IFT88
entrez
8100
canonical
uniprot
Q13099
canonical
ensembl
ENSG00000032742
resolver
ensp
ENSP00000261632
resolver
ensp
ENSP00000323580
resolver
ensp
ENSP00000564297
resolver
ensp
ENSP00000564298
resolver
ensp
ENSP00000564299
resolver
ensp
ENSP00000564300
resolver
ensp
ENSP00000564308
resolver
ensp
ENSP00000564312
resolver
ensp
ENSP00000564317
resolver
ensp
ENSP00000564318
resolver
ensp
ENSP00000564320
resolver
ensp
ENSP00000620159
resolver
ensp
ENSP00000620162
resolver
ensp
ENSP00000620163
resolver
ensp
ENSP00000620174
resolver
ensp
ENSP00000675961
resolver
ensp
ENSP00000719144
resolver
ensp
ENSP00000719146
resolver
ensp
ENSP00000719147
resolver
genesymbol
IFT88
resolver
genesymbol_syn
TG737
resolver
genesymbol_syn
TTC10
resolver
hgnc
HGNC:20606
resolver
uniprot
A0A140VJL7
resolver
uniprot
A2A491
resolver
uniprot
B3KX42
resolver
uniprot
B4DUS2
resolver
uniprot
Q5SZJ6
resolver
uniprot
Q8N719
resolver
uniprot_entry
A0A140VJL7_HUMAN
resolver
uniprot_entry
B3KX42_HUMAN
resolver
uniprot_entry
IFT88_HUMAN
resolver
uniprot_sec
A2A491
resolver
uniprot_sec
B4DUS2
resolver
uniprot_sec
Q5SZJ6
resolver
uniprot_sec
Q8N719
resolver
amino_acid_sequence
MMQNVHLAPETDEDDLYSGYNDYNPIYDIEELENDAAFQQAVRTSHGRRPPITAKISSTAVTRPIATGYGSKTSLASSIGRPMTGAIQDGVTRPMTAVRAAGFTKAALRGSAFDPLSQSRGPASPLEAKKKDSPEEKIKQLEKEVNELVEESCIANSCGDLKLALEKAKDAGRKERVLVRQREQVTTPENINLDLTYSVLFNLASQYSVNEMYAEALNTYQVIVKNKMFSNAGILKMNMGNIYLKQRNYSKAIKFYRMALDQVPSVNKQMRIKIMQNIGVTFIQAGQYSDAINSYEHIMSMAPNLKAGYNLTICYFAIGDREKMKKAFQKLITVPLEIDEDKYISPSDDPHTNLVTEAIKNDHLRQMERERKAMAEKYIMTSAKLIAPVIETSFAAGYDWCVEVVKASQYVELANDLEINKAVTYLRQKDYNQAVEILKVLEKKDSRVKSAAATNLSALYYMGKDFAQASSYADIAVNSDRYNPAALTNKGNTVFANGDYEKAAEFYKEALRNDSSCTEALYNIGLTYEKLNRLDEALDCFLKLHAILRNSAEVLYQIANIYELMENPSQAIEWLMQVVSVIPTDPQVLSKLGELYDREGDKSQAFQYYYESYRYFPCNIEVIEWLGAYYIDTQFWEKAIQYFERASLIQPTQVKWQLMVASCFRRSGNYQKALDTYKDTHRKFPENVECLRFLVRLCTDLGLKDAQEYARKLKRLEKMKEIREQRIKSGRDGSGGSRGKREGSASGDSGQNYSASSKGERLSARLRALPGTNEPYESSSNKEIDASYVDPLGPQIERPKTAAKKRIDEDDFADEELGDDLLPE
uniprot
proteins
function
FUNCTION: Positively regulates primary cilium biogenesis (PubMed:17604723). Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment. {ECO:0000250|UniProtKB:Q61371, ECO:0000269|PubMed:17604723}.
uniprot
proteins
mass_dalton
93192
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17604723
uniprot
proteins
pubmed
27767179
uniprot
proteins
pubmed
28428259
uniprot
proteins
pubmed
28625565
uniprot
proteins
pubmed
30388400
uniprot
proteins
pubmed
36606424
uniprot
proteins
pubmed
7633404
uniprot
proteins
sequence_length
824
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q61371}. Cell projection, cilium {ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:28428259}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:17604723, ECO:0000269|PubMed:27767179, ECO:0000269|PubMed:28428259, ECO:0000269|PubMed:28625565, ECO:0000269|PubMed:36606424}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:27767179}. Cytoplasm {ECO:0000250|UniProtKB:Q61371}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q61371}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q61371}. Note=Colocalizes with ENTR1 and gamma-tubulin at the basal body of primary cilia (PubMed:27767179). Colocalizes with ENTR1 and pericentrin at the centrosome (PubMed:27767179). In sperm cells, localizes to the manchette, head-tail coupling apparatus and flagellum. Localizes to the manchette in elongating spermatids in a CFAP70-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q61371, ECO:0000269|PubMed:27767179}.
uniprot
proteins