Atg4c
entrez
242557
canonical
uniprot
Q811C2
canonical
ensembl
ENSMUSG00000028550
resolver
ensp
ENSMUSP00000030279
resolver
ensp
ENSMUSP00000137035
resolver
ensp
ENSMUSP00000253918
resolver
ensp
ENSMUSP00000253919
resolver
ensp
ENSMUSP00000253920
resolver
ensp
ENSMUSP00000253921
resolver
ensp
ENSMUSP00000253923
resolver
ensp
ENSMUSP00000253924
resolver
enst
ENSMUST00000030279
resolver
enst
ENSMUST00000180278
resolver
genesymbol
Atg4c
resolver
genesymbol_syn
Apg4c
resolver
genesymbol_syn
Autl3
resolver
uniprot
B1ASJ9
resolver
uniprot
Q3UYA5
resolver
uniprot
Q6PD25
resolver
uniprot_entry
ATG4C_MOUSE
resolver
uniprot_entry
Q3UYA5_MOUSE
resolver
uniprot_sec
B1ASJ9
resolver
uniprot_sec
Q6PD25
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by N-ethylmaleimide. {ECO:0000250|UniProtKB:Q96DT6}.
uniprot
proteins
amino_acid_sequence
MEASGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDESKMLPARSGCAIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEASALTTDCGWGCTLRTGQMLLAQGLILHFLGRAWTWPDALHIENADSDSWTSNTVKKFTASFEASLSGDRELRTPAVSLKETSGKCPDDHAVRNEAYHRKIISWFGDSPVAVFGLHRLIEFGKKSGKKAGDWYGPAVVAHILRKAVEEARHPDLQGLTIYVAQDCTVYNSDVIDKQTDSVTAGDARDKAVIILVPVRLGGERTNTDYLEFVKGVLSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDFPLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFERASEEITKMLKISSKEKYPLFTFVNGHSKDFDFTSTAASEEDLFSEDERKNFKRFSTEEFVLL
uniprot
proteins
ec_number
3.4.22.-
uniprot
proteins
function
FUNCTION: Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins. The protease activity is required for proteolytic activation of ATG8 family proteins: cleaves the C-terminal amino acid of ATG8 proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine (By similarity). Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy (By similarity). In addition to the protease activity, also mediates delipidation of ATG8 family proteins. Catalyzes delipidation of PE-conjugated forms of ATG8 proteins during macroautophagy. Compared to ATG4B, the major protein for proteolytic activation of ATG8 proteins, shows weaker ability to cleave the C-terminal amino acid of ATG8 proteins, while it displays stronger delipidation activity. In contrast to other members of the family, weakly or not involved in phagophore growth during mitophagy (By similarity). {ECO:0000250|UniProtKB:Q96DT6, ECO:0000250|UniProtKB:Q9Y4P1}.
uniprot
proteins
mass_dalton
52056
uniprot
proteins
protein_family
Peptidase C54 family
uniprot
proteins
pubmed
12446702
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17442669
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
30808002
uniprot
proteins
pubmed
30808006
uniprot
proteins
sequence_length
458
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8BGE6}.
uniprot
proteins