Map2k3
entrez
26397
canonical
uniprot
O09110
canonical
ensembl
ENSMUSG00000018932
resolver
ensp
ENSMUSP00000019076
resolver
genesymbol
Map2k3
resolver
genesymbol_syn
Mkk3
resolver
genesymbol_syn
Prkmk3
resolver
uniprot
P97293
resolver
uniprot
Q5SWN9
resolver
uniprot
Q91VX1
resolver
uniprot_entry
MP2K3_MOUSE
resolver
uniprot_entry
Q5SWN9_MOUSE
resolver
uniprot_sec
P97293
resolver
uniprot_sec
Q91VX1
resolver
activity_regulation
ACTIVITY REGULATION: Activated by dual phosphorylation on Ser-218 and Thr-222. {ECO:0000250|UniProtKB:P46734}.
uniprot
proteins
amino_acid_sequence
MESPAASPPASLPQTKGKSKRKKDLRISCVSKPPVSNPTPPRNLDSRTFITIGDRNFEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNTQEQKRLLMDLDINMRTVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLEKNMKIPEDILGEIAVSIVRALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPERINPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPADQFSPEFVDFTSQCLRKNPAERMSYLELMEHPFFTLHKTKKTDIAAFVKEILGEDS
uniprot
proteins
ec_number
2.7.12.2
uniprot
proteins
function
FUNCTION: Dual specificity kinase. Is activated by cytokines and environmental stress in vivo. Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinase p38. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. {ECO:0000250|UniProtKB:P46734}.
uniprot
proteins
mass_dalton
39296
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. Phosphorylation on Ser-218 and Thr-222 by MAP kinase kinase kinases positively regulates the kinase activity. Phosphorylated by TAOK2. {ECO:0000250|UniProtKB:P46734}.
uniprot
proteins
protein_family
MAP kinase kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
pubmed
14634666
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8900184
uniprot
proteins
sequence_length
347
uniprot
proteins