Tfrc
entrez
22042
canonical
uniprot
Q62351
canonical
ensembl
ENSMUSG00000022797
resolver
ensp
ENSMUSP00000023486
resolver
ensp
ENSMUSP00000258507
resolver
enst
ENSMUST00000023486
resolver
genesymbol
Tfrc
resolver
genesymbol_syn
Trfr
resolver
uniprot
Q542D9
resolver
uniprot
Q61560
resolver
uniprot_entry
Q542D9_MOUSE
resolver
uniprot_entry
TFR1_MOUSE
resolver
uniprot_sec
Q61560
resolver
amino_acid_sequence
MMDQARSAFSNLFGGEPLSYTRFSLARQVDGDNSHVEMKLAADEEENADNNMKASVRKPKRFNGRLCFAAIALVIFFLIGFMSGYLGYCKRVEQKEECVKLAETEETDKSETMETEDVPTSSRLYWADLKTLLSEKLNSIEFADTIKQLSQNTYTPREAGSQKDESLAYYIENQFHEFKFSKVWRDEHYVKIQVKSSIGQNMVTIVQSNGNLDPVESPEGYVAFSKPTEVSGKLVHANFGTKKDFEELSYSVNGSLVIVRAGEITFAEKVANAQSFNAIGVLIYMDKNKFPVVEADLALFGHAHLGTGDPYTPGFPSFNHTQFPPSQSSGLPNIPVQTISRAAAEKLFGKMEGSCPARWNIDSSCKLELSQNQNVKLIVKNVLKERRILNIFGVIKGYEEPDRYVVVGAQRDALGAGVAAKSSVGTGLLLKLAQVFSDMISKDGFRPSRSIIFASWTAGDFGAVGATEWLEGYLSSLHLKAFTYINLDKVVLGTSNFKVSASPLLYTLMGKIMQDVKHPVDGKSLYRDSNWISKVEKLSFDNAAYPFLAYSGIPAVSFCFCEDADYPYLGTRLDTYEALTQKVPQLNQMVRTAAEVAGQLIIKLTHDVELNLDYEMYNSKLLSFMKDLNQFKTDIRDMGLSLQWLYSARGDYFRATSRLTTDFHNAEKTNRFVMREINDRIMKVEYHFLSPYVSPRESPFRHIFWGSGSHTLSALVENLKLRQKNITAFNETLFRNQLALATWTIQGVANALSGDIWNIDNEF
uniprot
proteins
function
FUNCTION: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes (By similarity). Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Upon stimulation, positively regulates T and B cell proliferation through iron uptake (PubMed:26642240). Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway (By similarity). When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiquitination and subsequent degradation of the mitofusin MFN2 and inhibition of mitochondrial fusion (By similarity). When dietary levels of stearate (C18:0) are high, TFRC stearoylation inhibits activation of the JNK pathway and thus degradation of the mitofusin MFN2 (By similarity). Mediates uptake of NICOL1 into fibroblasts where it may regulate extracellular matrix production (PubMed:38625739). {ECO:0000250, ECO:0000269|PubMed:10192390, ECO:0000269|PubMed:26642240, ECO:0000269|PubMed:38625739}.
uniprot
proteins
mass_dalton
85731
uniprot
proteins
mutagenesis
MUTAGEN 20; /note="Y->H: Negatively regulates of T and B cell proliferation upon activation. Significantly increases cell surface expression on T and B cells. Impairs internalization."; /evidence="ECO:0000269|PubMed:26642240
uniprot
proteins
post_translational_modification
PTM: Stearoylated by ZDHHC6 which inhibits TFRC-mediated activation of the JNK pathway and promotes mitochondrial fragmentation (By similarity). Stearoylation does not affect iron uptake (By similarity). {ECO:0000250|UniProtKB:P02786}.; PTM: N- and O-glycosylated, phosphorylated and palmitoylated. {ECO:0000250}.; PTM: Ubiquitinated via 'Lys-27'-linked chains, leading to enhanced degradation. {ECO:0000250|UniProtKB:P02786}.
uniprot
proteins
protein_family
M28B subfamily
uniprot
proteins
protein_family
Peptidase M28 family
uniprot
proteins
pubmed
10192390
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26642240
uniprot
proteins
pubmed
2984291
uniprot
proteins
pubmed
38625739
uniprot
proteins
pubmed
6092468
uniprot
proteins
sequence_length
763
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P02786}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P02786}. Melanosome {ECO:0000250|UniProtKB:P02786}.
uniprot
proteins
transmembrane_region
TRANSMEM 68..88; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins