Cd247
entrez
12503
canonical
uniprot
P24161
canonical
ensembl
ENSMUSG00000005763
resolver
ensp
ENSMUSP00000005907
resolver
ensp
ENSMUSP00000027849
resolver
ensp
ENSMUSP00000124297
resolver
ensp
ENSMUSP00000124299
resolver
ensp
ENSMUSP00000268139
resolver
enst
ENSMUST00000161559
resolver
enst
ENSMUST00000161971
resolver
genesymbol
Cd247
resolver
genesymbol_syn
Cd3z
resolver
genesymbol_syn
Tcrz
resolver
uniprot
A0ACM8QBV2
resolver
uniprot
A2MZG6
resolver
uniprot
E7EXC2
resolver
uniprot
F6TGD8
resolver
uniprot
P29020
resolver
uniprot
Q3UU54
resolver
uniprot
Q9D3G3
resolver
uniprot_entry
A0ACM8QBV2_MOUSE
resolver
uniprot_entry
A2MZG6_MOUSE
resolver
uniprot_entry
CD3Z_MOUSE
resolver
uniprot_entry
F6TGD8_MOUSE
resolver
uniprot_entry
Q3UU54_MOUSE
resolver
uniprot_sec
E7EXC2
resolver
uniprot_sec
P29020
resolver
uniprot_sec
Q9D3G3
resolver
amino_acid_sequence
MKWKVSVLACILHVRFPGAEAQSFGLLDPKLCYLLDGILFIYGVIITALYLRAKFSRSAETAANLQDPNQLYNELNLGRREEYDVLEKKRARDPEMGGKQQRRRNPQEGVYNALQKDKMAEAYSEIGTKGERRRGKGHDGLYQGLSTATKDTYDALHMQTLAPR
uniprot
proteins
function
FUNCTION: Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD247/CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. CD247/CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme. Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN). {ECO:0000250|UniProtKB:P20963, ECO:0000269|PubMed:20188655, ECO:0000269|PubMed:8223495}.
uniprot
proteins
mass_dalton
18637
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8. {ECO:0000269|PubMed:9575182}.
uniprot
proteins
protein_family
CD3Z/FCER1G family
uniprot
proteins
pubmed
10662792
uniprot
proteins
pubmed
11891219
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1828894
uniprot
proteins
pubmed
20188655
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2139725
uniprot
proteins
pubmed
2150596
uniprot
proteins
pubmed
2787796
uniprot
proteins
pubmed
3278377
uniprot
proteins
pubmed
8223495
uniprot
proteins
pubmed
9575182
uniprot
proteins
sequence_length
164
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9575182}; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 31..51; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins