AHRR
entrez
57491
canonical
uniprot
A9YTQ3
canonical
ensembl
ENSG00000063438
resolver
ensp
ENSP00000323816
resolver
ensp
ENSP00000507476
resolver
genesymbol
AHRR
resolver
genesymbol_syn
BHLHE77
resolver
genesymbol_syn
KIAA1234
resolver
hgnc
HGNC:346
resolver
uniprot
A0A7I2PK40
resolver
uniprot
A7MBN5
resolver
uniprot
D6RAZ1
resolver
uniprot
Q9HAZ3
resolver
uniprot
Q9ULI6
resolver
uniprot_entry
AHRR_HUMAN
resolver
uniprot_sec
A0A7I2PK40
resolver
uniprot_sec
A7MBN5
resolver
uniprot_sec
D6RAZ1
resolver
uniprot_sec
Q9HAZ3
resolver
uniprot_sec
Q9ULI6
resolver
amino_acid_sequence
MIPPGECTYAGRKRRRPLQKQRPAVGAEKSNPSKRHRDRLNAELDHLASLLPFPPDIISKLDKLSVLRLSVSYLRVKSFFQVVQEQSSRQPAAGAPSPGDSCPLAGSAVLEGRLLLESLNGFALVVSAEGTIFYASATIVDYLGFHQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQPPPLETGDDAILGRLLRAQEWGTGTPTEYSAFLTRCFICRVRCLLDSTSGFLTMQFQGKLKFLFGQKKKAPSGAMLPPRLSLFCIAAPVLLPSAAEMKMRSALLRAKPRADTAATADAKVKATTSLCESELHGKPNYSAGRSSRESGVLVLREQTDAGRWAQVPARAPCLCLRGGPDLVLDPKGGSGDREEEQHRMLSRASGVTGRRETPGPTKPLPWTAGKHSEDGARPRLQPSKNDPPSLRPMPRGSCLPCPCVQGTFRNSPISHPPSPSPSAYSSRTSRPMRDVGEDQVHPPLCHFPQRSLQHQLPQPGAQRFATRGYPMEDMKLQGVPMPPGDLCGPTLLLDVSIKMEKDSGCEGAADGCVPSQVWLGASDRSHPATFPTRMHLKTEPDSRQQVYISHLGHGVRGAQPHGRATAGRSRELTPFHPAHCACLEPTDGLPQSEPPHQLCARGRGEQSCTCRAAEAAPVVKREPLDSPQWATHSQGMVPGMLPKSALATLVPPQASGCTFLP
uniprot
proteins
function
FUNCTION: Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with AHR for heterodimer formation with ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of a variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site. {ECO:0000269|PubMed:17890447, ECO:0000269|PubMed:18172554}.; FUNCTION: [Isoform 1]: Represses AHR transcription activity (PubMed:19380484). Also represses transcription mediated by HIF1A and EPAS1/HIF2A but does not repress NR1I2/PXR or ESR1 transcriptional activities (PubMed:19380484). {ECO:0000269|PubMed:19380484}.; FUNCTION: [Isoform 2]: Does not repress AHR transcription activity. {ECO:0000269|PubMed:19380484}.
uniprot
proteins
mass_dalton
75780
uniprot
proteins
pubmed
10574462
uniprot
proteins
pubmed
11835227
uniprot
proteins
pubmed
14672759
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15474075
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16084889
uniprot
proteins
pubmed
17559847
uniprot
proteins
pubmed
17890447
uniprot
proteins
pubmed
17980155
uniprot
proteins
pubmed
18172554
uniprot
proteins
pubmed
19380484
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28904176
uniprot
proteins
sequence_length
697
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17980155}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:17980155}. Note=Predominantly in the nuclear compartment. First cytoplasmic, translocates into the nuclear compartment upon interaction with ARNT in the cytoplasmic compartment.
uniprot
proteins