Hormad1
entrez
365868
canonical
uniprot
D3ZWE7
canonical
ensembl
ENSRNOG00000021160
resolver
ensembl
ENSRNOG00055031559
resolver
ensembl
ENSRNOG00060013194
resolver
ensembl
ENSRNOG00065023323
resolver
ensp
ENSRNOP00000063863
resolver
ensp
ENSRNOP00000105827
resolver
ensp
ENSRNOP00055045194
resolver
ensp
ENSRNOP00060017825
resolver
ensp
ENSRNOP00065032441
resolver
enst
ENSRNOT00000066821
resolver
enst
ENSRNOT00055054676
resolver
enst
ENSRNOT00060022491
resolver
enst
ENSRNOT00065039897
resolver
genesymbol
Hormad1
resolver
uniprot
D3ZZR2
resolver
uniprot_entry
HORM1_RAT
resolver
uniprot_sec
D3ZZR2
resolver
amino_acid_sequence
MATMQLRRTASMSALVFPNKISTEQQSLMFVKRLLAVSVSCITYLRGIFPERAYGTRYLDDLCVKILKEDKNCPGSSQLVKWMLGCYDALQKKYLRMIILAVYTNPEDPQTISECYQFKFKYTKNGPIMDFISKNQNNKSSTTSADTKKASILLIRKIYVLMQNLGPLPNDVCLTMKLFYYDEVTPPDYQPPGFKDGDCEGVIFDGDPTYLNVGEVPTPFHTFRLKVTTEKERMENIDSAILTPKDSKIPFQKILMDKDDVEDENHNNFDIKTKMNEQNENSGTSEIKEPNLDCKEEEIMQFKKNQSSSISQCQVEQLISKTSELDVSESKTRSGKIFQCKMVNGNQQGQISKENRKRSLRQSGKTVLHILESSSQESVLKRRRVSEPNEHT
uniprot
proteins
function
FUNCTION: Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. {ECO:0000250|UniProtKB:Q9D5T7}.
uniprot
proteins
mass_dalton
44885
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-375 in a SPO11-dependent manner. {ECO:0000250|UniProtKB:Q9D5T7}.
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
392
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9D5T7}. Chromosome {ECO:0000250|UniProtKB:Q9D5T7}. Note=Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes. The expression of the phosphorylated form at Ser-375 is restricted to unsynapsed chromosomal regions (By similarity). {ECO:0000250|UniProtKB:Q9D5T7}.
uniprot
proteins