S1pr4
entrez
13611
canonical
uniprot
Q9Z0L1
canonical
ensembl
ENSMUSG00000044199
resolver
ensp
ENSMUSP00000050412
resolver
enst
ENSMUST00000053646
resolver
genesymbol
S1pr4
resolver
genesymbol_syn
Edg6
resolver
genesymbol_syn
Lpc1
resolver
genesymbol_syn
S1p4
resolver
uniprot
Q3U4H3
resolver
uniprot
Q8C6E2
resolver
uniprot
Q8K1R9
resolver
uniprot_entry
S1PR4_MOUSE
resolver
uniprot_sec
Q3U4H3
resolver
uniprot_sec
Q8C6E2
resolver
uniprot_sec
Q8K1R9
resolver
amino_acid_sequence
MNISTWSTLVTPESCHRLAASGHSLLIVLHYNHSGRLASRGGSEDGGGLGMLRGPSVAAGCLVVLENAMVLAAIAIYMRSRRWVYYCLLNITLSDLLTGLAYVVNVLLSGTRTFQLSPVHWFLREGLLFMALAASTFSLLFTAGERFATMVRVAESGATKTSRVYGCIGLCWLLAAILGLLPLLGWNCVCAFPRCSSLLPLYSKGYVLFCVVVFALILVAILSLYGAIFRVVRANGQKSPRPPARRKSRRLLNTVLMILVAFVVCWGPLFGLLLADIFGSNVWAQEYLRGMDWILALAVFNSAINPLIYSFRSREVQRAVLAFLCCGCLWLGLRGPGDCLTRITEAHSGASTTDSSLRPRDSFRTSRSLSFRMREPLSSISSVRST
uniprot
proteins
function
FUNCTION: G protein-coupled receptor highly expressed in immune cells, where it regulates immune response and cytokine production. Functions as a receptor for the lysosphingolipid sphingosine-1-phosphate (S1P). Upon S1P binding, promotes regulatory T-cell differentiation and enhances fatty acid oxidation, through activation of the NRF2/PPARA signaling pathway (PubMed:39007959). Modulates also M1 macrophage activation through interaction with FPR2 and the JNK signaling, thereby contributing to the inflammatory response (PubMed:37056936). In addition, facilitates early neutrophil mobilization and vascular activation during inflammation, promoting lymphocyte recruitment to draining lymph nodes and supporting the development of germinal centers for an effective adaptive immune response (PubMed:39188715). {ECO:0000250|UniProtKB:O95977, ECO:0000269|PubMed:37056936, ECO:0000269|PubMed:39007959, ECO:0000269|PubMed:39188715}.
uniprot
proteins
mass_dalton
42263
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12401211
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
37056936
uniprot
proteins
pubmed
39007959
uniprot
proteins
pubmed
39188715
uniprot
proteins
pubmed
9790765
uniprot
proteins
sequence_length
386
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 57..77; /note="Helical; Name=1"; /evidence="ECO:0000250"; TRANSMEM 88..108; /note="Helical; Name=2"; /evidence="ECO:0000250"; TRANSMEM 121..141; /note="Helical; Name=3"; /evidence="ECO:0000250"; TRANSMEM 164..184; /note="Helical; Name=4"; /evidence="ECO:0000250"; TRANSMEM 209..229; /note="Helical; Name=5"; /evidence="ECO:0000250"; TRANSMEM 255..275; /note="Helical; Name=6"; /evidence="ECO:0000250"; TRANSMEM 291..311; /note="Helical; Name=7"; /evidence="ECO:0000250
uniprot
proteins