RNF212
entrez
285498
canonical
uniprot
Q495C1
canonical
ensembl
ENSG00000178222
resolver
ensp
ENSP00000327481
resolver
ensp
ENSP00000372428
resolver
ensp
ENSP00000389709
resolver
ensp
ENSP00000513634
resolver
ensp
ENSP00000719556
resolver
ensp
ENSP00000762474
resolver
ensp
ENSP00000777368
resolver
enst
ENST00000698262
resolver
genesymbol
RNF212
resolver
hgnc
HGNC:27729
resolver
uniprot
A0A8V8TN20
resolver
uniprot
C9J8N0
resolver
uniprot
Q495C0
resolver
uniprot
Q86W82
resolver
uniprot
Q8IY99
resolver
uniprot
Q8N8U7
resolver
uniprot_entry
A0A8V8TN20_HUMAN
resolver
uniprot_entry
RN212_HUMAN
resolver
uniprot_sec
C9J8N0
resolver
uniprot_sec
Q495C0
resolver
uniprot_sec
Q86W82
resolver
uniprot_sec
Q8IY99
resolver
uniprot_sec
Q8N8U7
resolver
amino_acid_sequence
MANWVFCNRCFQPPHRTSCFSLTNCGHVYCDACLGKGKKNECLICKAPCRTVLLSKHTDADIQAFFMSIDSLCKKYSRETSQILEFQEKHRKRLLAFYREKISRLEESLRKSVLQIEQLQSMRSSQQTAFSTIKSSVSTKPHGCLLPPHSSAPDRLESMEVDLSPSPIRKSEIAAGPARISMISPPQDGRMGPHLTASFCFIPWLTLSKPPVPGECVISRGSPCFCIDVCPHWLLLLAFSSGRHGELTNSKTLPIYAEVQRAVLFPFQQAEGTLDTFRTPAVSVVFPLCQFERKKSF
uniprot
proteins
disease_involvement
DISEASE: Spermatogenic failure 62 (SPGF62) [MIM:619673]: An autosomal recessive male infertility disorder characterized by non-obstructive azoospermia, due to complete metaphase arrest at the spermatocyte stage. {ECO:0000269|PubMed:31125047}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.3.2.-
uniprot
proteins
function
FUNCTION: SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
33365
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein sumoylation.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18239089
uniprot
proteins
pubmed
31125047
uniprot
proteins
sequence_length
297
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Associates to the synaptonemal complex. Localizes to a minority of double-strand breaks (DSBs) sites. Marks crossover sites during midpachynema (By similarity). {ECO:0000250}.
uniprot
proteins