Dgkz
entrez
104418
canonical
uniprot
Q80UP3
canonical
ensembl
ENSMUSG00000040479
resolver
ensp
ENSMUSP00000028667
resolver
ensp
ENSMUSP00000106934
resolver
ensp
ENSMUSP00000106937
resolver
ensp
ENSMUSP00000159231
resolver
ensp
ENSMUSP00000193883
resolver
ensp
ENSMUSP00000193887
resolver
enst
ENSMUST00000028667
resolver
enst
ENSMUST00000099709
resolver
enst
ENSMUST00000111303
resolver
enst
ENSMUST00000239257
resolver
genesymbol
Dgkz
resolver
uniprot
A0A668KL90
resolver
uniprot
A2AHJ6
resolver
uniprot
A2AHJ7
resolver
uniprot
A2AHK0
resolver
uniprot_entry
A0A668KL90_MOUSE
resolver
uniprot_entry
A2AHJ7_MOUSE
resolver
uniprot_entry
A2AHK0_MOUSE
resolver
uniprot_entry
DGKZ_MOUSE
resolver
uniprot_sec
A2AHJ6
resolver
amino_acid_sequence
MEPRDPSPEGRSSDSESASASSSGSERDAGPEPDKAPRRLTKRRFPGLRLFGHRKAITKSGLQHLAPPPPTPGAPCGESEEQIQSTVDWSESAVYGEHIWFETNVSGDFCYVGEQHCVAKMLPKSAPRKKCAACKIVVHTQCIKQLEKINFRCKPSFRESGSRNVREPTFVRHHWVHRRRQDGKCRHCGKGFQQKFTFHSKEIVAISCSWCKQAYHSKVSCFMMQQIEEPCSLGVHAAVVIPPTWILRARRPQNTLKASKKKKRASFKRRSSKKGPEEGRWRPFIIRPTPSPLMKPLLVFVNPKSGGNQGAKIIQSFLWYLNPRQVFDLSQGGPREALEMYRKVHNLRILACGGDGTVGWILSTLDQLRLKPPPPVAILPLGTGNDLARTLNWGGGYTDEPVSKILSHVEEGNVVQLDRWDLRAEPNPEAGPEERDDGATDRLPLDVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGTAFSDFLMGSSKDLAKHIRVVCDGMDLTPKIQDLKPQCIVFLNIPRYCAGTMPWGHPGEHHDFEPQRHDDGYLEVIGFTMTSLAALQVGGHGERLTQCREVLLTTAKAIPVQVDGEPCKLSASRIRIALRNQATMVQKAKRRSTAPLHSDQQPVPEQLRIQVSRVSMHDYEALHYDKEQLKEASVPLGTVVVPGDSDLELCRAHIERLQREPDGAGAKSPMCHQLSSKWCFLDATTASRFYRIDRAQEHLNYVTEIAQDEIYILDPELLGASARPDLPTPTSPLPASPCSPTPGSMQGDTALPQGEELIEAAKRNDCCKLQELHRAGGDLMHRDQKSRTLLHHAVSTGSKEVVRYLLDHAPPEILDAVEENGETCLHQAAALGQRTICHYIVEAGASLMKTDLQGDTPRQRAEKAQDTELAAYLENRQHYQMIQREDQETAV
uniprot
proteins
ec_number
2.7.1.107
uniprot
proteins
ec_number
2.7.1.93
uniprot
proteins
function
FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:12883552). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:12883552). Also plays an important role in the biosynthesis of complex lipids (Probable). Does not exhibit an acyl chain-dependent substrate specificity among diacylglycerol species. Can also phosphorylate 1-alkyl-2-acylglycerol in vitro but less efficiently and with a preference for alkylacylglycerols containing an arachidonoyl group (By similarity). The biological processes it is involved in include T cell activation since it negatively regulates T-cell receptor signaling which is in part mediated by diacylglycerol (PubMed:12883552). By generating phosphatidic acid, stimulates PIP5KIA activity which regulates actin polymerization (By similarity). Through the same mechanism could also positively regulate insulin-induced translocation of SLC2A4 to the cell membrane (PubMed:27739494). Regulates RASGRP1 activity (By similarity). {ECO:0000250|UniProtKB:Q13574, ECO:0000269|PubMed:12883552, ECO:0000269|PubMed:27739494, ECO:0000305|PubMed:12883552}.
uniprot
proteins
mass_dalton
104031
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; glycerolipid metabolism. {ECO:0000305|PubMed:12883552}.
uniprot
proteins
protein_family
Eukaryotic diacylglycerol kinase family
uniprot
proteins
pubmed
12883552
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20023381
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27739494
uniprot
proteins
sequence_length
929
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20023381}. Cytoplasm, cytosol {ECO:0000305|PubMed:20023381}. Cell membrane {ECO:0000250|UniProtKB:Q13574}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q13574}.
uniprot
proteins