TBC1D3H
entrez
729877
canonical
uniprot
P0C7X1
canonical
ensembl
ENSG00000274226
resolver
ensembl
ENSG00000277974
resolver
ensp
ENSP00000481632
resolver
ensp
ENSP00000482630
resolver
enst
ENST00000610350
resolver
enst
ENST00000619743
resolver
genesymbol
TBC1D3H
resolver
hgnc
HGNC:30708
resolver
uniprot
A6NH17
resolver
uniprot
A8MZ78
resolver
uniprot_entry
TBC3H_HUMAN
resolver
uniprot_sec
A6NH17
resolver
uniprot_sec
A8MZ78
resolver
amino_acid_sequence
MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNTEEMKLKNPGRYQIMKEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKQGDLPPPAKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGAVREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWVRAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQCAPTSGPCLCGLHLESSQFPPGF
uniprot
proteins
function
FUNCTION: Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
62219
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by a CUL7-based E3 ligase, which leads to proteasomal degradation. {ECO:0000250}.; PTM: Palmitoylation is required for membrane localization and protects TBC1D3 from ubiquitination. {ECO:0000250}.
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16863688
uniprot
proteins
pubmed
21030649
uniprot
proteins
sequence_length
549
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Associated with lipid rafts. {ECO:0000250}.
uniprot
proteins