Trim39
entrez
309591
canonical
uniprot
Q6MFZ5
canonical
ensembl
ENSRNOG00000000785
resolver
ensembl
ENSRNOG00055009162
resolver
ensembl
ENSRNOG00060003475
resolver
ensembl
ENSRNOG00065029568
resolver
ensp
ENSRNOP00000098163
resolver
ensp
ENSRNOP00055012419
resolver
ensp
ENSRNOP00060004161
resolver
ensp
ENSRNOP00065042001
resolver
enst
ENSRNOT00000120505
resolver
enst
ENSRNOT00055015504
resolver
enst
ENSRNOT00060005703
resolver
enst
ENSRNOT00065051056
resolver
genesymbol
Trim39
resolver
genesymbol_syn
Rnf23
resolver
uniprot_entry
TRI39_RAT
resolver
amino_acid_sequence
MAETSLLEAGASAASTAAALENLQVEASCSVCLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSRYRSLRPNRQLGSMVEIAKQLQTVKRKIRDESLCSQHHEPLSLFCYEDQEAVCLICAISHTHRAHTVVPMDDATQEYKEKLQKCLEPLEQKLQEITCCKASEERKPGELKRLVESRRQQILKEFEELHRRLDEEQQTLLSRLEEEEQDILQRLRENAAHLGDRRRDLAHLAAEVEGKCLQSGFEMLKDVKSTLEKCEKVKTMEVTSVSIELEKNFSHFPRQYFALRKILKQLIADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPQRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTPLPETGYWRVRLWNGDKYAATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFTEKLWPLFYPGIRAGRKNAAPLTIRPPTDWE
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase (By similarity). May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1 (By similarity). Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21 (By similarity). Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation (By similarity). {ECO:0000250|UniProtKB:Q9HCM9}.
uniprot
proteins
mass_dalton
56394
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. {ECO:0000250|UniProtKB:Q9HCM9}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
15060004
uniprot
proteins
sequence_length
488
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9HCM9}. Mitochondrion {ECO:0000250|UniProtKB:Q9HCM9}. Nucleus {ECO:0000250|UniProtKB:Q9HCM9}. Note=Found predominantly in the cytosol. Partial shift from the cytosol to the mitochondria when colocalized with MOAP1. Colocalizes with CDKN1A in the nucleus. {ECO:0000250|UniProtKB:Q9HCM9}.
uniprot
proteins