Derl1
entrez
67819
canonical
uniprot
Q99J56
canonical
ensembl
ENSMUSG00000022365
resolver
ensp
ENSMUSP00000022993
resolver
enst
ENSMUST00000022993
resolver
genesymbol
Derl1
resolver
genesymbol_syn
Der1
resolver
uniprot
Q3U6Z2
resolver
uniprot
Q9D918
resolver
uniprot_entry
DERL1_MOUSE
resolver
uniprot_sec
Q3U6Z2
resolver
uniprot_sec
Q9D918
resolver
amino_acid_sequence
MSDIGDWFRSIPAITRYWFAATVAVPLIGKLGIISPAYFFLWPEAFLYRFQIWRPFTATFYFPVGPGTGFLYLVNLYFLYQYSTRLEAGAFDGRPADYLFMLLFNWICIVITGLAMDMQLLMIPLIMSVLYVWAQLNRDLIVSFWFGTRFKACYLPWVILGFNYIIGGSVINELIGNLVGHLYFFLMFRYPMDLGGRNFLSTPQFLYRWLPSRRGGVSGFGVPPASMRRAADQNGGGGRHNWGQGFRLGDQ
uniprot
proteins
function
FUNCTION: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. Forms homotetramers which encircle a large channel traversing the endoplasmic reticulum (ER) membrane. This allows the retrotranslocation of misfolded proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome. The channel has a lateral gate within the membrane which provides direct access to membrane proteins with no need to reenter the ER lumen first. May mediate the interaction between VCP and the misfolded protein. Also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. {ECO:0000250|UniProtKB:Q9BUN8}.
uniprot
proteins
mass_dalton
28835
uniprot
proteins
protein_family
Derlin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16186509
uniprot
proteins
pubmed
16449189
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22016385
uniprot
proteins
pubmed
22267725
uniprot
proteins
pubmed
24160817
uniprot
proteins
pubmed
25009997
uniprot
proteins
sequence_length
251
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9BUN8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9BUN8}.
uniprot
proteins
transmembrane_region
TRANSMEM 16..31; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q9BUN8"; TRANSMEM 70..89; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q9BUN8"; TRANSMEM 95..115; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q9BUN8"; TRANSMEM 123..137; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q9BUN8"; TRANSMEM 155..166; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q9BUN8"; TRANSMEM 171..189; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q9BUN8
uniprot
proteins