CABYR
entrez
26256
canonical
uniprot
O75952
canonical
ensembl
ENSG00000154040
resolver
ensp
ENSP00000317095
resolver
ensp
ENSP00000382404
resolver
ensp
ENSP00000382419
resolver
ensp
ENSP00000382421
resolver
ensp
ENSP00000399973
resolver
ensp
ENSP00000483621
resolver
ensp
ENSP00000486801
resolver
enst
ENST00000627314
resolver
genesymbol
CABYR
resolver
genesymbol_syn
CBP86
resolver
genesymbol_syn
FSP2
resolver
hgnc
HGNC:15569
resolver
uniprot
A0A024RC21
resolver
uniprot
A0A0D9SFQ2
resolver
uniprot
B2R857
resolver
uniprot
B4DXA8
resolver
uniprot
Q8WXW5
resolver
uniprot
Q9HAY3
resolver
uniprot
Q9HAY4
resolver
uniprot
Q9HAY5
resolver
uniprot
Q9HCY9
resolver
uniprot_entry
A0A024RC21_HUMAN
resolver
uniprot_entry
A0A0D9SFQ2_HUMAN
resolver
uniprot_entry
B4DXA8_HUMAN
resolver
uniprot_entry
CABYR_HUMAN
resolver
uniprot_sec
B2R857
resolver
uniprot_sec
Q8WXW5
resolver
uniprot_sec
Q9HAY3
resolver
uniprot_sec
Q9HAY4
resolver
uniprot_sec
Q9HAY5
resolver
uniprot_sec
Q9HCY9
resolver
amino_acid_sequence
MISSKPRLVVPYGLKTLLEGISRAVLKTNPSNINQFAAAYFQELTMYRGNTTMDIKDLVKQFHQIKVEKWSEGTTPQKKLECLKEPGKTSVESKVPTQMEKSTDTDEDNVTRTEYSDKTTQFPSVYAVPGTEQTEAVGGLSSKPATPKTTTPPSSPPPTAVSPEFAYVPADPAQLAAQMLGKVSSIHSDQSDVLMVDVATSMPVVIKEVPSSEAAEDVMVAAPLVCSGKVLEVQVVNQTSVHVDLGSQPKENEAEPSTASSVPLQDEQEPPAYDQAPEVTLQADIEVMSTVHISSVYNDVPVTEGVVYIEQLPEQIVIPFTDQVACLKENEQSKENEQSPRVSPKSVVEKTTSGMSKKSVESVKLAQLEENAKYSSVYMEAEATALLSDTSLKGQPEVPAQLLDAEGAIKIGSEKSLHLEVEITSIVSDNTGQEESGENSVPQEMEGKPVLSGEAAEAVHSGTSVKSSSGPFPPAPEGLTAPEIEPEGESTAE
uniprot
proteins
function
FUNCTION: May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium.
uniprot
proteins
mass_dalton
52774
uniprot
proteins
mutagenesis
MUTAGEN 146; /note="T->A: Does not affect phosphorylation."; /evidence="ECO:0000269|PubMed:15752768"; MUTAGEN 151; /note="T->A: Decreases phosphorylation. Abolishes phosphorylation; when associated with A-155."; /evidence="ECO:0000269|PubMed:15752768"; MUTAGEN 154; /note="S->A: Does not affect phosphorylation. Does not affect phosphorylation; when associated with A-159."; /evidence="ECO:0000269|PubMed:15752768"; MUTAGEN 155; /note="S->A: Decreases phosphorylation and interaction with GSK3B. Abolishes phosphorylation and decreases interaction with GSK3B; when associated with A-151."; /evidence="ECO:0000269|PubMed:15752768"; MUTAGEN 159; /note="T->A: Does not affect phosphorylation. Does not affect phosphorylation; when associated with A-154."; /evidence="ECO:0000269|PubMed:15752768
uniprot
proteins
post_translational_modification
PTM: Isoform 1 is phosphorylated on tyrosine residues during in vitro capacitation. Isoform 3 and isoform 5 are phosphorylated by GSK3B in vitro. Dephosphorylation affects its ability to bind calcium. {ECO:0000269|PubMed:11820818, ECO:0000269|PubMed:15752768}.
uniprot
proteins
pubmed
11820818
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15752768
uniprot
proteins
pubmed
16139264
uniprot
proteins
pubmed
16177791
uniprot
proteins
sequence_length
493
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum. Note=Localized to fibrous sheath including the surface of the longitudinal columns and ribs of the principal piece of sperm flagella.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus. Cytoplasm. Cell projection, cilium, flagellum. Note=According to PubMed:15752768, isoform 1, isoform 3 and isoform 5 are both nuclear and cytoplasmic.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus. Cytoplasm. Cell projection, cilium, flagellum. Note=According to PubMed:15752768, isoform 1, isoform 3 and isoform 5 are both nuclear and cytoplasmic.; SUBCELLULAR LOCATION: [Isoform 5]: Nucleus. Cytoplasm. Cell projection, cilium, flagellum. Note=According to PubMed:15752768, isoform 1, isoform 3 and isoform 5 are both nuclear and cytoplasmic.
uniprot
proteins