Nr3c1
entrez
24413
canonical
uniprot
P06536
canonical
ensembl
ENSRNOG00000014096
resolver
ensp
ENSRNOP00000044335
resolver
ensp
ENSRNOP00000108341
resolver
enst
ENSRNOT00000044287
resolver
genesymbol
Nr3c1
resolver
genesymbol_syn
Grl
resolver
uniprot
E9PT44
resolver
uniprot
O08624
resolver
uniprot
Q8R463
resolver
uniprot
Q8R5J0
resolver
uniprot_entry
E9PT44_RAT
resolver
uniprot_entry
GCR_RAT
resolver
uniprot_sec
O08624
resolver
uniprot_sec
Q8R463
resolver
uniprot_sec
Q8R5J0
resolver
amino_acid_sequence
MDSKESLAPPGRDEVPGSLLGQGRGSVMDFYKSLRGGATVKVSASSPSVAAASQADSKQQRILLDFSKGSTSNVQQRQQQQQQQQQQQQQQQQQQQPDLSKAVSLSMGLYMGETETKVMGNDLGYPQQGQLGLSSGETDFRLLEESIANLNRSTSVPENPKSSTSATGCATPTEKEFPKTHSDASSEQQNRKSQTGTNGGSVKLYPTDQSTFDLLKDLEFSAGSPSKDTNESPWRSDLLIDENLLSPLAGEDDPFLLEGNTNEDCKPLILPDTKPKIKDTGDTILSSPSSVALPQVKTEKDDFIELCTPGVIKQEKLGPVYCQASFSGTNIIGNKMSAISVHGVSTSGGQMYHYDMNTASLSQQQDQKPVFNVIPPIPVGSENWNRCQGSGEDSLTSLGALNFPGRSVFSNGYSSPGMRPDVSSPPSSSSAATGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATAGVSQDTSENPNKTIVPAALPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSAWRIMTTLNMLGGRQVIAAVKWAKAILGLRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSGNLLCFAPDLIINEQRMSLPCMYDQCKHMLFVSSELQRLQVSYEEYLCMKTLLLLSSVPKEGLKSQELFDEIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSMHEVVENLLTYCFQTFLDKTMSIEFPEMLAEIITNQIPKYSNGNIKKLLFHQK
uniprot
proteins
function
FUNCTION: Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:12917342). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (By similarity). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). In response to induction by transcription factor EGR1/NGFI-A in the hippocampus, may play a role in the behavioral and hypothalamic-pituitary-adrenal responses to stress in offspring (PubMed:15220929). {ECO:0000250|UniProtKB:P04150, ECO:0000250|UniProtKB:P06537, ECO:0000269|PubMed:12917342}.; FUNCTION: [Isoform A]: Has transcriptional activation and repression activity. Mediates glucocorticoid-induced apoptosis. Promotes accurate chromosome segregation during mitosis. May act as a tumor suppressor. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression. {ECO:0000250|UniProtKB:P04150, ECO:0000250|UniProtKB:P06537}.
uniprot
proteins
mass_dalton
87556
uniprot
proteins
mutagenesis
MUTAGEN 1; /note="M->T: Abolishes expression of A-type isoforms."; /evidence="ECO:0000269|PubMed:11435610"; MUTAGEN 28; /note="M->T: Abolishes expression of B-type isoforms."; /evidence="ECO:0000269|PubMed:11435610"; MUTAGEN 297; /note="K->R: Enhances transcriptional activity; when associated with R-313."; /evidence="ECO:0000269|PubMed:23508108"; MUTAGEN 313; /note="K->R: Enhances transcriptional activity; when associated with R-297."; /evidence="ECO:0000269|PubMed:23508108"; MUTAGEN 481; /note="D->R: Disrupts dimerization and decreases transcription transactivation."; /evidence="ECO:0000269|PubMed:8618925"; MUTAGEN 488; /note="R->Q: Loss of chromatin specific function and reduces chromatin remodeling. Abolishes interaction with SMARD1."; /evidence="ECO:0000269|PubMed:12917342"; MUTAGEN 500; /note="C->Y: Abolishes interaction with POU2F2."; /evidence="ECO:0000269|PubMed:10480874"; MUTAGEN 501; /note="L->P: Abrogates DNA-binding and transcription transactivation. Abolishes interaction with POU2F1 and POU2F2."; /evidence="ECO:0000269|PubMed:10480874, ECO:0000269|PubMed:11278286"; MUTAGEN 656; /note="C->S: Strongly increases affinity for dexamethasone."; /evidence="ECO:0000269|PubMed:1939229"; MUTAGEN 721; /note="K->R: Abolishes the stimulatory effect of RWDD3 on its transcriptional activity. Diminishes NCOA2 coactivator activity."; /evidence="ECO:0000269|PubMed:23508108"; MUTAGEN 773; /note="E->A: Abolishes interaction with NCOA1 and reduces transcription transactivation; when associated with S-656."; /evidence="ECO:0000269|PubMed:12118039
uniprot
proteins
post_translational_modification
PTM: Acetylation by CLOCK reduces its binding to glucocorticoid response elements and its transcriptional activity. {ECO:0000250}.; PTM: Increased proteasome-mediated degradation in response to glucocorticoids. {ECO:0000250|UniProtKB:P04150}.; PTM: Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoids. The Ser-224, Ser-246 and Ser-424-phosphorylated forms are mainly cytoplasmic, and the Ser-232-phosphorylated form is nuclear. Phosphorylation at Ser-232 increases transcriptional activity. Phosphorylation at Ser-224, Ser-246 and Ser-424 decreases signaling capacity. Phosphorylation at Ser-424 may protect from glucocorticoid-induced apoptosis. Phosphorylation at Ser-224 and Ser-232 is not required in regulation of chromosome segregation. May be dephosphorylated by PPP5C, attenuates NR3C1 action. {ECO:0000250|UniProtKB:P04150, ECO:0000250|UniProtKB:P06537}.; PTM: Sumoylation at Lys-297 and Lys-313 negatively regulates its transcriptional activity. Sumoylation at Lys-721 positively regulates its transcriptional activity in the presence of RWDD3. Sumoylation at Lys-297 and Lys-313 is dispensable whereas sumoylation at Lys-721 is critical for the stimulatory effect of RWDD3 on its transcriptional activity. Heat shock increases sumoylation in a RWDD3-dependent manner. {ECO:0000269|PubMed:23508108}.; PTM: Ubiquitinated by UBR5, leading to its degradation: UBR5 specifically recognizes and binds ligand-bound NR3C1 when it is not associated with coactivators (NCOAs) (By similarity). In presence of NCOAs, the UBR5-degron is not accessible, preventing its ubiquitination and degradation (By similarity). {ECO:0000250|UniProtKB:P06537}.
uniprot
proteins
protein_family
NR3 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
10364267
uniprot
proteins
pubmed
10480874
uniprot
proteins
pubmed
10866662
uniprot
proteins
pubmed
11278286
uniprot
proteins
pubmed
11435610
uniprot
proteins
pubmed
12118039
uniprot
proteins
pubmed
12917342
uniprot
proteins
pubmed
15220929
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
1751485
uniprot
proteins
pubmed
1865905
uniprot
proteins
pubmed
1936288
uniprot
proteins
pubmed
1939229
uniprot
proteins
pubmed
2115209
uniprot
proteins
pubmed
21730050
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23508108
uniprot
proteins
pubmed
3191912
uniprot
proteins
pubmed
3216865
uniprot
proteins
pubmed
3684608
uniprot
proteins
pubmed
3755378
uniprot
proteins
pubmed
8191545
uniprot
proteins
pubmed
8257681
uniprot
proteins
pubmed
8450530
uniprot
proteins
pubmed
8493115
uniprot
proteins
pubmed
8618925
uniprot
proteins
pubmed
9111344
uniprot
proteins
pubmed
9603939
uniprot
proteins
sequence_length
795
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform A]: Cytoplasm {ECO:0000250|UniProtKB:P04150}. Nucleus {ECO:0000250|UniProtKB:P04150}. Mitochondrion {ECO:0000269|PubMed:21730050}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:P04150}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P04150}. Chromosome {ECO:0000250|UniProtKB:P06537}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:P06537}. Note=After ligand activation, translocates from the cytoplasm to the nucleus (By similarity). The hormone-occupied receptor undergoes rapid exchange between chromatin and the nucleoplasmic compartment. In the presence of NR1D1 shows a time-dependent subcellular localization, localizing to the cytoplasm at ZT8 and to the nucleus at ZT20. Lacks this diurnal pattern of localization in the absence of NR1D1, localizing to both nucleus and the cytoplasm at ZT8 and ZT20. Upon dexamethasone binding associates with the glucocorticoid response elements of target genes (By similarity). {ECO:0000250|UniProtKB:P04150, ECO:0000250|UniProtKB:P06537}.
uniprot
proteins