CACTIN
entrez
58509
canonical
uniprot
Q8WUQ7
canonical
ensembl
ENSG00000105298
resolver
ensp
ENSP00000248420
resolver
ensp
ENSP00000415078
resolver
ensp
ENSP00000703104
resolver
ensp
ENSP00000734393
resolver
genesymbol
CACTIN
resolver
genesymbol_syn
C19orf29
resolver
hgnc
HGNC:29938
resolver
uniprot
A6NNA9
resolver
uniprot
A9UL12
resolver
uniprot
O75229
resolver
uniprot
Q7LE08
resolver
uniprot
Q9BTA6
resolver
uniprot
Q9Y5A4
resolver
uniprot_entry
CATIN_HUMAN
resolver
uniprot_sec
A6NNA9
resolver
uniprot_sec
A9UL12
resolver
uniprot_sec
O75229
resolver
uniprot_sec
Q7LE08
resolver
uniprot_sec
Q9BTA6
resolver
uniprot_sec
Q9Y5A4
resolver
amino_acid_sequence
MGRDTRSRSRSAGRRGRRRQSQSGSRSRSRSHGRRNRRRREDEGRRRRRRRSRERRSDSEEERWQRSGMRSRSPPRPKWHSRDGSSQSDSGEEQSRGQWARRRRRARSWSPSSSASSSASPGRSQSPRAAAAALSQQQSLQERLRLREERKQQEELMKAFETPEEKRARRLAKKEAKERKKREKMGWGEEYMGYTNTDNPFGDNNLLGTFIWNKALEKKGISHLEEKELKERNKRIQEDNRLELQKVKQLRLEREREKAMREQELEMLQREKEAEHFKTWEEQEDNFHLQQAKLRSKIRIRDGRAKPIDLLAKYISAEDDDLAVEMHEPYTFLNGLTVADMEDLLEDIQVYMELEQGKNADFWRDMTTITEDEISKLRKLEASGKGPGERREGVNASVSSDVQSVFKGKTYNQLQVIFQGIEGKIRAGGPNLDMGYWESLLQQLRAHMARARLRERHQDVLRQKLYKLKQEQGVESEPLFPILKQEPQSPSRSLEPEDAAPTPPGPSSEGGPAEAEVDGATPTEGDGDGDGEGEGEGEAVLMEEDLIQQSLDDYDAGRYSPRLLTAHELPLDAHVLEPDEDLQRLQLSRQQLQVTGDASESAEDIFFRRAKEGMGQDEAQFSVEMPLTGKAYLWADKYRPRKPRFFNRVHTGFEWNKYNQTHYDFDNPPPKIVQGYKFNIFYPDLIDKRSTPEYFLEACADNKDFAILRFHAGPPYEDIAFKIVNREWEYSHRHGFRCQFANGIFQLWFHFKRYRYRR
uniprot
proteins
function
FUNCTION: Plays a role in pre-mRNA splicing by facilitating excision of a subset of introns (PubMed:28062851). Required for the splicing of CDCA5/Sororin, a regulator of sister chromatid cohesion (PubMed:28062851). Involved in the regulation of innate immune response (PubMed:20829348). Acts as a negative regulator of Toll-like receptor, interferon-regulatory factor (IRF) and canonical NF-kappa-B signaling pathways (PubMed:20829348, PubMed:26363554). Contributes to the regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous pro-inflammatory stimuli (PubMed:20829348, PubMed:26363554). {ECO:0000269|PubMed:20829348, ECO:0000269|PubMed:26363554, ECO:0000269|PubMed:28062851}.
uniprot
proteins
mass_dalton
88702
uniprot
proteins
protein_family
CACTIN family
uniprot
proteins
pubmed
10508479
uniprot
proteins
pubmed
11991638
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20829348
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26363554
uniprot
proteins
pubmed
28062851
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
34365507
uniprot
proteins
sequence_length
758
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20829348, ECO:0000269|PubMed:26363554, ECO:0000269|PubMed:28062851}. Cytoplasm, cytosol {ECO:0000269|PubMed:26363554}. Note=Nuclear localization with a speckled expression pattern in some cells. Colocalizes with NFKBIL1 in the nucleus. {ECO:0000269|PubMed:20829348}.
uniprot
proteins