Arpin
entrez
70420
canonical
uniprot
Q9D0A3
canonical
ensembl
ENSMUSG00000039043
resolver
ensp
ENSMUSP00000049440
resolver
enst
ENSMUST00000048731
resolver
genesymbol
Arpin
resolver
uniprot
Q3U1F3
resolver
uniprot
Q8CA84
resolver
uniprot_entry
ARPIN_MOUSE
resolver
uniprot_sec
Q3U1F3
resolver
uniprot_sec
Q8CA84
resolver
amino_acid_sequence
MSRIYQDSALRNKAVQSARLPGTWDPATHQGGNGILLEGELVDVSRHSILDAHGRKERYYVLYIQPSCIHRRKFDPKGNEIEPNFSATRKVNTGFLMSSYKVEAKGDTDRLTLEALKSLVNKPQLLELTESLTPDQAVAFWMPESEMEVMELELGTGVRLKTRGDGPFIDSLAKLELGTVTKCNFAGDGKTGASWTDNIMAQKSSERNTAEIREQGDGAEDEEWDD
uniprot
proteins
function
FUNCTION: Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
25193
uniprot
proteins
protein_family
Arpin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24132237
uniprot
proteins
sequence_length
226
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, lamellipodium {ECO:0000269|PubMed:24132237}. Note=Colocalized with the WAVE complex at lamellipodium tip.
uniprot
proteins