Clcn7
entrez
26373
canonical
uniprot
O70496
canonical
ensembl
ENSMUSG00000036636
resolver
ensp
ENSMUSP00000035964
resolver
ensp
ENSMUSP00000124194
resolver
enst
ENSMUST00000040729
resolver
enst
ENSMUST00000160961
resolver
genesymbol
Clcn7
resolver
genesymbol_syn
Clc7
resolver
uniprot
E9PYL4
resolver
uniprot
Q6RUT9
resolver
uniprot_entry
CLCN7_MOUSE
resolver
uniprot_entry
E9PYL4_MOUSE
resolver
uniprot_entry
Q6RUT9_MOUSE
resolver
amino_acid_sequence
MANVSKKVSWSGRDRDDEEGAPLLRRTGQPDEETPLLNGAGPGARQSHSALFRIGQMNNVELDDELLDPEVDPPHTFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKDNIDKFTEKGGLSFSLLLWATLNSAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGILGAVFNALNYWLTMFRIRYIHRPCLQVIEAMLVAAVTATVAFVLIYSSRDCQPLQGSSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPMTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISLSYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGIIVDVLSDTASNHNGFPVVEDVGDTQPARLQGLILRSQLIVLLKHKVFVERSNMGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNHNQVVGLVTRKDLARYRLGKGGLEELSLAQT
uniprot
proteins
function
FUNCTION: Slowly voltage-gated channel mediating the exchange of chloride ions against protons (PubMed:16525474, PubMed:19661288). Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (PubMed:16525474, PubMed:19661288). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). {ECO:0000250|UniProtKB:P35523, ECO:0000269|PubMed:16525474, ECO:0000269|PubMed:19661288}.
uniprot
proteins
mass_dalton
88713
uniprot
proteins
mutagenesis
MUTAGEN 713; /note="Y->C: Increased cytoplasmic vacuole size. Knockin mice develop albinism and lysosomal-storage disease."; /evidence="ECO:0000269|PubMed:31155284
uniprot
proteins
protein_family
Chloride channel (TC 2.A.49) family
uniprot
proteins
protein_family
ClC-7/CLCN7 subfamily
uniprot
proteins
pubmed
11207362
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16525474
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19661288
uniprot
proteins
pubmed
31155284
uniprot
proteins
sequence_length
803
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:16525474, ECO:0000269|PubMed:31155284}; Multi-pass membrane protein {ECO:0000269|PubMed:16525474}.
uniprot
proteins
transmembrane_region
TRANSMEM 125..157; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 172..195; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 221..239; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 245..262; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 320..339; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 373..403; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 408..430; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 485..505; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 510..533; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 577..595; /note="Helical"; /evidence="ECO:0000250
uniprot
proteins