SLC17A3
entrez
10786
canonical
uniprot
O00476
canonical
ensembl
ENSG00000124564
resolver
ensp
ENSP00000355307
resolver
ensp
ENSP00000380250
resolver
genesymbol
SLC17A3
resolver
genesymbol_syn
NPT4
resolver
hgnc
HGNC:10931
resolver
uniprot
B7WNJ5
resolver
uniprot
B7Z511
resolver
uniprot
Q8WWC7
resolver
uniprot
Q9H533
resolver
uniprot_entry
NPT4_HUMAN
resolver
uniprot_sec
B7WNJ5
resolver
uniprot_sec
B7Z511
resolver
uniprot_sec
Q8WWC7
resolver
uniprot_sec
Q9H533
resolver
amino_acid_sequence
MATKTELSPTARESKNAQDMQVDETLIPRKVPSLCSARYGIALVLHFCNFTTIAQNVIMNITMVAMVNSTSPQSQLNDSSEVLPVDSFGGLSKAPKSLPAKSSILGGQFAIWEKWGPPQERSRLCSIALSGMLLGCFTAILIGGFISETLGWPFVFYIFGGVGCVCCLLWFVVIYDDPVSYPWISTSEKEYIISSLKQQVGSSKQPLPIKAMLRSLPIWSICLGCFSHQWLVSTMVVYIPTYISSVYHVNIRDNGLLSALPFIVAWVIGMVGGYLADFLLTKKFRLITVRKIATILGSLPSSALIVSLPYLNSGYITATALLTLSCGLSTLCQSGIYINVLDIAPRYSSFLMGASRGFSSIAPVIVPTVSGFLLSQDPEFGWRNVFFLLFAVNLLGLLFYLIFGEADVQEWAKERKLTRL
uniprot
proteins
function
FUNCTION: Mediates the renal excretion of uremic toxin 3-indoxyl sulfate. {ECO:0000250|UniProtKB:Q5SZ93}.; FUNCTION: [Isoform 2]: Transports organic anions in a voltage-driven, multispecific, manner, on the apical side of renal proximal tubule (PubMed:20810651). In particular, participates in the secretion of urate from the cell into the lumen (PubMed:20810651). Urate is the end product of purine metabolism (PubMed:20810651). May have roles in the metabolism and secretion of estrone sulfate, estradiol-17-beta-glucuronide, ochratoxin A, as wells as drugs such as bumetanide (PubMed:20810651). {ECO:0000269|PubMed:20810651, ECO:0000303|PubMed:20810651}.
uniprot
proteins
mass_dalton
46106
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Sodium/anion cotransporter family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15505377
uniprot
proteins
pubmed
20810651
uniprot
proteins
pubmed
9149941
uniprot
proteins
sequence_length
420
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15505377}; Multi-pass membrane protein {ECO:0000269|PubMed:15505377}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:20810651}; Multi-pass membrane protein {ECO:0000269|PubMed:20810651}.
uniprot
proteins
transmembrane_region
TRANSMEM 126..146; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 154..174; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 218..238; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 256..276; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 292..314; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 319..341; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 357..377; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 385..405; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins