NPPC
entrez
4880
canonical
uniprot
P23582
canonical
ensembl
ENSG00000163273
resolver
ensp
ENSP00000295440
resolver
ensp
ENSP00000387159
resolver
ensp
ENSP00000638107
resolver
ensp
ENSP00000638108
resolver
ensp
ENSP00000638109
resolver
enst
ENST00000295440
resolver
enst
ENST00000409852
resolver
enst
ENST00000968048
resolver
enst
ENST00000968049
resolver
enst
ENST00000968050
resolver
genesymbol
NPPC
resolver
genesymbol_syn
CNP2
resolver
hgnc
HGNC:7941
resolver
uniprot
E5LCN7
resolver
uniprot
Q4ZG41
resolver
uniprot_entry
ANFC_HUMAN
resolver
uniprot_entry
E5LCN7_HUMAN
resolver
uniprot_sec
Q4ZG41
resolver
amino_acid_sequence
MHLSQLLACALLLTLLSLRPSEAKPGAPPKVPRTPPAEELAEPQAAGGGQKKGDKAPGGGGANLKGDRSRLLRDLRVDTKSRAAWARLLQEHPNARKYKGANKKGLSKGCFGLKLDRIGSMSGLGC
uniprot
proteins
function
FUNCTION: [CNP-22]: Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation (By similarity). May also be vasoactive and natriuretic (PubMed:1672777). Acts by specifically binding and stimulating NPR2 to produce cGMP (PubMed:1672777, PubMed:21098034). Binds the clearance receptor NPR3 (PubMed:11533490). {ECO:0000250|UniProtKB:Q61839, ECO:0000269|PubMed:11533490, ECO:0000269|PubMed:1672777, ECO:0000269|PubMed:21098034}.
uniprot
proteins
mass_dalton
13246
uniprot
proteins
post_translational_modification
PTM: [CNP-22]: Degraded by IDE (in vitro). {ECO:0000269|PubMed:21098034}.
uniprot
proteins
protein_family
Natriuretic peptide family
uniprot
proteins
pubmed
11533490
uniprot
proteins
pubmed
1339402
uniprot
proteins
pubmed
1472040
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
1672777
uniprot
proteins
pubmed
2018508
uniprot
proteins
pubmed
21098034
uniprot
proteins
pubmed
29941213
uniprot
proteins
pubmed
9794555
uniprot
proteins
sequence_length
126
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins