Cyp4f3
entrez
290623
canonical
uniprot
Q3MID2
canonical
ensembl
ENSRNOG00000015751
resolver
ensp
ENSRNOP00000098550
resolver
enst
ENSRNOT00000120992
resolver
genesymbol
Cyp4f18
resolver
genesymbol
Cyp4f3
resolver
genesymbol_syn
Cyp4f18
resolver
uniprot
A0ABK0L7D4
resolver
uniprot_entry
A0ABK0L7D4_RAT
resolver
uniprot_entry
CP4F3_RAT
resolver
amino_acid_sequence
MPLLSLSWLGLGHTAASPWLLLLLVGASCLLAYILPQVYAVFENSRRLRRFPQPPPRNWLFGHLGLIQSSEEGLLYIQSLSRTFRDVCCWWVGPWHPVIRIFHPAFIKPVILAPASVAPKDRVFYRFLRPWLGDGLLLSTGDKWSRHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQRLASQGSARLDMFEHISLMTLDSLQKCVFSFDSNCQEKPSEYITAILELSALVARRHQSLLLHVDLFYHLTRDGMRFRKACRLVHDFTDAVIRERRCTLPDQGGDDALKAKAKAKTLDFIDVLLLSKDEHGEALSDEDIRAEADTFMFGGHDTTASGLSWILYNLAKHPEYQERCRQEVRELLRDREPEEIEWDDLAQLPFLTMCIKESLRLHPPATAISRCCTQDIMLPDGRVIPKGVICRISIFGTHHNPAVWPDPEVYNPFRFDADNGKGRSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRVLPDDKEPRRKPELILRAEGGLWLRVEPLSAGAH
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of the pro-inflammatory lipid mediator leukotriene B4 (LTB4). Hydroxylates at the omega-1 and omega-2 positions LTB4. This oxidation step leads to LTB4 inactivation, which is postulated to be a crucial part of the resolution of inflammation. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). {ECO:0000250|UniProtKB:Q99N16}.
uniprot
proteins
mass_dalton
59906
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; leukotriene B4 degradation. {ECO:0000250|UniProtKB:Q99N16}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
524
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q99N16}; Single-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000250|UniProtKB:Q99N16}; Single-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..35; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins