MEMO1
entrez
51072
canonical
uniprot
Q9Y316
canonical
ensembl
ENSG00000162959
resolver
ensp
ENSP00000295065
resolver
ensp
ENSP00000385557
resolver
ensp
ENSP00000400795
resolver
ensp
ENSP00000578908
resolver
ensp
ENSP00000578909
resolver
ensp
ENSP00000578911
resolver
ensp
ENSP00000621289
resolver
genesymbol
MEMO1
resolver
genesymbol_syn
C2orf4
resolver
genesymbol_syn
MEMO
resolver
genesymbol_syn
NS5ATP7
resolver
hgnc
HGNC:14014
resolver
uniprot
A8K3Y8
resolver
uniprot
B4DLS0
resolver
uniprot
D6W575
resolver
uniprot
Q5R2V8
resolver
uniprot
Q5R2V9
resolver
uniprot
Q6NSL5
resolver
uniprot_entry
A8K3Y8_HUMAN
resolver
uniprot_entry
MEMO1_HUMAN
resolver
uniprot_sec
B4DLS0
resolver
uniprot_sec
D6W575
resolver
uniprot_sec
Q5R2V8
resolver
uniprot_sec
Q5R2V9
resolver
uniprot_sec
Q6NSL5
resolver
amino_acid_sequence
MSNRVVCREASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNTICGRHPIGVLLNAITELQKNGMNMSFSFLNYAQSSQCRNWQDSSVSYAAGALTVH
uniprot
proteins
function
FUNCTION: May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration. {ECO:0000269|PubMed:15156151, ECO:0000269|PubMed:20937854}.
uniprot
proteins
mass_dalton
33733
uniprot
proteins
mutagenesis
MUTAGEN 16; /note="W->A: Abolishes interaction with ERBB2."; /evidence="ECO:0000269|PubMed:18045866"; MUTAGEN 49; /note="H->A: Abolishes interaction with ERBB2."; /evidence="ECO:0000269|PubMed:18045866"; MUTAGEN 54; /note="Y->A: Diminishes interaction with ERBB2."; /evidence="ECO:0000269|PubMed:18045866"; MUTAGEN 81; /note="H->A: Abolishes interaction with ERBB2."; /evidence="ECO:0000269|PubMed:18045866"; MUTAGEN 192; /note="H->A: Abolishes interaction with ERBB2."; /evidence="ECO:0000269|PubMed:18045866"; MUTAGEN 244; /note="C->A: Abolishes interaction with ERBB2."; /evidence="ECO:0000269|PubMed:18045866
uniprot
proteins
protein_family
MEMO1 family
uniprot
proteins
pubmed
10810093
uniprot
proteins
pubmed
11707072
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15156151
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18045866
uniprot
proteins
pubmed
20937854
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
297
uniprot
proteins