GPR78
entrez
27201
canonical
uniprot
Q96P69
canonical
ensembl
ENSG00000155269
resolver
ensp
ENSP00000371927
resolver
enst
ENST00000382487
resolver
genesymbol
GPR78
resolver
hgnc
HGNC:4528
resolver
uniprot
B2R7M4
resolver
uniprot
Q8NGV3
resolver
uniprot_entry
B2R7M4_HUMAN
resolver
uniprot_entry
GPR78_HUMAN
resolver
uniprot_sec
Q8NGV3
resolver
amino_acid_sequence
MGPGEALLAGLLVMVLAVALLSNALVLLCCAYSAELRTRASGVLLVNLSLGHLLLAALDMPFTLLGVMRGRTPSAPGACQVIGFLDTFLASNAALSVAALSADQWLAVGFPLRYAGRLRPRYAGLLLGCAWGQSLAFSGAALGCSWLGYSSAFASCSLRLPPEPERPRFAAFTATLHAVGFVLPLAVLCLTSLQVHRVARRHCQRMDTVTMKALALLADLHPSVRQRCLIQQKRRRHRATRKIGIAIATFLICFAPYVMTRLAELVPFVTVNAQWGILSKCLTYSKAVADPFTYSLLRRPFRQVLAGMVHRLLKRTPRPASTHDSSLDVAGMVHQLLKRTPRPASTHNGSVDTENDSCLQQTH
uniprot
proteins
function
FUNCTION: Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. {ECO:0000269|PubMed:17363172}.
uniprot
proteins
mass_dalton
39332
uniprot
proteins
mutagenesis
MUTAGEN 236; /note="R->E: No effect on constitutive activity."; /evidence="ECO:0000269|PubMed:17363172
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11574155
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17363172
uniprot
proteins
sequence_length
363
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 48..68; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 81..101; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 123..143; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 169..189; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 243..263; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 278..297; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins