Krt6a
entrez
16687
canonical
uniprot
P50446
canonical
ensembl
ENSMUSG00000058354
resolver
ensp
ENSMUSP00000023788
resolver
enst
ENSMUST00000023788
resolver
genesymbol
Krt6a
resolver
genesymbol_syn
Ker2
resolver
genesymbol_syn
Krt2-6
resolver
genesymbol_syn
Krt2-6a
resolver
genesymbol_syn
Krt6
resolver
uniprot
Q9Z332
resolver
uniprot_entry
K2C6A_MOUSE
resolver
uniprot_sec
Q9Z332
resolver
amino_acid_sequence
MSTKTTIKSQTSHRGYSASSARVPGLNRSGFSSVSVCRSRGSGGSSAMCGGAGFGSRSLYGVGSSKRISIGGGSCGIGGGYGSRFGGSFGIGGGAGSGFGFGGGAGFGGGYGGAGFPVCPPGGIQEVTINQSLLTPLNLQIDPTIQRVRTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWALLQEQGTKTVRQNLEPMFEQYISNLRRQLDSIIGERGRLDSELRNMQDTVEDYKSKYEDEINKRTAAENEFVTLKKDVDAAYMNKVELQAKADSLTDDINFLRALYEAELSQMQTHISDTSVVLSMDNNRSLDLDSIIAEVKAQYEDIAQRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEIAEINRMIQRLRSEIDHVKKQCANLQAAIADAEQRGEMALKDARGKLEGLEDALQKAKQDMARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLNGEGVGPVNISVVQSTVSSGYGSAGGASSSLGLGGGSSYSYSSSHGLGGGFSAGSGRAIGGGLSSSGGLSSSTIKYTTTSSSKKSYRQ
uniprot
proteins
function
FUNCTION: Structural component of intermediate filaments in epithelial keratinocytes. Forms heteropolymers with the type I keratins KRT16 and KRT17, assembling keratin intermediate filament networks that contribute to the structural integrity and stress resilience of stratified epithelia, particularly in epidermis, nail bed and oral mucosa. Rapidly induced in wound-edge keratinocytes and participates in the reorganization of the cytoskeleton during re-epithelialization (PubMed:10866680, PubMed:8636216). Negatively regulates collective keratinocyte migration by stabilizing myosin IIA/MYH2 and desmoplakin, thereby altering cell-cell and cell-matrix adhesion and reducing the speed and directionality of epithelial sheet movement during wound repair (PubMed:30389720). Also limits epithelial migration by inhibiting the activity of SRC during wound repair (PubMed:22529101). Required for normal plantar and nail unit integrity (By similarity). {ECO:0000250|UniProtKB:P02538, ECO:0000269|PubMed:10866680, ECO:0000269|PubMed:22529101, ECO:0000269|PubMed:30389720, ECO:0000269|PubMed:8636216}.
uniprot
proteins
mass_dalton
59335
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
10866680
uniprot
proteins
pubmed
11069616
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1713533
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22529101
uniprot
proteins
pubmed
30389720
uniprot
proteins
pubmed
6207530
uniprot
proteins
pubmed
8636216
uniprot
proteins
pubmed
9790766
uniprot
proteins
sequence_length
553
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:30389720}.
uniprot
proteins