APOA5
entrez
116519
canonical
uniprot
Q6Q788
canonical
ensembl
ENSG00000110243
resolver
ensp
ENSP00000227665
resolver
ensp
ENSP00000399701
resolver
ensp
ENSP00000445002
resolver
ensp
ENSP00000543080
resolver
ensp
ENSP00000543081
resolver
ensp
ENSP00000543082
resolver
ensp
ENSP00000543083
resolver
ensp
ENSP00000543084
resolver
ensp
ENSP00000543085
resolver
enst
ENST00000227665
resolver
enst
ENST00000433069
resolver
enst
ENST00000542499
resolver
enst
ENST00000873021
resolver
enst
ENST00000873022
resolver
enst
ENST00000873023
resolver
enst
ENST00000873024
resolver
enst
ENST00000873025
resolver
enst
ENST00000873026
resolver
genesymbol
APOA5
resolver
genesymbol_syn
RAP3
resolver
hgnc
HGNC:17288
resolver
uniprot
B0YIV9
resolver
uniprot
Q3MIK6
resolver
uniprot
Q6UWK9
resolver
uniprot
Q9UBJ3
resolver
uniprot_entry
APOA5_HUMAN
resolver
uniprot_sec
B0YIV9
resolver
uniprot_sec
Q3MIK6
resolver
uniprot_sec
Q6UWK9
resolver
uniprot_sec
Q9UBJ3
resolver
amino_acid_sequence
MASMAAVLTWALALLSAFSATQARKGFWDYFSQTSGDKGRVEQIHQQKMAREPATLKDSLEQDLNNMNKFLEKLRPLSGSEAPRLPQDPVGMRRQLQEELEEVKARLQPYMAEAHELVGWNLEGLRQQLKPYTMDLMEQVALRVQELQEQLRVVGEDTKAQLLGGVDEAWALLQGLQSRVVHHTGRFKELFHPYAESLVSGIGRHVQELHRSVAPHAPASPARLSRCVQVLSRKLTLKAKALHARIQQNLDQLREELSRAFAGTGTEEGAGPDPQMLSEEVRQRLQAFRQDTYLQIAAFTRAIDQETEEVQQQLAPPPPGHSAFAPEFQQTDSGKVLSKLQARLDDLWEDITHSLHDQGHSHLGDP
uniprot
proteins
disease_involvement
DISEASE: Hypertriglyceridemia 1 (HYTG1) [MIM:145750]: A common inherited disorder in which the concentration of very low density lipoprotein (VLDL) is elevated in the plasma. This leads to increased risk of heart disease, obesity, and pancreatitis. Inheritance is autosomal dominant. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; DISEASE: Hyperlipoproteinemia 5 (HLPP5) [MIM:144650]: Characterized by increased amounts of chylomicrons and very low density lipoprotein (VLDL) and decreased low density lipoprotein (LDL) and high density lipoprotein (HDL) in the plasma after a fast. Numerous conditions cause this phenotype, including insulin-dependent diabetes mellitus, contraceptive steroids, alcohol abuse, and glycogen storage disease type 1A (GSD1A). {ECO:0000269|PubMed:16200213}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and an inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate) (By similarity). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Binds heparin (PubMed:17326667). {ECO:0000250|UniProtKB:Q8C7G5, ECO:0000269|PubMed:11588264, ECO:0000269|PubMed:12899628, ECO:0000269|PubMed:15528295, ECO:0000269|PubMed:17326667}.
uniprot
proteins
mass_dalton
41213
uniprot
proteins
mutagenesis
MUTAGEN 233..234; /note="RK->EQ: Decreased heparin-binding."; /evidence="ECO:0000269|PubMed:17326667
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by FAM20C in the extracellular medium. {ECO:0000269|PubMed:26091039}.
uniprot
proteins
protein_family
Apolipoprotein A1/A4/E family
uniprot
proteins
pubmed
11577099
uniprot
proteins
pubmed
11588264
uniprot
proteins
pubmed
12417524
uniprot
proteins
pubmed
12709436
uniprot
proteins
pubmed
12810715
uniprot
proteins
pubmed
12899628
uniprot
proteins
pubmed
12915450
uniprot
proteins
pubmed
12920097
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15108119
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15528295
uniprot
proteins
pubmed
16200213
uniprot
proteins
pubmed
17326667
uniprot
proteins
pubmed
17997385
uniprot
proteins
pubmed
18603531
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26091039
uniprot
proteins
sequence_length
366
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12810715}. Early endosome {ECO:0000269|PubMed:18603531}. Late endosome {ECO:0000269|PubMed:18603531}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:18603531}. Note=In the presence of SORL1, internalized to early endosomes, sorted in a retrograde fashion to late endosomes, from which a portion is sent to lysosomes and degradation, another portion is sorted to the trans-Golgi network. {ECO:0000269|PubMed:18603531}.
uniprot
proteins