C22orf39
entrez
128977
canonical
uniprot
Q6P5X5
canonical
ensembl
ENSG00000242259
resolver
ensp
ENSP00000382474
resolver
ensp
ENSP00000382478
resolver
genesymbol
C22orf39
resolver
hgnc
HGNC:27012
resolver
uniprot
A0A075B6P1
resolver
uniprot
A8MTW6
resolver
uniprot
D3DX18
resolver
uniprot
F5H3A8
resolver
uniprot
J3KNP9
resolver
uniprot_entry
CV039_HUMAN
resolver
uniprot_sec
A0A075B6P1
resolver
uniprot_sec
A8MTW6
resolver
uniprot_sec
D3DX18
resolver
uniprot_sec
F5H3A8
resolver
uniprot_sec
J3KNP9
resolver
amino_acid_sequence
MADGSGWQPPRPCEAYRAEWKLCRSARHFLHHYYVHGERPACEQWQRDLASCRDWEERRNAEAQQSLCESERARVRAARKHILVWAPRQSPPPDWHLPLPQEKDE
uniprot
proteins
function
FUNCTION: Negatively regulates long-term potentiation and modulates adult synaptic plasticity. Stabilizes the interaction of RTN4 isoform A/Nogo-A with its receptors, inhibiting clustering of postsynaptic AMPA receptors at synaptic sites. Upon neuronal stimulation, degraded at synapses, reducing RTN4 signaling and allowing AMPA receptor clustering at individual synapses. {ECO:0000250|UniProtKB:Q3U595}.
uniprot
proteins
mass_dalton
12540
uniprot
proteins
post_translational_modification
PTM: Rapidly degraded by proteolysis following neuronal stimulation, resulting in increased AMPA receptor clustering. {ECO:0000250|UniProtKB:Q3U595}.
uniprot
proteins
protein_family
UPF0545 family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
105
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Synapse {ECO:0000250|UniProtKB:Q3U595}. Synaptic cleft {ECO:0000250|UniProtKB:Q3U595}. Note=Detected in both the presynaptic and postsynaptic regions of the synapse and is secreted from neurons into the synaptic cleft. May be released by neuronal dense core vesicles which mediate the release of cleaved neuropeptides. {ECO:0000250|UniProtKB:Q3U595}.
uniprot
proteins