TENT4B
entrez
64282
canonical
uniprot
Q8NDF8
canonical
ensembl
ENSG00000121274
resolver
ensp
ENSP00000396995
resolver
ensp
ENSP00000455837
resolver
enst
ENST00000561678
resolver
genesymbol
TENT4B
resolver
genesymbol_syn
GLD4
resolver
genesymbol_syn
PAPD5
resolver
genesymbol_syn
TRF4-2
resolver
genesymbol_syn
TUT3
resolver
hgnc
HGNC:30758
resolver
uniprot
A0A7N4YH79
resolver
uniprot
B4DV38
resolver
uniprot
Q9NW67
resolver
uniprot
Q9Y6C0
resolver
uniprot_entry
A0A7N4YH79_HUMAN
resolver
uniprot_entry
PAPD5_HUMAN
resolver
uniprot_sec
B4DV38
resolver
uniprot_sec
Q9NW67
resolver
uniprot_sec
Q9Y6C0
resolver
amino_acid_sequence
MYRSGERLLGSHALPAEQRDFLPLETTNNNNNHHQPGAWARRAGSSASSPPSASSSPHPSAAVPAADPADSASGSSNKRKRDNKASGGRAAGGGRADGGGVVYSGTPWKRRNYNQGVVGLHEEISDFYEYMSPRPEEEKMRMEVVNRIESVIKELWPSADVQIFGSFKTGLYLPTSDIDLVVFGKWENLPLWTLEEALRKHKVADEDSVKVLDKATVPIIKLTDSFTEVKVDISFNVQNGVRAADLIKDFTKKYPVLPYLVLVLKQFLLQRDLNEVFTGGIGSYSLFLMAVSFLQLHPREDACIPNTNYGVLLIEFFELYGRHFNYLKTGIRIKDGGSYVAKDEVQKNMLDGYRPSMLYIEDPLQPGNDVGRSSYGAMQVKQAFDYAYVVLSHAVSPIAKYYPNNETESILGRIIRVTDEVATYRDWISKQWGLKNRPEPSCNGPVSSSSATQSSSSDVDSDATPCKTPKQLLCRPSTGNRVGSQDVSLESSQAVGKMQSTQTTNTSNSTNKSQHGSARLFRSSSKGFQGTTQTSHGSLMTNKQHQGKSNNQYYHGKKRKHKRDAPLSDLCR
uniprot
proteins
ec_number
2.7.7.-
uniprot
proteins
ec_number
2.7.7.19
uniprot
proteins
function
FUNCTION: Terminal nucleotidyltransferase that catalyzes preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:21788334, PubMed:30026317). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Doesn't need a cofactor for polyadenylation activity (in vitro) (PubMed:21788334, PubMed:21855801). Required for cytoplasmic polyadenylation of mRNAs involved in carbohydrate metabolism, including the glucose transporter SLC2A1/GLUT1 (PubMed:28383716). Plays a role in replication-dependent histone mRNA degradation, probably through terminal uridylation of mature histone mRNAs. May play a role in sister chromatid cohesion (PubMed:18172165). Mediates 3' adenylation of the microRNA MIR21 followed by its 3'-to-5' trimming by the exoribonuclease PARN leading to degradation (PubMed:25049417). Mediates 3' adenylation of H/ACA box snoRNAs (small nucleolar RNAs) followed by its 3'-to-5' trimming by the exoribonuclease PARN which enhances snoRNA stability and maturation (PubMed:22442037). {ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:21788334, ECO:0000269|PubMed:21855801, ECO:0000269|PubMed:22442037, ECO:0000269|PubMed:25049417, ECO:0000269|PubMed:28383716, ECO:0000269|PubMed:30026317}.
uniprot
proteins
mass_dalton
63267
uniprot
proteins
protein_family
DNA polymerase type-B-like family
uniprot
proteins
pubmed
10066793
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18172165
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21788334
uniprot
proteins
pubmed
21855801
uniprot
proteins
pubmed
22442037
uniprot
proteins
pubmed
22817747
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23376078
uniprot
proteins
pubmed
25049417
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28383716
uniprot
proteins
pubmed
30026317
uniprot
proteins
sequence_length
572
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:21788334}. Nucleus, nucleolus {ECO:0000269|PubMed:21855801, ECO:0000269|PubMed:23376078}. Cytoplasm {ECO:0000269|PubMed:18172165, ECO:0000269|PubMed:28383716}. Note=Predominantly expressed in the cytoplasm (PubMed:18172165).
uniprot
proteins