Sox30
entrez
214105
canonical
uniprot
Q8CGW4
canonical
ensembl
ENSMUSG00000040489
resolver
ensp
ENSMUSP00000037519
resolver
enst
ENSMUST00000049038
resolver
genesymbol
Sox30
resolver
uniprot_entry
SOX30_MOUSE
resolver
amino_acid_sequence
MERARPEPPPPPPPPPRQPPRPTPPRPLRPAPPAQPVEAATFRAAAAERSQSPSAQATAAMAAVASSCGEAAAAGAQAAGTRRLLQVKPEQVLLLPPGGPGVPPAPDEGAAAAAAAAAAAASSAQARLLQLRPELLLLPPQSAADGGPCRPELHPMQPRTLLVKAEKQELGAGLDLSVGSRRTTEAGPRASRAAKLDGTGKALDGRRSDEKKAKLEAEEAPRDALKGGEGKSLLAIGEGVIKTEEPDRPRDDCRLGTEATSNGLVHSSKEAILAQPPSAFGPHQQDLRFPLTLHTVPPGARIQFQGPPPSELIRLSKVPLTPVPIKMQSLLEPSVKIETKDVPLTVLPSDAGIPDTPFSKDRNGHVKRPMNAFMVWARIHRPALAKANPAANNAEISVQLGLEWNKLSEEQKKPYYDEAQKIKEKHREEFPGWVYQPRPGKRKRFPLSVSNVFSGTTQNIISTNPTTIYPYRSPTYSVVIPGLQNTITHPVGEAPPAIQLPTPAVQRPSPITLFQPSVSSTGPVAVPPPSLTPRPSLPPQRFSGPSQTDIHRLPSGSSRSVKRSTPGSLESTTRIPAGASTAHARFATSPIQPPKEYASVSTCPRSTPIPPATPIPHSHVYQPPPLGHPATLFGTPPRFSFHHPYFLPGPHYFPSSTCPYSRPPFGYGNFPSSMPECLGYYEDRYQKHEAIFSALNRDYPFRDYPDEHTHSEDSRSCESMDGPPYYSSHGHGGEEYLNAMPTLDIGALENVFTAPASAPSGVQQVNVTDSDEEEEEKVLRNL
uniprot
proteins
function
FUNCTION: Acts both as a transcriptional activator and a repressor (PubMed:29848638, PubMed:29866902). Binds to the DNA sequence 5'-ACAAT-3' and shows a preference for guanine residues surrounding this core motif (PubMed:29866902). Binds to its own promoter and activates its own transcription (PubMed:29848638, PubMed:29866902). Required to activate the expression of postmeiotic genes involved in spermiogenesis (PubMed:29848638, PubMed:29866902). Binds to the promoter region of CTNNB1 and represses its transcription which leads to inhibition of Wnt signaling (PubMed:29739711). Also inhibits Wnt signaling by binding to the CTNNB1 protein, preventing interaction of CTNNB1 with TCF7L2/TCF4 (By similarity). {ECO:0000250|UniProtKB:O94993, ECO:0000269|PubMed:29739711, ECO:0000269|PubMed:29848638, ECO:0000269|PubMed:29866902}.
uniprot
proteins
mass_dalton
83938
uniprot
proteins
pubmed
10359848
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25609838
uniprot
proteins
pubmed
29739711
uniprot
proteins
pubmed
29848638
uniprot
proteins
pubmed
29866902
uniprot
proteins
pubmed
31113793
uniprot
proteins
sequence_length
782
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25609838, ECO:0000269|PubMed:29848638, ECO:0000269|PubMed:29866902}. Cytoplasm {ECO:0000250|UniProtKB:O94993}. Note=Enriched at the chromocenter. {ECO:0000269|PubMed:29848638}.
uniprot
proteins