POC5
entrez
134359
canonical
uniprot
Q8NA72
canonical
ensembl
ENSG00000152359
resolver
ensp
ENSP00000399481
resolver
ensp
ENSP00000410216
resolver
ensp
ENSP00000426796
resolver
ensp
ENSP00000574715
resolver
ensp
ENSP00000723719
resolver
ensp
ENSP00000779193
resolver
genesymbol
POC5
resolver
genesymbol_syn
C5orf37
resolver
hgnc
HGNC:26658
resolver
uniprot
B4DJG7
resolver
uniprot
Q494X7
resolver
uniprot
Q494X9
resolver
uniprot
Q6P085
resolver
uniprot_entry
POC5_HUMAN
resolver
uniprot_sec
B4DJG7
resolver
uniprot_sec
Q494X7
resolver
uniprot_sec
Q494X9
resolver
uniprot_sec
Q6P085
resolver
amino_acid_sequence
MSSDEEKYSLPVVQNDSSRGSSVSSNLQEEYEELLHYAIVTPNIEPCASQSSHPKGELVPDVRISTIHDILHSQGNNSEVRETAIEVGKGCDFHISSHSKTDESSPVLSPRKPSHPVMDFFSSHLLADSSSPATNSSHTDAHEILVSDFLVSDENLQKMENVLDLWSSGLKTNIISELSKWRLNFIDWHRMEMRKEKEKHAAHLKQLCNQINELKELQKTFEISIGRKDEVISSLSHAIGKQKEKIELMRTFFHWRIGHVRARQDVYEGKLADQYYQRTLLKKVWKVWRSVVQKQWKDVVERACQARAEEVCIQISNDYEAKVAMLSGALENAKAEIQRMQHEKEHFEDSMKKAFMRGVCALNLEAMTIFQNRNDAGIDSTNNKKEEYGPGVQGKEHSAHLDPSAPPMPLPVTSPLLPSPPAAVGGASATAVPSAASMTSTRAASASSVHVPVSALGAGSAATAASEEMYVPRVVTSAQQKAGRTITARITGRCDFASKNRISSSLAIMGVSPPMSSVVVEKHHPVTVQTIPQATAAKYPRTIHPESSTSASRSLGTRSAHTQSLTSVHSIKVVD
uniprot
proteins
function
FUNCTION: Essential for the assembly of the distal half of centrioles, required for centriole elongation (PubMed:19349582, PubMed:32946374). Acts as a negative regulator of centriole elongation (PubMed:37934472). {ECO:0000269|PubMed:19349582, ECO:0000269|PubMed:32946374, ECO:0000269|PubMed:37934472}.
uniprot
proteins
mass_dalton
63351
uniprot
proteins
post_translational_modification
PTM: Hyperphosphorylated during recruitment to procentrioles in G2/M phase. {ECO:0000269|PubMed:19349582}.
uniprot
proteins
protein_family
POC5 family
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19349582
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
32110738
uniprot
proteins
pubmed
32946374
uniprot
proteins
pubmed
37934472
uniprot
proteins
sequence_length
575
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:37934472}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:19349582, ECO:0000269|PubMed:32110738, ECO:0000269|PubMed:32946374, ECO:0000269|PubMed:37934472}. Note=Localized to the distal portion of centrioles. Localizes to the inner scaffold in the central region of centrioles. {ECO:0000269|PubMed:32110738, ECO:0000269|PubMed:37934472}.
uniprot
proteins