EDEM2
entrez
55741
canonical
uniprot
Q9BV94
canonical
ensembl
ENSG00000088298
resolver
ensp
ENSP00000363615
resolver
ensp
ENSP00000363616
resolver
genesymbol
EDEM2
resolver
genesymbol_syn
C20orf31
resolver
genesymbol_syn
C20orf49
resolver
hgnc
HGNC:15877
resolver
uniprot
B4DTG9
resolver
uniprot
Q6GU33
resolver
uniprot
Q6IA89
resolver
uniprot
Q6UWZ4
resolver
uniprot
Q9H4U0
resolver
uniprot
Q9H886
resolver
uniprot
Q9NTL9
resolver
uniprot
Q9NVE6
resolver
uniprot_entry
EDEM2_HUMAN
resolver
uniprot_sec
B4DTG9
resolver
uniprot_sec
Q6GU33
resolver
uniprot_sec
Q6IA89
resolver
uniprot_sec
Q6UWZ4
resolver
uniprot_sec
Q9H4U0
resolver
uniprot_sec
Q9H886
resolver
uniprot_sec
Q9NTL9
resolver
uniprot_sec
Q9NVE6
resolver
amino_acid_sequence
MPFRLLIPLGLLCALLPQHHGAPGPDGSAPDPAHYRERVKAMFYHAYDSYLENAFPFDELRPLTCDGHDTWGSFSLTLIDALDTLLILGNVSEFQRVVEVLQDSVDFDIDVNASVFETNIRVVGGLLSAHLLSKKAGVEVEAGWPCSGPLLRMAEEAARKLLPAFQTPTGMPYGTVNLLHGVNPGETPVTCTAGIGTFIVEFATLSSLTGDPVFEDVARVALMRLWESRSDIGLVGNHIDVLTGKWVAQDAGIGAGVDSYFEYLVKGAILLQDKKLMAMFLEYNKAIRNYTRFDDWYLWVQMYKGTVSMPVFQSLEAYWPGLQSLIGDIDNAMRTFLNYYTVWKQFGGLPEFYNIPQGYTVEKREGYPLRPELIESAMYLYRATGDPTLLELGRDAVESIEKISKVECGFATIKDLRDHKLDNRMESFFLAETVKYLYLLFDPTNFIHNNGSTFDAVITPYGECILGAGGYIFNTEAHPIDPAALHCCQRLKEEQWEVEDLMREFYSLKRSRSKFQKNTVSSGPWEPPARPGTLFSPENHDQARERKPAKQKVPLLSCPSQPFTSKLALLGQVFLDSS
uniprot
proteins
function
FUNCTION: Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner (PubMed:15537790, PubMed:25092655). May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655). Seems to recognize and bind to exposed hydrophobic regions in target proteins (By similarity). {ECO:0000250|UniProtKB:Q8BJT9, ECO:0000269|PubMed:15537790, ECO:0000269|PubMed:25092655}.
uniprot
proteins
mass_dalton
64753
uniprot
proteins
mutagenesis
MUTAGEN 117; /note="E->Q: Loss of ERAD activity."; /evidence="ECO:0000269|PubMed:25092655
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:15537790}.
uniprot
proteins
protein_family
Glycosyl hydrolase 47 family
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15537790
uniprot
proteins
pubmed
25092655
uniprot
proteins
sequence_length
578
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:15537790}.
uniprot
proteins