Erfe
entrez
681056
canonical
uniprot
D4AB34
canonical
ensembl
ENSRNOG00000024688
resolver
ensembl
ENSRNOG00055009467
resolver
ensembl
ENSRNOG00060008604
resolver
ensembl
ENSRNOG00065021144
resolver
ensp
ENSRNOP00000045074
resolver
ensp
ENSRNOP00055012830
resolver
ensp
ENSRNOP00060011022
resolver
ensp
ENSRNOP00065028976
resolver
enst
ENSRNOT00000051810
resolver
enst
ENSRNOT00055015991
resolver
enst
ENSRNOT00060014350
resolver
enst
ENSRNOT00065035938
resolver
genesymbol
Erfe
resolver
genesymbol_syn
C1qtnf15
resolver
genesymbol_syn
Ctrp15
resolver
genesymbol_syn
Fam132b
resolver
uniprot_entry
ERFE_RAT
resolver
amino_acid_sequence
MASTRSPGGARTLLACASLLAAMGLGVPESAEPVGTQARPQPPGTELPAPPAHSPPEPTIAHAHSVDPRDAWMLFVKQSDKGINSKKRSRTKARRLKLGLPGPPGPPGPQGPPGPFIPSEVLLKEFQLLLKGAVRQRESTEHCTRDLTTPASGGPSRDPVTQELESQDQGAVLALLAATLAQSPRAPRVEAAFHCRLRRDVQVERRALHELGVYYLPEVEGAFRRGPGLNLTSGQYTAPVAGFYALAATLHVALTKQPRKGPPQPRDRLRLLICIQSLCQHNASLETVMGLENSSELFTISVNGVLYLQTGHYTSVFLDNASGSSLTVRGGSHFSAILLGL
uniprot
proteins
function
FUNCTION: Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores (By similarity). Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake (PubMed:22351773). Inhibits apoptosis and inflammatory response in cardiomyocytes via promotion of sphingosine-1-phosphate (S1P) and cAMP-dependent activation of AKT signaling (PubMed:30566056). Inhibits autophagy induced by nutrient deficiency in hepatocytes via promoting the phosphorylation of IRS1, AKT, and MTOR, and thereby subsequent activation of the AKT-MTOR signaling pathway (PubMed:24187137). Negatively regulates the differentiation of osteoblasts, potentially via sequestering BMP2, and thereby inhibits the activation of SMAD signaling (By similarity). The reduction in BMP2 signaling in osteoblasts also results in an increase in expression of the osteoclastogenesis-promoting factors TNFSF11/RANKL and SOST, thereby indirectly promotes bone resorption (By similarity). {ECO:0000250|UniProtKB:Q6PGN1, ECO:0000269|PubMed:22351773, ECO:0000269|PubMed:24187137, ECO:0000269|PubMed:30566056}.
uniprot
proteins
mass_dalton
36369
uniprot
proteins
post_translational_modification
PTM: N-glycosylated; required for secretion of the mature protein. {ECO:0000250|UniProtKB:Q6PGN1}.
uniprot
proteins
protein_family
Adipolin/erythroferrone family
uniprot
proteins
pubmed
22351773
uniprot
proteins
pubmed
24187137
uniprot
proteins
pubmed
30566056
uniprot
proteins
sequence_length
341
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q6PGN1}. Note=Secreted when glycosylated at Asn-230 and Asn-282 (By similarity). Hydroxylation promotes secretion (By similarity). {ECO:0000250|UniProtKB:Q6PGN1}.
uniprot
proteins