PENK
entrez
5179
canonical
uniprot
P01210
canonical
ensembl
ENSG00000181195
resolver
ensp
ENSP00000324248
resolver
ensp
ENSP00000400894
resolver
ensp
ENSP00000631537
resolver
ensp
ENSP00000631538
resolver
ensp
ENSP00000631539
resolver
ensp
ENSP00000631540
resolver
enst
ENST00000314922
resolver
enst
ENST00000451791
resolver
enst
ENST00000961478
resolver
enst
ENST00000961479
resolver
enst
ENST00000961480
resolver
enst
ENST00000961481
resolver
genesymbol
PENK
resolver
hgnc
HGNC:8831
resolver
uniprot
B2RC23
resolver
uniprot
Q6FHC6
resolver
uniprot
Q6FHE6
resolver
uniprot_entry
PENK_HUMAN
resolver
uniprot_sec
B2RC23
resolver
uniprot_sec
Q6FHC6
resolver
uniprot_sec
Q6FHE6
resolver
amino_acid_sequence
MARFLTLCTWLLLLGPGLLATVRAECSQDCATCSYRLVRPADINFLACVMECEGKLPSLKIWETCKELLQLSKPELPQDGTSTLRENSKPEESHLLAKRYGGFMKRYGGFMKKMDELYPMEPEEEANGSEILAKRYGGFMKKDAEEDDSLANSSDLLKELLETGDNRERSHHQDGSDNEEEVSKRYGGFMRGLKRSPQLEDEAKELQKRYGGFMRRVGRPEWWMDYQKRYGGFLKRFAEALPSDEEGESYSKEVPEMEKRYGGFMRF
uniprot
proteins
function
FUNCTION: [Met-enkephalin]: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. {ECO:0000269|PubMed:7057924}.; FUNCTION: [Leu-enkephalin]: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. {ECO:0000269|PubMed:7057924}.; FUNCTION: [Met-enkephalin-Arg-Phe]: Met-enkephalin-Arg-Phe neuropeptide acts as a strong ligand of Mu-type opioid receptor OPRM1. Met-enkephalin-Arg-Phe-binding to OPRM1 in the nucleus accumbens of the brain increases activation of OPRM1, leading to long-term synaptic depression of glutamate release. {ECO:0000250|UniProtKB:P22005}.; FUNCTION: [PENK(114-133)]: Increases glutamate release in the striatum and decreases GABA concentration in the striatum. {ECO:0000250|UniProtKB:P04094}.; FUNCTION: [Neuropeptide BAM22]: Neuropeptide that mediates stress-induced opioid analgesia (By similarity). Also possesses non-opioid action by acting as a ligand for MRGPRX1 receptor to induce itch in a histamine-independent manner (PubMed:11850634). {ECO:0000250|UniProtKB:P04094, ECO:0000269|PubMed:11850634}.; FUNCTION: [Neuropeptide BAM8-22]: Neuropeptide that induces itch in a histamine-independent manner as well as nociceptive sensations (PubMed:11850634, PubMed:28223516). Acts as a ligand for MRGPRX1 receptor in sensory neurons of dorsal root ganglion: MRGPRX1-binding in the peripheral nervous system elicits itch and scratching, while MRGPRX1-binding in the central nervous system dampens chronic pain (PubMed:11850634, PubMed:21593341, PubMed:28223516, PubMed:36302898, PubMed:37591889, PubMed:39725036). {ECO:0000269|PubMed:11850634, ECO:0000269|PubMed:21593341, ECO:0000269|PubMed:28223516, ECO:0000269|PubMed:36302898, ECO:0000269|PubMed:37591889, ECO:0000269|PubMed:39725036}.; FUNCTION: [PENK(237-258)]: Increases glutamate release in the striatum. {ECO:0000250|UniProtKB:P04094}.
uniprot
proteins
mass_dalton
30787
uniprot
proteins
mutagenesis
MUTAGEN 229; /note="R->A: Abolished ability to activate MRGPRX1."; /evidence="ECO:0000269|PubMed:37591889"; MUTAGEN 230; /note="Y->A: Abolished ability to activate MRGPRX1."; /evidence="ECO:0000269|PubMed:37591889
uniprot
proteins
post_translational_modification
PTM: Proenkephalin-A is cleaved by CTSL to generate Met-enkephalin. {ECO:0000250|UniProtKB:P01211}.; PTM: [Met-enkephalin]: Processed and degraded by ACE. {ECO:0000269|PubMed:656131}.; PTM: [Leu-enkephalin]: Processed and degraded by ACE. {ECO:0000269|PubMed:656131}.; PTM: [Met-enkephalin-Arg-Gly-Leu]: Probably cleaved by ACE. {ECO:0000305|PubMed:2982830}.; PTM: [Met-enkephalin-Arg-Phe]: Processed by ACE to generate Met-enkephalin in the nucleus accumbens of the brain. {ECO:0000250|UniProtKB:P04094}.; PTM: The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing. {ECO:0000269|PubMed:9126357}.
uniprot
proteins
protein_family
Opioid neuropeptide precursor family
uniprot
proteins
pubmed
11850634
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21593341
uniprot
proteins
pubmed
28223516
uniprot
proteins
pubmed
2982830
uniprot
proteins
pubmed
36302898
uniprot
proteins
pubmed
37591889
uniprot
proteins
pubmed
39725036
uniprot
proteins
pubmed
6281660
uniprot
proteins
pubmed
656131
uniprot
proteins
pubmed
7057924
uniprot
proteins
pubmed
9126357
uniprot
proteins
sequence_length
267
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen {ECO:0000250|UniProtKB:P01211}. Secreted {ECO:0000250|UniProtKB:P01211}.
uniprot
proteins