Abi1
entrez
11308
canonical
uniprot
Q8CBW3
canonical
ensembl
ENSMUSG00000058835
resolver
ensp
ENSMUSP00000077997
resolver
ensp
ENSMUSP00000088957
resolver
ensp
ENSMUSP00000090860
resolver
ensp
ENSMUSP00000110191
resolver
ensp
ENSMUSP00000116093
resolver
ensp
ENSMUSP00000117335
resolver
ensp
ENSMUSP00000118491
resolver
ensp
ENSMUSP00000120462
resolver
ensp
ENSMUSP00000120621
resolver
ensp
ENSMUSP00000120769
resolver
ensp
ENSMUSP00000245389
resolver
ensp
ENSMUSP00000245390
resolver
ensp
ENSMUSP00000245392
resolver
ensp
ENSMUSP00000245397
resolver
ensp
ENSMUSP00000245404
resolver
ensp
ENSMUSP00000245407
resolver
ensp
ENSMUSP00000245408
resolver
ensp
ENSMUSP00000245415
resolver
ensp
ENSMUSP00000245422
resolver
ensp
ENSMUSP00000245426
resolver
ensp
ENSMUSP00000344539
resolver
enst
ENSMUST00000078977
resolver
enst
ENSMUST00000091394
resolver
enst
ENSMUST00000093171
resolver
enst
ENSMUST00000139038
resolver
enst
ENSMUST00000153931
resolver
genesymbol
Abi1
resolver
genesymbol_syn
Ssh3bp1
resolver
uniprot
B7ZCU0
resolver
uniprot
B7ZCU2
resolver
uniprot
B7ZCU3
resolver
uniprot
B7ZCU4
resolver
uniprot
B7ZCU5
resolver
uniprot
Q3TJ64
resolver
uniprot
Q3TJR5
resolver
uniprot
Q3TPY5
resolver
uniprot
Q3U8V0
resolver
uniprot
Q60747
resolver
uniprot
Q91ZM5
resolver
uniprot
Q923I9
resolver
uniprot
Q99KH4
resolver
uniprot_entry
ABI1_MOUSE
resolver
uniprot_entry
B7ZCU0_MOUSE
resolver
uniprot_entry
B7ZCU2_MOUSE
resolver
uniprot_entry
B7ZCU3_MOUSE
resolver
uniprot_entry
B7ZCU4_MOUSE
resolver
uniprot_entry
B7ZCU5_MOUSE
resolver
uniprot_entry
Q3TJ64_MOUSE
resolver
uniprot_entry
Q3TJR5_MOUSE
resolver
uniprot_entry
Q3TPY5_MOUSE
resolver
uniprot_sec
Q3U8V0
resolver
uniprot_sec
Q60747
resolver
uniprot_sec
Q91ZM5
resolver
uniprot_sec
Q923I9
resolver
uniprot_sec
Q99KH4
resolver
amino_acid_sequence
MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLASVAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQKPPSPPVSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTAGPAAPGAAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVAAQFSAQPHVNGGPLYSQNSISVAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYSDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFKEGAIIYVIKKNDDGWFEGVCNRVTGLFPGNYVESIMHYTD
uniprot
proteins
function
FUNCTION: May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. In vitro, at least isoform 2 and isoform 4 suppress the transforming activity of Abelson murine leukemia virus (v-Abl) after overexpression in fibroblasts. May play a role in regulation EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:10499589, ECO:0000269|PubMed:11526477, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15143189, ECO:0000269|PubMed:15558031, ECO:0000269|PubMed:7590237}.
uniprot
proteins
mass_dalton
52288
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues after serum stimulation or induction by v-Abl. Seems to be phosphorylated at Tyr-53 by ABL1, required for nuclear but not for synaptic localization (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
ABI family
uniprot
proteins
pubmed
10499589
uniprot
proteins
pubmed
10995551
uniprot
proteins
pubmed
11477655
uniprot
proteins
pubmed
11516653
uniprot
proteins
pubmed
11526477
uniprot
proteins
pubmed
12672821
uniprot
proteins
pubmed
14765121
uniprot
proteins
pubmed
15143189
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15558031
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7590237
uniprot
proteins
sequence_length
481
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Postsynaptic density {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localized to protruding lamellipodia and filopodia tips. Also localized to neuronal growth cones and synaptosomes. May shuttle from the postsynaptic densities to the nucleus (By similarity). {ECO:0000250}.
uniprot
proteins