Gucy2c
entrez
25711
canonical
uniprot
P23897
canonical
ensembl
ENSRNOG00000009031
resolver
ensembl
ENSRNOG00055025690
resolver
ensp
ENSRNOP00000012212
resolver
ensp
ENSRNOP00055036262
resolver
enst
ENSRNOT00000012212
resolver
enst
ENSRNOT00055044321
resolver
genesymbol
Gucy2c
resolver
genesymbol_syn
Guc2c
resolver
uniprot_entry
GUC2C_RAT
resolver
amino_acid_sequence
MTSLLGLAVRLLLFQPTLMFWASQVRQKCHNGTYEISVLMMDNSAYKEPLQNLRDAVEEGLDIVRKRLREAELNVTVNATFIYSDGLIHKSGDCRSSTCEGLDLLREITRDRKMGCVLMGPSCTYSTFQMYLDTELNYPMISAGSFGLSCDYKETLTRILPPARKLMYFLVDFWKVNNAPFKTFSWNSSYVYKNGSEPEDCFWYLNALEAGVSYFSEVLSFKDVLRRSEQFQEILMGRNRKSNVIVMCGTPETFYNVKGDLKVADDTVVILVDLFSNHYFEDDTRAPEYMDNVLVLTLPPEKFIANASVSGRFPSERSDFSLAYLEGTLLFGHMLQTFLENGESVTTPKFARAFRNLTFQGLEGPVTLDDSGDIDNIMCLLYVSLDTRKYKVLMAYDTHKNQTIPVATSPNFIWKNHRLPNDVPGLGPQILMIAVFTLTGIVVVLLLIALLVLRKYRRDHELRQKKWSHIPSENIFPLETNETNHVSLKIDDDRRRDTIQRVRQCKYDKKKVILKDLKHCDGNFSEKQKIELNKLLQSDYYNLTKFYGTVKLDTRIFGVVEYCERGSLREVLNDTISYPDGTFMDWEFKISVLNDIAKGMSYLHSSKIEVHGRLKSTNCVVDSRMVVKITDFGCNSILPPKKDLWTAPEHLRQATISQKGDVYSFSIIAQEIILRKETFYTLSCRDQNEKIFRVENSYGTKPFRPDLFLETADEKELEVYLLVKSCWEEDPEKRPDFKKIESTLAKIFGLFHDQKNESYMDTLIRRLQLYSRNLEHLVEERTQLYKAERDRADHLNFMLLPRLVVKSLKEKGIVEPELYEEVTIYFSDIVGFTTICKYSTPMEVVDMLNDIYKSFDQIVDHHDVYKVETIGDAYVVASGLPMRNGNRHAVDISKMALDILSFMGTFELEHLPGLPVWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHMSSSTIAILRRTDCQFLYEVRGETYLKGRGTETTYWLTGMKDQEYNLPTPPTVENQQRLQTEFSDMIVSALQKRQASGVKSRRPTRVASYKKGFLEYMQLNNSDHDSTYF
uniprot
proteins
ec_number
4.6.1.2
uniprot
proteins
function
FUNCTION: Guanylyl cyclase that catalyzes synthesis of cyclic GMP (cGMP) from GTP (PubMed:1701694). Receptor for the E.coli heat-stable enterotoxin; E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GUCY2C (PubMed:1701694). {ECO:0000269|PubMed:1701694}.
uniprot
proteins
mass_dalton
123467
uniprot
proteins
post_translational_modification
PTM: Glycosylation at Asn-74 and/or Asn-78 is required for interaction with VIP36 while glycosylation at Asn-401 modulates ligand-mediated GC-C activation. {ECO:0000250|UniProtKB:P25092}.
uniprot
proteins
protein_family
Adenylyl cyclase class-4/guanylyl cyclase family
uniprot
proteins
pubmed
1701694
uniprot
proteins
sequence_length
1072
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P25092}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P25092}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P25092}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P25092}. Note=The 145 kDa plasma membrane form of GUCY2C contains sialic acid and galactose residues, while a differencially glycosylated 130 Kda form is a high mannose form that is resident in the endoplasmic reticulum and may serve as the precursor for the cell surface form. {ECO:0000250|UniProtKB:P25092}.
uniprot
proteins
transmembrane_region
TRANSMEM 430..453; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins