Cplane2
entrez
76166
canonical
uniprot
A2A825
canonical
ensembl
ENSMUSG00000073733
resolver
ensp
ENSMUSP00000095422
resolver
enst
ENSMUST00000097813
resolver
genesymbol
Cplane2
resolver
genesymbol_syn
6330545A04Rik
resolver
genesymbol_syn
Gm723
resolver
genesymbol_syn
Rsg1
resolver
uniprot
B2RWG6
resolver
uniprot_entry
B2RWG6_MOUSE
resolver
uniprot_entry
CPLN2_MOUSE
resolver
amino_acid_sequence
MARPPMHGSVIVPDWHETVEGKEYLACILRKNRRREFGLLERPVLPPSVVIDTASYKIFVSGKSGVGKTALVAKLAGLEVPIVHHETTGIQTTVVFWPAKLKASDCVVMFRFEFWDCGESALKKFDHMLPACKENADAFLFLFSFTDRASFEDLPGQLTRVAGEAPGLVKIVIGSKFDQYMHTDVPARDLTAFRQAWELPLFRVKSVPGRRLADGRTLDGRAGLADTAHVLNGLAEQLWHQDQVAAGLLPSSPESAPG
uniprot
proteins
function
FUNCTION: Required for efficient primary cilia initiation, regulating a late step in cilia initiation. Plays a role in the final maturation of the mother centriole and ciliary vesicle that allows extension of the ciliary axoneme. {ECO:0000269|PubMed:29038301}.
uniprot
proteins
mass_dalton
28422
uniprot
proteins
mutagenesis
MUTAGEN 69; /note="T->N: Loss of localization to the cilium basal body."; /evidence="ECO:0000269|PubMed:29038301"; MUTAGEN 169; /note="V->D: In pxb (pixiebob phenotype); embryos show ciliopathy-like syndrome of defects that include polydactyly, loss of ventral neural cell types, craniofacial defects, and heart defects that are likely to be responsible for death before E12.5 of gestation. Mutant embryos have fewer primary cilia than wild-type embryos, but the cilia that form are of normal length and traffic Hedgehog pathway proteins within the cilium correctly. Although the early steps of cilia initiation proceed normally in mutant cells, mother centrioles fail to extend the microtubule axoneme and fail to move the ciliary vesicle to the cell surface efficiently. No effect on its localization to the cilium basal body or its interaction with FUZ."; /evidence="ECO:0000269|PubMed:29038301, ECO:0000269|PubMed:35427153
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
29038301
uniprot
proteins
pubmed
35427153
uniprot
proteins
sequence_length
258
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:29038301}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:29038301}. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. Recruitment to the centriole depends on TTBK2, INTU, and its own GTPase activity. {ECO:0000269|PubMed:29038301}.
uniprot
proteins