Bmpr1a
entrez
81507
canonical
uniprot
Q78EA7
canonical
ensembl
ENSRNOG00000052469
resolver
ensembl
ENSRNOG00055009048
resolver
ensembl
ENSRNOG00060014195
resolver
ensembl
ENSRNOG00065014276
resolver
ensp
ENSRNOP00000074885
resolver
ensp
ENSRNOP00055012270
resolver
ensp
ENSRNOP00060019389
resolver
ensp
ENSRNOP00065018320
resolver
enst
ENSRNOT00000079554
resolver
enst
ENSRNOT00055015312
resolver
enst
ENSRNOT00060024297
resolver
enst
ENSRNOT00065023550
resolver
genesymbol
Bmpr1a
resolver
uniprot
Q64308
resolver
uniprot_entry
BMR1A_RAT
resolver
uniprot_sec
Q64308
resolver
amino_acid_sequence
MTQLYTYIRLLGACLFIISHVQGQNLDSMLHGTGMKSDVDQKKPENGVTLAPEDTLPFLKCYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLTSGCMKYEGSDFQCKDSPKAQLRRTIECCRTNLCNQYLQPTLPPVVIGPFFDGSVRWLAVLISMAVCIVAMIVFSSCFCYKHYCKSISSRGRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQVGKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTGSWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAHRDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDIPLNTRVGTRRYMAPEVLDESLSKNHFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLRPIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI
uniprot
proteins
ec_number
2.7.11.30
uniprot
proteins
function
FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6. May promote the expression of HAMP, potentially via its interaction with BMP2 (By similarity). {ECO:0000250|UniProtKB:P36895}.
uniprot
proteins
mass_dalton
59994
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:P36895}.; PTM: Ubiquitinated by the complex made of the adapter SMAD6 and the E3 ligase SMURF1, leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q13950}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
TGFB receptor subfamily
uniprot
proteins
protein_family
TKL Ser/Thr protein kinase family
uniprot
proteins
pubmed
7897267
uniprot
proteins
pubmed
7945360
uniprot
proteins
sequence_length
532
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P36898}; Single-pass type I membrane protein {ECO:0000255}. Cell surface {ECO:0000250|UniProtKB:P36895}.
uniprot
proteins
transmembrane_region
TRANSMEM 153..176; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins