Pgam5
entrez
72542
canonical
uniprot
Q8BX10
canonical
ensembl
ENSMUSG00000029500
resolver
ensp
ENSMUSP00000057760
resolver
ensp
ENSMUSP00000108124
resolver
genesymbol
Pgam5
resolver
uniprot
B2RSM6
resolver
uniprot
Q3UK19
resolver
uniprot
Q80VY8
resolver
uniprot
Q8BM78
resolver
uniprot
Q9CZU2
resolver
uniprot_entry
PGAM5_MOUSE
resolver
uniprot_sec
B2RSM6
resolver
uniprot_sec
Q3UK19
resolver
uniprot_sec
Q80VY8
resolver
uniprot_sec
Q8BM78
resolver
uniprot_sec
Q9CZU2
resolver
amino_acid_sequence
MAFRQALQLAACGLAGGSAAVLFSAVAVGKPRGGGDADTRATEPPAWTGARAGRGVWDTNWDRREPLSLINLKKRNVESGEDELTSRLDHYKAKATRHIFLIRHSQYHVDGSLEKDRTLTPLGREQAELTGLRLASLGLKFNKIVHSSMTRAVETTDIISKHLPGVSRVSTDLLREGAPIEPDPPVSHWKPEAVQYYEDGARIEAAFRNYIHRADARQEEDSYEIFICHANVIRYIVCRALQFPPEGWLRLSLNNGSITHLVIRPNGRVALRTLGDTGFMPPDKITRS
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Mitochondrial serine/threonine phosphatase that dephosphorylates various substrates and thus plays a role in different biological processes including cellular senescence or mitophagy. Modulates cellular senescence by regulating mitochondrial dynamics. Mechanistically, participates in mitochondrial fission through dephosphorylating DNM1L/DRP1. Additionally, dephosphorylates MFN2 in a stress-sensitive manner and consequently protects it from ubiquitination and degradation to promote mitochondrial network formation. Regulates mitophagy independent of PARKIN by interacting with and dephosphorylating FUNDC1, which interacts with LC3. Regulates anti-oxidative response by forming a tertiary complex with KEAP1 and NRF2 (By similarity). Regulates necroptosis by acting as a RIPK3 target and recruiting the RIPK1-RIPK3-MLKL necrosis 'attack' complex to mitochondria (PubMed:22265414). {ECO:0000250|UniProtKB:Q96HS1, ECO:0000269|PubMed:22265414}.
uniprot
proteins
mass_dalton
31994
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by the RIPK1/RIPK3 complex under necrotic conditions. This phosphorylation increases PGAM5 phosphatase activity (By similarity). {ECO:0000250}.; PTM: Proteolytically cleaved by PARL in response to loss of mitochondrial membrane potential. {ECO:0000250|UniProtKB:Q96HS1}.; PTM: Ubiquitinated by the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex composed of at least CUL3, KLHL6 and RBX1; leading to proteasomal degradation. {ECO:0000250|UniProtKB:O94900}.
uniprot
proteins
protein_family
BPG-dependent PGAM subfamily
uniprot
proteins
protein_family
Phosphoglycerate mutase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22265414
uniprot
proteins
pubmed
32439975
uniprot
proteins
sequence_length
288
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q96HS1}; Single-pass membrane protein {ECO:0000255}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q96HS1}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..29; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins