PEAR1
entrez
375033
canonical
uniprot
Q5VY43
canonical
ensembl
ENSG00000187800
resolver
ensp
ENSP00000292357
resolver
ensp
ENSP00000344465
resolver
ensp
ENSP00000528380
resolver
ensp
ENSP00000528381
resolver
ensp
ENSP00000528382
resolver
ensp
ENSP00000528384
resolver
ensp
ENSP00000528385
resolver
enst
ENST00000292357
resolver
enst
ENST00000338302
resolver
enst
ENST00000858321
resolver
enst
ENST00000858323
resolver
enst
ENST00000858325
resolver
enst
ENST00000858326
resolver
genesymbol
PEAR1
resolver
genesymbol_syn
MEGF12
resolver
hgnc
HGNC:33631
resolver
uniprot
Q8TEK2
resolver
uniprot_entry
PEAR1_HUMAN
resolver
uniprot_sec
Q8TEK2
resolver
amino_acid_sequence
MSPPLCPLLLLAVGLRLAGTLNPSDPNTCSFWESFTTTTKESHSRPFSLLPSEPCERPWEGPHTCPQPTVVYRTVYRQVVKTDHRQRLQCCHGFYESRGFCVPLCAQECVHGRCVAPNQCQCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCDPKSGVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGACFCPAERTGPSCDVSCSQGTSGFFCPSTHSCQNGGVFQTPQGSCSCPPGWMGTICSLPCPEGFHGPNCSQECRCHNGGLCDRFTGQCRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDARCFPANGACLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGCQEHCLCLHGGVCQATSGLCQCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQLPCPKGQFGEGCASRCDCDHSDGCDPVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNGGTCLPENGNCVCAPGFRGPSCQRSCQPGRYGKRCVPCKCANHSFCHPSNGTCYCLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDGSCICPLGWTGHHCLEGCPLGTFGANCSQPCQCGPGEKCHPETGACVCPPGHSGAPCRIGIQEPFTVMPTTPVAYNSLGAVIGIAVLGSLVVALVALFIGYRHWQKGKEHHHLAVAYSSGRLDGSEYVMPDVPPSYSHYYSNPSYHTLSQCSPNPPPPNKVPGPLFASLQNPERPGGAQGHDNHTTLPADWKHRREPPPGPLDRGSSRLDRSYSYSYSNGPGPFYNKGLISEEELGASVASLSSENPYATIRDLPSLPGGPRESSYMEMKGPPSGSPPRQPPQFWDSQRRRQPQPQRDSGTYEQPSPLIHDRDSVGSQPPLPPGLPPGHYDSPKNSHIPGHYDLPPVRHPPSPPLRRQDR
uniprot
proteins
function
FUNCTION: Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling (PubMed:36792666). May be involved in the early stages of hematopoiesis (By similarity). {ECO:0000250|UniProtKB:Q8VIK5, ECO:0000269|PubMed:36792666}.
uniprot
proteins
mass_dalton
110666
uniprot
proteins
mutagenesis
MUTAGEN 343; /note="D->N: Reduces interaction with SVEP1."; /evidence="ECO:0000269|PubMed:36792666
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in the intracellular domain on tyrosine residues (PubMed:15851471). Phosphorylated on tyrosine residues by SRC (PubMed:15851471). Tyrosine phosphorylation is detected upon platelet aggregation stimulated by collagen, TRAP and thrombin and platelet-platelet contacts but not after platelet activation (PubMed:15851471). Tyrosine phosphorylation enhanced its association with SHC1 and SHC2 (PubMed:15851471). Phosphorylated when in the presence of SVEP1 (PubMed:36792666). {ECO:0000269|PubMed:15851471, ECO:0000269|PubMed:36792666}.
uniprot
proteins
protein_family
MEGF family
uniprot
proteins
pubmed
15851471
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
36792666
uniprot
proteins
sequence_length
1037
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15851471}; Single-pass membrane protein {ECO:0000255}. Cell projection, lamellipodium {ECO:0000269|PubMed:36792666}. Note=Detected on the cell surface in resting platelets. {ECO:0000269|PubMed:15851471}.
uniprot
proteins
transmembrane_region
TRANSMEM 756..776; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins