P2rx2
entrez
114115
canonical
uniprot
P49653
canonical
ensembl
ENSRNOG00000037456
resolver
ensp
ENSRNOP00000053532
resolver
ensp
ENSRNOP00000053533
resolver
ensp
ENSRNOP00000074992
resolver
enst
ENSRNOT00000056694
resolver
enst
ENSRNOT00000085661
resolver
genesymbol
P2rx2
resolver
uniprot
A0A0G2K9G8
resolver
uniprot
A0A140TAH4
resolver
uniprot
O54868
resolver
uniprot_entry
A0A0G2K9G8_RAT
resolver
uniprot_entry
A0A140TAH4_RAT
resolver
uniprot_entry
P2RX2_RAT
resolver
uniprot_sec
O54868
resolver
activity_regulation
ACTIVITY REGULATION: Fast activation by external ATP (PubMed:10440098, PubMed:9119082). Exhibits slow desensitization during prolonged ATP activation (PubMed:10440098, PubMed:9119082). Not sensitive to the ATP agonist:alpha/beta-methylene-ATP (By similarity). {ECO:0000250|UniProtKB:Q9UBL9, ECO:0000269|PubMed:10440098, ECO:0000269|PubMed:9119082}.
uniprot
proteins
amino_acid_sequence
MVRRLARGCWSAFWDYETPKVIVVRNRRLGFVHRMVQLLILLYFVWYVFIVQKSYQDSETGPESSIITKVKGITMSEDKVWDVEEYVKPPEGGSVVSIITRIEVTPSQTLGTCPESMRVHSSTCHSDDDCIAGQLDMQGNGIRTGHCVPYYHGDSKTCEVSAWCPVEDGTSDNHFLGKMAPNFTILIKNSIHYPKFKFSKGNIASQKSDYLKHCTFDQDSDPYCPIFRLGFIVEKAGENFTELAHKGGVIGVIINWNCDLDLSESECNPKYSFRRLDPKYDPASSGYNFRFAKYYKINGTTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSIGVGSFLCDWILLTFMNKNKLYSHKKFDKVRTPKHPSSRWPVTLALVLGQIPPPPSHYSQDQPPSPPSGEGPTLGEGAELPLAVQSPRPCSISALTEQVVDTLGQHMGQRPPVPEPSQQDSTSTDPKGLAQL
uniprot
proteins
function
FUNCTION: ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (PubMed:10440098, PubMed:8961184, PubMed:9119082). Activation by extracellular ATP induces a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle (By similarity). {ECO:0000250|UniProtKB:Q9UBL9, ECO:0000269|PubMed:10440098, ECO:0000269|PubMed:8961184, ECO:0000269|PubMed:9119082}.
uniprot
proteins
mass_dalton
52617
uniprot
proteins
protein_family
P2X receptor family
uniprot
proteins
pubmed
10440098
uniprot
proteins
pubmed
11181939
uniprot
proteins
pubmed
12921863
uniprot
proteins
pubmed
15313628
uniprot
proteins
pubmed
17449665
uniprot
proteins
pubmed
7523952
uniprot
proteins
pubmed
7542879
uniprot
proteins
pubmed
8961184
uniprot
proteins
pubmed
9119082
uniprot
proteins
sequence_length
472
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15313628}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P56373}.
uniprot
proteins
transmembrane_region
TRANSMEM 35..52; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P56373"; TRANSMEM 327..347; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P56373
uniprot
proteins