Nop10
entrez
66181
canonical
uniprot
Q9CQS2
canonical
ensembl
ENSMUSG00000027133
resolver
ensp
ENSMUSP00000028553
resolver
enst
ENSMUST00000028553
resolver
genesymbol
Nop10
resolver
genesymbol_syn
Nola3
resolver
uniprot_entry
NOP10_MOUSE
resolver
amino_acid_sequence
MFLQYYLNEQGDRVYTLKKFDPMGQQTCSAHPARFSPDDKYSRHRITIKKRFKVLMTQQPRPVL
uniprot
proteins
function
FUNCTION: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
7706
uniprot
proteins
protein_family
NOP10 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
64
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}. Nucleus, Cajal body {ECO:0000250}. Note=Also localized to Cajal bodies (coiled bodies). {ECO:0000250}.
uniprot
proteins