Gcgr
entrez
24953
canonical
uniprot
P30082
canonical
ensembl
ENSRNOG00000036692
resolver
ensembl
ENSRNOG00065003924
resolver
ensp
ENSRNOP00000051845
resolver
ensp
ENSRNOP00000107799
resolver
ensp
ENSRNOP00065004149
resolver
enst
ENSRNOT00000153208
resolver
enst
ENSRNOT00065005752
resolver
genesymbol
Gcgr
resolver
uniprot
Q66HT0
resolver
uniprot_entry
GLR_RAT
resolver
uniprot_entry
Q66HT0_RAT
resolver
amino_acid_sequence
MLLTQLHCPYLLLLLVVLSCLPKAPSAQVMDFLFEKWKLYSDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPPNTTANISCPWYLPWYHKVQHRLVFKRCGPDGQWVRGPRGQSWRDASQCQMDDDEIEVQKGVAKMYSSYQVMYTVGYSLSLGALLLALVILLGLRKLHCTRNYIHGNLFASFVLKAGSVLVIDWLLKTRYSQKIGDDLSVSVWLSDGAVAGCRVATVIMQYGIIANYCWLLVEGVYLYSLLSITTFSEKSFFSLYLCIGWGSPLLFVIPWVVVKCLFENVQCWTSNDNMGFWWILRIPVLLAILINFFIFVRIIHLLVAKLRAHQMHYADYKFRLARSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSTKLFFDLFFSSFQGLLVAVLYCFLNKEVQAELLRRWRRWQEGKALQEERMASSHGSHMAPAGTCHGDPCEKLQLMSAGSSSGTGCEPSAKTSLASSLPRLADSPT
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis. Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis. Plays an important role in mediating the responses to fasting. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Promotes activation of adenylate cyclase. Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system. {ECO:0000269|PubMed:8384375}.
uniprot
proteins
mass_dalton
55038
uniprot
proteins
post_translational_modification
PTM: Ligand-binding promotes phosphorylation of serine residues in the C-terminal cytoplasmic domain. Phosphorylation is important for receptor endocytosis after ligand-binding (By similarity). {ECO:0000250|UniProtKB:P47871}.
uniprot
proteins
protein_family
G protein-coupled receptor 2 family
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8082779
uniprot
proteins
pubmed
8384375
uniprot
proteins
pubmed
8384842
uniprot
proteins
sequence_length
485
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8384375}; Multi-pass membrane protein {ECO:0000269|PubMed:8384375}. Note=Is rapidly internalized after ligand-binding. {ECO:0000250|UniProtKB:P47871}.
uniprot
proteins
transmembrane_region
TRANSMEM 138..162; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P47871"; TRANSMEM 175..199; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P47871"; TRANSMEM 227..250; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P47871"; TRANSMEM 265..286; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P47871"; TRANSMEM 305..327; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P47871"; TRANSMEM 352..370; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P47871"; TRANSMEM 383..403; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P47871
uniprot
proteins