Adgrb1
entrez
362931
canonical
uniprot
C0HL12
canonical
ensembl
ENSRNOG00000029450
resolver
ensp
ENSRNOP00000077654
resolver
ensp
ENSRNOP00000096011
resolver
enst
ENSRNOT00000076127
resolver
genesymbol
Adgrb1
resolver
genesymbol_syn
AABR07058422.1
resolver
genesymbol_syn
Bai1
resolver
uniprot
A0A8I5Y6L4
resolver
uniprot_entry
A0A8I5Y6L4_RAT
resolver
uniprot_entry
AGRB1_RAT
resolver
amino_acid_sequence
MRGQAAAPGPIWILAPLLLLLLLLGRWARAASGADIGPGTEQCTTLVQGKFFGYFSAAAVFPANASRCSWTLRNPDPRRYTLYMKVAKAPAPCSGPGRVRTYQFDSFLESTRTYLGVESFDEVLRLCDPSAPLAFLQASKQFLQMQRQQPPQDGDLGPQGSGDDFSVEYLVVGNRNPSHAACQMLCRWLDACLAGSRSSHPCGIMQTPCACLGGEAGDTASSPLVPRGDVCLRDGVAGGPENCLTSLTQDRGGHGSAGGWKLWSLWGECTRDCGGGLQTRTRTCSPTLGVEGRGCEGVLEEGRLCNRKACGPTGRTSSRSQSLRSTDARRREEFGDELQQFGFPSPQTGDPAAEEWSPWSVCSSTCGEGWQTRTRFCVSSSYSTQCSGPLREQRLCNNSAVCPVHGAWDEWSPWSLCSSTCGRGFRDRTRTCRPPQFGGNPCEGPEKQTKFCNIALCPGRAVDGNWNEWSSWSTCSASCSQGRQQRTRECNGPSYGGAECQGHWVETRDCFLQQCPVDGKWQAWASWGSCSVTCGGGSQRRERVCSGPFFGGAACQGPQDEYRQCGAQRCPEPHEICDEDNFGAVVWKETPAGEVAAVRCPRNATGLILRRCELDEEGIAFWEPPTYIRCVSIDYRNIQMMTREHLAKAQRGLPGEGVSEVIQTLLEISQDGTSYSGDLLSTIDVLRNMTEIFRRAYYSPTPGDVQNFVQIISNLLAEENRDKWEEAQLMGPNAKELFRLVEDFVDVIGFRMKDLRDAYQVTDNLVLSIHKLPASGATDISFPMKGWRATGDWAKVPEDRVTVSKSVFSTGLAEADDSSVFVVGTVLYRNLGSFLALQRNTTVLNSKVISVTVKPPPRSLLTPLEIEFAHMYNGTTNQTCILWDETDGPSSSAPPQLGPWSWRGCRTVPLDALRTRCLCDRLSTFAILAQLSADATMDKVTVPSVTLIVGCGVSSLTLLMLVIIYVSVWRYIRSERSVILINFCLSIISSNALILIGQTQTRNKVVCTLVAAFLHFFFLSSFCWVLTEAWQSYMAVTGRLRSRLVRKRFLCLGWGLPALVVAISVGFTKAKGYSTMNYCWLSLEGGLLYAFVGPAAAVVLVNMVIGILVFNKLVSKDGITDKKLKERAGASLWSSCVVLPLLALTWMSAVLAVTDRRSALFQILFAVFDSLEGFVIVMVHCILRREVQDAVKCRVVDRQEEGNGDSGGSFQNGHAQLMTDFEKDVDLACRSVLNKDIAACRTATITGTFKRPSLPEEEKMKLAKGPPPTFNSLPANVSKLHLHGSPRYPGGPLPDFPNHSLTLKKDKAPKSSFIGDGDIFKKLDSELSRAQEKALDTSYVILPTATATLRPKPKEEPKYSINIDQMPQTRLIHLSMAPDASFPTRSPPAREPPGGAPPEVPPVQPPPPPPPPPPPQQPIPPPPSLEPAPPSLGDTGEPSAHPGPSSGAGTKNENVATLSVSSLERRKSRYAELDFEKIMHTRKRHQDMFQDLNRKLQHAAEKEKEVPGVDNKPEKQQTPNKRAWESLRKPHGTPAWVKKELEPLPPSPLELRSVEWEKAGATIPLVGQDIIDLQTEV
uniprot
proteins
function
FUNCTION: Phosphatidylserine receptor which enhances the engulfment of apoptotic cells (By similarity). Also mediates the binding and engulfment of Gram-negative bacteria (By similarity). Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity (By similarity). In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells (By similarity). Promotes myoblast fusion (By similarity). Activates the Rho pathway in a G protein-dependent manner (By similarity). Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity (By similarity). Required for the formation of dendritic spines by ensuring the correct dendritic localization of PARD3 and TIAM1 (PubMed:23595754). Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma (By similarity). {ECO:0000250|UniProtKB:O14514, ECO:0000269|PubMed:23595754}.; FUNCTION: [Vasculostatin-120]: Inhibits angiogenesis in a CD36-dependent manner. {ECO:0000250|UniProtKB:O14514}.; FUNCTION: [Vasculostatin-40]: Inhibits angiogenesis. {ECO:0000250|UniProtKB:O14514}.
uniprot
proteins
mass_dalton
172883
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved to produce vasculostatin-40 and vasculostatin-120. Vasculostatin-40 is the major form and is produced through proteolytic cleavage by MMP14 between residues 317 and 325 with cleavage likely to be between Ser-322 and Leu-323. {ECO:0000250|UniProtKB:O14514}.; PTM: Ubiquitinated. {ECO:0000250|UniProtKB:O14514}.
uniprot
proteins
protein_family
G protein-coupled receptor 2 family
uniprot
proteins
protein_family
LN-TM7 subfamily
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23595754
uniprot
proteins
sequence_length
1577
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O14514}; Multi-pass membrane protein {ECO:0000255}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:Q3UHD1}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q3UHD1}. Cell projection, dendritic spine {ECO:0000269|PubMed:23595754}. Postsynaptic density {ECO:0000269|PubMed:23595754}.; SUBCELLULAR LOCATION: [Vasculostatin-120]: Secreted {ECO:0000250|UniProtKB:O14514}.; SUBCELLULAR LOCATION: [Vasculostatin-40]: Secreted {ECO:0000250|UniProtKB:O14514}.
uniprot
proteins
transmembrane_region
TRANSMEM 945..965; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 977..997; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 1005..1025; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 1049..1069; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 1090..1110; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 1133..1153; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 1163..1183; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins