TBRG1
entrez
84897
canonical
uniprot
Q3YBR2
canonical
ensembl
ENSG00000154144
resolver
ensp
ENSP00000409016
resolver
ensp
ENSP00000659549
resolver
genesymbol
TBRG1
resolver
genesymbol_syn
NIAM
resolver
hgnc
HGNC:29551
resolver
uniprot
Q53GJ5
resolver
uniprot
Q66ZJ6
resolver
uniprot
Q69YS7
resolver
uniprot
Q8TCS4
resolver
uniprot
Q8TEI4
resolver
uniprot
Q96SV0
resolver
uniprot_entry
TBRG1_HUMAN
resolver
uniprot_sec
Q53GJ5
resolver
uniprot_sec
Q66ZJ6
resolver
uniprot_sec
Q69YS7
resolver
uniprot_sec
Q8TCS4
resolver
uniprot_sec
Q8TEI4
resolver
uniprot_sec
Q96SV0
resolver
amino_acid_sequence
MSLLDGLASSPRAPLQSSKARMKKLPKKSQNEKYRLKYLRLRKAAKATVFENAAICDEIARLEEKFLKAKEERRYLLKKLLQLQALTEGEVQAAAPSHSSSLPLTYGVASSVGTIQGAGPISGPSTGAEEPFGKKTKKEKKEKGKENNKLEVLKKTCKKKKMAGGARKLVQPIALDPSGRPVFPIGLGGLTVYSLGEIITDRPGFHDESAIYPVGYCSTRIYASMKCPDQKCLYTCQIKDGGVQPQFEIVPEDDPQNAIVSSSADACHAELLRTISTTMGKLMPNLLPAGADFFGFSHPAIHNLIQSCPGARKCINYQWVKFDVCKPGDGQLPEGLPENDAAMSFEAFQRQIFDEDQNDPLLPGSLDLPELQPAAFVSSYQPMYLTHEPLVDTHLQHLKSPSQGSPIQSSD
uniprot
proteins
function
FUNCTION: Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in maintaining chromosomal stability. {ECO:0000269|PubMed:17110379}.
uniprot
proteins
mass_dalton
44946
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; mediated by MDM2 and leading to its subsequent proteasomal degradation. {ECO:0000269|PubMed:17110379}.
uniprot
proteins
protein_family
TBRG1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16582619
uniprot
proteins
pubmed
17110379
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20506279
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
411
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17110379}.
uniprot
proteins