HES6
entrez
55502
canonical
uniprot
Q96HZ4
canonical
ensembl
ENSG00000144485
resolver
ensp
ENSP00000272937
resolver
ensp
ENSP00000387008
resolver
ensp
ENSP00000387155
resolver
genesymbol
HES6
resolver
genesymbol_syn
BHLHB41
resolver
hgnc
HGNC:18254
resolver
uniprot
A8KAP6
resolver
uniprot
B8ZZA9
resolver
uniprot
Q53SN9
resolver
uniprot
Q8N2J2
resolver
uniprot
Q96T93
resolver
uniprot
Q9P2S3
resolver
uniprot_entry
HES6_HUMAN
resolver
uniprot_sec
A8KAP6
resolver
uniprot_sec
B8ZZA9
resolver
uniprot_sec
Q53SN9
resolver
uniprot_sec
Q8N2J2
resolver
uniprot_sec
Q96T93
resolver
uniprot_sec
Q9P2S3
resolver
amino_acid_sequence
MAPPAAPGRDRVGREDEDGWETRGDRKARKPLVEKKRRARINESLQELRLLLAGAEVQAKLENAEVLELTVRRVQGVLRGRAREREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDATVAAELLNHLLESMPLREGSSFQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPPGPGDDLCSDLEEAPEAELSQAPAEGPDLVPAALGSLTTAQIARSVWRPW
uniprot
proteins
function
FUNCTION: Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
24129
uniprot
proteins
pubmed
10851137
uniprot
proteins
pubmed
11044617
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
sequence_length
224
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins