Spi1
entrez
366126
canonical
uniprot
Q6BDS1
canonical
ensembl
ENSRNOG00000012172
resolver
ensp
ENSRNOP00000016306
resolver
ensp
ENSRNOP00000108151
resolver
enst
ENSRNOT00000142253
resolver
genesymbol
Spi1
resolver
genesymbol_syn
Sfpi1
resolver
uniprot
Q5BK69
resolver
uniprot_entry
SPI1_RAT
resolver
uniprot_sec
Q5BK69
resolver
activity_regulation
ACTIVITY REGULATION: Transcriptional activity at macrophage-specific genes is inhibited by interaction with GFI1, which results in the inhibition of SPI1-induced macrophage differentiation of myeloid progenitor cells, but not that of the granulocyte lineage. {ECO:0000250|UniProtKB:P17433}.
uniprot
proteins
amino_acid_sequence
MLQACKMEGFPLVAPPSDELVTYESELYQRQTHDYYSLIGGDGDSHSDHYWDFSTHHVHSEFESFPENHFTELQSVQPPQLQQLYRHMELEQMHVLDTPMAPPHASLSHQVSYMPRVCFPYPPLSPAHQQSSDEEEGERQSPPLEVSDGEADGLEPGPGLLHGETGSKKKIRLYQFLLDLLRSGDMKDSIWWVDKDKGTFQFSSKHKEALAHRWGIQKGNRKKMTYQKMARALRNYGKTGEVKKVKKKLTYQFSGEVLGRGGLAERRLPPH
uniprot
proteins
function
FUNCTION: Pioneer transcription factor, which controls hematopoietic cell fate by decompacting stem cell heterochromatin and allowing other transcription factors to enter otherwise inaccessible genomic sites. Once in open chromatin, can directly control gene expression by binding genetic regulatory elements and can also more broadly influence transcription by recruiting transcription factors, such as interferon regulatory factors (IRFs), to otherwise inaccessible genomic regions (By similarity). Transcriptionally activates genes important for myeloid and lymphoid lineages, such as CSF1R or FCER1A (PubMed:15304324). Transcriptional activation from certain promoters, possibly containing low affinity binding sites, is achieved cooperatively with other transcription factors. FCER1A transactivation is achieved in cooperation with GATA1 (PubMed:15304324). May be particularly important for the pro- to pre-B cell transition. Binds (via the ETS domain) onto the purine-rich DNA core sequence 5'-GAGGAA-3', also known as the PU-box (By similarity). In vitro can bind RNA and interfere with pre-mRNA splicing (By similarity). {ECO:0000250|UniProtKB:P17433, ECO:0000250|UniProtKB:P17947, ECO:0000269|PubMed:15304324}.
uniprot
proteins
mass_dalton
31089
uniprot
proteins
mutagenesis
MUTAGEN 41; /note="G->A,S: No effect on transcriptional activation of CSF1R or FCER1A promoter."; /evidence="ECO:0000269|PubMed:15304324"; MUTAGEN 45; /note="S->A: No effect on transcriptional activation of CSF1R or FCER1A promoter."; /evidence="ECO:0000269|PubMed:15304324
uniprot
proteins
protein_family
ETS family
uniprot
proteins
pubmed
15304324
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
271
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237}.
uniprot
proteins