OS9
entrez
10956
canonical
uniprot
Q13438
canonical
ensembl
ENSG00000135506
resolver
ensp
ENSP00000257966
resolver
ensp
ENSP00000318165
resolver
ensp
ENSP00000373794
resolver
ensp
ENSP00000373798
resolver
ensp
ENSP00000389632
resolver
ensp
ENSP00000407360
resolver
ensp
ENSP00000447866
resolver
ensp
ENSP00000450010
resolver
ensp
ENSP00000515128
resolver
ensp
ENSP00000515130
resolver
ensp
ENSP00000515134
resolver
enst
ENST00000700659
resolver
enst
ENST00000700661
resolver
enst
ENST00000700665
resolver
genesymbol
OS9
resolver
hgnc
HGNC:16994
resolver
uniprot
A0A8V8TPZ4
resolver
uniprot
A0A8V8TQI8
resolver
uniprot
A0A8V8TR34
resolver
uniprot
A6NDD1
resolver
uniprot
A6NFR7
resolver
uniprot
A6NLB2
resolver
uniprot
A8K5Q9
resolver
uniprot
B4DE28
resolver
uniprot
B4DPX1
resolver
uniprot
B4E1I6
resolver
uniprot
E7ENT8
resolver
uniprot
E7EW91
resolver
uniprot
F8VUH2
resolver
uniprot
G3XA88
resolver
uniprot
O00579
resolver
uniprot
Q6IBL2
resolver
uniprot
Q8IZ58
resolver
uniprot
Q9BW99
resolver
uniprot_entry
A0A8V8TPZ4_HUMAN
resolver
uniprot_entry
A0A8V8TQI8_HUMAN
resolver
uniprot_entry
A0A8V8TR34_HUMAN
resolver
uniprot_entry
OS9_HUMAN
resolver
uniprot_sec
A6NDD1
resolver
uniprot_sec
A6NFR7
resolver
uniprot_sec
A6NLB2
resolver
uniprot_sec
A8K5Q9
resolver
uniprot_sec
B4DE28
resolver
uniprot_sec
B4DPX1
resolver
uniprot_sec
B4E1I6
resolver
uniprot_sec
E7ENT8
resolver
uniprot_sec
E7EW91
resolver
uniprot_sec
F8VUH2
resolver
uniprot_sec
G3XA88
resolver
uniprot_sec
O00579
resolver
uniprot_sec
Q6IBL2
resolver
uniprot_sec
Q8IZ58
resolver
uniprot_sec
Q9BW99
resolver
amino_acid_sequence
MAAETLLSSLLGLLLLGLLLPASLTGGVGSLNLEELSEMRYGIEILPLPVMGGQSQSSDVVIVSSKYKQRYECRLPAGAIHFQREREEETPAYQGPGIPELLSPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDSEIKGEVLYLGYYQSAFDWDDETAKASKQHRLKRYHSQTYGNGSKCDLNGRPREAEVRFLCDEGAGISGDYIDRVDEPLSCSYVLTIRTPRLCPHPLLRPPPSAAPQAILCHPSLQPEEYMAYVQRQADSKQYGDKIIEELQDLGPQVWSETKSGVAPQKMAGASPTKDDSKDSDFWKMLNEPEDQAPGGEEVPAEEQDPSPEAADSASGAPNDFQNNVQVKVIRSPADLIRFIEELKGGTKKGKPNIGQEQPVDDAAEVPQREPEKERGDPERQREMEEEEDEDEDEDEDEDERQLLGEFEKELEGILLPSDRDRLRSEVKAGMERELENIIQETEKELDPDGLKKESERDRAMLALTSTLNKLIKRLEEKQSPELVKKHKKKRVVPKKPPPSPQPTEEDPEHRVRVRVTKLRLGGPNQDLTVLEMKRENPQLKQIEGLVKELLEREGLTAAGKIEIKIVRPWAEGTEEGARWLTDEDTRNLKEIFFNILVPGAEEAQKERQRQKELESNYRRVWGSPGGEGTGDLDEFDF
uniprot
proteins
function
FUNCTION: Lectin component of the HRD1 complex, which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD) (PubMed:18264092, PubMed:18417469, PubMed:19084021, PubMed:19346256, PubMed:21172656, PubMed:24899641). Specifically recognizes and binds improperly folded glycoproteins as well as hyperglycosylated proteins, retain them in the ER, and transfers them to the ubiquitination machinery and promote their degradation (PubMed:18264092, PubMed:18417469, PubMed:19084021, PubMed:19346256, PubMed:21172656, PubMed:24899641). Possible targets include TRPV4 as well as hyperglycosylated HSP90B1 (PubMed:17932042). {ECO:0000269|PubMed:17932042, ECO:0000269|PubMed:18264092, ECO:0000269|PubMed:18417469, ECO:0000269|PubMed:19084021, ECO:0000269|PubMed:19346256, ECO:0000269|PubMed:21172656, ECO:0000269|PubMed:24899641}.
uniprot
proteins
mass_dalton
75562
uniprot
proteins
mutagenesis
MUTAGEN 188; /note="R->A: Loss of glycan-binding activity and partial inhibition of ERAD of the misfolded glycoprotein NHK (PubMed:19346256). Reduced interaction with SEL1L (PubMed:18264092) not confirmed in (PubMed:19346256)."; /evidence="ECO:0000269|PubMed:18264092, ECO:0000269|PubMed:18417469, ECO:0000269|PubMed:19346256
uniprot
proteins
post_translational_modification
PTM: Intramolecular disulfide bonds. {ECO:0000269|PubMed:18417469}.; PTM: Isoform 1 and isoform 2 are N-glycosylated. {ECO:0000269|PubMed:18264092, ECO:0000269|PubMed:18417469, ECO:0000269|PubMed:19084021}.
uniprot
proteins
protein_family
OS-9 family
uniprot
proteins
pubmed
10403379
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17932042
uniprot
proteins
pubmed
18264092
uniprot
proteins
pubmed
18417469
uniprot
proteins
pubmed
18502753
uniprot
proteins
pubmed
19084021
uniprot
proteins
pubmed
19346256
uniprot
proteins
pubmed
20546900
uniprot
proteins
pubmed
21172656
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24899641
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28827405
uniprot
proteins
pubmed
8634085
uniprot
proteins
pubmed
9192850
uniprot
proteins
pubmed
9498564
uniprot
proteins
pubmed
9562620
uniprot
proteins
sequence_length
667
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:18264092, ECO:0000269|PubMed:18417469, ECO:0000269|PubMed:19084021}.
uniprot
proteins