Taar8c
entrez
494546
canonical
uniprot
Q5QD05
canonical
ensembl
ENSMUSG00000100004
resolver
ensp
ENSMUSP00000133193
resolver
enst
ENSMUST00000170267
resolver
genesymbol
Taar8c
resolver
uniprot
B2RT38
resolver
uniprot_entry
TAA8C_MOUSE
resolver
uniprot_sec
B2RT38
resolver
amino_acid_sequence
MTSNFSQPALQLCYENTNGSCIKTPYSPGPRVILYMVYGFGAVLAVCGNLLVVISVLHFKQLHSPANFLIASLASADFLVGISVMPFSMVRSIESCWYFGDAFCSLHSCCDVAFCYSSALHLCFISVDRYIAVTDPLVYPTKFTVSVSGICISISWILPLVYSSAVFYTGISAKGIESLVSALNCVGGCQVVVNQDWVLISFLLFFIPTVVMIILYSKIFLVAKQQAVKIETSVSGNRGESSSESHKARVAKRERKAAKTLGVTVVAFMVSWLPYTIDALVDAFMGFITPAYVYEICCWSAYYNSAMNPLIYAFFYPWFRKAIKLILSGKILKGHSSTTNLFSE
uniprot
proteins
function
FUNCTION: Olfactory receptor specific for trace amines, such ascyclohexylamine (1-MPD) (PubMed:37225986). Trace amine compounds are enriched in animal body fluids and act on trace amine-associated receptors (TAARs) to elicit both intraspecific and interspecific innate behaviors (PubMed:37225986). Ligand-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL or GNAS) (Probable). {ECO:0000269|PubMed:37225986, ECO:0000305}.
uniprot
proteins
mass_dalton
37890
uniprot
proteins
mutagenesis
MUTAGEN 13; /note="C->S: Does not affect trace-amine receptor activity."; /evidence="ECO:0000269|PubMed:37225986"; MUTAGEN 21; /note="C->S: Decreased trace-amine receptor activity."; /evidence="ECO:0000269|PubMed:37225986"; MUTAGEN 96; /note="C->S: Does not affect trace-amine receptor activity."; /evidence="ECO:0000269|PubMed:37225986"; MUTAGEN 108..112; /note="SCCDV->TCCDT: Promotes trace-amine receptor activity toward polyamines, such as spermidine."; /evidence="ECO:0000269|PubMed:37225986"; MUTAGEN 111; /note="D->A: Abolished trace-amine receptor activity."; /evidence="ECO:0000269|PubMed:37225986"; MUTAGEN 115; /note="C->A: Does not affect trace-amine receptor activity."; /evidence="ECO:0000269|PubMed:37225986"; MUTAGEN 185; /note="C->S: Decreased trace-amine receptor activity."; /evidence="ECO:0000269|PubMed:37225986"; MUTAGEN 272; /note="W->A: Abolished trace-amine receptor activity."; /evidence="ECO:0000269|PubMed:37225986"; MUTAGEN 302; /note="Y->A: Abolished trace-amine receptor activity."; /evidence="ECO:0000269|PubMed:37225986
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15718104
uniprot
proteins
pubmed
16878137
uniprot
proteins
pubmed
23624375
uniprot
proteins
pubmed
37225986
uniprot
proteins
sequence_length
344
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5QD06}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..52; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 68..88; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 112..132; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 147..167; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 196..216; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 261..281; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 283..303; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins