Sord
entrez
24788
canonical
uniprot
P27867
canonical
ensembl
ENSRNOG00000017291
resolver
ensp
ENSRNOP00000084990
resolver
genesymbol
Sord
resolver
genesymbol_syn
Sdh1
resolver
uniprot
A2VCV9
resolver
uniprot
Q4FZY4
resolver
uniprot
Q5I0F3
resolver
uniprot_entry
DHSO_RAT
resolver
uniprot_sec
A2VCV9
resolver
uniprot_sec
Q4FZY4
resolver
uniprot_sec
Q5I0F3
resolver
amino_acid_sequence
MAAPAKGENLSLVVHGPGDIRLENYPIPELGPNDVLLKMHSVGICGSDVHYWEHGRIGDFVVKKPMVLGHEAAGTVTKVGPMVKHLKPGDRVAIEPGVPREIDEFCKIGRYNLTPSIFFCATPPDDGNLCRFYKHSADFCYKLPDSVTFEEGALIEPLSVGIYACRRGSVSLGNKVLVCGAGPIGIVTLLVAKAMGASQVVVIDLSASRLAKAKEVGADFTIQVAKETPHDIAKKVESVLGSKPEVTIECTGAESSVQTGIYATHSGGTLVVVGMGPEMINLPLVHAAVREVDIKGVFRYCNTWPMAVSMLASKTLNVKPLVTHRFPLEKAVEAFETAKKGLGLKVMIKCDPNDQNP
uniprot
proteins
ec_number
1.1.1.-
uniprot
proteins
ec_number
1.1.1.14
uniprot
proteins
ec_number
1.1.1.9
uniprot
proteins
function
FUNCTION: Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols (By similarity). Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose (PubMed:6862079). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (By similarity). {ECO:0000250|UniProtKB:Q00796, ECO:0000269|PubMed:6862079}.
uniprot
proteins
mass_dalton
38235
uniprot
proteins
protein_family
Zinc-containing alcohol dehydrogenase family
uniprot
proteins
pubmed
11306057
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2050152
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
6862079
uniprot
proteins
pubmed
8223590
uniprot
proteins
sequence_length
357
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250|UniProtKB:Q64442}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q64442}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q64442}. Note=Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface. {ECO:0000250|UniProtKB:Q64442}.
uniprot
proteins