TMEM120A
entrez
83862
canonical
uniprot
Q9BXJ8
canonical
ensembl
ENSG00000189077
resolver
ensp
ENSP00000473983
resolver
ensp
ENSP00000484736
resolver
ensp
ENSP00000667685
resolver
ensp
ENSP00000697882
resolver
enst
ENST00000439537
resolver
genesymbol
TMEM120A
resolver
genesymbol_syn
TACAN
resolver
genesymbol_syn
TMPIT
resolver
hgnc
HGNC:21697
resolver
uniprot
A0A087X266
resolver
uniprot
Q86TE9
resolver
uniprot
Q8N6P1
resolver
uniprot_entry
A0A087X266_HUMAN
resolver
uniprot_entry
TACAN_HUMAN
resolver
uniprot_sec
Q86TE9
resolver
uniprot_sec
Q8N6P1
resolver
amino_acid_sequence
MQPPPPGPLGDCLRDWEDLQQDFQNIQETHRLYRLKLEELTKLQNNCTSSITRQKKRLQELALALKKCKPSLPAEAEGAAQELENQMKERQGLFFDMEAYLPKKNGLYLSLVLGNVNVTLLSKQAKFAYKDEYEKFKLYLTIILILISFTCRFLLNSRVTDAAFNFLLVWYYCTLTIRESILINNGSRIKGWWVFHHYVSTFLSGVMLTWPDGLMYQKFRNQFLSFSMYQSFVQFLQYYYQSGCLYRLRALGERHTMDLTVEGFQSWMWRGLTFLLPFLFFGHFWQLFNALTLFNLAQDPQCKEWQVLMCGFPFLLLFLGNFFTTLRVVHHKFHSQRHGSKKD
uniprot
proteins
function
FUNCTION: Multifunctional protein involved in mechanosensation, and plays an essential role in lipid metabolism and adipocyte differentiation (PubMed:26024229, PubMed:36420836). May function as a potential ion channel involved in sensing mechanical stimuli (PubMed:35235791). Mediates the mechanosensitivity of the PKD2-TMEM120A channel complex through direct physical interaction (PubMed:36420836). TMEM120A seems to affect mechanosensation by inhibiting PIEZO2 channels, possibly by altering cellular lipid content (By similarity). TMEM120A is structurally similar to a lipid-modifying enzyme, ELOVL7, and contains a bound coenzyme A molecule, which suggests it might function as an enzyme in lipid metabolism (PubMed:34374645, PubMed:34409941, PubMed:34465718). Additionally, implicated in innate immune response against Zika virus. Acts as a key activator of the antiviral signaling involving STING1 (PubMed:35013224). {ECO:0000250|UniProtKB:Q8C1E7, ECO:0000269|PubMed:26024229, ECO:0000269|PubMed:34374645, ECO:0000269|PubMed:34409941, ECO:0000269|PubMed:34465718, ECO:0000269|PubMed:35013224, ECO:0000269|PubMed:35235791, ECO:0000269|PubMed:36420836}.
uniprot
proteins
mass_dalton
40610
uniprot
proteins
mutagenesis
MUTAGEN 193; /note="W->A: Decreases the binding affinity with CoA."; /evidence="ECO:0000269|PubMed:34409941"; MUTAGEN 207; /note="M->A: Increases membrane pressure-activated current."; /evidence="ECO:0000269|PubMed:35235791
uniprot
proteins
protein_family
TMEM120 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26024229
uniprot
proteins
pubmed
32084332
uniprot
proteins
pubmed
34374645
uniprot
proteins
pubmed
34409941
uniprot
proteins
pubmed
34465718
uniprot
proteins
pubmed
35013224
uniprot
proteins
pubmed
35235791
uniprot
proteins
pubmed
36420836
uniprot
proteins
sequence_length
343
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:35013224}; Multi-pass membrane protein {ECO:0000269|PubMed:34374645}. Nucleus inner membrane {ECO:0000250|UniProtKB:Q8C1E7}; Multi-pass membrane protein {ECO:0000269|PubMed:34374645}. Endoplasmic reticulum {ECO:0000269|PubMed:35013224}.
uniprot
proteins
transmembrane_region
TRANSMEM 133..152; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:34374645, ECO:0000312|PDB:7N7P"; TRANSMEM 159..177; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:34374645, ECO:0000312|PDB:7N7P"; TRANSMEM 191..209; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:34374645, ECO:0000312|PDB:7N7P"; TRANSMEM 219..240; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:34374645, ECO:0000312|PDB:7N7P"; TRANSMEM 271..294; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:34374645, ECO:0000312|PDB:7N7P"; TRANSMEM 305..330; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:34374645, ECO:0000312|PDB:7N7P
uniprot
proteins