Ddit4
entrez
74747
canonical
uniprot
Q9D3F7
canonical
ensembl
ENSMUSG00000020108
resolver
ensp
ENSMUSP00000020308
resolver
enst
ENSMUST00000020308
resolver
genesymbol
Ddit4
resolver
genesymbol_syn
Dig2
resolver
genesymbol_syn
Redd1
resolver
genesymbol_syn
Rtp801
resolver
uniprot
B7ZNP9
resolver
uniprot_entry
B7ZNP9_MOUSE
resolver
uniprot_entry
DDIT4_MOUSE
resolver
amino_acid_sequence
MPSLWDRFSSSSSSSSSSRTPAADRPPRSAWGSAAREEGLDRCASLESSDCESLDSSNSGFGPEEDSSYLDGVSLPDFELLSDPEDEHLCANLMQLLQESLSQARLGSRRPARLLMPSQLVSQVGKELLRLAYSEPCGLRGALLDVCVEQGKSCHSVAQLALDPSLVPTFQLTLVLRLDSRLWPKIQGLLSSANSSLVPGYSQSLTLSTGFRVIKKKLYSSEQLLIEEC
uniprot
proteins
function
FUNCTION: Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes. Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death. Required for mTORC1-mediated defense against viral protein synthesis and virus replication. {ECO:0000269|PubMed:15545625, ECO:0000269|PubMed:15988001, ECO:0000269|PubMed:20176937, ECO:0000269|PubMed:21383064, ECO:0000269|PubMed:21896779, ECO:0000269|PubMed:21909097}.
uniprot
proteins
mass_dalton
24871
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by GSK3B; this promotes proteasomal degradation. {ECO:0000250}.; PTM: Polyubiquitinated by a DCX (DDB1-CUL4A-RBX1) E3 ubiquitin-protein ligase complex with BTRC as substrate-recognition component, leading to its proteasomal degradation. {ECO:0000250}.
uniprot
proteins
protein_family
DDIT4 family
uniprot
proteins
pubmed
11884613
uniprot
proteins
pubmed
12453409
uniprot
proteins
pubmed
12736248
uniprot
proteins
pubmed
15452091
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15545625
uniprot
proteins
pubmed
15988001
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17005863
uniprot
proteins
pubmed
20176937
uniprot
proteins
pubmed
21383064
uniprot
proteins
pubmed
21896779
uniprot
proteins
pubmed
21909097
uniprot
proteins
sequence_length
229
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:20176937}. Cytoplasm, cytosol {ECO:0000269|PubMed:20176937}.
uniprot
proteins