Sema7a
entrez
20361
canonical
uniprot
Q9QUR8
canonical
ensembl
ENSMUSG00000038264
resolver
ensp
ENSMUSP00000042211
resolver
enst
ENSMUST00000043059
resolver
genesymbol
Sema7a
resolver
genesymbol_syn
Cd108
resolver
genesymbol_syn
Semal
resolver
genesymbol_syn
Semk1
resolver
uniprot
O88371
resolver
uniprot_entry
SEM7A_MOUSE
resolver
uniprot_sec
O88371
resolver
amino_acid_sequence
MTPPPPGRAAPSAPRARVLSLPARFGLPLRLRLLLVFWVAAASAQGHSRSGPRISAVWKGQDHVDFSQPEPHTVLFHEPGSFSVWVGGRGKVYHFNFPEGKNASVRTVNIGSTKGSCQDKQDCGNYITLLERRGNGLLVCGTNARKPSCWNLVNDSVVMSLGEMKGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQNPQFIKATIVHQDQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSVSKWNTFLKAMLVCSDAATNRNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNYSAVCVYSLGDIDRVFRTSSLKGYHMGLPNPRPGMCLPKKQPIPTETFQVADSHPEVAQRVEPMGPLKTPLFHSKYHYQKVVVHRMQASNGETFHVLYLTTDRGTIHKVVESGDQDHSFVFNIMEIQPFHRAAAIQAISLDADRRKLYVTSQWEVSQVPLDMCEVYSGGCHGCLMSRDPYCGWDQDRCVSIYSSQRSVLQSINPAEPHRECPNPKPDEAPLQKVSLARNSRYYLTCPMESRHATYLWRHEENVEQSCEPGHQSPSCILFIENLTARQYGHYRCEAQEGSYLREAQHWELLPEDRALAEQLMGHARALAASFWLGVLPTLILGLLVH
uniprot
proteins
function
FUNCTION: Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of pro-inflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes. {ECO:0000269|PubMed:12879062, ECO:0000269|PubMed:16713976, ECO:0000269|PubMed:17377534}.
uniprot
proteins
mass_dalton
74994
uniprot
proteins
mutagenesis
MUTAGEN 145; /note="R->W: Homozygous mutant mice show signs of hepatocytes degeneration associated with elevated serum levels of total bile acid, alanine transaminase and aspartate transaminase. Levels of the canalicular bile acid transporters ABCB11 and ABCC2 are reduced."; /evidence="ECO:0000269|PubMed:34585848
uniprot
proteins
protein_family
Semaphorin family
uniprot
proteins
pubmed
10885563
uniprot
proteins
pubmed
12879062
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16713976
uniprot
proteins
pubmed
17377534
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
34585848
uniprot
proteins
pubmed
9721204
uniprot
proteins
pubmed
9878861
uniprot
proteins
sequence_length
664
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17377534}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17377534}; Extracellular side {ECO:0000269|PubMed:17377534}.
uniprot
proteins