Dgkb
entrez
54248
canonical
uniprot
P49621
canonical
ensembl
ENSRNOG00000030771
resolver
ensp
ENSRNOP00000058842
resolver
ensp
ENSRNOP00000082015
resolver
ensp
ENSRNOP00000106123
resolver
enst
ENSRNOT00000063874
resolver
enst
ENSRNOT00000111621
resolver
genesymbol
Dgkb
resolver
genesymbol_syn
Dagk2
resolver
uniprot
A0A8I5ZWT2
resolver
uniprot
F1LP01
resolver
uniprot_entry
A0A8I5ZWT2_RAT
resolver
uniprot_entry
DGKB_RAT
resolver
uniprot_entry
F1LP01_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by calcium. {ECO:0000269|PubMed:7689223}.
uniprot
proteins
amino_acid_sequence
MTNQEKWAHLSPSEFSQLQKYAEYSTKKLKDVLEEFHGNGVLAKYNPEGKQDILNQTIDFEGFKLFMKTFLEAELPDDFTAHLFMSFSNKFPHSSPNVKSKPALLSGGLRMNKGAITPPRSSPANTCFPEVIHLKDIVCYLSLLERGRPEDKLEFMFRLYDTDGNGFLDSSELENIIGQMMHVAEYLEWDVTELNPILHEMMEEIDYDRDGTVSLEEWIQGGMTTIPLLVLLGLENNVKDDGQHVWRLKHFNKPAYCNLCLNMLIGVGKQGLCCSFCKYTVHERCARAPPSCIKTYVKSKKNTDVMHHYWVEGNCPTKCDKCHKTVKCYQGLTGLHCVWCQTTLHNKCASHLKPECDCGPLKDHILPPTTICPVVLTMPTAGTSVPEERQSTAKKEKGSSQQPNKVTDKNKMQRANSVTMDGQGLQITPIPGTHPLLVFVNPKSGGKQGERIYRKFQYLLNPRQVYSLSGNGPMPGLHFFRDVPDFRVLACGGDGTVGWILDCIEKANVVKHPPVAILPLGTGNDLARCLRWGGGYEGENLMKILKDIESSTEIMLDRWKFEVTPNDKDEKGDPVPYSIINNYFSIGVDASIAHRFHIMREKHPEKFNSRMKNKFWYFEFGTSETFSATCKKLHESVEIECDGVQIDLINISLQGIAILNIPSMHGGSNLWGESKKKRSHRRIEKKGSDKRPTLTDAKELKFASQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSSVVIRTSKSLPMQIDGEPWMQTPCTIKITHKNQAPMLMGPPPKTGLFCSLIKRTRNRSKE
uniprot
proteins
ec_number
2.7.1.107
uniprot
proteins
function
FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:23949095, PubMed:7689223). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol (PubMed:7689223). Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation (By similarity). {ECO:0000250|UniProtKB:Q6NS52, ECO:0000269|PubMed:23949095, ECO:0000269|PubMed:7689223, ECO:0000305}.
uniprot
proteins
mass_dalton
90288
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; glycerolipid metabolism. {ECO:0000305|PubMed:7689223}.
uniprot
proteins
protein_family
Eukaryotic diacylglycerol kinase family
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23949095
uniprot
proteins
pubmed
7689223
uniprot
proteins
sequence_length
801
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000305|PubMed:7689223}; Peripheral membrane protein {ECO:0000305|PubMed:7689223}. Cell membrane {ECO:0000305|PubMed:7689223}; Peripheral membrane protein {ECO:0000305|PubMed:7689223}. Cytoplasm {ECO:0000305|PubMed:7689223}. Note=Translocation to the plasma membrane is induced by phorbol esters. {ECO:0000250|UniProtKB:Q9Y6T7}.
uniprot
proteins