Dpagt1
entrez
13478
canonical
uniprot
P42867
canonical
ensembl
ENSMUSG00000032123
resolver
ensp
ENSMUSP00000056282
resolver
enst
ENSMUST00000054708
resolver
genesymbol
Dpagt1
resolver
genesymbol_syn
Dpagt2
resolver
genesymbol_syn
Gnpta
resolver
uniprot
Q921W5
resolver
uniprot
Q9CPT1
resolver
uniprot_entry
GPT_MOUSE
resolver
uniprot_entry
Q9CPT1_MOUSE
resolver
uniprot_sec
Q921W5
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by natural nucleoside antibiotic tunicamycin, which acts as a structural analog and competitor of UDP-GlcNAc. {ECO:0000250|UniProtKB:P23338}.
uniprot
proteins
amino_acid_sequence
MWAFPELPLPLPLLVNLIGSLLGFVATVTLIPAFRSHFIAARLCGQDLNKLSQQQIPESQGVISGAVFLIILFCFIPFPFLNCFVEEQCKAFPHHEFVALIGALLAICCMIFLGFADDVLNLRWRHKLLLPTAASLPLLMVYFTNFGNTTIVVPKPFRWILGLHLDLGILYYVYMGLLAVFCTNAINILAGINGLEAGQSLVISASIIVFNLVELEGDYRDDHIFSLYFMIPFFFTTLGLLYHNWYPSRVFVGDTFCYFAGMTFAVVGILGHFSKTMLLFFMPQVFNFLYSLPQLFHIIPCPRHRMPRLNAKTGKLEMSYSKFKTKNLSFLGTFILKVAENLRLVTVHQGESEDGAFTECNNMTLINLLLKVFGPIHERNLTLLLLLLQVLSSAATFSIRYQLVRLFYDV
uniprot
proteins
ec_number
2.7.8.15
uniprot
proteins
function
FUNCTION: UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transferring GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane. {ECO:0000250|UniProtKB:Q9H3H5}.
uniprot
proteins
mass_dalton
46412
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:Q9H3H5}.
uniprot
proteins
protein_family
Glycosyltransferase 4 family
uniprot
proteins
pubmed
10536042
uniprot
proteins
pubmed
1323278
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8043075
uniprot
proteins
sequence_length
410
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P23338}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9H3H5}.
uniprot
proteins
transmembrane_region
TRANSMEM 11..40; /note="Helical; Name=Helix 1"; /evidence="ECO:0000250|UniProtKB:Q9H3H5"; TRANSMEM 61..80; /note="Helical; Name=Helix 2"; /evidence="ECO:0000250|UniProtKB:Q9H3H5"; TRANSMEM 94..120; /note="Helical; Name=Helix 3"; /evidence="ECO:0000250|UniProtKB:Q9H3H5"; TRANSMEM 124..145; /note="Helical; Name=Helix 4"; /evidence="ECO:0000250|UniProtKB:Q9H3H5"; TRANSMEM 169..188; /note="Helical; Name=Helix 5"; /evidence="ECO:0000250|UniProtKB:Q9H3H5"; TRANSMEM 195..215; /note="Helical; Name=Helix 6"; /evidence="ECO:0000250|UniProtKB:Q9H3H5"; TRANSMEM 221..244; /note="Helical; Name=Helix 7"; /evidence="ECO:0000250|UniProtKB:Q9H3H5"; TRANSMEM 253..271; /note="Helical; Name=Helix 8"; /evidence="ECO:0000250|UniProtKB:Q9H3H5"; TRANSMEM 274..295; /note="Helical; Name=Helix 9"; /evidence="ECO:0000250|UniProtKB:Q9H3H5"; TRANSMEM 378..402; /note="Helical; Name=Helix 10"; /evidence="ECO:0000250|UniProtKB:Q9H3H5
uniprot
proteins