MIEN1
entrez
84299
canonical
uniprot
Q9BRT3
canonical
ensembl
ENSG00000141741
resolver
ensp
ENSP00000377778
resolver
ensp
ENSP00000462998
resolver
enst
ENST00000394231
resolver
enst
ENST00000577810
resolver
genesymbol
MIEN1
resolver
genesymbol_syn
C17orf37
resolver
genesymbol_syn
RDX12
resolver
genesymbol_syn
XTP4
resolver
hgnc
HGNC:28230
resolver
uniprot
J3KTI2
resolver
uniprot_entry
J3KTI2_HUMAN
resolver
uniprot_entry
MIEN1_HUMAN
resolver
amino_acid_sequence
MSGEPGQTSVAPPPEEVEPGSGVRIVVEYCEPCGFEATYLELASAVKEQYPGIEIESRLGGTGAFEIEINGQLVFSKLENGGFPYEKDLIEAIRRASNGETLEKITNSRPPCVIL
uniprot
proteins
function
FUNCTION: Increases cell migration by inducing filopodia formation at the leading edge of migrating cells. Plays a role in regulation of apoptosis, possibly through control of CASP3. May be involved in a redox-related process. {ECO:0000269|PubMed:19503095, ECO:0000269|PubMed:21628459}.
uniprot
proteins
mass_dalton
12403
uniprot
proteins
mutagenesis
MUTAGEN 112..115; /note="Missing: No effect on subcellular location. Low protein abundance, suggesting that stability is affected."; /evidence="ECO:0000269|PubMed:21628459"; MUTAGEN 112; /note="C->S: Abolishes prenylation. Predominantly cytosolic with little plasma membrane-associated expression. Reduces cell migration by affecting filopodia formation."; /evidence="ECO:0000269|PubMed:21628459
uniprot
proteins
post_translational_modification
PTM: Isoprenylation facilitates association with the plasma membrane and enhances the migratory phenotype of cells by inducing increased filopodia formation. {ECO:0000269|PubMed:17121940, ECO:0000269|PubMed:19503095, ECO:0000269|PubMed:21628459}.
uniprot
proteins
protein_family
SelWTH family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17121940
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19503095
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21628459
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23284973
uniprot
proteins
sequence_length
115
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cell membrane; Lipid-anchor; Cytoplasmic side. Note=Concentrates at the leading edge of migrating cells. Localizes outside membrane raft regions.
uniprot
proteins