Hexb
entrez
294673
canonical
uniprot
Q6AXR4
canonical
ensembl
ENSRNOG00000025274
resolver
ensembl
ENSRNOG00055028545
resolver
ensembl
ENSRNOG00060028290
resolver
ensembl
ENSRNOG00065022045
resolver
ensp
ENSRNOP00000081104
resolver
ensp
ENSRNOP00055040704
resolver
ensp
ENSRNOP00060041090
resolver
ensp
ENSRNOP00065030400
resolver
enst
ENSRNOT00000097138
resolver
enst
ENSRNOT00055049454
resolver
enst
ENSRNOT00060049231
resolver
enst
ENSRNOT00065037610
resolver
genesymbol
Hexb
resolver
uniprot_entry
HEXB_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Addition of GM2A stimulates the hydrolysis of sulfated glycosphingolipid SM2 and the ganglioside GM2. {ECO:0000250|UniProtKB:P07686}.
uniprot
proteins
amino_acid_sequence
MPGSPRRAPGLLLQALVAMVSLALVAPFGLQPALWPMPRSVQVFPRLLYISPENFQIDNSPNSTAGPSCSLLLEAFRRYYNYIFGFYKRHHGPAKFQDKPQLEKLLVFINLEPQCDAFPSMSSDESYSLLVQEPVALLKANEVWGALRGLETFSQLVYQDAYGTFTINESTIADSPRFPHRGILIDTSRHYLPVKTIFKTLDAMAFNKFNVLHWHIVDDQSFPYQSITFPELSNKGSYSLSHVYTPNDIHMVLEYARLRGIRVIPEFDSPGHTQSWGKGQKNLLTPCFIQKIRTQKVGPVDPSLNTTYVFFDTFFKEISRVFPDQFIHLGGDEVEFECWASNPNIQNFMKKKGFGNNFRRLESFYIKKILDIITSLKKSSIVWQDVFDDQVELQPGTVVEVWKSENYLNELAQVTASGFPAILSAPWYLDLISYGQDWRNYYKAEPLNFEGSEKQKQLVIGGEACLWGEYVDATNLIPRLWPRASAVGERLWSPRIITNLENAYRRLAVHRCRMVSRGIAAQPLFTGYCNYENKMEK
uniprot
proteins
ec_number
3.2.1.52
uniprot
proteins
function
FUNCTION: Hydrolyzes the non-reducing end N-acetyl-D-hexosamine and/or sulfated N-acetyl-D-hexosamine of glycoconjugates, such as the oligosaccharide moieties from proteins and neutral glycolipids, or from certain mucopolysaccharides. The isozyme B does not hydrolyze each of these substrates, however hydrolyzes efficiently neutral oligosaccharide. Only the isozyme A is responsible for the degradation of GM2 gangliosides in the presence of GM2A (By similarity). During fertilization is responsible, at least in part, for the zona block to polyspermy. Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and inactivates the sperm galactosyltransferase-binding site, accounting for the block in sperm binding to the zona pellucida (By similarity). {ECO:0000250|UniProtKB:P07686, ECO:0000250|UniProtKB:P20060}.
uniprot
proteins
mass_dalton
61527
uniprot
proteins
protein_family
Glycosyl hydrolase 20 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
537
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:P07686}. Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000250|UniProtKB:P20060}.
uniprot
proteins