Acer3
entrez
66190
canonical
uniprot
Q9D099
canonical
ensembl
ENSMUSG00000030760
resolver
ensp
ENSMUSP00000033020
resolver
ensp
ENSMUSP00000112884
resolver
enst
ENSMUST00000033020
resolver
enst
ENSMUST00000120520
resolver
genesymbol
Acer3
resolver
genesymbol_syn
Aphc
resolver
genesymbol_syn
Phca
resolver
uniprot
D3YTU8
resolver
uniprot
Q542R2
resolver
uniprot
Q9D0X4
resolver
uniprot
Q9D3J4
resolver
uniprot_entry
ACER3_MOUSE
resolver
uniprot_entry
D3YTU8_MOUSE
resolver
uniprot_sec
Q542R2
resolver
uniprot_sec
Q9D0X4
resolver
uniprot_sec
Q9D3J4
resolver
activity_regulation
ACTIVITY REGULATION: Activated by Ca(2+) and inhibited by Zn(2+). {ECO:0000250|UniProtKB:Q9NUN7}.
uniprot
proteins
amino_acid_sequence
MAPAVDRKGYWGPTTSTLDWCEENYVVTLFVAEFWNTVSNLIMIIPPIFGAIQGIRDRLEKRYIAAYLALTVVGMGSWCFHMTLKYEMQLLDELPMIYSCCIFVYCMFECFKTKSSINYHLLFTLFLYSLTVTTIYLKVKEPIFHQVMYGMLVFTLVLRSIYIVTWVYPWLRGLGYTSLTVFLLGFLLWNIDNIFCDSLRNFRKRVPPVLGVTTQFHAWWHILTGLGSYLHILFSLYTRTLYLRYRPKVKFLFGIWPAVMFEPQRKH
uniprot
proteins
ec_number
3.5.1.-
uniprot
proteins
ec_number
3.5.1.23
uniprot
proteins
function
FUNCTION: Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4-ceramides, dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH (PubMed:26474409). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:26474409). Controls the generation of sphingosine in erythrocytes, and thereby sphingosine-1-phosphate in plasma (By similarity). Through the regulation of ceramides and sphingosine-1-phosphate homeostasis in the brain may play a role in neurons survival and function (PubMed:26474409). By regulating the levels of pro-inflammatory ceramides in immune cells and tissues, may modulate the inflammatory response (PubMed:26938296). {ECO:0000250|UniProtKB:Q9NUN7, ECO:0000269|PubMed:26474409, ECO:0000269|PubMed:26938296, ECO:0000303|PubMed:26474409}.
uniprot
proteins
mass_dalton
31565
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; sphingolipid metabolism. {ECO:0000269|PubMed:26474409}.
uniprot
proteins
protein_family
Alkaline ceramidase family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
26474409
uniprot
proteins
pubmed
26938296
uniprot
proteins
sequence_length
267
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9NUN7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NUN7}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9NUN7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NUN7}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..55; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NUN7"; TRANSMEM 62..82; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NUN7"; TRANSMEM 88..108; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NUN7"; TRANSMEM 119..139; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NUN7"; TRANSMEM 142..162; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NUN7"; TRANSMEM 174..194; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NUN7"; TRANSMEM 216..236; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NUN7
uniprot
proteins