Icam5
entrez
15898
canonical
uniprot
Q60625
canonical
ensembl
ENSMUSG00000032174
resolver
ensp
ENSMUSP00000019616
resolver
enst
ENSMUST00000019616
resolver
genesymbol
Icam5
resolver
genesymbol_syn
Icam3
resolver
genesymbol_syn
Tlcn
resolver
uniprot
G5E826
resolver
uniprot
Q2KHL7
resolver
uniprot
Q3UY19
resolver
uniprot_entry
ICAM5_MOUSE
resolver
uniprot_sec
G5E826
resolver
uniprot_sec
Q2KHL7
resolver
uniprot_sec
Q3UY19
resolver
amino_acid_sequence
MPGPSPGLRRALLGLWAALGLGILGISAVALEPFWADLQPRVALVERGGSLWLNCSTNCPRPERGGLETSLRRNGTQRGLRWLARQLVDIREPETQPVCFFRCARRTLQARGLIRTFQRPDRVELVPLPSWQPVGENFTLSCRVPGAGPRASLTLTLLRGGQELIRRSFVGEPPRARGAMLTARVLARREDHRVNFSCLAELDLRPHGLGLFANSSAPRQLRTFAMPPHSPSLIAPRVLEVDSERPVTCTLDGLFPAPEAGVYLSLGDQRLNPNVTLDGDSLVATATATASAEQEGTKQLMCVVTLGGESRETQENLTVYSFPTPLLTLSEPEAPEGKMVTISCWAGARALVTLEGIPAAVPGQPAELQLNVTKNDDKRGFFCDAALDVDGETLRKNQSSELRVLYAPRLDDLDCPRSWTWPEGPEQTLHCEARGNPEPSVHCARPEGGAVLALGLLGPVTRALAGTYRCTAVNGQGQAVKDVTLTVEYAPALDSVGCPEHITWLEGTEASLSCVAHGVPPPSVSCVRSGKEEVMEGPLRVAREHAGTYRCEAINARGSAAKNVAVTVEYGPSFEELGCPSNWTWVEGSGKLFSCEVDGKPEPRVECVGSEGASEGIVLPLVSSNSGPRNSMTPGNLSPGIYLCNATNRHGSTVKTVVVSAESPPQMDESSCPSHQTWLEGAEATALACSARGRPSPRVHCSREGAARLERLQVSREDAGTYRCVATNAHGTDSRTVTVGVEYRPVVAELAASPPSVRPGGNFTLTCRAEAWPPAQISWRAPPGALNLGLSSNNSTLSVAGAMGSHGGEYECAATNAHGRHARRITVRVAGPWLWVAVGGAAGGAALLAAGAGLAFYVQSTACKKGEYNVQEAESSGEAVCLNGAGGTPGAEGGAETPGTAESPADGEVFAIQLTSS
uniprot
proteins
function
FUNCTION: Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring neuron cell-leukocyte adhesion (By similarity). Creates homophilic cell adhesion promoting dendritogenesis and arborization of hippocampal neurons (PubMed:22187327). {ECO:0000250|UniProtKB:A6JNN4, ECO:0000269|PubMed:22187327}.
uniprot
proteins
mass_dalton
96946
uniprot
proteins
mutagenesis
MUTAGEN 54; /note="N->Q: Impairs post-translational modification. Fails to form disulfide bonds. Impairs filopodia-like protrusions. Affects location at the membrane."; /evidence="ECO:0000269|PubMed:22187327
uniprot
proteins
post_translational_modification
PTM: Glycosylation at Asn-54 is critical for functional folding. {ECO:0000269|PubMed:22187327}.
uniprot
proteins
protein_family
ICAM family
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22187327
uniprot
proteins
pubmed
23897576
uniprot
proteins
pubmed
7794412
uniprot
proteins
pubmed
9244438
uniprot
proteins
sequence_length
917
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22187327}; Single-pass membrane protein {ECO:0000255}. Cell projection {ECO:0000250|UniProtKB:Q9UMF0}. Cell projection, uropodium {ECO:0000250|UniProtKB:Q9UMF0}. Cell projection, dendritic spine membrane {ECO:0000269|PubMed:23897576}. Note=At uropodium and cell-cell contact sites creates homophilic adhesion. {ECO:0000250|UniProtKB:Q9UMF0}.
uniprot
proteins
transmembrane_region
TRANSMEM 834..854; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins