Asip
entrez
50518
canonical
uniprot
Q03288
canonical
ensembl
ENSMUSG00000027596
resolver
ensp
ENSMUSP00000029123
resolver
ensp
ENSMUSP00000105319
resolver
enst
ENSMUST00000029123
resolver
enst
ENSMUST00000109697
resolver
genesymbol
Asip
resolver
genesymbol
Gm14226
resolver
genesymbol_syn
a
resolver
uniprot
A2ALT3
resolver
uniprot
Q3TZL0
resolver
uniprot
Q80ST0
resolver
uniprot_entry
ASIP_MOUSE
resolver
uniprot_entry
Q3TZL0_MOUSE
resolver
uniprot_sec
A2ALT3
resolver
uniprot_sec
Q80ST0
resolver
amino_acid_sequence
MDVTRLLLATLVGFLCFFTVHSHLALEETLGDDRSLRSNSSMNSLDFSSVSIVALNKKSKKISRKEAEKRKRSSKKKASMKKVARPPPPSPCVATRDSCKPPAPACCDPCASCQCRFFGSACTCRVLNPNC
uniprot
proteins
function
FUNCTION: Signaling protein that functions as an antagonist of melanocyte-stimulating-hormone receptor MC1R, thereby playing a role in the regulation of melanogenesis (PubMed:7935841). Binding to MC1R prevents alpha-MSH-induced signaling and inhibits cAMP production, resulting in down-regulation of eumelanogenesis (brown/black pigment) and increased pheomelanin (yellow/red pigment) synthesis (PubMed:7935841, PubMed:8449404). {ECO:0000269|PubMed:7935841, ECO:0000269|PubMed:8449404}.
uniprot
proteins
mass_dalton
14313
uniprot
proteins
pubmed
1473152
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
7935841
uniprot
proteins
pubmed
7987393
uniprot
proteins
pubmed
8202545
uniprot
proteins
pubmed
8319910
uniprot
proteins
pubmed
8449404
uniprot
proteins
sequence_length
131
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8449404}.
uniprot
proteins