CD55
entrez
1604
canonical
uniprot
P08174
canonical
ensembl
ENSG00000196352
resolver
ensp
ENSP00000316333
resolver
ensp
ENSP00000356030
resolver
ensp
ENSP00000356031
resolver
ensp
ENSP00000495518
resolver
ensp
ENSP00000496251
resolver
enst
ENST00000367063
resolver
genesymbol
CD55
resolver
genesymbol_syn
CR
resolver
genesymbol_syn
DAF
resolver
hgnc
HGNC:2665
resolver
uniprot
B1AP13
resolver
uniprot
B1AP14
resolver
uniprot
D3DT83
resolver
uniprot
D3DT84
resolver
uniprot
E7ER69
resolver
uniprot
P09679
resolver
uniprot
P78361
resolver
uniprot
Q14UF2
resolver
uniprot
Q14UF3
resolver
uniprot
Q14UF4
resolver
uniprot
Q14UF5
resolver
uniprot
Q14UF6
resolver
uniprot_entry
B1AP13_HUMAN
resolver
uniprot_entry
DAF_HUMAN
resolver
uniprot_sec
B1AP14
resolver
uniprot_sec
D3DT83
resolver
uniprot_sec
D3DT84
resolver
uniprot_sec
E7ER69
resolver
uniprot_sec
P09679
resolver
uniprot_sec
P78361
resolver
uniprot_sec
Q14UF2
resolver
uniprot_sec
Q14UF3
resolver
uniprot_sec
Q14UF4
resolver
uniprot_sec
Q14UF5
resolver
uniprot_sec
Q14UF6
resolver
amino_acid_sequence
MTVARPSVPAALPLLGELPRLLLLVLLCLPAVWGDCGLPPDVPNAQPALEGRTSFPEDTVITYKCEESFVKIPGEKDSVICLKGSQWSDIEEFCNRSCEVPTRLNSASLKQPYITQNYFPVGTVVEYECRPGYRREPSLSPKLTCLQNLKWSTAVEFCKKKSCPNPGEIRNGQIDVPGGILFGATISFSCNTGYKLFGSTSSFCLISGSSVQWSDPLPECREIYCPAPPQIDNGIIQGERDHYGYRQSVTYACNKGFTMIGEHSIYCTVNNDEGEWSGPPPECRGKSLTSKVPPTVQKPTTVNVPTTEVSPTSQKTTTKTTTPNAQATRSTPVSRTTKHFHETTPNKGSGTTSGTTRLLSGHTCFTLTGLLGTLVTMGLLT
uniprot
proteins
disease_involvement
DISEASE: Complement hyperactivation, angiopathic thrombosis, and protein-losing enteropathy (CHAPLE) [MIM:226300]: An autosomal recessive disease characterized by abdominal pain and diarrhea, primary intestinal lymphangiectasia, edema due to hypoproteinemia, malabsorption, and less frequently, bowel inflammation, recurrent infections, and angiopathic thromboembolic disease. Patients' T lymphocytes show increased complement activation causing surface deposition of complement and the generation of soluble C5a. {ECO:0000269|PubMed:28657829, ECO:0000269|PubMed:28657861}. Note=The disease is caused by variants affecting the gene represented in this entry. CHAPLE is caused by biallelic mutations in the CD55 gene.
uniprot
proteins
function
FUNCTION: This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade (PubMed:7525274). Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage (PubMed:28657829). {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:28657829}.; FUNCTION: (Microbial infection) Acts as a receptor for Coxsackievirus A21, coxsackieviruses B1, B3 and B5. {ECO:0000269|PubMed:9151867}.; FUNCTION: (Microbial infection) Acts as a receptor for Human enterovirus 70 and D68 (Probable). {ECO:0000269|PubMed:8764022}.; FUNCTION: (Microbial infection) Acts as a receptor for Human echoviruses 6, 7, 11, 12, 20 and 21. {ECO:0000269|PubMed:7525274, ECO:0000305|PubMed:12409401}.
uniprot
proteins
mass_dalton
41400
uniprot
proteins
post_translational_modification
PTM: The Ser/Thr-rich domain is heavily O-glycosylated. {ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:26207632}.
uniprot
proteins
protein_family
Receptors of complement activation (RCA) family
uniprot
proteins
pubmed
11297558
uniprot
proteins
pubmed
12409401
uniprot
proteins
pubmed
12499389
uniprot
proteins
pubmed
12672958
uniprot
proteins
pubmed
12675719
uniprot
proteins
pubmed
1377029
uniprot
proteins
pubmed
14734808
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16503113
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
1711208
uniprot
proteins
pubmed
1712233
uniprot
proteins
pubmed
1720702
uniprot
proteins
pubmed
17804498
uniprot
proteins
pubmed
1824699
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2428813
uniprot
proteins
pubmed
2433596
uniprot
proteins
pubmed
2436222
uniprot
proteins
pubmed
26207632
uniprot
proteins
pubmed
28657829
uniprot
proteins
pubmed
28657861
uniprot
proteins
pubmed
7517044
uniprot
proteins
pubmed
7519480
uniprot
proteins
pubmed
7525274
uniprot
proteins
pubmed
7538177
uniprot
proteins
pubmed
8764022
uniprot
proteins
pubmed
9151867
uniprot
proteins
sequence_length
381
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Lipid-anchor, GPI-anchor.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000269|PubMed:16503113}.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted {ECO:0000269|PubMed:16503113}.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted {ECO:0000269|PubMed:16503113}.; SUBCELLULAR LOCATION: [Isoform 6]: Cell membrane {ECO:0000305|PubMed:16503113}; Lipid-anchor, GPI-anchor {ECO:0000305|PubMed:16503113}.; SUBCELLULAR LOCATION: [Isoform 7]: Cell membrane {ECO:0000305|PubMed:16503113}; Lipid-anchor, GPI-anchor {ECO:0000305|PubMed:16503113}.
uniprot
proteins