C2
entrez
12263
canonical
uniprot
P21180
canonical
ensembl
ENSMUSG00000024371
resolver
ensp
ENSMUSP00000025230
resolver
genesymbol
C2
resolver
uniprot
O70350
resolver
uniprot_entry
CO2_MOUSE
resolver
uniprot_sec
O70350
resolver
amino_acid_sequence
MAPLLALFYLLQLGPGLAALFCNQNVNITGGNFTLSHGWAPGSLLIYSCPLGRYPSPAWRKCQSNGQWLTPRSSSHHTLRSSRMVKAVCKPVRCLAPSSFENGIYFPRLVSYPVGSNVSFECEQDFTLRGSPVRYCRPNGLWDGETAVCDNGASHCPNPGISVGTARTGLNFDLGDKVRYRCSSSNMVLTGSAERECQSNGVWSGSEPICRQPYSYDFPEDVASALDTSLTNLLGATNPTQNLLTKSLGRKIIIQRSGHLNLYLLLDASQSVTEKDFDIFKKSAELMVERIFSFEVNVSVAIITFASQPKTIMSILSERSQDVTEVITSLDSASYKDHENATGTNTYEVLIRVYSMMQSQMDRLGMETSAWKEIRHTIILLTDGKSNMGDSPKKAVTRIRELLSIEQNRDDYLDIYAIGVGKLDVDWKELNELGSKKDGERHAFILQDAKALQQIFEHMLDVSKLTDTICGVGNMSANASDQERTPWQVTFKPKSKETCQGSLISDQWVLTAAHCFHDIQMEDHHLWRVNVGDPTSQHGKEFLVEDVIIAPGFNVHAKRKQGISEFYADDIALLKLSRKVKMSTHARPICLPCTVGANMALRRSPGSTCKDHETELLSQQKVPAHFVALNGNRLNINLRTGPEWTRCIQAVSQNKNIFPSLTNVSEVVTDQFLCSGMEEEDDNPCKGESGGAVFLGRRYRFFQVGLVSWGLFDPCHGSSNKNLRKKPPRGVLPRDFHISLFRLQPWLRQHLDGVLDFLPL
uniprot
proteins
ec_number
3.4.21.43
uniprot
proteins
function
FUNCTION: Precursor of the catalytic component of the C3 and C5 convertase complexes, which are part of the complement pathway, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Component C2 is part of the classical, lectin and GZMK complement systems. {ECO:0000250|UniProtKB:P06681}.; FUNCTION: [Serine protease complement C2b]: Catalytic component of the complement C3 and C5 convertase complexes. Following complement activation, recruited to the surface of pathogens by complement C4b opsonin to form the C3 convertase, or C3b and C4b opsonins to form the C5 convertase. As part of the C3 convertase, cleaves and activate C3 into C3a anaphylatoxin and C3b opsonin, the next components of the complement pathways. As part of the C5 convertase, cleaves and activate C5 into C5a anaphylatoxin and C5b component of the membrane attack complex. {ECO:0000250|UniProtKB:P06681}.
uniprot
proteins
mass_dalton
84741
uniprot
proteins
post_translational_modification
PTM: Cleaved and activated by different proteases depending on the complement pathway to generate complement C2a and serine protease complement C2b chains. Cleaved and activated by C1S following activation by the classical complement system. Cleaved and activated by MASP2 following activation by the lectin complement system. Cleaved and activated by GZMK following activation by the GZMK complement system. {ECO:0000250|UniProtKB:P06681}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
14656967
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2229060
uniprot
proteins
sequence_length
760
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P06681}. Cell surface {ECO:0000250|UniProtKB:P06681}. Note=Recruited to the surface of pathogens by complement C3b and complement C4b opsonins. {ECO:0000250|UniProtKB:P06681}.
uniprot
proteins