ACER2
entrez
340485
canonical
uniprot
Q5QJU3
canonical
ensembl
ENSG00000177076
resolver
ensp
ENSP00000342609
resolver
genesymbol
ACER2
resolver
genesymbol_syn
ASAH3L
resolver
hgnc
HGNC:23675
resolver
uniprot
A2A3R8
resolver
uniprot
B3KVV5
resolver
uniprot
Q569G5
resolver
uniprot
Q5VZR7
resolver
uniprot
Q71RD2
resolver
uniprot_entry
ACER2_HUMAN
resolver
uniprot_entry
B3KVV5_HUMAN
resolver
uniprot_sec
A2A3R8
resolver
uniprot_sec
Q569G5
resolver
uniprot_sec
Q5VZR7
resolver
uniprot_sec
Q71RD2
resolver
activity_regulation
ACTIVITY REGULATION: Specifically activated by lumenal, but not cytosolic Ca(2+). Inhibited by Zn(2+) or Cu(2+). Mg(2+) or Mn(2+) have no effect on ceramidase activity (PubMed:20089856). Inhibited by De-MAPP (PubMed:20207939). {ECO:0000269|PubMed:20089856, ECO:0000269|PubMed:20207939}.
uniprot
proteins
amino_acid_sequence
MGAPHWWDQLQAGSSEVDWCEDNYTIVPAIAEFYNTISNVLFFILPPICMCLFRQYATCFNSGIYLIWTLLVVVGIGSVYFHATLSFLGQMLDELAVLWVLMCALAMWFPRRYLPKIFRNDRGRFKVVVSVLSAVTTCLAFVKPAINNISLMTLGVPCTALLIAELKRCDNMRVFKLGLFSGLWWTLALFCWISDRAFCELLSSFNFPYLHCMWHILICLAAYLGCVCFAYFDAASEIPEQGPVIKFWPNEKWAFIGVPYVSLLCANKKSSVKIT
uniprot
proteins
ec_number
3.5.1.-
uniprot
proteins
ec_number
3.5.1.23
uniprot
proteins
function
FUNCTION: Golgi ceramidase that catalyzes the hydrolysis of ceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH (PubMed:16940153, PubMed:18945876, PubMed:20089856, PubMed:20207939). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:20207939). Has a better catalytic efficiency towards unsaturated long-chain ceramides, including C18:1-, C20:1- and C24:1-ceramides (PubMed:16940153, PubMed:18945876, PubMed:20089856, PubMed:20207939). Saturated long-chain ceramides and unsaturated very long-chain ceramides are also good substrates, whereas saturated very long-chain ceramides and short-chain ceramides are poor substrates (PubMed:20089856). Also hydrolyzes dihydroceramides to produce dihydrosphingosine (PubMed:20207939, PubMed:20628055). It is the ceramidase that controls the levels of circulating sphingosine-1-phosphate and dihydrosphingosine-1-phosphate in plasma through their production by hematopoietic cells (By similarity). Regulates cell proliferation, autophagy and apoptosis by the production of sphingosine and sphingosine-1-phosphate (PubMed:16940153, PubMed:26943039, PubMed:28294157, PubMed:29229990). As part of a p53/TP53-dependent pathway, promotes for instance autophagy and apoptosis in response to DNA damage (PubMed:26943039, PubMed:28294157, PubMed:29229990). Through the production of sphingosine, may also regulate the function of the Golgi complex and regulate the glycosylation of proteins (PubMed:18945876). {ECO:0000250|UniProtKB:Q8VD53, ECO:0000269|PubMed:16940153, ECO:0000269|PubMed:18945876, ECO:0000269|PubMed:20089856, ECO:0000269|PubMed:20207939, ECO:0000269|PubMed:20628055, ECO:0000269|PubMed:26943039, ECO:0000269|PubMed:28294157, ECO:0000269|PubMed:29229990, ECO:0000303|PubMed:20207939}.
uniprot
proteins
mass_dalton
31309
uniprot
proteins
mutagenesis
MUTAGEN 1..16; /note="Missing: Loss of localization to the Golgi. No effect on the ceramidase activity."; /evidence="ECO:0000269|PubMed:20089856
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; sphingolipid metabolism. {ECO:0000269|PubMed:16940153, ECO:0000269|PubMed:20089856, ECO:0000269|PubMed:20207939}.
uniprot
proteins
protein_family
Alkaline ceramidase family
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
16940153
uniprot
proteins
pubmed
18945876
uniprot
proteins
pubmed
20089856
uniprot
proteins
pubmed
20207939
uniprot
proteins
pubmed
20628055
uniprot
proteins
pubmed
26943039
uniprot
proteins
pubmed
28294157
uniprot
proteins
pubmed
29229990
uniprot
proteins
sequence_length
275
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:16940153, ECO:0000269|PubMed:20089856}; Multi-pass membrane protein {ECO:0000269|PubMed:20089856}.
uniprot
proteins
transmembrane_region
TRANSMEM 33..53; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 63..83; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 87..107; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 125..142; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 144..164; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 174..194; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 212..232; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins