Eomes
entrez
13813
canonical
uniprot
O54839
canonical
ensembl
ENSMUSG00000032446
resolver
ensp
ENSMUSP00000035020
resolver
ensp
ENSMUSP00000107393
resolver
ensp
ENSMUSP00000325603
resolver
genesymbol
Eomes
resolver
genesymbol_syn
Tbr2
resolver
uniprot
Q3UPL1
resolver
uniprot
Q52KJ1
resolver
uniprot
Q8BN22
resolver
uniprot
Q9JJL1
resolver
uniprot
Q9QYG7
resolver
uniprot_entry
EOMES_MOUSE
resolver
uniprot_sec
Q3UPL1
resolver
uniprot_sec
Q52KJ1
resolver
uniprot_sec
Q8BN22
resolver
uniprot_sec
Q9JJL1
resolver
uniprot_sec
Q9QYG7
resolver
amino_acid_sequence
MQLGEQLLVSSVNLPGAHFYSLESARGGGGGGGGGGGGGGGSVSLLPGAAPSPQRLDLDKASKKFPGSLPCQAGSAEPAGAGAGAPAAMLSDADAGDTFGSTSAVAKPGPPDGRKGSPCAEEELPSAATAAATARYSMDSLSSERYYLPSPGPQGSELAAPCSLFQYPAAAGAAHGPVYPASNGARYPYGSMLPPGGFPAAVCPPARAQFGPAAGSGSGAGSSGGGAGGPGAYPYGQGSPLYGPYAGTSAAGSCGGLGGLGVPGSGFRAHVYLCNRPLWLKFHRHQTEMIITKQGRRMFPFLSFNINGLNPTAHYNVFVEVVLADPNHWRFQGGKWVTCGKADNNMQGNKMYVHPESPNTGSHWMRQEISFGKLKLTNNKGANNNNTQMIVLQSLHKYQPRLHIVEVTEDGVEDLNEPSKTQTFTFSETQFIAVTAYQNTDITQLKIDHNPFAKGFRDNYDSMYTASENDRLTPSPTDSPRSHQIVPGGRYGVQNFFPEPFVNTLPQARYYNGERTVPQTNGLLSPQQSEEVANPPQRWLVTPVQQPVTNKLDIGSYESEYTSSTLLPYGIKSLPLQTSHALGYYPDPTFPAMAGWGGRGAYQRKMAAGLPWTSRMSPPVFPEDQLAKEKVKEEISSSWIETPPSIKSLDSSDSGVYNSACKRKRLSPSTPSNGNSPPIKCEDINTEEYSKDTSKGMGAYYAFYTSP
uniprot
proteins
function
FUNCTION: Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification (PubMed:10716450). Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex (PubMed:18171685, PubMed:18940588). Required for differentiation and migration of unipolar dendritic brush cells (PubMed:33488348). Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes (PubMed:14605368). {ECO:0000269|PubMed:10716450, ECO:0000269|PubMed:14605368, ECO:0000269|PubMed:18171685, ECO:0000269|PubMed:18940588, ECO:0000269|PubMed:33488348}.
uniprot
proteins
mass_dalton
74801
uniprot
proteins
pubmed
10407135
uniprot
proteins
pubmed
10716450
uniprot
proteins
pubmed
10974533
uniprot
proteins
pubmed
14605368
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18171685
uniprot
proteins
pubmed
18940588
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
33488348
uniprot
proteins
pubmed
9503012
uniprot
proteins
sequence_length
707
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins