Mbl2
entrez
64668
canonical
uniprot
P08661
canonical
ensembl
ENSRNOG00000011637
resolver
ensp
ENSRNOP00000047103
resolver
enst
ENSRNOT00000050984
resolver
genesymbol
Mbl2
resolver
uniprot_entry
MBL2_RAT
resolver
amino_acid_sequence
MSLFTSFLLLCVLTAVYAETLTEGAQSSCPVIACSSPGLNGFPGKDGHDGAKGEKGEPGQGLRGLQGPPGKVGPAGPPGNPGSKGATGPKGDRGESVEFDTTNIDLEIAALRSELRAMRKWVLLSMSENVGKKYFMSSVRRMPLNRAKALCSELQGTVATPRNAEENRAIQNVAKDVAFLGITDQRTENVFEDLTGNRVRYTNWNEGEPNNVGSGENCVVLLTNGKWNDVPCSDSFLVVCEFSD
uniprot
proteins
function
FUNCTION: Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:11850428, PubMed:3009480, PubMed:8557671). Specifically recognizes and binds the mannose moiety of carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway (PubMed:11850428, PubMed:8557671). {ECO:0000269|PubMed:11850428, ECO:0000269|PubMed:3009480, ECO:0000269|PubMed:8557671}.
uniprot
proteins
mass_dalton
26014
uniprot
proteins
pubmed
10903744
uniprot
proteins
pubmed
11850428
uniprot
proteins
pubmed
1607365
uniprot
proteins
pubmed
22167201
uniprot
proteins
pubmed
3009480
uniprot
proteins
pubmed
3032924
uniprot
proteins
pubmed
8557671
uniprot
proteins
pubmed
9922165
uniprot
proteins
sequence_length
244
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10903744}. Cell surface {ECO:0000250|UniProtKB:P11226}. Note=Specifically binds mannose moiety of carbohydrates on the surface of pathogens. {ECO:0000250|UniProtKB:P11226}.
uniprot
proteins