ASTN2
entrez
23245
canonical
uniprot
O75129
canonical
ensembl
ENSG00000148219
resolver
ensp
ENSP00000288520
resolver
ensp
ENSP00000314038
resolver
ensp
ENSP00000339925
resolver
ensp
ENSP00000351460
resolver
ensp
ENSP00000354504
resolver
ensp
ENSP00000679720
resolver
enst
ENST00000358637
resolver
genesymbol
ASTN2
resolver
genesymbol_syn
KIAA0634
resolver
hgnc
HGNC:17021
resolver
uniprot
A2A2T7
resolver
uniprot
A2A2T9
resolver
uniprot
B3KN99
resolver
uniprot
B7ZKP4
resolver
uniprot
B7ZKP5
resolver
uniprot
Q52LQ2
resolver
uniprot
Q5JVX8
resolver
uniprot
Q5JVX9
resolver
uniprot
Q5JVY1
resolver
uniprot
Q5VXG8
resolver
uniprot
Q5VZX6
resolver
uniprot
Q8N6P8
resolver
uniprot
Q8WV47
resolver
uniprot
Q96FL4
resolver
uniprot
Q9UHW6
resolver
uniprot
X6R5P2
resolver
uniprot_entry
ASTN2_HUMAN
resolver
uniprot_entry
B3KN99_HUMAN
resolver
uniprot_entry
B7ZKP4_HUMAN
resolver
uniprot_entry
B7ZKP5_HUMAN
resolver
uniprot_entry
X6R5P2_HUMAN
resolver
uniprot_sec
A2A2T7
resolver
uniprot_sec
A2A2T9
resolver
uniprot_sec
Q52LQ2
resolver
uniprot_sec
Q5JVX8
resolver
uniprot_sec
Q5JVX9
resolver
uniprot_sec
Q5JVY1
resolver
uniprot_sec
Q5VXG8
resolver
uniprot_sec
Q5VZX6
resolver
uniprot_sec
Q8N6P8
resolver
uniprot_sec
Q8WV47
resolver
uniprot_sec
Q96FL4
resolver
uniprot_sec
Q9UHW6
resolver
amino_acid_sequence
MAAAGARLSPGPGSGLRGRPRLCFHPGPPPLLPLLLLFLLLLPPPPLLAGATAAASREPDSPCRLKTVTVSTLPALRESDIGWSGARAGAGAGTGAGAAAAAASPGSPGSAGTAAESRLLLFVRNELPGRIAVQDDLDNTELPFFTLEMSGTAADISLVHWRQQWLENGTLYFHVSMSSSGQLAQATAPTLQEPSEIVEEQMHILHISVMGGLIALLLLLLVFTVALYAQRRWQKRRRIPQKSASTEATHEIHYIPSVLLGPQARESFRSSRLQTHNSVIGVPIRETPILDDYDCEEDEEPPRRANHVSREDEFGSQVTHTLDSLGHPGEEKVDFEKKAAAEATQETVESLMQKFKESFRANTPIEIGQLQPPLRSTSAGKRKRRSKSRGGISFGRAKGTSGSEADDETQLTFYTEQYRSRRRSKGLLKSPVNKTALTLIAVSSCILAMVCGSQMSCPLTVKVTLHVPEHFIADGSSFVVSEGSYLDISDWLNPAKLSLYYQINATSPWVRDLCGQRTTDACEQLCDPETGECSCHEGYAPDPVHRHLCVRSDWGQSEGPWPYTTLERGYDLVTGEQAPEKILRSTFSLGQGLWLPVSKSFVVPPVELSINPLASCKTDVLVTEDPADVREEAMLSTYFETINDLLSSFGPVRDCSRNNGGCTRNFKCVSDRQVDSSGCVCPEELKPMKDGSGCYDHSKGIDCSDGFNGGCEQLCLQQTLPLPYDATSSTIFMFCGCVEEYKLAPDGKSCLMLSDVCEGPKCLKPDSKFNDTLFGEMLHGYNNRTQHVNQGQVFQMTFRENNFIKDFPQLADGLLVIPLPVEEQCRGVLSEPLPDLQLLTGDIRYDEAMGYPMVQQWRVRSNLYRVKLSTITLAAGFTNVLKILTKESSREELLSFIQHYGSHYIAEALYGSELTCIIHFPSKKVQQQLWLQYQKETTELGSKKELKSMPFITYLSGLLTAQMLSDDQLISGVEIRCEEKGRCPSTCHLCRRPGKEQLSPTPVLLEINRVVPLYTLIQDNGTKEAFKSALMSSYWCSGKGDVIDDWCRCDLSAFDANGLPNCSPLLQPVLRLSPTVEPSSTVVSLEWVDVQPAIGTKVSDYILQHKKVDEYTDTDLYTGEFLSFADDLLSGLGTSCVAAGRSHGEVPEVSIYSVIFKCLEPDGLYKFTLYAVDTRGRHSELSTVTLRTACPLVDDNKAEEIADKIYNLYNGYTSGKEQQMAYNTLMEVSASMLFRVQHHYNSHYEKFGDFVWRSEDELGPRKAHLILRRLERVSSHCSSLLRSAYIQSRVETVPYLFCRSEEVRPAGMVWYSILKDTKITCEEKMVSMARNTYGESKGR
uniprot
proteins
function
FUNCTION: Mediates recycling of the neuronal cell adhesion molecule ASTN1 to the anterior pole of the cell membrane in migrating neurons. Promotes ASTN1 internalization and intracellular transport of endocytosed ASTN1 (By similarity). Selectively binds inositol-4,5-bisphosphate, inositol-3,4,5-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, suggesting it is recruited to membranes that contain lipids with a phosphoinositide headgroup (Ref.6). {ECO:0000250|UniProtKB:Q80Z10, ECO:0000269|Ref.6}.
uniprot
proteins
mass_dalton
148243
uniprot
proteins
mutagenesis
MUTAGEN 1175; /note="R->T: Abolishes inositol-4,5-bisphosphate binding. Strongly reduces affinity for inositol-3,4,5-trisphosphate."; /evidence="ECO:0000269|Ref.6
uniprot
proteins
protein_family
Astrotactin family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
21248752
uniprot
proteins
pubmed
28940097
uniprot
proteins
pubmed
29288388
uniprot
proteins
pubmed
9734811
uniprot
proteins
sequence_length
1339
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q80Z10}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q80Z10}. Perikaryon {ECO:0000250|UniProtKB:Q80Z10}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q80Z10}. Early endosome {ECO:0000250|UniProtKB:Q80Z10}. Late endosome {ECO:0000250|UniProtKB:Q80Z10}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q80Z10}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q80Z10}. Note=Integral membrane protein not detected at the cell membrane. Detected in cytoplasmic vesicles in the cell cortex, close to the anterior pole of migrating neurons. Detected at the base of the leading process in migrating neurons. {ECO:0000250|UniProtKB:Q80Z10}.
uniprot
proteins
transmembrane_region
TRANSMEM 207..227; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 435..455; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins