ATG2A
entrez
23130
canonical
uniprot
Q2TAZ0
canonical
ensembl
ENSG00000110046
resolver
ensp
ENSP00000366475
resolver
ensp
ENSP00000413716
resolver
ensp
ENSP00000549882
resolver
ensp
ENSP00000549883
resolver
genesymbol
ATG2A
resolver
genesymbol_syn
KIAA0404
resolver
hgnc
HGNC:29028
resolver
uniprot
O43154
resolver
uniprot
Q14DM2
resolver
uniprot
Q6ZTV2
resolver
uniprot
Q7Z6K8
resolver
uniprot
Q8IVY5
resolver
uniprot
Q8TAI8
resolver
uniprot
Q96HH7
resolver
uniprot_entry
ATG2A_HUMAN
resolver
uniprot_sec
O43154
resolver
uniprot_sec
Q14DM2
resolver
uniprot_sec
Q6ZTV2
resolver
uniprot_sec
Q7Z6K8
resolver
uniprot_sec
Q8IVY5
resolver
uniprot_sec
Q8TAI8
resolver
uniprot_sec
Q96HH7
resolver
amino_acid_sequence
MSRWLWPWSNCVKERVCRYLLHHYLGHFFQEHLSLDQLSLDLYKGSVALRDIHLEIWSVNEVLESMESPLELVEGFVGSIEVAVPWAALLTDHCTVRVSGLQLTLQPRRGPAPGAADSQSWASCMTTSLQLAQECLRDGLPEPSEPPQPLEGLEMFAQTIETVLRRIKVTFLDTVVRVEHSPGDGERGVAVEVRVQRLEYCDEAVRDPSQAPPVDVHQPPAFLHKLLQLAGVRLHYEELPAQEEPPEPPLQIGSCSGYMELMVKLKQNEAFPGPKLEVAGQLGSLHLLLTPRQLQQLQELLSAVSLTDHEGLADKLNKSRPLGAEDLWLIEQDLNQQLQAGAVAEPLSPDPLTNPLLNLDNTDLFFSMAGLTSSVASALSELSLSDVDLASSVRSDMASRRLSAQAHPAGKMAPNPLLDTMRPDSLLKMTLGGVTLTLLQTSAPSSGPPDLATHFFTEFDATKDGPFGSRDFHHLRPRFQRACPCSHVRLTGTAVQLSWELRTGSRGRRTTSMEVHFGQLEVLECLWPRGTSEPEYTEILTFPGTLGSQASARPCAHLRHTQILRRVPKSRPRRSVACHCHSELALDLANFQADVELGALDRLAALLRLATVPAEPPAGLLTEPLPAMEQQTVFRLSAPRATLRLRFPIADLRPEPDPWAGQAVRAEQLRLELSEPQFRSELSSGPGPPVPTHLELTCSDLHGIYEDGGKPPVPCLRVSKALDPKSTGRKYFLPQVVVTVNPQSSSTQWEVAPEKGEELELSVESPCELREPEPSPFSSKRTMYETEEMVIPGDPEEMRTFQSRTLALSRCSLEVILPSVHIFLPSKEVYESIYNRINNDLLMWEPADLLPTPDPAAQPSGFPGPSGFWHDSFKMCKSAFKLANCFDLTPDSDSDDEDAHFFSVGASGGPQAAAPEAPSLHLQSTFSTLVTVLKGRITALCETKDEGGKRLEAVHGELVLDMEHGTLFSVSQYCGQPGLGYFCLEAEKATLYHRAAVDDYPLPSHLDLPSFAPPAQLAPTIYPSEEGVTERGASGRKGQGRGPHMLSTAVRIHLDPHKNVKEFLVTLRLHKATLRHYMALPEQSWHSQLLEFLDVLDDPVLGYLPPTVITILHTHLFSCSVDYRPLYLPVRVLITAETFTLSSNIIMDTSTFLLRFILDDSALYLSDKCEVETLDLRRDYVCVLDVDLLELVIKTWKGSTEGKLSQPLFELRCSNNVVHVHSCADSCALLVNLLQYVMSTGDLHPPPRPPSPTEIAGQKLSESPASLPSCPPVETALINQRDLADALLDTERSLRELAQPSGGHLPQASPISVYLFPGERSGAPPPSPPVGGPAGSLGSCSEEKEDEREEEGDGDTLDSDEFCILDAPGLGIPPRDGEPVVTQLHPGPIVVRDGYFSRPIGSTDLLRAPAHFPVPSTRVVLREVSLVWHLYGGRDFGPHPGHRARTGLSGPRSSPSRCSGPNRPQNSWRTQGGSGRQHHVLMEIQLSKVSFQHEVYPAEPATGPAAPSQELEERPLSRQVFIVQELEVRDRLASSQINKFLYLHTSERMPRRAHSNMLTIKALHVAPTTNLGGPECCLRVSLMPLRLNVDQDALFFLKDFFTSLVAGINPVVPGETSAEARPETRAQPSSPLEGQAEGVETTGSQEAPGGGHSPSPPDQQPIYFREFRFTSEVPIWLDYHGKHVTMDQVGTFAGLLIGLAQLNCSELKLKRLCCRHGLLGVDKVLGYALNEWLQDIRKNQLPGLLGGVGPMHSVVQLFQGFRDLLWLPIEQYRKDGRLMRGLQRGAASFGSSTASAALELSNRLVQAIQATAETVYDILSPAAPVSRSLQDKRSARRLRRGQQPADLREGVAKAYDTVREGILDTAQTICDVASRGHEQKGLTGAVGGVIRQLPPTVVKPLILATEATSSLLGGMRNQIVPDAHKDHALKWRSDSAQD
uniprot
proteins
function
FUNCTION: Lipid transfer protein involved in autophagosome assembly (PubMed:28561066, PubMed:30952800, PubMed:31271352). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (PubMed:30952800, PubMed:31271352). Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion (PubMed:30952800, PubMed:31271352). Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes (PubMed:31271352). Also regulates lipid droplets morphology and distribution within the cell (PubMed:22219374, PubMed:28561066). {ECO:0000269|PubMed:22219374, ECO:0000269|PubMed:28561066, ECO:0000269|PubMed:30952800, ECO:0000269|PubMed:31271352}.
uniprot
proteins
mass_dalton
212860
uniprot
proteins
mutagenesis
MUTAGEN 54; /note="L->R: In Mutant 1; abolished lipid transfer activity; when associated with R-82, E-101, R-167, E-171, R-193, R-200, E-223, R-285, R-304 and R-328."; /evidence="ECO:0000269|PubMed:30952800"; MUTAGEN 80; /note="I->E: In Mutant 2; abolished lipid transfer activity; when associated with D-103, K-167, R-171, E-193, K-259, E-285 and R-304."; /evidence="ECO:0000269|PubMed:30952800"; MUTAGEN 82; /note="V->R: In Mutant 1; abolished lipid transfer activity; when associated with R-54, E-101, R-167, E-171, R-193, R-200, E-223, R-285, R-304 and R-328."; /evidence="ECO:0000269|PubMed:30952800"; MUTAGEN 101; /note="L->E: In Mutant 1; abolished lipid transfer activity; when associated with R-54, R-82, R-167, E-171, R-193, R-200, E-223, R-285, R-304 and R-328."; /evidence="ECO:0000269|PubMed:30952800"; MUTAGEN 103; /note="L->D: In Mutant 2; abolished lipid transfer activity; when associated with E-80,K-167, R-171, E-193, K-259, E-285 and R-304."; /evidence="ECO:0000269|PubMed:30952800"; MUTAGEN 167; /note="I->K: In Mutant 2; abolished lipid transfer activity; when associated with E-80, D-103, R-171, E-193, K-259, E-285 and R-304."; /evidence="ECO:0000269|PubMed:30952800"; MUTAGEN 167; /note="I->R: In Mutant 1; abolished lipid transfer activity; when associated with R-54, R-82, E-101, E-171, R-193, R-200, E-223, R-285, R-304 and R-328."; /evidence="ECO:0000269|PubMed:30952800"; MUTAGEN 171; /note="F->E: In Mutant 1; abolished lipid transfer activity; when associated with R-54, R-82, E-101, R-167, R-193, R-200, E-223, R-285, R-304 and R-328."; /evidence="ECO:0000269|PubMed:30952800"; MUTAGEN 171; /note="F->R: In Mutant 2; abolished lipid transfer activity; when associated with E-80, D-103, K-167, E-193, K-259, E-285 and R-304."; /evidence="ECO:0000269|PubMed:30952800"; MUTAGEN 193; /note="V->E: In Mutant 2; abolished lipid transfer activity; when associated with E-80, D-103, K-167, R-171, K-259, E-285 and R-304."; /evidence="ECO:0000269|PubMed:30952800"; MUTAGEN 193; /note="V->R: In Mutant 1; abolished lipid transfer activity; when associated with R-54, R-82, E-101, R-167, E-171, R-200, E-223, R-285, R-304 and R-328."; /evidence="ECO:0000269|PubMed:30952800"; MUTAGEN 200; /note="Y->R: In Mutant 1; abolished lipid transfer activity; when associated with R-54, R-82, E-101, R-167, E-171, R-193, E-223, R-285, R-304 and R-328."; /evidence="ECO:0000269|PubMed:30952800"; MUTAGEN 223; /note="L->E: In Mutant 1; abolished lipid transfer activity; when associated