Hsd17b7
entrez
29540
canonical
uniprot
Q62904
canonical
ensembl
ENSRNOG00000002826
resolver
ensp
ENSRNOP00000003812
resolver
ensp
ENSRNOP00000109240
resolver
enst
ENSRNOT00000159263
resolver
genesymbol
Hsd17b7
resolver
uniprot
A0ABK0LSW1
resolver
uniprot_entry
A0ABK0LSW1_RAT
resolver
uniprot_entry
DHB7_RAT
resolver
amino_acid_sequence
MRKVVLITGASSGIGLALCGRLLAEDDDLHLCLACRNLSKAGAVRDALLASHPSAEVSIVQMDVSNLQSVVRGAEEVKRRFQRLDYLYLNAGIMPNPQLNLKAFFCGIFSRNVIHMFSTAEGLLTQNDKITADGFQEVFETNLFGHFILIRELEPLLCHSDNPSQLIWTSSRNAKKSNFSLEDIQHAKGQEPYSSSKYATDLLNVALNRNFNQKGLYSSVTCPGVVMTNLTYGILPPFVWTLLLPVIWLLRFFAHAFTVTPYNGAEALVWLFHQKPESLNPLTKYLSGTTGLGTNYVKGQKMDVDEDTAEKFYKTLLELEKQVRITIQKSDHHS
uniprot
proteins
ec_number
1.1.1.210
uniprot
proteins
ec_number
1.1.1.270
uniprot
proteins
ec_number
1.1.1.62
uniprot
proteins
function
FUNCTION: Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis (PubMed:6946726, PubMed:9658408). Catalyzes the NADP(H)-dependent reduction of estrogens and androgens and regulates the biological potency of these steroids (By similarity) (PubMed:9658408). Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:9658408). Converts dihydrotestosterone (DHT) to an inactive form. Also participates in the post-squalene cholesterol biosynthesis, as a 3-ketosteroid reductase (By similarity). {ECO:0000250|UniProtKB:P56937, ECO:0000269|PubMed:6946726, ECO:0000269|PubMed:9658408}.
uniprot
proteins
mass_dalton
37372
uniprot
proteins
pathway_participation
PATHWAY: Steroid biosynthesis; estrogen biosynthesis. {ECO:0000269|PubMed:9658408}.; PATHWAY: Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6. {ECO:0000250|UniProtKB:P56937}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000269|PubMed:8663045}.
uniprot
proteins
protein_family
ERG27 subfamily
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
6946726
uniprot
proteins
pubmed
8663045
uniprot
proteins
pubmed
9658408
uniprot
proteins
sequence_length
334
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P56937}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 230..250; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins