Fam76b
entrez
72826
canonical
uniprot
Q80XP8
canonical
ensembl
ENSMUSG00000037808
resolver
ensp
ENSMUSP00000062642
resolver
ensp
ENSMUSP00000184503
resolver
genesymbol
Fam76b
resolver
uniprot
Q3UMA6
resolver
uniprot
Q80YR1
resolver
uniprot
Q8CI69
resolver
uniprot_entry
FA76B_MOUSE
resolver
uniprot_sec
Q3UMA6
resolver
uniprot_sec
Q80YR1
resolver
uniprot_sec
Q8CI69
resolver
amino_acid_sequence
MAASALYACTKCTQRYPFEELSQGQQLCKECRIAHPIVKCTYCRSEFQQESKTNTICKKCAQNVKQFGTPKPCQYCNIIAAFIGTKCQRCTNSEKKYGAPQTCEQCKQQCAFDRKEEGRRKVDGKLLCWLCTLSYKRVLQKTKEQRKSLGSSHSNSSSSSLTEKDQHHSKHHHHHHHHHHRHSSGHHKVSSLSPEQEQGLWKQSHKSSAAIQNETPKKKPKLESKPSNGDSSSINQSADSGGTDNFVLISQLKEEVMSLKRLLQQRDQTILEKDKKLTELKADFQYQESNLRTKMNSMEKAHKETVEQLQAKNRELLKQVAALSKGKKFDKSGSVLTSP
uniprot
proteins
function
FUNCTION: Negatively regulates the NF-kappa-B-mediated inflammatory pathway by preventing the translocation of HNRNPA2B1 from the nucleus to the cytoplasm. Inhibits the PI3K/Akt/NF-kappa-B pathway-mediated polarization of M1 macrophages by binding to and stabilizing PIK3CD mRNA, resulting in increased levels of PIK3CD protein and increased levels of phosphorylated downstream target AKT which leads to decreased NF-kappa-B signaling. {ECO:0000250|UniProtKB:Q5HYJ3}.
uniprot
proteins
mass_dalton
38556
uniprot
proteins
protein_family
FAM76 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
37643469
uniprot
proteins
sequence_length
339
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q5HYJ3}.
uniprot
proteins