Sry
entrez
21674
canonical
uniprot
Q05738
canonical
ensembl
ENSMUSG00000069036
resolver
ensp
ENSMUSP00000088717
resolver
genesymbol
Sry
resolver
genesymbol_syn
Tdf
resolver
genesymbol_syn
Tdy
resolver
uniprot
Q53WV7
resolver
uniprot_entry
Q53WV7_MOUSE
resolver
uniprot_entry
SRY_MOUSE
resolver
amino_acid_sequence
MEGHVKRPMNAFMVWSRGERHKLAQQNPSMQNTEISKQLGCRWKSLTEAEKRPFFQEAQRLKILHREKYPNYKYQPHRRAKVSQRSGILQPAVASTKLYNLLQWDRNPHAITYRQDWSRAAHLYSKNQQSFYWQPVDIPTGHLQQQQQQQQQQQFHNHHQQQQQFYDHHQQQQQQQQQQQQFHDHHQQKQQFHDHHQQQQQFHDHHHHHQEQQFHDHHQQQQQFHDHQQQQQQQQQQQFHDHHQQKQQFHDHHHHQQQQQFHDHQQQQQQFHDHQQQQHQFHDHPQQKQQFHDHPQQQQQFHDHHHQQQQKQQFHDHHQQKQQFHDHHQQKQQFHDHHQQQQQFHDHHQQQQQQQQQQQQQFHDQQLTYLLTADITGWKGIKHCTGPDPEPF
uniprot
proteins
function
FUNCTION: Transcriptional regulator that controls a genetic switch in male development (PubMed:33004521). It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (PubMed:33004521). Involved in different aspects of gene regulation including promoter activation or repression (PubMed:15170344, PubMed:8159753, PubMed:8190643). Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (PubMed:15170344, PubMed:8159753, PubMed:8190643). SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending (PubMed:15170344, PubMed:8159753, PubMed:8190643). Also involved in pre-mRNA splicing (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity). {ECO:0000250|UniProtKB:P36394, ECO:0000250|UniProtKB:Q05066, ECO:0000269|PubMed:15170344, ECO:0000269|PubMed:33004521, ECO:0000269|PubMed:8159753, ECO:0000269|PubMed:8190643}.; FUNCTION: [Isoform Sry-T]: Constitutes the major isoform, which is necessary and sufficient for initiating male sex determination. {ECO:0000269|PubMed:33004521}.; FUNCTION: [Isoform Sry-S]: Constitutes a minor isoform, which is unstable due to the presence of a degron at the C-terminus that promotes its degradation (PubMed:33004521). Not necessary and sufficient for initiating male sex determination (PubMed:33004521). {ECO:0000269|PubMed:33004521}.
uniprot
proteins
mass_dalton
49124
uniprot
proteins
mutagenesis
MUTAGEN 81; /note="K->R: Abolishes acetylation."; /evidence="ECO:0000269|PubMed:15297880"; MUTAGEN Q05738-2:394; /note="V->P: Eliminates the C-terminal degron and promotes stabilization of the protein."; /evidence="ECO:0000269|PubMed:33004521
uniprot
proteins
post_translational_modification
PTM: [Isoform Sry-S]: Degraded due to the presence of a degron at the C-terminus that promotes its degradation. {ECO:0000269|PubMed:33004521}.; PTM: Phosphorylated on serine residues by PKA (By similarity). Phosphorylation by PKA enhances its DNA-binding activity and stimulates transcription repression (By similarity). {ECO:0000250|UniProtKB:Q05066}.; PTM: Acetylation of Lys-81 contributes to its nuclear localization and enhances its interaction with KPNB1. {ECO:0000269|PubMed:15297880}.; PTM: Poly-ADP-ribosylated by PARP1 (PubMed:16904257). ADP-ribosylation reduces its DNA-binding activity (PubMed:16904257). {ECO:0000269|PubMed:16904257}.
uniprot
proteins
protein_family
SRY family
uniprot
proteins
pubmed
11085593
uniprot
proteins
pubmed
11535586
uniprot
proteins
pubmed
11784049
uniprot
proteins
pubmed
15170344
uniprot
proteins
pubmed
1518820
uniprot
proteins
pubmed
15297880
uniprot
proteins
pubmed
15469996
uniprot
proteins
pubmed
16166090
uniprot
proteins
pubmed
16414182
uniprot
proteins
pubmed
16488877
uniprot
proteins
pubmed
16904257
uniprot
proteins
pubmed
16996051
uniprot
proteins
pubmed
19349578
uniprot
proteins
pubmed
2374589
uniprot
proteins
pubmed
33004521
uniprot
proteins
pubmed
7600978
uniprot
proteins
pubmed
7670499
uniprot
proteins
pubmed
8012385
uniprot
proteins
pubmed
8159753
uniprot
proteins
pubmed
8190643
uniprot
proteins
pubmed
8355784
uniprot
proteins
sequence_length
392
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q05066}. Cytoplasm {ECO:0000269|PubMed:11535586, ECO:0000269|PubMed:15469996, ECO:0000269|PubMed:16488877, ECO:0000269|PubMed:19349578}. Nucleus {ECO:0000269|PubMed:19349578}. Note=Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization (By similarity). Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (PubMed:15469996). Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus (By similarity). Nuclear import is facilitated by XPO4, a protein that usually acts as a nuclear export signal receptor (PubMed:19349578). {ECO:0000250|UniProtKB:Q05066, ECO:0000269|PubMed:15469996, ECO:0000269|PubMed:19349578}.
uniprot
proteins