Sgta
entrez
64667
canonical
uniprot
O70593
canonical
ensembl
ENSRNOG00000019891
resolver
ensp
ENSRNOP00000026960
resolver
ensp
ENSRNOP00000081994
resolver
ensp
ENSRNOP00000086443
resolver
enst
ENSRNOT00000026960
resolver
enst
ENSRNOT00000115492
resolver
genesymbol
Sgta
resolver
genesymbol_syn
Sgt
resolver
genesymbol_syn
Sgt1
resolver
genesymbol_syn
Stg
resolver
uniprot
A0A8I6A276
resolver
uniprot
A0A8L2QED2
resolver
uniprot
Q548F5
resolver
uniprot_entry
A0A8I6A276_RAT
resolver
uniprot_entry
A0A8L2QED2_RAT
resolver
uniprot_entry
SGTA_RAT
resolver
uniprot_sec
Q548F5
resolver
amino_acid_sequence
MDNRKRLAYAIIQFLHGQLRHGGLSSDAQESLEVAIQCLETAFGVTLEDSDLALPQTLPEIFEAATASKEMPQDPRGPDRTPPSEEDSAEAERLKTEGNEQMKLENFEAAVHLYGKAIELNPANAVYFCNRAAAYSKLGNYVGAVQDCERAIGIDPGYSKAYGRMGLALSSLNKHAEAVAYYKKALELDPDNDTYKSNLKIAELKLREAPSPTGGVGSLDIAGLLNNPHFITMASSLMNSPQLQQLMSGMISGGHNPLGTPGSSPQHSDLASLIQAGQQFAQQMQQQNPEFVEQIRSQVVRSRTPSASHEEQQE
uniprot
proteins
function
FUNCTION: Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails. Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module. Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins. It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states. Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex (By similarity). Binds directly to HSC70 and HSP70 and regulates their ATPase activity (PubMed:12878599). {ECO:0000250|UniProtKB:O43765, ECO:0000269|PubMed:12878599}.
uniprot
proteins
mass_dalton
34157
uniprot
proteins
protein_family
SGT family
uniprot
proteins
pubmed
12878599
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15708368
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9557704
uniprot
proteins
sequence_length
314
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O43765}. Nucleus {ECO:0000250|UniProtKB:O43765}. Note=Co-localizes with HSP90AB1 in the cytoplasm. Increased nuclear accumulation seen during cell apoptosis. {ECO:0000250|UniProtKB:O43765}.
uniprot
proteins