Mbnl2
entrez
105559
canonical
uniprot
Q8C181
canonical
ensembl
ENSMUSG00000022139
resolver
ensp
ENSMUSP00000085763
resolver
ensp
ENSMUSP00000126186
resolver
ensp
ENSMUSP00000153973
resolver
ensp
ENSMUSP00000154559
resolver
ensp
ENSMUSP00000169953
resolver
ensp
ENSMUSP00000169954
resolver
ensp
ENSMUSP00000169958
resolver
ensp
ENSMUSP00000169959
resolver
ensp
ENSMUSP00000169987
resolver
ensp
ENSMUSP00000169991
resolver
enst
ENSMUST00000167459
resolver
genesymbol
Mbnl2
resolver
genesymbol_syn
Kiaa4072
resolver
uniprot
A0A2K6EDM5
resolver
uniprot
D0EX61
resolver
uniprot
Q3TPH4
resolver
uniprot
Q5DTQ0
resolver
uniprot
Q8BUD8
resolver
uniprot_entry
A0A2K6EDM5_MOUSE
resolver
uniprot_entry
D0EX61_MOUSE
resolver
uniprot_entry
MBNL2_MOUSE
resolver
uniprot_sec
Q3TPH4
resolver
uniprot_sec
Q5DTQ0
resolver
uniprot_sec
Q8BUD8
resolver
amino_acid_sequence
MALNVAPVRDTKWLTLEVCRQYQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGRCSRENCKYLHPPTHLKTQLEINGRNNLIQQKTAAAMLAQQMQFMFPGTPLHPVPTFPVGPTIGTNAAISFAPYLAPVTPGVGLVPTEVLPTTPVIVPGSPPVTVPGSTATQKLLRTDKLEVCREFQRGNCARGETDCRFAHPADSTMIDTNDNTVTVCMDYIKGRCMREKCKYFHPPAHLQAKIKAAQHQANQAAVAAQAAAAAATVMTQSTAKALKRPLEATVDLAFPPGALHPLPKRQALEKSNGASTVFNPSVLHYQQALTSAQLQQHTAFIPTVPMMHSATSATVSAATTPATSVPFAATATANQIILK
uniprot
proteins
function
FUNCTION: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Together with RNA binding proteins RBPMS and RBFOX2, activates vascular smooth muscle cells alternative splicing events (By similarity). Regulates NCOR2 alternative splicing (By similarity). Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM) (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:F2Z3T4}.
uniprot
proteins
mass_dalton
40156
uniprot
proteins
protein_family
Muscleblind family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5VZF2}. Cytoplasm {ECO:0000250|UniProtKB:Q5VZF2}. Note=Greater concentration in the nucleus. Expressed in or near large cytoplasmic adhesion plaques. Location in the cytoplasm is microtubule-dependent. {ECO:0000250|UniProtKB:Q5VZF2}.
uniprot
proteins