KPNA1
entrez
3836
canonical
uniprot
P52294
canonical
ensembl
ENSG00000114030
resolver
ensp
ENSP00000343701
resolver
ensp
ENSP00000581629
resolver
ensp
ENSP00000581630
resolver
ensp
ENSP00000632593
resolver
enst
ENST00000344337
resolver
enst
ENST00000911570
resolver
enst
ENST00000911571
resolver
enst
ENST00000962534
resolver
genesymbol
KPNA1
resolver
genesymbol_syn
RCH2
resolver
hgnc
HGNC:6394
resolver
uniprot
D3DN93
resolver
uniprot
Q6IBQ9
resolver
uniprot
Q9BQ56
resolver
uniprot_entry
IMA5_HUMAN
resolver
uniprot_sec
D3DN93
resolver
uniprot_sec
Q6IBQ9
resolver
uniprot_sec
Q9BQ56
resolver
amino_acid_sequence
MTTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNVATAEEETEEEVMSDGGFHEAQISNMEMAPGGVITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVISTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLENILRLGEQEAKRNGTGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDEDSSIAPQVDLNQQQYIFQQCEAPMEGFQL
uniprot
proteins
function
FUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:27713473, PubMed:7892216, PubMed:8692858). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:27713473, PubMed:7892216, PubMed:8692858). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:27713473, PubMed:7892216). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin (PubMed:7892216). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:7892216). Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA2 and Transportin-1/TNPO1 (PubMed:35446349). {ECO:0000269|PubMed:27713473, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:7892216, ECO:0000269|PubMed:8692858}.; FUNCTION: (Microbial infection) In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. {ECO:0000269|PubMed:12610148}.
uniprot
proteins
mass_dalton
60222
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated in the presence of RAG1 (in vitro). {ECO:0000269|PubMed:19118899}.
uniprot
proteins
protein_family
Importin alpha family
uniprot
proteins
pubmed
10612665
uniprot
proteins
pubmed
12610148
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15942031
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
16698996
uniprot
proteins
pubmed
17652399
uniprot
proteins
pubmed
17928350
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19118899
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21385873
uniprot
proteins
pubmed
21454664
uniprot
proteins
pubmed
22500989
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27713473
uniprot
proteins
pubmed
28552616
uniprot
proteins
pubmed
29599122
uniprot
proteins
pubmed
30576860
uniprot
proteins
pubmed
35446349
uniprot
proteins
pubmed
7604027
uniprot
proteins
pubmed
7831767
uniprot
proteins
pubmed
7892216
uniprot
proteins
pubmed
8052633
uniprot
proteins
pubmed
8692858
uniprot
proteins
pubmed
9463369
uniprot
proteins
sequence_length
538
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:7604027, ECO:0000269|PubMed:7892216}. Nucleus {ECO:0000269|PubMed:7604027, ECO:0000269|PubMed:7892216}.
uniprot
proteins