GPR88
entrez
54112
canonical
uniprot
Q9GZN0
canonical
ensembl
ENSG00000181656
resolver
ensp
ENSP00000314223
resolver
enst
ENST00000315033
resolver
genesymbol
GPR88
resolver
genesymbol_syn
STRG
resolver
hgnc
HGNC:4539
resolver
uniprot
Q29S24
resolver
uniprot
Q6VN48
resolver
uniprot_entry
GPR88_HUMAN
resolver
uniprot_sec
Q29S24
resolver
uniprot_sec
Q6VN48
resolver
amino_acid_sequence
MTNSSSTSTSSTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPTGSAEPPADWDGAGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQALYQRRHTAGMLALSWALALGLVLLLPPWAPRPGAAPPRVHYPALLAAAALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPGAQHAPGPGGAAHPAQAQPLPPALHPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAVAATAVPAVSQAQLGTRAAGQHW
uniprot
proteins
disease_involvement
DISEASE: Chorea, childhood-onset, with psychomotor retardation (COCPMR) [MIM:616939]: An autosomal recessive neurodevelopmental disorder characterized by abnormal involuntary movements, marked speech delay, intellectual disability and learning difficulties. {ECO:0000269|PubMed:27123486}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Orphan G protein-coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing (By similarity). May play a role in the regulation of cognitive and motor function (By similarity). Couples with the heterotrimeric G protein complex of the G(i) subfamily, consisting of GNAI1, GNB1 and GNG2, thereby acting through a G(i)-mediated pathway (PubMed:35501348). Plays a role in the attenuation of D1 dopamine receptor (D1R)-mediated cAMP response in ciliated cells (PubMed:23936473). In non-ciliated cells, involved in the inhibition of the beta-2 adrenergic receptor (B2AR) response (PubMed:23936473). {ECO:0000250|UniProtKB:Q9EPB7, ECO:0000250|UniProtKB:Q9ESP4, ECO:0000269|PubMed:23936473, ECO:0000269|PubMed:35501348}.
uniprot
proteins
mass_dalton
40246
uniprot
proteins
mutagenesis
MUTAGEN 84; /note="W->A,I,L,V: Abolishes the responsiveness to synthetic agonist 2-PCCA."; /evidence="ECO:0000269|PubMed:35501348"; MUTAGEN 117; /note="G->F,L,W: Reduced G(i)-coupling activity."; /evidence="ECO:0000269|PubMed:35501348"; MUTAGEN 121; /note="G->F,L,W: Reduced G(i)-coupling activity."; /evidence="ECO:0000269|PubMed:35501348"; MUTAGEN 209; /note="L->A: Reduced G(i)-coupling activity."; /evidence="ECO:0000269|PubMed:35501348"; MUTAGEN 216; /note="V->A,F,L: Reduced G(i)-coupling activity."; /evidence="ECO:0000269|PubMed:35501348"; MUTAGEN 219; /note="V->A: Reduced G(i)-coupling activity."; /evidence="ECO:0000269|PubMed:35501348"; MUTAGEN 283; /note="G->H: Inhibits D1R-dependent cAMP accumulation."; /evidence="ECO:0000269|PubMed:23936473"; MUTAGEN 283; /note="G->V: Retains G(i)-protein-coupled signaling activity. Abolishes the responsiveness to synthetic agonist 2-PCCA."; /evidence="ECO:0000269|PubMed:35501348"; MUTAGEN 287; /note="L->A: Reduced G(i)-coupling activity."; /evidence="ECO:0000269|PubMed:35501348"; MUTAGEN 322; /note="W->A,I,L,V: Abolishes the responsiveness to synthetic agonist 2-PCCA."; /evidence="ECO:0000269|PubMed:35501348
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11056049
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
23936473
uniprot
proteins
pubmed
27123486
uniprot
proteins
pubmed
35501348
uniprot
proteins
sequence_length
384
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9ESP4}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium membrane {ECO:0000269|PubMed:23936473}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q9ESP4}. Nucleus {ECO:0000250|UniProtKB:Q9ESP4}. Note=Localized to cilia in ciliated cells; whereas in non-ciliated cells, distributed throughout the cell membrane (PubMed:23936473). During cortical lamination, subcellular location shifts, on the day of birth, from expression at the plasma membrane and in the cytoplasm to the nuclei of neurons. This intranuclear localization remains throughout adulthood. {ECO:0000250|UniProtKB:Q9ESP4, ECO:0000269|PubMed:23936473}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..56; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 74..94; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 117..136; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 159..179; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 196..216; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 286..306; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 311..331; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins