TIMP2
entrez
7077
canonical
uniprot
P16035
canonical
ensembl
ENSG00000035862
resolver
ensp
ENSP00000262768
resolver
enst
ENST00000262768
resolver
genesymbol
TIMP2
resolver
hgnc
HGNC:11821
resolver
uniprot
A0A140VK57
resolver
uniprot
Q16121
resolver
uniprot
Q93006
resolver
uniprot
Q9UDF7
resolver
uniprot_entry
A0A140VK57_HUMAN
resolver
uniprot_entry
TIMP2_HUMAN
resolver
uniprot_sec
Q16121
resolver
uniprot_sec
Q93006
resolver
uniprot_sec
Q9UDF7
resolver
amino_acid_sequence
MGAAARTLRLALGLLLLATLLRPADACSCSPVHPQQAFCNADVVIRAKAVSEKEVDSGNDIYGNPIKRIQYEIKQIKMFKGPEKDIEFIYTAPSSAVCGVSLDVGGKKEYLIAGKAEGDGKMHITLCDFIVPWDTLSTTQKKSLNHRYQMGCECKITRCPMIPCYISSPDECLWMDWVTEKNINGHQAKFFACIKRSDGSCAWYRGAAPPKQEFLDIEDP
uniprot
proteins
function
FUNCTION: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19. {ECO:0000269|PubMed:11710594, ECO:0000269|PubMed:2554304, ECO:0000269|PubMed:2793861}.
uniprot
proteins
mass_dalton
24399
uniprot
proteins
post_translational_modification
PTM: The activity of TIMP2 is dependent on the presence of disulfide bonds.
uniprot
proteins
protein_family
Protease inhibitor I35 (TIMP) family
uniprot
proteins
pubmed
11710594
uniprot
proteins
pubmed
12032297
uniprot
proteins
pubmed
1480041
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1655733
uniprot
proteins
pubmed
1730286
uniprot
proteins
pubmed
2157214
uniprot
proteins
pubmed
2380196
uniprot
proteins
pubmed
24073280
uniprot
proteins
pubmed
2554304
uniprot
proteins
pubmed
2793861
uniprot
proteins
pubmed
7918391
uniprot
proteins
pubmed
8112602
uniprot
proteins
pubmed
8810321
uniprot
proteins
pubmed
9705310
uniprot
proteins
pubmed
9837731
uniprot
proteins
sequence_length
220
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins