Dusp6
entrez
67603
canonical
uniprot
Q9DBB1
canonical
ensembl
ENSMUSG00000019960
resolver
ensp
ENSMUSP00000020118
resolver
ensp
ENSMUSP00000151438
resolver
enst
ENSMUST00000020118
resolver
enst
ENSMUST00000220291
resolver
genesymbol
Dusp6
resolver
genesymbol_syn
Mkp3
resolver
uniprot
A0A1W2P715
resolver
uniprot
Q542I5
resolver
uniprot
Q9D7L4
resolver
uniprot_entry
A0A1W2P715_MOUSE
resolver
uniprot_entry
DUS6_MOUSE
resolver
uniprot_sec
Q542I5
resolver
uniprot_sec
Q9D7L4
resolver
amino_acid_sequence
MIDTLRPVPFASEMAICKTVSWLNEQLELGNERLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRCEDRDRFTRRCGTDTVVLYDENSSDWNENTGGESVLGLLLKKLKDEGCRAFYLEGGFSKFQAEFALHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDIESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPTPQLYFTTPSNQNVYQVDSLQST
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases. Has a specificity for the ERK family (By similarity). Plays an important role in alleviating acute postoperative pain (PubMed:24155322, PubMed:28405172). Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (PubMed:24155322). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (PubMed:28405172). {ECO:0000250|UniProtKB:Q16828, ECO:0000269|PubMed:24155322, ECO:0000269|PubMed:28405172}.
uniprot
proteins
mass_dalton
42408
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the SCF(FBXO31) complex, leading to its proteasomal degradation. {ECO:0000250|UniProtKB:Q16828}.
uniprot
proteins
protein_family
Non-receptor class dual specificity subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
24155322
uniprot
proteins
pubmed
28405172
uniprot
proteins
sequence_length
381
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q16828}.
uniprot
proteins