Dgat2
entrez
252900
canonical
uniprot
Q5FVP8
canonical
ensembl
ENSRNOG00000016573
resolver
ensembl
ENSRNOG00055030578
resolver
ensembl
ENSRNOG00060002691
resolver
ensembl
ENSRNOG00065023408
resolver
ensp
ENSRNOP00000022557
resolver
ensp
ENSRNOP00055043893
resolver
ensp
ENSRNOP00060003018
resolver
ensp
ENSRNOP00065032579
resolver
enst
ENSRNOT00000022557
resolver
enst
ENSRNOT00055053101
resolver
enst
ENSRNOT00060004308
resolver
enst
ENSRNOT00065040075
resolver
genesymbol
Dgat2
resolver
uniprot
Q8K4Y4
resolver
uniprot_entry
DGAT2_RAT
resolver
uniprot_sec
Q8K4Y4
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by niacin. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MKTLIAAYSGVLRGERRAEAARSENKNKGSALSREGSGRWGTGSSILSALQDIFSVTWLNRSKVEKHLQVISVLQWVLSFLVLGVACSVILMYTFCTDCWLIAALYFTWLAFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVNRDTIDYLLSKNGSGNAIVIVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLVPTYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITVPKLEHPTQKDIDLYHTMYMEALVKLFDNHKTKFGLPETEVLEVN
uniprot
proteins
ec_number
2.3.1.20
uniprot
proteins
ec_number
2.3.1.76
uniprot
proteins
function
FUNCTION: Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides (By similarity). Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides (By similarity). Also functions as an acyl-CoA retinol acyltransferase (ARAT) (By similarity). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (By similarity). {ECO:0000250|UniProtKB:Q96PD7, ECO:0000250|UniProtKB:Q9DCV3}.
uniprot
proteins
mass_dalton
43795
uniprot
proteins
pathway_participation
PATHWAY: Glycerolipid metabolism; triacylglycerol biosynthesis.
uniprot
proteins
protein_family
Diacylglycerol acyltransferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
388
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q96PD7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96PD7}. Lipid droplet {ECO:0000250|UniProtKB:Q96PD7}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q96PD7}.
uniprot
proteins
transmembrane_region
TRANSMEM 70..88; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 93..112; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins