Fas
entrez
14102
canonical
uniprot
P25446
canonical
ensembl
ENSMUSG00000024778
resolver
ensp
ENSMUSP00000025691
resolver
ensp
ENSMUSP00000108091
resolver
enst
ENSMUST00000025691
resolver
enst
ENSMUST00000112472
resolver
genesymbol
Fas
resolver
genesymbol_syn
Apt1
resolver
genesymbol_syn
Tnfrsf6
resolver
uniprot
A0ACM8Q274
resolver
uniprot
D3Z6E5
resolver
uniprot
Q6GT31
resolver
uniprot
Q8C350
resolver
uniprot
Q9DCQ1
resolver
uniprot_entry
A0ACM8Q274_MOUSE
resolver
uniprot_entry
Q8C350_MOUSE
resolver
uniprot_entry
TNR6_MOUSE
resolver
uniprot_sec
D3Z6E5
resolver
uniprot_sec
Q6GT31
resolver
uniprot_sec
Q9DCQ1
resolver
amino_acid_sequence
MLWIWAVLPLVLAGSQLRVHTQGTNSISESLKLRRRVRETDKNCSEGLYQGGPFCCQPCQPGKKKVEDCKMNGGTPTCAPCTEGKEYMDKNHYADKCRRCTLCDEEHGLEVETNCTLTQNTKCKCKPDFYCDSPGCEHCVRCASCEHGTLEPCTATSNTNCRKQSPRNRLWLLTILVLLIPLVFIYRKYRKRKCWKRRQDDPESRTSSRETIPMNASNLSLSKYIPRIAEDMTIQEAKKFARENNIKEGKIDEIMHDSIQDTAEQKVQLLLCWYQSHGKSDAYQDLIKGLKKAECRRTLDKFQDMVQKDLGKSTPDTGNENEGQCLE
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Fas are the cause of the lymphoproliferation phenotype (lpr) (PubMed:1372394). Lpr mice show lymphadenopathy and autoantibody production (PubMed:1372394). {ECO:0000269|PubMed:1372394}.
uniprot
proteins
function
FUNCTION: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity). {ECO:0000250|UniProtKB:P25445}.
uniprot
proteins
mass_dalton
37437
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. Palmitoylation by ZDHHC7 prevents the lysosomal degradation of FAS regulating its expression at the plasma membrane. {ECO:0000250|UniProtKB:P25445}.
uniprot
proteins
pubmed
11034606
uniprot
proteins
pubmed
1371136
uniprot
proteins
pubmed
1372394
uniprot
proteins
pubmed
15383280
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17545588
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23785138
uniprot
proteins
pubmed
7680478
uniprot
proteins
pubmed
9215629
uniprot
proteins
sequence_length
327
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P51867}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P51867}. Membrane raft {ECO:0000250|UniProtKB:P25445}.
uniprot
proteins
transmembrane_region
TRANSMEM 170..186; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins