SEPTIN2
entrez
4735
canonical
uniprot
Q15019
canonical
ensembl
ENSG00000168385
resolver
ensp
ENSP00000353157
resolver
ensp
ENSP00000375832
resolver
ensp
ENSP00000375834
resolver
ensp
ENSP00000384525
resolver
ensp
ENSP00000385109
resolver
ensp
ENSP00000385172
resolver
ensp
ENSP00000479861
resolver
ensp
ENSP00000546254
resolver
ensp
ENSP00000546256
resolver
ensp
ENSP00000546257
resolver
ensp
ENSP00000546262
resolver
ensp
ENSP00000546264
resolver
ensp
ENSP00000546266
resolver
ensp
ENSP00000546267
resolver
ensp
ENSP00000546275
resolver
ensp
ENSP00000546276
resolver
ensp
ENSP00000546279
resolver
ensp
ENSP00000589319
resolver
ensp
ENSP00000615292
resolver
ensp
ENSP00000615295
resolver
ensp
ENSP00000615296
resolver
ensp
ENSP00000615300
resolver
enst
ENST00000407971
resolver
genesymbol
SEPTIN2
resolver
genesymbol_syn
DIFF6
resolver
genesymbol_syn
KIAA0158
resolver
genesymbol_syn
NEDD5
resolver
genesymbol_syn
SEPT2
resolver
hgnc
HGNC:7729
resolver
uniprot
A0A384N6H6
resolver
uniprot
B4DGE8
resolver
uniprot
B5MCX3
resolver
uniprot
Q14132
resolver
uniprot
Q53QU3
resolver
uniprot
Q8IUK9
resolver
uniprot
Q96CB0
resolver
uniprot_entry
A0A384N6H6_HUMAN
resolver
uniprot_entry
B5MCX3_HUMAN
resolver
uniprot_entry
SEPT2_HUMAN
resolver
uniprot_sec
B4DGE8
resolver
uniprot_sec
Q14132
resolver
uniprot_sec
Q53QU3
resolver
uniprot_sec
Q8IUK9
resolver
uniprot_sec
Q96CB0
resolver
amino_acid_sequence
MSKQQPTQFINPETPGYVGFANLPNQVHRKSVKKGFEFTLMVVGESGLGKSTLINSLFLTDLYPERVIPGAAEKIERTVQIEASTVEIEERGVKLRLTVVDTPGYGDAINCRDCFKTIISYIDEQFERYLHDESGLNRRHIIDNRVHCCFYFISPFGHGLKPLDVAFMKAIHNKVNIVPVIAKADTLTLKERERLKKRILDEIEEHNIKIYHLPDAESDEDEDFKEQTRLLKASIPFSVVGSNQLIEAKGKKVRGRLYPWGVVEVENPEHNDFLKLRTMLITHMQDLQEVTQDLHYENFRSERLKRGGRKVENEDMNKDQILLEKEAELRRMQEMIARMQAQMQMQMQGGDGDGGALGHHV
uniprot
proteins
function
FUNCTION: Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. {ECO:0000269|PubMed:15774761, ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18209106, ECO:0000269|PubMed:19145258, ECO:0000305|PubMed:25588830}.
uniprot
proteins
mass_dalton
41487
uniprot
proteins
mutagenesis
MUTAGEN 156; /note="F->D: Loss of dimerization."; /evidence="ECO:0000269|PubMed:17637674"; MUTAGEN 218; /note="S->A: Loss of phosphorylation."; /evidence="ECO:0000269|PubMed:19165576"; MUTAGEN 260; /note="W->A: Loss of dimerization."; /evidence="ECO:0000269|PubMed:17637674"; MUTAGEN 270; /note="H->D: Loss of dimerization."; /evidence="ECO:0000269|PubMed:17637674
uniprot
proteins
protein_family
Septin GTPase family
uniprot
proteins
protein_family
TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15150837
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15774761
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
15915442
uniprot
proteins
pubmed
16093351
uniprot
proteins
pubmed
16914550
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17637674
uniprot
proteins
pubmed
17803907
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18209106
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19145258
uniprot
proteins
pubmed
19165576
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25588830
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28346465
uniprot
proteins
pubmed
28530676
uniprot
proteins
pubmed
38870534
uniprot
proteins
pubmed
8590280
uniprot
proteins
pubmed
8697812
uniprot
proteins
sequence_length
361
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15774761}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15774761}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15774761}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:15774761}. Cleavage furrow {ECO:0000269|PubMed:15774761}. Midbody {ECO:0000269|PubMed:15774761}. Cytoplasm, cell cortex {ECO:0000269|PubMed:15774761}. Cell projection, cilium membrane {ECO:0000250}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:25588830}. Note=In metaphase cells, localized within the microtubule spindle. At the metaphase plate, in close apposition to the kinetochores of the congressed chromosomes. In cells undergoing cytokinesis, localized to the midbody, the ingressing cleavage furrow, and the central spindle. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria. In epithelial cells, colocalizes with polyglutamylated tubulin around the trans-Golgi network, as well as juxatnuclear and proximal Golgi apparatus. Localizes at the base of the cilia near the morphological distinction between the cilia and plasma membranes. Expressed in the sperm annulus, neck and tail (PubMed:25588830). {ECO:0000269|PubMed:25588830}.
uniprot
proteins