Cpeb3
entrez
208922
canonical
uniprot
Q7TN99
canonical
ensembl
ENSMUSG00000039652
resolver
ensp
ENSMUSP00000078690
resolver
ensp
ENSMUSP00000116172
resolver
ensp
ENSMUSP00000116309
resolver
ensp
ENSMUSP00000118723
resolver
ensp
ENSMUSP00000120416
resolver
ensp
ENSMUSP00000121987
resolver
ensp
ENSMUSP00000311729
resolver
ensp
ENSMUSP00000311733
resolver
ensp
ENSMUSP00000311736
resolver
ensp
ENSMUSP00000311737
resolver
ensp
ENSMUSP00000311738
resolver
ensp
ENSMUSP00000311739
resolver
ensp
ENSMUSP00000311740
resolver
ensp
ENSMUSP00000311744
resolver
ensp
ENSMUSP00000311745
resolver
enst
ENSMUST00000079754
resolver
enst
ENSMUST00000123727
resolver
enst
ENSMUST00000132580
resolver
enst
ENSMUST00000154376
resolver
genesymbol
Cpeb3
resolver
genesymbol_syn
Kiaa0940
resolver
uniprot
A0A0R4J102
resolver
uniprot
A1A562
resolver
uniprot
D3Z1R6
resolver
uniprot
Q3TT89
resolver
uniprot
Q3UHR6
resolver
uniprot
Q8CHC2
resolver
uniprot_entry
A0A0R4J102_MOUSE
resolver
uniprot_entry
CPEB3_MOUSE
resolver
uniprot_entry
D3Z1R6_MOUSE
resolver
uniprot_sec
A1A562
resolver
uniprot_sec
Q3TT89
resolver
uniprot_sec
Q3UHR6
resolver
uniprot_sec
Q8CHC2
resolver
amino_acid_sequence
MQDDLLMDKSKTQPQSQQQQRQQQQQQQQLQPEPGAAEAPSTPLSSEIPKPEDSSAVPALSPASAPPAPNGPDKMQMESPLLPGLSFHQPPQQPPPPQEPTAPGASLSPSFGSTWSTGTTNAVEDSFFQGITPVNGTMLFQNFPHHVNPVFGGTFSPQIGLAQTQHHQQPPPPAPQPPQPAQPPQAQPSQQRRSPASPSQAPYAQRSAAAYGHQPIMTSKPSSSSAVAAAAAAAAASSASSSWNTHQSVNAAWSAPSNPWGGLQAGRDPRRAVGVGVGVGVGVPSPLNPISPLKKPFSSNVIAPPKFPRAAPLTSKSWMEDNAFRTDNGNNLLPFQDRSRPYDTFNLHSLENSLMDMIRTDHEPLKGKHYPNSGPPMSFADIMWRNHFAGRMGINFHHPGTDNIMALNTRSYGRRRGRSSLFPFEDAFLDDSHGDQALSSGLSSPTRCQNGERVERYSRKVFVGGLPPDIDEDEITASFRRFGPLVVDWPHKAESKSYFPPKGYAFLLFQEESSVQALIDACLEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHNDIDKRVEVKPYVLDDQMCDECQGTRCGGKFAPFFCANVTCLQYYCEYCWASIHSRAGREFHKPLVKEGGDRPRHVPFRWS
uniprot
proteins
function
FUNCTION: Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (PubMed:17024188, PubMed:26074072). In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure (PubMed:17024188). Required for the consolidation and maintenance of hippocampal-based long term memory (PubMed:26074003). In the basal state, binds to the mRNA 3'-UTR of the glutamate receptors GRIA1 and GRIA2 and negatively regulates their translation (PubMed:17024188, PubMed:22153079). Also represses the translation of DLG4, GRIN1 GRIN2A and GRIN2B (PubMed:24155305). When activated, acts as a translational activator of GRIA1 and GRIA2 (PubMed:22153079, PubMed:26074003). In the basal state, suppresses SUMO2 translation but activates it following neuronal stimulation (PubMed:26074071). Binds to the 3'-UTR of TRPV1 mRNA and represses TRPV1 translation which is required to maintain normal thermoception (PubMed:26915043). Binds actin mRNA, leading to actin translational repression in the basal state and to translational activation following neuronal stimulation (PubMed:26074072). Negatively regulates target mRNA levels by binding to TOB1 which recruits CNOT7/CAF1 to a ternary complex and this leads to target mRNA deadenylation and decay (By similarity). In addition to its role in translation, binds to and inhibits the transcriptional activation activity of STAT5B without affecting its dimerization or DNA-binding activity. This, in turn, represses transcription of the STAT5B target gene EGFR which has been shown to play a role in enhancing learning and memory performance (By similarity). In contrast to CPEB1, CPEB2 and CPEB4, not required for cell cycle progression (By similarity). {ECO:0000250|UniProtKB:Q8NE35, ECO:0000269|PubMed:17024188, ECO:0000269|PubMed:22153079, ECO:0000269|PubMed:22711986, ECO:0000269|PubMed:24155305, ECO:0000269|PubMed:26074003, ECO:0000269|PubMed:26074071, ECO:0000269|PubMed:26074072, ECO:0000269|PubMed:26915043}.
uniprot
proteins
mass_dalton
78335
uniprot
proteins
mutagenesis
MUTAGEN 419; /note="S->A: Abolishes phosphorylation by PKA."; /evidence="ECO:0000269|PubMed:26915047"; MUTAGEN 420; /note="S->A: Reduces phosphorylation by PKA."; /evidence="ECO:0000269|PubMed:26915047
uniprot
proteins
post_translational_modification
PTM: Activated by NEURL1-mediated monoubiquitination, resulting in the growth of new dendritic spines and increased levels of GRIA1 and GRIA2. NEURL1-mediated monoubiquitination facilitates synaptic plasticity and hippocampal-dependent memory storage. {ECO:0000269|PubMed:22153079}.; PTM: Under basal unstimulated conditions when CPEB3 is mainly unaggregated, sumoylated and acts as a translational repressor. Following neuronal stimulation, becomes desumoylated and aggregated which is required for the translation of mRNA targets and for dendritic filopodia formation. {ECO:0000269|PubMed:26074071}.; PTM: Following neuronal stimulation, cleaved by CAPN2 which abolishes its translational repressor activity, leading to translation of CPEB3 target mRNAs. {ECO:0000269|PubMed:22711986}.; PTM: Phosphorylation is enhanced by neuronal stimulation. {ECO:0000269|PubMed:26915047}.
uniprot
proteins
protein_family
RRM CPEB family
uniprot
proteins
pubmed
12871996
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17024188
uniprot
proteins
pubmed
20003455
uniprot
proteins
pubmed
20639532
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22153079
uniprot
proteins
pubmed
22711986
uniprot
proteins
pubmed
22730302
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24155305
uniprot
proteins
pubmed
26074003
uniprot
proteins
pubmed
26074071
uniprot
proteins
pubmed
26074072
uniprot
proteins
pubmed
26915043
uniprot
proteins
pubmed
26915047
uniprot
proteins
sequence_length
716
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22711986}. Nucleus {ECO:0000269|PubMed:22711986}. Synapse {ECO:0000269|PubMed:17024188}. Cell projection, dendrite {ECO:0000269|PubMed:17024188, ECO:0000269|PubMed:22153079, ECO:0000269|PubMed:22711986}. Postsynaptic density {ECO:0000269|PubMed:17024188}. Note=Predominantly cytoplasmic in unstimulated neurons but translocates to the nucleus following neuronal stimulation (PubMed:22711986). Nuclear import is mediated by importin IPO5 (PubMed:22730302). {ECO:0000269|PubMed:22711986, ECO:0000269|PubMed:22730302}.
uniprot
proteins