PITPNM2
entrez
57605
canonical
uniprot
Q9BZ72
canonical
ensembl
ENSG00000090975
resolver
ensp
ENSP00000280562
resolver
ensp
ENSP00000322218
resolver
ensp
ENSP00000546927
resolver
ensp
ENSP00000546929
resolver
ensp
ENSP00000546930
resolver
ensp
ENSP00000601370
resolver
ensp
ENSP00000643172
resolver
ensp
ENSP00000795346
resolver
genesymbol
PITPNM2
resolver
genesymbol_syn
KIAA1457
resolver
genesymbol_syn
NIR3
resolver
hgnc
HGNC:21044
resolver
uniprot
A5D8U3
resolver
uniprot
Q9P271
resolver
uniprot_entry
A5D8U3_HUMAN
resolver
uniprot_entry
PITM2_HUMAN
resolver
uniprot_sec
Q9P271
resolver
amino_acid_sequence
MIIKEYRIPLPMTVEEYRIAQLYMIQKKSRNETYGEGSGVEILENRPYTDGPGGSGQYTHKVYHVGMHIPSWFRSILPKAALRVVEESWNAYPYTRTRFTCPFVEKFSIDIETFYKTDAGENPDVFNLSPVEKNQLTIDFIDIVKDPVPHNEYKTEEDPKLFQSTKTQRGPLSENWIEEYKKQVFPIMCAYKLCKVEFRYWGMQSKIERFIHDTGLRRVMVRAHRQAWCWQDEWYGLSMENIRELEKEAQLMLSRKMAQFNEDGEEATELVKHEAVSDQTSGEPPEPSSSNGEPLVGRGLKKQWSTSSKSSRSSKRGASPSRHSISEWRMQSIARDSDESSDDEFFDAHEDLSDTEEMFPKDITKWSSNDLMDKIESPEPEDTQDGLYRQGAPEFRVASSVEQLNIIEDEVSQPLAAPPSKIHVLLLVLHGGTILDTGAGDPSSKKGDANTIANVFDTVMRVHYPSALGRLAIRLVPCPPVCSDAFALVSNLSPYSHDEGCLSSSQDHIPLAALPLLATSSPQYQEAVATVIQRANLAYGDFIKSQEGMTFNGQVCLIGDCVGGILAFDALCYSNQPVSESQSSSRRGSVVSMQDNDLLSPGILMNAAHCCGGGGGGGGGGGSSGGGGSSGGSSLESSRHLSRSNVDIPRSNGTEDPKRQLPRKRSDSSTYELDTIQQHQAFLSSLHASVLRTEPCSRHSSSSTMLDGTGALGRFDFEITDLFLFGCPLGLVLALRKTVIPALDVFQLRPACQQVYNLFHPADPSASRLEPLLERRFHALPPFSVPRYQRYPLGDGCSTLLADVLQTHNAAFQEHGAPSSPGTAPASRGFRRASEISIASQVSGMAESYTASSIAQKAPDALSHTPSVRRLSLLALPAPSPTTPGPHPPARKASPGLERAPGLPELDIGEVAAKWWGQKRIDYALYCPDALTAFPTVALPHLFHASYWESTDVVSFLLRQVMRHDNSSILELDGKEVSVFTPSKPREKWQRKRTHVKLRNVTANHRINDALANEDGPQVLTGRFMYGPLDMVTLTGEKVDVHIMTQPPSGEWLYLDTLVTNNSGRVSYTIPESHRLGVGVYPIKMVVRGDHTFADSYITVLPKGTEFVVFSIDGSFAASVSIMGSDPKVRAGAVDVVRHWQDLGYLIIYVTGRPDMQKQRVVAWLAQHNFPHGVVSFCDGLVHDPLRHKANFLKLLISELHLRVHAAYGSTKDVAVYSAISLSPMQIYIVGRPTKKLQQQCQFITDGYAAHLAQLKYSHRARPARNTATRMALRKGSFGLPGQGDFLRSRNHLLRTISAQPSGPSHRHERTQSQADGEQRGQRSMSVAAGCWGRAMTGRLEPGAAAGPK
uniprot
proteins
function
FUNCTION: Membrane-associated phosphatidylinositol (PI) transfer protein that shuttles PI between intracellular membranes and thereby maintains plasma membrane phosphoinositide signaling competence (PubMed:10022914, PubMed:25887399). Upon production of phosphatidic acid (PA), mediates the transfer of phosphatidylinositol from the endoplasmic reticulum to the plasma membrane at endoplasmic reticulum-plasma membrane contact sites. This transfer sustains phospholipase C (PLC)-coupled receptor signaling and replenishing of plasma membrane phosphoinositides following receptor-induced hydrolysis (PubMed:25887399). Promotes PIP2 replenishment following TCR stimulation; plays a critical role in T cell development by supporting calcium signaling in response to weak TCR stimulation during TCRbeta selection and positive selection of thymocytes, as well as maintaining peripheral T cell survival (By similarity). {ECO:0000250|UniProtKB:Q6ZPQ6, ECO:0000269|PubMed:10022914, ECO:0000269|PubMed:25887399}.
uniprot
proteins
mass_dalton
148933
uniprot
proteins
protein_family
PI transfer class IIA subfamily
uniprot
proteins
protein_family
PtdIns transfer protein family
uniprot
proteins
pubmed
10022914
uniprot
proteins
pubmed
10819331
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25887399
uniprot
proteins
pubmed
36581712
uniprot
proteins
sequence_length
1349
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25887399}; Peripheral membrane protein {ECO:0000269|PubMed:25887399}; Cytoplasmic side {ECO:0000269|PubMed:25887399}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:25887399}; Peripheral membrane protein {ECO:0000269|PubMed:25887399}; Cytoplasmic side {ECO:0000269|PubMed:25887399}. Note=Upon PIP2 hydrolysis, translocates to endoplasmic reticulum-plasma membrane contact sites. {ECO:0000269|PubMed:25887399}.
uniprot
proteins