Otud5
entrez
54644
canonical
uniprot
Q3U2S4
canonical
ensembl
ENSMUSG00000031154
resolver
ensp
ENSMUSP00000033494
resolver
ensp
ENSMUSP00000111330
resolver
ensp
ENSMUSP00000111332
resolver
enst
ENSMUST00000115666
resolver
genesymbol
Otud5
resolver
genesymbol_syn
DXImx46e
resolver
genesymbol_syn
Sfc7
resolver
uniprot
A2AES5
resolver
uniprot
Q3UE33
resolver
uniprot
Q91YL5
resolver
uniprot
Q9CV50
resolver
uniprot
Q9JIG6
resolver
uniprot_entry
A2AES5_MOUSE
resolver
uniprot_entry
OTUD5_MOUSE
resolver
uniprot_sec
Q3UE33
resolver
uniprot_sec
Q91YL5
resolver
uniprot_sec
Q9CV50
resolver
uniprot_sec
Q9JIG6
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by N-ethyl-maleimide (NEM). {ECO:0000250|UniProtKB:Q96G74}.
uniprot
proteins
amino_acid_sequence
MTILPKKKPPPPDADPANEPPPPGPLPPAPRRGAGVGVGGGGTGVGGGERDRDSGVVGARPRASPPPQGPLPGPPGALHRWALAVPPGAVAGPRPQQASPPPCGGPGGPGGGPGDALGATTAGVGAAGVVVGVGGTVGVGGCCSGPGHSKRRRQAPGVGAVGGASPEREEVGAGYNSEDEYEAAAARIEAMDPATVEQQEHWFEKALRDKKGFIIKQMKEDGACLFRAVADQVYGDQDMHEVVRKHCMDYLMKNADYFSNYVTEDFTTYINRKRKNNCHGNHIEMQAMAEMYNRPVEVYQYSTEPINTFHGIHQNEDEPIRVSYHRNIHYNSVVNPNKATIGVGLGLPSFKPGFAEQSLMKNAIKTSEESWIEQQMLEDKKRATDWEATNEAIEEQVARESYLQWLRDQEKQARQVRGPSQPRKASATCSSATAAASSGLEEWTSRSPRQRSSASSPEHPELHAELGIKPPSPGTVLALAKPPSPCAPGTSSQFSAGGDRATSPLVSLYPALECRALIQQMSPSAFGLNDWDDDEILASVLAVSQQEYLDSMKKNKVHREPPPDKS
uniprot
proteins
ec_number
3.4.19.12
uniprot
proteins
function
FUNCTION: Deubiquitinating enzyme that functions as a negative regulator of the innate immune system. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro). Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1. Acts as a positive regulator of mTORC1 and mTORC2 signaling following phosphorylation by MTOR: acts by mediating deubiquitination of BTRC, leading to its stability. {ECO:0000250|UniProtKB:Q96G74}.
uniprot
proteins
mass_dalton
60306
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-177 is required for deubiquitinating activity. Phosphorylation at Ser-323, Ser-332 and Ser-503 by MTOR promotes its activity. {ECO:0000250|UniProtKB:Q96G74}.
uniprot
proteins
protein_family
Peptidase C85 family
uniprot
proteins
pubmed
10857745
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
33523931
uniprot
proteins
sequence_length
566
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96G74}.
uniprot
proteins