Cobalamin biosynthesis
uniprot_keyword
KW-0169
canonical
name
Cobalamin biosynthesis
uniprot
synonym
Cobalamin anabolism
uniprot
synonym
Cobalamin biosynthetic process
uniprot
synonym
Cobalamin formation
uniprot
synonym
Cobalamin synthesis
uniprot
synonym
Vitamin B12 anabolism
uniprot
synonym
Vitamin B12 biosynthesis
uniprot
synonym
Vitamin B12 biosynthetic process
uniprot
synonym
Vitamin B12 formation
uniprot
synonym
Vitamin B12 synthesis
uniprot
definition
Protein involved in the synthesis of cobalamin. Cobalamin, which is synthesized by microorganisms, has equatorial sites occupied by a modified porphyrin ring system, with two of the four pyrrol rings fused directly (without an intervening methine bridge). The modified porphyrin system binds a cobalt(III) ion in the center, and this is called a corrin ring system. One axial site is occupied usually by an intramolecularly-bound dimethylbenzimidazole nucleotide and the other axial site is occupied by a number of different ligands such as water (aquacobalamin), cyanide (cyanocobalamine=vitamin B12), glutathione (glutathionylcobalamine), 5'deoxyadenosine (adenosylcobalamine=coenzyme B12) or a methyl group (methylcobalamin). Vitamin B12, for instance, is a prosthetic group of certain mammalian enzymes, where it is essential for the normal maturation and development of erythrocytes. A deficiency in the diet or more frequently the failure to absorb the vitamin B12 give rise to pernicious anemia.
uniprot
keywords
is_obsolete
false
uniprot
keywords
ontology_id
uniprot_keywords
uniprot
keywords