ERP27
entrez
121506
canonical
uniprot
Q96DN0
canonical
ensembl
ENSG00000139055
resolver
ensp
ENSP00000266397
resolver
ensp
ENSP00000440573
resolver
enst
ENST00000266397
resolver
enst
ENST00000540097
resolver
genesymbol
ERP27
resolver
genesymbol_syn
C12orf46
resolver
hgnc
HGNC:26495
resolver
uniprot
F5GYS6
resolver
uniprot_entry
ERP27_HUMAN
resolver
uniprot_entry
F5GYS6_HUMAN
resolver
amino_acid_sequence
MEAAPSRFMFLLFLLTCELAAEVAAEVEKSSDGPGAAQEPTWLTDVPAAMEFIAATEVAVIGFFQDLEIPAVPILHSMVQKFPGVSFGISTDSEVLTHYNITGNTICLFRLVDNEQLNLEDEDIESIDATKLSRFIEINSLHMVTEYNPVTVIGLFNSVIQIHLLLIMNKASPEYEENMHRYQKAAKLFQGKILFILVDSGMKENGKVISFFKLKESQLPALAIYQTLDDEWDTLPTAEVSVEHVQNFCDGFLSGKLLKENRESEGKTPKVEL
uniprot
proteins
function
FUNCTION: Specifically binds unfolded proteins and may recruit protein disulfide isomerase PDIA3 to unfolded substrates (PubMed:16940051, PubMed:23192347). Binds protein substrates via a hydrophobic pocket in the C-terminal domain (PubMed:16940051, PubMed:23192347). May play a role in the unfolded stress response (PubMed:23192347). {ECO:0000269|PubMed:16940051, ECO:0000269|PubMed:23192347}.
uniprot
proteins
mass_dalton
30480
uniprot
proteins
mutagenesis
MUTAGEN 168; /note="M->W: Decreases somatostatin-14 binding."; /evidence="ECO:0000269|PubMed:16940051"; MUTAGEN 196; /note="I->A,L,W: Decreases somatostatin-14 binding."; /evidence="ECO:0000269|PubMed:16940051"; MUTAGEN 196; /note="I->W: Conserved PDIA3 binding in vivo and in vitro."; /evidence="ECO:0000269|PubMed:16940051"; MUTAGEN 231; /note="E->K,A: Greatly reduces PDIA3 binding in vivo and in vitro."; /evidence="ECO:0000269|PubMed:16940051"; MUTAGEN 232; /note="W->A: Greatly reduces PDIA3 binding in vivo and in vitro."; /evidence="ECO:0000269|PubMed:16940051"; MUTAGEN 233; /note="D->G: Greatly reduces PDIA3 binding in vivo and in vitro."; /evidence="ECO:0000269|PubMed:16940051
uniprot
proteins
protein_family
Protein disulfide isomerase family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16940051
uniprot
proteins
pubmed
23192347
uniprot
proteins
sequence_length
273
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:16940051}.
uniprot
proteins