Grp
entrez
225642
canonical
uniprot
Q8R1I2
canonical
ensembl
ENSMUSG00000024517
resolver
ensp
ENSMUSP00000025395
resolver
ensp
ENSMUSP00000133437
resolver
enst
ENSMUST00000025395
resolver
enst
ENSMUST00000173985
resolver
genesymbol
Grp
resolver
uniprot
Q3UTL2
resolver
uniprot_entry
GRP_MOUSE
resolver
uniprot_sec
Q3UTL2
resolver
amino_acid_sequence
MRGSELSLLLLALVLCQAPRGPAAPVSTGAGGGTVLAKMYPRGSHWAVGHLMGKKSTDESPSLYAADRDGLKEQLRGYVRWEEAARDLLDLLEAAGNQSHQPPQHPPLSLQPTWDPEDGSYFNDVQTAKLVDSLLQVLKEKGGTAS
uniprot
proteins
function
FUNCTION: Stimulates the release of gastrin and other gastrointestinal hormones (By similarity). Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior (PubMed:17653196, PubMed:26658875, PubMed:28280205). Contributes primarily to nonhistaminergic itch sensation (PubMed:28280205). In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (PubMed:12526815). In another study, shown to act on vasoactive intestinal peptide (VIP)-expressing cells in the auditory cortex, most likely via extrasynaptic diffusion from local and long-range sources, to mediate disinhibition of glutamatergic cells via VIP cell-specific GRPR signaling which leads to enhanced auditory fear memories (PubMed:34610277). Contributes to the regulation of food intake (PubMed:12176666). Inhibits voltage-gated sodium channels but enhances voltage-gated potassium channels in hippocampal neurons (By similarity). Contributes to the induction of sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (PubMed:26855425). {ECO:0000250|UniProtKB:P24393, ECO:0000250|UniProtKB:P63153, ECO:0000269|PubMed:12176666, ECO:0000269|PubMed:12526815, ECO:0000269|PubMed:17653196, ECO:0000269|PubMed:26658875, ECO:0000269|PubMed:26855425, ECO:0000269|PubMed:28280205, ECO:0000269|PubMed:34610277}.; FUNCTION: [Neuromedin-C]: Induces an itch response through activation of receptors present on mast cells, triggering mast cell degranulation. {ECO:0000269|PubMed:21933692}.
uniprot
proteins
mass_dalton
15659
uniprot
proteins
protein_family
Bombesin/neuromedin-B/ranatensin family
uniprot
proteins
pubmed
12176666
uniprot
proteins
pubmed
12526815
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17653196
uniprot
proteins
pubmed
21933692
uniprot
proteins
pubmed
26658875
uniprot
proteins
pubmed
26855425
uniprot
proteins
pubmed
28280205
uniprot
proteins
pubmed
34610277
uniprot
proteins
sequence_length
146
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P07492}. Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000250|UniProtKB:Q863C3}. Cell projection, neuron projection {ECO:0000269|PubMed:26855425}. Note=In neurons of the retrotrapezoid nucleus/parafacial respiratory group, expressed on neuron projections which project into the pre-Botzinger complex. {ECO:0000269|PubMed:26855425}.
uniprot
proteins