Tsen15
entrez
66637
canonical
uniprot
Q8R3W5
canonical
ensembl
ENSMUSG00000014980
resolver
ensp
ENSMUSP00000015124
resolver
enst
ENSMUST00000015124
resolver
genesymbol
Tsen15
resolver
genesymbol_syn
Sen15
resolver
uniprot
A6H601
resolver
uniprot
G3X8S8
resolver
uniprot
Q9CQW8
resolver
uniprot
Q9CYI5
resolver
uniprot_entry
G3X8S8_MOUSE
resolver
uniprot_entry
SEN15_MOUSE
resolver
uniprot_sec
A6H601
resolver
uniprot_sec
Q9CQW8
resolver
uniprot_sec
Q9CYI5
resolver
amino_acid_sequence
MEERSDSEPTPGCSGPGPAPVRDGGGAHTWAPEDAWMGTHPKYLEMMELDIGDATQVYIAFLVYLDLMESKSWHEVNCVGIPELQLICLLGTEIEGEGLQTVVPTPISASLSHNRIREILKASRKLQGDPELPMSFTLAIVESDSTIVYYKLTDGFMLPDPQNISLRR
uniprot
proteins
function
FUNCTION: Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
18530
uniprot
proteins
protein_family
SEN15 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
168
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Nucleus, nucleolus {ECO:0000305}. Note=May be transiently localized in the nucleolus. {ECO:0000305}.
uniprot
proteins