PDE1C
entrez
5137
canonical
uniprot
Q14123
canonical
ensembl
ENSG00000154678
resolver
ensp
ENSP00000318105
resolver
ensp
ENSP00000379485
resolver
ensp
ENSP00000379487
resolver
ensp
ENSP00000379494
resolver
ensp
ENSP00000379496
resolver
ensp
ENSP00000526516
resolver
ensp
ENSP00000622533
resolver
ensp
ENSP00000670744
resolver
ensp
ENSP00000715538
resolver
ensp
ENSP00000715552
resolver
enst
ENST00000396193
resolver
genesymbol
PDE1C
resolver
hgnc
HGNC:8776
resolver
uniprot
A0A0A0MS69
resolver
uniprot
B3KPC6
resolver
uniprot
E9PE92
resolver
uniprot
Q14124
resolver
uniprot
Q8NB10
resolver
uniprot_entry
A0A0A0MS69_HUMAN
resolver
uniprot_entry
PDE1C_HUMAN
resolver
uniprot_sec
B3KPC6
resolver
uniprot_sec
E9PE92
resolver
uniprot_sec
Q14124
resolver
uniprot_sec
Q8NB10
resolver
activity_regulation
ACTIVITY REGULATION: Type I PDE are activated by the binding of calmodulin in the presence of Ca(2+). {ECO:0000250|UniProtKB:Q64338}.
uniprot
proteins
amino_acid_sequence
MESPTKEIEEFESNSLKYLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIEALKDVDKWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQDDEEMNILINLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDETSQTGGTGQRRSSLNSISSSDAKRSGVKTSGSEGSAPINNSVISVDYKSFKATWTEVVHINRERWRAKVPKEEKAKKEAEEKARLAAEEQQKEMEAKSQAEEGASGKAEKKTSGETKNQVNGTRANKSDNPRGKNSKAEKSSGEQQQNGDFKDGKNKTDKKDHSNIGNDSKKTDGTKQRSHGSPAPSTSSTCRLTLPVIKPPLRHFKRPAYASSSYAPSVSKKTDEHPARYKMLDQRIKMKKIQNISHNWNRK
uniprot
proteins
disease_involvement
DISEASE: Deafness, autosomal dominant, 74 (DFNA74) [MIM:618140]: A form of non-syndromic deafness characterized by progressive, postlingual hearing loss with onset in the third decade of life. {ECO:0000269|PubMed:29860631}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.1.4.17
uniprot
proteins
function
FUNCTION: Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:29860631, PubMed:8557689). Has a high affinity for both cAMP and cGMP (PubMed:8557689). Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable). In kidney juxtaglomerular granular cells, inhibits renin release by decreasing cAMP levels (By similarity). {ECO:0000250|UniProtKB:Q64338, ECO:0000269|PubMed:29860631, ECO:0000269|PubMed:8557689, ECO:0000305|PubMed:29860631}.
uniprot
proteins
mass_dalton
80760
uniprot
proteins
protein_family
Cyclic nucleotide phosphodiesterase family
uniprot
proteins
protein_family
PDE1 subfamily
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
29860631
uniprot
proteins
pubmed
8557689
uniprot
proteins
sequence_length
709
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:Q64338}.
uniprot
proteins