Pbld2
entrez
67307
canonical
uniprot
Q9CXN7
canonical
ensembl
ENSMUSG00000020072
resolver
ensp
ENSMUSP00000020262
resolver
ensp
ENSMUSP00000231774
resolver
ensp
ENSMUSP00000231781
resolver
enst
ENSMUST00000020262
resolver
genesymbol
Pbld2
resolver
genesymbol_syn
Mawbp1
resolver
uniprot
Q9D2W4
resolver
uniprot_entry
PBLD2_MOUSE
resolver
uniprot_sec
Q9D2W4
resolver
amino_acid_sequence
MKLPIFIADAFTATAFRGNPAAVCLLERTLDEDAHQDIAREMNLSETAFVRKLQPTDDFTQSSRFGLRWFTPEAEFPLCGHATLASAAVLFQKRKNTNSTLTFVTMSGELKARREEDGIVLDFPVYPTFPQDFHEVEDLIKAAIGDTLVQDIRYSPDTKNLLVRLSDSYDRSFLESLKVNTEPLPAIEKTGKVRGLILTVKGEPGGQTALYDFYSRCFAPWVGVAEDPVTGSTHTLLGPYWSEELGKKEMRAFQCSRRGGELDINLRPDGRVDIKGGAVIVLEGTLTA
uniprot
proteins
function
FUNCTION: Functions as a positive regulator of the antiviral immune response by modulating innate immunity and viral replication (PubMed:39362857, PubMed:39779683). Enhances IRF3-mediated innate immune signaling and promotes apoptotic cell death, thereby suppressing viral replication. Facilitates virus-induced type I interferon (IFN-I) signaling by promoting IRF3 phosphorylation. Up-regulates the type I interferon (IFN-I) response by activating the NF-kappaB signaling pathway (PubMed:34059646). This may occur through inhibition of TRIM21-mediated degradation of phosphorylated IKKbeta, thereby sustaining NF-kappaB activation to counteract viral infection (By similarity). {ECO:0000250|UniProtKB:P30039, ECO:0000269|PubMed:34059646, ECO:0000269|PubMed:39362857, ECO:0000269|PubMed:39779683}.
uniprot
proteins
mass_dalton
31983
uniprot
proteins
protein_family
PhzF family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
34059646
uniprot
proteins
pubmed
39362857
uniprot
proteins
pubmed
39779683
uniprot
proteins
sequence_length
288
uniprot
proteins