Habp2
entrez
292126
canonical
uniprot
Q6L711
canonical
ensembl
ENSRNOG00000016659
resolver
ensembl
ENSRNOG00055029775
resolver
ensembl
ENSRNOG00060018993
resolver
ensembl
ENSRNOG00065011192
resolver
ensp
ENSRNOP00000022382
resolver
ensp
ENSRNOP00055042569
resolver
ensp
ENSRNOP00060026926
resolver
ensp
ENSRNOP00065013802
resolver
enst
ENSRNOT00055051628
resolver
enst
ENSRNOT00060032929
resolver
enst
ENSRNOT00065018118
resolver
genesymbol
Habp2
resolver
uniprot
A2VD04
resolver
uniprot_entry
A2VD04_RAT
resolver
uniprot_entry
HABP2_RAT
resolver
amino_acid_sequence
MSVVMLVFRVLLLIALVGNSAIGLSLMPFIAPPDPDWTPDDYYYSYEQSSPDKDASVTQTSPENPDWYYEDDDPCQSNPCEHGGDCIIRGNTFSCSCPAPFSGSRCQTVQNKCKDNPCVQGDCLITQTPPYYRCACKYPYTGPDCSKVLPVCRPNPCQNGGVCSRHRRRSRFSCACPDQYKGRFCEIGPDDCYVGDGYSYRGKVSRTVNQNPCLYWNSHLLLQENYNMFMEDAETHGIADHNFCRNPDGDHKPWCFVKVNSEKVKWEYCNVEVCPESDAANPVGSLQEPVMELPGFDSCGKTEMTEHAVKRIYGGFKSTAGKHPWQVSLQTSLPLTTSMPQGHFCGGSLIHPCWVLTAAHCTDMSTKHLKVVLGDQDLKKTESHEQTFRVEKILKYSQYNERDEIPHNDIALLKLKPVGGHCALESKYVKTVCLPSDPFPSGTECHISGWGVTETGEGSRQLLDAKVKLIANALCNSRQLYDHTIDDSMICAGNLQKPGSDTCQGDSGGPLTCEKDGTYYVYGIVSWGQECGKKPGVYTQVTKFLNWIKTTMHKEAGL
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form. Activates coagulation factor VII. May function as a tumor suppressor negatively regulating cell proliferation and cell migration. {ECO:0000250|UniProtKB:Q14520}.
uniprot
proteins
mass_dalton
62093
uniprot
proteins
post_translational_modification
PTM: Proteolytic cleavage at Gly-23 or Met-27 can give rise to the 50 kDa heavy chain (HC) and cleavage at Arg-311 or Lys-317 can give rise to the 27 kDa light chain (LC). The HC can undergo further proteolytic cleavage giving rise to a 26 kDa fragment. The LC can undergo further proteolytic cleavage at Arg-311 leading to a 17-kDa fragment and at Arg-478 leading to a 8-kDa fragment. {ECO:0000250|UniProtKB:Q14520}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
sequence_length
558
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q14520}. Note=Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form. {ECO:0000250|UniProtKB:Q14520}.
uniprot
proteins