Nos1
entrez
24598
canonical
uniprot
P29476
canonical
ensembl
ENSRNOG00000001130
resolver
ensp
ENSRNOP00000001493
resolver
ensp
ENSRNOP00000062735
resolver
enst
ENSRNOT00000001493
resolver
enst
ENSRNOT00000066810
resolver
genesymbol
Nos1
resolver
genesymbol_syn
Bnos
resolver
uniprot
D3ZEW7
resolver
uniprot
F1LQL1
resolver
uniprot
P70594
resolver
uniprot_entry
D3ZEW7_RAT
resolver
uniprot_entry
F1LQL1_RAT
resolver
uniprot_entry
NOS1_RAT
resolver
uniprot_sec
P70594
resolver
activity_regulation
ACTIVITY REGULATION: Stimulated by calcium/calmodulin (PubMed:1712077). Inhibited by DYNLL1 that prevents the dimerization of the protein (PubMed:15548660, PubMed:8864115). Inhibited by NOSIP (PubMed:15548660). {ECO:0000269|PubMed:15548660, ECO:0000269|PubMed:1712077, ECO:0000269|PubMed:8864115}.
uniprot
proteins
amino_acid_sequence
MEENTFGVQQIQPNVISVRLFKRKVGGLGFLVKERVSKPPVIISDLIRGGAAEQSGLIQAGDIILAVNDRPLVDLSYDSALEVLRGIASETHVVLILRGPEGFTTHLETTFTGDGTPKTIRVTQPLGPPTKAVDLSHQPSASKDQSLAVDRVTGLGNGPQHAQGHGQGAGSVSQANGVAIDPTMKSTKANLQDIGEHDELLKEIEPVLSILNSGSKATNRGGPAKAEMKDTGIQVDRDLDGKSHKAPPLGGDNDRVFNDLWGKDNVPVILNNPYSEKEQSPTSGKQSPTKNGSPSRCPRFLKVKNWETDVVLTDTLHLKSTLETGCTEHICMGSIMLPSQHTRKPEDVRTKDQLFPLAKEFLDQYYSSIKRFGSKAHMDRLEEVNKEIESTSTYQLKDTELIYGAKHAWRNASRCVGRIQWSKLQVFDARDCTTAHGMFNYICNHVKYATNKGNLRSAITIFPQRTDGKHDFRVWNSQLIRYAGYKQPDGSTLGDPANVQFTEICIQQGWKAPRGRFDVLPLLLQANGNDPELFQIPPELVLEVPIRHPKFDWFKDLGLKWYGLPAVSNMLLEIGGLEFSACPFSGWYMGTEIGVRDYCDNSRYNILEEVAKKMDLDMRKTSSLWKDQALVEINIAVLYSFQSDKVTIVDHHSATESFIKHMENEYRCRGGCPADWVWIVPPMSGSITPVFHQEMLNYRLTPSFEYQPDPWNTHVWKGTNGTPTKRRAIGFKKLAEAVKFSAKLMGQAMAKRVKATILYATETGKSQAYAKTLCEIFKHAFDAKAMSMEEYDIVHLEHEALVLVVTSTFGNGDPPENGEKFGCALMEMRHPNSVQEERKSYKVRFNSVSSYSDSRKSSGDGPDLRDNFESTGPLANVRFSVFGLGSRAYPHFCAFGHAVDTLLEELGGERILKMREGDELCGQEEAFRTWAKKVFKAACDVFCVGDDVNIEKPNNSLISNDRSWKRNKFRLTYVAEAPDLTQGLSNVHKKRVSAARLLSRQNLQSPKFSRSTIFVRLHTNGNQELQYQPGDHLGVFPGNHEDLVNALIERLEDAPPANHVVKVEMLEERNTALGVISNWKDESRLPPCTIFQAFKYYLDITTPPTPLQLQQFASLATNEKEKQRLLVLSKGLQEYEEWKWGKNPTMVEVLEEFPSIQMPATLLLTQLSLLQPRYYSISSSPDMYPDEVHLTVAIVSYHTRDGEGPVHHGVCSSWLNRIQADDVVPCFVRGAPSFHLPRNPQVPCILVGPGTGIAPFRSFWQQRQFDIQHKGMNPCPMVLVFGCRQSKIDHIYREETLQAKNKGVFRELYTAYSREPDRPKKYVQDVLQEQLAESVYRALKEQGGHIYVCGDVTMAADVLKAIQRIMTQQGKLSEEDAGVFISRLRDDNRYHEDIFGVTLRTYEVTNRLRSESIAFIEESKKDADEVFSS
uniprot
proteins
ec_number
1.14.13.39
uniprot
proteins
function
FUNCTION: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. {ECO:0000269|PubMed:15548660, ECO:0000269|PubMed:1712077, ECO:0000269|PubMed:35772285}.
uniprot
proteins
mass_dalton
160559
uniprot
proteins
mutagenesis
MUTAGEN 588; /note="Y->F: No decrease in nitric-oxide synthase activity."; /evidence="ECO:0000269|PubMed:11237702"; MUTAGEN 588; /note="Y->H: 50% decrease of nitric-oxide synthase activity."; /evidence="ECO:0000269|PubMed:11237702"; MUTAGEN 588; /note="Y->S: 30% decrease of nitric-oxide synthase activity."; /evidence="ECO:0000269|PubMed:11237702
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; mediated by STUB1/CHIP in the presence of Hsp70 and Hsp40 (in vitro). {ECO:0000269|PubMed:15466472}.
uniprot
proteins
protein_family
NOS family
uniprot
proteins
pubmed
10221915
uniprot
proteins
pubmed
11086993
uniprot
proteins
pubmed
11237702
uniprot
proteins
pubmed
11473123
uniprot
proteins
pubmed
11867766
uniprot
proteins
pubmed
15105416
uniprot
proteins
pubmed
15208315
uniprot
proteins
pubmed
15466472
uniprot
proteins
pubmed
15548660
uniprot
proteins
pubmed
1712077
uniprot
proteins
pubmed
17161399
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23300088
uniprot
proteins
pubmed
35772285
uniprot
proteins
pubmed
7520037
uniprot
proteins
pubmed
7530005
uniprot
proteins
pubmed
8806605
uniprot
proteins
pubmed
8864115
uniprot
proteins
sequence_length
1429
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q9Z0J4}; Peripheral membrane protein {ECO:0000255}. Cell projection, dendritic spine {ECO:0000269|PubMed:15548660}. Note=In skeletal muscle, it is localized beneath the sarcolemma of fast-twitch muscle fiber by associating with the dystrophin glycoprotein complex (By similarity). In neurons, enriched in dendritic spines (PubMed:15548660). {ECO:0000250|UniProtKB:Q9Z0J4, ECO:0000269|PubMed:15548660}.
uniprot
proteins