Hspb1
entrez
15507
canonical
uniprot
P14602
canonical
ensembl
ENSMUSG00000004951
resolver
ensp
ENSMUSP00000005077
resolver
genesymbol
Hspb1
resolver
genesymbol_syn
Hsp25
resolver
genesymbol_syn
Hsp27
resolver
uniprot
Q545F4
resolver
uniprot_entry
HSPB1_MOUSE
resolver
uniprot_entry
Q545F4_MOUSE
resolver
amino_acid_sequence
MTERRVPFSLLRSPSWEPFRDWYPAHSRLFDQAFGVPRLPDEWSQWFSAAGWPGYVRPLPAATAEGPAAVTLAAPAFSRALNRQLSSGVSEIRQTADRWRVSLDVNHFAPEELTVKTKEGVVEITGKHEERQDEHGYISRCFTRKYTLPPGVDPTLVSSSLSPEGTLTVEAPLPKAVTQSAEITIPVTFEARAQIGGPEAGKSEQSGAK
uniprot
proteins
function
FUNCTION: Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state. Plays a role in stress resistance and actin organization (PubMed:17661394). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (By similarity). {ECO:0000250|UniProtKB:P04792, ECO:0000269|PubMed:17661394}.
uniprot
proteins
mass_dalton
23014
uniprot
proteins
post_translational_modification
PTM: Phosphorylated upon exposure to protein kinase C activators and heat shock (By similarity). Phosphorylation by MAPKAPK2 and MAPKAPK3 in response to stress dissociates HSPB1 from large small heat-shock protein (sHsps) oligomers and impairs its chaperone activity and ability to protect against oxidative stress effectively. Phosphorylation by MAPKAPK5 in response to PKA stimulation induces F-actin rearrangement (PubMed:1332886, PubMed:1860870, PubMed:21575178, PubMed:8093612). {ECO:0000250|UniProtKB:P04792, ECO:0000269|PubMed:1332886, ECO:0000269|PubMed:1860870, ECO:0000269|PubMed:21575178, ECO:0000269|PubMed:8093612}.
uniprot
proteins
protein_family
Small heat shock protein (HSP20) family
uniprot
proteins
pubmed
10751411
uniprot
proteins
pubmed
11342557
uniprot
proteins
pubmed
11546764
uniprot
proteins
pubmed
1332886
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17661394
uniprot
proteins
pubmed
1860870
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21575178
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
2645135
uniprot
proteins
pubmed
8093612
uniprot
proteins
pubmed
8132504
uniprot
proteins
pubmed
8514193
uniprot
proteins
pubmed
8514194
uniprot
proteins
sequence_length
209
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P04792}. Nucleus {ECO:0000250|UniProtKB:P04792}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:P04792}. Note=Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. {ECO:0000250|UniProtKB:P04792}.
uniprot
proteins