CRK
entrez
1398
canonical
uniprot
P46108
canonical
ensembl
ENSG00000167193
resolver
ensp
ENSP00000300574
resolver
ensp
ENSP00000381942
resolver
genesymbol
CRK
resolver
hgnc
HGNC:2362
resolver
uniprot
A0A0S2Z3K9
resolver
uniprot
A0A0S2Z3Q4
resolver
uniprot
A8MWE8
resolver
uniprot
B0LPE8
resolver
uniprot
D3DTH6
resolver
uniprot
Q96GA9
resolver
uniprot
Q96HJ0
resolver
uniprot_entry
A0A0S2Z3K9_HUMAN
resolver
uniprot_entry
A0A0S2Z3Q4_HUMAN
resolver
uniprot_entry
CRK_HUMAN
resolver
uniprot_sec
A8MWE8
resolver
uniprot_sec
B0LPE8
resolver
uniprot_sec
D3DTH6
resolver
uniprot_sec
Q96GA9
resolver
uniprot_sec
Q96HJ0
resolver
amino_acid_sequence
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPDEDFS
uniprot
proteins
function
FUNCTION: Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. {ECO:0000269|PubMed:12432078}.; FUNCTION: [Isoform Crk-II]: Regulates cell adhesion, spreading and migration (PubMed:31311869). Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4 (PubMed:19004829). May regulate the EFNA5-EPHA3 signaling (By similarity). {ECO:0000250|UniProtKB:Q64010, ECO:0000269|PubMed:11870224, ECO:0000269|PubMed:1630456, ECO:0000269|PubMed:17515907, ECO:0000269|PubMed:19004829, ECO:0000269|PubMed:31311869}.
uniprot
proteins
mass_dalton
33831
uniprot
proteins
mutagenesis
MUTAGEN 150; /note="D->K: Abolishes interaction with DOCK1."; /evidence="ECO:0000269|PubMed:8662907"; MUTAGEN 169; /note="W->K: Abolishes interaction with PEAK3."; /evidence="ECO:0000269|PubMed:31311869"; MUTAGEN 169; /note="W->L: Abolishes interaction with DOCK5. Abolishes RAP1 activation."; /evidence="ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:19004829"; MUTAGEN 275; /note="W->K: No effect on interaction with PEAK3."; /evidence="ECO:0000269|PubMed:31311869
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Tyr-221 upon cell adhesion. Results in the negative regulation of the association with SH2- and SH3-binding partners, possibly by the formation of an intramolecular interaction of phosphorylated Tyr-221 with the SH2 domain. This leads finally to the down-regulation of the Crk signaling pathway (PubMed:17515907). Isoform Crk-II: Phosphorylated by KIT (By similarity). {ECO:0000250|UniProtKB:Q64010, ECO:0000269|PubMed:17515907}.; PTM: Proline isomerization at Pro-237 by PPIA acts as a switch between two conformations: an autoinhibitory conformation in the cis form, where the tandem SH3 domains interact intramolecularly, and an activated conformation in the trans form. {ECO:0000250}.
uniprot
proteins
protein_family
CRK family
uniprot
proteins
pubmed
10362357
uniprot
proteins
pubmed
10733900
uniprot
proteins
pubmed
10964504
uniprot
proteins
pubmed
11870224
uniprot
proteins
pubmed
12384576
uniprot
proteins
pubmed
12432078
uniprot
proteins
pubmed
12628187
uniprot
proteins
pubmed
12878163
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16076871
uniprot
proteins
pubmed
16129412
uniprot
proteins
pubmed
1630456
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17038317
uniprot
proteins
pubmed
17515907
uniprot
proteins
pubmed
18024423
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19004829
uniprot
proteins
pubmed
19381274
uniprot
proteins
pubmed
19807924
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20534451
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
31311869
uniprot
proteins
pubmed
8378094
uniprot
proteins
pubmed
8657152
uniprot
proteins
pubmed
8662907
uniprot
proteins
pubmed
9614078
uniprot
proteins
sequence_length
304
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocated to the plasma membrane upon cell adhesion. {ECO:0000250}.
uniprot
proteins