Arhgef15
entrez
442801
canonical
uniprot
Q5FWH6
canonical
ensembl
ENSMUSG00000052921
resolver
ensp
ENSMUSP00000282474
resolver
ensp
ENSMUSP00000282476
resolver
ensp
ENSMUSP00000282477
resolver
ensp
ENSMUSP00000282480
resolver
ensp
ENSMUSP00000282481
resolver
genesymbol
Arhgef15
resolver
genesymbol_syn
Kiaa0915
resolver
uniprot
Q14B44
resolver
uniprot
Q69ZV7
resolver
uniprot_entry
ARHGF_MOUSE
resolver
uniprot_sec
Q14B44
resolver
uniprot_sec
Q69ZV7
resolver
amino_acid_sequence
MSAQSLPAATPPTLKPPRIIRPRPPSRHRAPHSPGPLHNGSSPKALPQISNDASASVCTSIFWEPPTASLKPPALLPPSVSRTSLDSQTSPDSPSSTPSPSPVSRRSISPEPAPCSPVPPPKPSGSSRTPLPSGPTPLQDGSASAPGTVRRLAGKFEWGAEGKAQSSDSLERCSQGSTEVNGEKETPEAALSGNGSQENGTPDAALACPPCCPCVCHVAKPGLELRWVPVGSSEDILRIPCRASPLRASRSRINPPVISHPPVVLTSYRSTAERKLLPPLKPPKPTKVRQDISTSEELPQPDLKLPSEDGIQTATKAWEGDRPEGAPLNAPPVALEGREEEGLDGLKGLQWELPLQDEPLYQTYRAAVLSEELWGVGEDGGPSPANPGEAPTFSRLPGPRNTLWQELPAVRGSGLLESLSPQERRMQESLFEVVTSEASYLRSLRLLTDTFVLSQALRDTLTPRDHHTLFSNVQRVQSVSERFLGTLLSRVRSSPHITDLCDVVHAHAVGPFFVYVDYVRNQQYQEETYSRLMDTNVRFSAELRRLQSLPKCERLPLPSFLLLPFQRITRLRMLLQNILSQTEEGSSRQENAQKALGAVSKIIERCSAEVGRMKQTEELIRLTQRLRFHKVKALPLVSWSRRLELQGELTELGCRRGGVLFTSRPRFTPLCLLLFSDLLLITQPKSGQRLQVLDYAHRSLVQAQQVPDPSGPPTFRLSLLSNHQGRPTHRLLQAASLSDMQRWLGAFPTPGPLPCSPDTIYEDCECSQELCSEPSTPSKTEGQSLESKAPRKHLHKNPEGWLKGLPGAFPAQLVCEVTGEHERRKHLRQHQKLLEAVGPSSGTPDTPQP
uniprot
proteins
function
FUNCTION: Guanine nucleotide exchange factor (GEF) that activates RhoA, playing a role in the regulation of actin cytoskeleton organization (PubMed:36929019). Is involved in the regulation of vascular smooth muscle contractility (By similarity). In addition to this process, it negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2 (PubMed:21029865). Does not activate RAC1 or CDC42. {ECO:0000250|UniProtKB:O94989, ECO:0000269|PubMed:21029865, ECO:0000269|PubMed:36929019}.
uniprot
proteins
mass_dalton
92946
uniprot
proteins
mutagenesis
MUTAGEN 361; /note="Y->A: Abolishes phosphorylation by EPHB2."; /evidence="ECO:0000269|PubMed:21029865"; MUTAGEN 368; /note="V->M: Mutant mice show features of cerebral small vessel disease including cerebral microinfarction, disruption of the blood-brain barrier, abnormal walls of cerebral small vessels, and behavioral abnormalities. Mutant mice have lower trabecular bone density."; /evidence="ECO:0000269|PubMed:36929019"; MUTAGEN 547..548; /note="QS->AA: No effect on RHOA activation; when associated with 554-A-A-555."; /evidence="ECO:0000269|PubMed:21029865"; MUTAGEN 554..555; /note="RL->AA: No effect on RHOA activation; when associated with 547-A-A-548."; /evidence="ECO:0000269|PubMed:21029865"; MUTAGEN 562; /note="L->A: Impairs RHOA activation; when associated with 566-A-A-567."; /evidence="ECO:0000269|PubMed:21029865"; MUTAGEN 566..567; /note="QR->AA: Impairs RHOA activation; when associated with A-562."; /evidence="ECO:0000269|PubMed:21029865
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues upon EFNA1 stimulation. EPHB2-dependent phosphorylation at Tyr-361 triggers UBE3A-mediated ubiquitination. {ECO:0000269|PubMed:21029865}.; PTM: Ubiquitinated; UBE3A-mediated ubiquitination and degradation by the proteasome promotes EFNB1-dependent synapse formation. {ECO:0000269|PubMed:21029865}.
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15848799
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21029865
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
36929019
uniprot
proteins
sequence_length
849
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, dendrite {ECO:0000269|PubMed:21029865}. Note=Expressed exclusively in dendrites of the developing hippocampus.
uniprot
proteins