Irf8
entrez
15900
canonical
uniprot
P23611
canonical
ensembl
ENSMUSG00000041515
resolver
ensp
ENSMUSP00000040245
resolver
ensp
ENSMUSP00000125029
resolver
enst
ENSMUST00000047737
resolver
enst
ENSMUST00000162001
resolver
genesymbol
Irf8
resolver
genesymbol_syn
Icsbp
resolver
genesymbol_syn
Icsbp1
resolver
uniprot
Q3UCV9
resolver
uniprot
Q544J7
resolver
uniprot_entry
IRF8_MOUSE
resolver
uniprot_entry
Q3UCV9_MOUSE
resolver
uniprot_entry
Q544J7_MOUSE
resolver
amino_acid_sequence
MCDRNGGRRLRQWLIEQIDSSMYPGLIWENDEKTMFRIPWKHAGKQDYNQEVDASIFKAWAVFKGKFKEGDKAEPATWKTRLRCALNKSPDFEEVTDRSQLDISEPYKVYRIVPEEEQKCKLGVAPAGCMSEVPEMECGRSEIEELIKEPSVDEYMGMTKRSPSPPEACRSQILPDWWVQQPSAGLPLVTGYAAYDTHHSAFSQMVISFYYGGKLVGQATTTCLEGCRLSLSQPGLPKLYGPDGLEPVCFPTADTIPSERQRQVTRKLFGHLERGVLLHSNRKGVFVKRLCQGRVFCSGNAVVCKGRPNKLERDEVVQVFDTNQFIRELQQFYATQSRLPDSRVVLCFGEEFPDTVPLRSKLILVQVEQLYARQLVEEAGKSCGAGSLMPALEEPQPDQAFRMFPDICTSHQRPFFRENQQITV
uniprot
proteins
function
FUNCTION: Transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) (PubMed:12393690, PubMed:2111015). Can both act as a transcriptional activator or repressor (PubMed:2111015). Plays a negative regulatory role in cells of the immune system (PubMed:2111015). Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF8 and activation of genes (PubMed:12393690, PubMed:22992524). Required for the development of plasmacytoid dendritic cells (pDCs), which produce most of the type I IFN in response to viral infection (PubMed:12393690, PubMed:12461077, PubMed:12538667, PubMed:23382217). Positively regulates macroautophagy in dendritic cells (By similarity). Acts as a transcriptional repressor of osteoclast differentiation factors such as NFATC1 and EEIG1 (PubMed:32741026). {ECO:0000250|UniProtKB:Q02556, ECO:0000269|PubMed:12393690, ECO:0000269|PubMed:12461077, ECO:0000269|PubMed:12538667, ECO:0000269|PubMed:2111015, ECO:0000269|PubMed:22992524, ECO:0000269|PubMed:23382217, ECO:0000269|PubMed:32741026}.
uniprot
proteins
mass_dalton
48237
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated (PubMed:17579016). Ubiquitination by TRIM21 in macrophages, a process that is strongly increased upon interferon gamma stimulation, leds to the enhanced transcriptional activity of target cytokine genes (PubMed:17579016). Ubiquitination leads to its degradation by the proteasome (By similarity). {ECO:0000250|UniProtKB:Q02556, ECO:0000269|PubMed:17579016}.; PTM: Sumoylated with SUMO3. Desumoylated by SENP1. {ECO:0000250|UniProtKB:Q02556}.
uniprot
proteins
protein_family
IRF family
uniprot
proteins
pubmed
12393690
uniprot
proteins
pubmed
12461077
uniprot
proteins
pubmed
12538667
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17579016
uniprot
proteins
pubmed
2111015
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22992524
uniprot
proteins
pubmed
23382217
uniprot
proteins
pubmed
32741026
uniprot
proteins
sequence_length
424
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17579016}. Cytoplasm {ECO:0000250|UniProtKB:Q02556}. Note=In resting macrophages, localizes in the cytoplasm. Translocated in the nucleus upon IFN-gamma induction. {ECO:0000250|UniProtKB:Q02556}.
uniprot
proteins