CDK2AP1
entrez
8099
canonical
uniprot
O14519
canonical
ensembl
ENSG00000111328
resolver
ensp
ENSP00000261692
resolver
ensp
ENSP00000442502
resolver
ensp
ENSP00000479982
resolver
genesymbol
CDK2AP1
resolver
genesymbol_syn
CDKAP1
resolver
genesymbol_syn
DOC1
resolver
hgnc
HGNC:14002
resolver
uniprot
F5GYA4
resolver
uniprot_entry
CDKA1_HUMAN
resolver
uniprot_sec
F5GYA4
resolver
amino_acid_sequence
MSYKPNLAAHMPAAALNAAGSVHSPSTSMATSSQYRQLLSDYGPPSLGYTQGTGNSQVPQSKYAELLAIIEELGKEIRPTYAGSKSAMERLKRGIIHARGLVRECLAETERNARS
uniprot
proteins
function
FUNCTION: Inhibitor of cyclin-dependent kinase CDK2 (By similarity). Also acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:20523938, PubMed:28977666). {ECO:0000250|UniProtKB:O35207, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:20523938, ECO:0000269|PubMed:28977666}.
uniprot
proteins
mass_dalton
12365
uniprot
proteins
mutagenesis
MUTAGEN 105; /note="C->A: Does not alter homodimerization."; /evidence="ECO:0000269|PubMed:22427660
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in vitro by IKBKE at Ser-46. {ECO:0000269|PubMed:22427660}.
uniprot
proteins
protein_family
CDK2AP family
uniprot
proteins
pubmed
14985111
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16428440
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
20523938
uniprot
proteins
pubmed
22427660
uniprot
proteins
pubmed
28977666
uniprot
proteins
pubmed
33283408
uniprot
proteins
pubmed
9331572
uniprot
proteins
pubmed
9506968
uniprot
proteins
sequence_length
115
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20523938, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:33283408}. Chromosome {ECO:0000269|PubMed:20523938}.
uniprot
proteins