CCSAP
entrez
126731
canonical
uniprot
Q6IQ19
canonical
ensembl
ENSG00000154429
resolver
ensp
ENSP00000284617
resolver
ensp
ENSP00000355647
resolver
genesymbol
CCSAP
resolver
genesymbol_syn
C1orf96
resolver
genesymbol_syn
CSAP
resolver
hgnc
HGNC:29578
resolver
uniprot
A8K5X2
resolver
uniprot
Q6P9G2
resolver
uniprot
Q6ZW85
resolver
uniprot
Q8IXU1
resolver
uniprot
Q96BM2
resolver
uniprot_entry
CCSAP_HUMAN
resolver
uniprot_sec
A8K5X2
resolver
uniprot_sec
Q6P9G2
resolver
uniprot_sec
Q6ZW85
resolver
uniprot_sec
Q8IXU1
resolver
uniprot_sec
Q96BM2
resolver
amino_acid_sequence
MSPGSGVKSEYMKRYQEPRWEEYGPCYRELLHYRLGRRLLEQAHAPWLWDDWGPAGSSEDSASSESSGAGGPAPRCAPPSPPPPVEPATQEEAERRARGAPEEQDAEAGDAEAEDAEDAALPALPVKDVEDKPEQQTRTRETDKSPTSTEPRQQPSALFARGNRKAVKSPQRSSSKIKENKHPFALYGWGEKQTDTGSQKTHNVCASAPVHEIHESALRAKNRRQVEKRKLVAQRQRAHSVDVEKNRKMKASSSENPWMTEYMRCYSARA
uniprot
proteins
function
FUNCTION: Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis. Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle (PubMed:26562023). May play a role in embryonic development. May be required for proper cilia beating (By similarity). {ECO:0000250|UniProtKB:Q6P3G4, ECO:0000269|PubMed:26562023}.
uniprot
proteins
mass_dalton
30216
uniprot
proteins
protein_family
CCSAP family
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
22493317
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
26562023
uniprot
proteins
sequence_length
270
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:22493317}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:22493317, ECO:0000269|PubMed:26562023}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22493317}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:22493317}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:22493317}. Cell projection, axon {ECO:0000269|PubMed:22493317}. Cell projection, cilium {ECO:0000269|PubMed:22493317}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:26562023}. Note=Localizes to two to four centrioles throughout the cell cycle. Localizes to mitotic spindle microtubules during prometaphase and throughout the remainder of mitosis. Localizes to cytoskeleton on interphase. Localizes at the ciliary transition zone which connects the basal bodies to ciliary microtubules. Colocalizes with polyglutamylated tubulin. {ECO:0000269|PubMed:22493317, ECO:0000269|PubMed:26562023}.
uniprot
proteins