Brat1
entrez
231841
canonical
uniprot
Q8C3R1
canonical
ensembl
ENSMUSG00000000148
resolver
ensp
ENSMUSP00000036016
resolver
ensp
ENSMUSP00000098074
resolver
ensp
ENSMUSP00000268595
resolver
ensp
ENSMUSP00000268598
resolver
ensp
ENSMUSP00000268599
resolver
ensp
ENSMUSP00000268610
resolver
enst
ENSMUST00000100505
resolver
genesymbol
Brat1
resolver
genesymbol_syn
Baat1
resolver
uniprot
E9QLK3
resolver
uniprot
Q3TDC8
resolver
uniprot
Q3U442
resolver
uniprot
Q6NV65
resolver
uniprot
Q8C3T3
resolver
uniprot
Q9JKU7
resolver
uniprot_entry
BRAT1_MOUSE
resolver
uniprot_entry
E9QLK3_MOUSE
resolver
uniprot_sec
Q3TDC8
resolver
uniprot_sec
Q3U442
resolver
uniprot_sec
Q6NV65
resolver
uniprot_sec
Q8C3T3
resolver
uniprot_sec
Q9JKU7
resolver
amino_acid_sequence
MDPECSRLLPALCAVLADPRQLVADDTCLEKLLDWFKTVTEAESSLQLLQDHPCLMELLSHVLKPQDVSPRVLSFALRLVGVFAAQEDCFEYLQQGELLLGLFGESGAPGWAAWSIPSVRSGWIQGLCYLAHHPSALHFLADSGAVDTLFSLQGDPSLFVASAASQLLVHILALSMQGGAPGSPVPEAAAWPMCAQKIVNHVDESLHAKATPQVTQALNVLTTTFGRCHNPWTGVLWERLSPPVARLFERDPIPAVHALMDLLLSVARSPVLNFAACGLWEMLAQTLSRLSPIQAGPLALGTLKLQHCPQELRTQAFGVLLQPLACILKATTQAPGPPGLLDGTVGSLLTVDILLASKSACVGLLCQTLAHLEELQMLPQCPSPWPQVHLLQAALTILHLCDGSADPSSSAGGRLCGTLGGCVRVQRAALDFLGTLSQGTSPLELVLEVFAVLLKTLESPESSPMVLKKAFQATLRWLQNPHKTPSSSDLSSDALLFLGELFPILQKRLCSPCWEVRDSALEFLTHLIRHWGGQADFREALRSSEVPTLALQLLQDPESYVRASAVGAAGQLSSQGLQAAPASPENSQAQQGLLMDLMHILSTDSEGFPRRAVLRVFTDWLRDGHADVVRDTEWFVATVLQAVSRDLDWEVRVQGLELARVFLTQALGQPSLHCPYTVGLPRASSPRPHPEFLQTLCRLPLFEFAFCALLDCDRPVAQKACDLLLFLRDKTVPCSSPREAGDSPNSASVEAALQRWREGEQAQPLGDLDPEAMLAILRALDLEGLQGRLAKSSDHVEKSPQSLLQDMLATVGVLEENEADCY
uniprot
proteins
function
FUNCTION: Component of a multiprotein complex required for the assembly of the RNA endonuclease module of the integrator complex (By similarity). Associates with INTS9 and INTS11 in the cytoplasm and blocks the active site of INTS11 to inhibit the endonuclease activity of INTS11 before formation of the full integrator complex (By similarity). Following dissociation of WDR73 of the complex, BRAT1 facilitates the nuclear import of the INTS9-INTS11 heterodimer (By similarity). In the nucleus, INTS4 is integrated to the INTS9-INTS11 heterodimer and BRAT1 is released from the mature RNA endonuclease module by inositol hexakisphosphate (InsP6) (By similarity). BRAT1 is also involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress (By similarity). Plays a role in regulating mitochondrial function and cell proliferation (By similarity). Required for protein stability of MTOR and MTOR-related proteins, and cell cycle progress by growth factors (PubMed:25657994). {ECO:0000250|UniProtKB:Q6PJG6, ECO:0000269|PubMed:25657994}.
uniprot
proteins
mass_dalton
89086
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by NEDD4, NEDD4L and ITCH; mono- and polyubiquitinated forms are detected. {ECO:0000250|UniProtKB:Q6PJG6}.
uniprot
proteins
protein_family
BRAT1 family
uniprot
proteins
pubmed
10693804
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22977523
uniprot
proteins
pubmed
25631046
uniprot
proteins
pubmed
25657994
uniprot
proteins
sequence_length
822
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25631046}. Cytoplasm {ECO:0000269|PubMed:25631046}. Note=Present at double strand breaks (DSBs) following ionizing radiation treatment (By similarity). The ubiquitinated form localizes in the nucleus in a NDFIP1-dependent manner. {ECO:0000250|UniProtKB:Q6PJG6, ECO:0000269|PubMed:25631046}.
uniprot
proteins