GFPT2
entrez
9945
canonical
uniprot
O94808
canonical
ensembl
ENSG00000131459
resolver
ensp
ENSP00000253778
resolver
enst
ENST00000253778
resolver
genesymbol
GFPT2
resolver
hgnc
HGNC:4242
resolver
uniprot
A0A0S2Z4X9
resolver
uniprot
B3KMR8
resolver
uniprot
Q53XM2
resolver
uniprot
Q9BWS4
resolver
uniprot_entry
A0A0S2Z4X9_HUMAN
resolver
uniprot_entry
B3KMR8_HUMAN
resolver
uniprot_entry
GFPT2_HUMAN
resolver
uniprot_sec
Q53XM2
resolver
uniprot_sec
Q9BWS4
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by UDP-GlcNAc. {ECO:0000269|PubMed:35229715}.
uniprot
proteins
amino_acid_sequence
MCGIFAYMNYRVPRTRKEIFETLIKGLQRLEYRGYDSAGVAIDGNNHEVKERHIQLVKKRGKVKALDEELYKQDSMDLKVEFETHFGIAHTRWATHGVPSAVNSHPQRSDKGNEFVVIHNGIITNYKDLRKFLESKGYEFESETDTETIAKLIKYVFDNRETEDITFSTLVERVIQQLEGAFALVFKSVHYPGEAVATRRGSPLLIGVRSKYKLSTEQIPILYRTCTLENVKNICKTRMKRLDSSACLHAVGDKAVEFFFASDASAIIEHTNRVIFLEDDDIAAVADGKLSIHRVKRSASDDPSRAIQTLQMELQQIMKGNFSAFMQKEIFEQPESVFNTMRGRVNFETNTVLLGGLKDHLKEIRRCRRLIVIGCGTSYHAAVATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTLLALRYCKDRGALTVGVTNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFISLVMFGLMMSEDRISLQNRRQEIIRGLRSLPELIKEVLSLEEKIHDLALELYTQRSLLVMGRGYNYATCLEGALKIKEITYMHSEGILAGELKHGPLALIDKQMPVIMVIMKDPCFAKCQNALQQVTARQGRPIILCSKDDTESSKFAYKTIELPHTVDCLQGILSVIPLQLLSFHLAVLRGYDVDFPRNLAKSVTVE
uniprot
proteins
ec_number
2.6.1.16
uniprot
proteins
function
FUNCTION: Rate-limiting enzyme of the hexosamine biosynthetic pathway (HBP) that catalyzes the formation of glucosamine-6-phosphate from fructose-6-phosphate and glutamine, thereby controlling the flux of glucose into this pathway (PubMed:35229715). Via control of the HPB, likely regulates the availability of precursors for N- and O-linked protein glycosylation (By similarity). Exhibits feedback inhibition by UDP-N-acetylglucosamine (UDP-GlcNAc), although to a lesser extent than GFPT1 (PubMed:35229715). {ECO:0000250|UniProtKB:Q06210, ECO:0000269|PubMed:35229715}.
uniprot
proteins
mass_dalton
76931
uniprot
proteins
pathway_participation
PATHWAY: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1. {ECO:0000269|PubMed:35229715}.
uniprot
proteins
pubmed
10198162
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
35229715
uniprot
proteins
sequence_length
682
uniprot
proteins