Ifitm2
entrez
80876
canonical
uniprot
Q99J93
canonical
ensembl
ENSMUSG00000060591
resolver
ensp
ENSMUSP00000071470
resolver
enst
ENSMUST00000081649
resolver
genesymbol
Ifitm2
resolver
uniprot
Q3TIG4
resolver
uniprot_entry
IFM2_MOUSE
resolver
uniprot_sec
Q3TIG4
resolver
amino_acid_sequence
MSHNSQAFLSTNAGLPPSYETIKEEYGVTELGEPSNSAVVRTTVINMPREVSVPDHVVWSLFNTLFFNACCLGFVAYAYSVKSRDRKMVGDVVGAQAYASTAKCLNISSLIFSILMVIICIIIFSTTSVVVFQSFAQRTPHSGF
uniprot
proteins
function
FUNCTION: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV) and West Nile virus (WNV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. {ECO:0000269|PubMed:21253575}.
uniprot
proteins
mass_dalton
15743
uniprot
proteins
post_translational_modification
PTM: Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity. {ECO:0000250|UniProtKB:Q01629}.; PTM: Phosphorylation at Tyr-19 is required for endosomal and lysosomal location. {ECO:0000250|UniProtKB:Q01629}.
uniprot
proteins
protein_family
CD225/Dispanin family
uniprot
proteins
pubmed
12659663
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16395393
uniprot
proteins
pubmed
21166591
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21253575
uniprot
proteins
pubmed
22363774
uniprot
proteins
sequence_length
144
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q01629}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q01629}. Lysosome membrane {ECO:0000250|UniProtKB:Q01629}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q01629}. Late endosome membrane {ECO:0000250|UniProtKB:Q01629}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q01629}.
uniprot
proteins
transmembrane_region
TRANSMEM 111..131; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins