Kcne3
entrez
63883
canonical
uniprot
Q9JJV7
canonical
ensembl
ENSRNOG00000063050
resolver
ensembl
ENSRNOG00055027553
resolver
ensembl
ENSRNOG00060002858
resolver
ensembl
ENSRNOG00065024028
resolver
ensp
ENSRNOP00000098796
resolver
ensp
ENSRNOP00000102937
resolver
ensp
ENSRNOP00000110902
resolver
ensp
ENSRNOP00055039246
resolver
ensp
ENSRNOP00055039255
resolver
ensp
ENSRNOP00055039266
resolver
ensp
ENSRNOP00060003284
resolver
ensp
ENSRNOP00060003290
resolver
ensp
ENSRNOP00060003295
resolver
ensp
ENSRNOP00065033647
resolver
ensp
ENSRNOP00065033655
resolver
ensp
ENSRNOP00065033663
resolver
enst
ENSRNOT00000112289
resolver
enst
ENSRNOT00000140820
resolver
enst
ENSRNOT00000155651
resolver
enst
ENSRNOT00055047700
resolver
enst
ENSRNOT00055047710
resolver
enst
ENSRNOT00055047720
resolver
enst
ENSRNOT00060004610
resolver
enst
ENSRNOT00060004616
resolver
enst
ENSRNOT00060004622
resolver
enst
ENSRNOT00065041198
resolver
enst
ENSRNOT00065041206
resolver
enst
ENSRNOT00065041214
resolver
genesymbol
Kcne3
resolver
uniprot_entry
KCNE3_RAT
resolver
amino_acid_sequence
METSNGTETWYKSLHAVLKALNTTLHSHLLCRPGPGPGSGTGPDNQTEDHRASLPGRNDNSYMYILFVMFLFAVTVGSLILGYTRSRKVDKRSDPYHVYIKNRVSMI
uniprot
proteins
function
FUNCTION: Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE3 beta subunit modulates the gating kinetics and enhances stability of the channel complex (PubMed:12954870, PubMed:21911611). Alters the gating of the delayed rectifier Kv channel containing KCNB1 alpha subunit (PubMed:12954870). Associates with KCNC4/Kv3.4 alpha subunit to form the subthreshold Kv channel in skeletal muscle and to establish the resting membrane potential (RMP) in muscle cells (By similarity). Association with KCNQ1/KCLQT1 alpha subunit may form the intestinal cAMP-stimulated potassium channel involved in chloride secretion that produces a current with nearly instantaneous activation with a linear current-voltage relationship (PubMed:21911611). {ECO:0000250|UniProtKB:Q9Y6H6, ECO:0000269|PubMed:12954870, ECO:0000269|PubMed:21911611}.
uniprot
proteins
mass_dalton
12001
uniprot
proteins
protein_family
Potassium channel KCNE family
uniprot
proteins
pubmed
11220365
uniprot
proteins
pubmed
12954870
uniprot
proteins
pubmed
14679187
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21911611
uniprot
proteins
sequence_length
107
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12954870, ECO:0000269|PubMed:14679187}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:12954870}. Perikaryon {ECO:0000250|UniProtKB:Q9Y6H6}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9Y6H6}. Membrane raft {ECO:0000250|UniProtKB:Q9Y6H6}. Note=Colocalizes with KCNB1 at high-density somatodendritic clusters on the surface of hippocampal neurons. {ECO:0000250|UniProtKB:Q9Y6H6}.
uniprot
proteins
transmembrane_region
TRANSMEM 61..81; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9Y6H6
uniprot
proteins