Ino80
entrez
68142
canonical
uniprot
Q6ZPV2
canonical
ensembl
ENSMUSG00000034154
resolver
ensp
ENSMUSP00000051845
resolver
genesymbol
Ino80
resolver
genesymbol_syn
Inoc1
resolver
genesymbol_syn
Kiaa1259
resolver
uniprot
A2AQP8
resolver
uniprot
Q6P7V0
resolver
uniprot
Q6PCP1
resolver
uniprot
Q8C9T7
resolver
uniprot_entry
INO80_MOUSE
resolver
uniprot_sec
A2AQP8
resolver
uniprot_sec
Q6P7V0
resolver
uniprot_sec
Q6PCP1
resolver
uniprot_sec
Q8C9T7
resolver
activity_regulation
ACTIVITY REGULATION: Activated upon binding to double stranded DNA or nucleosomes. {ECO:0000250|UniProtKB:Q9ULG1}.
uniprot
proteins
amino_acid_sequence
MASELGAGDDGSSTELAKPLYLQYLERALRLDHFLRQTSAIFNRNISSDDSEDGLDDNNPLLPESGDPLIQVKEEPPNSLLGETSGASSSGLLNPYSLNGVLQSESKSDKGNLYNFSKLKKSRKWLKSILLSDESSEADSQSEDNDDEEEELSLSREELHNMLRLHKYKKLHQNKYSKDKELQQYQYYSAGLLSTYDPFYEQQRHLLGPKKKKFKEDKKLKAKLKKVKKKRRRDEEFSSEESPRHHHHQTKVFAKFSHDAPPPGTKKKHLSIEQLNARRRKVWLSIVKKELPKANKQKSSARNLFLTNSRKLAHQCMKEVRRAALQAQKNCKETLPRARRLTKEMLLYWKKYEKVEKEHRKRAEKEALEQRKLDEEMREAKRQQRKLNFLITQTELYAHFMSRKRDMGHDGIQEEILRKLEDSSTQRQIDIGGGVVVNITQEDYDSNHFKAQALKNAENAYHIHQARTRSFDEDAKESRAAALRAADKSGSGFGESYSLANPSIRAGEDIPQPTIFNGKLKGYQLKGMNWLANLYEQGINGILADEMGLGKTVQSIALLAHLAERENIWGPFLIISPASTLNNWHQEFTRFVPKFKVLPYWGNPHDRKVIRRFWSQKTLYTQDAPFHVVITSYQLVVQDVKYFQRVKWQYMVLDEAQALKSSSSVRWKILLQFQCRNRLLLTGTPIQNTMAELWALLHFIMPTLFDSHEEFNEWFSKDIESHAENKSAIDENQLSRLHMILKPFMLRRIKKDVENELSDKIEILTYCQLTSRQKLLYQALKNKISIEDLLQSSMGSTQQAQNTTSSLMNLVMQFRKVCNHPELFERQETWSPFHISLKPYEISKFIYRHGQIRVFNHSRDRWLKVLLSPFAPDYIQQSLFHRKGINEGSCFSFLRFIDVSPAEMANLMLQGLLARWLALFLSLKASYRLHQLRSWAEPDGTSHQSYLRNKDFLLGVDFPLSFPNLCSCPLLKSLVFSSHCKAVSGYSDHVVHQRRSATSSLRCCLLTELPSFLCVASPRVTAVPLDSYCNDRSAEYERGVLKEGGSLAAKQCLLNGAPELATDWLSRRSQFFPEPAGGLLSIRPQNGWSFIRIPGKESLITDSGKLYALDVLLTRLKSQGHRVLIYSQMTRMIDLLEEYMVYRKHTYMRLDGSSKISERRDMVADFQTRNDIFVFLLSTRAGGLGINLTAADTVIFYDSDWNPTVDQQAMDRAHRLGQTKQVTVYRLICKGTIEERILQRAKEKSEIQRMVISGGNFKPDTLKPKEVVSLLLDDEELEKKLRLRQEEKRQQEESNRVKERKRKREKYAEKKKKEDELDGKRRKEGVNLVIPFVPSADNSNLSADGDDSFISVDSAMPSPFSEISISSELHTGSIPPDESSSDMLVIVDDPASSAPQSRATNSPASITGSVSDTVNGISIQEVPAAGRGHSARSRGRPKGSGSTAKGAGKGRSRKSTAGSAAAMAGAKAGAAAASAAAYAAYGYNVSKGISASSPLQTSIVRPAGLADFGPSSASSPLSSPLNKGNNIPGTPKSLHMTSSLASDSLIRKQGKGTNPSGGR
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: ATPase component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and DNA repair. Binds DNA. As part of the INO80 complex, remodels chromatin by shifting nucleosomes. Regulates transcription upon recruitment by YY1 to YY1-activated genes, where it acts as an essential coactivator. Involved in UV-damage excision DNA repair. The contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Involved in DNA replication. Required for microtubule assembly during mitosis thereby regulating chromosome segregation cycle. {ECO:0000250|UniProtKB:Q9ULG1}.
uniprot
proteins
mass_dalton
176520
uniprot
proteins
protein_family
SNF2/RAD54 helicase family
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16298340
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20971067
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1559
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9ULG1}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00746, ECO:0000269|PubMed:20971067}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9ULG1}. Chromosome {ECO:0000250|UniProtKB:Q9ULG1}. Note=Localizes to the cytoplasm in quiescent cell. Associates with spindle microtubules during mitosis. Colocalizes with PCNA at replication forks during S-phase. Recruited to DNA damage sites in a ACTR8-dependent manner. {ECO:0000250|UniProtKB:Q9ULG1}.
uniprot
proteins