EPHA1
entrez
2041
canonical
uniprot
P21709
canonical
ensembl
ENSG00000146904
resolver
ensembl
ENSG00000284816
resolver
ensp
ENSP00000275815
resolver
genesymbol
EPHA1
resolver
genesymbol_syn
EPH
resolver
genesymbol_syn
EPHT
resolver
genesymbol_syn
EPHT1
resolver
hgnc
HGNC:3385
resolver
uniprot
A1L3V3
resolver
uniprot
B5A966
resolver
uniprot
B5A967
resolver
uniprot
Q15405
resolver
uniprot_entry
EPHA1_HUMAN
resolver
uniprot_sec
A1L3V3
resolver
uniprot_sec
B5A966
resolver
uniprot_sec
B5A967
resolver
uniprot_sec
Q15405
resolver
amino_acid_sequence
MERRWPLGLGLVLLLCAPLPPGARAKEVTLMDTSKAQGELGWLLDPPKDGWSEQQQILNGTPLYMYQDCPMQGRRDTDHWLRSNWIYRGEEASRVHVELQFTVRDCKSFPGGAGPLGCKETFNLLYMESDQDVGIQLRRPLFQKVTTVAADQSFTIRDLVSGSVKLNVERCSLGRLTRRGLYLAFHNPGACVALVSVRVFYQRCPETLNGLAQFPDTLPGPAGLVEVAGTCLPHARASPRPSGAPRMHCSPDGEWLVPVGRCHCEPGYEEGGSGEACVACPSGSYRMDMDTPHCLTCPQQSTAESEGATICTCESGHYRAPGEGPQVACTGPPSAPRNLSFSASGTQLSLRWEPPADTGGRQDVRYSVRCSQCQGTAQDGGPCQPCGVGVHFSPGARGLTTPAVHVNGLEPYANYTFNVEAQNGVSGLGSSGHASTSVSISMGHAESLSGLSLRLVKKEPRQLELTWAGSRPRSPGANLTYELHVLNQDEERYQMVLEPRVLLTELQPDTTYIVRVRMLTPLGPGPFSPDHEFRTSPPVSRGLTGGEIVAVIFGLLLGAALLLGILVFRSRRAQRQRQQRQRDRATDVDREDKLWLKPYVDLQAYEDPAQGALDFTRELDPAWLMVDTVIGEGEFGEVYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILHLEGVVTKRKPIMIITEFMENGALDAFLREREDQLVPGQLVAMLQGIASGMNYLSNHNYVHRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIPIRWTAPEAIAHRIFTTASDVWSFGIVMWEVLSFGDKPYGEMSNQEVMKSIEDGYRLPPPVDCPAPLYELMKNCWAYDRARRPHFQKLQAHLEQLLANPHSLRTIANFDPRMTLRLPSLSGSDGIPYRTVSEWLESIRMKRYILHFHSAGLDTMECVLELTAEDLTQMGITLPGHQKRILCSIQGFKD
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Also plays a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis. {ECO:0000269|PubMed:17634955, ECO:0000269|PubMed:19118217, ECO:0000269|PubMed:20043122}.
uniprot
proteins
mass_dalton
108127
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Autophosphorylation is stimulated by its ligand EFNA1.; PTM: Ubiquitinated. {ECO:0000269|PubMed:20596523}.
uniprot
proteins
protein_family
Ephrin receptor subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
10369740
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17634955
uniprot
proteins
pubmed
18593464
uniprot
proteins
pubmed
18728013
uniprot
proteins
pubmed
19118217
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
20043122
uniprot
proteins
pubmed
20596523
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
2825356
uniprot
proteins
pubmed
9267020
uniprot
proteins
sequence_length
976
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19118217}; Single-pass type I membrane protein {ECO:0000269|PubMed:19118217}.
uniprot
proteins
transmembrane_region
TRANSMEM 548..568; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins