NABP1
entrez
64859
canonical
uniprot
Q96AH0
canonical
ensembl
ENSG00000173559
resolver
ensp
ENSP00000387243
resolver
ensp
ENSP00000403683
resolver
ensp
ENSP00000646800
resolver
ensp
ENSP00000789174
resolver
genesymbol
NABP1
resolver
genesymbol_syn
OBFC2A
resolver
genesymbol_syn
SSB2
resolver
hgnc
HGNC:26232
resolver
uniprot
Q658Y8
resolver
uniprot
Q9H5X6
resolver
uniprot_entry
SOSB2_HUMAN
resolver
uniprot_sec
Q658Y8
resolver
uniprot_sec
Q9H5X6
resolver
amino_acid_sequence
MNRVNDPLIFIRDIKPGLKNLNVVFIVLEIGRVTKTKDGHEVRSCKVADKTGSITISVWDEIGGLIQPGDIIRLTRGYASMWKGCLTLYTGRGGELQKIGEFCMVYSEVPNFSEPNPDYRGQQNKGAQSEQKNNSMNSNMGTGTFGPVGNGVHTGPESREHQFSHAGRSNGRGLINPQLQGTASNQTVMTTISNGRDPRRAFKR
uniprot
proteins
function
FUNCTION: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. {ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}.
uniprot
proteins
mass_dalton
22423
uniprot
proteins
protein_family
SOSS-B family
uniprot
proteins
protein_family
SOSS-B2 subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19605351
uniprot
proteins
pubmed
19683501
uniprot
proteins
sequence_length
204
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19605351, ECO:0000269|PubMed:19683501}. Note=Localizes to nuclear foci following DNA damage.
uniprot
proteins