Leprot
entrez
230514
canonical
uniprot
O89013
canonical
ensembl
ENSMUSG00000035212
resolver
ensp
ENSMUSP00000030254
resolver
ensp
ENSMUSP00000102540
resolver
genesymbol
Leprot
resolver
genesymbol_syn
Lepr
resolver
genesymbol_syn
Obr
resolver
uniprot
A2AV64
resolver
uniprot
Q3TGT4
resolver
uniprot
Q3TWZ2
resolver
uniprot
Q545G9
resolver
uniprot
Q91Z23
resolver
uniprot_entry
OBRG_MOUSE
resolver
uniprot_sec
A2AV64
resolver
uniprot_sec
Q3TGT4
resolver
uniprot_sec
Q3TWZ2
resolver
uniprot_sec
Q545G9
resolver
uniprot_sec
Q91Z23
resolver
amino_acid_sequence
MAGVKALVALSFSGAIGLTFLMLGCALEDYGVYWPLFVLIFYVISPIPYFIAKRVTYDSDATSSACRELAYFFTTGIVVSAFGLPVVLARVDVIKWGACGLVLAGNAVIFLTIQGFFLVFGRGDDFSWEQW
uniprot
proteins
function
FUNCTION: Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. {ECO:0000269|PubMed:18042720, ECO:0000269|PubMed:19907080}.
uniprot
proteins
mass_dalton
14316
uniprot
proteins
protein_family
OB-RGRP/VPS55 family
uniprot
proteins
pubmed
10849209
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18042720
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19907080
uniprot
proteins
pubmed
9207021
uniprot
proteins
sequence_length
131
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:18042720}; Multi-pass membrane protein {ECO:0000269|PubMed:18042720}. Endosome membrane {ECO:0000269|PubMed:18042720}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..27; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 32..52; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 69..89; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 100..120; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins