Agt
entrez
24179
canonical
uniprot
P01015
canonical
ensembl
ENSRNOG00000018445
resolver
ensp
ENSRNOP00000024917
resolver
ensp
ENSRNOP00000101947
resolver
enst
ENSRNOT00000024917
resolver
genesymbol
Agt
resolver
genesymbol_syn
Serpina8
resolver
uniprot
A0A8L2UK05
resolver
uniprot_entry
A0A8L2UK05_RAT
resolver
uniprot_entry
ANGT_RAT
resolver
amino_acid_sequence
MTPTGAGLKATIFCILTWVSLTAGDRVYIHPFHLLYYSKSTCAQLENPSVETLPEPTFEPVPIQAKTSPVDEKTLRDKLVLATEKLEAEDRQRAAQVAMIANFMGFRMYKMLSEARGVASGAVLSPPALFGTLVSFYLGSLDPTASQLQVLLGVPVKEGDCTSRLDGHKVLTALQAVQGLLVTQGGSSSQTPLLQSTVVGLFTAPGLRLKQPFVESLGPFTPAIFPRSLDLSTDPVLAAQKINRFVQAVTGWKMNLPLEGVSTDSTLFFNTYVHFQGKMRGFSQLTGLHEFWVDNSTSVSVPMLSGTGNFQHWSDAQNNFSVTRVPLGESVTLLLIQPQCASDLDRVEVLVFQHDFLTWIKNPPPRAIRLTLPQLEIRGSYNLQDLLAQAKLSTLLGAEANLGKMGDTNPRVGEVLNSILLELQAGEEEQPTESAQQPGSPEVLDVTLSSPFLFAIYERDSGALHFLGRVDNPQNVV
uniprot
proteins
function
FUNCTION: Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis. {ECO:0000250|UniProtKB:P01019}.; FUNCTION: [Angiotensin-2]: Acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone. Acts by binding to angiotensin receptors AGTR1 and AGTR2 (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (PubMed:9508787). {ECO:0000250|UniProtKB:P01019, ECO:0000269|PubMed:9508787}.; FUNCTION: [Angiotensin-3]: Stimulates aldosterone release. {ECO:0000250|UniProtKB:P01019}.; FUNCTION: [Angiotensin 1-7]: Is a ligand for the G protein-coupled receptor MAS1 (By similarity). Has vasodilator and antidiuretic effects (By similarity). Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets (PubMed:18026570). {ECO:0000250|UniProtKB:P11859, ECO:0000269|PubMed:18026570}.
uniprot
proteins
mass_dalton
51982
uniprot
proteins
post_translational_modification
PTM: In response to low blood pressure, the enzyme renin/REN cleaves angiotensinogen to produce angiotensin-1. Angiotensin-1 is a substrate of ACE (angiotensin converting enzyme) that removes a dipeptide to yield the physiologically active peptide angiotensin-2. Angiotensin-1 and angiotensin-2 can be further processed to generate angiotensin-3, angiotensin-4. Angiotensin 1-9 is cleaved from angiotensin-1 by ACE2 and can be further processed by ACE to produce angiotensin 1-7, angiotensin 1-5 and angiotensin 1-4. Angiotensin 1-7 has also been proposed to be cleaved from angiotensin-2 by ACE2 or from angiotensin-1 by MME (neprilysin) (By similarity). {ECO:0000250|UniProtKB:P01019}.; PTM: The disulfide bond is labile. Angiotensinogen is present in the circulation in a near 40:60 ratio with the oxidized disulfide-bonded form, which preferentially interacts with receptor-bound renin. {ECO:0000269|PubMed:20927107}.
uniprot
proteins
protein_family
Serpin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18026570
uniprot
proteins
pubmed
20927107
uniprot
proteins
pubmed
4344907
uniprot
proteins
pubmed
6330095
uniprot
proteins
pubmed
6572971
uniprot
proteins
pubmed
9508787
uniprot
proteins
sequence_length
477
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:4344907}.
uniprot
proteins