F11r
entrez
116479
canonical
uniprot
Q9JHY1
canonical
ensembl
ENSRNOG00000004414
resolver
ensp
ENSRNOP00000006141
resolver
enst
ENSRNOT00000006141
resolver
genesymbol
F11r
resolver
genesymbol_syn
Jam1
resolver
uniprot_entry
JAM1_RAT
resolver
amino_acid_sequence
MGTEGKAGSKLLFLFTSMILGSLVQGKGSVYSPQTAVQVPENDSVKLPCIYSGFSSPRVEWKFVQGSTTALVCYNNQITVPYADRVTFSSSGITFSSVTRKDNGEYTCMVSEDGGQNYGEVSIHLTVLVPPSKPTVSIPSSVTIGNRAVLTCSEHDGSPPSEYSWFKDGVPMLTADAKKTRAFINSSYTIDPKSGDLVFDPVSAFDSGEYYCEAQNGYGTAMRSEAVRMEAVELNVGGIVAAVLVTLILLGLLIFGIWFAYSRGYFERTKKGTAPGKKVIYSQPSARSEGEFKQTSSFLV
uniprot
proteins
function
FUNCTION: Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly. Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Ligand for integrin alpha-L/beta-2 involved in memory T-cell and neutrophil transmigration. {ECO:0000250|UniProtKB:O88792, ECO:0000250|UniProtKB:Q9Y624}.
uniprot
proteins
mass_dalton
32370
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250}.
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
300
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250|UniProtKB:Q9Y624}. Cell membrane {ECO:0000250|UniProtKB:Q9Y624}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9Y624}. Note=Localized at tight junctions of both epithelial and endothelial cells. {ECO:0000250|UniProtKB:Q9Y624}.
uniprot
proteins
transmembrane_region
TRANSMEM 239..259; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins