Perp
entrez
64058
canonical
uniprot
Q9JK95
canonical
ensembl
ENSMUSG00000019851
resolver
ensp
ENSMUSP00000019998
resolver
enst
ENSMUST00000019998
resolver
genesymbol
Perp
resolver
genesymbol_syn
Krtcap1
resolver
uniprot
Q9JI77
resolver
uniprot_entry
PERP_MOUSE
resolver
uniprot_sec
Q9JI77
resolver
amino_acid_sequence
MLRCGLACERCRWILPLLLLSAIAFDIIALAGRGWLQSSNHIQTSSLWWRCFDEGGGSGSYDDGCQSLMEYAWGRAAAATLFCGFIILCICFILSFFALCGPQMLVFLRVIGGLLALAAIFQIISLVIYPVKYTQTFRLHDNPAVNYIYNWAYGFGWAATIILIGCSFFFCCLPNYEDDLLGAAKPRYFYPPA
uniprot
proteins
function
FUNCTION: Component of intercellular desmosome junctions (PubMed:15797384). Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly (PubMed:15797384, PubMed:16485031). Thereby plays a role in barrier function of the skin against infection (PubMed:16485031). Plays a role in mammary epithelial tissue homeostasis and remodeling during and after pregnancy, potentially via its involvement in desmosome cell-cell junctions (PubMed:22515648). Required for tooth enamel development via facilitating desmosome-mediated ameloblast adhesion to the stratum intermedium during the transitional stage of amelogenesis (PubMed:21285247). May also play a role in downstream transcriptional regulation of other genes involved in amelogenesis such as AMBN, ENAM, MMP20 and KLK4 (PubMed:21285247). Plays a role as an effector in the TP53-dependent apoptotic pathway (PubMed:10733530). Positively regulates apoptosis in T-helper 17 (Th17) cell populations via caspase-dependent signaling (PubMed:29740445). Promotes neutrophil transepithelial migration in response to chemoattractants such as hepoxilin A3 (HXA3), N-Formylmethionyl-leucyl-phenylalanine (fMLP) and CXCL8/IL-8 (By similarity). May act as a positive regulator of endothelial cell apoptosis in response to blood flow-derived shear stress (By similarity). {ECO:0000250|UniProtKB:E9QHT9, ECO:0000250|UniProtKB:Q96FX8, ECO:0000269|PubMed:10733530, ECO:0000269|PubMed:15797384, ECO:0000269|PubMed:16485031, ECO:0000269|PubMed:21285247, ECO:0000269|PubMed:22515648, ECO:0000269|PubMed:29740445}.
uniprot
proteins
mass_dalton
21567
uniprot
proteins
protein_family
TMEM47 family
uniprot
proteins
pubmed
10733530
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15797384
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16485031
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21285247
uniprot
proteins
pubmed
22515648
uniprot
proteins
pubmed
25486861
uniprot
proteins
pubmed
27834691
uniprot
proteins
pubmed
29740445
uniprot
proteins
sequence_length
193
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, desmosome {ECO:0000269|PubMed:15797384, ECO:0000269|PubMed:22515648}. Cell membrane {ECO:0000269|PubMed:15797384, ECO:0000269|PubMed:21285247, ECO:0000269|PubMed:22515648, ECO:0000269|PubMed:25486861, ECO:0000269|PubMed:27834691}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:25486861, ECO:0000269|PubMed:27834691}. Note=Associated with desmosomes (PubMed:15797384). May translocate to the intestinal apical epithelial cell surface via sipA and sctB1/sipC-promoted exocytic translocation following infection by S. Typhimurium (By similarity). {ECO:0000250|UniProtKB:Q96FX8, ECO:0000269|PubMed:15797384}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 81..101; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 110..130; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 151..171; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins