SUSD4
entrez
55061
canonical
uniprot
Q5VX71
canonical
ensembl
ENSG00000143502
resolver
ensp
ENSP00000339926
resolver
ensp
ENSP00000355843
resolver
ensp
ENSP00000477374
resolver
ensp
ENSP00000477432
resolver
ensp
ENSP00000505301
resolver
ensp
ENSP00000505495
resolver
ensp
ENSP00000699625
resolver
enst
ENST00000681285
resolver
genesymbol
SUSD4
resolver
hgnc
HGNC:25470
resolver
uniprot
A0A140VK55
resolver
uniprot
A0A7P0Z457
resolver
uniprot
B3KTY0
resolver
uniprot
D3DTB9
resolver
uniprot
Q6UX62
resolver
uniprot
Q9BSR0
resolver
uniprot
Q9NWG0
resolver
uniprot_entry
A0A140VK55_HUMAN
resolver
uniprot_entry
A0A7P0Z457_HUMAN
resolver
uniprot_entry
B3KTY0_HUMAN
resolver
uniprot_entry
SUSD4_HUMAN
resolver
uniprot_sec
D3DTB9
resolver
uniprot_sec
Q6UX62
resolver
uniprot_sec
Q9BSR0
resolver
uniprot_sec
Q9NWG0
resolver
amino_acid_sequence
MYHGMNPSNGDGFLEQQQQQQQPQSPQRLLAVILWFQLALCFGPAQLTGGFDDLQVCADPGIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQEDCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPICQGCLRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLALEVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEWFPSYQVYCIKSEQTWPSTHETLLTTWKIVAFTATSVLLVLLLVILARMFQTKFKAHFPPRGPPRSSSSDPDFVVVDGVPVMLPSYDEAVSGGLSALGPGYMASVGQGCPLPVDDQSPPAYPGSGDTDTGPGESETCDSVSGSSELLQSLYSPPRCQESTHPASDNPDIIASTAEEVASTSPGIDIADEIPLMEEDP
uniprot
proteins
function
FUNCTION: Acts as a complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative complement pathways. {ECO:0000269|PubMed:23482636}.
uniprot
proteins
mass_dalton
53778
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
23482636
uniprot
proteins
sequence_length
490
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305|PubMed:23482636}.
uniprot
proteins
transmembrane_region
TRANSMEM 320..340; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins