Atxn10
entrez
170821
canonical
uniprot
Q9ER24
canonical
ensembl
ENSRNOG00000014637
resolver
ensembl
ENSRNOG00055031606
resolver
ensembl
ENSRNOG00060029071
resolver
ensembl
ENSRNOG00065032931
resolver
ensp
ENSRNOP00000021071
resolver
ensp
ENSRNOP00055045265
resolver
ensp
ENSRNOP00060042098
resolver
ensp
ENSRNOP00065046647
resolver
enst
ENSRNOT00055054764
resolver
enst
ENSRNOT00060050590
resolver
enst
ENSRNOT00065056668
resolver
genesymbol
Atxn10
resolver
genesymbol_syn
Sca10
resolver
uniprot_entry
ATX10_RAT
resolver
amino_acid_sequence
MAAPRMPPSRLSGIMVPAPIQDLEALRALTALFKEQRNRETAPRTIFQRVLDILKKSTQAVELACRDPSQVEHLASSLQLITECFRCLRNACIECSVNQNSIRNLDTIGVAVDLVLLFRELRVEQDSLLTAFRCGLQFLGNVASRNEDSQSIVWVHAFPELFMSCLNHPDKKIVAYCSMILFTSLNSERMKDLEENLNIAINVIEAHQKHPESEWPFLIITDHFLKSPELVEAMYGKLSNQERVTLLDIMIAKIVGDEQLTKDDISIFLRHAELIANSFVDQCRNVLKLTSEPQTEDKEALVTIRLLDVLCEMTSNTELLGYLQVFPGLMERVIDVLRVIHSVGKDSTNIFSPSDSLKAEGDIEHMTEGFKSHLIRLIGNLCYKNKENQDKVNELDGIPLILDSSNIDDNNPFMMQWVVYAVRNLTEDNSQNQDFIAKMEEQGLADASLLKKMGFEVEKSGDKLILKSNNDIPPP
uniprot
proteins
function
FUNCTION: May play a role in the regulation of cytokinesis (By similarity). May play a role in signaling by stimulating protein glycosylation (PubMed:16714295). Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the survival of cerebellar neurons (PubMed:15201271, PubMed:16498633). Does not appear to play a major role in ciliogenesis (By similarity). {ECO:0000250|UniProtKB:P28658, ECO:0000250|UniProtKB:Q9UBB4, ECO:0000269|PubMed:15201271, ECO:0000269|PubMed:16498633, ECO:0000269|PubMed:16714295}.
uniprot
proteins
mass_dalton
53727
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated. {ECO:0000250|UniProtKB:Q9UBB4}.; PTM: Phosphorylation at Ser-12 by AURKB promotes the association of ATXN10 with PLK1. Phosphorylation at Ser-77 and Thr-82 by PLK1 may play a role in the regulation of cytokinesis and may stimulate the proteasome-mediated degradation of ATXN10. {ECO:0000250|UniProtKB:Q9UBB4}.
uniprot
proteins
protein_family
Ataxin-10 family
uniprot
proteins
pubmed
15201271
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16498633
uniprot
proteins
pubmed
16714295
uniprot
proteins
sequence_length
475
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15201271}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9UBB4}. Midbody {ECO:0000250|UniProtKB:Q9UBB4}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:P28658}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:P28658}. Note=Localizes to the midbody during telophase. {ECO:0000250|UniProtKB:Q9UBB4}.
uniprot
proteins