SPX
entrez
80763
canonical
uniprot
Q9BT56
canonical
ensembl
ENSG00000134548
resolver
ensp
ENSP00000256969
resolver
enst
ENST00000256969
resolver
genesymbol
SPX
resolver
genesymbol_syn
C12orf39
resolver
hgnc
HGNC:28139
resolver
uniprot
B3KND6
resolver
uniprot_entry
SPXN_HUMAN
resolver
uniprot_sec
B3KND6
resolver
amino_acid_sequence
MKGLRSLAATTLALFLVFVFLGNSSCAPQRLLERRNWTPQAMLYLKGAQGRRFISDQSRRKDLSDRPLPERRSPNPQLLTIPEAATILLASLQKSPEDEEKNFDQTRFLEDSLLNW
uniprot
proteins
function
FUNCTION: Plays a role as a central modulator of cardiovascular and renal function and nociception. Also plays a role in energy metabolism and storage. Inhibits adrenocortical cell proliferation with minor stimulation on corticosteroid release (By similarity). {ECO:0000250}.; FUNCTION: [Spexin-1]: Acts as a ligand for galanin receptors GALR2 and GALR3 (PubMed:17284679, PubMed:24517231). Intracerebroventricular administration of the peptide induces an increase in arterial blood pressure, a decrease in both heart rate and renal excretion and delayed natriuresis. Intraventricular administration of the peptide induces antinociceptive activity. Also induces contraction of muscarinic-like stomach smooth muscles. Intraperitoneal administration of the peptide induces a reduction in food consumption and body weight. Inhibits long chain fatty acid uptake into adipocytes (By similarity). {ECO:0000250, ECO:0000269|PubMed:17284679, ECO:0000269|PubMed:24517231}.; FUNCTION: [Spexin-2]: Intracerebroventricular administration of the peptide induces a decrease in heart rate, but no change in arterial pressure, and an increase in urine flow rate. Intraventricular administration of the peptide induces antinociceptive activity (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
13302
uniprot
proteins
protein_family
Spexin family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17284679
uniprot
proteins
pubmed
19132080
uniprot
proteins
pubmed
19193193
uniprot
proteins
pubmed
22038051
uniprot
proteins
pubmed
23080164
uniprot
proteins
pubmed
24517231
uniprot
proteins
pubmed
24550067
uniprot
proteins
sequence_length
116
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted. Secreted, extracellular space. Cytoplasmic vesicle, secretory vesicle. Note=Secreted via the classical ER/Golgi-dependent pathway into the extracellular medium largely as a full-length protein without the signal peptide, and not as a hydrolyzed and amidated peptide (PubMed:17284679, PubMed:19193193). Localized extracellularly surrounding the villous trophoblastic cells. Detected in the serum.
uniprot
proteins