Srrm4
entrez
68955
canonical
uniprot
Q8BKA3
canonical
ensembl
ENSMUSG00000063919
resolver
ensp
ENSMUSP00000075488
resolver
genesymbol
Srrm4
resolver
uniprot
J9QHX6
resolver
uniprot
Q8R1S5
resolver
uniprot
Q9CW37
resolver
uniprot_entry
J9QHX6_MOUSE
resolver
uniprot_entry
SRRM4_MOUSE
resolver
uniprot_sec
Q8R1S5
resolver
uniprot_sec
Q9CW37
resolver
amino_acid_sequence
MASLQQGEKQLFEKFWKGTFKAVATPRPESIIVASITARKPMPRTEPQSSLLLPDQDGPSEKLGQHLAPEALGTNSWGREKACRELDPARAHSASQDRDPTPPPSSRGKKKKKKSTRKKRRRSPSYSPSPVKKKKKKSSKKHKRHRSFSKKRRHSSCSPKSKRREEKRHKKQSRSRKSHRHRHHRCPSRSQSSELRSPSCESRHRGRSPEEGRKSRRTHSRRCSKNHCKVSPDARSSHLPSQPLPRLGFLSARGVITGSGSAADLFSKSASPLAATRGRSQEYDSGNDTSSPPSTQTSSARSRGQEKGSPGGDLSKSRDLNCGNTSDSGNSFTTSSPQNKGAVLETVSPACRSRESRGFQSPCLQCAEVKKSSLVPSTARSSPIKECSRSSSYTSTRSSSPSSRSPNPRASPRYTRSRSTSSEKRSYSRSPSYSSKSGKRSPPSRSSRSRRSPSYSRYSPSRERDLKYGEKEPQPRERARRRRRSYSPMRKRRRDSPSHLEARRITSARKRPIPYYRPSPSSSSSLSSASSWYSSSSSSSSSSSRSPSRSYSRSRSPSRSHSSRSQTRSRTRTSRSSSSRSLSLGSRSRSRNRSLSYSSAESYASTRR
uniprot
proteins
function
FUNCTION: Splicing factor specifically required for neural cell differentiation. Acts in conjunction with nPTB/PTBP2 by binding directly to its regulated target transcripts and promotes neural-specific exon inclusion in many genes that function in neural cell differentiation. Required to promote the inclusion of neural-specific exon 10 in nPTB/PTBP2, leading to increased expression of neural-specific nPTB/PTBP2. Also promotes the inclusion of exon 16 in DAAM1 in neuron extracts (PubMed:19737518). Promotes alternative splicing of REST transcripts to produce REST isoform 2 (REST4) with greatly reduced repressive activity, thereby activating expression of REST targets in neural cells (PubMed:21884984). Plays an important role during embryonic development as well as in the proper functioning of the adult nervous system. Regulates alternative splicing events in genes with important neuronal functions (PubMed:25838543). {ECO:0000269|PubMed:19737518, ECO:0000269|PubMed:21884984, ECO:0000269|PubMed:25838543}.
uniprot
proteins
mass_dalton
67860
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000269|PubMed:19737518}.
uniprot
proteins
protein_family
NSR100 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19737518
uniprot
proteins
pubmed
21884984
uniprot
proteins
pubmed
25838543
uniprot
proteins
sequence_length
608
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19737518}.
uniprot
proteins