CSNK1G2
entrez
1455
canonical
uniprot
P78368
canonical
ensembl
ENSG00000133275
resolver
ensp
ENSP00000255641
resolver
ensp
ENSP00000560404
resolver
ensp
ENSP00000560405
resolver
ensp
ENSP00000560406
resolver
ensp
ENSP00000605076
resolver
ensp
ENSP00000605077
resolver
ensp
ENSP00000605078
resolver
ensp
ENSP00000605079
resolver
ensp
ENSP00000605083
resolver
ensp
ENSP00000605084
resolver
ensp
ENSP00000619261
resolver
ensp
ENSP00000619262
resolver
ensp
ENSP00000619263
resolver
ensp
ENSP00000742203
resolver
enst
ENST00000255641
resolver
enst
ENST00000890345
resolver
enst
ENST00000890346
resolver
enst
ENST00000890347
resolver
enst
ENST00000935017
resolver
enst
ENST00000935018
resolver
enst
ENST00000935020
resolver
enst
ENST00000935024
resolver
enst
ENST00000935025
resolver
enst
ENST00000949202
resolver
enst
ENST00000949203
resolver
enst
ENST00000949204
resolver
genesymbol
CSNK1G2
resolver
genesymbol_syn
CK1G2
resolver
hgnc
HGNC:2455
resolver
uniprot
B5BU42
resolver
uniprot
O00704
resolver
uniprot
Q8WUB1
resolver
uniprot_entry
KC1G2_HUMAN
resolver
uniprot_sec
B5BU42
resolver
uniprot_sec
O00704
resolver
uniprot_sec
Q8WUB1
resolver
activity_regulation
ACTIVITY REGULATION: Stimulated by estrogen. Repressed by 5-iodotubercidin (DB04604). {ECO:0000269|PubMed:15077195}.
uniprot
proteins
amino_acid_sequence
MDFDKKGGKGETEEGRRMSKAGGGRSSHGIRSSGTSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRSGFVFDYEYDWAGKPLPTPIGTVHTDLPSQPQLRDKTQPHSKNQALNSTNGELNADDPTAGHSNAPITAPAEVEVADETKCCCFFKRRKRKSLQRHK
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation (PubMed:15077195, PubMed:15917222, PubMed:18794808, PubMed:19005213). Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate (By similarity). Involved in regulation of reactive oxygen species (ROS) levels (PubMed:37099597). {ECO:0000250|UniProtKB:P48729, ECO:0000250|UniProtKB:Q8BVP5, ECO:0000269|PubMed:15077195, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:18794808, ECO:0000269|PubMed:19005213, ECO:0000269|PubMed:37099597}.
uniprot
proteins
mass_dalton
47457
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated (PubMed:18794808). Phosphorylated by aPKC which promotes dissociation from the cell cortex (PubMed:26481050). {ECO:0000269|PubMed:18794808, ECO:0000269|PubMed:26481050}.
uniprot
proteins
protein_family
CK1 Ser/Thr protein kinase family
uniprot
proteins
protein_family
Casein kinase I subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15077195
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15917222
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
18794808
uniprot
proteins
pubmed
19005213
uniprot
proteins
pubmed
19054851
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26481050
uniprot
proteins
pubmed
37099597
uniprot
proteins
pubmed
9403068
uniprot
proteins
sequence_length
415
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cell cortex {ECO:0000269|PubMed:26481050}. Cytoplasm {ECO:0000269|PubMed:15077195, ECO:0000269|PubMed:26481050}.
uniprot
proteins