Kcnq4
entrez
60613
canonical
uniprot
Q9JK97
canonical
ensembl
ENSMUSG00000028631
resolver
ensp
ENSMUSP00000030376
resolver
ensp
ENSMUSP00000317262
resolver
ensp
ENSMUSP00000317263
resolver
ensp
ENSMUSP00000317267
resolver
enst
ENSMUST00000030376
resolver
genesymbol
Kcnq4
resolver
uniprot
A2A7E8
resolver
uniprot
Q8C9Y6
resolver
uniprot_entry
KCNQ4_MOUSE
resolver
uniprot_sec
A2A7E8
resolver
uniprot_sec
Q8C9Y6
resolver
activity_regulation
ACTIVITY REGULATION: Two molecules of phosphatidylinositol-4,5-bisphosphate (PIP2-I and PIP2-II) are essential to activate KCNQ4 channel by inducing the coupling of the voltage-sensing domain (VSD) and the pore-forming domain (PD). Upon channel activation, PIP2-I and PIP2-II disrupt the VSD-calmodulin/CALM interaction, causing the release of CALM from the VSD which triggers the opening of the gate. Calcium suppresses KCNQ4 channel current through calcium-bound CALM C-terminus. Therefore CALM acts as calcium sensor that controls channel activity. {ECO:0000250|UniProtKB:P56696}.
uniprot
proteins
amino_acid_sequence
MAEAPPRRLGLGPPPGDAPRAELVALTAVQSEQGEAGGGGSPRRLGLLGSPLPPGAPLPGPGSGSGSACGGQRSSAAQKRYRRLQNWVYNVLERPRGWAFVYHVFIFLLVFSCLVLSVLSTIQEHQELANECLLILEFVMIVVFGLEYIIRVWSAGCCCRYRGWQGRFRFARKPFCVIDFIVFVASVAVIAAGTQGNIFATSALRSMRFLQILRMVRMDRRGGTWKLLGSVVYAHSKELITAWYIGFLVLIFASFLVYLAEKDANSDFSSYADSLWWGTITLTTIGYGDKTPHTWLGRVLAAGFALLGISFFALPAGILGSGFALKVQEQHRQKHFEKRRMPAANLIQAAWRLYSTDTSRAYLTATWYYYDSILPSFRELALLFEHIQRARNGGLRPLEVRRAPVPDGAPSRYPPVATCHRPGSASFCPGESSRMGIKDRIRISSSQKRTGPSKQHLAPPPIPTSPSSEQVGEASSPSKVQKSWSFNDRTRFRASLRLKPRCSAEEGPSEEVAEEKSYQCELTVDDVMPAVKTVIRSVRILKFLVAKRKFKETLRPYDVKDVIEQYSAGHLDMLGRIKSLQARVDQIVGRGPGDRKTREKGDKGPSDTEAVDEISMMGRVVKVEKQVQSIEHKLDLLLGFYSRCLRSGTSASLGTVQVPLFDPDITSDYHSPVDHEDISVSAQTLSISRSVSTNMD
uniprot
proteins
function
FUNCTION: Pore-forming subunit of the voltage-gated potassium (Kv) channel involved in the regulation of sensory cells excitability in the cochlea. KCNQ4/Kv7.4 channel is composed of 4 pore-forming subunits assembled as tetramers. Promotes the outflow of potassium ions in the repolarization phase of action potential which plays a role in regulating membrane potential of excitable cells. The channel conducts a slowly activating and deactivating current. Current often shows some inward rectification at positive potentials. Channel may be selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) = Rb(+) > Cs(+) > Na(+). Important for normal physiological function of inner ear such as sensory perception of sound. {ECO:0000250|UniProtKB:P56696}.
uniprot
proteins
mass_dalton
77057
uniprot
proteins
protein_family
KQT (TC 1.A.1.15) subfamily
uniprot
proteins
protein_family
Kv7.4/KCNQ4 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
10760300
uniprot
proteins
pubmed
11042367
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
696
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basal cell membrane {ECO:0000250|UniProtKB:Q9JK96}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P56696}. Note=Situated at the basal membrane of cochlear outer hair cells. {ECO:0000250|UniProtKB:Q9JK96}.
uniprot
proteins
transmembrane_region
TRANSMEM 98..119; /note="Helical; Name=Segment S1"; /evidence="ECO:0000250|UniProtKB:P56696"; TRANSMEM 131..153; /note="Helical; Name=Segment S2"; /evidence="ECO:0000250|UniProtKB:P56696"; TRANSMEM 170..192; /note="Helical; Name=Segment S3"; /evidence="ECO:0000250|UniProtKB:P56696"; TRANSMEM 204..224; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000250|UniProtKB:P56696"; TRANSMEM 237..259; /note="Helical; Name=Segment S5"; /evidence="ECO:0000250|UniProtKB:P56696"; TRANSMEM 295..323; /note="Helical; Name=Segment S6"; /evidence="ECO:0000250|UniProtKB:P56696
uniprot
proteins