P26824
uniprot
P26824
canonical
amino_acid_sequence
MGPRRLLLVAVGLSLCGPLLSSRVPMRQPESERMYATPYATPNPRSFFLRNPSEDTFEQFPLGDEEEKNESIPLEGRAVYLNKSRFPPMPPPPFISEDASGYLTSPWLTLFIPSVYTFVFIVSLPLNILAIAVFVFRMKVKKPAVVYMLHLAMADVLFVSVLPFKISYYFSGTDWQFGSGMCRFATAACYCNMYASIMLMTVISIDRFLAVVYPIQSLSWRTLGRANFTCVVIWVMAIMGVVPLLLKEQTTQVPGLNITTCHDVLNETLLHGFYSYYFSAFSAIFFLVPLIISTVCYTSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIVCFGPTNVLLIVHYLLLSDSPGTETAYFAYLLCVCVTSVASCIDPLIYYYASSECQKHLYSILCCRESSDSNSCNSTGQLMPSKMDTCSSHLNNSIYKKLLA
uniprot
proteins
function
FUNCTION: High affinity receptor that binds the activated thrombin, leading to calcium release from intracellular stores (PubMed:15145074). The thrombin-activated receptor signaling pathway is mediated through PTX-insensitive G proteins, activation of phospholipase C resulting in the production of 1D-myo-inositol 1,4,5-trisphosphate (InsP3) which binds to InsP3 receptors causing calcium release from the stores (PubMed:15145074). In astrocytes, the calcium released into the cytosol allows the Ca(2+)-dependent release of L-glutamate into the synaptic cleft through BEST1, that targets the neuronal postsynaptic GRIN2A/NMDAR receptor resulting in the synaptic plasticity regulation (By similarity). May play a role in platelets activation and in vascular development (By similarity). Mediates up-regulation of pro-inflammatory cytokines, such as MCP-1/CCL2 and IL6, triggered by coagulation factor Xa (F10) in cardiac fibroblasts and umbilical vein endothelial cells (By similarity). {ECO:0000250|UniProtKB:P25116, ECO:0000250|UniProtKB:P30558, ECO:0000269|PubMed:15145074}.
uniprot
proteins
mass_dalton
48281
uniprot
proteins
post_translational_modification
PTM: Proteolytic cleavage by thrombin generates a new N-terminus that functions as a tethered ligand. Also proteolytically cleaved by cathepsin CTSG and GZMK. {ECO:0000250|UniProtKB:P25116}.; PTM: Phosphorylated in the C-terminal tail; probably mediating desensitization prior to the uncoupling and internalization of the receptor. {ECO:0000250}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
1324917
uniprot
proteins
pubmed
15145074
uniprot
proteins
sequence_length
432
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15145074}; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 110..135; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 145..164; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 184..205; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 226..246; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 276..295; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 319..341; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 358..381; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins