Tnfrsf11b
entrez
25341
canonical
uniprot
O08727
canonical
ensembl
ENSRNOG00000008336
resolver
ensembl
ENSRNOG00055021809
resolver
ensembl
ENSRNOG00060003483
resolver
ensembl
ENSRNOG00065014913
resolver
ensp
ENSRNOP00000011344
resolver
ensp
ENSRNOP00055030475
resolver
ensp
ENSRNOP00060004177
resolver
ensp
ENSRNOP00065019256
resolver
enst
ENSRNOT00000011344
resolver
enst
ENSRNOT00055037391
resolver
enst
ENSRNOT00060005719
resolver
enst
ENSRNOT00065024668
resolver
genesymbol
Tnfrsf11b
resolver
genesymbol_syn
Opg
resolver
uniprot_entry
TR11B_RAT
resolver
amino_acid_sequence
MNKWLCCALLVFLDIIEWTTQETFPPKYLHYDPETGRQLLCDKCAPGTYLKQHCTVRRKTLCVPCPDYSYTDSWHTSDECVYCSPVCKELQTVKQECNRTHNRVCECEEGRYLELEFCLKHRSCPPGLGVLQAGTPERNTVCKRCPDGFFSGETSSKAPCRKHTNCSSLGLLLIQKGNATHDNVCSGNREATQNCGIDVTLCEEAFFRFAVPTKIIPNWLSVLVDSLPGTKVNAESVERIKRRHSSQEQTFQLLKLWKHQNRDQEMVKKIIQDIDLCESSVQRHIGHANLTTEQLRILMESLPGKKISPDEIERTRKTCKPSEQLLKLLSLWRIKNGDQDTLKGLMYALKHLKAYHFPKTVTHSLRKTIRFLHSFTMYRLYQKLFLEMIGNQVQSVKISCL
uniprot
proteins
function
FUNCTION: Acts as a decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
46192
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9108485
uniprot
proteins
sequence_length
401
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
uniprot
proteins