Mc1r
entrez
17199
canonical
uniprot
Q01727
canonical
ensembl
ENSMUSG00000074037
resolver
ensp
ENSMUSP00000095929
resolver
enst
ENSMUST00000098324
resolver
genesymbol
Mc1r
resolver
genesymbol_syn
Msh-r
resolver
uniprot
Q75NA3
resolver
uniprot_entry
MSHR_MOUSE
resolver
uniprot_sec
Q75NA3
resolver
amino_acid_sequence
MSTQEPQKSLLGSLNSNATSHLGLATNQSEPWCLYVSIPDGLFLSLGLVSLVENVLVVIAITKNRNLHSPMYYFICCLALSDLMVSVSIVLETTIILLLEAGILVARVALVQQLDNLIDVLICGSMVSSLCFLGIIAIDRYISIFYALRYHSIVTLPRARRAVVGIWMVSIVSSTLFITYYKHTAVLLCLVTFFLAMLALMAILYAHMFTRACQHAQGIAQLHKRRRSIRQGFCLKGAATLTILLGIFFLCWGPFFLHLLLIVLCPQHPTCSCIFKNFNLFLLLIVLSSTVDPLIYAFRSQELRMTLKEVLLCSW
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that binds melanocyte-stimulating hormones (alpha, beta, and gamma-MSH) and adrenocorticotropic hormone/ACTH, which are peptide products of the POMC precursor protein (PubMed:1325670). Upon activation, MC1R couples with the G(s) protein, stimulating adenylate cyclase and activating the cAMP-dependent signaling pathway. This activation promotes melanogenesis, resulting in the production of eumelanin (black/brown) and pheomelanin (red/yellow) in melanocytes. MC1R interacts with G protein-coupled receptor opsin 3/OPN3, which couples to G(i) proteins and inhibits the alpha-MSH-induced cAMP response, thereby reducing melanin synthesis (By similarity). Binding to Agouti/ASP precludes alpha-MSH-induced signaling, thereby down-regulating melanogenesis (PubMed:7935841). Additionally, interaction with MGRN1 displaces the G(s) protein, further suppressing MC1R signaling (By similarity). {ECO:0000250|UniProtKB:Q01726, ECO:0000269|PubMed:1325670, ECO:0000269|PubMed:7935841}.
uniprot
proteins
mass_dalton
35226
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
1325670
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15653560
uniprot
proteins
pubmed
7935841
uniprot
proteins
sequence_length
315
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q01726}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..59; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q01726"; TRANSMEM 74..98; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q01726"; TRANSMEM 112..138; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q01726"; TRANSMEM 161..181; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q01726"; TRANSMEM 185..207; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q01726"; TRANSMEM 237..261; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q01726"; TRANSMEM 277..299; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q01726
uniprot
proteins