TUBA8
entrez
51807
canonical
uniprot
Q9NY65
canonical
ensembl
ENSG00000183785
resolver
ensp
ENSP00000318575
resolver
ensp
ENSP00000333326
resolver
genesymbol
TUBA8
resolver
genesymbol_syn
TUBAL2
resolver
hgnc
HGNC:12410
resolver
uniprot
B2RCX2
resolver
uniprot
B3KPW9
resolver
uniprot
B4DWG3
resolver
uniprot
Q2M3N4
resolver
uniprot_entry
TBA8_HUMAN
resolver
uniprot_sec
B2RCX2
resolver
uniprot_sec
B3KPW9
resolver
uniprot_sec
B4DWG3
resolver
uniprot_sec
Q2M3N4
resolver
amino_acid_sequence
MRECISVHVGQAGVQIGNACWELFCLEHGIQADGTFDAQASKINDDDSFTTFFSETGNGKHVPRAVMIDLEPTVVDEVRAGTYRQLFHPEQLITGKEDAANNYARGHYTVGKESIDLVLDRIRKLTDACSGLQGFLIFHSFGGGTGSGFTSLLMERLSLDYGKKSKLEFAIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLVTYAPIISAEKAYHEQLSVAEITSSCFEPNSQMVKCDPRHGKYMACCMLYRGDVVPKDVNVAIAAIKTKRTIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGTDSFEEENEGEEF
uniprot
proteins
disease_involvement
DISEASE: Macrothrombocytopenia, isolated, 2, autosomal dominant (MACTHC2) [MIM:619840]: A congenital blood disorder characterized by increased platelet size and decreased number of circulating platelets. Affected individuals usually are asymptomatic and do not have increased bleeding episodes. {ECO:0000269|PubMed:34704371}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
uniprot
proteins
mass_dalton
50094
uniprot
proteins
post_translational_modification
PTM: Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (PubMed:26875866). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (PubMed:26875866). Glutamylation is also involved in cilia motility (By similarity). {ECO:0000250|UniProtKB:P99024, ECO:0000269|PubMed:26875866}.; PTM: Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into cilia and flagella axonemes, which is required for their stability and maintenance. Flagella glycylation controls sperm motility. Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. {ECO:0000250|UniProtKB:P07437, ECO:0000305|PubMed:19524510}.; PTM: The C-terminal phenylalanine residue is cleaved by MATCAP1/KIAA0895L. {ECO:0000269|PubMed:35482892}.
uniprot
proteins
protein_family
Tubulin family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
10772959
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19524510
uniprot
proteins
pubmed
20466094
uniprot
proteins
pubmed
26875866
uniprot
proteins
pubmed
34704371
uniprot
proteins
pubmed
35482892
uniprot
proteins
sequence_length
449
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
uniprot
proteins