Slc22a8
entrez
83500
canonical
uniprot
Q9R1U7
canonical
ensembl
ENSRNOG00000018086
resolver
ensp
ENSRNOP00000084369
resolver
genesymbol
Slc22a8
resolver
genesymbol_syn
Oat3
resolver
uniprot
Q66HN0
resolver
uniprot_entry
S22A8_RAT
resolver
uniprot_sec
Q66HN0
resolver
amino_acid_sequence
MTFSEILDRVGSMGPFQYLHVTLLALPVLGIANHNLLQIFTATTPVHHCRPPPNASIGPWVLPLDPNGKPEKCLRFVHLPNASLPNDTQRATEPCLDGWIYNSTRDTIVIEWDLVCSSNKLKEMAQSIFMAGILVGGPVIGELSDRFGRKPILTWSYLMLAASGSGAAFSPSLPVYMIFRFLCGCSISGISLSTVILNVEWVPTSMRAISSTSIGYCYTIGQFILSGLAYAIPQWRWLQLTSSAPFFIFSLLSWWVPESIRWLVLSGKYSKALKTLQRVATFNGKKEEGKKLTIEELKFNLQKDITSAKVKYGLSDLFRVSILRRVTFCLSLAWFSTGFAYYSLAMGVEEFGVNIYILQIIFGGVDIPAKFITILSLSYLGRRITQSFLLLLAGGAILALIFVPSEMQLLRTALAVFGKGCLSGSFSCLFLYTSELYPTVLRQTGMGISNVWARVGSMIAPLVKITGELQPFIPNVIFGTTALLGGSAAFFLLETLNRPLPETIEDIQNWHKQVQKTKQESEAEKASQIIPLKTGG
uniprot
proteins
function
FUNCTION: Functions as an organic anion/dicarboxylate exchanger that couples organic anion uptake indirectly to the sodium gradient (PubMed:12488248, PubMed:12660303). Transports organic anions such as estrone 3-sulfate (E1S) and urate in exchange for dicarboxylates such as glutarate or ketoglutarate (2-oxoglutarate) (PubMed:12488248, PubMed:12660303, PubMed:23832370). Plays an important role in the excretion of endogenous and exogenous organic anions, especially from the kidney and the brain (PubMed:10224140, PubMed:11961115, PubMed:12684544). E1S transport is pH- and chloride-dependent and may also involve E1S/cGMP exchange (By similarity). Responsible for the transport of prostaglandin E2 (PGE2) and prostaglandin F2(alpha) (PGF2(alpha)) in the basolateral side of the renal tubule (By similarity). Involved in the transport of neuroactive tryptophan metabolites kynurenate and xanthurenate (PubMed:23832370). Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins (By similarity). May be involved in the basolateral transport of steviol, a metabolite of the popular sugar substitute stevioside (By similarity). May participate in the detoxification/ renal excretion of drugs and xenobiotics, such as the histamine H(2)-receptor antagonists fexofenadine and cimetidine, the antibiotic benzylpenicillin (PCG), the anionic herbicide 2,4-dichloro-phenoxyacetate (2,4-D), the diagnostic agent p-aminohippurate (PAH), the antiviral acyclovir (ACV), and the mycotoxin ochratoxin (OTA), by transporting these exogenous organic anions across the cell membrane in exchange for dicarboxylates such as 2-oxoglutarate (By similarity). Contributes to the renal uptake of potent uremic toxins (indoxyl sulfate (IS), indole acetate (IA), hippurate/N-benzoylglycine (HA) and 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF)), pravastatin, PCG, E1S and dehydroepiandrosterone sulfate (DHEAS), and is partly involved in the renal uptake of temocaprilat (an angiotensin-converting enzyme (ACE) inhibitor) (PubMed:11861777, PubMed:12660303, PubMed:14675047, PubMed:15846470). May contribute to the release of cortisol in the adrenals (By similarity). Involved in one of the detoxification systems on the choroid plexus (CP), removes substrates such as E1S or taurocholate (TC), PCG, 2,4-D and PAH, from the cerebrospinal fluid (CSF) to the blood for eventual excretion in urine and bile (PubMed:11961115, PubMed:15319347, PubMed:15389674). Regulates the CSF concentration of histamine H(2)-receptor antagonists cimetidine and ranitidine at the CP (PubMed:15319347). Also contributes to the uptake of several other organic compounds such as the prostanoids prostaglandin E(2) and prostaglandin F(2-alpha), L-carnitine, and the therapeutic drugs allopurinol, 6-mercaptopurine (6-MP) and 5-fluorouracil (5-FU) (By similarity). Mediates the uptake from brain of organic anions, such as E1S, PAH, and OTA (PubMed:10224140, PubMed:11961115). Mediates the transport of PAH, PCG, and the statins pravastatin and pitavastatin, from the cerebrum into the blood circulation across the blood-brain barrier (BBB) (PubMed:11961115, PubMed:12684544, PubMed:15292460). In summary, plays a role in the efflux of drugs and xenobiotics, helping reduce their undesired toxicological effects on the body (PubMed:15292460). {ECO:0000250|UniProtKB:O88909, ECO:0000250|UniProtKB:Q8TCC7, ECO:0000269|PubMed:10224140, ECO:0000269|PubMed:11861777, ECO:0000269|PubMed:11961115, ECO:0000269|PubMed:12488248, ECO:0000269|PubMed:12660303, ECO:0000269|PubMed:12684544, ECO:0000269|PubMed:14675047, ECO:0000269|PubMed:15292460, ECO:0000269|PubMed:15319347, ECO:0000269|PubMed:15389674, ECO:0000269|PubMed:15846470, ECO:0000269|PubMed:23832370, ECO:0000303|PubMed:15292460}.
uniprot
proteins
mass_dalton
59186
uniprot
proteins
protein_family
Major facilitator (TC 2.A.1) superfamily
uniprot
proteins
protein_family
Organic cation transporter (TC 2.A.1.19) family
uniprot
proteins
pubmed
10224140
uniprot
proteins
pubmed
11861777
uniprot
proteins
pubmed
11961115
uniprot
proteins
pubmed
12488248
uniprot
proteins
pubmed
12660303
uniprot
proteins
pubmed
12684544
uniprot
proteins
pubmed
14675047
uniprot
proteins
pubmed
15292460
uniprot
proteins
pubmed
15319347
uniprot
proteins
pubmed
15389674
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15846470
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23832370
uniprot
proteins
sequence_length
536
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:15389674}; Multi-pass membrane protein {ECO:0000305}. Note=Localizes on the brush border membrane of the choroid epithelial cells. Localizes to the basolateral membrane of the proximal tubular cells. Localizes on the abluminal and possibly, luminal membrane of the brain capillary endothelial cells (BCEC). {ECO:0000269|PubMed:11861777, ECO:0000269|PubMed:11961115, ECO:0000269|PubMed:12684544}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 124..144; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 159..179; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 181..201; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 213..233; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 237..257; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 328..348; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 355..375; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 384..404; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 412..432; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 472..492; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins