Prepl
entrez
213760
canonical
uniprot
Q8C167
canonical
ensembl
ENSMUSG00000024127
resolver
ensp
ENSMUSP00000072239
resolver
ensp
ENSMUSP00000130967
resolver
genesymbol
Prepl
resolver
genesymbol_syn
Kiaa0436
resolver
uniprot
Q3TR35
resolver
uniprot
Q6ZQB4
resolver
uniprot
Q8BKS6
resolver
uniprot
Q8BUP5
resolver
uniprot
Q99KJ9
resolver
uniprot_entry
PPCEL_MOUSE
resolver
uniprot_entry
Q8BKS6_MOUSE
resolver
uniprot_sec
Q3TR35
resolver
uniprot_sec
Q6ZQB4
resolver
uniprot_sec
Q8BUP5
resolver
uniprot_sec
Q99KJ9
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by 1-isobutyl-3-oxo-3,5,6,7-tetrahydro-2H-cyclopenta[c]pyridine-4-carbonitrile. {ECO:0000269|PubMed:21692504}.
uniprot
proteins
amino_acid_sequence
MLQTAKFSLRALKHSIPHLGNCMQKQSYRNVAGPYYSRVRLKKYHLTKCLQNKPRIAGLARNIPSRSFSCKDLLPIKPESEKPISENMDAFEKVRTRLETQPQEEYEVVNAEIKHGGFVYYQEGCCLVRSKDEEADSDNYEVLFNLEELKLDQPFIDCIRVAPDEKYVAAKIRTEDSETSTLVVVKLSDQPVMEASFPNVSSFEWVKDEEDEDVLFYTFQRNLRCHDVYRATFGDNKRNERFYTEKDPSYFVFLYLTKDSRFLTLNIMNKTTSEVWLIDGLSPWDPPVLIQKRIHGMLYYVEHRDDELYILTNVGEPTEFKLMRTAADAPAIMNWDLFFTMKRNTKVVDLDMFKDHCVLFLKHSNLLYVNVIGLADDSVRSLKLPPWACGFIMDTNSDPKNCPFQLCSPIRPPKYYTYKFAEGKLFEETGHEDPITKTSRVLRIEAKSKDGKLVPMTVFHKTDSEDLQRKPLLVHVYGAYGMDLKMNFRPEKRVLVDDGWILAYCHVRGGGELGLQWHADGRLTKKLNGLADLVACIKTLHSQGFSQPSLTTLSAFSAGGVLVGALCNSKPELLRAVTLEAPFLDVLNTMLDTTLPLTLEELEEWGNPSSDEKHKNYIKRYCPCQNIKPQHYPSVHITAYENDERVPLKGIVNYTEKLKEAVAEHTKGAGEGYQPPNIILDIQPGGNHVIEDSHKKITTQMKFLYEELGLDSTDAFEALKKYLKF
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Serine peptidase whose precise substrate specificity remains unclear (PubMed:21692504). Does not cleave peptides after a arginine or lysine residue (By similarity). Regulates trans-Golgi network morphology and sorting by regulating the membrane binding of the AP-1 complex (PubMed:23321636). May play a role in the regulation of synaptic vesicle exocytosis (By similarity). {ECO:0000250|UniProtKB:Q4J6C6, ECO:0000269|PubMed:21692504, ECO:0000269|PubMed:23321636}.
uniprot
proteins
mass_dalton
83194
uniprot
proteins
mutagenesis
MUTAGEN 557; /note="S->A: Loss of catalytic activity. No effect on the redistribution of AP-1 from the membrane to the cytoplasm."; /evidence="ECO:0000269|PubMed:21692504, ECO:0000269|PubMed:23321636
uniprot
proteins
protein_family
Peptidase S9A family
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21692504
uniprot
proteins
pubmed
23321636
uniprot
proteins
pubmed
23485813
uniprot
proteins
pubmed
24586561
uniprot
proteins
sequence_length
725
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:23321636, ECO:0000269|PubMed:23485813}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:23321636}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23485813}. Golgi apparatus {ECO:0000269|PubMed:23485813}. Nucleus {ECO:0000250|UniProtKB:Q4J6C6}. Note=Co-localizes with AP-1 in the trans-Golgi network (PubMed:23321636). Co-localizes with MAP2 and ACTB on the cytoskeleton (PubMed:23485813). Co-localizes with STX6 and GOSR2 at the Golgi apparatus (PubMed:23485813). {ECO:0000269|PubMed:23321636, ECO:0000269|PubMed:23485813}.
uniprot
proteins