Scrib
entrez
105782
canonical
uniprot
Q80U72
canonical
ensembl
ENSMUSG00000022568
resolver
ensp
ENSMUSP00000002603
resolver
ensp
ENSMUSP00000068056
resolver
ensp
ENSMUSP00000105572
resolver
ensp
ENSMUSP00000287373
resolver
ensp
ENSMUSP00000287374
resolver
ensp
ENSMUSP00000287378
resolver
genesymbol
Scrib
resolver
genesymbol_syn
Kiaa0147
resolver
genesymbol_syn
Lap4
resolver
genesymbol_syn
Scrib1
resolver
uniprot
Q6P5H7
resolver
uniprot
Q7TPH8
resolver
uniprot
Q80VB1
resolver
uniprot
Q8CI48
resolver
uniprot
Q8VII1
resolver
uniprot
Q922S3
resolver
uniprot_entry
SCRIB_MOUSE
resolver
uniprot_sec
Q6P5H7
resolver
uniprot_sec
Q7TPH8
resolver
uniprot_sec
Q80VB1
resolver
uniprot_sec
Q8CI48
resolver
uniprot_sec
Q8VII1
resolver
uniprot_sec
Q922S3
resolver
amino_acid_sequence
MLKCIPLWRCNRHVESVDKRHCSLQVVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPVELGGLALLTDLLLSQNLLQRLPEGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLTALPHSLGKLTKLTNLNVDRNHLEVLPPEIGGCVALSVLSLRDNRLAVLPPELAHTAELHVLDVAGNRLRSLPFALTHLNLKALWLAENQAQPMLRFQTEDDAQTGEKVLTCYLLPQQPLPSLEDAGQQSSPSESCSDAPLSRVSVIQFEDTLEGEEDAEEAAAEKRGLQRRATPHPSELKVMKRGIEERRNEAFVCKPDPSPPSPSEEEKRLSAESALSGGSVPSASTASEGEPEILPAEVQGLGQHEAMPAQEEYTEDDYNEPTVHFAEDTLIPREDGESEEGQPEAAWPLPSGRQRLIRKDTPHYKKHFKISKLPQPEAVVALLQGVQTDREGPTAGWHNGPHTPWAPRAHEEEEEEEEENRDEEEGEATTEEDDKEEAVASAPSVKGVSFDQANNLLIEPARIEEEELTLTIVRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQDAEHHEAVEALRGAGAAVQMRVWRERMVEPENAVTITPLRPEDDYSPREWRGGGLRLPLLQPETPVSLRQRHAACLVRSEKGLGFSIAGGKGSTPYRAGDGGIFISRIAEGGAAHRAGTLQVGDRVLSINGVDMTEARHDHAVSLLTAASPTISLLLERETGGTYPPSPPPHSSPTPAATVAATVSTAVPGEPLLPRLSPSLLATALEGPYPVEEICLPRAGGPLGLSIVGGSDHSSHPFGVQDPGVFISKVLPRGLAARCGLRVGDRILAVNGQDVREATHQEAVSALLRPCLELCLLVRRDPPPPGMRELCIQKAPGEKLGISIRGGAKGHAGNPCDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHAEAVQLLRSVGDTLTVLVCDGFDTSTTTALEVSPGVIANPFAAGLGHRNSLESISSIDRELSPEGPGKEKELASQALPWESESAETTGRNLEPLKLDYRALAALPSAGSLQRGPSATTGGKTTEAPCSPGSQQTKPGVIQPLAQAWPRNSPAPRGRGGPCSPPSPDELPANVKQAYRAFAAVPTVHPPENSATQPPTPGPAASPEQLSFRERQKYFELEVRVPQAEGPPKRVSLVGADDLRKMQEEEARKLQQKRAQMLREEAVTSGPDMGLASDRESPDDQQEAEQPWAVPSHAGGSSPSSPPPLGGNAPVRTAKAERRHQERLRMQSPELPAPERALSPAERRALEAEKRALWRAARMKSLEQDALRAQMVLSKSQEGRGKRGPLERLAEAPSPAPTPSPTPLEDFGLQTSASPGRLPLSGKKFDYRAFAALPSSRPVYDIQSPDFVEELRTLEASPSPGSQEEDGEVALVLLGRPSPGAVGPEDMTLCSSRRSVRPGRRGLGPVPS
uniprot
proteins
function
FUNCTION: Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:12499390, PubMed:18329370, PubMed:18716323, PubMed:19041750). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (PubMed:18329370). Plays a role in cell directional movement, cell orientation, cell sheet organization and Golgi complex polarization at the cell migration front (By similarity). Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). Most probably functions in the establishment of apico-basal cell polarity (PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:19041750). May regulate cell invasion via MAPK-mediated cell migration and adhesion (PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:19458197). Functions as an activator of Rac GTPase activity (By similarity). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q14160, ECO:0000269|PubMed:12499390, ECO:0000269|PubMed:18329370, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750, ECO:0000269|PubMed:19458197}.
uniprot
proteins
mass_dalton
179750
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; targeted for UBE3A-dependent multiubiquitination and degraded. {ECO:0000250}.; PTM: Palmitoylated. Could be depalmitoylated by LYPLA1 and/or LYPLA2. Palmitoylation of SCRIB by ZDHHC7 is required for its localization to cell-cell junctions, function in the establishement of epithelial cell polarity and the regulation of downstream signaling pathways important for epithelial cell differentiation. {ECO:0000250|UniProtKB:Q14160}.
uniprot
proteins
protein_family
LAP (LRR and PDZ) protein family
uniprot
proteins
pubmed
12499390
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15182672
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15649318
uniprot
proteins
pubmed
15806148
uniprot
proteins
pubmed
15878399
uniprot
proteins
pubmed
16611247
uniprot
proteins
pubmed
16687519
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18329370
uniprot
proteins
pubmed
18716323
uniprot
proteins
pubmed
19041750
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19386766
uniprot
proteins
pubmed
19458197
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
1665
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18329370}; Peripheral membrane protein {ECO:0000269|PubMed:18329370}. Cell junction {ECO:0000250|UniProtKB:Q14160}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q14160}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q14160}. Cytoplasm {ECO:0000250|UniProtKB:Q14160}. Postsynapse {ECO:0000250|UniProtKB:Q14160}. Presynapse {ECO:0000250|UniProtKB:Q14160}. Note=Targeting to cell-cell junctions which is CDH1-dependent is required for the pro-apoptotic activity (By similarity). In a subset of CD4+ T-cells, colocalizes with CRTAM at the immunological synapse during the late phase of T-cell activation (PubMed:18329370). Localized to small puncta throughout the cytoplasm and cell membrane when in the presence of SNAIL1 (By similarity). Localized along the length of perinuclear emanating vimentin bundles and at vimentin-positive fibrils at the cell periphery (By similarity). Localized to the lateral plasma membrane during the establishment and maturation of cell-cell contacts (By similarity). {ECO:0000250|UniProtKB:A0A8P0N4K0, ECO:0000250|UniProtKB:Q14160, ECO:0000269|PubMed:18329370}.
uniprot
proteins