Alg13
entrez
67574
canonical
uniprot
Q9D8C3
canonical
ensembl
ENSMUSG00000041718
resolver
ensp
ENSMUSP00000068403
resolver
genesymbol
Alg13
resolver
uniprot
A3KGC8
resolver
uniprot
A3KGD0
resolver
uniprot
A3KGD1
resolver
uniprot
Q8BUA4
resolver
uniprot
Q9D5Z6
resolver
uniprot_entry
ALG13_MOUSE
resolver
uniprot_sec
A3KGC8
resolver
uniprot_sec
A3KGD0
resolver
uniprot_sec
A3KGD1
resolver
uniprot_sec
Q8BUA4
resolver
uniprot_sec
Q9D5Z6
resolver
amino_acid_sequence
MKRAFVTVGTTSFDELVARVVANDCVQILESLGYNHLVLQVGRGTVVPKPFRTESFTLDVYRYKDSLKEDLQQADLVISHAGAGSCLESLEKGKPLVVVVNEKLMNNHQFELAKQLHKEGHLFYCTCRVLSCPAPVSLLLVLLGSAKILQQLPSATLSCFGYLPTQAPVLVATAYSYLHSVFSSFPPLSTFLIIPCTMQKGWKKYCGQKSLNEASMDEYLGSLGLFRKVVAKDASCLFRAISEQLFHSQIHHLQIRRACVSYMKENQQAFESYVEGSFEKYLERLGDPKESAGQLELKALSLIYNRDFIIYRYPGKPPTQVTDNGFEDKIILCYSNNGHYDSVYSKEFQSTAGICQAILYELLYKDVFVVDEETLKTAVDLFRSGSRRNKHHALTASVEGSSDQKSSTEDRTEEAAACSSAASTPEGNKQGTERQKVPESPSKMLFPYKVLKALDPEIYRNVEFDAWLDSRKELQKSECVEYGGRYYFLGDKCQVCMESGGKYYNAHIQEIDNDKSSVVVFIEEFAERHSIPLAHVRPVNQVALLPSWNAIPIRNGRGYPTITGGYFPEIVMTDMNMKQRKKMFKKFRGKEIYMTMAYSRGDPLVPSRIQHSMHYGHDPLLYYSQTAGHILSSQHFYPQHSSQRQGRGYGMPRDSSHLISKQNLPNPKVGFCSGSGRKCCQSYDNVSYRSRSFRRSHRQMHCMNKGCQYGFAPENGVEETVTFYALEEGNETAYSTLPNNGGPTTMVPATSGYCVARQGYNSCKPPLNSGDSNDHCDNGGYHGDYLYSSEQGYETSSVYTTTVSTANLSLQDSGPSSVPQDTVTSYNYPQKVLENSAAIAVSWASHVPVPVIPNCAGDNEALRTSDISSQNAIQPGFVPPPAQGSPAYLEPSAAGAAGAAAAAAAAAAPVATPVAAPLPLPPPLPPPPPATLEAGDASGFPLPPPPPPPPPPPPPYSYDPSGSDLPQDTKVLQYYFNLGLQCYHHNYWHPMVYMPHVQQQLQPQPQPQPQPQPQPQPQPQPQPQQPQQQQPPPQQQQQQQEQVHGESYPDCTEQPLVDQSAPQVYSDVVREDGTQADVSTNDTFPIADAVPLPHGAVYYPVMTDPYGSPLLGFDSYVPVASDYSSIAMWHPVNAACGASAQIHGAMNPGPIGYMLLPNSPHYTPQN
uniprot
proteins
ec_number
2.4.1.141
uniprot
proteins
function
FUNCTION: Catalytic subunit of the UDP-N-acetylglucosamine transferase complex that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. On the cytoplasmic face of the endoplasmic reticulum, the dimeric ALG13/ALG14 complex catalyzes the second step of dolichol pyrophosphate biosynthesis, transferring a beta1,4-linked N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to GlcNAc-pyrophosphatedolichol (Gn-PDol) to produce N,N'-diacetylchitobiosyl diphosphodolichol. N,N'-diacetylchitobiosyl diphosphodolichol is a substrate for ALG1, the following enzyme in the biosynthetic pathway. {ECO:0000250|UniProtKB:Q9NP73}.; FUNCTION: [Isoform 2]: Catalytic subunit of the UDP-N-acetylglucosamine transferase complex that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. On the cytoplasmic face of the endoplasmic reticulum, the dimeric ALG13/ALG14 complex catalyzes the second step of dolichol pyrophosphate biosynthesis, transferring a beta1,4-linked N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to GlcNAc-pyrophosphatedolichol (Gn-PDol) to produce N,N'-diacetylchitobiosyl diphosphodolichol. N,N'-diacetylchitobiosyl diphosphodolichol is a substrate for ALG1, the following enzyme in the biosynthetic pathway. {ECO:0000250|UniProtKB:Q9NP73}.; FUNCTION: [Isoform 1]: No glycosyltransferase or deubiquitinase activity is detected for this potential multifunctional enzyme. {ECO:0000250|UniProtKB:Q9NP73}.
uniprot
proteins
mass_dalton
128664
uniprot
proteins
pathway_participation
PATHWAY: [Isoform 2]: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:Q9NP73}.
uniprot
proteins
protein_family
Glycosyltransferase 28 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30872163
uniprot
proteins
sequence_length
1166
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9NP73}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9NP73}. Note=Recruited to the cytosolic face of the endoplasmic reticulum membrane through its interaction with ALG14. {ECO:0000250|UniProtKB:Q9NP73}.
uniprot
proteins