Dsg1a
entrez
13510
canonical
uniprot
Q61495
canonical
ensembl
ENSMUSG00000069441
resolver
ensp
ENSMUSP00000076393
resolver
enst
ENSMUST00000077146
resolver
genesymbol
Dsg1a
resolver
genesymbol_syn
Dsg1
resolver
uniprot
A8WFQ4
resolver
uniprot
Q8CE03
resolver
uniprot_entry
DSG1A_MOUSE
resolver
uniprot_sec
A8WFQ4
resolver
uniprot_sec
Q8CE03
resolver
amino_acid_sequence
MDWHSFRIAALLLTSLVVLEVNSEFQIQVRDHNAKNGTIKWHSIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQPVTYRISGVGIDQPPYGIFIINQKTGEINITSIVDREVTPFFIIYCRALNAQGQDLENPLELRVRVMDINDNPPVFSMTTFLGQIEENSNANTLVMKLNATDADEPNNLNSMIAFKIIRQEPSDSPMFIINRKTGEIRTMNNFLDREQYSQYSLVVRGSDRDGGADGMSAESECSITILDVNDNIPYLEQSSYDITIEENALHSQLVQIRVIDLDEEFSDNWKAIIFFISGNEGNWFEIEMNERTNVGTLKVVKPLDYEAMKNLQLSIGVRNVAEFHQSIISQYRLTATMVTVTVLNVIEGSVFRPGSKTFVVDSRMEANHRVGEFVATDLDTGRASTNVRYEMGNNPENLLVVDSRTGIITLRNRVTMEQYQRLNGEYKGTVLSIDDSLQRTCTGTIVIELSGTGWVTGSESGGSSSGSGDDRDRVTNGYQGTSSTENPQRVTGSWGGSGIDGTRPNTNPFQGDPDETLETPLYGDNVHFGPAGIGLLIMGFLVLGLVPFLLICCDCGGAPGGGAGFEPVPECSDGAIHTWAVEGPQPEPHEGITTICVPQMPPGNANVIEYIDNSGVYTNEYCGREMQDLGGGERTTGFELMDGVKTSAAPEICQEYSGTLRRNSMRECRDGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIGEDLDESFLDTLGPKFKKLADISLGKEIDSYPDSDPSWPPQSTEPMCPQHTEPLGSGHPPISPHFGTTTVISENAYHSGPGVQHPVPIPDPLGYGNVTVRESYTTSGTLKPSVHFHDNQQASNVVVTERVVGPISGADLHGMLEIPDLRGGANVIVTERVIAPGSSLPTSLTIPNPQETSNVVVTERVIQPTSGMIGNLSMTPELSSAHNVIVTERVVSGAGMSEIAGTAGLGGVGGIGSSGLVSTTMGASGTGLNMGGTATIGHMRSSSDHHFSQTVGSASPSMARSRITKYNTVQYSK
uniprot
proteins
function
FUNCTION: A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Mediates the interaction between the desmosome and COP9 signalosome complex (CSN) protein complex (By similarity). As a result of this interaction, promotes keratinocyte differentiation via deneddylation of EGFR resulting in a reduction in EGFR protein stabilization and translocation away from the cell membrane (By similarity). Critical for epidermal integrity and barrier function of the skin (PubMed:30660666). May mediate the inflammatory response in the epidermis (PubMed:34905516). Required for esophageal epithelial barrier integrity and correct intercellular spacing in differentiated esophageal epithelium (By similarity). Required for recovery of epidermal architecture and correct expression of differentiation markers following UVB exposure (By similarity). May also be required for OCLN involvement in tight junctions (PubMed:30660666). {ECO:0000250|UniProtKB:Q02413, ECO:0000250|UniProtKB:Q7TSF1, ECO:0000269|PubMed:30660666, ECO:0000269|PubMed:34905516}.
uniprot
proteins
mass_dalton
114597
uniprot
proteins
post_translational_modification
PTM: (Microbial infection) Proteolytically processed by Staphylococcus aureus serine protease eta. {ECO:0000269|PubMed:12093888}.
uniprot
proteins
pubmed
11994138
uniprot
proteins
pubmed
12093888
uniprot
proteins
pubmed
12631242
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
24220297
uniprot
proteins
pubmed
30660666
uniprot
proteins
pubmed
34905516
uniprot
proteins
pubmed
7959727
uniprot
proteins
sequence_length
1057
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q7TSF1}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q7TSF1}. Cell junction, desmosome {ECO:0000250|UniProtKB:Q7TSF1}. Cytoplasm {ECO:0000250|UniProtKB:Q02413}. Nucleus {ECO:0000250|UniProtKB:Q02413}.
uniprot
proteins
transmembrane_region
TRANSMEM 565..585; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins