ITGB2
entrez
3689
canonical
uniprot
P05107
canonical
ensembl
ENSG00000160255
resolver
ensp
ENSP00000347279
resolver
ensp
ENSP00000380948
resolver
ensp
ENSP00000380950
resolver
ensp
ENSP00000380955
resolver
ensp
ENSP00000498780
resolver
ensp
ENSP00000579470
resolver
ensp
ENSP00000579472
resolver
ensp
ENSP00000579473
resolver
ensp
ENSP00000579474
resolver
ensp
ENSP00000579475
resolver
ensp
ENSP00000579476
resolver
ensp
ENSP00000579477
resolver
ensp
ENSP00000579478
resolver
ensp
ENSP00000579479
resolver
ensp
ENSP00000579480
resolver
ensp
ENSP00000631861
resolver
ensp
ENSP00000631862
resolver
ensp
ENSP00000631863
resolver
enst
ENST00000355153
resolver
enst
ENST00000397850
resolver
enst
ENST00000397852
resolver
enst
ENST00000397857
resolver
enst
ENST00000652462
resolver
enst
ENST00000909411
resolver
enst
ENST00000909413
resolver
enst
ENST00000909414
resolver
enst
ENST00000909415
resolver
enst
ENST00000909416
resolver
enst
ENST00000909417
resolver
enst
ENST00000909418
resolver
enst
ENST00000909419
resolver
enst
ENST00000909420
resolver
enst
ENST00000909421
resolver
enst
ENST00000961802
resolver
enst
ENST00000961803
resolver
enst
ENST00000961804
resolver
genesymbol
ITGB2
resolver
genesymbol_syn
CD18
resolver
genesymbol_syn
MFI7
resolver
hgnc
HGNC:6155
resolver
uniprot
A0A494C0X7
resolver
uniprot
B3KTS8
resolver
uniprot
B4E0R1
resolver
uniprot
D3DSM1
resolver
uniprot
Q16418
resolver
uniprot
Q53HS5
resolver
uniprot
Q9UD72
resolver
uniprot_entry
A0A494C0X7_HUMAN
resolver
uniprot_entry
B4E0R1_HUMAN
resolver
uniprot_entry
ITB2_HUMAN
resolver
uniprot_sec
B3KTS8
resolver
uniprot_sec
D3DSM1
resolver
uniprot_sec
Q16418
resolver
uniprot_sec
Q53HS5
resolver
uniprot_sec
Q9UD72
resolver
amino_acid_sequence
MLGLRPPLLALVGLLSLGCVLSQECTKFKVSSCRECIESGPGCTWCQKLNFTGPGDPDSIRCDTRPQLLMRGCAADDIMDPTSLAETQEDHNGGQKQLSPQKVTLYLRPGQAAAFNVTFRRAKGYPIDLYYLMDLSYSMLDDLRNVKKLGGDLLRALNEITESGRIGFGSFVDKTVLPFVNTHPDKLRNPCPNKEKECQPPFAFRHVLKLTNNSNQFQTEVGKQLISGNLDAPEGGLDAMMQVAACPEEIGWRNVTRLLVFATDDGFHFAGDGKLGAILTPNDGRCHLEDNLYKRSNEFDYPSVGQLAHKLAENNIQPIFAVTSRMVKTYEKLTEIIPKSAVGELSEDSSNVVHLIKNAYNKLSSRVFLDHNALPDTLKVTYDSFCSNGVTHRNQPRGDCDGVQINVPITFQVKVTATECIQEQSFVIRALGFTDIVTVQVLPQCECRCRDQSRDRSLCHGKGFLECGICRCDTGYIGKNCECQTQGRSSQELEGSCRKDNNSIICSGLGDCVCGQCLCHTSDVPGKLIYGQYCECDTINCERYNGQVCGGPGRGLCFCGKCRCHPGFEGSACQCERTTEGCLNPRRVECSGRGRCRCNVCECHSGYQLPLCQECPGCPSPCGKYISCAECLKFEKGPFGKNCSAACPGLQLSNNPVKGRTCKERDSEGCWVAYTLEQQDGMDRYLIYVDESRECVAGPNIAAIVGGTVAGIVLIGILLLVIWKALIHLSDLREYRRFEKEKLKSQWNNDNPLFKSATTTVMNPKFAES
uniprot
proteins
disease_involvement
DISEASE: Leukocyte adhesion deficiency 1 (LAD1) [MIM:116920]: LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions. {ECO:0000269|PubMed:1346613, ECO:0000269|PubMed:1347532, ECO:0000269|PubMed:1352501, ECO:0000269|PubMed:1590804, ECO:0000269|PubMed:1694220, ECO:0000269|PubMed:1968911, ECO:0000269|PubMed:20529581, ECO:0000269|PubMed:20549317, ECO:0000269|PubMed:7509236, ECO:0000269|PubMed:7686755, ECO:0000269|PubMed:9884339}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Integrin ITGAL:ITGB2 is a receptor for ICAM1, ICAM2 and ICAM3 (PubMed:1676048, PubMed:23775590, PubMed:38195629). Integrin ITGAL:ITGB2 is also a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Integrins ITGAM:ITGB2 and ITGAX:ITGB2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin ITGAX:ITGB2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin ITGAM:ITGB2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin ITGAM:ITGB2 is also a receptor for factor X. Integrin ITGAD:ITGB2 is a receptor for ICAM3 and VCAM1 (PubMed:10438935, PubMed:8777714, PubMed:9841932). Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992, PubMed:28807980). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin ITGAL:ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). In association with alpha subunit ITGAM/CD11b, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). Integrins ITGAX:ITGB2 functions as a receptor of the erythrocyte-specific adhesion molecule ICAM4 and mediates erythrophagocytosis (PubMed:16985175). Integrins ITGAX:ITGB2 functions as a receptor of the neuron-specific adhesion molecule ICAM5 ensuring neuron cell-leukocyte adhesion (PubMed:10741396). Integrin ITGAL:ITGB2 functions as a receptor of ICAM1 by acting as a platform at the immunological synapse to translate TCR engagement and density of the ITGAL ligand ICAM1 into graded adhesion (PubMed:38195629). Integrin ITGAM:ITGB2/MAC-1 complex functions as a signaling receptor for the ligand receptor ICAM1, ensuring adhesion between stimulated neutrophils and stimulated endothelial cells (PubMed:1980124). Integrin ITGAL/ITGB2 that functions as a signaling receptor of ICAM2, ensuring leukocyte cell-cell adhesion on resting cells (PubMed:1676048). {ECO:0000269|PubMed:10438935, ECO:0000269|PubMed:10741396, ECO:0000269|PubMed:11812992, ECO:0000269|PubMed:15356110, ECO:0000269|PubMed:1676048, ECO:0000269|PubMed:16985175, ECO:0000269|PubMed:18587400, ECO:0000269|PubMed:1980124, ECO:0000269|PubMed:21193407, ECO:0000269|PubMed:23775590, ECO:0000269|PubMed:28807980, ECO:0000269|PubMed:29100055, ECO:0000269|PubMed:38195629, ECO:0000269|PubMed:8777714, ECO:0000269|PubMed:9841932}.
uniprot
proteins
mass_dalton
84791
uniprot
proteins
mutagenesis
MUTAGEN 758; /note="T->A: Abolishes phosphorylation. Reduces COS cell adhesion to ICAM1."; /evidence="ECO:0000269|PubMed:16301335
uniprot
proteins
post_translational_modification
PTM: Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters (PubMed:11700305). Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins (PubMed:11700305, PubMed:16301335). {ECO:0000269|PubMed:11700305, ECO:0000269|PubMed:16301335}.
uniprot
proteins
protein_family
Integrin beta chain family
uniprot
proteins
pubmed
10438935
uniprot
proteins
pubmed
10741396
uniprot
proteins
pubmed
10766246
uniprot
proteins
pubmed
10830953
uniprot
proteins
pubmed
11700305
uniprot
proteins
pubmed
11812992
uniprot
proteins
pubmed
1346613
uniprot
proteins
pubmed
1347532
uniprot
proteins
pubmed
1352501
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14722085
uniprot
proteins
pubmed
15356110
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1590804
uniprot
proteins
pubmed
16301335
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
1675157
uniprot
proteins
pubmed
1676048
uniprot
proteins
pubmed
1683838
uniprot
proteins
pubmed
1694220
uniprot
proteins
pubmed
16985175
uniprot
proteins
pubmed
18587400
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
1968911
uniprot
proteins
pubmed
1980124
uniprot
proteins
pubmed
19828450
uniprot
proteins
pubmed
20033057
uniprot
proteins
pubmed
20529581
uniprot
proteins
pubmed
20549317
uniprot
proteins
pubmed
21193407
uniprot
proteins
pubmed
23775590
uniprot
proteins
pubmed
24385486
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26936951
uniprot
proteins
pubmed
27055590
uniprot
proteins
pubmed
28807980
uniprot
proteins
pubmed
29100055
uniprot
proteins
pubmed
2954816
uniprot
proteins
pubmed
3028646
uniprot
proteins
pubmed
38195629
uniprot
proteins
pubmed
7509236
uniprot
proteins
pubmed
7686755
uniprot
proteins
pubmed
8777714
uniprot
proteins
pubmed
9841932
uniprot
proteins
pubmed
9884339
uniprot
proteins
sequence_length
769
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16301335, ECO:0000269|PubMed:21193407, ECO:0000269|PubMed:28807980}; Single-pass type I membrane protein {ECO:0000305}. Membrane raft {ECO:0000269|PubMed:21193407}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 701..723; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins