Gnas
entrez
24896
canonical
uniprot
P63095
canonical
uniprot
Q792G6
canonical
ensembl
ENSRNOG00000047374
resolver
ensembl
ENSRNOG00000080265
resolver
ensembl
ENSRNOG00055001007
resolver
ensembl
ENSRNOG00055001386
resolver
ensembl
ENSRNOG00060001165
resolver
ensembl
ENSRNOG00065013234
resolver
ensp
ENSRNOP00000033065
resolver
ensp
ENSRNOP00000080642
resolver
ensp
ENSRNOP00000088089
resolver
ensp
ENSRNOP00000094944
resolver
enst
ENSRNOT00000035916
resolver
enst
ENSRNOT00000095590
resolver
enst
ENSRNOT00000112766
resolver
genesymbol
Gnas
resolver
genesymbol_syn
Gnas1
resolver
uniprot
A0A8I6A4D8
resolver
uniprot
A0A8I6AN29
resolver
uniprot
B0BMW4
resolver
uniprot
B4F771
resolver
uniprot
G3V916
resolver
uniprot
P04894
resolver
uniprot
P08755
resolver
uniprot
Q05087
resolver
uniprot
Q45QM7
resolver
uniprot
Q9Z1R8
resolver
uniprot_entry
A0A8I6A4D8_RAT
resolver
uniprot_entry
A0A8I6AN29_RAT
resolver
uniprot_entry
B0BMW4_RAT
resolver
uniprot_entry
B4F771_RAT
resolver
uniprot_entry
G3V916_RAT
resolver
uniprot_entry
GNAS2_RAT
resolver
uniprot_entry
GNAS3_RAT
resolver
uniprot_sec
P04894
resolver
uniprot_sec
P08755
resolver
uniprot_sec
Q05087
resolver
uniprot_sec
Q45QM7
resolver
uniprot_sec
Q9Z1R8
resolver
amino_acid_sequence
MDRRSRAHQWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALASSNARAQQRAAQRRSFLNAHHRSAAAAAAAQVLPESSESESDHEHEEAEPELARPECLEYDQDDYETETDSETEPESDIQSETEFETEPETEPETAPTTEPETEPEDERGPRGATFNQSLTQRLHALKLQSADASPRRAQPTTQEPESASEGEEPQREPLDEDPRDPEESEERREANRQPRRCKTRRPARRRDQSPESPPRKGPIPIRRH
uniprot
proteins
amino_acid_sequence
MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPNFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. Functions downstream of beta-adrenergic receptors. Stimulates the Ras signaling pathway via RAPGEF2. {ECO:0000250|UniProtKB:P63092}.
uniprot
proteins
mass_dalton
29219
uniprot
proteins
mass_dalton
45664
uniprot
proteins
mutagenesis
MUTAGEN 3; /note="C->A: Abolishes S-palmitoylation."; /evidence="ECO:0000269|PubMed:8347607"; MUTAGEN 201; /note="R->C: Translocated from plasma membrane to cytoplasm."; /evidence="ECO:0000269|PubMed:8856666
uniprot
proteins
post_translational_modification
PTM: Binds keratan sulfate chains. {ECO:0000250|UniProtKB:O18979}.; PTM: May be proteolytically processed to give rise to a number of active peptides. {ECO:0000269|PubMed:10729789}.
uniprot
proteins
protein_family
G(s) subfamily
uniprot
proteins
protein_family
G-alpha family
uniprot
proteins
protein_family
NESP55 family
uniprot
proteins
pubmed
10729789
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2820999
uniprot
proteins
pubmed
3086867
uniprot
proteins
pubmed
38168118
uniprot
proteins
pubmed
7500342
uniprot
proteins
pubmed
8347607
uniprot
proteins
pubmed
8486667
uniprot
proteins
pubmed
8856666
uniprot
proteins
sequence_length
256
uniprot
proteins
sequence_length
394
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8856666}; Peripheral membrane protein {ECO:0000269|PubMed:8856666}; Cytoplasmic side {ECO:0000269|PubMed:8856666}. Note=Associated to the plasma membrane via lipid-anchor. {ECO:0000269|PubMed:8856666}.
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250}. Secreted {ECO:0000250}. Note=Neuroendocrine secretory granules. {ECO:0000250}.
uniprot
proteins