Thoc6
entrez
386612
canonical
uniprot
Q5U4D9
canonical
ensembl
ENSMUSG00000041319
resolver
ensp
ENSMUSP00000038137
resolver
ensp
ENSMUSP00000093239
resolver
ensp
ENSMUSP00000111153
resolver
enst
ENSMUST00000047436
resolver
enst
ENSMUST00000095579
resolver
enst
ENSMUST00000115490
resolver
genesymbol
Thoc6
resolver
genesymbol_syn
Wdr58
resolver
uniprot_entry
THOC6_MOUSE
resolver
amino_acid_sequence
MEHAAPLAVPLGQAEVFQALQRLHMTIFSQSVSPCGKFLAAGNNYGQIAIFSLSAALSSEAKEESKKPVVVFHAHDGPVYSMVSTDRHLLSAGDGEVKGWLWAEILKKGCKELWRRQPPYRTSLEVPEINALLLVPKENSLILAGGDCQLHSMDLETGAFTRALRGHTDYIHCLALRERSPEVLSGGEDGAVRLWDLRIAKEVQTIEVYKHEECSRPHNGRWIGCLATDSDWMVCGGGPALTLWHLRSSTPTTVFPIRAPQKHVTFYQDLILSAGQGCCVNHWQLSGELKAQVPGSSPGLLSLSLNQQPAAPECKVLTASGNSCRVDVFTNLGYRAFSLSF
uniprot
proteins
function
FUNCTION: Component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. Plays a key structural role in the oligomerization of the THO-DDX39B complex. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NXF1 pathway. Plays a role in apoptosis negative control involved in brain development. {ECO:0000250|UniProtKB:Q86W42}.
uniprot
proteins
mass_dalton
37315
uniprot
proteins
protein_family
WD repeat THOC6 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
341
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}.
uniprot
proteins