CTSB
entrez
1508
canonical
uniprot
P07858
canonical
ensembl
ENSG00000164733
resolver
ensembl
ENSG00000285132
resolver
ensp
ENSP00000342070
resolver
ensp
ENSP00000345672
resolver
ensp
ENSP00000431143
resolver
ensp
ENSP00000431518
resolver
ensp
ENSP00000432244
resolver
ensp
ENSP00000432408
resolver
ensp
ENSP00000433215
resolver
ensp
ENSP00000433379
resolver
ensp
ENSP00000433929
resolver
ensp
ENSP00000434217
resolver
ensp
ENSP00000434725
resolver
ensp
ENSP00000435074
resolver
ensp
ENSP00000435105
resolver
ensp
ENSP00000435260
resolver
ensp
ENSP00000435886
resolver
ensp
ENSP00000493857
resolver
ensp
ENSP00000494729
resolver
ensp
ENSP00000502963
resolver
ensp
ENSP00000503006
resolver
ensp
ENSP00000503052
resolver
ensp
ENSP00000503078
resolver
ensp
ENSP00000503174
resolver
ensp
ENSP00000503280
resolver
ensp
ENSP00000503300
resolver
ensp
ENSP00000503435
resolver
ensp
ENSP00000503487
resolver
ensp
ENSP00000503513
resolver
ensp
ENSP00000503578
resolver
ensp
ENSP00000503608
resolver
ensp
ENSP00000503652
resolver
ensp
ENSP00000503674
resolver
ensp
ENSP00000503858
resolver
ensp
ENSP00000503909
resolver
ensp
ENSP00000504161
resolver
ensp
ENSP00000504226
resolver
ensp
ENSP00000504336
resolver
ensp
ENSP00000504480
resolver
ensp
ENSP00000504638
resolver
ensp
ENSP00000504659
resolver
ensp
ENSP00000504797
resolver
ensp
ENSP00000504808
resolver
ensp
ENSP00000518417
resolver
ensp
ENSP00000518418
resolver
ensp
ENSP00000518419
resolver
ensp
ENSP00000518420
resolver
ensp
ENSP00000518421
resolver
ensp
ENSP00000518426
resolver
ensp
ENSP00000518427
resolver
ensp
ENSP00000518428
resolver
ensp
ENSP00000518429
resolver
ensp
ENSP00000518430
resolver
ensp
ENSP00000518431
resolver
ensp
ENSP00000518432
resolver
ensp
ENSP00000518433
resolver
ensp
ENSP00000518434
resolver
ensp
ENSP00000518435
resolver
ensp
ENSP00000518436
resolver
ensp
ENSP00000518437
resolver
ensp
ENSP00000518438
resolver
ensp
ENSP00000518440
resolver
ensp
ENSP00000518441
resolver
ensp
ENSP00000518442
resolver
ensp
ENSP00000518443
resolver
ensp
ENSP00000518444
resolver
ensp
ENSP00000518445
resolver
ensp
ENSP00000518448
resolver
ensp
ENSP00000518449
resolver
ensp
ENSP00000518450
resolver
ensp
ENSP00000518452
resolver
ensp
ENSP00000518455
resolver
ensp
ENSP00000518456
resolver
ensp
ENSP00000518457
resolver
ensp
ENSP00000518460
resolver
ensp
ENSP00000518464
resolver
ensp
ENSP00000518466
resolver
ensp
ENSP00000518468
resolver
ensp
ENSP00000518469
resolver
ensp
ENSP00000570712
resolver
ensp
ENSP00000570713
resolver
ensp
ENSP00000570714
resolver
ensp
ENSP00000570715
resolver
ensp
ENSP00000570716
resolver
ensp
ENSP00000570717
resolver
ensp
ENSP00000570718
resolver
ensp
ENSP00000570719
resolver
ensp
ENSP00000570720
resolver
ensp
ENSP00000570721
resolver
ensp
ENSP00000570722
resolver
ensp
ENSP00000570723
resolver
ensp
ENSP00000570724
resolver
ensp
ENSP00000570726
resolver
ensp
ENSP00000570727
resolver
ensp
ENSP00000570728
resolver
ensp
ENSP00000570729
resolver
ensp
ENSP00000570730
resolver
ensp
ENSP00000570731
resolver
ensp
ENSP00000570732
resolver
ensp
ENSP00000570733
resolver
ensp
ENSP00000570734
resolver
ensp
ENSP00000570735
resolver
ensp
ENSP00000570737
resolver
ensp
ENSP00000570738
resolver
ensp
ENSP00000570739
resolver
ensp
ENSP00000570740
resolver
ensp
ENSP00000570743
resolver
ensp
ENSP00000570744
resolver
ensp
ENSP00000570745
resolver
ensp
ENSP00000570746
resolver
ensp
ENSP00000570747
resolver
ensp
ENSP00000570749
resolver
ensp
ENSP00000570750
resolver
ensp
ENSP00000570751
resolver
ensp
ENSP00000570752
resolver
ensp
ENSP00000570753
resolver
ensp
ENSP00000570754
resolver
ensp
ENSP00000609233
resolver
ensp
ENSP00000617659
resolver
ensp
ENSP00000617661
