Actr2
entrez
66713
canonical
uniprot
P61161
canonical
ensembl
ENSMUSG00000020152
resolver
ensp
ENSMUSP00000000137
resolver
ensp
ENSMUSP00000319413
resolver
enst
ENSMUST00000000137
resolver
genesymbol
Actr2
resolver
genesymbol_syn
Arp2
resolver
uniprot
O15142
resolver
uniprot
Q5SW83
resolver
uniprot
Q6PI31
resolver
uniprot_entry
ARP2_MOUSE
resolver
uniprot_entry
Q5SW83_MOUSE
resolver
uniprot_sec
O15142
resolver
uniprot_sec
Q6PI31
resolver
amino_acid_sequence
MDSQGRKVVVCDNGTGFVKCGYAGSNFPEHIFPALVGRPIIRSTTKVGNIEIKDLMVGDEASELRSMLEVNYPMENGIVRNWDDMKHLWDYTFGPEKLNIDTRNCKILLTEPPMNPTKNREKIVEVMFETYQFSGVYVAIQAVLTLYAQGLLTGVVVDSGDGVTHICPVYEGFSLPHLTRRLDIAGRDITRYLIKLLLLRGYAFNHSADFETVRMIKEKLCYVGYNIEQEQKLALETTVLVESYTLPDGRIIKVGGERFEAPEALFQPHLINVEGVGVAELLFNTIQAADIDTRSEFYKHIVLSGGSTMYPGLPSRLERELKQLYLERVLKGDVEKLSKFKIRIEDPPRRKHMVFLGGAVLADIMKDKDNFWMTRQEYQEKGVRVLEKLGVTVR
uniprot
proteins
function
FUNCTION: ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). {ECO:0000250|UniProtKB:P61160}.
uniprot
proteins
mass_dalton
44761
uniprot
proteins
protein_family
ARP2 subfamily
uniprot
proteins
protein_family
Actin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20693329
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
394
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P61160}. Cell projection {ECO:0000250|UniProtKB:P61160}. Nucleus {ECO:0000250|UniProtKB:P61160}.
uniprot
proteins