Dmrt1
entrez
50796
canonical
uniprot
Q9QZ59
canonical
ensembl
ENSMUSG00000024837
resolver
ensp
ENSMUSP00000025755
resolver
genesymbol
Dmrt1
resolver
uniprot
Q19AV2
resolver
uniprot
Q2TDQ9
resolver
uniprot
Q6Y951
resolver
uniprot
Q6Y953
resolver
uniprot
Q9QZ37
resolver
uniprot
Q9QZA4
resolver
uniprot_entry
DMRT1_MOUSE
resolver
uniprot_sec
Q19AV2
resolver
uniprot_sec
Q2TDQ9
resolver
uniprot_sec
Q6Y951
resolver
uniprot_sec
Q6Y953
resolver
uniprot_sec
Q9QZ37
resolver
uniprot_sec
Q9QZA4
resolver
amino_acid_sequence
MPNDDTFGKPSTPTEVPHAPGAPPQGKAGGYSKAAGAMAGAAGGSGAGGSGGASGSGPSGLGSGSKKSPRLPKCARCRNHGYASPLKGHKRFCMWRDCQCKKCSLIAERQRVMAAQVALRRQQAQEEELGISHPIPLPSAAELLVKRENNASNPCLMAENSSSAQPPPASTPTPAASEGRMVIQDIPAVTSRGHMENTSDLVSDPAYYSSFYQPSLFPYYNNLYNYPQYSMALSAESSSGEVGNSLGGSPVKNSLRSLPAPYVPAQTGNQWQMKTSESRHPVSSQYRMHSYYGPPSYLGQSMSQIFTFEEGPSYSEAKASVFSPPSSQDSGLVSLSSSSPMSNESSKGVLECESASSEPSSYAVNQVLEEDEDE
uniprot
proteins
function
FUNCTION: Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis. {ECO:0000269|PubMed:11040213, ECO:0000269|PubMed:17540358, ECO:0000269|PubMed:20007774, ECO:0000269|PubMed:20616082, ECO:0000269|PubMed:20951351, ECO:0000269|PubMed:21621532, ECO:0000269|PubMed:21775990}.
uniprot
proteins
mass_dalton
39444
uniprot
proteins
protein_family
DMRT family
uniprot
proteins
pubmed
10545231
uniprot
proteins
pubmed
10604464
uniprot
proteins
pubmed
10640721
uniprot
proteins
pubmed
11040213
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17141192
uniprot
proteins
pubmed
17540358
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20007774
uniprot
proteins
pubmed
20616082
uniprot
proteins
pubmed
20951351
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21621532
uniprot
proteins
pubmed
21775990
uniprot
proteins
sequence_length
374
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00070, ECO:0000269|PubMed:11040213}.
uniprot
proteins