MST065
entrez
56993
canonical
uniprot
Q9NS69
canonical
ensembl
ENSG00000100216
resolver
ensp
ENSP00000216034
resolver
enst
ENST00000216034
resolver
genesymbol
MST065
resolver
genesymbol
TOMM22
resolver
genesymbol_syn
TOM22
resolver
hgnc
HGNC:18002
resolver
uniprot
Q549C5
resolver
uniprot_entry
Q549C5_HUMAN
resolver
uniprot_entry
TOM22_HUMAN
resolver
amino_acid_sequence
MAAAVAAAGAGEPQSPDELLPKGDAEKPEEELEEDDDEELDETLSERLWGLTEMFPERVRSAAGATFDLSLFVAQKMYRFSRAALWIGTTSFMILVLPVVFETEKLQMEQQQQLQQRQILLGPNTGLSGGMPGALPSLPGKI
uniprot
proteins
function
FUNCTION: Central receptor component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (PubMed:40080546). Together with the peripheral receptor TOMM20, functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore (PubMed:10982837). The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (PubMed:40080546). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases (By similarity). {ECO:0000250|UniProtKB:Q75Q41, ECO:0000269|PubMed:10982837, ECO:0000269|PubMed:40080546}.
uniprot
proteins
mass_dalton
15522
uniprot
proteins
protein_family
Tom22 family
uniprot
proteins
pubmed
10900208
uniprot
proteins
pubmed
10982837
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18331822
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
40080546
uniprot
proteins
sequence_length
142
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:10982837}; Single-pass membrane protein {ECO:0000269|PubMed:10982837, ECO:0000269|PubMed:40080546}.
uniprot
proteins
transmembrane_region
TRANSMEM 84..103; /note="Helical"; /evidence="ECO:0000269|PubMed:40080546, ECO:0007744|PDB:9EIH, ECO:0007744|PDB:9EII, ECO:0007744|PDB:9EIJ
uniprot
proteins