IL36B
entrez
27177
canonical
uniprot
Q9NZH7
canonical
ensembl
ENSG00000136696
resolver
ensp
ENSP00000259213
resolver
ensp
ENSP00000328420
resolver
genesymbol
IL36B
resolver
genesymbol_syn
IL1F8
resolver
genesymbol_syn
IL1H2
resolver
hgnc
HGNC:15564
resolver
uniprot
Q3MIH0
resolver
uniprot
Q53SR6
resolver
uniprot
Q7RTZ7
resolver
uniprot
Q9UHA5
resolver
uniprot_entry
IL36B_HUMAN
resolver
uniprot_sec
Q3MIH0
resolver
uniprot_sec
Q53SR6
resolver
uniprot_sec
Q7RTZ7
resolver
uniprot_sec
Q9UHA5
resolver
amino_acid_sequence
MNPQREAAPKSYAIRDSRQMVWVLSGNSLIAAPLSRSIKPVTLHLIACRDTEFSDKEKGNMVYLGIKGKDLCLFCAEIQGKPTLQLKLQGSQDNIGKDTCWKLVGIHTCINLDVRESCFMGTLDQWGIGVGRKKWKSSFQHHHLRKKDKDFSSMRTNIGMPGRM
uniprot
proteins
function
FUNCTION: Cytokine that binds to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP. Stimulates production of interleukin-6 and interleukin-8 in synovial fibrobasts, articular chondrocytes and mature adipocytes. Induces expression of a number of antimicrobial peptides including beta-defensins 4 and 103 as well as a number of matrix metalloproteases. Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. In cultured keratinocytes induces the expression of macrophage, T-cell, and neutrophil chemokines, such as CCL3, CCL4, CCL5, CCL2, CCL17, CCL22, CL20, CCL5, CCL2, CCL17, CCL22, CXCL8, CCL20 and CXCL1, and the production of pro-inflammatory cytokines such as TNF, IL-8 and IL-6. {ECO:0000269|PubMed:16646978, ECO:0000269|PubMed:20300079, ECO:0000269|PubMed:21242515, ECO:0000269|PubMed:21881584, ECO:0000269|PubMed:21965679, ECO:0000269|PubMed:24829417}.
uniprot
proteins
mass_dalton
18522
uniprot
proteins
post_translational_modification
PTM: N-terminal truncation leads to a dramatic enhancement of its activity (>1000-fold). {ECO:0000269|PubMed:21965679}.
uniprot
proteins
protein_family
IL-1 family
uniprot
proteins
pubmed
10625660
uniprot
proteins
pubmed
10744718
uniprot
proteins
pubmed
11991722
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16646978
uniprot
proteins
pubmed
20300079
uniprot
proteins
pubmed
21242515
uniprot
proteins
pubmed
21881584
uniprot
proteins
pubmed
21965679
uniprot
proteins
pubmed
24829417
uniprot
proteins
pubmed
32272059
uniprot
proteins
sequence_length
164
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:32272059}. Secreted {ECO:0000269|PubMed:16646978}. Note=The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. {ECO:0000269|PubMed:32272059}.
uniprot
proteins