EYA3
entrez
2140
canonical
uniprot
Q99504
canonical
ensembl
ENSG00000158161
resolver
ensp
ENSP00000362970
resolver
ensp
ENSP00000362978
resolver
ensp
ENSP00000405587
resolver
ensp
ENSP00000442558
resolver
ensp
ENSP00000568760
resolver
ensp
ENSP00000568764
resolver
ensp
ENSP00000601367
resolver
ensp
ENSP00000758759
resolver
enst
ENST00000436342
resolver
genesymbol
EYA3
resolver
hgnc
HGNC:3521
resolver
uniprot
A8K190
resolver
uniprot
B4DIR7
resolver
uniprot
B4DNZ7
resolver
uniprot
O95463
resolver
uniprot
Q8IVX7
resolver
uniprot
Q99813
resolver
uniprot_entry
EYA3_HUMAN
resolver
uniprot_sec
A8K190
resolver
uniprot_sec
B4DIR7
resolver
uniprot_sec
B4DNZ7
resolver
uniprot_sec
O95463
resolver
uniprot_sec
Q8IVX7
resolver
uniprot_sec
Q99813
resolver
amino_acid_sequence
MEEEQDLPEQPVKKAKMQESGEQTISQVSNPDVSDQKPETSSLASNLPMSEEIMTCTDYIPRSSNDYTSQMYSAKPYAHILSVPVSETAYPGQTQYQTLQQTQPYAVYPQATQTYGLPPFGALWPGMKPESGLIQTPSPSQHSVLTCTTGLTTSQPSPAHYSYPIQASSTNASLISTSSTIANIPAAAVASISNQDYPTYTILGQNQYQACYPSSSFGVTGQTNSDAESTTLAATTYQSEKPSVMAPAPAAQRLSSGDPSTSPSLSQTTPSKDTDDQSRKNMTSKNRGKRKADATSSQDSELERVFLWDLDETIIIFHSLLTGSYAQKYGKDPTVVIGSGLTMEEMIFEVADTHLFFNDLEECDQVHVEDVASDDNGQDLSNYSFSTDGFSGSGGSGSHGSSVGVQGGVDWMRKLAFRYRKVREIYDKHKSNVGGLLSPQRKEALQRLRAEIEVLTDSWLGTALKSLLLIQSRKNCVNVLITTTQLVPALAKVLLYGLGEIFPIENIYSATKIGKESCFERIVSRFGKKVTYVVIGDGRDEEIAAKQHNMPFWRITNHGDLVSLHQALELDFL
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (PubMed:19234442, PubMed:19351884). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye. {ECO:0000250|UniProtKB:P97480, ECO:0000269|PubMed:19234442, ECO:0000269|PubMed:19351884}.
uniprot
proteins
mass_dalton
62663
uniprot
proteins
mutagenesis
MUTAGEN 266; /note="S->A: Fails to form damage-dependent nuclear foci or interact with H2AX."; /evidence="ECO:0000269|PubMed:19234442"; MUTAGEN 309; /note="D->A: Loss of tyrosine phosphatase activity toward H2AX."; /evidence="ECO:0000269|PubMed:19234442
uniprot
proteins
post_translational_modification
PTM: Ser-266 phosphorylation is required for localization at sites of DNA damage and directing interaction with H2AX. {ECO:0000269|PubMed:19234442}.
uniprot
proteins
protein_family
EYA family
uniprot
proteins
protein_family
HAD-like hydrolase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
19234442
uniprot
proteins
pubmed
19351884
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
9020840
uniprot
proteins
pubmed
9049631
uniprot
proteins
pubmed
9887327
uniprot
proteins
sequence_length
573
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P97480}. Nucleus {ECO:0000269|PubMed:19234442}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs) (PubMed:19234442). With decreasing efficiency, translocalized to the nucleus by SIX2 and SIX5, and SIX4, respectively (By similarity). {ECO:0000250|UniProtKB:P97480, ECO:0000269|PubMed:19234442}.
uniprot
proteins