Ms4a2
entrez
25316
canonical
uniprot
P13386
canonical
ensembl
ENSRNOG00000020993
resolver
ensp
ENSRNOP00000028491
resolver
genesymbol
Ms4a2
resolver
genesymbol_syn
Fce1b
resolver
genesymbol_syn
Fcer1b
resolver
uniprot_entry
FCERB_RAT
resolver
amino_acid_sequence
MDTENKSRADLALPNPQESPSAPDIELLEASPPAKALPEKPASPPPQQTWQSFLKKELEFLGVTQVLVGLICLCFGTVVCSTLQTSDFDDEVLLLYRAGYPFWGAVLFVLSGFLSIMSERKNTLYLVRGSLGANIVSSIAAGLGIAILILNLSNNSAYMNYCKDITEDDGCFVTSFITELVLMLLFLTILAFCSAVLLIIYRIGQEFERSKVPDDRLYEELHVYSPIYSALEDTREASAPVVS
uniprot
proteins
function
FUNCTION: High affinity receptor that binds to the Fc region of immunoglobulins epsilon. Aggregation of FCER1 by multivalent antigens is required for the full mast cell response, including the release of preformed mediators (such as histamine) by degranulation and de novo production of lipid mediators and cytokines. Also mediates the secretion of important lymphokines. Binding of allergen to receptor-bound IgE leads to cell activation and the release of mediators responsible for the manifestations of allergy.
uniprot
proteins
mass_dalton
26731
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues by LYN. {ECO:0000250}.
uniprot
proteins
protein_family
MS4A family
uniprot
proteins
pubmed
21746961
uniprot
proteins
pubmed
2970642
uniprot
proteins
sequence_length
243
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:21746961}; Multi-pass membrane protein {ECO:0000269|PubMed:21746961}.
uniprot
proteins
transmembrane_region
TRANSMEM 60..79; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 98..117; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 131..150; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 180..199; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins