Ccr1
entrez
12768
canonical
uniprot
P51675
canonical
ensembl
ENSMUSG00000025804
resolver
ensp
ENSMUSP00000026911
resolver
enst
ENSMUST00000026911
resolver
genesymbol
Ccr1
resolver
genesymbol_syn
Cmkbr1
resolver
uniprot
Q6ZWR7
resolver
uniprot
Q8BMH9
resolver
uniprot
Q8BVW4
resolver
uniprot
Q91VP9
resolver
uniprot_entry
CCR1_MOUSE
resolver
uniprot_entry
Q8BMH9_MOUSE
resolver
uniprot_entry
Q8BVW4_MOUSE
resolver
uniprot_sec
Q6ZWR7
resolver
uniprot_sec
Q91VP9
resolver
amino_acid_sequence
MEISDFTEAYPTTTEFDYGDSTPCQKTAVRAFGAGLLPPLYSLVFIIGVVGNVLVILVLMQHRRLQSMTSIYLFNLAVSDLVFLFTLPFWIDYKLKDDWIFGDAMCKLLSGFYYLGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGIITSIITWALAILASMPALYFFKAQWEFTHRTCSPHFPYKSLKQWKRFQALKLNLLGLILPLLVMIICYAGIIRILLRRPSEKKVKAVRLIFAITLLFFLLWTPYNLSVFVSAFQDVLFTNQCEQSKQLDLAMQVTEVIAYTHCCVNPIIYVFVGERFWKYLRQLFQRHVAIPLAKWLPFLSVDQLERTSSISPSTGEHELSAGF
uniprot
proteins
function
FUNCTION: Chemokine receptor that plays a crucial role in regulating immune cell migration, inflammation, and immune responses (PubMed:9166425). Contributes to the inflammatory response by recruiting immune cells, such as monocytes, macrophages, T-cells, and dendritic cells, to sites of inflammation for the clearance of pathogens and the resolution of tissue damage. When activated by its ligands including CCL3, CCL5-9, CCL13-16 and CCL23, triggers a signaling cascade within immune cells, leading to their migration towards the source of the chemokine (By similarity). For example, mediates neutrophil migration after activation by CCL3 leading to the sequential release of TNF and leukotriene B4 (PubMed:15831559). Also mediates monocyte migration upon CXCL4 binding (By similarity). Activation by CCL5 results in neuroinflammation through the ERK1/2 signaling pathway (PubMed:31898284). {ECO:0000250|UniProtKB:P32246, ECO:0000269|PubMed:15831559, ECO:0000269|PubMed:31898284, ECO:0000269|PubMed:9166425}.
uniprot
proteins
mass_dalton
40895
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15831559
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
31898284
uniprot
proteins
pubmed
7542241
uniprot
proteins
pubmed
7594543
uniprot
proteins
pubmed
9166425
uniprot
proteins
sequence_length
355
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P32246}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P32246}.
uniprot
proteins
transmembrane_region
TRANSMEM 35..60; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 65..91; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 108..129; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 147..171; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 198..223; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 240..264; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 282..305; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins