FHL2
entrez
2274
canonical
uniprot
Q14192
canonical
ensembl
ENSG00000115641
resolver
ensp
ENSP00000322909
resolver
ensp
ENSP00000344266
resolver
ensp
ENSP00000377020
resolver
ensp
ENSP00000377021
resolver
ensp
ENSP00000386633
resolver
ensp
ENSP00000386892
resolver
ensp
ENSP00000433567
resolver
ensp
ENSP00000546162
resolver
genesymbol
FHL2
resolver
genesymbol_syn
DRAL
resolver
genesymbol_syn
SLIM3
resolver
hgnc
HGNC:3703
resolver
uniprot
D3DVK0
resolver
uniprot
Q13229
resolver
uniprot
Q13644
resolver
uniprot
Q2I5I4
resolver
uniprot
Q2XQU9
resolver
uniprot
Q561W1
resolver
uniprot
Q5TM15
resolver
uniprot
Q6I9R8
resolver
uniprot
Q9P294
resolver
uniprot_entry
FHL2_HUMAN
resolver
uniprot_entry
Q2XQU9_HUMAN
resolver
uniprot_entry
Q6I9R8_HUMAN
resolver
uniprot_sec
D3DVK0
resolver
uniprot_sec
Q13229
resolver
uniprot_sec
Q13644
resolver
uniprot_sec
Q2I5I4
resolver
uniprot_sec
Q561W1
resolver
uniprot_sec
Q5TM15
resolver
uniprot_sec
Q9P294
resolver
amino_acid_sequence
MTERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQPWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDCGKDI
uniprot
proteins
function
FUNCTION: May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation. Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes (PubMed:28717008). {ECO:0000269|PubMed:15692560, ECO:0000269|PubMed:16652157, ECO:0000269|PubMed:18853468, ECO:0000269|PubMed:28717008}.
uniprot
proteins
mass_dalton
32193
uniprot
proteins
pubmed
11001931
uniprot
proteins
pubmed
11813260
uniprot
proteins
pubmed
12432079
uniprot
proteins
pubmed
15453830
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15692560
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16652157
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18853468
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22851699
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
28717008
uniprot
proteins
pubmed
8753811
uniprot
proteins
pubmed
9150430
uniprot
proteins
pubmed
9573400
uniprot
proteins
sequence_length
279
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11813260, ECO:0000269|PubMed:16652157}. Nucleus {ECO:0000269|PubMed:11813260, ECO:0000269|PubMed:16652157}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:O35115}.
uniprot
proteins