Pla2g4f
entrez
271844
canonical
uniprot
Q50L41
canonical
ensembl
ENSMUSG00000046971
resolver
ensp
ENSMUSP00000062607
resolver
ensp
ENSMUSP00000332063
resolver
enst
ENSMUST00000054651
resolver
genesymbol
Pla2g4f
resolver
uniprot
A2AQJ2
resolver
uniprot
Q80VQ8
resolver
uniprot
Q80VV9
resolver
uniprot_entry
PA24F_MOUSE
resolver
uniprot_sec
A2AQJ2
resolver
uniprot_sec
Q80VQ8
resolver
uniprot_sec
Q80VV9
resolver
activity_regulation
ACTIVITY REGULATION: Stimulated by cytosolic Ca(2+). {ECO:0000269|PubMed:15866882, ECO:0000269|PubMed:17293613}.
uniprot
proteins
amino_acid_sequence
MPWTLQPKWLAGKGLPLLGAILLRKTEKSEPQWKHRRQETHPYYDLQVKVLRARNIQHTDKLSKADCYVRLWLPTASVSPSQTRTVVNSSDPEWNETFPYQIHGAVKNVLELALYDEDVLDSDNVFSILFDTSTLQLGQPCTKNFTRQQDPKELEVEFTLEKSQTPASEVVTNGVLVAHPCLRIQGTVTGDKTASLGELGSRQIQLAVPGAYEKPQPLQPTSEPGLPVNFTFHVNPVLSPKLHIKLQEQLQVFHSGPSDELEAQTSKMDKASILLSSLPLNEELTKLVDLEEGQQVSLRMKADMSSSGDLDLRLGFDLCDGEQEFLDKRKQVASKALQRVMGLSEALHCDQVPVVAVLGSGGGTRAMTSLYGSLAGLQELGLLDAVTYLSGVSGSSWCISTLYRDPSWSQKALQGPIKYASERVCSSKIGMLSPKQFEYYSREKRAWESRGHSMSFTDLWGLIIEYFLNQEENPAKLSDQQETVSQGQNPYPIYASINVHKNISGDDFAEWCEFTPYEVGFPKYGAYVPTELFGSEFFMGRLLHFWPEPRICYLQGMWGSAFAASLYEIFLKLGGLSLSFLDWHRGSVSVTDDWPKLRKQDPTRLPTRLFTPMSSFSQAVLDIFTSRITCAQTFNFTRGLCMYKDYTARKDFVVSEDAWHSHNYGYPDACPNQLTPMKDFLSLVDGGFAINSPFPLVLQPQRAVDLIVSFDYSLEGPFEVLQVTEKYCRDRGIPFPRIEVDPKDSEDPRECYLFAEAEDPCSPIVLHFPLVNRTFRTHLAPGVERQTAEEKAFGDFIINGPDTAYGMMDFTYEPKEFDRLVTLSRYNVLNNKETIRHALQLALDRRRQAGGRVGG
uniprot
proteins
ec_number
3.1.1.4
uniprot
proteins
function
FUNCTION: Has calcium-dependent phospholipase and lysophospholipase activities with a potential role in membrane lipid remodeling and biosynthesis of lipid mediators (PubMed:15866882, PubMed:17293613). Preferentially hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:15866882, PubMed:17293613). Selectively hydrolyzes sn-2 arachidonoyl group from membrane phospholipids, providing the precursor for eicosanoid biosynthesis (PubMed:15866882, PubMed:17293613). In myocardial mitochondria, plays a major role in arachidonate release that is metabolically channeled to the formation of cardioprotective eicosanoids, epoxyeicosatrienoates (EETs) (By similarity). {ECO:0000250|UniProtKB:Q68DD2, ECO:0000269|PubMed:15866882, ECO:0000269|PubMed:17293613}.
uniprot
proteins
mass_dalton
96364
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15866882
uniprot
proteins
pubmed
17293613
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
855
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:15866882, ECO:0000269|PubMed:17293613}. Cell membrane {ECO:0000269|PubMed:17293613}; Peripheral membrane protein {ECO:0000305}. Mitochondrion {ECO:0000250|UniProtKB:Q68DD2}.
uniprot
proteins