Gfi1b
entrez
14582
canonical
uniprot
O70237
canonical
ensembl
ENSMUSG00000026815
resolver
ensp
ENSMUSP00000028156
resolver
ensp
ENSMUSP00000128052
resolver
enst
ENSMUST00000028156
resolver
enst
ENSMUST00000164290
resolver
genesymbol
Gfi1b
resolver
uniprot
B7ZNH2
resolver
uniprot
F6RLE8
resolver
uniprot
Q3U039
resolver
uniprot_entry
B7ZNH2_MOUSE
resolver
uniprot_entry
F6RLE8_MOUSE
resolver
uniprot_entry
GFI1B_MOUSE
resolver
uniprot_sec
Q3U039
resolver
amino_acid_sequence
MPRSFLVKSKKAHTYHQPRAQGDELVWPPAVIPVAKEHSQSASPLLSTPLPSQTLDWNTIKQEREMLLNQSLPKMASAPEGPLVTPQPQDGESPLSESPPFYKPSFSWDTLASSYSHSYTQTPSTMQSAFLERSVRLYGSPLVPSTESPLDFRLRYSPGMDTYHCVKCNKVFSTPHGLEVHVRRSHSGTRPFACDVCGKTFGHAVSLEQHTHVHSQERSFECRMCGKAFKRSSTLSTHLLIHSDTRPYPCQFCGKRFHQKSDMKKHTYIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFSCELCTKGFQRKVDLRRHRESQHNLK
uniprot
proteins
function
FUNCTION: Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling pathways. Cooperates with GATA1 to repress target gene transcription, such as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic cell lines markedly increase apoptosis rate. Inhibits down-regulation of MYC and MYB as well as the cyclin-dependent kinase inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells. Represses expression of GATA3 in T-cell lymphomas and inhibits GATA1-mediated transcription; as GATA1 also mediates erythroid GFI1B transcription, both GATA1 and GFI1B participate in a feedback regulatory pathway controlling the expression of GFI1B gene in erythroid cells. Suppresses GATA1-mediated stimulation of GFI1B promoter through protein interaction. Binds to gamma-satellite DNA and to its own promoter, auto-repressing its own expression. Alters histone methylation by recruiting histone methyltransferase to target genes promoters. Plays a role in heterochromatin formation. {ECO:0000269|PubMed:11696536, ECO:0000269|PubMed:12351384, ECO:0000269|PubMed:12594258, ECO:0000269|PubMed:15718298, ECO:0000269|PubMed:17707228, ECO:0000269|PubMed:9566867}.
uniprot
proteins
mass_dalton
37443
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="P->A: Abrogates interaction with NCOR1 and KDM1A. Greatly diminished interaction with HDAC2. Loss of ability to promote erythrocyte and granulocyte differentiation."; /evidence="ECO:0000269|PubMed:17707228
uniprot
proteins
post_translational_modification
PTM: Methylation at Lys-8 in the SNAG domain seems required for the recruitment of the corepressor complex. {ECO:0000250}.
uniprot
proteins
pubmed
11696536
uniprot
proteins
pubmed
11825872
uniprot
proteins
pubmed
12351384
uniprot
proteins
pubmed
12594258
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15718298
uniprot
proteins
pubmed
15920471
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17095621
uniprot
proteins
pubmed
17707228
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9566867
uniprot
proteins
sequence_length
330
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12594258}. Note=Localized at foci of pericentric heterochromatin.
uniprot
proteins