RNLS
entrez
55328
canonical
uniprot
Q5VYX0
canonical
ensembl
ENSG00000184719
resolver
ensp
ENSP00000332530
resolver
ensp
ENSP00000361015
resolver
genesymbol
RNLS
resolver
genesymbol_syn
C10orf59
resolver
hgnc
HGNC:25641
resolver
uniprot
B4DJW3
resolver
uniprot
Q9BS33
resolver
uniprot
Q9NUP8
resolver
uniprot_entry
B4DJW3_HUMAN
resolver
uniprot_entry
RNLS_HUMAN
resolver
uniprot_sec
Q9BS33
resolver
uniprot_sec
Q9NUP8
resolver
amino_acid_sequence
MAQVLIVGAGMTGSLCAALLRRQTSGPLYLAVWDKAEDSGGRMTTACSPHNPQCTADLGAQYITCTPHYAKKHQRFYDELLAYGVLRPLSSPIEGMVMKEGDCNFVAPQGISSIIKHYLKESGAEVYFRHRVTQINLRDDKWEVSKQTGSPEQFDLIVLTMPVPEILQLQGDITTLISECQRQQLEAVSYSSRYALGLFYEAGTKIDVPWAGQYITSNPCIRFVSIDNKKRNIESSEIGPSLVIHTTVPFGVTYLEHSIEDVQELVFQQLENILPGLPQPIATKCQKWRHSQVTNAAANCPGQMTLHHKPFLACGGDGFTQSNFDGCITSALCVLEALKNYI
uniprot
proteins
ec_number
1.6.3.5
uniprot
proteins
function
FUNCTION: Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. {ECO:0000269|PubMed:15841207, ECO:0000269|PubMed:17385068, ECO:0000269|PubMed:25531177}.
uniprot
proteins
mass_dalton
37847
uniprot
proteins
protein_family
Renalase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15841207
uniprot
proteins
pubmed
17385068
uniprot
proteins
pubmed
21699903
uniprot
proteins
pubmed
23964689
uniprot
proteins
pubmed
25531177
uniprot
proteins
sequence_length
342
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:15841207}.
uniprot
proteins