Sst
entrez
24797
canonical
uniprot
P60042
canonical
ensembl
ENSRNOG00000001837
resolver
ensembl
ENSRNOG00055004598
resolver
ensembl
ENSRNOG00060013122
resolver
ensembl
ENSRNOG00065003504
resolver
ensp
ENSRNOP00000002519
resolver
ensp
ENSRNOP00055005443
resolver
ensp
ENSRNOP00060017754
resolver
ensp
ENSRNOP00065003541
resolver
enst
ENSRNOT00000002519
resolver
enst
ENSRNOT00055007282
resolver
enst
ENSRNOT00060022371
resolver
enst
ENSRNOT00065005000
resolver
genesymbol
Sst
resolver
genesymbol_syn
Smst
resolver
uniprot
P01167
resolver
uniprot_entry
SMS_RAT
resolver
uniprot_sec
P01167
resolver
amino_acid_sequence
MLSCRLQCALAALCIVLALGGVTGAPSDPRLRQFLQKSLAAATGKQELAKYFLAELLSEPNQTENDALEPEDLPQAAEQDEMRLELQRSANSNPAMAPRERKAGCKNFFWKTFTSC
uniprot
proteins
function
FUNCTION: [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin. {ECO:0000250|UniProtKB:P61278}.; FUNCTION: [Neuronostatin]: May enhance low-glucose-induced glucagon release by pancreatic alpha cells (PubMed:24735892). This effect may be mediated by binding to GPR107 and PKA activation (PubMed:26561648). May regulate cardiac contractile function (PubMed:22170057). May compromise cardiomyocyte viability (PubMed:22170057). In the central nervous system, may impair memory retention and may affect hippocampal excitability (PubMed:21978882). May also have anxiolytic and anorexigenic effects (PubMed:18753129, PubMed:21978882). May play a role in arterial pressure regulation (PubMed:18753129, PubMed:21978882). May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH (By similarity). Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH (By similarity). {ECO:0000250|UniProtKB:P61278, ECO:0000269|PubMed:18753129, ECO:0000269|PubMed:21978882, ECO:0000269|PubMed:22170057, ECO:0000269|PubMed:24735892, ECO:0000269|PubMed:26561648}.
uniprot
proteins
mass_dalton
12746
uniprot
proteins
post_translational_modification
PTM: C-terminal amidation of the neuronostatin peptide is required for its biological activity, including for the regulation of mean arterial pressure. {ECO:0000269|PubMed:21325646}.
uniprot
proteins
protein_family
Somatostatin family
uniprot
proteins
pubmed
18753129
uniprot
proteins
pubmed
20056135
uniprot
proteins
pubmed
21325646
uniprot
proteins
pubmed
21978882
uniprot
proteins
pubmed
22170057
uniprot
proteins
pubmed
24735892
uniprot
proteins
pubmed
26561648
uniprot
proteins
pubmed
2863939
uniprot
proteins
pubmed
2891188
uniprot
proteins
pubmed
6120163
uniprot
proteins
pubmed
6133871
uniprot
proteins
pubmed
6145156
uniprot
proteins
pubmed
6148343
uniprot
proteins
sequence_length
116
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:26561648}.
uniprot
proteins