OPLAH
entrez
26873
canonical
uniprot
O14841
canonical
ensembl
ENSG00000178814
resolver
ensp
ENSP00000480476
resolver
ensp
ENSP00000565012
resolver
ensp
ENSP00000565013
resolver
ensp
ENSP00000565014
resolver
ensp
ENSP00000565015
resolver
ensp
ENSP00000565016
resolver
ensp
ENSP00000565017
resolver
ensp
ENSP00000565018
resolver
ensp
ENSP00000565019
resolver
ensp
ENSP00000565020
resolver
ensp
ENSP00000641727
resolver
ensp
ENSP00000641728
resolver
ensp
ENSP00000641729
resolver
ensp
ENSP00000641730
resolver
ensp
ENSP00000641731
resolver
ensp
ENSP00000641733
resolver
ensp
ENSP00000641735
resolver
ensp
ENSP00000641737
resolver
ensp
ENSP00000641738
resolver
ensp
ENSP00000666778
resolver
enst
ENST00000618853
resolver
enst
ENST00000894953
resolver
enst
ENST00000894954
resolver
enst
ENST00000894955
resolver
enst
ENST00000894956
resolver
enst
ENST00000894957
resolver
enst
ENST00000894958
resolver
enst
ENST00000894959
resolver
enst
ENST00000894960
resolver
enst
ENST00000894961
resolver
enst
ENST00000971668
resolver
enst
ENST00000971669
resolver
enst
ENST00000971670
resolver
enst
ENST00000971671
resolver
enst
ENST00000971672
resolver
enst
ENST00000971674
resolver
enst
ENST00000971676
resolver
enst
ENST00000971678
resolver
enst
ENST00000971679
resolver
genesymbol
OPLAH
resolver
hgnc
HGNC:8149
resolver
uniprot
A5PKY8
resolver
uniprot
Q75W65
resolver
uniprot
Q9Y4Q0
resolver
uniprot_entry
OPLA_HUMAN
resolver
uniprot_sec
A5PKY8
resolver
uniprot_sec
Q75W65
resolver
uniprot_sec
Q9Y4Q0
resolver
amino_acid_sequence
MGSPEGRFHFAIDRGGTFTDVFAQCPGGHVRVLKLLSEDPANYADAPTEGIRRILEQEAGMLLPRDQPLDSSHIASIRMGTTVATNALLERKGERVALLVTRGFRDLLHIGTQARGDLFDLAVPMPEVLYEEVLEVDERVVLHRGEAGTGTPVKGRTGDLLEVQQPVDLGALRGKLEGLLSRGIRSLAVVLMHSYTWAQHEQQVGVLARELGFTHVSLSSEAMPMVRIVPRGHTACADAYLTPAIQRYVQGFCRGFQGQLKDVQVLFMRSDGGLAPMDTFSGSSAVLSGPAGGVVGYSATTYQQEGGQPVIGFDMGGTSTDVSRYAGEFEHVFEASTAGVTLQAPQLDINTVAAGGGSRLFFRSGLFVVGPESAGAHPGPACYRKGGPVTVTDANLVLGRLLPASFPCIFGPGENQPLSPEASRKALEAVATEVNSFLTNGPCPASPLSLEEVAMGFVRVANEAMCRPIRALTQARGHDPSAHVLACFGGAGGQHACAIARALGMDTVHIHRHSGLLSALGLALADVVHEAQEPCSLLYAPETFVQLDQRLSRLEEQCVDALQAQGFPRSQISTESFLHLRYQGTDCALMVSAHQHPATARSPRAGDFGAAFVERYMREFGFVIPERPVVVDDVRVRGTGRSGLRLEDAPKAQTGPPRVDKMTQCYFEGGYQETPVYLLAELGYGHKLHGPCLIIDSNSTILVEPGCQAEVTKTGDICISVGAEVPGTVGPQLDPIQLSIFSHRFMSIAEQMGRILQRTAISTNIKERLDFSCALFGPDGGLVSNAPHIPVHLGAMQETVQFQIQHLGADLHPGDVLLSNHPSAGGSHLPDLTVITPVFWPGQTRPVFYVASRGHHADIGGITPGSMPPHSTMLQQEGAVFLSFKLVQGGVFQEEAVTEALRAPGKVPNCSGTRNLHDNLSDLRAQVAANQKGIQLVGELIGQYGLDVVQAYMGHIQANAELAVRDMLRAFGTSRQARGLPLEVSSEDHMDDGSPIRLRVQISLSQGSAVFDFSGTGPEVFGNLNAPRAVTLSALIYCLRCLVGRDIPLNQGCLAPVRVVIPRGSILDPSPEAAVVGGNVLTSQRVVDVILGAFGACAASQGCMNNVTLGNAHMGYYETVAGGAGAGPSWHGRSGVHSHMTNTRITDPEILESRYPVILRRFELRRGSGGRGRFRGGDGVTRELLFREEALLSVLTERRAFRPYGLHGGEPGARGLNLLIRKNGRTVNLGGKTSVTVYPGDVFCLHTPGGGGYGDPEDPAPPPGSPPQALAFPEHGSVYEYRRAQEAV
uniprot
proteins
disease_involvement
DISEASE: 5-oxoprolinase deficiency (OPLAHD) [MIM:260005]: A disorder characterized by calcium oxalate/carbonate urolithiasis, and excessive urinary 5-oxo-L-proline. Affected individuals have recurrent episodes of vomiting, diarrhea, and abdominal pain. {ECO:0000269|PubMed:21651516, ECO:0000269|PubMed:23430506}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.5.2.9
uniprot
proteins
function
FUNCTION: Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. {ECO:0000250|UniProtKB:Q75WB5}.
uniprot
proteins
mass_dalton
137457
uniprot
proteins
protein_family
Oxoprolinase family
uniprot
proteins
pubmed
14993790
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21651516
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23430506
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
1288
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q75WB5}.
uniprot
proteins