Eya3
entrez
14050
canonical
uniprot
P97480
canonical
ensembl
ENSMUSG00000028886
resolver
ensp
ENSMUSP00000020197
resolver
ensp
ENSMUSP00000078157
resolver
ensp
ENSMUSP00000080425
resolver
ensp
ENSMUSP00000123045
resolver
ensp
ENSMUSP00000241500
resolver
enst
ENSMUST00000081726
resolver
genesymbol
Eya3
resolver
uniprot
F6T726
resolver
uniprot
G5E8I5
resolver
uniprot
P97768
resolver
uniprot
Q3TP96
resolver
uniprot
Q6P4T3
resolver
uniprot_entry
EYA3_MOUSE
resolver
uniprot_entry
F6T726_MOUSE
resolver
uniprot_entry
Q3TP96_MOUSE
resolver
uniprot_entry
Q6P4T3_MOUSE
resolver
uniprot_sec
G5E8I5
resolver
uniprot_sec
P97768
resolver
amino_acid_sequence
MQEPREQTLSQVNNPDASDEKPETSSLASNLSMSEEIMTCTDYIPRSSNDYTSQMYSAKPYAHILSVPVSETTYPGQTQYQTLQQSQPYAVYPQATQTYGLPPFASSTNASLIPTSSAIANIPAAAVASISNQDYPTYTILGQNQYQACYPSSSFGVTGQTNSDAETTTLAATTYQTEKPSAMVPAPATQRLPSDSSASPPLSQTTPNKDADDQARKNMTVKNRGKRKADASSSQDSELERVFLWDLDETIIIFHSLLTGSYAQKYGKDPTVVIGSGLTMEEMIFEVADTHLFFNDLEECDQVHVEDVASDDNGQDLSNYSFSTDGFSGSGGSGSHGSSVGVQGGVDWMRKLAFRYRKVREIYDKHKSNVGGLLSPQRKEALQRLRAEIEVLTDSWLGTALKSLLLIQSRKNCANVLITTTQLVPALAKVLLYGLGEIFPIENIYSATKIGKESCFERIVSRFGKKVTYVVIGDGRDEEIAAKQHNMPFWRITNHGDLVSLHQALELDFL
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (By similarity). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. The phosphatase activity has been shown in vitro. Coactivates SIX1. Seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity. May be involved in development of the eye. May play a role in mediating the induction and differentiation of cranial placodes. {ECO:0000250|UniProtKB:Q99504, ECO:0000269|PubMed:10490620}.
uniprot
proteins
mass_dalton
55973
uniprot
proteins
mutagenesis
MUTAGEN 246; /note="D->A: Abolishes phosphatase activity and abolishes coactivation of the SIX1-DACH1 complex."; /evidence="ECO:0000269|PubMed:14628042, ECO:0000269|PubMed:14628052, ECO:0000269|PubMed:14628053"; MUTAGEN 246; /note="D->N: Abolishes phosphatase activity."; /evidence="ECO:0000269|PubMed:14628042, ECO:0000269|PubMed:14628052, ECO:0000269|PubMed:14628053"; MUTAGEN 248; /note="D->N: Abolishes phosphatase activity."; /evidence="ECO:0000269|PubMed:14628052"; MUTAGEN 250; /note="T->A: Abolishes phosphatase activity."; /evidence="ECO:0000269|PubMed:14628052"; MUTAGEN 419; /note="T->A: Diminishes phosphatase activity by 24-fold."; /evidence="ECO:0000269|PubMed:14628052"; MUTAGEN 420; /note="T->A: Diminishes phosphatase activity."; /evidence="ECO:0000269|PubMed:14628053"; MUTAGEN 449; /note="K->Q: Abolishes phosphatase activity."; /evidence="ECO:0000269|PubMed:14628053"; MUTAGEN 473; /note="G->A: Abolishes phosphatase activity."; /evidence="ECO:0000269|PubMed:14628052"; MUTAGEN 474; /note="D->N: Diminishes phosphatase activity by 70%."; /evidence="ECO:0000269|PubMed:14628052, ECO:0000269|PubMed:14628053"; MUTAGEN 478; /note="E->Q: Abolishes phosphatase activity."; /evidence="ECO:0000269|PubMed:14628052, ECO:0000269|PubMed:14628053
uniprot
proteins
post_translational_modification
PTM: Ser-203 phosphorylation is required for localization at sites of DNA damage and directing interaction with H2AX. {ECO:0000250}.
uniprot
proteins
protein_family
EYA family
uniprot
proteins
protein_family
HAD-like hydrolase superfamily
uniprot
proteins
pubmed
10490620
uniprot
proteins
pubmed
12215533
uniprot
proteins
pubmed
14628042
uniprot
proteins
pubmed
14628052
uniprot
proteins
pubmed
14628053
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9006082
uniprot
proteins
pubmed
9049631
uniprot
proteins
pubmed
9887327
uniprot
proteins
sequence_length
510
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10490620}. Nucleus {ECO:0000269|PubMed:10490620, ECO:0000269|PubMed:14628052}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). {ECO:0000250|UniProtKB:Q99504}.
uniprot
proteins