Tgm3
entrez
366189
canonical
uniprot
D4A5U3
canonical
ensembl
ENSRNOG00000006753
resolver
ensembl
ENSRNOG00055006066
resolver
ensembl
ENSRNOG00060015625
resolver
ensembl
ENSRNOG00065014410
resolver
ensp
ENSRNOP00000059160
resolver
ensp
ENSRNOP00055007587
resolver
ensp
ENSRNOP00060021428
resolver
ensp
ENSRNOP00065018522
resolver
enst
ENSRNOT00000063828
resolver
enst
ENSRNOT00055009828
resolver
enst
ENSRNOT00060026753
resolver
enst
ENSRNOT00065023799
resolver
genesymbol
Tgm3
resolver
genesymbol_syn
Tgase3
resolver
uniprot_entry
TGM3_RAT
resolver
amino_acid_sequence
MSALEVQNINWQMPMNRRAHHTDKFSSQDFIVRRGQPWEVILLCNRSLESGDNLNFIVSTGPQPSESARTKAVFSISGRNTSGWSAALKASNGNNLFIAIASPVSAPIGLYTLNVEVSSKGRVSSVKLGTFTVLFNPWQQGDDVFMSNHAERQEYVEEDSGIIYVGSTNRIGMVGWNFGQFEEDILSISLSILDRSLNFRRDPATDVARRNDPKYVCRVLSAMINANDDSGVLSGNWSGNYSGGVDPRTWNGSVEILKNWKKSGFRPVQFGQCWVFAGTLNTVLRCLGVPSRVITNFNSAHDTDRNLSVDVYYDAMGNPLEKGSDSVWNFHVWNEGWFVRTDLGPSYNGWQVLDATPQERSQGVFQCGPASVNAIKDGEVDQNFDMIFIFAEVNADRITWIYNNRDGSQKQNSVDTYSIGKYISTKAVGSNSRMDVTIKYKHPEGSKEERQVQQKAMNKLKPNASFGATSSRGPQGEEKEPSISGKFKVTGVLAVGKEVSLALILKNTTSDRKTVTTNMTAWTIVYNGTLVHEVWKDSATISLDPEEEIQYPVKIAYSQYDRYLKADNMIRITAVCKVPDEAEVVVERDVILDNPTLTLEVLDQAQLRKPVVVQMLFSNPLDEPVKNCVLMVEGSGLLRGSLKIDVPALRPKEKSRVRFEIFPTRIGIKQLLADFSCNKFPAIKAMLVIEVSE
uniprot
proteins
ec_number
2.3.2.13
uniprot
proteins
function
FUNCTION: Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold. In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
77230
uniprot
proteins
post_translational_modification
PTM: Activated by proteolytic processing. In vitro activation is commonly achieved by cleavage with dispase, a neutral bacterial protease. Physiological activation may be catalyzed by CTSL and, to a lesser extent, by CTSS (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Transglutaminase family
uniprot
proteins
protein_family
Transglutaminase superfamily
uniprot
proteins
sequence_length
693
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q08188}.
uniprot
proteins