ARNT
entrez
405
canonical
uniprot
P27540
canonical
ensembl
ENSG00000143437
resolver
ensp
ENSP00000346372
resolver
ensp
ENSP00000351407
resolver
ensp
ENSP00000423851
resolver
ensp
ENSP00000427571
resolver
ensp
ENSP00000574378
resolver
ensp
ENSP00000574379
resolver
ensp
ENSP00000574380
resolver
ensp
ENSP00000574381
resolver
ensp
ENSP00000574382
resolver
ensp
ENSP00000574383
resolver
ensp
ENSP00000574391
resolver
ensp
ENSP00000591750
resolver
ensp
ENSP00000591751
resolver
ensp
ENSP00000618916
resolver
ensp
ENSP00000648525
resolver
ensp
ENSP00000703094
resolver
genesymbol
ARNT
resolver
genesymbol_syn
BHLHE2
resolver
hgnc
HGNC:700
resolver
uniprot
A8K6P0
resolver
uniprot
B0AZM1
resolver
uniprot
B2R9H1
resolver
uniprot
C4AMA1
resolver
uniprot
F8WAP6
resolver
uniprot
Q53F30
resolver
uniprot
Q59ED4
resolver
uniprot
Q5QP39
resolver
uniprot
Q8NDC7
resolver
uniprot_entry
A8K6P0_HUMAN
resolver
uniprot_entry
ARNT_HUMAN
resolver
uniprot_entry
B0AZM1_HUMAN
resolver
uniprot_entry
Q53F30_HUMAN
resolver
uniprot_sec
B2R9H1
resolver
uniprot_sec
C4AMA1
resolver
uniprot_sec
F8WAP6
resolver
uniprot_sec
Q59ED4
resolver
uniprot_sec
Q5QP39
resolver
uniprot_sec
Q8NDC7
resolver
amino_acid_sequence
MAATTANPEMTSDVPSLGPAIASGNSGPGIQGGGAIVQRAIKRRPGLDFDDDGEGNSKFLRCDDDQMSNDKERFARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMVPTCSALARKPDKLTILRMAVSHMKSLRGTGNTSTDGSYKPSFLTDQELKHLILEAADGFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDDVDKLREQLSTSENALTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICRMRCGSSSVDPVSVNRLSFVRNRCRNGLGSVKDGEPHFVVVHCTGYIKAWPPAGVSLPDDDPEAGQGSKFCLVAIGRLQVTSSPNCTDMSNVCQPTEFISRHNIEGIFTFVDHRCVATVGYQPQELLGKNIVEFCHPEDQQLLRDSFQQVVKLKGQVLSVMFRFRSKNQEWLWMRTSSFTFQNPYSDEIEYIICTNTNVKNSSQEPRPTLSNTIQRPQLGPTANLPLEMGSGQLAPRQQQQQTELDMVPGRDGLASYNHSQVVQPVTTTGPEHSKPLEKSDGLFAQDRDPRFSEIYHNINADQSKGISSSTVPATQQLFSQGNTFPPTPRPAENFRNSGLAPPVTIVQPSASAGQMLAQISRHSNPTQGATPTWTPTTRSGFSAQQVATQATAKTRTSQFGVGSFQTPSSFSSMSLPGAPTASPGAAAYPSLTNRGSNFAPETGQTAGQFQTRTAEGVGVWPQWQGQQPHHRSSSSEQHVQQPPAQQPGQPEVFQEMLSMLGDQSNSYNNEEFPDLTMFPPFSE
uniprot
proteins
function
FUNCTION: Transcription factor that functions as an obligate heterodimerization partner for several basic helix-loop-helix PER-ARNT-SIM (bHLH-PAS) proteins. Forms heterodimers with the aryl hydrocarbon receptor (AHR) to mediate the transcriptional response to xenobiotics by binding xenobiotic response elements (XREs) or dioxin response elements (DREs) in target gene promoters (PubMed:28396409, PubMed:34521881). Also heterodimerizes with hypoxia-inducible factor alpha subunits (HIF1A, EPAS1, NPAS1 or NPAS3) to form hypoxia-inducible transcription factors that bind hypoxia response elements (HREs) and activate genes involved in cellular and systemic responses to hypoxia, including angiogenesis, erythropoiesis, and metabolic adaptation (PubMed:16181639, PubMed:20699359). Plays a central role in environmental sensing and developmental and physiological regulation of gene expression (PubMed:34521881). {ECO:0000269|PubMed:16181639, ECO:0000269|PubMed:20699359, ECO:0000269|PubMed:28396409, ECO:0000269|PubMed:34521881}.
uniprot
proteins
mass_dalton
86636
uniprot
proteins
mutagenesis
MUTAGEN 91; /note="R->A: Diminishes DNA interaction."; /evidence="ECO:0000269|PubMed:8621524"; MUTAGEN 93; /note="N->A: Diminishes DNA interaction."; /evidence="ECO:0000269|PubMed:8621524"; MUTAGEN 94; /note="H->A: Severely diminishes DNA interaction."; /evidence="ECO:0000269|PubMed:8621524"; MUTAGEN 98; /note="E->A: Severely diminishes DNA interaction."; /evidence="ECO:0000269|PubMed:8621524"; MUTAGEN 99; /note="R->A: Diminishes DNA interaction."; /evidence="ECO:0000269|PubMed:8621524"; MUTAGEN 101; /note="R->A: Severely diminishes DNA interaction."; /evidence="ECO:0000269|PubMed:8621524"; MUTAGEN 102; /note="R->A: Severely diminishes DNA interaction."; /evidence="ECO:0000269|PubMed:8621524
uniprot
proteins
pubmed
10395741
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
1317062
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16181639
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
1852076
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19196990
uniprot
proteins
pubmed
20699359
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28396409
uniprot
proteins
pubmed
28904176
uniprot
proteins
pubmed
34521881
uniprot
proteins
pubmed
7539918
uniprot
proteins
pubmed
8621524
uniprot
proteins
sequence_length
789
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:34521881}.
uniprot
proteins