NOS2
entrez
4843
canonical
uniprot
P35228
canonical
ensembl
ENSG00000007171
resolver
ensp
ENSP00000327251
resolver
genesymbol
NOS2
resolver
genesymbol_syn
NOS2A
resolver
hgnc
HGNC:7873
resolver
uniprot
A1L3U5
resolver
uniprot
B7ZLY2
resolver
uniprot
O60757
resolver
uniprot
O94994
resolver
uniprot
Q16263
resolver
uniprot
Q16692
resolver
uniprot
Q4TTS5
resolver
uniprot
Q9UD42
resolver
uniprot_entry
NOS2_HUMAN
resolver
uniprot_sec
A1L3U5
resolver
uniprot_sec
B7ZLY2
resolver
uniprot_sec
O60757
resolver
uniprot_sec
O94994
resolver
uniprot_sec
Q16263
resolver
uniprot_sec
Q16692
resolver
uniprot_sec
Q4TTS5
resolver
uniprot_sec
Q9UD42
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by calcium/calmodulin. Aspirin inhibits expression and function of this enzyme and effects may be exerted at the level of translational/post-translational modification and directly on the catalytic activity (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MACPWKFLFKTKFHQYAMNGEKDINNNVEKAPCATSSPVTQDDLQYHNLSKQQNESPQPLVETGKKSPESLVKLDATPLSSPRHVRIKNWGSGMTFQDTLHHKAKGILTCRSKSCLGSIMTPKSLTRGPRDKPTPPDELLPQAIEFVNQYYGSFKEAKIEEHLARVEAVTKEIETTGTYQLTGDELIFATKQAWRNAPRCIGRIQWSNLQVFDARSCSTAREMFEHICRHVRYSTNNGNIRSAITVFPQRSDGKHDFRVWNAQLIRYAGYQMPDGSIRGDPANVEFTQLCIDLGWKPKYGRFDVVPLVLQANGRDPELFEIPPDLVLEVAMEHPKYEWFRELELKWYALPAVANMLLEVGGLEFPGCPFNGWYMGTEIGVRDFCDVQRYNILEEVGRRMGLETHKLASLWKDQAVVEINIAVLHSFQKQNVTIMDHHSAAESFMKYMQNEYRSRGGCPADWIWLVPPMSGSITPVFHQEMLNYVLSPFYYYQVEAWKTHVWQDEKRRPKRREIPLKVLVKAVLFACMLMRKTMASRVRVTILFATETGKSEALAWDLGALFSCAFNPKVVCMDKYRLSCLEEERLLLVVTSTFGNGDCPGNGEKLKKSLFMLKELNNKFRYAVFGLGSSMYPRFCAFAHDIDQKLSHLGASQLTPMGEGDELSGQEDAFRSWAVQTFKAACETFDVRGKQHIQIPKLYTSNVTWDPHHYRLVQDSQPLDLSKALSSMHAKNVFTMRLKSRQNLQSPTSSRATILVELSCEDGQGLNYLPGEHLGVCPGNQPALVQGILERVVDGPTPHQTVRLEALDESGSYWVSDKRLPPCSLSQALTYFLDITTPPTQLLLQKLAQVATEEPERQRLEALCQPSEYSKWKFTNSPTFLEVLEEFPSLRVSAGFLLSQLPILKPRFYSISSSRDHTPTEIHLTVAVVTYHTRDGQGPLHHGVCSTWLNSLKPQDPVPCFVRNASGFHLPEDPSHPCILIGPGTGIAPFRSFWQQRLHDSQHKGVRGGRMTLVFGCRRPDEDHIYQEEMLEMAQKGVLHAVHTAYSRLPGKPKVYVQDILRQQLASEVLRVLHKEPGHLYVCGDVRMARDVAHTLKQLVAAKLKLNEEQVEDYFFQLKSQKRYHEDIFGAVFPYEAKKDRVAVQPSSLEMSAL
uniprot
proteins
ec_number
1.14.13.39
uniprot
proteins
function
FUNCTION: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body (PubMed:7504305, PubMed:7531687, PubMed:7544004, PubMed:7682706). In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2 (By similarity). As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH on 'Cys-247' implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM (PubMed:25417112). Involved in inflammation, enhances the synthesis of pro-inflammatory mediators such as IL6 and IL8 (PubMed:19688109). {ECO:0000250|UniProtKB:P29477, ECO:0000269|PubMed:19688109, ECO:0000269|PubMed:25417112, ECO:0000269|PubMed:7504305, ECO:0000269|PubMed:7531687, ECO:0000269|PubMed:7544004, ECO:0000269|PubMed:7682706}.
uniprot
proteins
mass_dalton
131117
uniprot
proteins
mutagenesis
MUTAGEN 27; /note="N->A: Loss of interaction with SPSB1 and SPSB4."; /evidence="ECO:0000269|PubMed:21199876
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated; mediated by SPSB1, SPSB2 and SPSB4, leading to proteasomal degradation. {ECO:0000269|PubMed:21199876}.
uniprot
proteins
protein_family
NOS family
uniprot
proteins
pubmed
10074942
uniprot
proteins
pubmed
10409685
uniprot
proteins
pubmed
12080081
uniprot
proteins
pubmed
12433515
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
19688109
uniprot
proteins
pubmed
19737939
uniprot
proteins
pubmed
21199876
uniprot
proteins
pubmed
24430113
uniprot
proteins
pubmed
25180171
uniprot
proteins
pubmed
25417112
uniprot
proteins
pubmed
35772285
uniprot
proteins
pubmed
7504305
uniprot
proteins
pubmed
7522054
uniprot
proteins
pubmed
7528017
uniprot
proteins
pubmed
7528267
uniprot
proteins
pubmed
7531687
uniprot
proteins
pubmed
7532248
uniprot
proteins
pubmed
7544004
uniprot
proteins
pubmed
7558036
uniprot
proteins
pubmed
7682706
uniprot
proteins
pubmed
7692964
uniprot
proteins
pubmed
9160867
uniprot
proteins
pubmed
9721329
uniprot
proteins
sequence_length
1153
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:21199876}. Note=Localizes as discrete foci scattered throughout the cytosol and in the presence of SPSB1 and SPSB4, exhibits a more diffuse cytosolic localization. {ECO:0000269|PubMed:21199876}.
uniprot
proteins