FGFBP1
entrez
9982
canonical
uniprot
Q14512
canonical
ensembl
ENSG00000137440
resolver
ensp
ENSP00000371770
resolver
ensp
ENSP00000558747
resolver
ensp
ENSP00000558748
resolver
ensp
ENSP00000625116
resolver
enst
ENST00000382333
resolver
enst
ENST00000888688
resolver
enst
ENST00000888689
resolver
enst
ENST00000955057
resolver
genesymbol
FGFBP1
resolver
genesymbol_syn
FGFBP
resolver
genesymbol_syn
HBP17
resolver
hgnc
HGNC:19695
resolver
uniprot
A8K5J2
resolver
uniprot_entry
FGFP1_HUMAN
resolver
uniprot_sec
A8K5J2
resolver
amino_acid_sequence
MKICSLTLLSFLLLAAQVLLVEGKKKVKNGLHSKVVSEQKDTLGNTQIKQKSRPGNKGKFVTKDQANCRWAATEQEEGISLKVECTQLDHEFSCVFAGNPTSCLKLKDERVYWKQVARNLRSQKDICRYSKTAVKTRVCRKDFPESSLKLVSSTLFGNTKPRKEKTEMSPREHIKGKETTPSSLAVTQTMATKAPECVEDPDMANQRKTALEFCGETWSSLCTFFLSIVQDTSC
uniprot
proteins
function
FUNCTION: Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth. {ECO:0000269|PubMed:11509569, ECO:0000269|PubMed:15806171, ECO:0000269|PubMed:1885605, ECO:0000269|PubMed:9334727}.
uniprot
proteins
mass_dalton
26264
uniprot
proteins
mutagenesis
MUTAGEN 214; /note="C->A: Strongly reduces interaction with FGF2."; /evidence="ECO:0000269|PubMed:16257968
uniprot
proteins
protein_family
Fibroblast growth factor-binding protein family
uniprot
proteins
pubmed
11148217
uniprot
proteins
pubmed
11509569
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15806171
uniprot
proteins
pubmed
16257968
uniprot
proteins
pubmed
1885605
uniprot
proteins
pubmed
9334727
uniprot
proteins
sequence_length
234
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000269|PubMed:11148217, ECO:0000269|PubMed:15806171}. Cell membrane {ECO:0000269|PubMed:11148217, ECO:0000269|PubMed:15806171}; Peripheral membrane protein {ECO:0000269|PubMed:11148217, ECO:0000269|PubMed:15806171}. Note=Extracellular and plasma membrane-associated. Colocalizes with HSPG2 in the pericellular environment of squamous cell carcinomas. {ECO:0000269|PubMed:11148217}.
uniprot
proteins