NLGN2
entrez
57555
canonical
uniprot
Q8NFZ4
canonical
ensembl
ENSG00000169992
resolver
ensembl
ENSG00000283859
resolver
ensp
ENSP00000305288
resolver
ensp
ENSP00000461168
resolver
ensp
ENSP00000492198
resolver
ensp
ENSP00000492323
resolver
enst
ENST00000302926
resolver
enst
ENST00000575301
resolver
enst
ENST00000639647
resolver
enst
ENST00000640620
resolver
genesymbol
NLGN2
resolver
genesymbol_syn
KIAA1366
resolver
hgnc
HGNC:14290
resolver
uniprot
Q9P2I1
resolver
uniprot_entry
NLGN2_HUMAN
resolver
uniprot_sec
Q9P2I1
resolver
amino_acid_sequence
MWLLALCLVGLAGAQRGGGGPGGGAPGGPGLGLGSLGEERFPVVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATLNPPDTDIRDPGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVATLNYRLGVLGFLSTGDQAAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIAQSGTAISSWSVNYQPLKYTRLLAAKVGCDREDSAEAVECLRRKPSRELVDQDVQPARYHIAFGPVVDGDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLKFVEDSAESEDGVSASAFDFTVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRDNGEMRRKTLLALFTDHQWVAPAVATAKLHADYQSPVYFYTFYHHCQAEGRPEWADAAHGDELPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVVWSKFNSKEKQYLHIGLKPRVRDNYRANKVAFWLELVPHLHNLHTELFTTTTRLPPYATRWPPRPPAGAPGTRRPPPPATLPPEPEPEPGPRAYDRFPGDSRDYSTELSVTVAVGASLLFLNILAFAALYYKRDRRQELRCRRLSPPGGSGSGVPGGGPLLPAAGRELPPEEELVSLQLKRGGGVGADPAEALRPACPPDYTLALRRAPDDVPLLAPGALTLLPSGLGPPPPPPPPSLHPFGPFPPPPPTATSHNNTLPHPHSTTRV
uniprot
proteins
function
FUNCTION: Transmembrane scaffolding protein involved in cell-cell interactions via its interactions with neurexin family members. Mediates cell-cell interactions both in neurons and in other types of cells, such as Langerhans beta cells. Plays a role in synapse function and synaptic signal transmission, especially via gamma-aminobutyric acid receptors (GABA(A) receptors). Functions by recruiting and clustering synaptic proteins. Promotes clustering of postsynaptic GABRG2 and GPHN. Promotes clustering of postsynaptic LHFPL4 (By similarity). Modulates signaling by inhibitory synapses, and thereby plays a role in controlling the ratio of signaling by excitatory and inhibitory synapses and information processing. Required for normal signal amplitude from inhibitory synapses, but is not essential for normal signal frequency. May promote the initial formation of synapses, but is not essential for this. In vitro, triggers the de novo formation of presynaptic structures. Mediates cell-cell interactions between Langerhans beta cells and modulates insulin secretion (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q69ZK9}.
uniprot
proteins
mass_dalton
90820
uniprot
proteins
post_translational_modification
PTM: N-glycosylated, contains high-mannose, hybrid, complex and sialylated N-glycans (PubMed:37865312). N-glycosylation is essential for localization to synapses, dendrites, and the cell membrane, and enhances its availability for trans-synaptic adhesion. O-glycosylated (By similarity). {ECO:0000250|UniProtKB:Q62888, ECO:0000269|PubMed:37865312}.
uniprot
proteins
protein_family
Type-B carboxylesterase/lipase family
uniprot
proteins
pubmed
10718198
uniprot
proteins
pubmed
12669065
uniprot
proteins
pubmed
18755801
uniprot
proteins
pubmed
19926856
uniprot
proteins
pubmed
23751499
uniprot
proteins
pubmed
37865312
uniprot
proteins
pubmed
9278515
uniprot
proteins
sequence_length
835
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:37865312}; Single-pass type I membrane protein {ECO:0000255}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q62888}; Single-pass type I membrane protein {ECO:0000255}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q62888}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q62888}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q62888}. Synapse {ECO:0000250|UniProtKB:Q62888}. Note=Detected at postsynaptic membranes in brain. Colocalizes with GPHN and ARHGEF9 at neuronal cell membranes (By similarity). Localized at presynaptic membranes in retina. Colocalizes with GABRG2 at inhibitory synapses in the retina. Localizes to dendritic membrane (By similarity). {ECO:0000250|UniProtKB:Q62888}.
uniprot
proteins
transmembrane_region
TRANSMEM 678..698; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins