TXNDC17
entrez
84817
canonical
uniprot
Q9BRA2
canonical
ensembl
ENSG00000129235
resolver
ensp
ENSP00000250101
resolver
enst
ENST00000250101
resolver
genesymbol
TXNDC17
resolver
genesymbol_syn
TXNL5
resolver
hgnc
HGNC:28218
resolver
uniprot
A0A140VJY7
resolver
uniprot
A8K7E8
resolver
uniprot_entry
A0A140VJY7_HUMAN
resolver
uniprot_entry
TXD17_HUMAN
resolver
uniprot_sec
A8K7E8
resolver
amino_acid_sequence
MARYEEVSVSGFEEFHRAVEQHNGKTIFAYFTGSKDAGGKSWCPDCVQAEPVVREGLKHISEGCVFIYCQVGEKPYWKDPNNDFRKNLKVTAVPTLLKYGTPQKLVESECLQANLVEMLFSED
uniprot
proteins
function
FUNCTION: Disulfide reductase. May participate in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyze dithiol-disulfide exchange reactions. Modulates TNF signaling and NF-kappa-B activation. Has peroxidase activity and may contribute to the elimination of cellular hydrogen peroxide. {ECO:0000269|PubMed:14607843, ECO:0000269|PubMed:14607844}.
uniprot
proteins
mass_dalton
13941
uniprot
proteins
mutagenesis
MUTAGEN 43; /note="C->S: Loss of peroxidase activity."; /evidence="ECO:0000269|PubMed:14607844"; MUTAGEN 46; /note="C->S: Loss of peroxidase activity."; /evidence="ECO:0000269|PubMed:14607844
uniprot
proteins
post_translational_modification
PTM: The oxidized protein is reduced by TRXR1.
uniprot
proteins
protein_family
Thioredoxin family
uniprot
proteins
pubmed
14607843
uniprot
proteins
pubmed
14607844
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15355959
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
sequence_length
123
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14607844}.
uniprot
proteins