Ascl2
entrez
17173
canonical
uniprot
O35885
canonical
ensembl
ENSMUSG00000009248
resolver
ensp
ENSMUSP00000009392
resolver
enst
ENSMUST00000009392
resolver
genesymbol
Ascl2
resolver
genesymbol_syn
Mash2
resolver
uniprot
Q3TJR9
resolver
uniprot
Q9WUJ7
resolver
uniprot_entry
ASCL2_MOUSE
resolver
uniprot_entry
Q3TJR9_MOUSE
resolver
uniprot_sec
Q9WUJ7
resolver
amino_acid_sequence
MEAHLDWYGVPGLQEASDACPRESCSSALPEAREGANVHFPPHPVPREHFSCAAPELVAGAQGLNASLMDGGALPRLMPTSSGVAGACAARRRQASPELLRCSRRRRSGATEASSSSAAVARRNERERNRVKLVNLGFQALRQHVPHGGANKKLSKVETLRSAVEYIRALQRLLAEHDAVRAALAGGLLTPATPPSDECAQPSASPASASLSCASTSPSPDRLGCSEPTSPRSAYSSEESSCEGELSPMEQELLDFSSWLGGY
uniprot
proteins
function
FUNCTION: Transcription factor (PubMed:10611232, PubMed:29500235). Binds to E-box motifs 5'-CANNTG-3' in the regulatory elements of target genes, probably as a heterodimer with another basic helix-loop-helix (bHLH) protein such as the transcription factor TCF3 (PubMed:10611232, PubMed:29500235). May bind both open and closed chromatin, acting as a pioneer transcription factor to allow other factors to bind and activate lineage-specific genes (PubMed:29500235). Required during post-implantation development for the generation of some differentiated trophoblast cell types (PubMed:8090202). Transcriptional activity of ASCL2 may be antagonised in a subset of trophoblast cells by bHLH transcription factor HAND1, perhaps by competing for dimerization with other bHLH proteins (PubMed:10611232). Involved in differentiation and function of follicular T-helper (Tfh) cells, thereby playing a role in germinal center responses; probably modulates expression of genes involved in Tfh cell function, such as BCL6 (PubMed:24463518). May also act as a suppressor of Th1-, Th2- and Th17-cell differentiation (PubMed:24463518). Induces the formation of stem cells in intestinal crypts in vitro, synergistically activating transcription of target genes, such as SOX9, together with TCF4/beta-catenin (PubMed:25620640). May form a bistable transcriptional switch, controlling expression of its own gene together with Wnt/R-spondin signaling, and thereby maintaining stem cell characteristics (PubMed:25620640). Modulates expression of target genes, including perhaps down-regulating EGR1/Krox24 and chemokine CXCL10/Mob-1 and up-regulating CXCR4 and CDKN1C/p57kip2, in Schwann cells (By similarity). May play a role in reducing proliferation of Schwann cells, perhaps acting via modulation of expression of CDKN1C (By similarity). May be dispensable for blastocyst formation and later embryonic function (PubMed:8090202, PubMed:9622625). May be involved in the determination of neuronal precursors (By similarity). {ECO:0000250|UniProtKB:P19360, ECO:0000269|PubMed:10611232, ECO:0000269|PubMed:24463518, ECO:0000269|PubMed:25620640, ECO:0000269|PubMed:29500235, ECO:0000269|PubMed:8090202, ECO:0000269|PubMed:9622625}.
uniprot
proteins
mass_dalton
27784
uniprot
proteins
pubmed
10495277
uniprot
proteins
pubmed
10611232
uniprot
proteins
pubmed
10915772
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24463518
uniprot
proteins
pubmed
25620640
uniprot
proteins
pubmed
29500235
uniprot
proteins
pubmed
7773285
uniprot
proteins
pubmed
8090202
uniprot
proteins
pubmed
9175731
uniprot
proteins
pubmed
9622625
uniprot
proteins
sequence_length
263
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P19360}.
uniprot
proteins