Tut7
entrez
214290
canonical
uniprot
Q5BLK4
canonical
ensembl
ENSMUSG00000035248
resolver
ensp
ENSMUSP00000071623
resolver
ensp
ENSMUSP00000230924
resolver
ensp
ENSMUSP00000230925
resolver
ensp
ENSMUSP00000230926
resolver
ensp
ENSMUSP00000230935
resolver
enst
ENSMUST00000071703
resolver
genesymbol
Tut7
resolver
genesymbol_syn
Kiaa1711
resolver
genesymbol_syn
Zcchc6
resolver
uniprot
A1A4B1
resolver
uniprot
E9PUA2
resolver
uniprot
Q3V3V7
resolver
uniprot
Q8CIH3
resolver
uniprot_entry
E9PUA2_MOUSE
resolver
uniprot_entry
TUT7_MOUSE
resolver
uniprot_sec
A1A4B1
resolver
uniprot_sec
Q3V3V7
resolver
uniprot_sec
Q8CIH3
resolver
amino_acid_sequence
MGDTAKPYFVKRTKDRGIIDDDDFRRGHPQQDYLIMDDYAKGHSSKMEKGLPKKKISPGNYGNTPRKGLYGVSSNPYAFKNPIYSQPAWMNDNHKDQNKKWLSDELAGNADSWREFKPGPRIPVISRSRKESFQESDDAYRWQEGRGCRAVRRLFQKDLSSLEAMSEMEAGSPENKKQRSRPRKPRRTRTEDSEQDGDLDGPVIDESVLSTKELLGLQQAEERLKRDCIDRLKRRPRNCPTAKYTCKLCDALIDSIPFAHKHIKEKRHKKNLKEKQEEELLTTLPPPAPSQIHAVGSAIDRVVQEFGLHSENLDQRLEIKRVMESVFRHKLPDCSLRLYGSSCSRLGFRDSDVNIDVQFPAVMSQPDVLLLVQECLKNSDSFIDVDADFHARVPVVVCRDKQSGLLCKVSAGNENAWLTTKHLTALGKLEPRLVPLVIAFRYWAKLCSIDRPEEGGLPPYVFALMAVFFLQQRKEPLLPVYLGSWIEEFSLNKLGNFSLKDVEKDSVVWEYTDNSTGDTSSAKEEAPKETAAKKGQVPLTFNIKHQPSVPVGQLWVELLRFYALEFNLADLVISIRVKELISRESKDWPKKRIAIEDPYSVKRNVARTLNNQPVFEYILHCLRTTYKYFALPHKVTKPNLTKPPSPVTCVSDPYREAKNGGPEPQATNIDKLGNAAVAQDPGVQTSGDCRAQLVTLKNTTEEVGSPAKEKTGGVHIPAHQESSGCVQAEVSCEGLEDATAELPETGSDNEEVRRKTKHPLSTDDQGLSSSKHPELQNCGSLCGLQADNTLELVAEECNSCASLDNKAEVNEERIEGAEELEEAAALSCFSPSVQSRTSAAMHFDDEEEEEEEEEEEEPRLSINLTEDEEGVANEHQVDSRYAGSGEEDALSEEDDLAEPAKGEDTGECGENVGGTLLIDLNRITLKEESFPEEDLPGDQSEFFYEFRKLTFTKGKSPTVVCSLCKREGHLKKDCPEDFKRVQLEPLPPLTPKFSNILDQVCVQCYKDFSPTIVEDQAREHIRQNLESFIKQDFPGTKLSLFGSSKNGFGFKQSDLDVCMTINGHETAEGLDCVRTIEELARVLRKHSGLRNILPITTAKVPIVKFFHLRSGLEVDISLYNTLALHNTRLLSAYSAIDPRVKYLCYTMKVFTKMCDIGDASRGSLSSYAYTLMVLYFLQQRSPPVIPVLQEIYKGEKKPEILVDGWNIYFFDQINELPTCWPEYGKNTEPVGQLWLGLLRFYTEEFDFKEHVISIRRKSLLTTFKKQWTSKYIVIEDPFDLNHNLGAGLSRKMTNFIMKAFINGRRVFGIPVKGFPKDNPSKLAYFFDPDVLTEGELAPNDRCCRICGKIGHFMKDCPMRRKVRRRRDQEDTPNQRYSESKEKRSKEDKEIQNKYTEKEVSTKEDKLTPCAAAKAKPVRAAVDLGREKLLRTPTEKWKRQDDRDSREKRCFICGREGHIKKECPQFKGSPGSLSSKYMTQGRASVKRTQQES
uniprot
proteins
ec_number
2.7.7.52
uniprot
proteins
function
FUNCTION: Uridylyltransferase that mediates the terminal uridylation of mRNAs with short (less than 25 nucleotides) poly(A) tails, hence facilitating global mRNA decay (PubMed:28792939). Essential for both oocyte maturation and fertility. Through 3' terminal uridylation of mRNA, sculpts, with TUT7, the maternal transcriptome by eliminating transcripts during oocyte growth (PubMed:28792939). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets. Also acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of miRNA precursors, including that of let-7 (pre-let-7) (PubMed:22898984). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 uridylation is strongly enhanced in the presence of LIN28A. Due to functional redundancy between ZCCHC6 and ZCCHC11, the identification of the specific role of each of these proteins is difficult (By similarity) (PubMed:22898984). Involved in microRNA (miRNA)-induced gene silencing through uridylation of deadenylated miRNA targets (By similarity). Also functions as an integral regulator of microRNA biogenesiS using 3 different uridylation mechanisms (By similarity). Acts as a suppressor of miRNA biogenesis by mediating the terminal uridylation of some miRNA precursors, including that of let-7 (pre-let-7). Uridylated pre-let-7 RNA is not processed by Dicer and undergo degradation. Pre-let-7 oligouridylation is strongly enhanced in the presence of LIN28A (PubMed:22898984). In the absence of LIN28A, TUT7 and TUT4 monouridylate group II pre-miRNAs, which includes most of pre-let7 members, that shapes an optimal 3' end overhang for efficient processing (By similarity). Add oligo-U tails to truncated pre-miRNAS with a 5' overhang which may promote rapid degradation of non-functional pre-miRNA species (By similarity). Does not play a role in replication-dependent histone mRNA degradation (By similarity). Due to functional redundancy between TUT4 and TUT7, the identification of the specific role of each of these proteins is difficult (PubMed:22898984, PubMed:28792939). TUT4 and TUT7 restrict retrotransposition of long interspersed element-1 (LINE-1) in cooperation with MOV10 counteracting the RNA chaperonne activity of L1RE1. TUT7 uridylates LINE-1 mRNAs in the cytoplasm which inhibits initiation of reverse transcription once in the nucleus, whereas uridylation by TUT4 destabilizes mRNAs in cytoplasmic ribonucleoprotein granules (By similarity). {ECO:0000250|UniProtKB:Q5VYS8, ECO:0000269|PubMed:22898984, ECO:0000269|PubMed:28792939}.
uniprot
proteins
mass_dalton
169103
uniprot
proteins
protein_family
DNA polymerase type-B-like family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22898984
uniprot
proteins
pubmed
28792939
uniprot
proteins
sequence_length
1491
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5VYS8}.
uniprot
proteins