QRICH1
entrez
54870
canonical
uniprot
Q2TAL8
canonical
ensembl
ENSG00000198218
resolver
ensp
ENSP00000350094
resolver
ensp
ENSP00000378830
resolver
ensp
ENSP00000412870
resolver
ensp
ENSP00000412890
resolver
ensp
ENSP00000515516
resolver
ensp
ENSP00000515573
resolver
ensp
ENSP00000557134
resolver
ensp
ENSP00000557135
resolver
ensp
ENSP00000557137
resolver
ensp
ENSP00000557138
resolver
ensp
ENSP00000557139
resolver
ensp
ENSP00000557140
resolver
ensp
ENSP00000557142
resolver
ensp
ENSP00000557144
resolver
ensp
ENSP00000609661
resolver
ensp
ENSP00000609666
resolver
ensp
ENSP00000609667
resolver
ensp
ENSP00000609668
resolver
ensp
ENSP00000641901
resolver
enst
ENST00000357496
resolver
enst
ENST00000395443
resolver
enst
ENST00000411682
resolver
enst
ENST00000424300
resolver
enst
ENST00000703871
resolver
enst
ENST00000703942
resolver
enst
ENST00000887075
resolver
enst
ENST00000887076
resolver
enst
ENST00000887078
resolver
enst
ENST00000887079
resolver
enst
ENST00000887080
resolver
enst
ENST00000887081
resolver
enst
ENST00000887083
resolver
enst
ENST00000887085
resolver
enst
ENST00000939602
resolver
enst
ENST00000939607
resolver
enst
ENST00000939608
resolver
enst
ENST00000939609
resolver
enst
ENST00000971842
resolver
genesymbol
QRICH1
resolver
hgnc
HGNC:24713
resolver
uniprot
A0A024R2T7
resolver
uniprot
A1L3Z7
resolver
uniprot
A1L3Z9
resolver
uniprot
Q4G0F7
resolver
uniprot
Q7L621
resolver
uniprot
Q8TEA5
resolver
uniprot_entry
A1L3Z9_HUMAN
resolver
uniprot_entry
QRIC1_HUMAN
resolver
uniprot_sec
A0A024R2T7
resolver
uniprot_sec
A1L3Z7
resolver
uniprot_sec
Q4G0F7
resolver
uniprot_sec
Q7L621
resolver
uniprot_sec
Q8TEA5
resolver
amino_acid_sequence
MNNSLENTISFEEYIRVKARSVPQHRMKEFLDSLASKGPEALQEFQQTATTTMVYQQGGNCIYTDSTEVAGSLLELACPVTTSVQPQTQQEQQIQVQQPQQVQVQVQVQQSPQQVSAQLSPQLTVHQPTEQPIQVQVQIQGQAPQSAAPSIQTPSLQSPSPSQLQAAQIQVQHVQAAQQIQAAEIPEEHIPHQQIQAQLVAGQSLAGGQQIQIQTVGALSPPPSQQGSPREGERRVGTASVLQPVKKRKVDMPITVSYAISGQPVATVLAIPQGQQQSYVSLRPDLLTVDSAHLYSATGTITSPTGETWTIPVYSAQPRGDPQQQSITHIAIPQEAYNAVHVSGSPTALAAVKLEDDKEKMVGTTSVVKNSHEEVVQTLANSLFPAQFMNGNIHIPVAVQAVAGTYQNTAQTVHIWDPQQQPQQQTPQEQTPPPQQQQQQLQVTCSAQTVQVAEVEPQSQPQPSPELLLPNSLKPEEGLEVWKNWAQTKNAELEKDAQNRLAPIGRRQLLRFQEDLISSAVAELNYGLCLMTREARNGEGEPYDPDVLYYIFLCIQKYLFENGRVDDIFSDLYYVRFTEWLHEVLKDVQPRVTPLGYVLPSHVTEEMLWECKQLGAHSPSTLLTTLMFFNTKYFLLKTVDQHMKLAFSKVLRQTKKNPSNPKDKSTSIRYLKALGIHQTGQKVTDDMYAEQTENPENPLRCPIKLYDFYLFKCPQSVKGRNDTFYLTPEPVVAPNSPIWYSVQPISREQMGQMLTRILVIREIQEAIAVANASTMH
uniprot
proteins
disease_involvement
DISEASE: Ververi-Brady syndrome 1 (VERBRAS1) [MIM:617982]: An autosomal dominant disorder characterized by mild developmental delay and intellectual disability, speech delay, learning difficulties, autistic features, and mild facial dysmorphism. {ECO:0000269|PubMed:28692176, ECO:0000269|PubMed:30281152, ECO:0000269|PubMed:33009816, ECO:0000269|PubMed:33738978, ECO:0000269|PubMed:34859529, ECO:0000269|PubMed:37211757, ECO:0000269|PubMed:37331002}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress (PubMed:33384352, PubMed:40355839). Controls the outcome of the unfolded protein response (UPR) which is an ER-stress response pathway (PubMed:33384352). ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR (PubMed:33384352). May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability (PubMed:33384352). Up-regulates CASP3/caspase-3 activity in epithelial cells under ER stress. Central regulator of proteotoxicity associated with ER stress-mediated inflammatory diseases in the intestines and liver (PubMed:33384352). Core component of the zincore complex, a heterotetramer that acts as a molecular 'grip' to stabilize transcription factors at DNA-binding sites across the genome, thereby controlling gene expression (PubMed:40608935). The zincore complex binds specifically to zinc finger transcription factors, such as ZFP91, ZNF652, ZNF526 and PRDM15, and stabilizes them onto their cognate DNA motif (PubMed:40608935). Involved in chondrocyte hypertrophy, a process required for normal longitudinal bone growth (PubMed:30281152). {ECO:0000269|PubMed:30281152, ECO:0000269|PubMed:33384352, ECO:0000269|PubMed:40355839, ECO:0000269|PubMed:40608935}.
uniprot
proteins
mass_dalton
86436
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28692176
uniprot
proteins
pubmed
30281152
uniprot
proteins
pubmed
33009816
uniprot
proteins
pubmed
33384352
uniprot
proteins
pubmed
33738978
uniprot
proteins
pubmed
34859529
uniprot
proteins
pubmed
37211757
uniprot
proteins
pubmed
37331002
uniprot
proteins
pubmed
40355839
uniprot
proteins
pubmed
40608935
uniprot
proteins
sequence_length
776
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:30281152, ECO:0000269|PubMed:33384352, ECO:0000269|PubMed:40608935}. Chromosome {ECO:0000269|PubMed:40608935}. Cytoplasm {ECO:0000269|PubMed:30281152}. Cell membrane {ECO:0000269|PubMed:30281152}. Note=The zincore complex binds to a highly conserved promoter motif (5'-CTTTAAR-3'). {ECO:0000269|PubMed:40608935}.
uniprot
proteins