Acot8
entrez
170789
canonical
uniprot
P58137
canonical
ensembl
ENSMUSG00000017307
resolver
ensp
ENSMUSP00000017451
resolver
ensp
ENSMUSP00000099383
resolver
enst
ENSMUST00000017451
resolver
enst
ENSMUST00000103094
resolver
genesymbol
Acot8
resolver
genesymbol_syn
Pte1
resolver
uniprot
F8WI54
resolver
uniprot
Q3U965
resolver
uniprot
Q8BZR4
resolver
uniprot
Q8VHM4
resolver
uniprot_entry
ACOT8_MOUSE
resolver
uniprot_entry
F8WI54_MOUSE
resolver
uniprot_entry
Q3U965_MOUSE
resolver
uniprot_entry
Q8BZR4_MOUSE
resolver
uniprot_sec
Q8VHM4
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by CoASH (IC(50)=10-15 uM). Also inhibited by cysteine-reactive agents. {ECO:0000269|PubMed:11673457}.
uniprot
proteins
amino_acid_sequence
MSAPEGLGDAHGDADRGDLSGDLRSVLVTSVLNLEPLDEDLYRGRHYWVPTSQRLFGGQIMGQALVAAAKSVSEDVHVHSLHCYFVRAGDPKVPVLYHVERIRTGASFSVRAVKAVQHGKAIFICQASFQQMQPSPLQHQFSMPSVPPPEDLLDHEALIDQYLRDPNLHKKYRVGLNRVAAQEVPIEIKVVNPPTLTQLQALEPKQMFWVRARGYIGEGDIKMHCCVAAYISDYAFLGTALLPHQSKYKVNFMASLDHSMWFHAPFRADHWMLYECESPWAGGSRGLVHGRLWRRDGVLAVTCAQEGVIRLKPQVSESKL
uniprot
proteins
ec_number
3.1.2.1
uniprot
proteins
ec_number
3.1.2.11
uniprot
proteins
ec_number
3.1.2.2
uniprot
proteins
ec_number
3.1.2.27
uniprot
proteins
ec_number
3.1.2.3
uniprot
proteins
ec_number
3.1.2.5
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:11673457). Displays no strong substrate specificity with respect to the carboxylic acid moiety of Acyl-CoAs (PubMed:11673457). Hydrolyzes medium length (C2 to C20) straight-chain, saturated and unsaturated acyl-CoAS but is inactive towards substrates with longer aliphatic chains (PubMed:11673457). Moreover, it catalyzes the hydrolysis of CoA esters of bile acids, such as choloyl-CoA and chenodeoxycholoyl-CoA and competes with bile acid CoA:amino acid N-acyltransferase (BAAT) (PubMed:11673457). Is also able to hydrolyze CoA esters of dicarboxylic acids (PubMed:16141203). It is involved in the metabolic regulation of peroxisome proliferation (By similarity). {ECO:0000250|UniProtKB:O14734, ECO:0000269|PubMed:11673457, ECO:0000269|PubMed:16141203}.
uniprot
proteins
mass_dalton
35827
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid metabolism. {ECO:0000305|PubMed:11673457}.
uniprot
proteins
protein_family
C/M/P thioester hydrolase family
uniprot
proteins
pubmed
11673457
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141203
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
320
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome matrix {ECO:0000269|PubMed:11673457}. Note=Predominantly localized in the peroxisome but a localization to the cytosol cannot be excluded. {ECO:0000250|UniProtKB:O14734}.
uniprot
proteins