SARS
entrez
6301
canonical
uniprot
P49591
canonical
ensembl
ENSG00000031698
resolver
ensp
ENSP00000234677
resolver
ensp
ENSP00000358939
resolver
enst
ENST00000234677
resolver
enst
ENST00000369923
resolver
genesymbol
SARS
resolver
genesymbol
SARS1
resolver
genesymbol_syn
SARS
resolver
genesymbol_syn
SERS
resolver
hgnc
HGNC:10537
resolver
uniprot
B2R6Y9
resolver
uniprot
Q0VGA5
resolver
uniprot
Q5T5C7
resolver
uniprot
Q5T5C8
resolver
uniprot
Q9NSE3
resolver
uniprot_entry
Q0VGA5_HUMAN
resolver
uniprot_entry
Q5T5C7_HUMAN
resolver
uniprot_entry
SYSC_HUMAN
resolver
uniprot_sec
B2R6Y9
resolver
uniprot_sec
Q5T5C8
resolver
uniprot_sec
Q9NSE3
resolver
amino_acid_sequence
MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLCSKTIGEKMKKKEPVGDDESVPENVLSFDDLTADALANLKVSQIKKVRLLIDEAILKCDAERIKLEAERFENLREIGNLLHPSVPISNDEDVDNKVERIWGDCTVRKKYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYIPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDNSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGLSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFEEMITTAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTICAILENYQTEKGITVPEKLKEFMPPGLQELIPFVKPAPIEQEPSKKQKKQHEGSKKKAAARDVTLENRLQNMEVTDA
uniprot
proteins
disease_involvement
DISEASE: Neurodevelopmental disorder with microcephaly, ataxia, and seizures (NEDMAS) [MIM:617709]: An autosomal recessive disorder characterized by delayed psychomotor development, intellectual disability, seizures apparent in infancy, impaired speech, and aggressive behavior. Additional features include microcephaly, ataxia, and muscle weakness. {ECO:0000269|PubMed:28236339, ECO:0000269|PubMed:34570399, ECO:0000269|PubMed:35790048}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Note=A splice site deletion resulting in a five amino acid in-frame insertion in SARS1, is associated with autosomal dominant complex spastic paraplegia with ataxia, intellectual disability, developmental delay and seizures, but without microcephaly. {ECO:0000269|PubMed:36041817}.
uniprot
proteins
ec_number
6.1.1.11
uniprot
proteins
function
FUNCTION: Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) (PubMed:22353712, PubMed:24095058, PubMed:26433229, PubMed:28236339, PubMed:34570399, PubMed:36041817, PubMed:9431993). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (PubMed:26433229, PubMed:28236339, PubMed:34570399, PubMed:9431993). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC (PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA (PubMed:19423847, PubMed:19423848, PubMed:24940000). {ECO:0000269|PubMed:19423847, ECO:0000269|PubMed:19423848, ECO:0000269|PubMed:22353712, ECO:0000269|PubMed:24095058, ECO:0000269|PubMed:24940000, ECO:0000269|PubMed:26433229, ECO:0000269|PubMed:28236339, ECO:0000269|PubMed:34570399, ECO:0000269|PubMed:36041817, ECO:0000269|PubMed:9431993}.
uniprot
proteins
mass_dalton
58777
uniprot
proteins
mutagenesis
MUTAGEN 2..14; /note="Missing: Abolishes DNA binding."; /evidence="ECO:0000269|PubMed:24940000"; MUTAGEN 9; /note="R->A: Strongly decreased enzyme activity."; /evidence="ECO:0000269|PubMed:26433229"; MUTAGEN 44; /note="R->A: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:26433229"; MUTAGEN 51; /note="D->A: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:26433229"; MUTAGEN 54; /note="N->A: Strongly decreased enzyme activity."; /evidence="ECO:0000269|PubMed:26433229"; MUTAGEN 55; /note="K->A: Moderately decreased enzyme activity."; /evidence="ECO:0000269|PubMed:26433229"; MUTAGEN 58; /note="N->A: Moderately decreased enzyme activity."; /evidence="ECO:0000269|PubMed:26433229"; MUTAGEN 61; /note="S->A: Moderately decreased enzyme activity."; /evidence="ECO:0000269|PubMed:26433229"; MUTAGEN 75..97; /note="Missing: Decreased enzyme activity. Abolishes DNA binding."; /evidence="ECO:0000269|PubMed:24095058, ECO:0000269|PubMed:24940000"; MUTAGEN 104; /note="K->A: Moderately decreased enzyme activity."; /evidence="ECO:0000269|PubMed:26433229"; MUTAGEN 107; /note="R->A: Moderately decreased enzyme activity."; /evidence="ECO:0000269|PubMed:26433229"; MUTAGEN 254..261; /note="Missing: Mildly decreased enzyme activity. Nearly abolishes DNA binding."; /evidence="ECO:0000269|PubMed:24095058, ECO:0000269|PubMed:24940000"; MUTAGEN 378; /note="D->R: Retains nuclear location and abolishes enzyme activity; when associated with V-383."; /evidence="ECO:0000269|PubMed:22353712"; MUTAGEN 383; /note="F->V: Abolishes nuclear location. Decreases enzyme activity. Retains nuclear location and abolishes enzyme activity; when associated with R-378."; /evidence="ECO:0000269|PubMed:22353712"; MUTAGEN 413..420; /note="Missing: Abolishes DNA binding."; /evidence="ECO:0000269|PubMed:24940000"; MUTAGEN 429; /note="T->A: Catalytically inactive. Loss of serine binding. No effect on nuclear location."; /evidence="ECO:0000269|PubMed:22353712, ECO:0000269|PubMed:28236339"; MUTAGEN 482..514; /note="Missing: Abolishes nuclear localization."; /evidence="ECO:0000269|PubMed:22353712"; MUTAGEN 482; /note="K->A: Abolishes nuclear localization; when associated with A-485 and A-493."; /evidence="ECO:0000269|PubMed:22353712"; MUTAGEN 485; /note="K->A: Abolishes nuclear localization; when associated with A-482 and A-493."; /evidence="ECO:0000269|PubMed:22353712"; MUTAGEN 493; /note="K->A: Abolishes nuclear localization; when associated with A-482 and A-485."; /evidence="ECO:0000269|PubMed:22353712
uniprot
proteins
pathway_participation
PATHWAY: Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.
uniprot
proteins
protein_family
Class-II aminoacyl-tRNA synthetase family
uniprot
proteins
protein_family
Type-1 seryl-tRNA synthetase subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19423847
uniprot
proteins
pubmed
19423848
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22353712
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24095058
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24940000
uniprot
proteins
pubmed
26433229
uniprot
proteins
pubmed
28236339
uniprot
proteins
pubmed
28655767
uniprot
proteins
pubmed
34268557
uniprot
proteins
pubmed
34570399
uniprot
proteins
pubmed
35790048
uniprot
proteins
pubmed
36041817
uniprot
proteins
pubmed
9431993
uniprot
proteins
sequence_length
514
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22353712, ECO:0000269|PubMed:28236339, ECO:0000269|PubMed:34570399, ECO:0000269|PubMed:36041817}. Nucleus {ECO:0000269|PubMed:22353712, ECO:0000269|PubMed:34570399, ECO:0000269|PubMed:36041817}. Note=Predominantly cytoplasmic, but a minor proportion is also found in the nucleus. {ECO:0000269|PubMed:22353712, ECO:0000269|PubMed:34570399, ECO:0000269|PubMed:36041817}.
uniprot
proteins