Fhit
entrez
14198
canonical
uniprot
O89106
canonical
ensembl
ENSMUSG00000060579
resolver
ensp
ENSMUSP00000123874
resolver
ensp
ENSMUSP00000124017
resolver
ensp
ENSMUSP00000124073
resolver
ensp
ENSMUSP00000124957
resolver
ensp
ENSMUSP00000136011
resolver
enst
ENSMUST00000160340
resolver
enst
ENSMUST00000161302
resolver
enst
ENSMUST00000162278
resolver
enst
ENSMUST00000179394
resolver
genesymbol
Fhit
resolver
uniprot
E9PZ91
resolver
uniprot
Q6URW5
resolver
uniprot
Q91VL1
resolver
uniprot_entry
E9PZ91_MOUSE
resolver
uniprot_entry
FHIT_MOUSE
resolver
uniprot_sec
Q6URW5
resolver
uniprot_sec
Q91VL1
resolver
amino_acid_sequence
MSFRFGQHLIKPSVVFLKTELSFALVNRKPVVPGHVLVCPLRPVERFRDLHPDEVADLFQVTQRVGTVVEKHFQGTSITFSMQDGPEAGQTVKHVHVHVLPRKAGDFPRNDNIYDELQKHDREEEDSPAFWRSEKEMAAEAEALRVYFQA
uniprot
proteins
ec_number
2.7.7.51
uniprot
proteins
ec_number
3.6.1.29
uniprot
proteins
ec_number
3.6.2.1
uniprot
proteins
ec_number
3.9.1.-
uniprot
proteins
function
FUNCTION: Possesses dinucleoside triphosphate hydrolase activity (By similarity). Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP (By similarity). Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP (By similarity). Exhibits adenylylsulfatase activity, hydrolyzing adenosine 5'-phosphosulfate to yield AMP and sulfate (By similarity). Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (By similarity). Exhibits adenylylsulfate-ammonia adenylyltransferase, catalyzing the ammonolysis of adenosine 5'-phosphosulfate resulting in the formation of adenosine 5'-phosphoramidate (By similarity). Also catalyzes the ammonolysis of adenosine 5-phosphorofluoridate and diadenosine triphosphate (By similarity). Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5 (By similarity). Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways (By similarity). Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis (By similarity). Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity (By similarity). Functions as a tumor suppressor (PubMed:10758156, PubMed:11517343). {ECO:0000250|UniProtKB:P49789, ECO:0000269|PubMed:10758156, ECO:0000269|PubMed:11517343}.
uniprot
proteins
mass_dalton
17235
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Tyr-114 by SRC is required for induction of apoptosis. {ECO:0000250|UniProtKB:P49789}.
uniprot
proteins
pubmed
10758156
uniprot
proteins
pubmed
11517343
uniprot
proteins
pubmed
14630947
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9671749
uniprot
proteins
pubmed
9699672
uniprot
proteins
sequence_length
150
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9699672}. Nucleus {ECO:0000250|UniProtKB:P49789}. Mitochondrion {ECO:0000250|UniProtKB:P49789}.
uniprot
proteins