Pkdcc
entrez
106522
canonical
uniprot
Q5RJI4
canonical
ensembl
ENSMUSG00000024247
resolver
ensp
ENSMUSP00000129238
resolver
ensp
ENSMUSP00000187635
resolver
genesymbol
Pkdcc
resolver
genesymbol_syn
Sgk493
resolver
genesymbol_syn
Vlk
resolver
uniprot
B6F136
resolver
uniprot
Q3UZD3
resolver
uniprot
Q8VBZ6
resolver
uniprot_entry
PKDCC_MOUSE
resolver
uniprot_sec
B6F136
resolver
uniprot_sec
Q3UZD3
resolver
uniprot_sec
Q8VBZ6
resolver
amino_acid_sequence
MRRRRAAVAAGFCASFLLGSVLNVLFAPGSEPPRPGQSPGSSAAPGPGRRGGRGELARQIRERYEEVQRYSRGGPGPGAGRPERRRLMDLAPGGPGLQRPRPPRVRSPPDGAPGWPPAPGPGSPGPGPRLGCAALRNVSGAQYVGSGYTKAVYRVRLPGGAAVALKAVDFSGHDLGSCVREFGARRGCYRLAAHKLLKEMVLLERLRHPNVLQLYGYCYQDSEGIPDTLTTITELGAPVEMIQLLQTSWEDRFRICLSLGRLLHHLAHSPLGSVTLLDFRPRQFVLVNGELKVTDLDDARVEETPCTSSADCTLEFPARNFSLPCSAQGWCEGMNEKRNLYNAYRFFFTYLLPHSAPPSLRPLLDSIVNATGELAWGVDETLAQLETALHLFRSGQYLQNSTSSRAEYQRIPDSAITQEDYRCWPSYHHGGCLLSVFNLAEAIDVCESHAQCRAFVVTNQTTWTGRKLVFFKTGWNQVVPDAGKTTYVKAPG
uniprot
proteins
ec_number
2.7.10.2
uniprot
proteins
function
FUNCTION: Secreted tyrosine-protein kinase that mediates phosphorylation of extracellular proteins and endogenous proteins in the secretory pathway, which is essential for patterning at organogenesis stages. Mediates phosphorylation of MMP1, MMP13, MMP14, MMP19 and ERP29 (PubMed:25171405). May also have serine/threonine protein kinase activity (PubMed:25171405). Required for longitudinal bone growth through regulation of chondrocyte differentiation (PubMed:19097194, PubMed:23792766). May be indirectly involved in protein transport from the Golgi apparatus to the plasma membrane (PubMed:19465597). Probably plays a role in platelets: rapidly and quantitatively secreted from platelets in response to stimulation of platelet degranulation (PubMed:25171405). {ECO:0000269|PubMed:19097194, ECO:0000269|PubMed:19465597, ECO:0000269|PubMed:23792766, ECO:0000269|PubMed:25171405}.
uniprot
proteins
mass_dalton
53841
uniprot
proteins
mutagenesis
MUTAGEN 148; /note="Y->F: Does not affect kinase activity nor secretion to the extracellular medium."; /evidence="ECO:0000269|PubMed:25171405"; MUTAGEN 166; /note="K->M: Complete loss of kinase activity. Phosphorylation is restored by co-transfection with wild-type protein."; /evidence="ECO:0000269|PubMed:19465597, ECO:0000269|PubMed:25171405"; MUTAGEN 199; /note="E->A: Complete loss of kinase activity."; /evidence="ECO:0000269|PubMed:25171405"; MUTAGEN 295; /note="D->A: Complete loss of kinase activity."; /evidence="ECO:0000269|PubMed:25171405
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosines; probably via autophosphorylation. {ECO:0000269|PubMed:25171405}.; PTM: N-glycosylated. {ECO:0000269|PubMed:25171405}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19097194
uniprot
proteins
pubmed
19465597
uniprot
proteins
pubmed
23792766
uniprot
proteins
pubmed
25171405
uniprot
proteins
sequence_length
492
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25171405}. Golgi apparatus {ECO:0000269|PubMed:19465597}. Note=Both secreted and present in the Golgi apparatus. {ECO:0000269|PubMed:19465597, ECO:0000269|PubMed:25171405}.
uniprot
proteins