TLR5
entrez
7100
canonical
uniprot
O60602
canonical
ensembl
ENSG00000187554
resolver
ensp
ENSP00000385458
resolver
ensp
ENSP00000493892
resolver
ensp
ENSP00000496355
resolver
ensp
ENSP00000519509
resolver
ensp
ENSP00000519510
resolver
ensp
ENSP00000530876
resolver
ensp
ENSP00000530877
resolver
ensp
ENSP00000530878
resolver
ensp
ENSP00000530879
resolver
ensp
ENSP00000530880
resolver
ensp
ENSP00000530881
resolver
ensp
ENSP00000530882
resolver
ensp
ENSP00000581325
resolver
ensp
ENSP00000634810
resolver
ensp
ENSP00000634811
resolver
ensp
ENSP00000634812
resolver
ensp
ENSP00000634813
resolver
ensp
ENSP00000634814
resolver
ensp
ENSP00000634815
resolver
ensp
ENSP00000634816
resolver
enst
ENST00000407096
resolver
enst
ENST00000484766
resolver
enst
ENST00000642603
resolver
enst
ENST00000645434
resolver
enst
ENST00000714229
resolver
enst
ENST00000860817
resolver
enst
ENST00000860818
resolver
enst
ENST00000860819
resolver
enst
ENST00000860820
resolver
enst
ENST00000860821
resolver
enst
ENST00000860822
resolver
enst
ENST00000860823
resolver
enst
ENST00000911266
resolver
enst
ENST00000964751
resolver
enst
ENST00000964752
resolver
enst
ENST00000964753
resolver
enst
ENST00000964754
resolver
enst
ENST00000964755
resolver
enst
ENST00000964756
resolver
enst
ENST00000964757
resolver
genesymbol
TLR5
resolver
genesymbol_syn
TIL3
resolver
hgnc
HGNC:11851
resolver
uniprot
A0A2R8Y7Z4
resolver
uniprot
B1AZ05
resolver
uniprot
B3Y633
resolver
uniprot
B9VJ63
resolver
uniprot
D1CS80
resolver
uniprot
D3DTB8
resolver
uniprot
O15456
resolver
uniprot
Q32MI2
resolver
uniprot
Q32MI3
resolver
uniprot_entry
A0A2R8Y7Z4_HUMAN
resolver
uniprot_entry
TLR5_HUMAN
resolver
uniprot_sec
B1AZ05
resolver
uniprot_sec
B3Y633
resolver
uniprot_sec
B9VJ63
resolver
uniprot_sec
D1CS80
resolver
uniprot_sec
D3DTB8
resolver
uniprot_sec
O15456
resolver
uniprot_sec
Q32MI2
resolver
uniprot_sec
Q32MI3
resolver
amino_acid_sequence
MGDHLDLLLGVVLMAGPVFGIPSCSFDGRIAFYRFCNLTQVPQVLNTTERLLLSFNYIRTVTASSFPFLEQLQLLELGSQYTPLTIDKEAFRNLPNLRILDLGSSKIYFLHPDAFQGLFHLFELRLYFCGLSDAVLKDGYFRNLKALTRLDLSKNQIRSLYLHPSFGKLNSLKSIDFSSNQIFLVCEHELEPLQGKTLSFFSLAANSLYSRVSVDWGKCMNPFRNMVLEILDVSGNGWTVDITGNFSNAISKSQAFSLILAHHIMGAGFGFHNIKDPDQNTFAGLARSSVRHLDLSHGFVFSLNSRVFETLKDLKVLNLAYNKINKIADEAFYGLDNLQVLNLSYNLLGELYSSNFYGLPKVAYIDLQKNHIAIIQDQTFKFLEKLQTLDLRDNALTTIHFIPSIPDIFLSGNKLVTLPKINLTANLIHLSENRLENLDILYFLLRVPHLQILILNQNRFSSCSGDQTPSENPSLEQLFLGENMLQLAWETELCWDVFEGLSHLQVLYLNHNYLNSLPPGVFSHLTALRGLSLNSNRLTVLSHNDLPANLEILDISRNQLLAPNPDVFVSLSVLDITHNKFICECELSTFINWLNHTNVTIAGPPADIYCVYPDSFSGVSLFSLSTEGCDEEEVLKSLKFSLFIVCTVTLTLFLMTILTVTKFRGFCFICYKTAQRLVFKDHPQGTEPDMYKYDAYLCFSSKDFTWVQNALLKHLDTQYSDQNRFNLCFEERDFVPGENRIANIQDAIWNSRKIVCLVSRHFLRDGWCLEAFSYAQGRCLSDLNSALIMVVVGSLSQYQLMKHQSIRGFVQKQQYLRWPEDLQDVGWFLHKLSQQILKKEKEKKKDNNIPLQTVATIS
uniprot
proteins
disease_involvement
DISEASE: Systemic lupus erythematosus 1 (SLEB1) [MIM:601744]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response (PubMed:11323673, PubMed:18490781). Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota (PubMed:29934223). Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response (PubMed:11489966, PubMed:20855887). Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life (By similarity). {ECO:0000250|UniProtKB:Q9JLF7, ECO:0000269|PubMed:11323673, ECO:0000269|PubMed:11489966, ECO:0000269|PubMed:18490781, ECO:0000269|PubMed:20855887, ECO:0000269|PubMed:29934223}.
uniprot
proteins
mass_dalton
97800
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-805 by PKD/PRKD1; phosphorylation induces the production of inflammatory cytokines. {ECO:0000269|PubMed:17157808, ECO:0000269|PubMed:17442957}.; PTM: Phosphorylated at Tyr-798 upon flagellin binding; required for signaling. {ECO:0000269|PubMed:17157808, ECO:0000269|PubMed:17442957}.
uniprot
proteins
protein_family
Toll-like receptor family
uniprot
proteins
pubmed
11323673
uniprot
proteins
pubmed
11489966
uniprot
proteins
pubmed
14623910
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16027372
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17157808
uniprot
proteins
pubmed
17442957
uniprot
proteins
pubmed
18490781
uniprot
proteins
pubmed
18810425
uniprot
proteins
pubmed
19179655
uniprot
proteins
pubmed
19924287
uniprot
proteins
pubmed
20855887
uniprot
proteins
pubmed
22173220
uniprot
proteins
pubmed
23447684
uniprot
proteins
pubmed
24778236
uniprot
proteins
pubmed
29934223
uniprot
proteins
pubmed
9435236
uniprot
proteins
pubmed
9596645
uniprot
proteins
sequence_length
858
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24778236}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 640..660; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins