Banp
entrez
53325
canonical
uniprot
Q8VBU8
canonical
ensembl
ENSMUSG00000025316
resolver
ensp
ENSMUSP00000026354
resolver
ensp
ENSMUSP00000090766
resolver
ensp
ENSMUSP00000132095
resolver
ensp
ENSMUSP00000132434
resolver
ensp
ENSMUSP00000133783
resolver
ensp
ENSMUSP00000168861
resolver
ensp
ENSMUSP00000168868
resolver
ensp
ENSMUSP00000168882
resolver
ensp
ENSMUSP00000330444
resolver
genesymbol
Banp
resolver
genesymbol_syn
Smar1
resolver
uniprot
O88973
resolver
uniprot
Q3U4R5
resolver
uniprot
Q91YZ1
resolver
uniprot
Q9ES51
resolver
uniprot_entry
BANP_MOUSE
resolver
uniprot_sec
O88973
resolver
uniprot_sec
Q3U4R5
resolver
uniprot_sec
Q91YZ1
resolver
uniprot_sec
Q9ES51
resolver
amino_acid_sequence
MMSEQDLADVVQIAVEDLSPDHPVVLENHVVTDDDEPALKRQRLEINCQDPSIKSFLYSINQTICLRLDSIEAKLQALEATCKSLEEKLDLVTNKQHSPIQVPMVAGSPLGATQTCNKVRCVVPQTTVILNNDRQNAIVAKMEDPLSNRAPDSLENIISNAVPGRRQNTIVVKVPGQDDSHNEDGESGSEASDSVSNCGQPGSQNIGSNVTLITLNSEEDYPNGTWLGDENNPEMRVRCAIIPSDMLHISTNCRTAEKMALTLLDYLFHREVQAVSNLSGQGKHGKKQLDPLTIYGIRCHLFYKFGITESDWYRIKQSIDSKCRTAWRRKQRGQSLAVKSFSRRTPSSSSYSASETMMGTPPPTSELQQSQPQALHYALANAQQVQIHQIGEDGQVQVIPQGHLHIAQVPQGEQVQITQDSEGNLQIHHVGQDGQSWGLCQNPIPVSGDSVAQANPSQLWPLGGDTLDLPAGNEMIQVLQGAQLIAVASSDPAATGVDGSPLQGSDIQVQYVQLAPVSDHTAAAQTAEALQPTLQPDMQLEHGAIQIQ
uniprot
proteins
function
FUNCTION: Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function (PubMed:10950932, PubMed:12494467, PubMed:15623522). Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer (PubMed:10950932, PubMed:15371550). Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels (PubMed:16166625). Promotes TP53 activation, which causes cell cycle arrest and inhibits tumor growth (PubMed:12494467, PubMed:17229733). Plays a role in the regulation of alternative splicing (By similarity). Binds to CD44 pre-mRNA and negatively regulates the inclusion of CD44 proximal variable exons v2-v6 but has no effect on distal variable exons v7-v10 (By similarity). {ECO:0000250|UniProtKB:Q8N9N5, ECO:0000269|PubMed:10950932, ECO:0000269|PubMed:12494467, ECO:0000269|PubMed:15371550, ECO:0000269|PubMed:15623522, ECO:0000269|PubMed:16166625, ECO:0000269|PubMed:17229733}.
uniprot
proteins
mass_dalton
59657
uniprot
proteins
mutagenesis
MUTAGEN 345; /note="T->A: Reduces phosphorylation and abolishes cytoplasmic localization; when associated with A-360."; /evidence="ECO:0000269|PubMed:26080397"; MUTAGEN 347; /note="S->A: Impairs TP53 activation."; /evidence="ECO:0000269|PubMed:17229733"; MUTAGEN 348; /note="S->A: No effect on TP53 activation."; /evidence="ECO:0000269|PubMed:17229733"; MUTAGEN 349; /note="S->A: No effect on TP53 activation."; /evidence="ECO:0000269|PubMed:17229733"; MUTAGEN 350; /note="S->A: No effect on TP53 activation."; /evidence="ECO:0000269|PubMed:17229733"; MUTAGEN 360; /note="T->A: Reduces phosphorylation and abolishes cytoplasmic localization; when associated with A-345."; /evidence="ECO:0000269|PubMed:26080397
uniprot
proteins
post_translational_modification
PTM: MAPK1/MAPK3-mediated phosphorylation at Thr-345 and Thr-360 results in export to the cytoplasm. {ECO:0000269|PubMed:26080397}.
uniprot
proteins
protein_family
BANP/SMAR1 family
uniprot
proteins
pubmed
10940556
uniprot
proteins
pubmed
10950932
uniprot
proteins
pubmed
12494467
uniprot
proteins
pubmed
15371550
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15623522
uniprot
proteins
pubmed
15701641
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16166625
uniprot
proteins
pubmed
17229733
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
26080397
uniprot
proteins
pubmed
32144153
uniprot
proteins
sequence_length
548
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10940556, ECO:0000269|PubMed:12494467, ECO:0000269|PubMed:15371550, ECO:0000269|PubMed:16166625}. Nucleus speckle {ECO:0000250|UniProtKB:Q8N9N5}. Cytoplasm {ECO:0000250|UniProtKB:Q8N9N5}. Note=Primarily nuclear but translocates to the cytoplasm following MAPK1/MAPK3-mediated phosphorylation. {ECO:0000250|UniProtKB:Q8N9N5}.
uniprot
proteins