CDK14
entrez
5218
canonical
uniprot
O94921
canonical
ensembl
ENSG00000058091
resolver
ensp
ENSP00000265741
resolver
ensp
ENSP00000369390
resolver
ensp
ENSP00000385034
resolver
ensp
ENSP00000398936
resolver
enst
ENST00000436577
resolver
genesymbol
CDK14
resolver
genesymbol_syn
KIAA0834
resolver
genesymbol_syn
PFTK1
resolver
hgnc
HGNC:8883
resolver
uniprot
A4D1E6
resolver
uniprot
A6NK51
resolver
uniprot
A8WFP6
resolver
uniprot
B4DHG5
resolver
uniprot
B4DK59
resolver
uniprot
B4DNM2
resolver
uniprot
E7EUK8
resolver
uniprot
Q75N06
resolver
uniprot
Q75N22
resolver
uniprot
Q8N764
resolver
uniprot
Q9H3D7
resolver
uniprot
Q9UDR0
resolver
uniprot_entry
B4DK59_HUMAN
resolver
uniprot_entry
CDK14_HUMAN
resolver
uniprot_entry
E7EUK8_HUMAN
resolver
uniprot_sec
A4D1E6
resolver
uniprot_sec
A6NK51
resolver
uniprot_sec
A8WFP6
resolver
uniprot_sec
B4DHG5
resolver
uniprot_sec
B4DNM2
resolver
uniprot_sec
Q75N06
resolver
uniprot_sec
Q75N22
resolver
uniprot_sec
Q8N764
resolver
uniprot_sec
Q9H3D7
resolver
uniprot_sec
Q9UDR0
resolver
activity_regulation
ACTIVITY REGULATION: Serine/threonine-protein kinase activity is promoted by associated cyclins CCDN3 and CCNY and repressed by CDKN1A.
uniprot
proteins
amino_acid_sequence
MCDLIEPQPAEKIGKMKKLRRTLSESFSRIALKKDDTTFDEICVTKMSTRNCQGMDSVIKPLDTIPEDKKVRVQRTQSTFDPFEKPANQVKRVHSENNACINFKTSSTGKESPKVRRHSSPSSPTSPKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIHTKETLTLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPERFTLYSSKNLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQPEAGESMRAFGKNNSYGKSLSNSKH
uniprot
proteins
ec_number
2.7.11.22
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport. {ECO:0000269|PubMed:16461467, ECO:0000269|PubMed:17517622, ECO:0000269|PubMed:19524571, ECO:0000269|PubMed:20059949}.
uniprot
proteins
mass_dalton
53057
uniprot
proteins
mutagenesis
MUTAGEN 164; /note="K->R: Abolishes protein kinase activity."; /evidence="ECO:0000269|PubMed:17517622, ECO:0000269|PubMed:19524571
uniprot
proteins
protein_family
CDC2/CDKX subfamily
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10048485
uniprot
proteins
pubmed
11313143
uniprot
proteins
pubmed
12098780
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16461467
uniprot
proteins
pubmed
16775625
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17517622
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19524571
uniprot
proteins
pubmed
20059949
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27821587
uniprot
proteins
sequence_length
469
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Cytoplasm. Nucleus. Note=Recruited to the cell membrane by CCNY.
uniprot
proteins