IL16
entrez
3603
canonical
uniprot
Q14005
canonical
ensembl
ENSG00000172349
resolver
ensp
ENSP00000302935
resolver
ensp
ENSP00000378147
resolver
ensp
ENSP00000378155
resolver
ensp
ENSP00000453250
resolver
ensp
ENSP00000508085
resolver
ensp
ENSP00000580034
resolver
enst
ENST00000302987
resolver
genesymbol
IL16
resolver
hgnc
HGNC:5980
resolver
uniprot
A0A8C8KBU6
resolver
uniprot
A6NM20
resolver
uniprot
A8MU65
resolver
uniprot
B5TY35
resolver
uniprot
B9EGR6
resolver
uniprot
H3BVH5
resolver
uniprot
Q16435
resolver
uniprot
Q6VVE6
resolver
uniprot
Q6ZMQ7
resolver
uniprot
Q9UME6
resolver
uniprot
Q9UP18
resolver
uniprot_entry
A0A8C8KBU6_HUMAN
resolver
uniprot_entry
IL16_HUMAN
resolver
uniprot_entry
Q9UME6_HUMAN
resolver
uniprot_sec
A6NM20
resolver
uniprot_sec
A8MU65
resolver
uniprot_sec
B5TY35
resolver
uniprot_sec
B9EGR6
resolver
uniprot_sec
H3BVH5
resolver
uniprot_sec
Q16435
resolver
uniprot_sec
Q6VVE6
resolver
uniprot_sec
Q6ZMQ7
resolver
uniprot_sec
Q9UP18
resolver
amino_acid_sequence
MESHSRAGKSRKSAKFRSISRSLMLCNAKTSDDGSSPDEKYPDPFEISLAQGKEGIFHSSVQLADTSEAGPSSVPDLALASEAAQLQAAGNDRGKTCRRIFFMKESSTASSREKPGKLEAQSSNFLFPKACHQRARSNSTSVNPYCTREIDFPMTKKSAAPTDRQPYSLCSNRKSLSQQLDCPAGKAAGTSRPTRSLSTAQLVQPSGGLQASVISNIVLMKGQAKGLGFSIVGGKDSIYGPIGIYVKTIFAGGAAAADGRLQEGDEILELNGESMAGLTHQDALQKFKQAKKGLLTLTVRTRLTAPPSLCSHLSPPLCRSLSSSTCITKDSSSFALESPSAPISTAKPNYRIMVEVSLQKEAGVGLGIGLCSVPYFQCISGIFVHTLSPGSVAHLDGRLRCGDEIVEISDSPVHCLTLNEVYTILSHCDPGPVPIIVSRHPDPQVSEQQLKEAVAQAVENTKFGKERHQWSLEGVKRLESSWHGRPTLEKEREKNSAPPHRRAQKVMIRSSSDSSYMSGSPGGSPGSGSAEKPSSDVDISTHSPSLPLAREPVVLSIASSRLPQESPPLPESRDSHPPLRLKKSFEILVRKPMSSKPKPPPRKYFKSDSDPQKSLEERENSSCSSGHTPPTCGQEARELLPLLLPQEDTAGRSPSASAGCPGPGIGPQTKSSTEGEPGWRRASPVTQTSPIKHPLLKRQARMDYSFDTTAEDPWVRISDCIKNLFSPIMSENHGHMPLQPNASLNEEEGTQGHPDGTPPKLDTANGTPKVYKSADSSTVKKGPPVAPKPAWFRQSLKGLRNRASDPRGLPDPALSTQPAPASREHLGSHIRASSSSSSIRQRISSFETFGSSQLPDKGAQRLSLQPSSGEAAKPLGKHEEGRFSGLLGRGAAPTLVPQQPEQVLSSGSPAASEARDPGVSESPPPGRQPNQKTLPPGPDPLLRLLSTQAEESQGPVLKMPSQRARSFPLTRSQSCETKLLDEKTSKLYSISSQVSSAVMKSLLCLPSSISCAQTPCIPKEGASPTSSSNEDSAANGSAETSALDTGFSLNLSELREYTEGLTEAKEDDDGDHSSLQSGQSVISLLSSEELKKLIEEVKVLDEATLKQLDGIHVTILHKEEGAGLGFSLAGGADLENKVITVHRVFPNGLASQEGTIQKGNEVLSINGKSLKGTTHHDALAILRQAREPRQAVIVTRKLTPEAMPDLNSSTDSAASASAASDVSVESTAEATVCTVTLEKMSAGLGFSLEGGKGSLHGDKPLTINRIFKGAASEQSETVQPGDEILQLGGTAMQGLTRFEAWNIIKALPDGPVTIVIRRKSLQSKETTAAGDS
uniprot
proteins
function
FUNCTION: Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.; FUNCTION: [Isoform 1]: May act as a scaffolding protein that anchors ion channels in the membrane.; FUNCTION: Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
uniprot
proteins
mass_dalton
141752
uniprot
proteins
mutagenesis
MUTAGEN 743; /note="S->A: Reduces phosphorylation and nuclear localization."; /evidence="ECO:0000269|PubMed:12450396"; MUTAGEN 757; /note="T->A: Reduces phosphorylation. Enhances nuclear localization."; /evidence="ECO:0000269|PubMed:12450396"; MUTAGEN 780..781; /note="KK->AA: Reduces nuclear localization of pro-interleukin-16; when associated with 797-AGLANA-802."; /evidence="ECO:0000269|PubMed:11032842"; MUTAGEN 797..802; /note="KGLRNR->AGLANA: Reduces nuclear localization of pro-interleukin-16; when associated with 780-AA-781."; /evidence="ECO:0000269|PubMed:11032842"; MUTAGEN 1211; /note="D->A: Abolishes proteolytic cleavage."; /evidence="ECO:0000269|PubMed:9422780
uniprot
proteins
post_translational_modification
PTM: [Isoform 3]: Synthesized as a chemo-attractant inactive precursor in hemopoietic tissues, and proteolytically cleaved by caspase-3 to yield IL-16. {ECO:0000269|PubMed:9422780}.
uniprot
proteins
pubmed
11032842
uniprot
proteins
pubmed
11276202
uniprot
proteins
pubmed
12450396
uniprot
proteins
pubmed
12620798
uniprot
proteins
pubmed
12923170
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14734747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
18097041
uniprot
proteins
pubmed
19906316
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
7910967
uniprot
proteins
pubmed
8609984
uniprot
proteins
pubmed
9422780
uniprot
proteins
pubmed
9699630
uniprot
proteins
pubmed
9990060
uniprot
proteins
sequence_length
1332
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Interleukin-16]: Secreted.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. Nucleus.
uniprot
proteins