SKIC8
entrez
80349
canonical
uniprot
Q9GZS3
canonical
ensembl
ENSG00000140395
resolver
ensp
ENSP00000267973
resolver
ensp
ENSP00000453024
resolver
ensp
ENSP00000453801
resolver
ensp
ENSP00000453902
resolver
ensp
ENSP00000580533
resolver
ensp
ENSP00000595936
resolver
ensp
ENSP00000629602
resolver
ensp
ENSP00000629603
resolver
ensp
ENSP00000656946
resolver
enst
ENST00000267973
resolver
enst
ENST00000558311
resolver
enst
ENST00000558459
resolver
enst
ENST00000910474
resolver
enst
ENST00000925877
resolver
enst
ENST00000959543
resolver
enst
ENST00000959544
resolver
genesymbol
SKIC8
resolver
genesymbol_syn
WDR61
resolver
hgnc
HGNC:30300
resolver
uniprot
D3DW84
resolver
uniprot
H0YL19
resolver
uniprot
Q6IA22
resolver
uniprot
Q7Z4X4
resolver
uniprot_entry
H0YL19_HUMAN
resolver
uniprot_entry
SKI8_HUMAN
resolver
uniprot_sec
D3DW84
resolver
uniprot_sec
Q6IA22
resolver
uniprot_sec
Q7Z4X4
resolver
amino_acid_sequence
MTNQYGILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYDCPI
uniprot
proteins
function
FUNCTION: Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency (PubMed:16307923, PubMed:19952111, PubMed:20178742). PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1 (PubMed:16307923, PubMed:19952111, PubMed:20178742). PAF1C is required for transcription of Hox and Wnt target genes (PubMed:16307923, PubMed:19952111, PubMed:20178742). PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL (PubMed:16307923, PubMed:19952111, PubMed:20178742). PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3) (PubMed:16307923, PubMed:19952111, PubMed:20178742). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription (PubMed:16307923, PubMed:19952111, PubMed:20178742). PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors (PubMed:16307923, PubMed:19952111, PubMed:20178742). In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription (PubMed:16307923, PubMed:19952111, PubMed:20178742). Required for mono- and trimethylation on histone H3 'Lys-4' (H3K4me3), dimethylation on histone H3 'Lys-79' (H3K4me3). Required for Hox gene transcription (PubMed:16307923, PubMed:19952111, PubMed:20178742). Also acts as a component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways (PubMed:16024656, PubMed:32006463, PubMed:35120588). The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation (PubMed:32006463, PubMed:35120588). SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling (PubMed:32006463). {ECO:0000269|PubMed:16024656, ECO:0000269|PubMed:16307923, ECO:0000269|PubMed:19952111, ECO:0000269|PubMed:20178742, ECO:0000269|PubMed:32006463, ECO:0000269|PubMed:35120588}.
uniprot
proteins
mass_dalton
33581
uniprot
proteins
protein_family
SKI8 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16024656
uniprot
proteins
pubmed
16307923
uniprot
proteins
pubmed
18445686
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19952111
uniprot
proteins
pubmed
20178742
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21468892
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
32006463
uniprot
proteins
pubmed
35120588
uniprot
proteins
sequence_length
305
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16024656, ECO:0000269|PubMed:18445686}. Cytoplasm {ECO:0000269|PubMed:18445686, ECO:0000305|PubMed:16024656}.
uniprot
proteins