Ttyh1
entrez
57776
canonical
uniprot
Q9D3A9
canonical
ensembl
ENSMUSG00000030428
resolver
ensp
ENSMUSP00000078384
resolver
ensp
ENSMUSP00000113937
resolver
ensp
ENSMUSP00000120182
resolver
ensp
ENSMUSP00000239728
resolver
ensp
ENSMUSP00000239791
resolver
genesymbol
Ttyh1
resolver
uniprot
Q6L751
resolver
uniprot
Q6P0A7
resolver
uniprot
Q8BRL4
resolver
uniprot
Q8C7M4
resolver
uniprot
Q9D5D1
resolver
uniprot
Q9EQN7
resolver
uniprot
Q9ESC3
resolver
uniprot_entry
TTYH1_MOUSE
resolver
uniprot_sec
Q6L751
resolver
uniprot_sec
Q6P0A7
resolver
uniprot_sec
Q8BRL4
resolver
uniprot_sec
Q8C7M4
resolver
uniprot_sec
Q9D5D1
resolver
uniprot_sec
Q9EQN7
resolver
uniprot_sec
Q9ESC3
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by (4-[(2-butyl-6,7-dichloro-2- cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]butanoic acid). {ECO:0000269|PubMed:31138989}.
uniprot
proteins
amino_acid_sequence
MGAPPGYRPSAWVHLLHQLPRADFQLRPVPSGFAPRDQEYQQALLLVAALAGLGLGLSLIFIAVYLIRFCCCRPPEPHGAKSPPPGGGCVTWSCIAALLVGCAGIGIGFYGNSETSDGVSQLSSALLHANHTLSTIDDVVLETVERLGEAVKTELTTLEEVLSVRMELVAATRGARRQAEAAAQYLQGLAFWQGVSLSPVQVAEDVTFVEEYRWLAYVLLLLLVLLVCLFTLLGLAKQSKWLVVVMTAMSLLVLVLSWGSMGLEAATAVGLSDFCSNPDTYVLNLTQEETGLSSDILSYYFLCNQAVSNPFQQRLTLSQRALASIHSQLQGLEREAIPQFSAAQKPLLSLEETLNVTERSFHQLVALLHCRSLHKDYGSALRGLCEDALEGLLFLMLFSLLSAGALATTLCSLPRAWALFPPSDDYDDTDDDDPFNPQESKRFVQWQSSI
uniprot
proteins
function
FUNCTION: Calcium-independent, swelling-dependent volume-regulated anion channel (VRAC-swell) which plays a pivotal role in the process of regulatory volume decrease (RVD) in the brain through the efflux of anions like chloride and organic osmolytes like glutamate. {ECO:0000269|PubMed:31138989}.
uniprot
proteins
mass_dalton
49032
uniprot
proteins
mutagenesis
MUTAGEN 165; /note="R->A: Significant decrease in hypo-osmotic solution-induced chloride conductance but no effect on cell membrane localization."; /evidence="ECO:0000269|PubMed:31138989
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. Contains high-mannose, hybrid and complex oligosaccharides. {ECO:0000250|UniProtKB:Q9H313}.
uniprot
proteins
protein_family
Tweety family
uniprot
proteins
pubmed
10950931
uniprot
proteins
pubmed
15010458
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
17116230
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31138989
uniprot
proteins
pubmed
36042377
uniprot
proteins
sequence_length
450
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:31138989, ECO:0000269|PubMed:36042377}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 44..64; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 89..109; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 215..235; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 241..261; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 391..411; /note="Helical; Name=5"; /evidence="ECO:0000255
uniprot
proteins