PABIR1
entrez
116224
canonical
uniprot
Q96E09
canonical
ensembl
ENSG00000187866
resolver
ensp
ENSP00000377807
resolver
enst
ENST00000394264
resolver
genesymbol
PABIR1
resolver
genesymbol_syn
C9orf42
resolver
genesymbol_syn
FAM122A
resolver
hgnc
HGNC:23490
resolver
uniprot
B3KX07
resolver
uniprot_entry
B3KX07_HUMAN
resolver
uniprot_entry
PBIR1_HUMAN
resolver
amino_acid_sequence
MAQEKMELDLELPPGTGGSPAEGGGSGGGGGLRRSNSAPLIHGLSDTSPVFQAEAPSARRNSTTFPSRHGLLLPASPVRMHSSRLHQIKQEEGMDLINRETVHEREVQTAMQISHSWEESFSLSDNDVEKSASPKRIDFIPVSPAPSPTRGIGKQCFSPSLQSFVSSNGLPPSPIPSPTTRFTTRRSQSPINCIRPSVLGPLKRKCEMETEYQPKRFFQGITNMLSSDVAQLSDPGVCVSSDTLDGNSSSAGSSCNSPAKVSTTTDSPVSPAQAASPFIPLDELSSK
uniprot
proteins
function
FUNCTION: Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity (PubMed:27588481, PubMed:33108758, PubMed:38123684). Inhibits PP2A activity by blocking the substrate binding site on PPP2R2A and the active site of PPP2CA (PubMed:38123684). Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) (PubMed:27588481). Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby releasing G2/M checkpoint (PubMed:33108758). {ECO:0000269|PubMed:27588481, ECO:0000269|PubMed:33108758, ECO:0000269|PubMed:38123684}.
uniprot
proteins
mass_dalton
30529
uniprot
proteins
mutagenesis
MUTAGEN 37; /note="S->A: Loss of phosphorylation and interaction with 14-3-3 proteins. Enhanced interaction with PPP2R2A."; /evidence="ECO:0000269|PubMed:33108758"; MUTAGEN 84..85; /note="RL->AA: Impairs interaction with PPP2R2A and reduces the inhibition of PP2A activity by PABIR1/FAM122A."; /evidence="ECO:0000269|PubMed:38123684"; MUTAGEN 88..89; /note="IK->AA: Impairs interaction with PPP2R2A and reduces the inhibition of PP2A activity by PABIR1/FAM122A."; /evidence="ECO:0000269|PubMed:38123684"; MUTAGEN 91; /note="E->K: Impairs interaction with PPP2R2A and reduces the inhibition of PP2A activity by PABIR1/FAM122A."; /evidence="ECO:0000269|PubMed:38123684"; MUTAGEN 92; /note="E->K: Impairs interaction with PPP2R2A and reduces the inhibition of PP2A activity by PABIR1/FAM122A."; /evidence="ECO:0000269|PubMed:38123684"; MUTAGEN 105; /note="R->L: Reduces the inhibition of PP2A activity by PABIR1/FAM122A."; /evidence="ECO:0000269|PubMed:38123684"; MUTAGEN 107; /note="V->G: Reduces the inhibition of PP2A activity by PABIR1/FAM122A."; /evidence="ECO:0000269|PubMed:38123684
uniprot
proteins
post_translational_modification
PTM: CHEK1-mediated phosphorylation at Ser-37 negatively regulates its ability to inhibit serine/threonine-protein phosphatase 2A (PP2A) activity. Phosphorylation leads to its release from the PP2A complex and its sequestration by 14-3-3 proteins in the cytoplasm resulting in its inability to translocate to the nucleus, where it otherwise inhibits PP2A. {ECO:0000269|PubMed:33108758}.
uniprot
proteins
protein_family
FAM122 family
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
27588481
uniprot
proteins
pubmed
33108758
uniprot
proteins
pubmed
38123684
uniprot
proteins
sequence_length
287
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:33108758}. Cytoplasm {ECO:0000269|PubMed:33108758}. Note=The CHEK1-mediated Ser-37 phosphorylated form is sequestered by 14-3-3 proteins in the cytoplasm and fails to translocate to the nucleus, where it otherwise inhibits serine/threonine-protein phosphatase 2A. {ECO:0000269|PubMed:33108758}.
uniprot
proteins