PIM2
entrez
11040
canonical
uniprot
Q9P1W9
canonical
ensembl
ENSG00000102096
resolver
ensembl
ENSG00000292210
resolver
ensp
ENSP00000365692
resolver
ensp
ENSP00000518036
resolver
enst
ENST00000376509
resolver
enst
ENST00000710069
resolver
genesymbol
PIM2
resolver
hgnc
HGNC:8987
resolver
uniprot
A8K4G6
resolver
uniprot
Q99739
resolver
uniprot_entry
PIM2_HUMAN
resolver
uniprot_sec
A8K4G6
resolver
uniprot_sec
Q99739
resolver
amino_acid_sequence
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate. {ECO:0000269|PubMed:18593906, ECO:0000269|PubMed:18675992, ECO:0000269|PubMed:20307683}.
uniprot
proteins
mass_dalton
34190
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. {ECO:0000250}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
PIM subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
16548883
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18593906
uniprot
proteins
pubmed
18675992
uniprot
proteins
pubmed
19841674
uniprot
proteins
pubmed
20307683
uniprot
proteins
pubmed
9804974
uniprot
proteins
sequence_length
311
uniprot
proteins