Prrx1
entrez
266813
canonical
uniprot
P63014
canonical
ensembl
ENSRNOG00000003720
resolver
ensembl
ENSRNOG00055017540
resolver
ensembl
ENSRNOG00060009034
resolver
ensembl
ENSRNOG00065020464
resolver
ensp
ENSRNOP00000004950
resolver
ensp
ENSRNOP00000075169
resolver
genesymbol
Prrx1
resolver
uniprot
P43271
resolver
uniprot
Q02810
resolver
uniprot
Q643W9
resolver
uniprot_entry
PRRX1_RAT
resolver
uniprot_sec
P43271
resolver
uniprot_sec
Q02810
resolver
uniprot_sec
Q643W9
resolver
amino_acid_sequence
MTSSYGHVLERQPALGGRLDSPGNLDTLQAKKNFSVSHLLDLEEAGDMVAAQADESVGEAGRSLLESPGLTSGSDTPQQDNDQLNSEEKKKRKQRRNRTTFNSSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFRRNERAMLANKNASLLKSYSGDVTAVEQPIVPRPAPRPTDYLSWGTASPYSAMATYSATCANNSPAQGINMANSIANLRLKAKEYSLQRNQVPTVN
uniprot
proteins
function
FUNCTION: Master transcription factor of stromal fibroblasts for myofibroblastic lineage progression. Orchestrates the functional drift of fibroblasts into myofibroblastic phenotype via TGF-beta signaling by remodeling a super-enhancer landscape. Through this function, plays an essential role in wound healing process. Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer. May play a role in homeostasis and regeneration of bone, white adipose tissue and derm. {ECO:0000250|UniProtKB:P63013}.; FUNCTION: [Isoform 1]: Transcriptional activator, when transfected in fibroblastic or myoblastic cell lines. This activity may be masked by the C-terminal OAR domain. {ECO:0000250|UniProtKB:P63013}.; FUNCTION: [Isoform 2]: Transcriptional repressor, when transfected in fibroblastic or myoblastic cell lines. {ECO:0000250|UniProtKB:P63013}.
uniprot
proteins
mass_dalton
27269
uniprot
proteins
protein_family
Paired homeobox family
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8749718
uniprot
proteins
sequence_length
245
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P63013, ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138}.
uniprot
proteins