Cnot6l
entrez
231464
canonical
uniprot
Q8VEG6
canonical
ensembl
ENSMUSG00000034724
resolver
ensp
ENSMUSP00000108629
resolver
ensp
ENSMUSP00000119415
resolver
ensp
ENSMUSP00000228294
resolver
genesymbol
Cnot6l
resolver
uniprot
Q3U9M0
resolver
uniprot
Q8C0P4
resolver
uniprot_entry
CNO6L_MOUSE
resolver
uniprot_sec
Q3U9M0
resolver
uniprot_sec
Q8C0P4
resolver
amino_acid_sequence
MRLIGMPKEKYDPPDPRRIYTIMSAEEVANGKKSHWAELEISGRVRSLSTSLWSLTHLTALHLNDNNLARIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNDNYLRVLPYELGRLFQLQTLGLTGNPLSQDIMSLYQDPDGTRKLLNFMLDNLAVHPEQLPPRPWITLKERDQILPSASFTVMCYNVLCDKYATRQLYGYCPSWALNWEYRKKGIMEEIVNWDADIISLQEVETEQYFTLFLPALKDRGYDGFFSPKSRAKIMSEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQVAMANSDGSEAMLNRVMTKDNIGVAVVLEVHKELFGTGMKPIHAADKQLLIVANAHMHWDPEYSDVKLIQTMMFVSEVKNILEKASSRPGSPTADPNSIPLVLCADLNSLPDSGVVEYLSNGGVADNHKDFKELRYNECLMNFSCSGKNGSSEGRITHGFQLKSAYENNLMPYTNYTFDFKGVIDYIFYSKTHMNVLGVLGPLDPQWLVENNITGCPHPHIPSDHFSLLTQLELHPPLLPLVNGVHLPNRR
uniprot
proteins
ec_number
3.1.13.4
uniprot
proteins
function
FUNCTION: Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
63023
uniprot
proteins
protein_family
CCR4/nocturin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20133598
uniprot
proteins
pubmed
21078877
uniprot
proteins
pubmed
22367759
uniprot
proteins
pubmed
36001654
uniprot
proteins
sequence_length
555
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96LI5}. Nucleus {ECO:0000250|UniProtKB:Q96LI5}. Note=Predominantly cytoplasmic. {ECO:0000250|UniProtKB:Q96LI5}.
uniprot
proteins