NPEPPS
entrez
9520
canonical
uniprot
P55786
canonical
ensembl
ENSG00000141279
resolver
ensp
ENSP00000320324
resolver
ensp
ENSP00000433287
resolver
ensp
ENSP00000503284
resolver
ensp
ENSP00000503738
resolver
ensp
ENSP00000503773
resolver
enst
ENST00000530173
resolver
enst
ENST00000677370
resolver
enst
ENST00000677664
resolver
enst
ENST00000678262
resolver
genesymbol
NPEPPS
resolver
genesymbol_syn
PSA
resolver
hgnc
HGNC:7900
resolver
uniprot
A0A7I2V389
resolver
uniprot
A0A7I2V3W8
resolver
uniprot
B7Z463
resolver
uniprot
B7Z899
resolver
uniprot
E9PLK3
resolver
uniprot
Q6P145
resolver
uniprot
Q9NP16
resolver
uniprot
Q9UEM2
resolver
uniprot_entry
A0A7I2V389_HUMAN
resolver
uniprot_entry
A0A7I2V3W8_HUMAN
resolver
uniprot_entry
B7Z899_HUMAN
resolver
uniprot_entry
E9PLK3_HUMAN
resolver
uniprot_entry
PSA_HUMAN
resolver
uniprot_sec
B7Z463
resolver
uniprot_sec
Q6P145
resolver
uniprot_sec
Q9NP16
resolver
uniprot_sec
Q9UEM2
resolver
activity_regulation
ACTIVITY REGULATION: Strongly inhibited by bestatin, leuhistin, actinonin, amastatin, 1,10-phenanthroline, DFP, PCMBS, Zn(2+), Cd(2+), Co(2+), Cu(2+), Hg(2+), EDTA and puromycin. Not inhibited by PMSF, and only slightly inhibited by leupeptin and aprotinin. Activity is increased by Mg(2+) and Ca(2+). {ECO:0000269|PubMed:10978616, ECO:0000269|PubMed:17154549, ECO:0000269|PubMed:17318184}.
uniprot
proteins
amino_acid_sequence
MWLAAAAPSLARRLLFLGPPPPPLLLLVFSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGDEEIHATGFNYQNEDEKVTLSFPSTLQTGTGTLKIDFVGELNDKMKGFYRSKYTTPSGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWESLENASGKPIAAVMNTWTKQMGFPLIYVEAEQVEDDRLLRLSQKKFCAGGSYVGEDCPQWMVPITISTSEDPNQAKLKILMDKPEMNVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLESLLPGIRDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGILSTLLSHTDFYEEIQEFVKDVFSPIGERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKATLEEARRRFKDHVEGKQILSADLRSPVYLTVLKHGDGTTLDIMLKLHKQADMQEEKNRIERVLGATLLPDLIQKVLTFALSEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELYNRYQGGFLISRLIKLSVEGFAVDKMAGEVKAFFESHPAPSAERTIQQCCENILLNAAWLKRDAESIHQYLLQRKASPPTV
uniprot
proteins
ec_number
3.4.11.14
uniprot
proteins
function
FUNCTION: Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain. {ECO:0000269|PubMed:10978616, ECO:0000269|PubMed:11062501, ECO:0000269|PubMed:17154549, ECO:0000269|PubMed:17318184, ECO:0000269|PubMed:19917696}.
uniprot
proteins
mass_dalton
103276
uniprot
proteins
mutagenesis
MUTAGEN 353; /note="E->A: Reduces catalytic activity by 25,000-fold to 100,000-fold."; /evidence="ECO:0000269|PubMed:12729622"; MUTAGEN 353; /note="E->Q: Reduces catalytic activity by 5,000-fold to 15,000-fold."; /evidence="ECO:0000269|PubMed:12729622"; MUTAGEN 353; /note="E->V: Reduces catalytic activity by 300,000-fold to 500,000-fold."; /evidence="ECO:0000269|PubMed:12729622"; MUTAGEN 438; /note="Y->F: Reduces catalytic activity by 1,000-fold to 2,500-fold."; /evidence="ECO:0000269|PubMed:12729622
uniprot
proteins
protein_family
Peptidase M1 family
uniprot
proteins
pubmed
10329370
uniprot
proteins
pubmed
10978616
uniprot
proteins
pubmed
11062501
uniprot
proteins
pubmed
11435692
uniprot
proteins
pubmed
12729622
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17154549
uniprot
proteins
pubmed
17318184
uniprot
proteins
pubmed
19917696
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9048733
uniprot
proteins
sequence_length
919
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10978616}. Nucleus {ECO:0000305}.
uniprot
proteins