Rab43
entrez
500249
canonical
uniprot
Q53B90
canonical
ensembl
ENSRNOG00000037768
resolver
ensembl
ENSRNOG00055012969
resolver
ensembl
ENSRNOG00060024176
resolver
ensembl
ENSRNOG00065015079
resolver
ensp
ENSRNOP00000013299
resolver
ensp
ENSRNOP00055018048
resolver
ensp
ENSRNOP00060034762
resolver
ensp
ENSRNOP00065019531
resolver
enst
ENSRNOT00000013299
resolver
enst
ENSRNOT00055022211
resolver
enst
ENSRNOT00060041918
resolver
enst
ENSRNOT00065024961
resolver
genesymbol
Rab43
resolver
uniprot_entry
RAB43_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) including USP6NL, which increase the GTP hydrolysis activity (By similarity). Inhibited by GDP dissociation inhibitors (GDIs) (By similarity). {ECO:0000250|UniProtKB:P62820, ECO:0000250|UniProtKB:Q86YS6}.
uniprot
proteins
amino_acid_sequence
MAGPGPGDQDEHYDFLFKLVLVGDASVGKTCVVQRFKTGAFSARQGSTIGVDFTMKTLEIQGKRVKLQIWDTAGQERFRTITQSYYRSANGAILAYDISKRSTFLSVPHWIEDVRKYAGSNIVQLLIGNKSDLADLREVPLAEAQSLAEHYDILCAIETSAKDSSNVEEAFTRVATELIMRHGGPMFSEKNTDHIQLDSKDIAESWGCGC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Involved in retrograde transport from the endocytic pathway to the Golgi apparatus. Required for the structural integrity of the Golgi complex. Also controls the anterograde ER-to-Golgi transport of nascent G protein-coupled receptors (including ADRA2A, ADRA2B, ADRA2C, ADRA1B, ADRB2 and AGTR1) and regulates the ER sorting of GPCR members by virtue of its ability to interact directly. Involved in the transport of Shiga toxin from early and recycling endosomes to the trans-Golgi network. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. {ECO:0000250|UniProtKB:Q86YS6}.
uniprot
proteins
mass_dalton
23229
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
sequence_length
210
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q86YS6}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus {ECO:0000250|UniProtKB:Q86YS6}. Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q86YS6}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. {ECO:0000250|UniProtKB:Q86YS6}.
uniprot
proteins