PSMA3
entrez
5684
canonical
uniprot
P25788
canonical
ensembl
ENSG00000100567
resolver
ensp
ENSP00000216455
resolver
ensp
ENSP00000390491
resolver
genesymbol
PSMA3
resolver
genesymbol_syn
HC8
resolver
genesymbol_syn
PSC8
resolver
hgnc
HGNC:9532
resolver
uniprot
A0A140VK43
resolver
uniprot
B2RCK6
resolver
uniprot
Q86U83
resolver
uniprot
Q8N1D8
resolver
uniprot
Q9BS70
resolver
uniprot_entry
A0A140VK43_HUMAN
resolver
uniprot_entry
PSA3_HUMAN
resolver
uniprot_sec
B2RCK6
resolver
uniprot_sec
Q86U83
resolver
uniprot_sec
Q8N1D8
resolver
uniprot_sec
Q9BS70
resolver
amino_acid_sequence
MSSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTCRDIVKEVAKIIYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYAKESLKEEDESDDDNM
uniprot
proteins
function
FUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2. {ECO:0000269|PubMed:11350925, ECO:0000269|PubMed:14550573, ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:17499743, ECO:0000269|PubMed:27176742}.
uniprot
proteins
mass_dalton
28433
uniprot
proteins
protein_family
Peptidase T1A family
uniprot
proteins
pubmed
11350925
uniprot
proteins
pubmed
11521686
uniprot
proteins
pubmed
12181345
uniprot
proteins
pubmed
12376572
uniprot
proteins
pubmed
12472671
uniprot
proteins
pubmed
14550573
uniprot
proteins
pubmed
14674694
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15244466
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15831937
uniprot
proteins
pubmed
15936278
uniprot
proteins
pubmed
16298756
uniprot
proteins
pubmed
16337594
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17323924
uniprot
proteins
pubmed
17487921
uniprot
proteins
pubmed
17499743
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18971267
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
2025653
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23495936
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25599644
uniprot
proteins
pubmed
26133119
uniprot
proteins
pubmed
26524591
uniprot
proteins
pubmed
26657688
uniprot
proteins
pubmed
26829627
uniprot
proteins
pubmed
27176742
uniprot
proteins
pubmed
27342858
uniprot
proteins
pubmed
27428775
uniprot
proteins
pubmed
27493187
uniprot
proteins
pubmed
34711951
uniprot
proteins
pubmed
7811265
uniprot
proteins
pubmed
8610016
uniprot
proteins
sequence_length
255
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Nucleus {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000269|PubMed:34711951}.
uniprot
proteins