Lypla1
entrez
18777
canonical
uniprot
P97823
canonical
ensembl
ENSMUSG00000025903
resolver
ensp
ENSMUSP00000027036
resolver
ensp
ENSMUSP00000111191
resolver
enst
ENSMUST00000115529
resolver
genesymbol
Lypla1
resolver
genesymbol_syn
Apt1
resolver
genesymbol_syn
Pla1a
resolver
uniprot
D3Z111
resolver
uniprot
Q3TJZ0
resolver
uniprot
Q7TPX1
resolver
uniprot
Q8BWM6
resolver
uniprot_entry
D3Z111_MOUSE
resolver
uniprot_entry
LYPA1_MOUSE
resolver
uniprot_sec
Q3TJZ0
resolver
uniprot_sec
Q7TPX1
resolver
uniprot_sec
Q8BWM6
resolver
amino_acid_sequence
MCGNNMSAPMPAVVPAARKATAAVIFLHGLGDTGHGWAEAFAGIKSPHIKYICPHAPVMPVTLNMNMAMPSWFDIVGLSPDSQEDESGIKQAAETVKALIDQEVKNGIPSNRIILGGFSQGGALSLYTALTTQQKLAGVTALSCWLPLRASFSQGPINSANRDISVLQCHGDCDPLVPLMFGSLTVERLKALINPANVTFKIYEGMMHSSCQQEMMDVKHFIDKLLPPID
uniprot
proteins
ec_number
3.1.2.-
uniprot
proteins
ec_number
3.1.2.22
uniprot
proteins
function
FUNCTION: Acts as an acyl-protein thioesterase (By similarity). Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS (By similarity). Acts as a palmitoyl thioesterase that catalyzes depalmitoylation of proteins, such as ADRB2, KCNMA1 and SQSTM1 (By similarity). Acts as a negative regulator of autophagy by mediating palmitoylation of SQSTM1, decreasing affinity between SQSTM1 and ATG8 proteins and recruitment of ubiquitinated cargo proteins to autophagosomes (By similarity). Acts as a lysophospholipase and hydrolyzes lysophosphatidylcholine (lyso-PC) (By similarity). Also hydrolyzes lysophosphatidylethanolamine (lyso-PE), lysophosphatidylinositol (lyso-PI) and lysophosphatidylserine (lyso-PS) (PubMed:9139730). Has much higher thioesterase activity than lysophospholipase activity (By similarity). Contributes to the production of lysophosphatidic acid (LPA) during blood coagulation by recognizing and cleaving plasma phospholipids to generate lysophospholipids which in turn act as substrates for ENPP2 to produce LPA (By similarity). {ECO:0000250|UniProtKB:O75608, ECO:0000250|UniProtKB:P70470, ECO:0000269|PubMed:9139730}.
uniprot
proteins
mass_dalton
24688
uniprot
proteins
mutagenesis
MUTAGEN 119; /note="S->A: Abolishes lysophospholipase activity."; /evidence="ECO:0000269|PubMed:9139730"; MUTAGEN 174; /note="D->A: Abolishes lysophospholipase activity."; /evidence="ECO:0000269|PubMed:9268342"; MUTAGEN 208; /note="H->A: Abolishes lysophospholipase activity."; /evidence="ECO:0000269|PubMed:9268342
uniprot
proteins
protein_family
AB hydrolase 2 family
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
9139730
uniprot
proteins
pubmed
9268342
uniprot
proteins
sequence_length
230
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O75608}. Cell membrane {ECO:0000250|UniProtKB:O75608}. Nucleus membrane {ECO:0000250|UniProtKB:O75608}. Endoplasmic reticulum {ECO:0000250|UniProtKB:O75608}. Note=Shows predominantly a cytoplasmic localization with a weak expression in the cell membrane, nuclear membrane and endoplasmic reticulum. {ECO:0000250|UniProtKB:O75608}.
uniprot
proteins