APOOL
entrez
139322
canonical
uniprot
Q6UXV4
canonical
ensembl
ENSG00000155008
resolver
ensp
ENSP00000362268
resolver
ensp
ENSP00000565567
resolver
enst
ENST00000373173
resolver
genesymbol
APOOL
resolver
genesymbol_syn
CXorf33
resolver
genesymbol_syn
FAM121A
resolver
genesymbol_syn
MIC27
resolver
hgnc
HGNC:24009
resolver
uniprot
Q3KNU7
resolver
uniprot
Q5H9D1
resolver
uniprot_entry
MIC27_HUMAN
resolver
uniprot_sec
Q3KNU7
resolver
uniprot_sec
Q5H9D1
resolver
amino_acid_sequence
MAAIRMGKLTTMPAGLIYASVSVHAAKQEESKKQLVKPEQLPIYTAPPLQSKYVEEQPGHLQMGFASIRTATGCYIGWCKGVYVFVKNGIMDTVQFGKDAYVYLKNPPRDFLPKMGVITVSGLAGLVSARKGSKFKKITYPLGLATLGATVCYPVQSVIIAKVTAKKVYATSQQIFGAVKSLWTKSSKEESLPKPKEKTKLGSSSEIEVPAKTTHVLKHSVPLPTELSSEAKTKSESTSGATQFMPDPKLMDHGQSHPEDIDMYSTRS
uniprot
proteins
function
FUNCTION: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:23704930), (PubMed:25764979). {ECO:0000269|PubMed:23704930, ECO:0000269|PubMed:25764979}.
uniprot
proteins
mass_dalton
29159
uniprot
proteins
protein_family
Apolipoprotein O/MICOS complex subunit Mic27 family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23704930
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24687277
uniprot
proteins
pubmed
25764979
uniprot
proteins
pubmed
25781180
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
25997101
uniprot
proteins
sequence_length
268
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:23704930, ECO:0000269|PubMed:25764979}; Multi-pass membrane protein {ECO:0000269|PubMed:23704930}. Mitochondrion {ECO:0000269|PubMed:25781180, ECO:0000269|PubMed:25997101}.
uniprot
proteins
transmembrane_region
TRANSMEM 111..129; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 138..155; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins