Psmb3
entrez
29676
canonical
uniprot
P40112
canonical
ensembl
ENSRNOG00000052730
resolver
ensembl
ENSRNOG00055032642
resolver
ensembl
ENSRNOG00060026200
resolver
ensembl
ENSRNOG00065031097
resolver
ensp
ENSRNOP00000089407
resolver
ensp
ENSRNOP00055046514
resolver
ensp
ENSRNOP00060037798
resolver
ensp
ENSRNOP00065044123
resolver
enst
ENSRNOT00000112080
resolver
enst
ENSRNOT00055056408
resolver
enst
ENSRNOT00060045527
resolver
enst
ENSRNOT00065053676
resolver
genesymbol
Psmb3
resolver
uniprot_entry
PSB3_RAT
resolver
amino_acid_sequence
MSVMSYNGGAVMAMKGKNCVAIAADRRFGIQAQMVTTDFQKIFPMGDRLYIGLAGLATDVQTVAQRLKFRLNLYELKEGRQIKPYTLMSMVANLLYEKRFGPYYTEPVIAGLDPKTFKPFICSLDLIGCPMVTDDFVVSGTCSEQMYGMCESLWEPNMDPEHLFETISQAMLNAVDRDAVSGMGVIVHIIEKDKITTRTLKARMD
uniprot
proteins
function
FUNCTION: Non-catalytic component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000250|UniProtKB:P49720}.
uniprot
proteins
mass_dalton
22965
uniprot
proteins
protein_family
Peptidase T1B family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8282111
uniprot
proteins
sequence_length
205
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P49720}. Nucleus {ECO:0000250|UniProtKB:P49720}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000250|UniProtKB:P49720}.
uniprot
proteins