PRRG4
entrez
79056
canonical
uniprot
Q9BZD6
canonical
ensembl
ENSG00000135378
resolver
ensp
ENSP00000257836
resolver
ensp
ENSP00000537913
resolver
ensp
ENSP00000537914
resolver
ensp
ENSP00000636944
resolver
ensp
ENSP00000636945
resolver
ensp
ENSP00000790314
resolver
enst
ENST00000257836
resolver
enst
ENST00000867854
resolver
enst
ENST00000867855
resolver
enst
ENST00000966885
resolver
enst
ENST00000966886
resolver
genesymbol
PRRG4
resolver
genesymbol_syn
PRGP4
resolver
genesymbol_syn
TMG4
resolver
hgnc
HGNC:30799
resolver
uniprot
A0A0S2Z5M6
resolver
uniprot
A0A0S2Z5N9
resolver
uniprot_entry
A0A0S2Z5M6_HUMAN
resolver
uniprot_entry
A0A0S2Z5N9_HUMAN
resolver
uniprot_entry
TMG4_HUMAN
resolver
amino_acid_sequence
MFTLLVLLSQLPTVTLGFPHCARGPKASKHAGEEVFTSKEEANFFIHRRLLYNRFDLELFTPGNLERECNEELCNYEEAREIFVDEDKTIAFWQEYSAKGPTTKSDGNREKIDVMGLLTGLIAAGVFLVIFGLLGYYLCITKCNRLQHPCSSAVYERGRHTPSIIFRRPEEAALSPLPPSVEDAGLPSYEQAVALTRKHSVSPPPPYPGHTKGFRVFKKSMSLPSH
uniprot
proteins
function
FUNCTION: May control axon guidance across the CNS (PubMed:28859078). Prevents the delivery of ROBO1 at the cell surface and down-regulates its expression (PubMed:28859078). {ECO:0000269|PubMed:28859078}.
uniprot
proteins
mass_dalton
25403
uniprot
proteins
mutagenesis
MUTAGEN 189; /note="Y->A: Reduced binding to MAGI1, MAGI3, NEDD4, NEDD4L, WWTR1 and YAP1."; /evidence="ECO:0000269|PubMed:23873930"; MUTAGEN 207; /note="Y->A: Reduced binding to MAGI1. No effect on binding to MAGI3, NEDD4, NEDD4L, WWTR1 or YAP1."; /evidence="ECO:0000269|PubMed:23873930
uniprot
proteins
post_translational_modification
PTM: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium. {ECO:0000255|PROSITE-ProRule:PRU00463, ECO:0000269|PubMed:23873930}.
uniprot
proteins
protein_family
Commissureless family
uniprot
proteins
pubmed
11171957
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23873930
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28859078
uniprot
proteins
pubmed
29059187
uniprot
proteins
sequence_length
226
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:28859078}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:23873930}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 114..134; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins