P2RX6
entrez
9127
canonical
uniprot
O15547
canonical
ensembl
ENSG00000099957
resolver
ensp
ENSP00000385309
resolver
ensp
ENSP00000416193
resolver
ensp
ENSP00000628169
resolver
ensp
ENSP00000628172
resolver
ensp
ENSP00000628175
resolver
ensp
ENSP00000698810
resolver
ensp
ENSP00000698817
resolver
genesymbol
P2RX6
resolver
genesymbol_syn
P2RXL1
resolver
genesymbol_syn
P2X6
resolver
hgnc
HGNC:8538
resolver
uniprot
F6V3D7
resolver
uniprot
Q32MB6
resolver
uniprot
Q58F04
resolver
uniprot
Q6IC33
resolver
uniprot
Q9UL50
resolver
uniprot_entry
P2RX6_HUMAN
resolver
uniprot_sec
F6V3D7
resolver
uniprot_sec
Q32MB6
resolver
uniprot_sec
Q58F04
resolver
uniprot_sec
Q6IC33
resolver
uniprot_sec
Q9UL50
resolver
amino_acid_sequence
MCPQLAGAGSMGSPGATTGWGLLDYKTEKYVMTRNWRVGALQRLLQFGIVVYVVGWALLAKKGYQERDLEPQFSIITKLKGVSVTQIKELGNRLWDVADFVKPPQGENVFFLVTNFLVTPAQVQGRCPEHPSVPLANCWVDEDCPEGEGGTHSHGVKTGQCVVFNGTHRTCEIWSWCPVESGVVPSRPLLAQAQNFTLFIKNTVTFSKFNFSKSNALETWDPTYFKHCRYEPQFSPYCPVFRIGDLVAKAGGTFEDLALLGGSVGIRVHWDCDLDTGDSGCWPHYSFQLQEKSYNFRTATHWWEQPGVEARTLLKLYGIRFDILVTGQAGKFGLIPTAVTLGTGAAWLGVVTFFCDLLLLYVDREAHFYWRTKYEEAKAPKATANSVWRELALASQARLAECLRRSSAPAPTATAAGSQTQTPGWPCPSSDTHLPTHSGSL
uniprot
proteins
function
FUNCTION: May act as a modulatory subunit rather than a functional channel. Unlike other P2XRs members, P2RX6 does not seem to form functional homotrimers (PubMed:22378790). P2RX6 requires the presence of P2RX4 or P2RX2 to shuttle it to the plasma membrane where it may form functional heterotrimeric receptors at the plasma membrane (PubMed:22378790). P2RX6 can be translocated to the nucleus and functions as a nuclear regulator of post-transcriptional modifications in neurons (By similarity). {ECO:0000250|UniProtKB:O54803, ECO:0000269|PubMed:22378790}.
uniprot
proteins
mass_dalton
48829
uniprot
proteins
post_translational_modification
PTM: N-glycosylated (PubMed:15657042). N-linked glycosylation can affect trafficking to the membrane and function (By similarity). {ECO:0000250|UniProtKB:P51579, ECO:0000269|PubMed:15657042}.
uniprot
proteins
protein_family
P2X receptor family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
12112843
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15657042
uniprot
proteins
pubmed
22378790
uniprot
proteins
pubmed
9242461
uniprot
proteins
sequence_length
441
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P51579}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P51579}. Nucleus {ECO:0000250|UniProtKB:O54803}. Nucleus inner membrane {ECO:0000250|UniProtKB:O54803}; Multi-pass membrane protein {ECO:0000255}. Note=Heteromerization of P2RX6 subunits with either P2RX2 or P2RX4 subunits guides the P2RX6 subunit to the plasma membrane (By similarity). Monomers remain anchored to the endoplasmic reticulum (ER) membrane by the hydrophobic N-terminal end (By similarity). Mainly expressed in the cell body of the hippocampal neurons (By similarity). {ECO:0000250|UniProtKB:O54803, ECO:0000250|UniProtKB:P51579}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..60; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 334..354; /note="Helical; Name=2"; /evidence="ECO:0000255
uniprot
proteins