Iws1
entrez
73473
canonical
uniprot
Q8C1D8
canonical
ensembl
ENSMUSG00000024384
resolver
ensp
ENSMUSP00000025243
resolver
ensp
ENSMUSP00000148514
resolver
ensp
ENSMUSP00000297938
resolver
ensp
ENSMUSP00000297947
resolver
enst
ENSMUST00000212675
resolver
genesymbol
Iws1
resolver
genesymbol_syn
Iws1l
resolver
uniprot
A0A1D5RLV0
resolver
uniprot
Q3TQ25
resolver
uniprot
Q3UWB0
resolver
uniprot
Q6NVD1
resolver
uniprot
Q8BY73
resolver
uniprot
Q9D9H4
resolver
uniprot_entry
A0A1D5RLV0_MOUSE
resolver
uniprot_entry
IWS1_MOUSE
resolver
uniprot_sec
Q3TQ25
resolver
uniprot_sec
Q3UWB0
resolver
uniprot_sec
Q6NVD1
resolver
uniprot_sec
Q8BY73
resolver
uniprot_sec
Q9D9H4
resolver
amino_acid_sequence
MDSEYYSGDQSDDGGATPVQDERDSGSDGEDGVTEQHSGSDTGSVDHHSENETSDREDGLAKIHNGTDSENDEPSNANASDSESEELHRPKDSDSDSEEHAESPASDSENEPVNQHGSDSENEELLNGHASDSEKEEVSKHAASDSEAEDTLQPQVSESDSEDPPRPQASDSENEEPPKPRISDSESEELPKPRVSDSESEDPPRPQASDSESEELPKPRVSDSESEDPPRPQASDSESEELPKPRVSDSESEDPQKGPASDSEAEDASRHKEKPDSDDSDGENKREDSEVQNESDGHTDRKGLHSSDSEEEEPKRQKIDSDDDEEKEGDEEKVAKRKAAVLSDSEDDAGNASAKKSRVVCDADDSDSDVVSDKSGKRETTVASDSEEEAGKEESSVKKKEDKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKNETQLKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMCGKRRRNRDGGTFISDADDVVSAMIVKMNEAAEEDRQLNNQKKPALKKLTLLPTVVMHLKKQDLKETFIDSGVMSAIKEWLSPLPDRSLPALKIREELLKILQELPSVSQETLKHSGIGRAVMYLYKHPKESRSNKDMAGKLINEWSRPIFGLTSNYKGMTREEREQRDLEQMPQRRRLSSTGGQTPRRDLEKVLTGEEKALRPGDPGFCARARVPMPSNKDYVVRPKWNVEMESSRFQASSKKGISRLDKQMRKFTDIRKKSRSAHAVKISIEGNKMPL
uniprot
proteins
function
FUNCTION: Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
85248
uniprot
proteins
post_translational_modification
PTM: Phosphorylation increases its interaction with PSIP1. {ECO:0000250|UniProtKB:Q96ST2}.
uniprot
proteins
protein_family
IWS1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17184735
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
766
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00649}.
uniprot
proteins