Tbx5
entrez
304514
canonical
uniprot
Q5I2P1
canonical
ensembl
ENSRNOG00000001399
resolver
ensp
ENSRNOP00000001893
resolver
enst
ENSRNOT00000001893
resolver
genesymbol
Tbx5
resolver
uniprot
G3V657
resolver
uniprot_entry
G3V657_RAT
resolver
uniprot_entry
TBX5_RAT
resolver
amino_acid_sequence
MADADEGFGLARTPLEPDSKDRSCDSKPESALGAPSKSPSSPQAAFTQQGMEGIKVFLHERELWLKFHEVGTEMIITKAGRQMFPSYKVKVTGLNPKTKYILLMDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNGFGSKNTAFCTHVFPETAFIAVTSYQNHKITQLKIENNPFAKGFRGSDDLELHRMSRMRSKEYPVVPRSTVRHKVANHSPFSSETRALSTSSNLGSQYQCENGVSGPSQDLLPPPNPYPLAQEHSQIYHCTKRKDEECSSTEHPYKKPYMETSPSEEDTFYRSGYPQQQGLSTSYRTESAQRQACMYASSAPPSEPVPSLEDISCNTWPSMPSYSSCTVTTVQPMDRLPYQHFSAHFTSGPLVPRLAGMANHGSPQLGEGMFQHQTSVTHQPVVRQCGPQTGLQSPGSLQPPEFLYTHGVPRTLSPHQYHSVHGVGMVPEWSENS
uniprot
proteins
function
FUNCTION: DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation. Binds to the core DNA motif of NPPA promoter. {ECO:0000250|UniProtKB:Q99593}.
uniprot
proteins
mass_dalton
57745
uniprot
proteins
post_translational_modification
PTM: Acetylation at Lys-338 by KAT2A and KAT2B promotes nuclear retention. {ECO:0000250|UniProtKB:Q99593}.
uniprot
proteins
sequence_length
517
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q99593, ECO:0000255|PROSITE-ProRule:PRU00201}. Cytoplasm {ECO:0000250|UniProtKB:Q99593}. Note=Shuttles between the cytoplasm and the nucleus. Acetylation at Lys-338 promotes nuclear retention. {ECO:0000250|UniProtKB:Q99593}.
uniprot
proteins