Rab12
entrez
25530
canonical
uniprot
P35284
canonical
ensembl
ENSRNOG00000019295
resolver
ensp
ENSRNOP00000076702
resolver
genesymbol
Rab12
resolver
uniprot_entry
RAB12_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) including DENND3 which promote the exchange of bound GDP for free GTP (By similarity). Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs) (Probable). {ECO:0000250|UniProtKB:Q6IQ22, ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MLLPLLRRSCFPSSTPGGGGSGGGAERVEGARGPGARGRRPEREPYACMDPSAALHRRPAGGGLGAVSPALSGGQARRRKQPPRPADFKLQVIIIGSRGVGKTSLMERFTDDTFCEACKSTVGVDFKIKTVELRGKKIRLQIWDTAGQERFNSITSAYYRSAKGIILVYDITKKETFDDLPKWMKMIDKYASEDAELLLVGNKLDCETDREISRQQGEKFAQQITGMRFCEASAKDNFNVDEIFLKLVDDILKKMPLDVLRSELSNSILSLQPEPEIPPELPPPRPHVRCC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB12 may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy (By similarity). {ECO:0000250|UniProtKB:P35283, ECO:0000250|UniProtKB:P61026}.
uniprot
proteins
mass_dalton
32181
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Ser-153 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM and RAB GDP dissociation inhibitors GDI1 and GDI2. {ECO:0000250|UniProtKB:Q6IQ22}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
1313420
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15791598
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
291
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000250|UniProtKB:P35283}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Lysosome membrane {ECO:0000250|UniProtKB:P35283}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P51152}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:P35283}.
uniprot
proteins