Alkal2
entrez
679566
canonical
uniprot
B2RZ42
canonical
ensembl
ENSRNOG00000005154
resolver
ensembl
ENSRNOG00055005868
resolver
ensembl
ENSRNOG00060008036
resolver
ensembl
ENSRNOG00065010779
resolver
ensp
ENSRNOP00000006921
resolver
ensp
ENSRNOP00055007295
resolver
ensp
ENSRNOP00060010068
resolver
ensp
ENSRNOP00065013384
resolver
enst
ENSRNOT00000006921
resolver
enst
ENSRNOT00055009481
resolver
enst
ENSRNOT00060013256
resolver
enst
ENSRNOT00065017452
resolver
genesymbol
Alkal2
resolver
uniprot_entry
ALKL2_RAT
resolver
amino_acid_sequence
MRVSGRPMLLALLLLLSTVGDPGHAQPRGPADRQTLLRLLVELVQELKKFHIGDSKRLQLLGESDFALGRREATDYGADQEEQRVEIVPRDLRMKDKFLKHLTGPLYFSPKCSKHFHRLYHNTRDCTIPAYYKRCARLLTRLAVSPMCMER
uniprot
proteins
function
FUNCTION: Cytokine that acts as a physiological ligand for receptor tyrosine kinases LTK and ALK, leading to their activation. Cytokine-binding is sufficient to activate LTK. In contrast, ALKAL2-driven activation of ALK is coupled with heparin-binding to ALK. Stimulation of ALK signaling is involved in neural development and regulation of energy expenditure. {ECO:0000250|UniProtKB:Q6UX46}.
uniprot
proteins
mass_dalton
17428
uniprot
proteins
protein_family
ALKAL family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
151
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q6UX46}. Cell membrane {ECO:0000250|UniProtKB:Q6UX46}. Note=Following interaction with receptor tyrosine kinase ALK, associates with the cell membrane, membrane-binding is required to activate ALK. {ECO:0000250|UniProtKB:Q6UX46}.
uniprot
proteins