Adh5
entrez
11532
canonical
uniprot
P28474
canonical
ensembl
ENSMUSG00000028138
resolver
ensp
ENSMUSP00000005964
resolver
enst
ENSMUST00000005964
resolver
genesymbol
Adh5
resolver
genesymbol_syn
Adh-2
resolver
genesymbol_syn
Adh2
resolver
uniprot
Q3TW83
resolver
uniprot
Q6P5I3
resolver
uniprot
Q8C662
resolver
uniprot_entry
ADHX_MOUSE
resolver
uniprot_entry
Q6P5I3_MOUSE
resolver
uniprot_sec
Q3TW83
resolver
uniprot_sec
Q8C662
resolver
amino_acid_sequence
MANQVIRCKAAVAWEAGKPLSIEEIEVAPPKAHEVRIKILATAVCHTDAYTLSGADPEGCFPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGKGLMPDGTSRFTCKGKSVFHFMGTSTFSEYTVVADISVAKIDPSAPLDKVCLLGCGISTGYGAAVNTAKVEPGSTCAVFGLGGVGLAVIMGCKVAGASRIIGIDINKDKFAKAKEFGASECISPQDFSKSIQEVLVEMTDGGVDYSFECIGNVKVMRSALEAAHKGWGVSVVVGVAASGEEISTRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTGNLSFDQINQAFDLMHSGDSIRTVLKM
uniprot
proteins
ec_number
1.1.1.-
uniprot
proteins
ec_number
1.1.1.1
uniprot
proteins
ec_number
1.1.1.284
uniprot
proteins
function
FUNCTION: Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione (By similarity). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (By similarity). Class-III ADH is remarkably ineffective in oxidizing ethanol (By similarity). Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage (By similarity). Also acts as a S-nitroso-glutathione reductase by catalyzing the NADH-dependent reduction of S-nitrosoglutathione, thereby regulating protein S-nitrosylation (PubMed:11260719, PubMed:14980227). {ECO:0000250|UniProtKB:P11766, ECO:0000269|PubMed:11260719, ECO:0000269|PubMed:14980227}.
uniprot
proteins
mass_dalton
39548
uniprot
proteins
protein_family
Class-III subfamily
uniprot
proteins
protein_family
Zinc-containing alcohol dehydrogenase family
uniprot
proteins
pubmed
11260719
uniprot
proteins
pubmed
1472709
uniprot
proteins
pubmed
14980227
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
2053480
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
7738026
uniprot
proteins
pubmed
8647091
uniprot
proteins
sequence_length
374
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
uniprot
proteins