Icam4
entrez
78369
canonical
uniprot
Q9ERM2
canonical
ensembl
ENSMUSG00000001014
resolver
ensp
ENSMUSP00000001040
resolver
ensp
ENSMUSP00000151013
resolver
genesymbol
Icam4
resolver
uniprot
Q14AB0
resolver
uniprot
Q8K4L7
resolver
uniprot
Q9CU00
resolver
uniprot_entry
ICAM4_MOUSE
resolver
uniprot_entry
Q14AB0_MOUSE
resolver
uniprot_sec
Q8K4L7
resolver
uniprot_sec
Q9CU00
resolver
amino_acid_sequence
MESALLLPSLLLVAAYPRGGSPQQEWMQSPPAPSVTSAPFWVRLNPELEAVPPGGSAWLNCSHNCPLPVHSSLRTQLRQGKIVNGSGWVSYQLLDVRAWNSKVRCVVTCAGETREATARITAYKRPRSVILEPPVLVGHKYTLRCYVTHVFPVGFLVVSLRRGGRVIYHESLERFTGSDLANVTLTYVMRAGLNDLWQPLTCHARLNLDGLVVRSSSAPVMLTVLALSPASIALASTSIATLVGILLAVGAVYVRKYLAVQT
uniprot
proteins
function
FUNCTION: Functions as a receptor ligand for the monocyte/macrophage-specific ITGAX:ITGB2 integrin complex and mediates erythrophagocytosis. Receptor ligand of the platelet-specific ITGA2B:ITGB3 integrin complex involved in heterotypic cell-cell adhesion between erythrocytes and activated platelets (By similarity). In vitro, is also a receptor ligand of multiple integrin receptors complexes such ITGAL:ITGB2, ITGAM:ITGB2, ITGA5:ITGB1, ITGA5:ITGB3 and ITGA5:ITGB5 integrin complexes (PubMed:12406883). {ECO:0000250|UniProtKB:Q14773, ECO:0000269|PubMed:12406883}.
uniprot
proteins
mass_dalton
28495
uniprot
proteins
post_translational_modification
PTM: N- and O-glycosylated. {ECO:0000250|UniProtKB:Q14773}.
uniprot
proteins
protein_family
ICAM family
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
12406883
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
262
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:12406883}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:12406883}.
uniprot
proteins
transmembrane_region
TRANSMEM 232..252; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins