Kmo
entrez
59113
canonical
uniprot
O88867
canonical
ensembl
ENSRNOG00000003709
resolver
ensembl
ENSRNOG00065023432
resolver
ensp
ENSRNOP00000005005
resolver
ensp
ENSRNOP00065032731
resolver
enst
ENSRNOT00000005005
resolver
enst
ENSRNOT00065040227
resolver
genesymbol
Kmo
resolver
uniprot_entry
KMO_RAT
resolver
amino_acid_sequence
MASSDTEGKRVVVIGGGLVGALNACFLAKRNFQVDVYEAREDIRVANFMRGRSINLALSYRGRQALKAVGLEDQIVSKGVPMKARMIHSLSGKKSAIPYGNKSQYILSISREKLNKDLLTAVESYPNAKVHFGHKLSKCCPEEGILTMLGPNKVPRDITCDLIVGCDGAYSTVRAHLMKKPRFDYSQQYIPHGYMELTIPPKNGEYAMEPNCLHIWPRNAFMMIALPNMDKSFTCTLFMSFEEFEKLPTHSDVLDFFQKNFPDAIPLMGEQALMRDFFLLPAQPMISVKCSPFHLKSRCVLMGDAAHAIVPFFGQGMNAGFEDCLVFDELMDKFNNDLSVCLPEFSRFRIPDDHAISDLSMYNYIEMRAHVNSRWFLFQRLLDKFLHALMPSTFIPLYTMVAFTRIRYHEAVLRWHWQKKVINRGLFVLGSLVAIGSAYILVHHLSPRPLELLRSAWTGTSGHWNRSADISPRVPWSH
uniprot
proteins
ec_number
1.14.13.9
uniprot
proteins
function
FUNCTION: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. {ECO:0000255|HAMAP-Rule:MF_03018, ECO:0000269|PubMed:26752518, ECO:0000269|PubMed:28398044}.
uniprot
proteins
mass_dalton
54353
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3. {ECO:0000255|HAMAP-Rule:MF_03018}.
uniprot
proteins
protein_family
Aromatic-ring hydroxylase family
uniprot
proteins
protein_family
KMO subfamily
uniprot
proteins
pubmed
12402501
uniprot
proteins
pubmed
1332540
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
26752518
uniprot
proteins
pubmed
28398044
uniprot
proteins
sequence_length
478
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000255|HAMAP-Rule:MF_03018, ECO:0000269|PubMed:1332540}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03018, ECO:0000269|PubMed:1332540}.
uniprot
proteins
transmembrane_region
TRANSMEM 385..404; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03018"; TRANSMEM 425..445; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03018
uniprot
proteins