MORF4L2
entrez
9643
canonical
uniprot
Q15014
canonical
ensembl
ENSG00000123562
resolver
ensp
ENSP00000353643
resolver
ensp
ENSP00000391969
resolver
ensp
ENSP00000410532
resolver
ensp
ENSP00000415476
resolver
ensp
ENSP00000578370
resolver
ensp
ENSP00000578371
resolver
ensp
ENSP00000578372
resolver
ensp
ENSP00000578373
resolver
ensp
ENSP00000578374
resolver
ensp
ENSP00000578375
resolver
ensp
ENSP00000578376
resolver
ensp
ENSP00000578377
resolver
ensp
ENSP00000578378
resolver
ensp
ENSP00000578379
resolver
ensp
ENSP00000578380
resolver
ensp
ENSP00000578381
resolver
ensp
ENSP00000578382
resolver
ensp
ENSP00000578383
resolver
ensp
ENSP00000578384
resolver
ensp
ENSP00000578385
resolver
ensp
ENSP00000578386
resolver
ensp
ENSP00000578387
resolver
ensp
ENSP00000578388
resolver
ensp
ENSP00000578389
resolver
ensp
ENSP00000578390
resolver
ensp
ENSP00000578391
resolver
ensp
ENSP00000578392
resolver
ensp
ENSP00000578393
resolver
ensp
ENSP00000578394
resolver
ensp
ENSP00000578395
resolver
ensp
ENSP00000578396
resolver
ensp
ENSP00000578397
resolver
ensp
ENSP00000578398
resolver
ensp
ENSP00000578399
resolver
ensp
ENSP00000578400
resolver
ensp
ENSP00000578401
resolver
ensp
ENSP00000578402
resolver
ensp
ENSP00000578403
resolver
ensp
ENSP00000578404
resolver
ensp
ENSP00000588843
resolver
ensp
ENSP00000588844
resolver
ensp
ENSP00000588845
resolver
ensp
ENSP00000588846
resolver
ensp
ENSP00000588847
resolver
ensp
ENSP00000588848
resolver
ensp
ENSP00000588849
resolver
ensp
ENSP00000588850
resolver
ensp
ENSP00000588851
resolver
ensp
ENSP00000588852
resolver
ensp
ENSP00000588853
resolver
ensp
ENSP00000588854
resolver
ensp
ENSP00000588855
resolver
ensp
ENSP00000588856
resolver
ensp
ENSP00000588857
resolver
ensp
ENSP00000588858
resolver
ensp
ENSP00000588859
resolver
ensp
ENSP00000588860
resolver
ensp
ENSP00000588861
resolver
ensp
ENSP00000588862
resolver
ensp
ENSP00000588863
resolver
ensp
ENSP00000588864
resolver
ensp
ENSP00000588865
resolver
ensp
ENSP00000588866
resolver
ensp
ENSP00000588867
resolver
ensp
ENSP00000588868
resolver
ensp
ENSP00000588869
resolver
ensp
ENSP00000588870
resolver
ensp
ENSP00000588871
resolver
ensp
ENSP00000588872
resolver
ensp
ENSP00000588873
resolver
ensp
ENSP00000588874
resolver
ensp
ENSP00000588875
resolver
ensp
ENSP00000588876
resolver
ensp
ENSP00000588877
resolver
ensp
ENSP00000588878
resolver
ensp
ENSP00000588879
resolver
ensp
ENSP00000640706
resolver
ensp
ENSP00000640707
resolver
ensp
ENSP00000640708
resolver
ensp
ENSP00000640709
resolver
ensp
ENSP00000640710
resolver
ensp
ENSP00000640711
resolver
ensp
ENSP00000640712
resolver
ensp
ENSP00000640713
resolver
ensp
ENSP00000640714
resolver
ensp
ENSP00000640715
resolver
ensp
ENSP00000640716
resolver
ensp
ENSP00000640717
resolver
enst
ENST00000360458
resolver
enst
ENST00000433176
resolver
enst
ENST00000441076
resolver
enst
ENST00000451301
resolver
enst
ENST00000908311
resolver
enst
ENST00000908312
resolver
enst
ENST00000908313
resolver
enst
ENST00000908314
resolver
enst
ENST00000908315
resolver
enst
ENST00000908316
resolver
enst
ENST00000908317
resolver
enst
ENST00000908318
resolver
enst
ENST00000908319
resolver
enst
ENST00000908320
resolver
enst
ENST00000908321
resolver
enst
ENST00000908322
resolver
enst
ENST00000908323
resolver
enst
ENST00000908324
resolver
enst
ENST00000908325
resolver
enst
ENST00000908326
resolver
enst
ENST00000908327
resolver
enst
ENST00000908328
resolver
enst
ENST00000908329
resolver
