TBC1D3E
entrez
102723859
canonical
uniprot
A0A087X179
canonical
ensembl
ENSG00000278599
resolver
ensp
ENSP00000483965
resolver
enst
ENST00000621587
resolver
genesymbol
TBC1D3E
resolver
hgnc
HGNC:27071
resolver
uniprot_entry
TBC3E_HUMAN
resolver
amino_acid_sequence
MDVVEVAGSWWAQEREDIIMKYEKGHRAGLPEDKGPKPFRSYNNNVDHLGIVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDQAYKGMPMNIRGPMWSVLLNTEEMKLKNPGRYQIMKEKGKKSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQEHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASMKKLTRKKGDLPPPAKPEQGSSASRPVPASRGGKTLCKGDRQAPPGPPARFPRPIWSASPPRAPRSSTPCPGGAVREDTYPVGTQGVPSPALAQGGPQGSWRFLQWNSMPRLPTDLDVEGPWFRHYDFRQSCWVRAISQEDQLAPCWQAEHPAERVRSAFAAPSTDSDQGTPFRARDEQQCAPTSGPCLCGLHLESSQFPPGF
uniprot
proteins
function
FUNCTION: Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity). {ECO:0000250|UniProtKB:Q8IZP1}.
uniprot
proteins
mass_dalton
62131
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by a CUL7-based E3 ligase, which leads to proteasomal degradation. {ECO:0000250|UniProtKB:Q8IZP1}.; PTM: Palmitoylation is required for membrane localization and protects TBC1D3 from ubiquitination. {ECO:0000250|UniProtKB:Q8IZP1}.
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16863688
uniprot
proteins
pubmed
21030649
uniprot
proteins
sequence_length
549
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8IZP1}; Lipid-anchor {ECO:0000250|UniProtKB:Q8IZP1}. Note=Associated with lipid rafts. {ECO:0000250|UniProtKB:Q8IZP1}.
uniprot
proteins