Cdon
entrez
50938
canonical
uniprot
O35158
canonical
ensembl
ENSRNOG00000011789
resolver
ensp
ENSRNOP00000016247
resolver
ensp
ENSRNOP00000085481
resolver
enst
ENSRNOT00000016248
resolver
enst
ENSRNOT00000103041
resolver
genesymbol
Cdon
resolver
genesymbol_syn
Cdo
resolver
uniprot
A0A8I6A2E2
resolver
uniprot
G3V7K7
resolver
uniprot_entry
A0A8I6A2E2_RAT
resolver
uniprot_entry
CDON_RAT
resolver
uniprot_entry
G3V7K7_RAT
resolver
amino_acid_sequence
MHPDLGPLWKLLYVLVILCSSVSSDLATYFISEPLSAVQKLGRPVVLHCSAKPVTARISWLHNGKRLDRNTEQIKIHRGTLTILSLNPSLSGCYQCVANNSVGAVVSGPATVSADALADFDSSTMHVITAEKKNTGFIGCRVPESNPKAEVRYKIRGKWLMYSTGNYIILPSGNLQILNVSSKDKGSYKCAAYNPVTSELKVEPAGRKLLVSRPSSDGFHILHPALSQALAVLPHSPVTLECVVSGVPASQVYWLKDGQDCLSGSNWRRLYSHLATASIDPADSGNYSCVVGNNSSGDVKHVTYTVNVLEHASISKGLHDQKVSLGATVRFTCEVHGNPAPNRTWFHNAQPIRPSSRHLTEGSVLKITGVIMEDSGLYQCMADNGIGFMQSTGRLQIEQDSGQRPVIVTAPANVEVTDGDFVTLSCNATGEPVPVIHWYGRHGLITSHPSQVLRSKSRKSHLFRPGDLDPEPVYLIMSQAGSSSLSIQAVTREHAGKYTCEAVNKHGSTQSEAFLTVVPFETNTKAEPVTPSEASQNDERDPRDGSESGLLNLFPVKVHSGGVELPAEKNASVPDAPNILSPPQTHMPDTYTLVWRTGRDGGMPINAYFVKYRKLDDGSGAVGSWHTVRVPGSESELHLTELEPSSLYEVLMVARSAVGEGQPAMLTFRTSKEKMASSKNTQASFPPVGIPKRPVTSEASNSNFGVVLTDSSRHSGVPEAPDRPTISMASETSVYVTWIPRANGGSPITAFKVEYKRMKSSDWLVAAEDIPPSKLSVEVRSLEPGSIYKFRVIVINHYGESFRSSASRPYQVAGFPNRFSNRPITGPHIAYTEAVSDTQIMLKWTYIPSSNNNTPIQGFYIYYRPTDSDNDSDYKRDVVEGSKQWHTIGHLQPETSYDIKMQCFNEGGESEFSNVMICETKVKRVPGASEYPMKELSTPPSSSGNGGNVGPATSPARSSDMLYLIVGCVLGVMVLILLVFIALCLWKSRQQSAIQKYDPPGYLYQGSEINGQMVEYTTLSGTARINGSVHGGFLSKGSLSNGCSHLHHKGPNGVNGILNGTINGGLYSAHTSSLTRTCVEFEHPHHLVNGGAVYTAVPQMDPLECINCRNCRNNNRCFTKTNSPLPVVPVVASYPQDGLEMKPLGVMKFPVCPVSTVPDGGQIPEECLKDSVAPAPTQRTCRQDNTSDINSDSTEDTAEFNRGDSSGHSEAEDKVFSWSPLILSPVLEDCSEKTAWSPPGPPLDGLSVVLQQAQET
uniprot
proteins
function
FUNCTION: Together with BOC, forms a coreceptor required for sonic hedgehog (SHH) handoff to its patched receptor (PTCH1 or PTCH2), thereby allowing activation of the smoothened signaling pathway (PubMed:21802063). Binds to the dually lipid-modified Sonic hedgehog protein N-product (ShhN) downstream of SCUBE2 carrier and promotes its release to GAS1 (By similarity). ShhN is then directly transferred to patched receptor by GAS1 (By similarity). May also mediate cell-cell interactions between muscle precursor cells, promoting differentiation of myogenic cells (By similarity). Required for response to NTN3 and activation of NFATC3 (By similarity). {ECO:0000250|UniProtKB:Q32MD9, ECO:0000269|PubMed:21802063}.
uniprot
proteins
mass_dalton
136204
uniprot
proteins
mutagenesis
MUTAGEN 686; /note="P->A: Fails to support induction of the Sonic hedgehog/SSH receptors PTCH1 and GLI1. The mutant protein retains very little residual activity even during overexpression and interacts with SHH, but does not interact with PTCH1, BOC, or GAS1."; /evidence="ECO:0000269|PubMed:21802063"; MUTAGEN 777; /note="V->E: Fails to support induction of the Sonic hedgehog/SSH receptors PTCH1 and GLI1. The mutant protein retains some residual activity during overexpression. The mutant protein interacts with SHH, but does not interact with PTCH1. The mutation protein has a shorted half-life compared to wild-type and may have an altered conformation resulting in destabilization."; /evidence="ECO:0000269|PubMed:21802063"; MUTAGEN 787; /note="I->A: Fails to support induction of the Sonic hedgehog/SSH receptors PTCH1 and GLI1. The mutant protein retains some residual activity during overexpression. The mutant protein interacts with SHH, but does not interact with GAS1."; /evidence="ECO:0000269|PubMed:21802063"; MUTAGEN 937; /note="S->R: Fails to support induction of the Sonic hedgehog/SSH receptors PTCH1 and GLI1. The mutant protein retains some residual activity during overexpression. The mutant protein interacts with SHH, but does not interact with PTCH1 or GAS1. The mutation protein has a shorted half-life compared to wild-type and may have an altered conformation resulting in destabilization."; /evidence="ECO:0000269|PubMed:21802063
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:9214393}.
uniprot
proteins
pubmed
21802063
uniprot
proteins
pubmed
9214393
uniprot
proteins
sequence_length
1256
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21802063, ECO:0000269|PubMed:9214393}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 964..984; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins