EXD2
entrez
55218
canonical
uniprot
Q9NVH0
canonical
ensembl
ENSG00000081177
resolver
ensp
ENSP00000313140
resolver
ensp
ENSP00000386762
resolver
ensp
ENSP00000386839
resolver
ensp
ENSP00000386915
resolver
ensp
ENSP00000387331
resolver
ensp
ENSP00000510642
resolver
ensp
ENSP00000574222
resolver
genesymbol
EXD2
resolver
genesymbol_syn
C14orf114
resolver
genesymbol_syn
EXDL2
resolver
hgnc
HGNC:20217
resolver
uniprot
A8K948
resolver
uniprot
B4DIH6
resolver
uniprot
G5E947
resolver
uniprot
Q6AWB6
resolver
uniprot
Q86TX3
resolver
uniprot
Q8N3D3
resolver
uniprot_entry
A8K948_HUMAN
resolver
uniprot_entry
EXD2_HUMAN
resolver
uniprot_entry
Q86TX3_HUMAN
resolver
uniprot_sec
B4DIH6
resolver
uniprot_sec
G5E947
resolver
uniprot_sec
Q6AWB6
resolver
uniprot_sec
Q8N3D3
resolver
amino_acid_sequence
MSRQNLVALTVTTLLGVAVGGFVLWKGIQRRRRSKTSPVTQQPQQKVLGSRELPPPEDDQLHSSAPRSSWKERILKAKVVTVSQEAEWDQIEPLLRSELEDFPVLGIDCEWVNLEGKASPLSLLQMASPSGLCVLVRLPKLICGGKTLPRTLLDILADGTILKVGVGCSEDASKLLQDYGLVVRGCLDLRYLAMRQRNNLLCNGLSLKSLAETVLNFPLDKSLLLRCSNWDAETLTEDQVIYAARDAQISVALFLHLLGYPFSRNSPGEKNDDHSSWRKVLEKCQGVVDIPFRSKGMSRLGEEVNGEATESQQKPRNKKSKMDGMVPGNHQGRDPRKHKRKPLGVGYSARKSPLYDNCFLHAPDGQPLCTCDRRKAQWYLDKGIGELVSEEPFVVKLRFEPAGRPESPGDYYLMVKENLCVVCGKRDSYIRKNVIPHEYRKHFPIEMKDHNSHDVLLLCTSCHAISNYYDNHLKQQLAKEFQAPIGSEEGLRLLEDPERRQVRSGARALLNAESLPTQRKEELLQALREFYNTDVVTEEMLQEAASLETRISNENYVPHGLKVVQCHSQGGLRSLMQLESRWRQHFLDSMQPKHLPQQWSVDHNHQKLLRKFGEDLPIQLS
uniprot
proteins
ec_number
3.1.11.1
uniprot
proteins
ec_number
3.1.13.-
uniprot
proteins
function
FUNCTION: Exonuclease that has both 3'-5' exoribonuclease and exodeoxyribonuclease activities, depending on the divalent metal cation used as cofactor (PubMed:29335528, PubMed:31127291). In presence of Mg(2+), only shows 3'-5' exoribonuclease activity, while it shows both exoribonuclease and exodeoxyribonuclease activities in presence of Mn(2+) (PubMed:29335528, PubMed:31127291). Acts as an exoribonuclease in mitochondrion, possibly by regulating ATP production and mitochondrial translation (PubMed:29335528). Also involved in the response to DNA damage (PubMed:26807646, PubMed:31255466). Acts as 3'-5' exodeoxyribonuclease for double-strand breaks resection and efficient homologous recombination (PubMed:20603073, PubMed:26807646). Plays a key role in controlling the initial steps of chromosomal break repair, it is recruited to chromatin in a damage-dependent manner and functionally interacts with the MRN complex to accelerate resection through its 3'-5' exonuclease activity, which efficiently processes double-stranded DNA substrates containing nicks (PubMed:26807646). Also involved in response to replicative stress: recruited to stalled forks and is required to stabilize and restart stalled replication forks by restraining excessive fork regression, thereby suppressing their degradation (PubMed:31255466). {ECO:0000269|PubMed:20603073, ECO:0000269|PubMed:26807646, ECO:0000269|PubMed:29335528, ECO:0000269|PubMed:31127291, ECO:0000269|PubMed:31255466}.
uniprot
proteins
mass_dalton
70353
uniprot
proteins
mutagenesis
MUTAGEN 108..110; /note="DCE->ACA: Loss of 3'-5' exonuclease activity. Impaired ability to stabilize and restart stalled replication forks in response to replication stress."; /evidence="ECO:0000269|PubMed:26807646, ECO:0000269|PubMed:31255466"; MUTAGEN 190; /note="R->A: Abolished exodeoxyribonuclease activity."; /evidence="ECO:0000269|PubMed:31127291"; MUTAGEN 195; /note="R->A: Impaired exonuclease activity."; /evidence="ECO:0000269|PubMed:31127291"; MUTAGEN 197; /note="R->A: Impaired exonuclease activity."; /evidence="ECO:0000269|PubMed:31127291"; MUTAGEN 221; /note="K->A: Impaired exonuclease activity."; /evidence="ECO:0000269|PubMed:31127291"; MUTAGEN 226; /note="R->A: Abolished exonuclease activity."; /evidence="ECO:0000269|PubMed:31127291
uniprot
proteins
protein_family
EXD2 family
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
20603073
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
26807646
uniprot
proteins
pubmed
29335528
uniprot
proteins
pubmed
29599527
uniprot
proteins
pubmed
31127291
uniprot
proteins
pubmed
31255466
uniprot
proteins
sequence_length
621
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:29599527, ECO:0000269|PubMed:31127291}; Single-pass membrane protein {ECO:0000255, ECO:0000269|PubMed:31127291}. Mitochondrion matrix {ECO:0000269|PubMed:29335528}. Nucleus {ECO:0000269|PubMed:26807646}. Chromosome {ECO:0000269|PubMed:26807646, ECO:0000269|PubMed:31255466}. Note=Mainly localizes to the mitochondrial outer membrane (PubMed:29599527, PubMed:31127291). May translocate to the nucleus in response to DNA damage; however mechanism that explain nuclear localization are unknown and require experimental evidence (PubMed:26807646). Recruited to replication forks following replication stress (PubMed:31255466). {ECO:0000269|PubMed:26807646, ECO:0000269|PubMed:29599527, ECO:0000269|PubMed:31127291, ECO:0000269|PubMed:31255466}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..25; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins