S100A3
entrez
6274
canonical
uniprot
P33764
canonical
ensembl
ENSG00000188015
resolver
ensp
ENSP00000357701
resolver
ensp
ENSP00000357702
resolver
ensp
ENSP00000543935
resolver
ensp
ENSP00000543936
resolver
ensp
ENSP00000599855
resolver
ensp
ENSP00000639339
resolver
enst
ENST00000368712
resolver
enst
ENST00000368713
resolver
enst
ENST00000873876
resolver
enst
ENST00000873877
resolver
enst
ENST00000929796
resolver
enst
ENST00000969280
resolver
genesymbol
S100A3
resolver
genesymbol_syn
S100E
resolver
hgnc
HGNC:10493
resolver
uniprot
D3DV51
resolver
uniprot
Q6FGE4
resolver
uniprot_entry
S10A3_HUMAN
resolver
uniprot_sec
D3DV51
resolver
uniprot_sec
Q6FGE4
resolver
amino_acid_sequence
MARPLEQAVAAIVCTFQEYAGRCGDKYKLCQAELKELLQKELATWTPTEFRECDYNKFMSVLDTNKDCEVDFVEYVRSLACLCLYCHEYFKDCPSEPPCSQ
uniprot
proteins
function
FUNCTION: Binds both calcium and zinc. May be involved in calcium-dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation. {ECO:0000269|PubMed:18083705}.
uniprot
proteins
mass_dalton
11713
uniprot
proteins
mutagenesis
MUTAGEN 30; /note="C->A: Abolishes calcium binding; when associated with Ala-68."; /evidence="ECO:0000269|PubMed:21377473"; MUTAGEN 68; /note="C->A: Abolishes calcium binding; when associated with Ala-30."; /evidence="ECO:0000269|PubMed:21377473"; MUTAGEN 81; /note="C->A: Increases affinity for calcium; when associated with Ala-99."; /evidence="ECO:0000269|PubMed:21377473"; MUTAGEN 99; /note="C->A: Increases affinity for calcium; when associated with Ala-81."; /evidence="ECO:0000269|PubMed:21377473
uniprot
proteins
post_translational_modification
PTM: More than half of the arginine residues undergo citrullination by PAD1 and PAD2. Arg-51 is specifically citrullinated by PAD3 and promotes tetramerization. {ECO:0000269|PubMed:18083705}.
uniprot
proteins
protein_family
S-100 family
uniprot
proteins
pubmed
12136135
uniprot
proteins
pubmed
12470658
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18083705
uniprot
proteins
pubmed
21377473
uniprot
proteins
pubmed
8341667
uniprot
proteins
pubmed
9920417
uniprot
proteins
sequence_length
101
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18083705}.
uniprot
proteins