IL26
entrez
55801
canonical
uniprot
Q9NPH9
canonical
ensembl
ENSG00000111536
resolver
ensp
ENSP00000229134
resolver
enst
ENST00000229134
resolver
genesymbol
IL26
resolver
genesymbol_syn
AK155
resolver
hgnc
HGNC:17119
resolver
uniprot_entry
IL26_HUMAN
resolver
amino_acid_sequence
MLVNFILRCGLLLVTLSLAIAKHKQSSFTKSCYPRGTLSQAVDALYIKAAWLKATIPEDRIKNIRLLKKKTKKQFMKNCQFQEQLLSFFMEDVFGQLQLQGCKKIRFVEDFHSLRQKLSHCISCASSAREMKSITRMKRIFYRIGNKGIYKAISELDILLSWIKKLLESSQ
uniprot
proteins
function
FUNCTION: May play a role in local mechanisms of mucosal immunity and seems to have a pro-inflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. {ECO:0000269|PubMed:14764663, ECO:0000269|PubMed:15178681, ECO:0000269|PubMed:18483078}.
uniprot
proteins
mass_dalton
19843
uniprot
proteins
protein_family
IL-10 family
uniprot
proteins
pubmed
10729163
uniprot
proteins
pubmed
14764663
uniprot
proteins
pubmed
15178681
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18483078
uniprot
proteins
sequence_length
171
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18483078}.
uniprot
proteins