PROC
entrez
5624
canonical
uniprot
P04070
canonical
ensembl
ENSG00000115718
resolver
ensp
ENSP00000234071
resolver
ensp
ENSP00000386679
resolver
ensp
ENSP00000553902
resolver
ensp
ENSP00000553903
resolver
ensp
ENSP00000553905
resolver
ensp
ENSP00000553913
resolver
ensp
ENSP00000553917
resolver
ensp
ENSP00000553920
resolver
ensp
ENSP00000553925
resolver
ensp
ENSP00000553930
resolver
ensp
ENSP00000553939
resolver
ensp
ENSP00000553940
resolver
ensp
ENSP00000553947
resolver
ensp
ENSP00000553952
resolver
ensp
ENSP00000553953
resolver
ensp
ENSP00000553954
resolver
ensp
ENSP00000643097
resolver
enst
ENST00000409048
resolver
enst
ENST00000883843
resolver
enst
ENST00000883844
resolver
enst
ENST00000883854
resolver
enst
ENST00000883858
resolver
enst
ENST00000883861
resolver
enst
ENST00000883880
resolver
enst
ENST00000883881
resolver
enst
ENST00000883888
resolver
enst
ENST00000883893
resolver
enst
ENST00000883894
resolver
enst
ENST00000883895
resolver
genesymbol
PROC
resolver
hgnc
HGNC:9451
resolver
uniprot
B4DPC8
resolver
uniprot
B4DPQ3
resolver
uniprot
B4DPQ7
resolver
uniprot
E7END6
resolver
uniprot
Q15189
resolver
uniprot
Q15190
resolver
uniprot
Q16001
resolver
uniprot
Q53S74
resolver
uniprot
Q9UC55
resolver
uniprot_entry
B4DPC8_HUMAN
resolver
uniprot_entry
B4DPQ3_HUMAN
resolver
uniprot_entry
E7END6_HUMAN
resolver
uniprot_entry
PROC_HUMAN
resolver
uniprot_sec
B4DPQ7
resolver
uniprot_sec
Q15189
resolver
uniprot_sec
Q15190
resolver
uniprot_sec
Q16001
resolver
uniprot_sec
Q53S74
resolver
uniprot_sec
Q9UC55
resolver
amino_acid_sequence
MWQLTSLLLFVATWGISGTPAPLDSVFSSSERAHQVLRIRKRANSFLEELRHSSLERECIEEICDFEEAKEIFQNVDDTLAFWSKHVDGDQCLVLPLEHPCASLCCGHGTCIDGIGSFSCDCRSGWEGRFCQREVSFLNCSLDNGGCTHYCLEEVGWRRCSCAPGYKLGDDLLQCHPAVKFPCGRPWKRMEKKRSHLKRDTEDQEDQVDPRLIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKLLVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATLSQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLNFIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFHGTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRDKEAPQKSWAP
uniprot
proteins
disease_involvement
DISEASE: Thrombophilia due to protein C deficiency, autosomal dominant (THPH3) [MIM:176860]: A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. Individuals with decreased amounts of protein C are classically referred to as having type I protein C deficiency and those with normal amounts of a functionally defective protein as having type II deficiency. {ECO:0000269|PubMed:1301959, ECO:0000269|PubMed:1347706, ECO:0000269|PubMed:1511989, ECO:0000269|PubMed:1868249, ECO:0000269|PubMed:2437584, ECO:0000269|PubMed:25618265, ECO:0000269|PubMed:25748729, ECO:0000269|PubMed:2602169, ECO:0000269|PubMed:7792728, ECO:0000269|PubMed:7865674, ECO:0000269|PubMed:8292730, ECO:0000269|PubMed:8398832, ECO:0000269|PubMed:8499568, ECO:0000269|PubMed:8560401, ECO:0000269|PubMed:8829639, ECO:0000269|PubMed:9798967}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Thrombophilia due to protein C deficiency, autosomal recessive (THPH4) [MIM:612304]: A hemostatic disorder characterized by impaired regulation of blood coagulation and a tendency to recurrent venous thrombosis. It results in a thrombotic condition that can manifest as a severe neonatal disorder or as a milder disorder with late-onset thrombophilia. The severe form leads to neonatal death through massive neonatal venous thrombosis. Often associated with ecchymotic skin lesions which can turn necrotic called purpura fulminans, this disorder is very rare. {ECO:0000269|PubMed:1511988, ECO:0000269|PubMed:1593215, ECO:0000269|PubMed:1611081, ECO:0000269|PubMed:25618265, ECO:0000269|PubMed:7841323, ECO:0000269|PubMed:7841324, ECO:0000269|PubMed:7878626}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.4.21.69
uniprot
proteins
function
FUNCTION: Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (PubMed:25618265, PubMed:39880037). Exerts a protective effect on the endothelial cell barrier function (PubMed:25651845). {ECO:0000269|PubMed:25618265, ECO:0000269|PubMed:25651845, ECO:0000269|PubMed:39880037}.
