INHA
entrez
3623
canonical
uniprot
P05111
canonical
ensembl
ENSG00000123999
resolver
ensp
ENSP00000243786
resolver
enst
ENST00000243786
resolver
genesymbol
INHA
resolver
hgnc
HGNC:6065
resolver
uniprot
A8K8H5
resolver
uniprot_entry
INHA_HUMAN
resolver
uniprot_sec
A8K8H5
resolver
amino_acid_sequence
MVLHLLLFLLLTPQGGHSCQGLELARELVLAKVRALFLDALGPPAVTREGGDPGVRRLPRRHALGGFTHRGSEPEEEEDVSQAILFPATDASCEDKSAARGLAQEAEEGLFRYMFRPSQHTRSRQVTSAQLWFHTGLDRQGTAASNSSEPLLGLLALSPGGPVAVPMSLGHAPPHWAVLHLATSALSLLTHPVLVLLLRCPLCTCSARPEATPFLVAHTRTRPPSGGERARRSTPLMSWPWSPSALRLLQRPPEEPAAHANCHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIPPNLSLPVPGAPPTPAQPYSLLPGAQPCCAALPGTMRPLHVRTTSDGGYSFKYETVPNLLTQHCACI
uniprot
proteins
function
FUNCTION: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.; FUNCTION: Inhibin A is a dimer of alpha/INHA and beta-A/INHBA that functions as a feedback regulator in the hypothalamic-pituitary-gonadal (HPG) axis. Inhibits the secretion of FSH from the anterior pituitary gland by acting on pituitary gonadotrope cells. Antagonizes activin A by binding to the proteoglycan, betaglycan, and forming a stable complex with and, thereby, sequestering type II activin receptors while excluding type I receptor. {ECO:0000250|UniProtKB:P08476}.; FUNCTION: Inhibin B is a dimer of alpha and beta-B that plays a crucial role in the regulation of the reproductive system by inhibiting the secretion of follicle-stimulating hormone (FSH) from the anterior pituitary gland. Thereby, maintains reproductive homeostasis in both males and females. Acts as a more potent suppressor of FSH release than inhibin A (By similarity). Functions as competitive receptor antagonist binding activin type II receptors with high affinity in the presence of the TGF-beta type III coreceptor/TGFBR3L (PubMed:34910520). {ECO:0000250|UniProtKB:P17490, ECO:0000269|PubMed:11786387, ECO:0000269|PubMed:34910520}.
uniprot
proteins
mass_dalton
39670
uniprot
proteins
mutagenesis
MUTAGEN 56..57; /note="RR->AA: Loss of cleavage; when associated with 60-AA-61."; /evidence="ECO:0000269|PubMed:8885240"; MUTAGEN 60..61; /note="RR->AA: Loss of cleavage; when associated with 55-AA-56."; /evidence="ECO:0000269|PubMed:8885240"; MUTAGEN 231..232; /note="RR->EA: Loss of cleavage."; /evidence="ECO:0000269|PubMed:8885240"; MUTAGEN 268; /note="N->Q: Loss of glycosylation."; /evidence="ECO:0000269|PubMed:8885240"; MUTAGEN 302; /note="N->Q: Loss of glycosylation."; /evidence="ECO:0000269|PubMed:8885240
uniprot
proteins
post_translational_modification
PTM: Proteolytic processing yields a number of bioactive forms. The 20/23 kDa forms consist solely of the mature alpha chain, the 26/29 kDa forms consist of the most N-terminal propeptide linked through a disulfide bond to the mature alpha chain, the 50/53 kDa forms encompass the entire proprotein. Each type can be furthermore either mono- or diglycosylated, causing the mass difference. {ECO:0000269|PubMed:8885240}.
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
11098038
uniprot
proteins
pubmed
11786387
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24302632
uniprot
proteins
pubmed
3016724
uniprot
proteins
pubmed
34910520
uniprot
proteins
pubmed
3754442
uniprot
proteins
pubmed
3758355
uniprot
proteins
pubmed
8885240
uniprot
proteins
pubmed
9506758
uniprot
proteins
sequence_length
366
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P17490}.
uniprot
proteins