P13838
uniprot
P13838
canonical
amino_acid_sequence
WAQVVSQENLPNTMTMLPFTPNSESPSTSEALSTYSSIATVPVTEDPKESISPWGQTTAPASSIPLGTPELSSFFFTSAGASGNTPVPELTTSQEVSTEASLVLFPKSSGVASDPPVTITNPATSSAVASTSLETFKGTSAPPVTVTSSTMTSGPFVATTVSSETSGPPVTMATGSLGPSKETHGLSATIATSSGESSSVAGGTPVFSTKISTTSTPNPITTVPPRPGSSGMLLVSMLIALTVVLVLVALLLLWRQRQKRRTGALTLSRGGKRNGTVDAWAGPARVPDEEATTASGSGGNKSSGAPETDGSGQRPTLTTFFSRRKSRQGSVALEELKPGTGPNLKGEEEPLVGSEDEAVETPTSDGPQAKDGAAPQSL
uniprot
proteins
function
FUNCTION: Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells. Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR. Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1. {ECO:0000250|UniProtKB:P15702, ECO:0000250|UniProtKB:P16150}.; FUNCTION: [CD43 cytoplasmic tail]: Protects cells from apoptotic signals, promoting cell survival. {ECO:0000250|UniProtKB:P15702}.
uniprot
proteins
mass_dalton
38426
uniprot
proteins
mutagenesis
MUTAGEN 259..261; /note="KRR->NGG: Loss of interaction with EZR, MSN and RDX and co-localization to microvilli."; /evidence="ECO:0000269|PubMed:9472040
uniprot
proteins
post_translational_modification
PTM: Has a high content of sialic acid and O-linked carbohydrate structures.; PTM: Phosphorylation at Ser-330 is regulated by chemokines, requires its association with ERM proteins (EZR, RDX and MSN) and is essential for its function in the regulation of T-cell trafficking to lymph nodes. {ECO:0000250|UniProtKB:P15702}.; PTM: Cleavage by CTSG releases its extracellular domain and triggers its intramembrane proteolysis by gamma-secretase releasing the CD43 cytoplasmic tail chain (CD43-ct) which translocates to the nucleus. {ECO:0000250|UniProtKB:P15702}.; PTM: [CD43 cytoplasmic tail]: Sumoylated. {ECO:0000250|UniProtKB:P15702}.
uniprot
proteins
pubmed
11238599
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2965006
uniprot
proteins
pubmed
9472040
uniprot
proteins
sequence_length
378
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, microvillus {ECO:0000269|PubMed:9472040}. Cell projection, uropodium {ECO:0000250|UniProtKB:P15702}. Note=Localizes to the uropodium and microvilli via its interaction with ERM proteins (EZR, RDX and MSN). {ECO:0000250|UniProtKB:P15702, ECO:0000269|PubMed:9472040}.; SUBCELLULAR LOCATION: [CD43 cytoplasmic tail]: Nucleus {ECO:0000250|UniProtKB:P15702}. Nucleus, PML body {ECO:0000250|UniProtKB:P15702}. Note=The sumoylated form localizes to the PML body. {ECO:0000250|UniProtKB:P15702}.
uniprot
proteins
transmembrane_region
TRANSMEM 232..254; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins