Alx1
entrez
216285
canonical
uniprot
Q8C8B0
canonical
ensembl
ENSMUSG00000036602
resolver
ensp
ENSMUSP00000042512
resolver
ensp
ENSMUSP00000129230
resolver
ensp
ENSMUSP00000151776
resolver
ensp
ENSMUSP00000152017
resolver
ensp
ENSMUSP00000152018
resolver
enst
ENSMUST00000040859
resolver
enst
ENSMUST00000167156
resolver
enst
ENSMUST00000217946
resolver
enst
ENSMUST00000218282
resolver
enst
ENSMUST00000219194
resolver
genesymbol
Alx1
resolver
genesymbol_syn
Cart1
resolver
uniprot
A0A1W2P8B9
resolver
uniprot
Q8C370
resolver
uniprot_entry
A0A1W2P8B9_MOUSE
resolver
uniprot_entry
ALX1_MOUSE
resolver
uniprot_sec
Q8C370
resolver
amino_acid_sequence
MEFLSEKFALKSPPSKNSDFYMGTGGALEHVMETLDNESFYGKATAGKCVQAFGPLPRAEHHVRLDRTSPCQDSSVNYGITKVEGQPLHTELNRAMDNCNNLRMSPVKGMPEKSELDELGDKCDSNVSSSKKRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNRRAKWRKRERYGQIQQAKSHFAATYDISVLPRTDSYPQIQNNLWAGNASGGSVVTSCMLPRDASSCMTPYSHSPRTDSSYTGFSNHQNQFSHVPLNNFFTDSLLTGATNGHAFETKPEFERRSSSIAVLRMKAKEHTANISWAM
uniprot
proteins
function
FUNCTION: Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes (PubMed:12929931). Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival (PubMed:8673125). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (By similarity). {ECO:0000250|UniProtKB:Q15699, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:8673125}.
uniprot
proteins
mass_dalton
36931
uniprot
proteins
mutagenesis
MUTAGEN 131; /note="K->R: Loss of acetylation. Decreased binding affinity to EP300. Loss of EP300-mediated transcriptional coactivation."; /evidence="ECO:0000269|PubMed:12929931
uniprot
proteins
post_translational_modification
PTM: Acetylated at Lys-131 by EP300; increases interaction with EP300 and stimulates ALX1 transcriptional activity. {ECO:0000269|PubMed:12929931}.
uniprot
proteins
protein_family
Paired homeobox family
uniprot
proteins
pubmed
12929931
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
8673125
uniprot
proteins
sequence_length
326
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12929931}.
uniprot
proteins