F1M5F3
uniprot
F1M5F3
canonical
amino_acid_sequence
MNSEQVTLVGQVFESYVSEYHKNDILLILKERDEDAHYPLVVNAMTLFETNMEIGDYFTVFPNEVLTVFDSALRRSALAVLQSLPEPEGLSMKQNLHARISGLPVCPELVREHIPKTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKYVFTVKADFEQYYTFSRPSSCPSSDTCDSSKFTCLSDLSASPARCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGVVMQRWKPFQRDMRCEVEIVLKANYVQVNNEQSSGMVMDEDARKEFEDFWEHYKSDPFAGRNEILASLCPQVFGMYLVKLAVAMVLAGGIQRTDAAGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKDSGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYDPQESVSVNIALGSPLLSRFDLILVLLDTRNEDWDRIISSFILENKGYPSKSENLWSMEKMKTYFCLIRNLHPTLSDVSNQVLLRYYQMQRQSDSRNAARTTIRLLESLIRLAEAHARLMFRSTVTLEDAITVVSVMESSMQGGALLGGVNALHTSFPESPRAQYRRQCELILEKLELQSLLQEELRRLERLQNESDQCQPHSPEVEAAPGSCRNDPRDRPGLRTPTQQEQSCSWSPAESSGGDSPTGPGLSRPTSCNHKAEDGGGRGDCLAWADPTASPEIAQESTIVSPGLKTMEEKEDLKISNNGAQGKGKHGLQKRSQLLKPGRLPASGATDTSLRSRGSESTRARQAAVVSEAGRDDDQESGPRRLPRLLKEGSQSVCTTRVRTLPPTVPFPLSISPPGPGKKTGTPKRKRQKSAQVEAPGPEGTETMSAPVVKLAKFTFKQKSKLTHSPEGQGPMPPSASKVAVDSSKIPRQRTRREAGVPAAGPGQSTSTSGDRCSEQLQGQTKALSRQPPESHRPREEKEQGPERRVIQSELELGSQAGHSHPACKKDRKEGASCSNKSKVHAGTMARLANFSFTSPPESKSESLPPERKESRDRSHNPPATTAPVLGQQRQSFQLQQPPERVNLSTLSLFTLSELDDEALDFDWDEEMRKKP
uniprot
proteins
ec_number
5.6.2.4
uniprot
proteins
function
FUNCTION: Component of the MCM8-MCM9 complex, which is involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). The MCM8-MCM9 complex is a 3'-5' DNA helicase and single-stranded (ss)DNA-stimulated ATPase which binds ssDNA in the presence of nucleoside triphosphates. Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs, probably by regulating the localization of the MNR complex. Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand. In addition, recruits MLH1, a component of the MMR complex, to chromatin. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression. Probably by regulating HR, plays a key role during gametogenesis. {ECO:0000250|UniProtKB:Q2KHI9, ECO:0000250|UniProtKB:Q9NXL9}.
uniprot
proteins
mass_dalton
124125
uniprot
proteins
protein_family
MCM family
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
1124
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NXL9}. Chromosome {ECO:0000250|UniProtKB:Q9NXL9}. Note=Colocalizes to nuclear foci with RPA1 following DNA damage. Localizes to double-stranded DNA breaks. Recruited to chromatin by MSH2. {ECO:0000250|UniProtKB:Q9NXL9}.
uniprot
proteins