Trit1
entrez
66966
canonical
uniprot
Q80UN9
canonical
ensembl
ENSMUSG00000028653
resolver
ensp
ENSMUSP00000099709
resolver
ensp
ENSMUSP00000292977
resolver
genesymbol
Trit1
resolver
genesymbol_syn
Ipt
resolver
uniprot
B1ARS6
resolver
uniprot
Q9D1H5
resolver
uniprot_entry
MOD5_MOUSE
resolver
uniprot_sec
B1ARS6
resolver
uniprot_sec
Q9D1H5
resolver
amino_acid_sequence
MAAAAAARAVPVSSGFRGLRRTLPLVVILGATGTGKSTLALQLGQRLGGEIVSADSMQVYEGLDIITNKVSAQEQKMCQHHMISFVDPLVTSYTVVDFRNKATALIEDIFARDKIPIVVGGTNYYIESLLWKVLITTKPQEMGTGKVVDRKVELEKEDGHELHKRLSQVDPEMAAKLHPHDKRKVARSLQVFEETGISHSEFLHRQHAEEGGGPLGGPLRFPNPCILWLHADQAVLDERLDKRVDDMLAAGLLEELRGFHRRYNLKNISENSQDYQHGIFQSIGFKEFHEYLTTEGKCTPETSNQLLKKGIEALKQVTKRYARKQNRWVKNRFLSRPGPSVPPVYGLEVSDVSKWEESVLEPALNIVQSFIQGHKPTAMPVKMAYNESENKRSYHMCDLCDRIIIGDREWAAHLKSKSHLHQLKKRRRLDLDAVSATGSQSNSPDCDPERIEGESSGQHNQELKASV
uniprot
proteins
ec_number
2.5.1.75
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i6A37) (PubMed:23289710). Mediates modification of a limited subset of tRNAs: tRNA(Ser)(AGA), tRNA(Ser)(CGA), tRNA(Ser)(UGA), as well as partial modification of the selenocysteine tRNA(Ser)(UCA) (By similarity). TRIT1 is therefore required for selenoprotein expression (PubMed:23289710). {ECO:0000250|UniProtKB:Q9H3H1, ECO:0000269|PubMed:23289710}.
uniprot
proteins
mass_dalton
52437
uniprot
proteins
mutagenesis
MUTAGEN 32; /note="T->A: Reduced tRNA dimethylallyltransferase activity."; /evidence="ECO:0000269|PubMed:23289710"; MUTAGEN 55; /note="D->G: Reduced tRNA dimethylallyltransferase activity."; /evidence="ECO:0000269|PubMed:23289710
uniprot
proteins
protein_family
IPP transferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23289710
uniprot
proteins
sequence_length
467
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion {ECO:0000250|UniProtKB:Q9H3H1}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
uniprot
proteins