Jph4
entrez
445271
canonical
uniprot
Q69FB3
canonical
ensembl
ENSRNOG00000025619
resolver
ensp
ENSRNOP00000036180
resolver
genesymbol
Jph4
resolver
genesymbol_syn
Jphl1
resolver
uniprot_entry
JPH4_RAT
resolver
amino_acid_sequence
MHVPLGRKFDFDDGGCYVGGWEAGRAHGYGVCTGPGAQGEYSGCWAHGFESLGVFTGPGGHSYQGHWQQGKREGLGVERKSRWTYRGEWLGGLKGRSGVWESVSGLRYAGLWKDGFQDGYGTETYSDGGTYQGQWQAGKRHGYGVRQSVPYHQAALLRSPRRTSLDSGHSDPPTPPPPLPLPGDEGGSPASGSRGGFVLAGPGDADGASSRKRTPAAGGFFRRSLLLSGLRAGGRRSSLGSKRGSLRSEVSSEVGSTGPPGSEASGPPIPAPPALIEGSATEVYAGEWRADRRSGYGVSQRSNGLRYEGEWLGNRRHGYGRTTRPDGSREEGKYKRNRLVHGGRVRSLLPLALRRGKVKEKVDRAVEGARRAVSAARQRQEIAAARAADALLKAVAASSVAEKAVEAARMAKLIAQDLQPMLEAPGRRPRQDSGGSDTEPLDEDSPGVYENGLTPSEGSPELPSSPASSHQPWRAPPCRSPLPPGGNWGPFSSPKAWPEEWGGPGEQAEELAGYEAEDEAGMQGPGPRDGSPLLGGCSDSSGSLREEEGEDEESLPQLRAPGGSESEPVTTPVLRGLSSRGPDAGCLTEEFEEPAATERPAQPGAANPLVVGAVALLDLSLAFLFSQLLT
uniprot
proteins
function
FUNCTION: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
66441
uniprot
proteins
protein_family
Junctophilin family
uniprot
proteins
sequence_length
630
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q9ET77}. Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane (By similarity). {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 609..629; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins