Slfn2
entrez
20556
canonical
uniprot
Q9Z0I6
canonical
ensembl
ENSMUSG00000072620
resolver
ensp
ENSMUSP00000035562
resolver
enst
ENSMUST00000038038
resolver
genesymbol
Slfn2
resolver
uniprot_entry
SLFN2_MOUSE
resolver
amino_acid_sequence
MGTRLEATEQSNHRTQRNDIQLENAKAAGKMGISVDLEAKYAKLGLNLGAITFGEKDRKKMKNSHLRKQENANISLAVCALLNSGGGAIKVKIENENYSLTRDGLGLDLEASLCKCLPFVQWHLDFTESEGYIYIYVKSWSQEIFGLPIGTLRTNLYVRSMSSSVQVSAAAALEFLQDLEETGGRPCVRPELPASIAFPEVEGEWHLEDLAAALFNRTEFQYEETFPFTRSRYVEVTLLSAKRLRKRIKELLPQTVSAFANTDGGFLFIGLDGKTQQIIGFEAEKSDLVLLESEIEKHIRQLPVTHFCEEKEKIKYTCKFIEVHKSGAVCAYVCALRVERFCCAVFAAEPESWHVEGGCVKRFTTEEWVKLQMNAPSG
uniprot
proteins
function
FUNCTION: tRNA-binding protein involved in T-cell mediated immunity (PubMed:33986151). Plays a key role during the metabolic reprograming phase of activated T-cell, when T-cells produce reactive oxygen species (ROS): acts by binding tRNAs and protecting them from cleavage by the oxidative stress-activated ribonuclease angiogenin (ANG) (PubMed:33986151). Also required for T-cell quiescence maintenance (PubMed:20190759). {ECO:0000269|PubMed:20190759, ECO:0000269|PubMed:33986151}.
uniprot
proteins
mass_dalton
42438
uniprot
proteins
mutagenesis
MUTAGEN 67..68; /note="RK->AA: Abolished tRNA-binding."; /evidence="ECO:0000269|PubMed:33986151"; MUTAGEN 242..249; /note="KRLRKRIK->ARLRKRIA: Abolished tRNA-binding."; /evidence="ECO:0000269|PubMed:33986151"; MUTAGEN 278; /note="I->N: In elektra mutation; impaired T-cell quiescence. Mice show elevated susceptibility to bacterial and viral infections and to diminished numbers of T-cells that fail to proliferate in response to infection and diverse proliferative stimuli. T-cells display chronic endoplasmic reticulum (ER) stress under steady state conditions. T-cells also show elevated de novo sterol synthesis."; /evidence="ECO:0000269|PubMed:20190759, ECO:0000269|PubMed:27276683, ECO:0000269|PubMed:28672048
uniprot
proteins
protein_family
Schlafen family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19592487
uniprot
proteins
pubmed
20190759
uniprot
proteins
pubmed
27276683
uniprot
proteins
pubmed
28672048
uniprot
proteins
pubmed
30275530
uniprot
proteins
pubmed
33986151
uniprot
proteins
pubmed
9846487
uniprot
proteins
sequence_length
378
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19592487}.
uniprot
proteins