Nradd
entrez
246143
canonical
uniprot
Q8K5A9
canonical
ensembl
ENSRNOG00000020936
resolver
ensp
ENSRNOP00000112382
resolver
genesymbol
Nradd
resolver
genesymbol_syn
Nrh2
resolver
genesymbol_syn
Plaidd
resolver
uniprot
G3V8U7
resolver
uniprot
Q8K5A8
resolver
uniprot_entry
NRADD_RAT
resolver
uniprot_sec
G3V8U7
resolver
uniprot_sec
Q8K5A8
resolver
amino_acid_sequence
MLHNVSKGVVYSDTALKGQDGDREGMWVGAGGALAPNTSSLFPPEPPGASSNIIPVYCALLATVVLGLLAYVAFKCWRSRKQRQQLAKARTVELGDPDRDQRHGDSSVFVDSPHGLEPCIPSQGPHADLGCRLYLHIPQQQQEEVQRLLILGEPAKGWQGLAGQLGYQAEAVETMACDQDPAYALLRDWAAQEGSGATLRVLEDALTAIGREDVVQVLSSPAEGCSVV
uniprot
proteins
function
FUNCTION: Modulates NTRK1 signaling. Can activate several intracellular signaling pathways, leading to activation of JUN. Promotes translocation of SORT1 to the cell membrane, and thereby hinders lysosomal degradation of SOTR1 and promotes its interaction with NGFR (By similarity). Both isoform 1 and isoform 2 promote apoptosis. {ECO:0000250, ECO:0000269|PubMed:12095158, ECO:0000269|PubMed:19407813}.
uniprot
proteins
mass_dalton
24400
uniprot
proteins
post_translational_modification
PTM: Isoform 1 is N-glycosylated. Isoform 2 is not N-glycosylated.
uniprot
proteins
pubmed
12095158
uniprot
proteins
pubmed
12728256
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
19407813
uniprot
proteins
sequence_length
228
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12095158}; Single-pass type III membrane protein {ECO:0000269|PubMed:12095158}. Nucleus {ECO:0000250}. Note=Proteolytic processing gives rise to an intracellular domain that translocates to the nucleus. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 53..73; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins