Traf1
entrez
22029
canonical
uniprot
P39428
canonical
ensembl
ENSMUSG00000026875
resolver
ensp
ENSMUSP00000028234
resolver
ensp
ENSMUSP00000108687
resolver
ensp
ENSMUSP00000130759
resolver
ensp
ENSMUSP00000284239
resolver
enst
ENSMUST00000028234
resolver
enst
ENSMUST00000113064
resolver
enst
ENSMUST00000172159
resolver
genesymbol
Traf1
resolver
uniprot
Q8CE28
resolver
uniprot_entry
TRAF1_MOUSE
resolver
uniprot_sec
Q8CE28
resolver
amino_acid_sequence
MASSSAPDENEFQFGCPPAPCQDPSEPRVLCCTACLSENLRDDEDRICPKCRADNLHPVSPGSPLTQEKVHSDVAEAEIMCPFAGVGCSFKGSPQSMQEHEATSQSSHLYLLLAVLKEWKSSPGSNLGSAPMALERNLSELQLQAAVEATGDLEVDCYRAPCCESQEELALQHLVKEKLLAQLEEKLRVFANIVAVLNKEVEASHLALAASIHQSQLDREHILSLEQRVVELQQTLAQKDQVLGKLEHSLRLMEEASFDGTFLWKITNVTKRCHESVCGRTVSLFSPAFYTAKYGYKLCLRLYLNGDGSGKKTHLSLFIVIMRGEYDALLPWPFRNKVTFMLLDQNNREHAIDAFRPDLSSASFQRPQSETNVASGCPLFFPLSKLQSPKHAYVKDDTMFLKCIVDTSA
uniprot
proteins
function
FUNCTION: Adapter molecule that is involved in multiple signaling pathways including the NF-kappa-B and MAPK pathways and thus influences inflammatory and apoptotic responses (PubMed:26860405). Plays a critical role in regulating T-cell activation both through restricting the costimulation-independent activation of NIK in activated T-cells and by promoting the TNFRSF9-induced classical NF-kappa-B pathway (PubMed:22570473, PubMed:23376065). Forms a heterotrimer with TRAF2 as part of an E3 ubiquitin-protein ligase complex that mediates ubiquitination of target proteins such as MAP3K14 and gasdermin D/GSDMD (By similarity). This complex also recruits the antiapoptotic E3 ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2. Acts downstream of MAVS within the RIG-I/MAVS antiviral pathway to enhance type I interferon signaling (By similarity). Regulates osteoclastogenesis by preventing ubiquitination and degradation of MLST8, thereby promoting PI3K-AKT signaling and enhancing oxidative phosphorylation in osteoclasts (PubMed:39863932). {ECO:0000250|UniProtKB:Q13077, ECO:0000269|PubMed:11672546, ECO:0000269|PubMed:18429822, ECO:0000269|PubMed:22570473, ECO:0000269|PubMed:23376065, ECO:0000269|PubMed:26860405, ECO:0000269|PubMed:39863932}.
uniprot
proteins
mass_dalton
45465
uniprot
proteins
mutagenesis
MUTAGEN 139; /note="S->A: Loss of phosphorylation site. Reduces global phosphorylation."; /evidence="ECO:0000269|PubMed:18429822, ECO:0000269|PubMed:23376065"; MUTAGEN 139; /note="S->D: Strong loss of TBK1 association."; /evidence="ECO:0000269|PubMed:23376065"; MUTAGEN 264; /note="W->A: Decreased interaction with FBXL2."; /evidence="ECO:0000269|PubMed:23542741
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated by BIRC2 and/or BIRC3, leading to its subsequent proteasomal degradation (By similarity). Ubiquitinated by the SCF(FBXL2) complex, leading to its degradation by the proteasome (PubMed:23542741). {ECO:0000250|UniProtKB:Q13077, ECO:0000269|PubMed:23542741}.
uniprot
proteins
pubmed
11672546
uniprot
proteins
pubmed
11804591
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16352630
uniprot
proteins
pubmed
18429822
uniprot
proteins
pubmed
18849341
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22424771
uniprot
proteins
pubmed
22570473
uniprot
proteins
pubmed
23376065
uniprot
proteins
pubmed
23542741
uniprot
proteins
pubmed
26860405
uniprot
proteins
pubmed
39863932
uniprot
proteins
pubmed
8069916
uniprot
proteins
pubmed
9104814
uniprot
proteins
sequence_length
409
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins