KHDRBS3
entrez
10656
canonical
uniprot
O75525
canonical
ensembl
ENSG00000131773
resolver
ensp
ENSP00000348108
resolver
ensp
ENSP00000431022
resolver
genesymbol
KHDRBS3
resolver
genesymbol_syn
SALP
resolver
genesymbol_syn
SLM2
resolver
hgnc
HGNC:18117
resolver
uniprot
Q6NUL8
resolver
uniprot
Q9UPA8
resolver
uniprot_entry
KHDR3_HUMAN
resolver
uniprot_sec
Q6NUL8
resolver
uniprot_sec
Q9UPA8
resolver
amino_acid_sequence
MEEKYLPELMAEKDSLDPSFTHALRLVNQEIEKFQKGEGKDEEKYIDVVINKNMKLGQKVLIPVKQFPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGKGSMRDKAKEEELRKSGEAKYFHLNDDLHVLIEVFAPPAEAYARMGHALEEIKKFLIPDYNDEIRQAQLQELTYLNGGSENADVPVVRGKPTLRTRGVPAPAITRGRGGVTARPVGVVVPRGTPTPRGVLSTRGPVSRGRGLLTPRARGVPPTGYRPPPPPPTQETYGEYDYDDGYGTAYDEQSYDSYDNSYSTPAQSGADYYDYGHGLSEETYDSYGQEEWTNSRHKAPSARTAKGVYRDQPYGRY
uniprot
proteins
function
FUNCTION: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro. Binds optimally to RNA containing 5'-[AU]UAA-3' as a bipartite motif spaced by more than 15 nucleotides. Binds poly(A). RNA-binding abilities are down-regulated by tyrosine kinase PTK6 (PubMed:10564820, PubMed:19561594, PubMed:26758068). Involved in splice site selection of vascular endothelial growth factor (PubMed:15901763). In vitro regulates CD44 alternative splicing by direct binding to purine-rich exonic enhancer (By similarity). Can regulate alternative splicing of neurexins NRXN1-3 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners such as neuroligins and LRRTM family members (PubMed:26758068). Targeted, cell-type specific splicing regulation of NRXN1 at AS4 is involved in neuronal glutamatergic synapse function and plasticity (By similarity). May regulate expression of KHDRBS2/SLIM-1 in defined brain neuron populations by modifying its alternative splicing (By similarity). Can bind FABP9 mRNA (By similarity). May play a role as a negative regulator of cell growth. Inhibits cell proliferation. {ECO:0000250|UniProtKB:Q9JLP1, ECO:0000250|UniProtKB:Q9R226, ECO:0000269|PubMed:10564820, ECO:0000269|PubMed:15901763, ECO:0000269|PubMed:19561594, ECO:0000269|PubMed:26758068}.; FUNCTION: (Microbial infection) Involved in post-transcriptional regulation of HIV-1 gene expression. {ECO:0000269|PubMed:11741900}.
uniprot
proteins
mass_dalton
38800
uniprot
proteins
mutagenesis
MUTAGEN 141; /note="Y->E: Fails to influence alternative splicing of CD44, NRXN2 and NRXN3."; /evidence="ECO:0000269|PubMed:26758068"; MUTAGEN 212..251; /note="Missing: Complete loss of SIAH1-mediated degradation."; /evidence="ECO:0000269|PubMed:15163637"; MUTAGEN 327..346; /note="Missing: Complete loss of nuclear sublocalization."; /evidence="ECO:0000269|PubMed:11714634
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues. Isoform 1 C-terminal region is tyrosine-rich, but isoform 2 lacking this C-terminal region is also tyrosine-phosphorylated. {ECO:0000269|PubMed:10564820}.
uniprot
proteins
protein_family
KHDRBS family
uniprot
proteins
pubmed
10077576
uniprot
proteins
pubmed
10332027
uniprot
proteins
pubmed
10564820
uniprot
proteins
pubmed
10749975
uniprot
proteins
pubmed
11714634
uniprot
proteins
pubmed
11741900
uniprot
proteins
pubmed
15163637
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15901763
uniprot
proteins
pubmed
19561594
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21725612
uniprot
proteins
pubmed
26758068
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
346
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10332027, ECO:0000269|PubMed:15901763}. Note=Localized in a compartment adjacent to the nucleolus, but distinct from the peri-nucleolar one.
uniprot
proteins