Cdh5
entrez
12562
canonical
uniprot
P55284
canonical
ensembl
ENSMUSG00000031871
resolver
ensp
ENSMUSP00000034339
resolver
ensp
ENSMUSP00000317978
resolver
enst
ENSMUST00000034339
resolver
genesymbol
Cdh5
resolver
uniprot
O35542
resolver
uniprot_entry
CADH5_MOUSE
resolver
uniprot_sec
O35542
resolver
amino_acid_sequence
MQRLTELATALGAFLGLLAVAAMAGPNFPQIDTPNMLPAHHRQKRDWIWNQMHIDEEKNESLPHYVGKIKSNVNRQNAKYVLQGEFAGKIFGVDANTGNVLAYERLDREKVSEYFLTALIVDKNTNKNLEQPSSFTVKVHDINDNWPVFSHQVFNASVPEMSAIGTSVIRVTAVDADDPTVAGHATVLYQIVKGNEYFSIDNSGLIFTKIKNLDREKQAEYKIVVETQDALGLRGESGTATVMIRLEDINDNFPVFTQSTYTFSVPEDIRVGKPLGFLTVVDPDEPQNRMTKYSIMQGEYRDTFTIETDPKRNEGIIKPTKSLDYEVIQQYTFYIEATDPTIRYEYLSSTSGKNKAMVTINVLDVDEPPVFQRHFYHFKLPENQKKPLIGTVVAKDPDKAQRSIGYSIRKTSDRGQFFRITKQGNIYNEKELDRETYAWYNLTVEANELDSRGNPVGKESIVQVYIEVLDENDNPPEFAQPYEPKVCENAAQGKLVVQISATDKDVVPVNPKFKFALKNEDSNFTLINNHDNTANITVKYGQFNREHAKFHYLPVLISDNGVPSLTGTSTLTVGVCKCNEQGEFTFCEEMAAQAGVSIQALVAIFLCILTITVITLLIILRRRIRKQAHAHSKSALEIHEQLVTYDEEGGGEMDTTSYDVSVLNSVRGGSTKPLRSTMDARPAVYTQVQKPPRLAPGLHGGPREMATMIDVKKEEADNDGGGPPYDTLHIYGYEGAESIAESLSSLSTNSSDSDIDYDFLNDWGPRFKMLAELYGSDPQEELII
uniprot
proteins
function
FUNCTION: Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity). This cadherin may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (PubMed:20332120, PubMed:9220534). It associates with alpha-catenin forming a link to the cytoskeleton (By similarity). Plays a role in coupling actin fibers to cell junctions in endothelial cells, via acting as a cell junctional complex anchor for AMOTL2 and MAGI1 (PubMed:24806444). Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen (PubMed:27466317). These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B (By similarity). Positively regulates reorientation of actin stress fibers and endothelial cell reorientation in response to cellular mechantransduction (By similarity). Required for activation of PRKCZ and for localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction (By similarity). Associates with CTNND1/p120-catenin to control CADH5 endocytosis (PubMed:33972531). {ECO:0000250|UniProtKB:P33151, ECO:0000250|UniProtKB:Q8AYD0, ECO:0000269|PubMed:20332120, ECO:0000269|PubMed:24806444, ECO:0000269|PubMed:27466317, ECO:0000269|PubMed:33972531, ECO:0000269|PubMed:9220534}.
uniprot
proteins
mass_dalton
87903
uniprot
proteins
mutagenesis
MUTAGEN 621..623; /note="RRR->AAA: Abolishes interaction with PALS1."; /evidence="ECO:0000269|PubMed:27466317"; MUTAGEN 624..626; /note="IRK->AAA: Abolishes interaction with PALS1."; /evidence="ECO:0000269|PubMed:27466317"; MUTAGEN 774; /note="Y->A: No effect on PARD3 binding."; /evidence="ECO:0000269|PubMed:20047332"; MUTAGEN 777; /note="D->A: Impairs PARD3 binding."; /evidence="ECO:0000269|PubMed:20047332
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB. {ECO:0000269|PubMed:12234928}.; PTM: O-glycosylated. {ECO:0000250}.
uniprot
proteins
pubmed
12234928
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19635461
uniprot
proteins
pubmed
20047332
uniprot
proteins
pubmed
20332120
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22492353
uniprot
proteins
pubmed
24806444
uniprot
proteins
pubmed
27466317
uniprot
proteins
pubmed
28179430
uniprot
proteins
pubmed
33972531
uniprot
proteins
pubmed
8555485
uniprot
proteins
pubmed
9220534
uniprot
proteins
sequence_length
784
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000269|PubMed:19635461, ECO:0000269|PubMed:24806444, ECO:0000269|PubMed:33972531}. Cell membrane {ECO:0000269|PubMed:19635461}; Single-pass type I membrane protein {ECO:0000269|PubMed:19635461}. Cytoplasm {ECO:0000269|PubMed:24806444}. Note=Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions (By similarity). {ECO:0000250|UniProtKB:P33151}.
uniprot
proteins
transmembrane_region
TRANSMEM 600..620; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins