CEP85
entrez
64793
canonical
uniprot
Q6P2H3
canonical
ensembl
ENSG00000130695
resolver
ensp
ENSP00000252992
resolver
ensp
ENSP00000417002
resolver
ensp
ENSP00000492362
resolver
ensp
ENSP00000598505
resolver
genesymbol
CEP85
resolver
genesymbol_syn
CCDC21
resolver
hgnc
HGNC:25309
resolver
uniprot
B4DRL1
resolver
uniprot
D3DPK4
resolver
uniprot
F8W7K4
resolver
uniprot
Q5VY68
resolver
uniprot
Q5VY70
resolver
uniprot
Q9H6Q1
resolver
uniprot
Q9H828
resolver
uniprot
Q9UF52
resolver
uniprot_entry
CEP85_HUMAN
resolver
uniprot_sec
B4DRL1
resolver
uniprot_sec
D3DPK4
resolver
uniprot_sec
F8W7K4
resolver
uniprot_sec
Q5VY68
resolver
uniprot_sec
Q5VY70
resolver
uniprot_sec
Q9H6Q1
resolver
uniprot_sec
Q9H828
resolver
uniprot_sec
Q9UF52
resolver
amino_acid_sequence
MAMQEKYPTEGISHVTSPSSDVIQKGSSLGTEWQTPVISEPFRSRFSRCSSVADSGDTAIGTSCSDIAEDFCSSSGSPPFQPIKSHVTIPTAHVMPSTLGTSPAKPNSTPVGPSSSKLPLSGLAESVGMTRNGDLGAMKHSPGLSRDLMYFSGATGENGIEQSWFPAVGHERQEEARKFDIPSMESTLNQSAMMETLYSDPHHRVRFHNPRTSTSKELYRVLPEAKKAPGSGAVFERNGPHSNSSGVLPLGLQPAPGLSKPLPSQVWQPSPDTWHPREQSCELSTCRQQLELIRLQMEQMQLQNGAICHHPAAFGPSLPILEPAQWISILNSNEHLLKEKELLIDKQRKHISQLEQKVRESELQVHSALLGRPAPFGDVCLLRLQELQRENTFLRAQFAQKTEALSREKIDLEKKLSASEVEVQLIRESLKVALQKHSEEVKKQEERVKGRDKHINNLKKKCQKESEQNREKQQRIETLERYLADLPTLEDHQKQSQQLKDSELKSTELQEKVTELESLLEETQAICREKEIQLESLRQREAEFSSAGHSLQDKQSVEETSGEGPEVEMESWQKRYDSLQKIVEKQQQKMDQLRSQVQSLEQEVAQEEGTSQALREEAQRRDSALQQLRTAVKELSVQNQDLIEKNLTLQEHLRQAQPGSPPSPDTAQLALELHQELASCLQDLQAVCSIVTQRAQGHDPNLSLLLGIHSAQHPETQLDLQKPDVIKRKLEEVQQLRRDIEDLRTTMSDRYAQDMGENCVTQ
uniprot
proteins
function
FUNCTION: Acts as a regulator of centriole duplication through a direct interaction with STIL, a key factor involved in the early steps of centriole formation. The CEP85-STIL protein complex acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility (PubMed:29712910, PubMed:32107292). Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity (PubMed:26220856). {ECO:0000269|PubMed:26220856, ECO:0000269|PubMed:29712910, ECO:0000269|PubMed:32107292}.
uniprot
proteins
mass_dalton
85639
uniprot
proteins
mutagenesis
MUTAGEN 640; /note="Q->A: Strongly reduced interaction with STIL. Strongly reduced interaction with STIL; when associated with A-644. Does not affect interaction wit PLKA; when associated with A-644."; /evidence="ECO:0000269|PubMed:29712910, ECO:0000269|PubMed:32107292"; MUTAGEN 644; /note="E->A: Strongly reduced interaction with STIL. Strongly reduced interaction with STIL; when associated with A-640. Does not affect interaction wit PLKA; when associated with A-644."; /evidence="ECO:0000269|PubMed:29712910, ECO:0000269|PubMed:32107292
uniprot
proteins
protein_family
CEP85 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21399614
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26220856
uniprot
proteins
pubmed
26471995
uniprot
proteins
pubmed
29712910
uniprot
proteins
pubmed
32107292
uniprot
proteins
sequence_length
762
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21399614, ECO:0000269|PubMed:26220856}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:21399614, ECO:0000269|PubMed:26220856}. Nucleus, nucleolus {ECO:0000269|PubMed:21399614}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:29712910, ECO:0000269|PubMed:32107292}. Cytoplasm, cell cortex {ECO:0000269|PubMed:32107292}. Note=Localizes to centrosomes and nucleolus in interphase. Upon entry into mitosis, relocates from nucleolus and accumulates at spindle poles (PubMed:21399614). Associated with the pericentriolar material. Localizes to centrosomes at a low level in G1 phase and a slightly increased level in S phase, with gradually elevated levels during G2 phase. The levels at centrosomes further increase at G2/M, reaching a peak at spindle poles at early mitotic stages and remain high until the end of anaphase (PubMed:26220856). Localizes at the leading edge (PubMed:32107292). {ECO:0000269|PubMed:21399614, ECO:0000269|PubMed:26220856, ECO:0000269|PubMed:32107292}.
uniprot
proteins