Anp32a
entrez
11737
canonical
uniprot
O35381
canonical
ensembl
ENSMUSG00000032249
resolver
ensp
ENSMUSP00000082652
resolver
ensp
ENSMUSP00000122165
resolver
enst
ENSMUST00000085519
resolver
enst
ENSMUST00000135395
resolver
genesymbol
Anp32a
resolver
genesymbol_syn
Anp32
resolver
genesymbol_syn
Lanp
resolver
uniprot
D3Z7M9
resolver
uniprot
P97437
resolver
uniprot_entry
AN32A_MOUSE
resolver
uniprot_entry
D3Z7M9_MOUSE
resolver
uniprot_sec
P97437
resolver
amino_acid_sequence
MEMDKRIYLELRNRTPSDVKELVLDNCKSIEGKIEGLTDEFEELEFLSTINVGLTSISNLPKLNKLKKLELSENRISGDLEVLAEKCPNLKHLNLSGNKIKDLSTIEPLKKLENLKSLDLFNCEVTNLNAYRENVFKLLPQVMYLDGYDRDNKEAPDSDVEGYVEDDDEEDEDEEEYDEYAQLVEDEEEEDEEEEGEEEDVSGEEEEDEEGYNDGEVDDEEDEEEAGEEEGSQKRKREPDDEGEEDD
uniprot
proteins
function
FUNCTION: Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription. Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation. In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltransferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking. Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition (PubMed:29467488). Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A (By similarity) (PubMed:17557114, PubMed:29467488). {ECO:0000250|UniProtKB:P39687, ECO:0000269|PubMed:17557114, ECO:0000269|PubMed:29467488}.
uniprot
proteins
mass_dalton
28538
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine residues, at least in part by casein kinase 2/CK2. {ECO:0000250|UniProtKB:P39687}.; PTM: Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group.
uniprot
proteins
protein_family
ANP32 family
uniprot
proteins
pubmed
12807913
uniprot
proteins
pubmed
15060138
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15895553
uniprot
proteins
pubmed
17557114
uniprot
proteins
pubmed
19524510
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29467488
uniprot
proteins
pubmed
8970164
uniprot
proteins
pubmed
9353121
uniprot
proteins
sequence_length
247
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12807913}. Cytoplasm {ECO:0000269|PubMed:12807913}. Endoplasmic reticulum {ECO:0000250}. Note=Shuttles between nucleus and cytoplasm. Translocates to the cytoplasm during the process of neuritogenesis.
uniprot
proteins