Olr1
entrez
108078
canonical
uniprot
Q9EQ09
canonical
ensembl
ENSMUSG00000030162
resolver
ensp
ENSMUSP00000032265
resolver
ensp
ENSMUSP00000138228
resolver
ensp
ENSMUSP00000138588
resolver
enst
ENSMUST00000032265
resolver
enst
ENSMUST00000182784
resolver
enst
ENSMUST00000183258
resolver
genesymbol
Olr1
resolver
genesymbol_syn
Lox1
resolver
uniprot
G4WK09
resolver
uniprot
G4WK10
resolver
uniprot
Q3U3M1
resolver
uniprot
S4R1H8
resolver
uniprot
S4R2C3
resolver
uniprot_entry
G4WK09_MOUSE
resolver
uniprot_entry
G4WK10_MOUSE
resolver
uniprot_entry
OLR1_MOUSE
resolver
uniprot_entry
S4R1H8_MOUSE
resolver
uniprot_entry
S4R2C3_MOUSE
resolver
uniprot_sec
Q3U3M1
resolver
amino_acid_sequence
MTFDDKMKPANDEPDQKSCGKKPKGLHLLSSPWWFPAAMTLVILCLVLSVTLIVQWTQLRQVSDLLKQYQANLTQQDRILEGQMLAQQKAENTSQESKKELKGKIDTLTQKLNEKSKEQEELLQKNQNLQEALQRAANSSEESQRELKGKIDTITRKLDEKSKEQEELLQMIQNLQEALQRAANSSEESQRELKGKIDTLTLKLNEKSKEQEELLQKNQNLQEALQRAANFSGPCPQDWLWHKENCYLFHGPFSWEKNRQTCQSLGGQLLQINGADDLTFILQAISHTTSPFWIGLHRKKPGQPWLWENGTPLNFQFFKTRGVSLQLYSSGNCAYLQDGAVFAENCILIAFSICQKKTNHLQI
uniprot
proteins
function
FUNCTION: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
41643
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250}.
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
9588202
uniprot
proteins
sequence_length
363
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Membrane raft {ECO:0000250}. Secreted {ECO:0000250}. Note=A secreted form also exists. Localization to membrane rafts requires palmitoylation (By similarity). {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..54; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins