NOX4
entrez
50507
canonical
uniprot
Q9NPH5
canonical
ensembl
ENSG00000086991
resolver
ensp
ENSP00000263317
resolver
ensp
ENSP00000433797
resolver
ensp
ENSP00000434924
resolver
ensp
ENSP00000436892
resolver
ensp
ENSP00000436970
resolver
enst
ENST00000528341
resolver
genesymbol
NOX4
resolver
genesymbol_syn
RENOX
resolver
hgnc
HGNC:7891
resolver
uniprot
A8K715
resolver
uniprot
B3KQ17
resolver
uniprot
B7Z520
resolver
uniprot
B7Z523
resolver
uniprot
B7Z529
resolver
uniprot
E7EMD7
resolver
uniprot
E9PPP2
resolver
uniprot
Q5K3R4
resolver
uniprot
Q5K3R5
resolver
uniprot
Q5K3R6
resolver
uniprot
Q5K3R8
resolver
uniprot
Q7Z7G3
resolver
uniprot
Q86V92
resolver
uniprot_entry
B3KQ17_HUMAN
resolver
uniprot_entry
B7Z523_HUMAN
resolver
uniprot_entry
B7Z529_HUMAN
resolver
uniprot_entry
E9PPP2_HUMAN
resolver
uniprot_entry
NOX4_HUMAN
resolver
uniprot_sec
A8K715
resolver
uniprot_sec
B7Z520
resolver
uniprot_sec
E7EMD7
resolver
uniprot_sec
Q5K3R4
resolver
uniprot_sec
Q5K3R5
resolver
uniprot_sec
Q5K3R6
resolver
uniprot_sec
Q5K3R8
resolver
uniprot_sec
Q7Z7G3
resolver
uniprot_sec
Q86V92
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by plumbagin (By similarity). Activated by phorbol 12-myristate 13-acetate (PMA). Activated by insulin. Inhibited by diphenylene iodonium. {ECO:0000250|UniProtKB:Q9JHI8, ECO:0000269|PubMed:14966267, ECO:0000269|PubMed:15572675, ECO:0000269|PubMed:16019190, ECO:0000269|PubMed:16324151}.
uniprot
proteins
amino_acid_sequence
MAVSWRSWLANEGVKHLCLFIWLSMNVLLFWKTFLLYNQGPEYHYLHQMLGLGLCLSRASASVLNLNCSLILLPMCRTLLAYLRGSQKVPSRRTRRLLDKSRTFHITCGVTICIFSGVHVAAHLVNALNFSVNYSEDFVELNAARYRDEDPRKLLFTTVPGLTGVCMVVVLFLMITASTYAIRVSNYDIFWYTHNLFFVFYMLLTLHVSGGLLKYQTNLDTHPPGCISLNRTSSQNISLPEYFSEHFHEPFPEGFSKPAEFTQHKFVKICMEEPRFQANFPQTWLWISGPLCLYCAERLYRYIRSNKPVTIISVMSHPSDVMEIRMVKENFKARPGQYITLHCPSVSALENHPFTLTMCPTETKATFGVHLKIVGDWTERFRDLLLPPSSQDSEILPFIQSRNYPKLYIDGPFGSPFEESLNYEVSLCVAGGIGVTPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSFRWFADLLCMLHNKFWQENRPDYVNIQLYLSQTDGIQKIIGEKYHALNSRLFIGRPRWKLLFDEIAKYNRGKTVGVFCCGPNSLSKTLHKLSNQNNSYGTRFEYNKESFS
uniprot
proteins
ec_number
1.6.3.1
uniprot
proteins
function
FUNCTION: NADPH oxidase that catalyzes predominantly the reduction of oxygen to H2O2 (PubMed:14966267, PubMed:15356101, PubMed:15927447, PubMed:21343298, PubMed:25062272). Can also catalyze to a smaller extent, the reduction of oxygen to superoxide (PubMed:10869423, PubMed:11032835, PubMed:15155719, PubMed:15572675, PubMed:15927447, PubMed:16019190, PubMed:16179589, PubMed:16230378, PubMed:16324151, PubMed:25062272). May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity (PubMed:16019190). May regulate insulin signaling cascade (PubMed:14966267). May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB (PubMed:15356101, PubMed:15572675). May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation (PubMed:16324151). Promotes ferroptosis, reactive oxygen species production and reduced glutathione (GSH) levels by activating NLRP3 inflammasome activation and cytokine release (PubMed:39909992). {ECO:0000269|PubMed:10869423, ECO:0000269|PubMed:11032835, ECO:0000269|PubMed:14966267, ECO:0000269|PubMed:15155719, ECO:0000269|PubMed:15356101, ECO:0000269|PubMed:15572675, ECO:0000269|PubMed:15927447, ECO:0000269|PubMed:16019190, ECO:0000269|PubMed:16179589, ECO:0000269|PubMed:16230378, ECO:0000269|PubMed:16324151, ECO:0000269|PubMed:21343298, ECO:0000269|PubMed:25062272, ECO:0000269|PubMed:39909992}.; FUNCTION: [Isoform 4]: NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed:15721269, PubMed:23393389). Involved in redox signaling in vascular cells (PubMed:23393389). Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage (PubMed:23393389). {ECO:0000269|PubMed:15721269, ECO:0000269|PubMed:23393389}.; FUNCTION: [Isoform 3]: Lacks superoxide-generating NADPH oxidase activity. {ECO:0000269|PubMed:15721269}.
uniprot
proteins
mass_dalton
66932
uniprot
proteins
mutagenesis
MUTAGEN 16; /note="H->Q: 50% reduction in H2O2 generation, without any effect on superoxide generation."; /evidence="ECO:0000269|PubMed:21343298"; MUTAGEN 47; /note="H->Q: No effect on H2O2 or superoxide generation."; /evidence="ECO:0000269|PubMed:21343298"; MUTAGEN 218..235; /note="Missing: Loss of H2O2 generation with predominant generation of superoxide. No effect on localization to the endoplasmic reticulum."; /evidence="ECO:0000269|PubMed:21343298"; MUTAGEN 222; /note="H->Q: Loss of H2O2 generation with predominant generation of superoxide."; /evidence="ECO:0000269|PubMed:21343298, ECO:0000269|PubMed:25062272"; MUTAGEN 226; /note="C->V: Loss of H2O2 generation with predominant generation of superoxide."; /evidence="ECO:0000269|PubMed:21343298"; MUTAGEN 246; /note="H->Q: No effect on H2O2 or superoxide generation."; /evidence="ECO:0000269|PubMed:21343298"; MUTAGEN 248; /note="H->Q: No effect on H2O2 or superoxide generation."; /evidence="ECO:0000269|PubMed:21343298"; MUTAGEN 264..273; /note="Missing: Loss of H2O2 generation with predominant generation of superoxide. No effect on localization to the endoplasmic reticulum."; /evidence="ECO:0000269|PubMed:21343298"; MUTAGEN 270; /note="C->V: Loss of H2O2 generation with predominant generation of superoxide."; /evidence="ECO:0000269|PubMed:21343298"; MUTAGEN 304; /note="R->RGT: Partial loss of catalytic activity. No effect on CYBA localization."; /evidence="ECO:0000269|PubMed:15927447"; MUTAGEN 575..578; /note="Missing: Partial loss of catalytic activity. No effect on CYBA localization."; /evidence="ECO:0000269|PubMed:15927447
uniprot
proteins
post_translational_modification
PTM: Deubiquitinated by USP19. {ECO:0000269|PubMed:38943386}.; PTM: [Isoform 4]: N-glycosylated and glycosylation is required for its proper function. {ECO:0000269|PubMed:15721269}.; PTM: [Isoform 3]: N-glycosylated. {ECO:0000269|PubMed:15721269}.
uniprot
proteins
pubmed
10869423
uniprot
proteins
pubmed
11032835
uniprot
proteins
pubmed
11376945
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14966267
uniprot
proteins
pubmed
15155719
uniprot
proteins
pubmed
15210697
uniprot
proteins
pubmed
15356101
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15572675
uniprot
proteins
pubmed
15721269
uniprot
proteins
pubmed
15927447
uniprot
proteins
pubmed
16019190
uniprot
proteins
pubmed
16179589
uniprot
proteins
pubmed
16230378
uniprot
proteins
pubmed
16324151
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
21343298
uniprot
proteins
pubmed
23393389
uniprot
proteins
pubmed
25062272
uniprot
proteins
pubmed
26742780
uniprot
proteins
pubmed
38943386
uniprot
proteins
pubmed
39909992
uniprot
proteins
sequence_length
578
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:39909992}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:15572675, ECO:0000269|PubMed:15927447, ECO:0000269|PubMed:21343298, ECO:0000269|PubMed:26742780}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:16019190, ECO:0000269|PubMed:21343298}; Multi-pass membrane protein {ECO:0000255}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q924V1}. Nucleus {ECO:0000269|PubMed:16324151}.; SUBCELLULAR LOCATION: [Isoform 4]: Nucleus {ECO:0000269|PubMed:23393389}. Nucleus, nucleolus {ECO:0000269|PubMed:23393389}. Cytoplasm {ECO:0000269|PubMed:15721269}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15721269}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:15721269}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15721269}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:15721269}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15721269}.; SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm {ECO:0000269|PubMed:15721269}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15721269}.
uniprot
proteins
transmembrane_region
TRANSMEM 17..37; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 63..83; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 104..124; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 155..175; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 189..209; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 425..445; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins