FBXO40
entrez
51725
canonical
uniprot
Q9UH90
canonical
ensembl
ENSG00000163833
resolver
ensp
ENSP00000337510
resolver
ensp
ENSP00000538867
resolver
ensp
ENSP00000538868
resolver
ensp
ENSP00000538869
resolver
ensp
ENSP00000538870
resolver
ensp
ENSP00000638477
resolver
ensp
ENSP00000638478
resolver
ensp
ENSP00000638479
resolver
ensp
ENSP00000638480
resolver
ensp
ENSP00000638481
resolver
enst
ENST00000338040
resolver
enst
ENST00000868808
resolver
enst
ENST00000868809
resolver
enst
ENST00000868810
resolver
enst
ENST00000868811
resolver
enst
ENST00000968418
resolver
enst
ENST00000968419
resolver
enst
ENST00000968420
resolver
enst
ENST00000968421
resolver
enst
ENST00000968422
resolver
genesymbol
FBXO40
resolver
genesymbol_syn
FBX40
resolver
genesymbol_syn
KIAA1195
resolver
hgnc
HGNC:29816
resolver
uniprot
B2RAX7
resolver
uniprot
Q32M70
resolver
uniprot
Q9ULM5
resolver
uniprot_entry
FBX40_HUMAN
resolver
uniprot_sec
B2RAX7
resolver
uniprot_sec
Q32M70
resolver
uniprot_sec
Q9ULM5
resolver
amino_acid_sequence
MGKARRSPPGHHRHCEGCFNRHCHIPVEPNTSCLVISCHLLCGATFHMCKEAEHQLLCPLEQVPCLNSEYGCPLSMSRHKLAKHLQVCPASVVCCSMEWNRWPNVDSETTLHENIMKETPSEECLDTALALQDQKVLFRSLKMVELFPETREATEEEPTMNGETSVEEMGGAVGGVDIGLVPHGLSATNGEMAELSQEEREVLAKTKEGMDLVKFGQWENIFSKEHAASALTNSSASCESKNKNDSEKEQISSGHNMVEGEGAPKKKEPQENQKQQDVRTAMETTGLAPWQDGVLERLKTAVDAKDYNMYLVHNGRMLIHFGQMPACTPKERDFVYGKLEAQEVKTVYTFKVPVSYCGKRARLGDAMLSCKPSEHKAVDTSDLGITVEDLPKSDLIKTTLQCALERELKGHVISESRSIDGLFMDFATQTYNFEPEQFSSGTVLADLTAATPGGLHVELHSECVTRRHNKSSSAFTFTCNKFFRRDEFPLHFKNVHTDIQSCLNGWFQHRCPLAYLGCTFVQNHFRPPGQKAKVIYSQELKTFAIKPEVAPELSEGRKNNHLLGHGGKSQNSLTSLPLEILKYIAGFLDSVSLAQLSQVSVLMRNICATLLQERGMVLLQWKKKRYSHGGTSWRVHREIWQFSSLFSKIKSWEFNEVTSMSEHLKSCPFNIVEHKTDPILLTSMCQPREQARESLVSTFRIRPRGRYVS
uniprot
proteins
function
FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Acts as a muscle-specific negative regulator of IGF1 signaling. Mechanistically, promotes polyubiquitination of IRS1 following its IGF1R-induced tyrosine phosphorylation, leading to IRS1 proteasomal degradation and attenuation of the IRS1/PI3K/AKT pathway in differentiated skeletal muscle. Also mediates IRS1 degradation downstream of STAT3 activation in the context of inflammatory insulin resistance. {ECO:0000250|UniProtKB:P62932}.
uniprot
proteins
mass_dalton
79782
uniprot
proteins
pubmed
10574462
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17928169
uniprot
proteins
sequence_length
709
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62932}.
uniprot
proteins