HS3ST3A1
entrez
9955
canonical
uniprot
Q9Y663
canonical
ensembl
ENSG00000153976
resolver
ensp
ENSP00000284110
resolver
enst
ENST00000284110
resolver
genesymbol
HS3ST3A1
resolver
genesymbol_syn
3OST3A1
resolver
genesymbol_syn
HS3ST3A
resolver
hgnc
HGNC:5196
resolver
uniprot
A8K7N2
resolver
uniprot_entry
HS3SA_HUMAN
resolver
uniprot_sec
A8K7N2
resolver
amino_acid_sequence
MAPPGPASALSTSAEPLSRSIFRKFLLMLCSLLTSLYVFYCLAERCQTLSGPVVGLSGGGEEAGAPGGGVLAGGPRELAVWPAAAQRKRLLQLPQWRRRRPPAPRDDGEEAAWEEESPGLSGGPGGSGAGSTVAEAPPGTLALLLDEGSKQLPQAIIIGVKKGGTRALLEFLRVHPDVRAVGAEPHFFDRSYDKGLAWYRDLMPRTLDGQITMEKTPSYFVTREAPARISAMSKDTKLIVVVRDPVTRAISDYTQTLSKRPDIPTFESLTFKNRTAGLIDTSWSAIQIGIYAKHLEHWLRHFPIRQMLFVSGERLISDPAGELGRVQDFLGLKRIITDKHFYFNKTKGFPCLKKAEGSSRPHCLGKTKGRTHPEIDREVVRRLREFYRPFNLKFYQMTGHDFGWDG
uniprot
proteins
ec_number
2.8.2.30
uniprot
proteins
function
FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate (PubMed:10520990, PubMed:10608887, PubMed:15304505, PubMed:9988768). Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2 (PubMed:10520990, PubMed:15304505, PubMed:9988768). The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry (PubMed:10520990). Unlike HS3ST1/3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (PubMed:10520990). {ECO:0000269|PubMed:10520990, ECO:0000269|PubMed:10608887, ECO:0000269|PubMed:15304505, ECO:0000269|PubMed:9988768}.
uniprot
proteins
mass_dalton
44900
uniprot
proteins
mutagenesis
MUTAGEN 161; /note="K->A: 99.6% loss of enzymatic activity."; /evidence="ECO:0000269|PubMed:15304505"; MUTAGEN 162; /note="K->A: 99.6% loss of enzymatic activity; no HSV1 entry activity."; /evidence="ECO:0000269|PubMed:10520990, ECO:0000269|PubMed:15304505"; MUTAGEN 166; /note="R->E: 99.8% loss of enzymatic activity."; /evidence="ECO:0000269|PubMed:15304505"; MUTAGEN 170; /note="E->Q: 17% loss of enzymatic activity."; /evidence="ECO:0000269|PubMed:15304505"; MUTAGEN 173; /note="R->S: 44.1% loss of enzymatic activity."; /evidence="ECO:0000269|PubMed:15304505"; MUTAGEN 182; /note="G->A: No effect on enzymatic activity."; /evidence="ECO:0000269|PubMed:15304505"; MUTAGEN 184; /note="E->Q: 99.9% loss of enzymatic activity."; /evidence="ECO:0000269|PubMed:15304505"; MUTAGEN 186; /note="H->F: Abolishes enzymatic activity."; /evidence="ECO:0000269|PubMed:15304505"; MUTAGEN 189; /note="D->N: 99.1% loss of enzymatic activity."; /evidence="ECO:0000269|PubMed:15304505"; MUTAGEN 190; /note="R->E: 32% loss of enzymatic activity."; /evidence="ECO:0000269|PubMed:15304505"; MUTAGEN 194; /note="K->A: 99.5% loss of enzymatic activity."; /evidence="ECO:0000269|PubMed:15304505"; MUTAGEN 215; /note="K->A: 99.9% loss of enzymatic activity."; /evidence="ECO:0000269|PubMed:15304505"; MUTAGEN 218; /note="S->A: 23.3% loss of enzymatic activity."; /evidence="ECO:0000269|PubMed:15304505"; MUTAGEN 224; /note="E->Q: 47.6% loss of enzymatic activity."; /evidence="ECO:0000269|PubMed:15304505"; MUTAGEN 255; /note="Q->A: 99.6% loss of enzymatic activity."; /evidence="ECO:0000269|PubMed:15304505"; MUTAGEN 259; /note="K->A: 48.3% loss of enzymatic activity."; /evidence="ECO:0000269|PubMed:15304505"; MUTAGEN 288; /note="I->A: 65% loss of enzymatic activity."; /evidence="ECO:0000269|PubMed:15304505"; MUTAGEN 293; /note="K->A: 33.6% loss of enzymatic activity."; /evidence="ECO:0000269|PubMed:15304505"; MUTAGEN 362; /note="H->A: No effect on enzymatic activity."; /evidence="ECO:0000269|PubMed:15304505"; MUTAGEN 365; /note="G->A: 43% loss of enzymatic activity."; /evidence="ECO:0000269|PubMed:15304505"; MUTAGEN 366; /note="K->A: 99.8% loss of enzymatic activity."; /evidence="ECO:0000269|PubMed:15304505"; MUTAGEN 368; /note="K->A: 99.9% loss of enzymatic activity."; /evidence="ECO:0000269|PubMed:15304505"; MUTAGEN 370; /note="R->E: 99.2% loss of enzymatic activity."; /evidence="ECO:0000269|PubMed:15304505
uniprot
proteins
protein_family
Sulfotransferase 1 family
uniprot
proteins
pubmed
10520990
uniprot
proteins
pubmed
10608887
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15304505
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9988767
uniprot
proteins
pubmed
9988768
uniprot
proteins
sequence_length
406
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..43; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins