Il10ra
entrez
16154
canonical
uniprot
Q61727
canonical
ensembl
ENSMUSG00000032089
resolver
ensp
ENSMUSP00000034594
resolver
ensp
ENSMUSP00000135461
resolver
enst
ENSMUST00000034594
resolver
enst
ENSMUST00000176222
resolver
genesymbol
Il10ra
resolver
genesymbol_syn
Il10r
resolver
uniprot
H3BKN6
resolver
uniprot
Q3U6I9
resolver
uniprot
Q3UDL4
resolver
uniprot
Q3UDV8
resolver
uniprot
Q3UE89
resolver
uniprot_entry
H3BKN6_MOUSE
resolver
uniprot_entry
I10R1_MOUSE
resolver
uniprot_entry
Q3U6I9_MOUSE
resolver
uniprot_entry
Q3UDL4_MOUSE
resolver
uniprot_entry
Q3UDV8_MOUSE
resolver
uniprot_entry
Q3UE89_MOUSE
resolver
amino_acid_sequence
MLSRLLPFLVTISSLSLEFIAYGTELPSPSYVWFEARFFQHILHWKPIPNQSESTYYEVALKQYGNSTWNDIHICRKAQALSCDLTTFTLDLYHRSYGYRARVRAVDNSQYSNWTTTETRFTVDEVILTVDSVTLKAMDGIIYGTIHPPRPTITPAGDEYEQVFKDLRVYKISIRKFSELKNATKRVKQETFTLTVPIGVRKFCVKVLPRLESRINKAEWSEEQCLLITTEQYFTVTNLSILVISMLLFCGILVCLVLQWYIRHPGKLPTVLVFKKPHDFFPANPLCPETPDAIHIVDLEVFPKVSLELRDSVLHGSTDSGFGSGKPSLQTEESQFLLPGSHPQIQGTLGKEESPGLQATCGDNTDSGICLQEPGLHSSMGPAWKQQLGYTHQDQDDSDVNLVQNSPGQPKYTQDASALGHVCLLEPKAPEEKDQVMVTFQGYQKQTRWKAEAAGPAECLDEEIPLTDAFDPELGVHLQDDLAWPPPALAAGYLKQESQGMASAPPGTPSRQWNQLTEEWSLLGVVSCEDLSIESWRFAHKLDPLDCGAAPGGLLDSLGSNLVTLPLISSLQVEE
uniprot
proteins
function
FUNCTION: Cell surface receptor for the cytokine IL10 that participates in IL10-mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well. In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively. These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3 (PubMed:8910398). Once phosphorylated, STAT3 homodimerizes, translocates to the nucleus and activates the expression of anti-inflammatory genes. In addition, IL10RA-mediated activation of STAT3 inhibits starvation-induced autophagy (By similarity). {ECO:0000250|UniProtKB:Q13651, ECO:0000269|PubMed:8910398}.
uniprot
proteins
mass_dalton
64248
uniprot
proteins
mutagenesis
MUTAGEN 443; /note="Y->F: Complete loss of STAT3 activation; in association with F-493."; /evidence="ECO:0000269|PubMed:8910398"; MUTAGEN 493; /note="Y->F: Complete loss of STAT3 activation; in association with F-443."; /evidence="ECO:0000269|PubMed:8910398
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation of the cytoplasmic tail induced STAT3 activation. {ECO:0000269|PubMed:8910398}.; PTM: Ubiquitinated by BTRC; ubiquitination leads to endocytosis and subsequent degradation of IL10RA. {ECO:0000250|UniProtKB:Q13651}.
uniprot
proteins
protein_family
Type II cytokine receptor family
uniprot
proteins
pubmed
8248239
uniprot
proteins
pubmed
8910398
uniprot
proteins
sequence_length
575
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q13651}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q13651}. Cytoplasm {ECO:0000250|UniProtKB:Q13651}.
uniprot
proteins
transmembrane_region
TRANSMEM 242..262; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins