Gpr179
entrez
217143
canonical
uniprot
E9PY61
canonical
ensembl
ENSMUSG00000070337
resolver
ensp
ENSMUSP00000091474
resolver
enst
ENSMUST00000093942
resolver
genesymbol
Gpr179
resolver
genesymbol_syn
Nob5
resolver
uniprot_entry
GP179_MOUSE
resolver
amino_acid_sequence
MGARAVVISSLAWGLLSCCFLCSGALGSQRPLRSLPPLPSQAKPRSEPMWMPPKGAEAALAFLYSGDVQRLSGANCSEKYEVRGAEGKAGVPPVLQRAAGTLAQAANFLNMLLQANDIRESSVEEDVEWYQALVRSVAEGDPKAYRALLTFNPAPGASHLQLALQATRMGDETVLQDLSGNKVQEETPGEDLDRPVLQKRVLTNDLRSLDSPKWPRGDGYVGDIQQVKLSPPFLECHEGQLRPGWLVTVSATFYGLKPDLTPEVRGQVQMDIDLQSVDINQCASGPGWYSNTHLCDLNSTQCVPLESQGFVLGRYLCRCRPGFYGASGSGGLEESATQAAGQFGSPQDSLGKLLRCQPCPEGCTSCLDATPCLVEEALALRTAVLACQACCMLAVFLSMLVAYRCRGSKRIRASGIVLLETILFGSLLLYFPVFILYFKPSVFRCVALRWVRLLGFAVVYGTIILKLYRVLQLFLSRTAQRVPHPSSGQLLRRLGQLLLLVLGFLVVWTAGALEPGTQHTALVTRGHTPTGRHFYLCHHDHWDYIMVVAEMLLLCWGSFLCYATRAVPSAFHEPRYMSIALHNELLLSTAFHTARFVLVPSLHPDWTLLLFFLHTHSTVTATLALIFIPKFWKPGAPPREEILDEVYEDELDLQRSGSYLNSSIASAWSERSLEPGDIRDELKKLYAQLEIRKTKEMAANNPHLPKKRGSSHQGLGRSFMRYLAEFPEALARQHSRDSGSLGLGSLPGSSRRRLLSSSLQETEKPPALRKTRSTYDHHREHNTLPFDSTLRRTLSKKASPTDGRESLADGPPALGFRSASAHNLTVGERLPRARPISLQKSLSVAAGSREKALLVASQAYLEETYRQAKEREERKKAEAAMVSPVRRPSTRRLEWPLRAPLSAPPSPGKSSSMDSSQTTARPHEEAGRRLPHPPIRHQVSTPVLALSGICLGEPRMLSPTPASTLAPILLPAPAPAPAPVLAPVSKPPQSPTLLTFICPWENAELPGKKENVVQEDPAGPERSGHSPASARTKIWRALSVAVEKRGTGESEALTEGGHVQGEADDTDEEKPKVFSKSHSLKTPLQQGSVRSLGLAIKALTRSRSTYKEKDGGEGTPETEKGKPTEVSTGAPLRSPRLGRPKAVSKQVALAPCEDEESLQNQQNAHTSRMLHVCQKEGSREQEDRNKRVAPGPGERKVERTGKITMTTLRQVFGEKNAEQAKESPAGYQEVPNPALQSLGSADHRVAEVCPWEVTEPESGMDPPESVNKAKVYSWERTEGGSLEKKPSRQVLSRSWEEREKVLAESETEGVGAIPRKKPERLVRSQEAVCPWESPDSGGLSPQLVHQESDRTGGRFVVVSKGDAHPEALPSHAAKAELCLWEMSDVGEGTSTQRVQELPEERQKSPKKATFWGERNLGGDLVSLCPWESTDFRGPSAVSLQAPGSSGSLGSGIAEVCPWEAENIANDKKAEVCPWELGEELAGSDGLNPGADGKSLPGKETPSRKGCLAESGEQTVRAKPTVPQGQESVCPWEDEAPERSSPQPDKASSKAGEKLLSHGGSQVLQVCPWEAVKPEEKQATLSTAEICPWEVDGQPETRTSEHPSKGEVHKDEEKMPGRARIKAQEEAEGRIQKQEAICPWESMAPGSTPQRDTEKAQASLQRQGSVAGRAAEICPWEVGTEVGEERTIGAEASEARPNDAGHASTDSGSRQVAASAPKKSERLGSEKEVVCPWDSLSPGDSSQQPDTPNTEKLKDELQEHGSSRPIEVCPWEAEEVPTGEKAKICPWELNEGTVGKGLEREPGCEPERQRRQNLEEAGLPFQEEGTSKGDTKLCREQEGEAICPWKPPAQVPKVSDLPLSTVGQGVEGQSLEASDRASEKGELRQDLKMGSLPEYITQVVPVDGGGASSELQPISLQEGMVLAGSSSHPHIQCPDQPRVSSQPLVSTGDGTAEVCPWDAPDSDSDTKVEPCAQKVTGRVTETEMSRQDEKEKSQEEKERAPETRDHEGVAVQKMPQTSNFGKQEAVCPRESQDFGVQAATDASDGSKGGSEKVCPWEVEEVPSIKEAEICPWEASPGAVGEGALDLGQDGESQGEGRAERHLLKAAETVCPLEGTMSSGLFTQEDVVDTDLPKVGLHGASSPGKGLAELCVWEVTDPEGNKIKGTMADICPWEETRAQSDESGPLALPVTQAGVPAAPEKSVCLSVHGPLESFLPESKSVRPDISKPPGSSRPEGVREQEPLELETGAKSVPKPSPTETEAPESFTLTDDQGLMASEGEAGELSPPPDYPWDCE
