Aebp1
entrez
11568
canonical
uniprot
Q640N1
canonical
ensembl
ENSMUSG00000020473
resolver
ensp
ENSMUSP00000099987
resolver
ensp
ENSMUSP00000326104
resolver
genesymbol
Aebp1
resolver
genesymbol_syn
Aclp
resolver
uniprot
O88442
resolver
uniprot
Q3TVV5
resolver
uniprot
Q3TWA7
resolver
uniprot
Q3TX56
resolver
uniprot
Q3TXB2
resolver
uniprot
Q5NCI9
resolver
uniprot
Q61281
resolver
uniprot_entry
AEBP1_MOUSE
resolver
uniprot_sec
O88442
resolver
uniprot_sec
Q3TVV5
resolver
uniprot_sec
Q3TWA7
resolver
uniprot_sec
Q3TX56
resolver
uniprot_sec
Q3TXB2
resolver
uniprot_sec
Q5NCI9
resolver
uniprot_sec
Q61281
resolver
amino_acid_sequence
MAPVRTASLLCGLLALLTLCPEGNPQTVLTDDEIEEFLEGFLSELETQSPPREDDVEVQPLPEPTQRPRKSKAGGKQRADVEVPPEKNKDKEKKGKKDKGPKATKPLEGSTRPTKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKKPKEKPPKATKRPSAGKKFSTVAPLETLDRLLPSPSNPSAQELPQKRDTPFPNAWQGQGEETQVEAKQPRPEPEEETEMPTLDYNDQIEKEDYEDFEYIRRQKQPRPTPSRRRLWPERPEEKTEEPEERKEVEPPLKPLLPPDYGDSYVIPNYDDLDYYFPHPPPQKPDVGQEVDEEKEEMKKPKKEGSSPKEDTEDKWTVEKNKDHKGPRKGEELEEEWAPVEKIKCPPIGMESHRIEDNQIRASSMLRHGLGAQRGRLNMQAGANEDDYYDGAWCAEDESQTQWIEVDTRRTTRFTGVITQGRDSSIHDDFVTTFFVGFSNDSQTWVMYTNGYEEMTFYGNVDKDTPVLSELPEPVVARFIRIYPLTWNGSLCMRLEVLGCPVTPVYSYYAQNEVVTTDSLDFRHHSYKDMRQLMKAVNEECPTITRTYSLGKSSRGLKIYAMEISDNPGDHELGEPEFRYTAGIHGNEVLGRELLLLLMQYLCQEYRDGNPRVRNLVQDTRIHLVPSLNPDGYEVAAQMGSEFGNWALGLWTEEGFDIFEDFPDLNSVLWAAEEKKWVPYRVPNNNLPIPERYLSPDATVSTEVRAIISWMEKNPFVLGANLNGGERLVSYPYDMARTPSQEQLLAEALAAARGEDDDGVSEAQETPDHAIFRWLAISFASAHLTMTEPYRGGCQAQDYTSGMGIVNGAKWNPRSGTFNDFSYLHTNCLELSVYLGCDKFPHESELPREWENNKEALLTFMEQVHRGIKGVVTDEQGIPIANATISVSGINHGVKTASGGDYWRILNPGEYRVTAHAEGYTSSAKICNVDYDIGATQCNFILARSNWKRIREILAMNGNRPILRVDPSRPMTPQQRRMQQRRLQYRLRMREQMRLRRLNSTAGPATSPTPALMPPPSPTPAITLRPWEVLPTTTAGWEESETETYTEVVTEFETEYGTDLEVEEIEEEEEEEEEEMDTGLTFPLTTVETYTVNFGDF
uniprot
proteins
function
FUNCTION: [Isoform 1]: As a positive regulator of collagen fibrillogenesis, it is probably involved in the organization and remodeling of the extracellular matrix. {ECO:0000250|UniProtKB:Q8IUX7}.; FUNCTION: [Isoform 2]: May positively regulate MAP-kinase activity in adipocytes, leading to enhanced adipocyte proliferation and reduced adipocyte differentiation. May also positively regulate NF-kappa-B activity in macrophages by promoting the phosphorylation and subsequent degradation of I-kappa-B-alpha (NFKBIA), leading to enhanced macrophage inflammatory responsiveness. Can act as a transcriptional repressor. {ECO:0000269|PubMed:10406805, ECO:0000269|PubMed:11152475, ECO:0000269|PubMed:11438679, ECO:0000269|PubMed:14729459, ECO:0000269|PubMed:16307171, ECO:0000269|PubMed:16461908, ECO:0000269|PubMed:16538615, ECO:0000269|PubMed:17202411, ECO:0000269|PubMed:7477299}.
uniprot
proteins
mass_dalton
128365
uniprot
proteins
mutagenesis
MUTAGEN 1003; /note="T->A: Impairs DNA-binding and phosphorylation by MAPK1."; /evidence="ECO:0000269|PubMed:15654748"; MUTAGEN 1003; /note="T->D: Impairs DNA-binding."; /evidence="ECO:0000269|PubMed:15654748
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MAPK1 in vitro. {ECO:0000269|PubMed:15654748}.
uniprot
proteins
protein_family
Peptidase M14 family
uniprot
proteins
pubmed
10406805
uniprot
proteins
pubmed
11152475
uniprot
proteins
pubmed
11438679
uniprot
proteins
pubmed
11738825
uniprot
proteins
pubmed
12072377
uniprot
proteins
pubmed
14729459
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15654748
uniprot
proteins
pubmed
15749083
uniprot
proteins
pubmed
15927179
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16307171
uniprot
proteins
pubmed
16461908
uniprot
proteins
pubmed
16538615
uniprot
proteins
pubmed
17202411
uniprot
proteins
pubmed
17299101
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
7477299
uniprot
proteins
pubmed
8920928
uniprot
proteins
pubmed
9624159
uniprot
proteins
sequence_length
1128
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Secreted {ECO:0000269|PubMed:11438679, ECO:0000269|PubMed:15927179}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:17202411, ECO:0000269|PubMed:9624159}. Nucleus {ECO:0000269|PubMed:17202411}.
uniprot
proteins