Pex12
entrez
103737
canonical
uniprot
Q8VC48
canonical
ensembl
ENSMUSG00000018733
resolver
ensp
ENSMUSP00000018877
resolver
ensp
ENSMUSP00000103781
resolver
ensp
ENSMUSP00000135145
resolver
ensp
ENSMUSP00000135632
resolver
ensp
ENSMUSP00000183191
resolver
ensp
ENSMUSP00000183192
resolver
enst
ENSMUST00000018877
resolver
enst
ENSMUST00000108146
resolver
enst
ENSMUST00000175741
resolver
enst
ENSMUST00000176518
resolver
genesymbol
Pex12
resolver
uniprot
Q5SWQ8
resolver
uniprot_entry
PEX12_MOUSE
resolver
uniprot_entry
Q5SWQ8_MOUSE
resolver
amino_acid_sequence
MAEYGAHITTASVADDQPSIFEVVAQDSLMTAVRPALQHVVKVLAESNPAHYGFLWRWFDEIFTLLDFLLQQHYLSRTSASFSEHFYGLKRIVAGSSPHLQRPASAGLPKEHLWKSAMFLVLLPYLKVKLEKLASSLREEDEYSIHPPSSRWKRFYRAFLAAYPFVNMAWEGWFLTQQLRYILGKAEHHSPLLKLAGVRLARLTAQDMQAIKQRLVEASAMQEPVRSVGEKIKSALKKAVGGVALSLSTGLSVGVFFLQFLDWWYSSENQEAIKSLTALPTPPPPVHLDYNSDSPLLPKMKTVCPLCRKTRVNDTVLATSGYVFCYRCVFNYVRSHQACPITGYPTEVQHLIKLYSPEN
uniprot
proteins
function
FUNCTION: Component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling (By similarity). The retrotranslocation channel is composed of PEX2, PEX10 and PEX12; each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane (By similarity). PEX12 also regulates PEX5 recycling by activating the E3 ubiquitin-protein ligase activity of PEX10 (By similarity). When PEX5 recycling is compromised, PEX12 stimulates PEX10-mediated polyubiquitination of PEX5, leading to its subsequent degradation (By similarity). {ECO:0000250|UniProtKB:O00623, ECO:0000250|UniProtKB:Q04370}.
uniprot
proteins
mass_dalton
40633
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:O00623}.
uniprot
proteins
protein_family
Pex2/pex10/pex12 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
359
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000250|UniProtKB:O00623}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 20..47; /note="Helical; Name=TM1"; /evidence="ECO:0000250|UniProtKB:G2Q5N0"; TRANSMEM 52..76; /note="Helical; Name=TM2"; /evidence="ECO:0000250|UniProtKB:G2Q5N0"; TRANSMEM 110..139; /note="Helical; Name=TM3"; /evidence="ECO:0000250|UniProtKB:G2Q5N0"; TRANSMEM 145..183; /note="Helical; Name=TM4"; /evidence="ECO:0000250|UniProtKB:G2Q5N0"; TRANSMEM 250..277; /note="Helical; Name=TM5"; /evidence="ECO:0000250|UniProtKB:G2Q5N0
uniprot
proteins