Arg1
entrez
29221
canonical
uniprot
P07824
canonical
ensembl
ENSRNOG00000013304
resolver
ensp
ENSRNOP00000017911
resolver
genesymbol
Arg1
resolver
uniprot
Q5BK93
resolver
uniprot_entry
ARGI1_RAT
resolver
uniprot_sec
Q5BK93
resolver
activity_regulation
ACTIVITY REGULATION: Inactivated by diethyl pyrocarbonate (DEPC).
uniprot
proteins
amino_acid_sequence
MSSKPKPIEIIGAPFSKGQPRGGVEKGPAALRKAGLVEKLKETEYNVRDHGDLAFVDVPNDSPFQIVKNPRSVGKANEQLAAVVAETQKNGTISVVLGGDHSMAIGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVAFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPVFTPATGTPVVGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTPEEVTRTVNTAVALTLSCFGTKREGNHKPETDYLKPPK
uniprot
proteins
ec_number
3.5.3.1
uniprot
proteins
function
FUNCTION: Catalyzes the final step of the urea cycle by hydrolyzing L-arginine into urea, a nitrogenous waste product, and L-ornithine, a precursor to proline and polyamines; the urea cycle occurs primarily in the liver and, to a lesser extent, in the kidneys. {ECO:0000305}.; FUNCTION: Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion (By similarity). In group 2 innate lymphoid cells (ILC2s) promotes acute type 2 inflammation in the lung and is involved in optimal ILC2 proliferation but not survival. Plays a role in the immune response of alternatively activated or M2 macrophages in processes such as wound healing and tissue regeneration, immune defense against multicellular pathogens and parasites, and immune suppression and allergic inflammation; the regulatory outcome seems to be organ specific. In tumor-infiltrating dendritic cells (DCs) and myeloid-derived suppressor cells (MDSCs) plays a role in suppression of T cell-mediated antitumor immunity. {ECO:0000250|UniProtKB:P05089, ECO:0000250|UniProtKB:Q61176}.
uniprot
proteins
mass_dalton
34973
uniprot
proteins
mutagenesis
MUTAGEN 101; /note="H->E: Reduced catalytic activity. No effect on manganese binding."; /evidence="ECO:0000269|PubMed:12820884"; MUTAGEN 128; /note="D->E,N: Reduced manganese binding and strongly reduced catalytic activity."; /evidence="ECO:0000269|PubMed:12820884"; MUTAGEN 141; /note="H->A,C,D: Strongly reduced catalytic activity. Minor effect on affinity for arginine."; /evidence="ECO:0000269|PubMed:16266687"; MUTAGEN 141; /note="H->N: Reduced affinity for arginine and reduced catalytic activity."; /evidence="ECO:0000269|PubMed:16266687"; MUTAGEN 232; /note="D->A: Loss of one manganese ion and strongly reduced catalytic activity."; /evidence="ECO:0000269|PubMed:12820884"; MUTAGEN 232; /note="D->C: Reduced manganese binding and strongly reduced catalytic activity."; /evidence="ECO:0000269|PubMed:12820884"; MUTAGEN 234; /note="D->A,E,H: Reduced manganese binding and strongly reduced catalytic activity."; /evidence="ECO:0000269|PubMed:12820884"; MUTAGEN 235; /note="G->A: 56% of wild-type activity."; /evidence="ECO:0000269|PubMed:11883902"; MUTAGEN 235; /note="G->R: Loss of manganese-binding and activity."; /evidence="ECO:0000269|PubMed:11883902
uniprot
proteins
pathway_participation
PATHWAY: Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1. {ECO:0000250|UniProtKB:P05089}.
uniprot
proteins
protein_family
Arginase family
uniprot
proteins
pubmed
10542097
uniprot
proteins
pubmed
11258880
uniprot
proteins
pubmed
11883902
uniprot
proteins
pubmed
12820884
uniprot
proteins
pubmed
15248756
uniprot
proteins
pubmed
15315440
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16266687
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2892837
uniprot
proteins
pubmed
3571256
uniprot
proteins
pubmed
8849731
uniprot
proteins
pubmed
9265637
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P05089}. Cytoplasmic granule {ECO:0000250|UniProtKB:P05089}. Note=Localized in azurophil granules of neutrophils. {ECO:0000250|UniProtKB:P05089}.
uniprot
proteins