P2RX5
entrez
5026
canonical
uniprot
Q93086
canonical
ensembl
ENSG00000083454
resolver
ensembl
ENSG00000257950
resolver
ensp
ENSP00000225328
resolver
ensp
ENSP00000342161
resolver
ensp
ENSP00000447545
resolver
ensp
ENSP00000448355
resolver
genesymbol
P2RX5
resolver
genesymbol_syn
P2X5
resolver
genesymbol_syn
P2X5FL
resolver
hgnc
HGNC:8536
resolver
uniprot
A0A8V8TLD3
resolver
uniprot
G5E981
resolver
uniprot
O43450
resolver
uniprot
O75540
resolver
uniprot
Q308M5
resolver
uniprot
Q59F38
resolver
uniprot
Q8IXW4
resolver
uniprot
Q93087
resolver
uniprot
Q9NZV0
resolver
uniprot_entry
P2RX5_HUMAN
resolver
uniprot_sec
A0A8V8TLD3
resolver
uniprot_sec
G5E981
resolver
uniprot_sec
O43450
resolver
uniprot_sec
O75540
resolver
uniprot_sec
Q308M5
resolver
uniprot_sec
Q59F38
resolver
uniprot_sec
Q8IXW4
resolver
uniprot_sec
Q93087
resolver
uniprot_sec
Q9NZV0
resolver
activity_regulation
ACTIVITY REGULATION: Activated by ATP (PubMed:12761352). Slowly desensitizing (PubMed:12761352). Sensitive to the ATP agonist alpha/beta-methylene-ATP (PubMed:12761352). {ECO:0000269|PubMed:12761352}.
uniprot
proteins
amino_acid_sequence
MGQAGCKGLCLSLFDYKTEKYVIAKNKKVGLLYRLLQASILAYLVVWVFLIKKGYQDVDTSLQSAVITKVKGVAFTNTSDLGQRIWDVADYVIPAQGENVFFVVTNLIVTPNQRQNVCAENEGIPDGACSKDSDCHAGEAVTAGNGVKTGRCLRRENLARGTCEIFAWCPLETSSRPEEPFLKEAEDFTIFIKNHIRFPKFNFSKSNVMDVKDRSFLKSCHFGPKNHYCPIFRLGSVIRWAGSDFQDIALEGGVIGINIEWNCDLDKAASECHPHYSFSRLDNKLSKSVSSGYNFRFARYYRDAAGVEFRTLMKAYGIRFDVMVNGKAGKFSIIPTIINVGSGVALMGAGAFFCDLVLIYLIKKREFYRDKKYEEVRGLEDSSQEAEDEASGLGLSEQLTSGPGLLGMPEQQELQEPPEAKRGSSSQKGNGSVCPQLLEPHRST
uniprot
proteins
function
FUNCTION: [Isoform 6]: ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (PubMed:12761352). Unlike other P2RX receptors, the P2X5 receptor is also permeable to chloride (PubMed:12761352). May play a supporting role in the inflammatory response (By similarity). {ECO:0000250|UniProtKB:Q91VE2, ECO:0000269|PubMed:12761352}.; FUNCTION: [Isoform 1]: Non-functional. {ECO:0000269|PubMed:9414125}.
uniprot
proteins
mass_dalton
49303
uniprot
proteins
mutagenesis
MUTAGEN 355; /note="D->L: Impairs homotrimerization."; /evidence="ECO:0000269|PubMed:17001079
uniprot
proteins
protein_family
P2X receptor family
uniprot
proteins
pubmed
10673275
uniprot
proteins
pubmed
12761352
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17001079
uniprot
proteins
pubmed
20223879
uniprot
proteins
pubmed
9414125
uniprot
proteins
sequence_length
444
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 6]: Cell membrane {ECO:0000269|PubMed:17001079, ECO:0000269|PubMed:20223879}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P56373}. Note=The absence of the exon 10-encoded amino acids substantially results in subunit aggregation and retention in the cell cytoplasm. {ECO:0000269|PubMed:17001079}.
uniprot
proteins
transmembrane_region
TRANSMEM 31..51; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P56373"; TRANSMEM 320..362; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P56373
uniprot
proteins