B4GALT4
entrez
8702
canonical
uniprot
O60513
canonical
ensembl
ENSG00000121578
resolver
ensp
ENSP00000352144
resolver
ensp
ENSP00000377360
resolver
ensp
ENSP00000420161
resolver
ensp
ENSP00000420665
resolver
ensp
ENSP00000576998
resolver
ensp
ENSP00000577000
resolver
ensp
ENSP00000577001
resolver
ensp
ENSP00000577002
resolver
ensp
ENSP00000577004
resolver
ensp
ENSP00000577005
resolver
ensp
ENSP00000577006
resolver
ensp
ENSP00000577007
resolver
ensp
ENSP00000577008
resolver
ensp
ENSP00000577009
resolver
ensp
ENSP00000577010
resolver
ensp
ENSP00000577011
resolver
ensp
ENSP00000577012
resolver
ensp
ENSP00000582651
resolver
ensp
ENSP00000582652
resolver
ensp
ENSP00000582653
resolver
ensp
ENSP00000622728
resolver
ensp
ENSP00000622729
resolver
ensp
ENSP00000622730
resolver
ensp
ENSP00000622732
resolver
ensp
ENSP00000622733
resolver
ensp
ENSP00000622734
resolver
ensp
ENSP00000622735
resolver
ensp
ENSP00000622736
resolver
ensp
ENSP00000622737
resolver
ensp
ENSP00000622738
resolver
ensp
ENSP00000622740
resolver
ensp
ENSP00000622741
resolver
ensp
ENSP00000622742
resolver
ensp
ENSP00000622743
resolver
ensp
ENSP00000622744
resolver
ensp
ENSP00000678191
resolver
enst
ENST00000359213
resolver
enst
ENST00000393765
resolver
enst
ENST00000480814
resolver
enst
ENST00000483209
resolver
enst
ENST00000906939
resolver
enst
ENST00000906941
resolver
enst
ENST00000906942
resolver
enst
ENST00000906943
resolver
enst
ENST00000906945
resolver
enst
ENST00000906946
resolver
enst
ENST00000906947
resolver
enst
ENST00000906948
resolver
enst
ENST00000906949
resolver
enst
ENST00000906950
resolver
enst
ENST00000906951
resolver
enst
ENST00000906952
resolver
enst
ENST00000906953
resolver
enst
ENST00000912592
resolver
enst
ENST00000912593
resolver
enst
ENST00000912594
resolver
enst
ENST00000952669
resolver
enst
ENST00000952670
resolver
enst
ENST00000952671
resolver
enst
ENST00000952673
resolver
enst
ENST00000952674
resolver
enst
ENST00000952675
resolver
enst
ENST00000952676
resolver
enst
ENST00000952677
resolver
enst
ENST00000952678
resolver
enst
ENST00000952679
resolver
enst
ENST00000952681
resolver
enst
ENST00000952682
resolver
enst
ENST00000952683
resolver
enst
ENST00000952684
resolver
enst
ENST00000952685
resolver
genesymbol
B4GALT4
resolver
hgnc
HGNC:927
resolver
uniprot
B2RAZ5
resolver
uniprot
B3KM35
resolver
uniprot
D3DN79
resolver
uniprot
E7ETS9
resolver
uniprot
Q68D68
resolver
uniprot
Q9BSW3
resolver
uniprot
Q9C078
resolver
uniprot_entry
B2RAZ5_HUMAN
resolver
uniprot_entry
B3KM35_HUMAN
resolver
uniprot_entry
B4GT4_HUMAN
resolver
uniprot_entry
E7ETS9_HUMAN
resolver
uniprot_sec
D3DN79
resolver
uniprot_sec
Q68D68
resolver
uniprot_sec
Q9BSW3
resolver
uniprot_sec
Q9C078
resolver
activity_regulation
ACTIVITY REGULATION: Up-regulated by LALBA. {ECO:0000269|PubMed:9792633}.
