MBP
entrez
4155
canonical
uniprot
P02686
canonical
ensembl
ENSG00000197971
resolver
ensp
ENSP00000348273
resolver
ensp
ENSP00000352667
resolver
ensp
ENSP00000372025
resolver
ensp
ENSP00000380958
resolver
ensp
ENSP00000380963
resolver
ensp
ENSP00000380964
resolver
ensp
ENSP00000463780
resolver
genesymbol
MBP
resolver
hgnc
HGNC:6925
resolver
uniprot
A4FU54
resolver
uniprot
A6NI84
resolver
uniprot
A8MY86
resolver
uniprot
A8MYL4
resolver
uniprot
B3KY66
resolver
uniprot
B7ZKS2
resolver
uniprot
B7ZKS4
resolver
uniprot
Q15337
resolver
uniprot
Q15338
resolver
uniprot
Q15339
resolver
uniprot
Q15340
resolver
uniprot
Q59GX3
resolver
uniprot
Q65ZS4
resolver
uniprot
Q6AI64
resolver
uniprot
Q6FH37
resolver
uniprot
Q6FI04
resolver
uniprot
Q6PK23
resolver
uniprot_entry
MBP_HUMAN
resolver
uniprot_sec
A4FU54
resolver
uniprot_sec
A6NI84
resolver
uniprot_sec
A8MY86
resolver
uniprot_sec
A8MYL4
resolver
uniprot_sec
B3KY66
resolver
uniprot_sec
B7ZKS2
resolver
uniprot_sec
B7ZKS4
resolver
uniprot_sec
Q15337
resolver
uniprot_sec
Q15338
resolver
uniprot_sec
Q15339
resolver
uniprot_sec
Q15340
resolver
uniprot_sec
Q59GX3
resolver
uniprot_sec
Q65ZS4
resolver
uniprot_sec
Q6AI64
resolver
uniprot_sec
Q6FH37
resolver
uniprot_sec
Q6FI04
resolver
uniprot_sec
Q6PK23
resolver
amino_acid_sequence
MGNHAGKRELNAEKASTNSETNRGESEKKRNLGELSRTTSEDNEVFGEADANQNNGTSSQDTAVTDSKRTADPKNAWQDAHPADPGSRPHLIRLFSRDAPGREDNTFKDRPSESDELQTIQEDSAATSESLDVMASQKRPSQRHGSKYLATASTMDHARHGFLPRHRDTGILDSIGRFFGGDRGAPKRGSGKDSHHPARTAHYGSLPQKSHGRTQDENPVVHFFKNIVTPRTPPPSQGKGRGLSLSRFSWGAEGQRPGFGYGGRASDYKSAHKGFKGVDAQGTLSKIFKLGGRDSRSGSPMARR
uniprot
proteins
disease_involvement
DISEASE: Note=The reduction in the surface charge of citrullinated and/or methylated MBP could result in a weakened attachment to the myelin membrane. This mechanism could be operative in demyelinating diseases such as chronical multiple sclerosis (MS), and fulminating MS (Marburg disease).
uniprot
proteins
function
FUNCTION: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. {ECO:0000269|PubMed:8544862}.
uniprot
proteins
mass_dalton
33117
uniprot
proteins
post_translational_modification
PTM: Several charge isomers of MBP; C1 (the most cationic, least modified, and most abundant form), C2, C3, C4, C5, C6, C7, C8-A and C8-B (the least cationic form); are produced as a result of optional PTM, such as phosphorylation, deamidation of glutamine or asparagine, arginine citrullination and methylation. C8-A and C8-B contain each two mass isoforms termed C8-A(H), C8-A(L), C8-B(H) and C8-B(L), (H) standing for higher and (L) for lower molecular weight. C3, C4 and C5 are phosphorylated. The ratio of methylated arginine residues decreases during aging, making the protein more cationic. {ECO:0000269|PubMed:23828821, ECO:0000269|PubMed:2466844, ECO:0000269|PubMed:5128665}.; PTM: The N-terminal alanine is acetylated (isoform 3, isoform 4, isoform 5 and isoform 6).; PTM: Arg-241 was found to be 6% monomethylated and 60% symmetrically dimethylated.; PTM: Proteolytically cleaved in B cell lysosomes by cathepsin CTSG which degrades the major immunogenic MBP epitope and prevents the activation of MBP-specific autoreactive T cells. {ECO:0000269|PubMed:15100291}.; PTM: Phosphorylated by TAOK2, VRK2, MAPK11, MAPK12, MAPK14 and MINK1.
uniprot
proteins
protein_family
Myelin basic protein family
uniprot
proteins
pubmed
10660600
uniprot
proteins
pubmed
10880969
uniprot
proteins
pubmed
11080454
uniprot
proteins
pubmed
11163233
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15100291
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16079912
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
16337592
uniprot
proteins
pubmed
16704422
uniprot
proteins
pubmed
1689270
uniprot
proteins
pubmed
17158878
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
22609403
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23828821
uniprot
proteins
pubmed
2425357
uniprot
proteins
pubmed
2426402
uniprot
proteins
pubmed
2427738
uniprot
proteins
pubmed
2442403
uniprot
proteins
pubmed
2466844
uniprot
proteins
pubmed
2472816
uniprot
proteins
pubmed
4099924
uniprot
proteins
pubmed
4108501
uniprot
proteins
pubmed
5128665
uniprot
proteins
pubmed
6201481
uniprot
proteins
pubmed
7504278
uniprot
proteins
pubmed
7544282
uniprot
proteins
pubmed
7574672
uniprot
proteins
pubmed
7685161
uniprot
proteins
pubmed
8544862
uniprot
proteins
pubmed
9020143
uniprot
proteins
pubmed
9430721
uniprot
proteins
sequence_length
304
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of myelin.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus {ECO:0000269|PubMed:22609403}. Note=Targeted to nucleus in oligodendrocytes.
uniprot
proteins