000269|PubMed:17230442}; Single-pass type II membrane protein {ECO:0000269|PubMed:11745369, ECO:0000269|PubMed:16870151, ECO:0000269|PubMed:17230442}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 7]: Cytoplasm {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 45..65; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins