SDS
entrez
10993
canonical
uniprot
P20132
canonical
ensembl
ENSG00000135094
resolver
ensp
ENSP00000257549
resolver
ensp
ENSP00000550905
resolver
ensp
ENSP00000550906
resolver
ensp
ENSP00000550907
resolver
ensp
ENSP00000550908
resolver
ensp
ENSP00000550910
resolver
ensp
ENSP00000550911
resolver
ensp
ENSP00000550912
resolver
ensp
ENSP00000550913
resolver
ensp
ENSP00000550914
resolver
ensp
ENSP00000550916
resolver
ensp
ENSP00000550917
resolver
ensp
ENSP00000550922
resolver
ensp
ENSP00000550923
resolver
ensp
ENSP00000550924
resolver
enst
ENST00000257549
resolver
enst
ENST00000880846
resolver
enst
ENST00000880847
resolver
enst
ENST00000880848
resolver
enst
ENST00000880849
resolver
enst
ENST00000880851
resolver
enst
ENST00000880852
resolver
enst
ENST00000880853
resolver
enst
ENST00000880854
resolver
enst
ENST00000880855
resolver
enst
ENST00000880857
resolver
enst
ENST00000880858
resolver
enst
ENST00000880863
resolver
enst
ENST00000880864
resolver
enst
ENST00000880865
resolver
genesymbol
SDS
resolver
genesymbol_syn
SDH
resolver
hgnc
HGNC:10691
resolver
uniprot
A8K9P5
resolver
uniprot
Q8WW81
resolver
uniprot_entry
Q8WW81_HUMAN
resolver
uniprot_entry
SDHL_HUMAN
resolver
uniprot_sec
A8K9P5
resolver
amino_acid_sequence
MMSGEPLHVKTPIRDSMALSKMAGTSVYLKMDSAQPSGSFKIRGIGHFCKRWAKQGCAHFVCSSAGNAGMAAAYAARQLGVPATIVVPSTTPALTIERLKNEGATVKVVGELLDEAFELAKALAKNNPGWVYIPPFDDPLIWEGHASIVKELKETLWEKPGAIALSVGGGGLLCGVVQGLQEVGWGDVPVIAMETFGAHSFHAATTAGKLVSLPKITSVAKALGVKTVGAQALKLFQEHPIFSEVISDQEAVAAIEKFVDDEKILVEPACGAALAAVYSHVIQKLQLEGNLRTPLPSLVVIVCGGSNISLAQLRALKEQLGMTNRLPK
uniprot
proteins
ec_number
4.3.1.17
uniprot
proteins
ec_number
4.3.1.19
uniprot
proteins
function
FUNCTION: Catalyzes the pyridoxal-phosphate-dependent dehydrative deamination of L-threonine and L-serine to ammonia and alpha-ketobutyrate and pyruvate, respectively. {ECO:0000269|PubMed:15618015, ECO:0000269|PubMed:15689518, ECO:0000269|PubMed:16580895, ECO:0000269|PubMed:18342636}.
uniprot
proteins
mass_dalton
34625
uniprot
proteins
mutagenesis
MUTAGEN 128; /note="Missing: Reduced Km and Vmax for both L-serine and L-threonine. 10-fold increase in dissociation constant for pyridoxal-phosphate."; /evidence="ECO:0000269|PubMed:16580895"; MUTAGEN 303; /note="C->A: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:18342636
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
uniprot
proteins
protein_family
Serine/threonine dehydratase family
uniprot
proteins
pubmed
14646100
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15618015
uniprot
proteins
pubmed
15689518
uniprot
proteins
pubmed
16580895
uniprot
proteins
pubmed
18342636
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2674117
uniprot
proteins
sequence_length
328
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P09367}.
uniprot
proteins