Ntmt2
entrez
240879
canonical
uniprot
B2RXM4
canonical
ensembl
ENSMUSG00000040113
resolver
ensp
ENSMUSP00000124211
resolver
enst
ENSMUST00000159679
resolver
genesymbol
Ntmt2
resolver
genesymbol_syn
Mettl11b
resolver
uniprot_entry
NTM1B_MOUSE
resolver
amino_acid_sequence
MAHLGAHFAFRSRWQKTDDELCRHSMSFILHKAIRNDFFQSYLYLLEKIPLVKLYALTSQVIDGEMQFYARAKLFYQEVPATEEGMMGNFIELSNPDIQASREFLRKFVGGPGRAGTGCALDCGSGIGRVSKHVLLPVFSSVELVDMMESFLLEAQSYLQVNEDKVESYHCYSLQEFTPHLGRYDVIWIQWVSGYLTDKDLLAFLSRCRDGLKENGVIILKDNVAREGCIFDLSDSSVTRDMDILRSLIRKSGLVVLGQEKQEGFPEQCVPVWMFALHSDRHS
uniprot
proteins
ec_number
2.1.1.299
uniprot
proteins
function
FUNCTION: Alpha N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. Predominantly functions as a mono-methyltransferase but is also able to di-/tri-methylate the GPKRIA peptide and di-methylate the PPKRIA peptide (in vitro). May activate NTMT1 by priming its substrates for trimethylation. {ECO:0000250|UniProtKB:Q5VVY1}.
uniprot
proteins
mass_dalton
32313
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
protein_family
NTM1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
283
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5VVY1}.
uniprot
proteins