Iqub
entrez
214704
canonical
uniprot
Q8CDK3
canonical
ensembl
ENSMUSG00000046192
resolver
ensp
ENSMUSP00000051177
resolver
enst
ENSMUST00000052277
resolver
genesymbol
Iqub
resolver
uniprot
B2RQH8
resolver
uniprot
Q3TT98
resolver
uniprot_entry
IQUB_MOUSE
resolver
uniprot_sec
B2RQH8
resolver
uniprot_sec
Q3TT98
resolver
amino_acid_sequence
MSDPEEERVADSTAHYEEAGKVISIPRPSDEAEGSDVMPEQDDEVQELTTESEENVERHSEFSLSTPKSDDSKPREEVTSLGSASGSQDQDYRLLDYQKGEDDELLFLHKIKAIKETLQTSVRESIATVKIVLIPAGQEIIMPFRVDAPFRFLKEHFAHLLHIPHYVLQITHEGIIVGNNESLIQYGIKPQEIVQVEVFSTLPDQYPVRRIEGLSEGSQIITVTIQTSIDRYEEVAVEIIKSDFHKPFLGGFRHKITGLEYHNAGTQTVPRKIPEKDNLFCRDTQTVFQKKKLQQTTNTTSTQMTKIGVYVSNMTDKLLKPGNYFSAAEYHARRLHAVIVIQTSYRRWHAKRYVESLRKQKKLRLEWEEEQELLKIQEKEEWIRMDYYRRHNPKTTEDFELLYNALELWRQEEVEQICHYSSEAERKAALCELLEKETQMIASIGRHRSAARMERQDAAIQAFLDKCSAPNVWRRGDGKTIEMDTQFTIRARELQSIYKCILLKDLSQDERLDILLTLKHTVKEHECKLTQEILELIDREVDLMMRGVKPHNLEGLRKRITTLFIHYIKTPLFNPEVAKYLKVPQDPLKFYDTIYFCHSCQNYLPSVEFSVSPTSHRVYRCRHCINLENETQRRESFLKYKCLLQRLYYSEADYGDNSQIAFLMQLQDIKYLTENIWASQSALSAWDDLNDLVMVRWDKHVEWSPWNCILLTKDESTAHLRLPSIEKGYGHHFVHKIKHKHILAKNYFSQIPTLASLILNDDEVEDIRSKHSTKSPPKIIITRRIQPH
uniprot
proteins
function
FUNCTION: Anchors the radial spoke 1 (RS1) complex to the A microtubule of outer doublet microtubules in axonemes (PubMed:36355624, PubMed:36417862). The triple radial spokes (RS1, RS2 and RS3) are required to modulate beating of the sperm flagellum (PubMed:36355624, PubMed:36417862). May play a role in inhibiting signaling via MAPK1/ERK2 and MAPK3/ERK1 (PubMed:36355624). Additionally, may play a role in the functioning of cilia (PubMed:21289087). Not required for the functioning of tracheal or ependymal cilia (PubMed:36417862). {ECO:0000269|PubMed:21289087, ECO:0000269|PubMed:36355624, ECO:0000269|PubMed:36417862}.
uniprot
proteins
mass_dalton
92130
uniprot
proteins
mutagenesis
MUTAGEN 310..788; /note="Missing: Male infertility due to asthenospermia; leads to radial spoke defects, and increased levels of phosphorylated MAPK1/ERK2 and MAPK3/ERK1."; /evidence="ECO:0000269|PubMed:36355624
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21289087
uniprot
proteins
pubmed
36355624
uniprot
proteins
pubmed
36417862
uniprot
proteins
sequence_length
788
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:36417862}. Cell projection, cilium {ECO:0000269|PubMed:36417862}. Note=Localizes to the axoneme of sperm cells and the cilia of tracheal epithelial cells. {ECO:0000269|PubMed:36417862}.
uniprot
proteins