ENTPD6
entrez
955
canonical
uniprot
O75354
canonical
ensembl
ENSG00000197586
resolver
ensp
ENSP00000347084
resolver
ensp
ENSP00000353131
resolver
ensp
ENSP00000365840
resolver
ensp
ENSP00000365854
resolver
ensp
ENSP00000401895
resolver
ensp
ENSP00000556680
resolver
ensp
ENSP00000556682
resolver
ensp
ENSP00000556685
resolver
ensp
ENSP00000556691
resolver
ensp
ENSP00000624473
resolver
ensp
ENSP00000660898
resolver
ensp
ENSP00000727417
resolver
ensp
ENSP00000727419
resolver
ensp
ENSP00000727428
resolver
ensp
ENSP00000728110
resolver
ensp
ENSP00000728112
resolver
enst
ENST00000354989
resolver
enst
ENST00000433259
resolver
genesymbol
ENTPD6
resolver
genesymbol_syn
CD39L2
resolver
genesymbol_syn
IL6ST2
resolver
hgnc
HGNC:3368
resolver
uniprot
A6NCX6
resolver
uniprot
B4DDM7
resolver
uniprot
B4DHS2
resolver
uniprot
B4DU64
resolver
uniprot
B4E1D1
resolver
uniprot
D3DW49
resolver
uniprot
Q5QPI9
resolver
uniprot
Q5QPJ2
resolver
uniprot
Q5QPJ5
resolver
uniprot
Q7Z5B5
resolver
uniprot
Q8N3H3
resolver
uniprot
Q8TAS7
resolver
uniprot
Q9UJD1
resolver
uniprot_entry
B4DDM7_HUMAN
resolver
uniprot_entry
B4DHS2_HUMAN
resolver
uniprot_entry
B4DU64_HUMAN
resolver
uniprot_entry
B4E1D1_HUMAN
resolver
uniprot_entry
ENTP6_HUMAN
resolver
uniprot_entry
Q5QPI9_HUMAN
resolver
uniprot_sec
A6NCX6
resolver
uniprot_sec
D3DW49
resolver
uniprot_sec
Q5QPJ2
resolver
uniprot_sec
Q5QPJ5
resolver
uniprot_sec
Q7Z5B5
resolver
uniprot_sec
Q8N3H3
resolver
uniprot_sec
Q8TAS7
resolver
uniprot_sec
Q9UJD1
resolver
activity_regulation
ACTIVITY REGULATION: Glycosylation does not appear to be required for enzymatic activity. {ECO:0000269|PubMed:14529283}.
uniprot
proteins
amino_acid_sequence
MKKGIRYETSRKTSYIFQQPQHGPWQTRMRKISNHGSLRVAKVAYPLGLCVGVFIYVAYIKWHRATATQAFFSITRAAPGARWGQQAHSPLGTAADGHEVFYGIMFDAGSTGTRVHVFQFTRPPRETPTLTHETFKALKPGLSAYADDVEKSAQGIRELLDVAKQDIPFDFWKATPLVLKATAGLRLLPGEKAQKLLQKVKKVFKASPFLVGDDCVSIMNGTDEGVSAWITINFLTGSLKTPGGSSVGMLDLGGGSTQIAFLPRVEGTLQASPPGYLTALRMFNRTYKLYSYSYLGLGLMSARLAILGGVEGQPAKDGKELVSPCLSPSFKGEWEHAEVTYRVSGQKAAASLHELCAARVSEVLQNRVHRTEEVKHVDFYAFSYYYDLAAGVGLIDAEKGGSLVVGDFEIAAKYVCRTLETQPQSSPFSCMDLTYVSLLLQEFGFPRSKVLKLTRKIDNVETSWALGAIFHYIDSLNRQKSPAS
uniprot
proteins
ec_number
3.6.1.6
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of nucleoside triphosphates and diphosphates in a calcium- or magnesium-dependent manner. Has a strong preference for nucleoside diphosphates, preferentially hydrolyzes GDP, IDP, and UDP, with slower hydrolysis of CDP, ITP, GTP, CTP, ADP, and UTP and virtually no hydrolysis of ATP (PubMed:10948193, PubMed:11041856, PubMed:14529283). The membrane bound form might support glycosylation reactions in the Golgi apparatus and, when released from cells, might catalyze the hydrolysis of extracellular nucleotides (PubMed:10948193, PubMed:11041856, PubMed:14529283). {ECO:0000269|PubMed:10948193, ECO:0000269|PubMed:11041856, ECO:0000269|PubMed:14529283}.
uniprot
proteins
mass_dalton
53246
uniprot
proteins
mutagenesis
MUTAGEN 215; /note="C->S: Does not affect nucleoside-triphosphatase activity. Does not affeet KM for GDP."; /evidence="ECO:0000269|PubMed:14529283
uniprot
proteins
post_translational_modification
PTM: The secreted form may be produced by intracellular processing. {ECO:0000305|PubMed:11041856}.; PTM: N-glycosylated. {ECO:0000269|PubMed:10948193, ECO:0000269|PubMed:11041856}.
uniprot
proteins
protein_family
GDA1/CD39 NTPase family
uniprot
proteins
pubmed
10948193
uniprot
proteins
pubmed
11041856
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14529283
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
9676430
uniprot
proteins
sequence_length
484
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9ER31}; Single-pass type II membrane protein {ECO:0000255}. Secreted {ECO:0000269|PubMed:10948193, ECO:0000269|PubMed:11041856}. Cell membrane {ECO:0000269|PubMed:10948193, ECO:0000269|PubMed:11041856}; Single-pass type II membrane protein {ECO:0000255}. Note=Exists as a secreted and membrane-bound forms in the medium of transfected cells, the secreted form is predominant. {ECO:0000269|PubMed:10948193, ECO:0000269|PubMed:11041856}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..60; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins