Gpr88
entrez
64443
canonical
uniprot
Q9ESP4
canonical
ensembl
ENSRNOG00000026953
resolver
ensembl
ENSRNOG00055001077
resolver
ensembl
ENSRNOG00060000968
resolver
ensembl
ENSRNOG00065022222
resolver
ensp
ENSRNOP00000038233
resolver
ensp
ENSRNOP00000100418
resolver
ensp
ENSRNOP00000101034
resolver
ensp
ENSRNOP00000107555
resolver
ensp
ENSRNOP00000111062
resolver
ensp
ENSRNOP00000111907
resolver
ensp
ENSRNOP00055001381
resolver
ensp
ENSRNOP00055001388
resolver
ensp
ENSRNOP00060000566
resolver
ensp
ENSRNOP00060000568
resolver
ensp
ENSRNOP00065030611
resolver
enst
ENSRNOT00000037068
resolver
enst
ENSRNOT00000129009
resolver
enst
ENSRNOT00000141206
resolver
enst
ENSRNOT00000150135
resolver
enst
ENSRNOT00000154821
resolver
enst
ENSRNOT00000167227
resolver
enst
ENSRNOT00055001781
resolver
enst
ENSRNOT00055001788
resolver
enst
ENSRNOT00060001286
resolver
enst
ENSRNOT00060001288
resolver
enst
ENSRNOT00065037853
resolver
genesymbol
Gpr88
resolver
genesymbol_syn
Strg
resolver
uniprot_entry
GPR88_RAT
resolver
amino_acid_sequence
MTNSSSTSTSTTTGGSLLLLCEEEESWAGRRIPVSLLYSGLAIGGTLANGMVIYLVSSFRKLQTTSNAFIVNGCAADLSVCALWMPQEAVLGLLPAGSAEPPGDWDSGGGSYRLLRGGLLGLGLTVSLLSHCLVALNRYLLITRAPATYQVLYQRRHTAGMLALSWALALGLVLLLPPWAPKPGAEPPQVHYPALLAAGALLAQTALLLHCYLGIVRRVRVSVKRVSVLNFHLLHQLPGCAAAAAAFPAAPHAPGAGGAAHPAQPQPLPAALQPRRAQRRLSGLSVLLLCCVFLLATQPLVWVSLASGFSLPVPWGVQAASWLLCCALSALNPLLYTWRNEEFRRSVRSVLPGVGDAAAAAAAATAVPAMSQAQLGTRAAGQHW
uniprot
proteins
function
FUNCTION: Orphan G protein-coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing (PubMed:25155879). May play a role in the regulation of cognitive and motor function (By similarity). Couples with the heterotrimeric G protein complex of the G(i) subfamily, consisting of GNAI1, GNB1 and GNG2, thereby acting through a G(i)-mediated pathway (By similarity). Plays a role in the attenuation of D1 dopamine receptor (D1R)-mediated cAMP response in ciliated cells (By similarity). In non-ciliated cells, involved in the inhibition of the beta-2 adrenergic receptor (B2AR) response (By similarity). {ECO:0000250|UniProtKB:Q9EPB7, ECO:0000250|UniProtKB:Q9GZN0, ECO:0000269|PubMed:25155879}.
uniprot
proteins
mass_dalton
40200
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11056049
uniprot
proteins
pubmed
25155879
uniprot
proteins
pubmed
26918661
uniprot
proteins
sequence_length
384
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26918661}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q9GZN0}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:26918661}. Nucleus {ECO:0000269|PubMed:26918661}. Note=Localized to cilia in ciliated cells; whereas in non-ciliated cells, distributed throughout the cell membrane (By similarity). During cortical lamination, subcellular location shifts, on the day of birth, from expression at the plasma membrane and in the cytoplasm to the nuclei of neurons. This intranuclear localization remains throughout adulthood. {ECO:0000250|UniProtKB:Q9GZN0, ECO:0000269|PubMed:26918661}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..56; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 74..94; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 117..136; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 159..179; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 196..216; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 286..306; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 311..331; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins