Mosmo
entrez
233812
canonical
uniprot
Q8C784
canonical
ensembl
ENSMUSG00000046096
resolver
ensp
ENSMUSP00000055934
resolver
ensp
ENSMUSP00000146331
resolver
ensp
ENSMUSP00000262173
resolver
enst
ENSMUST00000208454
resolver
genesymbol
Mosmo
resolver
genesymbol_syn
Atthog
resolver
genesymbol_syn
BC030336
resolver
uniprot
A0A140LH99
resolver
uniprot
Q3TS22
resolver
uniprot
Q8K0V1
resolver
uniprot_entry
A0A140LH99_MOUSE
resolver
uniprot_entry
MOSMO_MOUSE
resolver
uniprot_sec
Q3TS22
resolver
uniprot_sec
Q8K0V1
resolver
amino_acid_sequence
MDKLTIISGCLFLAADIFAIASIANPDWINTGESAGALTVGLVRQCQTIHGRDRTCIPPRLPPEWVTTLFFIIMGIISLTVTCGLLVASHWRREATKYARWIAFTGMILFCMAALIFPIGFYINEVGGQPYKLPNNTVVGSSYVLFVLSIFFTIVGLLFAGKVCLPG
uniprot
proteins
function
FUNCTION: Acts as a negative regulator of hedgehog signaling probably by promoting internalization and subsequent degradation of smoothened protein (SMO) present in the ciliary membrane (PubMed:29290584). Plays a role in sonic hedgehog (SHH)-induced spinal neural progenitor cells differentiation (PubMed:29290584). {ECO:0000269|PubMed:29290584}.
uniprot
proteins
mass_dalton
18250
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
29290584
uniprot
proteins
sequence_length
167
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000269|PubMed:29290584}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:29290584}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 68..88; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 101..121; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 139..159; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins