BRI3
entrez
25798
canonical
uniprot
O95415
canonical
ensembl
ENSG00000164713
resolver
ensp
ENSP00000297290
resolver
ensp
ENSP00000440936
resolver
ensp
ENSP00000655205
resolver
ensp
ENSP00000709439
resolver
genesymbol
BRI3
resolver
hgnc
HGNC:1109
resolver
uniprot
D6W5R8
resolver
uniprot
F5GXW6
resolver
uniprot
Q8WV52
resolver
uniprot
Q9UIC6
resolver
uniprot_entry
BRI3_HUMAN
resolver
uniprot_sec
D6W5R8
resolver
uniprot_sec
F5GXW6
resolver
uniprot_sec
Q8WV52
resolver
uniprot_sec
Q9UIC6
resolver
amino_acid_sequence
MDHKPLLQERPPAYNLEAGQGDYACGPHGYGAIPAAPPPPPYPYLVTGIPTHHPRVYNIHSRTVTRYPANSIVVVGGCPVCRVGVLEDCFTFLGIFLAIILFPFGFICCFALRKRRCPNCGATFA
uniprot
proteins
function
FUNCTION: Participates in tumor necrosis factor-alpha (TNF)-induced cell death (PubMed:14592447). May be a target of Wnt/beta-catenin signaling in the liver (PubMed:20538055). {ECO:0000269|PubMed:14592447, ECO:0000269|PubMed:20538055}.
uniprot
proteins
mass_dalton
13645
uniprot
proteins
protein_family
BRI3 family
uniprot
proteins
pubmed
11860200
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14592447
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20538055
uniprot
proteins
pubmed
30983867
uniprot
proteins
sequence_length
125
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000305|PubMed:14592447}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:30983867}. Note=Co-localizes with MGAT1 and IFITM3 at the perinuclear region. {ECO:0000269|PubMed:30983867}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:30983867}. Nucleus {ECO:0000269|PubMed:30983867}. Note=Diffuse localization in the cytoplasm and nucleus. {ECO:0000269|PubMed:30983867}.
uniprot
proteins
transmembrane_region
TRANSMEM 67..86; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 92..112; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins