Arhgap24
entrez
231532
canonical
uniprot
Q8C4V1
canonical
ensembl
ENSMUSG00000057315
resolver
ensp
ENSMUSP00000070048
resolver
ensp
ENSMUSP00000073028
resolver
ensp
ENSMUSP00000092138
resolver
ensp
ENSMUSP00000108473
resolver
ensp
ENSMUSP00000108474
resolver
ensp
ENSMUSP00000228892
resolver
enst
ENSMUST00000070000
resolver
enst
ENSMUST00000094559
resolver
genesymbol
Arhgap24
resolver
uniprot
D3Z5T4
resolver
uniprot
G3X9N1
resolver
uniprot
Q8BHH3
resolver
uniprot
Q8CA50
resolver
uniprot
Q8QZZ0
resolver
uniprot_entry
D3Z5T4_MOUSE
resolver
uniprot_entry
G3X9N1_MOUSE
resolver
uniprot_entry
Q8BHH3_MOUSE
resolver
uniprot_entry
RHG24_MOUSE
resolver
uniprot_sec
Q8CA50
resolver
uniprot_sec
Q8QZZ0
resolver
amino_acid_sequence
MEERCESTESPQGQGRKNTKCGWLRKQGGFVKTWHTRWFVLKGDQLYYFKDEDETKPLGTIFLHGNKVIEHPCNEENPGKFLFDVVPGGERDRMTANHESYLLMASTQNDMEDWVKSIRRVIWGPFGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVVPYAKYEDFLSCATLLSKEEEAGVKELMKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSAQNLATVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMISKHDRLFPKDTEPQSKPQDGPNSNNNDGHKKATMGQLQNKENNNTKESPVRRCSWDKPESPQRSSVDNGSPTALSGSKTNSPRNSIHKLDISRSPPLMVKKNPAFNKGSGIVTNGSFSSSNAEGVEKPQTTPNGSLQARRTSSLKSSGTKMGTHSVQNGTVRMGILNTDTLGNSLNGRSMSWLPNGYVTLRDNKQKEPAGESGQHNRLSTYDNVHQQFSSMSLDDKHSVDSATWSTSSCEISLPENSNSCRSSTTTCPEQDFYVGNFEDPVLDGPPQDDLSHPGDYENKSDRRSVGGRSSRATSSSDNSETFVGNTSSNHSALHSLVSSLKQEMTKQKIEYESRIKSLEQRNLTLETEMLSLHDELDQERKKFTMIEIKMRNAERAKEDAEKRNDMLQKEMEQFFSTFGDLTVEPRRSERGNTIWIQ
uniprot
proteins
function
FUNCTION: Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
84100
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by ROCK, leading to activate the RacGAP activity. {ECO:0000250}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
747
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction, adherens junction {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Cell projection {ECO:0000250}. Note=Localizes to actin stress fibers. In migrating cells, localizes to membrane lamellae and protusions (By similarity). {ECO:0000250}.
uniprot
proteins