Rad54l2
entrez
81000
canonical
uniprot
Q99NG0
canonical
ensembl
ENSMUSG00000040661
resolver
ensp
ENSMUSP00000045454
resolver
genesymbol
Rad54l2
resolver
genesymbol_syn
Arip4
resolver
genesymbol_syn
Srisnf2l
resolver
uniprot
E9QKL0
resolver
uniprot
Q3UPJ1
resolver
uniprot_entry
ARIP4_MOUSE
resolver
uniprot_sec
E9QKL0
resolver
uniprot_sec
Q3UPJ1
resolver
activity_regulation
ACTIVITY REGULATION: Enzyme activity is enhanced by dsDNA (double-stranded DNA) and ssDNA (single-stranded DNA). {ECO:0000269|PubMed:16212558}.
uniprot
proteins
amino_acid_sequence
MSDESASGSDPDLDPDVELEDEEEEEEEEEEVAVEEHDRDDEEGLLDDTSLEGMCGTEHAQLGEDGQRPPRCTSTTSSQSEPSEQLRHQGKILASEDPKKKRAQKPSHMRRNIRKLLREDQLEPVTKAAQQEELERRKRLEQQRKEYAAPIPTVPLEFLPEEIVLRASDGPQLPPRVLAQEVICLDSSSGSEDEKSSRDEVIELSSGEEDTLHIVDSSESVSEEDEEEEKGGTHVNDALNQHDALGRVLVNLNHPPEEENVFLAPQLARAVKPHQIGGIRFLYDNLVESLERFKTSSGFGCILAHSMGLGKTLQVISFIDVLFRHTPAKTVLAIVPVNTLQNWLAEFNMWLPAPEALPADSKPEEVQPRFFKVHILNDEHKTVASRAKVTADWVSEGGVLLMGYEMYRLLTLKKSLATSRPKKTKKRSHPVIIDLDEEDRQQEFRREFEKALCRPGPDVVICDEGHRIKNCQASTSQALKNIRSRRRVVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMFERPILNGQCIDSTPQDVRLMRYRSHVLHSLLEGFVQRRGHTVLKIHLPAKEENVILVRLSQIQRDLYTQFMDRFRDCGTSGWLGLNPLKAFCVCCKIWNHPDVLYEALQKENLANEQDLDVEELGSAGTSARCPPHGTKVKGEDSALPSSMGEATNSKFLQGVGFNPFQERGNNIVTYEWAKELLTNYQTGVLENSPKMVLLFHLIEESVKLGDKILVFSQSLSTLALIEEFLGKRDMPCLPGAEGQGTQKWVRNVSYFRLDGSTPAFERERLINQFNDPSNLTTWLFLLSTRAGCLGVNLIGANRVVVFDASWNPCHDAQAVCRVYRYGQKKPCHIYRLVADYTLEKKIYDRQISKQGMSDRVVDDLNPMLNFTRKEVENLLHFVEKEPAPQTSLDIKGIKESVLQLACLKYPHLITKEPFEHESLLLNRKDHKLTKAEKKAAKKSYEEDKRTSVPYTRPSYAQYYPASDQSLTSIPAFSQRNWQPTLKGDEKPVASVRPVQSTPIPMMPRHVPLSGGVSSASSTNTSMNFPINYLQRAGVLVQKVVTTTDIVIPGLNSSTDVQARINAGESIHIIRGTKGTYIRTSDGRIFAVRATGKPKAPEDGRMAASGSQGPSLASTSNGRHSASSPKAPDPEGLARPVSPDSPEIISELQQYADVAAARESRQSSPSVSAALPGPPGQLMDNSTIPGTALGTEPCLGGHCLNSSLLVTGQPSGGRHPVLDLRGHKRKLATPSVTQESVRRRSRKGHLPAPVQPYEHGYPVSGGFAMPPVSLNHNLTTPFTSQAGENSLFMGSNPSYYQLSNLLADARLVFPVTTDPLVPAGPVSSSSTATSVTASNPSFMLNPSVPGMLPSYSLPFSQPLLSEPRMFAPFPSPGLPSNLSRGVSVYPGYMSPHAGYPAGGLLRSQVPPFDSHEVAEVGFSSNDDEDKDDDVIEVTGK
uniprot
proteins
ec_number
5.6.2.-
uniprot
proteins
function
FUNCTION: DNA helicase that modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner (PubMed:12058073). May stimulate the release of RNA polymerase II, that has paused near the transcription start sites of AR-targeted genes and unwind R-loops formed at these sites; R-loops result from the hybridization of the short RNA strand nascently synthesized by the paused RNA polymerase II molecule and the DNA template (By similarity). May also stimulate double-strand break formation by TOP2B, which appears important for transcriptional output (By similarity). Not able to remodel mononucleosomes in vitro (PubMed:16212558). {ECO:0000250|UniProtKB:Q9Y4B4, ECO:0000269|PubMed:12058073, ECO:0000269|PubMed:16212558}.
uniprot
proteins
mass_dalton
162642
uniprot
proteins
mutagenesis
MUTAGEN 311; /note="K->A: Abolishes ATP-binding."; /evidence="ECO:0000269|PubMed:12058073"; MUTAGEN 362; /note="K->E: Decreased sumoylation; when associated with E-574; E-665; E-936; E-962 and E-1014."; /evidence="ECO:0000269|PubMed:16212558"; MUTAGEN 463..464; /note="DE->AA: Abolishes ATPase activity."; /evidence="ECO:0000269|PubMed:12058073"; MUTAGEN 574; /note="K->E: Decreased sumoylation; when associated with E-362; E-665; E-936; E-962 and E-1014."; /evidence="ECO:0000269|PubMed:16212558"; MUTAGEN 665; /note="K->E: Decreased sumoylation; when associated with E-362; E-574; E-936; E-962 and E-1014."; /evidence="ECO:0000269|PubMed:16212558"; MUTAGEN 936; /note="K->E: Decreased sumoylation; when associated with E-362; E-574; E-665; E-962 and E-1014."; /evidence="ECO:0000269|PubMed:16212558"; MUTAGEN 962; /note="K->E: Decreased sumoylation; when associated with E-362; E-574; E-665; E-936 and E-1014."; /evidence="ECO:0000269|PubMed:16212558"; MUTAGEN 1014; /note="K->E: Decreased sumoylation; when associated with E-362; E-574; E-665; E-936 and E-962."; /evidence="ECO:0000269|PubMed:16212558
uniprot
proteins
post_translational_modification
PTM: Sumoylated. {ECO:0000269|PubMed:16212558}.
uniprot
proteins
protein_family
SNF2/RAD54 helicase family
uniprot
proteins
pubmed
12058073
uniprot
proteins
pubmed
15199138
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16212558
uniprot
proteins
pubmed
17003240
uniprot
proteins
pubmed
17374848
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1467
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12058073, ECO:0000269|PubMed:15199138}. Chromosome {ECO:0000250|UniProtKB:Q9Y4B4}. Note=Localizes in speckle-like nuclear compartments (PubMed:12058073, PubMed:15199138). Localizes to promoter proximal regions on chromatin (By similarity). {ECO:0000250|UniProtKB:Q9Y4B4, ECO:0000269|PubMed:12058073, ECO:0000269|PubMed:15199138}.
uniprot
proteins