Fem1a
entrez
316131
canonical
uniprot
Q4V890
canonical
ensembl
ENSRNOG00000066151
resolver
ensembl
ENSRNOG00055015251
resolver
ensembl
ENSRNOG00060019318
resolver
ensembl
ENSRNOG00065013637
resolver
ensp
ENSRNOP00000091315
resolver
ensp
ENSRNOP00000100872
resolver
ensp
ENSRNOP00000103653
resolver
ensp
ENSRNOP00000105715
resolver
ensp
ENSRNOP00000106988
resolver
ensp
ENSRNOP00000111720
resolver
ensp
ENSRNOP00055021222
resolver
ensp
ENSRNOP00060027311
resolver
ensp
ENSRNOP00065017393
resolver
enst
ENSRNOT00000099590
resolver
enst
ENSRNOT00000123425
resolver
enst
ENSRNOT00000132217
resolver
enst
ENSRNOT00000135814
resolver
enst
ENSRNOT00000146209
resolver
enst
ENSRNOT00000153920
resolver
enst
ENSRNOT00055026060
resolver
enst
ENSRNOT00060033378
resolver
enst
ENSRNOT00065022434
resolver
genesymbol
Fem1a
resolver
uniprot_entry
FEM1A_RAT
resolver
amino_acid_sequence
MDLHTAVYNAAHDGKLLLLQKLLAGRGREEIEELLGEVAGGGTPLLIAARRGHLDVVEYLVDNCGASVEASGSVHFDGETIEGAPPLWAASAAGHLAVVRSLLRRGASVNRTTRTNSTPLRAACFDGHLDVVRYLVGEHKADLEVANRHGHTCLMISCYKGHREIARYLLERGAQVNRRSAKGNTALHDCAESGSLEILQLLLGCHARMERDGYGMTPLLAASVTGHTNIVEYLIQEQPGHGQLSGTELPGEGSSQMAGNHCSTPEEAEPYESCCPTSREAAVEALELLGATYVDKKRDLLGALKHWRRAMELRHQGGDYLPKPEPQQLVLAYDYSREVSTPQELEALITDPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFERCIRLWKYALDMQQNNLEPLSPMTASSFLSFAELFSYVLQDRSAKGNLGMQLGFADLMGVLSKGVREVERALQLPKEPGDSAQFTKAIAIILHLLYLLEKVECTPSQEHLKHQTVYRLLKCAPRGKNGFTPLHMAVDKETTNVGRYRVGIFPSLQVVKVLLDCGADPDSRDFDNNTPLHVAAQNNCPAIMDALIEAGAHMDATNAFKKTAYELLDSKLLAKSTMQPFNYVTLQCLAARALDRNKVPYKGFIPEELEAFIQLH
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL2(FEM1A) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation (By similarity). Involved in PGE2-EP4-mediated inhibition of inflammation of macrophages via interaction with NFKB1 and PTGER4. Promotes inflammation in brain microglia through MAP2K4/MKK4-mediated signaling (By similarity). {ECO:0000250|UniProtKB:Q9BSK4, ECO:0000250|UniProtKB:Q9Z2G1}.
uniprot
proteins
mass_dalton
72118
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9BSK4}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated; highly phosphorylated in myoblasts and myotubes. Phosphorylation at Ser-108 and Ser-608 promote PGE2-EP4-mediated inhibition of inflammation. Dephosphorylated by protein phosphatase 2A (PP2A). {ECO:0000250|UniProtKB:Q9Z2G1}.
uniprot
proteins
protein_family
Fem-1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
654
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9BSK4}. Cytoplasm {ECO:0000250|UniProtKB:Q9BSK4}.
uniprot
proteins