TMEM170B
entrez
100113407
canonical
uniprot
Q5T4T1
canonical
ensembl
ENSG00000205269
resolver
ensp
ENSP00000368737
resolver
enst
ENST00000379426
resolver
genesymbol
TMEM170B
resolver
hgnc
HGNC:34244
resolver
uniprot_entry
T170B_HUMAN
resolver
amino_acid_sequence
MKAEGGDHSMINLSVQQVLSLWAHGTVLRNLTEMWYWIFLWALFSSLFVHGAAGVLMFVMLQRHRQGRVISVIAVSIGFLASVTGAMITSAAVAGIYRVAGKNMAPLEALVWGVGQTVLTLIISFSRILATL
uniprot
proteins
function
FUNCTION: Negatively regulates the canonical Wnt signaling in breast cancer cells. Exerts an inhibitory effect on breast cancer growth by inhibiting CTNNB1 stabilization and nucleus translocation, which reduces the activity of Wnt targets (PubMed:29367600). {ECO:0000269|PubMed:29367600}.
uniprot
proteins
mass_dalton
14360
uniprot
proteins
protein_family
TMEM170 family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
29367600
uniprot
proteins
sequence_length
132
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29367600}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 38..58; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 69..89; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 105..125; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins