AFF1
entrez
4299
canonical
uniprot
P51825
canonical
ensembl
ENSG00000172493
resolver
ensp
ENSP00000305689
resolver
ensp
ENSP00000378578
resolver
ensp
ENSP00000440843
resolver
ensp
ENSP00000501252
resolver
ensp
ENSP00000605062
resolver
genesymbol
AFF1
resolver
genesymbol_syn
AF4
resolver
genesymbol_syn
FEL
resolver
genesymbol_syn
MLLT2
resolver
genesymbol_syn
PBM1
resolver
hgnc
HGNC:7135
resolver
uniprot
B4DJU9
resolver
uniprot
B4DTU1
resolver
uniprot
E9PBM3
resolver
uniprot
Q14C88
resolver
uniprot_entry
AFF1_HUMAN
resolver
uniprot_entry
B4DJU9_HUMAN
resolver
uniprot_entry
Q14C88_HUMAN
resolver
uniprot_sec
B4DTU1
resolver
uniprot_sec
E9PBM3
resolver
amino_acid_sequence
MAAQSSLYNDDRNLLRIREKERRNQEAHQEKEAFPEKIPLFGEPYKTAKGDELSSRIQNMLGNYEEVKEFLSTKSHTHRLDASENRLGKPKYPLIPDKGSSIPSSSFHTSVHHQSIHTPASGPLSVGNISHNPKMAQPRTEPMPSLHAKSCGPPDSQHLTQDRLGQEGFGSSHHKKGDRRADGDHCASVTDSAPERELSPLISLPSPVPPLSPIHSNQQTLPRTQGSSKVHGSSNNSKGYCPAKSPKDLAVKVHDKETPQDSLVAPAQPPSQTFPPPSLPSKSVAMQQKPTAYVRPMDGQDQAPSESPELKPLPEDYRQQTFEKTDLKVPAKAKLTKLKMPSQSVEQTYSNEVHCVEEILKEMTHSWPPPLTAIHTPSTAEPSKFPFPTKDSQHVSSVTQNQKQYDTSSKTHSNSQQGTSSMLEDDLQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESESSSSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPPEGPRSTEPPRRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQTVGTKQPKKPVKASARAGSRTSLQGEREPGLLPYGSRDQTSKDKPKVKTKGRPRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQGPPHSGSGSRTSGCRQAVVVQEDSRKDRLPLPLRDTKLLSPLRDTPPPQSLMVKITLDLLSRIPQPPGKGSRQRKAEDKQPPAGKKHSSEKRSSDSSSKLAKKRKGEAERDCDNKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALKRSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEHKGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQKAELMTDRVGKAFKYLEAVLSFIECGIATESESQSSKSAYSVYSETVDLIKFIMSLKSFSDATAPTQEKIFAVLCMRCQSILNMAMFRCKKDIAIKYSRTLNKHFESSSKVAQAPSPCIASTGTPSPLSPMPSPASSVGSQSSAGSVGSSGVAATISTPVTIQNMTSSYVTITSHVLTAFDLWEQAEALTRKNKEFFARLSTNVCTLALNSSLVDLVHYTRQGFQQLQELTKTP
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving AFF1 is associated with acute leukemias. Translocation t(4;11)(q21;q23) with KMT2A/MLL1. The result is a rogue activator protein.
uniprot
proteins
function
FUNCTION: Plays an essential role in the activation of transcription elongation from RNA polymerase II promoters, after transcriptional pausing in response to DNA damage. Upon DNA damage, AFF1-mediated transcriptional recovery requires AFF1 poly-ADP-ribosylation by PARP1. {ECO:0000269|PubMed:41062835}.
uniprot
proteins
mass_dalton
131422
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by SIAH1. {ECO:0000269|PubMed:41062835}.; PTM: Poly-ADP-ribosylated by PARP1 on serine residues between aminoacids 601-900 in response to DNA damage; poly-ADP-ribosylation by PARP1 enhances AFF1 stability after DNA damage by preventing SIAH1-mediated ubiquitination and degradation. {ECO:0000269|PubMed:41062835}.
uniprot
proteins
protein_family
AF4 family
uniprot
proteins
pubmed
1423625
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22195968
uniprot
proteins
pubmed
22895430
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23260655
uniprot
proteins
pubmed
41062835
uniprot
proteins
pubmed
8443374
uniprot
proteins
pubmed
8506309
uniprot
proteins
sequence_length
1210
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:41062835}. Note=Associates with chromatin and is recruited to DNA damage sites in a PARP1-dependent manner. {ECO:0000269|PubMed:41062835}.
uniprot
proteins