Actn4
entrez
63836
canonical
uniprot
Q9QXQ0
canonical
ensembl
ENSRNOG00000020433
resolver
ensembl
ENSRNOG00055033301
resolver
ensembl
ENSRNOG00060032369
resolver
ensembl
ENSRNOG00065034058
resolver
ensp
ENSRNOP00000027773
resolver
ensp
ENSRNOP00000100770
resolver
ensp
ENSRNOP00000103109
resolver
ensp
ENSRNOP00000106020
resolver
ensp
ENSRNOP00055047496
resolver
ensp
ENSRNOP00060046503
resolver
ensp
ENSRNOP00065048153
resolver
enst
ENSRNOT00000027773
resolver
enst
ENSRNOT00000136183
resolver
enst
ENSRNOT00000140892
resolver
enst
ENSRNOT00055057604
resolver
enst
ENSRNOT00060056298
resolver
enst
ENSRNOT00065058504
resolver
genesymbol
Actn4
resolver
uniprot
A0ABK0KZH9
resolver
uniprot
A0ABK0LQA6
resolver
uniprot
Q6P786
resolver
uniprot_entry
A0ABK0KZH9_RAT
resolver
uniprot_entry
A0ABK0LQA6_RAT
resolver
uniprot_entry
ACTN4_RAT
resolver
uniprot_sec
Q6P786
resolver
amino_acid_sequence
MVDYHAANQAYQYGPSSGGNGTGGGGGMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYERLASDLLEWIRRTIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNVNTRCQKICDQWDNLGSLTHSRREALEKTEKQLETIDQLHLEYAKRAAPFNNWMESAMEDLQDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPYTSVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANMVGPWIQTKMEEIGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEHLRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHGGALGPEEFKACLISLGYDVENDRQGDAEFNRIMSVVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIASFKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQGPDAAPGALDYKSFSTALYGESDL
uniprot
proteins
function
FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions. May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation. {ECO:0000250|UniProtKB:O43707}.
uniprot
proteins
mass_dalton
104915
uniprot
proteins
protein_family
Alpha-actinin family
uniprot
proteins
pubmed
10673389
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15505042
uniprot
proteins
pubmed
15994232
uniprot
proteins
sequence_length
911
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O43707}. Cytoplasm {ECO:0000250|UniProtKB:O43707}. Cell junction {ECO:0000250|UniProtKB:P57780}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:O43707}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P57780}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Expressed in the perinuclear rim and manchette structure in early elongating spermatids during spermiogenesis (By similarity). {ECO:0000250|UniProtKB:O43707, ECO:0000250|UniProtKB:P57780}.
uniprot
proteins