Opn1mw
entrez
14539
canonical
uniprot
O35599
canonical
ensembl
ENSMUSG00000031394
resolver
ensp
ENSMUSP00000033771
resolver
enst
ENSMUST00000033771
resolver
genesymbol
Opn1mw
resolver
genesymbol_syn
Gcp
resolver
uniprot
Q3UEX0
resolver
uniprot
Q548Z4
resolver
uniprot_entry
OPSG_MOUSE
resolver
uniprot_entry
Q3UEX0_MOUSE
resolver
uniprot_sec
Q548Z4
resolver
amino_acid_sequence
MAQRLTGEQTLDHYEDSTHASIFTYTNSNSTKGPFEGPNYHIAPRWVYHLTSTWMILVVVASVFTNGLVLAATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCVIEGYIVSLCGITGLWSLAIISWERWLVVCKPFGNVRFDAKLATVGIVFSWVWAAIWTAPPIFGWSRYWPYGLKTSCGPDVFSGTSYPGVQSYMMVLMVTCCIFPLSIIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMVFAYCLCWGPYTFFACFATAHPGYAFHPLVASLPSYFAKSATIYNPIIYVFMNRQFRNCILHLFGKKVDDSSELSSTSKTEVSSVSSVSPA
uniprot
proteins
function
FUNCTION: G protein-coupled photoreceptor that selectively activates transducin G alpha protein (G(t)) in response to medium-wavelength (green) light, thereby stimulating the G(t)/transducin protein pathway (By similarity). This activation leads to increased cGMP phosphodiesterase activity, resulting in decreased intracellular cGMP and subsequent closure of cGMP-gated ion channels. The process is initiated when the opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers the G protein-mediated phototransduction cascade (By similarity). Mediates visual perception of green light in cone photoreceptor cells (PubMed:11055434). {ECO:0000250|UniProtKB:P04000, ECO:0000250|UniProtKB:P04001, ECO:0000269|PubMed:11055434}.
uniprot
proteins
mass_dalton
40218
uniprot
proteins
post_translational_modification
PTM: N-glycosylated (PubMed:30948514). O-glycosylated (PubMed:30948514). {ECO:0000269|PubMed:30948514}.; PTM: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region. {ECO:0000250|UniProtKB:P04001}.; PTM: Contains one retinal chromophore covalently bound to a lysine residue via a Schiff base. Upon light absorption, the bound 11-cis-retinal isomerizes to all-trans-retinal. Following activation, the covalently bound all-trans-retinal is released through hydrolysis of the Schiff base, and OPN1 is regenerated by binding a new 11-cis-retinal molecule. {ECO:0000250|UniProtKB:P04001}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Opsin subfamily
uniprot
proteins
pubmed
11055434
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23001562
uniprot
proteins
pubmed
30948514
uniprot
proteins
pubmed
9238068
uniprot
proteins
sequence_length
359
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P04001}; Multi-pass membrane protein {ECO:0000255}. Photoreceptor outer segment membrane {ECO:0000269|PubMed:11055434}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 48..72; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 85..110; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 125..144; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 164..187; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 214..241; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 264..287; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 296..320; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins