RAB5B
entrez
5869
canonical
uniprot
P61020
canonical
ensembl
ENSG00000111540
resolver
ensp
ENSP00000353444
resolver
ensp
ENSP00000391319
resolver
ensp
ENSP00000450168
resolver
ensp
ENSP00000580246
resolver
genesymbol
RAB5B
resolver
hgnc
HGNC:9784
resolver
uniprot
A8K982
resolver
uniprot
B4DKD7
resolver
uniprot
P35239
resolver
uniprot
P35277
resolver
uniprot
Q6PIK9
resolver
uniprot
Q86TH0
resolver
uniprot
Q8IXL2
resolver
uniprot_entry
RAB5B_HUMAN
resolver
uniprot_sec
A8K982
resolver
uniprot_sec
B4DKD7
resolver
uniprot_sec
P35239
resolver
uniprot_sec
P35277
resolver
uniprot_sec
Q6PIK9
resolver
uniprot_sec
Q86TH0
resolver
uniprot_sec
Q8IXL2
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP (Probable). Regulated by GTPase activating proteins (GAPs) including SGSM3, which increase the GTP hydrolysis activity (PubMed:16086013, PubMed:17562788). Inhibited by GDP dissociation inhibitors (GDIs) (Probable). {ECO:0000269|PubMed:16086013, ECO:0000269|PubMed:17562788, ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MTSRSTARPNGQPQASKICQFKLVLLGESAVGKSSLVLRFVKGQFHEYQESTIGAAFLTQSVCLDDTTVKFEIWDTAGQERYHSLAPMYYRGAQAAIVVYDITNQETFARAKTWVKELQRQASPSIVIALAGNKADLANKRMVEYEEAQAYADDNSLLFMETSAKTAMNVNDLFLAIAKKLPKSEPQNLGGAAGRSRGVDLHEQSQQNKSQCCSN
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:16086013, PubMed:17562788). Involved in early endocytic trafficking (PubMed:16086013, PubMed:17562788). Required for EEA1 recruitment to early endosomes (PubMed:16086013, PubMed:17562788). Required for EGF and transferrin endocytosis and trafficking through early endosomes (PubMed:16086013, PubMed:17562788). {ECO:0000269|PubMed:16086013, ECO:0000269|PubMed:17562788}.
uniprot
proteins
mass_dalton
23707
uniprot
proteins
mutagenesis
MUTAGEN 34; /note="S->N: Constitutively inactive (GDP-bound) mutant. Strongly reduces interaction with RIN2."; /evidence="ECO:0000269|PubMed:11733506"; MUTAGEN 79; /note="Q->L: Constitutively active (GTP-bound) mutant."; /evidence="ECO:0000269|PubMed:11733506"; MUTAGEN 84; /note="S->A: Loss of phosphorylation. No effect on GDI1, GDI2, CHML and CHM binding."; /evidence="ECO:0000269|PubMed:29125462"; MUTAGEN 84; /note="S->E: Phosphomimetic mutant. Loss of GDI1, GDI2, CHML and CHM binding."; /evidence="ECO:0000269|PubMed:29125462
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Ser-84 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2. {ECO:0000269|PubMed:29125462}.; PTM: (Microbial infection) Glycosylated on arginine residues by S.typhimurium protein Ssek3. {ECO:0000269|PubMed:32974215}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10491193
uniprot
proteins
pubmed
11733506
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
1541686
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16086013
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17081065
uniprot
proteins
pubmed
17562788
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29125462
uniprot
proteins
pubmed
32974215
uniprot
proteins
sequence_length
215
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17081065}; Lipid-anchor {ECO:0000269|PubMed:17081065}; Cytoplasmic side {ECO:0000269|PubMed:17081065}. Early endosome membrane {ECO:0000269|PubMed:17081065}; Lipid-anchor {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Enriched in stage I melanosomes. {ECO:0000269|PubMed:17081065}.
uniprot
proteins