Tead4
entrez
21679
canonical
uniprot
Q62296
canonical
ensembl
ENSMUSG00000030353
resolver
ensp
ENSMUSP00000006311
resolver
ensp
ENSMUSP00000107784
resolver
genesymbol
Tead4
resolver
genesymbol_syn
Tcf13r1
resolver
genesymbol_syn
Tef3
resolver
genesymbol_syn
Tefr1
resolver
uniprot
A2BDD5
resolver
uniprot
P70282
resolver
uniprot
Q61174
resolver
uniprot
Q61175
resolver
uniprot
Q62298
resolver
uniprot_entry
TEAD4_MOUSE
resolver
uniprot_sec
A2BDD5
resolver
uniprot_sec
P70282
resolver
uniprot_sec
Q61174
resolver
uniprot_sec
Q61175
resolver
uniprot_sec
Q62298
resolver
amino_acid_sequence
MTSNEWSSPDSPEGSSISGGSQALDKPIDNDAEGVWSPEIERSFQEALAIYPPCGRRKIILTEEGKMYGRNELIARHIKLRTGKTRTRKQVSSHIQVLARRKAREIQAKLKDQAAKNKALQSMAAMSSAQIVSATAFHSKMALARGPGYPAISGFWQGALPGQPGTSHDVKPFSQNTYPVQPPLPLPGFESPAGPTPSPSAPLAPPWQGRSIASSKLWMLEFSAFLERQQDPDTYNKHLFVHISQSSPSYSDPYLETVDIRQIYDKFPEKKGGLKELFERGPSNAFFLVKFWADLNTNIDDEGSAFYGVSSQYESPENMIITCSTKVCSFGKQVVEKVETEYARYENGHYLYRIHRSPLCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTNRDTQETLLCIAYVFEVSASEHGAQHHIYRLVKE
uniprot
proteins
function
FUNCTION: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif (By similarity). Might play a role in the embryonic development of skeletal muscle. {ECO:0000250}.
uniprot
proteins
mass_dalton
48028
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20123908
uniprot
proteins
pubmed
8631987
uniprot
proteins
pubmed
8662936
uniprot
proteins
pubmed
8702974
uniprot
proteins
pubmed
8920920
uniprot
proteins
sequence_length
427
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins