Actr3
entrez
81732
canonical
uniprot
Q4V7C7
canonical
ensembl
ENSRNOG00000003206
resolver
ensembl
ENSRNOG00055012714
resolver
ensembl
ENSRNOG00060005995
resolver
ensembl
ENSRNOG00065009582
resolver
ensp
ENSRNOP00000071780
resolver
ensp
ENSRNOP00055017639
resolver
ensp
ENSRNOP00060007495
resolver
ensp
ENSRNOP00065011573
resolver
enst
ENSRNOT00000084552
resolver
enst
ENSRNOT00055021754
resolver
enst
ENSRNOT00060010011
resolver
enst
ENSRNOT00065015383
resolver
genesymbol
Actr3
resolver
genesymbol_syn
Arp3
resolver
uniprot
A9CM89
resolver
uniprot
A9CM90
resolver
uniprot_entry
ARP3_RAT
resolver
uniprot_sec
A9CM89
resolver
uniprot_sec
A9CM90
resolver
amino_acid_sequence
MAGRLPACVVDCGTGYTKLGYAGNTEPQFIIPSCIAIKESAKVGDQAQRRVMKGVDDLDFFIGDEAIEKPTYATKWPIRHGIVEDWDLMERFMEQVIFKYLRAEPEDHYFLLTEPPLNTPENREYTAEIMFESFNVPGLYIAVQAVLALAASWTSRQVGERTLTGTVIDSGDGVTHVIPVAEGYVIGSCIKHIPIAGRDITYFIQQLLRDREVGIPPEQSLETAKAVKERYSYVCPDLVKEFNKYDTDGSKWIKQYTGVNAISKKEFSIDVGYERFLGPEIFFHPEFANPDFTQPISEVVDEVIQNCPIDVRRPLYKNIVLSGGSTMFRDFGRRLQRDLKRTVDARLKLSEELSGGRLKPKPIDVQVITHHMQRYAVWFGGSMLASTPEFYQVCHTKKDYEEIGPSICRHNPVFGVMS
uniprot
proteins
function
FUNCTION: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). Plays a role in ciliogenesis. {ECO:0000250|UniProtKB:P61158}.
uniprot
proteins
mass_dalton
47357
uniprot
proteins
protein_family
ARP3 subfamily
uniprot
proteins
protein_family
Actin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18064521
uniprot
proteins
pubmed
19343716
uniprot
proteins
sequence_length
418
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19343716}. Cell projection {ECO:0000250|UniProtKB:P61158}. Nucleus {ECO:0000250|UniProtKB:P61158}. Note=In pre-apoptotic cells, colocalizes with MEFV in large specks (pyroptosomes). {ECO:0000250|UniProtKB:P61158}.
uniprot
proteins