Dll4
entrez
311332
canonical
uniprot
D3ZHH1
canonical
ensembl
ENSRNOG00000014011
resolver
ensp
ENSRNOP00000091766
resolver
enst
ENSRNOT00000117478
resolver
genesymbol
Dll4
resolver
uniprot_entry
DLL4_RAT
resolver
amino_acid_sequence
MTPGSRSACRWALLLLAVLWPQQRAAGSGIFQLRLQEFANERGMLANGRPCEPGCRTFFRICLKHYQATFSEGPCTFGNVSTPVLGTNSFVIRDKNSGSGRNPLQLPFNFTWPGTFSLNIQAWHTPGDDLRPETSPGNSLISQIIIQGSLAVGKNWKSDEQNNTLTRLRYSYRVVCSDNYYGDSCSRLCKKRDDHFGHYECQPDGSLSCLPGWTGKYCDQPICLSGCHEQNGYCSKPDECNCRPGWQGPLCNECIPHNGCRHGTCTIPWQCACDEGWGGLFCDQDLNYCTHHSPCKNGSTCSNSGPRGYTCTCLPGYTGEHCELELSKCASNPCRNGGSCKDHENSYHCLCPPGYYGQHCEHSTLTCADSPCFNGGSCRERNQGASYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRTCRCRPGFTGTHCELHISDCARSPCAHGGTCHDLENGPVCTCPAGFSGRRCEVRITNDACASGPCFNGATCYTGLSPNNFVCNCPYGFVGSRCEFPVGLPPSFPWVAVSLGVGLVVLLVLLVMVAVAVRQLRLRRPDDDSREAMNNLSDFQKDNLIPAAQLKNTNQKKELEVDCGLDKSNCGKLQNHTLDYNLAPGFLGRGSTPGKYPHSDKSLGEKVPLRLHSEKPACRISAICSPRDSMYQSVCLISEERNECVIATEV
uniprot
proteins
function
FUNCTION: Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4 (PubMed:25700513). Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate (By similarity). {ECO:0000250|UniProtKB:Q9JI71, ECO:0000250|UniProtKB:Q9NR61, ECO:0000269|PubMed:25700513}.
uniprot
proteins
mass_dalton
74961
uniprot
proteins
mutagenesis
MUTAGEN 65; /note="H->A: Strongly decreased binding to Notch1."; /evidence="ECO:0000269|PubMed:25700513"; MUTAGEN 66; /note="Y->A: Decreased binding to Notch1."; /evidence="ECO:0000269|PubMed:25700513"; MUTAGEN 196; /note="F->A: Strongly decreased binding to Notch1."; /evidence="ECO:0000269|PubMed:25700513"; MUTAGEN 217; /note="Y->A: No binding to Notch1."; /evidence="ECO:0000269|PubMed:25700513
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
25700513
uniprot
proteins
sequence_length
686
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:25700513}; Single-pass type I membrane protein {ECO:0000255|RuleBase:RU280815}.
uniprot
proteins
transmembrane_region
TRANSMEM 531..551; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins