Papss1
entrez
23971
canonical
uniprot
Q60967
canonical
ensembl
ENSMUSG00000028032
resolver
ensp
ENSMUSP00000029666
resolver
ensp
ENSMUSP00000142533
resolver
ensp
ENSMUSP00000142616
resolver
enst
ENSMUST00000029666
resolver
enst
ENSMUST00000199878
resolver
enst
ENSMUST00000200527
resolver
genesymbol
Papss1
resolver
genesymbol_syn
Asapk
resolver
genesymbol_syn
Atpsk1
resolver
genesymbol_syn
Papss
resolver
uniprot
A0A0G2JE36
resolver
uniprot
Q3TUA8
resolver
uniprot
Q3U647
resolver
uniprot
Q6NZM8
resolver
uniprot_entry
A0A0G2JE36_MOUSE
resolver
uniprot_entry
PAPS1_MOUSE
resolver
uniprot_entry
Q3TUA8_MOUSE
resolver
uniprot_entry
Q6NZM8_MOUSE
resolver
uniprot_sec
Q3U647
resolver
amino_acid_sequence
MEIPGSLCKKVKLSNNAQNWGMQRATNVTYQAHHVSRNKRGQVVGTRGGFRGCTVWLTGLSGAGKTTVSMALEEYLVCHGIPCYTLDGDNIRQGLNKNLGFSPEDREENVRRIAEVAKLFADAGLVCITSFISPYTQDRNNARQIHEGASLPFFEVFVDAPLHVCEQRDVKGLYKKARAGEIKGFTGIDSEYEKPEAPELVLKTDSCDVNDCVQQVVELLQERDIVPVDASYEVKELYVPENKLHLAKTDAEALPALKINKVDMQWVQVLAEGWATPLNGFMREREYLQCLHFDCLLDGGVINLSVPIVLTATHEDKERLDGCTAFALVYEGRRVAILRNPEFFEHRKEERCARQWGTTCKNHPYIKMVLEQGDWLIGGDLQVLDRIYWNDGLDQYRLTPTELKQKFKDMNADAVFAFQLRNPVHNGHALLMQDTHKQLLERGYRRPVLLLHPLGGWTKDDDVPLMWRMKQHAAVLEEGILDPETTVVAIFPSPMMYAGPTEVQWHCRARMVAGANFYIVGRDPAGMPHPETGKDLYEPTHGAKVLTMAPGLITLEIVPFRVAAYNKKKKRMDYYDSEHHEDFEFISGTRMRKLAREGQKPPEGFMAPKAWTVLVEYYKSLEKA
uniprot
proteins
ec_number
2.7.1.25
uniprot
proteins
ec_number
2.7.7.4
uniprot
proteins
function
FUNCTION: Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway (PubMed:7493984). Required for normal biosynthesis of sulfated L-selectin ligands in endothelial cells (By similarity). {ECO:0000250|UniProtKB:O43252, ECO:0000269|PubMed:7493984}.
uniprot
proteins
mass_dalton
70794
uniprot
proteins
pathway_participation
PATHWAY: Sulfur metabolism; sulfate assimilation. {ECO:0000269|PubMed:7493984}.
uniprot
proteins
protein_family
APS kinase family; Sulfate adenylyltransferase family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
7493984
uniprot
proteins
sequence_length
624
uniprot
proteins