Slc26a8
entrez
224661
canonical
uniprot
Q8R0C3
canonical
ensembl
ENSMUSG00000036196
resolver
ensp
ENSMUSP00000110412
resolver
ensp
ENSMUSP00000178510
resolver
genesymbol
Slc26a8
resolver
genesymbol_syn
Tat1
resolver
uniprot_entry
S26A8_MOUSE
resolver
amino_acid_sequence
MQTERSLQSFSNRYTQIPFVYDVKRSVYNEENFQQEHRKKGPTSGNVDIDITTFKHHVQCGCSWHKFLRCMLTVFPFLEWICLYRFKDWLLGDLLAGLSVGLVQVPQGLILSLLTRQLIPPLNVTYAAFCSSVIYVIFGSCHQMSIGPFFLVSALMINVLKDRPFNNGHLILGTFVKDDFSVPTFYLSYNRSLSMVASTTFLTGIIQLSMGMLGMGFMATYLPEAATSAYLAAVALHIILAQMTCILGIMVSFHAGPISFIYNIINYCIALPKANSTSILLFITSVVALRINKCIRITFNRYPIEFPMELLLILGFSLLTSKITMATENSKMLMNMIPYSFVFPENPEFGILSRVVLQALSLSFVSSFLLISLGKKIANFHNYRTNSNQDLIAIGLCNLLSSFFKCCVFTGSLSRTTIQDKSGGRQQFASLVGAGVMLLLMVKMESFFHNLPNAVLAGIILSNVVPYLEAIYNLPSLWRQDQYECIIWMVTFSSAILLGLDVGLLISLAFTFFVITIRSHRTKILVLGQIPNTNIYRNVNDYREVILIPGVKIFQCCSSITFVNVYHLKQKVLKEVNMVKLPLKEEEIYTLFHESETSIAENKLCRCFCDCEELEPEIRVVYTERYENRQEQDSSINLIRCSYLGSGDSSQVTSEEQIPYTVSSTSQRNIVQSYEDTEKAWLPNSPPRNSPLPPPEASESLAQSRSRSIIMPYSDTSVQNNTHTIILDFSMVHYVDNRALVILRQMCNAFYNANILVLISGCHTSVVKSFEKNDFFDEGITKAQLFLSLHDAVLFALSRKFSEPSDLSMDETETVIQETYSESDKNGNLSNLRLKTGKAIIEGSQHASPGFTKNLKPGKDDLEFDLELDPMLSFEQSSGMDLNLDLDLDLDQSELDPGSELDSEIQAKPELELESELETDAQTEPETEEEPELEPEPEPEPETEPEPEPERERKTRTRSQSPWRNYFTAYRFGSSNSQSRAPPQTRPEKRKPHNYPNSP
uniprot
proteins
function
FUNCTION: Antiporter that mediates the exchange of sulfate and oxalate against chloride ions across a membrane. Stimulates anion transport activity of CFTR (By similarity). May cooperate with CFTR in the regulation of chloride and bicarbonate ions fluxes required for activation of the ADCY10/PKA pathway during sperm motility and sperm capacitation (PubMed:22121115). May play a role in sperm tail differentiation and motility and hence male fertility (PubMed:17517695). {ECO:0000250|UniProtKB:Q96RN1, ECO:0000269|PubMed:17517695, ECO:0000269|PubMed:22121115}.
uniprot
proteins
mass_dalton
112978
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q96RN1}.
uniprot
proteins
protein_family
SLC26A/SulP transporter (TC 2.A.53) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17517695
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22121115
uniprot
proteins
sequence_length
999
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:17517695}; Multi-pass membrane protein {ECO:0000255}. Note=Located at the annulus ring structure within the sperm cell. {ECO:0000269|PubMed:17517695}.
uniprot
proteins
transmembrane_region
TRANSMEM 94..114; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 118..138; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 140..160; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 201..221; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 231..251; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 269..289; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 306..326; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 355..375; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 391..411; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 428..448; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 454..474; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 495..515; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 545..565; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins