Tpm2
entrez
500450
canonical
uniprot
P58775
canonical
ensembl
ENSRNOG00000016731
resolver
ensembl
ENSRNOG00055016972
resolver
ensembl
ENSRNOG00060003924
resolver
ensembl
ENSRNOG00065009935
resolver
ensp
ENSRNOP00000022801
resolver
ensp
ENSRNOP00000044473
resolver
ensp
ENSRNOP00000080861
resolver
genesymbol
Tpm2
resolver
genesymbol_syn
MGC109519
resolver
uniprot
P02560
resolver
uniprot
P06395
resolver
uniprot
Q5FVG5
resolver
uniprot_entry
Q5FVG5_RAT
resolver
uniprot_entry
TPM2_RAT
resolver
uniprot_sec
P02560
resolver
uniprot_sec
P06395
resolver
amino_acid_sequence
MDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESVKDAQEKLEQAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLVILEGELERSEERAEVAESKCGDLEEELKIVTNNLKSLEAQADKYSTKEDKYEEEIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEDEVYAQKMKYKAISEELDNALNDITSL
uniprot
proteins
function
FUNCTION: Binds to actin filaments in muscle and non-muscle cells (PubMed:22812662, PubMed:7568216). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:22812662). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization (By similarity). {ECO:0000250|UniProtKB:P58774, ECO:0000269|PubMed:22812662, ECO:0000269|PubMed:7568216}.
uniprot
proteins
mass_dalton
32837
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser-61 by PIK3CG. Phosphorylation on Ser-61 is required for ADRB2 internalization (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Tropomyosin family
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
22812662
uniprot
proteins
pubmed
2432392
uniprot
proteins
pubmed
3840484
uniprot
proteins
pubmed
7568216
uniprot
proteins
sequence_length
284
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:7568216}. Note=Associates with F-actin stress fibers (PubMed:7568216). {ECO:0000269|PubMed:7568216}.
uniprot
proteins