Nsmce2
entrez
299957
canonical
uniprot
Q4V8A0
canonical
ensembl
ENSRNOG00000003964
resolver
ensembl
ENSRNOG00055025790
resolver
ensembl
ENSRNOG00060004386
resolver
ensembl
ENSRNOG00065004954
resolver
ensp
ENSRNOP00000005376
resolver
ensp
ENSRNOP00000085874
resolver
ensp
ENSRNOP00000097544
resolver
ensp
ENSRNOP00055036409
resolver
ensp
ENSRNOP00060005595
resolver
ensp
ENSRNOP00065004994
resolver
enst
ENSRNOT00000005376
resolver
enst
ENSRNOT00000099968
resolver
enst
ENSRNOT00000102133
resolver
enst
ENSRNOT00055044502
resolver
enst
ENSRNOT00060007380
resolver
enst
ENSRNOT00065007214
resolver
genesymbol
Nsmce2
resolver
genesymbol_syn
Mms21
resolver
uniprot
A0A8I6A069
resolver
uniprot
A0A8I6AS08
resolver
uniprot_entry
A0A8I6A069_RAT
resolver
uniprot_entry
A0A8I6AS08_RAT
resolver
uniprot_entry
NSE2_RAT
resolver
amino_acid_sequence
MPGRSSTNSGSTRYISFSGVESALSSLKTFQSCISSGMDTVSSVALDLVETQTEVSSEYSMDKAMVEFAKMDRELNHYVKAVQSTINHVKEERPEKVPDLKLLVEKKFLALQDKNSDADFKENEKFVQFKQQLRELKKQYGIHADRENDGIEGMDEDMIVTQSQTNFICPITQLEMKKPVKNKMCGHTYEEEAIVRMIESKHKRKKKACCPKIGCSHTDMRMSDLIPDEALRRAIESHNKKKKRHSE
uniprot
proteins
ec_number
2.3.2.-
uniprot
proteins
function
FUNCTION: E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TSNAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, RAD51AP1, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression. {ECO:0000250|UniProtKB:Q96MF7}.
uniprot
proteins
mass_dalton
28246
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein sumoylation. {ECO:0000250|UniProtKB:Q96MF7}.
uniprot
proteins
post_translational_modification
PTM: Sumoylated, possibly via autosumoylation. {ECO:0000250|UniProtKB:Q96MF7}.
uniprot
proteins
protein_family
NSE2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
247
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96MF7}. Chromosome, telomere {ECO:0000250|UniProtKB:Q96MF7}. Nucleus, PML body {ECO:0000250|UniProtKB:Q96MF7}. Note=Localizes to PML nuclear bodies in ALT cell lines. {ECO:0000250|UniProtKB:Q96MF7}.
uniprot
proteins