PKMYT1
entrez
9088
canonical
uniprot
Q99640
canonical
ensembl
ENSG00000127564
resolver
ensp
ENSP00000262300
resolver
ensp
ENSP00000397739
resolver
ensp
ENSP00000458943
resolver
ensp
ENSP00000459123
resolver
ensp
ENSP00000460868
resolver
ensp
ENSP00000566721
resolver
ensp
ENSP00000604513
resolver
genesymbol
PKMYT1
resolver
genesymbol_syn
MYT1
resolver
hgnc
HGNC:29650
resolver
uniprot
B3KUN8
resolver
uniprot
B4DXD4
resolver
uniprot
D3DUA4
resolver
uniprot
F8W164
resolver
uniprot
I3L1V2
resolver
uniprot
O14731
resolver
uniprot
Q0IJ49
resolver
uniprot
Q7LE24
resolver
uniprot
Q8TCM9
resolver
uniprot_entry
PMYT1_HUMAN
resolver
uniprot_entry
Q0IJ49_HUMAN
resolver
uniprot_sec
B3KUN8
resolver
uniprot_sec
B4DXD4
resolver
uniprot_sec
D3DUA4
resolver
uniprot_sec
F8W164
resolver
uniprot_sec
I3L1V2
resolver
uniprot_sec
O14731
resolver
uniprot_sec
Q7LE24
resolver
uniprot_sec
Q8TCM9
resolver
activity_regulation
ACTIVITY REGULATION: Negatively regulated by hyperphosphorylation during mitosis (PubMed:9268380). The hyperphosphorylated form does not associate with CCNB1-CDC2 complexes (PubMed:9268380). The PLK1 protein kinase may be required for mitotic phosphorylation (PubMed:9268380). {ECO:0000269|PubMed:9268380}.
uniprot
proteins
amino_acid_sequence
MLERPPALAMPMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPRGLSRSLPPPPPAKGSIPISRLFPPRTPGWHQLQPRRVSFRGEASETLQSPGYDPSRPESFFQQSFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRSMSPFRGPKDRARKLAEVGSHEKVGQHPCCVRLEQAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDTLLALAHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGTAGAGEVQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLVMMLEPDPKLRATAEALLALPVLRQPRAWGVLWCMAAEALSRGWALWQALLALLCWLWHGLAHPASWLQPLGPPATPPGSPPCSLLLDSSLSSNWDDDSLGPSLSPEAVLARTVGSTSTPRSRCTPRDALDLSDINSEPPRGSFPSFEPRNLLSLFEDTLDPT
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins (PubMed:10373560, PubMed:10504341, PubMed:9001210, PubMed:9268380). Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation (PubMed:9001210, PubMed:9268380). May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect (PubMed:9001210, PubMed:9268380). {ECO:0000269|PubMed:10373560, ECO:0000269|PubMed:10504341, ECO:0000269|PubMed:9001210, ECO:0000269|PubMed:9268380}.
uniprot
proteins
mass_dalton
54521
uniprot
proteins
mutagenesis
MUTAGEN 238; /note="N->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:10373560"; MUTAGEN 251; /note="D->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:10504341"; MUTAGEN 486..488; /note="RNL->AAA: Loss of CDC2-CCNB1 interaction."; /evidence="ECO:0000269|PubMed:10373560
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. Phosphorylated by CDC2-CCNB1 complexes on undefined serine and threonine residues. The phosphorylation by CDC2-CCNB1 complexes may inhibit the catalytic activity. {ECO:0000269|PubMed:10504341, ECO:0000269|PubMed:12738781}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Ser/Thr protein kinase family
uniprot
proteins
protein_family
WEE1 subfamily
uniprot
proteins
pubmed
10373560
uniprot
proteins
pubmed
10504341
uniprot
proteins
pubmed
12738781
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
9001210
uniprot
proteins
pubmed
9268380
uniprot
proteins
pubmed
9499405
uniprot
proteins
sequence_length
499
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:9001210}; Peripheral membrane protein {ECO:0000269|PubMed:9001210}. Golgi apparatus membrane {ECO:0000269|PubMed:9001210}; Peripheral membrane protein {ECO:0000269|PubMed:9001210}.
uniprot
proteins