Metrnl
entrez
316842
canonical
uniprot
Q5RJL6
canonical
ensembl
ENSRNOG00000046202
resolver
ensembl
ENSRNOG00055029758
resolver
ensembl
ENSRNOG00060008970
resolver
ensembl
ENSRNOG00065004825
resolver
ensp
ENSRNOP00000066593
resolver
ensp
ENSRNOP00055042492
resolver
ensp
ENSRNOP00060011677
resolver
ensp
ENSRNOP00065004810
resolver
enst
ENSRNOT00000072190
resolver
enst
ENSRNOT00055051548
resolver
enst
ENSRNOT00060015052
resolver
enst
ENSRNOT00065006997
resolver
genesymbol
Metrnl
resolver
uniprot_entry
METRL_RAT
resolver
amino_acid_sequence
MRGVVWAARRRAGQQWPRSPGPGPGPPPPPPLLLLLLLLLGGASAQYSSDLCSWKGSGLTREAHSKEVEQVYLRCSAGSVEWMYPTGALIVNLRPNTFSPAQNLTVCIKPFRDSSGANIYLEKTGELRLLVRDVRGEPGQVQCFSLEQGGLFVEATPQQDISRRTTGFQYELMSGQRGLDLHVLSAPCRPCSDTEVLLAICTSDFVVRGFIEDVTHVPEQQVSVIHLRVSRLHRQKSRVFQPAPEDSGHWLGHVTTLLQCGVRPGHGEFLFTGHVHFGEAQLGCAPRFSDFQKMYRKAEERGINPCEINME
uniprot
proteins
function
FUNCTION: Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
34468
uniprot
proteins
protein_family
Meteorin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24393292
uniprot
proteins
sequence_length
311
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
uniprot
proteins