HTR2B
entrez
3357
canonical
uniprot
P41595
canonical
ensembl
ENSG00000135914
resolver
ensp
ENSP00000258400
resolver
ensp
ENSP00000560975
resolver
ensp
ENSP00000641691
resolver
ensp
ENSP00000641692
resolver
ensp
ENSP00000641694
resolver
enst
ENST00000258400
resolver
enst
ENST00000890916
resolver
enst
ENST00000971632
resolver
enst
ENST00000971633
resolver
enst
ENST00000971635
resolver
genesymbol
HTR2B
resolver
hgnc
HGNC:5294
resolver
uniprot
B2R9D5
resolver
uniprot
Q53TI1
resolver
uniprot
Q62221
resolver
uniprot
Q6P523
resolver
uniprot_entry
5HT2B_HUMAN
resolver
uniprot_sec
B2R9D5
resolver
uniprot_sec
Q53TI1
resolver
uniprot_sec
Q62221
resolver
uniprot_sec
Q6P523
resolver
amino_acid_sequence
MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:18703043, PubMed:23519210, PubMed:7926008, PubMed:8078486, PubMed:8143856, PubMed:8882600). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances (PubMed:12970106, PubMed:18703043, PubMed:23519210, PubMed:23519215, PubMed:24357322, PubMed:28129538, PubMed:30127358, PubMed:36087581, PubMed:7926008, PubMed:8078486, PubMed:8143856). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:23519215, PubMed:28129538, PubMed:8078486, PubMed:8143856, PubMed:8882600). HTR2B is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively (PubMed:18703043, PubMed:23519215, PubMed:28129538, PubMed:30127358, PubMed:36087581, PubMed:8078486, PubMed:8143856, PubMed:8882600). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:23519215, PubMed:28129538, PubMed:30127358, PubMed:36087581). Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain (By similarity). Plays a role in the regulation of behavior, including impulsive behavior (PubMed:21179162). Required for normal proliferation of embryonic cardiac myocytes and normal heart development (By similarity). Protects cardiomyocytes against apoptosis (By similarity). Plays a role in the adaptation of pulmonary arteries to chronic hypoxia (By similarity). Plays a role in vasoconstriction (By similarity). Required for normal osteoblast function and proliferation, and for maintaining normal bone density (By similarity). Required for normal proliferation of the interstitial cells of Cajal in the intestine (By similarity). {ECO:0000250|UniProtKB:Q02152, ECO:0000269|PubMed:12970106, ECO:0000269|PubMed:18703043, ECO:0000269|PubMed:21179162, ECO:0000269|PubMed:23519210, ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538, ECO:0000269|PubMed:30127358, ECO:0000269|PubMed:36087581, ECO:0000269|PubMed:7926008, ECO:0000269|PubMed:8078486, ECO:0000269|PubMed:8143856, ECO:0000269|PubMed:8882600}.
uniprot
proteins
mass_dalton
54298
uniprot
proteins
mutagenesis
MUTAGEN 132; /note="L->A: No effect on agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 135; /note="D->A: Abolishes agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 136; /note="V->A: Slightly decreases agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 139; /note="S->A: Slightly decreases agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 140; /note="T->V,A: Decreased agonist binding."; /evidence="ECO:0000269|PubMed:23519210, ECO:0000269|PubMed:30127358"; MUTAGEN 208; /note="V->A: No effect on agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 209; /note="L->A: No effect on agonist binding. Strongly increases dissociation of bound lysergic acid diethylamine, without affecting binding affinity. Reduces signaling via arrestins, but has no effect on signaling via the phosphatidylinositol-calcium second messenger system."; /evidence="ECO:0000269|PubMed:23519210, ECO:0000269|PubMed:28129538"; MUTAGEN 211; /note="K->A: Impairs protein folding and stability. Strongly reduced cell surface expression."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 217; /note="F->A: Slightly decreases agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 218; /note="M->A: No effect on agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 225; /note="A->G,S: Does not affect agonist binding."; /evidence="ECO:0000269|PubMed:23519210, ECO:0000269|PubMed:30127358"; MUTAGEN 337; /note="W->A: Slightly decreases agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 340; /note="F->A: Slightly decreases agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 344; /note="N->A: Slightly decreases agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 347; /note="L->A: No effect on agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 348; /note="V->A: No effect on agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 362; /note="L->A: No effect on agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 363; /note="E->A: No effect on agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 366; /note="V->A: No effect on agonist binding."; /evidence="ECO:0000269|PubMed:23519210"; MUTAGEN 370; /note="Y->A: Slightly decreases agonist binding."; /evidence="ECO:0000269|PubMed:23519210
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10722792
uniprot
proteins
pubmed
11150294
uniprot
proteins
pubmed
12970106
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18476671
uniprot
proteins
pubmed
18703043
uniprot
proteins
pubmed
20945968
uniprot
proteins
pubmed
21179162
uniprot
proteins
pubmed
23519210
uniprot
proteins
pubmed
23519215
uniprot
proteins
pubmed
24357322
uniprot
proteins
pubmed
28129538
uniprot
proteins
pubmed
30127358
uniprot
proteins
pubmed
36087581
uniprot
proteins
pubmed
7926008
uniprot
proteins
pubmed
8078486
uniprot
proteins
pubmed
8143856
uniprot
proteins
pubmed
8882600
uniprot
proteins
sequence_length
481
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12970106, ECO:0000269|PubMed:23519210, ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:28129538, ECO:0000269|PubMed:7926008, ECO:0000269|PubMed:8078486, ECO:0000269|PubMed:8143856}; Multi-pass membrane protein {ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q02152}.
uniprot
proteins
transmembrane_region
TRANSMEM 57..79; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538, ECO:0000269|PubMed:30127358, ECO:0000269|PubMed:36087581"; TRANSMEM 91..113; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538, ECO:0000269|PubMed:30127358, ECO:0000269|PubMed:36087581"; TRANSMEM 130..151; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538, ECO:0000269|PubMed:30127358, ECO:0000269|PubMed:36087581"; TRANSMEM 172..192; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538, ECO:0000269|PubMed:30127358, ECO:0000269|PubMed:36087581"; TRANSMEM 217..239; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538, ECO:0000269|PubMed:30127358, ECO:0000269|PubMed:36087581"; TRANSMEM 325..345; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538, ECO:0000269|PubMed:30127358, ECO:0000269|PubMed:36087581"; TRANSMEM 361..382; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:23519215, ECO:0000269|PubMed:24357322, ECO:0000269|PubMed:28129538, ECO:0000269|PubMed:30127358, ECO:0000269|PubMed:36087581
uniprot
proteins