TPM1
entrez
7168
canonical
uniprot
P09493
canonical
ensembl
ENSG00000140416
resolver
ensp
ENSP00000267996
resolver
ensp
ENSP00000288398
resolver
ensp
ENSP00000322577
resolver
ensp
ENSP00000334624
resolver
ensp
ENSP00000350667
resolver
ensp
ENSP00000351022
resolver
ensp
ENSP00000384315
resolver
ensp
ENSP00000385107
resolver
ensp
ENSP00000452658
resolver
ensp
ENSP00000452830
resolver
ensp
ENSP00000452879
resolver
ensp
ENSP00000453062
resolver
ensp
ENSP00000453724
resolver
ensp
ENSP00000453941
resolver
ensp
ENSP00000453955
resolver
ensp
ENSP00000498284
resolver
ensp
ENSP00000498540
resolver
ensp
ENSP00000519303
resolver
ensp
ENSP00000564017
resolver
ensp
ENSP00000610232
resolver
ensp
ENSP00000610235
resolver
ensp
ENSP00000653376
resolver
ensp
ENSP00000653378
resolver
ensp
ENSP00000653382
resolver
ensp
ENSP00000694560
resolver
ensp
ENSP00000694670
resolver
ensp
ENSP00000694678
resolver
ensp
ENSP00000747935
resolver
ensp
ENSP00000747955
resolver
ensp
ENSP00000775262
resolver
ensp
ENSP00000775263
resolver
ensp
ENSP00000775264
resolver
enst
ENST00000317516
resolver
enst
ENST00000357980
resolver
enst
ENST00000404484
resolver
enst
ENST00000558910
resolver
enst
ENST00000559281
resolver
enst
ENST00000560959
resolver
enst
ENST00000560970
resolver
enst
ENST00000651590
resolver
enst
ENST00000651622
resolver
genesymbol
HEL-S-265
resolver
genesymbol
TPM1
resolver
genesymbol_syn
C15orf13
resolver
genesymbol_syn
TMSA
resolver
genesymbol_syn
TPM1
resolver
hgnc
HGNC:12010
resolver
uniprot
A0A0K0K1I0
resolver
uniprot
A0A0S2Z4G6
resolver
uniprot
A0A494BZZ2
resolver
uniprot
A0A494C0I0
resolver
uniprot
A0ACM8QBN9
resolver
uniprot
B7Z596
resolver
uniprot
B7Z5T7
resolver
uniprot
B7Z722
resolver
uniprot
D9YZV2
resolver
uniprot
D9YZV3
resolver
uniprot
D9YZV8
resolver
uniprot
F5H7S3
resolver
uniprot
F6UI89
resolver
uniprot
H0YK48
resolver
uniprot
H0YKJ4
resolver
uniprot
H0YL52
resolver
uniprot
H0YMS6
resolver
uniprot
H7BYY1
resolver
uniprot
O15513
resolver
uniprot
P09494
resolver
uniprot
P10469
resolver
uniprot
Q6DV89
resolver
uniprot
Q6DV90
resolver
uniprot
Q6ZN40
resolver
uniprot
Q7Z6L8
resolver
uniprot
Q86W64
resolver
uniprot
Q96IK2
resolver
uniprot
Q9UCI1
resolver
uniprot
Q9UCI2
resolver
uniprot
Q9UCY9
resolver
uniprot
Q9Y427
resolver
uniprot_entry
A0A0K0K1I0_HUMAN
resolver
uniprot_entry
A0A0S2Z4G6_HUMAN
resolver
uniprot_entry
A0A494BZZ2_HUMAN
resolver
uniprot_entry
A0ACM8QBN9_HUMAN
resolver
uniprot_entry
B7Z596_HUMAN
resolver
uniprot_entry
B7Z722_HUMAN
resolver
uniprot_entry
F5H7S3_HUMAN
resolver
uniprot_entry
F6UI89_HUMAN
resolver
uniprot_entry
H0YK48_HUMAN
resolver
uniprot_entry
H0YKJ4_HUMAN
resolver
uniprot_entry
H0YMS6_HUMAN
resolver
uniprot_entry
H7BYY1_HUMAN
resolver
uniprot_entry
O15513_HUMAN
resolver
uniprot_entry
Q6ZN40_HUMAN
resolver
uniprot_entry
TPM1_HUMAN
resolver
uniprot_sec
A0A494C0I0
resolver
uniprot_sec
B7Z5T7
resolver
uniprot_sec
D9YZV2
resolver
uniprot_sec
D9YZV3
resolver
uniprot_sec
D9YZV8
resolver
uniprot_sec
H0YL52
resolver
uniprot_sec
P09494
resolver
uniprot_sec
P10469
resolver
uniprot_sec
Q6DV89
resolver
uniprot_sec
Q6DV90
resolver
uniprot_sec
Q7Z6L8
resolver
uniprot_sec
Q86W64
resolver
uniprot_sec
Q96IK2
resolver
uniprot_sec
Q9UCI1
resolver
uniprot_sec
Q9UCI2
resolver
uniprot_sec
Q9UCY9
resolver
