LEPROT
entrez
54741
canonical
uniprot
O15243
canonical
ensembl
ENSG00000213625
resolver
ensp
ENSP00000360104
resolver
ensp
ENSP00000483521
resolver
enst
ENST00000371065
resolver
enst
ENST00000613538
resolver
genesymbol
LEPROT
resolver
genesymbol_syn
LEPR
resolver
genesymbol_syn
OBR
resolver
hgnc
HGNC:29477
resolver
uniprot
A0A087X0N2
resolver
uniprot
Q6FHL5
resolver
uniprot_entry
A0A087X0N2_HUMAN
resolver
uniprot_entry
OBRG_HUMAN
resolver
uniprot_sec
Q6FHL5
resolver
amino_acid_sequence
MAGVKALVALSFSGAIGLTFLMLGCALEDYGVYWPLFVLIFHAISPIPHFIAKRVTYDSDATSSACRELAYFFTTGIVVSAFGFPVILARVAVIKWGACGLVLAGNAVIFLTIQGFFLIFGRGDDFSWEQW
uniprot
proteins
function
FUNCTION: Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. {ECO:0000269|PubMed:18042720, ECO:0000269|PubMed:19907080}.
uniprot
proteins
mass_dalton
14254
uniprot
proteins
protein_family
OB-RGRP/VPS55 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18042720
uniprot
proteins
pubmed
19907080
uniprot
proteins
pubmed
9207021
uniprot
proteins
sequence_length
131
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..27; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 32..52; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 69..89; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 100..120; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins