Lypd6
entrez
679564
canonical
uniprot
D3ZTT2
canonical
ensembl
ENSRNOG00000085812
resolver
ensembl
ENSRNOG00055001578
resolver
ensembl
ENSRNOG00060032187
resolver
ensembl
ENSRNOG00065008322
resolver
ensp
ENSRNOP00000109366
resolver
ensp
ENSRNOP00055001905
resolver
ensp
ENSRNOP00060046130
resolver
ensp
ENSRNOP00065009769
resolver
enst
ENSRNOT00000173219
resolver
enst
ENSRNOT00055002529
resolver
enst
ENSRNOT00060055771
resolver
enst
ENSRNOT00065013200
resolver
genesymbol
Lypd6
resolver
uniprot_entry
LYPD6_RAT
resolver
amino_acid_sequence
MEPSPALAWLLLLSLVADCLKAAQSRDFTVKDIIYLHPSTTPYPGGFKCFTCEKAADNYECNRWAPDIYCPRDTRYCYTQHTMEVTGNSISVTKRCVPLEECLSTGCRDSEHEGYKICTSCCEGNICNLPLPRNDTDATFATTSPINQTNGHPHCVSVIVSCLWVWLGLTL
uniprot
proteins
function
FUNCTION: Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain (PubMed:27344019). Inhibits nicotine-induced Ca(2+) influx through nAChRs (By similarity). In vitro, specifically inhibits alpha-3:beta-4 and alpha-7 nAChR currents in an allosteric manner (By similarity). Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity). {ECO:0000250|UniProtKB:Q66IA6, ECO:0000250|UniProtKB:Q86Y78, ECO:0000269|PubMed:27344019}.
uniprot
proteins
mass_dalton
19051
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
27344019
uniprot
proteins
pubmed
34631692
uniprot
proteins
sequence_length
171
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q86Y78}. Cytoplasm {ECO:0000250|UniProtKB:Q86Y78}. Cell membrane {ECO:0000269|PubMed:27344019}; Lipid-anchor, GPI-anchor {ECO:0000255}. Synapse, synaptosome {ECO:0000269|PubMed:27344019}. Membrane raft {ECO:0000250|UniProtKB:Q66IA6}. Cell projection, dendrite {ECO:0000269|PubMed:34631692}. Perikaryon {ECO:0000269|PubMed:34631692}. Note=Colocalizes with alpha-3:beta-4- and alpha-7- nicotinic acetylcholine receptors (nAChRs) in the primary cortex and hippocampus. {ECO:0000269|PubMed:34631692}.
uniprot
proteins