CREB3L4
entrez
148327
canonical
uniprot
Q8TEY5
canonical
ensembl
ENSG00000143578
resolver
ensp
ENSP00000271889
resolver
ensp
ENSP00000357589
resolver
ensp
ENSP00000357592
resolver
ensp
ENSP00000357596
resolver
ensp
ENSP00000555188
resolver
ensp
ENSP00000555189
resolver
ensp
ENSP00000555190
resolver
ensp
ENSP00000555192
resolver
ensp
ENSP00000555196
resolver
ensp
ENSP00000600377
resolver
ensp
ENSP00000761525
resolver
genesymbol
CREB3L4
resolver
genesymbol_syn
AIBZIP
resolver
genesymbol_syn
CREB4
resolver
genesymbol_syn
JAL
resolver
hgnc
HGNC:18854
resolver
uniprot
D3DV62
resolver
uniprot
Q5T4L0
resolver
uniprot
Q86YW6
resolver
uniprot_entry
CR3L4_HUMAN
resolver
uniprot_sec
D3DV62
resolver
uniprot_sec
Q5T4L0
resolver
uniprot_sec
Q86YW6
resolver
amino_acid_sequence
MDLGIPDLLDAWLEPPEDIFSTGSVLELGLHCPPPEVPVTRLQEQGLQGWKSGGDRGCGLQESEPEDFLKLFIDPNEVYCSEASPGSDSGISEDPCHPDSPPAPRATSSPMLYEVVYEAGALERMQGETGPNVGLISIQLDQWSPAFMVPDSCMVSELPFDAHAHILPRAGTVAPVPCTTLLPCQTLFLTDEEKRLLGQEGVSLPSHLPLTKAEERVLKKVRRKIRNKQSAQDSRRRKKEYIDGLESRVAACSAQNQELQKKVQELERHNISLVAQLRQLQTLIAQTSNKAAQTSTCVLILLFSLALIILPSFSPFQSRPEAGSEDYQPHGVTSRNILTHKDVTENLETQVVESRLREPPGAKDANGSTRTLLEKMGGKPRPSGRIRSVLHADEM
uniprot
proteins
function
FUNCTION: Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements (By similarity). {ECO:0000250, ECO:0000269|PubMed:16236796}.
uniprot
proteins
mass_dalton
43432
uniprot
proteins
mutagenesis
MUTAGEN 335; /note="R->G: Abolishes cleavage by SP1."; /evidence="ECO:0000269|PubMed:16236796
uniprot
proteins
post_translational_modification
PTM: N-glycosylated in the C-terminal region. {ECO:0000269|PubMed:15938716}.; PTM: Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
ATF subfamily
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
pubmed
11830526
uniprot
proteins
pubmed
12111373
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15938716
uniprot
proteins
pubmed
16236796
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17270658
uniprot
proteins
sequence_length
395
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=May also be located in Golgi apparatus.; SUBCELLULAR LOCATION: [Processed cyclic AMP-responsive element-binding protein 3-like protein 4]: Nucleus. Note=Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 296..316; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins