Gdf11
entrez
14561
canonical
uniprot
Q9Z1W4
canonical
ensembl
ENSMUSG00000025352
resolver
ensp
ENSMUSP00000026408
resolver
enst
ENSMUST00000026408
resolver
genesymbol
Gdf11
resolver
genesymbol_syn
Bmp11
resolver
uniprot
Q9QX55
resolver
uniprot
Q9R221
resolver
uniprot_entry
GDF11_MOUSE
resolver
uniprot_sec
Q9QX55
resolver
uniprot_sec
Q9R221
resolver
amino_acid_sequence
MVLAAPLLLGFLLLALELRPRGEAAEGPAAAAAAAAAAAGVGGERSSRPAPSAPPEPDGCPVCVWRQHSRELRLESIKSQILSKLRLKEAPNISREVVKQLLPKAPPLQQILDLHDFQGDALQPEDFLEEDEYHATTETVISMAQETDPAVQTDGSPLCCHFHFSPKVMFTKVLKAQLWVYLRPVPRPATVYLQILRLKPLTGEGTAGGGGGGRRHIRIRSLKIELHSRSGHWQSIDFKQVLHSWFRQPQSNWGIEINAFDPSGTDLAVTSLGPGAEGLHPFMELRVLENTKRSRRNLGLDCDEHSSESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGQCEYMFMQKYPHTHLVQQANPRGSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGCS
uniprot
proteins
function
FUNCTION: Secreted signal that acts globally to regulate anterior/posterior axial patterning during development (PubMed:10391213). May play critical roles in patterning both mesodermal and neural tissues (PubMed:10391213). It is required for proper vertebral patterning and orofacial development (By similarity). Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed:12414726, PubMed:16845371). {ECO:0000250|UniProtKB:O95390, ECO:0000269|PubMed:10391213, ECO:0000269|PubMed:12414726, ECO:0000269|PubMed:16845371}.
uniprot
proteins
mass_dalton
44947
uniprot
proteins
mutagenesis
MUTAGEN 120; /note="D->A: Inhibits processing of prodomain."; /evidence="ECO:0000269|PubMed:15988002
uniprot
proteins
post_translational_modification
PTM: Synthesized as large precursor molecule that undergoes proteolytic cleavage by furin-like proteases (By similarity). This produces an inactive form consisting of the mature C-terminal portion non-covalently bound to its cleaved N-terminal propeptide. Activation of the mature form requires additional cleavage of the propeptide by a tolloid-like metalloproteinase. {ECO:0000250|UniProtKB:O95390, ECO:0000269|PubMed:15988002}.
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
10072786
uniprot
proteins
pubmed
10075854
uniprot
proteins
pubmed
10391213
uniprot
proteins
pubmed
12414726
uniprot
proteins
pubmed
15988002
uniprot
proteins
pubmed
16845371
uniprot
proteins
sequence_length
405
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
uniprot
proteins