Pnpla3
entrez
116939
canonical
uniprot
Q91WW7
canonical
ensembl
ENSMUSG00000041653
resolver
ensp
ENSMUSP00000043826
resolver
ensp
ENSMUSP00000209411
resolver
ensp
ENSMUSP00000209422
resolver
enst
ENSMUST00000045289
resolver
genesymbol
Pnpla3
resolver
genesymbol_syn
Adpn
resolver
uniprot
E9QNZ9
resolver
uniprot_entry
E9QNZ9_MOUSE
resolver
uniprot_entry
PLPL3_MOUSE
resolver
amino_acid_sequence
MYDPERRWSLSFAGCGFLGFYHVGATLCLSERAPHLLRDARTFFGCSAGALHAVTFVCSLPLGRIMEILMDLVRKARSRNIGTLHPFFNINKCIRDGLQESLPDNVHQVISGKVHISLTRVSDGENVLVSEFHSKDEVVDALVCSCFIPLFSGLIPPSFRGERYVDGGVSDNVPVLDAKTTITVSPFYGEHDICPKVKSTNFFHVNITNLSLRLCTGNLQLLTRALFPSDVKVMGELCYQGYLDAFRFLEENGICNGPQRSLSLSLVAPEACLENGKLVGDKVPVSLCFTDENIWETLSPELSTALSEAIKDREGYLSKVCNLLPVRILSYIMLPCSLPVESAIAAVHRLVTWLPDIQDDIQWLQWATSQVCARMTMCLLPSTRSRASKDDHRMLKHGHHPSPHKPQGNSAGL
uniprot
proteins
ec_number
2.3.1.51
uniprot
proteins
ec_number
3.1.1.3
uniprot
proteins
ec_number
3.1.1.4
uniprot
proteins
function
FUNCTION: Specifically catalyzes coenzyme A (CoA)-dependent acylation of 1-acyl-sn-glycerol 3-phosphate (2-lysophosphatidic acid/LPA) to generate phosphatidic acid (PA), an important metabolic intermediate and precursor for both triglycerides and glycerophospholipids. Does not esterify other lysophospholipids. Acyl donors are long chain (at least C16) fatty acyl-CoAs: arachidonoyl-CoA, linoleoyl-CoA, oleoyl-CoA and at a lesser extent palmitoyl-CoA (PubMed:22560221). Additionally possesses low triacylglycerol lipase and CoA-independent acylglycerol transacylase activities and thus may play a role in acyl-chain remodeling of triglycerides (By similarity). In vitro may express hydrolytic activity against glycerolipids triacylglycerol, diacylglycerol and monoacylglycerol, with a strong preference for oleic acid as the acyl moiety (By similarity). However, the triacylglycerol hydrolase activity is controversial and may be very low (PubMed:22560221). Possesses phospholipase A2 activity (By similarity). {ECO:0000250|UniProtKB:Q9NST1, ECO:0000269|PubMed:22560221}.
uniprot
proteins
mass_dalton
45772
uniprot
proteins
mutagenesis
MUTAGEN 148; /note="I->M: Increases 1-acylglycerol-3-phosphate O-acyltransferase activity 2-fold; promotes hepatic lipid synthesis."; /evidence="ECO:0000269|PubMed:22560221
uniprot
proteins
pathway_participation
PATHWAY: Phospholipid metabolism. {ECO:0000269|PubMed:22560221}.; PATHWAY: Glycerolipid metabolism. {ECO:0000269|PubMed:22560221}.
uniprot
proteins
pubmed
11431482
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22560221
uniprot
proteins
sequence_length
413
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:11431482, ECO:0000269|PubMed:22560221}; Single-pass membrane protein {ECO:0000269|PubMed:11431482}. Lipid droplet {ECO:0000269|PubMed:22560221}.
uniprot
proteins
transmembrane_region
TRANSMEM 43..63; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins