Tnfsf13b
entrez
24099
canonical
uniprot
Q9WU72
canonical
ensembl
ENSMUSG00000031497
resolver
ensp
ENSMUSP00000033892
resolver
ensp
ENSMUSP00000146694
resolver
ensp
ENSMUSP00000146904
resolver
ensp
ENSMUSP00000233976
resolver
enst
ENSMUST00000208683
resolver
genesymbol
Tnfsf13b
resolver
genesymbol_syn
Baff
resolver
genesymbol_syn
Tnlg7a
resolver
uniprot
A0A0U5J6R6
resolver
uniprot
A0A140LIP7
resolver
uniprot
Q3KP92
resolver
uniprot
Q7TQ58
resolver
uniprot
Q8BVA3
resolver
uniprot_entry
A0A0U5J6R6_MOUSE
resolver
uniprot_entry
A0A140LIP7_MOUSE
resolver
uniprot_entry
Q3KP92_MOUSE
resolver
uniprot_entry
Q8BVA3_MOUSE
resolver
uniprot_entry
TN13B_MOUSE
resolver
uniprot_sec
Q7TQ58
resolver
amino_acid_sequence
MDESAKTLPPPCLCFCSEKGEDMKVGYDPITPQKEEGAWFGICRDGRLLAATLLLALLSSSFTAMSLYQLAALQADLMNLRMELQSYRGSATPAAAGAPELTAGVKLLTPAAPRPHNSSRGHRNRRAFQGPEETEQDVDLSAPPAPCLPGCRHSQHDDNGMNLRNIIQDCLQLIADSDTPTIRKGTYTFVPWLLSFKRGNALEEKENKIVVRQTGYFFIYSQVLYTDPIFAMGHVIQRKKVHVFGDELSLVTLFRCIQNMPKTLPNNSCYSAGIARLEEGDEIQLAIPRENAQISRNGDDTFFGALKLL
uniprot
proteins
function
FUNCTION: Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. {ECO:0000269|PubMed:12867412}.; FUNCTION: Isoform 2 seems to inhibit isoform 1 secretion and bioactivity. {ECO:0000269|PubMed:12867412}.
uniprot
proteins
mass_dalton
34192
uniprot
proteins
post_translational_modification
PTM: The soluble form derives from the membrane form by proteolytic processing.; PTM: Isoform 2 is not efficiently shed from the membrane unlike isoform 1.
uniprot
proteins
protein_family
Tumor necrosis factor family
uniprot
proteins
pubmed
10359578
uniprot
proteins
pubmed
11862414
uniprot
proteins
pubmed
12867412
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
309
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein.; SUBCELLULAR LOCATION: [Tumor necrosis factor ligand superfamily member 13b, soluble form]: Secreted.
uniprot
proteins
transmembrane_region
TRANSMEM 48..68; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins