Fdft1
entrez
14137
canonical
uniprot
P53798
canonical
ensembl
ENSMUSG00000021273
resolver
ensp
ENSMUSP00000055313
resolver
ensp
ENSMUSP00000153671
resolver
ensp
ENSMUSP00000178952
resolver
enst
ENSMUST00000054963
resolver
enst
ENSMUST00000224625
resolver
genesymbol
Fdft1
resolver
genesymbol_syn
Erg9
resolver
uniprot
Q8BPF5
resolver
uniprot_entry
FDFT_MOUSE
resolver
uniprot_sec
Q8BPF5
resolver
amino_acid_sequence
MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDQDSLSSSLKTCYKYLNQTSRSFAAVIQALDGDIRHAICVFYLVLRALDTVEDDMSISVEKKIPLLCNFHTFLYDPEWRFTESKEKDRQVLEDFPTISLEFRNLAEKYQTVIDDICHRMGCGMAEFVDKDVTSKQDWDKYCHYVAGLVGIGLSRLFSASEFEDPIVGEDIECANSMGLFLQKTNIIRDYLEDQQEGRKFWPQEVWGRYIKKLEDFAKPENVDVAVQCLNELITNTLQHIPDVLTYLSRLRNQSVFNFCAIPQVMAIATLAACYNNQQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIYQYIEEIYHRIPNSDPSSSKTKQVISKIRTQNLPNCQLISRSHYSPIYLSFIMLLAALSWQYLSTLSQVTEDYVQREH
uniprot
proteins
ec_number
2.5.1.21
uniprot
proteins
function
FUNCTION: Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene (PubMed:10521476). Proceeds in two distinct steps. In the first half-reaction, two molecules of FPP react to form the stable presqualene diphosphate intermediate (PSQPP), with concomitant release of a proton and a molecule of inorganic diphosphate. In the second half-reaction, PSQPP undergoes heterolysis, isomerization, and reduction with NADPH or NADH to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway (By similarity). {ECO:0000250|UniProtKB:P37268, ECO:0000269|PubMed:10521476}.
uniprot
proteins
mass_dalton
48154
uniprot
proteins
pathway_participation
PATHWAY: Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 1/3. {ECO:0000305}.
uniprot
proteins
protein_family
Phytoene/squalene synthase family
uniprot
proteins
pubmed
10521476
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7999794
uniprot
proteins
sequence_length
416
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q02769}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 284..304; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 384..404; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins