Hat1
entrez
296501
canonical
uniprot
Q5M939
canonical
ensembl
ENSRNOG00000001524
resolver
ensembl
ENSRNOG00055024452
resolver
ensembl
ENSRNOG00060002497
resolver
ensembl
ENSRNOG00065017010
resolver
ensp
ENSRNOP00000002085
resolver
ensp
ENSRNOP00000079274
resolver
ensp
ENSRNOP00055034309
resolver
ensp
ENSRNOP00060002829
resolver
ensp
ENSRNOP00065022452
resolver
enst
ENSRNOT00000002085
resolver
enst
ENSRNOT00000117911
resolver
enst
ENSRNOT00055042075
resolver
enst
ENSRNOT00060004005
resolver
enst
ENSRNOT00065028392
resolver
genesymbol
Hat1
resolver
uniprot
A0A8I5ZN33
resolver
uniprot_entry
A0A8I5ZN33_RAT
resolver
uniprot_entry
HAT1_RAT
resolver
amino_acid_sequence
MAGFGAMEKFLVEYKSAVEKKLAEYKCNTNTAIELKLVRFPEDLENDIRTFFPEYTHQLFGDDETAFGYKGLKILLYYIAGSLSTMFRVEYASKVDENFDCVEADDVEGKIRQIIPPGFCTNTNDFLSLLEKEADFKPFGTLLHTYSVPSPTGGENFTFQIYKADMTCRGFREYHERLQTFLMWFIETASFIDVDDERWHYFLVFEKYNKDGATLFATVGYMTVYNYYVYPDKTRPRVSQMLILTPFQGQGHGAQLLETVHRYYIASSSVLDITAEDPSKSYVKLRDFVLVKLCQDLPCFSRERLLQGFNEDMAIQAQQKFKINKQHARRVYEILRLLVTDMSDAEQCRSYRLDIKRRLISPYKKKQTDLAKMRKCLRPEELTNQMNQIEISVQHEQLEEQFQELVEDYRRVIERLAQE
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
ec_number
2.3.1.48
uniprot
proteins
function
FUNCTION: Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac). Drives H4 production by chromatin binding to support chromatin replication and acetylation. Since transcription of H4 genes is tightly coupled to S-phase, plays an important role in S-phase entry and progression. Promotes homologous recombination in DNA repair by facilitating histone turnover and incorporation of acetylated H3.3 at sites of double-strand breaks. In addition, acetylates other substrates such as chromatin-related proteins. Also acetylates RSAD2 which mediates the interaction of ubiquitin ligase UBE4A with RSAD2 leading to RSAD2 ubiquitination and subsequent degradation. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-methylpropenoyl-CoA (methacryl-CoA), and is able to mediate histone methacrylation. {ECO:0000250|UniProtKB:O14929}.
uniprot
proteins
mass_dalton
49241
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by AMPK at Ser-190; phosphorylation increases HAT1 activity. {ECO:0000250|UniProtKB:O14929}.
uniprot
proteins
protein_family
HAT1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
419
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000250|UniProtKB:O14929}. Mitochondrion {ECO:0000250|UniProtKB:O14929}.
uniprot
proteins