PMEPA1
entrez
56937
canonical
uniprot
Q969W9
canonical
ensembl
ENSG00000124225
resolver
ensp
ENSP00000265626
resolver
ensp
ENSP00000344014
resolver
ensp
ENSP00000345826
resolver
ensp
ENSP00000379161
resolver
ensp
ENSP00000401506
resolver
genesymbol
PMEPA1
resolver
genesymbol
TMEPAI
resolver
genesymbol_syn
STAG1
resolver
genesymbol_syn
TMEPAI
resolver
hgnc
HGNC:14107
resolver
uniprot
Q5JY37
resolver
uniprot
Q5TDR6
resolver
uniprot
Q8NER4
resolver
uniprot
Q96B72
resolver
uniprot
Q9UJD3
resolver
uniprot_entry
PMEPA_HUMAN
resolver
uniprot_entry
Q5JY37_HUMAN
resolver
uniprot_sec
Q5TDR6
resolver
uniprot_sec
Q8NER4
resolver
uniprot_sec
Q96B72
resolver
uniprot_sec
Q9UJD3
resolver
amino_acid_sequence
MHRLMGVNSTAAAAAGQPNVSCTCNCKRSLFQSMEITELEFVQIIIIVVVMMVMVVVITCLLSHYKLSARSFISRHSQGRRREDALSSEGCLWPSESTVSGNGIPEPQVYAPPRPTDRLAVPPFAQRERFHRFQPTYPYLQHEIDLPPTISLSDGEEPPPYQGPCTLQLRDPEQQLELNRESVRAPPNRTIFDSDLMDSARLGGPCPPSSNSGISATCYGSGGRMEGPPPTYSEVIGHYPGSSFQHQQSSGPPSLLEGTRLHHTHIAPLESAAIWSKEKDKQKGHPL
uniprot
proteins
function
FUNCTION: Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal (PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor (AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4 (PubMed:18703514). {ECO:0000269|PubMed:18703514, ECO:0000269|PubMed:20129061, ECO:0000269|PubMed:24627487}.
uniprot
proteins
mass_dalton
31609
uniprot
proteins
mutagenesis
MUTAGEN 161; /note="Y->A: Impairs interaction with NEDD4. Impairs polyubiquitination of AR; when associated with A-232."; /evidence="ECO:0000269|PubMed:12907594, ECO:0000269|PubMed:18703514"; MUTAGEN 232; /note="Y->A: Impairs interaction with NEDD4. Impairs polyubiquitination of AR; when associated with A-232."; /evidence="ECO:0000269|PubMed:12907594, ECO:0000269|PubMed:18703514
uniprot
proteins
protein_family
PMEPA1 family
uniprot
proteins
pubmed
10873380
uniprot
proteins
pubmed
11568975
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12670906
uniprot
proteins
pubmed
12907594
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18703514
uniprot
proteins
pubmed
20129061
uniprot
proteins
pubmed
24627487
uniprot
proteins
sequence_length
287
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 41..63; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins