Sfrp4
entrez
20379
canonical
uniprot
Q9Z1N6
canonical
ensembl
ENSMUSG00000021319
resolver
ensp
ENSMUSP00000002883
resolver
enst
ENSMUST00000002883
resolver
genesymbol
Sfrp4
resolver
uniprot
Q91ZX9
resolver
uniprot_entry
SFRP4_MOUSE
resolver
uniprot_sec
Q91ZX9
resolver
amino_acid_sequence
MLRSILVALCLWLRLALGVRGAPCEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIEQYEELVDVNCSSVLRFFLCAMYAPICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELPVYDRGVCISPEAIVTDLPEDVKWIDITPDMMVQERSFDADCKRLSPDRCKCKKVKPTLATYLSKNYSYVIHAKIKAVQRSGCNEVTTVVDVKEIFKSLSPIPRTQVPLITNSSCQCPHILPHQDVLIMCYEWRSRMMLLENCLVEKWRDQLSRRSIQWEERLQEQQRTIQDKKQIASRTSRTSRSNPPKSKGRPPAPKPASPKKNIKARSAPKKSNLKKSAS
uniprot
proteins
function
FUNCTION: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types (PubMed:27355534). SFRP4 plays a role in bone morphogenesis (PubMed:27355534). May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling (By similarity). Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake (By similarity). {ECO:0000250|UniProtKB:Q6FHJ7, ECO:0000250|UniProtKB:Q9JLS4, ECO:0000269|PubMed:27355534}.
uniprot
proteins
mass_dalton
40342
uniprot
proteins
protein_family
Secreted frizzled-related protein (sFRP) family
uniprot
proteins
pubmed
10072424
uniprot
proteins
pubmed
11485313
uniprot
proteins
pubmed
12960062
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
27355534
uniprot
proteins
pubmed
9096311
uniprot
proteins
pubmed
9739103
uniprot
proteins
sequence_length
351
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q6FHJ7}.
uniprot
proteins