IRAK3
entrez
11213
canonical
uniprot
Q9Y616
canonical
ensembl
ENSG00000090376
resolver
ensp
ENSP00000261233
resolver
ensp
ENSP00000409852
resolver
genesymbol
IRAK3
resolver
hgnc
HGNC:17020
resolver
uniprot
B4DQ57
resolver
uniprot_entry
IRAK3_HUMAN
resolver
uniprot_sec
B4DQ57
resolver
amino_acid_sequence
MAGNCGARGALSAHTLLFDLPPALLGELCAVLDSCDGALGWRGLAERLSSSWLDVRHIEKYVDQGKSGTRELLWSWAQKNKTIGDLLQVLQEMGHRRAIHLITNYGAVLSPSEKSYQEGGFPNILFKETANVTVDNVLIPEHNEKGILLKSSISFQNIIEGTRNFHKDFLIGEGEIFEVYRVEIQNLTYAVKLFKQEKKMQCKKHWKRFLSELEVLLLFHHPNILELAAYFTETEKFCLIYPYMRNGTLFDRLQCVGDTAPLPWHIRIGILIGISKAIHYLHNVQPCSVICGSISSANILLDDQFQPKLTDFAMAHFRSHLEHQSCTINMTSSSSKHLWYMPEEYIRQGKLSIKTDVYSFGIVIMEVLTGCRVVLDDPKHIQLRDLLRELMEKRGLDSCLSFLDKKVPPCPRNFSAKLFCLAGRCAATRAKLRPSMDEVLNTLESTQASLYFAEDPPTSLKSFRCPSPLFLENVPSIPVEDDESQNNNLLPSDEGLRIDRMTQKTPFECSQSEVMFLSLDKKPESKRNEEACNMPSSSCEESWFPKYIVPSQDLRPYKVNIDPSSEAPGHSCRSRPVESSCSSKFSWDEYEQYKKE
uniprot
proteins
disease_involvement
DISEASE: Asthma-related traits 5 (ASRT5) [MIM:611064]: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. {ECO:0000269|PubMed:17503328}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Putative inactive protein kinase which regulates signaling downstream of immune receptors including IL1R and Toll-like receptors (PubMed:10383454, PubMed:29686383). Inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex (By similarity). Upon IL33-induced lung inflammation, positively regulates expression of IL6, CSF3, CXCL2 and CCL5 mRNAs in dendritic cells (PubMed:29686383). {ECO:0000250|UniProtKB:Q8K4B2, ECO:0000269|PubMed:10383454, ECO:0000269|PubMed:29686383}.
uniprot
proteins
mass_dalton
67767
uniprot
proteins
mutagenesis
MUTAGEN 110; /note="S->A: Abolishes phosphorylation. Abolishes interaction with PIN1. Reduces protein stability."; /evidence="ECO:0000269|PubMed:29686383"; MUTAGEN 110; /note="S->E: Phosphomimic. Slight decrease in the interaction with PIN1. Weak interaction with PIN1 in absence of IL33-mediated dendritic cell stimulation. Increases resistant to degradation. Localizes to the nucleus in absence of stimulus. Does not affect isomerization of Pro-111 peptide bond."; /evidence="ECO:0000269|PubMed:29686383"; MUTAGEN 210; /note="L->E: Abolishes dimerization."; /evidence="ECO:0000269|PubMed:33238146"; MUTAGEN 214; /note="E->L: Enhances dimerization."; /evidence="ECO:0000269|PubMed:33238146"; MUTAGEN 467; /note="S->A: No effect on the interaction with PIN1."; /evidence="ECO:0000269|PubMed:29686383
uniprot
proteins
protein_family
Pelle subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
TKL Ser/Thr protein kinase family
uniprot
proteins
pubmed
10383454
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17503328
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
29686383
uniprot
proteins
pubmed
33238146
uniprot
proteins
sequence_length
596
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:29686383}. Nucleus {ECO:0000269|PubMed:29686383}. Note=In dendritic cells, translocates into the nucleus upon IL33 stimulation. {ECO:0000250|UniProtKB:Q8K4B2}.
uniprot
proteins