Gnal
entrez
24611
canonical
uniprot
P38406
canonical
ensembl
ENSRNOG00000010440
resolver
ensp
ENSRNOP00000025172
resolver
enst
ENSRNOT00000025172
resolver
genesymbol
Gnal
resolver
uniprot
G3V8E8
resolver
uniprot
Q64711
resolver
uniprot_entry
G3V8E8_RAT
resolver
uniprot_entry
GNAL_RAT
resolver
uniprot_sec
Q64711
resolver
amino_acid_sequence
MGCLGNSSKTAEDQGVDEKERREANKKIEKQLQKERLAYKATHRLLLLGAGESGKSTIVKQMRILHVNGSNPEEKKQKILDIRKNVKDAIVTIVSAMSTIIPPVPLANPENQFRSDYIKSIAPITDFEYSQEFFDHVKKLWDDEGVKACFERSNEYQLIDCAQYFLERIDSVSLVDYTPTDQDLLRCRVLTSGIFETRFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIYVAACSSYNMVIREDNNTNRLRESLDLFESIWNNRWLRTISIILFLNKQDMLAEKVLAGKSKIEDYFPEYANYTVPEDATPDAGEDPKVTRAKFFIRDLFLRISTATGDGKHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLKQYELL
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Guanine nucleotide-binding protein (G protein) involved as transducer in olfactory signal transduction controlled by G protein-coupled receptors (GPCRs) (PubMed:2255909, PubMed:2499043). Contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (By similarity). Signaling by an activated GPCR promotes GDP release and GTP binding (By similarity). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (By similarity). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). GNAL/G(olf) alpha specifically mediates olfactory signal transduction within the olfactory neuroepithelium and the basal ganglia following GPCRs activation (PubMed:2255909, PubMed:2499043). Acts by promoting the specific activation of adenylyl cyclase ADCY3, resulting in increased levels of the signaling molecule cAMP (PubMed:2255909). {ECO:0000250|UniProtKB:Q8CGK7, ECO:0000269|PubMed:2255909, ECO:0000269|PubMed:2499043}.
uniprot
proteins
mass_dalton
44248
uniprot
proteins
protein_family
G(s) subfamily
uniprot
proteins
protein_family
G-alpha family
uniprot
proteins
pubmed
2255909
uniprot
proteins
pubmed
2499043
uniprot
proteins
pubmed
7494450
uniprot
proteins
sequence_length
381
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8CGK7}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8CGK7}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8CGK7}. Note=Associated to the plasma membrane via lipid-anchor. {ECO:0000250|UniProtKB:P04896}.
uniprot
proteins