Slc7a8
entrez
50934
canonical
uniprot
Q9QXW9
canonical
ensembl
ENSMUSG00000022180
resolver
ensp
ENSMUSP00000022787
resolver
enst
ENSMUST00000022787
resolver
genesymbol
Slc7a8
resolver
genesymbol_syn
Lat2
resolver
uniprot_entry
LAT2_MOUSE
resolver
amino_acid_sequence
MEKGARQRNNTAKNHPGSDTSPEAEASSGGGGVALKKEIGLVSACGIIVGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGIITAVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEFFWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANIAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCLSTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPIKVSLLFPIIYLLFWAFLLIFSLWSEPVVCGIGLAIMLTGVPVYFLGVYWQHKPKCFNDFIKSLTLVSQKMCVVVYPQEGNSGAEETTDDLEEQHKPIFKPTPVKDPDSEEQP
uniprot
proteins
function
FUNCTION: Associates with SLC3A2 to form a functional heterodimeric complex that translocates small and large neutral amino acids with broad specificity and a stoichiometry of 1:1 (PubMed:10574970). Functions as amino acid antiporter mediating the influx of extracellular essential amino acids mainly in exchange with the efflux of highly concentrated intracellular amino acids. Has relatively symmetrical selectivities but strongly asymmetrical substrate affinities at both the intracellular and extracellular sides of the transporter. This asymmetry allows SLC7A8 to regulate intracellular amino acid pools (mM concentrations) by exchange with external amino acids (uM concentration range), equilibrating the relative concentrations of different amino acids across the plasma membrane instead of mediating their net uptake. May play an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane (By similarity). Imports the thyroid hormone diiodothyronine (T2) and to a smaller extent triiodothyronine (T3) but not rT 3 or thyroxine (T4) (PubMed:26601072, PubMed:28108384). Mediates the uptake of L-DOPA (By similarity). May participate in auditory function (PubMed:29355479). Mediates the uptake of leucine, 3-iodo-L-tyrosine (MIT) and 3,5-diiodo-L-tyrosine (DIT) (By similarity). {ECO:0000250|UniProtKB:Q9UHI5, ECO:0000250|UniProtKB:Q9WVR6, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:26601072, ECO:0000269|PubMed:28108384, ECO:0000269|PubMed:29355479}.
uniprot
proteins
mass_dalton
57873
uniprot
proteins
mutagenesis
MUTAGEN 130; /note="Y->A: Increases T2 import. Increases T3 and enables T4 import. Does not affect L-leucine and L-phenylalanine uptake."; /evidence="ECO:0000269|PubMed:28108384"; MUTAGEN 133; /note="N->S: Increases T2 import. Does not affect T3 import. Does not affect L-leucine and L-phenylalanine uptake. Increases the export of both L-leucine and L-phenylalanine."; /evidence="ECO:0000269|PubMed:28108384"; MUTAGEN 242; /note="F->W: Increases T2 import. Does not affect T3 import. Does not affect L-leucine and L-phenylalanine uptake."; /evidence="ECO:0000269|PubMed:28108384
uniprot
proteins
protein_family
Amino acid-polyamine-organocation (APC) superfamily
uniprot
proteins
protein_family
L-type amino acid transporter (LAT) (TC 2.A.3.8) family
uniprot
proteins
pubmed
10574970
uniprot
proteins
pubmed
10610726
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21726201
uniprot
proteins
pubmed
26601072
uniprot
proteins
pubmed
28108384
uniprot
proteins
pubmed
29355479
uniprot
proteins
pubmed
31231240
uniprot
proteins
sequence_length
531
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28108384, ECO:0000269|PubMed:29355479, ECO:0000269|PubMed:31231240}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UHI5}. Basolateral cell membrane {ECO:0000269|PubMed:10574970}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9UHI5}. Note=When coexpressed with SLC3A2/4F2hc, is localized to the plasma membrane. Colocalized with SLC3A2/4F2hc at the basolateral membrane of kidney cortex proximal tubules and small intestine epithelia of the villi. {ECO:0000250|UniProtKB:Q9UHI5}.
uniprot
proteins
transmembrane_region
TRANSMEM 44..64; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q9UHI5"; TRANSMEM 73..94; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q9UHI5"; TRANSMEM 116..148; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q9UHI5"; TRANSMEM 157..177; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q9UHI5"; TRANSMEM 181..209; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q9UHI5"; TRANSMEM 230..251; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q9UHI5"; TRANSMEM 265..286; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q9UHI5"; TRANSMEM 312..337; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q9UHI5"; TRANSMEM 364..381; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q9UHI5"; TRANSMEM 386..407; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q9UHI5"; TRANSMEM 423..445; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q9UHI5"; TRANSMEM 446..465; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:Q9UHI5
uniprot
proteins