Tle4
entrez
25565
canonical
uniprot
Q07141
canonical
ensembl
ENSRNOG00000013239
resolver
ensp
ENSRNOP00000018272
resolver
ensp
ENSRNOP00000018452
resolver
ensp
ENSRNOP00000074268
resolver
ensp
ENSRNOP00000092863
resolver
enst
ENSRNOT00000018272
resolver
enst
ENSRNOT00000018452
resolver
enst
ENSRNOT00000119003
resolver
genesymbol
Tle4
resolver
genesymbol_syn
Esp2
resolver
genesymbol_syn
Grg4
resolver
uniprot
A0A8I6AEP9
resolver
uniprot
F1LQJ5
resolver
uniprot
F1M0E7
resolver
uniprot_entry
A0A8I6AEP9_RAT
resolver
uniprot_entry
F1LQJ5_RAT
resolver
uniprot_entry
F1M0E7_RAT
resolver
uniprot_entry
TLE4_RAT
resolver
amino_acid_sequence
MIRDLSKMYRRRAHPAPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNAICAQVIPCLSQEQQQLQAQHLLTWTWSACASDTTPLGFSQPFHPSGSSAGLLALSSALGGQSHLPIKDEKKHHDNDHQRDRDSIKSSSVSPSASFRGSEKHRNSTDYSSESKKQKTEEKEIAARYDSDGEKSDDNLVVDVSNEDPSSPRGSPAHSPRENGLDKTRLLKKDAPISPASVASSSSTPSSKSKELSLNEKSTTPVSKSNTPTPRTDAPTPGSNSTPGLRPVPGKPPGVDPLASSLRTPMAVPCPYPTPFGIVPHAGMNGELTSPGAAYAGLHNISPQMSAAAAAAAAAAAYGRSPVVGFDPHHHMRVPAIPPNLTGIPGGKPAYSFHVSADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDITDPGNKSPVSQLDCLNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMENSNVEVLHVTKPDKYQLHLHESCVLSLKFAHCGKWFVRPGKDNLLNAWRTPYGASIFQSKESSSVLSCDISADDKYIVTGSGDKKATVYEVIY
uniprot
proteins
function
FUNCTION: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity). Involved in transcriptional repression of GNRHR and enhances MSX1-mediated transcriptional repression of CGA/alpha-GSU (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q62441}.
uniprot
proteins
mass_dalton
81334
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. PAX5 binding increases phosphorylation. {ECO:0000250|UniProtKB:Q62441}.; PTM: Ubiquitinated by XIAP/BIRC4. {ECO:0000250}.
uniprot
proteins
protein_family
WD repeat Groucho/TLE family
uniprot
proteins
pubmed
18254933
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8245004
uniprot
proteins
sequence_length
748
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins