Rnf144b
entrez
218215
canonical
uniprot
Q8BKD6
canonical
ensembl
ENSMUSG00000038068
resolver
ensp
ENSMUSP00000071017
resolver
ensp
ENSMUSP00000105738
resolver
enst
ENSMUST00000068891
resolver
enst
ENSMUST00000110111
resolver
genesymbol
Rnf144b
resolver
genesymbol_syn
Ibrdc2
resolver
uniprot
Q8BG97
resolver
uniprot
Q8R195
resolver
uniprot_entry
R144B_MOUSE
resolver
uniprot_sec
Q8BG97
resolver
uniprot_sec
Q8R195
resolver
amino_acid_sequence
MDSVDGLQCLTMTAENPPSGDLIPAPLVTCKLCLCEQSLDKMTMLQECQCIFCTPCLKQYMVLSIREGCGSPITCPDMVCLNHGTLQETEIACLVPLDEFQLYQRLKFEREVHMDPLRTWCPVADCQTVCHISAGDPGQPVLVECPSCHLKFCSCCKDAWHEESSCRDSQSAMPEHGALFGTDADAPIKQCPVCRIYIERNEGCAQMMCKNCKHTFCWYCLQNLDNDIFLRHYDKGPCRNKLGHSRASVMWNRTQVVGILVGLGVIALVTSPLLLLASPCIICCVCKSCRGKKKKHDPSTT
uniprot
proteins
ec_number
2.3.2.31
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates such as LCMT2, thereby promoting their degradation. Induces apoptosis via a p53/TP53-dependent but caspase-independent mechanism. Plays a crucial role in maintaining the genomic stability by controlling the degradation of multiple proteins involved in mitotic progression and DNA damage. Regulates epithelial homeostasis by mediating degradation of CDKN1A and isoform 2 of TP63. Plays a regulatory role in innate immunity by negatively regulating IRF3 activation and IFN-beta production. Mechanistically, inhibits TBK1 phosphorylation and 'Lys-63'-linked polyubiquitination independently of its E3 ligase activity. Alternatively, promotes 'Lys-27' and 'Lys-33'-linked ubiquitination of IFIH1/MDA5, promoting selective autophagic degradation of IFIH1/MDA5 to inhibit antiviral response (PubMed:39285245). {ECO:0000250|UniProtKB:Q7Z419, ECO:0000269|PubMed:39285245}.
uniprot
proteins
mass_dalton
33495
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated. {ECO:0000250|UniProtKB:Q7Z419}.
uniprot
proteins
protein_family
RBR family
uniprot
proteins
protein_family
RNF144 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
39285245
uniprot
proteins
sequence_length
301
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250|UniProtKB:Q7Z419}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q7Z419}. Cytoplasm {ECO:0000250|UniProtKB:Q7Z419}. Note=Mostly cytosololic, accumulates in submitochondrial domains specifically upon apoptosis induction, in synchrony with BAX activation. {ECO:0000250|UniProtKB:Q7Z419}.
uniprot
proteins
transmembrane_region
TRANSMEM 256..276; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins