Q8VIL2
uniprot
Q8VIL2
canonical
amino_acid_sequence
MAEEVRQELSALAAIFCGPNEWEMLSCSETDGAVFRIHTTAEGLVGEDVPLELAFHLPVGYPLCLPGISVTSEHLTRAQCVTAKEKLLGEARKLVSEPMVHELVLWIQQNLRLVLSQPETVSSHEKCTLPESATGDDGPWMTLLRLDHMRARTKYVKAVEKWASELRLTGRLMFMGKLILILLQGDRSNIKEYLILQKTSKVDVDSSGKKCKEKMISVLSETKVQTEHKRFLAFEVKEYSTLEELQKEFGAAGLGELFSECVLGLVK
uniprot
proteins
function
FUNCTION: Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Positively regulates the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Negatively regulates the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Has no effect on ubiquitination. {ECO:0000269|PubMed:22009797}.
uniprot
proteins
mass_dalton
29890
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
22009797
uniprot
proteins
sequence_length
267
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y3V2}. Cytoplasm {ECO:0000250|UniProtKB:Q9Y3V2}. Note=Colocalizes with UBC9/UBE2I in nuclear spots. {ECO:0000250}.
uniprot
proteins