ACY3
entrez
91703
canonical
uniprot
Q96HD9
canonical
ensembl
ENSG00000132744
resolver
ensp
ENSP00000255082
resolver
ensp
ENSP00000434270
resolver
ensp
ENSP00000567183
resolver
ensp
ENSP00000567184
resolver
ensp
ENSP00000567185
resolver
ensp
ENSP00000567187
resolver
ensp
ENSP00000567188
resolver
ensp
ENSP00000567189
resolver
ensp
ENSP00000567190
resolver
enst
ENST00000255082
resolver
enst
ENST00000529256
resolver
enst
ENST00000897124
resolver
enst
ENST00000897125
resolver
enst
ENST00000897126
resolver
enst
ENST00000897128
resolver
enst
ENST00000897129
resolver
enst
ENST00000897130
resolver
enst
ENST00000897131
resolver
genesymbol
ACY3
resolver
genesymbol_syn
ASPA2
resolver
hgnc
HGNC:24104
resolver
uniprot
E9PRA7
resolver
uniprot_entry
ACY3_HUMAN
resolver
uniprot_entry
E9PRA7_HUMAN
resolver
amino_acid_sequence
MCSLPVPREPLRRVAVTGGTHGNEMSGVYLARHWLHAPAELQRASFSAVPVLANPAATSGCRRYVDHDLNRTFTSSFLNSRPTPDDPYEVTRARELNQLLGPKASGQAFDFVLDLHNTTANMGTCLIAKSSHEVFAMHLCRHLQLQYPELSCQVFLYQRSGEESYNLDSVAKNGLGLELGPQPQGVLRADIFSRMRTLVATVLDFIELFNQGTAFPAFEMEAYRPVGVVDFPRTEAGHLAGTVHPQLQDRDFQPLQPGAPIFQMFSGEDLLYEGESTVYPVFINEAAYYEKGVAFVQTEKFTFTVPAMPALTPAPSPAS
uniprot
proteins
ec_number
3.5.1.114
uniprot
proteins
function
FUNCTION: Deacetylates N-acetyl aromatic amino acids and mercapturic acids (N-acetyl-L-cysteine-S-conjugates), including halogenated mercapturic acids derived from the metabolism of environmental contaminants such as trichloroethylene, making it a key enzyme in the processing of both endogenous and xenobiotic compounds. In neurons and blood vessels, deacetylates the mercapturates of 4-hydroxy-2-nonenal (4HNE) and acrolein (ACR), two highly reactive lipid peroxidation products; the resulting deacetylated products can then be transformed into toxic compounds by beta-lyase. {ECO:0000250|UniProtKB:Q91XE4}.
uniprot
proteins
mass_dalton
35241
uniprot
proteins
protein_family
AspA/AstE family
uniprot
proteins
protein_family
Aspartoacylase subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19486448
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
319
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q91XE4}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q91XE4}. Cytoplasm {ECO:0000250|UniProtKB:Q91XE4}. Note=Predominantly localized in the apical membrane of cells in the S1 segment. In the proximal straight tubules (S2 and S3 segments) is expressed diffusely throughout the cytoplasm. {ECO:0000250|UniProtKB:Q91XE4}.
uniprot
proteins