Avp
entrez
24221
canonical
uniprot
P01186
canonical
ensembl
ENSRNOG00000021229
resolver
ensembl
ENSRNOG00055006166
resolver
ensembl
ENSRNOG00060006535
resolver
ensembl
ENSRNOG00060017663
resolver
ensembl
ENSRNOG00065014579
resolver
ensp
ENSRNOP00000028833
resolver
ensp
ENSRNOP00055007716
resolver
ensp
ENSRNOP00060007932
resolver
ensp
ENSRNOP00060024379
resolver
ensp
ENSRNOP00065018787
resolver
enst
ENSRNOT00000028833
resolver
enst
ENSRNOT00055009991
resolver
enst
ENSRNOT00060010701
resolver
enst
ENSRNOT00060030207
resolver
enst
ENSRNOT00065024085
resolver
genesymbol
Avp
resolver
uniprot_entry
NEU2_RAT
resolver
amino_acid_sequence
MLAMMLNTTLSACFLSLLALTSACYFQNCPRGGKRATSDMELRQCLPCGPGGKGRCFGPSICCADELGCFLGTAEALRCQEENYLPSPCQSGQKPCGSGGRCAAAGICCSDESCVAEPECREGFFRLTRAREQSNATQLDGPARELLLRLVQLAGTQESVDSAKPRVY
uniprot
proteins
disease_involvement
DISEASE: Note=A spontaneous mutation is the cause of the Brattleboro phenotype, characterized by central diabetes insipidus, resulting in constant thirst and very dilute urine (PubMed:14120453, PubMed:5692127, PubMed:6526016). Defects are caused by the absence of hormone Arg-vasopressin (PubMed:6526016). Brattleboro mutation results in high incidences of fetal and neonatal deaths, behavioral abnormalities in the adults, and small litter size (PubMed:7205775). {ECO:0000269|PubMed:14120453, ECO:0000269|PubMed:5692127, ECO:0000269|PubMed:6526016, ECO:0000269|PubMed:7205775}.
uniprot
proteins
function
FUNCTION: Precursor of Arg-vasopressin, an antidiuretic hormone, and neurophysin 2, its carrier protein. {ECO:0000269|PubMed:1706187}.; FUNCTION: [Arg-vasopressin]: Has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels. Acts by binding to vasopressin receptors (V1bR/AVPR1B, V1aR/AVPR1A, and V2R/AVPR2). {ECO:0000250|UniProtKB:P01185}.; FUNCTION: [Neurophysin 2]: Carrier protein that binds to and transports Arg-vasopressin from the hypothalamus to the posterior pituitary gland, protecting it from degradation and facilitating its release. {ECO:0000269|PubMed:6153132}.
uniprot
proteins
mass_dalton
17923
uniprot
proteins
post_translational_modification
PTM: Synthesized as a large inactive precursor protein, which is cleaved into Arg-vasopressin and neurophysin 2 by endopeptidases, such as neuroendocrine convertases PCSK1 and PCSK2 (PubMed:9523585). Arg-vasopressin is then amidated at the C-terminus, completing its activation (PubMed:5150741). {ECO:0000269|PubMed:5150741, ECO:0000269|PubMed:9523585}.; PTM: [Arg-vasopressin]: Amidated at the C-terminus by alpha-amidating monooxygenase (PAM), completing its activation. {ECO:0000269|PubMed:5150741}.
uniprot
proteins
protein_family
Vasopressin/oxytocin family
uniprot
proteins
pubmed
14120453
uniprot
proteins
pubmed
1706187
uniprot
proteins
pubmed
3768139
uniprot
proteins
pubmed
3956504
uniprot
proteins
pubmed
5150741
uniprot
proteins
pubmed
5692127
uniprot
proteins
pubmed
6153132
uniprot
proteins
pubmed
6315416
uniprot
proteins
pubmed
6526016
uniprot
proteins
pubmed
65791
uniprot
proteins
pubmed
6641941
uniprot
proteins
pubmed
7036996
uniprot
proteins
pubmed
7205775
uniprot
proteins
pubmed
891987
uniprot
proteins
pubmed
9523585
uniprot
proteins
sequence_length
168
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:65791}. Note=The precursor protein is packaged into neurosecretory granules. {ECO:0000269|PubMed:65791}.; SUBCELLULAR LOCATION: [Arg-vasopressin]: Secreted {ECO:0000269|PubMed:65791}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:65791}. Note=Following processing, Arg-vasopressin and neurophysin 2 are transported to the posterior pituitary and stored in neurosecretory granules at the nerve termini until secreted. {ECO:0000269|PubMed:65791}.; SUBCELLULAR LOCATION: [Neurophysin 2]: Secreted {ECO:0000269|PubMed:65791}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:65791}. Note=Following processing, Arg-vasopressin and neurophysin 2 are transported to the posterior pituitary and stored in neurosecretory granules at the nerve termini until secreted. {ECO:0000269|PubMed:65791}.
uniprot
proteins