HLA
entrez
3107
canonical
uniprot
P10321
canonical
ensembl
ENSG00000204525
resolver
ensembl
ENSG00000233841
resolver
ensp
ENSP00000365402
resolver
ensp
ENSP00000414063
resolver
enst
ENST00000424832
resolver
genesymbol
HLA
resolver
genesymbol
HLA-C
resolver
genesymbol
HLA-Cw
resolver
genesymbol_syn
HLA-C
resolver
genesymbol_syn
HLAC
resolver
hgnc
HGNC:4933
resolver
uniprot
A0A090KMD8
resolver
uniprot
A0A160YHC2
resolver
uniprot
A0AAT9V8T4
resolver
uniprot
O02863
resolver
uniprot
O02864
resolver
uniprot
O02865
resolver
uniprot
O02866
resolver
uniprot
O02958
resolver
uniprot
O19505
resolver
uniprot
O19617
resolver
uniprot
O19652
resolver
uniprot
O19676
resolver
uniprot
O62879
resolver
uniprot
O62882
resolver
uniprot
O62883
resolver
uniprot
O62888
resolver
uniprot
O78060
resolver
uniprot
O78061
resolver
uniprot
O78062
resolver
uniprot
O78063
resolver
uniprot
O78067
resolver
uniprot
O78068
resolver
uniprot
O78069
resolver
uniprot
O78072
resolver
uniprot
O78083
resolver
uniprot
O78090
resolver
uniprot
O78091
resolver
uniprot
O78149
resolver
uniprot
O78165
resolver
uniprot
O78166
resolver
uniprot
O78178
resolver
uniprot
O78202
resolver
uniprot
O78203
resolver
uniprot
O78211
resolver
uniprot
O78214
resolver
uniprot
P04222
resolver
uniprot
P30499
resolver
uniprot
P30500
resolver
uniprot
P30501
resolver
uniprot
P30502
resolver
uniprot
P30503
resolver
uniprot
P30504
resolver
uniprot
P30505
resolver
uniprot
P30506
resolver
uniprot
P30507
resolver
uniprot
P30508
resolver
uniprot
P30509
resolver
uniprot
P30510
resolver
uniprot
P79498
resolver
uniprot
Q07000
resolver
uniprot
Q29631
resolver
uniprot
Q29641
resolver
uniprot
Q29643
resolver
uniprot
Q29652
resolver
uniprot
Q29743
resolver
uniprot
Q29768
resolver
uniprot
Q29862
resolver
uniprot
Q29864
resolver
uniprot
Q29865
resolver
uniprot
Q29867
resolver
uniprot
Q29921
resolver
uniprot
Q29959
resolver
uniprot
Q29960
resolver
uniprot
Q29963
resolver
uniprot
Q29986
resolver
uniprot
Q29989
resolver
uniprot
Q29990
resolver
uniprot
Q29991
resolver
uniprot
Q29992
resolver
uniprot
Q29993
resolver
uniprot
Q30192
resolver
uniprot
Q31605
resolver
uniprot
Q31627
resolver
uniprot
Q6R739
resolver
uniprot
Q860R1
resolver
uniprot
Q860R2
resolver
uniprot
Q95463
resolver
uniprot
Q95603
resolver
uniprot
Q95604
resolver
uniprot
Q95HC2
resolver
uniprot
Q99528
resolver
uniprot
Q9BD28
resolver
uniprot
Q9GIK4
resolver
uniprot
Q9GIK8
resolver
uniprot
Q9GJ33
resolver
uniprot
Q9MY30
resolver
uniprot
Q9MY31
resolver
uniprot
Q9MY35
resolver
uniprot
Q9MY49
resolver
uniprot
Q9MY74
resolver
uniprot
Q9MYI3
resolver
uniprot
Q9TNN7
resolver
uniprot
Q9TNZ8
resolver
uniprot
Q9TPS4
resolver
uniprot
Q9TPV8
resolver
uniprot
Q9TPX2
resolver
uniprot
Q9TQB4
resolver
uniprot
Q9TQJ5
resolver
uniprot
Q9TQP9
resolver
uniprot
Q9UM32
resolver
uniprot
Q9UM33
resolver
uniprot
Q9UM42
resolver
uniprot
Q9UQS9
resolver
uniprot_entry
A0AAT9V8T4_HUMAN
resolver
uniprot_entry
HLAC_HUMAN
resolver
uniprot_entry
O19617_HUMAN
resolver
uniprot_entry
Q6R739_HUMAN
resolver
uniprot_entry
Q95HC2_HUMAN
resolver
uniprot_sec
A0A090KMD8
resolver
uniprot_sec
A0A160YHC2
resolver
uniprot_sec
O02863
resolver
uniprot_sec
O02864
resolver
uniprot_sec
O02865
resolver
uniprot_sec
O02866
resolver
uniprot_sec
O02958
resolver
