Edar
entrez
13608
canonical
uniprot
Q9R187
canonical
ensembl
ENSMUSG00000003227
resolver
ensp
ENSMUSP00000003312
resolver
enst
ENSMUST00000003312
resolver
genesymbol
Edar
resolver
genesymbol_syn
Dl
resolver
uniprot
Q9DC43
resolver
uniprot_entry
EDAR_MOUSE
resolver
uniprot_sec
Q9DC43
resolver
amino_acid_sequence
MAHVGDCKWMSWLPVLVVSLMCSAKAEDSNCGENEYHNQTTGLCQQCPPCRPGEEPYMSCGYGTKDDDYGCVPCPAEKFSKGGYQICRRHKDCEGFFRATVLTPGDMENDAECGPCLPGYYMLENRPRNIYGMVCYSCLLAPPNTKECVGATSGVSAHSSSTSGGSTLSPFQHAHKELSGQGHLATALIIAMSTIFIMAIAIVLIIMFYIMKTKPSAPACCSSPPGKSAEAPANTHEEKKEAPDSVVTFPENGEFQKLTATPTKTPKSENDASSENEQLLSRSVDSDEEPAPDKQGSPELCLLSLVHLAREKSVTSNKSAGIQSRRKKILDVYANVCGVVEGLSPTELPFDCLEKTSRMLSSTYNSEKAVVKTWRHLAESFGLKRDEIGGMTDGMQLFDRISTAGYSIPELLTKLVQIERLDAVESLCADILEWAGVVPPASPPPAAS
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Edar are a cause of the downless phenotype in mice (the equivalent of anhidrotic ectodermal dysplasia in humans). The disease is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands.
uniprot
proteins
function
FUNCTION: Receptor for EDA isoform TAA, but not for EDA isoform TA-2 (By similarity). May mediate the activation of NF-kappa-B and JNK. May promote caspase-independent cell death. {ECO:0000250}.
uniprot
proteins
mass_dalton
48434
uniprot
proteins
pubmed
10431242
uniprot
proteins
pubmed
11203701
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
448
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 188..208; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins