SEC62
entrez
7095
canonical
uniprot
Q99442
canonical
ensembl
ENSG00000008952
resolver
ensp
ENSP00000337688
resolver
ensp
ENSP00000420331
resolver
enst
ENST00000337002
resolver
enst
ENST00000480708
resolver
genesymbol
SEC62
resolver
genesymbol_syn
TLOC1
resolver
hgnc
HGNC:11846
resolver
uniprot
D3DNQ0
resolver
uniprot
O00682
resolver
uniprot
O00729
resolver
uniprot_entry
SEC62_HUMAN
resolver
uniprot_sec
D3DNQ0
resolver
uniprot_sec
O00682
resolver
uniprot_sec
O00729
resolver
amino_acid_sequence
MAERRRHKKRIQEVGEPSKEEKAVAKYLRFNCPTKSTNMMGHRVDYFIASKAVDCLLDSKWAKAKKGEEALFTTRESVVDYCNRLLKKQFFHRALKVMKMKYDKDIKKEKDKGKAESGKEEDKKSKKENIKDEKTKKEKEKKKDGEKEESKKEETPGTPKKKETKKKFKLEPHDDQVFLDGNEVYVWIYDPVHFKTFVMGLILVIAVIAATLFPLWPAEMRVGVYYLSVGAGCFVASILLLAVARCILFLIIWLITGGRHHFWFLPNLTADVGFIDSFRPLYTHEYKGPKADLKKDEKSETKKQQKSDSEEKSDSEKKEDEEGKVGPGNHGTEGSGGERHSDTDSDRREDDRSQHSSGNGNDFEMITKEELEQQTDGDCEEDEEEENDGETPKSSHEKS
uniprot
proteins
function
FUNCTION: Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides. Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen. {ECO:0000269|PubMed:22375059, ECO:0000269|PubMed:29719251}.
uniprot
proteins
mass_dalton
45862
uniprot
proteins
protein_family
SEC62 family
uniprot
proteins
pubmed
10683767
uniprot
proteins
pubmed
10799540
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22375059
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29719251
uniprot
proteins
pubmed
32620754
uniprot
proteins
pubmed
9020021
uniprot
proteins
sequence_length
399
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 197..217; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 235..255; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins