Rexo2
entrez
104444
canonical
uniprot
Q9D8S4
canonical
ensembl
ENSMUSG00000032026
resolver
ensp
ENSMUSP00000034524
resolver
ensp
ENSMUSP00000149074
resolver
ensp
ENSMUSP00000149784
resolver
enst
ENSMUST00000034524
resolver
enst
ENSMUST00000216470
resolver
enst
ENSMUST00000217037
resolver
genesymbol
Rexo2
resolver
genesymbol_syn
Smfn
resolver
uniprot
A0A1L1SQJ5
resolver
uniprot
A0A1L1SS70
resolver
uniprot_entry
A0A1L1SQJ5_MOUSE
resolver
uniprot_entry
A0A1L1SS70_MOUSE
resolver
uniprot_entry
ORN_MOUSE
resolver
amino_acid_sequence
MLGVSLGARLLRGVGGRRGQFGARGVSEGSAAMAAGESMAQRMVWVDLEMTGLDIEKDQIIEMACLITDSDLNILAEGPNLIIKQPDELLDSMSDWCKEHHGKSGLTKAVKESTVTLQQAEYEFLSFVRQQTPPGLCPLAGNSVHADKKFLDKHMPQFMKHLHYRIIDVSTVKELCRRWYPEDYEFAPKKAASHRALDDISESIKELQFYRNNIFKKKTDEKKRKIIENGETEKPVS
uniprot
proteins
ec_number
3.1.15.-
uniprot
proteins
function
FUNCTION: 3'-to-5'exoribonuclease that preferentially degrades DNA and RNA oligonucleotides composed of only two nucleotides (PubMed:31588022). Binds and degrades longer oligonucleotides with a lower affinity (By similarity). Plays dual roles in mitochondria, scavenging nanoRNAs (small RNA oligonucleotides of <5 nucleotides) that are produced by the degradosome and clearing short RNAs that are generated by RNA processing (By similarity). Essential for correct initiation of mitochondrial transcription, degrading mitochondrial RNA dinucleotides to prevent RNA-primed transcription at non-canonical sites in the mitochondrial genome (PubMed:31588022). Essential for embryonic development (PubMed:31588022). {ECO:0000250|UniProtKB:Q9Y3B8, ECO:0000269|PubMed:31588022}.
uniprot
proteins
mass_dalton
26739
uniprot
proteins
protein_family
Oligoribonuclease family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
31588022
uniprot
proteins
sequence_length
237
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000250|UniProtKB:Q9Y3B8}. Mitochondrion matrix {ECO:0000250|UniProtKB:Q9Y3B8}. Mitochondrion {ECO:0000250|UniProtKB:Q9Y3B8}. Cytoplasm {ECO:0000250|UniProtKB:Q9Y3B8}. Nucleus {ECO:0000250|UniProtKB:Q9Y3B8}.
uniprot
proteins