Ezr
entrez
54319
canonical
uniprot
P31977
canonical
ensembl
ENSRNOG00000018524
resolver
ensembl
ENSRNOG00055026243
resolver
ensembl
ENSRNOG00060009143
resolver
ensembl
ENSRNOG00065028580
resolver
ensp
ENSRNOP00000046593
resolver
ensp
ENSRNOP00055037239
resolver
ensp
ENSRNOP00060012102
resolver
ensp
ENSRNOP00065040500
resolver
enst
ENSRNOT00000046746
resolver
enst
ENSRNOT00055045441
resolver
enst
ENSRNOT00060015506
resolver
enst
ENSRNOT00065049370
resolver
genesymbol
Ezr
resolver
genesymbol_syn
Vil2
resolver
uniprot
Q5WQV4
resolver
uniprot
Q66H97
resolver
uniprot
Q8VHK3
resolver
uniprot_entry
EZRI_RAT
resolver
uniprot_sec
Q5WQV4
resolver
uniprot_sec
Q66H97
resolver
uniprot_sec
Q8VHK3
resolver
activity_regulation
ACTIVITY REGULATION: A head-to-tail association, of the N-terminal and C-terminal halves results in a closed conformation (inactive form) which is incapable of actin or membrane-binding. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWYFGLQYVDNKGFPTWLKLDKKVSAQEVRKENPVQFKFRAKFYPEDVADELIQDITQKLFFLQVKEGILSDEIYCPPETAVLLGSYAVQAKFGDYNKEMHKSGYLSSERLIPQRVMDQHKLSRDQWEDRIQVWHAEHRGMLKDSAMLEYLKIAQDLEMYGINYFEIKNKKGTDLWLGVDALGLNIYEKDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILQLCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERQQLETEKKRRETVEREKEQMLREKEELMLRLQDFEQKTKRAEKELSEQIEKALQLEEERRRAQEEAERLEADRMAALRAKEELERQAQDQIKSQEQLAAELAEYTAKIALLEEARRRKEDEVEEWQHRAKEAQDDLVKTKEELHLVMTAPPPPPPPVYEPVNYHVQEGLQDEGAEPMGYSAELSSEGILDDRNEEKRITEAEKNERVQRQLLTLSNELSQARDENKRTHNDIIHNENMRQGRDKYKTLRQIRQGNTKQRIDEFEAM
uniprot
proteins
function
FUNCTION: Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
69391
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by tyrosine-protein kinases. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding (By similarity). {ECO:0000250}.; PTM: S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex. {ECO:0000250|UniProtKB:P15311}.
uniprot
proteins
pubmed
11163215
uniprot
proteins
pubmed
11457882
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15797715
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7640303
uniprot
proteins
sequence_length
586
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:P15311}; Peripheral membrane protein {ECO:0000250|UniProtKB:P15311}; Cytoplasmic side {ECO:0000250|UniProtKB:P15311}. Cell projection {ECO:0000250|UniProtKB:P15311}. Cell projection, microvillus membrane {ECO:0000250|UniProtKB:P15311}; Peripheral membrane protein {ECO:0000250|UniProtKB:P15311}; Cytoplasmic side {ECO:0000250|UniProtKB:P15311}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:P15311}; Peripheral membrane protein {ECO:0000250|UniProtKB:P15311}; Cytoplasmic side {ECO:0000250|UniProtKB:P15311}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:P15311}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P15311}. Cell projection, microvillus {ECO:0000250|UniProtKB:P26040}. Note=Localization to the apical membrane of parietal cells depends on the interaction with PALS1. Microvillar peripheral membrane protein (cytoplasmic side) (By similarity). Localizes to cell extensions and peripheral processes of astrocytes. Colocalizes with EZR and NHERF2 at the apical cell membrane of glomerular epithelium cells. {ECO:0000250|UniProtKB:P15311, ECO:0000269|PubMed:11457882, ECO:0000269|PubMed:15797715}.
uniprot
proteins