Slc25a39
entrez
360636
canonical
uniprot
Q4V8K4
canonical
ensembl
ENSRNOG00000020994
resolver
ensembl
ENSRNOG00055028890
resolver
ensembl
ENSRNOG00060014629
resolver
ensembl
ENSRNOG00065032005
resolver
ensp
ENSRNOP00000028496
resolver
ensp
ENSRNOP00055041201
resolver
ensp
ENSRNOP00060019908
resolver
ensp
ENSRNOP00065045310
resolver
enst
ENSRNOT00000028496
resolver
enst
ENSRNOT00055050040
resolver
enst
ENSRNOT00060024987
resolver
enst
ENSRNOT00065055112
resolver
genesymbol
Slc25a39
resolver
uniprot_entry
S2539_RAT
resolver
activity_regulation
ACTIVITY REGULATION: The activity of SLC25A39 is regulated by levels of mitochondrial glutathione via its ability to bind [2Fe-2S] iron-sulfur cluster. Upon physiological levels of mitochondrial glutathione, glutathione prevents iron-sulfur-binding to SLC25A39 promoting cleavage and degradation by AFG3L2. Upon depletion of mitochondrial glutathione, SLC25A39 binds iron-sulfur, preventing cleavage and degradation by AFG3L2. {ECO:0000250|UniProtKB:Q9BZJ4}.
uniprot
proteins
amino_acid_sequence
MDDQDPGGISPLQQMVASGAGAVVTSLFMTPLDVVKVRLQSQRPTVASELTTPSRFWSLSYTKSPSTLQSPGKCLLYCNGVLEPLYLCPNGTRCATWFQDPTRFTGTLDAFVKIVRHEGTRTLWSGLPATLVMTVPATAIYFTAYDQLKAFLCGQSLTSDLYAPMVAGALARMGTVTVVSPLELVRTKLQAQHVSYRELAACVQAAVAQGGWRSLWLGWGPTALRDVPFSALYWFNYELVKSQLNGPRQKEQTSVGISFVAGGISGMVAATLTLPFDVVKTQRQMSLGAVEAMRVKPPRVDSTWLLLRRIQAESGTRGLFAGFLPRIIKAAPSCAIMISTYEFGKSFFHRLNQEQPLGH
uniprot
proteins
function
FUNCTION: Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis. {ECO:0000250|UniProtKB:Q9BZJ4}.
uniprot
proteins
mass_dalton
39235
uniprot
proteins
post_translational_modification
PTM: Cleaved and degraded by AFG3L2; degradation by AFG3L2 is regulated by the ability of SLC25A39 to bind iron-sulfur. In absence of mitochondrial glutathione, SLC25A39 binds iron-sulfur, preventing cleavage and degradation by AFG3L2. The presence of mitochondrial glutathione prevents iron-sulfur-binding to SLC25A39, promoting cleavage and degradation by AFG3L2. {ECO:0000250|UniProtKB:Q9BZJ4}.
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
359
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9BZJ4}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..35; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 122..142; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 165..185; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 215..235; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 256..276; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 318..338; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins