FGL1
entrez
2267
canonical
uniprot
Q08830
canonical
ensembl
ENSG00000104760
resolver
ensp
ENSP00000371262
resolver
ensp
ENSP00000371263
resolver
ensp
ENSP00000381131
resolver
ensp
ENSP00000381133
resolver
ensp
ENSP00000401952
resolver
ensp
ENSP00000428430
resolver
ensp
ENSP00000429757
resolver
ensp
ENSP00000574526
resolver
ensp
ENSP00000574527
resolver
ensp
ENSP00000574528
resolver
ensp
ENSP00000574529
resolver
ensp
ENSP00000574531
resolver
ensp
ENSP00000574532
resolver
ensp
ENSP00000574536
resolver
ensp
ENSP00000574537
resolver
ensp
ENSP00000574538
resolver
ensp
ENSP00000574540
resolver
ensp
ENSP00000574541
resolver
ensp
ENSP00000574543
resolver
ensp
ENSP00000574545
resolver
ensp
ENSP00000574546
resolver
ensp
ENSP00000574550
resolver
ensp
ENSP00000574551
resolver
ensp
ENSP00000574555
resolver
ensp
ENSP00000574556
resolver
ensp
ENSP00000574557
resolver
ensp
ENSP00000574558
resolver
ensp
ENSP00000574561
resolver
ensp
ENSP00000574562
resolver
ensp
ENSP00000574564
resolver
ensp
ENSP00000574565
resolver
ensp
ENSP00000636685
resolver
enst
ENST00000381840
resolver
enst
ENST00000381841
resolver
enst
ENST00000398054
resolver
enst
ENST00000398056
resolver
enst
ENST00000427924
resolver
enst
ENST00000518650
resolver
enst
ENST00000522444
resolver
enst
ENST00000904467
resolver
enst
ENST00000904468
resolver
enst
ENST00000904469
resolver
enst
ENST00000904470
resolver
enst
ENST00000904472
resolver
enst
ENST00000904473
resolver
enst
ENST00000904477
resolver
enst
ENST00000904478
resolver
enst
ENST00000904479
resolver
enst
ENST00000904481
resolver
enst
ENST00000904482
resolver
enst
ENST00000904484
resolver
enst
ENST00000904486
resolver
enst
ENST00000904487
resolver
enst
ENST00000904491
resolver
enst
ENST00000904492
resolver
enst
ENST00000904496
resolver
enst
ENST00000904497
resolver
enst
ENST00000904498
resolver
enst
ENST00000904499
resolver
enst
ENST00000904502
resolver
enst
ENST00000904503
resolver
enst
ENST00000904505
resolver
enst
ENST00000904506
resolver
enst
ENST00000966626
resolver
genesymbol
FGL1
resolver
genesymbol_syn
HFREP1
resolver
hgnc
HGNC:3695
resolver
uniprot
A6NKU4
resolver
uniprot
Q4PJH9
resolver
uniprot
Q53YF1
resolver
uniprot
Q8NG32
resolver
uniprot
Q96KW6
resolver
uniprot
Q96QM6
resolver
uniprot_entry
FGL1_HUMAN
resolver
uniprot_sec
A6NKU4
resolver
uniprot_sec
Q4PJH9
resolver
uniprot_sec
Q53YF1
resolver
uniprot_sec
Q8NG32
resolver
uniprot_sec
Q96KW6
resolver
uniprot_sec
Q96QM6
resolver
amino_acid_sequence
MAKVFSFILVTTALTMGREISALEDCAQEQMRLRAQVRLLETRVKQQQVKIKQLLQENEVQFLDKGDENTVIDLGSKRQYADCSEIFNDGYKLSGFYKIKPLQSPAEFSVYCDMSDGGGWTVIQRRSDGSENFNRGWKDYENGFGNFVQKHGEYWLGNKNLHFLTTQEDYTLKIDLADFEKNSRYAQYKNFKVGDEKNFYELNIGEYSGTAGDSLAGNFHPEVQWWASHQRMKFSTWDRDHDNYEGNCAEEDQSGWWFNRCHSANLNGVYYSGPYTAKTDNGIVWYTWHGWWYSLKSVVMKIRPNDFIPNVI
uniprot
proteins
function
FUNCTION: Immune suppressive molecule that inhibits antigen-specific T-cell activation by acting as a ligand of LAG3 (PubMed:30580966, PubMed:35761082, PubMed:40101708). LAG3-binding initiates a signaling that inhibits the T-cell receptor (TCR) in the immunological synapse, preventing T-cell activation (PubMed:30580966). Binds LAG3 independently from MHC class II (MHC-II) (PubMed:30580966, PubMed:35761082). Secreted by, and promotes growth of, hepatocytes (PubMed:11470158, PubMed:19880967). {ECO:0000269|PubMed:11470158, ECO:0000269|PubMed:19880967, ECO:0000269|PubMed:30580966, ECO:0000269|PubMed:35761082, ECO:0000269|PubMed:40101708}.
uniprot
proteins
mass_dalton
36379
uniprot
proteins
mutagenesis
MUTAGEN 136; /note="G->E: Increased binding to LAG3; when associated with I-181 and E-220."; /evidence="ECO:0000269|PubMed:35761082"; MUTAGEN 181; /note="K->I: Increased binding to LAG3; when associated with E-136 and E-220."; /evidence="ECO:0000269|PubMed:35761082"; MUTAGEN 290; /note="G->E: Increased binding to LAG3. Increased binding to LAG3; when associated with E-136 and I-181."; /evidence="ECO:0000269|PubMed:35761082
uniprot
proteins
pubmed
11470158
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
18039467
uniprot
proteins
pubmed
19880967
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
30580966
uniprot
proteins
pubmed
35761082
uniprot
proteins
pubmed
40101708
uniprot
proteins
pubmed
8390249
uniprot
proteins
sequence_length
312
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11470158, ECO:0000269|PubMed:30580966}. Note=Secreted in the blood plasma. {ECO:0000269|PubMed:30580966}.
uniprot
proteins