IL2RA
entrez
3559
canonical
uniprot
P01589
canonical
ensembl
ENSG00000134460
resolver
ensp
ENSP00000369287
resolver
ensp
ENSP00000369293
resolver
ensp
ENSP00000402024
resolver
enst
ENST00000379954
resolver
enst
ENST00000379959
resolver
enst
ENST00000447847
resolver
genesymbol
IL2RA
resolver
hgnc
HGNC:6008
resolver
uniprot
H0Y5Z0
resolver
uniprot
Q5W005
resolver
uniprot
Q5W007
resolver
uniprot_entry
H0Y5Z0_HUMAN
resolver
uniprot_entry
IL2RA_HUMAN
resolver
uniprot_entry
Q5W005_HUMAN
resolver
uniprot_sec
Q5W007
resolver
amino_acid_sequence
MDSYLLMWGLLTFIMVPGCQAELCDDDPPEIPHATFKAMAYKEGTMLNCECKRGFRRIKSGSLYMLCTGNSSHSSWDNQCQCTSSATRNTTKQVTPQPEEQKERKTTEMQSPMQPVDQASLPGHCREPPPWENEATERIYHFVVGQMVYYQCVQGYRALHRGPAESVCKMTHGKTRWTQPQLICTGEMETSQFPGEEKPQASPEGRPESETSCLVTTTDFQIQTEMAATMETSIFTTEYQVAVAGCVFLLISVLLLSGLTWQRRQRKSRRTI
uniprot
proteins
disease_involvement
DISEASE: Type 1 diabetes mellitus 10 (T1D10) [MIM:601942]: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269|PubMed:17676041}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; DISEASE: Immunodeficiency 41 with lymphoproliferation and autoimmunity (IMD41) [MIM:606367]: A disorder of immune dysregulation characterized by recurrent viral, fungal, and bacterial infections, lymphadenopathy, and variable autoimmune features, such as autoimmune enteropathy and eczematous skin lesions. {ECO:0000269|PubMed:23416241, ECO:0000269|PubMed:24116927}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. {ECO:0000269|PubMed:23416241, ECO:0000269|PubMed:24116927}.
uniprot
proteins
mass_dalton
30819
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
16293754
uniprot
proteins
pubmed
16477002
uniprot
proteins
pubmed
17676041
uniprot
proteins
pubmed
23416241
uniprot
proteins
pubmed
24116927
uniprot
proteins
pubmed
2996141
uniprot
proteins
pubmed
2999698
uniprot
proteins
pubmed
3030566
uniprot
proteins
pubmed
3134887
uniprot
proteins
pubmed
6090948
uniprot
proteins
pubmed
6090949
uniprot
proteins
pubmed
7529123
uniprot
proteins
sequence_length
272
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 241..259; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins