TACC1
entrez
6867
canonical
uniprot
O75410
canonical
ensembl
ENSG00000147526
resolver
ensp
ENSP00000276520
resolver
ensp
ENSP00000321703
resolver
ensp
ENSP00000428253
resolver
ensp
ENSP00000428450
resolver
ensp
ENSP00000428687
resolver
ensp
ENSP00000428706
resolver
ensp
ENSP00000430355
resolver
ensp
ENSP00000430959
resolver
ensp
ENSP00000555384
resolver
ensp
ENSP00000555392
resolver
ensp
ENSP00000555393
resolver
ensp
ENSP00000555394
resolver
ensp
ENSP00000555395
resolver
ensp
ENSP00000660437
resolver
ensp
ENSP00000660438
resolver
ensp
ENSP00000776282
resolver
enst
ENST00000519416
resolver
enst
ENST00000520973
resolver
enst
ENST00000522904
resolver
genesymbol
TACC1
resolver
genesymbol_syn
KIAA1103
resolver
hgnc
HGNC:11522
resolver
uniprot
B2RBD9
resolver
uniprot
B4E302
resolver
uniprot
B7Z3G3
resolver
uniprot
D3DSX6
resolver
uniprot
E5RFM9
resolver
uniprot
E7ET87
resolver
uniprot
E7EVI4
resolver
uniprot
Q6Y687
resolver
uniprot
Q86YG7
resolver
uniprot
Q8IUJ2
resolver
uniprot
Q8IUJ3
resolver
uniprot
Q8IUJ4
resolver
uniprot
Q8IZG2
resolver
uniprot
Q8NEY7
resolver
uniprot
Q9UPP9
resolver
uniprot_entry
B7Z3G3_HUMAN
resolver
uniprot_entry
E5RFM9_HUMAN
resolver
uniprot_entry
E7ET87_HUMAN
resolver
uniprot_entry
E7EVI4_HUMAN
resolver
uniprot_entry
TACC1_HUMAN
resolver
uniprot_sec
B2RBD9
resolver
uniprot_sec
B4E302
resolver
uniprot_sec
D3DSX6
resolver
uniprot_sec
Q6Y687
resolver
uniprot_sec
Q86YG7
resolver
uniprot_sec
Q8IUJ2
resolver
uniprot_sec
Q8IUJ3
resolver
uniprot_sec
Q8IUJ4
resolver
uniprot_sec
Q8IZG2
resolver
uniprot_sec
Q8NEY7
resolver
uniprot_sec
Q9UPP9
resolver
amino_acid_sequence
MAFSPWQILSPVQWAKWTWSAVRGGAAGEDEAGGPEGDPEEEDSQAETKSLSFSSDSEGNFETPEAETPIRSPFKESCDPSLGLAGPGAKSQESQEADEQLVAEVVEKCSSKTCSKPSENEVPQQAIDSHSVKNFREEPEHDFSKISIVRPFSIETKDSTDISAVLGTKAAHGCVTAVSGKALPSSPPDALQDEAMTEGSMGVTLEASAEADLKAGNSCPELVPSRRSKLRKPKPVPLRKKAIGGEFSDTNAAVEGTPLPKASYHFSPEELDENTSPLLGDARFQKSPPDLKETPGTLSSDTNDSGVELGEESRSSPLKLEFDFTEDTGNIEARKALPRKLGRKLGSTLTPKIQKDGISKSAGLEQPTDPVARDGPLSQTSSKPDPSQWESPSFNPFGSHSVLQNSPPLSSEGSYHFDPDNFDESMDPFKPTTTLTSSDFCSPTGNHVNEILESPKKAKSRLITSGCKVKKHETQSLALDACSRDEGAVISQISDISNRDGHATDEEKLASTSCGQKSAGAEVKGEPEEDLEYFECSNVPVSTINHAFSSSEAGIEKETCQKMEEDGSTVLGLLESSAEKAPVSVSCGGESPLDGICLSESDKTAVLTLIREEIITKEIEANEWKKKYEETRQEVLEMRKIVAEYEKTIAQMIEDEQRTSMTSQKSFQQLTMEKEQALADLNSVERSLSDLFRRYENLKGVLEGFKKNEEALKKCAQDYLARVKQEEQRYQALKIHAEEKLDKANEEIAQVRTKAKAESAALHAGLRKEQMKVESLERALQQKNQEIEELTKICDELIAKLGKTD
uniprot
proteins
function
FUNCTION: Involved in transcription regulation induced by nuclear receptors, including in T3 thyroid hormone and all-trans retinoic acid pathways (PubMed:20078863). Might promote the nuclear localization of the receptors (PubMed:20078863). Likely involved in the processes that promote cell division prior to the formation of differentiated tissues. {ECO:0000269|PubMed:20078863}.
uniprot
proteins
mass_dalton
87794
uniprot
proteins
mutagenesis
MUTAGEN 228; /note="S->A: Impairs phosphorylation by AURKC."; /evidence="ECO:0000269|PubMed:21531210"; MUTAGEN 609..610; /note="LI->AA: Decreases interaction with THRA."; /evidence="ECO:0000269|PubMed:20078863
uniprot
proteins
post_translational_modification
PTM: Isoform 1 is heavily phosphorylated; isoform 6 is not. {ECO:0000269|PubMed:12165861, ECO:0000269|PubMed:21531210}.
uniprot
proteins
protein_family
TACC family
uniprot
proteins
pubmed
10435627
uniprot
proteins
pubmed
10470851
uniprot
proteins
pubmed
11121038
uniprot
proteins
pubmed
11903063
uniprot
proteins
pubmed
12087473
uniprot
proteins
pubmed
12165861
uniprot
proteins
pubmed
12547166
uniprot
proteins
pubmed
14603251
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14767476
uniprot
proteins
pubmed
15064709
uniprot
proteins
pubmed
15207008
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20078863
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21531210
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25807930
uniprot
proteins
sequence_length
805
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14767476}. Nucleus {ECO:0000269|PubMed:14767476}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21531210}. Midbody {ECO:0000269|PubMed:21531210}. Note=Nucleus during interphase. Weakly concentrated at centrosomes during mitosis and colocalizes with AURKC at the midbody during cytokinesis. {ECO:0000269|PubMed:21531210}.; SUBCELLULAR LOCATION: [Isoform 5]: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 10]: Cytoplasm {ECO:0000269|PubMed:20078863}.
uniprot
proteins