Stimate
entrez
69179
canonical
uniprot
Q3UF25
canonical
ensembl
ENSMUSG00000006526
resolver
ensp
ENSMUSP00000006701
resolver
enst
ENSMUST00000006701
resolver
genesymbol
Stimate
resolver
genesymbol_syn
Tmem110
resolver
uniprot
Q3U2J0
resolver
uniprot
Q8C691
resolver
uniprot
Q8R3U0
resolver
uniprot
Q9D7D4
resolver
uniprot
Q9D8S1
resolver
uniprot_entry
STIMA_MOUSE
resolver
uniprot_sec
Q3U2J0
resolver
uniprot_sec
Q8C691
resolver
uniprot_sec
Q8R3U0
resolver
uniprot_sec
Q9D7D4
resolver
uniprot_sec
Q9D8S1
resolver
amino_acid_sequence
MQGPGGNVSRGLPSGPASTVASGAGRCESGALMHSFGIFLQGLLGVVAFSTLMLKRFREPKHERRPWRIWFLDTSKQAIGMLFIHFANVYLADLTEEDPCSLYLINFLLDATVGMLLIYVGVRAVGVLVEWQQWESLRFGEYGDPLQCGAWVGQCALYIVIMIFEKSVVFIVLLILQWKKVALLNPIENPDLKLAIVMLIVPFFVNAFMFWVVDNFLMRKGKTKAKLEERGANQDSRNGSKVRYRRAASHEESESEILISADDEMEESDAEEDLRRPVKKKHRFGLPV
uniprot
proteins
function
FUNCTION: Acts as a regulator of store-operated Ca(2+) entry (SOCE) at junctional sites that connect the endoplasmic reticulum (ER) and plasma membrane (PM), called ER-plasma membrane (ER-PM) junction or cortical ER. SOCE is a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts by interacting with STIM1, promoting STIM1 conformational switch. Involved in STIM1 relocalization to ER-PM junctions. Contributes to the maintenance and reorganization of store-dependent ER-PM junctions. {ECO:0000250|UniProtKB:Q86TL2}.
uniprot
proteins
mass_dalton
32500
uniprot
proteins
protein_family
STIMATE family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
26322679
uniprot
proteins
sequence_length
288
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q86TL2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q86TL2}. Note=Colocalizes with STIM1 at ER-plasma membrane (ER-PM) junctions, also called cortical endoplasmic reticulum (ER), in store-depleted calcium cells. May translocate to ER-PM junctions in a STIM1-dependent manner in store-depleted cells. {ECO:0000250|UniProtKB:Q86TL2}.
uniprot
proteins
transmembrane_region
TRANSMEM 29..49; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 69..89; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 102..122; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 156..176; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 194..214; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins