Htr2b
entrez
29581
canonical
uniprot
P30994
canonical
ensembl
ENSRNOG00000017625
resolver
ensembl
ENSRNOG00065020494
resolver
ensp
ENSRNOP00000023829
resolver
ensp
ENSRNOP00065027794
resolver
enst
ENSRNOT00000023829
resolver
enst
ENSRNOT00065034649
resolver
genesymbol
Htr2b
resolver
genesymbol_syn
Srl
resolver
uniprot
G3V8A0
resolver
uniprot
Q9QW44
resolver
uniprot_entry
5HT2B_RAT
resolver
uniprot_entry
G3V8A0_RAT
resolver
uniprot_sec
Q9QW44
resolver
amino_acid_sequence
MASSYKMSEQSTISEHILQKTCDHLILTDRSGLKAESAAEEMKQTAENQGNTVHWAALLIFAVIIPTIGGNILVILAVSLEKRLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEATWPLPLALCPAWLFLDVLFSTASIMHLCAISLDRYIAIKKPIQANQCNSRTTAFVKITVVWLISIGIAIPVPIKGIEADVVNAHNITCELTKDRFGSFMLFGSLAAFFAPLTIMIVTYFLTIHALRKKAYLVRNRPPQRLTRWTVSTVLQREDSSFSSPEKMVMLDGSHKDKILPNSTDETLMRRMSSAGKKPAQTISNEQRASKVLGIVFLFFLLMWCPFFITNVTLALCDSCNQTTLKTLLQIFVWVGYVSSGVNPLIYTLFNKTFREAFGRYITCNYQATKSVKVLRKCSSTLYFGNSMVENSKFFTKHGIRNGINPAMYQSPVRLRSSTIQSSSIILLNTFLTENDGDKVEDQVSYI
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1331748, PubMed:1505525). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PubMed:22525520). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:1331748, PubMed:1505525). HTR2B is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively (By similarity). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (By similarity). Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity (By similarity). May play a role in the perception of pain (PubMed:22525520). Plays a role in the regulation of behavior, including impulsive behavior (By similarity). Required for normal proliferation of embryonic cardiac myocytes and normal heart development (By similarity). Protects cardiomyocytes against apoptosis (By similarity). Plays a role in the adaptation of pulmonary arteries to chronic hypoxia (By similarity). Plays a role in vasoconstriction (By similarity). Required for normal osteoblast function and proliferation, and for maintaining normal bone density (By similarity). Required for normal proliferation of the interstitial cells of Cajal in the intestine (By similarity). {ECO:0000250|UniProtKB:P41595, ECO:0000250|UniProtKB:Q02152, ECO:0000269|PubMed:1331748, ECO:0000269|PubMed:1505525, ECO:0000269|PubMed:22525520}.
uniprot
proteins
mass_dalton
53652
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
1331748
uniprot
proteins
pubmed
1505525
uniprot
proteins
pubmed
22525520
uniprot
proteins
sequence_length
479
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1331748, ECO:0000269|PubMed:1505525, ECO:0000269|PubMed:22525520}; Multi-pass membrane protein {ECO:0000269|PubMed:1505525}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q02152}.
uniprot
proteins
transmembrane_region
TRANSMEM 56..78; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P41595"; TRANSMEM 90..112; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P41595"; TRANSMEM 129..150; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P41595"; TRANSMEM 171..191; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P41595"; TRANSMEM 216..238; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P41595"; TRANSMEM 324..344; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P41595"; TRANSMEM 360..381; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P41595
uniprot
proteins