Gdpd4
entrez
233537
canonical
uniprot
Q3TT99
canonical
ensembl
ENSMUSG00000035582
resolver
ensp
ENSMUSP00000036772
resolver
ensp
ENSMUSP00000131960
resolver
enst
ENSMUST00000041860
resolver
enst
ENSMUST00000170049
resolver
genesymbol
Gdpd4
resolver
genesymbol_syn
Gde6
resolver
uniprot
Q8BI25
resolver
uniprot_entry
GDE6_MOUSE
resolver
uniprot_sec
Q8BI25
resolver
amino_acid_sequence
MEETQDSSSSKPKNTDENFSLWIEQYFNHKCCITFLTGCYSCQWQYREWEKTELGSCCCSRKEQFFYMCLVIAFILSVLFLFVWVETSNEYNGFDWVVYLGTGCWFFWSILVLSAAGIMVAYTTLLLLLGFLLLWERIELNLHTSHKVFICLVIVLCSFLLAVLSHFWKDKWLIAGLSLQIFAPFVHLSLITVMIIISWPLSICVARLESEVKVRRYRMADYEQEIQERCNVFQRLRALQIAAGLSFLIILLCLYLMPLGIYSPCILKKENLGPKPTLFGHRGAPMLAPENTMMSFEKAVELDVSGLETDIYLSFDSVPFLMHDYDLTRTTNIKEVLPSAAGNHTSNFNWTFLSTLNAGKWFLKHKPFFGMKPLSEADKRRAGNQSIPQLSELLALAKREQKIVIFDLFGPRPGHPLRNTFVRRVVKVILDSKIEQRLIFWLPGFDRDYVRFMAPGFQHVGRLWSIKDLTKHNITIINVDYKRLFYAGLRDYKEAKIYIHVYVINEPWLFSLAWCSSINSVTTDNIELLNQLSRPLFFMTPGFYMFMWLFLDIASAVIIGFVFCYNWIKEIKRERWLEAAASSGLLHSETITDITENNDASQQKPEVAPTSANLAPENMIELQKTEPKTENL
uniprot
proteins
ec_number
3.1.4.-
uniprot
proteins
function
FUNCTION: Ecto-phospholipase that cleaves the phosphodiester bond in the glycosylphosphatidylinositol (GPI) anchor of TRABD2A and TRABD2B, releasing them from the plasma membrane. The release in the extracellular space inactivates these metalloproteases involved in the negative regulation of Wnt signaling. {ECO:0000250|UniProtKB:Q6W3E5}.
uniprot
proteins
mass_dalton
73220
uniprot
proteins
protein_family
Glycerophosphoryl diester phosphodiesterase family
uniprot
proteins
pubmed
15276213
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
632
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6W3E5}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 65..85; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 115..135; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 148..168; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 181..201; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 241..261; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 543..563; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins