Qrich1
entrez
69232
canonical
uniprot
Q3UA37
canonical
ensembl
ENSMUSG00000006673
resolver
ensp
ENSMUSP00000006851
resolver
ensp
ENSMUSP00000107782
resolver
ensp
ENSMUSP00000141267
resolver
ensp
ENSMUSP00000229376
resolver
ensp
ENSMUSP00000229377
resolver
ensp
ENSMUSP00000229378
resolver
ensp
ENSMUSP00000229381
resolver
ensp
ENSMUSP00000229382
resolver
ensp
ENSMUSP00000229388
resolver
ensp
ENSMUSP00000229406
resolver
ensp
ENSMUSP00000229410
resolver
ensp
ENSMUSP00000229411
resolver
ensp
ENSMUSP00000229417
resolver
ensp
ENSMUSP00000336211
resolver
enst
ENSMUST00000006851
resolver
enst
ENSMUST00000112155
resolver
genesymbol
Qrich1
resolver
uniprot
G3X8R5
resolver
uniprot_entry
G3X8R5_MOUSE
resolver
uniprot_entry
QRIC1_MOUSE
resolver
amino_acid_sequence
MNNSLENTISFEEYIRVKARSVPQHRMKEFLDSLASKGPEALQEFQQTATTTMVYQQGGNCIYTDSTEVAGSLLELACPVTTSVQPQTQQEQQIQVQQPQQVQVQVQVQQSPQQVSAQQLSPQFTVHQPAEQPIQVQVQIQGQAPQSAAPSIQTPSLQSPSPSQLQAAQIQVQHVQAAQQIQAAEIPEEHIPHQQIQAQLVAGQSLAGGQQIQIQTVGALSPPPSQQGSPREGERRVGTASVLQPVKKRKVDMPITVSYAISGQPVATVLAIPQGQQQSYVSLRPDLLTVDSAHLYSATGTITSPTGETWTIPVYSAQPRGDPQQQSITHIAIPQEAYNAVHVSGSPKALAAVKLEDDKEKMVGTTSVVKNSHEEVVQTLANSLFPAQFMNGNIHIPVAVQAVAGTYQNTAQTVHIWDPQQQPQQQTAQEQTPPPQQQQQQLQVTCSAQTVQVAEVEPQSQPQPSPELLLPNSLKPEEGLEVWKNWAQTKNAELEKDAQNRLAPIGRRQLLRFQEDLISSAVAELNYGLCLMTREARNGEGEPYDPDVLYYIFLCIQKYLFENGRVDDIFSDLYYVRFTEWLHEVLKDVQPRVTPLGYVLPSHVTEEMLWECKQLGAHSPSTLLTTLMFFNTKYFLLKTVDQHMKLAFSKVLRQTKKSPSNPKDKSTSIRYLKALGIHQTGQKVTDDMYAEQTENPENPLRCPIKLYDFYLFKCPQSVKGRNDTFYLTPEPVVAPNSPIWYSVQPISREQMGQMLTRILVIREIQEAIAVANATTMH
uniprot
proteins
function
FUNCTION: Transcriptional regulator that acts as a mediator of the integrated stress response (ISR) through transcriptional control of protein homeostasis under conditions of ER stress (PubMed:33384352). Controls the outcome of the unfolded protein response (UPR) which is an ER-stress response pathway (PubMed:33384352, PubMed:39662754). ER stress induces QRICH1 translation by a ribosome translation re-initiation mechanism in response to EIF2S1/eIF-2-alpha phosphorylation, and stress-induced QRICH1 regulates a transcriptional program associated with protein translation, protein secretion-mediated proteotoxicity and cell death during the terminal UPR (PubMed:33384352). May cooperate with ATF4 transcription factor signaling to regulate ER homeostasis which is critical for cell viability (By similarity). Up-regulates CASP3/caspase-3 activity in epithelial cells under ER stress (PubMed:33384352). Central regulator of proteotoxicity associated with ER stress-mediated inflammatory diseases in the intestines and liver (By similarity). Core component of the zincore complex, a heterotetramer that acts as a molecular 'grip' to stabilize transcription factors at DNA-binding sites across the genome, thereby controlling gene expression (By similarity). The zincore complex binds specifically to zinc finger transcription factors, such as ZFP91, ZNF652, ZNF526 and PRDM15, and stabilizes them onto their cognate DNA motif (By similarity). Involved in chondrocyte hypertrophy, a process required for normal longitudinal bone growth (PubMed:30281152). {ECO:0000250|UniProtKB:Q2TAL8, ECO:0000269|PubMed:30281152, ECO:0000269|PubMed:33384352, ECO:0000269|PubMed:39662754}.
uniprot
proteins
mass_dalton
86556
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30281152
uniprot
proteins
pubmed
33384352
uniprot
proteins
pubmed
39662754
uniprot
proteins
pubmed
40608935
uniprot
proteins
sequence_length
777
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q2TAL8}. Chromosome {ECO:0000250|UniProtKB:Q2TAL8}. Cytoplasm {ECO:0000250|UniProtKB:Q2TAL8}. Cell membrane {ECO:0000250|UniProtKB:Q2TAL8}. Note=The zincore complex binds to a highly conserved promoter motif (5'-CTTTAAR-3'). {ECO:0000250|UniProtKB:Q2TAL8}.
uniprot
proteins