TIMD4
entrez
91937
canonical
uniprot
Q96H15
canonical
ensembl
ENSG00000145850
resolver
ensp
ENSP00000274532
resolver
ensp
ENSP00000385973
resolver
genesymbol
TIMD4
resolver
genesymbol_syn
TIM4
resolver
hgnc
HGNC:25132
resolver
uniprot
B5MCL9
resolver
uniprot_entry
TIMD4_HUMAN
resolver
uniprot_sec
B5MCL9
resolver
amino_acid_sequence
MSKEPLILWLMIEFWWLYLTPVTSETVVTEVLGHRVTLPCLYSSWSHNSNSMCWGKDQCPYSGCKEALIRTDGMRVTSRKSAKYRLQGTIPRGDVSLTILNPSESDSGVYCCRIEVPGWFNDVKINVRLNLQRASTTTHRTATTTTRRTTTTSPTTTRQMTTTPAALPTTVVTTPDLTTGTPLQMTTIAVFTTANTCLSLTPSTLPEEATGLLTPEPSKEGPILTAESETVLPSDSWSSVESTSADTVLLTSKESKVWDLPSTSHVSMWKTSDSVSSPQPGASDTAVPEQNKTTKTGQMDGIPMSMKNEMPISQLLMIIAPSLGFVLFALFVAFLLRGKLMETYCSQKHTRLDYIGDSKNVLNDVQHGREDEDGLFTL
uniprot
proteins
function
FUNCTION: Phosphatidylserine receptor that plays different role in immune response including phagocytosis of apoptotic cells and T-cell regulation (PubMed:18082433, PubMed:32640697). Involved in efferocytosis, the process by which apoptotic cells are removed by phagocytic cells by promoting the engulfment of apoptotic cells or exogenous particles (PubMed:18082433, PubMed:32703939, PubMed:34067457). Mechanistically, acts by securing apoptotic cells to phagocytes through direct binding to phosphatidylserine present on apoptotic cells, while other engulfment receptors such as MERTK efficiently recognize apoptotic cells and mediate their ingestion (PubMed:32640697). Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cell cycle arrest, while increasing proliferation of activated T-cells by activating AKT1 and ERK1/2 phosphorylations and subsequent signaling pathways (By similarity). Also promotes autophagy process by suppressing NLRP3 inflammasome activity via activation of LKB1/PRKAA1 pathway in a phosphatidylserine-dependent mechanism (By similarity). {ECO:0000250|UniProtKB:Q6U7R4, ECO:0000269|PubMed:18082433, ECO:0000269|PubMed:32640697, ECO:0000269|PubMed:32703939, ECO:0000269|PubMed:34067457}.; FUNCTION: (Microbial infection) Plays a positive role in exosome-mediated trafficking of HIV-1 virus and its entry into immune cells. {ECO:0000269|PubMed:28740388}.
uniprot
proteins
mass_dalton
41578
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
protein_family
TIM family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18082433
uniprot
proteins
pubmed
28740388
uniprot
proteins
pubmed
32640697
uniprot
proteins
pubmed
32703939
uniprot
proteins
pubmed
34067457
uniprot
proteins
sequence_length
378
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:32640697, ECO:0000269|PubMed:32703939, ECO:0000269|PubMed:34067457}; Single-pass type I membrane protein {ECO:0000305}. Secreted, extracellular exosome {ECO:0000269|PubMed:28740388}.
uniprot
proteins
transmembrane_region
TRANSMEM 315..335; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins