Mapk7
entrez
23939
canonical
uniprot
Q9WVS8
canonical
ensembl
ENSMUSG00000001034
resolver
ensp
ENSMUSP00000078087
resolver
ensp
ENSMUSP00000098646
resolver
ensp
ENSMUSP00000104354
resolver
ensp
ENSMUSP00000219707
resolver
ensp
ENSMUSP00000219717
resolver
enst
ENSMUST00000101085
resolver
genesymbol
Mapk7
resolver
genesymbol_syn
Bmk1
resolver
genesymbol_syn
Erk5
resolver
uniprot
Q3U2N7
resolver
uniprot
Q3UG52
resolver
uniprot
Q497T0
resolver
uniprot
Q5NCN6
resolver
uniprot
Q5NCN7
resolver
uniprot
Q5NCN8
resolver
uniprot
Q5NCN9
resolver
uniprot
Q6QLU8
resolver
uniprot
Q9R1D9
resolver
uniprot
Q9WVF3
resolver
uniprot
Q9WVF4
resolver
uniprot_entry
MK07_MOUSE
resolver
uniprot_entry
Q5NCN8_MOUSE
resolver
uniprot_sec
Q3U2N7
resolver
uniprot_sec
Q3UG52
resolver
uniprot_sec
Q497T0
resolver
uniprot_sec
Q5NCN6
resolver
uniprot_sec
Q5NCN7
resolver
uniprot_sec
Q5NCN9
resolver
uniprot_sec
Q6QLU8
resolver
uniprot_sec
Q9R1D9
resolver
uniprot_sec
Q9WVF3
resolver
uniprot_sec
Q9WVF4
resolver
activity_regulation
ACTIVITY REGULATION: Activated by tyrosine and threonine phosphorylation. Activated in response to hyperosmolarity, hydrogen peroxide, and epidermal growth factor (EGF) (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MAEPLKEEDGEDGSGEPPGRVKAEPVHTAASVVAKNLALLKARSFDVTFDVGDEYEIIETIGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDILKPTVPYGEFRSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIHRDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYTQAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMMVLGTPSPAVIQAVGAERVRAYIQSLPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARISAAAALRHPFLAKYHDPDDEPDCAPPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPVCPDVEMPSPWAPSGDCAMESPPPALPPCSDPAPDTVDLTLQPAPPASELAPPKREGAISDNTKAALKAALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERERKERGAGTLGGPSTDPLAGLVLSDNDRSLLERWTRMARPPAPAPAPAPAPAPAPSSAQPTSTPTGPVSQSTGPLQPAGSIPGPASQPVCPPPGPVPQPAGPIPAPLQTAPSTSLLASQSLVPPSGLPGSGAPEVLPYFPSGPPPPDPGLTPQPSTSESPDVNLVTQQLSKSQVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSFDMGVADGPQDGQADSASLSASLLADWLEGHGMNPADIESLQREIQMDSPMLLSDLPDLQEP
uniprot
proteins
ec_number
2.7.11.24
uniprot
proteins
function
FUNCTION: Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via interaction with STUB1/CHIP and promotion of STUB1-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity). May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression (By similarity). Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P0C865, ECO:0000269|PubMed:11139578, ECO:0000269|PubMed:11278431, ECO:0000269|PubMed:11520859, ECO:0000269|PubMed:15085193, ECO:0000269|PubMed:15716121}.
uniprot
proteins
mass_dalton
87733
uniprot
proteins
post_translational_modification
PTM: Dually phosphorylated on Thr-219 and Tyr-221, which activates the enzyme. {ECO:0000250}.
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
MAP kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10473620
uniprot
proteins
pubmed
11139578
uniprot
proteins
pubmed
11278431
uniprot
proteins
pubmed
11520859
uniprot
proteins
pubmed
15085193
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15716121
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20724525
uniprot
proteins
pubmed
23428871
uniprot
proteins
sequence_length
806
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11139578}. Nucleus {ECO:0000269|PubMed:11139578}. Nucleus, PML body {ECO:0000250}. Note=Translocates to the nucleus upon activation. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Isoform 1 is detected in cytoplasm and nucleus. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000250}. Note=Isoform 2 is detected only in the nucleus. Translocates to the nucleus upon activation (By similarity). {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus {ECO:0000250}. Note=Isoform 2 is detected only in the nucleus. Translocates to the nucleus upon activation (By similarity). {ECO:0000250}.
uniprot
proteins