CAPRIN2
entrez
65981
canonical
uniprot
Q6IMN6
canonical
ensembl
ENSG00000110888
resolver
ensp
ENSP00000298892
resolver
ensp
ENSP00000379150
resolver
ensp
ENSP00000391479
resolver
ensp
ENSP00000415407
resolver
ensp
ENSP00000438010
resolver
ensp
ENSP00000441005
resolver
ensp
ENSP00000442295
resolver
ensp
ENSP00000443353
resolver
ensp
ENSP00000509126
resolver
ensp
ENSP00000510009
resolver
ensp
ENSP00000510181
resolver
ensp
ENSP00000510623
resolver
ensp
ENSP00000510778
resolver
ensp
ENSP00000511807
resolver
ensp
ENSP00000511809
resolver
ensp
ENSP00000511811
resolver
ensp
ENSP00000511846
resolver
ensp
ENSP00000511879
resolver
ensp
ENSP00000511883
resolver
ensp
ENSP00000563401
resolver
ensp
ENSP00000563402
resolver
ensp
ENSP00000563403
resolver
ensp
ENSP00000563404
resolver
ensp
ENSP00000563405
resolver
ensp
ENSP00000563406
resolver
ensp
ENSP00000563407
resolver
ensp
ENSP00000563408
resolver
ensp
ENSP00000563410
resolver
ensp
ENSP00000563411
resolver
ensp
ENSP00000563412
resolver
ensp
ENSP00000591433
resolver
ensp
ENSP00000591437
resolver
ensp
ENSP00000591439
resolver
ensp
ENSP00000591442
resolver
ensp
ENSP00000591443
resolver
ensp
ENSP00000624267
resolver
ensp
ENSP00000624268
resolver
ensp
ENSP00000624269
resolver
ensp
ENSP00000624271
resolver
ensp
ENSP00000624272
resolver
ensp
ENSP00000624273
resolver
ensp
ENSP00000624274
resolver
ensp
ENSP00000624275
resolver
ensp
ENSP00000624276
resolver
ensp
ENSP00000624282
resolver
ensp
ENSP00000624283
resolver
ensp
ENSP00000655815
resolver
ensp
ENSP00000712136
resolver
ensp
ENSP00000712138
resolver
ensp
ENSP00000712139
resolver
ensp
ENSP00000712145
resolver
ensp
ENSP00000712149
resolver
ensp
ENSP00000740841
resolver
ensp
ENSP00000740844
resolver
enst
ENST00000540436
resolver
enst
ENST00000540584
resolver
enst
ENST00000542550
resolver
enst
ENST00000686317
resolver
enst
ENST00000690126
resolver
enst
ENST00000692932
resolver
enst
ENST00000695326
resolver
enst
ENST00000695330
resolver
enst
ENST00000695400
resolver
enst
ENST00000695402
resolver
enst
ENST00000893342
resolver
enst
ENST00000893343
resolver
enst
ENST00000893344
resolver
enst
ENST00000893345
resolver
enst
ENST00000893349
resolver
enst
ENST00000893351
resolver
enst
ENST00000893352
resolver
enst
ENST00000893353
resolver
enst
ENST00000921378
resolver
enst
ENST00000954209
resolver
enst
ENST00000954212
resolver
enst
ENST00000954215
resolver
enst
ENST00000954223
resolver
enst
ENST00000954224
resolver
genesymbol
CAPRIN2
resolver
genesymbol_syn
C1QDC1
resolver
genesymbol_syn
EEG1
resolver
genesymbol_syn
KIAA1873
resolver
genesymbol_syn
RNG140
resolver
hgnc
HGNC:21259
resolver
uniprot
A0A8I5KRN0
resolver
uniprot
A0A8I5KSM9
resolver
uniprot
A0A8I5KZC0
resolver
uniprot
A0A8Q3SHS5
resolver
uniprot
A0A8Q3WKC4
resolver
uniprot
E4NKG2
resolver
uniprot
F5GXI7
resolver
uniprot
F5H5J8
resolver
uniprot
F5H7T6
resolver
uniprot
Q149P6
resolver
uniprot
Q149P7
resolver
uniprot
Q6IMN5
resolver
uniprot
Q7Z371
resolver
uniprot
Q8TE70
resolver
uniprot
Q8TE71
resolver
uniprot
Q96RN6
resolver
uniprot
Q9H667
resolver
uniprot
Q9HAL4
resolver
uniprot_entry
A0A8I5KRN0_HUMAN
resolver
uniprot_entry
A0A8I5KSM9_HUMAN
resolver
uniprot_entry
A0A8I5KZC0_HUMAN
resolver
uniprot_entry
A0A8Q3SHS5_HUMAN
resolver
uniprot_entry
A0A8Q3WKC4_HUMAN
resolver
uniprot_entry
CAPR2_HUMAN
resolver
uniprot_entry
F5GXI7_HUMAN
resolver
uniprot_entry
F5H5J8_HUMAN
resolver
uniprot_sec
E4NKG2
resolver
uniprot_sec
F5H7T6
resolver
uniprot_sec
Q149P6
resolver
uniprot_sec
Q149P7
resolver
uniprot_sec
Q6IMN5
resolver
uniprot_sec
Q7Z371
resolver
uniprot_sec
Q8TE70
resolver
uniprot_sec
Q8TE71
resolver
uniprot_sec
Q96RN6
resolver
uniprot_sec
Q9H667
resolver
uniprot_sec
Q9HAL4
resolver
amino_acid_sequence
MEVQVSQASLGFELTSVEKSLREWSRLSREVIAWLCPSSPNFILNFPPPPSASSVSMVQLFSSPFGYQSPSGHSEEEREGNMKSAKPQVNHSQHGESQRALSPLQSTLSSAASPSQAYETYIENGLICLKHKIRNIEKKKLKLEDYKDRLKSGEHLNPDQLEAVEKYEEVLHNLEFAKELQKTFSGLSLDLLKAQKKAQRREHMLKLEAEKKKLRTILQVQYVLQNLTQEHVQKDFKGGLNGAVYLPSKELDYLIKFSKLTCPERNESLSVEDQMEQSSLYFWDLLEGSEKAVVGTTYKHLKDLLSKLLNSGYFESIPVPKNAKEKEVPLEEEMLIQSEKKTQLSKTESVKESESLMEFAQPEIQPQEFLNRRYMTEVDYSNKQGEEQPWEADYARKPNLPKRWDMLTEPDGQEKKQESFKSWEASGKHQEVSKPAVSLEQRKQDTSKLRSTLPEEQKKQEISKSKPSPSQWKQDTPKSKAGYVQEEQKKQETPKLWPVQLQKEQDPKKQTPKSWTPSMQSEQNTTKSWTTPMCEEQDSKQPETPKSWENNVESQKHSLTSQSQISPKSWGVATASLIPNDQLLPRKLNTEPKDVPKPVHQPVGSSSTLPKDPVLRKEKLQDLMTQIQGTCNFMQESVLDFDKPSSAIPTSQPPSATPGSPVASKEQNLSSQSDFLQEPLQATSSPVTCSSNACLVTTDQASSGSETEFMTSETPEAAIPPGKQPSSLASPNPPMAKGSEQGFQSPPASSSSVTINTAPFQAMQTVFNVNAPLPPRKEQEIKESPYSPGYNQSFTTASTQTPPQCQLPSIHVEQTVHSQETAANYHPDGTIQVSNGSLAFYPAQTNVFPRPTQPFVNSRGSVRGCTRGGRLITNSYRSPGGYKGFDTYRGLPSISNGNYSQLQFQAREYSGAPYSQRDNFQQCYKRGGTSGGPRANSRAGWSDSSQVSSPERDNETFNSGDSGQGDSRSMTPVDVPVTNPAATILPVHVYPLPQQMRVAFSAARTSNLAPGTLDQPIVFDLLLNNLGETFDLQLGRFNCPVNGTYVFIFHMLKLAVNVPLYVNLMKNEEVLVSAYANDGAPDHETASNHAILQLFQGDQIWLRLHRGAIYGSSWKYSTFSGYLLYQD
uniprot
proteins
function
FUNCTION: Promotes phosphorylation of the Wnt coreceptor LRP6, leading to increased activity of the canonical Wnt signaling pathway (PubMed:18762581). Facilitates constitutive LRP6 phosphorylation by CDK14/CCNY during G2/M stage of the cell cycle, which may potentiate cells for Wnt signaling (PubMed:27821587). May regulate the transport and translation of mRNAs, modulating for instance the expression of proteins involved in synaptic plasticity in neurons (By similarity). Involved in regulation of growth as erythroblasts shift from a highly proliferative state towards their terminal phase of differentiation (PubMed:14593112). May be involved in apoptosis (PubMed:14593112). {ECO:0000250|UniProtKB:Q05A80, ECO:0000269|PubMed:14593112, ECO:0000269|PubMed:18762581, ECO:0000269|PubMed:27821587}.
uniprot
proteins
mass_dalton
125925
uniprot
proteins
mutagenesis
MUTAGEN 1048; /note="I->R: Impaired homotrimer formation. No effect on LRP6 binding although LRP6 phosphorylation is significantly reduced."; /evidence="ECO:0000269|PubMed:25331957"; MUTAGEN 1078; /note="D->A: Loss of calcium binding and increased homotrimer stability; when associated with Ala-1084."; /evidence="ECO:0000269|PubMed:25331957"; MUTAGEN 1084; /note="E->A: Loss of calcium binding and increased homotrimer stability; when associated with Ala-1078."; /evidence="ECO:0000269|PubMed:25331957"; MUTAGEN 1091; /note="I->S: Impaired homotrimer formation. No effect on LRP6 binding although LRP6 phosphorylation is significantly reduced."; /evidence="ECO:0000269|PubMed:25331957"; MUTAGEN 1114; /note="W->S: No effect on homotrimer formation."; /evidence="ECO:0000269|PubMed:25331957"; MUTAGEN 1122; /note="Y->S: No effect on homotrimer formation."; /evidence="ECO:0000269|PubMed:25331957
uniprot
proteins
protein_family
Caprin family
uniprot
proteins
pubmed
14593112
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14764709
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18762581
uniprot
proteins
pubmed
20516077
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25331957
uniprot
proteins
pubmed
27821587
uniprot
proteins
sequence_length
1127
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion. Cytoplasm. Note=Expressed throughout the cytoplasm.; SUBCELLULAR LOCATION: [Isoform 5]: Mitochondrion. Note=Colocalizes with aggregated mitochondria.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:27821587}; Peripheral membrane protein {ECO:0000305}.
uniprot
proteins