uniprot
proteins
amino_acid_sequence
MGFNLTFHLSYKFRLLLLLTLCLTVVGWATSNYFVGAIQEIPKAKEFMANFHKTLILGKGKTLTNEASTKKVELDNCPSVSPYLRGQSKLIFKPDLTLEEVQAENPKVSRGRYRPQECKALQRVAILVPHRNREKHLMYLLEHLHPFLQRQQLDYGIYVIHQAEGKKFNRAKLLNVGYLEALKEENWDCFIFHDVDLVPENDFNLYKCEEHPKHLVVGRNSTGYRLRYSGYFGGVTALSREQFFKVNGFSNNYWGWGGEDDDLRLRVELQRMKISRPLPEVGKYTMVFHTRDKGNEVNAERMKLLHQVSRVWRTDGLSSCSYKLVSVEHNPLYINITVDFWFGA
uniprot
proteins
ec_number
2.4.1.-
uniprot
proteins
ec_number
2.4.1.275
uniprot
proteins
ec_number
2.4.1.90
uniprot
proteins
function
FUNCTION: Galactose (Gal) transferase involved in the synthesis of terminal N-acetyllactosamine (LacNac) unit present on glycan chains of glycoproteins and glycosphingolipids (PubMed:12511560, PubMed:17690104, PubMed:32827291, PubMed:9792633). Catalyzes the transfer of Gal residue via a beta1->4 linkage from UDP-Gal to the non-reducing terminal N-acetyl glucosamine 6-O-sulfate (6-O-sulfoGlcNAc) in the linearly growing chain of both N- and O-linked keratan sulfate proteoglycans. Cooperates with B3GNT7 N-acetyl glucosamine transferase and CHST6 and CHST1 sulfotransferases to construct and elongate mono- and disulfated disaccharide units [->3Galbeta1->4(6-sulfoGlcNAcbeta)1->] and [->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer (PubMed:17690104). Transfers Gal residue via a beta1->4 linkage to terminal 6-O-sulfoGlcNAc within the LacNac unit of core 2 O-glycans forming 6-sulfo-sialyl-Lewis X (sLex). May contribute to the generation of sLex epitope on mucin-type glycoproteins that serve as ligands for SELL/L-selectin, a major regulator of leukocyte migration (PubMed:12511560). In the biosynthesis pathway of neolacto-series glycosphingolipids, transfers Gal residue via a beta1->4 linkage to terminal GlcNAc of a lactotriaosylceramide (Lc3Cer) acceptor to form a neolactotetraosylceramide (PubMed:9792633). Efficiently galactosylates both non-sulfated and 6-O-sulfated terminal GlcNAc moities on G0 complex-type N-glycans. {ECO:0000269|PubMed:12511560, ECO:0000269|PubMed:17690104, ECO:0000269|PubMed:32827291, ECO:0000269|PubMed:35939855, ECO:0000269|PubMed:9792633}.
uniprot
proteins
mass_dalton
40041
uniprot
proteins
mutagenesis
MUTAGEN 6; /note="T->A: Has no impact on N-glycosylation."; /evidence="ECO:0000269|PubMed:32827291"; MUTAGEN 222; /note="T->A: Has no impact on localization to the Golgi apparatus. Decreases N-glycosylation. Impairs the catalytic activity. Impairs keratan sulfate biosynthesis; when associated with A-337."; /evidence="ECO:0000269|PubMed:32827291"; MUTAGEN 337; /note="T->A: Impairs localization to the Golgi apparatus. Abolishes N-glycosylation. Impairs the interaction with SLC35A/UGT1. Impairs the catalytic activity. Impairs keratan sulfate biosynthesis; when associated with A-222."; /evidence="ECO:0000269|PubMed:32827291
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000305|PubMed:12511560}.; PATHWAY: Glycolipid biosynthesis. {ECO:0000305|PubMed:9792633}.
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:32827291}.
uniprot
proteins
protein_family
Glycosyltransferase 7 family
uniprot
proteins
pubmed
10580128
uniprot
proteins
pubmed
11588157
uniprot
proteins
pubmed
12511560
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17690104
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
32827291
uniprot
proteins
pubmed
35939855
uniprot
proteins
pubmed
9597550
uniprot
proteins
pubmed
9792633
uniprot
proteins
sequence_length
344
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:32827291}; Single-pass type II membrane protein {ECO:0000255}. Secreted {ECO:0000269|PubMed:32827291}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..38; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins