Tyw2
entrez
314999
canonical
uniprot
Q4V8B8
canonical
ensembl
ENSRNOG00000008978
resolver
ensembl
ENSRNOG00065005057
resolver
ensp
ENSRNOP00000011874
resolver
ensp
ENSRNOP00065005159
resolver
enst
ENSRNOT00000011876
resolver
enst
ENSRNOT00065007412
resolver
genesymbol
Tyw2
resolver
genesymbol_syn
Trmt12
resolver
uniprot
Q6AXV3
resolver
uniprot_entry
TYW2_RAT
resolver
uniprot_sec
Q6AXV3
resolver
amino_acid_sequence
MERECEKSVVVAVVTEPRFTQRYRDYLEKQKLLDRQYRVEKLRDGTVALPVLAETLSEHHLQELKNRVAPGSTCKLTQLLDPLPSKKARVCSPAQRLCLEVRRWVEDRGVTWSTELEADLPRSWQRHGDLMLLSEDCFQATQWKRLEPELWETVASALGVQRLAKRGRVLPDGTRTPTVTLLLGDHGWVEHVDNGIRYKFDVTQCMFSFGNITEKLRVASLSCAGEVLVDLYAGIGYFTLPFLVHAGAAFVHACEWNPHAVVALRKNLEINGVADRCQIHFGDNRKLKLSNTADRVNLGLIPSSEEGWPIACQVLRKDVGGILHIHQNVESFSGKNPQPPGSSNMEKKHWPHPQKITTDKQGNRTTGSCMGEMSSASKPEWQRWAESAESQIASLLHQVHGKPWRTRILHVHPVKSYAPHVDHIVLDLECRPCPLVG
uniprot
proteins
ec_number
2.5.1.114
uniprot
proteins
function
FUNCTION: S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86. {ECO:0000250|UniProtKB:Q53H54}.
uniprot
proteins
mass_dalton
49387
uniprot
proteins
pathway_participation
PATHWAY: tRNA modification; wybutosine-tRNA(Phe) biosynthesis. {ECO:0000250|UniProtKB:Q53H54}.
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
TRM5/TYW2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
437
uniprot
proteins