Clns1a
entrez
65160
canonical
uniprot
Q04753
canonical
ensembl
ENSRNOG00000012788
resolver
ensp
ENSRNOP00000017702
resolver
enst
ENSRNOT00000017702
resolver
genesymbol
Clns1a
resolver
genesymbol_syn
Icln
resolver
genesymbol_syn
Rcl1
resolver
uniprot
F7FFE2
resolver
uniprot
Q6P9X1
resolver
uniprot_entry
F7FFE2_RAT
resolver
uniprot_entry
ICLN_RAT
resolver
uniprot_entry
Q6P9X1_RAT
resolver
amino_acid_sequence
MSFLKSFPPPGSADGLRLQQPDTEAVLNGKGLGTGTLYIAESRLSWLDGSGLGFSLEYPTISLHAVSRDPNAYPQEHLYVMVNARFGEESKEPFSDEDEDDNDDVEPISEFRFVPSDKSALEAMFTAMCECQALHPDPEDEDSDDYDGEEYDVEAHEQGQGDIPTFYTYEEGLSHLTAEGQATLERLEGMLSQSVSSQYNMAGVRTEDSVRTYEDGMEVETTPTVAGQFEDADVDH
uniprot
proteins
function
FUNCTION: Involved in both the assembly of spliceosomal snRNPs and the methylation of Sm proteins (By similarity). Chaperone that regulates the assembly of spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs (By similarity). Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core) (By similarity). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP (By similarity). Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus (By similarity). {ECO:0000250|UniProtKB:P54105}.
uniprot
proteins
mass_dalton
26092
uniprot
proteins
protein_family
PICln (TC 1.A.47) family
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7683461
uniprot
proteins
pubmed
8313467
uniprot
proteins
pubmed
8391324
uniprot
proteins
sequence_length
236
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P54105}. Nucleus {ECO:0000250|UniProtKB:P54105}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P54105}. Note=A small fraction is also associated with the cytoskeleton. {ECO:0000250|UniProtKB:P54105}.
uniprot
proteins