BMP5
entrez
653
canonical
uniprot
P22003
canonical
ensembl
ENSG00000112175
resolver
ensp
ENSP00000359866
resolver
ensp
ENSP00000571582
resolver
ensp
ENSP00000646993
resolver
ensp
ENSP00000646994
resolver
genesymbol
BMP5
resolver
hgnc
HGNC:1072
resolver
uniprot
A8K694
resolver
uniprot
B4E0Y4
resolver
uniprot
M9VUD0
resolver
uniprot
Q9H547
resolver
uniprot
Q9NTM5
resolver
uniprot_entry
A8K694_HUMAN
resolver
uniprot_entry
BMP5_HUMAN
resolver
uniprot_entry
M9VUD0_HUMAN
resolver
uniprot_sec
B4E0Y4
resolver
uniprot_sec
Q9H547
resolver
uniprot_sec
Q9NTM5
resolver
amino_acid_sequence
MHLTVFLLKGIVGFLWSCWVLVGYAKGGLGDNHVHSSFIYRRLRNHERREIQREILSILGLPHRPRPFSPGKQASSAPLFMLDLYNAMTNEENPEESEYSVRASLAEETRGARKGYPASPNGYPRRIQLSRTTPLTTQSPPLASLHDTNFLNDADMVMSFVNLVERDKDFSHQRRHYKEFRFDLTQIPHGEAVTAAEFRIYKDRSNNRFENETIKISIYQIIKEYTNRDADLFLLDTRKAQALDVGWLVFDITVTSNHWVINPQNNLGLQLCAETGDGRSINVKSAGLVGRQGPQSKQPFMVAFFKASEVLLRSVRAANKRKNQNRNKSSSHQDSSRMSSVGDYNTSEQKQACKKHELYVSFRDLGWQDWIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLMFPDHVPKPCCAPTKLNAISVLYFDDSSNVILKKYRNMVVRSCGCH
uniprot
proteins
function
FUNCTION: Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cartilage and bone formation or neurogenesis (PubMed:11580864, PubMed:29321139). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2 (PubMed:11580864). In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes (PubMed:11580864, PubMed:29321139). Can also signal through non-canonical pathway such as MAPK p38 signaling cascade to promote chondrogenic differentiation (PubMed:20402566). Promotes the expression of HAMP, this is repressed by its interaction with ERFE (PubMed:30097509). {ECO:0000269|PubMed:11580864, ECO:0000269|PubMed:20402566, ECO:0000269|PubMed:29321139, ECO:0000269|PubMed:30097509}.
uniprot
proteins
mass_dalton
51737
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
11580864
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20402566
uniprot
proteins
pubmed
2263636
uniprot
proteins
pubmed
29321139
uniprot
proteins
pubmed
30097509
uniprot
proteins
sequence_length
454
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins