SLC1A7
entrez
6512
canonical
uniprot
O00341
canonical
ensembl
ENSG00000162383
resolver
ensp
ENSP00000360546
resolver
ensp
ENSP00000360549
resolver
ensp
ENSP00000478639
resolver
ensp
ENSP00000484987
resolver
ensp
ENSP00000497247
resolver
enst
ENST00000611397
resolver
enst
ENST00000620347
resolver
enst
ENST00000649098
resolver
genesymbol
SLC1A7
resolver
genesymbol_syn
EAAT5
resolver
hgnc
HGNC:10945
resolver
uniprot
A0A087WUF9
resolver
uniprot
A0A087X2H3
resolver
uniprot
A0A3B3ISI5
resolver
uniprot
F1T0D3
resolver
uniprot
F1T0D4
resolver
uniprot
G1CT06
resolver
uniprot
Q5VVZ0
resolver
uniprot
Q969Z8
resolver
uniprot
Q9BW45
resolver
uniprot_entry
A0A087WUF9_HUMAN
resolver
uniprot_entry
A0A087X2H3_HUMAN
resolver
uniprot_entry
A0A3B3ISI5_HUMAN
resolver
uniprot_entry
EAA5_HUMAN
resolver
uniprot_entry
F1T0D3_HUMAN
resolver
uniprot_entry
F1T0D4_HUMAN
resolver
uniprot_entry
G1CT06_HUMAN
resolver
uniprot_sec
Q5VVZ0
resolver
uniprot_sec
Q969Z8
resolver
uniprot_sec
Q9BW45
resolver
amino_acid_sequence
MVPHAILARGRDVCRRNGLLILSVLSVIVGCLLGFFLRTRRLSPQEISYFQFPGELLMRMLKMMILPLVVSSLMSGLASLDAKTSSRLGVLTVAYYLWTTFMAVIVGIFMVSIIHPGSAAQKETTEQSGKPIMSSADALLDLIRNMFPANLVEATFKQYRTKTTPVVKSPKVAPEEAPPRRILIYGVQEENGSHVQNFALDLTPPPEVVYKSEPGTSDGMNVLGIVFFSATMGIMLGRMGDSGAPLVSFCQCLNESVMKIVAVAVWYFPFGIVFLIAGKILEMDDPRAVGKKLGFYSVTVVCGLVLHGLFILPLLYFFITKKNPIVFIRGILQALLIALATSSSSATLPITFKCLLENNHIDRRIARFVLPVGATINMDGTALYEAVAAIFIAQVNNYELDFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWALDRFRTMINVLGDALAAGIMAHICRKDFARDTGTEKLLPCETKPVSLQEIVAAQQNGCVKSVAEASELTLGPTCPHHVPVQVEQDEELPAASLNHCTIQISELETNV
uniprot
proteins
function
FUNCTION: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate. Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (PubMed:9108121). Acts primarily as an inhibitory glutamate-gated chloride channel being a major inhibitory presynaptic receptor at mammalian rod bipolar cell axon terminals. Glutamate binding gates a large Cl(-) conductance that mediates inhibition, affecting visual processing in the retina (By similarity). {ECO:0000250|UniProtKB:Q8JZR4, ECO:0000269|PubMed:9108121}.
uniprot
proteins
mass_dalton
60658
uniprot
proteins
protein_family
Dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family
uniprot
proteins
protein_family
SLC1A7 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
9108121
uniprot
proteins
sequence_length
560
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Photoreceptor inner segment membrane {ECO:0000250|UniProtKB:Q8JZR4}; Multi-pass membrane protein {ECO:0000255}. Synaptic cell membrane {ECO:0000250|UniProtKB:Q8JZR4}; Multi-pass membrane protein {ECO:0000255}. Note=Located in both cone and rod photoreceptor terminals and in axon terminals of rod bipolar cells. {ECO:0000250|UniProtKB:Q8JZR4}.
uniprot
proteins
transmembrane_region
TRANSMEM 17..37; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 60..80; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 94..114; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 217..237; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 260..280; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 300..320; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 330..350; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 372..392; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 414..434; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 457..477; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins