MARCHF1
entrez
55016
canonical
uniprot
Q8TCQ1
canonical
ensembl
ENSG00000145416
resolver
ensp
ENSP00000274056
resolver
ensp
ENSP00000345676
resolver
ensp
ENSP00000421322
resolver
ensp
ENSP00000427223
resolver
enst
ENST00000514618
resolver
genesymbol
MARCHF1
resolver
genesymbol_syn
MARCH1
resolver
genesymbol_syn
RNF171
resolver
hgnc
HGNC:26077
resolver
uniprot
A8K0Z6
resolver
uniprot
D3DP29
resolver
uniprot
D6RGC4
resolver
uniprot
Q9NWR0
resolver
uniprot_entry
A8K0Z6_HUMAN
resolver
uniprot_entry
D6RGC4_HUMAN
resolver
uniprot_entry
MARH1_HUMAN
resolver
uniprot_sec
D3DP29
resolver
uniprot_sec
Q9NWR0
resolver
amino_acid_sequence
MLGWCEAIARNPHRIPNNTRTPEISGDLADASQTSTLNEKSPGRSASRSSNISKASSPTTGTAPRSQSRLSVCPSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDTRCCELCKYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRTAEEIKQGNDNGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQNCPDTAKKLEKNFSCNVNTDIKDAVVVPVPQTGANSLPSAEGGPPEVVSV
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies (PubMed:18389477, PubMed:18305173, PubMed:21220452, PubMed:35045264). By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, down-regulates their cell surface localization thus sequestering them in the intracellular endosomal system. Also regulates insulin sensitivity by controlling surface expression of the insulin receptor subunit beta/INSR by direct ubiquitination and degradation (PubMed:27577745). {ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:18305173, ECO:0000269|PubMed:18389477, ECO:0000269|PubMed:19117940, ECO:0000269|PubMed:21220452, ECO:0000269|PubMed:27577745, ECO:0000269|PubMed:35045264}.; FUNCTION: (Microbial infection) Plays a role in iron metabolism by regulating the levels of the transferrin receptor TFRC during human cytomegalovirus infection, subsequently contributing to a proviral effect. {ECO:0000269|PubMed:35045264}.
uniprot
proteins
mass_dalton
32308
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated via ubiquitin-conjugating enzyme E2 D1/UBE2D1 independently of lysines, leading to proteolytic degradation. {ECO:0000269|PubMed:29414787}.; PTM: Has a short half-life. Instability/short half-life permits rapid changes that allow efficient induction of antigen presentation once antigen presenting cells, APCs, receive maturation signals. Small changes in protein levels significantly alter the cell surface display of MHC class II proteins (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14722266
uniprot
proteins
pubmed
17255932
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18305173
uniprot
proteins
pubmed
18389477
uniprot
proteins
pubmed
19117940
uniprot
proteins
pubmed
21220452
uniprot
proteins
pubmed
27577745
uniprot
proteins
pubmed
29414787
uniprot
proteins
pubmed
35045264
uniprot
proteins
sequence_length
289
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q6NZQ8}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:14722266}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:19117940}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:14722266, ECO:0000269|PubMed:19117940}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:19117940}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 155..175; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 197..217; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins