P07882
uniprot
P07882
canonical
activity_regulation
ACTIVITY REGULATION: Activated by bile salts such as sodium taurocholate. {ECO:0000250|UniProtKB:P19835}.
uniprot
proteins
amino_acid_sequence
MGRLEVLFLGLTCCLAAACAAKLGAVYTEGGFVEGVNKKLSLLGGDSVDIFKGIPFATAKTLENPQRHPGWQGTLKATDFKKRCLQATITQDDTYGQEDCLYLNIWVPQGRKQVSHDLPVMVWIYGGAFLMGSGQGANFLKNYLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNFGLRDQHMAIAWVKRNIAAFGGDPDNITIFGESAGAASVSLQTLSPYNKGLIRRAISQSGVALSPWAIQENPLFWAKTIAKKVGCPTEDTAKMAGCLKITDPRALTLAYRLPLKSQEYPIVHYLAFIPVVDGDFIPDDPINLYDNAADIDYLAGINDMDGHLFATVDVPAIDKAKQDVTEEDFYRLVSGHTVAKGLKGTQATFDIYTESWAQDPSQENMKKTVVAFETDILFLIPTEMALAQHRAHAKSAKTYSYLFSHPSRMPIYPKWMGADHADDLQYVFGKPFATPLGYRAQDRTVSKAMIAYWTNFAKSGDPNMGNSPVPTHWYPYTTENGNYLDINKKITSTSMKEHLREKFLKFWAVTFEMLPTVVGDHTPPEDDSEAAPVPPTDDSQGGPVPPTDDSQTTPVPPTDNSQAGDSVEAQMPGPIGF
uniprot
proteins
ec_number
3.1.1.13
uniprot
proteins
ec_number
3.1.1.3
uniprot
proteins
ec_number
3.1.1.6
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of a wide range of substrates including cholesteryl esters, phospholipids, lysophospholipids, di- and tri-acylglycerols, and fatty acid esters of hydroxy fatty acids (FAHFA) (PubMed:1999399, PubMed:2211595). Preferentially hydrolyzes FAHFAs with the ester bond further away from the carboxylate. Unsaturated FAHFAs are hydrolyzed more quickly than saturated FAHFAs (By similarity). Has an essential role in the complete digestion of dietary lipids and their intestinal absorption, along with the absorption of fat-soluble vitamins (By similarity). {ECO:0000250|UniProtKB:P19835, ECO:0000250|UniProtKB:Q64285, ECO:0000269|PubMed:1999399, ECO:0000269|PubMed:2211595}.
uniprot
proteins
mass_dalton
67040
uniprot
proteins
mutagenesis
MUTAGEN 214; /note="S->T,A: Abolishes activity."; /evidence="ECO:0000269|PubMed:2211595"; MUTAGEN 440; /note="H->Q: No effect on activity."; /evidence="ECO:0000269|PubMed:1999399"; MUTAGEN 455; /note="H->Q,R,A,S,D: Abolishes activity."; /evidence="ECO:0000269|PubMed:1999399
uniprot
proteins
protein_family
Type-B carboxylesterase/lipase family
uniprot
proteins
pubmed
1999399
uniprot
proteins
pubmed
2069957
uniprot
proteins
pubmed
2211595
uniprot
proteins
pubmed
2688744
uniprot
proteins
pubmed
3593682
uniprot
proteins
sequence_length
612
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P19835}.
uniprot
proteins