P29533
uniprot
P29533
canonical
amino_acid_sequence
MPVKMVAVLGASTVLWILFAVSQAFKIEISPEYKTIAQIGDSMALTCSTTGCESPLFSWRTQIDSPLNAKVRTEGSKSVLTMEPVSFENEHSYLCTATCGSGKLERSIHVDIYSFPKDPEIQFSGPLEVGKPVTVKCLAPDIYPVYRLEIDLFKGDQLMNRQEFSSEEMTKSLETKSLEVTFTPVIEDIGKALVCRAKLHIDQIDSTLKERETVKELQVYISPRNTTISVHPSTRLQEGGAVTMTCSSEGLPAPEIFWGRKLDNEVLQLLSGNATLTLIAMRMEDSGVYVCEGVNLIGRDKAEVELVVQEKPFIVDISPGSQVAAQVGDSVVLTCAAIGCDSPSFSWRTQTDSPLNGVVRNEGAKSTLVLSSVGFEDEHSYLCAVTCLQRTLEKRTQVEVYSFPEDPVIKMSGPLVHGRPVTVNCTVPNVYPFDHLEIELLKGETTLMKKYFLEEMGIKSLETKILETTFIPTIEDTGKSLVCLARLHSGEMESEPKQRQSVQPLYVNVAPKETTIWVSPSPILEEGSPVNLTCSSDGIPAPKILWSRQLNNGELQPLSENTTLTFMSTKRDDSGIYVCEGINEAGISRKSVELIIQVSPKDIQLTVFPSKSVKEGDTVIISCTCGNVPETWIILKKKAKTGDMVLKSVDGSYTIRQAQLQDAGIYECESKTEVGSQLRSLTLDVKGKEHNKDYFSPELLALYCASSLVIPAIGMIVYFARKANMKGSYSLVEAQKSKV
uniprot
proteins
function
FUNCTION: Cell adhesion glycoprotein predominantly expressed on the surface of endothelial cells that plays an important role in immune surveillance and inflammation. Acts as a major regulator of leukocyte adhesion to the endothelium through interaction with different types of integrins. During inflammatory responses, binds ligands on the surface of activated endothelial cells to initiate the activation of calcium channels and the plasma membrane-associated small GTPase RAC1 leading to leukocyte transendothelial migration. Also serves as a quality-control checkpoint for entry into bone marrow by providing a 'don't-eat-me' stamping in the context of major histocompatibility complex (MHC) class-I presentation. {ECO:0000250|UniProtKB:P19320}.
uniprot
proteins
mass_dalton
81317
uniprot
proteins
post_translational_modification
PTM: Cleaved by the metalloproteinase ADAM17 to generate the soluble form. {ECO:0000250|UniProtKB:P19320}.; PTM: Sialoglycoprotein. {ECO:0000250|UniProtKB:P19320}.; PTM: Ubiquitinated by TRIM65 via 'Lys-48'-linked ubiquitination; leading to proteasomal degradation. {ECO:0000250|UniProtKB:P19320}.
uniprot
proteins
pubmed
1371918
uniprot
proteins
pubmed
1713592
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7507076
uniprot
proteins
pubmed
7514674
uniprot
proteins
pubmed
7523515
uniprot
proteins
pubmed
7682556
uniprot
proteins
pubmed
7683304
uniprot
proteins
pubmed
7687058
uniprot
proteins
sequence_length
739
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Vascular cell adhesion protein 1]: Cell membrane {ECO:0000250|UniProtKB:P19320}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P19320}.; SUBCELLULAR LOCATION: [Soluble Vascular Cell Adhesion Molecule-1]: Secreted {ECO:0000250|UniProtKB:P19320}.
uniprot
proteins
transmembrane_region
TRANSMEM 699..720; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins