Nanos3
entrez
244551
canonical
uniprot
P60324
canonical
ensembl
ENSMUSG00000056155
resolver
ensp
ENSMUSP00000067385
resolver
ensp
ENSMUSP00000147775
resolver
enst
ENSMUST00000070102
resolver
enst
ENSMUST00000210202
resolver
genesymbol
Nanos3
resolver
genesymbol_syn
Nos3
resolver
uniprot
A0A1B0GS32
resolver
uniprot
Q0VDU5
resolver
uniprot
Q0VDU6
resolver
uniprot_entry
A0A1B0GS32_MOUSE
resolver
uniprot_entry
NANO3_MOUSE
resolver
uniprot_entry
Q0VDU5_MOUSE
resolver
uniprot_sec
Q0VDU6
resolver
amino_acid_sequence
MGTFNLWTDYLGLARLVGALHKEEELDVRLDPKPEPKPSSESQQASKESSAAPERLCSFCKHNGESRAIYQSHVLKDEAGRVLCPILRDYVCPQCGATQEHAHTRRFCPLTSQGYTSVYCYTTRNSAGKKLTRPDKAKTQDAGHRLGGEAAAGVYAGSKSGRKPPGPSPSACCPSTTA
uniprot
proteins
function
FUNCTION: Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis. {ECO:0000269|PubMed:12947200, ECO:0000269|PubMed:17138666, ECO:0000269|PubMed:18089289, ECO:0000269|PubMed:18436203}.
uniprot
proteins
mass_dalton
19241
uniprot
proteins
protein_family
Nanos family
uniprot
proteins
pubmed
12947200
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17138666
uniprot
proteins
pubmed
18089289
uniprot
proteins
pubmed
18436203
uniprot
proteins
pubmed
19861488
uniprot
proteins
pubmed
21421998
uniprot
proteins
sequence_length
178
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19861488, ECO:0000269|PubMed:21421998}. Cytoplasm {ECO:0000269|PubMed:19861488, ECO:0000269|PubMed:21421998}. Cytoplasm, Stress granule {ECO:0000269|PubMed:19861488}. Cytoplasm, P-body {ECO:0000269|PubMed:19861488}. Note=Co-localizes with PUM2, EIF2S1 and TIAL1 in the stress granules. Co-localizes with DCP1A in the P-body. {ECO:0000269|PubMed:19861488}.
uniprot
proteins