Irgm2
entrez
54396
canonical
uniprot
A0A140LIF8
canonical
ensembl
ENSMUSG00000069874
resolver
ensp
ENSMUSP00000056001
resolver
ensp
ENSMUSP00000104464
resolver
ensp
ENSMUSP00000146805
resolver
enst
ENSMUST00000058704
resolver
enst
ENSMUST00000108836
resolver
enst
ENSMUST00000209079
resolver
genesymbol
Irgm2
resolver
genesymbol_syn
Iigp2
resolver
uniprot
A0A9L6JKG1
resolver
uniprot
E9PVI2
resolver
uniprot
Q3TAN6
resolver
uniprot
Q3TNE5
resolver
uniprot
Q3U635
resolver
uniprot
Q9Z1M2
resolver
uniprot_entry
A0A9L6JKG1_MOUSE
resolver
uniprot_entry
IRGM2_MOUSE
resolver
uniprot_sec
E9PVI2
resolver
uniprot_sec
Q3TAN6
resolver
uniprot_sec
Q3TNE5
resolver
uniprot_sec
Q3U635
resolver
uniprot_sec
Q9Z1M2
resolver
amino_acid_sequence
MEEAVESPEVKEFEYFSDAVFIPKDGNTLSVGVIKRIETAVKEGEVVKVVSIVKEIIQNVSRNKIKIAVTGDSGNGMSSFINALRLIGHEEKDSAPTGVVRTTQKPTCYFSSHFPYVELWDLPGLGATAQSVESYLEEMQISIYDLIIIVASEQFSLNHVKLAITMQRMRKRFYVVWTKLDRDLSTSTFPEPQLLQSIQRNIRDSLQKEKVKEHPMFLVSVFKPESHDFPKLRETLQKDLPVIKYHGLVETLYQVCEKTVNERVESIKKSIDEDNLHTEFGISDPGNAIEIRKAFQKTFGLDDISLHLVALEMKNKHFNTSMESQETQRYQQDDWVLARLYRTGTRVGSIGFDYMKCCFTSHHSRCKQQKDILDETAAKAKEVLLKILRLSIPHP
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Immunity-related GTPase that plays important roles in innate immunity and inflammatory response (PubMed:17641048, PubMed:33124745, PubMed:33124769, PubMed:34078740, PubMed:34338548). Acts as a dynamin-like protein that binds to intracellular membranes and promotes remodeling and trafficking of those membranes (By similarity). Required for clearance of acute protozoan and bacterial infections (PubMed:17641048, PubMed:34078740, PubMed:34338548). Acts by participating to Tgtp1/Irgb6 and Gbp1-mediated parasite killing by promoting their accumulation on the T.gondii parasitophorous vacuole membranes (PubMed:34078740). Also required for prolonged loading of ubiquitin and p62/Sqstm1 to parasitophorous vacuole membranes (PubMed:34078740). Also acts as a key negative regulator of the inflammatory response by inhibiting the non-canonical inflammasome, thereby protecting against Casp11-driven septic shock during endotoxemia (PubMed:33124745, PubMed:33124769). {ECO:0000250|UniProtKB:Q60766, ECO:0000269|PubMed:17641048, ECO:0000269|PubMed:33124745, ECO:0000269|PubMed:33124769, ECO:0000269|PubMed:34078740, ECO:0000269|PubMed:34338548}.
uniprot
proteins
mass_dalton
45205
uniprot
proteins
mutagenesis
MUTAGEN 77; /note="M->A: Abolished GTPase activity, preventing ability to mediate host resistance to acute infection by T.gondii."; /evidence="ECO:0000269|PubMed:34078740"; MUTAGEN 92; /note="K->A: Abolished polyubiquitination; when associated with A-269, A-314, A-316 and A-379."; /evidence="ECO:0000269|PubMed:34078740"; MUTAGEN 269; /note="K->A: Abolished polyubiquitination; when associated with A-92, A-314, A-316 and A-379."; /evidence="ECO:0000269|PubMed:34078740"; MUTAGEN 314; /note="K->A: Abolished polyubiquitination; when associated with A-92, A-269, A-316 and A-379."; /evidence="ECO:0000269|PubMed:34078740"; MUTAGEN 316; /note="K->A: Abolished polyubiquitination; when associated with A-92, A-269, A-314 and A-379."; /evidence="ECO:0000269|PubMed:34078740"; MUTAGEN 357; /note="C->A: Does not affect localization to parasitophorous vacuole membranes or Golgi apparatus."; /evidence="ECO:0000269|PubMed:34078740"; MUTAGEN 358; /note="C->A: Abolished localization to parasitophorous vacuole membranes or Golgi apparatus."; /evidence="ECO:0000269|PubMed:34078740"; MUTAGEN 379; /note="K->A: Abolished polyubiquitination; when associated with A-92, A-269, A-314 and A-316."; /evidence="ECO:0000269|PubMed:34078740
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; polyubiquitinated in the cytosol, promoting Gbp1 recruitment to the T.gondii parasitophorous vacuole membranes. {ECO:0000269|PubMed:34078740}.
uniprot
proteins
protein_family
IRG family
uniprot
proteins
protein_family
TRAFAC class dynamin-like GTPase superfamily
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17641048
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22892676
uniprot
proteins
pubmed
33124745
uniprot
proteins
pubmed
33124769
uniprot
proteins
pubmed
34078740
uniprot
proteins
pubmed
34338548
uniprot
proteins
pubmed
36629440
uniprot
proteins
pubmed
9862701
uniprot
proteins
sequence_length
395
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:34078740}. Golgi apparatus membrane {ECO:0000269|PubMed:34078740}. Cytoplasm, cytosol {ECO:0000269|PubMed:34078740}. Note=Localizes to parasitophorous vacuole membranes. {ECO:0000269|PubMed:34078740}.
uniprot
proteins