Cidec
entrez
500292
canonical
uniprot
Q5XI33
canonical
ensembl
ENSRNOG00000009153
resolver
ensp
ENSRNOP00000012136
resolver
ensp
ENSRNOP00000073293
resolver
ensp
ENSRNOP00000090307
resolver
enst
ENSRNOT00000012136
resolver
enst
ENSRNOT00000091965
resolver
genesymbol
Cidec
resolver
genesymbol_syn
Fsp27
resolver
uniprot
A0A0G2K551
resolver
uniprot_entry
A0A0G2K551_RAT
resolver
uniprot_entry
CIDEC_RAT
resolver
amino_acid_sequence
MDYAMKSLSLLYPRSLSRHVAVSTAVVTQQLVSEPSRETPRARPCRVSTADRKVRKGIMAHSLEDLLGKVQDILKLKDKPFSLVLEEDGTIVETEEYFQALPRDTVFMVLQKGQKWKSPSEQRKKKAQLSLSQKPTKKIDVARVTFDLYKLNPQDFIGCLNVKATLYDTYSLSYDLHCYRAKRIVKEMLRWTLFSMQATGHMLLGTSSYMQQFLDATEEEQPSKAKASLLPACLKMLQ
uniprot
proteins
function
FUNCTION: Lipid transferase specifically expressed in white adipose tissue, which promotes unilocular lipid droplet formation by mediating lipid droplet fusion (By similarity). Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage (By similarity). Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by undergoing liquid-liquid phase separation (LLPS) and promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (By similarity). The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair (By similarity). Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1 (By similarity). May also act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH (PubMed:23233732). When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment (By similarity). {ECO:0000250|UniProtKB:P56198, ECO:0000250|UniProtKB:Q96AQ7, ECO:0000269|PubMed:23233732}.
uniprot
proteins
mass_dalton
27214
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated and targeted to proteasomal degradation, resulting in a short half-life (about 15 minutes in 3T3-L1 cells). Protein stability depends on triaclyglycerol synthesis, fatty acid availability and lipid droplet formation. {ECO:0000250|UniProtKB:P56198}.
uniprot
proteins
protein_family
CIDE family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23233732
uniprot
proteins
sequence_length
238
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lipid droplet {ECO:0000250|UniProtKB:P56198}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P56198}. Nucleus {ECO:0000250|UniProtKB:P56198}. Note=Diffuses quickly on lipid droplet surface, but becomes trapped and clustered at lipid droplet contact sites, thereby enabling its rapid enrichment at lipid droplet contact sites. {ECO:0000250|UniProtKB:P56198}.
uniprot
proteins