Mark2
entrez
13728
canonical
uniprot
Q05512
canonical
ensembl
ENSMUSG00000024969
resolver
ensp
ENSMUSP00000025921
resolver
ensp
ENSMUSP00000032557
resolver
ensp
ENSMUSP00000126468
resolver
ensp
ENSMUSP00000127827
resolver
ensp
ENSMUSP00000129506
resolver
ensp
ENSMUSP00000131684
resolver
ensp
ENSMUSP00000184385
resolver
ensp
ENSMUSP00000184386
resolver
ensp
ENSMUSP00000184388
resolver
ensp
ENSMUSP00000184401
resolver
enst
ENSMUST00000025921
resolver
enst
ENSMUST00000032557
resolver
enst
ENSMUST00000164205
resolver
enst
ENSMUST00000165286
resolver
enst
ENSMUST00000165965
resolver
genesymbol
Mark2
resolver
genesymbol_syn
Emk
resolver
uniprot
A0A0R4J0B1
resolver
uniprot
A0A0R4J227
resolver
uniprot
E9PWB5
resolver
uniprot
E9PYX3
resolver
uniprot
E9QMP6
resolver
uniprot
F6PZT7
resolver
uniprot
Q3T9A3
resolver
uniprot
Q3T9L3
resolver
uniprot
Q6PDR4
resolver
uniprot
Q8BR95
resolver
uniprot_entry
A0A0R4J0B1_MOUSE
resolver
uniprot_entry
A0A0R4J227_MOUSE
resolver
uniprot_entry
E9PYX3_MOUSE
resolver
uniprot_entry
E9QMP6_MOUSE
resolver
uniprot_entry
F6PZT7_MOUSE
resolver
uniprot_entry
MARK2_MOUSE
resolver
uniprot_entry
Q3T9A3_MOUSE
resolver
uniprot_sec
E9PWB5
resolver
uniprot_sec
Q3T9L3
resolver
uniprot_sec
Q6PDR4
resolver
uniprot_sec
Q8BR95
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by PAK5; inhibition is independent of the kinase activity of PAK5. Activated by phosphorylation on Thr-208. Inhibited by phosphorylation at Ser-212 and Thr-593. Inhibited by hymenialdisine (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMLRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKIDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRSSDQAVPAIPTSNSYSKKTQSNNAENKRPEEETGRKASSTAKVPASPLPGLDRKKTTPAPSTNSVLSTSTNRSRNSPLLDRASLGQASIQNGKDSLTMPGSRASTASASAAVSAARPRQHQKSMSASVHPNKASGLPPTESNCEVPRPSTAPQRVPVASPSAHNISSSSGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPYGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLNEPESKDRVETLRPHVVGSGGTDKDKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHERYMLLCVHGTPGHENFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
ec_number
2.7.11.26
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of disheveled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. Phosphorylates UBAC2 at 'Ser-223' during ER stress or starvation-induced autophagy, promoting UBAC2 dimerization and interaction with GABARAP to mediate ER-phagy. {ECO:0000250|UniProtKB:Q7KZI7}.
uniprot
proteins
mass_dalton
86306
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. Phosphorylated at Thr-208 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-208 by TAOK1 activates the kinase activity, leading to phosphorylation and detachment of MAPT/TAU from microtubules. Phosphorylation at Ser-212 by GSK3-beta (GSK3B) inhibits the kinase activity. Phosphorylation by CaMK1 promotes activity and is required to promote neurite outgrowth. Phosphorylation at Thr-593 by PRKCZ/aPKC in polarized epithelial cells inhibits the kinase activity and promotes binding to 14-3-3 protein YWHAZ, leading to relocation from cell membrane to cytoplasm (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
SNF1 subfamily
uniprot
proteins
pubmed
10491259
uniprot
proteins
pubmed
11287624
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17372192
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8358177
uniprot
proteins
sequence_length
776
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Lateral cell membrane {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q7KZI7}. Cytoplasm {ECO:0000250|UniProtKB:Q7KZI7}. Note=Phosphorylation at Thr-593 by PRKCZ/aPKC and subsequent interaction with 14-3-3 protein YWHAZ promotes relocation from the cell membrane to the cytoplasm. {ECO:0000250}.
uniprot
proteins