TMED9
entrez
54732
canonical
uniprot
Q9BVK6
canonical
ensembl
ENSG00000184840
resolver
ensp
ENSP00000330945
resolver
enst
ENST00000332598
resolver
genesymbol
TMED9
resolver
genesymbol_syn
GP25L2
resolver
hgnc
HGNC:24878
resolver
uniprot
Q14437
resolver
uniprot
Q8WZ61
resolver
uniprot_entry
TMED9_HUMAN
resolver
uniprot_sec
Q14437
resolver
uniprot_sec
Q8WZ61
resolver
amino_acid_sequence
MAVELGVLLVRPRPGTGLGRVMRTLLLVLWLATRGSALYFHIGETEKKCFIEEIPDETMVIGNYRTQLYDKQREEYQPATPGLGMFVEVKDPEDKVILARQYGSEGRFTFTSHTPGEHQICLHSNSTKFSLFAGGMLRVHLDIQVGEHANDYAEIAAKDKLSELQLRVRQLVEQVEQIQKEQNYQRWREERFRQTSESTNQRVLWWSILQTLILVAIGVWQMRHLKSFFEAKKLV
uniprot
proteins
function
FUNCTION: Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer-dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB. {ECO:0000269|PubMed:10852829, ECO:0000269|PubMed:14600267, ECO:0000269|PubMed:16595549, ECO:0000269|PubMed:18287528, ECO:0000269|PubMed:19296914}.
uniprot
proteins
mass_dalton
27277
uniprot
proteins
mutagenesis
MUTAGEN 232..233; /note="KK->SS: Localization to plasma membrane and endocytosis."; /evidence="ECO:0000269|PubMed:14600267
uniprot
proteins
post_translational_modification
PTM: N-linked glycosylated containing high mannose. {ECO:0000269|PubMed:10359607, ECO:0000269|PubMed:12754519, ECO:0000269|PubMed:19159218}.
uniprot
proteins
protein_family
EMP24/GP25L family
uniprot
proteins
pubmed
10359607
uniprot
proteins
pubmed
10852829
uniprot
proteins
pubmed
12237308
uniprot
proteins
pubmed
12754519
uniprot
proteins
pubmed
14600267
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15537668
uniprot
proteins
pubmed
16595549
uniprot
proteins
pubmed
16940185
uniprot
proteins
pubmed
18287528
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19296914
uniprot
proteins
pubmed
19948005
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21545355
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
235
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Cycles between compartments of the early secretatory pathway.
uniprot
proteins
transmembrane_region
TRANSMEM 203..222; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins