Ddah2
entrez
294239
canonical
uniprot
Q6MG60
canonical
ensembl
ENSRNOG00000000842
resolver
ensembl
ENSRNOG00055007228
resolver
ensembl
ENSRNOG00060004372
resolver
ensembl
ENSRNOG00065032128
resolver
ensp
ENSRNOP00000069121
resolver
ensp
ENSRNOP00055009521
resolver
ensp
ENSRNOP00060005574
resolver
ensp
ENSRNOP00065045516
resolver
enst
ENSRNOT00000088251
resolver
enst
ENSRNOT00055012017
resolver
enst
ENSRNOT00060007344
resolver
enst
ENSRNOT00065055326
resolver
genesymbol
Ddah2
resolver
uniprot_entry
DDAH2_RAT
resolver
amino_acid_sequence
MGTPGEGLGRCSHALIRGVPESLASGEGAGAGLPALDLAKAQREHGVLGGKLRQRLGLQLLELPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDGVRKALQDLGLRIVEMGDENATLDGTDVLFTGREFFVGLSKWTNHRGAEIVADTFRDFAVSTVPVSGASHLRGLCGMGGPRTVVAGSSEAAQKAVRAMAALTDHPYASLTLPDDAASDCLFLRPGLPGTTPFLLHRGGGDLPNSQEALQKLSDVTLVPVSCSELEKVGAGLSSLCLVLSTRPHC
uniprot
proteins
ec_number
3.-.-.-
uniprot
proteins
function
FUNCTION: Putative hydrolase with unknown substrate. Does not hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA) which acts as an inhibitor of NOS (By similarity). In endothelial cells, induces expression of vascular endothelial growth factor (VEGF) via phosphorylation of the transcription factor SP1 by PKA in a process that is independent of NO and NO synthase. Similarly, enhances pancreatic insulin secretion through SP1-mediated transcriptional up-regulation of secretagogin/SCGN, an insulin vesicle docking protein (By similarity). Upon viral infection, relocates to mitochondria where it promotes mitochondrial fission through activation of DNM1L leading to the inhibition of innate response activation mediated by MAVS (By similarity). {ECO:0000250|UniProtKB:O95865, ECO:0000250|UniProtKB:Q99LD8}.
uniprot
proteins
mass_dalton
29688
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by TBK1. Phosphorylation inhibits the translocation into the mitochondrion upon Sendai viral infection. {ECO:0000250|UniProtKB:O95865}.
uniprot
proteins
protein_family
DDAH family
uniprot
proteins
pubmed
15060004
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
285
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O95865}. Mitochondrion {ECO:0000250|UniProtKB:O95865}. Note=Translocates from cytosol to mitochondrion upon IL1B stimulation in chondrocytes. {ECO:0000250|UniProtKB:O95865}.
uniprot
proteins