TLE1
entrez
7088
canonical
uniprot
Q04724
canonical
ensembl
ENSG00000196781
resolver
ensp
ENSP00000365682
resolver
ensp
ENSP00000549139
resolver
ensp
ENSP00000549140
resolver
ensp
ENSP00000549141
resolver
ensp
ENSP00000549142
resolver
ensp
ENSP00000549143
resolver
ensp
ENSP00000549144
resolver
ensp
ENSP00000549145
resolver
ensp
ENSP00000549149
resolver
ensp
ENSP00000616485
resolver
ensp
ENSP00000616486
resolver
ensp
ENSP00000616487
resolver
ensp
ENSP00000616488
resolver
ensp
ENSP00000616494
resolver
ensp
ENSP00000616495
resolver
ensp
ENSP00000616497
resolver
ensp
ENSP00000616499
resolver
ensp
ENSP00000616501
resolver
ensp
ENSP00000616502
resolver
ensp
ENSP00000644926
resolver
enst
ENST00000376499
resolver
genesymbol
TLE1
resolver
hgnc
HGNC:11837
resolver
uniprot
A8K495
resolver
uniprot
B4DEF9
resolver
uniprot
Q59EF7
resolver
uniprot
Q5T3G4
resolver
uniprot
Q969V9
resolver
uniprot_entry
B4DEF9_HUMAN
resolver
uniprot_entry
Q59EF7_HUMAN
resolver
uniprot_entry
TLE1_HUMAN
resolver
uniprot_sec
A8K495
resolver
uniprot_sec
Q5T3G4
resolver
uniprot_sec
Q969V9
resolver
amino_acid_sequence
MFPQSRHPTPHQAAGQPFKFTIPESLDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTICAQVIPFLSQEHQQQVAQAVERAKQVTMAELNAIIGQQQLQAQHLSHGHGPPVPLTPHPSGLQPPGIPPLGGSAGLLALSSALSGQSHLAIKDDKKHHDAEHHRDREPGTSNSLLVPDSLRGTDKRRNGPEFSNDIKKRKVDDKDSSHYDSDGDKSDDNLVVDVSNEDPSSPRASPAHSPRENGIDKNRLLKKDASSSPASTASSASSTSLKSKEMSLHEKASTPVLKSSTPTPRSDMPTPGTSATPGLRPGLGKPPAIDPLVNQAAAGLRTPLAVPGPYPAPFGMVPHAGMNGELTSPGAAYASLHNMSPQMSAAAAAAAVVAYGRSPMVGFDPPPHMRVPTIPPNLAGIPGGKPAYSFHVTADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHVNKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY
uniprot
proteins
function
FUNCTION: Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression (By similarity). The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. {ECO:0000250|UniProtKB:Q62440, ECO:0000269|PubMed:10660609}.
uniprot
proteins
mass_dalton
83201
uniprot
proteins
mutagenesis
MUTAGEN 486; /note="V->S: Abolishes HESX1 binding."; /evidence="ECO:0000269|PubMed:11731482"; MUTAGEN 532; /note="Y->H: Abolishes HESX1 binding."; /evidence="ECO:0000269|PubMed:11731482"; MUTAGEN 702; /note="L->S: Abolishes HESX1 binding."; /evidence="ECO:0000269|PubMed:11731482"; MUTAGEN 715; /note="S->P: Abolishes HESX1 binding."; /evidence="ECO:0000269|PubMed:11731482
uniprot
proteins
post_translational_modification
PTM: Phosphorylated, probably by CDK1. The degree of phosphorylation varies throughout the cell cycle, and is highest at the G2/M transition. Becomes hyperphosphorylated in response to cell differentiation and interaction with HES1 or RUNX1.; PTM: Ubiquitinated by XIAP/BIRC4. {ECO:0000269|PubMed:22304967}.
uniprot
proteins
protein_family
WD repeat Groucho/TLE family
uniprot
proteins
pubmed
10660609
uniprot
proteins
pubmed
10748198
uniprot
proteins
pubmed
11731482
uniprot
proteins
pubmed
12057191
uniprot
proteins
pubmed
12397081
uniprot
proteins
pubmed
12441302
uniprot
proteins
pubmed
1303260
uniprot
proteins
pubmed
14651967
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18254933
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21429299
uniprot
proteins
pubmed
22304967
uniprot
proteins
pubmed
8649374
uniprot
proteins
pubmed
8687460
uniprot
proteins
pubmed
9334241
uniprot
proteins
pubmed
9751710
uniprot
proteins
pubmed
9854018
uniprot
proteins
pubmed
9874198
uniprot
proteins
sequence_length
770
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12397081}. Note=Nuclear and chromatin-associated, depending on isoforms and phosphorylation status. Hyperphosphorylation decreases the affinity for nuclear components.
uniprot
proteins