Sesn3
entrez
75747
canonical
uniprot
Q9CYP7
canonical
ensembl
ENSMUSG00000032009
resolver
ensp
ENSMUSP00000146362
resolver
enst
ENSMUST00000208222
resolver
genesymbol
Sesn3
resolver
uniprot
A2RSF4
resolver
uniprot
Q3U2A0
resolver
uniprot_entry
A2RSF4_MOUSE
resolver
uniprot_entry
SESN3_MOUSE
resolver
uniprot_sec
Q3U2A0
resolver
amino_acid_sequence
MNRGGSSASASANYLLCTNCRKVLRKDKRIRVSQPLTRGPSAFIPEKEVVQANTADERTNFLVEEYSTSGRLDNITQVMSLHTQYLESFLRSQFYMLRMDGPLPLPDRHYIAIMAAARHQCSYLINMHVDEFLKTGGIAEWLNGLEYVPQRLRNLNEINKLLAHRPWLITKEHIQKLVKTGENNWSLPELVHAVVLLAHYHALASFVFGSGINPERDPGIANGFRLISVSSFCVCDLANDNSIENTSLAGSNFGIVDSLGELEALMERMKRLQEDREDDETTREEMTTRFEKEKKESLFVVPGETLHAFPHSDFEDDVIVTADVSRYIEDPSFGYEDFARRGEEHLPTFRAQDYTWENHGFSLVNRLYSDIGHLLDEKFRMVYNLTYNTMATHEDVDTTTLRRALFNYVHCMFGIRYDDYDYGEVNQLLERSLKVYIKTVTCYPERTTKRMYDSYWRQFTHSEKVHVNLLLMEARMQAELLYALRAITRHLT
uniprot
proteins
ec_number
1.11.1.-
uniprot
proteins
function
FUNCTION: May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway (PubMed:25259925). May also regulate the insulin-receptor signaling pathway through activation of TORC2 (PubMed:25377878). This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). {ECO:0000250|UniProtKB:P58004, ECO:0000269|PubMed:25259925, ECO:0000269|PubMed:25377878}.
uniprot
proteins
mass_dalton
57021
uniprot
proteins
protein_family
Sestrin family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
22958918
uniprot
proteins
pubmed
25259925
uniprot
proteins
pubmed
25377878
uniprot
proteins
sequence_length
492
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25377878}.
uniprot
proteins