Lrrc8d
entrez
231549
canonical
uniprot
Q8BGR2
canonical
ensembl
ENSMUSG00000046079
resolver
ensp
ENSMUSP00000057293
resolver
ensp
ENSMUSP00000113603
resolver
ensp
ENSMUSP00000208131
resolver
ensp
ENSMUSP00000208132
resolver
ensp
ENSMUSP00000208133
resolver
ensp
ENSMUSP00000208142
resolver
enst
ENSMUST00000060531
resolver
enst
ENSMUST00000120847
resolver
genesymbol
Lrrc8d
resolver
genesymbol_syn
Lrrc5
resolver
uniprot
Q3UVA9
resolver
uniprot
Q8CI13
resolver
uniprot_entry
LRC8D_MOUSE
resolver
uniprot_sec
Q3UVA9
resolver
uniprot_sec
Q8CI13
resolver
amino_acid_sequence
MFTLAEVASLNDIQPTYRILKPWWDVFMDYLAVVMLMVAIFAGTMQLTKDQVVCLPVLPSPANSKAHTPPGNADITTEVPRMETATHQDQNGQTTTNDVAFGTSAVTPDIPLQATHPHAESTLPNQEAKKEKRDPTGRKTNLDFQQYVFINQMCYHLALPWYSKYFPYLALIHTIILMVSSNFWFKYPKTCSKVEHFVSILGKCFESPWTTKALSETACEDSEENKQRITGAQTLPKHVSTSSDEGSPSASTPMINKTGFKFSAEKPVIEVPSMTILDKKDGEQAKALFEKVRKFRAHVEDSDLIYKLYVVQTLIKTAKFIFILCYTANFVNAISFEHVCKPKVEHLTGYEVFECTHNMAYMLKKLLISYISIICVYGFICLYTLFWLFRIPLKEYSFEKVREESSFSDIPDVKNDFAFLLHMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHVSRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESLRELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVAIPPSITHVKNLESLYFSNNKLESLPTAVFSLQKLRCLDVSYNNISTIPIEIGLLQNLQHLHITGNKVDILPKQLFKCVKLRTLNLGQNCIASLPEKISQLTQLTQLELKGNCLDRLPAQLGQCRMLKKSGLVVEDQLFDTLPLEVKEALNQDVNVPFANGI
uniprot
proteins
function
FUNCTION: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:29773801, PubMed:36522427). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Plays a redundant role in the efflux of amino acids, such as aspartate, in response to osmotic stress family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (By similarity). Also acts as a regulator of glucose-sensing in pancreatic beta cells: VRAC currents, generated in response to hypotonicity- or glucose-induced beta cell swelling, depolarize cells, thereby causing electrical excitation, leading to increase glucose sensitivity and insulin secretion (PubMed:29773801). VRAC channels containing LRRC8D inhibit transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (PubMed:36522427). {ECO:0000250|UniProtKB:Q7L1W4, ECO:0000269|PubMed:29773801, ECO:0000269|PubMed:36522427}.
uniprot
proteins
mass_dalton
98113
uniprot
proteins
protein_family
LRRC8 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24782309
uniprot
proteins
pubmed
29773801
uniprot
proteins
pubmed
36522427
uniprot
proteins
sequence_length
859
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29773801}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7L1W4}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q7L1W4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7L1W4}. Note=In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum (PubMed:29773801). Requires LRRC8A for expression at the cell membrane (By similarity). {ECO:0000250|UniProtKB:Q7L1W4, ECO:0000269|PubMed:29773801}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..48; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q7L1W4"; TRANSMEM 165..183; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q7L1W4"; TRANSMEM 310..331; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q7L1W4"; TRANSMEM 362..387; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q7L1W4
uniprot
proteins