Gapvd1
entrez
66691
canonical
uniprot
Q6PAR5
canonical
ensembl
ENSMUSG00000026867
resolver
ensp
ENSMUSP00000028224
resolver
ensp
ENSMUSP00000099864
resolver
ensp
ENSMUSP00000108723
resolver
ensp
ENSMUSP00000108725
resolver
ensp
ENSMUSP00000108735
resolver
ensp
ENSMUSP00000221680
resolver
ensp
ENSMUSP00000221682
resolver
ensp
ENSMUSP00000221683
resolver
ensp
ENSMUSP00000339045
resolver
genesymbol
Gapvd1
resolver
genesymbol_syn
Gapex5
resolver
genesymbol_syn
Kiaa1521
resolver
uniprot
A0PJI8
resolver
uniprot
A2AR09
resolver
uniprot
A2AR10
resolver
uniprot
A2AR17
resolver
uniprot
A2AR18
resolver
uniprot
Q3TNS1
resolver
uniprot
Q3UDL0
resolver
uniprot
Q3UYD5
resolver
uniprot
Q6ZPP0
resolver
uniprot
Q80V37
resolver
uniprot
Q80ZK4
resolver
uniprot
Q8BTS5
resolver
uniprot
Q9CRS2
resolver
uniprot
Q9CTI1
resolver
uniprot_entry
GAPD1_MOUSE
resolver
uniprot_sec
A0PJI8
resolver
uniprot_sec
A2AR09
resolver
uniprot_sec
A2AR10
resolver
uniprot_sec
A2AR17
resolver
uniprot_sec
A2AR18
resolver
uniprot_sec
Q3TNS1
resolver
uniprot_sec
Q3UDL0
resolver
uniprot_sec
Q3UYD5
resolver
uniprot_sec
Q6ZPP0
resolver
uniprot_sec
Q80V37
resolver
uniprot_sec
Q80ZK4
resolver
uniprot_sec
Q8BTS5
resolver
uniprot_sec
Q9CRS2
resolver
uniprot_sec
Q9CTI1
resolver
amino_acid_sequence
MVKLDIHTLAHHLKQERLYVSSEKQLIQRLNADVLKTAEKLYRTAWIAKQQRINLDRLIITSAEASPAECCQHAKILEDTQFVDGYKQLGFQETAYGEFLSRLRENPRLIASSLVAGEKLNQENTQSVIYTVFTSLYGNCIMQEDESYLLQVLRYLIEFELKESDNPRRLLRRGTCAFSILFKLFSEGLFSAKLFLTATLHEPIMQLLVEDEDHLETDPNKLIERFSPAQQEKLFGEKGSDRFRQKVQEMVDSNEAKLVALVNKFIGYLKQNTYCFPHSLRWIVSQMYKTLSCVDRLEVGEVRAMCTDLLLACFICPAVVNPEQYGIISDAPINEVARFNLMQVGRLLQQLAMTGTEEGDPRTKNSLGKFDKGCVAAFLDVVIGGRAVETPPMSSVNLLEGLSRTVVYISYSQLITLVNFMKSVMSGDQLKEDRMALDNLLANLPQAKPGKSSSLDMTPYSTPQMSPATTPANKKNRLPIATRSRSRSNMLMDLHMDHEGSSQETIQEVQPEEVLVISLGTGPQLTPGMMSENEVLNMQLSDGGQGDVPVDENKLHGKPDKTLRFSLCSDNLEGISEGPSNRSNSVSSLDLEGESVSELGAGPSGSNGVEALQLLEHEQATTQDNLDDKLRKFEIRDMMGLTDDRDISETVSETWSTDVLGSDFDPNVDEDRLQEIAGAAAENVLGSLLCLPGSGSVLLDPCTGSTISETTSEAWSVEVLPSDSEAPDLKQEERLQELESCSGLGSTSDDTDVREVSSRPSTPGLSVVSGISATSEDIPNKIEDLRSECSSDFGGKDSVTSPDMDDIAHGAHQLTSPPSQSESLLAMFDPLSSHEGASAVVRPKVHYARPSHPPPDPPILEGAVGGNEARLPNFGSHVLTAAEMEAFKQRHSYPERLVRSRSSDIVSSVRRPMSDPSWNRRPGNEELPPAAATGATSLVAAPHSSSSSPSKDSSRGETEERKDSDDERSDRSRPWWRKRFVSAMPKAPIPFRKKEKQEKDKDDLGPDRFSTLTDEPSPRLSAQAQVAEDILDKYRNAIKRTSPSEGAMANDESAEVMGDGESAHDSPREEALQNISADDLPDSASQAAHPQDSAFSYRDVKKKLRLALCSADSVAFPVLTHSTRNGLPDHTDPEDNEIVCFLKVQIAEAINLQDKSLMAQLQETMRCVCRFDNRTCRKLLASIAEDYRKRAPYIAYLTRCRQGLQTTQAHLERLLQRVLRDKEVANRYFTTVCVRLLLESKEKKIREFIQDFQKLTAADDKTAQVEDFLQFLYGVMAQDVIWQNASEEQLQDAQLAIERSVMNRIFKLAFYPNQDGDILRDQVLHEHIQRLSKVVTANHRALQIPEVYLREAPWPSAQSEIRTISAYKTPRDKVQCILRMCSTIMNLLSLANEDSVPGADDFVPVLVFVLIKANPPCLLSTVQYISSFYASCLSGEESYWWMQFTAAVEFIKTIDDRK
uniprot
proteins
function
FUNCTION: Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras. {ECO:0000269|PubMed:16880210, ECO:0000269|PubMed:17189207, ECO:0000269|PubMed:17545148}.
uniprot
proteins
mass_dalton
162402
uniprot
proteins
protein_family
GAPVD1 family
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16880210
uniprot
proteins
pubmed
17189207
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17545148
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1458
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:17189207}; Peripheral membrane protein {ECO:0000269|PubMed:17189207}. Endosome {ECO:0000250}. Note=Recruited to the plasma membrane by TRIP10/CIP4 in response to insulin.
uniprot
proteins