Itgb6
entrez
16420
canonical
uniprot
Q9Z0T9
canonical
ensembl
ENSMUSG00000026971
resolver
ensp
ENSMUSP00000028348
resolver
ensp
ENSMUSP00000054944
resolver
ensp
ENSMUSP00000117815
resolver
ensp
ENSMUSP00000169437
resolver
ensp
ENSMUSP00000169443
resolver
enst
ENSMUST00000028348
resolver
enst
ENSMUST00000059888
resolver
genesymbol
Itgb6
resolver
uniprot
Q544J9
resolver
uniprot_entry
ITB6_MOUSE
resolver
uniprot_sec
Q544J9
resolver
amino_acid_sequence
MGIELVCLFLLLLGRNDHVQGGCAWGGAESCSDCLLTGPHCAWCSQENFTHLSGAGERCDTPANLLAKGCQLPFIENPVSRIEVLQNKPLSVGRQKNSSDIVQIAPQSLVLKLRPGREQTLQVQVRQTEDYPVDLYYLMDLSASMDDDLNTIKELGSRLAKEMSKLTSNFRLGFGSFVEKPVSPFMKTTPEEITNPCSSIPYFCLPTFGFKHILPLTDDAERFNEIVRKQKISANIDTPEGGFDAIMQAAVCKEKIGWRNDSLHLLVFVSDADSHFGMDSKLAGIVIPNDGLCHLDHRNEYSMSTVLEYPTIGQLIDKLVQNNVLLIFAVTQEQVHLYENYAKLIPGATVGLLQKDSGNILQLIISAYEELRSEVELEVLGDTEGLNLSFTALCNNGVLFPHQKKCSHMKVGDTASFNVTVSVSNCEKRSRNLIIKPVGLGDTLEILVSAECDCDCQREIETNSSKCHNGNGSFQCGVCTCNPGHMGPHCECGEDMVSTDSCKESPGHPSCSGRGDCYCGQCICHLSPYGSIYGPYCQCDNFSCLRHKGLLCGDNGDCDCGECVCRDGWTGEYCNCTTNRDSCTSEDGVLCSGRGDCVCGKCVCRNPGASGPTCERCPTCGDPCNSKRSCIECYLSADGQAQEECADKCKAIGATISEEDFSKDTSVSCSLQGENECLITFLITTDNEGKTIIHNINEKDCPKPPNIPMIMLGVSLAILLIGVVLLCIWKLLVSFHDRKEVAKFEAERSKAKWQTGTNPLYRGSTSTFKNVTYKHREKHKAGLSSDG
uniprot
proteins
function
FUNCTION: Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (PubMed:10025398). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:10025398). {ECO:0000250|UniProtKB:P18564, ECO:0000269|PubMed:10025398}.
uniprot
proteins
mass_dalton
86042
uniprot
proteins
protein_family
Integrin beta chain family
uniprot
proteins
pubmed
10025398
uniprot
proteins
pubmed
11095652
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
36268721
uniprot
proteins
sequence_length
787
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:36268721}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P18564}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P18564}. Note=Localized to intercalated disks in the heart. {ECO:0000269|PubMed:36268721}.
uniprot
proteins
transmembrane_region
TRANSMEM 709..729; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins