Aldh2
entrez
29539
canonical
uniprot
P11884
canonical
ensembl
ENSRNOG00000073701
resolver
ensp
ENSRNOP00000001816
resolver
enst
ENSRNOT00000001816
resolver
genesymbol
Aldh2
resolver
uniprot
F1LN88
resolver
uniprot
Q6Q288
resolver
uniprot
Q6Q289
resolver
uniprot
Q6Q290
resolver
uniprot
Q8K3V8
resolver
uniprot
Q91ZD7
resolver
uniprot_entry
ALDH2_RAT
resolver
uniprot_entry
F1LN88_RAT
resolver
uniprot_sec
Q6Q288
resolver
uniprot_sec
Q6Q289
resolver
uniprot_sec
Q6Q290
resolver
uniprot_sec
Q8K3V8
resolver
uniprot_sec
Q91ZD7
resolver
amino_acid_sequence
MLRAALSTARRGPRLSRLLSAAATSAVPAPNQQPEVFCNQIFINNEWHDAVSKKTFPTVNPSTGEVICQVAEGNKEDVDKAVKAAQAAFQLGSPWRRMDASDRGRLLYRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEDVDKVAFTGSTEVGHLIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQEDVYDEFVERSVARAKSRVVGNPFDSRTEQGPQVDETQFKKILGYIKSGQQEGAKLLCGGGAAADRGYFIQPTVFGDVKDGMTIAKEEIFGPVMQILKFKTIEEVVGRANNSKYGLAAAVFTKDLDKANYLSQALQAGTVWINCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS
uniprot
proteins
ec_number
1.2.1.19
uniprot
proteins
ec_number
1.2.1.24
uniprot
proteins
ec_number
1.2.1.3
uniprot
proteins
ec_number
1.2.1.36
uniprot
proteins
ec_number
1.2.1.46
uniprot
proteins
ec_number
1.7.1.-
uniprot
proteins
function
FUNCTION: Mitochondrial aldehyde dehydrogenase with broad substrate specificity which participates in the detoxification of ethanol-derived acetaldehyde and endogenous aldehydes, including those arising from lipid peroxidation (PubMed:1898068). The reaction mechanism involves a nucleophilic attack on the aldehyde substrate, resulting in formation of a thiohemiacetal intermediate. Subsequent hydride transfer to NAD+, yields a thioester intermediate which is hydrolyzed to the carboxylic acid product through activation of a water molecule by the catalytic glutamate. In vivo, ALDH2 is required for the clearance of formaldehyde, a cytotoxic and carcinogenic endogenous metabolite that induces DNA damage. It also catalyzes the oxidation of 3,4-dihydroxyphenylacetaldehyde (DOPAL), a reactive intermediate of dopamine catabolism, to 3,4-dihydroxyphenylacetate (DOPAC) (By similarity). ALDH2 may also catalyze the oxidation of 4-aminobutanal (gamma-aminobutyraldehyde) to 4-aminobutanoate (GABA), representing an alternative route for GABA biosynthesis from polyamine catabolism (By similarity). In vitro, ALDH2 catalyzes the oxidation of acrolein, malondialdehyde, and 4-hydroxynonenal (4-HNE). It also exhibits esterase activity that is enhanced by NAD+ but does not require it, although the physiological relevance of this activity remains unclear (By similarity). {ECO:0000250|UniProtKB:P05091, ECO:0000250|UniProtKB:P20000, ECO:0000269|PubMed:1898068}.; FUNCTION: Also denitrates nitroglycerin, generating nitric oxide (NO) by a mechanism that remains incompletely understood. {ECO:0000250|UniProtKB:P05091}.
uniprot
proteins
mass_dalton
56488
uniprot
proteins
pathway_participation
PATHWAY: Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2. {ECO:0000305|PubMed:1898068}.
uniprot
proteins
post_translational_modification
PTM: In response to mitochondrial stress, the precursor protein is ubiquitinated by the SIFI complex in the cytoplasm before mitochondrial import, leading to its degradation. {ECO:0000250|UniProtKB:P05091}.
uniprot
proteins
protein_family
Aldehyde dehydrogenase family
uniprot
proteins
pubmed
10721992
uniprot
proteins
pubmed
12893989
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1699808
uniprot
proteins
pubmed
1898068
uniprot
proteins
pubmed
2540003
uniprot
proteins
pubmed
3342060
uniprot
proteins
sequence_length
519
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305|PubMed:1898068}.
uniprot
proteins