CXCL17
entrez
284340
canonical
uniprot
Q6UXB2
canonical
ensembl
ENSG00000189377
resolver
ensp
ENSP00000472467
resolver
enst
ENST00000601181
resolver
genesymbol
CXCL17
resolver
genesymbol_syn
VCC1
resolver
hgnc
HGNC:19232
resolver
uniprot
A8KAC0
resolver
uniprot_entry
CXL17_HUMAN
resolver
uniprot_sec
A8KAC0
resolver
amino_acid_sequence
MKVLISSLLLLLPLMLMSMVSSSLNPGVARGHRDRGQASRRWLQEGGQECECKDWFLRAPRRKFMTVSGLPKKQCPCDHFKGNVKKTRHQRHHRKPNKHSRACQQFLKQCQLRSFALPL
uniprot
proteins
function
FUNCTION: Chemokine that acts as a chemoattractant for monocytes, macrophages and dendritic cells, and which is involved in immune regulation and lymphocyte trafficking (PubMed:16455961, PubMed:23115081, PubMed:39293486, PubMed:40279398). Activates the C-X-C chemokine receptor GPR25 (PubMed:39293486, PubMed:40279398). Plays a key role in lymphocyte homing by activating the receptor GPR25 on lymphocytes, mediating lymphocyte recruitment into the respiratory, upper gastrointestinal, biliary and genito-urinary tracts (PubMed:39293486, PubMed:40279398). Plays a role in angiogenesis and possibly in the development of tumors (PubMed:16989774, PubMed:23115081). Acts as an anti-inflammatory in the stomach (PubMed:23115081). May play a role in the innate defense against infections (PubMed:17307946). {ECO:0000269|PubMed:16455961, ECO:0000269|PubMed:16989774, ECO:0000269|PubMed:17307946, ECO:0000269|PubMed:23115081, ECO:0000269|PubMed:39293486, ECO:0000269|PubMed:40279398}.; FUNCTION: [4-Cys CXCL17]: Seems to exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17. {ECO:0000269|PubMed:23115081}.
uniprot
proteins
mass_dalton
13819
uniprot
proteins
mutagenesis
MUTAGEN 50; /note="C->S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-52; S-75; S-77; S-103 and S-110."; /evidence="ECO:0000269|PubMed:16455961"; MUTAGEN 52; /note="C->S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-75; S-77; S-103 and S-110."; /evidence="ECO:0000269|PubMed:16455961"; MUTAGEN 75; /note="C->S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-77; S-103 and S-110."; /evidence="ECO:0000269|PubMed:16455961"; MUTAGEN 77; /note="C->S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-75; S-103 and S-110."; /evidence="ECO:0000269|PubMed:16455961"; MUTAGEN 103; /note="C->S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-75; S-77 and S-110."; /evidence="ECO:0000269|PubMed:16455961"; MUTAGEN 110; /note="C->S: Inhibits migration of nonactivated dendritic cells and monocytes; when associated with S-50; S-52; S-75; S-77 and S-103."; /evidence="ECO:0000269|PubMed:16455961
uniprot
proteins
post_translational_modification
PTM: Likely to undergo an endoproteolytic process to form a four-cysteine-containing mature peptide with a canonical CXC chemokine scaffold after secretion. {ECO:0000250|UniProtKB:D4A875}.
uniprot
proteins
protein_family
Intercrine alpha (chemokine CxC) family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16455961
uniprot
proteins
pubmed
16989774
uniprot
proteins
pubmed
17307946
uniprot
proteins
pubmed
23115081
uniprot
proteins
pubmed
25411203
uniprot
proteins
pubmed
25946035
uniprot
proteins
pubmed
29068046
uniprot
proteins
pubmed
29875152
uniprot
proteins
pubmed
39293486
uniprot
proteins
pubmed
40279398
uniprot
proteins
sequence_length
119
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23115081}.
uniprot
proteins