Nek8
entrez
140859
canonical
uniprot
Q91ZR4
canonical
ensembl
ENSMUSG00000017405
resolver
ensp
ENSMUSP00000017549
resolver
ensp
ENSMUSP00000274696
resolver
enst
ENSMUST00000017549
resolver
genesymbol
Nek8
resolver
genesymbol_syn
Jck
resolver
uniprot
Q3U498
resolver
uniprot
Q9D685
resolver
uniprot_entry
NEK8_MOUSE
resolver
uniprot_sec
Q3U498
resolver
uniprot_sec
Q9D685
resolver
amino_acid_sequence
MEKYERIRVVGRGAFGIVHLCLRKADQKLVILKQIPVEQMTKEERQAAQNECQVLKLLNHPNVIEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHLILHRDLKTQNILLDKHRMVVKIGDFGISKILSSKSKAYTVVGTPCYISPELCEGKPYNQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGTFAPISDRYSPELRQLVLSLLSLEPAQRPPLSHIMAQPLCIRALLNIHTDVGSVRMRRAEKSLTPGPPIASGSTGSRATSARCRGVPRGPVRPAIPPPLSSVYAWGGGLSSPLRLPMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGTLLPGAVELPQPQFVSRFLEGQSGVTIKHVACGDLFTACLTDRGIIMTFGSGSNGCLGHGNLTDISQPTIVEALLGYEMVQVACGASHVLALSTDGELFAWGRGDGGRLGLGTRESHNCPQQVPVAPGQEAQRVVCGIDSSMILTSPGRVLACGSNRFNKLGLDHLSLDEEPVPYQQVEEALSFTPLGSAPLDQEPLLCVDLGTAHSAAITASGDCYTFGSNQHGQLGTSSRRVSRAPCRVQGLEGIKMVMVACGDAFTVAVGAEGEVYSWGKGTRGRLGRRDEDAGLPRPVQLDETHPYMVTSVSCCHGNTLLAVRSVTDEPVPP
uniprot
proteins
disease_involvement
DISEASE: Note=A spontaneous mutation in Nek8 is responsible for the juvenile cystic kidney disease (jck) phenotype, which resembles human autosomal recessive polycystic kidney disease. Affected mice have grossly enlarged, spongy-appearing kidney. Focal cysts are evident as early as three days of life. The disease is progressive, the mice are fertile and generally survive to four or more months of age. {ECO:0000269|PubMed:12421721, ECO:0000269|PubMed:8510385}.
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia. Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway. {ECO:0000269|PubMed:18199800}.
uniprot
proteins
mass_dalton
75265
uniprot
proteins
mutagenesis
MUTAGEN 33; /note="K->M: Results in enlarged multinucleated cells."; /evidence="ECO:0000269|PubMed:12421721"; MUTAGEN 336; /note="L->F: Shows a defect in ciliary localization with no apparent effect on ciliation, mitosis or centriole number."; /evidence="ECO:0000269|PubMed:18199800"; MUTAGEN 431; /note="H->Y: Shows a defect in ciliary localization with no apparent effect on ciliation, mitosis or centriole number."; /evidence="ECO:0000269|PubMed:18199800"; MUTAGEN 503; /note="A->P: Shows a defect in ciliary localization with no apparent effect on ciliation, mitosis or centriole number."; /evidence="ECO:0000269|PubMed:18199800
uniprot
proteins
protein_family
NEK Ser/Thr protein kinase family
uniprot
proteins
protein_family
NIMA subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
12421721
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16267153
uniprot
proteins
pubmed
18199800
uniprot
proteins
pubmed
18235101
uniprot
proteins
pubmed
25671767
uniprot
proteins
pubmed
8510385
uniprot
proteins
sequence_length
698
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16267153}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16267153}. Cell projection, cilium {ECO:0000269|PubMed:16267153}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q86SG6}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q86SG6}. Note=Predominantly cytoplasmic. Localizes to the proximal region of the primary cilium and is not observed in dividing cells. {ECO:0000269|PubMed:16267153}.
uniprot
proteins