Asap1
entrez
314961
canonical
uniprot
Q1AAU6
canonical
ensembl
ENSRNOG00000058733
resolver
ensp
ENSRNOP00000071134
resolver
ensp
ENSRNOP00000072909
resolver
ensp
ENSRNOP00000084328
resolver
genesymbol
Asap1
resolver
genesymbol_syn
Ddef1
resolver
uniprot
Q1AAU4
resolver
uniprot
Q1AAU5
resolver
uniprot_entry
ASAP1_RAT
resolver
uniprot_sec
Q1AAU4
resolver
uniprot_sec
Q1AAU5
resolver
activity_regulation
ACTIVITY REGULATION: Activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYEMKFTKIEKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLDPKEVGGLYVPSRANSDSQSRQGGYSMHQLQGNKEYGSEKKGFLLKKSDGIRKVWQRRKCAVKNGILTISHATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSTGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTCASSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTSVGNTVLHYCSMYGKPECLKLLLRSKPTVDIVNQNGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQDEMDESDDDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTSTDLPTSPTSEAPPLPPRNAGKGPTGPPSTLPLGTQTSSGSSTLSKKRSPPPPPGHKRTLSDPPSPLPHGPPNKGAIPWGNDVGPSSSSKTANKFEGLSQQASTSSAKTALGPRVLPKLPQKVALRKTETSHHLSLDRANIPPETFQKSSQLSELPQKPPLGDLPPKPMELAPKPQIGELPPKPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQASDLSAKVQPPSEVTQRSHTGDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD
uniprot
proteins
function
FUNCTION: Possesses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Part of the ciliary targeting complex containing Rab11, ASAP1, Rabin8/RAB3IP, RAB11FIP3 and ARF4, which direct preciliary vesicle trafficking to mother centriole and ciliogenesis initiation (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q9ULH1}.
uniprot
proteins
mass_dalton
127088
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues by SRC. {ECO:0000250}.
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
1144
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Membrane. Golgi apparatus {ECO:0000250|UniProtKB:Q9ULH1}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q9ULH1}. Note=Predominantly cytoplasmic. Partially membrane-associated (By similarity). {ECO:0000250}.
uniprot
proteins