Txnrd3
entrez
232223
canonical
uniprot
Q99MD6
canonical
ensembl
ENSMUSG00000000811
resolver
ensp
ENSMUSP00000000828
resolver
ensp
ENSMUSP00000098730
resolver
genesymbol
Txnrd3
resolver
genesymbol_syn
Tgr
resolver
genesymbol_syn
Trxr3
resolver
uniprot
Q3UY43
resolver
uniprot
Q9CZE5
resolver
uniprot_entry
Q3UY43_MOUSE
resolver
uniprot_entry
TRXR3_MOUSE
resolver
uniprot_sec
Q9CZE5
resolver
amino_acid_sequence
MEKPPSPPPPPRAQTSPGLGKVGVLPNRRLGAVRGGLMSSPPGRRARLASPGTSRPSSEAREELRRRLRDLIEGNRVMIFSKSYCPHSTRVKELFSSLGVVYNILELDQVDDGASVQEVLTEISNQKTVPNIFVNKVHVGGCDRTFQAHQNGLLQKLLQDDSAHDYDLIIIGGGSGGLSCAKEAANLGKKVMVLDFVVPSPQGTTWGLGGTCVNVGCIPKKLMHQAALLGHALQDAKKYGWEYNQQVKHNWEAMTEAIQSHIGSLNWGYRVTLREKGVTYVNSFGEFVDLHKIKATNKKGQETFYTASKFVIATGERPRYLGIQGDKEYCITSDDLFSLPYCPGCTLVVGASYVGLECAGFLAGLGLDVTVMVRSVLLRGFDQEMAEKVGSYLEQQGVKFQRKFTPILVQQLEKGLPGKLKVVAKSTEGPETVEGIYNTVLLAIGRDSCTRKIGLEKIGVKINEKNGKIPVNDVEQTNVPHVYAIGDILDGKPELTPVAIQAGKLLARRLFGVSLEKCDYINIPTTVFTPLEYGCCGLSEEKAIEMYKKENLEVYHTLFWPLEWTVAGRDNNTCYAKIICNKFDNERVVGFHLLGPNAGEITQGFAAAMKCGLTKQLLDDTIGIHPTCGEVFTTLEITKSSGLDITQKGCUG
uniprot
proteins
ec_number
1.8.1.9
uniprot
proteins
function
FUNCTION: Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components. {ECO:0000269|PubMed:11259642, ECO:0000269|PubMed:15901730}.
uniprot
proteins
mass_dalton
71319
uniprot
proteins
mutagenesis
MUTAGEN 651..652; /note="Missing: Abolishes thioredoxin reductase, glutaredoxin and gluthioine reductase activities."; /evidence="ECO:0000269|PubMed:16262253"; MUTAGEN 651; /note="U->C: Thioredoxin reductase activity reduced to 21%. Glutaredoxin activity reduced to 14%. Glutathione reductase activity reduced to 18%."; /evidence="ECO:0000269|PubMed:16262253"; MUTAGEN 651; /note="U->S: Abolishes thioredoxin reductase, glutaredoxin and gluthioine reductase activities."; /evidence="ECO:0000269|PubMed:16262253
uniprot
proteins
protein_family
Class-I pyridine nucleotide-disulfide oxidoreductase family
uniprot
proteins
pubmed
10455115
uniprot
proteins
pubmed
11259642
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15901730
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16262253
uniprot
proteins
pubmed
20018845
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
652
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11259642, ECO:0000269|PubMed:15901730}. Nucleus {ECO:0000269|PubMed:11259642, ECO:0000269|PubMed:15901730}. Microsome {ECO:0000269|PubMed:11259642, ECO:0000269|PubMed:15901730}. Endoplasmic reticulum. Note=Detected in cytoplasm and nucleus in late spermatids. {ECO:0000269|PubMed:11259642, ECO:0000269|PubMed:15901730}.
uniprot
proteins