CD19
entrez
930
canonical
uniprot
P15391
canonical
ensembl
ENSG00000177455
resolver
ensp
ENSP00000313419
resolver
ensp
ENSP00000437940
resolver
genesymbol
CD19
resolver
hgnc
HGNC:1633
resolver
uniprot
A0N0P9
resolver
uniprot
F5H635
resolver
uniprot
Q96S68
resolver
uniprot
Q9BRD6
resolver
uniprot_entry
CD19_HUMAN
resolver
uniprot_sec
A0N0P9
resolver
uniprot_sec
F5H635
resolver
uniprot_sec
Q96S68
resolver
uniprot_sec
Q9BRD6
resolver
amino_acid_sequence
MPPPRLLFFLLFLTPMEVRPEEPLVVKVEEGDNAVLQCLKGTSDGPTQQLTWSRESPLKPFLKLSLGLPGLGIHMRPLAIWLFIFNVSQQMGGFYLCQPGPPSEKAWQPGWTVNVEGSGELFRWNVSDLGGLGCGLKNRSSEGPSSPSGKLMSPKLYVWAKDRPEIWEGEPPCLPPRDSLNQSLSQDLTMAPGSTLWLSCGVPPDSVSRGPLSWTHVHPKGPKSLLSLELKDDRPARDMWVMETGLLLPRATAQDAGKYYCHRGNLTMSFHLEITARPVLWHWLLRTGGWKVSAVTLAYLIFCLCSLVGILHLQRALVLRRKRKRMTDPTRRFFKVTPPPGSGPQNQYGNVLSLPTPTSGLGRAQRWAAGLGGTAPSYGNPSSDVQADGALGSRSPPGVGPEEEEGEGYEEPDSEEDSEFYENDSNLGQDQLSQDGSGYENPEDEPLGPEDEDSFSNAESYENEDEELTQPVARTMDFLSPHGSAWDPSREATSLGSQSYEDMRGILYAAPQLRSIRGQPGPNHEEDADSYENMDNPDGPDPAWGGGGRMGTWSTR
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency, common variable, 3 (CVID3) [MIM:613493]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269|PubMed:16672701}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes (PubMed:29523808). Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (PubMed:1373518, PubMed:16672701, PubMed:2463100). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores (PubMed:12387743, PubMed:16672701, PubMed:9317126, PubMed:9382888). Is not required for early steps during B cell differentiation in the blood marrow (PubMed:9317126). Required for normal differentiation of B-1 cells (By similarity). Required for normal B cell differentiation and proliferation in response to antigen challenges (PubMed:1373518, PubMed:2463100). Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge (PubMed:12387743, PubMed:16672701, PubMed:9317126). {ECO:0000250|UniProtKB:P25918, ECO:0000269|PubMed:12387743, ECO:0000269|PubMed:1373518, ECO:0000269|PubMed:16672701, ECO:0000269|PubMed:2463100, ECO:0000269|PubMed:29523808, ECO:0000269|PubMed:9317126, ECO:0000269|PubMed:9382888}.
uniprot
proteins
mass_dalton
61128
uniprot
proteins
mutagenesis
MUTAGEN 309..556; /note="Missing: Abolishes the ability to activate signaling pathways that mediate mobilization of cytoplasmic Ca(2+). Abolishes the ability to restore normal B cell functions and responses to antigenic stimuli."; /evidence="ECO:0000269|PubMed:9317126"; MUTAGEN 348; /note="Y->F: No effect on the ability to complement impaired B cell development and functions; when associated with F-378."; /evidence="ECO:0000269|PubMed:12387743"; MUTAGEN 378; /note="Y->F: No effect on the ability to complement impaired B cell development and functions; when associated with F-348."; /evidence="ECO:0000269|PubMed:12387743"; MUTAGEN 409; /note="Y->F: No effect on the ability to complement impaired B cell development and functions; when associated with F-439."; /evidence="ECO:0000269|PubMed:12387743"; MUTAGEN 421; /note="Y->F: No effect on the ability to complement impaired B cell development and functions; when associated with F-461."; /evidence="ECO:0000269|PubMed:12387743"; MUTAGEN 439; /note="Y->F: No effect on the ability to complement impaired B cell development and functions; when associated with F-409."; /evidence="ECO:0000269|PubMed:12387743"; MUTAGEN 461; /note="Y->F: No effect on the ability to complement impaired B cell development and functions; when associated with F-421."; /evidence="ECO:0000269|PubMed:12387743"; MUTAGEN 500; /note="Y->F: Strongly reduced tyrosine phosphorylation; when associated with F-531. Abolishes activation of signaling pathways that mediate mobilization of cytoplasmic Ca(2+); when associated with F-531. Abolishes the ability to complement impaired B cell development and functions; when associated with F-531."; /evidence="ECO:0000269|PubMed:12387743, ECO:0000269|PubMed:7684160, ECO:0000269|PubMed:9382888"; MUTAGEN 531; /note="Y->F: Strongly reduced tyrosine phosphorylation; when associated with F-500. Abolishes activation of signaling pathways that mediate mobilization of cytoplasmic Ca(2+); when associated with F-500. Abolishes the ability to complement impaired B cell development and functions; when associated with F-500."; /evidence="ECO:0000269|PubMed:12387743, ECO:0000269|PubMed:7684160, ECO:0000269|PubMed:9382888
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine following B-cell activation (PubMed:10706702, PubMed:12387743, PubMed:7684160, PubMed:7687539). Phosphorylated on tyrosine residues by LYN (PubMed:7687428). Tyrosine residues are phosphorylated sequentially after activation of the B cell receptor. Phosphorylation of Tyr-531 is extremely rapid, followed by phosphorylation at Tyr-409. In contrast, phosphorylation of Tyr-500 appears more slowly and is more transient, returning rapidly to basal levels (By similarity). {ECO:0000250|UniProtKB:P25918, ECO:0000269|PubMed:10706702, ECO:0000269|PubMed:12387743, ECO:0000269|PubMed:7684160, ECO:0000269|PubMed:7687428, ECO:0000269|PubMed:7687539}.
uniprot
proteins
pubmed
10706702
uniprot
proteins
pubmed
12215898
uniprot
proteins
pubmed
12387743
uniprot
proteins
pubmed
1370948
uniprot
proteins
pubmed
1373518
uniprot
proteins
pubmed
1375324
uniprot
proteins
pubmed
1383329
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
16449649
uniprot
proteins
pubmed
16672701
uniprot
proteins
pubmed
1702139
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
2459292
uniprot
proteins
pubmed
2463100
uniprot
proteins
pubmed
2472450
uniprot
proteins
pubmed
29490423
uniprot
proteins
pubmed
29523808
uniprot
proteins
pubmed
7684160
uniprot
proteins
pubmed
7687428
uniprot
proteins
pubmed
7687539
uniprot
proteins
pubmed
9317126
uniprot
proteins
pubmed
9382888
uniprot
proteins
sequence_length
556
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1373518, ECO:0000269|PubMed:1383329, ECO:0000269|PubMed:16672701, ECO:0000269|PubMed:1702139, ECO:0000269|PubMed:2463100, ECO:0000269|PubMed:9317126, ECO:0000269|PubMed:9382888}; Single-pass type I membrane protein {ECO:0000305}. Membrane raft {ECO:0000250|UniProtKB:P25918}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P25918}.
uniprot
proteins
transmembrane_region
TRANSMEM 292..313; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins