PSMD11
entrez
5717
canonical
uniprot
O00231
canonical
ensembl
ENSG00000108671
resolver
ensp
ENSP00000261712
resolver
ensp
ENSP00000393185
resolver
genesymbol
PSMD11
resolver
hgnc
HGNC:9556
resolver
uniprot
A8K3I7
resolver
uniprot
E1P663
resolver
uniprot
O00495
resolver
uniprot
Q53FT5
resolver
uniprot_entry
PSD11_HUMAN
resolver
uniprot_sec
A8K3I7
resolver
uniprot_sec
E1P663
resolver
uniprot_sec
O00495
resolver
uniprot_sec
Q53FT5
resolver
amino_acid_sequence
MAAAAVVEFQRAQSLLSTDREASIDILHSIVKRDIQENDEEAVQVKEQSILELGSLLAKTGQAAELGGLLKYVRPFLNSISKAKAARLVRSLLDLFLDMEAATGQEVELCLECIEWAKSEKRTFLRQALEARLVSLYFDTKRYQEALHLGSQLLRELKKMDDKALLVEVQLLESKTYHALSNLPKARAALTSARTTANAIYCPPKLQATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYDSIDSPKAITSLKYMLLCKIMLNTPEDVQALVSGKLALRYAGRQTEALKCVAQASKNRSLADFEKALTDYRAELRDDPIISTHLAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKADVERKLSQMILDKKFHGILDQGEGVLIIFDEPPVDKTYEAALETIQNMSKVVDSLYNKAKKLT
uniprot
proteins
function
FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. Plays a key role in increased proteasome activity in embryonic stem cells (ESCs): its high expression in ESCs promotes enhanced assembly of the 26S proteasome, followed by higher proteasome activity. {ECO:0000269|PubMed:1317798, ECO:0000269|PubMed:22972301}.
uniprot
proteins
mass_dalton
47464
uniprot
proteins
mutagenesis
MUTAGEN 14; /note="S->A: Does not affect phosphorylation by AMPK; when associated with A-79 and A-272."; /evidence="ECO:0000269|PubMed:19616115"; MUTAGEN 79; /note="S->A: Does not affect phosphorylation by AMPK; when associated with A-14 and A-272."; /evidence="ECO:0000269|PubMed:19616115"; MUTAGEN 272; /note="S->A: Does not affect phosphorylation by AMPK; when associated with A14- and A-79."; /evidence="ECO:0000269|PubMed:19616115
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by AMPK. {ECO:0000269|PubMed:19616115}.
uniprot
proteins
protein_family
Proteasome subunit S9 family
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
1317798
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17323924
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19616115
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
22972301
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
27342858
uniprot
proteins
pubmed
27428775
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
9119060
uniprot
proteins
pubmed
9426256
uniprot
proteins
sequence_length
422
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.
uniprot
proteins