ABCF1
entrez
23
canonical
uniprot
Q8NE71
canonical
ensembl
ENSG00000204574
resolver
ensembl
ENSG00000206490
resolver
ensembl
ENSG00000225989
resolver
ensembl
ENSG00000231129
resolver
ensembl
ENSG00000232169
resolver
ensembl
ENSG00000236149
resolver
ensembl
ENSG00000236342
resolver
ensp
ENSP00000313603
resolver
ensp
ENSP00000365728
resolver
genesymbol
ABCF1
resolver
genesymbol_syn
ABC50
resolver
hgnc
HGNC:70
resolver
uniprot
A2BF75
resolver
uniprot
O14897
resolver
uniprot
Q69YP6
resolver
uniprot_entry
ABCF1_HUMAN
resolver
uniprot_sec
A2BF75
resolver
uniprot_sec
O14897
resolver
uniprot_sec
Q69YP6
resolver
amino_acid_sequence
MPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVASLKAANAAENDFSVSQAEMSSRQAMLENASDIKLEKFSISAHGKELFVNADLYIVAGRRYGLVGPNGKGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLKLLEEERRLQGQLEQGDDTAAERLEKVYEELRATGAAAAEAKARRILAGLGFDPEMQNRPTQKFSGGWRMRVSLARALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSHDQGFLDDVCTDIIHLDAQRLHYYRGNYMTFKKMYQQKQKELLKQYEKQEKKLKELKAGGKSTKQAEKQTKEALTRKQQKCRRKNQDEESQEAPELLKRPKEYTVRFTFPDPPPLSPPVLGLHGVTFGYQGQKPLFKNLDFGIDMDSRICIVGPNGVGKSTLLLLLTGKLTPTHGEMRKNHRLKIGFFNQQYAEQLRMEETPTEYLQRGFNLPYQDARKCLGRFGLESHAHTIQICKLSGGQKARVVFAELACREPDVLILDEPTNNLDIESIDALGEAINEYKGAVIVVSHDARLITETNCQLWVVEEQSVSQIDGDFEDYKREVLEALGEVMVSRPRE
uniprot
proteins
function
FUNCTION: Isoform 2 is required for efficient Cap- and IRES-mediated mRNA translation initiation. Isoform 2 is not involved in the ribosome biogenesis. {ECO:0000269|PubMed:19570978}.
uniprot
proteins
mass_dalton
95926
uniprot
proteins
mutagenesis
MUTAGEN 109; /note="S->A: Reduces phosphorylation. Inhibits strongly phosphorylation by CK2; when associated with S-140. Does not inhibit interaction with EIF2; when associated with S-140. Does not inhibit association with ribosomes; when associated with S-140. Reduces EIF2 interaction with ribosomes; when associated with S-140. Does not inhibit protein synthesis; when associated with A-140."; /evidence="ECO:0000269|PubMed:17894550"; MUTAGEN 140; /note="S->A: Reduces phosphorylation. Inhibits strongly phosphorylation by CK2; when associated with S-109. Does not inhibits interaction with EIF2; when associated with S-109. Does not inhibit association with ribosomes; when associated with S-109. Reduces EIF2 interaction with ribosomes; when associated with S-109. Does not inhibit protein synthesis; when associated with A-109."; /evidence="ECO:0000269|PubMed:17894550"; MUTAGEN 342; /note="K->M: Does not inhibit ribosome binding. Reduces ATP-binding. Inhibits ATP-binding and reduces protein synthesis; when associated with M-664. Shows an enhanced association with polyribosomes; when associated with M-664. Does not inhibit IRES-mediated protein synthesis; when associated with M-664."; /evidence="ECO:0000269|PubMed:19570978"; MUTAGEN 367; /note="Q->E: Does not inhibit ribosome binding."; /evidence="ECO:0000269|PubMed:19570978"; MUTAGEN 454; /note="G->D: Does not inhibit ribosome binding."; /evidence="ECO:0000269|PubMed:19570978"; MUTAGEN 477; /note="E->Q: Does not inhibit ribosome binding. Reduces protein synthesis; when associated with Q-768."; /evidence="ECO:0000269|PubMed:19570978"; MUTAGEN 506; /note="H->L: Does not inhibit ribosome binding."; /evidence="ECO:0000269|PubMed:19570978"; MUTAGEN 664; /note="K->M: Does not inhibit ribosome binding. Reduces ATP-binding. Inhibits ATP-binding and reduces protein synthesis; when associated with M-342. Shows a reduced association with polyribosomes; when associated with M-664. Does not inhibit IRES-mediated protein synthesis; when associated with M-664."; /evidence="ECO:0000269|PubMed:19570978"; MUTAGEN 695; /note="Q->E: Does not inhibit ribosome binding."; /evidence="ECO:0000269|PubMed:19570978"; MUTAGEN 745; /note="G->D: Does not inhibit ribosome binding."; /evidence="ECO:0000269|PubMed:19570978"; MUTAGEN 768; /note="E->Q: Does not inhibit ribosome binding. Reduces protein synthesis; when associated with Q-477."; /evidence="ECO:0000269|PubMed:19570978"; MUTAGEN 797; /note="H->L: Does not inhibit ribosome binding."; /evidence="ECO:0000269|PubMed:19570978
uniprot
proteins
post_translational_modification
PTM: Isoform 2 is phosphorylated at phosphoserine and phosphothreonine. Isoform 2 phosphorylation on Ser-109 and Ser-140 by CK2 inhibits association of EIF2 with ribosomes. {ECO:0000269|PubMed:17894550}.
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCF family
uniprot
proteins
protein_family
EF3 subfamily
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
17894550
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19570978
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9790762
uniprot
proteins
sequence_length
845
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:19570978}. Nucleus, nucleoplasm {ECO:0000269|PubMed:19570978}. Nucleus envelope {ECO:0000269|PubMed:19570978}.
uniprot
proteins