Slc51b
entrez
330962
canonical
uniprot
Q80WK2
canonical
ensembl
ENSMUSG00000053862
resolver
ensp
ENSMUSP00000064494
resolver
enst
ENSMUST00000065894
resolver
genesymbol
Slc51b
resolver
genesymbol_syn
Ostb
resolver
uniprot
Q14BU3
resolver
uniprot
Q3V4C1
resolver
uniprot_entry
OSTB_MOUSE
resolver
uniprot_sec
Q14BU3
resolver
uniprot_sec
Q3V4C1
resolver
amino_acid_sequence
MDHSAEKAAANAEVPQELLEEMLWYFRAEDAAPWNYSILVLAVLVVMTSMFLLRRSILANRNRKKQPQDKETPEDLHLDDSIMKENNSQVFLRETLISEKPDLAPGEPELKEKDSSLVFLPDPQETES
uniprot
proteins
function
FUNCTION: Essential component of the OST-alpha/OST-beta complex, a heterotetramer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood (PubMed:15563450, PubMed:16317684, PubMed:17650074, PubMed:22535958). The OST-alpha/OST-beta complex efficiently transports the major species of bile acids (taurocholate) (PubMed:16317684, PubMed:17650074, PubMed:22535958). Taurine conjugates are transported more efficiently across the basolateral membrane than glycine-conjugated bile acids (PubMed:16317684). In the complex, SLC51B/OST-beta promotes the transmembrane translocation of bile acids (By similarity). Can also transport steroids such as estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, therefore playing a role in the enterohepatic circulation of sterols (By similarity). Able to transport eicosanoids such as prostaglandin E2 (By similarity). {ECO:0000250|UniProtKB:Q86UW2, ECO:0000250|UniProtKB:Q90YM4, ECO:0000269|PubMed:15563450, ECO:0000269|PubMed:16317684, ECO:0000269|PubMed:17650074, ECO:0000269|PubMed:22535958}.
uniprot
proteins
mass_dalton
14684
uniprot
proteins
mutagenesis
MUTAGEN 29..30; /note="ED->AA: Does not inhibit transport activity. Does not inhibit colocalization with SLC51A at the plasma membrane. Does not decrease glycosylation of SLC51A."; /evidence="ECO:0000269|PubMed:22535958"; MUTAGEN 34..35; /note="WN->AA: Inhibits transport activity. Inhibits weakly colocalization with SLC51A at the plasma membrane. Decreases glycosylation of SLC51A."; /evidence="ECO:0000269|PubMed:22535958"; MUTAGEN 34..35; /note="WN->FQ: Does not inhibit transport activity. Does not inhibit colocalization with SLC51A at the plasma membrane. Does not decrease glycosylation of SLC51A."; /evidence="ECO:0000269|PubMed:22535958"; MUTAGEN 54..55; /note="RR->AA: Inhibits transport activity. Inhibits localization at the plasma membrane and membrane orientation. Decreases glycosylation of SLC51A."; /evidence="ECO:0000269|PubMed:22535958"; MUTAGEN 61; /note="R->G: Does not inhibit transport activity. Does not inhibit colocalization with SLC51A at the plasma membrane."; /evidence="ECO:0000269|PubMed:22535958
uniprot
proteins
protein_family
OST-beta family
uniprot
proteins
pubmed
12719432
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15563450
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16317684
uniprot
proteins
pubmed
16357058
uniprot
proteins
pubmed
16628672
uniprot
proteins
pubmed
17650074
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22535958
uniprot
proteins
sequence_length
128
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:15563450, ECO:0000269|PubMed:17650074, ECO:0000269|PubMed:22535958}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q86UW2}. Note=Mainly restricted to the lateral and basal membranes of ileal enterocytes. {ECO:0000250|UniProtKB:Q86UW2}.
uniprot
proteins
transmembrane_region
TRANSMEM 33..60; /note="Helical; Name=TM0"; /evidence="ECO:0000250|UniProtKB:Q86UW2
uniprot
proteins