Akr1a1
entrez
78959
canonical
uniprot
P51635
canonical
ensembl
ENSRNOG00000016727
resolver
ensembl
ENSRNOG00055013242
resolver
ensembl
ENSRNOG00060029038
resolver
ensembl
ENSRNOG00065016659
resolver
ensp
ENSRNOP00000023072
resolver
ensp
ENSRNOP00055018448
resolver
ensp
ENSRNOP00060042012
resolver
ensp
ENSRNOP00065021894
resolver
enst
ENSRNOT00000023072
resolver
enst
ENSRNOT00055022714
resolver
enst
ENSRNOT00060050456
resolver
enst
ENSRNOT00065027773
resolver
genesymbol
Akr1a1
resolver
genesymbol_syn
Alr
resolver
uniprot_entry
AK1A1_RAT
resolver
amino_acid_sequence
MTASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKYALSVGYRHIDCASVYGNETEIGEALKESVGAGKAVPREELFVTSKLWNTKHHPEDVEPAVRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTVKYDSTHYKETWKALEALVAKGLVKALGLSNFSSRQIDDVLSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHGRSPAQILLRWQVQRKVICIPKSITPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIVPMITVDGKRVPRDAGHPLYPFNDPY
uniprot
proteins
ec_number
1.1.1.19
uniprot
proteins
ec_number
1.1.1.2
uniprot
proteins
ec_number
1.1.1.20
uniprot
proteins
ec_number
1.1.1.372
uniprot
proteins
ec_number
1.1.1.54
uniprot
proteins
ec_number
1.6.-.-
uniprot
proteins
function
FUNCTION: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids (PubMed:22820017, PubMed:25152401). Plays an important role in ascorbic acid biosynthesis by catalyzing the reduction of D-glucuronic acid and D-glucurono-gamma-lactone (PubMed:22820017). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic (PubMed:25152401, PubMed:8500767). Involved also in the detoxification of lipid-derived aldehydes like acrolein (PubMed:25152401). Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs (By similarity). Also acts as an inhibitor of protein S-nitrosylation by mediating degradation of S-nitroso-coenzyme A (S-nitroso-CoA), a cofactor required to S-nitrosylate proteins (By similarity). S-nitroso-CoA reductase activity is involved in reprogramming intermediary metabolism in renal proximal tubules, notably by inhibiting protein S-nitrosylation of isoform 2 of PKM (PKM2) (By similarity). Also acts as a S-nitroso-glutathione reductase by catalyzing the NADPH-dependent reduction of S-nitrosoglutathione (By similarity). Displays no reductase activity towards retinoids (By similarity). {ECO:0000250|UniProtKB:P14550, ECO:0000250|UniProtKB:P50578, ECO:0000269|PubMed:22820017, ECO:0000269|PubMed:25152401, ECO:0000269|PubMed:8500767}.
uniprot
proteins
mass_dalton
36506
uniprot
proteins
protein_family
Aldo/keto reductase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
22820017
uniprot
proteins
pubmed
25152401
uniprot
proteins
pubmed
4463942
uniprot
proteins
pubmed
7827091
uniprot
proteins
pubmed
8500767
uniprot
proteins
sequence_length
325
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9JII6}. Apical cell membrane {ECO:0000250|UniProtKB:Q9JII6}.
uniprot
proteins