Mfge8
entrez
17304
canonical
uniprot
P21956
canonical
ensembl
ENSMUSG00000030605
resolver
ensp
ENSMUSP00000032825
resolver
ensp
ENSMUSP00000103032
resolver
genesymbol
Mfge8
resolver
uniprot
P97800
resolver
uniprot
Q3TBN5
resolver
uniprot
Q3TDU5
resolver
uniprot
Q3U8S9
resolver
uniprot
Q9R1X9
resolver
uniprot
Q9WTS3
resolver
uniprot_entry
MFGM_MOUSE
resolver
uniprot_entry
Q3TDU5_MOUSE
resolver
uniprot_sec
P97800
resolver
uniprot_sec
Q3TBN5
resolver
uniprot_sec
Q3U8S9
resolver
uniprot_sec
Q9R1X9
resolver
uniprot_sec
Q9WTS3
resolver
amino_acid_sequence
MQVSRVLAALCGMLLCASGLFAASGDFCDSSLCLNGGTCLTGQDNDIYCLCPEGFTGLVCNETERGPCSPNPCYNDAKCLVTLDTQRGDIFTEYICQCPVGYSGIHCETETNYYNLDGEYMFTTAVPNTAVPTPAPTPDLSNNLASRCSTQLGMEGGAIADSQISASSVYMGFMGLQRWGPELARLYRTGIVNAWTASNYDSKPWIQVNLLRKMRVSGVMTQGASRAGRAEYLKTFKVAYSLDGRKFEFIQDESGGDKEFLGNLDNNSLKVNMFNPTLEAQYIKLYPVSCHRGCTLRFELLGCELHGCSEPLGLKNNTIPDSQMSASSSYKTWNLRAFGWYPHLGRLDNQGKINAWTAQSNSAKEWLQVDLGTQRQVTGIITQGARDFGHIQYVASYKVAHSDDGVQWTVYEEQGSSKVFQGNLDNNSHKKNIFEKPFMARYVRVLPVSWHNRITLRLELLGC
uniprot
proteins
function
FUNCTION: Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction (By similarity). Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization. {ECO:0000250, ECO:0000269|PubMed:15834428, ECO:0000269|PubMed:18008006}.
uniprot
proteins
mass_dalton
51241
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. Isoform 1 also exists in both an O-glycosylated and a non-O-glycosylated form. {ECO:0000269|PubMed:9920772}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15834428
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18008006
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2122462
uniprot
proteins
pubmed
23262193
uniprot
proteins
pubmed
9546740
uniprot
proteins
pubmed
9920772
uniprot
proteins
sequence_length
463
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:2122462}; Peripheral membrane protein {ECO:0000269|PubMed:2122462}. Secreted {ECO:0000269|PubMed:2122462}. Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:P79385}; Peripheral membrane protein {ECO:0000250|UniProtKB:P79385}. Note=Located in the acrosomal region of zona-pellucida bound sperm. {ECO:0000250|UniProtKB:P79385}.
uniprot
proteins