with R-54, R-82, E-101, R-167, E-171, R-193, R-200, R-285, R-304 and R-328."; /evidence="ECO:0000269|PubMed:30952800"; MUTAGEN 259; /note="M->K: In Mutant 2; abolished lipid transfer activity; when associated with E-80, D-103, K-167, R-171, E-193, E-285 and R-304."; /evidence="ECO:0000269|PubMed:30952800"; MUTAGEN 285; /note="L->E: In Mutant 2; abolished lipid transfer activity; when associated with E-80, D-103, K-167, R-171, E-193, K-259 and R-304."; /evidence="ECO:0000269|PubMed:30952800"; MUTAGEN 285; /note="L->R: In Mutant 1; abolished lipid transfer activity; when associated with R-54, R-82, E-101, R-167, E-171, R-193, R-200, E-223, R-304 and R-328."; /evidence="ECO:0000269|PubMed:30952800"; MUTAGEN 304; /note="V->R: In Mutant 1; abolished lipid transfer activity; when associated with R-54, R-82, E-101, R-167, E-171, R-193, R-200, E-223, R-285 and R-328. In Mutant 2; abolished lipid transfer activity; when associated with E-80, D-103, K-167, R-171, E-193, K-259 and E-285."; /evidence="ECO:0000269|PubMed:30952800"; MUTAGEN 328; /note="W->R: In Mutant 1; abolished lipid transfer activity; when associated with R-54, R-82, E-101, R-167, E-171, R-193, R-200, E-223, R-285 and R-304."; /evidence="ECO:0000269|PubMed:30952800"; MUTAGEN 1381; /note="V->Q: Decreased interaction with WDR45/WIPI4 and ability to promote autophagy."; /evidence="ECO:0000269|PubMed:32483132"; MUTAGEN 1382; /note="T->Q: Decreased interaction with WDR45/WIPI4 and ability to promote autophagy."; /evidence="ECO:0000269|PubMed:32483132"; MUTAGEN 1389; /note="I->Q: Decreased interaction with WDR45/WIPI4 and ability to promote autophagy."; /evidence="ECO:0000269|PubMed:32483132"; MUTAGEN 1395; /note="Y->A: Decreased interaction with WDR45/WIPI4 and ability to promote autophagy."; /evidence="ECO:0000269|PubMed:32483132"; MUTAGEN 1396; /note="F->A: Decreased interaction with WDR45/WIPI4 and ability to promote autophagy."; /evidence="ECO:0000269|PubMed:32483132
uniprot
proteins
protein_family
ATG2 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21887408
uniprot
proteins
pubmed
22219374
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28561066
uniprot
proteins
pubmed
28820312
uniprot
proteins
pubmed
30952800
uniprot
proteins
pubmed
31271352
uniprot
proteins
pubmed
32483132
uniprot
proteins
pubmed
32610138
uniprot
proteins
pubmed
33106659
uniprot
proteins
pubmed
33850023
uniprot
proteins
pubmed
9455477
uniprot
proteins
sequence_length
1938
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Preautophagosomal structure membrane {ECO:0000269|PubMed:30952800}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q96BY7}. Lipid droplet {ECO:0000250|UniProtKB:Q96BY7}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:30952800}; Peripheral membrane protein {ECO:0000250|UniProtKB:P53855}. Note=Localizes to endoplasmic reticulum-autophagosome contact sites. {ECO:0000269|PubMed:30952800}.
uniprot
proteins