Nlrc3
entrez
268857
canonical
uniprot
Q5DU56
canonical
ensembl
ENSMUSG00000049871
resolver
ensp
ENSMUSP00000137325
resolver
ensp
ENSMUSP00000137628
resolver
enst
ENSMUST00000177551
resolver
genesymbol
Nlrc3
resolver
uniprot
A1L3P6
resolver
uniprot
J3QQ49
resolver
uniprot
Q3TAB7
resolver
uniprot
Q8BJF4
resolver
uniprot
Q8BV65
resolver
uniprot_entry
J3QQ49_MOUSE
resolver
uniprot_entry
NLRC3_MOUSE
resolver
uniprot_sec
A1L3P6
resolver
uniprot_sec
Q3TAB7
resolver
uniprot_sec
Q8BJF4
resolver
uniprot_sec
Q8BV65
resolver
amino_acid_sequence
MRRRYSHDPPGSFRETKVFGFRGEYGCKALVDLLAGKGSQLLQVRDKMPDSPLGSQSNESRIPKHSEALLSRVGNDPELGSPSHRLASLMLVEGLTDLQLKEHDFTQVEATRGVWHPARVITLDRLFLPLSRVSIPPRVSLTIGVAGVGKTTLVRHFVHCWARGQVGKGFSRVLPLTFRDLNTYEKLSADRLIQSIFSSIGEASLVATAPDRVLLVLDGLDECKTPLEFSNTMACSDPKKEIQVDHLITNIIRGNLFPEISVWITSRPSAAGQIPGGLVDRMTEIRGLTEEEIKVCLEQMFPEEQNLLGQVLSQVQANRALYLMCTVPAFCRLTGLALGHLYRTRLAVQDIELPLPQTLCELYSWYFRMALGGEGQDKEKVSPRIKQVTQGARKMVGTLGRLAFHGLVKKKYVFYEQDMKAFGVDLALLQNTLCSCLLQREETLASSVAYCFIHLSLQEFVAATYYYSASKRAIFDLFTESGMSWPRLGFLAHFRCAAQRATQAKDGRLDVFLRFLSGLLSPRVNTLLAGSLLSQGEHQSYRDQVAEVLQGFLHPDAAVCARAINVLYCLSELRHTELACSVEEAMRSGTLAGMTSPSHRTALAYLLQMSDICSPEADFSLCLSQHVLQSLLPQLLYCQSLRLDNNQFQDPVMELLGSVLSGKDCRIRKISLAENQIGNKGAKALARSLLVNRSLITLDLRSNSIGPPGAKALADALKINRTLTSLSLQSNVIKDDGVMCVAEALVSNQTISMLQLQKNLIGLIGAQQMADALKQNRSLKALMFSSNTIGDRGAIALAEALKVNQILENLDLQSNSISDMGVTVLMRALCSNQTLSSLNLRENSISPEGAQALTQALCRNNTLKHLDLTANLLHDRGAQAIAVAVGENHSLTHLHLQWNFIQAGAARALGQALQLNRTLTTLDLQENAIGDEGASSVAGALKVNTTLIALYLQVASIGSQGAQALGEALTVNRTLEILDLRGNDVGAAGAKALANALKLNSSLRRLNLQENSLGMDGAIFVASALSENHGLHHINLQGNPIGESAARMISEAIKTNAPTCTVEI
uniprot
proteins
function
FUNCTION: Negative regulator of the innate immune response. Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA:dT), but not poly(I:C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1) (PubMed:22863753, PubMed:24560620). May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating 'Lys-63'-linked ubiquitination and leaving unchanged the degradative 'Lys-48'-linked ubiquitination (PubMed:22863753). Inhibits the PI3K-AKT-mTOR pathway possibly by directly interacting with the posphatidylinositol 3-kinase regulatory subunit p85 (PIK3R1/PIK3R2) and disrupting the association between PIK3R1/PIK3R2 and the catalytic subunit p110 (PIK3CA/PIK3CB/PIK3CD) and reducing PIK3R1/PIK3R2 activation. Via its regulation of the PI3K-AKT-mTOR pathway, controls cell proliferation, predominantly in intestinal epithelial cells (PubMed:27951586). May also affect NOD1- or NOD2-mediated NF-kappa-B activation (By similarity). Might also affect the inflammatory response by preventing NLRP3 inflammasome formation, CASP1 cleavage and IL1B maturation (By similarity). {ECO:0000250|UniProtKB:Q7RTR2, ECO:0000269|PubMed:22863753, ECO:0000269|PubMed:24560620, ECO:0000269|PubMed:27951586}.
uniprot
proteins
mass_dalton
115993
uniprot
proteins
protein_family
NLRP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
22863753
uniprot
proteins
pubmed
24560620
uniprot
proteins
pubmed
27951586
uniprot
proteins
sequence_length
1064
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q7RTR2}.
uniprot
proteins