Spata18
entrez
73472
canonical
uniprot
Q0P557
canonical
ensembl
ENSMUSG00000029155
resolver
ensp
ENSMUSP00000064308
resolver
ensp
ENSMUSP00000300467
resolver
genesymbol
Spata18
resolver
genesymbol_syn
Mieap
resolver
uniprot
B7ZMP4
resolver
uniprot_entry
MIEAP_MOUSE
resolver
uniprot_sec
B7ZMP4
resolver
amino_acid_sequence
MAESLKKLAKSESLQALQDKVTYWVNDYNSNSCDQNLNYCIELIEQVAKVQAQLFGILTVTAQEGGNNEGVETIKCRLLPLLQTSFSSVNMGKTAESEMCATQDFQLRSKNRDNSPDQDQHQSDNESFSETQPTQVQDDLAESGKSLEGAKNGSTISLLAAEEEINQLKKQLKSLQAQEDARHKTSENRRSEALKSDHRSTKRTQDQRPQDVVSNYEKHLQNLKEEIAVLSAEKSGLQGRSARSPSPSTGTRSHRRGRSRSHSRSRSHSRSNSPCTTVAKIRSPSPNRAKMSSVARKAALLSRFSDAYSQARLDAQCLLRRCIDRAETVQRIIYIATVEAFHVAKMAFRHFKIRVRKMLTPSNVGSNTDFETAVSEYIVCHLDLYDSQSSVNDVIRAMNVNPKISFPPEVDFCLLTDFIQEICCIAFAMQSLEPPLDIAFGADGEIFNDCKYRRSYDSDFTAPLVFYHVWPALMENDCVIMKGEAVTKRGAFWSSVRPVMRCRSRSLSPICPRNHFGISTVSRSRSPSPIRCTFARY
uniprot
proteins
function
FUNCTION: Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. Binds cardiolipin. May form molecular condensates (non-membrane-bounded organelles) within mitochondria that compartmentalize and promote cardiolipin metabolism. {ECO:0000250|UniProtKB:Q8TC71}.
uniprot
proteins
mass_dalton
60398
uniprot
proteins
protein_family
MIEAP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21300779
uniprot
proteins
sequence_length
537
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8TC71}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8TC71}. Mitochondrion matrix {ECO:0000250|UniProtKB:Q8TC71}. Note=Localizes to the cytosol under normal conditions. Relocalizes to mitochondrion outer membrane following cellular stress. May form molecular condensates in the mitochondrial matrix. Colocalizes with BNIP3 and BNIP3L at the mitochondrion outer membrane. {ECO:0000250|UniProtKB:Q8TC71}.
uniprot
proteins