RAD23B
entrez
5887
canonical
uniprot
P54727
canonical
ensembl
ENSG00000119318
resolver
ensp
ENSP00000350708
resolver
ensp
ENSP00000405623
resolver
genesymbol
RAD23B
resolver
hgnc
HGNC:9813
resolver
uniprot
B3KWK8
resolver
uniprot
B7Z4W4
resolver
uniprot
G5E9P0
resolver
uniprot
Q7Z5K8
resolver
uniprot
Q8WUB0
resolver
uniprot_entry
B7Z4W4_HUMAN
resolver
uniprot_entry
RD23B_HUMAN
resolver
uniprot_sec
B3KWK8
resolver
uniprot_sec
G5E9P0
resolver
uniprot_sec
Q7Z5K8
resolver
uniprot_sec
Q8WUB0
resolver
amino_acid_sequence
MQVTLKTLQQQTFKIDIDPEETVKALKEKIESEKGKDAFPVAGQKLIYAGKILNDDTALKEYKIDEKNFVVVMVTKPKAVSTPAPATTQQSAPASTTAVTSSTTTTVAQAPTPVPALAPTSTPASITPASATASSEPAPASAAKQEKPAEKPAETPVATSPTATDSTSGDSSRSNLFEDATSALVTGQSYENMVTEIMSMGYEREQVIAALRASFNNPDRAVEYLLMGIPGDRESQAVVDPPQAASTGAPQSSAVAAAAATTTATTTTTSSGGHPLEFLRNQPQFQQMRQIIQQNPSLLPALLQQIGRENPQLLQQISQHQEHFIQMLNEPVQEAGGQGGGGGGGSGGIAEAGSGHMNYIQVTPQEKEAIERLKALGFPEGLVIQAYFACEKNENLAANFLLQQNFDED
uniprot
proteins
ec_number
1.14.11.-
uniprot
proteins
function
FUNCTION: Multifunctional protein that participates in histone H4K20 demethylation, DNA repair, ubiquitin-dependent protein degradation and transcriptional regulation (PubMed:10488153, PubMed:32209475, PubMed:9372924). Specifically demethylates mono-, di- and trimethylated 'Lys-20' of histone H4 (H4K20me1, H4K20me2, H4K20me3, respectively) into unmethylated forms. Activates the transcription of coding genes by demethylating H4K20me1 and the transcription of repetitive elements by demethylating H4K20me3 (PubMed:32209475). Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome (PubMed:10488153, PubMed:19435460). May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome (PubMed:15358861). Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex, a nucleotide-excision repair complex that is involved in damage sensing during global genome nucleotide excision repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA. Recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix including single-stranded loops, mismatched bubbles or single-stranded overhangs. Cooperatively with CETN2 appears to stabilize XPC (PubMed:10873465, PubMed:12815074, PubMed:9372924). {ECO:0000269|PubMed:10488153, ECO:0000269|PubMed:10873465, ECO:0000269|PubMed:12815074, ECO:0000269|PubMed:15358861, ECO:0000269|PubMed:19435460, ECO:0000269|PubMed:32209475, ECO:0000269|PubMed:9372924}.
uniprot
proteins
mass_dalton
43171
uniprot
proteins
mutagenesis
MUTAGEN 6; /note="K->A: Impairs interaction with EEF1A1."; /evidence="ECO:0000269|PubMed:16712842
uniprot
proteins
protein_family
RAD23 family
uniprot
proteins
pubmed
10488153
uniprot
proteins
pubmed
10873465
uniprot
proteins
pubmed
10915768
uniprot
proteins
pubmed
11279143
uniprot
proteins
pubmed
12509233
uniprot
proteins
pubmed
12509299
uniprot
proteins
pubmed
12547395
uniprot
proteins
pubmed
12815074
uniprot
proteins
pubmed
12832454
uniprot
proteins
pubmed
14585839
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15064313
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15358861
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15885096
uniprot
proteins
pubmed
15964821
uniprot
proteins
pubmed
16253613
uniprot
proteins
pubmed
16712842
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17323924
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19435460
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19941824
uniprot
proteins
pubmed
20028083
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20798892
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
30455355
uniprot
proteins
pubmed
32209475
uniprot
proteins
pubmed
8168482
uniprot
proteins
pubmed
9372924
uniprot
proteins
pubmed
9734359
uniprot
proteins
sequence_length
409
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16253613, ECO:0000269|PubMed:32209475}. Cytoplasm {ECO:0000269|PubMed:16253613}. Note=The intracellular distribution is cell cycle dependent. Localized to the nucleus and the cytoplasm during G1 phase. Nuclear levels decrease during S-phase; upon entering mitosis, relocalizes in the cytoplasm without association with chromatin. {ECO:0000269|PubMed:16253613}.
uniprot
proteins