Gabra3
entrez
24947
canonical
uniprot
P20236
canonical
ensembl
ENSRNOG00000056558
resolver
ensp
ENSRNOP00000070043
resolver
genesymbol
Gabra3
resolver
genesymbol_syn
Gabra-3
resolver
uniprot
F1LNZ5
resolver
uniprot_entry
GBRA3_RAT
resolver
uniprot_sec
F1LNZ5
resolver
amino_acid_sequence
MITTQMWHFYVTRVGLLLLISILPGTTGQGESRRQEPGDFVKQDIGGLSPKHAPDIPDDSTDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTKAEVIYSWTLGKNKSVEVAQDGSRLNQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRSWAWEGKKVPEALEMKKKTPAAPTKKTSTTFNIVGTTYPINLAKDTEFSTISKAAAAPSASSTPTVIASPKTTYVQDSPAETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVNRESAIKGMIRKQ
uniprot
proteins
function
FUNCTION: Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:2153588). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). {ECO:0000250|UniProtKB:P14867, ECO:0000250|UniProtKB:P34903, ECO:0000269|PubMed:2153588}.
uniprot
proteins
mass_dalton
55430
uniprot
proteins
protein_family
GABRA3 sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
17003036
uniprot
proteins
pubmed
1966765
uniprot
proteins
pubmed
2153588
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
24090084
uniprot
proteins
sequence_length
493
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:P14867}; Multi-pass membrane protein. Cell membrane {ECO:0000250|UniProtKB:P14867}; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 277..298; /note="Helical"; /evidence="ECO:0000305"; TRANSMEM 304..325; /note="Helical"; /evidence="ECO:0000305"; TRANSMEM 338..359; /note="Helical"; /evidence="ECO:0000305"; TRANSMEM 459..480; /note="Helical"; /evidence="ECO:0000305
uniprot
proteins