PAIP1
entrez
10605
canonical
uniprot
Q9H074
canonical
ensembl
ENSG00000172239
resolver
ensp
ENSP00000302768
resolver
ensp
ENSP00000339622
resolver
ensp
ENSP00000387729
resolver
genesymbol
PAIP1
resolver
hgnc
HGNC:16945
resolver
uniprot
A6NKV8
resolver
uniprot
O60455
resolver
uniprot
Q96B61
resolver
uniprot
Q9BS63
resolver
uniprot_entry
PAIP1_HUMAN
resolver
uniprot_sec
A6NKV8
resolver
uniprot_sec
O60455
resolver
uniprot_sec
Q96B61
resolver
uniprot_sec
Q9BS63
resolver
amino_acid_sequence
MSDGFDRAPGAGRGRSRGLGRGGGGPEGGGFPNGAGPAERARHQPPQPKAPGFLQPPPLRQPRTTPPPGAQCEVPASPQRPSRPGALPEQTRPLRAPPSSQDKIPQQNSESAMAKPQVVVAPVLMSKLSVNAPEFYPSGYSSSYTESYEDGCEDYPTLSEYVQDFLNHLTEQPGSFETEIEQFAETLNGCVTTDDALQELVELIYQQATSIPNFSYMGARLCNYLSHHLTISPQSGNFRQLLLQRCRTEYEVKDQAAKGDEVTRKRFHAFVLFLGELYLNLEIKGTNGQVTRADILQVGLRELLNALFSNPMDDNLICAVKLLKLTGSVLEDAWKEKGKMDMEEIIQRIENVVLDANCSRDVKQMLLKLVELRSSNWGRVHATSTYREATPENDPNYFMNEPTFYTSDGVPFTAADPDYQEKYQELLEREDFFPDYEENGTDLSGAGDPYLDDIDDEMDPEIEEAYEKFCLESERKRKQ
uniprot
proteins
function
FUNCTION: Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:9548260}.; FUNCTION: (Microbial infection) Upon interaction with SARS coronavirus SARS-CoV NSP3 protein, plays an important role in viral protein synthesis. {ECO:0000269|PubMed:33876849}.
uniprot
proteins
mass_dalton
53525
uniprot
proteins
pubmed
10970864
uniprot
proteins
pubmed
11051545
uniprot
proteins
pubmed
11172725
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
11997512
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
33876849
uniprot
proteins
pubmed
37316325
uniprot
proteins
pubmed
9548260
uniprot
proteins
sequence_length
479
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
uniprot
proteins