IFIT mRNA restriction evasion by virus
uniprot_keyword
KW-1196
canonical
name
IFIT mRNA restriction evasion by virus
uniprot
definition
Viral protein allowing host innate defense evasion by methylating the first and second ribonucleotide of viral mRNAs (cap1 and cap2). These methylations allow viral RNA to escape cellular antiviral process mediated by host IFIT proteins which degrade non cap1-methylated mRNAs. Also prevents IFIH1/MDA5 sensor activation by cap0 mRNAs, which would trigger interferon beta synthesis.
uniprot
keywords
is_obsolete
false
uniprot
keywords
ontology_id
uniprot_keywords
uniprot
keywords