Tiprl
entrez
360869
canonical
uniprot
A2VCX1
canonical
ensembl
ENSRNOG00000003048
resolver
ensembl
ENSRNOG00055017821
resolver
ensembl
ENSRNOG00060009696
resolver
ensembl
ENSRNOG00065019530
resolver
ensp
ENSRNOP00000004083
resolver
ensp
ENSRNOP00055024231
resolver
ensp
ENSRNOP00060012799
resolver
ensp
ENSRNOP00065026298
resolver
enst
ENSRNOT00000004083
resolver
enst
ENSRNOT00055030156
resolver
enst
ENSRNOT00060016382
resolver
enst
ENSRNOT00065032904
resolver
genesymbol
Tiprl
resolver
uniprot_entry
TIPRL_RAT
resolver
amino_acid_sequence
MMIHGFQSSHQDFSFGPWKLTASKTHIMKSADVEKLADELHMPSLPEMMFGDNVLRIQHGSGFGIEFNATDALRCVNNYQGMLKVACAEEWQESRTEGEHSKEVIKPYDWTYTTDYKGTLLGESLKLKVVPTTDHIDTEKLKAREQIKFFEEVLLFEDELHDHGVSSLSVKIRVMPSSFFLLLRFFLRIDGVLIRMNDTRLYHEADKTYMLREYTSRESKIANLMHVPPSLFTEPNEISQYLPIKEAVCEKLVFPERIDPNPVDSESAPSE
uniprot
proteins
function
FUNCTION: May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as a negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair (By similarity). {ECO:0000250|UniProtKB:O75663}.
uniprot
proteins
mass_dalton
31225
uniprot
proteins
protein_family
TIP41 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
271
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins