NYX
entrez
60506
canonical
uniprot
Q9GZU5
canonical
ensembl
ENSG00000188937
resolver
ensp
ENSP00000340328
resolver
ensp
ENSP00000367465
resolver
ensp
ENSP00000608210
resolver
enst
ENST00000342595
resolver
enst
ENST00000378220
resolver
enst
ENST00000938151
resolver
genesymbol
NYX
resolver
genesymbol_syn
CLRP
resolver
hgnc
HGNC:8082
resolver
uniprot
D3DWC0
resolver
uniprot
Q2M1S4
resolver
uniprot
Q5H983
resolver
uniprot
Q9H4J0
resolver
uniprot_entry
NYX_HUMAN
resolver
uniprot_sec
D3DWC0
resolver
uniprot_sec
Q2M1S4
resolver
uniprot_sec
Q5H983
resolver
uniprot_sec
Q9H4J0
resolver
amino_acid_sequence
MLVLLLHAVVLGLPSAWAVGACARACPAACACSTVERGCSVRCDRAGLLRVPAELPCEAVSIDLDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPALRELAAFDNLFRRVPGALRGLANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRNPWCCDCRLEWLRDWMEGSGRVTDVPCASPGSVAGLDLSQVTFGRSSDGLCVDPEELNLTTSSPGPSPEPAATTVSRFSSLLSKLLAPRVPVEEAANTTGGLANASLSDSLSSRGVGGAGRQPWFLLASCLLPSVAQHVVFGLQMD
uniprot
proteins
disease_involvement
DISEASE: Night blindness, congenital stationary, 1A (CSNB1A) [MIM:310500]: A non-progressive retinal disorder characterized by impaired night vision. Congenital stationary night blindness type 1A is characterized by impaired scotopic vision, myopia, hyperopia, nystagmus and reduced visual acuity. {ECO:0000269|PubMed:11062471, ECO:0000269|PubMed:11062472}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Required for normal vision. Is a critical factor for light-induced depolarization of retinal ON-bipolar cells, likely acting as a scaffold for TRPM1 and GRM6. Required for TRPM1 trafficking to dendritic tips of ON-bipolar cells. {ECO:0000250|UniProtKB:P83503}.
uniprot
proteins
mass_dalton
51470
uniprot
proteins
protein_family
SLRP class IV subfamily
uniprot
proteins
protein_family
Small leucine-rich proteoglycan (SLRP) family
uniprot
proteins
pubmed
11062471
uniprot
proteins
pubmed
11062472
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
sequence_length
476
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}. Cell projection, dendrite {ECO:0000250|UniProtKB:P83503}. Postsynapse {ECO:0000250|UniProtKB:P83503}. Note=In the retina, localized postsynaptically at the dendritic tips of ON-bipolar cells. {ECO:0000250|UniProtKB:P83503}.
uniprot
proteins