ADCY3
entrez
109
canonical
uniprot
O60266
canonical
ensembl
ENSG00000138031
resolver
ensp
ENSP00000260600
resolver
ensp
ENSP00000384484
resolver
ensp
ENSP00000475652
resolver
ensp
ENSP00000505261
resolver
ensp
ENSP00000537916
resolver
ensp
ENSP00000537917
resolver
ensp
ENSP00000537919
resolver
ensp
ENSP00000582271
resolver
ensp
ENSP00000618936
resolver
ensp
ENSP00000618942
resolver
enst
ENST00000405392
resolver
genesymbol
ADCY3
resolver
genesymbol_syn
KIAA0511
resolver
hgnc
HGNC:234
resolver
uniprot
A0A0A0MSC1
resolver
uniprot
B3KT86
resolver
uniprot
B7ZLX9
resolver
uniprot
Q53T54
resolver
uniprot
Q9UDB1
resolver
uniprot_entry
A0A0A0MSC1_HUMAN
resolver
uniprot_entry
ADCY3_HUMAN
resolver
uniprot_entry
B7ZLX9_HUMAN
resolver
uniprot_sec
B3KT86
resolver
uniprot_sec
Q53T54
resolver
uniprot_sec
Q9UDB1
resolver
activity_regulation
ACTIVITY REGULATION: Specifically activated by the G alpha protein GNAL/G(olf) in signaling cascades triggered by odorant receptors (By similarity). Specifically activated by the G alpha protein GNAS/G(s) in primary cilia (PubMed:29311635). Activated by forskolin (By similarity). After forskolin treatment, activity is further increased by calcium/calmodulin (By similarity). In the absence of forskolin, calcium/calmodulin has little effect on enzyme activity (By similarity). {ECO:0000250|UniProtKB:P21932, ECO:0000269|PubMed:29311635}.
uniprot
proteins
amino_acid_sequence
MPRNQGFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPESLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLASLAVAGIGLVLDIILFVLCKKGLLPDRVTRRVLPYVLWLLITAQIFSYLGLNFARAHAASDTVGWQVFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQEELKGMQLLREILANVFLYLCAIAVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLEEKGIETYLIIASKPEVKKTATQNGLNGSALPNGAPASSKSSSPALIETKEPNGSAHSSGSTSEKPEEQDAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFMVGEILLLILTICSLAAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMANVVDMLSCLQYYTGPSNATAGMETEGSCLENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVAGAVATINLYAWRPVFDEYDHKRFREHDLPMVALEQMQGFNPGLNGTDRLPLVPSKYSMTVMVFLMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQTYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFASSNKEDKSERERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDKLATFPNGPSVTLPHQVVDNS
uniprot
proteins
disease_involvement
DISEASE: Obesity (OBESITY) [MIM:601665]: A condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. {ECO:0000269|PubMed:29311636, ECO:0000269|PubMed:29311637, ECO:0000269|PubMed:37855273, ECO:0000269|PubMed:39519366}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
4.6.1.1
uniprot
proteins
function
FUNCTION: Catalyzes the formation of the signaling molecule cAMP in response to G protein signaling (PubMed:29311635). Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis: specifically activated by G alpha protein GNAL/G(olf) in olfactory epithelium (By similarity). Mediates signaling cascades in primary cilia: specifically activated by G alpha protein GNAS/G(s) in primary cilia (PubMed:29311635). Plays a role in regulating food intake and body fat accumulation in the paraventricular nucleus of the hypothalamus (PVH) by acting downstream of MC4R activation (PubMed:29311635). Required for normal sperm motility and normal male fertility (By similarity). {ECO:0000250|UniProtKB:Q8VHH7, ECO:0000269|PubMed:29311635}.
uniprot
proteins
mass_dalton
128960
uniprot
proteins
post_translational_modification
PTM: Sumoylated. Sumoylation is required for targeting to olfactory cilia. {ECO:0000250|UniProtKB:P21932}.; PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q8VHH7}.; PTM: Rapidly phosphorylated after stimulation by odorants or forskolin. Phosphorylation by CaMK2 at Ser-1076 down-regulates enzyme activity. {ECO:0000250|UniProtKB:Q8VHH7}.
uniprot
proteins
protein_family
Adenylyl cyclase class-4/guanylyl cyclase family
uniprot
proteins
pubmed
11549699
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15705663
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
29311635
uniprot
proteins
pubmed
29311636
uniprot
proteins
pubmed
29311637
uniprot
proteins
pubmed
37855273
uniprot
proteins
pubmed
39519366
uniprot
proteins
pubmed
8476432
uniprot
proteins
pubmed
9628581
uniprot
proteins
pubmed
9920776
uniprot
proteins
sequence_length
1144
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11549699}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium membrane {ECO:0000269|PubMed:29311635}; Multi-pass membrane protein. Cell projection, cilium {ECO:0000250|UniProtKB:Q8VHH7}. Cytoplasm {ECO:0000269|PubMed:11549699}. Golgi apparatus {ECO:0000250|UniProtKB:P21932}. Note=Also detected in the cytoplasm, close to lipid droplets. {ECO:0000269|PubMed:11549699}.
uniprot
proteins
transmembrane_region
TRANSMEM 80..100; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 105..125; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 139..159; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 173..193; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 226..246; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 381..401; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 633..653; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 664..684; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 708..728; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 754..774; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 775..795; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 833..853; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins