Meikin
entrez
74847
canonical
uniprot
Q5F2C3
canonical
ensembl
ENSMUSG00000020332
resolver
ensp
ENSMUSP00000091745
resolver
genesymbol
Meikin
resolver
genesymbol_syn
4930404A10Rik
resolver
uniprot
Q3KNB2
resolver
uniprot
Q9D5P1
resolver
uniprot_entry
MEIKN_MOUSE
resolver
uniprot_entry
Q9D5P1_MOUSE
resolver
uniprot_sec
Q3KNB2
resolver
amino_acid_sequence
MDKIWHMGPRGDYTRKKRAGERLNLTPKPDLALPGRTEALPGLKGKGKEQGLRKITEKKELSRLTGSSSQRPSLLSVTGGEHLQENSPGQETPEEKTPPCETVTDTFEMDSLLSSTELVSGPAEQDDFSSCLPSCSNAELHTESTDERGSSFPSPELFRGSDCLDWEHPKLEDYMFYKNSTLLDTSKAVVIEKAPQFANLSAVLSSSSKNYEKRHRKIGMTLAAQHLSPEPKYASNLASVVDNAASEVVFAEKTGPPTTEKTQKKPENESEDSGPLVQTKLSSGHPDNKALCSPLSSALESTAVRYTLLPQPLEPVLKKGCILPDKQSKALLTSTPSSDIAEFVIDLSPVQNVSFEELFPNVSNYVNSSEVVPVSSLQESSSNEFSPNTSEICCIIRSSPGTRQMRRKDPAVKNRCSPPKDVPLDIIMKTNGRT
uniprot
proteins
function
FUNCTION: Key regulator of kinetochore function during meiosis I: required both for mono-orientation of kinetochores on sister chromosomes and protection of centromeric cohesin from separase-mediated cleavage. Acts by facilitating kinetochore mono-orientation during meiosis I, when kinetochores on sister chromosomes face the same direction and are thus captured and pulled by spindle fibers from the same pole. Also required to prevent cleavage of cohesin at centromeres during meiosis I, possibly by acting as a regulator of the shugoshin-dependent protection pathway. Acts in collaboration with PLK1: required for PLK1 enrichment to kinetochores. Not required during meiosis II or mitosis. {ECO:0000269|PubMed:25533956}.
uniprot
proteins
mass_dalton
47423
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
25533956
uniprot
proteins
sequence_length
434
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome, centromere {ECO:0000269|PubMed:25533956}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:25533956}. Note=Localizes at kinetochores in meiosis I but undetectable in meiosis II. {ECO:0000269|PubMed:25533956}.
uniprot
proteins