TMEM86A
entrez
144110
canonical
uniprot
Q8N2M4
canonical
ensembl
ENSG00000151117
resolver
ensp
ENSP00000280734
resolver
enst
ENST00000280734
resolver
genesymbol
TMEM86A
resolver
hgnc
HGNC:26890
resolver
uniprot
Q96AJ0
resolver
uniprot_entry
TM86A_HUMAN
resolver
uniprot_sec
Q96AJ0
resolver
amino_acid_sequence
MVSPVTVVKSEGPKLVPFFKATCVYFVLWLPSSSPSWVSTLIKCLPIFCLWLFLLAHGLGFLLAHPSATRIFVGLVFSAVGDAFLIWQDQGYFVHGLLMFAVTHMFYASAFGMQPLALRTGLVMAALSGLCYALLYPCLSGAFTYLVGVYVALIGFMGWRAMAGLRLAGADWRWTELAAGSGALFFIISDLTIALNKFCFPVPYSRALIMSTYYVAQMLVALSAVESREPVEHYRLTKAN
uniprot
proteins
ec_number
3.3.2.2
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of the vinyl ether bond of choline or ethanolamine lysoplasmalogens, forming fatty aldehyde and glycerophosphocholine or glycerophosphoethanolamine, respectively and is specific for the sn-2-deacylated (lyso) form of plasmalogen (PubMed:36592658). Plays an important role in lysoplasmalogen metabolism in the adipocyte tissue and macrophages (PubMed:36592658). {ECO:0000269|PubMed:36592658}.
uniprot
proteins
mass_dalton
26398
uniprot
proteins
protein_family
TMEM86 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
36592658
uniprot
proteins
sequence_length
240
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9D8N3}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 44..64; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 71..91; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 93..113; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 116..136; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 139..159; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 175..195; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 207..227; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins