Disp1
entrez
68897
canonical
uniprot
Q3TDN0
canonical
ensembl
ENSMUSG00000030768
resolver
ensp
ENSMUSP00000003035
resolver
ensp
ENSMUSP00000126742
resolver
ensp
ENSMUSP00000141747
resolver
ensp
ENSMUSP00000315486
resolver
genesymbol
Disp1
resolver
genesymbol_syn
Disp
resolver
genesymbol_syn
Dispa
resolver
genesymbol_syn
Icb
resolver
genesymbol_syn
Icbins
resolver
uniprot
Q3UUL8
resolver
uniprot
Q80ZZ8
resolver
uniprot
Q8CGS3
resolver
uniprot
Q8CIP6
resolver
uniprot
Q8CIQ9
resolver
uniprot
Q9CT62
resolver
uniprot_entry
DISP1_MOUSE
resolver
uniprot_sec
Q3UUL8
resolver
uniprot_sec
Q80ZZ8
resolver
uniprot_sec
Q8CGS3
resolver
uniprot_sec
Q8CIP6
resolver
uniprot_sec
Q8CIQ9
resolver
uniprot_sec
Q9CT62
resolver
amino_acid_sequence
MAVISGSDSVLLSNGSISTSTSNPSPLSPSDGDLPAQHLGPRETPRTKASPNGCLQLNGTVKSSFLPLDNQRTPQTPTQCCHPCPYHHPVSSHSNHQECHPEAGLAASPALASCRMQPHSEYSASLCPNHSPVYQAAHCLQPSPSFCLHHPWPDHFQHQPVRQHLTIIRPSRPFKFPRSYAALLADWPVVVLGMCTLLIVVCALVGVLVPELPDFSDPLLGFEPRGTTIGQRLVTWNNMMRNTGYKATLANYPYKYAEEQARSHRDDRWSDDHHERERREVDWNFQKDSFFCDVPSDGYSRVVFASAGGETLWNLPAIKSMCDVDNSRIRSHPQFSDLCQRTTAVSCCPSWTLGNYIAILNNRSSCQKIVERDVSHTLKLLRTCAKHYQNGTLGPDCWDKAARRKDQLKCTNVPRKCTKYNAVYQILHYLVDKDFMTPKTADYAVPALKYSMLFSPTEKGESMMNIYLDNFENWNSSDGITTVTGIEFGIKHSLFQDYLLMDTVYPAIAIAIVLLIMCVYTKSMFITLMTMFAIISSLIVSYFLYRVVFNFEFFPFMNLTALIILVGIGADDAFVLCDVWNYTKFDKPRAETSEAVSVTLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYAGTAILVNYVLMVTWLPAVIVLHERYLLNIFTCFRKPQPQAYDKSCWAVLCQKCRRVLFAVSEASRIFFEKVLPCIVIKFRYLWLIWFLALTVGGAYIVCVNPKMKLPSLELSEFQVFRSSHPFERYDAEFKKLFMFERVHHGEELHMPITVIWGVSPEDSGDPLNPKSKGELTLDSTFNIASPASQAWILHFCQKLRNQTFFHQTEQQDFTSCFIETFKQWMENQDCDEPALYPCCSHCSFPYKQEVFELCIKKAIMELDRSTGYHLNNKTPGPRFDINDTIRAVVLEFQSTFLFTLAYEKMQQFYKEVDSWISHELSSAPEGLSRGWFVSNLEFYDLQDSLSDGTLIAMGLSVAVAFSVMLLTTWNIIISLYAIVSIAGTIFVTVGSLVLLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRMGSAIAMAALTTFVAGAMMMPSTVLAYTQLGTFMMLVMCVSWAFATFFFQCLCRCLGPQGTCGQIPFPTKLQCSPFSHTLSARPGDRGPSKTHAASAYSVDARGQKSQLEHEFYELQPLASHSCTSSEKTTYEEPHTCSEFFNGQAKNLRMPVPAAYSSELTKSPSSEPGSALLQSCLEQDTVCHFSLNPRCNCRDAYTHLQYGLPEIHCQQMGDSLCHKCASTAGGFVQIQSSVAPLKASHQAAEGLLHPAQHMLPPGMQNSRPRNFFLHSVQHFQAQENLGRTSTHSTDERLPRTAELSPPPSDSRSTESFQRACCHPENNQRRLCKSRDPGDTEGSGGTKSKVSGLPNQTDKEEKQVEPSLLQTDETVNSEHLNHNESNFTFSHLPGEAGCRSCPNSPQSCRSIMRSKCGTEDCQTPNLEANVPAVPTHSDLSGESLLIKTL
uniprot
proteins
function
FUNCTION: Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion (PubMed:22902404). {ECO:0000269|PubMed:12372258, ECO:0000269|PubMed:12372301, ECO:0000269|PubMed:12421714, ECO:0000269|PubMed:19184110, ECO:0000269|PubMed:22902404}.
uniprot
proteins
mass_dalton
170130
uniprot
proteins
mutagenesis
MUTAGEN 158; /note="H->Y: No effect on the extracellular release of SHH."; /evidence="ECO:0000269|PubMed:19184110"; MUTAGEN 468; /note="L->S: No effect on the extracellular release of SHH."; /evidence="ECO:0000269|PubMed:19184110"; MUTAGEN 474..1521; /note="Missing: Impaired extracellular release of SHH."; /evidence="ECO:0000269|PubMed:19184110"; MUTAGEN 571..572; /note="DD->AA: Loss of function; when associated with A-1049."; /evidence="ECO:0000269|PubMed:12372301"; MUTAGEN 571..572; /note="DD->NN: Loss of function; when associated with N-1049."; /evidence="ECO:0000269|PubMed:12372301"; MUTAGEN 673; /note="Q->H: No effect on the extracellular release of SHH."; /evidence="ECO:0000269|PubMed:19184110"; MUTAGEN 732..1521; /note="Missing: Impaired extracellular release of SHH."; /evidence="ECO:0000269|PubMed:19184110"; MUTAGEN 814; /note="F->V: No effect on the extracellular release of SHH."; /evidence="ECO:0000269|PubMed:19184110"; MUTAGEN 829; /note="C->F: In icb; loss of function."; /evidence="ECO:0000269|PubMed:12372258"; MUTAGEN 926; /note="Q->R: No effect on the extracellular release of SHH."; /evidence="ECO:0000269|PubMed:19184110"; MUTAGEN 1049; /note="D->A: Loss of function; when associated with 571-A-A-572."; /evidence="ECO:0000269|PubMed:12372301"; MUTAGEN 1049; /note="D->N: Loss of function; when associated with 571-N-N-572."; /evidence="ECO:0000269|PubMed:12372301
uniprot
proteins
protein_family
Dispatched family
uniprot
proteins
pubmed
12372258
uniprot
proteins
pubmed
12372301
uniprot
proteins
pubmed
12421714
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19184110
uniprot
proteins
pubmed
22902404
uniprot
proteins
sequence_length
1521
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 189..209; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 499..519; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 524..544; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 548..568; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 603..623; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 637..657; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 717..737; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 986..1006; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1008..1028; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1038..1058; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1081..1101; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1109..1129; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins