Inpp5e
entrez
64436
canonical
uniprot
Q9JII1
canonical
ensembl
ENSMUSG00000026925
resolver
ensp
ENSMUSP00000109724
resolver
ensp
ENSMUSP00000119485
resolver
enst
ENSMUST00000114090
resolver
enst
ENSMUST00000145701
resolver
genesymbol
Inpp5e
resolver
uniprot
A2AIX0
resolver
uniprot
Q3TCC9
resolver
uniprot_entry
A2AIX0_MOUSE
resolver
uniprot_entry
INP5E_MOUSE
resolver
uniprot_sec
Q3TCC9
resolver
amino_acid_sequence
MPSKSACLRHTEAPGQLEGRMLQGQPPNTEKKLIPTPGFLPASDSQGSETNPMPPFSIPAKTSNQNPQTKANLITPQPPIRPKLERTLSLDDKGWRRRRFRGSQEDLTVQNGASPCRGSLQDSVAQSPAYSRPLPCLSTSLQEIPKSRRATGSEGGSPSLWSDCLSGMISTSLDLLHRDAASGGPPSRLASLHASHTPPAMDLSIASSSLRTANKVDPEHTDYKLRMQTRLVRAHSNLGPSRPRSPLAGDDHSIHSARSFSLLAPIRTKDIRSRSYLEGSLLASGALLGAEELARYFPDRNMALFVATWNMQGQKELPASLDEFLLPTEADYTQDLYVIGIQEGCSDRREWETRLQETLGPQYVLLSSAAHGVLYMSLFIRRDLIWFCSEVEYSTVTTRIVSQIKTKGALGVSFTFFGTSFLFITSHFTSGDGKVAERLLDYSRTIQALALPRNVPDTNPYRSSAGDVTTRFDEVFWFGDFNFRLSGGRVAVEAFLKQKPEVDVLALLQHDQLTREMKKGSIFRGFEEAEIHFLPSYKFDIGKDTYDSTSKQRTPSYTDRVLYKSRHKGDICPMKYSSCPGIKTSDHRPVYGLFQVKVRPGRDNIPLAAGKFDRELYLIGIKRRISKEIQRQEALKSQSSSAVCTVS
uniprot
proteins
ec_number
3.1.3.36
uniprot
proteins
ec_number
3.1.3.86
uniprot
proteins
function
FUNCTION: Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Specific for lipid substrates, inactive towards water soluble inositol phosphates. Specific for lipid substrates, inactive towards water soluble inositol phosphates (By similarity) (PubMed:10806194). Can also remove the 5-phosphate from 1D-myo-inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) (By similarity). Plays an essential role in the primary cilium by controlling ciliary growth and phosphoinositide 3-kinase (PI3K) signaling and stability (PubMed:19668215). {ECO:0000250|UniProtKB:Q9NRR6, ECO:0000269|PubMed:10806194, ECO:0000269|PubMed:19668215}.
uniprot
proteins
mass_dalton
71915
uniprot
proteins
protein_family
Inositol polyphosphate 5-phosphatase family
uniprot
proteins
pubmed
10806194
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19668215
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26051944
uniprot
proteins
sequence_length
647
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:19668215}. Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:10806194}; Peripheral membrane protein {ECO:0000269|PubMed:10806194}; Cytoplasmic side {ECO:0000269|PubMed:10806194}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q9WVR1}. Cell membrane {ECO:0000250|UniProtKB:Q9WVR1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9WVR1}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9WVR1}. Cytoplasm {ECO:0000250|UniProtKB:Q9WVR1}. Nucleus {ECO:0000269|PubMed:26051944}. Note=Peripheral membrane protein associated with Golgi stacks. {ECO:0000269|PubMed:10806194}.
uniprot
proteins