Gtf2b
entrez
229906
canonical
uniprot
P62915
canonical
ensembl
ENSMUSG00000028271
resolver
ensp
ENSMUSP00000029938
resolver
enst
ENSMUST00000029938
resolver
genesymbol
Gtf2b
resolver
uniprot
P29053
resolver
uniprot
Q3ULN2
resolver
uniprot_entry
Q3ULN2_MOUSE
resolver
uniprot_entry
TF2B_MOUSE
resolver
uniprot_sec
P29053
resolver
amino_acid_sequence
MASTSRLDALPRVTCPNHPDAILVEDYRAGDMICPECGLVVGDRVIDVGSEWRTFSNDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRTMSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLITTGDFMSRFCSNLCLPKQVQMAATHIARKAVELDLVPGRSPISVAAAAIYMASQASAEKRTQKEIGDIAGVADVTIRQSYRLIYPRAPDLFPSDFKFDTPVDKLPQL
uniprot
proteins
ec_number
2.3.1.48
uniprot
proteins
function
FUNCTION: General transcription factor that plays a role in transcription initiation by RNA polymerase II (Pol II). Involved in the pre-initiation complex (PIC) formation and Pol II recruitment at promoter DNA. Together with the TATA box-bound TBP forms the core initiation complex and provides a bridge between TBP and the Pol II-TFIIF complex. Released from the PIC early following the onset of transcription during the initiation and elongation transition and reassociates with TBP during the next transcription cycle. Associates with chromatin to core promoter-specific regions. Binds to two distinct DNA core promoter consensus sequence elements in a TBP-independent manner; these IIB-recognition elements (BREs) are localized immediately upstream (BREu), 5'-[GC][GC][GA]CGCC-3', and downstream (BREd), 5'-[GA]T[TGA][TG][GT][TG][TG]-3', of the TATA box element. Modulates transcription start site selection. Also exhibits autoacetyltransferase activity that contributes to the activated transcription. {ECO:0000250|UniProtKB:Q00403}.
uniprot
proteins
mass_dalton
34819
uniprot
proteins
post_translational_modification
PTM: Acetylated. Autoacetylated; autoacetylation at Lys-238 stimulates transcription activation. {ECO:0000250|UniProtKB:Q00403}.
uniprot
proteins
protein_family
TFIIB family
uniprot
proteins
pubmed
14612417
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
316
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q00403}. Chromosome {ECO:0000250|UniProtKB:Q00403}. Note=Non-acetylated form colocalizes with DNA in the G0/1, S and G2 phases of the cell cycle, but not during mitosis. Acetylated form colocalizes at transcriptionally silent mitotic chromatids during mitosis at metaphase, anaphase, and telophase phases of the cell cycle. {ECO:0000250|UniProtKB:Q00403}.
uniprot
proteins