Acp2
entrez
11432
canonical
uniprot
P24638
canonical
ensembl
ENSMUSG00000002103
resolver
ensp
ENSMUSP00000002172
resolver
ensp
ENSMUSP00000159053
resolver
ensp
ENSMUSP00000159089
resolver
enst
ENSMUST00000002172
resolver
enst
ENSMUST00000238832
resolver
enst
ENSMUST00000239169
resolver
genesymbol
Acp2
resolver
uniprot
A0A5F8MPS7
resolver
uniprot
Q3UZN1
resolver
uniprot
Q8QZT5
resolver
uniprot_entry
A0A5F8MPS7_MOUSE
resolver
uniprot_entry
PPAL_MOUSE
resolver
uniprot_entry
Q3UZN1_MOUSE
resolver
uniprot_sec
Q8QZT5
resolver
activity_regulation
ACTIVITY REGULATION: Phosphatase activity is inhibited by L(+)-tartrate. {ECO:0000250|UniProtKB:P11117}.
uniprot
proteins
amino_acid_sequence
MAGRQTGWSQAALLQFLLGMCLTVMPPIQARSLRFVTLLYRHGDRSPVKTYPKDPYQEEKWPQGFGQLTKEGMLQHWELGQALRQRYHGFLNTSYHRQEVYVRSTDFDRTLMSAEANLAGLFPPNEVQHFNPNISWQPIPVHTVPITEDRLLKFPLGPCPRYEQLQNETRQTPEYQNRSIQNAQFLNMVANETGLTNVTLETIWNVYDTLFCEQTHGLLLPPWASPQTVQRLSQLKDFSFLFLFGIHEQVQKARLQGGVLLAQILKNLTLMATTSQFPKLLVYSAHDTTLVALQMALNVYNGKQAPYASCHIFELYQEDNGNFSVEMYFRNDSKKAPWPLILPGCPHRCPLQDFLRLTEPVIPKDWQKECQLANDTADTEVIVALAVCGSILFLLIVLLLTILFRMQAQPPGYHHVADREDHA
uniprot
proteins
ec_number
3.1.3.2
uniprot
proteins
function
FUNCTION: Lysosomal acid phosphatase that catalyzes the hydrolysis of orthophosphoric monoesters to alcohols and phosphate under acidic conditions (PubMed:15503243). May contribute to the removal of mannose-6-phosphate (Man6P) from lysosomal proteins after their delivery to lysosomes, acting in concert with ACP5 (PubMed:22158965). {ECO:0000269|PubMed:15503243, ECO:0000269|PubMed:22158965}.
uniprot
proteins
mass_dalton
48509
uniprot
proteins
post_translational_modification
PTM: The membrane-bound form is converted to the soluble form by sequential proteolytic processing. First, the C-terminal cytoplasmic tail is removed. Cleavage by a lysosomal protease releases the soluble form in the lysosome lumen (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Histidine acid phosphatase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15503243
uniprot
proteins
pubmed
2059337
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22158965
uniprot
proteins
sequence_length
423
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:P11117}; Single-pass membrane protein {ECO:0000255}; Lumenal side {ECO:0000250|UniProtKB:P11117}. Lysosome lumen {ECO:0000250|UniProtKB:P11117}. Note=The soluble form arises by proteolytic processing of the membrane-bound form. {ECO:0000250|UniProtKB:P11117}.
uniprot
proteins
transmembrane_region
TRANSMEM 382..402; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins