DESI2
entrez
51029
canonical
uniprot
Q9BSY9
canonical
ensembl
ENSG00000121644
resolver
ensp
ENSP00000263831
resolver
ensp
ENSP00000306528
resolver
ensp
ENSP00000788889
resolver
genesymbol
DESI2
resolver
genesymbol_syn
C1orf121
resolver
genesymbol_syn
FAM152A
resolver
genesymbol_syn
PPPDE1
resolver
hgnc
HGNC:24264
resolver
uniprot
B1APK6
resolver
uniprot
Q5VVC6
resolver
uniprot
Q9NYS2
resolver
uniprot
Q9Y3E4
resolver
uniprot_entry
DESI2_HUMAN
resolver
uniprot_sec
B1APK6
resolver
uniprot_sec
Q5VVC6
resolver
uniprot_sec
Q9NYS2
resolver
uniprot_sec
Q9Y3E4
resolver
activity_regulation
ACTIVITY REGULATION: Palmostatin B inhibits its palmitoyl protein thioesterase activity. {ECO:0000269|PubMed:35427157}.
uniprot
proteins
amino_acid_sequence
MGANQLVVLNVYDMYWMNEYTSSIGIGVFHSGIEVYGREFAYGGHPYPFSGIFEISPGNASELGETFKFKEAVVLGSTDFLEDDIEKIVEELGKEYKGNAYHLMHKNCNHFSSALSEILCGKEIPRWINRLAYFSSCIPFLQSCLPKEWLTPAALQSSVSQELQDELEEAEDAAASASVASTAAGSRPGRHTKL
uniprot
proteins
ec_number
3.1.2.22
uniprot
proteins
ec_number
3.4.19.12
uniprot
proteins
function
FUNCTION: Has deubiquitinating activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Deubiquitinates 'Lys-48'-linked polyubiquitination of RPS7 leading to its stabilization (PubMed:28483520). Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity towards synthetic substrates 4-methylumbelliferyl-6-S-palmitoyl-beta-D-glucopyranoside and S-depalmitoylation probe 5 (DPP-5) (PubMed:35427157). {ECO:0000269|PubMed:28483520, ECO:0000269|PubMed:35427157}.
uniprot
proteins
mass_dalton
21444
uniprot
proteins
mutagenesis
MUTAGEN 108; /note="C->S: Loss of deubiquitination activity."; /evidence="ECO:0000269|PubMed:28483520
uniprot
proteins
protein_family
DeSI family
uniprot
proteins
pubmed
10810093
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
28483520
uniprot
proteins
pubmed
35427157
uniprot
proteins
sequence_length
194
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9D291}.
uniprot
proteins