CEMIP
entrez
57214
canonical
uniprot
Q8WUJ3
canonical
ensembl
ENSG00000103888
resolver
ensp
ENSP00000220244
resolver
ensp
ENSP00000348583
resolver
ensp
ENSP00000378177
resolver
genesymbol
CEMIP
resolver
genesymbol_syn
HYBID
resolver
genesymbol_syn
KIAA1199
resolver
hgnc
HGNC:29213
resolver
uniprot
Q6L9J5
resolver
uniprot
Q9H1K5
resolver
uniprot
Q9NPN9
resolver
uniprot
Q9ULM1
resolver
uniprot_entry
CEMIP_HUMAN
resolver
uniprot_sec
Q6L9J5
resolver
uniprot_sec
Q9H1K5
resolver
uniprot_sec
Q9NPN9
resolver
uniprot_sec
Q9ULM1
resolver
activity_regulation
ACTIVITY REGULATION: Activity is up-regulated by histamine. {ECO:0000269|PubMed:23509262}.
uniprot
proteins
amino_acid_sequence
MGAAGRQDFLFKAMLTISWLTLTCFPGATSTVAAGCPDQSPELQPWNPGHDQDHHVHIGQGKTLLLTSSATVYSIHISEGGKLVIKDHDEPIVLRTRHILIDNGGELHAGSALCPFQGNFTIILYGRADEGIQPDPYYGLKYIGVGKGGALELHGQKKLSWTFLNKTLHPGGMAEGGYFFERSWGHRGVIVHVIDPKSGTVIHSDRFDTYRSKKESERLVQYLNAVPDGRILSVAVNDEGSRNLDDMARKAMTKLGSKHFLHLGFRHPWSFLTVKGNPSSSVEDHIEYHGHRGSAAARVFKLFQTEHGEYFNVSLSSEWVQDVEWTEWFDHDKVSQTKGGEKISDLWKAHPGKICNRPIDIQATTMDGVNLSTEVVYKKGQDYRFACYDRGRACRSYRVRFLCGKPVRPKLTVTIDTNVNSTILNLEDNVQSWKPGDTLVIASTDYSMYQAEEFQVLPCRSCAPNQVKVAGKPMYLHIGEEIDGVDMRAEVGLLSRNIIVMGEMEDKCYPYRNHICNFFDFDTFGGHIKFALGFKAAHLEGTELKHMGQQLVGQYPIHFHLAGDVDERGGYDPPTYIRDLSIHHTFSRCVTVHGSNGLLIKDVVGYNSLGHCFFTEDGPEERNTFDHCLGLLVKSGTLLPSDRDSKMCKMITEDSYPGYIPKPRQDCNAVSTFWMANPNNNLINCAAAGSEETGFWFIFHHVPTGPSVGMYSPGYSEHIPLGKFYNNRAHSNYRAGMIIDNGVKTTEASAKDKRPFLSIISARYSPHQDADPLKPREPAIIRHFIAYKNQDHGAWLRGGDVWLDSCRFADNGIGLTLASGGTFPYDDGSKQEIKNSLFVGESGNVGTEMMDNRIWGPGGLDHSGRTLPIGQNFPIRGIQLYDGPINIQNCTFRKFVALEGRHTSALAFRLNNAWQSCPHNNVTGIAFEDVPITSRVFFGEPGPWFNQLDMDGDKTSVFHDVDGSVSEYPGSYLTKNDNWLVRHPDCINVPDWRGAICSGCYAQMYIQAYKTSNLRMKIIKNDFPSHPLYLEGALTRSTHYQQYQPVVTLQKGYTIHWDQTAPAELAIWLINFNKGDWIRVGLCYPRGTTFSILSDVHNRLLKQTSKTGVFVRTLQMDKVEQSYPGRSHYYWDEDSGLLFLKLKAQNEREKFAFCSMKGCERIKIKALIPKNAGVSDCTATAYPKFTERAVVDVPMPKKLFGSQLKTKDHFLEVKMESSKQHFFHLWNDFAYIEVDGKKYPSSEDGIQVVVIDGNQGRVVSHTSFRNSILQGIPWQLFNYVATIPDNSIVLMASKGRYVSRGPWTRVLEKLGADRGLKLKEQMAFVGFKGSFRPIWVTLDTEDHKAKIFQVVPIPVVKKKKL
uniprot
proteins
ec_number
3.2.1.35
uniprot
proteins
function
FUNCTION: Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing. {ECO:0000269|PubMed:23509262, ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:24269685}.
uniprot
proteins
mass_dalton
152998
uniprot
proteins
post_translational_modification
PTM: N-glycosylated; glycosylation is not necessary for HA-binding. {ECO:0000269|PubMed:23936024, ECO:0000269|PubMed:24269685}.
uniprot
proteins
protein_family
CEMIP family
uniprot
proteins
pubmed
10574462
uniprot
proteins
pubmed
11247670
uniprot
proteins
pubmed
12471561
uniprot
proteins
pubmed
14577002
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16157444
uniprot
proteins
pubmed
19434458
uniprot
proteins
pubmed
21772334
uniprot
proteins
pubmed
22970280
uniprot
proteins
pubmed
23509262
uniprot
proteins
pubmed
23936024
uniprot
proteins
pubmed
23990668
uniprot
proteins
pubmed
24269685
uniprot
proteins
sequence_length
1361
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Endoplasmic reticulum. Cell membrane. Membrane, clathrin-coated pit. Secreted. Note=Retained in the endoplasmic reticulum (ER) in a HSPA5/BIP-dependent manner. Colocalized with clathrin heavy chain/CLTC in clathrin-coated vesicles. Strongly detected in the cytoplasm of breast carcinoma cells, whereas poorly detected in adjacent normal epithelial cells, stromal cells, or benign breast tissues. Localized in the nucleus and cytoplasm of colon adenocarcinomas.
uniprot
proteins