ARF1
entrez
375
canonical
uniprot
P84077
canonical
ensembl
ENSG00000143761
resolver
ensp
ENSP00000272102
resolver
ensp
ENSP00000514653
resolver
ensp
ENSP00000514654
resolver
ensp
ENSP00000514657
resolver
ensp
ENSP00000532393
resolver
ensp
ENSP00000532394
resolver
ensp
ENSP00000532395
resolver
ensp
ENSP00000532397
resolver
ensp
ENSP00000532398
resolver
ensp
ENSP00000532399
resolver
ensp
ENSP00000532400
resolver
ensp
ENSP00000532401
resolver
ensp
ENSP00000532402
resolver
ensp
ENSP00000532403
resolver
ensp
ENSP00000532404
resolver
ensp
ENSP00000532405
resolver
ensp
ENSP00000532406
resolver
ensp
ENSP00000532407
resolver
ensp
ENSP00000532408
resolver
ensp
ENSP00000532409
resolver
ensp
ENSP00000532410
resolver
ensp
ENSP00000532411
resolver
ensp
ENSP00000532412
resolver
ensp
ENSP00000532413
resolver
ensp
ENSP00000532414
resolver
ensp
ENSP00000596406
resolver
ensp
ENSP00000596407
resolver
ensp
ENSP00000596408
resolver
ensp
ENSP00000596409
resolver
ensp
ENSP00000623515
resolver
ensp
ENSP00000623516
resolver
ensp
ENSP00000623517
resolver
ensp
ENSP00000623518
resolver
ensp
ENSP00000623519
resolver
enst
ENST00000272102
resolver
enst
ENST00000470558
resolver
enst
ENST00000478336
resolver
enst
ENST00000478424
resolver
enst
ENST00000862334
resolver
enst
ENST00000862335
resolver
enst
ENST00000862336
resolver
enst
ENST00000862338
resolver
enst
ENST00000862339
resolver
enst
ENST00000862340
resolver
enst
ENST00000862341
resolver
enst
ENST00000862342
resolver
enst
ENST00000862343
resolver
enst
ENST00000862344
resolver
enst
ENST00000862345
resolver
enst
ENST00000862346
resolver
enst
ENST00000862347
resolver
enst
ENST00000862348
resolver
enst
ENST00000862349
resolver
enst
ENST00000862350
resolver
enst
ENST00000862351
resolver
enst
ENST00000862352
resolver
enst
ENST00000862353
resolver
enst
ENST00000862354
resolver
enst
ENST00000862355
resolver
enst
ENST00000926347
resolver
enst
ENST00000926348
resolver
enst
ENST00000926349
resolver
enst
ENST00000926350
resolver
enst
ENST00000953456
resolver
enst
ENST00000953457
resolver
enst
ENST00000953458
resolver
enst
ENST00000953459
resolver
enst
ENST00000953460
resolver
genesymbol
ARF1
resolver
hgnc
HGNC:652
resolver
uniprot
P10947
resolver
uniprot
P32889
resolver
uniprot_entry
ARF1_HUMAN
resolver
uniprot_sec
P10947
resolver
uniprot_sec
P32889
resolver
activity_regulation
ACTIVITY REGULATION: Alternates between an inactive GDP-bound form and an active GTP-bound form (PubMed:10022920, PubMed:10102276, PubMed:15107860). Intrinsic GTPase activity is almost undetectable in vitro (PubMed:10022920, PubMed:15107860). Activated by guanine nucleotide-exchange factors (GEFs) and inactivated by GTPase-activating proteins (GAPs) (PubMed:10022920, PubMed:10102276, PubMed:15107860). {ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:10102276, ECO:0000269|PubMed:15107860}.
uniprot
proteins
amino_acid_sequence
MGNIFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLSNQLRNQK
uniprot
proteins
disease_involvement
DISEASE: Periventricular nodular heterotopia 8 (PVNH8) [MIM:618185]: A form of periventricular nodular heterotopia, a disorder resulting from a defect in the pattern of neuronal migration in which ectopic collections of neurons lie along the lateral ventricles of the brain or just beneath, contiguously or in isolated patches. PVNH8 is an autosomal dominant disease characterized by developmental disabilities, speech delay, seizures and attention deficit-hyperactivity disorder. {ECO:0000269|PubMed:28868155}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Small GTPase involved in protein trafficking between different compartments (PubMed:8253837). Modulates vesicle budding and uncoating within the Golgi complex (PubMed:8253837). In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane (PubMed:8253837). The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (PubMed:8253837). The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasticity of excitatory synapses and spine shrinkage during long-term depression (LTD) (By similarity). Plays a key role in the regulation of intestinal stem cells and gut microbiota, and is essential for maintaining intestinal homeostasis (By similarity). Also plays a critical role in mast cell expansion but not in mast cell maturation by facilitating optimal mTORC1 activation (By similarity). {ECO:0000250|UniProtKB:P84079, ECO:0000269|PubMed:8253837}.; FUNCTION: (Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. {ECO:0000305}.
uniprot
proteins
mass_dalton
20697
uniprot
proteins
mutagenesis
MUTAGEN 71; /note="Q->L: Inhibits GTP hydrolysis. Coatomer proteins recruitment to the Golgi membrane and formation of coated vesicles are normal. However, Golgi transport is severely reduced due to impaired vesicle uncoating."; /evidence="ECO:0000269|PubMed:8253837
uniprot
proteins
post_translational_modification
PTM: (Microbial infection) Demyristoylated by S.flexneri cysteine protease IpaJ which cleaves the peptide bond between N-myristoylated Gly-2 and Asn-3. {ECO:0000269|PubMed:20213681, ECO:0000269|PubMed:23535599}.
uniprot
proteins
protein_family
Arf family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10022920
uniprot
proteins
pubmed
10102276
uniprot
proteins
pubmed
11950392
uniprot
proteins
pubmed
14690595
uniprot
proteins
pubmed
15107860
uniprot
proteins
pubmed
15308674
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1577740
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17347647
uniprot
proteins
pubmed
17555535
uniprot
proteins
pubmed
1899243
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20213681
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21454700
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
23535599
uniprot
proteins
pubmed
23889934
uniprot
proteins
pubmed
24058294
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2474826
uniprot
proteins
pubmed
25255805
uniprot
proteins
pubmed
25807930
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28868155
uniprot
proteins
pubmed
36261523
uniprot
proteins
pubmed
7990966
uniprot
proteins
pubmed
8253837
uniprot
proteins
pubmed
8861955
uniprot
proteins
pubmed
9110174
uniprot
proteins
sequence_length
181
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:17555535}; Lipid-anchor {ECO:0000269|PubMed:17555535}; Cytoplasmic side {ECO:0000305}. Synapse, synaptosome {ECO:0000250|UniProtKB:P84079}. Postsynaptic density {ECO:0000250|UniProtKB:P84079}. Note=In the GDP-bound form, associates transiently with the membranes via its myristoylated N-terminus where guanine nucleotide-exchange factor (GEF)-mediated nucleotide exchange occurs (By similarity). Following nucleotide exchange, the GTP-bound form undergoes a conformational change, leading to the exposure of a myristoylated N-terminal amphipathic helix that provides stable membrane anchorage (By similarity). {ECO:0000250|UniProtKB:P84080}.
uniprot
proteins