CHST5
entrez
23563
canonical
uniprot
Q9GZS9
canonical
ensembl
ENSG00000135702
resolver
ensp
ENSP00000338783
resolver
genesymbol
CHST5
resolver
hgnc
HGNC:1973
resolver
uniprot
B2RV23
resolver
uniprot
Q7LCN3
resolver
uniprot
Q9UBY3
resolver
uniprot_entry
CHST5_HUMAN
resolver
uniprot_sec
B2RV23
resolver
uniprot_sec
Q7LCN3
resolver
uniprot_sec
Q9UBY3
resolver
amino_acid_sequence
MGMRARVPKVAHSTRRPPAARMWLPRFSSKTVTVLLLAQTTCLLLFIISRPGPSSPAGGEDRVHVLVLSSWRSGSSFLGQLFSQHPDVFYLMEPAWHVWTTLSQGSAATLHMAVRDLMRSIFLCDMDVFDAYMPQSRNLSAFFNWATSRALCSPPACSAFPRGTISKQDVCKTLCTRQPFSLAREACRSYSHVVLKEVRFFNLQVLYPLLSDPALNLRIVHLVRDPRAVLRSREAAGPILARDNGIVLGTNGKWVEADPHLRLIREVCRSHVRIAEAATLKPPPFLRGRYRLVRFEDLAREPLAEIRALYAFTGLTLTPQLEAWIHNITHGSGIGKPIEAFHTSSRNARNVSQAWRHALPFTKILRVQEVCAGALQLLGYRPVYSADQQRDLTLDLVLPRGPDHFSWASPD
uniprot
proteins
ec_number
2.8.2.-
uniprot
proteins
function
FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues and O-linked sugars of mucin-type acceptors (PubMed:10491328, PubMed:12218059, PubMed:12626414, PubMed:30093410). Acts on the non-reducing terminal GlcNAc of short carbohydrate substrates (in vitro) (PubMed:12218059). Preferentially add sulfate onto core 2- based O-glycan structures, but does not act on extended core 1 structures (in vitro) (PubMed:30093410). Involved in sulfation of endothelial mucins such as GLYCAM1 (PubMed:10491328, PubMed:12855678). Has no activity toward keratan (PubMed:11278593). Not involved in generating HEV-expressed ligands for SELL (PubMed:12855678). {ECO:0000269|PubMed:10491328, ECO:0000269|PubMed:11278593, ECO:0000269|PubMed:12218059, ECO:0000269|PubMed:12626414, ECO:0000269|PubMed:12855678, ECO:0000269|PubMed:30093410}.
uniprot
proteins
mass_dalton
46161
uniprot
proteins
protein_family
Gal/GlcNAc/GalNAc subfamily
uniprot
proteins
protein_family
Sulfotransferase 1 family
uniprot
proteins
pubmed
10491328
uniprot
proteins
pubmed
11017086
uniprot
proteins
pubmed
11278593
uniprot
proteins
pubmed
11352640
uniprot
proteins
pubmed
12107080
uniprot
proteins
pubmed
12218059
uniprot
proteins
pubmed
12626414
uniprot
proteins
pubmed
12855678
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
30093410
uniprot
proteins
sequence_length
411
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305|PubMed:12855678}; Single-pass type II membrane protein {ECO:0000305|PubMed:12855678}. Note=Golgi membrane, early secretory pathway. {ECO:0000269|PubMed:12855678}.
uniprot
proteins
transmembrane_region
TRANSMEM 31..48; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins