Il3ra
entrez
16188
canonical
uniprot
P26952
canonical
ensembl
ENSMUSG00000068758
resolver
ensp
ENSMUSP00000088079
resolver
ensp
ENSMUSP00000153086
resolver
ensp
ENSMUSP00000310790
resolver
ensp
ENSMUSP00000310791
resolver
ensp
ENSMUSP00000310792
resolver
ensp
ENSMUSP00000310793
resolver
ensp
ENSMUSP00000310794
resolver
ensp
ENSMUSP00000310795
resolver
ensp
ENSMUSP00000310797
resolver
genesymbol
Il3ra
resolver
genesymbol_syn
Sut-1
resolver
uniprot
B9VI80
resolver
uniprot_entry
IL3RA_MOUSE
resolver
uniprot_sec
B9VI80
resolver
amino_acid_sequence
MAANLWLILGLLASHSSDLAAVREAPPTAVTTPIQNLHIDPAHYTLSWDPAPGADITTGAFCRKGRDIFVWADPGLARCSFQSLSLCHVTNFTVFLGKDRAVAGSIQFPPDDDGDHEAAAQDLRCWVHEGQLSCQWERGPKATGDVHYRMFWRDVRLGPAHNRECPHYHSLDVNTAGPAPHGGHEGCTLDLDTVLGSTPNSPDLVPQVTITVNGSGRAGPVPCMDNTVDLQRAEVLAPPTLTVECNGSEAHARWVARNRFHHGLLGYTLQVNQSSRSEPQEYNVSIPHFWVPNAGAISFRVKSRSEVYPRKLSSWSEAWGLVCPPEVMPVKTALVTSVATVLGAGLVAAGLLLWWRKSLLYRLCPPIPRLRLPLAGEMVVWEPALEDCEVTPVTDA
uniprot
proteins
function
FUNCTION: Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells (By similarity). Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation (PubMed:10477686, PubMed:31990690). Activation of JAK2 leads to STAT5-mediated transcriptional program (PubMed:10376805). {ECO:0000250|UniProtKB:P26951, ECO:0000269|PubMed:10376805, ECO:0000269|PubMed:10477686, ECO:0000269|PubMed:31990690}.
uniprot
proteins
mass_dalton
43195
uniprot
proteins
mutagenesis
MUTAGEN 357; /note="K->R: Resistant to degradation."; /evidence="ECO:0000269|PubMed:31990690
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated at Lys-357 by RNFT2 in response to IL3. Ubiquitination leads ligand-induced degradation by the proteasome. Ubiquitinated by RNF128 via 'Lys-27'-linked polyubiquitination, facilitating its degradation through the lysosomal pathway (By similarity). {ECO:0000250|UniProtKB:P26951, ECO:0000269|PubMed:31990690}.
uniprot
proteins
protein_family
Type 5 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
10376805
uniprot
proteins
pubmed
10477686
uniprot
proteins
pubmed
1582416
uniprot
proteins
pubmed
19109256
uniprot
proteins
pubmed
31990690
uniprot
proteins
pubmed
7889941
uniprot
proteins
sequence_length
396
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Note=Expressed on the cell surface.; SUBCELLULAR LOCATION: [Isoform 2]: Endomembrane system; Single-pass type I membrane protein. Note=Mostly distributed inside the cells, except in the nuclei and is not transported to the cell surface.
uniprot
proteins
transmembrane_region
TRANSMEM 332..355; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins