SLC25A2
entrez
83884
canonical
uniprot
Q9BXI2
canonical
ensembl
ENSG00000120329
resolver
ensp
ENSP00000239451
resolver
enst
ENST00000239451
resolver
genesymbol
SLC25A2
resolver
genesymbol_syn
ORC2
resolver
genesymbol_syn
ORNT2
resolver
hgnc
HGNC:22921
resolver
uniprot
Q496C1
resolver
uniprot
Q6XUI0
resolver
uniprot
Q8NFZ2
resolver
uniprot_entry
ORNT2_HUMAN
resolver
uniprot_sec
Q496C1
resolver
uniprot_sec
Q6XUI0
resolver
uniprot_sec
Q8NFZ2
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by pyridoxal 5'-phosphate, N-ethylmaleimide, spermine and spermidine. {ECO:0000269|PubMed:12807890}.
uniprot
proteins
amino_acid_sequence
MKSGPGIQAAIDLTAGAAGGTACVLTGQPFDTIKVKMQTFPDLYKGLTDCFLKTYAQVGLRGFYKGTGPALMAYVAENSVLFMCYGFCQQFVRKVAGMDKQAKLSDLQTAAAGSFASAFAALALCPTELVKCRLQTMYEMEMSGKIAKSHNTIWSVVKGILKKDGPLGFYHGLSSTLLQEVPGYFFFFGGYELSRSFFASGRSKDELGPVHLMLSGGVAGICLWLVVFPVDCIKSRIQVLSMYGKQAGFIGTLLSVVRNEGIVALYSGLKATMIRAIPANGALFVAYEYSRKMMMKQLEAY
uniprot
proteins
function
FUNCTION: Mitochondrial transporter of the positively charged amino acids ornithine, lysine and arginine, and the neutral amino acid citrulline (PubMed:12807890). In addition, transports the basic amino acids histidine, homoarginine, and asymmetric dimethylarginine (aDMA), but not symmetric DMA, and the D-forms of lysine, arginine, ornithine and histidine (PubMed:12807890, PubMed:26403849). Functions by both counter-exchange and uniport mechanisms (PubMed:26403849). {ECO:0000269|PubMed:12807890, ECO:0000269|PubMed:26403849}.
uniprot
proteins
mass_dalton
32580
uniprot
proteins
mutagenesis
MUTAGEN 74; /note="Y->N: Does not significantly change the substrate specificity."; /evidence="ECO:0000269|PubMed:22262851"; MUTAGEN 179; /note="Q->H: Does not significantly change the substrate specificity."; /evidence="ECO:0000269|PubMed:22262851"; MUTAGEN 179; /note="Q->K: Does not significantly change the substrate specificity."; /evidence="ECO:0000269|PubMed:22262851"; MUTAGEN 179; /note="Q->N: Does not significantly change the substrate specificity."; /evidence="ECO:0000269|PubMed:22262851"; MUTAGEN 179; /note="Q->R: Ornithine homo-exchange is enhanced 18-fold. Vmax value 33-fold higher than wild-type."; /evidence="ECO:0000269|PubMed:22262851, ECO:0000269|PubMed:26403849
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
11230163
uniprot
proteins
pubmed
12807890
uniprot
proteins
pubmed
12948741
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22262851
uniprot
proteins
pubmed
26403849
uniprot
proteins
sequence_length
301
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:12948741}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion inner membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..25; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 68..88; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 110..130; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 168..188; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 210..230; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 237..257; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins