Clcn1
entrez
25688
canonical
uniprot
P35524
canonical
ensembl
ENSRNOG00000016917
resolver
ensembl
ENSRNOG00055028197
resolver
ensembl
ENSRNOG00060008655
resolver
ensembl
ENSRNOG00065016057
resolver
ensp
ENSRNOP00000043372
resolver
ensp
ENSRNOP00000103689
resolver
ensp
ENSRNOP00055040096
resolver
ensp
ENSRNOP00060011113
resolver
ensp
ENSRNOP00065020934
resolver
enst
ENSRNOT00000144769
resolver
enst
ENSRNOT00055048785
resolver
enst
ENSRNOT00060014449
resolver
enst
ENSRNOT00065026687
resolver
genesymbol
Clcn1
resolver
uniprot
A0ABK0LE59
resolver
uniprot_entry
A0ABK0LE59_RAT
resolver
uniprot_entry
CLCN1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Modulated by membrane voltage with depolarization favouring channel opening and hyperpolarization favouring channel closure. Inhibited by acidic pH and ATP binding due to a shift of voltage dependence of common gating to more positive voltages. Inhibited by 9-anthracene-carboxylic acid. {ECO:0000250|UniProtKB:P35523, ECO:0000269|PubMed:1659664}.
uniprot
proteins
amino_acid_sequence
MERSQSQQHGGEQSWWGTAPQYQYMPFEHCTSYGLPSENGGLQHRPRKDLGPRHNAHPTQIYGHHKEQYSYQAQDRGIPKKTDSSSTVDSLDEDHYSKCQDCVHRLGRVLRRKLGEDWIFLVLLGLLMALVSWCMDYVSAKSLQAYKWTYAQMQPSLPLQYLAWVTFPLILILFSALFCQLISPQAVGSGIPEMKTILRGVVLKEYLTLKAFVAKVVALTAGLGSGIPVGKEGPFVHIASICAAVLSKFMSMFSGVYEQPYYYTDILTVGCAVGVGCCFGTPLGGVLFSIEVTSTYFAVRNYWRGFFAATFSAFVFRVLAVWNKDAVTITALFRTNFRMDFPFDLKELPAFAVIGICCGFLGAVFVYLHRQVMLGVRKHKALSQFLAKHRLLYPGIVTFVIASLTFPPGMGQFMAGELMPREAISTLFDNNTWVKHIGDPKSLGQSAVWIHPQVNVVIIILLFFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVGEIMAMLFPEGILFDDIIYKILPGGYAVIGAAALTGAVSHTVSTAVICFELTGQIAHILPMMVAVILANMVAQSLQPSLYDSIIQVKKLPYLPDLGWNQLSKFTIFVEDIMVRDVKFVSASCTYGELRNLLQTTTVKTLPLVDSKDSMILLGSVERSELQSLLQRHLCAERRLKAAQDMARKLSELPYNGQAQLAGEWHPGGRPESFAFVDEDEDEDVSRKTELPQTPTPPPPPPPPLPPQFPIAPSYPEEPNGPLPSHKQPPEASDSADQRSSIFQRLLHCLLGKAHSTKKKITQDSTDLVDNMSPEEIEAWEREQLSQPVCFDFCCIDQSPFQLVEQTTLHKTHTLFSLLGLHLAYVTSMGKLRGVLALEELQKAIKGHTKSGVQLRPPLASFRNTTSIRKTPGGPPPPAESWNVPEGEDGAPEREVMVPTMPETPVPPPSPEVPSCLAPARVEGELEELEMVGNLGPEEDLADILHGPSLRSTDEEDEDELIL
uniprot
proteins
function
FUNCTION: Voltage-gated chloride channel involved in skeletal muscle excitability. Generates most of the plasma membrane chloride conductance in skeletal muscle fibers, stabilizes the resting membrane potential and contributes to the repolarization phase during action potential firing (By similarity) (PubMed:1659664, PubMed:9565403). Forms a homodimeric channel where each subunit has its own ion conduction pathway. Conducts double-barreled currents controlled by two types of gates, two fast glutamate gates that control each subunit independently and a slow common gate that opens and shuts off both subunits simultaneously. Has a significant open probability at muscle resting potential and is further activated upon membrane depolarization (By similarity). Permeable to small monovalent anions with ion selectivity for chloride > thiocyanate > bromide > nitrate > iodide (PubMed:1659664, PubMed:9565403). {ECO:0000250|UniProtKB:P35523, ECO:0000269|PubMed:1659664, ECO:0000269|PubMed:9565403}.
uniprot
proteins
mass_dalton
110073
uniprot
proteins
protein_family
Chloride channel (TC 2.A.49) family
uniprot
proteins
protein_family
ClC-1/CLCN1 subfamily
uniprot
proteins
pubmed
1659664
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9565403
uniprot
proteins
sequence_length
994
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1659664}; Multi-pass membrane protein {ECO:0000255}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q64347}; Multi-pass membrane protein {ECO:0000255}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:Q64347}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 119..150; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 159..179; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 302..321; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 348..376; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 391..408; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523
uniprot
proteins