METTL4
entrez
64863
canonical
uniprot
Q8N3J2
canonical
ensembl
ENSG00000101574
resolver
ensp
ENSP00000320349
resolver
ensp
ENSP00000458290
resolver
ensp
ENSP00000648033
resolver
ensp
ENSP00000697484
resolver
ensp
ENSP00000785496
resolver
enst
ENST00000319888
resolver
enst
ENST00000574538
resolver
genesymbol
METTL4
resolver
hgnc
HGNC:24726
resolver
uniprot
B2RNA1
resolver
uniprot
J3KNJ7
resolver
uniprot
Q2TAA7
resolver
uniprot
Q9H5U9
resolver
uniprot_entry
J3KNJ7_HUMAN
resolver
uniprot_entry
METL4_HUMAN
resolver
uniprot_sec
B2RNA1
resolver
uniprot_sec
Q2TAA7
resolver
uniprot_sec
Q9H5U9
resolver
amino_acid_sequence
MSVVHQLSAGWLLDHLSFINKINYQLHQHHEPCCRKKEFTTSVHFESLQMDSVSSSGVCAAFIASDSSTKPENDDGGNYEMFTRKFVFRPELFDVTKPYITPAVHKECQQSNEKEDLMNGVKKEISISIIGKKRKRCVVFNQGELDAMEYHTKIRELILDGSLQLIQEGLKSGFLYPLFEKQDKGSKPITLPLDACSLSELCEMAKHLPSLNEMEHQTLQLVEEDTSVTEQDLFLRVVENNSSFTKVITLMGQKYLLPPKSSFLLSDISCMQPLLNYRKTFDVIVIDPPWQNKSVKRSNRYSYLSPLQIQQIPIPKLAAPNCLLVTWVTNRQKHLRFIKEELYPSWSVEVVAEWHWVKITNSGEFVFPLDSPHKKPYEGLILGRVQEKTALPLRNADVNVLPIPDHKLIVSVPCTLHSHKPPLAEVLKDYIKPDGEYLELFARNLQPGWTSWGNEVLKFQHVDYFIAVESGS
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
ec_number
2.1.1.72
uniprot
proteins
function
FUNCTION: N(6)-adenine-specific methyltransferase that can methylate both RNAs and DNA (PubMed:31913360, PubMed:32183942). Acts as a N(6)-adenine-specific RNA methyltransferase by catalyzing formation of N6,2'-O-dimethyladenosine (m6A(m)) on internal positions of U2 small nuclear RNA (snRNA): methylates the 6th position of adenine residues with a pre-deposited 2'-O-methylation (PubMed:31913360). Internal m6A(m) methylation of snRNAs regulates RNA splicing (PubMed:31913360). Also able to act as a N(6)-adenine-specific DNA methyltransferase by mediating methylation of DNA on the 6th position of adenine (N(6)-methyladenosine) (PubMed:32183942). The existence of N(6)-methyladenosine (m6A) on DNA is however unclear in mammals, and additional evidence is required to confirm the role of the N(6)-adenine-specific DNA methyltransferase activity of METTL4 in vivo (PubMed:32203414). Acts as a regulator of mitochondrial transcript levels and mitochondrial DNA (mtDNA) copy number by mediating mtDNA N(6)-methylation: m6A on mtDNA reduces transcription by repressing TFAM DNA-binding and bending (PubMed:32183942). N(6)-methyladenosine deposition by METTL4 regulates Polycomb silencing by triggering ubiquitination and degradation of sensor proteins ASXL1 and MPND, leading to inactivation of the PR-DUB complex and subsequent preservation of Polycomb silencing (By similarity). {ECO:0000250|UniProtKB:Q3U034, ECO:0000269|PubMed:31913360, ECO:0000269|PubMed:32183942, ECO:0000269|PubMed:32203414}.
uniprot
proteins
mass_dalton
54041
uniprot
proteins
mutagenesis
MUTAGEN 287..290; /note="DPPW->APPA: Abolished methyltransferase activity."; /evidence="ECO:0000269|PubMed:31913360, ECO:0000269|PubMed:32183942
uniprot
proteins
protein_family
MT-A70-like family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21248752
uniprot
proteins
pubmed
31913360
uniprot
proteins
pubmed
32183942
uniprot
proteins
pubmed
32203414
uniprot
proteins
sequence_length
472
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31913360, ECO:0000269|PubMed:32183942}. Cytoplasm, cytosol {ECO:0000269|PubMed:32183942}. Mitochondrion matrix {ECO:0000269|PubMed:32183942}.
uniprot
proteins