CXCR3
entrez
2833
canonical
uniprot
P49682
canonical
ensembl
ENSG00000186810
resolver
ensp
ENSP00000362795
resolver
ensp
ENSP00000362797
resolver
genesymbol
CXCR3
resolver
genesymbol_syn
GPR9
resolver
hgnc
HGNC:4540
resolver
uniprot
B2R982
resolver
uniprot
O15185
resolver
uniprot
Q7Z710
resolver
uniprot
Q9P2T4
resolver
uniprot
Q9P2T5
resolver
uniprot_entry
CXCR3_HUMAN
resolver
uniprot_sec
B2R982
resolver
uniprot_sec
O15185
resolver
uniprot_sec
Q7Z710
resolver
uniprot_sec
Q9P2T4
resolver
uniprot_sec
Q9P2T5
resolver
amino_acid_sequence
MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL
uniprot
proteins
function
FUNCTION: [Isoform 1]: Receptor for the C-X-C chemokines CXCL9, CXCL10 and CXCL11, and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Probably promotes cell chemotaxis response. Upon activation by PF4, induces activated T-lymphocyte migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling. {ECO:0000269|PubMed:12782716, ECO:0000269|PubMed:18174362, ECO:0000269|PubMed:24469069}.; FUNCTION: [Isoform 2]: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed:12782716). Does not promote cell chemotaxis response. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis. {ECO:0000269|PubMed:12782716}.; FUNCTION: [Isoform 3]: Mediates the activity of CXCL11.
uniprot
proteins
mass_dalton
40660
uniprot
proteins
mutagenesis
MUTAGEN 1..16; /note="Missing: Reduces binding to CXCL10 and CXCL11, and reduces CXCL10- and CXCL11-induced chemotaxis and activation. Does not affect CXCL9-induced chemotaxis and activation."; /evidence="ECO:0000269|PubMed:16847335"; MUTAGEN 4; /note="E->K: Does not affect binding to CXCL9, CXCL10 and CXCL11 or activation."; /evidence="ECO:0000269|PubMed:16847335"; MUTAGEN 21; /note="E->K: Reduces slightly CXCL9-, CXCL10- and CXCL11-induced chemotaxis."; /evidence="ECO:0000269|PubMed:16847335"; MUTAGEN 27..29; /note="YDY->ADA: Abolishes binding to CXCL10 and CXCL11 and CXCL9-, CXCL10- and CXCL11-induced chemotaxis."; /evidence="ECO:0000269|PubMed:16847335"; MUTAGEN 27; /note="Y->F: Reduces sulfation and CXCL9-, CXCL10- and CXCL11-induced chemotaxis. Abolishes binding to CXCL10. Abolishes sulfation, binding to CXCL11, ligand-induced receptor internalization and CXCL9-, CXCL10- and CXCL11-induced chemotaxis; when associated with F-29."; /evidence="ECO:0000269|PubMed:16847335, ECO:0000269|PubMed:19151743"; MUTAGEN 29; /note="Y->F: Reduces sulfation, binding to CXCL10 and CXCL9-, CXCL10- and CXCL11-induced chemotaxis. Abolishes sulfation, binding to CXCL10 and CXCL11 and CXCL9-, CXCL10- and CXCL11-induced chemotaxis; when associated with F-27."; /evidence="ECO:0000269|PubMed:16847335, ECO:0000269|PubMed:19151743"; MUTAGEN 112; /note="D->A: Abolishes binding to CXCL10 and CXCL11. Reduces CXCL9-, CXCL10- and CXCL11-induced chemotaxis."; /evidence="ECO:0000269|PubMed:16847335"; MUTAGEN 112; /note="D->K: Abolishes binding to CXCL10 and CXCL11 and CXCL10- and CXCL11-induced chemotaxis. Reduces CXCL9-induced chemotaxis."; /evidence="ECO:0000269|PubMed:16847335"; MUTAGEN 197; /note="R->A: Abolishes binding to CXCL10 and CXCL11 and CXCL9-, CXCL10- and CXCL11-induced chemotaxis. Reduces ligand-induced receptor internalization."; /evidence="ECO:0000269|PubMed:16847335"; MUTAGEN 212; /note="R->A: Abolishes CXCL10-induced chemotaxis. Reduces CXCL9- and CXCL11-induced chemotaxis. Does not affect binding to CXCL10 and CXCL11."; /evidence="ECO:0000269|PubMed:16847335"; MUTAGEN 216; /note="R->A: Reduces CXCL9-, CXCL10- and CXCL11-induced chemotaxis. Does not affect binding to CXCL10 and CXCL11 or receptor internalization."; /evidence="ECO:0000269|PubMed:16847335"; MUTAGEN 278; /note="D->A: Abolishes binding to CXCL10 and CXCL11 and CXCL11-induced chemotaxis. Reduces CXCL9 and CXCL10-induced chemotaxis."; /evidence="ECO:0000269|PubMed:16847335"; MUTAGEN 278; /note="D->K: Abolishes binding to CXCL10 and CXCL11 and CXCL9-, CXCL10- and CXCL11-induced chemotaxis."; /evidence="ECO:0000269|PubMed:16847335"; MUTAGEN 282; /note="D->A: Reduces binding to CXCL10 and CXCL9-, CXCL10- and CXCL11-induced chemotaxis. Abolishes binding to CXCL11."; /evidence="ECO:0000269|PubMed:16847335"; MUTAGEN 282; /note="D->K: Reduces binding to CXCL10 and CXCL11 and CXCL9-, CXCL10- and CXCL11-induced chemotaxis."; /evidence="ECO:0000269|PubMed:16847335"; MUTAGEN 293; /note="E->A: Reduces binding to CXCL10 and CXCL9- and CXCL11-induced chemotaxis. Abolishes binding to CXCL11 and CXCL10-induced chemotaxis."; /evidence="ECO:0000269|PubMed:16847335"; MUTAGEN 293; /note="E->K: Abolishes binding to CXCL10 and CXCL11 and CXCL9-, CXCL10- and CXCL11-induced chemotaxis."; /evidence="ECO:0000269|PubMed:16847335
uniprot
proteins
post_translational_modification
PTM: Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding and subsequent signal transduction induction. {ECO:0000269|PubMed:16847335, ECO:0000269|PubMed:19151743}.; PTM: N-glycosylated.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10201891
uniprot
proteins
pubmed
11196695
uniprot
proteins
pubmed
12782716
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15528361
uniprot
proteins
pubmed
16847335
uniprot
proteins
pubmed
18174362
uniprot
proteins
pubmed
18291705
uniprot
proteins
pubmed
19151743
uniprot
proteins
pubmed
20855888
uniprot
proteins
pubmed
23121557
uniprot
proteins
pubmed
24469069
uniprot
proteins
pubmed
8666380
uniprot
proteins
pubmed
9064356
uniprot
proteins
pubmed
9625760
uniprot
proteins
sequence_length
368
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:12782716}; Multi-pass membrane protein {ECO:0000269|PubMed:12782716}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:12782716}; Multi-pass membrane protein {ECO:0000269|PubMed:12782716}.
uniprot
proteins
transmembrane_region
TRANSMEM 54..80; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 90..110; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 126..147; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 170..189; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 213..233; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 256..277; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 299..321; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins