FCER2
entrez
2208
canonical
uniprot
P06734
canonical
ensembl
ENSG00000104921
resolver
ensp
ENSP00000264072
resolver
ensp
ENSP00000353178
resolver
ensp
ENSP00000471974
resolver
enst
ENST00000346664
resolver
enst
ENST00000360067
resolver
enst
ENST00000597921
resolver
genesymbol
FCER2
resolver
genesymbol_syn
CD23A
resolver
genesymbol_syn
CLEC4J
resolver
genesymbol_syn
FCE2
resolver
genesymbol_syn
IGEBF
resolver
hgnc
HGNC:3612
resolver
uniprot
K3W4U1
resolver
uniprot_entry
FCER2_HUMAN
resolver
uniprot_entry
K3W4U1_HUMAN
resolver
amino_acid_sequence
MEEGQYSEIEELPRRRCCRRGTQIVLLGLVTAALWAGLLTLLLLWHWDTTQSLKQLEERAARNVSQVSKNLESHHGDQMAQKSQSTQISQELEELRAEQQRLKSQDLELSWNLNGLQADLSSFKSQELNERNEASDLLERLREEVTKLRMELQVSSGFVCNTCPEKWINFQRKCYYFGKGTKQWVHARYACDDMEGQLVSIHSPEEQDFLTKHASHTGSWIGLRNLDLKGEFIWVDGSHVDYSNWAPGEPTSRSQGEDCVMMRGSGRWNDAFCDRKLGAWVCDRLATCTPPASEGSAESMGPDSRPDPDGRLPTPSAPLHS
uniprot
proteins
function
FUNCTION: Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B cells. On B cells, initiates IgE-dependent antigen uptake and presentation to T cells (PubMed:2167225). On macrophages, upon IgE binding and antigen cross-linking induces intracellular killing of parasites through activation of L-Arginine-nitric oxide pathway (PubMed:7544003). {ECO:0000269|PubMed:2167225, ECO:0000269|PubMed:7544003}.
uniprot
proteins
mass_dalton
36469
uniprot
proteins
post_translational_modification
PTM: N- and O-glycosylated.; PTM: The secreted form sCD23 is produced by ADAM10-mediated ectodomain shedding.
uniprot
proteins
pubmed
1386409
uniprot
proteins
pubmed
1417742
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16172256
uniprot
proteins
pubmed
16765898
uniprot
proteins
pubmed
17389606
uniprot
proteins
pubmed
2167225
uniprot
proteins
pubmed
22615937
uniprot
proteins
pubmed
23424103
uniprot
proteins
pubmed
2877743
uniprot
proteins
pubmed
2949326
uniprot
proteins
pubmed
2972386
uniprot
proteins
pubmed
3034567
uniprot
proteins
pubmed
37453717
uniprot
proteins
pubmed
7544003
uniprot
proteins
pubmed
8142907
uniprot
proteins
pubmed
8745401
uniprot
proteins
sequence_length
321
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor. Secreted {ECO:0000269|PubMed:37453717}. Note=Also exists as a soluble excreted form, sCD23.
uniprot
proteins
transmembrane_region
TRANSMEM 22..47; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins