Ddah2
entrez
51793
canonical
uniprot
Q99LD8
canonical
ensembl
ENSMUSG00000007039
resolver
ensp
ENSMUSP00000007255
resolver
ensp
ENSMUSP00000134072
resolver
ensp
ENSMUSP00000282356
resolver
ensp
ENSMUSP00000340985
resolver
enst
ENSMUST00000007255
resolver
enst
ENSMUST00000174493
resolver
genesymbol
Ddah2
resolver
uniprot
G3UYG1
resolver
uniprot
O08972
resolver
uniprot_entry
DDAH2_MOUSE
resolver
uniprot_entry
G3UYG1_MOUSE
resolver
uniprot_entry
O08972_MOUSE
resolver
amino_acid_sequence
MGTPGEGLGRCSHALIRGVPESLASGEGAGAGLPALDLAKAQREHGVLGGKLRQRLGLQLLELPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDGVRKALQDLGLRIVEMGDENATLDGTDVLFTGREFFVGLSKWTNHRGAEIVADTFRDFAVSTVPVSGSSHLRGLCGMGGPRTVVAGSSEAAQKAVRAMAALTDHPYASLTLPDDAASDCLFLRPGLPGATPFLLHRGGGDLPNSQEALQKLSDVTLVPVSCSELEKAGAGLSSLCLVLSTRPHC
uniprot
proteins
ec_number
3.-.-.-
uniprot
proteins
function
FUNCTION: Putative hydrolase with unknown substrate (Probable). Does not hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA) which acts as an inhibitor of NOS (PubMed:21493890, PubMed:37296100). In endothelial cells, induces expression of vascular endothelial growth factor (VEGF) via phosphorylation of the transcription factor SP1 by PKA in a process that is independent of NO and NO synthase (PubMed:16574895). Similarly, enhances pancreatic insulin secretion through SP1-mediated transcriptional up-regulation of secretagogin/SCGN, an insulin vesicle docking protein (PubMed:23430976). Upon viral infection, relocates to mitochondria where it promotes mitochondrial fission through activation of DNM1L leading to the inhibition of innate response activation mediated by MAVS (PubMed:33850055). {ECO:0000269|PubMed:16574895, ECO:0000269|PubMed:21493890, ECO:0000269|PubMed:23430976, ECO:0000269|PubMed:33850055, ECO:0000269|PubMed:37296100, ECO:0000305|PubMed:21493890, ECO:0000305|PubMed:37296100}.
uniprot
proteins
mass_dalton
29646
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by TBK1. Phosphorylation inhibits the translocation into the mitochondrion upon Sendai viral infection. {ECO:0000250|UniProtKB:O95865}.
uniprot
proteins
protein_family
DDAH family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16574895
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21493890
uniprot
proteins
pubmed
23430976
uniprot
proteins
pubmed
33850055
uniprot
proteins
pubmed
37296100
uniprot
proteins
sequence_length
285
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:33850055}. Mitochondrion {ECO:0000269|PubMed:33850055}. Note=Translocates from cytosol to mitochondrion upon IL1B stimulation in chondrocytes. {ECO:0000250|UniProtKB:O95865}.; SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:33850055}. Note=(Microbial infection) Translocates to the mitochondrion upon Sendai viral infection. {ECO:0000269|PubMed:33850055}.
uniprot
proteins