E2f8
entrez
108961
canonical
uniprot
Q58FA4
canonical
ensembl
ENSMUSG00000046179
resolver
ensp
ENSMUSP00000056778
resolver
ensp
ENSMUSP00000112883
resolver
enst
ENSMUST00000058745
resolver
enst
ENSMUST00000119223
resolver
genesymbol
E2f8
resolver
uniprot
Q3U4W2
resolver
uniprot
Q497V7
resolver
uniprot
Q5PRE4
resolver
uniprot
Q8BQJ5
resolver
uniprot
Q8C3Y5
resolver
uniprot_entry
E2F8_MOUSE
resolver
uniprot_sec
Q3U4W2
resolver
uniprot_sec
Q497V7
resolver
uniprot_sec
Q5PRE4
resolver
uniprot_sec
Q8BQJ5
resolver
uniprot_sec
Q8C3Y5
resolver
amino_acid_sequence
MENQKENLFSEPHKRGLMKSPLHPSSKANMVLAEIQPDLGPLTTPTKPKEVSQGEPWTPTANLKMLISAVSPEIRSRDQKRGLSDNRSALPEARDCLHEHLSGDEFEKSQPSRKEKSLGLLCHKFLARYPKYPNPAVNNDICLDEVAEELNVERRRIYDIVNVLESLHMVSRLAKNRYTWHGRHNLTKTLGTLKSVGEENKYAEQIMMIKRKEYEQEFDFIKSCGIEDHVIKSHTGQNGHSDMCFVELPGVEFRAASVNSRKDKSLRVMSQKFVMLFLVSTPQIVSLEIAAKILIGEDHVEDLDKSKYKTKIRRLYDIANVLSSLDLIKKVHVTEERGRKPAFKWTGPEISPNNSGSSPIMPLPASLEAEQSAKENCAKNLFSTRGKPSFTRHPSLIKLVKSIENDRRKISSAPSSPVKSNKAESSQNSPPVPNKMAQLAAICKMQLEEQSSEPRKKVKVNLARSGHYKPLAPLDPTVNTELELLTPSLIQPLGVVPLIPSPLSSAVPVILPQAPSGPSYAIYLQPAQAQMLTPPPGLSPTVCPTQPSNATGSKDPTDAPAEKTATDAATTGSLQPAPERHGAKHRSKETTGDRGTKRMITAEDSGPSSVKKPKEDLKALENVPTPTPLFPSGYLIPLTQCSSLGPDSVLSNTENSGTPSPNHRIYGSPIAGVIPVASSELTAVNFPPFHVTPLKLMVSPTSMAAVPVGNSPALNSGHPAPAQNPSSAIVNFTLQHLGLISPGVQMSASPGPGAGTVPVSPRVEADNLSSRQRRATNHDSPVLGQSQLNGQPVAGTGAQQPVPVTPKGSQLVAENFFRTPGGPTKPTSSPYTDFDGANKTSFGTLFVPQRKLEVSTEDIH
uniprot
proteins
function
FUNCTION: Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. {ECO:0000269|PubMed:18194653, ECO:0000269|PubMed:22516201, ECO:0000269|PubMed:22903062, ECO:0000269|PubMed:23064264, ECO:0000269|PubMed:23064266}.
uniprot
proteins
mass_dalton
93276
uniprot
proteins
mutagenesis
MUTAGEN 118..119; /note="LG->EF: Loss of DNA-binding."; /evidence="ECO:0000269|PubMed:15722552"; MUTAGEN 266..267; /note="LR->EF: Loss of DNA-binding."; /evidence="ECO:0000269|PubMed:15722552
uniprot
proteins
protein_family
E2F/DP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15722552
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18194653
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22516201
uniprot
proteins
pubmed
22903062
uniprot
proteins
pubmed
23064264
uniprot
proteins
pubmed
23064266
uniprot
proteins
sequence_length
860
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15722552}.
uniprot
proteins