Las1l
entrez
76130
canonical
uniprot
A2BE28
canonical
ensembl
ENSMUSG00000057421
resolver
ensp
ENSMUSP00000078901
resolver
ensp
ENSMUSP00000109495
resolver
ensp
ENSMUSP00000277363
resolver
ensp
ENSMUSP00000330388
resolver
genesymbol
Las1l
resolver
uniprot
A2BE30
resolver
uniprot
Q6KAR5
resolver
uniprot
Q8C742
resolver
uniprot_entry
LAS1L_MOUSE
resolver
uniprot_sec
A2BE30
resolver
uniprot_sec
Q6KAR5
resolver
uniprot_sec
Q8C742
resolver
amino_acid_sequence
MDRVWRAWDGQSFKENQPESPSARGIVVSWLSRAEWEQVTVYLFCDDHKLQQYALNRITVWRSRLGNELPLAVASTADLVRCKLIDAAGTLGTDELRLLYGMALVRFVNLISERKTKCSNLPLKYLAQEVNIPDWIVELRHNLTHKKMPHINECRRGCYFVLNWLQKTYWSRQLEGSLKETWELDEDQLDAEDPEEEEREIIADDVLEEIPEPQDDDKDEELAVEDDANTKGNEEVASHPEPSSRHKELYEKARELLVSYEEEQFKVLEKHRHLLQAIKVWNNLSPRVQCILEELKSISWENRDAVLDAFLDDGFLIPTFEQLAALQIEYEDGQTEVQKGEVTEPNSHKNIDLNEVLVPKPFSQFWQPLLRGLHSQTFTQALLERMFSELSTVGSTGIRPTYILRWTVELIVANTKTGRNARRFSASQWEARKSWRLFNCSATLDWPQVIESCLGSPCWASPQLLQVVFKAMGQVLPDEEQEKLLRVCSIYTQNGENGLAKAIEGSSSSSTGKAPYTLDTLHEDLQPPGTNCESEESIQQKEQGNLKDVKQEEKKENEEEEKEEEEMEEEEEEEEEEKEEEEEEQEQEEHQEEEQEEEEEEENQKVFQDQMEADVEESDDVEEEEEVDDEEEDEDDDYDDDEEEDRMEVGAFSLAQGSSVFENTRTTSRKREALQGSAWQVSSEDVRWGTFPLGRLPGQTEDPAELMLDNYDTMYLLDQPVIEHRLEPQKSKSSTLSLCCGGSNTNSSSSSSSGNMEGLLWNQGQMHGLKAGLQLF
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: Required for the synthesis of the 60S ribosomal subunit and maturation of the 28S rRNA (By similarity). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes (PubMed:22872859). Required for the efficient pre-rRNA processing at both ends of internal transcribed spacer 2 (ITS2) (By similarity). {ECO:0000250|UniProtKB:Q9Y4W2, ECO:0000269|PubMed:22872859}.
uniprot
proteins
mass_dalton
89414
uniprot
proteins
protein_family
LAS1 family
uniprot
proteins
pubmed
15449545
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22872859
uniprot
proteins
sequence_length
776
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9Y4W2}. Nucleus, nucleoplasm {ECO:0000269|PubMed:22872859}. Cytoplasm {ECO:0000269|PubMed:22872859}. Note=Localizes mainly to the granular component, the region implicated in the later steps of rRNA processing and subunit assembly and export (By similarity). Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions. {ECO:0000250|UniProtKB:Q9Y4W2, ECO:0000269|PubMed:22872859}.
uniprot
proteins