Npas1
entrez
18142
canonical
uniprot
P97459
canonical
ensembl
ENSMUSG00000001988
resolver
ensp
ENSMUSP00000002053
resolver
ensp
ENSMUSP00000147412
resolver
ensp
ENSMUSP00000265924
resolver
ensp
ENSMUSP00000265925
resolver
ensp
ENSMUSP00000265927
resolver
enst
ENSMUST00000002053
resolver
enst
ENSMUST00000210748
resolver
genesymbol
Npas1
resolver
uniprot
A2RSH6
resolver
uniprot_entry
A2RSH6_MOUSE
resolver
uniprot_entry
NPAS1_MOUSE
resolver
amino_acid_sequence
MATPYPRSGGRGEVKCGGGRGAGVPWDFLPGLMVKAPPGPCLQAQRKEKSRNAARWRRGKENLEFFELAKLLPLPGAISSQLDKASIVRLSVTYLRLRRFAALGAPPWGLRAVGPPAGLAPGRRGPVALVSEVFEQHLGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYIHPGDHSEVLEQLGLRAASIGPPTPPSVSSSSSSSSSSLVDTPEIEASPTEASPAFRAQERSFFVRMKSTLTKRGLNVKASGYKVIHVTGRLRARALGLVALGHTLPPAPLAELPLHGHMIVFRLSLGLTILACESRVSDHMDMGPSELVGRSCYQFVHGQDATRIRQSHLDLLDKGQVVTGYYRWLQRAGGFVWLQSVATVAGNGKSTGEHHVLWVSHVLSNAEGSQTPLDAFQLPAIVSQEEPSRPGPEPTEEEPPVDGKQAVPADQDKDKDPQARGKRIKVEASPKEARGSEDSGEEELSDPPAPPRPEFTSVIRAGALKHDPVLPWGLTTPGDPSPALLHAGFLPPVVRGLCTPGTIRYGPAELSLMYPHLHRLGAGPSLPEAFYPTLGLPYPGPTGTRVQRKGD
uniprot
proteins
function
FUNCTION: May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by modulating EPO expression in response to cellular oxygen level. Forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) leading to transcriptional repression on its target gene TH (PubMed:27782878). {ECO:0000269|PubMed:15347806, ECO:0000269|PubMed:15635607, ECO:0000269|PubMed:27782878}.
uniprot
proteins
mass_dalton
63737
uniprot
proteins
mutagenesis
MUTAGEN 249; /note="F->D: Destabilizes heterodimerization with ARNT. Compromises the transcriptional repression activity of heterodimer ARNT:NPAS1."; /evidence="ECO:0000269|PubMed:27782878"; MUTAGEN 251; /note="R->A: Destabilizes heterodimerization with ARNT. Compromises the transcriptional repression activity of heterodimer ARNT:NPAS1."; /evidence="ECO:0000269|PubMed:27782878"; MUTAGEN 270; /note="V->D: Destabilizes heterodimerization with ARNT. Compromises the transcriptional repression activity of heterodimer ARNT:NPAS1."; /evidence="ECO:0000269|PubMed:27782878"; MUTAGEN 272; /note="H->A: Destabilizes heterodimerization with ARNT. Compromises the transcriptional repression activity of heterodimer ARNT:NPAS1."; /evidence="ECO:0000269|PubMed:27782878
uniprot
proteins
pubmed
15347806
uniprot
proteins
pubmed
15635607
uniprot
proteins
pubmed
27782878
uniprot
proteins
pubmed
9012850
uniprot
proteins
sequence_length
594
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins