Tmem63c
entrez
217733
canonical
uniprot
Q8CBX0
canonical
ensembl
ENSMUSG00000034145
resolver
ensp
ENSMUSP00000105816
resolver
ensp
ENSMUSP00000117023
resolver
ensp
ENSMUSP00000119872
resolver
ensp
ENSMUSP00000303918
resolver
ensp
ENSMUSP00000303920
resolver
ensp
ENSMUSP00000303921
resolver
enst
ENSMUST00000110187
resolver
enst
ENSMUST00000131878
resolver
enst
ENSMUST00000146292
resolver
genesymbol
Tmem63c
resolver
genesymbol_syn
CSC1
resolver
uniprot_entry
TM63C_MOUSE
resolver
amino_acid_sequence
MSAFPDSMDQKFHNMTVNECFQSRSTVLQGQPFGGIPTVLVLNIILWVFVVLLYSFLRKAAWDYGRLALLIHNDSLTSLIYGEQSEKSSPSEVSLEAERRDRGFSSWFFNSLTMRDRDLINKCGDDARIYITFQYHLIIFVLILCIPSLGIILPVNYIGTVLDWNSHFGRTTIVNVSTESKFLWLHSLFAFLYFLINLAFMGHHCLGFVPKKSLHFTRTLMITYVPTEIQDPEIISKHFHEAYPGCVVTRVHFCYDVRNLIDLDDQRRHAMRGRLYYTAKAKKTGKVMIKTHPCSRLCFCKCWTCFKEVDAEQYYSELEEQLTDEFNAELNRVQLKRLDLIFVTFQDARTVRRIYDDYKYIHCGRHPKQSSVTTIVKNYHWRVAHAPHPKDIIWKHLSIRRFSWWTRFIAINTFLFFLFFFLTTPAIIINTIDIYNVTRPIEKLQSPIVTQFFPSVLLWAFTVTMPLLVYLSAFLEAHWTRSSQNLIIVHKCYIFLVFMVVILPSMGLTSLHVFLRWLFDIYYLEHATIRFQCVFLPDNGAFFINYVITAALLGTGMELMRLGSLCTYCTRLFLSKSEPERVHIRKNQATDFQFGREYAWMLNVFSVVMAYSITCPIIVPFGLLYLCMKHITDRYNMYYSYAPTKLNAQIHMAAVYQAIFAPLLGLFWMLFFSILRVGSLHSITLFSMSSLIISVVIAFSGVFLGKLRIAQRYEQPEEETETVFDVEPSSTTSTPTSLLYVATVLQEPELNLTPASSPARHTYGTINSQPEEGEEESGLRGFARELDSAQFQEGLEMEGQSH
uniprot
proteins
function
FUNCTION: Acts as an osmosensitive cation channel preferentially activated upon hypotonic stress (PubMed:27045885, PubMed:32375046, PubMed:37945568). In contrast to TMEM63B, does not show phospholipid scramblase activity (By similarity). Enriched in mitochondria-ER contact sites where it may regulate the metabolite flux and organelles' morphologies in response to osmotic changes (By similarity). In particular may regulate mitochondrial motility and function in motor neuron axons (By similarity). Required for the functional integrity of the kidney glomerular filtration barrier (By similarity). {ECO:0000250|UniProtKB:D3ZNF5, ECO:0000250|UniProtKB:Q9P1W3, ECO:0000269|PubMed:27045885, ECO:0000269|PubMed:32375046, ECO:0000269|PubMed:37945568}.
uniprot
proteins
mass_dalton
93011
uniprot
proteins
mutagenesis
MUTAGEN 39; /note="V->C,K: Increases calcium influx induced by hypo-osmotic stress."; /evidence="ECO:0000269|PubMed:37945568"; MUTAGEN 451; /note="Q->K: Increases calcium influx induced by hypo-osmotic stress."; /evidence="ECO:0000269|PubMed:37945568"; MUTAGEN 455; /note="S->K: Does not significantly affect calcium influx induced by hypo-osmotic stress."; /evidence="ECO:0000269|PubMed:37945568"; MUTAGEN 542; /note="F->A: Increases calcium influx induced by hypo-osmotic stress."; /evidence="ECO:0000269|PubMed:37945568"; MUTAGEN 543; /note="F->A: Increases calcium influx induced by hypo-osmotic stress."; /evidence="ECO:0000269|PubMed:37945568"; MUTAGEN 545; /note="N->C,K: Increases calcium influx induced by hypo-osmotic stress."; /evidence="ECO:0000269|PubMed:37945568"; MUTAGEN 546; /note="Y->A: Increases calcium influx induced by hypo-osmotic stress."; /evidence="ECO:0000269|PubMed:37945568
uniprot
proteins
protein_family
CSC1 (TC 1.A.17) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27045885
uniprot
proteins
pubmed
32375046
uniprot
proteins
pubmed
37945568
uniprot
proteins
sequence_length
802
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9P1W3}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:27045885, ECO:0000269|PubMed:37945568}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes at mitochondria-ER contact sites. {ECO:0000250|UniProtKB:Q9P1W3}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..60; /note="Helical; Name=TM0"; /evidence="ECO:0000305|PubMed:37945568, ECO:0007744|PDB:8K0B"; TRANSMEM 125..157; /note="Helical; Name=TM1"; /evidence="ECO:0000305|PubMed:37945568, ECO:0007744|PDB:8K0B"; TRANSMEM 181..205; /note="Helical; Name=TM2"; /evidence="ECO:0000305|PubMed:37945568, ECO:0007744|PDB:8K0B"; TRANSMEM 402..431; /note="Helical; Name=TM3"; /evidence="ECO:0000305|PubMed:37945568, ECO:0007744|PDB:8K0B"; TRANSMEM 447..476; /note="Helical; Name=TM4"; /evidence="ECO:0000305|PubMed:37945568, ECO:0007744|PDB:8K0B"; TRANSMEM 481..517; /note="Helical; Name=TM5"; /evidence="ECO:0000305|PubMed:37945568, ECO:0007744|PDB:8K0B"; TRANSMEM 541..573; /note="Helical; Name=TM6"; /evidence="ECO:0000305|PubMed:37945568, ECO:0007744|PDB:8K0B"; TRANSMEM 594..612; /note="Helical; Name=TM7"; /evidence="ECO:0000305|PubMed:37945568, ECO:0007744|PDB:8K0B"; TRANSMEM 616..640; /note="Helical; Name=TM8"; /evidence="ECO:0000305|PubMed:37945568, ECO:0007744|PDB:8K0B"; TRANSMEM 648..676; /note="Helical; Name=TM9"; /evidence="ECO:0000305|PubMed:37945568, ECO:0007744|PDB:8K0B"; TRANSMEM 682..702; /note="Helical; Name=TM10"; /evidence="ECO:0000305|PubMed:37945568, ECO:0007744|PDB:8K0B
uniprot
proteins