Alg11
entrez
207958
canonical
uniprot
Q3TZM9
canonical
ensembl
ENSMUSG00000063362
resolver
ensp
ENSMUSP00000072382
resolver
ensp
ENSMUSP00000106365
resolver
genesymbol
Alg11
resolver
genesymbol_syn
Mmat-4(5)
resolver
uniprot
A0A077K846
resolver
uniprot
Q6P7W8
resolver
uniprot
Q8BL38
resolver
uniprot_entry
A0A077K846_MOUSE
resolver
uniprot_entry
ALG11_MOUSE
resolver
uniprot_sec
Q6P7W8
resolver
uniprot_sec
Q8BL38
resolver
amino_acid_sequence
MAADTGSWCVYAVLRFFYSLFFPGLMICGVLCVYLVIGLWVIRWHLQRKKKSVSTSKNGKEQTVVAFFHPYCNAGGGGERVLWCALRALQKKYPEAVYVVYTGDINVSGQQILDGAFRRFNIKLAHPVQFVFLRKRYLVEDSRYPHFTLLGQSLGSILLGWEALMQRVPDVYIDSMGYAFTLPLFKYVGGCRVGSYVHYPTISTDMLSVVKNQNPGFNNAAFISRNALLSKAKLIYYYLFAFVYGLVGSCSDIVMVNSSWTLNHILSLWKVGHCTNIVYPPCDVQTFLDIPLHEKKVTPGHLLVSIGQFRPEKNHALQIKAFAKLLNEKAAELGHSLKLVLIGGCRNKDDEFRVNQLRSLSENLGVQENVEFKINISFDELKNYLSEATIGLHTMWNEHFGIGVVECMAAGTVILAHNSGGPKLDIVIPHEGQITGFLAESEEGYADSMAHILSLSAEERLQIRKNARASISRFSDQEFEVAFLCSMEKLLT
uniprot
proteins
ec_number
2.4.1.131
uniprot
proteins
function
FUNCTION: GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes, on the cytoplasmic face of the endoplasmic reticulum, the addition of the fourth and fifth mannose residues to the dolichol-linked oligosaccharide chain, to produce Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide. Man(5)GlcNAc(2)-PP-dolichol is a substrate for ALG3, the following enzyme in the biosynthetic pathway. {ECO:0000250|UniProtKB:Q2TAA5}.
uniprot
proteins
mass_dalton
55270
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:Q2TAA5}.
uniprot
proteins
protein_family
Glycosyltransferase 4 subfamily
uniprot
proteins
protein_family
Glycosyltransferase group 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
492
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q2TAA5}; Single-pass membrane protein {ECO:0000250|UniProtKB:P53954}.
uniprot
proteins
transmembrane_region
TRANSMEM 20..40; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins