Guca1b
entrez
107477
canonical
uniprot
Q8VBV8
canonical
ensembl
ENSMUSG00000023979
resolver
ensp
ENSMUSP00000024774
resolver
ensp
ENSMUSP00000126799
resolver
enst
ENSMUST00000024774
resolver
enst
ENSMUST00000145462
resolver
genesymbol
Guca1b
resolver
uniprot
E9PWU1
resolver
uniprot_entry
E9PWU1_MOUSE
resolver
uniprot_entry
GUC1B_MOUSE
resolver
amino_acid_sequence
MGQQLSWEEAEAAGEMDVAELQEWYKKFVVECPSGTLFMHEFKRFFKVTGNEEASQYVESMFRAFDKNGDNTIDFLEYVAALNLVLRGSLEHKLKWTFKIYDKDRNGCIDRLELLDIVEAIYKLKKACRAELDLEHQGQLLTPEEVVDRIFLLVDENGDGQLSLTEFIEGARRDKWVMKMLQMDINPGCWITQQRRRSAMF
uniprot
proteins
function
FUNCTION: Stimulates two retinal guanylyl cyclase (GCs) GUCY2E and GUCY2F when free calcium ions concentration is low, and inhibits GUCY2E and GUCY2F when free calcium ions concentration is elevated (By similarity). This Ca(2+)-sensitive regulation of GCs is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor response and recovery of response in bright light (PubMed:25673692). {ECO:0000250|UniProtKB:P51177, ECO:0000269|PubMed:25673692}.
uniprot
proteins
mass_dalton
23520
uniprot
proteins
post_translational_modification
PTM: The N-terminus is blocked. {ECO:0000250|UniProtKB:P51177}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15961391
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
25673692
uniprot
proteins
pubmed
29435986
uniprot
proteins
pubmed
9620085
uniprot
proteins
sequence_length
201
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P51177}; Lipid-anchor {ECO:0000250|UniProtKB:P51177}. Photoreceptor inner segment {ECO:0000269|PubMed:9620085}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:15961391, ECO:0000269|PubMed:9620085}. Note=Subcellular location is not affected by light or dark conditions. {ECO:0000269|PubMed:15961391}.
uniprot
proteins