CHMP1B
entrez
57132
canonical
uniprot
Q7LBR1
canonical
ensembl
ENSG00000255112
resolver
ensp
ENSP00000432279
resolver
enst
ENST00000526991
resolver
genesymbol
CHMP1B
resolver
genesymbol_syn
C18orf2
resolver
hgnc
HGNC:24287
resolver
uniprot
Q96E89
resolver
uniprot
Q9HD41
resolver
uniprot_entry
CHM1B_HUMAN
resolver
uniprot_sec
Q96E89
resolver
uniprot_sec
Q9HD41
resolver
amino_acid_sequence
MSNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVARIHAENAIRQKNQAVNFLRMSARVDAVAARVQTAVTMGKVTKSMAGVVKSMDATLKTMNLEKISALMDKFEHQFETLDVQTQQMEDTMSSTTTLTTPQNQVDMLLQEMADEAGLDLNMELPQGQTGSVGTSVASAEQDELSQRLARLRDQV
uniprot
proteins
function
FUNCTION: Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B and SPAST to the midbody of dividing cells. Involved in HIV-1 p6- and p9-dependent virus release. {ECO:0000269|PubMed:14519844, ECO:0000269|PubMed:19129479}.
uniprot
proteins
mass_dalton
22109
uniprot
proteins
mutagenesis
MUTAGEN 158..159; /note="DE->AA: Diminishes interaction with VPS4B."; /evidence="ECO:0000269|PubMed:18385515"; MUTAGEN 178; /note="T->R: Abolishes interaction with SPAST and no effect on interaction with VPS4A; when associated with R-181 and R-184."; /evidence="ECO:0000269|PubMed:18997780"; MUTAGEN 181; /note="A->R: Abolishes interaction with SPAScT and no effect on interaction with VPS4A; when associated with R-178 and R-184."; /evidence="ECO:0000269|PubMed:18997780"; MUTAGEN 184; /note="E->A: Decreases interaction with SPAST."; /evidence="ECO:0000269|PubMed:18997780"; MUTAGEN 184; /note="E->R: Abolishes interaction with SPAST and no effect on interaction with VPS4A; when associated with R-178 and R-181."; /evidence="ECO:0000269|PubMed:18997780"; MUTAGEN 188; /note="L->A: Abolishes interaction with SPAST and VPS4A; when associated with A-192."; /evidence="ECO:0000269|PubMed:18997780"; MUTAGEN 192; /note="L->A: Abolishes interaction with SPAST and VPS4A; when associated with A-188."; /evidence="ECO:0000269|PubMed:17928862, ECO:0000269|PubMed:18997780"; MUTAGEN 192; /note="L->A: Abolishes interaction with VPS4B."; /evidence="ECO:0000269|PubMed:17928862, ECO:0000269|PubMed:18997780"; MUTAGEN 195; /note="L->A: Abolishes interaction with VPS4B."; /evidence="ECO:0000269|PubMed:17928862
uniprot
proteins
protein_family
SNF7 family
uniprot
proteins
pubmed
11474171
uniprot
proteins
pubmed
11559747
uniprot
proteins
pubmed
14505570
uniprot
proteins
pubmed
14519844
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15537668
uniprot
proteins
pubmed
16174732
uniprot
proteins
pubmed
16730941
uniprot
proteins
pubmed
17928862
uniprot
proteins
pubmed
18385515
uniprot
proteins
pubmed
18997780
uniprot
proteins
pubmed
19129479
uniprot
proteins
pubmed
19129480
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21543490
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
199
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol. Endosome. Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Localizes to the midbody of dividing cells, colocalizing with CEP55 and CHMP5. Localized at the periphery of the Fleming body.
uniprot
proteins