Tlr12
entrez
384059
canonical
uniprot
Q6QNU9
canonical
ensembl
ENSMUSG00000062545
resolver
ensp
ENSMUSP00000074381
resolver
enst
ENSMUST00000074829
resolver
genesymbol
Tlr12
resolver
genesymbol_syn
Gm1365
resolver
genesymbol_syn
Tlr11
resolver
uniprot
A2RRZ9
resolver
uniprot_entry
A2RRZ9_MOUSE
resolver
uniprot_entry
TLR12_MOUSE
resolver
amino_acid_sequence
MGRYWLLPGLLLSLPLVTGWSTSNCLVTEGSRLPLVSRYFTFCRHSKLSFLAACLSVSNLTQTLEVVPRTVEGLCLGGTVSTLLPDAFSAFPGLKVLALSLHLTQLLPGALRGLGQLQSLSFFDSPLRRSLFLPPDAFSDLISLQRLHISGPCLDKKAGIRLPPGLQWLGVTLSCIQDVGELAGMFPDLVQGSSSRVSWTLQKLDLSSNWKLKMASPGSLQGLQVEILDLTRTPLDAVWLKGLGLQKLDVLYAQTATAELAAEAVAHFELQGLIVKESKIGSISQEALASCHSLKTLGLSSTGLTKLPPGFLTAMPRLQRLELSGNQLQSAVLCMNETGDVSGLTTLDLSGNRLRILPPAAFSCLPHLRELLLRYNQLLSLEGYLFQELQQLETLKLDGNPLLHLGKNWLAALPALTTLSLLDTQIRMSPEPGFWGAKNLHTLSLKLPALPAPAVLFLPMYLTSLELHIASGTTEHWTLSPAIFPSLETLTISGGGLKLKLGSQNASGVFPALQKLSLLKNSLDAFCSQGTSNLFLWQLPKLQSLRVWGAGNSSRPCLITGLPSLRELKLASLQSITQPRSVQLEELVGDLPQLQALVLSSTGLKSLSAAAFQRLHSLQVLVLEYEKDLMLQDSLREYSPQMPHYIYILESNLACHCANAWMEPWVKRSTKTYIYIRDNRLCPGQDRLSARGSLPSFLWDHCPQTLELKLFLASSALVFMLIALPLLQEARNSWIPYLQALFRVWLQGLRGKGDKGKRFLFDVFVSHCRQDQGWVIEELLPALEGFLPAGLGLRLCLPERDFEPGKDVVDNVVDSMLSSRTTLCVLSGQALCNPRCRLELRLATSLLLAAPSPPVLLLVFLEPISRHQLPGYHRLARLLRRGDYCLWPEEEERKSGFWTWLRSRLG
uniprot
proteins
function
FUNCTION: Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Plays a role in preventing infection of internal organs of the urogenital system. {ECO:0000269|PubMed:15001781}.
uniprot
proteins
mass_dalton
99945
uniprot
proteins
mutagenesis
MUTAGEN 804; /note="P->H: Fails to activate NF-kappa-B."; /evidence="ECO:0000269|PubMed:15001781
uniprot
proteins
protein_family
Toll-like receptor family
uniprot
proteins
pubmed
14993594
uniprot
proteins
pubmed
15001781
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
906
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 710..730; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins