REG3G
entrez
130120
canonical
uniprot
Q6UW15
canonical
ensembl
ENSG00000143954
resolver
ensp
ENSP00000272324
resolver
ensp
ENSP00000377475
resolver
ensp
ENSP00000387105
resolver
ensp
ENSP00000540626
resolver
ensp
ENSP00000614307
resolver
ensp
ENSP00000763284
resolver
genesymbol
REG3G
resolver
genesymbol_syn
PAP1B
resolver
hgnc
HGNC:29595
resolver
uniprot
A8K980
resolver
uniprot
D6W5J6
resolver
uniprot
Q3SYE4
resolver
uniprot
Q3SYE6
resolver
uniprot
Q6FH18
resolver
uniprot_entry
REG3G_HUMAN
resolver
uniprot_sec
A8K980
resolver
uniprot_sec
D6W5J6
resolver
uniprot_sec
Q3SYE4
resolver
uniprot_sec
Q3SYE6
resolver
uniprot_sec
Q6FH18
resolver
activity_regulation
ACTIVITY REGULATION: [Regenerating islet-derived protein 3-gamma 15 kDa form]: Lipopolysaccharide inhibits pore-forming activity, explaining why is bactericidal for Gram-positive but not Gram-negative bacteria. {ECO:0000250|UniProtKB:Q06141}.
uniprot
proteins
amino_acid_sequence
MLPPMALPSVSWMLLSCLILLCQVQGEETQKELPSPRISCPKGSKAYGSPCYALFLSPKSWMDADLACQKRPSGKLVSVLSGAEGSFVSSLVRSISNSYSYIWIGLHDPTQGSEPDGDGWEWSSTDVMNYFAWEKNPSTILNPGHCGSLSRSTGFLKWKDYNCDAKLPYVCKFKD
uniprot
proteins
function
FUNCTION: Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Restricts bacterial colonization of the intestinal epithelial surface and consequently limits activation of adaptive immune responses by the microbiota. {ECO:0000269|PubMed:19095652}.; FUNCTION: Acts as a hormone in response to different stimuli like anti-inflammatory signals, such as IL17A, or gut microbiome. Is secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways. Induced by IL17A in keratinocytes, regulates keratinocyte proliferation and differentiation after skin injury. In parallel, inhibits skin inflammation through the inhibition of inflammatory cytokines such as IL6 and TNF. Induced by IL22 in lung epithelial cells, inhibits cytokine production and regulates allergic airway inflammation. Induced in small intestine by inulin-enriched diet and Lactobacillus gasseri enriched microbiome, plays a role in the improvement of gut barrier function, the regulation of energy balance and glucose levels. Modulates microbiota composition in duodenal contents. Produced by nociceptor in response to endotoxins, prevents endotoxic death by targeting kynurenine pathway in microglia. {ECO:0000250|UniProtKB:O09049}.; FUNCTION: [Regenerating islet-derived protein 3-gamma 16.5 kDa form]: Has bacteriostatic activity. {ECO:0000269|PubMed:19095652}.; FUNCTION: [Regenerating islet-derived protein 3-gamma 15 kDa form]: Has bactericidal activity against L.monocytogenes and methicillin-resistant S.aureus. {ECO:0000269|PubMed:19095652}.
uniprot
proteins
mass_dalton
19330
uniprot
proteins
post_translational_modification
PTM: Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity. {ECO:0000269|PubMed:19095652}.
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15556304
uniprot
proteins
pubmed
15777617
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
19095652
uniprot
proteins
sequence_length
175
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P42854}. Cytoplasm {ECO:0000250|UniProtKB:P42854}.
uniprot
proteins