Amd1
entrez
11702
canonical
uniprot
P0DMN7
canonical
ensembl
ENSMUSG00000075232
resolver
ensp
ENSMUSP00000097528
resolver
ensp
ENSMUSP00000159133
resolver
enst
ENSMUST00000099945
resolver
enst
ENSMUST00000238969
resolver
genesymbol
Amd1
resolver
uniprot
P31154
resolver
uniprot
P82184
resolver
uniprot
Q58E47
resolver
uniprot_entry
DCAM1_MOUSE
resolver
uniprot_sec
P31154
resolver
uniprot_sec
P82184
resolver
uniprot_sec
Q58E47
resolver
amino_acid_sequence
MEAAHFFEGTEKLLEVWFSRQQSDASQGSGDLRTIPRSEWDVLLKDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATLFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLSSPQKIDGFKRLDCQSAMFNDYNFVFTSFAKKQQQQQS
uniprot
proteins
ec_number
4.1.1.50
uniprot
proteins
function
FUNCTION: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. {ECO:0000269|PubMed:22391449}.
uniprot
proteins
mass_dalton
38272
uniprot
proteins
pathway_participation
PATHWAY: Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1.
uniprot
proteins
post_translational_modification
PTM: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain. {ECO:0000250|UniProtKB:P17707}.
uniprot
proteins
protein_family
Eukaryotic AdoMetDC family
uniprot
proteins
pubmed
10570962
uniprot
proteins
pubmed
11856372
uniprot
proteins
pubmed
1449493
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
22391449
uniprot
proteins
pubmed
8344293
uniprot
proteins
sequence_length
334
uniprot
proteins