Cenpq
entrez
363198
canonical
uniprot
Q66H02
canonical
ensembl
ENSRNOG00000056226
resolver
ensp
ENSRNOP00000072803
resolver
ensp
ENSRNOP00000084774
resolver
enst
ENSRNOT00000104636
resolver
genesymbol
Cenpq
resolver
genesymbol_syn
AABR07066944.1
resolver
uniprot
A0A8I5ZZW1
resolver
uniprot_entry
A0A8I5ZZW1_RAT
resolver
uniprot_entry
CENPQ_RAT
resolver
amino_acid_sequence
MSGKANTSKKKSQRVKRNVKQRADKEDEELDSPENKVGNRAKRNRSHAGHLSSKEQTKCVHLKRVKISSNKRTAWQPLPKNTEEYLQSMMDSAILGILNKNIKRKEQIQYHLDQLKKRFLQQCATLKVPPGKLNYLRDMSKLLKVEREQERANEESLASLQEEIDKIVETTESMTENIESLKTKIEILTNEVEKEEEEMKEVFHIDSNKVLALPELSQKSLKAPILQKEILTLIPNQNALLKDLDVLQNSAPGKNMAAFIQEAYMKLNGS
uniprot
proteins
function
FUNCTION: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores. {ECO:0000250|UniProtKB:Q7L2Z9}.
uniprot
proteins
mass_dalton
31002
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-52 is essential for CENPE recruitment to kinetochores and orderly chromosome congression. {ECO:0000250|UniProtKB:Q7L2Z9}.
uniprot
proteins
protein_family
CENP-Q/OKP1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
270
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7L2Z9}. Chromosome, centromere {ECO:0000250|UniProtKB:Q7L2Z9}. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex. {ECO:0000250|UniProtKB:Q7L2Z9}.
uniprot
proteins