ST14
entrez
6768
canonical
uniprot
Q9Y5Y6
canonical
ensembl
ENSG00000149418
resolver
ensp
ENSP00000278742
resolver
enst
ENST00000278742
resolver
genesymbol
ST14
resolver
genesymbol_syn
PRSS14
resolver
genesymbol_syn
SNC19
resolver
genesymbol_syn
TADG15
resolver
hgnc
HGNC:11344
resolver
uniprot
Q9BS01
resolver
uniprot
Q9H3S0
resolver
uniprot
Q9HB36
resolver
uniprot
Q9HCA3
resolver
uniprot_entry
ST14_HUMAN
resolver
uniprot_sec
Q9BS01
resolver
uniprot_sec
Q9H3S0
resolver
uniprot_sec
Q9HB36
resolver
uniprot_sec
Q9HCA3
resolver
amino_acid_sequence
MGSDRARKGGGGPKDFGAGLKYNSRHEKVNGLEEGVEFLPVNNVKKVEKHGPGRWVVLAAVLIGLLLVLLGIGFLVWHLQYRDVRVQKVFNGYMRITNENFVDAYENSNSTEFVSLASKVKDALKLLYSGVPFLGPYHKESAVTAFSEGSVIAYYWSEFSIPQHLVEEAERVMAEERVVMLPPRARSLKSFVVTSVVAFPTDSKTVQRTQDNSCSFGLHARGVELMRFTTPGFPDSPYPAHARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPHALVQLCGTYPPSYNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRMSSCGGRLRKAQGTFNSPYYPGHYPPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYVEINGEKYCGERSQFVVTSNSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPCPGQFTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLLPQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYTRLPLFRDWIKENTGV
uniprot
proteins
disease_involvement
DISEASE: Ichthyosis, congenital, autosomal recessive 11 (ARCI11) [MIM:602400]: A form of autosomal recessive congenital ichthyosis, a disorder of keratinization with abnormal differentiation and desquamation of the epidermis, resulting in abnormal skin scaling over the whole body. The main skin phenotypes are lamellar ichthyosis (LI) and non-bullous congenital ichthyosiform erythroderma (NCIE), although phenotypic overlap within the same patient or among patients from the same family can occur. Lamellar ichthyosis is a condition often associated with an embedment in a collodion-like membrane at birth; skin scales later develop, covering the entire body surface. Non-bullous congenital ichthyosiform erythroderma characterized by fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs. {ECO:0000269|PubMed:17273967, ECO:0000269|PubMed:18843291}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.4.21.109
uniprot
proteins
function
FUNCTION: Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site (PubMed:10373424). Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing (PubMed:18843291). Proteolytically cleaves and therefore activates TMPRSS13 (PubMed:28710277). {ECO:0000269|PubMed:10373424, ECO:0000269|PubMed:18843291, ECO:0000269|PubMed:28710277}.
uniprot
proteins
mass_dalton
94770
uniprot
proteins
mutagenesis
MUTAGEN 656; /note="H->A: Abolishes catalytic activity."; /evidence="ECO:0000269|PubMed:16407223"; MUTAGEN 711; /note="D->A: Abolishes catalytic activity."; /evidence="ECO:0000269|PubMed:16407223"; MUTAGEN 805; /note="S->A: Abolishes catalytic activity."; /evidence="ECO:0000269|PubMed:16407223
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
10373424
uniprot
proteins
pubmed
10373425
uniprot
proteins
pubmed
10500122
uniprot
proteins
pubmed
11696548
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16007225
uniprot
proteins
pubmed
16407223
uniprot
proteins
pubmed
17273967
uniprot
proteins
pubmed
18843291
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
28710277
uniprot
proteins
pubmed
33732248
uniprot
proteins
pubmed
36756125
uniprot
proteins
sequence_length
855
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 56..76; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins