AKR1B10
entrez
57016
canonical
uniprot
O60218
canonical
ensembl
ENSG00000198074
resolver
ensp
ENSP00000352584
resolver
ensp
ENSP00000568909
resolver
ensp
ENSP00000643136
resolver
ensp
ENSP00000763892
resolver
enst
ENST00000359579
resolver
genesymbol
AKR1B10
resolver
genesymbol_syn
AKR1B11
resolver
hgnc
HGNC:382
resolver
uniprot
A4D1P1
resolver
uniprot
O75890
resolver
uniprot
Q6FHF3
resolver
uniprot
Q8IWZ1
resolver
uniprot_entry
AK1BA_HUMAN
resolver
uniprot_sec
A4D1P1
resolver
uniprot_sec
O75890
resolver
uniprot_sec
Q6FHF3
resolver
uniprot_sec
Q8IWZ1
resolver
activity_regulation
ACTIVITY REGULATION: Retinaldehyde reductase activity is inhibited by tolrestat. {ECO:0000269|PubMed:12732097, ECO:0000269|PubMed:18087047}.
uniprot
proteins
amino_acid_sequence
MATFVELSTKAKMPIVGLGTWKSPLGKVKEAVKVAIDAGYRHIDCAYVYQNEHEVGEAIQEKIQEKAVKREDLFIVSKLWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKSGDDLFPKDDKGNAIGGKATFLDAWEAMEELVDEGLVKALGVSNFSHFQIEKLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTAAQVLIRFHIQRNVIVIPKSVTPARIVENIQVFDFKLSDEEMATILSFNRNWRACNVLQSSHLEDYPFNAEY
uniprot
proteins
ec_number
1.1.1.300
uniprot
proteins
ec_number
1.1.1.54
uniprot
proteins
function
FUNCTION: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:12732097, PubMed:18087047, PubMed:19013440, PubMed:19563777, PubMed:9565553). Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:18087047). Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:19013440, PubMed:19563777). Displays no reductase activity towards glucose (PubMed:12732097). {ECO:0000269|PubMed:12732097, ECO:0000269|PubMed:18087047, ECO:0000269|PubMed:19013440, ECO:0000269|PubMed:19563777, ECO:0000269|PubMed:9565553}.
uniprot
proteins
mass_dalton
36020
uniprot
proteins
mutagenesis
MUTAGEN 125; /note="K->L: Increased affinity and reduced catalytic activity towards all-trans-retinaldehyde."; /evidence="ECO:0000269|PubMed:18087047"; MUTAGEN 299; /note="C->S: Decreased affinity and reduced catalytic activity towards 4-hydroxynonenal."; /evidence="ECO:0000269|PubMed:19013440"; MUTAGEN 301; /note="V->L: Reduced catalytic activity towards all-trans-retinaldehyde."; /evidence="ECO:0000269|PubMed:18087047
uniprot
proteins
pathway_participation
PATHWAY: Cofactor metabolism; retinol metabolism. {ECO:0000269|PubMed:12732097, ECO:0000269|PubMed:18087047}.
uniprot
proteins
protein_family
Aldo/keto reductase family
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12732097
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15755999
uniprot
proteins
pubmed
18087047
uniprot
proteins
pubmed
19013440
uniprot
proteins
pubmed
19563777
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21585341
uniprot
proteins
pubmed
9537432
uniprot
proteins
pubmed
9565553
uniprot
proteins
pubmed
9765596
uniprot
proteins
sequence_length
316
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:21585341}. Secreted {ECO:0000269|PubMed:21585341}. Note=Secreted through a lysosome-mediated non-classical pathway.
uniprot
proteins