Prkab1
entrez
83803
canonical
uniprot
P80386
canonical
ensembl
ENSRNOG00000001142
resolver
ensembl
ENSRNOG00055002209
resolver
ensembl
ENSRNOG00060006496
resolver
ensembl
ENSRNOG00065002107
resolver
ensembl
ENSRNOG00065005719
resolver
ensp
ENSRNOP00000001508
resolver
ensp
ENSRNOP00000101213
resolver
ensp
ENSRNOP00055002613
resolver
ensp
ENSRNOP00060007895
resolver
ensp
ENSRNOP00065001907
resolver
ensp
ENSRNOP00065006028
resolver
enst
ENSRNOT00000001508
resolver
enst
ENSRNOT00000134208
resolver
enst
ENSRNOT00055003507
resolver
enst
ENSRNOT00060010651
resolver
enst
ENSRNOT00065002773
resolver
enst
ENSRNOT00065008546
resolver
genesymbol
Prkab1
resolver
uniprot
A0ABK0L9F1
resolver
uniprot
Q63048
resolver
uniprot_entry
A0ABK0L9F1_RAT
resolver
uniprot_entry
AAKB1_RAT
resolver
uniprot_sec
Q63048
resolver
amino_acid_sequence
MGNTSSERAALERQAGHKTPRRDSSGGTKDGDRPKILMDSPEDADIFHTEEMKAPEKEEFLAWQHDLEVNEKAPAQARPTVFRWTGGGKEVYLSGSFNNWSKLPLTRSQNNFVAILDLPEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKTDFEVFDALMVDSQKCSDVSELSSSPPGPYHQEPYISKPEERFKAPPILPPHLLQVILNKDTGISCDPALLPEPNHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI
uniprot
proteins
function
FUNCTION: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
uniprot
proteins
mass_dalton
30394
uniprot
proteins
mutagenesis
MUTAGEN 100; /note="W->G: Abolishes glycogen-binding."; /evidence="ECO:0000269|PubMed:16216577"; MUTAGEN 100; /note="W->L: Partially inhibits glycogen-binding."; /evidence="ECO:0000269|PubMed:16216577"; MUTAGEN 126; /note="K->Q: Abolishes glycogen-binding."; /evidence="ECO:0000269|PubMed:16216577"; MUTAGEN 146; /note="L->A: Significantly reduces glycogen-binding."; /evidence="ECO:0000269|PubMed:16216577"; MUTAGEN 150; /note="N->K: Abolishes glycogen-binding."; /evidence="ECO:0000269|PubMed:16216577"; MUTAGEN 150; /note="N->Q: Significantly reduces glycogen-binding."; /evidence="ECO:0000269|PubMed:16216577
uniprot
proteins
post_translational_modification
PTM: Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK. {ECO:0000269|PubMed:11171104, ECO:0000269|PubMed:12764152, ECO:0000269|PubMed:21460634, ECO:0000269|PubMed:9305909}.
uniprot
proteins
protein_family
5'-AMP-activated protein kinase beta subunit family
uniprot
proteins
pubmed
11171104
uniprot
proteins
pubmed
12764152
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16216577
uniprot
proteins
pubmed
21460634
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7961907
uniprot
proteins
pubmed
8621499
uniprot
proteins
pubmed
8626596
uniprot
proteins
pubmed
9305909
uniprot
proteins
sequence_length
270
uniprot
proteins