B0F2B4
uniprot
B0F2B4
canonical
amino_acid_sequence
MPAPVPALLCLALALASAQPSPPPPPPFPVVATNYGKLRGVRAALPGDVLGPVTQFLGVPYAAPPTGERRFQPPEPPSSWAGVRDATRFAPVCPQHLDERALLRDCLPAWFAANLDAIAAYVQDQSEDCLYLNLYVPGGANGKKMADDVTGNDHGDDQDSRDPGVGGAAAAAARKPVMVYIHGGSYMEGTANIVDGSVLASYGDVIVVTVNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWVEENAGAFGGDPDRVTVFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPARYARALGERVGCATPDPGSPPGSPPGWDSASLVSCLRGKAAGELARARVTPATYHVAFGPTVDGDVIPDDPQILMEQGEFLNYDIMLGVNQGEGARFVDGLGGGHDGGYGGYGGGYGGGVEDDEVQDGGPDGAAGGVSAGEFDLAVSGFINDLYGRPEGRGDALRETVKFMYTDWADRDSPEARRKTLVALFTDHQWVAPAVATADLHARYGSPTYFYAFYHRCHGGGGGGGGVDGVAGGVAGGVGGEEARPAWADAAHGDEVPYVFGVHMAGPGDVFGCNFSRNDVMLSAVVMTYWTNFAKTGDPNQPVAQDTRFVHTRPNRFEEVAWAKYDPRGQLYLHIGLRPRVRDHYRAAKVAFWLELVPHLHGLAADPGAYLSAAATRAAPSGDPDRDPGGGGGGRRRPRPATRRPAVMTSSSMASGSGMTSSSGSGMTSSSGSSASAVLIETRRDYSTELSVTIAVGASLLFLNVLAFAALYYKKDKRRHETHRRPPPPRPPQAPPSAAAADRNPRPDPGPAGRRGGECGAVVTAMAAEASAGGLGHDGVGGVGVGGVIGGVAGLRLACPPDYALTLRRSPDDVPRAGAGPGTMTLIPGALGGGGGGAVHGFNTFGSGVGVAGVAGVATSQAGPGLPHGHSTTRV
uniprot
proteins
function
FUNCTION: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in the formation or maintenance of synaptic junctions via its interactions (via the extracellular domains) with neurexin family members. Plays a role in synaptic signal transmission. {ECO:0000269|PubMed:18434543, ECO:0000269|PubMed:21282647, ECO:0000269|PubMed:30100184}.
uniprot
proteins
mass_dalton
97348
uniprot
proteins
mutagenesis
MUTAGEN 648..652; /note="RPRVR->APAVA: Reduced presynaptic differentiation."; /evidence="ECO:0000269|PubMed:30100184
uniprot
proteins
post_translational_modification
PTM: N-glycosylated, contains high-mannose, hybrid, complex and sialylated N-glycans. N-glycosylation is essential for localization to synapses, dendrites, and the cell membrane, and enhances its availability for trans-synaptic adhesion. O-glycosylated. {ECO:0000250|UniProtKB:Q8N0W4}.
uniprot
proteins
protein_family
Type-B carboxylesterase/lipase family
uniprot
proteins
pubmed
18227507
uniprot
proteins
pubmed
18434543
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21282647
uniprot
proteins
pubmed
30100184
uniprot
proteins
sequence_length
945
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21282647}; Single-pass type I membrane protein {ECO:0000255}. Postsynaptic cell membrane {ECO:0000269|PubMed:18227507}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, dendritic spine {ECO:0000269|PubMed:18434543}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8N0W4}. Synapse {ECO:0000269|PubMed:21282647}. Note=Detected at glycinergic postsynapses in retina. Localizes to dendritic membrane (By similarity). {ECO:0000250|UniProtKB:Q8N0W4, ECO:0000269|PubMed:21282647}.
uniprot
proteins
transmembrane_region
TRANSMEM 762..782; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins