Slc6a15
entrez
103098
canonical
uniprot
Q8BG16
canonical
ensembl
ENSMUSG00000019894
resolver
ensp
ENSMUSP00000073829
resolver
ensp
ENSMUSP00000136676
resolver
ensp
ENSMUSP00000243247
resolver
ensp
ENSMUSP00000243251
resolver
ensp
ENSMUSP00000243262
resolver
ensp
ENSMUSP00000243263
resolver
enst
ENSMUST00000074204
resolver
enst
ENSMUST00000179636
resolver
genesymbol
Slc6a15
resolver
genesymbol_syn
B0at2
resolver
genesymbol_syn
Ntt73
resolver
uniprot
Q333Y0
resolver
uniprot_entry
S6A15_MOUSE
resolver
uniprot_sec
Q333Y0
resolver
amino_acid_sequence
MPKNSKVVKRDLDDDVIESVKDLLSNEDSVEEVSKKSELIVDVQEEKDTDAEDGSEADDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLLVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWTLFYFSQSFQQPLPWDQCPLVKNASHTYVEPECEQSSATTYYWYREALDITSSISDSGGLNWKMTVCLLVAWVMVCLAMIKGIQSSGKIMYFSSLFPYVVLICFLIRSLLLNGSIDGIRHMFTPKLEMMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKANIVNEKCISQNSEMILKLLKMGNISWDVIPHHINLSAVTVEDYRLVYDIIQKVKEEEFAVLHLNACQIEDELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMFGTIEGIITPIVDTFKVRKEILTVICCLLAFCIGLIFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVSFVYGIDKFIEDLTDMLGFAPSKYYYYMWKYISPLMLLTLLIASIVNMGLSPPGYNAWIKEKASEEFLSYPMWGMVVCFSLMVLAILPVPVVFIIRRCNLIDDSSGNLASVTYKRGRVLKEPVNLEGDDASLIHGKIPSEMSSPNFGKNIYRKQSGSPTLDTAPNGRYGIGYLMADMPDMPESDL
uniprot
proteins
function
FUNCTION: Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for methionine and for the branched-chain amino acids, particularly leucine, valine and isoleucine. Can also transport low-affinity substrates such as alanine, phenylalanine, glutamine and pipecolic acid (PubMed:16185194). Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent (By similarity). {ECO:0000250|UniProtKB:Q9H2J7, ECO:0000269|PubMed:16185194}.
uniprot
proteins
mass_dalton
81792
uniprot
proteins
protein_family
SLC6A15 subfamily
uniprot
proteins
protein_family
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16185194
uniprot
proteins
pubmed
17931606
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
729
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:16185194}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 70..90; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 98..117; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 142..162; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 226..244; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 253..270; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 306..323; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 335..356; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 453..472; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 496..514; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 530..550; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 571..592; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 620..642; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins