Arl3
entrez
56350
canonical
uniprot
Q9WUL7
canonical
ensembl
ENSMUSG00000025035
resolver
ensp
ENSMUSP00000026009
resolver
ensp
ENSMUSP00000158118
resolver
enst
ENSMUST00000026009
resolver
enst
ENSMUST00000236255
resolver
genesymbol
Arl3
resolver
uniprot
A0A494BAJ6
resolver
uniprot
Q543P7
resolver
uniprot_entry
A0A494BAJ6_MOUSE
resolver
uniprot_entry
ARL3_MOUSE
resolver
uniprot_entry
Q543P7_MOUSE
resolver
amino_acid_sequence
MGLLSILRKLKSAPDQEVRILLLGLDNAGKTTLLKQLASEDISHITPTQGFNIKSVQSQGFKLNVWDIGGQRKIRPYWRSYFENTDILIYVIDSADRKRFEETGQELTELLEEEKLSCVPVLIFANKQDLLTAAPASEIAEGLNLHTIRDRVWQIQSCSALTGEGVQDGMNWVCKNVNAKKK
uniprot
proteins
function
FUNCTION: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP) (PubMed:18376416). Required for normal cytokinesis and cilia signaling. Required for targeting proteins to the cilium, including myristoylated NPHP3 and prenylated INPP5E. Targets NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium (By similarity). Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms (PubMed:15979089). Required for PKD1:PKD2 complex targeting from the trans-Golgi network to the cilium (PubMed:25405894). {ECO:0000250|UniProtKB:P36405, ECO:0000269|PubMed:15979089, ECO:0000269|PubMed:18376416, ECO:0000269|PubMed:25405894}.
uniprot
proteins
mass_dalton
20487
uniprot
proteins
mutagenesis
MUTAGEN 31; /note="T->N: Inhibits interaction with PDE6D."; /evidence="ECO:0000269|PubMed:10518933"; MUTAGEN 49; /note="Q->L: Does not reduce the interaction with RP2."; /evidence="ECO:0000269|PubMed:18376416"; MUTAGEN 71; /note="Q->L: Does not inhibit interaction with PDE6D."; /evidence="ECO:0000269|PubMed:10518933, ECO:0000269|PubMed:18376416"; MUTAGEN 71; /note="Q->L: Inhibits RP2-dependent GTP-hydrolysis rate."; /evidence="ECO:0000269|PubMed:10518933, ECO:0000269|PubMed:18376416"; MUTAGEN 98; /note="K->Q: Does not reduce the interaction with RP2."; /evidence="ECO:0000269|PubMed:18376416"; MUTAGEN 164; /note="E->A: Reduces the interaction with RP2; when associated with A-168."; /evidence="ECO:0000269|PubMed:18376416"; MUTAGEN 168; /note="D->A: Reduces the interaction with RP2; when associated with A-164."; /evidence="ECO:0000269|PubMed:18376416
uniprot
proteins
protein_family
Arf family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10518933
uniprot
proteins
pubmed
11188688
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15979089
uniprot
proteins
pubmed
16565502
uniprot
proteins
pubmed
18376416
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25405894
uniprot
proteins
sequence_length
182
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, spindle. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm {ECO:0000250}. Cell projection, cilium {ECO:0000250|UniProtKB:P36405}. Note=Detected predominantly in the photoreceptor connecting cilium. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules (By similarity). Present on the mitotic spindle. {ECO:0000250}.
uniprot
proteins