Fscn2
entrez
238021
canonical
uniprot
Q32M02
canonical
ensembl
ENSMUSG00000025380
resolver
ensp
ENSMUSP00000026445
resolver
enst
ENSMUST00000026445
resolver
genesymbol
Fscn2
resolver
uniprot
Q8BWU0
resolver
uniprot_entry
FSCN2_MOUSE
resolver
uniprot_sec
Q8BWU0
resolver
amino_acid_sequence
MPTNGLHQVLKIQFGLVNDADRYLTAESFGFKVNASAASLKRKQIWVLEPDPGQGTAVLFRSSHLGRYLSAEEDGRVACEMDQPGRDCRFLVLPQPDGRWVLQSEPHGRFFGGIEDRLSCFATAISPAELWTVHLAIHPQAHLLSVSRRRYVHLCLQEDEMAADGDMPWGVDALVTLIFQSRRYCLKSYDSRYLRSDGRLVWEPEAHACYTLEFKAGKLAFKDCDGRYLAPVGPAGTLKAGRNTRPSKDELFDLEQSHPQVVLVAANRRYISVRQGINVSANQDEELGHETFLMQIDQETKKCTFYSSTGGYWTLVTHGGIQATATQVSANTMFEIEWHGRRVALKASNGRFVCMKKNGQLAAISDFVGEDELFTLKLINRPLLVLRGLDGFVCHRRGSNQLDTNRSTYDVFHLSFRDGAYQIRGRGGGFWYTGSHGSVCSDGDLAEDFLFEFRERGRLAIRALSGKYLRGGASGLLRADADLPVGEALWEY
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Fscn2 lead to hair-cell degeneration in the inner ear and are a key contributor to the early-onset, age-related hearing loss (prebycusis) phenotype when in combination with waltzer cadherin 23 mutant. {ECO:0000269|PubMed:20660251}.
uniprot
proteins
function
FUNCTION: Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis. Important for maintaining functional hair-cell bundles in the inner ear. May stiffen the longer stereocilia of hair-cell bundles in the inner ear enabling better force transmission to tip links. {ECO:0000269|PubMed:20660251}.
uniprot
proteins
mass_dalton
55073
uniprot
proteins
protein_family
Fascin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20660251
uniprot
proteins
pubmed
27811163
uniprot
proteins
sequence_length
492
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20660251}. Cell projection, stereocilium {ECO:0000269|PubMed:20660251, ECO:0000269|PubMed:27811163}. Note=Found mostly in longer hair-cell stereocilia and, in all stereocilia, present in gradient with the highest concentration at stereocilia tips.
uniprot
proteins