Cmtm4
entrez
97487
canonical
uniprot
Q8CJ61
canonical
ensembl
ENSMUSG00000096188
resolver
ensp
ENSMUSP00000137332
resolver
enst
ENSMUST00000179802
resolver
genesymbol
Cmtm4
resolver
genesymbol_syn
Cklfsf4
resolver
uniprot
Q8K143
resolver
uniprot_entry
CKLF4_MOUSE
resolver
uniprot_sec
Q8K143
resolver
amino_acid_sequence
MRGGEELDGFEGEASSTSMISGASSPYQPTTEPVSQRRGLAGLRCDPDYLRGALGRLKVAQVILALIAFICIETIMECSPCEGLYFFEFVSCSAFVVTGVLLILFSLNLHMRIPQINWNLTDLVNTGLSTFFFFIASIVLAALNHKTGAEIAAVIFGFLATAAYAVSTFLAMQKWRVSVRQQSTNDYIRARTESRDVDSRPEIQRLDT
uniprot
proteins
function
FUNCTION: Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation. {ECO:0000250|UniProtKB:Q8IZR5}.
uniprot
proteins
mass_dalton
22921
uniprot
proteins
protein_family
Chemokine-like factor family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
208
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 59..79; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 85..105; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 123..143; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 151..171; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins