Chrnb3
entrez
171131
canonical
uniprot
P12391
canonical
ensembl
ENSRNOG00000012448
resolver
ensembl
ENSRNOG00055007994
resolver
ensembl
ENSRNOG00060012244
resolver
ensembl
ENSRNOG00065002722
resolver
ensp
ENSRNOP00000016656
resolver
ensp
ENSRNOP00055010797
resolver
ensp
ENSRNOP00060016355
resolver
ensp
ENSRNOP00065002584
resolver
enst
ENSRNOT00000016656
resolver
enst
ENSRNOT00055013476
resolver
enst
ENSRNOT00060020760
resolver
enst
ENSRNOT00065003705
resolver
genesymbol
Chrnb3
resolver
genesymbol_syn
Acrb3
resolver
uniprot_entry
ACHB3_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by a myriad of ligands such as acetylcholine, cytisine, nicotine, choline and epibatidine. {ECO:0000250|UniProtKB:Q05901}.
uniprot
proteins
amino_acid_sequence
MTGFLRVFLVLSATLSGSWVTLTATAGLSSVAEHEDALLRHLFQGYQKWVRPVLNSSDIIKVYFGLKISQLVDVDEKNQLMTTNVWLKQEWTDQKLRWNPEEYGGINSIKVPSESLWLPDIVLFENADGRFEGSLMTKAIVKSSGTVSWTPPASYKSSCTMDVTFFPFDRQNCSMKFGSWTYDGTMVDLILINENVDRKDFFDNGEWEILNAKGMKGNRREGFYSYPFVTYSFVLRRLPLFYTLFLIIPCLGLSFLTVLVFYLPSDEGEKLSLSTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLLFIMIFVTLSIIVTVFVINVHHRSSSTYHPMAPWVKRLFLQRLPRWLCMKDPMDRFSFPDGKESDTAVRGKVSGKRKQTPASDGERVLVAFLEKASESIRYISRHVKKEHFISQVVQDWKFVAQVLDRIFLWLFLIASVLGSILIFIPALKMWIHRFH
uniprot
proteins
function
FUNCTION: Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. Has an accessory rather than functional role and is only able to form functional nAChRs when co-assembled with another beta subunit. Participates in pentameric assemblies along with CHRNA3, CHRNA4, CHRNA6, CHRNB2 and CHRNB4. Modulates receptor assembly and increases receptor sensitivity to nicotine when associated with CHRNB2, CHRNA4 and/or CHRNA6 as well as CHRNA3 and CHRNB4. Seems to play a role in nicotine addiction. {ECO:0000250|UniProtKB:Q05901}.
uniprot
proteins
mass_dalton
53261
uniprot
proteins
protein_family
Acetylcholine receptor (TC 1.A.9.1) subfamily
uniprot
proteins
protein_family
Beta-3/CHRNB3 sub-subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
2703489
uniprot
proteins
sequence_length
464
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Synaptic cell membrane {ECO:0000250|UniProtKB:O70174}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:O70174}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 239..263; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 271..288; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 305..326; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 435..453; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins