Azin2
entrez
242669
canonical
uniprot
Q8BVM4
canonical
ensembl
ENSMUSG00000028789
resolver
ensp
ENSMUSP00000030581
resolver
ensp
ENSMUSP00000101683
resolver
ensp
ENSMUSP00000114086
resolver
ensp
ENSMUSP00000225353
resolver
enst
ENSMUST00000030581
resolver
enst
ENSMUST00000106068
resolver
enst
ENSMUST00000119354
resolver
genesymbol
Azin2
resolver
genesymbol_syn
Adc
resolver
genesymbol_syn
Odcp
resolver
uniprot
A2A823
resolver
uniprot
A8Y5E7
resolver
uniprot
B2RSR5
resolver
uniprot
Q6P078
resolver
uniprot_entry
A8Y5E7_MOUSE
resolver
uniprot_entry
AZIN2_MOUSE
resolver
uniprot_entry
B2RSR5_MOUSE
resolver
uniprot_entry
Q6P078_MOUSE
resolver
uniprot_sec
A2A823
resolver
amino_acid_sequence
MAGYLSESDFVMVEEGFSTRDLLEELTLGASQATSGKVAAFFVADLGAVVRKHFCFLKHLPRVRPFYAVGCNSSLGVLKVLAELGLGFSCANKAEMELVQHIGVPASKIICANPCKQVAQIKYAAKHGVRLLSFDNEVELAKVVKSHPSAKMVLCIATQDSHSLNHLSLRFGASLKSCRHLLENAKKSHVEVVGVSFHIGSGCPDPQAYAQSIADARLVFQMGEELGHTMNILDLGGGFPGLEGAKVRFEEMASVINSALDLYFPEGCGVDILAELGRYYVTSAFTVAVSIVAKREVLDQASREEQTGAAPKSIVYYLDEGVYGVFNSVLFDNTCPTPALQKKPSADQPLYSSSLWGPAVEGCDCVAEGLWLPQLQVGDWLVFDNMGAYTVDTKSLLGGTQARRVTYAMSRLAWEALRGQLLPAEEDQDAEGVCKPLSCGWEITDTLCVGPVFTPASIM
uniprot
proteins
function
FUNCTION: Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding (PubMed:18062773, PubMed:18508777, PubMed:18973822). Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production (PubMed:16916800, PubMed:24967154). Participates in the morphological integrity of the trans-Golgi network (TGN) and functions as a regulator of intracellular secretory vesicle trafficking (By similarity). {ECO:0000250|UniProtKB:Q96A70, ECO:0000269|PubMed:16916800, ECO:0000269|PubMed:18062773, ECO:0000269|PubMed:18508777, ECO:0000269|PubMed:18973822, ECO:0000269|PubMed:24967154}.
uniprot
proteins
mass_dalton
49503
uniprot
proteins
mutagenesis
MUTAGEN 116; /note="K->A: Does not inhibit interaction with OAZ1. Reduces interaction with OAZ1; when associated with A-142."; /evidence="ECO:0000269|PubMed:24967154"; MUTAGEN 124; /note="A->S: Does not inhibit interaction with OAZ1."; /evidence="ECO:0000269|PubMed:24967154"; MUTAGEN 139; /note="E->A: Strongly reduces interaction with OAZ1 and unable to abrogate both the inhibitory effect of OAZ1 on ornithine decarboxylase (ODC) activity and polyamine uptake; when associated with A-140 and A-142."; /evidence="ECO:0000269|PubMed:24967154"; MUTAGEN 140; /note="L->A: Strongly reduces interaction with OAZ1 and unable to abrogate both the inhibitory effect of OAZ1 on ornithine decarboxylase (ODC) activity and polyamine uptake; when associated with A-139 and A-142."; /evidence="ECO:0000269|PubMed:24967154"; MUTAGEN 142; /note="K->A: Does not inhibit interaction with OAZ1. Reduces interaction with OAZ1; when associated with A-116. Strongly reduces interaction with OAZ1 and unable to abrogate the inhibitory effect of OAZ1 on ornithine decarboxylase (ODC) activity and polyamine uptake; when associated with A-139 and A-140."; /evidence="ECO:0000269|PubMed:24967154
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, leading to its proteasomal degradation; a process that is reduced in presence of antizymes. May also be degraded through the lysosomal degradative pathway in a proteasomal-independent manner. {ECO:0000269|PubMed:18062773}.
uniprot
proteins
protein_family
ODC antizyme inhibitor subfamily
uniprot
proteins
protein_family
Orn/Lys/Arg decarboxylase class-II family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16916800
uniprot
proteins
pubmed
18062773
uniprot
proteins
pubmed
18508777
uniprot
proteins
pubmed
18973822
uniprot
proteins
pubmed
19449338
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19956990
uniprot
proteins
pubmed
22562773
uniprot
proteins
pubmed
23874910
uniprot
proteins
pubmed
24967154
uniprot
proteins
sequence_length
459
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cytoplasm, perinuclear region {ECO:0000250}. Membrane. Cytoplasmic vesicle {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment. Golgi apparatus, cis-Golgi network. Golgi apparatus, trans-Golgi network {ECO:0000250}. Cytoplasmic granule. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Perikaryon {ECO:0000250}. Note=Detected as vesicle-like pattern in neurite outgrowths. Localizes to the vesicular compartments of the secretory pathway, predominantly in the trans-Golgi network (TGN). Localizes with vesicle-associated membrane protein VAMP8 in the vicinity of the plasma membrane within serotonin-containing secretory granules (By similarity). Colocalizes with KDEL receptors in ER-Golgi intermediate compartment (ERGIC). Translocates from the ERGIC structure to the cytoplasm in a antizyme-dependent manner. Localizes with vesicle-associated membrane protein VAMP8 in the vicinity of the plasma membrane within serotonin-containing secretory granules. {ECO:0000250}.
uniprot
proteins