Atp1a1
entrez
24211
canonical
uniprot
P06685
canonical
ensembl
ENSRNOG00000030019
resolver
ensembl
ENSRNOG00055019753
resolver
ensembl
ENSRNOG00060028283
resolver
ensembl
ENSRNOG00065029722
resolver
ensp
ENSRNOP00000045650
resolver
ensp
ENSRNOP00055027434
resolver
ensp
ENSRNOP00060041161
resolver
ensp
ENSRNOP00065042372
resolver
enst
ENSRNOT00000040430
resolver
enst
ENSRNOT00055033788
resolver
enst
ENSRNOT00060049314
resolver
enst
ENSRNOT00065051454
resolver
genesymbol
Atp1a1
resolver
uniprot
Q64609
resolver
uniprot_entry
AT1A1_RAT
resolver
uniprot_sec
Q64609
resolver
amino_acid_sequence
MGKGVGRDKYEPAAVSEHGDKKSKKAKKERDMDELKKEVSMDDHKLSLDELHRKYGTDLSRGLTPARAAEILARDGPNALTPPPTTPEWVKFCRQLFGGFSMLLWIGAILCFLAYGIRSATEEEPPNDDLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSINAEDVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETRNIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAEEIEHFIHLITGVAVFLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWFALSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIEVCCGSVMEMREKYTKIVEIPFNSTNKYQLSIHKNPNASEPKHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDAFQNAYLELGGLGERVLGFCHLLLPDEQFPEGFQFDTDEVNFPVDNLCFVGLISMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVNQVNPRDAKACVVHGSDLKDMTSEELDDILRYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIVGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPKTDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPFHLLGIRETWDDRWINDVEDSYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMGAALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKETYY
uniprot
proteins
ec_number
7.2.2.13
uniprot
proteins
function
FUNCTION: Catalytic subunit of the Na(+)/K(+)-ATPase pump that hydrolyzes ATP to exchange ions across the plasma membrane, exporting 3 Na(+) and importing 2 K(+) per cycle against electrochemical gradients. It undergoes ATP-driven conformational changes that allow alternating binding and release of Na(+) and K(+) ions across the membrane (PubMed:17939993, PubMed:30388404). This process maintains essential Na(+) and K(+) gradients for membrane potential and cellular function. Could also be part of an osmosensory signaling pathway that senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake to regulate sodium homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8VDN2, ECO:0000269|PubMed:17939993, ECO:0000269|PubMed:30388404}.
uniprot
proteins
mass_dalton
113054
uniprot
proteins
mutagenesis
MUTAGEN 16; /note="S->A: Dopamine fails to increase phosphoinositide-3 kinase activity and to promote its interaction with Na(+)/K(+) ATPase."; /evidence="ECO:0000269|PubMed:10823893"; MUTAGEN 83; /note="P->R: Dopamine fails to increase phosphoinositide-3 kinase activity and to promote its interaction with Na(+)/K(+) ATPase."; /evidence="ECO:0000269|PubMed:10823893"; MUTAGEN 302; /note="L->R: Results in altered sodium and potassium transport."; /evidence="ECO:0000269|PubMed:30388404"; MUTAGEN 303; /note="G->R: Results in altered sodium and potassium transport."; /evidence="ECO:0000269|PubMed:30388404"; MUTAGEN 314; /note="E->K: Abolishes targeting to the basolateral plasma membrane."; /evidence="ECO:0000269|PubMed:16914892"; MUTAGEN 859; /note="M->R: Results in altered sodium and potassium transport."; /evidence="ECO:0000269|PubMed:30388404
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Tyr-10 modulates pumping activity. Phosphorylation of Ser-943 by PKA modulates the response of ATP1A1 to PKC. Dephosphorylation by protein phosphatase 2A (PP2A) following increases in intracellular sodium, leading to increase catalytic activity. {ECO:0000269|PubMed:10473631, ECO:0000269|PubMed:17939993, ECO:0000269|PubMed:7510709, ECO:0000269|PubMed:7775468, ECO:0000269|PubMed:9435504}.
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type IIC subfamily
uniprot
proteins
pubmed
10473631
uniprot
proteins
pubmed
10823893
uniprot
proteins
pubmed
12730684
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15743908
uniprot
proteins
pubmed
16914892
uniprot
proteins
pubmed
17283221
uniprot
proteins
pubmed
17939993
uniprot
proteins
pubmed
19339511
uniprot
proteins
pubmed
2166579
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23532852
uniprot
proteins
pubmed
2822682
uniprot
proteins
pubmed
2822726
uniprot
proteins
pubmed
29499166
uniprot
proteins
pubmed
2994074
uniprot
proteins
pubmed
3028470
uniprot
proteins
pubmed
30388404
uniprot
proteins
pubmed
7510709
uniprot
proteins
pubmed
7775468
uniprot
proteins
pubmed
9435504
uniprot
proteins
sequence_length
1023
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8VDN2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P05023}. Basolateral cell membrane {ECO:0000269|PubMed:16914892}; Multi-pass membrane protein {ECO:0000255}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P05023}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P05023}. Cell projection, axon {ECO:0000269|PubMed:29499166}. Melanosome {ECO:0000250|UniProtKB:P05023}.
uniprot
proteins
transmembrane_region
TRANSMEM 92..116; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P05023"; TRANSMEM 128..148; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P05023"; TRANSMEM 291..312; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P05023"; TRANSMEM 319..342; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P05023"; TRANSMEM 773..795; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P05023"; TRANSMEM 804..822; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P05023"; TRANSMEM 845..870; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P05023"; TRANSMEM 918..938; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P05023"; TRANSMEM 952..970; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P05023"; TRANSMEM 985..1008; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P05023, ECO:0000255
uniprot
proteins