P19686
uniprot
P19686
canonical
activity_regulation
ACTIVITY REGULATION: Activated by nitric oxide in the presence of magnesium or manganese ions. NO binding to the haem of the beta subunit GUCY1B1 induces a conformational change that allosterically activates the catalytic domain. {ECO:0000250|UniProtKB:Q02108}.
uniprot
proteins
amino_acid_sequence
MFCRKFKDLKITGECPFSLLAPGQVPTEPIEEVAGVSESCQATLPTCQEFAENAEGSHPQRKTSRNRVYLHTLAESIGKLIFPEFERLNLALQRTLAKHKIKENRNSSEKEDLERIIAEEAIAAGVPVEVLKDSLGEELFKICYEEDEHILGVVGGTLKDFLNSFSTLLKQSSHCQEAERRGRLEDASILCLDKDQDFLNVYYFFPKRTTALLLPGIIKAAARILYESHVEVSLMPPCFRSECTEFVNQPYLLYSVHVKSTKPSLSPGKPQSSLVIPTSLFCKTFPFHFMLDRDLAILQLGNGIRRLVNKRDFQGKPNFEEFFEILTPKINQTFSGIMTMLNMQFVIRVRRWDNLVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEHAHQALEEEKKKTVDLLCSIFPSEVAQQLWQGQIVQAKKFNEVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHRESDTHAVQIALMALKMMELSNEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSDIPGICHFLDAYQHQGPNSKPWFQQKDAEDGNANFLGKASGVD
uniprot
proteins
ec_number
4.6.1.2
uniprot
proteins
function
FUNCTION: Alpha subunit of soluble guanylate cyclase (sGC), a key enzyme in nitric oxide (NO) signaling. sGC functions as a heterodimer consisting of one alpha and one beta subunit. It serves as the primary intracellular receptor for NO, which binds to a heme prosthetic group located on the beta subunit. Upon NO binding, sGC catalyzes the conversion of GTP into cyclic GMP (cGMP), thereby transmitting the NO signal into an ubiquitous intracellular second messenger. {ECO:0000250|UniProtKB:Q02108}.
uniprot
proteins
mass_dalton
77567
uniprot
proteins
protein_family
Adenylyl cyclase class-4/guanylyl cyclase family
uniprot
proteins
pubmed
1698769
uniprot
proteins
pubmed
8997507
uniprot
proteins
sequence_length
690
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
uniprot
proteins