SOX13
entrez
9580
canonical
uniprot
Q9UN79
canonical
ensembl
ENSG00000143842
resolver
ensp
ENSP00000356172
resolver
ensp
ENSP00000478239
resolver
ensp
ENSP00000559861
resolver
ensp
ENSP00000559865
resolver
enst
ENST00000367204
resolver
enst
ENST00000618875
resolver
genesymbol
SOX13
resolver
hgnc
HGNC:11192
resolver
uniprot
B4E2B0
resolver
uniprot
O95275
resolver
uniprot
O95826
resolver
uniprot
Q3KQV7
resolver
uniprot
Q5SXX1
resolver
uniprot
Q9UHW7
resolver
uniprot_entry
SOX13_HUMAN
resolver
uniprot_sec
B4E2B0
resolver
uniprot_sec
O95275
resolver
uniprot_sec
O95826
resolver
uniprot_sec
Q3KQV7
resolver
uniprot_sec
Q5SXX1
resolver
uniprot_sec
Q9UHW7
resolver
amino_acid_sequence
MSMRSPISAQLALDGVGTMVNCTIKSEEKKEPCHEAPQGSATAAEPQPGDPARASQDSADPQAPAQGNFRGSWDCSSPEGNGSPEPKRPGVSEAASGSQEKLDFNRNLKEVVPAIEKLLSSDWKERFLGRNSMEAKDVKGTQESLAEKELQLLVMIHQLSTLRDQLLTAHSEQKNMAAMLFEKQQQQMELARQQQEQIAKQQQQLIQQQHKINLLQQQIQQVNMPYVMIPAFPPSHQPLPVTPDSQLALPIQPIPCKPVEYPLQLLHSPPAPVVKRPGAMATHHPLQEPSQPLNLTAKPKAPELPNTSSSPSLKMSSCVPRPPSHGGPTRDLQSSPPSLPLGFLGEGDAVTKAIQDARQLLHSHSGALDGSPNTPFRKDLISLDSSPAKERLEDGCVHPLEEAMLSCDMDGSRHFPESRNSSHIKRPMNAFMVWAKDERRKILQAFPDMHNSSISKILGSRWKSMTNQEKQPYYEEQARLSRQHLEKYPDYKYKPRPKRTCIVEGKRLRVGEYKALMRTRRQDARQSYVIPPQAGQVQMSSSDVLYPRAAGMPLAQPLVEHYVPRSLDPNMPVIVNTCSLREEGEGTDDRHSVADGEMYRYSEDEDSEGEEKSDGELVVLTD
uniprot
proteins
disease_involvement
DISEASE: Note=Autoantibodies against SOX13 are present in sera from patients with type 1 diabetes. {ECO:0000269|PubMed:10871192}.
uniprot
proteins
function
FUNCTION: Transcription factor that binds to DNA at the consensus sequence 5'-AACAAT-3' (PubMed:10871192). Binds to the proximal promoter region of the myelin protein MPZ gene, and may thereby be involved in the differentiation of oligodendroglia in the developing spinal tube (By similarity). Binds to the gene promoter of MBP and acts as a transcriptional repressor (By similarity). Binds to and modifies the activity of TCF7/TCF1, thereby inhibiting transcription and modulates normal gamma-delta T-cell development and differentiation of IL17A expressing gamma-delta T-cells (By similarity). Regulates expression of BLK in the differentiation of IL17A expressing gamma-delta T-cells (By similarity). Promotes brown adipocyte differentiation (By similarity). Inhibitor of WNT signaling (PubMed:20028982). {ECO:0000250|UniProtKB:Q04891, ECO:0000269|PubMed:10871192, ECO:0000269|PubMed:20028982}.
uniprot
proteins
mass_dalton
69228
uniprot
proteins
pubmed
10871192
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17218525
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20028982
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
9421502
uniprot
proteins
sequence_length
622
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}. Cytoplasm {ECO:0000269|PubMed:10871192}.
uniprot
proteins