Nanog
entrez
71950
canonical
uniprot
Q80Z64
canonical
ensembl
ENSMUSG00000012396
resolver
ensp
ENSMUSP00000012540
resolver
ensp
ENSMUSP00000108199
resolver
ensp
ENSMUSP00000108200
resolver
ensp
ENSMUSP00000331657
resolver
genesymbol
Nanog
resolver
genesymbol_syn
Ecat4
resolver
genesymbol_syn
Enk
resolver
uniprot
A2RS90
resolver
uniprot
B7ZN41
resolver
uniprot
Q6SMR1
resolver
uniprot
Q7TN85
resolver
uniprot_entry
A2RS90_MOUSE
resolver
uniprot_entry
B7ZN41_MOUSE
resolver
uniprot_entry
NANOG_MOUSE
resolver
uniprot_sec
Q6SMR1
resolver
uniprot_sec
Q7TN85
resolver
amino_acid_sequence
MSVGLPGPHSLPSSEEASNSGNASSMPAVFHPENYSCLQGSATEMLCTEAASPRPSSEDLPLQGSPDSSTSPKQKLSSPEADKGPEEEENKVLARKQKMRTVFSQAQLCALKDRFQKQKYLSLQQMQELSSILNLSYKQVKTWFQNQRMKCKRWQKNQWLKTSNGLIQKGSAPVEYPSIHCSYPQGYLVNASGSLSMWGSQTWTNPTWSSQTWTNPTWNNQTWTNPTWSSQAWTAQSWNGQPWNAAPLHNFGEDFLQPYVQLQQNFSASDLEVNLEATRESHAHFSTPQALELFLNYSVTPPGEI
uniprot
proteins
function
FUNCTION: Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal (PubMed:25825768). Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter (By similarity). Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation. {ECO:0000250|UniProtKB:Q9H9S0, ECO:0000269|PubMed:12787504, ECO:0000269|PubMed:12787505, ECO:0000269|PubMed:14728807, ECO:0000269|PubMed:15502159, ECO:0000269|PubMed:16518401, ECO:0000269|PubMed:16791199, ECO:0000269|PubMed:16801560, ECO:0000269|PubMed:21915945, ECO:0000269|PubMed:22988117, ECO:0000269|PubMed:25825768}.
uniprot
proteins
mass_dalton
34240
uniprot
proteins
mutagenesis
MUTAGEN 101; /note="T->A: Decreased protein expression. Decreased embryonic stem cell self-renewal."; /evidence="ECO:0000269|PubMed:25825768"; MUTAGEN 103; /note="F->A: Decreased protein expression and stability. Decreased embryonic stem cell self-renewal."; /evidence="ECO:0000269|PubMed:25825768"; MUTAGEN 112; /note="K->E: Increases affinity for DNA and protein stability; when associated with R-147."; /evidence="ECO:0000269|PubMed:18177668"; MUTAGEN 120; /note="Y->A: Decreased protein expression and stability. Decreased embryonic stem cell self-renewal."; /evidence="ECO:0000269|PubMed:25825768"; MUTAGEN 123; /note="L->A: Increased protein expression and stability."; /evidence="ECO:0000269|PubMed:25825768"; MUTAGEN 125; /note="Q->A: Decreased protein expression. No effect on protein stability."; /evidence="ECO:0000269|PubMed:25825768"; MUTAGEN 126; /note="M->A: No effect on protein stability."; /evidence="ECO:0000269|PubMed:25825768"; MUTAGEN 126; /note="M->R: Increases affinity for DNA; when associated with E-137."; /evidence="ECO:0000269|PubMed:18177668"; MUTAGEN 137; /note="Y->A: Increased protein expression. Decreased protein stability."; /evidence="ECO:0000269|PubMed:25825768"; MUTAGEN 137; /note="Y->E: Increases affinity for DNA; when associated with R-126."; /evidence="ECO:0000269|PubMed:18177668"; MUTAGEN 138; /note="K->A: Decreased protein expression and stability. Decreased embryonic stem cell self-renewal."; /evidence="ECO:0000269|PubMed:25825768"; MUTAGEN 138; /note="K->E: Reduced affinity for DNA."; /evidence="ECO:0000269|PubMed:18177668"; MUTAGEN 141; /note="K->A: Decreased protein stability."; /evidence="ECO:0000269|PubMed:25825768"; MUTAGEN 142; /note="T->A: Decreased protein expression and stability. Decreased embryonic stem cell self-renewal."; /evidence="ECO:0000269|PubMed:25825768"; MUTAGEN 142; /note="T->I: Slightly reduced affinity for DNA."; /evidence="ECO:0000269|PubMed:18177668"; MUTAGEN 145; /note="Q->A: Increased protein expression. No effect on protein stability."; /evidence="ECO:0000269|PubMed:25825768"; MUTAGEN 146; /note="N->A: No effect on protein stability. Decreased embryonic stem cell self-renewal."; /evidence="ECO:0000269|PubMed:25825768"; MUTAGEN 146; /note="N->E: Strongly reduced affinity for DNA."; /evidence="ECO:0000269|PubMed:18177668"; MUTAGEN 147; /note="Q->R: Increases affinity for DNA and protein stability; when associated with E-112."; /evidence="ECO:0000269|PubMed:18177668"; MUTAGEN 148; /note="R->A: Decreased protein stability. Decreased embryonic stem cell self-renewal."; /evidence="ECO:0000269|PubMed:25825768"; MUTAGEN 149; /note="M->A: Increased protein expression. No effect on protein stability."; /evidence="ECO:0000269|PubMed:25825768"; MUTAGEN 152; /note="K->A: Decreased protein expression and stability."; /evidence="ECO:0000269|PubMed:25825768
uniprot
proteins
protein_family
Nanog homeobox family
uniprot
proteins
pubmed
12609610
uniprot
proteins
pubmed
12787504
uniprot
proteins
pubmed
12787505
uniprot
proteins
pubmed
14728807
uniprot
proteins
pubmed
15108323
uniprot
proteins
pubmed
15502159
uniprot
proteins
pubmed
15582778
uniprot
proteins
pubmed
15619621
uniprot
proteins
pubmed
15939376
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16518401
uniprot
proteins
pubmed
16790525
uniprot
proteins
pubmed
16791199
uniprot
proteins
pubmed
16801560
uniprot
proteins
pubmed
16840789
uniprot
proteins
pubmed
18177668
uniprot
proteins
pubmed
18957414
uniprot
proteins
pubmed
19483677
uniprot
proteins
pubmed
21915945
uniprot
proteins
pubmed
22988117
uniprot
proteins
pubmed
25825768
uniprot
proteins
sequence_length
305
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:15582778}.
uniprot
proteins