Lypd6
entrez
320343
canonical
uniprot
Q8BPP5
canonical
ensembl
ENSMUSG00000050447
resolver
ensp
ENSMUSP00000061578
resolver
ensp
ENSMUSP00000108332
resolver
ensp
ENSMUSP00000131002
resolver
ensp
ENSMUSP00000281952
resolver
enst
ENSMUST00000053208
resolver
enst
ENSMUST00000112712
resolver
enst
ENSMUST00000169232
resolver
genesymbol
Lypd6
resolver
uniprot_entry
LYPD6_MOUSE
resolver
amino_acid_sequence
MEPSPALAWLLLLSLVADCLKAAQSRDFTVKDIIYLHPSTTPYPGGFKCFTCEKAADNYECNRWAPDIYCPRDTRYCYTQHTMEVTGNSISVTKRCVPLEECLSTGCRDSEHEGYKICTSCCEGNICNLPLPRNETDATFATTSPINQTNGHPHCVSVIVSCLWVWLGLTL
uniprot
proteins
function
FUNCTION: Acts as a modulator of nicotinic acetylcholine receptors (nAChRs) function in the brain (PubMed:19403274). Inhibits nicotine-induced Ca(2+) influx through nAChRs (By similarity). In vitro, specifically inhibits alpha-3:beta-4 and alpha-7 nAChR currents in an allosteric manner (By similarity). Acts as a positive regulator of Wnt/beta-catenin signaling (By similarity). {ECO:0000250|UniProtKB:Q66IA6, ECO:0000250|UniProtKB:Q86Y78, ECO:0000269|PubMed:19403274}.
uniprot
proteins
mass_dalton
19065
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19403274
uniprot
proteins
pubmed
25680266
uniprot
proteins
sequence_length
171
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q86Y78}. Cytoplasm {ECO:0000250|UniProtKB:Q86Y78}. Cell membrane {ECO:0000255}; Lipid-anchor, GPI-anchor {ECO:0000255}. Synapse, synaptosome {ECO:0000250|UniProtKB:D3ZTT2}. Membrane raft {ECO:0000250|UniProtKB:Q66IA6}. Cell projection, dendrite {ECO:0000250|UniProtKB:D3ZTT2}. Perikaryon {ECO:0000250|UniProtKB:D3ZTT2}. Note=Colocalizes with alpha-3:beta-4- and alpha-7- nicotinic acetylcholine receptors (nAChRs) in the primary cortex and hippocampus. {ECO:0000250|UniProtKB:D3ZTT2}.
uniprot
proteins