Dtx1
entrez
14357
canonical
uniprot
Q61010
canonical
ensembl
ENSMUSG00000029603
resolver
ensp
ENSMUSP00000031607
resolver
ensp
ENSMUSP00000291126
resolver
ensp
ENSMUSP00000291132
resolver
ensp
ENSMUSP00000291133
resolver
ensp
ENSMUSP00000332040
resolver
genesymbol
Dtx1
resolver
uniprot
Q3TER5
resolver
uniprot
Q8C2H2
resolver
uniprot
Q9ER09
resolver
uniprot_entry
DTX1_MOUSE
resolver
uniprot_sec
Q3TER5
resolver
uniprot_sec
Q8C2H2
resolver
uniprot_sec
Q9ER09
resolver
amino_acid_sequence
MSRPGQGVMVPVNGLGFPPQNVARVVVWEWLNEHSRWRPYTATVCHHIENVLKEDARGSVVLGQVDAQLVPYIIDLQSMHQFRQDTGTMRPVRRNFYDPSSAPGKGIVWEWENDGGAWTAYDMDICITIQNAYEKQHPWLDLSSLGFCYLIYFNSMSQMNRQTRRRRRLRRRLDLAYPLTVGSIPKSQSWPVGASSGQPCSCQQCLLVNSTRAASNAILASQRRKAPIAPAAPPAPPPPPPPLPPGGPPGALVVRPSATFAGAALWAAPATGPTEPAPPPGVPPRSPSAPNGAPTPGQNNLSRPGPQRSTSVSARASIPPGVPALPVKNLNGTGPVHPALAGMTGILLCAAGLPVCLTRAPKPILHPPPVSKSDVKPVPGVPGVCRKTKKKHLKKSKNPEDVVRRYMQKVKNPPDEDCTICMERLVTASGYEGVLRNKSVRPELVGRLGRCGHMYHLLCLVAMYSNGNKDGSLQCPTCKAIYGEKTGTQPPGKMEFHLIPHSLPGFADTQTIRIVYDIPTGIQGPEHPNPGKKFTARGFPRHCYLPNNEKGRKVLRLLITAWERRLIFTIGTSNTTGESDTVVWNEIHHKTEFGSNLTGHGYPDASYLDNVLAELTAQGVSEAMAKA
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination and proteasomal degradation of MEKK1, thereby modulating signaling pathways involved in cell fate determination (PubMed:15684388). Regulates the Notch signaling pathway, acting predominantly as a positive regulator but functioning as a context-dependent negative regulator in specific developmental or cellular settings. Mediates the antineural activity of Notch signaling, likely by inhibiting transcriptional activation mediated by MATCH1. Negatively regulates Notch signaling by controlling the activity of PIP4K2C, a lipid kinase that promotes recycling of Notch receptors from RAB4A-positive endosomes to the cell surface. Participates in several developmental and immune processes, including neurogenesis, lymphogenesis, and myogenesis. Influences lymphocyte differentiation by promoting B-cell development at the expense of T-cell development, suggesting functional antagonism of NOTCH1 in this context. Also promotes degradation of PRKCQ via the endosome-lysosome pathway, contributing to PKCtheta down-regulation during T-cell anergy. In addition, facilitates differentiation of Th17 cells by inducing expression and DNA-binding activity of RORgT (By similarity). {ECO:0000250|UniProtKB:Q86Y01, ECO:0000269|PubMed:15684388, ECO:0000269|PubMed:32736174}.
uniprot
proteins
mass_dalton
68119
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; undergoes 'Lys-29'-linked polyubiquitination catalyzed by ITCH. {ECO:0000250|UniProtKB:Q86Y01}.
uniprot
proteins
protein_family
Deltex family
uniprot
proteins
pubmed
11226752
uniprot
proteins
pubmed
11731257
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15684388
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
32736174
uniprot
proteins
pubmed
8853908
uniprot
proteins
sequence_length
627
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q86Y01}. Nucleus {ECO:0000250|UniProtKB:Q86Y01}. Note=Predominantly cytoplasmic. Associates with endocytic vesicles. Partially nuclear. {ECO:0000250|UniProtKB:Q86Y01}.
uniprot
proteins