Rpsa
entrez
29236
canonical
uniprot
P38983
canonical
ensembl
ENSRNOG00000018645
resolver
ensp
ENSRNOP00000025224
resolver
enst
ENSRNOT00000025225
resolver
genesymbol
Rpsa
resolver
genesymbol_syn
Lamr1
resolver
uniprot
A0A8L2UK17
resolver
uniprot
B6ZB78
resolver
uniprot_entry
A0A8L2UK17_RAT
resolver
uniprot_entry
RSSA_RAT
resolver
uniprot_sec
B6ZB78
resolver
amino_acid_sequence
MSGGLDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIINLKRTWEKLLLAARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGRFTPGTFTNQIQAAFREPRLLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIAIPCNNKGAHSVGLMWWMLAREVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPEFTAAQPEVADWSEGVQVPSVPIQQFPTEDWSAQPATEDWSAAPTAQATEWVGATTEWS
uniprot
proteins
function
FUNCTION: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA. {ECO:0000255|HAMAP-Rule:MF_03016, ECO:0000269|PubMed:16453457}.
uniprot
proteins
mass_dalton
32824
uniprot
proteins
post_translational_modification
PTM: Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association. {ECO:0000255|HAMAP-Rule:MF_03016}.; PTM: Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions. {ECO:0000255|HAMAP-Rule:MF_03016}.
uniprot
proteins
protein_family
Universal ribosomal protein uS2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15548204
uniprot
proteins
pubmed
16453457
uniprot
proteins
pubmed
8076763
uniprot
proteins
pubmed
8119397
uniprot
proteins
pubmed
8910435
uniprot
proteins
pubmed
925037
uniprot
proteins
sequence_length
295
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_03016, ECO:0000269|PubMed:15548204}. Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03016, ECO:0000269|PubMed:15548204}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03016}. Note=67LR is found at the surface of the plasma membrane, with its C-terminal laminin-binding domain accessible to extracellular ligands. 37LRP is found at the cell surface, in the cytoplasm and in the nucleus. Colocalizes with PPP1R16B in the cell membrane (By similarity). {ECO:0000255|HAMAP-Rule:MF_03016}.
uniprot
proteins