Ephb3
entrez
13845
canonical
uniprot
P54754
canonical
ensembl
ENSMUSG00000005958
resolver
ensp
ENSMUSP00000006112
resolver
enst
ENSMUST00000006112
resolver
genesymbol
Ephb3
resolver
genesymbol_syn
Etk2
resolver
genesymbol_syn
Mdk5
resolver
genesymbol_syn
Sek4
resolver
uniprot
Q62214
resolver
uniprot
Q91YS9
resolver
uniprot_entry
EPHB3_MOUSE
resolver
uniprot_sec
Q62214
resolver
uniprot_sec
Q91YS9
resolver
amino_acid_sequence
MAGARPPPGLLPLLAPLLLPLLLPAGCWALEETLMDTKWVTSELAWTSHPESGWEEVSGYDEAMNPIRTYQVCNVRESSQNNWLRTGFIWRREVQRVYVELKFTVRDCNSIPNIPGSCKETFNLFYYEADSDVASASSPFWMENPYVKVDTIAPDESFSRLDAGRVNTKVRSFGPLSKAGFYLAFQDQGACMSLISVRAFYKKCASTTAGFALFPETLTGAEPTSLVIAPGTCIANAVEVSVPLKLYCNGDGEWMVPVGACTCATGHEPAAKESQCRACPPGSYKAKQGEGPCLPCPPNSRTTSPAASICTCHNNFYRADSDSADSACTTVPSPPRGVISNVNETSLILEWSEPRDLGGRDDLLYNVICKKCRGSSGAGGPATCSRCDDNVEFVPRQLGLTERRVHISHLLAHTRYTFEVQAVNGVSGKSPLPPRYAAVNITTNQAAPSEVPTLHLHSSSGSSLTLSWAPPERPNGVILDYEMKYFEKSKGIASTVTSQKNSVQLDGLQPDARYVVQVRARTVAGYGQYSHPAEFETTSERGSGAQQLQEQLPLIVGSTVAGFVFMVVVVVIALVCLRKQRHGPDAEYTEKLQQYIAPGMKVYIDPFTYEDPNEAVREFAKEIDVSCVKIEEVIGAGEFGEVCRGRLKLPGRREVFVAIKTLKVGYTERQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMILTEFMENCALDSFLRLNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDPSDPTYTSSLGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVINAVEQDYRLPPPMDCPTALHQLMLDCWVRDRNLRPKFSQIVNTLDKLIRNAASLKVTASAPSGMSQPLLDRTVPDYTTFTTVGDWLDAIKMGRYKESFVGAGFASFDLVAQMTAEDLLRIGVTLAGHQKKILCSIQDMRLQMNQTLPVQV
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt. {ECO:0000269|PubMed:12408869, ECO:0000269|PubMed:14691139, ECO:0000269|PubMed:15223334, ECO:0000269|PubMed:19598115, ECO:0000269|PubMed:8947026, ECO:0000269|PubMed:9990854}.
uniprot
proteins
mass_dalton
109662
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Autophosphorylates upon ligand-binding. Autophosphorylation on Tyr-609 is required for interaction with SH2 domain-containing proteins (By similarity). {ECO:0000250}.; PTM: Ubiquitinated by RNF186, mainly through 'Lys-48' and 'Lys-63'-linked polyubiquitin chains. {ECO:0000250|UniProtKB:P54753}.
uniprot
proteins
protein_family
Ephrin receptor subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
10704386
uniprot
proteins
pubmed
12408869
uniprot
proteins
pubmed
14691139
uniprot
proteins
pubmed
15223334
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19598115
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27446912
uniprot
proteins
pubmed
7478528
uniprot
proteins
pubmed
7947319
uniprot
proteins
pubmed
8947026
uniprot
proteins
pubmed
9990854
uniprot
proteins
sequence_length
993
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14691139}; Single-pass type I membrane protein {ECO:0000269|PubMed:14691139}. Cell projection, dendrite {ECO:0000269|PubMed:14691139}.
uniprot
proteins
transmembrane_region
TRANSMEM 555..575; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins