TFDP3
entrez
51270
canonical
uniprot
Q5H9I0
canonical
ensembl
ENSG00000183434
resolver
ensp
ENSP00000385461
resolver
enst
ENST00000310125
resolver
genesymbol
TFDP3
resolver
genesymbol_syn
DP4
resolver
genesymbol_syn
HCA661
resolver
hgnc
HGNC:24603
resolver
uniprot
Q6DK49
resolver
uniprot
Q9NZ54
resolver
uniprot_entry
TFDP3_HUMAN
resolver
uniprot_sec
Q6DK49
resolver
uniprot_sec
Q9NZ54
resolver
amino_acid_sequence
MAKYVSLTEANEELKVLMDENQTSRPVAVHTSTVNPLGKQLLPKTFGQSSVNIDQQVVIGMPQRPAASNIPVVGSPNPPSTHFASQNQHSYSSPPWAGQHNRKGEKNGMGLCRLSMKVWETVQRKGTTSCQEVVGELVAKFRAASNHASPNESAYDVKNIKRRTYDALNVLMAMNIISREKKKIKWIGLTTNSAQNCQNLRVERQKRLERIKQKQSELQQLILQQIAFKNLVLRNQYVEEQVSQRPLPNSVIHVPFIIISSSKKTVINCSISDDKSEYLFKFNSSFEIHDDTEVLMWMGMTFGLESGSCSAEDLKMARNLVPKALEPYVTEMAQGTFGGVFTTAGSRSNGTWLSASDLTNIAIGMLATSSGGSQYSGSRVETPAVEEEEEEDNNDDDLSENDEDD
uniprot
proteins
function
FUNCTION: Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G(1) to S phase. {ECO:0000269|PubMed:16418725, ECO:0000269|PubMed:17062573, ECO:0000269|PubMed:20559320}.
uniprot
proteins
mass_dalton
44967
uniprot
proteins
mutagenesis
MUTAGEN 112; /note="C->R: No effect on down-regulation of E2F transcriptional activity; when associated with or without R-161 or with V-164."; MUTAGEN 121; /note="T->K: Restores enhanced E2F-mediated transcriptional activity; when associated with Y-130; N-131 and E-145."; /evidence="ECO:0000269|PubMed:17062573"; MUTAGEN 130; /note="C->Y: Restores enhanced E2F-mediated transcriptional activity; when associated with K-121; N-131 and E-145."; /evidence="ECO:0000269|PubMed:17062573"; MUTAGEN 131; /note="Q->N: Restores enhanced E2F-mediated transcriptional activity; when associated with K-121; Y-130 and E-145."; /evidence="ECO:0000269|PubMed:17062573"; MUTAGEN 140; /note="K->E: Restores enhanced E2F-mediated transcriptional activity; when associated with K-121; Y-130 and N-131."; /evidence="ECO:0000269|PubMed:17062573"; MUTAGEN 161; /note="K->R: No effect on down-regulation of E2F transcriptional activity; when associated with or without R-112."; MUTAGEN 164; /note="T->V: No effect on down-regulation of E2F transcriptional activity; when associated R-112.
uniprot
proteins
protein_family
E2F/DP family
uniprot
proteins
pubmed
12097419
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
16418725
uniprot
proteins
pubmed
17062573
uniprot
proteins
pubmed
20559320
uniprot
proteins
sequence_length
405
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Translocates to the nucleus on heterodimerization with E2F family members.
uniprot
proteins