Tmed1
entrez
17083
canonical
uniprot
Q3V009
canonical
ensembl
ENSMUSG00000032180
resolver
ensp
ENSMUSP00000034698
resolver
genesymbol
Tmed1
resolver
genesymbol_syn
Il1rl1l
resolver
uniprot
B2RRM5
resolver
uniprot
Q3TUX8
resolver
uniprot
Q61073
resolver
uniprot
Q91YK3
resolver
uniprot_entry
B2RRM5_MOUSE
resolver
uniprot_entry
TMED1_MOUSE
resolver
uniprot_sec
Q3TUX8
resolver
uniprot_sec
Q61073
resolver
uniprot_sec
Q91YK3
resolver
amino_acid_sequence
MMAAGAAVALALWLLLPAVGVGEAGPPPIQDGEFTFLLPAGRKQCFYQSAPANASLETEYQVIGGAGLDVDFTLESPQGVLLVSESRKADGVHTVEPTEAGDYRLCFDNSFSTISEKLVFFELIFDSFQDEEEVEGWAEAVEPEEMLDVKMEDIKESIETMRTRLERSIQMLTLLRAFEARDRNLQEDNLERVNFWSAANVAVLLLVAVLQVCTLKRFFHDKRPVPT
uniprot
proteins
function
FUNCTION: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. Plays a positive role in IL-33-mediated IL-8 and IL-6 production by interacting with interleukin-33 receptor IL1RL1. Plays also a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26. {ECO:0000250|UniProtKB:Q13445}.
uniprot
proteins
mass_dalton
25263
uniprot
proteins
protein_family
EMP24/GP25L family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8621446
uniprot
proteins
sequence_length
227
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q13445}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q13445}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q13445}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:Q13445}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 195..215; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins