Dsg4
entrez
16769
canonical
uniprot
Q7TMD7
canonical
ensembl
ENSMUSG00000001804
resolver
ensp
ENSMUSP00000019426
resolver
enst
ENSMUST00000019426
resolver
genesymbol
Dsg4
resolver
uniprot_entry
DSG4_MOUSE
resolver
amino_acid_sequence
MDWLLFRNICLLILFMVVLGVNSEFIVEVKELDIENGTTTWQTVRRQKREWIKFAAACREGEDNSKRNPIARIRSDCEVSQRITYRISGAGIDRPPYGVFTINPRTGEINITSVVDREITPLFLIHCRALNSRGEDLERPLELRVKVMDVNDNPPVFTQNVYTANIEENSDANALVVKLSATDADEDNHLNSKIAYKIISQEPAGAPMFMVNRYTGEVRTMSNFLDREQHSMYNLLVRGSDRDGATDGLSSECDCRIKILDVNDNFPILEKTSYSASIEENCLSSELIRLQAIDLDEEGTDNWLAQYSILSGNDGNWFEIQTDPKTNEGILKVVKMLDYEQEPNIYLSIGVRNQAEFHHSVASQFQMHSTPVRIQVVNVREGPTFSPSSMTFSLRGGMRGASLMNYVLGTYTAIDMDTGNPATNVRYVIGHDAGSWLKVDSRTGEIQFSREFDMKSKYITDGIYAAQILAIDDGSGRTATGTICIEIPDANDYCPVIYAESRSVCTHASSVRIYVNDHSFGSPFTFCVVDESPDIANIWDIRSINGTSAILMTEQTLSPGPYQIPILVKDSHNRACELPQTVLLDACFCDDHHVCLHSSTTGIYTGDITWVTDDMYGTVTDDGVRQSNVGLGPAGIGMIILGLLLLLLSPLLLLMCCCKRRQPEGLGTRFAPVPEGGEGVMQPWRIEGAHPEDRDVSNICVPMTASNTQDRIDSSEIYTNTYAGGGTVEGGVSGVELNTGVGTATGMVAAGATGTLRKRSSTIGTLREYQDTGMNMAFLDSYFSEKAYAYADEDEGRPANDCLLIYDHEGAGSPVGSIGCCSWIVDDLDESYIETLDPKFRTLAEICLDTEIEPFPSHQACIPISTDLPLLGPNYFVNESSGMTLSEAEFQAEMAAASEPMIHGDIIVTETYTTSDPCVQPTTIVFDSQIPPNVVVTETVMAPVYDVQGNICVPAEIANTHNVYYAERVVASPGIPDMGNSNISDACIGPVMSGGILVGPEIQVTQMMSPDIHISQTTGSTSPMTSQHRVTRYSNMHYSRQ
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Dsg4 are the cause of an autosomal recessive phenotype lanceolate hair (lah) (PubMed:12705872). Lah mouse pups develop only a few short hairs on the head and neck which form a lance head at the tip and disappear within a few month (PubMed:12705872). They have thickened skin and do not exhibit any growth retardation (PubMed:12705872). {ECO:0000269|PubMed:12705872}.
uniprot
proteins
function
FUNCTION: A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:12705872). Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (PubMed:12705872). Plays a role in moderating lymphocyte migration to inflamed skin and maintaining homeostasis of the epidermal inflammatory response (By similarity). {ECO:0000250|UniProtKB:Q6W3B0, ECO:0000269|PubMed:12705872}.
uniprot
proteins
mass_dalton
114449
uniprot
proteins
pubmed
12705872
uniprot
proteins
pubmed
12787123
uniprot
proteins
sequence_length
1041
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q86SJ6}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, desmosome {ECO:0000250|UniProtKB:Q86SJ6}. Note=Colocalizes with JUP at desmosomes. {ECO:0000250|UniProtKB:Q86SJ6}.
uniprot
proteins
transmembrane_region
TRANSMEM 635..655; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins