Pafah1b3
entrez
114113
canonical
uniprot
O35263
canonical
ensembl
ENSRNOG00000020481
resolver
ensembl
ENSRNOG00055033531
resolver
ensembl
ENSRNOG00060030747
resolver
ensembl
ENSRNOG00065001520
resolver
ensembl
ENSRNOG00065032241
resolver
ensp
ENSRNOP00000027774
resolver
ensp
ENSRNOP00055047796
resolver
ensp
ENSRNOP00060044412
resolver
ensp
ENSRNOP00065001435
resolver
ensp
ENSRNOP00065045676
resolver
enst
ENSRNOT00000027774
resolver
enst
ENSRNOT00055057956
resolver
enst
ENSRNOT00060053458
resolver
enst
ENSRNOT00065002034
resolver
enst
ENSRNOT00065055510
resolver
genesymbol
Pafah1b3
resolver
genesymbol_syn
Pafahg
resolver
uniprot_entry
PA1B3_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Beta subunit (PAFAH1B1) inhibits the acetylhydrolase activity of the alpha1/alpha1 catalytic homodimer. {ECO:0000250|UniProtKB:Q29460}.
uniprot
proteins
amino_acid_sequence
MSGEGENPASKPTPVQDVQGDGRWMSLHHRFVADSKDKEPEVVFIGDSLVQLMHQCEIWRELFSPLHALNFGIGGDSTQHVLWRLENGELEHIRPKIVVVWVGTNNHSHTAEQVTGGIKAIVQLVNKLQPQARVVVLGLLPRGQHPNPLREKNRQVNELVRAALAGYPRAHFLDADPGFVHSDGTISHHDMYDYLHLSRLGYTPVCRALHSLLLRLLAQDQGQGIPLPETAP
uniprot
proteins
ec_number
3.1.1.47
uniprot
proteins
function
FUNCTION: Alpha1 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF (PubMed:9660828). The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. Both alpha1/alpha1 homodimer (PAFAH1B3/PAFAH1B3 homodimer) and alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B2 heterodimer) hydrolyze 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA) more efficiently than PAF, but they have little hydrolytic activity towards 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE). Plays an important role during the development of brain (By similarity). {ECO:0000250|UniProtKB:Q29460, ECO:0000269|PubMed:9660828}.
uniprot
proteins
mass_dalton
25863
uniprot
proteins
protein_family
'GDSL' lipolytic enzyme family
uniprot
proteins
protein_family
Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily
uniprot
proteins
pubmed
9459487
uniprot
proteins
pubmed
9660828
uniprot
proteins
sequence_length
232
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins