PGP
entrez
283871
canonical
uniprot
A6NDG6
canonical
ensembl
ENSG00000184207
resolver
ensp
ENSP00000330918
resolver
enst
ENST00000333503
resolver
genesymbol
PGP
resolver
hgnc
HGNC:8909
resolver
uniprot_entry
PGP_HUMAN
resolver
amino_acid_sequence
MAAAEAGGDDARCVRLSAERAQALLADVDTLLFDCDGVLWRGETAVPGAPEALRALRARGKRLGFITNNSSKTRAAYAEKLRRLGFGGPAGPGASLEVFGTAYCTALYLRQRLAGAPAPKAYVLGSPALAAELEAVGVASVGVGPEPLQGEGPGDWLHAPLEPDVRAVVVGFDPHFSYMKLTKALRYLQQPGCLLVGTNMDNRLPLENGRFIAGTGCLVRAVEMAAQRQADIIGKPSRFIFDCVSQEYGINPERTVMVGDRLDTDILLGATCGLKTILTLTGVSTLGDVKNNQESDCVSKKKMVPDFYVDSIADLLPALQG
uniprot
proteins
ec_number
3.1.3.18
uniprot
proteins
ec_number
3.1.3.21
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Phosphatase with activity against multiple substrates (PubMed:27294321). Acts as a metabolite repair enzyme which eliminates toxic glycolytic side products (PubMed:27294321). Dephosphorylates 2-phosphoglycolate which is generated during the repair of oxidative DNA lesions (PubMed:26755581, PubMed:27294321). This controls triosephosphate isomerase activity, glycerolipid partitioning and cell proliferation in the embryo and is required for embryonic development (By similarity). Dephosphorylates 4-phosphoerythronate, a side product which is produced by GAPDH and which inhibits 6-phosphogluconate dehydrogenase (PubMed:27294321). Dephosphorylation of 4-phosphoerythronate prevents the accumulation of high 4-phosphoerythronate levels which would otherwise inhibit the pentose phosphate pathway (PubMed:27294321). Dephosphorylates 2-phospho-L-lactate which is a product of a pyruvate kinase side reaction (PubMed:27294321). This prevents the inhibition of fructose-2,6-bisphosphate production and allows glycolysis to occur (PubMed:27294321). Has glycerol-3-phosphate phosphatase activity, hydrolyzing glycerol-3-phosphate into glycerol and thereby regulating the cellular levels of glycerol-3-phosphate, a metabolic intermediate of glucose, lipid and energy metabolism (PubMed:26755581). Has been shown to have tyrosine-protein phosphatase activity although the physiological relevance is unclear (PubMed:26755581). In vitro, has phosphatase activity toward ADP, ATP, GDP and GTP (By similarity). {ECO:0000250|UniProtKB:Q8CHP8, ECO:0000269|PubMed:26755581, ECO:0000269|PubMed:27294321}.
uniprot
proteins
mass_dalton
34006
uniprot
proteins
protein_family
CbbY/CbbZ/Gph/YieH family
uniprot
proteins
protein_family
HAD-like hydrolase superfamily
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
215071
uniprot
proteins
pubmed
26755581
uniprot
proteins
pubmed
27294321
uniprot
proteins
sequence_length
321
uniprot
proteins