RPS19BP1
entrez
91582
canonical
uniprot
Q86WX3
canonical
ensembl
ENSG00000187051
resolver
ensp
ENSP00000333948
resolver
enst
ENST00000334678
resolver
genesymbol
RPS19BP1
resolver
genesymbol_syn
AROS
resolver
hgnc
HGNC:28749
resolver
uniprot
B0QY96
resolver
uniprot
Q5JZA1
resolver
uniprot_entry
AROS_HUMAN
resolver
uniprot_sec
B0QY96
resolver
uniprot_sec
Q5JZA1
resolver
amino_acid_sequence
MSAALLRRGLELLAASEAPRDPPGQAKPRGAPVKRPRKTKAIQAQKLRNSAKGKVPKSALDEYRKRECRDHLRVNLKFLTRTRSTVAESVSQQILRQNRGRKACDRPVAKTKKKKAEGTVFTEEDFQKFQQEYFGS
uniprot
proteins
function
FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Acts as a chaperone that specifically mediates the integration of RPS19 in state post-A1 (PubMed:34516797). Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity (PubMed:17964266). {ECO:0000269|PubMed:17964266, ECO:0000269|PubMed:34516797}.
uniprot
proteins
mass_dalton
15434
uniprot
proteins
post_translational_modification
PTM: Citrullinated by PADI4. {ECO:0000250}.
uniprot
proteins
protein_family
AROS family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17964266
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
34516797
uniprot
proteins
sequence_length
136
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:17964266, ECO:0000269|PubMed:34516797}.
uniprot
proteins