Mfn1
entrez
192647
canonical
uniprot
Q8R4Z9
canonical
ensembl
ENSRNOG00000011057
resolver
ensp
ENSRNOP00000060265
resolver
ensp
ENSRNOP00000073448
resolver
ensp
ENSRNOP00000087917
resolver
enst
ENSRNOT00000065144
resolver
enst
ENSRNOT00000077170
resolver
enst
ENSRNOT00000116019
resolver
genesymbol
Mfn1
resolver
genesymbol_syn
Fzo1b
resolver
uniprot
A0A0G2K5J3
resolver
uniprot
A0A8I6GGI5
resolver
uniprot
D3ZR27
resolver
uniprot_entry
A0A0G2K5J3_RAT
resolver
uniprot_entry
A0A8I6GGI5_RAT
resolver
uniprot_entry
D3ZR27_RAT
resolver
uniprot_entry
MFN1_RAT
resolver
amino_acid_sequence
MAETVSPLKHFVLAKKAITAIFGQLLEFVTEGSHFVEATYRNPELDRIATEDDLVEIQGYRNKLAVIGEVLSRRHMKVAFFGRTSSGKSSVINAMLWDKVLPSGIGHTTNCFLSVEGTDGDKAYLMTEGSDEKKSVKTVNQLAHALHMDKDLKAGCLVHVFWPKAKCALLRDDLVLVDSPGTDVTTELDIWIDKFCLDADVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFILNNRWDASASEPEYMEDVRRQHMERCLHFLVEELKVVSPLEARNRIFFVSAKEVLNSRMNKAQGMPEGGGALAEGFQARLQEFQNFEQTFEECISQSAVKTKFEQHTIRAKQILDTVKNILDSVNVAAAEKRVYSMEEREDQIDRLDFIRNQMNLLTMDVKKKIKEVTEEVANKVSCAMTDEICRLSVLVDEFCSEFHPTPSVLKVYKSELNKHIEDGMGRNLADRCTSEVNASILQSQQEIIENLKPLLPAGIQNKLHTLIPCKKFDLSYDLNCHKLCSDFQEDIVFRFSLGWSSLVHRFLGSTNAQRVLLGLSEPIFQVPRSLASTPTAPSNPAAPDNAAQEELMITLITGLASLTSRTSMGIIVVGGVIWKTVGWKLISVTLSMYGALYLYERLTWTTRAKERAFKQQFVNYATEKLQMIVKFTSANCSHQVQQEMATTFARLCQQVDVTQKHLEEEIARLSKEIDQLEKIQNNSKLLRNKAVQLERELENFSKQFLHPSSGES
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12589796, PubMed:14561718). Membrane clustering requires GTPase activity. It may involve a major rearrangement of the coiled coil domains (By similarity). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events (PubMed:14561718). Overexpression induces the formation of mitochondrial networks (in vitro) (PubMed:14561718). Has low GTPase activity (By similarity). {ECO:0000250|UniProtKB:Q8IWA4, ECO:0000269|PubMed:12589796, ECO:0000269|PubMed:14561718}.
uniprot
proteins
mass_dalton
83847
uniprot
proteins
mutagenesis
MUTAGEN 88; /note="K->T: Induces partial mitochondria fragmentation; when overexpressed."; /evidence="ECO:0000269|PubMed:14561718
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by non-degradative ubiquitin by PRKN (By similarity). Deubiquitination by USP30 inhibits mitochondrial fusion (By similarity). Ubiquitinated by MARCHF5. When mitochondria are depolarized and dysfunctional, it is ubiquitinated by a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that contains FBXO7 and PRKN (By similarity). {ECO:0000250|UniProtKB:Q811U4, ECO:0000250|UniProtKB:Q8IWA4}.
uniprot
proteins
protein_family
Dynamin/Fzo/YdjA family
uniprot
proteins
protein_family
Mitofusin subfamily
uniprot
proteins
protein_family
TRAFAC class dynamin-like GTPase superfamily
uniprot
proteins
pubmed
12589796
uniprot
proteins
pubmed
14561718
uniprot
proteins
pubmed
14592431
uniprot
proteins
pubmed
17105775
uniprot
proteins
sequence_length
741
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:14561718}; Multi-pass membrane protein {ECO:0000269|PubMed:14561718}.
uniprot
proteins
transmembrane_region
TRANSMEM 585..605; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 609..629; /note="Helical; Name=2"; /evidence="ECO:0000255
uniprot
proteins