CMBL
entrez
134147
canonical
uniprot
Q96DG6
canonical
ensembl
ENSG00000164237
resolver
ensp
ENSP00000296658
resolver
ensp
ENSP00000543598
resolver
ensp
ENSP00000543599
resolver
ensp
ENSP00000543601
resolver
ensp
ENSP00000543602
resolver
ensp
ENSP00000543604
resolver
ensp
ENSP00000543605
resolver
ensp
ENSP00000543609
resolver
ensp
ENSP00000543610
resolver
ensp
ENSP00000543611
resolver
ensp
ENSP00000543612
resolver
ensp
ENSP00000543613
resolver
ensp
ENSP00000543615
resolver
enst
ENST00000296658
resolver
enst
ENST00000873539
resolver
enst
ENST00000873540
resolver
enst
ENST00000873542
resolver
enst
ENST00000873543
resolver
enst
ENST00000873545
resolver
enst
ENST00000873546
resolver
enst
ENST00000873550
resolver
enst
ENST00000873551
resolver
enst
ENST00000873552
resolver
enst
ENST00000873553
resolver
enst
ENST00000873554
resolver
enst
ENST00000873556
resolver
genesymbol
CMBL
resolver
hgnc
HGNC:25090
resolver
uniprot
D3DTC7
resolver
uniprot
Q8TED6
resolver
uniprot_entry
CMBL_HUMAN
resolver
uniprot_sec
D3DTC7
resolver
uniprot_sec
Q8TED6
resolver
activity_regulation
ACTIVITY REGULATION: Strongly inhibited by p-chloromercuribenzoate (PCMB). Partially inhibited by bis-p-nitrophenylphosphate (BNPP). Not inhibited by DFP, PMSF, eserine or EDTA. {ECO:0000269|PubMed:20177059}.
uniprot
proteins
amino_acid_sequence
MANEAYPCPCDIGHRLEYGGLGREVQVEHIKAYVTKSPVDAGKAVIVIQDIFGWQLPNTRYIADMISGNGYTTIVPDFFVGQEPWDPSGDWSIFPEWLKTRNAQKIDREISAILKYLKQQCHAQKIGIVGFCWGGTAVHHLMMKYSEFRAGVSVYGIVKDSEDIYNLKNPTLFIFAENDVVIPLKDVSLLTQKLKEHCKVEYQIKTFSGQTHGFVHRKREDCSPADKPYIDEARRNLIEWLNKYM
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: Cysteine hydrolase whose endogenous substrates and physiological function are unknown. Catalyzes the hydrolytic activation of several ester-based prodrugs, by cleaving the dioxolone ring to yield their respective active metabolites, diacetyl and CO2. Can thus convert the prodrugs Olmesartan medoxomil and Azilsartan medoxomil into their active metabolites (Olmesartan and Azilsartan), two angiotensin receptor blockers. Is also able to activate beta-lactam antibiotics Faropenem medoxomil and Lenampicillin. {ECO:0000269|PubMed:20177059, ECO:0000269|PubMed:23946449}.
uniprot
proteins
mass_dalton
28048
uniprot
proteins
mutagenesis
MUTAGEN 132; /note="C->A: 97% inhibition of enzymatic activity."; /evidence="ECO:0000269|PubMed:20177059"; MUTAGEN 132; /note="C->S: 70% inhibition of enzymatic activity."; /evidence="ECO:0000269|PubMed:20177059
uniprot
proteins
protein_family
Dienelactone hydrolase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20177059
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23946449
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
245
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:20177059, ECO:0000269|PubMed:23946449}.
uniprot
proteins