Kcnh2
entrez
16511
canonical
uniprot
O35219
canonical
ensembl
ENSMUSG00000038319
resolver
ensp
ENSMUSP00000047705
resolver
ensp
ENSMUSP00000110750
resolver
enst
ENSMUST00000036092
resolver
enst
ENSMUST00000115098
resolver
genesymbol
Kcnh2
resolver
genesymbol_syn
Erg
resolver
genesymbol_syn
Merg1
resolver
uniprot
A0A0R4J1K0
resolver
uniprot
F6YEA1
resolver
uniprot
O35220
resolver
uniprot
O35221
resolver
uniprot
O35989
resolver
uniprot
Q53Z09
resolver
uniprot_entry
A0A0R4J1K0_MOUSE
resolver
uniprot_entry
F6YEA1_MOUSE
resolver
uniprot_entry
KCNH2_MOUSE
resolver
uniprot_entry
Q53Z09_MOUSE
resolver
uniprot_sec
O35220
resolver
uniprot_sec
O35221
resolver
uniprot_sec
O35989
resolver
amino_acid_sequence
MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVIMFILNFEVVMEKDMVGSPAHDTNHRGPSTSWLASGRAKTFRLKLPALLALTARESSVRTGSMHSAGAPGAVVVDVDLTPAAPSSESLALDEVSAMDNHVAGLGPAEERRALVGPGSASPVASIRGPHPSPRAQSLNPDASGSSCSLARTRSRESCASVRRASSADDIEAMRAGALPPPPRHASTGAMHPLRSGLLNSTSDSDLVRYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAPKIKERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEDGSQAPDCGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSHIGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDTNMIPGSPGSAELESGFNRQRKRKLSFRRRTDKDTEQPGEVSALGQGPARVGPGPSCRGQPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGDPPGGEPLTEDGEKSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPAPSLLNIPLSSPGRRSRGDVESRLDALQRQLNRLETRLSADMATVLQLLQRQMTLVPPAYSAVTTPGPGPTSASPLLPVGPVPTLTLDSLSQVSQFVAFEELPAGAPELPQDGPTRRLSLPGQLGALTSQPLHRHGSDPGS
uniprot
proteins
function
FUNCTION: Pore-forming (alpha) subunit of voltage-gated inwardly rectifying potassium channel (PubMed:9351446, PubMed:9351462). Characterized by unusual gating kinetics by producing relatively small outward currents during membrane depolarization and large inward currents during subsequent repolarization which reflect a rapid inactivation during depolarization and quick recovery from inactivation but slow deactivation (closing) during repolarization. Channel properties are modulated by cAMP and subunit assembly (PubMed:9351446, PubMed:9351462). Forms a stable complex with KCNE1 or KCNE2, and that this heteromultimerization regulates inward rectifier potassium channel activity (By similarity). {ECO:0000250|UniProtKB:Q12809, ECO:0000269|PubMed:9351446, ECO:0000269|PubMed:9351462}.
uniprot
proteins
mass_dalton
126886
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine and threonine residues. Phosphorylation by PKA inhibits ion conduction. {ECO:0000250|UniProtKB:Q12809}.
uniprot
proteins
protein_family
H (Eag) (TC 1.A.1.20) subfamily
uniprot
proteins
protein_family
Kv11.1/KCNH2 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
9351446
uniprot
proteins
pubmed
9351462
uniprot
proteins
sequence_length
1162
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q12809}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 406..426; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 453..473; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 498..518; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 523..543; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 550..570; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 641..661; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins