NIT2
entrez
56954
canonical
uniprot
Q9NQR4
canonical
ensembl
ENSG00000114021
resolver
ensp
ENSP00000377696
resolver
enst
ENST00000394140
resolver
genesymbol
HEL-S-8a
resolver
genesymbol
NIT2
resolver
hgnc
HGNC:29878
resolver
uniprot
B2R9A3
resolver
uniprot
D3DN47
resolver
uniprot
Q8WUF0
resolver
uniprot
V9HW91
resolver
uniprot_entry
NIT2_HUMAN
resolver
uniprot_entry
V9HW91_HUMAN
resolver
uniprot_sec
B2R9A3
resolver
uniprot_sec
D3DN47
resolver
uniprot_sec
Q8WUF0
resolver
amino_acid_sequence
MTSFRLALIQLQISSIKSDNVTRACSFIREAATQGAKIVSLPECFNSPYGAKYFPEYAEKIPGESTQKLSEVAKECSIYLIGGSIPEEDAGKLYNTCAVFGPDGTLLAKYRKIHLFDIDVPGKITFQESKTLSPGDSFSTFDTPYCRVGLGICYDMRFAELAQIYAQRGCQLLVYPGAFNLTTGPAHWELLQRSRAVDNQVYVATASPARDDKASYVAWGHSTVVNPWGEVLAKAGTEEAIVYSDIDLKKLAEIRQQIPVFRQKRSDLYAVEMKKP
uniprot
proteins
ec_number
3.5.1.3
uniprot
proteins
function
FUNCTION: Has omega-amidase activity (PubMed:19595734, PubMed:22674578). The role of omega-amidase is to remove potentially toxic intermediates by converting 2-oxoglutaramate and 2-oxosuccinamate to biologically useful 2-oxoglutarate and oxaloacetate, respectively (PubMed:19595734). {ECO:0000269|PubMed:19595734, ECO:0000269|PubMed:22674578}.
uniprot
proteins
mass_dalton
30608
uniprot
proteins
mutagenesis
MUTAGEN 43; /note="E->A: Loss of activity using succinamate as substrate."; /evidence="ECO:0000269|PubMed:22674578"; MUTAGEN 112; /note="K->A: Loss of activity using succinamate as substrate."; /evidence="ECO:0000269|PubMed:22674578"; MUTAGEN 116..128; /note="Missing: Less than 3% of wild-type activity using succinamate as substrate."; /evidence="ECO:0000269|PubMed:22674578"; MUTAGEN 153; /note="C->A: Loss of activity using succinamate as substrate."; /evidence="ECO:0000269|PubMed:22674578
uniprot
proteins
protein_family
Carbon-nitrogen hydrolase superfamily
uniprot
proteins
protein_family
NIT1/NIT2 family
uniprot
proteins
pubmed
10959838
uniprot
proteins
pubmed
14528910
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
17488281
uniprot
proteins
pubmed
19595734
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22674578
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
276
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17488281}.
uniprot
proteins