Papola
entrez
18789
canonical
uniprot
Q61183
canonical
ensembl
ENSMUSG00000021111
resolver
ensp
ENSMUSP00000105527
resolver
ensp
ENSMUSP00000126275
resolver
ensp
ENSMUSP00000132353
resolver
ensp
ENSMUSP00000258002
resolver
ensp
ENSMUSP00000258009
resolver
ensp
ENSMUSP00000258013
resolver
ensp
ENSMUSP00000345695
resolver
enst
ENSMUST00000170002
resolver
genesymbol
Papola
resolver
genesymbol_syn
Pap
resolver
genesymbol_syn
Plap
resolver
uniprot
E9PZR3
resolver
uniprot
Q3V141
resolver
uniprot
Q61208
resolver
uniprot
Q61209
resolver
uniprot
Q8K4X2
resolver
uniprot_entry
E9PZR3_MOUSE
resolver
uniprot_entry
PAPOA_MOUSE
resolver
uniprot_entry
Q3V141_MOUSE
resolver
uniprot_sec
Q61208
resolver
uniprot_sec
Q61209
resolver
uniprot_sec
Q8K4X2
resolver
amino_acid_sequence
MPFPVTTQGSQQTQPPQRHYGITSPISLAAPKETDCLLTQKLIETLKPFGVFEEEEELQRRILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVAPRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPEDLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNILGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVWDPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSKLFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQSFPAPKESPDREEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFELDMKIAAMHVKRKQLHQLLPSHVLQKRKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTSAMKTSPLNSSGSSQGRNSPAPAVTAASVTSIQASEVSVPQANSSESPGGPSSESIPQTATQPAISPPPKPTVSRVVSSTRLVNPSPRPSGNTATKVPNPIVGVKRTSSPNKEESPKKTKTEEDETSEDANCLALSGHDKTETKEQVDLETSAVQSETVPASASLLASQKTSSTDLSDIPALPANPIPVIKNSIKLRLNR
uniprot
proteins
ec_number
2.7.7.19
uniprot
proteins
function
FUNCTION: Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus. {ECO:0000250|UniProtKB:P51003, ECO:0000269|PubMed:18084034, ECO:0000269|PubMed:18281463}.
uniprot
proteins
mass_dalton
82309
uniprot
proteins
mutagenesis
MUTAGEN 444..445; /note="KK->RR: Some loss of sumoylation. No change in nuclear localization."; /evidence="ECO:0000269|PubMed:18281463"; MUTAGEN 537; /note="S->A: Eliminates MAPK-mediated phosphorylation."; /evidence="ECO:0000269|PubMed:18084034"; MUTAGEN 656..657; /note="KK->RR: Some loss of sumoylation; Largely localized to the cytoplasm."; /evidence="ECO:0000269|PubMed:18281463
uniprot
proteins
post_translational_modification
PTM: Polysumoylated. Varying sumoylation depending on tissue- and cell-type. Highly sumoylated in bladder and NIH 3T3 cells. Sumoylation is required for nuclear localization and enhances PAP stability. Desumoylated by SENP1. Inhibits polymerase activity. {ECO:0000269|PubMed:18281463}.; PTM: Hyperphosphorylation on multiple CDK2 consensus and non-consensus sites in the C-terminal Ser/Thr-rich region represses PAP activity in late M-phase. Phosphorylation/dephosphorylation may regulate the interaction between PAP and CPSF. {ECO:0000250|UniProtKB:P25500}.; PTM: Acetylated in the C-terminus. Acetylation decreases interaction with NUDT21 and KPNB1, and inhibits nuclear localization through inhibiting binding to the importin alpha/beta complex (By similarity). {ECO:0000250|UniProtKB:P25500}.
uniprot
proteins
protein_family
Poly(A) polymerase family
uniprot
proteins
pubmed
11716503
uniprot
proteins
pubmed
12471261
uniprot
proteins
pubmed
18084034
uniprot
proteins
pubmed
18281463
uniprot
proteins
pubmed
19224921
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8628305
uniprot
proteins
sequence_length
739
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18281463}. Cytoplasm {ECO:0000250|UniProtKB:P51003}.
uniprot
proteins