resolver
ensp
ENSP00000617662
resolver
ensp
ENSP00000617663
resolver
ensp
ENSP00000617665
resolver
ensp
ENSP00000617667
resolver
ensp
ENSP00000617669
resolver
ensp
ENSP00000617672
resolver
ensp
ENSP00000617673
resolver
ensp
ENSP00000617674
resolver
ensp
ENSP00000617675
resolver
ensp
ENSP00000617676
resolver
ensp
ENSP00000617677
resolver
ensp
ENSP00000617678
resolver
ensp
ENSP00000617679
resolver
ensp
ENSP00000617680
resolver
ensp
ENSP00000617682
resolver
ensp
ENSP00000617684
resolver
ensp
ENSP00000617685
resolver
ensp
ENSP00000617687
resolver
ensp
ENSP00000617688
resolver
ensp
ENSP00000617689
resolver
ensp
ENSP00000617690
resolver
ensp
ENSP00000617693
resolver
ensp
ENSP00000617694
resolver
ensp
ENSP00000617695
resolver
ensp
ENSP00000617696
resolver
ensp
ENSP00000617697
resolver
ensp
ENSP00000617698
resolver
ensp
ENSP00000617699
resolver
ensp
ENSP00000617700
resolver
ensp
ENSP00000617703
resolver
ensp
ENSP00000617704
resolver
ensp
ENSP00000617705
resolver
ensp
ENSP00000617706
resolver
ensp
ENSP00000617707
resolver
ensp
ENSP00000617708
resolver
ensp
ENSP00000617709
resolver
ensp
ENSP00000617710
resolver
ensp
ENSP00000617714
resolver
ensp
ENSP00000617716
resolver
ensp
ENSP00000617720
resolver
ensp
ENSP00000617721
resolver
ensp
ENSP00000617724
resolver
ensp
ENSP00000617725
resolver
ensp
ENSP00000617726
resolver
ensp
ENSP00000617727
resolver
ensp
ENSP00000617728
resolver
ensp
ENSP00000617729
resolver
ensp
ENSP00000617731
resolver
ensp
ENSP00000617733
resolver
ensp
ENSP00000617734
resolver
ensp
ENSP00000617735
resolver
ensp
ENSP00000617736
resolver
ensp
ENSP00000617737
resolver
ensp
ENSP00000617738
resolver
ensp
ENSP00000617739
resolver
ensp
ENSP00000617740
resolver
ensp
ENSP00000617741
resolver
ensp
ENSP00000617743
resolver
ensp
ENSP00000617744
resolver
ensp
ENSP00000617745
resolver
ensp
ENSP00000617746
resolver
ensp
ENSP00000617747
resolver
ensp
ENSP00000617748
resolver
ensp
ENSP00000617749
resolver
ensp
ENSP00000617750
resolver
ensp
ENSP00000617751
resolver
enst
ENST00000345125
resolver
enst
ENST00000353047
resolver
enst
ENST00000526645
resolver
enst
ENST00000527215
resolver
enst
ENST00000527243
resolver
enst
ENST00000528965
resolver
enst
ENST00000530296
resolver
enst
ENST00000530640
resolver
enst
ENST00000531089
resolver
enst
ENST00000531502
resolver
enst
ENST00000532392
resolver
enst
ENST00000532656
resolver
enst
ENST00000533455
resolver
enst
ENST00000534382
resolver
enst
ENST00000534510
resolver
enst
ENST00000646105
resolver
enst
ENST00000646239
resolver
enst
ENST00000676691
resolver
enst
ENST00000676755
resolver
enst
ENST00000676825
resolver
enst
ENST00000676843
resolver
enst
ENST00000676952
resolver
enst
ENST00000677082
resolver
enst
ENST00000677366
resolver
enst
ENST00000677415
resolver
enst
ENST00000677418
resolver
enst
ENST00000677544
resolver
enst
ENST00000677650
resolver
enst
ENST00000677671
resolver
enst
ENST00000677819
resolver
enst
ENST00000677873
resolver
enst
ENST00000678092
resolver
enst
ENST00000678145
resolver
enst
ENST00000678242
resolver
enst
ENST00000678357
resolver
enst
ENST00000678615
resolver
enst
ENST00000678929
resolver
enst
ENST00000679051
resolver
enst
ENST00000679128
resolver
enst
ENST00000679140
resolver
enst
ENST00000710700
resolver
enst
ENST00000710702
resolver
enst
ENST00000710703
resolver
enst
ENST00000710704
resolver
enst
ENST00000710705
resolver
enst
ENST00000710713
resolver
enst
ENST00000710714
resolver
enst
ENST00000710715
resolver
enst
ENST00000710716
resolver
enst
ENST00000710717
resolver
enst
ENST00000710718
resolver
enst
ENST00000710719
resolver
enst
ENST00000710720
resolver
enst
ENST00000710721
resolver
enst
ENST00000710722
resolver
enst
ENST00000710723
resolver
enst
ENST00000710724
resolver
enst
ENST00000710725
resolver
enst
ENST00000710727
resolver
enst
ENST00000710728
resolver
enst
ENST00000710729
resolver
enst
ENST00000710730
resolver
enst
ENST00000710731
resolver
enst
ENST00000710732
resolver
enst
ENST00000710743
resolver
enst
ENST00000710744
resolver
enst
ENST00000710745
resolver
enst
ENST00000710747
resolver
enst
ENST00000710750
resolver
enst
ENST00000710751
resolver
enst
ENST00000710752
resolver
enst
ENST00000710755
resolver
enst
ENST00000710759
resolver
enst
ENST00000710761
resolver
enst
ENST00000710763
resolver
enst
ENST00000710764
resolver
enst
ENST00000900653
resolver
enst
ENST00000900654
resolver
enst
ENST00000900655
resolver
enst
ENST00000900656
resolver
enst
ENST00000900657
resolver
enst
ENST00000900658
resolver
enst
ENST00000900659
resolver
enst
ENST00000900660
resolver
enst
ENST00000900661
resolver
enst
ENST00000900662
resolver
enst
ENST00000900663
resolver
enst
ENST00000900664
resolver
enst
ENST00000900665
resolver
enst
ENST00000900667
resolver
enst
ENST00000900668
resolver
enst
ENST00000900669
resolver
enst
ENST00000900670
resolver
enst
ENST00000900671
resolver
enst
ENST00000900672
resolver
enst
ENST00000900673
resolver
enst
ENST00000900674
resolver
enst
ENST00000900675
resolver
enst
ENST00000900676
resolver
enst
ENST00000900678
resolver
enst
ENST00000900679
resolver
enst
ENST00000900680
resolver
enst
ENST00000900681
resolver
enst
ENST00000900684
resolver
enst
ENST00000900685
resolver
enst
ENST00000900686
resolver
enst
ENST00000900687
resolver
enst
ENST00000900688
resolver
enst
ENST00000900690
resolver
enst
ENST00000900691
resolver
enst
ENST00000900692
resolver
enst
ENST00000900693
resolver
enst
ENST00000900694
resolver
enst
ENST00000900695
resolver
enst
ENST00000939174
resolver
enst
ENST00000947600
resolver
enst
ENST00000947602
resolver
enst
ENST00000947603
resolver
enst
ENST00000947604
resolver
enst
ENST00000947606
resolver
enst
ENST00000947608
resolver
enst
ENST00000947610
resolver
enst
ENST00000947613
resolver
enst
ENST00000947614
resolver
enst
ENST00000947615
resolver
enst
ENST00000947616
resolver
enst
ENST00000947617
resolver
enst
ENST00000947618
resolver
enst
ENST00000947619
resolver
enst
ENST00000947620
resolver
enst
ENST00000947621
resolver
enst
ENST00000947623
resolver
enst
ENST00000947625
resolver
enst
ENST00000947626
resolver
enst
ENST00000947628
resolver
enst
ENST00000947629
resolver
enst
ENST00000947630
resolver
enst
ENST00000947631
resolver
enst
ENST00000947634
resolver
enst
ENST00000947635
resolver
enst
ENST00000947636
resolver
enst
ENST00000947637
resolver
enst
ENST00000947638
resolver
enst
ENST00000947639
resolver
enst
ENST00000947640
resolver
enst
ENST00000947641
resolver
enst
ENST00000947644
resolver
enst
ENST00000947645
resolver
enst
ENST00000947646
resolver
enst
ENST00000947647
resolver
enst
ENST00000947648
resolver
enst
ENST00000947649
resolver
enst
ENST00000947650
resolver
enst
ENST00000947651
resolver
enst
ENST00000947655
resolver
enst
ENST00000947657
resolver
enst
ENST00000947661
resolver
enst
ENST00000947662
resolver
enst
ENST00000947665
resolver
enst
ENST00000947666
resolver
enst
ENST00000947667
resolver
enst
ENST00000947668
resolver
enst
ENST00000947669
resolver
enst
ENST00000947670
resolver
enst
ENST00000947672
resolver
enst
ENST00000947674
resolver
enst
ENST00000947675
resolver
enst
ENST00000947676
resolver
enst
ENST00000947677
resolver
enst
ENST00000947678
resolver
enst
ENST00000947679
resolver
enst
ENST00000947680
resolver
enst
ENST00000947681
resolver
enst
ENST00000947682
resolver
enst
ENST00000947684
resolver
enst
ENST00000947685
resolver
enst
