HMGB3
entrez
3149
canonical
uniprot
O15347
canonical
ensembl
ENSG00000029993
resolver
ensp
ENSP00000359393
resolver
ensp
ENSP00000442758
resolver
ensp
ENSP00000524956
resolver
ensp
ENSP00000524957
resolver
ensp
ENSP00000524958
resolver
ensp
ENSP00000524959
resolver
ensp
ENSP00000524960
resolver
ensp
ENSP00000524961
resolver
ensp
ENSP00000588106
resolver
ensp
ENSP00000588107
resolver
ensp
ENSP00000588108
resolver
enst
ENST00000325307
resolver
enst
ENST00000448905
resolver
enst
ENST00000854897
resolver
enst
ENST00000854898
resolver
enst
ENST00000854899
resolver
enst
ENST00000854900
resolver
enst
ENST00000854901
resolver
enst
ENST00000854902
resolver
enst
ENST00000918047
resolver
enst
ENST00000918048
resolver
enst
ENST00000918049
resolver
genesymbol
HMGB3
resolver
genesymbol_syn
HMG2A
resolver
genesymbol_syn
HMG4
resolver
hgnc
HGNC:5004
resolver
uniprot
O95556
resolver
uniprot
Q6NS40
resolver
uniprot_entry
HMGB3_HUMAN
resolver
uniprot_sec
O95556
resolver
uniprot_sec
Q6NS40
resolver
amino_acid_sequence
MAKGDPKKPKGKMSAYAFFVQTCREEHKKKNPEVPVNFAEFSKKCSERWKTMSGKEKSKFDEMAKADKVRYDREMKDYGPAKGGKKKKDPNAPKRPPSGFFLFCSEFRPKIKSTNPGISIGDVAKKLGEMWNNLNDSEKQPYITKAAKLKEKYEKDVADYKSKGKFDGAKGPAKVARKKVEEEDEEEEEEEEEEEEEEDE
uniprot
proteins
disease_involvement
DISEASE: Microphthalmia, syndromic, 13 (MCOPS13) [MIM:300915]: A form of microphthalmia, a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS13 patients exhibit colobomatous microphthalmia with microcephaly, short stature, and psychomotor retardation. {ECO:0000269|PubMed:24993872}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference for non-canonical DNA structures such as single-stranded DNA. Can bend DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor (By similarity). Negatively regulates B-cell and myeloid cell differentiation. In hematopoietic stem cells may regulate the balance between self-renewal and differentiation. Involved in negative regulation of canonical Wnt signaling (By similarity). {ECO:0000250|UniProtKB:O54879, ECO:0000250|UniProtKB:P09429, ECO:0000250|UniProtKB:P40618}.
uniprot
proteins
mass_dalton
22980
uniprot
proteins
post_translational_modification
PTM: Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-104 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities in various cellular compartments: 1- fully reduced HMGB3 (HMGB3C23hC45hC104h), 2- disulfide HMGB3 (HMGB3C23-C45C104h) and 3- sulfonyl HMGB3 (HMGB3C23soC45soC104so). {ECO:0000250|UniProtKB:P09429, ECO:0000305|PubMed:24531895}.
uniprot
proteins
protein_family
HMGB family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
20598277
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24531895
uniprot
proteins
pubmed
24993872
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
9370291
uniprot
proteins
sequence_length
200
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P40618, ECO:0000255|PROSITE-ProRule:PRU00267}. Chromosome {ECO:0000305}. Cytoplasm {ECO:0000250|UniProtKB:O54879}.
uniprot
proteins