Tbc1d24
entrez
287110
canonical
uniprot
A0A0G2K5B0
canonical
ensembl
ENSRNOG00000052204
resolver
ensembl
ENSRNOG00055026846
resolver
ensembl
ENSRNOG00060010236
resolver
ensembl
ENSRNOG00065002278
resolver
ensembl
ENSRNOG00065010300
resolver
ensp
ENSRNOP00000071746
resolver
ensp
ENSRNOP00000073359
resolver
ensp
ENSRNOP00055038042
resolver
ensp
ENSRNOP00060013437
resolver
ensp
ENSRNOP00065002064
resolver
ensp
ENSRNOP00065012678
resolver
enst
ENSRNOT00000081995
resolver
enst
ENSRNOT00000084066
resolver
enst
ENSRNOT00055046377
resolver
enst
ENSRNOT00060017307
resolver
enst
ENSRNOT00065002998
resolver
enst
ENSRNOT00065016635
resolver
genesymbol
Tbc1d24
resolver
uniprot
D4A3Z3
resolver
uniprot_entry
D4A3Z3_RAT
resolver
uniprot_entry
TBC24_RAT
resolver
amino_acid_sequence
MDSPGYNCFVDKDKMDASIQDLGPKELNYTELQELKQLARQGYWAQSHALRGKVYQRLIRDIPCRTVTPDASVYSDIVGKIVGKHSSSSLPLPEFVDNTQVPTYCLNPRGEGAVRKILLCIANQFPDISFCPALPAVVALLLHYSIDEAECFEKACRILSCNDPGKKLIDQSFLAFESSCMTFGDLVNKYCQAAHKLMVAVSEDVLQVYSDWQRWLFGELPLNYFARVFDVFLVEGYKVLYRVALAILKFFHKVRAGQPLESDNVKQDIRMFVKDIAKTVSPEKLLEKAFAIRLFSRKEIQLLQMANEKALRQKGITVKQKSVSLSKRQFVHLAVHAENFRSEIVSVKEMRDIWSWIPERFALCQPLLLFSSLQHGYSLSRFYFQCEGHEPTLLLIKTTQKEVCGAYLSTDWSERNKFGGKLSFFGTGECFVFRLQPEVQRYEWVVIKHPELTKAASFKSSEAAANPCLISHSVSSDPADRLSPFLAARHFNLPSKTESMFMAGGNDCLIIGGGGGQALYIDGDLNRGRTGHCDTFNNQPLCSESFLIAAVEAWGFQDPDTQ
uniprot
proteins
function
FUNCTION: May act as a GTPase-activating protein for Rab family protein(s) (By similarity). Involved in neuronal projection development, probably through negative modulation of ARF6 function (By similarity). Required for the maintenance of postsynaptic neuron dendritic spines in the adult by suppressing ARF6 activity. Involved in the regulation of synaptic vesicle trafficking (By similarity). Promotes axonal outgrowth and membrane trafficking at the growth cone (PubMed:30858606). Positively regulates radial migration and morphological maturation of pyramidal neurons during cortical development by preventing ARF6 activation (PubMed:24469796). In one study, has been shown to inhibit the activity of the vacuolar-type ATPase (V-ATPase) by inducing disassembly of the V-ATPase complex (By similarity). In another study, has been shown to positively regulate V-ATPase assembly in neurons which promotes acidification of lysosomes and synaptic vesicles (By similarity). This supports neuronal autophagy and also regulates synaptic vesicle reacidification and the maintenance of the synaptic vesicle reserve pool (By similarity). Protects neuronal cells against oxidative stress (By similarity). Involved in the maintainenance of endosomal-mediated vesicle recycling and sustained exocytosis of hair cell ribbon synapses (By similarity). Facilitates formation of tubular recycling endosomes which promotes recycling of clathrin-independent endocytosis cargo proteins back to the plasma membrane (By similarity). {ECO:0000250|UniProtKB:Q3UUG6, ECO:0000250|UniProtKB:Q9ULP9, ECO:0000269|PubMed:24469796, ECO:0000269|PubMed:30858606}.
uniprot
proteins
mass_dalton
63410
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
24469796
uniprot
proteins
pubmed
30858606
uniprot
proteins
sequence_length
562
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9ULP9}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9ULP9}. Cytoplasm {ECO:0000250|UniProtKB:Q9ULP9}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9VIH7}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q3UUG6}. Presynapse {ECO:0000250|UniProtKB:Q3UUG6}. Postsynapse {ECO:0000250|UniProtKB:Q3UUG6}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q9ULP9}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q3UUG6}. Perikaryon {ECO:0000269|PubMed:30858606}. Cell projection, growth cone {ECO:0000269|PubMed:30858606}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q3UUG6}. Note=Mainly cytoplasmic with partial expression at the plasma membrane (By similarity). Associates with certain types of membrane phosphoinositides, preferentially those phosphorylated at the D5 position of the inositol ring such as phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidylinositol 3,4,5-trisphosphate (PIP3) (By similarity). In neurons, detected in the cell soma and along neurites (By similarity). Associated with clathrin-coated vesicles and synapses of hippocampal neurons (By similarity). {ECO:0000250|UniProtKB:Q3UUG6, ECO:0000250|UniProtKB:Q9ULP9, ECO:0000250|UniProtKB:Q9VIH7}.
uniprot
proteins