TU3A
entrez
11170
canonical
uniprot
O95990
canonical
ensembl
ENSG00000168309
resolver
ensp
ENSP00000354270
resolver
ensp
ENSP00000377991
resolver
ensp
ENSP00000400858
resolver
ensp
ENSP00000419124
resolver
ensp
ENSP00000538044
resolver
genesymbol
FAM107A
resolver
genesymbol
TU3A
resolver
genesymbol_syn
DRR1
resolver
genesymbol_syn
FAM107A
resolver
genesymbol_syn
TU3A
resolver
hgnc
HGNC:30827
resolver
uniprot
B3KNQ4
resolver
uniprot
B7ZAY5
resolver
uniprot
J3KR61
resolver
uniprot
Q6IAM1
resolver
uniprot
Q96NH4
resolver
uniprot_entry
F107A_HUMAN
resolver
uniprot_entry
Q6IAM1_HUMAN
resolver
uniprot_sec
B3KNQ4
resolver
uniprot_sec
B7ZAY5
resolver
uniprot_sec
J3KR61
resolver
uniprot_sec
Q96NH4
resolver
amino_acid_sequence
MYSEIQRERADIGGLMARPEYREWNPELIKPKKLLNPVKASRSHQELHRELLMNHRRGLGVDSKPELQRVLEHRRRNQLIKKKKEELEAKRLQCPFEQELLRRQQRLNQLEKPPEKEEDHAPEFIKVRENLRRIATLTSEEREL
uniprot
proteins
function
FUNCTION: Stress-inducible actin-binding protein that plays a role in synaptic and cognitive functions by modulating actin filamentous (F-actin) dynamics. Mediates polymerization of globular actin to F-actin. Also binds to, stabilizes and bundles F-actin. Involved in synaptic function by regulating neurite outgrowth in an actin-dependent manner and for the acquisition of hippocampus-dependent cognitive function, such as learning and long-term memory (By similarity). Plays a role in the actin and microtubule cytoskeleton organization; negatively regulates focal adhesion (FA) assembly promoting malignant glial cell migration in an actin-, microtubule- and MAP1A-dependent manner (PubMed:20543869). Also involved in neuroblastoma G1/S phase cell cycle progression and cell proliferation inhibition by stimulating ubiquitination of NF-kappa-B subunit RELA and NF-kappa-B degradation in a COMMD1- and actin-dependent manner (PubMed:10564580, PubMed:28604741). May play a role in tumor development (PubMed:10564580). {ECO:0000250|UniProtKB:Q78TU8, ECO:0000269|PubMed:10564580, ECO:0000269|PubMed:20543869, ECO:0000269|PubMed:28604741}.
uniprot
proteins
mass_dalton
17455
uniprot
proteins
mutagenesis
MUTAGEN 48..50; /note="Missing: Increases nuclear and diffused cytoplasm localization, decreases interaction with MAP1A, alters actin cytoskeleton organization and decreases focal adhesion (FA) disassembly and cell migration."; /evidence="ECO:0000269|PubMed:20543869"; MUTAGEN 65..66; /note="PE->AA: Increases diffused cytoplasm localization, loss of interaction with ACTB and colocalization with nuclear F-actin, decreases COMMD1 protein stability and ubiquitination of NF-kappa-B subunit RELA and decreases focal adhesion (FA) disassembly and cell migration; when associated with 122-A-A-123."; /evidence="ECO:0000269|PubMed:28604741"; MUTAGEN 74..76; /note="RRR->AAA: Decreases nuclear localization and ubiquitination of NF-kappa-B subunit RELA."; /evidence="ECO:0000269|PubMed:28604741"; MUTAGEN 81..84; /note="KKKK->AAAA: Decreases nuclear localization."; /evidence="ECO:0000269|PubMed:28604741"; MUTAGEN 122..123; /note="PE->AA: Increases diffused cytoplasm localization, loss of interaction with ACTB and colocalization with nuclear F-actin, decreases COMMD1 protein stability and ubiquitination of NF-kappa-B subunit RELA and decreases focal adhesion (FA) disassembly and cell migration; when associated with 65-A-A-66."; /evidence="ECO:0000269|PubMed:28604741
uniprot
proteins
protein_family
FAM107 family
uniprot
proteins
pubmed
10564580
uniprot
proteins
pubmed
10702698
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
11256614
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
20543869
uniprot
proteins
pubmed
21969592
uniprot
proteins
pubmed
28604741
uniprot
proteins
sequence_length
144
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10564580, ECO:0000269|PubMed:11256614, ECO:0000269|PubMed:20543869, ECO:0000269|PubMed:28604741}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:20543869, ECO:0000269|PubMed:28604741}. Cell junction, focal adhesion {ECO:0000269|PubMed:20543869}. Cell projection, ruffle membrane {ECO:0000269|PubMed:20543869}. Synapse {ECO:0000250|UniProtKB:Q78TU8}. Note=Colocalizes with F-actin and COMMD1 in the nucleus (PubMed:28604741). Colocalizes with MAP1A along actin stress fibers and membrane ruffles (PubMed:20543869). {ECO:0000269|PubMed:20543869, ECO:0000269|PubMed:28604741}.
uniprot
proteins