IL5
entrez
3567
canonical
uniprot
P05113
canonical
ensembl
ENSG00000113525
resolver
ensp
ENSP00000231454
resolver
ensp
ENSP00000547628
resolver
genesymbol
IL5
resolver
hgnc
HGNC:6016
resolver
uniprot
Q13840
resolver
uniprot_entry
IL5_HUMAN
resolver
uniprot_sec
Q13840
resolver
amino_acid_sequence
MRMLLHLSLLALGAAYVYAIPTEIPTSALVKETLALLSTHRTLLIANETLRIPVPVHKNHQLCTEEIFQGIGTLESQTVQGGTVERLFKNLSLIKKYIDGQKKKCGEERRRVNQFLDYLQEFLGVMNTEWIIES
uniprot
proteins
function
FUNCTION: Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:2653458, PubMed:9010276). Also acts on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (By similarity). Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB (PubMed:1495999, PubMed:22528658). Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively (PubMed:7613138). {ECO:0000250|UniProtKB:P04401, ECO:0000269|PubMed:1495999, ECO:0000269|PubMed:22528658, ECO:0000269|PubMed:2653458, ECO:0000269|PubMed:7613138, ECO:0000269|PubMed:9010276}.
uniprot
proteins
mass_dalton
15238
uniprot
proteins
protein_family
IL-5 family
uniprot
proteins
pubmed
1495999
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2037074
uniprot
proteins
pubmed
22153509
uniprot
proteins
pubmed
22528658
uniprot
proteins
pubmed
2361960
uniprot
proteins
pubmed
2653458
uniprot
proteins
pubmed
2823259
uniprot
proteins
pubmed
2824500
uniprot
proteins
pubmed
3024129
uniprot
proteins
pubmed
32211550
uniprot
proteins
pubmed
3498940
uniprot
proteins
pubmed
7613138
uniprot
proteins
pubmed
8483502
uniprot
proteins
pubmed
9010276
uniprot
proteins
sequence_length
134
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2653458}.
uniprot
proteins