Slc33a1
entrez
11416
canonical
uniprot
Q99J27
canonical
ensembl
ENSMUSG00000027822
resolver
ensp
ENSMUSP00000029402
resolver
ensp
ENSMUSP00000123986
resolver
ensp
ENSMUSP00000125713
resolver
enst
ENSMUST00000029402
resolver
enst
ENSMUST00000160883
resolver
enst
ENSMUST00000161659
resolver
genesymbol
Slc33a1
resolver
genesymbol_syn
Acatn
resolver
uniprot
Q9WTN1
resolver
uniprot_entry
ACATN_MOUSE
resolver
uniprot_sec
Q9WTN1
resolver
amino_acid_sequence
MSPTISHKDSSRQRRSGMFSHALDMKSGPLPPGGWDDSRRDSVGGEGDREVLLGDAGPGDLPKAPRSYRSELSSILLLLFLYVLQGIPLGLAGSIPLILQSKNVSYTDQAFFSFVFWPFSLKLLWAPLVDAVYFKNFGRRKSWLVPTQYTLGIFMIYLSTQVDRLLGNIDGRTPDVVALTVTFFLFEFLAATQDIAVDGWALTMLSRENVGYASTCNSVGQTAGYFLGNVLFLALESADFCNKYLRFQPQPRGIVTLSDFLFFWGTVFLITTTLVALLKKENREASIVKEETQGITDTYKLLFSIIKMPAVLAFCLLILTSKIGFSAADAVTGLKLVEEGVPKEHLALLAVPMVPLQIILPLLISKYTAGPQPLNIFYKAMPYRLLLGLEYALLVWWTPKVEHQGGFPLYYYIIVLLSYALHQVTLYSMYVSIMAFNAKVSDPLIGGTYMTLLNTVSNLGGNWPSTVALWLVDPLTVKECVGASNQNCRTPDAIELCKKLGGSCVTALDGYYVESIICVLIGFGWWFFLGPKFKKLQDEGPSSWKCKRNN
uniprot
proteins
function
FUNCTION: Acetyl-CoA transporter that mediates active acetyl-CoA import through the endoplasmic reticulum (ER) membrane into the ER lumen where specific ER-based acetyl-CoA:lysine acetyltransferases are responsible for the acetylation of ER-based protein substrate, such as BACE1 (PubMed:24828632). Necessary for O-acetylation of gangliosides (PubMed:10570973). {ECO:0000250|UniProtKB:O00400, ECO:0000269|PubMed:10570973, ECO:0000269|PubMed:24828632}.
uniprot
proteins
mass_dalton
61075
uniprot
proteins
mutagenesis
MUTAGEN 113; /note="S->R: Mice homozygous for the mutation display early developmental arrest. Heterozygous animals display a deregulated form of autophagy."; /evidence="ECO:0000269|PubMed:24828632
uniprot
proteins
protein_family
SLC33A transporter family
uniprot
proteins
pubmed
10570973
uniprot
proteins
pubmed
10812068
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17208939
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
20826464
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24828632
uniprot
proteins
sequence_length
550
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O00400}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 75..95; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 114..134; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 142..162; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 176..196; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 218..238; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 257..277; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 301..321; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 345..365; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 376..396; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 406..426; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 510..530; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins