Galnt1
entrez
14423
canonical
uniprot
O08912
canonical
ensembl
ENSMUSG00000000420
resolver
ensp
ENSMUSP00000000430
resolver
ensp
ENSMUSP00000132142
resolver
ensp
ENSMUSP00000137427
resolver
ensp
ENSMUSP00000165553
resolver
enst
ENSMUST00000000430
resolver
enst
ENSMUST00000170243
resolver
enst
ENSMUST00000178605
resolver
genesymbol
Galnt1
resolver
uniprot
Q3UFE4
resolver
uniprot
Q5BKS3
resolver
uniprot
Q7TND1
resolver
uniprot_entry
GALT1_MOUSE
resolver
uniprot_entry
Q3UFE4_MOUSE
resolver
uniprot_sec
Q5BKS3
resolver
uniprot_sec
Q7TND1
resolver
amino_acid_sequence
MRKFAYCKVVLATSLVWVLLDMFLLLYFSECNKCEEKQERGLPAGDVLELVQKPHEGPGEMGKPVVIPKEDQEKMKEMFKINQFNLMASEMIALNRSLPDVRLEGCKTKVYPDNLPTTSVVIVFHNEAWSTLLRTVHSVINRSPRHMIEEIVLVDDASERDFLKRPLESYVKKLKVPVHVIRMEQRSGLIRARLKGAAVSRGQVITFLDAHCECTAGWLEPLLARIKHDRRTVVCPIIDVISDDTFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPVRTPTMAGGLFSIDRDYFQEIGTYDAGMDIWGGENLEISFRIWQCGGTLEIVTCSHVGHVFRKATPYTFPGGTGQIINKNNRRLAEVWMDEFKNFFYIISPGVTKVDYGDISSRLGLRRKLQCKPFSWYLENIYPDSQIPRHYFSLGEIRNVETNQCLDNMARKENEKVGIFNCHGMGGNQVFSYTANKEIRTDDLCLDVSKLNGPVTMLKCHHLKGNQLWEYDPVKLTLQHVNSNQCLDKATEEDSQVPSIRDCTGSRSQQWLLRNVTLPEIF
uniprot
proteins
ec_number
2.4.1.41
uniprot
proteins
function
FUNCTION: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:10037781, PubMed:9153242). Has a broad spectrum of substrates such as apomucin-, MUC5AC-, MUC1- and MUC2-derived peptides (By similarity). {ECO:0000250|UniProtKB:Q10472, ECO:0000269|PubMed:10037781, ECO:0000269|PubMed:9153242}.
uniprot
proteins
mass_dalton
64255
uniprot
proteins
mutagenesis
MUTAGEN 125; /note="H->F: No effect."; /evidence="ECO:0000269|PubMed:10037781"; MUTAGEN 125; /note="H->Q: Induces a strong decrease in activity."; /evidence="ECO:0000269|PubMed:10037781"; MUTAGEN 127; /note="E->Q: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:10037781"; MUTAGEN 150; /note="E->Q: No effect."; /evidence="ECO:0000269|PubMed:10037781"; MUTAGEN 155; /note="D->N: No effect; specificity not affected."; /evidence="ECO:0000269|PubMed:10037781"; MUTAGEN 156; /note="D->Q: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:10037781"; MUTAGEN 209; /note="D->N,A,E: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:10037781"; MUTAGEN 211; /note="H->A,D: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:10037781"; MUTAGEN 213; /note="E->Q: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:10037781"; MUTAGEN 310; /note="D->N: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:10037781"; MUTAGEN 319; /note="E->Q: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:10037781"; MUTAGEN 320; /note="N->A: No effect."; /evidence="ECO:0000269|PubMed:10037781"; MUTAGEN 322; /note="E->Q: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:10037781"; MUTAGEN 341; /note="H->A,L,V,K,R: Little or no effect."; /evidence="ECO:0000269|PubMed:10037781"; MUTAGEN 375; /note="D->A,N: Little or no effect."; /evidence="ECO:0000269|PubMed:10037781"; MUTAGEN 376; /note="E->Q: No effect."; /evidence="ECO:0000269|PubMed:10037781"; MUTAGEN 444; /note="D->H: Induces a decrease in activity."; /evidence="ECO:0000269|PubMed:10037781"; MUTAGEN 455; /note="G->V: Induces a slight decrease in activity."; /evidence="ECO:0000269|PubMed:10037781"; MUTAGEN 457; /note="F->H: Induces a slight decrease in activity."; /evidence="ECO:0000269|PubMed:10037781"; MUTAGEN 460; /note="H->K,N: Induces a slight decrease in activity."; /evidence="ECO:0000269|PubMed:10037781"; MUTAGEN 464; /note="G->A: Induces a slight decrease in activity."; /evidence="ECO:0000269|PubMed:10037781"; MUTAGEN 465..466; /note="NQ->QN: Induces a decrease in activity."; MUTAGEN 465; /note="N->A: Little or no effect. Induces a slight decrease in activity; when associated with A-466."; /evidence="ECO:0000269|PubMed:10037781"; MUTAGEN 466; /note="Q->A: Little or no effect. Induces a slight decrease in activity; when associated with A-465."; /evidence="ECO:0000269|PubMed:10037781
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:10037781, ECO:0000269|PubMed:9153242}.
uniprot
proteins
protein_family
GalNAc-T subfamily
uniprot
proteins
protein_family
Glycosyltransferase 2 family
uniprot
proteins
pubmed
10037781
uniprot
proteins
pubmed
12651884
uniprot
proteins
pubmed
15486088
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9153242
uniprot
proteins
sequence_length
559
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Polypeptide N-acetylgalactosaminyltransferase 1]: Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Polypeptide N-acetylgalactosaminyltransferase 1 soluble form]: Secreted {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..28; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins