Hcrt
entrez
15171
canonical
uniprot
O55241
canonical
ensembl
ENSMUSG00000045471
resolver
ensp
ENSMUSP00000057578
resolver
enst
ENSMUST00000055083
resolver
genesymbol
Hcrt
resolver
genesymbol_syn
Ox
resolver
genesymbol_syn
Ppox
resolver
uniprot
Q547R2
resolver
uniprot_entry
OREX_MOUSE
resolver
uniprot_entry
Q547R2_MOUSE
resolver
amino_acid_sequence
MNFPSTKVPWAAVTLLLLLLLPPALLSLGVDAQPLPDCCRQKTCSCRLYELLHGAGNHAAGILTLGKRRPGPPGLQGRLQRLLQANGNHAAGILTMGRRAGAELEPHPCSGRGCPTVTTTALAPRGGSGV
uniprot
proteins
function
FUNCTION: Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. {ECO:0000250|UniProtKB:O55232}.; FUNCTION: [Orexin-A]: Binds to orexin receptors HCRTR1/OX1R and HCRTR2/OX2R with a high affinity (By similarity). Stimulates food intake (By similarity). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (By similarity). {ECO:0000250|UniProtKB:O55232}.; FUNCTION: [Orexin-B]: Binds to orexin receptor HCRTR2/OX2R only (By similarity). Stimulates food intake (By similarity). Modulates pituitary luteinizing hormone secretion in an ovarian steroid-dependent manner (By similarity). {ECO:0000250|UniProtKB:O55232}.
uniprot
proteins
mass_dalton
13503
uniprot
proteins
post_translational_modification
PTM: Specific enzymatic cleavages at paired basic residues yield the different active peptides.
uniprot
proteins
protein_family
Orexin family
uniprot
proteins
pubmed
11283317
uniprot
proteins
pubmed
11340621
uniprot
proteins
pubmed
9419374
uniprot
proteins
pubmed
9491897
uniprot
proteins
sequence_length
130
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Rough endoplasmic reticulum {ECO:0000250|UniProtKB:O55232}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:O55232}. Synapse {ECO:0000250|UniProtKB:O55232}. Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses. {ECO:0000250|UniProtKB:O55232}.
uniprot
proteins