Igfbp1
entrez
25685
canonical
uniprot
P21743
canonical
ensembl
ENSRNOG00000058780
resolver
ensembl
ENSRNOG00055030623
resolver
ensembl
ENSRNOG00060023137
resolver
ensembl
ENSRNOG00065019434
resolver
ensp
ENSRNOP00000069247
resolver
ensp
ENSRNOP00055043921
resolver
ensp
ENSRNOP00060033056
resolver
ensp
ENSRNOP00065026165
resolver
enst
ENSRNOT00000077177
resolver
enst
ENSRNOT00055053138
resolver
enst
ENSRNOT00060040051
resolver
enst
ENSRNOT00065032740
resolver
genesymbol
Igfbp1
resolver
genesymbol_syn
Igfbp-1
resolver
uniprot_entry
IBP1_RAT
resolver
amino_acid_sequence
MPEFLTVVSWPFLILLSFQVRVVAGAPQPWHCAPCTAERLELCPPVPASCPEISRPAGCGCCPTCALPLGAACGVATARCAQGLSCRALPGEPRPLHALTRGQGACVLEPAAPATSSLSGSQHEEAKAAVASEDELAESPEMTEEQLLDSFHLMAPSREDQPILWNAISTYSSMRAREITDLKKWKEPCQRELYKVLERLAAAQQKAGDEIYKFYLPNCNKNGFYHSKQCETSLDGEAGLCWCVYPWSGKKIPGSLETRGDPNCHQYFNVQN
uniprot
proteins
function
FUNCTION: Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including cell migration, proliferation, differentiation or apoptosis in a cell-type specific manner (PubMed:12111802). Also plays a positive role in cell migration by interacting with integrin ITGA5:ITGB1 through its RGD motif. Mechanistically, binding to integrins leads to activation of focal adhesion kinase/PTK2 and stimulation of the mitogen-activated protein kinase (MAPK) pathway (By similarity). Regulates cardiomyocyte apoptosis by suppressing HIF-1alpha/HIF1A ubiquitination and subsequent degradation (PubMed:34531382). {ECO:0000250|UniProtKB:P08833, ECO:0000269|PubMed:12111802, ECO:0000269|PubMed:34531382}.
uniprot
proteins
mass_dalton
29684
uniprot
proteins
pubmed
12111802
uniprot
proteins
pubmed
1283442
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1691820
uniprot
proteins
pubmed
1705004
uniprot
proteins
pubmed
2164920
uniprot
proteins
pubmed
34531382
uniprot
proteins
pubmed
7514892
uniprot
proteins
sequence_length
272
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P08833}.
uniprot
proteins