SDE2
entrez
163859
canonical
uniprot
Q6IQ49
canonical
ensembl
ENSG00000143751
resolver
ensp
ENSP00000272091
resolver
genesymbol
SDE2
resolver
genesymbol_syn
C1orf55
resolver
hgnc
HGNC:26643
resolver
uniprot
A8K4P3
resolver
uniprot
Q5TD36
resolver
uniprot
Q6ZS26
resolver
uniprot
Q8NAG7
resolver
uniprot_entry
SDE2_HUMAN
resolver
uniprot_sec
A8K4P3
resolver
uniprot_sec
Q5TD36
resolver
uniprot_sec
Q6ZS26
resolver
uniprot_sec
Q8NAG7
resolver
amino_acid_sequence
MAEAAALVWIRGPGFGCKAVRCASGRCTVRDFIHRHCQDQNVPVENFFVKCNGALINTSDTVQHGAVYSLEPRLCGGKGGFGSMLRALGAQIEKTTNREACRDLSGRRLRDVNHEKAMAEWVKQQAEREAEKEQKRLERLQRKLVEPKHCFTSPDYQQQCHEMAERLEDSVLKGMQAASSKMVSAEISENRKRQWPTKSQTDRGASAGKRRCFWLGMEGLETAEGSNSESSDDDSEEAPSTSGMGFHAPKIGSNGVEMAAKFPSGSQRARVVNTDHGSPEQLQIPVTDSGRHILEDSCAELGESKEHMESRMVTETEETQEKKAESKEPIEEEPTGAGLNKDKETEERTDGERVAEVAPEERENVAVAKLQESQPGNAVIDKETIDLLAFTSVAELELLGLEKLKCELMALGLKCGGTLQERAARLFSVRGLAKEQIDPALFAKPLKGKKK
uniprot
proteins
function
FUNCTION: Inhibits translesion DNA synthesis by preventing monoubiquitination of PCNA, this is necessary to counteract damage due to ultraviolet light-induced replication stress (PubMed:27906959). SDE2 is cleaved following PCNA binding, and its complete degradation is necessary to allow S-phase progression following DNA damage (PubMed:27906959). {ECO:0000269|PubMed:27906959}.; FUNCTION: Plays a role in pre-mRNA splicing by facilitating excision of relatively short introns featuring weak 3'-splice sites (ss) and high GC content (PubMed:34365507). May recruit CACTIN to the spliceosome (By similarity). {ECO:0000250|UniProtKB:O14113, ECO:0000269|PubMed:34365507}.; FUNCTION: Plays a role in ribosome biogenesis by enabling SNORD3- and SNORD118-dependent cleavage of the 47S rRNA precursor (PubMed:34365507). Binds ncRNA (non-coding RNA) including the snoRNAs SNORD3 and SNORD118 (PubMed:34365507). {ECO:0000269|PubMed:34365507}.
uniprot
proteins
mass_dalton
49742
uniprot
proteins
mutagenesis
MUTAGEN 47..48; /note="FF->AA: No binding to PCNA; no cleavage at Gly-77."; /evidence="ECO:0000269|PubMed:27906959"; MUTAGEN 76..77; /note="GG->AA: No cleavage at Gly-77."; /evidence="ECO:0000269|PubMed:27906959, ECO:0000269|PubMed:28947618"; MUTAGEN 78; /note="K->A: No effect on cleavage at Gly-77."; /evidence="ECO:0000269|PubMed:28947618
uniprot
proteins
post_translational_modification
PTM: Upon binding to PCNA, the N-terminal UBL (ubiquitin-like) propeptide is cleaved at Gly-77 by an unidentified deubiquitinating enzyme; the resulting mature SDE2 is degraded by the DCX(DTL) complex in a cell cycle- and DNA damage dependent manner. {ECO:0000269|PubMed:27906959, ECO:0000269|PubMed:28947618}.; PTM: Both SDE2-UBL and the mature SDE2 are polyubiquitinated. {ECO:0000269|PubMed:27906959}.
uniprot
proteins
protein_family
SDE2 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27906959
uniprot
proteins
pubmed
28947618
uniprot
proteins
pubmed
34365507
uniprot
proteins
sequence_length
451
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27906959, ECO:0000269|PubMed:34365507}. Cytoplasm {ECO:0000269|PubMed:34365507}.
uniprot
proteins