Kcnk13
entrez
217826
canonical
uniprot
Q8R1P5
canonical
ensembl
ENSMUSG00000045404
resolver
ensp
ENSMUSP00000051846
resolver
ensp
ENSMUSP00000123916
resolver
ensp
ENSMUSP00000136882
resolver
ensp
ENSMUSP00000223502
resolver
ensp
ENSMUSP00000223508
resolver
enst
ENSMUST00000049788
resolver
enst
ENSMUST00000160413
resolver
enst
ENSMUST00000177549
resolver
genesymbol
Kcnk13
resolver
genesymbol_syn
Gm1570
resolver
uniprot
Q3TYG8
resolver
uniprot_entry
KCNKD_MOUSE
resolver
uniprot_entry
Q3TYG8_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Activated by anionic lipids (By similarity). Activated by arachidonic acid (By similarity). {ECO:0000250|UniProtKB:Q9HB14}.
uniprot
proteins
amino_acid_sequence
MAGRGCGCSPGHLNEDNARFLLLAGLILLYLLGGAAVFSALELAQELQAKQRWEERLANFSRGHNLSREELRGFLRHYEEATRAGIRMDSVRPRWDFTGAFYFVGTVVSTIGFGMTTPATTGGKIFLIFYGLIGCASTILFFNLFLERLITVIACVMRSCHQQQLRRRGAVTQDNMKAPEKGEADSLTGWKPSVYYVMLILCLASVAISCGASALYTTMEGWSYFDSVYFCFVAFSTIGFGDLVSSQNAQYESQGLYRFFNFFLILMGVCCIYSLFNVISILIKQTVNWILRKLDSGCFPPCQRGLLRSRRNVVMPGNIRNRCNISIETDGVMESDTDGRRLSGEMISMKDTNKVSLAILQKQLSEMANGGPHQNSASSRDDEFSGGVGAFAVMNNRLAETSGDR
uniprot
proteins
function
FUNCTION: K(+) channel that conducts outward rectifying tonic currents potentiated by purinergic signals (PubMed:38409076). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (By similarity). Contributes most of K(+) currents at the plasma membrane of resting microglia (By similarity). Maintains a depolarized membrane potential required for proper ramified microglia morphology and phagocytosis, selectively mediating microglial pruning of presynaptic compartments at hippocampal excitatory synapses (PubMed:29290552, PubMed:34642249). Upon local release of ATP caused by neuronal injury or infection, it is potentiated by P2RY12 and P2RX7 receptor signaling and contributes to ATP-triggered K(+) efflux underlying microglial NLRP3 inflammasome assembly and IL1B release (PubMed:29290552, PubMed:35353387, PubMed:38409076). {ECO:0000250|UniProtKB:Q9HB14, ECO:0000269|PubMed:29290552, ECO:0000269|PubMed:34642249, ECO:0000269|PubMed:35353387, ECO:0000269|PubMed:38409076}.
uniprot
proteins
mass_dalton
44926
uniprot
proteins
protein_family
Two pore domain potassium channel (TC 1.A.1.8) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
29290552
uniprot
proteins
pubmed
34642249
uniprot
proteins
pubmed
35353387
uniprot
proteins
pubmed
38409076
uniprot
proteins
sequence_length
405
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9HB14}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9HB14}.
uniprot
proteins
transmembrane_region
TRANSMEM 20..41; /note="Helical; Name=M1"; /evidence="ECO:0000250|UniProtKB:Q9HB14"; TRANSMEM 125..145; /note="Helical; Name=M2"; /evidence="ECO:0000250|UniProtKB:Q9HB14"; TRANSMEM 197..217; /note="Helical; Name=M3"; /evidence="ECO:0000250|UniProtKB:Q9HB14"; TRANSMEM 259..279; /note="Helical; Name=M4"; /evidence="ECO:0000250|UniProtKB:Q9HB14
uniprot
proteins