GATA3
entrez
2625
canonical
uniprot
P23771
canonical
ensembl
ENSG00000107485
resolver
ensp
ENSP00000341619
resolver
ensp
ENSP00000368632
resolver
ensp
ENSP00000542654
resolver
ensp
ENSP00000625871
resolver
genesymbol
GATA3
resolver
hgnc
HGNC:4172
resolver
uniprot
Q5VWG7
resolver
uniprot
Q5VWG8
resolver
uniprot
Q96J16
resolver
uniprot_entry
GATA3_HUMAN
resolver
uniprot_sec
Q5VWG7
resolver
uniprot_sec
Q5VWG8
resolver
uniprot_sec
Q96J16
resolver
amino_acid_sequence
MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLSHSYMDAAQYPLPEEVDVLFNIDGQGNHVPPYYGNSVRATVQRYPPTHHGSQVCRPPLLHGSLPWLDGGKALGSHHTASPWNLSPFSKTSIHHGSPGPLSVYPPASSSSLSGGHASPHLFTFPPTPPKDVSPDPSLSTPGSAGSARQDEKECLKYQVPLPDSMKLESSHSRGSMTALGGASSSTHHPITTYPPYVPEYSSGLFPPSSLLGGSPTGFGCKSRPKARSSTGRECVNCGATSTPLWRRDGTGHYLCNACGLYHKMNGQNRPLIKPKRRLSAARRAGTSCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNINRPLTMKKEGIQTRNRKMSSKSKKCKKVHDSLEDFPKNSSFNPAALSRHMSSLSHISPFSHSSHMLTTPTPMHPPSSLSFGPHHPSSMVTAMG
uniprot
proteins
disease_involvement
DISEASE: Hypoparathyroidism, sensorineural deafness, and renal disease (HDR) [MIM:146255]: A disease characterized by steroid-resistant nephrosis with progressive renal failure, hypoparathyroidism, sensorineural deafness, and renal dysplasia. {ECO:0000269|PubMed:10935639, ECO:0000269|PubMed:11389161, ECO:0000269|PubMed:26514990}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression (By similarity). Coordinates macrophage transcriptional activation and UCP2-dependent metabolic reprogramming in response to IL33. Upon tissue injury, acts downstream of IL33 signaling to drive differentiation of inflammation-resolving alternatively activated macrophages. {ECO:0000250|UniProtKB:P23772, ECO:0000269|PubMed:23824597}.
uniprot
proteins
mass_dalton
47916
uniprot
proteins
pubmed
10935639
uniprot
proteins
pubmed
11389161
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15662016
uniprot
proteins
pubmed
17224074
uniprot
proteins
pubmed
1827068
uniprot
proteins
pubmed
1871134
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
2017177
uniprot
proteins
pubmed
2050118
uniprot
proteins
pubmed
23142663
uniprot
proteins
pubmed
23824597
uniprot
proteins
pubmed
26514990
uniprot
proteins
sequence_length
443
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins