TNRC6A
entrez
27327
canonical
uniprot
Q8NDV7
canonical
ensembl
ENSG00000090905
resolver
ensp
ENSP00000326900
resolver
ensp
ENSP00000379144
resolver
ensp
ENSP00000565526
resolver
ensp
ENSP00000608540
resolver
ensp
ENSP00000608541
resolver
ensp
ENSP00000608542
resolver
ensp
ENSP00000608544
resolver
genesymbol
TNRC6A
resolver
genesymbol_syn
CAGH26
resolver
genesymbol_syn
KIAA1460
resolver
genesymbol_syn
TNRC6
resolver
hgnc
HGNC:11969
resolver
uniprot
C9JAR8
resolver
uniprot
O15408
resolver
uniprot
Q658L5
resolver
uniprot
Q6NVB5
resolver
uniprot
Q8NEZ0
resolver
uniprot
Q8TBT8
resolver
uniprot
Q8TCR0
resolver
uniprot
Q9NV59
resolver
uniprot
Q9P268
resolver
uniprot_entry
TNR6A_HUMAN
resolver
uniprot_sec
C9JAR8
resolver
uniprot_sec
O15408
resolver
uniprot_sec
Q658L5
resolver
uniprot_sec
Q6NVB5
resolver
uniprot_sec
Q8NEZ0
resolver
uniprot_sec
Q8TBT8
resolver
uniprot_sec
Q8TCR0
resolver
uniprot_sec
Q9NV59
resolver
uniprot_sec
Q9P268
resolver
amino_acid_sequence
MRELEAKATKDVERNLSRDLVQEEEQLMEEKKKKKDDKKKKEAAQKKATEQKIKVPEQIKPSVSQPQPANSNNGTSTATSTNNNAKRATANNQQPQQQQQQQQPQQQQPQQQPQPQPQQQQPQQQPQALPRYPREVPPRFRHQEHKQLLKRGQHFPVIAANLGSAVKVLNSQSESSALTNQQPQNNGEVQNSKNQSDINHSTSGSHYENSQRGPVSSTSDSSTNCKNAVVSDLSEKEAWPSAPGSDPELASECMDADSASSSESERNITIMASGNTGGEKDGLRNSTGLGSQNKFVVGSSSNNVGHGSSTGPWGFSHGAIISTCQVSVDAPESKSESSNNRMNAWGTVSSSSNGGLNPSTLNSASNHGAWPVLENNGLALKGPVGSGSSGINIQCSTIGQMPNNQSINSKVSGGSTHGTWGSLQETCESEVSGTQKVSFSGQPQNITTEMTGPNNTTNFMTSSLPNSGSVQNNELPSSNTGAWRVSTMNHPQMQAPSGMNGTSLSHLSNGESKSGGSYGTTWGAYGSNYSGDKCSGPNGQANGDTVNATLMQPGVNGPMGTNFQVNTNKGGGVWESGAANSQSTSWGSGNGANSGGSRRGWGTPAQNTGTNLPSVEWNKLPSNQHSNDSANGNGKTFTNGWKSTEEEDQGSATSQTNEQSSVWAKTGGTVESDGSTESTGRLEEKGTGESQSRDRRKIDQHTLLQSIVNRTDLDPRVLSNSGWGQTPIKQNTAWDTETSPRGERKTDNGTEAWGSSATQTFNSGACIDKTSPNGNDTSSVSGWGDPKPALRWGDSKGSNCQGGWEDDSAATGMVKSNQWGNCKEEKAAWNDSQKNKQGWGDGQKSSQGWSVSASDNWGETSRNNHWGEANKKSSSGGSDSDRSVSGWNELGKTSSFTWGNNINPNNSSGWDESSKPTPSQGWGDPPKSNQSLGWGDSSKPVSSPDWNKQQDIVGSWGIPPATGKPPGTGWLGGPIPAPAKEEEPTGWEEPSPESIRRKMEIDDGTSAWGDPSKYNYKNVNMWNKNVPNGNSRSDQQAQVHQLLTPASAISNKEASSGSGWGEPWGEPSTPATTVDNGTSAWGKPIDSGPSWGEPIAAASSTSTWGSSSVGPQALSKSGPKSMQDGWCGDDMPLPGNRPTGWEEEEDVEIGMWNSNSSQELNSSLNWPPYTKKMSSKGLSGKKRRRERGMMKGGNKQEEAWINPFVKQFSNISFSRDSPEENVQSNKMDLSGGMLQDKRMEIDKHSLNIGDYNRTVGKGPGSRPQISKESSMERNPYFDKDGIVADESQNMQFMSSQSMKLPPSNSALPNQALGSIAGLGMQNLNSVRQNGNPSMFGVGNTAAQPRGMQQPPAQPLSSSQPNLRAQVPPPLLSPQVPVSLLKYAPNNGGLNPLFGPQQVAMLNQLSQLNQLSQISQLQRLLAQQQRAQSQRSVPSGNRPQQDQQGRPLSVQQQMMQQSRQLDPNLLVKQQTPPSQQQPLHQPAMKSFLDNVMPHTTPELQKGPSPINAFSNFPIGLNSNLNVNMDMNSIKEPQSRLRKWTTVDSISVNTSLDQNSSKHGAISSGFRLEESPFVPYDFMNSSTSPASPPGSIGDGWPRAKSPNGSSSVNWPPEFRPGEPWKGYPNIDPETDPYVTPGSVINNLSINTVREVDHLRDRNSGSSSSLNTTLPSTSAWSSIRASNYNVPLSSTAQSTSARNSDSKLTWSPGSVTNTSLAHELWKVPLPPKNITAPSRPPPGLTGQKPPLSTWDNSPLRIGGGWGNSDARYTPGSSWGESSSGRITNWLVLKNLTPQIDGSTLRTLCMQHGPLITFHLNLPHGNALVRYSSKEEVVKAQKSLHMCVLGNTTILAEFASEEEISRFFAQSQSLTPSPGWQSLGSSQSRLGSLDCSHSFSSRTDLNHWNGAGLSGTNCGDLHGTSLWGTPHYSTSLWGPPSSSDPRGISSPSPINAFLSVDHLGGGGESM
uniprot
proteins
disease_involvement
DISEASE: Epilepsy, familial adult myoclonic, 6 (FAME6) [MIM:618074]: A form of familial myoclonic epilepsy, a neurologic disorder characterized by cortical hand tremors, myoclonic jerks and occasional generalized or focal seizures with a non-progressive or very slowly progressive disease course. Usually, myoclonic tremor is the presenting symptom, characterized by tremulous finger movements and myoclonic jerks of the limbs increased by action and posture. In a minority of patients, seizures are the presenting symptom. Some patients exhibit mild cognitive impairment. FAME6 inheritance is autosomal dominant. {ECO:0000269|PubMed:29507423}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:16284622, ECO:0000269|PubMed:16284623, ECO:0000269|PubMed:17596515, ECO:0000269|PubMed:17671087, ECO:0000269|PubMed:19056672, ECO:0000269|PubMed:19304925}.
uniprot
proteins
mass_dalton
210297
uniprot
proteins
mutagenesis
MUTAGEN 313; /note="W->A: Does not impair interaction with AGO2; when associated with A-345; A-370; A-420 and A-483."; /evidence="ECO:0000269|PubMed:19324964"; MUTAGEN 345; /note="W->A: Does not impair interaction with AGO2; when associated with A-313; A-370; A-420 and A-483."; /evidence="ECO:0000269|PubMed:19324964"; MUTAGEN 370; /note="W->A: Does not impair interaction with AGO2; when associated with A-313; A-345; A-420 and A-483."; /evidence="ECO:0000269|PubMed:19324964"; MUTAGEN 420; /note="W->A: Does not impair interaction with AGO2; when associated with A-313; A-345; A-370 and A-483."; /evidence="ECO:0000269|PubMed:19324964"; MUTAGEN 483; /note="W->A: Does not impair interaction with AGO2; when associated with A-313; A-345; A-370 and A-420."; /evidence="ECO:0000269|PubMed:19324964
uniprot
proteins
protein_family
GW182 family
uniprot
proteins
pubmed
10819331
uniprot
proteins
pubmed
11950943
uniprot
proteins
pubmed
13130130
uniprot
proteins
pubmed
14598044
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15494374
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
15908945
uniprot
proteins
pubmed
16284622
uniprot
proteins
pubmed
16284623
uniprot
proteins
pubmed
16906129
uniprot
proteins
pubmed
17596515
uniprot
proteins
pubmed
17671087
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18690212
uniprot
proteins
pubmed
18946079
uniprot
proteins
pubmed
19056672
uniprot
proteins
pubmed
19304925
uniprot
proteins
pubmed
19324964
uniprot
proteins
pubmed
19383768
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21981923
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26134560
uniprot
proteins
pubmed
28546213
uniprot
proteins
pubmed
29395067
uniprot
proteins
pubmed
29507423
uniprot
proteins
pubmed
31400113
uniprot
proteins
pubmed
9225980
uniprot
proteins
sequence_length
1962
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:11950943, ECO:0000269|PubMed:13130130, ECO:0000269|PubMed:15494374, ECO:0000269|PubMed:15908945, ECO:0000269|PubMed:16284622, ECO:0000269|PubMed:16284623, ECO:0000269|PubMed:16906129, ECO:0000269|PubMed:18946079, ECO:0000269|PubMed:19056672, ECO:0000269|PubMed:19324964, ECO:0000269|PubMed:31400113}. Note=Mammalian P-bodies are also known as GW bodies (GWBs). {ECO:0000305}.
uniprot
proteins