TRIOBP
entrez
11078
canonical
uniprot
Q9H2D6
canonical
ensembl
ENSG00000100106
resolver
ensp
ENSP00000383913
resolver
ensp
ENSP00000386026
resolver
ensp
ENSP00000496394
resolver
genesymbol
TRIOBP
resolver
genesymbol_syn
KIAA1662
resolver
genesymbol_syn
TARA
resolver
hgnc
HGNC:17009
resolver
uniprot
B1AHD4
resolver
uniprot
B1AHD7
resolver
uniprot
F2Z2W0
resolver
uniprot
F8W6V6
resolver
uniprot
O94797
resolver
uniprot
Q2PZW8
resolver
uniprot
Q2Q3Z9
resolver
uniprot
Q2Q400
resolver
uniprot
Q5R3M6
resolver
uniprot
Q96DW1
resolver
uniprot
Q9BT77
resolver
uniprot
Q9BTL7
resolver
uniprot
Q9BY98
resolver
uniprot
Q9Y3L4
resolver
uniprot_entry
TARA_HUMAN
resolver
uniprot_sec
B1AHD4
resolver
uniprot_sec
B1AHD7
resolver
uniprot_sec
F2Z2W0
resolver
uniprot_sec
F8W6V6
resolver
uniprot_sec
O94797
resolver
uniprot_sec
Q2PZW8
resolver
uniprot_sec
Q2Q3Z9
resolver
uniprot_sec
Q2Q400
resolver
uniprot_sec
Q5R3M6
resolver
uniprot_sec
Q96DW1
resolver
uniprot_sec
Q9BT77
resolver
uniprot_sec
Q9BTL7
resolver
uniprot_sec
Q9BY98
resolver
uniprot_sec
Q9Y3L4
resolver
amino_acid_sequence
MEEVPGDALCEHFEANILTQNRCQNCFHPEEAHGARYQELRSPSGAEVPYCDLPRCPPAPEDPLSASTSGCQSVVDPGLRPGPKRGPSPSAGLPEEGPTAAPRSRSRELEAVPYLEGLTTSLCGSCNEDPGSDPTSSPDSATPDDTSNSSSVDWDTVERQEEEAPSWDELAVMIPRRPREGPRADSSQRAPSLLTRSPVGGDAAGQKKEDTGGGGRSAGQHWARLRGESGLSLERHRSTLTQASSMTPHSGPRSTTSQASPAQRDTAQAASTREIPRASSPHRITQRDTSRASSTQQEISRASSTQQETSRASSTQEDTPRASSTQEDTPRASSTQWNTPRASSPSRSTQLDNPRTSSTQQDNPQTSFPTCTPQRENPRTPCVQQDDPRASSPNRTTQRENSRTSCAQRDNPKASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPSRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRAARDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRATRDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCAQRDNPRASSPNRTTQQDSPRTSCARRDDPRASSPNRTIQQENPRTSCALRDNPRASSPSRTIQQENPRTSCAQRDDPRASSPNRTTQQENPRTSCARRDNPRASSRNRTIQRDNPRTSCAQRDNPRASSPNRTIQQENLRTSCTRQDNPRTSSPNRATRDNPRTSCAQRDNLRASSPIRATQQDNPRTCIQQNIPRSSSTQQDNPKTSCTKRDNLRPTCTQRDRTQSFSFQRDNPGTSSSQCCTQKENLRPSSPHRSTQWNNPRNSSPHRTNKDIPWASFPLRPTQSDGPRTSSPSRSKQSEVPWASIALRPTQGDRPQTSSPSRPAQHDPPQSSFGPTQYNLPSRATSSSHNPGHQSTSRTSSPVYPAAYGAPLTSPEPSQPPCAVCIGHRDAPRASSPPRYLQHDPFPFFPEPRAPESEPPHHEPPYIPPAVCIGHRDAPRASSPPRHTQFDPFPFLPDTSDAEHQCQSPQHEPLQLPAPVCIGYRDAPRASSPPRQAPEPSLLFQDLPRASTESLVPSMDSLHECPHIPTPVCIGHRDAPSFSSPPRQAPEPSLFFQDPPGTSMESLAPSTDSLHGSPVLIPQVCIGHRDAPRASSPPRHPPSDLAFLAPSPSPGSSGGSRGSAPPGETRHNLEREEYTVLADLPPPRRLAQRQPGPQAQCSSGGRTHSPGRAEVERLFGQERRKSEAAGAFQAQDEGRSQQPSQGQSQLLRRQSSPAPSRQVTMLPAKQAELTRRSQAEPPHPWSPEKRPEGDRQLQGSPLPPRTSARTPERELRTQRPLESGQAGPRQPLGVWQSQEEPPGSQGPHRHLERSWSSQEGGLGPGGWWGCGEPSLGAAKAPEGAWGGTSREYKESWGQPEAWEEKPTHELPRELGKRSPLTSPPENWGGPAESSQSWHSGTPTAVGWGAEGACPYPRGSERRPELDWRDLLGLLRAPGEGVWARVPSLDWEGLLELLQARLPRKDPAGHRDDLARALGPELGPPGTNDVPEQESHSQPEGWAEATPVNGHSPALQSQSPVQLPSPACTSTQWPKIKVTRGPATATLAGLEQTGPLGSRSTAKGPSLPELQFQPEEPEESEPSRGQDPLTDQKQADSADKRPAEGKAGSPLKGRLVTSWRMPGDRPTLFNPFLLSLGVLRWRRPDLLNFKKGWMSILDEPGEPPSPSLTTTSTSQWKKHWFVLTDSSLKYYRDSTAEEADELDGEIDLRSCTDVTEYAVQRNYGFQIHTKDAVYTLSAMTSGIRRNWIEALRKTVRPTSAPDVTKLSDSNKENALHSYSTQKGPLKAGEQRAGSEVISRGGPRKADGQRQALDYVELSPLTQASPQRARTPARTPDRLAKQEELERDLAQRSEERRKWFEATDSRTPEVPAGEGPRRGLGAPLTEDQQNRLSEEIEKKWQELEKLPLRENKRVPLTALLNQSRGERRGPPSDGHEALEKEVQALRAQLEAWRLQGEAPQSALRSQEDGHIPPGYISQEACERSLAEMESSHQQVMEELQRHHERELQRLQQEKEWLLAEETAATASAIEAMKKAYQEELSRELSKTRSLQQGPDGLRKQHQSDVEALKRELQVLSEQYSQKCLEIGALMRQAEEREHTLRRCQQEGQELLRHNQELHGRLSEEIDQLRGFIASQGMGNGCGRSNERSSCELEVLLRVKENELQYLKKEVQCLRDELQMMQKDKRFTSGKYQDVYVELSHIKTRSEREIEQLKEHLRLAMAALQEKESMRNSLAE
uniprot
proteins
disease_involvement
DISEASE: Deafness, autosomal recessive, 28 (DFNB28) [MIM:609823]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269|PubMed:16385457, ECO:0000269|PubMed:16385458}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: [Isoform 1]: Regulates actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin and prevents its depolymerization (PubMed:18194665, PubMed:28438837). May also serve as a linker protein to recruit proteins required for F-actin formation and turnover (PubMed:18194665). Essential for correct mitotic progression (PubMed:22820163, PubMed:24692559). {ECO:0000269|PubMed:18194665, ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559, ECO:0000269|PubMed:28438837}.; FUNCTION: [Isoform 5]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.; FUNCTION: [Isoform 4]: Plays a pivotal role in the formation of stereocilia rootlets. {ECO:0000250|UniProtKB:Q99KW3}.
uniprot
proteins
mass_dalton
261376
uniprot
proteins
mutagenesis
MUTAGEN Q9H2D6-5:221; /note="T->A: Does not affect interaction with TERF1. Remains associated with TERF1 at the telomere in late prometaphase cells."; /evidence="ECO:0000269|PubMed:28438837"; MUTAGEN Q9H2D6-5:221; /note="T->E: Abolishes interaction with TERF1."; /evidence="ECO:0000269|PubMed:28438837"; MUTAGEN Q9H2D6-5:457; /note="T->A: Prevents the localization of TERF1 to the centrosome."; /evidence="ECO:0000269|PubMed:28438837"; MUTAGEN Q9H2D6-5:457; /note="T->E: Does not affect interaction with TERF1."; /evidence="ECO:0000269|PubMed:28438837
uniprot
proteins
post_translational_modification
PTM: [Isoform 1]: Ubiquitinated by HECTD3, leading to its degradation by the proteasome. {ECO:0000269|PubMed:18194665}.; PTM: [Isoform 1]: Phosphorylation at Thr-457 by PLK1 ensures mitotic progression and is essential for accurate chromosome segregation (PubMed:22820163). Phosphorylation at residues Thr-221 and Thr-457 by kinase NEK2A and PLK1 coordinates TERF1 translocation from telomere to spindle pole (PubMed:24692559). {ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559}.
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
11148140
uniprot
proteins
pubmed
11258795
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16385457
uniprot
proteins
pubmed
16385458
uniprot
proteins
pubmed
18194665
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22820163
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24692559
uniprot
proteins
pubmed
25333879
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28438837
uniprot
proteins
pubmed
9853615
uniprot
proteins
sequence_length
2365
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9853615}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:22820163}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:22820163, ECO:0000269|PubMed:24692559}. Midbody {ECO:0000269|PubMed:22820163}. Chromosome, telomere {ECO:0000269|PubMed:24692559}. Note=Centrosomal localization occurs upon phosphorylation by PLK1 at Thr-457 and lasts from prophase to anaphase. At telophase, relocalizes to midbody. {ECO:0000269|PubMed:22820163}.
uniprot
proteins