Tyrobp
entrez
361537
canonical
uniprot
Q6X9T7
canonical
ensembl
ENSRNOG00055031150
resolver
ensembl
ENSRNOG00060029543
resolver
ensembl
ENSRNOG00065031519
resolver
ensp
ENSRNOP00055044702
resolver
ensp
ENSRNOP00060042660
resolver
ensp
ENSRNOP00065044682
resolver
enst
ENSRNOT00055054024
resolver
enst
ENSRNOT00060051281
resolver
enst
ENSRNOT00065054313
resolver
genesymbol
Tyrobp
resolver
genesymbol_syn
Dap12
resolver
uniprot_entry
TYOBP_RAT
resolver
amino_acid_sequence
MGAPEPSWCFLFLPVLLTVGGLSPVQAQSDNYPGCECSSVSPGVLAGIVLGDLVLTLLIALAVYSLGRLVSRGRGTADGTRKQHMAETESPYQELQGQRPEVYSDLNTQRQYYR
uniprot
proteins
function
FUNCTION: Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors (By similarity). TYROBP is tyrosine-phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation (By similarity). Also has an inhibitory role in some cells (By similarity). Non-covalently associates with activating receptors of the CD300 family to mediate cell activation (By similarity). Also mediates cell activation through association with activating receptors of the CD200R family (By similarity). Required for neutrophil activation mediated by integrin (By similarity). Required for the activation of myeloid cells mediated by the CLEC5A/MDL1 receptor (By similarity). Associates with natural killer (NK) cell receptors such as the KLRD1/KLRC2 heterodimer to mediate NK cell activation (By similarity). Associates with TREM1 to mediate activation of neutrophils and monocytes (By similarity). Associates with TREM2 on monocyte-derived dendritic cells to mediate up-regulation of chemokine receptor CCR7 and dendritic cell maturation and survival (By similarity). PAssociation with TREM2 mediates cytokine-induced formation of multinucleated giant cells which are formed by the fusion of macrophages (By similarity). Stabilizes the TREM2 C-terminal fragment (TREM2-CTF) produced by TREM2 ectodomain shedding which suppresses the release of pro-inflammatory cytokines (By similarity). In microglia, required with TREM2 for phagocytosis of apoptotic neurons (By similarity). Required with ITGAM/CD11B in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development (By similarity). Promotes pro-inflammatory responses in microglia following nerve injury which accelerates degeneration of injured neurons (By similarity). ositively regulates the expression of the IRAK3/IRAK-M kinase and IL10 production by liver dendritic cells and inhibits their T cell allosimulatory ability (By similarity). Negatively regulates B cell proliferation (By similarity). Required for CSF1-mediated osteoclast cytoskeletal organization (By similarity). Positively regulates multinucleation during osteoclast development (By similarity). {ECO:0000250|UniProtKB:O43914, ECO:0000250|UniProtKB:O54885}.
uniprot
proteins
mass_dalton
12361
uniprot
proteins
post_translational_modification
PTM: Following ligand binding by associated receptors, tyrosine phosphorylated in the ITAM domain which leads to activation of additional tyrosine kinases and subsequent cell activation. {ECO:0000250|UniProtKB:O43914}.
uniprot
proteins
protein_family
TYROBP family
uniprot
proteins
sequence_length
114
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O43914}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 43..63; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O43914
uniprot
proteins