Elp5
entrez
54351
canonical
uniprot
Q99L85
canonical
ensembl
ENSMUSG00000018565
resolver
ensp
ENSMUSP00000104235
resolver
ensp
ENSMUSP00000165749
resolver
enst
ENSMUST00000108594
resolver
genesymbol
Elp5
resolver
genesymbol_syn
Derp6
resolver
genesymbol_syn
Rai12
resolver
uniprot
O08973
resolver
uniprot
Q9CUX2
resolver
uniprot_entry
ELP5_MOUSE
resolver
uniprot_sec
O08973
resolver
uniprot_sec
Q9CUX2
resolver
amino_acid_sequence
MLDSLLAIGGLVLLRDSVEWEGRSLLKALIKKSALRGEQVHVLGCEVSEEEFREGFDSDVNSRLVYHDLFRDPLNWSKPGEAVPEGPLKALRSMCKRTDHGSVTIALDSLSWLLCHIPCVTLCQALHALSQQNGDPGDNSLVEQVRVLGLLHEELHGPGSMGALNTLAHTEVTLSGKVDQTSASILCRRPQQRATYQTWWFSVLPDFSLTLHEGLPLRSELHPDHHTTQVDPTAHLTFNLHLSKKEREARDSLTLPFQFSSEKQKALLHPVPSRTTGHIFYEPDAFDDVDPEDPDDDLDI
uniprot
proteins
function
FUNCTION: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Involved in cell migration (PubMed:22854966). {ECO:0000250|UniProtKB:Q8TE02, ECO:0000269|PubMed:22854966}.
uniprot
proteins
mass_dalton
33498
uniprot
proteins
pathway_participation
PATHWAY: tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. {ECO:0000250|UniProtKB:Q8TE02}.
uniprot
proteins
post_translational_modification
PTM: Tyrosine-phosphorylated. {ECO:0000250|UniProtKB:Q8TE02}.
uniprot
proteins
protein_family
ELP5 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22854966
uniprot
proteins
pubmed
30097576
uniprot
proteins
pubmed
9371513
uniprot
proteins
sequence_length
300
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8TE02}. Cytoplasm {ECO:0000250|UniProtKB:Q8TE02}.
uniprot
proteins