Fam83d
entrez
71878
canonical
uniprot
Q9D7I8
canonical
ensembl
ENSMUSG00000027654
resolver
ensp
ENSMUSP00000029183
resolver
genesymbol
Fam83d
resolver
uniprot
A2AC91
resolver
uniprot
Q3TXE0
resolver
uniprot
Q6P396
resolver
uniprot
Q8BYC0
resolver
uniprot_entry
FA83D_MOUSE
resolver
uniprot_sec
A2AC91
resolver
uniprot_sec
Q3TXE0
resolver
uniprot_sec
Q6P396
resolver
uniprot_sec
Q8BYC0
resolver
amino_acid_sequence
MAARFELLDDLPAACLSPCGPPNPTELFSEARRLALEQLLAGGPDAWAAFLRRERLGRFLNADEVREVLGAAERPGEDGAAVAEDSFGSSHECSSGTYFPEQSDLEPPALELGWPSFYQGAYRGATRVEAHFQPRGAGAGGPYGCKDALRQQLRSAREVIAVVMDVFSDIDIFRDLQESCRKRGVAVYILLDQTLLPHFLDMCMDLRVHPEQEKLMTVRTITGNIYYARSGTKVVGKVHEKFTLIDGIRVATGSYSFTWTDGKLNSSNLVILSGQVVEHFDLEFRILYAQSEPISSKLLSNFQINSKFDHLADRKPQSKEPTLGNLLRMRLARLSSTPRKSNLGPEEPPKDRAKPKRPDSEASTISDEDYFHSHKDQLEDSKVADAATQTEPREEMAAVSLSEVGTQTSSSMMCVGTQTTVVTRAASSQATVWSKSTTTQTEADESFLPQGAQSKEGSPASKMSVSRSSSVRSSSSVSSQGSLASSVSSHVSLTAADLHTPAYPKYLGLGTPHLDLCLRDSFRNLSKERQVHFTGIRSRLTQMLTVLSRRTLFTEHYLSYSPGSFTRASTNLVSVRDIALYPPYQ
uniprot
proteins
function
FUNCTION: Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (By similarity). May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (By similarity). May also be important for proper chromosome congression and alignment during mitosis through its interSACK1action with KIF22 (By similarity). {ECO:0000250|UniProtKB:Q9H4H8}.
uniprot
proteins
mass_dalton
64324
uniprot
proteins
post_translational_modification
PTM: Phosphorylated during mitosis. {ECO:0000269|PubMed:31338967}.
uniprot
proteins
protein_family
SACK1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
31338967
uniprot
proteins
sequence_length
585
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H4H8}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9H4H8}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q9H4H8}. Note=Primarily cytoplasmic during interphase, but at prophase, associates with spindle microtubules, with a clear concentration toward the spindle poles. It persists on spindle microtubules through metaphase and anaphase. {ECO:0000250|UniProtKB:Q9H4H8}.
uniprot
proteins