Pjvk
entrez
381375
canonical
uniprot
Q0ZLH2
canonical
ensembl
ENSMUSG00000075267
resolver
ensp
ENSMUSP00000097566
resolver
enst
ENSMUST00000099986
resolver
genesymbol
Pjvk
resolver
genesymbol_syn
Dfnb59
resolver
genesymbol_syn
Gm1001
resolver
uniprot_entry
PJVK_MOUSE
resolver
amino_acid_sequence
MFAAATKSFVKQVGDGGRLVPVPSLSEADKYQPLSLVVKKKRCFLFPRCKFTSTPFTLKDILLGDREISAGISSYQLLNYEDESDVSLYGRRSNHIVNDVGINVTGSDSIAVKASFGVVTKHEVEVSTLLKEITARKINFDHSLIRQSRSSRKAVLCVVMESIRTTRQCSLSVHAGIRGEAMRFHFMDEQNPKGREKAIVFPAHTTIAFSVFELFIYLDGAFDICVTSVSKGGFEREETTTFAMFYRLRNILFERNRRVMDAISRSQLYLDDLFSDFYDKPLSMTDISLKEGTHIRVNLLNHNIPKGPCILCGMGNLKRETVYGCFQCSVDGVKYVRLHAVPCFDIWHKRMK
uniprot
proteins
function
FUNCTION: Peroxisome-associated protein required to protect auditory hair cells against noise-induced damage (PubMed:26544938, PubMed:30936319). Acts by regulating noise-induced peroxisome proliferation in auditory hair cells and neurons, and promoting autophagic degradation of damaged peroxisomes (pexophagy) (PubMed:26544938, PubMed:30936319). Noise overexposure increases reactive oxygen species (ROS) levels, causing oxidative damage to auditory hair cells and resulting in hearing loss (PubMed:30936319). PJVK acts as a ROS sensor that recruits the autophagy machinery to trigger pexophagy of peroxisomes damaged by oxidative stress (PubMed:30936319). In addition to pexophagy, also required to promote peroxisome proliferation in response to sound overstimulation (PubMed:26544938, PubMed:30936319). {ECO:0000269|PubMed:26544938, ECO:0000269|PubMed:30936319}.
uniprot
proteins
mass_dalton
39858
uniprot
proteins
mutagenesis
MUTAGEN 183; /note="R->W: Induces abnormal auditory brainstem responses indicative of neuronal dysfunction along the auditory pathway."; /evidence="ECO:0000269|PubMed:16804542"; MUTAGEN 309; /note="C->S: Does not affect interaction with MAP1LC3B."; /evidence="ECO:0000269|PubMed:30936319"; MUTAGEN 312; /note="C->S: Does not affect interaction with MAP1LC3B."; /evidence="ECO:0000269|PubMed:30936319"; MUTAGEN 325; /note="C->S: Does not affect interaction with MAP1LC3B."; /evidence="ECO:0000269|PubMed:30936319"; MUTAGEN 328; /note="C->S: Abolished interaction with MAP1LC3B and subsequent pexophagy."; /evidence="ECO:0000269|PubMed:30936319"; MUTAGEN 343; /note="C->S: Abolished interaction with MAP1LC3B and subsequent pexophagy."; /evidence="ECO:0000269|PubMed:30936319
uniprot
proteins
protein_family
Gasdermin family
uniprot
proteins
pubmed
16804542
uniprot
proteins
pubmed
17329413
uniprot
proteins
pubmed
26544938
uniprot
proteins
pubmed
28089576
uniprot
proteins
pubmed
28209736
uniprot
proteins
pubmed
30936319
uniprot
proteins
sequence_length
352
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:26544938}. Cell projection, cilium {ECO:0000269|PubMed:28209736}. Note=Associates with the peroxisomal membrane; it is unclear whether it is embedded or just associated with the peroxisomal membrane (PubMed:26544938). Localizes to ciliary rootlet (PubMed:28209736). {ECO:0000269|PubMed:26544938, ECO:0000269|PubMed:28209736}.
uniprot
proteins