Tnfsf12
entrez
21944
canonical
uniprot
O54907
canonical
ensembl
ENSMUSG00000097328
resolver
ensp
ENSMUSP00000137972
resolver
enst
ENSMUST00000181810
resolver
genesymbol
Tnfsf12
resolver
uniprot
Q5F2A0
resolver
uniprot
Q9CTP2
resolver
uniprot_entry
Q5F2A0_MOUSE
resolver
uniprot_entry
TNF12_MOUSE
resolver
uniprot_sec
Q9CTP2
resolver
amino_acid_sequence
MAARRSQRRRGRRGEPGTALLAPLVLSLGLALACLGLLLVVVSLGSWATLSAQEPSQEELTAEDRREPPELNPQTEESQDVVPFLEQLVRPRRSAPKGRKARPRRAIAAHYEVHPRPGQDGAQAGVDGTVSGWEETKINSSSPLRYDRQIGEFTVIRAGLYYLYCQVHFDEGKAVYLKLDLLVNGVLALRCLEEFSATAASSPGPQLRLCQVSGLLPLRPGSSLRIRTLPWAHLKAAPFLTYFGLFQVH
uniprot
proteins
function
FUNCTION: Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
27441
uniprot
proteins
post_translational_modification
PTM: The soluble form is produced from the membrane form by proteolytic processing. {ECO:0000250}.
uniprot
proteins
protein_family
Tumor necrosis factor family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
9405449
uniprot
proteins
sequence_length
249
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Tumor necrosis factor ligand superfamily member 12, secreted form]: Secreted {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..45; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins