NELFA
entrez
7469
canonical
uniprot
Q9H3P2
canonical
ensembl
ENSG00000185049
resolver
ensp
ENSP00000372335
resolver
ensp
ENSP00000445757
resolver
ensp
ENSP00000568380
resolver
enst
ENST00000542778
resolver
genesymbol
NELFA
resolver
genesymbol_syn
WHSC2
resolver
hgnc
HGNC:12768
resolver
uniprot
A0A0C4DFX9
resolver
uniprot
A2A2T1
resolver
uniprot
O95392
resolver
uniprot_entry
A0A0C4DFX9_HUMAN
resolver
uniprot_entry
NELFA_HUMAN
resolver
uniprot_sec
A2A2T1
resolver
uniprot_sec
O95392
resolver
amino_acid_sequence
MASMRESDTGLWLHNKLGATDELWAPPSIASLLTAAVIDNIRLCFHGLSSAVKLKLLLGTLHLPRRTVDEMKGALMEIIQLASLDSDPWVLMVADILKSFPDTGSLNLELEEQNPNVQDILGELREKVGECEASAMLPLECQYLNKNALTTLAGPLTPPVKHFQLKRKPKSATLRAELLQKSTETAQQLKRSAGVPFHAKGRGLLRKMDTTTPLKGIPKQAPFRSPTAPSVFSPTGNRTPIPPSRTLLRKERGVKLLDISELDMVGAGREAKRRRKTLDAEVVEKPAKEETVVENATPDYAAGLVSTQKLGSLNNEPALPSTSYLPSTPSVVPASSYIPSSETPPAPSSREASRPPEEPSAPSPTLPAQFKQRAPMYNSGLSPATPTPAAPTSPLTPTTPPAVAPTTQTPPVAMVAPQTQAPAQQQPKKNLSLTREQMFAAQEMFKTANKVTRPEKALILGFMAGSRENPCQEQGDVIQIKLSEHTEDLPKADGQGSTTMLVDTVFEMNYATGQWTRFKKYKPMTNVS
uniprot
proteins
function
FUNCTION: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:12563561, ECO:0000269|PubMed:12612062}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}.
uniprot
proteins
mass_dalton
57277
uniprot
proteins
protein_family
NELF-A family
uniprot
proteins
pubmed
10199401
uniprot
proteins
pubmed
10409432
uniprot
proteins
pubmed
11150502
uniprot
proteins
pubmed
11280764
uniprot
proteins
pubmed
11387440
uniprot
proteins
pubmed
12563561
uniprot
proteins
pubmed
12612062
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23884411
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27282391
uniprot
proteins
sequence_length
528
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11150502}.
uniprot
proteins