Rfng
entrez
60433
canonical
uniprot
Q9R1U9
canonical
ensembl
ENSRNOG00000050298
resolver
ensp
ENSRNOP00000067562
resolver
ensp
ENSRNOP00000073554
resolver
enst
ENSRNOT00000075041
resolver
enst
ENSRNOT00000078052
resolver
genesymbol
Rfng
resolver
uniprot
A0A0G2K5T8
resolver
uniprot
M0RD65
resolver
uniprot
Q6P6T7
resolver
uniprot_entry
A0A0G2K5T8_RAT
resolver
uniprot_entry
M0RD65_RAT
resolver
uniprot_entry
Q6P6T7_RAT
resolver
uniprot_entry
RFNG_RAT
resolver
amino_acid_sequence
MSRVRRVLCRACLALAAVLAVLLLLPLPLPLPLPLPRAPAPDPGRVPTGSLTLEVSRLQPDDVFIAVKTTRKNHGPRLRLLLRTWISRAPRQTFIFTDGDDPELQLLAGSQMINTNCSAVRTRQALCCKMSVEYDKFIESGRKWFCHVDDDNYVNPKSLLHLLSTFSSNQDIYLGRPSLDHPIEATERVQGGGTSNTVKFWFATGGAGFCLSRGLALKMSPWASLGSFMSTAERVRLPDDCTVGYIVEGLLGARLLHSPLFHSHLENLQKLPSGAVLQQVTLSYGGPENPHNVVNVAGSFSIRQDPTRFQSVHCLLYPDTHWCPMKNRGKEAFQ
uniprot
proteins
ec_number
2.4.1.222
uniprot
proteins
function
FUNCTION: Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1 (By similarity). Inhibits Notch signaling in postmitotic neurons of the brain. It may play a role in adult brain and in neurogenesis (PubMed:11165380). It may play a role in limb development (By similarity). {ECO:0000250|UniProtKB:O09009, ECO:0000250|UniProtKB:O12972, ECO:0000269|PubMed:11165380}.
uniprot
proteins
mass_dalton
36993
uniprot
proteins
protein_family
Glycosyltransferase 31 family
uniprot
proteins
pubmed
11165380
uniprot
proteins
sequence_length
334
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..29; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins