Cox18
entrez
231430
canonical
uniprot
Q8VC74
canonical
ensembl
ENSMUSG00000035505
resolver
ensp
ENSMUSP00000044144
resolver
ensp
ENSMUSP00000113353
resolver
enst
ENSMUST00000048363
resolver
enst
ENSMUST00000118816
resolver
genesymbol
Cox18
resolver
genesymbol_syn
Oxa1l2
resolver
uniprot
A6H626
resolver
uniprot
G3X965
resolver
uniprot
G5E8U6
resolver
uniprot
Q3U1D5
resolver
uniprot_entry
COX18_MOUSE
resolver
uniprot_entry
G5E8U6_MOUSE
resolver
uniprot_sec
A6H626
resolver
uniprot_sec
G3X965
resolver
uniprot_sec
Q3U1D5
resolver
amino_acid_sequence
MLCRSCAGWLRSLPTLRLPAPGSPPAWSSARLPALPVWAAASVSAASPGGWYEALAASAPVRTAEEVLLGAQEATGLPWWSNIILSTVALRGAVTLPLAAYQHYILAKVENLQPEIKDIAKRLNQEVAVCARQFGWSKRVARLTYLKNMRRLISELYVRDNCHPFKATVLVWVQLPMWVFISVALRNLSTGATHSDGISVQEQLAAGGTLWFPDLTAVDSTWILPVSVGVVNLLIVEIFALQKIGTSRFQMYVTNFVRAVSVLMIPVAATVPSALVLYWLCSSLMGLAQNLLLRSPGFRQLCRIPPSKSDSETPYRDLSAAFCAKFLSRKR
uniprot
proteins
function
FUNCTION: Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT-CO2/COX2) across the mitochondrial inner membrane. Plays a role in MT-CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2. Essential for the assembly and stability of the mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase). {ECO:0000250|UniProtKB:Q8N8Q8}.
uniprot
proteins
mass_dalton
36303
uniprot
proteins
protein_family
OXA1/ALB3/YidC family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
331
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q8N8Q8}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 165..185; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 221..241; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 260..280; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins