Cpne6
entrez
12891
canonical
uniprot
Q9Z140
canonical
ensembl
ENSMUSG00000022212
resolver
ensp
ENSMUSP00000073847
resolver
ensp
ENSMUSP00000126493
resolver
ensp
ENSMUSP00000128555
resolver
ensp
ENSMUSP00000132999
resolver
ensp
ENSMUSP00000165894
resolver
enst
ENSMUST00000074225
resolver
enst
ENSMUST00000163767
resolver
enst
ENSMUST00000165262
resolver
enst
ENSMUST00000171643
resolver
genesymbol
Cpne6
resolver
uniprot
F6XHV6
resolver
uniprot
Q3UYN2
resolver
uniprot_entry
CPNE6_MOUSE
resolver
uniprot_entry
F6XHV6_MOUSE
resolver
uniprot_entry
Q3UYN2_MOUSE
resolver
amino_acid_sequence
MSDPEMGWVPEPPAMTLGASRVELRVSCHGLLDRDTLTKPHPCVLLKLYSDEQWVEVERTEVLRSCSSPVFSRVLAIEYFFEEKQPLQFHVFDAEDGATSPSSDTFLGSTECTLGQIVSQTKVTKPLLLKNGKTAGKSTITIVAEEVSGTNDYVQLTFRAHKLDNKDLFSKSDPFMEIYKTNGDQSDQLVWRTEVVKNNLNPSWEPFRLSLHSLCSCDIHRPLKFLVYDYDSSGKHDFIGEFTSTFQEMQEGTANPGQEMQWDCINPKYRDKKKNYKSSGTVVLAQCTVEKVHTFLDYIMGGCQISFTVAIDFTASNGDPRSSQSLHCLSPRQPNHYLQALRTVGGICQDYDSDKRFPAFGFGARIPPNFEVSHDFAINFDPENPECEEISGVIASYRRCLPQIQLYGPTNVAPIINRVAEPAQREQSTGQATKYSVLLVLTDGVVSDMAETRTAIVRASRLPMSIIIVGVGNADFSDMRLLDGDDGPLRCPKGVPAARDIVQFVPFRDFKDAAPSALAKCVLAEVPRQVVEYYASQGISPGAPRPSTPAMTPSPSP
uniprot
proteins
function
FUNCTION: Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner (PubMed:9886090). Plays a role in dendrite formation by melanocytes (By similarity). {ECO:0000250|UniProtKB:O95741, ECO:0000269|PubMed:9886090}.
uniprot
proteins
mass_dalton
61781
uniprot
proteins
mutagenesis
MUTAGEN 33; /note="D->N: Does not inhibit calcium-dependent translocation to the cell membrane; when associated with N-35; N-93 and N-96."; /evidence="ECO:0000269|PubMed:26175110"; MUTAGEN 35; /note="D->N: Does not inhibit calcium-dependent translocation to the cell membrane; when associated with N-33; N-93 and N-96."; /evidence="ECO:0000269|PubMed:26175110"; MUTAGEN 93; /note="D->N: Does not inhibit calcium-dependent translocation to the cell membrane; when associated with N-33; N-35 and N-96."; /evidence="ECO:0000269|PubMed:26175110"; MUTAGEN 96; /note="D->N: Does not inhibit calcium-dependent translocation to the cell membrane; when associated with N-33; N-35 and N-93."; /evidence="ECO:0000269|PubMed:26175110"; MUTAGEN 167; /note="D->N: Inhibits strongly calcium-dependent translocation to the cell membrane. Inhibits strongly calcium-dependent translocation to the cell membrane; when associated with N-173. Leads to the constitutive (calcium-independent) attachment to the cell membrane; when associated with N-173; N-229 and N-231."; /evidence="ECO:0000269|PubMed:26175110"; MUTAGEN 173; /note="D->N: Inhibits strongly calcium-dependent translocation to the cell membrane. Inhibits strongly calcium-dependent translocation to the cell membrane; when associated with N-167. Leads to the constitutive (calcium-independent) attachment to the cell membrane; when associated with N-167; N-229 and N-231."; /evidence="ECO:0000269|PubMed:26175110"; MUTAGEN 229; /note="D->N: Inhibits strongly calcium-dependent translocation to the cell membrane; when associated with N-231. Leads to the constitutive (calcium-independent) attachment to the cell membrane; when associated with N-167; N-173 and N-231."; /evidence="ECO:0000269|PubMed:26175110"; MUTAGEN 231; /note="D->N: Does not inhibit calcium-dependent translocation to the cell membrane. Inhibits strongly calcium-dependent translocation to the cell membrane; when associated with N-229. Leads to the constitutive (calcium-independent) attachment to the cell membrane; when associated with