GAB1
entrez
2549
canonical
uniprot
Q13480
canonical
ensembl
ENSG00000109458
resolver
ensp
ENSP00000262994
resolver
ensp
ENSP00000262995
resolver
ensp
ENSP00000424554
resolver
enst
ENST00000505913
resolver
genesymbol
GAB1
resolver
hgnc
HGNC:4066
resolver
uniprot
A8K152
resolver
uniprot
B7Z3B9
resolver
uniprot
F6U634
resolver
uniprot
Q4W5G2
resolver
uniprot
Q6P1W2
resolver
uniprot
Q9HA84
resolver
uniprot_entry
B7Z3B9_HUMAN
resolver
uniprot_entry
F6U634_HUMAN
resolver
uniprot_entry
GAB1_HUMAN
resolver
uniprot_entry
Q9HA84_HUMAN
resolver
uniprot_sec
A8K152
resolver
uniprot_sec
Q4W5G2
resolver
uniprot_sec
Q6P1W2
resolver
amino_acid_sequence
MSGGEVVCSGWLRKSPPEKKLKRYAWKRRWFVLRSGRLTGDPDVLEYYKNDHAKKPIRIIDLNLCQQVDAGLTFNKKEFENSYIFDINTIDRIFYLVADSEEEMNKWVRCICDICGFNPTEEDPVKPPGSSLQAPADLPLAINTAPPSTQADSSSATLPPPYQLINVPPHLETLGIQEDPQDYLLLINCQSKKPEPTRTHADSAKSTSSETDCNDNVPSHKNPASSQSKHGMNGFFQQQMIYDSPPSRAPSASVDSSLYNLPRSYSHDVLPKVSPSSTEADGELYVFNTPSGTSSVETQMRHVSISYDIPPTPGNTYQIPRTFPEGTLGQTSKLDTIPDIPPPRPPKPHPAHDRSPVETCSIPRTASDTDSSYCIPTAGMSPSRSNTISTVDLNKLRKDASSQDCYDIPRAFPSDRSSSLEGFHNHFKVKNVLTVGSVSSEELDENYVPMNPNSPPRQHSSSFTEPIQEANYVPMTPGTFDFSSFGMQVPPPAHMGFRSSPKTPPRRPVPVADCEPPPVDRNLKPDRKVKPAPLEIKPLPEWEELQAPVRSPITRSFARDSSRFPMSPRPDSVHSTTSSSDSHDSEENYVPMNPNLSSEDPNLFGSNSLDGGSSPMIKPKGDKQVEYLDLDLDSGKSTPPRKQKSSGSGSSVADERVDYVVVDQQKTLALKSTREAWTDGRQSTESETPAKSVK
uniprot
proteins
disease_involvement
DISEASE: Deafness, autosomal recessive, 26 (DFNB26) [MIM:605428]: A form of non-syndromic sensorineural deafness characterized by prelingual, severe to profound hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269|PubMed:29408807}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Involved in the MET/HGF-signaling pathway (PubMed:29408807). {ECO:0000269|PubMed:29408807}.
uniprot
proteins
mass_dalton
76616
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in response to FGFR1 activation. Phosphorylated on tyrosine residue(s) by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Tyrosine phosphorylation of GAB1 mediates interaction with several proteins that contain SH2 domains. Phosphorylated on tyrosine residues by HCK upon IL6 signaling. {ECO:0000269|PubMed:15010462}.
uniprot
proteins
protein_family
GAB family
uniprot
proteins
pubmed
12475979
uniprot
proteins
pubmed
12486104
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15010462
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
15863030
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
29408807
uniprot
proteins
pubmed
8596638
uniprot
proteins
sequence_length
694
uniprot
proteins