Pxn
entrez
360820
canonical
uniprot
Q66H76
canonical
ensembl
ENSRNOG00000001149
resolver
ensp
ENSRNOP00000043928
resolver
ensp
ENSRNOP00000061647
resolver
ensp
ENSRNOP00000081906
resolver
ensp
ENSRNOP00000089712
resolver
ensp
ENSRNOP00000095501
resolver
enst
ENSRNOT00000064115
resolver
enst
ENSRNOT00000105395
resolver
enst
ENSRNOT00000112063
resolver
enst
ENSRNOT00000113962
resolver
genesymbol
Pxn
resolver
uniprot
A0A8I5ZUE4
resolver
uniprot
A0A8I6AAE7
resolver
uniprot
A0A8I6AJT3
resolver
uniprot
F7FID5
resolver
uniprot
Q1EG89
resolver
uniprot_entry
A0A8I5ZUE4_RAT
resolver
uniprot_entry
A0A8I6AAE7_RAT
resolver
uniprot_entry
A0A8I6AJT3_RAT
resolver
uniprot_entry
F7FID5_RAT
resolver
uniprot_entry
PAXI_RAT
resolver
uniprot_entry
Q1EG89_RAT
resolver
amino_acid_sequence
MDDLDALLADLESTTSHISKRPVFLSEEPPYSYPTGNHTYQEIAVPPPVPPPPSSEALNGTVLDPLDQWQPSGSRYAHQQPPSPSPIYSSSTKNSSASNPQDSVGSLCSRAGEEEHVYSFPNKQKSAEPSPTVMSSSLGSNLSELDRLLLELNAVQRSPSGFSAGMVSVQASREPLGSWGTEGRAIILSPFFQDEAESSPPLPGALSPLYGVPESNNLLGGKAGPLMKEKPKRNGGRGLEDVRPSVESLLDELENSVPSPVPAITVNQGEMSSPQRVTSSQQQTRISASSATRELDELMASLSDFKFMAQGKTGSSSPPGGLSKPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHSLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQSCFLKLFC
uniprot
proteins
function
FUNCTION: Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000250|UniProtKB:P49023}.
uniprot
proteins
mass_dalton
64019
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MAPK1/ERK2 (By similarity). Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens. Phosphorylation at Ser-273 by CDK5 reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation (By similarity). Phosphorylation at Tyr-31 and Tyr-118 by PTK6 promote the activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion (By similarity). Phosphorylation at Ser-279 by SLK is required for PXN redistribution and cell motility (By similarity). Phosphorylation at Ser-301 promotes focal adhesion disassembly during cell migration (By similarity). {ECO:0000250|UniProtKB:P49023}.
uniprot
proteins
protein_family
Paxillin family
uniprot
proteins
pubmed
11134073
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16546139
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
586
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P49023}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P49023}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q8VI36}. Note=Colocalizes with integrins at the cell periphery. Colocalizes with PXN to membrane ruffles and the leading edge of migrating cells (By similarity). {ECO:0000250|UniProtKB:P49023}.
uniprot
proteins