Cnmd
entrez
81512
canonical
uniprot
O70367
canonical
ensembl
ENSRNOG00000012821
resolver
ensp
ENSRNOP00000017400
resolver
enst
ENSRNOT00000017400
resolver
genesymbol
Cnmd
resolver
genesymbol_syn
Chmi
resolver
genesymbol_syn
Lect1
resolver
uniprot
F7EQ36
resolver
uniprot_entry
CNMD_RAT
resolver
uniprot_entry
F7EQ36_RAT
resolver
amino_acid_sequence
MTENSDKVPITMVGPEDVEFCSPPAYATVTVKPSGSPTRLLKVGAVVLISGAVLLLFGAIGAFYFWKGNDNHIYNVHYTMSINGRLQDASMEIDAANNLETFKMGSGAEEAIEVNDFQNGITGIRFAGGEKCYIKAQVKARIPEVSTGTKQSISELEGKIMPVKYEENSLIWVAVDQPVKDNSFLSSKILEFCGDLPIFWLKPMYPKEIPRERREVVRSSAPSTTRRPHSEPRGNAGPGRLSNRTRPSVQDDEEPFNPDNPYHQQEGESMTFDPRLDHEGICCIECRRSYTHCQKICEPLGGYYPWPYNYQGCRSACRVVMPCSWWVARILGMV
uniprot
proteins
function
FUNCTION: Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
37387
uniprot
proteins
post_translational_modification
PTM: After cleavage, the post-translationally modified ChM-I is secreted as a glycoprotein. {ECO:0000250}.
uniprot
proteins
protein_family
Chondromodulin-1 family
uniprot
proteins
pubmed
11328727
uniprot
proteins
pubmed
16980969
uniprot
proteins
sequence_length
334
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Chondromodulin-1]: Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=Accumulated in the inter-territorial matrix of cartilage. {ECO:0000250}.; SUBCELLULAR LOCATION: [Chondrosurfactant protein]: Endomembrane system {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 46..66; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins