Kdm1a
entrez
99982
canonical
uniprot
Q6ZQ88
canonical
ensembl
ENSMUSG00000036940
resolver
ensp
ENSMUSP00000101473
resolver
ensp
ENSMUSP00000111977
resolver
ensp
ENSMUSP00000274416
resolver
enst
ENSMUST00000116273
resolver
genesymbol
Kdm1a
resolver
genesymbol_syn
Aof2
resolver
genesymbol_syn
Kiaa0601
resolver
genesymbol_syn
Lsd1
resolver
uniprot
A3KG93
resolver
uniprot
A3KG94
resolver
uniprot
F6Z4I3
resolver
uniprot
Q6PB53
resolver
uniprot
Q8VEA1
resolver
uniprot_entry
KDM1A_MOUSE
resolver
uniprot_sec
A3KG93
resolver
uniprot_sec
A3KG94
resolver
uniprot_sec
F6Z4I3
resolver
uniprot_sec
Q6PB53
resolver
uniprot_sec
Q8VEA1
resolver
activity_regulation
ACTIVITY REGULATION: The N-terminal sequences of INSM1 and SNAI1 compete with histone H3 for the same binding site and thereby inhibit histone demethylation (in vitro). {ECO:0000250|UniProtKB:O60341}.
uniprot
proteins
amino_acid_sequence
MLSGKKAAAAAAAAAAAAAAGTEAGSGAAGGAENGSEVAAPPAGLTGPTDMATGAAGERTPRKKEPPRASPPGGLAEPPGSAGPQAGPTAGPGSATPMETGIAETPEGRRTSRRKRAKVEYREMDESLANLSEDEYYSEEERNAKAEKEKKLPPPPPQAPPEEENESEPEEPSGVEGAAFQSRLPHDRMTSQEAACFPDIISGPQQTQKVFLFIRNRTLQLWLDNPKIQLTFEATLQQLEAPYNSDTVLVHRVHSYLERHGLINFGIYKRIKPLPIKKTGKVIIIGSGVSGLAAARQLQSFGMDVTLLEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNPMAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKDEMVEQEFNRLLEATSYLSHQLDFNVLNNKPVSLGQALEVVIQLQEKHVKDEQIEHWKKIVKTQEELKELLNKMVNLKEKIKELHQQYKEASEVKPPRDITAEFLVKSKHRDLTALCKEYDELAETQGKLEEKLQELEANPPSDVYLSSRDRQILDWHFANLEFANATPLSTLSLKHWDQDDDFEFTGSHLTVRNGYSCVPVALAEGLDIKLNTAVRQVRYTASGCEVIAVNTRSTSQTFIYKCDAVLCTLPLGVLKQQPPAVQFVPPLPEWKTSAVQRMGFGNLNKVVLCFDRVFWDPSVNLFGHVGSTTASRGELFLFWNLYKAPILLALVAGEAAGIMENISDDVIVGRCLAILKGIFGSSAVPQPKETVVSRWRADPWARGSYSYVAAGSSGNDYDLMAQPITPGPSIPGAPQPIPRLFFAGEHTIRNYPATVHGALLSGLREAGRIADQFLGAMYTLPRQATPGVPAQQSPSM
uniprot
proteins
ec_number
1.14.11.-
uniprot
proteins
ec_number
1.14.11.65
uniprot
proteins
ec_number
1.14.99.66
uniprot
proteins
function
FUNCTION: Histone demethylase that can demethylate both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context (PubMed:19098913). Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me. May play a role in the repression of neuronal genes. Alone, it is unable to demethylate H3K4me on nucleosomes and requires the presence of RCOR1/CoREST to achieve such activity. Also acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and mediating demethylation of H3K9me, a specific tag for epigenetic transcriptional repression. The presence of PRKCB in ANDR-containing complexes, which mediates phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag that prevents demethylation H3K4me, prevents H3K4me demethylase activity of KDM1A. Demethylates di-methylated 'Lys-370' of p53/TP53 which prevents interaction of p53/TP53 with TP53BP1 and represses p53/TP53-mediated transcriptional activation (By similarity). Demethylates and stabilizes the DNA methylase DNMT1 (By similarity). Demethylates methylated 'Lys-44' and methylated 'Lys-119' of SOX2 (By similarity). Required for gastrulation during embryogenesis. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (PubMed:17707228). Facilitates epithelial-to-mesenchymal transition by acting as an effector of SNAI1-mediated transcription repression of epithelial markers E-cadherin/CDH1, CDN7 and KRT8. Required for the maintenance of the silenced state of the SNAI1 target genes E-cadherin/CDH1 and CDN7. Required for the repression of GIPR expression (By similarity). {ECO:0000250|UniProtKB:O60341, ECO:0000269|PubMed:17707228, ECO:0000269|PubMed:19098913}.; FUNCTION: [Isoform 2]: Neuron-specific histone demethylase that demethylates mono- and dimethylated 'Lys-20' of histone H4 (H4K20me1 and H4K20me2), a chromatin repressive mark (By similarity). This demethylation is crucial for the initiation and elongation of neuronal activity-regulated genes, required for spatial learning and memory (PubMed:26214369, PubMed:26976584). Mediates H3K9me2 demethylation through cooperation with the supervillin protein (SVIL), and this H3K9 demethylase activity is essential for regulating gene expression during neuronal differentiation (By similarity). {ECO:0000250|UniProtKB:O60341, ECO:0000269|PubMed:26214369, ECO:0000269|PubMed:26976584}.; FUNCTION: [Isoform 4]: Neuron-specific histone demethylase that demethylates mono- and dimethylated 'Lys-20' of histone H4 (H4K20me1 and H4K20me2), a chromatin repressive mark (By similarity). This demethylation is crucial for the initiation and elongation of neuronal activity-regulated genes, required for spatial learning and memory (PubMed:26214369). Mediates H3K9me2 demethylation through cooperation with the supervillin protein (SVIL), and this H3K9 demethylase activity is essential for regulating gene expression during neuronal differentiation (By similarity). {ECO:0000250|UniProtKB:O60341, ECO:0000269|PubMed:26214369}.
uniprot
proteins
mass_dalton
92851
uniprot
proteins
post_translational_modification
PTM: Acetylated by KAT8 in epithelial but not in mesenchymal cells, thereby regulating the epithelial-to-mesenchymal transition (By similarity). Acetylation by KAT8 reduces KDM1A association with nucleosomes, thereby decreasing histone H3 demethylation, leading to transcription activation of target genes (By similarity). {ECO:0000250|UniProtKB:O60341}.; PTM: Polyubiquitinated by JADE2; which leads to its proteasomal degradation (PubMed:25018020). Deubiquitinated by USP38; preventing it from degradation by the 26S proteasome (By similarity). {ECO:0000250|UniProtKB:O60341, ECO:0000269|PubMed:25018020}.
uniprot
proteins
protein_family
Flavin monoamine oxidase family
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16079795
uniprot
proteins
pubmed
17707228
uniprot
proteins
pubmed
19098913
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20164337
uniprot
proteins
pubmed
20713442
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24227653
uniprot
proteins
pubmed
25018020
uniprot
proteins
pubmed
26206133
uniprot
proteins
pubmed
26214369
uniprot
proteins
pubmed
26976584
uniprot
proteins
pubmed
33980486
uniprot
proteins
sequence_length
853
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:33980486}. Chromosome {ECO:0000250|UniProtKB:O60341}. Note=Associates with chromatin. {ECO:0000250|UniProtKB:O60341}.
uniprot
proteins