Igfbp5
entrez
16011
canonical
uniprot
Q07079
canonical
ensembl
ENSMUSG00000026185
resolver
ensp
ENSMUSP00000027377
resolver
enst
ENSMUST00000027377
resolver
genesymbol
Igfbp5
resolver
genesymbol_syn
Igfbp-5
resolver
uniprot
Q3UQV0
resolver
uniprot_entry
IBP5_MOUSE
resolver
uniprot_entry
Q3UQV0_MOUSE
resolver
amino_acid_sequence
MVISVVLLLLAAYAVPAQGLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYGEQTKIERDSREHEEPTTSEMAEETYSPKVFRPKHTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVIPAPEMRQESEQGPCRRHMEASLQEFKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHAFDSSNVE
uniprot
proteins
function
FUNCTION: Multifunctional protein that plays a critical role in regulating the availability of IGFs to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner. Increases the cell proliferation of osteoblasts, intestinal smooth muscle cells and neuroblastoma cells (By similarity). Enhances adhesion and survival of epithelial cells but decreases adhesion of mesenchymal cells (PubMed:24120850). Once secreted, acts as a major mediator of mTORC1-dependent feedback inhibition of IGF1 signaling (By similarity). Also plays a role in the induction of extracellular matrix (ECM) production and deposition independently of its nuclear translocation and binding to IGFs. Acts itself as a growth factor that can act independently of IGFs to regulate bone formation. Acts as a ligand for the ROR1 receptor which triggers formation of ROR1/HER2 heterodimer to enhance CREB oncogenic signaling (By similarity). {ECO:0000250|UniProtKB:P24593, ECO:0000269|PubMed:24120850}.
uniprot
proteins
mass_dalton
30372
uniprot
proteins
pubmed
15010534
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24120850
uniprot
proteins
pubmed
26854565
uniprot
proteins
pubmed
7518410
uniprot
proteins
pubmed
7529732
uniprot
proteins
pubmed
7693664
uniprot
proteins
sequence_length
271
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:26854565}. Cytoplasm {ECO:0000250|UniProtKB:P24593}. Nucleus {ECO:0000250|UniProtKB:P24593}.
uniprot
proteins