Kcnmb3
entrez
310303
canonical
uniprot
A7VL23
canonical
ensembl
ENSRNOG00000027836
resolver
ensp
ENSRNOP00000055650
resolver
enst
ENSRNOT00000058860
resolver
genesymbol
Kcnmb3
resolver
uniprot_entry
KCMB3_RAT
resolver
amino_acid_sequence
MQPFSIPVQITLQGGRRRQGRTALPASGISNGDPLKVHPKLPSSAGEDRATLLGIAMMASSVLMFFLLGTTVLKPFMLSSPREESNCTTVHTHIADDWLDFAFTCEGSCQGQGTYPCLQVFVNLSHSGQKVLLHYDEEAIRTNPKCFYTPKCHGDRDHLLNSALDIKEFFDHNNGTFPCFYSPDGPLGVVLRKSGHKVVFHCLFWPLLTLLGGALIVGLVRLTQHLSFQCEKYRAVVRA
uniprot
proteins
function
FUNCTION: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. May partially inactivate the current of KCNBMA. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer (By similarity). {ECO:0000250|UniProtKB:Q9NPA1}.
uniprot
proteins
mass_dalton
26447
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q9NPA1}.; PTM: The extracellular domain contains disulfide bond essential for the gating mechanism. {ECO:0000250|UniProtKB:Q9NPA1}.
uniprot
proteins
protein_family
KCNMB (TC 8.A.14.1) family
uniprot
proteins
protein_family
KCNMB3 subfamily
uniprot
proteins
sequence_length
239
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9NPA1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NPA1}.
uniprot
proteins
transmembrane_region
TRANSMEM 52..72; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 198..218; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins