Gucy1b1
entrez
25202
canonical
uniprot
P20595
canonical
ensembl
ENSRNOG00000012060
resolver
ensembl
ENSRNOG00055001317
resolver
ensembl
ENSRNOG00060007224
resolver
ensembl
ENSRNOG00065030848
resolver
ensp
ENSRNOP00000062785
resolver
ensp
ENSRNOP00055001697
resolver
ensp
ENSRNOP00060008943
resolver
ensp
ENSRNOP00065043679
resolver
enst
ENSRNOT00000064930
resolver
enst
ENSRNOT00055002177
resolver
enst
ENSRNOT00060011888
resolver
enst
ENSRNOT00065053182
resolver
genesymbol
Gucy1b1
resolver
genesymbol_syn
Guc1b3
resolver
genesymbol_syn
Gucy1b3
resolver
uniprot
Q8CH88
resolver
uniprot_entry
GCYB1_RAT
resolver
uniprot_sec
Q8CH88
resolver
activity_regulation
ACTIVITY REGULATION: Activated by nitric oxide in the presence of magnesium or manganese ions. NO binding to the haem of the beta subunit GUCY1B1 induces a conformational change that allosterically activates the catalytic domain. {ECO:0000250|UniProtKB:Q02153}.
uniprot
proteins
amino_acid_sequence
MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLNLNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSFRCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRSEECDHTQFLIEEKESKEEDFYEDLDRFEENGTQDSRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVLPQLQPGKCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGAEISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQVWFLSRKNTGTEETNQDEN
uniprot
proteins
ec_number
4.6.1.2
uniprot
proteins
function
FUNCTION: Beta subunit of soluble guanylate cyclase (sGC), a key enzyme in nitric oxide (NO) signaling. sGC functions as a heterodimer consisting of one alpha and one beta subunit. It serves as the primary intracellular receptor for NO, which binds to a heme prosthetic group located on the beta subunit. Upon NO binding, sGC catalyzes the conversion of GTP into cyclic GMP (cGMP), thereby transmitting the NO signal into an ubiquitous intracellular second messenger. {ECO:0000250|UniProtKB:Q02153}.
uniprot
proteins
mass_dalton
70456
uniprot
proteins
protein_family
Adenylyl cyclase class-4/guanylyl cyclase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20105301
uniprot
proteins
pubmed
2905128
uniprot
proteins
sequence_length
619
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P16068}.
uniprot
proteins