ENST00000947686
resolver
enst
ENST00000947687
resolver
enst
ENST00000947688
resolver
enst
ENST00000947689
resolver
enst
ENST00000947690
resolver
enst
ENST00000947691
resolver
enst
ENST00000947692
resolver
genesymbol
CTSB
resolver
genesymbol_syn
CPSB
resolver
hgnc
HGNC:2527
resolver
uniprot
A0A024R374
resolver
uniprot
B3KQR5
resolver
uniprot
B3KRR5
resolver
uniprot
Q503A6
resolver
uniprot
Q96D87
resolver
uniprot_entry
A0A024R374_HUMAN
resolver
uniprot_entry
CATB_HUMAN
resolver
uniprot_sec
B3KQR5
resolver
uniprot_sec
B3KRR5
resolver
uniprot_sec
Q503A6
resolver
uniprot_sec
Q96D87
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by leupeptin. {ECO:0000269|PubMed:12220505}.
uniprot
proteins
amino_acid_sequence
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
uniprot
proteins
disease_involvement
DISEASE: Keratolytic winter erythema (KWE) [MIM:148370]: An autosomal dominant genodermatosis characterized by recurrent episodes of palmoplantar erythema and epidermal peeling presenting seasonal variation. KWE manifests during childhood. Skin lesions may spread to the dorsum of hands and feet and to the interdigital spaces. Lower legs, knees and thighs may also be involved. A less common finding is a slowly migratory, annular erythema that is seen mostly on the extremities. Between flares, the skin can appear unremarkable. Itching can occur, and hyperhidrosis, associated with a pungent odor, is invariably present. Formation of vesicles is rare, whereas keratolysis that causes the formation of dry blisters is regularly seen. Cold weather, moisture, febrile diseases, and physical and mental stress can trigger exacerbations. In severely affected individuals, skin manifestations persist unremittingly. Penetrance of the disease is high, but expressivity is variable, even within the same family. {ECO:0000269|PubMed:28457472}. Note=The gene represented in this entry is involved in disease pathogenesis. Tandem duplications in a non-coding genomic region containing an active enhancer element for CTSB result in CTSB abnormal expression with pathological consequences. {ECO:0000269|PubMed:28457472}.
uniprot
proteins
ec_number
3.4.22.1
uniprot
proteins
function
FUNCTION: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:12220505). Cleaves matrix extracellular phosphoglycoprotein MEPE (PubMed:12220505). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (PubMed:3972105). {ECO:0000250|UniProtKB:P10605, ECO:0000269|PubMed:12220505, ECO:0000269|PubMed:3972105}.
uniprot
proteins
mass_dalton
37822
uniprot
proteins
protein_family
Peptidase C1 family
uniprot
proteins
pubmed
12220505
uniprot
proteins
pubmed
12643545
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
1637335
uniprot
proteins
pubmed
16733801
uniprot
proteins
pubmed
17081065
uniprot
proteins
pubmed
1868826
uniprot
proteins
pubmed
18718938
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28457472
uniprot
proteins
pubmed
3010323
uniprot
proteins
pubmed
3463996
uniprot
proteins
pubmed
37990007
uniprot
proteins
pubmed
3972105
uniprot
proteins
pubmed
8112600
uniprot
proteins
pubmed
8617355
uniprot
proteins
pubmed
9299326
uniprot
proteins
sequence_length
339
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:16733801}. Melanosome {ECO:0000269|PubMed:17081065}. Secreted, extracellular space {ECO:0000250|UniProtKB:A1E295}. Apical cell membrane {ECO:0000250|UniProtKB:P10605}; Peripheral membrane protein {ECO:0000250|UniProtKB:P10605}; Extracellular side {ECO:0000250|UniProtKB:P10605}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells (By similarity). {ECO:0000250|UniProtKB:P10605, ECO:0000269|PubMed:17081065}.
uniprot
proteins