Marcks
entrez
17118
canonical
uniprot
P26645
canonical
ensembl
ENSMUSG00000069662
resolver
ensp
ENSMUSP00000090245
resolver
enst
ENSMUST00000092584
resolver
genesymbol
Marcks
resolver
genesymbol_syn
Macs
resolver
uniprot_entry
MARCS_MOUSE
resolver
amino_acid_sequence
MGAQFSKTAAKGEATAERPGEAAVASSPSKANGQENGHVKVNGDASPAAAEPGAKEELQANGSAPAADKEEPASGSAATPAAAEKDEAAAATEPGAGAADKEAAEAEPAEPSSPAAEAEGASASSTSSPKAEDGAAPSPSSETPKKKKKRFSFKKSFKLSGFSFKKSKKESGEGAEAEGATAEGAKDEAAAAAGGEGAAAPGEQAGGAGAEGAAGGEPREAEAAEPEQPEQPEQPAAEEPQAEEQSEAAGEKAEEPAPGATAGDASSAAGPEQEAPAATDEAAASAAPAASPEPQPECSPEAPPAPTAE
uniprot
proteins
function
FUNCTION: Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes. Thus, exerts an influence on a plethora of physiological processes, such as embryonic development, tissue regeneration, neuronal plasticity, and inflammation (PubMed:30185885, PubMed:30655546, PubMed:8700893). Sequesters phosphatidylinositol 4,5-bisphosphate (PIP2) at lipid rafts in the plasma membrane of quiescent cells, an action reversed by protein kinase C, ultimately inhibiting exocytosis (By similarity). During inflammation, promotes the migration of inflammatory cells and the secretion of cytokines such as tumor necrosis factor (TNF), particularly in macrophages (PubMed:20205598). Plays an essential role in bacteria-induced intracellular reactive oxygen species (ROS) formation in the monocytic cell type. Participates in the regulation of neurite initiation and outgrowth by interacting with components of cellular machinery including CDC42 that regulates cell shape and process extension through modulation of the cytoskeleton (PubMed:30185885). Also plays a role in axon development by mediating docking and fusion of RAB10-positive vesicles with the plasma membrane (By similarity). {ECO:0000250|UniProtKB:P29966, ECO:0000250|UniProtKB:P30009, ECO:0000269|PubMed:20205598, ECO:0000269|PubMed:30185885, ECO:0000269|PubMed:30655546, ECO:0000269|PubMed:8700893}.
uniprot
proteins
mass_dalton
29661
uniprot
proteins
mutagenesis
MUTAGEN 113; /note="S->A: Poorly phosphorylated."; /evidence="ECO:0000269|PubMed:8849678"; MUTAGEN 165; /note="K->A: Strong loss of acetylation."; /evidence="ECO:0000269|PubMed:30655546
uniprot
proteins
post_translational_modification
PTM: Acetylated at Lys-165 by KAT5; acetylation is required for its subsequent phosphorylation. Deacetylated by SIRT2. {ECO:0000269|PubMed:30655546}.; PTM: Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity. PKC-mediated phosphorylation increases 4 to 5-fold upon TNF or LPS induction. {ECO:0000250|UniProtKB:P29966}.; PTM: Myristoylated. A proper myristoylation is essential for the proper distribution to the plasma membrane. {ECO:0000250|UniProtKB:P29966}.; PTM: Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity. {ECO:0000269|PubMed:7588787, ECO:0000269|PubMed:8849678}.
uniprot
proteins
protein_family
MARCKS family
uniprot
proteins
pubmed
12577052
uniprot
proteins
pubmed
1396720
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
1868832
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
2006186
uniprot
proteins
pubmed
20205598
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2384168
uniprot
proteins
pubmed
30185885
uniprot
proteins
pubmed
30655546
uniprot
proteins
pubmed
7588787
uniprot
proteins
pubmed
8700893
uniprot
proteins
pubmed
8849678
uniprot
proteins
sequence_length
309
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:30185885}; Lipid-anchor {ECO:0000269|PubMed:30185885}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P29966}. Cytoplasm {ECO:0000269|PubMed:30185885, ECO:0000269|PubMed:30655546}. Note=PKC-dependent phosphorylation displaces MARCKS from the cell membrane and subsequent dephosphorylation is accompanied by its reassociation with the membrane. {ECO:0000250|UniProtKB:P29966}.
uniprot
proteins