GFRA4
entrez
64096
canonical
uniprot
Q9GZZ7
canonical
ensembl
ENSG00000125861
resolver
ensp
ENSP00000290417
resolver
ensp
ENSP00000313423
resolver
ensp
ENSP00000435801
resolver
genesymbol
GFRA4
resolver
hgnc
HGNC:13821
resolver
uniprot
Q5JT74
resolver
uniprot
Q9H191
resolver
uniprot
Q9H192
resolver
uniprot_entry
GFRA4_HUMAN
resolver
uniprot_sec
Q5JT74
resolver
uniprot_sec
Q9H191
resolver
uniprot_sec
Q9H192
resolver
amino_acid_sequence
MVRCLGPALLLLLLLGSASSVGGNRCVDAAEACTADARCQRLRSEYVAQCLGRAAQGGCPRARCRRALRRFFARGPPALTHALLFCPCAGPACAERRRQTFVPSCAFSGPGPAPPSCLEPLNFCERSRVCRCARAAAGPWRGWGRGLSPAHRPPAAQASPPGLSGLVHPSAQRPRRLPAGPGRPLPARLRGPRGVPAGTAVTPNYVDNVSARVAPWCDCGASGNRREDCEAFRGLFTRNRCLDGAIQAFASGWPPVLLDQLNPQGDPEHSLLQVSSTGRALERRSLLSILPVLALPALL
uniprot
proteins
function
FUNCTION: Receptor for persephin (PSPN), a growth factor that exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons (PubMed:11116144). Acts by binding to its coreceptor, GFRA4, leading to autophosphorylation and activation of the RET receptor (PubMed:11116144). May be important in C-cell development and, in the postnatal development of the adrenal medulla (PubMed:11116144). {ECO:0000269|PubMed:11116144}.
uniprot
proteins
mass_dalton
31670
uniprot
proteins
protein_family
GDNFR family
uniprot
proteins
pubmed
11116144
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
23333276
uniprot
proteins
sequence_length
299
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform GFRalpha4a]: Cell membrane {ECO:0000269|PubMed:11116144}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11116144}.; SUBCELLULAR LOCATION: [Isoform GFRalpha4b]: Cell membrane {ECO:0000269|PubMed:11116144}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:11116144}.; SUBCELLULAR LOCATION: [Isoform GFRalpha4c]: Secreted {ECO:0000269|PubMed:11116144}.
uniprot
proteins