Cd6
entrez
12511
canonical
uniprot
Q61003
canonical
ensembl
ENSMUSG00000024670
resolver
ensp
ENSMUSP00000046861
resolver
ensp
ENSMUSP00000079172
resolver
genesymbol
Cd6
resolver
uniprot
Q60679
resolver
uniprot
Q61004
resolver
uniprot
Q8BGK1
resolver
uniprot_entry
CD6_MOUSE
resolver
uniprot_sec
Q60679
resolver
uniprot_sec
Q61004
resolver
uniprot_sec
Q8BGK1
resolver
amino_acid_sequence
MWLFLGIAGLLTAVLSGLPSPAPSGQHKNGTIPNMTLDLEERLGIRLVNGSSRCSGSVKVLLESWEPVCAAHWNRAATEAVCKALNCGDSGKVTYLMPPTSELPPGATSGNTSSAGNTTWARAPTERCRGANWQFCKVQDQECSSDRRLVWVTCAENQAVRLVDGSSRCAGRVEMLEHGEWGTVCDDTWDLQDAHVVCKQLKCGWAVKALAGLHFTPGQGPIHRDQVNCSGTEAYLWDCPGRPGDQYCGHKEDAGVVCSEHQSWRLTGGIDSCEGQVEVYFRGVWSTVCDSEWYPSEAKVLCRSLGCGSAVARPRGLPHSLDGRMYYSCKGQEPALSTCSWRFNNSNLCSQSRAARVVCSGSQRHLNLSTSEVPSRVPVTIESSVPVSVKDKDSQGLTLLILCIVLGILLLVSTIFIVILLLRAKGQYALPASVNHQQLSTANQAGINNYHPVPITIAKEAPMLFIQPRVPADSDSSSDSDYEHYDFSSQPPVALTTFYNSQRHRVTEEEAQQNRFQMPPLEEGLEELHVSHIPAADPRPCVADVPSRGSQYHVRNNSDSSTSSEEGYCNDPSSKPPPWNSQAFYSEKSPLTEQPPNLELAGSPAVFSGPSADDSSSTSSGEWYQNFQPPPQHPPAEQFECPGPPGPQTDSIDDDEEDYDDIGAA
uniprot
proteins
function
FUNCTION: Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166. Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089). Functions as a costimulatory molecule; promotes T-cell activation and proliferation. Contributes to the formation and maturation of the immunological synapse. Functions as a calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria. LPS binding leads to the activation of signaling cascades and down-stream MAP kinases. Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS. {ECO:0000250|UniProtKB:P30203, ECO:0000269|PubMed:24584089}.
uniprot
proteins
mass_dalton
72255
uniprot
proteins
post_translational_modification
PTM: After T-cell activation, becomes hyperphosphorylated on Ser and Thr residues (By similarity). Phosphorylated on tyrosine residues in response to stimulation of the TCR complex (PubMed:24584089). {ECO:0000250|UniProtKB:P30203, ECO:0000269|PubMed:24584089}.; PTM: Glycosylated. {ECO:0000250|UniProtKB:P30203}.
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16914752
uniprot
proteins
pubmed
24584089
uniprot
proteins
pubmed
7594475
uniprot
proteins
pubmed
7870060
uniprot
proteins
sequence_length
665
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16914752}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P30203}. Note=Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells. Colocalizes with the TCR/CD3 complex at the immunological synapse. {ECO:0000250|UniProtKB:P30203}.
uniprot
proteins
transmembrane_region
TRANSMEM 399..419; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins