Alas1
entrez
65155
canonical
uniprot
P13195
canonical
ensembl
ENSRNOG00000056596
resolver
ensembl
ENSRNOG00055012998
resolver
ensembl
ENSRNOG00060030062
resolver
ensembl
ENSRNOG00065008399
resolver
ensp
ENSRNOP00000074873
resolver
ensp
ENSRNOP00055018088
resolver
ensp
ENSRNOP00060043540
resolver
ensp
ENSRNOP00065009856
resolver
enst
ENSRNOT00000086232
resolver
enst
ENSRNOT00055022282
resolver
enst
ENSRNOT00060052319
resolver
enst
ENSRNOT00065013325
resolver
genesymbol
Alas1
resolver
uniprot
Q6P782
resolver
uniprot_entry
HEM1_RAT
resolver
uniprot_sec
Q6P782
resolver
amino_acid_sequence
METVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMEVGAKPAPRTVSTSAAQCQQVKETPPANEKEKTAKAAVQQAPDESQMAQTPDGTQLPPGHPSPSTSQSSGSKCPFLAAQLSQTGSSVFRKASLELQEDVQEMHAVRKEVAQSPVLPSLVNAKRDGEGPSPLLKNFQDIMRKQRPERVSHLLQDNLPKSVSTFQYDHFFEKKIDEKKNDHTYRVFKTVNRRAQIFPMADDYTDSLITKKQVSVWCSNDYLGMSRHPRVCGAVIETVKQHGAGAGGTRNISGTSKFHVELEQELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVNHLRELLQRSDPSVPKIVAFETVHSMDGAVCPLEELCDVAHEFGAITFVDEVHAVGLYGASGGGIGDRDGVMPKMDIISGTLGKAFGCVGGYIASTSLLIDTVRSYAAGFIFTTSLPPMLLAGALESVRILKSNEGRALRRQHQRNVKLMRQMLMDAGLPVIHCPSHIIPVRVADAAKNTEICDELMTRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNFFLEKLLLTWKRVGLELKPHSSAECNFCRRPLHFEVMSEREKAYFSGMSKMVSAQA
uniprot
proteins
ec_number
2.3.1.37
uniprot
proteins
function
FUNCTION: Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products. {ECO:0000250|UniProtKB:P13196}.
uniprot
proteins
mass_dalton
71021
uniprot
proteins
pathway_participation
PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.
uniprot
proteins
post_translational_modification
PTM: In normoxia, is hydroxylated at Pro-578, promoting interaction with VHL, initiating ubiquitination and subsequent degradation via the proteasome. {ECO:0000250|UniProtKB:P13196}.; PTM: Ubiquitinated; in normoxia following hydroxylation and interaction with VHL, leading to its subsequent degradation via the proteasome. {ECO:0000250|UniProtKB:P13196}.
uniprot
proteins
protein_family
Class-II pyridoxal-phosphate-dependent aminotransferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
3182776
uniprot
proteins
pubmed
3356687
uniprot
proteins
sequence_length
642
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P22557}; Peripheral membrane protein {ECO:0000250|UniProtKB:P22557}. Note=Localizes to the matrix side of the mitochondrion inner membrane. {ECO:0000250|UniProtKB:P22557}.
uniprot
proteins