Aldoa
entrez
24189
canonical
uniprot
P05065
canonical
ensembl
ENSRNOG00000052802
resolver
ensembl
ENSRNOG00065016801
resolver
ensp
ENSRNOP00000069540
resolver
ensp
ENSRNOP00000093578
resolver
ensp
ENSRNOP00065022178
resolver
enst
ENSRNOT00000088473
resolver
enst
ENSRNOT00065028062
resolver
genesymbol
Aldoa
resolver
uniprot
Q63038
resolver
uniprot_entry
ALDOA_RAT
resolver
uniprot_sec
Q63038
resolver
amino_acid_sequence
MPHPYPALTPEQKKELADIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSSLAIMENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHVYLEGTLLKPNMVTPGHACTQKFSNEEIAMATVTALRRTVPPAVPGVTFLSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAAQEEYIKRALANSLACQGKYTPSGQSGAAASESLFISNHAY
uniprot
proteins
ec_number
4.1.2.13
uniprot
proteins
function
FUNCTION: Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis. In addition, also functions as a scaffolding protein. In response to glucose deprivation, FBP dissociates from aldolase and acts as an adapter that promotes AMP-activated protein kinase (AMPK) activity: mechanistically, associates with transient receptor potential channels TrpV (TRPV1-TRPV4), promoting inhibition of the V-ATPase complex on lysosomes and AMPK activation via the AXIN1-STK11/LKB1 axis. {ECO:0000250|UniProtKB:P05064}.
uniprot
proteins
mass_dalton
39352
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-39 in response to beta-arrestin-1 (ARRB1) signaling, promoting the fructose-bisphosphate aldolase activity, leading to enhanced glycolysis and improved glucose tolerance. {ECO:0000250|UniProtKB:P05064}.
uniprot
proteins
protein_family
Class I fructose-bisphosphate aldolase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2416636
uniprot
proteins
pubmed
3753977
uniprot
proteins
pubmed
3783705
uniprot
proteins
pubmed
6086339
uniprot
proteins
sequence_length
364
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, I band {ECO:0000250|UniProtKB:P00883}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250|UniProtKB:P00883}. Note=In skeletal muscle, accumulates around the M line and within the I band, colocalizing with FBP2 on both sides of the Z line in the absence of Ca(2+). {ECO:0000250|UniProtKB:P00883}.
uniprot
proteins