Rit2
entrez
19762
canonical
uniprot
P70425
canonical
ensembl
ENSMUSG00000057455
resolver
ensp
ENSMUSP00000114323
resolver
enst
ENSMUST00000153060
resolver
genesymbol
Rit2
resolver
genesymbol_syn
Rin
resolver
genesymbol_syn
Roc2
resolver
uniprot
Q3UST1
resolver
uniprot
Q3UUP4
resolver
uniprot
Q8BQT5
resolver
uniprot
Q9QWX5
resolver
uniprot_entry
RIT2_MOUSE
resolver
uniprot_sec
Q3UST1
resolver
uniprot_sec
Q3UUP4
resolver
uniprot_sec
Q8BQT5
resolver
uniprot_sec
Q9QWX5
resolver
activity_regulation
ACTIVITY REGULATION: Alternates between an inactive form bound to GDP and an active form bound to GTP.
uniprot
proteins
amino_acid_sequence
MEVENEAHCCPGSSSGGSREYKVVMLGAGGVGKSAVTMQFISHQFPDYHDPTIEDAYKTQVRIDNEPAYLDILDTAGQAEFTAMREQYMRGGEGFIICYSVTDRQSFQEAAKFKELIFQVRHTYEIPLVLVGNKIDLEQFRQVSTEEGMNLARDYNCAFFETSAALRFGIDDAFQGLVREIRRKESMLSLVERKLKRKDSLWKKIKASLKKKRENML
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Binds and exchanges GTP and GDP. Binds and modulates the activation of POU4F1 as gene expression regulator. {ECO:0000269|PubMed:12934100}.
uniprot
proteins
mass_dalton
24802
uniprot
proteins
mutagenesis
MUTAGEN 34; /note="S->N: Dominant negative. Loss of interaction with AFDN, RLF and RALGDS."; /evidence="ECO:0000269|PubMed:10545207"; MUTAGEN 52; /note="T->A: Loss of interaction with AFDN, RLF and RALGDS; when associated with L-78."; /evidence="ECO:0000269|PubMed:10545207"; MUTAGEN 78; /note="Q->L: Constitutively active. Dramatic reduction of the rate of GTP hydrolysis."; /evidence="ECO:0000269|PubMed:10545207
uniprot
proteins
protein_family
Ras family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10545207
uniprot
proteins
pubmed
12934100
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23805044
uniprot
proteins
pubmed
8824319
uniprot
proteins
sequence_length
217
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23805044}. Cell membrane {ECO:0000269|PubMed:23805044}. Note=Colocalizes with PLXNB3 at the plasma membrane. {ECO:0000250|UniProtKB:Q99578}.
uniprot
proteins