Srgap2
entrez
360840
canonical
uniprot
D4A208
canonical
ensembl
ENSRNOG00000006733
resolver
ensembl
ENSRNOG00055020451
resolver
ensembl
ENSRNOG00060014960
resolver
ensembl
ENSRNOG00065019261
resolver
ensp
ENSRNOP00000008976
resolver
ensp
ENSRNOP00000068925
resolver
ensp
ENSRNOP00000070956
resolver
ensp
ENSRNOP00000112019
resolver
ensp
ENSRNOP00055028360
resolver
ensp
ENSRNOP00060020475
resolver
ensp
ENSRNOP00065025918
resolver
enst
ENSRNOT00000008976
resolver
enst
ENSRNOT00000085967
resolver
enst
ENSRNOT00000086928
resolver
enst
ENSRNOT00000127076
resolver
enst
ENSRNOT00055034950
resolver
enst
ENSRNOT00060025648
resolver
enst
ENSRNOT00065032469
resolver
genesymbol
Srgap2
resolver
uniprot
A0A0G2JZ92
resolver
uniprot
A0ABK0LM79
resolver
uniprot
B5DEJ1
resolver
uniprot
F7ETY2
resolver
uniprot_entry
A0A0G2JZ92_RAT
resolver
uniprot_entry
A0ABK0LM79_RAT
resolver
uniprot_entry
B5DEJ1_RAT
resolver
uniprot_entry
F7ETY2_RAT
resolver
uniprot_entry
SRGP2_RAT
resolver
amino_acid_sequence
MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIYLNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLALEATNASVFKYYIHDLSDIIDQCCDLGYHASLNRALRTFLSAELNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQQPVQSELVQRRQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSMESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLGESQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLRHEGVFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLIACVTMDNLQERAVHIRKVLLVLPKPTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTIIIQHENIFPNPRELEGPIYSRGGSMEDYCDSTHGETISAEDSTQDVTAEHHTSDDECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPKSEIEVMSEPPEEKVTARTGASCPSGGHVADIYLANINKQRKRPESGSIRKAFRSDSHGLGSSLTDSSSPGVGASCRPSSQPIMSQNLPKEGPDKCSISGHGSLNSISRHSSLKNRMDSPQIRKTATAGRSKSFNNHRPMDPEVIAQDIEATMNSALNELQELERQSSAKHTPDVVLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDPEPAFQRSASTAGDIACAFRPVKSVKMAAPVKPPATRPKPTVFPKTNATSPGVNSSASPQSTDKSCTV
uniprot
proteins
function
FUNCTION: Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex. Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons. SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses. Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation. Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions. In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia. {ECO:0000250|UniProtKB:Q91Z67}.
uniprot
proteins
mass_dalton
120878
uniprot
proteins
post_translational_modification
PTM: Methylation at Arg-927 is required for the stimulation of cell migration, dimerization and localization at the plasma membrane protrusions. {ECO:0000250|UniProtKB:O75044}.
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
17710530
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
27748913
uniprot
proteins
sequence_length
1071
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O75044}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:O75044}. Postsynaptic density {ECO:0000250|UniProtKB:Q91Z67}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q91Z67}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:O75044}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q91Z67}. Nucleus {ECO:0000269|PubMed:17710530, ECO:0000269|PubMed:27748913}. Cytoplasm, cytosol {ECO:0000269|PubMed:17710530, ECO:0000269|PubMed:27748913}. Note=Recruited to actin-rich phagosomes during phagocytosis (By similarity). Translocates from nucleus to cytoplasm during development (PubMed:17710530). {ECO:0000250|UniProtKB:Q91Z67, ECO:0000269|PubMed:17710530}.
uniprot
proteins