HTR1A
entrez
3350
canonical
uniprot
P08908
canonical
ensembl
ENSG00000178394
resolver
ensp
ENSP00000316244
resolver
enst
ENST00000323865
resolver
genesymbol
HTR1A
resolver
genesymbol_syn
ADRB2RL1
resolver
genesymbol_syn
ADRBRL1
resolver
hgnc
HGNC:5286
resolver
uniprot
A8K5W4
resolver
uniprot
Q5ZGX3
resolver
uniprot
Q6LAE7
resolver
uniprot_entry
5HT1A_HUMAN
resolver
uniprot_entry
A8K5W4_HUMAN
resolver
uniprot_entry
Q5ZGX3_HUMAN
resolver
uniprot_sec
Q6LAE7
resolver
activity_regulation
ACTIVITY REGULATION: G protein-coupled receptor activity is regulated by lipids: phosphatidylinositol 4-phosphate increases HTR1A-mediated activity (PubMed:33762731). Binding to aripiprazol drug is regulated by cholesterol, which shapes the ligand-binding pocket, determining the specificity for aripiprazol (PubMed:33762731). Activated by IHCH-7179 small molecule: IHCH-7179 acts both as an agonist activator for HTR1A and as an antagonist inhibitor for HTR2A (PubMed:38552625). Activated by SEP-363856 small molecule: IHCH-7179 acts both as an agonist activator for HTR1A and TAAR1 (PubMed:37935376, PubMed:37935377). {ECO:0000269|PubMed:33762731, ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:38552625}.
uniprot
proteins
amino_acid_sequence
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
uniprot
proteins
disease_involvement
DISEASE: Periodic fever, menstrual cycle-dependent (PFMC) [MIM:614674]: A condition characterized by recurrent fevers up to 40 degrees Celsius associated with the luteal phase of the menstrual cycle. Women show menstrual cycle-dependent physiologic changes in relation to sex hormone levels. Because ovulation triggers a significant change in the hormonal milieu that is similar to local inflammation, a 0.5 to 1.0 degree Celsius increase in basal body temperature after ovulation is commonly associated with progesterone secretion and is believed to be triggered by the induction of several inflammatory cytokines. {ECO:0000269|PubMed:21990073}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:22957663, PubMed:3138543, PubMed:33762731, PubMed:37935376, PubMed:37935377, PubMed:8138923, PubMed:8393041). Also functions as a receptor for various drugs and psychoactive substances (PubMed:22957663, PubMed:3138543, PubMed:33762731, PubMed:38552625, PubMed:8138923, PubMed:8393041). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:22957663, PubMed:3138543, PubMed:33762731, PubMed:8138923, PubMed:8393041). HTR1A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (PubMed:33762731, PubMed:35610220). Beta-arrestin family members regulate signaling by mediating both receptor desensitization and resensitization processes (PubMed:18476671, PubMed:20363322, PubMed:20945968). Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism (PubMed:18476671, PubMed:20363322, PubMed:20945968). Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior (PubMed:18476671, PubMed:20363322, PubMed:20945968). Plays a role in the response to anxiogenic stimuli (PubMed:18476671, PubMed:20363322, PubMed:20945968). {ECO:0000269|PubMed:22957663, ECO:0000269|PubMed:3138543, ECO:0000269|PubMed:33762731, ECO:0000269|PubMed:35610220, ECO:0000269|PubMed:37935376, ECO:0000269|PubMed:37935377, ECO:0000269|PubMed:38552625, ECO:0000269|PubMed:8138923, ECO:0000269|PubMed:8393041, ECO:0000303|PubMed:18476671, ECO:0000303|PubMed:20363322, ECO:0000303|PubMed:20945968}.
uniprot
proteins
mass_dalton
46107
uniprot
proteins
mutagenesis
MUTAGEN 134; /note="R->A: Reduced activation of G proteins."; /evidence="ECO:0000269|PubMed:33762731"; MUTAGEN 191; /note="K->A: Increased activation of G alpha proteins in response to SEP363856-binding."; /evidence="ECO:0000269|PubMed:37935376"; MUTAGEN 345; /note="K->A: Reduced activation of G proteins."; /evidence="ECO:0000269|PubMed:33762731"; MUTAGEN 365; /note="A->E,S: Reduced G(i)/(o)-coupled receptor activity."; /evidence="ECO:0000269|PubMed:35610220"; MUTAGEN 405; /note="K->A: Reduced activation of G proteins."; /evidence="ECO:0000269|PubMed:33762731
uniprot
proteins
protein_family
5-hydroxytryptamine receptor subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
HTR1A sub-subfamily
uniprot
proteins
pubmed
15014171
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1766875
uniprot
proteins
pubmed
18476671
uniprot
proteins
pubmed
20363322
uniprot
proteins
pubmed
20945968
uniprot
proteins
pubmed
21990073
uniprot
proteins
pubmed
22957663
uniprot
proteins
pubmed
23300088
uniprot
proteins
pubmed
26365466
uniprot
proteins
pubmed
3041227
uniprot
proteins
pubmed
3138543
uniprot
proteins
pubmed
33762731
uniprot
proteins
pubmed
35610220
uniprot
proteins
pubmed
37935376
uniprot
proteins
pubmed
37935377
uniprot
proteins
pubmed
38552625
uniprot
proteins
pubmed
7755630
uniprot
proteins
pubmed
8138923
uniprot
proteins
pubmed
8393041
uniprot
proteins
pubmed
9754630
uniprot
proteins
sequence_length
422
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22957663, ECO:0000269|PubMed:26365466, ECO:0000269|PubMed:3041227, ECO:0000269|PubMed:3138543, ECO:0000269|PubMed:8393041}; Multi-pass membrane protein {ECO:0000269|PubMed:22957663, ECO:0000269|PubMed:3041227, ECO:0000269|PubMed:3138543, ECO:0000269|PubMed:8393041}. Cell projection, dendrite {ECO:0000250|UniProtKB:P19327}.
uniprot
proteins
transmembrane_region
TRANSMEM 39..59; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:33762731, ECO:0007744|PDB:7E2X"; TRANSMEM 74..98; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:33762731, ECO:0007744|PDB:7E2X"; TRANSMEM 108..132; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:33762731, ECO:0007744|PDB:7E2X"; TRANSMEM 153..174; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:33762731, ECO:0007744|PDB:7E2X"; TRANSMEM 194..216; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:33762731, ECO:0007744|PDB:7E2X"; TRANSMEM 347..370; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:33762731, ECO:0007744|PDB:7E2X"; TRANSMEM 379..403; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:33762731, ECO:0007744|PDB:7E2X
uniprot
proteins