SDC1
entrez
6382
canonical
uniprot
P18827
canonical
ensembl
ENSG00000115884
resolver
ensp
ENSP00000254351
resolver
ensp
ENSP00000370542
resolver
enst
ENST00000254351
resolver
enst
ENST00000381150
resolver
genesymbol
SDC1
resolver
genesymbol_syn
SDC
resolver
hgnc
HGNC:10658
resolver
uniprot
D6W523
resolver
uniprot
Q53QV0
resolver
uniprot
Q546D3
resolver
uniprot
Q96HB7
resolver
uniprot_entry
SDC1_HUMAN
resolver
uniprot_sec
D6W523
resolver
uniprot_sec
Q53QV0
resolver
uniprot_sec
Q546D3
resolver
uniprot_sec
Q96HB7
resolver
amino_acid_sequence
MRRAALWLWLCALALSLQPALPQIVATNLPPEDQDGSGDDSDNFSGSGAGALQDITLSQQTPSTWKDTQLLTAIPTSPEPTGLEATAASTSTLPAGEGPKEGEAVVLPEVEPGLTAREQEATPRPRETTQLPTTHLASTTTATTAQEPATSHPHRDMQPGHHETSTPAGPSQADLHTPHTEDGGPSATERAAEDGASSQLPAAEGSGEQDFTFETSGENTAVVAVEPDRRNQSPVDQGATGASQGLLDRKEVLGGVIAGGLVGLIFAVCLVGFMLYRMKKKDEGSYSLEEPKQANGGAYQKPTKQEEFYA
uniprot
proteins
function
FUNCTION: Cell surface proteoglycan that contains both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix (By similarity). Regulates exosome biogenesis in concert with SDCBP and PDCD6IP (PubMed:22660413). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (By similarity). {ECO:0000250|UniProtKB:P18828, ECO:0000269|PubMed:22660413}.
uniprot
proteins
mass_dalton
32462
uniprot
proteins
post_translational_modification
PTM: Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3. {ECO:0000269|PubMed:9169435}.
uniprot
proteins
protein_family
Syndecan proteoglycan family
uniprot
proteins
pubmed
1339431
uniprot
proteins
pubmed
15177497
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16007225
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22660413
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2324102
uniprot
proteins
pubmed
23395182
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
32337544
uniprot
proteins
pubmed
36213313
uniprot
proteins
pubmed
9050911
uniprot
proteins
pubmed
9169435
uniprot
proteins
sequence_length
310
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}. Secreted {ECO:0000269|PubMed:9169435}. Secreted, extracellular exosome {ECO:0000269|PubMed:22660413}. Note=Shedding of the ectodomain produces a soluble form. {ECO:0000269|PubMed:9169435}.
uniprot
proteins
transmembrane_region
TRANSMEM 255..275; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins