GLIPR1L1
entrez
256710
canonical
uniprot
Q6UWM5
canonical
ensembl
ENSG00000173401
resolver
ensp
ENSP00000310770
resolver
ensp
ENSP00000367967
resolver
genesymbol
GLIPR1L1
resolver
hgnc
HGNC:28392
resolver
uniprot
Q96L06
resolver
uniprot_entry
GPRL1_HUMAN
resolver
uniprot_sec
Q96L06
resolver
amino_acid_sequence
MALKNKFSCLWILGLCLVATTSSKIPSITDPHFIDNCIEAHNEWRGKVNPPAADMKYMIWDKGLAKMAKAWANQCKFEHNDCLDKSYKCYAAFEYVGENIWLGGIKSFTPRHAITAWYNETQFYDFDSLSCSRVCGHYTQLVWANSFYVGCAVAMCPNLGGASTAIFVCNYGPAGNFANMPPYVRGESCSLCSKEEKCVKNLCRTPQLIIPNQNPFLKPTGRAPQQTAFNPFSLGFLLLRIF
uniprot
proteins
function
FUNCTION: Required for optimal fertilization at the stage of sperm-oocyte fusion, plays a role in optimizing acrosome function, the translocation of IZUMO1 during the acrosome reaction and the fertilization process. Component of epididymosomes, one type of membranous microvesicules which mediate the transfer of lipids and proteins to spermatozoa plasma membrane during epididymal maturation. Also component of the CD9-positive microvesicules found in the cauda region. {ECO:0000250|UniProtKB:Q32LB5, ECO:0000250|UniProtKB:Q9DAG6}.
uniprot
proteins
mass_dalton
27151
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. N-glycosylation decreases during the transit in the caput. {ECO:0000250|UniProtKB:Q32LB5}.
uniprot
proteins
protein_family
CRISP family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16714093
uniprot
proteins
sequence_length
242
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q9DAG6}. Cell membrane {ECO:0000250|UniProtKB:Q9DAG6}; Lipid-anchor, GPI-anchor {ECO:0000255}; Extracellular side {ECO:0000250|UniProtKB:Q9DAG6}. Membrane raft {ECO:0000250|UniProtKB:Q32LB5}. Secreted {ECO:0000250|UniProtKB:Q9DAG6}. Note=Located in the connecting piece of elongated spermatids and sperm. Also located in the apical region of the sperm head after sperm capacitation (By similarity). Weakly attached to the cell membrane and later secreted into the extracellular space (By similarity). Located on sperm equatorial segment and neck (By similarity). Associated with epididymosomes from the caput and cauda epididymis (By similarity). {ECO:0000250|UniProtKB:Q32LB5, ECO:0000250|UniProtKB:Q9DAG6}.
uniprot
proteins