Tbx6
entrez
21389
canonical
uniprot
P70327
canonical
ensembl
ENSMUSG00000030699
resolver
ensp
ENSMUSP00000091579
resolver
genesymbol
Tbx6
resolver
uniprot
B2RU37
resolver
uniprot
Q5SDA2
resolver
uniprot_entry
TBX6_MOUSE
resolver
uniprot_sec
B2RU37
resolver
uniprot_sec
Q5SDA2
resolver
amino_acid_sequence
MYHPRELYPSLGTGYRLGHPQPGADSTFPPALTEGYRYPDLDTSKLDCFLSGIEAAPHTLAAAAPLPLLPSALGPETAPPPPEALHSLPGVSLSLENQELWKEFSAVGTEMIITKAGRRMFPACRVSVTGLDPEARYLFLLDVVPVDGARYRWQGQHWEPSGKAEPRLPDRVYIHPDSPATGAHWMRQPVSFHRVKLTNSTLDPHGHLILHSMHKYQPRIHLVRATQLCSQHWGGVASFRFPETTFISVTAYQNPRITQLKIAANPFAKGFRENGRNCKRERDARVKRKLRGPEPVATEACGSGDTPGGPCDSTLGGDIRDSDPEQAPTPQEAASASAPPCGGPSAEAYLLHPAAFHGAPSHLPARTPSFAEAPDPGRPAPYSAAFLDLQPGPGGSAYQAAPSVPSFAPHFIQGGPFPLPYPGPGGYLDMGSKPMY
uniprot
proteins
function
FUNCTION: T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia. {ECO:0000269|PubMed:15545628, ECO:0000269|PubMed:18575602, ECO:0000269|PubMed:21331042, ECO:0000269|PubMed:9490412}.
uniprot
proteins
mass_dalton
47006
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the complex made of the adapter SMAD6 and the E3 ligase SMURF1, leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q13950}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15545628
uniprot
proteins
pubmed
18575602
uniprot
proteins
pubmed
21331042
uniprot
proteins
pubmed
8878690
uniprot
proteins
pubmed
8954725
uniprot
proteins
pubmed
9490412
uniprot
proteins
sequence_length
436
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00201}.
uniprot
proteins