GPR15LG
entrez
387695
canonical
uniprot
Q6UWK7
canonical
ensembl
ENSG00000188373
resolver
ensp
ENSP00000361199
resolver
enst
ENST00000372126
resolver
genesymbol
GPR15LG
resolver
genesymbol_syn
C10orf99
resolver
genesymbol_syn
GPR15L
resolver
hgnc
HGNC:31428
resolver
uniprot_entry
GP15L_HUMAN
resolver
amino_acid_sequence
MRLLVLSSLLCILLLCFSIFSTEGKRRPAKAWSGRRTRLCCHRVPSPNSTNLKGHHVRLCKPCKLEPEPRLWVVPGALPQV
uniprot
proteins
function
FUNCTION: Highly cationic protein that has multiple functions. Acts as a chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G protein-coupled receptor GPR15 (PubMed:28900043, PubMed:28936214). May be a tumor suppressor; together with SUSD2 has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). May regulate keratinocyte proliferation (PubMed:29872130). In addition, through activation of Mas-related G protein-coupled receptors (MRGPRs) contributes to pruritogenesis by activating itch-selective sensory neurons and mast cells degranulation (PubMed:35704588). {ECO:0000269|PubMed:25351403, ECO:0000269|PubMed:28900043, ECO:0000269|PubMed:28936214, ECO:0000269|PubMed:29872130, ECO:0000269|PubMed:35704588}.; FUNCTION: Has antimicrobial activity against Gram-positive bacteria, including Staphylococcus aureus and Actinomyces spec., and Mycoplasma hominis and lentivirus (PubMed:25585381). {ECO:0000269|PubMed:25585381}.
uniprot
proteins
mass_dalton
9173
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
25351403
uniprot
proteins
pubmed
25585381
uniprot
proteins
pubmed
28900043
uniprot
proteins
pubmed
28936214
uniprot
proteins
pubmed
29872130
uniprot
proteins
pubmed
35704588
uniprot
proteins
sequence_length
81
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25351403, ECO:0000269|PubMed:25585381}.
uniprot
proteins