EEF2K
entrez
29904
canonical
uniprot
O00418
canonical
ensembl
ENSG00000103319
resolver
ensembl
ENSG00000284161
resolver
ensp
ENSP00000263026
resolver
ensp
ENSP00000492375
resolver
ensp
ENSP00000494400
resolver
ensp
ENSP00000604489
resolver
ensp
ENSP00000612118
resolver
ensp
ENSP00000612119
resolver
ensp
ENSP00000612121
resolver
enst
ENST00000263026
resolver
enst
ENST00000638831
resolver
enst
ENST00000644765
resolver
enst
ENST00000934430
resolver
enst
ENST00000942059
resolver
enst
ENST00000942060
resolver
enst
ENST00000942062
resolver
genesymbol
EEF2K
resolver
hgnc
HGNC:24615
resolver
uniprot
A0AAG2TFE4
resolver
uniprot
Q8N588
resolver
uniprot_entry
A0AAG2TFE4_HUMAN
resolver
uniprot_entry
EF2K_HUMAN
resolver
uniprot_sec
Q8N588
resolver
activity_regulation
ACTIVITY REGULATION: Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent. {ECO:0000250|UniProtKB:P70531}.
uniprot
proteins
amino_acid_sequence
MADEDLIFRLEGVDGGQSPRAGHDGDSDGDSDDEEGYFICPITDDPSSNQNVNSKVNKYYSNLTKSERYSSSGSPANSFHFKEAWKHAIQKAKHMPDPWAEFHLEDIATERATRHRYNAVTGEWLDDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDRDVYFEDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKDRPGKPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHTETGTDFGDGNLGVRGMALFFYSHACNRICESMGLAPFDLSPRERDAVNQNTKLLQSAKTILRGTEEKCGSPQVRTLSGSRPPLLRPLSENSGDENMSDVTFDSLPSSPSSATPHSQKLDHLHWPVFSDLDNMASRDHDHLDNHRESENSGDSGYPSEKRGELDDPEPREHGHSYSNRKYESDEDSLGSSGRVCVEKWNLLNSSRLHLPRASAVALEVQRLNALDLEKKIGKSILGKVHLAMVRYHEGGRFCEKGEEWDQESAVFHLEHAANLGELEAIVGLGLMYSQLPHHILADVSLKETEENKTKGFDYLLKAAEAGDRQSMILVARAFDSGQNLSPDRCQDWLEALHWYNTALEMTDCDEGGEYDGMQDEPRYMMLAREAEMLFTGGYGLEKDPQRSGDLYTQAAEAAMEAMKGRLANQYYQKAEEAWAQMEE
uniprot
proteins
ec_number
2.7.11.20
uniprot
proteins
function
FUNCTION: Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced. {ECO:0000269|PubMed:14709557, ECO:0000269|PubMed:9144159}.
uniprot
proteins
mass_dalton
82144
uniprot
proteins
mutagenesis
MUTAGEN 78; /note="S->A: Decreased kinase activity."; /evidence="ECO:0000269|PubMed:22216903"; MUTAGEN 348; /note="T->A: Decreased kinase activity."; /evidence="ECO:0000269|PubMed:22216903"; MUTAGEN 366; /note="S->A: Abrogates phosphorylation by RPS6KB1."; /evidence="ECO:0000269|PubMed:11500364, ECO:0000269|PubMed:22216903"; MUTAGEN 366; /note="S->A: Decreased kinase activity."; /evidence="ECO:0000269|PubMed:11500364, ECO:0000269|PubMed:22216903
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated at multiple residues, Thr-348 being the major site. Phosphorylated by AMP-activated protein kinase AMPK at Ser-398 leading to EEF2K activation and protein synthesis inhibition. Phosphorylated by TRPM7 at Ser-78 resulting in improved protein stability, higher EE2F phosphorylated and subsequently reduced rate of protein synthesis. Phosphorylation by other kinases such as CDK1 and MAPK13 at Ser-359 or RPS6KA1 and RPS6KB1 at Ser-366 instead decrease EEF2K activity and promote protein synthesis. {ECO:0000269|PubMed:11015200, ECO:0000269|PubMed:11500363, ECO:0000269|PubMed:11500364, ECO:0000269|PubMed:14709557, ECO:0000269|PubMed:18337751, ECO:0000269|PubMed:21112387, ECO:0000269|PubMed:22216903}.
uniprot
proteins
protein_family
Alpha-type protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11015200
uniprot
proteins
pubmed
11500363
uniprot
proteins
pubmed
11500364
uniprot
proteins
pubmed
14709557
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18337751
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21112387
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22216903
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9144159
uniprot
proteins
sequence_length
725
uniprot
proteins