Rgs14
entrez
114705
canonical
uniprot
O08773
canonical
ensembl
ENSRNOG00000015616
resolver
ensembl
ENSRNOG00055015587
resolver
ensembl
ENSRNOG00060017717
resolver
ensembl
ENSRNOG00065022867
resolver
ensp
ENSRNOP00000021596
resolver
ensp
ENSRNOP00055021566
resolver
ensp
ENSRNOP00060024536
resolver
ensp
ENSRNOP00065031773
resolver
enst
ENSRNOT00000021596
resolver
enst
ENSRNOT00055026588
resolver
enst
ENSRNOT00060030379
resolver
enst
ENSRNOT00065039119
resolver
genesymbol
Rgs14
resolver
uniprot_entry
RGS14_RAT
resolver
amino_acid_sequence
MPGKPKHLGVPNGRMVLAVSDGELTSTSGSQAQGEGRGSSLSIHSLPSGPSSPFSTDEQPVASWAQSFERLLQDPRGLAYFTEFLKKEFSAENVTFWQACERFQQIPASDTKQLAQEAHNIYHEFLSSQALSPVNIDRQAWLSEEVLAQPRPDMFRAQQLQIFNLMKFDSYARFVKSPLYQECLLAEAEGRPLREPGSSHLGSPDTARKKPKLKPGKSLPLGVEELGQLPLAEGRPLRKSFRREMPGGAVNSALRRESQGSLNSSASLDLGFLAFVSSKSESHRKSLGSGEGESESRPGKYCCVYLPDGTASLALARPGLTIRDMLAGICEKRGLSLPDIKVYLVGKEQKALVLDQDCTVLADQEVRLENRITFQLELVGLERVVRISAKPTKRLQEALQPILAKHGLSLDQVVLHRPGEKQLVDLENLVSSVASQTLVLDTLPDAKTREASSIPPCRSQGCLPRTQTKDSHLPPLSSSLSVEDASGSTGKRQTCDIEGLVELLNRVQSSGAHDQRGLLRKEDLVLPEFLQLPSQRPGSQEAPP
uniprot
proteins
function
FUNCTION: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modulates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor (GDI) (PubMed:11976690). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o)-alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor (PDGF)-stimulated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modulator of microtubule polymerization and spindle organization through a G(i)-alpha-dependent mechanism. Plays a role in cell division; required for completion of the first mitotic division of the embryo. Involved in visual memory processing capacity; when overexpressed in the V2 secondary visual cortex area. Involved in hippocampal-based learning and memory; acts as a suppressor of synaptic plasticity in CA2 neurons. Required for the nerve growth factor (NGF)-mediated neurite outgrowth. Involved in stress resistance. {ECO:0000269|PubMed:11387333, ECO:0000269|PubMed:11976690, ECO:0000269|PubMed:15337739, ECO:0000269|PubMed:19319189, ECO:0000269|PubMed:19574389, ECO:0000269|PubMed:19878719, ECO:0000269|PubMed:21158412, ECO:0000269|PubMed:21255223}.
uniprot
proteins
mass_dalton
59492
uniprot
proteins
mutagenesis
MUTAGEN 258; /note="S->A: Inhibits phosphorylation; when associated with A-494."; /evidence="ECO:0000269|PubMed:12534294"; MUTAGEN 333; /note="R->L: Abolishes the inhibition of PDGF-mediated ERK1/ERK2 phosphorylation. Inhibits interaction with HRAS and does not colocalize with active GTP-bound form of HRAS at membranes. Does not inhibit interaction with BRAF or RAF1."; /evidence="ECO:0000269|PubMed:19878719"; MUTAGEN 406; /note="H->A: Does not inhibit interaction and colocalization with active GTP-bound form of HRAS at membranes. Does not inhibit interaction with BRAF or RAF1."; /evidence="ECO:0000269|PubMed:19878719"; MUTAGEN 494; /note="T->A: Does not increase the GDI activity against GNAI1. Does not alter GTPase activity against GNAO1 or GNAI1. Inhibits phosphorylation; when associated with A-258."; /evidence="ECO:0000269|PubMed:12534294"; MUTAGEN 494; /note="T->D: Increases the GDI activity against GNAI1. Does not alter GTPase activity against GNAO1 or GNAI1."; /evidence="ECO:0000269|PubMed:12534294"; MUTAGEN 494; /note="T->E: Increases the GDI activity against GNAI1. Does not alter GTPase activity against GNAO1 or GNAI1."; /evidence="ECO:0000269|PubMed:12534294"; MUTAGEN 508; /note="Q->L: Inhibits the interaction with GNAI1."; /evidence="ECO:0000269|PubMed:17603074"; MUTAGEN 518; /note="L->Y: Increases the interaction with GNAI1."; /evidence="ECO:0000269|PubMed:17603074"; MUTAGEN 525; /note="V->W: Increases the interaction with GNAI1."; /evidence="ECO:0000269|PubMed:17603074"; MUTAGEN 529; /note="F->W: Increases the interaction with GNAI1."; /evidence="ECO:0000269|PubMed:17603074
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKC. Phosphorylation is increased in presence of forskolin and may enhance the GDI activity on G(i) alpha subunit GNAI1. {ECO:0000269|PubMed:12534294}.
uniprot
proteins
pubmed
11387333
uniprot
proteins
pubmed
11976690
uniprot
proteins
pubmed
12534294
uniprot
proteins
pubmed
15337739
uniprot
proteins
pubmed
16819986
uniprot
proteins
pubmed
16870394
uniprot
proteins
pubmed
17603074
uniprot
proteins
pubmed
19319189
uniprot
proteins
pubmed
19574389
uniprot
proteins
pubmed
19878719
uniprot
proteins
pubmed
21158412
uniprot
proteins
pubmed
21255223
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9168931
uniprot
proteins
sequence_length
544
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Nucleus, PML body {ECO:0000250}. Cytoplasm. Membrane. Cell membrane. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Postsynaptic density {ECO:0000250}. Note=Associates with the perinuclear sheaths of microtubules (MTs) surrounding the pronuclei, prior to segregating to the anastral mitotic apparatus and subsequently the barrel-shaped cytoplasmic bridge between the nascent nuclei of the emerging 2-cell embryo. Localizes to a perinuclear compartment near the microtubule-organizing center (MTOC). Expressed in the nucleus during interphase and segregates to the centrosomes and astral MTs during mitosis. Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner. Relocalizes to the nucleus in PML nuclear bodies in respons to heat stress. Colocalizes with RIC8A in CA2 hippocampal neurons (By similarity). Localizes with spindle poles during metaphase. Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner. Recruited from the cytosol to the plasma membrane by the inactive GDP-bound forms of G(i) alpha subunits GNAI1 and GNAI3. Recruited from the cytosol to membranes by the active GTP-bound form of HRAS. Colocalizes with G(i) alpha subunit GNAI1 and RIC8A at the plasma membrane. Colocalizes with BRAF and RAF1 in both the cytoplasm and membranes. {ECO:0000250}.
uniprot
proteins