Bccip
entrez
66165
canonical
uniprot
Q9CWI3
canonical
ensembl
ENSMUSG00000030983
resolver
ensp
ENSMUSP00000033282
resolver
enst
ENSMUST00000033282
resolver
genesymbol
Bccip
resolver
uniprot
Q9D1E0
resolver
uniprot_entry
BCCIP_MOUSE
resolver
uniprot_sec
Q9D1E0
resolver
amino_acid_sequence
MASKAKKRAVGNGIQRPLGAPGQREEEEEEEDEVEDEEEDEDDSDEEEDEVDEIVDEEVNIEFEAYSISDNDYGGIKKLLQQLFLKAPVNTAELTNLLMQQNHIGSVIKQTDVSEDSDDEVDEDEIFGFISLLNLTERKGTQCAEQIKELVLSFCEKTCEQSMVEQLDKLLNDTSKPVGLLLSERFINVPPQIALPMHQQLQKELSEARRTNKPCGKCCFYLLISKTFMEAGKSSSRKRQDSLQQGALMFANAEEEFFYEKAILKFSYSVQGESDTRLGGRWSFDDVPMTPLRTVMVIPDDRMNEIMETLKDHLSV
uniprot
proteins
function
FUNCTION: During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole (PubMed:28394342). May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ) (By similarity). {ECO:0000250|UniProtKB:Q9P287, ECO:0000269|PubMed:28394342}.
uniprot
proteins
mass_dalton
35942
uniprot
proteins
protein_family
BCP1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28394342
uniprot
proteins
pubmed
35547804
uniprot
proteins
sequence_length
316
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9P287}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:28394342}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:28394342}. Note=Colocalizes with BRCA2 in discrete nuclear foci (By similarity). In interphase, preferential localizes to the mother centriole (PubMed:28394342). Recruited to the spindle pole matrix and centrosome by microtubules and dynein/dynactin activity (By similarity). {ECO:0000250|UniProtKB:Q9P287, ECO:0000269|PubMed:28394342}.
uniprot
proteins