FMO3
entrez
2328
canonical
uniprot
P31513
canonical
ensembl
ENSG00000007933
resolver
ensp
ENSP00000356729
resolver
ensp
ENSP00000566208
resolver
ensp
ENSP00000566209
resolver
ensp
ENSP00000566210
resolver
ensp
ENSP00000566211
resolver
ensp
ENSP00000566213
resolver
ensp
ENSP00000566219
resolver
ensp
ENSP00000566220
resolver
ensp
ENSP00000566221
resolver
enst
ENST00000367755
resolver
enst
ENST00000896149
resolver
enst
ENST00000896150
resolver
enst
ENST00000896151
resolver
enst
ENST00000896152
resolver
enst
ENST00000896160
resolver
enst
ENST00000896161
resolver
enst
ENST00000896162
resolver
genesymbol
FMO3
resolver
hgnc
HGNC:3771
resolver
uniprot
A0A024R8Z4
resolver
uniprot
A0A0S2Z3T8
resolver
uniprot
B2R816
resolver
uniprot
B7Z3M2
resolver
uniprot
B7Z543
resolver
uniprot
Q14854
resolver
uniprot
Q53FW5
resolver
uniprot
Q8N5N5
resolver
uniprot_entry
A0A024R8Z4_HUMAN
resolver
uniprot_entry
B7Z3M2_HUMAN
resolver
uniprot_entry
B7Z543_HUMAN
resolver
uniprot_entry
FMO3_HUMAN
resolver
uniprot_entry
Q53FW5_HUMAN
resolver
uniprot_sec
A0A0S2Z3T8
resolver
uniprot_sec
B2R816
resolver
uniprot_sec
Q14854
resolver
uniprot_sec
Q8N5N5
resolver
amino_acid_sequence
MGKKVAIIGAGVSGLASIRSCLEEGLEPTCFEKSNDIGGLWKFSDHAEEGRASIYKSVFSNSSKEMMCFPDFPFPDDFPNFMHNSKIQEYIIAFAKEKNLLKYIQFKTFVSSVNKHPDFATTGQWDVTTERDGKKESAVFDAVMVCSGHHVYPNLPKESFPGLNHFKGKCFHSRDYKEPGVFNGKRVLVVGLGNSGCDIATELSRTAEQVMISSRSGSWVMSRVWDNGYPWDMLLVTRFGTFLKNNLPTAISDWLYVKQMNARFKHENYGLMPLNGVLRKEPVFNDELPASILCGIVSVKPNVKEFTETSAIFEDGTIFEGIDCVIFATGYSFAYPFLDESIIKSRNNEIILFKGVFPPLLEKSTIAVIGFVQSLGAAIPTVDLQSRWAAQVIKGTCTLPSMEDMMNDINEKMEKKRKWFGKSETIQTDYIVYMDELSSFIGAKPNIPWLFLTDPKLAMEVYFGPCSPYQFRLVGPGQWPGARNAILTQWDRSLKPMQTRVVGRLQKPCFFFHWLKLFAIPILLIAVFLVLT
uniprot
proteins
disease_involvement
DISEASE: Trimethylaminuria (TMAU) [MIM:602079]: Inborn error of metabolism associated with an offensive body odor and caused by deficiency of FMO-mediated N-oxidation of amino-trimethylamine (TMA) derived from foodstuffs. Affected individuals excrete relatively large amounts of TMA in their urine, sweat, and breath, and exhibit a fishy body odor characteristic of the malodorous free amine. {ECO:0000269|PubMed:10338091, ECO:0000269|PubMed:10479479, ECO:0000269|PubMed:11191884, ECO:0000269|PubMed:12893987, ECO:0000269|PubMed:17531949, ECO:0000269|PubMed:9536088}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
1.14.13.148
uniprot
proteins
ec_number
1.14.13.32
uniprot
proteins
ec_number
1.14.13.8
uniprot
proteins
function
FUNCTION: Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds (PubMed:10759686, PubMed:30381441, PubMed:32156684). Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite (PubMed:9776311). TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation (PubMed:29981269). {ECO:0000269|PubMed:10759686, ECO:0000269|PubMed:29981269, ECO:0000269|PubMed:30381441, ECO:0000269|PubMed:32156684, ECO:0000269|PubMed:9224773, ECO:0000269|PubMed:9776311}.
uniprot
proteins
mass_dalton
60033
uniprot
proteins
protein_family
FMO family
uniprot
proteins
pubmed
10338091
uniprot
proteins
pubmed
10479479
uniprot
proteins
pubmed
10759686
uniprot
proteins
pubmed
11191884
uniprot
proteins
pubmed
12527699
uniprot
proteins
pubmed
12893987
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
1542660
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15618753
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17050781
uniprot
proteins
pubmed
17531949
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29981269
uniprot
proteins
pubmed
30381441
uniprot
proteins
pubmed
32156684
uniprot
proteins
pubmed
8654418
uniprot
proteins
pubmed
9224773
uniprot
proteins
pubmed
9417913
uniprot
proteins
pubmed
9536088
uniprot
proteins
pubmed
9776311
uniprot
proteins
sequence_length
532
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000250|UniProtKB:P32417}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P32417}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 510..530; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins