Thoc6
entrez
79227
canonical
uniprot
Q6AY87
canonical
ensembl
ENSRNOG00000003497
resolver
ensembl
ENSRNOG00055026587
resolver
ensembl
ENSRNOG00060007876
resolver
ensembl
ENSRNOG00065009749
resolver
ensp
ENSRNOP00000004672
resolver
ensp
ENSRNOP00055037902
resolver
ensp
ENSRNOP00060010030
resolver
ensp
ENSRNOP00065011893
resolver
enst
ENSRNOT00000004672
resolver
enst
ENSRNOT00055046176
resolver
enst
ENSRNOT00060013219
resolver
enst
ENSRNOT00065015725
resolver
genesymbol
Thoc6
resolver
genesymbol_syn
Pdrp
resolver
genesymbol_syn
wdr58
resolver
uniprot_entry
THOC6_RAT
resolver
amino_acid_sequence
MEHATPLAVPLGQAEVFQALQRLHMTIFSQSVSPCGKFLAAGNNYGQIAIFSLSAALSSEAKEESKKPMVTFHAHDGPVYSMVSTDRHLLSAGDGEVKGWLWAEILKKGCKELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHTMDLETGTFTRALRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRIAKEVQTIEVYKHEECSRPHNGRWIGCLATDSDWMVCGGGPALTLWHLRSSTPTTVFPIRAPQKHVTFYQDLILSAGQGCCVNHWQLSGELKAQVPGSSPGLLSLSLNQQPAAPECKVLTASGNSCRVDVFTNLGYRAFSLSF
uniprot
proteins
function
FUNCTION: Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. Plays a key structural role in the oligomerization of the THO-DDX39B complex. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Plays a role in apoptosis negative control involved in brain development. {ECO:0000250|UniProtKB:Q86W42}.
uniprot
proteins
mass_dalton
37423
uniprot
proteins
protein_family
WD repeat THOC6 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
341
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}.
uniprot
proteins