Slc35d3
entrez
76157
canonical
uniprot
Q8BGF8
canonical
ensembl
ENSMUSG00000050473
resolver
ensp
ENSMUSP00000060589
resolver
ensp
ENSMUSP00000317606
resolver
enst
ENSMUST00000059805
resolver
genesymbol
Slc35d3
resolver
genesymbol_syn
Frcl1
resolver
uniprot
B9EI54
resolver
uniprot
Q9CXD4
resolver
uniprot_entry
B9EI54_MOUSE
resolver
uniprot_entry
S35D3_MOUSE
resolver
uniprot_sec
Q9CXD4
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by proton uncouplers that directly abolish the proton electrochemical gradient. {ECO:0000250|UniProtKB:Q5M8T2}.
uniprot
proteins
amino_acid_sequence
MRQLCRGRVLGISVAIAHGVFSGSLNILLKFLISRYQFSFLTLVQCLTSSTAALSLELLRRLGLIAVPPFGLSLARSFAGVAVLSTLQSSLTLWSLRGLSLPMYVVFKRCLPLVTMLIGVLVLKNGAPSPGVLAAVLITTCGAALAGAGDLTGDPIGYVTGVLAVLVHAAYLVLIQKASADTEHGPLTAQYVIAVSATPLLVICSFASTDSIHAWTFPGWKDPAMVSIFVACILIGCAMNFTTLHCTYINSAVTTSFVGVVKSIATITVGMVAFSDVEPTSLFIAGVVVNTLGSIIYCVAKFLETRRQSNYEDLESQAEGEERQPSGDQLPFVMEELPAKSGNSEPESAEGAGDSVQQGGQESRGSIRGISLAARSSRAEGHSDEVGRRSLKDTYLEVWRLVRGTKYMKKDYLMENEALPSP
uniprot
proteins
function
FUNCTION: Probable UDP-glucose transmembrane transporter involved in UDP-glucose transport from the cytosol to the lumen of synaptic vesicles (PubMed:34269178). It is involved in platelet dense granules maturation (PubMed:17062724, PubMed:22611153). {ECO:0000269|PubMed:17062724, ECO:0000269|PubMed:22611153, ECO:0000269|PubMed:34269178}.; FUNCTION: Alternatively, could function as a molecular adapter enhancing the formation of the PI3KC3-C1/AIC/autophagy initiation complex to promote autophagy in dopaminergic neurons (PubMed:27171858). Could also regulate the plasma membrane localization of the D(1A) dopamine receptor/DRD1 and dopamine signaling (PubMed:24550737). {ECO:0000269|PubMed:24550737, ECO:0000269|PubMed:27171858}.
uniprot
proteins
mass_dalton
44917
uniprot
proteins
protein_family
SLC35D subfamily
uniprot
proteins
protein_family
TPT transporter family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17062724
uniprot
proteins
pubmed
22611153
uniprot
proteins
pubmed
24550737
uniprot
proteins
pubmed
27171858
uniprot
proteins
pubmed
34269178
uniprot
proteins
sequence_length
422
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q5M8T2}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:22611153}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:24550737}; Multi-pass membrane protein {ECO:0000255}. Note=Active at early endosome membrane in the biosynthesis of mature platelet-dense granules. {ECO:0000269|PubMed:22611153}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 38..58; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 64..84; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 103..123; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 131..151; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 155..175; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 187..207; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 224..244; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 257..277; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 280..300; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins