Nlgn3
entrez
171297
canonical
uniprot
Q62889
canonical
ensembl
ENSRNOG00000003812
resolver
ensp
ENSRNOP00000005077
resolver
ensp
ENSRNOP00000005102
resolver
ensp
ENSRNOP00000068393
resolver
enst
ENSRNOT00000005077
resolver
enst
ENSRNOT00000005102
resolver
enst
ENSRNOT00000076168
resolver
genesymbol
Nlgn3
resolver
uniprot
A0A096MK63
resolver
uniprot
D3ZDC0
resolver
uniprot
F1LPZ8
resolver
uniprot_entry
A0A096MK63_RAT
resolver
uniprot_entry
D3ZDC0_RAT
resolver
uniprot_entry
F1LPZ8_RAT
resolver
uniprot_entry
NLGN3_RAT
resolver
amino_acid_sequence
MWLQLGLPSLSLSPTPTVGRSLCLILWFLSLVLRASTQAPAPTVNTHFGKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQNIHTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVYVPTEDVKRISKECARKPNKKICRKGGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSVLASYGNVIVITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADKVGCNVLDTVDMVDCLRQKSAKELVEQDIQPARYHVAFGPVIDGDVIPDDPEILMEQGEFLNYDIMLGVNQGEGLKFVEGVVDPEDGVSGTDFDYSVSNFVDNLYGYPEGKDTLRETIKFMYTDWADRDNPETRRKTLVALFTDHQWVEPSVVTADLHARYGSPTYFYAFYHHCQSLMKPAWSDAAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNKPVPQDTKFIHTKANRFEEVAWSKYNPRDQLYLHIGLKPRVRDHYRATKVAFWKHLVPHLYNLHDMFHYTSTTTKVPPPDTTHSSHITRRPNGKTWSTKRPAISPAYSNENAPGSWNGDQDAGPLLVENPRDYSTELSVTIAVGASLLFLNVLAFAALYYRKDKRRQEPLRQPSPQRGTGAPELGTAPEEELAALQLGPTHHECEAGPPHDTLRLTALPDYTLTLRRSPDDIPLMTPNTITMIPNSLVGLQTLHPYNTFAAGFNSTGLPNSHSTTRV
uniprot
proteins
function
FUNCTION: Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and probably mediates its effects by recruiting and clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system. {ECO:0000269|PubMed:17897391}.
uniprot
proteins
mass_dalton
93888
uniprot
proteins
mutagenesis
MUTAGEN 451; /note="R->C: Impaired cell surface expression, and reduced interaction with NRXN1."; /evidence="ECO:0000269|PubMed:15152050
uniprot
proteins
post_translational_modification
PTM: N-glycosylated, contains high-mannose, hybrid, complex and sialylated N-glycans. N-glycosylation is essential for localization to synapses, dendrites, and the cell membrane, and enhances its availability for trans-synaptic adhesion. O-glycosylated. {ECO:0000250|UniProtKB:Q8BYM5}.; PTM: The N-terminus is blocked.
uniprot
proteins
protein_family
Type-B carboxylesterase/lipase family
uniprot
proteins
pubmed
11329178
uniprot
proteins
pubmed
15152050
uniprot
proteins
pubmed
16982420
uniprot
proteins
pubmed
17897391
uniprot
proteins
pubmed
18755801
uniprot
proteins
pubmed
19914352
uniprot
proteins
pubmed
20624592
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8576240
uniprot
proteins
sequence_length
848
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15152050}; Single-pass type I membrane protein {ECO:0000255}. Synapse {ECO:0000269|PubMed:17897391}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8BYM5}. Note=Detected at both glutamatergic and GABAergic synapses. Localizes to dendritic membrane (By similarity). {ECO:0000250|UniProtKB:Q8BYM5, ECO:0000269|PubMed:17897391}.
uniprot
proteins
transmembrane_region
TRANSMEM 710..730; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins