Cd44
entrez
25406
canonical
uniprot
P26051
canonical
ensembl
ENSRNOG00000006094
resolver
ensp
ENSRNOP00000008760
resolver
ensp
ENSRNOP00000009000
resolver
ensp
ENSRNOP00000080825
resolver
ensp
ENSRNOP00000090715
resolver
enst
ENSRNOT00000008760
resolver
enst
ENSRNOT00000111131
resolver
enst
ENSRNOT00000111172
resolver
genesymbol
Cd44
resolver
genesymbol_syn
CD44
resolver
uniprot
A0A8I5ZRQ4
resolver
uniprot
A0A8I6GJ35
resolver
uniprot
A6HNP7
resolver
uniprot
D3ZGF1
resolver
uniprot
D4A7E6
resolver
uniprot
O08779
resolver
uniprot
O70509
resolver
uniprot
Q99021
resolver
uniprot_entry
A0A8I5ZRQ4_RAT
resolver
uniprot_entry
A0A8I6GJ35_RAT
resolver
uniprot_entry
CD44_RAT
resolver
uniprot_entry
D3ZGF1_RAT
resolver
uniprot_entry
O08779_RAT
resolver
uniprot_entry
O70509_RAT
resolver
uniprot_sec
A6HNP7
resolver
uniprot_sec
D4A7E6
resolver
uniprot_sec
Q99021
resolver
amino_acid_sequence
MDKVWWHTAWGLLCLLQLSLAQQQIDLNITCRYAGVFHVEKNGRYSISRTEAADLCEAFNTTLPTMAQMELALRKGFETCRYGFIEGHVVIPRIHPNAICAANNTGVYILLASNTSHYDTYCFNASAPLEEDCTSVTDLPNSFDGPVTITIVNRDGTRYSKKGEYRTHQEDIDASNIIDEDVSSGSTIEKSTPEGYILHTDLPTSQPTGDRDDAFFIGSTLATIATTPWVSAHTKQNQERTQWNPIHSNPEVLLQTTTRMTDIDRNSTSAHGENWTQEPQPPFNNHEYQDEEETPHATSTTWADPNSTTEEAATQKEKWFENEWQGKNPPTPSEDSHVTEGTTASAHNNHPSQRMTTQSQEDVSWTDFFDPISHPMGQGHQTESKGHSSGNQDSGVTTTSGPARRPQIPEWLIILASLLALALILAVCIAVNSRRRCGQKKKLVINSGNGTVEDRKPSELNGEASKSQEMVHLVNKEPTETPDQFMTADETRNLQSVDMKIGV
uniprot
proteins
function
FUNCTION: Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment. Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection. Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases. Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion. Upon interaction with LGALS9 ligand, activates downstream signaling components including LCK, ERK and MAPK to promotes NK cell activation. {ECO:0000250|UniProtKB:P16070}.
uniprot
proteins
mass_dalton
55946
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:P16070}.; PTM: O-glycosylated; contains chondroitin sulfate glycans which can be more or less sulfated. {ECO:0000250|UniProtKB:P16070}.; PTM: Phosphorylated; activation of PKC results in the dephosphorylation of Ser-467 (constitutive phosphorylation site), and the phosphorylation of Ser-433. {ECO:0000250}.
uniprot
proteins
pubmed
1707342
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9692903
uniprot
proteins
sequence_length
503
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P15379}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P15379}. Cell projection, microvillus {ECO:0000250|UniProtKB:P15379}. Secreted {ECO:0000250|UniProtKB:P16070}. Note=Colocalizes with actin in membrane protrusions at wounding edges. Co-localizes with RDX, EZR and MSN in microvilli. {ECO:0000250|UniProtKB:P15379}.
uniprot
proteins
transmembrane_region
TRANSMEM 411..431; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins