Srebf2
entrez
300095
canonical
uniprot
Q3T1I5
canonical
ensembl
ENSRNOG00000007400
resolver
ensembl
ENSRNOG00055029130
resolver
ensembl
ENSRNOG00060031189
resolver
ensembl
ENSRNOG00065030467
resolver
ensp
ENSRNOP00000052893
resolver
ensp
ENSRNOP00055041542
resolver
ensp
ENSRNOP00060044909
resolver
ensp
ENSRNOP00065043173
resolver
enst
ENSRNOT00000056041
resolver
enst
ENSRNOT00055050458
resolver
enst
ENSRNOT00060054150
resolver
enst
ENSRNOT00065052534
resolver
genesymbol
Srebf2
resolver
uniprot
F1MA23
resolver
uniprot_entry
F1MA23_RAT
resolver
uniprot_entry
SRBP2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activation by cleavage is down-regulated upon activation of SIRT3-dependent PRKAA1/AMPK-alpha signaling cascade which leads to inhibition of ATP-consuming lipogenesis to restore cellular energy balance. {ECO:0000250|UniProtKB:Q3U1N2}.
uniprot
proteins
amino_acid_sequence
MDENSELGGLETMETLTELGDELTLGDIDEMLQFVSNQVGEFSDLFSEQLCSSFPGGGGGSGSGGTSNNSSGRGTSGGAADPAVQRSFSQVPLSTFSPSSTSPQAPALQVKVSPTPPRATPVLQPRPQPQPQPPAQLQQQTVMITPTFSTAPQTRIIQQPLIYQNAATSFQVLQPQVQSLVTSSQVQPVTIQQQVQTVQAQRVLTQTANGTLQTLAPATVQTVATPQVQQVPVLVQPQIIKTDSLVLTTLKTDGSPVMAAVQNPALTALTAPIQTAALQVPTLVGSNGAILTTMPVMMGQEKVPIKQVPGGVKQLEPPKEGERRTTHNIIEKRYRSSINDKIIELKDLVMGTDAKMHKSGVLRKAIDYIKYLQQVNHKLRQENMVLKLANQKNKLLKGIDLGSLVDSDVDLKIDDFNQNVLLMSPPASDSGSQAGFSPYSIDSEPGSPLLDDAKVKDEPDSPPVALGMVDRSRILLCVLTFLGLSFNPLTSLLQWGGAHNPDQHPYSGSGRNVLSLESGSGGWFDWMMPTLLLWLLNGVIVLSVFVKLLVHGEPVIRPHSRSSVTFWRHRKQADLDLAKGDFAAAAANLQTCLSVLGRALPTSRLDLACSLSWNVIRYSLQKLRLVRWLLKKVFQRWRATPATAAGFEDEAKSSARDAALAYHRLHQLHITGKLPAGSACSDVHMALCAVNLAECAEEKIPPSTLVEIHLTAAMGLKTRCGGKLGFLASYFLNRAQSLCGPEHSAVPDSLRWLCHPLGQKFFMERSWSIKSAAKDSLYCAQRNPADPIAQVHQAFCKHLLERAVEALVKPQAKKKAGDREEESCEFSSALEFLKLLHSFVDSVGFVASPFSSSSVLRSALGPDVVCRWWTSAITVAISWLQGDDAAVRSHFTEVERVPKALEVTESPLVKAVFYACRAMHASLSGKADGQQNSFCHCERASGHLWSSLNVSGTTSDPSLNHVVQLLTCDLLLSLRTTLWQKQASASQLLGETYHASGTELAGFQRDLGSLRRLAHSFRPAYRKVFLHEATVRLMAGASPTRTHQLLEHSLRRRTTQNTKHGEVDTWPGQRERATAILLACRHLPLSFLSSPGQRAVLLAEAARTLEKVGDRRSCSDCQQMIVKLGGGTAIAAS
uniprot
proteins
function
FUNCTION: [Sterol regulatory element-binding protein 2]: Precursor of the transcription factor form (Processed sterol regulatory element-binding protein 2), which is embedded in the endoplasmic reticulum membrane. Low sterol concentrations promote processing of this form, releasing the transcription factor form that translocates into the nucleus and activates transcription of genes involved in cholesterol biosynthesis. {ECO:0000250|UniProtKB:Q12772}.; FUNCTION: [Processed sterol regulatory element-binding protein 2]: Key transcription factor that regulates expression of genes involved in cholesterol biosynthesis. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Regulates transcription of genes related to cholesterol synthesis pathway. Regulates hepatic lipogenesis. {ECO:0000250|UniProtKB:Q12772}.
uniprot
proteins
mass_dalton
122976
uniprot
proteins
post_translational_modification
PTM: [Sterol regulatory element-binding protein 2]: Processed in the Golgi apparatus, releasing the protein from the membrane. At low cholesterol the SCAP-SREBP complex is recruited into COPII vesicles for export from the endoplasmic reticulum. In the Golgi, complex SREBPs are cleaved sequentially by site-1 (MBTPS1, S1P) and site-2 (MBTPS2, S2P) proteases. The first cleavage by site-1 protease occurs within the luminal loop, the second cleavage by site-2 protease occurs within the first transmembrane domain, releasing the transcription factor from the Golgi membrane. Apoptosis triggers cleavage by the cysteine proteases caspase-3 and caspase-7. Cleavage and activation is induced by mediated cholesterol efflux. {ECO:0000250|UniProtKB:Q12772}.; PTM: Phosphorylated by AMPK, leading to suppress protein processing and nuclear translocation, and repress target gene expression. {ECO:0000250|UniProtKB:Q3U1N2}.; PTM: [Sterol regulatory element-binding protein 2]: SCAP-free SREBF2 is ubiquitinated by the BCR(ARMC5) complex, leading to its degradation. {ECO:0000250|UniProtKB:Q12772}.; PTM: [Processed sterol regulatory element-binding protein 2]: Ubiquitinated; the nuclear form has a rapid turnover and is rapidly ubiquitinated and degraded by the proteasome in the nucleus. {ECO:0000250|UniProtKB:Q12772}.
uniprot
proteins
protein_family
SREBP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
1133
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Sterol regulatory element-binding protein 2]: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q12772}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q12772}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250|UniProtKB:Q12772}; Multi-pass membrane protein {ECO:0000255}. Note=At high sterol concentrations, the SCAP-SREBP is retained in the endoplasmic reticulum. Low sterol concentrations promote recruitment into COPII-coated vesicles and transport of the SCAP-SREBP to the Golgi, where it is processed. {ECO:0000250|UniProtKB:Q12772}.; SUBCELLULAR LOCATION: [Processed sterol regulatory element-binding protein 2]: Nucleus {ECO:0000250|UniProtKB:Q12772}. Note=Transported into the nucleus with the help of importin-beta. Dimerization of the bHLH domain is a prerequisite for importin beta-dependent nuclear import. {ECO:0000250|UniProtKB:Q3U1N2}.
uniprot
proteins
transmembrane_region
TRANSMEM 474..494; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 526..546; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins