Q8VCX6
uniprot
Q8VCX6
canonical
amino_acid_sequence
MGEAAVAEGPCPLLEDSFTRFSSQSNVYGLAGGADGRGELLAATLKGKVLGFRYQDLRQKIRPVAKELQFNYIPVDAEIVSIDTFNKSPPKRGLVVGITFIKDSGDKGSPFLNIYCDYEPGSEYNLDSIAESCLNLELQFTPFQLCHAEVQVGDQLETVFLLSGNDPAIHLYKENEGLHQFEEQPVENLFPELTNLTSSVLWLDVHNLPGSSQRLSALGCQSGYVRVAHVDQKNQEILQTWTIQQDGPISRVIVFSLSASEATQDSPQQEGYSLLVASMLEPAVVYWDLLNKGLDDQLLLPGSDQFDSVLCGLVTDVDLDGQLEVLVATYGQELLCYKYRGLPEDSRGFRLLWRRSFASPLLAMAHVDLTGDGLRELAVISLKGVHILQHSLIQASELVLTRLRHQVEQRKHQQGLGDRVGPRPVEHPAS
uniprot
proteins
function
FUNCTION: As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose. {ECO:0000250|UniProtKB:Q9Y664}.
uniprot
proteins
mass_dalton
47545
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
430
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q9Y664}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q9Y664}. Cell projection, stereocilium {ECO:0000250|UniProtKB:A0A1D5PJB7}. Note=Localization to lysosomes is amino acid-independent (By similarity). Colocalizes with F-actin (By similarity). {ECO:0000250|UniProtKB:Q9Y664}.
uniprot
proteins