Nrip1
entrez
268903
canonical
uniprot
Q8CBD1
canonical
ensembl
ENSMUSG00000048490
resolver
ensp
ENSMUSP00000051726
resolver
ensp
ENSMUSP00000112959
resolver
ensp
ENSMUSP00000206738
resolver
ensp
ENSMUSP00000206740
resolver
ensp
ENSMUSP00000206744
resolver
enst
ENSMUST00000054178
resolver
enst
ENSMUST00000121927
resolver
genesymbol
Nrip1
resolver
uniprot
Q3U166
resolver
uniprot
Q8C3Y8
resolver
uniprot
Q9Z2K2
resolver
uniprot_entry
NRIP1_MOUSE
resolver
uniprot_sec
Q3U166
resolver
uniprot_sec
Q8C3Y8
resolver
uniprot_sec
Q9Z2K2
resolver
amino_acid_sequence
MTHGEELGSDVHQDSIVLTYLEGLLMHQAAGGSGTAINKKSAGHKEEDQNFNLSGSAFPSCQSNGPTVSTQTYQGSGMLHLKKARLLQSSEDWNAAKRKRLSDSIVNLNVKKEALLAGMVDSVPKGKQDSTLLASLLQSFSSRLQTVALSQQIRQSLKEQGYALSHESLKVEKDLRCYGVASSHLKTLLKKSKTKDQKSGPTLPDVTPNLIRDSFVESSHPAVGQSGTKVMSEPLSCAARLQAVASMVEKRASPAASPKPSVACSQLALLLSSEAHLQQYSREHALKTQNAHQVASERLAAMARLQENGQKDVGSSQLSKGVSGHLNGQARALPASKLVANKNNAATFQSPMGVVPSSPKNTSYKNSLERNNLKQAANNSLLLHLLKSQTIPTPMNGHSQNERASSFESSTPTTIDEYSDNNPSFTDDSSGDESSYSNCVPIDLSCKHRIEKPEAERPVSLENLTQSLLNTWDPKIPGVDIKEDQDTSTNSKLNSHQKVTLLQLLLGHKSEETVERNASPQDIHSDGTKFSPQNYTRTSVIESPSTNRTTPVSTPPLYTASQAESPINLSQHSLVIKWNSPPYACSTPASKLTNTAPSHLMDLTKGKESQAEKPAPSEGAQNSATFSASKLLQNLAQCGLQSSGPGEEQRPCKQLLSGNPDKPLGLIDRLNSPLLSNKTNAAEESKAFSSQPAGPEPGLPGCEIENLLERRTVLQLLLGNSSKGKNEKKEKTPARDEAPQEHSERAANEQILMVKIKSEPCDDFQTHNTNLPLNHDAKSAPFLGVTPAIHRSTAALPVSEDFKSEPASPQDFSFSKNGLLSRLLRQNQESYPADEQDKSHRNSELPTLESKNICMVPKKRKLYTEPLENPFKKMKNTAVDTANHHSGPEVLYGSLLHQEELKFSRNELDYKYPAGHSSASDGDHRSWARESKSFNVLKQLLLSENCVRDLSPHRSDSVPDTKKKGHKNNAPGSKPEFGISSLNGLMYSSPQPGSCVTDHRTFSYPGMVKTPLSPPFPEHLGCVGSRPEPGLLNGCSVPGEKGPIKWVIADMDKNEYEKDSPRLTKTNPILYYMLQKGGGNSVTTQETQDKDIWREPASAESLSQVTVKEELLPAAETKASFFNLRSPYNSHMGNNASRPHSTNGEVYGLLGNALTIKKESE
uniprot
proteins
function
FUNCTION: Modulates transcriptional repression by nuclear hormone receptors such as NR2C1, thyroid hormone receptor and retinoic acid receptor/RARA. Essential for cumulus expansion and follicle rupture during ovulation. Also controls the balance between fat accumulation and energy expenditure. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function (PubMed:11100122). Plays a role in renal development (PubMed:28381549). {ECO:0000269|PubMed:10531331, ECO:0000269|PubMed:11100122, ECO:0000269|PubMed:15130509, ECO:0000269|PubMed:15155905, ECO:0000269|PubMed:15919748, ECO:0000269|PubMed:21628546, ECO:0000269|PubMed:28381549, ECO:0000269|PubMed:9774688}.
uniprot
proteins
mass_dalton
126337
uniprot
proteins
mutagenesis
MUTAGEN 1067; /note="N->G: Reduces binding to RAR, RXR and RAR/RXR."; /evidence="ECO:0000269|PubMed:12549917"; MUTAGEN 1068; /note="P->A: Abolishes binding to RAR, RXR and RAR/RXR."; /evidence="ECO:0000269|PubMed:12549917"; MUTAGEN 1073; /note="M->I: Reduces binding to RAR, RXR and RAR/RXR."; /evidence="ECO:0000269|PubMed:12549917"; MUTAGEN 1073; /note="M->K: Abolishes binding to RAR, RXR and RAR/RXR."; /evidence="ECO:0000269|PubMed:12549917"; MUTAGEN 1073; /note="M->L: Reduces binding to RAR, RXR and RAR/RXR."; /evidence="ECO:0000269|PubMed:12549917
uniprot
proteins
post_translational_modification
PTM: Acetylation abolishes interaction with CTBP1. Phosphorylation enhances interaction with YWHAH (By similarity). Acetylation regulates its nuclear translocation and corepressive activity. {ECO:0000250|UniProtKB:P48552, ECO:0000269|PubMed:15846843, ECO:0000269|PubMed:15879431}.
uniprot
proteins
pubmed
10531331
uniprot
proteins
pubmed
11006275
uniprot
proteins
pubmed
11100122
uniprot
proteins
pubmed
11278635
uniprot
proteins
pubmed
12549917
uniprot
proteins
pubmed
15130509
uniprot
proteins
pubmed
15155905
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15846843
uniprot
proteins
pubmed
15879431
uniprot
proteins
pubmed
15919748
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17187077
uniprot
proteins
pubmed
18682553
uniprot
proteins
pubmed
21628546
uniprot
proteins
pubmed
28381549
uniprot
proteins
pubmed
9774688
uniprot
proteins
sequence_length
1161
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15879431}.
uniprot
proteins