Eif4ebp3
entrez
108112
canonical
uniprot
Q80VV3
canonical
ensembl
ENSMUSG00000090264
resolver
ensp
ENSMUSP00000039298
resolver
enst
ENSMUST00000036765
resolver
genesymbol
Eif4ebp3
resolver
uniprot
Q2TA53
resolver
uniprot_entry
4EBP3_MOUSE
resolver
uniprot_sec
Q2TA53
resolver
amino_acid_sequence
MSSSTSCPIPGCRDQLPDGYSTTPGGTLYATTPGGTRIIYDRKFLLECKNSPIARTPPCCLPQIPGVTTLPAVPPSKLELLKEQKQTEVEITDDEQFEMDM
uniprot
proteins
function
FUNCTION: Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: the hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repression of translation. In contrast, the hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Inhibits EIF4E-mediated mRNA nuclear export (By similarity). {ECO:0000250|UniProtKB:O60516, ECO:0000250|UniProtKB:Q13541}.
uniprot
proteins
mass_dalton
11019
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250|UniProtKB:O60516}.
uniprot
proteins
protein_family
EIF4E-binding protein family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
101
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O60516}. Nucleus {ECO:0000250|UniProtKB:O60516}.
uniprot
proteins