Cdkn2a
entrez
25163
canonical
uniprot
Q9R0Z3
canonical
ensembl
ENSRNOG00000059837
resolver
ensembl
ENSRNOG00065019345
resolver
ensp
ENSRNOP00000087870
resolver
enst
ENSRNOT00000103638
resolver
genesymbol
Cdkn2a
resolver
genesymbol_syn
P16ink4a
resolver
uniprot_entry
CDN2A_RAT
resolver
amino_acid_sequence
MESSADRLARAAALGREHEVRALLEAGASPNAPNTFGRTPIQVMMMGNVKVAALLLSYGADSNCEDPTTLSRPVHDAAREGFLDTLVVLHQAGARLDVRDAWGRLPLDLALERGHHDVVRYLRYLLSSAGNVSRVTDRHNFCSSTPRCLGLRGQPPKQR
uniprot
proteins
function
FUNCTION: Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein (By similarity). {ECO:0000250|UniProtKB:P51480}.
uniprot
proteins
mass_dalton
17366
uniprot
proteins
post_translational_modification
PTM: Phosphorylation seems to increase interaction with CDK4. {ECO:0000250}.
uniprot
proteins
protein_family
CDKN2 cyclin-dependent kinase inhibitor family
uniprot
proteins
pubmed
9032263
uniprot
proteins
sequence_length
159
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
uniprot
proteins