SLC39A1
entrez
27173
canonical
uniprot
Q9NY26
canonical
ensembl
ENSG00000143570
resolver
ensp
ENSP00000309710
resolver
ensp
ENSP00000348535
resolver
ensp
ENSP00000357610
resolver
ensp
ENSP00000443632
resolver
ensp
ENSP00000479421
resolver
ensp
ENSP00000484182
resolver
enst
ENST00000537590
resolver
genesymbol
SLC39A1
resolver
genesymbol_syn
IRT1
resolver
genesymbol_syn
ZIP1
resolver
genesymbol_syn
ZIRTL
resolver
hgnc
HGNC:12876
resolver
uniprot
A0A0A0MTL8
resolver
uniprot
B4DDY7
resolver
uniprot
Q5T4K1
resolver
uniprot
Q8N2H7
resolver
uniprot
Q9BTV0
resolver
uniprot
Q9UBI7
resolver
uniprot
Q9Y2Z7
resolver
uniprot
Q9Y380
resolver
uniprot_entry
A0A0A0MTL8_HUMAN
resolver
uniprot_entry
S39A1_HUMAN
resolver
uniprot_sec
B4DDY7
resolver
uniprot_sec
Q5T4K1
resolver
uniprot_sec
Q8N2H7
resolver
uniprot_sec
Q9BTV0
resolver
uniprot_sec
Q9UBI7
resolver
uniprot_sec
Q9Y2Z7
resolver
uniprot_sec
Q9Y380
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by Ni(2+) ions. Fe(2+) ions do not inhibit zinc uptake. {ECO:0000269|PubMed:11301334}.
uniprot
proteins
amino_acid_sequence
MGPWGEPELLVWRPEAVASEPPVPVGLEVKLGALVLLLVLTLLCSLVPICVLRRPGANHEGSASRQKALSLVSCFAGGVFLATCLLDLLPDYLAAIDEALAALHVTLQFPLQEFILAMGFFLVLVMEQITLAYKEQSGPSPLEETRALLGTVNGGPQHWHDGPGVPQASGAPATPSALRACVLVFSLALHSVFEGLAVGLQRDRARAMELCLALLLHKGILAVSLSLRLLQSHLRAQVVAGCGILFSCMTPLGIGLGAALAESAGPLHQLAQSVLEGMAAGTFLYITFLEILPQELASSEQRILKVILLLAGFALLTGLLFIQI
uniprot
proteins
function
FUNCTION: Transporter for the divalent cation Zn(2+). Mediates the influx of Zn(2+) into cells from extracellular space (PubMed:11301334, PubMed:12888280, PubMed:16844077). Functions as the major importer of zinc from circulating blood plasma into prostate cells (PubMed:12888280). {ECO:0000269|PubMed:11301334, ECO:0000269|PubMed:12888280, ECO:0000269|PubMed:16844077}.
uniprot
proteins
mass_dalton
34250
uniprot
proteins
mutagenesis
MUTAGEN 158; /note="H->A: Does not affect membrane localization; when associated with A-160. Decreases zinc uptake; when associated with A-160."; /evidence="ECO:0000269|PubMed:16844077"; MUTAGEN 160; /note="H->A: Does not affect membrane localization; when associated with A-158. Decreases zinc uptake; when associated with A-158."; /evidence="ECO:0000269|PubMed:16844077"; MUTAGEN 190; /note="H->A: Does not affect membrane localization. Decreases zinc uptake."; /evidence="ECO:0000269|PubMed:16844077"; MUTAGEN 217; /note="H->A: Does not affect membrane localization. Decreases zinc uptake."; /evidence="ECO:0000269|PubMed:16844077
uniprot
proteins
protein_family
ZIP transporter (TC 2.A.5) family
uniprot
proteins
pubmed
10610721
uniprot
proteins
pubmed
10810093
uniprot
proteins
pubmed
11301334
uniprot
proteins
pubmed
11696349
uniprot
proteins
pubmed
12888280
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16153295
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16844077
uniprot
proteins
pubmed
21269460
uniprot
proteins
sequence_length
324
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11301334, ECO:0000269|PubMed:11696349, ECO:0000269|PubMed:16844077}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:11696349}; Multi-pass membrane protein {ECO:0000255}. Note=Shows a vesicular localization corresponding partially to the endoplasmic reticulum in several epithelial cell lines. {ECO:0000269|PubMed:11696349}.
uniprot
proteins
transmembrane_region
TRANSMEM 31..51; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 69..89; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 105..125; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 180..200; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 207..227; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 238..258; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 273..293; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 304..324; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins