Ciart
entrez
229599
canonical
uniprot
Q3TQ03
canonical
ensembl
ENSMUSG00000038550
resolver
ensp
ENSMUSP00000049308
resolver
ensp
ENSMUSP00000124943
resolver
ensp
ENSMUSP00000327574
resolver
enst
ENSMUST00000036418
resolver
enst
ENSMUST00000159739
resolver
genesymbol
Ciart
resolver
genesymbol_syn
Gm129
resolver
uniprot
A2RTE4
resolver
uniprot
Q3U1B8
resolver
uniprot_entry
A2RTE4_MOUSE
resolver
uniprot_entry
CIART_MOUSE
resolver
uniprot_sec
Q3U1B8
resolver
amino_acid_sequence
MDSPSSVSSYSSSSLSPSFSTSSVNSDFSFPSDNEREGKGTHELRPDTVGQRGGSRPSPGPIRCRHRPRVSSNQHTAPHLEQQGSEVKRSRDGEQETSLNTQGCTTEGDLLFAQKCKELQGFIRPLTDLLNGLKMGRFDRGLSSFQQSVAMDRIQRIVGVLQKPQMGERYLGTLLQVEGMLKTWFPHIAAQKSSSGGSRHQISKHFPSHHGDPGAASPAPLLEKMGQTQLGHLVLKPKQPWHLTGWPAMNLTWIHSTPICNPPLSSQGSASGHSPIGTGASIGVILVLQKGGQPFTHSAPGTPVPPTPLSPVVPGDLKKLPGEEPRCHSLPVTLPSDWSCILCPPVLPTTDREMTKGHPEPQMTSHPPVAPDPQP
uniprot
proteins
function
FUNCTION: Transcriptional repressor which forms a negative regulatory component of the circadian clock and acts independently of the circadian transcriptional repressors: CRY1, CRY2 and BHLHE41. In a histone deacetylase-dependent manner represses the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Abrogates the interaction of BMAL1 with the transcriptional coactivator CREBBP and can repress the histone acetyl-transferase activity of the CLOCK-BMAL1 heterodimer, reducing histone acetylation of its target genes. Rhythmically binds the E-box elements (5'-CACGTG-3') on circadian gene promoters and its occupancy shows circadian oscillation antiphasic to BMAL1. Interacts with the glucocorticoid receptor (NR3C1) and contributes to the repressive function in the glucocorticoid response. {ECO:0000269|PubMed:24385426, ECO:0000269|PubMed:24736997, ECO:0000269|PubMed:24737000}.
uniprot
proteins
mass_dalton
40408
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
24385426
uniprot
proteins
pubmed
24736997
uniprot
proteins
pubmed
24737000
uniprot
proteins
sequence_length
375
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Nucleus, PML body. Note=Co-localizes with the CLOCK-BMAL1 heterodimer in the PML body.
uniprot
proteins