Coq8a
entrez
360887
canonical
uniprot
Q5BJQ0
canonical
ensembl
ENSRNOG00000043201
resolver
ensembl
ENSRNOG00055012372
resolver
ensembl
ENSRNOG00060006754
resolver
ensembl
ENSRNOG00065023604
resolver
ensp
ENSRNOP00000036948
resolver
ensp
ENSRNOP00055017040
resolver
ensp
ENSRNOP00060008277
resolver
ensp
ENSRNOP00065032888
resolver
enst
ENSRNOT00055021073
resolver
enst
ENSRNOT00060011082
resolver
enst
ENSRNOT00065040391
resolver
genesymbol
Coq8a
resolver
genesymbol_syn
Adck3
resolver
genesymbol_syn
Cabc1
resolver
uniprot_entry
COQ8A_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Autoinhibited by the N-terminal domain, containing the KxGQ motif, that completely occludes the typical substrate binding pocket. Nucleotide-binding relieves inhibition. {ECO:0000250|UniProtKB:Q8NI60}.
uniprot
proteins
amino_acid_sequence
MAAMLGDAIMVAKGLAKLTQAAVETHLQNLGLGGELILAARALQSTAVEQISMVFGKVQGQDKHEDSYATENFEDLEAEVQFSTPQAAGSSPDFSTASSLDQPLSSSLGHAHREGPAPAYVSSGPFREAGLSGQATSPLGRVNGRLFVDCRDLFLANSIQRRFFHQDQAPVGGLTAEDIEKARQAKARPESKPHKQMLSERARERKVPVTRIGRLANFGGLAVGLGFGALAEVAKKSLRSENSTGKKAVLDSSPFLSEANAERIVSTLCKVRGAALKLGQMLSIQDDAFINPHLAKIFERVRQSADFMPLKQMTKTLNNDLGPHWRDKLEYFEERPFAAASIGQVHLARLKGGREVAMKIQYPGVAQSINSDVNNLMAVLNMSNMLPEGLFPEHLIDVLRRELTLECDYQREAAYAKKFRELLKDHPFFYVPEIVDELCSPHVLTTELITGFPLDQAEGLSQEVRNEICYNILVLCLRELFEFHVMQTDPNWSNFFYDPQQHKVALLDFGATREYDRSFTDLYIQVIRAAADQDREAVLKKSIEMKFLTGYEVKAMEDAHLDAILILGEAFASEEPFDFGTQSTTEKIHNLIPIMLKHRLIPPPEETYSLHRKMGGSFLICSKLKACFPCKAMFEEAYSNYCRMKSGLQ
uniprot
proteins
ec_number
2.7.-.-
uniprot
proteins
function
FUNCTION: Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (By similarity). Its substrate specificity is still unclear: may act as a protein kinase that mediates phosphorylation of COQ3 (By similarity). According to other reports, acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates (By similarity). However, the small molecule kinase activity was not confirmed by another publication (By similarity). Shows an unusual selectivity for binding ADP over ATP (By similarity). {ECO:0000250|UniProtKB:Q8NI60, ECO:0000250|UniProtKB:Q96D53}.
uniprot
proteins
mass_dalton
72226
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis. {ECO:0000250|UniProtKB:Q8NI60}.
uniprot
proteins
protein_family
ADCK protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
649
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250|UniProtKB:Q8NI60}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 215..231; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins