Emc3
entrez
66087
canonical
uniprot
Q99KI3
canonical
ensembl
ENSMUSG00000030286
resolver
ensp
ENSMUSP00000032425
resolver
enst
ENSMUST00000032425
resolver
genesymbol
Emc3
resolver
genesymbol_syn
Tmem111
resolver
uniprot
Q3TIK3
resolver
uniprot_entry
EMC3_MOUSE
resolver
uniprot_sec
Q3TIK3
resolver
amino_acid_sequence
MAGPELLLDSNIRLWVVLPIVIITFFVGMIRHYVSILLQSDKKLTQEQVSDSQVLIRSRVLRENGKYIPKQSFLTRKYYFNNPEDGFFKKTKRKVVPPSPMTDPTMLTDMMKGNVTNVLPMILIGGWINMTFSGFVTTKVPFPLTLRFKPMLQQGIELLTLDASWVSSASWYFLNVFGLRSIYSLILGQDNAADQSRMMQEQMTGAAMAMPADTNKAFKTEWEALELTDHQWALDDVEEELMARDLHFEGMFKKELQTSIF
uniprot
proteins
function
FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. {ECO:0000250|UniProtKB:Q9P0I2}.
uniprot
proteins
mass_dalton
29980
uniprot
proteins
protein_family
EMC3 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
261
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9P0I2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9P0I2}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..38; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9P0I2"; TRANSMEM 115..130; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9P0I2"; TRANSMEM 169..187; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9P0I2
uniprot
proteins