Jpt1
entrez
287828
canonical
uniprot
Q6AXU6
canonical
ensembl
ENSRNOG00000003661
resolver
ensembl
ENSRNOG00055033143
resolver
ensembl
ENSRNOG00060031546
resolver
ensembl
ENSRNOG00065022159
resolver
ensp
ENSRNOP00000004862
resolver
ensp
ENSRNOP00055047205
resolver
ensp
ENSRNOP00060045199
resolver
ensp
ENSRNOP00065030524
resolver
enst
ENSRNOT00000004862
resolver
enst
ENSRNOT00055057270
resolver
enst
ENSRNOT00060054664
resolver
enst
ENSRNOT00065037750
resolver
genesymbol
Jpt1
resolver
genesymbol_syn
Hn1
resolver
uniprot
A0A059NZR0
resolver
uniprot_entry
A0A059NZR0_RAT
resolver
uniprot_entry
JUPI1_RAT
resolver
amino_acid_sequence
MTTTTTFKGVDPNSRNSSRVLRPPGGGSNFSLGFDEPTEQPVRKNKMASNIFGTPEENPPSWAKSAGGREDSESPGTQRSNSSEASSGDFLDLKGESDVHENVDTDFQASLAQVEEKPVPAAPVPSPVAPAPAPSRRNPPGGKSSLVLG
uniprot
proteins
function
FUNCTION: Modulates negatively AKT-mediated GSK3B signaling. Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions. Plays a role in the regulation of cell cycle and cell adhesion. Has an inhibitory role on AR-signaling pathway through the induction of receptor proteasomal degradation. {ECO:0000250|UniProtKB:Q9UK76}.
uniprot
proteins
mass_dalton
15575
uniprot
proteins
protein_family
JUPITER family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
149
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UK76}. Cytoplasm {ECO:0000250|UniProtKB:Q9UK76}.
uniprot
proteins