Atp6v0c
entrez
170667
canonical
uniprot
P63081
canonical
ensembl
ENSRNOG00055026526
resolver
ensembl
ENSRNOG00060010175
resolver
ensembl
ENSRNOG00065010290
resolver
ensp
ENSRNOP00055037525
resolver
ensp
ENSRNOP00060013346
resolver
ensp
ENSRNOP00065012663
resolver
enst
ENSRNOT00055045776
resolver
enst
ENSRNOT00060017175
resolver
enst
ENSRNOT00065016620
resolver
genesymbol
Atp6v0c
resolver
genesymbol_syn
Atp6c
resolver
genesymbol_syn
Atp6l
resolver
genesymbol_syn
Atpl
resolver
uniprot
P23967
resolver
uniprot_entry
VATL_RAT
resolver
uniprot_sec
P23967
resolver
amino_acid_sequence
MADIKNNPEYSSFFGVMGASSAMVFSAMGAAYGTAKSGTGIAAMSVMRPELIMKSIIPVVMAGIIAIYGLVVAVLIANSLTDGITLYRSFLQLGAGLSVGLSGLAAGFAIGIVGDAGVRGTAQQPRLFVGMILILIFAEVLGLYGLIVALILSTK
uniprot
proteins
function
FUNCTION: Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32165585). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (PubMed:32165585). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity). {ECO:0000250|UniProtKB:P27449, ECO:0000269|PubMed:32165585}.
uniprot
proteins
mass_dalton
15808
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by RNF182, leading to its degradation via the ubiquitin-proteasome pathway. {ECO:0000250|UniProtKB:P27449}.
uniprot
proteins
protein_family
V-ATPase proteolipid subunit family
uniprot
proteins
pubmed
1400263
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
32165585
uniprot
proteins
sequence_length
155
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269|PubMed:32165585}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:32165585}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:P27449}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 11..33; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 56..76; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 93..114; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 132..152; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins