DRAM1
entrez
55332
canonical
uniprot
Q8N682
canonical
ensembl
ENSG00000136048
resolver
ensp
ENSP00000258534
resolver
ensp
ENSP00000528832
resolver
ensp
ENSP00000528833
resolver
genesymbol
DRAM1
resolver
genesymbol_syn
DRAM
resolver
hgnc
HGNC:25645
resolver
uniprot
B7Z4T0
resolver
uniprot
Q7L3E3
resolver
uniprot
Q9NUN1
resolver
uniprot_entry
DRAM1_HUMAN
resolver
uniprot_sec
B7Z4T0
resolver
uniprot_sec
Q7L3E3
resolver
uniprot_sec
Q9NUN1
resolver
amino_acid_sequence
MLCFLRGMAFVPFLLVTWSSAAFIISYVVAVLSGHVNPFLPYISDTGTTPPESGIFGFMINFSAFLGAATMYTRYKIVQKQNQTCYFSTPVFNLVSLVLGLVGCFGMGIVANFQELAVPVVHDGGALLAFVCGVVYTLLQSIISYKSCPQWNSLSTCHIRMVISAVSCAAVIPMIVCASLISITKLEWNPREKDYVYHVVSAICEWTVAFGFIFYFLTFIQDFQSVTLRISTEINGDI
uniprot
proteins
function
FUNCTION: Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy. {ECO:0000269|PubMed:16839881, ECO:0000269|PubMed:17304243}.
uniprot
proteins
mass_dalton
26253
uniprot
proteins
protein_family
DRAM/TMEM150 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
16839881
uniprot
proteins
pubmed
17304243
uniprot
proteins
sequence_length
238
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:16839881}; Multi-pass membrane protein {ECO:0000269|PubMed:16839881}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 53..73; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 91..111; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 116..136; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 161..181; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 200..220; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins