Eif2s3
entrez
299027
canonical
uniprot
P81795
canonical
ensembl
ENSRNOG00000060793
resolver
ensembl
ENSRNOG00055030528
resolver
ensembl
ENSRNOG00060015583
resolver
ensembl
ENSRNOG00065010058
resolver
ensp
ENSRNOP00000070817
resolver
ensp
ENSRNOP00055043820
resolver
ensp
ENSRNOP00060021413
resolver
ensp
ENSRNOP00065012283
resolver
enst
ENSRNOT00000092019
resolver
enst
ENSRNOT00055053020
resolver
enst
ENSRNOT00060026737
resolver
enst
ENSRNOT00065016222
resolver
genesymbol
Eif2s3
resolver
genesymbol_syn
Eif2g
resolver
genesymbol_syn
Eif2s3x
resolver
uniprot
B0BN96
resolver
uniprot
B2RYH8
resolver
uniprot
Q5BJX8
resolver
uniprot_entry
IF2G_RAT
resolver
uniprot_sec
B0BN96
resolver
uniprot_sec
B2RYH8
resolver
uniprot_sec
Q5BJX8
resolver
amino_acid_sequence
MAGGEAGVTLGQPHLSRQDLATLDVTKLTPLSHEVISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDPSCPRPECYRSCGSSTPDEFPTDIPGTKGNFKLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPPRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIGWGQIRRGVTIKPTVDDD
uniprot
proteins
ec_number
3.6.5.3
uniprot
proteins
function
FUNCTION: Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage (By similarity). {ECO:0000250|UniProtKB:P05198, ECO:0000250|UniProtKB:Q9Z0N1}.
uniprot
proteins
mass_dalton
51079
uniprot
proteins
protein_family
Classic translation factor GTPase family
uniprot
proteins
protein_family
EIF2G subfamily
uniprot
proteins
protein_family
TRAFAC class translation factor GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
25548914
uniprot
proteins
pubmed
8780732
uniprot
proteins
pubmed
9736774
uniprot
proteins
sequence_length
472
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q09130}.
uniprot
proteins