P2rx6
entrez
25041
canonical
uniprot
P51579
canonical
ensembl
ENSRNOG00000001873
resolver
ensembl
ENSRNOG00055003773
resolver
ensembl
ENSRNOG00060011274
resolver
ensembl
ENSRNOG00065008032
resolver
ensp
ENSRNOP00000002558
resolver
ensp
ENSRNOP00000096439
resolver
ensp
ENSRNOP00000111441
resolver
ensp
ENSRNOP00055004483
resolver
ensp
ENSRNOP00060014884
resolver
ensp
ENSRNOP00065009335
resolver
enst
ENSRNOT00000100698
resolver
enst
ENSRNOT00000150988
resolver
enst
ENSRNOT00055005942
resolver
enst
ENSRNOT00060019063
resolver
enst
ENSRNOT00065012681
resolver
genesymbol
P2rx6
resolver
genesymbol_syn
P2rxl1
resolver
uniprot
A0A8I6ATC1
resolver
uniprot
A0ABK0M4H7
resolver
uniprot
R9PXR5
resolver
uniprot_entry
A0A8I6ATC1_RAT
resolver
uniprot_entry
A0ABK0M4H7_RAT
resolver
uniprot_entry
P2RX6_RAT
resolver
uniprot_sec
R9PXR5
resolver
amino_acid_sequence
MQLQPAGTGSMASAVAAALVSWGFLDYKTEKYVMTRNCWVGISQRLLQLGVVVYVIGWALLAKKGYQEWDMDPQISVITKLKGVSVTQVKELEKRLWDVADFVRPSQGENVFFLVTNFLVTPAQVQGRCPEHPSVPLANCWADEDCPEGEMGTYSHGIKTGQCVAFNGTHRTCEIWSWCPVESSAVPRKPLLAQAKNFTLFIKNTVTFNKFNFSRTNALDTWDNTYFKYCLYDSLSSPYCPVFRIGDLVAMTGGDFEDLALLGGAVGINIHWDCNLDTKGSDCSPQYSFQLQERGYNFRTANYWWAASGVESRSLLKLYGIRFDILVTGQAGKFALIPTAITVGTGAAWLGMVTFLCDLLLLYVDREAGFYWRTKYEEARAPKATTNSA
uniprot
proteins
function
FUNCTION: Acts as a modulatory subunit rather than a functional channel. Unlike other P2XRs members, P2RX6 does not seem to form functional homotrimers (PubMed:10037762). P2RX6 requires the presence of P2RX4 or P2RX2 to become functional at the cell surface (PubMed:10864944). P2RX6 can be translocated to the nucleus and functions as a nuclear regulator of post-transcriptional modifications in neurons (By similarity). {ECO:0000250|UniProtKB:O54803, ECO:0000269|PubMed:10037762, ECO:0000269|PubMed:10864944}.
uniprot
proteins
mass_dalton
43422
uniprot
proteins
mutagenesis
MUTAGEN 13; /note="S->K: Promotes the formation of homotrimers; when associated with K-21."; /evidence="ECO:0000269|PubMed:16452399"; MUTAGEN 21; /note="S->K: Promotes the formation of homotrimers; when associated with K-13."; /evidence="ECO:0000269|PubMed:16452399
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. N-linked glycosylation can affect trafficking to the membrane and function. {ECO:0000269|PubMed:15044628}.
uniprot
proteins
protein_family
P2X receptor family
uniprot
proteins
pubmed
10037762
uniprot
proteins
pubmed
10864944
uniprot
proteins
pubmed
12077178
uniprot
proteins
pubmed
15044628
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15657042
uniprot
proteins
pubmed
16452399
uniprot
proteins
pubmed
17449665
uniprot
proteins
pubmed
24815693
uniprot
proteins
pubmed
8670303
uniprot
proteins
pubmed
8786426
uniprot
proteins
sequence_length
389
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15044628, ECO:0000269|PubMed:16452399}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum {ECO:0000269|PubMed:12077178, ECO:0000269|PubMed:16452399}. Nucleus {ECO:0000250|UniProtKB:O54803}. Nucleus inner membrane {ECO:0000250|UniProtKB:O54803}; Multi-pass membrane protein {ECO:0000255}. Note=Monomers remain anchored to the endoplasmic reticulum (ER) membrane by the hydrophobic N-terminal end (PubMed:12077178, PubMed:15044628, PubMed:16452399). Heteromerization of P2RX6 subunits with either P2RX2 or P2RX4 subunits guides the P2RX6 subunit to the plasma membrane (PubMed:16452399). Retention of P2RX6 subunit in the ER allows it to reach the nucleus (PubMed:16452399). In neurons, mainly expressed in the cell body of the hippocampal neurons (By similarity). {ECO:0000250|UniProtKB:O54803, ECO:0000269|PubMed:12077178, ECO:0000269|PubMed:15044628, ECO:0000269|PubMed:16452399}.
uniprot
proteins
transmembrane_region
TRANSMEM 42..62; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 336..356; /note="Helical; Name=2"; /evidence="ECO:0000255
uniprot
proteins