ADAM19
entrez
8728
canonical
uniprot
Q9H013
canonical
ensembl
ENSG00000135074
resolver
ensp
ENSP00000257527
resolver
ensp
ENSP00000428654
resolver
genesymbol
ADAM19
resolver
genesymbol_syn
MLTNB
resolver
hgnc
HGNC:197
resolver
uniprot
Q8N504
resolver
uniprot
Q8TBU7
resolver
uniprot
Q9BZL5
resolver
uniprot
Q9UHP2
resolver
uniprot_entry
ADA19_HUMAN
resolver
uniprot_entry
Q8TBU7_HUMAN
resolver
uniprot_sec
Q8N504
resolver
uniprot_sec
Q9BZL5
resolver
uniprot_sec
Q9UHP2
resolver
amino_acid_sequence
MPGGAGAARLCLLAFALQPLRPRAAREPGWTRGSEEGSPKLQHELIIPQWKTSESPVREKHPLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHCFYHGTVRETELSSVTLSTCRGIRGLITVSSNLSYVIEPLPDSKGQHLIYRSEHLKPPPGNCGFEHSKPTTRDWALQFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQDATKHKLIEIANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRRKLLAQKYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHDSADCCSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLYGGRRCGNGYLEDGEECDCGEEEECNNPCCNASNCTLRPGAECAHGSCCHQCKLLAPGTLCREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGARPAPDLCFEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARPLESNAVPIDTTIIMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETEGCGKKCNGHGVCNNNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAILVLAVLMLMYYCCRQNNKLGQLKPSALPSKLRQQFSCPFRVSQNSGTGHANPTFKLQTPQGKRKVINTPEILRKPSQPPPRPPPDYLRGGSPPAPLPAHLSRAARNSPGPGSQIERTESSRRPPPSRPIPPAPNCIVSQDFSRPRPPQKALPANPVPGRRSLPRPGGASPLRPPGAGPQQSRPLAALAPKVSPREALKVKAGTRGLQGGRCRVEKTKQFMLLVVWTELPEQKPRAKHSCFLVPA
uniprot
proteins
ec_number
3.4.24.-
uniprot
proteins
function
FUNCTION: Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
104997
uniprot
proteins
post_translational_modification
PTM: The precursor is cleaved by a furin endopeptidase. {ECO:0000250}.
uniprot
proteins
pubmed
10887142
uniprot
proteins
pubmed
11162584
uniprot
proteins
pubmed
12615925
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
18772397
uniprot
proteins
sequence_length
955
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 700..720; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins