RBM24
entrez
221662
canonical
uniprot
Q9BX46
canonical
ensembl
ENSG00000112183
resolver
ensp
ENSP00000319551
resolver
ensp
ENSP00000368341
resolver
ensp
ENSP00000396898
resolver
ensp
ENSP00000797730
resolver
genesymbol
RBM24
resolver
genesymbol_syn
RNPC6
resolver
hgnc
HGNC:21539
resolver
uniprot
A8KAI7
resolver
uniprot
B7Z6B4
resolver
uniprot
B7Z6B7
resolver
uniprot
E9PAY4
resolver
uniprot
Q6QDA4
resolver
uniprot
Q8N9D3
resolver
uniprot
Q96NI3
resolver
uniprot_entry
A8KAI7_HUMAN
resolver
uniprot_entry
B7Z6B4_HUMAN
resolver
uniprot_entry
B7Z6B7_HUMAN
resolver
uniprot_entry
RBM24_HUMAN
resolver
uniprot_sec
E9PAY4
resolver
uniprot_sec
Q6QDA4
resolver
uniprot_sec
Q8N9D3
resolver
uniprot_sec
Q96NI3
resolver
amino_acid_sequence
MHTTQKDTTYTKIFVGGLPYHTTDASLRKYFEVFGEIEEAVVITDRQTGKSRGYGFVTMADRAAAERACKDPNPIIDGRKANVNLAYLGAKPRIMQPGFAFGVQQLHPALIQRPFGIPAHYVYPQAFVQPGVVIPHVQPTAAAASTTPYIDYTGAAYAQYSAAAAAAAAAAAYDQYPYAASPAAAGYVTAGGYGYAVQQPITAAAPGTAAAAAAAAAAAAAFGQYQPQQLQTDRMQ
uniprot
proteins
function
FUNCTION: Multifunctional RNA-binding protein involved in the regulation of pre-mRNA splicing, mRNA stability and mRNA translation important for cell fate decision and differentiation (PubMed:20977548, PubMed:24375645, PubMed:29104163, PubMed:29358667). Plays a major role in pre-mRNA alternative splicing regulation (PubMed:26990106, PubMed:29104163). Mediates preferentially muscle-specific exon inclusion in numerous mRNAs important for striated cardiac and skeletal muscle cell differentiation (PubMed:29104163). Binds to intronic splicing enhancer (ISE) composed of stretches of GU-rich motifs localized in flanking intron of exon that will be included by alternative splicing (By similarity). Involved in embryonic stem cell (ESC) transition to cardiac cell differentiation by promoting pre-mRNA alternative splicing events of several pluripotency and/or differentiation genes (PubMed:26990106). Plays a role in the regulation of mRNA stability (PubMed:20977548, PubMed:24356969, PubMed:24375645, PubMed:29104163). Binds to 3'-untranslated region (UTR) AU-rich elements in target transcripts, such as CDKN1A and MYOG, leading to maintain their stabilities (PubMed:20977548, PubMed:24356969). Involved in myogenic differentiation by regulating MYOG levels (PubMed:20977548). Binds to multiple regions in the mRNA 3'-UTR of TP63 isoform 2, hence inducing its destabilization (PubMed:24375645). Also promotes the destabilization of the CHRM2 mRNA via its binding to a region in the coding sequence (PubMed:29104163). Plays a role in the regulation of mRNA translation (PubMed:29358667). Mediates repression of p53/TP53 mRNA translation through its binding to U-rich element in the 3'-UTR, hence preventing EIF4E from binding to p53/TP53 mRNA and translation initiation (PubMed:29358667). Binds to a huge amount of mRNAs (PubMed:29104163). Required for embryonic heart development, sarcomer and M-band formation in striated muscles (By similarity). Together with RBM20, promotes the expression of short isoforms of PDLIM5/ENH in cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:D3Z4I3, ECO:0000250|UniProtKB:M0R7T6, ECO:0000269|PubMed:20977548, ECO:0000269|PubMed:24356969, ECO:0000269|PubMed:24375645, ECO:0000269|PubMed:26990106, ECO:0000269|PubMed:29104163, ECO:0000269|PubMed:29358667}.; FUNCTION: (Microbial infection) Promotes hepatitis C virus (HCV) replication over translation through the inhibition of viral protein expression. Decreases viral translation by linking viral 5'- and 3'-UTRs, blocking 80S ribosome assembly on the viral IRES and enhancing the interaction of the mature core protein and 5'-UTR. {ECO:0000269|PubMed:29380205}.
uniprot
proteins
mass_dalton
24776
uniprot
proteins
mutagenesis
MUTAGEN 181; /note="S->A: Decreases p53/TP53 expression."; /evidence="ECO:0000269|PubMed:29358667"; MUTAGEN 181; /note="S->D: Increases p53/TP53 expression."; /evidence="ECO:0000269|PubMed:29358667
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19658189
uniprot
proteins
pubmed
20977548
uniprot
proteins
pubmed
22345307
uniprot
proteins
pubmed
24356969
uniprot
proteins
pubmed
24375645
uniprot
proteins
pubmed
25313962
uniprot
proteins
pubmed
26990106
uniprot
proteins
pubmed
29104163
uniprot
proteins
pubmed
29358667
uniprot
proteins
pubmed
29380205
uniprot
proteins
sequence_length
236
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6GQD3}. Cytoplasm {ECO:0000250|UniProtKB:D3Z4I3}.
uniprot
proteins