GPM6A
entrez
2823
canonical
uniprot
P51674
canonical
ensembl
ENSG00000150625
resolver
ensp
ENSP00000280187
resolver
ensp
ENSP00000377268
resolver
ensp
ENSP00000421578
resolver
ensp
ENSP00000423984
resolver
genesymbol
GPM6A
resolver
genesymbol_syn
M6A
resolver
hgnc
HGNC:4460
resolver
uniprot
B7Z642
resolver
uniprot
E9PHI5
resolver
uniprot
Q92602
resolver
uniprot_entry
GPM6A_HUMAN
resolver
uniprot_sec
B7Z642
resolver
uniprot_sec
E9PHI5
resolver
uniprot_sec
Q92602
resolver
amino_acid_sequence
MEENMEEGQTQKGCFECCIKCLGGIPYASLIATILLYAGVALFCGCGHEALSGTVNILQTYFEMARTAGDTLDVFTMIDIFKYVIYGIAAAFFVYGILLMVEGFFTTGAIKDLYGDFKITTCGRCVSAWFIMLTYLFMLAWLGVTAFTSLPVYMYFNLWTICRNTTLVEGANLCLDLRQFGIVTIGEEKKICTVSENFLRMCESTELNMTFHLFIVALAGAGAAVIAMVHYLMVLSANWAYVKDACRMQKYEDIKSKEEQELHDIHSTRSKERLNAYT
uniprot
proteins
function
FUNCTION: Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor. {ECO:0000269|PubMed:19298174}.
uniprot
proteins
mass_dalton
31210
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:24705354}.; PTM: Palmitoylated by ZDHHC17/HIP14. {ECO:0000269|PubMed:24705354}.
uniprot
proteins
protein_family
Myelin proteolipid protein family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
19298174
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
24705354
uniprot
proteins
pubmed
8661015
uniprot
proteins
pubmed
8893821
uniprot
proteins
sequence_length
278
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P35802}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P35802}. Cell projection, axon {ECO:0000250|UniProtKB:P35802}. Cell projection, growth cone {ECO:0000250|UniProtKB:P35802}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q812E9}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q812E9}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q812E9}. Note=Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons. Localized to plasma membrane of cell bodies and neurites of hippocampal neurons. Localized in membrane protrusions (filopodia and spines) of primary hippocampal neurons (By similarity). Localized to the growth cone edge membrane of elongating axons (By similarity). {ECO:0000250|UniProtKB:P35802, ECO:0000250|UniProtKB:Q812E9}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..43; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 85..105; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 128..148; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 214..234; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins