Susd4
entrez
96935
canonical
uniprot
Q8BH32
canonical
ensembl
ENSMUSG00000038576
resolver
ensp
ENSMUSP00000082873
resolver
ensp
ENSMUSP00000119488
resolver
ensp
ENSMUSP00000321838
resolver
ensp
ENSMUSP00000321853
resolver
genesymbol
Susd4
resolver
uniprot
Q8VC43
resolver
uniprot_entry
SUSD4_MOUSE
resolver
uniprot_sec
Q8VC43
resolver
amino_acid_sequence
MYHGMNPSNGDGFLEQQLQQQQPQSPQRLLAVILWFQLALCFGPAQLTGGFDDLNVCADPGVPENGFRTPSGGVFFESSVTRFHCQDGFRLKGSTKRLCMKHFNGTLGWVPSDKPVCIQEDCRIPQIEDAEIRNKTYRHGEKLVIDCHEGFKIRYPDLYNLVSLCRDDGTWDNLPICQGCLRPLASSNGYVNISEFQTSFPVGTVIAYRCFPGFKLEGSENLECLHNLIWSSSPPRCLALEVCPLPPMVSHGDFICHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEWFPSYQVYCIKSEQTWPSTHETLLTTWKIVAFTATSVLLVLLLVILARMFQTKFKAHFPPRGPPRSSSSDPDFVVVDGVPVMLPTYDEAVNGSSSALGPGYPASVGQGCPLPVDDQSPPAYPGSGDTDTGPGESETCDSTSGSSEMLQSLYSPPMCQGGSRPAPDTPDTISSTAGEVASTSPGIDIADEIPLMEEDP
uniprot
proteins
function
FUNCTION: Acts as a complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways. {ECO:0000250|UniProtKB:Q5VX71, ECO:0000269|PubMed:20348246}.
uniprot
proteins
mass_dalton
53797
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20348246
uniprot
proteins
sequence_length
490
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 320..340; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins