MBD6
entrez
114785
canonical
uniprot
Q96DN6
canonical
ensembl
ENSG00000166987
resolver
ensp
ENSP00000347896
resolver
ensp
ENSP00000531073
resolver
ensp
ENSP00000531074
resolver
enst
ENST00000355673
resolver
enst
ENST00000861014
resolver
enst
ENST00000861015
resolver
genesymbol
MBD6
resolver
genesymbol_syn
KIAA1887
resolver
hgnc
HGNC:20445
resolver
uniprot
Q6P0P0
resolver
uniprot
Q8N3M0
resolver
uniprot
Q8NA81
resolver
uniprot
Q96Q00
resolver
uniprot_entry
MBD6_HUMAN
resolver
uniprot_entry
Q6P0P0_HUMAN
resolver
uniprot_sec
Q8N3M0
resolver
uniprot_sec
Q8NA81
resolver
uniprot_sec
Q96Q00
resolver
amino_acid_sequence
MNGGNESSGADRAGGPVATSVPIGWQRCVREGAVLYISPSGTELSSLEQTRSYLLSDGTCKCGLECPLNVPKVFNFDPLAPVTPGGAGVGPASEEDMTKLCNHRRKAVAMATLYRSMETTCSHSSPGEGASPQMFHTVSPGPPSARPPCRVPPTTPLNGGPGSLPPEPPSVSQAFPTLAGPGGLFPPRLADPVPSGGSSSPRFLPRGNAPSPAPPPPPAISLNAPSYNWGAALRSSLVPSDLGSPPAPHASSSPPSDPPLFHCSDALTPPPLPPSNNLPAHPGPASQPPVSSATMHLPLVLGPLGGAPTVEGPGAPPFLASSLLSAAAKAQHPPLPPPSTLQGRRPRAQAPSASHSSSLRPSQRRPRRPPTVFRLLEGRGPQTPRRSRPRAPAPVPQPFSLPEPSQPILPSVLSLLGLPTPGPSHSDGSFNLLGSDAHLPPPPTLSSGSPPQPRHPIQPSLPGTTSGSLSSVPGAPAPPAASKAPVVPSPVLQSPSEGLGMGAGPACPLPPLAGGEAFPFPSPEQGLALSGAGFPGMLGALPLPLSLGQPPPSPLLNHSLFGVLTGGGGQPPPEPLLPPPGGPGPPLAPGEPEGPSLLVASLLPPPPSDLLPPPSAPPSNLLASFLPLLALGPTAGDGEGSAEGAGGPSGEPFSGLGDLSPLLFPPLSAPPTLIALNSALLAATLDPPSGTPPQPCVLSAPQPGPPTSSVTTATTDPGASSLGKAPSNSGRPPQLLSPLLGASLLGDLSSLTSSPGALPSLLQPPGPLLSGQLGLQLLPGGGAPPPLSEASSPLACLLQSLQIPPEQPEAPCLPPESPASALEPEPARPPLSALAPPHGSPDPPVPELLTGRGSGKRGRRGGGGLRGINGEARPARGRKPGSRREPGRLALKWGTRGGFNGQMERSPRRTHHWQHNGELAEGGAEPKDPPPPGPHSEDLKVPPGVVRKSRRGRRRKYNPTRNSNSSRQDITLEPSPTARAAVPLPPRARPGRPAKNKRRKLAP
uniprot
proteins
function
FUNCTION: Non-catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1) (PubMed:24634419). Important for stability of PR-DUB components and stimulating its ubiquitinase activity (PubMed:36180891). As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3 (PubMed:36180891). MBD5 and MBD6 containing complexes associate with distinct chromatin regions enriched in genes involved in different pathways (PubMed:36180891). Heterochromatin recruitment is not mediated by DNA methylation (PubMed:20700456). The PR-DUB complex is an epigenetic regulator of gene expression, including genes involved in development, cell communication, signaling, cell proliferation and cell viability; may promote cancer cell growth (PubMed:36180891). {ECO:0000269|PubMed:20700456, ECO:0000269|PubMed:24634419, ECO:0000269|PubMed:36180891}.
uniprot
proteins
mass_dalton
101201
uniprot
proteins
mutagenesis
MUTAGEN 61; /note="K->A: Disrupts interaction with ASXL1/2/3; when associated with A-66."; /evidence="ECO:0000269|PubMed:36180891"; MUTAGEN 66; /note="C->A: Disrupts interaction with ASXL1/2/3; when associated with A-61."; /evidence="ECO:0000269|PubMed:36180891
uniprot
proteins
pubmed
11572484
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
20700456
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24634419
uniprot
proteins
pubmed
36180891
uniprot
proteins
sequence_length
1003
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20700456, ECO:0000269|PubMed:24634419}. Chromosome {ECO:0000269|PubMed:20700456, ECO:0000269|PubMed:24634419}. Note=Associates with heterochromatin containing chromocentres in a subset of cells in a DNA methylation-independent manner (PubMed:20700456). Localizes to sites of DNA damage independent of the PR-DUB complex (PubMed:24634419). {ECO:0000269|PubMed:20700456, ECO:0000269|PubMed:24634419}.
uniprot
proteins