Tdg
entrez
21665
canonical
uniprot
P56581
canonical
ensembl
ENSMUSG00000034674
resolver
ensp
ENSMUSP00000089917
resolver
ensp
ENSMUSP00000121000
resolver
ensp
ENSMUSP00000354208
resolver
genesymbol
Tdg
resolver
uniprot
Q3TPW4
resolver
uniprot
Q542A9
resolver
uniprot
Q5U3M4
resolver
uniprot
Q5U3M5
resolver
uniprot
Q6PJW4
resolver
uniprot
Q8BPK0
resolver
uniprot_entry
TDG_MOUSE
resolver
uniprot_sec
Q3TPW4
resolver
uniprot_sec
Q542A9
resolver
uniprot_sec
Q5U3M4
resolver
uniprot_sec
Q5U3M5
resolver
uniprot_sec
Q6PJW4
resolver
uniprot_sec
Q8BPK0
resolver
amino_acid_sequence
MDAEAARSYSLEQVQALYSFPFQQMMAEVPNMAVTTGQQVPAVAPNMATVTEQQVPEDAPVQEPAPEAPKRRKRKPRAAEPQEPVEPKKPATSKKSGKSTKSKEKQEKITDAFKVKRKVDRFNGVSEAELLTKTLPDILTFNLDIVIIGINPGLMAAYKGHHYPGPGNHFWKCLFMSGLSEVQLNHMDDHTLPGKYGIGFTNMVERTTPGSKDLSSKEFREGGRILVQKLQKYQPRIAVFNGKCIYEIFSKEVFGVKVKNLEFGLQPHKIPDTETLCYVMPSSSARCAQFPRAQDKVHYYIKLKDLRDQLKGIERNADVQEVQYTFDLQLAQEDAKKMAVKEEKYDPGYEAAYGGAYGENPCNGEPCGIASNGLTAHSAEPRGEAAPSDVPNGQWMAQSFAEQIPSFNNCGTREQEEESHA
uniprot
proteins
ec_number
3.2.2.29
uniprot
proteins
function
FUNCTION: DNA glycosylase that plays a key role in active DNA demethylation: specifically recognizes and binds 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in the context of CpG sites and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine (PubMed:21817016). Cannot remove 5-hydroxymethylcytosine (5hmC). According to an alternative model, involved in DNA demethylation by mediating DNA glycolase activity toward 5-hydroxymethyluracil (5hmU) produced by deamination of 5hmC (PubMed:21722948). Also involved in DNA repair by acting as a thymine-DNA glycosylase that mediates correction of G/T mispairs to G/C pairs: in the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. Its role in the repair of canonical base damage is however minor compared to its role in DNA demethylation. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine. {ECO:0000269|PubMed:21278727, ECO:0000269|PubMed:21722948, ECO:0000269|PubMed:21817016}.
uniprot
proteins
mass_dalton
46879
uniprot
proteins
mutagenesis
MUTAGEN 151; /note="N->A: Loss of DNA glycosylase activity."; /evidence="ECO:0000269|PubMed:21278727, ECO:0000269|PubMed:21722948, ECO:0000269|PubMed:21817016
uniprot
proteins
post_translational_modification
PTM: Sumoylation on Lys-341 by either SUMO1 or SUMO2 induces dissociation of the product DNA. {ECO:0000250}.
uniprot
proteins
protein_family
TDG/mug family
uniprot
proteins
protein_family
Uracil-DNA glycosylase (UDG) superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1631061
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21278727
uniprot
proteins
pubmed
21722948
uniprot
proteins
pubmed
21817016
uniprot
proteins
pubmed
9694815
uniprot
proteins
sequence_length
421
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins