Eif3h
entrez
68135
canonical
uniprot
Q91WK2
canonical
ensembl
ENSMUSG00000022312
resolver
ensp
ENSMUSP00000022925
resolver
ensp
ENSMUSP00000178804
resolver
ensp
ENSMUSP00000178805
resolver
ensp
ENSMUSP00000178815
resolver
ensp
ENSMUSP00000340065
resolver
enst
ENSMUST00000022925
resolver
genesymbol
Eif3h
resolver
genesymbol_syn
EIF3H
resolver
genesymbol_syn
EIF3S3
resolver
genesymbol_syn
Eif3s3
resolver
uniprot
Q5M9L0
resolver
uniprot_entry
EIF3H_MOUSE
resolver
uniprot_entry
Q5M9L0_MOUSE
resolver
amino_acid_sequence
MASRKEGTGSTATSSGSAGGAVGKGKGKGGSGDSAVKQVQIDGLVVLKIIKHYQEEGQGTEVVQGVLLGLVVEDRLEITNCFPFPQHTEDDADFDEVQYQMEMMRSLRHVNIDHLHVGWYQSTYYGSFVTRALLDSQFSYQHAIEESVVLIYDPIKTAQGSLSLKAYRLTPKLMEVCKEKDFSPEALKKASITFEHMFEEVPIVIKNSHLINVLMWELEKKSAVADKHELLSLASSNHLGKSLQLLMDRVDEMSQDIIKYNTYMRNTSKQQQQKHQYQQRRQQENMQRQSRGEPPLPEEDLSKLFKPHQAPARMDSLLIAGQINTYCQNIKEFTAQNLGKLFMAQALQEYNN
uniprot
proteins
function
FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. {ECO:0000255|HAMAP-Rule:MF_03007, ECO:0000269|PubMed:17581632}.
uniprot
proteins
mass_dalton
39832
uniprot
proteins
protein_family
EIF-3 subunit H family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17581632
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26100019
uniprot
proteins
sequence_length
352
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03007}.
uniprot
proteins