Q69ZJ7
uniprot
Q69ZJ7
canonical
amino_acid_sequence
MYFLSGWPKRLLCAPRSPAEAPLHVQSDPRRAFFAVLAPARLSIWYSRPSVLIVTYKEPAKSSTQFGSYKQAEWRPDSTMIAVSTANGYILFFHITSSRGDKYLYEPVYPKGSPQMKGIPHFKEEHCAPALNLEMKKILDLQAPIMSLQSVLEDLLVATSDGLLHLIHWEGMTNGRKAINLSTVPFSVDLQSSRVGSFLGFADVHIKDMEYCATLDGFAVVFNDGKVGFITPVSSRFTAEQLHGVWPQDVIDGTCVAVNNKYRLMAFGCASGCVQVYTIDNTTGAMLLSHKLELTAKQYPDIWNKTGAVKLIRWSPDNSAVIVTWEYGGLSLWSVFGAQLICTLGGDFAYRSDGTKKDPLKINSMSWGAEGYHLWVISGLGSQHTQIETDLRSTVKEPSILLFQFIKSVLTVNPCMSNQEQVLLQGEDRLYLNCGEASQAQNPKYSSARAERMPRHEKSPFADGGLEAPGLSTLLGHRHWHVVQISSTYLESNWPIRFSAIDKLGQNIAVAGKFGFAHYSLLTKKWKLFGNITQEQNMIVTGGLAWWDDFMVLACYNLSDCQEELRIYLRTSNLDNAFAHVTKAPMETLLLSVFRDMVVVFRADCSICLYSIERKSDGSNTTASVQVLQEVSMSRYIPHPFLVVSVTLTSVSTENGISLKMPQQARDAESIMLNLAGQLIMMQRDRSGPQIREKDSHPNQRKLLPFCPPVVLAQSVENVWTTCRANKQKRHLLEALWLSCGGAGMKVWLPLFPRDHRKPHSFLSQRIMLPFHINIYPLAVLFEDALVLGAVNDTLLYDSLYTRSSAREQLEVLFPFCVVERTSQIYLHHILRQLLVRNLGEQALLLAQSCAALPYFPHVLELMLHEVLEEEATSREPIPDPLLPTVAKFITEFPLFLQTVVHCARKTEYALWNYLFAAVGNPKDLFEECLMAQDLDTAASYLIILQNMEVPAVSRQHATLLFNTALEQGKWDLCRHMIRFLKAIGSGESETPPSTPTSQEPSSSGGFEFFRNRSISLSQSAENVPPGKFGLQKTLSMPTGPSGKRWSKDSECAENMYIDMMLWRHARRLLEEVRLKDLGCFAAQLGFELISWLCKERTRAARVDNFVVALKRLHKDFLWPLPIIPASSISSPFKNGKCRAVGEQMLKSQSADPFITPEMDAGISNIQRSQSWLSNIGPTHRDTDRASSPGPQMQDAFLSPLSNKGDECSIGSATDLTESSSVVDGDWTMVDENFSTLSLTQSELEHISMELASKGPHKSQVQLRYLLHIFMEAGCLDWCVVIGLILRESSVVSQLLGIAQSSEMDGEMLQNIKSGLQAVDRWASTDCPGYKPFLNIIKPQLQKLSEITEELVQPDTFQPVTVGKTPEQTSPRAEENRGSCSHGSISQSEPGSNNVVSRKEEDTTQADEEEPLQDGAYDCSVS
uniprot
proteins
function
FUNCTION: The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP, and may thereby be required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1. Is a regulator of procollagen transport and secretion, and is required for correct cartilage morphogenesis and development of the craniofacial skeleton. {ECO:0000250|UniProtKB:Q4ADV7}.
uniprot
proteins
mass_dalton
158829
uniprot
proteins
protein_family
RIC1 family
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27878435
uniprot
proteins
sequence_length
1422
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q4ADV7}. Membrane {ECO:0000250|UniProtKB:Q4ADV7}.
uniprot
proteins