CTDSP1
entrez
58190
canonical
uniprot
Q9GZU7
canonical
ensembl
ENSG00000144579
resolver
ensp
ENSP00000273062
resolver
ensp
ENSP00000518515
resolver
ensp
ENSP00000665963
resolver
ensp
ENSP00000665966
resolver
ensp
ENSP00000665967
resolver
genesymbol
CTDSP1
resolver
genesymbol_syn
NIF3
resolver
genesymbol_syn
NLIIF
resolver
genesymbol_syn
SCP1
resolver
hgnc
HGNC:21614
resolver
uniprot
C9IYG0
resolver
uniprot
Q7Z5Q3
resolver
uniprot
Q7Z5Q4
resolver
uniprot_entry
CTDS1_HUMAN
resolver
uniprot_sec
C9IYG0
resolver
uniprot_sec
Q7Z5Q3
resolver
uniprot_sec
Q7Z5Q4
resolver
activity_regulation
ACTIVITY REGULATION: Stimulated by GTF2F1. Inhibited by beryllofluoride anions. {ECO:0000269|PubMed:12721286}.
uniprot
proteins
amino_acid_sequence
MDSSAVITQISKEEARGPLRGKGDQKSAASQKPRSRGILHSLFCCVCRDDGEALPAHSGAPLLVEENGAIPKQTPVQYLLPEAKAQDSDKICVVIDLDETLVHSSFKPVNNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGAFRARLFRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWFDNMSDTELHDLLPFFEQLSRVDDVYSVLRQPRPGS
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. {ECO:0000269|PubMed:12721286, ECO:0000269|PubMed:15681389}.
uniprot
proteins
mass_dalton
29203
uniprot
proteins
mutagenesis
MUTAGEN 96; /note="D->E: No effect. Completely abolishes phosphatase activity; when associated with N-98."; /evidence="ECO:0000269|PubMed:12721286"; MUTAGEN 98; /note="D->N: Completely abolishes phosphatase activity; when associated with E-96."; /evidence="ECO:0000269|PubMed:12721286
uniprot
proteins
pubmed
10967134
uniprot
proteins
pubmed
12721286
uniprot
proteins
pubmed
15304220
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15681389
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17157258
uniprot
proteins
pubmed
22814378
uniprot
proteins
sequence_length
261
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12721286}. Note=Colocalizes with RNA polymerase II.
uniprot
proteins