SLC16A2
entrez
259248
canonical
uniprot
Q8K1P8
canonical
ensembl
ENSRNOG00000002832
resolver
ensembl
ENSRNOG00055026095
resolver
ensembl
ENSRNOG00060026307
resolver
ensembl
ENSRNOG00065016514
resolver
ensp
ENSRNOP00000098884
resolver
ensp
ENSRNOP00055036936
resolver
ensp
ENSRNOP00060037828
resolver
ensp
ENSRNOP00065021625
resolver
enst
ENSRNOT00000151894
resolver
enst
ENSRNOT00055045038
resolver
enst
ENSRNOT00060045564
resolver
enst
ENSRNOT00065027498
resolver
genesymbol
SLC16A2
resolver
genesymbol_syn
Mct8
resolver
uniprot
G3V9C2
resolver
uniprot_entry
MOT8_RAT
resolver
uniprot_sec
G3V9C2
resolver
amino_acid_sequence
MALPSPASEEAEGPCQEANQEYQEPVCSPVPEPEPEPEPEPEPEPEPVPVPPPEPQPEPEPQPLPDPAPLPVLGFEAEPVQEPEPTPTVETRGTARGFQPPEGGFGWIVVFAATWCNGSIFGIHNSVGILYSMLLEEEKEKNRQVEFQAAWVGALAMGMIFFCSPIVSIFTDRLGCRITATTGAAVAFIGLHTSSFTSSLSLRYFTYGILFGCGCSFAFQPSLVILGHYFQRRLGLANGVVSAGSSIFSMSFPFLIKMLGDRIKLAQTFQVLSTFMFVLTLLSLTYRPLLPSSQDTPSKRGAHTLRQRFLVQFRKYFNMRVFRQRTYRIWAFGIAAAALGYFVPYVHLMKYVEDKFKEIKETWVLLVCIGATSGLGRLVSGHISDSIPGLKKIYLQVLSFLLLGLMSMMIPLCRDFGGLIVVCLFLGLCDGFFITIMAPIAFELVGPMQASQAIGYLLGMMALPMIAGPPIAGLLRNCFGNYHVAFYFAGVPPIIGAVILFFVPLMHQRMFKKEQRESSKDKMLSHDPDPNGELLPGSPTPEEPI
uniprot
proteins
function
FUNCTION: Specific thyroid hormone transmembrane transporter, that mediates both uptake and efflux of thyroid hormone across the cell membrane independently of pH or a Na(+) gradient. Major substrates are the iodothyronines T3 and T4 and to a lesser extent rT3 and 3,3-diiodothyronine (3,3'-T2) (PubMed:12871948). Acts as an important mediator of thyroid hormone transport, especially T3, through the blood-brain barrier (By similarity). Mediates the efflux of 3,5-diiodo-L-tyrosine (DIT) and 3-iodo-L-tyrosine (MIT) (By similarity). {ECO:0000250|UniProtKB:P36021, ECO:0000269|PubMed:12871948}.
uniprot
proteins
mass_dalton
60050
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Monocarboxylate porter (TC 2.A.1.13) family
uniprot
proteins
pubmed
12871948
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
18687783
uniprot
proteins
sequence_length
545
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12871948, ECO:0000269|PubMed:18687783}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P36021}. Apical cell membrane {ECO:0000269|PubMed:18687783}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P36021}. Note=Detected at the luminal and abluminal membrane surfaces of microvessels. {ECO:0000269|PubMed:18687783}.
uniprot
proteins
transmembrane_region
TRANSMEM 103..123; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P36021"; TRANSMEM 150..170; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P36021"; TRANSMEM 182..202; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P36021"; TRANSMEM 205..225; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P36021"; TRANSMEM 236..256; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P36021"; TRANSMEM 265..285; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P36021"; TRANSMEM 329..349; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P36021"; TRANSMEM 363..383; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P36021"; TRANSMEM 393..413; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:P36021"; TRANSMEM 416..436; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:P36021"; TRANSMEM 454..474; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:P36021"; TRANSMEM 484..504; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:P36021
uniprot
proteins