Mmaa
entrez
109136
canonical
uniprot
Q8C7H1
canonical
ensembl
ENSMUSG00000037022
resolver
ensp
ENSMUSP00000048826
resolver
ensp
ENSMUSP00000206189
resolver
ensp
ENSMUSP00000206190
resolver
ensp
ENSMUSP00000206191
resolver
ensp
ENSMUSP00000206192
resolver
ensp
ENSMUSP00000206194
resolver
ensp
ENSMUSP00000206201
resolver
ensp
ENSMUSP00000206202
resolver
ensp
ENSMUSP00000206210
resolver
ensp
ENSMUSP00000206213
resolver
ensp
ENSMUSP00000206221
resolver
ensp
ENSMUSP00000206223
resolver
ensp
ENSMUSP00000206236
resolver
ensp
ENSMUSP00000206242
resolver
ensp
ENSMUSP00000364513
resolver
enst
ENSMUST00000048718
resolver
genesymbol
Mmaa
resolver
uniprot
Q8R2N3
resolver
uniprot
Q8VC22
resolver
uniprot_entry
MMAA_MOUSE
resolver
uniprot_sec
Q8R2N3
resolver
uniprot_sec
Q8VC22
resolver
activity_regulation
ACTIVITY REGULATION: GTPase activity is stimulated by MMUT. {ECO:0000250|UniProtKB:Q8IVH4}.
uniprot
proteins
amino_acid_sequence
MTISTLLLSPNRRLLTCLSRVPSPWLLHSSHPAPGPPGALPNCFGHHCTKRVLLSDGFRRTLCVQATLKDHTEGLSDKEQRFVDRLYTGLVKGQRACLAEAITLVESTHTRKRELAQVLLQRVLALQREQELRNQGKPLTFRVGLSGPPGAGKSTFIECFGKMLTEQGHRLSVLAVDPSSCTSGGSLLGDKTRMIELSRDMNAYIRPSPTSGTLGGVTRTTNEAIVLCEGGGYDIILIETVGVGQSEFAVADMVDMFVLLLPPAGGDELQGIKRGIIEMADLVVITKSDGDLIVPARRIQAEYVSALKLLRRRSEVWRPKVIRISARSGEGITEMWDTMREFQHQMLASGELAAKRQTQHKVWMWNLIQENVLEHFKTHPSIREQIPLMERKVLSGALSPGRAADLLLKAFKSRH
uniprot
proteins
ec_number
3.6.-.-
uniprot
proteins
function
FUNCTION: GTPase, binds and hydrolyzes GTP (By similarity). Involved in intracellular vitamin B12 metabolism, mediates the transport of cobalamin (Cbl) into mitochondria for the final steps of adenosylcobalamin (AdoCbl) synthesis (By similarity). Functions as a G-protein chaperone that assists AdoCbl cofactor delivery from MMAB to the methylmalonyl-CoA mutase (MMUT) (By similarity). Plays a dual role as both a protectase and a reactivase for MMUT (By similarity). Protects MMUT from progressive inactivation by oxidation by decreasing the rate of the formation of the oxidized inactive cofactor hydroxocobalamin (OH2Cbl) (By similarity). Additionally acts a reactivase by promoting the replacement of OH2Cbl by the active cofactor AdoCbl, restoring the activity of MMUT in the presence and hydrolysis of GTP (By similarity). {ECO:0000250|UniProtKB:Q8IVH4}.
uniprot
proteins
mass_dalton
45932
uniprot
proteins
protein_family
ArgK/MeaB subfamily
uniprot
proteins
protein_family
SIMIBI class G3E GTPase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
415
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q8IVH4}. Cytoplasm {ECO:0000250|UniProtKB:Q8IVH4}.
uniprot
proteins