CDX2
entrez
1045
canonical
uniprot
Q99626
canonical
ensembl
ENSG00000165556
resolver
ensp
ENSP00000370408
resolver
ensp
ENSP00000561230
resolver
ensp
ENSP00000617430
resolver
ensp
ENSP00000715698
resolver
ensp
ENSP00000715699
resolver
enst
ENST00000381020
resolver
enst
ENST00000947371
resolver
genesymbol
CDX2
resolver
genesymbol_syn
CDX3
resolver
hgnc
HGNC:1806
resolver
uniprot
O00503
resolver
uniprot
Q5VTU7
resolver
uniprot
Q969L8
resolver
uniprot
Q9UD92
resolver
uniprot_entry
CDX2_HUMAN
resolver
uniprot_sec
O00503
resolver
uniprot_sec
Q5VTU7
resolver
uniprot_sec
Q969L8
resolver
uniprot_sec
Q9UD92
resolver
amino_acid_sequence
MYVSYLLDKDVSMYPSSVRHSGGLNLAPQNFVSPPQYPDYGGYHVAAAAAAAANLDSAQSPGPSWPAAYGAPLREDWNGYAPGGAAAAANAVAHGLNGGSPAAAMGYSSPADYHPHHHPHHHPHHPAAAPSCASGLLQTLNPGPPGPAATAAAEQLSPGGQRRNLCEWMRKPAQQSLGSQVKTRTKDKYRVVYTDHQRLELEKEFHYSRYITIRRKAELAATLGLSERQVKIWFQNRRAKERKINKKKLQQQQQQQPPQPPPPPPQPPQPQPGPLRSVPEPLSPVSSLQASVPGSVPGVLGPTGGVLNPTVTQ
uniprot
proteins
function
FUNCTION: Transcription factor which regulates the transcription of multiple genes expressed in the intestinal epithelium (By similarity). Binds to the promoter of the intestinal sucrase-isomaltase SI and activates SI transcription (By similarity). Binds to the DNA sequence 5'-ATAAAAACTTAT-3' in the promoter region of VDR and activates VDR transcription (By similarity). Binds to and activates transcription of LPH (By similarity). Activates transcription of CLDN2 and intestinal mucin MUC2 (By similarity). Binds to the 5'-AATTTTTTACAACACCT-3' DNA sequence in the promoter region of CA1 and activates CA1 transcription (By similarity). Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Binds preferentially to methylated DNA (PubMed:28473536). {ECO:0000250|UniProtKB:P43241, ECO:0000250|UniProtKB:Q04649, ECO:0000269|PubMed:28473536}.
uniprot
proteins
mass_dalton
33520
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, leading to its degradation by the proteasome. {ECO:0000250|UniProtKB:P43241}.; PTM: Phosphorylation at Ser-60 reduces transactivation capacity. Phosphorylation at Ser-283 reduces transactivation capacity and also increases ubiquitin-dependent proteasome degradation. {ECO:0000250|UniProtKB:P43241}.
uniprot
proteins
protein_family
Caudal homeobox family
uniprot
proteins
pubmed
11161380
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
28473536
uniprot
proteins
pubmed
8105782
uniprot
proteins
pubmed
9036867
uniprot
proteins
pubmed
9459001
uniprot
proteins
pubmed
9933478
uniprot
proteins
sequence_length
313
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P43241}.
uniprot
proteins