TCEA2
entrez
6919
canonical
uniprot
Q15560
canonical
ensembl
ENSG00000171703
resolver
ensp
ENSP00000339432
resolver
ensp
ENSP00000343515
resolver
ensp
ENSP00000354552
resolver
ensp
ENSP00000407085
resolver
ensp
ENSP00000416026
resolver
genesymbol
TCEA2
resolver
hgnc
HGNC:11614
resolver
uniprot
B3KNM1
resolver
uniprot
Q6IB64
resolver
uniprot
Q8TD37
resolver
uniprot
Q8TD38
resolver
uniprot_entry
Q6IB64_HUMAN
resolver
uniprot_entry
TCEA2_HUMAN
resolver
uniprot_sec
B3KNM1
resolver
uniprot_sec
Q8TD37
resolver
uniprot_sec
Q8TD38
resolver
amino_acid_sequence
MMGKEEEIARIARRLDKMVTKKSAEGAMDLLRELKAMPITLHLLQSTRVGMSVNALRKQSSDEEVIALAKSLIKSWKKLLDASDAKARERGRGMPLPTSSRDASEAPDPSRKRPELPRAPSTPRITTFPPVPVTCDAVRNKCREMLTAALQTDHDHVAIGADCERLSAQIEECIFRDVGNTDMKYKNRVRSRISNLKDAKNPDLRRNVLCGAITPQQIAVMTSEEMASDELKEIRKAMTKEAIREHQMARTGGTQTDLFTCGKCRKKNCTYTQVQTRSSDEPMTTFVVCNECGNRWKFC
uniprot
proteins
function
FUNCTION: Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus. {ECO:0000269|PubMed:12034815, ECO:0000269|PubMed:41062692}.
uniprot
proteins
mass_dalton
33601
uniprot
proteins
mutagenesis
MUTAGEN 184; /note="K->R: Complete loss of KCTD10-mediated ubiquitination. Stronger RNA polymerase II retention."; /evidence="ECO:0000269|PubMed:41062692
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the BCR(BACURD3) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD10/BACURD3 and RBX1; leading to proteasomal degradation and RNAP complex remodeling. {ECO:0000269|PubMed:41062692}.
uniprot
proteins
protein_family
TFS-II family
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12034815
uniprot
proteins
pubmed
12943681
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18655026
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
41062692
uniprot
proteins
pubmed
8566795
uniprot
proteins
pubmed
9441762
uniprot
proteins
sequence_length
299
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins