Cxcl12
entrez
20315
canonical
uniprot
P40224
canonical
ensembl
ENSMUSG00000061353
resolver
ensp
ENSMUSP00000072800
resolver
ensp
ENSMUSP00000108487
resolver
ensp
ENSMUSP00000108492
resolver
enst
ENSMUST00000073043
resolver
genesymbol
Cxcl12
resolver
genesymbol_syn
Sdf1
resolver
uniprot
H7BX38
resolver
uniprot
Q4FJL5
resolver
uniprot
Q543V6
resolver
uniprot_entry
H7BX38_MOUSE
resolver
uniprot_entry
SDF1_MOUSE
resolver
uniprot_sec
Q4FJL5
resolver
uniprot_sec
Q543V6
resolver
amino_acid_sequence
MDAKVVAVLALVLAALCISDGKPVSLSYRCPCRFFESHIARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNKRLKM
uniprot
proteins
function
FUNCTION: Chemoattractant active on T-lymphocytes and monocytes but not neutrophils (By similarity). Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis (By similarity). Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for CXCL12/SDF-1 (By similarity). Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner (By similarity). Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase (By similarity). Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins (By similarity). CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase (By similarity). Plays a protective role after myocardial infarction (By similarity). Induces down-regulation and internalization of ACKR3 expressed in various cells (By similarity). Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation (PubMed:8757135). Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells (PubMed:8134392). {ECO:0000250|UniProtKB:P48061, ECO:0000269|PubMed:8134392, ECO:0000269|PubMed:8757135}.
uniprot
proteins
mass_dalton
10561
uniprot
proteins
protein_family
Intercrine alpha (chemokine CxC) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
7982471
uniprot
proteins
pubmed
8134392
uniprot
proteins
pubmed
8342023
uniprot
proteins
pubmed
8757135
uniprot
proteins
sequence_length
93
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins