Mc2r
entrez
17200
canonical
uniprot
Q64326
canonical
ensembl
ENSMUSG00000045569
resolver
ensp
ENSMUSP00000058691
resolver
ensp
ENSMUSP00000310248
resolver
ensp
ENSMUSP00000310254
resolver
enst
ENSMUST00000052347
resolver
genesymbol
Mc2r
resolver
genesymbol_syn
Acthr
resolver
uniprot
Q544P9
resolver
uniprot_entry
ACTHR_MOUSE
resolver
uniprot_entry
Q544P9_MOUSE
resolver
amino_acid_sequence
MKHIINSYEHTNDTARNNSDCPDVVLPEEIFFTISVIGILENLIVLLAVIKNKNLQSPMYFFICSLAISDMLGSLYKILENILIMFRNMGYLKPRGSFESTADDIIDCMFILSLLGSIFSLSVIAADRYITIFHALQYHSIVTMRRTIITLTIIWMFCTGSGITMVIFSHHIPTVLTFTSLFPLMLVFILCLYIHMFLLARSHARKISTLPRTNMKGAMTLTILLGVFIFCWAPFVLHVLLMTFCPNNPYCVCYMSLFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKRMLFCNRY
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for corticotropin/ACTH, primarily expressed in adrenal cortex where it plays a key role in the regulation of adrenocortical function (By similarity). Upon activation, couples to G(s) protein, stimulating adenylate cyclase and activating the cAMP-dependent signaling pathway, the MAPK cascade as well as the PKA pathway, leading to steroidogenic factor 1/NR5A1-mediated transcriptional activation (PubMed:17989225). Activation by ACTH facilitates the release of adrenal glucocorticoids, including cortisol and corticosterone (By similarity). In addition, MC2R is required for fetal and neonatal adrenal gland development (PubMed:16109736). {ECO:0000250|UniProtKB:Q01718, ECO:0000269|PubMed:16109736, ECO:0000269|PubMed:17989225}.
uniprot
proteins
mass_dalton
33982
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by MGRN1 that may be involved in post-endocytic trafficking and/or degradation of internalized receptor. {ECO:0000250|UniProtKB:Q01718}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
16109736
uniprot
proteins
pubmed
17989225
uniprot
proteins
pubmed
7626130
uniprot
proteins
pubmed
7875603
uniprot
proteins
sequence_length
296
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q01718}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q01718}.
uniprot
proteins
transmembrane_region
TRANSMEM 28..47; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q01718"; TRANSMEM 61..86; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q01718"; TRANSMEM 100..126; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q01718"; TRANSMEM 147..172; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q01718"; TRANSMEM 173..195; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q01718"; TRANSMEM 215..241; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q01718"; TRANSMEM 257..279; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q01718
uniprot
proteins