Hsd11b1
entrez
15483
canonical
uniprot
P50172
canonical
ensembl
ENSMUSG00000016194
resolver
ensp
ENSMUSP00000016338
resolver
ensp
ENSMUSP00000123849
resolver
ensp
ENSMUSP00000125620
resolver
ensp
ENSMUSP00000212318
resolver
ensp
ENSMUSP00000212320
resolver
ensp
ENSMUSP00000212327
resolver
enst
ENSMUST00000016338
resolver
enst
ENSMUST00000160929
resolver
enst
ENSMUST00000161737
resolver
genesymbol
Hsd11b1
resolver
genesymbol_syn
Hsd11
resolver
uniprot
F6UTH4
resolver
uniprot
Q3TJI8
resolver
uniprot
Q4JHD9
resolver
uniprot_entry
DHI1_MOUSE
resolver
uniprot_entry
F6UTH4_MOUSE
resolver
uniprot_entry
Q3TJI8_MOUSE
resolver
uniprot_entry
Q4JHD9_MOUSE
resolver
amino_acid_sequence
MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMIAPYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEECALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN
uniprot
proteins
ec_number
1.1.1.146
uniprot
proteins
ec_number
1.1.1.201
uniprot
proteins
function
FUNCTION: Controls the reversible conversion of biologically active glucocorticoids such as 11-dehydrocorticosterone to corticosterone in the presence of NADP(H) (PubMed:23415904, PubMed:30902677, PubMed:9405715). Participates in the corticosteroid receptor-mediated anti-inflammatory response, as well as metabolic and homeostatic processes (PubMed:9405715). Bidirectional in vitro, predominantly functions as a reductase in vivo, thereby increasing the concentration of active glucocorticoids (PubMed:23415904). It has broad substrate specificity, besides glucocorticoids, it accepts other steroid and sterol substrates (PubMed:23415904). Interconverts 7-oxo- and 7-hydroxy-neurosteroids such as 7-oxopregnenolone and 7beta-hydroxypregnenolone, 7-oxodehydroepiandrosterone (3beta-hydroxy-5-androstene-7,17-dione) and 7beta-hydroxydehydroepiandrosterone (3beta,7beta-dihydroxyandrost-5-en-17-one), among others (By similarity). Catalyzes the stereo-specific conversion of the major dietary oxysterol, 7-ketocholesterol (7-oxocholesterol), into the more polar 7-beta-hydroxycholesterol metabolite (PubMed:23415904). 7-oxocholesterol is one of the most important oxysterols, it participates in several events such as induction of apoptosis, accumulation in atherosclerotic lesions, lipid peroxidation, and induction of foam cell formation (By similarity). Mediates the 7-oxo reduction of 7-oxolithocholate mainly to chenodeoxycholate, and to a lesser extent to ursodeoxycholate, both in its free form and when conjugated to glycine or taurine, providing a link between glucocorticoid activation and bile acid metabolism (By similarity). Catalyzes the synthesis of 7-beta-25-dihydroxycholesterol from 7-oxo-25-hydroxycholesterol in vitro, which acts as a ligand for the G protein-coupled receptor (GPCR) Epstein-Barr virus-induced gene 2 (EBI2) and may thereby regulate immune cell migration (PubMed:30902677). {ECO:0000250|UniProtKB:P28845, ECO:0000269|PubMed:23415904, ECO:0000269|PubMed:30902677, ECO:0000269|PubMed:9405715, ECO:0000303|PubMed:23415904, ECO:0000303|PubMed:9405715}.
uniprot
proteins
mass_dalton
32364
uniprot
proteins
pathway_participation
PATHWAY: Steroid metabolism. {ECO:0000305}.
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
15865440
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23415904
uniprot
proteins
pubmed
30902677
uniprot
proteins
pubmed
7851387
uniprot
proteins
pubmed
7873449
uniprot
proteins
pubmed
8973338
uniprot
proteins
pubmed
9405715
uniprot
proteins
sequence_length
292
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type II membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 8..24; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins