HDC
entrez
3067
canonical
uniprot
P19113
canonical
ensembl
ENSG00000140287
resolver
ensp
ENSP00000267845
resolver
ensp
ENSP00000440252
resolver
ensp
ENSP00000530582
resolver
ensp
ENSP00000530583
resolver
genesymbol
HDC
resolver
hgnc
HGNC:4855
resolver
uniprot
A1L4G0
resolver
uniprot
B7ZM01
resolver
uniprot_entry
DCHS_HUMAN
resolver
uniprot_sec
A1L4G0
resolver
uniprot_sec
B7ZM01
resolver
amino_acid_sequence
MMEPEEYRERGREMVDYICQYLSTVRERRVTPDVQPGYLRAQLPESAPEDPDSWDSIFGDIERIIMPGVVHWQSPHMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNVMDWLAKMLGLPEHFLHHHPSSQGGGVLQSTVSESTLIALLAARKNKILEMKTSEPDADESCLNARLVAYASDQAHSSVEKAGLISLVKMKFLPVDDNFSLRGEALQKAIEEDKQRGLVPVFVCATLGTTGVCAFDCLSELGPICAREGLWLHIDAAYAGTAFLCPEFRGFLKGIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQTFSVNPIYLRHANSGVATDFMHWQIPLSRRFRSVKLWFVIRSFGVKNLQAHVRHGTEMAKYFESLVRNDPSFEIPAKRHLGLVVFRLKGPNCLTENVLKEIAKAGRLFLIPATIQDKLIIRFTVTSQFTTRDDILRDWNLIRDAATLILSQHCTSQPSPRVGNLISQIRGARAWACGTSLQSVSGAGDDPVQARKIIKQPQRVGAGPMKRENGLHLETLLDPVDDCFSEEAPDATKHKLSSFLFSYLSVQTKKKTVRSLSCNSVPVSAQKPLPTEASVKNGGSSRVRIFSRFPEDMMMLKKSAFKKLIKFYSVPSFPECSSQCGLQLPCCPLQAMV
uniprot
proteins
ec_number
4.1.1.22
uniprot
proteins
function
FUNCTION: Catalyzes the biosynthesis of histamine from histidine. {ECO:0000269|PubMed:22767596}.
uniprot
proteins
mass_dalton
74141
uniprot
proteins
mutagenesis
MUTAGEN 305; /note="K->G: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:22767596"; MUTAGEN 334; /note="Y->F: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:22767596"; MUTAGEN 354; /note="S->G: Strongly decreases affinity for histidine. Strongly increases affinity for L-DOPA and confers enzyme activity toward L-DOPA."; /evidence="ECO:0000269|PubMed:22767596
uniprot
proteins
pathway_participation
PATHWAY: Amine and polyamine biosynthesis; histamine biosynthesis; histamine from L-histidine: step 1/1.
uniprot
proteins
protein_family
Group II decarboxylase family
uniprot
proteins
pubmed
1425659
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
1768863
uniprot
proteins
pubmed
2216786
uniprot
proteins
pubmed
22767596
uniprot
proteins
pubmed
8288622
uniprot
proteins
sequence_length
662
uniprot
proteins