Hes7
entrez
84653
canonical
uniprot
Q8BKT2
canonical
ensembl
ENSMUSG00000023781
resolver
ensp
ENSMUSP00000024543
resolver
enst
ENSMUST00000024543
resolver
genesymbol
Hes7
resolver
uniprot
A3KPD3
resolver
uniprot
Q99JA6
resolver
uniprot_entry
HES7_MOUSE
resolver
uniprot_sec
A3KPD3
resolver
uniprot_sec
Q99JA6
resolver
amino_acid_sequence
MVTRERAENRDGPKMLKPLVEKRRRDRINRSLEELRLLLLERTRDQNLRNPKLEKAEILEFAVGYLRERSRVEPPGVPRSPGQDAEALASCYLSGFRECLLRLAAFAHDASPAARSQLFSALHGYRRPKPPRPEAVDPGLPAPRPPLDPASPILGPALHQRPPVHQGPPSPRLAWSPSHCSSRAGDSGAPAPLTGLLPPPPPPYRQDGAPKAPSLPPPAFWRPWP
uniprot
proteins
function
FUNCTION: Transcriptional repressor. Represses transcription from both N box- and E box-containing promoters. May with HES1, cooperatively regulate somite formation in the presomitic mesoderm (PSM). May function as a segmentation clock, which is essential for coordinated somite segmentation. {ECO:0000269|PubMed:11260262, ECO:0000269|PubMed:15170214, ECO:0000269|PubMed:18775957}.
uniprot
proteins
mass_dalton
24890
uniprot
proteins
mutagenesis
MUTAGEN 14; /note="K->R: No loss of repressor activity, somite segmentation disrupted at later stages."; /evidence="ECO:0000269|PubMed:15170214"; MUTAGEN 17; /note="K->R: Loss of repressor activity."; /evidence="ECO:0000269|PubMed:15170214"; MUTAGEN 22; /note="K->R: Loss of repressor activity."; /evidence="ECO:0000269|PubMed:15170214"; MUTAGEN 25; /note="R->W: Loss of repressor activity."; /evidence="ECO:0000269|PubMed:18775957"; MUTAGEN 52; /note="K->R: Loss of repressor activity."; /evidence="ECO:0000269|PubMed:15170214"; MUTAGEN 55; /note="K->R: Loss of repressor activity."; /evidence="ECO:0000269|PubMed:15170214"; MUTAGEN 58; /note="I->V: No loss of repressor activity."; /evidence="ECO:0000269|PubMed:20087400"; MUTAGEN 129; /note="K->R: No loss of repressor activity."; /evidence="ECO:0000269|PubMed:15170214"; MUTAGEN 186; /note="D->Y: Partial loss of repressor activity."; /evidence="ECO:0000269|PubMed:20087400"; MUTAGEN 211; /note="K->R: No loss of repressor activity."; /evidence="ECO:0000269|PubMed:15170214
uniprot
proteins
pubmed
11260262
uniprot
proteins
pubmed
15170214
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18775957
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20087400
uniprot
proteins
sequence_length
225
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins