TAOK1
entrez
57551
canonical
uniprot
Q7L7X3
canonical
ensembl
ENSG00000160551
resolver
ensp
ENSP00000261716
resolver
ensp
ENSP00000438819
resolver
genesymbol
TAOK1
resolver
genesymbol_syn
KIAA1361
resolver
genesymbol_syn
MAP3K16
resolver
genesymbol_syn
MARKK
resolver
hgnc
HGNC:29259
resolver
uniprot
A2RUT8
resolver
uniprot
B7ZLV6
resolver
uniprot
Q96L75
resolver
uniprot
Q9H2K7
resolver
uniprot
Q9H7S5
resolver
uniprot
Q9P2I6
resolver
uniprot_entry
TAOK1_HUMAN
resolver
uniprot_sec
A2RUT8
resolver
uniprot_sec
B7ZLV6
resolver
uniprot_sec
Q96L75
resolver
uniprot_sec
Q9H2K7
resolver
uniprot_sec
Q9H7S5
resolver
uniprot_sec
Q9P2I6
resolver
activity_regulation
ACTIVITY REGULATION: Serine/threonine-protein kinase activity is inhibited by SPRED1.
uniprot
proteins
amino_acid_sequence
MPSTNRAGSLKDPEIAELFFKEDPEKLFTDLREIGHGSFGAVYFARDVRTNEVVAIKKMSYSGKQSTEKWQDIIKEVKFLQRIKHPNSIEYKGCYLREHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALQGLAYLHSHTMIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHIAQNESPTLQSNEWSDYFRNFVDSCLQKIPQDRPTSEELLKHIFVLRERPETVLIDLIQRTKDAVRELDNLQYRKMKKLLFQEAHNGPAVEAQEEEEEQDHGVGRTGTVNSVGSNQSIPSMSISASSQSSSVNSLPDVSDDKSELDMMEGDHTVMSNSSVIHLKPEEENYREEGDPRTRASDPQSPPQVSRHKSHYRNREHFATIRTASLVTRQMQEHEQDSELREQMSGYKRMRRQHQKQLMTLENKLKAEMDEHRLRLDKDLETQRNNFAAEMEKLIKKHQAAMEKEAKVMSNEEKKFQQHIQAQQKKELNSFLESQKREYKLRKEQLKEELNENQSTPKKEKQEWLSKQKENIQHFQAEEEANLLRRQRQYLELECRRFKRRMLLGRHNLEQDLVREELNKRQTQKDLEHAMLLRQHESMQELEFRHLNTIQKMRCELIRLQHQTELTNQLEYNKRRERELRRKHVMEVRQQPKSLKSKELQIKKQFQDTCKIQTRQYKALRNHLLETTPKSEHKAVLKRLKEEQTRKLAILAEQYDHSINEMLSTQALRLDEAQEAECQVLKMQLQQELELLNAYQSKIKMQAEAQHDRELRELEQRVSLRRALLEQKIEEEMLALQNERTERIRSLLERQAREIEAFDSESMRLGFSNMVLSNLSPEAFSHSYPGASGWSHNPTGGPGPHWGHPMGGPPQAWGHPMQGGPQPWGHPSGPMQGVPRGSSMGVRNSPQALRRTASGGRTEQGMSRSTSVTSQISNGSHMSYT
uniprot
proteins
disease_involvement
DISEASE: Developmental delay with or without intellectual impairment or behavioral abnormalities (DDIB) [MIM:619575]: An autosomal dominant disorder characterized by a highly variable phenotype of developmental delay, intellectual disability, learning or behavioral problems, muscular hypotonia, and neonatal feeding difficulties. {ECO:0000269|PubMed:31230721, ECO:0000269|PubMed:33565190}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G protein-coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade. Plays an essential role in the regulation of neuronal development in the central nervous system (PubMed:33565190). Also plays a role in the regulation of neuronal migration to the cortical plate (By similarity). {ECO:0000250|UniProtKB:Q5F2E8, ECO:0000269|PubMed:12665513, ECO:0000269|PubMed:13679851, ECO:0000269|PubMed:16407310, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:17900936, ECO:0000269|PubMed:33565190}.
uniprot
proteins
mass_dalton
116070
uniprot
proteins
mutagenesis
MUTAGEN 57; /note="K->A: Abolishes kinase activity, ability to activate the MAPK8/JNK cascade and cleavage by caspase-3 (CASP3)."; /evidence="ECO:0000269|PubMed:16407310"; MUTAGEN 169; /note="D->A: Loss of serine/threonine-protein kinase activity."; /evidence="ECO:0000269|PubMed:17396146"; MUTAGEN 376; /note="D->N: Does not abolish cleavage by caspase-3 (CASP3)."; /evidence="ECO:0000269|PubMed:16407310"; MUTAGEN 643; /note="T->A: Abolishes phosphorylation by ATM; when associated with A-785 and A-990."; /evidence="ECO:0000269|PubMed:17396146"; MUTAGEN 785; /note="T->A: Abolishes phosphorylation by ATM; when associated with A-643 and A-990."; /evidence="ECO:0000269|PubMed:17396146"; MUTAGEN 990; /note="S->A: Abolishes phosphorylation by ATM; when associated with A-643 and A-785."; /evidence="ECO:0000269|PubMed:17396146
uniprot
proteins
post_translational_modification
PTM: Proteolytically processed by caspase-3 (CASP3). {ECO:0000269|PubMed:16407310}.; PTM: Autophosphorylated (By similarity). Phosphorylated by ATM in response to DNA damage. Phosphorylated by LRRK2. {ECO:0000250, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:20949042}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
protein_family
STE20 subfamily
uniprot
proteins
pubmed
10718198
uniprot
proteins
pubmed
12665513
uniprot
proteins
pubmed
13679851
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16407310
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16893890
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17396146
uniprot
proteins
pubmed
17417629
uniprot
proteins
pubmed
17900936
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19904549
uniprot
proteins
pubmed
20162290
uniprot
proteins
pubmed
20949042
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
31230721
uniprot
proteins
pubmed
33565190
uniprot
proteins
pubmed
9786855
uniprot
proteins
sequence_length
1001
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:13679851}.
uniprot
proteins