Rab3a
entrez
19339
canonical
uniprot
P63011
canonical
ensembl
ENSMUSG00000031840
resolver
ensp
ENSMUSP00000034301
resolver
ensp
ENSMUSP00000105717
resolver
ensp
ENSMUSP00000105719
resolver
ensp
ENSMUSP00000105720
resolver
ensp
ENSMUSP00000272383
resolver
ensp
ENSMUSP00000272384
resolver
enst
ENSMUST00000034301
resolver
enst
ENSMUST00000110090
resolver
enst
ENSMUST00000110092
resolver
enst
ENSMUST00000110093
resolver
genesymbol
Rab3a
resolver
genesymbol_syn
Rab3A
resolver
uniprot
P05713
resolver
uniprot
Q0PD63
resolver
uniprot
Q3TSL4
resolver
uniprot_entry
Q0PD63_MOUSE
resolver
uniprot_entry
RAB3A_MOUSE
resolver
uniprot_sec
P05713
resolver
uniprot_sec
Q3TSL4
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) including RAB3IL1 and MADD which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) including RAB3GAP1 and TBC1D10B which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs) which prevent Rab-GDP dissociation. {ECO:0000250|UniProtKB:P20336}.
uniprot
proteins
amino_acid_sequence
MASATDSRYGQKESSDQNFDYMFKILIIGNSSVGKTSFLFRYADDSFTPAFVSTVGIDFKVKTIYRNDKRIKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWSTQIKTYSWDNAQVLLVGNKCDMEDERVVSSERGRQLADHLGFEFFEASAKDNINVKQTFERLVDVICEKMSESLDTADPAVTGAKQGPQLTDQQAPPHQDCAC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB3A plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (PubMed:11598194). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By similarity). Stimulates insulin secretion through interaction with RIMS2 isoform RIMS2 and RPH3AL effectors in pancreatic beta cells (PubMed:15159548, PubMed:20674857). Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9 (By similarity). Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1 (By similarity). Plays a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT (By similarity). {ECO:0000250|UniProtKB:P20336, ECO:0000250|UniProtKB:P63012, ECO:0000269|PubMed:11598194, ECO:0000269|PubMed:15159548, ECO:0000269|PubMed:20674857}.
uniprot
proteins
mass_dalton
24970
uniprot
proteins
mutagenesis
MUTAGEN 36; /note="T->N: Reduced axon localization and aggregation in neuronal cell bodies."; /evidence="ECO:0000269|PubMed:18849981"; MUTAGEN 81; /note="Q->L: No effect on neurite transport. Reduced axonal transport in a Madd RNAi-mediated knockdown or a Kif1b knockout background."; /evidence="ECO:0000269|PubMed:18849981
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Thr-86 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2. {ECO:0000250|UniProtKB:P20336}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
11056535
uniprot
proteins
pubmed
11431472
uniprot
proteins
pubmed
11598194
uniprot
proteins
pubmed
12401793
uniprot
proteins
pubmed
12578829
uniprot
proteins
pubmed
12590134
uniprot
proteins
pubmed
15159548
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17509819
uniprot
proteins
pubmed
18849981
uniprot
proteins
pubmed
20674857
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29125462
uniprot
proteins
pubmed
31651360
uniprot
proteins
pubmed
7687127
uniprot
proteins
sequence_length
220
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P63012}. Lysosome {ECO:0000250|UniProtKB:P20336}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:P63012}. Cell projection, axon {ECO:0000269|PubMed:18849981}. Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Presynapse {ECO:0000269|PubMed:31651360}. Postsynapse {ECO:0000269|PubMed:31651360}. Note=Cycles between a vesicle-associated GTP-bound form and a cytosolic GDP-bound form. {ECO:0000250|UniProtKB:P63012}.
uniprot
proteins