ATP6V1F
entrez
9296
canonical
uniprot
Q16864
canonical
ensembl
ENSG00000128524
resolver
ensp
ENSP00000249289
resolver
ensp
ENSP00000417378
resolver
genesymbol
ATP6V1F
resolver
genesymbol_syn
ATP6S14
resolver
genesymbol_syn
VATF
resolver
hgnc
HGNC:16832
resolver
uniprot
A4D1K0
resolver
uniprot
C9J2K4
resolver
uniprot
Q6IBA8
resolver
uniprot_entry
A4D1K0_HUMAN
resolver
uniprot_entry
VATF_HUMAN
resolver
uniprot_sec
C9J2K4
resolver
uniprot_sec
Q6IBA8
resolver
amino_acid_sequence
MAGRGKLIAVIGDEDTVTGFLLGGIGELNKNRHPNFLVVEKDTTINEIEDTFRQFLNRDDIGIILINQYIAEMVRHALDAHQQSIPAVLEIPSKEHPYDAAKDSILRRARGMFTAEDLR
uniprot
proteins
function
FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (By similarity). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (PubMed:22053050). {ECO:0000250|UniProtKB:Q28029, ECO:0000269|PubMed:22053050, ECO:0000269|PubMed:33065002}.
uniprot
proteins
mass_dalton
13370
uniprot
proteins
protein_family
V-ATPase F subunit family
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22053050
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
33065002
uniprot
proteins
pubmed
8581736
uniprot
proteins
sequence_length
119
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:P50408}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:P50408}; Peripheral membrane protein {ECO:0000305}.
uniprot
proteins