Tatdn3
entrez
68972
canonical
uniprot
Q3U1C6
canonical
ensembl
ENSMUSG00000026632
resolver
ensp
ENSMUSP00000027945
resolver
ensp
ENSMUSP00000082773
resolver
ensp
ENSMUSP00000106516
resolver
ensp
ENSMUSP00000106518
resolver
ensp
ENSMUSP00000314514
resolver
enst
ENSMUST00000027945
resolver
enst
ENSMUST00000110891
resolver
enst
ENSMUST00000110893
resolver
genesymbol
Tatdn3
resolver
uniprot
D3YXH9
resolver
uniprot
D3Z0V5
resolver
uniprot
E9QL22
resolver
uniprot
Q6P8H6
resolver
uniprot
Q9DB58
resolver
uniprot_entry
D3YXH9_MOUSE
resolver
uniprot_entry
D3Z0V5_MOUSE
resolver
uniprot_entry
E9QL22_MOUSE
resolver
uniprot_entry
TATD3_MOUSE
resolver
uniprot_sec
Q6P8H6
resolver
uniprot_sec
Q9DB58
resolver
activity_regulation
ACTIVITY REGULATION: The 3'-exonuclease activity is sensitive to the metal ion present in the active site, whereas the AP endodeoxyribonuclease activity is observed in a variety of divalent metal cofactors. 3'-exoxonuclease activity is suppressed in the presence of Ca(2+), Zn(2+) and Ni(2+). {ECO:0000250|UniProtKB:Q17R31}.
uniprot
proteins
amino_acid_sequence
MGLGLVDCHCHLSASDFDNDLDDVLEKARKANVMALVAVAEHAGEFERIMQLSERYNGFVLPCLGVHPVQELSPEKPRSVTLKDLDVALPIIEKYKDRLLAIGEVGLDFTPRYAGTDEEKEEQRQVLIRQVQLAKRLNVPLNVHSRSAGRPTISLLREQGAEQVLLHAFDGRPSVAMEGVRAGYYFSIPPSIVRSGQKQKLVKQLPLSSICLETDSPALGPEKLTRNEPCNISIAAEFIAQVKGISVEEVREVTTRNAFRLFPKLQSLLQKELQSHPLQAKSAQGSAGESKGLL
uniprot
proteins
ec_number
3.1.21.-
uniprot
proteins
function
FUNCTION: Exhibits 3'-exonuclease and apurinic/apyrimidinic (AP) endonuclease activities (in vitro). Show preferential AP endonuclease activity on double-stranded DNA substrates and 3'- exonuclease activity on single-stranded DNA. {ECO:0000250|UniProtKB:Q17R31}.
uniprot
proteins
mass_dalton
32436
uniprot
proteins
protein_family
Metallo-dependent hydrolases superfamily
uniprot
proteins
protein_family
TatD-type hydrolase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
294
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins