Sgpl1
entrez
286896
canonical
uniprot
Q8CHN6
canonical
ensembl
ENSRNOG00000000565
resolver
ensembl
ENSRNOG00055009250
resolver
ensembl
ENSRNOG00060002861
resolver
ensembl
ENSRNOG00065022780
resolver
ensp
ENSRNOP00000102422
resolver
ensp
ENSRNOP00055012612
resolver
ensp
ENSRNOP00060003303
resolver
ensp
ENSRNOP00065031609
resolver
enst
ENSRNOT00055015699
resolver
enst
ENSRNOT00060004632
resolver
enst
ENSRNOT00065038952
resolver
genesymbol
Sgpl1
resolver
genesymbol_syn
Spl
resolver
uniprot_entry
SGPL1_RAT
resolver
amino_acid_sequence
MPSTDLLKLKDFEPYLEILEAYSTKAKNYVNGYCTKYEPWQLIAGSVLCTLLVVWVYELIFQPESLWSRFKNKLFRLIRKMPFIGRKIQQQLTKAKKDLVKNMPFLKLDKDYVKTLPAQGLSTAEVLERLKEYSSMDVFWQEGKASGAVYSGEPKLTELLVQAYGEFTWSNPLHPDIFPGLRKLEAEIVRMTCSLFNGGPDSCGCVTSGGTESILMACKAYRDLALEKGIKTPEIVAPESAHAAFDKAAHYFGMKIVRVAQKKNMEVDVRAMKRAISRNTAMLVCSAPQFPHGVIDPIPEVAKLAVKYKIPFHVDACLGGFLIVFMEKAGYPLEKPFDFRVKGVTSISADTHKYGYAPKGSSVVMYSNEKYRKYQFFVDADWQGGIYASPSIAGSRPGGIIAACWAALMHFGENGYVEATKQIIKTARFLKSELENIKNIFILGDPQLSVIALGSNDFDIYRLSNMMSAKGWNFNYLQFPRSIHFCITLVHTRKRVAIQFLKDIRESVTQIMKNPKAKTTGMGAIYGMAQATIDRKMVAEISSVFLDSLYSTDPVTQGNQMNGSPKPR
uniprot
proteins
ec_number
4.1.2.27
uniprot
proteins
function
FUNCTION: Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis (By similarity). Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP (By similarity). Seems to play a role in establishing neuronal contact sites and axonal maintenance (By similarity). {ECO:0000250|UniProtKB:O95470, ECO:0000250|UniProtKB:Q8R0X7, ECO:0000250|UniProtKB:Q9V7Y2}.
uniprot
proteins
mass_dalton
63758
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; sphingolipid metabolism. {ECO:0000250|UniProtKB:O95470}.
uniprot
proteins
protein_family
Group II decarboxylase family
uniprot
proteins
protein_family
Sphingosine-1-phosphate lyase subfamily
uniprot
proteins
sequence_length
568
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O95470}; Single-pass type III membrane protein {ECO:0000255}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8R0X7}.
uniprot
proteins
transmembrane_region
TRANSMEM 42..62; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins