KLRC2
entrez
3822
canonical
uniprot
P26717
canonical
ensembl
ENSG00000205809
resolver
ensp
ENSP00000371327
resolver
enst
ENST00000381902
resolver
genesymbol
KLRC2
resolver
genesymbol_syn
NKG2C
resolver
hgnc
HGNC:6375
resolver
uniprot
O43802
resolver
uniprot
Q52M74
resolver
uniprot
Q9NR42
resolver
uniprot_entry
NKG2C_HUMAN
resolver
uniprot_sec
O43802
resolver
uniprot_sec
Q52M74
resolver
uniprot_sec
Q9NR42
resolver
amino_acid_sequence
MNKQRGTFSEVSLAQDPKRQQRKPKGNKSSISGTEQEIFQVELNLQNPSLNHQGIDKIYDCQGLLPPPEKLTAEVLGIICIVLMATVLKTIVLIPFLEQNNFSPNTRTQKARHCGHCPEEWITYSNSCYYIGKERRTWEESLLACTSKNSSLLSIDNEEEMKFLASILPSSWIGVFRNSSHHPWVTINGLAFKHKIKDSDNAELNCAVLQVNRLKSAQCGSSMIYHCKHKL
uniprot
proteins
function
FUNCTION: Immune activating receptor involved in self-nonself discrimination. In complex with KLRD1 on cytotoxic lymphocyte subsets, recognizes non-classical major histocompatibility (MHC) class Ib HLA-E loaded with signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules, likely playing a role in the generation and effector functions of adaptive natural killer (NK) cells and in maternal-fetal tolerance during pregnancy (PubMed:30134159, PubMed:37264229, PubMed:9754572). Regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection (PubMed:20952657, PubMed:21825173). Upon HLA-E-peptide binding, transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation (PubMed:15940674, PubMed:9655483). {ECO:0000269|PubMed:15940674, ECO:0000269|PubMed:20952657, ECO:0000269|PubMed:21825173, ECO:0000269|PubMed:30134159, ECO:0000269|PubMed:37264229, ECO:0000269|PubMed:9655483, ECO:0000269|PubMed:9754572}.
uniprot
proteins
mass_dalton
26159
uniprot
proteins
mutagenesis
MUTAGEN 89; /note="K->L: Impairs the expression of KLRD1-KLRC2 on the cell surface."; /evidence="ECO:0000269|PubMed:9655483"; MUTAGEN 165..168; /note="ASIL->SIIS: Increases the affinity for HLA-E to a value similar to that observed for HLA-E-KLRD1-KLRC1 complex."; /evidence="ECO:0000269|PubMed:18083576
uniprot
proteins
pubmed
11751968
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15940674
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
18083576
uniprot
proteins
pubmed
2007850
uniprot
proteins
pubmed
20890284
uniprot
proteins
pubmed
20952657
uniprot
proteins
pubmed
21825173
uniprot
proteins
pubmed
30134159
uniprot
proteins
pubmed
37264229
uniprot
proteins
pubmed
9486650
uniprot
proteins
pubmed
9655483
uniprot
proteins
pubmed
9683661
uniprot
proteins
pubmed
9754572
uniprot
proteins
sequence_length
231
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20952657, ECO:0000269|PubMed:21825173}; Single-pass type II membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 71..93; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins