Ehhadh
entrez
171142
canonical
uniprot
P07896
canonical
ensembl
ENSRNOG00000001770
resolver
ensp
ENSRNOP00000002410
resolver
enst
ENSRNOT00000002410
resolver
genesymbol
Ehhadh
resolver
genesymbol_syn
Mfe1
resolver
uniprot
Q5EBD2
resolver
uniprot_entry
ECHP_RAT
resolver
uniprot_sec
Q5EBD2
resolver
activity_regulation
ACTIVITY REGULATION: Enzyme activity enhanced by acetylation. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MAEYLRLPHSLAMIRLCNPPVNAVSPTVIREVRNGLQKAGSDHTVKAIVICGANGNFCAGADIHGFSAFTPGLALGSLVDEIQRYQKPVLAAIQGVALGGGLELALGCHYRIANAKARVGLPEVTLGILPGARGTQLLPRVVGVPVALDLITSGKYLSADEALRLGILDAVVKSDPVEEAIKFAQKIIDKPIEPRRIFNKPVPSLPNMDSVFAEAIAKVRKQYPGVLAPETCVRSIQASVKHPYEVGIKEEEKLFMYLRASGQAKALQYAFFAEKSANKWSTPSGASWKTASAQPVSSVGVLGLGTMGRGIAISFARVGISVVAVESDPKQLDAAKKIITFTLEKEASRAHQNGQASAKPKLRFSSSTKELSTVDLVVEAVFEDMNLKKKVFAELSALCKPGAFLCTNTSALNVDDIASSTDRPQLVIGTHFFSPAHVMRLLEVIPSRYSSPTTIATVMSLSKKIGKIGVVVGNCYGFVGNRMLAPYYNQGFFLLEEGSKPEDVDGVLEEFGFKMGPFRVSDLAGLDVGWKIRKGQGLTGPSLPPGTPVRKRGNSRYSPLGDMLCEAGRFGQKTGKGWYQYDKPLGRIHKPDPWLSTFLSQYREVHHIEQRTISKEEILERCLYSLINEAFRILEEGMAARPEHIDVIYLHGYGWPRHKGGPMFYAASVGLPTVLEKLQKYYRQNPDIPQLEPSDYLRRLVAQGSPPLKEWQSLAGPHGSKL
uniprot
proteins
ec_number
1.1.1.35
uniprot
proteins
ec_number
4.2.1.17
uniprot
proteins
ec_number
5.3.3.8
uniprot
proteins
function
FUNCTION: Peroxisomal trifunctional enzyme possessing 2-enoyl-CoA hydratase, 3-hydroxyacyl-CoA dehydrogenase, and delta 3, delta 2-enoyl-CoA isomerase activities (PubMed:12106015, PubMed:2303409, PubMed:23351063). Catalyzes two of the four reactions of the long chain fatty acids peroxisomal beta-oxidation pathway (PubMed:12106015, PubMed:2303409). Can also use branched-chain fatty acids such as 2-methyl-2E-butenoyl-CoA as a substrate, which is hydrated into (2S,3S)-3-hydroxy-2-methylbutanoyl-CoA (Probable). Optimal isomerase for 2,5 double bonds into 3,5 form isomerization in a range of enoyl-CoA species. Also able to isomerize both 3-cis and 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species (PubMed:11781327). Regulates the amount of medium-chain dicarboxylic fatty acids which are essential regulators of all fatty acid oxidation pathways (By similarity). Also involved in the degradation of long-chain dicarboxylic acids through peroxisomal beta-oxidation (By similarity). {ECO:0000250|UniProtKB:Q08426, ECO:0000250|UniProtKB:Q9DBM2, ECO:0000269|PubMed:11781327, ECO:0000269|PubMed:12106015, ECO:0000269|PubMed:2303409, ECO:0000305|PubMed:23351063}.
uniprot
proteins
mass_dalton
78658
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid beta-oxidation. {ECO:0000269|PubMed:11781327, ECO:0000269|PubMed:12106015, ECO:0000269|PubMed:2303409}.
uniprot
proteins
post_translational_modification
PTM: Acetylated, leading to enhanced enzyme activity. Acetylation is enhanced by up to 80% after treatment either with trichostin A (TCA) or with nicotinamide (NAM) with highest increase on Lys-345. Acetylation and enzyme activity increased by about 1.5% on addition of fatty acids (By similarity). {ECO:0000250|UniProtKB:Q08426}.
uniprot
proteins
protein_family
Enoyl-CoA hydratase/isomerase family; 3-hydroxyacyl-CoA dehydrogenase family
uniprot
proteins
pubmed
11781327
uniprot
proteins
pubmed
12106015
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16330050
uniprot
proteins
pubmed
2303409
uniprot
proteins
pubmed
23351063
uniprot
proteins
pubmed
3036802
uniprot
proteins
pubmed
4019459
uniprot
proteins
pubmed
8856068
uniprot
proteins
sequence_length
722
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:11781327}.
uniprot
proteins