Pik3r1
entrez
18708
canonical
uniprot
P26450
canonical
ensembl
ENSMUSG00000041417
resolver
ensp
ENSMUSP00000047004
resolver
ensp
ENSMUSP00000056774
resolver
enst
ENSMUST00000035532
resolver
enst
ENSMUST00000055518
resolver
genesymbol
Pik3r1
resolver
uniprot
F8WJK6
resolver
uniprot
Q3TP23
resolver
uniprot
Q80UI5
resolver
uniprot
Q8C7P2
resolver
uniprot
Q8K3B3
resolver
uniprot_entry
F8WJK6_MOUSE
resolver
uniprot_entry
P85A_MOUSE
resolver
uniprot_entry
Q3TP23_MOUSE
resolver
uniprot_entry
Q80UI5_MOUSE
resolver
uniprot_entry
Q8C7P2_MOUSE
resolver
uniprot_sec
Q8K3B3
resolver
amino_acid_sequence
MSAEGYQYRALYDYKKEREEDIDLHLGDILTVNKGSLVALGFSDGQEARPEDIGWLNGYNETTGERGDFPGTYVEYIGRKRISPPTPKPRPPRPLPVAPGSSKTEADTEQQALPLPDLAEQFAPPDVAPPLLIKLLEAIEKKGLECSTLYRTQSSSNPAELRQLLDCDAASVDLEMIDVHVLADAFKRYLADLPNPVIPVAVYNEMMSLAQELQSPEDCIQLLKKLIRLPNIPHQCWLTLQYLLKHFFKLSQASSKNLLNARVLSEIFSPVLFRFPAASSDNTEHLIKAIEILISTEWNERQPAPALPPKPPKPTTVANNSMNNNMSLQDAEWYWGDISREEVNEKLRDTADGTFLVRDASTKMHGDYTLTLRKGGNNKLIKIFHRDGKYGFSDPLTFNSVVELINHYRNESLAQYNPKLDVKLLYPVSKYQQDQVVKEDNIEAVGKKLHEYNTQFQEKSREYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCQTQERYSKEYIEKFKREGNEKEIQRIMHNHDKLKSRISEIIDSRRRLEEDLKKQAAEYREIDKRMNSIKPDLIQLRKTRDQYLMWLTQKGVRQKKLNEWLGNENTEDQYSLVEDDEDLPHHDEKTWNVGSSNRNKAENLLRGKRDGTFLVRESSKQGCYACSVVVDGEVKHCVINKTATGYGFAEPYNLYSSLKELVLHYQHTSLVQHNDSLNVTLAYPVYAQQRR
uniprot
proteins
function
FUNCTION: Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues (PubMed:27708159). Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (By similarity). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348926). {ECO:0000250, ECO:0000269|PubMed:20348926, ECO:0000269|PubMed:27708159}.
uniprot
proteins
mass_dalton
83517
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated in T-cells by CBLB; which does not promote proteasomal degradation but impairs association with CD28 and CD3Z upon T-cell activation. {ECO:0000269|PubMed:11526404}.; PTM: Phosphorylated. Tyrosine phosphorylated in response to signaling by FGFR1, FGFR2, FGFR3 and FGFR4. Dephosphorylated by PTPRJ. Phosphorylated by PIK3CA at Ser-608; phosphorylation is stimulated by insulin and PDGF. The relevance of phosphorylation by PIK3CA is however unclear. Phosphorylated in response to KIT and KITLG/SCF. Phosphorylated by FGR (By similarity). Phosphorylated by CSF1R. Phosphorylated by ERBB4. Phosphorylated on tyrosine residues by TEK/TIE2. {ECO:0000250, ECO:0000269|PubMed:10353604, ECO:0000269|PubMed:10521483, ECO:0000269|PubMed:11294897, ECO:0000269|PubMed:9312046}.; PTM: In adipose tissue, polyubiquitinated by the BCR(KBTBD2) E3 ubiquitin ligase complex; recognized by KBTBD2 through the SH2 domains, undergoes 'Lys-48'-linked polyubiquitination leading to its degradation. {ECO:0000269|PubMed:27708159}.
uniprot
proteins
protein_family
PI3K p85 subunit family
uniprot
proteins
pubmed
10353604
uniprot
proteins
pubmed
10521483
uniprot
proteins
pubmed
10528161
uniprot
proteins
pubmed
10646608
uniprot
proteins
pubmed
11006284
uniprot
proteins
pubmed
11113178
uniprot
proteins
pubmed
11294897
uniprot
proteins
pubmed
11526404
uniprot
proteins
pubmed
11711534
uniprot
proteins
pubmed
12052866
uniprot
proteins
pubmed
14610044
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16249387
uniprot
proteins
pubmed
1646396
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
1849460
uniprot
proteins
pubmed
19915142
uniprot
proteins
pubmed
20348926
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25328665
uniprot
proteins
pubmed
27708159
uniprot
proteins
pubmed
8128248
uniprot
proteins
pubmed
8943348
uniprot
proteins
pubmed
9312046
uniprot
proteins
sequence_length
724
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P27986}.
uniprot
proteins