TRIM45
entrez
80263
canonical
uniprot
Q9H8W5
canonical
ensembl
ENSG00000134253
resolver
ensp
ENSP00000256649
resolver
ensp
ENSP00000358473
resolver
ensp
ENSP00000358476
resolver
genesymbol
TRIM45
resolver
genesymbol_syn
RNF99
resolver
hgnc
HGNC:19018
resolver
uniprot
Q53GN0
resolver
uniprot
Q5T2K4
resolver
uniprot
Q5T2K5
resolver
uniprot
Q8IYV6
resolver
uniprot_entry
TRI45_HUMAN
resolver
uniprot_sec
Q53GN0
resolver
uniprot_sec
Q5T2K4
resolver
uniprot_sec
Q5T2K5
resolver
uniprot_sec
Q8IYV6
resolver
amino_acid_sequence
MSENRKPLLGFVSKLTSGTALGNSGKTHCPLCLGLFKAPRLLPCLHTVCTTCLEQLEPFSVVDIRGGDSDTSSEGSIFQELKPRSLQSQIGILCPVCDAQVDLPMGGVKALTIDHLAVNDVMLESLRGEGQGLVCDLCNDREVEKRCQTCKANLCHFCCQAHRRQKKTTYHTMVDLKDLKGYSRIGKPILCPVHPAEELRLFCEFCDRPVCQDCVVGEHREHPCDFTSNVIHKHGDSVWELLKGTQPHVEALEEALAQIHIINSALQKRVEAVAADVRTFSEGYIKAIEEHRDKLLKQLEDIRAQKENSLQLQKAQLEQLLADMRTGVEFTEHLLTSGSDLEILITKRVVVERLRKLNKVQYSTRPGVNDKIRFCPQEKAGQCRGYEIYGTINTKEVDPAKCVLQGEDLHRAREKQTASFTLLCKDAAGEIMGRGGDNVQVAVVPKDKKDSPVRTMVQDNKDGTYYISYTPKEPGVYTVWVCIKEQHVQGSPFTVMVRRKHRPHSGVFHCCTFCSSGGQKTARCACGGTMPGGYLGCGHGHKGHPGHPHWSCCGKFNEKSECTWTGGQSAPRSLLRTVAL
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that plays a role in the regulation of inflammatory response (PubMed:36681779). Mechanistically, mediates the 'Lys-48'-linked polyubiquitination of TAB2, a regulatory protein of the kinase TAK1, leading to its degradation via the proteasomal pathway and inhibition of the TLR-mediated inflammatory immune response (PubMed:36681779). May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway. {ECO:0000269|PubMed:15351693, ECO:0000269|PubMed:36681779}.
uniprot
proteins
mass_dalton
64359
uniprot
proteins
mutagenesis
MUTAGEN 94; /note="C->A: Loss of ubiquitination activity; when associated with A-97."; /evidence="ECO:0000269|PubMed:36681779"; MUTAGEN 97; /note="C->A: Loss of ubiquitination activity; when associated with A-94."; /evidence="ECO:0000269|PubMed:36681779
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15351693
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
36681779
uniprot
proteins
sequence_length
580
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15351693, ECO:0000269|PubMed:36681779}. Nucleus {ECO:0000269|PubMed:15351693}.
uniprot
proteins