Majin
entrez
499306
canonical
uniprot
Q6AYM7
canonical
ensembl
ENSRNOG00000054336
resolver
ensembl
ENSRNOG00055022168
resolver
ensembl
ENSRNOG00060032633
resolver
ensembl
ENSRNOG00065028506
resolver
ensp
ENSRNOP00000072946
resolver
ensp
ENSRNOP00055031079
resolver
ensp
ENSRNOP00060046727
resolver
ensp
ENSRNOP00065040323
resolver
enst
ENSRNOT00000077274
resolver
enst
ENSRNOT00055038110
resolver
enst
ENSRNOT00060056561
resolver
enst
ENSRNOT00065049173
resolver
genesymbol
Majin
resolver
uniprot_entry
MAJIN_RAT
resolver
amino_acid_sequence
MSLKPFTYPFPETRFLHAGTNVYKFKIRYGNSIRGEEIEDKGVIIQELEDSIRAVLANMDSLQPFVTEHFIVFPYKSKWERVSHLKFKHGEIILTPYPFVFTLYIEMKCFAESLPSGKPTDDIPLELVLTAKEAEEATMRKRKLMEEPSTPSRPGPHRAKMETWSEASSTKKALKEHKRSWGEDSQQDTPASDSTAVTEQDPMLGHSLPGLVVPPLEHSNPPPLKEPAARGFLGFLSALFPFRYFFRKSTQ
uniprot
proteins
function
FUNCTION: Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane. {ECO:0000250|UniProtKB:Q9D992}.
uniprot
proteins
mass_dalton
28646
uniprot
proteins
protein_family
MAJIN family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
251
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000250|UniProtKB:Q9D992}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9D992}. Chromosome, telomere {ECO:0000250|UniProtKB:Q9D992}. Note=In leptotene spermatocytes, localizes to telomeres that localize to the nucleus inner membrane. {ECO:0000250|UniProtKB:Q9D992}.
uniprot
proteins
transmembrane_region
TRANSMEM 228..246; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins