P31941
uniprot
P31941
canonical
amino_acid_sequence
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
uniprot
proteins
disease_involvement
DISEASE: Note=In the urothelium, antiviral activity of APOBEC3A and APOBEC3B against BK polyomavirus (BKPyV) drives a high burden of mutations in cells proximal to infected neighbors (transmutagenesis), and may be involved in urothelial carcinogenesis. {ECO:0000269|PubMed:41337590}.
uniprot
proteins
ec_number
3.5.4.38
uniprot
proteins
function
FUNCTION: DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. {ECO:0000269|PubMed:10469298, ECO:0000269|PubMed:12859895, ECO:0000269|PubMed:16527742, ECO:0000269|PubMed:19461882, ECO:0000269|PubMed:20062055, ECO:0000269|PubMed:20615867, ECO:0000269|PubMed:21123384, ECO:0000269|PubMed:21368204, ECO:0000269|PubMed:21460793, ECO:0000269|PubMed:21496894, ECO:0000269|PubMed:22457529, ECO:0000269|PubMed:22896697}.
uniprot
proteins
mass_dalton
23012
uniprot
proteins
mutagenesis
MUTAGEN 28; /note="R->E: No effect on deaminase activity despite an altered restriction activity towards genetic invaders."; /evidence="ECO:0000269|PubMed:21123384"; MUTAGEN 29; /note="H->A: Altered deaminase activity and restriction activity towards genetic invaders."; /evidence="ECO:0000269|PubMed:21123384"; MUTAGEN 30; /note="K->F: Altered deaminase activity and restriction activity towards genetic invaders."; /evidence="ECO:0000269|PubMed:21123384"; MUTAGEN 57; /note="N->A: Altered deaminase activity and restriction activity towards genetic invaders."; /evidence="ECO:0000269|PubMed:21123384"; MUTAGEN 60; /note="K->A: Altered deaminase activity and restriction activity towards genetic invaders."; /evidence="ECO:0000269|PubMed:21123384"; MUTAGEN 69; /note="R->A: Altered deaminase activity and restriction activity towards genetic invaders."; /evidence="ECO:0000269|PubMed:21123384"; MUTAGEN 70; /note="H->R: Altered deaminase activity."; /evidence="ECO:0000269|PubMed:16527742"; MUTAGEN 72; /note="E->Q: Altered deaminase activity and restriction activity towards genetic invaders."; /evidence="ECO:0000269|PubMed:16527742, ECO:0000269|PubMed:21123384"; MUTAGEN 98; /note="W->L: Altered deaminase activity and restriction activity towards genetic invaders."; /evidence="ECO:0000269|PubMed:21123384"; MUTAGEN 106; /note="C->S: Altered deaminase activity."; /evidence="ECO:0000269|PubMed:16527742"; MUTAGEN 128; /note="R->A: Altered deaminase activity and restriction activity towards genetic invaders."; /evidence="ECO:0000269|PubMed:21123384"; MUTAGEN 130; /note="Y->A: Altered deaminase activity and restriction activity towards genetic invaders."; /evidence="ECO:0000269|PubMed:21123384"; MUTAGEN 131; /note="D->N: No effect on deaminase activity despite an altered restriction activity towards genetic invaders."; /evidence="ECO:0000269|PubMed:21123384"; MUTAGEN 133; /note="D->N: Altered deaminase activity and restriction activity towards genetic invaders."; /evidence="ECO:0000269|PubMed:21123384"; MUTAGEN 136; /note="Y->A: Altered deaminase activity and restriction activity towards genetic invaders."; /evidence="ECO:0000269|PubMed:21123384
uniprot
proteins
protein_family
Cytidine and deoxycytidylate deaminase family
uniprot
proteins
pubmed
10469298
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
11863358
uniprot
proteins
pubmed
12683974
uniprot
proteins
pubmed
12859895
uniprot
proteins
pubmed
1286667
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16527742
uniprot
proteins
pubmed
18304004
uniprot
proteins
pubmed
19461882
uniprot
proteins
pubmed
20062055
uniprot
proteins
pubmed
20308164
uniprot
proteins
pubmed
20615867
uniprot
proteins
pubmed
21123384
uniprot
proteins
pubmed
21368204
uniprot
proteins
pubmed
21460793
uniprot
proteins
pubmed
21496894
uniprot
proteins
pubmed
21835787
uniprot
proteins
pubmed
22001110
uniprot
proteins
pubmed
22457529
uniprot
proteins
pubmed
22896697
uniprot
proteins
pubmed
22912627
uniprot
proteins
pubmed
22915799
uniprot
proteins
pubmed
22977230
uniprot
proteins
pubmed
41337590
uniprot
proteins
sequence_length
199
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm.
uniprot
proteins