P36380
uniprot
P36380
canonical
amino_acid_sequence
MNWGFLQGILSGVNKYSTALGRIWLSVVFIFRVLVYVVAAEEVWDDEQKDFICNTKQPGCPNVCYDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYREERERKHRLKHGPDAPALYSNLSKKRGGLWWTYLLSLIFKAAVDSGFLYIFHCIYKDYDMPRVVACSVQPCPHTVDCYISRPTEKKVFTYFMVVTAAICILLNLSEVAYLVGKRCMEVFRPRRQKTSRRHQLPDTCPPYVISKGHPQDESTVLTKAGMATVDAGVYP
uniprot
proteins
function
FUNCTION: Structural component of gap junctions (By similarity). Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity). Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (By similarity). {ECO:0000250|UniProtKB:P29033, ECO:0000250|UniProtKB:Q02738}.
uniprot
proteins
mass_dalton
30352
uniprot
proteins
protein_family
Beta-type (group I) subfamily
uniprot
proteins
protein_family
Connexin family
uniprot
proteins
pubmed
20184948
uniprot
proteins
pubmed
7517368
uniprot
proteins
sequence_length
265
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q02738}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q02738}. Cell junction, gap junction {ECO:0000250|UniProtKB:Q02738}. Note=Colocalizes with GJB2 at gap junction plaques in the cochlea. {ECO:0000250|UniProtKB:Q02738}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..40; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P29033"; TRANSMEM 74..94; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P29033"; TRANSMEM 131..151; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P29033"; TRANSMEM 185..205; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P29033
uniprot
proteins