RCHY1
entrez
25898
canonical
uniprot
Q96PM5
canonical
ensembl
ENSG00000163743
resolver
ensp
ENSP00000321239
resolver
ensp
ENSP00000370220
resolver
ensp
ENSP00000421084
resolver
ensp
ENSP00000423976
resolver
ensp
ENSP00000424472
resolver
genesymbol
RCHY1
resolver
genesymbol_syn
ARNIP
resolver
genesymbol_syn
CHIMP
resolver
genesymbol_syn
PIRH2
resolver
genesymbol_syn
RNF199
resolver
genesymbol_syn
ZNF363
resolver
hgnc
HGNC:17479
resolver
uniprot
B3KRG3
resolver
uniprot
C7E541
resolver
uniprot
C7E542
resolver
uniprot
C7E543
resolver
uniprot
D3YRV2
resolver
uniprot
E7EMC8
resolver
uniprot
E7ETW5
resolver
uniprot
J3KPI0
resolver
uniprot
Q2KN33
resolver
uniprot
Q59GN7
resolver
uniprot
Q86X26
resolver
uniprot
Q96PR5
resolver
uniprot_entry
ZN363_HUMAN
resolver
uniprot_sec
B3KRG3
resolver
uniprot_sec
C7E541
resolver
uniprot_sec
C7E542
resolver
uniprot_sec
C7E543
resolver
uniprot_sec
D3YRV2
resolver
uniprot_sec
E7EMC8
resolver
uniprot_sec
E7ETW5
resolver
uniprot_sec
J3KPI0
resolver
uniprot_sec
Q2KN33
resolver
uniprot_sec
Q59GN7
resolver
uniprot_sec
Q86X26
resolver
uniprot_sec
Q96PR5
resolver
amino_acid_sequence
MAATAREDGASGQERGQRGCEHYDRGCLLKAPCCDKLYTCRLCHDNNEDHQLDRFKVKEVQCINCEKIQHAQQTCEECSTLFGEYYCDICHLFDKDKKQYHCENCGICRIGPKEDFFHCLKCNLCLAMNLQGRHKCIENVSRQNCPICLEDIHTSRVVAHVLPCGHLLHRTCYEEMLKEGYRCPLCMHSALDMTRYWRQLDDEVAQTPMPSEYQNMTVDILCNDCNGRSTVQFHILGMKCKICESYNTAQAGGRRISLDQQ
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins, including p53/TP53, TP73, HDAC1 and CDKN1B (PubMed:16914734, PubMed:17721809, PubMed:18006823, PubMed:19043414, PubMed:19483087, PubMed:21994467). Mediates ubiquitination and degradation of p53/TP53; preferentially acts on tetrameric p53/TP53 (PubMed:19043414, PubMed:19483087). Catalyzes monoubiquitinates the translesion DNA polymerase POLH (PubMed:21791603). Involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: RCHY1 acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation (PubMed:33909987). {ECO:0000269|PubMed:16914734, ECO:0000269|PubMed:17721809, ECO:0000269|PubMed:18006823, ECO:0000269|PubMed:19043414, ECO:0000269|PubMed:19483087, ECO:0000269|PubMed:21791603, ECO:0000269|PubMed:21994467, ECO:0000269|PubMed:33909987}.; FUNCTION: [Isoform 4]: Has no E3 ubiquitin-protein ligase activity. {ECO:0000269|PubMed:20452352}.
uniprot
proteins
mass_dalton
30110
uniprot
proteins
mutagenesis
MUTAGEN 176; /note="M->E: Abolishes E3 ubiquitin-protein ligase activity."; /evidence="ECO:0000269|PubMed:19043414, ECO:0000269|PubMed:33909987"; MUTAGEN 186; /note="C->A: Abolishes E3 ubiquitin-protein ligase activity."; /evidence="ECO:0000269|PubMed:19043414
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:16914734, ECO:0000269|PubMed:17721809, ECO:0000269|PubMed:18006823, ECO:0000269|PubMed:19043414, ECO:0000269|PubMed:19483087, ECO:0000269|PubMed:21994467, ECO:0000269|PubMed:33909987}.
uniprot
proteins
post_translational_modification
PTM: Subject to ubiquitination and proteasomal degradation. Interaction with PLAGL2 or KAT5 enhances protein stability. {ECO:0000269|PubMed:14701804, ECO:0000269|PubMed:19483087}.
uniprot
proteins
pubmed
14701804
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15781263
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16914734
uniprot
proteins
pubmed
17721809
uniprot
proteins
pubmed
17950244
uniprot
proteins
pubmed
18006823
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19043414
uniprot
proteins
pubmed
19483087
uniprot
proteins
pubmed
20357911
uniprot
proteins
pubmed
20452352
uniprot
proteins
pubmed
21791603
uniprot
proteins
pubmed
21994467
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
33909987
uniprot
proteins
sequence_length
261
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16914734, ECO:0000269|PubMed:18006823, ECO:0000269|PubMed:19483087}. Nucleus speckle {ECO:0000269|PubMed:14701804}. Cytoplasm {ECO:0000269|PubMed:15781263, ECO:0000269|PubMed:18006823}.
uniprot
proteins