Rab26
entrez
328778
canonical
uniprot
Q504M8
canonical
ensembl
ENSMUSG00000079657
resolver
ensp
ENSMUSP00000046089
resolver
enst
ENSMUST00000035797
resolver
genesymbol
Rab26
resolver
uniprot
Q0PD29
resolver
uniprot
Q148R0
resolver
uniprot_entry
Q148R0_MOUSE
resolver
uniprot_entry
RAB26_MOUSE
resolver
uniprot_sec
Q0PD29
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MSRKKTPKSKGGSEPATSTLPAAAAATNGPRLAHPRTVRPGPEAPPNGPPQSIRPSLGSTGDFYDVAFKVMLVGDSGVGKTCLLVRFKDGAFLAGTFISTVGIDFRNKVLDVDGMKVKLQIWDTAGQERFRSVTHAYYRDAHALLLLYDITNKDSFDNIQAWLTEIQEYAQQDVVLMLLGNKVDSTQDRVVKREDGEKLAKEYGLPFMETSARTGLNVDLAFTAIAKELKQRSAKAPSEPRFRLHDYVKREGRGVSCCRL
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB26 mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach (By similarity). Plays a role in the secretion of amylase from acinar granules in the parotid gland (By similarity). {ECO:0000250|UniProtKB:P51156, ECO:0000250|UniProtKB:P61006, ECO:0000250|UniProtKB:Q9ULW5}.
uniprot
proteins
mass_dalton
28619
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
12578829
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20038531
uniprot
proteins
sequence_length
260
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305|PubMed:20038531}; Lipid-anchor {ECO:0000305|PubMed:20038531}; Cytoplasmic side {ECO:0000305|PubMed:20038531}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9ULW5}; Lipid-anchor {ECO:0000250|UniProtKB:Q9ULW5}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9ULW5}. Note=Not localized at the plasma membrane (By similarity). Inhibition of S-geranylgeranyl cysteine formation abolishes membrane location. {ECO:0000250|UniProtKB:P51156}.
uniprot
proteins