Rbck1
entrez
24105
canonical
uniprot
Q9WUB0
canonical
ensembl
ENSMUSG00000027466
resolver
ensp
ENSMUSP00000028964
resolver
ensp
ENSMUSP00000105473
resolver
ensp
ENSMUSP00000312162
resolver
ensp
ENSMUSP00000312164
resolver
ensp
ENSMUSP00000312166
resolver
ensp
ENSMUSP00000312180
resolver
ensp
ENSMUSP00000312185
resolver
ensp
ENSMUSP00000312189
resolver
ensp
ENSMUSP00000312191
resolver
ensp
ENSMUSP00000312199
resolver
ensp
ENSMUSP00000312208
resolver
ensp
ENSMUSP00000346203
resolver
enst
ENSMUST00000028964
resolver
enst
ENSMUST00000109847
resolver
genesymbol
Rbck1
resolver
genesymbol_syn
Rbck
resolver
genesymbol_syn
Ubce7ip3
resolver
genesymbol_syn
Uip28
resolver
uniprot
A2ANR4
resolver
uniprot
Q3TM86
resolver
uniprot
Q8C2I0
resolver
uniprot_entry
HOIL1_MOUSE
resolver
uniprot_sec
A2ANR4
resolver
uniprot_sec
Q3TM86
resolver
uniprot_sec
Q8C2I0
resolver
amino_acid_sequence
MDEKTKKAEEMALSLARAVAGGDEQAAIKYATWLAEQRVPLRVQVKPEVSPTQDIRLCVSVEDAYMHTVTIWLTVRPDMTVASLKDMVFLDYGFPPSLQQWVVGQRLARDQETLHSHGIRRNGDGAYLYLLSARNTSLNPQELQRQRQLRMLEDLGFKDLTLQSRGPLEPVLPKPRTNQEPGQPDAAPESPPVGWQCPGCTFINKPTRPGCEMCCRARPETYQIPASYQPDEEERARLAGEEEALRQYQQRKQQQQEGNYLQHVQLEQRSLVLNTEPTECPVCYSVLAPGEAVVLRECLHTFCRECLQGTIRNSQEAEVACPFIDSTYSCPGKLLEREIRALLSPEDYQRFLDLGVSIAENRSTLSYHCKTPDCRGWCFFEDDVNEFTCPVCTRVNCLLCKAIHEHMNCREYQDDLALRAQNDVAARQTTEMLKVMLQQGEAMHCPQCRIVVQKKDGCDWIRCTVCHTEICWVTKGPRWGPGGPGDTSGGCRCRVNGIPCHPSCQNCH
uniprot
proteins
ec_number
2.3.2.31
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2L3/UBCM4, and then transfers it to substrates. Functions as an E3 ligase for oxidized IREB2 and both heme and oxygen are necessary for IREB2 ubiquitination. Promotes ubiquitination of TAB2 and IRF3 and their degradation by the proteasome. Component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation. LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways. Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation. LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex. The LUBAC complex is also involved in innate immunity by conjugating linear polyubiquitin chains at the surface of bacteria invading the cytosol to form the ubiquitin coat surrounding bacteria. LUBAC is not able to initiate formation of the bacterial ubiquitin coat, and can only promote formation of linear polyubiquitins on pre-existing ubiquitin. The bacterial ubiquitin coat acts as an 'eat-me' signal for xenophagy and promotes NF-kappa-B activation. Together with OTULIN, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types. {ECO:0000250|UniProtKB:Q9BYM8}.
uniprot
proteins
mass_dalton
57534
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9BYM8}.
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated. Auto-ubiquitination leads to degradation by the proteasome (By similarity). {ECO:0000250|UniProtKB:Q62921}.; PTM: Phosphorylated. In vitro, phosphorylation inhibits auto-ubiquitination activity (By similarity). {ECO:0000250|UniProtKB:Q62921}.
uniprot
proteins
protein_family
RBR family
uniprot
proteins
pubmed
10431818
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
19136968
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20956555
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22139374
uniprot
proteins
sequence_length
508
uniprot
proteins