Chlsn
entrez
73212
canonical
uniprot
Q9CXL3
canonical
ensembl
ENSMUSG00000053553
resolver
ensp
ENSMUSP00000069230
resolver
enst
ENSMUST00000066052
resolver
genesymbol
Chlsn
resolver
genesymbol_syn
3110082I17Rik
resolver
uniprot
G5E8F7
resolver
uniprot
Q6PDQ0
resolver
uniprot_entry
CHOLN_MOUSE
resolver
uniprot_sec
G5E8F7
resolver
uniprot_sec
Q6PDQ0
resolver
amino_acid_sequence
MAKHKRKGLEGTGKESKRQKITPAEETPRTSEAGPDKETASTLVQEASPELSPEERRVLERKLKKERKKEEKKRLREAGIAATQTAKVQTLPAKPSAATLALEYLQGWAQKQESWRFQKTRQTWLLLHMYDEDKVPDEHFPTLLDYLEGLRGSARELTVRKAEALMQKLDEAEPEDSGGSPGKVQRLRQVLQLLS
uniprot
proteins
function
FUNCTION: Hormone secreted from the intestine in response to cholesterol, where it acts to inhibit cholesterol synthesis in the liver and VLDL secretion,leading to a reduction in circulating cholesterol levels. Acts through binding to its receptor, GPR146. {ECO:0000269|PubMed:38503280}.
uniprot
proteins
mass_dalton
22168
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
38503280
uniprot
proteins
sequence_length
195
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:38503280}. Note=Secretion is induced by feeding and cholesterol absorption. {ECO:0000269|PubMed:38503280}.
uniprot
proteins