Abca13
entrez
268379
canonical
uniprot
Q5SSE9
canonical
ensembl
ENSMUSG00000004668
resolver
ensp
ENSMUSP00000040465
resolver
genesymbol
Abca13
resolver
uniprot
Q80T20
resolver
uniprot
Q8BHZ2
resolver
uniprot
Q8CB91
resolver
uniprot_entry
ABCAD_MOUSE
resolver
uniprot_sec
Q80T20
resolver
uniprot_sec
Q8BHZ2
resolver
uniprot_sec
Q8CB91
resolver
amino_acid_sequence
MGHAGRQFQALLWKNWICRLRHPVLSLAEFFWPCILFMILTVLRFQEPPRHRENCYLQARDLPSRGVLPFVQGLLCNTGSSCRNISFESSMDHHFRLSRFQTASDDRKVSSLAFLNEIQDLAEDIFETMDKAKNLQKLWLKRSETPGSSYGSGFLTMDLNKTEDVISKLESLHQQPHIWDFLHSLPRLYMSSAHLEDSMGAVTHFLQAGLNSLASLGDLDWLPLHQTIPQVSRHVLNVTISTLRFLQQHSAVVNETIYHLSLKNIVWDPQKVQSDLKSQFGFNDFQMQHILNYSAKLEEIPTHSFLERMVCSILSNTSEDEAESKGYRADCHPKWSAVKNYIIHAVSWLKLYGQVFDQWQQGSLLQSLLAGASHSLAALREQFKQQSESWKVVEALHTALLILNDSLAADVPRDYHLFPQIFQHLSKLQHALSDLSPWPALKRLLLLDTVLRNMIAQDLRFVQEFLSYLERSAKDFIPAGSEGWRLEKDVLFQGLNQLLTKNASALCLNGHLSQEAALPTGNSSIWRSVWGVLCHTLFFNETSVLNELLRAVKDAGHSLQAVIAGHTNGSVSEHGGHFGWQDLGTQLSEISLTCSRVFQLPRADTSPENSFSPGGCESQLVSIVVSHILEDVQMSTQKKSYWKILSKIVRKTCELARYVNMNGSLQNSGLISFSEDSPCYTQDMNWKVIIDNYFVFFNNFKKSPITSITTAFNFTKHLLVVDQKLHTLENGQMNILLSFVEFVEKLLSNPSGSFPAPEFDNLSSLTELVFNATVSWLTHLKRLKADSHDAAPQELLEFDHLVTEKIQRLKNHWMKKGSKNILNFLELILLEMNSELQEFRLNGIPQEERTNIEGFSTLVNFSVAEYEKILCKRFTFSQLFHSYWPKSPAINADFIHLSETIIQSLCGLSFLTQEQVSIALNTVSALQNTSELFSALSEPQKQELDNFLTHVYINVFKDKNIALFLQTYSSFYRYIHKFFNIQNREPLIAYFTQISRHILDLIKQFNIQNIREALSFLSETTEALGMISEVSHCQQLLSIFNFLELQAWSLMARGGPAEAVIHASLTGLKQLFAADEGFRVSLLQYVTQCFNGSAATLVASECFIQENATISSVNYSGNEGSSLPFPWTQFFSNLSVNGSAISEFTAIHCTLSWIQTWAEIWRSIAQIFKLELSIFTPLHVGITQLLDDLGNYGNISKDCQGIVPTYLTARLILNLFRNITQENNFHDWDGLQDLRDLWVAFGNELTTVQSLNLDQVEKTFITMETSLHQLKTFPMKINASREFLYSLFDVFIELSKASDYVDRNVELINNFLSDDLPDHQAKFASIIKELKETILFLRHVSQGRTLSACADIFQRLTELIFEDSLLLVNTSNKPEHILAMLSSMFSSKNTSSSLEGCITWIDIINHLCIMYNSSSLPSHSYNILGSFKDMGDKMSSALNILTWMLNKKRPICPWNESNINCVNIYLKDITDFLNIIVTTGLEKENVPNVEILLSLFNDSTKQVDMIITNLTEDLNVASQSNWKHFKDLLLRPTEMSDDIPDQFQNIWQHIIALGKEMQKLLKGIFHSVLGNNFSSNTETMFSVFSTSPKEGDISHLGKSIYNLANYFALNLTHNLQNSSEVFPHEILKAVDLSIQLTRDVFNFLMPAVHFNIPQNSDHAQTLKKVTSLMQSLKKADIELLVGQLGENSEILMSFFKNLSRSGIDNLGVNMLVGLVEKFVDSSHSWSVSHLLRLSRLLPKDVVDTVLDVYYALPHIVGLLRRIVDKNITESLRDVYNFTLLHGITMFKITKEDFADVVKTLLDAVELVSDEPAIVPEALMCLTRVWCANYTTFRLEKNPKVEDCNIQRHMPSSFFHMVTSLLDLLHLPPPSDSQCIGEKYAVEITRRLACAVHDLADWNSILSELLEIFHVKNLLVKTLQGFWHKVLLFMSSSGIQGNGSIPELCPTSTIKQGALQIIEKLKYVNFTKFSLGETILDRLGNLDRILSLTKGTEKSVQNNIYLNLERLFKLISATWTLRNSTHYLLSPITNFLNGNYTGWSLFKNNRTSSNIEELWLDFKQIPKDLTSNWSLGQLLSDINKNIQGAGLQNTTVQLPQLLELLDSSPLKTSEIIEGFLFLIKPWLREYENGDFFRFIQSLLNAVASGNSTDVSRLARDFTMYLGYLRNQSREGNFDVGFFSHMLDQEHLTDLPVVQRLLESIVMNSVSSFAALSQETPPSFSGTNLQIADLMNLILKHAQSKNHAEAEGSTEDFLKQLPETFFSSVINGLHSDVTAEVSFVPRDKILEILKLDPFLTWMNKNPLMNIFSGLKTLYYLIKSSFSLDNRELSGVLKDLSHTHPWETTVKTDAEGHLDFFSVVTQFLSQVNSSEDLSKFNQNLRSVLYLVQESSTEMATIIDTVLHSTSGACYSPYPMLQHSTVAKLSDLFSDVNSSFPLRSREILESTMRLFGTISQVGEESHVLESALEIFRTLTMLVNSTVELGHLASTADSMVRLLNLAKIVSRKMATMLGTLSISSTEDSGKFLDTLYSFMLQSVPHHVKQITTLKKGDPFIVEKTKDLLIPFLDLAFGMIGVTPNVSQDSDVFSMPFSILSYINQSRDFSETLEGMAENLISIKISLRDWEHFVAMIKNRTQNFSIDAADLWEEILGCLVPISNITTQMDFLKLYELSSTSHPQVPKQERTHDVIRYLDGMLTDNGTERETFLKMVIDLTLQALWNGLKEDNWDIFNLLLAFAQHPNDLLKAIESVVAVSSGIHSDYPDDFNQDSFSDLSLIQNTTRYQLAKAVLIGLGKAGFSREGLPLNNTQWTHFTRTLFHPDYNSFPNSTPHQNVTSAKDGRTKDEMMVILHGSEPMPYLQRFLKALFVSIEHWQEVPQAEQSVFEMCQVFQQLQKPMKTVKMLQRVEMMALRVLIIFAENPSLTKDILCAALSCKQGAMRHLILAALQGVTLVHRHYQEIGKIWFSPDQLDCERLSRNLSSALEGFKSILDNASSHRCTCQPLVGVVQQHIRRLTKSLEEVWMSKIPAMTFLSNFTVTEDVKIKDLMRNITKFTEDLRSFFHISEETIHSILEANISHSKVLSSVLTIALSGKCDEEILHLLLTFPESEKSWFVTRELCSLPGSQVFSLLVMMGQNLNLRNLIYKTLIPSEANGLLKSLLDVVASLSSILARAQHALEYLPEFLHTFKITALLDMPDFQQVSSKGQTRSSAFASFQSVMKLLCKDQESFLSNSNMFINLPRVNELLEDNKEKFNIPHDSTPFCLKLYQEILQSPNGALVWSFLKPVLHGKILYTPNSPEINEVIQKANYTFYFVDKIKVLSETFLKISKLFQGSGNGQMFNQLQDALRNKFIRNFVESQLHIDMDKLTEDLQTYGRMLDKMFNHVEAGHFRFLGGMLANLSSCVVLDRFQAVETVDTLETKAHELMQQNSFLASIIFNSSLRHRHIRSAPHKLPPHVTYTIRTNVLYSMRTDMIKNPSWKFHPQNLPAGGFKYNYIFVPLQDMIERAIIVVQTGQESLEPTTQAQAAPYPCHTSDLFLNNVGFFFPLIMMLTWMVAVASMVRKLVYEREIQIEEYMRMMGLHPTIHFLSWFLENMATLALSSAALAVILKMSGIFMHSDAFIIFLYLLDFGVSAVMMSYFLSVFFNQANTAALCTSLGYMISFLPYVVLLVLHNQLSFAIQTLLCLLSTTAFGQGVFFITFLEGQEEGIQWGNMYRAPEPGGMTFGWVCWMILFDAILYFLGGWYFSNLVPGTFGLGKPWYFPFTASYWKSICGLMERRRCSLSSGLFFFNEDFGNKGLSQQNGPGEMEGGNPGVALISVTKEYEDHKVAVQELTLTFHRDQITALLGTNGAGKTTIISMLMGLFPPTSGTITINGKNLQTDLSKVREELGVCPQQDVLLDNLTVREHLMLFASIKAPWWTTKELQQQVNKTLDEVELTQHQHKPAGVLSGGMKRKLSIGIAFMGMSKTVVLDEPSSGVDPCSRRSLWDILLKYREGRTIIFTTHHLDEAEMLSDHVAVLQQGRLRCYAPPADLKETYGQGLTLTLSKQPSILETQEPKDVARVTSLIQIYIPQAFLKDSCGGELTYTIPKDADRTCFKGLCQALDQNLQHLHLTGYGISDTTLEEVFLMLLQDTNKKSYITPDNKVEPQNERPVGPLSPHNVSPLSTPPEGALPEPIGGCQLLLGQAVALLRKRLLHTLRAWKSTTSDLLLPVLFVALAMGLFMVQPLAITYPPLKLTPGHYETAETYFFSSGNHGPDLTHVLLRKFRDQDPVCADAFRMNSSSWHRDPYSGPESQDSCGCLKCPNKSAGAPSLTNCLGHTLLNLSGYDVEEYLLVPSAKPRLGGWSFGGQIPNDAEDVKTNTSKPRTLAKVWYNQKGFHSLPSYLNHLNNLILWHHLPANAVDWRQYGITLYSHPYGGALLNEDRILESIRQCGVALCIVLGFSILSASIGSSVVRDRVTGAKRLQHISGLGHRTYWLINFLYDMLFYLVSVCLCVAVIGAFQLTAFTFRENLAATALLLALFGYAMIPWMYLMSRIFSSSDVAFISYISLNFIFGLCTMLMTTMPRLLAIISKAQNLQKIYNVLKWAFTIFPQFCLGQGLIELCYNQIKYDLTHNFGIDSYVSPFEMNFLGWIFVELTLQGTFLLLLRLMLHGDLLRWPRDHSVLQDIVKPAKDIDVETEQMRVLEGRTGGDMMVLCNLSKSYRSVFGGKTTAVHGISLGIPRGECFGLLGVNGAGKSTTFKILNGETPPSSGYTVIRTPQGDMVDLASAGKAGILIGYCPQQDALDELLTGWEHLQYYCRLRGIPKQYIPEVAADLVRRLHLESHVDKPVATYSGGTRRKLSTALALVGKPDILLLDEPSSGMDPCSKRYLWQTITQEVRDGCAAVLTSHSMEECEALCTRLAIMVDGSFRCLGPPQHIKNRFGDGYTVKVWLHKEGSQPSAVSDCLKLHFPGIQFKGQRLNLLEYHVQKSWECLADLFKVLENNKSLLNIEHYSISQTTLEQVFVNFATEQLQTPCFPVDSPSTDAQHPCYTRI
uniprot
proteins
ec_number
7.6.2.-
uniprot
proteins
function
FUNCTION: May mediate the cholesterol and gangliosides transport from the plasma membrane to intracellular vesicles in an ATP hydrolysis dependent manner, thus playing a role in their internalization by endocytic retrograde transport and may also participate in the endocytosis of synaptic vesicle in cortical neurons. {ECO:0000269|PubMed:33478937}.
uniprot
proteins
mass_dalton
568897
uniprot
proteins
mutagenesis
MUTAGEN 3577; /note="H->P: Does not affect protein expression. Decreases intracellular cholesterol accumulation in the vesicle."; /evidence="ECO:0000269|PubMed:33478937"; MUTAGEN 3849; /note="K->M: Does not affect intracellular vesicle localization. Affects cholesterol internalization."; /evidence="ECO:0000269|PubMed:33478937"; MUTAGEN 3999; /note="T->A: Does not affect protein expression. Affects intracellular vesicles localization. Impairs intracellular cholesterol accumulation in the vesicle."; /evidence="ECO:0000269|PubMed:33478937"; MUTAGEN 4735; /note="K->M: Does not affect intracellular vesicle localization. Affects cholesterol internalization."; /evidence="ECO:0000269|PubMed:33478937"; MUTAGEN 4818; /note="R->C: Does not affect protein expression. Decreases intracellular cholesterol accumulation in the vesicle."; /evidence="ECO:0000269|PubMed:33478937
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
pubmed
12697998
uniprot
proteins
pubmed
12706902
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
33478937
uniprot
proteins
sequence_length
5034
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000269|PubMed:33478937}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..43; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 3536..3556; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 3590..3610; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 3616..3636; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 3647..3667; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 3677..3697; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 3720..3740; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 4206..4226; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 4432..4452; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 4478..4498; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 4510..4530; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 4540..4560; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 4581..4601; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 4625..4645; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins