PLN
entrez
5350
canonical
uniprot
P26678
canonical
ensembl
ENSG00000198523
resolver
ensp
ENSP00000350132
resolver
ensp
ENSP00000545783
resolver
ensp
ENSP00000545784
resolver
ensp
ENSP00000545785
resolver
ensp
ENSP00000545786
resolver
ensp
ENSP00000624019
resolver
enst
ENST00000357525
resolver
enst
ENST00000875724
resolver
enst
ENST00000875725
resolver
enst
ENST00000875726
resolver
enst
ENST00000875727
resolver
enst
ENST00000953960
resolver
genesymbol
PLN
resolver
genesymbol_syn
PLB
resolver
hgnc
HGNC:9080
resolver
uniprot
Q5R352
resolver
uniprot_entry
PPLA_HUMAN
resolver
uniprot_entry
Q5R352_HUMAN
resolver
amino_acid_sequence
MEKVQYLTRSAIRRASTIEMPQQARQKLQNLFINFCLILICLLLICIIVMLL
uniprot
proteins
disease_involvement
DISEASE: Cardiomyopathy, dilated, 1P (CMD1P) [MIM:609909]: A disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. {ECO:0000269|PubMed:12610310, ECO:0000269|PubMed:16432188, ECO:0000269|PubMed:22137083, ECO:0000269|PubMed:22427649, ECO:0000269|PubMed:22707725}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Cardiomyopathy, familial hypertrophic, 18 (CMH18) [MIM:613874]: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. {ECO:0000269|PubMed:12705874}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Reversibly inhibits the activity of ATP2A2/SERCA2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+) (PubMed:28890335). Binds preferentially to the ATP-bound E1 conformational form of ATP2A2 which predominates at low Ca(2+) concentrations during the diastolic phase of the cardiac cycle (By similarity). Inhibits ATP2A2 Ca(2+) affinity by disrupting its allosteric activation by ATP (By similarity). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. ATP2A2 inhibition is alleviated by PLN phosphorylation (By similarity). Also inhibits the activity of ATP2A3/SERCA3 (By similarity). Controls intracellular Ca(2+) levels in elongated spermatids and may play a role in germ cell differentiation (By similarity). In the thalamic reticular nucleus of the brain, plays a role in the regulation of sleep patterns and executive functioning (By similarity). {ECO:0000250|UniProtKB:P61012, ECO:0000250|UniProtKB:P61014, ECO:0000269|PubMed:22427649, ECO:0000269|PubMed:22707725, ECO:0000269|PubMed:28890335}.
uniprot
proteins
mass_dalton
6109
uniprot
proteins
mutagenesis
MUTAGEN 13; /note="R->A: Abolishes phosphorylation by PKA."; /evidence="ECO:0000269|PubMed:22707725"; MUTAGEN 14; /note="R->A: Abolishes phosphorylation by PKA."; /evidence="ECO:0000269|PubMed:22707725"; MUTAGEN 16; /note="S->A: Abolishes phosphorylation by PKA."; /evidence="ECO:0000269|PubMed:22707725"; MUTAGEN 17; /note="T->A: No effect on phosphorylation by PKA."; /evidence="ECO:0000269|PubMed:22707725
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by PKA abolishes the inhibition of ATP2A2-mediated calcium uptake. Phosphorylated at Thr-17 by CaMK2, and in response to beta-adrenergic stimulation. Phosphorylation by DMPK may stimulate sarcoplasmic reticulum calcium uptake in cardiomyocytes. {ECO:0000269|PubMed:15598648, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:22707725}.; PTM: Palmitoylated by ZDHHC16, promoting formation of the homopentamer. {ECO:0000250|UniProtKB:P61014}.; PTM: In elongated spermatids, proteolytically cleaved by SPPL2C which modulates intracellular Ca(2+) homeostasis. {ECO:0000250|UniProtKB:P61014}.
uniprot
proteins
protein_family
Phospholamban family
uniprot
proteins
pubmed
10198197
uniprot
proteins
pubmed
12610310
uniprot
proteins
pubmed
12705874
uniprot
proteins
pubmed
12804600
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15598648
uniprot
proteins
pubmed
16043693
uniprot
proteins
pubmed
16432188
uniprot
proteins
pubmed
16690701
uniprot
proteins
pubmed
16897780
uniprot
proteins
pubmed
17241641
uniprot
proteins
pubmed
1828805
uniprot
proteins
pubmed
22137083
uniprot
proteins
pubmed
22427649
uniprot
proteins
pubmed
22707725
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28890335
uniprot
proteins
pubmed
36523160
uniprot
proteins
pubmed
7749920
uniprot
proteins
pubmed
7779806
uniprot
proteins
pubmed
9512019
uniprot
proteins
sequence_length
52
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17241641}; Single-pass membrane protein {ECO:0000255}. Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:12804600, ECO:0000269|PubMed:15598648, ECO:0000269|PubMed:22427649}; Single-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000250|UniProtKB:A4IFH6}; Single-pass membrane protein {ECO:0000255}. Membrane {ECO:0000250|UniProtKB:P61014}; Single-pass membrane protein {ECO:0000255}. Note=Colocalizes with HAX1 at the endoplasmic reticulum (PubMed:17241641). Colocalizes with DMPK at the sarcoplasmic reticulum (PubMed:15598648). {ECO:0000269|PubMed:15598648, ECO:0000269|PubMed:17241641}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..52; /note="Helical"; /evidence="ECO:0000305
uniprot
proteins