Q99N01
uniprot
Q99N01
canonical
amino_acid_sequence
MPQHAMGDKHFLSLPKHLFTSTSSTTDSGCDTPPSSRASPASLRSAHGALGSSSQPLFEPQVEKRSSQAACEVQYLSSGPQSTLCGWQSFTPKCLQVFNTPKGFLFFLCAASFLQGMTVNGFINTVITSIERRFDLHSYQSGLIASSYDIAACLCLTFVSYFGGNGHKPRWLGWGALVLGIGSLVFALPHFTAGRYEVEIDDEGLGTETGTCLTNQSQVECKDRASGLSSYRLIFMLGQLLHGVGATPLYTLGVTYLDENVKSSYSPIYIAIFYTAAILGPAAGYLIGGAMLNVYTEVGQRTELTTDSPLWVGAWWIGFLGAGIAAFLIAIPILGYPRQLPGSQRYVVMRAAETQQLKDHSRDNPAFGKTVRDLPLSVWILLRNPTFILLCLAGATEATLIAGMSTFGPKFFEAQFSLSASEAATLFGYLVVPAGGGGTLLGGFLVNKFKLRGSGIIRFCLFCTLTSLLAFFVFLMHCPNVHMAGVTTGYVGSLLPKGQLDLKAACNALYCCQPRHYSPLCGSDGTMYYSPCYAGCPEGAVTGPGGQKVYRGCSCILEKASSGWGNATAGKCASTCQSKPLLLVLVFVVIIFTFLSSIPALTATLRCVCDRQRSFALGIQWIVVRTLGSIPGPIAFGWVIDKACLLWQDQCGHQGSCFVYKNEAMSRYLLIAGLTFKVLGFLFFVAAYFLYKSPSVSSDGLEASLPSQSSASDSPTEQLQSNV
uniprot
proteins
function
FUNCTION: Organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormones 3,3',5-triiodo-L-thyronine (T3), L-thyroxine (T4) and 3,3',5'-triiodo-L-thyronine (rT3), conjugated steroids such as estrone 3-sulfate and estradiol 17-beta glucuronide, bile acids such as taurocholate and prostanoids such as prostaglandin E2, likely operating in a tissue-specific manner (By similarity) (PubMed:11316767). May be involved in uptake of metabolites from the circulation into organs such as kidney, liver or placenta. Possibly drives the selective transport of thyroid hormones and estrogens coupled to an outward glutamate gradient across the microvillous membrane of the placenta (By similarity). The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable). {ECO:0000250|UniProtKB:Q96BD0, ECO:0000269|PubMed:11316767, ECO:0000305}.
uniprot
proteins
mass_dalton
77634
uniprot
proteins
protein_family
Organo anion transporter (TC 2.A.60) family
uniprot
proteins
pubmed
11316767
uniprot
proteins
sequence_length
723
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q96BD0}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 103..123; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 143..163; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 170..194; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 228..258; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 278..298; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 313..337; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 381..402; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 423..446; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 451..473; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 583..605; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 615..640; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 674..691; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins