Npas4
entrez
225872
canonical
uniprot
Q8BGD7
canonical
ensembl
ENSMUSG00000045903
resolver
ensp
ENSMUSP00000062992
resolver
enst
ENSMUST00000056129
resolver
genesymbol
Npas4
resolver
genesymbol_syn
Nxf
resolver
uniprot
Q3V3U3
resolver
uniprot_entry
NPAS4_MOUSE
resolver
uniprot_sec
Q3V3U3
resolver
amino_acid_sequence
MYRSTKGASKARRDQINAEIRNLKELLPLAEADKVRLSYLHIMSLACIYTRKGVFFAGGTPLAGPTGLLSAQELEDIVAALPGFLLVFTAEGKLLYLSESVSEHLGHSMVDLVAQGDSIYDIIDPADHLTVRQQLTMPSALDADRLFRCRFNTSKSLRRQSSGNKLVLIRGRFHAHPPGAYWAGNPVFTAFCAPLEPRPRPGPGPGPGPGPASLFLAMFQSRHAKDLALLDVSESVLIYLGFERSELLCKSWYGLLHPEDLAQASSQHYRLLAESGDIQAEMVVRLQAKHGGWTWIYCMLYSEGPEGPFTANNYPISDTEAWSLRQQLNSEDTQAAYVLGTPAVLPSFSENVFSQEQCSNPLFTPSLGTPRSASFPRAPELGVISTPEELPQPSKELDFSYLPFPARPEPSLQADLSKDLVCTPPYTPHQPGGCAFLFSLHEPFQTHLPPPSSSLQEQLTPSTVTFSEQLTPSSATFPDPLTSSLQGQLTESSARSFEDQLTPCTSSFPDQLLPSTATFPEPLGSPAHEQLTPPSTAFQAHLNSPSQTFPEQLSPNPTKTYFAQEGCSFLYEKLPPSPSSPGNGDCTLLALAQLRGPLSVDVPLVPEGLLTPEASPVKQSFFHYTEKEQNEIDRLIQQISQLAQGVDRPFSAEAGTGGLEPLGGLEPLNPNLSLSGAGPPVLSLDLKPWKCQELDFLVDPDNLFLEETPVEDIFMDLSTPDPNGEWGSGDPEAEVPGGTLSPCNNLSPEDHSFLEDLATYETAFETGVSTFPYEGFADELHQLQSQVQDSFHEDGSGGEPTF
uniprot
proteins
function
FUNCTION: Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hippocampus (PubMed:18815592, PubMed:22194569, PubMed:23029555, PubMed:24201284, PubMed:24855953). Plays a key role in the structural and functional plasticity of neurons (PubMed:23172225). Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience (PubMed:24201284, PubMed:24855953). In excitatory neurons, activates transcription of BDNF, which in turn controls the number of GABA-releasing synapses that form on excitatory neurons, thereby promoting an increased number of inhibitory synapses on excitatory neurons (PubMed:18815592, PubMed:22194569, PubMed:24201284). In inhibitory neurons, regulates a distinct set of target genes that serve to increase excitatory input onto somatostatin neurons, probably resulting in enhanced feedback inhibition within cortical circuits (PubMed:24855953). The excitatory and inhibitory balance in neurons affects a number of processes, such as short-term and long-term memory, acquisition of experience, fear memory, response to stress and social behavior (PubMed:18815592, PubMed:22194569, PubMed:23029555, PubMed:24201284, PubMed:27238022). Acts as a regulator of dendritic spine development in olfactory bulb granule cells in a sensory-experience-dependent manner by regulating expression of MDM2 (PubMed:25088421). Efficient DNA binding requires dimerization with another bHLH protein, such as ARNT, ARNT2 or BMAL1 (PubMed:14701734, PubMed:15363889, PubMed:19284974). Can activate the CME (CNS midline enhancer) element (PubMed:14701734, PubMed:15363889). {ECO:0000269|PubMed:14701734, ECO:0000269|PubMed:15363889, ECO:0000269|PubMed:18815592, ECO:0000269|PubMed:22194569, ECO:0000269|PubMed:23029555, ECO:0000269|PubMed:23172225, ECO:0000269|PubMed:24201284, ECO:0000269|PubMed:24855953, ECO:0000269|PubMed:25088421, ECO:0000269|PubMed:27238022}.
uniprot
proteins
mass_dalton
87286
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, leading to degradation by the proteosome. {ECO:0000269|PubMed:26663079}.
uniprot
proteins
pubmed
14701734
uniprot
proteins
pubmed
15363889
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18815592
uniprot
proteins
pubmed
19001414
uniprot
proteins
pubmed
19284974
uniprot
proteins
pubmed
22194569
uniprot
proteins
pubmed
23029555
uniprot
proteins
pubmed
23172225
uniprot
proteins
pubmed
24201284
uniprot
proteins
pubmed
24291638
uniprot
proteins
pubmed
24855953
uniprot
proteins
pubmed
25088421
uniprot
proteins
pubmed
25549857
uniprot
proteins
pubmed
25911220
uniprot
proteins
pubmed
26663079
uniprot
proteins
pubmed
27189618
uniprot
proteins
pubmed
27238022
uniprot
proteins
pubmed
27782878
uniprot
proteins
sequence_length
802
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:15363889, ECO:0000269|PubMed:24201284}.
uniprot
proteins