TEAD2
entrez
8463
canonical
uniprot
Q15562
canonical
ensembl
ENSG00000074219
resolver
ensp
ENSP00000310701
resolver
ensp
ENSP00000437928
resolver
ensp
ENSP00000469640
resolver
ensp
ENSP00000469672
resolver
ensp
ENSP00000472109
resolver
ensp
ENSP00000559978
resolver
ensp
ENSP00000559979
resolver
ensp
ENSP00000559981
resolver
ensp
ENSP00000559982
resolver
ensp
ENSP00000559985
resolver
ensp
ENSP00000559986
resolver
ensp
ENSP00000559987
resolver
ensp
ENSP00000559988
resolver
ensp
ENSP00000559989
resolver
ensp
ENSP00000559990
resolver
ensp
ENSP00000559992
resolver
ensp
ENSP00000559993
resolver
ensp
ENSP00000559994
resolver
ensp
ENSP00000559999
resolver
ensp
ENSP00000560002
resolver
ensp
ENSP00000560003
resolver
ensp
ENSP00000560004
resolver
ensp
ENSP00000560005
resolver
ensp
ENSP00000607255
resolver
ensp
ENSP00000607261
resolver
ensp
ENSP00000607262
resolver
ensp
ENSP00000607285
resolver
ensp
ENSP00000607295
resolver
ensp
ENSP00000607298
resolver
ensp
ENSP00000607303
resolver
ensp
ENSP00000607307
resolver
ensp
ENSP00000662396
resolver
ensp
ENSP00000662401
resolver
ensp
ENSP00000662402
resolver
ensp
ENSP00000704665
resolver
ensp
ENSP00000704669
resolver
ensp
ENSP00000704670
resolver
ensp
ENSP00000742062
resolver
ensp
ENSP00000742073
resolver
genesymbol
TEAD2
resolver
genesymbol_syn
TEF4
resolver
hgnc
HGNC:11715
resolver
uniprot
B4DTJ6
resolver
uniprot
M0R1T9
resolver
uniprot
Q8NA25
resolver
uniprot
Q96IG3
resolver
uniprot_entry
TEAD2_HUMAN
resolver
uniprot_sec
B4DTJ6
resolver
uniprot_sec
M0R1T9
resolver
uniprot_sec
Q8NA25
resolver
uniprot_sec
Q96IG3
resolver
amino_acid_sequence
MGEPRAGAALDDGSGWTGSEEGSEEGTGGSEGAGGDGGPDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARRKSREIQSKLKDQVSKDKAFQTMATMSSAQLISAPSLQAKLGPTGPQASELFQFWSGGSGPPWNVPDVKPFSQTPFTLSLTPPSTDLPGYEPPQALSPLPPPTPSPPAWQARGLGTARLQLVEFSAFVEPPDAVDSYQRHLFVHISQHCPSPGAPPLESVDVRQIYDKFPEKKGGLRELYDRGPPHAFFLVKFWADLNWGPSGEEAGAGGSISSGGFYGVSSQYESLEHMTLTCSSKVCSFGKQVVEKVETERAQLEDGRFVYRLLRSPMCEYLVNFLHKLRQLPERYMMNSVLENFTILQVVTNRDTQELLLCTAYVFEVSTSERGAQHHIYRLVRD
uniprot
proteins
function
FUNCTION: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}.
uniprot
proteins
mass_dalton
49243
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18579750
uniprot
proteins
pubmed
19324877
uniprot
proteins
pubmed
8702974
uniprot
proteins
sequence_length
447
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins