Thop1
entrez
50492
canonical
uniprot
Q8C1A5
canonical
ensembl
ENSMUSG00000004929
resolver
ensp
ENSMUSP00000005057
resolver
enst
ENSMUST00000005057
resolver
genesymbol
Thop1
resolver
uniprot
A0A0R4IZY0
resolver
uniprot
Q8K0J9
resolver
uniprot
Q8K2D4
resolver
uniprot
Q9EPX1
resolver
uniprot_entry
A0A0R4IZY0_MOUSE
resolver
uniprot_entry
THOP1_MOUSE
resolver
uniprot_sec
Q8K0J9
resolver
uniprot_sec
Q8K2D4
resolver
uniprot_sec
Q9EPX1
resolver
amino_acid_sequence
MKPPAACAGDVVDAASPASTVNHLRWDLSAQQIRALTTQLIEQTKCVYDRVGAQNFEDVSYESTLKALADVEVTYTVQRNILDFPQHVSPCKDIRAASTEADKKLSEFDVEMSMRQDVYQRVVWLQEKTPKNSLKPEAARYLERLIKLGRRNGLHLPQDTQEKIKNIKKRLSLLCIDFNKNLNEDTTFLPFTREELGGLPEDFLSSLEKAEDGKLKVTLKYPHYFPLLKKCHVPETRRLLEEAFNCRCKEENCAILKELVSLRAQKSSLLGFHTHADYVLEMNMAKTSQTVATFLDELAQKLKPLGEQERAVILELKEAECAKRGLPFDGRIHAWDMRYYMNQVEETRYRVDQNLLKEYFPMQVVTRGLLAIYQELLGLTFTLEEGAAAWHEDVRLYSVRDAASGEEIGKFYLDLYPREGKYGHAACFGLQPGCLRQDGSRQLAVAAMVANFTKPTPDAPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWEKEPLMRMSQHYRTGSEAPQDLLEKLIKSRQANAGLFNLRQIVLAKVDQVLHTQTDADPAEEYARLCQEILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGVLSPKVGMDYRTSILRPGGSEDASAMLKQFLGRDPKQDAFLLSKGLQVEGSEAPAC
uniprot
proteins
ec_number
3.4.24.15
uniprot
proteins
function
FUNCTION: Involved in the metabolism of neuropeptides under 20 amino acid residues long (PubMed:10969067). Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments (By similarity). Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1 (By similarity). {ECO:0000250|UniProtKB:P24155, ECO:0000250|UniProtKB:P52888, ECO:0000269|PubMed:10969067}.
uniprot
proteins
mass_dalton
78026
uniprot
proteins
protein_family
Peptidase M3 family
uniprot
proteins
pubmed
10969067
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
687
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P47788}.
uniprot
proteins