TPST2
entrez
8459
canonical
uniprot
O60704
canonical
ensembl
ENSG00000128294
resolver
ensp
ENSP00000339813
resolver
ensp
ENSP00000381180
resolver
ensp
ENSP00000385192
resolver
ensp
ENSP00000400357
resolver
ensp
ENSP00000580469
resolver
ensp
ENSP00000580470
resolver
ensp
ENSP00000580471
resolver
ensp
ENSP00000580472
resolver
ensp
ENSP00000580473
resolver
ensp
ENSP00000580474
resolver
ensp
ENSP00000580475
resolver
ensp
ENSP00000580477
resolver
ensp
ENSP00000580478
resolver
ensp
ENSP00000580480
resolver
ensp
ENSP00000580481
resolver
ensp
ENSP00000580482
resolver
ensp
ENSP00000580483
resolver
ensp
ENSP00000580484
resolver
ensp
ENSP00000580485
resolver
ensp
ENSP00000580486
resolver
ensp
ENSP00000580487
resolver
ensp
ENSP00000580488
resolver
ensp
ENSP00000580489
resolver
ensp
ENSP00000580490
resolver
ensp
ENSP00000580491
resolver
ensp
ENSP00000580492
resolver
ensp
ENSP00000580493
resolver
ensp
ENSP00000580494
resolver
ensp
ENSP00000580495
resolver
ensp
ENSP00000591201
resolver
ensp
ENSP00000591202
resolver
ensp
ENSP00000591203
resolver
ensp
ENSP00000591204
resolver
ensp
ENSP00000591205
resolver
ensp
ENSP00000591206
resolver
ensp
ENSP00000591208
resolver
ensp
ENSP00000591209
resolver
ensp
ENSP00000591210
resolver
ensp
ENSP00000591211
resolver
ensp
ENSP00000611053
resolver
ensp
ENSP00000611054
resolver
ensp
ENSP00000611055
resolver
ensp
ENSP00000611056
resolver
ensp
ENSP00000611057
resolver
ensp
ENSP00000611058
resolver
ensp
ENSP00000611059
resolver
ensp
ENSP00000611060
resolver
ensp
ENSP00000611061
resolver
ensp
ENSP00000611062
resolver
enst
ENST00000338754
resolver
enst
ENST00000398110
resolver
enst
ENST00000403880
resolver
enst
ENST00000454778
resolver
enst
ENST00000910410
resolver
enst
ENST00000910411
resolver
enst
ENST00000910412
resolver
enst
ENST00000910413
resolver
enst
ENST00000910414
resolver
enst
ENST00000910415
resolver
enst
ENST00000910416
resolver
enst
ENST00000910418
resolver
enst
ENST00000910419
resolver
enst
ENST00000910421
resolver
enst
ENST00000910422
resolver
enst
ENST00000910423
resolver
enst
ENST00000910424
resolver
enst
ENST00000910425
resolver
enst
ENST00000910426
resolver
enst
ENST00000910427
resolver
enst
ENST00000910428
resolver
enst
ENST00000910429
resolver
enst
ENST00000910430
resolver
enst
ENST00000910431
resolver
enst
ENST00000910432
resolver
enst
ENST00000910433
resolver
enst
ENST00000910434
resolver
enst
ENST00000910435
resolver
enst
ENST00000910436
resolver
enst
ENST00000921142
resolver
enst
ENST00000921143
resolver
enst
ENST00000921144
resolver
enst
ENST00000921145
resolver
enst
ENST00000921146
resolver
enst
ENST00000921147
resolver
enst
ENST00000921149
resolver
enst
ENST00000921150
resolver
enst
ENST00000921151
resolver
enst
ENST00000921152
resolver
enst
ENST00000940994
resolver
enst
ENST00000940995
resolver
enst
ENST00000940996
resolver
enst
ENST00000940997
resolver
enst
ENST00000940998
resolver
enst
ENST00000940999
resolver
enst
ENST00000941000
resolver
enst
ENST00000941001
resolver
enst
ENST00000941002
resolver
enst
ENST00000941003
resolver
genesymbol
TPST2
resolver
hgnc
HGNC:12021
resolver
uniprot
B3KQA7
resolver
uniprot
Q6FI98
resolver
uniprot
Q9H0V4
resolver
uniprot_entry
TPST2_HUMAN
resolver
uniprot_sec
B3KQA7
resolver
uniprot_sec
Q6FI98
resolver
uniprot_sec
Q9H0V4
resolver
amino_acid_sequence
MRLSVRRVLLAAGCALVLVLAVQLGQQVLECRAVLAGLRSPRGAMRPEQEELVMVGTNHVEYRYGKAMPLIFVGGVPRSGTTLMRAMLDAHPEVRCGEETRIIPRVLAMRQAWSKSGREKLRLDEAGVTDEVLDAAMQAFILEVIAKHGEPARVLCNKDPFTLKSSVYLSRLFPNSKFLLMVRDGRASVHSMITRKVTIAGFDLSSYRDCLTKWNKAIEVMYAQCMEVGKEKCLPVYYEQLVLHPRRSLKLILDFLGIAWSDAVLHHEDLIGKPGGVSLSKIERSTDQVIKPVNLEALSKWTGHIPGDVVRDMAQIAPMLAQLGYDPYANPPNYGNPDPFVINNTQRVLKGDYKTPANLKGYFQVNQNSTSSHLGSS
uniprot
proteins
ec_number
2.8.2.20
uniprot
proteins
function
FUNCTION: Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate. {ECO:0000269|PubMed:9733778}.
uniprot
proteins
mass_dalton
41912
uniprot
proteins
mutagenesis
MUTAGEN 78; /note="R->A: Strongly reduced enzymatic activity."; /evidence="ECO:0000269|PubMed:23481380"; MUTAGEN 99; /note="E->A: Loss of sulfotransferase activity."; /evidence="ECO:0000269|PubMed:23481380"; MUTAGEN 101; /note="R->A: Prevents dimerization and strongly decreases enzyme activity."; /evidence="ECO:0000269|PubMed:23481380"; MUTAGEN 113; /note="W->A: Prevents dimerization and decreases enzyme activity."; /evidence="ECO:0000269|PubMed:23481380"; MUTAGEN 158; /note="K->A: Nearly complete loss of enzymatic activity."; /evidence="ECO:0000269|PubMed:23481380"; MUTAGEN 198; /note="T->A: Slightly decreased sulfotransferase activity."; /evidence="ECO:0000269|PubMed:23481380"; MUTAGEN 285; /note="S->A: Abolishes sulfotransferase activity."; /evidence="ECO:0000269|PubMed:23481380
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:9733778}.
uniprot
proteins
protein_family
Protein sulfotransferase family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
23481380
uniprot
proteins
pubmed
25660941
uniprot
proteins
pubmed
9733778
uniprot
proteins
pubmed
9736702
uniprot
proteins
sequence_length
377
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:25660941}; Single-pass type II membrane protein {ECO:0000269|PubMed:25660941}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..25; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins