Eif4ebp1
entrez
13685
canonical
uniprot
Q60876
canonical
ensembl
ENSMUSG00000031490
resolver
ensp
ENSMUSP00000033880
resolver
enst
ENSMUST00000033880
resolver
genesymbol
Eif4ebp1
resolver
uniprot
Q3TDS8
resolver
uniprot
Q9CZ40
resolver
uniprot_entry
4EBP1_MOUSE
resolver
uniprot_sec
Q3TDS8
resolver
uniprot_sec
Q9CZ40
resolver
amino_acid_sequence
MSAGSSCSQTPSRAIPTRRVALGDGVQLPPGDYSTTPGGTLFSTTPGGTRIIYDRKFLMECRNSPVAKTPPKDLPAIPGVTSPTSDEPPMQASQSQLPSSPEDKRAGGEESQFEMDI
uniprot
proteins
function
FUNCTION: Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (PubMed:7629182). {ECO:0000250|UniProtKB:Q13541, ECO:0000269|PubMed:7629182}.
uniprot
proteins
mass_dalton
12325
uniprot
proteins
mutagenesis
MUTAGEN 113; /note="F->A: Impaired interaction with RPTOR."; /evidence="ECO:0000269|PubMed:24139800
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine and threonine residues in response to insulin, EGF and PDGF. Phosphorylation at Thr-36, Thr-45, Ser-64 and Thr-69, corresponding to the hyperphosphorylated form, is regulated by mTORC1 and abolishes binding to EIF4E. {ECO:0000269|PubMed:18515545, ECO:0000269|PubMed:7629182}.; PTM: Ubiquitinated: when eIF4E levels are low, hypophosphorylated form is ubiquitinated by the BCR(KLHL25) complex, leading to its degradation and serving as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. Not ubiquitinated when hyperphosphorylated (at Thr-36, Thr-45, Ser-64 and Thr-69) or associated with eIF4E. {ECO:0000250|UniProtKB:Q13541}.
uniprot
proteins
protein_family
EIF4E-binding protein family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17273556
uniprot
proteins
pubmed
18515545
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19175792
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24139800
uniprot
proteins
pubmed
26359501
uniprot
proteins
pubmed
7629182
uniprot
proteins
sequence_length
117
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18515545}. Nucleus {ECO:0000269|PubMed:18515545}. Note=Localization to the nucleus is unaffected by phosphorylation status. {ECO:0000269|PubMed:18515545}.
uniprot
proteins