FLOT2
entrez
2319
canonical
uniprot
Q14254
canonical
ensembl
ENSG00000132589
resolver
ensp
ENSP00000378368
resolver
ensp
ENSP00000463503
resolver
enst
ENST00000394908
resolver
enst
ENST00000585169
resolver
genesymbol
FLOT2
resolver
genesymbol_syn
ESA1
resolver
genesymbol_syn
M17S1
resolver
hgnc
HGNC:3758
resolver
uniprot
J3QLD9
resolver
uniprot
Q6FG43
resolver
uniprot
Q9BTI6
resolver
uniprot_entry
FLOT2_HUMAN
resolver
uniprot_entry
J3QLD9_HUMAN
resolver
uniprot_entry
Q6FG43_HUMAN
resolver
uniprot_entry
Q9BTI6_HUMAN
resolver
amino_acid_sequence
MGNCHTVGPNEALVVSGGCCGSDYKQYVFGGWAWAWWCISDTQRISLEIMTLQPRCEDVETAEGVALTVTGVAQVKIMTEKELLAVACEQFLGKNVQDIKNVVLQTLEGHLRSILGTLTVEQIYQDRDQFAKLVREVAAPDVGRMGIEILSFTIKDVYDKVDYLSSLGKTQTAVVQRDADIGVAEAERDAGIREAECKKEMLDVKFMADTKIADSKRAFELQKSAFSEEVNIKTAEAQLAYELQGAREQQKIRQEEIEIEVVQRKKQIAVEAQEILRTDKELIATVRRPAEAEAHRIQQIAEGEKVKQVLLAQAEAEKIRKIGEAEAAVIEAMGKAEAERMKLKAEAYQKYGDAAKMALVLEALPQIAAKIAAPLTKVDEIVVLSGDNSKVTSEVNRLLAELPASVHALTGVDLSKIPLIKKATGVQV
uniprot
proteins
function
FUNCTION: May act as a scaffolding protein within caveolar membranes, functionally participating in formation of caveolae or caveolae-like vesicles. May be involved in epidermal cell adhesion and epidermal structure and function.
uniprot
proteins
mass_dalton
47064
uniprot
proteins
mutagenesis
MUTAGEN 4; /note="C->S: Loss of ZDHHC5-catalyzed palmitoylation; when associated with S-20. Partial loss of ZDHHC5-catalyzed palmitoylation; when associated with S-19. Complete loss of palmitoylation; when associated with S-19 and S-20."; /evidence="ECO:0000269|PubMed:22081607"; MUTAGEN 19; /note="C->S: Partial loss of ZDHHC5-catalyzed palmitoylation; when associated with S-4 or S-20. Complete loss of palmitoylation; when associated with S-4 and S-20."; /evidence="ECO:0000269|PubMed:22081607"; MUTAGEN 20; /note="C->S: Loss of ZDHHC5-catalyzed palmitoylation; when associated with S-4. Partial loss of ZDHHC5-catalyzed palmitoylation; when associated with S-19. Complete loss of palmitoylation; when associated with S-4 and S-19."; /evidence="ECO:0000269|PubMed:22081607
uniprot
proteins
post_translational_modification
PTM: ZDHHC5-catalyzed palmitoylation predominantly occurs at Cys-4. ZDHHC5-catalyzed palmitoylation may be required for the formation of higher-order complexes and for neurite outgrowth in cultured neural stem cells. {ECO:0000269|PubMed:22081607}.
uniprot
proteins
protein_family
Band 7/mec-2 family
uniprot
proteins
protein_family
Flotillin subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
20682791
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22081607
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25255805
uniprot
proteins
pubmed
8051082
uniprot
proteins
sequence_length
428
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20682791}; Peripheral membrane protein {ECO:0000269|PubMed:20682791}. Membrane, caveola {ECO:0000269|PubMed:20682791}; Peripheral membrane protein {ECO:0000269|PubMed:20682791}. Endosome {ECO:0000269|PubMed:20682791}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Note=Membrane-associated protein of caveolae.
uniprot
proteins