NPY1R
entrez
4886
canonical
uniprot
P25929
canonical
ensembl
ENSG00000164128
resolver
ensp
ENSP00000354652
resolver
ensp
ENSP00000545602
resolver
ensp
ENSP00000545603
resolver
ensp
ENSP00000586283
resolver
ensp
ENSP00000586284
resolver
ensp
ENSP00000586285
resolver
ensp
ENSP00000637899
resolver
ensp
ENSP00000637900
resolver
enst
ENST00000296533
resolver
enst
ENST00000875543
resolver
enst
ENST00000875544
resolver
enst
ENST00000916224
resolver
enst
ENST00000916225
resolver
enst
ENST00000916226
resolver
enst
ENST00000967840
resolver
enst
ENST00000967841
resolver
genesymbol
NPY1R
resolver
genesymbol_syn
NPYR
resolver
genesymbol_syn
NPYY1
resolver
hgnc
HGNC:7956
resolver
uniprot
B2R6H5
resolver
uniprot_entry
NPY1R_HUMAN
resolver
uniprot_sec
B2R6H5
resolver
amino_acid_sequence
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
uniprot
proteins
function
FUNCTION: Receptor for neuropeptide Y (NPY) and peptide YY (PYY) (PubMed:1317848, PubMed:1321422, PubMed:35165283, PubMed:35507650, PubMed:38882210). Can also bind with high affinity [Leu-31, Pro-34]NPY, an analog of NPY modified at residues 31 and 34 of the mature form, while having virtually no affinity for pancreatic polypeptide (PP/PPY) at physiological concentrations (PubMed:1321422, PubMed:38882210). NPY or PYY binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production (PubMed:1317848, PubMed:1321422, PubMed:35507650, PubMed:38882210). Receptor activation by ligands also leads to an increase of intracellular Ca(2+) levels (PubMed:1317848, PubMed:1321422, PubMed:35165283). As a receptor for NPY, it is involved in the regulation of eating behavior and NPY-induced stimulation of food intake (By similarity). Involved in the regulation of colonic antisecretory tone, and colonic contractility (By similarity). {ECO:0000250|UniProtKB:Q04573, ECO:0000250|UniProtKB:Q9WVD0, ECO:0000269|PubMed:1317848, ECO:0000269|PubMed:1321422, ECO:0000269|PubMed:35165283, ECO:0000269|PubMed:35507650, ECO:0000269|PubMed:38882210}.
uniprot
proteins
mass_dalton
44392
uniprot
proteins
mutagenesis
MUTAGEN 1..30; /note="Missing: Decreased neuropeptide Y receptor activity. No effect on localization to the cell membrane."; /evidence="ECO:0000269|PubMed:35165283"; MUTAGEN 1..25; /note="Missing: No effect on neuropeptide Y receptor activity. No effect on localization to the cell membrane."; /evidence="ECO:0000269|PubMed:35165283"; MUTAGEN 26; /note="L->A: Decreased neuropeptide Y receptor activity; when associated in cis with A-28. No effect on localization to the cell membrane; when associated in cis with A-28."; /evidence="ECO:0000269|PubMed:35165283"; MUTAGEN 28; /note="F->A: Decreased neuropeptide Y receptor activity; when associated in cis with A-26. No effect on localization to the cell membrane; when associated in cis with A-26."; /evidence="ECO:0000269|PubMed:35165283"; MUTAGEN 97; /note="T->A: Slightly decreased neuropeptide Y receptor activity. No effect on localization to the cell membrane."; /evidence="ECO:0000269|PubMed:35507650"; MUTAGEN 100; /note="Y->A: Decreased neuropeptide Y receptor activity. No effect on localization to the cell membrane."; /evidence="ECO:0000269|PubMed:35507650"; MUTAGEN 104; /note="D->A: Slightly decreased neuropeptide Y receptor activity. No effect on localization to the cell membrane."; /evidence="ECO:0000269|PubMed:35507650"; MUTAGEN 120; /note="Q->A: Slightly decreased neuropeptide Y receptor activity. Deceased interaction with GNAI1. No effect on localization to the cell membrane."; /evidence="ECO:0000269|PubMed:35165283, ECO:0000269|PubMed:35507650"; MUTAGEN 121; /note="C->W: Severely decreased neuropeptide Y receptor activity. No effect on localization to the cell membrane."; /evidence="ECO:0000269|PubMed:35507650"; MUTAGEN 124; /note="I->W: Severely decreased neuropeptide Y receptor activity. No effect on localization to the cell membrane."; /evidence="ECO:0000269|PubMed:35507650"; MUTAGEN 184; /note="F->A: Decreased neuropeptide Y receptor activity. No effect on localization to the cell membrane."; /evidence="ECO:0000269|PubMed:35165283, ECO:0000269|PubMed:35507650"; MUTAGEN 200; /note="D->A: Slightly decreased neuropeptide Y receptor activity. No effect on localization to the cell membrane."; /evidence="ECO:0000269|PubMed:35507650"; MUTAGEN 205; /note="D->A: No effect on neuropeptide Y receptor activity. No effect on localization to the cell membrane."; /evidence="ECO:0000269|PubMed:35507650"; MUTAGEN 208; /note="R->A: No effect on neuropeptide Y receptor activity. No effect on localization to the cell membrane."; /evidence="ECO:0000269|PubMed:35165283, ECO:0000269|PubMed:35507650"; MUTAGEN 219; /note="Q->A: Decreased neuropeptide Y receptor activity. No effect on localization to the cell membrane."; /evidence="ECO:0000269|PubMed:35165283, ECO:0000269|PubMed:35507650"; MUTAGEN 283; /note="N->A: Severely decreased neuropeptide Y receptor activity. Severely decreased interaction with GNAI1. No effect on localization to the cell membrane."; /evidence="ECO:0000269|PubMed:35165283, ECO:0000269|PubMed:35507650"; MUTAGEN 286; /note="F->A,V: Decreased neuropeptide Y receptor activity. No effect on localization to the cell membrane."; /evidence="ECO:0000269|PubMed:35165283, ECO:0000269|PubMed:35507650"; MUTAGEN 298; /note="H->A: Decreased neuropeptide Y receptor activity. No effect on localization to the cell membrane."; /evidence="ECO:0000269|PubMed:35507650"; MUTAGEN 299; /note="N->A: Decreased neuropeptide Y receptor activity. No effect on localization to the cell membrane."; /evidence="ECO:0000269|PubMed:35507650
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
1317848
uniprot
proteins
pubmed
1321422
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
35165283
uniprot
proteins
pubmed
35217654
uniprot
proteins
pubmed
35507650
uniprot
proteins
pubmed
38882210
uniprot
proteins
pubmed
8095935
uniprot
proteins
sequence_length
384
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:35165283, ECO:0000269|PubMed:35507650}; Multi-pass membrane protein {ECO:0000269|PubMed:35165283, ECO:0000269|PubMed:35507650}.
uniprot
proteins
transmembrane_region
TRANSMEM 38..63; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:35507650, ECO:0007744|PDB:7X9A"; TRANSMEM 77..99; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:35507650, ECO:0007744|PDB:7X9A"; TRANSMEM 111..136; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:35507650, ECO:0007744|PDB:7X9A"; TRANSMEM 155..175; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:35507650, ECO:0007744|PDB:7X9A"; TRANSMEM 209..233; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:35507650, ECO:0007744|PDB:7X9A"; TRANSMEM 263..285; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:35507650, ECO:0007744|PDB:7X9A"; TRANSMEM 300..323; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:35507650, ECO:0007744|PDB:7X9A
uniprot
proteins