CHST10
entrez
9486
canonical
uniprot
O43529
canonical
ensembl
ENSG00000115526
resolver
ensp
ENSP00000264249
resolver
ensp
ENSP00000387309
resolver
ensp
ENSP00000536883
resolver
ensp
ENSP00000536884
resolver
ensp
ENSP00000536885
resolver
ensp
ENSP00000536886
resolver
ensp
ENSP00000536887
resolver
ensp
ENSP00000536888
resolver
ensp
ENSP00000536890
resolver
ensp
ENSP00000536891
resolver
ensp
ENSP00000536892
resolver
ensp
ENSP00000603626
resolver
ensp
ENSP00000603627
resolver
ensp
ENSP00000603628
resolver
ensp
ENSP00000603629
resolver
ensp
ENSP00000603630
resolver
ensp
ENSP00000603631
resolver
ensp
ENSP00000603632
resolver
ensp
ENSP00000603633
resolver
ensp
ENSP00000603634
resolver
ensp
ENSP00000642139
resolver
ensp
ENSP00000642140
resolver
ensp
ENSP00000642141
resolver
ensp
ENSP00000642143
resolver
ensp
ENSP00000642144
resolver
ensp
ENSP00000642145
resolver
ensp
ENSP00000642146
resolver
ensp
ENSP00000642147
resolver
ensp
ENSP00000642148
resolver
enst
ENST00000264249
resolver
enst
ENST00000409701
resolver
enst
ENST00000866824
resolver
enst
ENST00000866825
resolver
enst
ENST00000866826
resolver
enst
ENST00000866827
resolver
enst
ENST00000866828
resolver
enst
ENST00000866829
resolver
enst
ENST00000866831
resolver
enst
ENST00000866832
resolver
enst
ENST00000866833
resolver
enst
ENST00000933567
resolver
enst
ENST00000933568
resolver
enst
ENST00000933569
resolver
enst
ENST00000933570
resolver
enst
ENST00000933571
resolver
enst
ENST00000933572
resolver
enst
ENST00000933573
resolver
enst
ENST00000933574
resolver
enst
ENST00000933575
resolver
enst
ENST00000972080
resolver
enst
ENST00000972081
resolver
enst
ENST00000972082
resolver
enst
ENST00000972084
resolver
enst
ENST00000972085
resolver
enst
ENST00000972086
resolver
enst
ENST00000972087
resolver
enst
ENST00000972088
resolver
enst
ENST00000972089
resolver
genesymbol
CHST10
resolver
hgnc
HGNC:19650
resolver
uniprot
Q53T18
resolver
uniprot_entry
CHSTA_HUMAN
resolver
uniprot_sec
Q53T18
resolver
amino_acid_sequence
MHHQWLLLAACFWVIFMFMVASKFITLTFKDPDVYSAKQEFLFLTTMPEVRKLPEEKHIPEELKPTGKELPDSQLVQPLVYMERLELIRNVCRDDALKNLSHTPVSKFVLDRIFVCDKHKILFCQTPKVGNTQWKKVLIVLNGAFSSIEEIPENVVHDHEKNGLPRLSSFSDAEIQKRLKTYFKFFIVRDPFERLISAFKDKFVHNPRFEPWYRHEIAPGIIRKYRRNRTETRGIQFEDFVRYLGDPNHRWLDLQFGDHIIHWVTYVELCAPCEIMYSVIGHHETLEDDAPYILKEAGIDHLVSYPTIPPGITVYNRTKVEHYFLGISKRDIRRLYARFEGDFKLFGYQKPDFLLN
uniprot
proteins
ec_number
2.8.2.-
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of sulfate from 3'-phosphoadenylyl sulfate (PAPS) to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure 3-O-sulfo-beta-D-GlcA-(1->3)-beta-D-Gal-(1->4)-D-GlcNAc-R, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis (PubMed:9478973). Sulfates terminal glucuronyl residue of the laminin globular (LG)-domain binding epitope on DAG1/alpha-dystroglycan and prevents further polymerization by LARGE1 glycosyltransferase. Likely defines the chain length of LG epitope, conferring binding specificity to extracellular matrix components (PubMed:32149355). Plays a role in down-regulating the steroid hormones. Sulfates glucuronidated estrogens and androgens with an impact in hormone cycle and fertility. Has a preference for glucuronyl moiety at the 3-hydroxyl group of a sterol ring rather than the 17-hydroxyl group, showing high catalytic efficiency for 17beta-estradiol 3-O-(beta-D-glucuronate) and dehydroepiandrosterone 3-O-(beta-D-glucuronate) hormones (PubMed:23269668). {ECO:0000269|PubMed:23269668, ECO:0000269|PubMed:32149355, ECO:0000269|PubMed:9478973}.
uniprot
proteins
mass_dalton
42207
uniprot
proteins
mutagenesis
MUTAGEN 128; /note="K->A: Loss of function."; /evidence="ECO:0000269|PubMed:10464296"; MUTAGEN 128; /note="K->R: Induces a reduction in enzyme activity."; /evidence="ECO:0000269|PubMed:10464296"; MUTAGEN 189; /note="R->A,K: Loss of function."; /evidence="ECO:0000269|PubMed:10464296"; MUTAGEN 190; /note="D->A: Loss of function."; /evidence="ECO:0000269|PubMed:10464296"; MUTAGEN 190; /note="D->E: Induces a mild reduction in enzyme activity."; /evidence="ECO:0000269|PubMed:10464296"; MUTAGEN 191; /note="P->A,G: Loss of function."; /evidence="ECO:0000269|PubMed:10464296"; MUTAGEN 197; /note="S->A,T: Loss of function."; /evidence="ECO:0000269|PubMed:10464296
uniprot
proteins
pathway_participation
PATHWAY: Steroid metabolism. {ECO:0000269|PubMed:23269668}.; PATHWAY: Protein modification; carbohydrate sulfation. {ECO:0000269|PubMed:32149355}.
uniprot
proteins
protein_family
Sulfotransferase 2 family
uniprot
proteins
pubmed
10464296
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
23269668
uniprot
proteins
pubmed
32149355
uniprot
proteins
pubmed
9478973
uniprot
proteins
sequence_length
356
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:O54702}; Single-pass type II membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..27; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins