Dtx4
entrez
207521
canonical
uniprot
Q6PDK8
canonical
ensembl
ENSMUSG00000039982
resolver
ensp
ENSMUSP00000040229
resolver
enst
ENSMUST00000045521
resolver
genesymbol
Dtx4
resolver
uniprot
Q6IS30
resolver
uniprot
Q8BID3
resolver
uniprot_entry
DTX4_MOUSE
resolver
uniprot_sec
Q6IS30
resolver
uniprot_sec
Q8BID3
resolver
amino_acid_sequence
MLLASAVVVWEWLNEHGRWRPYSPAVSHHIEAVVRAGPRAGGSVVLGQVDSRLAPYIIDLQSMNQFRQDTGTLRPVRRNYYDPSSAPGKGVVWEWENDNGSWTPYDMEVGITIQYAYEKQHPWIDLTSIGFSYIIDFSTMGQINRQTQRQRRVRRRLDLIYPMVTGTMPKTQSWPVSPGPATSSPAPPCSCPQCVLVMSVKAAVVHGGTGPPAVRKNMALSGVGKLPQPPGPGAKPLDTTGTIRGPGKTAPSQVIRRQVSNAPAGATVGSPASPQGSNRKTGRVALATLNRSNLQRLAIAQSRVLIASGVPTVPVKNLNGSSPVNPALAGITGILMSAAGLPVCLTRPPKLVLHPPPVSKSEIKSIPGVSNTSRKTTKKQAKKGKTPEEVLKKYLQKVRHPPEEDCTICMERLTAPSGYKGPQPTVKPDLVGKLSRCGHIYHIYCLVAMYNNGNKDGSLQCPTCKTIYGVKTGTQPPGKMEYHLIPHSLPGHPDCKTIRIIYSIPPGIQGPEHPNPGKSFSARGFPRHCYLPDSEKGRKVLKLLLVAWDRRLIFAIGTSSTTGESDTVIWNEVHHKTEFGSNLTGHGYPDANYLDNVLAELAAQGISEDSTSHEKD
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4 (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. {ECO:0000250, ECO:0000269|PubMed:16923970}.
uniprot
proteins
mass_dalton
66821
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
Deltex family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15684394
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16923970
uniprot
proteins
sequence_length
616
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins