Scd1
entrez
246074
canonical
uniprot
P07308
canonical
ensembl
ENSRNOG00000013552
resolver
ensembl
ENSRNOG00055004292
resolver
ensembl
ENSRNOG00060022548
resolver
ensembl
ENSRNOG00065029002
resolver
ensp
ENSRNOP00000018447
resolver
ensp
ENSRNOP00055005172
resolver
ensp
ENSRNOP00060032336
resolver
ensp
ENSRNOP00065041169
resolver
enst
ENSRNOT00000018447
resolver
enst
ENSRNOT00055006832
resolver
enst
ENSRNOT00060039109
resolver
enst
ENSRNOT00065050107
resolver
genesymbol
Scd1
resolver
genesymbol_syn
Scd
resolver
uniprot
Q8JZL5
resolver
uniprot_entry
ACOD1_RAT
resolver
uniprot_sec
Q8JZL5
resolver
amino_acid_sequence
MPAHMLQEISSSYTTTTTITEPPSGNLQNGREKMKKVPLYLEEDIRPEMREDIHDPSYQDEEGPPPKLEYVWRNIILMALLHVGALYGITLIPSSKVYTLLWGIFYYLISALGITAGAHRLWSHRTYKARLPLRIFLIIANTMAFQNDVYEWARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGGKLDMSDLKAEKLVMFQRRYYKPGLLLMCFILPTLVPWYCWGETFLHSLFVSTFLRYTLVLNATWLVNSAAHLYGYRPYDKNIQSRENILVSLGAVGEGFHNYHHAFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAVLARIKRTGDGSHKSS
uniprot
proteins
ec_number
1.14.19.1
uniprot
proteins
function
FUNCTION: Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates (PubMed:2892838, PubMed:7947684). Catalyzes the insertion of a cis double bond at the Delta-9 position into fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (PubMed:2892838, PubMed:7947684). Gives rise to a mixture of 16:1 and 18:1 unsaturated fatty acids. Plays an important role in lipid biosynthesis. Plays an important role in regulating the expression of genes that are involved in lipogenesis and in regulating mitochondrial fatty acid oxidation (By similarity). Plays an important role in body energy homeostasis (By similarity). Contributes to the biosynthesis of membrane phospholipids, cholesterol esters and triglycerides (PubMed:7947684). Required for normal development of sebaceous glands. Required for the biosynthesis of normal levels of Delta-9 unsaturated fatty acids and 1-alkyl-2,3-diacylglycerol in the Harderian gland. Required for normal production of meibum, an oily material that prevents drying of the cornea (By similarity). {ECO:0000250|UniProtKB:P13516, ECO:0000269|PubMed:2892838, ECO:0000269|PubMed:7947684}.
uniprot
proteins
mass_dalton
41467
uniprot
proteins
mutagenesis
MUTAGEN 119; /note="H->A: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:7947684"; MUTAGEN 124; /note="H->A: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:7947684"; MUTAGEN 156; /note="H->A: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:7947684"; MUTAGEN 157; /note="R->N: No effect on enzyme activity."; /evidence="ECO:0000269|PubMed:7947684"; MUTAGEN 159; /note="H->A: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:7947684"; MUTAGEN 160; /note="H->A: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:7947684"; MUTAGEN 166; /note="H->A: No effect on enzyme activity."; /evidence="ECO:0000269|PubMed:7947684"; MUTAGEN 170; /note="H->A: No effect on enzyme activity; when associated with H-173."; /evidence="ECO:0000269|PubMed:7947684"; MUTAGEN 173; /note="R->H: No effect on enzyme activity; when associated with A-170."; /evidence="ECO:0000269|PubMed:7947684"; MUTAGEN 297; /note="H->A: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:7947684"; MUTAGEN 300; /note="H->A: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:7947684"; MUTAGEN 301; /note="H->A: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:7947684"; MUTAGEN 315; /note="H->A: No effect on enzyme activity."; /evidence="ECO:0000269|PubMed:7947684
uniprot
proteins
protein_family
Fatty acid desaturase type 1 family
uniprot
proteins
pubmed
12419843
uniprot
proteins
pubmed
1982442
uniprot
proteins
pubmed
2428815
uniprot
proteins
pubmed
2892838
uniprot
proteins
pubmed
7947684
uniprot
proteins
sequence_length
358
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O00767}; Multi-pass membrane protein {ECO:0000305}. Membrane {ECO:0000269|PubMed:2892838}; Multi-pass membrane protein {ECO:0000269|PubMed:2892838}.
uniprot
proteins
transmembrane_region
TRANSMEM 72..92; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P13516"; TRANSMEM 97..117; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P13516"; TRANSMEM 217..236; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P13516"; TRANSMEM 241..262; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P13516
uniprot
proteins