Tmem259
entrez
216157
canonical
uniprot
Q8CIV2
canonical
ensembl
ENSMUSG00000013858
resolver
ensp
ENSMUSP00000056792
resolver
ensp
ENSMUSP00000119572
resolver
ensp
ENSMUSP00000347441
resolver
genesymbol
Tmem259
resolver
genesymbol_syn
ORF61
resolver
uniprot
Q68EE1
resolver
uniprot
Q6KAN7
resolver
uniprot
Q7TS84
resolver
uniprot
Q8CIV1
resolver
uniprot
Q99K29
resolver
uniprot_entry
MBRL_MOUSE
resolver
uniprot_sec
Q68EE1
resolver
uniprot_sec
Q6KAN7
resolver
uniprot_sec
Q7TS84
resolver
uniprot_sec
Q8CIV1
resolver
uniprot_sec
Q99K29
resolver
amino_acid_sequence
MSEHAAAPGPGPNGGGGGGAAPVRGPRGPNLNPNPLINVRDRLFHALFFKMAVTYSRLFPPAFRRLFEFFVLLKALFVLFVLAYIHIVFSRSPINCLEHVRDRWPREGVLRVEVRHNSSRAPVILQFCDGGLGGLELEPGGLELEEEELTVEMFTNSSIKFELDIEPKVFKPQSGADALNDSQDFPFPETPAKVWPQDEYIVEYSLEYGFLRLSQATRQRLSIPVMVVTLDPTRDQCFGDRFSRLLLDEFLGYDDILMSSVKGLAENEENKGFLRNVVSGEHYRFVSMWMARTSYLAAFVIMVIFTLSVSMLLRYSHHQIFVFIVDLLQMLEMNMAIAFPAAPLLTVILALVGMEAIMSEFFNDTTTAFYIILTVWLADQYDAICCHTNTSKRHWLRFFYLYHFAFYAYHYRFNGQYSSLALVTSWLFIQHSMIYFFHHYELPAILQQIRIQEMLLQTPPLGPGTPTALPDDLNNNSGSPATPDPSPPLALGPSSSPAPTGGASGPGSLGAGASVSGSDLGWVAETAAIISDASFLSGLSASLLERRPTAPSTPDSSRPDPGVPLEDAPAPAGS
uniprot
proteins
function
FUNCTION: May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against ER stress. {ECO:0000269|PubMed:25977983}.
uniprot
proteins
mass_dalton
63561
uniprot
proteins
protein_family
Membralin family
uniprot
proteins
pubmed
12638133
uniprot
proteins
pubmed
15449545
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25977983
uniprot
proteins
sequence_length
574
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25977983}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 69..89; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 293..313; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 337..357; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 417..437; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins