PRDM1
entrez
639
canonical
uniprot
O75626
canonical
ensembl
ENSG00000057657
resolver
ensp
ENSP00000358085
resolver
ensp
ENSP00000358087
resolver
ensp
ENSP00000358092
resolver
ensp
ENSP00000498029
resolver
ensp
ENSP00000498580
resolver
ensp
ENSP00000637270
resolver
enst
ENST00000648754
resolver
genesymbol
PRDM1
resolver
genesymbol_syn
BLIMP1
resolver
hgnc
HGNC:9346
resolver
uniprot
A0A3B3IU23
resolver
uniprot
B2REA6
resolver
uniprot
B4DW27
resolver
uniprot
E1P5E0
resolver
uniprot
Q86WM7
resolver
uniprot_entry
A0A3B3IU23_HUMAN
resolver
uniprot_entry
B4DW27_HUMAN
resolver
uniprot_entry
PRDM1_HUMAN
resolver
uniprot_sec
B2REA6
resolver
uniprot_sec
E1P5E0
resolver
uniprot_sec
Q86WM7
resolver
amino_acid_sequence
MLDICLEKRVGTTLAAPKCNSSTVRFQGLAEGTKGTMKMDMEDADMTLWTEAEFEEKCTYIVNDHPWDSGADGGTSVQAEASLPRNLLFKYATNSEEVIGVMSKEYIPKGTRFGPLIGEIYTNDTVPKNANRKYFWRIYSRGELHHFIDGFNEEKSNWMRYVNPAHSPREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERLHYPYPGELTMMNLTQTQSSLKQPSTEKNELCPKNVPKREYSVKEILKLDSNPSKGKDLYRSNISPLTSEKDLDDFRRRGSPEMPFYPRVVYPIRAPLPEDFLKASLAYGIERPTYITRSPIPSSTTPSPSARSSPDQSLKSSSPHSSPGNTVSPVGPGSQEHRDSYAYLNASYGTEGLGSYPGYAPLPHLPPAFIPSYNAHYPKFLLPPYGMNCNGLSAVSSMNGINNFGLFPRLCPVYSNLLGGGSLPHPMLNPTSLPSSLPSDGARRLLQPEHPREVLVPAPHSAFSFTGAAASMKDKACSPTSGSPTAGTAATAEHVVQPKATSAAMAAPSSDEAMNLIKNKRNMTGYKTLPYPLKKQNGKIKYECNVCAKTFGQLSNLKVHLRVHSGERPFKCQTCNKGFTQLAHLQKHYLVHTGEKPHECQVCHKRFSSTSNLKTHLRLHSGEKPYQCKVCPAKFTQFVHLKLHKRLHTRERPHKCSQCHKNYIHLCSLKVHLKGNCAAAPAPGLPLEDLTRINEEIEKFDISDNADRLEDVEDDISVISVVEKEILAVVRKEKEETGLKVSLQRNMGNGLLSSGCSLYESSDLPLMKLPPSNPLPLVPVKVKQETVEPMDP
uniprot
proteins
disease_involvement
DISEASE: Note=In certain aggressive cases of activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL), PRDM1 protein instability has been observed. This instability, which impairs B-cell differentiation, is caused by N-terminal misfolding mutations, including those occurring at positions Pro-84 and Ile-107, and results in PRDM1 protein sequestration in the cytoplasm, followed by proteasomal degradation via a heat shock protein 70 HSPA1A-SYNV1/HRD1 pathway. These N-terminal mutations do not affect PRDM1 transcription regulation activity. HSPA1A inhibition restores PRDM1 nuclear localization and transcriptional activity in lymphoma cell lines and suppresses tumor growth in xenografts, more efficiently than proteasome inhibition. {ECO:0000269|PubMed:28842558}.
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (By similarity). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (PubMed:1851123). Drives the maturation of B-lymphocytes into Ig secreting cells (PubMed:12626569). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (By similarity). Binds to the promoter and acts as a transcriptional repressor of IRF8, thereby promotes transcription of osteoclast differentiation factors such as NFATC1 and EEIG1 (By similarity). {ECO:0000250|UniProtKB:Q60636, ECO:0000269|PubMed:12626569, ECO:0000269|PubMed:1851123}.
uniprot
proteins
mass_dalton
91771
uniprot
proteins
mutagenesis
MUTAGEN 84; /note="P->G,K: Protein instability caused by increased susceptibility to proteasomal degradation."; /evidence="ECO:0000269|PubMed:28842558"; MUTAGEN 107; /note="I->G,K: Protein instability caused by increased susceptibility to proteasomal degradation."; /evidence="ECO:0000269|PubMed:28842558
uniprot
proteins
post_translational_modification
PTM: Sumoylation at Lys-816 by PIAS1 augments transcriptional repressor activity, and is critical for plasma cell differentiation (PubMed:22555612). Can be sumoylated with SUMO1 and SUMO2 by PML. Degradation of the wild-type protein mostly depends upon sumoylation, rather than ubiquitination (PubMed:28842558). Desumoylated by SENP1 and SENP6 (PubMed:28842558). {ECO:0000269|PubMed:22555612, ECO:0000269|PubMed:28842558}.; PTM: Ubiquitinated by the SCF(FBXO11) complex, leading to its degradation by the proteasome. {ECO:0000269|PubMed:24613396}.
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
pubmed
12626569
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1851123
uniprot
proteins
pubmed
21421998
uniprot
proteins
pubmed
22555612
uniprot
proteins
pubmed
24613396
uniprot
proteins
pubmed
24968003
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28842558
uniprot
proteins
pubmed
32417234
uniprot
proteins
sequence_length
825
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28842558}. Cytoplasm {ECO:0000269|PubMed:21421998}.
uniprot
proteins