Tmem35a
entrez
67564
canonical
uniprot
Q9D328
canonical
ensembl
ENSMUSG00000033578
resolver
ensp
ENSMUSP00000044926
resolver
enst
ENSMUST00000037687
resolver
genesymbol
Tmem35a
resolver
genesymbol_syn
Nacho
resolver
genesymbol_syn
Tmem35
resolver
uniprot
Q9DB64
resolver
uniprot_entry
NACHO_MOUSE
resolver
uniprot_sec
Q9DB64
resolver
amino_acid_sequence
MASPRTITIMALSVALGLFFVFMGTIKLTPRLSKDAYSEMKRAYKSYVRALPLLKKMGINSILLRKSIGALEVACGIVMTLVPGRPKDVANFFLLLLVLAVLFFHQLVGDPLKRYAHALVFGILLTCRLLIARKPEDRSSEKKALPESAEEQPSLYEKAPQGKVKVS
uniprot
proteins
function
FUNCTION: Molecular chaperone which mediates the proper assembly and functional expression of the nicotinic acetylcholine receptors (nAChRs) throughout the brain (PubMed:26875622, PubMed:28445721, PubMed:32204458). Essential for the proper folding, assembly, function and surface trafficking of alpha-7 (CHRNA7), alpha-4-beta-2, alpha-3-beta-2 and alpha-3-beta-4 receptors (PubMed:26875622, PubMed:28445721, PubMed:32204458). Stably associates with ribophorin-1 (RPN1) and ribophorin-2 (RPN2) (components of the oligosaccharyl transferase (OST) complex) and with calnexin (CANX), both of which are critical for NACHO-mediated effects on CHRNA7 assembly and function (PubMed:32783947). Facilitates the proper folding and assembly of alpha-6-beta-2 and alpha-6-beta-2-beta-3 receptors and acts at early stages of the nAChRs subunit assembly (PubMed:28445721). Promotes the expression of the alpha-4(2):beta-2(3) stoichiometric form over the alpha-4(3):beta-2(2) form (By similarity). {ECO:0000250|UniProtKB:Q53FP2, ECO:0000269|PubMed:26875622, ECO:0000269|PubMed:28445721, ECO:0000269|PubMed:32204458, ECO:0000269|PubMed:32783947}.
uniprot
proteins
mass_dalton
18505
uniprot
proteins
protein_family
DoxX family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17768142
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26875622
uniprot
proteins
pubmed
27170659
uniprot
proteins
pubmed
28445721
uniprot
proteins
pubmed
32204458
uniprot
proteins
pubmed
32783947
uniprot
proteins
pubmed
33422618
uniprot
proteins
sequence_length
167
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:17768142}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q6JAM9}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:28445721}; Multi-pass membrane protein {ECO:0000255}. Note=Shedding may lead to a soluble peptide. {ECO:0000250|UniProtKB:Q6JAM9}.
uniprot
proteins
transmembrane_region
TRANSMEM 6..26; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 62..82; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 89..109; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 115..132; /note="Helical; Name=4"; /evidence="ECO:0000255
uniprot
proteins