Dusp18
entrez
305477
canonical
uniprot
Q6AXW7
canonical
ensembl
ENSRNOG00000024945
resolver
ensp
ENSRNOP00000005516
resolver
enst
ENSRNOT00000005516
resolver
genesymbol
Dusp18
resolver
uniprot
F1LN58
resolver
uniprot_entry
DUS18_RAT
resolver
uniprot_entry
F1LN58_RAT
resolver
amino_acid_sequence
MTSPWSACPVQFPQPSISGLSQITKSLFISNGAAANDKLLLSSNQITTVINVSVEVANTFYEDIQYVQVPVVDAPIARLSDFFDPIADHIHSVEMKQGRTLLHCAAGVSRSAALCLAYLMKYHVMSLLDAHAWTKSRRPIIRPNSGFWEQLIHYEFQLFGKNTMQMVNSPMGLIPDIYEKETRMMIPLSTPDGAFHKGKEKALL
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP). In bone tissue, upon activation of the G(q)-dependent KISS1/KISS1R signaling pathway, DUSP18 is recruited to the KISS1R C-terminus, where it dephosphorylates SRC resulting in down-regulation of osteoclast differentiation and activity, and consequently suppression of bone resorption (By similarity). {ECO:0000250|UniProtKB:Q8NEJ0, ECO:0000250|UniProtKB:Q8VE01}.
uniprot
proteins
mass_dalton
22754
uniprot
proteins
protein_family
Non-receptor class dual specificity subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18385140
uniprot
proteins
sequence_length
204
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8VE01}. Nucleus {ECO:0000250|UniProtKB:Q8NEJ0}. Mitochondrion inner membrane {ECO:0000269|PubMed:18385140}; Peripheral membrane protein {ECO:0000269|PubMed:18385140}; Intermembrane side {ECO:0000269|PubMed:18385140}. Note=Translocates to cytoplasm in response to apoptotic stimuli such as staurosporine treatment. {ECO:0000250|UniProtKB:Q8VE01}.
uniprot
proteins