Ctnna1
entrez
12385
canonical
uniprot
P26231
canonical
ensembl
ENSMUSG00000037815
resolver
ensp
ENSMUSP00000049007
resolver
ensp
ENSMUSP00000314859
resolver
enst
ENSMUST00000042345
resolver
genesymbol
Ctnna1
resolver
genesymbol_syn
Catna1
resolver
uniprot
Q545R0
resolver
uniprot_entry
CTNA1_MOUSE
resolver
uniprot_entry
Q545R0_MOUSE
resolver
amino_acid_sequence
MTAVHAGNINFKWDPKSLEIRTLAVERLLEPLVTQVTTLVNTNSKGPSNKKRGRSKKAHVLAASVEQATENFLEKGDKIAKESQFLKEELVVAVEDVRKQGDLMKSAAGEFADDPCSSVKRGNMVRAARALLSAVTRLLILADMADVYKLLVQLKVVEDGILKLRNAGNEQDLGIQYKALKPEVDKLNIMAAKRQQELKDVGNRDQMAAARGILQKNVPILYTASQACLQHPDVAAYKANRDLIYKQLQQAVTGISNAAQATASDDAAQHQGGSGGELAYALNNFDKQIIVDPLSFSEERFRPSLEERLESIISGAALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMGNAGRKERSDALNSAIDKMTKKTRDLRRQLRKAVMDHVSDSFLETNVPLLVLIEAAKNGNEKEVKEYAQVFREHANKLIEVANLACSISNNEEGVKLVRMSASQLEALCPQVINAALALAAKPQSKLAQENMDLFKEQWEKQVRVLTDAVDDITSIDDFLAVSENHILEDVNKCVIALQEKDVDGLDRTAGAIRGRAARVIHVVTSEMDNYEPGVYTEKVLEATKLLSNTVMPRFTEQVEAAVEALSSDPAQPMDENEFIDASRLVYDGIRDIRKAVLMIRTPEELDDSDFETEDFDVRSRTSVQTEDDQLIAGQSARAIMAQLPQEQKAKIAEQVASFQEEKSKLDAEVSKWDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVISAAKKIAEAGSRMDKLGRTIADHCPDSACKQDLLAYLQRIALYCHQLNICSKVKAEVQNLGGELVVSGVDSAMSLIQAAKNLMNAVVQTVKASYVASTKYQKSQGMASLNLPAVSWKMKAPEKKPLVKREKQDETQTKIKRASQKKHVNPVQALSEFKAMDSI
uniprot
proteins
function
FUNCTION: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. Involved in the regulation of WWTR1/TAZ, YAP1 and TGFB1-dependent SMAD2 and SMAD3 nuclear accumulation (PubMed:21145499). May play a crucial role in cell differentiation. {ECO:0000269|PubMed:16325583, ECO:0000269|PubMed:21145499}.
uniprot
proteins
mass_dalton
100106
uniprot
proteins
mutagenesis
MUTAGEN 436; /note="L->P: Mice bearing this mutation exhibit several retinal pigment epithelium (RPE) anomalies, including pigmentary abnormalities, focal thickening, elevated lesions, and decreased light-activated responses. Mutant animals show dysmorphology in the form of RPE cell shedding and accumulation of large multinucleated RPE cells."; /evidence="ECO:0000269|PubMed:26691986"; MUTAGEN 641..658; /note="SDFETEDFDVRSRTSVQT->ADFETEDFDVRARAAVQA: No effect on cell aggregation or E-cadherin/catenin complex assembly. Decreases strength of cell-cell adhesion."; /evidence="ECO:0000269|PubMed:25653389"; MUTAGEN 641..658; /note="SDFETEDFDVRSRTSVQT->EDFETEDFDVREREEVQE: No effect on cell aggregation or E-cadherin/catenin complex assembly. Increases strength of cell-cell adhesion."; /evidence="ECO:0000269|PubMed:25653389"; MUTAGEN 641; /note="S->A: No effect on cell aggregation or E-cadherin/catenin complex assembly. Decreases strength of cell-cell adhesion."; /evidence="ECO:0000269|PubMed:25653389"; MUTAGEN 641; /note="S->E: No effect on cell aggregation or E-cadherin/catenin complex assembly. Increases strength of cell-cell adhesion."; /evidence="ECO:0000269|PubMed:25653389
uniprot
proteins
post_translational_modification
PTM: Sumoylated. {ECO:0000250|UniProtKB:P35221}.; PTM: Phosphorylation seems to contribute to the strength of cell-cell adhesion rather than to the basic capacity for cell-cell adhesion. {ECO:0000305|PubMed:25653389}.; PTM: Monoubiquitinated by UBE2O at multiple lysine residues leading to binding swith from beta-catenin to vinculin. {ECO:0000250|UniProtKB:P35221}.
uniprot
proteins
protein_family
Vinculin/alpha-catenin family
uniprot
proteins
pubmed
10026224
uniprot
proteins
pubmed
10882138
uniprot
proteins
pubmed
11907041
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16325582
uniprot
proteins
pubmed
16325583
uniprot
proteins
pubmed
18093941
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
1904011
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
1924379
uniprot
proteins
pubmed
21145499
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25653389
uniprot
proteins
pubmed
26691986
uniprot
proteins
pubmed
7982500
uniprot
proteins
sequence_length
906
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16325583}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P35221}. Cell membrane {ECO:0000269|PubMed:1924379}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000269|PubMed:16325583}. Cell junction {ECO:0000269|PubMed:16325583, ECO:0000269|PubMed:1924379}. Cytoplasm {ECO:0000250|UniProtKB:Q9PVF8}. Nucleus {ECO:0000250|UniProtKB:P35221}. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries. {ECO:0000269|PubMed:1924379}.
uniprot
proteins