Q9WVL2
uniprot
Q9WVL2
canonical
amino_acid_sequence
MAQWEMLQNLDSPFLDQLHQVYSQSFLPMDFRQHLASWIEDQNWREAALESDDAKANMLYFSILDQLNQWDHYSSDPKSLLLQHNLRKFSRDIQPFPNGPSQLAEMIFNLLLEEQRILIQAQRAQEVQPPPAPEAVVESQQLEIENRIQGLHVDIEFLVRSIRQLKDEQDVFSFRYTVFSLKKTSSSDPHQSQQAHVVQATANKVDRMRKEVLDISKGLVGRLTTLVDLLLPKLDEWKVQQQKSCIGAPPPVKSAAEQLEQWLTAGAKFLFHLRQLLKQLKEMSCLRYQGDMFAKGVDLRNAQVMELLQRLLQRSFVVETQPCMPQTLHRPLILKTGNKFTVRTRLLVRLQEGSESLKAEVSVDRNSDLPGFRKFNILTSNQKTLTPEKGQRQGLIWDFGFLTLVEQRAVGAGKGNNKGPLAVTEELHVISFVVEYTYQGLKMKLQTDTLPVVIISNMNQLSFAWASILWFNMLSPNPKNQQFFCQAPKAPWSLLGPVLSWQFSSYVARGLDSEQLGMLRTKLFGKSCKMEDALLSWVDFCKRESPPGKIPFWTWLDKILELVHDHLKDLWKDGRIMGFVSRNQERRLLKKMLSGTFLLRFSETSEGGITCSWVEHQDDHKVEIYSVQPYTKEVLQSLPLTEIIRHYQVLAEENIPENPLRFLYPRIPRDEAFGCYYQEKVNLEEQEEYLKHKLIVISNRQVDELQQPLELKQDSESLEVNAELLLAHDQELPLMMQTGLVLGTELKVDPILSTAPQVLLEPAPQVLLEPAPQVLLEPAPQVLLEPAPQVLLEPAPQVLLEPAPQVLLEPAPQVQLEPAPQVLLELAPQVLLEPAPQVLLELAPQVQLEPAHLLQQPSESDLPEDLQQISVEDLKKLSNPSTEYITTNENPMLAGESSGDETSIPYHSHFDADGLLGWTLDTF
uniprot
proteins
function
FUNCTION: Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In addition, also has a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs. Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively. {ECO:0000250|UniProtKB:P52630}.
uniprot
proteins
mass_dalton
105417
uniprot
proteins
post_translational_modification
PTM: Tyrosine phosphorylated in response to IFN-alpha. {ECO:0000250}.; PTM: 'Lys-48'-linked ubiquitination by DCST1 leads to STAT2 proteasomal degradation. {ECO:0000250|UniProtKB:P52630}.
uniprot
proteins
protein_family
Transcription factor STAT family
uniprot
proteins
pubmed
17332413
uniprot
proteins
pubmed
18234692
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8601453
uniprot
proteins
sequence_length
923
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P52630}. Nucleus {ECO:0000250|UniProtKB:P52630}. Note=Translocated into the nucleus upon activation by IFN-alpha/beta. {ECO:0000250|UniProtKB:P52630}.
uniprot
proteins