Antxr1
entrez
362393
canonical
uniprot
Q0PMD2
canonical
ensembl
ENSRNOG00000008678
resolver
ensp
ENSRNOP00000011675
resolver
enst
ENSRNOT00000011675
resolver
genesymbol
Antxr1
resolver
uniprot
A0A0G2JSJ5
resolver
uniprot_entry
A0A0G2JSJ5_RAT
resolver
uniprot_entry
ANTR1_RAT
resolver
amino_acid_sequence
MDRAGRLGTGLRGLCVAALVLVCAGQGGRREDGGPACYGGFDLYFILDKSGSVLHHWNEIYYFVEQLAHRFISPQLRMSFIVFSTRGTTLMKLTEDREQIRQGLEELQKVLPGGDTYMHEGFERASEQIYYENSQGYRTASVIIALTDGELHEDLFFYSEREANRSRDLGAIVYCVGVKDFNETQLARIADSKDHVFPVNDGFQALQGIIHSILKKSCIEILAAEPSTICAGESFQVVVRGNGFRHARNVDRVLCSFKINDSVTLNEKPFAVEDTYLLCPAPILKEVGMKAALQVSMNDGLSFISSSVIITTTHCSDGSILAIALLILFLLLALALLWWFWPLCCTVIIKEVPPPPVEESEEEDDDGLPKKKWPTVDASYYGGRGVGGIKRMEVRWGEKGSTEEGAKLEKAKNARVKMPEQEYEFPEPRNLNNNMRRPSSPRKWYSPIKGKLDALWVLLRKGYDRVSVMRPQPGDTGRCINFTRVKNSQPAKYPLNNSYHSSSPPPAPIYTPPPPAPHCPPPAPSAPTPPIPSPPSTLPPPPQAPPPNRAPPPSRPPPRPSV
uniprot
proteins
function
FUNCTION: Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton and thereby plays an important role in normal extracellular matrix (ECM) homeostasis. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. May also act as a receptor for PLAU. Upon ligand binding, stimulates the phosphorylation of EGFR and ERK1/2. {ECO:0000250|UniProtKB:Q9H6X2}.
uniprot
proteins
mass_dalton
62319
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:Q9H6X2}.; PTM: Phosphorylated upon PLAU binding. {ECO:0000250|UniProtKB:Q9H6X2}.
uniprot
proteins
protein_family
ATR family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
562
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9H6X2}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9H6X2}. Cell projection, lamellipodium membrane {ECO:0000250|UniProtKB:Q9H6X2}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9H6X2}. Cell projection, filopodium membrane {ECO:0000250|UniProtKB:Q9H6X2}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9H6X2}. Note=At the membrane of lamellipodia and at the tip of actin-enriched filopodia. Colocalizes with actin at the base of lamellipodia. {ECO:0000250|UniProtKB:Q9H6X2}.
uniprot
proteins
transmembrane_region
TRANSMEM 320..340; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins