TREM1
entrez
54210
canonical
uniprot
Q9NP99
canonical
ensembl
ENSG00000124731
resolver
ensp
ENSP00000244709
resolver
ensp
ENSP00000334284
resolver
ensp
ENSP00000465345
resolver
ensp
ENSP00000465688
resolver
enst
ENST00000589614
resolver
genesymbol
TREM1
resolver
hgnc
HGNC:17760
resolver
uniprot
B4DWG2
resolver
uniprot
K7EJW1
resolver
uniprot
K7EKM5
resolver
uniprot
Q38L15
resolver
uniprot
Q53FL8
resolver
uniprot
Q5T2C9
resolver
uniprot
Q86YU1
resolver
uniprot_entry
K7EKM5_HUMAN
resolver
uniprot_entry
Q38L15_HUMAN
resolver
uniprot_entry
TREM1_HUMAN
resolver
uniprot_sec
B4DWG2
resolver
uniprot_sec
K7EJW1
resolver
uniprot_sec
Q53FL8
resolver
uniprot_sec
Q5T2C9
resolver
uniprot_sec
Q86YU1
resolver
amino_acid_sequence
MRKTRLWGLLWMLFVSELRAATKLTEEKYELKEGQTLDVKCDYTLEKFASSQKAWQIIRDGEMPKTLACTERPSKNSHPVQVGRIILEDYHDHGLLRVRMVNLQVEDSGLYQCVIYQPPKEPHMLFDRIRLVVTKGFSGTPGSNENSTQNVYKIPPTTTKALCPLYTSPRTVTQAPPKSTADVSTPDSEINLTNVTDIIRVPVFNIVILLAGGFLSKSLVFSVLFAVTLRSFVP
uniprot
proteins
function
FUNCTION: [Isoform 1]: Cell surface receptor that plays important roles in innate and adaptive immunity by amplifying inflammatory responses (PubMed:10799849, PubMed:21393102). Upon activation by various ligands such as PGLYRP1, HMGB1 or HSP70, multimerizes and forms a complex with transmembrane adapter TYROBP/DAP12 (PubMed:17568691, PubMed:25595774, PubMed:29568119). In turn, initiates a SYK-mediated cascade of tyrosine phosphorylation, activating multiple downstream mediators such as BTK, MAPK1, MAPK3 or phospholipase C-gamma (PubMed:14656437, PubMed:21659545). This cascade promotes the neutrophil- and macrophage-mediated release of pro-inflammatory cytokines and/or chemokines, as well as their migration and thereby amplifies inflammatory responses that are triggered by bacterial and fungal infections (PubMed:17098818, PubMed:17568691). By also promoting the amplification of inflammatory signals that are initially triggered by Toll-like receptor (TLR) and NOD-like receptor engagement, plays a major role in the pathophysiology of acute and chronic inflammatory diseases of different etiologies including septic shock and atherosclerosis (PubMed:11323674, PubMed:21393102). {ECO:0000269|PubMed:10799849, ECO:0000269|PubMed:11323674, ECO:0000269|PubMed:14656437, ECO:0000269|PubMed:17098818, ECO:0000269|PubMed:17568691, ECO:0000269|PubMed:21393102, ECO:0000269|PubMed:21659545, ECO:0000269|PubMed:25595774, ECO:0000269|PubMed:29568119}.; FUNCTION: [Isoform 2]: Acts as a decoy receptor, counterbalancing TREM1 pro-inflammatory activity through the neutralization of its ligand. {ECO:0000269|PubMed:26561551}.
uniprot
proteins
mass_dalton
26387
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:10799849}.
uniprot
proteins
pubmed
10799849
uniprot
proteins
pubmed
11323674
uniprot
proteins
pubmed
11922939
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14656437
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15351648
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17098818
uniprot
proteins
pubmed
17568691
uniprot
proteins
pubmed
21393102
uniprot
proteins
pubmed
21659545
uniprot
proteins
pubmed
25595774
uniprot
proteins
pubmed
26561551
uniprot
proteins
pubmed
29568119
uniprot
proteins
sequence_length
234
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:17098818, ECO:0000269|PubMed:21393102}; Single-pass type I membrane protein {ECO:0000305}. Note=Recruited to lipid rafts when activated. {ECO:0000269|PubMed:17098818}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:26561551}.
uniprot
proteins
transmembrane_region
TRANSMEM 206..226; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins