TMEM150B
entrez
284417
canonical
uniprot
A6NC51
canonical
ensembl
ENSG00000180061
resolver
ensp
ENSP00000320757
resolver
ensp
ENSP00000784327
resolver
enst
ENST00000326652
resolver
genesymbol
TMEM150B
resolver
genesymbol_syn
TMEM224
resolver
hgnc
HGNC:34415
resolver
uniprot
B7ZW71
resolver
uniprot_entry
T150B_HUMAN
resolver
uniprot_sec
B7ZW71
resolver
amino_acid_sequence
MWGYLSLMPVFLAVWAISGVWIVFAIAVTNRTVDLSKGFPYISICGSFPPQSCIFSQVLNMGAALAAWICIVRYHQLRDWGVRRWPNQLILWTGLLCALGTSVVGNFQEKNQRPTHLAGAFLAFILGNVYFWLQLLLWRLKRLPQPGAAWIGPLRLGLCSVCTILIVAMIVLHACSLRSVSAACEWVVAMLLFALFGLLAVDFSALESCTLCVQPWPSLSPPPASPISLPVQL
uniprot
proteins
function
FUNCTION: Modulator of macroautophagy that causes accumulation of autophagosomes under basal conditions and enhances autophagic flux (PubMed:25929859). Represses cell death and promotes long-term clonogenic survival of cells grown in the absence of glucose in a macroautophagy-independent manner (PubMed:25929859). May have some role in extracellular matrix engulfment or growth factor receptor recycling, both of which can modulate cell survival (PubMed:25929859). {ECO:0000269|PubMed:25929859}.
uniprot
proteins
mass_dalton
25701
uniprot
proteins
protein_family
DRAM/TMEM150 family
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
25608530
uniprot
proteins
pubmed
25929859
uniprot
proteins
sequence_length
233
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25608530, ECO:0000269|PubMed:25929859}; Multi-pass membrane protein {ECO:0000269|PubMed:25608530}. Endosome membrane {ECO:0000269|PubMed:25929859}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:25929859}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes mainly at the plasma membrane where it concentrates at actin-rich focal adhesions (PubMed:25608530, PubMed:25929859). {ECO:0000269|PubMed:25608530, ECO:0000269|PubMed:25929859}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 52..72; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 85..105; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 117..137; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 156..176; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 186..206; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins