NOXO1
entrez
124056
canonical
uniprot
Q8NFA2
canonical
ensembl
ENSG00000196408
resolver
ensembl
ENSG00000291939
resolver
ensp
ENSP00000346195
resolver
ensp
ENSP00000348435
resolver
ensp
ENSP00000380450
resolver
ensp
ENSP00000456800
resolver
genesymbol
NOXO1
resolver
genesymbol_syn
P41NOX
resolver
genesymbol_syn
SH3PXD5
resolver
hgnc
HGNC:19404
resolver
uniprot
A8K832
resolver
uniprot
Q86YM1
resolver
uniprot
Q8NFA3
resolver
uniprot
Q96B73
resolver
uniprot_entry
A8K832_HUMAN
resolver
uniprot_entry
NOXO1_HUMAN
resolver
uniprot_sec
Q86YM1
resolver
uniprot_sec
Q8NFA3
resolver
uniprot_sec
Q96B73
resolver
amino_acid_sequence
MAGPRYPVSVQGAALVQIKRLQTFAFSVRWSDGSDTFVRRSWDEFRQLKKTLKETFPVEAGLLRRSDRVLPKLLGQASLDAPLLGRVGRTSRGLARLQLLETYSRRLLATAERVARSPTITGFFAPQPLDLEPALPPGSRVILPTPEEQPLSRAAGRLSIHSLEAQSLRCLQPFCTQDTRDRPFQAQAQESLDVLLRHPSGWWLVENEDRQTAWFPAPYLEEAAPGQGREGGPSLGSSGPQFCASRAYESSRADELSVPAGARVRVLETSDRGWWLCRYGDRAGLLPAVLLRPEGLGALLSGTGFRGGDDPAGEARGFPEPSQATAPPPTVPTRPSPGAIQSRCCTVTRRALERRPRRQGRPRGCVDSVPHPTTEQ
uniprot
proteins
function
FUNCTION: Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. {ECO:0000269|PubMed:12657628, ECO:0000269|PubMed:14617635, ECO:0000269|PubMed:15326186, ECO:0000269|PubMed:15824103, ECO:0000269|PubMed:15949904, ECO:0000269|PubMed:16329988, ECO:0000269|PubMed:17126813, ECO:0000269|PubMed:19755710}.
uniprot
proteins
mass_dalton
41253
uniprot
proteins
mutagenesis
MUTAGEN 40; /note="R->Q: Loss of ability to activate NOX1 associated with loss of lipid-binding and plasma membrane localization."; /evidence="ECO:0000269|PubMed:14617635"; MUTAGEN 202; /note="W->R: Loss of ability to activate NOX3 and interact with CYBA. Induces interaction with NOXA1 in vitro."; /evidence="ECO:0000269|PubMed:15824103, ECO:0000269|PubMed:17126813"; MUTAGEN 274; /note="W->R: Induces interaction with NOXA1 in vitro."; /evidence="ECO:0000269|PubMed:17126813"; MUTAGEN 332; /note="P->A: Loss of intramolecular interaction."; /evidence="ECO:0000269|PubMed:17126813"; MUTAGEN 334; /note="R->A: Loss of intramolecular interaction."; /evidence="ECO:0000269|PubMed:17126813
uniprot
proteins
pubmed
12473664
uniprot
proteins
pubmed
12657628
uniprot
proteins
pubmed
12716910
uniprot
proteins
pubmed
14617635
uniprot
proteins
pubmed
15326186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15824103
uniprot
proteins
pubmed
15949904
uniprot
proteins
pubmed
16329988
uniprot
proteins
pubmed
17126813
uniprot
proteins
pubmed
19755710
uniprot
proteins
pubmed
20609497
uniprot
proteins
sequence_length
376
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane {ECO:0000269|PubMed:12716910}; Peripheral membrane protein {ECO:0000269|PubMed:12716910}; Cytoplasmic side {ECO:0000269|PubMed:12716910}. Note=Isoform 3 associates with the plasma membrane in a lipid-dependent manner (PubMed:12716910).
uniprot
proteins