TIMP1
entrez
7076
canonical
uniprot
P01033
canonical
ensembl
ENSG00000102265
resolver
ensp
ENSP00000218388
resolver
ensp
ENSP00000621244
resolver
ensp
ENSP00000621245
resolver
enst
ENST00000218388
resolver
enst
ENST00000951185
resolver
enst
ENST00000951186
resolver
genesymbol
TIMP1
resolver
genesymbol_syn
CLGI
resolver
genesymbol_syn
TIMP
resolver
hgnc
HGNC:11820
resolver
uniprot
Q14252
resolver
uniprot
Q6FGX5
resolver
uniprot
Q9UCU1
resolver
uniprot_entry
Q6FGX5_HUMAN
resolver
uniprot_entry
TIMP1_HUMAN
resolver
uniprot_sec
Q14252
resolver
uniprot_sec
Q9UCU1
resolver
amino_acid_sequence
MAPFEPLASGILLLLWLIAPSRACTCVPPHPQTAFCNSDLVIRAKFVGTPEVNQTTLYQRYEIKMTKMYKGFQALGDAADIRFVYTPAMESVCGYFHRSHNRSEEFLIAGKLQDGLLHITTCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCLWTDQLLQGSEKGFQSRHLACLPREPGLCTWQSLRSQIA
uniprot
proteins
function
FUNCTION: Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Mediates erythropoiesis in vitro; but, unlike IL3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. {ECO:0000269|PubMed:1420137, ECO:0000269|PubMed:16917503, ECO:0000269|PubMed:17050530, ECO:0000269|PubMed:1730286, ECO:0000269|PubMed:20545310, ECO:0000269|PubMed:22427646, ECO:0000269|PubMed:24635319, ECO:0000269|PubMed:3839290, ECO:0000269|PubMed:3903517, ECO:0000269|PubMed:8541540, ECO:0000269|PubMed:8576151, ECO:0000269|PubMed:9065415}.
uniprot
proteins
mass_dalton
23171
uniprot
proteins
mutagenesis
MUTAGEN 25; /note="T->E,G,K,Q,R: Reduced interaction with metalloproteinase."; /evidence="ECO:0000269|PubMed:17050530"; MUTAGEN 25; /note="T->V: Normal interaction with metalloproteinase."; /evidence="ECO:0000269|PubMed:17050530"; MUTAGEN 30; /note="H->A: Nearly abolishes metalloproteinase inhibition."; /evidence="ECO:0000269|PubMed:8541540"; MUTAGEN 32; /note="Q->A: Nearly abolishes metalloproteinase inhibition."; /evidence="ECO:0000269|PubMed:8541540"; MUTAGEN 121; /note="T->L: Decreases protein flexibility and increases affinity for MMP14."; /evidence="ECO:0000269|PubMed:20545310
uniprot
proteins
post_translational_modification
PTM: The activity of TIMP1 is dependent on the presence of disulfide bonds. {ECO:0000269|PubMed:10623524, ECO:0000269|PubMed:20545310, ECO:0000269|PubMed:2163605, ECO:0000269|PubMed:22427646, ECO:0000269|PubMed:3010309}.; PTM: N-glycosylated. {ECO:0000269|PubMed:16263699, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:16740002, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:3010309, ECO:0000269|PubMed:3839290, ECO:0000269|PubMed:3903517}.
uniprot
proteins
protein_family
Protease inhibitor I35 (TIMP) family
uniprot
proteins
pubmed
10623524
uniprot
proteins
pubmed
12834347
uniprot
proteins
pubmed
1420137
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16263699
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
1653055
uniprot
proteins
pubmed
16740002
uniprot
proteins
pubmed
16917503
uniprot
proteins
pubmed
17050530
uniprot
proteins
pubmed
1730286
uniprot
proteins
pubmed
19139490
uniprot
proteins
pubmed
20545310
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2163605
uniprot
proteins
pubmed
2171551
uniprot
proteins
pubmed
22427646
uniprot
proteins
pubmed
22905912
uniprot
proteins
pubmed
23522389
uniprot
proteins
pubmed
23982756
uniprot
proteins
pubmed
24635319
uniprot
proteins
pubmed
26091039
uniprot
proteins
pubmed
3010309
uniprot
proteins
pubmed
3839290
uniprot
proteins
pubmed
3903517
uniprot
proteins
pubmed
7507419
uniprot
proteins
pubmed
8541540
uniprot
proteins
pubmed
8576151
uniprot
proteins
pubmed
9065415
uniprot
proteins
pubmed
9286280
uniprot
proteins
pubmed
9288970
uniprot
proteins
sequence_length
207
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1730286, ECO:0000269|PubMed:24635319, ECO:0000269|PubMed:3010309, ECO:0000269|PubMed:3839290, ECO:0000269|PubMed:3903517, ECO:0000269|PubMed:8541540}.
uniprot
proteins