Coq6
entrez
299195
canonical
uniprot
Q68FU7
canonical
ensembl
ENSRNOG00000011164
resolver
ensembl
ENSRNOG00055025973
resolver
ensembl
ENSRNOG00060024764
resolver
ensembl
ENSRNOG00065027538
resolver
ensp
ENSRNOP00000014914
resolver
ensp
ENSRNOP00000094755
resolver
ensp
ENSRNOP00055036730
resolver
ensp
ENSRNOP00060035501
resolver
ensp
ENSRNOP00065038970
resolver
enst
ENSRNOT00000014913
resolver
enst
ENSRNOT00000107126
resolver
enst
ENSRNOT00055044829
resolver
enst
ENSRNOT00060042866
resolver
enst
ENSRNOT00065047493
resolver
genesymbol
Coq6
resolver
uniprot
A0A8I6AN07
resolver
uniprot_entry
A0A8I6AN07_RAT
resolver
uniprot_entry
COQ6_RAT
resolver
amino_acid_sequence
MAARIGPMAGLLCVRWWSTAQLAARGGPLVACRRWTSSSTDSVYDVVVSGGGMVGSAMACALGHDIHFHDKKILLLEAGPKKTLEKLSETYSNRVSSISLGSTTLLSSFGAWDHICNMRCKAFRRMQVWDSCSEALIMFDKDNLDDMGYIVENDVIMHAITKQLEAVADRVKVLYESKAVGYAWPGPFSLADSSPWVHITLGDGSTLQTKLLIGADGHNSGVRQAAGIQNVGWNYDQSAVVATLHLSEATENNVAWQRFLPSGPIALLPLSDTLSSLVWSTSHAHAAELVSMHEEEFVDAINSAFWSDVHHTDFVDSASAMVHHAVALLKPTKVSARQLPPSVAKVDAKSRALFPLGLGHAAEYVRPRVALIGDAAHRVHPLAGQGVNMGFGDISSLIHYLSTAAFNGKDLGSMSHLTGYETDRQRHNTALLAATDLLKRLYSTSTTPLVLLRTWGLQATNAVSPLKEQIMAFASR
uniprot
proteins
ec_number
1.14.15.45
uniprot
proteins
ec_number
1.14.15.46
uniprot
proteins
function
FUNCTION: FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-decaprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-decaprenyl)benzoic acid. Also acts downstream of COQ4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-decaprenyl)phenol to 2-methoxy-6-(all-trans-decaprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to COQ6 from NADPH via a ferredoxin/ferredoxin reductase system composed of FDX2 and FDXR. {ECO:0000255|HAMAP-Rule:MF_03193}.
uniprot
proteins
mass_dalton
51496
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03193}.
uniprot
proteins
protein_family
UbiH/COQ6 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21540551
uniprot
proteins
sequence_length
476
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03193}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03193}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03193}. Golgi apparatus {ECO:0000255|HAMAP-Rule:MF_03193, ECO:0000269|PubMed:21540551}. Cell projection {ECO:0000255|HAMAP-Rule:MF_03193, ECO:0000269|PubMed:21540551}. Note=Localizes to cell processes and Golgi apparatus in podocytes. {ECO:0000255|HAMAP-Rule:MF_03193, ECO:0000269|PubMed:21540551}.
uniprot
proteins