SLC51A
entrez
200931
canonical
uniprot
Q86UW1
canonical
ensembl
ENSG00000163959
resolver
ensp
ENSP00000296327
resolver
ensp
ENSP00000570706
resolver
enst
ENST00000296327
resolver
enst
ENST00000900647
resolver
genesymbol
SLC51A
resolver
genesymbol_syn
OSTA
resolver
hgnc
HGNC:29955
resolver
uniprot
Q6ZMC7
resolver
uniprot_entry
OSTA_HUMAN
resolver
uniprot_sec
Q6ZMC7
resolver
amino_acid_sequence
MEPGRTQIKLDPRYTADLLEVLKTNYGIPSACFSQPPTAAQLLRALGPVELALTSILTLLALGSIAIFLEDAVYLYKNTLCPIKRRTLLWKSSAPTVVSVLCCFGLWIPRSLVLVEMTITSFYAVCFYLLMLVMVEGFGGKEAVLRTLRDTPMMVHTGPCCCCCPCCPRLLLTRKKLQLLMLGPFQYAFLKITLTLVGLFLVPDGIYDPADISEGSTALWINTFLGVSTLLALWTLGIISRQARLHLGEQNMGAKFALFQVLLILTALQPSIFSVLANGGQIACSPPYSSKTRSQVMNCHLLILETFLMTVLTRMYYRRKDHKVGYETFSSPDLDLNLKA
uniprot
proteins
disease_involvement
DISEASE: Cholestasis, progressive familial intrahepatic, 6 (PFIC6) [MIM:619484]: An autosomal recessive form of progressive cholestasis, a disorder characterized by early onset of cholestasis that progresses to hepatic fibrosis, cirrhosis, and end-stage liver disease. PFIC6 patients have elevated liver transaminases and congenital diarrhea. {ECO:0000269|PubMed:31863603}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Essential component of the OST-alpha/OST-beta complex, a heterotetramer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood (PubMed:16317684, PubMed:41606314, PubMed:41606328). The OST-alpha/OST-beta complex efficiently transports the major species of bile acids (taurocholate) (PubMed:16317684, PubMed:41606314, PubMed:41606328). Taurine conjugates are transported more efficiently across the basolateral membrane than glycine-conjugated bile acids (By similarity). In the complex, SLC51A/OST-alpha adopts a G protein-coupled receptor fold and constitutes a bile acid recognition site (PubMed:41606314, PubMed:41606328). Can also transport steroids such as estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, therefore playing a role in the enterohepatic circulation of sterols (PubMed:16317684). Able to transport eicosanoids such as prostaglandin E2 (By similarity). {ECO:0000250|UniProtKB:Q8R000, ECO:0000250|UniProtKB:Q90YM5, ECO:0000269|PubMed:16317684, ECO:0000269|PubMed:41606314, ECO:0000269|PubMed:41606328}.
uniprot
proteins
mass_dalton
37735
uniprot
proteins
mutagenesis
MUTAGEN 32; /note="C->A,S: Strongly decreased bile acid transport."; /evidence="ECO:0000269|PubMed:41606314"; MUTAGEN 86; /note="R->A: Does not affect bile acid transport."; /evidence="ECO:0000269|PubMed:41606314"; MUTAGEN 90; /note="W->A: Decreased bile acid transport."; /evidence="ECO:0000269|PubMed:41606314"; MUTAGEN 116; /note="E->A: Decreased bile acid transport."; /evidence="ECO:0000269|PubMed:41606328"; MUTAGEN 128; /note="Y->A: Decreased bile acid transport."; /evidence="ECO:0000269|PubMed:41606314"; MUTAGEN 141; /note="K->A: Does not affect bile acid transport."; /evidence="ECO:0000269|PubMed:41606314"; MUTAGEN 156; /note="H->A: Decreased bile acid transport."; /evidence="ECO:0000269|PubMed:41606328"; MUTAGEN 160; /note="C->A: Decreased bile acid transport."; /evidence="ECO:0000269|PubMed:41606314"; MUTAGEN 161; /note="C->A: Decreased bile acid transport."; /evidence="ECO:0000269|PubMed:41606314, ECO:0000269|PubMed:41606328"; MUTAGEN 162; /note="C->A: Strongly decreased bile acid transport."; /evidence="ECO:0000269|PubMed:41606314"; MUTAGEN 166; /note="C->A: Decreased bile acid transport."; /evidence="ECO:0000269|PubMed:41606314"; MUTAGEN 167; /note="C->A: Decreased bile acid transport."; /evidence="ECO:0000269|PubMed:41606314"; MUTAGEN 191; /note="K->A: Decreased bile acid transport."; /evidence="ECO:0000269|PubMed:41606328"; MUTAGEN 200; /note="F->A: Does not affect bile acid transport."; /evidence="ECO:0000269|PubMed:41606314"; MUTAGEN 204; /note="D->A: Decreased bile acid transport."; /evidence="ECO:0000269|PubMed:41606314"; MUTAGEN 222; /note="N->A: Decreased bile acid transport."; /evidence="ECO:0000269|PubMed:41606328"; MUTAGEN 234; /note="W->A,I: Decreased bile acid transport."; /evidence="ECO:0000269|PubMed:41606328"; MUTAGEN 241; /note="R->A: Decreased bile acid transport."; /evidence="ECO:0000269|PubMed:41606328"; MUTAGEN 244; /note="R->A: Decreased bile acid transport."; /evidence="ECO:0000269|PubMed:41606328"; MUTAGEN 260; /note="Q->A: Decreased bile acid transport."; /evidence="ECO:0000269|PubMed:41606328"; MUTAGEN 274; /note="S->A: Decreased bile acid transport."; /evidence="ECO:0000269|PubMed:41606328"; MUTAGEN 284; /note="C->A,S: Strongly decreased bile acid transport."; /evidence="ECO:0000269|PubMed:41606314"; MUTAGEN 291; /note="K->A: Decreased bile acid transport."; /evidence="ECO:0000269|PubMed:41606328
uniprot
proteins
post_translational_modification
PTM: Palmitoylation of the cysteine-rich loop is required to form a lateral substrate-binding groove for recognition of bile acids. {ECO:0000269|PubMed:41606314, ECO:0000269|PubMed:41606328}.
uniprot
proteins
protein_family
OST-alpha family
uniprot
proteins
pubmed
12719432
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16251721
uniprot
proteins
pubmed
16269519
uniprot
proteins
pubmed
16317684
uniprot
proteins
pubmed
31863603
uniprot
proteins
pubmed
41606314
uniprot
proteins
pubmed
41606328
uniprot
proteins
sequence_length
340
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:16317684}; Multi-pass membrane protein. Note=Transported from the endoplasmic reticulum to the plasma membrane upon interacting with SLC51B (By similarity). Mainly restricted to the lateral and basal membranes of ileal enterocytes (By similarity). {ECO:0000250|UniProtKB:Q8R000}.
uniprot
proteins
transmembrane_region
TRANSMEM 49..80; /note="Helical; Name=TM1"; /evidence="ECO:0000269|PubMed:41606328, ECO:0007744|PDB:9LJG, ECO:0007744|PDB:9LJH, ECO:0007744|PDB:9UNV, ECO:0007744|PDB:9UO1, ECO:0007744|PDB:9UO2"; TRANSMEM 83..108; /note="Helical; Name=TM2"; /evidence="ECO:0000269|PubMed:41606328, ECO:0007744|PDB:9LJG, ECO:0007744|PDB:9LJH, ECO:0007744|PDB:9UNV, ECO:0007744|PDB:9UO1, ECO:0007744|PDB:9UO2"; TRANSMEM 110..139; /note="Helical; Name=TM3"; /evidence="ECO:0000269|PubMed:41606328, ECO:0007744|PDB:9LJG, ECO:0007744|PDB:9LJH, ECO:0007744|PDB:9UNV, ECO:0007744|PDB:9UO1, ECO:0007744|PDB:9UO2"; TRANSMEM 174..202; /note="Helical; Name=TM4"; /evidence="ECO:0000269|PubMed:41606328, ECO:0007744|PDB:9LJG, ECO:0007744|PDB:9LJH, ECO:0007744|PDB:9UNV, ECO:0007744|PDB:9UO1, ECO:0007744|PDB:9UO2"; TRANSMEM 218..246; /note="Helical; Name=TM5"; /evidence="ECO:0000269|PubMed:41606328, ECO:0007744|PDB:9LJG, ECO:0007744|PDB:9LJH, ECO:0007744|PDB:9UNV, ECO:0007744|PDB:9UO1, ECO:0007744|PDB:9UO2"; TRANSMEM 249..278; /note="Helical; Name=TM6"; /evidence="ECO:0000269|PubMed:41606328, ECO:0007744|PDB:9LJG, ECO:0007744|PDB:9LJH, ECO:0007744|PDB:9UNV, ECO:0007744|PDB:9UO1, ECO:0007744|PDB:9UO2"; TRANSMEM 294..317; /note="Helical; Name=TM7"; /evidence="ECO:0000269|PubMed:41606328, ECO:0007744|PDB:9LJG, ECO:0007744|PDB:9LJH, ECO:0007744|PDB:9UNV, ECO:0007744|PDB:9UO1, ECO:0007744|PDB:9UO2
uniprot
proteins