TDRD1
entrez
56165
canonical
uniprot
Q9BXT4
canonical
ensembl
ENSG00000095627
resolver
ensp
ENSP00000251864
resolver
ensp
ENSP00000358286
resolver
ensp
ENSP00000358288
resolver
ensp
ENSP00000511878
resolver
ensp
ENSP00000530314
resolver
ensp
ENSP00000530315
resolver
ensp
ENSP00000622610
resolver
enst
ENST00000369280
resolver
enst
ENST00000369282
resolver
enst
ENST00000952551
resolver
genesymbol
TDRD1
resolver
hgnc
HGNC:11712
resolver
uniprot
A0A140VJW6
resolver
uniprot
A6NEN3
resolver
uniprot
A6NMN2
resolver
uniprot
B3KVI4
resolver
uniprot
B4E2L5
resolver
uniprot
D3DRC2
resolver
uniprot
H9KV62
resolver
uniprot
H9KV63
resolver
uniprot
Q4G0Y8
resolver
uniprot
Q6P518
resolver
uniprot
Q9H7B3
resolver
uniprot_entry
A0A140VJW6_HUMAN
resolver
uniprot_entry
H9KV62_HUMAN
resolver
uniprot_entry
H9KV63_HUMAN
resolver
uniprot_entry
TDRD1_HUMAN
resolver
uniprot_sec
A6NEN3
resolver
uniprot_sec
A6NMN2
resolver
uniprot_sec
B3KVI4
resolver
uniprot_sec
B4E2L5
resolver
uniprot_sec
D3DRC2
resolver
uniprot_sec
Q4G0Y8
resolver
uniprot_sec
Q6P518
resolver
uniprot_sec
Q9H7B3
resolver
amino_acid_sequence
MSVKSPFNVMSRNNLEAPPCKMTEPFNFEKNENKLPPHESLRSPGTLPNHPNFRLKSSENGNKKNNFLLCEQTKQYLASQEDNSVSSNPNGINGEVVGSKGDRKKLPAGNSVSPPSAESNSPPKEVNIKPGNNVRPAKSKKLNKLVENSLSISNPGLFTSLGPPLRSTTCHRCGLFGSLRCSQCKQTYYCSTACQRRDWSAHSIVCRPVQPNFHKLENKSSIETKDVEVNNKSDCPLGVTKEIAIWAERIMFSDLRSLQLKKTMEIKGTVTEFKHPGDFYVQLYSSEVLEYMNQLSASLKETYANVHEKDYIPVKGEVCIAKYTVDQTWNRAIIQNVDVQQKKAHVLYIDYGNEEIIPLNRIYHLNRNIDLFPPCAIKCFVANVIPAEGNWSSDCIKATKPLLMEQYCSIKIVDILEEEVVTFAVEVELPNSGKLLDHVLIEMGYGLKPSGQDSKKENADQSDPEDVGKMTTENNIVVDKSDLIPKVLTLNVGDEFCGVVAHIQTPEDFFCQQLQSGRKLAELQASLSKYCDQLPPRSDFYPAIGDICCAQFSEDDQWYRASVLAYASEESVLVGYVDYGNFEILSLMRLCPIIPKLLELPMQAIKCVLAGVKPSLGIWTPEAICLMKKLVQNKIITVKVVDKLENSSLVELIDKSETPHVSVSKVLLDAGFAVGEQSMVTDKPSDVKETSVPLGVEGKVNPLEWTWVELGVDQTVDVVVCVIYSPGEFYCHVLKEDALKKLNDLNKSLAEHCQQKLPNGFKAEIGQPCCAFFAGDGSWYRALVKEILPNGHVKVHFVDYGNIEEVTADELRMISSTFLNLPFQGIRCQLADIQSRNKHWSEEAITRFQMCVAGIKLQARVVEVTENGIGVELTDLSTCYPRIISDVLIDEHLVLKSASPHKDLPNDRLVNKHELQVHVQGLQATSSAEQWKTIELPVDKTIQANVLEIISPNLFYALPKGMPENQEKLCMLTAELLEYCNAPKSRPPYRPRIGDACCAKYTSDDFWYRAVVLGTSDTDVEVLYADYGNIETLPLCRVQPITSSHLALPFQIIRCSLEGLMELNGSSSQLIIMLLKNFMLNQNVMLSVKGITKNVHTVSVEKCSENGTVDVADKLVTFGLAKNITPQRQSALNTEKMYRMNCCCTELQKQVEKHEHILLFLLNNSTNQNKFIEMKKLLKS
uniprot
proteins
function
FUNCTION: Plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Required for the localization of Piwi proteins to the meiotic nuage. Involved in the piRNA metabolic process by ensuring the entry of correct transcripts into the normal piRNA pool and limiting the entry of cellular transcripts into the piRNA pathway. May act by allowing the recruitment of piRNA biogenesis or loading factors that ensure the correct entry of transcripts and piRNAs into Piwi proteins (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
132024
uniprot
proteins
protein_family
TDRD1 family
uniprot
proteins
pubmed
11279525
uniprot
proteins
pubmed
12704671
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
1180
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Also present in chromatoid body (By similarity). {ECO:0000250}.
uniprot
proteins