S-adenosyl-L-methionine
cv_term_accession
KW-0949
canonical
uniprot_keyword
KW-0949
canonical
name
S-adenosyl-L-methionine
uniprot
synonym
AdoMet
uniprot
synonym
AdoMet radical
uniprot
synonym
S-adenosyl methionine
uniprot
synonym
S-adenosyl-methionine
uniprot
synonym
S-adenosylmethionine
uniprot
synonym
SAM
uniprot
synonym
SAM radical
uniprot
synonym
radical S- adenosylmethionine
uniprot
definition
Protein which binds at least one S-adenosyl-L-methionine (SAM), or protein whose function is SAM-dependent. S-adenosyl-L-methionine, a conjugate of the nucleotide adenosine and the amino acid methionine, is a substrate/cofactor in numerous enzyme-catalyzed reactions. Enzymatic reactions that involve interactions of proteins with S- adenosyl-L-methionine include transfer of methyl, thiomethyl, aminoalkyl and adenosyl groups. It not only provides methyl groups to be transferred in numerous biological reactions, but also acts as a precursor in the biosynthesis of polyamines and metal ion chelating compounds. It is also a source of catalytic 5'-deoxyadenosyl radicals produced as reaction intermediates by a superfamily of radical enzymes. It is also involved in decarboxylation reactions.
uniprot
keywords
is_obsolete
false
uniprot
keywords
ontology_id
uniprot_keywords
uniprot
keywords