Ptpn12
entrez
19248
canonical
uniprot
P35831
canonical
ensembl
ENSMUSG00000028771
resolver
ensp
ENSMUSP00000030556
resolver
ensp
ENSMUSP00000237622
resolver
enst
ENSMUST00000030556
resolver
genesymbol
Ptpn12
resolver
uniprot
Q80UM4
resolver
uniprot_entry
PTN12_MOUSE
resolver
uniprot_sec
Q80UM4
resolver
amino_acid_sequence
MEQVEILRRFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCENEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKIADGNEITTGTMVSSIDSEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDSDRYHPKPVLHMASPEQHPADLNRSYDKSADPMGKSESAIEHIDKKLERNLSFEIKKVPLQEGPKSFDGNTLLNRGHAIKIKSASSSVVDRTSKPQELSAGALKVDDVSQNSCADCSAAHSHRAAESSEESQSNSHTPPRPDCLPLDKKGHVTWSLHGPENATPVPDSPDGKSPDNHSQTLKTVSSTPNSTAEEEAHDLTEHHNSSPLLKAPLSFTNPLHSDDSDSDGGSSDGAVTRNKTSISTASATVSPASSAESACTRRVLPMSIARQEVAGTPHSGAEKDADVSEESPPPLPERTPESFVLADMPVRPEWHELPNQEWSEQRESEGLTTSGNEKHDAGGIHTEASADSPPAFSDKKDQITKSPAEVTDIGFGNRCGKPKGPREPPSEWT
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:17070019). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2. Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (By similarity). {ECO:0000250|UniProtKB:Q05209, ECO:0000269|PubMed:17070019}.
uniprot
proteins
mass_dalton
86526
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by STK24/MST3 and this results in inhibition of its activity. {ECO:0000250|UniProtKB:Q05209}.
uniprot
proteins
protein_family
Non-receptor class 4 subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
10092676
uniprot
proteins
pubmed
11711533
uniprot
proteins
pubmed
12674328
uniprot
proteins
pubmed
1472029
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15786712
uniprot
proteins
pubmed
1590786
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17070019
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7772023
uniprot
proteins
sequence_length
775
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12674328, ECO:0000269|PubMed:7772023}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q05209}. Cell projection, podosome {ECO:0000269|PubMed:12674328}. Note=Partial translocation to focal adhesion sites might be mediated by interaction with SORBS2. {ECO:0000250|UniProtKB:Q05209}.
uniprot
proteins