Tpp1
entrez
12751
canonical
uniprot
O89023
canonical
ensembl
ENSMUSG00000030894
resolver
ensp
ENSMUSP00000033184
resolver
enst
ENSMUST00000033184
resolver
genesymbol
Tpp1
resolver
genesymbol_syn
Cln2
resolver
uniprot
Q543Q8
resolver
uniprot
Q9QUS7
resolver
uniprot_entry
TPP1_MOUSE
resolver
uniprot_sec
Q543Q8
resolver
uniprot_sec
Q9QUS7
resolver
amino_acid_sequence
MGLQARLLGLLALVIAGKCTYNPEPDQRWMLPPGWVSLGRVDPEEELSLTFALKQRNLERLSELVQAVSDPSSPQYGKYLTLEDVAELVQPSPLTLLTVQKWLSAAGARNCDSVTTQDFLTCWLSVRQAELLLPGAEFHRYVGGPTKTHVIRSPHPYQLPQALAPHVDFVGGLHRFPPSSPRQRPEPQQVGTVSLHLGVTPSVLRQRYNLTAKDVGSGTTNNSQACAQFLEQYFHNSDLTEFMRLFGGSFTHQASVAKVVGKQGRGRAGIEASLDVEYLMSAGANISTWVYSSPGRHEAQEPFLQWLLLLSNESSLPHVHTVSYGDDEDSLSSIYIQRVNTEFMKAAARGLTLLFASGDTGAGCWSVSGRHKFRPSFPASSPYVTTVGGTSFKNPFLITDEVVDYISGGGFSNVFPRPPYQEEAVAQFLKSSSHLPPSSYFNASGRAYPDVAALSDGYWVVSNMVPIPWVSGTSASTPVFGGILSLINEHRILNGRPPLGFLNPRLYQQHGTGLFDVTHGCHESCLNEEVEGQGFCSGPGWDPVTGWGTPNFPALLKTLLNP
uniprot
proteins
ec_number
3.4.14.9
uniprot
proteins
function
FUNCTION: Lysosomal serine protease with tripeptidyl-peptidase I activity (PubMed:28464005). May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases (By similarity). Requires substrates with an unsubstituted N-terminus (By similarity). {ECO:0000250|UniProtKB:O14773, ECO:0000269|PubMed:28464005}.
uniprot
proteins
mass_dalton
61342
uniprot
proteins
mutagenesis
MUTAGEN 207..562; /note="Missing: Premature lethality from 3 months of age, with no survival beyond 6 months. Progressive defects in motor coordination and balance from age 3 months, accompanied by a twitching phenotype. Marked degeneration of astrocytes in the cerebrum. Significant loss of peptidase activity, leading to accumulation of the TPP1 substrate ATP5MC1 in lysosomes."; /evidence="ECO:0000269|PubMed:28464005
uniprot
proteins
post_translational_modification
PTM: Activated by autocatalytic proteolytical processing upon acidification. N-glycosylation is required for processing and activity (By similarity). {ECO:0000250|UniProtKB:O14773}.
uniprot
proteins
pubmed
10556422
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16170054
uniprot
proteins
pubmed
19941651
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28464005
uniprot
proteins
pubmed
9989590
uniprot
proteins
sequence_length
562
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:19941651}. Melanosome {ECO:0000250|UniProtKB:O14773}.
uniprot
proteins