Atg5
entrez
365601
canonical
uniprot
Q3MQ06
canonical
ensembl
ENSRNOG00000000322
resolver
ensembl
ENSRNOG00055000734
resolver
ensembl
ENSRNOG00060006932
resolver
ensembl
ENSRNOG00065008666
resolver
ensp
ENSRNOP00000075339
resolver
ensp
ENSRNOP00000086278
resolver
ensp
ENSRNOP00000107876
resolver
ensp
ENSRNOP00055001018
resolver
ensp
ENSRNOP00060008481
resolver
ensp
ENSRNOP00065010208
resolver
enst
ENSRNOT00000080283
resolver
enst
ENSRNOT00000101057
resolver
enst
ENSRNOT00000133750
resolver
enst
ENSRNOT00055001267
resolver
enst
ENSRNOT00060011358
resolver
enst
ENSRNOT00065013759
resolver
genesymbol
Atg5
resolver
genesymbol_syn
LOC365601
resolver
uniprot
A0A8I6A5P8
resolver
uniprot
A0ABK0LUH8
resolver
uniprot
Q5XIS0
resolver
uniprot_entry
A0A8I6A5P8_RAT
resolver
uniprot_entry
A0ABK0LUH8_RAT
resolver
uniprot_entry
ATG5_RAT
resolver
uniprot_entry
Q5XIS0_RAT
resolver
amino_acid_sequence
MTDDKDVLRDVWFGRIPTCFTLYQDEITEREAEPYYLLLPRVSYLTLVTDKVKKHFQKVMRQEDVSEIWFEYEGTPLKWHYPIGLLFDLLASSSALPWNITVHFKSFPEKDLLHCPCKDAVEAHFMSCVKEADALKHKSQVINEMQRKDHKQLWMGLQNDRFDQFWTINRKLMEYPPEENGFRYIPFRIYQTTTERPFIQKLFRPVAADGQLHTLGDLLREVCPSAVAPEDGEKKSQVMIHGIEPLLETPLQWLSEHLSYPDNFLHISIVPQPTD
uniprot
proteins
function
FUNCTION: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. As part of the ATG8 conjugation system with ATG12 and ATG16L1, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress (By similarity). {ECO:0000250|UniProtKB:Q99J83, ECO:0000250|UniProtKB:Q9H1Y0}.; FUNCTION: May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD. {ECO:0000250|UniProtKB:Q9H1Y0}.
uniprot
proteins
mass_dalton
32398
uniprot
proteins
post_translational_modification
PTM: Conjugated to ATG12; which is essential for autophagy, but is not required for association with isolation membrane. {ECO:0000250}.; PTM: Acetylated by EP300. {ECO:0000250}.
uniprot
proteins
protein_family
ATG5 family
uniprot
proteins
sequence_length
275
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H1Y0}. Preautophagosomal structure membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. Also localizes to discrete punctae along the ciliary axoneme and to the base of the ciliary axoneme. Under starved conditions, the ATG12-ATG5-ATG16L1 complex is translocated to phagophores driven by RAB33B (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q9H1Y0}.
uniprot
proteins