Entpd8
entrez
72090
canonical
uniprot
Q8K0L2
canonical
ensembl
ENSMUSG00000036813
resolver
ensp
ENSMUSP00000110022
resolver
ensp
ENSMUSP00000223894
resolver
ensp
ENSMUSP00000223897
resolver
genesymbol
Entpd8
resolver
uniprot
A2AJ99
resolver
uniprot
Q6UQ22
resolver
uniprot_entry
ENTP8_MOUSE
resolver
uniprot_sec
A2AJ99
resolver
uniprot_sec
Q6UQ22
resolver
amino_acid_sequence
MGLSWKERVFMALLGVAAASGLTMLVLILVKAINVLLPADTKFGIVFDAGSSHTSLFVYQWPANKEKDTGVVSQALTCQIEGPGISSYTSDPTQAGESLKSCLEEALALIPQAQHPETPTFLGSTAGMRLLSQKNSSQARDILAAVSQTLSKSPVDFWGAKILAGQDEGAFGWITINYVLGMLLKYSSGQWILPEEGMLVGALDLGGASTQISFVPQGPILDQSTQVTFRLYGANYSVYTHSYLCFGRDQILNRLLAKLAQDRLSSQVAPVRHPCYHSGYQAILPLSSLYDSPCIHTTDSLNHTQNLTVEGTGDPGNCVVALRSLFNFSSCKGQKDCAFNGIYQPPVHGQFYAFSNFYYTFHFLNLTSRQSLNTVNDTVWKFCQKPWKLVEVSYPGQERWLRDYCASGLYILVLLLEGYKFSEETWPNIQFQKQAGDTDIGWTLGFMLNLTGMIPAEAPTHWRAQSYSIWTAGVVFAVLTLVAILGAAAIQIFWTQD
uniprot
proteins
ec_number
3.6.1.5
uniprot
proteins
function
FUNCTION: Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity (By similarity). Catalyzes the hydrolysis of nucleoside triphosphates (NTPs) and diphosphates (NDPs) (PubMed:15122917). The enzyme sequentially removes phosphate groups in two successive steps, converting NTPs to nucleoside monophosphates (NMPs) via NDP intermediates (PubMed:15122917). This activity contributes to the regulation of extracellular levels of nucleotides (PubMed:15122917). Hydrolyzes ATP, UTP, ADP, and UDP and prefers triphosphonucleosides and adenine over uracil as substrates. Does not hydrolyzes AMP (PubMed:15122917). {ECO:0000250|UniProtKB:Q5MY95, ECO:0000269|PubMed:15122917}.
uniprot
proteins
mass_dalton
54650
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q5MY95}.
uniprot
proteins
protein_family
GDA1/CD39 NTPase family
uniprot
proteins
pubmed
15122917
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
497
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5DRK1}; Multi-pass membrane protein {ECO:0000255}. Note=Localized in the canalicular membrane vesicle. {ECO:0000250|UniProtKB:Q5DRK1}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 474..494; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins