Socs2
entrez
216233
canonical
uniprot
O35717
canonical
ensembl
ENSMUSG00000020027
resolver
ensp
ENSMUSP00000020215
resolver
ensp
ENSMUSP00000113378
resolver
ensp
ENSMUSP00000129331
resolver
ensp
ENSMUSP00000131875
resolver
ensp
ENSMUSP00000215923
resolver
ensp
ENSMUSP00000215925
resolver
ensp
ENSMUSP00000215926
resolver
ensp
ENSMUSP00000215927
resolver
ensp
ENSMUSP00000215929
resolver
ensp
ENSMUSP00000215930
resolver
ensp
ENSMUSP00000215933
resolver
ensp
ENSMUSP00000345587
resolver
ensp
ENSMUSP00000353565
resolver
enst
ENSMUST00000020215
resolver
enst
ENSMUST00000119917
resolver
enst
ENSMUST00000170690
resolver
enst
ENSMUST00000172070
resolver
genesymbol
Socs2
resolver
uniprot
Q548Q7
resolver
uniprot_entry
Q548Q7_MOUSE
resolver
uniprot_entry
SOCS2_MOUSE
resolver
amino_acid_sequence
MTLRCLEPSGNGADRTRSQWGTAGLPEEQSPEAARLAKALRELSQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTSAPTLQHFCRLAINKCTGTIWGLPLPTRLKDYLEEYKFQV
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as EPOR and GHR (By similarity). Specifically recognizes and binds phosphorylated proteins via its SH2 domain, promoting their ubiquitination (By similarity). The ECS(SOCS2) complex acts as a key regulator of growth hormone receptor (GHR) levels by mediating ubiquitination and degradation of GHR, following GHR phosphorylation by JAK2 (PubMed:10890450, PubMed:15690087). The ECS(SOCS2) also catalyzes ubiquitination and degradation of JAK2-phosphorylated EPOR (By similarity). {ECO:0000250|UniProtKB:O14508, ECO:0000269|PubMed:10890450, ECO:0000269|PubMed:15690087}.
uniprot
proteins
mass_dalton
22434
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:O14508}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; mediated by AREL1 and leading to its subsequent proteasomal degradation (PubMed:31578312). Ubiquitination is dependent on phosphorylation at Ser-52, by PKC and is stimulated by LPS (PubMed:31578312). {ECO:0000269|PubMed:31578312}.; PTM: Phosphorylation at Ser-52 by PKC facilitates its ubiquitination and proteasomal degradation. {ECO:0000269|PubMed:31578312}.
uniprot
proteins
pubmed
10867663
uniprot
proteins
pubmed
10890450
uniprot
proteins
pubmed
12040024
uniprot
proteins
pubmed
15690087
uniprot
proteins
pubmed
31578312
uniprot
proteins
pubmed
9202125
uniprot
proteins
sequence_length
198
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O14508}.
uniprot
proteins