Dclre1c
entrez
259171
canonical
uniprot
Q5XIX3
canonical
ensembl
ENSRNOG00000015980
resolver
ensp
ENSRNOP00000102035
resolver
genesymbol
Dclre1c
resolver
genesymbol_syn
Snm1l
resolver
uniprot
Q8K4H7
resolver
uniprot_entry
DCR1C_RAT
resolver
uniprot_sec
Q8K4H7
resolver
amino_acid_sequence
MSSFQGQMEEYPTISIDRFDRENLKARAYFLSHCHKDHMKGLRAPSMKRRLECSLKVFLYCSPVTKELLLTSPKYKFWENRIIAIEIETPTQVSLVDEASGEKEEVVVTLLPAGHCPGSVMFLFQGSNGTVLYTGDFRLAKGEVSRMELLHSGGRVKDIQSVYLDTTFCDPRFYQIPSREECLRGVLELVRSWITRSPKHVVWLNCKAAYGYEYLFTNLSEELGVQVHVDKLDMFKNMPDILHHLTTDRNTQIHACRHPKAEEYFQWNKLPCGMASKTKTVLHTISIKPSTMWFGERTRKTNVIVRTGESSYRACFSFHSSYSEIKDFLSYICPVNAYPNVIPIGLTVDKVMDFLKPLCRSSQCAEPKYKPLGKLKRARTVHLDSEEDDDLFDDPLLTHSRRKVPYQVTLHPEVFSMKALPLDQPELGQSPGCCKAESMPSPSLANFVDCDESNSDSEGELETPPSLQGGLGPTTLPQQNADPDVDVPRWEVFFKRKDEITDECLENLPSSIETGGSQSPKRFSDSPKLGSDSDGESTHISSQNSSQSTHITDQGSQGWDSQCDTVLLSSQEKSGGDSTSLNKDTYKPKPKDSISASQIEQNALCPQDTHCDLKSGAEVNGVPCIEEPDTVSGRKSSPEKTSLTSTQADSQSSSDFEIPSTPEAELPKPEHLQFLYGKLATGESIVLKKENVHSQIFK
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and signal joints respectively. This protein exhibits single-strand specific 5'-3' exonuclease activity in isolation, and acquires endonucleolytic activity on 5' and 3' hairpins and overhangs when in a complex with PRKDC. The latter activity is required specifically for the resolution of closed hairpins prior to the formation of the coding joint. May also be required for the repair of complex DSBs induced by ionizing radiation, which require substantial end-processing prior to religation by NHEJ (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
78189
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on undefined residues by PRKDC may stimulate endonucleolytic activity on 5' and 3' hairpins and overhangs. PRKDC must remain present, even after phosphorylation, for efficient hairpin opening. Also phosphorylated by ATM in response to ionizing radiation (IR) and by ATR in response to ultraviolet (UV) radiation (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
DNA repair metallo-beta-lactamase (DRMBL) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
698
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins