Eef2k
entrez
25435
canonical
uniprot
P70531
canonical
ensembl
ENSRNOG00000016448
resolver
ensembl
ENSRNOG00065031250
resolver
ensp
ENSRNOP00000022726
resolver
ensp
ENSRNOP00000107678
resolver
ensp
ENSRNOP00065044340
resolver
enst
ENSRNOT00000022726
resolver
enst
ENSRNOT00000150775
resolver
enst
ENSRNOT00065053902
resolver
genesymbol
Eef2k
resolver
uniprot
A0ABK0LAQ5
resolver
uniprot
O09089
resolver
uniprot_entry
A0ABK0LAQ5_RAT
resolver
uniprot_entry
EF2K_RAT
resolver
uniprot_sec
O09089
resolver
activity_regulation
ACTIVITY REGULATION: Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent. {ECO:0000269|PubMed:9144159}.
uniprot
proteins
amino_acid_sequence
MADEDLIFRLEGVDGGGSSGAGRHGDSDTDSDDDEGYFICPITDDHMSNQNVNSKGQGYYNNLLKTECGSTGSPASSFHFKEAWKHAIEKAKHMPDPWAEFHLEDIATEHATRHRYNAVTGEWLKDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQHWKGASNYVAKRYLEPVDRSVYFEDVQLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKDRQGQPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHTEKGTDFGDGNLGVRGMALFFYSHACNRICQSMGLAPFDLSPREQDAVNQSTKLLQSAKTILRGTEEKCGSPRIRTLSGSRPPLLLRLSENSGDENMSDVTFDSLPSSPSSATPHSQKLDHLHWPVFGDLDNMGPRDHDRMDNHRDSENSGDSGYPSEKRSDLDDPEPREHGHSNGNRRPESDEDSLGSSGRVCVETWNLLNPSRLHLPRPSAVALEVQRLNALDLGRKIGKSVLGKVHLAMVRYHEGGRFCEKDEEWDQESAIFHLEHAADLGELEAIVGLGLMYSQLPHHILADVSLEETEENKTKGFDYLLKAAEAGDRQSMILVARAFDTGLNLSPDRCQDWSEALHWYNTALETTDCDEGGEYDGIQDEPQYALLAREAEMLLTGGFGLDKNPQRSGDLYTQAAEAAMEAMKGRLANQYYEKAEEAWAQMEE
uniprot
proteins
ec_number
2.7.11.20
uniprot
proteins
function
FUNCTION: Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
81489
uniprot
proteins
post_translational_modification
PTM: The N-terminus is blocked.; PTM: Autophosphorylated at multiple residues, Thr-347 being the major site. Phosphorylated by AMP-activated protein kinase AMPK at Ser-397 leading to EEF2K activation and protein synthesis inhibition. Phosphorylated by TRPM7 at Ser-77 resulting in improved protein stability, higher EE2F phosphorylated and subsequently reduced rate of protein synthesis. Phosphorylation by other kinases such as CDK1 and MAPK13 at Ser-358 or RPS6KA1 and RPS6KB1 at Ser-365 instead decrease EEF2K activity and promote protein synthesis (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Alpha-type protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11171059
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8514778
uniprot
proteins
pubmed
8663182
uniprot
proteins
pubmed
9144159
uniprot
proteins
sequence_length
724
uniprot
proteins