Gspt1
entrez
14852
canonical
uniprot
Q8R050
canonical
ensembl
ENSMUSG00000062203
resolver
ensp
ENSMUSP00000078940
resolver
ensp
ENSMUSP00000130583
resolver
genesymbol
Gspt1
resolver
genesymbol_syn
Erf3a
resolver
uniprot
E9QK49
resolver
uniprot
G3UWC0
resolver
uniprot
O88179
resolver
uniprot
Q8CCV1
resolver
uniprot
Q8K2E1
resolver
uniprot_entry
ERF3A_MOUSE
resolver
uniprot_entry
Q8CCV1_MOUSE
resolver
uniprot_sec
E9QK49
resolver
uniprot_sec
G3UWC0
resolver
uniprot_sec
O88179
resolver
uniprot_sec
Q8K2E1
resolver
amino_acid_sequence
MDPSSGGGGGGGGGGSSSSSDSAPDCWDQTDMEAPGPGPCGGGGSGSGSMAAVAEAQRENLSAAFSRQLNVNAKPFVPNVHAAEFVPSFLRGPAQPPLSPAGAAGGDHGAGSGAGGPSEPVESSQDQSCEGSNSTVSMELSEPVVENGETEMSPEESWEHKEEISEAEPGGGSSGDGRPPEESTQEMMEEEEEIPKPKSAVAPPGAPKKEHVNVVFIGHVDAGKSTIGGQIMYLTGMVDKRTLEKYEREAKEKNRETWYLSWALDTNQEERDKGKTVEVGRAYFETEKKHFTILDAPGHKSFVPNMIGGASQADLAVLVISARKGEFETGFEKGGQTREHAMLAKTAGVKHLIVLINKMDDPTVNWSNERYEECKEKLVPFLKKVGFNPKKDIHFMPCSGLTGANLKEQSDFCPWYIGLPFIPYLDNLPNFNRSVDGPIRLPIVDKYKDMGTVVLGKLESGSICKGQQLVMMPNKHNVEVLGILSDDVETDSVAPGENLKIRLKGIEEEEILPGFILCDLNNLCHSGRTFDAQIVIIEHKSIICPGYNAVLHIHTCIEEVEITALICLVDKKSGEKSKTRPRFVKQDQVCIARLRTAGTICLETFKDFPQMGRFTLRDEGKTIAIGKVLKLVPEKD
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: GTPase component of the eRF1-eRF3-GTP ternary complex, a ternary complex that mediates translation termination in response to the termination codons UAA, UAG and UGA. GSPT1/ERF3A mediates ETF1/ERF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site. GTP hydrolysis by GSPT1/ERF3A induces a conformational change that leads to its dissociation, permitting ETF1/ERF1 to accommodate fully in the A-site. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Required for SHFL-mediated translation termination which inhibits programmed ribosomal frameshifting (-1PRF) of mRNA from viruses and cellular genes. {ECO:0000250|UniProtKB:P15170}.
uniprot
proteins
mass_dalton
68625
uniprot
proteins
protein_family
Classic translation factor GTPase family
uniprot
proteins
protein_family
ERF3 subfamily
uniprot
proteins
protein_family
TRAFAC class translation factor GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9712840
uniprot
proteins
sequence_length
636
uniprot
proteins