DOK1
entrez
1796
canonical
uniprot
Q99704
canonical
ensembl
ENSG00000115325
resolver
ensp
ENSP00000233668
resolver
ensp
ENSP00000344330
resolver
ensp
ENSP00000387016
resolver
genesymbol
DOK1
resolver
hgnc
HGNC:2990
resolver
uniprot
B3KP83
resolver
uniprot
B4DJN1
resolver
uniprot
O43204
resolver
uniprot
Q14CB2
resolver
uniprot
Q2TA81
resolver
uniprot
Q53TY2
resolver
uniprot
Q9UHG6
resolver
uniprot_entry
B3KP83_HUMAN
resolver
uniprot_entry
B4DJN1_HUMAN
resolver
uniprot_entry
DOK1_HUMAN
resolver
uniprot_entry
Q14CB2_HUMAN
resolver
uniprot_entry
Q2TA81_HUMAN
resolver
uniprot_sec
O43204
resolver
uniprot_sec
Q53TY2
resolver
uniprot_sec
Q9UHG6
resolver
amino_acid_sequence
MDGAVMEGPLFLQSQRFGTKRWRKTWAVLYPASPHGVARLEFFDHKGSSSGGGRGSSRRLDCKVIRLAECVSVAPVTVETPPEPGATAFRLDTAQRSHLLAADAPSSAAWVQTLCRNAFPKGSWTLAPTDNPPKLSALEMLENSLYSPTWEGSQFWVTVQRTEAAERCGLHGSYVLRVEAERLTLLTVGAQSQILEPLLSWPYTLLRRYGRDKVMFSFEAGRRCPSGPGTFTFQTAQGNDIFQAVETAIHRQKAQGKAGQGHDVLRADSHEGEVAEGKLPSPPGPQELLDSPPALYAEPLDSLRIAPCPSQDSLYSDPLDSTSAQAGEGVQRKKPLYWDLYEHAQQQLLKAKLTDPKEDPIYDEPEGLAPVPPQGLYDLPREPKDAWWCQARVKEEGYELPYNPATDDYAVPPPRSTKPLLAPKPQGPAFPEPGTATGSGIKSHNSALYSQVQKSGASGSWDCGLSRVGTDKTGVKSEGST
uniprot
proteins
function
FUNCTION: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK1 appears to be a negative regulator of the insulin signaling pathway. Modulates integrin activation by competing with talin for the same binding site on ITGB3. {ECO:0000269|PubMed:18156175}.
uniprot
proteins
mass_dalton
52392
uniprot
proteins
mutagenesis
MUTAGEN 362; /note="Y->F: No association with NCK. No association with GAP; when associated with F-398."; /evidence="ECO:0000269|PubMed:11551902"; MUTAGEN 398; /note="Y->F: No association with GAP; when associated with F-362."; /evidence="ECO:0000269|PubMed:11551902
uniprot
proteins
post_translational_modification
PTM: Constitutively tyrosine-phosphorylated. Phosphorylated by TEC (By similarity). Phosphorylated by LYN (By similarity). Phosphorylated on tyrosine residues by the insulin receptor kinase. Results in the negative regulation of the insulin signaling pathway. Phosphorylated on tyrosine residues by SRMS. {ECO:0000250, ECO:0000269|PubMed:11551902, ECO:0000269|PubMed:23822091, ECO:0000269|PubMed:9008160}.
uniprot
proteins
protein_family
DOK family
uniprot
proteins
protein_family
Type A subfamily
uniprot
proteins
pubmed
10940083
uniprot
proteins
pubmed
11551902
uniprot
proteins
pubmed
12595900
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18156175
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19481542
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23822091
uniprot
proteins
pubmed
9008160
uniprot
proteins
sequence_length
481
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm, perinuclear region.
uniprot
proteins