GPR75
entrez
10936
canonical
uniprot
O95800
canonical
ensembl
ENSG00000119737
resolver
ensp
ENSP00000378195
resolver
enst
ENST00000394705
resolver
genesymbol
GPR75
resolver
hgnc
HGNC:4526
resolver
uniprot
B2RC02
resolver
uniprot
Q6NWR2
resolver
uniprot_entry
GPR75_HUMAN
resolver
uniprot_sec
B2RC02
resolver
uniprot_sec
Q6NWR2
resolver
amino_acid_sequence
MNSTGHLQDAPNATSLHVPHSQEGNSTSLQEGLQDLIHTATLVTCTFLLAVIFCLGSYGNFIVFLSFFDPAFRKFRTNFDFMILNLSFCDLFICGVTAPMFTFVLFFSSASSIPDAFCFTFHLTSSGFIIMSLKTVAVIALHRLRMVLGKQPNRTASFPCTVLLTLLLWATSFTLATLATLKTSKSHLCLPMSSLIAGKGKAILSLYVVDFTFCVAVVSVSYIMIAQTLRKNAQVRKCPPVITVDASRPQPFMGVPVQGGGDPIQCAMPALYRNQNYNKLQHVQTRGYTKSPNQLVTPAASRLQLVSAINLSTAKDSKAVVTCVIIVLSVLVCCLPLGISLVQVVLSSNGSFILYQFELFGFTLIFFKSGLNPFIYSRNSAGLRRKVLWCLQYIGLGFFCCKQKTRLRAMGKGNLEVNRNKSSHHETNSAYMLSPKPQKKFVDQACGPSHSKESMVSPKISAGHQHCGQSSSTPINTRIEPYYSIYNSSPSQEESSPCNLQPVNSFGFANSYIAMHYHTTNDLVQEYDSTSAKQIPVPSV
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor. {ECO:0000250|UniProtKB:Q6X632, ECO:0000303|PubMed:23979485}.
uniprot
proteins
mass_dalton
59359
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10381362
uniprot
proteins
pubmed
11466257
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
23979485
uniprot
proteins
sequence_length
540
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 47..67; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 87..107; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 121..141; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 161..181; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 206..226; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 319..339; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 351..371; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins