PTPN5
entrez
84867
canonical
uniprot
P54829
canonical
ensembl
ENSG00000110786
resolver
ensp
ENSP00000351342
resolver
ensp
ENSP00000379471
resolver
ensp
ENSP00000379473
resolver
ensp
ENSP00000526283
resolver
ensp
ENSP00000627070
resolver
ensp
ENSP00000699055
resolver
genesymbol
PTPN5
resolver
hgnc
HGNC:9657
resolver
uniprot
B3KXG7
resolver
uniprot
B7Z2F8
resolver
uniprot
B7Z386
resolver
uniprot
B7ZAF5
resolver
uniprot
D3DQY7
resolver
uniprot
Q6P1Z2
resolver
uniprot
Q86TL3
resolver
uniprot
Q8N2A1
resolver
uniprot
Q8NDP8
resolver
uniprot_entry
B7Z2F8_HUMAN
resolver
uniprot_entry
PTN5_HUMAN
resolver
uniprot_entry
Q86TL3_HUMAN
resolver
uniprot_sec
B3KXG7
resolver
uniprot_sec
B7Z386
resolver
uniprot_sec
B7ZAF5
resolver
uniprot_sec
D3DQY7
resolver
uniprot_sec
Q6P1Z2
resolver
uniprot_sec
Q8N2A1
resolver
uniprot_sec
Q8NDP8
resolver
amino_acid_sequence
MNYEGARSERENHAADDSEGGALDMCCSERLPGLPQPIVMEALDEAEGLQDSQREMPPPPPPSPPSDPAQKPPPRGAGSHSLTVRSSLCLFAASQFLLACGVLWFSGYGHIWSQNATNLVSSLLTLLKQLEPTAWLDSGTWGVPSLLLVFLSVGLVLVTTLVWHLLRTPPEPPTPLPPEDRRQSVSRQPSFTYSEWMEEKIEDDFLDLDPVPETPVFDCVMDIKPEADPTSLTVKSMGLQERRGSNVSLTLDMCTPGCNEEGFGYLMSPREESAREYLLSASRVLQAEELHEKALDPFLLQAEFFEIPMNFVDPKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYIRGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTEYWPEEQVAYDGVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEKQLSHQSPE
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: May regulate the activity of several effector molecules involved in synaptic plasticity and neuronal cell survival, including MAPKs, Src family kinases and NMDA receptors. {ECO:0000269|PubMed:21777200}.
uniprot
proteins
mass_dalton
63538
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-245 by PKA deactivates PTPN5. Phosphorylation at Thr-255 and Ser-268 by MAPKs stabilizes the phosphatase, dephosphorylation of these sites results in ubiquitin-mediated degradation of the active phosphatase. {ECO:0000269|PubMed:21777200}.
uniprot
proteins
protein_family
Non-receptor class subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16441242
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21777200
uniprot
proteins
pubmed
7490079
uniprot
proteins
sequence_length
565
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 88..108; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 146..166; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins