Fcmr
entrez
548326
canonical
uniprot
Q5M871
canonical
ensembl
ENSRNOG00000004441
resolver
ensp
ENSRNOP00000036615
resolver
genesymbol
Fcmr
resolver
genesymbol_syn
Faim3
resolver
genesymbol_syn
Toso
resolver
uniprot_entry
FCMR_RAT
resolver
amino_acid_sequence
MNLWLWLLYFLPVSGTLKVLPEVRLEVELGGSVFIECPLPQTHVRMYLCRQMTNPAICATVVSNIFVKKEYKRRVTLKPSLNKKLFLVEMTQLTKDDEGIYACGVGTNTDLGKTQKVTLNVRNEFPEYPEPFWDDEPTSEPSPRWWLHRYPEELPWLKMGEHASPSGFIDKVTTLSPKTEAPPVHQPSTNTSVSRHPRVYGASSETPTKPSALLPATTAFKTSARQASRLLEASYSHHTRLHGERTPHYGSQYGREDRGLHISIPEFHILIPTFLGFLLLVLLGLVVKRAIQRRRAFSRRVGRMARRMRGRGPSRQIPTQRRDAPQRPRSQNNVYSACPRRAREPDNVGSAEALLLNAPASAPPALPLVIETSWPHTPSLKMSCEYVSLGHQPAVNVEDQDSNDYINIPGLPHLPSKPPGPRPSRQ
uniprot
proteins
function
FUNCTION: High-affinity Fc receptor for immunoglobulin M (IgM), both secreted and membrane-bound IgM (By similarity). Primarily regulates IgM transport and homeostasis. In lymphoid cells, enables exocytosis of membrane-bound IgM on the plasma membrane as well as endocytosis of IgM-antigen complexes toward lysosomes for degradation. In mucosal epithelium, mediates retrotranscytosis of antigen-IgM complexes across mucosal M cells toward antigen-presenting cells in mucosal lymphoid tissues (By similarity). Triggers costimulatory signaling and mediates most of IgM effector functions involved in B cell development and primary immune response to infection. Likely limits tonic IgM BCR signaling to self-antigens for proper negative selection of autoreactive B cells in the bone marrow and for the maintenance of regulatory B cell pool in peripheral lymphoid organs. Mediates antibody responses to T cell-dependent and T cell-independent antigens and promotes induction of an efficient neutralizing IgG response. Engages in cross-talk with antigen-receptor signaling via the non-canonical NF-kappa-B, MAP kinases and calcium signaling pathways (By similarity). {ECO:0000250|UniProtKB:O60667}.
uniprot
proteins
mass_dalton
48055
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on both Tyr and Ser residues. {ECO:0000250|UniProtKB:O60667}.; PTM: O-glycosylated. Sialylated. O-linked glycans regulate trafficking to the plasma membrane. {ECO:0000250|UniProtKB:O60667}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641100
uniprot
proteins
sequence_length
426
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O60667}; Single-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:O60667}; Single-pass membrane protein {ECO:0000255}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:O60667}; Single-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:O60667}; Single-pass membrane protein {ECO:0000255}. Note=Continuously recycles between cytoplasmic pool and the plasma membrane to bind as much IgM as possible. {ECO:0000250|UniProtKB:O60667}.
uniprot
proteins
transmembrane_region
TRANSMEM 267..287; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins