CCL19
entrez
6363
canonical
uniprot
Q99731
canonical
ensembl
ENSG00000172724
resolver
ensp
ENSP00000308815
resolver
enst
ENST00000311925
resolver
genesymbol
CCL19
resolver
genesymbol_syn
ELC
resolver
genesymbol_syn
MIP3B
resolver
genesymbol_syn
SCYA19
resolver
hgnc
HGNC:10617
resolver
uniprot
O00697
resolver
uniprot
O00736
resolver
uniprot
Q6IBD6
resolver
uniprot_entry
CCL19_HUMAN
resolver
uniprot_entry
Q6IBD6_HUMAN
resolver
uniprot_sec
O00697
resolver
uniprot_sec
O00736
resolver
amino_acid_sequence
MALLLALSLLVLWTSPAPTLSGTNDAEDCCLSVTQKPIPGYIVRNFHYLLIKDGCRVPAVVFTTLRGRQLCAPPDQPWVERIIQRLQRTSAKMKRRSS
uniprot
proteins
function
FUNCTION: May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Binds to atypical chemokine receptor ACKR4 and mediates the recruitment of beta-arrestin (ARRB1/2) to ACKR4. {ECO:0000269|PubMed:9498785}.
uniprot
proteins
mass_dalton
10993
uniprot
proteins
protein_family
Intercrine beta (chemokine CC) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23341447
uniprot
proteins
pubmed
27044744
uniprot
proteins
pubmed
9013939
uniprot
proteins
pubmed
9153236
uniprot
proteins
pubmed
9498785
uniprot
proteins
sequence_length
98
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins