Ccdc88a
entrez
108686
canonical
uniprot
Q5SNZ0
canonical
ensembl
ENSMUSG00000032740
resolver
ensp
ENSMUSP00000048978
resolver
ensp
ENSMUSP00000159356
resolver
ensp
ENSMUSP00000297223
resolver
ensp
ENSMUSP00000297224
resolver
ensp
ENSMUSP00000297225
resolver
ensp
ENSMUSP00000297226
resolver
ensp
ENSMUSP00000297227
resolver
ensp
ENSMUSP00000342647
resolver
enst
ENSMUST00000239407
resolver
genesymbol
Ccdc88a
resolver
genesymbol_syn
Grdn
resolver
genesymbol_syn
Kiaa1212
resolver
uniprot
A0A6I8MX08
resolver
uniprot
Q5M6X2
resolver
uniprot
Q5M6X4
resolver
uniprot
Q5M6X5
resolver
uniprot
Q5SNZ1
resolver
uniprot
Q8C486
resolver
uniprot
Q8CFU7
resolver
uniprot_entry
A0A6I8MX08_MOUSE
resolver
uniprot_entry
GRDN_MOUSE
resolver
uniprot_sec
Q5M6X2
resolver
uniprot_sec
Q5M6X4
resolver
uniprot_sec
Q5M6X5
resolver
uniprot_sec
Q5SNZ1
resolver
uniprot_sec
Q8C486
resolver
uniprot_sec
Q8CFU7
resolver
amino_acid_sequence
MENEIFTPLLEQFMTSPLVTWVKTFGPLAAGNGTNLDEYVALVDGVFLNQVMLQINPKSESQRVNKKVNNDASLRIHNLSILVKQIKFYYQETLQQLIMMPLPDILIIGKNPFSEQGTEEVKKLLLLLLGCAVQCQKKEEFIEKIQGLDFDTKAAVAAHIQEVTHNQENVFDLQWMEVTDMSQEDIEPLLKNMVSHLRRLIDERDEHSETIVELSEERDGVHFLPHASSSAQSPCGSPGMKRTESRQHLSVELADAKAKIRRLRQELEEKTEQLLDCKQELEQIEVELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESELSRYKERLHDIEFYKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELAEAPQKSLGHEVNELTSSKLLKLEMENQSLTKTVEELRSTADSAAGSTSKILKVEKENQRLNKKVEILENEIIQEKQSLQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEARVKDIEKENKILHESIKETCGKLSKIEFEKRQMKKELELYKEKGERAEELENELNHLGKENELLQKKITNLKITCEKLETLEQENSELERENRKFKKTLDSFKNLTFQLESLEKENSQLDEENLELRRSVESLKCASMRMAQLQLENKELESEKEQLRKGLELMRASFKKTERLEVSYQGLDTENQRLQKALENSNKKIQQLESELQDLEMENQTLQKSLEELKISSKRLEQLEKENKSLEQETSQLEKDKKQLEKENKRLRQQAEIKDTTLEENNVKIGNLEKENKTLFKEINVYKESCVRLKELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRHELKTVKKNYEALKQRQDEERMVQSSIPVSGEDDKWGRESQEATRELLKVKDRLIEVERNNATLQAEKQALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLENENESIMKEREDLKSLYDALIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHKDLEDRYNQLLKQKGQLEDLEKMIKTEQEKMLLESKNHEVVASEYKKLCGENDRLNYTYSQLLKETEILQMDHKNLKSVLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDLFHVEQRQYIDKLNELRRQKEKLEEKIMDQYKFYDPSPPRRRGNWITLKMRKLIKSKKDINRERQKSLTLTPTRSDSSEGFLQLPHQDSQDSSSVGSNSLEDGQTLGTKKSSMVALKRLPFLRNRPKDKDKMKACYRRSMSMNDLVQSMVLAGGQWTGSTENLEVPDDISTGKRRKELGAMAFSTTAINFSTVNSSAAFRSKQLVNNKDTTSFEDISPQGISDDSSTGSRVHASRPASLDSGRTSTSNSNNNASLHEVKAGAVNIQSRPQSHSSGDFSLLHDHETWSSSGSSPIQYLKRQTRSSPMLQHKISETIESRAHHKMKAGSPGSEVVTLQQFLEESNKLTSIQLKSSSQENLLDEVMKSLSVSSDFLGKDKPVSCTLARSVSGKTPGDFYDRRTTKPEFLRTGPQKTEDAYTISSAGKPTPSTQGKIKLVKETSVSRQSKDSNPYATLPRASSVISTAEGTTRRTSIHDFLSKDSRLPVSVDSSPPTAGSSSTTASNVNKVQESRNSKSRSREQQSS
uniprot
proteins
function
FUNCTION: Bifunctional modulator of guanine nucleotide-binding proteins (G proteins) (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein G(i) alpha subunits (By similarity). Also acts as a guanine nucleotide dissociation inhibitor for guanine nucleotide-binding protein G(s) subunit alpha GNAS (By similarity). Essential for cell migration (By similarity). Interacts in complex with G(i) alpha subunits with the EGFR receptor, retaining EGFR at the cell membrane following ligand stimulation and promoting EGFR signaling which triggers cell migration (By similarity). Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G protein complex which enhances phosphoinositide 3-kinase (PI3K)-dependent phosphorylation and kinase activity of AKT1/PKB (By similarity). Phosphorylation of AKT1/PKB induces the phosphorylation of downstream effectors GSK3 and FOXO1/FKHR, and regulates DNA replication and cell proliferation (PubMed:15753085). Binds in its tyrosine-phosphorylated form to the phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1 which enables recruitment of PIK3R1 to the EGFR receptor, enhancing PI3K activity and cell migration (By similarity). Plays a role as a key modulator of the AKT-mTOR signaling pathway, controlling the tempo of the process of newborn neuron integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (PubMed:19778506). Inhibition of G(s) subunit alpha GNAS leads to reduced cellular levels of cAMP and suppression of cell proliferation (By similarity). Essential for the integrity of the actin cytoskeleton (By similarity). Required for formation of actin stress fibers and lamellipodia (By similarity). May be involved in membrane sorting in the early endosome (By similarity). Plays a role in ciliogenesis and cilium morphology and positioning and this may partly be through regulation of the localization of scaffolding protein CROCC/Rootletin (By similarity). {ECO:0000250|UniProtKB:Q3V6T2, ECO:0000269|PubMed:15753085, ECO:0000269|PubMed:19778506}.
uniprot
proteins
mass_dalton
215918
uniprot
proteins
post_translational_modification
PTM: Phosphorylation is induced by epidermal growth factor (EGF) in a phosphoinositide 3-kinase (PI3K)-dependent manner (By similarity). Phosphorylation by AKT1/PKB is necessary for the delocalization from the cell membrane and for cell migration (By similarity). Phosphorylated on tyrosine residues which promotes binding to phosphatidylinositol 3-kinase (PI3K) regulatory subunit PIK3R1/p85a and enhances PI3K activity (By similarity). Tyrosine-phosphorylated by both receptor and non-receptor tyrosine kinases in vitro (By similarity). Tyrosine phosphorylation is required for AKT1-dependent phosphorylation of Ser-1417 (By similarity). Phosphorylation at Ser-1692 by PRKCQ disrupts interaction with GNAI3 and inhibits guanine nucleotide exchange factor activity (By similarity). {ECO:0000250|UniProtKB:Q3V6T2}.
uniprot
proteins
protein_family
CCDC88 family
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15753085
uniprot
proteins
pubmed
15882442
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17185515
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19778506
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26917597
uniprot
proteins
sequence_length
1873
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q3V6T2}; Peripheral membrane protein {ECO:0000305}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q3V6T2}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q3V6T2}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q3V6T2}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q3V6T2}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q3V6T2}. Note=Localizes to the cytosol in unstimulated cells while EGF stimulation promotes membrane localization and guanine nucleotide exchange factor activity (By similarity). Localizes to the cell membrane through interaction with phosphoinositides (By similarity). {ECO:0000250|UniProtKB:Q3V6T2}.
uniprot
proteins