Ercc6l2
entrez
76251
canonical
uniprot
Q9JIM3
canonical
ensembl
ENSMUSG00000021470
resolver
ensp
ENSMUSP00000021926
resolver
ensp
ENSMUSP00000069488
resolver
ensp
ENSMUSP00000158755
resolver
ensp
ENSMUSP00000203633
resolver
ensp
ENSMUSP00000203639
resolver
ensp
ENSMUSP00000203640
resolver
genesymbol
Ercc6l2
resolver
genesymbol_syn
Rad26l
resolver
uniprot
E9Q4J6
resolver
uniprot
Q6DI94
resolver
uniprot
Q8BIV4
resolver
uniprot
Q8BM40
resolver
uniprot
Q8K267
resolver
uniprot
Q8R2Z6
resolver
uniprot
Q9DA70
resolver
uniprot
Q9DD01
resolver
uniprot_entry
ER6L2_MOUSE
resolver
uniprot_sec
E9Q4J6
resolver
uniprot_sec
Q6DI94
resolver
uniprot_sec
Q8BIV4
resolver
uniprot_sec
Q8BM40
resolver
uniprot_sec
Q8K267
resolver
uniprot_sec
Q8R2Z6
resolver
uniprot_sec
Q9DA70
resolver
uniprot_sec
Q9DD01
resolver
amino_acid_sequence
MDISAPQSRADSRKDRWCPGERCLAPSLDNKKLCEASIKSITVDGNGKPFAVVLYPDFQEKTIPLQRLQEVKSTKDYSRSLIFDDKDLEKPYFPDRKIPSLASAFQLSEDGDSIPYTINRYLRDYQREGAQFLYRHYIEGRGCILGDDMGLGKTIQVISFLAAVLHKKGTREDIENNMPEFLLKSMKKKPPSTAKKMFLIVAPLSVLYNWKDELDTWGYFRVTVLHGSKKDNELLRLKQRKCEIALTTYETLRLCLEELNSLEWSAIIVDEAHRIKNPKARVTEVMKAVKCKVRIGLTGTVLQNNMKELWCVMDWAVPGLLGSRIHFKKQFSDPVEHGQRHTATKRELATGRKAMHRLAKKMSGWFLRRTKTLIKGQLPKKEDRMVYCSLTDFQKAVYQTVLETEDVALILTSSQPCTCGSGQKRRKCCYKTNSRGDTVRTLCLSYLTVLQKVANHVALLQAASTSKHQETVIKRICDRVFSRFPDFVQKSKDAAFETLSDPKYSGKMKVLQQLLNHFRKQRDKVLLFSFSTKLLDVLQQYCMASGLDYRRLDGSTKSEERLKIVKEFNSSQDVNICLVSTMAGGLGLNFVGANVVILFDPTWNPANDLQAVDRAYRIGQCRDVKVLRLISLGTVEEIMYLRQVYKQQLHCVVVGSENAKRYFEAVQGSKEHRGELFGVHNLFKLRSQGSCLTRDILEREGQVEAGIMTATTWLKGEPSAQELETPRDPDCQEPTDVCELYSDISDEESVGHSLGKTDKHKFSDTSRTPGFPAQLTLLQCGFSKLFEAKYKSDQDGDGNPVPSDGSSDEQPMCLSAEARQAARQKTWDSVCTSEHQKSDNIQTPDEKCVSDKSEKTLEQNVSSESDDETKDHRTAGHHCMGQGDTESEDSDVIFPTQYPTQRIPKNHIRFKLLLGESEDSEAENPVKVNHGDDRQNSGRGNGPVPNLLCLENMTSKSVRKRKGTDDISDESDDIDMFPKSRIRKQRATTSLKFKRKKENKRKLDNSPVTAKEANQVCAADGDRSSQVIEDFSSSDDNLSLSHLSFTKLSHRAETVKDKISLSPKLPGPDKKNNTFISRKPPSFLNEGVISQEQICNSMDKILDGVQEVAYIHSNQNVIGSSRAENHMSRWATRDVFELKQFSQLPANVAVCSSKTYKTQVKANIVSPTEKDQPPSDGGISSPLYVSHPVVQKKKDVYRTNHTTFIIGETPRGIRRKQFEEMASYYKLPVKEFAEQVTRATSEERQKMLRDFYSLQHPEVKEFFVNSASELIKSVHKKEERVRNKSKEKESLLKENPSNDSTLSCYDSTNKMSQVYNRKICEGKSVRSQNHVFHREDTFSSDAEINKSPVSFTEELHSERKDHTPKDTTTVFCPNSNSEALEAELGNSPGRQWDLTGACGSRNRPLFKLRNKRVENPGSENTPEDGLLGDTSILNDLFKSHGEGPTQLPKNVLSGPVAKAKQKPKDFWDILNEQNDDSLSKLTDLAVIETLCTKAPSTSASKRKDELEASLWKANEKFLWKTLSSDVDDESISNTERE
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: Promotes double-strand break (DSB) end-joining and facilitates programmed recombination by controlling how DNA ends are joined in a spatially oriented manner during repair (PubMed:32355287). Also plays a role in DNA repair by restricting DNA end resection in double strand break (DSB) repair. Facilitates replication of complex DNA regions and regulates the maintenance of chromatin structure (By similarity). {ECO:0000250|UniProtKB:Q5T890, ECO:0000269|PubMed:32355287}.
uniprot
proteins
mass_dalton
173873
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by NEK6. {ECO:0000250|UniProtKB:Q5T890}.
uniprot
proteins
protein_family
SNF2/RAD54 helicase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32355287
uniprot
proteins
sequence_length
1537
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5T890}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q5T890}. Mitochondrion {ECO:0000250|UniProtKB:Q5T890}. Chromosome, centromere {ECO:0000250|UniProtKB:Q5T890}. Note=Colocalizes with NEK6 in the centrosome. In response to DNA damage, translocates from the cytosol to mitochondria and nucleus in a reactive oxygen species (ROS)-dependent manner. Centromeric localization is facilitated by its interaction with PCNA. {ECO:0000250|UniProtKB:Q5T890}.
uniprot
proteins