Bscl2
entrez
361722
canonical
uniprot
Q5FVJ6
canonical
ensembl
ENSRNOG00000052393
resolver
ensp
ENSRNOP00000077692
resolver
ensp
ENSRNOP00000095921
resolver
genesymbol
Bscl2
resolver
uniprot_entry
BSCL2_RAT
resolver
amino_acid_sequence
MVNDPPVPALLWAQEVGHVLAGRARRLMLQFGVLFCTILLLLWVSVFLYGSFYYSYMPTVSHLSPVHFYYRTDCDSSTASLCSFPVANVSLTKSGRDRVLMYGQPYRVTLELELPESPVNQDLGMFLVTVSCYTRGGRIISTSSRSVMLHYRSQLLQMLDTLVFSSLLLFGFAEQKQLLEVELYSDYRENSYVPTTGAIIEVHSKRVQMYGAYLRIHAHFTGLRYLLYNFPMTCAFVGVASNFTFLSVIALFSYMQWVWGAVWPRHRFSLQVNIRQRDNSGHGAQRRISRHQPGQASTQQSDVTEDGESPEDPSGTEGQLSEEEKPEKQPLNGEGEQEPEASDGSWEDAALLTEASTSALAPETLGSLRQRQTCSSS
uniprot
proteins
function
FUNCTION: Mediates the formation of lipid droplets during the differentiation and maturation of adipocytes (By similarity). Together with LDAF1, defines the sites of lipid droplet formation in the endoplasmic reticulum and promotes the aggregation of triacylglycerol molecules to form the core of a lipid droplet (nucleation) in the endoplasmic reticulum and drive budding of lipid droplets into the cytoplasm (By similarity). BSCL2 and LDAF1 also regulate protein and lipid delivery from the endoplasmic reticulum into growing lipid droplets: during early adipogenesis, BSCL2 inhibits GPAT3 and GPAT4 activity, thereby preventing phosphatidic acid accumulation that could antagonize PPARG and block differentiation. This inhibition is then relieved by ADIG during adipocyte maturation, allowing expansion of lipid droplets (By similarity). Regulates the maturation of ZFYVE1-positive nascent lipid droplets and the function of the RAB18-ZFYVE1 complex in mediating the formation of endoplasmic reticulum-lipid droplet contacts. Binds anionic phospholipids including phosphatidic acid (By similarity). {ECO:0000250|UniProtKB:Q96G97, ECO:0000250|UniProtKB:Q9Z2E9}.
uniprot
proteins
mass_dalton
42409
uniprot
proteins
protein_family
Seipin family
uniprot
proteins
pubmed
12584444
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
377
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Z2E9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9Z2E9}. Lipid droplet {ECO:0000250|UniProtKB:Q96G97}. Note=Localizes at endoplasmic reticulum-lipid droplets (ER-LD) contact sites. {ECO:0000250|UniProtKB:Q96G97}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..56; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9Z2E9"; TRANSMEM 222..261; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9Z2E9
uniprot
proteins