Ctdspl2
entrez
329506
canonical
uniprot
Q8BG15
canonical
ensembl
ENSMUSG00000033411
resolver
ensp
ENSMUSP00000047543
resolver
ensp
ENSMUSP00000106207
resolver
ensp
ENSMUSP00000351924
resolver
genesymbol
Ctdspl2
resolver
genesymbol_syn
D2Ertd485e
resolver
genesymbol_syn
Scp4
resolver
uniprot
A2ARL6
resolver
uniprot
Q3TF86
resolver
uniprot
Q3TQW7
resolver
uniprot
Q3TV36
resolver
uniprot
Q7TPZ9
resolver
uniprot
Q8BPR3
resolver
uniprot
Q8C9S0
resolver
uniprot
Q8CEG6
resolver
uniprot_entry
CTSL2_MOUSE
resolver
uniprot_sec
A2ARL6
resolver
uniprot_sec
Q3TF86
resolver
uniprot_sec
Q3TQW7
resolver
uniprot_sec
Q3TV36
resolver
uniprot_sec
Q7TPZ9
resolver
uniprot_sec
Q8BPR3
resolver
uniprot_sec
Q8C9S0
resolver
uniprot_sec
Q8CEG6
resolver
amino_acid_sequence
MKLRTRKASQQSSPIQTQRTARAKRKYSEVDDSLPSGGEKPSKNETGLLSSIKKFIKGSTPKEERENPSKRSRIERDIDNNLITSTPRTGEKPDKQLSRVRRKSPVNGEAGSYEMTNQHIKQNGKLEDNPCSGSPPRTTLLGTIFSPVFNFFSPANKNGTSGSDSPGQAVEAEEIVKQLDMEQVDEITTSTTSANGAAYSNQAVQVRPSLNNGLEEAEETVTRDIPPLTAPVTPESGYSSAHAEATYEEDWEVFDPYYFIKHVPPLTEEQLNRKPALPLKTRSTPEFSLVLDLDETLVHCSLNELEDAALTFPVLFQDVIYQVYVRLRPFFREFLERMSQMYEIILFTASKKVYADKLLNILDPKKQLVRHRLFREHCVCVQGNYIKDLNILGRDLSKTIIIDNSPQAFAYQLSNGIPIESWFMDKNDNELLKLIPFLEKLVELNEDVRPHIRDRFRLHDLLPPD
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Serine/threonine phosphatase that promotes gluconeogenesis by dephosphorylating FOXO1 and FOXO3A within the nucleus, promoting their nuclear retention and enhancing their transcriptional activity on PCK1 and G6PC1, key enzymes in hepatic gluconeogenesis (PubMed:28851713). Essential for proper embryonic skeletal development by regulating chondrocyte survival through dephosphorylation of FOXO3 (PubMed:38886174). By maintaining FOXO3 in its active, dephosphorylated form, inhibits excessive apoptosis of chondrocytes, which is essential for normal endochondral ossification and cartilage formation (PubMed:38886174). {ECO:0000269|PubMed:28851713, ECO:0000269|PubMed:38886174}.
uniprot
proteins
mass_dalton
52813
uniprot
proteins
mutagenesis
MUTAGEN 294; /note="D->N: Loss of catalytic activity."; /evidence="ECO:0000269|PubMed:28851713
uniprot
proteins
protein_family
CTDSPL2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28851713
uniprot
proteins
pubmed
38886174
uniprot
proteins
sequence_length
465
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28851713}.
uniprot
proteins