Slc16a2
entrez
20502
canonical
uniprot
O70324
canonical
ensembl
ENSMUSG00000033965
resolver
ensp
ENSMUSP00000037629
resolver
enst
ENSMUST00000042664
resolver
genesymbol
Slc16a2
resolver
genesymbol_syn
Mct8
resolver
genesymbol_syn
Xpct
resolver
genesymbol_syn
slc16a2
resolver
uniprot
Q05BA2
resolver
uniprot
Q8K3S9
resolver
uniprot_entry
MOT8_MOUSE
resolver
uniprot_entry
Q05BA2_MOUSE
resolver
uniprot_sec
Q8K3S9
resolver
amino_acid_sequence
MALPSPASEEAEGPCQEANQEYQEPVCSPVPEPEPEPEPEPEPDPEPVPVPPPEPQPEPEPQPLPDPAPLPELGFEAEPVQEPEPTPTVETRGTARGFQPPEGGFGWIVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATTGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIKMLGDKIKLAQTFQVLSTFMFVLTLLSLTYRPLLPSSQDTPSKRGAHTLRQRFLVQFRKYFNMRVFRQRTYRIWAFGIAAAALGYFVPYVHLMKYVEDKFKEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKKIYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGDYHVAFYFAGVPPIIGAVILFFVPLMHQRMFKKEQRDSSKDKMLSHDPDPNGELLPGSPTPEEPI
uniprot
proteins
function
FUNCTION: Specific thyroid hormone transmembrane transporter, that mediates both uptake and efflux of thyroid hormones across the cell membrane independently of pH or a Na(+) gradient (PubMed:31436139). Major substrates are the iodothyronines T3 and T4 and to a lesser extent rT3 and 3,3-diiodothyronine (3,3'-T2). Acts as an important mediator of thyroid hormone transport, especially T3, through the blood-brain barrier (PubMed:19147674). Mediates the efflux of 3,5-diiodo-L-tyrosine (DIT) and 3-iodo-L-tyrosine (MIT) (By similarity). {ECO:0000250|UniProtKB:P36021, ECO:0000269|PubMed:19147674, ECO:0000269|PubMed:31436139}.
uniprot
proteins
mass_dalton
60025
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Monocarboxylate porter (TC 2.A.1.13) family
uniprot
proteins
pubmed
12045143
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18687783
uniprot
proteins
pubmed
19147674
uniprot
proteins
pubmed
19641107
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31436139
uniprot
proteins
pubmed
32143555
uniprot
proteins
pubmed
9545634
uniprot
proteins
sequence_length
545
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18687783}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P36021}. Apical cell membrane {ECO:0000269|PubMed:18687783}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P36021}.
uniprot
proteins
transmembrane_region
TRANSMEM 103..123; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P36021"; TRANSMEM 150..170; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P36021"; TRANSMEM 178..198; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P36021"; TRANSMEM 207..227; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P36021"; TRANSMEM 236..256; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P36021"; TRANSMEM 265..285; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P36021"; TRANSMEM 329..349; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P36021"; TRANSMEM 363..383; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P36021"; TRANSMEM 393..413; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:P36021"; TRANSMEM 416..436; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:P36021"; TRANSMEM 454..474; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:P36021"; TRANSMEM 484..504; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:P36021
uniprot
proteins