Nkx2-5
entrez
114109
canonical
uniprot
O35767
canonical
ensembl
ENSRNOG00000020747
resolver
ensp
ENSRNOP00000028155
resolver
enst
ENSRNOT00000028155
resolver
genesymbol
Nkx2-5
resolver
genesymbol_syn
Csx
resolver
genesymbol_syn
Nkx-2.5
resolver
genesymbol_syn
Nkx2e
resolver
uniprot
G3V8T2
resolver
uniprot_entry
G3V8T2_RAT
resolver
uniprot_entry
NKX25_RAT
resolver
amino_acid_sequence
MFPSPALTHTPFSVKDILNLEQQQRSLAAGDLSARLEATLAPASCMLAAFKPDGYSGPEAAAPGLAELRAELGPAPSPPKCSPAFPTAPTFYPRAYGDPDPAKDPRADKKELCALQKAVELDKAETDGAERRRPRRRRKPRVLFSQAQVYELERRFKQQRYLSPAERDQLASVLKLTSTQVKIWFQNRRYKCKRQRQDQTLELLGPPPPPARRIAVPVLVRDGKPCLGDSAAYAPAYGLGLNAYGYNAYPYPGYGGAACSPAYSCAAYPAAPPAAHAPAASANSNFVNFGVGDLNTVQSPGMPQGNSGVSTLHGIRAW
uniprot
proteins
function
FUNCTION: Transcription factor required for the development of the heart and the spleen (By similarity). During heart development, acts as a transcriptional activator of NPPA/ANF in cooperation with GATA4 (By similarity). May cooperate with TBX2 to negatively modulate expression of NPPA/ANF in the atrioventricular canal (By similarity). Binds to the core DNA motif of NPPA promoter. Together with PBX1, required for spleen development through a mechanism that involves CDKN2B repression (By similarity). Positively regulates transcription of genes such as COL3A1 and MMP2, resulting in increased pulmonary endothelial fibrosis in response to hypoxia (By similarity). {ECO:0000250|UniProtKB:P42582, ECO:0000250|UniProtKB:P52952}.
uniprot
proteins
mass_dalton
34336
uniprot
proteins
protein_family
NK-2 homeobox family
uniprot
proteins
sequence_length
318
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P42582}.
uniprot
proteins