Gopc
entrez
94221
canonical
uniprot
Q8BH60
canonical
ensembl
ENSMUSG00000019861
resolver
ensp
ENSMUSP00000020008
resolver
ensp
ENSMUSP00000151773
resolver
genesymbol
Gopc
resolver
genesymbol_syn
Cal
resolver
uniprot
Q8BSV4
resolver
uniprot
Q920R1
resolver
uniprot
Q9ET11
resolver
uniprot_entry
GOPC_MOUSE
resolver
uniprot_sec
Q8BSV4
resolver
uniprot_sec
Q920R1
resolver
uniprot_sec
Q9ET11
resolver
amino_acid_sequence
MSAGGPCPAGAGGGPGGSSCPVGVSPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQTVSQINHKLEAQLVDLRSELTETQAEKVVLEKEVHEQLLQLHSTQLQLHAKTGQSVDSGAIKAKLSVHSVEDLERELEANKTEKVKEARLEAEVKLLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGSGNSGASCKDSSGEMKMLQGYNKKAVRDAHENGDVGAAGESPLDDTAARAAHLHSLHQKKAY
uniprot
proteins
function
FUNCTION: Plays a role in intracellular protein trafficking and degradation (PubMed:12149515). May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (PubMed:15317815). May also regulate the intracellular trafficking of the ADR1B receptor (By similarity). May play a role in autophagy (PubMed:12372286). Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR (By similarity). Overexpression results in CFTR intracellular retention and degradation in the lysosomes (By similarity). {ECO:0000250|UniProtKB:Q9HD26, ECO:0000269|PubMed:12149515, ECO:0000269|PubMed:12372286, ECO:0000269|PubMed:15317815}.
uniprot
proteins
mass_dalton
50662
uniprot
proteins
pubmed
11162552
uniprot
proteins
pubmed
11384996
uniprot
proteins
pubmed
11520064
uniprot
proteins
pubmed
12149515
uniprot
proteins
pubmed
12372286
uniprot
proteins
pubmed
12471024
uniprot
proteins
pubmed
12885772
uniprot
proteins
pubmed
15136571
uniprot
proteins
pubmed
15317815
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28339613
uniprot
proteins
sequence_length
463
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Synapse. Postsynaptic density. Cell projection, dendrite. Note=Enriched in synaptosomal and postsynaptic densities (PSD) fractions. Expressed in cell bodies and dendrites of Purkinje cells. Localized at the trans-Golgi network (TGN) of spermatids and the medulla of round spermatides.
uniprot
proteins