Glul
entrez
24957
canonical
uniprot
P09606
canonical
ensembl
ENSRNOG00000049560
resolver
ensembl
ENSRNOG00055018616
resolver
ensembl
ENSRNOG00060014474
resolver
ensembl
ENSRNOG00065025118
resolver
ensp
ENSRNOP00000065890
resolver
ensp
ENSRNOP00000078038
resolver
ensp
ENSRNOP00055025642
resolver
ensp
ENSRNOP00060019737
resolver
ensp
ENSRNOP00065035495
resolver
enst
ENSRNOT00000118700
resolver
enst
ENSRNOT00055031714
resolver
enst
ENSRNOT00060024776
resolver
enst
ENSRNOT00065043299
resolver
genesymbol
Glul
resolver
genesymbol_syn
Glns
resolver
uniprot
A0A8I5Y1V3
resolver
uniprot
Q6P7Q9
resolver
uniprot_entry
A0A8I5Y1V3_RAT
resolver
uniprot_entry
GLNA_RAT
resolver
uniprot_sec
Q6P7Q9
resolver
activity_regulation
ACTIVITY REGULATION: Glutamine synthetase activity is inhibited by methionine sulfoximine (MSO). {ECO:0000269|PubMed:4403443}.
uniprot
proteins
amino_acid_sequence
MATSASSHLNKGIKQMYMNLPQGEKIQLMYIWVDGTGEGLRCKTRTLDCDPKCVEELPEWNFDGSSTFQSEGSNSDMYLHPVAMFRDPFRRDPNKLVFCEVFKYNRKPAETNLRHSCKRIMDMVSSQHPWFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADKAYGRDIVEAHYRACLYAGIKITGTNAEVMPAQWEFQIGPCEGIRMGDHLWVARFILHRVCEDFGVIATFDPKPIPGNWNGAGCHTNFSTKAMREENGLRCIEEAIDKLSKRHQYHIRAYDPKGGLDNARRLTGFHETSNINDFSAGVANRSASIRIPRIVGQEKKGYFEDRRPSANCDPYAVTEAIVRTCLLNETGDEPFQYKN
uniprot
proteins
ec_number
2.3.1.225
uniprot
proteins
ec_number
6.3.1.2
uniprot
proteins
function
FUNCTION: Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PubMed:28323). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (By similarity). Plays a key role in ammonium detoxification during erythropoiesis: the glutamine synthetase activity is required to remove ammonium generated by porphobilinogen deaminase (HMBS) during heme biosynthesis to prevent ammonium accumulation and oxidative stress (By similarity). Essential for proliferation of fetal skin fibroblasts (By similarity). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development (By similarity). Involved in angiogenesis by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation. May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ. Plays a role in ribosomal 40S subunit biogenesis. Through the interaction with BEST2, inhibits BEST2 channel activity by affecting the gating at the aperture in the absence of intracellular L-glutamate, but sensitizes BEST2 to intracellular L-glutamate, which promotes the opening of BEST2 and thus relieves its inhibitory effect on BEST2 (By similarity). {ECO:0000250|UniProtKB:P15104, ECO:0000250|UniProtKB:P15105, ECO:0000269|PubMed:28323}.
uniprot
proteins
mass_dalton
42268
uniprot
proteins
post_translational_modification
PTM: Palmitoylated; undergoes autopalmitoylation. {ECO:0000250|UniProtKB:P15104}.; PTM: Acetylated by EP300/p300; acetylation is stimulated by increased glutamine levels and promotes ubiquitin-mediated proteasomal degradation. {ECO:0000250|UniProtKB:P15104}.; PTM: Ubiquitinated by ZNRF1 (By similarity). Ubiquitinated by the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex called CRL4(CRBN), leading to proteasomal degradation (By similarity). {ECO:0000250|UniProtKB:P15104, ECO:0000250|UniProtKB:P15105}.
uniprot
proteins
protein_family
Glutamine synthetase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1674354
uniprot
proteins
pubmed
18555765
uniprot
proteins
pubmed
1970548
uniprot
proteins
pubmed
28323
uniprot
proteins
pubmed
2901064
uniprot
proteins
pubmed
4403443
uniprot
proteins
pubmed
6138251
uniprot
proteins
pubmed
7638749
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305|PubMed:28323}. Microsome {ECO:0000305|PubMed:28323}. Mitochondrion {ECO:0000305|PubMed:28323}. Cell membrane {ECO:0000250|UniProtKB:P15104}; Lipid-anchor {ECO:0000250|UniProtKB:P15104}. Note=Mainly localizes in the cytosol, with a fraction associated with the cell membrane. {ECO:0000250|UniProtKB:P15104}.
uniprot
proteins