POFUT2
entrez
23275
canonical
uniprot
Q9Y2G5
canonical
ensembl
ENSG00000186866
resolver
ensp
ENSP00000329682
resolver
ensp
ENSP00000339613
resolver
ensp
ENSP00000478168
resolver
ensp
ENSP00000568254
resolver
ensp
ENSP00000568255
resolver
ensp
ENSP00000568257
resolver
ensp
ENSP00000758901
resolver
enst
ENST00000612472
resolver
genesymbol
POFUT2
resolver
genesymbol_syn
C21orf80
resolver
genesymbol_syn
FUT13
resolver
genesymbol_syn
KIAA0958
resolver
hgnc
HGNC:14683
resolver
uniprot
A0A087WTV8
resolver
uniprot
Q6PJV1
resolver
uniprot
Q7Z4N0
resolver
uniprot
Q8WWU6
resolver
uniprot
Q9BQS4
resolver
uniprot
Q9BQS5
resolver
uniprot
Q9UFY3
resolver
uniprot
S6FW71
resolver
uniprot_entry
A0A087WTV8_HUMAN
resolver
uniprot_entry
OFUT2_HUMAN
resolver
uniprot_entry
S6FW71_HUMAN
resolver
uniprot_sec
Q6PJV1
resolver
uniprot_sec
Q7Z4N0
resolver
uniprot_sec
Q8WWU6
resolver
uniprot_sec
Q9BQS4
resolver
uniprot_sec
Q9BQS5
resolver
uniprot_sec
Q9UFY3
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by EDTA and by Zn(2+). {ECO:0000269|PubMed:22588082}.
uniprot
proteins
amino_acid_sequence
MATLSFVFLLLGAVSWPPASASGQEFWPGQSAADILSGAASRRRYLLYDVNPPEGFNLRRDVYIRIASLLKTLLKTEEWVLVLPPWGRLYHWQSPDIHQVRIPWSEFFDLPSLNKNIPVIEYEQFIAESGGPFIDQVYVLQSYAEGWKEGTWEEKVDERPCIDQLLYSQDKHEYYRGWFWGYEETRGLNVSCLSVQGSASIVAPLLLRNTSARSVMLDRAENLLHDHYGGKEYWDTRRSMVFARHLREVGDEFRSRHLNSTDDADRIPFQEDWMKMKVKLGSALGGPYLGVHLRRKDFIWGHRQDVPSLEGAVRKIRSLMKTHRLDKVFVATDAVRKEYEELKKLLPEMVRFEPTWEELELYKDGGVAIIDQWICAHARFFIGTSVSTFSFRIHEEREILGLDPKTTYNRFCGDQEKACEQPTHWKITY
uniprot
proteins
ec_number
2.4.1.221
uniprot
proteins
function
FUNCTION: GDP-fucose protein O-fucosyltransferase involved in one of the two pathways responsible for protein O-linked fucosylation, a unique post-translational modification of cysteine-knotted proteins that regulates various biological functions. This pathway targets proteins with Thrombospondin type-1 (TSP1) repeats (TSR) in the endoplasmic reticulum. Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively (PubMed:22588082). O-fucosylates members of several protein families including the ADAMTS, the thrombospondin (TSP) and spondin families (Probable) (PubMed:17395588). Required for the proper secretion of ADAMTS family members such as ADAMTSL1 and ADAMTS13 (PubMed:17395588, PubMed:17395589). The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm (By similarity). {ECO:0000250|UniProtKB:Q8VHI3, ECO:0000269|PubMed:17395588, ECO:0000269|PubMed:17395589, ECO:0000269|PubMed:22588082, ECO:0000305|PubMed:11067851, ECO:0000305|PubMed:16464858}.
uniprot
proteins
mass_dalton
49976
uniprot
proteins
mutagenesis
MUTAGEN 54; /note="E->A: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:22588082"; MUTAGEN 92; /note="W->A: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:22588082"; MUTAGEN 152; /note="W->A: Reduces enzyme activity."; /evidence="ECO:0000269|PubMed:22588082"; MUTAGEN 273; /note="W->A: Reduces enzyme activity."; /evidence="ECO:0000269|PubMed:22588082"; MUTAGEN 294; /note="R->A: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:22588082"; MUTAGEN 297; /note="D->A: Reduces enzyme activity."; /evidence="ECO:0000269|PubMed:22588082"; MUTAGEN 395; /note="E->A: No enhanced secretion of ADASMTS13; when associated with A-396."; /evidence="ECO:0000269|PubMed:17395589"; MUTAGEN 396; /note="E->A: Reduces enzyme activity. No enhanced secretion of ADASMTS13; when associated with A-396."; /evidence="ECO:0000269|PubMed:17395589, ECO:0000269|PubMed:22588082
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:16464858, ECO:0000269|PubMed:22588082}.
uniprot
proteins
protein_family
Glycosyltransferase 68 family
uniprot
proteins
pubmed
10231032
uniprot
proteins
pubmed
10830953
uniprot
proteins
pubmed
11067851
uniprot
proteins
pubmed
12966037
uniprot
proteins
pubmed
15233996
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16464858
uniprot
proteins
pubmed
17395588
uniprot
proteins
pubmed
17395589
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
22588082
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
429
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:15233996}. Golgi apparatus {ECO:0000269|PubMed:15233996}. Note=Mainly located in the endoplasmic reticulum. {ECO:0000269|PubMed:15233996}.
uniprot
proteins