Sult2b1
entrez
292915
canonical
uniprot
Q29YR5
canonical
ensembl
ENSRNOG00000021046
resolver
ensembl
ENSRNOG00055006674
resolver
ensembl
ENSRNOG00060010544
resolver
ensembl
ENSRNOG00065031391
resolver
ensp
ENSRNOP00000028570
resolver
ensp
ENSRNOP00000060264
resolver
ensp
ENSRNOP00000089238
resolver
genesymbol
Sult2b1
resolver
uniprot
Q29YR6
resolver
uniprot_entry
ST2B1_RAT
resolver
uniprot_sec
Q29YR6
resolver
amino_acid_sequence
MDGPQPPALWGSLENRVSELSQKLQGEYFRYKGIPFPVGMYTPESLSLAENTSNVRDDDIFIVTYPKSGTNWMIEIICLILKDGDPSWIRSEPIWQRAPWCETTISAFSLPERPSPRLMCSHLPIELFTKAAFSSKAKVIYLGRNPRDVVVSLYYYSKIAVQLKDPGTPEQFLQNFLKGEVQFGSWFDHIKGWIRMRGRENFLFITYEELQQDLRGSVQLICEFLGRPLGEEALSSVVAHSAFAAMKANNMSNYTLLPASLLDHRQGAFLRKGISGDWKNHFTVAQSETFDQVYREQMHGLPSFPWDRSAEDGSPDGETEPSPSPSPGLASDDPNPGSSQ
uniprot
proteins
ec_number
2.8.2.2
uniprot
proteins
function
FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfonates cholesterol (PubMed:16368200). Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA) (PubMed:16368200). Conjugates efficiently cholesterol but has a greater affinity for pregnenolone sulfation. Does not show high activity with DHEA (PubMed:16368200). Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (By similarity). {ECO:0000250|UniProtKB:O00204, ECO:0000269|PubMed:16368200}.; FUNCTION: [Isoform 2]: Prefers pregnenolone over DHEA as a substrate and does not sulfate cholesterol. {ECO:0000269|PubMed:16368200}.
uniprot
proteins
mass_dalton
38322
uniprot
proteins
protein_family
Sulfotransferase 1 family
uniprot
proteins
pubmed
16368200
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
340
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P52843}. Microsome {ECO:0000250|UniProtKB:O00204}. Nucleus {ECO:0000250|UniProtKB:O00204}.
uniprot
proteins