Cldn19
entrez
242653
canonical
uniprot
Q9ET38
canonical
ensembl
ENSMUSG00000066058
resolver
ensp
ENSMUSP00000081334
resolver
ensp
ENSMUSP00000092418
resolver
genesymbol
Cldn19
resolver
uniprot
Q3UNX6
resolver
uniprot
Q8R4B7
resolver
uniprot_entry
CLD19_MOUSE
resolver
uniprot_entry
Q3UNX6_MOUSE
resolver
uniprot_sec
Q8R4B7
resolver
amino_acid_sequence
MANSGLQLLGYFLALGGWVGIIASTALPQWKQSSYAGDAIITAVGLYEGLWMSCASQSTGQVQCKLYDSLLALDGHIQSARALMVVAVLLGFVAMVLSVVGMKCTRVGDSNPTAKSRVAISGGALFLLAGLCTLTAVSWYATLVTQEFFNPSTPVNARYEFGPALFVGWASAGLAMLGGSFLCCTCPEPERANSIPQPYRSGPSTAAREPVVKLPASVKGPLGV
uniprot
proteins
function
FUNCTION: Forms paracellular channels: coassembles with CLDN16 into tight junction strands with cation-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability (By similarity) (PubMed:19706394). Involved in the maintenance of ion gradients along the nephron. In the thick ascending limb (TAL) of Henle's loop, facilitates sodium paracellular permeability from the interstitial compartment to the lumen, contributing to the lumen-positive transepithelial potential that drives paracellular magnesium and calcium reabsorption (PubMed:28028216). Forms paracellular barriers on its own. In the peripheral nervous system, represents a major constituent of the tight junctions in Schwann cells and contributes to electrical sealing. During retinal neurogenesis, may regulate the barrier properties of tight junctions in retinal pigment epithelium, required for proper retinal tissue differentiation and vision (PubMed:15883201, PubMed:30937396). {ECO:0000250|UniProtKB:Q8N6F1, ECO:0000269|PubMed:15883201, ECO:0000269|PubMed:19706394, ECO:0000269|PubMed:28028216, ECO:0000269|PubMed:30937396}.
uniprot
proteins
mass_dalton
23343
uniprot
proteins
mutagenesis
MUTAGEN 35; /note="Y->F: No effect on interaction with Clostridium perfringens CPE."; /evidence="ECO:0000269|PubMed:25678664"; MUTAGEN 35; /note="Y->S: Abolishes interaction with Clostridium perfringens CPE."; /evidence="ECO:0000269|PubMed:25678664"; MUTAGEN 38; /note="D->A: No effect on interaction with Clostridium perfringens CPE."; /evidence="ECO:0000269|PubMed:25678664"; MUTAGEN 39; /note="A->R: Abolishes interaction with Clostridium perfringens CPE."; /evidence="ECO:0000269|PubMed:25678664"; MUTAGEN 39; /note="A->S: Strongly reduces interaction with Clostridium perfringens CPE."; /evidence="ECO:0000269|PubMed:25678664"; MUTAGEN 40; /note="I->A,S,L: Abolishes interaction with Clostridium perfringens CPE."; /evidence="ECO:0000269|PubMed:25678664"; MUTAGEN 40; /note="I->V: Strongly reduces interaction with Clostridium perfringens CPE."; /evidence="ECO:0000269|PubMed:25678664"; MUTAGEN 41; /note="I->A,S,V: Abolishes interaction with Clostridium perfringens CPE."; /evidence="ECO:0000269|PubMed:25678664"; MUTAGEN 41; /note="I->L: No effect on interaction with Clostridium perfringens CPE."; /evidence="ECO:0000269|PubMed:25678664"; MUTAGEN 42; /note="T->A,V: No effect on interaction with Clostridium perfringens CPE."; /evidence="ECO:0000269|PubMed:25678664"; MUTAGEN 53; /note="S->A: No effect on interaction with Clostridium perfringens CPE."; /evidence="ECO:0000269|PubMed:25678664"; MUTAGEN 146; /note="Q->A: No effect on interaction with Clostridium perfringens CPE."; /evidence="ECO:0000269|PubMed:25678664"; MUTAGEN 147; /note="E->A,Q,R: No effect on interaction with Clostridium perfringens CPE."; /evidence="ECO:0000269|PubMed:25678664"; MUTAGEN 150; /note="N->A,D,Q,K: Abolishes interaction with Clostridium perfringens CPE."; /evidence="ECO:0000269|PubMed:25678664"; MUTAGEN 150; /note="N->S,L: Strongly inhibits interaction with Clostridium perfringens CPE."; /evidence="ECO:0000269|PubMed:25678664"; MUTAGEN 151; /note="P->A,G: Abolishes interaction with Clostridium perfringens CPE."; /evidence="ECO:0000269|PubMed:25678664"; MUTAGEN 152; /note="S->D: Abolishes interaction with Clostridium perfringens CPE."; /evidence="ECO:0000269|PubMed:25678664"; MUTAGEN 152; /note="S->L,M,F: No effect on interaction with Clostridium perfringens CPE."; /evidence="ECO:0000269|PubMed:25678664"; MUTAGEN 153; /note="T->V,L: No effect on interaction with Clostridium perfringens CPE."; /evidence="ECO:0000269|PubMed:25678664"; MUTAGEN 153; /note="T->Y: Abolishes interaction with Clostridium perfringens CPE."; /evidence="ECO:0000269|PubMed:25678664"; MUTAGEN 154; /note="P->A: Strongly inhibits interaction with Clostridium perfringens CPE."; /evidence="ECO:0000269|PubMed:25678664"; MUTAGEN 154; /note="P->D: Abolishes interaction with Clostridium perfringens CPE."; /evidence="ECO:0000269|PubMed:25678664"; MUTAGEN 155; /note="V->I: No effect on interaction with Clostridium perfringens CPE."; /evidence="ECO:0000269|PubMed:25678664"; MUTAGEN 156; /note="N->A,S: No effect on interaction with Clostridium perfringens CPE."; /evidence="ECO:0000269|PubMed:25678664"; MUTAGEN 156; /note="N->G: Strongly inhibits interaction with Clostridium perfringens CPE."; /evidence="ECO:0000269|PubMed:25678664"; MUTAGEN 159; /note="Y->S,F: Strongly inhibits interaction with Clostridium perfringens CPE."; /evidence="ECO:0000269|PubMed:25678664
uniprot
proteins
protein_family
Claudin family
uniprot
proteins
pubmed
15883201
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19706394
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25678664
uniprot
proteins
pubmed
28028216
uniprot
proteins
pubmed
30937396
uniprot
proteins
sequence_length
224
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000269|PubMed:25678664, ECO:0000269|PubMed:28028216}. Cell membrane {ECO:0000269|PubMed:25678664}; Multi-pass membrane protein {ECO:0000269|PubMed:25678664}. Note=Cotrafficks with CLDN16 from ER to tight junctions. Colocalizes with CLDN16 and CLDN3 in cell-cell contact areas of the TAL spatially separated from CLDN10b paracellular channels. {ECO:0000250|UniProtKB:Q8N6F1, ECO:0000269|PubMed:28028216}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 82..102; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 118..138; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 161..181; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins