PRAP1
entrez
118471
canonical
uniprot
Q96NZ9
canonical
ensembl
ENSG00000165828
resolver
ensp
ENSP00000416126
resolver
ensp
ENSP00000486265
resolver
genesymbol
PRAP1
resolver
genesymbol_syn
UPA
resolver
hgnc
HGNC:23304
resolver
uniprot
A6XND8
resolver
uniprot
B7ZL57
resolver
uniprot
B7ZL58
resolver
uniprot
E9KL31
resolver
uniprot
Q5VWY4
resolver
uniprot
Q7Z4X5
resolver
uniprot
Q8IWR3
resolver
uniprot
Q8NCS2
resolver
uniprot_entry
A6XND8_HUMAN
resolver
uniprot_entry
PRAP1_HUMAN
resolver
uniprot_sec
B7ZL57
resolver
uniprot_sec
B7ZL58
resolver
uniprot_sec
E9KL31
resolver
uniprot_sec
Q5VWY4
resolver
uniprot_sec
Q7Z4X5
resolver
uniprot_sec
Q8IWR3
resolver
uniprot_sec
Q8NCS2
resolver
amino_acid_sequence
MRRLLLVTSLVVVLLWEAGAVPAPKVPIKMQVKHWPSEQDPEKAWGARVVEPPEKDDQLVVLFPVQKPKLLTTEEKPRGQGRGPILPGTKAWMETEDTLGHVLSPEPDHDSLYHPPPEEDQGEERPRLWVMPNHQVLLGPEEDQDHIYHPQ
uniprot
proteins
function
FUNCTION: Lipid-binding protein which promotes lipid absorption by facilitating MTTP-mediated lipid transfer (mainly triglycerides and phospholipids) and MTTP-mediated apoB lipoprotein assembly and secretion (By similarity). Protects the gastrointestinal epithelium from irradiation-induced apoptosis (By similarity). May play an important role in maintaining normal growth homeostasis in epithelial cells (PubMed:14583459). Involved in p53/TP53-dependent cell survival after DNA damage (PubMed:23235459). May down-regulate the expression of MAD1L1 and exert a suppressive role in mitotic spindle assembly checkpoint in hepatocellular carcinomas (PubMed:24374861). {ECO:0000250|UniProtKB:Q80XD8, ECO:0000269|PubMed:14583459, ECO:0000269|PubMed:23235459, ECO:0000269|PubMed:24374861}.
uniprot
proteins
mass_dalton
17208
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14583459
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20736409
uniprot
proteins
pubmed
23235459
uniprot
proteins
pubmed
24374861
uniprot
proteins
pubmed
32629119
uniprot
proteins
sequence_length
151
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:14583459}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q80XD8}.
uniprot
proteins