Bcar1
entrez
25414
canonical
uniprot
Q63767
canonical
ensembl
ENSRNOG00000019253
resolver
ensp
ENSRNOP00000039940
resolver
ensp
ENSRNOP00000055678
resolver
enst
ENSRNOT00000041815
resolver
enst
ENSRNOT00000058891
resolver
genesymbol
Bcar1
resolver
genesymbol_syn
Cas
resolver
genesymbol_syn
Crkas
resolver
uniprot
D3ZE30
resolver
uniprot
F1LVA8
resolver
uniprot
Q63766
resolver
uniprot_entry
BCAR1_RAT
resolver
uniprot_entry
D3ZE30_RAT
resolver
uniprot_entry
F1LVA8_RAT
resolver
uniprot_sec
Q63766
resolver
amino_acid_sequence
MKYLVSVGAGPARRAGGLEDVSWGPRVSRRPQSYRAARHVNESLPRSAFRVPAAHGASVTPSAALGSGLPETQPEAVCRGTEKPRFAEGCKPAASRDKNVLAKALYDNVAESPDELSFRKGDIMTVLERDTQGLDGWWLCSLHGRQGIVPGNRLKILVGMYDKKPAAPGPGPPATPPQPQPSLPQGVHTPVPPASQYSPMLPTAYQPQPDNVYLVPTPSKTQQGLYQAPGPNPQFQSPPAKQTSTFSKQTPHHSFPSPATDLYQVPPGPGSPAQDIYQVPPSAGTGHDIYQVPPSLDTRSWEGTKPPAKVVVPTRVGQGYVYEASQAEQDEYDTPRHLLAPGSQDIYDVPPVRGLLPNQYGQEVYDTPPMAVKGPNGRDPLLDVYDVPPSVEKGLPPSNHHSVYDVPPSVSKDVPDGPLLREETYDVPPAFAKPKPFDPTRHPLILAAPPPDSPPAEDVYDVPPPAPDLYDVPPGLRRPGPGTLYDVPRERVLPPEVADGSVIDDGVYAVPPPAEREAPTDGKRLSASSTGSTRSSQSASSLEVVVPGREPLELEVAVETLARLQQGVSTTVAHLLDLVGSASGPGGWRSTSEPQEPPVQDLKAAVAAVHGAVHELLEFARSAVSSATHTSDRTLHAKLSRQLQKMEDVYQTLVVHGQVLDSGRGGPGFTLDDLDRLVACSRAVPEDAKQLASFLHGNASLLFRRTKAPGPGPEGSSSLHLNPTDKASSIQSRPLPSPPKFTSQDSPDGQYENSEGGWMEDYDYVHLQGKEEFEKTQKELLEKGNIVRQGKGQLELQQLKQFERLEQEVSRPIDHDLANWTPAQPLVPGRTGGLGPSDRQLLLFYLEQCEANLTTLTDAVDAFFTAVATNQPPKIFVAHSKFVILSAHKLVFIGDTLSRQAKAADVRSKVTHYSNLLCDLLRGIVATTKAAALQYPSPSAAQDMVDRVKELGHSTQQFRRVLGQLAAA
uniprot
proteins
function
FUNCTION: Docking protein which plays a central coordinating role for tyrosine-kinase-based signaling related to cell adhesion (By similarity). Implicated in induction of cell migration and cell branching (By similarity). Involved in the BCAR3-mediated inhibition of TGFB signaling (By similarity). {ECO:0000250|UniProtKB:P56945, ECO:0000250|UniProtKB:Q61140}.
uniprot
proteins
mass_dalton
104262
uniprot
proteins
post_translational_modification
PTM: PTK2/FAK1 activation mediates phosphorylation at the YDYVHL motif; phosphorylation is most likely catalyzed by SRC family members. SRC-family kinases are recruited to the phosphorylated sites and can phosphorylate other tyrosine residues. Tyrosine phosphorylation is triggered by integrin mediated adhesion of cells to the extracellular matrix. {ECO:0000269|PubMed:7780740, ECO:0000269|PubMed:9360983}.; PTM: Phosphorylated by SRC kinase in a EDN1- and PTK2B-mediated manner; phosphorylation strengthens its interaction with BCAR3 as part of the PTK2B/BCAR1/BCAR3/RAP1 signaling pathway. {ECO:0000250|UniProtKB:P56945}.; PTM: Dephosphorylated by PTPN14 at Tyr-226. {ECO:0000250}.
uniprot
proteins
protein_family
CAS family
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7780740
uniprot
proteins
pubmed
8070403
uniprot
proteins
pubmed
9360983
uniprot
proteins
sequence_length
968
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q61140}. Cytoplasm {ECO:0000250|UniProtKB:Q61140}. Cell projection, axon {ECO:0000250|UniProtKB:Q61140}. Note=Unphosphorylated form localizes in the cytoplasm (By similarity). Localizes to focal adhesion sites following integrin engagement (By similarity). {ECO:0000250|UniProtKB:Q61140}.
uniprot
proteins