Ehd2
entrez
361512
canonical
uniprot
Q4V8H8
canonical
ensembl
ENSRNOG00000011346
resolver
ensembl
ENSRNOG00055016818
resolver
ensembl
ENSRNOG00060020203
resolver
ensembl
ENSRNOG00065033793
resolver
ensp
ENSRNOP00000017353
resolver
ensp
ENSRNOP00055023014
resolver
ensp
ENSRNOP00060028721
resolver
ensp
ENSRNOP00065047778
resolver
enst
ENSRNOT00000017353
resolver
enst
ENSRNOT00055028576
resolver
enst
ENSRNOT00060034967
resolver
enst
ENSRNOT00065058030
resolver
genesymbol
Ehd2
resolver
uniprot_entry
EHD2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: The very low intrinsic ATPase activity is increased upon interaction with liposomes. {ECO:0000250|UniProtKB:Q8BH64}.
uniprot
proteins
amino_acid_sequence
MFSWLKKGGARGQRSEAIRTVTSSLKELYRTKLLPLEEHYRFGSFHSPALEDADFDGKPMVLVAGQYSTGKTSFIQYLLEQEVPGSRVGPEPTTDCFVAVMHGETEGTVPGNALVVDPEKPFRKLNPFGNTFLNRFMCAQLPNQVLESISIIDTPGILSGAKQRVSRGYDFPAVLRWFAERVDLIILLFDAHKLEISDEFSEAIGALRGHEDKIRVVLNKADMVETQQLMRVYGALMWALGKVVGTPEVLRVYIGSFWSQPLLVPDNRRLFELEEQDLFRDIQGLPRHAALRKLNDLVKRARLVRVHAYIISYLKKEMPSVFGKENKKKQLIFKLPVIFAKIQLEHHISPGDFPDCQKMQELLMAHDFTKFHSLKPKLLEALDEMLTHDIAKLMPLLRQEELESVEAGVQGGAFEGTRMGPFVERGPDEAIEDGEEGSEDDAEWVVTKDKSKYDEIFYNLAPADGKLSGSKAKTWMVGTKLPNSVLGRIWKLSDVDRDGMLDDEEFALASHLIEAKLEGHGLPTNLPRRLVPPSKRRQKGSAE
uniprot
proteins
function
FUNCTION: ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4. Required for fusion of myoblasts to skeletal muscle myotubes. Required for normal translocation of FER1L5 to the plasma membrane. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by constraining caveolae at the cell membrane. {ECO:0000250|UniProtKB:Q8BH64, ECO:0000250|UniProtKB:Q9NZN4}.
uniprot
proteins
mass_dalton
61237
uniprot
proteins
protein_family
Dynamin/Fzo/YdjA family
uniprot
proteins
protein_family
EHD subfamily
uniprot
proteins
protein_family
TRAFAC class dynamin-like GTPase superfamily
uniprot
proteins
pubmed
14676205
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
543
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14676205}; Peripheral membrane protein {ECO:0000269|PubMed:14676205}; Cytoplasmic side {ECO:0000269|PubMed:14676205}. Membrane, caveola {ECO:0000250|UniProtKB:Q8BH64}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8BH64}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8BH64}. Endosome membrane {ECO:0000269|PubMed:14676205}; Peripheral membrane protein {ECO:0000269|PubMed:14676205}; Cytoplasmic side {ECO:0000269|PubMed:14676205}. Cytoplasm, cytosol {ECO:0000269|PubMed:14676205}. Note=Colocalizes with GLUT4 in intracellular tubulovesicular structures that are associated with cortical F-actin (PubMed:14676205). Colocalizes with FER1L5 at plasma membrane in myoblasts and myotubes (By similarity). {ECO:0000250|UniProtKB:Q8BH64, ECO:0000269|PubMed:14676205}.
uniprot
proteins