TNRC6C
entrez
57690
canonical
uniprot
Q9HCJ0
canonical
ensembl
ENSG00000078687
resolver
ensp
ENSP00000468647
resolver
ensp
ENSP00000512514
resolver
ensp
ENSP00000512702
resolver
ensp
ENSP00000605244
resolver
ensp
ENSP00000605245
resolver
ensp
ENSP00000605247
resolver
ensp
ENSP00000605248
resolver
genesymbol
TNRC6C
resolver
genesymbol_syn
KIAA1582
resolver
hgnc
HGNC:29318
resolver
uniprot
A0A8Q3SIH5
resolver
uniprot
A0A8Q3SIS0
resolver
uniprot
G3XAB8
resolver
uniprot
Q86UE5
resolver
uniprot
Q8N3D8
resolver
uniprot
Q96MU9
resolver
uniprot_entry
TNR6C_HUMAN
resolver
uniprot_sec
A0A8Q3SIH5
resolver
uniprot_sec
A0A8Q3SIS0
resolver
uniprot_sec
G3XAB8
resolver
uniprot_sec
Q86UE5
resolver
uniprot_sec
Q8N3D8
resolver
uniprot_sec
Q96MU9
resolver
amino_acid_sequence
MEEKKKKKQEEKKKKEGAQKKAADQKTKVPEPTKTCSSQPQPAGTSTSTSTSTISSSNNGKRASASGQQPAASRYLPREVPPRFRQQEQKQLLKRGQPLPTGTLTSVSPTQGAGPAGVSPPPLPGAGTQHHPSKLQPDLSHSGLADHYENSHWGQQPTYRSEANCSWDKVIIDRTDKEAWPSITGTETESASECTTDTDSASNCGSENSSMATGSAQGNFTGHTKKTNGNNGTNGALVQSPSNQSALGAGGANSNGSAARVWGVATGSSSGLAHCSVSGGDGKMDTMIGDGRSQNCWGASNSNAGINLNLNPNANPAAWPVLGHEGTVATGNPSSICSPVSAIGQNMGNQNGNPTGTLGAWGNLLPQESTEPQTSTSQNVSFSAQPQNLNTDGPNNTNPMNSSPNPINAMQTNGLPNWGMAVGMGAIIPPHLQGLPGANGSSVSQVSGGSAEGISNSVWGLSPGNPATGNSNSGFSQGNGDTVNSALSAKQNGSSSAVQKEGSGGNAWDSGPPAGPGILAWGRGSGNNGVGNIHSGAWGHPSRSTSNGVNGEWGKPPNQHSNSDINGKGSTGWESPSVTSQNPTVQPGGEHMNSWAKAASSGTTASEGSSDGSGNHNEGSTGREGTGEGRRRDKGIIDQGHIQLPRNDLDPRVLSNTGWGQTPVKQNTAWEFEESPRSERKNDNGTEAWGCAATQASNSGGKNDGSIMNSTNTSSVSGWVNAPPAAVPANTGWGDSNNKAPSGPGVWGDSISSTAVSTAAAAKSGHAWSGAANQEDKSPTWGEPPKPKSQHWGDGQRSNPAWSAGGGDWADSSSVLGHLGDGKKNGSGWDADSNRSGSGWNDTTRSGNSGWGNSTNTKANPGTNWGETLKPGPQQNWASKPQDNNVSNWGGAASVKQTGTGWIGGPVPVKQKDSSEATGWEEPSPPSIRRKMEIDDGTSAWGDPSNYNNKTVNMWDRNNPVIQSSTTTNTTTTTTTTTSNTTHRVETPPPHQAGTQLNRSPLLGPVSSGWGEMPNVHSKTENSWGEPSSPSTLVDNGTAAWGKPPSSGSGWGDHPAEPPVAFGRAGAPVAASALCKPASKSMQEGWGSGGDEMNLSTSQWEDEEGDVWNNAASQESTSSCSSWGNAPKKGLQKGMKTSGKQDEAWIMSRLIKQLTDMGFPREPAEEALKSNNMNLDQAMSALLEKKVDVDKRGLGVTDHNGMAAKPLGCRPPISKESSVDRPTFLDKDGGLVEEPTPSPFLPSPSLKLPLSHSALPSQALGGIASGLGMQNLNSSRQIPSGNLGMFGNSGAAQARTMQQPPQPPVQPLNSSQPSLRAQVPQFLSPQVQAQLLQFAAKNIGLNPALLTSPINPQHMTMLNQLYQLQLAYQRLQIQQQMLQAQRNVSGSMRQQEQQVARTITNLQQQIQQHQRQLAQALLVKQPPPPPPPPHLSLHPSAGKSAMDSFPSHPQTPGLPDLQTKEQQSSPNTFAPYPLAGLNPNMNVNSMDMTGGLSVKDPSQSQSRLPQWTHPNSMDNLPSAASPLEQNPSKHGAIPGGLSIGPPGKSSIDDSYGRYDLIQNSESPASPPVAVPHSWSRAKSDSDKISNGSSINWPPEFHPGVPWKGLQNIDPENDPDVTPGSVPTGPTINTTIQDVNRYLLKSGGSSPPSSQNATLPSSSAWPLSASGYSSSFSSIASAPSVAGKLSDIKSTWSSGPTSHTQASLSHELWKVPRNSTAPTRPPPGLTNPKPSSTWGASPLGWTSSYSSGSAWSTDTSGRTSSWLVLRNLTPQIDGSTLRTLCLQHGPLITFHLNLTQGNAVVRYSSKEEAAKAQKSLHMCVLGNTTILAEFAGEEEVNRFLAQGQALPPTSSWQSSSASSQPRLSAAGSSHGLVRSDAGHWNAPCLGGKGSSELLWGGVPQYSSSLWGPPSADDSRVIGSPTPLTTLLPGDLLSGESL
uniprot
proteins
function
FUNCTION: Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. {ECO:0000269|PubMed:19304925, ECO:0000269|PubMed:21981923, ECO:0000269|PubMed:21984184, ECO:0000269|PubMed:21984185}.
uniprot
proteins
mass_dalton
201830
uniprot
proteins
mutagenesis
MUTAGEN 1501..1507; /note="QSRLPQW->AAAAPAA: Abolishes association with CCR4-NOT complex."; MUTAGEN 1595..1596; /note="EF->AA: Abolishes interaction with PABPC1, impairs interaction with PAN2, no effect on interaction with CCR4-NOT complex, reduces RNA deadenylation rate; when associated with 1395-A-A-1603."; MUTAGEN 1602..1603; /note="WK->AA: Abolishes interaction with PABPC1, impairs interaction with PAN2, no effect on interaction with CCR4-NOT complex, reduces RNA deadenylation rate; when associated with 1388-A-A-1596."; MUTAGEN 1691; /note="W->A: Abolishes translational repression when tethered to a target mRNA, abolishes association with the CCR4-NOT complex; when associated with A-1733, A-1740, A-1750, A-1761, A-1851 and A-1894."; /evidence="ECO:0000269|PubMed:21984184"; MUTAGEN 1733; /note="W->A: Abolishes translational repression when tethered to a target mRNA, abolishes association with the CCR4-NOT complex; when associated with A-1691, A-1740, A-1750, A-1761, A-1851 and A-1894."; /evidence="ECO:0000269|PubMed:21984184"; MUTAGEN 1740; /note="W->A: Abolishes translational repression when tethered to a target mRNA, abolishes association with the CCR4-NOT complex; when associated with A-1691, A-1733, A-1750, A-1761, A-1851 and A-1894."; /evidence="ECO:0000269|PubMed:21984184"; MUTAGEN 1750; /note="W->A: Abolishes translational repression when tethered to a target mRNA, abolishes association with the CCR4-NOT complex; when associated with A-1691, A-1733, A-1740, A-1761, A-1851 and A-1894."; /evidence="ECO:0000269|PubMed:21984184"; MUTAGEN 1761; /note="W->A: Abolishes translational repression when tethered to a target mRNA, abolishes association with the CCR4-NOT complex; when associated with A-1691, A-1733, A-1740, A-1750, A-1851 and A-1894."; /evidence="ECO:0000269|PubMed:21984184"; MUTAGEN 1783; /note="H->A: Strongly reduced ability to repress translation of target mRNAs."; /evidence="ECO:0000269|PubMed:19304925"; MUTAGEN 1789; /note="F->A: Weakly reduced ability to repress translation of target mRNAs."; /evidence="ECO:0000269|PubMed:19304925"; MUTAGEN 1802; /note="Y->A: Strongly reduced ability to repress translation of target mRNAs."; /evidence="ECO:0000269|PubMed:19304925"; MUTAGEN 1851; /note="W->A: Abolishes translational repression when tethered to a target mRNA, abolishes association with the CCR4-NOT complex; when associated with A-1691, A-1733, A-1740, A-1750, A-1761 and A-1894."; /evidence="ECO:0000269|PubMed:21984184"; MUTAGEN 1893..1895; /note="LWG->AAA: Impairs interaction with the CCR4-NOT complex, no effect on interaction with PABPC1; when associated with 1658-A-A-1906."; MUTAGEN 1894; /note="W->A: Abolishes translational repression when tethered to a target mRNA, abolishes association with the CCR4-NOT complex; when associated with A-1691, A-1733, A-1740, A-1750, A-1761 and A-1851."; /evidence="ECO:0000269|PubMed:21984184"; MUTAGEN 1904..1906; /note="LWG->AAA: Impairs interaction with the CCR4-NOT complex, no effect on interaction with PABPC1; when associated with 1647-A-A-1895.
uniprot
proteins
protein_family
GW182 family
uniprot
proteins
pubmed
10997877
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19304925
uniprot
proteins
pubmed
19383768
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19716330
uniprot
proteins
pubmed
21981923
uniprot
proteins
pubmed
21984184
uniprot
proteins
pubmed
21984185
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
1936
uniprot
proteins