Gramd2a
entrez
546134
canonical
uniprot
Q3V3G7
canonical
ensembl
ENSMUSG00000074259
resolver
ensp
ENSMUSP00000096258
resolver
ensp
ENSMUSP00000116879
resolver
genesymbol
Gramd2a
resolver
genesymbol_syn
Gramd2
resolver
uniprot
B2RSP5
resolver
uniprot
Q3V3E4
resolver
uniprot_entry
GRM2A_MOUSE
resolver
uniprot_sec
B2RSP5
resolver
uniprot_sec
Q3V3E4
resolver
amino_acid_sequence
MQMKMMFFCLSDWQSNQQMHGKMAPLKSHVPCTEKPGKVQEPPDDGSLHWSEGSKGEDIKKYSREGTLRSKYNQQYHKLFKDIPLEEVVLKVCSCALQRDLLLHGRLYISPNWLCFHASLFGKDIKVVIPVVSVQLIKKHKMARLLPNGLAITTNTSQKYVFVSLLSRDSVYDMLRRVCTHLQPSSKKSLSIRKFPEEAECESPEVLIPEMKWRKACSAPASLSLPDSISCISQIPTDSTDSCFPSRKPPGSEAVCEKDALEEEPSTDQELRLWDSRLLKVIFVMICFLVLSSSYLAFRISRLEQQLCSLSWGSPLPRDR
uniprot
proteins
function
FUNCTION: Participates in the organization ofendoplasmic reticulum-plasma membrane contact sites (EPCS) with pleiotropic functions including STIM1 recruitment and calcium homeostasis. Constitutive tether that co-localize with ESYT2/3 tethers at endoplasmic reticulum-plasma membrane contact sites in a phosphatidylinositol lipid-dependent manner. Pre-marks the subset of phosphtidylinositol 4,5-biphosphate (PI(4,5)P2)-enriched EPCS destined for the store operated calcium entry pathway (SOCE). {ECO:0000250|UniProtKB:Q8IUY3}.
uniprot
proteins
mass_dalton
36441
uniprot
proteins
post_translational_modification
PTM: Phosphorylated.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
320
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8IUY3}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q8IUY3}. Cell membrane {ECO:0000250|UniProtKB:Q8IUY3}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8IUY3}. Note=Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS). Anchored at the ER, PM binding is mediated via GRAM domain and phosphatidylinositol lipid interaction. Localizes to distinct EPCS than GRAMD1A. {ECO:0000250|UniProtKB:Q8IUY3}.
uniprot
proteins
transmembrane_region
TRANSMEM 278..298; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins