F8a1
entrez
501661
canonical
uniprot
M0RDU0
canonical
ensembl
ENSRNOG00000080664
resolver
ensembl
ENSRNOG00000085632
resolver
ensembl
ENSRNOG00055025503
resolver
ensembl
ENSRNOG00060006841
resolver
ensembl
ENSRNOG00060020412
resolver
ensembl
ENSRNOG00065015354
resolver
ensembl
ENSRNOG00065015359
resolver
ensp
ENSRNOP00000102301
resolver
ensp
ENSRNOP00000105572
resolver
ensp
ENSRNOP00055035989
resolver
ensp
ENSRNOP00060008356
resolver
ensp
ENSRNOP00060029043
resolver
ensp
ENSRNOP00065019975
resolver
ensp
ENSRNOP00065019979
resolver
enst
ENSRNOT00000142215
resolver
enst
ENSRNOT00000169584
resolver
enst
ENSRNOT00055044005
resolver
enst
ENSRNOT00060011189
resolver
enst
ENSRNOT00060035334
resolver
enst
ENSRNOT00065025454
resolver
enst
ENSRNOT00065025458
resolver
genesymbol
F8a1
resolver
genesymbol_syn
F8a
resolver
genesymbol_syn
Hap40
resolver
uniprot_entry
HAP40_RAT
resolver
amino_acid_sequence
MAAGSASSLGGGSWPGSEAGDFLARYRQVSNKLKKRFLRKPNVAEAGEQFAQLARELRAQECLPYAAWCQLAVARCQQALFHGPGEALALTEAARLFLRQECDARQRLGCPAAYGEPLQAAASALGAAVRLHLELGQPAAAAALCLELAAALRAVGQPAAAAGHFQRAAQLHLPLMPLAALQALGDAASCQLLARDYTGALAVFTRMQRLAREHGGHPVQQPELPQQLPSVPQPSLPGPQPRPVLGSTLPLPLPPDHAPGSVAQSPGTLGAFADVLVRCEVSRVLLLLLLQPPPAKLLPEHAQTLEKYSWEAFDGHGQDSSGQLPEELFLLLQSLVMAAHEKDTEGIKKLQVEMWPLLTAEQNHLLHLVLQETISPSGQGV
uniprot
proteins
function
FUNCTION: RAB5A effector molecule that is involved in vesicular trafficking of early endosomes. Mediates the recruitment of HTT by RAB5A onto early endosomes. The HTT-F8A1/F8A2/F8A3-RAB5A complex stimulates early endosomal interaction with actin filaments and inhibits interaction with microtubules, leading to the reduction of endosome motility. {ECO:0000269|PubMed:16476778}.
uniprot
proteins
mass_dalton
40544
uniprot
proteins
pubmed
11035034
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
16476778
uniprot
proteins
sequence_length
381
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P23610}. Nucleus {ECO:0000250|UniProtKB:P23610}. Early endosome {ECO:0000250|UniProtKB:P23610}. Nucleus, nuclear body {ECO:0000250|UniProtKB:Q00558}. Note=Diffuse presence in the cytoplasm and accumulation in the nucleus (By similarity). In absence of HTT, F8A1/F8A2/F8A3 is concentred in cytoplasm (By similarity). Colocalized with HTT in endosomes (By similarity). In neuron found in intranuclear structures, the intranuclear rodlets (INRs), also known as rodlets of Roncoroni, in association with ubiquitin (By similarity). {ECO:0000250|UniProtKB:P23610, ECO:0000250|UniProtKB:Q00558}.
uniprot
proteins