Dusp1
entrez
19252
canonical
uniprot
P28563
canonical
ensembl
ENSMUSG00000024190
resolver
ensp
ENSMUSP00000025025
resolver
enst
ENSMUST00000025025
resolver
genesymbol
Dusp1
resolver
genesymbol_syn
3ch134
resolver
genesymbol_syn
Mkp1
resolver
genesymbol_syn
Ptpn10
resolver
genesymbol_syn
Ptpn16
resolver
uniprot
Q3U8K3
resolver
uniprot_entry
DUS1_MOUSE
resolver
uniprot_entry
Q3U8K3_MOUSE
resolver
amino_acid_sequence
MVMEVGILDAGGLRALLREGAAQCLLLDCRSFFAFNAGHIAGSVNVRFSTIVRRRAKGAMGLEHIVPNAELRGRLLAGAYHAVVLLDERSASLDGAKRDGTLALAAGALCREARSTQVFFLQGGYEAFSASCPELCSKQSTPTGLSLPLSTSVPDSAESGCSSCSTPLYDQGGPVEILSFLYLGSAYHASRKDMLDALGITALINVSANCPNHFEGHYQYKSIPVEDNHKADISSWFNEAIDFIDSIKDAGGRVFVHCQAGISRSATICLAYLMRTNRVKLDEAFEFVKQRRSIISPNFSFMGQLLQFESQVLAPHCSAEAGSPAMAVLDRGTSTTTVFNFPVSIPVHPTNSALNYLKSPITTSPSC
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle. {ECO:0000269|PubMed:8221888}.
uniprot
proteins
mass_dalton
39370
uniprot
proteins
mutagenesis
MUTAGEN 257..264; /note="Missing: Loss of phosphatase activity."; /evidence="ECO:0000269|PubMed:8355678"; MUTAGEN 258; /note="C->S: Loss of phosphatase activity."; /evidence="ECO:0000269|PubMed:8221888
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-359 and Ser-364 by MAPK1/ERK2 and MAPK3/ERK1 reduces its rate of degradation. {ECO:0000269|PubMed:10617468}.; PTM: 'Lys-48'-linked polyubiquitinated by NEURL3, leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q91790}.
uniprot
proteins
protein_family
Non-receptor class dual specificity subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
10617468
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1741163
uniprot
proteins
pubmed
8221888
uniprot
proteins
pubmed
8355678
uniprot
proteins
sequence_length
367
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q91790}.
uniprot
proteins