Rap2b
entrez
74012
canonical
uniprot
P61226
canonical
ensembl
ENSMUSG00000036894
resolver
ensp
ENSMUSP00000038841
resolver
enst
ENSMUST00000049064
resolver
genesymbol
Rap2b
resolver
uniprot
P17964
resolver
uniprot
Q6ZWR0
resolver
uniprot
Q96EG5
resolver
uniprot
Q9CXG0
resolver
uniprot_entry
Q6ZWR0_MOUSE
resolver
uniprot_entry
RAP2B_MOUSE
resolver
uniprot_sec
P17964
resolver
uniprot_sec
Q96EG5
resolver
uniprot_sec
Q9CXG0
resolver
amino_acid_sequence
MREYKVVVLGSGGVGKSALTVQFVTGSFIEKYDPTIEDFYRKEIEVDSSPSVLEILDTAGTEQFASMRDLYIKNGQGFILVYSLVNQQSFQDIKPMRDQIIRVKRYERVPMILVGNKVDLEGEREVSYGEGKALAEEWSCPFMETSAKNKASVDELFAEIVRQMNYAAQPNGDEGCCSACVIL
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. Involved in EGFR and CHRM3 signaling pathways through stimulation of PLCE1. May play a role in cytoskeletal rearrangements and regulate cell spreading through activation of the effector TNIK. May regulate membrane vesiculation in red blood cells. {ECO:0000269|PubMed:19061864}.
uniprot
proteins
mass_dalton
20504
uniprot
proteins
mutagenesis
MUTAGEN 176; /note="C->G: No reduction of association with the recycling endosome membranes and does activate TNIK; when associated with G-177."; /evidence="ECO:0000269|PubMed:19061864"; MUTAGEN 177; /note="C->G: No reduction of association with the recycling endosome membranes and does activate TNIK; when associated with G-176."; /evidence="ECO:0000269|PubMed:19061864"; MUTAGEN 180; /note="C->A: Loss of association with membranes."; /evidence="ECO:0000269|PubMed:19061864
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. Unlike RAP2A and RAP2C, palmitoylation of RAP2B is not required for association with recycling endosome membranes and activation of TNIK. {ECO:0000269|PubMed:19061864}.
uniprot
proteins
protein_family
Ras family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19061864
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9523700
uniprot
proteins
sequence_length
183
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000269|PubMed:19061864}; Lipid-anchor {ECO:0000269|PubMed:19061864}; Cytoplasmic side {ECO:0000269|PubMed:19061864}. Note=Associated with red blood cells-released vesicles. {ECO:0000250}.
uniprot
proteins