DLG4
entrez
1742
canonical
uniprot
P78352
canonical
ensembl
ENSG00000132535
resolver
ensp
ENSP00000307471
resolver
ensp
ENSP00000382425
resolver
ensp
ENSP00000382428
resolver
ensp
ENSP00000497011
resolver
ensp
ENSP00000497647
resolver
ensp
ENSP00000497806
resolver
ensp
ENSP00000497879
resolver
enst
ENST00000399510
resolver
enst
ENST00000649186
resolver
enst
ENST00000649520
resolver
enst
ENST00000649971
resolver
genesymbol
DLG4
resolver
genesymbol_syn
PSD95
resolver
hgnc
HGNC:2903
resolver
uniprot
A0A3B3IS17
resolver
uniprot
A0A3B3ITG0
resolver
uniprot
A0A3F2YNY9
resolver
uniprot
B7Z1S1
resolver
uniprot
B7Z4H2
resolver
uniprot
B7Z647
resolver
uniprot
B9EGL1
resolver
uniprot
G5E939
resolver
uniprot
Q92941
resolver
uniprot
Q9UKK8
resolver
uniprot_entry
A0A3B3IS17_HUMAN
resolver
uniprot_entry
A0A3B3ITG0_HUMAN
resolver
uniprot_entry
A0A3F2YNY9_HUMAN
resolver
uniprot_entry
B7Z4H2_HUMAN
resolver
uniprot_entry
B7Z647_HUMAN
resolver
uniprot_entry
B9EGL1_HUMAN
resolver
uniprot_entry
DLG4_HUMAN
resolver
uniprot_sec
B7Z1S1
resolver
uniprot_sec
G5E939
resolver
uniprot_sec
Q92941
resolver
uniprot_sec
Q9UKK8
resolver
amino_acid_sequence
MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL
uniprot
proteins
disease_involvement
DISEASE: Intellectual developmental disorder, autosomal dominant 62 (MRD62) [MIM:618793]: An autosomal dominant form of intellectual disability, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD62 is characterized by mild to moderately impaired intellectual development. {ECO:0000269|PubMed:27479843, ECO:0000269|PubMed:29460436}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins. Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B. Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (By similarity). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins (PubMed:26334723). {ECO:0000250|UniProtKB:Q62108, ECO:0000269|PubMed:26334723}.
uniprot
proteins
mass_dalton
80495
uniprot
proteins
post_translational_modification
PTM: Palmitoylated (PubMed:26701913). Palmitoylation is required for targeting to postsynaptic density, plasma membrane and synapses (By similarity). Palmitoylation by ZDHHC2 occurs when the synaptic activity decreases and induces DLG4 synaptic clustering (By similarity). Palmitoylation by ZDHHC15 regulates trafficking to the postsynaptic density and function in synaptogenesis (By similarity). Palmitoylation may play a role in glutamate receptor GRIA1 synapse clustering (By similarity). Depalmitoylated by ABHD17A and ABHD17B and to a lesser extent by ABHD17C, ABHD12, ABHD13, LYPLA1 and LYPLA2 (PubMed:26701913). Undergoes rapid synaptic palmitoylation/depalmitoylation cycles during neuronal development which slow down in mature neurons (By similarity). {ECO:0000250|UniProtKB:P31016, ECO:0000269|PubMed:26701913}.; PTM: Ubiquitinated by MDM2 in response to NMDA receptor activation, leading to proteasome-mediated degradation of DLG4 which is required for AMPA receptor endocytosis. {ECO:0000250|UniProtKB:P31016}.
uniprot
proteins
protein_family
MAGUK family
uniprot
proteins
pubmed
10582582
uniprot
proteins
pubmed
10725395
uniprot
proteins
pubmed
10859302
uniprot
proteins
pubmed
11744724
uniprot
proteins
pubmed
12151521
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16630835
uniprot
proteins
pubmed
19118189
uniprot
proteins
pubmed
20962234
uniprot
proteins
pubmed
21119615
uniprot
proteins
pubmed
23782696
uniprot
proteins
pubmed
25780553
uniprot
proteins
pubmed
26334723
uniprot
proteins
pubmed
26701913
uniprot
proteins
pubmed
27009485
uniprot
proteins
pubmed
27066583
uniprot
proteins
pubmed
27479843
uniprot
proteins
pubmed
29460436
uniprot
proteins
pubmed
7477295
uniprot
proteins
pubmed
9278515
uniprot
proteins
pubmed
9286702
uniprot
proteins
sequence_length
724
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12151521}; Lipid-anchor {ECO:0000269|PubMed:12151521}; Cytoplasmic side {ECO:0000269|PubMed:12151521}. Postsynaptic density {ECO:0000250|UniProtKB:P31016}. Synapse {ECO:0000269|PubMed:12151521}. Cytoplasm {ECO:0000250|UniProtKB:P31016}. Cell projection, axon {ECO:0000250|UniProtKB:P31016}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:P31016}. Cell projection, dendrite {ECO:0000250|UniProtKB:P31016}. Presynapse {ECO:0000250|UniProtKB:P31016}. Note=High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells. Suppression of neuronal activity induces synaptic accumulation and clustering of DLG4. {ECO:0000250|UniProtKB:P31016}.
uniprot
proteins