Amotl1
entrez
75723
canonical
uniprot
Q9D4H4
canonical
ensembl
ENSMUSG00000013076
resolver
ensp
ENSMUSP00000013220
resolver
ensp
ENSMUSP00000152834
resolver
ensp
ENSMUSP00000221687
resolver
enst
ENSMUST00000223132
resolver
genesymbol
Amotl1
resolver
uniprot
A0A1Y7VM69
resolver
uniprot
B9EKN5
resolver
uniprot
Q571F1
resolver
uniprot_entry
A0A1Y7VM69_MOUSE
resolver
uniprot_entry
AMOL1_MOUSE
resolver
uniprot_sec
B9EKN5
resolver
uniprot_sec
Q571F1
resolver
amino_acid_sequence
MRRAKSRRGPCEPVLRAPPPICYSPSSPVQILEDPAYFYPDLQLYSGRHEASTLTVEASGGLRGKSVEDPLSSFHSPNFLRTPEVEMRGSEDVASGRVLQRLIQEQLRYGTPTENMNLLAIQHQATGSAGPAHATTNFSSTETLTQEDPQMVYQSARQEPQGQEHQGDNTVMEKQVRSTQPQQNNEELPTYEEAKAQSQFFRGQQQQQQQQQQQQQQQQQQGQGPLSHTYYMAGGTSQKSRTEGRPTVNRANSGQAHKDEALKELKQGHVRSLSERIMQLSLERNGAKQHLPSSGNGKSFKAGGEPSPAQPVCKALDPRGPPPEYPFKTKPMKSPVSKNQDHGLYYNDQHPGVLHEMVKPYPAPQPARTEVAVLRYQPPPEYGVTSRPCQLPFPSTVQQHSPMSSQTSSIGGTLHSVSLPLPLPISLAASQPLPASPNQQLGPDAFAIVERAQQMVEILTEENRVLHQELQGCYDNADKLHKFEKELQSISEAYESLVKSTTKRESLDKAMRTKLEGEIRRLHDFNRDLRDRLETANRQLSSREYDGHEDKAAESHYVSQNKEFLKEKEKLEMELAAVRTASEDHRRHIEILDQALSNAQARVIKLEEELREKQAYVEKVEKLQQALTQLQSACEKRGQMERRLRTWLERELDALRTQQKHGTGPPVSLPECNAPALMELVREKEERILALEADMTKWEQKYLEESTIRHFAMSAAAAATAERDTTISNHSRNGSYGESSLEAHIWPEEEEVVQANRRCQDMEYTIKNLHAKIIEKDAMIKVLQQRSRKDAGKTDSASLRPARSVPSIAAATGTHSRQTSLTSSQLTEEKKEEKTTWKGSIGFLLGKEHQGQASAPLLPTTPASALSLPASTTSASSTHAKTGSKDSSTQTDKSTELFWPSMASLPSRGRLSTAPSNSPILKHPAAKGAVEKQENSPGHGKASEHRGRVSNLLHKPEFPDGEMMEVLI
uniprot
proteins
function
FUNCTION: Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. {ECO:0000250}.
uniprot
proteins
mass_dalton
107950
uniprot
proteins
mutagenesis
MUTAGEN 157; /note="R->C: Heterozygotes do not survive in Mendelian ratios at weaning."; /evidence="ECO:0000269|PubMed:30375152
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated by NEDD4, leading to proteasomal degradation. {ECO:0000250}.
uniprot
proteins
protein_family
Angiomotin family
uniprot
proteins
pubmed
11733531
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30375152
uniprot
proteins
sequence_length
968
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000269|PubMed:11733531}.
uniprot
proteins