HSPE1
entrez
3336
canonical
uniprot
P61604
canonical
ensembl
ENSG00000115541
resolver
ensp
ENSP00000233893
resolver
enst
ENST00000233893
resolver
genesymbol
HSPE1
resolver
hgnc
HGNC:5269
resolver
uniprot
A0A384N6A4
resolver
uniprot
O95421
resolver
uniprot
Q04984
resolver
uniprot
Q53X54
resolver
uniprot
Q9UDH0
resolver
uniprot_entry
A0A384N6A4_HUMAN
resolver
uniprot_entry
CH10_HUMAN
resolver
uniprot_sec
O95421
resolver
uniprot_sec
Q04984
resolver
uniprot_sec
Q53X54
resolver
uniprot_sec
Q9UDH0
resolver
amino_acid_sequence
MAGQAFRKFLPLFDRVLVERSAAETVTKGGIMLPEKSQGKVLQATVVAVGSGSKGKGGEIQPVSVKVGDKVLLPEYGGTKVVLDDKDYFLFRDGDILGKYVD
uniprot
proteins
function
FUNCTION: Co-chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp60, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix (PubMed:11422376, PubMed:1346131, PubMed:7912672). The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable). {ECO:0000269|PubMed:11422376, ECO:0000269|PubMed:1346131, ECO:0000269|PubMed:7912672, ECO:0000305|PubMed:25918392}.
uniprot
proteins
mass_dalton
10932
uniprot
proteins
protein_family
GroES chaperonin family
uniprot
proteins
pubmed
10763410
uniprot
proteins
pubmed
11422376
uniprot
proteins
pubmed
12483302
uniprot
proteins
pubmed
1346131
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21908771
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25918392
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
7912672
uniprot
proteins
pubmed
7914093
uniprot
proteins
pubmed
7916212
uniprot
proteins
sequence_length
102
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix.
uniprot
proteins