P70645
uniprot
P70645
canonical
amino_acid_sequence
MNNAGLNSEKVAALIQKLNSDPQFVLAQNVGTTHDLLDICLKRATVQGAQHVFQHVVPQEGKPVTNQKSSGRCWIFSCLNVMRLPFMKKFNIEEFEFSQSYLFFWDKVERCYFFLNAFVDTAQKKEPEDGRLVQYLLMNPTNDGGQWDMLVNIVEKYGVVPKKCFPESHTTEATRRMNDILNHKMREFCIRLRNLVHSGATKGEISSTQDAMMEEIFRVVCICLGNPPETFTWEYRDKDKNYHKVGPITPLQFYKEHVKPLFNMEDKICFVNDPRPQHKYNKLYTVDYLSNMVGGRKTLYNNQPIDFLKKMVAASIRDGEAVWFGCDVGKHFNGKLGLSDMNVYDHELVFGVSLKNMNKAERLAFGESLMTHAMTFTAVSEKDDQEGAFVKWRVENSWGEDHGHKGYLCMTDEWFSEYVYEVVVDKKHVPEEVLAVLEQEPIVLPAWDPMGALA
uniprot
proteins
ec_number
3.4.22.40
uniprot
proteins
function
FUNCTION: The normal physiological role of BLM hydrolase is unknown, but it catalyzes the inactivation of the antitumor drug BLM (a glycopeptide) by hydrolyzing the carboxamide bond of its B-aminoalaninamide moiety thus protecting normal and malignant cells from BLM toxicity (By similarity). Binds single-stranded DNA with higher affinity than double-stranded DNA. May play an important role in the metabolism of antibiotics. {ECO:0000250}.
uniprot
proteins
mass_dalton
52323
uniprot
proteins
protein_family
Peptidase C1 family
uniprot
proteins
pubmed
8889821
uniprot
proteins
pubmed
8907172
uniprot
proteins
sequence_length
454
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q13867}. Cytoplasmic granule {ECO:0000250|UniProtKB:Q13867}. Note=Co-localizes with NUDT12 in the cytoplasmic granules. {ECO:0000250|UniProtKB:Q13867}.
uniprot
proteins