HMHB1
entrez
57824
canonical
uniprot
O97980
canonical
ensembl
ENSG00000158497
resolver
ensp
ENSP00000289448
resolver
enst
ENST00000289448
resolver
genesymbol
HMHB1
resolver
hgnc
HGNC:29677
resolver
uniprot
Q9MY25
resolver
uniprot_entry
HMHB1_HUMAN
resolver
uniprot_sec
Q9MY25
resolver
amino_acid_sequence
MEEQPECREEKRGSLHVWKSELVEVEDDVYLRHSSSLTYRL
uniprot
proteins
function
FUNCTION: Precursor of the histocompatibility antigen HB-1. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HB-1 is presented on the cell surface by MHC class I HLA-B44. This complex specifically elicits donor-cytotoxic T lymphocyte (CTL) reactivity in B-cell acute lymphoblastic leukemia (B-ALL) after treatment by HLA-identical allogenic bone marrow transplantation (BMT). It induces cell recognition and lysis by CTL. However, HB-1 restricted expression in B-ALL cells and not in normal tissues may allow a specific CTL reactivity against B-ALL without the risk of evoking graft-versus-host disease. {ECO:0000269|PubMed:15102363, ECO:0000269|PubMed:8992968, ECO:0000269|PubMed:9892612}.
uniprot
proteins
mass_dalton
4965
uniprot
proteins
mutagenesis
MUTAGEN 9; /note="E->A: Decreased CTL recognition."; /evidence="ECO:0000269|PubMed:12355426"; MUTAGEN 10; /note="E->A: Decreased CTL recognition."; /evidence="ECO:0000269|PubMed:12355426"; MUTAGEN 11; /note="K->A: Complete loss of CTL recognition."; /evidence="ECO:0000269|PubMed:12355426"; MUTAGEN 12; /note="R->A: Complete loss of CTL recognition."; /evidence="ECO:0000269|PubMed:12355426"; MUTAGEN 13; /note="G->A: Complete loss of CTL recognition."; /evidence="ECO:0000269|PubMed:12355426"; MUTAGEN 14; /note="S->A: Complete loss of CTL recognition."; /evidence="ECO:0000269|PubMed:12355426"; MUTAGEN 15; /note="L->A: Complete loss of CTL recognition."; /evidence="ECO:0000269|PubMed:12355426"; MUTAGEN 16; /note="H->A: Complete loss of CTL recognition."; /evidence="ECO:0000269|PubMed:12355426"; MUTAGEN 16; /note="H->R: CTL recognition."; /evidence="ECO:0000269|PubMed:12355426"; MUTAGEN 17; /note="V->A: Decreased CTL recognition."; /evidence="ECO:0000269|PubMed:12355426"; MUTAGEN 18; /note="W->A: Complete loss of CTL recognition."; /evidence="ECO:0000269|PubMed:12355426
uniprot
proteins
pubmed
12355426
uniprot
proteins
pubmed
15102363
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8992968
uniprot
proteins
pubmed
9892612
uniprot
proteins
sequence_length
41
uniprot
proteins