Gls2
entrez
216456
canonical
uniprot
Q571F8
canonical
ensembl
ENSMUSG00000044005
resolver
ensp
ENSMUSP00000047376
resolver
enst
ENSMUST00000044776
resolver
genesymbol
Gls2
resolver
genesymbol_syn
Kiaa4146
resolver
uniprot
B2RUF2
resolver
uniprot
Q3TMJ6
resolver
uniprot_entry
GLSL_MOUSE
resolver
uniprot_sec
B2RUF2
resolver
uniprot_sec
Q3TMJ6
resolver
activity_regulation
ACTIVITY REGULATION: Enzyme activity is not stimulated by phosphate. Phosphate increases kcat, but decreases substrate affinity, resulting in unchanged enzyme activity. {ECO:0000269|PubMed:22228304}.
uniprot
proteins
amino_acid_sequence
MRSMRALQNALSRAGSHGRRGGWGHPSRGPLLGRGVRYYLGEAAAQGRGTPHSHQPQHSDHDASHSGMLPRLGDLLFYTIAEGQERIPIHKFTTALKATGLQTSDPRLQDCMSKMQRMVQESSSGGLLDRELFQKCVSSNIVLLTQAFRKKFVIPDFEEFTGHVDRIFEDAKEPTGGKVAAYIPHLAKSNPDLWGVSLCTVDGQRHSVGHTKIPFCLQSCVKPLTYAISVSTLGTDYVHKFVGKEPSGLRYNKLSLNEEGIPHNPMVNAGAIVVSSLIKMDCNKAEKFDFVLQYLNKMAGNEFMGFSNATFQSEKETGDRNYAIGYYLKEKKCFPKGVDMMAALDLYFQLCSVEVTCESGSVMAATLANGGICPITGESVLSAEAVRNTLSLMHSCGMYDFSGQFAFHVGLPAKSAVSGAILLVVPNVMGMMCLSPPLDKLGNSQRGINFCQKLVSLFNFHNYDNLRHCARKLDPRREGGEVRNKTVVNLLFAAYSGDVSALRRFALSAMDMEQKDYDSRTALHVAAAEGHIEVVKFLIEACKVNPFVKDRWGNIPLDDAVQFNHLEVVKLLQDYHDSYLLSETQAEAAAETLSKENLESMV
uniprot
proteins
ec_number
3.5.1.2
uniprot
proteins
function
FUNCTION: Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation. {ECO:0000250|UniProtKB:Q9UI32}.
uniprot
proteins
mass_dalton
66366
uniprot
proteins
protein_family
Glutaminase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22228304
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
23935106
uniprot
proteins
sequence_length
602
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9UI32}.
uniprot
proteins