Epx
entrez
13861
canonical
uniprot
P49290
canonical
ensembl
ENSMUSG00000052234
resolver
ensp
ENSMUSP00000050497
resolver
enst
ENSMUST00000049768
resolver
genesymbol
Epx
resolver
genesymbol_syn
Eper
resolver
uniprot
Q3V1J3
resolver
uniprot
Q5SW51
resolver
uniprot
Q61798
resolver
uniprot_entry
PERE_MOUSE
resolver
uniprot_entry
Q3V1J3_MOUSE
resolver
uniprot_sec
Q5SW51
resolver
uniprot_sec
Q61798
resolver
amino_acid_sequence
MMQQLLALVGALATLILTQHAEGTAPASPSPVEISVLRDCIAEAKLLVDTAYNHTQKSIMQRLRSGSASPMDLLAYFKQPVAATRRVVQAADYMHVALGLLEERLQPRGSRPFNATDVLTEPQLRLLSQASGCALQDQAERCSNKYRTITGRCNNKKHPWLGASNQALARWLPAEYEDHRSLPFGWTPGKRRNGFLLPLVRDVSNQIVRFPSKKLTSDRGRALMFMQWGQFIDHDLDFSPESPARVAFSMGVDCEKTCAQLPPCFPIKIPRNDPRIKNQRDCIPFFRSAPACPQNRNKVRNQINALTSFVDASMVYGSEVTLALRLRNRTNFLGLLATNQRFQDNGRALLPFDNLHEDPCLLTNRSARIPCFLAGDTRSSETPKLTALHTLFVREHNRLAAELRRLNPHWSGDKLYNEARKIVGAMVQIITYRDFLPLVLGRARIRRTLGPYRGYCSNVDPRVANVFTLAFRFGHTMLQPFMFRLDSQYRASAPNSHVPLSSVFFASWRIIHEGGIDPILRGLMATPAKLNRQDSMLVDELRDKLFQQVRRIGLDLAALNMQRSRDHGLPGYNAWRRFCGLSQPRNLAQLSRVLKNQDLARKFLRLYKTPDNIDIWVGAIAEPLLPGARVGPLLACLFENQFRRARDGDRFWWQKWGVFTKRQRKALRRISLSRIVCDNTGITTVSRDIFRANIYPQGFVSCSRIPKLNLSAWRGK
uniprot
proteins
ec_number
1.11.1.7
uniprot
proteins
function
FUNCTION: Heme-containing oxidoreductase that catalyzes the oxidation of small anions, such as nitrite, halides (e.g bromide and chloride (at pH 6.5)) and pseudohalides (e.g thiocyanate) by using hydrogen peroxide to generate the corresponding reactive species hypobromite, hypochlorite, hypothiocyanous acid, and nitrogen dioxide. Also oxidizes thiocyanate (SCN(-)) to cyanate (OCN(-)). Functionally involved in inflammatory responses and exhibits antimicrobial activity (By similarity). Can also oxidize amino acid residues on proteins and generate bromination, nitration and carbamoylation post-translational modifications, respectively (PubMed:18694936). Mediates the nitration of tyrosine (3-nitrotyrosine) which is only observed in secondary granule proteins in mature resting eosinophils in the presence of the cosubstrates, hydrogen peroxide and nitrite (PubMed:18694936). Mediates oxidation of tyrosine residues on proteins in eosinophils to form brominating species, 3-bromotyrosine and 3, 5-dibromotyrosine in the presence of hydrogen peroxide and bromide (By similarity). Promotes protein carbamoylation at sites of inflammation during asthma by using thiocyanate and hydrogen peroxide to form cyanate which carbamoylates lysine residues to form homocitrulline (By similarity). {ECO:0000250|UniProtKB:P11678, ECO:0000250|UniProtKB:P80550, ECO:0000269|PubMed:18694936}.
uniprot
proteins
mass_dalton
81380
uniprot
proteins
protein_family
Peroxidase family
uniprot
proteins
protein_family
XPO subfamily
uniprot
proteins
pubmed
18694936
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8773591
uniprot
proteins
sequence_length
716
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic granule {ECO:0000250|UniProtKB:P11678}. Note=Cytoplasmic granules of eosinophils. {ECO:0000250|UniProtKB:P11678}.
uniprot
proteins