SLC46A2
entrez
57864
canonical
uniprot
Q9BY10
canonical
ensembl
ENSG00000119457
resolver
ensp
ENSP00000363345
resolver
ensp
ENSP00000474847
resolver
enst
ENST00000374228
resolver
enst
ENST00000491462
resolver
genesymbol
SLC46A2
resolver
genesymbol_syn
TSCOT
resolver
hgnc
HGNC:16055
resolver
uniprot
B1ALK1
resolver
uniprot
Q86VT0
resolver
uniprot
Q96NE2
resolver
uniprot
S4R3Y2
resolver
uniprot_entry
S46A2_HUMAN
resolver
uniprot_entry
S4R3Y2_HUMAN
resolver
uniprot_sec
B1ALK1
resolver
uniprot_sec
Q86VT0
resolver
uniprot_sec
Q96NE2
resolver
amino_acid_sequence
MSPEVTCPRRGHLPRFHPRTWVEPVVASSQVAASLYDAGLLLVVKASYGTGGSSNHSASPSPRGALEDQQQRAISNFYIIYNLVVGLSPLLSAYGLGWLSDRYHRKISICMSLLGFLLSRLGLLLKVLLDWPVEVLYGAAALNGLFGGFSAFWSGVMALGSLGSSEGRRSVRLILIDLMLGLAGFCGSMASGHLFKQMAGHSGQGLILTACSVSCASFALLYSLLVLKVPESVAKPSQELPAVDTVSGTVGTYRTLDPDQLDQQYAVGHPPSPGKAKPHKTTIALLFVGAIIYDLAVVGTVDVIPLFVLREPLGWNQVQVGYGMAAGYTIFITSFLGVLVFSRCFRDTTMIMIGMVSFGSGALLLAFVKETYMFYIARAVMLFALIPVTTIRSAMSKLIKGSSYGKVFVILQLSLALTGVVTSTLYNKIYQLTMDMFVGSCFALSSFLSFLAIIPISIVAYKQVPLSPYGDIIEK
uniprot
proteins
function
FUNCTION: Proton-coupled transporter that delivers pathogen-associated or danger-associated molecular patterns to cytosolic pattern recognition receptors as part of the innate immune response to microbes or tissue injury (PubMed:28539433, PubMed:34235268). Has selectivity toward muropeptides that contain the amino acid diaminopimelic acid (DAP-type peptidoglycan muropeptides) including Tri-DAP and tracheal toxin (TCT), common in Gram-negative bacteria and Gram-positive bacilli. In the context of immune recognition of skin microbiota, shuttles bacterial muropeptides across the endolysosomal membranes into the cytosol for recognition by NOD1, triggering MYD88-dependent secretion of IL1A and neutrophil recruitment in a pyroptosis-type inflammatory process (PubMed:28539433). To a lesser extent and redundantly, transports muramyl dipeptides derived from most bacterial proteoglycans, eliciting NOD2 receptor activation and downstream inflammatory responses (PubMed:28539433). Postulated to function as a dominant importer of cyclic GMP-AMP dinucleotides (cGAMPs) in monocyte and macrophage cell lineages. Selectively imports cGAMPs derived from pathogenic bacteria such as 3'3'-cGAMP thus providing for differential immune recognition of pathogenic versus commensal bacteria. During tumorigenesis may transport extracellular tumor-derived 2'3'-cGAMP across the plasma membrane of M1-polarized macrophages to activate the anti-tumoral stimulator of interferon genes (STING) pathway (PubMed:34235268). The transport mechanism, its electrogenicity and stoichiometry remain to be elucidated (Probable). {ECO:0000269|PubMed:28539433, ECO:0000269|PubMed:34235268, ECO:0000305}.
uniprot
proteins
mass_dalton
51067
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250}.
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
SLC46A family
uniprot
proteins
pubmed
10978518
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
28539433
uniprot
proteins
pubmed
34235268
uniprot
proteins
pubmed
37116499
uniprot
proteins
sequence_length
475
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:28539433}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:34235268}; Multi-pass membrane protein. Note=Localizes in acidic vesicles likely late endosomes and/or endolysosomes. {ECO:0000269|PubMed:28539433}.
uniprot
proteins
transmembrane_region
TRANSMEM 24..44; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 79..99; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 109..129; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 139..159; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 173..193; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 206..226; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 283..303; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 321..341; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 348..368; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 371..391; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 407..427; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 436..456; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins