Inhibition of host IKBKE by virus
uniprot_keyword
KW-1224
canonical
name
Inhibition of host IKBKE by virus
uniprot
definition
Viral protein involved in the evasion of host innate defenses by inhibiting the IKBKE/IKK-epsilon kinase. Upon viral infection, the DDX58/RIG-I or IFIH1/MDA5 receptors recognize foreign material and transmit the signal to downstream components MAVS and IKBKE. In turn, the IKBKE kinase phosphorylates and activates IRF3 and/or IRF7. Once phosphorylated, IRF3 and IRF7 translocate into the nucleus to drive transcription of interferons. Several viruses including arenaviruses or ebola virus interact directly with and inhibit IKBKE/IKK-epsilon to prevent IRFs activation.
uniprot
keywords
is_obsolete
false
uniprot
keywords
ontology_id
uniprot_keywords
uniprot
keywords