DCP1A
entrez
55802
canonical
uniprot
Q9NPI6
canonical
ensembl
ENSG00000272886
resolver
ensp
ENSP00000476046
resolver
ensp
ENSP00000476386
resolver
ensp
ENSP00000588337
resolver
ensp
ENSP00000626972
resolver
genesymbol
DCP1A
resolver
genesymbol_syn
SMIF
resolver
hgnc
HGNC:18714
resolver
uniprot
B4DHN9
resolver
uniprot
U3KQM8
resolver
uniprot_entry
DCP1A_HUMAN
resolver
uniprot_sec
B4DHN9
resolver
uniprot_sec
U3KQM8
resolver
amino_acid_sequence
MEALSRAGQEMSLAALKQHDPYITSIADLTGQVALYTFCPKANQWEKTDIEGTLFVYRRSASPYHGFTIVNRLNMHNLVEPVNKDLEFQLHEPFLLYRNASLSIYSIWFYDKNDCHRIAKLMADVVEEETRRSQQAARDKQSPSQANGCSDHRPIDILEMLSRAKDEYERNQMGDSNISSPGLQPSTQLSNLGSTETLEEMPSGSQDKSAPSGHKHLTVEELFGTSLPKEQPAVVGLDSEEMERLPGDASQKEPNSFLPFPFEQLGGAPQSETLGVPSAAHHSVQPEITTPVLITPASITQSNEKHAPTYTIPLSPVLSPTLPAEAPTAQVPPSLPRNSTMMQAVKTTPRQRSPLLNQPVPELSHASLIANQSPFRAPLNVTNTAGTSLPSVDLLQKLRLTPQHDQIQTQPLGKGAMVASFSPAAGQLATPESFIEPPSKTAAARVAASASLSNMVLAPLQSMQQNQDPEVFVQPKVLSSAIPVAGAPLVTATTTAVSSVLLAPSVFQQTVTRSSDLERKASSPSPLTIGTPESQRKPSIILSKSQLQDTLIHLIKNDSSFLSTLHEVYLQVLTKNKDNHNL
uniprot
proteins
ec_number
3.6.1.62
uniprot
proteins
function
FUNCTION: Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay (PubMed:12417715). Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP (PubMed:12417715). Contributes to the transactivation of target genes after stimulation by TGFB1 (PubMed:11836524). Essential for embryonic development (PubMed:33813271). {ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:33813271}.
uniprot
proteins
mass_dalton
63278
uniprot
proteins
mutagenesis
MUTAGEN 20; /note="D->A: Lowers decapping activity."; /evidence="ECO:0000269|PubMed:12417715"; MUTAGEN 59; /note="R->A: Lowers decapping activity."; /evidence="ECO:0000269|PubMed:12417715
uniprot
proteins
protein_family
DCP1 family
uniprot
proteins
pubmed
11836524
uniprot
proteins
pubmed
12417715
uniprot
proteins
pubmed
12515382
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15687258
uniprot
proteins
pubmed
16364915
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19150429
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21876179
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25220460
uniprot
proteins
pubmed
27918561
uniprot
proteins
pubmed
30258011
uniprot
proteins
pubmed
33813271
uniprot
proteins
sequence_length
582
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:12417715, ECO:0000269|PubMed:12515382, ECO:0000269|PubMed:16364915}. Nucleus {ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:12417715}. Note=Co-localizes with NANOS3 in the processing bodies (By similarity). Predominantly cytoplasmic, in processing bodies (PB) (PubMed:16364915). Nuclear, after TGFB1 treatment. Translocation to the nucleus depends on interaction with SMAD4 (PubMed:11836524). {ECO:0000250|UniProtKB:Q91YD3, ECO:0000269|PubMed:11836524, ECO:0000269|PubMed:16364915}.
uniprot
proteins