Pde6a
entrez
307401
canonical
uniprot
D3Z8C9
canonical
ensembl
ENSRNOG00000017816
resolver
ensembl
ENSRNOG00065020847
resolver
ensp
ENSRNOP00000024171
resolver
ensp
ENSRNOP00065028504
resolver
enst
ENSRNOT00000024171
resolver
enst
ENSRNOT00065035396
resolver
genesymbol
Pde6a
resolver
uniprot_entry
PDE6A_RAT
resolver
amino_acid_sequence
MGEVTAEEVEKFLDSNIGFAKQYYNFHYRGKVVSDLLGAKEAAVDFSNYHDVNRVEESEIIFDLLRDFQENLQAEKCTFNVMKKLCFLLRADRMSLFMYRTRNGIAELATRLFNVHKDAVLEDCLVMPDSEIVFPLDMGVVGHVAHSKKIANVPNTEEDEHFCDFVDSLTEYQTKSILASPIMNGKDVVAIIMAVNKIDEPHFTKRDEEILLKYLNFVNLIMKVFHLSYLHNCETRRGQILLWSGSKVFEELTDIERQFHKALYTVRAFLNCDRYSVGLLDMTKQKEFFDVWPVLMGEAPAYSGPRTPDGREINFYKVIDYILHGKEDIKVIPNPPADHWALVSGLPTYVAQNGLICNIMNAPAEDFFEFQKEPLDESGWMIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDDMDETLMESLTQFLGWSVLNPDTYESMNKLENRKDIFQDIVKYHVKCDNEEIQKILKTREVYGKEPWECEEEELAEILQEELPDAEKYEINKFHFSDLPLTELELVKCGIQMYYELRVVDKFHIPQEALVRFMYSLSKGYRRITYHNWRHGFNVGQTMFSLLMTGKLKRYFTDLEALAMVTAAFCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKTLLRDESLNIFQNLNRRQHEHAIHMMDIAIIATDLALYFKKRTMFQKIVDQSKTYESTQEWTQYMMLEQTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLQQNPIPMMDRNKADELPKLQVGFIDFVCTFVYKEFSRFHEEITPMLDGITNNRKEWKALADEYEARMKALEEEKQKQQAAKQAASGNQPGGNPSPGGAPASKSCCIQ
uniprot
proteins
ec_number
3.1.4.35
uniprot
proteins
function
FUNCTION: Catalytic alpha subunit of the rod-specific cGMP phosphodiesterase (PDE6) complex, which hydrolyzes 3',5'-cyclic GMP in the phototransduction cascade. The PDE6 holoenzyme consists of two catalytic subunits (PDE6A and PDE6B) and two inhibitory gamma subunits (PDE6G) (By similarity). Light-activated GNAT1 relieves gamma subunit-mediated inhibition, enabling the catalytic subunits to hydrolyze cGMP and thereby mediate visual signal transduction and amplification. Decreased cytosolic cGMP levels result in closure of cGMP-gated cation channels at the plasma membrane, leading to rod photoreceptor hyperpolarization (By similarity). {ECO:0000250|UniProtKB:P11541, ECO:0000250|UniProtKB:P16499}.
uniprot
proteins
mass_dalton
99752
uniprot
proteins
post_translational_modification
PTM: Farnesylated. This modification is required for association with the rod photoreceptor disk membrane. {ECO:0000269|PubMed:1309771}.
uniprot
proteins
protein_family
Cyclic nucleotide phosphodiesterase family
uniprot
proteins
pubmed
1309771
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
860
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Photoreceptor outer segment membrane {ECO:0000250|UniProtKB:P16499}; Lipid-anchor {ECO:0000269|PubMed:1309771}. Cell membrane {ECO:0000250|UniProtKB:P11541}; Lipid-anchor {ECO:0000269|PubMed:1309771}; Cytoplasmic side {ECO:0000250|UniProtKB:P11541}.
uniprot
proteins