PF4
entrez
5196
canonical
uniprot
P02776
canonical
ensembl
ENSG00000163737
resolver
ensp
ENSP00000296029
resolver
enst
ENST00000296029
resolver
genesymbol
PF4
resolver
genesymbol_syn
CXCL4
resolver
genesymbol_syn
SCYB4
resolver
hgnc
HGNC:8861
resolver
uniprot
Q53X61
resolver
uniprot
Q9UC64
resolver
uniprot
Q9UC65
resolver
uniprot_entry
PLF4_HUMAN
resolver
uniprot_sec
Q53X61
resolver
uniprot_sec
Q9UC64
resolver
uniprot_sec
Q9UC65
resolver
amino_acid_sequence
MSSAAGFCASRPGLLFLGLLLLPLVVAFASAEAEEDGDLQCLCVKTTSQVRPRHITSLEVIKAGPHCPTAQLIATLKNGRKICLDLQAPLYKKIIKKLLES
uniprot
proteins
function
FUNCTION: Chemokine released during platelet aggregation that plays a role in different biological processes including hematopoiesis, cell proliferation, differentiation, and activation (PubMed:29930254, PubMed:9531587). Acts via different functional receptors including CCR1, CXCR3A or CXCR3B (PubMed:18174362, PubMed:29930254). Upon interaction with CXCR3A receptor, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling (PubMed:18174362, PubMed:24469069). Neutralizes the anticoagulant effect of heparin by binding more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Plays a role in the inhibition of hematopoiesis and in the maintenance of hematopoietic stem cell (HSC) quiescence (PubMed:9531587). Chemotactic for neutrophils and monocytes via CCR1 (PubMed:29930254). Inhibits endothelial cell proliferation. In cooperation with toll-like receptor 8/TLR8, induces chromatin remodeling and activates inflammatory gene expression via the TBK1-IRF5 axis (PubMed:35701499). In addition, induces myofibroblast differentiation and collagen synthesis in different precursor cells, including endothelial cells, by stimulating endothelial-to-mesenchymal transition (PubMed:34986347). Interacts with thrombomodulin/THBD to enhance the activation of protein C and thus potentiates its anticoagulant activity (PubMed:9395524). {ECO:0000269|PubMed:18174362, ECO:0000269|PubMed:24469069, ECO:0000269|PubMed:29930254, ECO:0000269|PubMed:34986347, ECO:0000269|PubMed:35701499, ECO:0000269|PubMed:7644496, ECO:0000269|PubMed:9395524, ECO:0000269|PubMed:9531587}.
uniprot
proteins
mass_dalton
10845
uniprot
proteins
protein_family
Intercrine alpha (chemokine CxC) family
uniprot
proteins
pubmed
11468158
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
1695112
uniprot
proteins
pubmed
18174362
uniprot
proteins
pubmed
23536183
uniprot
proteins
pubmed
24469069
uniprot
proteins
pubmed
267922
uniprot
proteins
pubmed
27044744
uniprot
proteins
pubmed
29930254
uniprot
proteins
pubmed
3098319
uniprot
proteins
pubmed
34986347
uniprot
proteins
pubmed
35701499
uniprot
proteins
pubmed
601757
uniprot
proteins
pubmed
6445090
uniprot
proteins
pubmed
7547867
uniprot
proteins
pubmed
7644496
uniprot
proteins
pubmed
8031770
uniprot
proteins
pubmed
893407
uniprot
proteins
pubmed
9395524
uniprot
proteins
pubmed
9531587
uniprot
proteins
sequence_length
101
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7644496}.
uniprot
proteins