Slc1a2
entrez
29482
canonical
uniprot
P31596
canonical
ensembl
ENSRNOG00000005479
resolver
ensp
ENSRNOP00000094162
resolver
ensp
ENSRNOP00000100271
resolver
ensp
ENSRNOP00000112804
resolver
enst
ENSRNOT00000118194
resolver
enst
ENSRNOT00000155256
resolver
genesymbol
Slc1a2
resolver
genesymbol_syn
Eaat2
resolver
genesymbol_syn
Glt1
resolver
uniprot
A0ABK0KYQ9
resolver
uniprot
A0ABK0M9V6
resolver
uniprot
Q8K5B5
resolver
uniprot
Q8R4I5
resolver
uniprot_entry
A0ABK0KYQ9_RAT
resolver
uniprot_entry
A0ABK0M9V6_RAT
resolver
uniprot_entry
EAA2_RAT
resolver
uniprot_entry
Q8K5B5_RAT
resolver
uniprot_entry
Q8R4I5_RAT
resolver
amino_acid_sequence
MASTEGANNMPKQVEVRMHDSHLSSEEPKHRNLGMRMCDKLGKNLLLSLTVFGVILGAVCGGLLRLAAPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRAMVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLDLIRNLFPENLVQACFQQIQTVTKKVLVAPPSEEANTTKAVISLLNETMNEAPEETKIVIKKGLEFKDGMNVLGLIGFFIAFGIAMGKMGEQAKLMVEFFNILNEIVMKLVIMIMWYSPLGIACLICGKIIAIKDLEVVARQLGMYMITVIVGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALGTASSAGTLPVTFRCLEDNLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVILDGGQIVTVSLTATLASIGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTSVNVVGDSFGAGIVYHLSKSELDTIDSQHRMHEDIEMTKTQSVYDDTKNHRESNSNQCVYAAHNSVVIDECKVTLAANGKSADCSVEEEPWKREK
uniprot
proteins
function
FUNCTION: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:1448170, PubMed:7913472). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:1448170). Mediates Cl(-) flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na(+) symport (By similarity). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity). {ECO:0000250|UniProtKB:P43004, ECO:0000250|UniProtKB:P43006, ECO:0000269|PubMed:1448170, ECO:0000269|PubMed:7913472}.
uniprot
proteins
mass_dalton
62106
uniprot
proteins
mutagenesis
MUTAGEN 298; /note="K->H,R: Normal transporter activity."; /evidence="ECO:0000269|PubMed:7913472"; MUTAGEN 298; /note="K->N,T: Reduced transporter activity."; /evidence="ECO:0000269|PubMed:7913472"; MUTAGEN 326; /note="H->N,T,K,R: No transporter activity."; /evidence="ECO:0000269|PubMed:7913472
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:P43006}.; PTM: Palmitoylation at Cys-38 is not required for correct subcellular localization, but is important for glutamate uptake activity. {ECO:0000250|UniProtKB:P43006}.
uniprot
proteins
protein_family
Dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family
uniprot
proteins
protein_family
SLC1A2 subfamily
uniprot
proteins
pubmed
11068035
uniprot
proteins
pubmed
11860269
uniprot
proteins
pubmed
1448170
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7913472
uniprot
proteins
pubmed
8099882
uniprot
proteins
sequence_length
573
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1448170, ECO:0000269|PubMed:7913472}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P43004}.
uniprot
proteins
transmembrane_region
TRANSMEM 45..64; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 88..108; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 121..142; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 235..258; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 268..295; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 317..338; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 384..410; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 471..492; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P43003
uniprot
proteins