Atp6v0a4
entrez
140494
canonical
uniprot
Q920R6
canonical
ensembl
ENSMUSG00000038600
resolver
ensp
ENSMUSP00000039381
resolver
ensp
ENSMUSP00000110558
resolver
enst
ENSMUST00000040259
resolver
enst
ENSMUST00000114908
resolver
genesymbol
Atp6v0a4
resolver
genesymbol_syn
Atp6n1b
resolver
uniprot
Q3UP55
resolver
uniprot
Q8CJ79
resolver
uniprot
Q920B5
resolver
uniprot_entry
Q3UP55_MOUSE
resolver
uniprot_entry
VPP4_MOUSE
resolver
uniprot_sec
Q8CJ79
resolver
uniprot_sec
Q920B5
resolver
amino_acid_sequence
MASVFRSEEMCLSQVFLQVEAAYCCVAELGELGLVQFKDLNANVNSFQRKFVNEVRRCESLERILRFLEDEMQNEILIQVPEKDAETPLPREMITLETTLEKLEGELQEANQSHQALKKSFLELTELKYLLKKTQDFFETETNLGEDFFVEDTSGLLELRTIPAFMTGKLGFTAGVINRERMASFERLLWRVCRGNVYLKFSEMDTLLEDPVTKEEIKKNIFIIFYQGEQLRLKIKKICDGFRATIYPCPEHAAERREMLTSVNVRLEDLITVITQTESHRQRLLQEAAANWHSWVIKVQKMKAVYHVLNMCNIDVTQQCIIAEIWFPVADTRHIKKALEQGMELSGSSMIPIMTEVETKTDPPTFNRTNKFTAGFQNIVDAYGVGSYREINPAPYTIITFPFLFAVMFGDCGHGMVMLMAALWMVLNERHLLAQKSTNEMWNIFFNGRYLILLMGIFSIYTGLIYNDCFSKSFNIFGSSWSVQPMFRNGTWNTHIVENSPYLQLDPAIPGVYSGNPYPFGIDPIWNLASNKLTFLNSYKMKMSVILGIAHMIFGVILSLFNHIYFRRTLNIILQFIPEMIFMLSLFGYLVFMIIFKWCRYDAHTSRKAPSILIHFIGMFLFDYDDSSNAPLYGHQQEVQTFFVIIALVSVPWMLLIKPFVLRAKHQKSQLQSFTIHEDAVEGDHSGHSSKKTAGAHGMKDGHEEEFNFGDIFVHQAIHTIEYCLGCISNTASYLRLWALSLAHAELSEVLWTMVMSIGLRLQGWAGLVGVFIIFAVFAVLTVAILLVMEGLSAFLHALRLHWVEFQNKFYEGAGSKFSPFSFKHVLEGTAEE
uniprot
proteins
function
FUNCTION: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Involved in normal vectorial acid transport into the urine by the kidney (By similarity). {ECO:0000250|UniProtKB:Q29466, ECO:0000250|UniProtKB:Q93050, ECO:0000250|UniProtKB:Q9HBG4}.
uniprot
proteins
mass_dalton
95605
uniprot
proteins
protein_family
V-ATPase 116 kDa subunit family
uniprot
proteins
pubmed
11495928
uniprot
proteins
pubmed
11498539
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
833
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:11495928, ECO:0000269|PubMed:11498539}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:11495928, ECO:0000269|PubMed:11498539}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the apical surface of alpha-intercalated cells in the cortical collecting ducts of the distal nephron (PubMed:11495928, PubMed:11498539). Localizes to the basolateral surface of beta-intercalated cells in the cortical collecting ducts of the distal nephron (PubMed:11495928, PubMed:11498539). {ECO:0000269|PubMed:11495928, ECO:0000269|PubMed:11498539}.
uniprot
proteins
transmembrane_region
TRANSMEM 391..409; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 412..428; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 444..473; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 539..558; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 577..597; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 643..662; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 721..745; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 767..805; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins