Ass1
entrez
25698
canonical
uniprot
P09034
canonical
ensembl
ENSRNOG00000008837
resolver
ensembl
ENSRNOG00055007404
resolver
ensembl
ENSRNOG00060032679
resolver
ensembl
ENSRNOG00065022632
resolver
ensp
ENSRNOP00000076301
resolver
ensp
ENSRNOP00055009799
resolver
ensp
ENSRNOP00060046825
resolver
ensp
ENSRNOP00065031369
resolver
enst
ENSRNOT00000093365
resolver
enst
ENSRNOT00055012348
resolver
enst
ENSRNOT00060056659
resolver
enst
ENSRNOT00065038665
resolver
genesymbol
Ass1
resolver
genesymbol_syn
Ass
resolver
uniprot_entry
ASSY_RAT
resolver
amino_acid_sequence
MSSKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVFIEDVSKEFVEEFIWPAVQSSALYEDRYLLGTSLARPCIARKQVEIAQREGAKYVSHGATGKGNDQVRFELTCYSLAPQIKVIAPWRMPEFYNRFKGRNDLMEYAKQHGIPIPVTPKSPWSMDENLMHISYEAGILENPKNQAPPGLYTKTQDPAKAPNTPDVLEIEFKKGVPVKVTNVKDGTTHSTSLDLFMYLNEVAGKHGVGRIDIVENRFIGMKSRGIYETPAGTILYHAHLDIEAFTMDREVRKIKQGLGLKFAELVYTGFWHSPECEFVRHCIDKSQERVEGKVQVSVFKGQVYILGRESPLSLYNEELVSMNVQGDYEPIDATGFININSLRLKEYHRLQSKVTAK
uniprot
proteins
ec_number
6.3.4.5
uniprot
proteins
function
FUNCTION: One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals (Probable). Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues (Probable). Indirectly, may be involved in the control of blood pressure (PubMed:19491403). {ECO:0000269|PubMed:19491403, ECO:0000305|PubMed:19491403}.
uniprot
proteins
mass_dalton
46496
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. {ECO:0000305|PubMed:19491403}.; PATHWAY: Nitrogen metabolism; urea cycle; (N(omega)-L-arginino)succinate from L-aspartate and L-citrulline: step 1/1. {ECO:0000305|PubMed:19491403}.
uniprot
proteins
post_translational_modification
PTM: Acetylated by CLOCK in a circadian manner which negatively regulates its enzyme activity. Deacetylated by histone deacetylases. {ECO:0000250|UniProtKB:P00966}.
uniprot
proteins
protein_family
Argininosuccinate synthase family
uniprot
proteins
protein_family
Type 1 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19491403
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
3174461
uniprot
proteins
sequence_length
412
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305|PubMed:19491403}.
uniprot
proteins