MAPK10
entrez
5602
canonical
uniprot
P53779
canonical
ensembl
ENSG00000109339
resolver
ensp
ENSP00000352157
resolver
ensp
ENSP00000414469
resolver
ensp
ENSP00000422277
resolver
ensp
ENSP00000425654
resolver
ensp
ENSP00000491866
resolver
ensp
ENSP00000492484
resolver
ensp
ENSP00000492809
resolver
ensp
ENSP00000492886
resolver
ensp
ENSP00000492913
resolver
ensp
ENSP00000492922
resolver
ensp
ENSP00000492972
resolver
ensp
ENSP00000493040
resolver
ensp
ENSP00000493204
resolver
ensp
ENSP00000493206
resolver
ensp
ENSP00000493215
resolver
ensp
ENSP00000493237
resolver
ensp
ENSP00000493259
resolver
ensp
ENSP00000493309
resolver
ensp
ENSP00000493329
resolver
ensp
ENSP00000493344
resolver
ensp
ENSP00000493373
resolver
ensp
ENSP00000493395
resolver
ensp
ENSP00000493435
resolver
ensp
ENSP00000555493
resolver
enst
ENST00000359221
resolver
enst
ENST00000449047
resolver
enst
ENST00000512689
resolver
enst
ENST00000639972
resolver
enst
ENST00000640490
resolver
enst
ENST00000641120
resolver
enst
ENST00000641208
resolver
enst
ENST00000641237
resolver
enst
ENST00000641313
resolver
enst
ENST00000641430
resolver
enst
ENST00000641537
resolver
enst
ENST00000641553
resolver
enst
ENST00000641555
resolver
enst
ENST00000641718
resolver
enst
ENST00000641767
resolver
enst
ENST00000641831
resolver
enst
ENST00000641989
resolver
enst
ENST00000642032
resolver
enst
ENST00000885434
resolver
genesymbol
MAPK10
resolver
genesymbol_syn
JNK3
resolver
genesymbol_syn
JNK3A
resolver
genesymbol_syn
PRKM10
resolver
genesymbol_syn
SAPK1B
resolver
hgnc
HGNC:6872
resolver
uniprot
A0A286YEQ0
resolver
uniprot
A0A286YF97
resolver
uniprot
A6NFS3
resolver
uniprot
A6NG28
resolver
uniprot
B3KQ94
resolver
uniprot
D6RJF9
resolver
uniprot
F8W9R5
resolver
uniprot
Q15707
resolver
uniprot
Q499Y8
resolver
uniprot
Q49AP1
resolver
uniprot_entry
A0A286YEQ0_HUMAN
resolver
uniprot_entry
A0A286YF97_HUMAN
resolver
uniprot_entry
D6RJF9_HUMAN
resolver
uniprot_entry
F8W9R5_HUMAN
resolver
uniprot_entry
MK10_HUMAN
resolver
uniprot_entry
Q499Y8_HUMAN
resolver
uniprot_sec
A6NFS3
resolver
uniprot_sec
A6NG28
resolver
uniprot_sec
B3KQ94
resolver
uniprot_sec
Q15707
resolver
uniprot_sec
Q49AP1
resolver
activity_regulation
ACTIVITY REGULATION: Activated by threonine and tyrosine phosphorylation by two dual specificity kinases, MAP2K4 and MAP2K7. MAP2K7 phosphorylates MAPK10 on Thr-221 causing a conformational change and a large increase in Vmax. MAP2K4 then phosphorylates Tyr-223 resulting in a further increase in Vmax. Inhibited by dual specificity phosphatases, such as DUSP1. Inhibited by HDAC9. {ECO:0000269|PubMed:11062067, ECO:0000269|PubMed:16611996}.
uniprot
proteins
amino_acid_sequence
MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving MAPK10 has been found in a single patient with pharmacoresistant epileptic encephalopathy. Translocation t(Y;4)(q11.2;q21) which causes MAPK10 truncation. {ECO:0000269|PubMed:16249883}.
uniprot
proteins
ec_number
2.7.11.24
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Also participates in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (PubMed:22327296). {ECO:0000269|PubMed:11718727, ECO:0000269|PubMed:22327296, ECO:0000269|PubMed:22441692}.
uniprot
proteins
mass_dalton
52585
uniprot
proteins
mutagenesis
MUTAGEN 462; /note="C->S: Loss of palmitoylation."; /evidence="ECO:0000269|PubMed:21941371"; MUTAGEN 463; /note="C->S: Loss of palmitoylation."; /evidence="ECO:0000269|PubMed:21941371
uniprot
proteins
post_translational_modification
PTM: Dually phosphorylated on Thr-221 and Tyr-223 by MAP2K4 and MAP2K7, which activates the enzyme. MAP2K7 shows a strong preference for Thr-221 while MAP2K4 phosphorylates Tyr-223 preferentially. Weakly autophosphorylated on threonine and tyrosine residues in vitro. {ECO:0000269|PubMed:10715136}.; PTM: Palmitoylation regulates subcellular location and axonal development. {ECO:0000269|PubMed:21941371}.
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
MAP kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10715136
uniprot
proteins
pubmed
11062067
uniprot
proteins
pubmed
11718727
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15693750
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16249883
uniprot
proteins
pubmed
16611996
uniprot
proteins
pubmed
16737965
uniprot
proteins
pubmed
18435604
uniprot
proteins
pubmed
21941371
uniprot
proteins
pubmed
22327296
uniprot
proteins
pubmed
22441692
uniprot
proteins
pubmed
7826642
uniprot
proteins
pubmed
8654373
uniprot
proteins
pubmed
9739089
uniprot
proteins
sequence_length
464
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16737965}. Membrane {ECO:0000269|PubMed:16737965}; Lipid-anchor {ECO:0000269|PubMed:16737965}. Nucleus {ECO:0000269|PubMed:16737965}. Mitochondrion {ECO:0000269|PubMed:16737965}. Note=Palmitoylation regulates MAPK10 trafficking to cytoskeleton. Recruited to the mitochondria in the presence of SARM1 (By similarity). {ECO:0000250}.
uniprot
proteins