Thoc5
entrez
107829
canonical
uniprot
Q8BKT7
canonical
ensembl
ENSMUSG00000034274
resolver
ensp
ENSMUSP00000045580
resolver
ensp
ENSMUSP00000342575
resolver
enst
ENSMUST00000038237
resolver
genesymbol
Thoc5
resolver
genesymbol_syn
Fmip
resolver
genesymbol_syn
Kiaa0983
resolver
uniprot
A0A0R4J0J6
resolver
uniprot
Q69ZU0
resolver
uniprot
Q8CHR3
resolver
uniprot_entry
A0A0R4J0J6_MOUSE
resolver
uniprot_entry
THOC5_MOUSE
resolver
uniprot_sec
Q69ZU0
resolver
uniprot_sec
Q8CHR3
resolver
amino_acid_sequence
MSSESSKKRKPKVIRSDGTPTEGKRNRSDTEQEGKYYSEEAEVDLRDPGRDYELYKYTCQELQRLMAEIQDLKSKGSKDVAIEIEERRIQSCVHFMTLKKLNRLAHIRLKKGRDQTHEAKQKVDAYHLQLQNLLYEVMHLQKEITKCLEFKSKHEEIDLVSLEEFYSEAPPSISKAEITMGDPHQQTLARLDWELEQRKRLAEKYRECLSNKEKILKEIEVKRDYLSSLQPRLNSIMQASLPVQEYLFMPFDQAHKQYETARHLPPPLYVLFVQATAYGQACDKTLSVAIEGSVDEAKALFKPPEDSQDDESDSDAEEEQTTKRRRPTLGVQLDDKRKEMLKRHPLSVLLDLKCKDNSVLHLTFYYLMNLNIMTVKAKVTTAVELITPISAGDLLSPDSVLSCLYPGDHGKKTPNPANQYQFDKVGILTLRDYVLELGHPYLWVQKLGGLHFPKEQPQQTVMPDHSQSASHMETTMKLLKTRVQSRLALHKQFASLEHGIVPVTSDCQDLFPAKVVSRLVKWVIITHEDYMELHFTKDIVEAGLAGDTNLYYLALIERGTAKLQAAVVLNPGYSSIPPVFRLCLNWKGEKTNSNDDNIRAMESEVNVCYKELCGPRPSHQLLTNQLQRLCVLLDVYLETESHDDSFEGPKEFPQEKMCLRLFRGPSRMKPFKYNHPQGFFSHR
uniprot
proteins
function
FUNCTION: Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. Plays a key structural role in the oligomerization of the THO-DDX39B complex. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes; probably mediates association of the TREX and CFIm complexes. {ECO:0000250|UniProtKB:Q13769}.; FUNCTION: Regulates the expression of myeloid transcription factors CEBPA, CEBPB and GAB2 by enhancing the levels of phosphatidylinositol 3,4,5-trisphosphate. May be involved in the differentiation of granulocytes and adipocytes. Essential for hematopoietic primitive cell survival and plays an integral role in monocytic development.
uniprot
proteins
mass_dalton
78686
uniprot
proteins
mutagenesis
MUTAGEN 5..6; /note="SS->AA: Enhances nuclear localization."; /evidence="ECO:0000269|PubMed:15221008"; MUTAGEN 5..6; /note="SS->EE: Abolishes nuclear localization."; /evidence="ECO:0000269|PubMed:15221008"; MUTAGEN 8..9; /note="KR->TG: Abolishes nuclear localization."; /evidence="ECO:0000269|PubMed:15221008
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine upon binding to activated CSF1R; which causes a dissociation of the two proteins. Phosphorylation on Ser-5 and/or Ser-6 is required for nuclear export. Phosphorylated on Thr-328 in insulin-stimulated adipocytes. {ECO:0000269|PubMed:10597251, ECO:0000269|PubMed:15221008, ECO:0000269|PubMed:15451025, ECO:0000269|PubMed:19015024}.
uniprot
proteins
protein_family
THOC5 family
uniprot
proteins
pubmed
10597251
uniprot
proteins
pubmed
15221008
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15451025
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16909111
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19015024
uniprot
proteins
pubmed
20051105
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
683
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15221008}. Cytoplasm {ECO:0000269|PubMed:15221008}. Note=Shuttles between nucleus and cytoplasm. {ECO:0000250|UniProtKB:Q13769}.
uniprot
proteins