Notum
entrez
77583
canonical
uniprot
Q8R116
canonical
ensembl
ENSMUSG00000042988
resolver
ensp
ENSMUSP00000101783
resolver
ensp
ENSMUSP00000101784
resolver
ensp
ENSMUSP00000185557
resolver
ensp
ENSMUSP00000185559
resolver
genesymbol
Notum
resolver
uniprot
A2ABZ5
resolver
uniprot
A2ABZ6
resolver
uniprot_entry
NOTUM_MOUSE
resolver
uniprot_sec
A2ABZ5
resolver
uniprot_sec
A2ABZ6
resolver
amino_acid_sequence
MGGEVRVLLLLGLLHWVGGSEGRKTWRRRGQQPPQPPPPPPLPQRAEVEPGAGQPVESFPLDFTAVEGNMDSFMAQVKSLAQSLYPCSAQQLNEDLRLHLLLNTSVTCNDGSPAGYYLKESKGSRRWLLFLEGGWYCFNRENCDSRYSTMRRLMSSKDWPHTRTGTGILSSQPEENPHWWNANMVFIPYCSSDVWSGASPKSDKNEYAFMGSLIIQEVVRELLGKGLSGAKVLLLAGSSAGGTGVLLNVDRVAELLEELGYPSIQVRGLADSGWFLDNKQYRRSDCIDTINCAPTDAIRRGIRYWSGMVPERCQRQFKEGEEWNCFFGYKVYPTLRCPVFVVQWLFDEAQLTVDNVHLTGQPVQEGQWLYIQNLGRELRGTLKDVQASFAPACLSHEIIIRSYWTDVQVKGTSLPRALHCWDRSFHDSHKASKTPMKGCPFHLVDSCPWPHCNPSCPTIRDQFTGQEMNVAQFLMHMGFDVQTVAQQQGMEPSKLLGMLSNGN
uniprot
proteins
ec_number
3.1.1.98
uniprot
proteins
function
FUNCTION: Carboxylesterase that acts as a key negative regulator of the Wnt signaling pathway by specifically mediating depalmitoleoylation of WNT proteins. Serine palmitoleoylation of WNT proteins is required for efficient binding to frizzled receptors. {ECO:0000269|PubMed:25771893}.
uniprot
proteins
mass_dalton
56584
uniprot
proteins
mutagenesis
MUTAGEN 239; /note="S->A: Abolishes enzyme activity. Unable to mediate serine depalmitoleoylation of WNT proteins."; /evidence="ECO:0000269|PubMed:25771893
uniprot
proteins
protein_family
Notum subfamily
uniprot
proteins
protein_family
Pectinacetylesterase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17967162
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
25771893
uniprot
proteins
sequence_length
503
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9VUX3}.
uniprot
proteins