Bdh2
entrez
69772
canonical
uniprot
Q8JZV9
canonical
ensembl
ENSMUSG00000028167
resolver
ensp
ENSMUSP00000029817
resolver
ensp
ENSMUSP00000112683
resolver
enst
ENSMUST00000029817
resolver
enst
ENSMUST00000120397
resolver
genesymbol
Bdh2
resolver
genesymbol_syn
Dhrs6
resolver
uniprot
G3UWD3
resolver
uniprot_entry
DHRS6_MOUSE
resolver
uniprot_entry
G3UWD3_MOUSE
resolver
amino_acid_sequence
MGRLDGKVIVLTAAAQGIGRASALAFAREGAKVIATDINESKLQELESYRGIQTRVLDVTKKRQIDQFASEIERIDVLFNVAGFVHHGTILDCEEKDWDFSMNLNVRSMFLMIKAFLPKMLAQKSGNIINMSSVASSIKGVENRCVYSATKAAVIGLTKSVAADFIQQGIRCNCVCPGTVDTPSLQERIQARDNPKEALKTFLNRQKTGRFASAEEVALLCVYLASDESAYVTGNPVIIDGGWSL
uniprot
proteins
ec_number
1.1.1.-
uniprot
proteins
ec_number
1.1.1.104
uniprot
proteins
ec_number
1.1.1.30
uniprot
proteins
function
FUNCTION: NAD(H)-dependent dehydrogenase/reductase with a preference for cyclic substrates (By similarity). Catalyzes stereoselective conversion of 4-oxo-L-proline to cis-4-hydroxy-L-proline, likely a detoxification mechanism for ketoprolines (By similarity). Mediates the formation of 2,5-dihydroxybenzoate (2,5-DHBA), a siderophore that chelates free cytoplasmic iron and associates with LCN2, thereby regulating iron transport and homeostasis while protecting cells against free radical-induced oxidative stress. The iron-siderophore complex is imported into mitochondria, providing an iron source for mitochondrial metabolic processes in particular heme synthesis (PubMed:20550936, PubMed:24777603, PubMed:24863067). May act as a 3-hydroxybutyrate dehydrogenase (By similarity). {ECO:0000250|UniProtKB:D4A1J4, ECO:0000250|UniProtKB:Q9BUT1, ECO:0000269|PubMed:20550936, ECO:0000269|PubMed:24777603, ECO:0000269|PubMed:24863067}.; FUNCTION: (Microbial infection) May play a role in susceptibility to bacterial infection by providing an assimilable source of iron that is exploited by pathogenic bacteria. Host iron-siderophore complexes can be used by bacteria to promote their own growth and pathogenicity. {ECO:0000269|PubMed:24863067}.
uniprot
proteins
mass_dalton
26753
uniprot
proteins
mutagenesis
MUTAGEN 147; /note="Y->F: Loss of function."; /evidence="ECO:0000269|PubMed:20550936
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid metabolism. {ECO:0000250|UniProtKB:Q9BUT1}.; PATHWAY: Siderophore biosynthesis. {ECO:0000269|PubMed:20550936, ECO:0000269|PubMed:24863067}.
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20550936
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24777603
uniprot
proteins
pubmed
24863067
uniprot
proteins
sequence_length
245
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BUT1}.
uniprot
proteins