Pla2g3
entrez
237625
canonical
uniprot
Q8BZT7
canonical
ensembl
ENSMUSG00000034579
resolver
ensp
ENSMUSP00000068699
resolver
ensp
ENSMUSP00000279137
resolver
ensp
ENSMUSP00000279138
resolver
ensp
ENSMUSP00000279140
resolver
enst
ENSMUST00000064265
resolver
genesymbol
Pla2g3
resolver
uniprot
Q6AXH0
resolver
uniprot_entry
PA2G3_MOUSE
resolver
uniprot_entry
Q6AXH0_MOUSE
resolver
amino_acid_sequence
MGVLGVLLGVLAFLEGSHTRHWDSTSCHLVQPIPGNPLGSLSFLGKDAQGLALFQAFWDTHHRLQVCIRQDESELITAFRALCAHEPLQHSFIQTPGPALQRALATLQSQWEACQRSQDSPTGAREKRAIEQSGAPDREHRRRRRGWTIPGTLWCGVGNSAENASELGVFHGPDLCCREHDQCPQTISPLQYNYGIRNFRFHTISHCDCDARFQQCLRSQGDSISDIMGVAFFNVLEIPCFVLKEQEACVAWNWWGGCRAYGSTPLAHLRPRTYYNASWKAEATSYTPSPQSPAPSKHPQKRGPQQTQARRHSTTTTTPFQTPAISSRPDMIPRGQPGVPHLGFQDGPKHQSAHRVCRSLRHLDQCEHQIKPQETKFHLLNSAQMPLFHCDCTRRLARFLRLHSPPAGTDKVWDLLGTTCFKLAPQLDCAEGKGCSRDHRAIKVSARHLQRLHKSRLHFRDKGTGGALAQPVEPPGSTMSFYSQCLQVTQAIWRRRGQKKFWSS
uniprot
proteins
ec_number
3.1.1.4
uniprot
proteins
function
FUNCTION: Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids without apparent head group selectivity (PubMed:20424323). Contributes to phospholipid remodeling of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles. Hydrolyzes LDL phospholipids releasing unsaturated fatty acids that regulate macrophage differentiation toward foam cells (By similarity). May act in an autocrine and paracrine manner (PubMed:23624557). Secreted by immature mast cells, acts on nearby fibroblasts upstream to PTDGS to synthesize prostaglandin D2 (PGD2), which in turn promotes mast cell maturation and degranulation via PTGDR (PubMed:23624557). Secreted by epididymal epithelium, acts on immature sperm cells within the duct, modulating the degree of unsaturation of the fatty acyl components of phosphatidylcholines required for acrosome assembly and sperm cell motility (PubMed:20424323). Facilitates the replacement of fatty acyl chains in phosphatidylcholines in sperm membranes from omega-6 and omega-9 to omega-3 polyunsaturated fatty acids (PUFAs) (PubMed:20424323). Coupled to lipoxygenase pathway, may process omega-6 PUFAs to generate oxygenated lipid mediators in the male reproductive tract (PubMed:20424323). At pericentrosomal preciliary compartment, negatively regulates ciliogenesis likely by regulating endocytotic recycling of ciliary membrane protein (By similarity). Coupled to cyclooxygenase pathway provides arachidonate to generate prostaglandin E2 (PGE2), a potent immunomodulatory lipid in inflammation and tumorigenesis (By similarity). At colonic epithelial barrier, preferentially hydrolyzes phospholipids having arachidonate and docosahexaenoate at sn-2 position, contributing to the generation of oxygenated metabolites involved in colonic stem cell homeostasis (PubMed:28947740). Releases C16:0 and C18:0 lysophosphatidylcholine subclasses from neuron plasma membranes and promotes neurite outgrowth and neuron survival (PubMed:17868035). {ECO:0000250|UniProtKB:Q9NZ20, ECO:0000269|PubMed:17868035, ECO:0000269|PubMed:20424323, ECO:0000269|PubMed:23624557, ECO:0000269|PubMed:28947740}.
uniprot
proteins
mass_dalton
56687
uniprot
proteins
post_translational_modification
PTM: N-glycosylation does not affect the catalytic activity, but is required for proper secretion. A nonglycosylated form is observed in several cell types. {ECO:0000250|UniProtKB:Q9NZ20}.; PTM: In several cell types, the N- and C-termini are cleaved off. {ECO:0000250|UniProtKB:Q9NZ20}.
uniprot
proteins
protein_family
Phospholipase A2 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17868035
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20424323
uniprot
proteins
pubmed
23624557
uniprot
proteins
pubmed
28947740
uniprot
proteins
sequence_length
504
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9NZ20}. Cell membrane {ECO:0000250|UniProtKB:Q9NZ20}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q9NZ20}. Recycling endosome {ECO:0000250|UniProtKB:Q9NZ20}. Note=Localized at pericentrosomal preciliary compartment. {ECO:0000250|UniProtKB:Q9NZ20}.
uniprot
proteins