SPSB1
entrez
80176
canonical
uniprot
Q96BD6
canonical
ensembl
ENSG00000171621
resolver
ensp
ENSP00000330221
resolver
ensp
ENSP00000350573
resolver
ensp
ENSP00000366616
resolver
ensp
ENSP00000522433
resolver
ensp
ENSP00000522434
resolver
ensp
ENSP00000522435
resolver
ensp
ENSP00000522436
resolver
ensp
ENSP00000522437
resolver
ensp
ENSP00000616722
resolver
ensp
ENSP00000616723
resolver
enst
ENST00000328089
resolver
enst
ENST00000357898
resolver
enst
ENST00000377399
resolver
enst
ENST00000852374
resolver
enst
ENST00000852375
resolver
enst
ENST00000852376
resolver
enst
ENST00000852377
resolver
enst
ENST00000852378
resolver
enst
ENST00000946663
resolver
enst
ENST00000946664
resolver
genesymbol
SPSB1
resolver
genesymbol_syn
SSB1
resolver
hgnc
HGNC:30628
resolver
uniprot
A2A275
resolver
uniprot
Q59FA1
resolver
uniprot
Q5TIH9
resolver
uniprot
Q9BRY9
resolver
uniprot
Q9H6C5
resolver
uniprot_entry
SPSB1_HUMAN
resolver
uniprot_sec
A2A275
resolver
uniprot_sec
Q59FA1
resolver
uniprot_sec
Q5TIH9
resolver
uniprot_sec
Q9BRY9
resolver
uniprot_sec
Q9H6C5
resolver
amino_acid_sequence
MGQKVTGGIKTVDMRDPTYRPLKQELQGLDYCKPTRLDLLLDMPPVSYDVQLLHSWNNNDRSLNVFVKEDDKLIFHRHPVAQSTDAIRGKVGYTRGLHVWQITWAMRQRGTHAVVGVATADAPLHSVGYTTLVGNNHESWGWDLGRNRLYHDGKNQPSKTYPAFLEPDETFIVPDSFLVALDMDDGTLSFIVDGQYMGVAFRGLKGKKLYPVVSAVWGHCEIRMRYLNGLDPEPLPLMDLCRRSVRLALGRERLGEIHTLPLPASLKAYLLYQ
uniprot
proteins
function
FUNCTION: Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199876). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876). {ECO:0000269|PubMed:15601820, ECO:0000269|PubMed:21199876}.
uniprot
proteins
mass_dalton
30942
uniprot
proteins
mutagenesis
MUTAGEN 31; /note="Y->F: Loss of phosphorylation."; /evidence="ECO:0000269|PubMed:15713673"; MUTAGEN 260..263; /note="LPLP->AAAA: Abolishes interaction with RNF7 and CUL5."; /evidence="ECO:0000269|PubMed:15601820
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
SPSB family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15601820
uniprot
proteins
pubmed
15713673
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17189197
uniprot
proteins
pubmed
20561531
uniprot
proteins
pubmed
21199876
uniprot
proteins
pubmed
28931592
uniprot
proteins
sequence_length
273
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Cytoplasm, cytosol {ECO:0000269|PubMed:21199876}. Note=Exhibits a diffuse cytosolic localization. {ECO:0000269|PubMed:21199876}.
uniprot
proteins