Folr1
entrez
14275
canonical
uniprot
P35846
canonical
ensembl
ENSMUSG00000001827
resolver
ensp
ENSMUSP00000102594
resolver
ensp
ENSMUSP00000102595
resolver
ensp
ENSMUSP00000102596
resolver
ensp
ENSMUSP00000102598
resolver
ensp
ENSMUSP00000102599
resolver
ensp
ENSMUSP00000199958
resolver
ensp
ENSMUSP00000329245
resolver
ensp
ENSMUSP00000329246
resolver
ensp
ENSMUSP00000329249
resolver
ensp
ENSMUSP00000329253
resolver
ensp
ENSMUSP00000329256
resolver
ensp
ENSMUSP00000348542
resolver
ensp
ENSMUSP00000365290
resolver
enst
ENSMUST00000106981
resolver
enst
ENSMUST00000106982
resolver
enst
ENSMUST00000106983
resolver
enst
ENSMUST00000106985
resolver
enst
ENSMUST00000106986
resolver
genesymbol
Folr1
resolver
genesymbol_syn
Fbp1
resolver
genesymbol_syn
Folbp1
resolver
uniprot
Q9R222
resolver
uniprot_entry
FOLR1_MOUSE
resolver
uniprot_sec
Q9R222
resolver
amino_acid_sequence
MAHLMTVQLLLLVMWMAECAQSRATRARTELLNVCMDAKHHKEKPGPEDNLHDQCSPWKTNSCCSTNTSQEAHKDISYLYRFNWNHCGTMTSECKRHFIQDTCLYECSPNLGPWIQQVDQSWRKERILDVPLCKEDCQQWWEDCQSSFTCKSNWHKGWNWSSGHNECPVGASCHPFTFYFPTSAALCEEIWSHSYKLSNYSRGSGRCIQMWFDPAQGNPNEEVARFYAEAMSGAGFHGTWPLLCSLSLVLLWVIS
uniprot
proteins
function
FUNCTION: Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells (PubMed:1894617). Has high affinity for folate and folic acid analogs at neutral pH (By similarity). Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release (By similarity). Required for normal embryonic development and normal cell proliferation (PubMed:10508523, PubMed:12854656, PubMed:15259034, PubMed:17286298). Required for renal folate reabsorption (PubMed:15703271). {ECO:0000250|UniProtKB:P15328, ECO:0000269|PubMed:10508523, ECO:0000269|PubMed:12854656, ECO:0000269|PubMed:15259034, ECO:0000269|PubMed:15703271, ECO:0000269|PubMed:17286298, ECO:0000269|PubMed:1894617}.
uniprot
proteins
mass_dalton
29449
uniprot
proteins
post_translational_modification
PTM: The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. {ECO:0000250|UniProtKB:P15328}.
uniprot
proteins
protein_family
Folate receptor family
uniprot
proteins
pubmed
10216260
uniprot
proteins
pubmed
10508523
uniprot
proteins
pubmed
12854656
uniprot
proteins
pubmed
1429588
uniprot
proteins
pubmed
15259034
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15703271
uniprot
proteins
pubmed
17286298
uniprot
proteins
pubmed
1894617
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
255
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P15328}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P15328}. Apical cell membrane {ECO:0000250|UniProtKB:P15328}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P15328}. Basolateral cell membrane {ECO:0000250|UniProtKB:P15328}; Lipid-anchor, GPI-like-anchor {ECO:0000250|UniProtKB:P15328}. Secreted {ECO:0000250|UniProtKB:P15328}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:P15328}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:P15328}. Endosome {ECO:0000250|UniProtKB:P15328}. Note=Endocytosed into cytoplasmic vesicles and then recycled to the cell membrane. {ECO:0000250|UniProtKB:P15328}.
uniprot
proteins