Dnph1
entrez
381101
canonical
uniprot
Q80VJ3
canonical
ensembl
ENSMUSG00000040658
resolver
ensp
ENSMUSP00000045283
resolver
enst
ENSMUST00000046497
resolver
genesymbol
Dnph1
resolver
uniprot
Q3U9Y7
resolver
uniprot_entry
DNPH1_MOUSE
resolver
uniprot_sec
Q3U9Y7
resolver
amino_acid_sequence
MAASGELVPCSVYFCGSIRGGREDQALYSRIVSRLRRYGKVLTEHVADAELEPRGEEAAGGDQFIHERDLAWLRQADVVVAEVTQPSLGVGYELGRAVALGKPILCLFRPQSGRVLSAMIRGAADGSRFQVWDYAEEEVETMLHRYFEAYLPQGTASSSNPSACLNPTVLEKI
uniprot
proteins
ec_number
3.2.2.-
uniprot
proteins
function
FUNCTION: Part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate). Catalyzes the second step in that pathway, the hydrolysis of the N-glycosidic bond in hmdUMP, degrading this cytotoxic nucleotide to avoid its genomic integration. {ECO:0000250|UniProtKB:O43598}.
uniprot
proteins
mass_dalton
18977
uniprot
proteins
protein_family
2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
173
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O43598}. Nucleus {ECO:0000250|UniProtKB:O43598}.
uniprot
proteins