Cox8a
entrez
12868
canonical
uniprot
Q64445
canonical
ensembl
ENSMUSG00000035885
resolver
ensp
ENSMUSP00000040717
resolver
enst
ENSMUST00000039758
resolver
genesymbol
Cox8a
resolver
genesymbol_syn
Cox8
resolver
genesymbol_syn
Cox8l
resolver
uniprot
Q0VBB1
resolver
uniprot
Q545I2
resolver
uniprot_entry
COX8A_MOUSE
resolver
uniprot_sec
Q0VBB1
resolver
uniprot_sec
Q545I2
resolver
amino_acid_sequence
MSVLTPLLLRSLTGSARRLMVPRAQVHSKPAREQLGVLDITIGLTSCFVCCLLPAGWVLSHLESYKKRE
uniprot
proteins
function
FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P10175}.
uniprot
proteins
mass_dalton
7648
uniprot
proteins
pathway_participation
PATHWAY: Energy metabolism; oxidative phosphorylation. {ECO:0000250|UniProtKB:P10175}.
uniprot
proteins
post_translational_modification
PTM: In response to mitochondrial stress, the precursor protein is ubiquitinated by the SIFI complex in the cytoplasm before mitochondrial import, leading to its degradation. Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1. {ECO:0000250|UniProtKB:P10176}.
uniprot
proteins
protein_family
Cytochrome c oxidase VIII family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
9166597
uniprot
proteins
sequence_length
69
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P10176}; Single-pass membrane protein {ECO:0000250|UniProtKB:P10176}.
uniprot
proteins
transmembrane_region
TRANSMEM 37..60; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P10175
uniprot
proteins