TRIM4
entrez
89122
canonical
uniprot
Q9C037
canonical
ensembl
ENSG00000146833
resolver
ensp
ENSP00000275736
resolver
ensp
ENSP00000348216
resolver
genesymbol
TRIM4
resolver
genesymbol_syn
RNF87
resolver
hgnc
HGNC:16275
resolver
uniprot
A4D298
resolver
uniprot
Q75MK1
resolver
uniprot
Q96F06
resolver
uniprot
Q9C036
resolver
uniprot_entry
TRIM4_HUMAN
resolver
uniprot_sec
A4D298
resolver
uniprot_sec
Q75MK1
resolver
uniprot_sec
Q96F06
resolver
uniprot_sec
Q9C036
resolver
amino_acid_sequence
MEAEDIQEELTCPICLDYFQDPVSIECGHNFCRGCLHRNWAPGGGPFPCPECRHPSAPAALRPNWALARLTEKTQRRRLGPVPPGLCGRHWEPLRLFCEDDQRPVCLVCRESQEHQTHAMAPIDEAFESYRTGNFDIHVDEWKRRLIRLLLYHFKQEEKLLKSQRNLVAKMKKVMHLQDVEVKNATQWKDKIKSQRMRISTEFSKLHNFLVEEEDLFLQRLNKEEEETKKKLNENTLKLNQTIASLKKLILEVGEKSQAPTLELLQNPKEVLTRSEIQDVNYSLEAVKVKTVCQIPLMKEMLKRFQVAVNLAEDTAHPKLVFSQEGRYVKNTASASSWPVFSSAWNYFAGWRNPQKTAFVERFQHLPCVLGKNVFTSGKHYWEVESRDSLEVAVGVCREDVMGITDRSKMSPDVGIWAIYWSAAGYWPLIGFPGTPTQQEPALHRVGVYLDRGTGNVSFYSAVDGVHLHTFSCSSVSRLRPFFWLSPLASLVIPPVTDRK
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase. Mediates 'Lys-63'-linked polyubiquitination of the innate immune receptor RIGI, this linkage doesn't lead to proteasomal degradation but seems to enhance IFN induction. {ECO:0000269|PubMed:24755855}.
uniprot
proteins
mass_dalton
57461
uniprot
proteins
mutagenesis
MUTAGEN 27; /note="C->S: Abolishes ligase activity."; /evidence="ECO:0000269|PubMed:24755855
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
11331580
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17156811
uniprot
proteins
pubmed
24755855
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
500
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17156811}.
uniprot
proteins