DSCR1
entrez
1827
canonical
uniprot
P53805
canonical
ensembl
ENSG00000159200
resolver
ensp
ENSP00000320768
resolver
ensp
ENSP00000370524
resolver
ensp
ENSP00000370527
resolver
ensp
ENSP00000382214
resolver
ensp
ENSP00000392438
resolver
ensp
ENSP00000477155
resolver
ensp
ENSP00000477646
resolver
enst
ENST00000381135
resolver
enst
ENST00000492600
resolver
genesymbol
DSCR1
resolver
genesymbol
RCAN1
resolver
genesymbol_syn
ADAPT78
resolver
genesymbol_syn
CSP1
resolver
genesymbol_syn
DSC1
resolver
genesymbol_syn
DSCR1
resolver
hgnc
HGNC:3040
resolver
uniprot
B7Z1F0
resolver
uniprot
D3DSF9
resolver
uniprot
E9PDJ2
resolver
uniprot
O00582
resolver
uniprot
O00583
resolver
uniprot
Q53XT0
resolver
uniprot
Q6FGP2
resolver
uniprot
Q6IBC6
resolver
uniprot
Q6ZMM3
resolver
uniprot
Q7Z555
resolver
uniprot
Q96R03
resolver
uniprot
Q9BU69
resolver
uniprot
Q9UF15
resolver
uniprot
Q9UME4
resolver
uniprot
V9GYW9
resolver
uniprot_entry
B7Z1F0_HUMAN
resolver
uniprot_entry
E9PDJ2_HUMAN
resolver
uniprot_entry
Q6FGP2_HUMAN
resolver
uniprot_entry
Q6ZMM3_HUMAN
resolver
uniprot_entry
RCAN1_HUMAN
resolver
uniprot_entry
V9GYW9_HUMAN
resolver
uniprot_sec
D3DSF9
resolver
uniprot_sec
O00582
resolver
uniprot_sec
O00583
resolver
uniprot_sec
Q53XT0
resolver
uniprot_sec
Q6IBC6
resolver
uniprot_sec
Q7Z555
resolver
uniprot_sec
Q96R03
resolver
uniprot_sec
Q9BU69
resolver
uniprot_sec
Q9UF15
resolver
uniprot_sec
Q9UME4
resolver
amino_acid_sequence
MEDGVAGPQLGAAAEAAEAAEARARPGVTLRPFAPLSGAAEADEGGGDWSFIDCEMEEVDLQDLPSATIACHLDPRVFVDGLCRAKFESLFRTYDKDITFQYFKSFKRVRINFSNPFSAADARLQLHKTEFLGKEMKLYFAQTLHIGSSHLAPPNPDKQFLISPPASPPVGWKQVEDATPVINYDLLYAISKLGPGEKYELHAATDTTPSVVVHVCESDQEKEEEEEMERMRRPKPKIIQTRRPEYTPIHLS
uniprot
proteins
function
FUNCTION: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A (PubMed:12809556). Could play a role during central nervous system development (By similarity). {ECO:0000250|UniProtKB:Q9JHG6, ECO:0000269|PubMed:12809556}.
uniprot
proteins
mass_dalton
28079
uniprot
proteins
mutagenesis
MUTAGEN 163; /note="S->A: Loss of phosphorylation, no loss of interaction with PPP3CA and PPP3R1, reduced ability to inhibit calcineurin and increased protein half-life; alone or when associated with A-167."; /evidence="ECO:0000269|PubMed:12809556"; MUTAGEN 163; /note="S->E: No loss of phosphorylation and no effect on protein half-life; alone or when associated with E-167."; /evidence="ECO:0000269|PubMed:12809556"; MUTAGEN 167; /note="S->A: Loss of phosphorylation, no loss of interaction with PPP3CA and PPP3R1, reduced ability to inhibit calcineurin and increased protein half-life; alone or when associated with A-163."; /evidence="ECO:0000269|PubMed:12809556"; MUTAGEN 167; /note="S->E: No loss of phosphorylation and no effect on protein half-life; alone or when associated with E-163."; /evidence="ECO:0000269|PubMed:12809556
uniprot
proteins
post_translational_modification
PTM: Phosphorylation increases its ability to inhibit calcineurin and decreases protein half-life. {ECO:0000269|PubMed:12809556}.
uniprot
proteins
protein_family
RCAN family
uniprot
proteins
pubmed
10830953
uniprot
proteins
pubmed
10861295
uniprot
proteins
pubmed
12809556
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15935327
uniprot
proteins
pubmed
8595418
uniprot
proteins
pubmed
9325060
uniprot
proteins
sequence_length
252
uniprot
proteins