Mbd2
entrez
17191
canonical
uniprot
Q9Z2E1
canonical
ensembl
ENSMUSG00000024513
resolver
ensp
ENSMUSP00000073701
resolver
ensp
ENSMUSP00000110596
resolver
ensp
ENSMUSP00000342417
resolver
ensp
ENSMUSP00000342418
resolver
genesymbol
Mbd2
resolver
uniprot
E9QMV9
resolver
uniprot
Q811D9
resolver
uniprot
Q9Z2D9
resolver
uniprot_entry
MBD2_MOUSE
resolver
uniprot_sec
E9QMV9
resolver
uniprot_sec
Q811D9
resolver
uniprot_sec
Q9Z2D9
resolver
amino_acid_sequence
MRAHPGGGRCCPEQEEGESAAGGSGAGGDSAIEQGGQGSALAPSPVSGVRREGARGGGRGRGRWKQAARGGGVCGRGRGRGRGRGRGRGRGRGRGRPQSGGSGLGGDGGGGAGGCGGGSGGGVAPRRDPVPFPSGSSGPGPRGPRATESGKRMDCPALPPGWKKEEVIRKSGLSAGKSDVYYFSPSGKKFRSKPQLARYLGNAVDLSSFDFRTGKMMPSKLQKNKQRLRNDPLNQNKGKPDLNTTLPIRQTASIFKQPVTKFTNHPSNKVKSDPQRMNEQPRQLFWEKRLQGLSASDVTEQIIKTMELPKGLQGVGPGSNDETLLSAVASALHTSSAPITGQVSAAVEKNPAVWLNTSQPLCKAFIVTDEDIRKQEERVQQVRKKLEEALMADILSRAADTEEVDIDMDSGDEA
uniprot
proteins
function
FUNCTION: Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides (PubMed:9774669). Binds hemimethylated DNA as well (By similarity). Recruits histone deacetylases and DNA methyltransferases to chromatin (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity). Acts as transcriptional repressor and plays a role in gene silencing (By similarity). Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression (By similarity). May enhance the activation of some unmethylated cAMP-responsive promoters (By similarity). Selectively represses transcription activity of methylated rRNA promoters (PubMed:14610093). {ECO:0000250|UniProtKB:Q9UBB5, ECO:0000269|PubMed:14610093, ECO:0000269|PubMed:9774669}.
uniprot
proteins
mass_dalton
43501
uniprot
proteins
pubmed
10441743
uniprot
proteins
pubmed
14610093
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
9774669
uniprot
proteins
sequence_length
414
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UBB5}. Chromosome {ECO:0000250|UniProtKB:Q9UBB5}. Note=Nuclear, in discrete foci. Detected at replication foci in late S phase. Localizes to methylated chromatin. Localizes to sites of DNA damage in a manner partially dependent on ZMYND8. {ECO:0000250|UniProtKB:Q9UBB5}.
uniprot
proteins