PGAM5
entrez
192111
canonical
uniprot
Q96HS1
canonical
ensembl
ENSG00000247077
resolver
ensp
ENSP00000321503
resolver
ensp
ENSP00000438465
resolver
ensp
ENSP00000516057
resolver
enst
ENST00000704860
resolver
genesymbol
PGAM5
resolver
hgnc
HGNC:28763
resolver
uniprot
A0A994J4Y8
resolver
uniprot
A9LN06
resolver
uniprot
C9IZY7
resolver
uniprot
Q96JB0
resolver
uniprot_entry
A0A994J4Y8_HUMAN
resolver
uniprot_entry
PGAM5_HUMAN
resolver
uniprot_sec
A9LN06
resolver
uniprot_sec
C9IZY7
resolver
uniprot_sec
Q96JB0
resolver
amino_acid_sequence
MAFRQALQLAACGLAGGSAAVLFSAVAVGKPRAGGDAEPRPAEPPAWAGGARPGPGVWDPNWDRREPLSLINVRKRNVESGEEELASKLDHYKAKATRHIFLIRHSQYHVDGSLEKDRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAIETTDIISRHLPGVCKVSTDLLREGAPIEPDPPVSHWKPEAVQYYEDGARIEAAFRNYIHRADARQEEDSYEIFICHANVIRYIVCRALQFPPEGWLRLSLNNGSITHLVIRPNGRVALRTLGDTGFMPPDKITRS
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Mitochondrial serine/threonine phosphatase that dephosphorylates various substrates and thus plays a role in different biological processes including cellular senescence or mitophagy (PubMed:24746696, PubMed:32439975). Modulates cellular senescence by regulating mitochondrial dynamics. Mechanistically, participates in mitochondrial fission through dephosphorylating DNM1L/DRP1 (PubMed:32439975). Additionally, dephosphorylates MFN2 in a stress-sensitive manner and consequently protects it from ubiquitination and degradation to promote mitochondrial network formation (PubMed:37498743). Regulates mitophagy independent of PARKIN by interacting with and dephosphorylating FUNDC1, which interacts with LC3 (PubMed:24746696). Regulates anti-oxidative response by forming a tertiary complex with KEAP1 and NRF2 (PubMed:18387606). Regulates necroptosis by acting as a RIPK3 target and recruiting the RIPK1-RIPK3-MLKL necrosis 'attack' complex to mitochondria (PubMed:22265414). {ECO:0000269|PubMed:18387606, ECO:0000269|PubMed:19590015, ECO:0000269|PubMed:22265414, ECO:0000269|PubMed:24746696, ECO:0000269|PubMed:32439975, ECO:0000269|PubMed:37498743}.
uniprot
proteins
mass_dalton
32004
uniprot
proteins
mutagenesis
MUTAGEN 24; /note="S->F: Abolishes cleavage by PARL."; /evidence="ECO:0000269|PubMed:22915595"; MUTAGEN 79; /note="E->A: Loss of interaction with KEAP1; when associated with A-80."; /evidence="ECO:0000269|PubMed:17046835"; MUTAGEN 80; /note="S->A: Loss of interaction with KEAP1; when associated with A-79."; /evidence="ECO:0000269|PubMed:17046835"; MUTAGEN 105; /note="H->A: Loss of phosphatase activity."; /evidence="ECO:0000269|PubMed:19590015, ECO:0000269|PubMed:37498743
uniprot
proteins
post_translational_modification
PTM: Both isoform 1 and isoform 2 are phosphorylated by the RIPK1/RIPK3 complex under necrotic conditions. This phosphorylation increases PGAM5 phosphatase activity.; PTM: Proteolytically cleaved by PARL in response to loss of mitochondrial membrane potential. {ECO:0000269|PubMed:22915595}.; PTM: Ubiquitinated by the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex composed of at least CUL3, KLHL6 and RBX1; leading to proteasomal degradation. {ECO:0000269|PubMed:41535474}.
uniprot
proteins
protein_family
BPG-dependent PGAM subfamily
uniprot
proteins
protein_family
Phosphoglycerate mutase family
uniprot
proteins
pubmed
11283018
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17046835
uniprot
proteins
pubmed
18387606
uniprot
proteins
pubmed
19590015
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22265414
uniprot
proteins
pubmed
22915595
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24746696
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
32439975
uniprot
proteins
pubmed
37498743
uniprot
proteins
pubmed
41535474
uniprot
proteins
sequence_length
289
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:18387606}; Single-pass membrane protein {ECO:0000255}. Mitochondrion inner membrane {ECO:0000269|PubMed:22915595, ECO:0000269|PubMed:24746696, ECO:0000269|PubMed:37498743}; Single-pass membrane protein {ECO:0000255}. Note=Isoform 2 overexpression results in the formation of disconnected punctuate mitochondria distributed throughout the cytoplasm. Isoform 1 overexpression results in the clustering of mitochondria around the nucleus.
uniprot
proteins
transmembrane_region
TRANSMEM 7..29; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins