Slc26a2
entrez
13521
canonical
uniprot
Q62273
canonical
ensembl
ENSMUSG00000034320
resolver
ensp
ENSMUSP00000119447
resolver
enst
ENSMUST00000146409
resolver
genesymbol
Slc26a2
resolver
genesymbol_syn
Dtd
resolver
genesymbol_syn
Dtdst
resolver
uniprot
Q543D6
resolver
uniprot
Q8R2L9
resolver
uniprot_entry
S26A2_MOUSE
resolver
uniprot_sec
Q543D6
resolver
uniprot_sec
Q8R2L9
resolver
amino_acid_sequence
MSSENKEQHDLSPRDLPEEAFGFPSELPLETQRRSGTDLRQSETGHGRRAFRRIHMELREKPDTDIKQFVIRELQKSCQCSAAKVRDGAFDFFPVLRWLPKYDLKKNILGDVMSGLIVGILLVPQSIAYSLLAGQEPIYGLYTSFFASIIYFLFGTSRHISVGIFGILCLMIGEVVDRELHKACPDTDATSSSIAVFSSGCVVVNHTLDGLCDKSCYAIKIGSTVTFMAGVYQVAMGFFQVGFVSVYLSDALLSGFVTGASFTILTSQAKYLLGLSLPRSHGVGSVITTWIHIFRNIRNTNICDLITSLLCLLVLVPSKELNEHFKDKLKAPIPVELIVVVAATLASHFGKLNGNYNSSIAGHIPTGFMPPKAPDWSLIPNVAVDAIAISIIGFAITVSLSEMFAKKHGYTVKANQEMYAIGFCNIIPSFFHCITTSAALAKTLVKESTGCQTQLSAIVTALVLLLVLLVIAPLFYSLQKCVLGVITIVNLRGALLKFRDLPKMWRLSRMDTVIWFVTMLSSALLSTEIGLLVGVCFSMFCVILRTQKPKNSLLGLEEESETFESISTYKNLRSKSGIKVFRFIAPLYYINKECFKSALYKKALNPVLVKAAWKKAAKRKLKEEMVTFRGDPDEVSMQLSHDPLEVHTIVIDCSAIQFLDTAGIHTLKEVRRDYEAVGIQVLLAQCNPSVRDSLARGEYCKKEEETLLFYSLSEAVAFAEDSQNQKGVCVVNGLSLSGD
uniprot
proteins
function
FUNCTION: Sulfate transporter which mediates sulfate uptake into chondrocytes in order to maintain adequate sulfation of proteoglycans which is needed for cartilage development (PubMed:24302720). Mediates electroneutral anion exchange of sulfate ions for oxalate ions, sulfate and oxalate ions for chloride and/or hydroxyl ions and chloride ions for bromide, iodide and nitrate ions (PubMed:20219950, PubMed:22190686, PubMed:24302720). The coupling of sulfate transport to both hydroxyl and chloride ions likely serves to ensure transport at both acidic pH when most sulfate uptake is mediated by sulfate-hydroxide exchange and alkaline pH when most sulfate uptake is mediated by sulfate-chloride exchange (PubMed:22190686). Essential for chondrocyte proliferation, differentiation and cell size expansion (PubMed:24302720). {ECO:0000269|PubMed:20219950, ECO:0000269|PubMed:22190686, ECO:0000269|PubMed:24302720}.
uniprot
proteins
mass_dalton
81604
uniprot
proteins
mutagenesis
MUTAGEN 368; /note="F->A: Reduced sulfate-chloride exchange activity."; /evidence="ECO:0000269|PubMed:22190686"; MUTAGEN 417; /note="E->A,K: Loss of sulfate-chloride exchange activity."; /evidence="ECO:0000269|PubMed:22190686
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:P50443}.
uniprot
proteins
protein_family
SLC26A/SulP transporter (TC 2.A.53) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20219950
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22190686
uniprot
proteins
pubmed
24302720
uniprot
proteins
pubmed
9370300
uniprot
proteins
sequence_length
739
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P50443}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:O70531}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 112..132; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 137..157; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 227..247; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 255..275; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 378..398; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 420..440; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 455..475; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 524..544; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins