SNU13
entrez
4809
canonical
uniprot
P55769
canonical
ensembl
ENSG00000100138
resolver
ensp
ENSP00000215956
resolver
ensp
ENSP00000383949
resolver
ensp
ENSP00000497142
resolver
enst
ENST00000215956
resolver
enst
ENST00000401959
resolver
enst
ENST00000648674
resolver
genesymbol
NHP2L1
resolver
genesymbol
SNU13
resolver
genesymbol_syn
NHP2L1
resolver
hgnc
HGNC:7819
resolver
uniprot
Q6FHM6
resolver
uniprot_entry
NH2L1_HUMAN
resolver
uniprot_entry
Q6FHM6_HUMAN
resolver
amino_acid_sequence
MTEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANEATKTLNRGISEFIVMAADAEPLEIILHLPLLCEDKNVPYVFVRSKQALGRACGVSRPVIACSVTIKEGSQLKQQIQSIQQSIERLLV
uniprot
proteins
function
FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:28781166). Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly (PubMed:10545122, PubMed:17412961). The protein undergoes a conformational change upon RNA-binding (PubMed:10545122, PubMed:17412961, PubMed:28781166). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:39570315). {ECO:0000269|PubMed:10545122, ECO:0000269|PubMed:17412961, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}.
uniprot
proteins
mass_dalton
14174
uniprot
proteins
mutagenesis
MUTAGEN 38; /note="G->K: Abolishes U4 snRNA-binding."; /evidence="ECO:0000269|PubMed:10545122"; MUTAGEN 57; /note="A->F: Abolishes U4 snRNA-binding."; /evidence="ECO:0000269|PubMed:10545122"; MUTAGEN 80; /note="Y->A: Reduces U4 snRNA-binding by about 50%."; /evidence="ECO:0000269|PubMed:10545122"; MUTAGEN 96..128; /note="Missing: Abolishes U4 snRNA-binding."; /evidence="ECO:0000269|PubMed:10545122
uniprot
proteins
protein_family
Eukaryotic ribosomal protein eL8 family
uniprot
proteins
pubmed
10545122
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
10593953
uniprot
proteins
pubmed
11163207
uniprot
proteins
pubmed
12429849
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16723661
uniprot
proteins
pubmed
17412961
uniprot
proteins
pubmed
18044964
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21784869
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26912367
uniprot
proteins
pubmed
28781166
uniprot
proteins
pubmed
34516797
uniprot
proteins
pubmed
39570315
uniprot
proteins
pubmed
8978773
uniprot
proteins
sequence_length
128
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166, ECO:0000269|PubMed:34516797}. Nucleus, nucleolus {ECO:0000269|PubMed:10593953, ECO:0000269|PubMed:12429849, ECO:0000269|Ref.7}. Note=Concentrated in the dense fibrillar component of the nucleolus. {ECO:0000269|PubMed:10593953}.
uniprot
proteins