HS3ST1
entrez
9957
canonical
uniprot
O14792
canonical
ensembl
ENSG00000002587
resolver
ensp
ENSP00000002596
resolver
ensp
ENSP00000622121
resolver
ensp
ENSP00000622122
resolver
ensp
ENSP00000622123
resolver
ensp
ENSP00000622124
resolver
enst
ENST00000002596
resolver
enst
ENST00000952062
resolver
enst
ENST00000952063
resolver
enst
ENST00000952064
resolver
enst
ENST00000952065
resolver
genesymbol
HS3ST1
resolver
genesymbol_syn
3OST
resolver
genesymbol_syn
3OST1
resolver
hgnc
HGNC:5194
resolver
uniprot
B3KUA6
resolver
uniprot
Q6PEY8
resolver
uniprot_entry
HS3S1_HUMAN
resolver
uniprot_sec
B3KUA6
resolver
uniprot_sec
Q6PEY8
resolver
amino_acid_sequence
MAALLLGAVLLVAQPQLVPSRPAELGQQELLRKAGTLQDDVRDGVAPNGSAQQLPQTIIIGVRKGGTRALLEMLSLHPDVAAAENEVHFFDWEEHYSHGLGWYLSQMPFSWPHQLTVEKTPAYFTSPKVPERVYSMNPSIRLLLILRDPSERVLSDYTQVFYNHMQKHKPYPSIEEFLVRDGRLNVDYKALNRSLYHVHMQNWLRFFPLRHIHIVDGDRLIRDPFPEIQKVERFLKLSPQINASNFYFNKTKGFYCLRDSGRDRCLHESKGRAHPQVDPKLLNKLHEYFHEPNKKFFELVGRTFDWH
uniprot
proteins
ec_number
2.8.2.23
uniprot
proteins
function
FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan (PubMed:8900198, PubMed:9346953, PubMed:9988768). Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact) (PubMed:8900198, PubMed:9988768). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site (PubMed:8900198, PubMed:9988768). {ECO:0000269|PubMed:8900198, ECO:0000269|PubMed:9346953, ECO:0000269|PubMed:9988768}.
uniprot
proteins
mass_dalton
35773
uniprot
proteins
protein_family
Sulfotransferase 1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8900198
uniprot
proteins
pubmed
9346953
uniprot
proteins
pubmed
9988767
uniprot
proteins
pubmed
9988768
uniprot
proteins
sequence_length
307
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus lumen {ECO:0000305}.
uniprot
proteins