COMMD3
entrez
23412
canonical
uniprot
Q9UBI1
canonical
ensembl
ENSG00000148444
resolver
ensp
ENSP00000366032
resolver
ensp
ENSP00000530517
resolver
enst
ENST00000376836
resolver
enst
ENST00000860458
resolver
genesymbol
COMMD3
resolver
genesymbol_syn
BUP
resolver
genesymbol_syn
C10orf8
resolver
hgnc
HGNC:23332
resolver
uniprot
D3DRU7
resolver
uniprot
Q5T8Y9
resolver
uniprot_entry
COMD3_HUMAN
resolver
uniprot_sec
D3DRU7
resolver
uniprot_sec
Q5T8Y9
resolver
amino_acid_sequence
MELSESVQKGFQMLADPRSFDSNAFTLLLRAAFQSLLDAQADEAVLDHPDLKHIDPVVLKHCHAAAATYILEAGKHRADKSTLSTYLEDCKFDRERIELFCTEYQNNKNSLEILLGSIGRSLPHITDVSWRLEYQIKTNQLHRMYRPAYLVTLSVQNTDSPSYPEISFSCSMEQLQDLVGKLKDASKSLERATQL
uniprot
proteins
function
FUNCTION: Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). Modulates Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits (PubMed:23637203). {ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:23637203, ECO:0000269|PubMed:37172566, ECO:0000269|PubMed:38459129, ECO:0000305|PubMed:21778237}.
uniprot
proteins
mass_dalton
22151
uniprot
proteins
protein_family
COMM domain-containing protein 3 family
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15799966
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21778237
uniprot
proteins
pubmed
23563313
uniprot
proteins
pubmed
23637203
uniprot
proteins
pubmed
25355947
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
37172566
uniprot
proteins
pubmed
38459129
uniprot
proteins
pubmed
38504028
uniprot
proteins
sequence_length
195
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21778237}. Nucleus {ECO:0000269|PubMed:21778237}.
uniprot
proteins