Mvp
entrez
64681
canonical
uniprot
Q62667
canonical
ensembl
ENSRNOG00000020182
resolver
ensp
ENSRNOP00000089790
resolver
genesymbol
Mvp
resolver
uniprot_entry
MVP_RAT
resolver
amino_acid_sequence
MATEEAIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPVRMVTVPPRHYCIVANPVSRDTQSSVLFDITGQVRLRHADQEIRLAQDPFPLYPGEVLEKDITPLQVVLPNTALHLKALLDFEDKNGDKVMAGDEWLFEGPGTYIPQKEVEVVEIIQATVIKQNQALRLRARKECFDREGKGRVTGEEWLVRSVGAYLPAVFEEVLDLVDAVILTEKTALHLRALQNFRDLRGVLHRTGEEWLVTVQDTEAHVPDVYEEVLGVVPITTLGPRHYCVILDPMGPDGKNQLGQKRVVKGEKSFFLQPGERLERGIQDVYVLSEQQGLLLKALQPLEEGESEEKVSHQAGDCWLIRGPLEYVPSAKVEVVEERQAIPLDQNEGIYVQDVKTGKVRAVIGSTYMLTQDEVLWEKELPSGVEELLNLGHDPLADRGQKGTAKPLQPSAPRNKTRVVSYRVPHNAAVQVYDYRAKRARVVFGPELVTLDPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFFTDVITIETADHARLQLQLAYNWHFELKNRNDPAEAAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRMAVFGFEMSEDTGPDGTLLPKARDQAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEAMSMAVESTGNAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELERVKKVREMELIYARAQLELEVSKAQQLANVEAKKFKEMTEALGPGTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSSPINLFSTAFGLLGLGSDGQPPAQK
uniprot
proteins
function
FUNCTION: Structural component of the vault particle, which is a massive ribonucleoprotein complex that may play a role in cargo transport and signal transduction (By similarity). Oligomerizes to form a cage-like vault complex, which can house several minor vault components including PARP4 (By similarity). Vaults may play a role in nucleo-cytoplasmic transport (By similarity). Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK (By similarity). Down-regulates SRC activity and signaling through MAP kinases (By similarity). {ECO:0000250|UniProtKB:Q14764}.
uniprot
proteins
mass_dalton
95798
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Tyr residues after EGF stimulation (By similarity). {ECO:0000250|UniProtKB:Q14764}.; PTM: Dephosphorylated by PTPN11 (By similarity). {ECO:0000250|UniProtKB:Q14764}.
uniprot
proteins
protein_family
Major vault protein family
uniprot
proteins
pubmed
10551828
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18044992
uniprot
proteins
pubmed
19150846
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7828886
uniprot
proteins
sequence_length
861
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q14764}. Nucleus, nuclear pore complex {ECO:0000250|UniProtKB:Q14764}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q14764}.
uniprot
proteins