Ttll9
entrez
74711
canonical
uniprot
A2APC3
canonical
ensembl
ENSMUSG00000074673
resolver
ensp
ENSMUSP00000096803
resolver
ensp
ENSMUSP00000099444
resolver
ensp
ENSMUSP00000238891
resolver
genesymbol
Ttll9
resolver
uniprot
A2APC4
resolver
uniprot
A2APC5
resolver
uniprot
A2APC6
resolver
uniprot
Q9D570
resolver
uniprot_entry
TTLL9_MOUSE
resolver
uniprot_sec
A2APC4
resolver
uniprot_sec
A2APC5
resolver
uniprot_sec
A2APC6
resolver
uniprot_sec
Q9D570
resolver
amino_acid_sequence
MSRQKNQNSKGHGVSKGKEREQRTLIRFKTTLMNTLMDVLRHRPGWVEVKDEGEWDFYWCDVSWLRENFDHTYMDEHVRISHFRNHYELTRKNYMVKNLKRFRKYLERESGKTEAAKCDFFPKTFEMPCEYHLFVEEFRKNPGITWIMKPVARSQGKGIFLFRRLKDIMDWRKGTSGKKPTGVETQPARANMNPSGSHDTRSSDDQKDDLPVENYVAQRYVENPYLIGGRKFDLRVYVLVMSYIPLRAWLYRDGFARFSNTRFTLNSIDDHYVHLTNVAVQKTSPDYHLKKGCKWMLQRFRQYLASKHGPKAVETLFSDMDNIFIKSLQSVQKVIISDKHCFELYGYDILIDQDLKPWLLEVNASPSLTASSQEDYELKTCLLEDTLHVVDMEARLTGKEKRVGGFDLMWNDGPVSREDGPSDLSGMGNFVTNTHLGCVNDRKEQLRQLFRSLQAQRKAPS
uniprot
proteins
ec_number
6.3.2.-
uniprot
proteins
function
FUNCTION: Probable tubulin polyglutamylase that generates side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of target proteins (PubMed:27257088). Similar to TTLL1, may acquire enzymatic activity only in complex with other proteins as it is most likely lacking domains important for autonomous activity (Probable). Mediates tubulin polyglutamylation which induces establishment of microtubule heterogeneity in sperm flagella, thereby playing a role in normal motile flagella axoneme structure and sperm flagella beating pattern (PubMed:27257088). {ECO:0000269|PubMed:27257088, ECO:0000305|PubMed:17499049}.
uniprot
proteins
mass_dalton
54107
uniprot
proteins
protein_family
Tubulin--tyrosine ligase family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17499049
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23897886
uniprot
proteins
pubmed
27257088
uniprot
proteins
sequence_length
461
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:17499049}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17499049}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000305|PubMed:27257088}.
uniprot
proteins