TASL
entrez
80231
canonical
uniprot
Q9HAI6
canonical
ensembl
ENSG00000120280
resolver
ensp
ENSP00000368245
resolver
ensp
ENSP00000625885
resolver
ensp
ENSP00000625886
resolver
enst
ENST00000378962
resolver
enst
ENST00000955826
resolver
enst
ENST00000955827
resolver
genesymbol
TASL
resolver
genesymbol_syn
CXorf21
resolver
hgnc
HGNC:25667
resolver
uniprot_entry
TASL_HUMAN
resolver
amino_acid_sequence
MLSEGYLSGLEYWNDIHWSCASYNEQVAGEKEEETNSVATLSYSSVDETQVRSLYVSCKSSGKFISSVHSRESQHSRSQRVTVLQTNPNPVFESPNLAAVEICRDASRETYLVPSSCKSICKNYNDLQIAGGQVMAINSVTTDFPSESSFEYGPLLKSSEIPLPMEDSISTQPSDFPQKPIQRYSSYWRITSIKEKSSLQMQNPISNAVLNEYLEQKVVELYKQYIMDTVFHDSSPTQILASELIMTSVDQISLQVSREKNLETSKARDIVFSRLLQLMSTEITEISTPSLHISQYSNVNP
uniprot
proteins
disease_involvement
DISEASE: Note=Some alleles may be associated with systemic lupus erythematosus (SLE); a chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Because it evades X-chromosome inactivation, its expression is increased in female immune cells which may be involved to SLE striking sex imbalance towards females. {ECO:0000269|PubMed:31001245, ECO:0000269|PubMed:31092820}.
uniprot
proteins
function
FUNCTION: Innate immune adapter that mediates the recruitment and activation of IRF5 downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:32433612). Following recruitment to endolysosome by SLC15A4 downstream of TLR7, TLR8 and TLR9, specifically recruits IRF5 transcription factor via its pLxIS motif, leading to IRF5 activation and subsequent expression of type I interferons (PubMed:32433612). Plays a role in the regulation of endolysosomal pH in immune cells such as B-cells, dendritic cells and monocytes (PubMed:31001245). {ECO:0000269|PubMed:31001245, ECO:0000269|PubMed:32433612}.
uniprot
proteins
mass_dalton
33894
uniprot
proteins
mutagenesis
MUTAGEN 294; /note="S->A: Abolished ability to activate IRF5."; /evidence="ECO:0000269|PubMed:32433612"; MUTAGEN 294; /note="S->D: Phosphomimetic mutant; retains ability to activate IRF5."; /evidence="ECO:0000269|PubMed:32433612
uniprot
proteins
post_translational_modification
PTM: The phosphorylated pLxIS motif constitutes an IRF5-binding motif, leading to recruitment of the transcription factor IRF5 to induce type-I interferons and other cytokines. {ECO:0000305|PubMed:32433612}.
uniprot
proteins
protein_family
TASL protein family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
31001245
uniprot
proteins
pubmed
31092820
uniprot
proteins
pubmed
32433612
uniprot
proteins
pubmed
39719710
uniprot
proteins
sequence_length
301
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:31092820, ECO:0000269|PubMed:32433612}. Endosome membrane {ECO:0000269|PubMed:32433612}. Nucleus {ECO:0000269|PubMed:31092820}. Cytoplasm {ECO:0000269|PubMed:31092820}. Note=Recruited to endolysosome following interaction with SLC15A4 (PubMed:32433612, PubMed:39719710). May colocalize with TLR7 in the endosomal pathway (PubMed:31092820). {ECO:0000269|PubMed:31092820, ECO:0000269|PubMed:32433612, ECO:0000269|PubMed:39719710}.
uniprot
proteins