PASD1
entrez
139135
canonical
uniprot
Q8IV76
canonical
ensembl
ENSG00000166049
resolver
ensp
ENSP00000359382
resolver
genesymbol
PASD1
resolver
hgnc
HGNC:20686
resolver
uniprot
Q3MNE0
resolver
uniprot
Q69HD7
resolver
uniprot
Q8N7X9
resolver
uniprot_entry
PASD1_HUMAN
resolver
uniprot_sec
Q3MNE0
resolver
uniprot_sec
Q69HD7
resolver
uniprot_sec
Q8N7X9
resolver
amino_acid_sequence
MKMRGEKRRDKVNPKSSQRKLNWIPSFPTYDYFNQVTLQLLDGFMITLSTDGVIICVAENISSLLGHLPAEIVGKKLLSLLPDEEKDEVYQKIILKFPLLNSETHIEFCCHLKRGNVEHGDSSAYENVKFIVNVRDICNEFPVVFSGLFSSHLCADFAACVPQEDRLYLVGNVCILRTQLLQQLYTSKAVSDEAVLTQDSDEEPFVGELSSSQGQRGHTSMKAVYVEPAAAAAAAAISDDQIDIAEVEQYGPQENVHMFVDSDSTYCSSTVFLDTMPESPALSLQDFRGEPEVNPLYRADPVDLEFSVDQVDSVDQEGPMDQQDPENPVAPLDQAGLMDPVDPEDSVDLGAAGASAQPLQPSSPVAYDIISQELELMKKLKEQLEERTWLLHDAIQNQQNALELMMDHLQKQPNTLRHVVIPDLQSSEAVPKKQQKQHAGQVKRPLPHPKDVKCFCGLSLSNSLKNTGELQEPCVAFNQQQLVQQEQHLKEQQRQLREQLQQLREQRKVQKQKKMQEKKKLQEQKMQEKKKLQEQRRQKKKKLQERKKWQGQMLQKEPEEEQQKQQLQEQPLKHNVIVGNERVQICLQNPRDVSVPLCNHPVRFLQAQPIVPVQRAAEQQPSGFYQDENCGQQEDESQSFYPEAYQGPPVNQLPLIDTSNSEAISSSSIPQFPITSDSTISTLETPQDYIRLWQELSDSLGPVVQVNTWSCDEQGTLHGQPTYHQVQVSEVGVEGPPDPQAFQGPAAYQPDQMRSAEQTRLMPAEQRDSNKPC
uniprot
proteins
function
FUNCTION: Functions as a suppressor of the biological clock that drives the daily circadian rhythms of cells throughout the body (PubMed:25936801). Acts as a nuclear repressor of the CLOCK-BMAL1 heterodimer-mediated transcriptional activation of the core clock components (PubMed:25936801). Inhibits circadian clock function in cancer cells, when overexpressed (PubMed:25936801). {ECO:0000269|PubMed:25936801}.
uniprot
proteins
mass_dalton
87428
uniprot
proteins
mutagenesis
MUTAGEN 36; /note="V->E: Reduces inhibition of CLOCK-BMAL1 heterodimer activity; when associated with R-45."; /evidence="ECO:0000269|PubMed:25936801"; MUTAGEN 45; /note="M->R: Reduces inhibition of CLOCK-BMAL1 heterodimer activity; when associated with E-36."; /evidence="ECO:0000269|PubMed:25936801
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15162151
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16112646
uniprot
proteins
pubmed
25936801
uniprot
proteins
sequence_length
773
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:25936801}. Note=Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801). {ECO:0000269|PubMed:25936801}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:25936801}. Note=Associates preferentially at the periphery of the nucleus with heterochromatin (PubMed:25936801). {ECO:0000269|PubMed:25936801}.
uniprot
proteins