Cidea
entrez
12683
canonical
uniprot
O70302
canonical
ensembl
ENSMUSG00000024526
resolver
ensp
ENSMUSP00000025404
resolver
enst
ENSMUST00000025404
resolver
genesymbol
Cidea
resolver
uniprot
Q4V9X2
resolver
uniprot_entry
CIDEA_MOUSE
resolver
uniprot_sec
Q4V9X2
resolver
amino_acid_sequence
METARDYAGALIRPLTFMGLQTKKVLLTPLIHPARPFRVSNHDRSSRRGVMASSLQELISKTLDVLVITTGLVTLVLEEDGTVVDTEEFFQTLRDNTHFMILEKGQKWTPGSKYVPVCKQPKKSGIARVTFDLYRLNPKDFLGCLNVKATMYEMYSVSYDIRCTSFKAVLRNLLRFMSYAAQMTGQFLVYAGTYMLRVLGDTEEQPSPKPSTKGWFM
uniprot
proteins
function
FUNCTION: Lipid transferase that promotes unilocular lipid droplet formation by mediating lipid droplet fusion (PubMed:18509062, PubMed:22144693, PubMed:26609809, PubMed:36477540). Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage (PubMed:18509062, PubMed:22144693, PubMed:26609809). Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (PubMed:18509062, PubMed:22144693, PubMed:26609809). The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC (PubMed:18509062, PubMed:22144693). May also act as a CEBPB coactivator in epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein (PubMed:22245780). By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (PubMed:22245780). When overexpressed, induces apoptosis; the physiological significance of its role in apoptosis is unclear (PubMed:9564035). {ECO:0000269|PubMed:18509062, ECO:0000269|PubMed:22144693, ECO:0000269|PubMed:22245780, ECO:0000269|PubMed:26609809, ECO:0000269|PubMed:36477540, ECO:0000269|PubMed:9564035}.
uniprot
proteins
mass_dalton
24669
uniprot
proteins
mutagenesis
MUTAGEN 23; /note="K->A: Substantial reduction in nuclear localization and loss of XDH induction; when associated with A-24."; /evidence="ECO:0000269|PubMed:22245780"; MUTAGEN 23; /note="K->R: Increased nuclear localization."; /evidence="ECO:0000269|PubMed:22245780"; MUTAGEN 24; /note="K->A: Substantial reduction in nuclear localization and loss of XDH induction; when associated with A-23."; /evidence="ECO:0000269|PubMed:22245780"; MUTAGEN 166..170; /note="FKAVL->RAVRR: Abolished localization to lipid droplets."; /evidence="ECO:0000269|PubMed:26609809"; MUTAGEN 166..169; /note="FKAV->RKRR: Abolished localization to lipid droplets."; /evidence="ECO:0000269|PubMed:26609809"; MUTAGEN 167..175; /note="KAVLRNLLR->EAVLENLLE: Does not affect localization to lipid droplets but prevents lipid droplet fusion."; /evidence="ECO:0000269|PubMed:26609809"; MUTAGEN 167..175; /note="KAVLRNLLR->HAVLHNLLH: Does not affect localization to lipid droplets or ability to mediate lipid droplet fusion."; /evidence="ECO:0000269|PubMed:26609809"; MUTAGEN 171..175; /note="RNLLR->ANLLA: Abolished lipid transferase activity."; /evidence="ECO:0000269|PubMed:26609809
uniprot
proteins
protein_family
CIDE family
uniprot
proteins
pubmed
12910269
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18509062
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20810722
uniprot
proteins
pubmed
22144693
uniprot
proteins
pubmed
22245780
uniprot
proteins
pubmed
26609809
uniprot
proteins
pubmed
26733203
uniprot
proteins
pubmed
36477540
uniprot
proteins
pubmed
9564035
uniprot
proteins
sequence_length
217
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lipid droplet {ECO:0000269|PubMed:18509062, ECO:0000269|PubMed:20810722, ECO:0000269|PubMed:22144693, ECO:0000269|PubMed:26609809}. Nucleus {ECO:0000269|PubMed:22245780}. Note=Enriched at lipid droplet contact sites (PubMed:18509062, PubMed:22144693). Using a GFP-tagged construct, has been shown to localize to mitochondria, where it could interact with UCP1 and hence inhibit UCP1 uncoupling activity (PubMed:12910269). These data could not be confirmed (PubMed:18509062, PubMed:22245780). {ECO:0000269|PubMed:12910269, ECO:0000269|PubMed:18509062, ECO:0000269|PubMed:22144693, ECO:0000269|PubMed:22245780}.
uniprot
proteins