Cby1
entrez
73739
canonical
uniprot
Q9D1C2
canonical
ensembl
ENSMUSG00000022428
resolver
ensp
ENSMUSP00000023064
resolver
enst
ENSMUST00000023064
resolver
genesymbol
Cby1
resolver
genesymbol_syn
Cby
resolver
genesymbol_syn
Pgea1
resolver
uniprot_entry
CBY1_MOUSE
resolver
amino_acid_sequence
MPLFGSIFSPKKTPPRKSASLSNLHSLDRSTRELELGLDYGTPTMNLAGQSLKFENGQWVADSVISGGVDRRETQRLRKRNQQLEEENNLLRLKVDILLDMLSETTAESHLKDKELDELKVTNRRRK
uniprot
proteins
function
FUNCTION: Inhibits the Wnt/Wingless pathway by binding to CTNNB1/beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors (By similarity). Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins (By similarity). Promotes adipocyte and cardiomyocyte differentiation (PubMed:17261658, PubMed:17403895). {ECO:0000250|UniProtKB:Q9Y3M2, ECO:0000269|PubMed:17261658, ECO:0000269|PubMed:17403895}.
uniprot
proteins
mass_dalton
14535
uniprot
proteins
protein_family
Chibby family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17261658
uniprot
proteins
pubmed
17403895
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
38197861
uniprot
proteins
sequence_length
127
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q9Y3M2}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9Y3M2}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q9Y3M2}. Golgi apparatus {ECO:0000250|UniProtKB:Q9Y3M2}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q9Y3M2}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:38197861}. Nucleus {ECO:0000250|UniProtKB:Q9Y3M2}. Cytoplasm {ECO:0000250|UniProtKB:Q9Y3M2}.
uniprot
proteins