Slc38a4
entrez
170573
canonical
uniprot
Q9EQ25
canonical
ensembl
ENSRNOG00000006653
resolver
ensembl
ENSRNOG00055012724
resolver
ensembl
ENSRNOG00060006956
resolver
ensembl
ENSRNOG00065019162
resolver
ensp
ENSRNOP00000009187
resolver
ensp
ENSRNOP00055017628
resolver
ensp
ENSRNOP00060008522
resolver
ensp
ENSRNOP00065025735
resolver
enst
ENSRNOT00000009187
resolver
enst
ENSRNOT00055021743
resolver
enst
ENSRNOT00060011398
resolver
enst
ENSRNOT00065032227
resolver
genesymbol
Slc38a4
resolver
genesymbol_syn
Ata3
resolver
genesymbol_syn
Snat4
resolver
uniprot_entry
S38A4_RAT
resolver
amino_acid_sequence
MDPIELRSVNIEPYEDSCSVDSIQSCYTGMGNSEKGAMDSQFANEDAESQKFLTNGFLGKKTLTDYADEHHPGTTSFGMSSFNLSNAIMGSGILGLSYAMANTGIVLFVIMLLTVAILSLYSVHLLLKTAKEGGSLIYEKLGEKAFGWPGKIGAFISITMQNIGAMSSYLFIIKYELPEVIRVFMGLEENTGEWYLNGNYLVLFVSVGIILPLSLLKNLGYLGYTSGFSLTCMVFFVSVVIYKKFQIPCPLPVLDHNNGNLTFNNTLPMHVIMLPNNSESTGMNFMVDYTHRDPEGLDEKPAAGPLHGSGVEYEAHSGDKCQPKYFVFNSRTAYAIPILAFAFVCHPEVLPIYSELKDRSRRKMQTVSNISITGMLVMYLLAALFGYLSFYGEVEDELLHAYSKVYTFDTALLMVRLAVLVAVTLTVPIVLFPIRTSVITLLFPRRPFSWVKHFGIAAIIIALNNVLVILVPTIKYIFGFIGASSATMLIFILPAAFYLKLVKKEPLRSPQKIGALVFLVTGIIFMMGSMALIIIDWIYNPPNPDHH
uniprot
proteins
function
FUNCTION: Symporter that cotransports neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane (PubMed:11118514). The transport is electrogenic, pH dependent and partially tolerates substitution of Na(+) by Li(+) (PubMed:11118514). Preferentially transports smaller amino acids, such as glycine, L-alanine, L-serine, L-asparagine and L-threonine, followed by L-cysteine, L-histidine, L-proline and L-glutamine and L-methionine (PubMed:11118514). {ECO:0000269|PubMed:11118514}.
uniprot
proteins
mass_dalton
60613
uniprot
proteins
post_translational_modification
PTM: The disulfide bond plays an important role in substrate transport, but has no effect on trafficking to the cell surface. {ECO:0000250|UniProtKB:Q8R1S9}.
uniprot
proteins
protein_family
Amino acid/polyamine transporter 2 family
uniprot
proteins
pubmed
11118514
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
547
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q969I6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q969I6}. Cell projection, microvillus membrane {ECO:0000250|UniProtKB:Q969I6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q969I6}. Note=Microvillus membrane localization in placenta. {ECO:0000250|UniProtKB:Q969I6}.
uniprot
proteins
transmembrane_region
TRANSMEM 105..125; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 152..172; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 196..216; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 221..241; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 333..353; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 370..390; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 412..432; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 454..474; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 477..497; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 515..535; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins