Duoxa1
entrez
213696
canonical
uniprot
Q8VE49
canonical
ensembl
ENSMUSG00000027224
resolver
ensp
ENSMUSP00000028653
resolver
ensp
ENSMUSP00000106166
resolver
enst
ENSMUST00000028653
resolver
enst
ENSMUST00000110537
resolver
genesymbol
Duoxa1
resolver
uniprot
A2AQ97
resolver
uniprot_entry
DOXA1_MOUSE
resolver
uniprot_sec
A2AQ97
resolver
amino_acid_sequence
MAALGHTLPFYTGTKPTFPMDTTLAVIITIFLTALVTFIIILPGIRGKTRLFWLLRVVTSLFIGAVILAVNFSSEWSVGHVNANTTYKAFSPKWVSVDVGLQIGLGGVNITLTGTPVQQLNETINYNEAFAWRLGRSYAEEYAKALEKGLPDPVLYLAEKFTPRSPCGLYNQYRLAGHYASAMLWVAFLCWLLANVMLSMPVLVYGGHMLLATGLFQLLALFFFSMTTSLISPCPLRLGTAVLHTHHGPAFWITLATGLLCILLGLVMAVAHRMQPHRLKAFFNQSSEDPVLEWGSEEGGLLSPHYRSIAESPETQDIPMSVASSETCFKEEHPKESDCSL
uniprot
proteins
function
FUNCTION: Required for the maturation and transport of functional DUOX1 from the endoplasmic reticulum to the plasma membrane. Recruits DUOX1 to the apical cell membrane. {ECO:0000250|UniProtKB:Q1HG43}.
uniprot
proteins
mass_dalton
37588
uniprot
proteins
post_translational_modification
PTM: N-glycosylation of DUOXA1 is required for sorting of DUOX1 to the apical cell membrane. {ECO:0000250|UniProtKB:Q1HG43}.
uniprot
proteins
protein_family
DUOXA family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
32929281
uniprot
proteins
sequence_length
341
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q1HG43}; Multi-pass membrane protein {ECO:0000269|PubMed:32929281}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..43; /note="Helical"; /evidence="ECO:0000269|PubMed:32929281, ECO:0007744|PDB:6WXU"; TRANSMEM 51..72; /note="Helical"; /evidence="ECO:0000269|PubMed:32929281, ECO:0007744|PDB:6WXU"; TRANSMEM 175..199; /note="Helical"; /evidence="ECO:0000269|PubMed:32929281, ECO:0007744|PDB:6WXU"; TRANSMEM 204..226; /note="Helical"; /evidence="ECO:0000269|PubMed:32929281, ECO:0007744|PDB:6WXU"; TRANSMEM 249..270; /note="Helical"; /evidence="ECO:0000269|PubMed:32929281, ECO:0007744|PDB:6WXU
uniprot
proteins