MTDH
entrez
92140
canonical
uniprot
Q86UE4
canonical
ensembl
ENSG00000147649
resolver
ensp
ENSP00000338235
resolver
ensp
ENSP00000428168
resolver
ensp
ENSP00000557833
resolver
ensp
ENSP00000557834
resolver
ensp
ENSP00000585650
resolver
ensp
ENSP00000623249
resolver
ensp
ENSP00000623251
resolver
ensp
ENSP00000623252
resolver
ensp
ENSP00000695872
resolver
enst
ENST00000336273
resolver
genesymbol
MTDH
resolver
genesymbol_syn
AEG1
resolver
genesymbol_syn
LYRIC
resolver
hgnc
HGNC:29608
resolver
uniprot
Q05DH2
resolver
uniprot
Q52QU9
resolver
uniprot
Q6PK07
resolver
uniprot
Q8TCX3
resolver
uniprot_entry
LYRIC_HUMAN
resolver
uniprot_sec
Q05DH2
resolver
uniprot_sec
Q52QU9
resolver
uniprot_sec
Q6PK07
resolver
uniprot_sec
Q8TCX3
resolver
amino_acid_sequence
MAARSWQDELAQQAEEGSARLREMLSVGLGFLRTELGLDLGLEPKRYPGWVILVGTGALGLLLLFLLGYGWAAACAGARKKRRSPPRKREEAAAVPAAAPDDLALLKNLRSEEQKKKNRKKLSEKPKPNGRTVEVAEGEAVRTPQSVTAKQPPEIDKKNEKSKKNKKKSKSDAKAVQNSSRHDGKEVDEGAWETKISHREKRQQRKRDKVLTDSGSLDSTIPGIENTITVTTEQLTTASFPVGSKKNKGDSHLNVQVSNFKSGKGDSTLQVSSGLNENLTVNGGGWNEKSVKLSSQISAGEEKWNSVSPASAGKRKTEPSAWSQDTGDANTNGKDWGRSWSDRSIFSGIGSTAEPVSQSTTSDYQWDVSRNQPYIDDEWSGLNGLSSADPNSDWNAPAEEWGNWVDEERASLLKSQEPIPDDQKVSDDDKEKGEGALPTGKSKKKKKKKKKQGEDNSTAQDTEELEKEIREDLPVNTSKTRPKQEKAFSLKTISTSDPAEVLVKNSQPIKTLPPATSTEPSVILSKSDSDKSSSQVPPILQETDKSKSNTKQNSVPPSQTKSETSWESPKQIKKKKKARRET
uniprot
proteins
function
FUNCTION: Down-regulates SLC1A2/EAAT2 promoter activity when expressed ectopically. Activates the nuclear factor kappa-B (NF-kappa-B) transcription factor. Promotes anchorage-independent growth of immortalized melanocytes and astrocytes which is a key component in tumor cell expansion. Promotes lung metastasis and also has an effect on bone and brain metastasis, possibly by enhancing the seeding of tumor cells to the target organ endothelium. Induces chemoresistance. {ECO:0000269|PubMed:15927426, ECO:0000269|PubMed:16452207, ECO:0000269|PubMed:18316612, ECO:0000269|PubMed:19111877}.
uniprot
proteins
mass_dalton
63837
uniprot
proteins
pubmed
11823860
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14980505
uniprot
proteins
pubmed
15093543
uniprot
proteins
pubmed
15383321
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15927426
uniprot
proteins
pubmed
16452207
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18316612
uniprot
proteins
pubmed
18440304
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19111877
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
582
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Cytoplasm, perinuclear region. Note=In epithelial cells, recruited to tight junctions (TJ) during the maturation of the TJ complexes. A nucleolar staining may be due to nuclear targeting of an isoform lacking the transmembrane domain (By similarity). TNF causes translocation from the cytoplasm to the nucleus. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 49..69; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins