Chaf1a
entrez
27221
canonical
uniprot
Q9QWF0
canonical
ensembl
ENSMUSG00000002835
resolver
ensp
ENSMUSP00000002914
resolver
enst
ENSMUST00000002914
resolver
genesymbol
Chaf1a
resolver
genesymbol_syn
Caip150
resolver
uniprot
Q3TU22
resolver
uniprot
Q544M2
resolver
uniprot_entry
CAF1A_MOUSE
resolver
uniprot_sec
Q3TU22
resolver
uniprot_sec
Q544M2
resolver
amino_acid_sequence
MLEEPEAATRTAAAVDCKDRPGFPVKRLIQARLPFKRLNLVPKEKVEEDTSPKAAVESKVPDLQLSLGTFESQCHTGSHVGLSTKLVGGQGPIDSFLRATIKPVPSVVIIDLTENCSDIPDSPEGHSELSPDTAGVVTTVEGAAKQQEHSAAELCLLETPSDITCHMEEEPGSPGDPKRTGDCQAGSLQSCPELTPGSRTCPTKELSSWSKAGDLLFIEKVPVVVLEDILATKPSIASLPMMSLDRSVTSESEILESCPEDDSILSHSSTNSSSPTSSPEGPSTPPEHRGGRSSPSTPACRVAKNFVKGSTEKGRSKLHRDREQQREEKEKLREEIRRAKEEARKKKEEEKELKEKERREKREKDEKEKAEKQRLKEEKRKERQEALEAKLEEKRKKEEEKRLREEEKRLREEEKRIKAEKAEITRFFQKPKTPQAPKTLAGSCGKFAPFEIKEHMVLAPRCRAALDQDLCDQLDQLLQQQSVASTFLSDLKSRLPLRSGPTRVCGHDTDIMNRDVVIVESSKVDGVSERKKFGRMKLLQFSENHRPAYWGTWNKKTAIIRPRNPWAQDKDLLDYEVDSDDEWEEEEPGESLSHSEGDEDDDVGEDEDEDDGFFVPHGYLSEDEGVTEECADPENHKVHQKLKAKEWDELLAKGKRFRVLQPVHVGCVWASEAANCTSSDLKLLQQFTACLLDVASPDEPEPGASRREKRDQHILAQLLPLLHGNVNGSKVIIHEFQEQCRRGLLTLPSPTPHLQMPNLEDAVAVPSKARLKRLISENSAYEKRPNFRMCWYVHPEVLKSFGQECLPVPCQWTYITTMPSAPREDSGSASTEGPGQSTPMLLKRKPAATMCITQFMKKRRYDGQVGSGDMDGFQADTEEDEEDDTDCMIIDVPDVGSDVSEAPIPAPTLCK
uniprot
proteins
function
FUNCTION: Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci. {ECO:0000250|UniProtKB:Q5R1T0}.
uniprot
proteins
mass_dalton
101936
uniprot
proteins
mutagenesis
MUTAGEN 224; /note="V->N,E: Prevents binding to CBX1 and CBX5."; /evidence="ECO:0000269|PubMed:10549285"; MUTAGEN 224; /note="V->S,D: Prevents binding to CBX1 and CBX5."; /evidence="ECO:0000269|PubMed:10549285
uniprot
proteins
protein_family
CHAF1A family
uniprot
proteins
pubmed
10549285
uniprot
proteins
pubmed
12697822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
911
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13111}. Note=DNA replication foci. {ECO:0000250|UniProtKB:Q13111}.
uniprot
proteins