COMMD6
entrez
170622
canonical
uniprot
Q7Z4G1
canonical
ensembl
ENSG00000188243
resolver
ensp
ENSP00000348054
resolver
ensp
ENSP00000506987
resolver
genesymbol
COMMD6
resolver
hgnc
HGNC:24015
resolver
uniprot
A6NF28
resolver
uniprot
B7ZLN0
resolver
uniprot
Q5TBK4
resolver
uniprot_entry
COMD6_HUMAN
resolver
uniprot_sec
A6NF28
resolver
uniprot_sec
B7ZLN0
resolver
uniprot_sec
Q5TBK4
resolver
amino_acid_sequence
MEASSEPPLDAKSDVTNQLVDFQWKLGMAVSSDTCRSLKYPYVAVMLKVADHSGQVKTKCFEMTIPQFQNFYRQFKEIAAVIETV
uniprot
proteins
function
FUNCTION: Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B (PubMed:15799966, PubMed:16573520). Inhibits TNF-induced NFKB1 activation (PubMed:15799966, PubMed:16573520). {ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:16573520, ECO:0000269|PubMed:37172566, ECO:0000269|PubMed:38459129, ECO:0000305|PubMed:21778237}.
uniprot
proteins
mass_dalton
9638
uniprot
proteins
mutagenesis
MUTAGEN 24; /note="W->A: Does not abolish homodimerization and interaction with COMMD1. Does not abolish repression of TNF-induced NFKB1 activation. Abolishes repression of TNF-induced NFKB1 activation; when associated with A-41."; /evidence="ECO:0000269|PubMed:16573520"; MUTAGEN 41; /note="P->A: Does not abolish homodimerization and interaction with COMMD1. Does not abolish repression of TNF-induced NFKB1 activation. Abolishes repression of TNF-induced NFKB1 activation; when associated with A-24."; /evidence="ECO:0000269|PubMed:16573520
uniprot
proteins
protein_family
COMM domain-containing protein 6 family
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15799966
uniprot
proteins
pubmed
16573520
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21778237
uniprot
proteins
pubmed
23563313
uniprot
proteins
pubmed
23637203
uniprot
proteins
pubmed
25355947
uniprot
proteins
pubmed
37172566
uniprot
proteins
pubmed
38459129
uniprot
proteins
pubmed
38504028
uniprot
proteins
sequence_length
85
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16573520, ECO:0000269|PubMed:21778237}. Cytoplasm {ECO:0000269|PubMed:16573520}.
uniprot
proteins