Prdx2
entrez
29338
canonical
uniprot
P35704
canonical
ensembl
ENSRNOG00000003520
resolver
ensp
ENSRNOP00000004799
resolver
enst
ENSRNOT00000004799
resolver
genesymbol
Prdx2
resolver
genesymbol_syn
Tdpx1
resolver
uniprot
A0A0G2JSH9
resolver
uniprot
Q6PDV3
resolver
uniprot_entry
A0A0G2JSH9_RAT
resolver
uniprot_entry
PRDX2_RAT
resolver
uniprot_sec
Q6PDV3
resolver
amino_acid_sequence
MASGNAHIGKPAPDFTGTAVVDGAFKEIKLSDYRGKYVVLFFYPLDFTFVCPTEIIAFSDHAEDFRKLGCEVLGVSVDSQFTHLAWINTPRKEGGLGPLNIPLLADVTKSLSQNYGVLKNDEGIAYRGLFIIDAKGVLRQITVNDLPVGRSVDEALRLVQAFQYTDEHGEVCPAGWKPGSDTIKPNVDDSKEYFSKHN
uniprot
proteins
ec_number
1.11.1.24
uniprot
proteins
function
FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). {ECO:0000250|UniProtKB:P32119}.
uniprot
proteins
mass_dalton
21784
uniprot
proteins
post_translational_modification
PTM: The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) instead of its condensation to a disulfide bond. It can be reactivated by forming a transient disulfide bond with sulfiredoxin SRXN1, which reduces the cysteine sulfinic acid in an ATP- and Mg-dependent manner. {ECO:0000250|UniProtKB:P32119, ECO:0000250|UniProtKB:Q06830}.; PTM: Acetylation increases resistance to transition to high molecular-mass complexes. Deacetylated by HDAC6 which decreases reducing activity. {ECO:0000250|UniProtKB:P32119}.
uniprot
proteins
protein_family
AhpC/Prx1 subfamily
uniprot
proteins
protein_family
Peroxiredoxin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8041738
uniprot
proteins
sequence_length
198
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P32119}.
uniprot
proteins