Nek7
entrez
59125
canonical
uniprot
Q9ES74
canonical
ensembl
ENSMUSG00000026393
resolver
ensp
ENSMUSP00000027642
resolver
ensp
ENSMUSP00000140635
resolver
ensp
ENSMUSP00000140903
resolver
enst
ENSMUST00000027642
resolver
enst
ENSMUST00000186017
resolver
enst
ENSMUST00000187407
resolver
genesymbol
Nek7
resolver
uniprot
A0A0R4J068
resolver
uniprot
Q3TN15
resolver
uniprot
Q3UEV7
resolver
uniprot_entry
A0A0R4J068_MOUSE
resolver
uniprot_entry
NEK7_MOUSE
resolver
uniprot_entry
Q3TN15_MOUSE
resolver
uniprot_sec
Q3UEV7
resolver
activity_regulation
ACTIVITY REGULATION: Binding to NEK9 stimulates its activity by releasing the autoinhibitory function of Tyr-97. {ECO:0000250|UniProtKB:Q8TDX7}.
uniprot
proteins
amino_acid_sequence
MDEQSQGMQGPPVTQFQPQKALRPDMGYNTLANFRIEKKIGRGQFSEVYRASCLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALDHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNICINPDPEKRPDIAYVYDVAKRMHACTAST
uniprot
proteins
ec_number
2.7.11.34
uniprot
proteins
function
FUNCTION: Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:20473324). Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis (PubMed:20473324). Phosphorylates EML4 at 'Ser-146', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (By similarity). Phosphorylates RPS6KB1 (By similarity). Acts as an essential activator of the NLRP3 inflammasome assembly independently of its kinase activity (PubMed:26642356, PubMed:26814970). Acts by unlocking NLRP3 following NLRP3 tranlocation into the microtubule organizing center (MTOC), relieving NLRP3 autoinhibition and promoting formation of the NLRP3:PYCARD complex, and activation of CASP1 (PubMed:26553871, PubMed:26642356, PubMed:26814970). Serves as a cellular switch that enforces mutual exclusivity of the inflammasome response and cell division: interaction with NEK9 prevents interaction with NLRP3 and activation of the inflammasome during mitosis (PubMed:26642356, PubMed:26814970). {ECO:0000250|UniProtKB:D3ZBE5, ECO:0000250|UniProtKB:Q8TDX7, ECO:0000269|PubMed:20473324, ECO:0000269|PubMed:26553871, ECO:0000269|PubMed:26642356, ECO:0000269|PubMed:26814970}.
uniprot
proteins
mass_dalton
34537
uniprot
proteins
mutagenesis
MUTAGEN 63..64; /note="KK->MM: No effect on interaction with NLRP3."; /evidence="ECO:0000269|PubMed:26814970"; MUTAGEN 63; /note="K->M: No effect on interaction with NLRP3."; /evidence="ECO:0000269|PubMed:26814970"; MUTAGEN 64; /note="K->M: No effect on interaction with NLRP3."; /evidence="ECO:0000269|PubMed:26814970
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-195 required for its activation. {ECO:0000250|UniProtKB:Q8TDX7}.
uniprot
proteins
protein_family
NEK Ser/Thr protein kinase family
uniprot
proteins
protein_family
NIMA subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10964517
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20473324
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26188091
uniprot
proteins
pubmed
26553871
uniprot
proteins
pubmed
26642356
uniprot
proteins
pubmed
26814970
uniprot
proteins
sequence_length
302
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26188091}. Cytoplasm {ECO:0000269|PubMed:26188091}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q8TDX7}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q8TDX7}. Note=Present at centrosome throughout the cell cycle (By similarity). Also detected at spindle midzone of the anaphase cells and eventually concentrates at the midbody (By similarity). Interaction with ANKS3 prevents its translocation to the nucleus (PubMed:26188091). {ECO:0000250|UniProtKB:Q8TDX7, ECO:0000269|PubMed:26188091}.
uniprot
proteins