SHC4
entrez
399694
canonical
uniprot
Q6S5L8
canonical
ensembl
ENSG00000185634
resolver
ensp
ENSP00000329668
resolver
ensp
ENSP00000379786
resolver
ensp
ENSP00000443300
resolver
enst
ENST00000537958
resolver
genesymbol
SHC4
resolver
genesymbol_syn
SHCD
resolver
hgnc
HGNC:16743
resolver
uniprot
F5H5M1
resolver
uniprot
Q6UXQ3
resolver
uniprot
Q8IYW3
resolver
uniprot_entry
F5H5M1_HUMAN
resolver
uniprot_entry
SHC4_HUMAN
resolver
uniprot_sec
Q6UXQ3
resolver
uniprot_sec
Q8IYW3
resolver
amino_acid_sequence
MRERGQDSLAGLVLYVGLFGHPGMLHRAKYSRFRNESITSLDEGSSGGSVGNKGSPQPPHPALAPHLPTEDATLPSQESPTPLCTLIPRMASMKLANPATLLSLKNFCLGTKEVPRLKLQESRDPGSSGPSSPETSLSRSGTAPPPQQDLVGHRATALTPDSCPLPGPGEPTLRSRQDRHFLQHLLGMGMNYCVRYMGCVEVLQSMRSLDFGMRTQVTREAISRLCEAVPGANGAIKKRKPPVKFLSTVLGKSNLQFSGMNIKLTISTCSLTLMNLDNQQIIANHHMQSISFASGGDPDTTDYVAYVAKDPVNQRACHILECHNGMAQDVISTIGQAFELRFKQYLKNPSLNTSCESEEVHIDSHAEEREDHEYYNEIPGKQPPVGGVSDMRIKVQATEQMAYCPIQCEKLCYLPGNSKCSSVYENCLEQSRAIGNVHPRGVQSQRDTSLLKHTCRVDLFDDPCYINTQALQSTPGSAGNQRSAQPLGSPWHCGKAPETVQPGATAQPASSHSLPHIKQQLWSEECYHGKLSRKAAESLLVKDGDFLVRESATSPGQYVLSGLQGGQAKHLLLVDPEGKVRTKDHVFDNVGHLIRYHMDNSLPIISSGSEVSLKQPVRKDNNPALLHSNK
uniprot
proteins
function
FUNCTION: Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1. {ECO:0000269|PubMed:17409413}.
uniprot
proteins
mass_dalton
68785
uniprot
proteins
mutagenesis
MUTAGEN 315; /note="R->Q: Phosphorylation is markedly decreased. Completely reduces the phosphorylation and interaction with MUSK; when associated with K-549."; /evidence="ECO:0000269|PubMed:17452444"; MUTAGEN 374..375; /note="YY->F: Remains phosphorylated. Contains a residual phosphorylation; when associated with F-465. Retains the ability to bind MUSK. Reduced the phosphorylation in presence of MUSK; when associated with F-424 and F-465. Completely abolishes the phosphorylation in presence of MUSK; when associated with F-403; F-413; F-424 and F-465. Retains the ability to bind MUSK; when associated with F-465. Retains the ability to bind MUSK; when associated with F-424 and F-465. Retains the ability to bind MUSK; when associated with F-403; F-413; F-424 and F-465."; /evidence="ECO:0000269|PubMed:17452444"; MUTAGEN 403; /note="Y->F: Completely abolishes the phosphorylation in presence of MUSK; when associated with 374-F-F-375; F-413; F-424 and F-465."; /evidence="ECO:0000269|PubMed:17452444"; MUTAGEN 413; /note="Y->F: Completely abolishes the phosphorylation in presence of MUSK; when associated with 374-F-F-375; F-403; F-424 and F-465."; /evidence="ECO:0000269|PubMed:17452444"; MUTAGEN 424; /note="Y->F: Significantly decreased GRB2 interaction. Reduced the phosphorylation in presence of MUSK; when associated with 374-F-F-375 and F-465. Completely abolishes the phosphorylation in presence of MUSK; when associated with 374-F-F-375; F-403; F-413 and F-465."; /evidence="ECO:0000269|PubMed:17452444"; MUTAGEN 465; /note="Y->F: Remains phosphorylated. Contains a residual phosphorylation; when associated with 374-F-F-375. Reduced the phosphorylation in presence of MUSK; when associated with 374-F-F-375 and 424. Completely abolishes the phosphorylation in presence of MUSK; when associated with 374-F-F-375; F-403; F-413 and F-424. Retains the ability to bind MUSK. Retains the ability to bind MUSK; when associated with 374-F-F-375. Retains the ability to bind MUSK; when associated with 374-F-F-375 and F-424. Retains the ability to bind MUSK; when associated with 374-F-F-375; F-403; F-413 and F-424."; /evidence="ECO:0000269|PubMed:17452444"; MUTAGEN 549; /note="R->K: Completely reduces the phosphorylation and interaction with MUSK; when associated with Q-315."; /evidence="ECO:0000269|PubMed:17452444
uniprot
proteins
post_translational_modification
PTM: Phosphorylated; the phosphorylation is enhanced by EGF. Phosphorylation at Tyr-424 is required for the interaction with GRB2. {ECO:0000269|PubMed:17452444}.
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17409413
uniprot
proteins
pubmed
17452444
uniprot
proteins
sequence_length
630
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane. Note=Colocalized with MUSK at the neuromuscular junction. {ECO:0000250}.
uniprot
proteins