Mesp2
entrez
17293
canonical
uniprot
O08574
canonical
ensembl
ENSMUSG00000030543
resolver
ensp
ENSMUSP00000103017
resolver
enst
ENSMUST00000107394
resolver
genesymbol
Mesp2
resolver
uniprot
A6H5V4
resolver
uniprot
F6W1V8
resolver
uniprot
Q3UIV5
resolver
uniprot_entry
A6H5V4_MOUSE
resolver
uniprot_entry
F6W1V8_MOUSE
resolver
uniprot_entry
MESP2_MOUSE
resolver
uniprot_sec
Q3UIV5
resolver
amino_acid_sequence
MAQSSPPQSLQGLVPLGLLPGLGLGSAIGLHVSGLVLRFVRFLPFYATRRPSQPAGPARSTRTTQATAPRRTRPAPAGGQRQSASEREKLRMRTLARALQELRRFLPPSVAPAGQSLTKIETLRLAIRYIGHLSALLGLSEDSLRRRRRRSADAAFSHRCPQCPDGGSPSQAQMLGPSLGSAMSSGVSWGCPPACPGPLISPENLGNRISNVDPRVTPPYCPQIQSPLHQSLERAADSSPWAPPQACPGMQMSPEPRNKTGHWTQSTEPAELTKVYQSLSVSPEPRLSLGSPLLLPRPSCQRLQPQPQPQPQWGCWGHDAEVLSTSEDQGSSPALQLPVASPTPSSGLQLSGCPELWQEDLEGPPLNIFY
uniprot
proteins
function
FUNCTION: Transcription factor with important role in somitogenesis. Defines the rostrocaudal patterning of the somite by participating in distinct Notch pathways. Also regulates the FGF signaling pathway. Specifies the rostral half of the somites. Generates rostro-caudal polarity of somites by down-regulating in the presumptive rostral domain DLL1, a Notch ligand. Participates in the segment border formation by activating in the anterior presomitic mesoderm LFNG, a negative regulator of DLL1-Notch signaling. Acts as a strong suppressor of Notch activity. Together with MESP1 is involved in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. May play a role with Tcf15 in the differentiation of myotomal and sclerotomal cells by regulating Pax family genes. Also controls the expression of the protocadherin PCDH8/PAPC, EPHA4, RIPPLY2, NOTCH2, FGFR1, and CER1. Binds to the E-boxes within the EPH4A and RIPPLY2 enhancers. {ECO:0000269|PubMed:10887078, ECO:0000269|PubMed:10932180, ECO:0000269|PubMed:12591245, ECO:0000269|PubMed:12900443, ECO:0000269|PubMed:15677726, ECO:0000269|PubMed:15902259, ECO:0000269|PubMed:16728472, ECO:0000269|PubMed:17306789, ECO:0000269|PubMed:17477400, ECO:0000269|PubMed:9242490}.
uniprot
proteins
mass_dalton
39789
uniprot
proteins
mutagenesis
MUTAGEN 70..73; /note="RRTR->AATA: Localizes in nucleus and cytoplasm. Localizes mainly in cytoplasm; when associated with 145-A--A-150."; /evidence="ECO:0000269|PubMed:16996494"; MUTAGEN 145..150; /note="RRRRRR->AAAAAA: Localizes in nucleus and cytoplasm. Localizes mainly in cytoplasm; when associated with 70-A--A-73."; /evidence="ECO:0000269|PubMed:16996494
uniprot
proteins
post_translational_modification
PTM: Degraded by the proteasome.; PTM: Phosphorylated. {ECO:0000269|PubMed:16996494}.
uniprot
proteins
pubmed
10330372
uniprot
proteins
pubmed
10887078
uniprot
proteins
pubmed
10932180
uniprot
proteins
pubmed
11562355
uniprot
proteins
pubmed
12591245
uniprot
proteins
pubmed
12900443
uniprot
proteins
pubmed
15677726
uniprot
proteins
pubmed
15902259
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16505380
uniprot
proteins
pubmed
16728472
uniprot
proteins
pubmed
16996494
uniprot
proteins
pubmed
17306789
uniprot
proteins
pubmed
17360776
uniprot
proteins
pubmed
17477400
uniprot
proteins
pubmed
9242490
uniprot
proteins
sequence_length
370
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:15902259, ECO:0000269|PubMed:16996494}.
uniprot
proteins