FNBP1L
entrez
54874
canonical
uniprot
Q5T0N5
canonical
ensembl
ENSG00000137942
resolver
ensp
ENSP00000260506
resolver
ensp
ENSP00000271234
resolver
ensp
ENSP00000359275
resolver
genesymbol
FNBP1L
resolver
genesymbol_syn
C1orf39
resolver
genesymbol_syn
TOCA1
resolver
hgnc
HGNC:20851
resolver
uniprot
B4DSI7
resolver
uniprot
J3QSS4
resolver
uniprot
Q5T0N6
resolver
uniprot
Q6B097
resolver
uniprot
Q6P653
resolver
uniprot
Q6R4Q4
resolver
uniprot
Q9NXG1
resolver
uniprot_entry
B4DSI7_HUMAN
resolver
uniprot_entry
FBP1L_HUMAN
resolver
uniprot_sec
J3QSS4
resolver
uniprot_sec
Q5T0N6
resolver
uniprot_sec
Q6B097
resolver
uniprot_sec
Q6P653
resolver
uniprot_sec
Q6R4Q4
resolver
uniprot_sec
Q9NXG1
resolver
amino_acid_sequence
MSWGTELWDQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPKRSSKDEEPRFTSCVAFFNILNELNDYAGQREVVAEEMAHRVYGELMRYAHDLKTERKMHLQEGRKAQQYLDMCWKQMDNSKKKFERECREAEKAQQSYERLDNDTNATKADVEKAKQQLNLRTHMADENKNEYAAQLQNFNGEQHKHFYVVIPQIYKQLQEMDERRTIKLSECYRGFADSERKVIPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFEPPGDFPFEDYSQHIYRTISDGTISASKQESGKMDAKTTVGKAKGKLWLFGKKPKPQSPPLTPTSLFTSSTPNGSQFLTFSIEPVHYCMNEIKTGKPRIPSFRSLKRGWSVKMGPALEDFSHLPPEQRRKKLQQRIDELNRELQKESDQKDALNKMKDVYEKNPQMGDPGSLQPKLAETMNNIDRLRMEIHKNEAWLSEVEGKTGGRGDRRHSSDINHLVTQGRESPEGSYTDDANQEVRGPPQQHGHHNEFDDEFEDDDPLPAIGHCKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARRQNGEEGYVPTSYIDVTLEKNSKGS
uniprot
proteins
function
FUNCTION: Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens. {ECO:0000269|PubMed:15260990, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:19342671}.
uniprot
proteins
mass_dalton
70065
uniprot
proteins
mutagenesis
MUTAGEN 441..443; /note="MGD->IST: Impairs interaction with CDC42 and reduces CDC42-induced actin assembly."; /evidence="ECO:0000269|PubMed:15260990"; MUTAGEN 576; /note="W->K: Impairs interaction with WASL and reduces CDC42-induced actin assembly."; /evidence="ECO:0000269|PubMed:15260990
uniprot
proteins
protein_family
FNBP1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15260990
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16326391
uniprot
proteins
pubmed
16418535
uniprot
proteins
pubmed
16630611
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16757518
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19342671
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19798448
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
605
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16757518}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
uniprot
proteins