Slc9a3
entrez
24784
canonical
uniprot
P26433
canonical
ensembl
ENSRNOG00000015159
resolver
ensembl
ENSRNOG00055003268
resolver
ensembl
ENSRNOG00060024855
resolver
ensembl
ENSRNOG00065019340
resolver
ensp
ENSRNOP00000020711
resolver
ensp
ENSRNOP00000083053
resolver
ensp
ENSRNOP00055003770
resolver
ensp
ENSRNOP00060035640
resolver
ensp
ENSRNOP00065025972
resolver
enst
ENSRNOT00000020711
resolver
enst
ENSRNOT00000094251
resolver
enst
ENSRNOT00055005073
resolver
enst
ENSRNOT00060043066
resolver
enst
ENSRNOT00065032543
resolver
genesymbol
Slc9a3
resolver
genesymbol_syn
Nhe3
resolver
uniprot
A0A8I5ZZ59
resolver
uniprot
G3V7Y7
resolver
uniprot_entry
A0A8I5ZZ59_RAT
resolver
uniprot_entry
G3V7Y7_RAT
resolver
uniprot_entry
SL9A3_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Seems to switch between active and inactive modes in response to various stimuli (By similarity). Activated directly or indirectly by membrane phosphatidylinositol (PIs) (By similarity). Regulated by a variety of auxiliary proteins, which facilitate the maturation, cell surface expression and function of the transporter. Inhibited specifically by the drug tenapanor (By similarity). {ECO:0000250|UniProtKB:P26432, ECO:0000250|UniProtKB:P48764}.
uniprot
proteins
amino_acid_sequence
MWHPALGPGWKPLLALALALTSLRGVRGIEEEPNSGGSFQIVTFKWHHVQDPYIIALWILVASLAKIVFHLSHKVTSVVPESALLIVLGLVLGGIVWAADHIASFTLTPTLFFFYLLPPIVLDAGYFMPNRLFFGNLGTILLYAVIGTIWNAATTGLSLYGVFLSGLMGELKIGLLDFLLFGSLIAAVDPVAVLAVFEEVHVNEVLFIIVFGESLLNDAVTVVLYNVFESFVTLGGDAVTGVDCVKGIVSFFVVSLGGTLVGVIFAFLLSLVTRFTKHVRIIEPGFVFVISYLSYLTSEMLSLSAILAITFCGICCQKYVKANISEQSATTVRYTMKMLASGAETIIFMFLGISAVDPVIWTWNTAFVLLTLVFISVYRAIGVVLQTWILNRYRMVQLETIDQVVMSYGGLRGAVAYALVVLLDEKKVKEKNLFVSTTLIVVFFTVIFQGLTIKPLVQWLKVKRSEQREPKLNEKLHGRAFDHILSAIEDISGQIGHNYLRDKWSNFDRKFLSKVLMRRSAQKSRDRILNVFHELNLKDAISYVAEGERRGSLAFIRSPSTDNMVNVDFSTPRPSTVEASVSYFLRENVSAVCLDMQSLEQRRRSIRDTEDMVTHHTLQQYLYKPRQEYKHLYSRHELTPNEDEKQDKEIFHRTMRKRLESFKSAKLGINQNKKAAKLYKRERAQKRRNSSIPNGKLPMENLAHNFTIKEKDLELSEPEEATNYEEISGGIEFLASVTKDVASDSGAGIDNPVFSPDEDLDPSILSRVPPWLSPGETVVPSQRARVQIPNSPSNFRRLTPFRLSNKSVDSFLQADGPEEQLQPASPESTHM
uniprot
proteins
function
FUNCTION: Plasma membrane Na(+)/H(+) antiporter. Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, playing a key role in salt and fluid absorption and pH homeostasis (PubMed:8393860, PubMed:9442041). Major apical Na(+)/H(+) exchanger in kidney and intestine playing an important role in renal and intestine Na(+) absorption and blood pressure regulation (By similarity). {ECO:0000250|UniProtKB:P48764, ECO:0000269|PubMed:8393860, ECO:0000269|PubMed:9442041}.
uniprot
proteins
mass_dalton
93133
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PRKACA at Ser-552 and Ser-605, which inhibits activity (PubMed:9933588). Phosphorylation of Ser-605 is essential for cAMP-mediated inhibition of SLC9A3 (PubMed:9933588). Phosphorylation at Ser-661 by SGK1 is associated with increased abundance at the cell membrane (By similarity). Phosphorylation at Ser-716 by CSNK2A1 regulates SLC9A3 activity through the formation of multiple signaling complexes (By similarity). {ECO:0000250|UniProtKB:P26432, ECO:0000269|PubMed:9933588}.
uniprot
proteins
protein_family
Monovalent cation:p
uniprot
proteins
protein_family
roton antiporter 1 (CPA1) transporter (TC 2.A.36) family
uniprot
proteins
pubmed
12576672
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
1577762
uniprot
proteins
pubmed
16293618
uniprot
proteins
pubmed
20584908
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8393860
uniprot
proteins
pubmed
9442041
uniprot
proteins
pubmed
9933588
uniprot
proteins
sequence_length
831
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:20584908}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48764}. Cell membrane {ECO:0000250|UniProtKB:P48764}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48764}. Recycling endosome membrane {ECO:0000269|PubMed:9442041}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48764}. Early endosome membrane {ECO:0000250|UniProtKB:P48764}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48764}. Note=In intestinal epithelial cells, localizes to the ileal brush border. Angiotensin-2 enhances apical expression (By similarity). Translocates between intracellular compartments and the plasma membrane via a clathrin-mediated pathway (PubMed:9442041). {ECO:0000250|UniProtKB:Q28362, ECO:0000269|PubMed:9442041}.
uniprot
proteins
transmembrane_region
TRANSMEM 49..71; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P48764"; TRANSMEM 80..99; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P48764"; TRANSMEM 109..126; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P48764"; TRANSMEM 130..165; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P48764"; TRANSMEM 179..200; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P48764"; TRANSMEM 203..234; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P48764"; TRANSMEM 242..276; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P48764"; TRANSMEM 279..301; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P48764"; TRANSMEM 304..320; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:P48764"; TRANSMEM 328..356; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:P48764"; TRANSMEM 365..386; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:P48764"; TRANSMEM 400..423; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:P48764"; TRANSMEM 431..464; /note="Helical; Name=13"; /evidence="ECO:0000250|UniProtKB:P48764
uniprot
proteins