Itpa
entrez
16434
canonical
uniprot
Q9D892
canonical
ensembl
ENSMUSG00000074797
resolver
ensp
ENSMUSP00000099482
resolver
enst
ENSMUST00000103193
resolver
genesymbol
Itpa
resolver
genesymbol_syn
ITPA
resolver
uniprot
Q60I30
resolver
uniprot
Q8R0Q8
resolver
uniprot_entry
ITPA_MOUSE
resolver
uniprot_entry
Q60I30_MOUSE
resolver
uniprot_sec
Q8R0Q8
resolver
amino_acid_sequence
MAASLVGKKIVFVTGNAKKLEEVIQILGDNFPCTLEAQKIDLPEYQGEPDEISIQKCREAARQVQGPVLVEDTCLCFNALGGLPGPYIKWFLQKLKPEGLHQLLAGFEDKSAYALCTFALSTGDPSQPVLLFRGQTSGQIVMPRGSRDFGWDPCFQPDGYEQTYAEMPKSEKNTISHRFRALHKLQEYFSVAAGAGDH
uniprot
proteins
ec_number
3.6.1.66
uniprot
proteins
function
FUNCTION: Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. {ECO:0000255|HAMAP-Rule:MF_03148, ECO:0000269|PubMed:17090528, ECO:0000269|PubMed:20081199, ECO:0000269|PubMed:20601097}.
uniprot
proteins
mass_dalton
21897
uniprot
proteins
protein_family
HAM1 NTPase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17090528
uniprot
proteins
pubmed
20081199
uniprot
proteins
pubmed
20601097
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
198
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03148}.
uniprot
proteins