Dedd
entrez
83631
canonical
uniprot
Q9Z2K0
canonical
ensembl
ENSRNOG00000003779
resolver
ensembl
ENSRNOG00055022296
resolver
ensembl
ENSRNOG00060017425
resolver
ensembl
ENSRNOG00065022384
resolver
ensp
ENSRNOP00000005147
resolver
ensp
ENSRNOP00055031194
resolver
ensp
ENSRNOP00060023985
resolver
ensp
ENSRNOP00065030908
resolver
enst
ENSRNOT00000005147
resolver
enst
ENSRNOT00055038315
resolver
enst
ENSRNOT00060029768
resolver
enst
ENSRNOT00065038175
resolver
genesymbol
Dedd
resolver
genesymbol_syn
Deft
resolver
uniprot_entry
DEDD_RAT
resolver
amino_acid_sequence
MAGLKRRASQVWPEERVEQEHGLYSLHRMFDIVGTHLTHRDVRVLSFLFVDVIDDHERGLIRNGRDFLLALERQGRCDESNFRQVLQLLRIITRHDLLPYVTLKKRRAVCPDLVDKYLEETSIRYVTPRALSDPEPRPPQPSKTVPPHYPVVCCPTSGSQMCSKRPARGRTTLGSQRKRRKSVTPDPKEKQTCDIRLRVRAEYCQHETALQGNVFSNKQDPLERQFERFNQANTILKSRDLGSIICDIKFSELTYLDAFWRDYINGSLLEALKGVFITDSLKQAVGHEAIKLLVNVDEEDYELGRQKLLRNLMLQALP
uniprot
proteins
function
FUNCTION: A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3. Inhibits DNA transcription in vitro (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
36847
uniprot
proteins
post_translational_modification
PTM: Exists predominantly in a mono- or diubiquitinated form.
uniprot
proteins
pubmed
9832420
uniprot
proteins
sequence_length
318
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli. Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells (By similarity). {ECO:0000250}.
uniprot
proteins