Coa8
entrez
68020
canonical
uniprot
Q9CQW7
canonical
ensembl
ENSMUSG00000037787
resolver
ensp
ENSMUSP00000038865
resolver
ensp
ENSMUSP00000131169
resolver
ensp
ENSMUSP00000257733
resolver
genesymbol
Coa8
resolver
genesymbol_syn
Apop1
resolver
genesymbol_syn
Apopt1
resolver
uniprot_entry
COA8_MOUSE
resolver
amino_acid_sequence
MAALRPGSRALRRLLCRSFSGGGGVRLARERPTDHRDAASSRVSRFCPPRQSCHDWIGPPDKCSNLRPVHFHIPENESPLEQRLRELRQETQEWNQQFWAKQNLSFNKEKEEFIYSRLQAKGAGLRTESGQRATLDAEEMADFYKDFLSKNFQKHMRYNRDWYKRNFAITFFMGKVVLERMWSKLRQKKTSS
uniprot
proteins
function
FUNCTION: Required for cytochrome c complex (COX) IV assembly and function Protects COX assembly from oxidation-induced degradation, COX being the terminal component of the mitochondrial respiratory chain. {ECO:0000269|PubMed:30552096}.
uniprot
proteins
mass_dalton
22715
uniprot
proteins
post_translational_modification
PTM: N-terminal mitochondrial targeting sequence is cleaved from the mature protein once in the mitochondrion. {ECO:0000250|UniProtKB:Q96IL0}.; PTM: In normal conditions, the cytoplasmic precursor protein is rapidly degraded by the ubiquitination-proteasome system (UPS). Oxidative stress induces protein stabilization and import into mitochondria where it protects COX from degradation. {ECO:0000250|UniProtKB:Q96IL0}.
uniprot
proteins
protein_family
COA8 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16782708
uniprot
proteins
pubmed
18977203
uniprot
proteins
pubmed
30552096
uniprot
proteins
sequence_length
192
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:16782708, ECO:0000305|PubMed:18977203}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q96IL0}; Matrix side {ECO:0000250|UniProtKB:Q96IL0}.
uniprot
proteins