SGTA
entrez
6449
canonical
uniprot
O43765
canonical
ensembl
ENSG00000104969
resolver
ensp
ENSP00000221566
resolver
ensp
ENSP00000503397
resolver
ensp
ENSP00000504495
resolver
ensp
ENSP00000567141
resolver
ensp
ENSP00000567142
resolver
ensp
ENSP00000567144
resolver
ensp
ENSP00000567145
resolver
ensp
ENSP00000567146
resolver
ensp
ENSP00000597790
resolver
ensp
ENSP00000597791
resolver
ensp
ENSP00000597794
resolver
ensp
ENSP00000597795
resolver
ensp
ENSP00000597797
resolver
ensp
ENSP00000597798
resolver
ensp
ENSP00000597799
resolver
ensp
ENSP00000597800
resolver
ensp
ENSP00000622698
resolver
ensp
ENSP00000622699
resolver
ensp
ENSP00000622700
resolver
enst
ENST00000221566
resolver
enst
ENST00000676943
resolver
enst
ENST00000677149
resolver
enst
ENST00000897082
resolver
enst
ENST00000897083
resolver
enst
ENST00000897085
resolver
enst
ENST00000897086
resolver
enst
ENST00000897087
resolver
enst
ENST00000927731
resolver
enst
ENST00000927732
resolver
enst
ENST00000927735
resolver
enst
ENST00000927736
resolver
enst
ENST00000927738
resolver
enst
ENST00000927739
resolver
enst
ENST00000927740
resolver
enst
ENST00000927741
resolver
enst
ENST00000952639
resolver
enst
ENST00000952640
resolver
enst
ENST00000952641
resolver
genesymbol
SGTA
resolver
genesymbol_syn
SGT
resolver
genesymbol_syn
SGT1
resolver
hgnc
HGNC:10819
resolver
uniprot
D6W610
resolver
uniprot
Q6FIA9
resolver
uniprot
Q9BTZ9
resolver
uniprot_entry
SGTA_HUMAN
resolver
uniprot_sec
D6W610
resolver
uniprot_sec
Q6FIA9
resolver
uniprot_sec
Q9BTZ9
resolver
amino_acid_sequence
MDNKKRLAYAIIQFLHDQLRHGGLSSDAQESLEVAIQCLETAFGVTVEDSDLALPQTLPEIFEAAATGKEMPQDLRSPARTPPSEEDSAEAERLKTEGNEQMKVENFEAAVHFYGKAIELNPANAVYFCNRAAAYSKLGNYAGAVQDCERAICIDPAYSKAYGRMGLALSSLNKHVEAVAYYKKALELDPDNETYKSNLKIAELKLREAPSPTGGVGSFDIAGLLNNPGFMSMASNLMNNPQIQQLMSGMISGGNNPLGTPGTSPSQNDLASLIQAGQQFAQQMQQQNPELIEQLRSQIRSRTPSASNDDQQE
uniprot
proteins
function
FUNCTION: Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails (PubMed:28104892). Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module (PubMed:28104892). Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins (PubMed:25535373, PubMed:28104892). It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states (PubMed:23129660, PubMed:25179605). Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (PubMed:27193484). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:18759457). {ECO:0000269|PubMed:18759457, ECO:0000269|PubMed:23129660, ECO:0000269|PubMed:25179605, ECO:0000269|PubMed:25535373, ECO:0000269|PubMed:27193484, ECO:0000269|PubMed:28104892}.; FUNCTION: (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection via interaction with DNAJB12, DNAJB14 and HSPA8/Hsc70 (PubMed:24675744). {ECO:0000269|PubMed:24675744}.
uniprot
proteins
mass_dalton
34063
uniprot
proteins
mutagenesis
MUTAGEN 38; /note="C->A: Reduces tail-anchored proteins transfer."; /evidence="ECO:0000269|PubMed:25535373
uniprot
proteins
protein_family
SGT family
uniprot
proteins
pubmed
10567422
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15708368
uniprot
proteins
pubmed
16580629
uniprot
proteins
pubmed
16580632
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17034881
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18759457
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23129660
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24675744
uniprot
proteins
pubmed
25179605
uniprot
proteins
pubmed
25535373
uniprot
proteins
pubmed
27193484
uniprot
proteins
pubmed
28104892
uniprot
proteins
pubmed
9573291
uniprot
proteins
pubmed
9740675
uniprot
proteins
sequence_length
313
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16580629}. Nucleus {ECO:0000269|PubMed:16580629}. Note=Co-localizes with HSP90AB1 in the cytoplasm. Increased nuclear accumulation seen during cell apoptosis. {ECO:0000269|PubMed:16580629}.
uniprot
proteins