SOAT1
entrez
6646
canonical
uniprot
P35610
canonical
ensembl
ENSG00000057252
resolver
ensp
ENSP00000356591
resolver
ensp
ENSP00000441356
resolver
ensp
ENSP00000445315
resolver
ensp
ENSP00000707828
resolver
genesymbol
SOAT1
resolver
genesymbol_syn
ACACT
resolver
genesymbol_syn
ACACT1
resolver
genesymbol_syn
ACAT
resolver
genesymbol_syn
ACAT1
resolver
genesymbol_syn
SOAT
resolver
genesymbol_syn
STAT
resolver
hgnc
HGNC:11177
resolver
uniprot
A6NC40
resolver
uniprot
A8K3P4
resolver
uniprot
A9Z1V7
resolver
uniprot
B4DU95
resolver
uniprot
Q5T0X4
resolver
uniprot
Q8N1E4
resolver
uniprot_entry
SOAT1_HUMAN
resolver
uniprot_sec
A6NC40
resolver
uniprot_sec
A8K3P4
resolver
uniprot_sec
A9Z1V7
resolver
uniprot_sec
B4DU95
resolver
uniprot_sec
Q5T0X4
resolver
uniprot_sec
Q8N1E4
resolver
activity_regulation
ACTIVITY REGULATION: Cholesterol O-acyltransferase activity is inhibited by nevanimibe. {ECO:0000269|PubMed:32433613}.
uniprot
proteins
amino_acid_sequence
MVGEEKMSLRNRLSKSRENPEEDEDQRNPAKESLETPSNGRIDIKQLIAKKIKLTAEAEELKPFFMKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSVLEGEKNNHRAKDLRAPPEQGKIFIARRSLLDELLEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFSLLSYAFGKFPTVVWTWWIMFLSTFSVPYFLFQHWATGYSKSSHPLIRSLFHGFLFMIFQIGVLGFGPTYVVLAYTLPPASRFIIIFEQIRFVMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRNPTVRWGYVAMKFAQVFGCFFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLILFLTFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYAYKDFLWFFSKRFKSAAMLAVFAVSAVVHEYALAVCLSFFYPVLFVLFMFFGMAFNFIVNDSRKKPIWNVLMWTSLFLGNGVLLCFYSQEWYARQHCPLKNPTFLDYVRPRSWTCRYVF
uniprot
proteins
ec_number
2.3.1.26
uniprot
proteins
function
FUNCTION: Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol (PubMed:16154994, PubMed:16647063, PubMed:32433613, PubMed:32433614, PubMed:32944968, PubMed:9020103). Plays a role in lipoprotein assembly and dietary cholesterol absorption (PubMed:16154994, PubMed:9020103). Preferentially utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) as a substrate: shows a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions (PubMed:11294643, PubMed:32433614). {ECO:0000269|PubMed:11294643, ECO:0000269|PubMed:16154994, ECO:0000269|PubMed:16647063, ECO:0000269|PubMed:32433613, ECO:0000269|PubMed:32433614, ECO:0000269|PubMed:32944968, ECO:0000269|PubMed:9020103}.
uniprot
proteins
mass_dalton
64735
uniprot
proteins
mutagenesis
MUTAGEN 262; /note="R->A: Strongly reduced cholesterol O-acyltransferase activity."; /evidence="ECO:0000269|PubMed:32433614"; MUTAGEN 263; /note="F->A: Strongly reduced cholesterol O-acyltransferase activity."; /evidence="ECO:0000269|PubMed:32433614"; MUTAGEN 269; /note="S->A,T: Nearly normal expression and enzyme activity."; /evidence="ECO:0000269|PubMed:16154994"; MUTAGEN 269; /note="S->L: No expression nor activity."; /evidence="ECO:0000269|PubMed:16154994"; MUTAGEN 306; /note="L->N: Strongly reduced cholesterol O-acyltransferase activity."; /evidence="ECO:0000269|PubMed:32433614"; MUTAGEN 367; /note="F->A: Abolished homodimerization; when associated with 504-A--A-508."; /evidence="ECO:0000269|PubMed:32433614"; MUTAGEN 386; /note="H->A: Abolished cholesterol O-acyltransferase activity."; /evidence="ECO:0000269|PubMed:16647063"; MUTAGEN 400; /note="D->N: Low expression, loss of enzymatic activity."; /evidence="ECO:0000269|PubMed:18480028"; MUTAGEN 407; /note="W->A: Almost abolished cholesterol O-acyltransferase activity."; /evidence="ECO:0000269|PubMed:32433614"; MUTAGEN 415; /note="N->G: Reduced cholesterol O-acyltransferase activity."; /evidence="ECO:0000269|PubMed:32433614"; MUTAGEN 418; /note="R->A: Reduced cholesterol O-acyltransferase activity."; /evidence="ECO:0000269|PubMed:32433613"; MUTAGEN 420; /note="W->A: Almost abolished cholesterol O-acyltransferase activity."; /evidence="ECO:0000269|PubMed:32433614"; MUTAGEN 421; /note="N->A: Almost abolished cholesterol O-acyltransferase activity."; /evidence="ECO:0000269|PubMed:32433613, ECO:0000269|PubMed:32433614"; MUTAGEN 425; /note="H->A: Strongly reduced cholesterol O-acyltransferase activity."; /evidence="ECO:0000269|PubMed:32433613, ECO:0000269|PubMed:32433614"; MUTAGEN 428; /note="L->Q: Almost abolished cholesterol O-acyltransferase activity."; /evidence="ECO:0000269|PubMed:32433614"; MUTAGEN 429; /note="Y->A: Strongly reduced cholesterol O-acyltransferase activity."; /evidence="ECO:0000269|PubMed:32433614"; MUTAGEN 445; /note="K->A: Reduced cholesterol O-acyltransferase activity."; /evidence="ECO:0000269|PubMed:32433613, ECO:0000269|PubMed:32433614"; MUTAGEN 452..456; /note="VFAVS->QFAVQ: In QQ mutant; almost abolished cholesterol O-acyltransferase activity."; /evidence="ECO:0000269|PubMed:32433614"; MUTAGEN 452..453; /note="VF->AA: Almost abolished cholesterol O-acyltransferase activity."; /evidence="ECO:0000269|PubMed:32433614"; MUTAGEN 456; /note="S->A: Abolished cholesterol O-acyltransferase activity."; /evidence="ECO:0000269|PubMed:18480028, ECO:0000269|PubMed:32433614"; MUTAGEN 460; /note="H->A,C,N: Abolished cholesterol O-acyltransferase activity."; /evidence="ECO:0000269|PubMed:16154994, ECO:0000269|PubMed:16647063, ECO:0000269|PubMed:32433613, ECO:0000269|PubMed:32433614"; MUTAGEN 504..508; /note="WTSLF->ATSLA: Abolished homodimerization; when associated with A-367."; /evidence="ECO:0000269|PubMed:32433614"; MUTAGEN 507; /note="L->A: Strongly reduced cholesterol O-acyltransferase activity."; /evidence="ECO:0000269|PubMed:32433614"; MUTAGEN 518; /note="Y->F: Loss of enzymatic activity."; /evidence="ECO:0000269|PubMed:18480028
uniprot
proteins
protein_family
Membrane-bound acyltransferase family
uniprot
proteins
protein_family
Sterol o-acyltransferase subfamily
uniprot
proteins
pubmed
10438503
uniprot
proteins
pubmed
11294643
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16154994
uniprot
proteins
pubmed
16647063
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18480028
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23169578
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
32433613
uniprot
proteins
pubmed
32433614
uniprot
proteins
pubmed
32944968
uniprot
proteins
pubmed
8407899
uniprot
proteins
pubmed
9020103
uniprot
proteins
sequence_length
550
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10438503, ECO:0000269|PubMed:16154994}; Multi-pass membrane protein {ECO:0000269|PubMed:32433613, ECO:0000269|PubMed:32433614}.
uniprot
proteins
transmembrane_region
TRANSMEM 139..160; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:32433614, ECO:0000305|PubMed:32433613, ECO:0007744|PDB:6P2J, ECO:0007744|PDB:6P2P, ECO:0007744|PDB:6VUM"; TRANSMEM 181..206; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:32433614, ECO:0000305|PubMed:32433613, ECO:0007744|PDB:6P2J, ECO:0007744|PDB:6P2P, ECO:0007744|PDB:6VUM"; TRANSMEM 219..244; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:32433614, ECO:0000305|PubMed:32433613, ECO:0007744|PDB:6P2J, ECO:0007744|PDB:6P2P, ECO:0007744|PDB:6VUM"; TRANSMEM 253..276; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:32433614, ECO:0000305|PubMed:32433613, ECO:0007744|PDB:6P2J, ECO:0007744|PDB:6P2P, ECO:0007744|PDB:6VUM"; TRANSMEM 320..352; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:32433614, ECO:0000305|PubMed:32433613, ECO:0007744|PDB:6P2J, ECO:0007744|PDB:6P2P, ECO:0007744|PDB:6VUM"; TRANSMEM 370..395; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:32433614, ECO:0000305|PubMed:32433613, ECO:0007744|PDB:6P2J, ECO:0007744|PDB:6P2P, ECO:0007744|PDB:6VUM"; TRANSMEM 444..468; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:32433614, ECO:0000305|PubMed:32433613, ECO:0007744|PDB:6P2J, ECO:0007744|PDB:6P2P, ECO:0007744|PDB:6VUM"; TRANSMEM 475..490; /note="Helical; Name=8"; /evidence="ECO:0000269|PubMed:32433614, ECO:0000305|PubMed:32433613, ECO:0007744|PDB:6P2J, ECO:0007744|PDB:6P2P, ECO:0007744|PDB:6VUM"; TRANSMEM 497..528; /note="Helical; Name=9"; /evidence="ECO:0000269|PubMed:32433613, ECO:0000269|PubMed:32433614, ECO:0007744|PDB:6P2J, ECO:0007744|PDB:6P2P, ECO:0007744|PDB:6VUM
uniprot
proteins