Tspan1
entrez
66805
canonical
uniprot
Q99J59
canonical
ensembl
ENSMUSG00000028699
resolver
ensp
ENSMUSP00000030465
resolver
ensp
ENSMUSP00000121906
resolver
enst
ENSMUST00000030465
resolver
genesymbol
Tspan1
resolver
uniprot
A6PW93
resolver
uniprot_entry
TSN1_MOUSE
resolver
uniprot_sec
A6PW93
resolver
amino_acid_sequence
MQCFKFIKVMMFLFNLLIFLCGAALLAVGIWVSVDGTSFLKVFGSLSSSAMQFVNVGYFLIAAGAVLFILGFLGCYGAHSENKCVLMMFFSILLIIFIAEIAGAVVALVYTTLAEQFLTLLVVPAIEKDYGYQTDFTQVWNTTMEELHCCGFNNYTDFNASRFVKENKVFPPPCCANPGNHTVEPCTEEKAKSMKVQGCFKEILHRIRANAVTVGGVAVGVAALELAAMVVSMYLYCNLK
uniprot
proteins
function
FUNCTION: Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking (By similarity). Regulates neuronal differentiation in response to NGF by facilitating NGF-mediated activation of NTRK1/TRKA receptor tyrosine kinase and subsequent downstream signaling pathways (By similarity). Plays a role in the inhibition of TNFalpha-induced apoptosis. Mechanistically, inhibits the NF-kappa-B signaling pathway by blocking phosphorylation of CHUK. Also promotes the stability of the thiamine transporter 1/SLC19A2 in intestinal epithelial cells leading to an increase of thiamine uptake process (By similarity). {ECO:0000250|UniProtKB:O60635, ECO:0000250|UniProtKB:Q6AYR9}.
uniprot
proteins
mass_dalton
26356
uniprot
proteins
protein_family
Tetraspanin (TM4SF) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
240
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 53..73; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 89..109; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 211..231; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins