BASH
entrez
29760
canonical
uniprot
Q8WV28
canonical
ensembl
ENSG00000095585
resolver
ensp
ENSP00000224337
resolver
ensp
ENSP00000360218
resolver
ensp
ENSP00000391924
resolver
ensp
ENSP00000397487
resolver
ensp
ENSP00000512506
resolver
enst
ENST00000427367
resolver
enst
ENST00000696253
resolver
genesymbol
BASH
resolver
genesymbol
BLNK
resolver
genesymbol_syn
BASH
resolver
genesymbol_syn
BLNK
resolver
genesymbol_syn
SLP65
resolver
hgnc
HGNC:14211
resolver
uniprot
A0A8Q3WL38
resolver
uniprot
A0ACM8Q980
resolver
uniprot
F5GXS1
resolver
uniprot
O75498
resolver
uniprot
O75499
resolver
uniprot
Q2MD49
resolver
uniprot
Q2MD54
resolver
uniprot
Q2MD59
resolver
uniprot_entry
A0A8Q3WL38_HUMAN
resolver
uniprot_entry
A0ACM8Q980_HUMAN
resolver
uniprot_entry
BLNK_HUMAN
resolver
uniprot_entry
Q2MD54_HUMAN
resolver
uniprot_entry
Q2MD59_HUMAN
resolver
uniprot_sec
F5GXS1
resolver
uniprot_sec
O75498
resolver
uniprot_sec
O75499
resolver
uniprot_sec
Q2MD49
resolver
amino_acid_sequence
MDKLNKITVPASQKLRQLQKMVHDIKNNEGGIMNKIKKLKVKAPPSVPRRDYASESPADEEEQWSDDFDSDYENPDEHSDSEMYVMPAEENADDSYEPPPVEQETRPVHPALPFARGEYIDNRSSQRHSPPFSKTLPSKPSWPSEKARLTSTLPALTALQKPQVPPKPKGLLEDEADYVVPVEDNDENYIHPTESSSPPPEKAPMVNRSTKPNSSTPASPPGTASGRNSGAWETKSPPPAAPSPLPRAGKKPTTPLKTTPVASQQNASSVCEEKPIPAERHRGSSHRQEAVQSPVFPPAQKQIHQKPIPLPRFTEGGNPTVDGPLPSFSSNSTISEQEAGVLCKPWYAGACDRKSAEEALHRSNKDGSFLIRKSSGHDSKQPYTLVVFFNKRVYNIPVRFIEATKQYALGRKKNGEEYFGSVAEIIRNHQHSPLVLIDSQNNTKDSTRLKYAVKVS
uniprot
proteins
disease_involvement
DISEASE: Agammaglobulinemia 4, autosomal recessive (AGM4) [MIM:613502]: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. {ECO:0000269|PubMed:10583958}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis. {ECO:0000269|PubMed:10583958, ECO:0000269|PubMed:15270728, ECO:0000269|PubMed:16912232, ECO:0000269|PubMed:9697839}.
uniprot
proteins
mass_dalton
50466
uniprot
proteins
mutagenesis
MUTAGEN 72; /note="Y->F: Significant phosphorylation reduction; when associated with F-84; F-96 and F-178."; /evidence="ECO:0000269|PubMed:12456653, ECO:0000269|PubMed:9697839"; MUTAGEN 84; /note="Y->F: Significant phosphorylation reduction; when associated with F-72; F-96 and F-178."; /evidence="ECO:0000269|PubMed:12456653, ECO:0000269|PubMed:9697839"; MUTAGEN 96; /note="Y->F: Significant phosphorylation reduction; when associated with F-72; F-84 and F-178."; /evidence="ECO:0000269|PubMed:12456653, ECO:0000269|PubMed:9697839"; MUTAGEN 178; /note="Y->F: Significant phosphorylation reduction; when associated with F-72; F-84 and F-96."; /evidence="ECO:0000269|PubMed:9697839
uniprot
proteins
post_translational_modification
PTM: Following BCR activation, phosphorylated on tyrosine residues by SYK and LYN. When phosphorylated, serves as a scaffold to assemble downstream targets of antigen activation, including PLCG1, VAV1, GRB2 and NCK1. Phosphorylation of Tyr-84, Tyr-178 and Tyr-189 facilitates PLCG1 binding. Phosphorylation of Tyr-96 facilitates BTK binding. Phosphorylation of Tyr-72 facilitates VAV1 and NCK1 binding. Phosphorylation is required for both Ca(2+) and MAPK signaling pathways. {ECO:0000269|PubMed:12456653, ECO:0000269|PubMed:9697839}.
uniprot
proteins
pubmed
10583958
uniprot
proteins
pubmed
12456653
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15270728
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16636677
uniprot
proteins
pubmed
16912232
uniprot
proteins
pubmed
18369315
uniprot
proteins
pubmed
21930792
uniprot
proteins
pubmed
9341187
uniprot
proteins
pubmed
9697839
uniprot
proteins
sequence_length
456
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9697839}. Cell membrane {ECO:0000269|PubMed:9697839}. Note=BCR activation results in the translocation to membrane fraction.
uniprot
proteins