RGS20
entrez
8601
canonical
uniprot
O76081
canonical
ensembl
ENSG00000147509
resolver
ensp
ENSP00000276500
resolver
ensp
ENSP00000297313
resolver
ensp
ENSP00000344630
resolver
ensp
ENSP00000430627
resolver
enst
ENST00000522225
resolver
genesymbol
RGS20
resolver
genesymbol_syn
RGSZ1
resolver
genesymbol_syn
ZGAP1
resolver
hgnc
HGNC:14600
resolver
uniprot
B3KSW4
resolver
uniprot
F6Y0A6
resolver
uniprot
H9NIM5
resolver
uniprot
Q96BG9
resolver
uniprot_entry
B3KSW4_HUMAN
resolver
uniprot_entry
F6Y0A6_HUMAN
resolver
uniprot_entry
H9NIM5_HUMAN
resolver
uniprot_entry
RGS20_HUMAN
resolver
uniprot_sec
Q96BG9
resolver
amino_acid_sequence
MPQLSQDNQECLQKHFSRPSIWTQFLPLFRAQRYNTDIHQITENEGDLRAVPDIKSFPPAQLPDSPAAPKLFGLLSSPLSSLARFFSHLLRRPPPEAPRRRLDFSPLLPALPAARLSRGHEELPGRLSLLLGAALALPGRPSGGRPLRPPHPVAKPREEDATAGQSSPMPQMGSERMEMRKRQMPAAQDTPGAAPGQPGAGSRGSNACCFCWCCCCSCSCLTVRNQEDQRPTIASHELRADLPTWEESPAPTLEEVNAWAQSFDKLMVTPAGRNAFREFLRTEFSEENMLFWMACEELKKEANKNIIEEKARIIYEDYISILSPKEVSLDSRVREVINRNMVEPSQHIFDDAQLQIYTLMHRDSYPRFMNSAVYKDLLQSLSEKSIEA
uniprot
proteins
function
FUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G protein. Negatively regulates mu-opioid receptor-mediated activation of the G proteins (By similarity). {ECO:0000250, ECO:0000269|PubMed:12379657}.
uniprot
proteins
mass_dalton
43692
uniprot
proteins
post_translational_modification
PTM: Fatty acylated. Heavily palmitoylated in the cysteine string motif (By similarity). {ECO:0000250}.; PTM: N- and O-glycosylated in synapsomal membranes. {ECO:0000250}.; PTM: Serine phosphorylated in synapsomal membranes. {ECO:0000250}.; PTM: Sumoylated with SUMO1 and SUMO2 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
11735229
uniprot
proteins
pubmed
12379657
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9748279
uniprot
proteins
pubmed
9748280
uniprot
proteins
sequence_length
388
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Lipid-anchor. Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm/cell membrane and the nucleus. Anchored to the membrane through palmitoylation. {ECO:0000250}.
uniprot
proteins