TATDN1
entrez
83940
canonical
uniprot
Q6P1N9
canonical
ensembl
ENSG00000147687
resolver
ensembl
ENSG00000291730
resolver
ensp
ENSP00000276692
resolver
ensp
ENSP00000428336
resolver
ensp
ENSP00000430274
resolver
ensp
ENSP00000476180
resolver
ensp
ENSP00000487380
resolver
ensp
ENSP00000517242
resolver
ensp
ENSP00000536173
resolver
ensp
ENSP00000603777
resolver
ensp
ENSP00000657808
resolver
enst
ENST00000630259
resolver
enst
ENST00000708479
resolver
genesymbol
TATDN1
resolver
hgnc
HGNC:24220
resolver
uniprot
A0A0D9SGD3
resolver
uniprot
B2R5J0
resolver
uniprot
Q8TD02
resolver
uniprot
Q9BY40
resolver
uniprot_entry
A0A0D9SGD3_HUMAN
resolver
uniprot_entry
TATD1_HUMAN
resolver
uniprot_sec
B2R5J0
resolver
uniprot_sec
Q8TD02
resolver
uniprot_sec
Q9BY40
resolver
activity_regulation
ACTIVITY REGULATION: 3'-exonuclease activity is suppressed in presence of Ca(2+), Zn(2+) and Ni(2+). {ECO:0000269|PubMed:36881763}.
uniprot
proteins
amino_acid_sequence
MSRFKFIDIGINLTDPMFRGIYRGVQKHQDDLQDVIGRAVEIGVKKFMITGGNLQDSKDALHLAQTNGMFFSTVGCHPTRCGEFEKNNPDLYLKELLNLAENNKGKVVAIGECGLDFDRLQFCPKDTQLKYFEKQFELSEQTKLPMFLHCRNSHAEFLDIMKRNRDRCVGGVVHSFDGTKEAAAALIDLDLYIGFNGCSLKTEANLEVLKSIPSEKLMIETDAPWCGVKSTHAGSKYIRTAFPTKKKWESGHCLKDRNEPCHIIQILEIMSAVRDEDPLELANTLYNNTIKVFFPGI
uniprot
proteins
ec_number
3.1.11.-
uniprot
proteins
ec_number
3.1.21.-
uniprot
proteins
function
FUNCTION: Exhibits 3'-5' exonuclease and apurinic/apyrimidinic (AP) endonuclease activities (in vitro) (PubMed:36881763). Shows preferential AP endonuclease activity on dsDNA substrates and 3'-5' exonuclease activity on ssDNA (PubMed:36881763). Catalyzes decatenation of catenated kinetoplast DNA to produce separated linear DNA in vitro (By similarity). Plays an important role in chromosomal segregation and cell cycle progression during eye development probably via its DNA decatenation activity (By similarity). {ECO:0000250|UniProtKB:Q6GML7, ECO:0000269|PubMed:36881763}.
uniprot
proteins
mass_dalton
33602
uniprot
proteins
mutagenesis
MUTAGEN 77; /note="H->A: Reduces AP endodeoxyribonuclease activity 10-fold. Does not affect the exonuclease activity."; /evidence="ECO:0000269|PubMed:36881763"; MUTAGEN 112; /note="E->A: Reduces AP endodeoxyribonuclease and 3'-exonuclease activities."; /evidence="ECO:0000269|PubMed:36881763"; MUTAGEN 112; /note="E->Q: Increases AP endodeoxyribonuclease and 3'-exonuclease activities."; /evidence="ECO:0000269|PubMed:36881763"; MUTAGEN 119; /note="R->A: Severely reduced the AP endodeoxyribonuclease activity in double-stranded DNA. Reduced the 3'-exonuclease activity on ssDNA."; /evidence="ECO:0000269|PubMed:36881763"; MUTAGEN 119; /note="R->E: Does not affect the AP endodeoxyribonuclease activity in double-stranded DNA. Reduced the 3'-exonuclease activity on ssDNA."; /evidence="ECO:0000269|PubMed:36881763"; MUTAGEN 222; /note="D->A: Does not affect either AP endodeoxyribonuclease or 3'-exonuclease activities."; /evidence="ECO:0000269|PubMed:36881763
uniprot
proteins
protein_family
Metallo-dependent hydrolases superfamily
uniprot
proteins
protein_family
TatD-type hydrolase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
36881763
uniprot
proteins
sequence_length
297
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins