Smtnl1
entrez
68678
canonical
uniprot
Q99LM3
canonical
ensembl
ENSMUSG00000027077
resolver
ensp
ENSMUSP00000028471
resolver
enst
ENSMUST00000028471
resolver
genesymbol
Smtnl1
resolver
uniprot_entry
SMTL1_MOUSE
resolver
amino_acid_sequence
MEQTEGNSSEDGTTVSPTAGNLETPGSQGIAEEVAEGTVGTSDKEGPSDWAEHLCKAASKSGESGGSPGEASILDELKTDLQGEARGKDEAQGDLAEEKVGKEDTTAASQEDTGKKEETKPEPNEVREKEEAMLASEKQKVDEKETNLESKEKSDVNDKAKPEPKEDAGAEVTVNEAETESQEEADVKDQAKPELPEVDGKETGSDTKELVEPESPTEEQEQGKENESEERAAVIPSSPEEWPESPTDEGPSLSPDGLAPESTGETSPSASESSPSEVPGSPTEPQPSEKKKDRAPERRVSAPSRPRGPRAQNRKAIMDKFGGAASGPTALFRNTKAAGAAIGGVKNMLLEWCRAMTRNYEHVDIQNFSSSWSSGMAFCALIHKFFPEAFDYAELDPAKRRHNFTLAFSTAEKLADCAQLLEVDDMVRLAVPDSKCVYTYIQELYRSLVQKGLVKTKKK
uniprot
proteins
function
FUNCTION: Plays a role in the regulation of contractile properties of both striated and smooth muscles. When unphosphorylated, may inhibit myosin dephosphorylation. Phosphorylation at Ser-301 reduces this inhibitory activity. {ECO:0000269|PubMed:18310078, ECO:0000269|PubMed:20634291}.
uniprot
proteins
mass_dalton
49525
uniprot
proteins
mutagenesis
MUTAGEN 301; /note="S->A: Loss of phosphorylation. Loss of nuclear localization."; /evidence="ECO:0000269|PubMed:15327999, ECO:0000269|PubMed:18310078, ECO:0000269|PubMed:20634291
uniprot
proteins
post_translational_modification
PTM: Maximal phosphorylation of Ser-301 correlates with maximal relaxation of aorta in response to acetylcholine. {ECO:0000269|PubMed:15327999, ECO:0000269|PubMed:18310078, ECO:0000269|PubMed:20634291}.
uniprot
proteins
protein_family
Smoothelin family
uniprot
proteins
pubmed
15327999
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18310078
uniprot
proteins
pubmed
18477568
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20634291
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
459
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, myofibril, sarcomere, M line. Nucleus. Note=Colocalizes with MYH2. In its unphosphorylated state, localizes to the cytoplasm. Phosphorylation at Ser-301 promotes translocation to the nucleus.
uniprot
proteins