Coprs
entrez
66423
canonical
uniprot
Q9CQ13
canonical
ensembl
ENSMUSG00000031458
resolver
ensp
ENSMUSP00000033839
resolver
ensp
ENSMUSP00000281059
resolver
ensp
ENSMUSP00000281063
resolver
enst
ENSMUST00000033839
resolver
genesymbol
Coprs
resolver
genesymbol_syn
Copr5
resolver
uniprot_entry
COPRS_MOUSE
resolver
amino_acid_sequence
MDPQAATGRGPGERSSQEAPSAEAGFATADLSGRETETELAVDRLASGAQSIPADIPAHAEGPSSEEEGFAVEKEADGELYAWELSEGPSCPPMEQAADLFNEDWDLELKADQGNPYDADDIQGSISQEIKPWVCCAPQGDMIYDPSWHHPPPLIPHYSKMVFETGQFDDAED
uniprot
proteins
function
FUNCTION: Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression (By similarity). Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation. {ECO:0000250, ECO:0000269|PubMed:22193545}.
uniprot
proteins
mass_dalton
18666
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22193545
uniprot
proteins
sequence_length
173
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins