Cd47
entrez
16423
canonical
uniprot
Q61735
canonical
ensembl
ENSMUSG00000055447
resolver
ensp
ENSMUSP00000099853
resolver
ensp
ENSMUSP00000155178
resolver
ensp
ENSMUSP00000155289
resolver
ensp
ENSMUSP00000155856
resolver
ensp
ENSMUSP00000305876
resolver
ensp
ENSMUSP00000328977
resolver
ensp
ENSMUSP00000328978
resolver
ensp
ENSMUSP00000328979
resolver
ensp
ENSMUSP00000358473
resolver
ensp
ENSMUSP00000364246
resolver
enst
ENSMUST00000229206
resolver
enst
ENSMUST00000230641
resolver
genesymbol
Cd47
resolver
uniprot
A0A2R8VK70
resolver
uniprot
A0A2R8W6P0
resolver
uniprot
Q3U967
resolver
uniprot
Q921Z2
resolver
uniprot_entry
A0A2R8VK70_MOUSE
resolver
uniprot_entry
A0A2R8W6P0_MOUSE
resolver
uniprot_entry
CD47_MOUSE
resolver
uniprot_entry
Q3U967_MOUSE
resolver
uniprot_sec
Q921Z2
resolver
amino_acid_sequence
MWPLAAALLLGSCCCGSAQLLFSNVNSIEFTSCNETVVIPCIVRNVEAQSTEEMFVKWKLNKSYIFIYDGNKNSTTTDQNFTSAKISVSDLINGIASLKMDKRDAMVGNYTCEVTELSREGKTVIELKNRTVSWFSPNEKILIVIFPILAILLFWGKFGILTLKYKSSHTNKRIILLLVAGLVLTVIVVVGAILLIPGEKPVKNASGLGLIVISTGILILLQYNVFMTAFGMTSFTIAILITQVLGYVLALVGLCLCIMACEPVHGPLLISGLGIIALAELLGLVYMKFVASNQRTIQPPRNR
uniprot
proteins
function
FUNCTION: Adhesive protein that mediates cell-to-cell interactions (By similarity). Acts as a receptor for thrombospondin THBS1 and as modulator of integrin signaling through the activation of heterotrimeric G proteins (By similarity). Involved in signal transduction, cardiovascular homeostasis, inflammation, apoptosis, angiogenesis, cellular self-renewal, and immunoregulation (PubMed:20610415, PubMed:23591719, PubMed:27742621). Plays a role in modulating pulmonary endothelin EDN1 signaling (PubMed:27742621). Modulates nitrous oxide (NO) signaling, in response to THBS1, hence playing a role as a pressor agent, supporting blood pressure (PubMed:20610415). Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells (By similarity). Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation (By similarity). Positively modulates FAS-dependent apoptosis in T-cells, perhaps by enhancing FAS clustering (PubMed:15917238). Plays a role in suppressing angiogenesis and may be involved in metabolic dysregulation during normal aging (PubMed:32679764). In response to THBS1, negatively modulates wound healing (PubMed:18156939). Inhibits stem cell self-renewal, in response to THBS1, probably by regulation of the stem cell transcription factors POU5F1/OCT4, SOX2, MYC/c-Myc and KLF4 (PubMed:23591719). May play a role in membrane transport and/or integrin dependent signal transduction (By similarity). May prevent premature elimination of red blood cells (PubMed:10856220). {ECO:0000250|UniProtKB:P97829, ECO:0000250|UniProtKB:Q08722, ECO:0000269|PubMed:10856220, ECO:0000269|PubMed:15917238, ECO:0000269|PubMed:18156939, ECO:0000269|PubMed:20610415, ECO:0000269|PubMed:23591719, ECO:0000269|PubMed:27742621, ECO:0000269|PubMed:32679764}.
uniprot
proteins
mass_dalton
33098
uniprot
proteins
pubmed
10856220
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15917238
uniprot
proteins
pubmed
18156939
uniprot
proteins
pubmed
20610415
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23591719
uniprot
proteins
pubmed
27742621
uniprot
proteins
pubmed
32679764
uniprot
proteins
pubmed
7691831
uniprot
proteins
pubmed
9504415
uniprot
proteins
sequence_length
303
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7691831}; Multi-pass membrane protein {ECO:0000269|PubMed:7691831}.
uniprot
proteins
transmembrane_region
TRANSMEM 141..161; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 174..194; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 207..227; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 239..259; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 267..287; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins