CETP
entrez
1071
canonical
uniprot
P11597
canonical
ensembl
ENSG00000087237
resolver
ensp
ENSP00000200676
resolver
ensp
ENSP00000369106
resolver
ensp
ENSP00000787323
resolver
genesymbol
CETP
resolver
hgnc
HGNC:1869
resolver
uniprot
A0A0S2Z3F6
resolver
uniprot
A0A0S2Z3I8
resolver
uniprot
B4DMZ5
resolver
uniprot
Q13987
resolver
uniprot
Q13988
resolver
uniprot
Q53YZ1
resolver
uniprot_entry
A0A0S2Z3F6_HUMAN
resolver
uniprot_entry
A0A0S2Z3I8_HUMAN
resolver
uniprot_entry
B4DMZ5_HUMAN
resolver
uniprot_entry
CETP_HUMAN
resolver
uniprot_sec
Q13987
resolver
uniprot_sec
Q13988
resolver
uniprot_sec
Q53YZ1
resolver
amino_acid_sequence
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS
uniprot
proteins
disease_involvement
DISEASE: Hyperalphalipoproteinemia 1 (HALP1) [MIM:143470]: A condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels. {ECO:0000269|PubMed:12091484, ECO:0000269|PubMed:2215607, ECO:0000269|PubMed:8408659}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed:24293641, PubMed:3281933, PubMed:3600759). Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (PubMed:17237796). {ECO:0000269|PubMed:24293641, ECO:0000269|PubMed:3281933, ECO:0000303|PubMed:17237796, ECO:0000305|PubMed:3600759}.
uniprot
proteins
mass_dalton
54756
uniprot
proteins
mutagenesis
MUTAGEN 155; /note="T->Y: Reduces triglyceride transfer and cholesteryl ester transfer 5-fold."; /evidence="ECO:0000269|PubMed:17237796"; MUTAGEN 215; /note="V->W: Reduces triglyceride transfer 10-fold. No effect on cholesteryl ester transfer."; /evidence="ECO:0000269|PubMed:17237796"; MUTAGEN 218; /note="R->S: Reduces triglyceride transfer 10-fold. Slight reduction of cholesteryl ester transfer."; /evidence="ECO:0000269|PubMed:17237796"; MUTAGEN 247; /note="S->A: Reduces triglyceride transfer 5-fold. Slight reduction of cholesteryl ester transfer."; /evidence="ECO:0000269|PubMed:17237796"; MUTAGEN 282; /note="F->R: Not secreted."; /evidence="ECO:0000269|PubMed:17237796"; MUTAGEN 287; /note="F->R: Not secreted."; /evidence="ECO:0000269|PubMed:17237796"; MUTAGEN 309; /note="F->D: Not secreted."; /evidence="ECO:0000269|PubMed:17237796"; MUTAGEN 313; /note="L->Q: Reduces cholesteryl ester transfer by 60%."; /evidence="ECO:0000269|PubMed:17237796"; MUTAGEN 392; /note="Y->S: Not secreted."; /evidence="ECO:0000269|PubMed:17237796"; MUTAGEN 399; /note="L->W: Not secreted."; /evidence="ECO:0000269|PubMed:17237796"; MUTAGEN 433; /note="V->R: Reduces activity by 60%."; /evidence="ECO:0000269|PubMed:17237796
uniprot
proteins
protein_family
BPI/LBP family
uniprot
proteins
protein_family
BPI/LBP/Plunc superfamily
uniprot
proteins
pubmed
10391209
uniprot
proteins
pubmed
12091484
uniprot
proteins
pubmed
12966036
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
17237796
uniprot
proteins
pubmed
17952847
uniprot
proteins
pubmed
19139490
uniprot
proteins
pubmed
2215607
uniprot
proteins
pubmed
2334701
uniprot
proteins
pubmed
24293641
uniprot
proteins
pubmed
3281933
uniprot
proteins
pubmed
3600759
uniprot
proteins
pubmed
8408659
uniprot
proteins
pubmed
8943225
uniprot
proteins
pubmed
9332354
uniprot
proteins
sequence_length
493
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24293641, ECO:0000269|PubMed:3281933}. Note=Secreted in plasma. {ECO:0000269|PubMed:3281933}.
uniprot
proteins