uniprot
proteins
mass_dalton
52071
uniprot
proteins
post_translational_modification
PTM: Carboxylated by vitamin K-dependent GGCX to form gamma-carboxyglutamate; these residues are essential for the binding of calcium. {ECO:0000269|PubMed:39880037}.; PTM: N- and O-glycosylated. Partial (70%) N-glycosylation of Asn-371 with an atypical N-X-C site produces a higher molecular weight form referred to as alpha. The lower molecular weight form, not N-glycosylated at Asn-371, is beta. O-glycosylated with core 1 or possibly core 8 glycans. {ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:1694179, ECO:0000269|PubMed:22171320, ECO:0000269|PubMed:2991887}.; PTM: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. {ECO:0000269|PubMed:1544894, ECO:0000269|PubMed:2991887}.; PTM: May be phosphorylated on a Ser or Thr in a region (AA 25-30) of the propeptide.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
1301959
uniprot
proteins
pubmed
1347706
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
1511988
uniprot
proteins
pubmed
1511989
uniprot
proteins
pubmed
1544894
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
1593215
uniprot
proteins
pubmed
1611081
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
1694179
uniprot
proteins
pubmed
1868249
uniprot
proteins
pubmed
22171320
uniprot
proteins
pubmed
22531345
uniprot
proteins
pubmed
22545135
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2437584
uniprot
proteins
pubmed
25618265
uniprot
proteins
pubmed
25651845
uniprot
proteins
pubmed
25748729
uniprot
proteins
pubmed
2602169
uniprot
proteins
pubmed
26091039
uniprot
proteins
pubmed
2991859
uniprot
proteins
pubmed
2991887
uniprot
proteins
pubmed
34502392
uniprot
proteins
pubmed
3511471
uniprot
proteins
pubmed
39880037
uniprot
proteins
pubmed
6589623
uniprot
proteins
pubmed
7605880
uniprot
proteins
pubmed
7792728
uniprot
proteins
pubmed
7841323
uniprot
proteins
pubmed
7841324
uniprot
proteins
pubmed
7865674
uniprot
proteins
pubmed
7878626
uniprot
proteins
pubmed
7919373
uniprot
proteins
pubmed
7974343
uniprot
proteins
pubmed
8003977
uniprot
proteins
pubmed
8292730
uniprot
proteins
pubmed
8324221
uniprot
proteins
pubmed
8398832
uniprot
proteins
pubmed
8446940
uniprot
proteins
pubmed
8477066
uniprot
proteins
pubmed
8499565
uniprot
proteins
pubmed
8499568
uniprot
proteins
pubmed
8560401
uniprot
proteins
pubmed
8829639
uniprot
proteins
pubmed
9003757
uniprot
proteins
pubmed
9798967
uniprot
proteins
sequence_length
461
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:25618265}. Golgi apparatus {ECO:0000269|PubMed:22531345, ECO:0000269|PubMed:25748729}. Endoplasmic reticulum {ECO:0000269|PubMed:22531345, ECO:0000269|PubMed:25748729}.
uniprot
proteins