C10orf90
entrez
118611
canonical
uniprot
Q96M02
canonical
ensembl
ENSG00000154493
resolver
ensp
ENSP00000284694
resolver
ensp
ENSP00000349318
resolver
ensp
ENSP00000474558
resolver
ensp
ENSP00000780800
resolver
enst
ENST00000488181
resolver
genesymbol
C10orf90
resolver
genesymbol_syn
FATS
resolver
hgnc
HGNC:26563
resolver
uniprot
B9EIQ9
resolver
uniprot
Q5JRP6
resolver
uniprot
Q5T023
resolver
uniprot
Q8NCV5
resolver
uniprot
Q8WU75
resolver
uniprot
S4R3N7
resolver
uniprot_entry
CJ090_HUMAN
resolver
uniprot_entry
S4R3N7_HUMAN
resolver
uniprot_sec
B9EIQ9
resolver
uniprot_sec
Q5JRP6
resolver
uniprot_sec
Q5T023
resolver
uniprot_sec
Q8NCV5
resolver
uniprot_sec
Q8WU75
resolver
amino_acid_sequence
MLKLSGEGLRDSYHSRRDQIALKNLQSDVTEAKSDFTKETLASQNTKMISSIVISQMIDENKSRENRASLPLPCAIAQSRAHHAKQSLANRSGVNIHRAFALLPGRLGIPAPSDERGPEAELPPKEERPCGGPRRGFASITITARRVGPPARALVWGTAGDSLCPKCRAEDTLFQAPPALANGAHPGRHQRSFACTEFSRNSSVVRLKVPEAHTGLCERRKYWVTHADDKETSFSPDTPLSGKSPLVFSSCVHLRVSQQCPDSIYYVDKSLSVPIEPPQIASPKMHRSVLSLNLNCSSHRLTADGVDGLVNREPISEALKQELLEGDQDLVGQRWNPGLQESHLKETPSLRRVHLGTGACPWSGSFPLENTELANVGANQVTVRKGEKDHTTHCHASDHANQLSIHIPGWSYRAVHTKVFSGSSKRQQGEVCMTVSAPPVEQKPTRHFLPIGDSSPSDDCLSRDLSEPTERRHQSFLKPRILFPGFLCPLQDVCASLQEDNGVQIESKFPKGDYTCCDLVVKIKECKKSEDPTTPEPSPAAPSPAPRDGAGSPGLSEDCSESQQTPARSLTLQEALEVRKPQFISRSQERLKKLEHMVQQRKAQRKEDLRQKQSLLPIRTSKKQFTIPHPLSDNLFKPKERCISEKEMHMRSKRIYDNLPEVKKKKEEQRKRVILQSNRLRAEVFKKQLLDQLLQRNAV
uniprot
proteins
ec_number
2.3.2.-
uniprot
proteins
function
FUNCTION: Tumor suppressor that is required to sustain G2/M checkpoint after DNA damage. Acts as a p53/TP53 activator by inhibiting MDM2 binding to p53/TP53 and stimulating non-proteolytic polyubiquitination of p53/TP53. Exhibits ubiquitin ligase (E3) activity and assemble ubiquitin polymers through 'Lys-11'- (K11-), 'Lys-29'- (K29-) and 'Lys-63'- (K63)-linkages, independently of the ubiquitin-conjugating enzyme (E2). Promotes p53/TP53-dependent transcription of CDKN1A/p21, leading to robust checkpoint response. Mediates CDKN1A/p21 protein stability in a ubiquitin-independent manner. Interacts with HDAC1 and prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21 (By similarity). May have a role in the assembly of primary cilia (Probable). {ECO:0000250|UniProtKB:D2J0Y4, ECO:0000305|PubMed:20844083}.
uniprot
proteins
mass_dalton
77910
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20844083
uniprot
proteins
sequence_length
699
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20844083}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20844083}. Note=Localizes to the actin cytoskeleton in a proportion of cells. Colocalizes with centriolar acetylated tubulin. {ECO:0000269|PubMed:20844083}.
uniprot
proteins