Nabp2
entrez
69917
canonical
uniprot
Q8R2Y9
canonical
ensembl
ENSMUSG00000025374
resolver
ensp
ENSMUSP00000026439
resolver
ensp
ENSMUSP00000128634
resolver
ensp
ENSMUSP00000241644
resolver
enst
ENSMUST00000026439
resolver
enst
ENSMUST00000164199
resolver
genesymbol
Nabp2
resolver
genesymbol_syn
Obfc2b
resolver
genesymbol_syn
Ssb1
resolver
uniprot_entry
SOSB1_MOUSE
resolver
amino_acid_sequence
MTTETFVKDIKPGLKNLNLIFIVLETGRVTKTKDGHEVRTCKVADKTGSINISVWDDVGNLIQPGDIIRLTKGYASVFKGCLTLYTGRGGDLQKIGEFCMVYSEVPNFSEPNPEYNTQQAPNKSVQNNDNSPTAPQATTGPPAASPASENQNGNGLSTQLGPVGGPHPSHTPSHPPSTRITRSQPNHTPSGPPGPSSNPVSNGKETRRSSKR
uniprot
proteins
function
FUNCTION: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways (By similarity). {ECO:0000250|UniProtKB:Q9BQ15}.
uniprot
proteins
mass_dalton
22628
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by ATM in response to DNA damage. Phosphorylation prevents degradation by the proteasome, hence stabilization of the protein and accumulation within cells (By similarity). {ECO:0000250|UniProtKB:Q9BQ15}.; PTM: Ubiquitinated in a FBXL5-dependent manner, leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q9BQ15}.
uniprot
proteins
protein_family
SOSS-B family
uniprot
proteins
protein_family
SOSS-B1 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16533169
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
212
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Localizes to nuclear foci following DNA damage. Foci formation is not cell-cycle dependent. Partial colocalization with RAD51 after ionizing radiation treatment (By similarity). {ECO:0000250|UniProtKB:Q9BQ15}.
uniprot
proteins