Slc7a5
entrez
20539
canonical
uniprot
Q9Z127
canonical
ensembl
ENSMUSG00000040010
resolver
ensp
ENSMUSP00000041557
resolver
enst
ENSMUST00000045557
resolver
genesymbol
Slc7a5
resolver
genesymbol_syn
Lat1
resolver
uniprot
Q8R0X8
resolver
uniprot
Q9JMI4
resolver
uniprot_entry
LAT1_MOUSE
resolver
uniprot_sec
Q8R0X8
resolver
uniprot_sec
Q9JMI4
resolver
activity_regulation
ACTIVITY REGULATION: Leucine uptake was inhibited by ileum, valine histidine and phenylalanine as well as by 2-amino-bicyclo-(2,2,1)-heptane-2-carboxylate (BCH) (a specific inhibitor of system L transport). {ECO:0000269|PubMed:9915839}.
uniprot
proteins
amino_acid_sequence
MAVAGAKRRAVATPAAAAAEEERQAREKMLEARRGDGADPEGEGVTLQRNITLLNGVAIIVGTIIGSGIFVTPTGVLKEAGSPGLSLVVWAVCGVFSIVGALCYAELGTTISKSGGDYAYMLEVYGSLPAFLKLWIELLIIRPSSQYIVALVFATYLLKPVFPTCPVPEEAAKLVACLCVLLLTAVNCYSVKAATRVQDAFAAAKLLALALIILLGFIQMGKDMGQGDASNLQQKLSFEGTNLDVGNIVLALYSGLFAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTLSTNQMLTSEAVAVDFGNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLPSVLSMIHPQLLTPVPSLVFTCIMTLMYAFSRDIFSIINFFSFFNWLCVALAIIGMMWLRFKKPELERPIKVNLALPVFFILACLFLIAVSFWKTPMECGIGFAIILSGLPVYFFGVWWKNKPKWILQAIFSVTVLCQKLMQVVPQET
uniprot
proteins
function
FUNCTION: Forms a heterodimer with SLC3A2 that functions as a sodium-independent transporter for large neutral amino acids (PubMed:9915839). Functions as an obligatory amino acid antiporter, mediating the exchange of amino acids and amino acid-related compounds across the plasma membrane (By similarity). Also mediates sodium-independent exchange of iodothyronines with neutral and aromatic L-alpha-amino acids (By similarity). Mediates exchange of L-tryptophan with the tryptophan metabolites L-kynurenine and 3-hydroxy-L-kynurenine (By similarity). Mediates cellular uptake of iodothyronines, including thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and 3,3'-diiodo-L-thyronine (3,3'-T2), and iodotyrosines including 3-iodo-L-tyrosine (MIT) and 3,5-diiodo-L-tyrosine (DIT) (By similarity). Participates in the transport of L-DOPA across the blood-brain barrier (PubMed:11011012). Involved in the uptake of methylmercury (MeHg) when administered as L-cysteine or D,L-homocysteine complexes, thereby contributing to metal ion homeostasis and toxicity (By similarity). Involved in the cellular activity of low-molecular-weight nitrosothiols through stereoselective transport of L-nitrosocysteine (L-CNSO) across the plasma membrane (By similarity). When associated with LAPTM4B, the heterodimer is recruited to lysosomes, where it promotes leucine uptake into these organelles and thereby contributes to mTORC1 activation (By similarity). {ECO:0000250|UniProtKB:Q01650, ECO:0000269|PubMed:11011012, ECO:0000269|PubMed:9915839}.
uniprot
proteins
mass_dalton
55872
uniprot
proteins
protein_family
Amino acid-polyamine-organocation (APC) superfamily
uniprot
proteins
protein_family
L-type amino acid transporter (LAT) (TC 2.A.3.8) family
uniprot
proteins
pubmed
10574970
uniprot
proteins
pubmed
11011012
uniprot
proteins
pubmed
11117468
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9915839
uniprot
proteins
sequence_length
512
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q01650}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q01650}. Cell membrane {ECO:0000269|PubMed:9915839}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q01650}. Lysosome membrane {ECO:0000250|UniProtKB:Q01650}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q01650}. Note=Located to the plasma membrane by SLC3A2/4F2hc (PubMed:9915839). Localized to the apical membrane of placental syncytiotrophoblastic cells. Recruited to lysosomes by LAPTM4B (By similarity). Expressed in both luminal and abluminal membranes of brain capillary endothelial cells (By similarity). {ECO:0000250|UniProtKB:Q01650, ECO:0000250|UniProtKB:Q63016, ECO:0000269|PubMed:9915839}.
uniprot
proteins
transmembrane_region
TRANSMEM 51..71; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q01650"; TRANSMEM 85..105; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q01650"; TRANSMEM 128..148; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q01650"; TRANSMEM 171..191; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q01650"; TRANSMEM 194..215; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q01650"; TRANSMEM 248..268; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q01650"; TRANSMEM 282..302; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q01650"; TRANSMEM 330..350; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q01650"; TRANSMEM 375..395; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q01650"; TRANSMEM 401..421; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q01650"; TRANSMEM 436..456; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q01650"; TRANSMEM 463..483; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q01650
uniprot
proteins