ASF1B
entrez
55723
canonical
uniprot
Q9NVP2
canonical
ensembl
ENSG00000105011
resolver
ensembl
ENSG00000288210
resolver
ensp
ENSP00000263382
resolver
ensp
ENSP00000499863
resolver
enst
ENST00000263382
resolver
enst
ENST00000672225
resolver
genesymbol
ASF1B
resolver
hgnc
HGNC:20996
resolver
uniprot
Q53G51
resolver
uniprot
Q9NVZ0
resolver
uniprot_entry
ASF1B_HUMAN
resolver
uniprot_sec
Q53G51
resolver
uniprot_sec
Q9NVZ0
resolver
amino_acid_sequence
MAKVSVLNVAVLENPSPFHSPFRFEISFECSEALADDLEWKIIYVGSAESEEFDQILDSVLVGPVPAGRHMFVFQADAPNPSLIPETDAVGVTVVLITCTYHGQEFIRVGYYVNNEYLNPELRENPPMKPDFSQLQRNILASNPRVTRFHINWDNNMDRLEAIETQDPSLGCGLPLNCTPIKGLGLPGCIPGLLPENSMDCI
uniprot
proteins
function
FUNCTION: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly (PubMed:11897662, PubMed:14718166, PubMed:15664198, PubMed:16151251, PubMed:21454524, PubMed:26527279). Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly (PubMed:11897662, PubMed:14718166, PubMed:15664198, PubMed:16151251). Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' (H3K9me1) and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol (PubMed:20953179, PubMed:21454524, PubMed:26527279). Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA (PubMed:11897662, PubMed:14718166, PubMed:15664198, PubMed:16151251). Required for gonad development (PubMed:12842904). {ECO:0000269|PubMed:11897662, ECO:0000269|PubMed:12842904, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15664198, ECO:0000269|PubMed:16151251, ECO:0000269|PubMed:20953179, ECO:0000269|PubMed:21454524, ECO:0000269|PubMed:26527279}.
uniprot
proteins
mass_dalton
22434
uniprot
proteins
mutagenesis
MUTAGEN 36; /note="D->A: Abolishes CDAN1 interaction."; /evidence="ECO:0000269|PubMed:22407294"; MUTAGEN 37; /note="D->A: Abolishes CDAN1 interaction."; /evidence="ECO:0000269|PubMed:22407294"; MUTAGEN 169; /note="S->A: No apparent effect on ASF1B phosphorylation by TLK2. Reduced phosphorylation of ASF1B by TLK2 when associated with A-198."; /evidence="ECO:0000269|PubMed:35136069"; MUTAGEN 198; /note="S->A: Reduced phosphorylation of ASF1B by TLK2 when associated with A-169."; /evidence="ECO:0000269|PubMed:35136069
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by TLK1 and TLK2. {ECO:0000269|PubMed:11470414, ECO:0000269|PubMed:20016786, ECO:0000269|PubMed:35136069}.
uniprot
proteins
protein_family
ASF1 family
uniprot
proteins
pubmed
11470414
uniprot
proteins
pubmed
11897662
uniprot
proteins
pubmed
12842904
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14718166
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15664198
uniprot
proteins
pubmed
16151251
uniprot
proteins
pubmed
16537536
uniprot
proteins
pubmed
16980972
uniprot
proteins
pubmed
20016786
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20953179
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21454524
uniprot
proteins
pubmed
22195965
uniprot
proteins
pubmed
22407294
uniprot
proteins
pubmed
24616510
uniprot
proteins
pubmed
26527279
uniprot
proteins
pubmed
35136069
uniprot
proteins
sequence_length
202
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12842904}. Cytoplasm, cytosol {ECO:0000269|PubMed:22407294}.
uniprot
proteins