SGO1
entrez
151648
canonical
uniprot
Q5FBB7
canonical
ensembl
ENSG00000129810
resolver
ensp
ENSP00000263753
resolver
ensp
ENSP00000306581
resolver
ensp
ENSP00000389034
resolver
ensp
ENSP00000394613
resolver
ensp
ENSP00000394625
resolver
ensp
ENSP00000394957
resolver
ensp
ENSP00000410458
resolver
ensp
ENSP00000411200
resolver
ensp
ENSP00000413070
resolver
ensp
ENSP00000414129
resolver
ensp
ENSP00000414960
resolver
ensp
ENSP00000530204
resolver
ensp
ENSP00000594973
resolver
ensp
ENSP00000594975
resolver
ensp
ENSP00000594977
resolver
ensp
ENSP00000594979
resolver
genesymbol
SGO1
resolver
genesymbol
SGOL1
resolver
genesymbol_syn
SGOL1
resolver
hgnc
HGNC:25088
resolver
uniprot
A0A024R2K2
resolver
uniprot
B5BUA4
resolver
uniprot
Q588H5
resolver
uniprot
Q5FBB4
resolver
uniprot
Q5FBB5
resolver
uniprot
Q5FBB6
resolver
uniprot
Q5FBB8
resolver
uniprot
Q8N579
resolver
uniprot
Q8WVL0
resolver
uniprot
Q9BVA8
resolver
uniprot
Q9H275
resolver
uniprot_entry
B5BUA4_HUMAN
resolver
uniprot_entry
SGO1_HUMAN
resolver
uniprot_sec
A0A024R2K2
resolver
uniprot_sec
Q588H5
resolver
uniprot_sec
Q5FBB4
resolver
uniprot_sec
Q5FBB5
resolver
uniprot_sec
Q5FBB6
resolver
uniprot_sec
Q5FBB8
resolver
uniprot_sec
Q8N579
resolver
uniprot_sec
Q8WVL0
resolver
uniprot_sec
Q9BVA8
resolver
uniprot_sec
Q9H275
resolver
amino_acid_sequence
MAKERCLKKSFQDSLEDIKKRMKEKRNKNLAEIGKRRSFIAAPCQIITNTSTLLKNYQDNNKMLVLALENEKSKVKEAQDIILQLRKECYYLTCQLYALKGKLTSQQTVEPAQNQEICSSGMDPNSDDSSRNLFVKDLPQIPLEETELPGQGESFQIEDQIPTIPQDTLGVDFDSGEAKSTDNVLPRTVSVRSSLKKHCNSICQFDSLDDFETSHLAGKSFEFERVGFLDPLVNMHIPENVQHNACQWSKDQVNLSPKLIQPGTFTKTKEDILESKSEQTKSKQRDTQERKREEKRKANRRKSKRMSKYKENKSENKKTVPQKKMHKSVSSNDAYNFNLEEGVHLTPFRQKVSNDSNREENNESEVSLCESSGSGDDSDDLYLPTCKYIQNPTSNSDRPVTRPLAKRALKYTDEKETEGSKPTKTPTTTPPETQQSPHLSLKDITNVSLYPVVKIRRLSLSPKKNKASPAVALPKRRCTASVNYKEPTLASKLRRGDPFTDLCFLNSPIFKQKKDLRRSKKRALEVSPAKEAIFILYYVREFVSRFPDCRKCKLETHICLR
uniprot
proteins
disease_involvement
DISEASE: Chronic atrial and intestinal dysrhythmia (CAID) [MIM:616201]: A disease characterized by dysregulation of the cardiac sinus node resulting in sick sinus syndrome, in association with chronic intestinal pseudo-obstruction, a disorder of gastrointestinal motility in which intestinal obstruction occurs in the absence of a mechanical obstacle. {ECO:0000269|PubMed:25282101}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000269|PubMed:15604152, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:15737064, ECO:0000269|PubMed:16580887, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:17621308, ECO:0000269|PubMed:18331714, ECO:0000269|PubMed:20739936}.
uniprot
proteins
mass_dalton
64190
uniprot
proteins
mutagenesis
MUTAGEN 14; /note="S->A: Loss of phosphorylation and presence of misaligned chromosomes; when associated with A-507."; /evidence="ECO:0000269|PubMed:17621308"; MUTAGEN 61; /note="N->I: Loss of interaction with PPP2CA and PPP2R1A and loss of centromeric localization."; /evidence="ECO:0000269|PubMed:16580887"; MUTAGEN 73; /note="S->A: Loss of proper localization to spindle pole and mitotic spindle. Significant increase in split spindle poles."; /evidence="ECO:0000269|PubMed:18331714"; MUTAGEN 146; /note="T->A: Loss of proper localization to spindle pole and mitotic spindle. Significant increase in split spindle poles."; /evidence="ECO:0000269|PubMed:18331714"; MUTAGEN 451; /note="P->A: Disrupts interaction with CBX5, loss of localization to centromeres in interphase, no effect on localization to centromeres in mitosis; when associated with A-453 and A-455."; /evidence="ECO:0000269|PubMed:21346195"; MUTAGEN 453; /note="V->A: Disrupts interaction with CBX5, loss of localization to centromeres in interphase, no effect on localization to centromeres in mitosis; when associated with A-451 and A-455."; /evidence="ECO:0000269|PubMed:21346195"; MUTAGEN 455; /note="I->A: Disrupts interaction with CBX5, loss of localization to centromeres in interphase, no effect on localization to centromeres in mitosis; when associated with A-451 and A-453."; /evidence="ECO:0000269|PubMed:21346195"; MUTAGEN 492; /note="K->A: Loss of centromeric localization."; /evidence="ECO:0000269|PubMed:16580887"; MUTAGEN 507; /note="S->A: Loss of phosphorylation; and presence of misaligned chromosomes; when associated with A-14."; /evidence="ECO:0000269|PubMed:17621308
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1. {ECO:0000269|PubMed:19015261}.; PTM: Phosphorylation by NEK2 is essential for chromosome congression in mitosis and for the proper attachment of spindle microtubule to the kinetochore. Phosphorylated by PLK1 and AUKRB. {ECO:0000269|PubMed:16582621, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:17621308}.
uniprot
proteins
protein_family
Shugoshin family
uniprot
proteins
pubmed
12747765
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15604152
uniprot
proteins
pubmed
15723797
uniprot
proteins
pubmed
15737064
uniprot
proteins
pubmed
16541025
uniprot
proteins
pubmed
16580887
uniprot
proteins
pubmed
16582621
uniprot
proteins
pubmed
17617734
uniprot
proteins
pubmed
17621308
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18331714
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19015261
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20739936
uniprot
proteins
pubmed
21346195
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25282101
uniprot
proteins
pubmed
31429579
uniprot
proteins
sequence_length
561
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:16582621}. Chromosome, centromere {ECO:0000269|PubMed:15604152, ECO:0000269|PubMed:15723797, ECO:0000269|PubMed:16541025, ECO:0000269|PubMed:16580887, ECO:0000269|PubMed:21346195}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:16582621, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:17621308}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:16582621, ECO:0000269|PubMed:18331714}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18331714}. Nucleus speckle {ECO:0000269|PubMed:31429579}. Note=Localizes to the inner centromere throughout prophase until metaphase and disappears at anaphase (PubMed:16541025). Centromeric localization requires the presence of BUB1 and the interaction with PPP2R1A (PubMed:15604152, PubMed:16541025, PubMed:16580887). Colocalizes with NEK2 at the kinetochore (PubMed:17621308). Colocalizes with and SS18L1 at the kinetochore (PubMed:16582621). Phosphorylation by AUKRB and the presence of BUB1 are required for localization to the kinetochore (PubMed:17617734). Isoform 1 primarily localizes to kinetochores during G2 phase and mitotic prophase, metaphase, and anaphase and does not appear to be associated with kinetochores during late mitosis (PubMed:16582621). Isoform 3 is found at the centrosome in interphase and at spindle poles in mitosis and its spindle pole localization is PLK1 dependent (PubMed:16582621). Isoform 3 does not localize to kinetochores during any stages of the cell cycle (PubMed:16582621). {ECO:0000269|PubMed:15604152, ECO:0000269|PubMed:16541025, ECO:0000269|PubMed:16580887, ECO:0000269|PubMed:16582621, ECO:0000269|PubMed:17617734, ECO:0000269|PubMed:17621308}.
uniprot
proteins