Slc5a7
entrez
85426
canonical
uniprot
Q9JMD7
canonical
ensembl
ENSRNOG00000010597
resolver
ensp
ENSRNOP00000014548
resolver
enst
ENSRNOT00000014548
resolver
genesymbol
Slc5a7
resolver
genesymbol_syn
Cht1
resolver
uniprot
G3V7G1
resolver
uniprot_entry
G3V7G1_RAT
resolver
uniprot_entry
SC5A7_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Choline uptake activity is regulated by SLC5A7/CHT1 internalization (inactive form) from the cell surface and recycling of internalized SLC5A7/CHT1 into the cell surface (active form) (By similarity). Activated by extracellular chloride ion (By similarity). Specifically inhibited by nanomolar concentrations of hemicholinium 3 (PubMed:10649566). {ECO:0000250|UniProtKB:Q9GZV3, ECO:0000269|PubMed:10649566}.
uniprot
proteins
amino_acid_sequence
MPFHVEGLVAIILFYLLIFLVGIWAAWKTKNSGNAEERSEAIIVGGRDIGLLVGGFTMTATWVGGGYINGTAEAVYGPGCGLAWAQAPIGYSLSLILGGLFFAKPMRSKGYVTMLDPFQQIYGKRMGGLLFIPALMGEMFWAAAIFSALGATISVIIDVDVNISVIVSALIAILYTLVGGLYSVAYTDVVQLFCIFIGLWISVPFALSHPAVTDIGFTAVHAKYQSPWLGTIESVEVYTWLDNFLLLMLGGIPWQAYFQRVLSSSSATYAQVLSFLAAFGCLVMALPAICIGAIGASTDWNQTAYGFPDPKTKEEADMILPIVLQYLCPVYISFFGLGAVSAAVMSSADSSILSASSMFARNIYQLSFRQNASDKEIVWVMRITVFVFGASATAMALLTKTVYGLWYLSSDLVYIIIFPQLLCVLFIKGTNTYGAVAGYIFGLFLRITGGEPYLYLQPLIFYPGYYPDKNGIYNQRFPFKTLSMVTSFFTNICVSYLAKYLFESGTLPPKLDIFDAVVSRHSEENMDKTILVRNENIKLNELAPVKPRQSLTLSSTFTNKEALLDVDSSPEGSGTEDNLQ
uniprot
proteins
function
FUNCTION: High-affinity Na(+)-coupled choline transmembrane symporter (PubMed:10649566). Functions as an electrogenic, voltage-dependent transporter with variable charge/choline stoichiometry (By similarity). Choline uptake and choline-induced current is also Cl(-)-dependent where Cl(-) is likely a regulatory ion rather than cotransported ion (By similarity). Plays a critical role in acetylcholine (ACh) synthesis by taking up the substrate choline from the synaptic cleft into the presynaptic nerve terminals after neurotransmitter release (By similarity). SLC5A7/CHT1-mediated choline high-affinity transport in cholinergic neurons is the rate-limiting step for production of ACh, thereby facilitating communication by subsequent action potentials (By similarity). Localized predominantly in presynaptic terminal intracellular organelles, and translocated to the plasma membrane in active form in response to neuronal activity (By similarity). {ECO:0000250|UniProtKB:Q8BGY9, ECO:0000250|UniProtKB:Q9GZV3, ECO:0000269|PubMed:10649566}.
uniprot
proteins
mass_dalton
63407
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250|UniProtKB:Q8BGY9}.
uniprot
proteins
protein_family
Sodium:solute symporter (SSF) (TC 2.A.21) family
uniprot
proteins
pubmed
10649566
uniprot
proteins
pubmed
12969261
uniprot
proteins
pubmed
17092608
uniprot
proteins
sequence_length
580
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Presynaptic cell membrane {ECO:0000250|UniProtKB:Q9GZV3}; Multi-pass membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000250|UniProtKB:Q8BGY9}. Early endosome membrane {ECO:0000250|UniProtKB:Q9GZV3}; Multi-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:12969261}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to synaptic vesicles. {ECO:0000269|PubMed:12969261}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..27; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 49..69; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 82..102; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 126..146; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 165..185; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 192..212; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 238..258; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 275..295; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 318..338; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 377..397; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 407..427; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 436..456; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 482..502; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins