SPCS3
entrez
60559
canonical
uniprot
P61009
canonical
ensembl
ENSG00000129128
resolver
ensp
ENSP00000427463
resolver
enst
ENST00000503362
resolver
genesymbol
SPCS3
resolver
genesymbol_syn
SPC22
resolver
hgnc
HGNC:26212
resolver
uniprot
P12280
resolver
uniprot
Q9H0S7
resolver
uniprot_entry
SPCS3_HUMAN
resolver
uniprot_sec
P12280
resolver
uniprot_sec
Q9H0S7
resolver
amino_acid_sequence
MNTVLSRANSLFAFSLSVMAALTFGCFITTAFKDRSVPVRLHVSRIMLKNVEDFTGPRERSDLGFITFDITADLENIFDWNVKQLFLYLSAEYSTKNNALNQVVLWDKIVLRGDNPKLLLKDMKTKYFFFDDGNGLKGNRNVTLTLSWNVVPNAGILPLVTGSGHVSVPFPDTYEITKSY
uniprot
proteins
function
FUNCTION: Essential component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:27499293, PubMed:34388369). Essential for the SPC catalytic activity, possibly by stabilizing and positioning the active center of the complex close to the lumenal surface (By similarity). {ECO:0000250|UniProtKB:Q12133, ECO:0000269|PubMed:27499293, ECO:0000269|PubMed:34388369}.; FUNCTION: (Microbial infection) Plays an important role in virion production of flaviviruses such as West Nile virus, Japanese enchephalitis virus, Dengue virus type 2 and Yellow Fever virus. {ECO:0000269|PubMed:27383988}.
uniprot
proteins
mass_dalton
20313
uniprot
proteins
protein_family
SPCS3 family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27383988
uniprot
proteins
pubmed
27499293
uniprot
proteins
pubmed
34388369
uniprot
proteins
sequence_length
180
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P61008}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P61008}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins