TSPAN17
entrez
26262
canonical
uniprot
Q96FV3
canonical
ensembl
ENSG00000048140
resolver
ensp
ENSP00000309036
resolver
ensp
ENSP00000422053
resolver
ensp
ENSP00000426650
resolver
ensp
ENSP00000530667
resolver
ensp
ENSP00000530671
resolver
enst
ENST00000310032
resolver
genesymbol
TSPAN17
resolver
genesymbol_syn
FBXO23
resolver
genesymbol_syn
TM4SF17
resolver
hgnc
HGNC:13594
resolver
uniprot
J3KNG2
resolver
uniprot
Q6NXF7
resolver
uniprot
Q96S98
resolver
uniprot
Q9UKB9
resolver
uniprot_entry
J3KNG2_HUMAN
resolver
uniprot_entry
TSN17_HUMAN
resolver
uniprot_sec
Q6NXF7
resolver
uniprot_sec
Q96S98
resolver
uniprot_sec
Q9UKB9
resolver
amino_acid_sequence
MPGKHQHFQEPEVGCCGKYFLFGFNIVFWVLGALFLAIGLWAWGEKGVLSNISALTDLGGLDPVWLFVVVGGVMSVLGFAGCIGALRENTFLLKFFSVFLGLIFFLELATGILAFVFKDWIRDQLNLFINNNVKAYRDDIDLQNLIDFAQEYWSCCGARGPNDWNLNIYFNCTDLNPSRERCGVPFSCCVRDPAEDVLNTQCGYDVRLKLELEQQGFIHTKGCVGQFEKWLQDNLIVVAGVFMGIALLQIFGICLAQNLVSDIKAVKANW
uniprot
proteins
function
FUNCTION: Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates (PubMed:28600292, PubMed:37516108). Seems to regulate VE-cadherin expression in endothelial cells probably through interaction with ADAM10, promoting leukocyte transmigration (PubMed:28600292). {ECO:0000269|PubMed:28600292, ECO:0000269|PubMed:37516108}.
uniprot
proteins
mass_dalton
30264
uniprot
proteins
protein_family
Tetraspanin (TM4SF) family
uniprot
proteins
pubmed
10531035
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
28600292
uniprot
proteins
pubmed
37516108
uniprot
proteins
sequence_length
270
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9D7W4}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 20..40; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 64..84; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 95..115; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 235..255; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins