Nxnl1
entrez
234404
canonical
uniprot
Q8VC33
canonical
ensembl
ENSMUSG00000034829
resolver
ensp
ENSMUSP00000127094
resolver
enst
ENSMUST00000163659
resolver
genesymbol
Nxnl1
resolver
genesymbol_syn
Rdcvf
resolver
genesymbol_syn
Txnl6
resolver
uniprot
Q91W38
resolver
uniprot_entry
NXNL1_MOUSE
resolver
uniprot_sec
Q91W38
resolver
amino_acid_sequence
MASLFSGRILIRNNSDQDEVETEAELSRRLENRLVLLFFGAGACPQCQAFAPVLKDFFVRLTDEFYVLRAAQLALVYVSQDPTEEQQDLFLRDMPEKWLFLPFHDELRRDLGRQFSVRQLPAVVVLKPGGDVLTSDATEEIQRLGPACFANWQEAAELLDRSFLQPEDLDEPARRSITEPLRRRKYRVDRDVGRERGRNGRDSGDPQGDAGTRAELW
uniprot
proteins
function
FUNCTION: [Isoform 1]: Thioredoxin-like protein that protects retinal rod and cone photoreceptors against oxidative stress and photo-oxidative damage (PubMed:20139892, PubMed:25415434, PubMed:25596499, PubMed:27025156). Plays a role in the inhibition of TAU phosphorylation and protects TAU against oxidative stress in the retina (PubMed:19279044, PubMed:25596499). Acts as a reducing system for MSRA, facilitating the repair of oxidized proteins such as alpha-crystallin (CRYAA/CRYAB) and cytochrome c (CYCS) in the lens during oxidative stress conditions (By similarity). {ECO:0000250|UniProtKB:Q96CM4, ECO:0000269|PubMed:19279044, ECO:0000269|PubMed:20139892, ECO:0000269|PubMed:25415434, ECO:0000269|PubMed:25596499, ECO:0000269|PubMed:27025156}.; FUNCTION: [Isoform 2]: Plays an important role in retinal cone photoreceptor survival (PubMed:25957687, PubMed:25415434). In association with glucose transporter SLC16A1/GLUT1 and BSG, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687). May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods (PubMed:15220920). {ECO:0000269|PubMed:15220920, ECO:0000269|PubMed:25415434, ECO:0000269|PubMed:25957687}.
uniprot
proteins
mass_dalton
24912
uniprot
proteins
protein_family
Nucleoredoxin family
uniprot
proteins
pubmed
15220920
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19279044
uniprot
proteins
pubmed
19843539
uniprot
proteins
pubmed
20139892
uniprot
proteins
pubmed
25415434
uniprot
proteins
pubmed
25596499
uniprot
proteins
pubmed
25957687
uniprot
proteins
pubmed
27025156
uniprot
proteins
sequence_length
217
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000250|UniProtKB:Q96CM4}. Mitochondrion {ECO:0000250|UniProtKB:Q96CM4}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:15220920}.
uniprot
proteins