ATRIP
entrez
84126
canonical
uniprot
Q8WXE1
canonical
ensembl
ENSG00000164053
resolver
ensp
ENSP00000302338
resolver
ensp
ENSP00000323099
resolver
ensp
ENSP00000400930
resolver
ensp
ENSP00000489041
resolver
genesymbol
ATRIP
resolver
genesymbol_syn
AGS1
resolver
hgnc
HGNC:33499
resolver
uniprot
A8K6A3
resolver
uniprot
A8K714
resolver
uniprot
B2RCE7
resolver
uniprot
B4DU92
resolver
uniprot
B5MEB7
resolver
uniprot
Q69YK9
resolver
uniprot
Q8NHQ2
resolver
uniprot
Q8WUG7
resolver
uniprot
Q96CL3
resolver
uniprot
Q9HA30
resolver
uniprot_entry
ATRIP_HUMAN
resolver
uniprot_sec
A8K6A3
resolver
uniprot_sec
A8K714
resolver
uniprot_sec
B2RCE7
resolver
uniprot_sec
B4DU92
resolver
uniprot_sec
B5MEB7
resolver
uniprot_sec
Q69YK9
resolver
uniprot_sec
Q8NHQ2
resolver
uniprot_sec
Q8WUG7
resolver
uniprot_sec
Q96CL3
resolver
uniprot_sec
Q9HA30
resolver
amino_acid_sequence
MAGTSAPGSKRRSEPPAPRPGPPPGTGHPPSKRARGFSAAAAPDPDDPFGAHGDFTADDLEELDTLASQALSQCPAAARDVSSDHKVHRLLDGMSKNPSGKNRETVPIKDNFELEVLQAQYKELKEKMKVMEEEVLIKNGEIKILRDSLHQTESVLEEQRRSHFLLEQEKTQALSDKEKEFSKKLQSLQSELQFKDAEMNELRTKLQTSERANKLAAPSVSHVSPRKNPSVVIKPEACSPQFGKTSFPTKESFSANMSLPHPCQTESGYKPLVGREDSKPHSLRGDSIKQEEAQKSFVDSWRQRSNTQGSILINLLLKQPLIPGSSLSLCHLLSSSSESPAGTPLQPPGFGSTLAGMSGLRTTGSYDGSFSLSALREAQNLAFTGLNLVARNECSRDGDPAEGGRRAFPLCQLPGAVHFLPLVQFFIGLHCQALQDLAAAKRSGAPGDSPTHSSCVSSGVETNPEDSVCILEGFSVTALSILQHLVCHSGAVVSLLLSGVGADSAAGEGNRSLVHRLSDGDMTSALRGVADDQGQHPLLKMLLHLLAFSSAATGHLQASVLTQCLKVLVKLAENTSCDFLPRFQCVFQVLPKCLSPETPLPSVLLAVELLSLLADHDQLAPQLCSHSEGCLLLLLYMYITSRPDRVALETQWLQLEQEVVWLLAKLGVQSPLPPVTGSNCQCNVEVVRALTVMLHRQWLTVRRAGGPPRTDQQRRTVRCLRDTVLLLHGLSQKDKLFMMHCVEVLHQFDQVMPGVSMLIRGLPDVTDCEEAALDDLCAAETDVEDPEVECG
uniprot
proteins
function
FUNCTION: Required for checkpoint signaling after DNA damage. Required for ATR expression, possibly by stabilizing the protein. {ECO:0000269|PubMed:12791985}.
uniprot
proteins
mass_dalton
85838
uniprot
proteins
mutagenesis
MUTAGEN 769..770; /note="EE->AA: Abolishes interaction with ATR and its recruitment to sites of DNA damage."; /evidence="ECO:0000269|PubMed:15758953"; MUTAGEN 774..775; /note="DD->AA: Abolishes interaction with ATR and its recruitment to sites of DNA damage."; /evidence="ECO:0000269|PubMed:15758953
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by ATR. {ECO:0000269|PubMed:11721054}.
uniprot
proteins
protein_family
ATRIP family
uniprot
proteins
pubmed
11721054
uniprot
proteins
pubmed
12791985
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15758953
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18283122
uniprot
proteins
pubmed
19889979
uniprot
proteins
sequence_length
791
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11721054, ECO:0000269|PubMed:18283122}. Note=Redistributes to discrete nuclear foci upon DNA damage.
uniprot
proteins