Sem1
entrez
20422
canonical
uniprot
P60897
canonical
ensembl
ENSMUSG00000042541
resolver
ensp
ENSMUSP00000040741
resolver
enst
ENSMUST00000041111
resolver
genesymbol
Sem1
resolver
genesymbol_syn
Dss1
resolver
genesymbol_syn
Shfdg1
resolver
genesymbol_syn
Shfm1
resolver
uniprot
Q13437
resolver
uniprot
Q3TV35
resolver
uniprot
Q61067
resolver
uniprot_entry
Q3TV35_MOUSE
resolver
uniprot_entry
SEM1_MOUSE
resolver
uniprot_sec
Q13437
resolver
uniprot_sec
Q61067
resolver
amino_acid_sequence
MSEKKQPVDLGLLEEDDEFEEFPAEDWAGLDEDEDAHVWEDNWDDDNVEDDFSNQLRAELEKHGYKMETS
uniprot
proteins
function
FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, SEM1, and either centrin CETN2 or CETN3. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and thus transcription-associated genomic instability. R-loop accumulation increases in SEM1-depleted cells. {ECO:0000250|UniProtKB:P60896}.
uniprot
proteins
mass_dalton
8278
uniprot
proteins
protein_family
DSS1/SEM1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8733122
uniprot
proteins
sequence_length
70
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P60896}.
uniprot
proteins