Spx
entrez
319552
canonical
uniprot
D3Z752
canonical
ensembl
ENSMUSG00000071112
resolver
ensp
ENSMUSP00000118062
resolver
ensp
ENSMUSP00000147302
resolver
enst
ENSMUST00000126521
resolver
enst
ENSMUST00000211094
resolver
genesymbol
Spx
resolver
uniprot
A0A1C7CYU9
resolver
uniprot_entry
A0A1C7CYU9_MOUSE
resolver
uniprot_entry
SPXN_MOUSE
resolver
amino_acid_sequence
MKGPSVLAVTAVVLLLVLSALENSSGAPQRLSEKRNWTPQAMLYLKGAQGRRFLSDQSRRKELADRPPPERRNPDLELLTLPEAAALFLASLEKSQKDEGGNFDKSELLEDRLFNW
uniprot
proteins
function
FUNCTION: Plays a role as a central modulator of cardiovascular and renal function and nociception. Also plays a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (By similarity). {ECO:0000250}.; FUNCTION: [Spexin-1]: Acts as a ligand for galanin receptors GALR2 and GALR3. Intracerebroventricular administration of the peptide induces an increase in arterial blood pressure, a decrease in both heart rate and renal excretion and delayed natriuresis. Intraventricular administration of the peptide induces antinociceptive activity. Also induces contraction of muscarinic-like stomach smooth muscles (By similarity). Intraperitoneal administration of the peptide induces a reduction in food consumption and body weight. Inhibits long chain fatty acid uptake into adipocytes (PubMed:24550067). {ECO:0000250, ECO:0000269|PubMed:24550067}.; FUNCTION: [Spexin-2]: Intracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate. Intraventricular administration of the peptide induces antinociceptive activity (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
13004
uniprot
proteins
protein_family
Spexin family
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
24550067
uniprot
proteins
sequence_length
116
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24550067}. Secreted, extracellular space {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Note=Secreted via the classical ER/Golgi-dependent pathway into the extracellular medium largely as a full-length protein without the signal peptide, and not as a hydrolyzed and amidated peptide. Localized extracellularly surrounding the villous trophoblastic cells (By similarity). Detected in the serum. {ECO:0000250}.
uniprot
proteins