TSSK1
entrez
83942
canonical
uniprot
Q9BXA7
canonical
ensembl
ENSG00000212122
resolver
ensp
ENSP00000375081
resolver
enst
ENST00000390666
resolver
genesymbol
TSSK1
resolver
genesymbol
TSSK1B
resolver
genesymbol_syn
SPOGA1
resolver
genesymbol_syn
SPOGA4
resolver
genesymbol_syn
STK22A
resolver
genesymbol_syn
STK22D
resolver
genesymbol_syn
TSSK1
resolver
hgnc
HGNC:14968
resolver
uniprot
A0ZT98
resolver
uniprot
B2R8D9
resolver
uniprot_entry
A0ZT98_HUMAN
resolver
uniprot_entry
TSSK1_HUMAN
resolver
uniprot_sec
B2R8D9
resolver
activity_regulation
ACTIVITY REGULATION: Kinase activity is specifically inhibited by 2 classes of compounds: biphenyl compounds (1,1'-(biphenyl-4,4'-diyl)bis(2,2-dihydroxyethanone)) and 1,2,7-trialky-1H-imidazo[4,5-g]quinoxalin-6-one. Activated by phosphorylation on Thr-174 and potentially by autophosphorylation. {ECO:0000269|PubMed:15733851, ECO:0000269|PubMed:19530700}.
uniprot
proteins
amino_acid_sequence
MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPREIEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQLSLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPAYAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKHLTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKARGSPSVAINKEGESSRGTEPLWTPEPGSDKKSATKLEPEGEAQPQAQPETKPEGTAMQMSRQSEILGFPSKPSTMETEEGPPQQPPETRAQ
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates 'Ser-288' of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. {ECO:0000269|PubMed:15733851, ECO:0000269|PubMed:19530700}.
uniprot
proteins
mass_dalton
41618
uniprot
proteins
mutagenesis
MUTAGEN 174; /note="T->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:15733851"; MUTAGEN 174; /note="T->E: Constitutively active."; /evidence="ECO:0000269|PubMed:15733851
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. {ECO:0000269|PubMed:15733851}.; PTM: Ubiquitinated; HSP90 activity negatively regulates ubiquitination and degradation. {ECO:0000250|UniProtKB:Q61241}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15044604
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15733851
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17566264
uniprot
proteins
pubmed
19530700
uniprot
proteins
pubmed
20729278
uniprot
proteins
sequence_length
367
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}. Cell projection, cilium, flagellum {ECO:0000250}. Note=In spermatozoa, present in the sperm head and in the flagellum. {ECO:0000250}.
uniprot
proteins