P49891
uniprot
P49891
canonical
activity_regulation
ACTIVITY REGULATION: Inhibited by estradiol. {ECO:0000250|UniProtKB:P49888}.
uniprot
proteins
amino_acid_sequence
METSMPEYYEVFGEFRGVLMDKRFTKYWEDVEMFLARPDDLVIATYPKSGTTWISEVVYMIYKEGDVEKCKEDAIFNRIPYLECRNEDLINGIKQLKEKESPRIVKTHLPPKLLPASFWEKNCKMIYLCRNAKDVAVSYYYFLLMITSYPNPKSFSEFVEKFMQGQVPYGSWYDHVKAWWEKSKNSRVLFMFYEDMKEDIRREVVKLIEFLERKPSAELVDRIIQHTSFQEMKNNPSTNYTMMPEEMMNQKVSPFMRKGIIGDWKNHFPEALRERFDEHYKQQMKDCTVKFRMEL
uniprot
proteins
ec_number
2.8.2.4
uniprot
proteins
function
FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone (By similarity) (PubMed:9765259). Is a key enzyme in estrogen homeostasis, the sulfation of estrogens leads to their inactivation. Also sulfates dehydroepiandrosterone, pregnenolone, (24S)-hydroxycholesterol and xenobiotic compounds like ethinylestradiol, equalenin, diethyl stilbesterol and 1-naphthol at significantly lower efficiency. Does not sulfonate cortisol, testosterone and dopamine (By similarity). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system. {ECO:0000250|UniProtKB:P49888, ECO:0000269|PubMed:9765259}.
uniprot
proteins
mass_dalton
35590
uniprot
proteins
mutagenesis
MUTAGEN 48; /note="K->M: Loss of estrogen sulfotransferase activity."; /evidence="ECO:0000269|PubMed:9765259"; MUTAGEN 48; /note="K->R: Reduced estrogen sulfotransferase activity."; /evidence="ECO:0000269|PubMed:9765259"; MUTAGEN 106; /note="K->A: Strongly reduced estrogen sulfotransferase activity. Strongly reduced affinity for estradiol."; /evidence="ECO:0000269|PubMed:9765259"; MUTAGEN 106; /note="K->R,S: Strongly reduced estrogen sulfotransferase activity. Strongly reduced affinity for estradiol."; /evidence="ECO:0000269|PubMed:9765259"; MUTAGEN 108; /note="H->K,L,S,R: Loss of estrogen sulfotransferase activity."; /evidence="ECO:0000269|PubMed:9765259"; MUTAGEN 240; /note="Y->F: Slightly decreased estrogen sulfotransferase activity."; /evidence="ECO:0000269|PubMed:9765259
uniprot
proteins
protein_family
Sulfotransferase 1 family
uniprot
proteins
pubmed
7750469
uniprot
proteins
pubmed
9360604
uniprot
proteins
pubmed
9765259
uniprot
proteins
sequence_length
295
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P49887}.
uniprot
proteins