Agtrap
entrez
298646
canonical
uniprot
Q642A2
canonical
ensembl
ENSRNOG00000008619
resolver
ensembl
ENSRNOG00055022665
resolver
ensembl
ENSRNOG00060028434
resolver
ensembl
ENSRNOG00065010576
resolver
ensp
ENSRNOP00000011747
resolver
ensp
ENSRNOP00055031559
resolver
ensp
ENSRNOP00060041299
resolver
ensp
ENSRNOP00065013111
resolver
enst
ENSRNOT00000011747
resolver
enst
ENSRNOT00055038884
resolver
enst
ENSRNOT00060049513
resolver
enst
ENSRNOT00065017134
resolver
genesymbol
Agtrap
resolver
genesymbol_syn
Atrap
resolver
uniprot_entry
ATRAP_RAT
resolver
amino_acid_sequence
MELPAVNLKVILLVHWLLTTWGCLAFSGSYAWGNFTILALGVWAVAQRDSVDAIGMFLGGLVATIFLDIIYISIFYSSVAVGDTGRFSAGMAIFSLLLKPFSCCLVYHMHRERGGELPLRSDFFGPSQEHSAYQTIDSSDSPADPLASLENKGQAAPRGY
uniprot
proteins
function
FUNCTION: Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. May play a role of negative regulator in cardiomyocyte hypertrophy induced by angiotensin II through an inhibition of p38 mitogen-activated protein kinase pathway. Attenuates type-1 angiotensin II receptor growth promoting effect and angiotensin II-induced phosphorylation of protein kinase AKT and of STAT3. {ECO:0000269|PubMed:11162453}.
uniprot
proteins
mass_dalton
17398
uniprot
proteins
pubmed
11162453
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
160
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..30; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 54..74; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 87..107; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins