Ebf1
entrez
13591
canonical
uniprot
Q07802
canonical
ensembl
ENSMUSG00000057098
resolver
ensp
ENSMUSP00000080020
resolver
ensp
ENSMUSP00000099857
resolver
ensp
ENSMUSP00000104891
resolver
enst
ENSMUST00000101326
resolver
enst
ENSMUST00000109268
resolver
genesymbol
Ebf1
resolver
genesymbol_syn
Coe1
resolver
genesymbol_syn
Ebf
resolver
uniprot
Q3URW4
resolver
uniprot
Q3UTW6
resolver
uniprot
Q5SWK4
resolver
uniprot
Q5SWK5
resolver
uniprot
Q5SWK8
resolver
uniprot
Q8CBL7
resolver
uniprot_entry
COE1_MOUSE
resolver
uniprot_entry
Q3URW4_MOUSE
resolver
uniprot_entry
Q3UTW6_MOUSE
resolver
uniprot_entry
Q5SWK4_MOUSE
resolver
uniprot_entry
Q5SWK5_MOUSE
resolver
uniprot_entry
Q5SWK8_MOUSE
resolver
uniprot_entry
Q8CBL7_MOUSE
resolver
amino_acid_sequence
MFGIQESIQRSGSSMKEEPLGSGMNAVRTWMQGAGVLDANTAAQSGVGLARAHFEKQPPSNLRKSNFFHFVLALYDRQGQPVEIERTAFVGFVEKEKEANSEKTNNGIHYRLQLLYSNGIRTEQDFYVRLIDSMTKQAIVYEGQDKNPEMCRVLLTHEIMCSRCCDKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVVSTTVNVDGHVLAVSDNMFVHNNSKHGRRARRLDPSEGTPSYLEHATPCIKAISPSEGWTTGGATVIIIGDNFFDGLQVIFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGRFIYTALNEPTIDYGFQRLQKVIPRHPGDPERLPKEVILKRAADLVEALYGMPHNNQEIILKRAADIAEALYSVPRNHNQLPALANTSVHAGMMGVNSFSGQLAVNVSEASQATNQGFTRNSSSVSPHGYVPSTTPQQTNYNSVTTSMNGYGSAAMSNLGGSPTFLNGSAANSPYAIVPSSPTMASSTSLPSNCSSSSGIFSFSPANMVSAVKQKSAFAPVVRPQTSPPPTCTSTNGNSLQAISGMIVPPM
uniprot
proteins
function
FUNCTION: Key pioneer transcription factor of B-cell specification and commitment (PubMed:1915300, PubMed:23812095, PubMed:7542362). Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (PubMed:20876732). Operates in a transcription factor network to activate B-cell-specific genes and repress genes associated with alternative cell fates (PubMed:20451411, PubMed:23812095). For instance, positively regulates many B-cell specific genes including BCR or CD40 while repressing genes that direct cells into alternative lineages, including GATA3 and TCF7 for the T-cell lineage (PubMed:20451411, PubMed:23812095). In addition to its role during lymphopoiesis, controls the thermogenic gene program in adipocytes during development and in response to environmental cold (PubMed:32130892). {ECO:0000269|PubMed:1915300, ECO:0000269|PubMed:20451411, ECO:0000269|PubMed:20876732, ECO:0000269|PubMed:23812095, ECO:0000269|PubMed:32130892, ECO:0000269|PubMed:7542362}.
uniprot
proteins
mass_dalton
64464
uniprot
proteins
mutagenesis
MUTAGEN 63; /note="R->A: Strongly reduced interaction with DNA."; /evidence="ECO:0000269|PubMed:20876732"; MUTAGEN 66; /note="N->A: Reduced interaction with DNA."; /evidence="ECO:0000269|PubMed:20876732"; MUTAGEN 163; /note="R->A: Strongly reduced interaction with DNA."; /evidence="ECO:0000269|PubMed:20876732"; MUTAGEN 203; /note="G->E: Strongly reduced interaction with DNA."; /evidence="ECO:0000269|PubMed:20876732"; MUTAGEN 235; /note="H->A: Strongly reduced interaction with DNA."; /evidence="ECO:0000269|PubMed:20876732
uniprot
proteins
protein_family
COE family
uniprot
proteins
pubmed
1915300
uniprot
proteins
pubmed
20451411
uniprot
proteins
pubmed
20876732
uniprot
proteins
pubmed
23812095
uniprot
proteins
pubmed
32130892
uniprot
proteins
pubmed
7542362
uniprot
proteins
pubmed
8491377
uniprot
proteins
pubmed
8497258
uniprot
proteins
pubmed
9151732
uniprot
proteins
sequence_length
591
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:1915300}.
uniprot
proteins