Fbxl5
entrez
242960
canonical
uniprot
Q8C2S5
canonical
ensembl
ENSMUSG00000039753
resolver
ensp
ENSMUSP00000045792
resolver
ensp
ENSMUSP00000084733
resolver
ensp
ENSMUSP00000113557
resolver
ensp
ENSMUSP00000143703
resolver
ensp
ENSMUSP00000301826
resolver
ensp
ENSMUSP00000301828
resolver
ensp
ENSMUSP00000301831
resolver
ensp
ENSMUSP00000301835
resolver
ensp
ENSMUSP00000301838
resolver
ensp
ENSMUSP00000301839
resolver
ensp
ENSMUSP00000301842
resolver
ensp
ENSMUSP00000301846
resolver
ensp
ENSMUSP00000301848
resolver
ensp
ENSMUSP00000301849
resolver
ensp
ENSMUSP00000301850
resolver
ensp
ENSMUSP00000301856
resolver
enst
ENSMUST00000119523
resolver
genesymbol
Fbxl5
resolver
uniprot
D3Z584
resolver
uniprot
Q14CG1
resolver
uniprot
Q3TAK6
resolver
uniprot
Q3TWC9
resolver
uniprot
Q3UC66
resolver
uniprot
Q80XI5
resolver
uniprot
Q8BGF5
resolver
uniprot
Q8BNL3
resolver
uniprot
Q8C3Q8
resolver
uniprot_entry
D3Z584_MOUSE
resolver
uniprot_entry
FBXL5_MOUSE
resolver
uniprot_sec
Q14CG1
resolver
uniprot_sec
Q3TAK6
resolver
uniprot_sec
Q3TWC9
resolver
uniprot_sec
Q3UC66
resolver
uniprot_sec
Q80XI5
resolver
uniprot_sec
Q8BGF5
resolver
uniprot_sec
Q8BNL3
resolver
uniprot_sec
Q8C3Q8
resolver
activity_regulation
ACTIVITY REGULATION: An iron-sulfur cluster promotes IRP2 polyubiquitination and degradation in response to both iron and oxygen concentrations. {ECO:0000250|UniProtKB:Q9UKA1}.
uniprot
proteins
amino_acid_sequence
MAPFPDEVDVFTAPHWRMKQLVGRYCDKLSKTNFSNNNDFRALLQSLYATFKEFKMHEQIENEYIIGLLQQRSQTIYNVHSDNKLSEMLSLFEKGLKNVKNEYEQLNYAKQLKERLEAFTRDFLPHMKEEEEVFQPMLMEYFTYEELKDIKKKVIAQHCSQKDTAELLRGLSLWNQAEERQKVLKYSVDEKADTEAEVSEHSTGITHLPPEVMLSIFSYLNPQELCRCSQVSTKWSQLAKTGSLWKHLYPVHWARGDWYSGPATELDTEPDEEWVRNRKDESRAFQEWDEDADIDESEESAEESVAISIAQMEKRVLHGLIHNVLPYVGTSVKTLVLAYSSAVSSKMVRQILELCPNLEHLDLTQTDISDSAFDSWSWLGCCQSLRHLDLSGCEKITDMALEKISRALGVLTSHQSGFLKSAGKAASTPWTSKDITMPSTTQYACLHNLTDKGIGEEIDNEHSWTEPVSSESLTSPYVWMLDAEDLADIEDAVEWRHRNVESLCVMETASNFGCSSSGCYSKDIVGLRTSVCWQQHCASPAFAYCGHSFCCTGTALRTMTTLPATSAMCRKALRTTLPRGKDLIYFGSEKSDQETGRVLLFLSLSGCYQITDHGLRALTLGGGLPYLEHLNLSGCLTVTGAGLQDLVSACPSLNDEYFYYCDNINGPHADTASGCQNLQCGFRACCRSGE
uniprot
proteins
function
FUNCTION: Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2 (PubMed:21907140, PubMed:23135277). The C-terminal domain of FBXL5 contains a redox-sensitive [2Fe-2S] cluster that, upon oxidation, promotes binding to IRP2 to effect its oxygen-dependent degradation. Under iron deficiency conditions, the N-terminal hemerythrin-like (Hr) region, which contains a diiron metal center, cannot bind iron and undergoes conformational changes that destabilize the FBXL5 protein and cause its ubiquitination and degradation. When intracellular iron levels start rising, the Hr region is stabilized. Additional increases in iron levels facilitate the assembly and incorporation of a redox active [2Fe-2S] cluster in the C-terminal domain. Only when oxygen level is high enough to maintain the cluster in its oxidized state can FBXL5 recruit IRP2 as a substrate for polyubiquitination and degradation. Promotes ubiquitination and subsequent degradation of the dynactin complex component DCTN1. Within the nucleus, promotes the ubiquitination of SNAI1; preventing its interaction with DNA and promoting its degradation. Negatively regulates DNA damage response by mediating the ubiquitin-proteasome degradation of the DNA repair protein NABP2 (By similarity). {ECO:0000250|UniProtKB:Q9UKA1, ECO:0000269|PubMed:21907140, ECO:0000269|PubMed:23135277}.
uniprot
proteins
mass_dalton
77894
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Polybiquitinated upon iron and oxygen depletion, leading to its degradation by the proteasome. Ubiquitination is regulated by the hemerythrin-like region that acts as an oxygen and iron sensor. Undergoes constitutive ubiquitin-dependent degradation at the steady state by HERC2. {ECO:0000250|UniProtKB:Q9UKA1}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21907140
uniprot
proteins
pubmed
23135277
uniprot
proteins
sequence_length
690
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9UKA1}. Nucleus {ECO:0000250|UniProtKB:Q9UKA1}.
uniprot
proteins