Dmbt1
entrez
170568
canonical
uniprot
Q8CIZ5
canonical
ensembl
ENSRNOG00000090509
resolver
ensp
ENSRNOP00000076172
resolver
enst
ENSRNOT00000093289
resolver
genesymbol
Dmbt1
resolver
uniprot
A0A1W2Q688
resolver
uniprot
Q62827
resolver
uniprot
Q6QD54
resolver
uniprot_entry
A0A1W2Q688_RAT
resolver
uniprot_entry
DMBT1_RAT
resolver
uniprot_sec
Q62827
resolver
uniprot_sec
Q6QD54
resolver
amino_acid_sequence
MGISIVIFEICLLWGQILSTASQSRSSTPDWWNHGGTINDVIYDTQETPEVTTTQVPDSTSIGTDSGLAVRLVNGGDRCRGRVEILYQGSWGTMCDDGTDSGLAVRLVNGGDRCRGRVEILYQGSWGTMCDDSWDINDANVVCRQLGCGWALSAPGSAQFGQGLGPIVLDDVACRGHEAYLWSCSHRGWLSHNCGHQEDAGVICSDSQTSSPTPGWWNPGGTNNDVIYDTQETTETSQTSSPTPDWWNHGGTINDVIYDTQETTEGTDSGLAVRLVNGGDRCRGRVEILYQGSWGTVCDDSWDINDANVVCRQLGCGWALSAPGSAQFGQGSGSIVLDDVACRGHEAYLWSCSHRGWLSHNCGHQEDAGVICSYSQTSSPTPDSQTSSPTPGWWNPGGTNNDVSYGPEQTTDATDSGLAVRLVNGGDRCQGRVEILYQGSWGTVCDDSWDTKDANVVCRQLVCGWALSAPGSAHFGQGSGSIVLDDVACTGHEAYLWSCSHRGWLSHNCGHHEDAGVICSDAQTQSTTWPDMWPTTTPETTTDWWTTKYSSSVPTTQFPTIADWWTTPSPEYTCGGLLTLPYGQFSSPYYPGSYPNNARCLWKIFVSSMNRVTVVFTDVQLEGGCNYDYILVFDGPENNSSLIARVCDGFNGSFTSTQNFMSVVFITDGSVTRRGFQADYYSTPISTSTTSPTTFPIVTDWWTTPSPEYTCGGLLTLPYGQFSSPYYPGSYPNNARCLWKIFVPSMNRVTVVFTDVQLEGGCNYDYILGFDGPEYNSSLIARVCDGSNGSFTSTQNFMSVVFITDGSVTRRGFQADYYSTPIRTSTTPPTTFPIITGNDSSLVLRLVNGTNRCEGRVEILYRGSWVPCADDSWDINDANVVCRQLGCGSALSAPGNAWFGQGSGLIVLDDVSCSGYESHLWNCRHPGWLVHNCRHVEDAGVICSLPDPTPSPGPVWTSPPFVNYTCGGFLTGLSGQFSSPYYPGSYPNNARCLWNIEVPNNYRVTVVFRDVQLEGGCNYDYIEIFDGPHHSSPLIARVCDGAMGSFTSTSNFMSVRFTTDHSVTRRGFRADYYSDFDNNTTNLLCLSNHMRASVSRSYLQSMGYSSRDLVIPGWNVSYQCQPQITQREVIFTIPYTGCGTTKQADNETINYSNFLKAAVSNGIIKRRKDLHIHVSCKMLQNTWVNTMYITNNTVEIQEVQYGNFDVNISFYTSSSFLYPVTSSPYYVDLDQNLYLQAEVLHSDTSLALFVDTCVASPHPNDFSSLTYDLIRSGCIRDETYQSYSSPSPRITRFKFSSFHFLNRFPSVYLQCKLVVCRANDVSSRCYRGCVVRSKRDVGSYQEKVDVVLGPIQLQSPSKEKRSLDLAVADVEKPASSQEVYPTAAIFGGVFLALVVAVAAFTLGRKTRTARGQPPSTKM
uniprot
proteins
function
FUNCTION: May play roles in mucosal defense system, cellular immune defense and epithelial differentiation (By similarity). May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. May function as a binding protein in saliva for the regulation of taste sensation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophages tissues throughout the body, including epithelial cells lining the gastrointestinal tract (By similarity). Required for terminal differentiation of columnar epithelial cells during early embryogenesis. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell (By similarity). {ECO:0000250, ECO:0000269|PubMed:11121438, ECO:0000269|PubMed:12368192, ECO:0000269|PubMed:7629065}.
uniprot
proteins
mass_dalton
155720
uniprot
proteins
post_translational_modification
PTM: Highly N- and O-glycosylated. The O-glycans are heavily sulfated (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
DMBT1 family
uniprot
proteins
pubmed
11121438
uniprot
proteins
pubmed
12368192
uniprot
proteins
pubmed
7629065
uniprot
proteins
sequence_length
1418
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7629065}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Lumenal side {ECO:0000250}. Note=Localized to the lumenal aspect of crypt cells in the small intestine. In the colon, seen in the lumenal aspect of surface epithelial cells (By similarity). Formed in the ducts of von Ebner gland and released into the fluid bathing the taste buds contained in the taste papillae. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 1383..1403; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins