PDK2
entrez
5164
canonical
uniprot
Q15119
canonical
ensembl
ENSG00000005882
resolver
ensp
ENSP00000007708
resolver
ensp
ENSP00000420927
resolver
ensp
ENSP00000481915
resolver
genesymbol
PDK2
resolver
genesymbol_syn
PDHK2
resolver
hgnc
HGNC:8810
resolver
uniprot
A8K3A7
resolver
uniprot
B3KNW0
resolver
uniprot
Q6P515
resolver
uniprot
Q9BS05
resolver
uniprot_entry
PDK2_HUMAN
resolver
uniprot_sec
A8K3A7
resolver
uniprot_sec
B3KNW0
resolver
uniprot_sec
Q6P515
resolver
uniprot_sec
Q9BS05
resolver
activity_regulation
ACTIVITY REGULATION: Activity is enhanced by binding to the pyruvate dehydrogenase subunit DLAT. Inhibited by ADP and pyruvate; these compounds interfere with DLAT binding and thereby inhibit kinase activity. Inhibited by dichloroacetate. Inhibited by AZD7545; this compound interferes with DLAT binding and thereby inhibits kinase activity. {ECO:0000269|PubMed:15491150, ECO:0000269|PubMed:16517984, ECO:0000269|PubMed:19833728}.
uniprot
proteins
amino_acid_sequence
MRWVWALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGSTNPAHPKHIGSIDPNCNVSEVVKDAYDMAKLLCDKYYMASPDLEIQEINAANSKQPIHMVYVPSHLYHMLFELFKNAMRATVESHESSLILPPIKVMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS
uniprot
proteins
ec_number
2.7.11.2
uniprot
proteins
function
FUNCTION: Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis. {ECO:0000269|PubMed:17222789, ECO:0000269|PubMed:19833728, ECO:0000269|PubMed:21283817, ECO:0000269|PubMed:22123926, ECO:0000269|PubMed:7499431, ECO:0000269|PubMed:9787110}.
uniprot
proteins
mass_dalton
46154
uniprot
proteins
protein_family
PDK/BCKDK protein kinase family
uniprot
proteins
pubmed
12816949
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15491150
uniprot
proteins
pubmed
16401071
uniprot
proteins
pubmed
16517984
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17222789
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17669420
uniprot
proteins
pubmed
19833728
uniprot
proteins
pubmed
21283817
uniprot
proteins
pubmed
22123926
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
7499431
uniprot
proteins
pubmed
9787110
uniprot
proteins
sequence_length
407
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix.
uniprot
proteins