NTRK3
entrez
4916
canonical
uniprot
Q16288
canonical
ensembl
ENSG00000140538
resolver
ensp
ENSP00000318328
resolver
ensp
ENSP00000377990
resolver
ensp
ENSP00000437773
resolver
ensp
ENSP00000453511
resolver
ensp
ENSP00000453959
resolver
ensp
ENSP00000485864
resolver
ensp
ENSP00000559804
resolver
ensp
ENSP00000559806
resolver
ensp
ENSP00000559809
resolver
ensp
ENSP00000559811
resolver
ensp
ENSP00000666907
resolver
ensp
ENSP00000666908
resolver
ensp
ENSP00000666909
resolver
ensp
ENSP00000666910
resolver
enst
ENST00000542733
resolver
genesymbol
NTRK3
resolver
genesymbol_syn
TRKC
resolver
hgnc
HGNC:8033
resolver
uniprot
B7Z4C5
resolver
uniprot
B7Z7U4
resolver
uniprot
E9PG56
resolver
uniprot
F6W9M4
resolver
uniprot
H0YND1
resolver
uniprot
O75682
resolver
uniprot
O95193
resolver
uniprot
Q12827
resolver
uniprot
Q16289
resolver
uniprot
Q96CY4
resolver
uniprot
X5D2R1
resolver
uniprot
X5D7M5
resolver
uniprot
X5DNW6
resolver
uniprot_entry
B7Z7U4_HUMAN
resolver
uniprot_entry
F6W9M4_HUMAN
resolver
uniprot_entry
NTRK3_HUMAN
resolver
uniprot_entry
O95193_HUMAN
resolver
uniprot_entry
Q96CY4_HUMAN
resolver
uniprot_entry
X5D2R1_HUMAN
resolver
uniprot_entry
X5D7M5_HUMAN
resolver
uniprot_entry
X5DNW6_HUMAN
resolver
uniprot_sec
B7Z4C5
resolver
uniprot_sec
E9PG56
resolver
uniprot_sec
H0YND1
resolver
uniprot_sec
O75682
resolver
uniprot_sec
Q12827
resolver
uniprot_sec
Q16289
resolver
amino_acid_sequence
MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in NTRK3 are associated with susceptibility to congenital heart defects (CHD). A disease characterized by congenital developmental abnormalities involving structures of the heart. CHD are the most common major birth defects and the leading cause of death from congenital malformations. {ECO:0000269|PubMed:25196463}.
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation. {ECO:0000269|PubMed:25196463}.
uniprot
proteins
mass_dalton
94428
uniprot
proteins
mutagenesis
MUTAGEN 572; /note="K->N: Loss of autophosphorylation and loss of NTRK3 signaling."; /evidence="ECO:0000269|PubMed:25196463
uniprot
proteins
post_translational_modification
PTM: Ligand-mediated auto-phosphorylation.
uniprot
proteins
protein_family
Insulin receptor subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
10388563
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18293376
uniprot
proteins
pubmed
25196463
uniprot
proteins
pubmed
25385546
uniprot
proteins
pubmed
7806211
uniprot
proteins
pubmed
7823156
uniprot
proteins
pubmed
9778053
uniprot
proteins
sequence_length
839
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 430..453; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins