Cpsf3
entrez
54451
canonical
uniprot
Q9QXK7
canonical
ensembl
ENSMUSG00000054309
resolver
ensp
ENSMUSP00000068148
resolver
ensp
ENSMUSP00000152703
resolver
enst
ENSMUST00000067284
resolver
enst
ENSMUST00000222968
resolver
genesymbol
Cpsf3
resolver
genesymbol_syn
Cpsf73
resolver
uniprot
A0A1Y7VLY3
resolver
uniprot
Q3UDS1
resolver
uniprot
Q8CIM0
resolver
uniprot_entry
A0A1Y7VLY3_MOUSE
resolver
uniprot_entry
CPSF3_MOUSE
resolver
uniprot_entry
Q3UDS1_MOUSE
resolver
uniprot_sec
Q8CIM0
resolver
amino_acid_sequence
MSAIPAEESDQLLIRPLGAGQEVGRSCIILEFKGRKIMLDCGIHPGLEGMDALPYIDLIDPAEIDLLLISHFHLDHCGALPWFLQKTSFKGRTFMTHATKAIYRWLLSDYVKVSNISADDMLYTETDLEESMDKIETINFHEVKEVAGIKFWCYHAGHVLGAAMFMIEIAGVKLLYTGDFSRQEDRHLMAAEIPNIKPDILIIESTYGTHIHEKREEREARFCNTVHDIVNRGGRGLIPVFALGRAQELLLILDEYWQNHPELHDIPIYYASSLAKKCMAVYQTYVNAMNDKIRKQININNPFVFKHISNLKSMDHFDDIGPSVVMASPGMIQNGLSRELFESWCTDKRNGVIIAGYCVEGTLAKHIMSEPEEITTMSGQKLPLKMSVDYISFSAHTDYQQTSEFIRALKPPHVILVHGEQNEMARLKAALIREYEDNDEVHIEVHNPRNTEAVTLNFRGEKLAKVMGFLADKKPEQGQRVSGILVKRNFNYHILSPCDLSNYTDLAMSTVKQTQAIPYTGPFYLLYYQLQKLTGDVEELEIQEKPALKVFKSITVVQEPGMVVLEWLANPSNDMYADTVTTVILEVQSNPKIRKGAVQKVSKKLEMHVYSKRLEVMLQDIFGEDCVSVKDDSVLSVTVDGKTANINLETRAVECEEGSEDDESLREMVELAAQRLYEALTPVH
uniprot
proteins
ec_number
3.1.27.-
uniprot
proteins
function
FUNCTION: Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. Has endonuclease activity, and functions as an mRNA 3'-end-processing endonuclease. Also involved in the histone 3'-end pre-mRNA processing. U7 snRNP-dependent protein that induces both the 3' endoribonucleolytic cleavage of histone pre-mRNAs and acts as a 5' to 3' exonuclease for degrading the subsequent downstream cleavage product (DCP) of mature histone mRNAs. Cleavage occurs after the 5'-ACCCA-3' sequence in the histone pre-mRNA leaving a 3'hydroxyl group on the upstream fragment containing the stem loop (SL) and 5' phosphate on the downstream cleavage product (DCP) starting with CU nucleotides. The U7-dependent 5' to 3' exonuclease activity is processive and degrades the DCP RNA substrate even after complete removal of the U7-binding site. Binds to the downstream cleavage product (DCP) of histone pre-mRNAs and the cleaved DCP RNA substrate in a U7 snRNP dependent manner. Required for the selective processing of microRNAs (miRNAs) during embryonic stem cell differentiation via its interaction with ISY1 (PubMed:26255770, PubMed:29804889). Required for entering/progressing through S-phase of the cell cycle (By similarity). Required for the biogenesis of all miRNAs from the pri-miR-17-92 primary transcript except miR-92a (PubMed:26255770). Only required for the biogenesis of miR-290 and miR-96 from the pri-miR-290-295 and pri-miR-96-183 primary transcripts, respectively (PubMed:29804889). {ECO:0000250|UniProtKB:Q9UKF6, ECO:0000269|PubMed:16213211, ECO:0000269|PubMed:18955505, ECO:0000269|PubMed:19470752, ECO:0000269|PubMed:26255770, ECO:0000269|PubMed:29804889}.
uniprot
proteins
mass_dalton
77505
uniprot
proteins
mutagenesis
MUTAGEN 75..76; /note="DH->KA: Abolishes cleavage of the 5' autoinhibitory fragment of the long primary miRNA transcript, pri-miR-17-92."; /evidence="ECO:0000269|PubMed:26255770
uniprot
proteins
post_translational_modification
PTM: Sumoylated on Lys-462, Lys-465 and Lys-545, preferentially by SUMO3. {ECO:0000250|UniProtKB:Q9UKF6}.
uniprot
proteins
protein_family
CPSF3 subfamily
uniprot
proteins
protein_family
Metallo-beta-lactamase superfamily
uniprot
proteins
protein_family
RNA-metabolizing metallo-beta-lactamase-like family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16115198
uniprot
proteins
pubmed
16213211
uniprot
proteins
pubmed
18955505
uniprot
proteins
pubmed
19470752
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26255770
uniprot
proteins
pubmed
29804889
uniprot
proteins
sequence_length
684
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UKF6}.
uniprot
proteins