Dhx58
entrez
80861
canonical
uniprot
Q99J87
canonical
ensembl
ENSMUSG00000017830
resolver
ensp
ENSMUSP00000017974
resolver
enst
ENSMUST00000017974
resolver
genesymbol
Dhx58
resolver
genesymbol_syn
D11lgp2e
resolver
genesymbol_syn
Lgp2
resolver
uniprot
A2A5E9
resolver
uniprot
Q9D1X4
resolver
uniprot_entry
DHX58_MOUSE
resolver
uniprot_sec
A2A5E9
resolver
uniprot_sec
Q9D1X4
resolver
amino_acid_sequence
MELRPYQWEVILPALEGKNIIIWLPTGAGKTRAAAFVAKRHLETVDRGKVVVLVNRVHLVSQHAEEFRRMLDKHWTVTTLSGDMGSRAGFGLMARSHDLLICTAELLQLALNSSEEDEHVELREFSLIVVDECHHTHKDTVYNTILSRYLEQKLKKAEPLPQVLGLTASPGTGGATKLQGAIDHILQLCANLDTCHIMSPKNCYSQLLMHNPKPCKQYDLCQRRAQDPFGDLIKKLMNQIHQQLEMPDLKQQFGTQMYEQQVVQLCKDAAEAGLQEQRVYALHLRRYNDALFIHDTVRARDALDMLQDFYDRERTTKTQMVRAESWLLKLFDDHKNVLGQLAARGPENPKLEMLERILLKQFGSPGHTRGIIFTRTRQTASSLLLWLRQQPCLQTVGIKPQMLIGAGNTSQSTHMTQKDQQEVIQEFRDGILSLLVATSVAEEGLDIAQCNVVVRYGLLTNEISMVQARGRARAGQSVYSFLATEGSREMKRELTNEALEVLMEKAVAAVQKMDPDEFKAKIRDLQQASLVKRAARAAHREIQQGQFLPEHVQLLCINCMVAVGYGSDLRKVEGTHHVNVNPNFSVYYTTSQNPVVINKVFKDWRPGGTIRCSNCGEVWGFQMIYKSVTLPVLKIGSILLETPRGKIQAKKWSRVPFSIPVFDILQDCTQSLSELSLD
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: Acts as a regulator of RIGI and IFIH1/MDA5 mediated antiviral signaling. Cannot initiate antiviral signaling as it lacks the CARD domain required for activating MAVS/IPS1-dependent signaling events. Can have both negative and positive regulatory functions related to RIGI and IFIH1/MDA5 signaling and this role in regulating signaling may be complex and could probably depend on characteristics of the infecting virus or target cells, or both. Its inhibitory action on RIG-I signaling may involve the following mechanisms: competition with RIGI for binding to the viral RNA, binding to RIGI and inhibiting its dimerization and interaction with MAVS/IPS1, competing with IKBKE in its binding to MAVS/IPS1 thereby inhibiting activation of interferon regulatory factor 3 (IRF3). Its positive regulatory role may involve unwinding or stripping nucleoproteins of viral RNA thereby facilitating their recognition by RIGI and IFIH1/MDA5. Involved in the innate immune response to various RNA viruses and some DNA viruses such as poxviruses, and also to the bacterial pathogen Listeria monocytogenes. Can bind both ssRNA and dsRNA, with a higher affinity for dsRNA. Shows a preference to 5'-triphosphorylated RNA, although it can recognize RNA lacking a 5'-triphosphate. {ECO:0000269|PubMed:17475874, ECO:0000269|PubMed:20080593, ECO:0000269|PubMed:21525357, ECO:0000269|PubMed:21533147}.
uniprot
proteins
mass_dalton
76709
uniprot
proteins
mutagenesis
MUTAGEN 30; /note="K->A: Abolishes IFNB1 production upon infection with various viruses."; /evidence="ECO:0000269|PubMed:20080593
uniprot
proteins
protein_family
Helicase family
uniprot
proteins
protein_family
RLR subfamily
uniprot
proteins
pubmed
11161808
uniprot
proteins
pubmed
11735219
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17473309
uniprot
proteins
pubmed
17475874
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20080593
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21481967
uniprot
proteins
pubmed
21496944
uniprot
proteins
pubmed
21525357
uniprot
proteins
pubmed
21533147
uniprot
proteins
pubmed
21616437
uniprot
proteins
sequence_length
678
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11735219}.
uniprot
proteins