SLPI
entrez
6590
canonical
uniprot
P03973
canonical
ensembl
ENSG00000124107
resolver
ensp
ENSP00000342082
resolver
enst
ENST00000338380
resolver
genesymbol
SLPI
resolver
genesymbol_syn
WAP4
resolver
genesymbol_syn
WFDC4
resolver
hgnc
HGNC:11092
resolver
uniprot
B2R5H8
resolver
uniprot
P07757
resolver
uniprot_entry
SLPI_HUMAN
resolver
uniprot_sec
B2R5H8
resolver
uniprot_sec
P07757
resolver
amino_acid_sequence
MKSSGLFPFLVLLALGTLAPWAVEGSGKSFKAGVCPPKKSAQCLRYKKPECQSDWQCPGKKRCCPDTCGIKCLDPVDTPNPTRRKPGKCPVTYGQCLMLNPPNFCEMDGQCKRDLKCCMGMCGKSCVSPVKA
uniprot
proteins
function
FUNCTION: Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G (PubMed:10702419, PubMed:2039600, PubMed:2110563, PubMed:24121345, PubMed:3462719, PubMed:3533531). Modulates the inflammatory and immune responses after bacterial infection, and after infection by the intracellular parasite L.major. Down-regulates responses to bacterial lipopolysaccharide (LPS) (By similarity). Plays a role in regulating the activation of NF-kappa-B and inflammatory responses (PubMed:10702419, PubMed:24352879). Has antimicrobial activity against mycobacteria, but not against salmonella. Contributes to normal resistance against infection by M.tuberculosis. Required for normal resistance to infection by L.major. Required for normal wound healing, probably by preventing tissue damage by limiting protease activity (By similarity). Together with ELANE, required for normal differentiation and proliferation of bone marrow myeloid cells (PubMed:24352879). {ECO:0000250|UniProtKB:P97430, ECO:0000269|PubMed:10702419, ECO:0000269|PubMed:2039600, ECO:0000269|PubMed:2110563, ECO:0000269|PubMed:24121345, ECO:0000269|PubMed:24352879, ECO:0000269|PubMed:3462719, ECO:0000269|PubMed:3533531, ECO:0000305}.
uniprot
proteins
mass_dalton
14326
uniprot
proteins
mutagenesis
MUTAGEN 45; /note="R->G: No significant effect on inhibition of elastase, trypsin and chymotrypsin."; /evidence="ECO:0000269|PubMed:10702419, ECO:0000269|PubMed:2110563"; MUTAGEN 45; /note="R->M,V: No significant effect on inhibition of elastase, trypsin and chymotrypsin."; /evidence="ECO:0000269|PubMed:2110563"; MUTAGEN 97; /note="L->F: Increases inhibition of chymotrypsin."; /evidence="ECO:0000269|PubMed:10702419, ECO:0000269|PubMed:2110563"; MUTAGEN 97; /note="L->G: Reduced inhibition of elastase. Strongly reduced inhibition of chymotrypsin and trypsin."; /evidence="ECO:0000269|PubMed:10702419, ECO:0000269|PubMed:2110563"; MUTAGEN 97; /note="L->K,R: Strongly reduced inhibition of elastase. Abolishes inhibition of trypsin."; /evidence="ECO:0000269|PubMed:10702419, ECO:0000269|PubMed:2110563"; MUTAGEN 98; /note="M->G: No significant effect on inhibition of elastase, trypsin and chymotrypsin."; /evidence="ECO:0000269|PubMed:2110563"; MUTAGEN 99; /note="L->G: No significant effect on inhibition of elastase, trypsin and chymotrypsin."; /evidence="ECO:0000269|PubMed:2110563
uniprot
proteins
pubmed
10702419
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12526812
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18421166
uniprot
proteins
pubmed
2039600
uniprot
proteins
pubmed
2110563
uniprot
proteins
pubmed
24121345
uniprot
proteins
pubmed
24352879
uniprot
proteins
pubmed
25946035
uniprot
proteins
pubmed
3366116
uniprot
proteins
pubmed
3462719
uniprot
proteins
pubmed
3485543
uniprot
proteins
pubmed
3533531
uniprot
proteins
pubmed
3640338
uniprot
proteins
sequence_length
132
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2039600, ECO:0000269|PubMed:24352879, ECO:0000269|PubMed:3462719, ECO:0000269|PubMed:3485543}.
uniprot
proteins