PNMT
entrez
5409
canonical
uniprot
P11086
canonical
ensembl
ENSG00000141744
resolver
ensp
ENSP00000269582
resolver
ensp
ENSP00000377791
resolver
enst
ENST00000269582
resolver
enst
ENST00000394246
resolver
genesymbol
PNMT
resolver
genesymbol_syn
PENT
resolver
hgnc
HGNC:9160
resolver
uniprot
A8MT87
resolver
uniprot_entry
A8MT87_HUMAN
resolver
uniprot_entry
PNMT_HUMAN
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by methyl methanethiosulfonate, phenylglyoxal, tetranitromethane and diethyl pyrocarbonate (PubMed:8812853). Inhibited by 4-oxo-1,4-dihydro-quinoline-3,7-dicarboxylic acid, 4-(benzo[d][1,3]dioxol-5-ylamino)-4-oxobutanoic acid and 1,4-diaminonaphthalene-2,6-disulfonic acid (PubMed:20496117). {ECO:0000269|PubMed:20496117, ECO:0000269|PubMed:8812853}.
uniprot
proteins
amino_acid_sequence
MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRCLAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGAFNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVSAFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVREALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
uniprot
proteins
ec_number
2.1.1.28
uniprot
proteins
function
FUNCTION: Catalyzes the transmethylation of nonepinephrine (noradrenaline) to form epinephrine (adrenaline), using S-adenosyl-L-methionine as the methyl donor (PubMed:20496117). Other substrates include phenylethanolamine and octopamine (PubMed:16277617, PubMed:16363801, PubMed:8812853). Also methylates normetanephrine (By similarity). {ECO:0000250|UniProtKB:P10937, ECO:0000269|PubMed:16277617, ECO:0000269|PubMed:16363801, ECO:0000269|PubMed:20496117, ECO:0000269|PubMed:8812853}.
uniprot
proteins
mass_dalton
30855
uniprot
proteins
mutagenesis
MUTAGEN 35; /note="Y->F: Strongly increases KM for phenylethanolamine and S-adenosyl-L-methionine."; /evidence="ECO:0000269|PubMed:16363801"; MUTAGEN 185; /note="E->A,Q: Strongly reduced enzyme activity towards phenylethanolamine. Increases affinity for S-adenosyl-L-methionine."; /evidence="ECO:0000269|PubMed:16363801"; MUTAGEN 185; /note="E->D: Strongly reduced enzyme activity towards phenylethanolamine. Decreases affinity for phenylethanolamine and S-adenosyl-L-methionine 3-fold."; /evidence="ECO:0000269|PubMed:16363801"; MUTAGEN 219; /note="E->A: Reduced enzyme activity towards phenylethanolamine. Decreases affinity for phenylethanolamine 6-fold. Decreases affinity for S-adenosyl-L-methionine 2-fold."; /evidence="ECO:0000269|PubMed:16363801"; MUTAGEN 267; /note="D->A,N: Strongly reduced enzyme activity towards phenylethanolamine. Decreases affinity for phenylethanolamine 200-fold. Decreases affinity for S-adenosyl-L-methionine 3-fold."; /evidence="ECO:0000269|PubMed:16363801
uniprot
proteins
pathway_participation
PATHWAY: Catecholamine biosynthesis; (R)-adrenaline biosynthesis; (R)-adrenaline from (R)-noradrenaline: step 1/1. {ECO:0000269|PubMed:20496117}.
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
NNMT/PNMT/TEMT family
uniprot
proteins
pubmed
11591352
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16277617
uniprot
proteins
pubmed
16363801
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16942016
uniprot
proteins
pubmed
17845018
uniprot
proteins
pubmed
20496117
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2835776
uniprot
proteins
pubmed
3372503
uniprot
proteins
pubmed
8812853
uniprot
proteins
sequence_length
282
uniprot
proteins