CAVIN2
entrez
8436
canonical
uniprot
O95810
canonical
ensembl
ENSG00000168497
resolver
ensp
ENSP00000305675
resolver
enst
ENST00000304141
resolver
genesymbol
CAVIN2
resolver
genesymbol_syn
SDPR
resolver
hgnc
HGNC:10690
resolver
uniprot_entry
CAVN2_HUMAN
resolver
amino_acid_sequence
MGEDAAQAEKFQHPGSDMRQEKPSSPSPMPSSTPSPSLNLGNTEEAIRDNSQVNAVTVLTLLDKLVNMLDAVQENQHKMEQRQISLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRKVSAHTRAVKERMDRQCAQVKRLENNHAQLLRRNHFKVLIFQEENEIPASVFVKQPVSGAVEGKEELPDENKSLEETLHTVDLSSDDDLPHDEEALEDSAEEKVEESRAEKIKRSSLKKVDSLKKAFSRQNIEKKMNKLGTKIVSVERREKIKKSLTSNHQKISSGKSSPFKVSPLTFGRKKVREGESHAENETKSEDLPSSEQMPNDQEEESFAEGHSEASLASALVEGEIAEEAAEKATSRGSNSGMDSNIDLTIVEDEEEESVALEQAQKVRYEGSYALTSEEAERSDGDPVQPAVLQVHQTS
uniprot
proteins
function
FUNCTION: Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (PubMed:19525939). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells. May play a role in targeting PRKCA to caveolae (By similarity). {ECO:0000250|UniProtKB:Q66H98, ECO:0000269|PubMed:19525939}.
uniprot
proteins
mass_dalton
47173
uniprot
proteins
mutagenesis
MUTAGEN 86; /note="L->E: Loss of localization in caveolae; when associated with E-93 or E-100."; /evidence="ECO:0000269|PubMed:19262564"; MUTAGEN 93; /note="I->E: Loss of localization in caveolae; when associated with E-86 or E-100."; /evidence="ECO:0000269|PubMed:19262564"; MUTAGEN 100; /note="L->E: Loss of localization in caveolae; when associated with E-86 or E-93."; /evidence="ECO:0000269|PubMed:19262564
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser residues. {ECO:0000269|PubMed:2390065}.
uniprot
proteins
protein_family
CAVIN family
uniprot
proteins
pubmed
10191091
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18332105
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19262564
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19525939
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2390065
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24567387
uniprot
proteins
pubmed
26614875
uniprot
proteins
sequence_length
425
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10191091, ECO:0000269|PubMed:2390065}. Membrane, caveola {ECO:0000269|PubMed:19262564, ECO:0000269|PubMed:19525939}. Note=Localizes in the caveolae in a caveolin-dependent manner. {ECO:0000269|PubMed:19262564}.
uniprot
proteins