PANX3
entrez
116337
canonical
uniprot
Q96QZ0
canonical
ensembl
ENSG00000154143
resolver
ensp
ENSP00000284288
resolver
enst
ENST00000284288
resolver
genesymbol
PANX3
resolver
hgnc
HGNC:20573
resolver
uniprot_entry
PANX3_HUMAN
resolver
amino_acid_sequence
MSLAHTAAEYMLSDALLPDRRGPRLKGLRLELPLDRIVKFVAVGSPLLLMSLAFAQEFSSGSPISCFSPSNFSIRQAAYVDSSCWDSLLHHKQDGPGQDKMKSLWPHKALPYSLLALALLMYLPVLLWQYAAVPALSSDLLFIISELDKSYNRSIRLVQHMLKIRQKSSDPYVFWNELEKARKERYFEFPLLERYLACKQRSHSLVATYLLRNSLLLIFTSATYLYLGHFHLDVFFQEEFSCSIKTGLLSDETHVPNLITCRLTSLSIFQIVSLSSVAIYTILVPVIIYNLTRLCRWDKRLLSVYEMLPAFDLLSRKMLGCPINDLNVILLFLRANISELISFSWLSVLCVLKDTTTQKHNIDTVVDFMTLLAGLEPSKPKHLTNSACDEHP
uniprot
proteins
function
FUNCTION: Regulator of osteoblast differentiation by functioning as a Ca(2+) channel in the endoplasmic reticulum which regulates calmodulin (CaM) pathways. Allows ATP release into the extracellular space and activation or purinergic receptors. {ECO:0000250|UniProtKB:Q8CEG0}.
uniprot
proteins
mass_dalton
44683
uniprot
proteins
protein_family
Pannexin family
uniprot
proteins
pubmed
15028292
uniprot
proteins
sequence_length
392
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8CEG0}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351}. Cell junction, gap junction {ECO:0000250|UniProtKB:Q8CEG0}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8CEG0}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00351}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..60; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"; TRANSMEM 114..134; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"; TRANSMEM 216..236; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00351"; TRANSMEM 268..288; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00351
uniprot
proteins