Neu4
entrez
241159
canonical
uniprot
Q8BZL1
canonical
ensembl
ENSMUSG00000034000
resolver
ensp
ENSMUSP00000051151
resolver
ensp
ENSMUSP00000140127
resolver
genesymbol
Neu4
resolver
uniprot
C5NTX9
resolver
uniprot
Q6NS66
resolver
uniprot_entry
C5NTX9_MOUSE
resolver
uniprot_entry
NEUR4_MOUSE
resolver
uniprot_sec
Q6NS66
resolver
amino_acid_sequence
MGPTRVPRRTVLFQRERTGLTYRVPALLCVPPRPTLLAFAEQRLSPDDSHAHRLVLRRGTLTRGSVRWGTLSVLETAVLEEHRSMNPCPVLDEHSGTIFLFFIAVLGHTPEAVQIATGKNAARLCCVTSCDAGLTWGSVRDLTEEAIGAALQDWATFAVGPGHGVQLRSGRLLVPAYTYHVDRRECFGKICWTSPHSLAFYSDDHGISWHCGGLVPNLRSGECQLAAVDGDFLYCNARSPLGNRVQALSADEGTSFLPGELVPTLAETARGCQGSIVGFLAPPSIEPQDDRWTGSPRNTPHSPCFNLRVQESSGEGARGLLERWMPRLPLCYPQSRSPENHGLEPGSDGDKTSWTPECPMSSDSMLQSPTWLLYSHPAGRRARLHMGIYLSRSPLDPHSWTEPWVIYEGPSGYSDLAFLGPMPGASLVFACLFESGTRTSYEDISFCLFSLADVLENVPTGLEMLSLRDKAQGHCWPS
uniprot
proteins
ec_number
3.2.1.18
uniprot
proteins
function
FUNCTION: Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosaccharides. Efficiently hydrolyzes gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:19506080, PubMed:22393058). Hydrolyzes poly-alpha-(2->8)-sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons (PubMed:19506080, PubMed:22393058). May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation (By similarity). Has sialidase activity toward mucin, fetuin and sialyllactose (PubMed:19506080, PubMed:22393058). {ECO:0000250|UniProtKB:Q8WWR8, ECO:0000269|PubMed:19506080, ECO:0000269|PubMed:22393058}.
uniprot
proteins
mass_dalton
52426
uniprot
proteins
protein_family
Glycosyl hydrolase 33 family
uniprot
proteins
pubmed
14637003
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19506080
uniprot
proteins
pubmed
22393058
uniprot
proteins
sequence_length
478
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22393058}; Peripheral membrane protein. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8WWR8}; Peripheral membrane protein. Microsome membrane {ECO:0000250|UniProtKB:Q8WWR8}; Peripheral membrane protein. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q8WWR8}; Peripheral membrane protein. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8WWR8}; Peripheral membrane protein. Cell projection, neuron projection {ECO:0000269|PubMed:22393058}. Lysosome lumen {ECO:0000250|UniProtKB:Q8WWR8}.
uniprot
proteins