Clcn6
entrez
26372
canonical
uniprot
O35454
canonical
ensembl
ENSMUSG00000029016
resolver
ensp
ENSMUSP00000030879
resolver
enst
ENSMUST00000030879
resolver
genesymbol
Clcn6
resolver
genesymbol_syn
Clc6
resolver
uniprot
Q3UM91
resolver
uniprot_entry
CLCN6_MOUSE
resolver
uniprot_entry
Q3UM91_MOUSE
resolver
amino_acid_sequence
MAGCRGSVCCCCRWCCCCGERESRTPEELTILGETQEEEDEILPRKDYESLDYDRCINDPYLEVLETMDNKKGRRYEAVKWMVVFAIGVCTGLVGLFVDFSVRLFTQLKFGVVQTSVEECSQKGCLALSLLELLGFNLTFVFLASLLVLIEPVAAGSGIPEIKCYLNGVKVPGIVRLRTLLCKVFGVLFSVSGGLFVGKEGPMIHSGAVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEEGSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCHLWTAMDLGFFVVMGVIGGLLGATFNCLNKRLAKYRMRNVHPKPKLVRVLESLLVSLVTTVVVFVASMVLGECRQMSSTSQTGNGSFQLQVTSEDVNSTIKAFFCPNDTYNDMATLFFNSQESAILQLFHQDGTFSPVTLALFFILYFLLACWTFGTSVPSGLFVPSLLCGAAFGRLVANVLKSYIGLGHLYSGTFALIGAAAFLGGVVRMTISLTVILIESTNEITYGLPIMVTLMVAKWTGDLFNKGIYDVHIGLRGVPLLEWETDVEMDKLRASDIMEPNLTYVYPHTRIQSLVSILRTTVHHAFPVVTENRGNEKEFMKGNQLISNNIKFKKSSILTRAGEQRKRGQSMKSYPSSELRNVCDEHVASEEPAEKEDLLQQMLERRYTPYPNLYPDQSPSEDWTMEERFRPLTFHGLVLRSQLVTLLVRGVCYSESQSSASQPRLSYAEMAEDYPRYPDIHDLDLTLLNPRMIVDVTPYMNPSPFTVSPNTHVSQVFNLFRTMGLRHLPVVNAVGEIVGIITRHNLTNEFLQARLRQHYQTL
uniprot
proteins
function
FUNCTION: Voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the late endosome lumen. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters. {ECO:0000269|PubMed:16950870}.
uniprot
proteins
mass_dalton
96980
uniprot
proteins
post_translational_modification
PTM: N-glycosylated on several asparagine residues. {ECO:0000250|UniProtKB:P51797}.
uniprot
proteins
protein_family
Chloride channel (TC 2.A.49) family
uniprot
proteins
protein_family
ClC-6/CLCN6 subfamily
uniprot
proteins
pubmed
16950870
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9224655
uniprot
proteins
sequence_length
870
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:16950870}; Multi-pass membrane protein {ECO:0000269|PubMed:16950870}.
uniprot
proteins
transmembrane_region
TRANSMEM 81..113; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 128..150; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 176..194; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 200..217; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 277..294; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 335..364; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 371..392; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 463..482; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 488..512; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 554..572; /note="Helical"; /evidence="ECO:0000250
uniprot
proteins