uniprot_sec
Q9Y427
resolver
amino_acid_sequence
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKQLEDELVSLQKKLKGTEDELDKYSEALKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDRYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI
uniprot
proteins
disease_involvement
DISEASE: Cardiomyopathy, familial hypertrophic, 3 (CMH3) [MIM:115196]: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. {ECO:0000269|PubMed:12974739, ECO:0000269|PubMed:23170982, ECO:0000269|PubMed:7898523, ECO:0000269|PubMed:8205619, ECO:0000269|PubMed:8523464, ECO:0000269|PubMed:9822100}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Cardiomyopathy, dilated, 1Y (CMD1Y) [MIM:611878]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. {ECO:0000269|PubMed:11273725}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Left ventricular non-compaction 9 (LVNC9) [MIM:611878]: A form of left ventricular non-compaction, a cardiomyopathy due to myocardial morphogenesis arrest and characterized by a hypertrophic left ventricle, a severely thickened 2-layered myocardium, numerous prominent trabeculations, deep intertrabecular recesses, and poor systolic function. Clinical manifestations are variable. Some affected individuals experience no symptoms at all, others develop heart failure. In some cases, left ventricular non-compaction is associated with other congenital heart anomalies. LVNC9 is an autosomal dominant condition. {ECO:0000269|PubMed:21551322}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Binds to actin filaments in muscle and non-muscle cells (PubMed:23170982). Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction (PubMed:23170982). Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments.
uniprot
proteins
mass_dalton
32709
uniprot
proteins
mutagenesis
MUTAGEN 15; /note="K->N: Impairs interaction with LMOD2 and TMOD1."; /evidence="ECO:0000269|PubMed:26873245"; MUTAGEN 283; /note="S->A: Loss of phosphorylation and decreased formation of actin stress fibers."; /evidence="ECO:0000269|PubMed:17895359"; MUTAGEN 283; /note="S->E: Increased formation of actin stress fibers."; /evidence="ECO:0000269|PubMed:17895359
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-283 by DAPK1 in response to oxidative stress and this phosphorylation enhances stress fiber formation in endothelial cells. {ECO:0000269|PubMed:17895359}.
uniprot
proteins
protein_family
Tropomyosin family
uniprot
proteins
pubmed
11273725
uniprot
proteins
pubmed
11840567
uniprot
proteins
pubmed
12974739
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15249230
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
17895359
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21551322
uniprot
proteins
pubmed
23170982
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26873245
uniprot
proteins
pubmed
3138425
uniprot
proteins
pubmed
3336357
uniprot
proteins
pubmed
3336363
uniprot
proteins
pubmed
3548719
uniprot
proteins
pubmed
7898523
uniprot
proteins
pubmed
8205619
uniprot
proteins
pubmed
8450225
uniprot
proteins
pubmed
8523464
uniprot
proteins
pubmed
9822100
uniprot
proteins
sequence_length
284
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P04692}. Note=Associates with F-actin stress fibers. {ECO:0000250|UniProtKB:P04692}.
uniprot
proteins