Aif1
entrez
11629
canonical
uniprot
O70200
canonical
ensembl
ENSMUSG00000024397
resolver
ensp
ENSMUSP00000025257
resolver
ensp
ENSMUSP00000133709
resolver
ensp
ENSMUSP00000134214
resolver
ensp
ENSMUSP00000355831
resolver
ensp
ENSMUSP00000355832
resolver
enst
ENSMUST00000025257
resolver
enst
ENSMUST00000172693
resolver
enst
ENSMUST00000173324
resolver
genesymbol
Aif1
resolver
genesymbol_syn
Iba1
resolver
uniprot
Q4FJL9
resolver
uniprot_entry
AIF1_MOUSE
resolver
uniprot_entry
Q4FJL9_MOUSE
resolver
amino_acid_sequence
MSQSRDLQGGKAFGLLKAQQEERLEGINKQFLDDPKYSNDEDLPSKLEAFKVKYMEFDLNGNGDIDIMSLKRMLEKLGVPKTHLELKRLIREVSSGSEETFSYSDFLRMMLGKRSAILRMILMYEEKNKEHKRPTGPPAKKAISELP
uniprot
proteins
function
FUNCTION: Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. {ECO:0000269|PubMed:10934045, ECO:0000269|PubMed:11500035, ECO:0000269|PubMed:11722645, ECO:0000269|PubMed:11916959, ECO:0000269|PubMed:14756805}.
uniprot
proteins
mass_dalton
16911
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine residues. {ECO:0000250}.
uniprot
proteins
pubmed
10934045
uniprot
proteins
pubmed
11500035
uniprot
proteins
pubmed
11722645
uniprot
proteins
pubmed
11916959
uniprot
proteins
pubmed
14656967
uniprot
proteins
pubmed
14756805
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17011575
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
147
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10934045}. Cell projection, ruffle membrane {ECO:0000269|PubMed:10934045, ECO:0000269|PubMed:14756805}; Peripheral membrane protein; Cytoplasmic side. Cell projection, phagocytic cup {ECO:0000269|PubMed:10934045, ECO:0000269|PubMed:14756805}. Note=Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis. {ECO:0000269|PubMed:10934045}.
uniprot
proteins