SLC39A6
entrez
25800
canonical
uniprot
Q13433
canonical
ensembl
ENSG00000141424
resolver
ensp
ENSP00000269187
resolver
ensp
ENSP00000401139
resolver
genesymbol
SLC39A6
resolver
genesymbol_syn
LIV1
resolver
genesymbol_syn
ZIP6
resolver
hgnc
HGNC:18607
resolver
uniprot
B4DR49
resolver
uniprot
B4E224
resolver
uniprot
Q8IXR3
resolver
uniprot
Q96HP5
resolver
uniprot_entry
S39A6_HUMAN
resolver
uniprot_sec
B4DR49
resolver
uniprot_sec
B4E224
resolver
uniprot_sec
Q8IXR3
resolver
uniprot_sec
Q96HP5
resolver
amino_acid_sequence
MARKLSVILILTFALSVTNPLHELKAAAFPQTTEKISPNWESGINVDLAISTRQYHLQQLFYRYGENNSLSVEGFRKLLQNIGIDKIKRIHIHHDHDHHSDHEHHSDHERHSDHEHHSEHEHHSDHDHHSHHNHAASGKNKRKALCPDHDSDSSGKDPRNSQGKGAHRPEHASGRRNVKDSVSASEVTSTVYNTVSEGTHFLETIETPRPGKLFPKDVSSSTPPSVTSKSRVSRLAGRKTNESVSEPRKGFMYSRNTNENPQECFNASKLLTSHGMGIQVPLNATEFNYLCPAIINQIDARSCLIHTSEKKAEIPPKTYSLQIAWVGGFIAISIISFLSLLGVILVPLMNRVFFKFLLSFLVALAVGTLSGDAFLHLLPHSHASHHHSHSHEEPAMEMKRGPLFSHLSSQNIEESAYFDSTWKGLTALGGLYFMFLVEHVLTLIKQFKDKKKKNQKKPENDDDVEIKKQLSKYESQLSTNEEKVDTDDRTEGYLRADSQEPSHFDSQQPAVLEEEEVMIAHAHPQEVYNEYVPRGCKNKCHSHFHDTLGQSDDLIHHHHDYHHILHHHHHQNHHPHSHSQRYSREELKDAGVATLAWMVIMGDGLHNFSDGLAIGAAFTEGLSSGLSTSVAVFCHELPHELGDFAVLLKAGMTVKQAVLYNALSAMLAYLGMATGIFIGHYAENVSMWIFALTAGLFMYVALVDMVPEMLHNDASDHGCSRWGYFFLQNAGMLLGFGIMLLISIFEHKIVFRINF
uniprot
proteins
function
FUNCTION: Zinc-influx transporter which plays a role in zinc homeostasis and in the induction of epithelial-to-mesenchymal transition (EMT) (PubMed:12839489, PubMed:18272141, PubMed:21422171, PubMed:23919497, PubMed:27274087, PubMed:34394081). When associated with SLC39A10, the heterodimer formed by SLC39A10 and SLC39A6 mediates cellular zinc uptake to trigger cells to undergo epithelial- to-mesenchymal transition (EMT) (PubMed:27274087). The SLC39A10-SLC39A6 heterodimer also controls NCAM1 phosphorylation and its integration into focal adhesion complexes during EMT (By similarity). Zinc influx inactivates GSK3B, enabling unphosphorylated SNAI1 in the nucleus to down-regulate adherence genes such as CDH1, causing loss of cell adherence (PubMed:23919497). In addition, the SLC39A10-SLC39A6 heterodimer plays an essential role in initiating mitosis by importing zinc into cells to initiate a pathway resulting in the onset of mitosis (PubMed:32797246). Participates in the T-cell receptor signaling regulation by mediating cellular zinc uptake into activated lymphocytes (PubMed:21422171, PubMed:30552163, PubMed:34394081). Regulates the zinc influx necessary for proper meiotic progression to metaphase II (MII) that allows the oocyte-to-egg transition (PubMed:25143461). {ECO:0000250|UniProtKB:Q8C145, ECO:0000269|PubMed:12839489, ECO:0000269|PubMed:18272141, ECO:0000269|PubMed:21422171, ECO:0000269|PubMed:23919497, ECO:0000269|PubMed:25143461, ECO:0000269|PubMed:27274087, ECO:0000269|PubMed:30552163, ECO:0000269|PubMed:32797246, ECO:0000269|PubMed:34394081}.
uniprot
proteins
mass_dalton
85047
uniprot
proteins
post_translational_modification
PTM: Cleaved on the N-terminus before locating to the plasma membrane. {ECO:0000269|PubMed:23919497}.; PTM: N-glycosylated. {ECO:0000269|PubMed:12839489, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:23919497}.; PTM: Phosphorylated by ZAP70 in response to TCR stimulation leading to its activation. {ECO:0000269|PubMed:34394081}.
uniprot
proteins
protein_family
ZIP transporter (TC 2.A.5) family
uniprot
proteins
pubmed
12839489
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
18272141
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21422171
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23919497
uniprot
proteins
pubmed
25143461
uniprot
proteins
pubmed
27274087
uniprot
proteins
pubmed
2903103
uniprot
proteins
pubmed
30552163
uniprot
proteins
pubmed
32797246
uniprot
proteins
pubmed
34394081
uniprot
proteins
sequence_length
755
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18272141}; Multi-pass membrane protein {ECO:0000255}. Cell projection, lamellipodium membrane {ECO:0000269|PubMed:12839489}; Multi-pass membrane protein {ECO:0000269|PubMed:12839489}. Membrane raft {ECO:0000269|PubMed:34394081}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q4V887}. Note=Localizes to lipid rafts in T cells and is recruited into the immunological synapse in response to TCR stimulation (PubMed:34394081). In the choroid plexus is limited to the apical membrane in epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q4V887, ECO:0000269|PubMed:34394081}.
uniprot
proteins
transmembrane_region
TRANSMEM 326..346; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 356..376; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 424..444; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 658..678; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 687..707; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 725..745; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins