Cbln2
entrez
291388
canonical
uniprot
P98087
canonical
ensembl
ENSRNOG00000013654
resolver
ensembl
ENSRNOG00055012048
resolver
ensembl
ENSRNOG00060015358
resolver
ensembl
ENSRNOG00065002940
resolver
ensp
ENSRNOP00000018682
resolver
enst
ENSRNOT00000018682
resolver
genesymbol
Cbln2
resolver
uniprot
Q5BJT3
resolver
uniprot_entry
CBLN2_RAT
resolver
uniprot_sec
Q5BJT3
resolver
amino_acid_sequence
MPAPGRGPRGPLLSMPGRRGALREPADFGSSLGAALALLLLLLPACCPVKAQNDTEPIVLEGKCLVVCDSSPSGDGAVTSSLGISVRSGSAKVAFSATRSTNHEPSEMSNRTMTIYFDQVLVNIGNHFDLASSIFVAPRKGIYSFSFHVVKVYNRQTIQVSLMQNGYPVISAFAGDQDVTREAASNGVLLLMEREDKVHLKLERGNLMGGWKYSTFSGFLVFPL
uniprot
proteins
function
FUNCTION: Acts as a synaptic organizer in specific subsets of neurons in the brain. Essential for long-term maintenance but not establishment of excitatory synapses. Functions as part of a trans-synaptic complex by binding to postsynaptic GRID1 and presynaptic neurexins. This interaction helps regulate the activity of NMDA and AMPA receptors at hippocampal synapses without affecting synapse formation. NRXN1B-CBLN2-GRID1 complex transduce presynaptic signals into postsynaptic NMDAR response. NRXN3B-CBLN2-GRID1 complex transduce presynaptic signals into postsynaptic AMPAR response. {ECO:0000250|UniProtKB:Q8BGU2}.
uniprot
proteins
mass_dalton
24023
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15702230
uniprot
proteins
pubmed
1850079
uniprot
proteins
sequence_length
224
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8BGU2}.
uniprot
proteins