SNX17
entrez
9784
canonical
uniprot
Q15036
canonical
ensembl
ENSG00000115234
resolver
ensp
ENSP00000233575
resolver
ensp
ENSP00000439208
resolver
ensp
ENSP00000571297
resolver
genesymbol
SNX17
resolver
genesymbol_syn
KIAA0064
resolver
hgnc
HGNC:14979
resolver
uniprot
B4DDM3
resolver
uniprot
B4DQ37
resolver
uniprot
B4DQM7
resolver
uniprot
B4DTB8
resolver
uniprot
Q53HN7
resolver
uniprot
Q6IAS3
resolver
uniprot_entry
B4DDM3_HUMAN
resolver
uniprot_entry
B4DQ37_HUMAN
resolver
uniprot_entry
B4DTB8_HUMAN
resolver
uniprot_entry
SNX17_HUMAN
resolver
uniprot_sec
B4DQM7
resolver
uniprot_sec
Q53HN7
resolver
uniprot_sec
Q6IAS3
resolver
amino_acid_sequence
MHFSIPETESRSGDSGGSAYVAYNIHVNGVLHCRVRYSQLLGLHEQLRKEYGANVLPAFPPKKLFSLTPAEVEQRREQLEKYMQAVRQDPLLGSSETFNSFLRRAQQETQQVPTEEVSLEVLLSNGQKVLVNVLTSDQTEDVLEAVAAKLDLPDDLIGYFSLFLVREKEDGAFSFVRKLQEFELPYVSVTSLRSQEYKIVLRKSYWDSAYDDDVMENRVGLNLLYAQTVSDIERGWILVTKEQHRQLKSLQEKVSKKEFLRLAQTLRHYGYLRFDACVADFPEKDCPVVVSAGNSELSLQLRLPGQQLREGSFRVTRMRCWRVTSSVPLPSGSTSSPGRGRGEVRLELAFEYLMSKDRLQWVTITSPQAIMMSICLQSMVDELMVKKSGGSIRKMLRRRVGGTLRRSDSQQAVKSPPLLESPDATRESMVKLSSKLSAVSLRGIGSPSTDASASDVHGNFAFEGIGDEDL
uniprot
proteins
function
FUNCTION: Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:15121882, PubMed:15769472, PubMed:39587083). Binds to NPxY sequences in the cytoplasmic tails of target cargos (PubMed:21512128). Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (PubMed:22492727, PubMed:28892079, PubMed:39587083). Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16712798, PubMed:19005208). Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) (PubMed:16712798). {ECO:0000269|PubMed:15121882, ECO:0000269|PubMed:15769472, ECO:0000269|PubMed:16712798, ECO:0000269|PubMed:19005208, ECO:0000269|PubMed:21512128, ECO:0000269|PubMed:22492727, ECO:0000269|PubMed:28892079}.
uniprot
proteins
mass_dalton
52901
uniprot
proteins
mutagenesis
MUTAGEN 62; /note="K->A: No association with endosomes."; /evidence="ECO:0000269|PubMed:14739284"; MUTAGEN 432; /note="L->A: No effect on interaction with CCDC22, CCDC93, VPS26C and VPS35L."; /evidence="ECO:0000269|PubMed:28892079"; MUTAGEN 433; /note="S->D: No effect on interaction with CCDC22, CCDC93, VPS26C and VPS35L."; /evidence="ECO:0000269|PubMed:28892079"; MUTAGEN 440; /note="S->D: No effect on interaction with CCDC22, CCDC93, VPS26C and VPS35L."; /evidence="ECO:0000269|PubMed:28892079"; MUTAGEN 464; /note="G->V: Slightly decreases interaction with CCDC22, CCDC93, VPS26C and VPS35L."; /evidence="ECO:0000269|PubMed:28892079"; MUTAGEN 467..470; /note="Missing: Strongly decreases interaction with CCDC22, CCDC93, VPS26C and VPS35L. No effect on endosomal location."; /evidence="ECO:0000269|PubMed:28892079"; MUTAGEN 469; /note="D->K: Slightly decreases interaction with CCDC22, CCDC93, VPS26C and VPS35L."; /evidence="ECO:0000269|PubMed:28892079"; MUTAGEN 470; /note="L->G: Strongly decreases interaction with CCDC22, CCDC93, VPS26C and VPS35L. No effect on endosomal location."; /evidence="ECO:0000269|PubMed:28892079"; MUTAGEN 470; /note="Missing: Abolishes interaction with the retriever complex."; /evidence="ECO:0000269|PubMed:39587083
uniprot
proteins
protein_family
Sorting nexin family
uniprot
proteins
pubmed
11237770
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14739284
uniprot
proteins
pubmed
15121882
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15769472
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16712798
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19005208
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21512128
uniprot
proteins
pubmed
22492727
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28892079
uniprot
proteins
pubmed
33436498
uniprot
proteins
pubmed
39587083
uniprot
proteins
pubmed
7584044
uniprot
proteins
sequence_length
470
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11237770, ECO:0000269|PubMed:21512128}. Early endosome {ECO:0000269|PubMed:14739284, ECO:0000269|PubMed:15121882, ECO:0000269|PubMed:15769472, ECO:0000269|PubMed:21512128, ECO:0000269|PubMed:28892079}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:11237770, ECO:0000269|PubMed:16712798}; Peripheral membrane protein {ECO:0000269|PubMed:11237770}; Cytoplasmic side {ECO:0000269|PubMed:11237770}.
uniprot
proteins