Arrdc1
entrez
366001
canonical
uniprot
B0BNL6
canonical
ensembl
ENSRNOG00000007622
resolver
ensembl
ENSRNOG00055000475
resolver
ensembl
ENSRNOG00060023510
resolver
ensembl
ENSRNOG00065023244
resolver
ensp
ENSRNOP00000010169
resolver
ensp
ENSRNOP00000105854
resolver
ensp
ENSRNOP00055000629
resolver
ensp
ENSRNOP00060033674
resolver
ensp
ENSRNOP00065032296
resolver
enst
ENSRNOT00000010169
resolver
enst
ENSRNOT00000160561
resolver
enst
ENSRNOT00055000815
resolver
enst
ENSRNOT00060040734
resolver
enst
ENSRNOT00065039708
resolver
genesymbol
Arrdc1
resolver
uniprot
A0ABK0LVY7
resolver
uniprot
Q68FT0
resolver
uniprot_entry
A0ABK0LVY7_RAT
resolver
uniprot_entry
ARRD1_RAT
resolver
uniprot_sec
Q68FT0
resolver
amino_acid_sequence
MGRVQLFEIRLSQGRVVYSPGEPLAGAVHLRLGAPLPFRAIRVTCMGSCGVSNKANDGAWVVEESYFNSSLSLADKGSLPPGEHNFPFQFLLPATAPTSFEGPFGKIVHQVRASIDTPRFSKDHKCSLVFYILSPLNLNSIPDIEQPNVASTTKKFSYKLVKTGSVVLTASTDLRGYVVGQVLRLQADIENQSGKDTSPVVASLLQKVSYKAKRWIYDVRTIAEVEGTGVKAWRHAQWQEQILVPALPQSALPGCSLIHIDYYLQVSMKAPEATVTLPLFVGNIAVNQTPLSPCPGPGSSPGLLSPVVPSAPPQEEAEAVASGPHFSDPVSLSTKSHSQQQPLSTTLGSVSVTTIEPCVQVGSPARHSLHPPLCISIGATVPYFAEGSGGPVPTTSALILPPEYSSWGYPYEAPPSYEQSCGAGGTDVGLIPGS
uniprot
proteins
function
FUNCTION: Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles. More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles. By participating in the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway. {ECO:0000250|UniProtKB:Q8N5I2}.
uniprot
proteins
mass_dalton
46109
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Ubiquitination by WWP2; promotes localization to extracellular microvesicles. Ubiquitinated by WWP1. {ECO:0000250|UniProtKB:Q8N5I2}.
uniprot
proteins
protein_family
Arrestin family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23886940
uniprot
proteins
sequence_length
434
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8N5I2}. Note=Also found in extracellular vesicles different from exosomes. {ECO:0000250|UniProtKB:Q8N5I2}.
uniprot
proteins