KCNIP3
entrez
30818
canonical
uniprot
Q9Y2W7
canonical
ensembl
ENSG00000115041
resolver
ensp
ENSP00000295225
resolver
ensp
ENSP00000417499
resolver
genesymbol
KCNIP3
resolver
genesymbol_syn
CSEN
resolver
genesymbol_syn
DREAM
resolver
genesymbol_syn
KCHIP3
resolver
hgnc
HGNC:15523
resolver
uniprot
H7BY46
resolver
uniprot
Q3YAC3
resolver
uniprot
Q3YAC4
resolver
uniprot
Q53TJ5
resolver
uniprot
Q96T40
resolver
uniprot
Q9UJ84
resolver
uniprot
Q9UJ85
resolver
uniprot_entry
CSEN_HUMAN
resolver
uniprot_sec
H7BY46
resolver
uniprot_sec
Q3YAC3
resolver
uniprot_sec
Q3YAC4
resolver
uniprot_sec
Q53TJ5
resolver
uniprot_sec
Q96T40
resolver
uniprot_sec
Q9UJ84
resolver
uniprot_sec
Q9UJ85
resolver
amino_acid_sequence
MQPAKEVTKASDGSLLGDLGHTPLSKKEGIKWQRPRLSRQALMRCCLVKWILSSTAPQGSDSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYAQFFPQGDATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLRGTVHEKLKWAFNLYDINKDGYITKEEMLAIMKSIYDMMGRHTYPILREDAPAEHVERFFEKMDRNQDGVVTIEEFLEACQKDENIMSSMQLFENVI
uniprot
proteins
function
FUNCTION: Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception (By similarity). {ECO:0000250|UniProtKB:Q9QXT8}.; FUNCTION: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. {ECO:0000269|PubMed:10676964, ECO:0000269|PubMed:12829703, ECO:0000269|PubMed:15485870, ECO:0000269|PubMed:16123112, ECO:0000269|PubMed:18957440}.; FUNCTION: May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation. {ECO:0000269|PubMed:11259376, ECO:0000269|PubMed:11988022, ECO:0000269|PubMed:9771752}.
uniprot
proteins
mass_dalton
29231
uniprot
proteins
mutagenesis
MUTAGEN 61; /note="D->A: Abolishes cleavage by caspase-3."; /evidence="ECO:0000269|PubMed:11278424"; MUTAGEN 64; /note="D->A: Abolishes cleavage by caspase-3."; /evidence="ECO:0000269|PubMed:11278424
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. Palmitoylation enhances association with the plasma membrane (By similarity). {ECO:0000250}.; PTM: Proteolytically cleaved by caspase-3. {ECO:0000269|PubMed:11278424}.; PTM: Phosphorylation at Ser-63 inhibits cleavage by CASP3. {ECO:0000269|PubMed:11278424, ECO:0000269|PubMed:12837631}.
uniprot
proteins
protein_family
Recoverin family
uniprot
proteins
pubmed
10078534
uniprot
proteins
pubmed
10676964
uniprot
proteins
pubmed
11259376
uniprot
proteins
pubmed
11278424
uniprot
proteins
pubmed
11988022
uniprot
proteins
pubmed
12829703
uniprot
proteins
pubmed
12837631
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14720210
uniprot
proteins
pubmed
15485870
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16112838
uniprot
proteins
pubmed
16123112
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17962406
uniprot
proteins
pubmed
18957440
uniprot
proteins
pubmed
21070824
uniprot
proteins
pubmed
9771752
uniprot
proteins
sequence_length
256
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18957440}. Cell membrane {ECO:0000269|PubMed:15485870, ECO:0000269|PubMed:18957440}; Lipid-anchor {ECO:0000250}. Endoplasmic reticulum {ECO:0000269|PubMed:11278424, ECO:0000269|PubMed:18957440}. Golgi apparatus {ECO:0000269|PubMed:11278424}. Nucleus {ECO:0000269|PubMed:21070824}. Note=Also membrane-bound, associated with the plasma membrane (PubMed:15485870). In the presence of PSEN2 associated with the endoplasmic reticulum and Golgi. The sumoylated form is present only in the nucleus. {ECO:0000269|PubMed:11278424, ECO:0000269|PubMed:15485870, ECO:0000269|PubMed:21070824}.
uniprot
proteins