Pou4f2
entrez
171355
canonical
uniprot
G3V7L5
canonical
ensembl
ENSRNOG00000012167
resolver
ensembl
ENSRNOG00055007993
resolver
ensembl
ENSRNOG00060013245
resolver
ensembl
ENSRNOG00065010001
resolver
ensp
ENSRNOP00000016422
resolver
ensp
ENSRNOP00055010790
resolver
ensp
ENSRNOP00060017901
resolver
ensp
ENSRNOP00065012177
resolver
enst
ENSRNOT00000016422
resolver
enst
ENSRNOT00055013469
resolver
enst
ENSRNOT00060022581
resolver
enst
ENSRNOT00065016080
resolver
genesymbol
Pou4f2
resolver
genesymbol_syn
Brn3b
resolver
uniprot_entry
PO4F2_RAT
resolver
amino_acid_sequence
MMMMSLNSKQAFSMPHAGSLHVEPKYSALHSASPGSSAPAAPSASSPSSSSNAGSGGGGGGGGGGGGGGRSSSSSSSGSGGGGGGGSEAMRRACLPTPPSNIFGGLDESLLARAEALAAVDIVSQSKSHHHHPPHHSPFKPDATYHTMNTIPCTSAASSSSVPISHPSALAGTHHHHHHHHHHHHQPHQALEGELLEHLSPGLALGAMAGPDGTVVSTPAHAPHMATMNPMHQAALSMAHAHGLPSHMGCMSDVDADPRDLEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEKSHREKLTKPELFNGAEKKRKRTSIAAPEKRSLEAYFAIQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKYSAGI
uniprot
proteins
function
FUNCTION: Tissue-specific DNA-binding transcription factor involved in the development and differentiation of target cells. Functions either as activator or repressor modulating the rate of target gene transcription through RNA polymerase II enzyme in a promoter-dependent manner. Binds to the consensus octamer motif 5'-AT[A/T]A[T/A]T[A/T]A-3' of promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to an octamer site to form a ternary complex with ISL1; cooperates positively with ISL1 and ISL2 to potentiate transcriptional activation of RGC target genes being involved in RGC fate commitment in the developing retina and RGC axon formation and pathfinding. Inhibits DLX1 and DLX2 transcriptional activities preventing DLX1- and DLX2-mediated ability to promote amacrine cell fate specification. In cooperation with TP53 potentiates transcriptional activation of BAX promoter activity increasing neuronal cell apoptosis. Negatively regulates BAX promoter activity in the absence of TP53. Acts as a transcriptional coactivator via its interaction with the transcription factor ESR1 by enhancing its effect on estrogen response element (ERE)-containing promoter. Antagonizes the transcriptional stimulatory activity of POU4F1 by preventing its binding to an octamer motif. Involved in TNFSF11-mediated terminal osteoclast differentiation. {ECO:0000250|UniProtKB:Q63934}.
uniprot
proteins
mass_dalton
43230
uniprot
proteins
protein_family
Class-4 subfamily
uniprot
proteins
protein_family
POU transcription factor family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
18368538
uniprot
proteins
pubmed
8835784
uniprot
proteins
sequence_length
412
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18368538}. Nucleus speckle {ECO:0000250|UniProtKB:Q12837}. Cytoplasm {ECO:0000250|UniProtKB:Q63934}.
uniprot
proteins