Lhx3
entrez
16871
canonical
uniprot
P50481
canonical
ensembl
ENSMUSG00000026934
resolver
ensp
ENSMUSP00000028302
resolver
ensp
ENSMUSP00000056822
resolver
genesymbol
Lhx3
resolver
genesymbol_syn
Lim-3
resolver
genesymbol_syn
Lim3
resolver
genesymbol_syn
Plim
resolver
uniprot
A2ALD8
resolver
uniprot
A2ALD9
resolver
uniprot
Q61800
resolver
uniprot
Q61801
resolver
uniprot_entry
A2ALD8_MOUSE
resolver
uniprot_entry
LHX3_MOUSE
resolver
uniprot_sec
A2ALD9
resolver
uniprot_sec
Q61800
resolver
uniprot_sec
Q61801
resolver
amino_acid_sequence
MLLEAELDCHRERPGAPGASALCTFSRTPEIPMCAGCDQHILDRFILKALDRHWHSKCLKCSDCHVPLAERCFSRGESVYCKDDFFKRFGTKCAACQLGIPPTQVVRRAQDFVYHLHCFACVVCKRQLATGDEFYLMEDSRLVCKADYETAKQREAEATAKRPRTTITAKQLETLKSAYNTSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRQRWGQYFRNMKRSRGSSKSDKDSIQEGQDSDAEVSFTDEPSMADMGPANGLYSSLGEPAPALGRPVGGLGSFTLDHGGLTGPEQYRELRPGSPYGIPPSPAAPQSLPGPQPLLSSLVYPDTNLSLVPSGPPGGPPPMRVLAGNGPSSDLSTESSSGYPDFPASPASWLDEVDHAQF
uniprot
proteins
function
FUNCTION: Transcription factor (PubMed:10593900, PubMed:12150931, PubMed:18539116). Recognizes and binds to the consensus sequence motif 5'-AATTAATTA-3' in the regulatory elements of target genes, such as glycoprotein hormones alpha chain CGA and visual system homeobox CHX10, positively modulating transcription; transcription can be co-activated by LDB2 (PubMed:10593900, PubMed:18539116, PubMed:9192866). Synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (PubMed:7708713). Required for the establishment of the specialized cells of the pituitary gland and the nervous system (By similarity). Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1 (PubMed:12150931, PubMed:18539116). {ECO:0000250|UniProtKB:Q9UBR4, ECO:0000269|PubMed:10593900, ECO:0000269|PubMed:12150931, ECO:0000269|PubMed:18539116, ECO:0000269|PubMed:7708713, ECO:0000269|PubMed:9192866}.
uniprot
proteins
mass_dalton
44010
uniprot
proteins
pubmed
10593900
uniprot
proteins
pubmed
12150931
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18539116
uniprot
proteins
pubmed
18583962
uniprot
proteins
pubmed
7626792
uniprot
proteins
pubmed
7708713
uniprot
proteins
pubmed
7811383
uniprot
proteins
pubmed
9192866
uniprot
proteins
sequence_length
400
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins