Thoc7
entrez
66231
canonical
uniprot
Q7TMY4
canonical
ensembl
ENSMUSG00000053453
resolver
ensp
ENSMUSP00000065819
resolver
ensp
ENSMUSP00000153123
resolver
ensp
ENSMUSP00000153560
resolver
ensp
ENSMUSP00000169375
resolver
ensp
ENSMUSP00000169378
resolver
ensp
ENSMUSP00000335970
resolver
ensp
ENSMUSP00000335971
resolver
ensp
ENSMUSP00000335973
resolver
enst
ENSMUST00000225325
resolver
genesymbol
Thoc7
resolver
genesymbol_syn
Nif3l1bp1
resolver
uniprot
A0A286YCS0
resolver
uniprot
Q3UIA6
resolver
uniprot
Q80VT4
resolver
uniprot
Q9CQ50
resolver
uniprot_entry
A0A286YCS0_MOUSE
resolver
uniprot_entry
THOC7_MOUSE
resolver
uniprot_sec
Q3UIA6
resolver
uniprot_sec
Q80VT4
resolver
uniprot_sec
Q9CQ50
resolver
amino_acid_sequence
MGAVTDDEVIRKRLLIDGDGAGDDRRINLLVKSFIKWCNSGSQEEGYSQYQRMLSTLSQCEFSMGKTLLVYDMNLREMENYEKIYKEIECSIAGAHEKIAECKKQILQAKRIRKNRQEYDALAKVIQHHPDRHETLKELEALGKELEHLSHIKESVEDKLELRRKQFHVLLSTIHELQQTLENDDKLSEVDEAQESTMEADPKP
uniprot
proteins
function
FUNCTION: Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. Required for efficient export of polyadenylated RNA. Plays a key structural role in the oligomerization of the THO-DDX39B complex. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. {ECO:0000250|UniProtKB:Q6I9Y2}.
uniprot
proteins
mass_dalton
23715
uniprot
proteins
protein_family
THOC7 family
uniprot
proteins
pubmed
12951069
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16465402
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
204
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6I9Y2}. Nucleus {ECO:0000250|UniProtKB:Q6I9Y2}. Nucleus speckle {ECO:0000250|UniProtKB:Q6I9Y2}. Note=Interaction with THOC5 is required for nuclear localization. {ECO:0000250|UniProtKB:Q6I9Y2}.
uniprot
proteins