Ormdl2
entrez
66844
canonical
uniprot
Q9CQZ0
canonical
ensembl
ENSMUSG00000025353
resolver
ensp
ENSMUSP00000026409
resolver
ensp
ENSMUSP00000151335
resolver
ensp
ENSMUSP00000151697
resolver
ensp
ENSMUSP00000300555
resolver
genesymbol
Ormdl2
resolver
uniprot
Q8CF72
resolver
uniprot
Q9CSJ7
resolver
uniprot
Q9CVL6
resolver
uniprot_entry
ORML2_MOUSE
resolver
uniprot_sec
Q8CF72
resolver
uniprot_sec
Q9CSJ7
resolver
uniprot_sec
Q9CVL6
resolver
amino_acid_sequence
MNVGVAHSEVNPNTRVMNSRGIWLAYIILVGLLHVVLLSIPFFSIPVVWTLTNVIHNLAMYIFLHTVKGTPFETPDQGKARLLTHWEQMDYGLQFTSSRKFLSISPIVLYLLASFYTKYDAAHFLINTASLLSVLLPKLPQFHGVRLFGINKY
uniprot
proteins
function
FUNCTION: Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels (PubMed:31880535). When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis (By similarity). {ECO:0000250|UniProtKB:Q8N138, ECO:0000269|PubMed:31880535}.
uniprot
proteins
mass_dalton
17390
uniprot
proteins
protein_family
ORM family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31880535
uniprot
proteins
sequence_length
153
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q53FV1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q53FV1}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 43..63; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 106..126; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins