ATG13
entrez
9776
canonical
uniprot
O75143
canonical
ensembl
ENSG00000175224
resolver
ensp
ENSP00000352500
resolver
ensp
ENSP00000431974
resolver
ensp
ENSP00000432412
resolver
ensp
ENSP00000433543
resolver
ensp
ENSP00000433756
resolver
ensp
ENSP00000434390
resolver
ensp
ENSP00000507809
resolver
ensp
ENSP00000560983
resolver
ensp
ENSP00000560984
resolver
ensp
ENSP00000560985
resolver
ensp
ENSP00000560986
resolver
ensp
ENSP00000560987
resolver
ensp
ENSP00000560988
resolver
ensp
ENSP00000560989
resolver
ensp
ENSP00000560991
resolver
ensp
ENSP00000560993
resolver
ensp
ENSP00000560994
resolver
ensp
ENSP00000560997
resolver
ensp
ENSP00000561000
resolver
ensp
ENSP00000561001
resolver
ensp
ENSP00000561003
resolver
ensp
ENSP00000561008
resolver
ensp
ENSP00000561009
resolver
ensp
ENSP00000561010
resolver
ensp
ENSP00000561017
resolver
ensp
ENSP00000561019
resolver
ensp
ENSP00000561020
resolver
ensp
ENSP00000604062
resolver
ensp
ENSP00000604067
resolver
ensp
ENSP00000604070
resolver
ensp
ENSP00000604073
resolver
ensp
ENSP00000630009
resolver
ensp
ENSP00000630012
resolver
ensp
ENSP00000630013
resolver
ensp
ENSP00000630014
resolver
ensp
ENSP00000630015
resolver
genesymbol
ATG13
resolver
genesymbol_syn
KIAA0652
resolver
hgnc
HGNC:29091
resolver
uniprot
A8K0S6
resolver
uniprot
B4DFI4
resolver
uniprot
D3DQQ1
resolver
uniprot
D3DQQ2
resolver
uniprot
E9PQZ8
resolver
uniprot
Q53EN6
resolver
uniprot
Q9BRL3
resolver
uniprot
Q9H8B0
resolver
uniprot_entry
A8K0S6_HUMAN
resolver
uniprot_entry
ATG13_HUMAN
resolver
uniprot_sec
B4DFI4
resolver
uniprot_sec
D3DQQ1
resolver
uniprot_sec
D3DQQ2
resolver
uniprot_sec
E9PQZ8
resolver
uniprot_sec
Q53EN6
resolver
uniprot_sec
Q9BRL3
resolver
uniprot_sec
Q9H8B0
resolver
amino_acid_sequence
METDLNSQDRKDLDKFIKFFALKTVQVIVQARLGEKICTRSSSSPTGSDWFNLAIKDIPEVTHEAKKALAGQLPAVGRSMCVEISLKTSEGDSMELEIWCLEMNEKCDKEIKVSYTVYNRLSLLLKSLLAITRVTPAYRLSRKQGHEYVILYRIYFGEVQLSGLGEGFQTVRVGTVGTPVGTITLSCAYRINLAFMSTRQFERTPPIMGIIIDHFVDRPYPSSSPMHPCNYRTAGEDTGVIYPSVEDSQEVCTTSFSTSPPSQLSSSRLSYQPAALGVGSADLAYPVVFAAGLNATHPHQLMVPGKEGGVPLAPNQPVHGTQADQERLATCTPSDRTHCAATPSSSEDTETVSNSSEGRASPHDVLETIFVRKVGAFVNKPINQVTLTSLDIPFAMFAPKNLELEDTDPMVNPPDSPETESPLQGSLHSDGSSGGSSGNTHDDFVMIDFKPAFSKDDILPMDLGTFYREFQNPPQLSSLSIDIGAQSMAEDLDSLPEKLAVHEKNVREFDAFVETLQ
uniprot
proteins
function
FUNCTION: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:19211835, ECO:0000269|PubMed:19225151, ECO:0000269|PubMed:19287211, ECO:0000269|PubMed:21795849, ECO:0000269|PubMed:21855797}.
uniprot
proteins
mass_dalton
56572
uniprot
proteins
mutagenesis
MUTAGEN 127; /note="S->H: Abolishes interaction with ATG101; when associated with D-133."; /evidence="ECO:0000269|PubMed:26299944"; MUTAGEN 131; /note="I->D: Decreases interaction with ATG101; when associated with D-134."; /evidence="ECO:0000269|PubMed:26299944"; MUTAGEN 133; /note="R->D: Abolishes interaction with ATG101; when associated with H-127."; /evidence="ECO:0000269|PubMed:26299944"; MUTAGEN 134; /note="V->D: Decreases interaction with ATG101; when associated with D-131."; /evidence="ECO:0000269|PubMed:26299944"; MUTAGEN 444; /note="F->A: Decreases interaction with MAP1LC3A."; /evidence="ECO:0000269|PubMed:24290141"; MUTAGEN 447; /note="I->A: Decreases interaction with MAP1LC3A."; /evidence="ECO:0000269|PubMed:24290141
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by ULK1, ULK2 and mTOR. Phosphorylation status depends on nutrient-rich conditions; dephosphorylated during starvation or following treatment with rapamycin. ULK1-mediated phosphorylation of ATG13 at Ser-355 is required for efficient clearance of depolarized mitochondria. {ECO:0000269|PubMed:18936157, ECO:0000269|PubMed:19211835, ECO:0000269|PubMed:19225151, ECO:0000269|PubMed:19287211, ECO:0000269|PubMed:21258367, ECO:0000269|PubMed:21855797}.
uniprot
proteins
protein_family
ATG13 family
uniprot
proteins
protein_family
Metazoan subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
18936157
uniprot
proteins
pubmed
19211835
uniprot
proteins
pubmed
19225151
uniprot
proteins
pubmed
19287211
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19597335
uniprot
proteins
pubmed
21258367
uniprot
proteins
pubmed
21795849
uniprot
proteins
pubmed
21855797
uniprot
proteins
pubmed
21976705
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23043107
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24290141
uniprot
proteins
pubmed
26236954
uniprot
proteins
pubmed
26299944
uniprot
proteins
pubmed
27334615
uniprot
proteins
pubmed
31806350
uniprot
proteins
pubmed
9734811
uniprot
proteins
sequence_length
517
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:19211835}. Preautophagosomal structure {ECO:0000269|PubMed:19211835}. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane; the isolation membrane sequesters a portion of the cytoplasm resulting in autophagosome formation. {ECO:0000269|PubMed:19211835}.
uniprot
proteins