TRABD2B
entrez
388630
canonical
uniprot
A6NFA1
canonical
ensembl
ENSG00000269113
resolver
ensp
ENSP00000476820
resolver
ensp
ENSP00000548731
resolver
ensp
ENSP00000548732
resolver
ensp
ENSP00000548733
resolver
ensp
ENSP00000783897
resolver
ensp
ENSP00000783898
resolver
enst
ENST00000606738
resolver
genesymbol
TRABD2B
resolver
genesymbol_syn
HKAT
resolver
genesymbol_syn
TIKI2
resolver
hgnc
HGNC:44200
resolver
uniprot
I6U4Y0
resolver
uniprot_entry
TIKI2_HUMAN
resolver
uniprot_sec
I6U4Y0
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by 1,10-phenanthroline, a metalloprotease inhibitor which is a divalent metal chelator. Also inhibited by EDTA. Not inhibited by Bestatin, an aminopeptidase inhibitor, nor to a mixture of inhibitors for serine, cysteine, and aspartic proteases and aminopeptidases. {ECO:0000269|PubMed:22726442}.
uniprot
proteins
amino_acid_sequence
MHAALAGPLLAALLATARARPQPPDGGQCRPPGSQRDLNSFLWTIRRDPPAYLFGTIHVPYTRVWDFIPDNSKAAFQASTRVYFELDLTDPYTISALASCQLLPHGENLQDVLPHELYWRLKRHLDYVKLMMPSWMTPAQRGKGLYADYLFNAIAGNWERKRPVWVMLMVNSLTERDVRFRGVPVLDLYLAQQAEKMKKTTGAVEQVEEQCHPLNNGLNFSQVLFALNQTLLQQESVRAGSLQASYTTEDLIKHYNCGDLSAVIFNHDTSQLPNFINTTLPPHEQVTAQEIDSYFRQELIYKRNERMGKRVMALLRENEDKICFFAFGAGHFLGNNTVIDILRQAGLEVDHTPAGQAIHSPAPQSPAPSPEGTSTSPAPVTPAAAVPEAPSVTPTAPPEDEDPALSPHLLLPDSLSQLEEFGRQRKWHKRQSTHQRPRQFNDLWVRIEDSTTASPPPLPLQPTHSSGTAKPPFQLSDQLQQQDPPGPASSSAPTLGLLPAIATTIAVCFLLHSLGPS
uniprot
proteins
ec_number
3.4.-.-
uniprot
proteins
function
FUNCTION: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. {ECO:0000269|PubMed:22726442, ECO:0000269|PubMed:35182431}.
uniprot
proteins
mass_dalton
57421
uniprot
proteins
post_translational_modification
PTM: Attached to the external leaflet of the plasma membrane and enriched in membrane rafts via a GPI anchor. The GPI anchor can be cleaved by GDPD4/GDE6 and GDPD2/GDE3, releasing the protein from membranes. {ECO:0000269|PubMed:35182431}.
uniprot
proteins
protein_family
TIKI family
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
22726442
uniprot
proteins
pubmed
35182431
uniprot
proteins
sequence_length
517
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22726442, ECO:0000269|PubMed:35182431}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:35182431}. Membrane raft {ECO:0000269|PubMed:35182431}.
uniprot
proteins