COPS7A
entrez
50813
canonical
uniprot
Q9UBW8
canonical
ensembl
ENSG00000111652
resolver
ensp
ENSP00000229251
resolver
ensp
ENSP00000438115
resolver
ensp
ENSP00000438363
resolver
ensp
ENSP00000441852
resolver
ensp
ENSP00000446039
resolver
ensp
ENSP00000559621
resolver
ensp
ENSP00000559622
resolver
ensp
ENSP00000559623
resolver
ensp
ENSP00000559624
resolver
ensp
ENSP00000559626
resolver
ensp
ENSP00000559627
resolver
ensp
ENSP00000559629
resolver
ensp
ENSP00000559632
resolver
ensp
ENSP00000598936
resolver
ensp
ENSP00000598938
resolver
ensp
ENSP00000598942
resolver
ensp
ENSP00000626917
resolver
enst
ENST00000229251
resolver
enst
ENST00000534877
resolver
enst
ENST00000534947
resolver
enst
ENST00000539735
resolver
enst
ENST00000543155
resolver
enst
ENST00000889562
resolver
enst
ENST00000889563
resolver
enst
ENST00000889564
resolver
enst
ENST00000889565
resolver
enst
ENST00000889567
resolver
enst
ENST00000889568
resolver
enst
ENST00000889570
resolver
enst
ENST00000889573
resolver
enst
ENST00000928877
resolver
enst
ENST00000928879
resolver
enst
ENST00000928883
resolver
enst
ENST00000956858
resolver
genesymbol
COPS7A
resolver
genesymbol_syn
CSN7A
resolver
genesymbol_syn
DERP10
resolver
hgnc
HGNC:16758
resolver
uniprot
A8K9A6
resolver
uniprot
Q9NVX3
resolver
uniprot
Q9UJW4
resolver
uniprot_entry
CSN7A_HUMAN
resolver
uniprot_sec
A8K9A6
resolver
uniprot_sec
Q9NVX3
resolver
uniprot_sec
Q9UJW4
resolver
amino_acid_sequence
MSAEVKVTGQNQEQFLLLAKSAKGAALATLIHQVLEAPGVYVFGELLDMPNVRELAESDFASTFRLLTVFAYGTYADYLAEARNLPPLTEAQKNKLRHLSVVTLAAKVKCIPYAVLLEALALRNVRQLEDLVIEAVYADVLRGSLDQRNQRLEVDYSIGRDIQRQDLSAIARTLQEWCVGCEVVLSGIEEQVSRANQHKEQQLGLKQQIESEVANLKKTIKVTTAAAAAATSQDPEQHLTELREPAPGTNQRQPSKKASKGKGLRGSAKIWSKSN
uniprot
proteins
function
FUNCTION: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.
uniprot
proteins
mass_dalton
30277
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CK2 and PKD kinases. {ECO:0000269|PubMed:12628923}.
uniprot
proteins
protein_family
CSN7 subfamily
uniprot
proteins
protein_family
CSN7/EIF3M family
uniprot
proteins
pubmed
11285227
uniprot
proteins
pubmed
11337588
uniprot
proteins
pubmed
12020345
uniprot
proteins
pubmed
12220626
uniprot
proteins
pubmed
12628923
uniprot
proteins
pubmed
12732143
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18850735
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26456823
uniprot
proteins
pubmed
29444943
uniprot
proteins
pubmed
9535219
uniprot
proteins
sequence_length
275
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}.
uniprot
proteins