NT5E
entrez
4907
canonical
uniprot
P21589
canonical
ensembl
ENSG00000135318
resolver
ensp
ENSP00000257770
resolver
ensp
ENSP00000358665
resolver
genesymbol
NT5E
resolver
genesymbol_syn
NT5
resolver
genesymbol_syn
NTE
resolver
hgnc
HGNC:8021
resolver
uniprot
B3KQI8
resolver
uniprot
O75520
resolver
uniprot
Q5W116
resolver
uniprot
Q6NZX3
resolver
uniprot_entry
5NTD_HUMAN
resolver
uniprot_entry
Q6NZX3_HUMAN
resolver
uniprot_sec
B3KQI8
resolver
uniprot_sec
O75520
resolver
uniprot_sec
Q5W116
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by adenosine 5'-(alpha,beta-methylene)-diphosphate (AMPCP). {ECO:0000269|PubMed:22997138, ECO:0000269|PubMed:23142347, ECO:0000269|PubMed:34403084}.
uniprot
proteins
amino_acid_sequence
MCPRAARAPATLLLALGAVLWPAAGAWELTILHTNDVHSRLEQTSEDSSKCVNASRCMGGVARLFTKVQQIRRAEPNVLLLDAGDQYQGTIWFTVYKGAEVAHFMNALRYDAMALGNHEFDNGVEGLIEPLLKEAKFPILSANIKAKGPLASQISGLYLPYKVLPVGDEVVGIVGYTSKETPFLSNPGTNLVFEDEITALQPEVDKLKTLNVNKIIALGHSGFEMDKLIAQKVRGVDVVVGGHSNTFLYTGNPPSKEVPAGKYPFIVTSDDGRKVPVVQAYAFGKYLGYLKIEFDERGNVISSHGNPILLNSSIPEDPSIKADINKWRIKLDNYSTQELGKTIVYLDGSSQSCRFRECNMGNLICDAMINNNLRHTDEMFWNHVSMCILNGGGIRSPIDERNNGTITWENLAAVLPFGGTFDLVQLKGSTLKKAFEHSVHRYGQSTGEFLQVGGIHVVYDLSRKPGDRVVKLDVLCTKCRVPSYDPLKMDEVYKVILPNFLANGGDGFQMIKDELLRHDSGDQDINVVSTYISKMKVIYPAVEGRIKFSTGSHCHGSFSLIFLSLWAVIFVLYQ
uniprot
proteins
disease_involvement
DISEASE: Calcification of joints and arteries (CALJA) [MIM:211800]: A condition characterized by adult-onset calcification of the lower extremity arteries, including the iliac, femoral and tibial arteries, and hand and foot capsule joints. Age of onset has been reported as early as the second decade of life, usually involving intense joint pain or calcification in the hands. {ECO:0000269|PubMed:21288095, ECO:0000269|PubMed:24887587}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.1.3.35
uniprot
proteins
ec_number
3.1.3.5
uniprot
proteins
ec_number
3.1.3.89
uniprot
proteins
ec_number
3.1.3.91
uniprot
proteins
ec_number
3.1.3.99
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of nucleotide monophosphates, releasing inorganic phosphate and the corresponding nucleoside, with AMP being the preferred substrate (PubMed:21933152, PubMed:22997138, PubMed:23142347, PubMed:24887587, PubMed:34403084). Shows a preference for ribonucleotide monophosphates over their equivalent deoxyribose forms (PubMed:34403084). Other substrates include IMP, UMP, GMP, CMP, dAMP, dCMP, dTMP, NAD and NMN (PubMed:21933152, PubMed:22997138, PubMed:23142347, PubMed:24887587, PubMed:34403084). {ECO:0000269|PubMed:21933152, ECO:0000269|PubMed:22997138, ECO:0000269|PubMed:23142347, ECO:0000269|PubMed:24887587, ECO:0000269|PubMed:34403084}.
uniprot
proteins
mass_dalton
63368
uniprot
proteins
protein_family
5'-nucleotidase family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
21288095
uniprot
proteins
pubmed
2129526
uniprot
proteins
pubmed
2173922
uniprot
proteins
pubmed
21933152
uniprot
proteins
pubmed
22997138
uniprot
proteins
pubmed
23142347
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24887587
uniprot
proteins
pubmed
34403084
uniprot
proteins
pubmed
8566797
uniprot
proteins
sequence_length
574
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:2129526, ECO:0000269|PubMed:24887587}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:2129526}.
uniprot
proteins