Ramp3
entrez
56820
canonical
uniprot
Q9JJ73
canonical
genesymbol
Ramp3
resolver
uniprot_entry
RAMP3_RAT
resolver
amino_acid_sequence
MATPAQRLHLLPLLLLLCGECAQVCGCNETGMLERLPRCGKAFAEMMQKVDVWKWCNLSEFIVYYESFTNCTEMETNIVGCYWPNPLAQSFITGIHRQFFSNCTVDRTHWEDPPDEVLIPLIAVPVLLTVAMAGLVVWRSKRTDRLL
uniprot
proteins
function
FUNCTION: Accessory protein that interacts with and modulates the function of G protein-coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL), calcitonin receptor (CALCR) and G protein-coupled estrogen receptor 1 (GPER1) (PubMed:11556887). Required for the transport of CALCRL and GPER1 receptors to the plasma membrane. Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner (By similarity). Together with CALCRL, form a receptor complex for adrenomedullin/ADM and intermedin/ADM2 (PubMed:11556887). Together with CALCR, act as a receptor complex for amylin/IAPP (By similarity). {ECO:0000250|UniProtKB:O60896, ECO:0000269|PubMed:11556887}.
uniprot
proteins
mass_dalton
16781
uniprot
proteins
protein_family
RAMP family
uniprot
proteins
pubmed
11230971
uniprot
proteins
pubmed
11556887
uniprot
proteins
sequence_length
147
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O60896}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O60896}. Membrane {ECO:0000250|UniProtKB:O60896}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O60896}. Note=Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner. {ECO:0000250|UniProtKB:O60896}.
uniprot
proteins
transmembrane_region
TRANSMEM 113..137; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O60896
uniprot
proteins