NPLOC4
entrez
55666
canonical
uniprot
Q8TAT6
canonical
ensembl
ENSG00000182446
resolver
ensp
ENSP00000331487
resolver
ensp
ENSP00000363879
resolver
genesymbol
NPLOC4
resolver
genesymbol_syn
KIAA1499
resolver
genesymbol_syn
NPL4
resolver
hgnc
HGNC:18261
resolver
uniprot
Q8N3J1
resolver
uniprot
Q9H8V2
resolver
uniprot
Q9H964
resolver
uniprot
Q9NWR5
resolver
uniprot
Q9P229
resolver
uniprot_entry
NPL4_HUMAN
resolver
uniprot_sec
Q8N3J1
resolver
uniprot_sec
Q9H8V2
resolver
uniprot_sec
Q9H964
resolver
uniprot_sec
Q9NWR5
resolver
uniprot_sec
Q9P229
resolver
amino_acid_sequence
MAESIIIRVQSPDGVKRITATKRETAATFLKKVAKEFGFQNNGFSVYINRNKTGEITASSNKSLNLLKIKHGDLLFLFPSSLAGPSSEMETSVPPGFKVFGAPNVVEDEIDQYLSKQDGKIYRSRDPQLCRHGPLGKCVHCVPLEPFDEDYLNHLEPPVKHMSFHAYIRKLTGGADKGKFVALENISCKIKSGCEGHLPWPNGICTKCQPSAITLNRQKYRHVDNIMFENHTVADRFLDFWRKTGNQHFGYLYGRYTEHKDIPLGIRAEVAAIYEPPQIGTQNSLELLEDPKAEVVDEIAAKLGLRKVGWIFTDLVSEDTRKGTVRYSRNKDTYFLSSEECITAGDFQNKHPNMCRLSPDGHFGSKFVTAVATGGPDNQVHFEGYQVSNQCMALVRDECLLPCKDAPELGYAKESSSEQYVPDVFYKDVDKFGNEITQLARPLPVEYLIIDITTTFPKDPVYTFSISQNPFPIENRDVLGETQDFHSLATYLSQNTSSVFLDTISDFHLLLFLVTNEVMPLQDSISLLLEAVRTRNEELAQTWKRSEQWATIEQLCSTVGGQLPGLHEYGAVGGSTHTATAAMWACQHCTFMNQPGTGHCEMCSLPRT
uniprot
proteins
function
FUNCTION: The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (PubMed:26471729). {ECO:0000250|UniProtKB:Q9ES54, ECO:0000269|PubMed:26471729}.
uniprot
proteins
mass_dalton
68120
uniprot
proteins
mutagenesis
MUTAGEN 6..8; /note="IIR->AIA: Abolished interaction with VCP; when associated with A-17 and A-50."; /evidence="ECO:0000269|PubMed:26471729"; MUTAGEN 17; /note="R->A: Abolished interaction with VCP; when associated with 6-A--A-8 and A-50."; /evidence="ECO:0000269|PubMed:26471729"; MUTAGEN 50; /note="R->A: Abolished interaction with VCP; when associated with 6-A--A-8 and A-17."; /evidence="ECO:0000269|PubMed:26471729
uniprot
proteins
pathway_participation
PATHWAY: Protein degradation; proteasomal ubiquitin-dependent pathway.
uniprot
proteins
protein_family
NPL4 family
uniprot
proteins
pubmed
10819331
uniprot
proteins
pubmed
11574150
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24160817
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26471729
uniprot
proteins
sequence_length
608
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9ES54}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9ES54}. Nucleus {ECO:0000250|UniProtKB:Q9ES54}. Note=Associated with the endoplasmic reticulum and nuclear. {ECO:0000250|UniProtKB:Q9ES54}.
uniprot
proteins