FSTL3
entrez
10272
canonical
uniprot
O95633
canonical
ensembl
ENSG00000070404
resolver
ensp
ENSP00000166139
resolver
genesymbol
FSTL3
resolver
genesymbol_syn
FLRG
resolver
hgnc
HGNC:3973
resolver
uniprot
A8K7E3
resolver
uniprot_entry
FSTL3_HUMAN
resolver
uniprot_sec
A8K7E3
resolver
amino_acid_sequence
MRPGAPGPLWPLPWGALAWAVGFVSSMGSGNPAPGGVCWLQQGQEATCSLVLQTDVTRAECCASGNIDTAWSNLTHPGNKINLLGFLGLVHCLPCKDSCDGVECGPGKACRMLGGRPRCECAPDCSGLPARLQVCGSDGATYRDECELRAARCRGHPDLSVMYRGRCRKSCEHVVCPRPQSCVVDQTGSAHCVVCRAAPCPVPSSPGQELCGNNNVTYISSCHMRQATCFLGRSIGVRHAGSCAGTPEEPPGGESAEEEENFV
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1. {ECO:0000269|PubMed:9671416}.
uniprot
proteins
function
FUNCTION: Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such as activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiation. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10. {ECO:0000269|PubMed:11948405, ECO:0000269|PubMed:15451575, ECO:0000269|PubMed:15574124, ECO:0000269|PubMed:16336961, ECO:0000269|PubMed:17868029, ECO:0000269|PubMed:17878677}.
uniprot
proteins
mass_dalton
27663
uniprot
proteins
mutagenesis
MUTAGEN 27; /note="M->A: Nuclear localization."; /evidence="ECO:0000269|PubMed:16150905
uniprot
proteins
pubmed
11459787
uniprot
proteins
pubmed
11948405
uniprot
proteins
pubmed
12697670
uniprot
proteins
pubmed
12970321
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15451575
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15574124
uniprot
proteins
pubmed
16150905
uniprot
proteins
pubmed
16336961
uniprot
proteins
pubmed
17868029
uniprot
proteins
pubmed
17878677
uniprot
proteins
pubmed
18768470
uniprot
proteins
pubmed
22052913
uniprot
proteins
pubmed
26091039
uniprot
proteins
pubmed
9671416
uniprot
proteins
sequence_length
263
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Secreted.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus. Note=Although alternative initiation has been demonstrated and resulted in different localization, the major source of nuclear FSTL3 appears not to depend on translation initiation at Met-27 according to. {ECO:0000269|PubMed:16150905}.
uniprot
proteins