Cd68
entrez
12514
canonical
uniprot
P31996
canonical
ensembl
ENSMUSG00000018774
resolver
ensp
ENSMUSP00000018918
resolver
genesymbol
Cd68
resolver
uniprot
O54688
resolver
uniprot
O70321
resolver
uniprot
Q3S4A9
resolver
uniprot
Q5F2A8
resolver
uniprot
Q9DD15
resolver
uniprot_entry
CD68_MOUSE
resolver
uniprot_sec
O54688
resolver
uniprot_sec
O70321
resolver
uniprot_sec
Q3S4A9
resolver
uniprot_sec
Q5F2A8
resolver
uniprot_sec
Q9DD15
resolver
amino_acid_sequence
MRLPVCLILLGPLIAQGTEEDCPHKKAVTLLPSFTMTPTATESTASPTTSHRPTTTSHGNVTVHTSSGPTTVTHNPATTTSHGNATISHATVSPTTNGTATSPRSSTVGPHPGPPPPSPSPRSKGALGNYTWANGSQPCVQLQAQIQIRILYPIQGGRKAWGISVLNPNKTKVQGGCDGTHPHLSLSFPYGQLTFGFKQDLHQSPSTVYLDYMAVEYNVSFPQAAQWTFMAQNSSLRELQAPLGQSFCCGNASIVLSPAVHLDLLSLRLQAAQLPDKGHFGPCFSCNRDQSLLLPLIIGLVLLGLLTLVLIAFCITRRRQSTYQPL
uniprot
proteins
function
FUNCTION: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.
uniprot
proteins
mass_dalton
34818
uniprot
proteins
post_translational_modification
PTM: N- and O-glycosylated.
uniprot
proteins
protein_family
LAMP family
uniprot
proteins
pubmed
10524236
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16521125
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8486654
uniprot
proteins
pubmed
9479000
uniprot
proteins
pubmed
9653646
uniprot
proteins
pubmed
9806844
uniprot
proteins
sequence_length
326
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform Long]: Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform Short]: Cell membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 292..316; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00740
uniprot
proteins