Csnk1g2
entrez
103236
canonical
uniprot
Q8BVP5
canonical
ensembl
ENSMUSG00000003345
resolver
ensp
ENSMUSP00000078706
resolver
ensp
ENSMUSP00000082560
resolver
ensp
ENSMUSP00000188333
resolver
enst
ENSMUST00000079773
resolver
enst
ENSMUST00000085435
resolver
genesymbol
Csnk1g2
resolver
genesymbol_syn
Ck1g2
resolver
uniprot
F6TLN7
resolver
uniprot
Q99K78
resolver
uniprot_entry
F6TLN7_MOUSE
resolver
uniprot_entry
KC1G2_MOUSE
resolver
uniprot_entry
Q99K78_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Stimulated by estrogen. {ECO:0000269|PubMed:15077195}.
uniprot
proteins
amino_acid_sequence
MDFDKKGGKGELEEGRRMSKTGTSRSNHGVRSSGTSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSTTEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGSKRQHSIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCESFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRSGYVFDYEYDWAGKPLPTPIGTVHPDVPSQPPHRDKAQLHTKNQALNSTNGELNTDDPTAGHSNAPIAAPAEVEVADETKCCCFFKRRKRKSLQRHK
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates MTA1 (PubMed:15077195). Phosphorylates COL4A3BP/CERT and SMAD3. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation (By similarity). Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate (PubMed:16014721). Involved in regulation of reactive oxygen species (ROS) levels (By similarity). {ECO:0000250|UniProtKB:P48729, ECO:0000250|UniProtKB:P78368, ECO:0000269|PubMed:15077195, ECO:0000269|PubMed:16014721}.
uniprot
proteins
mass_dalton
47582
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. Phosphorylated by aPKC which promotes dissociation from the cell cortex. {ECO:0000250|UniProtKB:P78368}.
uniprot
proteins
protein_family
CK1 Ser/Thr protein kinase family
uniprot
proteins
protein_family
Casein kinase I subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15077195
uniprot
proteins
pubmed
16014721
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
415
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cell cortex {ECO:0000250|UniProtKB:P78368}. Cytoplasm {ECO:0000250|UniProtKB:P78368}.
uniprot
proteins