EEA1
entrez
8411
canonical
uniprot
Q15075
canonical
ensembl
ENSG00000102189
resolver
ensp
ENSP00000317955
resolver
enst
ENST00000322349
resolver
genesymbol
EEA1
resolver
genesymbol_syn
ZFYVE2
resolver
hgnc
HGNC:3185
resolver
uniprot
Q14221
resolver
uniprot_entry
EEA1_HUMAN
resolver
uniprot_sec
Q14221
resolver
amino_acid_sequence
MLRRILQRTPGRVGSQGSDLDSSATPINTVDVNNESSSEGFICPQCMKSLGSADELFKHYEAVHDAGNDSGHGGESNLALKRDDVTLLRQEVQDLQASLKEEKWYSEELKKELEKYQGLQQQEAKPDGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLREAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERERESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQKNQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEINQLHSKLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQIGDKDQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAVLNQLQEKNHTLQEQVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLETSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQDKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKKILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKEKSLKEKELVNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITNLKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDERRALLERCLKGEGEIEKLQTKVLELQRKLDNTTAAVQELGRENQSLQIKHTQALNRKWAEDNEVQNCMACGKGFSVTVRRHHCRQCGNIFCAECSAKNALTPSSKKPVRVCDACFNDLQG
uniprot
proteins
function
FUNCTION: Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.
uniprot
proteins
mass_dalton
162466
uniprot
proteins
mutagenesis
MUTAGEN 39; /note="E->A: Strongly reduces interaction with RAB5C."; /evidence="ECO:0000269|PubMed:12493736"; MUTAGEN 41; /note="F->A: Strongly reduces interaction with RAB5C."; /evidence="ECO:0000269|PubMed:12493736"; MUTAGEN 42; /note="I->A: Strongly reduces interaction with RAB5C."; /evidence="ECO:0000269|PubMed:12493736"; MUTAGEN 44; /note="P->A: Strongly reduces interaction with RAB5C."; /evidence="ECO:0000269|PubMed:12493736"; MUTAGEN 47; /note="M->A: Strongly reduces interaction with RAB5C."; /evidence="ECO:0000269|PubMed:12493736"; MUTAGEN 60; /note="Y->A: Strongly reduces interaction with RAB5C."; /evidence="ECO:0000269|PubMed:12493736"; MUTAGEN 1349; /note="W->A: Reduces phosphatidylinositol 3-phosphate binding and endosomal location."; /evidence="ECO:0000269|PubMed:10807926"; MUTAGEN 1352; /note="D->V: Reduces phosphatidylinositol 3-phosphate binding and endosomal location."; /evidence="ECO:0000269|PubMed:10394369"; MUTAGEN 1357; /note="N->D: Reduces phosphatidylinositol 3-phosphate binding and endosomal location."; /evidence="ECO:0000269|PubMed:10394369"; MUTAGEN 1358; /note="C->S: Abolishes phosphatidylinositol 3-phosphate binding and endosomal location."; /evidence="ECO:0000269|PubMed:10807926"; MUTAGEN 1365; /note="F->A: Strongly reduces phosphatidylinositol 3-phosphate binding and endosomal location."; /evidence="ECO:0000269|PubMed:10807926"; MUTAGEN 1367..1368; /note="VT->EE,GG: Abolishes phosphatidylinositol 3-phosphate binding and endosomal location."; /evidence="ECO:0000269|PubMed:10394369"; MUTAGEN 1370; /note="R->A: Abolishes endosomal location."; /evidence="ECO:0000269|PubMed:10807926"; MUTAGEN 1371; /note="R->A: Abolishes phosphatidylinositol 3-phosphate binding and endosomal location."; /evidence="ECO:0000269|PubMed:10807926"; MUTAGEN 1372; /note="H->A: Abolishes endosomal location. Abolishes pH sensitivity of the FYVE-type zinc finger domain; when associated with A-1373."; /evidence="ECO:0000269|PubMed:10807926, ECO:0000269|PubMed:19296456"; MUTAGEN 1373; /note="H->A: Abolishes phosphatidylinositol 3-phosphate binding and endosomal location. Abolishes pH sensitivity of the FYVE-type zinc finger domain; when associated with A-1372."; /evidence="ECO:0000269|PubMed:10807926, ECO:0000269|PubMed:19296456"; MUTAGEN 1374; /note="C->A: Abolishes phosphatidylinositol 3-phosphate binding and endosomal location."; /evidence="ECO:0000269|PubMed:10807926"; MUTAGEN 1375; /note="R->G: Abolishes phosphatidylinositol 3-phosphate binding and endosomal location."; /evidence="ECO:0000269|PubMed:10394369, ECO:0000269|PubMed:10807926"; MUTAGEN 1377; /note="C->A: Abolishes phosphatidylinositol 3-phosphate binding and endosomal location."; /evidence="ECO:0000269|PubMed:10807926"; MUTAGEN 1378; /note="G->A: Abolishes phosphatidylinositol 3-phosphate binding and endosomal location."; /evidence="ECO:0000269|PubMed:10807926"; MUTAGEN 1385; /note="C->A: Abolishes phosphatidylinositol 3-phosphate binding and endosomal location."; /evidence="ECO:0000269|PubMed:10807926"; MUTAGEN 1400; /note="R->G: Strongly reduces phosphatidylinositol 3-phosphate binding and abolishes endosomal location."; /evidence="ECO:0000269|PubMed:10394369, ECO:0000269|PubMed:10807926"; MUTAGEN 1405; /note="C->S: Abolishes phosphatidylinositol 3-phosphate binding and endosomal location."; /evidence="ECO:0000269|PubMed:10807926
uniprot
proteins
pubmed
10394369
uniprot
proteins
pubmed
10491193
uniprot
proteins
pubmed
10506127
uniprot
proteins
pubmed
10807926
uniprot
proteins
pubmed
11230696
uniprot
proteins
pubmed
11741531
uniprot
proteins
pubmed
11870209
uniprot
proteins
pubmed
12493736
uniprot
proteins
pubmed
16086013
uniprot
proteins
pubmed
16314522
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
19296456
uniprot
proteins
pubmed
19725050
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22816767
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24029230
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
7768953
uniprot
proteins
pubmed
9697774
uniprot
proteins
sequence_length
1411
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:16086013, ECO:0000269|PubMed:7768953}; Peripheral membrane protein {ECO:0000269|PubMed:7768953}. Cytoplasm {ECO:0000269|PubMed:7768953}.
uniprot
proteins