GPS1
entrez
2873
canonical
uniprot
Q13098
canonical
ensembl
ENSG00000169727
resolver
ensp
ENSP00000302873
resolver
ensp
ENSP00000313569
resolver
ensp
ENSP00000376167
resolver
ensp
ENSP00000462265
resolver
ensp
ENSP00000485035
resolver
ensp
ENSP00000485330
resolver
ensp
ENSP00000485641
resolver
ensp
ENSP00000516490
resolver
ensp
ENSP00000516491
resolver
ensp
ENSP00000521022
resolver
ensp
ENSP00000579729
resolver
ensp
ENSP00000579733
resolver
ensp
ENSP00000579736
resolver
ensp
ENSP00000579739
resolver
ensp
ENSP00000623829
resolver
ensp
ENSP00000623833
resolver
ensp
ENSP00000687827
resolver
ensp
ENSP00000687831
resolver
ensp
ENSP00000687839
resolver
ensp
ENSP00000687840
resolver
enst
ENST00000320548
resolver
enst
ENST00000583486
resolver
enst
ENST00000623691
resolver
enst
ENST00000623761
resolver
enst
ENST00000624957
resolver
enst
ENST00000706669
resolver
enst
ENST00000706670
resolver
genesymbol
GPS1
resolver
genesymbol_syn
COPS1
resolver
genesymbol_syn
CSN1
resolver
hgnc
HGNC:4549
resolver
uniprot
A0A096LNH8
resolver
uniprot
A0A096LP07
resolver
uniprot
A0A096LPJ3
resolver
uniprot
A0A9L9PX62
resolver
uniprot
A0A9L9PXT0
resolver
uniprot
A0ABJ7H8D6
resolver
uniprot
A8K070
resolver
uniprot
C9JFE4
resolver
uniprot
Q8NA10
resolver
uniprot
Q9BWL1
resolver
uniprot_entry
A0A096LNH8_HUMAN
resolver
uniprot_entry
A0A096LP07_HUMAN
resolver
uniprot_entry
A0A096LPJ3_HUMAN
resolver
uniprot_entry
A0A9L9PX62_HUMAN
resolver
uniprot_entry
A0A9L9PXT0_HUMAN
resolver
uniprot_entry
A0ABJ7H8D6_HUMAN
resolver
uniprot_entry
A8K070_HUMAN
resolver
uniprot_entry
C9JFE4_HUMAN
resolver
uniprot_entry
CSN1_HUMAN
resolver
uniprot_sec
Q8NA10
resolver
uniprot_sec
Q9BWL1
resolver
amino_acid_sequence
MPLPVQVFNLQGAVEPMQIDVDPQEDPQNAPDVNYVVENPSLDLEQYAASYSGLMRIERLQFIADHCPTLRVEALKMALSFVQRTFNVDMYEEIHRKLSEATRSSLRELQNAPDAIPESGVEPPALDTAWVEATRKKALLKLEKLDTDLKNYKGNSIKESIRRGHDDLGDHYLDCGDLSNALKCYSRARDYCTSAKHVINMCLNVIKVSVYLQNWSHVLSYVSKAESTPEIAEQRGERDSQTQAILTKLKCAAGLAELAARKYKQAAKCLLLASFDHCDFPELLSPSNVAIYGGLCALATFDRQELQRNVISSSSFKLFLELEPQVRDIIFKFYESKYASCLKMLDEMKDNLLLDMYLAPHVRTLYTQIRNRALIQYFSPYVSADMHRMAAAFNTTVAALEDELTQLILEGLISARVDSHSKILYARDVDQRSTTFEKSLLMGKEFQRRAKAMMLRAAVLRNQIHVKSPPREGSQGELTPANSQSRMSTNM
uniprot
proteins
function
FUNCTION: Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G protein- and mitogen-activated protein kinase-mediated signal transduction. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.
uniprot
proteins
mass_dalton
55537
uniprot
proteins
protein_family
CSN1 family
uniprot
proteins
pubmed
11114242
uniprot
proteins
pubmed
11285227
uniprot
proteins
pubmed
11337588
uniprot
proteins
pubmed
12324474
uniprot
proteins
pubmed
12628923
uniprot
proteins
pubmed
12732143
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18850735
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26456823
uniprot
proteins
pubmed
35913642
uniprot
proteins
pubmed
8943324
uniprot
proteins
pubmed
9535219
uniprot
proteins
sequence_length
491
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}.
uniprot
proteins