MYDGF
entrez
56005
canonical
uniprot
Q969H8
canonical
ensembl
ENSG00000074842
resolver
ensp
ENSP00000262947
resolver
enst
ENST00000262947
resolver
genesymbol
MYDGF
resolver
genesymbol_syn
C19orf10
resolver
hgnc
HGNC:16948
resolver
uniprot
D6W628
resolver
uniprot
O75256
resolver
uniprot
O75272
resolver
uniprot
Q9BTK7
resolver
uniprot
Q9NP69
resolver
uniprot_entry
MYDGF_HUMAN
resolver
uniprot_sec
D6W628
resolver
uniprot_sec
O75256
resolver
uniprot_sec
O75272
resolver
uniprot_sec
Q9BTK7
resolver
uniprot_sec
Q9NP69
resolver
amino_acid_sequence
MAAPSGGWNGVGASLWAALLLGAVALRPAEAVSEPTTVAFDVRPGGVVHSFSHNVGPGDKYTCMFTYASQGGTNEQWQMSLGTSEDHQHFTCTIWRPQGKSYLYFTQFKAEVRGAEIEYAMAYSKAAFERESDVPLKTEEFEVTKTAVAHRPGAFKAELSKLVIVAKASRTEL
uniprot
proteins
function
FUNCTION: Bone marrow-derived monocyte and paracrine-acting protein that promotes cardiac myocyte survival and adaptive angiogenesis for cardiac protection and/or repair after myocardial infarction (MI). Stimulates endothelial cell proliferation through a MAPK1/3-, STAT3- and CCND1-mediated signaling pathway. Inhibits cardiac myocyte apoptosis in a PI3K/AKT-dependent signaling pathway (By similarity). Involved in endothelial cell proliferation and angiogenesis (PubMed:25581518). {ECO:0000250|UniProtKB:Q9CPT4, ECO:0000269|PubMed:25581518}.
uniprot
proteins
mass_dalton
18795
uniprot
proteins
mutagenesis
MUTAGEN 172..173; /note="Missing: Increased secretion."; /evidence="ECO:0000269|PubMed:29954947
uniprot
proteins
protein_family
MYDGF family
uniprot
proteins
pubmed
11714798
uniprot
proteins
pubmed
12538725
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17362502
uniprot
proteins
pubmed
19892738
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25581518
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29954947
uniprot
proteins
sequence_length
173
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17362502, ECO:0000269|PubMed:25581518}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:17362502}. Endoplasmic reticulum {ECO:0000269|PubMed:29954947}. Golgi apparatus {ECO:0000269|PubMed:29954947}. Note=The C-terminal RTEL motif may provide retention in the endoplasmic reticulum. {ECO:0000269|PubMed:25581518, ECO:0000269|PubMed:29954947}.
uniprot
proteins