Tada2a
entrez
217031
canonical
uniprot
Q8CHV6
canonical
ensembl
ENSMUSG00000018651
resolver
ensp
ENSMUSP00000018795
resolver
ensp
ENSMUSP00000251476
resolver
ensp
ENSMUSP00000337430
resolver
enst
ENSMUST00000018795
resolver
genesymbol
Tada2a
resolver
genesymbol_syn
Tada2l
resolver
uniprot
Q3TZD7
resolver
uniprot
Q8BNK0
resolver
uniprot
Q8R3H5
resolver
uniprot_entry
TAD2A_MOUSE
resolver
uniprot_sec
Q3TZD7
resolver
uniprot_sec
Q8BNK0
resolver
uniprot_sec
Q8R3H5
resolver
amino_acid_sequence
MDRLGSFSNDPSDKPPCRGCSSYLTEPYIKCAECGPPPFFLCLQCFTRGFEYKKHQSDHTYEIMTSDFPVLDPSWTAQEEMALLEAVMDCGFGNWQDVANQMCTKTKEECEKHYMKHFINNPLFASTLLNLKQAEAAKAADTAIPFHSADDPPRPAFDSLLSRDMAGYMPARADFIEEFDNYAEWDLRDIDFVEDDSDILHALKMAVVDIYHSRLKERQRRKKIIRDHGLVNLRKFRLMERRYPKEVQDLYETMRRFARIVGPVEHDKFIESHALEFELRREIKRLQEYRTAGITNFCSARTYDHLKKTREEERLKRTMLSEVLQYIQDSSACQQWLRRQADIDSGLSPSVLMASNSGRRSAPPLNLTGLPGTEKLNEKEKELCQVVRLVPGAYLEYKSALLNECHKQGGLRLAQARALIKIDVNKTRKIYDFLIREGYITKA
uniprot
proteins
function
FUNCTION: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 (By similarity). Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-stranded DNA (PubMed:16299514). Binds dinucleosomes, probably at the linker region between neighboring nucleosomes (PubMed:16299514). Plays a role in chromatin remodeling (By similarity). May promote TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity (By similarity). May also promote XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage (By similarity). {ECO:0000250|UniProtKB:O75478, ECO:0000269|PubMed:16299514}.
uniprot
proteins
mass_dalton
51339
uniprot
proteins
mutagenesis
MUTAGEN 426; /note="K->A: Reduces DNA binding."; /evidence="ECO:0000269|PubMed:16299514"; MUTAGEN 428; /note="R->A: Loss of nuclear localization. Reduces DNA binding."; /evidence="ECO:0000269|PubMed:16299514"; MUTAGEN 429; /note="K->A: Reduces DNA binding."; /evidence="ECO:0000269|PubMed:16299514
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16299514
uniprot
proteins
pubmed
17428495
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
443
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00624, ECO:0000269|PubMed:16299514}. Chromosome {ECO:0000269|PubMed:16299514}.
uniprot
proteins