Braf
entrez
109880
canonical
uniprot
P28028
canonical
ensembl
ENSMUSG00000002413
resolver
ensp
ENSMUSP00000002487
resolver
ensp
ENSMUSP00000267625
resolver
ensp
ENSMUSP00000267626
resolver
ensp
ENSMUSP00000267627
resolver
ensp
ENSMUSP00000267628
resolver
ensp
ENSMUSP00000267629
resolver
ensp
ENSMUSP00000267635
resolver
ensp
ENSMUSP00000345922
resolver
genesymbol
Braf
resolver
genesymbol_syn
B-raf
resolver
uniprot
E9QNG9
resolver
uniprot
F6SZ47
resolver
uniprot
Q3USE9
resolver
uniprot_entry
BRAF_MOUSE
resolver
uniprot_sec
E9QNG9
resolver
uniprot_sec
F6SZ47
resolver
uniprot_sec
Q3USE9
resolver
activity_regulation
ACTIVITY REGULATION: In quiescent cells, maintained in an inactive state via an intramolecular interaction between the protein kinase and N-terminal domains. Following mitogen-mediated cell activation, binds via its RGB domain to active HRAS (GTP-bound) which releases the inhibitory intramolecular interaction between the two domains. This allows the MAP2K1-mediated dimerization of KSR1 or KSR2, and BRAF which activates BRAF. {ECO:0000250|UniProtKB:P15056}.
uniprot
proteins
amino_acid_sequence
MAALSGGGGSSSGGGGGGGGGGGGGDGGGGAEQGQALFNGDMEPEAGAGAAASSAADPAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLLESLVFQTPTDASRNNPKSPQKPIVRVFLPNKQRTVVPARCGVTVRDSLKKALMMRGLIPECCAVYRIQDGEKKPIGWDTDISWLTGEELHVEVLENVPLTTHNFVRKTFFTLAFCDFCRKLLFQGFRCQTCGYKFHQRCSTEVPLMCVNYDQLDLLFVSKFFEHHPVPQEEASFPETALPSGSSSAPPSDSTGPQILTSPSPSKSIPIPQPFRPADEDHRNQFGQRDRSSSAPNVHINTIEPVNIDDLIRDQGFRGDGGSTTGLSATPPASLPGSLTNVKALQKSPGPQRERKSSSSSSSEDRSRMKTLGRRDSSDDWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLNVTAPTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRWSGSHQFEQLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLPKIHRSASEPSLNRAGFQTEDFSLYACASPKTPIQAGGYGGFPVH
uniprot
proteins
disease_involvement
DISEASE: Note=Participates in a chromosomal translocation that produces a Tif1a-BRAF (T18) oncogene originally isolated from a furfural-induced hepatoma.
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. Phosphorylates MAP2K1, and thereby activates the MAP kinase signal transduction pathway. Phosphorylates PFKFB2 (By similarity). May play a role in the postsynaptic responses of hippocampal neurons. {ECO:0000250|UniProtKB:P15056}.
uniprot
proteins
mass_dalton
82515
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-348 by SGK1 inhibits its activity (By similarity). Dephosphorylation of Ser-348 by the SHOC2-MRAS-PP1c (SMP) complex consisting of SHOC2, GTP-bound M-Ras/MRAS and the catalytic subunit of protein phosphatase 1 (PPP1CA, PPP1CB or PPP1CC); this relieves inactivation and stimulates kinase activity (By similarity). {ECO:0000250|UniProtKB:P15056}.; PTM: Methylation by PRMT5 decreases stability and kinase activity. {ECO:0000269|PubMed:21917714}.; PTM: Ubiquitinated by RNF149; which leads to proteasomal degradation. Polyubiquitinated at Lys-615 in response to EGF (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
RAF subfamily
uniprot
proteins
protein_family
TKL Ser/Thr protein kinase family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
2052597
uniprot
proteins
pubmed
21102438
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21917714
uniprot
proteins
sequence_length
751
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with RGS14 and RAF1 in both the cytoplasm and membranes. {ECO:0000250}.
uniprot
proteins