Il4
entrez
16189
canonical
uniprot
P07750
canonical
ensembl
ENSMUSG00000000869
resolver
ensp
ENSMUSP00000000889
resolver
enst
ENSMUST00000000889
resolver
genesymbol
Il4
resolver
genesymbol_syn
Il-4
resolver
uniprot_entry
IL4_MOUSE
resolver
amino_acid_sequence
MGLNPQLVVILLFFLECTRSHIHGCDKNHLREIIGILNEVTGEGTPCTEMDVPNVLTATKNTTESELVCRASKVLRIFYLKHGKTPCLKKNSSVLMELQRLFRAFRCLDSSISCTMNESKSTSLKDFLESLKSIMQMDYS
uniprot
proteins
function
FUNCTION: Cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses (PubMed:3083412). Induces the expression of class II MHC molecules on resting B-cells (PubMed:3498301). Enhances both secretion and cell surface expression of IgE and IgG1 (PubMed:3498301). Also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes (By similarity). Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4 (PubMed:26416964). In addition, plays a critical role in higher functions of the normal brain, such as memory and learning (PubMed:25772794, PubMed:28202615). Upon binding to IL4, IL4R receptor dimerizes either with the common IL2R gamma chain/IL2RG to produce the type 1 signaling complex, located mainly on hematopoietic cells, or with the IL13RA1 to produce the type 2 complex, which is also expressed on nonhematopoietic cells. Engagement of both types of receptors initiates JAK3 and to a lower extend JAK1 phosphorylation leading to activation of the signal transducer and activator of transcription 6/STAT6 (PubMed:25847241, PubMed:8624821). {ECO:0000250|UniProtKB:P05112, ECO:0000269|PubMed:25772794, ECO:0000269|PubMed:25847241, ECO:0000269|PubMed:28202615, ECO:0000269|PubMed:3083412, ECO:0000269|PubMed:3498301, ECO:0000269|PubMed:8624821}.
uniprot
proteins
mass_dalton
15834
uniprot
proteins
protein_family
IL-4/IL-13 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1993171
uniprot
proteins
pubmed
25772794
uniprot
proteins
pubmed
25847241
uniprot
proteins
pubmed
26416964
uniprot
proteins
pubmed
28202615
uniprot
proteins
pubmed
3005865
uniprot
proteins
pubmed
3029676
uniprot
proteins
pubmed
3083412
uniprot
proteins
pubmed
3498301
uniprot
proteins
pubmed
8624821
uniprot
proteins
sequence_length
140
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins