SLC45A4
entrez
57210
canonical
uniprot
Q5BKX6
canonical
ensembl
ENSG00000022567
resolver
ensp
ENSP00000024061
resolver
ensp
ENSP00000428137
resolver
ensp
ENSP00000429059
resolver
ensp
ENSP00000521822
resolver
ensp
ENSP00000607978
resolver
ensp
ENSP00000607979
resolver
enst
ENST00000517878
resolver
enst
ENST00000851763
resolver
enst
ENST00000937919
resolver
enst
ENST00000937920
resolver
genesymbol
SLC45A4
resolver
genesymbol_syn
KIAA1126
resolver
hgnc
HGNC:29196
resolver
uniprot
B2RXG1
resolver
uniprot
E7EV90
resolver
uniprot
Q6ZRI2
resolver
uniprot
Q9ULU3
resolver
uniprot_entry
B2RXG1_HUMAN
resolver
uniprot_entry
E7EV90_HUMAN
resolver
uniprot_entry
S45A4_HUMAN
resolver
uniprot_sec
Q6ZRI2
resolver
uniprot_sec
Q9ULU3
resolver
amino_acid_sequence
MKMAPQNADPESMQVQELSVPLPDPQKAGGAEAENCETISEGSIDRIPMRLWVMHGAVMFGREFCYAMETALVTPILLQIGLPEQYYSLTWFLSPILGLIFTPLIGSASDRCTLSWGRRRPFILALCVGVLFGVALFLNGSAIGLALGDVPNRQPIGIVLTVLGVVVLDFSADATEGPIRAYLLDVVDSEEQDMALNIHAFSAGLGGAIGYVLGGLDWTQTFLGSWFRTQNQVLFFFAAIIFTVSVALHLFSIDEEQYSPQQERSAEEPGALDGGEPHGVPAFPDEVQSEHELALDYPDVDIMRSKSDSALHVPDTALDLEPELLFLHDIEPSIFHDASYPATPRSTSQELAKTKLPRLATFLKEAAKEDETLLDNHLNEAKVPNGSGSPTKDALGGYTRVDTKPSATSSSMRRRRHAFRRQASSTFSYYGKLGSHCYRYRRANAVVLIKPSRSMSDLYDMQKRQRQHRHRNQSGATTSSGDTESEEGEGETTVRLLWLSMLKMPRELMRLCLCHLLTWFSVIAEAVFYTDFMGQVIFEGDPKAPSNSTAWQAYNAGVKMGCWGLVIYAATGAICSALLQKYLDNYDLSVRVIYVLGTLGFSVGTAVMAMFPNVYVAMVTISTMGIVSMSISYCPYALLGQYHDIKQYIHHSPGNSKRGFGIDCAILSCQVYISQILVASALGGVVDAVGTVRVIPMVASVGSFLGFLTATFLVIYPNVSEEAKEEQKGLSSPLAGEGRAGGNSEKPTVLKLTRKEGLQGPVETESVV
uniprot
proteins
function
FUNCTION: Neuronal polyamine-transporter involved in pain perception (PubMed:40836097, PubMed:41075780). Transports polyamines such as putrescine, cadaverine, spermine and spermidine (PubMed:40836097, PubMed:41075780). Expressed in sensory neuron subtypes within the dorsal root ganglion, where it regulates the excitability of C-polymodal nociceptors by mediating polyamine transport (By similarity). {ECO:0000250|UniProtKB:Q0P5V9, ECO:0000269|PubMed:40836097, ECO:0000269|PubMed:41075780}.
uniprot
proteins
mass_dalton
83878
uniprot
proteins
mutagenesis
MUTAGEN 63; /note="E->A: Abolished polyamine-transporter activity."; /evidence="ECO:0000269|PubMed:40836097"; MUTAGEN 66; /note="Y->A: Abolished polyamine-transporter activity."; /evidence="ECO:0000269|PubMed:40836097"; MUTAGEN 66; /note="Y->F: Does not affect the polyamine-transporter activity."; /evidence="ECO:0000269|PubMed:40836097"; MUTAGEN 169; /note="D->A: Abolished polyamine-transporter activity."; /evidence="ECO:0000269|PubMed:40836097"; MUTAGEN 173; /note="D->A: Abolished polyamine-transporter activity."; /evidence="ECO:0000269|PubMed:40836097"; MUTAGEN 176; /note="E->A: Abolished polyamine-transporter activity."; /evidence="ECO:0000269|PubMed:40836097"; MUTAGEN 450..453; /note="KPSR->EPSE: Does not affect the polyamine-transporter activity."; /evidence="ECO:0000269|PubMed:40836097"; MUTAGEN 519; /note="W->A,F: Decreased polyamine-transporter activity."; /evidence="ECO:0000269|PubMed:40836097"; MUTAGEN 672; /note="Y->A: Decreased polyamine-transporter activity."; /evidence="ECO:0000269|PubMed:40836097"; MUTAGEN 672; /note="Y->F: Slightly decreased polyamine-transporter activity."; /evidence="ECO:0000269|PubMed:40836097
uniprot
proteins
protein_family
Glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family
uniprot
proteins
pubmed
10574461
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
40836097
uniprot
proteins
pubmed
41075780
uniprot
proteins
sequence_length
768
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:40836097}; Multi-pass membrane protein {ECO:0000269|PubMed:40836097}.
uniprot
proteins
transmembrane_region
TRANSMEM 49..79; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:40836097, ECO:0007744|PDB:9GHZ, ECO:0007744|PDB:9GIU"; TRANSMEM 89..111; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:40836097, ECO:0007744|PDB:9GHZ, ECO:0007744|PDB:9GIU"; TRANSMEM 120..146; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:40836097, ECO:0007744|PDB:9GHZ, ECO:0007744|PDB:9GIU"; TRANSMEM 155..186; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:40836097, ECO:0007744|PDB:9GHZ, ECO:0007744|PDB:9GIU"; TRANSMEM 192..215; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:40836097, ECO:0007744|PDB:9GHZ, ECO:0007744|PDB:9GIU"; TRANSMEM 221..251; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:40836097, ECO:0007744|PDB:9GHZ, ECO:0007744|PDB:9GIU"; TRANSMEM 494..535; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:40836097, ECO:0007744|PDB:9GHZ, ECO:0007744|PDB:9GIU"; TRANSMEM 549..583; /note="Helical; Name=8"; /evidence="ECO:0000269|PubMed:40836097, ECO:0007744|PDB:9GHZ, ECO:0007744|PDB:9GIU"; TRANSMEM 590..610; /note="Helical; Name=9"; /evidence="ECO:0000269|PubMed:40836097, ECO:0007744|PDB:9GHZ, ECO:0007744|PDB:9GIU"; TRANSMEM 614..649; /note="Helical; Name=10"; /evidence="ECO:0000269|PubMed:40836097, ECO:0007744|PDB:9GHZ, ECO:0007744|PDB:9GIU"; TRANSMEM 660..689; /note="Helical; Name=11"; /evidence="ECO:0000269|PubMed:40836097, ECO:0007744|PDB:9GHZ, ECO:0007744|PDB:9GIU"; TRANSMEM 692..712; /note="Helical; Name=12"; /evidence="ECO:0000269|PubMed:40836097, ECO:0007744|PDB:9GHZ, ECO:0007744|PDB:9GIU
uniprot
proteins