NPR1
entrez
4881
canonical
uniprot
P16066
canonical
ensembl
ENSG00000169418
resolver
ensp
ENSP00000357669
resolver
ensp
ENSP00000578845
resolver
ensp
ENSP00000578846
resolver
ensp
ENSP00000578848
resolver
ensp
ENSP00000726347
resolver
enst
ENST00000368680
resolver
enst
ENST00000908786
resolver
enst
ENST00000908787
resolver
genesymbol
NPR1
resolver
genesymbol_syn
ANPRA
resolver
hgnc
HGNC:7943
resolver
uniprot
A0A140VJE6
resolver
uniprot
B0ZBF0
resolver
uniprot
Q5SR08
resolver
uniprot
Q6P4Q3
resolver
uniprot_entry
A0A140VJE6_HUMAN
resolver
uniprot_entry
ANPRA_HUMAN
resolver
uniprot_sec
B0ZBF0
resolver
uniprot_sec
Q5SR08
resolver
uniprot_sec
Q6P4Q3
resolver
amino_acid_sequence
MPGPRRPAGSRLRLLLLLLLPPLLLLLRGSHAGNLTVAVVLPLANTSYPWSWARVGPAVELALAQVKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDLKWEHNPAVFLGPGCVYAAAPVGRFTAHWRVPLLTAGAPALGFGVKDEYALTTRAGPSYAKLGDFVAALHRRLGWERQALMLYAYRPGDEEHCFFLVEGLFMRVRDRLNITVDHLEFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAFRTLMLLALEAGLCGEDYVFFHLDIFGQSLQGGQGPAPRRPWERGDGQDVSARQAFQAAKIITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGTVTDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVAVSGRKLNWPLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGILIVSFFIYRKMQLEKELASELWRVRWEDVEPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVNRKRIELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDLDPEQGHTVYAKKLWTAPELLRMASPPVRGSQAGDVYSFGIILQEIALRSGVFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGLLMQRCWAEDPQERPPFQQIRLTLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGERGSSTRG
uniprot
proteins
ec_number
4.6.1.2
uniprot
proteins
function
FUNCTION: Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis (PubMed:39543315). Plays an essential role in the regulation of endothelial cell senescence and vascular aging (PubMed:36016499). Upon activation by ANP or BNP, stimulates the production of cyclic guanosine monophosphate (cGMP) that promotes vascular tone and volume homeostasis by activation of protein kinase cGMP-dependent 1/PRKG1 and subsequently PRKAA1, thereby controlling blood pressure and maintaining cardiovascular homeostasis (PubMed:36016499). {ECO:0000269|PubMed:1672777, ECO:0000269|PubMed:36016499, ECO:0000269|PubMed:39543315}.
uniprot
proteins
mass_dalton
118919
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of the protein kinase-like domain is required for full activation by ANP. {ECO:0000250}.
uniprot
proteins
protein_family
Adenylyl cyclase class-4/guanylyl cyclase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1660465
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
1672777
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
20977274
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2569967
uniprot
proteins
pubmed
36016499
uniprot
proteins
pubmed
39543315
uniprot
proteins
pubmed
7954658
uniprot
proteins
pubmed
9618281
uniprot
proteins
sequence_length
1061
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 474..494; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins