Kcnmb4
entrez
66016
canonical
uniprot
Q9ESK8
canonical
ensembl
ENSRNOG00000054458
resolver
ensembl
ENSRNOG00055012546
resolver
ensembl
ENSRNOG00060009578
resolver
ensembl
ENSRNOG00065013632
resolver
ensp
ENSRNOP00000075448
resolver
ensp
ENSRNOP00055017299
resolver
ensp
ENSRNOP00060012652
resolver
ensp
ENSRNOP00065017386
resolver
enst
ENSRNOT00000085579
resolver
enst
ENSRNOT00055021384
resolver
enst
ENSRNOT00060016179
resolver
enst
ENSRNOT00065022427
resolver
genesymbol
Kcnmb4
resolver
uniprot
B1WBP1
resolver
uniprot_entry
B1WBP1_RAT
resolver
uniprot_entry
KCMB4_RAT
resolver
amino_acid_sequence
MAKLRVSYEYTEAEDKSIRLGLFLIVSGILSLFIFGFCWLSPALQDLQATAANCTVLSVQQIGEVFECTFTCGTDCRGTSQYPCVQVYVNNSESNSRALLHSDQHQLLTNPKCSYIPPCKRENQKNSESVMNWQQYWKDEIGSQPFTCYFNQHQRPEDVLLQRTHDEIVLLHCFLWPVVAFVVGVLIVVLTICAKSLAVKAEAMKKRKFS
uniprot
proteins
function
FUNCTION: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
23885
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation modulates its effect on KCNMA1 activation kinetics (By similarity). {ECO:0000250}.; PTM: N-glycosylated. A highly glycosylated form is promoted by KCNMA1. Glycosylation, which is not required for the interaction with KCNMA1 and subcellular location, increases protection against charybdotoxin (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
KCNMB (TC 8.A.14.1) family
uniprot
proteins
protein_family
KCNMB4 subfamily
uniprot
proteins
sequence_length
210
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 20..40; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 168..188; /note="Helical; Name=2"; /evidence="ECO:0000255
uniprot
proteins