RGS7BP
entrez
401190
canonical
uniprot
Q6MZT1
canonical
ensembl
ENSG00000186479
resolver
ensp
ENSP00000334851
resolver
ensp
ENSP00000794925
resolver
enst
ENST00000334025
resolver
genesymbol
RGS7BP
resolver
genesymbol_syn
R7BP
resolver
hgnc
HGNC:23271
resolver
uniprot
B4DKB7
resolver
uniprot
B7Z3X1
resolver
uniprot_entry
B4DKB7_HUMAN
resolver
uniprot_entry
R7BP_HUMAN
resolver
uniprot_sec
B7Z3X1
resolver
amino_acid_sequence
MSSAPNGRKKRPSRSTRSSIFQISKPPLQSGDWERRGSGSESAHKTQRALDDCKMLVQEFNTQVALYRELVISIGDVSVSCPSLRAEMHKTRTKGCEMARQAHQKLAAISGPEDGEIHPEICRLYIQLQCCLEMYTTEMLKSICLLGSLQFHRKGKEPGGGTKSLDCKIEESAETPALEDSSSSPVDSQQHSWQVSTDIENTERDMREMKNLLSKLRETMPLPLKNQDDSSLLNLTPYPLVRRRKRRFFGLCCLISS
uniprot
proteins
function
FUNCTION: Regulator of G protein-coupled receptor (GPCR) signaling. Regulatory subunit of the R7-Gbeta5 complexes that acts by controlling the subcellular location of the R7-Gbeta5 complexes. When palmitoylated, it targets the R7-Gbeta5 complexes to the plasma membrane, leading to inhibit G protein alpha subunits. When it is unpalmitoylated, the R7-Gbeta5 complexes undergo a nuclear/cytoplasmic shuttling. May also act by controlling the proteolytic stability of R7 proteins, probably by protecting them from degradation. {ECO:0000250|UniProtKB:Q8BQP9}.
uniprot
proteins
mass_dalton
28962
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. Undergoes rapid palmitoylation turnover. De novo and turnover palmitoylation are both mediated by ZDHHC2. Palmitoylation regulates the cell membrane and nuclear shuttling and the regulation of GPCR signaling. Upon depalmitoylation, it is targeted from the plasma membrane into the nucleus. GPCR signaling inhibits depalmitoylation and promotes localization to the plasma membrane. {ECO:0000250|UniProtKB:Q8BQP9}.
uniprot
proteins
protein_family
RGS7BP/RGS9BP family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
sequence_length
257
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8BQP9}. Cytoplasm {ECO:0000250|UniProtKB:Q8BQP9}. Cell membrane {ECO:0000250|UniProtKB:Q8BQP9}; Lipid-anchor {ECO:0000250|UniProtKB:Q8BQP9}. Note=Shuttling between the plasma membrane, the cytoplasm and the nucleus is regulated by palmitoylation. {ECO:0000250|UniProtKB:Q8BQP9}.
uniprot
proteins