Sel1l
entrez
20338
canonical
uniprot
Q9Z2G6
canonical
ensembl
ENSMUSG00000020964
resolver
ensp
ENSMUSP00000021347
resolver
ensp
ENSMUSP00000129384
resolver
genesymbol
Sel1l
resolver
genesymbol_syn
Sel1h
resolver
genesymbol_syn
mKIAA4137
resolver
uniprot
Q5DTL8
resolver
uniprot
Q6GTY4
resolver
uniprot
Q9DBD8
resolver
uniprot_entry
Q5DTL8_MOUSE
resolver
uniprot_entry
Q6GTY4_MOUSE
resolver
uniprot_entry
SE1L1_MOUSE
resolver
uniprot_sec
Q9DBD8
resolver
amino_acid_sequence
MQVRVRLSLLLLCAVLLGSAAATSDDKTNQDDSLDSKSSLPTDESVKDHTTTGKVVAGQIFVDSEEAEVESLLQDEEDSSKTQEEEISFLESPNPSSKTYEELKRVRKPVLTAIEGTAHGEPCHFPFLFLDKEYDECTSDGREDGRLWCATTYDYKTDEKWGFCETEEDAAKRRQMQEAEMIYQAGMKILNGSNRKSQKREAYRYLQKAAGMNHTKALERVSYALLFGDYLTQNIQAAKEMFEKLTEEGSPKGQTGLGFLYASGLGVNSSQAKALVYYTFGALGGNLIAHMILGYRYWAGIGVLQSCESALTHYRLVANHVASDISLTGGSVVQRIRLPDEVENPGMNSGMLEEDLIQYYQFLAEKGDVQAQVGLGQLHLHGGRGVEQNHQRAFDYFNLAANAGNSHAMAFLGKMYSEGSDIVPQSNETALHYFKKAADMGNPVGQSGLGMAYLYGRGVQVNYDLALKYFQKAAEQGWVDGQLQLGSMYYNGIGVKRDYKQALKYFNLASQGGHILAFYNLAQMHASGTGVMRSCHTAVELFKNVCERGRWSERLMTAYNSYKDEDYNAAVVQYLLLAEQGYEVAQSNAAFILDQREATIVGENETYPRALLHWNRAASQGYTVARIKLGDYHFYGFGTDVDYETAFIHYRLASEQQHSAQAMFNLGYMHEKGLGIKQDIHLAKRFYDMAAEASPDAQVPVFLALCKLGVVYFLQYIREANIRDLFTQLDMDQLLGPEWDLYLMTIIALLLGTVIAYRQRQHQDIPVPRPPGPRPAPPQQEGPPEQQPPQ
uniprot
proteins
function
FUNCTION: Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:24453213, PubMed:25066055). Enhances SYVN1 stability (PubMed:24453213). Plays a role in LPL maturation and secretion (PubMed:25066055). Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells (PubMed:20170518, PubMed:24453213). May play a role in Notch signaling (PubMed:20170518). {ECO:0000269|PubMed:20170518, ECO:0000269|PubMed:24453213, ECO:0000269|PubMed:25066055}.
uniprot
proteins
mass_dalton
88340
uniprot
proteins
mutagenesis
MUTAGEN 512..513; /note="GG->KK: Abolishes homodimerization."; /evidence="ECO:0000269|PubMed:27064360"; MUTAGEN 515..516; /note="IL->AA: Abolishes homodimerization; when associated with A-519."; /evidence="ECO:0000269|PubMed:27064360"; MUTAGEN 519; /note="Y->A: Abolishes homodimerization; when associated with 515-A-A-516."; /evidence="ECO:0000269|PubMed:27064360"; MUTAGEN 521; /note="L->A: Abolishes homodimerization."; /evidence="ECO:0000269|PubMed:27064360
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:25066055}.
uniprot
proteins
protein_family
Sel-1 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20170518
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24453213
uniprot
proteins
pubmed
25066055
uniprot
proteins
pubmed
27064360
uniprot
proteins
pubmed
9858735
uniprot
proteins
sequence_length
790
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9UBV2}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9UBV2}.
uniprot
proteins
transmembrane_region
TRANSMEM 735..755; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins