Defal1
entrez
613220
canonical
uniprot
Q4JEI2
canonical
ensembl
ENSRNOG00000029462
resolver
ensembl
ENSRNOG00060025193
resolver
ensp
ENSRNOP00000047361
resolver
ensp
ENSRNOP00060036151
resolver
enst
ENSRNOT00000049394
resolver
enst
ENSRNOT00060043604
resolver
genesymbol
Defal1
resolver
genesymbol_syn
Defa-rs1
resolver
uniprot_entry
DFAL1_RAT
resolver
amino_acid_sequence
MKTLILLSALVLLALQVQADPIQEAEEETKTEEQPADEDQDVSVSFEGPEASAVQDLRVRRTLQCSCRRVCRNTCSCIRLSRSTYAS
uniprot
proteins
function
FUNCTION: Intestinal defense peptide (PubMed:23380721, PubMed:28345637). Has potent antibacterial activity against Gram-negative bacteria E.coli O157:H7, S.typhimurium DT104, and K.pneumoniae; and against Gram-positive bacteria S.aureus, methicillin-resistant S.aureus and L.monocytogenes (PubMed:23380721, PubMed:28345637). Remains active in the presence of NaCl and Mg(2+) (PubMed:23380721). Probably functions by disrupting bacterial membrane integrity (PubMed:28345637). However, does not show cytotoxic activity towards human intestinal cells (PubMed:23380721). {ECO:0000269|PubMed:23380721, ECO:0000269|PubMed:28345637}.
uniprot
proteins
mass_dalton
9702
uniprot
proteins
mutagenesis
MUTAGEN 71; /note="C->S: Aberrant protein folding and disordered structure."; /evidence="ECO:0000269|PubMed:28345637
uniprot
proteins
protein_family
Alpha-defensin family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15494476
uniprot
proteins
pubmed
23380721
uniprot
proteins
pubmed
28345637
uniprot
proteins
sequence_length
87
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:23380721, ECO:0000305|PubMed:28345637}.
uniprot
proteins