SLC38A1
entrez
81539
canonical
uniprot
Q9H2H9
canonical
ensembl
ENSG00000111371
resolver
ensp
ENSP00000381634
resolver
ensp
ENSP00000398142
resolver
ensp
ENSP00000447853
resolver
ensp
ENSP00000449607
resolver
ensp
ENSP00000449756
resolver
ensp
ENSP00000478907
resolver
ensp
ENSP00000521756
resolver
ensp
ENSP00000521757
resolver
ensp
ENSP00000521758
resolver
ensp
ENSP00000521759
resolver
ensp
ENSP00000521760
resolver
ensp
ENSP00000521761
resolver
ensp
ENSP00000521762
resolver
ensp
ENSP00000521763
resolver
ensp
ENSP00000521764
resolver
ensp
ENSP00000521765
resolver
ensp
ENSP00000521767
resolver
ensp
ENSP00000521768
resolver
ensp
ENSP00000521769
resolver
ensp
ENSP00000521770
resolver
ensp
ENSP00000521771
resolver
ensp
ENSP00000521772
resolver
ensp
ENSP00000521773
resolver
ensp
ENSP00000521774
resolver
ensp
ENSP00000521775
resolver
ensp
ENSP00000521776
resolver
ensp
ENSP00000592875
resolver
ensp
ENSP00000592876
resolver
ensp
ENSP00000592877
resolver
ensp
ENSP00000592878
resolver
ensp
ENSP00000592879
resolver
ensp
ENSP00000625663
resolver
ensp
ENSP00000657114
resolver
ensp
ENSP00000657115
resolver
ensp
ENSP00000688932
resolver
ensp
ENSP00000688934
resolver
ensp
ENSP00000688935
resolver
ensp
ENSP00000688936
resolver
enst
ENST00000398637
resolver
enst
ENST00000439706
resolver
enst
ENST00000546893
resolver
enst
ENST00000549049
resolver
enst
ENST00000552197
resolver
enst
ENST00000612161
resolver
enst
ENST00000851697
resolver
enst
ENST00000851698
resolver
enst
ENST00000851699
resolver
enst
ENST00000851700
resolver
enst
ENST00000851701
resolver
enst
ENST00000851702
resolver
enst
ENST00000851703
resolver
enst
ENST00000851704
resolver
enst
ENST00000851705
resolver
enst
ENST00000851706
resolver
enst
ENST00000851708
resolver
enst
ENST00000851709
resolver
enst
ENST00000851710
resolver
enst
ENST00000851711
resolver
enst
ENST00000851712
resolver
enst
ENST00000851713
resolver
enst
ENST00000851714
resolver
enst
ENST00000851715
resolver
enst
ENST00000851716
resolver
enst
ENST00000851717
resolver
enst
ENST00000922816
resolver
enst
ENST00000922817
resolver
enst
ENST00000922818
resolver
enst
ENST00000922819
resolver
enst
ENST00000922820
resolver
enst
ENST00000955604
resolver
genesymbol
SLC38A1
resolver
genesymbol_syn
ATA1
resolver
genesymbol_syn
NAT2
resolver
genesymbol_syn
SAT1
resolver
genesymbol_syn
SNAT1
resolver
hgnc
HGNC:13447
resolver
uniprot
F8VX04
resolver
uniprot
Q8NC61
resolver
uniprot
Q8NCF8
resolver
uniprot
Q96JX2
resolver
uniprot
Q9H2Q2
resolver
uniprot_entry
F8VX04_HUMAN
resolver
uniprot_entry
S38A1_HUMAN
resolver
uniprot_sec
Q8NC61
resolver
uniprot_sec
Q8NCF8
resolver
uniprot_sec
Q96JX2
resolver
uniprot_sec
Q9H2Q2
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by alpha-(methylamino)isobutyric acid (MeAIB). Inhibited by lithium, potassium, choline ions, N-methylglucamine. The pH dependence has an allosteric effect on the transport. {ECO:0000250|UniProtKB:Q9JM15}.
uniprot
proteins
amino_acid_sequence
MMHFKSGLELTELQNMTVPEDDNISNDSNDFTEVENGQINSKFISDRESRRSLTNSHLEKKKCDEYIPGTTSLGMSVFNLSNAIMGSGILGLAFALANTGILLFLVLLTSVTLLSIYSINLLLICSKETGCMVYEKLGEQVFGTTGKFVIFGATSLQNTGAMLSYLFIVKNELPSAIKFLMGKEETFSAWYVDGRVLVVIVTFGIILPLCLLKNLGYLGYTSGFSLSCMVFFLIVVIYKKFQIPCIVPELNSTISANSTNADTCTPKYVTFNSKTVYALPTIAFAFVCHPSVLPIYSELKDRSQKKMQMVSNISFFAMFVMYFLTAIFGYLTFYDNVQSDLLHKYQSKDDILILTVRLAVIVAVILTVPVLFFTVRSSLFELAKKTKFNLCRHTVVTCILLVVINLLVIFIPSMKDIFGVVGVTSANMLIFILPSSLYLKITDQDGDKGTQRIWAALFLGLGVLFSLVSIPLVIYDWACSSSSDEGH
uniprot
proteins
function
FUNCTION: Symporter that cotransports short-chain neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane (PubMed:10891391, PubMed:20599747). The transport is elctrogenic, pH dependent and driven by the Na(+) electrochemical gradient (PubMed:10891391). Participates in the astroglia-derived glutamine transport into GABAergic interneurons for neurotransmitter GABA de novo synthesis (By similarity). May also contributes to amino acid transport in placental trophoblasts (PubMed:20599747). Also regulates synaptic plasticity (PubMed:12388062). {ECO:0000250|UniProtKB:Q8K2P7, ECO:0000250|UniProtKB:Q9JM15, ECO:0000269|PubMed:10891391, ECO:0000269|PubMed:12388062, ECO:0000269|PubMed:20599747}.
uniprot
proteins
mass_dalton
54048
uniprot
proteins
post_translational_modification
PTM: N-glycosylation plays an important role in the L-glutamine transport. {ECO:0000250|UniProtKB:Q8K2P7}.
uniprot
proteins
protein_family
Amino acid/polyamine transporter 2 family
uniprot
proteins
pubmed
10891391
uniprot
proteins
pubmed
12388062
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15054072
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16148032
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
16583402
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20599747
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
487
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15054072}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9JM15}. Note=Restricted to the somatodendritic compartment of neurons. Found in the cellular processes of neurons in the developing brain. {ECO:0000250|UniProtKB:Q9JM15}.
uniprot
proteins
transmembrane_region
TRANSMEM 75..97; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 113..133; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 148..168; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 189..211; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 217..237; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 276..296; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 313..333; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 351..371; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 394..414; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 417..437; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 453..473; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins