SAE1
entrez
10055
canonical
uniprot
Q9UBE0
canonical
ensembl
ENSG00000142230
resolver
ensp
ENSP00000270225
resolver
ensp
ENSP00000416557
resolver
ensp
ENSP00000440818
resolver
genesymbol
SAE1
resolver
genesymbol_syn
AOS1
resolver
genesymbol_syn
SUA1
resolver
genesymbol_syn
UBLE1A
resolver
hgnc
HGNC:30660
resolver
uniprot
B2RDP5
resolver
uniprot
B3KMQ2
resolver
uniprot
F5GXX7
resolver
uniprot
G3XAK6
resolver
uniprot
O95717
resolver
uniprot
Q9P020
resolver
uniprot_entry
SAE1_HUMAN
resolver
uniprot_sec
B2RDP5
resolver
uniprot_sec
B3KMQ2
resolver
uniprot_sec
F5GXX7
resolver
uniprot_sec
G3XAK6
resolver
uniprot_sec
O95717
resolver
uniprot_sec
Q9P020
resolver
amino_acid_sequence
MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTKVAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDYFLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK
uniprot
proteins
function
FUNCTION: The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269|PubMed:10187858, ECO:0000269|PubMed:10217437, ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:20164921, ECO:0000269|PubMed:9920803}.
uniprot
proteins
mass_dalton
38450
uniprot
proteins
mutagenesis
MUTAGEN 21; /note="R->A: Abolishes ATP-dependent activation of SUMO proteins."; /evidence="ECO:0000269|PubMed:20164921"; MUTAGEN 24..26; /note="RLW->AAA: Abolishes ATP-dependent activation of SUMO proteins."; /evidence="ECO:0000269|PubMed:20164921
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein sumoylation.
uniprot
proteins
protein_family
Ubiquitin-activating E1 family
uniprot
proteins
pubmed
10187858
uniprot
proteins
pubmed
10217437
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
11451954
uniprot
proteins
pubmed
11481243
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15660128
uniprot
proteins
pubmed
16620772
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20164921
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25489052
uniprot
proteins
pubmed
9920803
uniprot
proteins
sequence_length
346
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11481243}.
uniprot
proteins