SP100
entrez
6672
canonical
uniprot
P23497
canonical
ensembl
ENSG00000067066
resolver
ensp
ENSP00000264052
resolver
ensp
ENSP00000343023
resolver
ensp
ENSP00000386404
resolver
ensp
ENSP00000386427
resolver
ensp
ENSP00000386998
resolver
ensp
ENSP00000399389
resolver
genesymbol
SP100
resolver
hgnc
HGNC:11206
resolver
uniprot
B4DDX5
resolver
uniprot
B8ZZD8
resolver
uniprot
E7EUA7
resolver
uniprot
E9PH61
resolver
uniprot
F8WFE2
resolver
uniprot
O75450
resolver
uniprot
Q13343
resolver
uniprot
Q8TE34
resolver
uniprot
Q96F70
resolver
uniprot
Q96T24
resolver
uniprot
Q96T95
resolver
uniprot
Q9NP33
resolver
uniprot
Q9UE32
resolver
uniprot_entry
SP100_HUMAN
resolver
uniprot_sec
B4DDX5
resolver
uniprot_sec
B8ZZD8
resolver
uniprot_sec
E7EUA7
resolver
uniprot_sec
E9PH61
resolver
uniprot_sec
F8WFE2
resolver
uniprot_sec
O75450
resolver
uniprot_sec
Q13343
resolver
uniprot_sec
Q8TE34
resolver
uniprot_sec
Q96F70
resolver
uniprot_sec
Q96T24
resolver
uniprot_sec
Q96T95
resolver
uniprot_sec
Q9NP33
resolver
uniprot_sec
Q9UE32
resolver
amino_acid_sequence
MAGGGGDLSTRRLNECISPVANEMNHLPAHSHDLQRMFTEDQGVDDRLLYDIVFKHFKRNKVEISNAIKKTFPFLEGLRDRDLITNKMFEDSQDSCRNLVPVQRVVYNVLSELEKTFNLPVLEALFSDVNMQEYPDLIHIYKGFENVIHDKLPLQESEEEEREERSGLQLSLEQGTGENSFRSLTWPPSGSPSHAGTTPPENGLSEHPCETEQINAKRKDTTSDKDDSLGSQQTNEQCAQKAEPTESCEQIAVQVNNGDAGREMPCPLPCDEESPEAELHNHGIQINSCSVRLVDIKKEKPFSNSKVECQAQARTHHNQASDIIVISSEDSEGSTDVDEPLEVFISAPRSEPVINNDNPLESNDEKEGQEATCSRPQIVPEPMDFRKLSTFRESFKKRVIGQDHDFSESSEEEAPAEASSGALRSKHGEKAPMTSRSTSTWRIPSRKRRFSSSDFSDLSNGEELQETCSSSLRRGSGSQPQEPENKKCSCVMCFPKGVPRSQEARTESSQASDMMDTMDVENNSTLEKHSGKRRKKRRHRSKVNGLQRGRKKDRPRKHLTLNNKVQKKRWQQRGRKANTRPLKRRRKRGPRIPKDENINFKQSELPVTCGEVKGTLYKERFKQGTSKKCIQSEDKKWFTPREFEIEGDRGASKNWKLSIRCGGYTLKVLMENKFLPEPPSTRKKRILESHNNTLVDPCEEHKKKNPDASVKFSEFLKKCSETWKTIFAKEKGKFEDMAKADKAHYEREMKTYIPPKGEKKKKFKDPNAPKRPPLAFFLFCSEYRPKIKGEHPGLSIDDVVKKLAGMWNNTAAADKQFYEKKAAKLKEKYKKDIAAYRAKGKPNSAKKRVVKAEKSKKKKEEEEDEEDEQEEENEEDDDK
uniprot
proteins
function
FUNCTION: Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. {ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:14647468, ECO:0000269|PubMed:15247905, ECO:0000269|PubMed:15592518, ECO:0000269|PubMed:15767676, ECO:0000269|PubMed:16177824, ECO:0000269|PubMed:17245429, ECO:0000269|PubMed:21274506, ECO:0000269|PubMed:21880768}.
uniprot
proteins
mass_dalton
100417
uniprot
proteins
mutagenesis
MUTAGEN 165; /note="R->A: Prevents CDC20-mediated degradation; when associated with Ala-168."; /evidence="ECO:0000269|PubMed:22086178"; MUTAGEN 168; /note="L->A: Prevents CDC20-mediated degradation; when associated with Ala-165."; /evidence="ECO:0000269|PubMed:22086178
uniprot
proteins
post_translational_modification
PTM: Sumoylated. Sumoylation depends on a functional nuclear localization signal but is not necessary for nuclear import or nuclear body targeting.; PTM: Sumoylated. Sumoylated with SUMO1. Sumoylation depends on a functional nuclear localization signal but is not necessary for nuclear import or nuclear body targeting. Sumoylation may stabilize the interaction with CBX5.; PTM: (Microbial infection) Immediate early protein IE1 of human cytomegalovirus (HHV-5) interferes with the sumoylation of SP100. {ECO:0000269|PubMed:10233977}.
uniprot
proteins
pubmed
10212234
uniprot
proteins
pubmed
10233977
uniprot
proteins
pubmed
10766566
uniprot
proteins
pubmed
11313457
uniprot
proteins
pubmed
11574059
uniprot
proteins
pubmed
11909962
uniprot
proteins
pubmed
12470659
uniprot
proteins
pubmed
14647468
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15247905
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592518
uniprot
proteins
pubmed
15767676
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
15882967
uniprot
proteins
pubmed
16177824
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17245429
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21118961
uniprot
proteins
pubmed
21274506
uniprot
proteins
pubmed
21880768
uniprot
proteins
pubmed
22086178
uniprot
proteins
pubmed
2258622
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23907639
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25593309
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
27211601
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
8695863
uniprot
proteins
pubmed
8810287
uniprot
proteins
pubmed
9412458
uniprot
proteins
pubmed
9636146
uniprot
proteins
pubmed
9973607
uniprot
proteins
sequence_length
879
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25593309}. Nucleus, PML body {ECO:0000269|PubMed:27211601}. Nucleus, nuclear body {ECO:0000269|PubMed:17245429}. Cytoplasm {ECO:0000269|PubMed:17245429}. Note=Differences in the subnuclear localization of the different isoforms seem to exist and may also be cell cycle- and interferon-dependent. Accumulates in the cytoplasm upon FAS activation. {ECO:0000269|PubMed:17245429}.; SUBCELLULAR LOCATION: [Isoform Sp100-C]: Nucleus {ECO:0000269|PubMed:11313457}. Note=Forms a reticulate or track-like nuclear pattern with denser concentrations at the nuclear lamina and surrounding the nucleoli, a pattern reminiscent of heterochromatin-rich regions according to PubMed:11313457.
uniprot
proteins