IFI6
entrez
2537
canonical
uniprot
P09912
canonical
ensembl
ENSG00000126709
resolver
ensp
ENSP00000342513
resolver
ensp
ENSP00000354736
resolver
ensp
ENSP00000355152
resolver
genesymbol
IFI6
resolver
genesymbol_syn
G1P3
resolver
hgnc
HGNC:4054
resolver
uniprot
A0A348GSI1
resolver
uniprot
Q13141
resolver
uniprot
Q13142
resolver
uniprot
Q5VVR2
resolver
uniprot
Q5VVR3
resolver
uniprot
Q6IE95
resolver
uniprot
Q969M8
resolver
uniprot_entry
A0A348GSI1_HUMAN
resolver
uniprot_entry
IFI6_HUMAN
resolver
uniprot_sec
Q13141
resolver
uniprot_sec
Q13142
resolver
uniprot_sec
Q5VVR2
resolver
uniprot_sec
Q5VVR3
resolver
uniprot_sec
Q6IE95
resolver
uniprot_sec
Q969M8
resolver
amino_acid_sequence
MRQKAVSLFLCYLLLFTCSGVEAGKKKCSESSDSGSGFWKALTFMAVGGGLAVAGLPALGFTGAGIAANSVAASLMSWSAILNGGGVPAGGLVATLQSLGAGGSSVVIGNIGALMGYATHKYLDSEEDEE
uniprot
proteins
function
FUNCTION: Interferon-stimulated protein that plays an important role in innate immune response against a wide variety of viruses (PubMed:31142663). Inhibits flavivirus replication by preventing the formation of virus-induced endoplasmic reticulum membrane invaginations, which are double-membrane vesicles that flaviviruses use for their replication (PubMed:30224801). Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, whose activation is required for entry of the virus into cells (PubMed:25757571). Within the nucleus, restricts hepatitis B virus/HBV promoter activity leading to substantial reduction of viral replication and gene expression (PubMed:33868257). Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis (PubMed:15685448, PubMed:17823654, PubMed:26244642). However, it has also been shown to have a pro-apoptotic activity (PubMed:27673746). Modulates innate immune response mediated by RIGI by preventing its activation (PubMed:36793726). {ECO:0000269|PubMed:15685448, ECO:0000269|PubMed:17823654, ECO:0000269|PubMed:25757571, ECO:0000269|PubMed:26244642, ECO:0000269|PubMed:27673746, ECO:0000269|PubMed:30224801, ECO:0000269|PubMed:31142663, ECO:0000269|PubMed:33868257, ECO:0000269|PubMed:36793726}.
uniprot
proteins
mass_dalton
12927
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:15685448}.
uniprot
proteins
protein_family
IFI6/IFI27 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14728724
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15685448
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17823654
uniprot
proteins
pubmed
25757571
uniprot
proteins
pubmed
26244642
uniprot
proteins
pubmed
27673746
uniprot
proteins
pubmed
29899394
uniprot
proteins
pubmed
3017706
uniprot
proteins
pubmed
30224801
uniprot
proteins
pubmed
31142663
uniprot
proteins
pubmed
33868257
uniprot
proteins
pubmed
36793726
uniprot
proteins
pubmed
7596809
uniprot
proteins
sequence_length
130
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:30224801, ECO:0000269|PubMed:31142663}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion inner membrane {ECO:0000269|PubMed:15685448, ECO:0000269|PubMed:17823654, ECO:0000269|PubMed:25757571, ECO:0000269|PubMed:27673746, ECO:0000269|PubMed:29899394}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 41..61; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 75..95; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 99..119; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins