Fa2h
entrez
307855
canonical
uniprot
Q2LAM0
canonical
ensembl
ENSRNOG00000018950
resolver
ensembl
ENSRNOG00055020458
resolver
ensembl
ENSRNOG00060011613
resolver
ensembl
ENSRNOG00065012627
resolver
ensp
ENSRNOP00000025625
resolver
ensp
ENSRNOP00055028337
resolver
ensp
ENSRNOP00060015476
resolver
ensp
ENSRNOP00065015810
resolver
enst
ENSRNOT00055034926
resolver
enst
ENSRNOT00060019660
resolver
enst
ENSRNOT00065020557
resolver
genesymbol
Fa2h
resolver
genesymbol_syn
Faah
resolver
uniprot_entry
FA2H_RAT
resolver
amino_acid_sequence
MAPAPPPAASFTSAEVQRRLAAGACWVRRGASLYDLTGFVRHHPGGEQLLLARAGQDISADLDGPPHKHSDNARRWLEQYYVGELRADPQDPTENGAGAPAETQKTDAAIEPQFKVVDWDKDLVDWQKPLLWQVGHLGEKYDEWVHQPVARPIRLFHSDLIEAFSKTVWYSVPIIWVPLVLYLSWSYYRTLTQDNIRLFASFTRDYSLVVPESVFIGLFVLGMLIWTLVEYLIHRFLFHMKPPSNSHYLIMLHFVMHGQHHKAPFDGSRLVFPPVPASVVVAFFYVFLRLILPEAVAGILFAGGLLGYVLYDMTHYYLHFGSPHKGSYLYNMKAHHVKHHFEYQKSGFGISTKLWDYFFHTLIPEEADPKMQ
uniprot
proteins
ec_number
1.14.18.-
uniprot
proteins
function
FUNCTION: Catalyzes the hydroxylation of free fatty acids at the C-2 position to produce 2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis (Probable). FA2H is stereospecific for the production of (R)-2-hydroxy fatty acids (By similarity). Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath (PubMed:17901466). Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier (By similarity). Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins (By similarity). {ECO:0000250|UniProtKB:Q5MPP0, ECO:0000250|UniProtKB:Q7L5A8, ECO:0000269|PubMed:17901466, ECO:0000305|PubMed:17901466}.
uniprot
proteins
mass_dalton
42673
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid metabolism. {ECO:0000269|PubMed:17901466}.; PATHWAY: Sphingolipid metabolism; galactosylceramide biosynthesis. {ECO:0000269|PubMed:17901466}.
uniprot
proteins
protein_family
SCS7 subfamily
uniprot
proteins
protein_family
Sterol desaturase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16998236
uniprot
proteins
pubmed
17901466
uniprot
proteins
sequence_length
372
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q7L5A8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7L5A8}. Microsome membrane {ECO:0000250|UniProtKB:Q7L5A8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7L5A8}.
uniprot
proteins
transmembrane_region
TRANSMEM 168..188; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 213..233; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 268..288; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 290..310; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins