Ccl17
entrez
20295
canonical
uniprot
Q9WUZ6
canonical
ensembl
ENSMUSG00000031780
resolver
ensp
ENSMUSP00000034232
resolver
enst
ENSMUST00000034232
resolver
genesymbol
Ccl17
resolver
genesymbol_syn
Tarc
resolver
uniprot
F6R5P4
resolver
uniprot
Q9R043
resolver
uniprot_entry
CCL17_MOUSE
resolver
uniprot_entry
F6R5P4_MOUSE
resolver
uniprot_sec
Q9R043
resolver
amino_acid_sequence
MRSLQMLLLAALLLGTFLQHARAARATNVGRECCLDYFKGAIPIRKLVSWYKTSVECSRDAIVFLTVQGKLICADPKDKHVKKAIRLVKNPRP
uniprot
proteins
function
FUNCTION: Chemokine, which displays chemotactic activity for T lymphocytes, preferentially Th2 cells, but not monocytes or granulocytes. Therefore plays an important role in a wide range of inflammatory and immunological processes (PubMed:10508243, PubMed:10508268). Acts by binding to CCR4 at T-cell surface (By similarity). Mediates GM-CSF/CSF2-driven pain and inflammation (PubMed:27525438). In the brain, required to maintain the typical, highly branched morphology of hippocampal microglia under homeostatic conditions. May be important for the appropriate adaptation of microglial morphology and synaptic plasticity to acute lipopolysaccharide (LPS)-induced neuroinflammation (PubMed:30277599). Plays a role in wound healing, mainly by inducing fibroblast migration into the wound (PubMed:21521373). {ECO:0000250|UniProtKB:Q92583, ECO:0000269|PubMed:10508243, ECO:0000269|PubMed:10508268, ECO:0000269|PubMed:21521373, ECO:0000269|PubMed:27525438, ECO:0000269|PubMed:30277599}.
uniprot
proteins
mass_dalton
10467
uniprot
proteins
protein_family
Intercrine beta (chemokine CC) family
uniprot
proteins
pubmed
10508243
uniprot
proteins
pubmed
10508268
uniprot
proteins
pubmed
11093154
uniprot
proteins
pubmed
12615900
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21521373
uniprot
proteins
pubmed
27525438
uniprot
proteins
pubmed
29871928
uniprot
proteins
pubmed
30277599
uniprot
proteins
sequence_length
93
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:29871928, ECO:0000269|PubMed:30277599}.
uniprot
proteins