CDK19
entrez
23097
canonical
uniprot
Q9BWU1
canonical
ensembl
ENSG00000155111
resolver
ensp
ENSP00000317665
resolver
ensp
ENSP00000357907
resolver
ensp
ENSP00000410604
resolver
ensp
ENSP00000598053
resolver
enst
ENST00000413605
resolver
genesymbol
CDK19
resolver
genesymbol_syn
CDC2L6
resolver
genesymbol_syn
CDK11
resolver
genesymbol_syn
KIAA1028
resolver
hgnc
HGNC:19338
resolver
uniprot
B4DUB1
resolver
uniprot
F6QTA4
resolver
uniprot
I6W807
resolver
uniprot
Q5JQZ7
resolver
uniprot
Q5JR00
resolver
uniprot
Q8TC78
resolver
uniprot
Q9UPX2
resolver
uniprot_entry
B4DUB1_HUMAN
resolver
uniprot_entry
CDK19_HUMAN
resolver
uniprot_entry
F6QTA4_HUMAN
resolver
uniprot_entry
I6W807_HUMAN
resolver
uniprot_sec
Q5JQZ7
resolver
uniprot_sec
Q5JR00
resolver
uniprot_sec
Q8TC78
resolver
uniprot_sec
Q9UPX2
resolver
amino_acid_sequence
MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDDPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGVGGTGAGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSSQYHPSHQAHRY
uniprot
proteins
disease_involvement
DISEASE: Developmental and epileptic encephalopathy 87 (DEE87) [MIM:618916]: A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE87 inheritance is autosomal dominant. {ECO:0000269|PubMed:32330417, ECO:0000269|PubMed:33134521, ECO:0000269|PubMed:33495529}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.11.22
uniprot
proteins
function
FUNCTION: Component of the Mediator complex, a transcriptional coactivator required for regulated expression of nearly all RNA polymerase II-dependent genes. Acts as a molecular bridge between gene-specific regulatory proteins and the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters through direct interactions with transcriptional regulators and serves as a scaffold for assembly of the pre-initiation complex with RNA polymerase II and general transcription factors. Contributes to phosphorylation of transcription factors and other substrates, including RNA polymerase II and the Notch1 intracellular domain (ICN1), thereby modulating gene expression programs (PubMed:25344755, PubMed:28855340, PubMed:29440396). Plays a role together with CDK8 in normal macrophage differentiation (By similarity). {ECO:0000250|UniProtKB:Q8BWD8, ECO:0000269|PubMed:25344755, ECO:0000269|PubMed:28855340, ECO:0000269|PubMed:29440396}.
uniprot
proteins
mass_dalton
56802
uniprot
proteins
protein_family
CDC2/CDKX subfamily
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10470851
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
25344755
uniprot
proteins
pubmed
28855340
uniprot
proteins
pubmed
29440396
uniprot
proteins
pubmed
32330417
uniprot
proteins
pubmed
33134521
uniprot
proteins
pubmed
33495529
uniprot
proteins
sequence_length
502
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:32330417}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:32330417}. Nucleus {ECO:0000269|PubMed:32330417}.
uniprot
proteins