Iqsec2
entrez
245666
canonical
uniprot
Q5DU25
canonical
ensembl
ENSMUSG00000041115
resolver
ensp
ENSMUSP00000093995
resolver
ensp
ENSMUSP00000108223
resolver
ensp
ENSMUSP00000108224
resolver
ensp
ENSMUSP00000127249
resolver
ensp
ENSMUSP00000159486
resolver
enst
ENSMUST00000096275
resolver
enst
ENSMUST00000112604
resolver
enst
ENSMUST00000112605
resolver
enst
ENSMUST00000146835
resolver
enst
ENSMUST00000168786
resolver
genesymbol
Iqsec2
resolver
genesymbol_syn
IQArfGEF
resolver
genesymbol_syn
Kiaa0522
resolver
uniprot
A0A8V5KYN1
resolver
uniprot
A4GZ26
resolver
uniprot
D3Z5I6
resolver
uniprot
D3Z6V7
resolver
uniprot
E9QAD8
resolver
uniprot
E9QK46
resolver
uniprot
F6S5M4
resolver
uniprot_entry
A0A8V5KYN1_MOUSE
resolver
uniprot_entry
A4GZ26_MOUSE
resolver
uniprot_entry
D3Z5I6_MOUSE
resolver
uniprot_entry
D3Z6V7_MOUSE
resolver
uniprot_entry
E9QAD8_MOUSE
resolver
uniprot_entry
F6S5M4_MOUSE
resolver
uniprot_entry
IQEC2_MOUSE
resolver
uniprot_sec
E9QK46
resolver
activity_regulation
ACTIVITY REGULATION: Under resting conditions, it is inactive due to interaction with calmodulin (CALM1) that blocks the ARFs binding site. Allosterically activated by Ca(2+) ions that bind to CALM1, trigger its dissociation from IQSEC2, and induce IQSEC2 active state. {ECO:0000250|UniProtKB:Q5JU85}.
uniprot
proteins
amino_acid_sequence
MEAGSGPPGGPGSESPNRAVEYLLELNNIIESQQQLLETQRRRIEELEGQLDQLTQENRDLREESQLHRGELHRDPLGARDSPGRESQYQNLRETQFHHRELRESQFHQASRDVGYPNRDGAYQNREAIYRDKEREASYQLQDTTGYTARERDVAQCHLHHENPALGRERGGREAGPAHPGREKEAGYSAAVGVGQRPPRERGQLSRGASRSSSPGAGGGHSTSTSTSPATTLQRNVEGDAPGSDLSTAVDSPGSQPPYRLSQLPPTSSHMGGPPAGVGLPWAQRARLQPASVALRKQEEEEIKRSKALSDSYELSTDLQDKKVEMLERKYGGSFLSRRAARTIQTAFRQYRMNKNFERLRSSASESRMSRRIILSNMRMQFSFEEYEKAQNPAYFEGKPASLDEGAMAGARSHRLERGLPYGGSCGGGIDGGGSSVTTSGEFSNDITELEDSFSKQVKSLAESIDEALNCHPSGPMSEEPGSAQLEKRESKEQQEDSSATSFSDLPLYLDDPVPPPSPERLPSTEPPPQGRPEFWAPAPLPPVPPPMPPGTREDGSREEGTRRGPGCLECRDFRLRAAHLPLLTIEPPSDSSVDLSDRSDRGSVHRQLVYEADGCSPHGTLKHKGPPGRAPIPHRHYPAPEGPAPAPPGPLPPAPNSGTGPSGVAGGRRLGKCEAAGENSDGGDNESLESSSNSNETINCSSGSSSRDSLREPPATGLCKQTYQRETRHSWDSPAFNNDVVQRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQKQFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALVRQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGIYQRIQGRELRTNDDHVSQVQAVERMIVGKKPVLSLPHRRLVCCCQLYEVPDPNRPQRLGLHQREVFLFNDLLVVTKIFQKKKILVTYSFRQSFPLVEMHMQLFQNSYYQFGIKLLSAVPGGERKVLIIFNAPSLQDRLRFTSDLRESIAEVQEMEKYRVESELEKQKGMMRPNASQPGGAKDSVNGTLARSSLEDTYGAGDGLKRGALSSSLRDLSDAGKRGRRNSVGSLDSTIEGSVISSPRPHQRMPPPPPPPPPEEYKSQRPVSNSSSFLGSLFGSKRGKGPFQMPPPPTGQASASSSSASSTHHHHHHHHHGHSHGGLGVLPDGQSKLQALHAQYCQGPGPAPPPYLPPQQPPLPPPPQQPPPLPQLGSIPPPPASAPPVGPHRHFHAHGPVPGPQHYTLGRPGRAPRRGAGGHPQFAPHGRHPLHQPTSPLPLYSPAPQHPPAHKQGPKHFIFSHHPQMMPAAGAAGGPGSRPPGGSYSHPHHPQSPLSPHSPIPPHPSYPPLPPPSPHTPHSPLPPTSPHGPLHASGPPGTANPPSANPKAKPSRISTVV
uniprot
proteins
function
FUNCTION: Is a guanine nucleotide exchange factor (GEF) for small GTPases of the ARF family, promoting activation of specific ARFs through exchange of GDP for GTP. In vitro, it has GEF activity towards ARF6 and less potently towards ARF1 (PubMed:18164504). Is involved in the regulation of synaptic transmission and plasticity, controlling trafficking and removal of AMPA receptors GRIA2/GLUA2 and GRIA3/GLUA3 at synapses (By similarity). Additionally, it may regulate the assembly of the post-synaptic density in a Ca(2+)-dependent manner, operating independently of its GEF activity (By similarity). {ECO:0000250|UniProtKB:Q5JU85, ECO:0000269|PubMed:18164504}.
uniprot
proteins
mass_dalton
161787
uniprot
proteins
protein_family
BRAG family
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
18164504
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
1478
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, dendritic spine {ECO:0000269|PubMed:18164504}. Postsynaptic density {ECO:0000269|PubMed:18164504}.
uniprot
proteins