Itpkc
entrez
233011
canonical
uniprot
Q7TS72
canonical
ensembl
ENSMUSG00000003752
resolver
ensp
ENSMUSP00000003850
resolver
enst
ENSMUST00000003850
resolver
genesymbol
Itpkc
resolver
uniprot
Q3U384
resolver
uniprot_entry
IP3KC_MOUSE
resolver
uniprot_sec
Q3U384
resolver
activity_regulation
ACTIVITY REGULATION: Activated by calcium/calmodulin. Inhibited by high concentrations of the substrate Ins(1,2,4)P3, and allosterically activated by the product Ins(1,3,4,5)P4. {ECO:0000250|UniProtKB:Q96DU7}.
uniprot
proteins
amino_acid_sequence
MRRCPCRGSLSEAEAGALPAEARMGLEALRGGRRRQPGLQRPGPGAGGPTGRPEGGGPRAWIEESSLHSEAERTDLEPAPCPNGPQAESCGDGHAECEAAGLVVASEKPRQNKELDGSNLQTHPRRNSPLVEMEMAGSWTDGFRTDLHRSDLQSRPKRASLCTQPGFDESWTELDRSDMWQTLPERDNKPRVDNLRTHHGVSKLQTHPVCLSPESSADNSGKELSADASRTPHDTDGFWIESQTDDSLKGPSTQTACRQPGSDGFSSKDTESALTQPGTDGLRDDSVLGESNGNDPLDLSEPGELVTNLCSHLECSSLCPVPRLIITPETPEPEAQPVGPQSRIEGGTGGFSSASSFDESEDDLVAGGGGTSDPEDRAGSKPWKKLKTVLKYSPFVVSFHKHYYPWVQLSGHAGNFQAGEDGRILKRFCQCEQRSLELLMGDPLRPFVPAYYGMVQRDGQAFNQMEDLLADFEGPSIMDCKMGSRTYLEEELVKARERPKPRKDMYEKMVAVDPGAPTPEEHAQGAITKPRYMQWRETLSSTSTLGFRIEGIKKADGTCNTNFKKTQALEQVTKVLEDFVNGDLGILRKYVARLEDLRETLENSPFFKTHEVVGSSLLFVHDHTGLAKVWMIDFGKTVALPDHQMLSHRLPWTEGNREDGYLWGLDNLICLLQGLAQS
uniprot
proteins
ec_number
2.7.1.127
uniprot
proteins
function
FUNCTION: Catalyzes the phosphorylation of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) into 1D-myo-inositol 1,3,4,5-tetrakisphosphate and participates to the regulation of calcium homeostasis (By similarity). Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate (By similarity). {ECO:0000250|UniProtKB:Q80ZG2, ECO:0000250|UniProtKB:Q96DU7}.
uniprot
proteins
mass_dalton
74493
uniprot
proteins
protein_family
Inositol phosphokinase (IPK) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
678
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96DU7}. Cytoplasm {ECO:0000250|UniProtKB:Q96DU7}. Note=Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity. {ECO:0000250|UniProtKB:Q80ZG2}.
uniprot
proteins