Dgkg
entrez
110197
canonical
uniprot
Q91WG7
canonical
ensembl
ENSMUSG00000022861
resolver
ensp
ENSMUSP00000023578
resolver
ensp
ENSMUSP00000087371
resolver
ensp
ENSMUSP00000167405
resolver
ensp
ENSMUSP00000167413
resolver
enst
ENSMUST00000023578
resolver
enst
ENSMUST00000089925
resolver
genesymbol
Dgkg
resolver
genesymbol_syn
Dagk3
resolver
genesymbol_syn
mKIAA4131
resolver
uniprot
F6ZND5
resolver
uniprot
Q570Z5
resolver
uniprot
Q8C413
resolver
uniprot_entry
DGKG_MOUSE
resolver
uniprot_entry
F6ZND5_MOUSE
resolver
uniprot_entry
Q570Z5_MOUSE
resolver
uniprot_entry
Q8C413_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: The activity is calcium-dependent (By similarity). Requires phosphatidylserine for maximal activity (By similarity). {ECO:0000250|UniProtKB:P49619, ECO:0000250|UniProtKB:P49620}.
uniprot
proteins
amino_acid_sequence
MSEEQWVSLSSEEFDQLQKYSEYSSKKIKDVLAEFNEGGSLRQYDPHKPISYDVFKLFMRAYLEVDLPQPLSTHLFLAFSQKPRQETPDHPKEGASSSEPNVSDYNSDNAAKADEACAPDTESKTTKTQAPSKELEAAAPWEDPGALASSSDAPVVYLKDVVCYLSLMETGRPQDKLEFMFRLYDSDENGLLDQAEMDQIVSQMLHVAQYLEWDPTELRPILKEMLQGMDYDKDGFVSLQEWINGGMTTIPLLVLLGMDDSGSKGDGRHAWTLKHFKKPTYCNFCRAMLMGVGKQGLCCIYCKYTVHQRCVSKTIHGCVKTNSKAKRSGEVMQHAWVEGNSSVKCDRCHKSIKCYQSVTARHCVWCRMTFHRKCELSTVCDGGELKDHILLPTSICPVSGDRQGGKSDGSVAAKGELVTQYKIIPSPGTHPLLVLVNPKSGGRQGERILRKFHYLLNPEQVFNLDNGGPTPGLNFFHDTPDFRVLACGGDGTVGWILDCIDKANFTKHPPVAVLPLGTGNDLARCLRWGGGYEGGSLTKILKEIEQSPLVMLDRWYLEVMPREEVENGDQVPYNIMNNYFSIGVDASIAHRFHMMREKHPEKFNSRMKNKLWYFEFGTSETFAATCKKLHDHIELECDGVEVDLSNIFLEGIAILNIPSMYGGTNLWGETKKNRAVIRESRKSVTDPKELKCCVQDLSDQLLEVVGLEGAMEMGQIYTGLKSAGRRLAQCSSVTIRTNKLLPMQVDGEPWMQPQCTIKITHKNQAPMMMGPPQKSSFFSLRRKSRSKD
uniprot
proteins
ec_number
2.7.1.107
uniprot
proteins
function
FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:32033984). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:32033984). Has no apparent specificity with regard to the acyl compositions of diacylglycerol (By similarity). Specifically expressed in the cerebellum where it controls the level of diacylglycerol which in turn regulates the activity of protein kinase C gamma (PubMed:32033984). Through protein kinase C gamma, indirectly regulates the dendritic development of Purkinje cells, cerebellar long term depression and ultimately cerebellar motor coordination (PubMed:32033984). {ECO:0000250|UniProtKB:P49619, ECO:0000269|PubMed:32033984}.
uniprot
proteins
mass_dalton
88523
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; glycerolipid metabolism. {ECO:0000269|PubMed:32033984}.
uniprot
proteins
protein_family
Eukaryotic diacylglycerol kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32033984
uniprot
proteins
sequence_length
788
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P49620}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P49619}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P49620}.
uniprot
proteins