RPL10L
entrez
140801
canonical
uniprot
Q96L21
canonical
ensembl
ENSG00000165496
resolver
ensp
ENSP00000298283
resolver
enst
ENST00000298283
resolver
genesymbol
RPL10L
resolver
hgnc
HGNC:17976
resolver
uniprot
Q8IUD1
resolver
uniprot_entry
RL10L_HUMAN
resolver
uniprot_sec
Q8IUD1
resolver
amino_acid_sequence
MGRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLGGHMVSDEYEQLSSEALEAARICANKYMVKSCGRDGFHMRVRLHPFHVIRINKMLSCAGADRLQTGMRGAFGKPQGTVARVHIGQVIMSIRTKLQNEEHVIEALRRAKFKFPGRQKIHISKKWGFTKFNADEFEDMVAKKCLIPDGCGVKYVPSHGPLDKWRVLHS
uniprot
proteins
disease_involvement
DISEASE: Spermatogenic failure 63 (SPGF63) [MIM:619689]: An autosomal recessive male infertility disorder characterized by severe oligozoospermia and reduced progressive sperm motility. {ECO:0000269|PubMed:32111475}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Testis-specific component of the ribosome, which is required for the transition from prophase to metaphase in male meiosis I (By similarity). Compensates for the inactivated X-linked RPL10 paralog during spermatogenesis (PubMed:12490704). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399, PubMed:25901680, PubMed:32669547). The male germ cell-specific ribosome displays a ribosomal polypeptide exit tunnel of distinct size and charge states compared with the classical ribosome (By similarity). It is responsible for regulating the biosynthesis and folding of a subset of male germ-cell-specific proteins that are essential for the formation of sperm (By similarity). {ECO:0000250|UniProtKB:P86048, ECO:0000269|PubMed:12490704, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:25901680, ECO:0000269|PubMed:32669547}.
uniprot
proteins
mass_dalton
24519
uniprot
proteins
protein_family
Universal ribosomal protein uL16 family
uniprot
proteins
pubmed
12490704
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19333399
uniprot
proteins
pubmed
23636399
uniprot
proteins
pubmed
25901680
uniprot
proteins
pubmed
28502657
uniprot
proteins
pubmed
32111475
uniprot
proteins
pubmed
32669547
uniprot
proteins
sequence_length
214
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:23636399, ECO:0000305|PubMed:25901680, ECO:0000305|PubMed:32669547}.
uniprot
proteins