Prkd3
entrez
75292
canonical
uniprot
Q8K1Y2
canonical
ensembl
ENSMUSG00000024070
resolver
ensp
ENSMUSP00000003191
resolver
ensp
ENSMUSP00000113232
resolver
ensp
ENSMUSP00000113395
resolver
ensp
ENSMUSP00000132004
resolver
enst
ENSMUST00000003191
resolver
enst
ENSMUST00000118768
resolver
enst
ENSMUST00000119284
resolver
enst
ENSMUST00000168887
resolver
genesymbol
Prkd3
resolver
genesymbol_syn
Prkcn
resolver
uniprot
D3Z6I0
resolver
uniprot
F7CBP8
resolver
uniprot
Q5FWX6
resolver
uniprot_entry
D3Z6I0_MOUSE
resolver
uniprot_entry
F7CBP8_MOUSE
resolver
uniprot_entry
KPCD3_MOUSE
resolver
uniprot_entry
Q5FWX6_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Activated by DAG and phorbol esters. Phorbol-ester/DAG-type domains 1 and 2 bind both DAG and phorbol ester with high affinity and mediate translocation to the cell membrane. Autophosphorylation of Ser-734 and phosphorylation of Ser-730 by PKC relieves auto-inhibition by the PH domain.
uniprot
proteins
amino_acid_sequence
MSANNSPPSAQKSVFPATVSAVLPAPSPCSSPKTGLSARLSNGSFSAPSLTNSRGSVHTVSFLLQIGLTRESVTIEAQELSLSAVKDLVCSIVYQKFPECGFFGMYDKILLFRHDMNSENILQLITSADEIHEGDLVEVVLSALATVEDFQIRPHALYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQPECVPLLSEESHTHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYGRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEVTFNGEPCSVGTDADMPMDIDSSDVNSDGSRGLDDSEEPSPPEDKMFFLDPTDLDVERDEETVKTISPSTSNNIPLMRVVQSIKHTKRRSSTVVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRVSSPQDFTSISQGSNPHCFEIITDTVVYFVGENNGSSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDHNLATSISVSNCQVQENVDISSVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIVYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISSEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLREFETRIGERYITHESDDARWEIHAYTHNLEYPKHFIMAPNPDDMEEDP
uniprot
proteins
ec_number
2.7.11.13
uniprot
proteins
function
FUNCTION: Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
100078
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
PKD subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
889
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Note=Translocation to the cell membrane is required for kinase activation. {ECO:0000250}.
uniprot
proteins