P21263
uniprot
P21263
canonical
amino_acid_sequence
MEGCVGEESFQMWELNRRLEAYLTRVKTLEEQNQLLSAELGGLRAQSGDTSWRARADDELASLRILVDQRWREKLEAEVQRDNLAEELESVAGRCQQVRLARERTVQEAACSRRALEAEKNARGWLSTQAAELERELEALRAAHEEERAHLNAQAACAPRRPPAPPHGSPVRAPEVEDLARRLGEVWRGAVRDYQERVAHMESSLGQARERLSQAVRGARECRLEVQQLQADRDSLQERREALEQRLEGRWQDRLQATDKFQLAVEALEQEKQGLQSQIAQILEGGQQLAHLKMSLSLEVATYRTLLEAENSRLQTPGRGSQASLGFLDPKLKPNFLGIPEDQYLGSVLPALSPTSFPSPLPNTLETPVTAFLKTQEFLQARTPTLASTPIPPISEAPCPPNAEVRAQEVPLSLLQTQAPEPLWAEATVPSSSAILPELEEPGGKQQGHFPDDLTSLATTLNPHHPTLEAKDGESSGSRVSSIFQEDEGQIWELVEKEADIEVKVENSSAQKTQESGLDTEETQDSQGPLQKETLKALGEEPLMSLKIQNYETAGKENCNSSTEGHLGTLEGPEKEKQIPLKSLEEKNVESEKTLENGVPVLSELLGKEDTRTEDQELMSPKGTLKRFSSLGKESQEVVRPSKEGNLESWTAFKEESQHPLGFPGAEDQMLERLVEKEDQSFPRSPEEEDQEACRPLQKENQEPLGYEEAEGQILERLIEKESQESLRSPEEEDQEAGRSLQKGNQEPLGYEEAEGQILERLIEKESQESLRSAEEEDQEACRSLQKENQEPLGYEEAEDQILERLIEKESQESLRSPEEEDQEAGRSLQKENQEPLGYEEAEDQMLERLIEKESQESLKSPEENQRIGKPLERENQKSLRYLEENQETFVPLESRNQRPLRSLEVEEEEQRIVKPLEKVSQDSLGSLAEENVQPLRYLEEDNCINKSLLEDKTHKSLGSLEDRNGDSIIIPQESETQVSLRPPEEEDQRIVNHLEKESQEFSRSSEEEERVMERSLEGENHESLSSVEKEDQMVESQLEKESQDSGKSLEDESQETFGPLEKENAESLRSLAGQDQEEQKLEQETQQTLRAVGNEQMAVSPPEKVDPELPKPLGNDQEIARSLGKENQESLVSLKEKGIETVKSLETEIIEPLETAEEDLERRKSIDTQEPLWSTEVARETVEPPEDEPPGSLGSVDENRETLTSLEKESQELSSLGKWNVETRVEDSQQCLQVEEGLQEEQHQESLREVKQELPSSGNQQRWEDVVEGKAVGQEAPLATTGVGTEDKAELHLRGQGGEEEAAAEGELLQDIVGEAWSLGSSEPKEQRVPAEALDNLEGGALEVPVAQSMPEVTERDEDRAQAGEQDSIEVTLGLEAARTGLELEQEVVGLEDPRHFAREEAIPPSLGEESVKAKIAQGLEGPGKEPKEAGALDSGILELPKTSSEALECQGHEESESMEGWEEEEASLETSDHEGSDAPQPRPPETEEDEGAQAALTAPGPKLLEPCSPIPILTDAHELQPQAEGIQEAGWQPEAGSEALERVENEPEFGLGEIPEGLQDWEEGREESEADDLGETLPDSTPLGLYLRSPASPKWDLAGEQRLSPQGDAGKEDWGPAVPAAQGLSGPPEEEEEQGHGSDLSSEEFEDLGTEASLLPGVPKEVADHVGQVPPVLQPACWDQGGESDGFADEEESGEEGEEEDADEEGAESGAQWWGSGASGGGCKVQDIAQRGDPVQESVGVSGLWDDGLRGAAANVPALEMVSQDSAEPSGSEESESASLEGEEGQVTDHLDAPQEVTSMVPGVGDAFDIGGQSPNLDSEQVNGKMENGLEQAEGQVVLDGDEDQELLLQGQEVGALKVPLVASPVHLGPSQPLKFTLSGVDGDSWSSGED
uniprot
proteins
function
FUNCTION: Required for brain and eye development (By similarity). Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division. Required for survival, renewal and mitogen-stimulated proliferation of neural progenitor cells. {ECO:0000250, ECO:0000269|PubMed:12686602, ECO:0000269|PubMed:20510364}.
uniprot
proteins
mass_dalton
208797
uniprot
proteins
post_translational_modification
PTM: Constitutively phosphorylated. This increases during mitosis when the cytoplasmic intermediate filament network is reorganized. {ECO:0000269|PubMed:11278541}.
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
11278541
uniprot
proteins
pubmed
12686602
uniprot
proteins
pubmed
15966898
uniprot
proteins
pubmed
1689217
uniprot
proteins
pubmed
20510364
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
1893
uniprot
proteins