SPSB2
entrez
84727
canonical
uniprot
Q99619
canonical
ensembl
ENSG00000111671
resolver
ensp
ENSP00000428338
resolver
ensp
ENSP00000430872
resolver
ensp
ENSP00000560154
resolver
genesymbol
SPSB2
resolver
genesymbol_syn
GRCC9
resolver
genesymbol_syn
SSB2
resolver
hgnc
HGNC:29522
resolver
uniprot
B7Z4W1
resolver
uniprot
D3DUT0
resolver
uniprot_entry
SPSB2_HUMAN
resolver
uniprot_sec
B7Z4W1
resolver
uniprot_sec
D3DUT0
resolver
amino_acid_sequence
MGQTALAGGSSSTPTPQALYPDLSCPEGLEELLSAPPPDLGAQRRHGWNPKDCSENIEVKEGGLYFERRPVAQSTDGARGKRGYSRGLHAWEISWPLEQRGTHAVVGVATALAPLQTDHYAALLGSNSESWGWDIGRGKLYHQSKGPGAPQYPAGTQGEQLEVPERLLVVLDMEEGTLGYAIGGTYLGPAFRGLKGRTLYPAVSAVWGQCQVRIRYLGERRAEPHSLLHLSRLCVRHNLGDTRLGQVSALPLPPAMKRYLLYQ
uniprot
proteins
function
FUNCTION: Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199876). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876). {ECO:0000269|PubMed:15601820, ECO:0000269|PubMed:21199876}.
uniprot
proteins
mass_dalton
28630
uniprot
proteins
mutagenesis
MUTAGEN 116..119; /note="QTDH->HSVG: Enhances interaction with PAWR."; /evidence="ECO:0000269|PubMed:16498413
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
SPSB family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15601820
uniprot
proteins
pubmed
15713673
uniprot
proteins
pubmed
16498413
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
20561531
uniprot
proteins
pubmed
21199876
uniprot
proteins
pubmed
31344133
uniprot
proteins
pubmed
9074930
uniprot
proteins
sequence_length
263
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Cytoplasm, cytosol {ECO:0000269|PubMed:21199876}. Note=Exhibits a diffuse cytosolic localization. {ECO:0000269|PubMed:21199876}.
uniprot
proteins