Brme1
entrez
74666
canonical
uniprot
Q6DIA7
canonical
ensembl
ENSMUSG00000008129
resolver
ensp
ENSMUSP00000091067
resolver
ensp
ENSMUSP00000113651
resolver
genesymbol
Brme1
resolver
genesymbol_syn
Meiok21
resolver
uniprot
A0A0R4J144
resolver
uniprot
E9QNR8
resolver
uniprot
Q9D5J2
resolver
uniprot_entry
BRME1_MOUSE
resolver
uniprot_sec
A0A0R4J144
resolver
uniprot_sec
E9QNR8
resolver
uniprot_sec
Q9D5J2
resolver
amino_acid_sequence
MNKKKQRNSGVGLHPSKPSKNPRLRDSQSSMMVHSHYSRESEDSSEPAPSVELGGEEPLHEAFSCPVEDTGAASDLAGSPKELVPLPPSQNSVGKFVPQFAKPRKTVTRKAKAWEEDLEGCTTSQETRPELGALKAASQPQRESLRFPPHDIRPEVQTQPDGTLSKERTISLDNRSLGNNGFEMATVQDSSSPLSDAAAEGREADSRDPQERDAQGGEAGAQHSGEPQEGEDILYTSALAPASEPTWSVAQDLSVPTYTLSSTAAAPSSTSPADASLMDTVITEVSLDPSVLQQSAPQVAKLLGSLDEQIPDGGCIGTLLSSTPLAEETTAGREEARWEERCHGDTLASFTETEPEKQEPVTEAGDSGHIAQEMDPVVKTKDSGSDEQSPGDIGMLPLPAQSMNQMLVELRGLTCDQDLEGLSTPHTSSQLEHTCAASDPPQSTKDCHSSPGIPVHLAAPCPRDQAAWQESSAMELDFLPDSQIQDALDATNMEQGFPSGSMPDLGWPVPSSQSIGGSPKAVTKPQSRSHVETWAQETYRMQDATDTVRGLVVELSGLNRLIMSTHRDLEAFKRRKTKSLPYLTKGLGSLPRGDQSWRDL
uniprot
proteins
function
FUNCTION: Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair (PubMed:32460033, PubMed:32463460). Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with and stabilization of the BRCA2:HSF2BP complex during meiotic recombination (PubMed:32460033, PubMed:32463460). Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility (PubMed:32460033, PubMed:32463460). {ECO:0000269|PubMed:32460033, ECO:0000269|PubMed:32463460, ECO:0000269|PubMed:32845237}.
uniprot
proteins
mass_dalton
64440
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32345962
uniprot
proteins
pubmed
32460033
uniprot
proteins
pubmed
32463460
uniprot
proteins
pubmed
32845237
uniprot
proteins
sequence_length
600
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:32345962, ECO:0000269|PubMed:32460033, ECO:0000269|PubMed:32463460, ECO:0000269|PubMed:32845237}. Note=During meiosis, recruited to chromosomes and localizes on recombination sites in a double-strand break-dependent manner. First appears on the chromosome axis at leptotene. Along with the progression of meiotic recombination, released from the axis to form bridge-like structures linking homolog axes before they are synapsed. Finally, located between synapsed homolog axes and on the synaptonemal complex (SC). {ECO:0000269|PubMed:32345962, ECO:0000269|PubMed:32460033, ECO:0000269|PubMed:32463460, ECO:0000269|PubMed:32845237}.
uniprot
proteins