Aplp1
entrez
11803
canonical
uniprot
Q03157
canonical
ensembl
ENSMUSG00000006651
resolver
ensp
ENSMUSP00000006828
resolver
enst
ENSMUST00000006828
resolver
genesymbol
Aplp1
resolver
uniprot
A0A0R4IZZ1
resolver
uniprot
Q3TUB1
resolver
uniprot
Q3U311
resolver
uniprot
Q8VC38
resolver
uniprot_entry
APLP1_MOUSE
resolver
uniprot_entry
Q3TUB1_MOUSE
resolver
uniprot_sec
A0A0R4IZZ1
resolver
uniprot_sec
Q3U311
resolver
uniprot_sec
Q8VC38
resolver
amino_acid_sequence
MGPTSPAARGQGRRWRPPPLPLLLPLSLLLLRAQLAVGNLAVGSPSAAEAPGSAQVAGLCGRLTLHRDLRTGRWEPDPQRSRRCLLDPQRVLEYCRQMYPELHIARVEQAAQAIPMERWCGGTRSGRCAHPHHEVVPFHCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQGLILHGSGMLLPCGSDRFRGVEYVCCPPPATPNPSGMAAGDPSTRSWPLGGRAEGGEDEEEVESFPQPVDDYFVEPPQAEEEEEEEEERAPPPSSHTPVMVSRVTPTPRPTDGVDVYFGMPGEIGEHEGFLRAKMDLEERRMRQINEVMREWAMADSQSKNLPKADRQALNEHFQSILQTLEEQVSGERQRLVETHATRVIALINDQRRAALEGFLAALQGDPPQAERVLMALRRYLRAEQKEQRHTLRHYQHVAAVDPEKAQQMRFQVQTHLQVIEERMNQSLGLLDQNPHLAQELRPQIQELLLAEHLGPSELDASVPGSSSEDKGSLQPPESKDDPPVTLPKGSTDQESSSSGREKLTPLEQYEQKVNASAPRGFPFHSSDIQRDELAPSGTGVSREALSGLLIMGAGGGSLIVLSLLLLRKKKPYGTISHGVVEVDPMLTLEEQQLRELQRHGYENPTYRFLEERP
uniprot
proteins
function
FUNCTION: May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding. Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I.; FUNCTION: The gamma-CTF peptide, C30, is a potent enhancer of neuronal apoptosis. {ECO:0000250}.
uniprot
proteins
mass_dalton
72848
uniprot
proteins
mutagenesis
MUTAGEN 642; /note="Y->G: Reduced binding of APBB1."; /evidence="ECO:0000269|PubMed:12228233
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved by caspases during neuronal apoptosis. Cleaved, in vitro, at Asp-624 by caspase-3 (By similarity). {ECO:0000250}.; PTM: N- and O-glycosylated.
uniprot
proteins
protein_family
APP family
uniprot
proteins
pubmed
10460257
uniprot
proteins
pubmed
11247302
uniprot
proteins
pubmed
11517249
uniprot
proteins
pubmed
12228233
uniprot
proteins
pubmed
1279693
uniprot
proteins
pubmed
12826668
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16314516
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8576160
uniprot
proteins
sequence_length
654
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [C30]: Cytoplasm. Note=C-terminally processed in the Golgi complex.
uniprot
proteins
transmembrane_region
TRANSMEM 585..607; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins