GOLGA5
entrez
9950
canonical
uniprot
Q8TBA6
canonical
ensembl
ENSG00000066455
resolver
ensp
ENSP00000163416
resolver
ensp
ENSP00000538435
resolver
ensp
ENSP00000738137
resolver
genesymbol
GOLGA5
resolver
genesymbol_syn
RETII
resolver
genesymbol_syn
RFG5
resolver
hgnc
HGNC:4428
resolver
uniprot
C9JRU1
resolver
uniprot
O95287
resolver
uniprot
Q03962
resolver
uniprot
Q2TS49
resolver
uniprot
Q9UQQ7
resolver
uniprot_entry
GOGA5_HUMAN
resolver
uniprot_sec
C9JRU1
resolver
uniprot_sec
O95287
resolver
uniprot_sec
Q03962
resolver
uniprot_sec
Q2TS49
resolver
uniprot_sec
Q9UQQ7
resolver
amino_acid_sequence
MSWFVDLAGKAEDLLNRVDQGAATALSRKDNASNIYSKNTDYTELHQQNTDLIYQTGPKSTYISSAADNIRNQKATILAGTANVKVGSRTPVEASHPVENASVPRPSSHFVRRKKSEPDDELLFDFLNSSQKEPTGRVEIRKEKGKTPVFQSSQTSSVSSVNPSVTTIKTIEENSFGSQTHEAASNSDSSHEGQEESSKENVSSNAACPDHTPTPNDDGKSHELSNLRLENQLLRNEVQSLNQEMASLLQRSKETQEELNKARARVEKWNADHSKSDRMTRGLRAQVDDLTEAVAAKDSQLAVLKVRLQEADQLLSTRTEALEALQSEKSRIMQDQSEGNSLQNQALQTFQERLHEADATLKREQESYKQMQSEFAARLNKVEMERQNLAEAITLAERKYSDEKKRVDELQQQVKLYKLNLESSKQELIDYKQKATRILQSKEKLINSLKEGSGFEGLDSSTASSMELEELRHEKEMQREEIQKLMGQIHQLRSELQDMEAQQVNEAESAREQLQDLHDQIAGQKASKQELETELERLKQEFHYIEEDLYRTKNTLQSRIKDRDEEIQKLRNQLTNKTLSNSSQSELENRLHQLTETLIQKQTMLESLSTEKNSLVFQLERLEQQMNSASGSSSNGSSINMSGIDNGEGTRLRNVPVLFNDTETNLAGMYGKVRKAASSIDQFSIRLGIFLRRYPIARVFVIIYMALLHLWVMIVLLTYTPEMHHDQPYGK
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving GOLGA5 is found in papillary thyroid carcinomas (PTCs). Translocation t(10;14)(q11;q32) with RET. The translocation generates the RET/GOLGA5 (PTC5) oncogene. {ECO:0000269|PubMed:2734021, ECO:0000269|PubMed:9443391}.
uniprot
proteins
function
FUNCTION: Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport. {ECO:0000269|PubMed:12538640, ECO:0000269|PubMed:15718469}.
uniprot
proteins
mass_dalton
83024
uniprot
proteins
post_translational_modification
PTM: Highly phosphorylated during mitosis. Phosphorylation is barely detectable during interphase. {ECO:0000269|PubMed:12538640}.
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
12538640
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15718469
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2734021
uniprot
proteins
pubmed
9443391
uniprot
proteins
pubmed
9915833
uniprot
proteins
sequence_length
731
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:9915833}; Single-pass type IV membrane protein {ECO:0000269|PubMed:9915833}. Note=Found throughout the Golgi, both on cisternae and, at higher abundance, on the tubulo-vesicular structures of the cis-Golgi network.
uniprot
proteins
transmembrane_region
TRANSMEM 699..719; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins