Foxi3
entrez
232077
canonical
uniprot
D3Z120
canonical
ensembl
ENSMUSG00000055874
resolver
ensp
ENSMUSP00000065664
resolver
ensp
ENSMUSP00000125380
resolver
enst
ENSMUST00000069634
resolver
genesymbol
Foxi3
resolver
uniprot
E0CZH3
resolver
uniprot_entry
FOXI3_MOUSE
resolver
uniprot_sec
E0CZH3
resolver
amino_acid_sequence
MALYCGDNFVYSQPAAAPGAPPTSRAPYGLSDYAAPPAAAANPYLWLNGPGVGGPASAASYLGAPPPPPGAAPGPFLQPPAAPGTFAGAQRGFAQPSASAPASPAGSAAPGELGWLSMASREDLMKMVRPPYSYSALIAMAIQSAPERKLTLSHIYQFVADNFPFYQRSKAGWQNSIRHNLSLNDCFKKVPRDEDDPGKGNYWTLDPNCEKMFDNGNFRRKRRRRAEASSNLTVPSGTSKSEGQSSRLRVSGKLEGDSPSSILRPSQSPEPPEGTKSTASSPGASTLTSTPCLNTFLSTFNTLNVNSSSSMGNQRTLPGSRRHLGGTQLPSSTFPNTSVPDSSPDSMQLSTVGGSNQLSSYYNPFSGGSSGDQSSPFSSPFYNFSMVNSLIYPRDGSDI
uniprot
proteins
function
FUNCTION: Transcription factor required for pharyngeal arch development, which is involved in hair, ear, jaw and dental development (PubMed:24650709, PubMed:26550799, PubMed:26992132, PubMed:30467319). May act as a pioneer transcription factor during pharyngeal arch development (PubMed:26550799, PubMed:26992132). Required for epithelial cell differentiation within the epidermis (PubMed:26450968). Acts at multiple stages of otic placode induction: necessary for preplacodal ectoderm to execute an inner ear program (PubMed:26550799). Required for hair follicle stem cell specification (PubMed:26992132). Acts downstream of TBX1 for the formation of the thymus and parathyroid glands from the third pharyngeal pouch (PubMed:31412026). {ECO:0000269|PubMed:24650709, ECO:0000269|PubMed:26450968, ECO:0000269|PubMed:26550799, ECO:0000269|PubMed:26992132, ECO:0000269|PubMed:30467319, ECO:0000269|PubMed:31412026}.
uniprot
proteins
mass_dalton
42015
uniprot
proteins
mutagenesis
MUTAGEN 99..103; /note="SAPAS->AAPAA: Reduced transcription factor activity."; /evidence="ECO:0000269|PubMed:30467319"; MUTAGEN 200..224; /note="GNYWTLDPNCEKMFDNGNFRRKRRR->WRQH: Knockin mice are significantly smaller and die immediately after birth. They show a partially truncated mandible and fusion of the upper and lower jaws (syngnathia) and anomalies of various bones of the ear."; /evidence="ECO:0000269|PubMed:37041148"; MUTAGEN 218; /note="F->L: Knockin mice hemizygous for L-218 mutant and a deletion of the wild-type Foxi3 allele fail to thrive after birth, are underweight, display respiratory abnormalities and die between birth and day 5."; /evidence="ECO:0000269|PubMed:37041148"; MUTAGEN 219..225; /note="RRKRRRR->AAAAAAA: Abolished localization to the nucleus."; /evidence="ECO:0000269|PubMed:30467319"; MUTAGEN 224; /note="R->L: Does not affect nuclear localization."; /evidence="ECO:0000269|PubMed:37041148"; MUTAGEN 258; /note="S->A: Does not affect transcription factor activity."; /evidence="ECO:0000269|PubMed:30467319"; MUTAGEN 266..268; /note="SQS->AQA: Does not affect transcription factor activity."; /evidence="ECO:0000269|PubMed:30467319"; MUTAGEN 385..393; /note="SMVNSLIYP->AAAAAAAAA: In Mut2; strongly reduced transcription factor activity."; /evidence="ECO:0000269|PubMed:30467319"; MUTAGEN 386..391; /note="MVNSLI->AANSAA: In Mut1; reduced transcription factor activity."; /evidence="ECO:0000269|PubMed:30467319
uniprot
proteins
post_translational_modification
PTM: Phosphorylation promotes the transcription factor activity (PubMed:30467319). Dephosphorylation by protein phosphatase 2A (PP2A) reduces its activity (PubMed:30467319). {ECO:0000269|PubMed:30467319}.
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23441037
uniprot
proteins
pubmed
24650709
uniprot
proteins
pubmed
26450968
uniprot
proteins
pubmed
26550799
uniprot
proteins
pubmed
26992132
uniprot
proteins
pubmed
30467319
uniprot
proteins
pubmed
31412026
uniprot
proteins
pubmed
37041148
uniprot
proteins
sequence_length
399
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:30467319, ECO:0000269|PubMed:37041148}.
uniprot
proteins