Hsd11b2
entrez
25117
canonical
uniprot
P50233
canonical
ensembl
ENSRNOG00000017084
resolver
ensembl
ENSRNOG00055018967
resolver
ensembl
ENSRNOG00060012933
resolver
ensp
ENSRNOP00000023130
resolver
ensp
ENSRNOP00055026178
resolver
ensp
ENSRNOP00060017414
resolver
enst
ENSRNOT00000023130
resolver
enst
ENSRNOT00055032356
resolver
enst
ENSRNOT00060021998
resolver
genesymbol
Hsd11b2
resolver
genesymbol_syn
Hsd11k
resolver
uniprot_entry
DHI2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by glycyrrhetinic acid (By similarity). Induced by progesterone, through the Ihh signaling pathway (By similarity). {ECO:0000250|UniProtKB:P51661, ECO:0000250|UniProtKB:P80365}.
uniprot
proteins
amino_acid_sequence
MERWPWPSGGAWLLVAARALLQLLRSDLRLGRPLLAALALLAALDWLCQRLLPPPAALVVLAGAGWIALSRLARPPRLPVATRAVLITGCDTGFGKETAKKLDAMGFTVLATVLDLNGPGALELRARCSPRLKLLQMDLTKPEDISRVLEITKAHTASTGLWGLVNNAGLNMVVADVELSPVVTFRECMEVNFFGALELTKGLLPLLRHSRGRIVTVGSPAGDMPYPCLAAYGTSKAAIALLMDTFSCELLPWGIKVSIIQPGCFKTEAVTNVNLWEKRKQLLLANLPRELLQAYGEDYIEHLHGQFLNSLRMALPDLSPVVDAIIDALLAAQPRSRYYTGRGLGLMYFIHHYLPGGLRRRFLQNFFISHLLPRALRPGQPGPVHDTTQDPNPSPTVSAL
uniprot
proteins
ec_number
1.1.1.-
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of biologically active 11beta-hydroxyglucocorticoids (11beta-hydroxysteroid) such as corticosterone, to inactive 11-ketoglucocorticoids (11-oxosteroid) such as 11-dehydrocorticosterone, in the presence of NAD(+) (PubMed:7649078). Functions as a dehydrogenase (oxidase), thereby decreasing the concentration of active glucocorticoids, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids (PubMed:34028587, PubMed:7649078). Plays an important role in maintaining glucocorticoids balance during preimplantation and protects the fetus from excessive maternal corticosterone exposure (PubMed:34028587). Catalyzes the oxidation of 11beta-hydroxytestosterone (11beta,17beta-dihydroxyandrost-4-ene-3-one) to 11-ketotestosterone (17beta-hydroxyandrost-4-ene-3,11-dione), a major bioactive androgen (By similarity). Catalyzes the conversion of 11beta-hydroxyandrostenedione (11beta-hydroxyandrost-4-ene-3,17-dione) to 11-ketoandrostenedione (androst-4-ene-3,11,17-trione), which can be further metabolized to 11-ketotestosterone (By similarity). Converts 7-beta-25-dihydroxycholesterol to 7-oxo-25-hydroxycholesterol in vitro (By similarity). 7-beta-25-dihydroxycholesterol (not 7-oxo-25-hydroxycholesterol) acts as a ligand for the G protein-coupled receptor (GPCR) Epstein-Barr virus-induced gene 2 (EBI2) and may thereby regulate immune cell migration (By similarity). Catalyzes the conversion of 7-beta-hydroxycholesterol into 7-ketocholesterol (7-oxocholesterol), a precursor of 7-keto,27-hydroxycholesterol, which activates smoothened (SMO) and the smoothened signaling pathway (By similarity). {ECO:0000250|UniProtKB:P51661, ECO:0000250|UniProtKB:P80365, ECO:0000269|PubMed:7649078, ECO:0000303|PubMed:34028587, ECO:0000303|PubMed:7649078}.
uniprot
proteins
mass_dalton
43726
uniprot
proteins
pathway_participation
PATHWAY: Steroid metabolism. {ECO:0000305}.
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
1312193
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
34028587
uniprot
proteins
pubmed
7649078
uniprot
proteins
sequence_length
400
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome {ECO:0000250|UniProtKB:P80365}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P80365}.
uniprot
proteins