Q9Z1K7
uniprot
Q9Z1K7
canonical
amino_acid_sequence
MTSSMASYEQLVRQVEALKAENTHLRQELRDNSSHLSKLETETSGMKEVLKHLQGKLEQEARVLVSSGQTEVLEQLKALQTDISSLYNLKFHAPALGPEPAARTPEGSPVHGSGPSKDSFGELSRATIRLLEELDQERCFLLSEIEKEEKEKLWYYSQLQGLSKRLDELPHVDTFSMQMDLIRQQLEFEAQHIRSLMEERFGTSDEMVQRAQIRASRLEQIDKELLEAQDRVQQTEPQALLAVKPVAVEEEQEAEVPTHPEDGTPQPGNSKVEVVFWLLSMLATRDQEDTARTLLAMSSSPESCVAMRRSGCLPLLLQILHGTEAGSVGRAGIPGAPGAKDARMRANAALHNIVFSQPDQGLARKEMRVLHVLEQIRAYCETCWDWLQARDSGTETPVPIEPQICQATCAVMKLSFDEEYRRAMNELGGLQAVAELLQVDYEMHKMTRDPLNLALRRYAGMTLTNLTFGDVANKATLCARRGCMEAIVAQLGSESEELHQVVSSILRNLSWRADINSKKVLREVGSMTALMECVLRASKESTLKSVLSALWNLSAHSTENKAAICQVDGALGFLVSTLTYRCQGNSLAVIESGGGILRNVSSLIATREDYRQVLRDHNCLQTLLQHLTSHSLTIVSNACGTLWNLSARSPRDQELLWDLGAVGMLRNLVHSKHKMIAMGSAAALRNLLAHRPAKYQAAAMAVSPGTCVPSLYVRKQRALEAELDTRHLVHALGHLEKQSLPEAETTSKKPLPPLRHLDGLVQDYASDSGCFDDDDAPSLAAAATTAEPASPAVMSMFLGGPFLQGQALARTPPARQGGLEAEKEAGGEAAVAAKAKAKLALAVARIDRLVEDISALHTSSDDSFSLSSGDPGQEAPREGRAQSCSPCRGTEGGRREAGSRAHPLLRLKAAHTSLSNDSLNSGSTSDGYCTREHMTPCPLAALAEHRDDPVRGQTRPRRLDLDLPSRAELPARDTAATDARVRTIKLSPTYQHVPLLDGAAGAGVRPLVGPGTSPGARKQAWIPADSLSKVPEKLVASPLPIASKVLQKLVAQDGPMSLSRCSSLSSLSSTGHAVPSQAENLDSDSSLEGLEEAGPGEAELGRAWRASGSTSLPVSIPAPQRGRSRGLGVEDATPSSSSENCVQETPLVLSRCSSVSSLGSFESRSIASSIPSDPCSGLGSGTVSPSELPDSPGQTMPPSRSKTPPAPPGQPETSQFSLQWESYVKRFLDIADCRERCQPPSELDAGSVRFTVEKPDENFSCASSLSALALHELYVQQDVELRLRPPACPERAVGGGGHRRRDEAASRLDGPAPAGSRARSATDKELEALRECLGAAMPARLRKVASALVPGRRSLPVPVYMLVPAPARGDDSGTDSAEGTPVNFSSAASLSDETLQGPSRDKPAGPGDRQKPTGRAAPARQTRSHRPKAAGAGKSTEHTRGPCRNRAGLELPLSRPQSARSNRDSSCQTRTRGDGALQSLCLTTPTEEAVYCFYDSDEEPPATAPPPRRASAIPRALKREKPAGRKETPSRAAQPATLPVRAQPRLIVDETPPCYSLTSSASSLSEPEAPEQPANHARGPEQGSKQDSSPSPRAEEELLQRCISLAMPRRRTQVPGSRRRKPRALRSDIRPTEITQKCQEEVAGSDPASDLDSVEWQAIQEGANSIVTWLHQAAAKASLEASSESDSLLSLVSGVSAGSTLQPSKLRKGRKPAAEAGGAWRPEKRGTTSTKINGSPRLPNGPEKAKGTQKMMAGESTMLRGRTVIYSAGPASRTQSKGISGPCTTPKKTGTSGTTQPETVTKAPSPEQQRSRSLHRPGKISELAALRHPPRSATPPARLAKTPSSSSSQTSPASQPLPRRSPLATPTGGPLPGPGGSLVPKSPARALLAKQHKTQKSPVRIPFMQRPARRVPPPLARPSPEPGSRGRAGAEGTPGARGSRLGLVRMASARSSGSESSDRSGFRRQLTFIKESPGLLRRRRSELSSADSTASTSQAASPRRGRPALPAVFLCSSRCDELRVSPRQPLAAQRSPQAKPGLAPLAPRRTSSESPSRLPVRASPGRPETVKRYASLPHISVSRRSDSAVSVPTTQANATRRGSDGEARPLPRVAPPGTTWRRIKDEDVPHILRSTLPATALPLRVSSPEDSPAGTPQRKTSDAVVQTEDVATSKTNSSTSPSLESRDPPQAPASGPVAPQGSDVDGPVLTKPPASAPFPHEGLSAVIAGFPTSRHGSPSRAARVPPFNYVPSPMAAATMASDSAVEKAPVSSPASLLE
uniprot
proteins
function
FUNCTION: Stabilizes microtubules and may regulate actin fiber dynamics through the activation of Rho family GTPases. May also function in Wnt signaling by promoting the rapid degradation of CTNNB1. {ECO:0000250|UniProtKB:O95996}.
uniprot
proteins
mass_dalton
243139
uniprot
proteins
protein_family
Adenomatous polyposis coli (APC) family
uniprot
proteins
pubmed
10021369
uniprot
proteins
pubmed
15018807
uniprot
proteins
pubmed
17310996
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25753423
uniprot
proteins
sequence_length
2274
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O95996}. Golgi apparatus {ECO:0000250|UniProtKB:O95996}. Cytoplasm {ECO:0000250|UniProtKB:O95996}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O95996}. Note=Associated with actin filaments. Associated with microtubule network. {ECO:0000250|UniProtKB:O95996}.
uniprot
proteins