Grem2
entrez
23893
canonical
uniprot
O88273
canonical
ensembl
ENSMUSG00000050069
resolver
ensp
ENSMUSP00000049640
resolver
ensp
ENSMUSP00000262982
resolver
ensp
ENSMUSP00000262983
resolver
ensp
ENSMUSP00000262984
resolver
ensp
ENSMUSP00000262986
resolver
enst
ENSMUST00000055294
resolver
genesymbol
Grem2
resolver
genesymbol_syn
Cktsf1b2
resolver
genesymbol_syn
Prdc
resolver
uniprot
Q3TST1
resolver
uniprot_entry
GREM2_MOUSE
resolver
uniprot_entry
Q3TST1_MOUSE
resolver
amino_acid_sequence
MFWKLSLTLLLVAVLVKVAETRKNRPAGAIPSPYKDGSSNNSERWHHQIKEVLASSQEALVVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCYGQCNSFYIPRHVKKEEDSFQSCAFCKPQRVTSVIVELECPGLDPPFRIKKIQKVKHCRCMSVNLSDSDKQ
uniprot
proteins
function
FUNCTION: Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells. {ECO:0000269|PubMed:15039429, ECO:0000269|PubMed:23063586, ECO:0000269|PubMed:23850456}.
uniprot
proteins
mass_dalton
19334
uniprot
proteins
mutagenesis
MUTAGEN 68; /note="L->A: Slightly reduces affinity for BMP2 and BMP4. No effect on inhibition of BMP2 signaling."; /evidence="ECO:0000269|PubMed:23850456"; MUTAGEN 72; /note="W->A: Strongly reduces affinity for BMP2 and BMP4. Reduces inhibition of BMP2 signaling."; /evidence="ECO:0000269|PubMed:23850456"; MUTAGEN 96; /note="F->A: Reduces affinity for BMP2 and BMP4. Reduces inhibition of BMP2 signaling."; /evidence="ECO:0000269|PubMed:23850456"; MUTAGEN 98; /note="Y->A: Strongly reduces affinity for BMP2 and BMP4. Strongly reduces inhibition of BMP2 signaling."; /evidence="ECO:0000269|PubMed:23850456"; MUTAGEN 104; /note="F->A: Reduces affinity for BMP2 and BMP4. Strongly reduces inhibition of BMP2 signaling."; /evidence="ECO:0000269|PubMed:23850456"; MUTAGEN 105; /note="Y->A: Strongly reduces affinity for BMP2 and BMP4. Strongly reduces inhibition of BMP2 signaling."; /evidence="ECO:0000269|PubMed:23850456"; MUTAGEN 117; /note="F->A: Strongly reduces affinity for BMP2 and BMP4. Strongly reduces inhibition of BMP2 signaling."; /evidence="ECO:0000269|PubMed:23850456"; MUTAGEN 120; /note="C->S: No effect on dimerization. No effect on inhibition of BMP signaling."; /evidence="ECO:0000269|PubMed:23063586
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:23063586}.
uniprot
proteins
protein_family
DAN family
uniprot
proteins
pubmed
15039429
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23063586
uniprot
proteins
pubmed
23850456
uniprot
proteins
pubmed
26416033
uniprot
proteins
pubmed
9639362
uniprot
proteins
sequence_length
168
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
uniprot
proteins