LYPD6
entrez
130574
canonical
uniprot
Q86Y78
canonical
ensembl
ENSG00000187123
resolver
ensp
ENSP00000334463
resolver
ensp
ENSP00000386413
resolver
genesymbol
LYPD6
resolver
hgnc
HGNC:28751
resolver
uniprot
B3KWC0
resolver
uniprot
Q4G121
resolver
uniprot
Q53TR3
resolver
uniprot
Q659B1
resolver
uniprot_entry
LYPD6_HUMAN
resolver
uniprot_sec
B3KWC0
resolver
uniprot_sec
Q4G121
resolver
uniprot_sec
Q53TR3
resolver
uniprot_sec
Q659B1
resolver
amino_acid_sequence
MEPGPALAWLLLLSLLADCLKAAQSRDFTVKDIIYLHPSTTPYPGGFKCFTCEKAADNYECNRWAPDIYCPRETRYCYTQHTMEVTGNSISVTKRCVPLEECLSTGCRDSEHEGHKVCTSCCEGNICNLPLPRNETDATFATTSPINQTNGHPRCMSVIVSCLWLWLGLML
uniprot
proteins
function
FUNCTION: Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain (PubMed:27344019, PubMed:34631692). Inhibits nicotine-induced Ca(2+) influx through nAChRs (PubMed:27344019). In vitro, specifically inhibits alpha-3:beta-4 and alpha-7 nAChR currents in an allosteric manner (PubMed:34631692). Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity). {ECO:0000250|UniProtKB:Q66IA6, ECO:0000269|PubMed:27344019, ECO:0000269|PubMed:34631692}.
uniprot
proteins
mass_dalton
19118
uniprot
proteins
mutagenesis
MUTAGEN 83..92; /note="MEVTGNSISV->FTLLPNAISI: Able to bind to LRP6."; /evidence="ECO:0000269|PubMed:30069874"; MUTAGEN 88; /note="N->A: Abolishes binding to LRP6."; /evidence="ECO:0000269|PubMed:30069874"; MUTAGEN 90; /note="I->E: Severely reduces binding to LRP6."; /evidence="ECO:0000269|PubMed:30069874"; MUTAGEN 111; /note="E->R: Increased binding to LRP6."; /evidence="ECO:0000269|PubMed:30069874
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19653121
uniprot
proteins
pubmed
25680266
uniprot
proteins
pubmed
27344019
uniprot
proteins
pubmed
30069874
uniprot
proteins
pubmed
33019770
uniprot
proteins
pubmed
34631692
uniprot
proteins
sequence_length
171
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:19653121}. Cell membrane {ECO:0000269|PubMed:25680266}; Lipid-anchor, GPI-anchor {ECO:0000255}. Synapse, synaptosome {ECO:0000250|UniProtKB:D3ZTT2}. Membrane raft {ECO:0000250|UniProtKB:Q66IA6}. Cell projection, dendrite {ECO:0000250|UniProtKB:D3ZTT2}. Perikaryon {ECO:0000250|UniProtKB:D3ZTT2}. Note=Colocalizes with alpha-3:beta-4- and alpha-7- nicotinic acetylcholine receptors (nAChRs) in the primary cortex and hippocampus. {ECO:0000250|UniProtKB:D3ZTT2}.
uniprot
proteins