Fscn1
entrez
683788
canonical
uniprot
P85845
canonical
ensembl
ENSRNOG00000056585
resolver
ensp
ENSRNOP00000093403
resolver
enst
ENSRNOT00000102305
resolver
genesymbol
Fscn1
resolver
uniprot
A0A8I6AK10
resolver
uniprot
B5DEI1
resolver
uniprot_entry
A0A8I6AK10_RAT
resolver
uniprot_entry
FSCN1_RAT
resolver
uniprot_sec
B5DEI1
resolver
amino_acid_sequence
MTANGTAEAVQIQFGLISCGNKYLTAEAFGFKVNASASSLKKKQIWTLEQPPDEAGSAAVCLRSHLGPYLAADKDGNVTCEREVPDGDCRFLVVAHDDGRWSLQSEAHRRYFGGTEDRLSCFAQSVSPAEKWSVHIAMHPQVNIYSVTRKRYAHLSARPADEIAVDRDVPWGVDSLITLAFQDQRYSVQTSDHRFLRHDGRLVARPEPATGFTLEFRSGKVAFRDCEGRYLAPSGPSGTLKAGKATKVGKDELFALEQSCAQVVLQAANERNVSTRQGMDLSANQDEETDQETFQLEIDRDTRKCAFRTHTGKYWTLTATGGVQSTASTKNASCYFDIEWCERRITLRASNGKFVTAKKNGQLAATVETAGDSELFLMKLINRPIIVFRGEHGFIGCRKVTGTLDANRSSYDVFQLEFNDGAYNIKDSTGKYWTVGSDSSVTSSSDTPVDFFLEFCDYNKVALKVGGRYLKGDHAGVLKACAETIDPATLWEY
uniprot
proteins
function
FUNCTION: Actin-binding protein that contains 2 major actin binding sites (PubMed:8769857). Organizes filamentous actin into parallel bundles (PubMed:8769857). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers. Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration. Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (By similarity). {ECO:0000250|UniProtKB:Q16658, ECO:0000269|PubMed:8769857}.
uniprot
proteins
mass_dalton
54491
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-39 inhibits actin-binding. Phosphorylation is required for the reorganization of the actin cytoskeleton in response to NGF. {ECO:0000250|UniProtKB:Q16658}.
uniprot
proteins
protein_family
Fascin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19343716
uniprot
proteins
pubmed
22155786
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8769857
uniprot
proteins
sequence_length
493
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:19343716}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q16658}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q16658}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:Q16658}. Cell projection, growth cone {ECO:0000269|PubMed:8769857}. Cell projection, filopodium {ECO:0000269|PubMed:8769857}. Cell projection, invadopodium {ECO:0000250|UniProtKB:Q61553}. Cell projection, microvillus {ECO:0000250|UniProtKB:Q16658}. Cell junction {ECO:0000250|UniProtKB:Q16658}. Note=Colocalized with RUFY3 and F-actin at filipodia of the axonal growth cone. Colocalized with DBN1 and F-actin at the transitional domain of the axonal growth cone. {ECO:0000250|UniProtKB:Q16658, ECO:0000250|UniProtKB:Q61553}.
uniprot
proteins