GSDMC
entrez
56169
canonical
uniprot
Q9BYG8
canonical
ensembl
ENSG00000147697
resolver
ensp
ENSP00000276708
resolver
enst
ENST00000276708
resolver
genesymbol
GSDMC
resolver
genesymbol_syn
MLZE
resolver
hgnc
HGNC:7151
resolver
uniprot
Q5XKF3
resolver
uniprot
Q6P494
resolver
uniprot_entry
GSDMC_HUMAN
resolver
uniprot_sec
Q5XKF3
resolver
uniprot_sec
Q6P494
resolver
activity_regulation
ACTIVITY REGULATION: [Gasdermin-C]: The full-length protein before cleavage is inactive: intramolecular interactions between N- and C-terminal domains mediate autoinhibition in the absence of activation signal (PubMed:32929201, PubMed:34012073). The intrinsic pyroptosis-inducing activity is carried by the released N-terminal moiety (Gasdermin-C, N-terminal) following cleavage by caspase CASP8 (PubMed:32929201, PubMed:34012073). {ECO:0000269|PubMed:32929201, ECO:0000269|PubMed:34012073}.
uniprot
proteins
amino_acid_sequence
MPSMLERISKNLVKEIGSKDLTPVKYLLSATKLRQFVILRKKKDSRSSFWEQSDYVPVEFSLNDILEPSSSVLETVVTGPFHFSDIMIQKHKADMGVNVGIEVSVSGEASVDHGCSLEFQIVTIPSPNLEDFQKRKLLDPEPSFLKECRRRGDNLYVVTEAVELINNTVLYDSSSVNILGKIALWITYGKGQGQGESLRVKKKALTLQKGMVMAYKRKQLVIKEKAILISDDDEQRTFQDEYEISEMVGYCAARSEGLLPSFHTISPTLFNASSNDMKLKPELFLTQQFLSGHLPKYEQVHILPVGRIEEPFWQNFKHLQEEVFQKIKTLAQLSKDVQDVMFYSILAMLRDRGALQDLMNMLELDSSGHLDGPGGAILKKLQQDSNHAWFNPKDPILYLLEAIMVLSDFQHDLLACSMEKRILLQQQELVRSILEPNFRYPWSIPFTLKPELLAPLQSEGLAITYGLLEECGLRMELDNPRSTWDVEAKMPLSALYGTLSLLQQLAEA
uniprot
proteins
function
FUNCTION: [Gasdermin-C]: This form constitutes the precursor of the pore-forming protein: upon cleavage, the released N-terminal moiety (Gasdermin-C, N-terminal) binds to membranes and forms pores, triggering pyroptosis. {ECO:0000269|PubMed:32929201, ECO:0000269|PubMed:34012073}.; FUNCTION: [Gasdermin-C, N-terminal]: Pore-forming protein that causes membrane permeabilization and pyroptosis (PubMed:27281216, PubMed:32929201, PubMed:34012073). Produced by the cleavage of gasdermin-C by caspase CASP8 in response to death signals (PubMed:32929201, PubMed:34012073). After cleavage, moves to the plasma membrane where it strongly binds to membrane inner leaflet lipids (PubMed:32929201, PubMed:34012073). Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis (PubMed:32929201, PubMed:34012073). {ECO:0000269|PubMed:27281216, ECO:0000269|PubMed:32929201, ECO:0000269|PubMed:34012073}.
uniprot
proteins
mass_dalton
57692
uniprot
proteins
mutagenesis
MUTAGEN 231..232; /note="DD->AA: Does not affect cleavage by CASP8 in response to alpha-ketoglutarate."; /evidence="ECO:0000269|PubMed:34012073"; MUTAGEN 233; /note="D->A: Does not affect cleavage by CASP8 in response to alpha-ketoglutarate."; /evidence="ECO:0000269|PubMed:34012073"; MUTAGEN 240; /note="D->A: Impaired cleavage by CASP8 in response to alpha-ketoglutarate."; /evidence="ECO:0000269|PubMed:34012073"; MUTAGEN 276; /note="D->A: Does not affect cleavage by CASP8 in response to alpha-ketoglutarate."; /evidence="ECO:0000269|PubMed:34012073"; MUTAGEN 319; /note="L->D: Low spontaneous pyroptosis-inducing activity."; /evidence="ECO:0000269|PubMed:27281216"; MUTAGEN 365; /note="D->A: Abolished cleavage by CASP8."; /evidence="ECO:0000269|PubMed:32929201"; MUTAGEN 398; /note="Y->D: Low spontaneous pyroptosis-inducing activity."; /evidence="ECO:0000269|PubMed:27281216"; MUTAGEN 402; /note="A->D: Spontaneous pyroptosis-inducing activity."; /evidence="ECO:0000269|PubMed:27281216
uniprot
proteins
post_translational_modification
PTM: Cleavage by CASP8 relieves autoinhibition by releasing the N-terminal moiety (Gasdermin-C, N-terminal) that initiates pyroptosis (PubMed:32929201, PubMed:34012073). The cleavage site is unclear (PubMed:32929201, PubMed:34012073). According to a publication, it takes place after Asp-240 in response to alpha-ketoglutarate (PubMed:34012073). Another paper reports cleavage by CASP8 after Asp-365 (PubMed:32929201). {ECO:0000269|PubMed:32929201, ECO:0000269|PubMed:34012073}.; PTM: Palmitoylated. {ECO:0000269|PubMed:38599239}.
uniprot
proteins
protein_family
Gasdermin family
uniprot
proteins
pubmed
11223543
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
17350798
uniprot
proteins
pubmed
19051310
uniprot
proteins
pubmed
27281216
uniprot
proteins
pubmed
32929201
uniprot
proteins
pubmed
34012073
uniprot
proteins
pubmed
38599239
uniprot
proteins
sequence_length
508
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Gasdermin-C]: Cytoplasm, cytosol {ECO:0000269|PubMed:11223543}.; SUBCELLULAR LOCATION: [Gasdermin-C, N-terminal]: Cell membrane {ECO:0000269|PubMed:32929201}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5Y4Y6}.
uniprot
proteins