NOL12
entrez
79159
canonical
uniprot
Q9UGY1
canonical
ensembl
ENSG00000273899
resolver
ensp
ENSP00000352021
resolver
ensp
ENSP00000403059
resolver
ensp
ENSP00000482349
resolver
enst
ENST00000359114
resolver
enst
ENST00000438329
resolver
enst
ENST00000611699
resolver
genesymbol
NOL12
resolver
hgnc
HGNC:28585
resolver
uniprot_entry
NOL12_HUMAN
resolver
amino_acid_sequence
MGRNKKKKRDGDDRRPRLVLSFDEEKRREYLTGFHKRKVERKKAAIEEIKQRLKEEQRKLREERHQEYLKMLAEREEALEEADELDRLVTAKTESVQYDHPNHTVTVTTISDLDLSGARLLGLTPPEGGAGDRSEEEASSTEKPTKALPRKSRDPLLSQRISSLTASLHAHSRKKVKRKHPRRAQDSKKPPRAPRTSKAQRRRLTGKARHSGE
uniprot
proteins
function
FUNCTION: Multifunctional RNA binding protein that plays a role in RNA metabolism and DNA maintenance. Participates in the resolution of DNA stress and the maintenance of genome integrity by localizing to sites of DNA insults (PubMed:29069457). Also plays a role in proper nucleolar organization by limiting nucleolar size and regulating nucleolar number. Mechanistically, regulates the nucleolar levels of fibrillarin and nucleolin, two key players in pre-rRNA processing and ribosome assembly (PubMed:30988155). {ECO:0000269|PubMed:29069457, ECO:0000269|PubMed:30988155}.
uniprot
proteins
mass_dalton
24663
uniprot
proteins
mutagenesis
MUTAGEN 21; /note="S->A: Loss of DNA damage response pathway activation."; /evidence="ECO:0000269|PubMed:29069457"; MUTAGEN 23; /note="D->L: Loss of DNA damage response pathway activation."; /evidence="ECO:0000269|PubMed:29069457
uniprot
proteins
protein_family
RRP17 family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
12529303
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21153684
uniprot
proteins
pubmed
29069457
uniprot
proteins
pubmed
30988155
uniprot
proteins
sequence_length
213
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:29069457, ECO:0000269|PubMed:30988155}. Nucleus {ECO:0000269|PubMed:29069457}. Cytoplasm {ECO:0000269|PubMed:29069457}.
uniprot
proteins