Eif1a
entrez
13664
canonical
uniprot
Q60872
canonical
ensembl
ENSMUSG00000057561
resolver
ensp
ENSMUSP00000077223
resolver
ensp
ENSMUSP00000157513
resolver
ensp
ENSMUSP00000157583
resolver
ensp
ENSMUSP00000158417
resolver
ensp
ENSMUSP00000158565
resolver
enst
ENSMUST00000078079
resolver
enst
ENSMUST00000235455
resolver
enst
ENSMUST00000235973
resolver
enst
ENSMUST00000237478
resolver
enst
ENSMUST00000238168
resolver
genesymbol
Eif1a
resolver
uniprot
A0A494BB95
resolver
uniprot
O88847
resolver
uniprot
Q4FJR7
resolver
uniprot
Q8R2M4
resolver
uniprot
Q9CX76
resolver
uniprot
Q9DB61
resolver
uniprot_entry
A0A494BB95_MOUSE
resolver
uniprot_entry
IF1A_MOUSE
resolver
uniprot_entry
Q4FJR7_MOUSE
resolver
uniprot_sec
O88847
resolver
uniprot_sec
Q8R2M4
resolver
uniprot_sec
Q9CX76
resolver
uniprot_sec
Q9DB61
resolver
amino_acid_sequence
MPKNKGKGGKNRRRGKNENESEKRELVFKEDGQEYAQVIKMLGNGRLEAMCFDGVRRLCHIRGKLRKKVWINTSDIILIGLRDYQDNKADVILKYNADEARSLKAYGELPEHAKINETDTFGPGDDDEIQFDDIGDDDEDIDDI
uniprot
proteins
function
FUNCTION: Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. This protein enhances formation of the cap-proximal complex. Together with EIF1, facilitates scanning, start codon recognition, promotion of the assembly of 48S complex at the initiation codon (43S PIC becomes 48S PIC after the start codon is reached), and dissociation of aberrant complexes. After start codon location, together with EIF5B orients the initiator methionine-tRNA in a conformation that allows 60S ribosomal subunit joining to form the 80S initiation complex. Is released after 80S initiation complex formation, just after GTP hydrolysis by EIF5B, and before release of EIF5B. Its globular part is located in the A site of the 40S ribosomal subunit. Its interaction with EIF5 during scanning contribute to the maintenance of EIF1 within the open 43S PIC. In contrast to yeast orthologs, does not bind EIF1. {ECO:0000250|UniProtKB:P47813}.
uniprot
proteins
mass_dalton
16502
uniprot
proteins
protein_family
EIF-1A family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
8631492
uniprot
proteins
pubmed
9753744
uniprot
proteins
sequence_length
144
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
uniprot
proteins