ARPP19
entrez
10776
canonical
uniprot
P56211
canonical
ensembl
ENSG00000128989
resolver
ensp
ENSP00000249822
resolver
ensp
ENSP00000454234
resolver
ensp
ENSP00000454341
resolver
ensp
ENSP00000454612
resolver
ensp
ENSP00000455151
resolver
ensp
ENSP00000455625
resolver
ensp
ENSP00000455986
resolver
ensp
ENSP00000717198
resolver
enst
ENST00000561971
resolver
enst
ENST00000564163
resolver
genesymbol
ARPP19
resolver
hgnc
HGNC:16967
resolver
uniprot
B2R497
resolver
uniprot
H3BMD8
resolver
uniprot
Q6IAM2
resolver
uniprot
Q86TA6
resolver
uniprot
Q9UD70
resolver
uniprot_entry
ARP19_HUMAN
resolver
uniprot_entry
H3BMD8_HUMAN
resolver
uniprot_sec
B2R497
resolver
uniprot_sec
Q6IAM2
resolver
uniprot_sec
Q86TA6
resolver
uniprot_sec
Q9UD70
resolver
amino_acid_sequence
MSAEVPEAASAEEQKEMEDKVTSPEKAEEAKLKARYPHLGQKPGGSDFLRKRLQKGQKYFDSGDYNMAKAKMKNKQLPTAAPDKTEVTGDHIPTPQDLPQRKPSLVASKLAG
uniprot
proteins
function
FUNCTION: Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) (PubMed:28167675, PubMed:38123684). Inhibition of PP2A is enhanced when ARPP19 is phosphorylated (PubMed:28167675, PubMed:38123684). When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (PubMed:21164014). May indirectly enhance GAP-43 expression (By similarity). {ECO:0000250|UniProtKB:Q712U5, ECO:0000269|PubMed:21164014, ECO:0000269|PubMed:28167675, ECO:0000269|PubMed:38123684}.
uniprot
proteins
mass_dalton
12323
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-62 by MASTL/GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A (By similarity). Phosphorylated at Ser-104 by PKA (PubMed:28613156). Phosphorylated at Ser-62 by MAST3 (PubMed:28167675, PubMed:28613156). Phosphorylation by PKA and MAST3 is mutually antagonistic, with each kinase inhibiting phosphorylation by the other (PubMed:28613156). {ECO:0000250|UniProtKB:Q6DEB4, ECO:0000269|PubMed:28167675, ECO:0000269|PubMed:28613156}.
uniprot
proteins
protein_family
Endosulfine family
uniprot
proteins
pubmed
10754390
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
17893145
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20218812
uniprot
proteins
pubmed
21164014
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28167675
uniprot
proteins
pubmed
28613156
uniprot
proteins
pubmed
38123684
uniprot
proteins
pubmed
8120638
uniprot
proteins
pubmed
9653196
uniprot
proteins
sequence_length
112
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins