Mcm9
entrez
71567
canonical
uniprot
Q2KHI9
canonical
ensembl
ENSMUSG00000058298
resolver
ensp
ENSMUSP00000151639
resolver
ensp
ENSMUSP00000151893
resolver
ensp
ENSMUSP00000157761
resolver
genesymbol
Mcm9
resolver
genesymbol_syn
Mcmdc1
resolver
uniprot
Q3V370
resolver
uniprot
Q6P6J6
resolver
uniprot
Q9D344
resolver
uniprot_entry
MCM9_MOUSE
resolver
uniprot_sec
Q3V370
resolver
uniprot_sec
Q6P6J6
resolver
uniprot_sec
Q9D344
resolver
amino_acid_sequence
MNSEQVTLVGQVFESYVSEYHKNDILLILKERDEDAHYPVVVNAMSLFETNMEIGDYFTVFPNEVLTVFDSALRRSALAILQSLPETEGLSMKQNLHARISGLPVCPELVREHIPKTKDVGHFLSVTGTVIRTSLVKVLEFERDYMCNKCKHVFMVEADFEQYYTFSRPSSCPSLASCDSSKFSCLSDLSSSPARCRDYQEIKIQEQVQRLSVGSIPRSMKVILEDDLVDSCKSGDDLTIYGVVMQRWKPFQRDVRCEVEIVLKANYVQVNNEQSSGMVMDEDTRKEFEDFWEHYKSDPFAGRNEILASLCPQVFGMYLVKLAVAMVLAGGIQRTDAAGTRVRGESHLLLVGDPGTGKSQFLKYAAKITPRSVLTTGIGSTSAGLTVTAVKDSGEWNLEAGALVLADAGLCCIDEFNSLKEHDRTSIHEAMEQQTISVAKAGLVCKLNTRTTILAATNPKGQYDPKESVSVNIALGSPLLSRFDLVLVLLDTRNEDWDRIISSFILENKGYPSKSENLWSMEKMKTYFCLIRNLHPTLSEVSNQVLLRYYQMQRQSDSRNAARTTIRLLESLIRLAEAHARLMFRSAVTLEDAVTAVSVMESSMQGGALLGGVNALHTSFPENPRAQYQRQCELILEKLELQGLLQEELRRLERLQNESVHQCQSHSLEEEVAPGSCRNDPRDKPRLRTSTQQEQSCSWSSTERSGADSPPGPGLNRPTSCNNSAENRDGRGDGLDWLDPTSSPEIAPESTIVSPNVKTTEKNVNLKISNNKSQGKEKHGPQQRSKLLEAGHLPSSGAMNAPLRSHGVKRTKASQAVVVSEAGRGDEEDSVPRRLPKLLKEGSQNVCRSTTRVRPLPPTVPLSLSIPSPGSGKRSGTPKRKRRKSAQVEEPEPEGMETPTVKLAKFTFKQKTKLTHSPEGQGPIPPSASEIAVDSSKIPQQRTRREAAVPVVAPGKSTSTSGDRCSDQLHGKTKELSRQPPDSNPPREEREQGPKRRVIQPKPELGNQAGHSHLACEKDRKEGVSCGNKSSKVHAGTIARLASFSFTSPSESKSESLPPERKDSRDSRDSRDSRDRCHSPPATTAPVLGQQRQTFQLQQPTERANLSTLSLFTLSELDDEALDFDWEEEMRKKP
uniprot
proteins
ec_number
5.6.2.4
uniprot
proteins
function
FUNCTION: Component of the MCM8-MCM9 complex, which is involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:22771120, PubMed:23401855). The MCM8-MCM9 complex is a 3'-5' DNA helicase and single-stranded (ss)DNA-stimulated ATPase which binds ssDNA in the presence of nucleoside triphosphates (By similarity). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex at double-stranded DNA breaks to generate ssDNA by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (By similarity). Indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs, probably by regulating the localization of the MNR complex (PubMed:22771120, PubMed:23401855). Acts as a helicase in DNA mismatch repair (MMR) following DNA replication errors to unwind the mismatch containing DNA strand (PubMed:22771120, PubMed:26300262). In addition, recruits MLH1, a component of the MMR complex, to chromatin (By similarity). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:21987787). Probably by regulating HR, plays a key role during gametogenesis (PubMed:21987787, PubMed:22771120). {ECO:0000250|UniProtKB:Q9NXL9, ECO:0000269|PubMed:21987787, ECO:0000269|PubMed:22771120, ECO:0000269|PubMed:23401855, ECO:0000269|PubMed:26300262}.
uniprot
proteins
mass_dalton
125814
uniprot
proteins
protein_family
MCM family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15850810
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16226853
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21987787
uniprot
proteins
pubmed
22771120
uniprot
proteins
pubmed
23401855
uniprot
proteins
pubmed
26300262
uniprot
proteins
sequence_length
1134
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23401855}. Chromosome {ECO:0000269|PubMed:23401855}. Note=Colocalizes to nuclear foci with RPA1 following DNA damage (PubMed:23401855). Localizes to double-stranded DNA breaks (By similarity). Recruited to chromatin by MSH2 (By similarity). {ECO:0000250|UniProtKB:Q9NXL9, ECO:0000269|PubMed:23401855}.
uniprot
proteins