Kw 1114
cv_term_accession
KW-1114
canonical
uniprot_keyword
KW-1114
canonical
name
Inhibition of host interferon signaling pathway by virus
uniprot
definition
Viral protein involved in the evasion of host innate defense by inhibiting the interferon signaling pathway leading to the production of interferon-induced genes. Interferons bind to the IFN receptors (IFNAR) on the cell surface and activate Jak/Tyk kinases. These kinases phosphorylate STAT1 and STAT2 that translocate to the nucleus and induce the expression of interferon stimulated genes (ISGs). Many viruses interact with components of this pathway to prevent expression of ISGs and inhibit the host immune response.
uniprot
keywords
is_obsolete
false
uniprot
keywords
ontology_id
uniprot_keywords
uniprot
keywords