Stx1a
entrez
116470
canonical
uniprot
P32851
canonical
ensembl
ENSRNOG00000029165
resolver
ensembl
ENSRNOG00055000331
resolver
ensembl
ENSRNOG00060011988
resolver
ensembl
ENSRNOG00065001365
resolver
ensp
ENSRNOP00000040699
resolver
ensp
ENSRNOP00055000447
resolver
ensp
ENSRNOP00060015996
resolver
ensp
ENSRNOP00065001263
resolver
enst
ENSRNOT00000049601
resolver
enst
ENSRNOT00055000584
resolver
enst
ENSRNOT00060020334
resolver
enst
ENSRNOT00065001813
resolver
genesymbol
Stx1a
resolver
genesymbol_syn
Sap
resolver
uniprot_entry
STX1A_RAT
resolver
amino_acid_sequence
MKDRTQELRTAKDSDDDDDVTVTVDRDRFMDEFFEQVEEIRGFIDKIAENVEEVKRKHSAILASPNPDEKTKEELEELMSDIKKTANKVRSKLKSIEQSIEQEEGLNRSSADLRIRKTQHSTLSRKFVEVMSEYNATQSDYRERCKGRIQRQLEITGRTTTSEELEDMLESGNPAIFASGIIMDSSISKQALSEIETRHSEIIKLENSIRELHDMFMDMAMLVESQGEMIDRIEYNVEHAVDYVERAVSDTKKAVKYQSKARRKKIMIIICCVILGIIIASTIGGIFG
uniprot
proteins
function
FUNCTION: Plays an essential role in hormone and neurotransmitter calcium-dependent exocytosis and endocytosis (PubMed:17301173, PubMed:18167541, PubMed:20484665, PubMed:22411134, PubMed:28813412, PubMed:7901002). Part of the SNARE (Soluble NSF Attachment Receptor) complex composed of SNAP25, STX1A and VAMP2 which mediates the fusion of synaptic vesicles with the presynaptic plasma membrane (PubMed:14665625, PubMed:16888141, PubMed:19571812). STX1A and SNAP25 are localized on the plasma membrane while VAMP2 resides in synaptic vesicles. The pairing of the three SNAREs from the N-terminal SNARE motifs to the C-terminal anchors leads to the formation of the SNARE complex, which brings membranes into close proximity and results in final fusion (PubMed:14665625, PubMed:16888141, PubMed:19571812). Participates in the calcium-dependent regulation of acrosomal exocytosis in sperm (By similarity). Also plays an important role in the exocytosis of hormones such as insulin or glucagon-like peptide 1 (GLP-1) (By similarity). {ECO:0000250|UniProtKB:O35526, ECO:0000269|PubMed:14665625, ECO:0000269|PubMed:16888141, ECO:0000269|PubMed:17301173, ECO:0000269|PubMed:18167541, ECO:0000269|PubMed:19571812, ECO:0000269|PubMed:20484665, ECO:0000269|PubMed:22411134, ECO:0000269|PubMed:28813412, ECO:0000269|PubMed:7901002}.
uniprot
proteins
mass_dalton
33067
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CK2. Phosphorylation at Ser-188 by DAPK1 significantly decreases its interaction with STXBP1. {ECO:0000269|PubMed:12730201}.; PTM: (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type C (BoNT/C), which hydrolyzes the 253-Lys-|-Ala-254 bond (PubMed:7737992). Cleavage inhibits neurotransmitter release (PubMed:7901002). {ECO:0000269|PubMed:7737992, ECO:0000269|PubMed:7901002}.; PTM: Phosphorylated by CK2 (By similarity). Phosphorylation at Ser-188 by DAPK1 significantly decreases its interaction with STXBP1 (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q16623}.; PTM: Sumoylated, sumoylation is required for regulation of synaptic vesicle endocytosis. {ECO:0000250|UniProtKB:Q16623}.
uniprot
proteins
protein_family
Syntaxin family
uniprot
proteins
pubmed
10336434
uniprot
proteins
pubmed
10746715
uniprot
proteins
pubmed
10913252
uniprot
proteins
pubmed
11118447
uniprot
proteins
pubmed
11533035
uniprot
proteins
pubmed
11709063
uniprot
proteins
pubmed
11832227
uniprot
proteins
pubmed
12145319
uniprot
proteins
pubmed
12496247
uniprot
proteins
pubmed
12730201
uniprot
proteins
pubmed
1321498
uniprot
proteins
pubmed
1334074
uniprot
proteins
pubmed
14642278
uniprot
proteins
pubmed
14665625
uniprot
proteins
pubmed
1587842
uniprot
proteins
pubmed
16888141
uniprot
proteins
pubmed
17301173
uniprot
proteins
pubmed
18167541
uniprot
proteins
pubmed
18337752
uniprot
proteins
pubmed
19196426
uniprot
proteins
pubmed
19571812
uniprot
proteins
pubmed
20484665
uniprot
proteins
pubmed
21785414
uniprot
proteins
pubmed
22411134
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23341457
uniprot
proteins
pubmed
26280336
uniprot
proteins
pubmed
28813412
uniprot
proteins
pubmed
7690687
uniprot
proteins
pubmed
7737992
uniprot
proteins
pubmed
7901002
uniprot
proteins
pubmed
9507000
uniprot
proteins
pubmed
9753330
uniprot
proteins
pubmed
9759724
uniprot
proteins
sequence_length
288
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:O35526}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:O35526}. Cell membrane {ECO:0000269|PubMed:17301173, ECO:0000269|PubMed:18167541, ECO:0000269|PubMed:20484665, ECO:0000269|PubMed:22411134, ECO:0000269|PubMed:23341457}. Synapse, synaptosome {ECO:0000250|UniProtKB:O35526}. Note=Colocalizes with KCNB1 at the cell membrane (PubMed:17301173). Colocalizes with PLCL1 at the cell membrane (PubMed:22673903). {ECO:0000269|PubMed:17301173}.
uniprot
proteins
transmembrane_region
TRANSMEM 266..288; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins