ILF2
entrez
3608
canonical
uniprot
Q12905
canonical
ensembl
ENSG00000143621
resolver
ensp
ENSP00000355011
resolver
ensp
ENSP00000482909
resolver
enst
ENST00000361891
resolver
enst
ENST00000615950
resolver
genesymbol
ILF2
resolver
genesymbol_syn
NF45
resolver
hgnc
HGNC:6037
resolver
uniprot
A0A087WZV2
resolver
uniprot
A6NDB0
resolver
uniprot
B2R8G7
resolver
uniprot
B4DY09
resolver
uniprot
F4ZW62
resolver
uniprot
Q53FG3
resolver
uniprot
Q5SR10
resolver
uniprot
Q5SR11
resolver
uniprot
Q7L7R3
resolver
uniprot
Q9BWD4
resolver
uniprot
Q9P1N0
resolver
uniprot_entry
A0A087WZV2_HUMAN
resolver
uniprot_entry
B4DY09_HUMAN
resolver
uniprot_entry
F4ZW62_HUMAN
resolver
uniprot_entry
ILF2_HUMAN
resolver
uniprot_entry
Q53FG3_HUMAN
resolver
uniprot_sec
A6NDB0
resolver
uniprot_sec
B2R8G7
resolver
uniprot_sec
Q5SR10
resolver
uniprot_sec
Q5SR11
resolver
uniprot_sec
Q7L7R3
resolver
uniprot_sec
Q9BWD4
resolver
uniprot_sec
Q9P1N0
resolver
amino_acid_sequence
MRGDRGRGRGGRFGSRGGPGGGFRPFVPHIPFDFYLCEMAFPRVKPAPDETSFSEALLKRNQDLAPNSAEQASILSLVTKINNVIDNLIVAPGTFEVQIEEVRQVGSYKKGTMTTGHNVADLVVILKILPTLEAVAALGNKVVESLRAQDPSEVLTMLTNETGFEISSSDATVKILITTVPPNLRKLDPELHLDIKVLQSALAAIRHARWFEENASQSTVKVLIRLLKDLRIRFPGFEPLTPWILDLLGHYAVMNNPTRQPLALNVAYRRCLQILAAGLFLPGSVGITDPCESGNFRVHTVMTLEQQDMVCYTAQTLVRILSHGGFRKILGQEGDASYLASEISTWDGVIVTPSEKAYEKPPEKKEGEEEEENTEEPPQGEEEESMETQE
uniprot
proteins
function
FUNCTION: Chromatin-interacting protein that forms a stable heterodimer with interleukin enhancer-binding factor 3/ILF3 and plays a role in several biological processes including transcription, innate immunity or cell growth (PubMed:18458058, PubMed:31212927). Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus. Together with ILF3, forms an RNA-binding complex that is required for mitotic progression and cytokinesis by regulating the expression of a cluster of mitotic genes. Mechanistically, competes with STAU1/STAU2-mediated mRNA decay (PubMed:32433969). Also plays a role in the inhibition of various viruses including Japanese encephalitis virus or enterovirus 71. {ECO:0000269|PubMed:10574923, ECO:0000269|PubMed:11739746, ECO:0000269|PubMed:18458058, ECO:0000269|PubMed:21123651, ECO:0000269|PubMed:31212927, ECO:0000269|PubMed:32433969, ECO:0000269|PubMed:9442054}.; FUNCTION: (Microbial infection) Plays a positive role in HIV-1 virus production by binding to and thereby stabilizing HIV-1 RNA, together with ILF3. {ECO:0000269|PubMed:26891316}.
uniprot
proteins
mass_dalton
43062
uniprot
proteins
mutagenesis
MUTAGEN 45; /note="K->R: Completely abolishes the effect of CRBN on ILF2."; /evidence="ECO:0000269|PubMed:33009960
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated at Lys-45 by CRBN with polyubiquitin chains by the CUL4-RING E3 ligase (CRL4-CRBN) and then degraded by the proteasome. {ECO:0000269|PubMed:33009960}.
uniprot
proteins
pubmed
10574923
uniprot
proteins
pubmed
11739746
uniprot
proteins
pubmed
11790298
uniprot
proteins
pubmed
12429849
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17289661
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
17890166
uniprot
proteins
pubmed
18458058
uniprot
proteins
pubmed
21123651
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26891316
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
31212927
uniprot
proteins
pubmed
31878072
uniprot
proteins
pubmed
32433969
uniprot
proteins
pubmed
33009960
uniprot
proteins
pubmed
7519613
uniprot
proteins
pubmed
9442054
uniprot
proteins
sequence_length
390
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus. Cytoplasm {ECO:0000269|PubMed:31212927, ECO:0000269|PubMed:31878072}. Nucleus {ECO:0000269|PubMed:31878072}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
uniprot
proteins