Serpina12
entrez
68054
canonical
uniprot
Q7TMF5
canonical
ensembl
ENSMUSG00000041567
resolver
ensp
ENSMUSP00000045572
resolver
enst
ENSMUST00000043915
resolver
genesymbol
Serpina12
resolver
uniprot
Q9CQ32
resolver
uniprot_entry
SPA12_MOUSE
resolver
uniprot_sec
Q9CQ32
resolver
activity_regulation
ACTIVITY REGULATION: Inhibition of KLK7 is enhanced by heparin. {ECO:0000250|UniProtKB:Q8IW75}.
uniprot
proteins
amino_acid_sequence
MTRMLDLGLFLAGLLTVKGLLQDRDAPDMYDSPVRVQEWRGKKDARQLARHNMEFGFKLLQRLASNSPQGNIFLSPLSISTAFSMLSLGAQNSTLEEIREGFNFKEMSNWDVHAAFHYLLHKLNQETEDTKMNLGNALFMDQKLRPQQRFLNLAKNVYDADMVLTNFQDLENTQKDINRYISQKTHSRIKNMVKSIDPGTVMILTNYIYFRGRWQYEFDPKQTKEEEFFIEKGKTVKVPMMFQRGLYDMAYDSQLSCTILEIPYRGNITATFVLPDNGKLKLLEQGLQADIFAKWKSLLSKRVVDVWVPKLRISSTYNMKKVLSRLGISKIFEENGDLTRISSHRSLKVGEAVHKAELKMDEKGMEGAAGSGAQTLPMETPRHMKLDRPFLMMIYENFMPSMVFLARIYDPSG
uniprot
proteins
function
FUNCTION: Adipokine that modulates insulin action by specifically inhibiting its target protease KLK7 in white adipose tissues. {ECO:0000269|PubMed:16030142, ECO:0000269|PubMed:23370777}.
uniprot
proteins
mass_dalton
47634
uniprot
proteins
post_translational_modification
PTM: Glycosylation slightly decreases affinity for heparin, but otherwise has no significant effect on KLK7 inhibitory activity or thermal stability of the protein. {ECO:0000250|UniProtKB:Q8IW75}.
uniprot
proteins
protein_family
Serpin family
uniprot
proteins
pubmed
16030142
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23370777
uniprot
proteins
sequence_length
413
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23370777}.
uniprot
proteins