PTPRE
entrez
5791
canonical
uniprot
P23469
canonical
ensembl
ENSG00000132334
resolver
ensp
ENSP00000254667
resolver
ensp
ENSP00000303350
resolver
ensp
ENSP00000540771
resolver
ensp
ENSP00000540772
resolver
genesymbol
PTPRE
resolver
hgnc
HGNC:9669
resolver
uniprot
A8K2Z9
resolver
uniprot
Q13345
resolver
uniprot
Q5VWH3
resolver
uniprot
Q5VWH4
resolver
uniprot
Q96KQ6
resolver
uniprot
Q96P81
resolver
uniprot_entry
A8K2Z9_HUMAN
resolver
uniprot_entry
PTPRE_HUMAN
resolver
uniprot_entry
Q96P81_HUMAN
resolver
uniprot_sec
Q13345
resolver
uniprot_sec
Q5VWH3
resolver
uniprot_sec
Q5VWH4
resolver
uniprot_sec
Q96KQ6
resolver
amino_acid_sequence
MEPLCPLLLVGFSLPLARALRGNETTADSNETTTTSGPPDPGASQPLLAWLLLPLLLLLLVLLLAAYFFRFRKQRKAVVSTSDKKMPNGILEEQEQQRVMLLSRSPSGPKKYFPIPVEHLEEEIRIRSADDCKQFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHSRVILSQLDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQKSATIVMLTNLKERKEEKCHQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIQPQLPDGCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPVHAGPIVVHCSAGVGRTGTFIVIDAMMAMMHAEQKVDVFEFVSRIRNQRPQMVQTDMQYTFIYQALLEYYLYGDTELDVSSLEKHLQTMHGTTTHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEYTDYINASFIDGYRQKDYFIATQGPLAHTVEDFWRMIWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGEITIEIKNDTLSEAISIRDFLVTLNQPQARQEEQVRVVRQFHFHGWPEIGIPAEGKGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYANFK
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Isoform 1 plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function (By similarity). {ECO:0000250}.; FUNCTION: Isoform 2 acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake (By similarity). {ECO:0000250}.; FUNCTION: Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+). {ECO:0000250}.
uniprot
proteins
mass_dalton
80642
uniprot
proteins
post_translational_modification
PTM: A catalytically active cytoplasmic form (p65) is produced by proteolytic cleavage of either isoform 1, isoform 2 or isoform 3. {ECO:0000269|PubMed:10980613}.; PTM: Isoform 1 and isoform 2 are phosphorylated on tyrosine residues by tyrosine kinase Neu. {ECO:0000269|PubMed:10980613}.; PTM: Isoform 1 is glycosylated. {ECO:0000269|PubMed:10980613}.
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
protein_family
Receptor class 4 subfamily
uniprot
proteins
pubmed
10980613
uniprot
proteins
pubmed
12121439
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19167335
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
2170109
uniprot
proteins
pubmed
8610169
uniprot
proteins
pubmed
8618876
uniprot
proteins
pubmed
9914474
uniprot
proteins
sequence_length
700
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Note=Predominantly cytoplasmic. A small fraction is also associated with nucleus and membrane. Insulin induces translocation to the membrane (By similarity). {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm.
uniprot
proteins
transmembrane_region
TRANSMEM 47..69; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins