RANBP1
entrez
5902
canonical
uniprot
P43487
canonical
ensembl
ENSG00000099901
resolver
ensp
ENSP00000327583
resolver
ensp
ENSP00000384925
resolver
ensp
ENSP00000401564
resolver
ensp
ENSP00000413502
resolver
enst
ENST00000430524
resolver
genesymbol
RANBP1
resolver
hgnc
HGNC:9847
resolver
uniprot
A0A140VK94
resolver
uniprot
B3KUP2
resolver
uniprot
B4DE76
resolver
uniprot
F6WQW2
resolver
uniprot
Q53EY3
resolver
uniprot_entry
A0A140VK94_HUMAN
resolver
uniprot_entry
B3KUP2_HUMAN
resolver
uniprot_entry
B4DE76_HUMAN
resolver
uniprot_entry
F6WQW2_HUMAN
resolver
uniprot_entry
RANG_HUMAN
resolver
uniprot_sec
Q53EY3
resolver
amino_acid_sequence
MAAAKDTHEDHDTSTENTDESNHDPQFEPIVSLPEQEIKTLEEDEEELFKMRAKLFRFASENDLPEWKERGTGDVKLLKHKEKGAIRLLMRRDKTLKICANHYITPMMELKPNAGSDRAWVWNTHADFADECPKPELLAIRFLNAENAQKFKTKFEECRKEIEEREKKAGSGKNDHAEKVAEKLEALSVKEETKEDAEEKQ
uniprot
proteins
function
FUNCTION: Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (By similarity). Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (PubMed:20485264). Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (By similarity). Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN (PubMed:17671426). Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1 (PubMed:7882974). Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (PubMed:7616957, PubMed:7882974). {ECO:0000250|UniProtKB:P34022, ECO:0000269|PubMed:17671426, ECO:0000269|PubMed:20485264, ECO:0000269|PubMed:7616957, ECO:0000269|PubMed:7882974}.
uniprot
proteins
mass_dalton
23310
uniprot
proteins
protein_family
RANBP1 family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
11832950
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
16428860
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17671426
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20485264
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
7616957
uniprot
proteins
pubmed
7882974
uniprot
proteins
pubmed
7891706
uniprot
proteins
pubmed
8896452
uniprot
proteins
sequence_length
201
uniprot
proteins