MAGEA1
entrez
4100
canonical
uniprot
P43355
canonical
ensembl
ENSG00000198681
resolver
ensp
ENSP00000349085
resolver
enst
ENST00000356661
resolver
genesymbol
MAGEA1
resolver
genesymbol_syn
MAGE1
resolver
genesymbol_syn
MAGE1A
resolver
hgnc
HGNC:6796
resolver
uniprot
B2RC81
resolver
uniprot
O00346
resolver
uniprot_entry
MAGA1_HUMAN
resolver
uniprot_sec
B2RC81
resolver
uniprot_sec
O00346
resolver
amino_acid_sequence
MSLEQRSLHCKPEEALEAQQEALGLVCVQAATSSSSPLVLGTLEEVPTAGSTDPPQSPQGASAFPTTINFTRQRQPSEGSSSREEEGPSTSCILESLFRAVITKKVADLVGFLLLKYRAREPVTKAEMLESVIKNYKHCFPEIFGKASESLQLVFGIDVKEADPTGHSYVLVTCLGLSYDGLLGDNQIMPKTGFLIIVLVMIAMEGGHAPEEEIWEELSVMEVYDGREHSAYGEPRKLLTQDLVQEKYLEYRQVPDSDPARYEFLWGPRALAETSYVKVLEYVIKVSARVRFFFPSLREAALREEEEGV
uniprot
proteins
function
FUNCTION: May be involved in transcriptional regulation through interaction with SNW1 and recruiting histone deactelyase HDAC1. May inhibit notch intracellular domain (NICD) transactivation. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. {ECO:0000269|PubMed:15316101}.
uniprot
proteins
mass_dalton
34342
uniprot
proteins
mutagenesis
MUTAGEN 163; /note="D->A: Abolishes HLA-A1 binding."; /evidence="ECO:0000269|PubMed:8113684"; MUTAGEN 169; /note="Y->A: Abolishes HLA-A1 binding."; /evidence="ECO:0000269|PubMed:8113684
uniprot
proteins
pubmed
10854409
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15059299
uniprot
proteins
pubmed
15316101
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15537658
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
1840703
uniprot
proteins
pubmed
19177349
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
7927954
uniprot
proteins
pubmed
8037761
uniprot
proteins
pubmed
8113684
uniprot
proteins
sequence_length
309
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
uniprot
proteins