Aox3
entrez
71724
canonical
uniprot
G3X982
canonical
ensembl
ENSMUSG00000064294
resolver
ensp
ENSMUSP00000049391
resolver
ensp
ENSMUSP00000326478
resolver
enst
ENSMUST00000040999
resolver
genesymbol
Aox3
resolver
genesymbol_syn
Aoh1
resolver
uniprot
B2RSI5
resolver
uniprot
Q8C6Q4
resolver
uniprot
Q8VI15
resolver
uniprot
Q9CW59
resolver
uniprot_entry
AOXC_MOUSE
resolver
uniprot_entry
Q8C6Q4_MOUSE
resolver
uniprot_entry
Q9CW59_MOUSE
resolver
uniprot_sec
B2RSI5
resolver
uniprot_sec
Q8VI15
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by potassium cyanide, menadione, benzamidine, raloxifene and norharmane. {ECO:0000269|PubMed:11562361, ECO:0000269|PubMed:23019336}.
uniprot
proteins
amino_acid_sequence
MSPSKESDELIFFVNGKKVTERNADPEVNLLFYLRKVIRLTGTKYGCGGGDCGACTVMISRYDPISKRISHFSATACLVPICSLHGAAVTTVEGIGSTKTRIHPVQERIAKGHGTQCGFCTPGMVMSIYTLLRNHPEPSTEQIMETLGGNLCRCTGYRPIVESAKSFCPSSTCCQMNGEGKCCLDEEKNEPERKNSVCTKLYEKKEFQPLDPTQELIFPPELMRMAEESQNTVLTFRGERTTWIAPGTLNDLLELKMKHPSAPLVIGNTYLGLHMKFTDVSYPIIISPARILELFVVTNTKQGLTLGAGLSLTQVKNVLSDVVSRLPKEKTQIYCALLKQLKTLAGQQIRNVASLGGHIISRLPTSDLNPILGIGNCILNVASTEGIQQIPLNDHFLAGVPDAILKPEQVLISVFVPRSSKWEFVSAFRQAPRQQNAFATVNAGMKVVFKEDTNTITDLGILYGGIGATVISADKSCRQLIGRCWDEEMLDDAGKMICEEVSLLMAAPGGMEEYRKTLAISFLFMFYLDVLKQLKTRDPHKYPDISQKLLHILEDFPLTMPYGMQSFQDVDFQQPLQDPIGRPIMHQSGIKHATGEAVFCDDMSVLPGELFLAVVTSSKSHAKIISLDASEALASLGVVDVVTARDVPGDNGREEESLYAQDEVICVGQIVCAVAADSYAHAQQAAKKVKIVYQDIEPMIVTVQDALQYESFIGPERKLEQGNVEEAFQCADQILEGEVHLGGQEHFYMETQSVRVVPKGEDKEMDIYVSSQDAAFTQEMVARTLGIPKNRINCHVKRVGGAFGGKASKPGLLASVAAVAAQKTGRPIRFILERRDDMLITGGRHPLLGKYKIGFMNNGKIKAADIQLYINGGCTPDDSELVIEYALLKLENAYKIPNLRVRGRVCKTNLPSNTAFRGFGFPQGAFVTETCMSAVAAKCRLPPEKVRELNMYRTIDRTIHNQEFDPTNLLQCWEACVENSSYYNRKKAVDEFNQQRFWKKRGIAIIPMKFSVGFPKTFYYQAAALVQIYTDGSVLVAHGGVELGQGINTKMIQVASRELKIPMSYIHLDEMSTVTVPNTVTTGASTGADVNGRAVQNACQILMKRLEPIIKQNPSGTWEEWVKEAFVQSISLSATGYFRGYQADMDWEKGEGDIFPYFVFGAACSEVEIDCLTGAHKNIRTDIVMDGSFSINPAVDIGQIEGAFVQGLGLYTLEELKYSPEGVLYTRGPHQYKIASVTDIPEEFHVSLLTPTPNPKAIYSSKGLGEAGTFLGCSVFFAIAAAVAAAREERGLSPIWAINSPATAEVIRMACEDQFTNLVPQTDSKCCKPWSIPVA
uniprot
proteins
ec_number
1.17.3.-
uniprot
proteins
ec_number
1.2.3.1
uniprot
proteins
function
FUNCTION: Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and phthalazine, as well as aldehydes, such as benzaldehyde, retinal and pyridoxal. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. May also catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. {ECO:0000269|PubMed:11562361, ECO:0000269|PubMed:18981221, ECO:0000269|PubMed:21705476, ECO:0000269|PubMed:23019336}.
uniprot
proteins
mass_dalton
146902
uniprot
proteins
mutagenesis
MUTAGEN 807; /note="A->V: No effect on kinetic constants with smaller substrates like benzaldehyde or phthalazine. Decreases substrate affinity and slightly increases catalytic efficiency for bulkier substrates like phenanthridine."; /evidence="ECO:0000269|PubMed:23019336"; MUTAGEN 885; /note="Y->M: Slightly decreases substrate affinity but no effect on activity with smaller substrates like benzaldehyde or phthalazine. Increases catalytic efficiency with bulkier substrates like phenanthridine or more charged substrates like N1-methylnicotinamide."; /evidence="ECO:0000269|PubMed:23019336"; MUTAGEN 889; /note="K->H: No effect on substrate affinity but decreases catalytic efficiency for smaller substrates like benzaldehyde or phthalazine. Increases substrate affinity and activity for bulkier substrates like phenanthridine."; /evidence="ECO:0000269|PubMed:23019336"; MUTAGEN 1266; /note="E->Q: Loss of activity with different N-heterocyclic compounds as substrates. 60% reduction of activity with benzaldehyde."; /evidence="ECO:0000269|PubMed:23019336
uniprot
proteins
protein_family
Xanthine dehydrogenase family
uniprot
proteins
pubmed
11562361
uniprot
proteins
pubmed
15383531
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18981221
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21705476
uniprot
proteins
pubmed
23019336
uniprot
proteins
pubmed
23263164
uniprot
proteins
sequence_length
1335
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11562361, ECO:0000269|PubMed:15383531}.
uniprot
proteins