KPNA2
entrez
3838
canonical
uniprot
P52292
canonical
ensembl
ENSG00000182481
resolver
ensp
ENSP00000332455
resolver
ensp
ENSP00000438483
resolver
ensp
ENSP00000462331
resolver
ensp
ENSP00000463602
resolver
ensp
ENSP00000504655
resolver
ensp
ENSP00000504685
resolver
ensp
ENSP00000583696
resolver
ensp
ENSP00000583698
resolver
enst
ENST00000330459
resolver
enst
ENST00000537025
resolver
enst
ENST00000579754
resolver
enst
ENST00000584026
resolver
enst
ENST00000677086
resolver
enst
ENST00000679078
resolver
enst
ENST00000913637
resolver
enst
ENST00000913639
resolver
genesymbol
KPNA2
resolver
genesymbol_syn
RCH1
resolver
genesymbol_syn
SRP1
resolver
hgnc
HGNC:6395
resolver
uniprot
B9EJD6
resolver
uniprot
Q53YE3
resolver
uniprot
Q6NVW7
resolver
uniprot
Q9BRU5
resolver
uniprot_entry
IMA1_HUMAN
resolver
uniprot_sec
B9EJD6
resolver
uniprot_sec
Q53YE3
resolver
uniprot_sec
Q6NVW7
resolver
uniprot_sec
Q9BRU5
resolver
amino_acid_sequence
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
uniprot
proteins
function
FUNCTION: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1 (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Binds specifically and directly to substrates containing either a simple or bipartite NLS motif (PubMed:28991411, PubMed:32130408, PubMed:7604027, PubMed:7754385). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:7604027, PubMed:7754385). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediator of PR-DUB complex component BAP1 nuclear import; acts redundantly with KPNA1 and Transportin-1/TNPO1 (PubMed:35446349). {ECO:0000269|PubMed:28991411, ECO:0000269|PubMed:32130408, ECO:0000269|PubMed:35446349, ECO:0000269|PubMed:7604027, ECO:0000269|PubMed:7754385}.
uniprot
proteins
mass_dalton
57862
uniprot
proteins
mutagenesis
MUTAGEN 2..80; /note="Missing: Complete loss of binding to KPNB1."; /evidence="ECO:0000269|PubMed:17596301"; MUTAGEN 192; /note="D->A,K: Does not affect association with KAT8 target protein."; /evidence="ECO:0000269|PubMed:28991411"; MUTAGEN 396; /note="E->A,R: Decreased association with KAT8 target protein."; /evidence="ECO:0000269|PubMed:28991411
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Deubiquitinated by USP22; leading to stabilization and increased activity. {ECO:0000269|PubMed:32130408}.
uniprot
proteins
protein_family
Importin alpha family
uniprot
proteins
pubmed
10353244
uniprot
proteins
pubmed
10612665
uniprot
proteins
pubmed
10980193
uniprot
proteins
pubmed
11735022
uniprot
proteins
pubmed
11840567
uniprot
proteins
pubmed
11882654
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15942031
uniprot
proteins
pubmed
16188882
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17596301
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19386897
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20147401
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21385873
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21454664
uniprot
proteins
pubmed
21690087
uniprot
proteins
pubmed
21699900
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28991411
uniprot
proteins
pubmed
29042515
uniprot
proteins
pubmed
30814284
uniprot
proteins
pubmed
30848123
uniprot
proteins
pubmed
32130408
uniprot
proteins
pubmed
32979938
uniprot
proteins
pubmed
35446349
uniprot
proteins
pubmed
36647821
uniprot
proteins
pubmed
7604027
uniprot
proteins
pubmed
7754385
uniprot
proteins
pubmed
8016130
uniprot
proteins
pubmed
8617227
uniprot
proteins
pubmed
9020106
uniprot
proteins
pubmed
9323134
uniprot
proteins
pubmed
9463369
uniprot
proteins
pubmed
9786944
uniprot
proteins
sequence_length
529
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:30814284, ECO:0000269|PubMed:7604027, ECO:0000269|PubMed:9020106}. Nucleus {ECO:0000269|PubMed:7604027, ECO:0000269|PubMed:9020106}.; SUBCELLULAR LOCATION: Endoplasmic reticulum membrane. Golgi apparatus membrane {ECO:0000269|PubMed:17596301}. Note=(Microbial infection) Retained in ER/Golgi membranes upon interaction with SARS-COV virus ORF6 protein. {ECO:0000269|PubMed:17596301}.
uniprot
proteins