Dcxr
entrez
67880
canonical
uniprot
Q91X52
canonical
ensembl
ENSMUSG00000039450
resolver
ensp
ENSMUSP00000026144
resolver
ensp
ENSMUSP00000101754
resolver
enst
ENSMUST00000026144
resolver
enst
ENSMUST00000106148
resolver
genesymbol
Dcxr
resolver
uniprot
A2AC16
resolver
uniprot
Q3U5L5
resolver
uniprot
Q9D129
resolver
uniprot
Q9D8W1
resolver
uniprot_entry
A2AC16_MOUSE
resolver
uniprot_entry
DCXR_MOUSE
resolver
uniprot_sec
Q3U5L5
resolver
uniprot_sec
Q9D129
resolver
uniprot_sec
Q9D8W1
resolver
activity_regulation
ACTIVITY REGULATION: Competitively inhibited by butanoic acid, which binds to the enzyme-NADP(+) complex (PubMed:11882650). Inhibited by 4-methyl-[1,2,3]-thiadiazole-5-carboxylic acid benzyloxyamide (MTB) and 4-methylthiophene-2-carboxylic acid N-(2,3,3-trichloroacryloyl)-hydrazide (MTT) (PubMed:15906319). {ECO:0000269|PubMed:11882650, ECO:0000269|PubMed:15906319}.
uniprot
proteins
amino_acid_sequence
MDLGLAGRRALVTGAGKGIGRSTVLALKAAGAQVVAVSRTREDLDDLVRECPGVEPVCVDLADWEATEQALSNVGPVDLLVNNAAVALLQPFLEVTKEACDTSFNVNLRAVIQVSQIVAKGMIARGVPGAIVNVSSQASQRALTNHTVYCSTKGALDMLTKMMALELGPHKIRVNAVNPTVVMTPMGRTNWSDPHKAKAMLDRIPLGKFAEVENVVDTILFLLSNRSGMTTGSTLPVDGGFLAT
uniprot
proteins
ec_number
1.1.1.10
uniprot
proteins
function
FUNCTION: Catalyzes the NADPH-dependent reduction of several pentoses, tetroses, trioses, alpha-dicarbonyl compounds and L-xylulose (PubMed:11882650). Can use both NAD and NADP as cosubstrate but shows higher activity with NADP (PubMed:11882650). Participates in the uronate cycle of glucose metabolism (PubMed:11882650). May play a role in the water absorption and cellular osmoregulation in the proximal renal tubules by producing xylitol, an osmolyte, thereby preventing osmolytic stress from occurring in the renal tubules (PubMed:11882650). {ECO:0000269|PubMed:11882650, ECO:0000303|PubMed:11882650}.
uniprot
proteins
mass_dalton
25746
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
11882650
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15906319
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
244
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:11882650}; Peripheral membrane protein {ECO:0000269|PubMed:11882650}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q91XV4}. Note=Probably recruited to membranes via an interaction with phosphatidylinositol (By similarity). In kidney, it is localized in the brush border membranes of proximal tubular cells (PubMed:11882650). {ECO:0000250|UniProtKB:Q91XV4, ECO:0000269|PubMed:11882650}.
uniprot
proteins