IFFO1
entrez
25900
canonical
uniprot
Q0D2I5
canonical
ensembl
ENSG00000010295
resolver
ensp
ENSP00000337593
resolver
ensp
ENSP00000349364
resolver
ensp
ENSP00000380052
resolver
ensp
ENSP00000482285
resolver
ensp
ENSP00000570834
resolver
enst
ENST00000619571
resolver
genesymbol
IFFO1
resolver
genesymbol_syn
IFFO
resolver
hgnc
HGNC:24970
resolver
uniprot
A0A087WZ16
resolver
uniprot
B4DQQ1
resolver
uniprot
Q24JT6
resolver
uniprot
Q6P593
resolver
uniprot
Q7L5J9
resolver
uniprot
Q7Z5X4
resolver
uniprot
Q9BQ46
resolver
uniprot_entry
A0A087WZ16_HUMAN
resolver
uniprot_entry
B4DQQ1_HUMAN
resolver
uniprot_entry
IFFO1_HUMAN
resolver
uniprot_entry
Q6P593_HUMAN
resolver
uniprot_sec
Q24JT6
resolver
uniprot_sec
Q7L5J9
resolver
uniprot_sec
Q7Z5X4
resolver
uniprot_sec
Q9BQ46
resolver
amino_acid_sequence
MNPLFGPNLFLLQQEQQGLAGPLGDSLGGDHFAGGGDLPPAPLSPAGPAAYSPPGPGPAPPAAMALRNDLGSNINVLKTLNLRFRCFLAKVHELERRNRLLEKQLQQALEEGKQGRRGLGRRDQAVQTGFVSPIRPLGLQLGARPAAVCSPSARVLGSPARSPAGPLAPSAASLSSSSTSTSTTYSSSARFMPGTIWSFSHARRLGPGLEPTLVQGPGLSWVHPDGVGVQIDTITPEIRALYNVLAKVKRERDEYKRRWEEEYTVRIQLQDRVNELQEEAQEADACQEELALKVEQLKAELVVFKGLMSNNLSELDTKIQEKAMKVDMDICRRIDITAKLCDVAQQRNCEDMIQMFQVPSMGGRKRERKAAVEEDTSLSESEGPRQPDGDEEESTALSINEEMQRMLNQLREYDFEDDCDSLTWEETEETLLLWEDFSGYAMAAAEAQGEQEDSLEKVIKDTESLFKTREKEYQETIDQIELELATAKNDMNRHLHEYMEMCSMKRGLDVQMETCRRLITQSGDRKSPAFTAVPLSDPPPPPSEAEDSDRDVSSDSSMR
uniprot
proteins
function
FUNCTION: Nuclear matrix protein involved in the immobilization of broken DNA ends and the suppression of chromosome translocation during DNA double-strand breaks (DSBs) (PubMed:31548606). Interacts with the nuclear lamina component LMNA, resulting in the formation of a nucleoskeleton that relocalizes to the DSB sites in a XRCC4-dependent manner and promotes the immobilization of the broken ends, thereby preventing chromosome translocation (PubMed:31548606). Acts as a scaffold that allows the DNA repair protein XRCC4 and LMNA to assemble into a complex at the DSB sites (PubMed:31548606). {ECO:0000269|PubMed:31548606}.
uniprot
proteins
mass_dalton
61979
uniprot
proteins
mutagenesis
MUTAGEN 65; /note="A->P,V: Does not affect the interaction with LMNA."; /evidence="ECO:0000269|PubMed:31548606"; MUTAGEN 73; /note="N->D: Decreased interaction with LMNA. Loss of ability to immobilize broken ends; when associated with H-85."; /evidence="ECO:0000269|PubMed:31548606"; MUTAGEN 73; /note="N->K: Does not affect the interaction with LMNA."; /evidence="ECO:0000269|PubMed:31548606"; MUTAGEN 85; /note="R->H: Decreased interaction with LMNA."; /evidence="ECO:0000269|PubMed:31548606"; MUTAGEN 89; /note="A->T,V: Does not affect the interaction with LMNA."; /evidence="ECO:0000269|PubMed:31548606"; MUTAGEN 480; /note="I->R: Loss of interaction with XRCC4; when associated with R-487."; /evidence="ECO:0000269|PubMed:31548606"; MUTAGEN 487; /note="A->R: Loss of interaction with XRCC4; when associated with R-480."; /evidence="ECO:0000269|PubMed:31548606"; MUTAGEN 490; /note="D->A: Decreased interaction with XRCC4; when associated with A-516. Loss of interaction with XRCC4; when associated with A-509 and A-516."; /evidence="ECO:0000269|PubMed:31548606"; MUTAGEN 509; /note="D->A: Loss of interaction with XRCC4; when associated with A-490 and A-516."; /evidence="ECO:0000269|PubMed:31548606"; MUTAGEN 512; /note="M->R: Loss of interaction with XRCC4."; /evidence="ECO:0000269|PubMed:31548606"; MUTAGEN 515; /note="C->R: Loss of interaction with XRCC4, loss of localization at the sites of DNA damages and loss of ability to immobilize broken ends."; /evidence="ECO:0000269|PubMed:31548606"; MUTAGEN 516; /note="R->A: Decreased interaction with XRCC4; when associated with A-490. Loss of interaction with XRCC4; when associated with A-490 and A-509."; /evidence="ECO:0000269|PubMed:31548606
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
12032826
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
31548606
uniprot
proteins
sequence_length
559
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31548606}. Nucleus, nucleoplasm {ECO:0000269|PubMed:31548606}. Nucleus inner membrane {ECO:0000269|PubMed:31548606}. Nucleus matrix {ECO:0000269|PubMed:31548606}. Note=Mainly soluble, the remaining is localized in the nuclear matrix (PubMed:31548606). Localized at double-strand break (DSB) sites near the lamina and nuclear matrix structures (PubMed:31548606). {ECO:0000269|PubMed:31548606}.
uniprot
proteins