KCNG4
entrez
93107
canonical
uniprot
Q8TDN1
canonical
ensembl
ENSG00000168418
resolver
ensp
ENSP00000312129
resolver
genesymbol
KCNG4
resolver
genesymbol_syn
KCNG3
resolver
hgnc
HGNC:19697
resolver
uniprot
Q32MC1
resolver
uniprot
Q547S7
resolver
uniprot
Q96H24
resolver
uniprot_entry
KCNG4_HUMAN
resolver
uniprot_entry
Q32MC1_HUMAN
resolver
uniprot_entry
Q547S7_HUMAN
resolver
uniprot_sec
Q96H24
resolver
amino_acid_sequence
MPMPSRDGGLHPRHHHYGSHSPWSQLLSSPMETPSIKGLYYRRVRKVGALDASPVDLKKEILINVGGRRYLLPWSTLDRFPLSRLSKLRLCRSYEEIVQLCDDYDEDSQEFFFDRSPSAFGVIVSFLAAGKLVLLQEMCALSFQEELAYWGIEEAHLERCCLRKLLRKLEELEELAKLHREDVLRQQRETRRPASHSSRWGLCMNRLREMVENPQSGLPGKVFACLSILFVATTAVSLCVSTMPDLRAEEDQGECSRKCYYIFIVETICVAWFSLEFCLRFVQAQDKCQFFQGPLNIIDILAISPYYVSLAVSEEPPEDGERPSGSSYLEKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTVRRCTREFGLLLLFLAVAITLFSPLVYVAEKESGRVLEFTSIPASYWWAIISMTTVGYGDMVPRSVPGQMVALSSILSGILIMAFPATSIFHTFSHSYLELKKEQEQLQARLRHLQNTGPASECELLDPHVASEHELMNDVNDLILEGPALPIMHM
uniprot
proteins
function
FUNCTION: Regulatory subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1, modulates the kinetics parameters of the heterotetrameric channel namely the time course of activation, deactivation and inactivation and on the voltage-dependence of activation (PubMed:12060745, PubMed:19074135). Potassium channel subunit that does not form functional channels by itself (Probable) (PubMed:12060745). Reduces the deactivation rate (PubMed:12060745, PubMed:19074135). Modulates the threshold for activation by shifting by approximately 20 mV in hyperpolarizing direction (PubMed:12060745). Markedly changes the inactivation by shifting the voltage dependence of inactivation by approximately 40 mV in hyperpolarizing direction (PubMed:12060745). Acceleratee activation and enhances the time course of activation (PubMed:12060745). {ECO:0000269|PubMed:12060745, ECO:0000269|PubMed:19074135, ECO:0000305|PubMed:19074135}.
uniprot
proteins
mass_dalton
58979
uniprot
proteins
protein_family
G (TC 1.A.1.2) subfamily
uniprot
proteins
protein_family
Kv6.4/KCNG4 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
12060745
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19074135
uniprot
proteins
sequence_length
519
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19074135}; Multi-pass membrane protein {ECO:0000305}. Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane (PubMed:19074135). Colocalizes with KCNB1 at the plasma membrane (PubMed:19074135). Retains in the endoplasmic reticulum in the absence of KCNB1 (PubMed:19074135). {ECO:0000269|PubMed:19074135}.
uniprot
proteins
transmembrane_region
TRANSMEM 219..240; /note="Helical; Name=Segment S1"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 262..283; /note="Helical; Name=Segment S2"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 295..314; /note="Helical; Name=Segment S3"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 329..353; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 369..390; /note="Helical; Name=Segment S5"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 433..461; /note="Helical; Name=Segment S6"; /evidence="ECO:0000250|UniProtKB:P63142
uniprot
proteins