IPO4
entrez
79711
canonical
uniprot
Q8TEX9
canonical
ensembl
ENSG00000196497
resolver
ensembl
ENSG00000285248
resolver
ensp
ENSP00000346453
resolver
genesymbol
IPO4
resolver
genesymbol_syn
IMP4B
resolver
genesymbol_syn
RANBP4
resolver
hgnc
HGNC:19426
resolver
uniprot
B2RN95
resolver
uniprot
B3KT38
resolver
uniprot
Q2NL96
resolver
uniprot
Q86TZ9
resolver
uniprot
Q8NCG8
resolver
uniprot
Q96SJ3
resolver
uniprot
Q9BTI4
resolver
uniprot
Q9H5L0
resolver
uniprot_entry
B3KT38_HUMAN
resolver
uniprot_entry
IPO4_HUMAN
resolver
uniprot_sec
B2RN95
resolver
uniprot_sec
Q2NL96
resolver
uniprot_sec
Q86TZ9
resolver
uniprot_sec
Q8NCG8
resolver
uniprot_sec
Q96SJ3
resolver
uniprot_sec
Q9BTI4
resolver
uniprot_sec
Q9H5L0
resolver
amino_acid_sequence
MESAGLEQLLRELLLPDTERIRRATEQLQIVLRAPAALPALCDLLASAADPQIRQFAAVLTRRRLNTRWRRLAAEQRESLKSLILTALQRETEHCVSLSLAQLSATIFRKEGLEAWPQLLQLLQHSTHSPHSPEREMGLLLLSVVVTSRPEAFQPHHRELLRLLNETLGEVGSPGLLFYSLRTLTTMAPYLSTEDVPLARMLVPKLIMAMQTLIPIDEAKACEALEALDELLESEVPVITPYLSEVLTFCLEVARNVALGNAIRIRILCCLTFLVKVKSKALLKNRLLPPLLHTLFPIVAAEPPPGQLDPEDQDSEEEELEIELMGETPKHFAVQVVDMLALHLPPEKLCPQLMPMLEEALRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAALFALGQFSENLQPHISSYSREVMPLLLAYLKSVPLGHTHHLAKACYALENFVENLGPKVQPYLPELMECMLQLLRNPSSPRAKELAVSALGAIATAAQASLLPYFPAIMEHLREFLLTGREDLQPVQIQSLETLGVLARAVGEPMRPLAEECCQLGLGLCDQVDDPDLRRCTYSLFAALSGLMGEGLAPHLEQITTLMLLSLRSTEGIVPQYDGSSSFLLFDDESDGEEEEELMDEDVEEEDDSEISGYSVENAFFDEKEDTCAAVGEISVNTSVAFLPYMESVFEEVFKLLECPHLNVRKAAHEALGQFCCALHKACQSCPSEPNTAALQAALARVVPSYMQAVNRERERQVVMAVLEALTGVLRSCGTLTLKPPGRLAELCGVLKAVLQRKTACQDTDEEEEEEDDDQAEYDAMLLEHAGEAIPALAAAAGGDSFAPFFAGFLPLLVCKTKQGCTVAEKSFAVGTLAETIQGLGAASAQFVSRLLPVLLSTAQEADPEVRSNAIFGMGVLAEHGGHPAQEHFPKLLGLLFPLLARERHDRVRDNICGALARLLMASPTRKPEPQVLAALLHALPLKEDLEEWVTIGRLFSFLYQSSPDQVIDVAPELLRICSLILADNKIPPDTKAALLLLLTFLAKQHTDSFQAALGSLPVDKAQELQAVLGLS
uniprot
proteins
function
FUNCTION: Nuclear transport receptor that mediates nuclear import of proteins, such as histones, RPS3A, TNP2 and VDR (PubMed:11823430, PubMed:16207705, PubMed:17682055, PubMed:21454524, PubMed:30177573). Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:11823430, PubMed:16207705). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11823430, PubMed:16207705). At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran (PubMed:11823430). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11823430). Mediates the nuclear import of the histone H3-H4 dimer when in complex with ASF1 (ASF1A or ASF1B) (PubMed:21454524, PubMed:29408485, PubMed:36103578). Also mediates the nuclear import of monomeric histones H3.1 and H4 (PubMed:30177573). Mediates the ligand-independent nuclear import of vitamin D receptor (VDR) (PubMed:16207705). In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS (PubMed:12610148). {ECO:0000269|PubMed:11823430, ECO:0000269|PubMed:12610148, ECO:0000269|PubMed:16207705, ECO:0000269|PubMed:17682055, ECO:0000269|PubMed:21454524, ECO:0000269|PubMed:29408485, ECO:0000269|PubMed:30177573, ECO:0000269|PubMed:36103578}.
uniprot
proteins
mass_dalton
118715
uniprot
proteins
protein_family
Importin beta family
uniprot
proteins
pubmed
11823430
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
12610148
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16207705
uniprot
proteins
pubmed
17682055
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21454524
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22407294
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
29408485
uniprot
proteins
pubmed
30177573
uniprot
proteins
pubmed
36103578
uniprot
proteins
sequence_length
1081
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16207705, ECO:0000269|PubMed:17682055, ECO:0000269|PubMed:30177573}. Nucleus {ECO:0000269|PubMed:16207705, ECO:0000269|PubMed:17682055, ECO:0000269|PubMed:30177573}.
uniprot
proteins