CD8B
entrez
926
canonical
uniprot
P10966
canonical
ensembl
ENSG00000172116
resolver
ensp
ENSP00000331172
resolver
ensp
ENSP00000340592
resolver
ensp
ENSP00000375070
resolver
ensp
ENSP00000377356
resolver
ensp
ENSP00000377358
resolver
ensp
ENSP00000660634
resolver
genesymbol
CD8B
resolver
genesymbol_syn
CD8B1
resolver
hgnc
HGNC:1707
resolver
uniprot
P14860
resolver
uniprot
P14861
resolver
uniprot
Q15980
resolver
uniprot
Q496E0
resolver
uniprot
Q496E1
resolver
uniprot
Q496E2
resolver
uniprot
Q9UDB4
resolver
uniprot
Q9UDB5
resolver
uniprot
Q9UDB6
resolver
uniprot
Q9UDB7
resolver
uniprot
Q9UDB8
resolver
uniprot
Q9UDB9
resolver
uniprot
Q9UDC0
resolver
uniprot
Q9UQ55
resolver
uniprot_entry
CD8B_HUMAN
resolver
uniprot_sec
P14860
resolver
uniprot_sec
P14861
resolver
uniprot_sec
Q15980
resolver
uniprot_sec
Q496E0
resolver
uniprot_sec
Q496E1
resolver
uniprot_sec
Q496E2
resolver
uniprot_sec
Q9UDB4
resolver
uniprot_sec
Q9UDB5
resolver
uniprot_sec
Q9UDB6
resolver
uniprot_sec
Q9UDB7
resolver
uniprot_sec
Q9UDB8
resolver
uniprot_sec
Q9UDB9
resolver
uniprot_sec
Q9UDC0
resolver
uniprot_sec
Q9UQ55
resolver
amino_acid_sequence
MRPRLWLLLAAQLTVLHGNSVLQQTPAYIKVQTNKMVMLSCEAKISLSNMRIYWLRQRQAPSSDSHHEFLALWDSAKGTIHGEEVEQEKIAVFRDASRFILNLTSVKPEDSGIYFCMIVGSPELTFGKGTQLSVVDFLPTTAQPTKKSTLKKRVCRLPRPETQKGPLCSPITLGLLVAGVLVLLVSLGVAIHLCCRRRRARLRFMKQFYK
uniprot
proteins
function
FUNCTION: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, plays a critical role in thymic selection of CD8+ T-cells. {ECO:0000250|UniProtKB:P10300, ECO:0000269|PubMed:10925291, ECO:0000269|PubMed:11714755, ECO:0000269|PubMed:17145893}.
uniprot
proteins
mass_dalton
23722
uniprot
proteins
post_translational_modification
PTM: Phosphorylated as a consequence of T-cell activation. {ECO:0000305}.; PTM: Palmitoylated at the cytoplasmic tail and thereby targets the heterodimer CD8A/CD8B to lipid rafts unlike CD8A homodimers. {ECO:0000269|PubMed:10925291}.
uniprot
proteins
pubmed
10925291
uniprot
proteins
pubmed
11714755
uniprot
proteins
pubmed
1541829
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17145893
uniprot
proteins
pubmed
3145195
uniprot
proteins
pubmed
3145196
uniprot
proteins
pubmed
3264320
uniprot
proteins
pubmed
8436166
uniprot
proteins
sequence_length
210
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:11714755, ECO:0000269|PubMed:3145196}; Single-pass type I membrane protein {ECO:0000305}. Note=Requires the partner CD8A for efficient cell surface expression (PubMed:3145196). The heterodimer CD8A/CD8B localizes to lipid rafts due to CD8B cytoplasmic tail palmitoylation. {ECO:0000269|PubMed:10925291, ECO:0000269|PubMed:11714755, ECO:0000269|PubMed:3145196}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 5]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 6]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 7]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 8]: Secreted {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 171..191; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins