SULT1A1
entrez
6817
canonical
uniprot
P50225
canonical
ensembl
ENSG00000196502
resolver
ensp
ENSP00000321988
resolver
ensp
ENSP00000456459
resolver
ensp
ENSP00000457912
resolver
ensp
ENSP00000568614
resolver
ensp
ENSP00000568623
resolver
ensp
ENSP00000568631
resolver
ensp
ENSP00000627398
resolver
ensp
ENSP00000650037
resolver
ensp
ENSP00000726405
resolver
genesymbol
SULT1A1
resolver
genesymbol_syn
STP
resolver
genesymbol_syn
STP1
resolver
hgnc
HGNC:11453
resolver
uniprot
Q2NL71
resolver
uniprot
Q86U58
resolver
uniprot
Q92818
resolver
uniprot
Q9BVU6
resolver
uniprot
Q9UGG7
resolver
uniprot_entry
ST1A1_HUMAN
resolver
uniprot_sec
Q2NL71
resolver
uniprot_sec
Q86U58
resolver
uniprot_sec
Q92818
resolver
uniprot_sec
Q9BVU6
resolver
uniprot_sec
Q9UGG7
resolver
amino_acid_sequence
MELIQDTSRPPLEYVKGVPLIKYFAEALGPLQSFQARPDDLLISTYPKSGTTWVSQILDMIYQGGDLEKCHRAPIFMRVPFLEFKAPGIPSGMETLKDTPAPRLLKTHLPLALLPQTLLDQKVKVVYVARNAKDVAVSYYHFYHMAKVHPEPGTWDSFLEKFMVGEVSYGSWYQHVQEWWELSRTHPVLYLFYEDMKENPKREIQKILEFVGRSLPEETVDFVVQHTSFKEMKKNPMTNYTTVPQEFMDHSISPFMRKGMAGDWKTTFTVAQNERFDADYAEKMAGCSLSFRSEL
uniprot
proteins
ec_number
2.8.2.1
uniprot
proteins
function
FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine group. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds. Plays an important role in the sulfonation of endogenous molecules such as steroid hormones (PubMed:12471039, PubMed:16221673, PubMed:21723874, PubMed:22069470, PubMed:7834621). Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil (By similarity). Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (PubMed:7834621). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system (PubMed:35165440). Catalyzes the sulfate conjugation of dopamine (PubMed:8093002). Catalyzes the sulfation of T4 (L-thyroxine/3,5,3',5'-tetraiodothyronine), T3 (3,5,3'-triiodothyronine), rT3 (3,3',5'-triiodothyronine) and 3,3'-T2 (3,3'-diiodothyronine), with a substrate preference of 3,3'-T2 > rT3 > T3 > T4 (PubMed:10199779). {ECO:0000250|UniProtKB:P17988, ECO:0000269|PubMed:10199779, ECO:0000269|PubMed:12471039, ECO:0000269|PubMed:16221673, ECO:0000269|PubMed:21723874, ECO:0000269|PubMed:22069470, ECO:0000269|PubMed:35165440, ECO:0000269|PubMed:7834621, ECO:0000269|PubMed:8093002}.
uniprot
proteins
mass_dalton
34165
uniprot
proteins
mutagenesis
MUTAGEN 70; /note="C->S: Increased sensitivity of enzyme activity to heat inactivation."; /evidence="ECO:0000269|PubMed:8033270"; MUTAGEN 249; /note="D->G: Increased activity towards p-nitrophenol."; /evidence="ECO:0000269|PubMed:22069470
uniprot
proteins
protein_family
Sulfotransferase 1 family
uniprot
proteins
pubmed
10199779
uniprot
proteins
pubmed
10762004
uniprot
proteins
pubmed
12471039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
16221673
uniprot
proteins
pubmed
20417180
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21723874
uniprot
proteins
pubmed
22069470
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
35165440
uniprot
proteins
pubmed
7581483
uniprot
proteins
pubmed
7695643
uniprot
proteins
pubmed
7834621
uniprot
proteins
pubmed
7864863
uniprot
proteins
pubmed
8033246
uniprot
proteins
pubmed
8033270
uniprot
proteins
pubmed
8093002
uniprot
proteins
pubmed
8288252
uniprot
proteins
pubmed
8363592
uniprot
proteins
pubmed
8423770
uniprot
proteins
pubmed
8484775
uniprot
proteins
pubmed
8912648
uniprot
proteins
pubmed
8924211
uniprot
proteins
pubmed
9345314
uniprot
proteins
pubmed
9855620
uniprot
proteins
sequence_length
295
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8093002}.
uniprot
proteins