BRD3
entrez
8019
canonical
uniprot
Q15059
canonical
ensembl
ENSG00000169925
resolver
ensp
ENSP00000305918
resolver
ensp
ENSP00000554056
resolver
ensp
ENSP00000554057
resolver
ensp
ENSP00000554059
resolver
ensp
ENSP00000603253
resolver
genesymbol
BRD3
resolver
genesymbol_syn
KIAA0043
resolver
genesymbol_syn
RING3L
resolver
hgnc
HGNC:1104
resolver
uniprot
B1APD9
resolver
uniprot
Q4G5Y3
resolver
uniprot
Q5T1R7
resolver
uniprot
Q8N5M3
resolver
uniprot
Q92645
resolver
uniprot_entry
BRD3_HUMAN
resolver
uniprot_sec
B1APD9
resolver
uniprot_sec
Q4G5Y3
resolver
uniprot_sec
Q5T1R7
resolver
uniprot_sec
Q8N5M3
resolver
uniprot_sec
Q92645
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by JQ1, a thieno-triazolo-1,4-diazepine derivative, which specifically inhibits members of the BET family (BRD2, BRD3 and BRD4) (PubMed:20871596). The first bromo domain is inhibited by GSK778 (iBET-BD1), which specifically inhibits the first bromo domain of members of the BET family (BRD2, BRD3 and BRD4) (PubMed:32193360). The second bromo domain is inhibited by ABBV-744, which specifically inhibits the second bromo domain of members of the BET family (BRD2, BRD3 and BRD4) (PubMed:31969702). The second bromo domain is inhibited by GSK046 (iBET-BD2), which specifically inhibits the second bromo domain of members of the BET family (BRD2, BRD3 and BRD4) (PubMed:32193360). {ECO:0000269|PubMed:20871596, ECO:0000269|PubMed:31969702, ECO:0000269|PubMed:32193360}.
uniprot
proteins
amino_acid_sequence
MSTATTVAPAGIPATPGPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQSAGTQQVAAVSSVSPATPFQSVPPTVSQTPVIAATPVPTITANVTSVPVPPAAAPPPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLSDPKQAKVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLRYCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDGREYPDAQGFAADVRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPVEAPALPAPAAPMVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKKKKEKKEKEKKKKDKEKEKEKHKVKAEEEKKAKVAPPAKQAQQKKAPAKKANSTTTAGRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPFSASGKKQAAKSKEELAQEKKKELEKRLQDVSGQLSSSKKPARKEKPGSAPSGGPSRLSSSSSSESGSSSSSGSSSDSSDSE
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUTM1 which produces a BRD3-NUTM1 fusion protein. {ECO:0000269|PubMed:17934517}.
uniprot
proteins
function
FUNCTION: Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures (PubMed:18406326, PubMed:22464331, PubMed:27105114, PubMed:32895492). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (PubMed:29567837, PubMed:32895492). In vitro, binds acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (PubMed:18406326). Involved in endoderm differentiation via its association with long non-coding RNA (lncRNA) DIGIT: BRD3 undergoes liquid-liquid phase separation upon binding to lncRNA DIGIT, promoting binding to histone H3 acetylated at 'Lys-18' (H3K18ac) to induce endoderm gene expression (PubMed:32895492). Also binds non-histones acetylated proteins, such as GATA1 and GATA2: regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). {ECO:0000250|UniProtKB:Q8K2F0, ECO:0000269|PubMed:18406326, ECO:0000269|PubMed:22464331, ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:29567837, ECO:0000269|PubMed:32895492}.
uniprot
proteins
mass_dalton
79542
uniprot
proteins
protein_family
BET family
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16008511
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17934517
uniprot
proteins
pubmed
18406326
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20871596
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22464331
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25593309
uniprot
proteins
pubmed
27105114
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
29567837
uniprot
proteins
pubmed
31969702
uniprot
proteins
pubmed
32193360
uniprot
proteins
pubmed
32895492
uniprot
proteins
pubmed
33592170
uniprot
proteins
pubmed
7584044
uniprot
proteins
pubmed
9373153
uniprot
proteins
sequence_length
726
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25593309}. Chromosome {ECO:0000269|PubMed:18406326}. Note=Detected on chromatin. {ECO:0000269|PubMed:18406326}.
uniprot
proteins