Ifih1
entrez
71586
canonical
uniprot
Q8R5F7
canonical
ensembl
ENSMUSG00000026896
resolver
ensp
ENSMUSP00000028259
resolver
ensp
ENSMUSP00000108078
resolver
genesymbol
Ifih1
resolver
uniprot
A2AUY7
resolver
uniprot
D2CGM4
resolver
uniprot
Q3TGP5
resolver
uniprot
Q3U6S2
resolver
uniprot
Q68EM4
resolver
uniprot
Q8BYC9
resolver
uniprot
Q8BZ01
resolver
uniprot
Q8K5C7
resolver
uniprot
Q8R144
resolver
uniprot
Q8VE79
resolver
uniprot
Q99KS4
resolver
uniprot
Q9D2Z5
resolver
uniprot_entry
D2CGM4_MOUSE
resolver
uniprot_entry
IFIH1_MOUSE
resolver
uniprot_entry
Q3TGP5_MOUSE
resolver
uniprot_sec
A2AUY7
resolver
uniprot_sec
Q3U6S2
resolver
uniprot_sec
Q68EM4
resolver
uniprot_sec
Q8BYC9
resolver
uniprot_sec
Q8BZ01
resolver
uniprot_sec
Q8K5C7
resolver
uniprot_sec
Q8R144
resolver
uniprot_sec
Q8VE79
resolver
uniprot_sec
Q99KS4
resolver
uniprot_sec
Q9D2Z5
resolver
amino_acid_sequence
MSIVCSAEDSFRNLILFFRPRLKMYIQVEPVLDHLIFLSAETKEQILKKINTCGNTSAAELLLSTLEQGQWPLGWTQMFVEALEHSGNPLAARYVKPTLTDLPSPSSETAHDECLHLLTLLQPTLVDKLLINDVLDTCFEKGLLTVEDRNRISAAGNSGNESGVRELLRRIVQKENWFSTFLDVLRQTGNDALFQELTGGGCPEDNTDLANSSHRDGPAANECLLPAVDESSLETEAWNVDDILPEASCTDSSVTTESDTSLAEGSVSCFDESLGHNSNMGRDSGTMGSDSDESVIQTKRVSPEPELQLRPYQMEVAQPALDGKNIIICLPTGSGKTRVAVYITKDHLDKKKQASESGKVIVLVNKVMLAEQLFRKEFNPYLKKWYRIIGLSGDTQLKISFPEVVKSYDVIISTAQILENSLLNLESGDDDGVQLSDFSLIIIDECHHTNKEAVYNNIMRRYLKQKLRNNDLKKQNKPAIPLPQILGLTASPGVGAAKKQSEAEKHILNICANLDAFTIKTVKENLGQLKHQIKEPCKKFVIADDTRENPFKEKLLEIMASIQTYCQKSPMSDFGTQHYEQWAIQMEKKAAKDGNRKDRVCAEHLRKYNEALQINDTIRMIDAYSHLETFYTDEKEKKFAVLNDSDKSDDEASSCNDQLKGDVKKSLKLDETDEFLMNLFFDNKKMLKKLAENPKYENEKLIKLRNTILEQFTRSEESSRGIIFTKTRQSTYALSQWIMENAKFAEVGVKAHHLIGAGHSSEVKPMTQTEQKEVISKFRTGEINLLIATTVAEEGLDIKECNIVIRYGLVTNEIAMVQARGRARADESTYVLVTSSGSGVTEREIVNDFREKMMYKAINRVQNMKPEEYAHKILELQVQSILEKKMKVKRSIAKQYNDNPSLITLLCKNCSMLVCSGENIHVIEKMHHVNMTPEFKGLYIVRENKALQKKFADYQTNGEIICKCGQAWGTMMVHKGLDLPCLKIRNFVVNFKNNSPKKQYKKWVELPIRFPDLDYSEYCLYSDED
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and pro-inflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV), mengo encephalomyocarditis virus (ENMG), and theiler's murine encephalomyelitis virus (TMEV). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines. {ECO:0000269|PubMed:12015121, ECO:0000269|PubMed:16625202, ECO:0000269|PubMed:17942531, ECO:0000269|PubMed:19656871, ECO:0000269|PubMed:21217758}.
uniprot
proteins
mass_dalton
115971
uniprot
proteins
post_translational_modification
PTM: During apoptosis, processed into 3 cleavage products. The helicase-containing fragment, once liberated from the CARD domains, translocate from the cytoplasm to the nucleus. The processed protein significantly sensitizes cells to DNA degradation. {ECO:0000269|PubMed:12015121}.; PTM: Sumoylated. Sumoylation positively regulates its role in type I interferon induction and is enhanced by PIAS2-beta. {ECO:0000250|UniProtKB:Q9BYX4}.; PTM: Ubiquitinated by RNF125, leading to its degradation by the proteasome. USP17/UPS17L2-dependent deubiquitination positively regulates the receptor. Ubiquitinated by TRIM25 via 'Lys-63'-linked ubiquitination, promoting activation of IFIH1/MDA5. Ubiquitinated by TRIM40 via 'Lys-48'-linked ubiquitination; leading to proteasomal degradation. Ubiquitinated by TRIM65 via 'Lys-63'-linked ubiquitination, promoting activation of IFIH1/MDA5. {ECO:0000250|UniProtKB:Q9BYX4}.; PTM: ISGylated by ISG15. ISGylation increases upon infection with viruses. ISGylation at Lys-23 and Lys-43 is dependent of dephosphorylation, regulates mitochondrial translocation and oligomerization. Essential for IFIH1/MDA5-mediated cytokine responses and restriction of virus replication. {ECO:0000250|UniProtKB:Q9BYX4}.; PTM: Phosphorylated. Dephosphorylated by phsophatases PP1; dephosphorylation precedes and is required for ISGylation. {ECO:0000250|UniProtKB:Q9BYX4}.
uniprot
proteins
protein_family
Helicase family
uniprot
proteins
protein_family
RLR subfamily
uniprot
proteins
pubmed
11805321
uniprot
proteins
pubmed
12015121
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16625202
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17942531
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19656871
uniprot
proteins
pubmed
20950133
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21217758
uniprot
proteins
pubmed
21245900
uniprot
proteins
pubmed
21616437
uniprot
proteins
pubmed
21884169
uniprot
proteins
pubmed
22314235
uniprot
proteins
sequence_length
1025
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12015121}. Nucleus {ECO:0000250|UniProtKB:Q9BYX4}. Mitochondrion {ECO:0000250|UniProtKB:Q9BYX4}. Note=Upon viral RNA stimulation and ISGylation, translocates from cytosol to mitochondrion. May be found in the nucleus, during apoptosis. {ECO:0000250|UniProtKB:Q9BYX4}.
uniprot
proteins