ELF3
entrez
1999
canonical
uniprot
P78545
canonical
ensembl
ENSG00000163435
resolver
ensp
ENSP00000356252
resolver
ensp
ENSP00000356253
resolver
ensp
ENSP00000674510
resolver
genesymbol
ELF3
resolver
genesymbol_syn
ERT
resolver
genesymbol_syn
ESX
resolver
genesymbol_syn
JEN
resolver
hgnc
HGNC:3318
resolver
uniprot
B2R5Q6
resolver
uniprot
Q6IAP8
resolver
uniprot
Q7RU03
resolver
uniprot
Q7Z3X2
resolver
uniprot
Q8NFG2
resolver
uniprot
Q99718
resolver
uniprot_entry
ELF3_HUMAN
resolver
uniprot_sec
B2R5Q6
resolver
uniprot_sec
Q6IAP8
resolver
uniprot_sec
Q7RU03
resolver
uniprot_sec
Q7Z3X2
resolver
uniprot_sec
Q8NFG2
resolver
uniprot_sec
Q99718
resolver
amino_acid_sequence
MAATCEISNIFSNYFSAMYSSEDSTLASVPPAATFGADDLVLTLSNPQMSLEGTEKASWLGEQPQFWSKTQVLDWISYQVEKNKYDASAIDFSRCDMDGATLCNCALEELRLVFGPLGDQLHAQLRDLTSSSSDELSWIIELLEKDGMAFQEALDPGPFDQGSPFAQELLDDGQQASPYHPGSCGAGAPSPGSSDVSTAGTGASRSSHSSDSGGSDVDLDPTDGKLFPSDGFRDCKKGDPKHGKRKRGRPRKLSKEYWDCLEGKKSKHAPRGTHLWEFIRDILIHPELNEGLMKWENRHEGVFKFLRSEAVAQLWGQKKKNSNMTYEKLSRAMRYYYKREILERVDGRRLVYKFGKNSSGWKEEEVLQSRN
uniprot
proteins
function
FUNCTION: Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development (By similarity). {ECO:0000250, ECO:0000269|PubMed:10391676, ECO:0000269|PubMed:10644990, ECO:0000269|PubMed:10773884, ECO:0000269|PubMed:11036073, ECO:0000269|PubMed:11313868, ECO:0000269|PubMed:12414801, ECO:0000269|PubMed:12624109, ECO:0000269|PubMed:12682075, ECO:0000269|PubMed:12713734, ECO:0000269|PubMed:14715662, ECO:0000269|PubMed:14767472, ECO:0000269|PubMed:15075319, ECO:0000269|PubMed:15169914, ECO:0000269|PubMed:15794755, ECO:0000269|PubMed:16307850, ECO:0000269|PubMed:17060315, ECO:0000269|PubMed:9129154, ECO:0000269|PubMed:9234700, ECO:0000269|PubMed:9336459, ECO:0000269|PubMed:9395241, ECO:0000269|PubMed:9417054}.
uniprot
proteins
mass_dalton
41454
uniprot
proteins
mutagenesis
MUTAGEN 247..250; /note="RGRP->AAAA: No effect on transcriptional repression on KRT4 promoter."; /evidence="ECO:0000269|PubMed:10773884"; MUTAGEN 315; /note="W->A: Partially abrogates repressive effect on the KRT4 promoter; when associated with A-319."; /evidence="ECO:0000269|PubMed:10773884"; MUTAGEN 319; /note="K->A: Partially abrogates repressive effect on the KRT4 promoter; when associated with A-315."; /evidence="ECO:0000269|PubMed:10773884"; MUTAGEN 334..337; /note="RYYY->AAAA: Partially abrogates repressive effect on the KRT4 promoter."; /evidence="ECO:0000269|PubMed:10773884
uniprot
proteins
protein_family
ETS family
uniprot
proteins
pubmed
10391676
uniprot
proteins
pubmed
10644990
uniprot
proteins
pubmed
10773884
uniprot
proteins
pubmed
11036073
uniprot
proteins
pubmed
11313868
uniprot
proteins
pubmed
12032832
uniprot
proteins
pubmed
12119107
uniprot
proteins
pubmed
12414801
uniprot
proteins
pubmed
12624109
uniprot
proteins
pubmed
12682075
uniprot
proteins
pubmed
12713734
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14715662
uniprot
proteins
pubmed
14767472
uniprot
proteins
pubmed
14997048
uniprot
proteins
pubmed
15075319
uniprot
proteins
pubmed
15169914
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15794755
uniprot
proteins
pubmed
16307850
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17060315
uniprot
proteins
pubmed
17467953
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
30476274
uniprot
proteins
pubmed
9129154
uniprot
proteins
pubmed
9234700
uniprot
proteins
pubmed
9336459
uniprot
proteins
pubmed
9395241
uniprot
proteins
pubmed
9417054
uniprot
proteins
sequence_length
371
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10391676, ECO:0000269|PubMed:15169914, ECO:0000269|PubMed:17060315}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237, ECO:0000269|PubMed:10391676, ECO:0000269|PubMed:15169914, ECO:0000269|PubMed:17060315}. Note=Localizes to the cytoplasm where it has been shown to transform MCF-12A mammary epithelial cells via a novel cytoplasmic mechanism. Also transiently expressed and localized to the nucleus where it induces apoptosis in non-transformed breast epithelial cells MCF-10A and MCF-12A via a transcription-dependent mechanism. {ECO:0000269|PubMed:10391676, ECO:0000269|PubMed:15169914, ECO:0000269|PubMed:17060315}.
uniprot
proteins