SLC16A8
entrez
23539
canonical
uniprot
O95907
canonical
ensembl
ENSG00000100156
resolver
ensp
ENSP00000321735
resolver
ensp
ENSP00000506669
resolver
ensp
ENSP00000572639
resolver
enst
ENST00000320521
resolver
enst
ENST00000681075
resolver
enst
ENST00000902580
resolver
genesymbol
SLC16A8
resolver
genesymbol_syn
MCT3
resolver
hgnc
HGNC:16270
resolver
uniprot
Q9UBE2
resolver
uniprot_entry
MOT3_HUMAN
resolver
uniprot_sec
Q9UBE2
resolver
amino_acid_sequence
MGAGGPRRGEGPPDGGWGWVVLGACFVVTGFAYGFPKAVSVFFRALMRDFDAGYSDTAWVSSIMLAMLYGTGPVSSILVTRFGCRPVMLAGGLLASAGMILASFATRLLELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSALSPLGQQLLERFGWRGGFLLLGGLLLHCCACGAVMRPPPGPGPRPRRDSAGDRAGDAPGEAEADGAGLQLREASPRVRPRRRLLDLAVCTDRAFAVYAVTKFLMALGLFVPAILLVNYAKDAGVPDTDAAFLLSIVGFVDIVARPACGALAGLARLRPHVPYLFSLALLANGLTDLSSARARSYGALVAFCVAFGLSYGMVGALQFEVLMAAVGAPRFPSALGLVLLVEAAAVLIGPPSAGRLVDVLKNYEIIFYLAGSEVALAGVFMAVATNCCLRCAKAAPSGPGTEGGASDTEDAEAEGDSEPLPVVAEEPGNLEALEVLSARGEPTEPEIEARPRLAAESV
uniprot
proteins
function
FUNCTION: Probable retinal pigment epithelium (RPE)-specific proton-coupled L-lactate transporter (By similarity). May facilitate transport of lactate and H(+) out of the retina and could therefore play a role in pH and ion homeostasis of the outer retina (By similarity). {ECO:0000250|UniProtKB:O35308, ECO:0000250|UniProtKB:Q90632}.
uniprot
proteins
mass_dalton
52319
uniprot
proteins
mutagenesis
MUTAGEN 465..469; /note="Missing: Affects subcellular localization leading to apical localization."; /evidence="ECO:0000269|PubMed:21199217"; MUTAGEN 471; /note="E->A: Abolishes basolateral membrane localization; when associated with A-472."; /evidence="ECO:0000269|PubMed:21199217"; MUTAGEN 472; /note="E->A: Abolishes basolateral membrane localization; when associated with A-471."; /evidence="ECO:0000269|PubMed:21199217"; MUTAGEN 481; /note="V->A: Affects subcellular localization leading to apical localization; when associated with A-482."; /evidence="ECO:0000269|PubMed:21199217"; MUTAGEN 482; /note="L->A: Affects subcellular localization leading to apical localization; when associated with A-481."; /evidence="ECO:0000269|PubMed:21199217
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Monocarboxylate porter (TC 2.A.1.13) family
uniprot
proteins
pubmed
10493836
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
21199217
uniprot
proteins
sequence_length
504
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:21199217}; Multi-pass membrane protein {ECO:0000255}. Note=Basolateral sorting signals (BLSS) in C-terminal cytoplasmic tail ensure its basolateral expression (PubMed:21199217). Colocalizes with BSG in basolateral cell membrane of the retinal pigment epithelium (By similarity). {ECO:0000250|UniProtKB:O35308, ECO:0000269|PubMed:21199217}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..35; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 59..79; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 86..106; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 116..136; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 144..164; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 173..193; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 255..275; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 290..310; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 319..335; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 343..363; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 377..397; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 411..431; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins