Prr5l
entrez
72446
canonical
uniprot
A2AVJ5
canonical
ensembl
ENSMUSG00000032841
resolver
ensp
ENSMUSP00000042167
resolver
ensp
ENSMUSP00000127530
resolver
ensp
ENSMUSP00000130152
resolver
ensp
ENSMUSP00000219422
resolver
enst
ENSMUST00000043845
resolver
enst
ENSMUST00000163762
resolver
enst
ENSMUST00000171088
resolver
genesymbol
Prr5l
resolver
genesymbol_syn
Protor2
resolver
uniprot
B7ZWM2
resolver
uniprot
Q80Y78
resolver
uniprot
Q8BIT0
resolver
uniprot_entry
PRR5L_MOUSE
resolver
uniprot_sec
B7ZWM2
resolver
uniprot_sec
Q80Y78
resolver
uniprot_sec
Q8BIT0
resolver
amino_acid_sequence
MTRGLAPLLPIEFHKMGSFRRPRPRFMSSPVLSELPRFQAARQALQLSSNSAWNSVQTAVINVFKGGGLQSNELYALNESIRRLLKSELGSFITDYFQNQLLAKGLSFVEEKIKLCEGDNRIEVLAEVWDHFFTETLPTLQAIFYPVQGQELTIRQISLLGFRDLVLLKVKLGDVLLLAQSKLPSSVIQMLLILQSVHEPTGPSEGYLQLEELVKQVVSPFLSISGDRSCSGPTYSLARRHSRVRPKVTVLNYASLMTTVGRPLNEMVLTPLTEQEGEAYLEKCGSVRRHTVANAHSDIQLLAMATMMHSGLGEEAGGEDKHLLLPPSFPPPHRQCSSEPSILDSPDELELEDVASGSQEDSELNCASLS
uniprot
proteins
function
FUNCTION: Associates with the mTORC2 complex that regulates cellular processes including survival and organization of the cytoskeleton (By similarity). Regulates the activity of the mTORC2 complex in a substrate-specific manner preventing for instance the specific phosphorylation of PKCs and thereby controlling cell migration (PubMed:22609986). Plays a role in the stimulation of ZFP36-mediated mRNA decay of several ZFP36-associated mRNAs, such as TNF and GM-CSF, in response to stress. Required for ZFP36 localization to cytoplasmic stress granule (SG) and P-body (PB) in response to stress. {ECO:0000250|UniProtKB:Q6MZQ0, ECO:0000269|PubMed:22609986}.
uniprot
proteins
mass_dalton
40982
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Ubiquitination by RFFL promotes proteasomal degradation of PRR5L thereby modifying the substrate-specific activity of the mTORC2 complex. Ubiquitination by RFFL is stimulated by LPA/lysophosphatidic acid (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
PROTOR family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22609986
uniprot
proteins
sequence_length
370
uniprot
proteins