CRNN
entrez
49860
canonical
uniprot
Q9UBG3
canonical
ensembl
ENSG00000143536
resolver
ensp
ENSP00000271835
resolver
enst
ENST00000271835
resolver
genesymbol
CRNN
resolver
genesymbol_syn
C1orf10
resolver
genesymbol_syn
DRC1
resolver
genesymbol_syn
PDRC1
resolver
genesymbol_syn
SEP53
resolver
hgnc
HGNC:1230
resolver
uniprot
B2RE60
resolver
uniprot
Q8N613
resolver
uniprot_entry
CRNN_HUMAN
resolver
uniprot_sec
B2RE60
resolver
uniprot_sec
Q8N613
resolver
amino_acid_sequence
MPQLLQNINGIIEAFRRYARTEGNCTALTRGELKRLLEQEFADVIVKPHDPATVDEVLRLLDEDHTGTVEFKEFLVLVFKVAQACFKTLSESAEGACGSQESGSLHSGASQELGEGQRSGTEVGRAGKGQHYEGSSHRQSQQGSRGQNRPGVQTQGQATGSAWVSSYDRQAESQSQERISPQIQLSGQTEQTQKAGEGKRNQTTEMRPERQPQTREQDRAHQTGETVTGSGTQTQAGATQTVEQDSSHQTGRTSKQTQEATNDQNRGTETHGQGRSQTSQAVTGGHAQIQAGTHTQTPTQTVEQDSSHQTGSTSTQTQESTNGQNRGTEIHGQGRSQTSQAVTGGHTQIQAGSHTETVEQDRSQTVSHGGAREQGQTQTQPGSGQRWMQVSNPEAGETVPGGQAQTGASTESGRQEWSSTHPRRCVTEGQGDRQPTVVGEEWVDDHSRETVILRLDQGNLHTSVSSAQGQDAAQSEEKRGITARELYSYLRSTKP
uniprot
proteins
disease_involvement
DISEASE: Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. {ECO:0000269|PubMed:19558548}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; DISEASE: Note=CRNN expression is increased in psoriasis patients suggesting a potential role in disease pathogenesis. {ECO:0000269|PubMed:30009832}.
uniprot
proteins
function
FUNCTION: Promotes cell proliferation, G1/S cell cycle progression and induces expression of the cell cycle regulator CCND1 (PubMed:30009832). Regulates proliferation induced by pro-inflammatory cytokine response via activation of NFKB1 and PI3K/AKT signaling pathways (PubMed:30009832). {ECO:0000269|PubMed:30009832}.
uniprot
proteins
mass_dalton
53533
uniprot
proteins
protein_family
S100-fused protein family
uniprot
proteins
pubmed
11056050
uniprot
proteins
pubmed
11606197
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15854041
uniprot
proteins
pubmed
15896671
uniprot
proteins
pubmed
16466100
uniprot
proteins
pubmed
16640557
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17289885
uniprot
proteins
pubmed
19558548
uniprot
proteins
pubmed
30009832
uniprot
proteins
sequence_length
495
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15854041, ECO:0000269|PubMed:16640557}. Note=Does not colocalize with TGM1.
uniprot
proteins