Dph5
entrez
69740
canonical
uniprot
Q9CWQ0
canonical
ensembl
ENSMUSG00000033554
resolver
ensp
ENSMUSP00000043730
resolver
ensp
ENSMUSP00000140958
resolver
ensp
ENSMUSP00000183099
resolver
enst
ENSMUST00000043342
resolver
enst
ENSMUST00000189799
resolver
genesymbol
Dph5
resolver
uniprot
Q6PAC5
resolver
uniprot_entry
DPH5_MOUSE
resolver
uniprot_sec
Q6PAC5
resolver
amino_acid_sequence
MLYLIGLGLGDAKDITVKGLEVVRRCSRVYLEAYTSVLTVGKEALEEFYGRKLILADREEVEQEADNIFKDADVSDVAFLVVGDPFGATTHSDLILRATKLGIPYQVIHNASIMNAVGCCGLQLYRFGETVSIVFWTDTWRPESFFDKVKRNRANGMHTLCLLDIKVKEQSLENLIRGRKIYEPPRYMSVNQAAQQLLEIVQNHRARGEEPAITEETLCVGLARVGAEDQKIAAGTLQQMCTVSLGEPLHSLVITGGNLHPLEMEMLSLFSIPESQSTDGL
uniprot
proteins
ec_number
2.1.1.314
uniprot
proteins
function
FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. {ECO:0000250|UniProtKB:P32469, ECO:0000269|PubMed:15485916}.
uniprot
proteins
mass_dalton
31218
uniprot
proteins
mutagenesis
MUTAGEN 260; /note="H->R: Most homozygous embryos are non-viable and show craniofacial, ophthalmologic, cardiac, visceral, and hemopoietic abnormalities."; /evidence="ECO:0000269|PubMed:35482014
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; peptidyl-diphthamide biosynthesis.
uniprot
proteins
protein_family
Diphthine synthase family
uniprot
proteins
pubmed
15485916
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
35482014
uniprot
proteins
pubmed
36205747
uniprot
proteins
sequence_length
281
uniprot
proteins