Adig
entrez
246747
canonical
uniprot
Q8R400
canonical
ensembl
ENSMUSG00000044405
resolver
ensp
ENSMUSP00000051732
resolver
enst
ENSMUST00000059889
resolver
genesymbol
Adig
resolver
genesymbol_syn
Smaf1
resolver
uniprot_entry
ADIG_MOUSE
resolver
amino_acid_sequence
MKYPLVPLVSDLTLSFLVFWLCLPVALLLFLTIVWLHFLLSQESKEDDSDLCFNWEPWSKRPSECGCEETFPGEEDGLHW
uniprot
proteins
function
FUNCTION: Key regulator of lipid storage that promotes the expansion of lipid droplets during the formation of mature adipocytes (PubMed:16132694, PubMed:33691105, PubMed:41196993). Acts by forming a dodecameric complex with seipin (BSCL2) when adipocytes have differentiated and are undergoing maturation (PubMed:41196993). In the dodecameric complex, ADIG antagonizes the activity of BSCL2 by reducing BSCL2-mediated triacylglycerol nucleation and relieving BSCL2's inhibition of GPAT3 and GPAT4 (PubMed:41196993). GPAT3 and GPAT4 then translocate to lipid droplets, promoting the synthesis of triacylglycerols and the expansion of lipid droplets (PubMed:41196993). {ECO:0000269|PubMed:16132694, ECO:0000269|PubMed:33691105, ECO:0000269|PubMed:41196993}.
uniprot
proteins
mass_dalton
9362
uniprot
proteins
protein_family
Adipogenin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15567149
uniprot
proteins
pubmed
16132694
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
33691105
uniprot
proteins
pubmed
41196993
uniprot
proteins
sequence_length
80
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:41196993}; Single-pass membrane protein {ECO:0000269|PubMed:41196993}. Nucleus {ECO:0000269|PubMed:15567149, ECO:0000269|PubMed:16132694}.
uniprot
proteins
transmembrane_region
TRANSMEM 14..39; /note="Helical"; /evidence="ECO:0000269|PubMed:41196993, ECO:0007744|PDB:9C8D
uniprot
proteins