TCF7L1
entrez
83439
canonical
uniprot
Q9HCS4
canonical
ensembl
ENSG00000152284
resolver
ensembl
ENSG00000292149
resolver
ensp
ENSP00000282111
resolver
ensp
ENSP00000517899
resolver
ensp
ENSP00000538161
resolver
enst
ENST00000282111
resolver
enst
ENST00000709854
resolver
genesymbol
TCF7L1
resolver
genesymbol_syn
TCF3
resolver
hgnc
HGNC:11640
resolver
uniprot
Q53R97
resolver
uniprot
Q6PD70
resolver
uniprot
Q9NP00
resolver
uniprot_entry
TF7L1_HUMAN
resolver
uniprot_sec
Q53R97
resolver
uniprot_sec
Q6PD70
resolver
uniprot_sec
Q9NP00
resolver
amino_acid_sequence
MPQLGGGGGGGGGGSGGGGGSSAGAAGGGDDLGANDELIPFQDEGGEEQEPSSDSASAQRDLDEVKSSLVNESENQSSSSDSEAERRPQPVRDTFQKPRDYFAEVRRPQDSAFFKGPPYPGYPFLMIPDLSSPYLSNGPLSPGGARTYLQMKWPLLDVPSSATVKDTRSPSPAHLSNKVPVVQHPHHMHPLTPLITYSNDHFSPGSPPTHLSPEIDPKTGIPRPPHPSELSPYYPLSPGAVGQIPHPLGWLVPQQGQPMYSLPPGGFRHPYPALAMNASMSSLVSSRFSPHMVAPAHPGLPTSGIPHPAIVSPIVKQEPAPPSLSPAVSVKSPVTVKKEEEKKPHVKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRKWHNLSREEQAKYYELARKERQLHSQLYPTWSARDNYGKKKKRKREKQLSQTQSQQQVQEAEGALASKSKKPCVQYLPPEKPCDSPASSHGSMLDSPATPSAALASPAAPAATHSEQAQPLSLTTKPETRAQLALHSAAFLSAKAAASSSGQMGSQPPLLSRPLPLGSMPTALLASPPSFPATLHAHQALPVLQAQPLSLVTKSAH
uniprot
proteins
function
FUNCTION: Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance. {ECO:0000250}.
uniprot
proteins
mass_dalton
62631
uniprot
proteins
protein_family
TCF/LEF family
uniprot
proteins
pubmed
11085512
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
1741298
uniprot
proteins
pubmed
19304756
uniprot
proteins
pubmed
9916915
uniprot
proteins
sequence_length
588
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins