Inha
entrez
16322
canonical
uniprot
Q04997
canonical
ensembl
ENSMUSG00000032968
resolver
ensp
ENSMUSP00000040310
resolver
enst
ENSMUST00000037330
resolver
genesymbol
Inha
resolver
uniprot
Q6GTG7
resolver
uniprot_entry
INHA_MOUSE
resolver
uniprot_sec
Q6GTG7
resolver
amino_acid_sequence
MVSQRSLLLLLLLTLRDVDSCQGPELVRELVLAKVKALFLDALGPPAMDGEGGDPGIRRLPRRHAVGGFMHRTSEPEEEDVSQAILFPATGATCEDQPAARGLAQEAEEGLFTYVFRPSQHIRSHQVTSAQLWFHTGLGRKSTAAANSSAPLLDLLVLSSGGPMAVPVSLGQGPPRWAVLHLAASAFPLLTHPILVLLLRCPLCSCSGRPETTPFLVAHTRARAPSAGERARRSTPSVPWPWSPAALRLLQRPPEEPAAHAFCHRAALNISFQELGWDRWIVHPPSFIFHYCHGSCGMPTSDLPLPVPGVPPTPVQPLFLVPGAKPCCAALPGSMRSLRVRTTSDGGYSFKYEMVPNLITQHCACI
uniprot
proteins
function
FUNCTION: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. {ECO:0000269|PubMed:1448148, ECO:0000269|PubMed:8090730, ECO:0000269|PubMed:8701077}.; FUNCTION: Inhibin A is a dimer of alpha/INHA and beta-A/INHBA that functions as a feedback regulator in the hypothalamic-pituitary-gonadal (HPG) axis. Inhibits the secretion of FSH from the anterior pituitary gland by acting on pituitary gonadotrope cells. Antagonizes activin A by binding to the proteoglycan, betaglycan, and forming a stable complex with and, thereby, sequestering type II activin receptors while excluding type I receptor. {ECO:0000250|UniProtKB:P08476}.; FUNCTION: Inhibin B is a dimer of alpha and beta-B that plays a crucial role in the regulation of the reproductive system by inhibiting the secretion of follicle-stimulating hormone (FSH) from the anterior pituitary gland. Thereby, maintains reproductive homeostasis in both males and females. Acts as a more potent suppressor of FSH release than inhibin A (By similarity). Functions as competitive receptor antagonist binding activin type II receptors with high affinity in the presence of the TGF-beta type III coreceptor/TGFBR3L (By similarity). {ECO:0000250|UniProtKB:P05111, ECO:0000250|UniProtKB:P17490}.
uniprot
proteins
mass_dalton
39550
uniprot
proteins
post_translational_modification
PTM: Proteolytic processing yields a number of bioactive forms, consisting either solely of the mature alpha chain, of the most N-terminal propeptide linked through a disulfide bond to the mature alpha chain, or of the entire proprotein.
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
1448148
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1632772
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2253839
uniprot
proteins
pubmed
8090730
uniprot
proteins
pubmed
8330535
uniprot
proteins
pubmed
8701077
uniprot
proteins
sequence_length
366
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P17490}.
uniprot
proteins