Adra1a
entrez
29412
canonical
uniprot
P43140
canonical
ensembl
ENSRNOG00000009522
resolver
ensp
ENSRNOP00000012736
resolver
ensp
ENSRNOP00000103621
resolver
enst
ENSRNOT00000012736
resolver
enst
ENSRNOT00000163065
resolver
genesymbol
Adra1a
resolver
genesymbol_syn
Adra1c
resolver
uniprot
A0A8L2Q6V0
resolver
uniprot
A0ABK0LG70
resolver
uniprot_entry
A0A8L2Q6V0_RAT
resolver
uniprot_entry
A0ABK0LG70_RAT
resolver
uniprot_entry
ADA1A_RAT
resolver
amino_acid_sequence
MVLLSENASEGSNCTHPPAPVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWVLSLVISIGPLFGWRQPAPEDETICQINEEPGYVLFSALGSFYVPLAIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNVPAEGGGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPDFKPSETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTLHPPSQALEGQHRDMVRIPVGSGETFYKISKTDGVCEWKFFSSMPQGSARITVPKDQSACTTARVRSKSFLQVCCCVGSSAPRPEENHQVPTIKIHTISLGENGEEV
uniprot
proteins
function
FUNCTION: Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C. ADRA1A binds the catecholamine ligands norepinephrine and epinephrine (By similarity). Can also couple to G(14) protein (By similarity). Nuclear ADRA1A forms heterooligomers with ADRA1B to regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. At the plasma membrane, ADRA1A interacts with CAVIN4/MURC to regulates ERK activation in cardiomyocytes, contributing to the regulation of cardiac hypertrophy (By similarity). Additionally, functions as a vasopressor in resistance arteries and plays a role in maintaining normal arterial blood pressure (By similarity). {ECO:0000250|UniProtKB:P18130, ECO:0000250|UniProtKB:P35348, ECO:0000250|UniProtKB:P97718}.
uniprot
proteins
mass_dalton
51598
uniprot
proteins
post_translational_modification
PTM: C-terminal Ser or Thr residues may be phosphorylated. {ECO:0000250}.
uniprot
proteins
protein_family
ADRA1A sub-subfamily
uniprot
proteins
protein_family
Adrenergic receptor subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
7923624
uniprot
proteins
pubmed
7935320
uniprot
proteins
pubmed
8185565
uniprot
proteins
sequence_length
466
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250|UniProtKB:P35348}; Multi-pass membrane protein. Cell membrane {ECO:0000250|UniProtKB:P35348}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:P35348}. Membrane, caveola {ECO:0000250|UniProtKB:P35348}. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes. Colocalizes with CAVIN4 and CAV3 at the plasma membrane and partly within the cytoplasm in cardiomyocytes. {ECO:0000250|UniProtKB:P35348}.
uniprot
proteins
transmembrane_region
TRANSMEM 28..51; /note="Helical; Name=1"; /evidence="ECO:0000250"; TRANSMEM 65..88; /note="Helical; Name=2"; /evidence="ECO:0000250"; TRANSMEM 100..122; /note="Helical; Name=3"; /evidence="ECO:0000250"; TRANSMEM 144..167; /note="Helical; Name=4"; /evidence="ECO:0000250"; TRANSMEM 182..205; /note="Helical; Name=5"; /evidence="ECO:0000250"; TRANSMEM 274..297; /note="Helical; Name=6"; /evidence="ECO:0000250"; TRANSMEM 306..329; /note="Helical; Name=7"; /evidence="ECO:0000250
uniprot
proteins