Cops3
entrez
287367
canonical
uniprot
Q68FW9
canonical
ensembl
ENSRNOG00000053943
resolver
ensembl
ENSRNOG00055026801
resolver
ensembl
ENSRNOG00060030239
resolver
ensembl
ENSRNOG00065007921
resolver
ensp
ENSRNOP00000069208
resolver
ensp
ENSRNOP00055038091
resolver
ensp
ENSRNOP00060043831
resolver
ensp
ENSRNOP00065009174
resolver
enst
ENSRNOT00000091471
resolver
enst
ENSRNOT00055046438
resolver
enst
ENSRNOT00060052722
resolver
enst
ENSRNOT00065012476
resolver
genesymbol
Cops3
resolver
genesymbol_syn
Csn3
resolver
uniprot_entry
CSN3_RAT
resolver
amino_acid_sequence
MASALEQFVNSVRQLSAQGQMTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFVKFSMPSVPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGIGILKQAIDKMQMNTNQLTSVHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKHFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLILLGKVQQLPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPSELRNLVNKHSETFTRDNNMGLVKQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSFHDNPEKYNNPAMLHNIDQEMLKCIELDERLKAMDQEITVNPQFVQKSMGSQEDDSGNKPSSYS
uniprot
proteins
function
FUNCTION: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases (By similarity). CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). Essential to maintain the survival of epiblast cells and thus the development of the postimplantation embryo (By similarity). Mediates the interaction between the desmosome and COP9 signalosome complex (CSN) protein complex (By similarity). As a result of this interaction, promotes keratinocyte differentiation via deneddylation of EGFR resulting in a reduction in EGFR protein stabilization and translocation away from the cell membrane (By similarity). {ECO:0000250|UniProtKB:O88543, ECO:0000250|UniProtKB:Q9UNS2}.
uniprot
proteins
mass_dalton
47859
uniprot
proteins
protein_family
CSN3 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
423
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UNS2}. Nucleus {ECO:0000250|UniProtKB:Q9UNS2}. Cell junction {ECO:0000250|UniProtKB:Q9UNS2}.
uniprot
proteins