IFITM2
entrez
10581
canonical
uniprot
Q01629
canonical
ensembl
ENSG00000185201
resolver
ensp
ENSP00000484689
resolver
ensp
ENSP00000505840
resolver
enst
ENST00000616316
resolver
enst
ENST00000680197
resolver
genesymbol
IFITM2
resolver
hgnc
HGNC:5413
resolver
uniprot
Q6FH82
resolver
uniprot
Q96DA8
resolver
uniprot_entry
IFM2_HUMAN
resolver
uniprot_sec
Q6FH82
resolver
uniprot_sec
Q96DA8
resolver
amino_acid_sequence
MNHIVQTFSPVNSGQPPNYEMLKEEQEVAMLGVPHNPAPPMSTVIHIRSETSVPDHVVWSLFNTLFMNTCCLGFIAFAYSVKSRDRKMVGDVTGAQAYASTAKCLNIWALILGIFMTILLIIIPVLVVQAQR
uniprot
proteins
function
FUNCTION: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol (PubMed:26354436, PubMed:33563656). Active against multiple viruses, including influenza A virus, SARS coronaviruses (SARS-CoV and SARS-CoV-2), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1), hepatitis C virus (HCV) and vesicular stomatitis virus (VSV) (PubMed:26354436, PubMed:33239446, PubMed:33270927, PubMed:33563656). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV and SARS-CoV-2 S protein-mediated viral entry and VSV G protein-mediated viral entry (PubMed:33563656). Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. In hepatocytes, IFITM proteins act in a coordinated manner to restrict HCV infection by targeting the endocytosed HCV virion for lysosomal degradation (PubMed:26354436). IFITM2 and IFITM3 display anti-HCV activity that may complement the anti-HCV activity of IFITM1 by inhibiting the late stages of HCV entry, possibly in a coordinated manner by trapping the virion in the endosomal pathway and targeting it for degradation at the lysosome (PubMed:26354436). {ECO:0000269|PubMed:19544527, ECO:0000269|PubMed:20064371, ECO:0000269|PubMed:20534863, ECO:0000269|PubMed:20943977, ECO:0000269|PubMed:21177806, ECO:0000269|PubMed:21253575, ECO:0000269|PubMed:22479637, ECO:0000269|PubMed:26354436, ECO:0000269|PubMed:33239446, ECO:0000269|PubMed:33270927, ECO:0000269|PubMed:33563656}.
uniprot
proteins
mass_dalton
14632
uniprot
proteins
mutagenesis
MUTAGEN 19; /note="Y->F,A: Loss of phosphorylation. Accumulates at the plasma membrane. Increases infection with influenza A virus and SARS-CoV-2. Increases anti-HCV properties."; /evidence="ECO:0000269|PubMed:26354436, ECO:0000269|PubMed:33563656"; MUTAGEN 70..71; /note="CC->AA: No effect on anti-HCV activity. Partial loss of endosomal location."; /evidence="ECO:0000269|PubMed:26354436"; MUTAGEN 104; /note="C->A: Loss of anti-HCV activity. Partial loss of endosomal location."; /evidence="ECO:0000269|PubMed:26354436
uniprot
proteins
post_translational_modification
PTM: Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity. {ECO:0000305|PubMed:26354436}.; PTM: Phosphorylation at Tyr-19 is required for endosomal and lysosomal location. {ECO:0000269|PubMed:26354436}.
uniprot
proteins
protein_family
CD225/Dispanin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
1906403
uniprot
proteins
pubmed
19544527
uniprot
proteins
pubmed
20064371
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20534863
uniprot
proteins
pubmed
20943977
uniprot
proteins
pubmed
21166591
uniprot
proteins
pubmed
21177806
uniprot
proteins
pubmed
21253575
uniprot
proteins
pubmed
22363774
uniprot
proteins
pubmed
22479637
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26354436
uniprot
proteins
pubmed
33239446
uniprot
proteins
pubmed
33270927
uniprot
proteins
pubmed
33563656
uniprot
proteins
sequence_length
132
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:33563656}; Single-pass type II membrane protein {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:26354436}; Single-pass type II membrane protein {ECO:0000305}. Late endosome membrane {ECO:0000269|PubMed:26354436}; Single-pass type II membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 107..127; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins