P0C6B8
uniprot
P0C6B8
canonical
amino_acid_sequence
MWTRLAFCCWALALVSGWTNFQPMAPSLNFSFRLFPEASPGALGRLAVPPRSGEEEAVGSKVERLGRTFRSRVRRLRELSDRLELVFLVDESSSVGQTNFLNELKFVRKLLSDFPVVSTATRVAIVTFSSKNNVVARVDYISTSRAHQHKCALLSREIPAITYRGGGTYTMGAFQQAAQILRHSRENSTKVIFLITDGYSNGGDPRPIAASLRDFGVEIFTFGIWQGNIRELNDMASTPKEEHCYLLHSFEEFEALARRALHEDLPSGSFIQEDMAHCSYLCEAGRDCCDRMASCKCGTHTGQFECICEKGYYGKGLQYECTACPPGTYKPEASPGGISTCIPCPDENHTSPPGSTAPEDCVCREGYQRSGQTCEVVHCPALKPPENGFFIQNTCKNHFNAACGVRCRPGFDLVGSSIHLCQPNGLWSGTESFCRVRTCPHLRQPKHGHISCSTVEMSYNTVCLVTCNEGYRLEGHAKLTCQGNAQWDGTEPRCVERHCATFQKPKGVIISPPSCGKQPAKPGMICQLGCRQGYILSGIREVRCATSGKWSARVQTAVCKDVEAPQISCPNDIKAKTEGQQDSANVTWQVPTAKDNSGEKVSVHVHPAFSPPYLFPIGEVAITYTATDSSGNQASCTFYIKVIDVEPPVIDWCRSPPPIQVVEKEHPASWDEPQFSDNSGAELVITSSHTQGDLFPHGETVVWYTATDPSGNNRTCDIHIVIKGSPCEVPFTPVNGDFICAQDSAGVNCSLTCREGYDFTEGSTEKYYCAFEDGIWRPPYSTEWPDCAIKRFANHGFKSFEMLYKTTRCDDMDLFKKFSAAFETTLGKMVPSFCSDADDIDCRLEDLTKKYCIEYNYNYENGFAIGPGGWGAGNRLDYSYDHFLDVVQETPADVGKTRSSRIKRTVPLSDPQIQLIFNITASVPLPEERNDTVELENQQRLIRTLETITNRLKSTLNKGPMYSFQLASETVVADSNSLETEKAFLFCRPGSVLRGRMCVNCPLGTSYSLEHSTCESCLMGSYQDEEGQLECKLCPPRTHTEYLHSRSISECKAQCKQGTYSSSGLETCESCPLGTYQPDFGSRSCLPCPETTTTVKRGAVDISACGVPCPVGEFSRSGLTPCYPCPRDYYQPNAGKSFCLACPFYGTTTITGATSITDCSSFSSTFSAAEESIVPLAAPGPTQNKYEVFHECFLNPCHNSGTCQQLGRGYVCLCPPGYTGLKCETDIDECSSLPCLNGGICRDKVGGFTCECSSGYTGQICEENINECSSSPCLNKGTCTDGLASYRCTCVSGYVGVHCETDVNECQSSPCLNNAVCKDQVGGFSCKCPPGFLGTRCEKNVDECLSQPCQNGATCKDGANSFRCQCPAGFTGPHCELNINECQSNPCRNQATCVDELNSYSCKCRPGFSGRRCETEQPSGFNLDFEVSGIYGYVLLDGVLPTLHAITCAFWMKSSDVINYGTPISYALEGNKDNTFLLTDYNGWVLYVNGKEKITNCPSVNDGIWHHIAITWTSTGGAWRVYIDGELSDSGTGLSVGKAIPGGGALVLGQEQDKKGEGFNPAESFVGSISQLNLWDYVLSPQQVKSLASSCPEELSRGNVLAWPDFVSGITGKVKVDSSSIFCSDCPSLEGSVPHLRPASGDRKPGSKVSLFCDPGFQMVGNPVQYCLNQGQWSQPLPHCERIRCGLPPTLENGFYSAEDLHAGSTVTYQCTSGYYLLGDSRMFCTDNGSWNGISPSCLDVDECAVGSDCSEHASCLNTNGSYICSCKPPYTGDGKNCAEPVKCKAPENPENGHSLGKIYSVGAEVTFSCEEGHQLVGVRKITCLESGEWDHLRPSCEAISCGAPPVPENGGVDGSAFTYGSKVRYRCDKGYTLAGDEESACLASGSWSHSSPVCELVKCSQPENINNGKYILSGLTYLSIASYSCEDGYSLQGPSLIECTASGSWDRAPPSCQLVSCGEPPMVKDALTTGSNFTFGNMVTYTCKEGYTLAGPDTIICQANGKWNSSNHQCLAVSCDEPPNVDHASPETAHRLFGDTAFYYCADGYSLADNSQLICNAQGNWVPPEGQAVPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECLRGGQWSPSPLSVQCIPVRCGEPPSITNGYPSGTNYSFGAVVAYSCHKGFYIKGEKKSTCEATGQWSRPLPTCHPVSCNEPPKVENGFLEHTTGRTFESEARFQCNPGYKAVGSPVFVCQANRHWHSDAPLSCTPLNCGKPPPIQNGFLRGESFEVGSKVQFVCNEGYELVGDNSWTCQKSGKWSKKPSPKCVPTKCAEPPLLENQLVLKELTSEVGVMTISCKEGHALQGPSVLKCLPSGQWNGSFPVCKLVLCQSPPLIPFGVPASSGALHFGSTVKYLCVDGFFLRGNPIILCQVDGTWSSPLPECVPVECPQPEEILNGIIHVQGLAYLSTTLYTCKPGFELVGNTTTLCGENGQWLGGKPMCRPIECPEPKEILNGQFSSVSFQYGQTITYSCDRGFRLEGPKSLTCLETGNWDMDAPSCNAIHCSDPQPIENGFVEGADYRYGAMIIYSCFPGFQVVGHAMQTCEETGWSSSSPTCVPIDCGLPPHIDFGDCTRVSDGQGYFVQEDDMMEVPYLTPHPQHLEATAKASEITEESLVPHASQFLYGTTVSYRCEPGYELLGIPVLVCQEDGTWNGTAPSCISIECDLPVAPENGFLHFTQTTMGSAAQYSCKPGHVLEGSHLRLCLQNKQWSGTVPRCEVISCSEPNPLGNGSIKGNDYSYLGVLHYECDSGYVLNGTEKRTCQENKQWDGHEPVCLPVDCGSPPVPTNGQVTGEEYTFQKEIAYSCGEGFILEGARSRVCLTNGSWSGTTPSCVPVRCPAPPQVANGVTDGLDYGFKKEVTFHCLEGYVLQGTPKLTCQSNGTWDAEVPICKPATCGPPADLPQGFPNGFSFFHGGHIQYQCFTGYKLHGNPSRRCLPDGSWSGSTPSCLPCTCSTPIIQQGTVNATDLGCGKTVQIECFKGFKLLGLPEITCDANGQWSDFPLCEHADCGPLPTVPNGIVIKGSPSEDNVVTYSCRPGYIIQGSSDLICTEKGIWSEPYPTCEPVSCGPPPTVANAVATGEAHTYESKVKLRCLEGYVVDTDTDTFTCQQDGRWFPERINCSPKTCPVPSNRTRIRVHGDDFQVNRQVSVSCTEGFTYDGADRSTCQPDGTWEPPLSEESCIPVVCGQPESPEHGFVVGSEYSFGSTVVYQCDPGYELEGNRERVCQENRQWSGRVAVCRESRCEAPAEFPNGKAVLENTTSGPSLLFSCHRGYTLEGPPEAHCTANGTWSHLAPLCKPNPCPVPFVIPENALLSEREFYVNQNVSIKCREGFLLKGNGIITCNPDETWTQTNARCEKISCGPPTHVENAIARGVHYQYGDMVTFSCYSGYMLEGSLRSVCLENGTWTPPPICRAVCRFPCQNGGVCQRPNACSCPDGWMGRLCEEPICILPCLNGGRCVAPYRCDCPAGWTGSRCHTATCQSPCLNGGKCVRPNRCHCLSSWTGHDCSRKRRSGL
uniprot
proteins
function
FUNCTION: Required for morphological development, cell alignment and migration of lymphatic endothelial cells during embryonic development, potentially via modulation of ANGPT2-TIE1 signaling and subsequent activation of FOXC2 transcription (By similarity). Required for embryonic lymphatic vascular development, via mediating the correct formation of the first lymphovenous contact site and tight association of the lymphatic endothelium with the venous endothelium (By similarity). Represses PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells, via its interaction with integrins, thereby inhibiting vasocontraction (By similarity). Promotes platelet activation, via its interaction with PEAR1 and subsequent activation of AKT/mTOR signaling (By similarity). Plays a role in epidermal development and keratinocyte differentiation, independent of cell-cell adhesion (By similarity). May play a role in initial cell attachment of stromal osteogenic cells (By similarity). May promote myoblast cell adhesion when in the presence of integrin ITGA9:ITGB1 (By similarity). {ECO:0000250|UniProtKB:A2AVA0, ECO:0000250|UniProtKB:Q4LDE5}.
uniprot
proteins
mass_dalton
387355
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
17139625
uniprot
proteins
sequence_length
3564
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:A2AVA0}. Nucleus {ECO:0000250|UniProtKB:Q4LDE5}. Cytoplasm {ECO:0000250|UniProtKB:Q4LDE5}. Membrane {ECO:0000250|UniProtKB:Q4LDE5}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q4LDE5}.
uniprot
proteins