Hook2
entrez
170833
canonical
uniprot
Q7TMK6
canonical
ensembl
ENSMUSG00000052566
resolver
ensp
ENSMUSP00000067752
resolver
ensp
ENSMUSP00000148237
resolver
ensp
ENSMUSP00000248178
resolver
ensp
ENSMUSP00000248181
resolver
ensp
ENSMUSP00000248192
resolver
ensp
ENSMUSP00000248198
resolver
enst
ENSMUST00000064495
resolver
enst
ENSMUST00000209764
resolver
genesymbol
Hook2
resolver
uniprot
A0A1B0GT78
resolver
uniprot
Q3TKK8
resolver
uniprot
Q66JV2
resolver
uniprot
Q8BY47
resolver
uniprot
Q8R347
resolver
uniprot
Q8VCN4
resolver
uniprot
Q99LU2
resolver
uniprot_entry
A0A1B0GT78_MOUSE
resolver
uniprot_entry
HOOK2_MOUSE
resolver
uniprot_entry
Q3TKK8_MOUSE
resolver
uniprot_sec
Q66JV2
resolver
uniprot_sec
Q8BY47
resolver
uniprot_sec
Q8R347
resolver
uniprot_sec
Q8VCN4
resolver
uniprot_sec
Q99LU2
resolver
amino_acid_sequence
MSVDKAELCGSLLTWLQTFQVSPPCASPQDLSSGLAIAHVLNQIDPSWFNNEWLQGISEDSSPSWRLKVRKLEKILQSLVEYSKNVLGHPVSDQHLPDVSLIGEFSNPAELGKLLQLVLGCAISCEKKQEYIQRIMTLEESVQHVVMEAIQELMTKDTPDSLSPENYGNFDTQSRRYYFLSEEVEEGDHLQQHYLDLERQLLLLSEEKQNLAQENAALRERVGRSEVESAPGLTAKKLLLLQSQLEQLQEENFRLESSREDDRLRCLELEREVAELQQRNQALTSLSQEAQALKDEMDELRQSSERARQLEATLNSCRRRLGELQELRRQVRQLEERNAGHAERTRQLEEELRRAGSLRAQLEAQRRQVQELQGQWQEEAMKAEKWLFECRNLEEKCDLVTKEKERLLTERDSLREANEELRCAQLQPRGLAQADLSLDPTPSGLENLAAEILPAELRETLVRLQLENKRLCQQEAADRERQEELQRHLEEANRARHGLEAQQRLNQQQLSELRAQVEELQKALQEQGGKTEDPTLLKRKLEDHLQKLHEADLELQRKREYIEELEPPTDSSTARRIEELQDSLQKKDADLRAMEERYRRYVDKARTVIQTLEPKQRPPTVVSPEFHTLRSQLWERNLRIRQMEMDYEKSRRRQEQEEKLLISAWYSMGMALEHRAGEEHAPAHAQSFLAQQRLATNARRGPLGRQALSLRPTDKH
uniprot
proteins
function
FUNCTION: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Contributes to the establishment and maintenance of centrosome function. May function in the positioning or formation of aggresomes, which are pericentriolar accumulations of misfolded proteins, proteasomes and chaperones. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell. {ECO:0000250|UniProtKB:Q96ED9}.
uniprot
proteins
mass_dalton
83366
uniprot
proteins
protein_family
Hook family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17140400
uniprot
proteins
pubmed
25781171
uniprot
proteins
pubmed
28003339
uniprot
proteins
pubmed
28283191
uniprot
proteins
sequence_length
716
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17140400, ECO:0000269|PubMed:25781171}. Cytoplasm {ECO:0000269|PubMed:17140400}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17140400, ECO:0000269|PubMed:28003339}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q96ED9}. Note=Colocalizes with aggresomes, which are aggregates of misfolded proteins, at the centrosome. Also localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, multivesicular bodies (MVBs), lysosome, or mitochondria (By similarity). Often found in close association with microtubules (By similarity). Localizes to the manchette in elongating spermatids (PubMed:28003339). {ECO:0000250|UniProtKB:Q96ED9, ECO:0000269|PubMed:28003339}.
uniprot
proteins