Mdfi
entrez
17240
canonical
uniprot
P70331
canonical
ensembl
ENSMUSG00000032717
resolver
ensp
ENSMUSP00000037888
resolver
ensp
ENSMUSP00000069915
resolver
ensp
ENSMUSP00000108905
resolver
enst
ENSMUST00000113280
resolver
genesymbol
Mdfi
resolver
uniprot
D3Z6Q8
resolver
uniprot
P70330
resolver
uniprot
P70332
resolver
uniprot
Q5XK64
resolver
uniprot
Q99JM9
resolver
uniprot_entry
D3Z6Q8_MOUSE
resolver
uniprot_entry
MDFI_MOUSE
resolver
uniprot_sec
P70330
resolver
uniprot_sec
P70332
resolver
uniprot_sec
Q5XK64
resolver
uniprot_sec
Q99JM9
resolver
amino_acid_sequence
MSQVSGQCPSRCDAPHGVPSAALDPAQTMSLLPGLEVARSTHPVEASSEEGFPEEAAPSMPHDSGLRAQQALNSIDLDVPTEAVTCQPQGNPQGCTPLLPNGSSHDHLSEPGSAGHAGNGALGGSKAHRKLQTHPSLGSQAGRKSRGSARSASQVPLQAQEGKAPAVRIHRQTASPTCCLRNAQLSGTALRSLRLESQGHRELNNKTLSQSNNKKPGVAAHAAIIPALTRPKQNCHDPSLLPGTHGVGKEF
uniprot
proteins
function
FUNCTION: Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis (PubMed:8797820). Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals (PubMed:8797820). Can also interfere with the DNA-binding activity of Myod family members (PubMed:8797820). Plays an important role in trophoblast and chondrogenic differentiation (PubMed:9799236). Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with Tcf7l1/Tcf3 and preventing it from binding DNA (PubMed:11238923). Binds to the axin complex, resulting in an increase in the level of free beta-catenin (PubMed:12192039). Affects axin regulation of the WNT and JNK signaling pathways (PubMed:12192039). Regulates the activity of mechanosensitive Piezo channel (PubMed:37590348). {ECO:0000269|PubMed:11238923, ECO:0000269|PubMed:12192039, ECO:0000269|PubMed:37590348, ECO:0000269|PubMed:8797820, ECO:0000269|PubMed:9799236}.
uniprot
proteins
mass_dalton
26013
uniprot
proteins
protein_family
MDFI family
uniprot
proteins
pubmed
11238923
uniprot
proteins
pubmed
12192039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
37590348
uniprot
proteins
pubmed
8797820
uniprot
proteins
pubmed
9799236
uniprot
proteins
sequence_length
251
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm {ECO:0000269|PubMed:37590348}.
uniprot
proteins