ITPK1
entrez
3705
canonical
uniprot
Q13572
canonical
ensembl
ENSG00000100605
resolver
ensembl
ENSG00000274958
resolver
ensp
ENSP00000267615
resolver
ensp
ENSP00000346272
resolver
ensp
ENSP00000451091
resolver
ensp
ENSP00000451893
resolver
ensp
ENSP00000486579
resolver
enst
ENST00000555495
resolver
enst
ENST00000626917
resolver
genesymbol
ITPK1
resolver
hgnc
HGNC:6177
resolver
uniprot
G3V4M9
resolver
uniprot
Q9BTL6
resolver
uniprot
Q9H2E7
resolver
uniprot_entry
G3V4M9_HUMAN
resolver
uniprot_entry
ITPK1_HUMAN
resolver
uniprot_sec
Q9BTL6
resolver
uniprot_sec
Q9H2E7
resolver
amino_acid_sequence
MQTFLKGKRVGYWLSEKKIKKLNFQAFAELCRKRGMEVVQLNLSRPIEEQGPLDVIIHKLTDVILEADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSYELIRKIEAYMEDDRICSPPFMELTSLCGDDTMRLLEKNGLTFPFICKTRVAHGTNSHEMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLTELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIATVLQGQSTAMAATGDVALLRHSKLLAEPAGGLVGERTCSASPGCCGSMMGQDAPWKAEADAGGTAKLPHQRLGCNAGVSPSFQQHCVASLATKASSQ
uniprot
proteins
ec_number
2.7.1.134
uniprot
proteins
ec_number
2.7.1.159
uniprot
proteins
function
FUNCTION: Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3 (PubMed:11042108, PubMed:8662638). Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5 (PubMed:11042108). This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway (PubMed:11042108, PubMed:8662638). Also acts as an inositol polyphosphate phosphatase that dephosphorylates Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4 (PubMed:11909533, PubMed:17616525). May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium (PubMed:11909533). Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain (PubMed:11909533, PubMed:12925536, PubMed:17616525). Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:17616525). {ECO:0000269|PubMed:11042108, ECO:0000269|PubMed:11909533, ECO:0000269|PubMed:12925536, ECO:0000269|PubMed:17616525, ECO:0000269|PubMed:8662638}.
uniprot
proteins
mass_dalton
45621
uniprot
proteins
mutagenesis
MUTAGEN 18; /note="K->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:15837423"; MUTAGEN 58; /note="H->A: No effect."; /evidence="ECO:0000269|PubMed:15837423"; MUTAGEN 59; /note="K->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:15837423"; MUTAGEN 106; /note="R->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:15762844, ECO:0000269|PubMed:15837423"; MUTAGEN 157; /note="K->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:15762844"; MUTAGEN 162; /note="H->Q: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:15837423"; MUTAGEN 163; /note="G->A,P: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:15762844, ECO:0000269|PubMed:15837423"; MUTAGEN 163; /note="G->A: No effect."; /evidence="ECO:0000269|PubMed:15762844, ECO:0000269|PubMed:15837423"; MUTAGEN 167; /note="H->A,Q: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:15837423"; MUTAGEN 188; /note="Q->A: No effect."; /evidence="ECO:0000269|PubMed:15837423"; MUTAGEN 193; /note="H->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:15837423"; MUTAGEN 199; /note="K->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:15837423"; MUTAGEN 212; /note="R->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:15837423"; MUTAGEN 214; /note="S->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:15837423"; MUTAGEN 215; /note="L->A: No effect."; /evidence="ECO:0000269|PubMed:15837423"; MUTAGEN 281; /note="D->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:15762844"; MUTAGEN 295; /note="D->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:15762844"; MUTAGEN 297; /note="N->A,L: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:15762844, ECO:0000269|PubMed:15837423"; MUTAGEN 297; /note="N->D: Induces a strong reduction in kinase activity."; /evidence="ECO:0000269|PubMed:15762844, ECO:0000269|PubMed:15837423"; MUTAGEN 301; /note="G->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:15837423
uniprot
proteins
post_translational_modification
PTM: Acetylation by EP300 and CREBBP destabilizes ITPK1, and down-regulates enzymatic activity. Deacetylated by SIRT1. {ECO:0000269|PubMed:22308441}.
uniprot
proteins
protein_family
ITPK1 family
uniprot
proteins
pubmed
11042108
uniprot
proteins
pubmed
11533064
uniprot
proteins
pubmed
11909533
uniprot
proteins
pubmed
12324474
uniprot
proteins
pubmed
12925536
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15762844
uniprot
proteins
pubmed
15837423
uniprot
proteins
pubmed
17616525
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22308441
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
29883610
uniprot
proteins
pubmed
8662638
uniprot
proteins
sequence_length
414
uniprot
proteins