Brsk1
entrez
499073
canonical
uniprot
B2DD29
canonical
ensembl
ENSRNOG00000017673
resolver
ensembl
ENSRNOG00055014409
resolver
ensembl
ENSRNOG00060026686
resolver
ensembl
ENSRNOG00065032331
resolver
ensp
ENSRNOP00000087514
resolver
ensp
ENSRNOP00055020269
resolver
ensp
ENSRNOP00060038644
resolver
ensp
ENSRNOP00065045884
resolver
enst
ENSRNOT00000097053
resolver
enst
ENSRNOT00055024792
resolver
enst
ENSRNOT00060046487
resolver
enst
ENSRNOT00065055718
resolver
genesymbol
Brsk1
resolver
genesymbol_syn
Sadb
resolver
uniprot
F1M6Y8
resolver
uniprot_entry
BRSK1_RAT
resolver
uniprot_sec
F1M6Y8
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation on Thr-189 by STK11/LKB1.
uniprot
proteins
amino_acid_sequence
MSSGSKEGGGGSPAYHLPHPHPHPPQHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAVKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDSPMLSRHGKRRPERKSMEVLSITDAGSGGSPVPTRRALEMAQHSQRSRSVSGASTGLSSSPLSSPRSPVFSFSPEPGVGDEARGGGSPTSKTQTLPSRGPRGGGAGEQPPPPSARSTPLPGPPGSPRSSGGTPLHSPLHTPRASPTGTPGTTPPPSPGGGVGGAAWRSRLNSIRNSFLGSPRFHRRKMQVPTAEEMSSLTPESSPELAKRSWFGNFISLDKEEQIFLVLKDKPLSSIKADIVHAFLSIPSLSHSVLSQTSFRAEYKASGGPSVFQKPVRFQVDISSSEGPEPSPRRDGSSGGGIYSVTFTLISGPSRRFKRVVETIQAQLLSTHDQPSVQALADEKNGAQTRPAGTPPRSLQPPPGRPDPDLSSSPRRGPSKDKKLLATNGTPLP
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
ec_number
2.7.11.26
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-523' and 'Ser-573'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C (By similarity). In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. {ECO:0000250, ECO:0000269|PubMed:16630837}.
uniprot
proteins
mass_dalton
85183
uniprot
proteins
mutagenesis
MUTAGEN 63; /note="K->R: Abolishes kinase activity."; /evidence="ECO:0000269|PubMed:16630837"; MUTAGEN 189; /note="T->A: Decreased autophosphorylation; when associated with A-193."; /evidence="ECO:0000269|PubMed:16630837"; MUTAGEN 193; /note="S->A: Decreased autophosphorylation; when associated with A-189."; /evidence="ECO:0000269|PubMed:16630837
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Thr-189 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Not phosphorylated at Thr-189 by CaMKK2. In contrast, it is phosphorylated and activated by CaMKK1. May be inactivated via dephosphorylation of Thr-189 by PP2C. May be autophosphorylated. {ECO:0000269|PubMed:18324781}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
SNF1 subfamily
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
16630837
uniprot
proteins
pubmed
18324781
uniprot
proteins
pubmed
18794346
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
778
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Synapse {ECO:0000269|PubMed:16630837}. Presynaptic active zone {ECO:0000269|PubMed:16630837}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000269|PubMed:16630837}. Note=Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS-induced DNA damage (By similarity). {ECO:0000250}.
uniprot
proteins