RUFY1
entrez
80230
canonical
uniprot
Q96T51
canonical
ensembl
ENSG00000176783
resolver
ensembl
ENSG00000284260
resolver
ensp
ENSP00000325594
resolver
ensp
ENSP00000377087
resolver
ensp
ENSP00000390025
resolver
ensp
ENSP00000624323
resolver
ensp
ENSP00000672685
resolver
genesymbol
RUFY1
resolver
genesymbol_syn
RABIP4
resolver
genesymbol_syn
ZFYVE12
resolver
hgnc
HGNC:19760
resolver
uniprot
A8K7B1
resolver
uniprot
Q59FF3
resolver
uniprot
Q71S93
resolver
uniprot
Q9H6I3
resolver
uniprot_entry
A8K7B1_HUMAN
resolver
uniprot_entry
RUFY1_HUMAN
resolver
uniprot_sec
Q59FF3
resolver
uniprot_sec
Q71S93
resolver
uniprot_sec
Q9H6I3
resolver
amino_acid_sequence
MADREGGCAAGRGRELEPELEPGPGPGSALEPGEEFEIVDRSQLPGPGDLRSATRPRAAEGWSAPILTLARRATGNLSASCGSALRAAAGLGGGDSGDGTARAASKCQMMEERANLMHMMKLSIKVLLQSALSLGRSLDADHAPLQQFFVVMEHCLKHGLKVKKSFIGQNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLIDNKHLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLYLKDVQDLDGGKEHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQEEQQQLREQNELIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKAQNAESSLQQKNEAITSFEGKTNQVMSSMKQMEERLQHSERARQGAEERSHKLQQELGGRIGALQLQLSQLHEQCSSLEKELKSEKEQRQALQRELQHEKDTSSLLRMELQQVEGLKKELRELQDEKAELQKICEEQEQALQEMGLHLSQSKLKMEDIKEVNQALKGHAWLKDDEATHCRQCEKEFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCSSTAS
uniprot
proteins
function
FUNCTION: Activating adapter involved in cargo sorting from early/recycling endosomes. Regulates retrieval of proteins from endosomes to the trans-Golgi network through interaction with the dynein-dynactin complex (PubMed:36282215). Dual effector of RAB4B and RAB14, mediates a cooperative interaction allowing endosomal tethering and fusion (PubMed:20534812). Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking (PubMed:14617813). In oocytes, self-assembles to form a protein matrix which hold together endolysosomes, autophagosomes and proteasomes and generate non-membrane-bound compartments called endo-lysosomal vesicular assemblies (ELVAs). In immature oocytes, ELVAs sequester ubiquitinated protein aggregates and degrade them upon oocyte maturation (By similarity). {ECO:0000250|UniProtKB:Q8BIJ7, ECO:0000269|PubMed:14617813, ECO:0000269|PubMed:20534812, ECO:0000269|PubMed:36282215}.
uniprot
proteins
mass_dalton
79818
uniprot
proteins
mutagenesis
MUTAGEN 389; /note="Y->F: Abolishes phosphorylation and endosomal targeting; when associated with F-400."; /evidence="ECO:0000269|PubMed:11877430"; MUTAGEN 400; /note="Y->F: Abolishes phosphorylation and endosomal targeting; when associated with F-389."; /evidence="ECO:0000269|PubMed:11877430
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Tyr-389 and/or Tyr-400 is required for interaction with BMX and endosomal targeting. {ECO:0000269|PubMed:11877430}.
uniprot
proteins
pubmed
11877430
uniprot
proteins
pubmed
14617813
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
19296456
uniprot
proteins
pubmed
20534812
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
36282215
uniprot
proteins
sequence_length
708
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:20534812, ECO:0000269|PubMed:36282215}; Peripheral membrane protein {ECO:0000269|PubMed:20534812}. Note=In oocytes, localizes in non-membrane-bound compartments called endo-lysosomal vesicular assemblies (ELVAs). {ECO:0000250|UniProtKB:Q8BIJ7}.
uniprot
proteins