Ramp3
entrez
56089
canonical
uniprot
Q9WUP1
canonical
ensembl
ENSMUSG00000041046
resolver
ensp
ENSMUSP00000047518
resolver
enst
ENSMUST00000045374
resolver
genesymbol
Ramp3
resolver
uniprot
Q5SWP4
resolver
uniprot_entry
RAMP3_MOUSE
resolver
uniprot_sec
Q5SWP4
resolver
amino_acid_sequence
MKTPAQRLHLLPLLLLLCGECAQVCGCNETGMLERLPRCGKAFADMMQKVAVWKWCNLSEFIVYYESFTNCTEMETNIMGCYWPNPLAQSFITGIHRQFFSNCTVDRTHWEDPPDEVLIPLIAVPVVLTVAMAGLVVWRSKHTDRLL
uniprot
proteins
function
FUNCTION: Accessory protein that interacts with and modulates the function of G protein-coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL), calcitonin receptor (CALCR) and G protein-coupled estrogen receptor 1 (GPER1) (PubMed:10854696, PubMed:23674134). Required for the transport of CALCRL and GPER1 receptors to the plasma membrane (By similarity). Plays a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a GPER1-dependent manner (PubMed:23674134). Together with CALCRL, form a receptor complex for adrenomedullin/ADM and intermedin/ADM2 (PubMed:10854696). Together with CALCR, act as a receptor complex for amylin/IAPP (By similarity). {ECO:0000250|UniProtKB:O60896, ECO:0000269|PubMed:10854696, ECO:0000269|PubMed:23674134}.
uniprot
proteins
mass_dalton
16779
uniprot
proteins
protein_family
RAMP family
uniprot
proteins
pubmed
10777702
uniprot
proteins
pubmed
10854696
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23674134
uniprot
proteins
sequence_length
147
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23674134}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O60896}. Membrane {ECO:0000250|UniProtKB:O60896}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O60896}. Note=Moves from intracellular puncta to the plasma membrane in a RAMP3-dependent manner. {ECO:0000250|UniProtKB:O60896}.
uniprot
proteins
transmembrane_region
TRANSMEM 113..137; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O60896
uniprot
proteins