Q63373
uniprot
Q63373
canonical
amino_acid_sequence
MYQRMLRCGAELGSPGGGSSGGAGGRLALLWIVPLTLSGLLGVAWGASSLGAHHIHHFHGSSKHHSVPIAIYRSPASLRGGHAGTTYIFSKGGGQITYKWPPNDRPSTRADRLAIGFSTVQKEAVLVRVDSSSGLGDYLELHIHQGKIGVKFNVGTDDIAIEESNAIINDGKYHVVRFTRSGGNATLQVDSWPVIERYPAGNNDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQATIIIGGKEQGQPFQGQLSGLYYNGLKVLNMAAENDANIAIVGNVRLVGEVPSSMTTESTATAMQSEMSTSIMETTTTLATSTARRGKPPTKEPISQTTDDILVASAECPSDDEDIDPCEPSSGGLANPTRVGGREPYPGSAEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYHVDESRNYISNSAQSNGAVVKEKQPSSAKSANKNKKNKDKEYYV
uniprot
proteins
function
FUNCTION: Neuronal cell surface protein involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins (PubMed:9325340). Plays a role in formation of synaptic junctions (By similarity). Functions as part of a trans-synaptic complex by binding to cerebellins and postsynaptic GRID1. This interaction helps regulate the activity of NMDA and AMPA receptors at hippocampal synapses without affecting synapse formation. NRXN1B-CBLN2-GRID1 complex transduce presynaptic signals into postsynaptic NMDAR response (By similarity). {ECO:0000250|UniProtKB:P0DI97, ECO:0000269|PubMed:9325340}.
uniprot
proteins
mass_dalton
50268
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:8163501}.; PTM: O-glycosylated; contains heparan sulfate. Heparan sulfate attachment is required for synapse development by mediating interactions with neuroligins. {ECO:0000250|UniProtKB:P0DI97}.
uniprot
proteins
protein_family
Neurexin family
uniprot
proteins
pubmed
10197529
uniprot
proteins
pubmed
10520997
uniprot
proteins
pubmed
11470830
uniprot
proteins
pubmed
1621094
uniprot
proteins
pubmed
17042500
uniprot
proteins
pubmed
17868325
uniprot
proteins
pubmed
18093521
uniprot
proteins
pubmed
8163501
uniprot
proteins
pubmed
8576240
uniprot
proteins
pubmed
8786425
uniprot
proteins
pubmed
9325340
uniprot
proteins
sequence_length
468
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Presynaptic cell membrane {ECO:0000269|PubMed:17868325}; Single-pass type I membrane protein {ECO:0000269|PubMed:17868325}.
uniprot
proteins
transmembrane_region
TRANSMEM 392..414; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins