Krtcap2
entrez
66059
canonical
uniprot
Q5RL79
canonical
ensembl
ENSMUSG00000042747
resolver
ensp
ENSMUSP00000043540
resolver
ensp
ENSMUSP00000130372
resolver
ensp
ENSMUSP00000314663
resolver
enst
ENSMUST00000040888
resolver
enst
ENSMUST00000168900
resolver
genesymbol
Krtcap2
resolver
uniprot
A0A0A0MQN1
resolver
uniprot
Q9CQK5
resolver
uniprot_entry
A0A0A0MQN1_MOUSE
resolver
uniprot_entry
KTAP2_MOUSE
resolver
uniprot_sec
Q9CQK5
resolver
amino_acid_sequence
MVVGTGTSLALSSLLSLLLFAGMQIYSRQLASTEWLTIQGGLLGSGLFVFSLTAFNNLENLVFGKGFQAKIFPEILLCLLLALFASGLIHRVCVTTCFIFSMVGLYYINKISSTLYQATAPVLTPAKITGKGKKRN
uniprot
proteins
function
FUNCTION: Subunit of STT3A-containing oligosaccharyl transferase (OST-A) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). Within the OST-A complex, acts as an adapter that anchors the OST-A complex to the Sec61 complex. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1. {ECO:0000250|UniProtKB:Q8N6L1}.
uniprot
proteins
mass_dalton
14675
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:Q8N6L1}.
uniprot
proteins
protein_family
KRTCAP2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
136
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8N6L1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8N6L1}.
uniprot
proteins
transmembrane_region
TRANSMEM 6..23; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 35..55; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 76..108; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins