Carnmt1
entrez
293871
canonical
uniprot
Q5BJZ6
canonical
ensembl
ENSRNOG00000012872
resolver
ensp
ENSRNOP00000017405
resolver
genesymbol
Carnmt1
resolver
uniprot
A0A0G3F9V8
resolver
uniprot_entry
CARME_RAT
resolver
uniprot_sec
A0A0G3F9V8
resolver
amino_acid_sequence
MQRRRRAPPASQPAQDSGHSEEVEVQFSAGRLGSAAPAGPPVRGTAEDEERLEREHFWKVINAFRYYGTSMHERVNRTERQFRSLPDNQQKLLPQFPLHLDKIRKCVDHNQEILLTIVNDCIHMFENKEYGEDANGKIMPASTFDMDKLKSTLKQFVRDWSGTGKAERDACYKPIIKEIIKNFPKERWDPSKVNILVPGAGLGRLAWEIAMLGYACQGNEWSFFMLFSSNFVLNRCSEVDKYKLYPWIHQFSNNRRSADQIRPIFFPDVDPHSLPPGSNFSMTAGDFQEIYSECNTWDCIATCFFIDTAHNVIDYIDTIWRILKPGGIWINLGPLLYHFENLANELSIELSYEDIKNVVLQYGFQLEVEKESVLSTYTVNDLSMMKYYYECVLFVVRKPQ
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
ec_number
2.1.1.22
uniprot
proteins
function
FUNCTION: Protein-histidine N-methyltransferase that specifically catalyzes the N1-methylation (pros-methylation) of histidine residues in a wide range of proteins. It primarily monomethylates proteins containing RNA-binding C3H1 zinc finger motifs, such as U2AF1, ZC3H15, ZC3H18, PPP1R10, PRR3 and RNF113A, thereby modulating mRNA splicing and turnover (By similarity). Additionally, it methylates the dipeptide carnosine (beta-alanyl-L-histidine) at the N1 position to generate anserine, an abundant component of vertebrate skeletal muscle. Acts also on other L-histidine-containing di- and tripeptides, such as Gly-Gly-His, Gly-His, and homocarnosine (GABA-His) (PubMed:26001783). {ECO:0000250|UniProtKB:Q8N4J0, ECO:0000269|PubMed:26001783}.
uniprot
proteins
mass_dalton
46385
uniprot
proteins
protein_family
Carnosine N-methyltransferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
26001783
uniprot
proteins
sequence_length
400
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:26001783}. Nucleus {ECO:0000269|PubMed:26001783}.
uniprot
proteins