Arid3a
entrez
13496
canonical
uniprot
Q62431
canonical
ensembl
ENSMUSG00000019564
resolver
ensp
ENSMUSP00000019708
resolver
ensp
ENSMUSP00000101015
resolver
ensp
ENSMUSP00000101016
resolver
enst
ENSMUST00000019708
resolver
enst
ENSMUST00000105376
resolver
enst
ENSMUST00000105377
resolver
genesymbol
Arid3a
resolver
genesymbol_syn
Dri1
resolver
genesymbol_syn
Dril1
resolver
uniprot
A0A0R4J1A7
resolver
uniprot
Q3U338
resolver
uniprot
Q80YP8
resolver
uniprot_entry
A0A0R4J1A7_MOUSE
resolver
uniprot_entry
ARI3A_MOUSE
resolver
uniprot_sec
Q3U338
resolver
uniprot_sec
Q80YP8
resolver
amino_acid_sequence
MKLQAVMETLIQRQQRARQELEARQAPPPPPPEPTGVRARTTMTDEDREPENARMHRTQMAALAAMRAAAAGLGHPSSPGGSEDGPPISGDEDTAREGTLSSPALHGSVLEGAGHAEGDRHLMDVGSDDDDTKSKWEEQELEELGEEEEEEEEEDDFEEEEEEEEGLGPPESASLGTAGLFTRKAPPAQAFRGDGGPRMLSGPERLGPGPAHPSHMASQMPPPDHGDWTFEEQFKQLYELDADPKRKEFLDDLFSFMQKRGTPVNRIPIMAKQVLDLFMLYVLVTEKGGLVEVINKKLWREITKGLNLPTSITSAAFTLRTQYMKYLYPYECERRGLSSPNELQAAIDSNRREGRRQSFGGSLFAYSPSGAHSMLPSPKLPVTPLGLAASTNGSSITPAPKIKKEEDSAIPITVPGRLPVSLAGHPVVAAQAAAVQAAAAQAAVAAQAAALEQLREKLESTEPPEKKMALVADEQQRLMQRAVQQSFLAMTAQLPMNIRINSQASESRQDSAVSLTSANGSNSISMSVEMNGIVYTGVLFAQPPPPTAPSAPGKGGVSSIGTNTTTGSRTGASGSTVSGGQVGLPGVSTPTMSSTSNNSLP
uniprot
proteins
function
FUNCTION: Transcription factor involved in B-cell differentiation. Binds a VH promoter proximal site necessary for induced mu-heavy-chain transcription. Binds the minor groove of a restricted ATC sequence that is sufficient for nuclear matrix association. This sequence motif is present in matrix-associating regions (MARS) proximal to the promoter and flanking E mu. Activates E mu-driven transcription by binding these sites. May be involved in the control of cell cycle progression by the RB1/E2F1 pathway. {ECO:0000269|PubMed:11294836, ECO:0000269|PubMed:17312145, ECO:0000269|PubMed:8543152}.
uniprot
proteins
mass_dalton
64173
uniprot
proteins
mutagenesis
MUTAGEN 268; /note="P->A: Impairs DNA-binding."; /evidence="ECO:0000269|PubMed:15456761"; MUTAGEN 299; /note="W->A: Impairs DNA-binding."; /evidence="ECO:0000269|PubMed:15456761"; MUTAGEN 317; /note="F->A: Impairs DNA-binding."; /evidence="ECO:0000269|PubMed:15456761"; MUTAGEN 330; /note="Y->A: Impairs DNA-binding."; /evidence="ECO:0000269|PubMed:15456761"; MUTAGEN 457; /note="K->A: No effect on cellular location."; /evidence="ECO:0000269|PubMed:16507996"; MUTAGEN 463; /note="P->A: Abolishes nuclear localization."; /evidence="ECO:0000269|PubMed:16507996"; MUTAGEN 466; /note="K->A: Abolishes nuclear localization."; /evidence="ECO:0000269|PubMed:16507996"; MUTAGEN 467; /note="K->A: Abolishes nuclear localization."; /evidence="ECO:0000269|PubMed:16507996"; MUTAGEN 532; /note="G->A: Abolishes cytosolic localization."; /evidence="ECO:0000269|PubMed:16507996"; MUTAGEN 535; /note="Y->A: Abolishes cytosolic localization."; /evidence="ECO:0000269|PubMed:16507996"; MUTAGEN 535; /note="Y->F: No effect on cellular location."; /evidence="ECO:0000269|PubMed:16507996"; MUTAGEN 537; /note="G->A: Abolishes cytosolic localization."; /evidence="ECO:0000269|PubMed:16507996"; MUTAGEN 539; /note="L->A: Abolishes cytosolic localization."; /evidence="ECO:0000269|PubMed:16507996
uniprot
proteins
pubmed
11120822
uniprot
proteins
pubmed
11294836
uniprot
proteins
pubmed
15456761
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16507996
uniprot
proteins
pubmed
16738337
uniprot
proteins
pubmed
17312145
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8543152
uniprot
proteins
pubmed
9590220
uniprot
proteins
sequence_length
601
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Shuttles between nucleus and cytoplasm.
uniprot
proteins