Cep135
entrez
381644
canonical
uniprot
Q6P5D4
canonical
ensembl
ENSMUSG00000036403
resolver
ensp
ENSMUSP00000038674
resolver
ensp
ENSMUSP00000112602
resolver
enst
ENSMUST00000049060
resolver
enst
ENSMUST00000121979
resolver
genesymbol
Cep135
resolver
genesymbol_syn
Cep4
resolver
genesymbol_syn
Kiaa0635
resolver
uniprot
Q6A030
resolver
uniprot_entry
CP135_MOUSE
resolver
uniprot_sec
Q6A030
resolver
amino_acid_sequence
MTTAAERKYINIRKRLDQLGYRQTLSVDSLPLVEKLFSDLVHTTESLRQCRLSSGKAEKESANLDFVLEPYKLENTRLNKENNELYLELMKLRECSDKHIKDLKTTLKKCSRETADLKFLNNQYVHKVKVLEKESKAKDEKIQQLQEKNLRAVVQTPGGRKRNIAFRRQRMQIDEPAPPSEVSAYPVPQPEDPYIADLLQVADNRIQELQEEVQQLQEKLAQMEKGVLDYSKQIELREREIQRLSLALDGGCSPDVLSLETRNKTNEKLIAHLNVQVDFLQQANKELEKHIQELMETKETVTTEVVNLSNRNEKLCQELTEIDQLAQRLERHKEQVLETADKELGEAKKEIKRNLCEMRNLEEKMSKLQWELDLSHKEKERLNSELLLKSDLETVVHQLEQEKQRLSKKLQSFAVTERELTLEVERMRLEHGIKRRDKSPSRLDTFLKGIEEERDYYKKELEKLQHLIQRRSCAINYSAREKPPVVKCSEKGDCSTDVHLITRERDELQRMLERFEKYMEDIQSNVKLLTAERDKLNVLYKEAKEELSTLRKESTNSTSPNHLVSCVEKEKERALSELRRITAEKEALREKLKNIQERNAVGKSDLEKTIEHLTYINHQLENEKYELQSKMLMMKETVESLENKSKLQAQKLSHVTGDSSHQKTEMTSLRIVSEQLQRSLDDCQHRLSIKRGELESAQEQIKMLEQKLENLSHRMTVQSEETHAMKKTIGVMDKEKDFLQETVDEKTEKIANLQESLLSKEKVIAQLKVTVAEYETSLNQLQETLTTRDREINSLRRQLDASHKELDDVGKSREISFKENRRLQDDLATMARENQEISLELEAAVQEKEEMKSRVHKYITEVSRWESLMAAKEKENKDLLDRFQMLHSRAEDWEVKAQQAEGENSSVRLELLSIDTERRHLRERVDLLEKEIQEHINAHHAYESQISSMAKAMSQLEEELRRHESEKATMLGDVSSLRELCIKLDSGKDVMTQQLNSKSLELERAVAELENVKSESELLKKQLTNERQTIKNLESLLATNRDKEFQSHLTSHEKDTEIQLLKEKLNLSESKLTTQSRETSMLRTKVTQLQTDYDNLKRQMSNEKYERERAIQEMRRLGLPTSPLSSTLKSPVQTPDHINA
uniprot
proteins
function
FUNCTION: Centrosomal microtubule-binding protein involved in centriole biogenesis. Acts as a scaffolding protein during early centriole biogenesis. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP and CEP290 and recruitment of WRAP73 to centrioles. Also required for centriole-centriole cohesion during interphase by acting as a platform protein for CEP250 at the centriole. Required for the recruitment of CEP295 to the proximal end of new-born centrioles at the centriolar microtubule wall during early S phase in a PLK4-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q66GS9}.
uniprot
proteins
mass_dalton
133345
uniprot
proteins
protein_family
CEP135/TSGA10 family
uniprot
proteins
pubmed
11781336
uniprot
proteins
pubmed
14983524
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1140
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:11781336}. Note=During centriole biogenesis, it is concentrated within the proximal lumen of both parental centrioles and procentrioles. {ECO:0000250|UniProtKB:Q66GS9}.
uniprot
proteins