Atp1a3
entrez
24213
canonical
uniprot
P06687
canonical
ensembl
ENSRNOG00000020263
resolver
ensp
ENSRNOP00000027497
resolver
ensp
ENSRNOP00000105932
resolver
enst
ENSRNOT00000027497
resolver
genesymbol
Atp1a3
resolver
uniprot
A0A8L2QEN5
resolver
uniprot
Q16732
resolver
uniprot
Q9Z1G6
resolver
uniprot_entry
A0A8L2QEN5_RAT
resolver
uniprot_entry
AT1A3_RAT
resolver
uniprot_sec
Q16732
resolver
uniprot_sec
Q9Z1G6
resolver
activity_regulation
ACTIVITY REGULATION: Specifically inhibited by an endogenous cardiac glycoside, ouabain. {ECO:0000269|PubMed:2540801}.
uniprot
proteins
amino_acid_sequence
MGDKKDDKSSPKKSKAKERRDLDDLKKEVAMTEHKMSVEEVCRKYNTDCVQGLTHSKAQEILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAGTEDDPSGDNLYLGIVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDLVEIKGGDRVPADLRIISAHGCKVDNSSLTGESEPQTRSPDCTHDNPLETRNITFFSTNCVEGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVFLGVSFFILSLILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGTSFDKSSHTWVALSHIAGLCNRAVFKGGQDNIPVLKRDVAGDASESALLKCIELSSGSVKLMRERNKKVAEIPFNSTNKYQLSIHETEDPNDNRYLLVMKGAPERILDRCATILLQGKEQPLDEEMKEAFQNAYLELGGLGERVLGFCHYYLPEEQFPKGFAFDCDDVNFTTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIHGTDLKDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLISMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVNDLEDSYGQQWTYEQRKVVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSYCPGMDVALRMYPLKPSWWFCAFPYSFLIFVYDEIRKLILRRNPGGWVEKETYY
uniprot
proteins
ec_number
7.2.2.13
uniprot
proteins
function
FUNCTION: Neuron-specific alpha catalytic component of the Na(+)/K(+)-transporting ATPase, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (PubMed:2540801). Transports 3 Na(+) ions out of the cell and 2 K(+) ions into the cell for each ATP hydrolyze against their electrochemical gradients to maintain ion concentration gradients across the membranes. In the brain, ATP1A3 is critical for neuronal cell signaling and for maintenance of electrochemical stability, enabling cell excitation and action potential propagation (By similarity). {ECO:0000250|UniProtKB:P13637, ECO:0000269|PubMed:2540801}.
uniprot
proteins
mass_dalton
111692
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type IIC subfamily
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23532852
uniprot
proteins
pubmed
2540801
uniprot
proteins
pubmed
2822682
uniprot
proteins
pubmed
2822726
uniprot
proteins
pubmed
3028470
uniprot
proteins
sequence_length
1013
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P13637}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P13637}.
uniprot
proteins
transmembrane_region
TRANSMEM 91..107; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P13637"; TRANSMEM 119..139; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P13637"; TRANSMEM 282..303; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P13637"; TRANSMEM 307..345; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P13637"; TRANSMEM 767..786; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P13637"; TRANSMEM 794..809; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P13637"; TRANSMEM 840..862; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P13637"; TRANSMEM 905..927; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P13637"; TRANSMEM 943..966; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:P13637"; TRANSMEM 975..995; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:P13637
uniprot
proteins