Rad54b
entrez
623474
canonical
uniprot
Q6PFE3
canonical
ensembl
ENSMUSG00000078773
resolver
ensp
ENSMUSP00000066977
resolver
ensp
ENSMUSP00000092767
resolver
enst
ENSMUST00000070755
resolver
enst
ENSMUST00000095145
resolver
genesymbol
Rad54b
resolver
uniprot
A0A0A0MQB1
resolver
uniprot
A2AIV0
resolver
uniprot_entry
A0A0A0MQB1_MOUSE
resolver
uniprot_entry
RA54B_MOUSE
resolver
uniprot_sec
A2AIV0
resolver
amino_acid_sequence
MRRSAAPSQVQGKSFKKTRFIPPGRSNADVSKEITKMSPDPKLFQGAEQSQNDPGVCSSNPCPSEGIPREVGDGTRVDPLPPVHSASKEITESKAQEEEASSLLKYFSVVWCKASKKKHKKWEGDAILIVRGRSFTLKDLEGKDIGRGIGYKFKDLENVEEGQTLIIGGKEIEILGTISSDDFNSGKCFQHGSGSPAVPSSQAARKCFSNPFKSVCQSTQAQGKRWNDCRPRHNPCTPNALVMPRPDENHQRMFNRHCSPIVDVVIDPHLVHHLRPHQKDGIIFLYECVMGMRAVGKCGAILADEMGLGKTLQCISLIWTLQCQGPYGGKPVIKKTLIVTPGSLVNNWRKEFQKWLGSERIKIFTVDQDHKVEEFINSTFHSVLIISYEMLLRSLDQIKTIPFGLLICDEGHRLKNSSIKTTTALSSLSCEKTVILTGTPVQNDLQEFFALVDFVNPGILGSLSSYRKIYEEPIIISREPSSSKEERELGERRATELTRLTGRFILRRTQEVINKYLPPKIENVVFCRPGALQIELYRKLLRSQSVRFCLQGLLENSAHLICIGALKKLCNHPCLLFSSVKGKEFSSSCEENEERNLCQGLLSVFPAGYNPLQFSEEESGKLQVLVKLLAVIHELRPTEKVILVSNYRQTLNVLEEVCKRHGYACARLDGQTPVSQRQHIVDSFNSKYSTDFIFLLSSKAGGVGLNLIGGSHLILYDIDWNPATDIQAMSRVWRDGQKHPVHIYRLLTTGTIEEKIYQRQISKQGLSGAVVDLTRSSEHIQFSVEELKNLFTLHESSHCVTHDLLDCECTGEKGHTEDASEGPVASRQCQFGPQKSDALRPLSMSQLKQWKHFSGDHLNLPDPFLERIRENVSFFFQNITNQAPAV
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: Multifunctional ATPase that could play with RAD54, a redundant role in homologous recombination (HR), a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks. Could act as a molecular motor during the homology search and guide RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism (By similarity). Once DNA strand exchange occured, could dissociate RAD51 from nucleoprotein filaments formed on dsDNA (By similarity). May also function as a molecular adapter, promoting MDM2-MDM4 heterodimerization to facilitate the ubiquitin-dependent degradation of p53, thereby modulating the cellular decision between cell cycle arrest and progression in response to DNA damage (By similarity). {ECO:0000250|UniProtKB:P32863, ECO:0000250|UniProtKB:Q9Y620}.
uniprot
proteins
mass_dalton
99338
uniprot
proteins
protein_family
SNF2/RAD54 helicase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
886
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9Y620}. Note=Active at DNA double-strand breaks. {ECO:0000250|UniProtKB:Q9Y620}.
uniprot
proteins