Kcnn3
entrez
140493
canonical
uniprot
P58391
canonical
ensembl
ENSMUSG00000000794
resolver
ensp
ENSMUSP00000000811
resolver
enst
ENSMUST00000000811
resolver
genesymbol
Kcnn3
resolver
genesymbol_syn
Sk3
resolver
uniprot
Q3UUY9
resolver
uniprot_entry
KCNN3_MOUSE
resolver
uniprot_sec
Q3UUY9
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by bee venom neurotoxin apamin. {ECO:0000269|PubMed:11557517}.
uniprot
proteins
amino_acid_sequence
MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQPPPPPAPPAVPQQPPGPLLQPQPPQPQQQQSQQQQQQQSQQQQQQAPLHPLPQLAQLQSQLVHPGLLHSSPTAFRAPTSANSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAEPEGQPLQLFSPSNPPEIIISSREDNHAHQTLLHHPNATHNHQHAGTTAGSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTVILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRGVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLTAFVEARGISVAVGTSHAPPSDSPIGISSTSFPTPYTSSSSC
uniprot
proteins
function
FUNCTION: Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening (PubMed:11557517). The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of 10 picosiemens (PubMed:11557517). Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values, above + 20 mV (By similarity). Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization (By similarity). {ECO:0000250|UniProtKB:P70605, ECO:0000250|UniProtKB:Q9UGI6, ECO:0000269|PubMed:11557517}.
uniprot
proteins
mass_dalton
81333
uniprot
proteins
protein_family
KCa2.3/KCNN3 subfamily
uniprot
proteins
protein_family
Potassium channel KCNN family
uniprot
proteins
pubmed
11557517
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16055520
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20689065
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
732
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11557517}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:20689065}.
uniprot
proteins
transmembrane_region
TRANSMEM 289..309; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 316..336; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 367..387; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 406..426; /note="Helical; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 455..475; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 524..544; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins