ACAA2
entrez
10449
canonical
uniprot
P42765
canonical
ensembl
ENSG00000167315
resolver
ensp
ENSP00000285093
resolver
enst
ENST00000285093
resolver
genesymbol
ACAA2
resolver
hgnc
HGNC:83
resolver
uniprot
B3KNP8
resolver
uniprot
Q9BUT6
resolver
uniprot_entry
B3KNP8_HUMAN
resolver
uniprot_entry
THIM_HUMAN
resolver
uniprot_sec
Q9BUT6
resolver
amino_acid_sequence
MALLRGVFVVAAKRTPFGAYGGLLKDFTATDLSEFAAKAALSAGKVSPETVDSVIMGNVLQSSSDAIYLARHVGLRVGIPKETPALTINRLCGSGFQSIVNGCQEICVKEAEVVLCGGTESMSQAPYCVRNVRFGTKLGSDIKLEDSLWVSLTDQHVQLPMAMTAENLAVKHKISREECDKYALQSQQRWKAANDAGYFNDEMAPIEVKTKKGKQTMQVDEHARPQTTLEQLQKLPPVFKKDGTVTAGNASGVADGAGAVIIASEDAVKKHNFTPLARIVGYFVSGCDPSIMGIGPVPAISGALKKAGLSLKDMDLVEVNEAFAPQYLAVERSLDLDISKTNVNGGAIALGHPLGGSGSRITAHLVHELRRRGGKYAVGSACIGGGQGIAVIIQSTA
uniprot
proteins
ec_number
2.3.1.16
uniprot
proteins
ec_number
2.3.1.9
uniprot
proteins
ec_number
3.1.2.-
uniprot
proteins
ec_number
3.1.2.1
uniprot
proteins
ec_number
3.1.2.2
uniprot
proteins
function
FUNCTION: In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable). Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable). Also displays hydrolase activity on various fatty acyl-CoAs (PubMed:25478839). Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable). Abolishes BNIP3-mediated apoptosis and mitochondrial damage (PubMed:18371312). {ECO:0000269|PubMed:18371312, ECO:0000269|PubMed:25478839, ECO:0000305|PubMed:25478839}.
uniprot
proteins
mass_dalton
41924
uniprot
proteins
mutagenesis
MUTAGEN 92; /note="C->A: Decreased acyl-CoA hydrolase activity."; /evidence="ECO:0000269|PubMed:25478839"; MUTAGEN 92; /note="C->S: Decreased acyl-CoA hydrolase activity; when associated with A-382."; /evidence="ECO:0000269|PubMed:25478839"; MUTAGEN 382; /note="C->S: Decreased acyl-CoA hydrolase activity; when associated with S-92."; /evidence="ECO:0000269|PubMed:25478839
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid beta-oxidation. {ECO:0000269|PubMed:25478839}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the SCF(FBXO42) complex; leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q8BWT1}.
uniprot
proteins
protein_family
Thiolase family
uniprot
proteins
protein_family
Thiolase-like superfamily
uniprot
proteins
pubmed
15242332
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18371312
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25478839
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
8241273
uniprot
proteins
sequence_length
397
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:18371312}.
uniprot
proteins