Stk39
entrez
54348
canonical
uniprot
O88506
canonical
ensembl
ENSRNOG00000024808
resolver
ensembl
ENSRNOG00055023094
resolver
ensembl
ENSRNOG00060002791
resolver
ensembl
ENSRNOG00065016275
resolver
ensp
ENSRNOP00000034162
resolver
ensp
ENSRNOP00000089326
resolver
ensp
ENSRNOP00055032258
resolver
ensp
ENSRNOP00060003190
resolver
ensp
ENSRNOP00065021312
resolver
enst
ENSRNOT00000037133
resolver
enst
ENSRNOT00000098784
resolver
enst
ENSRNOT00055039721
resolver
enst
ENSRNOT00060004496
resolver
enst
ENSRNOT00065027111
resolver
genesymbol
Stk39
resolver
genesymbol_syn
Pask
resolver
genesymbol_syn
Spak
resolver
uniprot
A0A8L2QHT8
resolver
uniprot
O70541
resolver
uniprot_entry
A0A8L2QHT8_RAT
resolver
uniprot_entry
STK39_RAT
resolver
uniprot_sec
O70541
resolver
activity_regulation
ACTIVITY REGULATION: Activated following phosphorylation at Thr-240 by WNK kinases (WNK1, WNK2, WNK3 or WNK4). {ECO:0000269|PubMed:16083423, ECO:0000269|PubMed:16263722, ECO:0000269|PubMed:22544747}.
uniprot
proteins
amino_acid_sequence
MAEPSGSPVHVQLPQQAAPVTAAAAAPAAATSAPAPAPAPAAPAAPAPAPAAAPAPAPAAQAVGWPICRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVVTYYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQIHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCLQKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQRAKKVRRVPGSSGHLHKTEDGDWEWSDDEMDEKSEEGKAAASQEKSRRVKEENPEISVNAGGIPEQIQSLSVHDSQGQPNANEDYREGPCAVNLVLRLRNSRKELNDIRFEFTPGRDTADGVSQELFSAGLVDGHDVVIVAANLQKIVDDPKALKTLTFKLASGCDGAEIPDEVKLIGFAQLSVS
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Effector serine/threonine-protein kinase component of the WNK-SPAK/OSR1 kinase cascade, which is involved in various processes, such as ion transport, response to hypertonic stress and blood pressure (PubMed:22544747). Specifically recognizes and binds proteins with a RFXV motif (By similarity). Acts downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4): following activation by WNK kinases, catalyzes phosphorylation of ion cotransporters, such as SLC12A1/NKCC2, SLC12A2/NKCC1, SLC12A3/NCC, SLC12A5/KCC2 or SLC12A6/KCC3, regulating their activity (PubMed:22544747). Mediates regulatory volume increase in response to hyperosmotic stress by catalyzing phosphorylation of ion cotransporters SLC12A1/NKCC2, SLC12A2/NKCC1 and SLC12A6/KCC3 downstream of WNK1 and WNK3 kinases (By similarity). Phosphorylation of Na-K-Cl cotransporters SLC12A2/NKCC1 and SLC12A2/NKCC1 promote their activation and ion influx; simultaneously, phosphorylation of K-Cl cotransporters SLC12A5/KCC2 and SLC12A6/KCC3 inhibit their activity, blocking ion efflux (PubMed:22544747). Acts as a regulator of NaCl reabsorption in the distal nephron by mediating phosphorylation and activation of the thiazide-sensitive Na-Cl cotransporter SLC12A3/NCC in distal convoluted tubule cells of kidney downstream of WNK4 (By similarity). Mediates the inhibition of SLC4A4, SLC26A6 as well as CFTR activities. Phosphorylates RELT (By similarity). {ECO:0000250|UniProtKB:Q9UEW8, ECO:0000250|UniProtKB:Q9Z1W9, ECO:0000269|PubMed:22544747}.
uniprot
proteins
mass_dalton
60051
uniprot
proteins
mutagenesis
MUTAGEN 212; /note="D->A: Abolished serine/threonine-protein kinase activity."; /evidence="ECO:0000269|PubMed:16083423"; MUTAGEN 380; /note="S->A: Decreased phosphorylation by WNK1."; /evidence="ECO:0000269|PubMed:16263722
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-240 by WNK kinases (WNK1, WNK2, WNK3 or WNK4) is required for activation (PubMed:16083423, PubMed:16263722). Autophosphorylation at Thr-240 positively regulates its activity (By similarity). Phosphorylated at Ser-318 by PRKCQ (By similarity). {ECO:0000250|UniProtKB:Q9UEW8, ECO:0000269|PubMed:16083423, ECO:0000269|PubMed:16263722}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
protein_family
STE20 subfamily
uniprot
proteins
pubmed
10980603
uniprot
proteins
pubmed
10990492
uniprot
proteins
pubmed
16083423
uniprot
proteins
pubmed
16263722
uniprot
proteins
pubmed
22544747
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9675032
uniprot
proteins
sequence_length
553
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}. Note=Nucleus when caspase-cleaved. {ECO:0000305}.
uniprot
proteins