Elovl2
entrez
498728
canonical
uniprot
D4A612
canonical
ensembl
ENSRNOG00000014702
resolver
ensembl
ENSRNOG00055007448
resolver
ensembl
ENSRNOG00060008946
resolver
ensembl
ENSRNOG00065008205
resolver
ensp
ENSRNOP00000091242
resolver
ensp
ENSRNOP00000097102
resolver
ensp
ENSRNOP00055009866
resolver
ensp
ENSRNOP00060011653
resolver
ensp
ENSRNOP00065009577
resolver
enst
ENSRNOT00000115567
resolver
enst
ENSRNOT00055012430
resolver
enst
ENSRNOT00060015021
resolver
enst
ENSRNOT00065012996
resolver
genesymbol
Elovl2
resolver
genesymbol_syn
ELOVL2
resolver
genesymbol_syn
Ssc2
resolver
uniprot
A0A8I6B5B4
resolver
uniprot_entry
A0A8I6B5B4_RAT
resolver
uniprot_entry
ELOV2_RAT
resolver
amino_acid_sequence
MFGPRDSRVRGWFLLDSYLPTFTLTIVYLLSIWLGNKYMKNRPALSLRGILTLYNLGITLLSAYMLVELVLSSWEGGYNLQCQNLDSAGEGDIRVAKVLWWYYFSKLVEFLDTIFFVLRKKTSQITFLHVYHHASMFNIWWCVLNWIPCGQSFFGPTLNSFIHILMYSYYGLSVFPSMHRYLWWKKYLTQAQLVQFVLTITHTLSAVVKPCGFPFGCLIFQSSYMMTLVILFLNFYIQTYRKKPMKKEMPEGAAGKEVKNGFPKAHSIAANGVTDKKVQ
uniprot
proteins
ec_number
2.3.1.199
uniprot
proteins
function
FUNCTION: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA), acting specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. May participate in the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000255|HAMAP-Rule:MF_03202, ECO:0000269|PubMed:22216341, ECO:0000269|PubMed:23873268}.
uniprot
proteins
mass_dalton
32417
uniprot
proteins
mutagenesis
MUTAGEN 217; /note="C->A: Decreased elongase activity toward (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA."; /evidence="ECO:0000269|PubMed:23873268"; MUTAGEN 217; /note="C->F: Decreased elongase activity toward (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA."; /evidence="ECO:0000269|PubMed:23873268"; MUTAGEN 217; /note="C->W: Loss of elongase activity toward (7Z,10Z,13Z,16Z,19Z)-docosapentaenoyl-CoA."; /evidence="ECO:0000269|PubMed:23873268
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; polyunsaturated fatty acid biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03202, ECO:0000269|PubMed:22216341, ECO:0000269|PubMed:23873268}.
uniprot
proteins
protein_family
ELO family
uniprot
proteins
protein_family
ELOVL2 subfamily
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22216341
uniprot
proteins
pubmed
23873268
uniprot
proteins
sequence_length
279
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03202}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03202}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03202"; TRANSMEM 50..70; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03202"; TRANSMEM 98..118; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03202"; TRANSMEM 136..156; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03202"; TRANSMEM 158..178; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03202"; TRANSMEM 188..208; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03202"; TRANSMEM 213..233; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03202
uniprot
proteins