CPSF2
entrez
53981
canonical
uniprot
Q9P2I0
canonical
ensembl
ENSG00000165934
resolver
ensp
ENSP00000298875
resolver
ensp
ENSP00000578888
resolver
ensp
ENSP00000602704
resolver
ensp
ENSP00000602705
resolver
ensp
ENSP00000602706
resolver
ensp
ENSP00000602708
resolver
ensp
ENSP00000602709
resolver
ensp
ENSP00000613868
resolver
enst
ENST00000298875
resolver
enst
ENST00000908829
resolver
enst
ENST00000932645
resolver
enst
ENST00000932646
resolver
enst
ENST00000932647
resolver
enst
ENST00000932649
resolver
enst
ENST00000932650
resolver
enst
ENST00000943809
resolver
genesymbol
CPSF2
resolver
genesymbol_syn
CPSF100
resolver
genesymbol_syn
KIAA1367
resolver
hgnc
HGNC:2325
resolver
uniprot
B3KME1
resolver
uniprot
Q6NSJ1
resolver
uniprot
Q9H3W7
resolver
uniprot_entry
CPSF2_HUMAN
resolver
uniprot_sec
B3KME1
resolver
uniprot_sec
Q6NSJ1
resolver
uniprot_sec
Q9H3W7
resolver
amino_acid_sequence
MTSIIKLTTLSGVQEESALCYLLQVDEFRFLLDCGWDEHFSMDIIDSLRKHVHQIDAVLLSHPDPLHLGALPYAVGKLGLNCAIYATIPVYKMGQMFMYDLYQSRHNTEDFTLFTLDDVDAAFDKIQQLKFSQIVNLKGKGHGLSITPLPAGHMIGGTIWKIVKDGEEEIVYAVDFNHKREIHLNGCSLEMLSRPSLLITDSFNATYVQPRRKQRDEQLLTNVLETLRGDGNVLIAVDTAGRVLELAQLLDQIWRTKDAGLGVYSLALLNNVSYNVVEFSKSQVEWMSDKLMRCFEDKRNNPFQFRHLSLCHGLSDLARVPSPKVVLASQPDLECGFSRDLFIQWCQDPKNSIILTYRTTPGTLARFLIDNPSEKITEIELRKRVKLEGKELEEYLEKEKLKKEAAKKLEQSKEADIDSSDESDIEEDIDQPSAHKTKHDLMMKGEGSRKGSFFKQAKKSYPMFPAPEERIKWDEYGEIIKPEDFLVPELQATEEEKSKLESGLTNGDEPMDQDLSDVPTKCISTTESIEIKARVTYIDYEGRSDGDSIKKIINQMKPRQLIIVHGPPEASQDLAECCRAFGGKDIKVYMPKLHETVDATSETHIYQVRLKDSLVSSLQFCKAKDAELAWIDGVLDMRVSKVDTGVILEEGELKDDGEDSEMQVEAPSDSSVIAQQKAMKSLFGDDEKETGEESEIIPTLEPLPPHEVPGHQSVFMNEPRLSDFKQVLLREGIQAEFVGGVLVCNNQVAVRRTETGRIGLEGCLCQDFYRIRDLLYEQYAIV
uniprot
proteins
function
FUNCTION: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Involved in the histone 3' end pre-mRNA processing. {ECO:0000269|PubMed:14749727, ECO:0000269|PubMed:18688255}.
uniprot
proteins
mass_dalton
88487
uniprot
proteins
mutagenesis
MUTAGEN 67; /note="H->A: Inhibits histone 3'-end processing."; /evidence="ECO:0000269|PubMed:18688255"; MUTAGEN 289; /note="D->A: Does not inhibit histone 3'-end processing."; /evidence="ECO:0000269|PubMed:18688255"; MUTAGEN 543; /note="R->A: Inhibits histone 3'-end processing."; /evidence="ECO:0000269|PubMed:18688255
uniprot
proteins
protein_family
CPSF2/YSH1 subfamily
uniprot
proteins
protein_family
Metallo-beta-lactamase superfamily
uniprot
proteins
protein_family
RNA-metabolizing metallo-beta-lactamase-like family
uniprot
proteins
pubmed
10718198
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14749727
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18688255
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21102410
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
782
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins