Havcr2
entrez
363578
canonical
uniprot
P0C0K5
canonical
ensembl
ENSRNOG00000031443
resolver
ensembl
ENSRNOG00055018586
resolver
ensembl
ENSRNOG00060021352
resolver
ensembl
ENSRNOG00065005701
resolver
ensp
ENSRNOP00000048351
resolver
ensp
ENSRNOP00000084467
resolver
ensp
ENSRNOP00000107631
resolver
ensp
ENSRNOP00055025560
resolver
ensp
ENSRNOP00060030538
resolver
ensp
ENSRNOP00065005997
resolver
enst
ENSRNOT00000048485
resolver
enst
ENSRNOT00000108848
resolver
enst
ENSRNOT00000121601
resolver
enst
ENSRNOT00055031627
resolver
enst
ENSRNOT00060037030
resolver
enst
ENSRNOT00065008512
resolver
genesymbol
Havcr2
resolver
genesymbol_syn
Tim3
resolver
genesymbol_syn
Timd3
resolver
uniprot
A0A8I5ZXZ2
resolver
uniprot
A0ABK0LUK6
resolver
uniprot
G3V9I4
resolver
uniprot_entry
A0A8I5ZXZ2_RAT
resolver
uniprot_entry
A0ABK0LUK6_RAT
resolver
uniprot_entry
HAVR2_RAT
resolver
uniprot_sec
G3V9I4
resolver
amino_acid_sequence
MFSWLPFSCALLLLQPLPARSLENAYTAEVGKNAYLPCSYTVPAPGTLVPICWGKGSCPLLQCASVVLRTDETNVTYRKSRRYQLKGNFYKGDMSLTIKNVTLADSGTYCCRIQFPGPMNDEKLELKLSITEPAKVIPAGTAHGDSTTASPRTLTTEGSGSETQTLVTLHDNNGTKISTWADEIKDSGETIRTAVHIGVGVSAGLALALILGVLILKWYSSKKKKLQDLSLITLANSPPGGLVNAGAGRIRSEENIYTIEENIYEMENSNEYYCYVSSQQPS
uniprot
proteins
function
FUNCTION: Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand. Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. In CD8+ cells attenuates TCR-induced signaling, specifically by blocking NF-kappaB and NFAT promoter activities resulting in the loss of IL-2 secretion. The function may implicate its association with LCK proposed to impair phosphorylation of TCR subunits. In contrast, shown to activate TCR-induced signaling in T-cells probably implicating ZAP70, LCP2, LCK and FYN. Expressed on Treg cells can inhibit Th17 cell responses. Receptor for LGALS9. Binding to LGALS9 is believed to result in suppression of T-cell responses; the resulting apoptosis of antigen-specific cells may implicate HAVCR2 phosphorylation and disruption of its association with BAG6. Binding to LGALS9 is proposed to be involved in innate immune response to intracellular pathogens. Expressed on Th1 cells interacts with LGALS9 expressed on Mycobacterium tuberculosis-infected macrophages to stimulate antibactericidal activity including IL-1 beta secretion and to restrict intracellular bacterial growth. However, the function as receptor for LGALS9 has been challenged (By similarity). Also reported to enhance CD8+ T cell responses to an acute infection such as by Listeria monocytogenes. Receptor for phosphatidylserine (PtSer); PtSer-binding is calcium-dependent. May recognize PtSer on apoptotic cells leading to their phagocytosis. Mediates the engulfment of apoptotic cells by dendritic cells. Expressed on T-cells, promotes conjugation but not engulfment of apoptotic cells. Expressed on dendritic cells (DCs) positively regulates innate immune response and in synergy with Toll-like receptors promotes secretion of TNF. In tumor-infiltrating DCs suppresses nucleic acid-mediated innate immune repsonse by interaction with HMGB1 and interfering with nucleic acid-sensing and trafficking of nucleid acids to endosomes. Can enhance mast cell production of Th2 cytokines Il-4, IL-6 and IL-13. Expressed on natural killer (NK) cells and acts as a coreceptor to enhance IFN-gamma production in response to LGALS9. In contrast, shown to suppress NK cell-mediated cytotoxicity. Negatively regulates NK cell function in LPS-induced endotoxic shock. {ECO:0000250|UniProtKB:Q8TDQ0, ECO:0000250|UniProtKB:Q8VIM0}.
uniprot
proteins
mass_dalton
30641
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
protein_family
TIM family
uniprot
proteins
pubmed
15020066
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15913792
uniprot
proteins
sequence_length
282
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell junction {ECO:0000250|UniProtKB:Q8TDQ0}. Note=Localizes to the immunological synapse between CD8+ T-cells and target cells. {ECO:0000250|UniProtKB:Q8TDQ0}.
uniprot
proteins
transmembrane_region
TRANSMEM 195..215; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins