Grin3b
entrez
170796
canonical
uniprot
Q8VHN2
canonical
ensembl
ENSRNOG00000012562
resolver
ensp
ENSRNOP00000017064
resolver
genesymbol
Grin3b
resolver
uniprot_entry
NMD3B_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Excitatory glycine receptors are inhibited by D-serine at a concentrion of 100uM. {ECO:0000269|PubMed:11823786}.
uniprot
proteins
amino_acid_sequence
MESVRTLWLSVALALAVGSRVVRGHPQPCRVPTRAGASVRLAALLPRAPAARARVLAALATPAPRLPHNLSLELVAVASPTRDPASLARGLCQVLAPPGVVASIAFPEARPELRLLQFLAAATETPVVSVLRREVRTALGAPTPFHLQLDWASPLETILDVLVSLVRAHAWEDIALVLCRVRDPGSLVTLWTNHASQAPKFVLDLSRLDSRNDSLRAGLALLGALEGGGTPVPAAVLLGCSTARAHEVLEAAPPGPQWLLGTPLPAEALPTTGLPPGVLALGETEQHSLEAVVHDMVELVAQALSSMALVHPERALLPAVVNCDDLKTGGSEATGRTLARFLGNTSFQGRTGAVWVTGSSQVHVSRHFKVWSLRRDPLGAPAWATVGSWQDGQLDFQPGAAALRVPSPSGTQARPKLRVVTLVEHPFVFTRESDEDGQCPAGQLCLDPGTNDSARLDALFAALVNGSVPRTLRRCCYGYCIDLLERLAEDLAFDFELYIVGDGKYGALRDGRWTGLVGDLLAGRAHMAVTSFSINSARSQVVDFTSPFFSTSLGIMVRTRDTASPIGAFMWPLHWSMWVGVFAALHLTALFLTLYEWRSPYGLTPRGRNRGTVFSYSSALNLCYAILFGRTVSSKTPKCPTGRFLMNLWAIFCLLVLSSYTANLAAVMVGDKTFEELSGIHDPKLHHPSQGFRFGTVWESSAEAYIKASFPEMHAHMRRHSAPTTPHGVAMLTSDPPKLNAFIMDKSLLDYEVSIDADCKLLTVGKPFAIEGYGIGLPQNSPLTSNLSEFISRYKSSGFIDLLHDKWYKMVPCGKRVFAVTETLQMGVYHFSGLFVLLCLGLGSALLTSLGEHVFYRLVLPRIRRGNKLQYWLHTSQKIHRALNTGPPEGQQERAEQERSGPKDELPATDGAGRWRRVRRAVERERRVRFLLEPGEAGGDRPWLCSNGPGLQAELRELELRIEAARERLRSALLRRGELRALLGDGTRLRPLRLLHAAPAES
uniprot
proteins
function
FUNCTION: Component of a non-conventional N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with low calcium permeability and low voltage-dependent block by Mg(2+) (PubMed:11823786). Forms glutamatergic receptor complexes with GluN1 and GluN2 subunits which are activated by glycine binding to the GluN1 and GluN3 subunits and L-glutamate binding to GluN2 subunits (By similarity). Forms excitatory glycinergic receptor complexes with GluN1 alone which are activated by glycine binding to the GluN1 and GluN3 subunits (PubMed:11823786). GluN3B subunit also binds D-serine and, in the absence of glycine, activates glycinergic receptor complexes, but with lower efficacy than glycine (PubMed:11823786, PubMed:18636091). Each GluN3 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (By similarity). {ECO:0000250|UniProtKB:Q91ZU9, ECO:0000269|PubMed:11823786, ECO:0000269|PubMed:18636091}.
uniprot
proteins
mass_dalton
109158
uniprot
proteins
protein_family
Glutamate-gated ion channel (TC 1.A.10.1) family
uniprot
proteins
protein_family
NR3B/GRIN3B subfamily
uniprot
proteins
pubmed
11735224
uniprot
proteins
pubmed
11823786
uniprot
proteins
pubmed
18636091
uniprot
proteins
sequence_length
1002
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q91ZU9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q13224}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q91ZU9}. Note=Requires the presence of GRIN1 to be targeted at the plasma membrane. {ECO:0000250|UniProtKB:Q91ZU9}.
uniprot
proteins
transmembrane_region
TRANSMEM 575..594; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13224"; TRANSMEM 642..661; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13224"; TRANSMEM 833..848; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13224
uniprot
proteins