S100a4
entrez
24615
canonical
uniprot
P05942
canonical
ensembl
ENSRNOG00000011821
resolver
ensembl
ENSRNOG00055022546
resolver
ensembl
ENSRNOG00060032473
resolver
ensembl
ENSRNOG00065027428
resolver
ensp
ENSRNOP00000015958
resolver
ensp
ENSRNOP00055031425
resolver
ensp
ENSRNOP00060046452
resolver
ensp
ENSRNOP00065038767
resolver
enst
ENSRNOT00000015958
resolver
enst
ENSRNOT00055038702
resolver
enst
ENSRNOT00060056246
resolver
enst
ENSRNOT00065047279
resolver
genesymbol
S100a4
resolver
uniprot_entry
S10A4_RAT
resolver
amino_acid_sequence
MARPLEEALDVIVSTFHKYSGNEGDKFKLNKTELKELLTRELPSFLGRRTDEAAFQKLMNNLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGCPDKEPRKK
uniprot
proteins
function
FUNCTION: Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy. Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (By similarity). Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (By similarity). Also modulates the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (By similarity). Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes (By similarity). In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (By similarity). {ECO:0000250|UniProtKB:P07091, ECO:0000250|UniProtKB:P26447}.
uniprot
proteins
mass_dalton
11776
uniprot
proteins
protein_family
S-100 family
uniprot
proteins
pubmed
1741158
uniprot
proteins
pubmed
3422491
uniprot
proteins
pubmed
3430604
uniprot
proteins
sequence_length
101
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P26447}. Nucleus {ECO:0000250|UniProtKB:P26447}. Cytoplasm {ECO:0000250|UniProtKB:P07091}.
uniprot
proteins