CRYL1
entrez
51084
canonical
uniprot
Q9Y2S2
canonical
ensembl
ENSG00000165475
resolver
ensp
ENSP00000298248
resolver
ensp
ENSP00000493784
resolver
ensp
ENSP00000557681
resolver
enst
ENST00000644593
resolver
genesymbol
CRYL1
resolver
genesymbol
HEL30
resolver
genesymbol_syn
CRY
resolver
hgnc
HGNC:18246
resolver
uniprot
A0A2R8Y4K2
resolver
uniprot
A0PJ43
resolver
uniprot
B3KN92
resolver
uniprot
Q0VDI1
resolver
uniprot
Q7Z4Z9
resolver
uniprot
Q9P0G7
resolver
uniprot
V9HWG2
resolver
uniprot_entry
A0A2R8Y4K2_HUMAN
resolver
uniprot_entry
CRYL1_HUMAN
resolver
uniprot_entry
V9HWG2_HUMAN
resolver
uniprot_sec
A0PJ43
resolver
uniprot_sec
B3KN92
resolver
uniprot_sec
Q0VDI1
resolver
uniprot_sec
Q7Z4Z9
resolver
uniprot_sec
Q9P0G7
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by malonate. {ECO:0000269|PubMed:15809331}.
uniprot
proteins
amino_acid_sequence
MASSAAGCVVIVGSGVIGRSWAMLFASGGFQVKLYDIEQQQIRNALENIRKEMKLLEQAGSLKGSLSVEEQLSLISGCPNIQEAVEGAMHIQECVPEDLELKKKIFAQLDSIIDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEGMLSYCDRYSEGIKHVLQTFGPIPEFSRATAEKVNQDMCMKVPDDPEHLAARRQWRDECLMRLAKLKSQVQPQ
uniprot
proteins
ec_number
1.1.1.45
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of L-gulonate to 3-dehydro-L-gulonate (PubMed:15809331, PubMed:40737316). It also exhibits low dehydrogenase activity toward L-3-hydroxybutyrate (HBA) and L-threonate (PubMed:15809331). Utilizes NAD as the sole cosubstrate and shows no activity with NADP (PubMed:40737316). {ECO:0000269|PubMed:15809331, ECO:0000269|PubMed:40737316}.
uniprot
proteins
mass_dalton
35419
uniprot
proteins
protein_family
3-hydroxyacyl-CoA dehydrogenase family
uniprot
proteins
pubmed
12527201
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15809331
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
40737316
uniprot
proteins
sequence_length
319
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P14755}.
uniprot
proteins