Tlr7
entrez
170743
canonical
uniprot
P58681
canonical
ensembl
ENSMUSG00000044583
resolver
ensp
ENSMUSP00000061853
resolver
ensp
ENSMUSP00000107787
resolver
ensp
ENSMUSP00000107789
resolver
enst
ENSMUST00000060719
resolver
enst
ENSMUST00000112161
resolver
enst
ENSMUST00000112164
resolver
genesymbol
Tlr7
resolver
genesymbol_syn
TLR7
resolver
uniprot
Q548J0
resolver
uniprot
Q599W9
resolver
uniprot
Q923I1
resolver
uniprot_entry
Q548J0_MOUSE
resolver
uniprot_entry
Q599W9_MOUSE
resolver
uniprot_entry
TLR7_MOUSE
resolver
uniprot_sec
Q923I1
resolver
activity_regulation
ACTIVITY REGULATION: Activated by guanosine analogs including deoxyguanosine, 7-thia-8-oxoguanosine or 7-deazaguanosine in a RNA-independent manner. {ECO:0000250|UniProtKB:Q9NYK1}.
uniprot
proteins
amino_acid_sequence
MVFSMWTRKRQILIFLNMLLVSRVFGFRWFPKTLPCEVKVNIPEAHVIVDCTDKHLTEIPEGIPTNTTNLTLTINHIPSISPDSFRRLNHLEEIDLRCNCVPVLLGSKANVCTKRLQIRPGSFSGLSDLKALYLDGNQLLEIPQDLPSSLHLLSLEANNIFSITKENLTELVNIETLYLGQNCYYRNPCNVSYSIEKDAFLVMRNLKVLSLKDNNVTAVPTTLPPNLLELYLYNNIIKKIQENDFNNLNELQVLDLSGNCPRCYNVPYPCTPCENNSPLQIHDNAFNSLTELKVLRLHSNSLQHVPPTWFKNMRNLQELDLSQNYLAREIEEAKFLHFLPNLVELDFSFNYELQVYHASITLPHSLSSLENLKILRVKGYVFKELKNSSLSVLHKLPRLEVLDLGTNFIKIADLNIFKHFENLKLIDLSVNKISPSEESREVGFCPNAQTSVDRHGPQVLEALHYFRYDEYARSCRFKNKEPPSFLPLNADCHIYGQTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNTIGQTLNGSELWPLRELRYLDFSNNRLDLLYSTAFEELQSLEVLDLSSNSHYFQAEGITHMLNFTKKLRLLDKLMMNDNDISTSASRTMESDSLRILEFRGNHLDVLWRAGDNRYLDFFKNLFNLEVLDISRNSLNSLPPEVFEGMPPNLKNLSLAKNGLKSFFWDRLQLLKHLEILDLSHNQLTKVPERLANCSKSLTTLILKHNQIRQLTKYFLEDALQLRYLDISSNKIQVIQKTSFPENVLNNLEMLVLHHNRFLCNCDAVWFVWWVNHTDVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSVSISSVLFLMVVMTTSHLFFWDMWYIYYFWKAKIKGYQHLQSMESCYDAFIVYDTKNSAVTEWVLQELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTQKYAKTESFKMAFYLSHQRLLDEKVDVIILIFLEKPLQKSKFLQLRKRLCRSSVLEWPANPQAHPYFWQCLKNALTTDNHVAYSQMFKETV
uniprot
proteins
function
FUNCTION: Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs (PubMed:21402738). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively (By similarity) (PubMed:14976261). In plasmacytoid dendritic cells, RNASET2 endonuclease cooperates with PLD3 or PLD4 5'->3' exonucleases to process RNA and release 2',3'-cyclic guanosine monophosphate (2',3'-cGMP) and cytidine-rich RNA fragments that occupy TLR7 ligand-binding pockets and trigger a signaling-competent state. {ECO:0000250|UniProtKB:Q9NYK1, ECO:0000269|PubMed:14976261, ECO:0000269|PubMed:21402738}.
uniprot
proteins
mass_dalton
121837
uniprot
proteins
mutagenesis
MUTAGEN 264; /note="Y->H: In kika; mice develop autoimmunity with splenomegaly, multiple autoantibodies, and increased total and activated B cells, germinal centers, plasma cells and memory CD4+ T cells."; /evidence="ECO:0000269|PubMed:35477763
uniprot
proteins
post_translational_modification
PTM: The first cleavage is performed by asparagine endopeptidase or cathepsin family members. This initial cleavage event is followed by a trimming event that is solely cathepsin mediated and required for optimal receptor signaling. {ECO:0000269|PubMed:21402738}.
uniprot
proteins
protein_family
Toll-like receptor family
uniprot
proteins
pubmed
14976261
uniprot
proteins
pubmed
17452530
uniprot
proteins
pubmed
18305481
uniprot
proteins
pubmed
21402738
uniprot
proteins
pubmed
26095358
uniprot
proteins
pubmed
35477763
uniprot
proteins
sequence_length
1050
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:18305481}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:18305481}; Single-pass type I membrane protein {ECO:0000269|PubMed:18305481}. Lysosome {ECO:0000269|PubMed:18305481}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:18305481}. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist.
uniprot
proteins
transmembrane_region
TRANSMEM 838..858; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins