Chrna2
entrez
170945
canonical
uniprot
P12389
canonical
ensembl
ENSRNOG00000017424
resolver
ensembl
ENSRNOG00055006718
resolver
ensembl
ENSRNOG00060010857
resolver
ensembl
ENSRNOG00065017636
resolver
ensp
ENSRNOP00000023475
resolver
ensp
ENSRNOP00055008560
resolver
ensp
ENSRNOP00060014324
resolver
ensp
ENSRNOP00065023418
resolver
enst
ENSRNOT00055010976
resolver
enst
ENSRNOT00060018389
resolver
enst
ENSRNOT00065029502
resolver
genesymbol
Chrna2
resolver
genesymbol_syn
Acra2
resolver
uniprot
O08952
resolver
uniprot
Q53YK3
resolver
uniprot_entry
ACHA2_RAT
resolver
uniprot_sec
O08952
resolver
uniprot_sec
Q53YK3
resolver
amino_acid_sequence
MTLSHSALQFWTHLYLWCLLLVPAVLTQQGSHTHAEDRLFKHLFGGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWDPAEFGNVTSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFFTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMERTVDLKDYWESGEWAIINATGTYNSKKYDCCAEIYPDVTYYFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHNMPNWVRVALLGRVPRWLMMNRPLPPMELHGSPDLKLSPSYHWLETNMDAGEREETEEEEEEEDENICVCAGLPDSSMGVLYGHGGLHLRAMEPETKTPSQASEILLSPQIQKALEGVHYIADRLRSEDADSSVKEDWKYVAMVVDRIFLWLFIIVCFLGTIGLFLPPFLAGMI
uniprot
proteins
function
FUNCTION: Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators. CHRNA2 forms heteropentameric neuronal acetylcholine receptors with CHRNB2 and CHRNB4 and plays a role in nicotine dependence. {ECO:0000250|UniProtKB:Q15822}.
uniprot
proteins
mass_dalton
58611
uniprot
proteins
protein_family
Acetylcholine receptor (TC 1.A.9.1) subfamily
uniprot
proteins
protein_family
Alpha-2/CHRNA2 sub-subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
2832952
uniprot
proteins
sequence_length
511
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Synaptic cell membrane {ECO:0000250|UniProtKB:Q15822}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q15822}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 242..266; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 274..292; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 308..329; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 485..503; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins