MRS2
entrez
57380
canonical
uniprot
Q9HD23
canonical
ensembl
ENSG00000124532
resolver
ensp
ENSP00000274747
resolver
ensp
ENSP00000367604
resolver
ensp
ENSP00000367637
resolver
ensp
ENSP00000399585
resolver
ensp
ENSP00000543901
resolver
enst
ENST00000274747
resolver
genesymbol
MRS2
resolver
genesymbol_syn
HPT
resolver
genesymbol_syn
MRS2L
resolver
hgnc
HGNC:13785
resolver
uniprot
A0A0A0MQX2
resolver
uniprot
A8K4U3
resolver
uniprot
B3KNN2
resolver
uniprot
B4DQL2
resolver
uniprot
B4DSN2
resolver
uniprot
Q5T3Y1
resolver
uniprot
Q6NTG4
resolver
uniprot
Q96KF8
resolver
uniprot
Q9BVP1
resolver
uniprot_entry
A0A0A0MQX2_HUMAN
resolver
uniprot_entry
B4DSN2_HUMAN
resolver
uniprot_entry
MRS2_HUMAN
resolver
uniprot_sec
A8K4U3
resolver
uniprot_sec
B3KNN2
resolver
uniprot_sec
B4DQL2
resolver
uniprot_sec
Q5T3Y1
resolver
uniprot_sec
Q6NTG4
resolver
uniprot_sec
Q96KF8
resolver
uniprot_sec
Q9BVP1
resolver
activity_regulation
ACTIVITY REGULATION: May be regulated by calcium ions. {ECO:0000269|PubMed:39609651}.
uniprot
proteins
amino_acid_sequence
MECLRSLPCLLPRAMRLPRRTLCALALDVTSVGPPVAACGRRANLIGRSRAAQLCGPDRLRVAGEVHRFRTSDVSQATLASVAPVFTVTKFDKQGNVTSFERKKTELYQELGLQARDLRFQHVMSITVRNNRIIMRMEYLKAVITPECLLILDYRNLNLEQWLFRELPSQLSGEGQLVTYPLPFEFRAIEALLQYWINTLQGKLSILQPLILETLDALVDPKHSSVDRSKLHILLQNGKSLSELETDIKIFKESILEILDEEELLEELCVSKWSDPQVFEKSSAGIDHAEEMELLLENYYRLADDLSNAARELRVLIDDSQSIIFINLDSHRNVMMRLNLQLTMGTFSLSLFGLMGVAFGMNLESSLEEDHRIFWLITGIMFMGSGLIWRRLLSFLGRQLEAPLPPMMASLPKKTLLADRSMELKNSLRLDGLGSGRSILTNR
uniprot
proteins
function
FUNCTION: Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix and regulates magnesium metabolism (PubMed:11401429, PubMed:18384665, PubMed:37543649, PubMed:37938562, PubMed:39609651). Also permeable to calcium, sodium and potassium ions (PubMed:39609651). Required for normal expression of the mitochondrial respiratory complex I subunits (PubMed:18384665). May play a role in maintaining the inner mitochondrial membrane potential (PubMed:39609651). {ECO:0000269|PubMed:11401429, ECO:0000269|PubMed:18384665, ECO:0000269|PubMed:37543649, ECO:0000269|PubMed:37938562, ECO:0000269|PubMed:39609651}.
uniprot
proteins
mass_dalton
50318
uniprot
proteins
protein_family
CorA metal ion transporter (MIT) (TC 1.A.35) family
uniprot
proteins
pubmed
11401429
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18384665
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
37543649
uniprot
proteins
pubmed
37938562
uniprot
proteins
pubmed
39609651
uniprot
proteins
sequence_length
443
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:11401429, ECO:0000305|PubMed:18384665}; Multi-pass membrane protein {ECO:0000269|PubMed:37543649, ECO:0000269|PubMed:37938562, ECO:0000269|PubMed:39609651}.
uniprot
proteins
transmembrane_region
TRANSMEM 340..359; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:37543649, ECO:0000269|PubMed:37938562, ECO:0000269|PubMed:39609651, ECO:0007744|PDB:8IP3, ECO:0007744|PDB:8IP4, ECO:0007744|PDB:8IP5, ECO:0007744|PDB:8IP6, ECO:0007744|PDB:8TS1, ECO:0007744|PDB:8TS2, ECO:0007744|PDB:8TS3, ECO:0007744|PDB:8TUL, ECO:0007744|PDB:8TUP"; TRANSMEM 371..401; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:37543649, ECO:0000269|PubMed:37938562, ECO:0000269|PubMed:39609651, ECO:0007744|PDB:8IP3, ECO:0007744|PDB:8IP4, ECO:0007744|PDB:8IP5, ECO:0007744|PDB:8IP6, ECO:0007744|PDB:8TS1, ECO:0007744|PDB:8TS2, ECO:0007744|PDB:8TS3, ECO:0007744|PDB:8TUL, ECO:0007744|PDB:8TUP
uniprot
proteins