Pdx1
entrez
18609
canonical
uniprot
P52946
canonical
ensembl
ENSMUSG00000029644
resolver
ensp
ENSMUSP00000082729
resolver
enst
ENSMUST00000085591
resolver
genesymbol
Pdx1
resolver
genesymbol_syn
Ipf1
resolver
uniprot
Q3ZB03
resolver
uniprot_entry
PDX1_MOUSE
resolver
uniprot_sec
Q3ZB03
resolver
amino_acid_sequence
MNSEEQYYAATQLYKDPCAFQRGPVPEFSANPPACLYMGRQPPPPPPPQFTSSLGSLEQGSPPDISPYEVPPLASDDPAGAHLHHHLPAQLGLAHPPPGPFPNGTEPGGLEEPNRVQLPFPWMKSTKAHAWKGQWAGGAYTAEPEENKRTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKWKKEEDKKRSSGTPSGGGGGEEPEQDCAVTSGEELLAVPPLPPPGGAVPPGVPAAVREGLLPSGLSVSPQPSSIAPLRPQEPR
uniprot
proteins
function
FUNCTION: Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. Binds the DNA sequence 5'-CC[CT]TAATGGG-3'. {ECO:0000269|PubMed:11279116, ECO:0000269|PubMed:12219087, ECO:0000269|PubMed:9710595}.
uniprot
proteins
mass_dalton
30999
uniprot
proteins
mutagenesis
MUTAGEN 152; /note="T->D,E: Displays a more cytosolic distribution."; /evidence="ECO:0000269|PubMed:17052199"; MUTAGEN 269; /note="S->A: Reduced phosphorylation by HIPK2."; /evidence="ECO:0000269|PubMed:20637728"; MUTAGEN 269; /note="S->E: Abnormal subnuclear localization upon glucose accumulation."; /evidence="ECO:0000269|PubMed:20637728
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by the SAPK2 pathway at high intracellular glucose concentration. Phosphorylated by HIPK2 on Ser-269 upon glucose accumulation. This phosphorylation mediates subnuclear localization shifting. Phosphorylation by PASK may lead to translocation into the cytosol. {ECO:0000269|PubMed:17052199, ECO:0000269|PubMed:20637728}.
uniprot
proteins
protein_family
Antp homeobox family
uniprot
proteins
protein_family
IPF1/XlHbox-8 subfamily
uniprot
proteins
pubmed
11279116
uniprot
proteins
pubmed
12219087
uniprot
proteins
pubmed
15121856
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17052199
uniprot
proteins
pubmed
20637728
uniprot
proteins
pubmed
7901001
uniprot
proteins
pubmed
9710595
uniprot
proteins
sequence_length
284
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:17052199}. Cytoplasm, cytosol {ECO:0000269|PubMed:17052199}.
uniprot
proteins