LYPLA2
entrez
11313
canonical
uniprot
O95372
canonical
ensembl
ENSG00000011009
resolver
ensp
ENSP00000363638
resolver
ensp
ENSP00000575366
resolver
ensp
ENSP00000575369
resolver
ensp
ENSP00000575375
resolver
ensp
ENSP00000575376
resolver
ensp
ENSP00000575377
resolver
ensp
ENSP00000575378
resolver
ensp
ENSP00000596801
resolver
ensp
ENSP00000596802
resolver
ensp
ENSP00000596803
resolver
ensp
ENSP00000596804
resolver
enst
ENST00000374514
resolver
enst
ENST00000905307
resolver
enst
ENST00000905310
resolver
enst
ENST00000905316
resolver
enst
ENST00000905317
resolver
enst
ENST00000905318
resolver
enst
ENST00000905319
resolver
enst
ENST00000926742
resolver
enst
ENST00000926743
resolver
enst
ENST00000926744
resolver
enst
ENST00000926745
resolver
genesymbol
LYPLA2
resolver
genesymbol_syn
APT2
resolver
hgnc
HGNC:6738
resolver
uniprot
A0A140VJC9
resolver
uniprot
Q7Z4Z2
resolver
uniprot_entry
A0A140VJC9_HUMAN
resolver
uniprot_entry
LYPA2_HUMAN
resolver
uniprot_sec
Q7Z4Z2
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by compound 1 or (5,5-Dioxido-4H-thieno[3,2-c]thiochromen-2-yl)(4-(4-methoxyphenyl)piperazin-1-yl)methanone. {ECO:0000269|PubMed:25301951}.
uniprot
proteins
amino_acid_sequence
MCGNTMSVPLLTDAATVSGAERETAAVIFLHGLGDTGHSWADALSTIRLPHVKYICPHAPRIPVTLNMKMVMPSWFDLMGLSPDAPEDEAGIKKAAENIKALIEHEMKNGIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALSCWLPLHRAFPQAANGSAKDLAILQCHGELDPMVPVRFGALTAEKLRSVVTPARVQFKTYPGVMHSSCPQEMAAVKEFLEKLLPPV
uniprot
proteins
ec_number
3.1.2.-
uniprot
proteins
ec_number
3.1.2.22
uniprot
proteins
function
FUNCTION: Acts as an acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GSDMD, GAP43, ZDHHC6 or HRAS (PubMed:21152083, PubMed:28826475). Deacylates GAP43 (PubMed:21152083). Mediates depalmitoylation of ZDHHC6 (PubMed:28826475). Has lysophospholipase activity (PubMed:25301951). Hydrolyzes prostaglandin glycerol esters (PG-Gs) in the following order prostaglandin D2-glycerol ester (PGD2-G) > prostaglandin E2 glycerol ester (PGE2-G) > prostaglandin F2-alpha-glycerol ester (PGF2-alpha-G) (PubMed:25301951). Hydrolyzes 1-arachidonoylglycerol but not 2-arachidonoylglycerol or arachidonoylethanolamide (PubMed:25301951). {ECO:0000269|PubMed:21152083, ECO:0000269|PubMed:25301951, ECO:0000269|PubMed:28826475}.
uniprot
proteins
mass_dalton
24737
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="C->A: Abolishes palmitoylation."; /evidence="ECO:0000269|PubMed:28826475"; MUTAGEN 122; /note="S->A: Abolishes ability to mediate depalmitoylation of ZDHHC6."; /evidence="ECO:0000269|PubMed:28826475
uniprot
proteins
protein_family
AB hydrolase 2 family
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
21152083
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25301951
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28826475
uniprot
proteins
sequence_length
231
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25301951}.
uniprot
proteins