Elf4
entrez
56501
canonical
uniprot
Q9Z2U4
canonical
ensembl
ENSMUSG00000031103
resolver
ensp
ENSMUSP00000033429
resolver
ensp
ENSMUSP00000110608
resolver
ensp
ENSMUSP00000303250
resolver
enst
ENSMUST00000033429
resolver
enst
ENSMUST00000114958
resolver
genesymbol
Elf4
resolver
genesymbol_syn
Mef
resolver
uniprot
B1AY67
resolver
uniprot_entry
ELF4_MOUSE
resolver
uniprot_sec
B1AY67
resolver
amino_acid_sequence
MAIALQPSDLVFEFASNGMDDIHQLEDPSVFPAVIVEQVPYPELVHLCSGLDLDEVHNGIIRDRTLCMTQDQILEGSILLTDDDVSTSNNVSSTEVLFNVATPSDVLDEKQIFSSPEVLSDSNSVQAINLPNFLLSTPEPDDLKKTSDAGDQKEHSEEEKVSREENLRKMGKARKRNRKTKNNRSTSPVTDPSMPIRKKSKDGKGSTIYLWEFLLALLQDRNTCPKYIKWTQREKGIFKLVDSKAVSKLWGKQKNKPDMNYETMGRALRYYYQRGILAKVEGQRLVYQFKEMPKDLVVIDDEEESPETPEDSSQASTSSTPSTSTIRRASSRVGTRASPEDKDNPPWEKPKVQHTGLQPSASLELGLSVDEEVPTTSTMLASPLQSQARLTKTVSSSPAPSNIHLGVAPVGPGSTVTLQTIPLTTVLTNGPPASTTAPTQLVLQSVPQVSTFKDTFTLQTSFPLNTNLQENQVATQGAPLILSGLPQLLAGANPQSNPAPSQVIGAGSAGPSSQPPGTVIAAFIRTSSGTSVPVVKEGPLRSSSYVQGVVTGAPVEGLLVPEETLRELLRDQGHLQPLPSQVLSRGSHNLSLVGNQTLSPPSHPTVGLTPVAELELSSGSGPLFVTEPSVTRSPTQAPFSPFNPTSLIKMEPQDI
uniprot
proteins
function
FUNCTION: Transcriptional activator that binds to DNA sequences containing the consensus 5'-WGGA-3'. Transactivates promoters of the hematopoietic growth factor genes CSF2, IL3, IL8, and of LYZ. Acts synergistically with RUNX1 to transactivate the IL3 promoter (By similarity). Transactivates the PRF1 promoter in natural killer (NK) cells and in CD8+ T cells (PubMed:34326534). Plays a role in the development and function of NK and NK T-cells and in innate immunity. Controls the proliferation and homing of CD8+ T-cells via the Kruppel-like factors KLF4 and KLF2. Controls cell senescence in a p53-dependent manner. Can also promote cellular transformation through inhibition of the p16 pathway. Is a transcriptional regulator of inflammation, controlling T-helper 17 (Th17) cells and macrophage inflammatory responses. Required for sustained transcription of anti-inflammatory genes, including IL1RN (PubMed:34326534, PubMed:35266071). Is a negative regulator of pro-inflammatory cytokines expression, including IL17A, IL1B, IL6, TNFA and CXCL1 (PubMed:34326534, PubMed:35266071). Down-regulates expression of TREM1, a cell surface receptor involved in the amplification of inflammatory responses (PubMed:34326534, PubMed:35266071). {ECO:0000250, ECO:0000269|PubMed:12387738, ECO:0000269|PubMed:19380490, ECO:0000269|PubMed:19412182, ECO:0000269|PubMed:34326534, ECO:0000269|PubMed:35266071}.
uniprot
proteins
mass_dalton
70800
uniprot
proteins
mutagenesis
MUTAGEN 230; /note="W->R: Higher TNFA, IL1B and IL6 expression in bone marrow-derived and peritoneal macrophages from mutant mice compared to wild-type, after VSV infection. Decreased viral clearance in mutant mice compared to wild-type. Loss of transcriptional activity shown in IFNB1 promoter-driven luciferase assay."; /evidence="ECO:0000269|PubMed:35266071"; MUTAGEN 250; /note="W->S: Higher IL17A, IL1B, IL6, CXCL1 and TREM1 expression in bone marrow-derived macrophages from mutant mice compared to wild-type, after LPS stimulation. CD8+ T cells from mutant mice have reduced PRF1 expression when activated with IL-2 compared to cells from wild-type littermates."; /evidence="ECO:0000269|PubMed:34326534
uniprot
proteins
protein_family
ETS family
uniprot
proteins
pubmed
12387738
uniprot
proteins
pubmed
19380490
uniprot
proteins
pubmed
19412182
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
34326534
uniprot
proteins
pubmed
35266071
uniprot
proteins
sequence_length
655
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, PML body {ECO:0000250}. Note=Accumulation into PML nuclear bodies is mediated by PML. {ECO:0000250}.
uniprot
proteins