NAA15
entrez
80155
canonical
uniprot
Q9BXJ9
canonical
ensembl
ENSG00000164134
resolver
ensp
ENSP00000296543
resolver
ensp
ENSP00000381920
resolver
enst
ENST00000398947
resolver
genesymbol
NAA15
resolver
genesymbol_syn
GA19
resolver
genesymbol_syn
NARG1
resolver
genesymbol_syn
NATH
resolver
genesymbol_syn
TBDN100
resolver
hgnc
HGNC:30782
resolver
uniprot
A0A0B4J1W3
resolver
uniprot
B2RBE5
resolver
uniprot
D3DNY6
resolver
uniprot
Q52LG9
resolver
uniprot
Q8IWH4
resolver
uniprot
Q8NEV2
resolver
uniprot
Q9H8P6
resolver
uniprot_entry
A0A0B4J1W3_HUMAN
resolver
uniprot_entry
B2RBE5_HUMAN
resolver
uniprot_entry
NAA15_HUMAN
resolver
uniprot_sec
D3DNY6
resolver
uniprot_sec
Q52LG9
resolver
uniprot_sec
Q8IWH4
resolver
uniprot_sec
Q8NEV2
resolver
uniprot_sec
Q9H8P6
resolver
amino_acid_sequence
MPAVSLPPKENALFKRILRCYEHKQYRNGLKFCKQILSNPKFAEHGETLAMKGLTLNCLGKKEEAYELVRRGLRNDLKSHVCWHVYGLLQRSDKKYDEAIKCYRNALKWDKDNLQILRDLSLLQIQMRDLEGYRETRYQLLQLRPAQRASWIGYAIAYHLLEDYEMAAKILEEFRKTQQTSPDKVDYEYSELLLYQNQVLREAGLYREALEHLCTYEKQICDKLAVEETKGELLLQLCRLEDAADVYRGLQERNPENWAYYKGLEKALKPANMLERLKIYEEAWTKYPRGLVPRRLPLNFLSGEKFKECLDKFLRMNFSKGCPPVFNTLRSLYKDKEKVAIIEELVVGYETSLKSCRLFNPNDDGKEEPPTTLLWVQYYLAQHYDKIGQPSIALEYINTAIESTPTLIELFLVKAKIYKHAGNIKEAARWMDEAQALDTADRFINSKCAKYMLKANLIKEAEEMCSKFTREGTSAVENLNEMQCMWFQTECAQAYKAMNKFGEALKKCHEIERHFIEITDDQFDFHTYCMRKITLRSYVDLLKLEDVLRQHPFYFKAARIAIEIYLKLHDNPLTDENKEHEADTANMSDKELKKLRNKQRRAQKKAQIEEEKKNAEKEKQQRNQKKKKDDDDEEIGGPKEELIPEKLAKVETPLEEAIKFLTPLKNLVKNKIETHLFAFEIYFRKEKFLLMLQSVKRAFAIDSSHPWLHECMIRLFNTAVCESKDLSDTVRTVLKQEMNRLFGATNPKNFNETFLKRNSDSLPHRLSAAKMVYYLDPSSQKRAIELATTLDESLTNRNLQTCMEVLEALYDGSLGDCKEAAEIYRANCHKLFPYALAFMPPGYEEDMKITVNGDSSAEAEELANEI
uniprot
proteins
disease_involvement
DISEASE: Intellectual developmental disorder, autosomal dominant 50, with behavioral abnormalities (MRD50) [MIM:617787]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. {ECO:0000269|PubMed:28191889}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Auxillary subunit of N-terminal acetyltransferase complexes which display alpha (N-terminal) acetyltransferase (NAT) activity (PubMed:15496142, PubMed:20154145, PubMed:29754825, PubMed:32042062). The NAT activity may be important for vascular, hematopoietic and neuronal growth and development (PubMed:15496142). Required to control retinal neovascularization in adult ocular endothelial cells (PubMed:11687548). In complex with XRCC6 and XRCC5 (Ku80), up-regulates transcription from the osteocalcin promoter (PubMed:12145306). {ECO:0000269|PubMed:11687548, ECO:0000269|PubMed:12145306, ECO:0000269|PubMed:15496142, ECO:0000269|PubMed:20154145, ECO:0000269|PubMed:29754825, ECO:0000269|PubMed:32042062}.
uniprot
proteins
mass_dalton
101272
uniprot
proteins
mutagenesis
MUTAGEN 406; /note="T->Y: Reduces binding to NAA50, but increases binding to HYPK. Reduces catalytic activity of the NatA complex while retaining the interaction with NAA10."; /evidence="ECO:0000269|PubMed:32042062"; MUTAGEN 814; /note="L->P: Reduces binding to HYPK, increases binding to NAA50. Increases catalytic activity of the NatA complex while retaining the interaction with NAA10."; /evidence="ECO:0000269|PubMed:32042062"; MUTAGEN 834; /note="Y->F,A: Reduces NatA complex stability and reduces catalytic activity."; /evidence="ECO:0000269|PubMed:29754825
uniprot
proteins
post_translational_modification
PTM: Cleaved by caspases during apoptosis, resulting in a stable 35 kDa fragment.
uniprot
proteins
pubmed
11687548
uniprot
proteins
pubmed
12019451
uniprot
proteins
pubmed
12087473
uniprot
proteins
pubmed
12140756
uniprot
proteins
pubmed
12145306
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15496142
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16507339
uniprot
proteins
pubmed
16638120
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19660095
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20154145
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28191889
uniprot
proteins
pubmed
29754825
uniprot
proteins
pubmed
32042062
uniprot
proteins
sequence_length
866
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Mainly cytoplasmic, nuclear in some cases. Present in the free cytosolic and cytoskeleton-bound polysomes, but not in the membrane-bound polysomes.
uniprot
proteins