Jazf1
entrez
231986
canonical
uniprot
Q80ZQ5
canonical
ensembl
ENSMUSG00000063568
resolver
ensp
ENSMUSP00000074129
resolver
genesymbol
Jazf1
resolver
uniprot
Q8BLQ8
resolver
uniprot
Q8BWN4
resolver
uniprot_entry
JAZF1_MOUSE
resolver
uniprot_sec
Q8BLQ8
resolver
uniprot_sec
Q8BWN4
resolver
amino_acid_sequence
MTGIAAASFFSNTCRFGGCGLHFPTLADLIEHIEDNHIDTDPRVLEKQELQQPTYVALSYINRFMTDAARREQESLKKKIQPKLSLTLSSSVSRGNVSTPPRHSSGSLTPPVTPPITPSSSFRSSTPTGSEYDEEEVDYEESDSDESWTTESAISSEAILSSMCMNGGEEKPFACPVPGCKKRYKNVNGIKYHAKNGHRTQIRVRKPFKCRCGKSYKTAQGLRHHTINFHPPVSAEMIRKMQQ
uniprot
proteins
function
FUNCTION: Acts as a transcriptional corepressor of orphan nuclear receptor NR2C2 (By similarity). Inhibits expression of the gluconeogenesis enzyme PCK2 through inhibition of NR2C2 activity (PubMed:24380856). Also involved in transcriptional activation of NAMPT by promoting expression of PPARA and PPARD (PubMed:24930994). Plays a role in lipid metabolism by suppressing lipogenesis, increasing lipolysis and decreasing lipid accumulation in adipose tissue (PubMed:24380856, PubMed:25614086). Plays a role in glucose homeostasis by improving glucose metabolism and insulin sensitivity (PubMed:24380856, PubMed:25614086). {ECO:0000250|UniProtKB:Q86VZ6, ECO:0000269|PubMed:24380856, ECO:0000269|PubMed:24930994, ECO:0000269|PubMed:25614086}.
uniprot
proteins
mass_dalton
27098
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24380856
uniprot
proteins
pubmed
24930994
uniprot
proteins
pubmed
25614086
uniprot
proteins
sequence_length
243
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q86VZ6}.
uniprot
proteins