CORO7
entrez
79585
canonical
uniprot
P57737
canonical
ensembl
ENSG00000103426
resolver
ensembl
ENSG00000262246
resolver
ensembl
ENSG00000278760
resolver
ensembl
ENSG00000282725
resolver
ensp
ENSP00000251166
resolver
ensp
ENSP00000440460
resolver
ensp
ENSP00000461702
resolver
genesymbol
CORO7
resolver
hgnc
HGNC:26161
resolver
uniprot
B4DFD6
resolver
uniprot
B4DL18
resolver
uniprot
I3L416
resolver
uniprot
Q17RK4
resolver
uniprot_entry
CORO7_HUMAN
resolver
uniprot_sec
B4DFD6
resolver
uniprot_sec
B4DL18
resolver
uniprot_sec
I3L416
resolver
uniprot_sec
Q17RK4
resolver
amino_acid_sequence
MNRFRVSKFRHTEARPPRRESWISDIRAGTAPSCRNHIKSSCSLIAFNSDRPGVLGIVPLQGQGEDKRRVAHLGCHSDLVTDLDFSPFDDFLLATGSADRTVKLWRLPGPGQALPSAPGVVLGPEDLPVEVLQFHPTSDGILVSAAGTTVKVWDAAKQQPLTELAAHGDLVQSAVWSRDGALVGTACKDKQLRIFDPRTKPRASQSTQAHENSRDSRLAWMGTWEHLVSTGFNQMREREVKLWDTRFFSSALASLTLDTSLGCLVPLLDPDSGLLVLAGKGERQLYCYEVVPQQPALSPVTQCVLESVLRGAALVPRQALAVMSCEVLRVLQLSDTAIVPIGYHVPRKAVEFHEDLFPDTAGCVPATDPHSWWAGDNQQVQKVSLNPACRPHPSFTSCLVPPAEPLPDTAQPAVMETPVGDADASEGFSSPPSSLTSPSTPSSLGPSLSSTSGIGTSPSLRSLQSLLGPSSKFRHAQGTVLHRDSHITNLKGLNLTTPGESDGFCANKLRVAVPLLSSGGQVAVLELRKPGRLPDTALPTLQNGAAVTDLAWDPFDPHRLAVAGEDARIRLWRVPAEGLEEVLTTPETVLTGHTEKICSLRFHPLAANVLASSSYDLTVRIWDLQAGADRLKLQGHQDQIFSLAWSPDGQQLATVCKDGRVRVYRPRSGPEPLQEGPGPKGGRGARIVWVCDGRCLLVSGFDSQSERQLLLYEAEALAGGPLAVLGLDVAPSTLLPSYDPDTGLVLLTGKGDTRVFLYELLPESPFFLECNSFTSPDPHKGLVLLPKTECDVREVELMRCLRLRQSSLEPVAFRLPRVRKEFFQDDVFPDTAVIWEPVLSAEAWLQGANGQPWLLSLQPPDMSPVSQAPREAPARRAPSSAQYLEEKSDQQKKEELLNAMVAKLGNREDPLPQDSFEGVDEDEWD
uniprot
proteins
function
FUNCTION: F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology. {ECO:0000269|PubMed:16905771, ECO:0000269|PubMed:24768539}.
uniprot
proteins
mass_dalton
100605
uniprot
proteins
mutagenesis
MUTAGEN 472; /note="K->R: Impaired ability to regulate the anterograde Golgi to endosome transport."; /evidence="ECO:0000269|PubMed:24768539"; MUTAGEN 680; /note="K->R: Does not affect ability to regulate the anterograde Golgi to endosome transport."; /evidence="ECO:0000269|PubMed:24768539
uniprot
proteins
post_translational_modification
PTM: The membrane-associated form is phosphorylated on tyrosine residues. {ECO:0000250}.; PTM: Ubiquitinated via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex: 'Lys-33'-linked ubiquitination promotes interaction with EPS15 and facilitates actin polymerization at the trans-Golgi network, thereby facilitating post-Golgi trafficking. Deubiquitinated by ZRANB1/TRABID. {ECO:0000269|PubMed:24768539}.
uniprot
proteins
protein_family
WD repeat coronin family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15327992
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
16905771
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21130766
uniprot
proteins
pubmed
24768539
uniprot
proteins
sequence_length
925
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Predominantly cytosolic. Detected on vesicle-like cytoplasmic structures and on the cis-Golgi. Not associated with actin filaments.
uniprot
proteins