PRKD3
entrez
23683
canonical
uniprot
O94806
canonical
ensembl
ENSG00000115825
resolver
ensp
ENSP00000234179
resolver
ensp
ENSP00000368356
resolver
ensp
ENSP00000755854
resolver
genesymbol
PRKD3
resolver
genesymbol_syn
EPK2
resolver
genesymbol_syn
PRKCN
resolver
hgnc
HGNC:9408
resolver
uniprot
D6W587
resolver
uniprot
Q53TR7
resolver
uniprot
Q8NEL8
resolver
uniprot_entry
KPCD3_HUMAN
resolver
uniprot_sec
D6W587
resolver
uniprot_sec
Q53TR7
resolver
uniprot_sec
Q8NEL8
resolver
activity_regulation
ACTIVITY REGULATION: Activated by DAG and phorbol esters. Phorbol-ester/DAG-type domains 1 and 2 bind both DAG and phorbol ester with high affinity and mediate translocation to the cell membrane. Autophosphorylation of Ser-735 and phosphorylation of Ser-731 by PKC relieves auto-inhibition by the PH domain. {ECO:0000269|PubMed:18076381}.
uniprot
proteins
amino_acid_sequence
MSANNSPPSAQKSVLPTAIPAVLPAASPCSSPKTGLSARLSNGSFSAPSLTNSRGSVHTVSFLLQIGLTRESVTIEAQELSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHDMNSENILQLITSADEIHEGDLVEVVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQPEYVALPSEESHVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPEDKMFFLDPSDLDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSPRDFTNISQGSNPHCFEIITDTMVYFVGENNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDHKDLSTSISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLREFETRIGERYITHESDDARWEIHAYTHNLVYPKHFIMAPNPDDMEEDP
uniprot
proteins
ec_number
2.7.11.13
uniprot
proteins
function
FUNCTION: Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
100471
uniprot
proteins
mutagenesis
MUTAGEN 156; /note="T->A: Slight loss in ability to bind DAG and phorbol-ester; when associated with F-158."; /evidence="ECO:0000269|PubMed:18076381"; MUTAGEN 158; /note="Y->F: Slight loss in ability to bind DAG and phorbol-ester; when associated with A-156."; /evidence="ECO:0000269|PubMed:18076381"; MUTAGEN 165; /note="P->G: No effect on ability to bind phorbol ester, loss of ability to bind DAG, reduced DAG-induced membrane translocation."; /evidence="ECO:0000269|PubMed:18076381"; MUTAGEN 166; /note="T->A: Slight loss in ability to bind DAG and phorbol-ester."; /evidence="ECO:0000269|PubMed:18076381"; MUTAGEN 170; /note="Y->F: Slight loss in ability to bind DAG and phorbol-ester."; /evidence="ECO:0000269|PubMed:18076381"; MUTAGEN 282; /note="P->G: No effect on ability to bind phorbol ester, increase in ability to bind DAG."; /evidence="ECO:0000269|PubMed:18076381"; MUTAGEN 284; /note="I->V: Slight increase in ability to bind DAG, no effect on phorbol-ester binding."; MUTAGEN 293; /note="K->W: Increased ability to bind DAG, no effect on phorbol-ester binding."; /evidence="ECO:0000269|PubMed:18076381
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
PKD subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10231560
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18076381
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
890
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18076381}. Membrane {ECO:0000269|PubMed:18076381}. Note=Translocation to the cell membrane is required for kinase activation.
uniprot
proteins