Elf3
entrez
304815
canonical
uniprot
Q4V7E1
canonical
ensembl
ENSRNOG00000006330
resolver
ensp
ENSRNOP00000008753
resolver
ensp
ENSRNOP00000108675
resolver
enst
ENSRNOT00000008754
resolver
genesymbol
Elf3
resolver
uniprot
A0A8L2Q3H0
resolver
uniprot_entry
A0A8L2Q3H0_RAT
resolver
uniprot_entry
ELF3_RAT
resolver
amino_acid_sequence
MAATCEISNVFSNYFNAMYSSEDPTLAPAPLTTFGTEDFVLTLNNQHMSPEGPVGCVGPQTRSQRDRTEPPAVLHLAEKASWTGERPQFWSKTQVLDWISYQVEKNKYDASSIDFSRCDMDGATLCNCALEELRLVFGPLGDQLHAQLRDLTSSSSDELSWIIELLEKDGMTFQEGLGDSGPFDQGSPFAQELLDDGRQASPYYGSSYGPGAPSPGSSDFSTSGTDTPQSSHSSDSGGSDVDLDLTDSKVFPRDGFPDYKKGEPKHGKRKRGRPRKLSKEYWDCLEGKKSKHAPRGTHLWEFIRDILIHPELNEGLMKWENRHEGVFKFLRSEAVAQLWGQKKKNSNMTYEKLSRAMRYYYKREILERVDGRRLVYKFGKNSSGWKEEEVGESQN
uniprot
proteins
function
FUNCTION: Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity). {ECO:0000250|UniProtKB:P78545, ECO:0000250|UniProtKB:Q3UPW2}.
uniprot
proteins
mass_dalton
44521
uniprot
proteins
protein_family
ETS family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
395
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250|UniProtKB:P78545, ECO:0000255|PROSITE-ProRule:PRU00237}.
uniprot
proteins