IGFBP2
entrez
3485
canonical
uniprot
P18065
canonical
ensembl
ENSG00000115457
resolver
ensp
ENSP00000233809
resolver
ensp
ENSP00000389646
resolver
enst
ENST00000233809
resolver
enst
ENST00000456764
resolver
genesymbol
IGFBP2
resolver
genesymbol_syn
BP2
resolver
genesymbol_syn
IBP2
resolver
hgnc
HGNC:5471
resolver
uniprot
C9JMY1
resolver
uniprot
Q14619
resolver
uniprot
Q9UCL3
resolver
uniprot_entry
C9JMY1_HUMAN
resolver
uniprot_entry
IBP2_HUMAN
resolver
uniprot_sec
Q14619
resolver
uniprot_sec
Q9UCL3
resolver
amino_acid_sequence
MLPRVGCPALPLPPPPLLPLLLLLLGASGGGGGARAEVLFRCPPCTPERLAACGPPPVAPPAAVAAVAGGARMPCAELVREPGCGCCSVCARLEGEACGVYTPRCGQGLRCYPHPGSELPLQALVMGEGTCEKRRDAEYGASPEQVADNGDDHSEGGLVENHVDSTMNMLGGGGSAGRKPLKSGMKELAVFREKVTEQHRQMGKGGKHHLGLEEPKKLRPPPARTPCQQELDQVLERISTMRLPDERGPLEHLYSLHIPNCDKHGLYNLKQCKMSLNGQRGECWCVNPNTGKLIQGAPTIRGDPECHLFYNEQQEARGVHTQRMQ
uniprot
proteins
function
FUNCTION: Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:18563800, PubMed:38796567). Functions coordinately with receptor protein tyrosine phosphatase beta/PTPRB and the IGF1 receptor to regulate IGF1-mediated signaling by stimulating the phosphorylation of PTEN leading to its inactivation and AKT1 activation (PubMed:22869525). Plays a positive role in cell migration via interaction with integrin alpha5/ITGA5 through an RGD motif (PubMed:16569642). Additionally, interaction with ITGA5/ITGB1 enhances the adhesion of endothelial progenitor cells to endothelial cells (PubMed:26076738). Upon mitochondrial damage, facilitates apoptosis with ITGA5 of podocytes, and then activates the phosphorylation of focal adhesion kinase (FAK)-mediated mitochondrial injury (PubMed:38796567). {ECO:0000269|PubMed:16569642, ECO:0000269|PubMed:18563800, ECO:0000269|PubMed:19081843, ECO:0000269|PubMed:22869525, ECO:0000269|PubMed:26076738, ECO:0000269|PubMed:38796567}.
uniprot
proteins
mass_dalton
34814
uniprot
proteins
mutagenesis
MUTAGEN 216..219; /note="KKLR->NNLA: Does not disrupt growth-inhibiting activity."; /evidence="ECO:0000269|PubMed:19081843"; MUTAGEN 303; /note="D->E: Does not disrupt growth-inhibiting activity. Loss of endothelial progenitor cells-endothelial adhesion activity."; /evidence="ECO:0000269|PubMed:19081843, ECO:0000269|PubMed:26076738
uniprot
proteins
post_translational_modification
PTM: Cleaved by MMP9 leading to release of free IGF2 from IGFBP2-IGF2 complex, which contributes to enhance the motility and the growth of astrocytes. {ECO:0000269|PubMed:18563800}.; PTM: O-glycosylated. {ECO:0000269|PubMed:1726837}.
uniprot
proteins
pubmed
1376411
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16569642
uniprot
proteins
pubmed
1697583
uniprot
proteins
pubmed
17020769
uniprot
proteins
pubmed
1710112
uniprot
proteins
pubmed
1712312
uniprot
proteins
pubmed
1726837
uniprot
proteins
pubmed
18563800
uniprot
proteins
pubmed
19081843
uniprot
proteins
pubmed
22869525
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2479552
uniprot
proteins
pubmed
26076738
uniprot
proteins
pubmed
34035374
uniprot
proteins
pubmed
38796567
uniprot
proteins
sequence_length
325
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22869525, ECO:0000269|PubMed:34035374, ECO:0000269|PubMed:38796567}.
uniprot
proteins