KLF15
entrez
28999
canonical
uniprot
Q9UIH9
canonical
ensembl
ENSG00000163884
resolver
ensp
ENSP00000296233
resolver
ensp
ENSP00000562132
resolver
ensp
ENSP00000562133
resolver
ensp
ENSP00000562134
resolver
ensp
ENSP00000562135
resolver
ensp
ENSP00000562136
resolver
enst
ENST00000296233
resolver
enst
ENST00000892073
resolver
enst
ENST00000892074
resolver
enst
ENST00000892075
resolver
enst
ENST00000892076
resolver
enst
ENST00000892077
resolver
genesymbol
KLF15
resolver
genesymbol_syn
KKLF
resolver
hgnc
HGNC:14536
resolver
uniprot_entry
KLF15_HUMAN
resolver
amino_acid_sequence
MVDHLLPVDENFSSPKCPVGYLGDRLVGRRAYHMLPSPVSEDDSDASSPCSCSSPDSQALCSCYGGGLGTESQDSILDFLLSQATLGSGGGSGSSIGASSGPVAWGPWRRAAAPVKGEHFCLPEFPLGDPDDVPRPFQPTLEEIEEFLEENMEPGVKEVPEGNSKDLDACSQLSAGPHKSHLHPGSSGRERCSPPPGGASAGGAQGPGGGPTPDGPIPVLLQIQPVPVKQESGTGPASPGQAPENVKVAQLLVNIQGQTFALVPQVVPSSNLNLPSKFVRIAPVPIAAKPVGSGPLGPGPAGLLMGQKFPKNPAAELIKMHKCTFPGCSKMYTKSSHLKAHLRRHTGEKPFACTWPGCGWRFSRSDELSRHRRSHSGVKPYQCPVCEKKFARSDHLSKHIKVHRFPRSSRSVRSVN
uniprot
proteins
disease_involvement
DISEASE: Note=KLF15 deficiency results in loss of rhythmic QT variation and abnormal heart repolarization (PubMed:22367544). It may play a role in susceptibility to ventricular arrhythmias (PubMed:22367544), and development of pathological cardiac hypertrophy leading to heart failure (PubMed:20375365). {ECO:0000269|PubMed:20375365, ECO:0000269|PubMed:22367544}.
uniprot
proteins
function
FUNCTION: Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation. {ECO:0000250, ECO:0000269|PubMed:18586263, ECO:0000269|PubMed:20375365, ECO:0000269|PubMed:20566642, ECO:0000269|PubMed:23999430}.
uniprot
proteins
mass_dalton
43992
uniprot
proteins
protein_family
Sp1 C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
10982849
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17438289
uniprot
proteins
pubmed
18586263
uniprot
proteins
pubmed
20375365
uniprot
proteins
pubmed
20566642
uniprot
proteins
pubmed
22367544
uniprot
proteins
pubmed
22493483
uniprot
proteins
pubmed
23999430
uniprot
proteins
pubmed
31375868
uniprot
proteins
sequence_length
416
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10982849, ECO:0000269|PubMed:17438289}.
uniprot
proteins