Oard1
entrez
106821
canonical
uniprot
Q8R5F3
canonical
ensembl
ENSMUSG00000040771
resolver
ensp
ENSMUSP00000039280
resolver
ensp
ENSMUSP00000130802
resolver
ensp
ENSMUSP00000199600
resolver
ensp
ENSMUSP00000199610
resolver
ensp
ENSMUSP00000199612
resolver
ensp
ENSMUSP00000199614
resolver
ensp
ENSMUSP00000332853
resolver
ensp
ENSMUSP00000332855
resolver
ensp
ENSMUSP00000332857
resolver
enst
ENSMUST00000046651
resolver
enst
ENSMUST00000167180
resolver
genesymbol
Oard1
resolver
uniprot
Q3U5M3
resolver
uniprot_entry
OARD1_MOUSE
resolver
uniprot_sec
Q3U5M3
resolver
activity_regulation
ACTIVITY REGULATION: Subject to competitive inhibition by the product ADP-ribose. {ECO:0000250|UniProtKB:Q9Y530}.
uniprot
proteins
amino_acid_sequence
MATRLNEDPEGSRITYVKGDLFACPKTDSLAHCISEDCRMGAGIAVLFKKRFGGVQELLSQQKKSGEVAVLKRDGRYIYYLITKKRASHKPTYENLQKSLEAMKSHCLKNGVTDLSMPRIGCGLDRLQWENVSAILEEVFESTDIKITVYTL
uniprot
proteins
ec_number
3.2.2.-
uniprot
proteins
ec_number
3.5.1.-
uniprot
proteins
function
FUNCTION: ADP-ribose glycohydrolase that hydrolyzes ADP-ribose and acts on different substrates, such as proteins ADP-ribosylated on glutamate and O-acetyl-ADP-D-ribose. Specifically acts as a glutamate mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to glutamate residues on proteins. Does not act on poly-ADP-ribosylated proteins: the poly-ADP-ribose chain of poly-ADP-ribosylated glutamate residues must by hydrolyzed into mono-ADP-ribosylated glutamate by PARG to become a substrate for OARD1. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. Catalyzes the deacylation of O-acetyl-ADP-ribose, O-propionyl-ADP-ribose and O-butyryl-ADP-ribose, yielding ADP-ribose plus acetate, propionate and butyrate, respectively. {ECO:0000250|UniProtKB:Q9Y530}.
uniprot
proteins
mass_dalton
17107
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
152
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9Y530}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9Y530}. Chromosome {ECO:0000250|UniProtKB:Q9Y530}. Note=Localizes both in the nucleoplasm and in the nucleolus. Relocalizes to the nucleoplasm in response to DNA damage. Recruited to DNA lesion regions following DNA damage. {ECO:0000250|UniProtKB:Q9Y530}.
uniprot
proteins