TFB1M
entrez
51106
canonical
uniprot
Q8WVM0
canonical
ensembl
ENSG00000029639
resolver
ensp
ENSP00000356134
resolver
ensp
ENSP00000673605
resolver
ensp
ENSP00000799510
resolver
enst
ENST00000367166
resolver
genesymbol
TFB1M
resolver
hgnc
HGNC:17037
resolver
uniprot
E5KTM5
resolver
uniprot
Q05DR0
resolver
uniprot
Q9Y384
resolver
uniprot_entry
E5KTM5_HUMAN
resolver
uniprot_entry
TFB1M_HUMAN
resolver
uniprot_sec
Q05DR0
resolver
uniprot_sec
Q9Y384
resolver
amino_acid_sequence
MAASGKLSTCRLPPLPTIREIIKLLRLQAAKQLSQNFLLDLRLTDKIVRKAGNLTNAYVYEVGPGPGGITRSILNADVAELLVVEKDTRFIPGLQMLSDAAPGKLRIVHGDVLTFKVEKAFSESLKRPWEDDPPNVHIIGNLPFSVSTPLIIKWLENISCRDGPFVYGRTQMTLTFQKEVAERLAANTGSKQRSRLSVMAQYLCNVRHIFTIPGQAFVPKPEVDVGVVHFTPLIQPKIEQPFKLVEKVVQNVFQFRRKYCHRGLRMLFPEAQRLESTGRLLELADIDPTLRPRQLSISHFKSLCDVYRKMCDEDPQLFAYNFREELKRRKSKNEEKEEDDAENYRL
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Mitochondrial methyltransferase which uses S-adenosyl methionine to dimethylate two highly conserved adjacent adenosine residues (A1583 and A1584) within the loop of helix 45 at the 3-prime end of 12S rRNA, thereby regulating the assembly or stability of the small subunit of the mitochondrial ribosome (PubMed:12496758, PubMed:25305075, PubMed:31251801). Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity (PubMed:11809803, PubMed:12068295, PubMed:12897151). {ECO:0000269|PubMed:11809803, ECO:0000269|PubMed:12068295, ECO:0000269|PubMed:12496758, ECO:0000269|PubMed:12897151, ECO:0000269|PubMed:25305075, ECO:0000269|PubMed:31251801}.
uniprot
proteins
mass_dalton
39543
uniprot
proteins
mutagenesis
MUTAGEN 65; /note="G->A: Abolishes methyltransferase activity, DNA-binding and SAM-binding. Does not abolish transcription activator function."; /evidence="ECO:0000269|PubMed:12496758, ECO:0000269|PubMed:12897151"; MUTAGEN 85; /note="E->A: Inhibits rRNA (adenine-N6,N6-)-dimethyltransferase activity."; /evidence="ECO:0000269|PubMed:31251801"; MUTAGEN 86; /note="K->A: Inhibits rRNA (adenine-N6,N6-)-dimethyltransferase activity."; /evidence="ECO:0000269|PubMed:31251801"; MUTAGEN 111; /note="D->A: Inhibits rRNA (adenine-N6,N6-)-dimethyltransferase activity."; /evidence="ECO:0000269|PubMed:31251801"; MUTAGEN 112; /note="V->A: Inhibits rRNA (adenine-N6,N6-)-dimethyltransferase activity."; /evidence="ECO:0000269|PubMed:31251801"; MUTAGEN 141; /note="N->A: Does not affect SAM-binding, DNA-binding nor transcription activator function."; /evidence="ECO:0000269|PubMed:12897151"; MUTAGEN 183; /note="R->E: Abolishes the interaction between 12S helix 45 and TFB1M; when associated with E-256 and E-257."; /evidence="ECO:0000269|PubMed:31251801"; MUTAGEN 220; /note="K->A: Abolishes methyltransferase activity. Does not affect SAM-binding, DNA-binding nor transcription activator function."; /evidence="ECO:0000269|PubMed:12496758, ECO:0000269|PubMed:12897151"; MUTAGEN 256; /note="R->E: Abolishes the interaction between 12S helix 45 and TFB1M; when associated with E-183 and E-257."; /evidence="ECO:0000269|PubMed:31251801"; MUTAGEN 257; /note="R->E: Abolishes the interaction between 12S helix 45 and TFB1M; when associated with E-183 and E-256."; /evidence="ECO:0000269|PubMed:31251801
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
KsgA subfamily
uniprot
proteins
protein_family
rRNA adenine N(6)-methyltransferase family
uniprot
proteins
pubmed
10810093
uniprot
proteins
pubmed
11809803
uniprot
proteins
pubmed
12068295
uniprot
proteins
pubmed
12496758
uniprot
proteins
pubmed
12897151
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15110318
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15684387
uniprot
proteins
pubmed
19096125
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
25305075
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
31251801
uniprot
proteins
pubmed
36482135
uniprot
proteins
sequence_length
346
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11809803}.
uniprot
proteins