Myo7a
entrez
17921
canonical
uniprot
P97479
canonical
ensembl
ENSMUSG00000030761
resolver
ensp
ENSMUSP00000082046
resolver
ensp
ENSMUSP00000102739
resolver
ensp
ENSMUSP00000102744
resolver
ensp
ENSMUSP00000102745
resolver
ensp
ENSMUSP00000146165
resolver
enst
ENSMUST00000084979
resolver
enst
ENSMUST00000107122
resolver
genesymbol
Myo7a
resolver
genesymbol_syn
Myo7
resolver
uniprot
A0A0R4J113
resolver
uniprot
E9QLP7
resolver
uniprot
F6ZLT7
resolver
uniprot
Q5MJ56
resolver
uniprot
Q5MJ57
resolver
uniprot_entry
A0A0R4J113_MOUSE
resolver
uniprot_entry
F6ZLT7_MOUSE
resolver
uniprot_entry
MYO7A_MOUSE
resolver
uniprot_entry
Q5MJ56_MOUSE
resolver
uniprot_sec
E9QLP7
resolver
uniprot_sec
Q5MJ57
resolver
amino_acid_sequence
MVILQKGDYVWMDLKSGQEFDVPIGAVVKLCDSGQIQVVDDEDNEHWISPQNATHIKPMHPTSVHGVEDMIRLGDLNEAGILRNLLIRYRDHLIYTYTGSILVAVNPYQLLSIYSPEHIRQYTNKKIGEMPPHIFAIADNCYFNMKRNNRDQCCIISGESGAGKTESTKLILQFLAAISGQHSWIEQQVLEATPILEAFGNAKTIRNDNSSRFGKYIDIHFNKRGAIEGAKIEQYLLEKSRVCRQAPDERNYHVFYCMLEGMNEEEKKKLGLGQAADYNYLAMGNCITCEGRVDSQEYANIRSAMKVLMFTDTENWEISKLLAAILHMGNLQYEARTFENLDACEVLFSPSLATAASLLEVNPPDLMSCLTSRTLITRGETVSTPLSREQALDVRDAFVKGIYGRLFVWIVEKINAAIYKPPPLEVKNSRRSIGLLDIFGFENFTVNSFEQLCINFANEHLQQFFVRHVFKLEQEEYDLESIDWLHIEFTDNQEALDMIANRPMNVISLIDEESKFPKGTDATMLHKLNSQHKLNANYVPPKNSHETQFGINHFAGVVYYESQGFLEKNRDTLHGDIIQLVHSSRNKFIKQIFQADVAMGAETRKRSPTLSSQFKRSLELLMRTLGACQPFFVRCIKPNEFKKPMLFDRHLCVRQLRYSGMMETIRIRHAGYPIRYSFVEFVERYRVLLPGVKPAYKQGDLRGTCQRMAEAVLGTHDDWQIGKTKIFLKDHHDMLLEVERDKAITDRVILLQKVIRGFKDRSNFLRLKSAATLIQRHWRGHHCRKNYELIRLGFLRLQALHRSRKLHKQYRLARQRIIEFQARCRAYLVRKAFRHRLWAVITVQAYARGMIARRLHRRLRVEYQRRLEAERMRLAEEEKLRKEMSAKKAKEEAERKHQERLAQLAREDAERELKEKEEARRKKELLEQMEKARHEPINHSDMVDKMFGFLGTSGSLPGQEGQAPSGFEDLERGRREMVEEDVDAALPLPDEDEEDLSEYKFAKFAATYFQGTTTHSYTRRPLKQPLLYHDDEGDQLAALAVWITILRFMGDLPEPKYHTAMSDGSEKIPVMTKIYETLGKKTYKRELQALQGEGETQLPEGQKKTSVRHKLVHLTLKKKSKLTEEVTKRLNDGESTVQGNSMLEDRPTSNLEKLHFIIGNGILRPALRDEIYCQISKQLTHNPSKSSYARGWILVSLCVGCFAPSEKFVKYLRNFIHGGPPGYAPYCEERLRRTFVNGTRTQPPSWLELQATKSKKPIMLPVTFMDGTTKTLLTDSATTARELCNALADKISLKDRFGFSLYIALFDKVSSLGSGSDHVMDAISQCEQYAKEQGAQERNAPWRLFFRKEVFTPWHNPSEDNVATNLIYQQVVRGVKFGEYRCEKEDDLAELASQQYFVDYGSEMILERLLSLVPTYIPDREITPLKNLEKWAQLAIAAHKKGIYAQRRTDSQKVKEDVVNYARFKWPLLFSRFYEAYKFSGPPLPKSDVIVAVNWTGVYFVDEQEQVLLELSFPEIMAVSSSRECRVLLSLGCSDLGCATCQSGRAGLTPAGPCSPCWSCRGTKMMAPSFTLATIKGDEYTFTSSNAEDIRDLVVTFLEGLRKRSKYVVALQDNPNPAGEESGFLSFAKGDLIILDHDTGEQVMNSGWANGINERTKQRGDFPTDCVYVMPTVTLPPREIVALVTMTPDQRQDVVRLLQLRTAEPEVRAKPYTLEEFSYDYFRPPPKHTLSRVMVSKARGKDRLWSHTREPLKQALLKKILGSEELSQEACMAFVAVLKYMGDYPSKRMRSVNELTDQIFEWALKAEPLKDEAYVQILKQLTDNHIRYSEERGWELLWLCTGLFPPSNILLPHVQRFLQSRKHCPLAIDCLQRLQKALRNGSRKYPPHLVEVEAIQHKTTQIFHKVYFPDDTDEAFEVESSTKAKDFCQNIASRLLLKSSEGFSLFVKIADKVISVPENDFFFDFVRHLTDWIKKARPIKDGIVPSLTYQVFFMKKLWTTTVPGKDPMADSIFHYYQELPKYLRGYHKCTREEVLQLGALIYRVKFEEDKSYFPSIPKLLRELVPQDLIRQVSPDDWKRSIVAYFNKHAGKSKEEAKLAFLKLIFKWPTFGSAFFEVKQTTEPNFPEILLIAINKYGVSLIDPRTKDILTTHPFTKISNWSSGNTYFHITIGNLVRGSKLLCETSLGYKMDDLLTSYISQMLTAMSKQRNSRSGR
