PAK1IP1
entrez
55003
canonical
uniprot
Q9NWT1
canonical
ensembl
ENSG00000111845
resolver
ensembl
ENSG00000285226
resolver
ensp
ENSP00000368887
resolver
ensp
ENSP00000496482
resolver
ensp
ENSP00000566279
resolver
enst
ENST00000379568
resolver
enst
ENST00000644756
resolver
genesymbol
PAK1IP1
resolver
genesymbol_syn
PIP1
resolver
genesymbol_syn
WDR84
resolver
hgnc
HGNC:20882
resolver
uniprot
A0A0S2Z5C3
resolver
uniprot
Q5T4J2
resolver
uniprot
Q96QJ8
resolver
uniprot
Q96T87
resolver
uniprot_entry
A0A0S2Z5C3_HUMAN
resolver
uniprot_entry
PK1IP_HUMAN
resolver
uniprot_sec
Q5T4J2
resolver
uniprot_sec
Q96QJ8
resolver
uniprot_sec
Q96T87
resolver
amino_acid_sequence
MELVAGCYEQVLFGFAVHPEPEACGDHEQWTLVADFTHHAHTASLSAVAVNSRFVVTGSKDETIHIYDMKKKIEHGALVHHSGTITCLKFYGNRHLISGAEDGLICIWDAKKWECLKSIKAHKGQVTFLSIHPSGKLALSVGTDKTLRTWNLVEGRSAFIKNIKQNAHIVEWSPRGEQYVVIIQNKIDIYQLDTASISGTITNEKRISSVKFLSESVLAVAGDEEVIRFFDCDSLVCLCEFKAHENRVKDMFSFEIPEHHVIVSASSDGFIKMWKLKQDKKVPPSLLCEINTNARLTCLGVWLDKVADMKESLPPAAEPSPVSKEQSKIGKKEPGDTVHKEEKRSKPNTKKRGLTGDSKKATKESGLISTKKRKMVEMLEKKRKKKKIKTMQ
uniprot
proteins
function
FUNCTION: Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly (PubMed:24120868). {ECO:0000269|PubMed:11371639, ECO:0000269|PubMed:24120868}.
uniprot
proteins
mass_dalton
43964
uniprot
proteins
pubmed
11371639
uniprot
proteins
pubmed
12429849
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24120868
uniprot
proteins
sequence_length
392
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
uniprot
proteins