Twnk
entrez
226153
canonical
uniprot
Q8CIW5
canonical
ensembl
ENSMUSG00000025209
resolver
ensp
ENSMUSP00000026227
resolver
ensp
ENSMUSP00000157397
resolver
enst
ENSMUST00000236685
resolver
genesymbol
Twnk
resolver
genesymbol_syn
Peo1
resolver
uniprot
A0A494B8Y2
resolver
uniprot
Q3V303
resolver
uniprot
Q8K1Z1
resolver
uniprot_entry
A0A494B8Y2_MOUSE
resolver
uniprot_entry
PEO1_MOUSE
resolver
uniprot_entry
Q3V303_MOUSE
resolver
uniprot_sec
Q8K1Z1
resolver
amino_acid_sequence
MWLLLRRAYPLRILLPLRGEWVGRRGLPRSLAPGPPRRRYRKEALPALEMPVSPVTTTEIRQYLRAHGIPFQDGHSCLRAPSPFVVSSDIKNEKKDAPTSFCLFIDKTTGHFLCMTSLAEGSWEDLQASVEGRGDGAKEGVLLREGPEAEVREEVLRIWNRAIPLWELPDPEEAQLARVMFGLTKVTDDTLRRFSVRYLRSARSLVFPWFTPGSSGLRGLKLLGAEGQENGVQYVETTIPRPGVYHNLFGLPLISRRDTEVVVTSRELDSLALSQSTGLPTLSLPRGTVCLPPALLPYLEQFRRIVFWLGDDLRSWEAAKLFARKLNPKRCSLVRPGNQQPRPLEALNQGLSLPRILRTALPAWHKSIVSFRQLREEVLGELSNVEQAAGVRWSRFPDLNRLLKGHRKGELTVFTGPTGSGKTTFISEYALDLCTQGVNTLWGSFEISNVRLARVMLTQFAVTRLEEQLDKYEEWADRFEDLPLYFMTFHGQQSIRSVIDTMQHAVYVYDVCHVVIDNLQFMMGHEQLSSDRIAAQDYIVGAFRKFATDNSCHVTLVIHPRKEDDDKELQTASIFGSAKASQEADNVLILQDRKLVTGPGKRYLQVSKNRFDGDVGVFPLEFNKNSLTFSIPPKSKARLKKIKDDNGLVAKKSSSGKKGAAHQNPEICLGQDPSPAQPDTSKSSG
uniprot
proteins
ec_number
5.6.2.3
uniprot
proteins
function
FUNCTION: Mitochondrial helicase involved in mtDNA replication and repair (By similarity). Might have a role in mtDNA repair (By similarity). Has DNA strand separation activity needed to form a processive replication fork for leading strand synthesis which is catalyzed by the formation of a replisome complex with POLG and mtSDB (By similarity). Preferentially unwinds DNA substrates with pre-existing 5'-and 3'- single-stranded tails but is also active on a 5'- flap substrate (By similarity). Can dissociate the invading strand of immobile or mobile D-loop DNA structures irrespective of the single strand polarity of the third strand (By similarity). In addition to its DNA strand separation activity, also has DNA strand annealing, DNA strand-exchange and DNA branch migration activities (By similarity). {ECO:0000250|UniProtKB:Q96RR1}.
uniprot
proteins
mass_dalton
76993
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15509589
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
685
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250|UniProtKB:Q96RR1}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q96RR1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q96RR1}. Note=Colocalizes with mtDNA in mitochondrial nucleoids, a nucleoproteins complex consisting of a number of copies of proteins associated with mtDNA, probably involved in mtDNA maintenance and expression (By similarity). Associates with phospholipid membranes via electrostatic binding (By similarity). Preferentially associates with membranes enriched with cardiolipin, a lipid abundant in the mitochondrial inner membrane (By similarity). ATPase and helicase activity is enhanced by binding to lipid membranes (By similarity). {ECO:0000250|UniProtKB:Q96RR1, ECO:0000250|UniProtKB:Q9VL76}.
uniprot
proteins