Tshr
entrez
25360
canonical
uniprot
P21463
canonical
ensembl
ENSRNOG00000003972
resolver
ensp
ENSRNOP00000005671
resolver
enst
ENSRNOT00000005671
resolver
genesymbol
Tshr
resolver
genesymbol_syn
TSHR
resolver
uniprot
G3V6J1
resolver
uniprot_entry
G3V6J1_RAT
resolver
uniprot_entry
TSHR_RAT
resolver
amino_acid_sequence
MRPGSLLQLTLLLALPRSLWGRGCTSPPCECHQEDDFRVTCKELHQIPSLPPSTQTLKLIETHLKTIPSLAFSSLPNISRIYLSIDATLQRLEPHSFYNLSKMTHIEIRNTRSLTYIDPDALTELPLLKFLGIFNTGLRIFPDLTKIYSTDVFFILEITDNPYMTSVPENAFQGLCNETLTLKLYNNGFTSIQGHAFNGTKLDAVYLNKNKYLTAIDKDAFGGVYSGPTLLDVSSTSVTALPSKGLEHLKELIAKNTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNESSIRNLRQRKSVNVMRGPVYQEYEEGLGDNHVGYKQNSKFQEGPSNSHYYVFFEEQEDEIIGFGQELKNPQEETLQAFDSHYDYTVCGDNEDMVCTPKSDEFNPCEDIMGYKFLRIVVWFVSPMALLGNVFVLFVLLTSHYKLTVPRFLMCNLAFADFCMGVYLLLIASVDLYTHTEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHAYTIMAGGWVSCFLLALLPMVGISSYAKVSICLPMDTDTPLALAYIALVLLLNVVAFVIVCSCYVKIYITVRNPQYNPRDKDTKIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSGVLLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGLCKHQAQAYQAQRVCPNNNTGIQIQKIPQDTRQSLPNVQDTYEPLGSSHLTPKLQGRISEEYTQTAL
uniprot
proteins
function
FUNCTION: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin (PubMed:1696008). Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin (PubMed:12045258). TSHR is coupled to G(s) proteins and mediates the activation of adenylate cyclase. This leads to the generation of cyclic adenosine monophosphate (cAMP), which in turn activates protein kinase A (PKA). PKA subsequently phosphorylates downstream targets involved in thyroid hormone biosynthesis and secretion, including thyroid peroxidase (TPO) and the sodium/iodide symporter (NIS) (By similarity). Additionally, plays a central role in controlling thyroid cell metabolism (PubMed:12045258). {ECO:0000250|UniProtKB:P16473, ECO:0000269|PubMed:12045258, ECO:0000269|PubMed:1696008}.
uniprot
proteins
mass_dalton
86475
uniprot
proteins
mutagenesis
MUTAGEN 623; /note="A->E,K: Loss of TSH-increased inositol phosphate, but not cAMP formation."; /evidence="ECO:0000269|PubMed:1332945
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:P16473}.; PTM: Sulfated. Sulfation on Tyr-385 plays a role in thyrotropin receptor binding and activation. {ECO:0000250|UniProtKB:P16473}.
uniprot
proteins
protein_family
FSH/LSH/TSH subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12045258
uniprot
proteins
pubmed
1332945
uniprot
proteins
pubmed
1696008
uniprot
proteins
sequence_length
764
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P16473}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P16473}. Basolateral cell membrane {ECO:0000250|UniProtKB:P16473}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P16473}.
uniprot
proteins
transmembrane_region
TRANSMEM 415..440; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P16473"; TRANSMEM 451..473; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P16473"; TRANSMEM 493..517; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P16473"; TRANSMEM 538..558; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P16473"; TRANSMEM 577..602; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P16473"; TRANSMEM 626..649; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P16473"; TRANSMEM 658..681; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P16473
uniprot
proteins