Slfn14
entrez
237890
canonical
uniprot
V9GXG1
canonical
ensembl
ENSMUSG00000082101
resolver
ensp
ENSMUSP00000139132
resolver
enst
ENSMUST00000163961
resolver
genesymbol
Slfn14
resolver
uniprot_entry
SLN14_MOUSE
resolver
amino_acid_sequence
MPYAEITVNLGKVTLGEENRKKMTNSCLKRHENSSLVQAVCALLNSGGGVIKAEINDKSYSYRCHGLGQDLETSFQKLLPSGSQKHLDYMQQNHDLLIFVKSWSPDASSLPLRICSLRSNLYQRDVTSAINLCANGALELLREKESRAQRGTPRLHSQDHILNRTIQEEEDIKMCALEFLKKDKLNFKEKLSFTESTHVEFKRFTTKKIVPRIKETLAHYVSAFANTQGGYIIIGVDDKSKEVFGCKKEKVNPDSLKTEIKNCIEKLPTYHFCREKPKVNFTTKILKVYQKEALYGFVCVVQVEPFCCVVFAEDPDSWIMENNIVTRLKVQQWVEMMLDIQSDPSSGFPTINDSAHLMTPALSAPRRPAYLTKVLEHKETLQRHFFSVTQENLQFQPESLCKKLFSDHEGLEDLLKAQTHPCSHGIVIFSRSWAGDIGLMREEKVLCDALLVAVGSPLVLYTILTDPSSTGRADYTQNTALQLKRQLQTLGGYPGKICVIPRVIYLASRGSRPDQPPVYYPRPYTLSSKAEVEDLLQGLVLVSLCSRSVLSDQLGCEFFKQCLEEQANTLSRNLQESRELFIHCLPGTRKTALAIKMVEKIKDVFHCKPKEILFVCENDSLRDFVMQQVTCRAVTRRTFMREEFPKIKHIVMDETENFCSRHGDWYVKAKSTTHPKANGAANEHPHHGILWLFLDPFQVRHADGSGLPVPSAQFPRKMITSEIHCAVEIAKVMKDEMKRMQENPPSMGLPDTLATFQEAPYEEAMRAGALPGVCEIKANLTPEQIANYVAEKCHSLFHEGYLPQDIAILYRRREDRGQYKDVLLKAMARGTTEVAFNSAADVCADGIILDSVEQFSGMVRNIVFGLCPESVHSEGVHKLCFASKAIKHLYLLYGGRTAF
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: [Protein SLFN14]: Shows no ribosome-associated and endoribonuclease activities. {ECO:0000269|PubMed:25996083}.; FUNCTION: [C-terminally truncated SLFN14 endoribonuclease]: Displays polysome-associated endoribonuclease activity towards mRNAs and rRNAs (PubMed:25996083). May play a role in RNA surveillance pathways by recognizing stalled ribosomes and triggering endonucleolytic cleavage of aberrant mRNAs (Probable). Cleaves different types of rRNAs and mRNAs in a magnesium- and manganese-dependent and ATP-independent manner. Involved in correct maturation of megakaryocytes and especially important for proplatelet extension (By similarity). {ECO:0000250|UniProtKB:G1SRW8, ECO:0000250|UniProtKB:P0C7P3, ECO:0000269|PubMed:25996083, ECO:0000305|PubMed:25996083}.
uniprot
proteins
mass_dalton
101690
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19619625
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25996083
uniprot
proteins
sequence_length
899
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Protein SLFN14]: Nucleus {ECO:0000250|UniProtKB:P0C7P3}.
uniprot
proteins