Brox
entrez
71678
canonical
uniprot
Q8K2Q7
canonical
ensembl
ENSMUSG00000046836
resolver
ensp
ENSMUSP00000061345
resolver
ensp
ENSMUSP00000132333
resolver
ensp
ENSMUSP00000289511
resolver
genesymbol
Brox
resolver
uniprot
Q8BWM8
resolver
uniprot
Q9DCT7
resolver
uniprot_entry
BROX_MOUSE
resolver
uniprot_sec
Q8BWM8
resolver
uniprot_sec
Q9DCT7
resolver
amino_acid_sequence
MTHWFHRNPLKATAPVSFNYYGMITGPPASKICNDLRSARTRLLELFTDLSCNPETMKNAADLYFSLLQGFINSVGDSTQESKLRYIQNFKWTDTLQGHVPSAQQDAVFELISMGFNVALWYTKYASRLAGKENITEDEAKEVHRSLKIAAGIFKHLKESHIPKLLTPAEKGRDLEARLIDAYIIQCQAEAQEVTIARAIELKHAPGLIAALAYDTASFYQKADHTLSSLEPAHSAKWRKYLHLKMCFYTAYAYCYHGQTLLASDKCGEAIRSLQEAEKLYAEAEALCKEYGETKGPGPTAKPSGHLFFRKLGSLVKNTLDKCQRENGFIYFQKIPTEAPQLELKANYGLVEPVPFEFPPMSAHWTPEALAAFDLTKRPKDDSVKPKPEEDVKPVKEPDIRPQKDTGCSVS
uniprot
proteins
function
FUNCTION: Nuclear envelope-associated factor that is involved in the nuclear envelope ruptures during interphase (NERDI) repair, where it is locally recruited by CHMP5 and reduces cytoskeletal stress through its action on SYN2 to help reseal the ruptured membrane. {ECO:0000250|UniProtKB:Q5VW32}.
uniprot
proteins
mass_dalton
46202
uniprot
proteins
post_translational_modification
PTM: Farnesylation is required for nuclear envelope localization. {ECO:0000250|UniProtKB:Q5VW32}.
uniprot
proteins
protein_family
BROX family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
411
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250|UniProtKB:Q5VW32}; Lipid-anchor {ECO:0000250|UniProtKB:Q5VW32}. Note=During nuclear envelope repair, localizes at rupture sites where it is recruited by the CHMP7/ESCRT-III axis. {ECO:0000250|UniProtKB:Q5VW32}.
uniprot
proteins