Mapk10
entrez
26414
canonical
uniprot
Q61831
canonical
ensembl
ENSMUSG00000046709
resolver
ensp
ENSMUSP00000084065
resolver
ensp
ENSMUSP00000108467
resolver
ensp
ENSMUSP00000108468
resolver
ensp
ENSMUSP00000108469
resolver
ensp
ENSMUSP00000127193
resolver
ensp
ENSMUSP00000143448
resolver
ensp
ENSMUSP00000158744
resolver
ensp
ENSMUSP00000159947
resolver
ensp
ENSMUSP00000298754
resolver
ensp
ENSMUSP00000298762
resolver
ensp
ENSMUSP00000298764
resolver
ensp
ENSMUSP00000298778
resolver
enst
ENSMUST00000086854
resolver
enst
ENSMUST00000112846
resolver
enst
ENSMUST00000112847
resolver
enst
ENSMUST00000112848
resolver
enst
ENSMUST00000128869
resolver
enst
ENSMUST00000170792
resolver
enst
ENSMUST00000238446
resolver
enst
ENSMUST00000249849
resolver
genesymbol
Mapk10
resolver
genesymbol_syn
JNK3A1
resolver
genesymbol_syn
JNK3A2
resolver
genesymbol_syn
JNK3B1
resolver
genesymbol_syn
JNK3B2
resolver
genesymbol_syn
Jnk3
resolver
genesymbol_syn
Prkm10
resolver
genesymbol_syn
Serk2
resolver
uniprot
A0A0G2JG69
resolver
uniprot
A0A5F8MP75
resolver
uniprot
A0AB53DIG1
resolver
uniprot
E9QN59
resolver
uniprot
F6QVV4
resolver
uniprot
F7BXJ2
resolver
uniprot
F7BXK1
resolver
uniprot
Q3TQZ7
resolver
uniprot
Q78GB8
resolver
uniprot
Q80W80
resolver
uniprot
Q80W81
resolver
uniprot
Q80W82
resolver
uniprot
Q8C9D4
resolver
uniprot
Q9R0U6
resolver
uniprot_entry
A0A0G2JG69_MOUSE
resolver
uniprot_entry
A0A5F8MP75_MOUSE
resolver
uniprot_entry
A0AB53DIG1_MOUSE
resolver
uniprot_entry
E9QN59_MOUSE
resolver
uniprot_entry
F6QVV4_MOUSE
resolver
uniprot_entry
F7BXJ2_MOUSE
resolver
uniprot_entry
F7BXK1_MOUSE
resolver
uniprot_entry
MK10_MOUSE
resolver
uniprot_entry
Q3TQZ7_MOUSE
resolver
uniprot_entry
Q78GB8_MOUSE
resolver
uniprot_entry
Q80W80_MOUSE
resolver
uniprot_entry
Q80W81_MOUSE
resolver
uniprot_entry
Q80W82_MOUSE
resolver
uniprot_entry
Q8C9D4_MOUSE
resolver
uniprot_sec
Q9R0U6
resolver
activity_regulation
ACTIVITY REGULATION: Activated by threonine and tyrosine phosphorylation by two dual specificity kinases, MAP2K4 and MAP2K7. MAP2K7 phosphorylates MAPK10 on Thr-221 causing a conformational change and a large increase in Vmax for the enzyme. MAP2K4 then phosphorylates Tyr-223 resulting in a further increase in Vmax. Inhibited by dual specificity phosphatases, such as DUSP1 (By similarity). Inhibited by HDAC9. {ECO:0000250, ECO:0000269|PubMed:16611996}.
uniprot
proteins
amino_acid_sequence
MSLHFLYYCSEPTLDVKIAFCQGFDKHVDVSSIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRSYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPVKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKSQPSPSGAAVNSSESLPPSSAVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
uniprot
proteins
ec_number
2.7.11.24
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Also participates in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (By similarity). {ECO:0000250|UniProtKB:P53779, ECO:0000269|PubMed:20418776, ECO:0000269|PubMed:21554942, ECO:0000269|PubMed:22441692, ECO:0000269|PubMed:9349820}.
uniprot
proteins
mass_dalton
52532
uniprot
proteins
post_translational_modification
PTM: Dually phosphorylated on Thr-221 and Tyr-223 by MAP2K4 and MAP2K7, which activates the enzyme. MAP2K7 shows a strong preference for Thr-221 while MAP2K4 phosphorylates Tyr-223 preferentially. Weakly autophosphorylated on threonine and tyrosine residues in vitro (By similarity). {ECO:0000250}.; PTM: Palmitoylation regulates subcellular location and axonal development. {ECO:0000250}.
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
MAP kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10471813
uniprot
proteins
pubmed
10523642
uniprot
proteins
pubmed
16611996
uniprot
proteins
pubmed
17724133
uniprot
proteins
pubmed
20418776
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21554942
uniprot
proteins
pubmed
22441692
uniprot
proteins
pubmed
8717339
uniprot
proteins
pubmed
9349820
uniprot
proteins
sequence_length
464
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17724133}. Membrane {ECO:0000269|PubMed:17724133}; Lipid-anchor {ECO:0000269|PubMed:17724133}. Nucleus {ECO:0000269|PubMed:17724133}. Mitochondrion {ECO:0000269|PubMed:17724133}. Note=Palmitoylation regulates MAPK10 trafficking to cytoskeleton (By similarity). Recruited to the mitochondria in the presence of SARM1. {ECO:0000250}.
uniprot
proteins