Prtn3
entrez
19152
canonical
uniprot
Q61096
canonical
ensembl
ENSMUSG00000057729
resolver
ensp
ENSMUSP00000006679
resolver
enst
ENSMUST00000006679
resolver
genesymbol
Prtn3
resolver
uniprot
A0A0R4IZY6
resolver
uniprot
O08809
resolver
uniprot_entry
A0A0R4IZY6_MOUSE
resolver
uniprot_entry
PRTN3_MOUSE
resolver
uniprot_sec
O08809
resolver
amino_acid_sequence
MSGSYPSPKGIHPFLLLALVVGGAVQASKIVGGHEARPHSRPYVASLQLSRFPGSHFCGGTLIHPRFVLTAAHCLQDISWQLVTVVLGAHDLLSSEPEQQKFTISQVFQNNYNPEENLNDVLLLQLNRTASLGKEVAVASLPQQDQTLSQGTQCLAMGWGRLGTQAPTPRVLQELNVTVVTFLCREHNVCTLVPRRAAGICFGDSGGPLICNGILHGVDSFVIRECASLQFPDFFARVSMYVDWIQNVLRGAEP
uniprot
proteins
ec_number
3.4.21.76
uniprot
proteins
function
FUNCTION: Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration. May play a role in neutrophil transendothelial migration, probably when associated with CD177. Triggers inflammatory processes in neutrophils by interacting with ADGRG3 upstream of F2RL1/PAR2 activation. {ECO:0000250|UniProtKB:P24158}.
uniprot
proteins
mass_dalton
27626
uniprot
proteins
protein_family
Elastase subfamily
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9187364
uniprot
proteins
pubmed
9211743
uniprot
proteins
pubmed
9925946
uniprot
proteins
sequence_length
254
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:P24158}. Secreted {ECO:0000250|UniProtKB:P24158}. Cell membrane {ECO:0000250|UniProtKB:P24158}; Peripheral membrane protein {ECO:0000250|UniProtKB:P24158}; Extracellular side {ECO:0000250|UniProtKB:P24158}. Membrane raft {ECO:0000250|UniProtKB:P24158}; Peripheral membrane protein {ECO:0000250|UniProtKB:P24158}; Extracellular side {ECO:0000250|UniProtKB:P24158}. Note=Localizes predominantly to azurophil granules (primary secretory granules) in neutrophils. Secreted upon neutrophil stimulation by TNF, lipopolysaccharide (LPS), fMLP and CXCL8/IL8 or during neutrophil transmigration. Following secretion tethered to the cell membrane by CD177. {ECO:0000250|UniProtKB:P24158}.
uniprot
proteins