Lin7c
entrez
22343
canonical
uniprot
O88952
canonical
ensembl
ENSMUSG00000027162
resolver
ensp
ENSMUSP00000028583
resolver
enst
ENSMUST00000028583
resolver
genesymbol
Lin7c
resolver
genesymbol_syn
Mals3
resolver
genesymbol_syn
Veli3
resolver
uniprot_entry
LIN7C_MOUSE
resolver
amino_acid_sequence
MAALGEPVRLERDICRAIELLEKLQRSGEVPPQKLQALQRVLQSEFCNAVREVYEHVYETVDISSSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVVRYTPKVLEEMESRFEKMRSAKRRQQT
uniprot
proteins
function
FUNCTION: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (PubMed:10846156). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. {ECO:0000269|PubMed:10846156}.
uniprot
proteins
mass_dalton
21834
uniprot
proteins
protein_family
Lin-7 family
uniprot
proteins
pubmed
10341223
uniprot
proteins
pubmed
10710551
uniprot
proteins
pubmed
10753959
uniprot
proteins
pubmed
10846156
uniprot
proteins
pubmed
15466885
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15494546
uniprot
proteins
pubmed
15878399
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9753324
uniprot
proteins
sequence_length
197
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Basolateral cell membrane; Peripheral membrane protein. Cell junction. Postsynaptic density membrane; Peripheral membrane protein. Cell junction, tight junction. Note=Mainly basolateral in renal epithelial cells.
uniprot
proteins