Ilf3
entrez
16201
canonical
uniprot
Q9Z1X4
canonical
ensembl
ENSMUSG00000032178
resolver
ensp
ENSMUSP00000065770
resolver
ensp
ENSMUSP00000111074
resolver
ensp
ENSMUSP00000149483
resolver
ensp
ENSMUSP00000149786
resolver
ensp
ENSMUSP00000150280
resolver
ensp
ENSMUSP00000203380
resolver
ensp
ENSMUSP00000203382
resolver
ensp
ENSMUSP00000203385
resolver
ensp
ENSMUSP00000203395
resolver
ensp
ENSMUSP00000203401
resolver
ensp
ENSMUSP00000203406
resolver
ensp
ENSMUSP00000344242
resolver
ensp
ENSMUSP00000344243
resolver
ensp
ENSMUSP00000344257
resolver
enst
ENSMUST00000115414
resolver
enst
ENSMUST00000213518
resolver
genesymbol
Ilf3
resolver
uniprot
A0A1L1STE4
resolver
uniprot
F6UW19
resolver
uniprot
Q45VK5
resolver
uniprot
Q45VK6
resolver
uniprot
Q80VD5
resolver
uniprot
Q812A1
resolver
uniprot
Q8BP80
resolver
uniprot
Q8C2H8
resolver
uniprot
Q8K588
resolver
uniprot_entry
A0A1L1STE4_MOUSE
resolver
uniprot_entry
F6UW19_MOUSE
resolver
uniprot_entry
ILF3_MOUSE
resolver
uniprot_entry
Q45VK5_MOUSE
resolver
uniprot_entry
Q45VK6_MOUSE
resolver
uniprot_sec
Q80VD5
resolver
uniprot_sec
Q812A1
resolver
uniprot_sec
Q8BP80
resolver
uniprot_sec
Q8C2H8
resolver
uniprot_sec
Q8K588
resolver
amino_acid_sequence
MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGNSELSEAENMDTPPDDESKEGAGEQKAEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKPTTALLDKVADNLAIQLTTVTEDKYEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEMEKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRVPTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEATDAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIPPSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKADPPQAMNALMRLNQLKPGLQYKLISQTGPVHAPIFTMSVEVDGSNFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGEDSAEESDGKPAIVAPPPVVEAVSNPSSVFPSDATTEQGPILTKHGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDTPLALEANKKKRTPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNIRGRGRGGNIRGRGRGRGFGGANHGGGYMNAGAGYGSYGYSSNSATAGYSQFYSNGGHSGNAGGGGSGGGGGSSSYSSYYQGDSYNSPVPPKHAGKKPLHGGQQKASYSSGYQSHQGQQQPYNQSQYSSYGTPQGKQKGYGHGQGSYSSYSNSYNSPGGGGGSDYSYDSKFNYSGSGGRSGGNSYGSSGSSSYNTGSHGGYGTGSGGSSSYQGKQGGYSSQSNYSSPGSSQSYSGPASSYQSSQGGYSRNTEHSMNYQYR
uniprot
proteins
function
FUNCTION: RNA-binding protein that plays an essential role in the biogenesis of circular RNAs (circRNAs) which are produced by back-splicing circularization of pre-mRNAs. Within the nucleus, promotes circRNAs processing by stabilizing the regulatory elements residing in the flanking introns of the circularized exons. Plays thereby a role in the back-splicing of a subset of circRNAs. As a consequence, participates in a wide range of transcriptional and post-transcriptional processes. Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (By similarity). Upon viral infection, ILF3 accumulates in the cytoplasm and participates in the innate antiviral response. Mechanistically, ILF3 becomes phosphorylated and activated by the double-stranded RNA-activated protein kinase/PKR which releases ILF3 from cellular mature circRNAs. In turn, unbound ILF3 molecules are able to interact with and thus inhibit viral mRNAs. {ECO:0000250|UniProtKB:Q12906, ECO:0000269|PubMed:21123651}.
uniprot
proteins
mass_dalton
96021
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Thr-188 and Thr-315 by PKR in response to RNA viruses. This phosphorylation results in the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3 where it can bind to viral RNAs and impede viral replication. {ECO:0000269|PubMed:21123651}.; PTM: Methylated by protein arginine N-methyltransferase 1. {ECO:0000250|UniProtKB:Q12906}.
uniprot
proteins
pubmed
10337617
uniprot
proteins
pubmed
15364895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21123651
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7519613
uniprot
proteins
sequence_length
898
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q12906}. Cytoplasm {ECO:0000269|PubMed:21123651}. Nucleus {ECO:0000269|PubMed:21123651}. Note=Localizes in the cytoplasm in response to viral infection. The unphosphorylated form is retained in the nucleus by ILF2. Phosphorylation at Thr-188 and Thr-315 causes the dissociation of ILF2 from the ILF2-ILF3 complex resulting in a cytoplasmic sequestration of ILF3. Localized in cytoplasmic mRNP granules containing untranslated mRNAs. {ECO:0000269|PubMed:21123651}.
uniprot
proteins