STAT6
entrez
6778
canonical
uniprot
P42226
canonical
ensembl
ENSG00000166888
resolver
ensp
ENSP00000300134
resolver
ensp
ENSP00000401486
resolver
ensp
ENSP00000438451
resolver
ensp
ENSP00000444530
resolver
ensp
ENSP00000445409
resolver
ensp
ENSP00000450732
resolver
ensp
ENSP00000452203
resolver
ensp
ENSP00000491116
resolver
genesymbol
STAT6
resolver
hgnc
HGNC:11368
resolver
uniprot
A8K316
resolver
uniprot
A8K4S9
resolver
uniprot
B4DQB3
resolver
uniprot
B7ZA27
resolver
uniprot
F5GXI9
resolver
uniprot
Q5FBW5
resolver
uniprot
Q71UP4
resolver
uniprot_entry
A8K4S9_HUMAN
resolver
uniprot_entry
B4DQB3_HUMAN
resolver
uniprot_entry
STAT6_HUMAN
resolver
uniprot_sec
A8K316
resolver
uniprot_sec
B7ZA27
resolver
uniprot_sec
F5GXI9
resolver
uniprot_sec
Q5FBW5
resolver
uniprot_sec
Q71UP4
resolver
amino_acid_sequence
MSLWGLVSKMPPEKVQRLYVDFPQHLRHLLGDWLESQPWEFLVGSDAFCCNLASALLSDTVQHLQASVGEQGEGSTILQHISTLESIYQRDPLKLVATFRQILQGEKKAVMEQFRHLPMPFHWKQEELKFKTGLRRLQHRVGEIHLLREALQKGAEAGQVSLHSLIETPANGTGPSEALAMLLQETTGELEAAKALVLKRIQIWKRQQQLAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGGELEPKTRASLTGRLDEVLRTLVTSCFLVEKQPPQVLKTQTKFQAGVRFLLGLRFLGAPAKPPLVRADMVTEKQARELSVPQGPGAGAESTGEIINNTVPLENSIPGNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSASFTLGPGKLPIQLQALSLPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEHFLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSPQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVPATIKMTVERDQPLPTPELQMPTMVPSYDLGMAPDSSMSMQLGPDMVPQVYPPHSHSIPPYQGLSPEESVNVLSAFQEPHLQMPPSLGQMSLPFDQPHPQGLLPCQPQEHAVSSPDPLLCSDVTMVEDSCLSQPVTAFPQGTWIGEDIFPPLLPPTEQDLTKLLLEGQGESGGGSLGAQPLLQPSHYGQSGISMSHMDLRANPSW
uniprot
proteins
disease_involvement
DISEASE: Hyper-IgE syndrome 6, autosomal dominant, with recurrent infections (HIES6) [MIM:620532]: An immunologic disorder characterized by severe allergic disease with onset in infancy. Common features are treatment-resistant atopic dermatitis, food allergies, asthma, eosinophilic gastrointestinal disease, and severe episodes of anaphylaxis. Half of the patients present with recurrent skin, respiratory, and viral infections. Clinical laboratory testing is notable for eosinophilia and markedly elevated serum IgE levels. {ECO:0000269|PubMed:36758835, ECO:0000269|PubMed:36884218, ECO:0000269|PubMed:37316763}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling. {ECO:0000269|PubMed:17210636, ECO:0000269|PubMed:36758835, ECO:0000269|PubMed:36884218}.
uniprot
proteins
mass_dalton
94135
uniprot
proteins
mutagenesis
MUTAGEN 641; /note="Y->F: Abolishes phosphorylation. Loss of DNA-binding transcription factor activity."; /evidence="ECO:0000269|PubMed:36884218"; MUTAGEN 802; /note="L->A: Abolishes the interaction with NCOA1; when associated with A-805."; /evidence="ECO:0000269|PubMed:12138096"; MUTAGEN 805; /note="L->A: Abolishes the interaction with NCOA1; when associated with A-802."; /evidence="ECO:0000269|PubMed:12138096
uniprot
proteins
post_translational_modification
PTM: Tyrosine phosphorylated on Tyr-641 following stimulation by IL4/interleukin-4 (PubMed:27796300). Tyrosine phosphorylated following stimulation by IL3/interleukin-3 (By similarity). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling (PubMed:17210636). {ECO:0000250|UniProtKB:P52633, ECO:0000269|PubMed:17210636, ECO:0000269|PubMed:27796300}.; PTM: Mono-ADP-ribosylated by PARP14. {ECO:0000269|PubMed:27796300}.
uniprot
proteins
protein_family
Transcription factor STAT family
uniprot
proteins
pubmed
12138096
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14757047
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17210636
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
27796300
uniprot
proteins
pubmed
36758835
uniprot
proteins
pubmed
36884218
uniprot
proteins
pubmed
37316763
uniprot
proteins
pubmed
8085155
uniprot
proteins
pubmed
9782085
uniprot
proteins
sequence_length
847
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000269|PubMed:36758835}. Note=Translocated into the nucleus in response to phosphorylation. {ECO:0000269|PubMed:36758835}.
uniprot
proteins