Dand5
entrez
23863
canonical
uniprot
Q76LW6
canonical
ensembl
ENSMUSG00000053226
resolver
ensp
ENSMUSP00000070057
resolver
enst
ENSMUST00000065539
resolver
genesymbol
Dand5
resolver
genesymbol_syn
Cerl2
resolver
genesymbol_syn
Coco
resolver
genesymbol_syn
Sp1
resolver
uniprot
Q3UPN3
resolver
uniprot_entry
DAND5_MOUSE
resolver
uniprot_entry
Q3UPN3_MOUSE
resolver
amino_acid_sequence
MFRSQFTTLLGLFSGAWLPTGSGRPGAPATPVQSGTAINQSWTLDPLVPISALGSWEAFLGLQNKQQGTGELQGGGQRVAAGVPLPLAPQEVLQETCKALSFVQVISRPGCTSARVLNHLCFGRCSSFYIPSSDPTPVVFCNSCVPARKRWTSVTLWCGAGQLASPRRVRISTVLVQKCQCRPKL
uniprot
proteins
function
FUNCTION: Antagonist of the extracellular signaling protein NODAL, which is required for correct left-right patterning during embryonic development (PubMed:15466485). Antagonist of BMP4 signaling (PubMed:15466485). Antagonist of TGF-beta signaling (By similarity). Independently of its role in left-right axis establishment, plays a role during heart development, possibly through the regulation of TGF-beta/Nodal signaling pathway (PubMed:25033293). Displays anti-angiogenic activity by inhibiting endothelial sprouting, migration, and proliferation (PubMed:33587337). Once internalized by endothelial cells, may alter their redox and glycolytic balance (By similarity). {ECO:0000250|UniProtKB:Q8N907, ECO:0000269|PubMed:15466485, ECO:0000269|PubMed:25033293, ECO:0000269|PubMed:33587337}.
uniprot
proteins
mass_dalton
19772
uniprot
proteins
protein_family
DAN family
uniprot
proteins
pubmed
15466485
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
25033293
uniprot
proteins
pubmed
33587337
uniprot
proteins
pubmed
34210974
uniprot
proteins
pubmed
34531379
uniprot
proteins
sequence_length
185
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Note=Circulating DAND5 may be uptaken by endothelial cells and transported to mitochondria. {ECO:0000250|UniProtKB:Q8N907}.
uniprot
proteins