GRAMD1C
entrez
54762
canonical
uniprot
Q8IYS0
canonical
ensembl
ENSG00000178075
resolver
ensp
ENSP00000350881
resolver
ensp
ENSP00000408135
resolver
ensp
ENSP00000419132
resolver
ensp
ENSP00000540546
resolver
genesymbol
GRAMD1C
resolver
hgnc
HGNC:25252
resolver
uniprot
A8K9Y1
resolver
uniprot
A8KA99
resolver
uniprot
B3KUR5
resolver
uniprot
Q6AW94
resolver
uniprot
Q6UWN1
resolver
uniprot
Q8N6S0
resolver
uniprot
Q9UF46
resolver
uniprot_entry
ASTRC_HUMAN
resolver
uniprot_entry
B3KUR5_HUMAN
resolver
uniprot_sec
A8K9Y1
resolver
uniprot_sec
A8KA99
resolver
uniprot_sec
Q6AW94
resolver
uniprot_sec
Q6UWN1
resolver
uniprot_sec
Q8N6S0
resolver
uniprot_sec
Q9UF46
resolver
amino_acid_sequence
MEGAPTVRQVMNEGDSSLATDLQEDVEENPSPTVEENNVVVKKQGPNLHNWSGDWSFWISSSTYKDRNEEYRRQFTHLPDTERLIADYACALQRDILLQGRLYLSENWLCFYSNIFRWETTISIALKNITFMTKEKTARLIPNAIQIVTESEKFFFTSFGARDRSYLSIFRLWQNVLLDKSLTRQEFWQLLQQNYGTELGLNAEEMENLSLSIEDVQPRSPGRSSLDDSGERDEKLSKSISFTSESISRVSETESFDGNSSKGGLGKEESQNEKQTKKSLLPTLEKKLTRVPSKSLDLNKNEYLSLDKSSTSDSVDEENVPEKDLHGRLFINRIFHISADRMFELLFTSSRFMQKFASSRNIIDVVSTPWTAELGGDQLRTMTYTIVLNSPLTGKCTAATEKQTLYKESREARFYLVDSEVLTHDVPYHDYFYTVNRYCIIRSSKQKCRLRVSTDLKYRKQPWGLVKSLIEKNSWSSLEDYFKQLESDLLIEESVLNQAIEDPGKLTGLRRRRRTFNRTAETVPKLSSQHSSGDVGLGAKGDITGKKKEMENYNVTLIVVMSIFVLLLVLLNVTLFLKLSKIEHAAQSFYRLRLQEEKSLNLASDMVSRAETIQKNKDQAHRLKGVLRDSIVMLEQLKSSLIMLQKTFDLLNKNKTGMAVES
uniprot
proteins
function
FUNCTION: Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). {ECO:0000250|UniProtKB:Q8CI52}.
uniprot
proteins
mass_dalton
76035
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
662
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8CI52}; Single-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q8CI52}; Single-pass membrane protein {ECO:0000255}. Note=In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS). {ECO:0000250|UniProtKB:Q8CI52}.
uniprot
proteins
transmembrane_region
TRANSMEM 557..577; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins