Rab26
entrez
171111
canonical
uniprot
P51156
canonical
ensembl
ENSRNOG00000042086
resolver
ensp
ENSRNOP00000004249
resolver
ensp
ENSRNOP00000083203
resolver
ensp
ENSRNOP00000104150
resolver
enst
ENSRNOT00000004249
resolver
enst
ENSRNOT00000097378
resolver
genesymbol
Rab26
resolver
uniprot
A0A8I5ZZI4
resolver
uniprot
A0A8L2Q1F9
resolver
uniprot
Q6P6W7
resolver
uniprot_entry
A0A8I5ZZI4_RAT
resolver
uniprot_entry
A0A8L2Q1F9_RAT
resolver
uniprot_entry
RAB26_RAT
resolver
uniprot_sec
Q6P6W7
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MSRKKTPKSKGGSVPAASTLPAAANGPRLAHPRTARPGPEAPPNGPPQSGRPSLGGTGDFYDVAFKVMLVGDSGVGKTCLLVRFKDGAFLAGTFISTVGIDFRNKVLDVDGMKVKLQIWDTAGQERFRSVTHAYYRDAHALLLLYDITNKDSFDNIQAWLTEIQEYAQQDVVLMLLGNKVDSTQERVVKREDGEKLAKEYGLPFMETSAKSGLNVDLAFTAIAKELKQRSTKAPSEPRFRLHDYVKREGRGVSCCRL
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB26 mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach (By similarity). Plays a role in the secretion of amylase from acinar granules in the parotid gland (PubMed:10857477, PubMed:16076461). {ECO:0000250|UniProtKB:P61006, ECO:0000250|UniProtKB:Q9ULW5, ECO:0000269|PubMed:10857477, ECO:0000269|PubMed:16076461}.
uniprot
proteins
mass_dalton
28203
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10857477
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16076461
uniprot
proteins
pubmed
7864900
uniprot
proteins
sequence_length
257
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:10857477, ECO:0000269|PubMed:16076461}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9ULW5}; Lipid-anchor {ECO:0000250|UniProtKB:Q9ULW5}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9ULW5}. Note=Inhibition of S-geranylgeranyl cysteine formation abolishes membrane location (By similarity). Localized immediately around secretory granules in the acinar cells of the parotid gland (PubMed:10857477). Not localized in plasma membranes (PubMed:10857477). {ECO:0000250, ECO:0000269|PubMed:10857477}.
uniprot
proteins