Il10
entrez
25325
canonical
uniprot
P29456
canonical
ensembl
ENSRNOG00000004647
resolver
ensembl
ENSRNOG00055021506
resolver
ensembl
ENSRNOG00060014812
resolver
ensembl
ENSRNOG00065020717
resolver
ensp
ENSRNOP00000006246
resolver
ensp
ENSRNOP00055029831
resolver
ensp
ENSRNOP00060020176
resolver
ensp
ENSRNOP00065028233
resolver
enst
ENSRNOT00000006246
resolver
enst
ENSRNOT00055036739
resolver
enst
ENSRNOT00060025317
resolver
enst
ENSRNOT00065035115
resolver
genesymbol
Il10
resolver
genesymbol_syn
Il-10
resolver
uniprot
Q63263
resolver
uniprot_entry
IL10_RAT
resolver
uniprot_sec
Q63263
resolver
amino_acid_sequence
MPGSALLCCLLLLAGVKTSKGHSIRGDNNCTHFPVSQTHMLRELRAAFSQVKTFFQKKDQLDNILLTDSLLQDFKGYLGCQALSEMIKFYLVEVMPQAENHGPEIKEHLNSLGEKLKTLWIQLRRCHRFLPCENKSKAVEQVKNDFNKLQDKGVYKAMNEFDIFINCIEAYVTLKMKN
uniprot
proteins
function
FUNCTION: Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines including granulocyte-macrophage colony-stimulating factor /GM-CSF, granulocyte colony-stimulating factor/G-CSF, IL-1 alpha, IL-1 beta, IL-6, IL-8 and TNF. Also interferes with antigen presentation by reducing the expression of MHC-class II and co-stimulatory molecules, thereby inhibiting their ability to induce T cell activation (By similarity). In addition, controls the inflammatory response of macrophages by reprogramming essential metabolic pathways including mTOR signaling (By similarity). {ECO:0000250|UniProtKB:P18893, ECO:0000250|UniProtKB:P22301}.
uniprot
proteins
mass_dalton
20426
uniprot
proteins
protein_family
IL-10 family
uniprot
proteins
pubmed
1280414
uniprot
proteins
pubmed
8484757
uniprot
proteins
sequence_length
178
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P22301}.
uniprot
proteins