Slc9a6
entrez
236794
canonical
uniprot
A1L3P4
canonical
ensembl
ENSMUSG00000060681
resolver
ensp
ENSMUSP00000076922
resolver
enst
ENSMUST00000077741
resolver
genesymbol
Slc9a6
resolver
genesymbol_syn
Nhe6
resolver
uniprot
Q8BTG0
resolver
uniprot_entry
SL9A6_MOUSE
resolver
uniprot_sec
Q8BTG0
resolver
amino_acid_sequence
MAGARRGWRLAPVRRGVCGPRARPLMRPLWLLFAVSFFGWTGALDGSGGTTRAMDEEIVSEKQAEESHRQDSANLLIFILLLTLTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTLLVNVSGKFYEYTLKGEISSHELNNVQDNEMLRKVTFDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTALVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFNPTFVVGAFIAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDTATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPDNERRTTKAESAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSDLILNDGDISLTYGDSTVNTESATASAPRRFMGNSSEDALDRELTFGDHELVIRGTRLVLPMDDSEPALNSLDDTRHSPA
uniprot
proteins
function
FUNCTION: Endosomal Na(+), K(+)/H(+) antiporter. Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+). By facilitating proton efflux, SLC9A6 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Responsible for alkalizing and maintaining the endosomal pH, and consequently in, e.g., endosome maturation and trafficking of recycling endosomal cargo (PubMed:17005858, PubMed:21413028, PubMed:24035762, PubMed:34526390). Plays a critical role during neurodevelopment by regulating synaptic development and plasticity (PubMed:21413028, PubMed:34526390). Implicated in the maintenance of cell polarity in a manner that is dependent on its ability to modulate intravesicular pH (By similarity). Regulates intracellular pH in some specialized cells, osteoclasts and stereocilia where this transporter localizes to the plasma membrane (PubMed:17005858, PubMed:21413028). {ECO:0000250|UniProtKB:Q92581, ECO:0000269|PubMed:17005858, ECO:0000269|PubMed:21413028, ECO:0000269|PubMed:24035762, ECO:0000269|PubMed:34526390}.
uniprot
proteins
mass_dalton
77953
uniprot
proteins
mutagenesis
MUTAGEN 11; /note="A->S: Mice have normal brain size at 6 months of age and do not show cerebellar degeneration or defective neuronal arborization. Neurons from male mice also do not demonstrate an abnormality in intraendosomal pH compared with controls."; /evidence="ECO:0000269|PubMed:31676550
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated (in vitro). {ECO:0000250|UniProtKB:Q92581}.; PTM: Glycosylated. {ECO:0000250|UniProtKB:Q92581}.
uniprot
proteins
protein_family
Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17005858
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21413028
uniprot
proteins
pubmed
23303939
uniprot
proteins
pubmed
24035762
uniprot
proteins
pubmed
31676550
uniprot
proteins
pubmed
34526390
uniprot
proteins
sequence_length
702
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:Q92581}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000269|PubMed:23303939, ECO:0000269|PubMed:24035762}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:23303939, ECO:0000269|PubMed:24035762}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:24035762}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:17005858}; Multi-pass membrane protein {ECO:0000255}. Note=Present predominantly in the recycling compartments including early and recycling endosomes, but undergoes plasma membrane localization during vesicular recycling, which is enhanced upon certain stimuli, such as hypoxia. {ECO:0000250|UniProtKB:Q92581}.
uniprot
proteins
transmembrane_region
TRANSMEM 72..92; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 104..124; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 177..197; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 212..232; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 253..273; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 279..299; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 325..345; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 373..393; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 415..435; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 437..457; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 480..500; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 516..536; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins