Got1
entrez
14718
canonical
uniprot
P05201
canonical
ensembl
ENSMUSG00000025190
resolver
ensp
ENSMUSP00000026196
resolver
enst
ENSMUST00000026196
resolver
genesymbol
Got1
resolver
uniprot
Q3UJH8
resolver
uniprot_entry
AATC_MOUSE
resolver
uniprot_sec
Q3UJH8
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by calcium ions. {ECO:0000269|PubMed:21937432}.
uniprot
proteins
amino_acid_sequence
MAPPSVFAQVPQAPPVLVFKLTADFRDDPDPRKVNLGVGAYRTDESQPWVLPVVRKVEQKIANDNSLNHEYLPILGLAEFRSCASRLVLGDNSLAIRENRVGGVQSLGGTGALRIGADFLGRWYNGTDNKNTPIYVSSPTWENHNAVFSAAGFKDIRPYCYWDAEKRGLDLQGFLNDLENAPEFSIFVLHACAHNPTGTDPTPEQWKQIAAVMQRRFLFPFFDSAYQGFASGDLEKDAWAIRYFVSEGFELFCAQSFSKNFGLYNERVGNLTVVGKESDSVLRVLSQMEKIVRITWSNPPAQGARIVAATLSDPELFKEWKGNVKTMADRILTMRSELRARLEALKTPGTWSHITEQIGMFSFTGLNPKQVEYLVNEKHIYLLPSGRINMCGLTTKNLDYVATSIHEAVTKIQ
uniprot
proteins
ec_number
2.6.1.1
uniprot
proteins
ec_number
2.6.1.3
uniprot
proteins
function
FUNCTION: Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. {ECO:0000250|UniProtKB:P13221}.
uniprot
proteins
mass_dalton
46248
uniprot
proteins
protein_family
Class-I pyridoxal-phosphate-dependent aminotransferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21937432
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
3379636
uniprot
proteins
pubmed
3782150
uniprot
proteins
sequence_length
413
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins