PIM3
entrez
415116
canonical
uniprot
Q86V86
canonical
ensembl
ENSG00000198355
resolver
ensp
ENSP00000353824
resolver
enst
ENST00000360612
resolver
genesymbol
PIM3
resolver
hgnc
HGNC:19310
resolver
uniprot
A5D8X8
resolver
uniprot
A8K7J0
resolver
uniprot
B1B0P0
resolver
uniprot
Q68BM2
resolver
uniprot_entry
PIM3_HUMAN
resolver
uniprot_sec
A5D8X8
resolver
uniprot_sec
A8K7J0
resolver
uniprot_sec
B1B0P0
resolver
uniprot_sec
Q68BM2
resolver
amino_acid_sequence
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth. {ECO:0000269|PubMed:15540201, ECO:0000269|PubMed:16818649, ECO:0000269|PubMed:17270021, ECO:0000269|PubMed:17876606, ECO:0000269|PubMed:18593906}.
uniprot
proteins
mass_dalton
35891
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, leading to proteasomal degradation. {ECO:0000269|PubMed:12473674}.; PTM: Phosphorylated. Interaction with PPP2CA promotes dephosphorylation. {ECO:0000269|PubMed:12473674}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
PIM subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
12473674
uniprot
proteins
pubmed
12798037
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15540201
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16818649
uniprot
proteins
pubmed
17270021
uniprot
proteins
pubmed
17876606
uniprot
proteins
pubmed
18593906
uniprot
proteins
sequence_length
326
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17876606}.
uniprot
proteins