SECISBP2
entrez
79048
canonical
uniprot
Q96T21
canonical
ensembl
ENSG00000187742
resolver
ensp
ENSP00000364959
resolver
ensp
ENSP00000364965
resolver
ensp
ENSP00000436650
resolver
ensp
ENSP00000529017
resolver
ensp
ENSP00000529018
resolver
ensp
ENSP00000529019
resolver
ensp
ENSP00000606058
resolver
ensp
ENSP00000606061
resolver
ensp
ENSP00000630380
resolver
ensp
ENSP00000630382
resolver
ensp
ENSP00000792006
resolver
genesymbol
SECISBP2
resolver
genesymbol_syn
SBP2
resolver
hgnc
HGNC:30972
resolver
uniprot
A0A1S5UZH3
resolver
uniprot
B4DR97
resolver
uniprot
B4DZC7
resolver
uniprot
F8W892
resolver
uniprot
Q5HYY1
resolver
uniprot
Q7L1Z0
resolver
uniprot
Q8IYC0
resolver
uniprot
Q9H0A1
resolver
uniprot
Q9H948
resolver
uniprot_entry
A0A1S5UZH3_HUMAN
resolver
uniprot_entry
B4DR97_HUMAN
resolver
uniprot_entry
B4DZC7_HUMAN
resolver
uniprot_entry
Q9H948_HUMAN
resolver
uniprot_entry
SEBP2_HUMAN
resolver
uniprot_sec
F8W892
resolver
uniprot_sec
Q5HYY1
resolver
uniprot_sec
Q7L1Z0
resolver
uniprot_sec
Q8IYC0
resolver
uniprot_sec
Q9H0A1
resolver
amino_acid_sequence
MASEGPREPESEGIKLSADVKPFVPRFAGLNVAWLESSEACVFPSSAATYYPFVQEPPVTEQKIYTEDMAFGASTFPPQYLSSEITLHPYAYSPYTLDSTQNVYSVPGSQYLYNQPSCYRGFQTVKHRNENTCPLPQEMKALFKKKTYDEKKTYDQQKFDSERADGTISSEIKSARGSHHLSIYAENSLKSDGYHKRTDRKSRIIAKNVSTSKPEFEFTTLDFPELQGAENNMSEIQKQPKWGPVHSVSTDISLLREVVKPAAVLSKGEIVVKNNPNESVTANAATNSPSCTRELSWTPMGYVVRQTLSTELSAAPKNVTSMINLKTIASSADPKNVSIPSSEALSSDPSYNKEKHIIHPTQKSKASQGSDLEQNEASRKNKKKKEKSTSKYEVLTVQEPPRIEDAEEFPNLAVASERRDRIETPKFQSKQQPQDNFKNNVKKSQLPVQLDLGGMLTALEKKQHSQHAKQSSKPVVVSVGAVPVLSKECASGERGRRMSQMKTPHNPLDSSAPLMKKGKQREIPKAKKPTSLKKIILKERQERKQRLQENAVSPAFTSDDTQDGESGGDDQFPEQAELSGPEGMDELISTPSVEDKSEEPPGTELQRDTEASHLAPNHTTFPKIHSRRFRDYCSQMLSKEVDACVTDLLKELVRFQDRMYQKDPVKAKTKRRLVLGLREVLKHLKLKKLKCVIISPNCEKIQSKGGLDDTLHTIIDYACEQNIPFVFALNRKALGRSLNKAVPVSVVGIFSYDGAQDQFHKMVELTVAARQAYKTMLENVQQELVGEPRPQAPPSLPTQGPSCPAEDGPPALKEKEEPHYIEIWKKHLEAYSGCTLELEESLEASTSQMMNLNL
uniprot
proteins
disease_involvement
DISEASE: Thyroid hormone metabolism, abnormal, 1 (THMA1) [MIM:609698]: A disorder associated with a reduction in type II iodothyronine deiodinase activity. {ECO:0000269|PubMed:16228000, ECO:0000269|PubMed:29882503}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: mRNA-binding protein that binds to the SECIS (selenocysteine insertion sequence) element present in the 3'-UTR of mRNAs encoding selenoproteins and facilitates the incorporation of the rare amino acid selenocysteine (PubMed:35709277). Insertion of selenocysteine at UGA codons is mediated by SECISBP2 and EEFSEC: SECISBP2 (1) specifically binds the SECIS sequence once the 80S ribosome encounters an in-frame UGA codon and (2) contacts the RPS27A/eS31 of the 40S ribosome before ribosome stalling (PubMed:35709277). (3) GTP-bound EEFSEC then delivers selenocysteinyl-tRNA(Sec) to the 80S ribosome and adopts a preaccommodated state conformation (PubMed:35709277). (4) After GTP hydrolysis, EEFSEC dissociates from the assembly, selenocysteinyl-tRNA(Sec) accommodates, and peptide bond synthesis and selenoprotein elongation occur (PubMed:35709277). {ECO:0000269|PubMed:35709277}.
uniprot
proteins
mass_dalton
95462
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12095701
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16228000
uniprot
proteins
pubmed
19004874
uniprot
proteins
pubmed
29882503
uniprot
proteins
pubmed
35709277
uniprot
proteins
sequence_length
854
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion {ECO:0000269|PubMed:19004874}.
uniprot
proteins