Oxgr1
entrez
290493
canonical
uniprot
Q6Y1R5
canonical
ensembl
ENSRNOG00000075479
resolver
ensembl
ENSRNOG00055011953
resolver
ensembl
ENSRNOG00060008344
resolver
ensembl
ENSRNOG00065007876
resolver
ensp
ENSRNOP00000098804
resolver
ensp
ENSRNOP00055016385
resolver
ensp
ENSRNOP00060010578
resolver
ensp
ENSRNOP00065009068
resolver
enst
ENSRNOT00000150824
resolver
enst
ENSRNOT00055020326
resolver
enst
ENSRNOT00060013867
resolver
enst
ENSRNOT00065012368
resolver
genesymbol
Oxgr1
resolver
genesymbol_syn
Gpr80
resolver
genesymbol_syn
P2y15
resolver
uniprot_entry
OXGR1_RAT
resolver
amino_acid_sequence
MIETLDSPANDSDFLDYITALENCTDEQISFKMQYLPVIYSIIFLVGFPGNTVAISIYVFKMRPWKSSTIIMLNLALTDLLYLTSLPFLIHYYASGENWIFGDFMCKFIRFGFHFNLYSSILFLTCFSLFRYIVIIHPMSCFSIQKTRWAVVACAGVWVISLVAVMPMTFLITSTTRTNRSACLDLTSSDDLTTIKWYNLILTATTFCLPLLIVTLCYTTIISTLTHGPRTHSCFKQKARRLTILLLLVFYVCFLPFHILRVIRIESRLLSISCSIESHIHEAYIVSRPLAALNTFGNLLLYVVVSNNFQQAFCSAVRCKAIGDLEQAKKDSCSNNP
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for dicarboxylates and amino dicarboxylates, such as alpha-ketoglutarate, itaconate and leukotriene E4. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as phospholipase C. OXGR1 is coupled to G(q) G proteins and mediates production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (By similarity). Activation by alpha-ketoglutarate produced by proximal tubule renal cells upon metabolic alkalosis initiates an intrarenal paracrine signaling pathway that drives transepithelial salt reabsorption and bicarbonate secretion by SLC26A4/pendrin-positive intercalated cells (By similarity). Also acts as a regulator of vasodilatation in vascular smooth muscle cells: following activation by alpha-ketoglutarate, couples to GNAQ/G(q), initiating a signaling that activates MYLK/MLCK, thereby promoting MYL9 phosphorylation and vascular smooth muscle cell contraction and limiting vasodilation. Receptor for itaconate, a metabolite produced by myeloid lineages. In the respiratory epithelium, couples the binding of itaconate to the activation of GNA11/G(11) and downstream intracellular Ca(2+) release, leading to mucocilliary clearance of airborne pathogens. Receptor for leukotriene E4 (LTE4) produced by mast cells upon allergic inflammation (By similarity). Binds with high affinity to LTE4 and elicits mucin release from pulmonary epithelium in response to airborne fungi allergens. Regulates mucin-producing goblet cell homeostasis (By similarity). {ECO:0000250|UniProtKB:Q6IYF8, ECO:0000250|UniProtKB:Q96P68}.
uniprot
proteins
mass_dalton
38377
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15001573
uniprot
proteins
sequence_length
337
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q96P68}; Multi-pass membrane protein {ECO:0000255}. Note=Upon itaconate binding, internalizes via endocytosis in a beta-arrestin dependent manner. {ECO:0000250|UniProtKB:Q96P68}.
uniprot
proteins
transmembrane_region
TRANSMEM 31..55; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q96P68"; TRANSMEM 70..94; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q96P68"; TRANSMEM 99..127; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q96P68"; TRANSMEM 153..173; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q96P68"; TRANSMEM 191..215; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q96P68"; TRANSMEM 243..266; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q96P68"; TRANSMEM 279..303; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q96P68
uniprot
proteins