Pum2
entrez
80913
canonical
uniprot
Q80U58
canonical
ensembl
ENSMUSG00000020594
resolver
ensp
ENSMUSP00000020915
resolver
ensp
ENSMUSP00000106751
resolver
ensp
ENSMUSP00000106752
resolver
ensp
ENSMUSP00000128292
resolver
ensp
ENSMUSP00000131074
resolver
ensp
ENSMUSP00000132122
resolver
ensp
ENSMUSP00000137020
resolver
ensp
ENSMUSP00000277319
resolver
ensp
ENSMUSP00000277320
resolver
ensp
ENSMUSP00000277323
resolver
ensp
ENSMUSP00000277331
resolver
ensp
ENSMUSP00000277333
resolver
ensp
ENSMUSP00000331821
resolver
enst
ENSMUST00000020915
resolver
enst
ENSMUST00000111122
resolver
enst
ENSMUST00000111123
resolver
genesymbol
Pum2
resolver
genesymbol_syn
Kiaa0235
resolver
uniprot
F8WH07
resolver
uniprot
F8WJ22
resolver
uniprot
Q3TQ29
resolver
uniprot
Q3UR91
resolver
uniprot
Q80UZ9
resolver
uniprot
Q91YW4
resolver
uniprot
Q925A0
resolver
uniprot
Q9ERC7
resolver
uniprot_entry
F8WH07_MOUSE
resolver
uniprot_entry
F8WJ22_MOUSE
resolver
uniprot_entry
PUM2_MOUSE
resolver
uniprot_entry
Q3TQ29_MOUSE
resolver
uniprot_entry
Q3UR91_MOUSE
resolver
uniprot_sec
Q80UZ9
resolver
uniprot_sec
Q91YW4
resolver
uniprot_sec
Q925A0
resolver
uniprot_sec
Q9ERC7
resolver
amino_acid_sequence
MNHDFQALALESRGMGELLPTKKFWEPDDSTKDGQKGIFLGDDEWRETAWGTSHHSMSQPIMVQRRSGQSFHGNSEVNAILSPRSESGGLGVSMVEYVLSSSPADKLDSRFRKGTFGTRDAETDGPEKGDQKGKASPFEEDQNRDLKQDDEDSKINGRGLPNGMDADCKDFNRTPGSRQASPTEVVERLGPSTNPPEGLGPLPNPTANKPLVEEFSNPETQNLDAMDQVGLDSLQFDYPGNQVPMDSSGATVGLFDYNSQQQLFQRTSALTVQQLTAAQQQQYALAAAQQPHIAGVFSAGLAPAAFVPNPYIISAAPPGTDPYTAAGLAAAATLAGPAVVPPQYYGVPWGVYPANLFQQQAAAAASNTANQQAASQAQPGQQQVLRPGAGQRPITPSQGQQGQQAESLAAAANPTLAFGQSLAAGMPGYQVLAPTAYYDQTGALVVGPGARTGLGAPVRLMAPTPVLISSTAAQAAAAAAAAGGTANSLTGSTNGLFRPIGTQPPQQQQQQQQPSTNLQSNSFYGSSSLTNSSQSSSLFSHGPGQPGSASLGFGSGSSLGAAIGSALSGFGSSVGSSASSSATRRESLSTSSDLYKRSSSSLAPIGQPFYNSLGFSSSPSPIGMPLPSQTPGHSLTPPPSLSSHGSSSSLHLGGLTNGSGRYISAAPGAEAKYRSASSTSSLFSSSSQLFPPSRLRYNRSDIMPSGRSRLLEDFRNNRFPNLQLRDLIGHIVEFSQDQHGSRFIQQKLERATPAERQIVFNEILQAAYQLMTDVFGNYVIQKFFEFGSLDQKLALATRIRGHVLPLALQMYGCRVIQKALESISSDQQVISEMVKELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFVLSTHPYGCRVIQRILEHCTAEQTLPILEELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVSEIRGKVLALSQHKFASNVVEKCVTHASRAERALLIDEVCCQNDGPHSALYTMMKDQYANYVVQKMIDMAEPAQRKIIMHKIRPHITTLRKYTYGKHILAKLEKYYLKNSPDLGPIGGPPNGML
uniprot
proteins
function
FUNCTION: Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation. Plays a role in cytoplasmic sensing of viral infection. Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm. May regulate DCUN1D3 mRNA levels. May support proliferation and self-renewal of stem cells. Binds specifically to miRNA MIR199A precursor, with PUM1, regulates miRNA MIR199A expression at a postranscriptional level (By similarity). {ECO:0000250|UniProtKB:Q8TB72}.
uniprot
proteins
mass_dalton
114314
uniprot
proteins
pubmed
11780640
uniprot
proteins
pubmed
12667987
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18089289
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19540345
uniprot
proteins
pubmed
19861488
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1066
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:19861488}. Cytoplasmic granule {ECO:0000269|PubMed:19861488}. Cytoplasm, perinuclear region {ECO:0000250}. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Colocalizes with NANOS1 and SNAPIN in the perinuclear region of germ cells (By similarity). Colocalizes with NANOS3 in the stress granules (PubMed:19861488). {ECO:0000250|UniProtKB:Q8TB72, ECO:0000269|PubMed:19861488}.
uniprot
proteins