Slu7
entrez
193116
canonical
uniprot
Q8BHJ9
canonical
ensembl
ENSMUSG00000020409
resolver
ensp
ENSMUSP00000020681
resolver
ensp
ENSMUSP00000137281
resolver
ensp
ENSMUSP00000291007
resolver
ensp
ENSMUSP00000291011
resolver
enst
ENSMUST00000020681
resolver
enst
ENSMUST00000178622
resolver
genesymbol
Slu7
resolver
genesymbol_syn
D11Ertd730e
resolver
uniprot
Q3KQQ3
resolver
uniprot
Q5SRU1
resolver
uniprot
Q63ZX3
resolver
uniprot
Q6P923
resolver
uniprot
Q8BL59
resolver
uniprot
Q8BXD5
resolver
uniprot
Q8R5C1
resolver
uniprot
Q91YV6
resolver
uniprot_entry
SLU7_MOUSE
resolver
uniprot_sec
Q3KQQ3
resolver
uniprot_sec
Q5SRU1
resolver
uniprot_sec
Q63ZX3
resolver
uniprot_sec
Q6P923
resolver
uniprot_sec
Q8BL59
resolver
uniprot_sec
Q8BXD5
resolver
uniprot_sec
Q8R5C1
resolver
uniprot_sec
Q91YV6
resolver
amino_acid_sequence
MSAAAVDPVSATPMTGSKEMSLEEPKKMTREDWRKKKELEEQRKLGNAPAEVDEEGKDINPHIPQYISSVPWYIDPSKRPTLKHQRPQPEKQKQFSSSGEWYKRGVKENSITTKYRKGACENCGAMTHKRKDCFERPRRVGAKFTGTNIAPDEHVQPQLMFDYDGKRDRWNGYNPEEHMKIVEEYAKVDLAKRTLKAQKLQEELASGKLVEQANSPKHQWGEEEPNSQMEKDHNSEDEDEDKYADDIDMPGQNFDSKRRITVRNLRIREDIAKYLRNLDPNSAYYDPKTRAMRENPYANAGKNPDEVSYAGDNFVRYTGDTISMAQTQLFAWEAYDKGSEVHLQADPTKLELLYKSFKVKKEDFKEQQKESILEKYGGQEHLDAPPAELLLAQTEDYVEYSRHGTVIKGQERAVACSKYEEDVKINNHTHIWGSYWKEGRWGYKCCHSFFKYSYCTGEAGKESVNSEECIITGATAEESVKKPQALLELHQEKLKEEKKKKKKKKKHRKSSSDSDDEERKQEKLKKALNAEEARLLHVKEIMQIDERKRPYNSIYETREPTEEEMEAYRMKRQRPDDPMASFLGQ
uniprot
proteins
function
FUNCTION: Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. {ECO:0000250|UniProtKB:O95391}.
uniprot
proteins
mass_dalton
68080
uniprot
proteins
protein_family
SLU7 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
585
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O95391}. Nucleus speckle {ECO:0000250|UniProtKB:O95391}. Cytoplasm {ECO:0000250|UniProtKB:O95391}. Note=Predominantly nuclear. Shuttling between the nucleus and the cytoplasm is regulated by the CCHC-type zinc finger. Upon UV-C stress stimulus, the nuclear concentration of the protein decreases, affecting alternative splicing. Translocates from the nucleus to the cytoplasm after heat shock cell treatment. Accumulates in cytoplasmic vesicle-like organelles after heat shock treatment, which may represent stress granules. {ECO:0000250|UniProtKB:O95391}.
uniprot
proteins