Atl2
entrez
56298
canonical
uniprot
Q6PA06
canonical
ensembl
ENSMUSG00000059811
resolver
ensp
ENSMUSP00000064758
resolver
ensp
ENSMUSP00000108056
resolver
ensp
ENSMUSP00000247868
resolver
ensp
ENSMUSP00000247869
resolver
ensp
ENSMUSP00000247879
resolver
enst
ENSMUST00000112437
resolver
genesymbol
Atl2
resolver
genesymbol_syn
Arl6ip2
resolver
uniprot
E9QND8
resolver
uniprot
Q3UX01
resolver
uniprot
Q7TMM3
resolver
uniprot
Q8BYP9
resolver
uniprot
Q8C081
resolver
uniprot
Q9D873
resolver
uniprot_entry
ATLA2_MOUSE
resolver
uniprot_entry
E9QND8_MOUSE
resolver
uniprot_entry
Q8BYP9_MOUSE
resolver
uniprot_entry
Q8C081_MOUSE
resolver
uniprot_entry
Q9D873_MOUSE
resolver
uniprot_sec
Q3UX01
resolver
uniprot_sec
Q7TMM3
resolver
amino_acid_sequence
MAEGDEAARRQQPQQGLRRRRQTSDSSVGVNHVSSTTSLGEDYEDDDLVNSDEVMKKPCPVQIVLAHEDDHNFELDEEALEQILLQEHIRDLNIVVVSVAGAFRKGKSFLLDFMLRYMYNKDSQSWIGGNNEPLTGFTWRGGCERETTGIQVWNEVFVIDRPNGTKVAVLLMDTQGAFDSQSTIKDCATVFALSTMTSSVQVYNLSQNIQEDDLQHLQLFTEYGRLAMEEIYQKPFQTLMFLIRDWSYPYEHSYGLEGGKQFLEKRLQVKQNQHEELQNVRKHIHNCFSNLGCFLLPHPGLKVATNPSFDGRLKDIDEDFKRELRNLVPLLLAPENLVEKEISGSKVTCRDLVEYFKAYIKIYQGEELPHPKSMLQATAEANNLAAVAGARDVYCKSMEQVCGGDKPYIAPSDLERKHLDLKEVALKQFRSVKKMGGDEFCRRYQDQLEAEIEETYANFIKHNDGKNIFYAARTPATLFAVMFAMYIISGLTGFIGLNSIAVLCNLVMGLALTSLCTWAYVKYSGEFREIGTMIDQIAETLWEQVLKPLGDNLMEENIRQSVTNSIKAGLTDQVSHHARLKTD
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Atlastin-2 (ATL2) is a membrane-anchored GTPase that mediates the GTP-dependent fusion of endoplasmic reticulum (ER) membranes, maintaining the continuous ER network. It facilitates the formation of three-way junctions where ER tubules intersect (By similarity). Two atlastin-2 on neighboring ER tubules bind GTP and form loose homodimers through the GB1/RHD3-type G domains and 3HB regions. Upon GTP hydrolysis, the 3HB regions tighten, pulling the membranes together to drive their fusion. After fusion, the homodimer disassembles upon release of inorganic phosphate (Pi). Subsequently, GDP dissociates, resetting the monomers to a conformation ready for a new fusion cycle (By similarity). {ECO:0000250|UniProtKB:Q8NHH9, ECO:0000250|UniProtKB:Q8WXF7}.
uniprot
proteins
mass_dalton
66224
uniprot
proteins
protein_family
GB1 subfamily
uniprot
proteins
protein_family
GB1/RHD3 GTPase family
uniprot
proteins
protein_family
TRAFAC class dynamin-like GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19665976
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
583
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8NHH9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8NHH9}. Note=Localizes at endoplasmic reticulum (ER) three-way tubular junctions. {ECO:0000250|UniProtKB:Q8NHH9}.
uniprot
proteins
transmembrane_region
TRANSMEM 477..497; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 500..520; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins