BEX1
entrez
55859
canonical
uniprot
Q9HBH7
canonical
ensembl
ENSG00000133169
resolver
ensp
ENSP00000361813
resolver
ensp
ENSP00000555639
resolver
ensp
ENSP00000555640
resolver
ensp
ENSP00000555641
resolver
ensp
ENSP00000555642
resolver
ensp
ENSP00000555643
resolver
ensp
ENSP00000604008
resolver
ensp
ENSP00000604009
resolver
ensp
ENSP00000604010
resolver
ensp
ENSP00000604011
resolver
ensp
ENSP00000604012
resolver
ensp
ENSP00000604013
resolver
ensp
ENSP00000604014
resolver
ensp
ENSP00000623485
resolver
enst
ENST00000372728
resolver
enst
ENST00000885580
resolver
enst
ENST00000885581
resolver
enst
ENST00000885582
resolver
enst
ENST00000885583
resolver
enst
ENST00000885584
resolver
enst
ENST00000933949
resolver
enst
ENST00000933950
resolver
enst
ENST00000933951
resolver
enst
ENST00000933952
resolver
enst
ENST00000933953
resolver
enst
ENST00000933954
resolver
enst
ENST00000933955
resolver
enst
ENST00000953426
resolver
genesymbol
BEX1
resolver
hgnc
HGNC:1036
resolver
uniprot
A0AVN1
resolver
uniprot
A8K4J3
resolver
uniprot
Q9NZ33
resolver
uniprot_entry
BEX1_HUMAN
resolver
uniprot_sec
A0AVN1
resolver
uniprot_sec
A8K4J3
resolver
uniprot_sec
Q9NZ33
resolver
amino_acid_sequence
MESKEKRAVNSLSMENANQENEEKEQVANKGEPLALPLDAGEYCVPRGNRRRFRVRQPILQYRWDMMHRLGEPQARMREENMERIGEEVRQLMEKLREKQLSHSLRAVSTDPPHHDHHDEFCLMP
uniprot
proteins
function
FUNCTION: Signaling adapter molecule involved in p75NTR/NGFR signaling. Plays a role in cell cycle progression and neuronal differentiation. Inhibits neuronal differentiation in response to nerve growth factor (NGF). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity). {ECO:0000250|UniProtKB:Q3MKQ2, ECO:0000250|UniProtKB:Q9R224}.
uniprot
proteins
mass_dalton
14860
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation of Ser-102 protects it from the proteasome. {ECO:0000250|UniProtKB:Q3MKQ2}.; PTM: Ubiquitinated. Degraded by the proteasome. {ECO:0000250|UniProtKB:Q3MKQ2}.
uniprot
proteins
protein_family
BEX family
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
11989783
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
15920485
uniprot
proteins
pubmed
15958283
uniprot
proteins
sequence_length
125
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q3MKQ2}. Cytoplasm {ECO:0000250|UniProtKB:Q3MKQ2}. Note=Shuttles between the cytoplasm and the nucleus. Predominantly nuclear. {ECO:0000250|UniProtKB:Q3MKQ2}.
uniprot
proteins