Bap1
entrez
104416
canonical
uniprot
Q99PU7
canonical
ensembl
ENSMUSG00000021901
resolver
ensp
ENSMUSP00000022458
resolver
ensp
ENSMUSP00000276357
resolver
enst
ENSMUST00000022458
resolver
genesymbol
Bap1
resolver
genesymbol_syn
Kiaa0272
resolver
uniprot
Q3TCR6
resolver
uniprot
Q6ZQE6
resolver
uniprot_entry
BAP1_MOUSE
resolver
uniprot_sec
Q3TCR6
resolver
uniprot_sec
Q6ZQE6
resolver
amino_acid_sequence
MNKGWLELESDPGLFTLLVEDFGVKGVQVEEIYDLQSKCQGPVYGFIFLFKWIEERRSRRKVSTLVDDTSVIDDDIVNNMFFAHQLIPNSCATHALLSVLLNCSNVDLGPTLSRMKDFTKGFSPESKGYAIGNAPELAKAHNSHARPEPRHLPEKQNGLSAVRTMEAFHFVSYVPITGRLFELDGLKVYPIDHGPWGEDEEWTDKARRVIMERIGLATAGEPYHDIRFNLMAVVPDRRIKYETRLHVLKVNRQTVLEALQQLIRVTQPELIQTHKSQESQLPEESKPASSKSPLGLEAGRTPVASECTQTDGAEEVAGSCPQTTTHSPPSKCKLVVKPPGSSLNGVPPNPAPIVQRLPAFLDNHNYAKSPMQEEEDLAAGVGRSRVPVRAPQQYSEDEDDYEDEDEDVQNTNPAIRYKRKGTGKPGSLSNSSDGQLSVLQPNTINVLTEKLQESQKDLSVPLSIKTSSGAGSPAVAVPTHSQPSPTPSNESTDTASEIGSAFNSPLRSPIRSANPTRPSSPVTSHISKVLFGEDDSLLRVDCIRYNRAVRDLGPVISTGLLHLAEDGVLSPLALTEGGKGSSPSTRSSQGSQGSSGLEEKEVVEVTESRDKPGLNRSSEPLSGEKYSPKELLALLKCVEAEIANYEACLKEEVEKRKKFKIDDQRRTHNYDEFICTFISMLAQEGMLANLVEQNISVRRRQGVSIGRLHKQRKPDRRKRSRPYKAKRQ
uniprot
proteins
ec_number
3.4.19.12
uniprot
proteins
function
FUNCTION: Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 (By similarity) (PubMed:35446349). Catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (By similarity) (PubMed:32747411, PubMed:35446349). Does not deubiquitinate monoubiquitinated histone H2B (By similarity). The PR-DUB complex is an epigenetic regulator of gene expression and acts as a transcriptional coactivator, affecting genes involved in development, cell communication, signaling, cell proliferation and cell viability (By similarity) (PubMed:32747411, PubMed:35446349). Antagonizes PRC1 mediated H2AK119ub1 monoubiquitination (By similarity). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (By similarity) (PubMed:32747411). Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to counteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration (By similarity). Negatively regulates epithelial-mesenchymal transition (EMT) of trophoblast stem cells during placental development by regulating genes involved in epithelial cell integrity, cell adhesion and cytoskeletal organization (PubMed:34170818). {ECO:0000250|UniProtKB:Q92560, ECO:0000269|PubMed:32747411, ECO:0000269|PubMed:34170818, ECO:0000269|PubMed:35446349}.
uniprot
proteins
mass_dalton
80492
uniprot
proteins
mutagenesis
MUTAGEN 91; /note="C->A: Abolishes ability to suppress tumorigenicity when expressed in NCI-H226 cells."; /evidence="ECO:0000269|PubMed:18757409"; MUTAGEN 716..721; /note="RRKRSR->AAAAAA: Abolishes ability to suppress tumorigenicity when expressed in NCI-H226 cells."; /evidence="ECO:0000269|PubMed:18757409
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated: monoubiquitinated at multiple sites within its nuclear localization signal (NLS) BY UBE2O, leading to cytoplasmic retention. Able to mediate autodeubiquitination via intramolecular interactions to counteract cytoplasmic retention. Monoubiquitinated on at least 4 sites near or within its PY-NLS. {ECO:0000250|UniProtKB:Q92560}.
uniprot
proteins
protein_family
BAP1 subfamily
uniprot
proteins
protein_family
Peptidase C12 family
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18757409
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32747411
uniprot
proteins
pubmed
34170818
uniprot
proteins
pubmed
35446349
uniprot
proteins
pubmed
9528852
uniprot
proteins
sequence_length
728
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q92560}. Nucleus {ECO:0000269|PubMed:34170818}. Chromosome {ECO:0000269|PubMed:32747411}. Note=Mainly nuclear. Binds to chromatin. Localizes to the cytoplasm when monoubiquitinated by the E2/E3 hybrid ubiquitin-protein ligase UBE2O (By similarity). Recruitment to chromatin is dependent on ASXL1/2/3 and recruitment to specific genes on FOXK1/2 (PubMed:32747411). Nuclear localization is redundantly mediated by the importin and transportin systems; TNPO1/transportin-1 is the major mediator of nuclear localization (By similarity). {ECO:0000250|UniProtKB:Q92560, ECO:0000269|PubMed:32747411}.
uniprot
proteins