PIF1
entrez
80119
canonical
uniprot
Q9H611
canonical
ensembl
ENSG00000140451
resolver
ensp
ENSP00000268043
resolver
ensp
ENSP00000328174
resolver
ensp
ENSP00000452792
resolver
ensp
ENSP00000754239
resolver
genesymbol
PIF1
resolver
genesymbol_syn
C15orf20
resolver
hgnc
HGNC:26220
resolver
uniprot
B2RPL7
resolver
uniprot
Q1W5B6
resolver
uniprot
Q330H5
resolver
uniprot
Q33E24
resolver
uniprot_entry
PIF1_HUMAN
resolver
uniprot_sec
B2RPL7
resolver
uniprot_sec
Q1W5B6
resolver
uniprot_sec
Q330H5
resolver
uniprot_sec
Q33E24
resolver
amino_acid_sequence
MLSGIEAAAGEYEDSELRCRVAVEELSPGGQPRRRQALRTAELSLGRNERRELMLRLQAPGPAGRPRCFPLRAARLFTRFAEAGRSTLRLPAHDTPGAGAVQLLLSDCPPDRLRRFLRTLRLKLAAAPGPGPASARAQLLGPRPRDFVTISPVQPEERRLRAATRVPDTTLVKRPVEPQAGAEPSTEAPRWPLPVKRLSLPSTKPQLSEEQAAVLRAVLKGQSIFFTGSAGTGKSYLLKRILGSLPPTGTVATASTGVAACHIGGTTLHAFAGIGSGQAPLAQCVALAQRPGVRQGWLNCQRLVIDEISMVEADLFDKLEAVARAVRQQNKPFGGIQLIICGDFLQLPPVTKGSQPPRFCFQSKSWKRCVPVTLELTKVWRQADQTFISLLQAVRLGRCSDEVTRQLQATASHKVGRDGIVATRLCTHQDDVALTNERRLQELPGKVHRFEAMDSNPELASTLDAQCPVSQLLQLKLGAQVMLVKNLSVSRGLVNGARGVVVGFEAEGRGLPQVRFLCGVTEVIHADRWTVQATGGQLLSRQQLPLQLAWAMSIHKSQGMTLDCVEISLGRVFASGQAYVALSRARSLQGLRVLDFDPMAVRCDPRVLHFYATLRRGRSLSLESPDDDEAASDQENMDPIL
uniprot
proteins
ec_number
5.6.2.3
uniprot
proteins
function
FUNCTION: DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity. {ECO:0000255|HAMAP-Rule:MF_03176, ECO:0000269|PubMed:16522649, ECO:0000269|PubMed:17172855, ECO:0000269|PubMed:17827721, ECO:0000269|PubMed:18835853, ECO:0000269|PubMed:19700773, ECO:0000269|PubMed:20524933, ECO:0000269|PubMed:23657261}.
uniprot
proteins
mass_dalton
69799
uniprot
proteins
mutagenesis
MUTAGEN 234; /note="K->A: Loss of ATPase activity. Lower activity for single-stranded DNA."; /evidence="ECO:0000269|PubMed:16522649
uniprot
proteins
protein_family
Helicase family
uniprot
proteins
protein_family
PIF1 subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16522649
uniprot
proteins
pubmed
17172855
uniprot
proteins
pubmed
17827721
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18835853
uniprot
proteins
pubmed
19700773
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20524933
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23275553
uniprot
proteins
pubmed
23657261
uniprot
proteins
sequence_length
641
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03176, ECO:0000269|PubMed:16522649, ECO:0000269|PubMed:17172855, ECO:0000269|PubMed:17827721}.; SUBCELLULAR LOCATION: [Isoform 4]: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03176, ECO:0000269|PubMed:23275553}.
uniprot
proteins