Ctnnd1
entrez
12388
canonical
uniprot
P30999
canonical
ensembl
ENSMUSG00000034101
resolver
ensembl
ENSMUSG00000101645
resolver
ensp
ENSMUSP00000042543
resolver
ensp
ENSMUSP00000064518
resolver
ensp
ENSMUSP00000065252
resolver
ensp
ENSMUSP00000107299
resolver
ensp
ENSMUSP00000107307
resolver
ensp
ENSMUSP00000107313
resolver
ensp
ENSMUSP00000107314
resolver
ensp
ENSMUSP00000107320
resolver
ensp
ENSMUSP00000107321
resolver
ensp
ENSMUSP00000107322
resolver
ensp
ENSMUSP00000107323
resolver
ensp
ENSMUSP00000107324
resolver
ensp
ENSMUSP00000107325
resolver
ensp
ENSMUSP00000107326
resolver
ensp
ENSMUSP00000260461
resolver
ensp
ENSMUSP00000260463
resolver
ensp
ENSMUSP00000331933
resolver
enst
ENSMUST00000111670
resolver
enst
ENSMUST00000111678
resolver
enst
ENSMUST00000111692
resolver
enst
ENSMUST00000111693
resolver
enst
ENSMUST00000111694
resolver
enst
ENSMUST00000111695
resolver
enst
ENSMUST00000111696
resolver
genesymbol
Ctnnd1
resolver
genesymbol_syn
Catns
resolver
genesymbol_syn
Kiaa0384
resolver
uniprot
E9Q8Z5
resolver
uniprot
E9Q8Z6
resolver
uniprot
E9Q8Z8
resolver
uniprot
E9Q905
resolver
uniprot
E9Q986
resolver
uniprot
G3X9V2
resolver
uniprot
Q3TSU9
resolver
uniprot
Q80XQ4
resolver
uniprot
Q8CHF8
resolver
uniprot_entry
CTND1_MOUSE
resolver
uniprot_entry
E9Q8Z5_MOUSE
resolver
uniprot_entry
E9Q8Z6_MOUSE
resolver
uniprot_entry
E9Q8Z8_MOUSE
resolver
uniprot_entry
E9Q905_MOUSE
resolver
uniprot_entry
E9Q986_MOUSE
resolver
uniprot_entry
G3X9V2_MOUSE
resolver
uniprot_sec
Q3TSU9
resolver
uniprot_sec
Q80XQ4
resolver
uniprot_sec
Q8CHF8
resolver
amino_acid_sequence
MDDSEVESTASILASVKEQEAQFEKLTRALEEERRHVSAQLERVRVSPQDANSLMANGTLTRRHQNGRFVGDADLERQKFSDLKLNGPQDHNHLLYSTIPRMQEPGQIVETYTEEDPEGAMSVVSVETTDDGTTRRTETTVKKVVKTMTTRTVQPVPMGPDGLPVDASAVSNNYIQTLGRDFRKNGNGGPGPYVGQAGTATLPRNFHYPPDGYGRHYEDGYPGGSDNYGSLSRVTRIEERYRPSMEGYRAPSRQDVYGPQPQVRVGGSSVDLHRFHPEPYGLEDDQRSMGYDDLDYGMMSDYGTARRTGTPSDPRRRLRSYEDMIGEEVPPDQYYWAPLAQHERGSLASLDSLRKGMPPPSNWRQPELPEVIAMLGFRLDAVKSNAAAYLQHLCYRNDKVKTDVRKLKGIPILVGLLDHPKKEVHLGACGALKNISFGRDQDNKIAIKNCDGVPALVRLLRKARDMDLTEVITGTLWNLSSHDSIKMEIVDHALHALTDEVIIPHSGWEREPNEDCKPRHIEWESVLTNTAGCLRNVSSERSEARRKLRECDGLVDALIFIVQAEIGQKDSDSKLVENCVCLLRNLSYQVHREIPQAERYQEALPTVANSTGPHAASCFGAKKGKDEWFSRGKKPTEDPANDTVDFPKRTSPARGYELLFQPEVVRIYISLLKESKTPAILEASAGAIQNLCAGRWTYGRYIRSALRQEKALSAIAELLTSEHERVVKAASGALRNLAVDARNKELIGKHAIPNLVKNLPGGQQNSSWNFSEDTVVSILNTINEVIAENLEAAKKLRETQGIEKLVLINKSGNRSEKEVRAAALVLQTIWGYKELRKPLEKEGWKKSDFQVNLNNASRSQSSHSYDDSTLPLIDRNQKSDKKPDREEIPMSNMGSNTKSLDNNYSTLNERGDHNRTLDRSGDLGDMEPLKGAPLMQKI
uniprot
proteins
function
FUNCTION: Key regulator of cell-cell adhesion that associates with and regulates the cell adhesion properties of both C-, E- and N-cadherins, being critical for their surface stability (PubMed:33972531). Promotes localization and retention of DSG3 at cell-cell junctions, via its interaction with DSG3 (PubMed:18343367). Beside cell-cell adhesion, regulates gene transcription through several transcription factors including ZBTB33/Kaiso2 and GLIS2, and the activity of Rho family GTPases and downstream cytoskeletal dynamics. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. {ECO:0000250, ECO:0000269|PubMed:15138284, ECO:0000269|PubMed:15817151, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:18343367, ECO:0000269|PubMed:33972531}.
uniprot
proteins
mass_dalton
104925
uniprot
proteins
mutagenesis
MUTAGEN 622..623; /note="KK->AA: Abolishes nuclear localization."; /evidence="ECO:0000269|PubMed:15138284
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by FER and other protein-tyrosine kinases. Phosphorylated at Ser-288 by PAK5. Dephosphorylated by PTPRJ (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Beta-catenin family
uniprot
proteins
pubmed
10207085
uniprot
proteins
pubmed
12087177
uniprot
proteins
pubmed
12465718
uniprot
proteins
pubmed
1334250
uniprot
proteins
pubmed
15138284
uniprot
proteins
pubmed
15240885
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15817151
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17344476
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
18343367
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19267394
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23001562
uniprot
proteins
pubmed
27375112
uniprot
proteins
pubmed
33972531
uniprot
proteins
sequence_length
938
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, adherens junction {ECO:0000269|PubMed:19267394, ECO:0000269|PubMed:27375112, ECO:0000269|PubMed:33972531}. Cytoplasm {ECO:0000269|PubMed:15138284, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:27375112}. Nucleus {ECO:0000269|PubMed:15138284, ECO:0000269|PubMed:17344476}. Cell membrane {ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:19267394}. Cell junction {ECO:0000269|PubMed:18343367}. Note=Interaction with GLIS2 promotes nuclear translocation (PubMed:17344476). Detected at cell-cell contacts (By similarity). NANOS1 induces its translocation from sites of cell-cell contact to the cytoplasm (By similarity). CDH1 enhances cell membrane localization (By similarity). Localizes to cell-cell contacts as keratinocyte differentiation progresses (PubMed:27375112). {ECO:0000250|UniProtKB:O60716, ECO:0000269|PubMed:17344476, ECO:0000269|PubMed:27375112}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:15138284}.
uniprot
proteins