Lgr4
entrez
107515
canonical
uniprot
A2ARI4
canonical
ensembl
ENSMUSG00000050199
resolver
ensp
ENSMUSP00000047325
resolver
ensp
ENSMUSP00000316970
resolver
genesymbol
Lgr4
resolver
genesymbol_syn
Gpr48
resolver
uniprot
A2ARI3
resolver
uniprot
Q6PHA3
resolver
uniprot
Q80T31
resolver
uniprot
Q8BXS9
resolver
uniprot
Q8BZR7
resolver
uniprot_entry
LGR4_MOUSE
resolver
uniprot_entry
Q8BZR7_MOUSE
resolver
uniprot_sec
A2ARI3
resolver
uniprot_sec
Q6PHA3
resolver
uniprot_sec
Q80T31
resolver
uniprot_sec
Q8BXS9
resolver
amino_acid_sequence
MPGPLRLLCFFALGLLGSAGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNILTEVPVRPLSNLPTLQALTLALNNISSIPDFAFTNLSSLVVLHLHNNKIKSLSQHCFDGLDNLETLDLNYNNLDEFPQAIKALPSLKELGFHSNSISVIPDGAFAGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASLVQWFPNLAGTVHLESLTLTGTKISSIPDDLCQNQKMLRTLDLSYNDIRDLPSFNGCRALEEISLQRNQISLIKETTFQGLTSLRILDLSRNLIREIHSGAFAKLGTITNLDVSFNELTSFPTEGLNGLNQLKLVGNFQLKDALAARDFANLRSLSVPYAYQCCAFWGCDSYANLNTEDNSPQDHSVTKEKGATDAANATSTAESEEHSQIIIHCTPSTGAFKPCEYLLGSWMIRLTVWFIFLVALLFNLLVILTVFASCSSLPASKLFIGLISVSNLLMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCKVAGSLAVFSSESAVFLLTLAAVERSVFAKDVMKNGKSSHLRQFQVAALVALLGAAIAGCFPLFHGGQYSASPLCLPFPTGETPSLGFTVTLVLLNSLAFLLMAIIYTKLYCNLEKEDPSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAISISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKDDWKLLKRRVTRKHGSVSVSISSQGGCGEQDFYYDCGMYSHLQGNLTVCDCCESFLLTKPVSCKHLIKSHSCPVLTVASCQRPEAYWSDCGTQSAHSDYADEEDSFVSDSSDQVQACGRACFYQSRGFPLVRYAYNLPRVRD
uniprot
proteins
function
FUNCTION: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and is involved in the formation of various organs. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G protein-coupled receptors, does not activate heterotrimeric G proteins to transduce the signal. Its function as activator of the Wnt signaling pathway is required for the development of various organs, including liver, kidney, intestine, bone, reproductive tract and eye. May also act as a receptor for norrin (NDP), such results however require additional confirmation in vivo. Required during spermatogenesis to activate the Wnt signaling pathway in peritubular myoid cells. Required for the maintenance of intestinal stem cells and Paneth cell differentiation in postnatal intestinal crypts. Acts as a regulator of bone formation and remodeling. Involved in kidney development; required for maintaining the ureteric bud in an undifferentiated state. Involved in the development of the anterior segment of the eye. Required during erythropoiesis. Also acts as a negative regulator of innate immunity by inhibiting TLR2/TLR4 associated pattern-recognition and pro-inflammatory cytokine production. Plays an important role in regulating the circadian rhythms of plasma lipids, partially through regulating the rhythmic expression of MTTP (PubMed:24353284). Required for proper development of GnRH neurons (gonadotropin-releasing hormone expressing neurons) that control the release of reproductive hormones from the pituitary gland (PubMed:32493844). {ECO:0000269|PubMed:18955481, ECO:0000269|PubMed:19605502, ECO:0000269|PubMed:21508962, ECO:0000269|PubMed:21693646, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:23393138, ECO:0000269|PubMed:23444378, ECO:0000269|PubMed:23533175, ECO:0000269|PubMed:23589304, ECO:0000269|PubMed:24353284, ECO:0000269|PubMed:32493844}.
uniprot
proteins
mass_dalton
104150
uniprot
proteins
mutagenesis
MUTAGEN 755; /note="T->I: Confers constitutive activity."; /evidence="ECO:0000269|PubMed:23589304
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12679517
uniprot
proteins
pubmed
15192078
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16406039
uniprot
proteins
pubmed
16785743
uniprot
proteins
pubmed
17079737
uniprot
proteins
pubmed
17850793
uniprot
proteins
pubmed
18424556
uniprot
proteins
pubmed
18651655
uniprot
proteins
pubmed
18955481
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19605502
uniprot
proteins
pubmed
20638054
uniprot
proteins
pubmed
21508962
uniprot
proteins
pubmed
21523854
uniprot
proteins
pubmed
21693646
uniprot
proteins
pubmed
21727895
uniprot
proteins
pubmed
23393138
uniprot
proteins
pubmed
23444378
uniprot
proteins
pubmed
23533175
uniprot
proteins
pubmed
23589304
uniprot
proteins
pubmed
24353284
uniprot
proteins
pubmed
29769720
uniprot
proteins
pubmed
32493844
uniprot
proteins
sequence_length
951
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21693646}; Multi-pass membrane protein {ECO:0000269|PubMed:21693646}.
uniprot
proteins
transmembrane_region
TRANSMEM 545..565; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 576..596; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 620..640; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 662..682; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 704..724; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 757..777; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 784..804; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins