ALDH1L2
entrez
160428
canonical
uniprot
Q3SY69
canonical
ensembl
ENSG00000136010
resolver
ensp
ENSP00000258494
resolver
ensp
ENSP00000776797
resolver
ensp
ENSP00000785166
resolver
genesymbol
ALDH1L2
resolver
hgnc
HGNC:26777
resolver
uniprot
B4DTU7
resolver
uniprot
Q3SY68
resolver
uniprot
Q68D62
resolver
uniprot
Q6AI55
resolver
uniprot
Q8N922
resolver
uniprot_entry
AL1L2_HUMAN
resolver
uniprot_entry
B4DTU7_HUMAN
resolver
uniprot_sec
Q3SY68
resolver
uniprot_sec
Q68D62
resolver
uniprot_sec
Q6AI55
resolver
uniprot_sec
Q8N922
resolver
amino_acid_sequence
MLRRGSQALRRFSTGRVYFKNKLKLALIGQSLFGQEVYSHLRKEGHRVVGVFTVPDKDGKADPLALAAEKDGTPVFKLPKWRVKGKTIKEVAEAYRSVGAELNVLPFCTQFIPMDIIDSPKHGSIIYHPSILPRHRGASAINWTLIMGDKKAGFSVFWADDGLDTGPILLQRSCDVEPNDTVDALYNRFLFPEGIKAMVEAVQLIADGKAPRIPQPEEGATYEGIQKKENAEISWDQSAEVLHNWIRGHDKVPGAWTEINGQMVTFYGSTLLNSSVPPGEPLEIKGAKKPGLVTKNGLVLFGNDGKALTVRNLQFEDGKMIPASQYFSTGETSVVELTAEEVKVAETIKVIWAGILSNVPIIEDSTDFFKSGASSMDVARLVEEIRQKCGGLQLQNEDVYMATKFEGFIQKVVRKLRGEDQEVELVVDYISKEVNEIMVKMPYQCFINGQFTDADDGKTYDTINPTDGSTICKVSYASLADVDKAVAAAKDAFENGEWGRMNARERGRLMYRLADLLEENQEELATIEALDSGAVYTLALKTHIGMSVQTFRYFAGWCDKIQGSTIPINQARPNRNLTFTKKEPLGVCAIIIPWNYPLMMLAWKSAACLAAGNTLVLKPAQVTPLTALKFAELSVKAGFPKGVINIIPGSGGIAGQRLSEHPDIRKLGFTGSTPIGKQIMKSCAVSNLKKVSLELGGKSPLIIFNDCELDKAVRMGMGAVFFNKGENCIAAGRLFVEESIHDEFVTRVVEEIKKMKIGDPLDRSTDHGPQNHKAHLEKLLQYCETGVKEGATLVYGGRQVQRPGFFMEPTVFTDVEDYMYLAKEESFGPIMVISKFQNGDIDGVLQRANSTEYGLASGVFTRDINKAMYVSEKLEAGTVFINTYNKTDVAAPFGGVKQSGFGKDLGEEALNEYLKTKTVTLEY
uniprot
proteins
ec_number
1.5.1.6
uniprot
proteins
function
FUNCTION: Mitochondrial 10-formyltetrahydrofolate dehydrogenase that catalyzes the NADP(+)-dependent conversion of 10-formyltetrahydrofolate to tetrahydrofolate and carbon dioxide. {ECO:0000269|PubMed:21238436, ECO:0000269|PubMed:38193334}.
uniprot
proteins
mass_dalton
101746
uniprot
proteins
mutagenesis
MUTAGEN 374; /note="S->A: No effect on phosphopantetheinylation."; /evidence="ECO:0000269|PubMed:21238436"; MUTAGEN 375; /note="S->A: Loss of phosphopantetheinylation."; /evidence="ECO:0000269|PubMed:21238436
uniprot
proteins
post_translational_modification
PTM: Phosphopantetheinylation at Ser-375 by AASDHPPT is required for the formyltetrahydrofolate dehydrogenase activity. {ECO:0000269|PubMed:21238436}.
uniprot
proteins
protein_family
ALDH1L subfamily
uniprot
proteins
protein_family
GART family; Aldehyde dehydrogenase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20498374
uniprot
proteins
pubmed
21238436
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
38193334
uniprot
proteins
sequence_length
923
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:20498374}.
uniprot
proteins