Tssk3
entrez
58864
canonical
uniprot
Q9D2E1
canonical
ensembl
ENSMUSG00000000411
resolver
ensp
ENSMUSP00000000421
resolver
enst
ENSMUST00000000421
resolver
genesymbol
Tssk3
resolver
genesymbol_syn
Stk22c
resolver
genesymbol_syn
Stk22d
resolver
uniprot
Q9JL98
resolver
uniprot_entry
TSSK3_MOUSE
resolver
uniprot_sec
Q9JL98
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation on Thr-168 by PDPK1. {ECO:0000269|PubMed:16336268}.
uniprot
proteins
amino_acid_sequence
MEDFLLSNGYQLGKTIGEGTYSKVKEAFSKKHQRKVAIKIIDKMGGPEEFIQRFLPRELQIVRTLDHKNIIQVYEMLESADGKIYLVMELAEGGDVFDCVLNGGPLPESRAKALFRQMVEAIRYCHGCGVAHRDLKCENALLQGFNLKLTDFGFAKVLPKSRRELSQTFCGSTAYAAPEVLQGIPHDSKKGDVWSMGVVLYVMLCASLPFDDTDIPKMLWQQQKGVSFPTHLGISTECQDLLKRLLEPDMILRPSIEEVSWHPWLAST
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine protein kinase required for spermatid development and male fertility. {ECO:0000269|PubMed:16336268, ECO:0000269|PubMed:34623009}.
uniprot
proteins
mass_dalton
30209
uniprot
proteins
mutagenesis
MUTAGEN 39; /note="K->R: Abolished serine/threonine protein kinase activity."; /evidence="ECO:0000269|PubMed:16336268"; MUTAGEN 166; /note="S->A: Abolished autophosphorylation."; /evidence="ECO:0000269|PubMed:16336268"; MUTAGEN 166; /note="S->D: Mimics phosphorylation, preventing autophosphorylation."; /evidence="ECO:0000269|PubMed:16336268"; MUTAGEN 168; /note="T->A: Abolished serine/threonine protein kinase activity."; /evidence="ECO:0000269|PubMed:16336268"; MUTAGEN 168; /note="T->D: Mimics phosphorylation; does not affect ability to autophosphorylate."; /evidence="ECO:0000269|PubMed:16336268
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated at Ser-166 (PubMed:16336268). Phosphorylation at Thr-168 by PDPK1 activates the serine/threonine protein kinase activity (PubMed:16336268). {ECO:0000269|PubMed:16336268}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10781952
uniprot
proteins
pubmed
11597141
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16336268
uniprot
proteins
pubmed
34623009
uniprot
proteins
sequence_length
268
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000269|PubMed:34623009}. Note=Localizes to the sperm flagellum in mature sperm. {ECO:0000269|PubMed:34623009}.
uniprot
proteins