Nap1l1
entrez
89825
canonical
uniprot
Q9Z2G8
canonical
ensembl
ENSRNOG00000003890
resolver
ensp
ENSRNOP00000005286
resolver
ensp
ENSRNOP00000086168
resolver
ensp
ENSRNOP00000087774
resolver
ensp
ENSRNOP00000090697
resolver
enst
ENSRNOT00000005286
resolver
enst
ENSRNOT00000106121
resolver
enst
ENSRNOT00000109944
resolver
genesymbol
Nap1l1
resolver
genesymbol_syn
Nrp
resolver
uniprot
A0A8I6A6I2
resolver
uniprot
A0A8I6AE93
resolver
uniprot
G3V6H9
resolver
uniprot_entry
A0A8I6A6I2_RAT
resolver
uniprot_entry
A0A8I6AE93_RAT
resolver
uniprot_entry
G3V6H9_RAT
resolver
uniprot_entry
NP1L1_RAT
resolver
amino_acid_sequence
MADIDNKEQSELDQDLEDVEEVEEEETGEETKIKARQLTVQMMQNPQILAALQERLDGLVDTPTGYIESLPKVVKRRVNALKNLQVKCAQIEAKFYEEVHDLERKYAVLYQPLFDKRFEIINAIYEPTEEECEWKPDEEDEVSEELKEKAKIEDEKKDEEKEDPKGIPEFWLTVFKNDLLSDMVQEHDEPILKHLKDIKVKFSDAGQPMSFILEFHFEPNEYFTNEVLTKTYRMRSEPDDSDPFSFDGPEIMGCTGCQIDWKKGKNVTLKTIKKKQKHKGRGTVRTVTKTVSKTSFFNFFAPPEVPENGDLDDDXEAILAADFEIGHFLRERIIPRSVLYFTGEAIEDDDDDYDEEGEEADEEGEEEGDEENDPDYDPKKDQNPAECKQQ
uniprot
proteins
function
FUNCTION: Histone chaperone that plays a role in the nuclear import of H2A-H2B and nucleosome assembly. Also participates in several important DNA repair mechanisms: greatly enhances ERCC6-mediated chromatin remodeling which is essential for transcription-coupled nucleotide excision DNA repair. Also stimulates homologous recombination (HR) by RAD51 and RAD54 which is essential in mitotic DNA double strand break (DSB) repair (By similarity). Plays a key role in the regulation of embryonic neurogenesis (By similarity). Promotes the proliferation of neural progenitors and inhibits neuronal differentiation during cortical development (By similarity). Regulates neurogenesis via the modulation of RASSF10; regulates RASSF10 expression by promoting SETD1A-mediated H3K4 methylation at the RASSF10 promoter (By similarity). {ECO:0000250|UniProtKB:P28656, ECO:0000250|UniProtKB:P55209}.
uniprot
proteins
mass_dalton
45314
uniprot
proteins
post_translational_modification
PTM: Polyglycylated by TTLL10 on glutamate residues, resulting in polyglycine chains on the gamma-carboxyl group. Both polyglutamylation and polyglycylation modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. {ECO:0000250|UniProtKB:P28656}.; PTM: Polyglutamylated by TTLL4 on glutamate residues, resulting in polyglutamate chains on the gamma-carboxyl group. Both polyglutamylation and polyglycylation modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. {ECO:0000250|UniProtKB:P28656}.
uniprot
proteins
protein_family
Nucleosome assembly protein (NAP) family
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
390
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P28656}. Chromosome {ECO:0000250|UniProtKB:P28656}. Melanosome {ECO:0000250|UniProtKB:P55209}. Cytoplasm {ECO:0000250|UniProtKB:P28656}.
uniprot
proteins