HSD17B1
entrez
3292
canonical
uniprot
P14061
canonical
ensembl
ENSG00000108786
resolver
ensp
ENSP00000225929
resolver
ensp
ENSP00000466799
resolver
enst
ENST00000225929
resolver
enst
ENST00000585807
resolver
genesymbol
HSD17B1
resolver
genesymbol_syn
E17KSR
resolver
genesymbol_syn
EDH17B1
resolver
genesymbol_syn
EDH17B2
resolver
genesymbol_syn
EDHB17
resolver
genesymbol_syn
SDR28C1
resolver
hgnc
HGNC:5210
resolver
uniprot
A0A0A0MQS7
resolver
uniprot
B3KXS1
resolver
uniprot
Q2M2L8
resolver
uniprot_entry
A0A0A0MQS7_HUMAN
resolver
uniprot_entry
DHB1_HUMAN
resolver
uniprot_sec
B3KXS1
resolver
uniprot_sec
Q2M2L8
resolver
amino_acid_sequence
MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGGGAGPGAEDEAGRGAVGDPELGDPPAAPQ
uniprot
proteins
ec_number
1.1.1.51
uniprot
proteins
ec_number
1.1.1.62
uniprot
proteins
function
FUNCTION: Favors the reduction of estrogens and androgens. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2) (PubMed:8994190). Also has 20-alpha-HSD activity. Uses preferentially NADH. {ECO:0000269|PubMed:8994190}.
uniprot
proteins
mass_dalton
34950
uniprot
proteins
mutagenesis
MUTAGEN 112..114; /note="LDV->F: Loss of 17-beta-hydroxysteroid dehydrogenase activity."; /evidence="ECO:0000269|PubMed:8994190"; MUTAGEN 135; /note="S->A: Abolishes phosphorylation. No effect on 17-beta-hydroxysteroid dehydrogenase activity."; /evidence="ECO:0000269|PubMed:8994190"; MUTAGEN 143; /note="S->A: Loss of 17-beta-hydroxysteroid dehydrogenase activity."; /evidence="ECO:0000269|PubMed:8994190"; MUTAGEN 150; /note="L->V: Alters substrate specificity."; /evidence="ECO:0000269|PubMed:10625652"; MUTAGEN 156; /note="Y->A: Loss of 17-beta-hydroxysteroid dehydrogenase activity."; /evidence="ECO:0000269|PubMed:8994190"; MUTAGEN 160; /note="K->A: Loss of 17-beta-hydroxysteroid dehydrogenase activity."; /evidence="ECO:0000269|PubMed:8994190"; MUTAGEN 171; /note="A->AEF: Loss of 17-beta-hydroxysteroid dehydrogenase activity."; /evidence="ECO:0000269|PubMed:8994190"; MUTAGEN 222; /note="H->A: No effect on conversion of estrone to 17beta-estradiol."; /evidence="ECO:0000269|PubMed:8994190"; MUTAGEN 283; /note="E->A: No effect on conversion of estrone to 17beta-estradiol."; /evidence="ECO:0000269|PubMed:8994190"; MUTAGEN 283; /note="E->Q: No effect on conversion of estrone to 17beta-estradiol."; /evidence="ECO:0000269|PubMed:8994190
uniprot
proteins
pathway_participation
PATHWAY: Steroid biosynthesis; estrogen biosynthesis. {ECO:0000269|PubMed:8994190}.
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
10625652
uniprot
proteins
pubmed
12223444
uniprot
proteins
pubmed
12490543
uniprot
proteins
pubmed
1327779
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14966133
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
2197970
uniprot
proteins
pubmed
2330005
uniprot
proteins
pubmed
2547159
uniprot
proteins
pubmed
2779584
uniprot
proteins
pubmed
2846351
uniprot
proteins
pubmed
3456799
uniprot
proteins
pubmed
4719204
uniprot
proteins
pubmed
5045524
uniprot
proteins
pubmed
6578212
uniprot
proteins
pubmed
7663947
uniprot
proteins
pubmed
8389226
uniprot
proteins
pubmed
8756321
uniprot
proteins
pubmed
8805577
uniprot
proteins
pubmed
8994190
uniprot
proteins
pubmed
9525918
uniprot
proteins
pubmed
9927655
uniprot
proteins
sequence_length
328
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins