MAOB
entrez
4129
canonical
uniprot
P27338
canonical
ensembl
ENSG00000069535
resolver
ensp
ENSP00000367309
resolver
genesymbol
MAOB
resolver
hgnc
HGNC:6834
resolver
uniprot
B2R6R3
resolver
uniprot
B7Z242
resolver
uniprot
B7Z5H3
resolver
uniprot
D3DWC3
resolver
uniprot
Q7Z6S2
resolver
uniprot_entry
AOFB_HUMAN
resolver
uniprot_entry
B7Z242_HUMAN
resolver
uniprot_sec
B2R6R3
resolver
uniprot_sec
B7Z5H3
resolver
uniprot_sec
D3DWC3
resolver
uniprot_sec
Q7Z6S2
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by deprenyl. {ECO:0000269|PubMed:11134050, ECO:0000269|PubMed:20493079}.
uniprot
proteins
amino_acid_sequence
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
uniprot
proteins
ec_number
1.4.3.21
uniprot
proteins
ec_number
1.4.3.4
uniprot
proteins
function
FUNCTION: Catalyzes the oxidative deamination of primary and some secondary amines such as neurotransmitters, and exogenous amines including the tertiary amine, neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), with concomitant reduction of oxygen to hydrogen peroxide and participates in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:11049757, PubMed:11134050, PubMed:20493079, PubMed:8316221, PubMed:8665924). Preferentially degrades benzylamine and phenylethylamine (PubMed:11049757, PubMed:11134050, PubMed:20493079, PubMed:8316221, PubMed:8665924). {ECO:0000269|PubMed:11049757, ECO:0000269|PubMed:11134050, ECO:0000269|PubMed:20493079, ECO:0000269|PubMed:8316221, ECO:0000269|PubMed:8665924}.
uniprot
proteins
mass_dalton
58763
uniprot
proteins
mutagenesis
MUTAGEN 5; /note="C->S: No loss of activity."; /evidence="ECO:0000269|PubMed:8316221"; MUTAGEN 156; /note="C->S: Complete loss of activity."; /evidence="ECO:0000269|PubMed:8316221"; MUTAGEN 158; /note="T->A: Dramatic loss of activity."; /evidence="ECO:0000269|PubMed:8665924"; MUTAGEN 172; /note="C->S: No loss of activity."; /evidence="ECO:0000269|PubMed:8316221"; MUTAGEN 192; /note="C->S: No loss of activity."; /evidence="ECO:0000269|PubMed:8316221"; MUTAGEN 199; /note="I->F: Alters specificity towards synthetic inhibitors."; MUTAGEN 297; /note="C->S: No loss of activity."; /evidence="ECO:0000269|PubMed:8316221"; MUTAGEN 312; /note="C->S: No loss of activity."; /evidence="ECO:0000269|PubMed:8316221"; MUTAGEN 365; /note="C->S: Complete loss of activity."; /evidence="ECO:0000269|PubMed:8316221"; MUTAGEN 382; /note="H->R: Significant loss of activity."; /evidence="ECO:0000269|PubMed:8665924"; MUTAGEN 386; /note="K->M: No loss of activity."; /evidence="ECO:0000269|PubMed:8665924"; MUTAGEN 389; /note="C->A: Complete loss of activity."; /evidence="ECO:0000269|PubMed:8316221, ECO:0000269|PubMed:8665924"; MUTAGEN 389; /note="C->S: No loss of activity."; /evidence="ECO:0000269|PubMed:8316221, ECO:0000269|PubMed:8665924"; MUTAGEN 394; /note="S->A: No loss of activity."; /evidence="ECO:0000269|PubMed:8665924"; MUTAGEN 397; /note="C->S: Complete loss of activity."; /evidence="ECO:0000269|PubMed:8316221
uniprot
proteins
protein_family
Flavin monoamine oxidase family
uniprot
proteins
pubmed
11049757
uniprot
proteins
pubmed
11134050
uniprot
proteins
pubmed
11753429
uniprot
proteins
pubmed
12913124
uniprot
proteins
pubmed
1432104
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15027868
uniprot
proteins
pubmed
15710600
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
16366596
uniprot
proteins
pubmed
2023912
uniprot
proteins
pubmed
20493079
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
3387449
uniprot
proteins
pubmed
8316221
uniprot
proteins
pubmed
8515265
uniprot
proteins
pubmed
8665924
uniprot
proteins
sequence_length
520
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.
uniprot
proteins
transmembrane_region
TRANSMEM 490..516; /note="Helical; Anchor for type IV membrane protein
uniprot
proteins