Grn
entrez
14824
canonical
uniprot
P28798
canonical
ensembl
ENSMUSG00000034708
resolver
ensp
ENSMUSP00000046340
resolver
ensp
ENSMUSP00000159379
resolver
enst
ENSMUST00000049460
resolver
enst
ENSMUST00000239431
resolver
genesymbol
Grn
resolver
uniprot
F8WIJ1
resolver
uniprot
Q3U9N4
resolver
uniprot
Q544Y8
resolver
uniprot
Q9D2V3
resolver
uniprot_entry
F8WIJ1_MOUSE
resolver
uniprot_entry
GRN_MOUSE
resolver
uniprot_entry
Q3U9N4_MOUSE
resolver
uniprot_entry
Q544Y8_MOUSE
resolver
uniprot_entry
Q9D2V3_MOUSE
resolver
amino_acid_sequence
MWVLMSWLAFAAGLVAGTQCPDGQFCPVACCLDQGGANYSCCNPLLDTWPRITSHHLDGSCQTHGHCPAGYSCLLTVSGTSSCCPFSKGVSCGDGYHCCPQGFHCSADGKSCFQMSDNPLGAVQCPGSQFECPDSATCCIMVDGSWGCCPMPQASCCEDRVHCCPHGASCDLVHTRCVSPTGTHTLLKKFPAQKTNRAVSLPFSVVCPDAKTQCPDDSTCCELPTGKYGCCPMPNAICCSDHLHCCPQDTVCDLIQSKCLSKNYTTDLLTKLPGYPVKEVKCDMEVSCPEGYTCCRLNTGAWGCCPFAKAVCCEDHIHCCPAGFQCHTEKGTCEMGILQVPWMKKVIAPLRLPDPQILKSDTPCDDFTRCPTNNTCCKLNSGDWGCCPIPEAVCCSDNQHCCPQGFTCLAQGYCQKGDTMVAGLEKIPARQTTPLQIGDIGCDQHTSCPVGQTCCPSLKGSWACCQLPHAVCCEDRQHCCPAGYTCNVKARTCEKDVDFIQPPVLLTLGPKVGNVECGEGHFCHDNQTCCKDSAGVWACCPYLKGVCCRDGRHCCPGGFHCSARGTKCLRKKIPRWDMFLRDPVPRPLL
uniprot
proteins
function
FUNCTION: Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation (PubMed:12524533, PubMed:20026663, PubMed:23041626, PubMed:27789271, PubMed:28073925, PubMed:28453791, PubMed:28541286, PubMed:8496151). Regulates protein trafficking to lysosomes, and also the activity of lysosomal enzymes (PubMed:27789271, PubMed:28453791, PubMed:28541286). Also facilitates the acidification of lysosomes, causing degradation of mature CTSD by CTSB (PubMed:28073925). In addition, functions as a wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures (PubMed:12524533). Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases (PubMed:8496151). Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity (PubMed:20026663, PubMed:23041626). {ECO:0000269|PubMed:12524533, ECO:0000269|PubMed:20026663, ECO:0000269|PubMed:23041626, ECO:0000269|PubMed:27789271, ECO:0000269|PubMed:28073925, ECO:0000269|PubMed:28453791, ECO:0000269|PubMed:28541286, ECO:0000269|PubMed:8496151}.; FUNCTION: [Granulin-3]: Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8. {ECO:0000250|UniProtKB:P28799}.; FUNCTION: [Granulin-7]: Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity. {ECO:0000250|UniProtKB:P28799}.
uniprot
proteins
mass_dalton
63458
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:8496151}.; PTM: Cleaved by ELANE; proteolysis is blocked by SLPI and is concentration- and time-dependent and induces CXCL8/IL-8 production; granulin-3 and granulin-4 are resistant to ELANE (By similarity). Cleaved by CTSL in lysosome thus regulating the maturation and turnover of progranulin within the lysosome (PubMed:28835281). {ECO:0000250|UniProtKB:P28799, ECO:0000269|PubMed:28835281}.
uniprot
proteins
protein_family
Granulin family
uniprot
proteins
pubmed
12524533
uniprot
proteins
pubmed
12526812
uniprot
proteins
pubmed
1618805
uniprot
proteins
pubmed
20026663
uniprot
proteins
pubmed
21092856
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23041626
uniprot
proteins
pubmed
26370502
uniprot
proteins
pubmed
27789271
uniprot
proteins
pubmed
28073925
uniprot
proteins
pubmed
28453791
uniprot
proteins
pubmed
28541286
uniprot
proteins
pubmed
28728022
uniprot
proteins
pubmed
28835281
uniprot
proteins
pubmed
32761777
uniprot
proteins
pubmed
32852886
uniprot
proteins
pubmed
32929860
uniprot
proteins
pubmed
8471244
uniprot
proteins
pubmed
8482392
uniprot
proteins
pubmed
8496151
uniprot
proteins
sequence_length
589
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:28073925, ECO:0000269|PubMed:28541286, ECO:0000269|PubMed:8496151}. Lysosome {ECO:0000269|PubMed:27789271, ECO:0000269|PubMed:28073925}. Note=Endocytosed by SORT1 and delivred to lysosomes. Targeted to lysosome by PSAP via M6PR and LRP1, in both biosynthetic and endocytic pathways (By similarity). Co-localized with GBA1 in the intracellular trafficking compartments until to lysosome (PubMed:27789271). {ECO:0000250|UniProtKB:P28799, ECO:0000269|PubMed:27789271}.
uniprot
proteins