Mtrf1
entrez
211253
canonical
uniprot
Q8K126
canonical
ensembl
ENSMUSG00000022022
resolver
ensp
ENSMUSP00000022600
resolver
ensp
ENSMUSP00000264091
resolver
ensp
ENSMUSP00000264093
resolver
enst
ENSMUST00000022600
resolver
genesymbol
Mtrf1
resolver
uniprot_entry
RF1M_MOUSE
resolver
amino_acid_sequence
MSHHLCIWLFRNPFLRACPQRHVFLSCQQFRQISLDTRPWNFRQKKTHVLYQLLNKSWSRGCCHQGTRKLWKHKALQKYMEDLNKEYQTLDQCLQGISENEGDRRALHRRHAQLAPLAAVYQEIQEAEQAIEELESLCKSLNKQDEKQLQELVSEERQIIDQKIHRLYSELLERLVPKEKYDWSDVILEVTSGRTTGGDICQQFTREIFDMYQNYSYYKHWKFELLNYTPADYGGLHHAAARISGDSVYKHLKYEGGIHRVQRIPEVGLSSRMQRIHTGTMSVIVLPQPDEVDVKVDPKDLRVDTFRARGAGGQHVNTTDSAVRLVHIPTGLVVECQQERSQLKNKEIALRVLRARLYQQIIEKDRCQQQNARKLQVGTRAQSERIRTYNFTQDRVTDHRIAYEVRDIKEFLRGEKCLDQLIERLLQSADEEAISEFLDESLQSVK
uniprot
proteins
function
FUNCTION: Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-canonical stop codons AGG and AGA. Non-canonical termination codons AGG and AGA are found at the end of MT-CO1/COX1 and MT-ND6/ND6 open reading frames, respectively. Recognizes non-canonical stop codons via a network of interactions between the codon, MTRF1 and the ribosomal RNA (rRNA): in contrast to other translation release factors, which identify the codon in the A-site via direct interactions of amino acid side chains with the bases, MTRF1 repositions the first 2 bases of the stop codon to use an intricate network of interactions that includes residues of the release factor, the rRNA of the small ribosomal subunit, as well as neighboring bases of the mRNA. {ECO:0000250|UniProtKB:O75570}.
uniprot
proteins
mass_dalton
52458
uniprot
proteins
post_translational_modification
PTM: Methylation of glutamine in the GGQ triplet by HEMK1 is conserved from bacteria to mammals. {ECO:0000250|UniProtKB:O75570}.
uniprot
proteins
protein_family
Prokaryotic/mitochondrial release factor family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
446
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:O75570}.
uniprot
proteins