POLR1E
entrez
64425
canonical
uniprot
Q9GZS1
canonical
ensembl
ENSG00000137054
resolver
ensp
ENSP00000367023
resolver
ensp
ENSP00000367029
resolver
genesymbol
POLR1E
resolver
genesymbol_syn
PAF53
resolver
genesymbol_syn
PRAF1
resolver
hgnc
HGNC:17631
resolver
uniprot
B4E005
resolver
uniprot
Q5VZT3
resolver
uniprot
Q8NBA9
resolver
uniprot
Q96L20
resolver
uniprot_entry
B4E005_HUMAN
resolver
uniprot_entry
RPA49_HUMAN
resolver
uniprot_sec
Q5VZT3
resolver
uniprot_sec
Q8NBA9
resolver
uniprot_sec
Q96L20
resolver
amino_acid_sequence
MAAEVLPSARWQYCGAPDGSQRAVLVQFSNGKLQSPGNMRFTLYENKDSTNPRKRNQRILAAETDRLSYVGNNFGTGALKCNTLCRHFVGILNKTSGQMEVYDAELFNMQPLFSDVSVESELALESQTKTYREKMDSCIEAFGTTKQKRALNTRRMNRVGNESLNRAVAKAAETIIDTKGVTALVSDAIHNDLQDDSLYLPPCYDDAAKPEDVYKFEDLLSPAEYEALQSPSEAFRNVTSEEILKMIEENSHCTFVIEALKSLPSDVESRDRQARCIWFLDTLIKFRAHRVVKRKSALGPGVPHIINTKLLKHFTCLTYNNGRLRNLISDSMKAKITAYVIILALHIHDFQIDLTVLQRDLKLSEKRMMEIAKAMRLKISKRRVSVAAGSEEDHKLGTLSLPLPPAQTSDRLAKRRKIT
uniprot
proteins
function
FUNCTION: Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates (PubMed:24207024, PubMed:34671025, PubMed:34887565, PubMed:36271492). Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF (PubMed:24207024). {ECO:0000269|PubMed:24207024, ECO:0000269|PubMed:34671025, ECO:0000269|PubMed:34887565, ECO:0000269|PubMed:36271492}.
uniprot
proteins
mass_dalton
47260
uniprot
proteins
mutagenesis
MUTAGEN 373; /note="K->R: Decreased acetylation."; /evidence="ECO:0000269|PubMed:24207024
uniprot
proteins
post_translational_modification
PTM: Acetylated at Lys-373 by CREBBP/CBP, leading to decreased RNA polymerase I transcription (PubMed:24207024). In normal conditions, deacetylated by SIRT7, promoting the association of RNA polymerase I with the rDNA promoter region and coding region (PubMed:24207024). In response to stress, SIRT7 is released from nucleoli leading to hyperacetylation of POLR1E/PAF53 and decreased association of RNA polymerase I with the rDNA promoter region (PubMed:24207024). {ECO:0000269|PubMed:24207024}.
uniprot
proteins
protein_family
Eukaryotic RPA49/POLR1E RNA polymerase subunit family
uniprot
proteins
pubmed
12429849
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16809778
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24207024
uniprot
proteins
pubmed
29065309
uniprot
proteins
pubmed
34671025
uniprot
proteins
pubmed
34887565
uniprot
proteins
pubmed
36271492
uniprot
proteins
sequence_length
419
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:24207024}.
uniprot
proteins