Nphp3
entrez
74025
canonical
uniprot
Q7TNH6
canonical
ensembl
ENSMUSG00000032558
resolver
ensp
ENSMUSP00000035167
resolver
genesymbol
Nphp3
resolver
genesymbol_syn
Kiaa2000
resolver
uniprot
D6RHB4
resolver
uniprot
E9Q5X1
resolver
uniprot
E9QN29
resolver
uniprot
Q69Z39
resolver
uniprot
Q8C798
resolver
uniprot
Q8C7Z3
resolver
uniprot
Q9D6D1
resolver
uniprot_entry
NPHP3_MOUSE
resolver
uniprot_sec
D6RHB4
resolver
uniprot_sec
E9Q5X1
resolver
uniprot_sec
E9QN29
resolver
uniprot_sec
Q69Z39
resolver
uniprot_sec
Q8C798
resolver
uniprot_sec
Q8C7Z3
resolver
uniprot_sec
Q9D6D1
resolver
amino_acid_sequence
MGTASSLVSPTGGEVIEDTYGAGGGEACEIPVEVKPKARLLRSSFRRGAGAGPGSLPRAAGGGGLLGASFKSTGSSVPELEYAAAEFERLKKEYEIFRVSKNQELLSMGRREAKLDTENKRLRAELQALQKTYQKILREKEGALEAKYQAMERAVTFEHDRDRVKRQFKIFRETKENEIQDLLRAKRELESKLQRLQAQGIQVFDPGESDSDDNCTDVTAAGTQCEYWASRALGSEHSIGSMIQLPQPFRGPEFAHSSIDVEGPFANINRDDWDAAVAGLLQATPLFSHSLWSHPVRCYLIYTDETQPEMELFLKDHSPKLKRMCETMGYFFLAVYFPLDVENQYLTVRKWEIEKSSLVILFLHSTLPSFLLEDCEEAFLQNPEGKPGLIYHRLEDGKVTCDSVQQFLDQVSNLGKTTKAKIIEHSGDPAEGVCKIYVGVEKIIKQDILGLENTDVEEKDGGREDSTPEEDDFGDVLWDIHDEQEQMEAFQQTSSSAHELGFEKYYQRLDDLVVAPAPIPPLLVSGGPGSGKSLLLSKWIQLQQKHFPNTLILSHFVGRPMSTSSESSLIIKRLTLKLMQHFWAVSALTLDPAKLLEEFPHWLEKLSARHQGSIIIIIDSIDQVQQVEKHMKWLIDPLPVNVRVIVSVNVETCPTAWRLWPTLHLDPLSPKDAISIITAECYSMDVRLSREQEKMLEQHCRPATTRHALYVTLFSKMMACAGRGGNVAETLHQCLQCQDTVSLYKLVLHHVRESMPSDRDKEWMTQILCLINVSHNGVSESELMELYPEMSWLSLTSIVHSLHKMHLLTYSCGLLRFQHLQAWETVRLQYLEDPALVSSYREKLISYFASQLSQDRVTWRSADELPWLFQQQGSKQKLHSCLLNLLVAQNLYKRGHFAELLSYWQFVGKDKGAMATEYFESLKQYENSEGEENMLCLADLYETLGRFLKDLGLLSQAVVPLQRSLEIRETALDPDHPRVAQSLHQLAGVYVQWKKFGDAEQLYKQALEISENAYGADHPHAARELEALATLYHKQNKYEQAEHFRKKSVIIRQQATRRKGSLYGFALLRRRALQLEELTLGKDKPENARTLNELGVLYFLQNNLETAEQFLKRSLEMRERVLGPDHPDCAQSLNNLAALCNEKKQYEKAEELYERALDIRRRALAPDHPSLAYTVKHLAILYKKTGKVDKAVPLYELAVEIRQKSFGPKHPSVATALVNLAVLHSQMKKHSEALPLYERALKIYEDSLGRMHPRVGETLKNLAVLSYEEGNFEKAAELYKRAMEIKEAETSLLGGKAPSRQSSSGDTFLFKTTHSPNVFLPQGQS
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Nphp3 may be the cause of polycystic kidney disease (pcy). Pcy is a recessive disorder causing chronic renal failure. The Pcy phenotype can be slowed by diet modification such as protein restriction, administration of soy-based proteins, administration of methylprednisolone or treatment with V2R antagonist. In contrast administration of bicarbonate/citrate has no effect.
uniprot
proteins
function
FUNCTION: Required for normal ciliary development and function. Inhibits disheveled-1-induced canonical Wnt-signaling activity and may also play a role in the control of non-canonical Wnt signaling that regulates planar cell polarity. Probably acts as a molecular switch between different Wnt signaling pathways. Required for proper convergent extension cell movements. {ECO:0000269|PubMed:18371931}.
uniprot
proteins
mass_dalton
150289
uniprot
proteins
pubmed
12872122
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18371931
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
1325
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}. Note=Localization to cilium is mediated via interaction with UNC119 and UNC119B, which bind to the myristoyl moiety of the N-terminus. {ECO:0000250}.
uniprot
proteins