Cavin2
entrez
20324
canonical
uniprot
Q63918
canonical
ensembl
ENSMUSG00000045954
resolver
ensp
ENSMUSP00000055694
resolver
enst
ENSMUST00000051572
resolver
genesymbol
Cavin2
resolver
genesymbol_syn
Sdpr
resolver
genesymbol_syn
Sdr
resolver
uniprot
Q3V1P6
resolver
uniprot
Q78EC3
resolver
uniprot
Q8CBT4
resolver
uniprot_entry
CAVN2_MOUSE
resolver
uniprot_sec
Q3V1P6
resolver
uniprot_sec
Q78EC3
resolver
uniprot_sec
Q8CBT4
resolver
amino_acid_sequence
MGEDAAQAEKFQHPNTDMLQEKPSSPSPMPSSTPSPSLNLGSTEEAIRDNSQVNAVTVHTLLDKLVNMLDAVRENQHNMEQRQINLEGSVKGIQNDLTKLSKYQASTSNTVSKLLEKSRKVSAHTRAVRERLERQCVQVKRLENNHAQLLRRNHFKVLIFQEESEIPASVFVKEPVPSAAEGKEELADENKSLEETLHNVDLSSDDELPRDEEALEDSAEEKMEESRAEKIKRSSLKKVDSLKKAFSRQNIEKKMNKLGTKIVSVERREKIKKSLTPNHQKASSGKSSPFKVSPLSFGRKKVREGESSVENETKLEDQMQEDREEGSFTEGLSEASLPSGLMEGSAEDAEKSARRGNNSAVGSNADLTIEEDEEEEPVALQQAQQVRYESGYMLNSEEMEEPSEKQVQPAVLHVDQTA
uniprot
proteins
function
FUNCTION: Plays an important role in caveolar biogenesis and morphology. Regulates caveolae morphology by inducing membrane curvature within caveolae (By similarity). Plays a role in caveola formation in a tissue-specific manner. Required for the formation of caveolae in the lung and fat endothelia but not in the heart endothelia. Negatively regulates the size or stability of CAVIN complexes in the lung endothelial cells (PubMed:23652019). May play a role in targeting PRKCA to caveolae (By similarity). {ECO:0000250|UniProtKB:O95810, ECO:0000250|UniProtKB:Q66H98, ECO:0000269|PubMed:23652019}.
uniprot
proteins
mass_dalton
46764
uniprot
proteins
post_translational_modification
PTM: The N-terminus is blocked. {ECO:0000250}.
uniprot
proteins
protein_family
CAVIN family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18332105
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19546242
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23652019
uniprot
proteins
pubmed
25588833
uniprot
proteins
pubmed
8241023
uniprot
proteins
sequence_length
418
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18332105, ECO:0000269|PubMed:19546242}. Membrane, caveola {ECO:0000269|PubMed:19546242}. Note=Localizes in the caveolae in a caveolin-dependent manner. {ECO:0000269|PubMed:19546242}.
uniprot
proteins