Klrk1
entrez
24934
canonical
uniprot
O70215
canonical
ensembl
ENSRNOG00000061739
resolver
ensp
ENSRNOP00000071035
resolver
ensp
ENSRNOP00000110632
resolver
enst
ENSRNOT00000091890
resolver
enst
ENSRNOT00000146938
resolver
genesymbol
Klrk1
resolver
genesymbol_syn
Nkg2d
resolver
genesymbol_syn
Nkrp2
resolver
uniprot
A0A0G2JZG3
resolver
uniprot
A0ABK0M5F8
resolver
uniprot_entry
A0A0G2JZG3_RAT
resolver
uniprot_entry
A0ABK0M5F8_RAT
resolver
uniprot_entry
NKG2D_RAT
resolver
amino_acid_sequence
MSKCHNYDLKPAKWDTSQEHQKQRSALPTSRPGENGIIRRRSSIEELKISPLFVVRVLVAAMTIRFTVITLTWLAVFITLLCNKEVSVSSREGYCGPCPNDWICHRNNCYQFFNENKAWNQSQASCLSQNSSLLKIYSKEEQDFLKLVKSYHWMGLVQSPANGSWQWEDGSSLSPNELTLVKTPSGTCAVYGSSFKAYTEDCSNPNTYICMKRAV
uniprot
proteins
function
FUNCTION: Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins. {ECO:0000269|PubMed:15048723}.
uniprot
proteins
mass_dalton
24438
uniprot
proteins
pubmed
15048723
uniprot
proteins
pubmed
9620593
uniprot
proteins
sequence_length
215
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Colocalized with HCST on the cell surface. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 52..74; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins