TXNIP
entrez
10628
canonical
uniprot
Q9H3M7
canonical
ensembl
ENSG00000265972
resolver
ensp
ENSP00000396322
resolver
ensp
ENSP00000462521
resolver
genesymbol
TXNIP
resolver
genesymbol_syn
VDUP1
resolver
hgnc
HGNC:16952
resolver
uniprot
B4E3D3
resolver
uniprot
Q16226
resolver
uniprot
Q6PML0
resolver
uniprot
Q9BXG9
resolver
uniprot_entry
TXNIP_HUMAN
resolver
uniprot_sec
B4E3D3
resolver
uniprot_sec
Q16226
resolver
uniprot_sec
Q6PML0
resolver
uniprot_sec
Q9BXG9
resolver
amino_acid_sequence
MVMFKKIKSFEVVFNDPEKVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLWMQGSQQCKQTSEYLRYEDTLLLEDQPTGENEMVIMRPGNKYEYKFGFELPQGPLGTSFKGKYGCVDYWVKAFLDRPSQPTQETKKNFEVVDLVDVNTPDLMAPVSAKKEKKVSCMFIPDGRVSVSARIDRKGFCEGDEISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVLTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILRVEYSLLIYVSVPGSKKVILDLPLVIGSRSGLSSRTSSMASRTSSEMSWVDLNIPDTPEAPPCYMDVIPEDHRLESPTTPLLDDMDGSQDSPIFMYAPEFKFMPPPTYTEVDPCILNNNVQ
uniprot
proteins
function
FUNCTION: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability (PubMed:17603038). Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest (PubMed:12821938). Required for the maturation of natural killer cells (By similarity). Acts as a suppressor of tumor cell growth (PubMed:18541147). Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (PubMed:21460850). {ECO:0000250|UniProtKB:Q8BG60, ECO:0000269|PubMed:12821938, ECO:0000269|PubMed:17603038, ECO:0000269|PubMed:18541147, ECO:0000269|PubMed:21460850}.
uniprot
proteins
mass_dalton
43661
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; undergoes heterotypic 'Lys-48'-/'Lys-63'-branched polyubiquitination catalyzed by ITCH and UBR5 resulting in proteasomal degradation (PubMed:29378950). Deubiquitinated by USP5, leading to TXNIP stabilization (PubMed:37534934). {ECO:0000269|PubMed:20068034, ECO:0000269|PubMed:29378950, ECO:0000269|PubMed:37534934}.
uniprot
proteins
protein_family
Arrestin family
uniprot
proteins
pubmed
12821938
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17603038
uniprot
proteins
pubmed
18541147
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068034
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21460850
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23519408
uniprot
proteins
pubmed
29378950
uniprot
proteins
pubmed
37534934
uniprot
proteins
pubmed
8086474
uniprot
proteins
sequence_length
391
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:37534934}. Nucleus {ECO:0000269|PubMed:37534934}.
uniprot
proteins