NPSR1
entrez
387129
canonical
uniprot
Q6W5P4
canonical
ensembl
ENSG00000187258
resolver
ensp
ENSP00000352839
resolver
ensp
ENSP00000353788
resolver
ensp
ENSP00000370950
resolver
ensp
ENSP00000370953
resolver
ensp
ENSP00000433258
resolver
genesymbol
NPSR1
resolver
genesymbol_syn
GPR154
resolver
genesymbol_syn
GPRA
resolver
genesymbol_syn
PGR14
resolver
hgnc
HGNC:23631
resolver
uniprot
A2RTZ4
resolver
uniprot
Q2XP58
resolver
uniprot
Q56H76
resolver
uniprot
Q56H77
resolver
uniprot
Q56H78
resolver
uniprot
Q6JSL4
resolver
uniprot
Q6JSL5
resolver
uniprot
Q6JSL6
resolver
uniprot
Q6JSL7
resolver
uniprot
Q6JSL8
resolver
uniprot
Q6W5P3
resolver
uniprot
Q6ZMB8
resolver
uniprot_entry
NPSR1_HUMAN
resolver
uniprot_sec
A2RTZ4
resolver
uniprot_sec
Q2XP58
resolver
uniprot_sec
Q56H76
resolver
uniprot_sec
Q56H77
resolver
uniprot_sec
Q56H78
resolver
uniprot_sec
Q6JSL4
resolver
uniprot_sec
Q6JSL5
resolver
uniprot_sec
Q6JSL6
resolver
uniprot_sec
Q6JSL7
resolver
uniprot_sec
Q6JSL8
resolver
uniprot_sec
Q6W5P3
resolver
uniprot_sec
Q6ZMB8
resolver
amino_acid_sequence
MPANFTEGSFDSSGTGQTLDSSPVACTETVTFTEVVEGKEWGSFYYSFKTEQLITLWVLFVFTIVGNSVVLFSTWRRKKKSRMTFFVTQLAITDSFTGLVNILTDINWRFTGDFTAPDLVCRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQARVLIVIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLTIISIMYGIVIRTIWIKSKTYETVISNCSDGKLCSSYNRGLISKAKIKAIKYSIIIILAFICCWSPYFLFDILDNFNLLPDTQERFYASVIIQNLPALNSAINPLIYCVFSSSISFPCREQRSQDSRMTFRERTERHEMQILSKPEFI
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for neuropeptide S (NPS) (PubMed:15947423, PubMed:16720571, PubMed:16790440). Receptor activation by NPS initiates a G(q)/GNAQ-dependent phospholipase C-activating signaling pathway, resulting in Ca(2+) mobilization from intracellular stores and increased intracellular Ca(2+) levels (PubMed:15312648, PubMed:15947423, PubMed:16720571, PubMed:16790440, PubMed:25714705, PubMed:26865629). In addition to this pathway, NPS binding to its receptor activates cAMP/PKA signal transduction (PubMed:26865629). Finally, both pathways converge to activate ERK1/ERK2 phosphorylation and signaling cascade (PubMed:26865629). Inhibits cell growth in response to NPS binding (PubMed:15947423). {ECO:0000269|PubMed:15312648, ECO:0000269|PubMed:15947423, ECO:0000269|PubMed:16720571, ECO:0000269|PubMed:16790440, ECO:0000269|PubMed:25714705, ECO:0000269|PubMed:26865629}.
uniprot
proteins
mass_dalton
42687
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Vasopressin/oxytocin receptor subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15073379
uniprot
proteins
pubmed
15312648
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15947423
uniprot
proteins
pubmed
16720571
uniprot
proteins
pubmed
16790440
uniprot
proteins
pubmed
25714705
uniprot
proteins
pubmed
26865629
uniprot
proteins
pubmed
31619542
uniprot
proteins
sequence_length
371
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:15947423, ECO:0000269|PubMed:16790440}; Multi-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000269|PubMed:15947423}; Multi-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000269|PubMed:15947423}; Multi-pass membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:15947423}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:15947423}.; SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm {ECO:0000269|PubMed:15947423}.; SUBCELLULAR LOCATION: [Isoform 7]: Cytoplasm {ECO:0000269|PubMed:15947423}.; SUBCELLULAR LOCATION: [Isoform 9]: Cytoplasm {ECO:0000269|PubMed:15947423}.
uniprot
proteins
transmembrane_region
TRANSMEM 53..73; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 83..103; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 124..144; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 165..185; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 213..233; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 276..296; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 313..333; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins