LRRC25
entrez
126364
canonical
uniprot
Q8N386
canonical
ensembl
ENSG00000175489
resolver
ensp
ENSP00000340983
resolver
ensp
ENSP00000472290
resolver
enst
ENST00000339007
resolver
enst
ENST00000595840
resolver
genesymbol
LRRC25
resolver
genesymbol_syn
MAPA
resolver
hgnc
HGNC:29806
resolver
uniprot
Q6IQ00
resolver
uniprot
Q8N9A5
resolver
uniprot_entry
LRC25_HUMAN
resolver
uniprot_sec
Q6IQ00
resolver
uniprot_sec
Q8N9A5
resolver
amino_acid_sequence
MGGTLAWTLLLPLLLRESDSLEPSCTVSSADVDWNAEFSATCLNFSGLSLSLPHNQSLRASNVILLDLSGNGLRELPVTFFAHLQKLEVLNVLRNPLSRVDGALAARCDLDLQADCNCALESWHDIRRDNCSGQKPLLCWDTTSSQHNLSAFLEVSCAPGLASATIGAVVVSGCLLLGLAIAGPVLAWRLWRCRVARSRELNKPWAAQDGPKPGLGLQPRYGSRSAPKPQVAVPSCPSTPDYENMFVGQPAAEHQWDEQGAHPSEDNDFYINYKDIDLASQPVYCNLQSLGQAPMDEEEYVIPGH
uniprot
proteins
function
FUNCTION: Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting RIGI for autophagic degradation. Interacts specifically with ISG15-associated RIGI to promote interaction between RIGI and the autophagic cargo receptor p62/SQSTM1 to mediate RIGI degradation via selective autophagy (PubMed:29288164). Also plays a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA. {ECO:0000269|PubMed:12384430, ECO:0000269|PubMed:29044191, ECO:0000269|PubMed:29288164}.
uniprot
proteins
mass_dalton
33179
uniprot
proteins
pubmed
12384430
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
29044191
uniprot
proteins
pubmed
29288164
uniprot
proteins
sequence_length
305
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:29044191}.
uniprot
proteins
transmembrane_region
TRANSMEM 166..186; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins