Papss2
entrez
23972
canonical
uniprot
O88428
canonical
ensembl
ENSMUSG00000024899
resolver
ensp
ENSMUSP00000025833
resolver
ensp
ENSMUSP00000157455
resolver
ensp
ENSMUSP00000158330
resolver
ensp
ENSMUSP00000196884
resolver
enst
ENSMUST00000025833
resolver
enst
ENSMUST00000235594
resolver
enst
ENSMUST00000236290
resolver
genesymbol
Papss2
resolver
genesymbol_syn
Atpsk2
resolver
uniprot
A0A494B923
resolver
uniprot
A0A494BB18
resolver
uniprot
Q5BKP4
resolver
uniprot
Q9Z274
resolver
uniprot_entry
A0A494B923_MOUSE
resolver
uniprot_entry
A0A494BB18_MOUSE
resolver
uniprot_entry
PAPS2_MOUSE
resolver
uniprot_sec
Q5BKP4
resolver
uniprot_sec
Q9Z274
resolver
amino_acid_sequence
MSANFKMNHKRDQQKSTNVVYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTISFALEEYLVSHAIPCYSLDGDNVRHGLNKNLGFSAGDREENIRRIAEVARLFADAGLVCITSFISPFAKDRENARKIHESAGLPFFEIFVDAPLNICESRDVKGLYKRARAGEIKGFTGIDSDYEKPETPECVLKTNLSSVSDCVQQVVELLQEQNIVPHTTIKGIHELFVPENKVDQIRAEAETLPSLPITKLDLQWVQILSEGWATPLKGFMREKEYLQTLHFDTLLDGVVPRDGVINMSIPIVLPVSADDKARLEGCSKFALMYEGRRVALLQDPEFYEHRKEERCSRVWGTATAKHPHIKMVMESGDWLVGGDLQVLERIRWDDGLDQYRLTPLELKQKCKDMNADAVFAFQLRNPVHNGHALLMQDTRRRLLERGYKHPVLLLHPLGGWTKDDDVPLEWRMKQHAAVLEERVLDPKSTIVAIFPSPMLYAGPTEVQWHCRCRMIAGANFYIVGRDPAGMPHPETKKDLYEPTHGGKVLSMAPGLTSVEIIPFRVAAYNKIKKAMDFYDPARHEEFDFISGTRMRKLAREGEDPPDGFMAPKAWKVLTDYYRSLEKTN
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Papss2 are the cause of brachymorphism (bm), a autosomal recessive disease, which is characterized by abnormal hepatic detoxification, bleeding times and postnatal growth, such as dome-shaped skull, short thick tail, and shortened but not widened limbs. The abnormal postnatal growth has been attributed to undersulfation of cartilage proteoglycans.
uniprot
proteins
ec_number
2.7.1.25
uniprot
proteins
ec_number
2.7.7.4
uniprot
proteins
function
FUNCTION: Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate/PAPS, the activated sulfate donor used by sulfotransferases (PubMed:10559207). In mammals, PAPS is the sole source of sulfate while APS appears to only be an intermediate in the sulfate-activation pathway. May have an important role in skeletogenesis during postnatal growth. {ECO:0000269|PubMed:10559207}.
uniprot
proteins
mass_dalton
70351
uniprot
proteins
pathway_participation
PATHWAY: Sulfur metabolism; sulfate assimilation. {ECO:0000305|PubMed:10559207}.
uniprot
proteins
protein_family
APS kinase family; Sulfate adenylyltransferase family
uniprot
proteins
pubmed
10559207
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9671738
uniprot
proteins
pubmed
9771708
uniprot
proteins
sequence_length
621
uniprot
proteins