ADCK1
entrez
57143
canonical
uniprot
Q86TW2
canonical
ensembl
ENSG00000063761
resolver
ensp
ENSP00000238561
resolver
ensp
ENSP00000339663
resolver
ensp
ENSP00000548238
resolver
ensp
ENSP00000548240
resolver
ensp
ENSP00000606880
resolver
ensp
ENSP00000606882
resolver
ensp
ENSP00000621934
resolver
genesymbol
ADCK1
resolver
hgnc
HGNC:19038
resolver
uniprot
B3KUD5
resolver
uniprot
Q6PD65
resolver
uniprot
Q9UIE6
resolver
uniprot_entry
ADCK1_HUMAN
resolver
uniprot_sec
B3KUD5
resolver
uniprot_sec
Q6PD65
resolver
uniprot_sec
Q9UIE6
resolver
amino_acid_sequence
MARKALKLASWTSMALAASGIYFYSNKYLDPNDFGAVRVGRAVATTAVISYDYLTSLKSVPYGSEEYLQLRSKSWPVFLQVHLRSARRLCELCCANRGTFIKVGQHLGALDYLLPEEYTSTLKVLHSQAPQSSMQEIRQVIREDLGKEIHDLFQSFDDTPLGTASLAQVHKAVLHDGRTVAVKVQHPKVRAQSSKDILLMEVLVLAVKQLFPEFEFMWLVDEAKKNLPLELDFLNEGRNAEKVSQMLRHFDFLKVPRIHWDLSTERVLLMEFVDGGQVNDRDYMERNKIDVNEISRHLGKMYSEMIFVNGFVHCDPHPGNVLVRKHPGTGKAEIVLLDHGLYQMLTEEFRLNYCHLWQSLIWTDMKRVKEYSQRLGAGDLYPLFACMLTARSWDSVNRGISQAPVTATEDLEIRNNAANYLPQISHLLNHVPRQMLLILKTNDLLRGIEAALGTRASASSFLNMSRCCIRALAEHKKKNTCSFFRRTQISFSEAFNLWQINLHELILRVKGLKLADRVLALICWLFPAPL
uniprot
proteins
ec_number
2.7.-.-
uniprot
proteins
function
FUNCTION: Appears to be essential for maintaining mitochondrial cristae formation and mitochondrial function by acting via YME1L1 in a kinase-independent manner to regulate essential mitochondrial structural proteins OPA1 and IMMT (PubMed:31125351). The action of this enzyme is not yet clear (Probable). It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr) (Probable). {ECO:0000269|PubMed:31125351, ECO:0000305}.
uniprot
proteins
mass_dalton
60577
uniprot
proteins
mutagenesis
MUTAGEN 164; /note="A->G: No effect on role in maintaining mitochondrial structure and function."; /evidence="ECO:0000269|PubMed:31125351"; MUTAGEN 183; /note="K->I: No effect on role in maintaining mitochondrial structure and function."; /evidence="ECO:0000269|PubMed:31125351"; MUTAGEN 315; /note="D->A: No effect on role in maintaining mitochondrial structure and function."; /evidence="ECO:0000269|PubMed:31125351
uniprot
proteins
protein_family
ADCK protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
31125351
uniprot
proteins
pubmed
33988507
uniprot
proteins
sequence_length
530
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:33988507}.
uniprot
proteins