Riok3
entrez
66878
canonical
uniprot
Q9DBU3
canonical
ensembl
ENSMUSG00000024404
resolver
ensp
ENSMUSP00000025270
resolver
enst
ENSMUST00000025270
resolver
genesymbol
Riok3
resolver
uniprot
Q3UI51
resolver
uniprot
Q8CIC1
resolver
uniprot_entry
RIOK3_MOUSE
resolver
uniprot_sec
Q3UI51
resolver
uniprot_sec
Q8CIC1
resolver
amino_acid_sequence
MDLVGVSSPEPGPAAAWGPSKCPWATPQNTVSCSLTEVMSEELAKELQLEEEAAAFPEVVVAEGPFISGENIDTSSDLMLAQMLQMEFDREYDAQLRREEKKFNGDSKVSISFENYRKVHPFEDSDSSEDEVDWQDTRDDPYRPAKPIPTPKKGFIGKGKDITTKHDEVVCGRKNTARMENFAPGFQVGDGIGMDLKLSNHVFNALKQHAYSEERRSARLHEKKEHSTAEKAVDPKTRLLMYKMVNSGMLETITGCISTGKESVVFHAYGGSLEDEKEDGKAIPTECAIKVFKTTLNEFKNRDKYIKDDFRFKDRFSKLNPRKIIRMWAEKEMHNLTRMQKAGIPCPTVVLLKKHILVMSFIGHDQVPAPKLKEVKLSNEEMKDAYYQTLHLMQQLYNECTLVHADLSEYNMLWHAGKVWLIDVSQSVEPTHPHGLEFLFRDCRNVSQFFQKGGVTEALNERELFNAVSGLNISADNEADFLAEIEALEKMNEDHIQKNGRKAASFLKDDGSPPVLSAD
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase involved in a ribosome quality control that takes place when ribosomes have stalled, leading to 18S non-functional rRNA decay and degradation of the 40S ribosomal subunit. Acts downstream of RNF10: specifically recognizes and binds RPS2/us5 and RPS3/us3 monoubiquitinated by RNF10, promoting degradation of the 40S ribosomal subunit in a kinase-dependent manner. The RNF10-RIOK3 ribosome quality control takes place in response to ribosome subunit imbalance or downstream the EIF2AK4/GCN2-mediated integrated stress response (ISR). Also involved in regulation of type I interferon (IFN)-dependent immune response, possibly by acting as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling. Can inhibit CASP10 isoform 7-mediated activation of the NF-kappa-B signaling pathway. {ECO:0000250|UniProtKB:O14730}.
uniprot
proteins
mass_dalton
58704
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated (in vitro). {ECO:0000250|UniProtKB:O14730}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
RIO-type Ser/Thr kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
519
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O14730}.
uniprot
proteins