PSMC2
entrez
5701
canonical
uniprot
P35998
canonical
ensembl
ENSG00000161057
resolver
ensp
ENSP00000292644
resolver
ensp
ENSP00000401724
resolver
genesymbol
PSMC2
resolver
genesymbol_syn
MSS1
resolver
hgnc
HGNC:9548
resolver
uniprot
A0A140VK70
resolver
uniprot
A4D0Q1
resolver
uniprot
B7Z571
resolver
uniprot
B7Z5E2
resolver
uniprot
Q3LIA5
resolver
uniprot
Q9UDI3
resolver
uniprot_entry
A0A140VK70_HUMAN
resolver
uniprot_entry
B7Z571_HUMAN
resolver
uniprot_entry
PRS7_HUMAN
resolver
uniprot_sec
A4D0Q1
resolver
uniprot_sec
B7Z5E2
resolver
uniprot_sec
Q3LIA5
resolver
uniprot_sec
Q9UDI3
resolver
amino_acid_sequence
MPDYLGADQRKTKEDEKDDKPIRALDEGDIALLKTYGQSTYSRQIKQVEDDIQQLLKKINELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIRVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSYAKFSATPRYMTYN
uniprot
proteins
function
FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:28539385, ECO:0000269|PubMed:9295362}.
uniprot
proteins
mass_dalton
48634
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated by RNF181. {ECO:0000269|PubMed:24811749}.; PTM: Phosphorylated (PubMed:28539385). Dephosphorylated by UBLCP1 which impairs PSMC2 ATPase activity and disrupts 26S proteasome assembly (PubMed:28539385). {ECO:0000269|PubMed:28539385}.
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
pubmed
10409732
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
12880961
uniprot
proteins
pubmed
1317798
uniprot
proteins
pubmed
1377363
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340068
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15831487
uniprot
proteins
pubmed
17323924
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22078707
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24811749
uniprot
proteins
pubmed
27342858
uniprot
proteins
pubmed
27428775
uniprot
proteins
pubmed
28539385
uniprot
proteins
pubmed
8500623
uniprot
proteins
pubmed
9295362
uniprot
proteins
sequence_length
433
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22078707}. Note=Colocalizes with TRIM5 in cytoplasmic bodies. {ECO:0000269|PubMed:22078707}.
uniprot
proteins