PYM1
entrez
84305
canonical
uniprot
Q9BRP8
canonical
ensembl
ENSG00000170473
resolver
ensp
ENSP00000381271
resolver
ensp
ENSP00000386156
resolver
genesymbol
PYM1
resolver
genesymbol_syn
PYM
resolver
genesymbol_syn
WIBG
resolver
hgnc
HGNC:30258
resolver
uniprot
B6ZDM5
resolver
uniprot
Q8IXJ8
resolver
uniprot
Q8N8E7
resolver
uniprot_entry
PYM1_HUMAN
resolver
uniprot_sec
B6ZDM5
resolver
uniprot_sec
Q8IXJ8
resolver
uniprot_sec
Q8N8E7
resolver
amino_acid_sequence
MEAAGSPAATETGKYIASTQRPDGTWRKQRRVKEGYVPQEEVPVYENKYVKFFKSKPELPPGLSPEATAPVTPSRPEGGEPGLSKTAKRNLKRKEKRRQQQEKGEAEALSRTLDKVSLEETAQLPSAPQGSRAAPTAASDQPDSAATTEKAKKIKNLKKKLRQVEELQQRIQAGEVSQPSKEQLEKLARRRALEEELEDLELGL
uniprot
proteins
function
FUNCTION: Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC. {ECO:0000269|PubMed:18026120, ECO:0000269|PubMed:19410547}.
uniprot
proteins
mass_dalton
22656
uniprot
proteins
protein_family
Pym family
uniprot
proteins
pubmed
12438415
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14968132
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
18026120
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19410547
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
204
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14968132, ECO:0000269|PubMed:18026120}. Nucleus, nucleolus {ECO:0000269|PubMed:14968132}. Nucleus, nucleoplasm {ECO:0000269|PubMed:14968132}. Note=Shuttles between the nucleus and the cytoplasm (PubMed:14968132). Nuclear export is mediated by XPO1/CRM1 (PubMed:14968132). {ECO:0000269|PubMed:14968132}.
uniprot
proteins