CALHM5
entrez
254228
canonical
uniprot
Q8N5C1
canonical
ensembl
ENSG00000178033
resolver
ensp
ENSP00000357588
resolver
enst
ENST00000368599
resolver
genesymbol
CALHM5
resolver
genesymbol_syn
C6orf188
resolver
genesymbol_syn
FAM26E
resolver
hgnc
HGNC:21568
resolver
uniprot
B2RDJ9
resolver
uniprot
B3KSR3
resolver
uniprot_entry
CAHM5_HUMAN
resolver
uniprot_sec
B2RDJ9
resolver
uniprot_sec
B3KSR3
resolver
amino_acid_sequence
MDAFQGILKFFLNQKTVIGYSFMALLTVGSERLFSVVAFKCPCSTENMTYGLVFLFAPAWVLLILGFFLNNRSWRLFTGCCVNPRKIFPRGHSCRFFYVLGQITLSSLVAPVMWLSVALLNGTFYECAMSGTRSSGLLELICKGKPKECWEELHKVSCGKTSMLPTVNEELKLSLQAQSQILGWCLICSASFFSLLTTCYARCRSKVSYLQLSFWKTYAQKEKEQLENTFLDYANKLSERNLKCFFENKRPDPFPMPTFAAWEAASELHSFHQSQQHYSTLHRVVDNGLQLSPEDDETTMVLVGTAHNM
uniprot
proteins
function
FUNCTION: May assemble to form large pore channels with gating and ion conductance likely regulated by membrane lipids. {ECO:0000269|PubMed:33298887}.
uniprot
proteins
mass_dalton
35170
uniprot
proteins
protein_family
CALHM family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
33298887
uniprot
proteins
sequence_length
309
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 16..37; /note="Helical; Name=S1"; /evidence="ECO:0000269|PubMed:33298887, ECO:0007744|PDB:7D60"; TRANSMEM 46..70; /note="Helical; Name=S2"; /evidence="ECO:0000269|PubMed:33298887, ECO:0007744|PDB:7D60"; TRANSMEM 100..129; /note="Helical; Name=S3"; /evidence="ECO:0000269|PubMed:33298887, ECO:0007744|PDB:7D60"; TRANSMEM 175..200; /note="Helical; Name=S4"; /evidence="ECO:0000269|PubMed:33298887, ECO:0007744|PDB:7D60
uniprot
proteins