Bik
entrez
12124
canonical
uniprot
O70337
canonical
ensembl
ENSMUSG00000016758
resolver
ensp
ENSMUSP00000016902
resolver
ensp
ENSMUSP00000155083
resolver
ensp
ENSMUSP00000155439
resolver
ensp
ENSMUSP00000224651
resolver
enst
ENSMUST00000016902
resolver
enst
ENSMUST00000230912
resolver
genesymbol
Bik
resolver
genesymbol_syn
Biklk
resolver
genesymbol_syn
Blk
resolver
genesymbol_syn
Nbk
resolver
uniprot_entry
BIK_MOUSE
resolver
amino_acid_sequence
MSEARLMARDVIKTVPHDQVPQPPVASETPSMKEPVRDVDLMECVEGRNQVALRLACIGDEMDLCLRSPRLVQLPGIAIHRLAVTYSRTGVRGIFRSLIRSLTNLRENIWSWRVLTPGAWVSPDQDPGQLFPMVLLVFLLLGGAWYLQLQ
uniprot
proteins
function
FUNCTION: Accelerates programmed cell death. Binding to the apoptosis repressors Bcl-X(L), BHRF1 or Bcl-2 suppresses this death-promoting activity. {ECO:0000269|PubMed:9525867}.
uniprot
proteins
mass_dalton
16901
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage is a necessary step prior its degradation by the proteosome-dependent mechanism. {ECO:0000250|UniProtKB:Q13323}.; PTM: Ubiquitinated by the ECS(ASB11) complex in response to endoplasmic reticulum stress, leading to substrate recognition by the segregase p97/VCP and degradation by the proteasome. {ECO:0000250|UniProtKB:Q13323}.
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
9525867
uniprot
proteins
sequence_length
150
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250|UniProtKB:Q13323}; Single-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000269|PubMed:9525867}; Single-pass membrane protein {ECO:0000255}. Note=Around the nuclear envelope, and in cytoplasmic membranes. {ECO:0000250|UniProtKB:Q13323}.
uniprot
proteins
transmembrane_region
TRANSMEM 127..147; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins