SEC61B
entrez
10952
canonical
uniprot
P60468
canonical
ensembl
ENSG00000106803
resolver
ensp
ENSP00000223641
resolver
enst
ENST00000223641
resolver
genesymbol
SEC61B
resolver
hgnc
HGNC:16993
resolver
uniprot
P38390
resolver
uniprot
P38391
resolver
uniprot
Q6IBC1
resolver
uniprot_entry
SC61B_HUMAN
resolver
uniprot_sec
P38390
resolver
uniprot_sec
P38391
resolver
uniprot_sec
Q6IBC1
resolver
amino_acid_sequence
MPGPTPSGTNVGSSGRSPSKAVAARAAGSTVRQRKNASCGTRSAGRTTSAGTGGMWRFYTEDSPGLKVGPVPVLVMSLLFIASVFMLHIWGKYTRS
uniprot
proteins
disease_involvement
DISEASE: Note=Loss-of-function SEC61B variations may cause autosomal dominant polycystic liver disease (PCLD) in patients that lack variations in known causative genes, such as PRKCSH and SEC63. {ECO:0000305|PubMed:28375157}.
uniprot
proteins
function
FUNCTION: Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (PubMed:12475939). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (PubMed:12475939). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (PubMed:32820719, PubMed:36261522). The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (PubMed:19121997). {ECO:0000269|PubMed:12475939, ECO:0000269|PubMed:19121997, ECO:0000269|PubMed:32820719, ECO:0000269|PubMed:36261522}.
uniprot
proteins
mass_dalton
9974
uniprot
proteins
mutagenesis
MUTAGEN 39; /note="C->S: Abolishes S-acylation."; /evidence="ECO:0000269|PubMed:21044946
uniprot
proteins
protein_family
SEC61-beta family
uniprot
proteins
pubmed
12475939
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19121997
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21044946
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27044890
uniprot
proteins
pubmed
28375157
uniprot
proteins
pubmed
32820719
uniprot
proteins
pubmed
36261522
uniprot
proteins
pubmed
36697828
uniprot
proteins
pubmed
8107851
uniprot
proteins
sequence_length
96
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12475939, ECO:0000269|PubMed:27044890}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 71..91; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins