Mylk2
entrez
117558
canonical
uniprot
P20689
canonical
ensembl
ENSRNOG00000008235
resolver
ensp
ENSRNOP00000011255
resolver
enst
ENSRNOT00000011255
resolver
genesymbol
Mylk2
resolver
uniprot
G3V731
resolver
uniprot_entry
G3V731_RAT
resolver
uniprot_entry
MYLK2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by Ca(2+) via calmodulin. Binding of four Ca(2+) ions enables formation of a Ca(2+)-calmodulin-kinase complex that stimulates catalytic activity. Mg(2+) competitively inhibits activation by opposing Ca(2+) binding. {ECO:0000250|UniProtKB:P07313}.
uniprot
proteins
amino_acid_sequence
MATENGAVELGTQSLSTDHPPTDAAGDGSPASEKEPSLPDTEKDLGPTNTKKDPGAPDPKKNPDPPSLKKTPEAPGPEKKGDSAPASASNQGPSGEGDGGGGPAEGGTGPPAVLPQPTATADASIQKLDATQAPSGNQESGEAKAGKKAAECREAGRRGSPAFLHSPSCPAIISCSEKTLAMKPLSETTELIFAGVSETPDPQDPGPAKDEGGTNTLADGKEEAEAGQAEQAKVQGDTSQRIGFQAVPSERAEVGQALCLTAKEEDCFQILDDCPPPPAPFPHRIVELRTGNVSSEFSMNSKEALGGGKFGAVCTCTERSTGLKLAAKVIKKQTPKDKEMVLLEIEVMNQLNHRNLIQLYSAIETSHEIILFMEYIEGGELFERIVDEDYQLTEVDTMVFVRQICDGILFMHKMRVLHLDLKPENILCVNTTGHLVKIIDFGLARRYNPNEKLKVNFGTPEFLSPEVVNYDQISDKTDMWSLGVITYMLLSGLSPFLGDDDTETLNNVLSANWYFDEETFEAVSDEAKDFVSNLITKDQSARMSAEQCLAHPWLNNLAEKAKRCNRRLKSQILLKKYLMKRRWKKNFIAVSAANRFKKISSSGALMALGV
uniprot
proteins
ec_number
2.7.11.18
uniprot
proteins
function
FUNCTION: Ca(2+)/calmodulin-dependent kinase that phosphorylates the regulatory light chain (RLC) of sarcomeric myosin in skeletal and cardiac muscle. Phosphorylation of RLC promotes displacement of myosin cross-bridges from the thick filament backbone toward actin-containing thin filaments, increasing the probability of cross-bridge entry into force-generating states and thereby potentiating contractile force at submaximal Ca(2+) concentrations. {ECO:0000250|UniProtKB:P07313, ECO:0000250|UniProtKB:Q8VCR8}.
uniprot
proteins
mass_dalton
65816
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2465691
uniprot
proteins
pubmed
2839493
uniprot
proteins
sequence_length
610
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Colocalizes with phosphorylated myosin light chain (RLCP) at filaments of the myofibrils. {ECO:0000250}.
uniprot
proteins