Ccdc57
entrez
71276
canonical
uniprot
Q6PHN1
canonical
ensembl
ENSMUSG00000048445
resolver
ensp
ENSMUSP00000050996
resolver
ensp
ENSMUSP00000215946
resolver
enst
ENSMUST00000056781
resolver
genesymbol
Ccdc57
resolver
uniprot_entry
CCD57_MOUSE
resolver
amino_acid_sequence
MLPLCSERELNELLARKEEEWRVLQAHRAQLQEAALQAAQNRLEETQGKLQRLQEDFVYNLQVLEERDRELERYDVEFTQARQREEAQQAEASELKIEVAKLKQDLTREARRVGELQHQHQLMLQEHRLELERVHSDKNSELAHQREQNERLEWELERKLKELDGELALQRQELLLEFESKMQRREHEFQLRADDMSNVVLTHELKIKLLNKELQALRDAGARAAESLQKAEAEHVELERKLQERARELQDLEAVKDARIKGLEKKLYSAQLAKKKAEETFRRKHEELDRQAREKDTVLAAVKRAHAEELQTLDAKVLELQFLCETLEGQLRRAECTRAEDAKEKNALTDKFREDAAALKAAWDAQITQMSKETVSKDFQIHTLQEEEMKLKAQVARFQQDIDRYKQQLSLAVERGQSLEREQVQLGLDWQRRCDDIERDQIQKSETLIEGLTKARDQVAAKLQETEKALRQQETLLKAVSLERDQAMETLRTHGLLPGQEAQVPPQQHEGEIRADSPSTEIQRLQEQNAGLRNAVSQMRREMEMLSGHLPPAQPEECSNADPDPKAGGDSTPPDYVLTLEAEMQNLKHKLKALEEQLQSTEEPVKTSVATADPHHGVHSSAAAADAALADQTSTALALRKLGDRVHLLNLLVTQLKRKLRQKPRELVPVQHEVPSEVDQVHLEVLELQKQVAELRKHLKVTPQGEPSSREQLQRQGVADRYPMGMEDQTESPTFPQEGAQPPQTIYVTHLQRKLKDAARKILSLRLEREQLLEMGNRLRAEQGHAKGKPTPCPGPPTSEPQDPQEVPERSLDRGPPLGQLQPYSTTQDPRHTKRRCASEYAGKSQPHSAQVGSKTNTPRGHKAEMASRPAQLSQKQHRIPTETWKPVYQKENRTPKLPQAHEVPEESDHRTHRSSSLASSSLQDIWRLLELGSSPSGVPSQDNSVAECPAPSRPSCFQKVNRSPVPIQKAFAVKGLKMEAQPKATPPRPSKSHPAKPTNCQQQRPSRIRNYNLKD
uniprot
proteins
function
FUNCTION: Pleiotropic regulator of centriole duplication, mitosis, and ciliogenesis (PubMed:32402286). Critical interface between centrosome and microtubule-mediated cellular processes. Centriole duplication protein required for recruitment of CEP63, CEP152, and PLK4 to the centrosome. Independent of its centrosomal targeting, localizes to and interacts with microtubules and regulates microtubule nucleation, stability, and mitotic progression (By similarity). {ECO:0000250|UniProtKB:Q2TAC2, ECO:0000269|PubMed:32402286}.
uniprot
proteins
mass_dalton
116194
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32402286
uniprot
proteins
sequence_length
1016
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q2TAC2}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000250|UniProtKB:Q2TAC2}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q2TAC2}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q2TAC2}. Note=Localizes to resolvable rings at the proximal end of centrioles. In mitotic cells, localizes to spindle microtubules during metaphase. {ECO:0000250|UniProtKB:Q2TAC2}.
uniprot
proteins