CYP4F2
entrez
8529
canonical
uniprot
P78329
canonical
ensembl
ENSG00000186115
resolver
ensp
ENSP00000221700
resolver
genesymbol
CYP4F2
resolver
hgnc
HGNC:2645
resolver
uniprot
A0A024R7K3
resolver
uniprot
A8K425
resolver
uniprot
B4DV75
resolver
uniprot
Q16677
resolver
uniprot
Q6NWT4
resolver
uniprot
Q6NWT6
resolver
uniprot
Q9NNZ0
resolver
uniprot
Q9UIU8
resolver
uniprot_entry
CP4F2_HUMAN
resolver
uniprot_sec
A0A024R7K3
resolver
uniprot_sec
A8K425
resolver
uniprot_sec
B4DV75
resolver
uniprot_sec
Q16677
resolver
uniprot_sec
Q6NWT4
resolver
uniprot_sec
Q6NWT6
resolver
uniprot_sec
Q9NNZ0
resolver
uniprot_sec
Q9UIU8
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by dietary sesamin. {ECO:0000269|PubMed:11997390}.
uniprot
proteins
amino_acid_sequence
MSQLSLSWLGLWPVAASPWLLLLLVGASWLLAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAEGGLWLRVEPLS
uniprot
proteins
disease_involvement
DISEASE: Coumarin resistance (CMRES) [MIM:122700]: A condition characterized by partial or complete resistance to warfarin or other 4-hydroxycoumarin derivatives. These drugs are used as anti-coagulants for the prevention of thromboembolic diseases in subjects with deep vein thrombosis, atrial fibrillation, or mechanical heart valve replacement. {ECO:0000269|PubMed:18250228, ECO:0000269|PubMed:19207028, ECO:0000269|PubMed:19270263, ECO:0000269|PubMed:19297519, ECO:0000269|PubMed:20555338, ECO:0000269|PubMed:23132553, ECO:0000269|PubMed:24138531}. Note=Disease susceptibility may be associated with variants affecting the gene represented in this entry. The variant Met-433 is associated with coumarin (the brand name of warfarin) resistance by increasing coumarin maintenance dose in patients on this anti-coagulant therapy. This is probably due to decreased activity of the phylloquinone omega-hydroxylase activity, leading to an increase in hepatic vitamin K levels that warfarin must antagonize (PubMed:24138531). {ECO:0000269|PubMed:24138531}.
uniprot
proteins
ec_number
1.14.14.1
uniprot
proteins
ec_number
1.14.14.78
uniprot
proteins
ec_number
1.14.14.79
uniprot
proteins
ec_number
1.14.14.94
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, eicosanoids and vitamins (PubMed:10660572, PubMed:10833273, PubMed:11997390, PubMed:17341693, PubMed:18574070, PubMed:18577768). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of long- and very long-chain fatty acids. Displays high omega-hydroxylase activity toward polyunsaturated fatty acids (PUFAs) (PubMed:18577768). Participates in the conversion of arachidonic acid to omega-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:10660572, PubMed:17341693, PubMed:18574070). Plays a role in the oxidative inactivation of eicosanoids, including both pro-inflammatory and anti-inflammatory mediators such as leukotriene B4 (LTB4), lipoxin A4 (LXA4), and several HETEs (PubMed:10660572, PubMed:10833273, PubMed:17341693, PubMed:18574070, PubMed:18577768, PubMed:8026587, PubMed:9799565). Catalyzes omega-hydroxylation of 3-hydroxy fatty acids (PubMed:18065749). Converts monoepoxides of linoleic acid leukotoxin and isoleukotoxin to omega-hydroxylated metabolites (PubMed:15145985). Contributes to the degradation of very long-chain fatty acids (VLCFAs) by catalyzing successive omega-oxidations and chain shortening (PubMed:16547005, PubMed:18182499). Plays an important role in vitamin metabolism by chain shortening. Catalyzes omega-hydroxylation of the phytyl chain of tocopherols (forms of vitamin E), with preference for gamma-tocopherols over alpha-tocopherols, thus promoting retention of alpha-tocopherols in tissues (PubMed:11997390). Omega-hydroxylates and inactivates phylloquinone (vitamin K1), and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulation (PubMed:19297519, PubMed:24138531). {ECO:0000269|PubMed:10660572, ECO:0000269|PubMed:10833273, ECO:0000269|PubMed:11997390, ECO:0000269|PubMed:15145985, ECO:0000269|PubMed:16547005, ECO:0000269|PubMed:17341693, ECO:0000269|PubMed:18065749, ECO:0000269|PubMed:18182499, ECO:0000269|PubMed:18574070, ECO:0000269|PubMed:18577768, ECO:0000269|PubMed:19297519, ECO:0000269|PubMed:24138531, ECO:0000269|PubMed:8026587, ECO:0000269|PubMed:9799565}.
uniprot
proteins
mass_dalton
59853
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; arachidonate metabolism. {ECO:0000269|PubMed:10833273}.; PATHWAY: Lipid metabolism; leukotriene B4 degradation. {ECO:0000269|PubMed:10833273}.; PATHWAY: Cofactor degradation; phylloquinone degradation. {ECO:0000269|PubMed:24138531}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
10492403
uniprot
proteins
pubmed
10660572
uniprot
proteins
pubmed
10833273
uniprot
proteins
pubmed
10860554
uniprot
proteins
pubmed
11997390
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15145985
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16547005
uniprot
proteins
pubmed
17341693
uniprot
proteins
pubmed
18065749
uniprot
proteins
pubmed
18182499
uniprot
proteins
pubmed
18250228
uniprot
proteins
pubmed
18574070
uniprot
proteins
pubmed
18577768
uniprot
proteins
pubmed
19207028
uniprot
proteins
pubmed
19270263
uniprot
proteins
pubmed
19297519
uniprot
proteins
pubmed
20555338
uniprot
proteins
pubmed
20861217
uniprot
proteins
pubmed
23132553
uniprot
proteins
pubmed
24138531
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8026587
uniprot
proteins
pubmed
9799565
uniprot
proteins
sequence_length
520
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000269|PubMed:19297519, ECO:0000269|PubMed:24138531, ECO:0000269|PubMed:8026587}; Peripheral membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20861217}; Peripheral membrane protein {ECO:0000305}.
uniprot
proteins