ADIG
entrez
149685
canonical
uniprot
Q0VDE8
canonical
ensembl
ENSG00000182035
resolver
ensp
ENSP00000416834
resolver
ensp
ENSP00000434385
resolver
ensp
ENSP00000440331
resolver
enst
ENST00000416116
resolver
enst
ENST00000470147
resolver
enst
ENST00000537425
resolver
genesymbol
ADIG
resolver
hgnc
HGNC:28606
resolver
uniprot
A0A158RFT8
resolver
uniprot
H0Y829
resolver
uniprot_entry
A0A158RFT8_HUMAN
resolver
uniprot_entry
ADIG_HUMAN
resolver
uniprot_entry
H0Y829_HUMAN
resolver
amino_acid_sequence
MKYPLMPLVNDLTFSFLVFWFCLPVGLLLLLIIWLRFLLSQDSEENDSSVCLDWEPWSKGPAEFCWKGTLHGQEKERPCW
uniprot
proteins
function
FUNCTION: Key regulator of lipid storage that promotes the expansion of lipid droplets during the formation of mature adipocytes. Acts by forming a dodecameric complex with seipin (BSCL2) when adipocytes have differentiated and are undergoing maturation. In the dodecameric complex, ADIG antagonizes the activity of BSCL2 by reducing BSCL2-mediated triacylglycerol nucleation and relieving BSCL2's inhibition of GPAT3 and GPAT4. GPAT3 and GPAT4 then translocate to lipid droplets, promoting the synthesis of triacylglycerols and the expansion of lipid droplets. {ECO:0000250|UniProtKB:Q8R400}.
uniprot
proteins
mass_dalton
9465
uniprot
proteins
protein_family
Adipogenin family
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
80
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8R400}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q8R400}.
uniprot
proteins
transmembrane_region
TRANSMEM 14..38; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q8R400
uniprot
proteins