Gna15
entrez
14676
canonical
uniprot
P30678
canonical
ensembl
ENSMUSG00000034792
resolver
ensp
ENSMUSP00000049175
resolver
ensp
ENSMUSP00000209014
resolver
ensp
ENSMUSP00000209016
resolver
enst
ENSMUST00000043709
resolver
genesymbol
Gna15
resolver
genesymbol_syn
Gna-15
resolver
uniprot
Q8K1S0
resolver
uniprot_entry
GNA15_MOUSE
resolver
uniprot_sec
Q8K1S0
resolver
amino_acid_sequence
MARSLTWGCCPWCLTEEEKTAARIDQEINRILLEQKKQEREELKLLLLGPGESGKSTFIKQMRIIHGVGYSEEDRRAFRLLIYQNIFVSMQAMIDAMDRLQIPFSRPDSKQHASLVMTQDPYKVSTFEKPYAVAMQYLWRDAGIRACYERRREFHLLDSAVYYLSHLERISEDSYIPTAQDVLRSRMPTTGINEYCFSVKKTKLRIVDVGGQRSERRKWIHCFENVIALIYLASLSEYDQCLEENDQENRMEESLALFSTILELPWFKSTSVILFLNKTDILEDKIHTSHLATYFPSFQGPRRDAEAAKSFILDMYARVYASCAEPQDGGRKGSRARRFFAHFTCATDTQSVRSVFKDVRDSVLARYLDEINLL
uniprot
proteins
function
FUNCTION: Member of the G protein alpha subunit family that plays a crucial role in intracellular signaling. Functions as a molecular switch, transducing signals from G protein-coupled receptors (GPCRs) to downstream effectors. In collaboration with the adapter protein TTC1, promotes HRAS activation and ERK1/2 phosphorylation independently of phospholipase Cbeta signaling. Also initiates EMR2-mediated signaling, leading to activation of Akt, MAPK, and NF-kappa-B, which in turn drives macrophage differentiation and inflammatory responses. {ECO:0000250|UniProtKB:P30679}.
uniprot
proteins
mass_dalton
43536
uniprot
proteins
protein_family
G(q) subfamily
uniprot
proteins
protein_family
G-alpha family
uniprot
proteins
pubmed
12401211
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1946421
uniprot
proteins
pubmed
8838318
uniprot
proteins
sequence_length
374
uniprot
proteins