Kmt2b
entrez
75410
canonical
uniprot
O08550
canonical
ensembl
ENSMUSG00000006307
resolver
ensp
ENSMUSP00000006470
resolver
ensp
ENSMUSP00000103789
resolver
ensp
ENSMUSP00000118486
resolver
enst
ENSMUST00000006470
resolver
enst
ENSMUST00000108154
resolver
genesymbol
Kmt2b
resolver
genesymbol_syn
Mll2
resolver
genesymbol_syn
Trx2
resolver
genesymbol_syn
Wbp7
resolver
uniprot
E9QKF4
resolver
uniprot
F8WJ40
resolver
uniprot
Q5NU09
resolver
uniprot
Q6PHU4
resolver
uniprot_entry
F8WJ40_MOUSE
resolver
uniprot_entry
KMT2B_MOUSE
resolver
uniprot_entry
Q6PHU4_MOUSE
resolver
uniprot_sec
E9QKF4
resolver
uniprot_sec
Q5NU09
resolver
amino_acid_sequence
MAAAAGGGSCPGPGSARGRFPGRPRGSGGGGGRGGRGNGAERVRVALRRGGGAAGPGGAEPGEDTALLRLLGLRRGLRRLRRLWAGARVQRGRGRGRGRGWGPNRGCMPEEESSDGESEEEEFQGFHSDEDVAPSSLRSALRSQRGRAPRGRGRKHKTTPLPPRLADVTPVPPKAPTRKRGEEGTERMVQALTELLRRSQAPQPPRSRARAREPSTPRRSRGRPPGRPAGPCRKKQQAVVLAEAAVTIPKPEPPPPVVPVKNKAGSWKCKEGPGPGPGTPKRGGQPGRGGRGGRGRGRGGLPLMIKFVSKAKKVKMGQLSQELESGQGHGQRGESWQDAPQRKDGDEPERGSCRKKQEQKLEEEEEEEEKEGEEKEEKDDNEDNNKQEEEEETERAVAEEEAMLAKEKEEAKLPSPPLTPPVPSPPPPLPPPSTSPPPPASPLPPPVSPPPPLSPPPYPAPEKQEESPPLVPATCSRKRGRPPLTPSQRAEREAARSGPEGTLSPTPNPSTTTGSPLEDSPTVVPKSTTFLKNIRQFIMPVVSARSSRVIKTPRRFMDEDPPKPPKVEASIVRPPVATSPPAPQEPVPVSSPPRVPTPPSTPVPLPEKRRSILREPTFRWTSLTRELPPPPPAPPPAPSPPPAPATPSRRPLLLRAPQFTPSEAHLKIYESVLTPPPLGALETPEPELPPADDSPAEPEPRAVGRTNHLSLPRFVPVVTSPVKVEVPPHGAPALSEGQQLQLQQPPQALQTQLLPQALPPQQPQAQPPPSPQHTPPLEKARVASLGSLPLSGVEEKMFSLLKRAKVQLFKIDQQQQQKVAASMPLSPAVQTEEAVGTVKQTPDRGCVRSEDESMEAKRDRASGPESPLQGPRIKHVCRHAAVALGQARAMVPEDVPRLSALPLRDRQDLATEDTSSASETESVPSRSQREKVESAGPGGDSEPTGSTGALAHTPRRSLPSHHGKKMRMARCGHCRGCLRVQDCGSCVNCLDKPKFGGPNTKKQCCVYRKCDKIEARKMERLAKKGRTIVKTLLPWDSDESPEASPGPPGPRRGAGAGGSREEVGATPGPEEQDSLLLQRKSARRCVKQRPSYDVFEDSDDSEPGGPPAPRRRTPREHELPVLEPEEQSRPRKPTLQPVLQLKARRRLDKDALAPGPFASFPNGWTGKQKSPDGVHRVRVDFKEDCDLENVWLMGGLSVLTSVPGGPPMVCLLCASKGLHELVFCQVCCDPFHPFCLEEAERPSPQHRDTWCCRRCKFCHVCGRKGRGSKHLLECERCRHAYHPACLGPSYPTRATRRRRHWICSACVRCKSCGATPGKNWDVEWSGDYSLCPRCTELYEKGNYCPICTRCYEDNDYESKMMQCAQCDHWVHAKCEGLSDEDYEILSGLPDSVLYTCGPCAGATQPRWREALSGALQGGLRQVLQGLLSSKVAGPLLLCTQCGQDGKQLHPGPCDLQAVGKRFEEGLYKSVHSFMEDVVAILMRHSEEGETPERRAGSQMKGLLLKLLESAFCWFDAHDPKYWRRSTRLPNGVLPNAVLPPSLDHVYAQWRQQESETPESGQPPGDPSAAFQSKDPAAFSHLDDPRQCALCLKYGDADSKEAGRLLYIGQNEWTHVNCAIWSAEVFEENDGSLKNVHAAVARGRQMRCELCLKPGATVGCCLSSCLSNFHFMCARASYCIFQDDKKVFCQKHTDLLDGKEIVTPDGFDVLRRVYVDFEGINFKRKFLTGLEPDVINVLIGSIRINSLGTLSDLSDCEGRLFPIGYQCSRLYWSTVDARRRCWYRCRILEYRPWGPREEPVHLEAAEENQTIVHSPTPSSDTDSLIPGDPVHHSPIQNLDPPLRTDSSNGPPPTPRSFSGARIKVPNYSPSRRPLGGVSFGPLPSPGSPSSLTHHIPTVGDSDFPAPPRRSRRPSPLATRPPPSRRTSSPLRTSPQLRVPLSTSVTALTPTSGELAPPDLAPSPLPPSEDLGPDFEDMEVVSGLSAADLDFAASLLGTEPFQEEIVAAGAVGSSQGGPGDSSEEEASPTTHYVHFPVTVVSGPALAPSSLAGAPRIEQLDGVDDGTDSEAEAVQQPRGQGTPPSGPGVGRGGVLGAAGDRAQPPEDLPSEIVDFVLKNLGGPGEGAAGPREDSLPSAPPLANGSQPPQSLSTSPADPTRTFAWLPGAPGVRVLSLGPAPEPPKPATSKIILVNKLGQVFVKMAGEGEPVAPPVKQPPLPPIIPPTAPTSWTLPPGPLLSVLPVVGVGVVRPAPPPPPPPLTLVFSSGPPSPPRQAIRVKRVSTFSGRSPPVPPPNKTPRLDEDGESLEDAHHVPGISGSGFSRVRMKTPTVRGVLDLNNPGEQPEEESPGRPQDRCPLLPLAEAPSQALDGSSDLLFESQWHHYSAGEASSSEEEPPSPEDKENQVPKRVGPHLRFEISSDDGFSVEAESLEVAWRTLIEKVQEARGHARLRHLSFSGMSGARLLGIHHDAVIFLAEQLPGAQRCQHYKFRYHQQGEGQEEPPLNPHGAARAEVYLRKCTFDMFNFLASQHRVLPEGATCDEEEDEVQLRSTRRATSLELPMAMRFRHLKKTSKEAVGVYRSAIHGRGLFCKRNIDAGEMVIEYSGIVIRSVLTDKREKFYDGKGIGCYMFRMDDFDVVDATMHGNAARFINHSCEPNCFSRVIHVEGQKHIVIFALRRILRGEELTYDYKFPIEDASNKLPCNCGAKRCRRFLN
uniprot
proteins
ec_number
2.1.1.364
uniprot
proteins
function
FUNCTION: Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (By similarity). Likely plays a redundant role with KMT2C in enriching H3K4me1 marks on primed and active enhancer elements (By similarity). Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2 (By similarity). Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development (PubMed:20808952). Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation (PubMed:20808952). {ECO:0000250|UniProtKB:Q9UMN6, ECO:0000269|PubMed:20808952}.
uniprot
proteins
mass_dalton
294821
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
Histone-lysine methyltransferase family
uniprot
proteins
protein_family
TRX/MLL subfamily
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20808952
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9171351
uniprot
proteins
sequence_length
2713
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UMN6}.
uniprot
proteins