Jtb
entrez
23922
canonical
uniprot
O88824
canonical
ensembl
ENSMUSG00000027937
resolver
ensp
ENSMUSP00000029546
resolver
enst
ENSMUST00000029546
resolver
genesymbol
Jtb
resolver
genesymbol_syn
Gm622
resolver
uniprot
Q542D4
resolver
uniprot
Q9D0T9
resolver
uniprot_entry
JTB_MOUSE
resolver
uniprot_entry
Q542D4_MOUSE
resolver
uniprot_entry
Q9D0T9_MOUSE
resolver
amino_acid_sequence
MLAGAGRRGLPRAGHLCWLLCAFTLKLCEAEAPVREEKLSVSTSTSPCWLAEEFVVTEECTPCSNFQIKTTPECGSTGYVEKITCSSSKRNEFKSCRSALLEQHLFWKFEGVVVAVALVFACLVIVRQRQLDRKALEKVRKQIESI
uniprot
proteins
function
FUNCTION: Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity (By similarity). Inhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential. {ECO:0000250, ECO:0000269|PubMed:17369841}.
uniprot
proteins
mass_dalton
16329
uniprot
proteins
mutagenesis
MUTAGEN 13..14; /note="AG->DD: Abolishes N-terminal proteolytic processing."; /evidence="ECO:0000269|PubMed:17369841
uniprot
proteins
post_translational_modification
PTM: Undergoes N-terminal proteolytic processing, removing a peptide of about 1 kDa from the N-terminus of the protein. {ECO:0000269|PubMed:17369841}.
uniprot
proteins
protein_family
JTB family
uniprot
proteins
pubmed
10321732
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17369841
uniprot
proteins
sequence_length
146
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Mitochondrion {ECO:0000269|PubMed:17369841}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase (By similarity). {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 106..126; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins