Mknk2
entrez
17347
canonical
uniprot
Q8CDB0
canonical
ensembl
ENSMUSG00000020190
resolver
ensp
ENSMUSP00000003433
resolver
ensp
ENSMUSP00000143508
resolver
ensp
ENSMUSP00000263106
resolver
enst
ENSMUST00000003433
resolver
genesymbol
Mknk2
resolver
genesymbol_syn
Mnk2
resolver
uniprot
A0A0R4IZX7
resolver
uniprot
O08606
resolver
uniprot
Q3TPM2
resolver
uniprot
Q75PY0
resolver
uniprot
Q9D893
resolver
uniprot_entry
A0A0R4IZX7_MOUSE
resolver
uniprot_entry
MKNK2_MOUSE
resolver
uniprot_entry
Q3TPM2_MOUSE
resolver
uniprot_sec
O08606
resolver
uniprot_sec
Q75PY0
resolver
uniprot_sec
Q9D893
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by CGP57380 and staurosporine. {ECO:0000269|PubMed:17903173, ECO:0000269|PubMed:20927323}.
uniprot
proteins
amino_acid_sequence
MVQKRTAELQGFHRSFKGQNPFELAFSLDLAQHRDSDFSPQCEARPDMPSSQPIDIPDAKKRGRKKKRCRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCVNLITNQEYAVKIIEKQLGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHRRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGHCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWSHISFAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTLPTPLVLQRNSCAKDLTSFAAEAIAMNRQLAQCEEDAGQDQPVVIRATSRCLQLSPPSQSKLAQRRQRASLSATPVVLVGDRA
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Enhances the formation of EIF4F complex in pachytene spermatocytes, thus promoting mRNA translation during spermatogenesis. Displays a high basal kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal. {ECO:0000269|PubMed:11154262, ECO:0000269|PubMed:17689282, ECO:0000269|PubMed:17903173, ECO:0000269|PubMed:20574055, ECO:0000269|PubMed:20823271, ECO:0000269|PubMed:20927323, ECO:0000269|PubMed:9155017}.
uniprot
proteins
mass_dalton
51633
uniprot
proteins
mutagenesis
MUTAGEN 238; /note="D->A: Loss of activity."; /evidence="ECO:0000269|PubMed:16162500"; MUTAGEN 438; /note="L->A: Reduced phosphorylation."; /evidence="ECO:0000269|PubMed:16162500"; MUTAGEN 440; /note="Q->R: Reduced MAPK3/ERK1 and MAPK1/ERK2-binding."; /evidence="ECO:0000269|PubMed:16162500"; MUTAGEN 446; /note="S->A,D: Normal MAPK3/ERK1 and MAPK1/ERK2-binding."; /evidence="ECO:0000269|PubMed:16162500"; MUTAGEN 448; /note="S->A: Normal MAPK3/ERK1 and MAPK1/ER2K-binding."; /evidence="ECO:0000269|PubMed:16162500"; MUTAGEN 448; /note="S->D: Reduced MAPK3/ERK1 and MAPK1/ER2K-binding."; /evidence="ECO:0000269|PubMed:16162500
uniprot
proteins
post_translational_modification
PTM: Dual phosphorylation of Thr-244 and Thr-249 activates the kinase. Phosphorylation of Thr-379 activates the kinase. Phosphorylated upon arsenic trioxide As(2)O(3) treatment. Phosphorylated by MAPK1/ERK2, MAPK11 and MAPK14 (By similarity). Dephosphorylated by PP2A. {ECO:0000250, ECO:0000269|PubMed:11154262}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11154262
uniprot
proteins
pubmed
15254222
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16162500
uniprot
proteins
pubmed
17689282
uniprot
proteins
pubmed
17903173
uniprot
proteins
pubmed
20574055
uniprot
proteins
pubmed
20823271
uniprot
proteins
pubmed
20927323
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9155017
uniprot
proteins
sequence_length
459
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, PML body {ECO:0000250}.
uniprot
proteins