uniprot_sec
O19505
resolver
uniprot_sec
O19652
resolver
uniprot_sec
O19676
resolver
uniprot_sec
O62879
resolver
uniprot_sec
O62882
resolver
uniprot_sec
O62883
resolver
uniprot_sec
O62888
resolver
uniprot_sec
O78060
resolver
uniprot_sec
O78061
resolver
uniprot_sec
O78062
resolver
uniprot_sec
O78063
resolver
uniprot_sec
O78067
resolver
uniprot_sec
O78068
resolver
uniprot_sec
O78069
resolver
uniprot_sec
O78072
resolver
uniprot_sec
O78083
resolver
uniprot_sec
O78090
resolver
uniprot_sec
O78091
resolver
uniprot_sec
O78149
resolver
uniprot_sec
O78165
resolver
uniprot_sec
O78166
resolver
uniprot_sec
O78178
resolver
uniprot_sec
O78202
resolver
uniprot_sec
O78203
resolver
uniprot_sec
O78211
resolver
uniprot_sec
O78214
resolver
uniprot_sec
P04222
resolver
uniprot_sec
P30499
resolver
uniprot_sec
P30500
resolver
uniprot_sec
P30501
resolver
uniprot_sec
P30502
resolver
uniprot_sec
P30503
resolver
uniprot_sec
P30504
resolver
uniprot_sec
P30505
resolver
uniprot_sec
P30506
resolver
uniprot_sec
P30507
resolver
uniprot_sec
P30508
resolver
uniprot_sec
P30509
resolver
uniprot_sec
P30510
resolver
uniprot_sec
P79498
resolver
uniprot_sec
Q07000
resolver
uniprot_sec
Q29631
resolver
uniprot_sec
Q29641
resolver
uniprot_sec
Q29643
resolver
uniprot_sec
Q29652
resolver
uniprot_sec
Q29743
resolver
uniprot_sec
Q29768
resolver
uniprot_sec
Q29862
resolver
uniprot_sec
Q29864
resolver
uniprot_sec
Q29865
resolver
uniprot_sec
Q29867
resolver
uniprot_sec
Q29921
resolver
uniprot_sec
Q29959
resolver
uniprot_sec
Q29960
resolver
uniprot_sec
Q29963
resolver
uniprot_sec
Q29986
resolver
uniprot_sec
Q29989
resolver
uniprot_sec
Q29990
resolver
uniprot_sec
Q29991
resolver
uniprot_sec
Q29992
resolver
uniprot_sec
Q29993
resolver
uniprot_sec
Q30192
resolver
uniprot_sec
Q31605
resolver
uniprot_sec
Q31627
resolver
uniprot_sec
Q860R1
resolver
uniprot_sec
Q860R2
resolver
uniprot_sec
Q95463
resolver
uniprot_sec
Q95603
resolver
uniprot_sec
Q95604
resolver
uniprot_sec
Q99528
resolver
uniprot_sec
Q9BD28
resolver
uniprot_sec
Q9GIK4
resolver
uniprot_sec
Q9GIK8
resolver
uniprot_sec
Q9GJ33
resolver
uniprot_sec
Q9MY30
resolver
uniprot_sec
Q9MY31
resolver
uniprot_sec
Q9MY35
resolver
uniprot_sec
Q9MY49
resolver
uniprot_sec
Q9MY74
resolver
uniprot_sec
Q9MYI3
resolver
uniprot_sec
Q9TNN7
resolver
uniprot_sec
Q9TNZ8
resolver
uniprot_sec
Q9TPS4
resolver
uniprot_sec
Q9TPV8
resolver
uniprot_sec
Q9TPX2
resolver
uniprot_sec
Q9TQB4
resolver
uniprot_sec
Q9TQJ5
resolver
uniprot_sec
Q9TQP9
resolver
uniprot_sec
Q9UM32
resolver
uniprot_sec
Q9UM33
resolver
uniprot_sec
Q9UM42
resolver
uniprot_sec
Q9UQS9
resolver
amino_acid_sequence
MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQLRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEPSSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKGGSCSQAACSNSAQGSDESLITCKA
uniprot
proteins
disease_involvement
DISEASE: Psoriasis 1 (PSORS1) [MIM:177900]: A common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. {ECO:0000269|PubMed:16642438}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry. Allele C*06:02 presents a melanocyte autoantigen ADAMTSL5 (VRSRRCLRL) to Valpha3S1/Vbeta13S1 TCR on CD8-positive T cells, and may trigger an autoimmune response against melanocytes. {ECO:0000269|PubMed:26621454}.
uniprot
proteins
function
FUNCTION: Antigen-presenting major histocompatibility complex class I (MHCI) molecule with an important role in reproduction and antiviral immunity (PubMed:11172028, PubMed:20104487, PubMed:20439706, PubMed:20972337, PubMed:24091323, PubMed:28649982, PubMed:29312307). In complex with B2M/beta 2 microglobulin displays a restricted repertoire of self and viral peptides and acts as a dominant ligand for inhibitory and activating killer immunoglobulin receptors (KIRs) expressed on NK cells (PubMed:16141329). In an allogeneic setting, such as during pregnancy, mediates interaction of extravillous trophoblasts with KIR on uterine NK cells and regulate trophoblast invasion necessary for placentation and overall fetal growth (PubMed:20972337, PubMed:24091323). During viral infection, may present viral peptides with low affinity for KIRs, impeding KIR-mediated inhibition through peptide antagonism and favoring lysis of infected cells (PubMed:20439706). Presents a restricted repertoire of viral peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-C-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected cells, particularly in chronic viral infection settings such as HIV-1 or CMV infection (PubMed:11172028, PubMed:20104487, PubMed:28649982). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (By similarity). Typically presents intracellular peptide antigens of 9 amino acids that arise from cytosolic proteolysis via proteasome. Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9. Preferentially displays peptides having a restricted repertoire of hydrophobic or aromatic amino acids (Phe, Ile, Leu, Met, Val and Tyr) at the C-terminal anchor (PubMed:25311805, PubMed:8265661). {ECO:0000250|UniProtKB:P04439, ECO:0000269|PubMed:11172028, ECO:0000269|PubMed:16141329, ECO:0000269|PubMed:20104487, ECO:0000269|PubMed:20439706, ECO:0000269|PubMed:20972337, ECO:0000269|PubMed:24091323, ECO:0000269|PubMed:25311805, ECO:0000269|PubMed:28649982, ECO:0000269|PubMed:29312307, ECO:0000269|PubMed:8265661}.; FUNCTION: ALLELE C*01:02: The peptide-bound form interacts with KIR2DL2 and KIR2DL3 inhibitory receptors on NK cells. The low affinity peptides compete with the high affinity peptides impeding KIR-mediated inhibition and favoring lysis of infected cells (PubMed:20439706). Presents to CD8-positive T cells a CMV epitope derived from UL83/pp65 (RCPEMISVL), an immediate-early antigen necessary for initiating viral replication (PubMed:12947002). {ECO:0000269|PubMed:12947002, ECO:0000269|PubMed:20439706}.; FUNCTION: ALLELE C*04:01: Presents a conserved HIV-1 epitope derived from env (SFNCGGEFF) to memory CD8-positive T cells, eliciting very strong IFNG responses (PubMed:20104487). Presents CMV epitope derived from UL83/pp65 (QYDPVAALF) to CD8-positive T cells, triggering T cell cytotoxic response (PubMed:12947002). {ECO:0000269|PubMed:12947002, ECO:0000269|PubMed:20104487}.; FUNCTION: ALLELE C*05:01: Presents HIV-1 epitope derived from rev (SAEPVPLQL) to CD8-positive T cells, triggering T cell cytotoxic response. {ECO:0000269|PubMed:11172028}.; FUNCTION: ALLELE C*06:02: In trophoblasts, interacts with KIR2DS2 on uterine NK cells and triggers NK cell activation, including secretion of cytokines such as GMCSF that enhances trophoblast migration. {ECO:0000269|PubMed:24091323}.; FUNCTION: ALLELE C*07:02: Plays an important role in the control of chronic CMV infection. Presents immunodominant CMV epitopes derived from IE1 (LSEFCRVL and CRVLCCYVL) and UL28 (FRCPRRFCF), both antigens synthesized during immediate-early period of viral replication. Elicits a strong anti-viral CD8-positive T cell immune response that increases markedly with age. {ECO:0000269|PubMed:29312307}.; FUNCTION: ALLELE C*08:01: Presents viral epitopes derived from CMV UL83 (VVCAHELVC) and IAV M1 (GILGFVFTL), triggering CD8-positive T cell cytotoxic response. {ECO:0000269|PubMed:12947002, ECO:0000269|PubMed:24990997}.; FUNCTION: ALLELE C*12:02: Presents CMV epitope derived from UL83 (VAFTSHEHF) to CD8-positive T cells. {ECO:0000269|PubMed:12947002}.; FUNCTION: ALLELE C*15:02: Presents CMV epitope derived from UL83 CC (VVCAHELVC) to CD8-positive T cells, triggering T cell cytotoxic response. {ECO:0000269|PubMed:12947002}.
uniprot
proteins
mass_dalton
40649
uniprot
proteins
mutagenesis
MUTAGEN 112; /note="S->G: Impairs N-linked glycosylation resulting in impaired interaction with CANX and CALR chaperones as well as TAPBPL."; /evidence="ECO:0000269|PubMed:18420581
uniprot
proteins
post_translational_modification
PTM: N-linked glycosylation at Asn-110 is required for efficient interaction with CANX and CALR chaperones and appropriate HLA-C-B2M folded conformers prior to peptide loading. {ECO:0000269|PubMed:18420581, ECO:0000269|PubMed:19159218}.
uniprot
proteins
pubmed
10372547
uniprot
proteins
pubmed
10488744
uniprot
proteins
pubmed
10850706
uniprot
proteins
pubmed
11122018
uniprot
proteins
pubmed
11172028
uniprot
proteins
pubmed
11323700
uniprot
proteins
pubmed
11390610
uniprot
proteins
pubmed
12622774
uniprot
proteins
pubmed
12947002
uniprot
proteins
pubmed
1317015
uniprot
proteins
pubmed
1384166
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
1598685
uniprot
proteins
pubmed
16141329
uniprot
proteins
pubmed
16235096
uniprot
proteins
pubmed
16642438
uniprot
proteins
pubmed
1711567
uniprot
proteins
pubmed
18420581
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
20104487
uniprot
proteins
pubmed
20356336
uniprot
proteins
pubmed
20439706
uniprot
proteins
pubmed
20972337
uniprot
proteins
pubmed
24091323
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24990997
uniprot
proteins
pubmed
25311805
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26621454
uniprot
proteins
pubmed
2714852
uniprot
proteins
pubmed
2715640
uniprot
proteins
pubmed
2787363
uniprot
proteins
pubmed
28649982
uniprot
proteins
pubmed
28650991
uniprot
proteins
pubmed
2914713
uniprot
proteins
pubmed
29312307
uniprot
proteins
pubmed
37264229
uniprot
proteins
pubmed
7482492
uniprot
proteins
pubmed
7905471
uniprot
proteins
pubmed
8265661
uniprot
proteins
pubmed
8655361
uniprot
proteins
pubmed
9008313
uniprot
proteins
pubmed
9098935
uniprot
proteins
pubmed
9211742
uniprot
proteins
sequence_length
366
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18420581, ECO:0000269|PubMed:20972337, ECO:0000269|PubMed:28649982}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:18420581}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 309..333; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins