PLEKHF2
entrez
79666
canonical
uniprot
Q9H8W4
canonical
ensembl
ENSG00000175895
resolver
ensp
ENSP00000322373
resolver
ensp
ENSP00000427792
resolver
ensp
ENSP00000515158
resolver
ensp
ENSP00000515159
resolver
ensp
ENSP00000515160
resolver
ensp
ENSP00000515161
resolver
ensp
ENSP00000578216
resolver
ensp
ENSP00000615971
resolver
enst
ENST00000315367
resolver
enst
ENST00000519516
resolver
enst
ENST00000700745
resolver
enst
ENST00000700746
resolver
enst
ENST00000700748
resolver
enst
ENST00000700749
resolver
enst
ENST00000908157
resolver
enst
ENST00000945912
resolver
genesymbol
PLEKHF2
resolver
genesymbol_syn
ZFYVE18
resolver
hgnc
HGNC:20757
resolver
uniprot_entry
PKHF2_HUMAN
resolver
amino_acid_sequence
MVDRLANSEANTRRISIVENCFGAAGQPLTIPGRVLIGEGVLTKLCRKKPKARQFFLFNDILVYGNIVIQKKKYNKQHIIPLENVTIDSIKDEGDLRNGWLIKTPTKSFAVYAATATEKSEWMNHINKCVTDLLSKSGKTPSNEHAAVWVPDSEATVCMRCQKAKFTPVNRRHHCRKCGFVVCGPCSEKRFLLPSQSSKPVRICDFCYDLLSAGDMATCQPARSDSYSQSLKSPLNDMSDDDDDDDSSD
uniprot
proteins
function
FUNCTION: May play a role in early endosome fusion upstream of RAB5, hence regulating receptor trafficking and fluid-phase transport. Enhances cellular sensitivity to TNF-induced apoptosis (PubMed:18288467). {ECO:0000269|PubMed:18288467, ECO:0000269|PubMed:19995552, ECO:0000269|PubMed:22816767}.
uniprot
proteins
mass_dalton
27798
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18288467
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19995552
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22816767
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
249
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:19995552, ECO:0000269|PubMed:22816767}; Peripheral membrane protein {ECO:0000305|PubMed:19995552, ECO:0000305|PubMed:22816767}. Endoplasmic reticulum {ECO:0000269|PubMed:18288467}. Note=Colocalizes with EEA1 and RAB5 at endosomal membrane fusion hot spots (PubMed:19995552). May translocate to the endoplasmic reticulum in the early phase of apoptosis (PubMed:18288467). {ECO:0000269|PubMed:18288467, ECO:0000269|PubMed:19995552}.
uniprot
proteins