CAPZB
entrez
832
canonical
uniprot
P47756
canonical
ensembl
ENSG00000077549
resolver
ensp
ENSP00000264202
resolver
ensp
ENSP00000264203
resolver
ensp
ENSP00000364284
resolver
ensp
ENSP00000401010
resolver
ensp
ENSP00000666432
resolver
enst
ENST00000264203
resolver
enst
ENST00000433834
resolver
genesymbol
CAPZB
resolver
hgnc
HGNC:1491
resolver
uniprot
A0A384MR50
resolver
uniprot
B1AK85
resolver
uniprot
B1AK88
resolver
uniprot
B3KWH5
resolver
uniprot
B4DWA6
resolver
uniprot
Q32Q68
resolver
uniprot
Q5U0L4
resolver
uniprot
Q7L4N0
resolver
uniprot
Q8TB49
resolver
uniprot
Q9NUC4
resolver
uniprot_entry
A0A384MR50_HUMAN
resolver
uniprot_entry
B1AK85_HUMAN
resolver
uniprot_entry
B1AK88_HUMAN
resolver
uniprot_entry
B3KWH5_HUMAN
resolver
uniprot_entry
B4DWA6_HUMAN
resolver
uniprot_entry
CAPZB_HUMAN
resolver
uniprot_entry
Q7L4N0_HUMAN
resolver
uniprot_sec
Q32Q68
resolver
uniprot_sec
Q5U0L4
resolver
uniprot_sec
Q8TB49
resolver
uniprot_sec
Q9NUC4
resolver
amino_acid_sequence
MSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKTKDIVNGLRSVQTFADKSKQEALKNDLVEALKRKQQC
uniprot
proteins
function
FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A9XFX6, ECO:0000269|PubMed:21834987}.
uniprot
proteins
mass_dalton
30629
uniprot
proteins
protein_family
F-actin-capping protein beta subunit family
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15850461
uniprot
proteins
pubmed
16678097
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19922875
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21834987
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28493397
uniprot
proteins
pubmed
30361697
uniprot
proteins
pubmed
39390519
uniprot
proteins
pubmed
7665558
uniprot
proteins
sequence_length
272
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A9XFX6}. Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:A9XFX6}.
uniprot
proteins