Bin1
entrez
30948
canonical
uniprot
O08539
canonical
ensembl
ENSMUSG00000024381
resolver
ensp
ENSMUSP00000025239
resolver
ensp
ENSMUSP00000089590
resolver
ensp
ENSMUSP00000156976
resolver
ensp
ENSMUSP00000157259
resolver
ensp
ENSMUSP00000159972
resolver
ensp
ENSMUSP00000304609
resolver
ensp
ENSMUSP00000304610
resolver
ensp
ENSMUSP00000304612
resolver
ensp
ENSMUSP00000304613
resolver
ensp
ENSMUSP00000304614
resolver
ensp
ENSMUSP00000304615
resolver
ensp
ENSMUSP00000304616
resolver
ensp
ENSMUSP00000304617
resolver
ensp
ENSMUSP00000304619
resolver
ensp
ENSMUSP00000304625
resolver
ensp
ENSMUSP00000304626
resolver
ensp
ENSMUSP00000304648
resolver
ensp
ENSMUSP00000304649
resolver
ensp
ENSMUSP00000304682
resolver
ensp
ENSMUSP00000304688
resolver
enst
ENSMUST00000091967
resolver
enst
ENSMUST00000234496
resolver
enst
ENSMUST00000249875
resolver
genesymbol
Bin1
resolver
genesymbol_syn
Amphl
resolver
genesymbol_syn
Sh3p9
resolver
uniprot
A0A3Q4EBK4
resolver
uniprot
A0AAQ4VMS1
resolver
uniprot
F6UNF5
resolver
uniprot
Q62434
resolver
uniprot
Q6P1B9
resolver
uniprot_entry
A0A3Q4EBK4_MOUSE
resolver
uniprot_entry
A0AAQ4VMS1_MOUSE
resolver
uniprot_entry
BIN1_MOUSE
resolver
uniprot_entry
F6UNF5_MOUSE
resolver
uniprot_entry
Q6P1B9_MOUSE
resolver
uniprot_sec
Q62434
resolver
amino_acid_sequence
MAEMGSKGVTAGKIASNVQKKLTRAQEKVLQKLGKADETKDEQFEQCVQNFNKQLTEGTRLQKDLRTYLASVKAMHEASKKLSECLQEVYEPEWPGRDEANKIAENNDLLWMDYHQKLVDQALLTMDTYLGQFPDIKSRIAKRGRKLVDYDSARHHYESLQTAKKKDEAKIAKPVSLLEKAAPQWCQGKLQAHLVAQTNLLRNQAEEELIKAQKVFEEMNVDLQEELPSLWNSRVGFYVNTFQSIAGLEENFHKEMSKLNQNLNDVLVSLEKQHGSNTFTVKAQPSDNAPEKGNKSPSPPPDGSPAATPEIRVNHEPEPASGASPGATIPKSPSQLRKGPPVPPPPKHTPSKEMKQEQILSLFDDAFVPEISVTTPSQFEAPGPFSEQASLLDLDFEPLPPVASPVKAPTPSGQSIPWDLWEPTESQAGILPSGEPSSAEGSFAVAWPSQTAEPGPAQPAEASEVVGGAQEPGETAASEATSSSLPAVVVETFSATVNGAVEGSAGTGRLDLPPGFMFKVQAQHDYTATDTDELQLKAGDVVLVIPFQNPEEQDEGWLMGVKESDWNQHKELEKCRGVFPENFTERVQ
uniprot
proteins
function
FUNCTION: Is a key player in the control of plasma membrane curvature, and membrane shaping and remodeling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling. Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed:12183633). Is a negative regulator of endocytosis (By similarity). Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed:12668730, PubMed:27179792). In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity). May be involved in the regulation of MYC activity and the control cell proliferation (By similarity). {ECO:0000250|UniProtKB:O00499, ECO:0000250|UniProtKB:O08839, ECO:0000269|PubMed:12183633, ECO:0000269|PubMed:12668730, ECO:0000269|PubMed:27179792}.
uniprot
proteins
mass_dalton
64470
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by protein kinase C. {ECO:0000250}.
uniprot
proteins
pubmed
12183633
uniprot
proteins
pubmed
12456676
uniprot
proteins
pubmed
12668730
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27179792
uniprot
proteins
pubmed
8782822
uniprot
proteins
pubmed
9182529
uniprot
proteins
pubmed
9630982
uniprot
proteins
sequence_length
588
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O00499}. Cytoplasm {ECO:0000269|PubMed:12668730}. Endosome {ECO:0000269|PubMed:12668730}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:O08839}.
uniprot
proteins