DRAXIN
entrez
374946
canonical
uniprot
Q8NBI3
canonical
ensembl
ENSG00000162490
resolver
ensp
ENSP00000294485
resolver
ensp
ENSP00000525975
resolver
ensp
ENSP00000581451
resolver
enst
ENST00000294485
resolver
enst
ENST00000855916
resolver
enst
ENST00000911392
resolver
genesymbol
DRAXIN
resolver
genesymbol_syn
C1orf187
resolver
hgnc
HGNC:25054
resolver
uniprot
B6EV15
resolver
uniprot
Q5SNX0
resolver
uniprot
Q6UWK8
resolver
uniprot_entry
DRAXI_HUMAN
resolver
uniprot_sec
B6EV15
resolver
uniprot_sec
Q5SNX0
resolver
uniprot_sec
Q6UWK8
resolver
amino_acid_sequence
MAGPAIHTAPMLFLVLLLPLELSLAGALAPGTPARNLPENHIDLPGPALWTPQASHHRRRGPGKKEWGPGLPSQAQDGAVVTATRQASRLPEAEGLLPEQSPAGLLQDKDLLLGLALPYPEKENRPPGWERTRKRSREHKRRRDRLRLHQGRALVRGPSSLMKKAELSEAQVLDAAMEESSTSLAPTMFFLTTFEAAPATEESLILPVTSLRPQQAQPRSDGEVMPTLDMALFDWTDYEDLKPDGWPSAKKKEKHRGKLSSDGNETSPAEGEPCDHHQDCLPGTCCDLREHLCTPHNRGLNNKCFDDCMCVEGLRCYAKFHRNRRVTRRKGRCVEPETANGDQGSFINV
uniprot
proteins
function
FUNCTION: Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. {ECO:0000255|HAMAP-Rule:MF_03060}.
uniprot
proteins
mass_dalton
38650
uniprot
proteins
protein_family
Draxin family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19857465
uniprot
proteins
sequence_length
349
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
uniprot
proteins