Capn2
entrez
12334
canonical
uniprot
O08529
canonical
ensembl
ENSMUSG00000026509
resolver
ensp
ENSMUSP00000068895
resolver
enst
ENSMUST00000068505
resolver
genesymbol
Capn2
resolver
uniprot
O35518
resolver
uniprot
O54843
resolver
uniprot_entry
CAN2_MOUSE
resolver
uniprot_sec
O35518
resolver
uniprot_sec
O54843
resolver
activity_regulation
ACTIVITY REGULATION: Activated by 200-1000 micromolar concentrations of calcium and inhibited by calpastatin.
uniprot
proteins
amino_acid_sequence
MAGIAIKLAKDREAAEGLGSHERAIKYLNQDYETLRNECLEAGALFQDPSFPALPSSLGYKELGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPPDQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELRKPPPNLFKIIQKALEKGSLLGCSIDITSAADSEAVTYQKLVKGHAYSVTGAEEVESSGSLQKLIRIRNPWGQVEWTGKWNDNCPSWNTVDPEVRANLTERQEDGEFWMSFSDFLRHYSRLEICNLTPDTLTCDSYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDEEDGERGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELTGQTNIHLGKNFFLTTRARERSDTFINLREVLNRFKLPPGEYVLVPSTFEPHKDGDFCIRVFSEKKADYQAVDDEIEANIEEIDANEEDIDDGFRRLFVQLAGEDAEISAFELQTILRRVLAKRQDIKSDGFSIETCKIMVDMLDEDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKLPCQLHQVIVARFADDELIIDFDNFVRCLVRLETLFKIFKQLDPENTGTIQLNLASWLSFSVL
uniprot
proteins
ec_number
3.4.22.53
uniprot
proteins
function
FUNCTION: Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (By similarity). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs (PubMed:22711986). {ECO:0000250|UniProtKB:P17655, ECO:0000269|PubMed:22711986}.
uniprot
proteins
mass_dalton
79872
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated via 'Lys6'-linked chains by the E3 ubiquitin ligase complex at least composed of CUL3, KCTD7 and RBX1 to execute atypical, non-degradative ubiquitination. {ECO:0000250|UniProtKB:P17655}.
uniprot
proteins
protein_family
Peptidase C2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22711986
uniprot
proteins
pubmed
9339374
uniprot
proteins
pubmed
9669314
uniprot
proteins
sequence_length
700
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocates to the plasma membrane upon Ca(2+) binding. {ECO:0000250}.
uniprot
proteins