ELP5
entrez
23587
canonical
uniprot
Q8TE02
canonical
ensembl
ENSG00000170291
resolver
ensembl
ENSG00000288485
resolver
ensp
ENSP00000346412
resolver
ensp
ENSP00000379868
resolver
ensp
ENSP00000379869
resolver
ensp
ENSP00000459835
resolver
ensp
ENSP00000500212
resolver
ensp
ENSP00000500755
resolver
enst
ENST00000672545
resolver
enst
ENST00000673019
resolver
genesymbol
ELP5
resolver
genesymbol_syn
C17orf81
resolver
genesymbol_syn
DERP6
resolver
hgnc
HGNC:30617
resolver
uniprot
A0AAG2TUE2
resolver
uniprot
A8K1M5
resolver
uniprot
D3DTN9
resolver
uniprot
Q659B6
resolver
uniprot
Q7Z2T4
resolver
uniprot
Q8TDR9
resolver
uniprot
Q9BUB2
resolver
uniprot
Q9Y2Q4
resolver
uniprot_entry
A0AAG2TUE2_HUMAN
resolver
uniprot_entry
ELP5_HUMAN
resolver
uniprot_sec
A8K1M5
resolver
uniprot_sec
D3DTN9
resolver
uniprot_sec
Q659B6
resolver
uniprot_sec
Q7Z2T4
resolver
uniprot_sec
Q8TDR9
resolver
uniprot_sec
Q9BUB2
resolver
uniprot_sec
Q9Y2Q4
resolver
amino_acid_sequence
MLDSLLALGGLVLLRDSVEWEGRSLLKALVKKSALCGEQVHILGCEVSEEEFREGFDSDINNRLVYHDFFRDPLNWSKTEEAFPGGPLGALRAMCKRTDPVPVTIALDSLSWLLLRLPCTTLCQVLHAVSHQDSCPGDSSSVGKVSVLGLLHEELHGPGPVGALSSLAQTEVTLGGTMGQASAHILCRRPRQRPTDQTQWFSILPDFSLDLQEGPSVESQPYSDPHIPPVDPTTHLTFNLHLSKKEREARDSLILPFQFSSEKQQALLRPRPGQATSHIFYEPDAYDDLDQEDPDDDLDI
uniprot
proteins
function
FUNCTION: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244). Involved in cell migration (By similarity). {ECO:0000250|UniProtKB:Q99L85, ECO:0000303|PubMed:29332244}.
uniprot
proteins
mass_dalton
33197
uniprot
proteins
pathway_participation
PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. {ECO:0000303|PubMed:29332244}.
uniprot
proteins
post_translational_modification
PTM: Tyrosine-phosphorylated. {ECO:0000269|PubMed:31341009}.
uniprot
proteins
protein_family
ELP5 family
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16850183
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
22854966
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
29332244
uniprot
proteins
pubmed
31341009
uniprot
proteins
sequence_length
300
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22854966}. Cytoplasm {ECO:0000269|PubMed:16850183, ECO:0000269|PubMed:22854966}.
uniprot
proteins