Gabra2
entrez
14395
canonical
uniprot
P26048
canonical
ensembl
ENSMUSG00000000560
resolver
ensp
ENSMUSP00000142892
resolver
ensp
ENSMUSP00000256357
resolver
enst
ENSMUST00000197284
resolver
genesymbol
Gabra2
resolver
genesymbol_syn
Gabra-2
resolver
uniprot
Q544G1
resolver
uniprot_entry
GBRA2_MOUSE
resolver
uniprot_entry
Q544G1_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Activated by pentobarbital (By similarity). Inhibited by the antagonist bicuculline (By similarity). {ECO:0000250|UniProtKB:P10063}.
uniprot
proteins
amino_acid_sequence
MKTKLSTCNVWSLLLVLLVWDPVRLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKGSVMIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRMSRIVFPVLFGTFNLVYWATYLNREPVLGVSP
uniprot
proteins
function
FUNCTION: Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:27129275). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). The alpha-2 subunit exhibits synaptogenic activity together with beta-2 and very little to no activity together with beta-3, the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (PubMed:27129275). {ECO:0000250|UniProtKB:P10063, ECO:0000250|UniProtKB:P14867, ECO:0000269|PubMed:27129275}.
uniprot
proteins
mass_dalton
51139
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:27129275}.
uniprot
proteins
protein_family
GABRA2 sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
11528422
uniprot
proteins
pubmed
1356407
uniprot
proteins
pubmed
27129275
uniprot
proteins
pubmed
28978485
uniprot
proteins
pubmed
31601770
uniprot
proteins
sequence_length
451
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000269|PubMed:11528422}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:11528422, ECO:0000269|PubMed:28978485}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P23576}. Cell projection, dendrite {ECO:0000269|PubMed:28978485}.
uniprot
proteins
transmembrane_region
TRANSMEM 250..270; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 281..300; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 312..332; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 421..441; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins