HELZ2
entrez
85441
canonical
uniprot
Q9BYK8
canonical
ensembl
ENSG00000130589
resolver
ensp
ENSP00000417401
resolver
enst
ENST00000467148
resolver
genesymbol
HELZ2
resolver
genesymbol_syn
KIAA1769
resolver
genesymbol_syn
PRIC285
resolver
hgnc
HGNC:30021
resolver
uniprot
A0AAA9XBX5
resolver
uniprot
Q3C2G2
resolver
uniprot
Q4VXQ1
resolver
uniprot
Q8TEF3
resolver
uniprot
Q96ND3
resolver
uniprot
Q9C094
resolver
uniprot_entry
A0AAA9XBX5_HUMAN
resolver
uniprot_entry
HELZ2_HUMAN
resolver
uniprot_sec
Q3C2G2
resolver
uniprot_sec
Q4VXQ1
resolver
uniprot_sec
Q8TEF3
resolver
uniprot_sec
Q96ND3
resolver
uniprot_sec
Q9C094
resolver
amino_acid_sequence
MAPPGSTLLPNSPAATRGPSLARLCALVDLCLGCSRCTQRLNESTYVLRRVEHDCSREILLARFKQATKSKVWRVVGCRPTFPRPLCYQVCHYYSPGLGCRRHRNRCTFARSREEALVWTFERQHNLQRLWLKAEVQGSGAQGGAGRAADAILTEFGGRFELLCSLCFRRCPPCICRVDPQGQCPEHGACPSLLAHVSAEGRRKQQFVVVRPRPRAGQPPAYCRFVGRGQPCWRGESRCQFAHSAVEMAVWEAEQLGGLQRGDLLTPPAPDGDGRTAPLGQPPGAQLYCPACLVTCHSQEAFENHCASSEHAQMVAFDQALPWEHRSPPPGLSKFELCPKPDLCEYGDACTKAHSAQELQEWVRRTQAVELRGQAAWQDGLVPYQERLLAEYQRSSSEVLVLAETLDGVRVTCNQPLMYQAQERKTQYSWTFAVHSEEPLLHVALLKQEPGADFSLVAPGLPPGRLYARGERFRVPSSTADFQVGVRVQAASFGTFEQWVVFDFGRRPVLLQKLGLQLGQGRRPGPCRNLALGHPEEMERWHTGNRHVVPGVERTAEQTALMAKYKGPALALEFNRSSVASGPISPTNYRQRMHQFLYEEEAAQQQLVAKLTLRGQVFLKTALQTPALNMLFAPPGALYAEVPVPSSLMPDTDQGFLLGRAVSTALVAPVPAPDNTVFEVRLERRASSEQALWLLLPARCCLALGLQPEARLVLEVQFQIDPMTFRLWHQAVDTLPEEQLVVPDLPTCALPRPWSVPPLRRGNRKQELAVALIAGWGPGDGRRVPPLLIYGPFGTGKTYTLAMASLEVIRRPETKVLICTHTNSAADIYIREYFHSHVSGGHPEATPLRVMYTDRPLSQTDPVTLQYCCLTDDRQAFRPPTRAELARHRVVVTTTSQARELRVPVGFFSHILIDEAAQMLECEALTPLAYASHGTRLVLAGDHMQVTPRLFSVARARAAEHTLLHRLFLCYQQETHEVARQSRLVFHENYRCTDAIVSFISRHFYVAKGNPIHARGKVPPHPRHYPLMFCHVAGSPDRDMSMASWLNLAEIAQVVEKVQEAYNTWPSCWGGREQRCICVVSHGAQVSALRQELRRRDLGQVSVGSFEILPGRQFRVVVLSTVHTCQSLLSPGALAPEFFTDARVLNTVLTRAQSQLVVVGDAVALCSFGACGKLWESFIRECVERHSVCPEGLSMEQVEQGVAQRRRWPPRGTQAGAAGNWEAAPEPVGDLAEEQAAVVTAMVKAEPGDEALSPASRDITATTAQTEAAAAPAGDAVKEDVVPGACAAGAAAAAGVESTEAEDAEADFWPWDGELNADDAILRELLDESQKVMVTVGEDGLLDTVARPESLQQARLYENLPPAALRKLLHAEPERYRHCSFVPETFERASAIPLDDASSGPIQVRGRLDCGMAFAGDEVLVQLLSGDKAPEGRLRGRVLGVLKRKRHELAFVCRMDTWDPRIMVPINGSVTKIFVAELKDPSQVPIYSLRKGRLQRVGLERLTAEARHSRLFWVQIVLWRQGFYYPLGIVREVLPEASTWEQGLRILGLEYSLRVPPSDQATITKVLQKYHTELGRVAGRREDCRAFLTFTVDPQGACNLDDALSVRDLGPRCEVAVHITDVASFVPRDGVLDVEARRQGAAFYAPGREPVPMLPASLCQDVLSLLPGRDRLAISLFLTMEKASGQLKSLRFAPSVVQSDRQLSYEEAEEVIRQHPGAGRELPARLDSVDACVVAACYFSRLLRRHRLRSDCFYEQPDEDGTLGFRAAHIMVKEYMIQFNRLVAEFLVGSECTRTVTPLRWQPAPRSQQLKALCEKHGDRVPLSLHLGHHLHGGGGSPPDTRLHLLASLWKQVQFAARTQDYEQMVDLVTTDDMHPFLAPAGRDLRKALERSAFGRCARGHQQQGGHYSLQVDWYTWATSPIRRYLDVVLQRQILLALGHGGSAYSARDIDGLCQAFSLQHALAQSYQRRARSLHLAVQLKAQPLDKLGFVVDVEAGSRCFRLLFPSNRETLPDPCPVPYGSLQLAEHPHALAGRPGLRLLWRRRVYSAQGSSPPLPLPGTVPDPHTLAVETALWKQLLELVELQRWPEAAALIQEKGEASQRRELVQVQRSHCGHFLEVARELGSGDTLQVQLGTSLQHGFLVPSPQLWTVAPGFSLCLEHVERPGDCFSGRVYRAPRDRYRDVDEYACVWEPFCALESATGAVAENDSVTLQHLSVSWEASRTPQGQLQGAFRLEAAFLEENCADINFSCCYLCIRLEGLPAPTASPRPGPSSLGPGLNVDPGTYTWVAHGQTQDWDQERRADRQEAPRRVHLFVHHMGMEKVPEEVLRPGTLFTVELLPKQLPDLRKEEAVRGLEEASPLVTSIALGRPVPQPLCRVIPSRFLERQTYNIPGGRHKLNPSQNVAVREALEKPFTVIQGPPGTGKTIVGLHIVFWFHKSNQEQVQPGGPPRGEKRLGGPCILYCGPSNKSVDVLAGLLLRRMELKPLRVYSEQAEASEFPVPRVGSRKLLRKSPREGRPNQSLRSITLHHRIRQAPNPYSSEIKAFDTRLQRGELFSREDLVWYKKVLWEARKFELDRHEVILCTCSCAASASLKILDVRQILVDEAGMATEPETLIPLVQFPQAEKVVLLGDHKQLRPVVKNERLQNLGLDRSLFERYHEDAHMLDTQYRMHEGICAFPSVAFYKSKLKTWQGLRRPPSVLGHAGKESCPVIFGHVQGHERSLLVSTDEGNENSKANLEEVAEVVRITKQLTLGRTVEPQDIAVLTPYNAQASEISKALRREGIAGVAVSSITKSQGSEWRYVLVSTVRTCAKSDLDQRPTKSWLKKFLGFVVDPNQVNVAVTRAQEGLCLIGDHLLLRCCPLWRSLLDFCEAQQTLVPAGQVRVCRRPTMPS
uniprot
proteins
ec_number
3.1.13.1
uniprot
proteins
ec_number
5.6.2.6
uniprot
proteins
function
FUNCTION: Multifunctional nuclear protein involved in RNA surveillance, nuclear receptor-mediated transcriptional regulation, and the restriction of mobile genetic elements as part of the innate immune response (PubMed:37602378). Degrades highly structured RNAs through its concerted ATP-dependent RNA helicase and 3' to 5' exoribonuclease activities (PubMed:37602378). Shows a strong preference for pyrimidine over purine residues for its nuclease activity (PubMed:37602378). Acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA (PubMed:16239304, PubMed:23525231). In addition, regulates lipid metabolism independently of PPARs by controlling the stability of Apob mRNA, which encodes a protein essential for lipoprotein assembly and secretion (PubMed:41446920). Also contributes to adipocyte differentiation through interactions with the splicing factor proline- and glutamine-rich protein SFPQ and THRAP3 (PubMed:34052659, PubMed:23525231). {ECO:0000269|PubMed:16239304, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:34052659, ECO:0000269|PubMed:37602378, ECO:0000269|PubMed:41446920}.
uniprot
proteins
mass_dalton
322316
uniprot
proteins
mutagenesis
MUTAGEN 797; /note="K->A: Partial loss of ability to degrade APOB mRNA."; /evidence="ECO:0000269|PubMed:41446920"; MUTAGEN 1593; /note="D->N: Complete loss of 3'-5' exoribonucleolytic activity; when associated with N-1601 and N-1602."; /evidence="ECO:0000269|PubMed:41446920"; MUTAGEN 1598; /note="C->F: Loss of 3'-5' exoribonuclease activity. No effect on ATP-dependent RNA helicase activity."; /evidence="ECO:0000269|PubMed:37602378"; MUTAGEN 1601; /note="D->N: Complete loss of 3'-5' exoribonucleolytic activity; when associated with N-1593 and N-1602."; /evidence="ECO:0000269|PubMed:41446920"; MUTAGEN 1601; /note="D->N: Loss of 3'-5' exoribonuclease activity."; /evidence="ECO:0000269|PubMed:37602378"; MUTAGEN 1602; /note="D->N: Complete loss of 3'-5' exoribonucleolytic activity; when associated with N-1593 and N-1601."; /evidence="ECO:0000269|PubMed:41446920"; MUTAGEN 1920; /note="S->L: No effect on 3'-5' exoribonuclease and ATP-dependent RNA helicase activity."; /evidence="ECO:0000269|PubMed:37602378"; MUTAGEN 1923; /note="R->L: No effect on 3'-5' exoribonuclease and ATP-dependent helicase activity."; /evidence="ECO:0000269|PubMed:37602378"; MUTAGEN 2151; /note="T->M: Loss of 3'-5' exoribonuclease activity. No effect on ATP-dependent RNA helicase activity."; /evidence="ECO:0000269|PubMed:37602378"; MUTAGEN 2427; /note="K->A: Partial loss of ability to degrade APOB mRNA."; /evidence="ECO:0000269|PubMed:41446920
uniprot
proteins
protein_family
DNA2/NAM7 helicase family
uniprot
proteins
pubmed
11214970
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
12189208
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16239304
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23525231
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
34052659
uniprot
proteins
pubmed
37602378
uniprot
proteins
pubmed
41446920
uniprot
proteins
sequence_length
2896
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:37602378}.
uniprot
proteins