Kmt5c
entrez
232811
canonical
uniprot
Q6Q783
canonical
ensembl
ENSMUSG00000059851
resolver
ensp
ENSMUSP00000096452
resolver
ensp
ENSMUSP00000104223
resolver
ensp
ENSMUSP00000104224
resolver
ensp
ENSMUSP00000216745
resolver
ensp
ENSMUSP00000216748
resolver
ensp
ENSMUSP00000216757
resolver
ensp
ENSMUSP00000331876
resolver
ensp
ENSMUSP00000331887
resolver
enst
ENSMUST00000098853
resolver
enst
ENSMUST00000108582
resolver
enst
ENSMUST00000108583
resolver
genesymbol
Kmt5c
resolver
genesymbol_syn
Suv420h2
resolver
uniprot
Q5RKP6
resolver
uniprot
Q8R1C5
resolver
uniprot_entry
KMT5C_MOUSE
resolver
uniprot_sec
Q5RKP6
resolver
uniprot_sec
Q8R1C5
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by 6,7-Dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine (A-196). {ECO:0000250|UniProtKB:Q86Y97}.
uniprot
proteins
amino_acid_sequence
MGPDRVTARELCENDDLATSLVLDPYLGFRTHKMNVSPVPTLRRQHHLRSALEAFLRQRDLEAAFRALTLGGWMAHYFQSRAPRQEAALKTHIFCYLRAFLPESGFTILPCTRYSMETNGAKIVSTRAWKKNEKLELLVGCIAELREEDEDLLRAGENDFSIMYSTRKRSAQLWLGPAAFINHDCKPNCKFVPSDGNTACVKVLRDIEPGDEVTCFYGEGFFGEKNEHCECYTCERKGEGAFRLQPREPELRPKPLDKYELRETKRRLQQGLVSSQQSLMSRWACSHLSPLRPDPFCAACQPSCLLPASPHMDYLPLWLQRAPQPQPIVPPRKRHRRRRPRIRQASLPPVLRTACVPLHRWGGCGPHCQLRAEAMVTLHLRPQTRWTPQQDWYWARRYGLPSVGRVELTRLAPALPAAPAPAGNPGPVPTPDFIPKQALAFAPFCPPKRLRLVVSHGSIDLDINSGEP
uniprot
proteins
ec_number
2.1.1.361
uniprot
proteins
ec_number
2.1.1.362
uniprot
proteins
function
FUNCTION: Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:15145825, PubMed:28114273). In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression (PubMed:15145825). Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions (PubMed:15145825). KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (PubMed:15750587, PubMed:16612004). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273). {ECO:0000250|UniProtKB:Q86Y97, ECO:0000269|PubMed:15145825, ECO:0000269|PubMed:15750587, ECO:0000269|PubMed:16612004, ECO:0000269|PubMed:28114273}.
uniprot
proteins
mass_dalton
53159
uniprot
proteins
mutagenesis
MUTAGEN 116; /note="M->S: Does not affect affinity for S-adenosyl-L-methionine."; /evidence="ECO:0000269|PubMed:24049080"; MUTAGEN 161; /note="S->A: Does not methylate either an unmodified or monomethylated H4K20 substrate. Methylates a di-methylated H4K20 peptide."; /evidence="ECO:0000269|PubMed:24049080
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
Histone-lysine methyltransferase family
uniprot
proteins
protein_family
Suvar4-20 subfamily
uniprot
proteins
pubmed
15145825
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15750587
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16612004
uniprot
proteins
pubmed
24049080
uniprot
proteins
pubmed
28114273
uniprot
proteins
sequence_length
468
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15145825}. Chromosome {ECO:0000269|PubMed:15145825}. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin.
uniprot
proteins