Atp6ap2
entrez
70495
canonical
uniprot
Q9CYN9
canonical
ensembl
ENSMUSG00000031007
resolver
ensp
ENSMUSP00000033313
resolver
enst
ENSMUST00000033313
resolver
genesymbol
Atp6ap2
resolver
genesymbol_syn
Atp6ip2
resolver
uniprot
A2BDN5
resolver
uniprot
Q1XID4
resolver
uniprot
Q8BVU6
resolver
uniprot
Q91YU5
resolver
uniprot_entry
Q1XID4_MOUSE
resolver
uniprot_entry
RENR_MOUSE
resolver
uniprot_sec
A2BDN5
resolver
uniprot_sec
Q8BVU6
resolver
uniprot_sec
Q91YU5
resolver
amino_acid_sequence
MAVLVVLLFFLVAGALGNEFSILRSPGSVVFRNGNWPIPGDRIPDVAALSMGFSVKEDLSWPGLAVGNLFHRPRATIMVMVKGVDKLALPAGSVISYPLENAVPFSLDSVANSIHSLFSEETPVVLQLAPSEERVYMVGKANSVFEDLSVTLRQLRNRLFQENSLLNSLPLNSLSRNNEVDLLFLSELQVLHDISSLLSRHKHLAKDHSPDLYSLELAGLDELGKRYGEDSEQFRDASKILVDALQKFADDMYSLYGGNAVVELVTVKSFDTSLVRKSRTILEAKQENTQSPYNLAYKYNLEYSVVFNLVLWIMIGLALAVIITSYNIWNMDPGYDSIIYRMTNQKIRID
uniprot
proteins
function
FUNCTION: Multifunctional protein which functions as a renin, prorenin cellular receptor and is involved in the assembly of the lysosomal proton-transporting V-type ATPase (V-ATPase) and the acidification of the endo-lysosomal system (By similarity). May mediate renin-dependent cellular responses by activating ERK1 and ERK2 (By similarity). By increasing the catalytic efficiency of renin in AGT/angiotensinogen conversion to angiotensin I, may also play a role in the renin-angiotensin system (RAS) (By similarity). Through its function in V-type ATPase (v-ATPase) assembly and acidification of the lysosome it regulates protein degradation and may control different signaling pathways important for proper brain development, synapse morphology and synaptic transmission (PubMed:26376863, PubMed:29127204, PubMed:30985297). {ECO:0000250|UniProtKB:O75787, ECO:0000269|PubMed:26376863, ECO:0000269|PubMed:29127204, ECO:0000269|PubMed:30985297}.
uniprot
proteins
mass_dalton
39092
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250|UniProtKB:O75787}.; PTM: Proteolytically cleaved by a furin-like convertase in the trans-Golgi network to generate N- and C-terminal fragments. {ECO:0000250|UniProtKB:O75787}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26376863
uniprot
proteins
pubmed
29127204
uniprot
proteins
pubmed
30985297
uniprot
proteins
sequence_length
350
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:26376863}; Single-pass type I membrane protein {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:26376863, ECO:0000269|PubMed:30985297}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:26376863}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, dendritic spine membrane {ECO:0000269|PubMed:26376863}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000269|PubMed:26376863}. Endosome membrane {ECO:0000269|PubMed:30985297}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:Q6AXS4}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q6AXS4}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 303..323; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins