Oprl1
entrez
18389
canonical
uniprot
P35377
canonical
ensembl
ENSMUSG00000027584
resolver
ensp
ENSMUSP00000071513
resolver
ensp
ENSMUSP00000104394
resolver
ensp
ENSMUSP00000104399
resolver
ensp
ENSMUSP00000159197
resolver
ensp
ENSMUSP00000296393
resolver
enst
ENSMUST00000108763
resolver
enst
ENSMUST00000238942
resolver
genesymbol
Oprl1
resolver
genesymbol_syn
Oor
resolver
genesymbol_syn
Oprl
resolver
uniprot
A0A5F8MPZ9
resolver
uniprot
B0R0C0
resolver
uniprot
Q542U1
resolver
uniprot
Q60645
resolver
uniprot
Q8VI74
resolver
uniprot
Q9QUT5
resolver
uniprot
Q9Z2M8
resolver
uniprot
Q9Z2M9
resolver
uniprot
Q9Z2N0
resolver
uniprot_entry
A0A5F8MPZ9_MOUSE
resolver
uniprot_entry
B0R0C0_MOUSE
resolver
uniprot_entry
OPRX_MOUSE
resolver
uniprot_entry
Q542U1_MOUSE
resolver
uniprot_sec
Q60645
resolver
uniprot_sec
Q8VI74
resolver
uniprot_sec
Q9QUT5
resolver
uniprot_sec
Q9Z2M8
resolver
uniprot_sec
Q9Z2M9
resolver
uniprot_sec
Q9Z2N0
resolver
amino_acid_sequence
MESLFPAPFWEVLYGSHFQGNLSLLNETVPHHLLLNASHSAFLPLGLKVTIVGLYLAVCIGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPAPQDYWGPVFAICIFLFSFIIPVLIISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLVQGLGVQPGSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALHREMQVSDRVRSIAKDVGLGCKTSETVPRPA
uniprot
proteins
function
FUNCTION: G protein-coupled opioid receptor that functions as a receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin. {ECO:0000269|PubMed:12217419, ECO:0000269|PubMed:12814369, ECO:0000269|PubMed:23652222, ECO:0000269|PubMed:7603458, ECO:0000269|PubMed:8794880}.
uniprot
proteins
mass_dalton
40491
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-360 requires GRK3. {ECO:0000250}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12217419
uniprot
proteins
pubmed
12814369
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23652222
uniprot
proteins
pubmed
7603458
uniprot
proteins
pubmed
7797625
uniprot
proteins
pubmed
7802669
uniprot
proteins
pubmed
8794880
uniprot
proteins
pubmed
9155012
uniprot
proteins
pubmed
9755860
uniprot
proteins
sequence_length
367
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cytoplasmic vesicle {ECO:0000250}. Note=Ligand binding leads to receptor internalization into cytoplasmic vesicles, decreasing the amount of available receptor at the cell surface. Internalization requires phosphorylation at Ser-360. Can recycle to the cell membrane (By similarity). {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 46..71; /note="Helical; Name=1"; /evidence="ECO:0000250"; TRANSMEM 85..106; /note="Helical; Name=2"; /evidence="ECO:0000250"; TRANSMEM 122..143; /note="Helical; Name=3"; /evidence="ECO:0000250"; TRANSMEM 163..185; /note="Helical; Name=4"; /evidence="ECO:0000250"; TRANSMEM 209..233; /note="Helical; Name=5"; /evidence="ECO:0000250"; TRANSMEM 262..282; /note="Helical; Name=6"; /evidence="ECO:0000250"; TRANSMEM 298..319; /note="Helical; Name=7"; /evidence="ECO:0000250
uniprot
proteins