AQP6
entrez
363
canonical
uniprot
Q13520
canonical
ensembl
ENSG00000086159
resolver
ensp
ENSP00000320247
resolver
enst
ENST00000315520
resolver
genesymbol
AQP6
resolver
genesymbol_syn
AQP2L
resolver
hgnc
HGNC:639
resolver
uniprot_entry
AQP6_HUMAN
resolver
amino_acid_sequence
MDAVEPGGRGWASMLACRLWKAISRALFAEFLATGLYVFFGVGSVMRWPTALPSVLQIAITFNLVTAMAVQVTWKASGAHANPAVTLAFLVGSHISLPRAVAYVAAQLVGATVGAALLYGVMPGDIRETLGINVVRNSVSTGQAVAVELLLTLQLVLCVFASTDSRQTSGSPATMIGISVALGHLIGIHFTGCSMNPARSFGPAIIIGKFTVHWVFWVGPLMGALLASLIYNFVLFPDTKTLAQRLAILTGTVEVGTGAGAGAEPLKKESQPGSGAVEMESV
uniprot
proteins
function
FUNCTION: Aquaporins form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient (PubMed:8812490). Unlike classical aquaporins, AQP6 is an intracellular channel with selective anion permeability, particularly for nitrate, and exhibits very low water permeability (By similarity). It may also facilitate the transport of gases, such as CO2 and NH4(+), as demonstrated in vitro (By similarity). {ECO:0000250|UniProtKB:Q9WTY0, ECO:0000269|PubMed:8812490}.
uniprot
proteins
mass_dalton
29370
uniprot
proteins
protein_family
MIP/aquaporin (TC 1.A.8) family
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
8812490
uniprot
proteins
sequence_length
282
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9WTY0}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 26..46; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P41181"; TRANSMEM 55..73; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P41181"; TRANSMEM 100..121; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P41181"; TRANSMEM 142..162; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P41181"; TRANSMEM 169..188; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P41181"; TRANSMEM 214..234; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P41181
uniprot
proteins