Men1
entrez
17283
canonical
uniprot
O88559
canonical
ensembl
ENSMUSG00000024947
resolver
ensp
ENSMUSP00000058149
resolver
ensp
ENSMUSP00000077272
resolver
ensp
ENSMUSP00000078306
resolver
ensp
ENSMUSP00000109130
resolver
enst
ENSMUST00000113502
resolver
genesymbol
Men1
resolver
uniprot
A0A0R4J1I3
resolver
uniprot
Q3U491
resolver
uniprot
Q8CI72
resolver
uniprot
Q91UZ7
resolver
uniprot_entry
A0A0R4J1I3_MOUSE
resolver
uniprot_entry
MEN1_MOUSE
resolver
uniprot_sec
Q3U491
resolver
uniprot_sec
Q8CI72
resolver
uniprot_sec
Q91UZ7
resolver
amino_acid_sequence
MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGPNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYQDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLETGEERTGEQAQGTQGQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVHIVSREAEAAEAEEPWGDEAREGRRRGPRRESKPEEPPPPKKPALDKGPGSGQSAGSGPPRKTSGTVPGTTRGGQEVGNAAQAPAPAASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL
uniprot
proteins
function
FUNCTION: Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression (By similarity). May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair. {ECO:0000250|UniProtKB:O00255, ECO:0000269|PubMed:16415155}.
uniprot
proteins
mass_dalton
67501
uniprot
proteins
pubmed
10341092
uniprot
proteins
pubmed
10524203
uniprot
proteins
pubmed
10612420
uniprot
proteins
pubmed
11158604
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16415155
uniprot
proteins
pubmed
9824159
uniprot
proteins
pubmed
9893060
uniprot
proteins
pubmed
9989505
uniprot
proteins
sequence_length
611
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9824159}. Note=May be perinuclear in testis. {ECO:0000269|PubMed:9824159}.
uniprot
proteins