CHST11
entrez
50515
canonical
uniprot
Q9NPF2
canonical
ensembl
ENSG00000171310
resolver
ensp
ENSP00000305725
resolver
ensp
ENSP00000450004
resolver
genesymbol
CHST11
resolver
hgnc
HGNC:17422
resolver
uniprot
A8K4F8
resolver
uniprot
Q9NXY6
resolver
uniprot
Q9NY36
resolver
uniprot_entry
CHSTB_HUMAN
resolver
uniprot_sec
A8K4F8
resolver
uniprot_sec
Q9NXY6
resolver
uniprot_sec
Q9NY36
resolver
amino_acid_sequence
MKPALLEVMRMNRICRMVLATCLGSFILVIFYFQSMLHPVMRRNPFGVDICCRKGSRSPLQELYNPIQLELSNTAVLHQMRRDQVTDTCRANSATSRKRRVLTPNDLKHLVVDEDHELIYCYVPKVACTNWKRLMMVLTGRGKYSDPMEIPANEAHVSANLKTLNQYSIPEINHRLKSYMKFLFVREPFERLVSAYRNKFTQKYNISFHKRYGTKIIKRQRKNATQEALRKGDDVKFEEFVAYLIDPHTQREEPFNEHWQTVYSLCHPCHIHYDLVGKYETLEEDSNYVLQLAGVGSYLKFPTYAKSTRTTDEMTTEFFQNISSEHQTQLYEVYKLDFLMFNYSVPSYLKLE
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving CHST11 is found in B-cell chronic lymphocytic leukemias. Translocation t(12;14)(q23;q32) with IgH. {ECO:0000269|PubMed:15273723}.; DISEASE: Osteochondrodysplasia, brachydactyly, and overlapping malformed digits (OCBMD) [MIM:618167]: An autosomal recessive disorder characterized by bilateral symmetric skeletal defects that primarily affect the limbs. Affected individuals have mild short stature due to shortening of the lower leg bones, as well as hand and foot malformations, predominantly brachydactyly and overlapping digits. Other skeletal defects include scoliosis, dislocated patellae and fibulae, and pectus excavatum. {ECO:0000269|PubMed:29514872}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.8.2.5
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6-di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor.
uniprot
proteins
mass_dalton
41555
uniprot
proteins
mutagenesis
MUTAGEN 125; /note="K->Q: Abolishes enzyme activity but does not affect stability of the protein."; /evidence="ECO:0000269|PubMed:15628971"; MUTAGEN 205; /note="N->S: Induces a weak decrease in enzyme activity but has no effect on stability of the protein. Unstable protein; when associated with S-223 and S-321."; /evidence="ECO:0000269|PubMed:15628971"; MUTAGEN 223; /note="N->S: Induces a weak decrease in enzyme activity but has no effect on stability of the protein. Unstable protein; when associated with S-205 and S-321."; /evidence="ECO:0000269|PubMed:15628971"; MUTAGEN 321; /note="N->S: Induces a strong decrease in enzyme activity but has no effect on stability of the protein. Unstable protein; when associated with S-205 and S-223."; MUTAGEN 342; /note="N->S: Induces a strong decrease in enzyme activity has no effect on stability of the protein."; /evidence="ECO:0000269|PubMed:15628971
uniprot
proteins
post_translational_modification
PTM: N-glycosylated; required for activity and stability. {ECO:0000269|PubMed:15628971}.
uniprot
proteins
protein_family
Sulfotransferase 2 family
uniprot
proteins
pubmed
10781601
uniprot
proteins
pubmed
11056388
uniprot
proteins
pubmed
12847091
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15273723
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15628971
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
29514872
uniprot
proteins
sequence_length
352
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 17..37; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins