Asic2
entrez
11418
canonical
uniprot
Q925H0
canonical
ensembl
ENSMUSG00000020704
resolver
ensp
ENSMUSP00000021045
resolver
ensp
ENSMUSP00000067095
resolver
genesymbol
Asic2
resolver
genesymbol_syn
Accn1
resolver
genesymbol_syn
Bnac1
resolver
uniprot
B2RRQ1
resolver
uniprot
Q3UYD3
resolver
uniprot
Q5SUU2
resolver
uniprot
Q61203
resolver
uniprot_entry
ASIC2_MOUSE
resolver
uniprot_entry
B2RRQ1_MOUSE
resolver
uniprot_entry
Q3UYD3_MOUSE
resolver
uniprot_sec
Q5SUU2
resolver
uniprot_sec
Q61203
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by the diuretic drug amiloride. {ECO:0000269|PubMed:9368048}.
uniprot
proteins
amino_acid_sequence
MDLKESPSEGSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPTVLEALRQKANFKHYKPKQFSMLEFLHRVGHDLKDMMLYCKFKGQECGHQDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEEEGSHDENMSTCDTMPNHSETISHTVNVPLQTALGTLEEIAC
uniprot
proteins
function
FUNCTION: Forms pH-gated trimeric sodium channels that act as postsynaptic excitatory sensors in the nervous system (PubMed:14960591, PubMed:9368048). Upon extracellular acidification, these channels generate rapid, transient inward currents that fully desensitize (PubMed:11306621, PubMed:14960591, PubMed:9368048). Highly selective for sodium, they are permeable to other cations (PubMed:9368048). By forming heterotrimeric channels with ASIC1, could contribute to synaptic plasticity, learning, and memory (PubMed:14960591). Additionally, as acid sensors at nerve terminals, plays a role in mechanosensation and phototransduction (PubMed:11069180, PubMed:14762118, PubMed:15537887, PubMed:20064394). {ECO:0000269|PubMed:11069180, ECO:0000269|PubMed:11306621, ECO:0000269|PubMed:14762118, ECO:0000269|PubMed:14960591, ECO:0000269|PubMed:15537887, ECO:0000269|PubMed:20064394, ECO:0000269|PubMed:9368048}.; FUNCTION: [Isoform 2]: Has no pH-gated sodium channel activity per se but can associate with other ASICs to produce functional channels with specific properties. {ECO:0000269|PubMed:9368048}.
uniprot
proteins
mass_dalton
57739
uniprot
proteins
protein_family
ASIC2 subfamily
uniprot
proteins
protein_family
Amiloride-sensitive sodium channel (TC 1.A.6) family
uniprot
proteins
pubmed
11069180
uniprot
proteins
pubmed
11306621
uniprot
proteins
pubmed
14762118
uniprot
proteins
pubmed
14960591
uniprot
proteins
pubmed
15471860
uniprot
proteins
pubmed
15537887
uniprot
proteins
pubmed
15708491
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20064394
uniprot
proteins
pubmed
22850675
uniprot
proteins
pubmed
9368048
uniprot
proteins
sequence_length
512
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11306621, ECO:0000269|PubMed:15537887, ECO:0000269|PubMed:15708491}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q16515}. Note=Localized at the plasma membrane, in the soma and punctated peripheral processes of neurons. {ECO:0000269|PubMed:11306621}.
uniprot
proteins
transmembrane_region
TRANSMEM 38..58; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 428..448; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins