RIOK1
entrez
83732
canonical
uniprot
Q9BRS2
canonical
ensembl
ENSG00000124784
resolver
ensp
ENSP00000369162
resolver
ensp
ENSP00000545595
resolver
enst
ENST00000379834
resolver
enst
ENST00000875536
resolver
genesymbol
RIOK1
resolver
genesymbol_syn
RIO1
resolver
hgnc
HGNC:18656
resolver
uniprot
B2RB28
resolver
uniprot
Q8NDC8
resolver
uniprot
Q96NV9
resolver
uniprot_entry
RIOK1_HUMAN
resolver
uniprot_sec
B2RB28
resolver
uniprot_sec
Q8NDC8
resolver
uniprot_sec
Q96NV9
resolver
amino_acid_sequence
MDYRRLLMSRVVPGQFDDADSSDSENRDLKTVKEKDDILFEDLQDNVNENGEGEIEDEEEEGYDDDDDDWDWDEGVGKLAKGYVWNGGSNPQANRQTSDSSSAKMSTPADKVLRKFENKINLDKLNVTDSVINKVTEKSRQKEADMYRIKDKADRATVEQVLDPRTRMILFKMLTRGIITEINGCISTGKEANVYHASTANGESRAIKIYKTSILVFKDRDKYVSGEFRFRHGYCKGNPRKMVKTWAEKEMRNLIRLNTAEIPCPEPIMLRSHVLVMSFIGKDDMPAPLLKNVQLSESKARELYLQVIQYMRRMYQDARLVHADLSEFNMLYHGGGVYIIDVSQSVEHDHPHALEFLRKDCANVNDFFMRHSVAVMTVRELFEFVTDPSITHENMDAYLSKAMEIASQRTKEERSSQDHVDEEVFKRAYIPRTLNEVKNYERDMDIIMKLKEEDMAMNAQQDNILYQTVTGLKKDLSGVQKVPALLENQVEERTCSDSEDIGSSECSDTDSEEQGDHARPKKHTTDPDIDKKERKKMVKEAQREKRKNKIPKHVKKRKEKTAKTKKGK
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
ec_number
3.6.1.-
uniprot
proteins
function
FUNCTION: Involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in processing of 18S-E pre-rRNA to the mature 18S rRNA. Required for the recycling of NOB1 and PNO1 from the late 40S precursor (PubMed:22072790). The association with the very late 40S subunit intermediate may involve a translation-like checkpoint point cycle preceeding the binding to the 60S ribosomal subunit (By similarity). Despite the protein kinase domain is proposed to act predominantly as an ATPase (By similarity). The catalytic activity regulates its dynamic association with the 40S subunit (By similarity). In addition to its role in ribosomal biogenesis acts as an adapter protein by recruiting NCL/nucleolin the to PRMT5 complex for its symmetrical methylation (PubMed:21081503). {ECO:0000250|UniProtKB:G0S3J5, ECO:0000250|UniProtKB:Q12196, ECO:0000269|PubMed:21081503, ECO:0000269|PubMed:22072790}.
uniprot
proteins
mass_dalton
65583
uniprot
proteins
mutagenesis
MUTAGEN 324; /note="D->A: Abolishes autophosphorylation activity; enhances association with pre-40S ribosomal subunits; inhibits processing of 18S-E pre-rRNA to the mature 18S rRNA."; /evidence="ECO:0000269|PubMed:22072790
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
RIO-type Ser/Thr kinase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21081503
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22072790
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24948609
uniprot
proteins
sequence_length
568
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:21081503}.
uniprot
proteins