Clybl
entrez
69634
canonical
uniprot
Q8R4N0
canonical
ensembl
ENSMUSG00000025545
resolver
ensp
ENSMUSP00000026625
resolver
enst
ENSMUST00000026625
resolver
genesymbol
Clybl
resolver
genesymbol_syn
Clb
resolver
uniprot
Q9D7D0
resolver
uniprot_entry
CLYBL_MOUSE
resolver
uniprot_sec
Q9D7D0
resolver
amino_acid_sequence
MALCVLRNTVRGAAALPRLKASHVVSVYKPRYSSLSNHKYVPRRAVLYVPGNDEKKIRKIPSLKVDCAVLDCEDGVAENKKNEARLRIAKTLEDFDLGTTEKCVRINSVSSGLAEVDLETFLQARVLPSSLMLPKVEGPEEIRWFSDKFSLHLKGRKLEQPMNLIPFVETAMGLLNFKAVCEETLKTGPQVGLCLDAVVFGGEDFRASIGATSNKDTQDILYARQKVVVTAKAFGLQAIDLVYIDFRDEDGLLRQSREAAAMGFTGKQVIHPNQIAVVQEQFTPTPEKIQWAEELIAAFKEHQQLGKGAFTFRGSMIDMPLLKQAQNIVTLATSIKEK
uniprot
proteins
ec_number
2.3.3.-
uniprot
proteins
ec_number
2.3.3.9
uniprot
proteins
ec_number
3.1.2.30
uniprot
proteins
ec_number
4.1.3.25
uniprot
proteins
function
FUNCTION: Mitochondrial enzyme required to detoxify vitamin B12-poisoning metabolites (PubMed:29056341). Acts as a citramalyl-CoA lyase by converting citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway, a pathway required to detoxify itaconate, a vitamin B12-poisoning metabolite (By similarity). Also acts as a malyl-CoA thioesterase to detoxify malyl-CoA, a side product of citric acid cycle enzymes, which is toxic for the vitamin B12-dependent enzyme MMUT (By similarity). Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate (By similarity). Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate (By similarity). Also has very weak citramalate synthase activity in vitro (By similarity). {ECO:0000250|UniProtKB:Q8N0X4, ECO:0000269|PubMed:29056341}.
uniprot
proteins
mass_dalton
37549
uniprot
proteins
protein_family
Citrate lyase beta subunit-like subfamily
uniprot
proteins
protein_family
HpcH/HpaI aldolase family
uniprot
proteins
pubmed
11741334
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18614015
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
24334609
uniprot
proteins
pubmed
29056341
uniprot
proteins
sequence_length
338
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:18614015}.
uniprot
proteins