GRK1
entrez
6011
canonical
uniprot
Q15835
canonical
ensembl
ENSG00000185974
resolver
ensembl
ENSG00000288263
resolver
ensp
ENSP00000334876
resolver
ensp
ENSP00000499886
resolver
enst
ENST00000335678
resolver
enst
ENST00000672946
resolver
genesymbol
GRK1
resolver
genesymbol_syn
RHOK
resolver
hgnc
HGNC:10013
resolver
uniprot
Q53X14
resolver
uniprot_entry
GRK1_HUMAN
resolver
uniprot_sec
Q53X14
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by RCVRN, which prevents the interaction between GRK1 and RHO (By similarity). Inhibition is calcium-dependent (By similarity). Inhibited by phosphorylation of Ser-21. {ECO:0000250|UniProtKB:P28327, ECO:0000269|PubMed:15946941}.
uniprot
proteins
amino_acid_sequence
MDFGSLETVVANSAFIAARGSFDGSSSQPSRDKKYLAKLKLPPLSKCESLRDSLSLEFESVCLEQPIGKKLFQQFLQSAEKHLPALELWKDIEDYDTADNDLQPQKAQTILAQYLDPQAKLFCSFLDEGIVAKFKEGPVEIQDGLFQPLLQATLAHLGQAPFQEYLGSLYFLRFLQWKWLEAQPMGEDWFLDFRVLGKGGFGEVSACQMKATGKLYACKKLNKKRLKKRKGYQGAMVEKKILMKVHSRFIVSLAYAFETKADLCLVMTIMNGGDIRYHIYNVNEENPGFPEPRALFYTAQIICGLEHLHQRRIVYRDLKPENVLLDNDGNVRISDLGLAVELLDGQSKTKGYAGTPGFMAPELLQGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKHRIISEPVKYPDKFSQASKDFCEALLEKDPEKRLGFRDETCDKLRAHPLFKDLNWRQLEAGMLMPPFIPDSKTVYAKDIQDVGAFSTVKGVAFDKTDTEFFQEFATGNCPIPWQEEMIETGIFGELNVWRSDGQMPDDMKGISGGSSSSSKSGMCLVS
uniprot
proteins
disease_involvement
DISEASE: Night blindness, congenital stationary, Oguchi type 2 (CSNBO2) [MIM:613411]: A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia. Congenital stationary night blindness Oguchi type is associated with fundus discoloration and abnormally slow dark adaptation. {ECO:0000269|PubMed:17070587, ECO:0000269|PubMed:19753316, ECO:0000269|PubMed:22959359, ECO:0000269|PubMed:27511724, ECO:0000269|PubMed:28418496, ECO:0000269|PubMed:28511019, ECO:0000269|PubMed:33252155, ECO:0000269|PubMed:36417138, ECO:0000269|PubMed:9020843}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.11.14
uniprot
proteins
function
FUNCTION: Retina-specific kinase involved in the regulation of phototransduction, playing a key role in terminating the light-activated rhodopsin (RHO) signal in rod photoreceptors. Following light activation, it phosphorylates RHO, thereby promoting binding of S-arrestin (SAG) which then blocks transducin-mediated opsin signaling (PubMed:15946941). This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity). May play a role in the maintenance of the outer nuclear layer in the retina (By similarity). {ECO:0000250|UniProtKB:P28327, ECO:0000250|UniProtKB:Q9WVL4, ECO:0000269|PubMed:15946941}.
uniprot
proteins
mass_dalton
63526
uniprot
proteins
mutagenesis
MUTAGEN 21; /note="S->E: Not phosphorylated by PKA."; /evidence="ECO:0000269|PubMed:15946941"; MUTAGEN 219; /note="K->A: Loss of autophosphorylation and RHO phosphorylation."; /evidence="ECO:0000269|PubMed:15946941
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated, Ser-21 is a minor site of autophosphorylation compared to Ser-491 and Thr-492 (By similarity). Phosphorylation at Ser-21 is regulated by light and activated by cAMP. {ECO:0000250, ECO:0000269|PubMed:15946941}.; PTM: Farnesylation is required for full activity. {ECO:0000250|UniProtKB:P28327}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
GPRK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11717351
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15946941
uniprot
proteins
pubmed
17070587
uniprot
proteins
pubmed
19753316
uniprot
proteins
pubmed
22959359
uniprot
proteins
pubmed
25979333
uniprot
proteins
pubmed
27511724
uniprot
proteins
pubmed
28418496
uniprot
proteins
pubmed
28511019
uniprot
proteins
pubmed
33252155
uniprot
proteins
pubmed
36417138
uniprot
proteins
pubmed
8812493
uniprot
proteins
pubmed
9020843
uniprot
proteins
pubmed
9147475
uniprot
proteins
pubmed
9268593
uniprot
proteins
sequence_length
563
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P28327}; Lipid-anchor {ECO:0000250|UniProtKB:P28327}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q9WVL4}. Note=Subcellular location is not affected by light or dark conditions. {ECO:0000250|UniProtKB:Q9WVL4}.
uniprot
proteins