Rbm8a
entrez
60365
canonical
uniprot
Q9CWZ3
canonical
ensembl
ENSMUSG00000038374
resolver
ensp
ENSMUSP00000044548
resolver
ensp
ENSMUSP00000143190
resolver
genesymbol
Rbm8a
resolver
genesymbol_syn
Rbm8
resolver
uniprot
A0A023T672
resolver
uniprot
Q3UT38
resolver
uniprot
Q6GTD4
resolver
uniprot
Q9D6U5
resolver
uniprot_entry
RBM8A_MOUSE
resolver
uniprot_sec
A0A023T672
resolver
uniprot_sec
Q3UT38
resolver
uniprot_sec
Q6GTD4
resolver
uniprot_sec
Q9D6U5
resolver
amino_acid_sequence
MADVLDLHEAGGEDFAMDEDGDESIHKLKEKAKKRKGRGFGSEEGSRARMREDYDSVEQDGDEPGPQRSVEGWILFVTGVHEEATEEDIHDKFAEYGEIKNIHLNLDRRTGYLKGYTLVEYETYKEAQAAMEGLNGQDLMGQPISVDWCFVRGPPKGKRRGGRRRSRSPDRRRR
uniprot
proteins
function
FUNCTION: Required for pre-mRNA splicing as component of the spliceosome (By similarity). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its removal from cytoplasmic mRNAs requires translation initiation from EJC-bearing spliced mRNAs. Associates preferentially with mRNAs produced by splicing. Does not interact with pre-mRNAs, introns, or mRNAs produced from intronless cDNAs. Associates with both nuclear mRNAs and newly exported cytoplasmic mRNAs (By similarity). {ECO:0000250|UniProtKB:Q9Y5S9}.
uniprot
proteins
mass_dalton
19889
uniprot
proteins
protein_family
RBM8A family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24416299
uniprot
proteins
sequence_length
174
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y5S9}. Nucleus speckle {ECO:0000250|UniProtKB:Q9Y5S9}. Cytoplasm {ECO:0000250|UniProtKB:Q9Y5S9}. Note=Nucleocytoplasmic shuttling protein. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles. {ECO:0000250|UniProtKB:Q9Y5S9}.
uniprot
proteins