Nell2
entrez
54003
canonical
uniprot
Q61220
canonical
ensembl
ENSMUSG00000022454
resolver
ensp
ENSMUSP00000074751
resolver
ensp
ENSMUSP00000131665
resolver
ensp
ENSMUSP00000228959
resolver
ensp
ENSMUSP00000228960
resolver
ensp
ENSMUSP00000229026
resolver
ensp
ENSMUSP00000229028
resolver
enst
ENSMUST00000075275
resolver
enst
ENSMUST00000166170
resolver
genesymbol
Nell2
resolver
genesymbol_syn
Mel91
resolver
uniprot
Q80UM5
resolver
uniprot_entry
NELL2_MOUSE
resolver
uniprot_sec
Q80UM5
resolver
amino_acid_sequence
MHAMESRVLLRTFCVILGLGAVWGLGVDPSLQIDVLTELELGESTDGVRQVPGLHNGTKAFLFQESPRSIKASTATAERFFQKLRNKHEFTILVTLKQIHLNSGVILSIHHLDHRYLELESSGHRNEIRLHYRSGTHRPHTEVFPYILADAKWHKLSLAFSASHLILHIDCNKIYERVVEMPSTDLPLGTTFWLGQRNNAHGYFKGIMQDVHVLVMPQGFIAQCPDLNRTCPTCNDFHGLVQKIMELQDILSKTSAKLSRAEQRMNRLDQCYCERTCTVKGTTYRESESWTDGCKNCTCLNGTIQCETLVCPAPDCPPKSAPAYVDGKCCKECKSTCQFQGRSYFEGERNTVYSSSGMCVLYECKDQTMKLVENIGCPPLDCPESHQIALSHSCCKVCKGYDFCSEKHTCMENSVCRNLNDRAVCSCRDGFRALREDNAYCEDIDECAEGRHYCRENTMCVNTPGSFMCICKTGYIRIDDYSCTEHDECLTNQHNCDENALCFNTVGGHNCVCKPGYTGNGTTCKAFCKDGCRNGGACIAANVCACPQGFTGPSCETDIDECSEGFVQCDSRANCINLPGWYHCECRDGYHDNGMFAPGGESCEDIDECGTGRHSCTNDTICFNLDGGYDCRCPHGKNCTGDCVHEGKVKHTGQIWVLENDRCSVCSCQTGFVMCRRMVCDCENPTVDLSCCPECDPRLSSQCLHQNGETVYNSGDTWVQDCRQCRCLQGEVDCWPLACPEVECEFSVLPENECCPRCVTDPCQADTIRNDITKTCLDEMNVVRFTGSSWIKHGTECTLCQCKNGHLCCSVDPQCLQEL
uniprot
proteins
function
FUNCTION: Plays multiple roles in neural tissues, regulates neuronal proliferation, survival, differentiation, polarization, as well as axon guidance and synaptic functions. Plays an important role in axon development during neuronal differentiation through the MAPK intracellular signaling pathway (By similarity) (PubMed:26586761, PubMed:32198364). Via binding to its receptor ROBO3, plays a role in axon guidance, functioning as a repulsive axon guidance cue that contributes to commissural axon guidance to the midline (PubMed:26586761, PubMed:32198364). Required for neuron survival through the modulation of MAPK signaling pathways too. Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity). {ECO:0000250|UniProtKB:Q62918, ECO:0000269|PubMed:26586761, ECO:0000269|PubMed:32198364}.; FUNCTION: Epididymal-secreted protein that signals through a ROS1-pathway to regulate the epididymal initial segment (IS) maturation, sperm maturation and male fertility. {ECO:0000269|PubMed:32499443, ECO:0000269|PubMed:37095084}.
uniprot
proteins
mass_dalton
91432
uniprot
proteins
mutagenesis
MUTAGEN 451; /note="R->A: Strong (120-fold) reduction of affinity towards ROBO3; when associated with A-453. Reduced axon repulsive activity; when associated with A-453."; /evidence="ECO:0000269|PubMed:32198364"; MUTAGEN 453; /note="Y->A: Strong (120-fold) reduction of affinity towards ROBO3; when associated with A-451. Reduced axon repulsive activity; when associated with A-453."; /evidence="ECO:0000269|PubMed:32198364"; MUTAGEN 455; /note="R->A: Mildly (2.4-fold) reduction of affinity towards ROBO3. Does not affect axon repulsive activity."; /evidence="ECO:0000269|PubMed:32198364"; MUTAGEN 480; /note="D->A: Strong (120-fold) reduction of affinity towards ROBO3; when associated with A-481."; /evidence="ECO:0000269|PubMed:32198364"; MUTAGEN 481; /note="Y->A: Strong (120-fold) reduction of affinity towards ROBO3; when associated with A-480."; /evidence="ECO:0000269|PubMed:32198364"; MUTAGEN 501; /note="L->A: Abolishes binding to ROBO3; when associated with A-503. Abolishes axon repulsive activity; when associated with A-503."; /evidence="ECO:0000269|PubMed:32198364"; MUTAGEN 503; /note="F->A: Abolishes binding to ROBO3; when associated with A-503. Abolishes axon repulsive activity; when associated with A-503."; /evidence="ECO:0000269|PubMed:32198364"; MUTAGEN 512; /note="V->A: Mildly (2.4-fold) reduced affinity for ROBO3. Does not affect axon repulsive activity."; /evidence="ECO:0000269|PubMed:32198364
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26586761
uniprot
proteins
pubmed
32198364
uniprot
proteins
pubmed
32499443
uniprot
proteins
pubmed
37095084
uniprot
proteins
sequence_length
819
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:32499443}. Note=Detected in the epididymal lumen. {ECO:0000269|PubMed:32499443}.
uniprot
proteins