TCIM
entrez
56892
canonical
uniprot
Q9NR00
canonical
ensembl
ENSG00000176907
resolver
ensp
ENSP00000319914
resolver
enst
ENST00000315792
resolver
genesymbol
TCIM
resolver
genesymbol_syn
C8orf4
resolver
genesymbol_syn
TC1
resolver
hgnc
HGNC:1357
resolver
uniprot_entry
TCIM_HUMAN
resolver
amino_acid_sequence
MKAKRSHQAVIMSTSLRVSPSIHGYHFDTASRKKAVGNIFENTDQESLERLFRNSGDKKAEERAKIIFAIDQDVEEKTRALMALKKRTKDKLFQFLKLRKYSIKVH
uniprot
proteins
function
FUNCTION: Seems to be involved in the regulation of cell growth an differentiation, may play different and opposite roles depending on the tissue or cell type. May enhance the WNT-CTNNB1 pathway by relieving antagonistic activity of CBY1 (PubMed:16424001, PubMed:16730711). Enhances the proliferation of follicular dendritic cells (PubMed:16730711). Plays a role in the mitogen-activated MAPK2/3 signaling pathway, positively regulates G1-to-S-phase transition of the cell cycle (PubMed:18959821). In endothelial cells, enhances key inflammatory mediators and inflammatory response through the modulation of NF-kappaB transcriptional regulatory activity (PubMed:19684084). Involved in the regulation of heat shock response, seems to play a positive feedback with HSF1 to modulate heat-shock downstream gene expression (PubMed:17603013). Plays a role in the regulation of hematopoiesis even if the mechanisms are unknown (By similarity). In cancers such as thyroid or lung cancer, it has been described as promoter of cell proliferation, G1-to-S-phase transition and inhibitor of apoptosis (PubMed:15087392, PubMed:24941347). However, it negatively regulates self-renewal of liver cancer cells via suppresion of NOTCH2 signaling (PubMed:25985737). {ECO:0000250|UniProtKB:Q9D915, ECO:0000269|PubMed:15087392, ECO:0000269|PubMed:16424001, ECO:0000269|PubMed:16730711, ECO:0000269|PubMed:17603013, ECO:0000269|PubMed:18959821, ECO:0000269|PubMed:19684084, ECO:0000269|PubMed:24941347, ECO:0000269|PubMed:25985737, ECO:0000305}.
uniprot
proteins
mass_dalton
12337
uniprot
proteins
mutagenesis
MUTAGEN 74; /note="V->E: No effect on interaction with CBY1."; /evidence="ECO:0000269|PubMed:16424001"; MUTAGEN 86; /note="K->Q: Abolishes interaction with CBY1. Forms irregular perinuclear cytoplasmic aggregates."; /evidence="ECO:0000269|PubMed:16424001"; MUTAGEN 88; /note="T->K: Abolishes interaction with CBY1."; /evidence="ECO:0000269|PubMed:16424001"; MUTAGEN 96; /note="L->R: No effect on interaction with CBY1. Accumulates at nucleoli periphery."; /evidence="ECO:0000269|PubMed:16424001
uniprot
proteins
pubmed
11056052
uniprot
proteins
pubmed
15087392
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
16424001
uniprot
proteins
pubmed
16730711
uniprot
proteins
pubmed
17603013
uniprot
proteins
pubmed
18959821
uniprot
proteins
pubmed
19684084
uniprot
proteins
pubmed
24941347
uniprot
proteins
pubmed
25985737
uniprot
proteins
sequence_length
106
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16424001, ECO:0000269|PubMed:25985737}. Nucleus, nucleolus {ECO:0000269|PubMed:16424001}. Nucleus speckle {ECO:0000269|PubMed:16424001}. Nucleus {ECO:0000269|PubMed:16424001}. Note=Localizes in nucleus speckles in presence of CBY1 (PubMed:16424001). Translocates to the nucleus upon cellular stress such as H(2)O(2) (PubMed:17603013). {ECO:0000269|PubMed:16424001, ECO:0000269|PubMed:17603013}.
uniprot
proteins