Atcay
entrez
362826
canonical
uniprot
Q1M168
canonical
ensembl
ENSRNOG00000020407
resolver
ensembl
ENSRNOG00065021983
resolver
ensp
ENSRNOP00000045560
resolver
ensp
ENSRNOP00065030230
resolver
enst
ENSRNOT00000041325
resolver
enst
ENSRNOT00065037433
resolver
genesymbol
Atcay
resolver
uniprot_entry
ATCAY_RAT
resolver
amino_acid_sequence
MGTTEATLRMENVDVRDEWQDEDLPRPLPEDTGEDHLGGTVEDSSSPPSTLNLSGAHRKRKTLVAPEINISLDQSEGSLLSDDFLDTPDDLDINVDDIETPDETDSLEFLGNGNELEWEDDTPVATAKNMPGDSADLFGDGSGEDGSAANGRLWRTVIIGEQEHRIDLHMIRPYMKVVTHGGYYGEGLNAIIVFAACFLPDSSSPDYHYIMENLFLYVISSLELLVAEDYMIVYLNGATPRRRMPGIGWLKKCYHMIDRRLRKNLKSLIIVHPSWFIRTVLAISRPFISVKFISKIQYVHSLEELEQLIPMEHVQLPACVLQYEEQRLRAKRESARPPQPEFLLPRSEEKPETVEEEDRAAEVTEDQETSMS
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Atcay are the cause of primary generalized dystonia. The dt (SD-dt:JFL) rat is a spontaneous mutant that develops a dystonic motor syndrome by P12. Dystonic rats exhibit both axial and appendicular dystonia that progresses in severity with increasing postnatal age. There are no gross differences between normal and dt rats in terms of brain morphology. {ECO:0000269|PubMed:16246457}.
uniprot
proteins
function
FUNCTION: Functions in the development of neural tissues, particularly the postnatal maturation of the cerebellar cortex. May play a role in neurotransmission through regulation of glutaminase/GLS, an enzyme responsible for the production in neurons of the glutamate neurotransmitter. Alternatively, may regulate the localization of mitochondria within axons and dendrites. {ECO:0000269|PubMed:16246457, ECO:0000269|PubMed:19861499}.
uniprot
proteins
mass_dalton
42117
uniprot
proteins
post_translational_modification
PTM: Cleaved by CASP3 and CASP7. The potential C-terminal product released by CASP3 cleavage may inhibit the ERK signaling pathway through MAP2K2 (By similarity). {ECO:0000250}.; PTM: May be ubiquitinated by STUB1. {ECO:0000250}.
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16246457
uniprot
proteins
pubmed
16899818
uniprot
proteins
pubmed
19861499
uniprot
proteins
sequence_length
372
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, axon {ECO:0000269|PubMed:19861499}. Cell projection, dendrite {ECO:0000269|PubMed:19861499}. Presynapse {ECO:0000269|PubMed:19861499}. Mitochondrion {ECO:0000269|PubMed:19861499}. Cell projection, growth cone {ECO:0000269|PubMed:19861499}. Cytoplasm {ECO:0000250|UniProtKB:Q86WG3}.
uniprot
proteins