Gtf2h2
entrez
294693
canonical
uniprot
A0JN27
canonical
ensembl
ENSRNOG00000018230
resolver
ensembl
ENSRNOG00055027191
resolver
ensembl
ENSRNOG00060026612
resolver
ensembl
ENSRNOG00065022496
resolver
ensp
ENSRNOP00000057895
resolver
ensp
ENSRNOP00055038624
resolver
ensp
ENSRNOP00060038283
resolver
ensp
ENSRNOP00065031085
resolver
enst
ENSRNOT00000061183
resolver
enst
ENSRNOT00055047004
resolver
enst
ENSRNOT00060046094
resolver
enst
ENSRNOT00065038375
resolver
genesymbol
Gtf2h2
resolver
uniprot_entry
TF2H2_RAT
resolver
amino_acid_sequence
MDEEPERTKRWEGGYERTWEILKEDESGSLKATIEDILFKAKRKRVFEHHGQVRLGMMRHLYVVVDGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNPISQIGIIVTKSKRAEKLTELSGNPRKHITSLKKAVDMTCHGEPSLYNSLSMAMQTLKHMPGHTSREVLIIFSSLTTCDPSNIYDLIKTLKTAKIRVSVIGLSAEVRVCTVLARETGGTYHVILDETHYKELLARHVSPPPASSGSECSLIRMGFPQHTIASLSDQDAKPSFSMAHLDNNSTEPGLTLGGYFCPQCRAKYCELPVECKICGLTLVSAPHLARSYHHLFPLDAFQEIPLEEYKGERFCYGCQGELKDQHVYVCTVCRNVFCVDCDVFVHDSLHCCPGCVHKIPTQSGV
uniprot
proteins
function
FUNCTION: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. The N-terminus of GTF2H2 interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter. {ECO:0000250|UniProtKB:Q13888}.
uniprot
proteins
mass_dalton
44703
uniprot
proteins
protein_family
GTF2H2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641100
uniprot
proteins
sequence_length
396
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13888}.
uniprot
proteins