STOM
entrez
2040
canonical
uniprot
P27105
canonical
ensembl
ENSG00000148175
resolver
ensp
ENSP00000286713
resolver
ensp
ENSP00000339607
resolver
ensp
ENSP00000445764
resolver
ensp
ENSP00000716988
resolver
enst
ENST00000538954
resolver
genesymbol
STOM
resolver
genesymbol_syn
BND7
resolver
genesymbol_syn
EPB72
resolver
hgnc
HGNC:3383
resolver
uniprot
B1AM77
resolver
uniprot
F8VSL7
resolver
uniprot
Q14087
resolver
uniprot
Q15609
resolver
uniprot
Q5VX96
resolver
uniprot
Q96FK4
resolver
uniprot_entry
F8VSL7_HUMAN
resolver
uniprot_entry
STOM_HUMAN
resolver
uniprot_sec
B1AM77
resolver
uniprot_sec
Q14087
resolver
uniprot_sec
Q15609
resolver
uniprot_sec
Q5VX96
resolver
uniprot_sec
Q96FK4
resolver
amino_acid_sequence
MAEKRHTRDSEAQRLPDSFKDSPSKGLGPCGWILVAFSFLFTVITFPISIWMCIKIIKEYERAIIFRLGRILQGGAKGPGLFFILPCTDSFIKVDMRTISFDIPPQEILTKDSVTISVDGVVYYRVQNATLAVANITNADSATRLLAQTTLRNVLGTKNLSQILSDREEIAHNMQSTLDDATDAWGIKVERVEIKDVKLPVQLQRAMAAEAEASREARAKVIAAEGEMNASRALKEASMVITESPAALQLRYLQTLTTIAAEKNSTIVFPLPIDMLQGIIGAKHSHLG
uniprot
proteins
function
FUNCTION: Regulates ion channel activity and transmembrane ion transport. Regulates ASIC2 and ASIC3 channel activity.
uniprot
proteins
mass_dalton
31731
uniprot
proteins
mutagenesis
MUTAGEN 182; /note="T->A: No effect on oligomerization."; /evidence="ECO:0000269|PubMed:16766530"; MUTAGEN 185; /note="W->A: Complete loss of oligomerization."; /evidence="ECO:0000269|PubMed:16766530"; MUTAGEN 252; /note="Y->A: Complete loss of oligomerization."; /evidence="ECO:0000269|PubMed:16766530"; MUTAGEN 263; /note="K->A: Reduced oligomerization and lipid raft association."; MUTAGEN 264; /note="N->A: Reduced oligomerization and lipid raft association."; MUTAGEN 265; /note="S->A: Oligomerization reduced to 18%. Reduced lipid raft association."; MUTAGEN 266; /note="T->A: Complete loss of oligomerization. Reduced lipid raft association."; MUTAGEN 267; /note="I->A: Complete loss of oligomerization and lipid raft association."; MUTAGEN 268; /note="V->A: Complete loss of oligomerization and lipid raft association."; MUTAGEN 269; /note="F->A: Complete loss of oligomerization and lipid raft association."; MUTAGEN 270; /note="P->A: Complete loss of oligomerization. No effect on lipid raft association."; MUTAGEN 271; /note="L->A: Complete loss of oligomerization. Reduced lipid raft association."; MUTAGEN 272; /note="P->A: Oligomerization reduced to 18%. Reduced lipid raft association."; MUTAGEN 273; /note="I->A: Complete loss of oligomerization. Reduced lipid raft association."; MUTAGEN 274; /note="D->A: Reduced oligomerization and lipid raft association."; MUTAGEN 275; /note="M->A: Reduced oligomerization and lipid raft association."; MUTAGEN 276; /note="L->A: Reduced oligomerization and lipid raft association.
uniprot
proteins
protein_family
Band 7/mec-2 family
uniprot
proteins
pubmed
10338112
uniprot
proteins
pubmed
12130500
uniprot
proteins
pubmed
12643545
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
1547348
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16766530
uniprot
proteins
pubmed
17081065
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
1883838
uniprot
proteins
pubmed
19696025
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23219802
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28387307
uniprot
proteins
pubmed
7592848
uniprot
proteins
pubmed
8373790
uniprot
proteins
pubmed
8825639
uniprot
proteins
pubmed
9243190
uniprot
proteins
pubmed
9512664
uniprot
proteins
pubmed
9642292
uniprot
proteins
sequence_length
288
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9243190}; Peripheral membrane protein {ECO:0000269|PubMed:9243190}; Cytoplasmic side {ECO:0000269|PubMed:9243190}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9243190}. Cell membrane {ECO:0000269|PubMed:12130500}; Lipid-anchor {ECO:0000269|PubMed:12130500}; Cytoplasmic side {ECO:0000269|PubMed:12130500}. Membrane raft {ECO:0000269|PubMed:12130500, ECO:0000269|PubMed:23219802}. Melanosome {ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:17081065}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:P54116}. Note=Localizes to juxtanuclear structure probably derived from the Golgi apparatus (PubMed:9243190). Colocalizes with cortical actin microfilaments at small plasma membrane protrusions (PubMed:9243190). Associates with alpha-granular lipid rafts (PubMed:12130500). Translocates from the alpha-granular lipid rafts to the cell membrane on thrombin activation and selectively enriched in released microvesicles (PubMed:12130500). Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:12643545). {ECO:0000269|PubMed:12130500, ECO:0000269|PubMed:12643545, ECO:0000269|PubMed:9243190}.
uniprot
proteins