Ell3
entrez
269344
canonical
uniprot
Q80VR2
canonical
ensembl
ENSMUSG00000027246
resolver
ensp
ENSMUSP00000028679
resolver
ensp
ENSMUSP00000112133
resolver
enst
ENSMUST00000028679
resolver
enst
ENSMUST00000116432
resolver
genesymbol
Ell3
resolver
uniprot
A2ARQ1
resolver
uniprot_entry
ELL3_MOUSE
resolver
uniprot_sec
A2ARQ1
resolver
amino_acid_sequence
MEGTQEALSGKMRLLFTPAARTSLLMLRLNEAALRALQECQQQQVRPVIAFQGHRGYLRFPGPGWSCLFSFIVSQCGQEGTNGGLDLVYQRLGRSGPNCLHCLGSLRERLTIWAAMDTIPAPLLAQEHLTEGTRESESWQDTGDEPEGHPQLAPDEVSDPLASHHEQSLPGSSSEPMAQWEMRNHTYLPSREPDQSLLSPASQKRLDKKRSAPITTEEPEEKRLRALPLASSPLQGLANQDSQEGEDWGQDEDEEGDEDGDSRLEQSLSAPSASESPSPEEVPDYLLQYRAIHSTEQQQAYEQDFETDYAEYRILHARVGAASQRFTELGAEIKRLQRGTPEHKVLEDKIVQEYKKFRKRYPSYREEKHRCEYLHQKLSHIKGLILEFEEKNRGS
uniprot
proteins
function
FUNCTION: Enhancer-binding elongation factor that specifically binds enhancers in embryonic stem cells (ES cells), marks them, and is required for their future activation during stem cell specification. Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III. Does not only bind to enhancer regions of active genes, but also marks the enhancers that are in a poised or inactive state in ES cells and is required for establishing proper RNA polymerase II occupancy at developmentally regulated genes in a cohesin-dependent manner. Probably required for priming developmentally regulated genes for later recruitment of the super elongation complex (SEC), for transcriptional activation during differentiation. Required for recruitment of P-TEFb within SEC during differentiation. Probably preloaded on germ cell chromatin, suggesting that it may prime gene activation by marking enhancers as early as in the germ cells. Promoting epithelial-mesenchymal transition (EMT). {ECO:0000269|PubMed:22768269, ECO:0000269|PubMed:23273992}.
uniprot
proteins
mass_dalton
44762
uniprot
proteins
protein_family
ELL/occludin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20159561
uniprot
proteins
pubmed
22768269
uniprot
proteins
pubmed
23273992
uniprot
proteins
sequence_length
395
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23273992}.
uniprot
proteins