N-167; N-173 and N-229."; /evidence="ECO:0000269|PubMed:26175110"; MUTAGEN 272; /note="K->A: Does not inhibit calcium-dependent translocation to the cell membrane; when associated with A-273 and A-274."; /evidence="ECO:0000269|PubMed:26175110"; MUTAGEN 273; /note="K->A: Does not inhibit calcium-dependent translocation to the cell membrane; when associated with A-272 and A-274."; /evidence="ECO:0000269|PubMed:26175110"; MUTAGEN 274; /note="K->A: Does not inhibit calcium-dependent translocation to the cell membrane; when associated with A-272 and A-273."; /evidence="ECO:0000269|PubMed:26175110"; MUTAGEN 282; /note="V->G: Does not inhibit calcium-dependent translocation to the cell membrane. Inhibits calcium-dependent translocation to the cell membrane; when associated with G-283 and G-284."; /evidence="ECO:0000269|PubMed:26175110"; MUTAGEN 282; /note="V->S: Inhibits calcium-dependent translocation to the cell membrane; when associated with S-283 and S-284."; /evidence="ECO:0000269|PubMed:26175110"; MUTAGEN 283; /note="V->G: Does not inhibit calcium-dependent translocation to the cell membrane. Inhibits calcium-dependent translocation to the cell membrane; when associated with G-282 and G-284."; /evidence="ECO:0000269|PubMed:26175110"; MUTAGEN 283; /note="V->S: Inhibits calcium-dependent translocation to the cell membrane; when associated with S-282 and S-284."; /evidence="ECO:0000269|PubMed:26175110"; MUTAGEN 284; /note="L->G: Inhibits partially calcium-dependent translocation to the cell membrane. Inhibits calcium-dependent translocation to the cell membrane; when associated with G-282 and G-283."; /evidence="ECO:0000269|PubMed:26175110"; MUTAGEN 284; /note="L->S: Inhibits calcium-dependent translocation to the cell membrane; when associated with S-282 and S-283."; /evidence="ECO:0000269|PubMed:26175110"; MUTAGEN 286; /note="Q->A: Does not inhibit calcium-dependent translocation to the cell membrane; when associated with G-287 and G-288."; /evidence="ECO:0000269|PubMed:26175110"; MUTAGEN 287; /note="C->A: Does not inhibit calcium-dependent translocation to the cell membrane; when associated with G-286 and G-288."; /evidence="ECO:0000269|PubMed:26175110"; MUTAGEN 288; /note="T->A: Does not inhibit calcium-dependent translocation to the cell membrane; when associated with G-286 and G-287."; /evidence="ECO:0000269|PubMed:26175110
uniprot
proteins
protein_family
Copine family
uniprot
proteins
pubmed
10403379
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21087455
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26175110
uniprot
proteins
pubmed
9645480
uniprot
proteins
pubmed
9886090
uniprot
proteins
sequence_length
557
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21087455, ECO:0000269|PubMed:9886090}. Cell membrane {ECO:0000269|PubMed:21087455, ECO:0000269|PubMed:26175110}. Endosome {ECO:0000269|PubMed:21087455}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:21087455}. Perikaryon {ECO:0000269|PubMed:9886090}. Cell projection, dendrite {ECO:0000269|PubMed:9886090}. Note=Mainly cytoplasmic in absence of calcium. Associated predominantly with membranes in presence of calcium (PubMed:9886090). Translocates to the cell membrane in a calcium-dependent manner (PubMed:21087455, PubMed:26175110). Colocalized with transferrin in intracellular clathrin-coated membrane vesicles in a calcium-dependent manner (PubMed:21087455). {ECO:0000269|PubMed:21087455, ECO:0000269|PubMed:26175110, ECO:0000269|PubMed:9886090}.
uniprot
proteins