HIPK3
entrez
10114
canonical
uniprot
Q9H422
canonical
ensembl
ENSG00000110422
resolver
ensp
ENSP00000304226
resolver
ensp
ENSP00000368301
resolver
ensp
ENSP00000398241
resolver
ensp
ENSP00000431710
resolver
genesymbol
HIPK3
resolver
genesymbol_syn
DYRK6
resolver
genesymbol_syn
FIST3
resolver
genesymbol_syn
PKY
resolver
hgnc
HGNC:4915
resolver
uniprot
A8KAE4
resolver
uniprot
O14632
resolver
uniprot
Q2PBG4
resolver
uniprot
Q2PBG5
resolver
uniprot
Q92632
resolver
uniprot
Q9HAS2
resolver
uniprot_entry
A8KAE4_HUMAN
resolver
uniprot_entry
HIPK3_HUMAN
resolver
uniprot_sec
O14632
resolver
uniprot_sec
Q2PBG4
resolver
uniprot_sec
Q2PBG5
resolver
uniprot_sec
Q92632
resolver
uniprot_sec
Q9HAS2
resolver
amino_acid_sequence
MASQVLVYPPYVYQTQSSAFCSVKKLKVEPSSCVFQERNYPRTYVNGRNFGNSHPPTKGSAFQTKIPFNRPRGHNFSLQTSAVVLKNTAGATKVIAAQAQQAHVQAPQIGAWRNRLHFLEGPQRCGLKRKSEELDNHSSAMQIVDELSILPAMLQTNMGNPVTVVTATTGSKQNCTTGEGDYQLVQHEVLCSMKNTYEVLDFLGRGTFGQVVKCWKRGTNEIVAIKILKNHPSYARQGQIEVSILARLSTENADEYNFVRAYECFQHRNHTCLVFEMLEQNLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVSKTVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNVGTKSTRFFCKETDMSHSGWRLKTLEEHEAETGMKSKEARKYIFNSLDDVAHVNTVMDLEGSDLLAEKADRREFVSLLKKMLLIDADLRITPAETLNHPFVNMKHLLDFPHSNHVKSCFHIMDICKSHLNSCDTNNHNKTSLLRPVASSSTATLTANFTKIGTLRSQALTTSAHSVVHHGIPLQAGTAQFGCGDAFQQTLIICPPAIQGIPATHGKPTSYSIRVDNTVPLVTQAPAVQPLQIRPGVLSQTWSGRTQQMLVPAWQQVTPLAPATTTLTSESVAGSHRLGDWGKMISCSNHYNSVMPQPLLTNQITLSAPQPVSVGIAHVVWPQPATTKKNKQCQNRGILVKLMEWEPGREEINAFSWSNSLQNTNIPHSAFISPKIINGKDVEEVSCIETQDNQNSEGEARNCCETSIRQDSDSSVSDKQRQTIIIADSPSPAVSVITISSDTDEEETSQRHSLRECKGSLDCEACQSTLNIDRMCSLSSPDSTLSTSSSGQSSPSPCKRPNSMSDEEQESSCDTVDGSPTSDSSGHDSPFAESTFVEDTHENTELVSSADTETKPAVCSVVVPPVELENGLNADEHMANTDSICQPLIKGRSAPGRLNQPSAVGTRQQKLTSAFQQQHLNFSQVQHFGSGHQEWNGNFGHRRQQAYIPTSVTSNPFTLSHGSPNHTAVHAHLAGNTHLGGQPTLLPYPSSATLSSAAPVAHLLASPCTSRPMLQHPTYNISHPSGIVHQVPVGLNPRLLPSPTIHQTQYKPIFPPHSYIAASPAYTGFPLSPTKLSQYPYM
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase involved in transcription regulation, apoptosis and steroidogenic gene expression. Phosphorylates JUN and RUNX2. Seems to negatively regulate apoptosis by promoting FADD phosphorylation. Enhances androgen receptor-mediated transcription. May act as a transcriptional corepressor for NK homeodomain transcription factors. The phosphorylation of NR5A1 activates SF1 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. In osteoblasts, supports transcription activation: phosphorylates RUNX2 that synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE). {ECO:0000269|PubMed:14766760, ECO:0000269|PubMed:17210646}.
uniprot
proteins
mass_dalton
133743
uniprot
proteins
mutagenesis
MUTAGEN 226; /note="K->R: Loss of kinase activity and impaired activation of SF1."; /evidence="ECO:0000269|PubMed:17210646
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated, but autophosphorylation is not required for catalytic activity. {ECO:0000250}.; PTM: May be sumoylated. {ECO:0000250}.
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
HIPK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10961991
uniprot
proteins
pubmed
11034606
uniprot
proteins
pubmed
14766760
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17210646
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
9373137
uniprot
proteins
pubmed
9725910
uniprot
proteins
sequence_length
1215
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11034606}. Nucleus {ECO:0000269|PubMed:11034606}.
uniprot
proteins