Irf2
entrez
16363
canonical
uniprot
P23906
canonical
ensembl
ENSMUSG00000031627
resolver
ensp
ENSMUSP00000034041
resolver
ensp
ENSMUSP00000198808
resolver
ensp
ENSMUSP00000198809
resolver
enst
ENSMUST00000034041
resolver
genesymbol
Irf2
resolver
uniprot
Q3U2Z2
resolver
uniprot_entry
IRF2_MOUSE
resolver
uniprot_entry
Q3U2Z2_MOUSE
resolver
amino_acid_sequence
MPVERMRMRPWLEEQINSNTIPGLKWLNKEKKIFQIPWMHAARHGWDVEKDAPLFRNWAIHTGKHQPGIDKPDPKTWKANFRCAMNSLPDIEEVKDRSIKKGNNAFRVYRMLPLSERPSKKGKKPKTEKEERVKHIKQEPVESSLGLSNGVSGFSPEYAVLTSAIKNEVDSTVNIIVVGQSHLDSNIEDQEIVTNPPDICQVVEVTTESDDQPVSMSELYPLQISPVSSYAESETTDSVASDEENAEGRPHWRKRSIEGKQYLSNMGTRNTYLLPSMATFVTSNKPDLQVTIKEDSCPMPYNSSWPPFTDLPLPAPVTPTPSSSRPDRETRASVIKKTSDITQARVKSC
uniprot
proteins
function
FUNCTION: DNA-binding transcription factor that specifically binds to the upstream regulatory region of type I interferon (IFN) and IFN-inducible genes and regulates their expression (PubMed:2208287, PubMed:2475256, PubMed:8402903, PubMed:8475044). Mainly acts as a transcription repressor, repressing expression (PubMed:2208287, PubMed:2475256). Also acts as an activator for several genes including H4 and IL7 (By similarity). Constitutively binds to the ISRE promoter to activate IL7 (By similarity). Involved in cell cycle regulation through binding the site II (HiNF-M) promoter region of H4 and activating transcription during cell growth (By similarity). Antagonizes IRF1 transcriptional activation (PubMed:2208287, PubMed:2475256). {ECO:0000250|UniProtKB:P14316, ECO:0000269|PubMed:2208287, ECO:0000269|PubMed:2475256, ECO:0000269|PubMed:8402903, ECO:0000269|PubMed:8475044}.
uniprot
proteins
mass_dalton
39453
uniprot
proteins
post_translational_modification
PTM: Acetylated by CBP/ p300 during cell-growth. Acetylation on Lys-75 is required for stimulation of H4 promoter activity (By similarity). {ECO:0000250|UniProtKB:P14316}.; PTM: The major sites of sumoylation are Lys-137 and Lys-293. Sumoylation with SUMO1 increases its transcriptional repressor activity on IRF1 and diminishes its ability to activate ISRE and H4 promoter (By similarity). {ECO:0000250|UniProtKB:P14316}.
uniprot
proteins
protein_family
IRF family
uniprot
proteins
pubmed
10487755
uniprot
proteins
pubmed
2208287
uniprot
proteins
pubmed
2475256
uniprot
proteins
pubmed
8402903
uniprot
proteins
pubmed
8475044
uniprot
proteins
pubmed
9562558
uniprot
proteins
sequence_length
349
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:2475256}. Chromosome {ECO:0000269|PubMed:2475256}.
uniprot
proteins