Cadm4
entrez
260299
canonical
uniprot
Q8R464
canonical
ensembl
ENSMUSG00000054793
resolver
ensp
ENSMUSP00000066880
resolver
enst
ENSMUST00000068023
resolver
genesymbol
Cadm4
resolver
genesymbol_syn
Igsf4c
resolver
genesymbol_syn
Necl4
resolver
genesymbol_syn
Tsll2
resolver
uniprot_entry
CADM4_MOUSE
resolver
amino_acid_sequence
MGRARRFQWPLLLLWAAAAGPGTGQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQLEEFSPRRVRIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVEVREQAVEGGEVELSCLVPRSRPAAVLRWYRDRKELKGVSSGQENGKVWSVASTVRFRVDRKDDGGIVICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEAANKHGHARALYVLVVYDPGAVVEAQTSVPYAIVGGILALLVFLIICVLVGMVWCSVRQKGSYLTHEASGLDEQGEAREAFLNGGDGHKRKEEFFI
uniprot
proteins
function
FUNCTION: Cell adhesion molecule, exhibiting calcium- and magnesium-independent cell-cell adhesion activity (PubMed:14659875). In its palmitoylated form, is required for proper oligodendrocyte maturation and myelination in CNS via its association with other cell adhesion molecules such as CADM2/3 and MAG (PubMed:39327467). May have tumor-suppressor activity (By similarity). {ECO:0000250|UniProtKB:Q8NFZ8, ECO:0000269|PubMed:14659875, ECO:0000269|PubMed:39327467}.
uniprot
proteins
mass_dalton
42723
uniprot
proteins
mutagenesis
MUTAGEN 347; /note="C->A: Loss of palmitoylation and localization to the cell membrane. Knockin mice exhibit severe myelin abnormalities in the central nervous system (CNS), characterized by loss, demyelination, and hypermyelination."; /evidence="ECO:0000269|PubMed:39327467
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:16261159, ECO:0000269|PubMed:39327467}.; PTM: Palmitoylation, specifically at Cys-347 catalyzed by ZDHHC3, is essential for its localization to the plasma membrane and protein stability. This localization is crucial for its function in CNS myelination, particularly through its associations with other cell adhesion molecules like CADM2/3 and MAG. {ECO:0000269|PubMed:39327467}.
uniprot
proteins
protein_family
Nectin family
uniprot
proteins
pubmed
14659875
uniprot
proteins
pubmed
16261159
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
39327467
uniprot
proteins
sequence_length
388
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:39327467}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:39327467}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 325..345; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins