Selenot
entrez
69227
canonical
uniprot
P62342
canonical
ensembl
ENSMUSG00000075700
resolver
ensp
ENSMUSP00000103557
resolver
genesymbol
Selenot
resolver
genesymbol_syn
Selt
resolver
uniprot
A2RTC6
resolver
uniprot
O95904
resolver
uniprot
Q8CHV4
resolver
uniprot
Q9CZ45
resolver
uniprot
Q9NZJ3
resolver
uniprot_entry
SELT_MOUSE
resolver
uniprot_sec
A2RTC6
resolver
uniprot_sec
O95904
resolver
uniprot_sec
Q8CHV4
resolver
uniprot_sec
Q9CZ45
resolver
uniprot_sec
Q9NZJ3
resolver
amino_acid_sequence
MRLLLLLLVAASAVVRSEASANLGGVPSKRLKMQYATGPLLKFQICVSUGYRRVFEEYMRVISQRYPDIRIEGENYLPQPIYRHIASFLSVFKLVLIGLIIVGKDPFAFFGMQAPSIWQWGQENKVYACMMVFFLSNMIENQCMSTGAFEITLNDVPVWSKLESGHLPSMQQLVQILDNEMKLNVHMDSIPHHRS
uniprot
proteins
ec_number
1.8.1.9
uniprot
proteins
function
FUNCTION: Selenoprotein with thioredoxin reductase-like oxidoreductase activity (By similarity). Protects dopaminergic neurons against oxidative stress and cell death (PubMed:26866473). Involved in ADCYAP1/PACAP-induced calcium mobilization and neuroendocrine secretion (By similarity). Plays a role in fibroblast anchorage and redox regulation (PubMed:19935881). In gastric smooth muscle, modulates the contraction processes through the regulation of calcium release and MYLK activation (By similarity). In pancreatic islets, involved in the control of glucose homeostasis, contributes to prolonged ADCYAP1/PACAP-induced insulin secretion (PubMed:23913443). {ECO:0000250|UniProtKB:Q1H5H1, ECO:0000269|PubMed:19935881, ECO:0000269|PubMed:23913443, ECO:0000269|PubMed:26866473}.
uniprot
proteins
mass_dalton
22292
uniprot
proteins
post_translational_modification
PTM: May contain a selenide-sulfide bond between Cys-46 and Sec-49. This bond is speculated to serve as redox-active pair (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
SelWTH family
uniprot
proteins
protein_family
Selenoprotein T subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19935881
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23913443
uniprot
proteins
pubmed
26866473
uniprot
proteins
sequence_length
195
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:23913443}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 85..103; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins