Fxyd7
entrez
63848
canonical
uniprot
P59649
canonical
ensembl
ENSRNOG00000021067
resolver
ensp
ENSRNOP00000028603
resolver
enst
ENSRNOT00000028603
resolver
genesymbol
Fxyd7
resolver
uniprot_entry
FXYD7_RAT
resolver
amino_acid_sequence
MATPTQSPTNVPEETDPFFYDYATVQTVGMTLATIMFVLGIIIIISKKVKCRKADSRSESPTCKSCKSELPSSAPGGGGV
uniprot
proteins
function
FUNCTION: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (By similarity). Reduces the apparent affinity for external K(+), an effect that depends on the presence of external Na(+) and voltage (By similarity). Increases the apparent affinity for intracellular Na(+) (By similarity). {ECO:0000250|UniProtKB:P58549, ECO:0000250|UniProtKB:P59648}.
uniprot
proteins
mass_dalton
8487
uniprot
proteins
mutagenesis
MUTAGEN 3; /note="T->A: Inhibits cell surface expression. Inhibits cell surface expression; when associated with A-5. Inhibits cell surface expression; when associated with A-5 and A-9."; /evidence="ECO:0000269|PubMed:22535957"; MUTAGEN 5; /note="T->A: Inhibits cell surface expression. Inhibits cell surface expression; when associated with A-3. Inhibits cell surface expression; when associated with A-3 and A-9."; /evidence="ECO:0000269|PubMed:22535957"; MUTAGEN 9; /note="T->A: Does not inhibit cell surface expression. Inhibits cell surface expression; when associated with A-3 and A-9."; /evidence="ECO:0000269|PubMed:22535957
uniprot
proteins
post_translational_modification
PTM: O-glycosylated; required for stabilization and translocation to the plasma membrane. {ECO:0000269|PubMed:22535957}.
uniprot
proteins
protein_family
FXYD family
uniprot
proteins
pubmed
10950925
uniprot
proteins
pubmed
12093728
uniprot
proteins
pubmed
22535957
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
80
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22535957}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P59648}. Note=Able to translocate to the plasma membrane of Xenopus oocytes independent of its association with NKA (PubMed:22535957). Lacks a cleavable signal sequence (By similarity). {ECO:0000250|UniProtKB:P59648, ECO:0000269|PubMed:22535957}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..45; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins