ACKR4
entrez
51554
canonical
uniprot
Q9NPB9
canonical
ensembl
ENSG00000129048
resolver
ensp
ENSP00000249887
resolver
ensp
ENSP00000548729
resolver
ensp
ENSP00000634768
resolver
enst
ENST00000249887
resolver
enst
ENST00000878670
resolver
enst
ENST00000964709
resolver
genesymbol
ACKR4
resolver
genesymbol_syn
CCBP2
resolver
genesymbol_syn
CCR11
resolver
genesymbol_syn
CCRL1
resolver
genesymbol_syn
VSHK1
resolver
hgnc
HGNC:1611
resolver
uniprot
B2R9U7
resolver
uniprot_entry
ACKR4_HUMAN
resolver
uniprot_sec
B2R9U7
resolver
amino_acid_sequence
MALEQNQSTDYYYEENEMNGTYDYSQYELICIKEDVREFAKVFLPVFLTIVFVIGLAGNSMVVAIYAYYKKQRTKTDVYILNLAVADLLLLFTLPFWAVNAVHGWVLGKIMCKITSALYTLNFVSGMQFLACISIDRYVAVTKVPSQSGVGKPCWIICFCVWMAAILLSIPQLVFYTVNDNARCIPIFPRYLGTSMKALIQMLEICIGFVVPFLIMGVCYFITARTLMKMPNIKISRPLKVLLTVVIVFIVTQLPYNIVKFCRAIDIIYSLITSCNMSKRMDIAIQVTESIALFHSCLNPILYVFMGASFKNYVMKVAKKYGSWRRQRQSVEEFPFDSEGPTEPTSTFSI
uniprot
proteins
function
FUNCTION: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus. {ECO:0000269|PubMed:10706668, ECO:0000269|PubMed:23121557, ECO:0000269|PubMed:23341447}.
uniprot
proteins
mass_dalton
39914
uniprot
proteins
post_translational_modification
PTM: The Ser/Thr residues in the C-terminal cytoplasmic tail may be phosphorylated.
uniprot
proteins
protein_family
Atypical chemokine receptor subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10706668
uniprot
proteins
pubmed
10734104
uniprot
proteins
pubmed
10767544
uniprot
proteins
pubmed
11981810
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20373092
uniprot
proteins
pubmed
22698181
uniprot
proteins
pubmed
23121557
uniprot
proteins
pubmed
23341447
uniprot
proteins
pubmed
23356288
uniprot
proteins
sequence_length
350
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:23341447}. Recycling endosome {ECO:0000269|PubMed:23341447}. Cell membrane {ECO:0000269|PubMed:23341447}; Multi-pass membrane protein {ECO:0000269|PubMed:23341447}. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.
uniprot
proteins
transmembrane_region
TRANSMEM 43..63; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 88..108; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 114..134; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 155..175; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 202..222; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 241..261; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 290..310; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins