FZD9
entrez
8326
canonical
uniprot
O00144
canonical
ensembl
ENSG00000188763
resolver
ensp
ENSP00000345785
resolver
enst
ENST00000344575
resolver
genesymbol
FZD9
resolver
genesymbol_syn
FZD3
resolver
hgnc
HGNC:4047
resolver
uniprot_entry
FZD9_HUMAN
resolver
amino_acid_sequence
MAVAPLRGALLLWQLLAAGGAALEIGRFDPERGRGAAPCQAVEIPMCRGIGYNLTRMPNLLGHTSQGEAAAELAEFAPLVQYGCHSHLRFFLCSLYAPMCTDQVSTPIPACRPMCEQARLRCAPIMEQFNFGWPDSLDCARLPTRNDPHALCMEAPENATAGPAEPHKGLGMLPVAPRPARPPGDLGPGAGGSGTCENPEKFQYVEKSRSCAPRCGPGVEVFWSRRDKDFALVWMAVWSALCFFSTAFTVLTFLLEPHRFQYPERPIIFLSMCYNVYSLAFLIRAVAGAQSVACDQEAGALYVIQEGLENTGCTLVFLLLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEAHGSYFHMAAWGLPALKTIVILTLRKVAGDELTGLCYVASTDAAALTGFVLVPLSGYLVLGSSFLLTGFVALFHIRKIMKTGGTNTEKLEKLMVKIGVFSILYTVPATCVIVCYVYERLNMDFWRLRATEQPCAAAAGPGGRRDCSLPGGSVPTVAVFMLKIFMSLVVGITSGVWVWSSKTFQTWQSLCYRKIAAGRARAKACRAPGSYGRGTHCHYKAPTVVLHMTKTDPSLENPTHL
uniprot
proteins
function
FUNCTION: Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (By similarity). May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process (PubMed:27509850). During hippocampal development, regulates neuroblast proliferation and apoptotic cell death. Controls bone formation through non canonical Wnt signaling mediated via ISG15. Positively regulates bone regeneration through non canonical Wnt signaling (By similarity). {ECO:0000250|UniProtKB:Q8K4C8, ECO:0000250|UniProtKB:Q9R216, ECO:0000269|PubMed:27509850}.
uniprot
proteins
mass_dalton
64466
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. {ECO:0000250}.
uniprot
proteins
protein_family
G protein-coupled receptor Fz/Smo family
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
27509850
uniprot
proteins
pubmed
9147651
uniprot
proteins
pubmed
9707618
uniprot
proteins
sequence_length
591
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9R216}; Multi-pass membrane protein {ECO:0000255}. Note=Relocalizes DVL1 to the cell membrane leading to phosphorylation of DVL1 and AXIN1 relocalization to the cell membrane. {ECO:0000250|UniProtKB:Q8K4C8}.
uniprot
proteins
transmembrane_region
TRANSMEM 230..250; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 267..287; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 316..336; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 356..376; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 401..421; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 448..468; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 509..529; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins