Clca1
entrez
23844
canonical
uniprot
Q9D7Z6
canonical
ensembl
ENSMUSG00000028255
resolver
ensp
ENSMUSP00000029919
resolver
enst
ENSMUST00000029919
resolver
genesymbol
Clca1
resolver
genesymbol_syn
Clca3
resolver
genesymbol_syn
Gob5
resolver
uniprot
O88826
resolver
uniprot
Q8R049
resolver
uniprot_entry
CLCA1_MOUSE
resolver
uniprot_sec
O88826
resolver
uniprot_sec
Q8R049
resolver
amino_acid_sequence
MESLKSPVFLLILHLLEGVLSESLIQLNNNGYEGIVIAIDHDVPEDEALIQHIKDMVTQASPYLFEATGKRFYFKNVAILIPESWKAKPEYTRPKLETFKNADVLVSTTSPLGNDEPYTEHIGACGEKGIRIHLTPDFLAGKKLTQYGPQDRTFVHEWAHFRWGVFNEYNNDEKFYLSKGKPQAVRCSAAITGKNQVRRCQGGSCITNGKCVIDRVTGLYKDNCVFVPDPHQNEKASIMFNQNINSVVEFCTEKNHNQEAPNDQNQRCNLRSTWEVIQESEDFKQTTPMTAQPPAPTFSLLQIGQRIVCLVLDKSGSMLNDDRLNRMNQASRLFLLQTVEQGSWVGMVTFDSAAYVQSELKQLNSGADRDLLIKHLPTVSAGGTSICSGLRTAFTVIKKKYPTDGSEIVLLTDGEDNTISSCFDLVKQSGAIIHTVALGPAAAKELEQLSKMTGGLQTYSSDQVQNNGLVDAFAALSSGNAAIAQHSIQLESRGVNLQNNQWMNGSVIVDSSVGKDTLFLITWTTHPPTIFIWDPSGVEQNGFILDTTTKVAYLQVPGTAKVGFWKYSIQASSQTLTLTVTSRAASATLPPITVTPVVNKNTGKFPSPVTVYASIRQGASPILRASVTALIESVNGKTVTLELLDNGAGADATKNDGVYSRFFTAFDANGRYSVKIWALGGVTSDRQRAAPPKNRAMYIDGWIEDGEVRMNPPRPETSYVQDKQLCFSRTSSGGSFVATNVPAAAPIPDLFPPCQITDLKASIQGQNLVNLTWTAPGDDYDHGRASNYIIRMSTSIVDLRDHFNTSLQVNTTGLIPKEASSEEIFEFELGGNTFGNGTDIFIAIQAVDKSNLKSEISNIARVSVFIPAQEPPIPEDSTPPCPDISINSTIPGIHVLKIMWKWLGEMQVTLGLH
uniprot
proteins
ec_number
3.4.-.-
uniprot
proteins
function
FUNCTION: May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. {ECO:0000269|PubMed:11296262, ECO:0000269|PubMed:11694454, ECO:0000269|PubMed:16645179}.
uniprot
proteins
mass_dalton
100071
uniprot
proteins
post_translational_modification
PTM: The 110 kDa translation product is autoproteolytically cleaved by the metalloprotease domain in the endoplasmic reticulum into a 75 kDa N-terminal and a 35 kDa C-terminal products that remain physically associated with each other. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity. {ECO:0000250|UniProtKB:A8K7I4, ECO:0000269|PubMed:12019299}.; PTM: Glycosylated. {ECO:0000269|PubMed:12019299, ECO:0000269|PubMed:16895902}.
uniprot
proteins
protein_family
CLCR family
uniprot
proteins
pubmed
10049711
uniprot
proteins
pubmed
11296262
uniprot
proteins
pubmed
11694454
uniprot
proteins
pubmed
12019299
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15919655
uniprot
proteins
pubmed
16099848
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16251409
uniprot
proteins
pubmed
16645179
uniprot
proteins
pubmed
16895902
uniprot
proteins
sequence_length
913
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000269|PubMed:12019299, ECO:0000269|PubMed:15919655, ECO:0000269|PubMed:16895902}. Note=The 75 kDa N-terminal and a 35 kDa C-terminal products are fully secreted into extracellular environment as a soluble complex of two glycoproteins.
uniprot
proteins