TMEM266
entrez
123591
canonical
uniprot
Q2M3C6
canonical
ensembl
ENSG00000169758
resolver
ensp
ENSP00000373594
resolver
ensp
ENSP00000572796
resolver
ensp
ENSP00000572797
resolver
ensp
ENSP00000572798
resolver
enst
ENST00000388942
resolver
enst
ENST00000902737
resolver
enst
ENST00000902738
resolver
enst
ENST00000902739
resolver
genesymbol
TMEM266
resolver
genesymbol_syn
C15orf27
resolver
genesymbol_syn
HVRP1
resolver
hgnc
HGNC:26763
resolver
uniprot
Q8N993
resolver
uniprot
Q96LL5
resolver
uniprot_entry
TM266_HUMAN
resolver
uniprot_sec
Q8N993
resolver
uniprot_sec
Q96LL5
resolver
amino_acid_sequence
MTNPQPAIEGGISEVEIISQQVDEETKSIAPVQLVNFAYRDLPLAAVDLSTAGSQLLSNLDEDYQREGSNWLKPCCGKRAAVWQVFLLSASLNSFLVACVILVVILLTLELLIDIKLLQFSSAFQFAGVIHWISLVILSVFFSETVLRIVVLGIWDYIENKIEVFDGAVIILSLAPMVASTVANGPRSPWDAISLIIMLRIWRVKRVIDAYVLPVKLEMEMVIQQYEKAKVIQDEQLERLTQICQEQGFEIRQLRAHLAQQDLDLAAEREAALQAPHVLSQPRSRFKVLEAGTWDEETAAESVVEELQPSQEATMKDDMNSYISQYYNGPSSDSGVPEPAVCMVTTAAIDIHQPNISSDLFSLDMPLKLGGNGTSATSESASRSSVTRAQSDSSQTLGSSMDCSTAREEPSSEPGPSPPPLPSQQQVEEATVQDLLSSLSEDPCPSQKALDPAPLARPSPAGSAQTSPELEHRVSLFNQKNQEGFTVFQIRPVIHFQPTVPMLEDKFRSLESKEQKLHRVPEA
uniprot
proteins
function
FUNCTION: Voltage-sensor protein present on the post-synaptic side of glutamatergic mossy fibers and granule cells in the cerebellum (PubMed:25165868, PubMed:30810529). Despite the presence of a voltage-sensor segment, does not form a functional ion channel and its precise role remains unclear (PubMed:25165868, PubMed:30810529). Undergoes both rapid and slow structural rearrangements in response to changes in voltage (PubMed:30810529). Contains a zinc-binding site that can regulate the slow conformational transition (PubMed:30810529). {ECO:0000269|PubMed:25165868, ECO:0000269|PubMed:30810529}.
uniprot
proteins
mass_dalton
57626
uniprot
proteins
mutagenesis
MUTAGEN 103..108; /note="VVILLT->DVILVL: Despite residues related to HVCN1 channel, does not show ion channel activity; when associated with 151-M--I-145, A-167, L-176-D-177, A-205 and 217-N--S-214."; /evidence="ECO:0000269|PubMed:25165868"; MUTAGEN 143..145; /note="SET->MEI: Despite residues related to HVCN1 channel, does not show ion channel activity; when associated with 111-D--L-108, A-167, L-176-D-177, A-205 and 217-N--S-214."; /evidence="ECO:0000269|PubMed:25165868"; MUTAGEN 167; /note="G->A: Despite residues related to HVCN1 channel, does not show ion channel activity; when associated with 111-D--L-108, 151-M--I-145, L-176-D-177, A-205 and 217-N--S-214."; /evidence="ECO:0000269|PubMed:25165868"; MUTAGEN 176..177; /note="PM->LD: Despite residues related to HVCN1 channel, does not show ion channel activity; when associated with 111-D--L-108, 151-M--I-145, A-167, A-205 and 217-N--S-214."; /evidence="ECO:0000269|PubMed:25165868"; MUTAGEN 205; /note="K->A: Despite residues related to HVCN1 channel, does not show ion channel activity; when associated with 111-D--L-108, 151-M--I-145, A-167, L-176-D-177 and 217-N--S-214."; /evidence="ECO:0000269|PubMed:25165868"; MUTAGEN 209..214; /note="DAYVLP->NGYVLS: Despite residues related to HVCN1 channel, does not show ion channel activity; when associated with 111-D--L-108, 151-M--I-145, A-167, L-176-D-177 and A-205."; /evidence="ECO:0000269|PubMed:25165868
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
22020278
uniprot
proteins
pubmed
25165868
uniprot
proteins
pubmed
30810529
uniprot
proteins
sequence_length
523
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22020278, ECO:0000269|PubMed:25165868}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000269|PubMed:25165868}. Perikaryon {ECO:0000269|PubMed:25165868}. Note=Present in the dendrites and soma of cerebellar granule neurons, but not in their axon. {ECO:0000269|PubMed:25165868}.
uniprot
proteins
transmembrane_region
TRANSMEM 95..115; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255, ECO:0000303|PubMed:30810529"; TRANSMEM 122..142; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255, ECO:0000303|PubMed:30810529"; TRANSMEM 162..182; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255, ECO:0000303|PubMed:30810529"; TRANSMEM 192..212; /note="Helical; Name=Segment S4"; /evidence="ECO:0000303|PubMed:30810529
uniprot
proteins