THEM5
entrez
284486
canonical
uniprot
Q8N1Q8
canonical
ensembl
ENSG00000196407
resolver
ensp
ENSP00000357807
resolver
enst
ENST00000368817
resolver
genesymbol
THEM5
resolver
genesymbol_syn
ACOT15
resolver
hgnc
HGNC:26755
resolver
uniprot
Q5T1C3
resolver
uniprot_entry
THEM5_HUMAN
resolver
uniprot_sec
Q5T1C3
resolver
amino_acid_sequence
MIRRCFQVAARLGHHRGLLEAPRILPRLNPASAFGSSTDSMFSRFLPEKTDLKDYALPNASWCSDMLSLYQEFLEKTKSSGWIKLPSFKSNRDHIRGLKLPSGLAVSSDKGDCRIFTRCIQVEGQGFEYVIFFQPTQKKSVCLFQPGSYLEGPPGFAHGGSLAAMMDETFSKTAFLAGEGLFTLSLNIRFKNLIPVDSLVVMDVELDKIEDQKLYMSCIAHSRDQQTVYAKSSGVFLQLQLEEESPQ
uniprot
proteins
ec_number
3.1.2.2
uniprot
proteins
function
FUNCTION: Has acyl-CoA thioesterase activity towards long-chain (C16 and C18) fatty acyl-CoA substrates, with a preference for linoleoyl-CoA and other unsaturated long-chain fatty acid-CoA esters (PubMed:22586271). Plays an important role in mitochondrial fatty acid metabolism, and in remodeling of the mitochondrial lipid cardiolipin (PubMed:22586271). Required for normal mitochondrial function (PubMed:22586271). {ECO:0000269|PubMed:22586271}.
uniprot
proteins
mass_dalton
27677
uniprot
proteins
mutagenesis
MUTAGEN 160; /note="G->A: Strongly reduces enzyme activity. Abolishes enzyme activity; when associated with A-183."; /evidence="ECO:0000269|PubMed:22586271"; MUTAGEN 167; /note="D->A: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:22586271"; MUTAGEN 183; /note="T->A: Reduces enzyme activity. Abolishes enzyme activity; when associated with A-160."; /evidence="ECO:0000269|PubMed:22586271
uniprot
proteins
protein_family
THEM4/THEM5 thioesterase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
22586271
uniprot
proteins
sequence_length
247
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:22586271}.
uniprot
proteins