HOMER1
entrez
9456
canonical
uniprot
Q86YM7
canonical
ensembl
ENSG00000152413
resolver
ensp
ENSP00000282260
resolver
ensp
ENSP00000334382
resolver
ensp
ENSP00000426651
resolver
genesymbol
HOMER1
resolver
genesymbol_syn
SYN47
resolver
hgnc
HGNC:17512
resolver
uniprot
B2R688
resolver
uniprot
O96003
resolver
uniprot
Q5U5K4
resolver
uniprot
Q86YM5
resolver
uniprot_entry
HOME1_HUMAN
resolver
uniprot_entry
Q5U5K4_HUMAN
resolver
uniprot_sec
B2R688
resolver
uniprot_sec
O96003
resolver
uniprot_sec
Q86YM5
resolver
amino_acid_sequence
MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINSTITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEKMELTSTPSQESAGGDLQSPLTPESINGTDDERTPDVTQNSEPRAEPTQNALPFSHSSAISKHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQANAVHTHKTELNQTIQELEETLKLKEEEIERLKQEIDNARELQEQRDSLTQKLQEVEIRNKDLEGQLSDLEQRLEKSQNEQEAFRNNLKTLLEILDGKIFELTELRDNLAKLLECS
uniprot
proteins
function
FUNCTION: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development. Forms a high-order complex with SHANK1, which in turn is necessary for the structural and functional integrity of dendritic spines (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901). {ECO:0000250|UniProtKB:Q9Z214, ECO:0000269|PubMed:18218901}.
uniprot
proteins
mass_dalton
40277
uniprot
proteins
protein_family
Homer family
uniprot
proteins
pubmed
10464340
uniprot
proteins
pubmed
10851183
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18218901
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25489052
uniprot
proteins
pubmed
9808458
uniprot
proteins
sequence_length
354
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Postsynaptic density {ECO:0000250}. Synapse {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q9Z214}. Note=Isoform 1 inhibits surface expression of GRM5 causing it to be retained in the endoplasmic reticulum. {ECO:0000250}.
uniprot
proteins