TSPAN5
entrez
10098
canonical
uniprot
P62079
canonical
ensembl
ENSG00000168785
resolver
ensp
ENSP00000307701
resolver
ensp
ENSP00000421808
resolver
ensp
ENSP00000423916
resolver
ensp
ENSP00000522799
resolver
ensp
ENSP00000687132
resolver
enst
ENST00000305798
resolver
enst
ENST00000505184
resolver
enst
ENST00000508798
resolver
genesymbol
TSPAN5
resolver
genesymbol_syn
TM4SF9
resolver
hgnc
HGNC:17753
resolver
uniprot
B2RDY2
resolver
uniprot
B7Z317
resolver
uniprot
D6RAR1
resolver
uniprot
F6UJH9
resolver
uniprot
O60628
resolver
uniprot
O60746
resolver
uniprot
Q6FHE5
resolver
uniprot
Q9JLY1
resolver
uniprot_entry
B7Z317_HUMAN
resolver
uniprot_entry
D6RAR1_HUMAN
resolver
uniprot_entry
F6UJH9_HUMAN
resolver
uniprot_entry
TSN5_HUMAN
resolver
uniprot_sec
B2RDY2
resolver
uniprot_sec
O60628
resolver
uniprot_sec
O60746
resolver
uniprot_sec
Q6FHE5
resolver
uniprot_sec
Q9JLY1
resolver
amino_acid_sequence
MSGKHYKGPEVSCCIKYFIFGFNVIFWFLGITFLGIGLWAWNEKGVLSNISSITDLGGFDPVWLFLVVGGVMFILGFAGCIGALRENTFLLKFFSVFLGIIFFLELTAGVLAFVFKDWIKDQLYFFINNNIRAYRDDIDLQNLIDFTQEYWQCCGAFGADDWNLNIYFNCTDSNASRERCGVPFSCCTKDPAEDVINTQCGYDARQKPEVDQQIVIYTKGCVPQFEKWLQDNLTIVAGIFIGIALLQIFGICLAQNLVSDIEAVRASW
uniprot
proteins
function
FUNCTION: Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell surface as well as substrate specificity. Different TspanC8/ADAM10 complexes have distinct substrates (PubMed:26686862, PubMed:28600292, PubMed:37516108). Promotes ADAM10-mediated cleavage of CD44 (PubMed:26686862). Seems to regulate VE-cadherin expression in endothelial cells probably through interaction with ADAM10, promoting leukocyte transmigration (PubMed:28600292). {ECO:0000269|PubMed:26686862, ECO:0000269|PubMed:28600292, ECO:0000269|PubMed:37516108}.
uniprot
proteins
mass_dalton
30337
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. {ECO:0000269|PubMed:31792032}.
uniprot
proteins
protein_family
Tetraspanin (TM4SF) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
26686862
uniprot
proteins
pubmed
28600292
uniprot
proteins
pubmed
31792032
uniprot
proteins
pubmed
37516108
uniprot
proteins
pubmed
9714763
uniprot
proteins
sequence_length
268
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26686862, ECO:0000269|PubMed:31792032}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 18..38; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 62..82; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 93..113; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 233..253; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins