GJC1
entrez
10052
canonical
uniprot
P36383
canonical
ensembl
ENSG00000182963
resolver
ensp
ENSP00000333193
resolver
ensp
ENSP00000466339
resolver
ensp
ENSP00000467201
resolver
ensp
ENSP00000577338
resolver
ensp
ENSP00000577339
resolver
ensp
ENSP00000577340
resolver
ensp
ENSP00000577341
resolver
ensp
ENSP00000577342
resolver
ensp
ENSP00000590168
resolver
ensp
ENSP00000590169
resolver
ensp
ENSP00000590170
resolver
ensp
ENSP00000590171
resolver
ensp
ENSP00000590172
resolver
ensp
ENSP00000634244
resolver
ensp
ENSP00000634245
resolver
enst
ENST00000330514
resolver
enst
ENST00000590758
resolver
enst
ENST00000592524
resolver
enst
ENST00000907279
resolver
enst
ENST00000907280
resolver
enst
ENST00000907281
resolver
enst
ENST00000907282
resolver
enst
ENST00000907284
resolver
enst
ENST00000920109
resolver
enst
ENST00000920110
resolver
enst
ENST00000920111
resolver
enst
ENST00000920112
resolver
enst
ENST00000920113
resolver
enst
ENST00000964185
resolver
enst
ENST00000964186
resolver
genesymbol
GJC1
resolver
genesymbol_syn
GJA7
resolver
hgnc
HGNC:4280
resolver
uniprot
B3KW68
resolver
uniprot
Q4VAY0
resolver
uniprot_entry
CXG1_HUMAN
resolver
uniprot_sec
B3KW68
resolver
uniprot_sec
Q4VAY0
resolver
amino_acid_sequence
MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWKQHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANTAQEQQYGSHEENLPADLEALQREIRMAQERLDLAVQAYSHQNNPHGPREKKAKVGSKAGSNKSTASSKSGDGKTSVWI
uniprot
proteins
function
FUNCTION: Structural component of the gap junction, a specialized intercellular structure consisting of a cluster of closely packed pairs of transmembrane channels, the connexons, that allow passage of small molecules and electrical signals between neighboring cells. Forms homotypic and heterotypic channels gated by transjunctional voltage (By similarity). Involved in intercellular innate immune signaling. Mediates translocation of 2',3'-cGAMP and 2',5'-oligoadenylates (2-5A) second messengers from virus-infected cells to macrophages and uninfected neighboring cells to propagate and amplify the antiviral immune response (PubMed:24077100, PubMed:31992625, PubMed:40010341). {ECO:0000250|UniProtKB:A4GG66, ECO:0000269|PubMed:24077100, ECO:0000269|PubMed:31992625, ECO:0000269|PubMed:40010341}.
uniprot
proteins
mass_dalton
45470
uniprot
proteins
protein_family
Connexin family
uniprot
proteins
protein_family
Gamma-type subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
19864490
uniprot
proteins
pubmed
24077100
uniprot
proteins
pubmed
31992625
uniprot
proteins
pubmed
40010341
uniprot
proteins
pubmed
7966354
uniprot
proteins
sequence_length
396
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19864490}; Multi-pass membrane protein {ECO:0000255}. Cell junction, gap junction {ECO:0000269|PubMed:19864490}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..45; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 76..95; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 176..198; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 229..248; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins