Map3k12
entrez
26404
canonical
uniprot
Q60700
canonical
ensembl
ENSMUSG00000023050
resolver
ensp
ENSMUSP00000023812
resolver
ensp
ENSMUSP00000127629
resolver
ensp
ENSMUSP00000133209
resolver
ensp
ENSMUSP00000179117
resolver
enst
ENSMUST00000023812
resolver
enst
ENSMUST00000169377
resolver
enst
ENSMUST00000171565
resolver
genesymbol
Map3k12
resolver
genesymbol_syn
Zpk
resolver
uniprot
P70286
resolver
uniprot
Q3TLL7
resolver
uniprot
Q8C4N7
resolver
uniprot
Q8CBX3
resolver
uniprot
Q8CDL6
resolver
uniprot_entry
M3K12_MOUSE
resolver
uniprot_sec
P70286
resolver
uniprot_sec
Q3TLL7
resolver
uniprot_sec
Q8C4N7
resolver
uniprot_sec
Q8CBX3
resolver
uniprot_sec
Q8CDL6
resolver
amino_acid_sequence
MACLHETRTPSPSFGGFVSTLSEASMRKLDPDTSDCTPEKDLTPTQCVLRDVVPLGGQGGGGPSPSPGGEPPPEPFANSVLQLHEQDTGGPGGATGSPESRASRVRADEVRLQCQSGSGFLEGLFGCLRPVWTMIGKAYSTEHKQQQEDLWEVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLRKLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHKIIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSFRQILLHLDIASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREELRHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKSHPSRGLLHGNTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGVGLPGCPKGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRAALPPHEPGGLGSPGGLGVGPSAWDACPPALRGLHHDLLLRKMSSSSPDLLSAALGARGRGATGGARDPGSPPPPQGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGVGLLGTGREGTAGRGGNRAGSQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELPPSQRWPQGPNMRQSLSTFSSENPSDVEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDLPTSEVVPEREASSLPMQHQDGQGPNPEDSDCDSTELDNSNSIDALRPPASLPP
uniprot
proteins
ec_number
2.7.11.25
uniprot
proteins
function
FUNCTION: Protein kinase which is part of a non-canonical MAPK signaling pathway (PubMed:28111074, PubMed:7983011, PubMed:8663324). Activated by APOE, enhances the AP-1-mediated transcription of APP, via a MAP kinase signal transduction pathway composed of MAP2K7 and MAPK1/ERK2 and MAPK3/ERK1 (PubMed:28111074). May be an activator of the JNK/SAPK pathway. {ECO:0000269|PubMed:28111074, ECO:0000269|PubMed:7983011, ECO:0000269|PubMed:8663324}.
uniprot
proteins
mass_dalton
96084
uniprot
proteins
mutagenesis
MUTAGEN 185; /note="K->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:8663324"; MUTAGEN 192; /note="E->A: No effect on kinase activity."; /evidence="ECO:0000269|PubMed:8663324
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated on Ser/Thr. Phosphorylated in cytosol under basal conditions and dephosphorylated when membrane-associated. {ECO:0000269|PubMed:7983011, ECO:0000269|PubMed:8663324}.; PTM: The activity of MAP3K12 can be regulated through its proteasomal degradation. APOE, through a receptor-mediated mechanism, activates MAP3K12 by preventing its proteasomal degradation. {ECO:0000250|UniProtKB:Q12852}.
uniprot
proteins
protein_family
MAP kinase kinase kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28111074
uniprot
proteins
pubmed
7983011
uniprot
proteins
pubmed
8663324
uniprot
proteins
pubmed
8769565
uniprot
proteins
sequence_length
888
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cell membrane {ECO:0000269|PubMed:8663324}. Note=Behaves essentially as an integral membrane protein. {ECO:0000269|PubMed:8663324}.
uniprot
proteins