P2RX2
entrez
22953
canonical
uniprot
Q9UBL9
canonical
ensembl
ENSG00000187848
resolver
ensp
ENSP00000341419
resolver
ensp
ENSP00000343339
resolver
ensp
ENSP00000343904
resolver
ensp
ENSP00000344502
resolver
ensp
ENSP00000345095
resolver
ensp
ENSP00000405531
resolver
ensp
ENSP00000444477
resolver
ensp
ENSP00000494644
resolver
enst
ENST00000542301
resolver
genesymbol
P2RX2
resolver
genesymbol_syn
P2X2
resolver
hgnc
HGNC:15459
resolver
uniprot
A0ACM8Q8Y1
resolver
uniprot
A6NGB4
resolver
uniprot
A6NH93
resolver
uniprot
A6NHC2
resolver
uniprot
A6NHU3
resolver
uniprot
A6NIG9
resolver
uniprot
H0YGR7
resolver
uniprot
Q32MC3
resolver
uniprot
Q6V9R6
resolver
uniprot
Q9NR37
resolver
uniprot
Q9NR38
resolver
uniprot
Q9UHD5
resolver
uniprot
Q9UHD6
resolver
uniprot
Q9UHD7
resolver
uniprot
Q9Y637
resolver
uniprot
Q9Y638
resolver
uniprot_entry
A0ACM8Q8Y1_HUMAN
resolver
uniprot_entry
P2RX2_HUMAN
resolver
uniprot_entry
Q32MC3_HUMAN
resolver
uniprot_sec
A6NGB4
resolver
uniprot_sec
A6NH93
resolver
uniprot_sec
A6NHC2
resolver
uniprot_sec
A6NHU3
resolver
uniprot_sec
A6NIG9
resolver
uniprot_sec
H0YGR7
resolver
uniprot_sec
Q6V9R6
resolver
uniprot_sec
Q9NR37
resolver
uniprot_sec
Q9NR38
resolver
uniprot_sec
Q9UHD5
resolver
uniprot_sec
Q9UHD6
resolver
uniprot_sec
Q9UHD7
resolver
uniprot_sec
Q9Y637
resolver
uniprot_sec
Q9Y638
resolver
activity_regulation
ACTIVITY REGULATION: Fast activation by external ATP (PubMed:10570044, PubMed:31636190). Exhibits slow desensitization during prolonged ATP activation (By similarity). Not sensitive to the ATP agonist:alpha/beta-methylene-ATP (PubMed:10570044). {ECO:0000250|UniProtKB:P49653, ECO:0000269|PubMed:10570044, ECO:0000269|PubMed:31636190}.
uniprot
proteins
amino_acid_sequence
MAAAQPKYPAGATARRLARGCWSALWDYETPKVIVVRNRRLGVLYRAVQLLILLYFVWYVFIVQKSYQESETGPESSIITKVKGITTSEHKVWDVEEYVKPPEGGSVFSIITRVEATHSQTQGTCPESIRVHNATCLSDADCVAGELDMLGNGLRTGRCVPYYQGPSKTCEVFGWCPVEDGASVSQFLGTMAPNFTILIKNSIHYPKFHFSKGNIADRTDGYLKRCTFHEASDLYCPIFKLGFIVEKAGESFTELAHKGGVIGVIINWDCDLDLPASECNPKYSFRRLDPKHVPASSGYNFRFAKYYKINGTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSVGVGSFLCDWILLTFMNKNKVYSHKKFDKVCTPSHPSGSWPVTLARVLGQAPPEPGHRSEDQHPSPPSGQEGQQGAECGPAFPPLRPCPISAPSEQMVDTPASEPAQASTPTDPKGLAQL
uniprot
proteins
disease_involvement
DISEASE: Deafness, autosomal dominant, 41 (DFNA41) [MIM:608224]: A form of non-syndromic deafness characterized by onset of progressive sensorineural hearing loss usually in the second decade. The hearing loss is severe and ultimately affects all frequencies. Exposure to noise exacerbates the hearing loss, particularly at high frequencies. {ECO:0000269|PubMed:23345450, ECO:0000269|PubMed:24211385, ECO:0000269|PubMed:31636190}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (PubMed:10570044, PubMed:31636190). Activation by extracellular ATP induces a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis (By similarity). In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling (PubMed:23345450). Mediates synaptic transmission between neurons and from neurons to smooth muscle (By similarity). {ECO:0000250|UniProtKB:Q8K3P1, ECO:0000269|PubMed:10570044, ECO:0000269|PubMed:23345450, ECO:0000269|PubMed:31636190}.
uniprot
proteins
mass_dalton
51754
uniprot
proteins
mutagenesis
MUTAGEN 273; /note="D->Y: Abolishes localization on the cell membrane."; /evidence="ECO:0000269|PubMed:31636190
uniprot
proteins
protein_family
P2X receptor family
uniprot
proteins
pubmed
10570044
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
23345450
uniprot
proteins
pubmed
24211385
uniprot
proteins
pubmed
31636190
uniprot
proteins
sequence_length
471
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23345450, ECO:0000269|PubMed:31636190}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P56373}. Note=Localizes to the apical membranes of hair cells in the organ of Corti. {ECO:0000269|PubMed:23345450}.
uniprot
proteins
transmembrane_region
TRANSMEM 43..63; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P56373"; TRANSMEM 338..358; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P56373
uniprot
proteins