Fermt2
entrez
218952
canonical
uniprot
Q8CIB5
canonical
ensembl
ENSMUSG00000037712
resolver
ensp
ENSMUSP00000044554
resolver
ensp
ENSMUSP00000258210
resolver
ensp
ENSMUSP00000258211
resolver
ensp
ENSMUSP00000258212
resolver
ensp
ENSMUSP00000258213
resolver
ensp
ENSMUSP00000258218
resolver
ensp
ENSMUSP00000258223
resolver
enst
ENSMUST00000045905
resolver
genesymbol
Fermt2
resolver
genesymbol_syn
Plekhc1
resolver
uniprot
Q3TLE2
resolver
uniprot
Q8C542
resolver
uniprot
Q8K035
resolver
uniprot_entry
FERM2_MOUSE
resolver
uniprot_entry
Q3TLE2_MOUSE
resolver
uniprot_sec
Q8C542
resolver
uniprot_sec
Q8K035
resolver
amino_acid_sequence
MALDGIRMPDGCYADGTWELSVHVTDLNRDVTLRVTGEVHIGGVMLKLVEKLDVKKDWSDHALWWEKKRTWLLKTHWTLDKCGIQADAKLQFTPQHKLLRLQLPNMKYVKVKVNFSDRVFKAVSDICKTFNIRHPEELSLLKKPRDPTKKKKKKLDDQSEDEALELEGPLIMPGSGSIYSSPGLYSKTMTPTYDAHDGSPLSPTSAWFGDSALSEGNPGILAVSQPVTSPEILAKMFKPQALLDKAKTNQGWLDSSRSLMEQDVKENEALLLRFKYYSFFDLNPKYDAIRINQLYEQAKWALLLEEIECTEEEMMMFAALQYHINKLSIMTSENHLNNSDKEVDEVDAALSDLEITLEGGKTSTILGDITSIPELADYIKVFKPKKLTLKGYKQYWCTFKDTSISCYKSREESSGTPAHQLNLRGCEVTPDVNISGQKFNIKLLIPVAEGMNEIWLRCDNEKQYAHWMAACRLASKGKTMADSSYNLEVQNILSFLKMQHLNPDPQLIPDQITTDVNPECLVSPRYLKKYKSKQITARILEAHQNVAQMSLIEAKMRFIQAWQSLPEFGITHFIARFQGGKREELIGIAYNRLIRMDASTGDAIKTWRFSNMKQWNVNWEIKMVTVEFADEVRLSFICTEVDCKVVHEFIGGYIFLSTRAKDQNESLDEEMFYKLTSGWV
uniprot
proteins
function
FUNCTION: Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. {ECO:0000269|PubMed:18174465, ECO:0000269|PubMed:18483218, ECO:0000269|PubMed:21378273}.
uniprot
proteins
mass_dalton
77800
uniprot
proteins
mutagenesis
MUTAGEN 614..615; /note="QW->AA: Abolishes interaction with integrins ITGB1 and ITGB3."; /evidence="ECO:0000269|PubMed:18483218
uniprot
proteins
protein_family
Kindlin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18174465
uniprot
proteins
pubmed
18483218
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21378273
uniprot
proteins
pubmed
21768292
uniprot
proteins
sequence_length
680
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell projection, lamellipodium membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, myofibril, sarcomere, I band. Cell surface. Note=Colocalizes with actin stress fibers at cell-ECM focal adhesion sites. Colocalizes with ITGB3 at lamellipodia at the leading edge of spreading cells. Binds to membranes that contain phosphatidylinositides (By similarity). {ECO:0000250}.
uniprot
proteins