Aqp7
entrez
29171
canonical
uniprot
P56403
canonical
genesymbol
Aqp7
resolver
uniprot
Q8K3F5
resolver
uniprot_entry
AQP7_RAT
resolver
uniprot_sec
Q8K3F5
resolver
activity_regulation
ACTIVITY REGULATION: Glycerol transport is regulated by pH, with the porin being permeable to glycerol at pH 7.4 but not at pH 5.5. Water permeability, however, is not influenced by pH (By similarity). Not inhibited by mercury ions. {ECO:0000250|UniProtKB:O14520, ECO:0000269|PubMed:9252401}.
uniprot
proteins
amino_acid_sequence
MAGSVLENIQSVLQKTWVREFLAEFLSTYVLMVFGLGSVAHMVLGERLGSYLGVNLGFGFGVTMGIHVAGGISGAHMNAAVTFTNCALGRMAWKKFPIYVLGQFLGSFLAAATTYLIFYGAINHYAGGELLVTGPKSTANIFATYLPEHMTLWRGFVDEVFVTGMLQLCIFAITDKLNSPALQGTEPLMIGILVCVLGVSLGMNTGYAINPSRDLPPRFFTFIAGWGKKVFSAGNNWWWVPVVAPLLGAYLGGIVYLGLIHAGIPPQGS
uniprot
proteins
function
FUNCTION: Aquaglyceroporins form homotetrameric transmembrane channels, with each monomer independently mediating glycerol and water transport across the plasma membrane along their osmotic gradient. Could also be permeable to urea (PubMed:9252401). Mediates the efflux of glycerol, formed upon triglyceride hydrolysis, to avoid its accumulation in adipocytes and to make it available to other tissues. In the kidney, mediates the reabsorption of glycerol, preventing its loss in urine, again participating to energy homeostasis. In pancreatic beta cells, it also mediates the efflux of glycerol, regulating its intracellular levels (By similarity). {ECO:0000250|UniProtKB:O54794, ECO:0000269|PubMed:9252401}.
uniprot
proteins
mass_dalton
28882
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by PKA could prevent the interaction with PLIN1. {ECO:0000250|UniProtKB:O14520}.
uniprot
proteins
protein_family
MIP/aquaporin (TC 1.A.8) family
uniprot
proteins
pubmed
12192003
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9252401
uniprot
proteins
sequence_length
269
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9252401}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55087}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:O54794}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55087}. Lipid droplet {ECO:0000250|UniProtKB:O54794}. Note=Internalized from the cell membrane in response to catecholamine-induced activation of PKA; detected on intracellular membranes and colocalizes with lipid droplets (By similarity). Colocalizes with PLIN1 in adipocytes, probably on lipid droplets (By similarity). {ECO:0000250|UniProtKB:O14520, ECO:0000250|UniProtKB:O54794}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..38; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:O14520"; TRANSMEM 52..69; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:O14520"; TRANSMEM 96..116; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:O14520"; TRANSMEM 152..172; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:O14520"; TRANSMEM 185..201; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:O14520"; TRANSMEM 238..259; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:O14520
uniprot
proteins