Ptpn6
entrez
116689
canonical
uniprot
P81718
canonical
ensembl
ENSRNOG00000014294
resolver
ensp
ENSRNOP00000059867
resolver
ensp
ENSRNOP00000071320
resolver
enst
ENSRNOT00000065416
resolver
enst
ENSRNOT00000082739
resolver
genesymbol
Ptpn6
resolver
genesymbol_syn
Ptph6
resolver
uniprot
A0A0G2K064
resolver
uniprot
A0ACM8Q8C5
resolver
uniprot
G3V9T9
resolver
uniprot
Q499N7
resolver
uniprot_entry
A0A0G2K064_RAT
resolver
uniprot_entry
A0ACM8Q8C5_RAT
resolver
uniprot_entry
PTN6_RAT
resolver
uniprot_entry
Q499N7_RAT
resolver
uniprot_sec
G3V9T9
resolver
amino_acid_sequence
MLSRGWFHRDLSGPDAETLLKGRGVPGSFLARPSRKNQGDFSLSVRVDDQVTHIRIQNSGDFYDLYGGEKFATSTELVEYYTQQQGILQDRDGTIIHLKYPLNCSDPTSERWYHGHMSGGQAESLLQAKGEPWTFLVRESLSQPGDFVLSVLNDQPKAAPGSPLRVTHIKVMCEGGRYTVGGSETFDSLTDLVEHFKKTGIEEASGAFVYLRQPYYATRVNAADIENRVLELNKKQESEDTAKAGFWEEFESLQKQEAKNLHQRLEGQRPENKSKNRYKNILPFDHSRVILQGRDSNIPGSDYINANYVKNQLLGPDENSKTYIASQGCLDATVNDFWQMAWQENTRVIVMTTREVEKGRNKCVPYWPEVGTQRVYGLYSVTNCKEHDTAEYKLRTLQISPLDNGDLVREIWHYQYLSWPDHGVPSEPGGVLSFLDQINQRQESLPHAGPIIVHCSAGIGRTGTIIVIDMLMESVSTKGLDCDIDIQKTIQMVRAQRSGMVQTEAQYKFIYVAIAQFIETTKKKLEIIQSQRGQESEYGNITYPPALRSAHAKASRTSSKHKEEVYENVHSKNKKEEKVKKQRSADKEKNKGSLKRNISLTPCRGLRWADRDL
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Tyrosine phosphatase enzyme that plays important roles in controlling immune signaling pathways and fundamental physiological processes such as hematopoiesis. Dephosphorylates and negatively regulate several receptor tyrosine kinases (RTKs) such as EGFR, PDGFR and FGFR, thereby modulating their signaling activities. When recruited to immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing receptors such as immunoglobulin-like transcript 2/LILRB1, programmed cell death protein 1/PDCD1, CD3D, CD22, CLEC12A and other receptors involved in immune regulation, initiates their dephosphorylation and subsequently inhibits downstream signaling events. Modulates the signaling of several cytokine receptors including IL-4 receptor. Additionally, targets multiple cytoplasmic signaling molecules including STING1, LCK or STAT1 among others involved in diverse cellular processes including modulation of T-cell activation or cGAS-STING signaling. Within the nucleus, negatively regulates the activity of some transcription factors such as NFAT5 via direct dephosphorylation. Also acts as a key transcriptional regulator of hepatic gluconeogenesis by controlling recruitment of RNA polymerase II to the PCK1 promoter together with STAT5A. {ECO:0000250|UniProtKB:P29350, ECO:0000269|PubMed:17068200}.
uniprot
proteins
mass_dalton
69578
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues. Binding of KITLG/SCF to KIT increases tyrosine phosphorylation (By similarity). Phosphorylation at Tyr-566 by LYN enhances phosphatase activity. Phosphorylation at Thr-396 by TAOK3 leads to polyubiquitination and subsequent proteasomal degradation (By similarity). {ECO:0000250|UniProtKB:P29350, ECO:0000250|UniProtKB:P29351}.; PTM: Ubiquitinated after phosphorylation by TAOK3. Ubiquitinated by a cooperation between ITCH and WWP2 via 'Lys-27'-mediated polyubiquitin chains resulting in the reduction of its association with LCK. {ECO:0000250|UniProtKB:P29350}.
uniprot
proteins
protein_family
Non-receptor class 2 subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
17068200
uniprot
proteins
pubmed
18713988
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
613
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17068200}. Nucleus {ECO:0000269|PubMed:17068200}. Note=In neurons, translocates into the nucleus after treatment with angiotensin II. Shuttles between the cytoplasm and nucleus via its association with PDPK (By similarity). {ECO:0000250}.
uniprot
proteins