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Myo7a are the cause of the shaker-1 (sh-1) phenotype which affects only the inner ear. Sh-1 homozygote mutants show hyperactivity, head tossing and circling due to vestibular dysfunction, together with typical neuroepithelial-type cochlear defects involving dysfunction and progressive degeneration of the organ of Corti. {ECO:0000269|PubMed:7870172}.
uniprot
proteins
function
FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which are then moved relative to actin filaments. In the retina, plays an important role in the renewal of the outer photoreceptor disks. Plays an important role in the distribution and migration of retinal pigment epithelial (RPE) melanosomes and phagosomes, and in the regulation of opsin transport in retinal photoreceptors. Mediates intracellular transport of RPE65 in the retina pigment epithelium. In the inner ear, plays an important role in differentiation, morphogenesis and organization of cochlear hair cell bundles. Motor protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing. Involved in hair-cell vesicle trafficking of aminoglycosides, which are known to induce ototoxicity. {ECO:0000269|PubMed:21493626, ECO:0000269|PubMed:21709241, ECO:0000269|PubMed:27525485}.
uniprot
proteins
mass_dalton
254939
uniprot
proteins
mutagenesis
MUTAGEN 1189; /note="A->E: Strongly reduced affinity for USH1G."; /evidence="ECO:0000269|PubMed:21311020"; MUTAGEN 1473; /note="F->Q: Reduced affinity for USH1G."; /evidence="ECO:0000269|PubMed:21311020
uniprot
proteins
protein_family
Myosin family
uniprot
proteins
protein_family
TRAFAC class myosin-kinesin ATPase superfamily
uniprot
proteins
pubmed
12221080
uniprot
proteins
pubmed
15590698
uniprot
proteins
pubmed
15654330
uniprot
proteins
pubmed
15976448
uniprot
proteins
pubmed
16481439
uniprot
proteins
pubmed
17567809
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19774077
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21311020
uniprot
proteins
pubmed
21493626
uniprot
proteins
pubmed
21709241
uniprot
proteins
pubmed
27331610
uniprot
proteins
pubmed
27525485
uniprot
proteins
pubmed
7870172
uniprot
proteins
pubmed
9680294
uniprot
proteins
sequence_length
2215
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21709241}. Cytoplasm, cell cortex {ECO:0000269|PubMed:21709241}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21709241}. Synapse {ECO:0000250|UniProtKB:Q13402}. Note=In the photoreceptor cells, mainly localized in the inner and base of outer segments as well as in the synaptic ending region (By similarity). In retinal pigment epithelial cells colocalizes with a subset of melanosomes, displays predominant localization to stress fiber-like structures and some localization to cytoplasmic puncta (By similarity). Detected at the tip of cochlear hair cell stereocilia (PubMed:27525485). The complex formed by MYO7A, USH1C and USH1G colocalizes with F-actin (By similarity). {ECO:0000250|UniProtKB:Q13402, ECO:0000269|PubMed:27525485}.
uniprot
proteins