Rac3
entrez
170758
canonical
uniprot
P60764
canonical
ensembl
ENSMUSG00000018012
resolver
ensp
ENSMUSP00000018156
resolver
enst
ENSMUST00000018156
resolver
genesymbol
Rac3
resolver
uniprot
O14658
resolver
uniprot
Q14A12
resolver
uniprot_entry
Q14A12_MOUSE
resolver
uniprot_entry
RAC3_MOUSE
resolver
uniprot_sec
O14658
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. Regulated by the GEF protein DOCK7. {ECO:0000250|UniProtKB:P60763}.
uniprot
proteins
amino_acid_sequence
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPHTPILLVGTKLDLRDDKDTIERLRDKKLAPITYPQGLAMAREIGSVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKPGKKCTVF
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner. {ECO:0000250|UniProtKB:P60763}.
uniprot
proteins
mass_dalton
21379
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated at Lys-166 in a FBXL19-mediated manner; leading to proteasomal degradation. {ECO:0000250|UniProtKB:P60763}.
uniprot
proteins
protein_family
Rho family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
192
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P60763}. Endomembrane system {ECO:0000250|UniProtKB:P60763}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P60763}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P60763}. Cell membrane {ECO:0000250|UniProtKB:P60763}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P60763}. Note=Membrane-associated when activated. Localizes to actin-based membrane ruffles (By similarity). Colocalizes with NRBP to endomembranes and at the cell periphery in lamellipodia. Colocalized with CIB1 in the perinuclear area and at the cell periphery. {ECO:0000250|UniProtKB:P60763}.
uniprot
proteins