Cd84
entrez
12523
canonical
uniprot
Q18PI6
canonical
ensembl
ENSMUSG00000038147
resolver
ensp
ENSMUSP00000115674
resolver
ensp
ENSMUSP00000120881
resolver
ensp
ENSMUSP00000122951
resolver
enst
ENSMUST00000135386
resolver
enst
ENSMUST00000136479
resolver
enst
ENSMUST00000155802
resolver
genesymbol
Cd84
resolver
genesymbol_syn
Slamf5
resolver
uniprot
A0A0R4J0K5
resolver
uniprot
A0A0R4J1S4
resolver
uniprot
E9Q9E8
resolver
uniprot
Q18PI7
resolver
uniprot
Q3TBT1
resolver
uniprot
Q3U0A2
resolver
uniprot
Q8BFV0
resolver
uniprot
Q9Z178
resolver
uniprot_entry
A0A0R4J0K5_MOUSE
resolver
uniprot_entry
A0A0R4J1S4_MOUSE
resolver
uniprot_entry
E9Q9E8_MOUSE
resolver
uniprot_entry
SLAF5_MOUSE
resolver
uniprot_sec
Q18PI7
resolver
uniprot_sec
Q3TBT1
resolver
uniprot_sec
Q3U0A2
resolver
uniprot_sec
Q8BFV0
resolver
uniprot_sec
Q9Z178
resolver
amino_acid_sequence
MAQRHLWIWFLCLQTWSEAAGKDADPMVMNGILGESVTFLLNIQEPKKIDNIAWTSQSSVAFIKPGVNKAEVTITQGTYKGRIEIIDQKYDLVIRDLRMEDAGTYKADINEENEETITKIYYLHIYRRLKTPKITQSLISSLNNTCNITLTCSVEKEEKDVTYSWSPFGEKSNVLQIVHSPMDQKLTYTCTAQNPVSNSSDSVTVQQPCTDTPSFHPRHAVLPGGLAVLFLLILIPMLAFLFRLYKRRRDRIVLEADDVSKKTVYAVVSRNAQPTESRIYDEIPQSKMLSCKEDPVTTIYSSVQLSEKMKETNMKDRSLPKALGNEIVV
uniprot
proteins
function
FUNCTION: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2 (PubMed:20962259). Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B (PubMed:20962259). Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seen be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A/SAP-dependent pathway. May serve as a marker for hematopoietic progenitor cells (By similarity). Required for a prolonged T-cell:B-cell contact, optimal T follicular helper function, and germinal center formation (PubMed:20153220). In germinal centers involved in maintaining B cell tolerance and in preventing autoimmunity (PubMed:25801429). In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 (By similarity). In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2 (PubMed:20628063). Positively regulates macroautophagy in primary dendritic cells via stabilization of IRF8; inhibits TRIM21-mediated proteasomal degradation of IRF8 (By similarity). {ECO:0000250|UniProtKB:Q9UIB8, ECO:0000269|PubMed:16037392, ECO:0000269|PubMed:20153220, ECO:0000269|PubMed:20628063, ECO:0000269|PubMed:20962259, ECO:0000269|PubMed:25801429, ECO:0000305}.
uniprot
proteins
mass_dalton
37378
uniprot
proteins
mutagenesis
MUTAGEN 265; /note="Y->F: No effect on macrophage cytokine secretion."; /evidence="ECO:0000269|PubMed:20628063"; MUTAGEN 300; /note="Y->F: Modulates macrophage cytokine secretion."; /evidence="ECO:0000269|PubMed:20628063
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by tyrosine-protein kinase LCK on tyrosine residues following ligation induced by agonist monoclonal antibody. The association with SH2D1A/SAP is dependent of tyrosine phosphorylation of its cytoplasmic domain. Phosphorylated on Tyr-280 and Tyr-300 following platelet aggregation. Phosphorylated on tyrosine residues upon high affinity immunoglobulin epsilon receptor aggregation in mast cells. {ECO:0000250|UniProtKB:Q9UIB8}.; PTM: N-glycosylated. {ECO:0000250}.
uniprot
proteins
pubmed
10079287
uniprot
proteins
pubmed
11689425
uniprot
proteins
pubmed
16037392
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20153220
uniprot
proteins
pubmed
20628063
uniprot
proteins
pubmed
20962259
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25801429
uniprot
proteins
sequence_length
329
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 222..242; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins