GGT5
entrez
2687
canonical
uniprot
P36269
canonical
ensembl
ENSG00000099998
resolver
ensp
ENSP00000263112
resolver
ensp
ENSP00000330080
resolver
ensp
ENSP00000381340
resolver
ensp
ENSP00000577717
resolver
ensp
ENSP00000577722
resolver
ensp
ENSP00000577726
resolver
ensp
ENSP00000577728
resolver
ensp
ENSP00000577729
resolver
ensp
ENSP00000577737
resolver
ensp
ENSP00000611087
resolver
ensp
ENSP00000664829
resolver
ensp
ENSP00000664833
resolver
ensp
ENSP00000664834
resolver
ensp
ENSP00000706792
resolver
ensp
ENSP00000706802
resolver
ensp
ENSP00000706810
resolver
ensp
ENSP00000772588
resolver
genesymbol
GGT5
resolver
genesymbol_syn
GGTLA1
resolver
hgnc
HGNC:4260
resolver
uniprot
B4DEL3
resolver
uniprot
Q53XM9
resolver
uniprot
Q6GMP0
resolver
uniprot
Q96FC1
resolver
uniprot
Q9UFM5
resolver
uniprot_entry
B4DEL3_HUMAN
resolver
uniprot_entry
GGT5_HUMAN
resolver
uniprot_sec
Q53XM9
resolver
uniprot_sec
Q6GMP0
resolver
uniprot_sec
Q96FC1
resolver
uniprot_sec
Q9UFM5
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by serine-borate. {ECO:0000269|PubMed:21447318}.
uniprot
proteins
amino_acid_sequence
MARGYGATVSLVLLGLGLALAVIVLAVVLSRHQAPCGPQAFAHAAVAADSKVCSDIGRAILQQQGSPVDATIAALVCTSVVNPQSMGLGGGVIFTIYNVTTGKVEVINARETVPASHAPSLLDQCAQALPLGTGAQWIGVPGELRGYAEAHRRHGRLPWAQLFQPTIALLRGGHVVAPVLSRFLHNSILRPSLQASTLRQLFFNGTEPLRPQDPLPWPALATTLETVATEGVEVFYTGRLGQMLVEDIAKEGSQLTLQDLAKFQPEVVDALEVPLGDYTLYSPPPPAGGAILSFILNVLRGFNFSTESMARPEGRVNVYHHLVETLKFAKGQRWRLGDPRSHPKLQNASRDLLGETLAQLIRQQIDGRGDHQLSHYSLAEAWGHGTGTSHVSVLGEDGSAVAATSTINTPFGAMVYSPRTGIILNNELLDLCERCPRGSGTTPSPVSGDRVGGAPGRCWPPVPGERSPSSMVPSILINKAQGSKLVIGGAGGELIISAVAQAIMSKLWLGFDLRAAIAAPILHVNSKGCVEYEPNFSQEVQRGLQDRGQNQTQRPFFLNVVQAVSQEGACVYAVSDLRKSGEAAGY
uniprot
proteins
ec_number
2.3.2.2
uniprot
proteins
ec_number
3.4.19.13
uniprot
proteins
ec_number
3.4.19.14
uniprot
proteins
function
FUNCTION: Cleaves the gamma-glutamyl bond of extracellular glutathione tripeptide (gamma-Glu-Cys-Gly) and certain glutathione conjugates (PubMed:1676842, PubMed:21447318). Hydrolyzes glutathione releasing L-Glu and Cys-Gly dipeptide which is further metabolized to maintain extracellular cysteine levels but also to provide cysteine necessary for intracellular glutathione synthesis (PubMed:1676842, PubMed:21447318). Among glutathione-S-conjugates metabolizes leukotriene C4 (LTC4) and S-geranylgeranyl-glutathione (GGG), but is inactive toward gamma-glutamyl leucine. Converts extracellular LTC4 to LTD4 during acute inflammatory response. Acts as a negative regulator of GGG bioactivity. GGT5 (via GGG catabolism) and ABCC1 (via extracellular transport) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to bone marrow parenchyma (By similarity). The transpeptidation reaction, i.e. the transfer of gamma-glutamyl moiety to an acceptor molecule to yield a new gamma-glutamyl compound requires high concentration of dipeptide acceptor and is considered nonphysiological (PubMed:21447318, PubMed:29667297). {ECO:0000250|UniProtKB:Q9Z2A9, ECO:0000269|PubMed:1676842, ECO:0000269|PubMed:21447318, ECO:0000303|PubMed:29667297}.
uniprot
proteins
mass_dalton
62261
uniprot
proteins
pathway_participation
PATHWAY: Sulfur metabolism; glutathione metabolism. {ECO:0000269|PubMed:21447318}.; PATHWAY: Lipid metabolism; leukotriene D4 biosynthesis. {ECO:0000269|PubMed:21447318}.
uniprot
proteins
post_translational_modification
PTM: Cleaved by autocatalysis into a large and a small subunit. {ECO:0000250|UniProtKB:P19440}.; PTM: Glycosylated. {ECO:0000250|UniProtKB:Q9Z2A9}.
uniprot
proteins
protein_family
Gamma-glutamyltransferase family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1676842
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
21447318
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29667297
uniprot
proteins
pubmed
30842656
uniprot
proteins
sequence_length
586
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9Z2A9}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9Z2A9}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000250|UniProtKB:Q9Z2A9
uniprot
proteins