SF3A2
entrez
8175
canonical
uniprot
Q15428
canonical
ensembl
ENSG00000104897
resolver
ensp
ENSP00000221494
resolver
ensp
ENSP00000536989
resolver
ensp
ENSP00000536990
resolver
ensp
ENSP00000536992
resolver
ensp
ENSP00000581716
resolver
ensp
ENSP00000581717
resolver
enst
ENST00000221494
resolver
enst
ENST00000866930
resolver
enst
ENST00000866931
resolver
enst
ENST00000866933
resolver
enst
ENST00000911657
resolver
enst
ENST00000911658
resolver
genesymbol
SF3A2
resolver
genesymbol_syn
SAP62
resolver
hgnc
HGNC:10766
resolver
uniprot
B2RBU1
resolver
uniprot
D6W605
resolver
uniprot
O75245
resolver
uniprot
Q05DF2
resolver
uniprot_entry
Q05DF2_HUMAN
resolver
uniprot_entry
SF3A2_HUMAN
resolver
uniprot_sec
B2RBU1
resolver
uniprot_sec
D6W605
resolver
uniprot_sec
O75245
resolver
amino_acid_sequence
MDFQHRPGGKTGSGGVASSSESNRDRRERLRQLALETIDINKDPYFMKNHLGSYECKLCLTLHNNEGSYLAHTQGKKHQTNLARRAAKEAKEAPAQPAPEKVKVEVKKFVKIGRPGYKVTKQRDSEMGQQSLLFQIDYPEIAEGIMPRHRFMSAYEQRIEPPDRRWQYLLMAAEPYETIAFKVPSREIDKAEGKFWTHWNRETKQFFLQFHFKMEKPPAPPSLPAGPPGVKRPPPPLMNGLPPRPPLPESLPPPPPGGLPLPPMPPTGPAPSGPPGPPQLPPPAPGVHPPAPVVHPPASGVHPPAPGVHPPAPGVHPPAPGVHPPTSGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPPSAGVHPQAPGVHPAAPAVHPQAPGVHPPAPGMHPQAPGVHPQPPGVHPSAPGVHPQPPGVHPSNPGVHPPTPMPPMLRPPLPSEGPGNIPPPPPTN
uniprot
proteins
function
FUNCTION: Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:10882114, PubMed:11533230, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, SF3A2 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex (PubMed:10882114, PubMed:11533230). Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes, including the Bact complex (PubMed:29360106, PubMed:29361316, PubMed:30315277). Interacts directly with the duplex formed by U2 snRNA and the intron (PubMed:29360106). {ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:11533230, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277, ECO:0000269|PubMed:32494006, ECO:0000269|PubMed:34822310}.
uniprot
proteins
mass_dalton
49256
uniprot
proteins
protein_family
SF3A2 family
uniprot
proteins
pubmed
10882114
uniprot
proteins
pubmed
11533230
uniprot
proteins
pubmed
11991638
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21349847
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
29360106
uniprot
proteins
pubmed
29361316
uniprot
proteins
pubmed
30315277
uniprot
proteins
pubmed
32494006
uniprot
proteins
pubmed
34822310
uniprot
proteins
pubmed
36797247
uniprot
proteins
pubmed
8211113
uniprot
proteins
pubmed
9710584
uniprot
proteins
sequence_length
464
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00130, ECO:0000269|PubMed:10882114, ECO:0000269|PubMed:21349847, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:29361316, ECO:0000269|PubMed:30315277}.
uniprot
proteins