DDX20
entrez
11218
canonical
uniprot
Q9UHI6
canonical
ensembl
ENSG00000064703
resolver
ensp
ENSP00000358716
resolver
genesymbol
DDX20
resolver
genesymbol_syn
DP103
resolver
genesymbol_syn
GEMIN3
resolver
hgnc
HGNC:2743
resolver
uniprot
B4DWV7
resolver
uniprot
Q96F72
resolver
uniprot
Q9H4N4
resolver
uniprot
Q9NVM3
resolver
uniprot
Q9UF59
resolver
uniprot
Q9UIY0
resolver
uniprot
Q9Y659
resolver
uniprot_entry
DDX20_HUMAN
resolver
uniprot_entry
Q9H4N4_HUMAN
resolver
uniprot_sec
B4DWV7
resolver
uniprot_sec
Q96F72
resolver
uniprot_sec
Q9NVM3
resolver
uniprot_sec
Q9UF59
resolver
uniprot_sec
Q9UIY0
resolver
uniprot_sec
Q9Y659
resolver
amino_acid_sequence
MAAAFEASGALAAVATAMPAEHVAVQVPAPEPTPGPVRILRTAQDLSSPRTRTGDVLLAEPADFESLLLSRPVLEGLRAAGFERPSPVQLKAIPLGRCGLDLIVQAKSGTGKTCVFSTIALDSLVLENLSTQILILAPTREIAVQIHSVITAIGIKMEGLECHVFIGGTPLSQDKTRLKKCHIAVGSPGRIKQLIELDYLNPGSIRLFILDEADKLLEEGSFQEQINWIYSSLPASKQMLAVSATYPEFLANALTKYMRDPTFVRLNSSDPSLIGLKQYYKVVNSYPLAHKVFEEKTQHLQELFSRIPFNQALVFSNLHSRAQHLADILSSKGFPAECISGNMNQNQRLDAMAKLKHFHCRVLISTDLTSRGIDAEKVNLVVNLDVPLDWETYMHRIGRAGRFGTLGLTVTYCCRGEEENMMMRIAQKCNINLLPLPDPIPSGLMEECVDWDVEVKAAVHTYGIASVPNQPLKKQIQKIERTLQIQKAHGDHMASSRNNSVSGLSVKSKNNTKQKLPVKSHSECGIIEKATSPKELGCDRQSEEQMKNSVQTPVENSTNSQHQVKEALPVSLPQIPCLSSFKIHQPYTLTFAELVEDYEHYIKEGLEKPVEIIRHYTGPGDQTVNPQNGFVRNKVIEQRVPVLASSSQSGDSESDSDSYSSRTSSQSKGNKSYLEGSSDNQLKDSESTPVDDRISLEQPPNGSDTPNPEKYQESPGIQMKTRLKEGASQRAKQSRRNLPRRSSFRLQTEAQEDDWYDCHREIRLSFSDTYQDYEEYWRAYYRAWQEYYAAASHSYYWNAQRHPSWMAAYHMNTIYLQEMMHSNQ
uniprot
proteins
ec_number
3.6.1.15
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. May also play a role in the metabolism of small nucleolar ribonucleoprotein (snoRNPs). {ECO:0000269|PubMed:18984161}.
uniprot
proteins
mass_dalton
92241
uniprot
proteins
protein_family
DDX20 subfamily
uniprot
proteins
protein_family
DEAD box helicase family
uniprot
proteins
pubmed
10383418
uniprot
proteins
pubmed
10601333
uniprot
proteins
pubmed
12095920
uniprot
proteins
pubmed
12668731
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16153597
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17178713
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
18984161
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20510246
uniprot
proteins
pubmed
20941364
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21800163
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
33963192
uniprot
proteins
sequence_length
824
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10601333, ECO:0000305|PubMed:12095920}. Nucleus, gem {ECO:0000269|PubMed:10601333, ECO:0000305|PubMed:10383418}. Note=Localized in subnuclear structures next to coiled bodies, called Gemini of Cajal bodies (Gems). {ECO:0000269|PubMed:10601333}.
uniprot
proteins