KIF20B
entrez
9585
canonical
uniprot
Q96Q89
canonical
ensembl
ENSG00000138182
resolver
ensp
ENSP00000260753
resolver
ensp
ENSP00000360793
resolver
genesymbol
KIF20B
resolver
genesymbol_syn
KRMP1
resolver
genesymbol_syn
MPHOSPH1
resolver
hgnc
HGNC:7212
resolver
uniprot
A8MXM7
resolver
uniprot
O43277
resolver
uniprot
Q09471
resolver
uniprot
Q2KQ73
resolver
uniprot
Q32NE1
resolver
uniprot
Q561V3
resolver
uniprot
Q58EX8
resolver
uniprot
Q5T9M8
resolver
uniprot
Q5T9M9
resolver
uniprot
Q5T9N0
resolver
uniprot
Q5T9N1
resolver
uniprot
Q7KZ68
resolver
uniprot
Q7Z5E0
resolver
uniprot
Q7Z5E1
resolver
uniprot
Q7Z6M9
resolver
uniprot
Q86X82
resolver
uniprot
Q9H3R8
resolver
uniprot
Q9H6Q9
resolver
uniprot
Q9H755
resolver
uniprot
Q9NTC1
resolver
uniprot
Q9UFR5
resolver
uniprot_entry
KI20B_HUMAN
resolver
uniprot_sec
A8MXM7
resolver
uniprot_sec
O43277
resolver
uniprot_sec
Q09471
resolver
uniprot_sec
Q2KQ73
resolver
uniprot_sec
Q32NE1
resolver
uniprot_sec
Q561V3
resolver
uniprot_sec
Q58EX8
resolver
uniprot_sec
Q5T9M8
resolver
uniprot_sec
Q5T9M9
resolver
uniprot_sec
Q5T9N0
resolver
uniprot_sec
Q5T9N1
resolver
uniprot_sec
Q7KZ68
resolver
uniprot_sec
Q7Z5E0
resolver
uniprot_sec
Q7Z5E1
resolver
uniprot_sec
Q7Z6M9
resolver
uniprot_sec
Q86X82
resolver
uniprot_sec
Q9H3R8
resolver
uniprot_sec
Q9H6Q9
resolver
uniprot_sec
Q9H755
resolver
uniprot_sec
Q9NTC1
resolver
uniprot_sec
Q9UFR5
resolver
amino_acid_sequence
MESNFNQEGVPRPSYVFSADPIARPSEINFDGIKLDLSHEFSLVAPNTEANSFESKDYLQVCLRIRPFTQSEKELESEGCVHILDSQTVVLKEPQCILGRLSEKSSGQMAQKFSFSKVFGPATTQKEFFQGCIMQPVKDLLKGQSRLIFTYGLTNSGKTYTFQGTEENIGILPRTLNVLFDSLQERLYTKMNLKPHRSREYLRLSSEQEKEEIASKSALLRQIKEVTVHNDSDDTLYGSLTNSLNISEFEESIKDYEQANLNMANSIKFSVWVSFFEIYNEYIYDLFVPVSSKFQKRKMLRLSQDVKGYSFIKDLQWIQVSDSKEAYRLLKLGIKHQSVAFTKLNNASSRSHSIFTVKILQIEDSEMSRVIRVSELSLCDLAGSERTMKTQNEGERLRETGNINTSLLTLGKCINVLKNSEKSKFQQHVPFRESKLTHYFQSFFNGKGKICMIVNISQCYLAYDETLNVLKFSAIAQKVCVPDTLNSSQEKLFGPVKSSQDVSLDSNSNSKILNVKRATISWENSLEDLMEDEDLVEELENAEETQNVETKLLDEDLDKTLEENKAFISHEEKRKLLDLIEDLKKKLINEKKEKLTLEFKIREEVTQEFTQYWAQREADFKETLLQEREILEENAERRLAIFKDLVGKCDTREEAAKDICATKVETEETHNYVGFEDIIDSLQDNVADIKKQAEIAHLYIASLPDPQEATACLELKFNQIKAELAKTKGELIKTKEELKKRENESDSLIQELETSNKKIITQNQRIKELINIIDQKEDTINEFQNLKSHMENTFKCNDKADTSSLIINNKLICNETVEVPKDSKSKICSERKRVNENELQQDEPPAKKGSIHVSSAITEDQKKSEEVRPNIAEIEDIRVLQENNEGLRAFLLTIENELKNEKEEKAELNKQIVHFQQELSLSEKKNLTLSKEVQQIQSNYDIAIAELHVQKSKNQEQEEKIMKLSNEIETATRSITNNVSQIKLMHTKIDELRTLDSVSQISNIDLLNLRDLSNGSEEDNLPNTQLDLLGNDYLVSKQVKEYRIQEPNRENSFHSSIEAIWEECKEIVKASSKKSHQIEELEQQIEKLQAEVKGYKDENNRLKEKEHKNQDDLLKEKETLIQQLKEELQEKNVTLDVQIQHVVEGKRALSELTQGVTCYKAKIKELETILETQKVECSHSAKLEQDILEKESIILKLERNLKEFQEHLQDSVKNTKDLNVKELKLKEEITQLTNNLQDMKHLLQLKEEEEETNRQETEKLKEELSASSARTQNLKADLQRKEEDYADLKEKLTDAKKQIKQVQKEVSVMRDEDKLLRIKINELEKKKNQCSQELDMKQRTIQQLKEQLNNQKVEEAIQQYERACKDLNVKEKIIEDMRMTLEEQEQTQVEQDQVLEAKLEEVERLATELEKWKEKCNDLETKNNQRSNKEHENNTDVLGKLTNLQDELQESEQKYNADRKKWLEEKMMLITQAKEAENIRNKEMKKYAEDRERFFKQQNEMEILTAQLTEKDSDLQKWREERDQLVAALEIQLKALISSNVQKDNEIEQLKRIISETSKIETQIMDIKPKRISSADPDKLQTEPLSTSFEISRNKIEDGSVVLDSCEVSTENDQSTRFPKPELEIQFTPLQPNKMAVKHPGCTTPVTVKIPKARKRKSNEMEEDLVKCENKKNATPRTNLKFPISDDRNSSVKKEQKVAIRPSSKKTYSLRSQASIIGVNLATKKKEGTLQKFGDFLQHSPSILQSKAKKIIETMSSSKLSNVEASKENVSQPKRAKRKLYTSEISSPIDISGQVILMDQKMKESDHQIIKRRLRTKTAK
uniprot
proteins
function
FUNCTION: Plus-end-directed motor enzyme that is required for completion of cytokinesis (PubMed:11470801, PubMed:12740395). Required for proper midbody organization and abscission in polarized cortical stem cells. Plays a role in the regulation of neuronal polarization by mediating the transport of specific cargos. Participates in the mobilization of SHTN1 and in the accumulation of PIP3 in the growth cone of primary hippocampal neurons in a tubulin and actin-dependent manner. In the developing telencephalon, cooperates with SHTN1 to promote both the transition from the multipolar to the bipolar stage and the radial migration of cortical neurons from the ventricular zone toward the superficial layer of the neocortex. Involved in cerebral cortex growth (By similarity). Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). {ECO:0000250|UniProtKB:Q80WE4, ECO:0000269|PubMed:11470801, ECO:0000269|PubMed:12740395, ECO:0000269|PubMed:17409436}.
uniprot
proteins
mass_dalton
210629
uniprot
proteins
post_translational_modification
PTM: Phosphorylated during mitosis by CDK1 (PubMed:11470801, PubMed:12740395). {ECO:0000269|PubMed:11470801, ECO:0000269|PubMed:12740395}.
uniprot
proteins
protein_family
Kinesin family
uniprot
proteins
protein_family
TRAFAC class myosin-kinesin ATPase superfamily
uniprot
proteins
pubmed
10695267
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
11470801
uniprot
proteins
pubmed
12740395
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17409436
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26477546
uniprot
proteins
pubmed
8290587
uniprot
proteins
sequence_length
1820
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12740395, ECO:0000269|PubMed:17409436}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:11470801}. Nucleus, nucleolus {ECO:0000269|PubMed:11470801}. Nucleus, nucleoplasm {ECO:0000269|PubMed:11470801}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11470801, ECO:0000269|PubMed:12740395}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:11470801}. Midbody {ECO:0000269|PubMed:12740395, ECO:0000269|PubMed:17409436}. Cell projection, axon {ECO:0000250|UniProtKB:Q80WE4}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q80WE4}. Note=Localizes mainly in the nucleus during interphase although it is also detected in the cytoplasm without clear association with microtubules (PubMed:12740395). Localized to the central spindle during cytokinetic furrowing and with the midbody during abscission (PubMed:12740395, PubMed:17409436). A 2-3 fold expression increase is seen as cells progress from G1 to G2/M phase (PubMed:12740395). During prophase and metaphase it is found throughout the cytoplasm and at anaphase accumulates at the midplan of the cell and forms a distinct band extending across the spindle midzone (PubMed:12740395). At anaphase it is concentrated in the midbody (PubMed:12740395). Colocalized partially along microtubules in primary neurons. Colocalized with SHTN1 along microtubules to the tip of the growing cone in primary hippocampal neurons. Localized in midbodies between dividing radial progenitors in the ventricular zone (By similarity). Colocalized with PRC1 in the nucleus of bladder carcinoma cells at the interphase. Colocalized with PRC1 in bladder carcinoma cells at prophase, metaphase, early anaphase, at the midzone in late anaphase and at the contractile ring in telophase (PubMed:17409436). {ECO:0000250|UniProtKB:Q80WE4, ECO:0000269|PubMed:12740395, ECO:0000269|PubMed:17409436}.
uniprot
proteins