CUL1
entrez
8454
canonical
uniprot
Q13616
canonical
ensembl
ENSG00000055130
resolver
ensp
ENSP00000326804
resolver
ensp
ENSP00000387160
resolver
ensp
ENSP00000473318
resolver
ensp
ENSP00000499255
resolver
ensp
ENSP00000499277
resolver
ensp
ENSP00000499398
resolver
ensp
ENSP00000539921
resolver
ensp
ENSP00000539922
resolver
ensp
ENSP00000539923
resolver
ensp
ENSP00000539924
resolver
ensp
ENSP00000539925
resolver
ensp
ENSP00000604572
resolver
ensp
ENSP00000604573
resolver
ensp
ENSP00000604575
resolver
ensp
ENSP00000604576
resolver
ensp
ENSP00000641904
resolver
ensp
ENSP00000641909
resolver
enst
ENST00000325222
resolver
enst
ENST00000409469
resolver
enst
ENST00000602748
resolver
enst
ENST00000662716
resolver
enst
ENST00000663044
resolver
enst
ENST00000665936
resolver
enst
ENST00000869862
resolver
enst
ENST00000869863
resolver
enst
ENST00000869864
resolver
enst
ENST00000869865
resolver
enst
ENST00000869866
resolver
enst
ENST00000934513
resolver
enst
ENST00000934514
resolver
enst
ENST00000934516
resolver
enst
ENST00000934517
resolver
enst
ENST00000971845
resolver
enst
ENST00000971850
resolver
genesymbol
CUL1
resolver
hgnc
HGNC:2551
resolver
uniprot
B3KTW0
resolver
uniprot
D3DWG3
resolver
uniprot
O60719
resolver
uniprot
Q08AL6
resolver
uniprot
Q8IYW1
resolver
uniprot_entry
B3KTW0_HUMAN
resolver
uniprot_entry
CUL1_HUMAN
resolver
uniprot_sec
D3DWG3
resolver
uniprot_sec
O60719
resolver
uniprot_sec
Q08AL6
resolver
uniprot_sec
Q8IYW1
resolver
amino_acid_sequence
MSSTRSQNPHGLKQIGLDQIWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSNQARGAGVPPSKSKKGQTPGGAQFVGLELYKRLKEFLKNYLTNLLKDGEDLMDESVLKFYTQQWEDYRFSSKVLNGICAYLNRHWVRRECDEGRKGIYEIYSLALVTWRDCLFRPLNKQVTNAVLKLIEKERNGETINTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKHLEIFHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAALNDPKMYVQTVLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLTNSEPLDLDFSIQVLSSGSWPFQQSCTFALPSELERSYQRFTAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILAQVLQILLKSKLLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEKDTYSYLA
uniprot
proteins
function
FUNCTION: Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins (PubMed:22017875, PubMed:22017877, PubMed:27565346). In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme (PubMed:38326650). The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1 (PubMed:12609982, PubMed:38326650). The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component (PubMed:38326650). SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(BTRC) and/or SCF(FBXW11) direct ubiquitination of CEP68 (PubMed:25503564, PubMed:25704143). SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of CCNE1, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO1) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2. Neddylated CUL1-RBX1 ubiquitinates p53/TP53 recruited by Cul7-RING(FBXW8) complex (PubMed:35982156). SCF(BTRC) directs 'Lys-48'-linked ubiquitination of UBR2 in the T-cell receptor signaling pathway (PubMed:38225265). The SCF(FBXO31) protein ligase complex specifically mediates the ubiquitination of proteins amidated at their C-terminus in response to oxidative stress (PubMed:39880951). {ECO:0000269|PubMed:15531760, ECO:0000269|PubMed:15640526, ECO:0000269|PubMed:18644861, ECO:0000269|PubMed:19679664, ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:22405651, ECO:0000269|PubMed:23263282, ECO:0000269|PubMed:23431138, ECO:0000269|PubMed:25503564, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:27565346, ECO:0000269|PubMed:35982156, ECO:0000269|PubMed:38225265, ECO:0000269|PubMed:38326650, ECO:0000269|PubMed:39880951, ECO:0000269|PubMed:9663463}.
uniprot
proteins
mass_dalton
89679
uniprot
proteins
mutagenesis
MUTAGEN 1..331; /note="Missing: Abolishes interaction with Cul7-RING(FBXW8) complex; does not disrupt interaction with RBX1."; /evidence="ECO:0000269|PubMed:35982156
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:22017875, ECO:0000269|PubMed:22017877, ECO:0000269|PubMed:22405651, ECO:0000269|PubMed:38326650, ECO:0000269|PubMed:39880951}.
uniprot
proteins
post_translational_modification
PTM: Neddylated; which enhances the ubiquitination activity of SCF (PubMed:24076655, PubMed:27565346, PubMed:15537541). Neddylation prevents binding of the inhibitor CAND1 (PubMed:15537541). Neddylation leads to structural rearrangment in the complex that allows interaction between the E2 ubiquitin-conjugating enzyme and the acceptor ubiquitin (PubMed:38326650). Deneddylated via its interaction with the COP9 signalosome (CSN) complex (PubMed:10597293, PubMed:10713156, PubMed:15537541, PubMed:18805092). {ECO:0000269|PubMed:10597293, ECO:0000269|PubMed:10713156, ECO:0000269|PubMed:15537541, ECO:0000269|PubMed:18805092, ECO:0000269|PubMed:24076655, ECO:0000269|PubMed:27565346, ECO:0000269|PubMed:38326650}.; PTM: (Microbial infection) Deneddylated by Epstein-Barr virus BPLF1 leading to a S-phase-like environment that is required for efficient replication of the viral genome (PubMed:20190741). {ECO:0000269|PubMed:20190741}.
uniprot
proteins
protein_family
Cullin family
uniprot
proteins
pubmed
10230406
uniprot
proteins
pubmed
10230407
uniprot
proteins
pubmed
10597293
uniprot
proteins
pubmed
10713156
uniprot
proteins
pubmed
10851089
uniprot
proteins
pubmed
11337588
uniprot
proteins
pubmed
11961546
uniprot
proteins
pubmed
12504026
uniprot
proteins
pubmed
12609982
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15145941
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15531760
uniprot
proteins
pubmed
15537541
uniprot
proteins
pubmed
15640526
uniprot
proteins
pubmed
16714087
uniprot
proteins
pubmed
16797541
uniprot
proteins
pubmed
16880511
uniprot
proteins
pubmed
17098746
uniprot
proteins
pubmed
17254749
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18203720
uniprot
proteins
pubmed
18644861
uniprot
proteins
pubmed
18805092
uniprot
proteins
pubmed
19679664
uniprot
proteins
pubmed
20190741
uniprot
proteins
pubmed
20596027
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21940857
uniprot
proteins
pubmed
22017875
uniprot
proteins
pubmed
22017877
uniprot
proteins
pubmed
22113614
uniprot
proteins
pubmed
22405651
uniprot
proteins
pubmed
22748924
uniprot
proteins
pubmed
23201271
uniprot
proteins
pubmed
23263282
uniprot
proteins
pubmed
23431138
uniprot
proteins
pubmed
23776465
uniprot
proteins
pubmed
24076655
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24192928
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25349211
uniprot
proteins
pubmed
25503564
uniprot
proteins
pubmed
25704143
uniprot
proteins
pubmed
26818844
uniprot
proteins
pubmed
26906416
uniprot
proteins
pubmed
27565346
uniprot
proteins
pubmed
28152074
uniprot
proteins
pubmed
28581483
uniprot
proteins
pubmed
29149593
uniprot
proteins
pubmed
29444943
uniprot
proteins
pubmed
31413110
uniprot
proteins
pubmed
34319780
uniprot
proteins
pubmed
35982156
uniprot
proteins
pubmed
38225265
uniprot
proteins
pubmed
38326650
uniprot
proteins
pubmed
39880951
uniprot
proteins
pubmed
8681378
uniprot
proteins
pubmed
9663463
uniprot
proteins
sequence_length
776
uniprot
proteins