Plscr4
entrez
235527
canonical
uniprot
P58196
canonical
ensembl
ENSMUSG00000032377
resolver
ensp
ENSMUSP00000034941
resolver
ensp
ENSMUSP00000277298
resolver
enst
ENSMUST00000034941
resolver
genesymbol
Plscr4
resolver
uniprot
Q3TMI2
resolver
uniprot
Q8BH62
resolver
uniprot
Q8BV91
resolver
uniprot_entry
PLS4_MOUSE
resolver
uniprot_entry
Q8BV91_MOUSE
resolver
uniprot_sec
Q3TMI2
resolver
uniprot_sec
Q8BH62
resolver
amino_acid_sequence
MSGLVPTAPEQPTEEMENQIKSPTAVPDAPPDYNSHFAPGPAGPVASPSAGLPMGYYIPQQPGAIPLYHPTGGTHPIQYQPGKYPVTNQPAPIMWMAGPAPVPNCPPGLEYLAQLDNIHVLQHVEPLELMTRFETNNRYDIKNNIDQMVYIVTEDTDDFTRNAYRNLRPFVLRVTDCLGREIMTMQRPFRCTCCCFCCPCARQELEVQCPPGVTIGFVAEHWNLCRASYSIQNEKKESMMRVRGPCATYGCGSDSVFEINSLDGVSNIGSIIRKWNGFLSTMVNADHFEIRFPLALDVKMKAMIFGSCFLIDFMYFERPPPRRMSR
uniprot
proteins
function
FUNCTION: Catalyzes metal ion-induced ATP-independent rapid bidirectional and non-specific movement of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane and participates in the redistribution of phospholipids between membrane leaflets. Metal ions bind to the calcium-binding site and induce conformation change in the protein. Has a greater affi nity for Ca(2+) than Mg(2+) and Zn(2+). {ECO:0000250|UniProtKB:Q9NRQ2}.
uniprot
proteins
mass_dalton
36579
uniprot
proteins
protein_family
Phospholipid scramblase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
326
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9NRQ2}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O15162}. Cell membrane {ECO:0000250|UniProtKB:Q9NRQ2}; Lipid-anchor {ECO:0000250|UniProtKB:Q9NRQ2}; Cytoplasmic side {ECO:0000250|UniProtKB:O15162}. Nucleus {ECO:0000250|UniProtKB:Q9NRQ2}. Note=Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus. {ECO:0000250|UniProtKB:Q9NRQ2}.
uniprot
proteins
transmembrane_region
TRANSMEM 300..316; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O15162
uniprot
proteins