TEM5
entrez
25960
canonical
uniprot
Q96PE1
canonical
ensembl
ENSG00000020181
resolver
ensp
ENSP00000406367
resolver
ensp
ENSP00000545501
resolver
ensp
ENSP00000617469
resolver
genesymbol
ADGRA2
resolver
genesymbol
TEM5
resolver
genesymbol_syn
GPR124
resolver
genesymbol_syn
KIAA1531
resolver
genesymbol_syn
TEM5
resolver
hgnc
HGNC:17849
resolver
uniprot
A6H8W3
resolver
uniprot
D3DSW4
resolver
uniprot
Q6YN44
resolver
uniprot
Q8N3R1
resolver
uniprot
Q8TEM3
resolver
uniprot
Q96KB2
resolver
uniprot
Q9P1Z7
resolver
uniprot
Q9UFY4
resolver
uniprot_entry
AGRA2_HUMAN
resolver
uniprot_entry
Q6YN44_HUMAN
resolver
uniprot_sec
A6H8W3
resolver
uniprot_sec
D3DSW4
resolver
uniprot_sec
Q8N3R1
resolver
uniprot_sec
Q8TEM3
resolver
uniprot_sec
Q96KB2
resolver
uniprot_sec
Q9P1Z7
resolver
uniprot_sec
Q9UFY4
resolver
amino_acid_sequence
MGAGGRRMRGAPARLLLPLLPWLLLLLAPEARGAPGCPLSIRSCKCSGERPKGLSGGVPGPARRRVVCSGGDLPEPPEPGLLPNGTVTLLLSNNKITGLRNGSFLGLSLLEKLDLRNNIISTVQPGAFLGLGELKRLDLSNNRIGCLTSETFQGLPRLLRLNISGNIFSSLQPGVFDELPALKVVDLGTEFLTCDCHLRWLLPWAQNRSLQLSEHTLCAYPSALHAQALGSLQEAQLCCEGALELHTHHLIPSLRQVVFQGDRLPFQCSASYLGNDTRIRWYHNRAPVEGDEQAGILLAESLIHDCTFITSELTLSHIGVWASGEWECTVSMAQGNASKKVEIVVLETSASYCPAERVANNRGDFRWPRTLAGITAYQSCLQYPFTSVPLGGGAPGTRASRRCDRAGRWEPGDYSHCLYTNDITRVLYTFVLMPINASNALTLAHQLRVYTAEAASFSDMMDVVYVAQMIQKFLGYVDQIKELVEVMVDMASNLMLVDEHLLWLAQREDKACSRIVGALERIGGAALSPHAQHISVNARNVALEAYLIKPHSYVGLTCTAFQRREGGVPGTRPGSPGQNPPPEPEPPADQQLRFRCTTGRPNVSLSSFHIKNSVALASIQLPPSLFSSLPAALAPPVPPDCTLQLLVFRNGRLFHSHSNTSRPGAAGPGKRRGVATPVIFAGTSGCGVGNLTEPVAVSLRHWAEGAEPVAAWWSQEGPGEAGGWTSEGCQLRSSQPNVSALHCQHLGNVAVLMELSAFPREVGGAGAGLHPVVYPCTALLLLCLFATIITYILNHSSIRVSRKGWHMLLNLCFHIAMTSAVFAGGITLTNYQMVCQAVGITLHYSSLSTLLWMGVKARVLHKELTWRAPPPQEGDPALPTPSPMLRFYLIAGGIPLIICGITAAVNIHNYRDHSPYCWLVWRPSLGAFYIPVALILLITWIYFLCAGLRLRGPLAQNPKAGNSRASLEAGEELRGSTRLRGSGPLLSDSGSLLATGSARVGTPGPPEDGDSLYSPGVQLGALVTTHFLYLAMWACGALAVSQRWLPRVVCSCLYGVAASALGLFVFTHHCARRRDVRASWRACCPPASPAAPHAPPRALPAAAEDGSPVFGEGPPSLKSSPSGSSGHPLALGPCKLTNLQLAQSQVCEAGAAAGGEGEPEPAGTRGNLAHRHPNNVHHGRRAHKSRAKGHRAGEACGKNRLKALRGGAAGALELLSSESGSLHNSPTDSYLGSSRNSPGAGLQLEGEPMLTPSEGSDTSAAPLSEAGRAGQRRSASRDSLKGGGALEKESHRRSYPLNAASLNGAPKGGKYDDVTLMGAEVASGGCMKTGLWKSETTV
uniprot
proteins
function
FUNCTION: Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). ADGRA2-tethering function does not rely on its G protein-coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed:30026314). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628). {ECO:0000250|UniProtKB:Q91ZV8, ECO:0000269|PubMed:16982628, ECO:0000269|PubMed:28289266, ECO:0000269|PubMed:30026314}.
uniprot
proteins
mass_dalton
142647
uniprot
proteins
mutagenesis
MUTAGEN 369; /note="R->A: Minimal effect on thrombin cleavage. Abolishes thrombin cleavage; when associated with G-398."; /evidence="ECO:0000269|PubMed:22013897"; MUTAGEN 398; /note="R->G: Minimal effect on thrombin cleavage. Abolishes thrombin cleavage; when associated with A-369."; /evidence="ECO:0000269|PubMed:22013897"; MUTAGEN 1335..1338; /note="Missing: Fails to interact with DLG1."; /evidence="ECO:0000269|PubMed:15021905
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:21421844}.; PTM: Proteolytically cleaved into two subunits, an extracellular subunit and a seven-transmembrane subunit (PubMed:16982628, PubMed:22013897). Cleaved by thrombin (F2) and MMP1 (PubMed:22013897). Also cleaved by MMP9, with lower efficiency (PubMed:16982628, PubMed:22013897). Presence of the protein disulfide-isomerase P4HB at the cell surface is additionally required for shedding of the extracellular subunit, suggesting that the subunits are linked by disulfide bonds (PubMed:22013897). Shedding is enhanced by the growth factor FGF2 and may promote cell survival during angiogenesis (PubMed:16982628). {ECO:0000269|PubMed:16982628, ECO:0000269|PubMed:22013897}.
uniprot
proteins
protein_family
Adhesion G protein-coupled receptor (ADGR) subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 2 family
uniprot
proteins
pubmed
10819331
uniprot
proteins
pubmed
11559528
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
12565841
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15021905
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
16982628
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21421844
uniprot
proteins
pubmed
22013897
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24501278
uniprot
proteins
pubmed
24925318
uniprot
proteins
pubmed
28289266
uniprot
proteins
pubmed
30026314
uniprot
proteins
sequence_length
1338
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16982628, ECO:0000269|PubMed:21421844, ECO:0000269|PubMed:22013897}; Multi-pass membrane protein {ECO:0000255}. Cell projection, filopodium {ECO:0000269|PubMed:21421844}. Note=Enriched at lateral cell borders and also at sites of cell-ECM (extracellular matrix) contact. {ECO:0000269|PubMed:21421844}.
uniprot
proteins
transmembrane_region
TRANSMEM 772..792; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 808..828; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 833..853; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 887..907; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 925..945; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 1020..1040; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 1048..1068; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins