MEIKIN
entrez
728637
canonical
uniprot
A0A087WXM9
canonical
ensembl
ENSG00000239642
resolver
ensp
ENSP00000488568
resolver
enst
ENST00000442687
resolver
genesymbol
MEIKIN
resolver
hgnc
HGNC:51253
resolver
uniprot
A0A0A8IBZ9
resolver
uniprot_entry
MEIKN_HUMAN
resolver
uniprot_sec
A0A0A8IBZ9
resolver
amino_acid_sequence
MWPLRVYTRKKREGQRLNLTPTPDLGSPAKAEAPPGSKRKGKVHGLSKIAEKAERSRQGGSGSGPFSPRLGVTGEKSLQENRSSEDTQDEKIASLRESVTDDLQVDSSSSNSELVSGLSLHHGMASSLLSYSVTDSYAEYKSFEESFPSPELFRKSDYLDWECPNLEEHMQWKNSTLLDTSKAVAIEKAPQFSNVSAIFSTSSEDYQKCHRKTVMTVADQNVSPKAKCASNSESDNAACEILLAEKTCPSTPEKTKKKKTNSSTPGKKNRGLLTSTPSSETAGFVIDLSSVQKASFEELFPNVSNYVNSNEIVPVSSLQENSSNEFPANASEICCIIRTSPGTRQVKNKGVIVKKKKYSLPKDTPQDIIIKMA
uniprot
proteins
function
FUNCTION: Key regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage. Acts by facilitating kinetochore mono-orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Also required to prevent cleavage of cohesin at centromeres during meiosis I, possibly by acting as a regulator of the shugoshin-dependent protection pathway. Acts in collaboration with PLK1: required for PLK1 enrichment to kinetochores. Not required during meiosis II or mitosis. {ECO:0000250|UniProtKB:Q5F2C3}.
uniprot
proteins
mass_dalton
40829
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
25533956
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome, centromere {ECO:0000250|UniProtKB:Q5F2C3}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q5F2C3}. Note=Localizes at kinetochores in meiosis I but undetectable in meiosis II. {ECO:0000250|UniProtKB:Q5F2C3}.
uniprot
proteins