BRDT
entrez
676
canonical
uniprot
Q58F21
canonical
ensembl
ENSG00000137948
resolver
ensp
ENSP00000354568
resolver
ensp
ENSP00000359416
resolver
ensp
ENSP00000378038
resolver
ensp
ENSP00000384051
resolver
ensp
ENSP00000387822
resolver
genesymbol
BRDT
resolver
hgnc
HGNC:1105
resolver
uniprot
A6NF68
resolver
uniprot
B7Z811
resolver
uniprot
B7Z890
resolver
uniprot
B7ZAX7
resolver
uniprot
D3DT32
resolver
uniprot
O14789
resolver
uniprot
Q05DQ4
resolver
uniprot
Q6P5T1
resolver
uniprot
Q7Z4A6
resolver
uniprot
Q8IWI6
resolver
uniprot_entry
BRDT_HUMAN
resolver
uniprot_sec
A6NF68
resolver
uniprot_sec
B7Z811
resolver
uniprot_sec
B7Z890
resolver
uniprot_sec
B7ZAX7
resolver
uniprot_sec
D3DT32
resolver
uniprot_sec
O14789
resolver
uniprot_sec
Q05DQ4
resolver
uniprot_sec
Q6P5T1
resolver
uniprot_sec
Q7Z4A6
resolver
uniprot_sec
Q8IWI6
resolver
amino_acid_sequence
MSLPSRQTAIIVNPPPPEYINTKKNGRLTNQLQYLQKVVLKDLWKHSFSWPFQRPVDAVKLQLPDYYTIIKNPMDLNTIKKRLENKYYAKASECIEDFNTMFSNCYLYNKPGDDIVLMAQALEKLFMQKLSQMPQEEQVVGVKERIKKGTQQNIAVSSAKEKSSPSATEKVFKQQEIPSVFPKTSISPLNVVQGASVNSSSQTAAQVTKGVKRKADTTTPATSAVKASSEFSPTFTEKSVALPPIKENMPKNVLPDSQQQYNVVKTVKVTEQLRHCSEILKEMLAKKHFSYAWPFYNPVDVNALGLHNYYDVVKNPMDLGTIKEKMDNQEYKDAYKFAADVRLMFMNCYKYNPPDHEVVTMARMLQDVFETHFSKIPIEPVESMPLCYIKTDITETTGRENTNEASSEGNSSDDSEDERVKRLAKLQEQLKAVHQQLQVLSQVPFRKLNKKKEKSKKEKKKEKVNNSNENPRKMCEQMRLKEKSKRNQPKKRKQQFIGLKSEDEDNAKPMNYDEKRQLSLNINKLPGDKLGRVVHIIQSREPSLSNSNPDEIEIDFETLKASTLRELEKYVSACLRKRPLKPPAKKIMMSKEELHSQKKQELEKRLLDVNNQLNSRKRQTKSDKTQPSKAVENVSRLSESSSSSSSSSESESSSSDLSSSDSSDSESEMFPKFTEVKPNDSPSKENVKKMKNECIPPEGRTGVTQIGYCVQDTTSANTTLVHQTTPSHVMPPNHHQLAFNYQELEHLQTVKNISPLQILPPSGDSEQLSNGITVMHPSGDSDTTMLESECQAPVQKDIKIKNADSWKSLGKPVKPSGVMKSSDELFNQFRKAAIEKEVKARTQELIRKHLEQNTKELKASQENQRDLGNGLTVESFSNKIQNKCSGEEQKEHQQSSEAQDKSKLWLLKDRDLARQKEQERRRREAMVGTIDMTLQSDIMTMFENNFD
uniprot
proteins
disease_involvement
DISEASE: Spermatogenic failure 21 (SPGF21) [MIM:617644]: An infertility disorder caused by spermatogenesis defects and characterized by acephalic spermatozoa in the semen of affected individuals. SPGF21 inheritance is autosomal recessive. {ECO:0000269|PubMed:28199965}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis (PubMed:22464331, PubMed:22901802). Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time (PubMed:22901802). In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA (PubMed:22901802). Also recognizes and binds a subset of butyrylated histones: able to bind histone H4 butyrylated at 'Lys-8' (H4K8ac), while it is not able to bind H4 butyrylated at 'Lys-5' (H4K5ac) (By similarity). Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids (By similarity). Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin. {ECO:0000250|UniProtKB:Q91Y44, ECO:0000269|PubMed:15647849, ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:22901802, ECO:0000269|PubMed:9367677}.
uniprot
proteins
mass_dalton
107954
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated in a SPOP-dependent manner, leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q91Y44}.
uniprot
proteins
protein_family
BET family
uniprot
proteins
pubmed
10704737
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15647849
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
20538714
uniprot
proteins
pubmed
22464331
uniprot
proteins
pubmed
22901802
uniprot
proteins
pubmed
22971749
uniprot
proteins
pubmed
25593309
uniprot
proteins
pubmed
28199965
uniprot
proteins
pubmed
9367677
uniprot
proteins
sequence_length
947
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20538714, ECO:0000269|PubMed:22901802, ECO:0000269|PubMed:22971749, ECO:0000269|PubMed:25593309}. Note=Detected on chromatin. {ECO:0000250|UniProtKB:Q91Y44}.
uniprot
proteins