SLC5A4
entrez
6527
canonical
uniprot
Q9NY91
canonical
ensembl
ENSG00000100191
resolver
ensp
ENSP00000266086
resolver
enst
ENST00000266086
resolver
genesymbol
SLC5A4
resolver
genesymbol_syn
SAAT1
resolver
genesymbol_syn
SGLT3
resolver
hgnc
HGNC:11039
resolver
uniprot
O15279
resolver
uniprot_entry
SC5A4_HUMAN
resolver
uniprot_sec
O15279
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by phlorizin. {ECO:0000269|PubMed:13130073, ECO:0000269|PubMed:17110502, ECO:0000269|PubMed:22766068}.
uniprot
proteins
amino_acid_sequence
MASTVSPSTIAETPEPPPLSDHIRNAADISVIVIYFLVVMAVGLWAMLKTNRGTIGGFFLAGRDMAWWPMGASLFASNIGSNHYVGLAGTGAASGVATVTFEWTSSVMLLILGWIFVPIYIKSGVMTMPEYLKKRFGGERLQVYLSILSLFICVVLLISADIFAGAIFIKLALGLDLYLAIFILLAMTAVYTTTGGLASVIYTDTLQTIIMLIGSFILMGFAFNEVGGYESFTEKYVNATPSVVEGDNLTISASCYTPRADSFHIFRDAVTGDIPWPGIIFGMPITALWYWCTNQVIVQRCLCGKDMSHVKAACIMCAYLKLLPMFLMVMPGMISRILYTDMVACVVPSECVKHCGVDVGCTNYAYPTMVLELMPQGLRGLMLSVMLASLMSSLTSIFNSASTLFTIDLYTKMRKQASEKELLIAGRIFVLLLTVVSIVWVPLVQVSQNGQLIHYTESISSYLGPPIAAVFVLAIFCKRVNEQGAFWGLMVGLAMGLIRMITEFAYGTGSCLAPSNCPKIICGVHYLYFSIVLFFGSMLVTLGISLLTKPIPDVHLYRLCWVLRNSTEERIDIDAEEKSQEETDDGVEEDYPEKSRGCLKKAYDLFCGLQKGPKLTKEEEEALSKKLTDTSERPSWRTIVNINAILLLAVVVFIHGYYA
uniprot
proteins
function
FUNCTION: Does not function as sodium/D-glucose symporter (PubMed:13130073, PubMed:20421923, PubMed:22766068). However, may function as a D-glucose sensor by generating a D-glucose-induced depolarization which is pH-independent, Na(+)-dependent at neutral pH and probably H(+)-dependent at acidic pH (PubMed:13130073, PubMed:17110502, PubMed:20421923, PubMed:22766068). {ECO:0000269|PubMed:13130073, ECO:0000269|PubMed:17110502, ECO:0000269|PubMed:20421923, ECO:0000269|PubMed:22766068}.
uniprot
proteins
mass_dalton
72456
uniprot
proteins
mutagenesis
MUTAGEN 457; /note="E->Q: Confers sugar transport activity not found in the wild-type protein. Increased sensitivity to inhibitor phlorizin."; /evidence="ECO:0000269|PubMed:20421923
uniprot
proteins
protein_family
Sodium:solute symporter (SSF) (TC 2.A.21) family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
13130073
uniprot
proteins
pubmed
17110502
uniprot
proteins
pubmed
20421923
uniprot
proteins
pubmed
22766068
uniprot
proteins
sequence_length
659
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:13130073, ECO:0000305|PubMed:17110502, ECO:0000305|PubMed:20421923, ECO:0000305|PubMed:22766068}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 29..47; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 65..85; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 106..126; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 172..191; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 209..229; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 271..291; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 315..334; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 424..443; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 456..476; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 527..547; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 638..658; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins