Cacfd1
entrez
296599
canonical
uniprot
D4A9I3
canonical
ensembl
ENSRNOG00000005840
resolver
ensembl
ENSRNOG00055006081
resolver
ensembl
ENSRNOG00060028021
resolver
ensembl
ENSRNOG00065024003
resolver
ensp
ENSRNOP00000109944
resolver
ensp
ENSRNOP00055007622
resolver
ensp
ENSRNOP00060040592
resolver
ensp
ENSRNOP00065033642
resolver
enst
ENSRNOT00000155871
resolver
enst
ENSRNOT00055009864
resolver
enst
ENSRNOT00060048678
resolver
enst
ENSRNOT00065041193
resolver
genesymbol
Cacfd1
resolver
uniprot_entry
FLOWR_RAT
resolver
amino_acid_sequence
MSGSVAAGAAAGPVPPAQEEGMTWWYRWLCRLAGVLGAVSCAISGLFNCVTIHPLNIAAGVWMIMNAFILLLCEAPFCCQFVEFANTVAEKVDRLRSWQKAVFYCGMAIVPIVMSLTLTTLLGNAIAFATGVLYGLSALGKKGDAISYARIQQQRQQADEEKLAETFEGEL
uniprot
proteins
function
FUNCTION: Transmembrane protein which mediates synaptic endocytosis and fitness-based cell culling (By similarity). In response to different stimulus strengths, controls two major modes of synaptic vesicle (SV) retrieval in hippocampal neurons; Clathrin-mediated endocytosis (CME) in response to mild stimulation and activity-dependent bulk endocytosis (ADBE) in response to strong stimulation (PubMed:28414717). In cytotoxic T-lymphocytes (CTLs) facilitates calcium-dependent endocytosis of cytotoxic granules (CGs) at the immuno synapse (By similarity). Different isoforms work as fitness fingerprints in 'loser' and 'winner' cells and thereby mediate win/lose decisions as part of the cell competition process (By similarity). {ECO:0000250|UniProtKB:Q8BG21, ECO:0000250|UniProtKB:Q9UGQ2, ECO:0000269|PubMed:28414717}.
uniprot
proteins
mass_dalton
18414
uniprot
proteins
protein_family
Calcium channel flower family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22813738
uniprot
proteins
pubmed
28414717
uniprot
proteins
sequence_length
171
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000269|PubMed:22813738, ECO:0000269|PubMed:28414717}. Golgi apparatus {ECO:0000269|PubMed:28414717}. Vesicle {ECO:0000250|UniProtKB:Q8BG21}. Note=Enriched in synaptic vesicles at the presynaptic vesicles (PubMed:28414717). Detected in the Golgi apparatus of cultured hippocampal neurons (PubMed:28414717). In cytotoxic T-lymphocytes, localizes to intracellular vesicles that move to the immuno synapse (By similarity). {ECO:0000250|UniProtKB:Q8BG21, ECO:0000269|PubMed:28414717}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..52; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 57..77; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 102..122; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 125..141; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins