Eif2b5
entrez
224045
canonical
uniprot
Q8CHW4
canonical
ensembl
ENSMUSG00000003235
resolver
ensp
ENSMUSP00000003320
resolver
ensp
ENSMUSP00000165973
resolver
ensp
ENSMUSP00000165979
resolver
ensp
ENSMUSP00000165985
resolver
enst
ENSMUST00000003320
resolver
genesymbol
Eif2b5
resolver
uniprot
Q3TU39
resolver
uniprot_entry
EI2BE_MOUSE
resolver
uniprot_sec
Q3TU39
resolver
activity_regulation
ACTIVITY REGULATION: Activated by the chemical integrated stress response (ISR) inhibitor ISRIB which stimulates guanine nucleotide exchange factor activity for both phosphorylated and unphosphorylated eIF2. {ECO:0000250|UniProtKB:Q13144}.
uniprot
proteins
amino_acid_sequence
MAATAAVPGAAAGRASKRGGGGSGGGGTQGAEEEPPPPLQAVLVADSFNRRFFPISKDQPRVLLPLANVALIDYTLEFLTATGVQETFVFCCWKAAQIKEHLQKSKWCHPTSPNVVRIITSELYRSLGDVLRDVDAKALVRSDFLLIYGDVISNINICRALEEHRLRRKLEKNVSVMTMVFKESSPSHPTRCHEDNVVMAVDSATNRVLHFQKTQGLRRFSFPLSLFQGSGDGVEIRYDLLDCHISICSPQVAQLFTDNFDYQTRDDFVRGILMNEEVLGNQIHLHVTTREYGARVSNLHMYSAVCADVIRRWVYPLTPEVNFTDSTTQSYTHSRHNIYRGPEVSLGHGSVLEENVLLGAGTVIGSNCSITNSVIGPNCHIGDNVVLDQAYLWQGVRVAAGAQIHQSLLCDRAEVKERVKLKPYCVLTSQVVVGPDITLPEGSVISLHPPDAEEDEDDGQFSDDSGADQEKEKVKLKGYNPAEVGLEGQGYLWKAEGVNSKEDEELRQSLWGLMIKTEEESETESEGSVDPEELDSRAGSPQLDDIRVFQNEVLGTLQRGREENISCENLVLEINSLKHAYNISLKEVMQVLTLVVLEFPLQQVDGLLDPNRYCALLLPLLKAWSPVLRNYIKRAADHLEALAAIEDFFLEHETLVTSMAKVLMAFYQLEILAEETILSWFSQRDTTDEGQQLRKNQQLQRFIQWLREAEEESSEDD
uniprot
proteins
function
FUNCTION: Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on eukaryotic initiation factor 2 (eIF2) gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed. {ECO:0000250|UniProtKB:Q13144}.
uniprot
proteins
mass_dalton
80086
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-540 by DYRK2; this is required for subsequent phosphorylation by GSK3B. Phosphorylated on serine and threonine residues by GSK3B; phosphorylation inhibits its function (By similarity). {ECO:0000250}.; PTM: Polyubiquitinated, probably by NEDD4. {ECO:0000250}.
uniprot
proteins
protein_family
EIF-2B gamma/epsilon subunits family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
717
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P56287}.
uniprot
proteins