TTLL11
entrez
158135
canonical
uniprot
Q8NHH1
canonical
ensembl
ENSG00000175764
resolver
ensp
ENSP00000321346
resolver
ensp
ENSP00000362881
resolver
ensp
ENSP00000552305
resolver
genesymbol
TTLL11
resolver
genesymbol_syn
C9orf20
resolver
hgnc
HGNC:18113
resolver
uniprot
A0A8I5KQZ2
resolver
uniprot
F8W6M1
resolver
uniprot
Q6ZUZ3
resolver
uniprot_entry
Q6ZUZ3_HUMAN
resolver
uniprot_entry
TTL11_HUMAN
resolver
uniprot_sec
A0A8I5KQZ2
resolver
uniprot_sec
F8W6M1
resolver
amino_acid_sequence
MRRGSSESELAARWEAEAVAAAKAAAKAEAEATAETVAEQVRVDAGAAGEPECKAGEEQPKVLAPAPAQPSAAEEGNTQVLQRPPPTLPPSKPKPVQGLCPHGKPRDKGRSCKRSSGHGSGENGSQRPVTVDSSKARTSLDALKISIRQLKWKEFPFGRRLPCDIYWHGVSFHDNDIFSGQVNKFPGMTEMVRKITLSRAVRTMQNLFPEEYNFYPRSWILPDEFQLFVAQVQMVKDDDPSWKPTFIVKPDGGCQGDGIYLIKDPSDIRLAGTLQSRPAVVQEYICKPLLIDKLKFDIRLYVLLKSLDPLEIYIAKDGLSRFCTEPYQEPTPKNLHRIFMHLTNYSLNIHSGNFIHSDSASTGSKRTFSSILCRLSSKGVDIKKVWSDIISVVIKTVIALTPELKVFYQSDIPTGRPGPTCFQILGFDILLMKNLKPILLEVNANPSMRIEHEHELSPGVFENVPSLVDEEVKVAVIRDTLRLMDPLKKKRENQSQQLEKPFAGKEDALDGELTSAPDCNANPEAHLPSICLKQVFPKYAKQFNYLRLVDRMANLFIRFLGIKGTMKLGPTGFRTFIRSCKLSSSSLSMAAVDILYIDITRRWNSMTLDQRDSGMCLQAFVEAFFFLAQRKFKMLPLHEQVASLIDLCEYHLSLLDEKRLVCGRGVPSGGRPPHRGPPQEPSPSAQPAGDNPPPRTSCANKLSHPRHTLS
uniprot
proteins
ec_number
6.3.2.-
uniprot
proteins
function
FUNCTION: Polyglutamylase which modifies tubulin, generating polyglutamate side chains of variable lengths on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Preferentially mediates ATP-dependent polyglutamate long side-chain elongation over the initiation step of the polyglutamylation reaction. Preferentially modifies the alpha-tubulin tail over a beta-tail (By similarity). Required for CCSAP localization to both spindle and cilia microtubules (PubMed:22493317). Promotes tubulin polyglutamylation which stimulates spastin/SPAST-mediated microtubule severing, thereby regulating microtubule functions (By similarity). {ECO:0000250|UniProtKB:A4Q9F4, ECO:0000269|PubMed:22493317}.
uniprot
proteins
mass_dalton
79091
uniprot
proteins
mutagenesis
MUTAGEN 488..491; /note="KKKR->EEEE: Decreased binding to microtubules and polyglutamylase activity; when associated with E-326 and E-329."; /evidence="ECO:0000269|PubMed:25959773
uniprot
proteins
protein_family
Tubulin--tyrosine ligase family
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
22493317
uniprot
proteins
pubmed
25959773
uniprot
proteins
sequence_length
710
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:A4Q9F4}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A4Q9F4}.
uniprot
proteins