Ifnb1
entrez
24481
canonical
uniprot
P70499
canonical
ensembl
ENSRNOG00000006268
resolver
ensembl
ENSRNOG00055017348
resolver
ensembl
ENSRNOG00060014167
resolver
ensembl
ENSRNOG00065019667
resolver
ensp
ENSRNOP00000008225
resolver
ensp
ENSRNOP00055023605
resolver
ensp
ENSRNOP00060019338
resolver
ensp
ENSRNOP00065026499
resolver
enst
ENSRNOT00000008224
resolver
enst
ENSRNOT00055029363
resolver
enst
ENSRNOT00060024229
resolver
enst
ENSRNOT00065033134
resolver
genesymbol
Ifnb1
resolver
genesymbol_syn
Ifnb
resolver
uniprot_entry
IFNB_RAT
resolver
amino_acid_sequence
MANRWTLHIAFLLCFSTTALSIDYKQLQFRQSTSIRTCQKLLRQLNGRLNLSYRTDFKIPMEVMHPSQMEKSYTAFAIQVMLQNVFLVFRSNFSSTGWNETIVESLLDELHQQTELLEIILKEKQEERLTWVTSTTTLGLKSYYWRVQRYLKDKKYNSYAWMVVRAEVFRNFSIILRLNRNFQN
uniprot
proteins
function
FUNCTION: Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli. Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins (By similarity). Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways. Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor. Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss. IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth (By similarity). {ECO:0000250|UniProtKB:P01574, ECO:0000250|UniProtKB:P01575}.
uniprot
proteins
mass_dalton
22073
uniprot
proteins
post_translational_modification
PTM: This beta interferon does not have a disulfide bond.
uniprot
proteins
protein_family
Type-I (or alpha/beta) interferon family
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
9126338
uniprot
proteins
sequence_length
184
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01574}.
uniprot
proteins