enst
ENST00000908330
resolver
enst
ENST00000908331
resolver
enst
ENST00000908332
resolver
enst
ENST00000908333
resolver
enst
ENST00000908334
resolver
enst
ENST00000908335
resolver
enst
ENST00000908336
resolver
enst
ENST00000908337
resolver
enst
ENST00000908338
resolver
enst
ENST00000908339
resolver
enst
ENST00000908340
resolver
enst
ENST00000908341
resolver
enst
ENST00000908342
resolver
enst
ENST00000908343
resolver
enst
ENST00000908344
resolver
enst
ENST00000908345
resolver
enst
ENST00000918784
resolver
enst
ENST00000918785
resolver
enst
ENST00000918786
resolver
enst
ENST00000918787
resolver
enst
ENST00000918788
resolver
enst
ENST00000918789
resolver
enst
ENST00000918790
resolver
enst
ENST00000918791
resolver
enst
ENST00000918792
resolver
enst
ENST00000918793
resolver
enst
ENST00000918794
resolver
enst
ENST00000918795
resolver
enst
ENST00000918796
resolver
enst
ENST00000918797
resolver
enst
ENST00000918798
resolver
enst
ENST00000918799
resolver
enst
ENST00000918800
resolver
enst
ENST00000918801
resolver
enst
ENST00000918802
resolver
enst
ENST00000918803
resolver
enst
ENST00000918804
resolver
enst
ENST00000918805
resolver
enst
ENST00000918806
resolver
enst
ENST00000918807
resolver
enst
ENST00000918808
resolver
enst
ENST00000918809
resolver
enst
ENST00000918810
resolver
enst
ENST00000918811
resolver
enst
ENST00000918812
resolver
enst
ENST00000918813
resolver
enst
ENST00000918814
resolver
enst
ENST00000918815
resolver
enst
ENST00000918816
resolver
enst
ENST00000918817
resolver
enst
ENST00000918818
resolver
enst
ENST00000918819
resolver
enst
ENST00000918820
resolver
enst
ENST00000970647
resolver
enst
ENST00000970648
resolver
enst
ENST00000970649
resolver
enst
ENST00000970650
resolver
enst
ENST00000970651
resolver
enst
ENST00000970652
resolver
enst
ENST00000970653
resolver
enst
ENST00000970654
resolver
enst
ENST00000970655
resolver
enst
ENST00000970656
resolver
enst
ENST00000970657
resolver
enst
ENST00000970658
resolver
genesymbol
MORF4L2
resolver
genesymbol_syn
KIAA0026
resolver
genesymbol_syn
MRGX
resolver
hgnc
HGNC:16849
resolver
uniprot
B3KP92
resolver
uniprot
D3DXA5
resolver
uniprot
Q567V0
resolver
uniprot
Q8J026
resolver
uniprot_entry
MO4L2_HUMAN
resolver
uniprot_sec
B3KP92
resolver
uniprot_sec
D3DXA5
resolver
uniprot_sec
Q567V0
resolver
uniprot_sec
Q8J026
resolver
amino_acid_sequence
MSSRKQGSQPRGQQSAEEENFKKPTRSNMQRSKMRGASSGKKTAGPQQKNLEPALPGRWGGRSAENPPSGSVRKTRKNKQKTPGNGDGGSTSEAPQPPRKKRARADPTVESEEAFKNRMEVKVKIPEELKPWLVEDWDLVTRQKQLFQLPAKKNVDAILEEYANCKKSQGNVDNKEYAVNEVVAGIKEYFNVMLGTQLLYKFERPQYAEILLAHPDAPMSQVYGAPHLLRLFVRIGAMLAYTPLDEKSLALLLGYLHDFLKYLAKNSASLFTASDYKVASAEYHRKAL
uniprot
proteins
function
FUNCTION: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also a component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones.
uniprot
proteins
mass_dalton
32308
uniprot
proteins
mutagenesis
MUTAGEN 132..136; /note="Missing: Abrogates both transcriptional activation and repression by MORF4L2."; /evidence="ECO:0000269|PubMed:14506250"; MUTAGEN 263; /note="L->A: Abrogates both transcriptional activation and repression by MORF4L2."; /evidence="ECO:0000269|PubMed:14506250
uniprot
proteins
pubmed
12391155
uniprot
proteins
pubmed
12963728
uniprot
proteins
pubmed
14506250
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
7584026
uniprot
proteins
pubmed
9891081
uniprot
proteins
sequence_length
288
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins