Abca8a
entrez
217258
canonical
uniprot
Q8K442
canonical
ensembl
ENSMUSG00000041828
resolver
ensp
ENSMUSP00000097860
resolver
enst
ENSMUST00000100287
resolver
genesymbol
Abca8a
resolver
genesymbol_syn
abca8a
resolver
uniprot
A2AB96
resolver
uniprot
A4PBQ7
resolver
uniprot
Q6PAV3
resolver
uniprot
Q8C0A9
resolver
uniprot
Q8R0R4
resolver
uniprot_entry
A4PBQ7_MOUSE
resolver
uniprot_entry
ABC8A_MOUSE
resolver
uniprot_sec
A2AB96
resolver
uniprot_sec
Q6PAV3
resolver
uniprot_sec
Q8C0A9
resolver
uniprot_sec
Q8R0R4
resolver
activity_regulation
ACTIVITY REGULATION: Cholesterol efflux is increased by extracellularly applied taurocholate. {ECO:0000250|UniProtKB:O94911}.
uniprot
proteins
amino_acid_sequence
MVKREINVCQQTWALLCKNLLRKKRLKRDTFLEFLYTALILLSLILFLQLHEVYDFSSLPDVDLGRIDSFNDSTFMIVYTPITPTTQRIMDRVSLVSYMTGRKILASPNEENMTELISMRFSDVVGVIFTNAYSYNLKFIKGARIPTIKEHQDHTAHCHSYGEIIYCGLSEFWRDGFVALQAAINAAIIEVTTNHSVMEEMMSLTGKYIKIDSFVGQEGTTTDCFLFFCIIRFSPLTYYISAGVTRERKKMKGLMAVMGLRDSAFWLSWGLLYGVIVFVVTLLSTTIVKLVQFVFLTGFMVIFSLFFFYGLSLISLSFLMSVLLKKSFLTDLVVFLLTVSCGSLGFTALYRYLPVSLEWLLSLLSPFAFMLGMVQLLRLDYDVNSNADPMGNPNEVIGTIFMLFFDGVFYLLLTFYFEKVLPSKSFHDKTYWHACKSHFFLIDYSFYIRTALDNETDYEFSDDSFEPVSMEFHGKEAIRIRNLTKDYIQKSKRTEALKDLTLDVYKGQITAILGHSGAGKSTLLNVLSGLCVPTKGWVTIHNNKLSEMTDLENISKLTGVCPQCNVQFDFLTVRENLRLFAKIKGIQAHEVDNEVQRVLLELDMKNTQNILVQNLSGGQKRKLTFGIAILGDPQIFLLDEPTAGLDPFSRHRVWNFLKERRADRVVLFSTQFMDEADILADRKVFISKGKLKCAGSSLFLKKKWGIGYHLSLQLSETCVHERITSLVKQHIPDSKLSAESEGKLSYILPLERTNKFPDLYRDLERSPDLGIENYGVSITTLTEVFLKLEGKSSIDQSDIGMTEDVQAGGARSPERFAEVEQLVSLLNGRCKMKGGMALWWQQLCAVTRLRFLKLKHERKSIVILILVLGIGLLHILSANIYRMVRQSDYCWELAPHMYFLTPGQQPQPPLTNLLIVNKTGAKIDDFIHSLEQQNIALEVDAFGTRNGTEDSQYNGAIILSGDEKNYNFTLACNTKRLNCFPVLVDIVSNGLLGLFAPSAHIQTDRSTFPEENDHRKFDYLAYFFLWVLLMACVPPYISMTSIDDYKNRAQFQLWISGLSPSAYWFGQALFEVPVYCALILSIFIAFYASAPPESKFTVGDLFIQILYVGGYAMSVIFMTYVISFIYRKGRKNSGLWSLCFYIVSFFSMCFMLIDYFRDISLFVLIALVPPATLGGCTLLHFENREFSEIIFEPEREYSYLFFLAPLLHFAIFVVILRCMERKFGMKTMRTDPVFRISPRSDRVFNNPEDPDGEDEDVSQERVWTANALTSADFQEKPAIIASCLRKEYKGKKKCFVLKSKKKIATRNISFCVRKGEVVGLLGHNGAGKSTSIKMITGETKPSAGQVLLKGSSTGDTPGFLGYCPQENALWLNLTVREHLEIFAAIKGMRKSDANVAIERLADALKLQDQLKSPVKTLSEGVKRKLCFVLSILGNPSVVLLDEPSTGMDPEGQQQMWQAIQATFSNTERGALLTTHYMAEAEAVCDRVAIMVSGRLRCIGSIQHLKSKFGKEYLLEMKVKTPSQVEPLNTEIMRLFPQAARQERYSSLMVYKLPREDVQPLSQAFFKLETVKQSFDLEEYSLSQSTLEQVFLELSKEQELDGFEEELDPSVKWKLLPQEEA
uniprot
proteins
ec_number
7.6.2.-
uniprot
proteins
function
FUNCTION: Mediates cholesterol and taurocholate efflux. Through the interaction with ABCA1 potentiates the cholesterol efflux to lipid-free APOA1, in turn regulates high-density lipoprotein cholesterol levels. {ECO:0000250|UniProtKB:O94911}.
uniprot
proteins
mass_dalton
184180
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCA family
uniprot
proteins
pubmed
12532264
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16445568
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28882873
uniprot
proteins
pubmed
29300488
uniprot
proteins
sequence_length
1620
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O94911}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O94911}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q8K440}. Note=Predominantly expressed on the sinusoidal plasma membrane. {ECO:0000250|UniProtKB:Q8K440}.
uniprot
proteins
transmembrane_region
TRANSMEM 30..50; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 224..244; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 263..283; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 294..314; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 328..348; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 357..377; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 397..417; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 861..881; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 979..999; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1019..1039; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1068..1088; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1105..1125; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1133..1153; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1159..1179; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1196..1216; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins