Abhd12
entrez
499913
canonical
uniprot
Q6AYT7
canonical
ensembl
ENSRNOG00000036934
resolver
ensembl
ENSRNOG00055023748
resolver
ensembl
ENSRNOG00060001877
resolver
ensembl
ENSRNOG00065024051
resolver
ensp
ENSRNOP00000010640
resolver
ensp
ENSRNOP00055033122
resolver
ensp
ENSRNOP00060001906
resolver
ensp
ENSRNOP00065033715
resolver
enst
ENSRNOT00000010641
resolver
enst
ENSRNOT00055040781
resolver
enst
ENSRNOT00060002907
resolver
enst
ENSRNOT00065041278
resolver
genesymbol
Abhd12
resolver
uniprot_entry
ABD12_RAT
resolver
amino_acid_sequence
MRKRTEPVTLEHERCAASGSSSSGSAAAALDADCSLKQNLRLAGKGTAEPHSASDAGMKRALGRRKSLWFRLRKILLCVLGFYIAIPFLVKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQGLNHTCNYYLQPEDDVTIGVWHTIPSVWWKNAQGKDQMWYEDALASNHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERETPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENMKHISCPLLILHAEDDPVVPFHLGRKLYNIAAPSRSFRDFKVQFIPFHSDLGYRHKYIYKSPELPRILREFLGKSEPERQH
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
ec_number
3.1.1.-
uniprot
proteins
ec_number
3.1.1.23
uniprot
proteins
function
FUNCTION: Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes (By similarity). Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system (By similarity). Prefers as substrates lysophosphatidylserines having long and very long chain acyl chains (By similarity). Also able to hydrolyze oxidized phosphatidylserine; oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways. Has a strong preference for very-long-chain lipid substrates; substrate specificity is likely due to improved catalysis and not improved substrate binding (By similarity). {ECO:0000250|UniProtKB:Q8N2K0, ECO:0000250|UniProtKB:Q99LR1}.
uniprot
proteins
mass_dalton
45296
uniprot
proteins
protein_family
Serine esterase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
398
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8N2K0}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 75..95; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q99LR1
uniprot
proteins