Pank3
entrez
211347
canonical
uniprot
Q8R2W9
canonical
ensembl
ENSMUSG00000018846
resolver
ensp
ENSMUSP00000018990
resolver
enst
ENSMUST00000018990
resolver
genesymbol
Pank3
resolver
uniprot
Q5SXA7
resolver
uniprot_entry
PANK3_MOUSE
resolver
uniprot_entry
Q5SXA7_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Subject to allosteric regulation, exists in two distinct conformational states, a catalytically incompetent (or open) conformation stabilized by the binding of acetyl(acyl)-CoA, and a catalytically competent (or closed) conformation stabilized by ATP-binding (By similarity). Acetyl-CoA and its thioesters act as allosteric inhibitors and compete with the ATP-binding site (By similarity). Strongly inhibited by acetyl-CoA, malonyl-CoA and palmitoyl CoA and modestly inhibited by CoA (PubMed:16040613). Inhibited by calcium hopantenate (PubMed:17379144). {ECO:0000250|UniProtKB:Q9H999, ECO:0000269|PubMed:16040613, ECO:0000269|PubMed:17379144}.
uniprot
proteins
amino_acid_sequence
MKIKDAKKPSFPWFGMDIGGTLVKLSYFEPIDITAEEEQEEVESLKSIRKYLTSNVAYGSTGIRDVHLELKDLTLFGRRGNLHFIRFPTQDLPTFIQMGRDKNFSTLQTVLSATGGGAYKFEKDFRTIGNLHLHKLDELDCLVKGLLYIDSVSFNGQAECYYFANASEPERCQKMPFNLDDPYPLLVVNIGSGVSILAVHSKDNYKRVTGTSLGGGTFLGLCSLLTGCESFEEALEMASKGDSTQADRLVRDIYGGDYERFGLPGWAVASSFGNMIYKEKRETVSKEDLARATLVTITNNIGSVARMCAVNEKINRVVFVGNFLRVNTLSMKLLAYALDYWSKGQLKALFLEHEGYFGAVGALLGLPNFS
uniprot
proteins
ec_number
2.7.1.33
uniprot
proteins
function
FUNCTION: Catalyzes the phosphorylation of pantothenate to generate 4'-phosphopantothenate in the first and rate-determining step of coenzyme A (CoA) synthesis. {ECO:0000269|PubMed:16040613, ECO:0000269|PubMed:17379144}.
uniprot
proteins
mass_dalton
41120
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. {ECO:0000269|PubMed:16040613, ECO:0000269|PubMed:17379144}.
uniprot
proteins
protein_family
Type II pantothenate kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16040613
uniprot
proteins
pubmed
17379144
uniprot
proteins
pubmed
23152917
uniprot
proteins
sequence_length
370
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16040613, ECO:0000269|PubMed:23152917, ECO:0000305}.
uniprot
proteins