Il1r1
entrez
16177
canonical
uniprot
P13504
canonical
ensembl
ENSMUSG00000026072
resolver
ensp
ENSMUSP00000027241
resolver
ensp
ENSMUSP00000110443
resolver
ensp
ENSMUSP00000241279
resolver
ensp
ENSMUSP00000241280
resolver
ensp
ENSMUSP00000241281
resolver
ensp
ENSMUSP00000241282
resolver
ensp
ENSMUSP00000241283
resolver
enst
ENSMUST00000114795
resolver
genesymbol
Il1r1
resolver
genesymbol_syn
Il-1r1
resolver
genesymbol_syn
Il1ra
resolver
uniprot
F7DAU7
resolver
uniprot
Q32MH0
resolver
uniprot
Q8C6P3
resolver
uniprot
Q8C833
resolver
uniprot_entry
F7DAU7_MOUSE
resolver
uniprot_entry
IL1R1_MOUSE
resolver
uniprot_entry
Q32MH0_MOUSE
resolver
uniprot_entry
Q8C6P3_MOUSE
resolver
uniprot_entry
Q8C833_MOUSE
resolver
amino_acid_sequence
MENMKVLLGLICLMVPLLSLEIDVCTEYPNQIVLFLSVNEIDIRKCPLTPNKMHGDTIIWYKNDSKTPISADRDSRIHQQNEHLWFVPAKVEDSGYYYCIVRNSTYCLKTKVTVTVLENDPGLCYSTQATFPQRLHIAGDGSLVCPYVSYFKDENNELPEVQWYKNCKPLLLDNVSFFGVKDKLLVRNVAEEHRGDYICRMSYTFRGKQYPVTRVIQFITIDENKRDRPVILSPRNETIEADPGSMIQLICNVTGQFSDLVYWKWNGSEIEWNDPFLAEDYQFVEHPSTKRKYTLITTLNISEVKSQFYRYPFICVVKNTNIFESAHVQLIYPVPDFKNYLIGGFIILTATIVCCVCIYKVFKVDIVLWYRDSCSGFLPSKASDGKTYDAYILYPKTLGEGSFSDLDTFVFKLLPEVLEGQFGYKLFIYGRDDYVGEDTIEVTNENVKKSRRLIIILVRDMGGFSWLGQSSEEQIAIYNALIQEGIKIVLLELEKIQDYEKMPDSIQFIKQKHGVICWSGDFQERPQSAKTRFWKNLRYQMPAQRRSPLSKHRLLTLDPVRDTKEKLPAATHLPLG
uniprot
proteins
ec_number
3.2.2.6
uniprot
proteins
function
FUNCTION: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Involved in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (By similarity). {ECO:0000250|UniProtKB:P14778}.; FUNCTION: [Isoform 2]: Unable to mediate canonical IL-1 signaling. Cooperates with IL1RAP isoform 3 to mediate IL1B-induced neuronal activity including IL1B-potentiated NMDA-induced calcium influx mediated by Akt kinase activation. {ECO:0000269|PubMed:22778412}.
uniprot
proteins
mass_dalton
66698
uniprot
proteins
mutagenesis
MUTAGEN 134; /note="R->D: Results in impaired interaction with IL1RN."; /evidence="ECO:0000269|PubMed:37315560"; MUTAGEN 134; /note="R->E: Results in impaired interaction with IL1RN."; /evidence="ECO:0000269|PubMed:37315560"; MUTAGEN 134; /note="R->H: No effect on interaction with IL1RN."; /evidence="ECO:0000269|PubMed:37315560"; MUTAGEN 134; /note="R->K: No effect on interaction with IL1RN."; /evidence="ECO:0000269|PubMed:37315560
uniprot
proteins
post_translational_modification
PTM: A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding). {ECO:0000250}.; PTM: Rapidly phosphorylated on Tyr-499 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1. {ECO:0000250}.
uniprot
proteins
protein_family
Interleukin-1 receptor family
uniprot
proteins
pubmed
10854325
uniprot
proteins
pubmed
15062642
uniprot
proteins
pubmed
1828344
uniprot
proteins
pubmed
22778412
uniprot
proteins
pubmed
2969618
uniprot
proteins
pubmed
37315560
uniprot
proteins
pubmed
7775431
uniprot
proteins
sequence_length
576
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Cell membrane {ECO:0000305}. Secreted {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 339..359; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins