Slc4a1
entrez
20533
canonical
uniprot
P04919
canonical
ensembl
ENSMUSG00000006574
resolver
ensp
ENSMUSP00000006749
resolver
genesymbol
Slc4a1
resolver
genesymbol_syn
Ae1
resolver
uniprot
Q3TZ29
resolver
uniprot
Q53ZN9
resolver
uniprot_entry
B3AT_MOUSE
resolver
uniprot_entry
Q3TZ29_MOUSE
resolver
uniprot_entry
Q53ZN9_MOUSE
resolver
amino_acid_sequence
MGDMRDHEEVLEIPDRDSEEELENIIGQIAYRDLTIPVTEMQDPEALPTEQTATDYVPSSTSTPHPSSGQVYVELQELMMDQRNQELQWVEAAHWIGLEENLREDGVWGRPHLSYLTFWSLLELQKVFSKGTFLLGLAETSLAGVANHLLDCFIYEDQIRPQDREELLRALLLKRSHAEDLGNLEGVKPAVLTRSGGASEPLLPHQPSLETQLYCGQAEGGSEGPSTSGTLKIPPDSETTLVLVGRANFLEKPVLGFVRLKEAVPLEDLVLPEPVGFLLVLLGPEAPHVDYTQLGRAAATLMTERVFRITASMAHNREELLRSLESFLDCSLVLPPTDAPSEKALLNLVPVQKELLRRRYLPSPAKPDPNLYNTLDLNGGKGGPGDEDDPLRRTGRIFGGLIRDIRRRYPYYLSDITDALSPQVLAAVIFIYFAALSPAVTFGGLLGEKTRNLMGVSELLISTAVQGILFALLGAQPLLVLGFSGPLLVFEEAFFSFCESNNLEYIVGRAWIGFWLILLVMLVVAFEGSFLVQYISRYTQEIFSFLISLIFIYETFSKLIKIFQDYPLQQTYAPVVMKPKPQGPVPNTALFSLVLMAGTFLLAMTLRKFKNSTYFPGKLRRVIGDFGVPISILIMVLVDSFIKGTYTQKLSVPDGLKVSNSSARGWVIHPLGLYRLFPTWMMFASVLPALLVFILIFLESQITTLIVSKPERKMIKGSGFHLDLLLVVGMGGVAALFGMPWLSATTVRSVTHANALTVMGKASGPGAAAQIQEVKEQRISGLLVSVLVGLSILMEPILSRIPLAVLFGIFLYMGVTSLSGIQLFDRILLLFKPPKYHPDVPFVKRVKTWRMHLFTGIQIICLAVLWVVKSTPASLALPFVLILTVPLRRLILPLIFRELELQCLDGDDAKVTFDEENGLDEYDEVPMPV
uniprot
proteins
function
FUNCTION: Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Component of the ankyrin-1 complex of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine. {ECO:0000250|UniProtKB:P02730}.
uniprot
proteins
mass_dalton
103136
uniprot
proteins
protein_family
Anion exchanger (TC 2.A.31) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2410791
uniprot
proteins
pubmed
2713407
uniprot
proteins
pubmed
3015590
uniprot
proteins
pubmed
3036795
uniprot
proteins
pubmed
3840489
uniprot
proteins
pubmed
9490702
uniprot
proteins
sequence_length
929
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:2713407}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P02730}. Basolateral cell membrane {ECO:0000250|UniProtKB:P02730}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P02730}. Note=Detected in the erythrocyte cell membrane and on the basolateral membrane of alpha-intercalated cells in the collecting duct in the kidney. {ECO:0000250|UniProtKB:P02730}.
uniprot
proteins
transmembrane_region
TRANSMEM 423..446; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P02730"; TRANSMEM 455..475; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P02730"; TRANSMEM 479..495; /note="Discontinuously helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P02730"; TRANSMEM 505..525; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P02730"; TRANSMEM 538..560; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P02730"; TRANSMEM 589..609; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P02730"; TRANSMEM 621..641; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P02730"; TRANSMEM 682..702; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P02730"; TRANSMEM 719..737; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:P02730"; TRANSMEM 738..755; /note="Discontinuously helical; Name=10"; /evidence="ECO:0000250|UniProtKB:P02730"; TRANSMEM 779..799; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:P02730"; TRANSMEM 800..818; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:P02730
uniprot
proteins