Desi1
entrez
28075
canonical
uniprot
Q9CQT7
canonical
ensembl
ENSMUSG00000022472
resolver
ensp
ENSMUSP00000121504
resolver
ensp
ENSMUSP00000261988
resolver
enst
ENSMUST00000152227
resolver
genesymbol
Desi1
resolver
genesymbol_syn
D15Wsu75e
resolver
genesymbol_syn
Fam152b
resolver
genesymbol_syn
Pppde2
resolver
uniprot
Q3V2M9
resolver
uniprot_entry
DESI1_MOUSE
resolver
uniprot_sec
Q3V2M9
resolver
amino_acid_sequence
MEPPNLYPVKLYVYDLSKGLARRLSPIMLGKQLEGIWHTSIVVHKDEFFFGSSGISSCTPGGTLLGPPDSVVDVGNTEVTEEIFLEYLSSLGESLFRGEAYNLFEHNCNTFSNEVAQFLTGRKIPSYITDLPSEVLSTPFGQALRPFLDSIQIQPPGGNSVGRPNGQS
uniprot
proteins
ec_number
3.1.2.22
uniprot
proteins
ec_number
3.4.-.-
uniprot
proteins
function
FUNCTION: Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins (PubMed:22370726, PubMed:22498933). Has isopeptidase but not SUMO-processing activity (PubMed:22370726, PubMed:22498933). Desumoylates ZBTB46 (PubMed:22370726). Collaborates with UBQLN4 in the export of ubiquitinated proteins from the nucleus to the cytoplasm (By similarity). Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity towards synthetic substrates 4-methylumbelliferyl-6-S-palmitoyl-beta-D-glucopyranoside and S-depalmitoylation probe 5 (DPP-5) (By similarity). {ECO:0000250|UniProtKB:Q6ICB0, ECO:0000269|PubMed:22370726, ECO:0000269|PubMed:22498933}.
uniprot
proteins
mass_dalton
18385
uniprot
proteins
protein_family
DeSI family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22370726
uniprot
proteins
pubmed
22498933
uniprot
proteins
sequence_length
168
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22370726}. Nucleus {ECO:0000269|PubMed:22370726}. Note=Shuttles between the nucleus and the cytoplasm; exported from the nucleus in a XPO1/CRM1-dependent manner via its nuclear export signal motifs. {ECO:0000250|UniProtKB:Q6ICB0}.
uniprot
proteins