Trip13
entrez
69716
canonical
uniprot
Q3UA06
canonical
ensembl
ENSMUSG00000021569
resolver
ensp
ENSMUSP00000022053
resolver
ensp
ENSMUSP00000168727
resolver
genesymbol
Trip13
resolver
genesymbol_syn
Pch2
resolver
uniprot
A0JNT8
resolver
uniprot
Q05CL4
resolver
uniprot
Q3UQG6
resolver
uniprot
Q9CWW8
resolver
uniprot_entry
PCH2_MOUSE
resolver
uniprot_sec
A0JNT8
resolver
uniprot_sec
Q05CL4
resolver
uniprot_sec
Q3UQG6
resolver
uniprot_sec
Q9CWW8
resolver
amino_acid_sequence
MDEAVGDLKQALPCVAESPAVHVEVLQRSGSTAKKEDIKSSVYRLLNRHNIVFGDYVWTEFDDPFLSRNVQSVSIVDTELKAKDPQPIDLSACTIALHIFQLNEEGPSSENLDEETENIIAASHWVLPAAEFHGLWDSLVYDVEVKSHLLDYVMTTVLFSDKNVDSNLITWNRVVLLHGPPGTGKTSLCKALAQKLTIRLSSRYRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIQDLIDDKEALVFVLIDEVESLTAARNACRAGAEPSDAIRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVAFVDRADIKQYIGPPSAAAIFKIYLSCLEELMKCQIIYPRQQLLTLRELEMIGFIENNVSKLSLLLSEISRKSEGLSGRVLRKLPFLAHALYIQAPSVTIEGFLQALSLAVDKQFEEKKKLSAYV
uniprot
proteins
function
FUNCTION: Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (PubMed:17696610, PubMed:19851446, PubMed:20711356). Plays a role in mitotic spindle assembly checkpoint (SAC) activation (By similarity). {ECO:0000250|UniProtKB:Q15645, ECO:0000269|PubMed:17696610, ECO:0000269|PubMed:19851446, ECO:0000269|PubMed:20711356}.
uniprot
proteins
mass_dalton
48377
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
protein_family
PCH2 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17696610
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19851446
uniprot
proteins
pubmed
20711356
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31437213
uniprot
proteins
sequence_length
432
uniprot
proteins