RAB8B
entrez
51762
canonical
uniprot
Q92930
canonical
ensembl
ENSG00000166128
resolver
ensp
ENSP00000312734
resolver
ensp
ENSP00000654106
resolver
enst
ENST00000321437
resolver
genesymbol
RAB8B
resolver
hgnc
HGNC:30273
resolver
uniprot
Q5JPC4
resolver
uniprot
Q9P293
resolver
uniprot_entry
RAB8B_HUMAN
resolver
uniprot_sec
Q5JPC4
resolver
uniprot_sec
Q9P293
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) including RAB3IP/RABIN8 which promotes the exchange of bound GDP for free GTP (PubMed:12221131). Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs) (Probable). {ECO:0000269|PubMed:12221131, ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MAKTYDYLFKLLLIGDSGVGKTCLLFRFSEDAFNTTFISTIGIDFKIRTIELDGKKIKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIKNWIRNIEEHASSDVERMILGNKCDMNDKRQVSKERGEKLAIDYGIKFLETSAKSSANVEEAFFTLARDIMTKLNRKMNDSNSAGAGGPVKITENRSKKTSFFRCSLL
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB8B may be involved in polarized vesicular trafficking and neurotransmitter release (Probable). May participate in cell junction dynamics in Sertoli cells (By similarity). May also participate in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route (PubMed:32344433). {ECO:0000250|UniProtKB:P61006, ECO:0000250|UniProtKB:P70550, ECO:0000269|PubMed:32344433, ECO:0000305}.
uniprot
proteins
mass_dalton
23584
uniprot
proteins
mutagenesis
MUTAGEN 72; /note="T->A: Loss of phosphorylation. No effect on GDI1 and GDI2 binding. Reduced binding to CHM and CHML."; /evidence="ECO:0000269|PubMed:29125462"; MUTAGEN 72; /note="T->E: Phosphomimetic mutant. Loss of binding to GDI1, GDI2, CHM, and CHML."; /evidence="ECO:0000269|PubMed:29125462
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Thr-72 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2. {ECO:0000269|PubMed:29125462}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
12221131
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21255211
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
29125462
uniprot
proteins
pubmed
32344433
uniprot
proteins
pubmed
9030196
uniprot
proteins
sequence_length
207
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:21255211}; Lipid-anchor {ECO:0000269|PubMed:21255211}; Cytoplasmic side {ECO:0000269|PubMed:21255211}. Endosome membrane {ECO:0000269|PubMed:32344433}. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. Colocalized with MICAL1, GRAF1/ARHGAP26 and GRAF2/ARHGAP10 on endosomal tubules (PubMed:32344433). {ECO:0000269|PubMed:32344433}.
uniprot
proteins