Rrm2
entrez
20135
canonical
uniprot
P11157
canonical
ensembl
ENSMUSG00000020649
resolver
ensp
ENSMUSP00000020980
resolver
enst
ENSMUST00000020980
resolver
genesymbol
Rrm2
resolver
uniprot
Q3UI23
resolver
uniprot
Q542E2
resolver
uniprot_entry
RIR2_MOUSE
resolver
uniprot_sec
Q3UI23
resolver
uniprot_sec
Q542E2
resolver
amino_acid_sequence
MLSVRTPLATIADQQQLQLSPLKRLTLADKENTPPTLSSTRVLASKAARRIFQDSAELESKAPTNPSVEDEPLLRENPRRFVVFPIEYHDIWQMYKKAEASFWTAEEVDLSKDIQHWEALKPDERHFISHVLAFFAASDGIVNENLVERFSQEVQVTEARCFYGFQIAMENIHSEMYSLLIDTYIKDPKEREYLFNAIETMPCVKKKADWALRWIGDKEATYGERVVAFAAVEGIFFSGSFASIFWLKKRGLMPGLTFSNELISRDEGLHCDFACLMFKHLVHKPAEQRVREIITNAVRIEQEFLTEALPVKLIGMNCTLMKQYIEFVADRLMLELGFNKIFRVENPFDFMENISLEGKTNFFEKRVGEYQRMGVMSNSTENSFTLDADF
uniprot
proteins
ec_number
1.17.4.1
uniprot
proteins
function
FUNCTION: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
45096
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Ser-20 relieves the inhibitory effect on Wnt signaling (By similarity). Phosphorylated on Thr-33 by CDK1 and CDK2; predominantly in G2 and M phase (By similarity). {ECO:0000250|UniProtKB:P31350}.; PTM: Ubiquitinated by the SCF(CCNF) E3 ubiquitin-protein ligase complex; leading to its degradation by the proteasome. {ECO:0000250|UniProtKB:P31350}.
uniprot
proteins
protein_family
Ribonucleoside diphosphate reductase small chain family
uniprot
proteins
pubmed
12087093
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2684652
uniprot
proteins
pubmed
3025593
uniprot
proteins
pubmed
7583667
uniprot
proteins
pubmed
8876648
uniprot
proteins
sequence_length
390
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P31350}. Nucleus {ECO:0000250|UniProtKB:P31350}. Note=Localized to the cytoplasm in S phase cells. May localize to the nucleus in G2 phase cells. {ECO:0000250|UniProtKB:P31350}.
uniprot
proteins