Hoxa9
entrez
15405
canonical
uniprot
P09631
canonical
ensembl
ENSMUSG00000038227
resolver
ensp
ENSMUSP00000046939
resolver
genesymbol
Hoxa9
resolver
genesymbol_syn
Hox-1.7
resolver
genesymbol_syn
Hoxa-9
resolver
uniprot
O70154
resolver
uniprot
O70155
resolver
uniprot_entry
HXA9_MOUSE
resolver
uniprot_sec
O70154
resolver
uniprot_sec
O70155
resolver
amino_acid_sequence
MATTGALGNYYVDSFLLGADAADELGAGRYAPGTLGQPPRQAAALAEHPDFSPCSFQSKAAVFGASWNPVHAAGANAVPAAVYHHHHHPYVHPQAPVAAAAPDGRYMRSWLEPTPGALSFAGLPSSRPYGIKPEPLSARRGDCPTLDTHTLSLTDYACGSPPVDREKQPSEGAFSENNAENESGGDKPPIDPNNPAANWLHARSTRKKRCPYTKHQTLELEKEFLFNMYLTRDRRYEVARLLNLTERQVKIWFQNRRMKMKKINKDRAKDE
uniprot
proteins
function
FUNCTION: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of SELE/E-selectin and VCAM1 on the endothelial cell surface at sites of inflammation (By similarity). Positively regulates EIF4E-mediated mRNA nuclear export and also increases the translation efficiency of ODC mRNA in the cytoplasm by competing with factors which repress EIF4E activity such as PRH (PubMed:15657436). {ECO:0000250|UniProtKB:P31269, ECO:0000269|PubMed:15657436}.
uniprot
proteins
mass_dalton
29917
uniprot
proteins
mutagenesis
MUTAGEN 11; /note="Y->A: Significant reduction in interaction with EIF4E."; /evidence="ECO:0000269|PubMed:15657436
uniprot
proteins
post_translational_modification
PTM: Methylated on Arg-140 by PRMT5; methylation is critical for E-selectin induction. {ECO:0000250}.
uniprot
proteins
protein_family
Abd-B homeobox family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15657436
uniprot
proteins
pubmed
2891029
uniprot
proteins
pubmed
9524228
uniprot
proteins
sequence_length
271
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P31269}. Cytoplasm {ECO:0000250|UniProtKB:P31269}.
uniprot
proteins