Gnal
entrez
14680
canonical
uniprot
Q8CGK7
canonical
ensembl
ENSMUSG00000024524
resolver
ensp
ENSMUSP00000025402
resolver
ensp
ENSMUSP00000075908
resolver
ensp
ENSMUSP00000157813
resolver
ensp
ENSMUSP00000158245
resolver
ensp
ENSMUSP00000158520
resolver
ensp
ENSMUSP00000292415
resolver
ensp
ENSMUSP00000292417
resolver
enst
ENSMUST00000025402
resolver
enst
ENSMUST00000076605
resolver
enst
ENSMUST00000236551
resolver
enst
ENSMUST00000236771
resolver
enst
ENSMUST00000237985
resolver
genesymbol
Gnal
resolver
uniprot
A0A494BBI3
resolver
uniprot
F6T3I8
resolver
uniprot
Q3TY78
resolver
uniprot
Q61020
resolver
uniprot
Q61589
resolver
uniprot
Q66L47
resolver
uniprot
Q8BHK8
resolver
uniprot_entry
A0A494BBI3_MOUSE
resolver
uniprot_entry
F6T3I8_MOUSE
resolver
uniprot_entry
GNAL_MOUSE
resolver
uniprot_entry
Q3TY78_MOUSE
resolver
uniprot_entry
Q66L47_MOUSE
resolver
uniprot_entry
Q8BHK8_MOUSE
resolver
uniprot_sec
Q61020
resolver
uniprot_sec
Q61589
resolver
amino_acid_sequence
MGCLGNSSKTAEDQGVDEKERREANKKIEKQLQKERLAYKATHRLLLLGAGESGKSTIVKQMRILHVNGFNPEEKKQKILDIRKNVKDAIVTIVSAMSTIIPPVPLANPENQFRSDYIKSIAPITDFEYSQEFFDHVKKLWDDEGVKACFERSNEYQLIDCAQYFLERIDSVSLVDYTPTDQDLLRCRVLTSGIFETRFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIYVAACSSYNMVIREDNNTNRLRESLDLFESIWNNRWLRTISIILFLNKQDMLAEKVLAGKSKIEDYFPEYANYTVPEDATPDAGEDPKVTRAKFFIRDLFLRISTATGDGKHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLKQYELL
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Guanine nucleotide-binding protein (G protein) involved as transducer in olfactory signal transduction controlled by G protein-coupled receptors (GPCRs) (PubMed:16754875, PubMed:21467038, PubMed:9459443). Contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:21467038). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:21467038). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:21467038). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:21467038). GNAL/G(olf) alpha specifically mediates olfactory signal transduction within the olfactory neuroepithelium and the basal ganglia following GPCRs activation (PubMed:16754875, PubMed:9459443). Acts by promoting the specific activation of adenylyl cyclase ADCY3, resulting in increased levels of the signaling molecule cAMP (By similarity). {ECO:0000250|UniProtKB:P38406, ECO:0000269|PubMed:16754875, ECO:0000269|PubMed:21467038, ECO:0000269|PubMed:9459443}.
uniprot
proteins
mass_dalton
44308
uniprot
proteins
protein_family
G(s) subfamily
uniprot
proteins
protein_family
G-alpha family
uniprot
proteins
pubmed
16754875
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21467038
uniprot
proteins
pubmed
23994616
uniprot
proteins
pubmed
2508088
uniprot
proteins
pubmed
38062020
uniprot
proteins
pubmed
8858601
uniprot
proteins
pubmed
9459443
uniprot
proteins
sequence_length
381
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16754875}; Peripheral membrane protein {ECO:0000269|PubMed:16754875}; Cytoplasmic side {ECO:0000269|PubMed:16754875}. Note=Associated to the plasma membrane via lipid-anchor. {ECO:0000250|UniProtKB:P04896}.
uniprot
proteins