Kcnt1
entrez
227632
canonical
uniprot
Q6ZPR4
canonical
ensembl
ENSMUSG00000058740
resolver
ensp
ENSMUSP00000039058
resolver
ensp
ENSMUSP00000109809
resolver
ensp
ENSMUSP00000109813
resolver
ensp
ENSMUSP00000132212
resolver
ensp
ENSMUSP00000142870
resolver
ensp
ENSMUSP00000143106
resolver
ensp
ENSMUSP00000143482
resolver
ensp
ENSMUSP00000192621
resolver
ensp
ENSMUSP00000192624
resolver
ensp
ENSMUSP00000192625
resolver
ensp
ENSMUSP00000192628
resolver
ensp
ENSMUSP00000192634
resolver
enst
ENSMUST00000037580
resolver
enst
ENSMUST00000114176
resolver
enst
ENSMUST00000197917
resolver
enst
ENSMUST00000198204
resolver
genesymbol
Kcnt1
resolver
genesymbol_syn
Kiaa1422
resolver
genesymbol_syn
Slack
resolver
genesymbol_syn
Slo2.2
resolver
uniprot
A0A0G2JER3
resolver
uniprot
A2AHB7
resolver
uniprot
A2AHB8
resolver
uniprot
A2AHB9
resolver
uniprot
B2RUK3
resolver
uniprot
C0KTP6
resolver
uniprot
Q8C3E7
resolver
uniprot
Q8C853
resolver
uniprot_entry
A0A0G2JER3_MOUSE
resolver
uniprot_entry
A2AHB7_MOUSE
resolver
uniprot_entry
A2AHB8_MOUSE
resolver
uniprot_entry
A2AHB9_MOUSE
resolver
uniprot_entry
KCNT1_MOUSE
resolver
uniprot_entry
Q8C853_MOUSE
resolver
uniprot_sec
B2RUK3
resolver
uniprot_sec
C0KTP6
resolver
uniprot_sec
Q8C3E7
resolver
activity_regulation
ACTIVITY REGULATION: Activated by high intracellular Na(+) (By similarity). In addition to activation by Na(+), is cooperatively activated by intracellular Cl(-) levels (By similarity). Inhibited by Zn(2+) (By similarity). Activated upon stimulation of G protein-coupled receptors, such as CHRM1 and GRIA1 (By similarity). {ECO:0000250|UniProtKB:Q5JUK3, ECO:0000250|UniProtKB:Q9Z258}.
uniprot
proteins
amino_acid_sequence
MARAKLPRSPSEGKAGPGDTPAGAAAPEEPHGLSPLLPARGGGSVGSDVGQRVQVEFYVNENTFKERLKLFFIKNQRSSLRIRLFNFSLKLLTCLLYIVRVLLDNPDQGIGCWGCTKYNYTFNGSSSEFHWAPILWVERKMALWVIQVIVATISFLETMLIIYLSYKGNIWEQIFHVSFVLEMINTLPFIITVFWPPLRNLFIPVFLNCWLAKHALENMINDFHRAILRTQSAMFNQVLILFCTLLCLVFTGTCGIQHLERAGGNLNLLTSFYFCIVTFSTVGFGDVTPKIWPSQLLVVILICVTLVVLPLQFEELVYLWMERQKSGGNYSRHRARTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPSEMDVQVRRVLQIPLWSQRVIYLQGSALKDQDLMRAKMDNGEACFILSSRNEVDRTAADHQTILRAWAVKDFAPNCPLYVQILKPENKFHVKFADHVVCEEECKYAMLALNCICPATSTLITLLVHTSRGQEGQESPEQWQRTYGRCSGNEVYHIRMGDSKFFREYEGKSFTYAAFHAHKKYGVCLIGLKREENKSILLNPGPRHILAASDTCFYINITKEENSAFIFKQEEKQKRRGLAGQALYEGPSRLPVHSIIASMGTVAMDLQNTDCRPSQGGSGGDGTKLTLPTENGSGSRRPSIAPVLELADSSALLPCDLLSDQSEDEVTPSDDEGLSVVEYVKGYPPNSPYIGSSPTLCHLLPVKAPFCCLRLDKGCKHNSYEDAKAYGFKNKLIIVSAETAGNGLYNFIVPLRAYYRSRRELNPIVLLLDNKPDHHFLEAICCFPMVYYMEGSVDNLDSLLQCGIIYADNLVVVDKESTMSAEEDYMADAKTIVNVQTMFRLFPSLSITTELTHPSNMRFMQFRAKDSYSLALSKLEKQERENGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMITITRLLLGLDTTPGSGYLCAMKVTEDDLWIRTYGRLFQKLCSSSAEIPIGIYRTECHVFSEPHDVRAQSQISVNMEDCEDTREAKGPWGTRAASGSGSTHGRHGGSADPVEHPLLRRKSLQWARKLSRKSTKQAGKAPVATDWITQQRLSLYRRSERQELSELVKNRMKHLGLPTTGYEDVANLTASDVMNRVNLGYLQDEMNDHHQNTLSYVLINPPPDTRLEPNDIVYLIRSDPLAHVASSSQSRKSSCSNKLSSCNPETRDETQL
uniprot
proteins
function
FUNCTION: Sodium-activated K(+) channel (PubMed:26559620). Acts as an important mediator of neuronal membrane excitability (By similarity). Contributes to the delayed outward currents (By similarity). Regulates neuronal bursting in sensory neurons (PubMed:25609627, PubMed:26559620). Contributes to synaptic development and plasticity (PubMed:32081855, PubMed:34664085). {ECO:0000250|UniProtKB:Q5JUK3, ECO:0000250|UniProtKB:Q9Z258, ECO:0000269|PubMed:25609627, ECO:0000269|PubMed:26559620, ECO:0000269|PubMed:32081855, ECO:0000269|PubMed:34664085}.
uniprot
proteins
mass_dalton
138106
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain increases channel activity. {ECO:0000250|UniProtKB:Q9Z258}.
uniprot
proteins
protein_family
Calcium-activated (TC 1.A.1.3) subfamily
uniprot
proteins
protein_family
KCa4.1/KCNT1 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18787033
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20512134
uniprot
proteins
pubmed
25609627
uniprot
proteins
pubmed
26559620
uniprot
proteins
pubmed
29124216
uniprot
proteins
pubmed
32081855
uniprot
proteins
pubmed
34664085
uniprot
proteins
sequence_length
1224
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29124216}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5JUK3}.
uniprot
proteins
transmembrane_region
TRANSMEM 80..112; /note="Helical; Name=Segment S1"; /evidence="ECO:0000250|UniProtKB:Q5JUK3"; TRANSMEM 140..164; /note="Helical; Name=Segment S2"; /evidence="ECO:0000250|UniProtKB:Q5JUK3"; TRANSMEM 179..194; /note="Helical; Name=Segment S3"; /evidence="ECO:0000250|UniProtKB:Q5JUK3"; TRANSMEM 202..219; /note="Helical; Name=Segment S4"; /evidence="ECO:0000250|UniProtKB:Q5JUK3"; TRANSMEM 233..260; /note="Helical; Name=Segment S5"; /evidence="ECO:0000250|UniProtKB:Q5JUK3"; TRANSMEM 291..324; /note="Helical; Name=Segment S6"; /evidence="ECO:0000250|UniProtKB:Q5JUK3
uniprot
proteins