Smug1
entrez
71726
canonical
uniprot
Q6P5C5
canonical
ensembl
ENSMUSG00000036061
resolver
ensp
ENSMUSP00000065835
resolver
ensp
ENSMUSP00000155594
resolver
ensp
ENSMUSP00000155700
resolver
ensp
ENSMUSP00000166018
resolver
ensp
ENSMUSP00000166019
resolver
ensp
ENSMUSP00000166020
resolver
ensp
ENSMUSP00000166023
resolver
enst
ENSMUST00000064067
resolver
enst
ENSMUST00000229371
resolver
enst
ENSMUST00000229377
resolver
genesymbol
Smug1
resolver
uniprot
Q9DBV1
resolver
uniprot_entry
SMUG1_MOUSE
resolver
uniprot_sec
Q9DBV1
resolver
amino_acid_sequence
MAASQTFPLGPTHEPASALMEPLPCTRSLAEGFLEEELRLNAELSQLQFPEPVGVIYNPVDYAWEPHRNYVTRYCQGPKEVLFLGMNPGPFGMAQTGVPFGEVNVVRDWLGVGGPVLTPPQEHPKRPVLGLECPQSEVSGARFWGFFRTLCGQPQVFFRHCFVHNLCPLLFLAPSGRNLTPAELPAKQREQLLSICDAALCRQVQLLGVRLVVGVGRLAEQRARRALAGLTPEVQVEGLLHPSPRSAQANKGWEAAARERLQELGLLPLLTDEGSARPT
uniprot
proteins
ec_number
3.2.2.-
uniprot
proteins
function
FUNCTION: Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration. {ECO:0000250|UniProtKB:Q53HV7}.
uniprot
proteins
mass_dalton
30654
uniprot
proteins
protein_family
SMUG1 family
uniprot
proteins
protein_family
Uracil-DNA glycosylase (UDG) superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
279
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q53HV7}.
uniprot
proteins