DHX33
entrez
56919
canonical
uniprot
Q9H6R0
canonical
ensembl
ENSG00000005100
resolver
ensp
ENSP00000225296
resolver
ensp
ENSP00000458925
resolver
ensp
ENSP00000671665
resolver
genesymbol
DHX33
resolver
genesymbol_syn
DDX33
resolver
hgnc
HGNC:16718
resolver
uniprot
B4DHF9
resolver
uniprot
B4DIS6
resolver
uniprot
Q4G149
resolver
uniprot
Q5CZ73
resolver
uniprot
Q9H5M9
resolver
uniprot_entry
B4DIS6_HUMAN
resolver
uniprot_entry
DHX33_HUMAN
resolver
uniprot_sec
B4DHF9
resolver
uniprot_sec
Q4G149
resolver
uniprot_sec
Q5CZ73
resolver
uniprot_sec
Q9H5M9
resolver
amino_acid_sequence
MPEEAGFPPAKRFRPGSGPPSRAGSFPPGRQVVMLLTAGSGGRGGGGGRRQQPPLAQPSASPYPEAVELQRRSLPIFQARGQLLAQLRNLDNAVLIGETGSGKTTQIPQYLYEGGISRQGIIAVTQPRRVAAISLATRVSDEKRTELGKLVGYTVRFDDVTSEDTRIKFLTDGMLLREAISDSLLRKYSCVILDEAHERTIHTDVLFGVVKAAQKRRKELGKLPLKVIVMSATMDVDLFSQYFNGAPVLYLEGRQHPIQVFYTKQPQNDYLHAALVSVFQIHQEAPSSQDILVFLTGQEEIEAMSKTCRDIAKHLPDGCPAMLVLPLYASLPYAQQLRVFQGAPKGYRKVIISTNIAETSITITGIKYVVDTGMVKAKKYNPDSGLEVLAVQRVSKTQAWQRTGRAGREDSGICYRLYTEDEFEKFDKMTVPEIQRCNLASVMLQLLAMKVPNVLTFDFMSKPSPDHIQAAIAQLDLLGALEHKDDQLTLTPMGRKMAAFPLEPKFAKTILMSPKFHCTEEILTIVSLLSVDSVLHNPPSRREEVQGVRKKFISSEGDHMTLLNIYRTFKNLGGNKDWCKENFVNSKNMTLVAEVRAQLRDICLKMSMPIASSRGDVESVRRCLAHSLFMSTAELQPDGTYATTDTHQPVAIHPSSVLFHCKPACVVYTELLYTNKCYMRDLCVIDAQWLYEAAPEYFRRKLRTARN
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: Implicated in nucleolar organization, ribosome biogenesis, protein synthesis and cytoplasmic dsRNA sensing (By similarity) (PubMed:21930779, PubMed:23871209, PubMed:26100019). Stimulates RNA polymerase I transcription of the 47S precursor rRNA. Associates with ribosomal DNA (rDNA) loci where it is involved in POLR1A recruitment (PubMed:21930779). In the cytoplasm, promotes elongation-competent 80S ribosome assembly at the late stage of mRNA translation initiation (PubMed:26100019). Senses cytosolic dsRNA mediating NLRP3 inflammasome formation in macrophages and type I interferon production in myeloid dendritic cells (PubMed:23871209). Required for NLRP3 activation induced by viral dsRNA and bacterial RNA (PubMed:23871209). In dendritic cells, required for induction of type I interferon production induced by cytoplasmic dsRNA via the activation of MAPK and NF-kappa-B signaling pathways (By similarity). {ECO:0000250|UniProtKB:Q80VY9, ECO:0000269|PubMed:21930779, ECO:0000269|PubMed:23871209, ECO:0000269|PubMed:26100019}.
uniprot
proteins
mass_dalton
78874
uniprot
proteins
mutagenesis
MUTAGEN 103; /note="K->N: No effect on inflammasome activation upon dsRNA-binding."; /evidence="ECO:0000269|PubMed:23871209
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, leading to its degradation by the proteasome. Deubiquitinated by USP36. {ECO:0000250|UniProtKB:Q80VY9}.
uniprot
proteins
protein_family
DEAD box helicase family
uniprot
proteins
protein_family
DEAH subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21930779
uniprot
proteins
pubmed
23871209
uniprot
proteins
pubmed
26100019
uniprot
proteins
sequence_length
707
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:21930779, ECO:0000269|PubMed:26100019}. Nucleus, nucleoplasm {ECO:0000269|PubMed:21930779}. Cytoplasm {ECO:0000269|PubMed:23871209, ECO:0000269|PubMed:26100019}. Nucleus {ECO:0000269|PubMed:23871209}. Inflammasome {ECO:0000269|PubMed:23871209}. Note=Predominantly in the nucleolus. During mitosis, localizes with the nucleolar organizing regions (PubMed:21930779). Upon dsRNA-binding, localizes in the inflammasome (PubMed:23871209). {ECO:0000269|PubMed:21930779, ECO:0000269|PubMed:23871209}.
uniprot
proteins