Slc32a1
entrez
83612
canonical
uniprot
O35458
canonical
ensembl
ENSRNOG00000015393
resolver
ensembl
ENSRNOG00055027414
resolver
ensembl
ENSRNOG00060026774
resolver
ensembl
ENSRNOG00065028288
resolver
ensp
ENSRNOP00000020720
resolver
ensp
ENSRNOP00055039036
resolver
ensp
ENSRNOP00060038540
resolver
ensp
ENSRNOP00065039956
resolver
enst
ENSRNOT00000020720
resolver
enst
ENSRNOT00055047459
resolver
enst
ENSRNOT00060046377
resolver
enst
ENSRNOT00065048724
resolver
genesymbol
Slc32a1
resolver
genesymbol_syn
Vgat
resolver
genesymbol_syn
Viaat
resolver
uniprot_entry
VIAAT_RAT
resolver
amino_acid_sequence
MATLLRSKLTNVATSVSNKSQAKVSGMFARMGFQAATDEEAVGFAHCDDLDFEHRQGLQMDILKSEGEPCGDEGAEPPVEGDIHYQRGGAPLPPSGSKDQAVGAGGEFGGHDKPKITAWEAGWNVTNAIQGMFVLGLPYAILHGGYLGLFLIIFAAVVCCYTGKILIACLYEENEDGEVVRVRDSYVAIANACCAPRFPTLGGRVVNVAQIIELVMTCILYVVVSGNLMYNSFPGLPVSQKSWSIIATAVLLPCAFLKNLKAVSKFSLLCTLAHFVINILVIAYCLSRARDWAWEKVKFYIDVKKFPISIGIIVFSYTSQIFLPSLEGNMQQPSEFHCMMNWTHIAACVLKGLFALVAYLTWADETKEVITDNLPGSIRAVVNIFLVAKALLSYPLPFFAAVEVLEKSLFQEGSRAFFPACYGGDGRLKSWGLTLRCALVVFTLLMAIYVPHFALLMGLTGSLTGAGLCFLLPSLFHLRLLWRKLLWHQVFFDVAIFVIGGICSVSGFVHSLEGLIEAYRTNAED
uniprot
proteins
function
FUNCTION: Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals (By similarity) (PubMed:9349821). The transport is equally dependent on the chemical and electrical components of the proton gradient (PubMed:9349821). May also transport beta-alanine (PubMed:23919636). Acidification of GABAergic synaptic vesicles is a prerequisite for 4-aminobutanoate uptake (By similarity). {ECO:0000250|UniProtKB:O35633, ECO:0000269|PubMed:23919636, ECO:0000269|PubMed:9349821}.
uniprot
proteins
mass_dalton
57407
uniprot
proteins
mutagenesis
MUTAGEN 213; /note="E->A: Loss of GABA and glycine transport activity. Loss of potential gradient-induced Cl(-) uptake. Loss of beta-alanine transport activity."; /evidence="ECO:0000269|PubMed:19843525, ECO:0000269|PubMed:23919636"; MUTAGEN 351; /note="K->A: Retains around 80% of the beta-alanine transport activity."; /evidence="ECO:0000269|PubMed:23919636
uniprot
proteins
protein_family
Amino acid/polyamine transporter 2 family
uniprot
proteins
pubmed
10036231
uniprot
proteins
pubmed
12031963
uniprot
proteins
pubmed
19052203
uniprot
proteins
pubmed
19843525
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23919636
uniprot
proteins
pubmed
9349821
uniprot
proteins
pubmed
9822734
uniprot
proteins
sequence_length
525
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:10036231, ECO:0000269|PubMed:9822734}; Multi-pass membrane protein {ECO:0000255}. Presynapse {ECO:0000269|PubMed:10036231}. Note=Presents in glycine-, GABA- or GABA- and glycine-containing boutons. {ECO:0000269|PubMed:10036231}.
uniprot
proteins
transmembrane_region
TRANSMEM 133..153; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 205..225; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 266..286; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 306..326; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 342..362; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 384..404; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 439..459; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 462..482; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 490..510; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins