IL15
entrez
3600
canonical
uniprot
P40933
canonical
ensembl
ENSG00000164136
resolver
ensp
ENSP00000323505
resolver
ensp
ENSP00000422271
resolver
genesymbol
IL15
resolver
hgnc
HGNC:5977
resolver
uniprot
D3DNZ2
resolver
uniprot
O00440
resolver
uniprot
O43512
resolver
uniprot
Q495Z8
resolver
uniprot
Q6FGX7
resolver
uniprot
Q93058
resolver
uniprot
Q9UBA3
resolver
uniprot_entry
IL15_HUMAN
resolver
uniprot_sec
D3DNZ2
resolver
uniprot_sec
O00440
resolver
uniprot_sec
O43512
resolver
uniprot_sec
Q495Z8
resolver
uniprot_sec
Q6FGX7
resolver
uniprot_sec
Q93058
resolver
uniprot_sec
Q9UBA3
resolver
amino_acid_sequence
MRISKPHLRSISIQCYLCLLLNSHFLTEAGIHVFILGCFSAGLPKTEANWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS
uniprot
proteins
function
FUNCTION: Cytokine that plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems (PubMed:15123770). Stimulates the proliferation of natural killer cells, T-cells and B-cells and promotes the secretion of several cytokines (PubMed:8178155, PubMed:9326248). In monocytes, induces the production of IL8 and monocyte chemotactic protein 1/CCL2, two chemokines that attract neutrophils and monocytes respectively to sites of infection (PubMed:9326248). Unlike most cytokines, which are secreted in soluble form, IL15 is expressed in association with its high affinity IL15RA on the surface of IL15-producing cells and delivers signals to target cells that express IL2RB and IL2RG receptor subunits (PubMed:10233906, PubMed:23104097, PubMed:8026467). Binding to its receptor triggers the phosphorylation of JAK1 and JAK3 and the recruitment and subsequent phosphorylation of signal transducer and activator of transcription-3/STAT3 and STAT5 (PubMed:7568001). In mast cells, induces the rapid tyrosine phosphorylation of STAT6 and thereby controls mast cell survival and release of cytokines such as IL4 (By similarity). {ECO:0000250|UniProtKB:P48346, ECO:0000269|PubMed:10233906, ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:23104097, ECO:0000269|PubMed:7568001, ECO:0000269|PubMed:8026467, ECO:0000269|PubMed:8178155, ECO:0000269|PubMed:9326248}.
uniprot
proteins
mass_dalton
18086
uniprot
proteins
protein_family
IL-15/IL-21 family
uniprot
proteins
pubmed
10233906
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15123770
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21167836
uniprot
proteins
pubmed
23104097
uniprot
proteins
pubmed
7568001
uniprot
proteins
pubmed
8026467
uniprot
proteins
pubmed
8178155
uniprot
proteins
pubmed
8668345
uniprot
proteins
pubmed
8932977
uniprot
proteins
pubmed
9326248
uniprot
proteins
pubmed
9405632
uniprot
proteins
sequence_length
162
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform IL15-S48AA]: Secreted.; SUBCELLULAR LOCATION: [Isoform IL15-S21AA]: Cytoplasm. Nucleus. Note=IL15-S21AA is not secreted, but rather is stored intracellularly, appearing in the nucleus and cytoplasmic components.
uniprot
proteins