Ackr3
entrez
84348
canonical
uniprot
O89039
canonical
ensembl
ENSRNOG00000019622
resolver
ensembl
ENSRNOG00055010155
resolver
ensembl
ENSRNOG00060010605
resolver
ensembl
ENSRNOG00065019894
resolver
ensp
ENSRNOP00000088201
resolver
ensp
ENSRNOP00000094961
resolver
ensp
ENSRNOP00055013784
resolver
ensp
ENSRNOP00055013787
resolver
ensp
ENSRNOP00055013789
resolver
ensp
ENSRNOP00055013796
resolver
ensp
ENSRNOP00055013797
resolver
ensp
ENSRNOP00060013949
resolver
ensp
ENSRNOP00060013953
resolver
ensp
ENSRNOP00060013961
resolver
ensp
ENSRNOP00060013963
resolver
ensp
ENSRNOP00060013964
resolver
ensp
ENSRNOP00065026799
resolver
ensp
ENSRNOP00065026806
resolver
ensp
ENSRNOP00065026809
resolver
ensp
ENSRNOP00065026824
resolver
ensp
ENSRNOP00065026833
resolver
enst
ENSRNOT00000108608
resolver
enst
ENSRNOT00000113813
resolver
enst
ENSRNOT00055017132
resolver
enst
ENSRNOT00055017135
resolver
enst
ENSRNOT00055017137
resolver
enst
ENSRNOT00055017144
resolver
enst
ENSRNOT00055017145
resolver
enst
ENSRNOT00060017945
resolver
enst
ENSRNOT00060017948
resolver
enst
ENSRNOT00060017956
resolver
enst
ENSRNOT00060017958
resolver
enst
ENSRNOT00060017959
resolver
enst
ENSRNOT00065033508
resolver
enst
ENSRNOT00065033514
resolver
enst
ENSRNOT00065033517
resolver
enst
ENSRNOT00065033532
resolver
enst
ENSRNOT00065033543
resolver
genesymbol
Ackr3
resolver
genesymbol_syn
Cmkor1
resolver
genesymbol_syn
Cxcr7
resolver
genesymbol_syn
Rdc1
resolver
uniprot
Q9JLZ0
resolver
uniprot_entry
ACKR3_RAT
resolver
uniprot_sec
Q9JLZ0
resolver
amino_acid_sequence
MDVHLFDYVEPGNYSDINWPCNSSDCIVVDTVQCPAMPNKNVLLYTLSFIYIFIFVIGMIANSVVVWVNIQAKTTGYDTHCYILNLAIADLWVVITIPVWVVSLVQHNQWPMGELTCKITHLIFSINLFGSIFFLACMSVDRYLSITYFTSTSSYKKKMVRRVVCVLVWLLAFFVSLPDTYYLKTVTSASNNETYCRSFYPEHSIKEWLIGMELVSVILGFAVPFTIIAIFYFLLARAMSASGDQEKHSSRKIIFSYVVVFLVCWLPYHFVVLLDIFSILHYIPFTCQLENVLFTALHVTQCLSLVHCCVNPVLYSFINRNYRYELMKAFIFKYSAKTGLTKLIDASRVSETEYSALEQNTK
uniprot
proteins
function
FUNCTION: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. {ECO:0000269|PubMed:20018651}.; FUNCTION: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1 (By similarity). Chemokine binding does not activate G protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway (PubMed:20018651). Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Regulates axon guidance in the oculomotor system through the regulation of CXCL12 levels (By similarity). Acts as a receptor for SHLP2, mediating its effects on activation of proopiomelanocortin neurons in the arcuate nucleus of the hypothalamus which leads to suppression of food intake and increased energy expenditure (By similarity). {ECO:0000250|UniProtKB:P25106, ECO:0000269|PubMed:20018651}.
uniprot
proteins
mass_dalton
41650
uniprot
proteins
post_translational_modification
PTM: The Ser/Thr residues in the C-terminal cytoplasmic tail may be phosphorylated. {ECO:0000250|UniProtKB:P25106}.; PTM: Ubiquitinated at the Lys residues in its C-terminal cytoplasmic tail and is essential for correct trafficking from and to the cell membrane. Deubiquitinated by CXCL12-stimulation in a reversible manner. {ECO:0000250|UniProtKB:P25106}.
uniprot
proteins
protein_family
Atypical chemokine receptor subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
18513805
uniprot
proteins
pubmed
18615560
uniprot
proteins
pubmed
20018651
uniprot
proteins
pubmed
21655198
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
362
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21655198}; Multi-pass membrane protein {ECO:0000269|PubMed:21655198}. Early endosome {ECO:0000305|PubMed:21655198}. Recycling endosome {ECO:0000305|PubMed:21655198}. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via clathrin-coated pits in a beta-arrestin -dependent manner. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane (By similarity). {ECO:0000250|UniProtKB:P25106}.
uniprot
proteins
transmembrane_region
TRANSMEM 48..68; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 82..102; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 119..139; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 163..183; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 214..234; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 253..273; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 297..319; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins