Fdxr
entrez
14149
canonical
uniprot
Q61578
canonical
ensembl
ENSMUSG00000018861
resolver
ensp
ENSMUSP00000021078
resolver
ensp
ENSMUSP00000292897
resolver
enst
ENSMUST00000021078
resolver
genesymbol
Fdxr
resolver
uniprot_entry
ADRO_MOUSE
resolver
amino_acid_sequence
MAPRCWHWWRWSAWSGLRPSPSRSTPTPGFCQKFSTQEKTPQICVVGSGPAGFYTAQHLLKHHTHAHVDIYEKQLVPFGLVRFGVAPDHPEVKNVINTFTQTARSDRCAFQGNVVVGRDVSVPELREAYHAVVLSYGAEDHQPLGIPGEELPGVVSARAFVGWYNGLPENQELAPDLSCDTAVILGQGNVALDVARILLTPPEHLEKTDITEAALGALRQSRVKTVWIVGRRGPLQVAFTIKELREMIQLPGTRPILDPSDFLGLQDRIKDVPRPRRRLTELLLRTATEKPGVEEAARQALASRAWGLRFFRSPQQVLPTPDGQRVAGIRLAVTSLEGVGESTRAVPTGDVEDLPCGLLLSSVGYKSRPIDPSVPFDPKLGVIPNTEGRVVNVPGLYCSGWVKRGPTGVITTTMTDSFLTSQALLEDLKAGLLPSGPRPGYVAIQALLSNRGVRPVSFSDWEKLDAEEVSRGQGTGKPREKLVDRREMLRLLGH
uniprot
proteins
ec_number
1.18.1.6
uniprot
proteins
function
FUNCTION: Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver (By similarity). Also acts as a ferredoxin--NADP(+) reductase essential for coenzyme Q biosynthesis: together with FDX2, transfers the electrons required for the hydroxylation reaction performed by COQ6 (By similarity). {ECO:0000250|UniProtKB:P08165, ECO:0000250|UniProtKB:P22570}.
uniprot
proteins
mass_dalton
54202
uniprot
proteins
mutagenesis
MUTAGEN 389; /note="R->Q: Decreased NADPH-adrenodoxin reductase activity in tissues from homozygous mice. Homozygous mice show progressive impairment of posterior gait, and visual acuity defects with loss of retinal ganglion cells and abnormal myelination of optic nerve."; /evidence="ECO:0000269|PubMed:29040572
uniprot
proteins
pathway_participation
PATHWAY: Steroid metabolism. {ECO:0000250|UniProtKB:P56522}.
uniprot
proteins
protein_family
Ferredoxin--NADP reductase type 1 family
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29040572
uniprot
proteins
pubmed
29554255
uniprot
proteins
pubmed
7495857
uniprot
proteins
sequence_length
494
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P48360}; Peripheral membrane protein {ECO:0000305}.
uniprot
proteins