Cep63
entrez
28135
canonical
uniprot
Q3UPP8
canonical
ensembl
ENSMUSG00000032534
resolver
ensp
ENSMUSP00000091306
resolver
ensp
ENSMUSP00000125621
resolver
ensp
ENSMUSP00000149157
resolver
ensp
ENSMUSP00000214616
resolver
ensp
ENSMUSP00000214617
resolver
enst
ENSMUST00000093791
resolver
enst
ENSMUST00000216281
resolver
genesymbol
Cep63
resolver
genesymbol_syn
D9Mgc48e
resolver
uniprot
A0A1L1SQR3
resolver
uniprot
F8VPJ7
resolver
uniprot
Q80ZM0
resolver
uniprot
U5KVR9
resolver
uniprot_entry
A0A1L1SQR3_MOUSE
resolver
uniprot_entry
CEP63_MOUSE
resolver
uniprot_entry
F8VPJ7_MOUSE
resolver
uniprot_entry
U5KVR9_MOUSE
resolver
uniprot_sec
Q80ZM0
resolver
amino_acid_sequence
MEALLEGIQNRGHSGGFLTSCEAELQELMKQIDIMVAHKKSEWEGQTHALETCLDIRDRELKALRSQLDMKHKEVGILHQQIEEHEKTKQEMAMEYKEELLKLQEELSRLKRSYEKLQKKQLREFRGNTKSFREDRSEIERLTGKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLANRKQKLESVELSSQSEIQHLNSKLERAKDTICANELEIERLNIRVNDLMGTNMTILQDHRQKEEKLRESEKLLEALQEEQKELKASLQSQETFILEAKMQEKLQTTLKAVGTQQSVERPLEDCQKERKYSSPGQGVLDNVLSQLDFSHSSEELLQAEVTRLEGSLESVSATCKQLSQELMEKYEELKRMEGHNNEYRTEIKKLKEQILQADQTYSSALEGMKMEISQLTRELHQRDITIASAKCSSSDMEKQLKAEMQKAEEKAVEHKEILSQLESLKLENHRLSETVMKLELGLHEAKEISLADLQENYIEALNKLVSENQQLQKDLMSTKSELEHATNMCKKKDGEIFNPAHSRAAGFKNAELKPIHGQHRHDGIKTEQYKTGHHSPRGQTLDSIDPVARGPSPLSSHISPGSSTVSLPSNFLFEAHSLPSVLDINDVNFSDSLSDCMNDQEEFVSSGSLPTSPLGSIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTALV
uniprot
proteins
function
FUNCTION: Required for normal spindle assembly (PubMed:24240477). Plays a key role in mother-centriole-dependent centriole duplication; the function also seems to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (By similarity). Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned (By similarity). Also recruits CDK1 to centrosomes (By similarity). Plays a role in DNA damage response (By similarity). Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (By similarity). Promotes stabilization of FXR1 protein by inhibiting FXR1 ubiquitination (By similarity). {ECO:0000250|UniProtKB:Q96MT8, ECO:0000269|PubMed:24240477}.
uniprot
proteins
mass_dalton
80449
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated via 'Lys-48'-linked ubiquitin, leading to its degradation. Deubiquitinated by USP36, promoting its stabilization. {ECO:0000250|UniProtKB:Q96MT8}.
uniprot
proteins
protein_family
CEP63 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21983783
uniprot
proteins
pubmed
24240477
uniprot
proteins
sequence_length
700
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21983783}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:24240477}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000250|UniProtKB:Q96MT8}. Note=Colocalizes with CDK5RAP2, CEP152 and WDR62in a discrete ring around the proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles. {ECO:0000250|UniProtKB:Q96MT8, ECO:0000269|PubMed:21983783, ECO:0000269|PubMed:24240477}.
uniprot
proteins