PLXNB2
entrez
23654
canonical
uniprot
O15031
canonical
ensembl
ENSG00000196576
resolver
ensp
ENSP00000352288
resolver
ensp
ENSP00000409171
resolver
ensp
ENSP00000560291
resolver
ensp
ENSP00000560292
resolver
ensp
ENSP00000560293
resolver
ensp
ENSP00000560294
resolver
ensp
ENSP00000560295
resolver
ensp
ENSP00000560296
resolver
ensp
ENSP00000560297
resolver
ensp
ENSP00000560298
resolver
ensp
ENSP00000560299
resolver
ensp
ENSP00000560300
resolver
ensp
ENSP00000600966
resolver
ensp
ENSP00000600967
resolver
ensp
ENSP00000600968
resolver
ensp
ENSP00000600969
resolver
ensp
ENSP00000600970
resolver
ensp
ENSP00000600971
resolver
ensp
ENSP00000600972
resolver
ensp
ENSP00000600973
resolver
ensp
ENSP00000600974
resolver
ensp
ENSP00000600975
resolver
ensp
ENSP00000600976
resolver
ensp
ENSP00000600977
resolver
ensp
ENSP00000619317
resolver
enst
ENST00000359337
resolver
enst
ENST00000449103
resolver
enst
ENST00000890232
resolver
enst
ENST00000890233
resolver
enst
ENST00000890234
resolver
enst
ENST00000890235
resolver
enst
ENST00000890236
resolver
enst
ENST00000890237
resolver
enst
ENST00000890238
resolver
enst
ENST00000890239
resolver
enst
ENST00000890240
resolver
enst
ENST00000890241
resolver
enst
ENST00000930907
resolver
enst
ENST00000930908
resolver
enst
ENST00000930909
resolver
enst
ENST00000930910
resolver
enst
ENST00000930911
resolver
enst
ENST00000930912
resolver
enst
ENST00000930913
resolver
enst
ENST00000930915
resolver
enst
ENST00000930916
resolver
enst
ENST00000930917
resolver
enst
ENST00000930918
resolver
enst
ENST00000949258
resolver
genesymbol
PLXNB2
resolver
genesymbol_syn
KIAA0315
resolver
hgnc
HGNC:9104
resolver
uniprot
A6QRH0
resolver
uniprot
Q7KZU3
resolver
uniprot
Q9BSU7
resolver
uniprot_entry
PLXB2_HUMAN
resolver
uniprot_sec
A6QRH0
resolver
uniprot_sec
Q7KZU3
resolver
uniprot_sec
Q9BSU7
resolver
amino_acid_sequence
MALQLWALTLLGLLGAGASLRPRKLDFFRSEKELNHLAVDEASGVVYLGAVNALYQLDAKLQLEQQVATGPALDNKKCTPPIEASQCHEAEMTDNVNQLLLLDPPRKRLVECGSLFKGICALRALSNISLRLFYEDGSGEKSFVASNDEGVATVGLVSSTGPGGDRVLFVGKGNGPHDNGIIVSTRLLDRTDSREAFEAYTDHATYKAGYLSTNTQQFVAAFEDGPYVFFVFNQQDKHPARNRTLLARMCREDPNYYSYLEMDLQCRDPDIHAAAFGTCLAASVAAPGSGRVLYAVFSRDSRSSGGPGAGLCLFPLDKVHAKMEANRNACYTGTREARDIFYKPFHGDIQCGGHAPGSSKSFPCGSEHLPYPLGSRDGLRGTAVLQRGGLNLTAVTVAAENNHTVAFLGTSDGRILKVYLTPDGTSSEYDSILVEINKRVKRDLVLSGDLGSLYAMTQDKVFRLPVQECLSYPTCTQCRDSQDPYCGWCVVEGRCTRKAECPRAEEASHWLWSRSKSCVAVTSAQPQNMSRRAQGEVQLTVSPLPALSEEDELLCLFGESPPHPARVEGEAVICNSPSSIPVTPPGQDHVAVTIQLLLRRGNIFLTSYQYPFYDCRQAMSLEENLPCISCVSNRWTCQWDLRYHECREASPNPEDGIVRAHMEDSCPQFLGPSPLVIPMNHETDVNFQGKNLDTVKGSSLHVGSDLLKFMEPVTMQESGTFAFRTPKLSHDANETLPLHLYVKSYGKNIDSKLHVTLYNCSFGRSDCSLCRAANPDYRCAWCGGQSRCVYEALCNTTSECPPPVITRIQPETGPLGGGIRITILGSNLGVQAGDIQRISVAGRNCSFQPERYSVSTRIVCVIEAAETPFTGGVEVDVFGKLGRSPPNVQFTFQQPKPLSVEPQQGPQAGGTTLTIHGTHLDTGSQEDVRVTLNGVPCKVTKFGAQLQCVTGPQATRGQMLLEVSYGGSPVPNPGIFFTYRENPVLRAFEPLRSFASGGRSINVTGQGFSLIQRFAMVVIAEPLQSWQPPREAESLQPMTVVGTDYVFHNDTKVVFLSPAVPEEPEAYNLTVLIEMDGHRALLRTEAGAFEYVPDPTFENFTGGVKKQVNKLIHARGTNLNKAMTLQEAEAFVGAERCTMKTLTETDLYCEPPEVQPPPKRRQKRDTTHNLPEFIVKFGSREWVLGRVEYDTRVSDVPLSLILPLVIVPMVVVIAVSVYCYWRKSQQAEREYEKIKSQLEGLEESVRDRCKKEFTDLMIEMEDQTNDVHEAGIPVLDYKTYTDRVFFLPSKDGDKDVMITGKLDIPEPRRPVVEQALYQFSNLLNSKSFLINFIHTLENQREFSARAKVYFASLLTVALHGKLEYYTDIMHTLFLELLEQYVVAKNPKLMLRRSETVVERMLSNWMSICLYQYLKDSAGEPLYKLFKAIKHQVEKGPVDAVQKKAKYTLNDTGLLGDDVEYAPLTVSVIVQDEGVDAIPVKVLNCDTISQVKEKIIDQVYRGQPCSCWPRPDSVVLEWRPGSTAQILSDLDLTSQREGRWKRVNTLMHYNVRDGATLILSKVGVSQQPEDSQQDLPGERHALLEEENRVWHLVRPTDEVDEGKSKRGSVKEKERTKAITEIYLTRLLSVKGTLQQFVDNFFQSVLAPGHAVPPAVKYFFDFLDEQAEKHNIQDEDTIHIWKTNSLPLRFWVNILKNPHFIFDVHVHEVVDASLSVIAQTFMDACTRTEHKLSRDSPSNKLLYAKEISTYKKMVEDYYKGIRQMVQVSDQDMNTHLAEISRAHTDSLNTLVALHQLYQYTQKYYDEIINALEEDPAAQKMQLAFRLQQIAAALENKVTDL
uniprot
proteins
function
FUNCTION: Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling (By similarity). Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development (By similarity). Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248' (By similarity). Also acts as a cell surface receptor for angiogenin (ANG); promoting ANG endocytosis and translocation to the cytoplasm or nucleus (PubMed:29100074, PubMed:32510170). Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development (By similarity). Regulates the migration of cerebellar granule cells in the developing brain (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12183458). Plays a role in axon guidance, invasive growth and cell migration (PubMed:15184888). May modulate the activity of RAC1 and CDC42 (By similarity). {ECO:0000250|UniProtKB:B2RXS4, ECO:0000269|PubMed:12183458, ECO:0000269|PubMed:15184888, ECO:0000269|PubMed:29100074, ECO:0000269|PubMed:32510170}.
uniprot
proteins
mass_dalton
205127
uniprot
proteins
mutagenesis
MUTAGEN 1161..1164; /note="RQKR->AQKA: Abolishes cleavage by proprotein convertases."; /evidence="ECO:0000269|PubMed:12533544
uniprot
proteins
protein_family
Plexin family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
12183458
uniprot
proteins
pubmed
12533544
uniprot
proteins
pubmed
15184888
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29100074
uniprot
proteins
pubmed
32510170
uniprot
proteins
pubmed
34114565
uniprot
proteins
pubmed
9205841
uniprot
proteins
sequence_length
1838
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12533544}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 1198..1218; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins