Inha
entrez
24504
canonical
uniprot
P17490
canonical
ensembl
ENSRNOG00000020097
resolver
ensembl
ENSRNOG00055010599
resolver
ensembl
ENSRNOG00060008808
resolver
ensembl
ENSRNOG00065008516
resolver
ensp
ENSRNOP00000027227
resolver
ensp
ENSRNOP00055014443
resolver
ensp
ENSRNOP00060011396
resolver
ensp
ENSRNOP00065010015
resolver
enst
ENSRNOT00000027227
resolver
enst
ENSRNOT00055017939
resolver
enst
ENSRNOT00060014743
resolver
enst
ENSRNOT00065013511
resolver
genesymbol
Inha
resolver
uniprot_entry
INHA_RAT
resolver
amino_acid_sequence
MVIQPSLLLLLLLTLQDVDSCQGPELVRELVLAKVKALFLDALGPPAMDGEGGGPGIRRLPRRHALGGFMHRTSEPEEEDVSQAILFPATGATCEDQAAAGGLAQEPEEGLFTYVFRPSQHIRSHQVTSAQLWFHTGLDRKSTAASNSSRPLLDLLVLSSGGPMAVPVSLGQSPPRWAVLHLAASAFPLLTHPILVLLLRCPLCSCSGRPETTPFLVAHTRARAPSAGERARRSAPSMPWPWSPAALRLLQRPPEEPSAHAFCHRAALNISFQELGWDRWIVHPPSFIFHYCHGSCGMPTSDLPLPVPGAPPTPAQPLFLVPGAKPCCAALPGSMRSLRVRTTSDGGYSFKYEMVPNLITQHCACI
uniprot
proteins
function
FUNCTION: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. {ECO:0000250|UniProtKB:P05111}.; FUNCTION: Inhibin A is a dimer of alpha/INHA and beta-A/INHBA that functions as a feedback regulator in the hypothalamic-pituitary-gonadal (HPG) axis. Inhibits the secretion of FSH from the anterior pituitary gland by acting on pituitary gonadotrope cells. Antagonizes activin A by binding to the proteoglycan, betaglycan, and forming a stable complex with and, thereby, sequestering type II activin receptors while excluding type I receptor. {ECO:0000250|UniProtKB:P08476}.; FUNCTION: Inhibin B is a dimer of alpha and beta-B that plays a crucial role in the regulation of the reproductive system by inhibiting the secretion of follicle-stimulating hormone (FSH) from the anterior pituitary gland (PubMed:19589860). Thereby, maintains reproductive homeostasis in both males and females. Acts as a more potent suppressor of FSH release than inhibin A (By similarity). Functions as competitive receptor antagonist binding activin type II receptors with high affinity in the presence of the TGF-beta type III coreceptor/TGFBR3L (By similarity). {ECO:0000250|UniProtKB:P05111, ECO:0000269|PubMed:19589860}.
uniprot
proteins
mass_dalton
39497
uniprot
proteins
post_translational_modification
PTM: Proteolytic processing yields a number of bioactive forms, consisting either solely of the mature alpha chain, of the most N-terminal propeptide linked through a disulfide bond to the mature alpha chain, or of the entire proprotein.
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19589860
uniprot
proteins
pubmed
2484214
uniprot
proteins
pubmed
2628729
uniprot
proteins
pubmed
2829170
uniprot
proteins
pubmed
3153478
uniprot
proteins
sequence_length
366
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19589860}.
uniprot
proteins