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Gpr179 are the cause of nob5 (no b-wave 5), a spontaneous mutation that causes failure to transmit the photoreceptor signal through the depolarizing bipolar cells, characterized by an absence of the electroretinogram (ERG) b-wave (PubMed:22325362, PubMed:24084093, PubMed:24415894). In retina, rod and cone ON-bipolar cell function is absent (PubMed:22325362). {ECO:0000269|PubMed:22325362, ECO:0000269|PubMed:24084093, ECO:0000269|PubMed:24415894}.; DISEASE: Note=Defects in Pde6b are involved in the retinal degeneration 1 (rd1) allele, which causes retinal degeneration (PubMed:25613321). The rd1 allele is mainly caused by defects in the Pde6b gene, but it contains a cofounding mutation in the Gpr179 gene (PubMed:25613321). {ECO:0000269|PubMed:25613321}.
uniprot
proteins
function
FUNCTION: Orphan receptor involved in vision (PubMed:22325362, PubMed:24114537, PubMed:24790204, PubMed:30282023). Required for signal transduction through retinal depolarizing bipolar cells (PubMed:22325362, PubMed:24114537, PubMed:24790204, PubMed:33922602). Acts as an atypical G protein-coupled receptor that recruits and regulates the R7 group RGS-GNB5 complexes instead of activating G proteins: promotes the GTPase activator activity of R7 RGS proteins, increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:22689652, PubMed:24790204). Associates with components of metabotropic signaling cascade in retina ON-bipolar neurons, such as TRPM1 and GRM6: may control the ability of the GRM6 cascade to gate TRPM1 (PubMed:24114537, PubMed:24790204). {ECO:0000269|PubMed:22325362, ECO:0000269|PubMed:22689652, ECO:0000269|PubMed:24114537, ECO:0000269|PubMed:24790204, ECO:0000269|PubMed:30282023, ECO:0000269|PubMed:33922602}.
uniprot
proteins
mass_dalton
248715
uniprot
proteins
protein_family
G protein-coupled receptor 3 family
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22325362
uniprot
proteins
pubmed
22689652
uniprot
proteins
pubmed
24084093
uniprot
proteins
pubmed
24114537
uniprot
proteins
pubmed
24415894
uniprot
proteins
pubmed
24790204
uniprot
proteins
pubmed
25613321
uniprot
proteins
pubmed
30282023
uniprot
proteins
pubmed
33922602
uniprot
proteins
pubmed
34333057
uniprot
proteins
pubmed
36613663
uniprot
proteins
sequence_length
2293
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22689652}; Multi-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane {ECO:0000269|PubMed:24114537}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000269|PubMed:22325362, ECO:0000269|PubMed:24114537, ECO:0000269|PubMed:24790204}. Note=Specifically localizes to the tips of retinal ON-bipolar dendrites. {ECO:0000269|PubMed:22325362, ECO:0000269|PubMed:24790204}.
uniprot
proteins
transmembrane_region
TRANSMEM 383..403; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 416..436; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 445..465; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 494..514; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 544..564; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 585..602; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 608..628; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins