PNRC2
entrez
55629
canonical
uniprot
Q9NPJ4
canonical
ensembl
ENSG00000189266
resolver
ensp
ENSP00000334840
resolver
ensp
ENSP00000497590
resolver
genesymbol
PNRC2
resolver
hgnc
HGNC:23158
resolver
uniprot
B4DU72
resolver
uniprot_entry
PNRC2_HUMAN
resolver
uniprot_sec
B4DU72
resolver
amino_acid_sequence
MGGGERYNIPAPQSRNVSKNQQQLNRQKTKEQNSQMKIVHKKKERGHGYNSSAAAWQAMQNGGKNKNFPNNQSWNSSLSGPRLLFKSQANQNYAGAKFSEPPSPSVLPKPPSHWVPVSFNPSDKEIMTFQLKTLLKVQV
uniprot
proteins
function
FUNCTION: Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (PubMed:19150429). May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (PubMed:19150429). Required for UPF1/RENT1 localization to the P-body (PubMed:19150429). Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5' UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Also acts as a nuclear receptor coactivator (PubMed:11574675). May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity). {ECO:0000250|UniProtKB:Q9CR73, ECO:0000269|PubMed:11574675, ECO:0000269|PubMed:19150429, ECO:0000269|PubMed:25775514}.
uniprot
proteins
mass_dalton
15591
uniprot
proteins
mutagenesis
MUTAGEN 101; /note="P->A: Abolishes the interaction with the nuclear receptors but not decapping enzyme; when associated with A-104."; /evidence="ECO:0000269|PubMed:11574675, ECO:0000269|PubMed:25775514"; MUTAGEN 104; /note="P->A: Abolishes the interaction with the nuclear receptors but not decapping enzyme; when associated with A-101."; /evidence="ECO:0000269|PubMed:11574675, ECO:0000269|PubMed:25775514"; MUTAGEN 108; /note="P->A: Abolishes the interaction with DCP1A."; /evidence="ECO:0000269|PubMed:25775514"; MUTAGEN 114; /note="W->A: Abolishes the interaction with DCP1A."; /evidence="ECO:0000269|PubMed:25775514
uniprot
proteins
protein_family
PNRC family
uniprot
proteins
protein_family
PNRC2 subfamily
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
11574675
uniprot
proteins
pubmed
14651967
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19150429
uniprot
proteins
pubmed
25775514
uniprot
proteins
sequence_length
139
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19150429}. Cytoplasm, P-body {ECO:0000269|PubMed:19150429}.
uniprot
proteins