Casp2
entrez
12366
canonical
uniprot
P29594
canonical
ensembl
ENSMUSG00000029863
resolver
ensp
ENSMUSP00000031895
resolver
enst
ENSMUST00000031895
resolver
genesymbol
Casp2
resolver
genesymbol_syn
Ich1
resolver
genesymbol_syn
Nedd-2
resolver
genesymbol_syn
Nedd2
resolver
uniprot
O08737
resolver
uniprot
Q3TCM0
resolver
uniprot
Q8C9H7
resolver
uniprot
Q8K241
resolver
uniprot_entry
CASP2_MOUSE
resolver
uniprot_sec
O08737
resolver
uniprot_sec
Q3TCM0
resolver
uniprot_sec
Q8C9H7
resolver
uniprot_sec
Q8K241
resolver
amino_acid_sequence
MAAPSGRSQSSLHRKGLMAADRRSRILAVCGMHPDHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQAKGGSFSQNVELLNLLPKRGPQAFDAFCEALRETRQGHLEDLLLTTLSDIQHVLPPLSCDYDTSLPFSVCESCPPHKQLRLSTDATEHSLDNGDGPPCLLVKPCTPEFYQAHYQLAYRLQSQPRGLALVLSNVHFTGEKDLEFRSGGDVDHTTLVTLFKLLGYNVHVLHDQTAQEMQEKLQNFAQLPAHRVTDSCVVALLSHGVEGGIYGVDGKLLQLQEVFRLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHTQSPGCEESDAGKEELMKMRLPTRSDMICGYACLKGNAAMRNTKRGSWYIEALTQVFSERACDMHVADMLVKVNALIKEREGYAPGTEFHRCKEMSEYCSTLCQQLYLFPGYPPT
uniprot
proteins
ec_number
3.4.22.55
uniprot
proteins
function
FUNCTION: Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival (PubMed:7958843). Associates with PIDD1 and CRADD to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis in response to genotoxic stress (By similarity). {ECO:0000250|UniProtKB:P42575, ECO:0000269|PubMed:7958843}.
uniprot
proteins
mass_dalton
50661
uniprot
proteins
mutagenesis
MUTAGEN 320; /note="C->G: Loss of function."; /evidence="ECO:0000269|PubMed:7958843
uniprot
proteins
post_translational_modification
PTM: The mature protease can process its own propeptide, but not that of other caspases. {ECO:0000250}.
uniprot
proteins
protein_family
Peptidase C14A family
uniprot
proteins
pubmed
1378265
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7958843
uniprot
proteins
pubmed
9038361
uniprot
proteins
sequence_length
452
uniprot
proteins