Pcyox1l
entrez
240334
canonical
uniprot
Q8C7K6
canonical
ensembl
ENSMUSG00000024579
resolver
ensp
ENSMUSP00000025472
resolver
ensp
ENSMUSP00000315511
resolver
ensp
ENSMUSP00000315514
resolver
ensp
ENSMUSP00000315516
resolver
enst
ENSMUST00000025472
resolver
genesymbol
Pcyox1l
resolver
uniprot_entry
PCYXL_MOUSE
resolver
amino_acid_sequence
MARAAPLLAVLATVLTTAAAGGDAPPGKIAVIGAGIGGSAVAHFLQQHFGPRVQIVVYEKGTVGGRLATISVNKQNYESGAASFHSLSLHMQDFVKLLGLRQRREVVGRSAIFGGEHFVLEETDWYLLNLFRLWWYYGISFLRLQMWVEEVMEKFMRIYKYQAHGYAFSGVEELLYSLGEATFVNMTQRSVAESLLQVGVTQRFIDDVVSAVLRASYGQSASMPAFAGAMSLAGAQGNLWSVEGGNKLVCSGLLKLAKATVIHATVTSVTLHSTEGKALYQVAYESDKGNSSDFYDIVVIATPLHLDNSSNNNITFEGFTPPIEDIQGSFQPTVVSLVHGYLNSSYFGFPDPKLFPFANILTTDFPSFFCTLDNICPVNISASFRRKQPQEAAVWRVQSPKPLFRTELKTLFRSYYSVQTAEWQAHPLYGSRRTLPRFALHDQLFYLNALEWAASSVEVTAVAAKNVALLAYNRWYQDLDKIDQKDLIHKVKTEL
uniprot
proteins
ec_number
1.8.3.5
uniprot
proteins
function
FUNCTION: Prenylcysteine oxidase that cleaves the thioether bond of prenyl-L-cysteines, such as farnesylcysteine and geranylgeranylcysteine. Does not metabolize shorter prenyl chain compounds (By similarity). Required in the mevalonate pathway to regulate prenylation and enhances the bactericidal activity of neutrophils (PubMed:37179332). Promotes the assembly of the postsynaptic ion channel ASIC1a (By similarity). {ECO:0000250|UniProtKB:B5DEI0, ECO:0000250|UniProtKB:Q8NBM8, ECO:0000269|PubMed:37179332}.
uniprot
proteins
mass_dalton
54875
uniprot
proteins
protein_family
Prenylcysteine oxidase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
37179332
uniprot
proteins
pubmed
40712023
uniprot
proteins
sequence_length
495
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:B5DEI0}.
uniprot
proteins