RER1
entrez
11079
canonical
uniprot
O15258
canonical
ensembl
ENSG00000157916
resolver
ensp
ENSP00000464222
resolver
ensp
ENSP00000475168
resolver
ensp
ENSP00000544528
resolver
ensp
ENSP00000544529
resolver
ensp
ENSP00000544530
resolver
ensp
ENSP00000544531
resolver
ensp
ENSP00000544532
resolver
ensp
ENSP00000544533
resolver
ensp
ENSP00000544534
resolver
ensp
ENSP00000544535
resolver
ensp
ENSP00000544536
resolver
ensp
ENSP00000544537
resolver
ensp
ENSP00000544538
resolver
ensp
ENSP00000544539
resolver
ensp
ENSP00000544540
resolver
ensp
ENSP00000544541
resolver
ensp
ENSP00000544542
resolver
ensp
ENSP00000544544
resolver
ensp
ENSP00000544545
resolver
ensp
ENSP00000590675
resolver
ensp
ENSP00000590676
resolver
ensp
ENSP00000590677
resolver
ensp
ENSP00000590678
resolver
ensp
ENSP00000590679
resolver
ensp
ENSP00000590680
resolver
ensp
ENSP00000590681
resolver
ensp
ENSP00000590682
resolver
ensp
ENSP00000590683
resolver
ensp
ENSP00000590687
resolver
ensp
ENSP00000590688
resolver
ensp
ENSP00000590689
resolver
ensp
ENSP00000624724
resolver
ensp
ENSP00000624725
resolver
ensp
ENSP00000624726
resolver
ensp
ENSP00000624727
resolver
ensp
ENSP00000624728
resolver
ensp
ENSP00000624729
resolver
enst
ENST00000488353
resolver
enst
ENST00000605895
resolver
enst
ENST00000874469
resolver
enst
ENST00000874470
resolver
enst
ENST00000874471
resolver
enst
ENST00000874472
resolver
enst
ENST00000874473
resolver
enst
ENST00000874474
resolver
enst
ENST00000874475
resolver
enst
ENST00000874476
resolver
enst
ENST00000874477
resolver
enst
ENST00000874478
resolver
enst
ENST00000874479
resolver
enst
ENST00000874480
resolver
enst
ENST00000874481
resolver
enst
ENST00000874482
resolver
enst
ENST00000874483
resolver
enst
ENST00000874485
resolver
enst
ENST00000874486
resolver
enst
ENST00000920616
resolver
enst
ENST00000920617
resolver
enst
ENST00000920618
resolver
enst
ENST00000920619
resolver
enst
ENST00000920620
resolver
enst
ENST00000920621
resolver
enst
ENST00000920622
resolver
enst
ENST00000920623
resolver
enst
ENST00000920624
resolver
enst
ENST00000920628
resolver
enst
ENST00000920629
resolver
enst
ENST00000920630
resolver
enst
ENST00000954665
resolver
enst
ENST00000954666
resolver
enst
ENST00000954667
resolver
enst
ENST00000954668
resolver
enst
ENST00000954669
resolver
enst
ENST00000954670
resolver
genesymbol
RER1
resolver
hgnc
HGNC:30309
resolver
uniprot
A0A024R0A5
resolver
uniprot
O95322
resolver
uniprot
Q5T094
resolver
uniprot_entry
Q5T094_HUMAN
resolver
uniprot_entry
RER1_HUMAN
resolver
uniprot_sec
A0A024R0A5
resolver
uniprot_sec
O95322
resolver
amino_acid_sequence
MSEGDSVGESVHGKPSVVYRFFTRLGQIYQSWLDKSTPYTAVRWVVTLGLSFVYMIRVYLLQGWYIVTYALGIYHLNLFIAFLSPKVDPSLMEDSDDGPSLPTKQNEEFRPFIRRLPEFKFWHAATKGILVAMVCTFFDAFNVPVFWPILVMYFIMLFCITMKRQIKHMIKYRYIPFTHGKRRYRGKEDAGKAFAS
uniprot
proteins
function
FUNCTION: Involved in the retention or retrieval of proteins localized in the endoplasmic reticulum from the early Golgi compartment, including the gamma-secretase complex subunit PEN-2 (PSENEN) (PubMed:17668005). Regulates intracellular trafficking of the gamma-secretase complex and amyloid-beta precursor protein (APP), thereby controlling APP levels at the cell surface and influencing the release of amyloid-beta peptides generated through gamma-secretase mediated processing of APP (PubMed:23043097). During cerebral cortex and neural stem cell development, it is required to maintain sufficient expression and activity of gamma-secretase complex at the cell surface, modulating NOTCH processing and signaling (By similarity). In addition to its role in the control of protein trafficking, the RER1-dependent Golgi apparatus-endoplasmic reticulum retrieval system may regulate proteasomal degradation of alpha-synuclein (SNCA) (PubMed:17668005, PubMed:23043097, PubMed:28877262). {ECO:0000250|UniProtKB:Q9CQU3, ECO:0000269|PubMed:17668005, ECO:0000269|PubMed:23043097, ECO:0000269|PubMed:28877262}.
uniprot
proteins
mass_dalton
22958
uniprot
proteins
mutagenesis
MUTAGEN 2..25; /note="Missing: Does not localize to the cis-Golgi network."; /evidence="ECO:0000269|PubMed:28877262
uniprot
proteins
protein_family
RER1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17668005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23043097
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25489052
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28877262
uniprot
proteins
pubmed
9309388
uniprot
proteins
sequence_length
196
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:9309388}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:28877262}.
uniprot
proteins
transmembrane_region
TRANSMEM 41..61; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 63..83; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 118..138; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 140..160; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins