Sin3a
entrez
20466
canonical
uniprot
Q60520
canonical
ensembl
ENSMUSG00000042557
resolver
ensp
ENSMUSP00000045044
resolver
ensp
ENSMUSP00000126601
resolver
ensp
ENSMUSP00000128956
resolver
ensp
ENSMUSP00000130221
resolver
ensp
ENSMUSP00000130641
resolver
ensp
ENSMUSP00000243860
resolver
genesymbol
Sin3a
resolver
genesymbol_syn
Kiaa4126
resolver
uniprot
Q570Z7
resolver
uniprot
Q60820
resolver
uniprot
Q62139
resolver
uniprot
Q62140
resolver
uniprot
Q7TPU8
resolver
uniprot
Q7TSZ2
resolver
uniprot_entry
SIN3A_MOUSE
resolver
uniprot_sec
Q570Z7
resolver
uniprot_sec
Q60820
resolver
uniprot_sec
Q62139
resolver
uniprot_sec
Q62140
resolver
uniprot_sec
Q7TPU8
resolver
uniprot_sec
Q7TSZ2
resolver
amino_acid_sequence
MKRRLDDQESPVYAAQQRRIPGSTEAFSHQHRVLAPAPPVYEAVSETMQSATGIQYSVAPNYQVSAVPQSSGSHGPAIAAVHSSHHHPTAVQPHGGQVVQSHAHPAPPVAPVQGQQQFQRLKVEDALSYLDQVKLQFGSQPQVYNDFLDIMKEFKSQSIDTPGVISRVSQLFKGHPDLIMGFNTFLPPGYKIEVQTNDMVNVTTPGQVHQIPTHGIQPQPQPPPQHPSQPSSQSAPTPAQPAPQPTAAKVSKPSQLQAHTPASQQTPPLPPYASPRSPPVQPHTPVTISLGTAPSLQNNQPVEFNHAINYVNKIKNRFQGQPDIYKAFLEILHTYQKEQRNAKEAGGNYTPALTEQEVYAQVARLFKNQEDLLSEFGQFLPDANSSVLLSKTTAEKVDSVRNDHGGTVKKPQLNNKPQRPSQNGCQIRRHSGTGATPPVKKKPKLMSLKESSMADASKHGVGTESLFFDKVRKALRSAEAYENFLRCLVIFNQEVISRAELVQLVSPFLGKFPELFNWFKNFLGYKESVHLESFPKERATEGIAMEIDYASCKRLGSSYRALPKSYQQPKCTGRTPLCKEVLNDTWVSFPSWSEDSTFVSSKKTQYEEHIYRCEDERFELDVVLETNLATIRVLEAIQKKLSRLSAEEQAKFRLDNTLGGTSEVIHRKALQRIYADKAADIIDGLRKNPSIAVPIVLKRLKMKEEEWREAQRGFNKVWREQNEKYYLKSLDHQGINFKQNDTKVLRSKSLLNEIESIYDERQEQATEENAGVPVGPHLSLAYEDKQILEDAAALIIHHVKRQTGIQKEDKYKIKQIMHHFIPDLLFAQRGDLSDVEEEEEEEMDVDEATGAPKKHNGVGGSPPKSKLLFSNTAAQKLRGMDEVYNLFYVNNNWYIFMRLHQILCLRLLRICSQAERQIEEENREREWEREVLGIKRDKSDSPAIQLRLKEPMDVDVEDYYPAFLDMVRSLLDGNIDSSQYEDSLREMFTIHAYIAFTMDKLIQSIVRQLQHIVSDEVCVQVTDLYLAENNNGATGGQLNSQTSRSLLESAYQRKAEQLMSDENCFKLMFIQSQGQVQLTVELLDTEEENSDDPVEAERWSDYVERYMSSDTTSPELREHLAQKPVFLPRNLRRIRKCQRGREQQEKEGKEGNSKKTMENVESLDKLECRFKLNSYKMVYVIKSEDYMYRRTALLRAHQSHERVSKRLHQRFQAWVDKWTKEHVPREMAAETSKWLMGEGLEGLVPCTTTCDTETLHFVSINKYRVKYGTVFKAP
uniprot
proteins
function
FUNCTION: Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (PubMed:22476904). Required for cortical neuron differentiation and callosal axon elongation (PubMed:27399968). {ECO:0000269|PubMed:10734093, ECO:0000269|PubMed:21680841, ECO:0000269|PubMed:22476904, ECO:0000269|PubMed:27399968, ECO:0000269|PubMed:7889570, ECO:0000269|PubMed:8649810}.
uniprot
proteins
mass_dalton
145088
uniprot
proteins
mutagenesis
MUTAGEN 307; /note="A->V: Greatly reduced binding to MAD; when associated with D-308 and A-311."; /evidence="ECO:0000269|PubMed:11106735"; MUTAGEN 308; /note="I->D: Greatly reduced binding to MAD; when associated with V-307 and A-311."; /evidence="ECO:0000269|PubMed:11106735"; MUTAGEN 309; /note="N->D: No effect on binding to MAD."; /evidence="ECO:0000269|PubMed:11106735"; MUTAGEN 311; /note="V->A: Greatly reduced binding to MAD; when associated with V-307 and D-308."; /evidence="ECO:0000269|PubMed:11106735"; MUTAGEN 326; /note="K->A: No effect on binding to MAD."; /evidence="ECO:0000269|PubMed:11106735"; MUTAGEN 329; /note="L->A: Greatly reduced binding to MAD; when associated with A-332."; /evidence="ECO:0000269|PubMed:11106735"; MUTAGEN 332; /note="L->A: Greatly reduced binding to MAD; when associated with A-329."; /evidence="ECO:0000269|PubMed:11106735
uniprot
proteins
post_translational_modification
PTM: SUMO1 sumoylated by TOPORS. Probably desumoylated by SENP2. {ECO:0000250|UniProtKB:Q96ST3}.
uniprot
proteins
pubmed
10734093
uniprot
proteins
pubmed
10950960
uniprot
proteins
pubmed
11106735
uniprot
proteins
pubmed
11390640
uniprot
proteins
pubmed
11882901
uniprot
proteins
pubmed
11909966
uniprot
proteins
pubmed
12130660
uniprot
proteins
pubmed
12198165
uniprot
proteins
pubmed
12398767
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15774581
uniprot
proteins
pubmed
16805913
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144721
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21454521
uniprot
proteins
pubmed
21490601
uniprot
proteins
pubmed
21680841
uniprot
proteins
pubmed
22476904
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
25402684
uniprot
proteins
pubmed
27399968
uniprot
proteins
pubmed
28554894
uniprot
proteins
pubmed
7601471
uniprot
proteins
pubmed
7889570
uniprot
proteins
pubmed
8521822
uniprot
proteins
pubmed
8617250
uniprot
proteins
pubmed
8649810
uniprot
proteins
pubmed
9139820
uniprot
proteins
pubmed
9702189
uniprot
proteins
sequence_length
1274
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21454521}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q96ST3}. Note=Recruited to the nucleolus by SAP30L. {ECO:0000250|UniProtKB:Q96ST3, ECO:0000269|PubMed:21454521}.
uniprot
proteins