Ccdc47
entrez
67163
canonical
uniprot
Q9D024
canonical
ensembl
ENSMUSG00000078622
resolver
ensp
ENSMUSP00000002043
resolver
genesymbol
Ccdc47
resolver
genesymbol_syn
Asp4
resolver
uniprot
B1AR94
resolver
uniprot
Q0VBU4
resolver
uniprot
Q3TSB5
resolver
uniprot
Q3V1S7
resolver
uniprot
Q8C5D9
resolver
uniprot
Q920S6
resolver
uniprot_entry
CCD47_MOUSE
resolver
uniprot_entry
Q0VBU4_MOUSE
resolver
uniprot_sec
B1AR94
resolver
uniprot_sec
Q3TSB5
resolver
uniprot_sec
Q3V1S7
resolver
uniprot_sec
Q8C5D9
resolver
uniprot_sec
Q920S6
resolver
amino_acid_sequence
MKAFYAFCVVLLVFGSVSEAKFDDFEDEEDIVEYDDNDFAEFEDVMEDSVTESPQRVISTEDDEDEATVELEGQDESQEGDFEDADTQEGDTESEPYDDEEFEGYEDKPDTSSNKNKDPITIVDVPAHLQNSWESYYLEILMVTGLLAYIMNYIIGKNKNSRLAQAWFNSHRELLESNFTLVGDDGTNKEATSTGKLNQENEHIYNLWCSGRVCCEGMLIQLRFLKRQDLLNVLARMMRPVSDQVQIKVTMNDEDMDTYVFAVGTRKALLRLQKEMQDLSEFCSDKPKSGAKYGLPDSLAILSEMGEVTEGMMDTKMVHFLTHYADKIESVHFSDQFSGPKIMQEEGQPLKLPDTKRTLLFTFNVPGSGNTYPKDMESLLPLMNMVIYSIDKAKKFRLNREGKQKADKNRARVEENFLKLTHVQRQEAAQSRREEKKRAEKERIMNEEDPEKQRRLEEAALRREQKKLEKKQMKMKQIKVKAM
uniprot
proteins
function
FUNCTION: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes (By similarity). The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions (By similarity). Within the MPT complex, the PAT subcomplex sequesters any highly polar regions in the transmembrane domains away from the non-polar membrane environment until they can be buried in the interior of the fully assembled protein (By similarity). Within the PAT subcomplex, CCDC47 occludes the lateral gate of the SEC61 complex (By similarity). Involved in the regulation of calcium ion homeostasis in the ER (By similarity). Required for proper protein degradation via the ERAD (ER-associated degradation) pathway (By similarity). Has an essential role in the maintenance of ER organization during embryogenesis (PubMed:25009997). {ECO:0000250|UniProtKB:A0A8I3P7X4, ECO:0000250|UniProtKB:Q96A33, ECO:0000269|PubMed:25009997}.
uniprot
proteins
mass_dalton
55844
uniprot
proteins
protein_family
CCDC47 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25009997
uniprot
proteins
sequence_length
483
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q96A33}; Single-pass type I membrane protein {ECO:0000255}. Rough endoplasmic reticulum membrane {ECO:0000269|PubMed:25009997}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 136..156; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins