Chrna6
entrez
11440
canonical
uniprot
Q9R0W9
canonical
ensembl
ENSMUSG00000031491
resolver
ensp
ENSMUSP00000033882
resolver
enst
ENSMUST00000033882
resolver
genesymbol
Chrna6
resolver
genesymbol_syn
Nica6
resolver
uniprot
Q3UEY4
resolver
uniprot
Q8K0A7
resolver
uniprot_entry
ACHA6_MOUSE
resolver
uniprot_sec
Q3UEY4
resolver
uniprot_sec
Q8K0A7
resolver
activity_regulation
ACTIVITY REGULATION: Activated by a myriad of ligands such as acetylcholine, cytisine and nicotine (PubMed:12944511, PubMed:21325521, PubMed:24266758). CHRNA6 nAChR activity is inhibited by the antagonists alpha-conotoxin MII and PIA, a small disulfide-constrained peptides from cone snails (PubMed:21325521). {ECO:0000269|PubMed:12944511, ECO:0000269|PubMed:21325521, ECO:0000269|PubMed:24266758}.
uniprot
proteins
amino_acid_sequence
MLNSRDQGNLHSGLCLWLCGFLALFKGSTGCESEEQLFHRLFAHYNRFIRPVENVSDPVTVHFELAITQLANVDEVNQIMETNLWLRHIWKDYRLRWDPTEYDGIETLRVPADNIWKPDIVLYNNAVGDFQVEGKTKALLKYDGVITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIVDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPATHTMPKWVKTIFLQAFPSILMMRKPLDKTKEAGGVKDPKSHTKRPAKVKFTHRGESKLLKECHHCQKSSDIAPGKRRSSQQPARWVAENSEHSSDVEDVIESVQFIAENMKSHNETNEVEDDWKYMAMVVDRVFLWVFIIVCVFGTVGLFLQPLLGNTGKS
uniprot
proteins
function
FUNCTION: Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:12944511, PubMed:21325521, PubMed:22836257, PubMed:24266758). CHRNA6 forms pentameric channels with CHRNB2 and CHRNA4 that exhibit high sensitivity to ACh and nicotine and are predominantly expressed in only a few brain areas, including dopaminergic neurons, norepirephrine neurons and cells of the visual system (PubMed:12944511, PubMed:21325521, PubMed:22836257, PubMed:24266758). nAChrs containing CHRNA6 subunits mediate endogenous cholinergic modulation of dopamine and gamma-aminobutyric acid (GABA) release in response to nicotine at nerve terminals (PubMed:12944511, PubMed:21325521, PubMed:22836257, PubMed:24266758). {ECO:0000269|PubMed:12944511, ECO:0000269|PubMed:21325521, ECO:0000269|PubMed:22836257, ECO:0000269|PubMed:24266758}.
uniprot
proteins
mass_dalton
56856
uniprot
proteins
mutagenesis
MUTAGEN 280; /note="L->S: Increases sensitivity to agonists such as acetylcholine or nicotine. Alterates dopamine synthesis. Increases locomotor activation in animals with this mutation. Promotes drug reward."; /evidence="ECO:0000269|PubMed:24266758
uniprot
proteins
protein_family
Acetylcholine receptor (TC 1.A.9.1) subfamily
uniprot
proteins
protein_family
Alpha-6/CHRNA6 sub-subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
12944511
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21325521
uniprot
proteins
pubmed
22836257
uniprot
proteins
pubmed
24266758
uniprot
proteins
sequence_length
494
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Synaptic cell membrane {ECO:0000269|PubMed:12944511, ECO:0000269|PubMed:21325521, ECO:0000269|PubMed:22836257}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 241..265; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 272..290; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 306..327; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 466..485; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins