Pspc1
entrez
305910
canonical
uniprot
Q4KLH4
canonical
ensembl
ENSRNOG00000020782
resolver
ensembl
ENSRNOG00055012311
resolver
ensembl
ENSRNOG00060017855
resolver
ensembl
ENSRNOG00065031815
resolver
ensp
ENSRNOP00000028219
resolver
ensp
ENSRNOP00055016933
resolver
ensp
ENSRNOP00060024815
resolver
ensp
ENSRNOP00065045088
resolver
enst
ENSRNOT00000028219
resolver
enst
ENSRNOT00055020961
resolver
enst
ENSRNOT00060030665
resolver
enst
ENSRNOT00065054823
resolver
genesymbol
Pspc1
resolver
uniprot_entry
PSPC1_RAT
resolver
amino_acid_sequence
MMLRGNLKQVRIEKNPARLRALESAAGESEPVAAAAMALTLAGEQPPPPAPSEEHPDEEMGFTIDIKSFLKPGEKTYTQRCRLFVGNLPTDITEEDFKRLFERYGEPSEVFINRDRGFGFIRLESRTLAEIAKAELDGTILKSRPLRIRFATHGAALTVKNLSPVVSNELLEQAFSQFGPVEKAVVVVDDRGRATGKGFVEFAAKPPARKALERCGDGAFLLTTTPRPVIVEPMEQFDDEDGLPEKLMQKTQQYHKEREQPPRFAQPGTFEFEYASRWKALDEMEKQQREQVDRNIREAKEKLEAEMEAARHEHQLMLMRQDLMRRQEELRRLEELRNQELQKRKQIQLRHEEEHRRREEEMIRHREQEELRRQQEGFKPNYMENREQEMRMGDMGPRGAINMGDAFSPAPAGTQGPPPMMGMNMNNRGTIPGPPMGPGPAMGPEGAANMGTPMIPDNGAVHNDRFPQGPPSQMGSPMGNRTGSETPQAPMSAVGPVSGGPGGFGRGSQGGNFEGPNKRRRY
uniprot
proteins
function
FUNCTION: RNA-binding protein required for the formation of nuclear paraspeckles (By similarity). Binds to poly(A), poly(G) and poly(U) RNA homopolymers (By similarity). Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (By similarity). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (By similarity). {ECO:0000250|UniProtKB:Q8R326, ECO:0000250|UniProtKB:Q8WXF1}.
uniprot
proteins
mass_dalton
58760
uniprot
proteins
protein_family
PSPC family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
522
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q8WXF1}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q8WXF1}. Nucleus matrix {ECO:0000250|UniProtKB:Q8R326}. Cytoplasm {ECO:0000250|UniProtKB:Q8R326}. Note=In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. Colocalizes with NONO and SFPQ in paraspeckles and perinucleolar caps in an RNA-dependent manner. May cycle between paraspeckles and nucleolus. In telophase, when daughter nuclei form, localizes to perinucleolar caps. {ECO:0000250|UniProtKB:Q8WXF1}.
uniprot
proteins