TAF4B
entrez
6875
canonical
uniprot
Q92750
canonical
ensembl
ENSG00000141384
resolver
ensp
ENSP00000269142
resolver
ensp
ENSP00000462980
resolver
ensp
ENSP00000730910
resolver
ensp
ENSP00000791862
resolver
enst
ENST00000578121
resolver
genesymbol
TAF4B
resolver
genesymbol_syn
TAF2C2
resolver
genesymbol_syn
TAFII105
resolver
hgnc
HGNC:11538
resolver
uniprot
B4DYT3
resolver
uniprot
J3KTH2
resolver
uniprot
Q29YA4
resolver
uniprot
Q29YA5
resolver
uniprot_entry
B4DYT3_HUMAN
resolver
uniprot_entry
J3KTH2_HUMAN
resolver
uniprot_entry
TAF4B_HUMAN
resolver
uniprot_sec
Q29YA4
resolver
uniprot_sec
Q29YA5
resolver
amino_acid_sequence
MPAGLTEPAGAAPPAAVSASGTVTMAPAGALPVRVESTPVALGAVTKAPVSVCVEPTASQPLRSPVGTLVTKVAPVSAPPKVSSGPRLPAPQIVAVKAPNTTTIQFPANLQLPPGTVLIKSNSGPLMLVSPQQTVTRAETTSNITSRPAVPANPQTVKICTVPNSSSQLIKKVAVTPVKKLAQIGTTVVTTVPKPSSVQSVAVPTSVVTVTPGKPLNTVTTLKPSSLGASSTPSNEPNLKAENSAAVQINLSPTMLENVKKCKNFLAMLIKLACSGSQSPEMGQNVKKLVEQLLDAKIEAEEFTRKLYVELKSSPQPHLVPFLKKSVVALRQLLPNSQSFIQQCVQQTSSDMVIATCTTTVTTSPVVTTTVSSSQSEKSIIVSGATAPRTVSVQTLNPLAGPVGAKAGVVTLHSVGPTAATGGTTAGTGLLQTSKPLVTSVANTVTTVSLQPEKPVVSGTAVTLSLPAVTFGETSGAAICLPSVKPVVSSAGTTSDKPVIGTPVQIKLAQPGPVLSQPAGIPQAVQVKQLVVQQPSGGNEKQVTTISHSSTLTIQKCGQKTMPVNTIIPTSQFPPASILKQITLPGNKILSLQASPTQKNRIKENVTSCFRDEDDINDVTSMAGVNLNEENACILATNSELVGTLIQSCKDEPFLFIGALQKRILDIGKKHDITELNSDAVNLISQATQERLRGLLEKLTAIAQHRMTTYKASENYILCSDTRSQLKFLEKLDQLEKQRKDLEEREMLLKAAKSRSNKEDPEQLRLKQKAKELQQLELAQIQHRDANLTALAAIGPRKKRPLESGIEGLKDNLLASGTSSLTATKQLHRPRITRICLRDLIFCMEQEREMKYSRALYLALLK
uniprot
proteins
disease_involvement
DISEASE: Spermatogenic failure 13 (SPGF13) [MIM:615841]: A disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. {ECO:0000269|PubMed:24431330}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis. {ECO:0000250|UniProtKB:G5E8Z2, ECO:0000269|PubMed:10828057, ECO:0000269|PubMed:10849440, ECO:0000269|PubMed:16088961, ECO:0000303|PubMed:24431330}.
uniprot
proteins
mass_dalton
91091
uniprot
proteins
post_translational_modification
PTM: Under stimulation by forskolin, Isoform 1 is phosphorylated by protein kinase A (PKA). {ECO:0000269|PubMed:16088961}.
uniprot
proteins
protein_family
TAF4 family
uniprot
proteins
pubmed
10828057
uniprot
proteins
pubmed
10849440
uniprot
proteins
pubmed
11567023
uniprot
proteins
pubmed
15601843
uniprot
proteins
pubmed
16088961
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24431330
uniprot
proteins
pubmed
8858156
uniprot
proteins
sequence_length
862
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11567023, ECO:0000269|PubMed:16088961}. Cytoplasm {ECO:0000269|PubMed:11567023, ECO:0000269|PubMed:16088961}. Note=Export into the cytoplasm is mediated by a CRM1-independent nuclear export pathway and not by phosphorylation. {ECO:0000269|PubMed:11567023}.
uniprot
proteins