TGFB1I1
entrez
7041
canonical
uniprot
O43294
canonical
ensembl
ENSG00000140682
resolver
ensp
ENSP00000355117
resolver
ensp
ENSP00000378327
resolver
ensp
ENSP00000378332
resolver
genesymbol
TGFB1I1
resolver
genesymbol_syn
ARA55
resolver
hgnc
HGNC:11767
resolver
uniprot
B2R8D5
resolver
uniprot
Q9BPW3
resolver
uniprot
Q9Y2V5
resolver
uniprot_entry
TGFI1_HUMAN
resolver
uniprot_sec
B2R8D5
resolver
uniprot_sec
Q9BPW3
resolver
uniprot_sec
Q9Y2V5
resolver
amino_acid_sequence
MEDLDALLSDLETTTSHMPRSGAPKERPAEPLTPPPSYGHQPQTGSGESSGASGDKDHLYSTVCKPRSPKPAAPAAPPFSSSSGVLGTGLCELDRLLQELNATQFNITDEIMSQFPSSKVASGEQKEDQSEDKKRPSLPSSPSPGLPKASATSATLELDRLMASLSDFRVQNHLPASGPTQPPVVSSTNEGSPSPPEPTGKGSLDTMLGLLQSDLSRRGVPTQAKGLCGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLFG
uniprot
proteins
function
FUNCTION: Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. {ECO:0000269|PubMed:10075738, ECO:0000269|PubMed:11463817, ECO:0000269|PubMed:11856738, ECO:0000269|PubMed:12177201, ECO:0000269|PubMed:12445807, ECO:0000269|PubMed:12700349, ECO:0000269|PubMed:15211577, ECO:0000269|PubMed:15561701, ECO:0000269|PubMed:16141357, ECO:0000269|PubMed:16624805, ECO:0000269|PubMed:16803896, ECO:0000269|PubMed:16849583, ECO:0000269|PubMed:17166536, ECO:0000269|PubMed:17233630, ECO:0000269|PubMed:9032249}.
uniprot
proteins
mass_dalton
49814
uniprot
proteins
mutagenesis
MUTAGEN 60; /note="Y->F: Prevents phosphorylation by FAK2 and FYN. Prevents interaction with CSK."; /evidence="ECO:0000269|PubMed:10838081"; MUTAGEN 287; /note="C->A: Abolishes interaction with CBLC and enhancement of CBLCE3 ubiquitin-protein ligase activity."; /evidence="ECO:0000269|PubMed:23145173"; MUTAGEN 313; /note="C->A: No effect on interaction with CBLC."; /evidence="ECO:0000269|PubMed:23145173"; MUTAGEN 338..342; /note="FLQLF->ALQAA: Loss of interaction with AR; when associated with 456-A--A-460."; /evidence="ECO:0000269|PubMed:12714604"; MUTAGEN 369; /note="C->S: Loss of AR coactivation; when associated with S-372."; /evidence="ECO:0000269|PubMed:16624805"; MUTAGEN 372; /note="C->S: Loss of AR coactivation; when associated with S-369."; /evidence="ECO:0000269|PubMed:16624805"; MUTAGEN 428; /note="H->S: Loss of AR coactivation; when associated with S-431."; /evidence="ECO:0000269|PubMed:16624805"; MUTAGEN 431; /note="C->S: Loss of AR coactivation; when associated with S-428."; /evidence="ECO:0000269|PubMed:16624805"; MUTAGEN 456..460; /note="FLKLF->ALKAA: Loss of interaction with AR; when associated with 338-A--A-342."; /evidence="ECO:0000269|PubMed:12714604
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by gonadotropin-releasing hormone-activated SRC. {ECO:0000269|PubMed:10838081, ECO:0000269|PubMed:11311131, ECO:0000269|PubMed:11856738, ECO:0000269|PubMed:17202804, ECO:0000269|PubMed:17233630}.
uniprot
proteins
protein_family
Paxillin family
uniprot
proteins
pubmed
10075738
uniprot
proteins
pubmed
10708479
uniprot
proteins
pubmed
10838081
uniprot
proteins
pubmed
11311131
uniprot
proteins
pubmed
11313252
uniprot
proteins
pubmed
11463817
uniprot
proteins
pubmed
11489729
uniprot
proteins
pubmed
11532379
uniprot
proteins
pubmed
11856738
uniprot
proteins
pubmed
12153727
uniprot
proteins
pubmed
12177201
uniprot
proteins
pubmed
12445807
uniprot
proteins
pubmed
12631731
uniprot
proteins
pubmed
12642630
uniprot
proteins
pubmed
12700349
uniprot
proteins
pubmed
12714604
uniprot
proteins
pubmed
12772188
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15211577
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15561701
uniprot
proteins
pubmed
15687259
uniprot
proteins
pubmed
16141357
uniprot
proteins
pubmed
16330715
uniprot
proteins
pubmed
16624805
uniprot
proteins
pubmed
16803896
uniprot
proteins
pubmed
16849583
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17166536
uniprot
proteins
pubmed
17202804
uniprot
proteins
pubmed
17233630
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23145173
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9032249
uniprot
proteins
pubmed
9422762
uniprot
proteins
pubmed
9664039
uniprot
proteins
pubmed
9756887
uniprot
proteins
sequence_length
461
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, focal adhesion. Nucleus matrix. Cytoplasm, cytoskeleton. Note=Associated with the actin cytoskeleton; colocalizes with stress fibers.
uniprot
proteins