EPHB1
entrez
2047
canonical
uniprot
P54762
canonical
ensembl
ENSG00000154928
resolver
ensp
ENSP00000381097
resolver
genesymbol
EPHB1
resolver
genesymbol_syn
ELK
resolver
genesymbol_syn
EPHT2
resolver
genesymbol_syn
HEK6
resolver
genesymbol_syn
NET
resolver
hgnc
HGNC:3392
resolver
uniprot
A8K593
resolver
uniprot
B3KTB2
resolver
uniprot
B5A969
resolver
uniprot
O43569
resolver
uniprot
O95142
resolver
uniprot
O95143
resolver
uniprot
Q0VG87
resolver
uniprot_entry
EPHB1_HUMAN
resolver
uniprot_sec
A8K593
resolver
uniprot_sec
B3KTB2
resolver
uniprot_sec
B5A969
resolver
uniprot_sec
O43569
resolver
uniprot_sec
O95142
resolver
uniprot_sec
O95143
resolver
uniprot_sec
Q0VG87
resolver
amino_acid_sequence
MALDYLLLLLLASAVAAMEETLMDTRTATAELGWTANPASGWEEVSGYDENLNTIRTYQVCNVFEPNQNNWLLTTFINRRGAHRIYTEMRFTVRDCSSLPNVPGSCKETFNLYYYETDSVIATKKSAFWSEAPYLKVDTIAADESFSQVDFGGRLMKVNTEVRSFGPLTRNGFYLAFQDYGACMSLLSVRVFFKKCPSIVQNFAVFPETMTGAESTSLVIARGTCIPNAEEVDVPIKLYCNGDGEWMVPIGRCTCKPGYEPENSVACKACPAGTFKASQEAEGCSHCPSNSRSPAEASPICTCRTGYYRADFDPPEVACTSVPSGPRNVISIVNETSIILEWHPPRETGGRDDVTYNIICKKCRADRRSCSRCDDNVEFVPRQLGLTECRVSISSLWAHTPYTFDIQAINGVSSKSPFPPQHVSVNITTNQAAPSTVPIMHQVSATMRSITLSWPQPEQPNGIILDYEIRYYEKEHNEFNSSMARSQTNTARIDGLRPGMVYVVQVRARTVAGYGKFSGKMCFQTLTDDDYKSELREQLPLIAGSAAAGVVFVVSLVAISIVCSRKRAYSKEAVYSDKLQHYSTGRGSPGMKIYIDPFTYEDPNEAVREFAKEIDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGKIPVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTLDKMIRNPASLKTVATITAVPSQPLLDRSIPDFTAFTTVDDWLSAIKMVQYRDSFLTAGFTSLQLVTQMTSEDLLRIGITLAGHQKKILNSIHSMRVQISQSPTAMA
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity). {ECO:0000250|UniProtKB:Q8CBF3, ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:12925710, ECO:0000269|PubMed:18034775, ECO:0000269|PubMed:9430661, ECO:0000269|PubMed:9499402}.
uniprot
proteins
mass_dalton
109885
uniprot
proteins
mutagenesis
MUTAGEN 594; /note="Y->F: Loss of interaction with NCK1."; /evidence="ECO:0000269|PubMed:9430661"; MUTAGEN 600; /note="Y->F: Loss of interaction with SHC1 and SRC."; /evidence="ECO:0000269|PubMed:12925710"; MUTAGEN 651; /note="K->R: Kinase-dead mutant. Unable to autophosphorylate, to interact with SH2 domain-containing interactors, to activate the MAPK/ERK and JUN signaling cascades. Not ubiquitinated by CBL."; /evidence="ECO:0000269|PubMed:18034775, ECO:0000269|PubMed:9430661"; MUTAGEN 778; /note="Y->F: Loss of interaction with SHC1."; /evidence="ECO:0000269|PubMed:12925710"; MUTAGEN 928; /note="Y->F: Disrupts binding with the GRB10 SH2 domain, providing evidence for phosphorylation. Disrupts interaction with GRB7 and ACP1."; /evidence="ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:8798570, ECO:0000269|PubMed:9499402
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Autophosphorylation is stimulated by the ligand EFNB1. Required for interaction with SH2 domain-containing interactors, for activation of the MAPK/ERK and JUN signaling cascades and for ubiquitination by CBL. {ECO:0000269|PubMed:12223469, ECO:0000269|PubMed:18034775, ECO:0000269|PubMed:8798570}.; PTM: Ubiquitinated; (EFNB1)ligand-induced poly- and/or multi-ubiquitination by CBL is regulated by SRC and leads to lysosomal degradation. {ECO:0000269|PubMed:18034775}.
uniprot
proteins
protein_family
Ephrin receptor subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
11713248
uniprot
proteins
pubmed
12223469
uniprot
proteins
pubmed
12925710
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18034775
uniprot
proteins
pubmed
18593464
uniprot
proteins
pubmed
8666391
uniprot
proteins
pubmed
8798570
uniprot
proteins
pubmed
9267020
uniprot
proteins
pubmed
9430661
uniprot
proteins
pubmed
9499402
uniprot
proteins
sequence_length
984
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18034775}; Single-pass type I membrane protein {ECO:0000269|PubMed:18034775}. Early endosome membrane {ECO:0000269|PubMed:18034775}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8CBF3}.
uniprot
proteins
transmembrane_region
TRANSMEM 541..563; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins