PTAR1
entrez
375743
canonical
uniprot
Q7Z6K3
canonical
ensembl
ENSG00000188647
resolver
ensp
ENSP00000344299
resolver
ensp
ENSP00000366405
resolver
ensp
ENSP00000583010
resolver
ensp
ENSP00000666781
resolver
ensp
ENSP00000666782
resolver
ensp
ENSP00000666783
resolver
ensp
ENSP00000738809
resolver
enst
ENST00000340434
resolver
enst
ENST00000377200
resolver
genesymbol
PTAR1
resolver
hgnc
HGNC:30449
resolver
uniprot
Q5T7V5
resolver
uniprot
Q5T7V6
resolver
uniprot
X6R9N0
resolver
uniprot_entry
PTAR1_HUMAN
resolver
uniprot_entry
X6R9N0_HUMAN
resolver
uniprot_sec
Q5T7V5
resolver
uniprot_sec
Q5T7V6
resolver
amino_acid_sequence
MAETSEEVAVLVQRVVKDITNAFRRNPHIDEIGLIPCPEARYNRSPIVLVENKLGVESWCVKFLLPYVHNKLLLYRTRKQWLNRDELIDVTCTLLLLNPDFTTAWNVRKELILSGTLNPIKDLHLGKLALTKFPKSPETWIHRRWVLQQLIQETSLPSFVTKGNLGTIPTERAQRLIQEEMEVCGEAAGRYPSNYNAWSHRIWVLQHLAKLDVKILLDELSSTKHWASMHVSDHSGFHYRQFLLKSLISQTVIDSSVMEQNPLRSEPALVPPKDEEAAVSTEEPRINLPHLLEEEVEFSTDLIDSYPGHETLWCHRRHIFYLQHHLNAGSQLSQAMEVDGLNDSSKQGYSQETKRLKRTPVPDSLGLEMEHRFIDQVLSTCRNVEQARFASAYRKWLVTLSQ
uniprot
proteins
function
FUNCTION: Substrate-recognition subunit of the geranylgeranyl transferase type 3 (GGTase-3) complex (PubMed:31209342, PubMed:32128853). The GGTase-3 complex geranylgeranylates and targets FBXL2 to the cellular membranes, where FBXL2 forms part of the E3 ubiquitin-protein ligase complex SCF(FBXL2) that mediates the degradation of membrane-anchored proteins (PubMed:31209342, PubMed:32128853). The GGTase-3 complex geranylgeranylates Golgi v-SNARE protein YKT6 at 'Cys-194' and this prenylation is required for Golgi SNARE complex assembly (PubMed:32128853). {ECO:0000269|PubMed:31209342, ECO:0000269|PubMed:32128853}.
uniprot
proteins
mass_dalton
46405
uniprot
proteins
mutagenesis
MUTAGEN 31; /note="E->A: Impairs geranylgeranylation of YKT6."; /evidence="ECO:0000269|PubMed:32128853"; MUTAGEN 35; /note="I->A: Impairs geranylgeranylation of YKT6. Abolishes geranylgeranylation of YKT6; when associated with A-306."; /evidence="ECO:0000269|PubMed:32128853"; MUTAGEN 48; /note="V->A: Impairs geranylgeranylation of YKT6. Abolishes geranylgeranylation of YKT6; when associated with A-50 and A-306."; /evidence="ECO:0000269|PubMed:32128853"; MUTAGEN 50; /note="V->A: Impairs geranylgeranylation of YKT6. Abolishes geranylgeranylation of YKT6; when associated with A-48 and A-306."; /evidence="ECO:0000269|PubMed:32128853"; MUTAGEN 232; /note="S->A: Impairs geranylgeranylation of YKT6."; /evidence="ECO:0000269|PubMed:32128853"; MUTAGEN 306; /note="Y->A: Impairs geranylgeranylation of YKT6. Abolishes geranylgeranylation of YKT6; when associated with A-35. Abolishes geranylgeranylation of YKT6; when associated with A-48 and A-50."; /evidence="ECO:0000269|PubMed:32128853
uniprot
proteins
protein_family
Protein prenyltransferase subunit alpha family
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
31209342
uniprot
proteins
pubmed
32128853
uniprot
proteins
sequence_length
402
uniprot
proteins