Igfbp5
entrez
25285
canonical
uniprot
P24594
canonical
ensembl
ENSRNOG00000017206
resolver
ensembl
ENSRNOG00055010024
resolver
ensembl
ENSRNOG00060007038
resolver
ensembl
ENSRNOG00065008601
resolver
ensp
ENSRNOP00000023530
resolver
ensp
ENSRNOP00055013621
resolver
ensp
ENSRNOP00060008678
resolver
ensp
ENSRNOP00065010142
resolver
enst
ENSRNOT00000023530
resolver
enst
ENSRNOT00055016923
resolver
enst
ENSRNOT00060011558
resolver
enst
ENSRNOT00065013665
resolver
genesymbol
Igfbp5
resolver
genesymbol_syn
Igfbp-5
resolver
uniprot_entry
IBP5_RAT
resolver
amino_acid_sequence
MVISVVLLLLAACAVPAQGLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYGEQTKIERDSREHEEPTTSEMAEETYSPKVFRPKHTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVIPAPEMRQESDQGPCRRHMEASLQEFKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHAFDSSNVE
uniprot
proteins
function
FUNCTION: Multifunctional protein that plays a critical role in regulating the availability of IGFs to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:23417767). Increases the cell proliferation of osteoblasts, intestinal smooth muscle cells and neuroblastoma cells (By similarity). Enhances adhesion and survival of epithelial cells but decreases adhesion of mesenchymal cells (By similarity). Once secreted, acts as a major mediator of mTORC1-dependent feedback inhibition of IGF1 signaling (By similarity). Also plays a role in the induction of extracellular matrix (ECM) production and deposition independently of its nuclear translocation and binding to IGFs. Acts itself as a growth factor that can act independently of IGFs to regulate bone formation. Acts as a ligand for the ROR1 receptor which triggers formation of ROR1/HER2 heterodimer to enhance CREB oncogenic signaling (By similarity). {ECO:0000250|UniProtKB:P24593, ECO:0000250|UniProtKB:Q07079, ECO:0000269|PubMed:23417767}.
uniprot
proteins
mass_dalton
30298
uniprot
proteins
pubmed
1709938
uniprot
proteins
pubmed
23417767
uniprot
proteins
pubmed
7679898
uniprot
proteins
sequence_length
271
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P24593}. Cytoplasm {ECO:0000250|UniProtKB:P24593}. Nucleus {ECO:0000250|UniProtKB:P24593}.
uniprot
proteins