DIS3L
entrez
115752
canonical
uniprot
Q8TF46
canonical
ensembl
ENSG00000166938
resolver
ensp
ENSP00000321583
resolver
ensp
ENSP00000321711
resolver
ensp
ENSP00000703828
resolver
genesymbol
DIS3L
resolver
genesymbol_syn
DIS3L1
resolver
genesymbol_syn
KIAA1955
resolver
hgnc
HGNC:28698
resolver
uniprot
Q8N1N8
resolver
uniprot
Q8WTU9
resolver
uniprot
Q96CM7
resolver
uniprot_entry
DI3L1_HUMAN
resolver
uniprot_sec
Q8N1N8
resolver
uniprot_sec
Q8WTU9
resolver
uniprot_sec
Q96CM7
resolver
amino_acid_sequence
MLQKREKVLLLRTFQGRTLRIVREHYLRPCVPCHSPLCPQPAACSHDGKLLSSDVTHYVIPDWKVVQDYLEILEFPELKGIIFMQTACQAVQHQRGRRQYNKLRNLLKDARHDCILFANEFQQCCYLPRERGESMEKWQTRSIYNAAVWYYHHCQDRMPIVMVTEDEEAIQQYGSETEGVFVITFKNYLDNFWPDLKAAHELCDSILQSRRERENESQESHGKEYPEHLPLEVLEAGIKSGRYIQGILNVNKHRAQIEAFVRLQGASSKDSDLVSDILIHGMKARNRSIHGDVVVVELLPKNEWKGRTVALCENDCDDKASGESPSEPMPTGRVVGILQKNWRDYVVTFPSKEEVQSQGKNAQKILVTPWDYRIPKIRISTQQAETLQDFRVVVRIDSWESTSVYPNGHFVRVLGRIGDLEGEIATILVENSISVIPFSEAQMCEMPVNTPESPWKVSPEEEQKRKDLRKSHLVFSIDPKGCEDVDDTLSVRTLNNGNLELGVHIADVTHFVAPNSYIDIEARTRATTYYLADRRYDMLPSVLSADLCSLLGGVDRYAVSIMWELDKASYEIKKVWYGRTIIRSAYKLFYEAAQELLDGNLSVVDDIPEFKDLDEKSRQAKLEELVWAIGKLTDIARHVRAKRDGCGALELEGVEVCVQLDDKKNIHDLIPKQPLEVHETVAECMILANHWVAKKIWESFPHQALLRQHPPPHQEFFSELRECAKAKGFFIDTRSNKTLADSLDNANDPHDPIVNRLLRSMATQAMSNALYFSTGSCAEEEFHHYGLALDKYTHFTSPIRRYSDIVVHRLLMAAISKDKKMEIKGNLFSNKDLEELCRHINNRNQAAQHSQKQSTELFQCMYFKDKDPATEERCISDGVIYSIRTNGVLLFIPRFGIKGAAYLKNKDGLVISCGPDSCSEWKPGSLQRFQNKITSTTTDGESVTFHLFDHVTVRISIQASRCHSDTIRLEIISNKPYKIPNTELIHQSSPLLKSELVKEVTKSVEEAQLAQEVKVNIIQEEYQEYRQTKGRSLYTLLEEIRDLALLDVSNNYGI
uniprot
proteins
ec_number
3.1.13.1
uniprot
proteins
function
FUNCTION: Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events (PubMed:20531386, PubMed:20531389, PubMed:37602378). In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA (PubMed:20531386, PubMed:20531389). {ECO:0000269|PubMed:20531386, ECO:0000269|PubMed:20531389, ECO:0000269|PubMed:37602378}.
uniprot
proteins
mass_dalton
120787
uniprot
proteins
mutagenesis
MUTAGEN 62; /note="D->N: No change of exonuclease activity."; /evidence="ECO:0000269|PubMed:20531389"; MUTAGEN 166; /note="D->N: No change of exonuclease activity."; /evidence="ECO:0000269|PubMed:20531389"; MUTAGEN 486; /note="D->N: Complete loss of exonuclease activity."; /evidence="ECO:0000269|PubMed:20531386, ECO:0000269|PubMed:20531389
uniprot
proteins
protein_family
RNR ribonuclease family
uniprot
proteins
pubmed
11853319
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
20531386
uniprot
proteins
pubmed
20531389
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
37602378
uniprot
proteins
sequence_length
1054
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20531386, ECO:0000269|PubMed:20531389}.
uniprot
proteins