CLIC2
entrez
1193
canonical
uniprot
O15247
canonical
ensembl
ENSG00000155962
resolver
ensp
ENSP00000358460
resolver
enst
ENST00000369449
resolver
genesymbol
CLIC2
resolver
hgnc
HGNC:2063
resolver
uniprot
A8K9S0
resolver
uniprot
O15174
resolver
uniprot
Q5JT80
resolver
uniprot
Q8TCE3
resolver
uniprot_entry
CLIC2_HUMAN
resolver
uniprot_sec
A8K9S0
resolver
uniprot_sec
O15174
resolver
uniprot_sec
Q5JT80
resolver
uniprot_sec
Q8TCE3
resolver
activity_regulation
ACTIVITY REGULATION: The channel conductance is regulated by pH. {ECO:0000269|PubMed:17945253}.
uniprot
proteins
amino_acid_sequence
MSGLRPGTQVDPEIELFVKAGSDGESIGNCPFCQRLFMILWLKGVKFNVTTVDMTRKPEELKDLAPGTNPPFLVYNKELKTDFIKIEEFLEQTLAPPRYPHLSPKYKESFDVGCNLFAKFSAYIKNTQKEANKNFEKSLLKEFKRLDDYLNTPLLDEIDPDSAEEPPVSRRLFLDGDQLTLADCSLLPKLNIIKVAAKKYRDFDIPAEFSGVWRYLHNAYAREEFTHTCPEDKEIENTYANVAKQKS
uniprot
proteins
ec_number
1.11.1.-
uniprot
proteins
ec_number
1.8.-.-
uniprot
proteins
function
FUNCTION: In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Displays weak glutathione peroxidase activity (Probable) (PubMed:25581026). Can insert into membranes and form chloride ion channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Modulates the activity of RYR2 and inhibits calcium influx. {ECO:0000269|PubMed:15147738, ECO:0000269|PubMed:15916532, ECO:0000269|PubMed:17945253, ECO:0000269|PubMed:25581026, ECO:0000305|PubMed:15147738}.
uniprot
proteins
mass_dalton
28356
uniprot
proteins
protein_family
Chloride channel CLIC family
uniprot
proteins
pubmed
12681486
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15147738
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
15916532
uniprot
proteins
pubmed
17945253
uniprot
proteins
pubmed
18186468
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814392
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25581026
uniprot
proteins
pubmed
9339381
uniprot
proteins
sequence_length
247
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15916532}. Membrane {ECO:0000305|PubMed:15916532}; Single-pass membrane protein {ECO:0000305|PubMed:15916532}. Note=Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain.
uniprot
proteins
transmembrane_region
TRANSMEM 32..52; /note="Helical; Note=After insertion into the membrane"; /evidence="ECO:0000255
uniprot
proteins