Slco1b2
entrez
28253
canonical
uniprot
Q9JJL3
canonical
ensembl
ENSMUSG00000030236
resolver
ensp
ENSMUSP00000044326
resolver
ensp
ENSMUSP00000282886
resolver
ensp
ENSMUSP00000282887
resolver
ensp
ENSMUSP00000282888
resolver
genesymbol
Slco1b2
resolver
genesymbol_syn
Oatp1b2
resolver
genesymbol_syn
Slc21a10
resolver
uniprot
Q9JI79
resolver
uniprot
Q9JJJ1
resolver
uniprot_entry
SO1B2_MOUSE
resolver
uniprot_sec
Q9JI79
resolver
uniprot_sec
Q9JJJ1
resolver
amino_acid_sequence
MDQTQHPSKAAQPLRSEKTRHCDGFRIFLAALSFSYICKALGGVIMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGTGCFIMGIGSILTALPHFFMGYYRYATENDISSLHNSTLTCLVNQTTSLTGTSPEIMEKGCEKGSNSYTWIYVLMGNMLRGIGETPIVPLGVSYIDDFAKEGNSSMYLGTLHTIAMIGPILGFIMSSVFAKLYVDVGYVDLRSVRITPQDARWVGAWWLGFIVNGLLCIICSIPFFFLPKIPKRSQKERKNSASLHVLKTDEDKNPVTNPTTQEKQAPANLTGFLWSLRSILTNEQYVIFLILTLLQISSFIGSFTYLFKFIEQQFGQTASQANFLLGVITIPTMASGMFLGGYLIKRLKLTLLGITKFVFFTTTMAYVFYLSYFLLICENKAFAGLTLTYDGMNPVDSHIDVPLSYCNSDCICDKNQWEPVCGENGVTYISPCLAGCKSFRGDKKLMNIEFYDCSCVSGSGFQKGNHSARLGECPRDKCKTKYYFYITFQVIISFFTALGSTSLMLILIRSVQPELKSLGMGFHSLVVRTLGGILAPVYYGALIDRTCMKWSVTSCGARGACRLYNSRLFGMIYVGLSIALKTPILLLYVALIYVMKRKMKRNDNKILENGRKFTDEGNPEPVNNNGYSCVPSDEKNSETPL
uniprot
proteins
function
FUNCTION: Mediates the Na(+)-independent uptake of organic anions such as taurochlate, bromosulfophthalein and steroid conjugates (estrone 3-sulfate, 17-beta-glucuronosyl estradiol, dehydroepiandrosterone sulfate). Also transports prostaglandin E2 and L-thyroxine (T4). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment. Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions. {ECO:0000250|UniProtKB:Q9QZX8}.
uniprot
proteins
mass_dalton
76729
uniprot
proteins
protein_family
Organo anion transporter (TC 2.A.60) family
uniprot
proteins
pubmed
10833452
uniprot
proteins
pubmed
17208939
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
689
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 27..46; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 66..86; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 93..117; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 164..192; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 212..232; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 251..275; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 327..348; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 369..392; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 397..420; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 534..556; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 566..591; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 626..643; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins