P86172
uniprot
P86172
canonical
amino_acid_sequence
KLVVVFGATGAQGGSVARTLLEDGTFRVRVVTRNPEQKLLADLAKRLGLHYVVYSGLENIKKLAAGHFDGKGEVEEYFRKPEEYIGQNVGLSTCRTTPEEYEKLGFQGAQDLANMFRFYALKPDRNIDLTLRAQTLDQWLEQHKGDFAHL
uniprot
proteins
function
FUNCTION: Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsequently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
16901
uniprot
proteins
protein_family
NmrA-type oxidoreductase family
uniprot
proteins
sequence_length
150
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Under normal redox growth conditions localizes in the cytoplasm and perinuclear region. Nuclear localization is promoted by increased intracellular nitric oxide and reduced NADPH/NADP(+) ratios (By similarity). {ECO:0000250}.
uniprot
proteins