GPR61
entrez
83873
canonical
uniprot
Q9BZJ8
canonical
ensembl
ENSG00000156097
resolver
ensp
ENSP00000385422
resolver
ensp
ENSP00000432456
resolver
ensp
ENSP00000433661
resolver
ensp
ENSP00000484035
resolver
ensp
ENSP00000484797
resolver
enst
ENST00000404129
resolver
enst
ENST00000469383
resolver
enst
ENST00000527748
resolver
enst
ENST00000616874
resolver
enst
ENST00000618721
resolver
genesymbol
GPR61
resolver
genesymbol_syn
BALGR
resolver
genesymbol_syn
GPCR3
resolver
hgnc
HGNC:13300
resolver
uniprot
A8K1W2
resolver
uniprot
G4XH66
resolver
uniprot
Q6NWS0
resolver
uniprot
Q8TDV4
resolver
uniprot
Q96PR4
resolver
uniprot_entry
G4XH66_HUMAN
resolver
uniprot_entry
GPR61_HUMAN
resolver
uniprot_sec
A8K1W2
resolver
uniprot_sec
Q6NWS0
resolver
uniprot_sec
Q8TDV4
resolver
uniprot_sec
Q96PR4
resolver
amino_acid_sequence
MESSPIPQSSGNSSTLGRVPQTPGPSTASGVPEVGLRDVASESVALFFMLLLDLTAVAGNAAVMAVIAKTPALRKFVFVFHLCLVDLLAALTLMPLAMLSSSALFDHALFGEVACRLYLFLSVCFVSLAILSVSAINVERYYYVVHPMRYEVRMTLGLVASVLVGVWVKALAMASVPVLGRVSWEEGAPSVPPGCSLQWSHSAYCQLFVVVFAVLYFLLPLLLILVVYCSMFRVARVAAMQHGPLPTWMETPRQRSESLSSRSTMVTSSGAPQTTPHRTFGGGKAAVVLLAVGGQFLLCWLPYFSFHLYVALSAQPISTGQVESVVTWIGYFCFTSNPFFYGCLNRQIRGELSKQFVCFFKPAPEEELRLPSREGSIEENFLQFLQGTGCPSESWVSRPLPSPKQEPPAVDFRIPGQIAEETSEFLEQQLTSDIIMSDSYLRPAASPRLES
uniprot
proteins
function
FUNCTION: Orphan G protein-coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway (PubMed:28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538). May be involved in the regulation of food intake and body weight (By similarity). {ECO:0000250|UniProtKB:Q8C010, ECO:0000269|PubMed:28827538}.
uniprot
proteins
mass_dalton
49292
uniprot
proteins
mutagenesis
MUTAGEN 12; /note="N->S: Does not affect subcellular location."; /evidence="ECO:0000269|PubMed:29226084
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11165367
uniprot
proteins
pubmed
11690637
uniprot
proteins
pubmed
12044878
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
28827538
uniprot
proteins
pubmed
29226084
uniprot
proteins
sequence_length
451
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28827538, ECO:0000269|PubMed:29226084}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:28827538}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with ARRB2/beta-arrestin-2 in the endosome (PubMed:28827538). {ECO:0000269|PubMed:28827538}.
uniprot
proteins
transmembrane_region
TRANSMEM 45..67; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 76..98; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 113..135; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 156..178; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 207..229; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 288..310; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 325..344; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins