Psma3
entrez
29670
canonical
uniprot
P18422
canonical
ensembl
ENSRNOG00000007851
resolver
ensembl
ENSRNOG00055009458
resolver
ensembl
ENSRNOG00060006748
resolver
ensembl
ENSRNOG00065007205
resolver
ensp
ENSRNOP00000084525
resolver
ensp
ENSRNOP00055012856
resolver
ensp
ENSRNOP00060008290
resolver
ensp
ENSRNOP00065008217
resolver
enst
ENSRNOT00000105733
resolver
enst
ENSRNOT00055016021
resolver
enst
ENSRNOT00060011098
resolver
enst
ENSRNOT00065011258
resolver
genesymbol
Psma3
resolver
uniprot_entry
PSA3_RAT
resolver
amino_acid_sequence
MSSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTCRDVVKEVAKIIYIVHDEVKDKAFELELSWVGELTKGRHEIVPKDVREEAEKYAKESLKEEDESDDDNM
uniprot
proteins
function
FUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2. {ECO:0000250|UniProtKB:P25788}.
uniprot
proteins
mass_dalton
28419
uniprot
proteins
protein_family
Peptidase T1A family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
2249692
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2335242
uniprot
proteins
pubmed
2403356
uniprot
proteins
sequence_length
255
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P25788}. Nucleus {ECO:0000250|UniProtKB:P25788}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000250|UniProtKB:P25788}.
uniprot
proteins