Trim35
entrez
66854
canonical
uniprot
Q8C006
canonical
ensembl
ENSMUSG00000022043
resolver
ensp
ENSMUSP00000022623
resolver
enst
ENSMUST00000022623
resolver
genesymbol
Trim35
resolver
genesymbol_syn
Hls5
resolver
genesymbol_syn
Kiaa1098
resolver
genesymbol_syn
Mair
resolver
uniprot
A0A0R4J031
resolver
uniprot
A6H681
resolver
uniprot
Q6ZPY0
resolver
uniprot
Q7TQL7
resolver
uniprot
Q810V7
resolver
uniprot
Q8BVY9
resolver
uniprot
Q8VID4
resolver
uniprot
Q9CW74
resolver
uniprot
Q9D208
resolver
uniprot_entry
A0A0R4J031_MOUSE
resolver
uniprot_entry
TRI35_MOUSE
resolver
uniprot_sec
A6H681
resolver
uniprot_sec
Q6ZPY0
resolver
uniprot_sec
Q7TQL7
resolver
uniprot_sec
Q810V7
resolver
uniprot_sec
Q8BVY9
resolver
uniprot_sec
Q8VID4
resolver
uniprot_sec
Q9CW74
resolver
uniprot_sec
Q9D208
resolver
amino_acid_sequence
MEPGPSVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRRCVSGCWEVQTTPSCPVCKERAVPGELRTNHTLNNLVETLLREEAEGARWTGRRSPRPCRAHRAPLTLFCLEDKELLCCACQADARHQEHRVQPIKDTAQDFRAKCKNMEHVLREKAKAFWALRRTYEAIAKHNEVQTTWLEGRIRDEFDKLRDFLRVEEQATLDAMKEESRKKHLQAEEKMKQLAEQTEALAREIERLQMEMKEDDMTFLMKHKSRKRRLFCTVEPAPLQPGLLMDACKYLESLQYRVWKKMLGSVESVPFSLDPNTAAGWLKVADDLTSVINHGYRVQVENPERFSSAPCLLGSQVFSKGSHSWEVDVGGLPTWRVGVVRVQAHAQAQAQADVGGEGHSHSCYHDTRSGFWYLCRTQGVDGDHCMTSDTATAPLVQAMPRRLRVELECEEGELSFYDSERHCHLYTFHAHFGEVRPYFYLGASRGDGPPEPLRICHLRVSIKEELDI
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that participates in multiple biological processes including cell death, glucose metabolism, and in particular, the innate immune response (By similarity) (PubMed:32562145). Mediates 'Lys-63'-linked polyubiquitination of TRAF3 thereby promoting type I interferon production via RIG-I signaling pathway. Can also catalyze 'Lys-48'-linked polyubiquitination and proteasomal degradation of viral proteins such as influenza virus PB2. Acts as a negative feedback regulator of TLR7- and TLR9-triggered signaling. Mechanistically, promotes the 'Lys-48'-linked ubiquitination of IRF7 and induces its degradation via a proteasome-dependent pathway. Reduces FGFR1-dependent tyrosine phosphorylation of PKM, inhibiting PKM-dependent lactate production, glucose metabolism, and cell growth (By similarity). {ECO:0000250|UniProtKB:Q9UPQ4, ECO:0000269|PubMed:32562145}.
uniprot
proteins
mass_dalton
57345
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
12692137
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
14662771
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
32562145
uniprot
proteins
sequence_length
501
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12692137}. Nucleus. Note=Found predominantly in cytoplasm with a granular distribution. Found in punctuate nuclear bodies in transfected COS and HeLa cells. {ECO:0000269|PubMed:12692137}.
uniprot
proteins