MAST3
entrez
23031
canonical
uniprot
O60307
canonical
ensembl
ENSG00000099308
resolver
ensp
ENSP00000262811
resolver
ensp
ENSP00000509890
resolver
ensp
ENSP00000513408
resolver
ensp
ENSP00000513409
resolver
ensp
ENSP00000563474
resolver
ensp
ENSP00000563475
resolver
enst
ENST00000262811
resolver
enst
ENST00000687212
resolver
enst
ENST00000697701
resolver
enst
ENST00000697702
resolver
genesymbol
MAST3
resolver
genesymbol_syn
KIAA0561
resolver
hgnc
HGNC:19036
resolver
uniprot
A0A8I5KST9
resolver
uniprot
A0A8V8TLL8
resolver
uniprot
A0A8V8TMW0
resolver
uniprot
Q7LDZ8
resolver
uniprot
Q9UPI0
resolver
uniprot_entry
A0A8I5KST9_HUMAN
resolver
uniprot_entry
A0A8V8TLL8_HUMAN
resolver
uniprot_entry
A0A8V8TMW0_HUMAN
resolver
uniprot_entry
MAST3_HUMAN
resolver
uniprot_sec
Q7LDZ8
resolver
uniprot_sec
Q9UPI0
resolver
activity_regulation
ACTIVITY REGULATION: Kinase activity with ARPP19 as substrate is down-regulated by PKA-mediated phosphorylation. {ECO:0000269|PubMed:28613156}.
uniprot
proteins
amino_acid_sequence
MDESSLLRRRGLQKELSLPRRGRGCRSGNRKSLVVGTPSPTLSRPLSPLSVPTAGSSPLDSPRNFSAASALNFPFARRADGRRWSLASLPSSGYGTNTPSSTLSSSSSSRERLHQLPFQPTPDELHFLSKHFRSSENVLDEEGGRSPRLRPRSRSLSPGRATGTFDNEIVMMNHVYRERFPKATAQMEGRLQEFLTAYAPGARLALADGVLGFIHHQIVELARDCLAKSGENLVTSRYFLEMQEKLERLLQDAHERSDSEEVSFIVQLVRKLLIIISRPARLLECLEFDPEEFYHLLEAAEGHAREGQGIKTDLPQYIIGQLGLAKDPLEEMVPLSHLEEEQPPAPESPESRALVGQSRRKPCESDFETIKLISNGAYGAVYLVRHRDTRQRFAIKKINKQNLILRNQIQQVFVERDILTFAENPFVVSMFCSFETRRHLCMVMEYVEGGDCATLLKNMGPLPVDMARLYFAETVLALEYLHNYGIVHRDLKPDNLLITSLGHIKLTDFGLSKIGLMSMATNLYEGHIEKDAREFIDKQVCGTPEYIAPEVIFRQGYGKPVDWWAMGVVLYEFLVGCVPFFGDTPEELFGQVVSDEIMWPEGDEALPADAQDLITRLLRQSPLDRLGTGGTHEVKQHPFFLALDWAGLLRHKAEFVPQLEAEDDTSYFDTRSERYRHLGSEDDETNDEESSTEIPQFSSCSHRFSKVYSSSEFLAVQPTPTFAERSFSEDREEGWERSEVDYGRRLSADIRLRSWTSSGSSCQSSSSQPERGPSPSLLNTISLDTMPKFAFSSEDEGVGPGPAGPKRPVFILGEPDPPPAATPVMPKPSSLSADTAALSHARLRSNSIGARHSTPRPLDAGRGRRLGGPRDPAPEKSRASSSGGSGGGSGGRVPKSASVSALSLIITADDGSGGPLMSPLSPRSLSSNPSSRDSSPSRDPSPVCGSLRPPIVIHSSGKKYGFSLRAIRVYMGDSDVYTVHHVVWSVEDGSPAQEAGLRAGDLITHINGESVLGLVHMDVVELLLKSGNKISLRTTALENTSIKVGPARKNVAKGRMARRSKRSRRRETQDRRKSLFKKISKQTSVLHTSRSFSSGLHHSLSSSESLPGSPTHSLSPSPTTPCRSPAPDVPADTTASPPSASPSSSSPASPAAAGHTRPSSLHGLAAKLGPPRPKTGRRKSTSSIPPSPLACPPISAPPPRSPSPLPGHPPAPARSPRLRRGQSADKLGTGERLDGEAGRRTRGPEAELVVMRRLHLSERRDSFKKQEAVQEVSFDEPQEEATGLPTSVPQIAVEGEEAVPVALGPTGRD
uniprot
proteins
disease_involvement
DISEASE: Developmental and epileptic encephalopathy 108 (DEE108) [MIM:620115]: A form of epileptic encephalopathy, a heterogeneous group of early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE108 is an autosomal dominant form characterized by the onset of multiple types of seizures in the first 2 years of life. {ECO:0000269|PubMed:34185323, ECO:0000269|PubMed:35095415}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine kinase that phosphorylates ARPP19 at 'Ser-62', resulting in protein phosphatase 2A (PP2A) inhibition by ARPP19. {ECO:0000269|PubMed:28167675, ECO:0000269|PubMed:28613156}.
uniprot
proteins
mass_dalton
143137
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKA; phosphorylation down-regulates kinase activity. {ECO:0000269|PubMed:28613156}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15951562
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28167675
uniprot
proteins
pubmed
28613156
uniprot
proteins
pubmed
34185323
uniprot
proteins
pubmed
35095415
uniprot
proteins
pubmed
9628581
uniprot
proteins
sequence_length
1309
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q3U214}.
uniprot
proteins