MEPCE
entrez
56257
canonical
uniprot
Q7L2J0
canonical
ensembl
ENSG00000146834
resolver
ensembl
ENSG00000289690
resolver
ensp
ENSP00000308546
resolver
ensp
ENSP00000400875
resolver
ensp
ENSP00000511703
resolver
ensp
ENSP00000511704
resolver
genesymbol
MEPCE
resolver
genesymbol_syn
BCDIN3
resolver
hgnc
HGNC:20247
resolver
uniprot
B3KP86
resolver
uniprot
D6W5V7
resolver
uniprot
Q9NPD4
resolver
uniprot_entry
MEPCE_HUMAN
resolver
uniprot_sec
B3KP86
resolver
uniprot_sec
D6W5V7
resolver
uniprot_sec
Q9NPD4
resolver
amino_acid_sequence
MIEMAAEKEPFLVPAPPPPLKDESGGGGGPTVPPHQEAASGELRGGTERGPGRCAPSAGSPAAAVGRESPGAAATSSSGPQAQQHRGGGPQAQSHGEARLSDPPGRAAPPDVGEERRGGGGTELGPPAPPRPRNGYQPHRPPGGGGGKRRNSCNVGGGGGGFKHPAFKRRRRVNSDCDSVLPSNFLLGGNIFDPLNLNSLLDEEVSRTLNAETPKSSPLPAKGRDPVEILIPKDITDPLSLNTCTDEGHVVLASPLKTGRKRHRHRGQHHQQQQAAGGSESHPVPPTAPLTPLLHGEGASQQPRHRGQNRDAPQPYELNTAINCRDEVVSPLPSALQGPSGSLSAPPAASVISAPPSSSSRHRKRRRTSSKSEAGARGGGQGSKEKGRGSWGGRHHHHHPLPAAGFKKQQRKFQYGNYCKYYGYRNPSCEDGRLRVLKPEWFRGRDVLDLGCNVGHLTLSIACKWGPSRMVGLDIDSRLIHSARQNIRHYLSEELRLPPQTLEGDPGAEGEEGTTTVRKRSCFPASLTASRGPIAAPQVPLDGADTSVFPNNVVFVTGNYVLDRDDLVEAQTPEYDVVLCLSLTKWVHLNWGDEGLKRMFRRIYRHLRPGGILVLEPQPWSSYGKRKTLTETIYKNYYRIQLKPEQFSSYLTSPDVGFSSYELVATPHNTSKGFQRPVYLFHKARSPSH
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that adds a methylphosphate cap at the 5'-end of 7SK snRNA (7SK RNA), leading to stabilize it (PubMed:17643375, PubMed:19906723, PubMed:30559425). Also has a non-enzymatic function as part of the 7SK RNP complex: the 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:17643375). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (PubMed:28254838). In the 7SK RNP complex, MEPCE is required to stabilize 7SK RNA and facilitate the assembly of 7SK RNP complex (PubMed:19906723, PubMed:38100593). MEPCE has a non-enzymatic function in the 7SK RNP complex; interaction with LARP7 within the 7SK RNP complex occluding its catalytic center (PubMed:19906723). Also required for stability of U6 snRNAs (PubMed:38100593). {ECO:0000269|PubMed:17643375, ECO:0000269|PubMed:19906723, ECO:0000269|PubMed:28254838, ECO:0000269|PubMed:30559425, ECO:0000269|PubMed:38100593}.
uniprot
proteins
mass_dalton
74355
uniprot
proteins
mutagenesis
MUTAGEN 152; /note="S->A: Promotes RNA polymerase II transcription pause-release."; /evidence="ECO:0000269|PubMed:39603240"; MUTAGEN 421; /note="Y->A: Nearly abolished methyltransferase activity."; /evidence="ECO:0000269|PubMed:30559425"; MUTAGEN 447..449; /note="VLD->AAA: Abolished methyltransferase activity and reduced interaction with LARP7, without affecting interaction with P-TEFb."; /evidence="ECO:0000269|PubMed:19906723"; MUTAGEN 585; /note="K->A: Decreased methyltransferase activity."; /evidence="ECO:0000269|PubMed:30559425"; MUTAGEN 674; /note="F->A: Strongly reduced methyltransferase activity."; /evidence="ECO:0000269|PubMed:30559425
uniprot
proteins
post_translational_modification
PTM: Dephosphorylated at Ser-152 by the PNUTS-PP1 complex, promoting RNA polymerase II transcription pause-release. {ECO:0000269|PubMed:39603240}.
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
pubmed
12358911
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17643375
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19906723
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28254838
uniprot
proteins
pubmed
29051200
uniprot
proteins
pubmed
30559425
uniprot
proteins
pubmed
30824372
uniprot
proteins
pubmed
38100593
uniprot
proteins
pubmed
39603240
uniprot
proteins
sequence_length
689
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19906723}.
uniprot
proteins