Fblim1
entrez
74202
canonical
uniprot
Q71FD7
canonical
ensembl
ENSMUSG00000006219
resolver
ensp
ENSMUSP00000006381
resolver
ensp
ENSMUSP00000101410
resolver
ensp
ENSMUSP00000101411
resolver
ensp
ENSMUSP00000292326
resolver
ensp
ENSMUSP00000292327
resolver
ensp
ENSMUSP00000292335
resolver
ensp
ENSMUSP00000292337
resolver
ensp
ENSMUSP00000292339
resolver
ensp
ENSMUSP00000340242
resolver
ensp
ENSMUSP00000340252
resolver
enst
ENSMUST00000006381
resolver
enst
ENSMUST00000105784
resolver
enst
ENSMUST00000105785
resolver
genesymbol
Fblim1
resolver
genesymbol_syn
Cal
resolver
uniprot
Q3TDK3
resolver
uniprot
Q99J35
resolver
uniprot_entry
FBLI1_MOUSE
resolver
uniprot_sec
Q3TDK3
resolver
uniprot_sec
Q99J35
resolver
amino_acid_sequence
MASKPEKRVASSVFITLAPPRRDVAVSEEVGQAACEARRARPWEMLPTKTPGAAVGRSPKTWTPSGKTNASLSGVTPQLSNGGCSLPPPSLNEEDLDLPPPPPPPSAYLPLPEEEPPVLPGKSLISDLEQLHLPPPPPPPPPQAPSKGSSVHPPPGHAIPSEEELPPPPEEPVTLPEREVSTDVCGFCHKPVSPRELAVEAMKRQYHAQCFTCRTCRRQLAGQRFYQKDGRPLCEPCYQDTLEKCGKCGEVVQEHVIRALGKAFHPPCFTCVTCARCISDESFALDSQNQVYCVADFYRKFAPVCSICENPIIPRDGKDAFKIECMGRNFHENCYRCEDCSVLLSVEPTDQGCYPLNDHLFCKPCHLKRSAAGCC
uniprot
proteins
function
FUNCTION: Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
41026
uniprot
proteins
pubmed
14757752
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
375
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q8WUP2}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:Q8WUP2}. Note=Associated with actin stress fiber at cell-ECM focal adhesion sites. Recruited and localized at actin stress fibers and clustered at cell-EMC adhesion sites through interaction with FERMT2. {ECO:0000250|UniProtKB:Q8WUP2}.
uniprot
proteins