Slc16a1
entrez
20501
canonical
uniprot
P53986
canonical
ensembl
ENSMUSG00000032902
resolver
ensp
ENSMUSP00000045216
resolver
enst
ENSMUST00000046212
resolver
genesymbol
Slc16a1
resolver
genesymbol_syn
Mct1
resolver
uniprot
Q544N9
resolver
uniprot_entry
MOT1_MOUSE
resolver
uniprot_entry
Q544N9_MOUSE
resolver
amino_acid_sequence
MPPAIGGPVGYTPPDGGWGWAVLVGAFISIGFSYAFPKSITVFFKEIEVIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGLIAASFCNTVQELYLCIGVIGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQAFFDIFDWRGSFLILGGLLLNCCVAGSLMRPIGPEQVKLEKLKSKESLQEAGKSDANTDLIGGSPKGEKLSVFQTINKFLDLSLFTHRGFLLYLSGNVVMFFGLFTPLVFLSSYGKSKDFSSEKSAFLLSILAFVDMVARPSMGLAANTKWIRPRIQYFFAASVVANGVCHLLAPLSTTYVGFCVYAGVFGFAFGWLSSVLFETLMDLIGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVILIIAGIYLFIGMGINYRLLAKEQKAEEKQKREGKEDEASTDVDEKPKETMKAAQSPQQHSSGDPTEEESPV
uniprot
proteins
function
FUNCTION: Bidirectional proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH (By similarity). The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate. MCT1 is a major lactate exporter (By similarity). Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (PubMed:22522610, PubMed:24367518). Facilitates the protonated monocarboxylate form of succinate export, that its transient protonation upon muscle cell acidification in exercising muscle and ischemic heart. Functions via alternate outward- and inward-open conformation states. Protonation and deprotonation of 302-Asp is essential for the conformational transition (PubMed:32946811). {ECO:0000250|UniProtKB:P53985, ECO:0000250|UniProtKB:P53987, ECO:0000269|PubMed:22522610, ECO:0000269|PubMed:24367518, ECO:0000269|PubMed:32946811}.
uniprot
proteins
mass_dalton
53267
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Monocarboxylate porter (TC 2.A.1.13) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
17208939
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21792931
uniprot
proteins
pubmed
22522610
uniprot
proteins
pubmed
24367518
uniprot
proteins
pubmed
32946811
uniprot
proteins
pubmed
8603082
uniprot
proteins
pubmed
9725820
uniprot
proteins
sequence_length
493
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21792931, ECO:0000269|PubMed:8603082}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P53985}. Basolateral cell membrane {ECO:0000250|UniProtKB:P53987}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P53985}. Apical cell membrane {ECO:0000250|UniProtKB:P53985}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P53985}. Note=Expression at the cell surface requires the ancillary proteins BSG and EMB. {ECO:0000250|UniProtKB:P53985}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..44; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P53985"; TRANSMEM 56..80; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P53985"; TRANSMEM 85..105; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P53985"; TRANSMEM 110..132; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P53985"; TRANSMEM 147..169; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P53985"; TRANSMEM 175..194; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P53985"; TRANSMEM 255..281; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P53985"; TRANSMEM 289..310; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P53985"; TRANSMEM 322..342; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:P53985"; TRANSMEM 347..368; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:P53985"; TRANSMEM 383..403; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:P53985"; TRANSMEM 415..436; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:P53985
uniprot
proteins