Bin1
entrez
117028
canonical
uniprot
O08839
canonical
ensembl
ENSRNOG00000012852
resolver
ensembl
ENSRNOG00055025882
resolver
ensembl
ENSRNOG00060028505
resolver
ensembl
ENSRNOG00065011904
resolver
ensp
ENSRNOP00000017573
resolver
ensp
ENSRNOP00000040191
resolver
ensp
ENSRNOP00000042320
resolver
ensp
ENSRNOP00000077086
resolver
ensp
ENSRNOP00000087136
resolver
ensp
ENSRNOP00000094103
resolver
ensp
ENSRNOP00000097221
resolver
ensp
ENSRNOP00000100862
resolver
ensp
ENSRNOP00000101123
resolver
enst
ENSRNOT00000096264
resolver
enst
ENSRNOT00000105880
resolver
enst
ENSRNOT00000111732
resolver
enst
ENSRNOT00000119810
resolver
enst
ENSRNOT00000127521
resolver
enst
ENSRNOT00000136210
resolver
genesymbol
Bin1
resolver
genesymbol_syn
Amph2
resolver
genesymbol_syn
Amphl
resolver
uniprot
A0A8I5Y9B3
resolver
uniprot
A0A8I6A3N4
resolver
uniprot
A0A8I6ANM7
resolver
uniprot
A0A8I6AU27
resolver
uniprot
A0ABK0L9U3
resolver
uniprot
A0ABK0LG93
resolver
uniprot
D4ACI3
resolver
uniprot
Q5HZA7
resolver
uniprot_entry
A0A8I5Y9B3_RAT
resolver
uniprot_entry
A0A8I6A3N4_RAT
resolver
uniprot_entry
A0A8I6ANM7_RAT
resolver
uniprot_entry
A0A8I6AU27_RAT
resolver
uniprot_entry
A0ABK0L9U3_RAT
resolver
uniprot_entry
A0ABK0LG93_RAT
resolver
uniprot_entry
BIN1_RAT
resolver
uniprot_entry
Q5HZA7_RAT
resolver
uniprot_sec
D4ACI3
resolver
amino_acid_sequence
MAEMGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASVKAMHEASKKLSECLQEVYEPEWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQTAKKKDEAKIAKPVSLLEKAAPQWCQGKLQAHLVAQTNLLRNQAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVSLEKQHGSNTFTVKAQPSDSAPEKGNKSPSPPPDGSPAATPEIRVNHEPEPASGASPGATIPKSPSQLRKGPPVPPPPKHTPSKEMKQEQILSLFDDAFVPEISVTTPSQFEAPGPFSEQASLLDLDFEPLPPVASPVKAPTPSGQSIPWDLWEPTESQAGVLPSGEPSSAEGSFAVAWPSQTAEPGPAQPAEASEVVGGTQEPGETAASEATSSSLPAVVVETFSATVNGAVEGSTTTGRLDLPPGFMFKVQAQHDYTATDTDELQLKAGDVVLVIPFQNPEEQDEGWLMGVKESDWNQHKELEKCRGVFPENFTERVQ
uniprot
proteins
function
FUNCTION: Is a key player in the control of plasma membrane curvature, and membrane shaping and remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (By similarity). Is a negative regulator of endocytosis (PubMed:27760323, PubMed:9736607). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (By similarity). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (PubMed:27760323). May be involved in the regulation of MYC activity and the control cell proliferation (By similarity). {ECO:0000250|UniProtKB:O00499, ECO:0000250|UniProtKB:O08539, ECO:0000269|PubMed:27760323, ECO:0000269|PubMed:9736607}.
uniprot
proteins
mass_dalton
64533
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by protein kinase C.
uniprot
proteins
pubmed
10380931
uniprot
proteins
pubmed
10430869
uniprot
proteins
pubmed
16516836
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
27760323
uniprot
proteins
pubmed
9182667
uniprot
proteins
pubmed
9280305
uniprot
proteins
pubmed
9341169
uniprot
proteins
pubmed
9348539
uniprot
proteins
pubmed
9736607
uniprot
proteins
sequence_length
588
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O08539}. Cytoplasm {ECO:0000250|UniProtKB:O08539}. Endosome {ECO:0000250|UniProtKB:O08539}. Cell membrane, sarcolemma, T-tubule {ECO:0000269|PubMed:9182667}.
uniprot
proteins