Rtn4rl2
entrez
269295
canonical
uniprot
Q7M6Z0
canonical
ensembl
ENSMUSG00000050896
resolver
ensp
ENSMUSP00000057725
resolver
enst
ENSMUST00000054514
resolver
genesymbol
Rtn4rl2
resolver
genesymbol_syn
Ngrl3
resolver
uniprot
A2RTJ0
resolver
uniprot
Q3UQ62
resolver
uniprot_entry
R4RL2_MOUSE
resolver
uniprot_sec
A2RTJ0
resolver
uniprot_sec
Q3UQ62
resolver
amino_acid_sequence
MLPGLRRLLQGPASACLLLTLLALPSVTPSCPMLCTCYSSPPTVSCQANNFSSVPLSLPPSTQRLFLQNNLIRSLRPGTFGPNLLTLWLFSNNLSTIHPGTFRHLQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFHGLSRLTILYLFNNSLASLPGEALADLPALEFLRLNANPWACDCRARPLWAWFQRARVSSSDVTCATPPERQGRDLRALRDSDFQACPPPTPTRPGSRARGNSSSNHLYGVAEAGAPPADPSTLYRDLPAEDSRGRQGGDAPTEDDYWGGYGGEDQRGEQTCPGAACQAPADSRGPALSAGLRTPLLCLLPLALHHL
uniprot
proteins
function
FUNCTION: Cell surface receptor that plays a functionally redundant role in the inhibition of neurite outgrowth mediated by MAG (By similarity). Plays a functionally redundant role in postnatal brain development (PubMed:27339102). Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum (PubMed:27339102). Does not seem to play a significant role in regulating axon regeneration in the adult central nervous system (PubMed:22406547). Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG (PubMed:26335717). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200). {ECO:0000250|UniProtKB:Q80WD1, ECO:0000269|PubMed:22325200, ECO:0000269|PubMed:22406547, ECO:0000269|PubMed:26335717, ECO:0000269|PubMed:27339102}.
uniprot
proteins
mass_dalton
46075
uniprot
proteins
post_translational_modification
PTM: Undergoes zinc metalloproteinase-mediated ectodomain shedding in neuroblastoma cells; is released both as a full-length ectodomain and an N-terminal fragment containing the leucine-rich repeat (LRR) region of the protein. {ECO:0000250|UniProtKB:Q86UN3}.; PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q86UN3}.
uniprot
proteins
protein_family
Nogo receptor family
uniprot
proteins
pubmed
12839991
uniprot
proteins
pubmed
14664809
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15673660
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19367338
uniprot
proteins
pubmed
22325200
uniprot
proteins
pubmed
22406547
uniprot
proteins
pubmed
26335717
uniprot
proteins
pubmed
27339102
uniprot
proteins
sequence_length
420
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q86UN3}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q86UN3}. Membrane raft {ECO:0000250|UniProtKB:Q80WD1}. Cell projection, dendrite {ECO:0000269|PubMed:22325200}. Cell projection, axon {ECO:0000269|PubMed:22325200}. Perikaryon {ECO:0000250|UniProtKB:Q80WD1}. Note=Localized to the surface of neurons, including axons. Detected close to synapses, but is excluded from synapses. {ECO:0000269|PubMed:22325200}.
uniprot
proteins