Rbmx
entrez
19655
canonical
uniprot
Q9WV02
canonical
ensembl
ENSMUSG00000031134
resolver
ensp
ENSMUSP00000110374
resolver
ensp
ENSMUSP00000110378
resolver
ensp
ENSMUSP00000244185
resolver
ensp
ENSMUSP00000244197
resolver
genesymbol
Rbmx
resolver
genesymbol_syn
Hnrnpg
resolver
genesymbol_syn
Hnrpg
resolver
genesymbol_syn
Rbmxp1
resolver
genesymbol_syn
Rbmxrt
resolver
uniprot
Q8C2U6
resolver
uniprot
Q9R0Y0
resolver
uniprot_entry
RBMX_MOUSE
resolver
uniprot_sec
Q8C2U6
resolver
uniprot_sec
Q9R0Y0
resolver
amino_acid_sequence
MVEADRPGKLFIGGLNTETNEKALEAVFGKYGRIVEVLLMKDRETNKSRGFAFVTFESPADAKDAARDMNGKSLDGKAIKVEQATKPSFESGRRGLPPPPRSRGPPRGLRGGRGGSGGTRGPPSRGGHMDDGGYSMNFTMSSSRGPLPVKRGPPPRSGGPPPKRSAPSGPVRSSSGLGGRAPVSRGRDGYGGPPRREPLPSRRDVYLSPRDDGYSTKDSYSSREYPSSRDTRDYAPPPRDYTYRDYGHSSSRDDYPSRGYSDRDGYGRDRDYSDHPSGGSYRDSYESYGNSRSAPPTRGPPPSYGGSSRYDDYSSSRDGYGGSRDSYSSSRSDLYSSGRDRVGRQERGLPPSMERGYPPPRDSYSSSSRGAPRGGGRGGSRSDRGGGRSRY
uniprot
proteins
function
FUNCTION: RNA-binding protein that plays several role in the regulation of pre- and post-transcriptional processes. Implicated in tissue-specific regulation of gene transcription and alternative splicing of several pre-mRNAs. Binds to and stimulates transcription from the tumor suppressor TXNIP gene promoter; may thus be involved in tumor suppression. When associated with SAFB, binds to and stimulates transcription from the SREBF1 promoter. Associates with nascent mRNAs transcribed by RNA polymerase II. Component of the supraspliceosome complex that regulates pre-mRNA alternative splice site selection. Can either activate or suppress exon inclusion; acts additively with TRA2B to promote exon 7 inclusion of the survival motor neuron SMN2. Represses the splicing of MAPT/Tau exon 10. Binds preferentially to single-stranded 5'-CC[A/C]-rich RNA sequence motifs localized in a single-stranded conformation; probably binds RNA as a homodimer. Binds non-specifically to pre-mRNAs. Also plays a role in the cytoplasmic TNFR1 trafficking pathways; promotes both the IL-1-beta-mediated inducible proteolytic cleavage of TNFR1 ectodomains and the release of TNFR1 exosome-like vesicles to the extracellular compartment. {ECO:0000269|PubMed:17188681, ECO:0000269|PubMed:19403048}.
uniprot
proteins
mass_dalton
42301
uniprot
proteins
post_translational_modification
PTM: O-glycosylated. {ECO:0000250}.; PTM: Arg-182 is dimethylated, probably to asymmetric dimethylarginine.
uniprot
proteins
pubmed
10391207
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17188681
uniprot
proteins
pubmed
19403048
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
391
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Note=Localizes in numerous small granules in the nucleus (By similarity). Component of ribonucleosomes. {ECO:0000250}.
uniprot
proteins