Slc25a25
entrez
227731
canonical
uniprot
A2ASZ8
canonical
ensembl
ENSMUSG00000026819
resolver
ensp
ENSMUSP00000028160
resolver
ensp
ENSMUSP00000060581
resolver
ensp
ENSMUSP00000108932
resolver
ensp
ENSMUSP00000108933
resolver
ensp
ENSMUSP00000108936
resolver
genesymbol
Slc25a25
resolver
genesymbol_syn
Kiaa1896
resolver
genesymbol_syn
Scamc2
resolver
uniprot
A2ASZ1
resolver
uniprot
A2ASZ5
resolver
uniprot
A2ASZ9
resolver
uniprot
Q6NXM8
resolver
uniprot
Q80T78
resolver
uniprot
Q8BHG0
resolver
uniprot
Q8JZT8
resolver
uniprot
Q8VBT4
resolver
uniprot
Q99KD3
resolver
uniprot_entry
SCMC2_MOUSE
resolver
uniprot_sec
A2ASZ1
resolver
uniprot_sec
A2ASZ5
resolver
uniprot_sec
A2ASZ9
resolver
uniprot_sec
Q6NXM8
resolver
uniprot_sec
Q80T78
resolver
uniprot_sec
Q8BHG0
resolver
uniprot_sec
Q8JZT8
resolver
uniprot_sec
Q8VBT4
resolver
uniprot_sec
Q99KD3
resolver
activity_regulation
ACTIVITY REGULATION: Activated by an increase in cytosolic calcium levels that induces a conformational change of the N-terminal regulatory domain, uncapping the channel and allowing transport. {ECO:0000250|UniProtKB:Q6NUK1}.
uniprot
proteins
amino_acid_sequence
MLCLCLYVPIAGAAQTEFQYFESKGLPAELKSIFKLSVFIPSQEFSTYRQWKQKIVQAGDKDLDGQLDFEEFVHYLQDHEKKLRLVFKSLDKKNDGRIDAQEIMQSLRDLGVKISEQQAEKILKSMDKNGTMTIDWNEWRDYHLLHPVENIPEIILYWKHSTIFDVGENLTVPDEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMCIVGGFTQMIREGGAKSLWRGNGINVLKIAPESAIKFMAYEQMKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALRKTGQYSGMLDCARRILAKEGVAAFYKGYIPNMLGIIPYAGIDLAVYETLKNTWLQRYAVNSADPGVFVLLACGTISSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKQILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITLGVQSR
uniprot
proteins
function
FUNCTION: Electroneutral antiporter that most probably mediates the transport of adenyl nucleotides through the inner mitochondrial membrane (By similarity). Has calcium-dependent ATP-magnesium/inorganic phosphate antiporter activity (PubMed:21296886, PubMed:30080851). Could have a broader specificity for adenyl nucleotides (By similarity). By regulating the mitochondrial matrix adenyl nucleotide pool, could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways (By similarity). Acts downstream of Ca(2+)-permeable cation channel PKD2/TRPP2 and it is likely that PKD2-mediated Ca(2+) signaling activates SLC25A25 antiporter activity (PubMed:30080851). Required for left-right pattern specification (By similarity). {ECO:0000250|UniProtKB:A2CEQ0, ECO:0000250|UniProtKB:Q6NUK1, ECO:0000269|PubMed:21296886, ECO:0000269|PubMed:30080851}.
uniprot
proteins
mass_dalton
52621
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15054102
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21296886
uniprot
proteins
pubmed
30080851
uniprot
proteins
sequence_length
469
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:15054102}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 190..207; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 245..264; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 288..301; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 338..357; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 381..398; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 438..457; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins