Idh1
entrez
15926
canonical
uniprot
O88844
canonical
ensembl
ENSMUSG00000025950
resolver
ensp
ENSMUSP00000095316
resolver
ensp
ENSMUSP00000127307
resolver
enst
ENSMUST00000097709
resolver
enst
ENSMUST00000169032
resolver
genesymbol
Idh1
resolver
uniprot
Q3UAV7
resolver
uniprot_entry
IDHC_MOUSE
resolver
uniprot_sec
Q3UAV7
resolver
activity_regulation
ACTIVITY REGULATION: Irreversibly inhibited by Cd(2+) concentrations above 50 uM. {ECO:0000269|PubMed:29923039}.
uniprot
proteins
amino_acid_sequence
MSRKIQGGSVVEMQGDEMTRIIWELIKEKLILPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKYNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVTGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPKDGTQKVTYMVHDFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKKYKSQFEAQKICYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLICPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWSRGLAHRAKLDNNTELSFFAKALEDVCIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKAKLAQAKL
uniprot
proteins
ec_number
1.1.1.42
uniprot
proteins
function
FUNCTION: Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase (PubMed:12031902, PubMed:29923039). Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways (PubMed:12031902). May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency (By similarity). {ECO:0000250|UniProtKB:Q9XSG3, ECO:0000269|PubMed:12031902, ECO:0000269|PubMed:29923039, ECO:0000303|PubMed:12031902}.
uniprot
proteins
mass_dalton
46674
uniprot
proteins
mutagenesis
MUTAGEN 245; /note="C->S: No effect on inhibition by cadmium ions."; /evidence="ECO:0000269|PubMed:29923039"; MUTAGEN 379; /note="C->S: Decreased inhibition by cadmium ions."; /evidence="ECO:0000269|PubMed:29923039
uniprot
proteins
post_translational_modification
PTM: Acetylation at Lys-374 dramatically reduces catalytic activity. {ECO:0000250}.
uniprot
proteins
protein_family
Isocitrate and isopropylmalate dehydrogenases family
uniprot
proteins
pubmed
12031902
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
29923039
uniprot
proteins
pubmed
9866202
uniprot
proteins
sequence_length
414
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:12031902}.
uniprot
proteins