RAD21L1
entrez
642636
canonical
uniprot
Q9H4I0
canonical
ensembl
ENSG00000244588
resolver
ensp
ENSP00000386414
resolver
ensp
ENSP00000507397
resolver
enst
ENST00000683101
resolver
genesymbol
RAD21L1
resolver
genesymbol_syn
RAD21L
resolver
hgnc
HGNC:16271
resolver
uniprot
A0A804HJ87
resolver
uniprot
B2RXL0
resolver
uniprot
B7ZBB1
resolver
uniprot
B7ZW76
resolver
uniprot
Q5W0X5
resolver
uniprot_entry
A0A804HJ87_HUMAN
resolver
uniprot_entry
RD21L_HUMAN
resolver
uniprot_sec
B2RXL0
resolver
uniprot_sec
B7ZBB1
resolver
uniprot_sec
B7ZW76
resolver
uniprot_sec
Q5W0X5
resolver
amino_acid_sequence
MFYTHVLMSKRGPLAKIWLAAHWEKKLTKAHVFECNLEITIEKILSPKVKIALRTSGHLLLGVVRIYNRKAKYLLADCSEAFLKMKMTFCPGLVDLPKENFEASYNAITLPEEFHDFDTQNMNAIDVSEHFTQNQSRPEEITLRENFDNDLIFQAESFGEESEILRRHSFFDDNILLNSSGPLIEHSSGSLTGERSLFYDSGDGFGDEGAAGEMIDNLLQDDQNILLEDMHLNREISLPSEPPNSLAVEPDNSECICVPENEKMNETILLSTEEEGFTLDPIDISDIAEKRKGKKRRLLIDPIKELSSKVIHKQLTSFADTLMVLELAPPTQRLMMWKKRGGVHTLLSTAAQDLIHAELKMLFTKCFLSSGFKLGRKMIQKESVREEVGNQNIVETSMMQEPNYQQELSKPQTWKDVIGGSQHSSHEDTNKNINSEQDIVEMVSLAAEESSLMNDLFAQEIEYSPVELESLSNEENIETERWNGRILQMLNRLRESNKMGMQSFSLMKLCRNSDRKQAAAKFYSFLVLKKQLAIELSQSAPYADIIATMGPMFYNI
uniprot
proteins
function
FUNCTION: Meiosis-specific component of some cohesin complex required during the initial steps of prophase I in male meiosis. Probably required during early meiosis in males for separation of sister chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S phase (during early stages of prophase I), while RAD21 reappears in later stages of prophase I. Involved in synaptonemal complex assembly, synapsis initiation and crossover recombination between homologous chromosomes during prophase I (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
63324
uniprot
proteins
protein_family
Rad21 family
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
32741963
uniprot
proteins
sequence_length
556
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:A2AU37}. Chromosome {ECO:0000250|UniProtKB:A2AU37}. Note=In meiotic chromosomes, localized along axial elements in early meiosis: detectable on the axial elements in leptotene, and stays on the axial/lateral elements until mid pachytene. It then disappears and is replaced with RAD21. Compared to REC8, has mutually exclusive loading sites on the chromosomes: REC8 and RAD21L form distinct cohesin-enriched domains along the axial elements. {ECO:0000250|UniProtKB:A2AU37}.
uniprot
proteins