Crmp1
entrez
12933
canonical
uniprot
P97427
canonical
ensembl
ENSMUSG00000029121
resolver
ensp
ENSMUSP00000031004
resolver
ensp
ENSMUSP00000109795
resolver
enst
ENSMUST00000031004
resolver
enst
ENSMUST00000114158
resolver
genesymbol
Crmp1
resolver
genesymbol_syn
Dpysl1
resolver
genesymbol_syn
Ulip3
resolver
uniprot
F6X8Y0
resolver
uniprot
O08554
resolver
uniprot
O35097
resolver
uniprot
Q6P1J1
resolver
uniprot_entry
DPYL1_MOUSE
resolver
uniprot_entry
F6X8Y0_MOUSE
resolver
uniprot_entry
Q6P1J1_MOUSE
resolver
uniprot_sec
O08554
resolver
uniprot_sec
O35097
resolver
amino_acid_sequence
MSHQGKKSIPHITSDRLLIRGGRIINDDQSFYADVYLEDGLIKQIGENLIVPGGVKTIEANGRMVIPGGIDVNTYLQKPSQGMTSADDFFQGTKAALAGGTTMIIDHVVPEPGSSLLTSFEKWHEAADTKSCCDYSLHVDITSWYDGVREELEVLVQDKGVNSFQVYMAYKDLYQMSDSQLYEAFTFLKGLGAVILVHAENGDLIAQEQKRILEMGITGPEGHALSRPEELEAEAVFRAIAIAGRINCPVYITKVMSKSAADIIALARKKGPLVFGEPIAASLGTDGTHYWSKNWAKAAAFVTSPPLSPDPTTPDYLTSLLACGDLQVTGSGHCPYSTAQKAVGKDNFTLIPEGVNGIEERMTVVWDKAVATGKMDENQFVAVTSTNAAKIFNLYPRKGRIAVGSDADVVIWDPDKMKTITAKSHKSTVEYNIFEGMECHGSPLVVISQGKIVFEDGNISVSKGMGRFIPRKPFPEHLYQRVRIRSKVFGLHSVSRGMYDGPVYEVPATPKHAAPAPSAKSSPSKHQPPPIRNLHQSNFSLSGAQIDDNNPRRTGHRIVAPPGGRSNITSLG
uniprot
proteins
function
FUNCTION: Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton (PubMed:14685275, PubMed:25358863). Plays a role in axon guidance (PubMed:14685275). During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone (PubMed:25358863). Involved in invasive growth and cell migration (By similarity). May participate in cytokinesis (By similarity). {ECO:0000250|UniProtKB:Q14194, ECO:0000269|PubMed:14685275, ECO:0000269|PubMed:25358863}.
uniprot
proteins
mass_dalton
62168
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-522 enhances CRMP1-mediated alteration of FLNA ternary structure and FLNA dissociation from F-actin. {ECO:0000250|UniProtKB:Q14194}.
uniprot
proteins
protein_family
Hydantoinase/dihydropyrimidinase family
uniprot
proteins
protein_family
Metallo-dependent hydrolases superfamily
uniprot
proteins
pubmed
10956643
uniprot
proteins
pubmed
14685275
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16800626
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25358863
uniprot
proteins
pubmed
9107681
uniprot
proteins
pubmed
9652388
uniprot
proteins
sequence_length
572
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q14194}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q14194}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q14194}. Cell projection, growth cone {ECO:0000269|PubMed:25358863}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:25358863}. Perikaryon {ECO:0000269|PubMed:14685275}. Note=Associated with centrosomes and the mitotic spindle during metaphase (By similarity). Colocalizes with FLNA and tubulin in the central region of DRG neuron growth cone (PubMed:25358863). Following SEMA3A stimulation of DRG neurons, colocalizes with F-actin (PubMed:25358863). {ECO:0000250|UniProtKB:Q14194, ECO:0000269|PubMed:25358863}.
uniprot
proteins