Fis1
entrez
288584
canonical
uniprot
P84817
canonical
ensembl
ENSRNOG00000001420
resolver
ensp
ENSRNOP00000061895
resolver
ensp
ENSRNOP00000075023
resolver
genesymbol
Fis1
resolver
genesymbol_syn
Ttc11
resolver
uniprot
B2RZ80
resolver
uniprot
D4A5K3
resolver
uniprot_entry
FIS1_RAT
resolver
uniprot_sec
B2RZ80
resolver
uniprot_sec
D4A5K3
resolver
amino_acid_sequence
MEAVLNELVSVEDLKNFERKFQSEQAAGSVSKSTQFEYAWCLVRSKYNDDIRRGIVLLEELLPKGSKEEQRDYVFYLAVGNYRLKEYEKALKYVRGLLQTEPQNNQAKELERLIDKAMKKDGLVGMAIVGGMALGVAGLAGLIGLAVSKSKS
uniprot
proteins
function
FUNCTION: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering (PubMed:15979461). Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission (By similarity). May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event (By similarity). Also mediates peroxisomal fission (By similarity). May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis (By similarity). Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis (By similarity). {ECO:0000250|UniProtKB:Q9Y3D6, ECO:0000269|PubMed:15979461}.
uniprot
proteins
mass_dalton
16995
uniprot
proteins
mutagenesis
MUTAGEN 77; /note="L->A: Loss of mitochondrial fission-stimulating activity; when associated with A-84; A-91; A-97 and A-98."; /evidence="ECO:0000269|PubMed:15979461"; MUTAGEN 84; /note="L->A: Loss of mitochondrial fission-stimulating activity; when associated with A-77; A-91; A-97 and A-98."; /evidence="ECO:0000269|PubMed:15979461"; MUTAGEN 91; /note="L->A: Loss of mitochondrial fission-stimulating activity; when associated with A-77; A-84; A-97 and A-98."; /evidence="ECO:0000269|PubMed:15979461"; MUTAGEN 97; /note="L->A: Loss of mitochondrial fission-stimulating activity; when associated with A-77; A-84; A-91 and A-98."; /evidence="ECO:0000269|PubMed:15979461"; MUTAGEN 98; /note="L->A: Loss of mitochondrial fission-stimulating activity; when associated with A-77; A-84; A-91 and A-97."; /evidence="ECO:0000269|PubMed:15979461
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by MARCHF5. {ECO:0000250|UniProtKB:Q9Y3D6}.
uniprot
proteins
protein_family
FIS1 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15979461
uniprot
proteins
sequence_length
152
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:15979461}; Single-pass membrane protein {ECO:0000269|PubMed:15979461}. Peroxisome membrane {ECO:0000269|PubMed:15979461}; Single-pass membrane protein {ECO:0000269|PubMed:15979461}.
uniprot
proteins
transmembrane_region
TRANSMEM 123..143; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins