EHD1
entrez
10938
canonical
uniprot
Q9H4M9
canonical
ensembl
ENSG00000110047
resolver
ensp
ENSP00000320516
resolver
ensp
ENSP00000352354
resolver
ensp
ENSP00000479153
resolver
ensp
ENSP00000579842
resolver
enst
ENST00000320631
resolver
enst
ENST00000359393
resolver
enst
ENST00000621096
resolver
enst
ENST00000909783
resolver
genesymbol
EHD1
resolver
genesymbol_syn
PAST
resolver
genesymbol_syn
PAST1
resolver
hgnc
HGNC:3242
resolver
uniprot
A0A024R571
resolver
uniprot
B2R5U3
resolver
uniprot
O14611
resolver
uniprot
Q2M3Q4
resolver
uniprot
Q9UNR3
resolver
uniprot_entry
A0A024R571_HUMAN
resolver
uniprot_entry
B2R5U3_HUMAN
resolver
uniprot_entry
EHD1_HUMAN
resolver
uniprot_sec
O14611
resolver
uniprot_sec
Q2M3Q4
resolver
uniprot_sec
Q9UNR3
resolver
amino_acid_sequence
MFSWVSKDARRKKEPELFQTVAEGLRQLYAQKLLPLEEHYRFHEFHSPALEDADFDNKPMVLLVGQYSTGKTTFIRHLIEQDFPGMRIGPEPTTDSFIAVMHGPTEGVVPGNALVVDPRRPFRKLNAFGNAFLNRFMCAQLPNPVLDSISIIDTPGILSGEKQRISRGYDFAAVLEWFAERVDRIILLFDAHKLDISDEFSEVIKALKNHEDKIRVVLNKADQIETQQLMRVYGALMWSLGKIINTPEVVRVYIGSFWSHPLLIPDNRKLFEAEEQDLFKDIQSLPRNAALRKLNDLIKRARLAKVHAYIISSLKKEMPNVFGKESKKKELVNNLGEIYQKIEREHQISPGDFPSLRKMQELLQTQDFSKFQALKPKLLDTVDDMLANDIARLMVMVRQEESLMPSQVVKGGAFDGTMNGPFGHGYGEGAGEGIDDVEWVVGKDKPTYDEIFYTLSPVNGKITGANAKKEMVKSKLPNTVLGKIWKLADVDKDGLLDDEEFALANHLIKVKLEGHELPADLPPHLVPPSKRRHE
uniprot
proteins
function
FUNCTION: ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. In vitro causes vesiculation of endocytic membranes (PubMed:24019528). Acts in early endocytic membrane fusion and membrane trafficking of recycling endosomes (PubMed:15020713, PubMed:17233914, PubMed:20801876). Recruited to endosomal membranes upon nerve growth factor stimulation, indirectly regulates neurite outgrowth (By similarity). Plays a role in myoblast fusion (By similarity). Involved in the unidirectional retrograde dendritic transport of endocytosed BACE1 and in efficient sorting of BACE1 to axons implicating a function in neuronal APP processing (By similarity). Plays a role in the formation of the ciliary vesicle (CV), an early step in cilium biogenesis (PubMed:31615969). Proposed to be required for the fusion of distal appendage vesicles (DAVs) to form the CV by recruiting SNARE complex component SNAP29. Is required for recruitment of transition zone proteins CEP290, RPGRIP1L, TMEM67 and B9D2, and of IFT20 following DAV reorganization before Rab8-dependent ciliary membrane extension. Required for the loss of CCP110 form the mother centriole essential for the maturation of the basal body during ciliogenesis (PubMed:25686250). {ECO:0000250|UniProtKB:Q641Z6, ECO:0000250|UniProtKB:Q9WVK4, ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:20801876, ECO:0000269|PubMed:24019528, ECO:0000269|PubMed:25686250, ECO:0000269|PubMed:31615969}.
uniprot
proteins
mass_dalton
60627
uniprot
proteins
mutagenesis
MUTAGEN 65; /note="G->R: Abolishes ATP-binding and localizes to cytoplasm."; /evidence="ECO:0000269|PubMed:16251358"; MUTAGEN 203; /note="V->P: Greatly reduces oligomerization and interaction with RAB11FIP2."; /evidence="ECO:0000269|PubMed:16251358"; MUTAGEN 468; /note="K->A: Loss of interaction with MICALL1."; /evidence="ECO:0000269|PubMed:20106972"; MUTAGEN 483; /note="K->E: Loss of accumulation at the ciliary pocket. Loss of function in ciliogenesis. Loss of association with tubulovesicular structures and altered MICALL1 localization. No effect on MICALL1 localization; when associated with A-485."; /evidence="ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:25686250"; MUTAGEN 485; /note="W->A: Loss of accumulation at the ciliary pocket. Loss of function in ciliogenesis. Abolishes interaction with RAB11FIP2. No effect on MICALL1 localization; when associated with E-483."; /evidence="ECO:0000269|PubMed:16251358, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:25686250
uniprot
proteins
protein_family
Dynamin/Fzo/YdjA family
uniprot
proteins
protein_family
EHD subfamily
uniprot
proteins
protein_family
TRAFAC class dynamin-like GTPase superfamily
uniprot
proteins
pubmed
10395801
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
15020713
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16251358
uniprot
proteins
pubmed
17233914
uniprot
proteins
pubmed
17899392
uniprot
proteins
pubmed
18331452
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19864458
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20106972
uniprot
proteins
pubmed
20801876
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22284051
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23596323
uniprot
proteins
pubmed
24019528
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25686250
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
31615969
uniprot
proteins
pubmed
9253601
uniprot
proteins
sequence_length
534
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:23596323}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Early endosome membrane {ECO:0000269|PubMed:15020713}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:Q9WVK4}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, cilium membrane {ECO:0000269|PubMed:25686250, ECO:0000269|PubMed:31615969}; Peripheral membrane protein {ECO:0000305|PubMed:31615969}; Cytoplasmic side {ECO:0000305}. Note=Preferentially associates with tubular recycling endosomes (PubMed:15020713, PubMed:17233914, PubMed:19864458, PubMed:23596323). Colocalizes with FER1L5 at plasma membrane in myoblasts and myotubes (By similarity). Localizes to the ciliary pocket from where the cilium protrudes (PubMed:25686250). Colocalizes with BACE1 in tubulovesicular cytoplasmic membranes. Colocalizes with BACE1 and APP amyloid beta proteins in hippocampal mossy fiber terminals (By similarity). {ECO:0000250|UniProtKB:Q9WVK4, ECO:0000269|PubMed:15020713, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:19864458, ECO:0000269|PubMed:23596323, ECO:0000269|PubMed:25686250}.
uniprot
proteins