ANAPC16
entrez
119504
canonical
uniprot
Q96DE5
canonical
ensembl
ENSG00000166295
resolver
ensp
ENSP00000299381
resolver
ensp
ENSP00000477760
resolver
ensp
ENSP00000478792
resolver
ensp
ENSP00000572491
resolver
ensp
ENSP00000572492
resolver
ensp
ENSP00000572493
resolver
ensp
ENSP00000572494
resolver
ensp
ENSP00000572495
resolver
ensp
ENSP00000572496
resolver
ensp
ENSP00000572497
resolver
ensp
ENSP00000572498
resolver
ensp
ENSP00000572499
resolver
ensp
ENSP00000572500
resolver
ensp
ENSP00000572501
resolver
ensp
ENSP00000572502
resolver
ensp
ENSP00000572503
resolver
ensp
ENSP00000572504
resolver
ensp
ENSP00000572505
resolver
ensp
ENSP00000584354
resolver
ensp
ENSP00000584355
resolver
ensp
ENSP00000584357
resolver
ensp
ENSP00000584358
resolver
ensp
ENSP00000584359
resolver
ensp
ENSP00000584360
resolver
ensp
ENSP00000627490
resolver
ensp
ENSP00000627491
resolver
ensp
ENSP00000627492
resolver
ensp
ENSP00000627493
resolver
ensp
ENSP00000627494
resolver
ensp
ENSP00000627495
resolver
ensp
ENSP00000627496
resolver
enst
ENST00000299381
resolver
enst
ENST00000615507
resolver
enst
ENST00000621663
resolver
enst
ENST00000902432
resolver
enst
ENST00000902433
resolver
enst
ENST00000902434
resolver
enst
ENST00000902435
resolver
enst
ENST00000902436
resolver
enst
ENST00000902437
resolver
enst
ENST00000902438
resolver
enst
ENST00000902439
resolver
enst
ENST00000902440
resolver
enst
ENST00000902441
resolver
enst
ENST00000902442
resolver
enst
ENST00000902443
resolver
enst
ENST00000902444
resolver
enst
ENST00000902445
resolver
enst
ENST00000902446
resolver
enst
ENST00000914295
resolver
enst
ENST00000914296
resolver
enst
ENST00000914298
resolver
enst
ENST00000914299
resolver
enst
ENST00000914300
resolver
enst
ENST00000914301
resolver
enst
ENST00000957431
resolver
enst
ENST00000957432
resolver
enst
ENST00000957433
resolver
enst
ENST00000957434
resolver
enst
ENST00000957435
resolver
enst
ENST00000957436
resolver
enst
ENST00000957437
resolver
genesymbol
ANAPC16
resolver
genesymbol
C10orf104
resolver
genesymbol_syn
C10orf104
resolver
genesymbol_syn
CENP-27
resolver
hgnc
HGNC:26976
resolver
uniprot
A0A087WUN5
resolver
uniprot
C5H3H2
resolver
uniprot_entry
A0A087WUN5_HUMAN
resolver
uniprot_entry
APC16_HUMAN
resolver
uniprot_entry
C5H3H2_HUMAN
resolver
amino_acid_sequence
MAASSSSSSAGGVSGSSVTGSGFSVSDLAPPRKALFTYPKGAGEMLEDGSERFLCESVFSYQVASTLKQVKHDQQVARMEKLAGLVEELEADEWRFKPIEQLLGFTPSSG
uniprot
proteins
function
FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (PubMed:20360068, PubMed:27120157, PubMed:27509861). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:20360068). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (PubMed:27120157, PubMed:27509861). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (PubMed:27509861). {ECO:0000269|PubMed:20360068, ECO:0000269|PubMed:27120157, ECO:0000269|PubMed:27509861, ECO:0000269|PubMed:29033132}.
uniprot
proteins
mass_dalton
11667
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:20360068, ECO:0000269|PubMed:29033132}.
uniprot
proteins
protein_family
APC16 family
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20360068
uniprot
proteins
pubmed
20813266
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
25043029
uniprot
proteins
pubmed
26083744
uniprot
proteins
pubmed
27120157
uniprot
proteins
pubmed
27509861
uniprot
proteins
pubmed
29033132
uniprot
proteins
sequence_length
110
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20360068}. Nucleus {ECO:0000269|PubMed:20360068}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:20813266}.
uniprot
proteins