C8b
entrez
313421
canonical
uniprot
P55314
canonical
ensembl
ENSRNOG00000007639
resolver
ensp
ENSRNOP00000010100
resolver
enst
ENSRNOT00000010100
resolver
genesymbol
C8b
resolver
uniprot
Q5EB58
resolver
uniprot_entry
CO8B_RAT
resolver
uniprot_sec
Q5EB58
resolver
activity_regulation
ACTIVITY REGULATION: Membrane attack complex (MAC) assembly is inhibited by CD59, thereby protecting self-cells from damage during complement activation. CD59 acts by binding to the beta-haipins of C8 (C8A and C8B), forming an intermolecular beta-sheet that prevents incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. MAC assembly is also inhibited by clusterin (CLU) chaperones that inhibit polymerization of C9. {ECO:0000250|UniProtKB:P07358}.
uniprot
proteins
amino_acid_sequence
MKTGAQVWRALAKSCLLCAALGCLHLPGARGEKPDFFETNAVNGSLVRSRPVRSVDVTPAPTDCQLSTWSSWTACDPCQKKRYRHTYLLRPSQFYGELCDFSDKEVEDCVTNRACRSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRRIYKKCSQDMEQYWAIGNLASGINLFTNTFEGPVLDHRYYAGACSPHYILNTNFRKPYNVESYTPQTQGKYEFALTEYESYFDFEHNVTEKATSKSSFKFGFKLDGLVEFGVRKESNEGRHYISRTKRFSHTKSKFLHARSVLEVAHYKLKSRQLMLHYEFLQRVKSLPLEYSYGEYRDLLRDFGTHFITEAVLGGIYEYTLIMNKDAMERGDYTLDHVSACAGGGFQIGGNVYKVYLKLGVSEKKCSDILNEIKDRNKRRTMVEDLVVLVRGGTSEYITSLAYKDLPTAELMKEWGDAVQYNPAIIKLKAEPLYELVTATDFAYSSTVKQNMKKALEEFQMEVSSCRCAPCRNNGVPILKESRCECICPAGFQGVACEVTNRKDIPIDGKWSCWSDWSPCSGGRKTRQRQCNNPAPQRGGSPCSGPASETLDC
uniprot
proteins
function
FUNCTION: Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis. The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways. The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. C8B, together with C8A and C8G, inserts into the target membrane, but does not form pores by itself. During MAC assembly, associates with C5b, C6 and C7 to form the C5b8 intermediate complex that inserts into the target membrane and traverses the bilayer increasing membrane rigidity. {ECO:0000250|UniProtKB:P07358}.
uniprot
proteins
mass_dalton
66667
uniprot
proteins
post_translational_modification
PTM: N-glycosylated; contains one or two bound glycans. Not O-glycosylated. {ECO:0000250|UniProtKB:P07358}.
uniprot
proteins
protein_family
Complement C6/C7/C8/C9 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7665162
uniprot
proteins
sequence_length
589
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P07358}. Target cell membrane {ECO:0000250|UniProtKB:P07358}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P07358}. Note=Secreted as soluble protein. Inserts into the cell membrane of target cells. {ECO:0000250|UniProtKB:P07358}.
uniprot
proteins
transmembrane_region
TRANSMEM 251..258; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:P07358"; TRANSMEM 261..268; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:P07358"; TRANSMEM 378..385; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:P07358"; TRANSMEM 391..398; /note="Beta stranded"; /evidence="ECO:0000250|UniProtKB:P07358
uniprot
proteins