ISG20
entrez
3669
canonical
uniprot
Q96AZ6
canonical
ensembl
ENSG00000172183
resolver
ensp
ENSP00000306565
resolver
ensp
ENSP00000453666
resolver
ensp
ENSP00000560319
resolver
ensp
ENSP00000560320
resolver
ensp
ENSP00000560321
resolver
ensp
ENSP00000560322
resolver
ensp
ENSP00000619917
resolver
ensp
ENSP00000619918
resolver
enst
ENST00000559876
resolver
enst
ENST00000890262
resolver
enst
ENST00000890263
resolver
enst
ENST00000949858
resolver
enst
ENST00000949859
resolver
genesymbol
ISG20
resolver
genesymbol_syn
HEM45
resolver
hgnc
HGNC:6130
resolver
uniprot
H0YMM4
resolver
uniprot
O00441
resolver
uniprot
O00586
resolver
uniprot_entry
H0YMM4_HUMAN
resolver
uniprot_entry
ISG20_HUMAN
resolver
uniprot_sec
O00441
resolver
uniprot_sec
O00586
resolver
amino_acid_sequence
MAGSREVVAMDCEMVGLGPHRESGLARCSLVNVHGAVLYDKFIRPEGEITDYRTRVSGVTPQHMVGATPFAVARLEILQLLKGKLVVGHDLKHDFQALKEDMSGYTIYDTSTDRLLWREAKLDHCRRVSLRVLSERLLHKSIQNSLLGHSSVEDARATMELYQISQRIRARRGLPRLAVSD
uniprot
proteins
ec_number
3.1.13.1
uniprot
proteins
function
FUNCTION: Interferon-induced antiviral exoribonuclease that acts mainly on single-stranded RNA (PubMed:11401564, PubMed:12594219, PubMed:16033969). Exhibits antiviral activity against RNA viruses including hepatitis C virus (HCV), hepatitis A virus (HAV) and yellow fever virus (YFV) (PubMed:16514659, PubMed:21036379). Inhibition of several viruses such as chikungunya virus (CHIKV) does not involve the degradation of viral RNAs, but rather the inhibition of translation of viral proteins (By similarity). Exerts a translational control over a large panel of non-self RNA substrates while sparing endogenous transcripts. This activity correlates with the protein's ability to localize in cytoplasmic processing bodies (PubMed:31600344). May also act as master regulator of over hundred interferon stimulated genes leading to viral genome translation inhibition (By similarity). May play additional roles in the maturation of snRNAs and rRNAs, and in ribosome biogenesis (PubMed:16514659). {ECO:0000250|UniProtKB:Q9JL16, ECO:0000269|PubMed:11401564, ECO:0000269|PubMed:12594219, ECO:0000269|PubMed:16033969, ECO:0000269|PubMed:16514659, ECO:0000269|PubMed:21036379, ECO:0000269|PubMed:31600344}.
uniprot
proteins
mass_dalton
20363
uniprot
proteins
protein_family
Exonuclease superfamily
uniprot
proteins
pubmed
11401564
uniprot
proteins
pubmed
12594219
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15527770
uniprot
proteins
pubmed
16033969
uniprot
proteins
pubmed
16514659
uniprot
proteins
pubmed
17445960
uniprot
proteins
pubmed
21036379
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
31600344
uniprot
proteins
pubmed
9235947
uniprot
proteins
pubmed
9569007
uniprot
proteins
sequence_length
181
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16514659}. Nucleus, nucleolus {ECO:0000269|PubMed:16514659}. Cytoplasm {ECO:0000269|PubMed:31600344}. Nucleus, Cajal body {ECO:0000269|PubMed:16514659}. Cytoplasm, P-body {ECO:0000269|PubMed:31600344}.
uniprot
proteins