Sv2b
entrez
64176
canonical
uniprot
Q8BG39
canonical
ensembl
ENSMUSG00000053025
resolver
ensp
ENSMUSP00000082254
resolver
ensp
ENSMUSP00000127245
resolver
ensp
ENSMUSP00000146049
resolver
ensp
ENSMUSP00000282648
resolver
ensp
ENSMUSP00000282650
resolver
ensp
ENSMUSP00000282652
resolver
ensp
ENSMUSP00000282653
resolver
ensp
ENSMUSP00000282670
resolver
enst
ENSMUST00000085164
resolver
enst
ENSMUST00000165175
resolver
enst
ENSMUST00000206344
resolver
genesymbol
Sv2b
resolver
genesymbol_syn
Kiaa0735
resolver
uniprot
Q80TT1
resolver
uniprot
Q9ES95
resolver
uniprot_entry
SV2B_MOUSE
resolver
uniprot_sec
Q80TT1
resolver
uniprot_sec
Q9ES95
resolver
amino_acid_sequence
MDDYRYRDNYEGYAPSDGYYRSNEQNQEEDAQSDVTEGHDEEDEIYEGEYQGIPHPDDVKSKQTKMAPSRADGLGGQADLMAERMEDEEELAHQYETIIDECGHGRFQWTLFFVLGLALMADGVEIFVVSFALPSAEKDMCLSSSKKGMLGLIVYLGMMAGAFILGGLADKLGRKKVLSMSLAINASFASLSSFVQGYGAFLFCRLISGIGIGGSLPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGIYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPATVSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVFTVSHIKTPKQMDEFIEIQSSTGTWYQRWLVRFMTIFKQVWDNALYCVMGPYRMNTLILAVVWFTMALSYYGLTVWFPDMIRYFQDEEYKSKMKVFFGEHVHGATINFTMENQIHQHGKLVNDKFIKMYFKHVLFEDTFFDKCYFEDVTSTDTYFKNCTIESTTFYNTDLYKHKFINCRFINSTFLEQKEGCHMDFEEDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNQRATAFGILNGLCKFGAILGNTIFASFVGITKVVPILLAAASLVGGGLIALRLPETREQVLM
uniprot
proteins
function
FUNCTION: Probably plays a role in the control of regulated secretion in neural and endocrine cells. {ECO:0000305|PubMed:10624962}.; FUNCTION: (Microbial infection) Receptor for C.botulinum neurotoxin type A (BoNT/A, botA); the toxin probably binds via extracellular loop 4 (PubMed:16543415). {ECO:0000269|PubMed:16543415}.; FUNCTION: (Microbial infection) Possible receptor for C.botulinum neurotoxin type D (BoNT/D, botD) (PubMed:21483489). Not a receptor for C.botulinum neurotoxin type D (BoNT/D, botD) (PubMed:21632541). {ECO:0000269|PubMed:21632541}.; FUNCTION: (Microbial infection) Receptor for C.botulinum neurotoxin type E (BoNT/E); the toxin probably binds via extracellular loop 4 (PubMed:18815274). It probably requires glycosylation of Asn-516 (PubMed:18815274). {ECO:0000269|PubMed:18815274, ECO:0000305|PubMed:18815274}.
uniprot
proteins
mass_dalton
77457
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000305|PubMed:18815274}.; PTM: The N-terminal cytoplasmic domain is phosphorylated by CK1. {ECO:0000250}.
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
pubmed
10611374
uniprot
proteins
pubmed
10624962
uniprot
proteins
pubmed
12687700
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15466855
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16543415
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
18815274
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21483489
uniprot
proteins
pubmed
21632541
uniprot
proteins
sequence_length
683
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q63564}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q63564}. Note=Associated with synaptic-like microvesicles but not with insulin-containing vesicles in insulin-secreting cells of the pancreas (By similarity). Localizes to microvesicles in the pinealocytes. Localizes to the acrosome in spermatids (By similarity). {ECO:0000250|UniProtKB:Q63564}.
uniprot
proteins
transmembrane_region
TRANSMEM 111..131; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 149..169; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 183..203; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 206..226; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 238..258; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 278..298; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 391..411; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 536..556; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 566..586; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 593..613; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 627..649; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 654..672; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins