Slc49a4
entrez
224132
canonical
uniprot
Q8BFQ6
canonical
ensembl
ENSMUSG00000022848
resolver
ensp
ENSMUSP00000023554
resolver
enst
ENSMUST00000023554
resolver
genesymbol
Slc49a4
resolver
genesymbol_syn
Dirc2
resolver
uniprot_entry
DIRC2_MOUSE
resolver
amino_acid_sequence
MGSGWSSEEEERQPLLGPGLGPAPGAARRGREATAVLPAAGPNPGRVYGRRWLVLLLFSLLAFAQGLVWNTWGPIQNSARQAYGFSGWDIALLVLWGPIGFLPCFAFMWLLDKRGLRVTVLLTSFLMVLGTGLRCIPVSDLALKKRLIHGGQILNGLAGPTVMNAAPFLSTTWFSADERATATAIASMLSYLGGACAFLVGPLVVPAPNGTAPLLAAESSRAHIKDRIETVLYAEFGVVCLIFSATLAYFPPRPPLPPSVAAASQRLSYRRSFCRLLSNLRFLMIALAYAIPLGVFAGWSGVLDLILTPVHVSQVDAGWIGFWSIVGGCVVGIAMARFADFIRGMLKLILLLLFSGATLSSTWFTLTCLNSITHLPLTTVTLYASCILLGVFLNSSVPIFFELFVETVYPVPEGITCGVVTFLSNMFMGVLLFFVTFYHTELSWFNWCLPGSCLLSLLLILCFRESYDRLYLDVVVSV
uniprot
proteins
function
FUNCTION: Mediates H(+)-dependent pyridoxine transport. {ECO:0000250|UniProtKB:Q96SL1}.
uniprot
proteins
mass_dalton
51909
uniprot
proteins
post_translational_modification
PTM: Cleaved in lysosomes by cathepsin L between Leu-214 and Ala-261, generating a N-glycosylated N-terminal and a non-glycosylated C-terminal fragment. {ECO:0000250|UniProtKB:Q96SL1}.
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
478
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q96SL1}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 52..72; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 90..110; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 118..138; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 153..173; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 185..205; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 230..250; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 282..302; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 315..335; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 348..368; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 385..405; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 415..435; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 443..463; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins