Dact1
entrez
59036
canonical
uniprot
Q8R4A3
canonical
ensembl
ENSMUSG00000044548
resolver
ensp
ENSMUSP00000058943
resolver
ensp
ENSMUSP00000117169
resolver
enst
ENSMUST00000061273
resolver
enst
ENSMUST00000150639
resolver
genesymbol
Dact1
resolver
genesymbol_syn
Thyex3
resolver
uniprot
D3Z5V0
resolver
uniprot
Q80VG9
resolver
uniprot
Q8BP49
resolver
uniprot
Q9JK89
resolver
uniprot_entry
D3Z5V0_MOUSE
resolver
uniprot_entry
DACT1_MOUSE
resolver
uniprot_sec
Q80VG9
resolver
uniprot_sec
Q8BP49
resolver
uniprot_sec
Q9JK89
resolver
amino_acid_sequence
MKPDAAREPEPLSPGRGAEAEGRWRERGEADTERQRTRERQEATLAGLAELGYLRQRQELLVRGALRCSGTVGTVAPRSGELRGDAAQRSRLEEKFLEENILLLRRQLNCLRRRDAGLLNQLQELDKQISDLRLDVEKTSEEHLETDSRPSSGFYELSDGASGSLSNSSNSVFSECLSSCHSSTCFCSPLEAALTISDGCPKSADVNPKYQCDLVSKNGNDVYRYPSPLHAVAVQSPMFLLCLTGNTLREEEGLGSHASDICIGSELNATKTDNSLPSPSSLWSASHPASSKKMDGYILSLVQKKTHPVRTNKPRTSVNADPTKGLLRNGSVCVRAPSGVPPGSSVNFKNTKQMCLPAGGITSLENGPFSPPKQRSKDSKTDQLESKRLALPESCSAGAAMEPQSKHVPKAAKAASQELTRCQAGLGESMKESNQASAVSPKTSPGRGPVAPAESKALQLPKKMSQKNSLQAVPALDRPALDFKSEGSSQSLEEGHLVKAQFIPGQQAAARPHRAHRNPGVARSATLKARGQAAMEHGLPTVREKPRAAGKKCRFPDDSDTNKKFRKTSAKGRRSGGLQDAGLPGRALGTGGHRAGSRAHAHGREPVVAKPKHKRTDYRRWKSSAEVSYEEALRRARRARREHGAAYRVAVALPYASPYAYVPSDSEYSAECESLFHSTVVDTSEDEQSNYTTNCFGDSESSVSEGDFVGESTTTSDSEESGGLIWSQFVQTLPIQTVTAPDLHTRPTKTFVKIKASHNLKKKILRFRSGSLKLMTTV
uniprot
proteins
function
FUNCTION: Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome-dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB (By similarity). Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway. The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling (By similarity). May be involved in positive regulation of fat cell differentiation. During neuronal differentiation may be involved in excitatory synapse organization, and dendrite formation and establishment of spines. {ECO:0000250, ECO:0000269|PubMed:17197390, ECO:0000269|PubMed:19073771, ECO:0000269|PubMed:19701191, ECO:0000269|PubMed:20145239, ECO:0000269|PubMed:20335472}.
uniprot
proteins
mass_dalton
84306
uniprot
proteins
protein_family
Dapper family
uniprot
proteins
pubmed
11970895
uniprot
proteins
pubmed
14636582
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16278878
uniprot
proteins
pubmed
16881060
uniprot
proteins
pubmed
17197390
uniprot
proteins
pubmed
19073771
uniprot
proteins
pubmed
19701191
uniprot
proteins
pubmed
20145239
uniprot
proteins
pubmed
20335472
uniprot
proteins
pubmed
21718540
uniprot
proteins
sequence_length
778
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Synapse {ECO:0000269|PubMed:20335472}. Note=Shuttles between the nucleus and the cytoplasm. Seems to be nuclear in the absence of Wnt signaling and to translocate to the cytoplasm in its presence (By similarity). {ECO:0000250}.
uniprot
proteins