Bloc1s1
entrez
288785
canonical
uniprot
D3ZKU7
canonical
ensembl
ENSRNOG00000007784
resolver
ensembl
ENSRNOG00055014529
resolver
ensembl
ENSRNOG00060027607
resolver
ensembl
ENSRNOG00065012966
resolver
ensp
ENSRNOP00000010380
resolver
ensp
ENSRNOP00055020363
resolver
ensp
ENSRNOP00060039877
resolver
ensp
ENSRNOP00065016378
resolver
enst
ENSRNOT00000010380
resolver
enst
ENSRNOT00055024923
resolver
enst
ENSRNOT00060047932
resolver
enst
ENSRNOT00065021218
resolver
genesymbol
Bloc1s1
resolver
uniprot_entry
BL1S1_RAT
resolver
amino_acid_sequence
MLSRLLKEHQAKQNERKELQEKRRREAITAATCLTEALVDHLNVGVAQAYMNQRKLDHEVKTLQVQAAQFAKQTGQWIGMVENFNQALKEIGDVENWARSIELDMRTIATALEYVYKGQLQSAPS
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
function
FUNCTION: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. The BORC complex is most probably associated with the cytosolic face of lysosomes, may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor. {ECO:0000250|UniProtKB:P78537}.; FUNCTION: Acts as a protein acetyltransferase. Negatively regulates aerobic respiration through mitochondrial protein lysine-acetylation. May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9. Acts as a regulator of mTORC2 signaling in response to hypotoxic stress by mediating acetylation of RICTOR, thereby protecting RICTOR against ubiquitination and subsequent degradation by the proteasome. {ECO:0000250|UniProtKB:P78537}.
uniprot
proteins
mass_dalton
14311
uniprot
proteins
protein_family
BLOC1S1 family
uniprot
proteins
sequence_length
125
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000250|UniProtKB:P78537}. Mitochondrion matrix {ECO:0000250|UniProtKB:P78537}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P78537}. Lysosome membrane {ECO:0000250|UniProtKB:P78537}.
uniprot
proteins