Slc12a4
entrez
20498
canonical
uniprot
Q9JIS8
canonical
ensembl
ENSMUSG00000017765
resolver
ensp
ENSMUSP00000034370
resolver
ensp
ENSMUSP00000112130
resolver
enst
ENSMUST00000034370
resolver
enst
ENSMUST00000116429
resolver
genesymbol
Slc12a4
resolver
genesymbol_syn
Kcc1
resolver
uniprot
F8WIJ0
resolver
uniprot
O55069
resolver
uniprot
Q3TPD4
resolver
uniprot
Q3TWZ6
resolver
uniprot
Q3UDQ8
resolver
uniprot
Q9ET57
resolver
uniprot_entry
F8WIJ0_MOUSE
resolver
uniprot_entry
Q3TPD4_MOUSE
resolver
uniprot_entry
Q3TWZ6_MOUSE
resolver
uniprot_entry
Q3UDQ8_MOUSE
resolver
uniprot_entry
S12A4_MOUSE
resolver
uniprot_sec
O55069
resolver
uniprot_sec
Q9ET57
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by WNK3. {ECO:0000250|UniProtKB:Q9UP95}.
uniprot
proteins
amino_acid_sequence
MPHFTVVPVDGPRRGDYDNLEGLSWVDYGERAEREDSDGQGNHRENSPFLCPLDASRGNDYYDRNLALFEEELDIRPKVSSLLGKLVSYTNLTQGAKEHEEAESGEGGRRRAAKAPSMGTLMGVYLPCLQNIFGVILFLRLTWMVGTAGVLQALLIVLICCCCTLLTAISMSAIATNGVVPAGGSYFMISRSLGPEFGGAVGLCFYLGTTFAAAMYILGAIEILLTYIAPPAAIFYPSGTHDMSSATLNNMRVYGTIFLTLMTLVVFVGVKYVNKFASLFLACVIISILSIYAGGIKSIFDPPVFPVCMLGNRTLSRDQFDICAKTVVVDNETVATRLWTFFCHSPNLTADSCDPYFLLNNVTEIPGIPGAAAGVLQENLWSAYLEKGEVVEKHGLPSTDTLGLKESLSLYVVADIATSFTVLVGIFFPSVTGIMAGSNRSGDLRDAQKSIPVGTILAIVTTSLVYFSSVILFGACIEGVVLRDKYGDGVSRNLVVGTLAWPSPWVIVVGSFFSTCGAGLQSLTGAPRLLQAIAKDNIIPFLRVFGHGKANGEPTWALLLTALIAELGILIASLDMVAPILSMFFLMCYLFVNLACAVQTLLRTPNWRPRFKYYHWTLSFLGMSLCLALMFVSSWYYALVAMLIAGMIYKYIEYQGAEKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLLKLDEDLHVKYPRLLTFASQLKAGKGLTIVGSVIQGSFLESYGEAQAAEQTIKNMMDIEKVKGFCQVVVASKVREGLAHLIQSCGLGGMRHNSVVLGWPYGWRQSEDPRAWKTFIDTVRCTTAAHLALLVPKNIAFYPSNHERYLDGHIDVWWIVHDGGMLMLLPFLLRQHKVWKKCRMRIFTVAQMDDNSIQMKKDLAIFLYHLRLEAEVEVVEMHNSDISAYTYERTLMMEQRSQMLRQMRLTKTERDREAQLVKDRHSALRLESLYSDEEEESVAGADKIQMTWTRDKYMAEPWDPSHAPDNFRELVHIKPDQSNVRRMHTAVKLNEVIVTRSHDARLVLLNMPGPPKNSEGDENYMEFLEVLTEGLERVLLVRGGGREVITIYS
uniprot
proteins
function
FUNCTION: Mediates electroneutral potassium-chloride cotransport when activated by cell swelling (PubMed:10564083, PubMed:11551954). May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (Probable). {ECO:0000269|PubMed:10564083, ECO:0000269|PubMed:11551954, ECO:0000305}.
uniprot
proteins
mass_dalton
120624
uniprot
proteins
post_translational_modification
PTM: Phosphorylated, phosphorylation may regulate transporter activity. {ECO:0000250|UniProtKB:Q9UP95}.
uniprot
proteins
protein_family
K/Cl co-transporter subfamily
uniprot
proteins
protein_family
SLC12A transporter family
uniprot
proteins
pubmed
10564083
uniprot
proteins
pubmed
11004507
uniprot
proteins
pubmed
11551954
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9516379
uniprot
proteins
sequence_length
1085
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q28677}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 120..141; /note="Discontinuously helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q9UP95"; TRANSMEM 150..172; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q9UP95"; TRANSMEM 197..225; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q9UP95"; TRANSMEM 249..271; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q9UP95"; TRANSMEM 272..297; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q9UP95"; TRANSMEM 420..440; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q9UP95"; TRANSMEM 451..473; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q9UP95"; TRANSMEM 505..531; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q9UP95"; TRANSMEM 555..575; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q9UP95"; TRANSMEM 576..598; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q9UP95"; TRANSMEM 613..635; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q9UP95"; TRANSMEM 636..651; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:Q9UP95
uniprot
proteins