Bmp2
entrez
12156
canonical
uniprot
P21274
canonical
ensembl
ENSMUSG00000027358
resolver
ensp
ENSMUSP00000028836
resolver
enst
ENSMUST00000028836
resolver
genesymbol
Bmp2
resolver
genesymbol_syn
Bmp-2
resolver
uniprot
Q497W8
resolver
uniprot_entry
BMP2_MOUSE
resolver
uniprot_sec
Q497W8
resolver
amino_acid_sequence
MVAGTRCLLVLLLPQVLLGGAAGLIPELGRKKFAAASSRPLSRPSEDVLSEFELRLLSMFGLKQRPTPSKDVVVPPYMLDLYRRHSGQPGAPAPDHRLERAASRANTVRSFHHEEAVEELPEMSGKTARRFFFNLSSVPSDEFLTSAELQIFREQIQEALGNSSFQHRINIYEIIKPAAANLKFPVTRLLDTRLVNQNTSQWESFDVTPAVMRWTTQGHTNHGFVVEVAHLEENPGVSKRHVRISRSLHQDEHSWSQIRPLLVTFGHDGKGHPLHKREKRQAKHKQRKRLKSSCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCHGECPFPLADHLNSTNHAIVQTLVNSVNSKIPKACCVPTELSAISMLYLDENEKVVLKNYQDMVVEGCGCR
uniprot
proteins
function
FUNCTION: Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including cardiogenesis, neurogenesis, and osteogenesis. Induces cartilage and bone formation. Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Also acts to promote expression of HAMP, via the interaction with its receptor BMPR1A/ALK3 (PubMed:31800957). Can also signal through non-canonical pathways such as ERK/MAP kinase signaling cascade that regulates osteoblast differentiation. Also stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A-ATF4 pathway by stimulating EIF2A phosphorylation which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (PubMed:29148101). {ECO:0000250|UniProtKB:P12643, ECO:0000269|PubMed:29148101, ECO:0000269|PubMed:31800957}.
uniprot
proteins
mass_dalton
44525
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
14623234
uniprot
proteins
pubmed
15039429
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15671031
uniprot
proteins
pubmed
15975920
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16604073
uniprot
proteins
pubmed
17472960
uniprot
proteins
pubmed
17522060
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
1970330
uniprot
proteins
pubmed
23963447
uniprot
proteins
pubmed
24028588
uniprot
proteins
pubmed
29148101
uniprot
proteins
pubmed
29198724
uniprot
proteins
pubmed
31800957
uniprot
proteins
pubmed
8018727
uniprot
proteins
sequence_length
394
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins