Fcn1
entrez
14133
canonical
uniprot
O70165
canonical
ensembl
ENSMUSG00000026938
resolver
ensp
ENSMUSP00000028307
resolver
ensp
ENSMUSP00000273299
resolver
ensp
ENSMUSP00000349368
resolver
enst
ENSMUST00000028307
resolver
genesymbol
Fcn1
resolver
genesymbol
Fcna
resolver
genesymbol_syn
Fcna
resolver
uniprot
Q4FJM1
resolver
uniprot_entry
FCN1_MOUSE
resolver
uniprot_entry
Q4FJM1_MOUSE
resolver
amino_acid_sequence
MQWPTLWAFSGLLCLCPSQALGQERGACPDVKVVGLGAQDKVVVIQSCPGFPGPPGPKGEPGSPAGRGERGFQGSPGKMGPAGSKGEPGTMGPPGVKGEKGDTGAAPSLGEKELGDTLCQRGPRSCKDLLTRGIFLTGWYTIHLPDCRPLTVLCDMDVDGGGWTVFQRRVDGSIDFFRDWDSYKRGFGNLGTEFWLGNDYLHLLTANGNQELRVDLQDFQGKGSYAKYSSFQVSEEQEKYKLTLGQFLEGTAGDSLTKHNNMSFTTHDQDNDANSMNCAALFHGAWWYHNCHQSNLNGRYLSGSHESYADGINWGTGQGHHYSYKVAEMKIRAS
uniprot
proteins
function
FUNCTION: Extracellular lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Specifically recognizes and binds carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway. Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8. {ECO:0000250|UniProtKB:O00602}.
uniprot
proteins
mass_dalton
36298
uniprot
proteins
protein_family
Ficolin lectin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17669269
uniprot
proteins
pubmed
9535745
uniprot
proteins
sequence_length
334
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:O00602}. Cell surface {ECO:0000250|UniProtKB:O00602}. Note=Specifically binds carbohydrates on the surface of pathogens. Found on the monocyte and granulocyte surface. {ECO:0000250|UniProtKB:O00602}.
uniprot
proteins