Efna1
entrez
13636
canonical
uniprot
P52793
canonical
ensembl
ENSMUSG00000027954
resolver
ensp
ENSMUSP00000029566
resolver
ensp
ENSMUSP00000112904
resolver
enst
ENSMUST00000029566
resolver
enst
ENSMUST00000118587
resolver
genesymbol
Efna1
resolver
genesymbol_syn
Epgl1
resolver
genesymbol_syn
Epl1
resolver
genesymbol_syn
Lerk1
resolver
uniprot
D3YTT5
resolver
uniprot
P97331
resolver
uniprot
Q9D7K8
resolver
uniprot_entry
D3YTT5_MOUSE
resolver
uniprot_entry
EFNA1_MOUSE
resolver
uniprot_entry
Q9D7K8_MOUSE
resolver
uniprot_sec
P97331
resolver
amino_acid_sequence
MEFLWAPLLGLCCSLAAADRHIVFWNSSNPKFREEDYTVHVQLNDYLDIICPHYEDDSVADAAMERYTLYMVEHQEYVACQPQSKDQVRWNCNRPSAKHGPEKLSEKFQRFTPFILGKEFKEGHSYYYISKPIYHQESQCLKLKVTVNGKITHNPQAHVNPQEKRLQADDPEVQVLHSIGYSAAPRLFPLVWAVLLLPLLLLQSQ
uniprot
proteins
function
FUNCTION: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells (PubMed:16782872, PubMed:18387945, PubMed:20960543). Involved in angiogenesis, regulating vascular endothelial cell differentiation and migration through activation of EPHA2 (PubMed:16782872). Acts as a ligand for EPHA3, inhibiting epithelial-to-mesenchymal transition of cardiac cells and playing a role in heart development (PubMed:20960543). May also contribute to dendritic spine morphogenesis (PubMed:17143272). {ECO:0000269|PubMed:16782872, ECO:0000269|PubMed:17143272, ECO:0000269|PubMed:18387945, ECO:0000269|PubMed:20960543}.
uniprot
proteins
mass_dalton
23802
uniprot
proteins
post_translational_modification
PTM: Undergoes proteolysis by a metalloprotease to give rise to a soluble monomeric form. {ECO:0000250}.; PTM: N-Glycosylation is required for binding to EPHA2 receptor and inducing its internalization. {ECO:0000250|UniProtKB:P20827}.
uniprot
proteins
protein_family
Ephrin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16782872
uniprot
proteins
pubmed
17143272
uniprot
proteins
pubmed
18387945
uniprot
proteins
pubmed
20960543
uniprot
proteins
pubmed
27446912
uniprot
proteins
pubmed
7675446
uniprot
proteins
pubmed
8903354
uniprot
proteins
sequence_length
205
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P20827}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P20827}.; SUBCELLULAR LOCATION: [Ephrin-A1, secreted form]: Secreted {ECO:0000250|UniProtKB:P20827}.
uniprot
proteins