Ccr5
entrez
117029
canonical
uniprot
O08556
canonical
ensembl
ENSRNOG00000049115
resolver
ensembl
ENSRNOG00055002419
resolver
ensembl
ENSRNOG00060023387
resolver
ensembl
ENSRNOG00065000760
resolver
ensp
ENSRNOP00000073121
resolver
ensp
ENSRNOP00055002890
resolver
ensp
ENSRNOP00060033465
resolver
ensp
ENSRNOP00065000790
resolver
enst
ENSRNOT00000082774
resolver
enst
ENSRNOT00055003842
resolver
enst
ENSRNOT00060040498
resolver
enst
ENSRNOT00065001050
resolver
genesymbol
Ccr5
resolver
genesymbol_syn
Cmkbr5
resolver
uniprot
A0A0G2K4P3
resolver
uniprot
Q68G28
resolver
uniprot_entry
A0A0G2K4P3_RAT
resolver
uniprot_entry
CCR5_RAT
resolver
uniprot_entry
Q68G28_RAT
resolver
amino_acid_sequence
MDFQGSIPTYIYDIDYSMSAPCQKVNVKQIAAQLLPPLYSLVFIFGFVGNMMVFLILISCKKLKSMTDIYLFNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKLFTGIYHIGYFGGIFFIILLTIDRYLAIVHAVFAIKARTVNFGVITSVVTWVVAVFVSLPEIIFMRSQKEGSHYTCSPHFLHIQYRFWKHFQTLKMVILSLILPLLVMVICYSGILNTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLLLTTFQEYFGLNNCSSSNRLDQAMQVTETLGMTHCCLNPVIYAFVGEKFRNYLSVFFRKHIVKRFCKHCSIFQQVNPDRVSSVYTRSTGEQEVSTGL
uniprot
proteins
function
FUNCTION: Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor. {ECO:0000250|UniProtKB:P51681}.
uniprot
proteins
mass_dalton
41031
uniprot
proteins
post_translational_modification
PTM: Sulfated on at least 2 of the N-terminal tyrosines. Sulfation is required for efficient binding of the chemokines, CCL3 and CCL4 (By similarity). {ECO:0000250|UniProtKB:P51681}.; PTM: O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site. Also sialylated glycans present which contribute to chemokine binding. Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen (By similarity). {ECO:0000250|UniProtKB:P51681}.; PTM: Palmitoylation in the C-terminal is important for cell surface expression. {ECO:0000250|UniProtKB:P51681}.; PTM: Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES. {ECO:0000250|UniProtKB:P51681}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
9655467
uniprot
proteins
pubmed
9670989
uniprot
proteins
sequence_length
354
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 33..60; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 71..91; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 105..126; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 144..168; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 201..220; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 238..262; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 280..303; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins