Cntfr
entrez
313173
canonical
uniprot
Q08406
canonical
ensembl
ENSRNOG00000047307
resolver
ensp
ENSRNOP00000077340
resolver
genesymbol
Cntfr
resolver
uniprot_entry
CNTFR_RAT
resolver
amino_acid_sequence
MAASVPWACCAVLAAAAAAVYTQKHSPQEAPHVQYERLGTDVTLPCGTASWDAAVTWRVNGTDLAPDLLNGSQLILRSLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNTYPKGFYCSWHLSAPTYIPNTFNVTVLHGSKMMVCEKDPALKNRCHIRYMHLFSTIKYKVSISVSNALGHNTTAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSNGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHATPWTEEPRHLTTEAQAPETTTSTTSSLAPPPTTKICDPGELSSGGGPSIPFLTSVPVTLVLAAAAATANNLLI
uniprot
proteins
function
FUNCTION: Functions either as a membrane-anchored non-signaling receptor via a GPI anchor or, after proteolytic release, as a soluble ligand-binding chaperone, and mediates signaling of CNTF-related cytokines, including ciliary neurotrophic factor (CNTF), cardiotrophin-like cytokine factor 1 (CLCF1), and the heterodimeric cytokine formed by CLCF1 and the cytokine receptor-like factor 1 (CRLF1) (PubMed:8381290). Involved namely in cell survival of motor neurons and regulation of oligodendrocyte progenitor proliferation. Functions within the ciliary neurotrophic factor receptor (CNTFR) complex as a membrane-anchored non-signaling receptor subunit associated with two other signaling receptor subunits IL6ST/gp130 and LIFR. Alternatively functions as a soluble ligand-binding chaperone that binds ligand in the extracellular space, forming a cytokine complex which is delivered to the IL6ST/gp130 and LIFR signaling receptor subunits. Mechanistically, ligand binding to the CNTFR induces dimerization of the IL6ST/gp130 and LIFR (or IL27RA/WSX1 in the case of MT-RNR2/humanin), which activate JAK tyrosine kinases (JAK1 or JAK2 and to lesser extent TYK2) bound to their intracellular domains. These kinases subsequently phosphorylate IL6ST/gp130 and LIFR (or IL27RA/WSX1). The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducer and activators of transcription (STAT3 and to lesser extent STAT1) (By similarity). {ECO:0000250|UniProtKB:P26992, ECO:0000269|PubMed:8381290}.
uniprot
proteins
mass_dalton
40822
uniprot
proteins
post_translational_modification
PTM: GPI processing by GDPD2 releases 2 soluble forms, a 100 kDa form and a 90 kDa form. In vitro, GPI processing is also mediated by a phosphatidylinositol (PI) phospholipase C (PI-PLC) releasing a soluble form of 90 kDa. The 100 kDa form is released by extracellular vesicles. {ECO:0000250|UniProtKB:P26992}.
uniprot
proteins
protein_family
Type 3 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
8381290
uniprot
proteins
pubmed
8460125
uniprot
proteins
sequence_length
372
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P26992}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P26992}. Secreted {ECO:0000250|UniProtKB:P26992}. Note=Localized at cell membrane when associated with SORL1. Released from plasma membrane and extracellular vesicles (EV) by GDPD2. {ECO:0000250|UniProtKB:P26992}.
uniprot
proteins