Slc45a2
entrez
22293
canonical
uniprot
P58355
canonical
ensembl
ENSMUSG00000022243
resolver
ensp
ENSMUSP00000112408
resolver
enst
ENSMUST00000117100
resolver
genesymbol
Slc45a2
resolver
genesymbol_syn
Aim1
resolver
genesymbol_syn
Matp
resolver
genesymbol_syn
Mstp1
resolver
genesymbol_syn
uw
resolver
uniprot
D3YWT7
resolver
uniprot
Q541S3
resolver
uniprot_entry
Q541S3_MOUSE
resolver
uniprot_entry
S45A2_MOUSE
resolver
uniprot_sec
D3YWT7
resolver
amino_acid_sequence
MSGSNGPTDTHTYQSLAEDCPFGSVEQPKRSTGRLVMHSMAMFGREFCYAVEAAYVTPVLLSVGLPKSLYSMVWLLSPILGFLLQPVVGSASDHCRARWGRRRPYILTLAIMMLLGMALYLNGDAVVSALVANPRQKLIWAISITMVGVVLFDFSADFIDGPIKAYLFDVCSHQDKEKGLHYHALFTGFGGALGYILGAIDWVHLDLGRLLGTEFQVMFFFSALVLILCFITHLCSIPEAPLRDAATDPPSQQDPQGSSLSASGMHEYGSIEKVKNGGADTEQPVQEWKNKKPSGQSQRTMSMKSLLRALVNMPSHYRCLCVSHLIGWTAFLSNMLFFTDFMGQIVYHGDPYGAHNSTEFLIYERGVEVGCWGLCINSVFSSVYSYFQKAMVSYIGLKGLYFMGYLLFGLGTGFIGLFPNVYSTLVLCSMFGVMSSTLYTVPFNLIAEYHREEEKEKGQEAPGGPDNQGRGKGVDCAALTCMVQLAQILVGGGLGFLVNMAGSVVVVVITASAVSLIGCCFVALFVRYVD
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Slc45a2 are the cause of the UW-dbr phenotype that results in loss of nearly all pigmentation in the homozygous state. {ECO:0000269|PubMed:11574907}.
uniprot
proteins
function
FUNCTION: Proton-associated glucose and sucrose transporter (PubMed:25164149, PubMed:35469906). May be able to transport also fructose (PubMed:25164149). Expressed at a late melanosome maturation stage where functions as a proton/glucose exporter which increase lumenal pH by decreasing glycolysis (PubMed:32966160, PubMed:35469906). Regulates melanogenesis by maintaining melanosome neutralization that is initially initiated by transient OCA2 and required for a proper function of the tyrosinase TYR (PubMed:32966160, PubMed:35469906). {ECO:0000269|PubMed:25164149, ECO:0000269|PubMed:32966160, ECO:0000269|PubMed:35469906}.
uniprot
proteins
mass_dalton
57961
uniprot
proteins
protein_family
Glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family
uniprot
proteins
pubmed
11479596
uniprot
proteins
pubmed
11574907
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
25164149
uniprot
proteins
pubmed
32966160
uniprot
proteins
pubmed
35469906
uniprot
proteins
sequence_length
530
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Melanosome membrane {ECO:0000269|PubMed:32966160}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 46..66; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 69..89; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 106..126; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 139..159; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 185..205; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 217..237; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 319..339; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 367..387; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 399..419; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 426..446; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 478..498; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 505..525; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins