Rab11b
entrez
79434
canonical
uniprot
O35509
canonical
ensembl
ENSRNOG00000007648
resolver
ensp
ENSRNOP00000010197
resolver
genesymbol
Rab11b
resolver
uniprot
Q9ET14
resolver
uniprot_entry
RB11B_RAT
resolver
uniprot_sec
Q9ET14
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs) which prevent Rab-GDP dissociation. {ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEARAFAEKNNLSFIETSALDSTNVEEAFKNILTEIYRIVSQKQIADRAAHDESPGNNVVDISVPPTTDGQKPNKLQCCQNL
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB11B plays a role in endocytic recycling, regulating apical recycling of several transmembrane proteins including cystic fibrosis transmembrane conductance regulator/CFTR, epithelial sodium channel/ENaC, potassium voltage-gated channel, and voltage-dependent L-type calcium channel. May also regulate constitutive and regulated secretion, like insulin granule exocytosis. Required for melanosome transport and release from melanocytes. Also regulates V-ATPase intracellular transport in response to extracellular acidosis. Promotes Rabin8/RAB3IP preciliary vesicular trafficking to mother centriole by forming a ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, thereby regulating ciliogenesis initiation. On the contrary, upon LPAR1 receptor signaling pathway activation, interaction with phosphorylated WDR44 prevents Rab11-RAB3IP-RAB11FIP3 complex formation and cilia growth. Also interacts with RABL3 to promote ciliary vesicle formation (By similarity). {ECO:0000250|UniProtKB:Q15907, ECO:0000269|PubMed:14627637}.
uniprot
proteins
mass_dalton
24489
uniprot
proteins
post_translational_modification
PTM: Citrullinated by PADI4. {ECO:0000250|UniProtKB:P46638}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
14627637
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
218
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000250|UniProtKB:P46638}; Lipid-anchor {ECO:0000250|UniProtKB:P46638}; Cytoplasmic side {ECO:0000250|UniProtKB:P46638}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000305|PubMed:14627637}; Lipid-anchor {ECO:0000305|PubMed:14627637}; Cytoplasmic side {ECO:0000305|PubMed:14627637}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q15907}; Lipid-anchor {ECO:0000250|UniProtKB:Q15907}; Cytoplasmic side {ECO:0000250|UniProtKB:Q15907}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q15907}. Note=Colocalizes with RAB11AFIP1 on punctate vesicles. {ECO:0000250|UniProtKB:Q15907}.
uniprot
proteins