TIRAP
entrez
114609
canonical
uniprot
P58753
canonical
ensembl
ENSG00000150455
resolver
ensp
ENSP00000376445
resolver
ensp
ENSP00000376446
resolver
ensp
ENSP00000376447
resolver
ensp
ENSP00000515019
resolver
genesymbol
TIRAP
resolver
genesymbol_syn
MAL
resolver
hgnc
HGNC:17192
resolver
uniprot
B3KW65
resolver
uniprot
Q56UH9
resolver
uniprot
Q56UI0
resolver
uniprot
Q8N5E5
resolver
uniprot_entry
TIRAP_HUMAN
resolver
uniprot_sec
B3KW65
resolver
uniprot_sec
Q56UH9
resolver
uniprot_sec
Q56UI0
resolver
uniprot_sec
Q8N5E5
resolver
amino_acid_sequence
MASSTSLPAPGSRPKKPLGKMADWFRQTLLKKPKKRPNSPESTSSDASQPTSQDSPLPPSLSSVTSPSLPPTHASDSGSSRWSKDYDVCVCHSEEDLVAAQDLVSYLEGSTASLRCFLQLRDATPGGAIVSELCQALSSSHCRVLLITPGFLQDPWCKYQMLQALTEAPGAEGCTIPLLSGLSRAAYPPELRFMYYVDGRGPDGGFRQVKEAVMRYLQTLS
uniprot
proteins
function
FUNCTION: Adapter involved in TLR2, TLR4 and RAGE signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF (TNF) and interleukin-6 (IL6). {ECO:0000269|PubMed:18292575, ECO:0000269|PubMed:19509286, ECO:0000269|PubMed:21829704}.
uniprot
proteins
mass_dalton
23883
uniprot
proteins
mutagenesis
MUTAGEN 125; /note="P->H: Abolishes NF-kappa-B activation."; /evidence="ECO:0000269|PubMed:11526399, ECO:0000269|PubMed:11544529
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by IRAK1 and IRAK4. Also phosphorylated by BTK.; PTM: Polyubiquitinated. Polyubiquitination follows phosphorylation by BTK and leads to TIRAP degradation. {ECO:0000269|PubMed:16415872}.
uniprot
proteins
pubmed
11526399
uniprot
proteins
pubmed
11544529
uniprot
proteins
pubmed
14530355
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16415872
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17322885
uniprot
proteins
pubmed
18292575
uniprot
proteins
pubmed
18305471
uniprot
proteins
pubmed
18810425
uniprot
proteins
pubmed
19509286
uniprot
proteins
pubmed
19602285
uniprot
proteins
pubmed
19948740
uniprot
proteins
pubmed
20400509
uniprot
proteins
pubmed
21829704
uniprot
proteins
pubmed
21873236
uniprot
proteins
pubmed
24265315
uniprot
proteins
pubmed
24275656
uniprot
proteins
pubmed
27311859
uniprot
proteins
sequence_length
221
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19948740}. Cell membrane {ECO:0000269|PubMed:19948740}. Membrane {ECO:0000269|PubMed:19948740}. Note=Colocalizes with DAB2IP at the plasma membrane.
uniprot
proteins