Pabpc1
entrez
171350
canonical
uniprot
Q9EPH8
canonical
ensembl
ENSRNOG00000008639
resolver
ensembl
ENSRNOG00055023445
resolver
ensembl
ENSRNOG00060008612
resolver
ensembl
ENSRNOG00065003631
resolver
ensp
ENSRNOP00000012775
resolver
ensp
ENSRNOP00055032754
resolver
ensp
ENSRNOP00060011047
resolver
ensp
ENSRNOP00065003799
resolver
enst
ENSRNOT00000012775
resolver
enst
ENSRNOT00055040315
resolver
enst
ENSRNOT00060014378
resolver
enst
ENSRNOT00065005267
resolver
genesymbol
Pabpc1
resolver
genesymbol_syn
Pabp1
resolver
uniprot_entry
PABP1_RAT
resolver
amino_acid_sequence
MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQQPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFSAFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKEREAELGARAKEFTNVYIKNFGEDMDDERLKELFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKNLDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRAAYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQRVANTSTQTMGPRPAAAATAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPSLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV
uniprot
proteins
function
FUNCTION: Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed. By binding to long poly(A) tails, may protect them from uridylation by ZCCHC6/ZCCHC11 and hence contribute to mRNA stability. {ECO:0000250|UniProtKB:P11940}.
uniprot
proteins
mass_dalton
70701
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MAPKAPK2. {ECO:0000250|UniProtKB:P11940}.; PTM: Methylated by CARM1. Arg-493 is dimethylated, probably to asymmetric dimethylarginine (By similarity). {ECO:0000250|UniProtKB:P11940}.
uniprot
proteins
protein_family
Polyadenylate-binding protein type-1 family
uniprot
proteins
pubmed
11416190
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
636
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P11940}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:P11940}. Nucleus {ECO:0000250|UniProtKB:P11940}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P11940}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs (By similarity). Shuttles between the cytoplasm and the nucleus (By similarity). During stress and in the absence of DDX3X, localizes to the nucleus (By similarity). At the leading edge of migrating fibroblasts, colocalizes with DDX3X (By similarity). Relocalizes to cytoplasmic stress granules upon cellular stress where it colocalizes with ENDOV (By similarity). {ECO:0000250|UniProtKB:P11940}.
uniprot
proteins