Ppp1r12a
entrez
116670
canonical
uniprot
Q10728
canonical
ensembl
ENSRNOG00000004925
resolver
ensp
ENSRNOP00000040934
resolver
ensp
ENSRNOP00000045260
resolver
ensp
ENSRNOP00000069900
resolver
ensp
ENSRNOP00000078058
resolver
ensp
ENSRNOP00000104388
resolver
enst
ENSRNOT00000041473
resolver
enst
ENSRNOT00000050037
resolver
enst
ENSRNOT00000080285
resolver
enst
ENSRNOT00000108069
resolver
enst
ENSRNOT00000152362
resolver
genesymbol
Ppp1r12a
resolver
genesymbol_syn
Mbs
resolver
genesymbol_syn
Mypt1
resolver
uniprot
A0A0G2JWJ0
resolver
uniprot
A0A8I5Y8E5
resolver
uniprot
A0ABK0LSN2
resolver
uniprot
D4A1S6
resolver
uniprot
D4ACS0
resolver
uniprot
Q62937
resolver
uniprot
Q9WU33
resolver
uniprot_entry
A0A0G2JWJ0_RAT
resolver
uniprot_entry
A0A8I5Y8E5_RAT
resolver
uniprot_entry
A0ABK0LSN2_RAT
resolver
uniprot_entry
D4ACS0_RAT
resolver
uniprot_entry
MYPT1_RAT
resolver
uniprot_sec
D4A1S6
resolver
uniprot_sec
Q62937
resolver
uniprot_sec
Q9WU33
resolver
amino_acid_sequence
MKMADAKQKRNEQLKRWIGSETDLEPPVVKRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHISDVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMETVNKVGQTAFDVADEDILGYLEELQKKQNLLHSEKRDKKSPLIESTANMENNQPQKTFKNKETLIIEPEKNASRIESLEQEKADEEEEGKKDESSCSSEEDEEDDSESEAETDKTKPMASVTNAHTASTQAAPAAVTTPTLSSNQGTPTSPVKKFPTSTTKISPKEEERKDESPASWRLGLRKTGSYGALAEITASKEAQKEKDTAGVIRSASSPRLSSSLDNKEKEKDNKGTRLAYVAPTIPRRLGSTSDIEEKENRESSNLRTSSSYTRRKWEDDLKKNSSINEGSTYHRSCSFGRRQDDLISCSVPSTTSTPTVTSAAGLQKSFLSSTSTTAKTPPGSSPAGTQSSTSNRLWAEDSTEKEKDSAPTAATILVAPTVVSAAASSTTALTTTTAGTLSSTSEVRERRRSYLTPVRDEESESQRKARSRQARQSRRSTQGVTLTDLQEAEKTIGRSRSTRTREQENEEKDKEEKEKQDKEKQEEKKESEVSREDEYKQKYSRTYDETYARYRPVSTSSSSTPSSSSLSTLGSSLYASSQLNRPNSLVGITSAYSRGLTKDNEREGEKKEEEKEGEDKSQPKSIRERRRPREKRRSTGVSFWTQDSDENEQERQSDTEDGSSKRDTQTDSVSRYDSSSTSSSDRYDSLLGRSASYSYLEERKPYGSRLEKDDSTDFKKLYEQILAENEKLKAQLHDTNMELTDLKLQLEKATQRQERFADRSLLEMEKRERRALERRISEMEEELKMLPDLKADNQRLKDENGALIRVISKLSK
uniprot
proteins
function
FUNCTION: Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity (By similarity). {ECO:0000250|UniProtKB:O14974, ECO:0000269|PubMed:8543033}.
uniprot
proteins
mass_dalton
115283
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on upon DNA damage, probably by ATM or ATR (By similarity). Phosphorylated by CIT (Rho-associated kinase). Phosphorylated cooperatively by ROCK1 and CDC42BP on Thr-697. In vitro, phosphorylation of Ser-696 by PKA and PKG appears to prevent phosphorylation of the inhibitory site Thr-697, probably mediated by PRKG1 (By similarity). May be phosphorylated at Thr-697 by DMPK; may inhibit the myosin phosphatase activity. Phosphorylated at Ser-473 by CDK1 during mitosis, creating docking sites for the POLO box domains of PLK1. Subsequently, PLK1 binds and phosphorylates PPP1R12A (By similarity). {ECO:0000250|UniProtKB:O14974}.
uniprot
proteins
pubmed
10579722
uniprot
proteins
pubmed
10712248
uniprot
proteins
pubmed
11384979
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
19131646
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7988720
uniprot
proteins
pubmed
8543033
uniprot
proteins
pubmed
8662509
uniprot
proteins
sequence_length
1032
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O14974}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:O14974}. Note=Also along actomyosin filaments. {ECO:0000250|UniProtKB:O14974}.
uniprot
proteins