Sgpp2
entrez
433323
canonical
uniprot
Q810K3
canonical
ensembl
ENSMUSG00000032908
resolver
ensp
ENSMUSP00000036656
resolver
ensp
ENSMUSP00000208639
resolver
enst
ENSMUST00000036172
resolver
genesymbol
Sgpp2
resolver
uniprot
B2RWL5
resolver
uniprot_entry
SGPP2_MOUSE
resolver
uniprot_sec
B2RWL5
resolver
amino_acid_sequence
MAELLRSLRDSQLVARFQRRCGLFPAREASGEEHVVKNYFYYYLFRFSAALGQEVFYITFLPFTHWNIDPNLSRRLVVIWVLVMYIGQVAKDILKWPRPSFPPVVRLEKRIIAEYGMPSTHAMAATAISFTLLISTMDRYQYPFILGLMMAVVFSTLVCLSRLYTGMHTVLDILGGVLITAVLIALTYPAWTLIDSLDSASPLFPVCVIVVPFLLCYNYPVSDYYSPTRADTTTIVAAGAGVTLGFWINHFFQLVSKPTPSLPVIQNIPPLTTDMLVLGLTKFMVGIMLILLVRQLVQKLSLQVLFSWFKVVTRNKEARRRLEIEVPYKFVTYTSVGICATTFVPMLHRFLGLL
uniprot
proteins
ec_number
3.1.3.-
uniprot
proteins
function
FUNCTION: Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro (Probable). Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway (By similarity). May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling (By similarity). Plays a role in the regulation of pancreatic islet beta-cell endoplasmic reticulum stress and proliferation (PubMed:27059959). {ECO:0000250|UniProtKB:Q8IWX5, ECO:0000250|UniProtKB:Q9BX95, ECO:0000269|PubMed:27059959, ECO:0000305|PubMed:27059959}.
uniprot
proteins
mass_dalton
40248
uniprot
proteins
protein_family
Type 2 lipid phosphate phosphatase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19073640
uniprot
proteins
pubmed
27059959
uniprot
proteins
sequence_length
354
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8IWX5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8IWX5}.
uniprot
proteins
transmembrane_region
TRANSMEM 43..63; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 76..96; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 115..135; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 140..160; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 173..193; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 202..222; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 235..255; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 273..293; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 334..354; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins