Klhdc1
entrez
271005
canonical
uniprot
Q80YG3
canonical
ensembl
ENSMUSG00000051890
resolver
ensp
ENSMUSP00000068046
resolver
ensp
ENSMUSP00000286665
resolver
enst
ENSMUST00000063445
resolver
genesymbol
Klhdc1
resolver
uniprot
Q0VDQ7
resolver
uniprot_entry
KLDC1_MOUSE
resolver
uniprot_sec
Q0VDQ7
resolver
amino_acid_sequence
MADPQAFCVAEERSGHCAVVDGHFLYVWGGYVSIEDNEVYLPNDEMWTYDIDSGLWKMHLMEGELPPSMSGSCGACIHGRLYVFGGYDDKGYSNRLYFVNLRTRDGTYTWEKITKFDGQPPTPRDKLSCWVYKDRLIYFGGYGYRRHSELQECFDVHDASWEEQIFWGWHNDVHVFDTKTRTWSQPEIKGGVPPQPRAAHSCAVLGNKGYVFGGRVLQTRMNDLHYLNLDTWVWSGRISVNGESPKHRSWHTLTAITDDKLFLFGGLNADNIPLSDGWIHNITTNCWKQLRHLPYTRPRLWHTACLGKENEIMVFGGSKDNLLFLDTGHCNDLLIFQTQPYSLLRSCLDCIGKNAIILKSQISLLPPKLLQQVLKKITFWTAANYRKEQRIRKEETENNQPRVSSC
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a Cul5-RING (CRL5) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms. The CRL5(KLHDC1) complex mediates ubiquitination and degradation of truncated SELENOS selenoprotein produced by failed UGA/Sec decoding, which ends with a glycine. {ECO:0000250|UniProtKB:Q8N7A1}.
uniprot
proteins
mass_dalton
46830
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q8N7A1}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
406
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8N7A1}.
uniprot
proteins