Rtf2
entrez
66404
canonical
uniprot
Q99K95
canonical
ensembl
ENSMUSG00000027502
resolver
ensp
ENSMUSP00000029005
resolver
enst
ENSMUST00000029005
resolver
genesymbol
Rtf2
resolver
genesymbol_syn
Rtfdc1
resolver
uniprot
A2APA0
resolver
uniprot
Q543D3
resolver
uniprot
Q80X88
resolver
uniprot
Q9CV27
resolver
uniprot_entry
RTF2_MOUSE
resolver
uniprot_sec
A2APA0
resolver
uniprot_sec
Q543D3
resolver
uniprot_sec
Q80X88
resolver
uniprot_sec
Q9CV27
resolver
amino_acid_sequence
MGCDGGTIPKRHELVKGPKKVEKVDKDAELVAQWNYCTLSQEILRRPIVACELGRLYNKDAVIEFLLDKSAEKALGKAASHIRSIKNVTELRLSDNPAWEGDKGNTKGDKHDDLQRARFICPVVGLEMNGRHRFCFLRCCGCVFSERALKEIKAEVCHTCGAAFQEEDIIVLNGTKEDVEMLKKRMEERRLRAKLEKKTKKPKTATECASKPGTTQDSAGPSKVKSGKPEEADPDPREKKSTPAPRGAATNGSASGKVGKPPCGALKRSIADSEESETYKSIFTSHSSAKRSKEESAHWVTHTSYCF
uniprot
proteins
function
FUNCTION: Replication termination factor which is a component of the elongating replisome. Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion. Interacts with nascent DNA. {ECO:0000250|UniProtKB:Q9BY42}.
uniprot
proteins
mass_dalton
33935
uniprot
proteins
post_translational_modification
PTM: Undergoes proteasomal degradation, via DDI1 and DDI2. Removal from stalled replisomes and degradation are required for genome stability. {ECO:0000250|UniProtKB:Q9BY42}.
uniprot
proteins
protein_family
Rtf2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
307
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q9BY42}. Note=Localizes at the replication fork. {ECO:0000250|UniProtKB:Q9BY42}.
uniprot
proteins