Asb2
entrez
65256
canonical
uniprot
Q8K0L0
canonical
ensembl
ENSMUSG00000021200
resolver
ensp
ENSMUSP00000021617
resolver
ensp
ENSMUSP00000117595
resolver
genesymbol
Asb2
resolver
uniprot
Q9CTH4
resolver
uniprot
Q9WV73
resolver
uniprot_entry
ASB2_MOUSE
resolver
uniprot_sec
Q9CTH4
resolver
uniprot_sec
Q9WV73
resolver
amino_acid_sequence
MATEISTRGRQRAIGHEEYSLYSSLSEEELLQMAIEQSLADKTRGPTPAEASASSQTNHQPGHFHPWTRSPSSPENPPARAPLGLFQGVMQKYSSNLFKTSQMAAMDPVLKAIKEGDEEALKIMIQDGKNLAEPNKEGWLPLHEAAYYGQLGCLKVLQQAYPGTIDQRTLQEETALYLATCREHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVRILVRYNADANHRCNRGWTALHESVSRNDLEVMEILVSGGAKVEAKNVYSITPLFVAAQSGQLEALRFLAKHGADINTQASDSASALYEASKNEHEDVVEFLLSQGADANKANKDGLLPLHVASKKGNYRIVQMLLPVTSRTRVRRSGISPLHLAAERNHDAVLEALLAARFDVNAPLAPERARLYEDRRSSALYFAVVNNNVYATELLLLAGADPNRDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPPAPRPGRFHDAPVDDKAPSVVQFCEFLSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENTQ
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Mediates Notch-induced ubiquitination and degradation of substrates including TCF3/E2A and JAK2 (By similarity). Required during embryonic heart development for complete heart looping (PubMed:32179481). Required for cardiomyocyte differentiation (By similarity). Specifically promotes the ubiquitination of SMAD9 and targets it for proteasomal degradation, leading to avoid excessive accumulation of SMAD9 (By similarity). Plays a role in the regulation of NK-cell migration by modulating protein levels of filamin A/FLNA via regulation of its ubiquitination and proteasome degradation (PubMed:33717133). {ECO:0000250|UniProtKB:Q96Q27, ECO:0000269|PubMed:32179481, ECO:0000269|PubMed:33717133}.; FUNCTION: [Isoform 1]: Involved in myogenic differentiation and targets filamin FLNB for proteasomal degradation but not filamin FLNA (PubMed:26343497). Also targets DES for proteasomal degradation (PubMed:26343497). Acts as a negative regulator of skeletal muscle mass (PubMed:27182554). {ECO:0000269|PubMed:26343497, ECO:0000269|PubMed:27182554}.; FUNCTION: [Isoform 2]: Targets filamins FLNA and FLNB for proteasomal degradation (PubMed:23632887). This leads to enhanced adhesion of hematopoietic cells to fibronectin (By similarity). Required for FLNA degradation in immature cardiomyocytes which is necessary for actin cytoskeleton remodeling, leading to proper organization of myofibrils and function of mature cardiomyocytes (PubMed:29374072). Required for degradation of FLNA and FLNB in immature dendritic cells (DC) which enhances immature DC migration by promoting DC podosome formation and DC-mediated degradation of the extracellular matrix (PubMed:23632887). Does not promote proteasomal degradation of tyrosine-protein kinases JAK1 or JAK2 in hematopoietic cells (By similarity). {ECO:0000250|UniProtKB:Q96Q27, ECO:0000269|PubMed:23632887, ECO:0000269|PubMed:29374072}.
uniprot
proteins
mass_dalton
70221
uniprot
proteins
mutagenesis
MUTAGEN 595; /note="L->A: Loss of E3 ubiquitin-protein ligase complex association and loss of activity of the complex. Does not affect localization of isoform 1 to the Z line or its interaction with DES."; /evidence="ECO:0000269|PubMed:19300455, ECO:0000269|PubMed:26343497
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: [Isoform 1]: Monoubiquitinated. {ECO:0000250|UniProtKB:Q96Q27}.; PTM: [Isoform 2]: Not monoubiquitinated. {ECO:0000250|UniProtKB:Q96Q27}.; PTM: [Isoform 2]: Phosphorylation at Ser-371 is required for association with FLNA and subsequent FLNA degradation. {ECO:0000250|UniProtKB:Q96Q27}.
uniprot
proteins
protein_family
Ankyrin SOCS box (ASB) family
uniprot
proteins
pubmed
11111040
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19300455
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23632887
uniprot
proteins
pubmed
26343497
uniprot
proteins
pubmed
27182554
uniprot
proteins
pubmed
29374072
uniprot
proteins
pubmed
31175139
uniprot
proteins
pubmed
32179481
uniprot
proteins
pubmed
33717133
uniprot
proteins
pubmed
33993984
uniprot
proteins
sequence_length
634
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:Q96Q27}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:26343497}. Note=Localizes to the Z line in cardiomyocytes. {ECO:0000269|PubMed:26343497}.
uniprot
proteins