PRDM14
entrez
63978
canonical
uniprot
Q9GZV8
canonical
ensembl
ENSG00000147596
resolver
ensp
ENSP00000276594
resolver
ensp
ENSP00000582685
resolver
ensp
ENSP00000582686
resolver
ensp
ENSP00000582687
resolver
ensp
ENSP00000582688
resolver
ensp
ENSP00000582690
resolver
ensp
ENSP00000582691
resolver
enst
ENST00000276594
resolver
enst
ENST00000912626
resolver
enst
ENST00000912627
resolver
enst
ENST00000912628
resolver
enst
ENST00000912629
resolver
enst
ENST00000912631
resolver
enst
ENST00000912632
resolver
genesymbol
PRDM14
resolver
hgnc
HGNC:14001
resolver
uniprot
Q86UX9
resolver
uniprot_entry
PRD14_HUMAN
resolver
uniprot_sec
Q86UX9
resolver
amino_acid_sequence
MALPRPSEAVPQDKVCYPPESSPQNLAAYYTPFPSYGHYRNSLATVEEDFQPFRQLEAAASAAPAMPPFPFRMAPPLLSPGLGLQREPLYDLPWYSKLPPWYPIPHVPREVPPFLSSSHEYAGASSEDLGHQIIGGDNESGPCCGPDTLIPPPPADASLLPEGLRTSQLLPCSPSKQSEDGPKPSNQEGKSPARFQFTEEDLHFVLYGVTPSLEHPASLHHAISGLLVPPDSSGSDSLPQTLDKDSLQLPEGLCLMQTVFGEVPHFGVFCSSFIAKGVRFGPFQGKVVNASEVKTYGDNSVMWEIFEDGHLSHFIDGKGGTGNWMSYVNCARFPKEQNLVAVQCQGHIFYESCKEIHQNQELLVWYGDCYEKFLDIPVSLQVTEPGKQPSGPSEESAEGYRCERCGKVFTYKYYRDKHLKYTPCVDKGDRKFPCSLCKRSFEKRDRLRIHILHVHEKHRPHKCSTCGKCFSQSSSLNKHMRVHSGDRPYQCVYCTKRFTASSILRTHIRQHSGEKPFKCKYCGKSFASHAAHDSHVRRSHKEDDGCSCSICGKIFSDQETFYSHMKFHEDY
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Transcription factor that has both positive and negative roles on transcription. Required for the maintenance of embryonic stem cell identity and the reacquisition of pluripotency in somatic cells. May play an essential role in germ cell development at 2 levels: the reacquisition of potential pluripotency, including SOX2 up-regulation, and successful epigenetic reprogramming, characterized by EHMT1 repression. Its association with CBFA2T2 is required for the functions in pluripotency and germ cell formation (By similarity). Directly up-regulates the expression of pluripotency gene POU5F1 through its proximal enhancer. Binds to the DNA consensus sequence 5'-GGTC[TC]CTAA-3'. {ECO:0000250|UniProtKB:E9Q3T6, ECO:0000269|PubMed:17942894, ECO:0000269|PubMed:20953172}.
uniprot
proteins
mass_dalton
64062
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17942894
uniprot
proteins
pubmed
20953172
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
27281218
uniprot
proteins
sequence_length
571
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17942894}.
uniprot
proteins