Htr2c
entrez
25187
canonical
uniprot
P08909
canonical
ensembl
ENSRNOG00000030877
resolver
ensembl
ENSRNOG00055024346
resolver
ensembl
ENSRNOG00060018315
resolver
ensembl
ENSRNOG00065009778
resolver
ensp
ENSRNOP00000060345
resolver
ensp
ENSRNOP00055034111
resolver
ensp
ENSRNOP00060025592
resolver
ensp
ENSRNOP00065011925
resolver
enst
ENSRNOT00000065293
resolver
enst
ENSRNOT00055041874
resolver
enst
ENSRNOT00060031522
resolver
enst
ENSRNOT00065015758
resolver
genesymbol
Htr2c
resolver
genesymbol_syn
5ht1c
resolver
genesymbol_syn
Htr1c
resolver
uniprot
Q62842
resolver
uniprot_entry
5HT2C_RAT
resolver
uniprot_entry
Q62842_RAT
resolver
amino_acid_sequence
MVNLGNAVRSLLMHLIGLLVWQFDISISPVAAIVTDTFNSSDGGRLFQFPDGVQNWPALSIVVIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDESKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYFLTIYVLRRQTLMLLRGHTEEELANMSLNFLNCCCKKNGGEEENAPNPNPDQKPRRKKKEKRPRGTMQAINNEKKASKVLGIVFFVFLIMWCPFFITNILSVLCGKACNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSKYLRCDYKPDKKPPVRQIPRVAATALSGRELNVNIYRHTNERVARKANDPEPGIEMQVENLELPVNPSNVVSERISSV
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:3399891). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). HTR2C is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively (By similarity). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (By similarity). Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelanocortin neurons and the release of CRH that then regulates the release of corticosterone (By similarity). Plays a role in the regulation of appetite and eating behavior, responses to anxiogenic stimuli and stress (By similarity). Plays a role in insulin sensitivity and glucose homeostasis (By similarity). {ECO:0000250|UniProtKB:P28335, ECO:0000250|UniProtKB:P34968, ECO:0000269|PubMed:3399891}.
uniprot
proteins
mass_dalton
51917
uniprot
proteins
mutagenesis
MUTAGEN 458; /note="S->A,D: Loss of interaction with MPDZ."; /evidence="ECO:0000269|PubMed:12682077"; MUTAGEN 459; /note="S->D: No effect on interaction with MPDZ."; /evidence="ECO:0000269|PubMed:12682077
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12682077
uniprot
proteins
pubmed
3399891
uniprot
proteins
sequence_length
460
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:3399891}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 57..81; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P28335"; TRANSMEM 88..112; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P28335"; TRANSMEM 130..152; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P28335"; TRANSMEM 169..190; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P28335"; TRANSMEM 215..237; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P28335"; TRANSMEM 314..338; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P28335"; TRANSMEM 350..372; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P28335
uniprot
proteins