Itpr2
entrez
16439
canonical
uniprot
Q9Z329
canonical
ensembl
ENSMUSG00000030287
resolver
ensp
ENSMUSP00000049584
resolver
ensp
ENSMUSP00000078526
resolver
genesymbol
Itpr2
resolver
genesymbol_syn
Itpr5
resolver
uniprot
B2KF91
resolver
uniprot
P70226
resolver
uniprot
Q5DWM3
resolver
uniprot
Q5DWM5
resolver
uniprot
Q61744
resolver
uniprot
Q8CED6
resolver
uniprot
Q8R3B0
resolver
uniprot_entry
ITPR2_MOUSE
resolver
uniprot_entry
Q8CED6_MOUSE
resolver
uniprot_sec
B2KF91
resolver
uniprot_sec
P70226
resolver
uniprot_sec
Q5DWM3
resolver
uniprot_sec
Q5DWM5
resolver
uniprot_sec
Q61744
resolver
uniprot_sec
Q8R3B0
resolver
activity_regulation
ACTIVITY REGULATION: Inositol 1,4,5-trisphosphate-gated calcium channel activity is increased by cAMP that occurs independently of PKA activation (PubMed:20189985). ATP and cytosolic calcium modulate the open probability (Po) predominantly by facilitating extended 'bursting' activity of the channel (PubMed:22547632). Inositol 1,4,5-trisphosphate-gated calcium channel activity is inhibited by CALM1 in a calcium-dependent manner (By similarity). {ECO:0000250|UniProtKB:P29995, ECO:0000269|PubMed:20189985, ECO:0000269|PubMed:22547632}.
uniprot
proteins
amino_acid_sequence
MSDKMSSFLYIGDIVSLYAEGSVNGFISTLGLVDDRCVVHPEAGDLANPPKKFRDCLFKVCPMNRYSAQKQYWKAKQAKQGNHTEAALLKKLQHAAELEQKQNESENRKLLGEIVKYSNVIQLLHIKSNKYLTVNKRLPALLEKNAMRVSLDAAGNEGSWFYIHPFWKLRSEGDNIVVGDKVVLMPVNAGQPLHASNVELLDNPGCKEVNAVNCNTSWKITLFMKFSSYREDVLKGGDVVRLFHAEQEKFLTCDDYEKKQHIFLRTTLRQSATSATSSKALWEIEVVHHDPCRGGAGQWNSLFRFKHLATGNYLAAELNPDYRDAQNEGKNVKDGEIPTPKKKRQAGEKIMYTLVSVPHGNDIASLFELDATTLQRADCLVPRNSYVRLRHLCTNTWVTSTTIPIDTEEERPVMLKIGTCQTKEDKEAFAIVCVPLSEVRDLDFANDANKVLATTVKKLENGSITQNERRFVTKLLEDLIFFVADVTNNGQDVLDVVITKPNRERQKLMREQNILAQVFGILKAPFKEKAGEGSMLRLEDLGDQRYAPYKYVLRLCYRVLRHSQQDYRKNQEYIAKNFCVMQSQIGYDILAEDTITALLHNNRKLLEKHITAKEIETFVSLLRRNREPRFLDYLSDLCVSNSTAIPVTQELICKFMLSPGNADILIQTKLVSMQVENPMESSILPDDIDDEEVWLYWIDSNKEPHGKAIRHLAQEAREGTKADLEVLTYYRYQLNLFARMCLDRQYLAINQISTQLSVDLILRCVSDESLPFDLRASFCRLMLHMHVDRDPQESVVPVRYARLWTEIPTKITIHEYDSITDSSRNDMKRKFALTMEFVEEYLKEVVNQPFPFGDKEKNKLTFEVVHLARNLIYFGFYSFSELLRLTRTLLAILDIVQAPMSSYFERLSKFQDGSNNVMRTIHGVGEMMTQMVLSRGSIFPVSVPDAQPIVHPSKQASPGEQEDVTVMDTKLKVIEILQFILSVRLDYRISYMLSIYKKEFGDNNDNGDPSASGTPDTLLPSALVPDIDEIAAQAETMFAGRKEKTPVQLDDEGGRTFLRVLIHLIMHDYAPLLSGALQLLFKHFSQRAEVLQAFKQVQLLVSNQDVDNYKQIKADLDQLRLTVEKSELWVEKSGSYENGDVGEGQAKGGEEANEESNLLSPVQDGAKTPQIDSNKGNNYRIVKEILIRLSKLCVQNKKCRNQHQRLLKNMGAHSVVLDLLQIPYEKTDEKMNEVMDLAHTFLQNFCRGNPQNQVLLHKHLNLFLTPGLLEAETMRHIFMNNYHLCNEISERVVQHFVHCIETHGRHVEYLRFLQTIVKADGKYVKKCQDMVMTELINGGEDVLIFYNDRASFPILLNMMCSERARGDESGPLAYHITLVELLAACTEGKNVYTEIKCNSLLPLDDIVRVVTHDDCIPEVKIAYVNFVNHCYVDTEVEMKEIYTSNHIWKLFENFLVDMARVCNTTTDRKHADTFLERCVTESVMNIVSGFFNSPFSDNSTSLQTHQPVFIQLLQSAFRIYNCTWPNPAQKASVESCIRALAEVAKNRGIAIPVDLDSQVNTLFMKNHSSTVQRAAMGWRLSARSGPRFKEALGGPAWDYRNIIEKLQDVVASLEQQFSPMMQAEFSVLVDVLYSPELLFPEGSDARIRCGAFMSKLINHTKKLMEKEEKLCIKILQTLREMLEKKDSFMEEGSTLRRILLNRYFKGDHSISVNGPLSGAYAKTAQVGGSFSGQDSDKKGISMSDIQCLLDKEGASELVIDVIVNTKNDRIFSEGILLGIALLEGGNTQTQYSFYQQLHEQKKSEKFFKVLYDRMKAAQKEIRSTVTVNTIDLGSKKREEDSDVMALGPRMRVRDSSLHLREGMKGQLTEASSATSKAYCVYRREMDPEIDTMCPGQEAGSAEEKSAEEVTMSPAITIMRPILRFLQLLCENHNRELQNFLRNQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINERNVALVNQTLESLTEYCQGPCHENQTCIATHESNGIDIIIALILNDINPLGKYRMDLVLQLKNNASKLLLAIMESRHDSENAERILFNMRPRELVDVMKNAYNQGLECDHGDEEGGDDGVSPKDVGHNIYILAHQLARHNKLLQQMLKPGSDPEEGDEALKYYANHTAQIEIVRHDRTMEQIVFPVPNICEFLTRESKYRVFNTTERDEQGSKVNDFFQQTEDLYNEMKWQKKIRNNPALFWFSRHISLWGSISFNLAVFINLAVALFYPFGDDGDEGTLSPMFSVLLWVAVAICTSMLFFFSKPVGIRPFLVSVMLRSIYTIGLGPTLILLGAANLCNKIVFLVSFVGNRGTFTRGYRAVILDMAFLYHVAYVLVCMLGLFVHEFFYSFLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIIGFLFLKDDFTMEVDRLKNRTPVTGNHGVPTMTLSSMMETCQKENCSPTIPSSNTAGEEGEDGIERTCDTLLMCIVTVLNQGLRNGGGVGDVLRRPSKDEPLFAARVVYDLLFFFIVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVSFEEHIKSEHNMWHYLYFIVLVKVKDPTEYTGPESYVAQMITEKNLDWFPRMRAMSLVSNEGDSEQNEIRNLQEKLESTMSLVKQLSGQLAELKEQMTEQRKNKQRLGFLGSNTPHVNHHMPPH
uniprot
proteins
function
FUNCTION: Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm (PubMed:15632133, PubMed:19608738, PubMed:20189985, PubMed:22547632, PubMed:25329695). Exists in two states; a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity (PubMed:22547632). {ECO:0000269|PubMed:15632133, ECO:0000269|PubMed:19608738, ECO:0000269|PubMed:20189985, ECO:0000269|PubMed:22547632, ECO:0000269|PubMed:25329695}.; FUNCTION: [Isoform 3]: Has neither inositol 1,4,5-trisphosphate binding activity nor calcium releasing activity. {ECO:0000269|PubMed:15632133}.
uniprot
proteins
mass_dalton
307475
uniprot
proteins
mutagenesis
MUTAGEN 507; /note="K->A: Loss of binding activity."; /evidence="ECO:0000269|PubMed:15632133"; MUTAGEN 510; /note="R->A: Loss of binding activity."; /evidence="ECO:0000269|PubMed:15632133"; MUTAGEN 937; /note="S->A: Abolishes PKA-mediated phosphorylation. No enhanced calcium release. Abolishes PKA-mediated phosphorylation: When associated with A-990; A-1190; A-1351 and A-1581."; /evidence="ECO:0000269|PubMed:19608738"; MUTAGEN 990; /note="S->A: No effect on PKA-mediated phosphorylation. Abolishes PKA-mediated phosphorylation: When associated with A-937; A-1190; A-1351 and A-1581."; /evidence="ECO:0000269|PubMed:19608738"; MUTAGEN 1190; /note="S->A: No effect on PKA-mediated phosphorylation. Abolishes PKA-mediated phosphorylation: When associated with A-937; A-990; A-1351 and A-1581."; /evidence="ECO:0000269|PubMed:19608738"; MUTAGEN 1351; /note="S->A: No effect on PKA-mediated phosphorylation. Abolishes PKA-mediated phosphorylation: When associated with A-937; A-990; A-1190 and A-1581."; /evidence="ECO:0000269|PubMed:19608738"; MUTAGEN 1581; /note="S->A: No effect on PKA-mediated phosphorylation. Abolishes PKA-mediated phosphorylation: When associated with A-937; A-990; A-1190 and A-1351."; /evidence="ECO:0000269|PubMed:19608738"; MUTAGEN 2498; /note="G->S: Impairs inositol 1,4,5-trisphosphate-gated calcium channel activity."; /evidence="ECO:0000269|PubMed:25329695"; MUTAGEN 2633; /note="S->A: No effect on PKA-mediated phosphorylation. Enhanced calcium release on PKA activation."; /evidence="ECO:0000269|PubMed:19608738
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by cAMP-dependent PKA on Ser-937 increases calcium release. {ECO:0000269|PubMed:19608738}.; PTM: Phosphorylation by CaMK2 on Ser-150 significantly decreases the channel open probability. {ECO:0000250|UniProtKB:P29995}.
uniprot
proteins
protein_family
InsP3 receptor family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15632133
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19608738
uniprot
proteins
pubmed
20189985
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22547632
uniprot
proteins
pubmed
25329695
uniprot
proteins
pubmed
8063813
uniprot
proteins
pubmed
9065779
uniprot
proteins
pubmed
9729462
uniprot
proteins
sequence_length
2701
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15632133}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q8WN96}; Multi-pass membrane protein {ECO:0000255}. Note=Forms clusters on endoplasmic reticulum membrane upon inositol 1,4,5-trisphosphate binding. {ECO:0000269|PubMed:15632133}.
uniprot
proteins
transmembrane_region
TRANSMEM 2228..2248; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 2261..2281; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 2308..2328; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 2352..2372; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 2395..2415; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 2521..2541; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins