Sun2
entrez
223697
canonical
uniprot
Q8BJS4
canonical
ensembl
ENSMUSG00000042524
resolver
ensp
ENSMUSP00000047864
resolver
ensp
ENSMUSP00000086724
resolver
ensp
ENSMUSP00000098006
resolver
genesymbol
Sun2
resolver
genesymbol_syn
Unc84b
resolver
uniprot
Q3TBU0
resolver
uniprot
Q3U160
resolver
uniprot
Q4QQM3
resolver
uniprot
Q6B4H2
resolver
uniprot_entry
Q4QQM3_MOUSE
resolver
uniprot_entry
SUN2_MOUSE
resolver
uniprot_sec
Q3TBU0
resolver
uniprot_sec
Q3U160
resolver
uniprot_sec
Q6B4H2
resolver
amino_acid_sequence
MSRRSQRLTRYSQDDNDGGSSSSGASSVAGSQGTVFKDSPLRTLKRKSSNMKHLSPAPQLGPSSDSHTSYYSESVVRESYIGSPRAVSLARSALLDDHLHSEPYWSGDLRGRRRRGTGGSESSKANGLTAESKASEDFFGSSSGYSSEDDLAGYTDSDQHSSGSRLRSAASRAGSFVWTLVTFPGRLFGLLYWWIGTTWYRLTTAASLLDVFVLTRSRHFSLNLKSFLWFLLLLLLLTGLTYGAWHFYPLGLQTLQPAVVSWWAAKESRKQPEVWESRDASQHFQAEQRVLSRVHSLERRLEALAADFSSNWQKEAIRLERLELRQGAAGHGGGSSLSHEDALSLLEGLVSRREATLKEDLRRDTVAHIQEELATLRAEHHQDSEDLFKKIVQASQESEARVQQLKTEWKSMTQEAFQESSVKELGRLEAQLASLRQELAALTLKQNSVADEVGLLPQKIQAARADVESQFPDWIRQFLLGDRGARSGLLQRDEMHAQLQELENKILTKMAEMQGKSAREAAASLGQILQKEGIVGVTEEQVHRIVKQALQRYSEDRIGMVDYALESGGASVISTRCSETYETKTALLSLFGIPLWYHSQSPRVILQPDVHPGNCWAFQGPQGFAVVRLSARIRPTAVTLEHVPKALSPNSTISSAPKDFAIFGFDEDLQQEGTLLGTFAYDQDGEPIQTFYFQASKMATYQVVELRILTNWGHPEYTCIYRFRVHGEPAH
uniprot
proteins
function
FUNCTION: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Required for nuclear migration in retinal photoreceptor progenitors implicating association with cytoplasmic dynein-dynactin and kinesin motor complexes, and probably B-type lamins; SUN1 and SUN2 seem to act redundantly. The SUN1/2:KASH5 LINC complex couples telomeres to microtubules during meiosis; SUN1 and SUN2 seem to act at least partial redundantly. Anchors chromosome movement in the prophase of meiosis and is involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Required for telomere attachment to nuclear envelope and gametogenesis. May also function on endocytic vesicles as a receptor for Rab5-GDP and participate in the activation of Rab5. {ECO:0000269|PubMed:16380439, ECO:0000269|PubMed:19509342, ECO:0000269|PubMed:19843581, ECO:0000269|PubMed:19874786, ECO:0000269|PubMed:20724637, ECO:0000269|PubMed:21177258, ECO:0000269|PubMed:23071752, ECO:0000269|PubMed:24586178, ECO:0000305}.
uniprot
proteins
mass_dalton
81605
uniprot
proteins
mutagenesis
MUTAGEN 432; /note="L->A: Disrupts homotrimerization; disrupts interaction with SYNE2; when associated with A-435."; /evidence="ECO:0000269|PubMed:26688217"; MUTAGEN 435; /note="L->A: Disrupts homotrimerization; disrupts interaction with SYNE2; when associated with A-432."; /evidence="ECO:0000269|PubMed:26688217"; MUTAGEN 446; /note="Q->L: Stabilizes homotrimerization; no effect on interaction with SYNE2."; /evidence="ECO:0000269|PubMed:26688217
uniprot
proteins
post_translational_modification
PTM: The disulfide bond with SYNE2 is required for stability of the SUN2:SYNE2/KASH2 LINC complex under tensile forces though not required for the interaction. The disulfide bond is proposed to be conserved in LINC complexes involved in force transmission. {ECO:0000250|UniProtKB:Q9UH99}.
uniprot
proteins
pubmed
12393179
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16380439
uniprot
proteins
pubmed
17132086
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19509342
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
19843581
uniprot
proteins
pubmed
19874786
uniprot
proteins
pubmed
19933576
uniprot
proteins
pubmed
20724637
uniprot
proteins
pubmed
21177258
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22349700
uniprot
proteins
pubmed
23071752
uniprot
proteins
pubmed
24586178
uniprot
proteins
pubmed
26688217
uniprot
proteins
pubmed
29878215
uniprot
proteins
sequence_length
731
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000269|PubMed:19933576}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9UH99}. Nucleus envelope {ECO:0000269|PubMed:17132086, ECO:0000269|PubMed:19843581, ECO:0000269|PubMed:19874786, ECO:0000269|PubMed:19933576}. Endosome membrane {ECO:0000250|UniProtKB:Q9UH99}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9UH99}. Note=Colocalizes with KASH5 at sites of telomere attachment in meiocytes. {ECO:0000269|PubMed:24586178}.
uniprot
proteins
transmembrane_region
TRANSMEM 227..247; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins