MPPE1
entrez
65258
canonical
uniprot
Q53F39
canonical
ensembl
ENSG00000154889
resolver
ensp
ENSP00000311200
resolver
ensp
ENSP00000327257
resolver
ensp
ENSP00000339423
resolver
ensp
ENSP00000433950
resolver
ensp
ENSP00000465894
resolver
ensp
ENSP00000468606
resolver
ensp
ENSP00000552087
resolver
ensp
ENSP00000552088
resolver
ensp
ENSP00000552092
resolver
ensp
ENSP00000552094
resolver
ensp
ENSP00000552098
resolver
ensp
ENSP00000552099
resolver
ensp
ENSP00000552100
resolver
ensp
ENSP00000627442
resolver
ensp
ENSP00000627446
resolver
ensp
ENSP00000627447
resolver
ensp
ENSP00000627449
resolver
ensp
ENSP00000627453
resolver
ensp
ENSP00000627454
resolver
ensp
ENSP00000627457
resolver
ensp
ENSP00000627458
resolver
ensp
ENSP00000627459
resolver
ensp
ENSP00000717265
resolver
ensp
ENSP00000717266
resolver
enst
ENST00000344987
resolver
enst
ENST00000882028
resolver
enst
ENST00000882033
resolver
enst
ENST00000882039
resolver
enst
ENST00000882041
resolver
enst
ENST00000957388
resolver
genesymbol
MPPE1
resolver
genesymbol_syn
PGAP5
resolver
hgnc
HGNC:15988
resolver
uniprot
A0A0A0MR93
resolver
uniprot
B0YJ39
resolver
uniprot
B0YJ40
resolver
uniprot
B0YJ41
resolver
uniprot
B5ME53
resolver
uniprot
B7WNJ3
resolver
uniprot
D3DUI5
resolver
uniprot
D3DUI7
resolver
uniprot
Q6GMP1
resolver
uniprot
Q8TAD6
resolver
uniprot
Q8TE26
resolver
uniprot
Q8WZ32
resolver
uniprot
Q9BU58
resolver
uniprot
Q9H958
resolver
uniprot
Q9HAI4
resolver
uniprot_entry
A0A0A0MR93_HUMAN
resolver
uniprot_entry
MPPE1_HUMAN
resolver
uniprot_sec
B0YJ39
resolver
uniprot_sec
B0YJ40
resolver
uniprot_sec
B0YJ41
resolver
uniprot_sec
B5ME53
resolver
uniprot_sec
B7WNJ3
resolver
uniprot_sec
D3DUI5
resolver
uniprot_sec
D3DUI7
resolver
uniprot_sec
Q6GMP1
resolver
uniprot_sec
Q8TAD6
resolver
uniprot_sec
Q8TE26
resolver
uniprot_sec
Q8WZ32
resolver
uniprot_sec
Q9BU58
resolver
uniprot_sec
Q9H958
resolver
uniprot_sec
Q9HAI4
resolver
amino_acid_sequence
MAMIELGFGRQNFHPLKRKSSLLLKLIAVVFAVLLFCEFLIYYLAIFQCNWPEVKTTASDGEQTTREPVLKAMFLADTHLLGEFLGHWLDKLRREWQMERAFQTALWLLQPEVVFILGDIFDEGKWSTPEAWADDVERFQKMFRHPSHVQLKVVAGNHDIGFHYEMNTYKVERFEKVFSSERLFSWKGINFVMVNSVALNGDGCGICSETEAELIEVSHRLNCSREARGSSRCGPGPLLPTSAPVLLQHYPLYRRSDANCSGEDAAPAEERDIPFKENYDVLSREASQKLLWWLQPRLVLSGHTHSACEVHHGGRVPELSVPSFSWRNRNNPSFIMGSITPTDYTLSKCYLPREDVVLIIYCGVVGFLVVLTLTHFGLLASPFLSGLNLLGKRKTR
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: Metallophosphoesterase that catalyzes the removal of a side-chain ethanolamine-phosphate (EtNP) from the second mannose of the GPI-anchor protein intermediate (PubMed:19837036, PubMed:29374258). Participates in the glycan remodeling steps of GPI-anchor maturation to allow an efficient transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi (PubMed:19837036, PubMed:29374258). {ECO:0000269|PubMed:19837036, ECO:0000269|PubMed:29374258}.
uniprot
proteins
mass_dalton
45141
uniprot
proteins
mutagenesis
MUTAGEN 77; /note="D->A: Affects transport of GPI-anchor proteins."; /evidence="ECO:0000269|PubMed:19837036"; MUTAGEN 79; /note="H->A: Affects transport of GPI-anchor proteins."; /evidence="ECO:0000269|PubMed:19837036"; MUTAGEN 119; /note="D->A,N: Affects transport of GPI-anchor proteins."; /evidence="ECO:0000269|PubMed:19837036"; MUTAGEN 157; /note="N->A: Affects transport of GPI-anchor proteins."; /evidence="ECO:0000269|PubMed:19837036"; MUTAGEN 158; /note="H->A: Affects transport of GPI-anchor proteins."; /evidence="ECO:0000269|PubMed:19837036"; MUTAGEN 249; /note="H->A: Affects transport of GPI-anchor proteins."; /evidence="ECO:0000269|PubMed:19837036"; MUTAGEN 303; /note="H->A: Affects transport of GPI-anchor proteins."; /evidence="ECO:0000269|PubMed:19837036"; MUTAGEN 305; /note="H->A: Affects transport of GPI-anchor proteins."; /evidence="ECO:0000269|PubMed:19837036"; MUTAGEN 392..394; /note="KRK->ARA: Affects subcellular localization."; /evidence="ECO:0000269|PubMed:19837036
uniprot
proteins
protein_family
MPPE1 family
uniprot
proteins
protein_family
Metallophosphoesterase superfamily
uniprot
proteins
pubmed
11978971
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
19837036
uniprot
proteins
pubmed
29374258
uniprot
proteins
sequence_length
396
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:19837036}; Multi-pass membrane protein {ECO:0000255}. Note=Also localizes to endoplasmic reticulum exit site. {ECO:0000269|PubMed:19837036}.
uniprot
proteins
transmembrane_region
TRANSMEM 27..47; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 356..376; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins