METTL6
entrez
131965
canonical
uniprot
Q8TCB7
canonical
ensembl
ENSG00000206562
resolver
ensp
ENSP00000373299
resolver
ensp
ENSP00000373300
resolver
ensp
ENSP00000407613
resolver
ensp
ENSP00000410726
resolver
ensp
ENSP00000577591
resolver
ensp
ENSP00000586186
resolver
ensp
ENSP00000586189
resolver
ensp
ENSP00000672633
resolver
ensp
ENSP00000672634
resolver
ensp
ENSP00000672635
resolver
ensp
ENSP00000693747
resolver
ensp
ENSP00000693752
resolver
ensp
ENSP00000757286
resolver
ensp
ENSP00000757287
resolver
ensp
ENSP00000757289
resolver
enst
ENST00000450816
resolver
enst
ENST00000916127
resolver
genesymbol
METTL6
resolver
hgnc
HGNC:28343
resolver
uniprot
A0ACI8SSY6
resolver
uniprot
B4DDX3
resolver
uniprot
Q96LU4
resolver
uniprot_entry
A0ACI8SSY6_HUMAN
resolver
uniprot_entry
B4DDX3_HUMAN
resolver
uniprot_entry
METL6_HUMAN
resolver
uniprot_sec
Q96LU4
resolver
amino_acid_sequence
MASLQRKGLQARILTSEEEEKLKRDQTLVSDFKQQKLEQEAQKNWDLFYKRNSTNFFKDRHWTTREFEELRSCREFEDQKLTMLEAGCGVGNCLFPLLEEDPNIFAYACDFSPRAIEYVKQNPLYDTERCKVFQCDLTKDDLLDHVPPESVDVVMLIFVLSAVHPDKMHLVLQNIYKVLKPGKSVLFRDYGLYDHAMLRFKASSKLGENFYVRQDGTRSYFFTDDFLAQLFMDTGYEEVVNEYVFRETVNKKEGLCVPRVFLQSKFLKPPKNPSPVVLGLDPKS
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Ser), including tRNA(Ser)(UGA) and tRNA(Ser)(GCU) (PubMed:32923617, PubMed:34268557, PubMed:34862464, PubMed:34922197). Interaction with SARS1/SerRS is required for N(3)-methylcytidine methylation (PubMed:34268557). {ECO:0000269|PubMed:32923617, ECO:0000269|PubMed:34268557, ECO:0000269|PubMed:34862464, ECO:0000269|PubMed:34922197}.
uniprot
proteins
mass_dalton
33251
uniprot
proteins
mutagenesis
MUTAGEN 49; /note="Y->F: Decreased affinity for S-adenosyl-L-methionine."; /evidence="ECO:0000269|PubMed:34862464"; MUTAGEN 61; /note="H->N: Decreased affinity for S-adenosyl-L-methionine."; /evidence="ECO:0000269|PubMed:34862464"; MUTAGEN 85; /note="E->Q: Strongly decreased affinity for S-adenosyl-L-methionine."; /evidence="ECO:0000269|PubMed:34862464"; MUTAGEN 93; /note="C->S: Does not affect affinity for S-adenosyl-L-methionine."; /evidence="ECO:0000269|PubMed:34862464"; MUTAGEN 110; /note="D->A: Nearly abolished affinity for S-adenosyl-L-methionine."; /evidence="ECO:0000269|PubMed:34862464"; MUTAGEN 111; /note="F->L: Decreased affinity for S-adenosyl-L-methionine."; /evidence="ECO:0000269|PubMed:34862464"; MUTAGEN 161; /note="S->A: Strongly reduced RNA (cytosine-3-)-methyltransferase activity."; /evidence="ECO:0000269|PubMed:34862464"; MUTAGEN 217; /note="T->A: Strongly reduced RNA (cytosine-3-)-methyltransferase activity."; /evidence="ECO:0000269|PubMed:34862464
uniprot
proteins
protein_family
METL family
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
28655767
uniprot
proteins
pubmed
32923617
uniprot
proteins
pubmed
34268557
uniprot
proteins
pubmed
34862464
uniprot
proteins
pubmed
34922197
uniprot
proteins
sequence_length
284
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:34268557}. Nucleus {ECO:0000269|PubMed:34268557}.
uniprot
proteins