Camk2n1
entrez
66259
canonical
uniprot
Q6QWF9
canonical
ensembl
ENSMUSG00000046447
resolver
ensp
ENSMUSP00000060349
resolver
enst
ENSMUST00000050918
resolver
genesymbol
Camk2n1
resolver
uniprot_entry
CK2N1_MOUSE
resolver
amino_acid_sequence
MSEVLPYGDEKLSPYGDGGDVGQIFSCRLQDTNNFFGAGQSKRPPKLGQIGRSKRVVIEDDRIDDVLKTMTDKAPPGV
uniprot
proteins
function
FUNCTION: Potent and specific inhibitor of CaM-kinase II (CAMK2) (By similarity). Plays a role in the maintenance of long-term retrieval-induced memory in response to contextual fear (PubMed:28642476). Modulates blood pressure and vascular reactivity via regulation of CAMK2 activity in addition to regulation of left ventricular mass (By similarity). Mediates the NLRP3 inflammasome in cardiomyocytes via acting as an inhibitor of the MAPK14/p38 and MAPK8/JNK pathways, thereby regulating ventricular remodeling and cardiac rhythm post-myocardial infarction (PubMed:33746041). Negatively effects insulin sensitivity and promotes lipid formation in adipose tissues independent of CAMK2 signaling (PubMed:31327268). {ECO:0000250|UniProtKB:Q9JI15, ECO:0000269|PubMed:28642476, ECO:0000269|PubMed:31327268, ECO:0000269|PubMed:33746041}.
uniprot
proteins
mass_dalton
8513
uniprot
proteins
protein_family
CAMK2N family
uniprot
proteins
pubmed
16819996
uniprot
proteins
pubmed
17010311
uniprot
proteins
pubmed
17350603
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28642476
uniprot
proteins
pubmed
31327268
uniprot
proteins
pubmed
33746041
uniprot
proteins
sequence_length
78
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Synapse {ECO:0000269|PubMed:17350603, ECO:0000269|PubMed:28642476}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9JI15}. Postsynaptic density {ECO:0000269|PubMed:17350603}.
uniprot
proteins