RAB41
entrez
347517
canonical
uniprot
Q5JT25
canonical
ensembl
ENSG00000147127
resolver
ensp
ENSP00000276066
resolver
ensp
ENSP00000363597
resolver
genesymbol
RAB41
resolver
hgnc
HGNC:18293
resolver
uniprot
Q17RQ0
resolver
uniprot_entry
RAB41_HUMAN
resolver
uniprot_sec
Q17RQ0
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000250|UniProtKB:P20340}.
uniprot
proteins
amino_acid_sequence
MSAFGHDEAWMEAGGFGLEAAERTEYQSLCKSKLLFLGEQSVGKTSIISRFMYNSFGCACQATVGIDFLSKTMYLEDQIVQLQLWDTAGQERFHSLIPSYIRDSTIAVVVYDITNINSFKETDKWVEHVRAERGDDVVIMLLGNKIDLDNKRQVTAEQGEEKSRNLNVMFIETSAKTGYNVKKLFRRVASALLSTRTSPPPKEGTVEIELESFEESGNRSYC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:23936529). RAB41 is required for normal Golgi ribbon organization and ER-to-Golgi trafficking (PubMed:23936529). {ECO:0000269|PubMed:23936529}.
uniprot
proteins
mass_dalton
25038
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15018353
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
23936529
uniprot
proteins
sequence_length
222
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23936529}. Note=punctate localization concentrated in ruffled regions at the cell periphery.
uniprot
proteins