Tab2
entrez
68652
canonical
uniprot
Q99K90
canonical
ensembl
ENSMUSG00000015755
resolver
ensp
ENSMUSP00000121266
resolver
ensp
ENSMUSP00000300073
resolver
enst
ENSMUST00000146444
resolver
genesymbol
Tab2
resolver
genesymbol_syn
Kiaa0733
resolver
genesymbol_syn
Map3k7ip2
resolver
uniprot
Q3UGP1
resolver
uniprot
Q8BTP4
resolver
uniprot
Q8CHD3
resolver
uniprot
Q99KP4
resolver
uniprot_entry
TAB2_MOUSE
resolver
uniprot_sec
Q3UGP1
resolver
uniprot_sec
Q8BTP4
resolver
uniprot_sec
Q8CHD3
resolver
uniprot_sec
Q99KP4
resolver
amino_acid_sequence
MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDLNFSDESGISGLRNHMTSLNLDLQSQNVYHHGREGSRVNGSRTLTHSVSDGQLHGGQSNNELFQQEPQTAPAQVPQGFNVFGMPSTSGASNSTPHLGFHLGSKGTSNLSQQTPRFNPIMVTLAPNIQTGRSTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPSGTARQTQQHSGWVSQFNPMNPQQAYQPSQPGPWTTYPASNPLPHTSTQQPNQQGHQTSHVYMPISSPTTPQPPTIHSSGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNSSSKLRSSGPRTASTSSLVNSQTLNRNQPTVYIAASPPNTDEMISRSQPKVYISANATAGDEQGMRNQPTLFISTNSGPSAASRNMSGQVSMGPAFIHHHPPKSRVLGGNSATSPRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTFELTNLLNHPDHYVETENIQHLTDPALAHVDRISEARKLSMGSDDAAYTQALLVHQKARMERLQRELEMQKKKLDKLKSEVNEMENNLTRRRLKRSNSISQIPSLEEMQQLRSCNRQLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSTIKAPKTQDAEDEEGAQWNCTACTFLNHPALIRCEQCEMPRHF
uniprot
proteins
function
FUNCTION: Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF) (By similarity). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains (By similarity). The RanBP2-type zinc finger (NZF) specifically recognizes 'Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (PubMed:19927120). Also recognizes and binds Lys-63'-linked polyubiquitin chains of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (By similarity). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (PubMed:12150997). Involved in heart development (By similarity). {ECO:0000250|UniProtKB:Q9NYJ8, ECO:0000269|PubMed:12150997, ECO:0000269|PubMed:19927120}.
uniprot
proteins
mass_dalton
76442
uniprot
proteins
mutagenesis
MUTAGEN 674; /note="T->A: Loss of interaction with 'Lys-63'-linked ubiquitin."; /evidence="ECO:0000269|PubMed:19927120"; MUTAGEN 675; /note="F->A: Loss of interaction with 'Lys-63'-linked ubiquitin."; /evidence="ECO:0000269|PubMed:19927120"; MUTAGEN 678; /note="H->Q: Loss of interaction with 'Lys-63'-linked ubiquitin."; /evidence="ECO:0000269|PubMed:19927120"; MUTAGEN 681; /note="L->T: Loss of interaction with 'Lys-63'-linked ubiquitin."; /evidence="ECO:0000269|PubMed:19927120"; MUTAGEN 685; /note="E->V: Loss of interaction with 'Lys-63'-linked ubiquitin."; /evidence="ECO:0000269|PubMed:19927120"; MUTAGEN 686; /note="Q->I,M: Confers ability to bind monoubiquitin and polyubiquitin, irrespective of the type of linkage."; /evidence="ECO:0000269|PubMed:19927120
uniprot
proteins
post_translational_modification
PTM: SUMOylated by TRIM60; leading to inhibition of MAPK/NF-kappaB activation and the innate immune response. {ECO:0000250|UniProtKB:Q9NYJ8}.; PTM: Ubiquitinated; following IL1 stimulation or TRAF6 overexpression. Ubiquitination involves RBCK1 leading to proteasomal degradation. Ubiquitinated at Lys-611 by TRIM45 leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q9NYJ8}.; PTM: Degraded in a lysosome-dependent manner following interaction with TRIM38. {ECO:0000250|UniProtKB:Q9NYJ8}.; PTM: Phosphorylated. {ECO:0000305|PubMed:12150997}.
uniprot
proteins
pubmed
12150997
uniprot
proteins
pubmed
12465718
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19927120
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
693
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9NYJ8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9NYJ8}. Endosome membrane {ECO:0000250|UniProtKB:Q9NYJ8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9NYJ8}. Lysosome membrane {ECO:0000250|UniProtKB:Q9NYJ8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9NYJ8}. Cytoplasm, cytosol {ECO:0000269|PubMed:12150997}. Nucleus {ECO:0000269|PubMed:12150997}. Note=Following IL1 stimulation, translocation occurs from the membrane to cytosol. Interaction with TRIM38 promotes translocation from cytosol to endosome and lysosome. {ECO:0000250|UniProtKB:Q9NYJ8}.
uniprot
proteins