Thap4
entrez
363291
canonical
uniprot
Q642B6
canonical
ensembl
ENSRNOG00000018351
resolver
ensembl
ENSRNOG00060009524
resolver
ensp
ENSRNOP00000024794
resolver
ensp
ENSRNOP00060012604
resolver
enst
ENSRNOT00000024794
resolver
enst
ENSRNOT00060016111
resolver
genesymbol
Thap4
resolver
uniprot_entry
THAP4_RAT
resolver
amino_acid_sequence
MVICCAAVNCSNRQGKGEKRAVSFHRFPLKDSKRLIQWLKAVQRDNWTPTKYSFLCSEHFTKDSFSKRLEDQHRLLKPTAVPSIFHLSEKKRGAGGHGPARRKTTGAMRGHTSAATGKGTIGSSLSSSDNLMAKPESRKLKRASPQDDTAPKATPGAVSQEPGQSLERTPGDQAAPLARGQEEAQVSATEADHQKASSSAADAGGADKSGISMDDFTPPGSGACKFIGSLHSYSFSSKHTRERPSVPREPMDRKRLKRDIEPRCSGNSVAQSPPSSSLTATPQKASQSPSAPPTDVTPKPAAEAVQSEHSDANPMSINEVILSASGACKLIDSLHSYCFSARQNKSQVCCLREQVEKKNGELKSLRQRVSRSDSQVRKLREKLDELRRASLPYLPYLSGLLPPSHEPPKLNPVVEPLSWMLGTWLSEPPGVGTFPTLQPFQYLEEVHISHVGQPMLNFSFNSFHPETHKPMHRECGFIRLKPDTNKVAFVSAQNTGVVEVEEGEVNGQELCVSSHSISRISFAKEPHVQQITRKFRLNSEGKLEQTVSMATTTQPMTQHLHITYKKVTP
uniprot
proteins
ec_number
5.99.-.-
uniprot
proteins
function
FUNCTION: Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo, possibly modulating the transcriptional activity residing in the N-terminal region. {ECO:0000250|UniProtKB:Q8WY91}.
uniprot
proteins
mass_dalton
62407
uniprot
proteins
pathway_participation
PATHWAY: Nitrogen metabolism. {ECO:0000250|UniProtKB:Q8WY91}.
uniprot
proteins
protein_family
Nitrobindin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
569
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8WY91}. Nucleus {ECO:0000250|UniProtKB:Q8WY91}. Note=Localizes mainly in the cytoplasm and partially in the nucleus. {ECO:0000250|UniProtKB:Q8WY91}.
uniprot
proteins