MAJIN
entrez
283129
canonical
uniprot
Q3KP22
canonical
ensembl
ENSG00000168070
resolver
ensp
ENSP00000301896
resolver
ensp
ENSP00000434568
resolver
ensp
ENSP00000659347
resolver
ensp
ENSP00000768379
resolver
ensp
ENSP00000768380
resolver
ensp
ENSP00000768381
resolver
ensp
ENSP00000768384
resolver
genesymbol
MAJIN
resolver
genesymbol_syn
C11orf85
resolver
hgnc
HGNC:27441
resolver
uniprot
A0A0P0YTB5
resolver
uniprot
B3KS99
resolver
uniprot
E9PPE5
resolver
uniprot_entry
A0A0P0YTB5_HUMAN
resolver
uniprot_entry
MAJIN_HUMAN
resolver
uniprot_sec
B3KS99
resolver
uniprot_sec
E9PPE5
resolver
amino_acid_sequence
MSLKPFTYPFPETRFLHAGPNVYKFKIRYGKSIRGEEIENKEVITQELEVPVEKKAVGAVMRKRKHMDEPSSPSRPGLDRAKIGTSSQGPSKKKPPVETRRNRERKTQQGLQETLASDITDVQKQDSEWGHSLPGRIVPPLQHNSPPPKERAATGFFGFLSSLFPFRYFFRKSSHS
uniprot
proteins
function
FUNCTION: Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane. {ECO:0000250|UniProtKB:Q9D992}.
uniprot
proteins
mass_dalton
20078
uniprot
proteins
protein_family
MAJIN family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
sequence_length
176
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000250|UniProtKB:Q9D992}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9D992}. Chromosome, telomere {ECO:0000250|UniProtKB:Q9D992}. Note=In leptotene spermatocytes, localizes to telomeres that localize to the nucleus inner membrane. {ECO:0000250|UniProtKB:Q9D992}.
uniprot
proteins
transmembrane_region
TRANSMEM 152..170; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins