TPM2
entrez
7169
canonical
uniprot
P07951
canonical
ensembl
ENSG00000198467
resolver
ensp
ENSP00000367541
resolver
ensp
ENSP00000367542
resolver
ensp
ENSP00000495440
resolver
ensp
ENSP00000496494
resolver
ensp
ENSP00000737792
resolver
enst
ENST00000329305
resolver
enst
ENST00000647435
resolver
genesymbol
HEL-S-273
resolver
genesymbol
TPM2
resolver
genesymbol
TPM2b
resolver
genesymbol_syn
TMSB
resolver
hgnc
HGNC:12011
resolver
uniprot
A0A2R8YEA8
resolver
uniprot
A6NM85
resolver
uniprot
A7XZE4
resolver
uniprot
P06468
resolver
uniprot
Q13894
resolver
uniprot
Q53FM4
resolver
uniprot
Q5TCU3
resolver
uniprot
Q5TCU4
resolver
uniprot
Q5TCU7
resolver
uniprot
Q9UH67
resolver
uniprot
V9HW25
resolver
uniprot_entry
A0A2R8YEA8_HUMAN
resolver
uniprot_entry
A7XZE4_HUMAN
resolver
uniprot_entry
Q5TCU3_HUMAN
resolver
uniprot_entry
TPM2_HUMAN
resolver
uniprot_entry
V9HW25_HUMAN
resolver
uniprot_sec
A6NM85
resolver
uniprot_sec
P06468
resolver
uniprot_sec
Q13894
resolver
uniprot_sec
Q53FM4
resolver
uniprot_sec
Q5TCU4
resolver
uniprot_sec
Q5TCU7
resolver
uniprot_sec
Q9UH67
resolver
amino_acid_sequence
MDAIKKKMQMLKLDKENAIDRAEQAEADKKQAEDRCKQLEEEQQALQKKLKGTEDEVEKYSESVKEAQEKLEQAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIENRAMKDEEKMELQEMQLKEAKHIAEDSDRKYEEVARKLVILEGELERSEERAEVAESKCGDLEEELKIVTNNLKSLEAQADKYSTKEDKYEEEIKLLEEKLKEAETRAEFAERSVAKLEKTIDDLEDEVYAQKMKYKAISEELDNALNDITSL
uniprot
proteins
disease_involvement
DISEASE: Congenital myopathy 23 (CMYO23) [MIM:609285]: An autosomal dominant muscular disorder characterized clinically by hypotonia and muscle weakness, and a static or slowly progressive clinical course. Disease onset ranges from birth to childhood. Histologic examination of muscle fibers shows various anomalies including fiber type disproportion, an irregular myofibrillar network, abnormal thread-like or rod-shaped structures, and cap-like structures which are well demarcated and peripherally located under the sarcolemma with abnormal accumulation of sarcomeric proteins. {ECO:0000269|PubMed:11738357, ECO:0000269|PubMed:17434307, ECO:0000269|PubMed:17846275, ECO:0000269|PubMed:19047562, ECO:0000269|PubMed:19345583, ECO:0000269|PubMed:24692096}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Arthrogryposis, distal, 1A (DA1A) [MIM:108120]: A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. Distal arthrogryposis type 1 is characterized largely by camptodactyly and clubfoot. Hypoplasia and/or absence of some interphalangeal creases is common. The shoulders and hips are less frequently affected. {ECO:0000269|PubMed:12592607, ECO:0000269|PubMed:24692096}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Arthrogryposis, distal, 2B4 (DA2B4) [MIM:108120]: A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. Distal arthrogryposis type 2 is characterized by contractures of the hands and feet, and a distinctive face characterized by prominent nasolabial folds, small mouth and downslanting palpebral fissures. {ECO:0000269|PubMed:17339586, ECO:0000269|PubMed:23678273, ECO:0000269|PubMed:30285720}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments. The non-muscle isoform may have a role in agonist-mediated receptor internalization. {ECO:0000250|UniProtKB:P58774, ECO:0000250|UniProtKB:P58775}.
uniprot
proteins
mass_dalton
32851
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser-61 by PIK3CG. Phosphorylation on Ser-61 is required for ADRB2 internalization (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Tropomyosin family
uniprot
proteins
pubmed
11738357
uniprot
proteins
pubmed
11840567
uniprot
proteins
pubmed
12592607
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17339586
uniprot
proteins
pubmed
17434307
uniprot
proteins
pubmed
17846275
uniprot
proteins
pubmed
19047562
uniprot
proteins
pubmed
19345583
uniprot
proteins
pubmed
2059197
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2303454
uniprot
proteins
pubmed
23678273
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24692096
uniprot
proteins
pubmed
30285720
uniprot
proteins
pubmed
3368322
uniprot
proteins
pubmed
3865200
uniprot
proteins
sequence_length
284
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P58775}. Note=Associates with F-actin stress fibers. {ECO:0000250|UniProtKB:P58775}.
uniprot
proteins