Scn3b
entrez
245956
canonical
uniprot
Q9JK00
canonical
ensembl
ENSRNOG00000057221
resolver
ensembl
ENSRNOG00055018065
resolver
ensembl
ENSRNOG00060020755
resolver
ensembl
ENSRNOG00065026353
resolver
ensp
ENSRNOP00000071448
resolver
ensp
ENSRNOP00000109471
resolver
ensp
ENSRNOP00055024638
resolver
ensp
ENSRNOP00060029579
resolver
ensp
ENSRNOP00065037286
resolver
enst
ENSRNOT00000087022
resolver
enst
ENSRNOT00000158727
resolver
enst
ENSRNOT00055030605
resolver
enst
ENSRNOT00060035949
resolver
enst
ENSRNOT00065045481
resolver
genesymbol
Scn3b
resolver
uniprot
A0ABK0LTM5
resolver
uniprot_entry
A0ABK0LTM5_RAT
resolver
uniprot_entry
SCN3B_RAT
resolver
amino_acid_sequence
MPAFNRLLPLASLVLIYWVRVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVEATTVVEWFYRPEGGKDFLIYEYRNGHQEVESPFQGRLQWNGSKDLQDVSITVLNVTLNDSGLYTCNVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLFIEMIYCYRKVSKAEEAAQENASDYLAIPSENKENSVVPVEE
uniprot
proteins
function
FUNCTION: Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (PubMed:10688874, PubMed:11922146). The accessory beta subunits participate in localization and functional modulation of the Nav channels (PubMed:10688874, PubMed:11470829, PubMed:11922146). Voltage-gated sodium channels regulatory subunit that modulates channel gating kinetics (PubMed:10688874, PubMed:11922146). Modulates the activity of SCN2A/Nav1.2, causing a hyperpolarizing shift in the voltage-dependence of inactivation and increasing the fraction of channels operating in the fast gating mode (PubMed:10688874, PubMed:11922146). Also able to induce unique persistent SCN2A/Nav1.2-mediated sodium currents (PubMed:11922146). Could modulate the activity of SCN10A/Nav1.8 (PubMed:14975698, PubMed:15178439). {ECO:0000269|PubMed:10688874, ECO:0000269|PubMed:11470829, ECO:0000269|PubMed:11922146, ECO:0000269|PubMed:14975698, ECO:0000269|PubMed:15178439}.
uniprot
proteins
mass_dalton
24799
uniprot
proteins
post_translational_modification
PTM: Intramolecular disulfide bonds favor the voltage-gated sodium channel oligomeric complex assembly. {ECO:0000250|UniProtKB:Q9NY72}.; PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q9NY72}.
uniprot
proteins
protein_family
Sodium channel auxiliary subunit SCN3B (TC 8.A.17) family
uniprot
proteins
pubmed
10688874
uniprot
proteins
pubmed
11470829
uniprot
proteins
pubmed
11922146
uniprot
proteins
pubmed
14975698
uniprot
proteins
pubmed
15178439
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
215
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9NY72}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9NY72}.
uniprot
proteins
transmembrane_region
TRANSMEM 157..178; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NY72
uniprot
proteins