Rnf7
entrez
19823
canonical
uniprot
Q9WTZ1
canonical
ensembl
ENSMUSG00000051234
resolver
ensp
ENSMUSP00000052856
resolver
ensp
ENSMUSP00000108581
resolver
enst
ENSMUST00000057500
resolver
enst
ENSMUST00000071301
resolver
genesymbol
Rnf7
resolver
genesymbol_syn
Rbx2
resolver
genesymbol_syn
Sag
resolver
uniprot
D3Z392
resolver
uniprot
Q3UKF8
resolver
uniprot_entry
D3Z392_MOUSE
resolver
uniprot_entry
RBX2_MOUSE
resolver
uniprot_sec
Q3UKF8
resolver
amino_acid_sequence
MADVEDGEEPCVLSSHSGSAGSKSGGDKMFSLKKWNAVAMWSWDVECDTCAICRVQVMDACLRCQAENKQEDCVVVWGECNHSFHNCCMSLWVKQNNRCPLCQQDWVVQRIGK
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
ec_number
2.3.2.32
uniprot
proteins
function
FUNCTION: Catalytic component of multiple cullin-5-RING E3 ubiquitin-protein ligase complexes (ECS complexes), which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:22118770, PubMed:24210661, PubMed:29361558). It is thereby involved in various biological processes, such as cell cycle progression, signal transduction and transcription (PubMed:22118770, PubMed:24210661, PubMed:29361558). The functional specificity of the E3 ubiquitin-protein ligase ECS complexes depend on the variable SOCS box-containing substrate recognition component (PubMed:24210661). Within ECS complexes, RNF7/RBX2 recruits the E2 ubiquitination enzyme to the complex via its RING-type and brings it into close proximity to the substrate (By similarity). Catalytic subunit of various SOCS-containing ECS complexes, such as the ECS(SOCS7) complex, that regulate reelin signaling by mediating ubiquitination and degradation of DAB1 (PubMed:24210661, PubMed:29361558). The ECS(SOCS2) complex mediates the ubiquitination and subsequent proteasomal degradation of phosphorylated EPOR and GHR (By similarity). Promotes ubiquitination and degradation of NF1, thereby regulating Ras protein signal transduction (PubMed:22118770). As part of the ECS(ASB9) complex, catalyzes ubiquitination and degradation of CKB (By similarity). The ECS(SPSB3) complex catalyzes ubiquitination of nuclear CGAS (By similarity). As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (By similarity). The ECS(ASB7) complex acts a negative regulator of H3K9me3 histone mark by mediating ubiquitination and degradation of SUV39H1 (By similarity). As part of some ECS complex, catalyzes 'Lys-11'-linked ubiquitination and degradation of BTRC (By similarity). ECS complexes and ARIH2 collaborate in tandem to mediate ubiquitination of target proteins; ARIH2 mediating addition of the first ubiquitin on CRLs targets (By similarity). As part of the ECS(LRRC58) complex, mediates CDO1 ubiquitination and degradation, regulating cysteine catabolism (By similarity). Specifically catalyzes the neddylation of CUL5 via its interaction with UBE2F (By similarity). Does not catalyze neddylation of other cullins (CUL1, CUL2, CUL3, CUL4A or CUL4B) (By similarity). May play a role in protecting cells from apoptosis induced by redox agents (By similarity). {ECO:0000250|UniProtKB:Q9UBF6, ECO:0000269|PubMed:22118770, ECO:0000269|PubMed:24210661, ECO:0000269|PubMed:29361558}.
uniprot
proteins
mass_dalton
12707
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:22118770, ECO:0000269|PubMed:24210661, ECO:0000269|PubMed:29361558}.; PATHWAY: Protein modification; protein neddylation. {ECO:0000250|UniProtKB:Q9UBF6}.
uniprot
proteins
protein_family
RING-box family
uniprot
proteins
pubmed
10082581
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
22110742
uniprot
proteins
pubmed
22118770
uniprot
proteins
pubmed
24210661
uniprot
proteins
pubmed
29361558
uniprot
proteins
pubmed
32513959
uniprot
proteins
sequence_length
113
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UBF6}. Nucleus {ECO:0000250|UniProtKB:Q9UBF6}.
uniprot
proteins