Rfk
entrez
54391
canonical
uniprot
Q8CFV9
canonical
ensembl
ENSMUSG00000024712
resolver
ensp
ENSMUSP00000025617
resolver
enst
ENSMUST00000025617
resolver
genesymbol
Rfk
resolver
uniprot
O35471
resolver
uniprot
O35472
resolver
uniprot
Q9CQ95
resolver
uniprot_entry
RIFK_MOUSE
resolver
uniprot_sec
O35471
resolver
uniprot_sec
O35472
resolver
uniprot_sec
Q9CQ95
resolver
amino_acid_sequence
MRSLPFFCRGQVVRGFGRGSKQLGIPTANFPEQVVDNLPADVSTGIYYGWASVGSGDVHKMVVSIGWNPYYKNVKKSMETHIIHTFKEDFYGEILNVAIVGYLRPEKNFDSLESLISAIQGDIEEAKKQLDLPEHLKLKDDNFFQVSKGKIMNGH
uniprot
proteins
ec_number
2.7.1.26
uniprot
proteins
function
FUNCTION: Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase (By similarity). {ECO:0000250|UniProtKB:Q969G6}.
uniprot
proteins
mass_dalton
17437
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1. {ECO:0000250|UniProtKB:Q969G6}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19641494
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
155
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins