Musk
entrez
81725
canonical
uniprot
Q62838
canonical
ensembl
ENSRNOG00000033567
resolver
ensp
ENSRNOP00000093853
resolver
enst
ENSRNOT00000118034
resolver
genesymbol
Musk
resolver
uniprot
A0A8I6AL77
resolver
uniprot_entry
A0A8I6AL77_RAT
resolver
uniprot_entry
MUSK_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Positively regulated by CK2. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MRELVNIPLLQMLTLVAFSGTEKLPKAPVITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCTANNGVGGAVESCGALQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSALRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKLVKLEVEVFARILRAPESHNVTFGSFVTLRCTAIGMPVPTISWIENGNAVSSGSIQENVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTAKAAATVSIAEWSKSQKESKGYCAQYRGEVCDAVLVKDSLVFFNTSYPDPEEAQELLIHTAWNELKAVSPLCRPAAEALLCNHLFQECSPGVLPTPMPICREYCLAVKELFCAKEWLAMEGKTHRGLYRSGMHFLPVPECSKLPSMHQDPTACTRLPYLDYKKENITTFPSITSSKPSVDIPNLPASTSSFAVSPAYSMTVIISIMSCFAVFALLTITTLYCCRRRREWKNKKRESAAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIADFGLSRNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSIHRILQRMCERAEGTVGV
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:23326516). Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role in acetylcholinesterase (AChE) localization at the neuromuscular junctions (NMJ) via its interaction wit COLQ (PubMed:15159418). May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation. {ECO:0000269|PubMed:15159418, ECO:0000269|PubMed:16870737, ECO:0000269|PubMed:17011580, ECO:0000269|PubMed:23326516}.
uniprot
proteins
mass_dalton
96822
uniprot
proteins
mutagenesis
MUTAGEN 48; /note="M->R: Strongly reduced agrin-dependent activation and autophosphorylation."; /evidence="ECO:0000269|PubMed:17011580"; MUTAGEN 83; /note="L->R: Abolishes agrin-dependent activation and autophosphorylation."; /evidence="ECO:0000269|PubMed:17011580"; MUTAGEN 96; /note="I->A: Abolishes agrin-dependent activation and autophosphorylation."; /evidence="ECO:0000269|PubMed:17011580"; MUTAGEN 789; /note="V->M: Reduces interaction with DOK7."; /evidence="ECO:0000269|PubMed:23326516"; MUTAGEN 834; /note="M->V: Reduces LRP4- and AGRIN-dependent phosphorylation. Reduces DOK7-dependent phosphorylation. Reduces agrin-dependent AChR aggregation in neuromuscular junction. Reduces interaction with DOK7."; /evidence="ECO:0000269|PubMed:23326516
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by PDZRN3. Ubiquitination promotes endocytosis and lysosomal degradation (By similarity). {ECO:0000250}.; PTM: Phosphorylated (PubMed:23326516). Phosphorylation is induced by AGRIN in a LRP4-dependent manner (PubMed:23326516). Autophosphorylated (By similarity). Autophosphorylation at Tyr-553 is required for interaction with DOK7 which in turn stimulates the phosphorylation and the activation of MUSK (By similarity). {ECO:0000250|UniProtKB:Q61006, ECO:0000269|PubMed:23326516}.; PTM: Neddylated. {ECO:0000250}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
12220490
uniprot
proteins
pubmed
15159418
uniprot
proteins
pubmed
16870737
uniprot
proteins
pubmed
17011580
uniprot
proteins
pubmed
18848351
uniprot
proteins
pubmed
19038220
uniprot
proteins
pubmed
19664639
uniprot
proteins
pubmed
20603078
uniprot
proteins
pubmed
23326516
uniprot
proteins
pubmed
7546737
uniprot
proteins
sequence_length
868
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000305|PubMed:17011580}; Single-pass type I membrane protein {ECO:0000305|PubMed:17011580}. Note=Localizes to the postsynaptic cell membrane of the neuromuscular junction. {ECO:0000250|UniProtKB:O15146, ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 495..515; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins