Rnase6
entrez
78416
canonical
uniprot
Q9D244
canonical
ensembl
ENSMUSG00000021880
resolver
ensp
ENSMUSP00000093613
resolver
ensp
ENSMUSP00000154125
resolver
enst
ENSMUST00000095923
resolver
enst
ENSMUST00000226194
resolver
genesymbol
Rnase6
resolver
uniprot
A2RTT6
resolver
uniprot
F7BN92
resolver
uniprot
Q3V3L3
resolver
uniprot
Q6QDX5
resolver
uniprot_entry
F7BN92_MOUSE
resolver
uniprot_entry
Q3V3L3_MOUSE
resolver
uniprot_entry
RNAS6_MOUSE
resolver
uniprot_sec
A2RTT6
resolver
uniprot_sec
Q6QDX5
resolver
amino_acid_sequence
MVVDLPRYLPLLLLLELWEPMYLLCSQPKGLSRAHWFEIQHIQTSRQPCNTAMRGVNNYTQHCKQINTFLHESFQNVAATCSLHNITCKNGRKNCHESAEPVKMTDCSHTGGAYPNCRYSSDKQYKFFIVACEHPKKEDPPYQLVPVHLDKIV
uniprot
proteins
ec_number
3.1.27.-
uniprot
proteins
function
FUNCTION: Ribonuclease which shows a preference for the pyrimidines uridine and cytosine (PubMed:15693621). Has potent antibacterial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli (PubMed:15693621, PubMed:25075772). Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria (By similarity). Probably contributes to urinary tract sterility (PubMed:25075772). Bactericidal activity is independent of RNase activity (By similarity). {ECO:0000250|UniProtKB:Q93091, ECO:0000269|PubMed:15693621, ECO:0000269|PubMed:25075772}.
uniprot
proteins
mass_dalton
17675
uniprot
proteins
protein_family
Pancreatic ribonuclease family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15693621
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
25075772
uniprot
proteins
sequence_length
153
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25075772}. Lysosome {ECO:0000305|PubMed:25075772}. Cytoplasmic granule {ECO:0000269|PubMed:25075772}.
uniprot
proteins