Eci2
entrez
291075
canonical
uniprot
Q5XIC0
canonical
ensembl
ENSRNOG00000066714
resolver
ensp
ENSRNOP00000022022
resolver
enst
ENSRNOT00000022022
resolver
genesymbol
Eci2
resolver
genesymbol_syn
Peci
resolver
uniprot
A0A8L2QBE2
resolver
uniprot_entry
A0A8L2QBE2_RAT
resolver
uniprot_entry
ECI2_RAT
resolver
amino_acid_sequence
MAAVTWSRARCWCPSLLQVLRLPVTKLHLGRPAMRATQQDFENAMNQVKLLKKDPGNEVKLRLYALYKQATEGPCTMPKPGVFDFVNKAKWDAWNALGSLPKETARQNYVDLVSSLSSSSEASSQGKGGADGKAQESKGILVTSEGGITKITFNRPSKKNAITFQMYQDIILALKNASTDDTVITVFTGAGDYYSSGNDLTNFTSASGGMEEAANKGAIVLREFVNTFIDFPKPLVAVVNGPAVGISVTLLGLFDAVYASDRATFHTPFSHLGQSPEACSSYTFPKMMGSAKAAEMLLFGKKLTAREAWAQGLVTEVFPESTFETEVWTRLKTYAKLPPNSMRISKELIRKNEKEKLHAVNEEECTTLRARWLSEECINAIMSFVTRKPKL
uniprot
proteins
ec_number
5.3.3.8
uniprot
proteins
function
FUNCTION: Auxiliary enzyme in the beta-oxidation of mono- and polyunsaturated fatty acids. Together with the 2,4-dienoyl-CoA reductase (DECR) and the Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase (ECH), they allow the reentrance of the enoyl-CoA into the beta-oxidation cycle (PubMed:11781327). Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of fatty enoyl-CoA species, with a preference for (3E)-enoyl-CoAs over (3Z)-enoyl-CoAs (PubMed:11781327). Based on its established catalytic mechanism, it is predicted to act also on other fatty acids besides those tested experimentally (Probable). {ECO:0000269|PubMed:11781327, ECO:0000305|PubMed:11781327}.
uniprot
proteins
mass_dalton
43021
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid beta-oxidation. {ECO:0000269|PubMed:11781327}.
uniprot
proteins
protein_family
Enoyl-CoA hydratase/isomerase family
uniprot
proteins
pubmed
11781327
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
391
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome matrix {ECO:0000269|PubMed:11781327}. Mitochondrion {ECO:0000269|PubMed:11781327}.
uniprot
proteins