Socs1
entrez
12703
canonical
uniprot
O35716
canonical
ensembl
ENSMUSG00000038037
resolver
ensp
ENSMUSP00000038121
resolver
ensp
ENSMUSP00000155530
resolver
enst
ENSMUST00000038099
resolver
enst
ENSMUST00000229866
resolver
genesymbol
Socs1
resolver
genesymbol_syn
Cish1
resolver
genesymbol_syn
Ssi1
resolver
uniprot
A2RT46
resolver
uniprot
O35960
resolver
uniprot
Q3U3L0
resolver
uniprot_entry
SOCS1_MOUSE
resolver
uniprot_sec
A2RT46
resolver
uniprot_sec
O35960
resolver
uniprot_sec
Q3U3L0
resolver
amino_acid_sequence
MVARNQVAADNAISPAAEPRRRSEPSSSSSSSSPAAPVRPRPCPAVPAPAPGDTHFRTFRSHSDYRRITRTSALLDACGFYWGPLSVHGAHERLRAEPVGTFLVRDSRQRNCFFALSVKMASGPTSIRVHFQAGRFHLDGSRETFDCLFELLEHYVAAPRRMLGAPLRQRRVRPLQELCRQRIVAAVGRENLARIPLNPVLRDYLSSFPFQI
uniprot
proteins
function
FUNCTION: Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF) (PubMed:10064597, PubMed:15169905, PubMed:15522878, PubMed:9202125). Down-regulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity (PubMed:10064597, PubMed:15522878, PubMed:9202125). In vitro, suppresses Tec protein-tyrosine activity (By similarity). Regulates IFN-gamma (IFNG)-mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). {ECO:0000250|UniProtKB:O15524, ECO:0000269|PubMed:10064597, ECO:0000269|PubMed:15169905, ECO:0000269|PubMed:15522878, ECO:0000269|PubMed:9202125}.
uniprot
proteins
mass_dalton
23715
uniprot
proteins
mutagenesis
MUTAGEN 51; /note="P->A: No effect on LIF signal transduction suppression."; MUTAGEN 52; /note="G->A: No effect on LIF signal transduction suppression."; MUTAGEN 53; /note="D->A,R: No effect on LIF signal transduction suppression."; MUTAGEN 54; /note="T->A: No effect on LIF signal transduction suppression."; MUTAGEN 55; /note="H->A,D: No effect on JAK signal transduction suppression."; /evidence="ECO:0000269|PubMed:10064597"; MUTAGEN 56; /note="F->A,S,D: Loss of JAK signal transduction suppression."; /evidence="ECO:0000269|PubMed:10064597"; MUTAGEN 56; /note="F->E,S: Reduced binding to JH1."; /evidence="ECO:0000269|PubMed:10064597"; MUTAGEN 56; /note="F->L: No effect on JAK signal transduction inhibition nor on binding to JH1."; /evidence="ECO:0000269|PubMed:10064597"; MUTAGEN 57; /note="R->A,E: No effect on JAK signal transduction suppression."; /evidence="ECO:0000269|PubMed:10064597"; MUTAGEN 58; /note="T->A: No effect on JAK signal transduction suppression."; /evidence="ECO:0000269|PubMed:10064597"; MUTAGEN 59; /note="F->A,E: Loss of JAK signal transduction suppression. Reduced binding to JH1."; /evidence="ECO:0000269|PubMed:10064597, ECO:0000269|PubMed:11522790"; MUTAGEN 59; /note="F->D: Loss of JAK signal transduction suppression. Destabilization of SOCS1."; /evidence="ECO:0000269|PubMed:10064597, ECO:0000269|PubMed:11522790"; MUTAGEN 59; /note="F->L: No effect on JAK signal transduction suppression nor on binding to JH1."; /evidence="ECO:0000269|PubMed:10064597, ECO:0000269|PubMed:11522790"; MUTAGEN 60; /note="R->A: No effect on LIF signal transduction suppression."; /evidence="ECO:0000269|PubMed:10064597"; MUTAGEN 61; /note="S->E: No effect on JAK signal transduction suppression."; /evidence="ECO:0000269|PubMed:10064597"; MUTAGEN 62; /note="H->E: No effect on JAK signal transduction suppression."; /evidence="ECO:0000269|PubMed:10064597"; MUTAGEN 64; /note="D->R: Loss of JAK signal transduction suppression. Reduced binding to JH1."; /evidence="ECO:0000269|PubMed:10064597"; MUTAGEN 65; /note="Y->A: Some loss of JAK signal transduction signaling. Reduced binding to JH1."; /evidence="ECO:0000269|PubMed:10064597"; MUTAGEN 68; /note="I->E: Loss of binding to JH1/Y-1007 of JAK2 and loss of signal transduction suppression."; MUTAGEN 70; /note="R->E: No effect on LIF signal transduction suppression."; MUTAGEN 75; /note="L->E: Loss of binding to JH1/Y-1007 of JAK2 and loss of signal transduction suppression."; MUTAGEN 105; /note="R->K: Loss of LIF signal transduction suppression. Loss of binding to KIT. No effect on binding to VAV."; /evidence="ECO:0000269|PubMed:10064597"; MUTAGEN 105; /note="R->Q: Loss of IL-6 signal transduction suppression. No effect on binding to TYK2."; /evidence="ECO:0000269|PubMed:10064597"; MUTAGEN 175; /note="L->P: Abolishes interaction with elongin BC complex; when associated with F-179."; /evidence="ECO:0000269|PubMed:9869640"; MUTAGEN 179; /note="C->F: Abolishes interaction with elongin BC complex; when associated with P-175."; /evidence="ECO:0000269|PubMed:9869640
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
SOCS1 family
uniprot
proteins
pubmed
10022833
uniprot
proteins
pubmed
10051596
uniprot
proteins
pubmed
10064597
uniprot
proteins
pubmed
10764816
uniprot
proteins
pubmed
11522790
uniprot
proteins
pubmed
12163497
uniprot
proteins
pubmed
12242343
uniprot
proteins
pubmed
15169905
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15522878
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
24880459
uniprot
proteins
pubmed
9202125
uniprot
proteins
pubmed
9202126
uniprot
proteins
pubmed
9202127
uniprot
proteins
pubmed
9789053
uniprot
proteins
pubmed
9826711
uniprot
proteins
pubmed
9869640
uniprot
proteins
pubmed
9889194
uniprot
proteins
sequence_length
212
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O15524}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:O15524}. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3. {ECO:0000250|UniProtKB:O15524}.
uniprot
proteins