CHST1
entrez
8534
canonical
uniprot
O43916
canonical
ensembl
ENSG00000175264
resolver
ensp
ENSP00000309270
resolver
ensp
ENSP00000561855
resolver
ensp
ENSP00000561856
resolver
ensp
ENSP00000561857
resolver
ensp
ENSP00000561858
resolver
ensp
ENSP00000561859
resolver
ensp
ENSP00000561860
resolver
ensp
ENSP00000561861
resolver
ensp
ENSP00000561862
resolver
ensp
ENSP00000561863
resolver
ensp
ENSP00000561864
resolver
ensp
ENSP00000561865
resolver
ensp
ENSP00000561866
resolver
ensp
ENSP00000561867
resolver
ensp
ENSP00000561868
resolver
ensp
ENSP00000561869
resolver
ensp
ENSP00000561870
resolver
ensp
ENSP00000561871
resolver
ensp
ENSP00000561872
resolver
ensp
ENSP00000594408
resolver
ensp
ENSP00000594409
resolver
ensp
ENSP00000630388
resolver
ensp
ENSP00000630389
resolver
ensp
ENSP00000630390
resolver
ensp
ENSP00000630391
resolver
ensp
ENSP00000630392
resolver
enst
ENST00000308064
resolver
enst
ENST00000891796
resolver
enst
ENST00000891797
resolver
enst
ENST00000891798
resolver
enst
ENST00000891799
resolver
enst
ENST00000891800
resolver
enst
ENST00000891801
resolver
enst
ENST00000891802
resolver
enst
ENST00000891803
resolver
enst
ENST00000891804
resolver
enst
ENST00000891805
resolver
enst
ENST00000891806
resolver
enst
ENST00000891807
resolver
enst
ENST00000891808
resolver
enst
ENST00000891809
resolver
enst
ENST00000891810
resolver
enst
ENST00000891811
resolver
enst
ENST00000891812
resolver
enst
ENST00000891813
resolver
enst
ENST00000924349
resolver
enst
ENST00000924350
resolver
enst
ENST00000960329
resolver
enst
ENST00000960330
resolver
enst
ENST00000960331
resolver
enst
ENST00000960332
resolver
enst
ENST00000960333
resolver
genesymbol
CHST1
resolver
hgnc
HGNC:1969
resolver
uniprot
D3DQP2
resolver
uniprot_entry
CHST1_HUMAN
resolver
uniprot_sec
D3DQP2
resolver
amino_acid_sequence
MQCSWKAVLLLALASIAIQYTAIRTFTAKSFHTCPGLAEAGLAERLCEESPTFAYNLSRKTHILILATTRSGSSFVGQLFNQHLDVFYLFEPLYHVQNTLIPRFTQGKSPADRRVMLGASRDLLRSLYDCDLYFLENYIKPPPVNHTTDRIFRRGASRVLCSRPVCDPPGPADLVLEEGDCVRKCGLLNLTVAAEACRERSHVAIKTVRVPEVNDLRALVEDPRLNLKVIQLVRDPRGILASRSETFRDTYRLWRLWYGTGRKPYNLDVTQLTTVCEDFSNSVSTGLMRPPWLKGKYMLVRYEDLARNPMKKTEEIYGFLGIPLDSHVARWIQNNTRGDPTLGKHKYGTVRNSAATAEKWRFRLSYDIVAFAQNACQQVLAQLGYKIAASEEELKNPSVSLVEERDFRPFS
uniprot
proteins
ec_number
2.8.2.21
uniprot
proteins
function
FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of internal galactose (Gal) residues of keratan. Cooperates with B4GALT4 and B3GNT7 glycosyltransferases and CHST6 sulfotransferase to construct and elongate disulfated disaccharide unit [->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer (PubMed:10642612, PubMed:17690104, PubMed:9405439). Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer (PubMed:9405439). Involved in biosynthesis of phosphacan, a major keratan sulfate proteoglycan in the developing brain (By similarity). Involved in biosynthesis of 6-sulfoGalbeta-containing O-linked glycans in high endothelial venules of lymph nodes. May act in a synergistic manner with CHST4 to generate sialyl 6',6-disulfo Lewis X motif, a recognition determinant for immune cell receptors implicated in leukocyte trafficking (PubMed:10330415). Catalyzes sulfation of N-acetyllactosamine (LacNAc) oligosaccharides with highest efficiency for sialylated LacNAc structures (PubMed:10642612). {ECO:0000250|UniProtKB:Q9EQC0, ECO:0000269|PubMed:10330415, ECO:0000269|PubMed:10642612, ECO:0000269|PubMed:17690104, ECO:0000269|PubMed:9405439}.
uniprot
proteins
mass_dalton
46715
uniprot
proteins
pathway_participation
PATHWAY: Glycan metabolism. {ECO:0000269|PubMed:17690104}.
uniprot
proteins
protein_family
Gal/GlcNAc/GalNAc subfamily
uniprot
proteins
protein_family
Sulfotransferase 1 family
uniprot
proteins
pubmed
10049591
uniprot
proteins
pubmed
10330415
uniprot
proteins
pubmed
10642612
uniprot
proteins
pubmed
11310842
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17690104
uniprot
proteins
pubmed
9405439
uniprot
proteins
pubmed
9639683
uniprot
proteins
sequence_length
411
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 3..23; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins