CRIPTO
entrez
6997
canonical
uniprot
P13385
canonical
ensembl
ENSG00000241186
resolver
ensp
ENSP00000296145
resolver
ensp
ENSP00000446375
resolver
ensp
ENSP00000533441
resolver
ensp
ENSP00000608364
resolver
ensp
ENSP00000608365
resolver
ensp
ENSP00000608369
resolver
enst
ENST00000296145
resolver
enst
ENST00000542931
resolver
enst
ENST00000863382
resolver
enst
ENST00000938305
resolver
enst
ENST00000938306
resolver
enst
ENST00000938310
resolver
genesymbol
CRIPTO
resolver
genesymbol_syn
CRIPTO-1
resolver
genesymbol_syn
TDGF1
resolver
hgnc
HGNC:11701
resolver
uniprot
F5H1T8
resolver
uniprot
Q8TCC1
resolver
uniprot_entry
F5H1T8_HUMAN
resolver
uniprot_entry
TDGF1_HUMAN
resolver
uniprot_sec
Q8TCC1
resolver
amino_acid_sequence
MDCRKMARFSYSVIWIMAISKVFELGLVAGLGHQEFARPSRGYLAFRDDSIWPQEEPAIRPRSSQRVPPMGIQHSKELNRTCCLNGGTCMLGSFCACPPSFYGRNCEHDVRKENCGSVPHDTWLPKKCSLCKCWHGQLRCFPQAFLPGCDGLVMDEHLVASRTPELPPSARTTTFMLVGICLSIQSYY
uniprot
proteins
function
FUNCTION: GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated CRIPTO acts as a Nodal coreceptor in cis. Shedding of CRIPTO by TMEM8A modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells (PubMed:27881714). Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm (PubMed:11909953). {ECO:0000269|PubMed:11909953, ECO:0000269|PubMed:27881714}.
uniprot
proteins
mass_dalton
21169
uniprot
proteins
mutagenesis
MUTAGEN 188; /note="Y->YVVVVV: Alters the localization and decreases the biological activity."; /evidence="ECO:0000269|PubMed:18930707
uniprot
proteins
post_translational_modification
PTM: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, it is processed by GPI processing phospholipase A2 (TMEM8A), removing an acyl-chain at the sn-2 position of GPI and releasing CRIPTO as a lysophosphatidylinositol-bearing form, which is further cleaved by phospholipase D (GPLD1) into a soluble form. {ECO:0000269|PubMed:27881714}.
uniprot
proteins
protein_family
EGF-CFC (Cripto-1/FRL1/Cryptic) family
uniprot
proteins
pubmed
11909953
uniprot
proteins
pubmed
12919325
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
1882841
uniprot
proteins
pubmed
18835250
uniprot
proteins
pubmed
18930707
uniprot
proteins
pubmed
27881714
uniprot
proteins
pubmed
2792079
uniprot
proteins
sequence_length
188
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18930707, ECO:0000269|PubMed:27881714}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:18930707, ECO:0000269|PubMed:27881714}. Secreted {ECO:0000269|PubMed:27881714}. Note=Released from the cell membrane by GPI cleavage. {ECO:0000269|PubMed:27881714}.
uniprot
proteins