Epcam
entrez
171577
canonical
uniprot
O55159
canonical
ensembl
ENSRNOG00000015667
resolver
ensembl
ENSRNOG00055018673
resolver
ensembl
ENSRNOG00060003884
resolver
ensembl
ENSRNOG00065007838
resolver
ensp
ENSRNOP00000021135
resolver
ensp
ENSRNOP00055025734
resolver
ensp
ENSRNOP00060004855
resolver
ensp
ENSRNOP00065008993
resolver
enst
ENSRNOT00000021135
resolver
enst
ENSRNOT00055031829
resolver
enst
ENSRNOT00060006487
resolver
enst
ENSRNOT00065012293
resolver
genesymbol
Epcam
resolver
genesymbol_syn
Tacstd1
resolver
uniprot_entry
EPCAM_RAT
resolver
amino_acid_sequence
MAPPKALAFGLLLAVVTATLAAAQKDCVCNNYKLTSRCYENENGECQCTSYGTQNTVICSKLASKCLVMKAEMTHSKSGRRMKPEGAIQNNDGLYDPECDEQGLFKAKQCNGTATCWCVNTAGVRRTDKDTEITCSERVRTYWIIIELKHKERAQPYNFESLHTALQDTFASRYMLNPKFIKSIMYENNVITIDLMQNSSQKTQDDVDIADVAYYFEKDVKGESLFHSSKSMDLRVNGELLDLDPGQTLIYYVDEKAPEFSMQGLTAGIIAVIVVVVLAVIAGIVVLVISTRKRSAKYEKAEIKEMGEIHRELNA
uniprot
proteins
function
FUNCTION: May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
35207
uniprot
proteins
post_translational_modification
PTM: Glycosylation at Asn-198 is crucial for protein stability. {ECO:0000250}.
uniprot
proteins
protein_family
EPCAM family
uniprot
proteins
pubmed
10327052
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16054130
uniprot
proteins
sequence_length
315
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lateral cell membrane {ECO:0000269|PubMed:16054130}; Single-pass type I membrane protein {ECO:0000269|PubMed:16054130}. Cell junction, tight junction {ECO:0000269|PubMed:16054130}. Note=Colocalizes with CLDN7 at the lateral cell membrane and tight junction. {ECO:0000269|PubMed:16054130}.
uniprot
proteins
transmembrane_region
TRANSMEM 267..289; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins