CEP97
entrez
79598
canonical
uniprot
Q8IW35
canonical
ensembl
ENSG00000182504
resolver
ensp
ENSP00000342510
resolver
ensp
ENSP00000418185
resolver
ensp
ENSP00000515874
resolver
ensp
ENSP00000515875
resolver
ensp
ENSP00000515897
resolver
enst
ENST00000494050
resolver
enst
ENST00000704366
resolver
enst
ENST00000704367
resolver
enst
ENST00000704445
resolver
genesymbol
CEP97
resolver
genesymbol_syn
LRRIQ2
resolver
hgnc
HGNC:26244
resolver
uniprot
A0A994J4L0
resolver
uniprot
A0A994J522
resolver
uniprot
A0A994J7E5
resolver
uniprot
B4DGU8
resolver
uniprot
B5MDY8
resolver
uniprot
E9PG22
resolver
uniprot
Q8NA71
resolver
uniprot
Q9H5T9
resolver
uniprot_entry
A0A994J4L0_HUMAN
resolver
uniprot_entry
A0A994J522_HUMAN
resolver
uniprot_entry
A0A994J7E5_HUMAN
resolver
uniprot_entry
B4DGU8_HUMAN
resolver
uniprot_entry
CEP97_HUMAN
resolver
uniprot_entry
E9PG22_HUMAN
resolver
uniprot_sec
B5MDY8
resolver
uniprot_sec
Q8NA71
resolver
uniprot_sec
Q9H5T9
resolver
amino_acid_sequence
MAVARVDAALPPGEGSVVNWSGQGLQKLGPNLPCEADIHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQIGDLSKLVSLKTLLLHGNIITSLRMAPAYLPRSLAILSLAENEIRDLNEISFLASLTELEQLSIMNNPCVMATPSIPGFDYRPYIVSWCLNLRVLDGYVISQKESLKAEWLYSQGKGRAYRPGQHIQLVQYLATVCPLTSTLGLQTAEDAKLEKILSKQRFHQRQLMNQSQNEELSPLVPVETRASLIPEHSSPVQDCQISQESEPVIQVNSWVGINSNDDQLFAVKNNFPASVHTTRYSRNDLHLEDIQTDEDKLNCSLLSSESTFMPVASGLSPLSPTVELRLQGINLGLEDDGVADESVKGLESQVLDKEEEQPLWAANENSVQMMRSEINTEVNEKAGLLPCPEPTIISAILKDDNHSLTFFPESTEQKQSDIKKPENTQPENKETISQATSEKLPMILTQRSVALGQDKVALQKLNDAATKLQACWRGFYARNYNPQAKDVRYEIRLRRMQEHIVCLTDEIRRLRKERDEERIKKFVQEEAFRFLWNQVRSLQVWQQTVDQRLSSWHTDVPPISSTLVPSKHPLFTQSQESSCDQNADWFIASDVAPQEKSLPEFPDSGFHSSLTEQVHSLQHSLDFEKSSTEGSESSIMGNSIDTVRYGKESDLGDVSEEHGEWNKESSNNEQDNSLLEQYLTSVQQLEDADERTNFDTETRDSKLHIACFPVQLDTLSDGASVDESHGISPPLQGEISQTQENSKLNAEVQGQQPECDSTFQLLHVGVTV
uniprot
proteins
function
FUNCTION: Acts as a key negative regulator of ciliogenesis in collaboration with CCP110 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545, PubMed:30375385, PubMed:30404837). Required for recruitment of CCP110 to the centrosome (PubMed:17719545). {ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:30375385, ECO:0000269|PubMed:30404837}.
uniprot
proteins
mass_dalton
96981
uniprot
proteins
mutagenesis
MUTAGEN 582; /note="K->R: Strongly reduced ubiquitination; when associated with R-617 and R-618."; /evidence="ECO:0000269|PubMed:30404837"; MUTAGEN 617; /note="K->R: Strongly reduced ubiquitination; when associated with R-582 and R-618."; /evidence="ECO:0000269|PubMed:30404837"; MUTAGEN 618; /note="K->R: Strongly reduced ubiquitination; when associated with R-582 and R-617."; /evidence="ECO:0000269|PubMed:30404837
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the BCR(BACURD3) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD10/BACURD3 and RBX1; leading to proteasomal degradation. {ECO:0000269|PubMed:30404837}.
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
17719545
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19460342
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21620453
uniprot
proteins
pubmed
22261722
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24421332
uniprot
proteins
pubmed
30375385
uniprot
proteins
pubmed
30404837
uniprot
proteins
sequence_length
865
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:30375385}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:30375385}. Note=Recruited at the distal end of the mother centriole by MPHOSPH9. {ECO:0000269|PubMed:30375385}.
uniprot
proteins