NR1C1
entrez
5465
canonical
uniprot
Q07869
canonical
ensembl
ENSG00000186951
resolver
ensp
ENSP00000385523
resolver
ensp
ENSP00000543527
resolver
ensp
ENSP00000543529
resolver
ensp
ENSP00000543532
resolver
ensp
ENSP00000543536
resolver
ensp
ENSP00000543537
resolver
ensp
ENSP00000543545
resolver
ensp
ENSP00000543549
resolver
ensp
ENSP00000543550
resolver
ensp
ENSP00000543555
resolver
ensp
ENSP00000543556
resolver
ensp
ENSP00000543557
resolver
ensp
ENSP00000612848
resolver
ensp
ENSP00000612849
resolver
ensp
ENSP00000612851
resolver
ensp
ENSP00000612853
resolver
ensp
ENSP00000659872
resolver
ensp
ENSP00000793704
resolver
genesymbol
NR1C1
resolver
genesymbol
PPARA
resolver
genesymbol_syn
NR1C1
resolver
genesymbol_syn
PPAR
resolver
hgnc
HGNC:9232
resolver
uniprot
B0G0X3
resolver
uniprot
F1D8S4
resolver
uniprot
Q16241
resolver
uniprot
Q6I9S0
resolver
uniprot
Q92486
resolver
uniprot
Q92689
resolver
uniprot
Q9Y3N1
resolver
uniprot_entry
F1D8S4_HUMAN
resolver
uniprot_entry
PPARA_HUMAN
resolver
uniprot_sec
B0G0X3
resolver
uniprot_sec
Q16241
resolver
uniprot_sec
Q6I9S0
resolver
uniprot_sec
Q92486
resolver
uniprot_sec
Q92689
resolver
uniprot_sec
Q9Y3N1
resolver
amino_acid_sequence
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
uniprot
proteins
function
FUNCTION: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as a transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. {ECO:0000269|PubMed:10195690, ECO:0000269|PubMed:24043310, ECO:0000269|PubMed:7629123, ECO:0000269|PubMed:7684926, ECO:0000269|PubMed:9556573}.
uniprot
proteins
mass_dalton
52225
uniprot
proteins
mutagenesis
MUTAGEN 122; /note="C->G: Prevents DNA binding but no effect on heterodimerization with RXRA."; /evidence="ECO:0000269|PubMed:7629123"; MUTAGEN 304; /note="D->A: Reduced heterodimerization with RXRA. Reduced DNA binding."; /evidence="ECO:0000269|PubMed:10195690"; MUTAGEN 370; /note="L->R: Abolishes heterodimerization with RXRA. No DNA binding."; /evidence="ECO:0000269|PubMed:10195690"; MUTAGEN 391; /note="L->R: Abolishes heterodimerization with RXRA. No DNA binding."; /evidence="ECO:0000269|PubMed:10195690"; MUTAGEN 422; /note="L->R: No effect on heterodimerization with RXRA nor on DNA binding and transactivation activity."; /evidence="ECO:0000269|PubMed:7629123"; MUTAGEN 431; /note="A->T: No effect on heterodimerization with RXRA nor on DNA binding."; /evidence="ECO:0000269|PubMed:10195690"; MUTAGEN 433; /note="L->R: Abolishes heterodimerization with RXRA, DNA binding and transactivation activity."; /evidence="ECO:0000269|PubMed:7629123
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by E3 ubiquitin-protein ligase HUWE1; leading to proteasomal degradation. {ECO:0000250|UniProtKB:P23204}.; PTM: Phosphorylated. {ECO:0000250|UniProtKB:P37230}.
uniprot
proteins
protein_family
NR1 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
10195690
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
10681503
uniprot
proteins
pubmed
11587644
uniprot
proteins
pubmed
11698662
uniprot
proteins
pubmed
11845213
uniprot
proteins
pubmed
11915042
uniprot
proteins
pubmed
12955147
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
17157019
uniprot
proteins
pubmed
17243659
uniprot
proteins
pubmed
18619963
uniprot
proteins
pubmed
19116277
uniprot
proteins
pubmed
19263263
uniprot
proteins
pubmed
19349176
uniprot
proteins
pubmed
19622862
uniprot
proteins
pubmed
21047783
uniprot
proteins
pubmed
24043310
uniprot
proteins
pubmed
28167758
uniprot
proteins
pubmed
7629123
uniprot
proteins
pubmed
7684926
uniprot
proteins
pubmed
7981125
uniprot
proteins
pubmed
8993548
uniprot
proteins
pubmed
9238002
uniprot
proteins
pubmed
9556573
uniprot
proteins
sequence_length
468
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins