Tmem70
entrez
70397
canonical
uniprot
Q921N7
canonical
ensembl
ENSMUSG00000025940
resolver
ensp
ENSMUSP00000070497
resolver
ensp
ENSMUSP00000135483
resolver
enst
ENSMUST00000065373
resolver
enst
ENSMUST00000177501
resolver
genesymbol
Tmem70
resolver
uniprot
A0A0R4J272
resolver
uniprot
Q3TKB6
resolver
uniprot
Q3UAP8
resolver
uniprot
Q9CQY4
resolver
uniprot
Q9D7R8
resolver
uniprot_entry
A0A0R4J272_MOUSE
resolver
uniprot_entry
TMM70_MOUSE
resolver
uniprot_sec
Q3TKB6
resolver
uniprot_sec
Q3UAP8
resolver
uniprot_sec
Q9CQY4
resolver
uniprot_sec
Q9D7R8
resolver
amino_acid_sequence
MLLGLGGRWAAGLWPGRTRTTWCVAAALRGSGIAFWRAASLAEPERLRSGGHLALAESCGPPGRAQIPVCWEQCVRCFHTQVDKPENGRLIYTGNLARTIFGVKCFSYSTSVVSLAFLPYLLSQNNMMFGSLPLQVLFYGVMGSFTVITPTLLHLLTKGYVIRLYHEATSDTYRAVTYNVMLSETSTVFHQDDVTIPESAHIFTSFYAKTKSLLVNPALFLNPEDYNHLMGYDKPFTFDMEEVDEKKLHEGEK
uniprot
proteins
function
FUNCTION: Scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC1 through its interaction (By similarity). Therefore, participates in the early stage of mitochondrial ATP synthase biogenesis and also protects subunit c/ATP5MC1 against intramitochondrial proteolysis (PubMed:28173120, PubMed:31652072). In addition, binds the mitochondrial proton-transporting ATP synthase complexes I and may play a role in the stability of its membrane-bound subassemblies (By similarity). {ECO:0000250|UniProtKB:Q9BUB7, ECO:0000269|PubMed:28173120, ECO:0000269|PubMed:31652072}.
uniprot
proteins
mass_dalton
28275
uniprot
proteins
protein_family
TMEM70 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
28173120
uniprot
proteins
pubmed
31652072
uniprot
proteins
sequence_length
253
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9BUB7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9BUB7}. Note=Mostly located within the inner cristae membrane. {ECO:0000250|UniProtKB:Q9BUB7}.
uniprot
proteins
transmembrane_region
TRANSMEM 100..120; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 136..156; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins