FXYD3
entrez
5349
canonical
uniprot
Q14802
canonical
ensembl
ENSG00000089356
resolver
ensembl
ENSG00000285526
resolver
ensp
ENSP00000389770
resolver
ensp
ENSP00000473929
resolver
ensp
ENSP00000474055
resolver
ensp
ENSP00000474223
resolver
ensp
ENSP00000474438
resolver
ensp
ENSP00000474526
resolver
ensp
ENSP00000474622
resolver
ensp
ENSP00000474851
resolver
ensp
ENSP00000474855
resolver
ensp
ENSP00000475056
resolver
ensp
ENSP00000544756
resolver
ensp
ENSP00000544757
resolver
ensp
ENSP00000544763
resolver
ensp
ENSP00000544765
resolver
ensp
ENSP00000544770
resolver
enst
ENST00000603524
resolver
enst
ENST00000604804
resolver
enst
ENST00000874704
resolver
genesymbol
FXYD3
resolver
genesymbol_syn
MAT8
resolver
genesymbol_syn
PLML
resolver
hgnc
HGNC:4027
resolver
uniprot
A0A1S5UZ23
resolver
uniprot
A6NDE0
resolver
uniprot
C9JDU2
resolver
uniprot
F5H174
resolver
uniprot
F8WB34
resolver
uniprot
Q13211
resolver
uniprot
Q6IB59
resolver
uniprot
S4R445
resolver
uniprot_entry
A0A1S5UZ23_HUMAN
resolver
uniprot_entry
FXYD3_HUMAN
resolver
uniprot_entry
S4R445_HUMAN
resolver
uniprot_sec
A6NDE0
resolver
uniprot_sec
C9JDU2
resolver
uniprot_sec
F5H174
resolver
uniprot_sec
F8WB34
resolver
uniprot_sec
Q13211
resolver
uniprot_sec
Q6IB59
resolver
amino_acid_sequence
MQKVTLGLLVFLAGFPVLDANDLEDKNSPFYYDWHSLQVGGLICAGVLCAMGIIIVMSAKCKCKFGQKSGHHPGETPPLITPGSAQS
uniprot
proteins
function
FUNCTION: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell (PubMed:17077088). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (PubMed:21454534). Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes (PubMed:7836447). {ECO:0000269|PubMed:17077088, ECO:0000269|PubMed:21454534, ECO:0000269|PubMed:7836447}.; FUNCTION: [Isoform 1]: Decreases the apparent K+ and Na+ affinity of the sodium/potassium-transporting ATPase over a large range of membrane potentials. {ECO:0000269|PubMed:17077088}.; FUNCTION: [Isoform 2]: Decreases the apparent K+ affinity of the sodium/potassium-transporting ATPase only at slightly negative and positive membrane potentials and increases the apparent Na+ affinity over a large range of membrane potentials. {ECO:0000269|PubMed:17077088}.
uniprot
proteins
mass_dalton
9263
uniprot
proteins
mutagenesis
MUTAGEN 44; /note="C->S: Abolishes glutathionylation but does not affect interaction with ATP1B1; when associated with S-49; S-61 and S-63."; /evidence="ECO:0000269|PubMed:21454534"; MUTAGEN 49; /note="C->S: Abolishes glutathionylation but does not affect interaction with ATP1B1; when associated with S-43; S-61 and S-63."; /evidence="ECO:0000269|PubMed:21454534"; MUTAGEN 61; /note="C->S: Abolishes glutathionylation but does not affect interaction with ATP1B1; when associated with S-43; S-49 and S-63."; /evidence="ECO:0000269|PubMed:21454534"; MUTAGEN 63; /note="C->S: Abolishes glutathionylation but does not affect interaction with ATP1B1; when associated with S-43; S-49 and S-61."; /evidence="ECO:0000269|PubMed:21454534
uniprot
proteins
post_translational_modification
PTM: Glutathionylated. {ECO:0000269|PubMed:21454534}.
uniprot
proteins
protein_family
FXYD family
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17077088
uniprot
proteins
pubmed
21454534
uniprot
proteins
pubmed
7836447
uniprot
proteins
sequence_length
87
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 39..59; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins