AKAP19
entrez
84281
canonical
uniprot
Q9BSF0
canonical
ensembl
ENSG00000187699
resolver
ensp
ENSP00000345107
resolver
ensp
ENSP00000380172
resolver
ensp
ENSP00000386649
resolver
ensp
ENSP00000405225
resolver
ensp
ENSP00000540711
resolver
ensp
ENSP00000540712
resolver
ensp
ENSP00000540713
resolver
ensp
ENSP00000540714
resolver
ensp
ENSP00000587930
resolver
ensp
ENSP00000587931
resolver
ensp
ENSP00000618443
resolver
ensp
ENSP00000618444
resolver
ensp
ENSP00000760727
resolver
ensp
ENSP00000760730
resolver
enst
ENST00000340623
resolver
enst
ENST00000396974
resolver
enst
ENST00000409870
resolver
enst
ENST00000443551
resolver
enst
ENST00000870652
resolver
enst
ENST00000870653
resolver
enst
ENST00000870654
resolver
enst
ENST00000870655
resolver
enst
ENST00000917871
resolver
enst
ENST00000917872
resolver
enst
ENST00000948384
resolver
enst
ENST00000948385
resolver
genesymbol
AKAP19
resolver
genesymbol_syn
C2orf88
resolver
hgnc
HGNC:28191
resolver
uniprot
D3DPI3
resolver
uniprot
P0C876
resolver
uniprot
Q53TC7
resolver
uniprot_entry
SMAKA_HUMAN
resolver
uniprot_sec
D3DPI3
resolver
uniprot_sec
P0C876
resolver
uniprot_sec
Q53TC7
resolver
amino_acid_sequence
MGCMKSKQTFPFPTIYEGEKQHESEEPFMPEERCLPRMASPVNVKEEVKEPPGTNTVILEYAHRLSQDILCDALQQWACNNIKYHDIPYIESEGP
uniprot
proteins
function
FUNCTION: Binds to type I regulatory subunits of protein kinase A (PKA-RI) and anchors/targets them to the plasma membrane. {ECO:0000269|PubMed:23115245, ECO:0000269|PubMed:27028580}.
uniprot
proteins
mass_dalton
10970
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="G->A: Loss of plasma membrane localization."; /evidence="ECO:0000269|PubMed:23115245"; MUTAGEN 3; /note="C->A: Loss of plasma membrane localization."; /evidence="ECO:0000269|PubMed:23115245"; MUTAGEN 66; /note="S->D: Phosphomimetic mutant. Abolishes interaction with PRKAR1A and PRKAR1B resulting in the loss of their plasma membrane localization."; /evidence="ECO:0000269|PubMed:27028580"; MUTAGEN 66; /note="S->E: Phosphomimetic mutant. Abolishes interaction with PRKAR1A and PRKAR1B resulting in the loss of their plasma membrane localization."; /evidence="ECO:0000269|PubMed:27028580
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-66 by PKA disrupts interaction with PRKAR1A and PRKAR1B, resulting in loss of their plasma membrane localization. {ECO:0000269|PubMed:27028580}.; PTM: May be palmitoylated at Cys-3. {ECO:0000269|PubMed:23115245}.
uniprot
proteins
protein_family
Small membrane AKAP family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
23115245
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
27028580
uniprot
proteins
sequence_length
95
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23115245, ECO:0000269|PubMed:27028580}. Note=The GFP-tagged protein has been detected at the plasma membrane, enriched in filopodia and cell-cell junctions. {ECO:0000269|PubMed:23115245}.
uniprot
proteins