SYNRG
entrez
11276
canonical
uniprot
Q9UMZ2
canonical
ensembl
ENSG00000274047
resolver
ensembl
ENSG00000275066
resolver
ensp
ENSP00000477885
resolver
ensp
ENSP00000481151
resolver
ensp
ENSP00000482962
resolver
ensp
ENSP00000483063
resolver
ensp
ENSP00000483453
resolver
ensp
ENSP00000484529
resolver
ensp
ENSP00000534348
resolver
ensp
ENSP00000534349
resolver
ensp
ENSP00000534350
resolver
ensp
ENSP00000534351
resolver
ensp
ENSP00000534352
resolver
ensp
ENSP00000534353
resolver
ensp
ENSP00000534354
resolver
ensp
ENSP00000534355
resolver
ensp
ENSP00000534357
resolver
ensp
ENSP00000534359
resolver
ensp
ENSP00000534361
resolver
ensp
ENSP00000534362
resolver
ensp
ENSP00000534363
resolver
ensp
ENSP00000534364
resolver
ensp
ENSP00000534368
resolver
ensp
ENSP00000534369
resolver
ensp
ENSP00000606343
resolver
ensp
ENSP00000606344
resolver
ensp
ENSP00000606345
resolver
ensp
ENSP00000606346
resolver
ensp
ENSP00000606347
resolver
ensp
ENSP00000606348
resolver
ensp
ENSP00000606350
resolver
ensp
ENSP00000606351
resolver
ensp
ENSP00000606352
resolver
ensp
ENSP00000642493
resolver
ensp
ENSP00000642494
resolver
genesymbol
SYNRG
resolver
genesymbol_syn
AP1GBP1
resolver
genesymbol_syn
SYNG
resolver
hgnc
HGNC:557
resolver
uniprot
A8MWU4
resolver
uniprot
B7ZKZ2
resolver
uniprot
B7ZKZ3
resolver
uniprot
Q17RI2
resolver
uniprot
Q5BKU5
resolver
uniprot
Q6ZT17
resolver
uniprot_entry
SYNRG_HUMAN
resolver
uniprot_sec
A8MWU4
resolver
uniprot_sec
B7ZKZ2
resolver
uniprot_sec
B7ZKZ3
resolver
uniprot_sec
Q17RI2
resolver
uniprot_sec
Q5BKU5
resolver
uniprot_sec
Q6ZT17
resolver
amino_acid_sequence
MALRPGAGSGGGGAAGAGAGSAGGGGFMFPVAGGIRPPQAGLMPMQQQGFPMVSVMQPNMQGIMGMNYSSQMSQGPIAMQAGIPMGPMPAAGMPYLGQAPFLGMRPPGPQYTPDMQKQFAEEQQKRFEQQQKLLEEERKRRQFEEQKQKLRLLSSVKPKTGEKSRDDALEAIKGNLDGFSRDAKMHPTPASHPKKPGPSLEEKFLVSCDISTSGQEQIKLNTSEVGHKALGPGSSKKYPSLMASNGVAVDGCVSGTTTAEAENTSDQNLSIEESGVGVFPSQDPAQPRMPPWIYNESLVPDAYKKILETTMTPTGIDTAKLYPILMSSGLPRETLGQIWALANRTTPGKLTKEELYTVLAMIAVTQRGVPAMSPDALNQFPAAPIPTLSGFSMTLPTPVSQPTVIPSGPAGSMPLSLGQPVMGINLVGPVGGAAAQASSGFIPTYPANQVVKPEEDDFQDFQDASKSGSLDDSFSDFQELPASSKTSNSQHGNSAPSLLMPLPGTKALPSMDKYAVFKGIAADKSSENTVPPGDPGDKYSAFRELEQTAENKPLGESFAEFRSAGTDDGFTDFKTADSVSPLEPPTKDKTFPPSFPSGTIQQKQQTQVKNPLNLADLDMFSSVNCSSEKPLSFSAVFSTSKSVSTPQSTGSAATMTALAATKTSSLADDFGEFSLFGEYSGLAPVGEQDDFADFMAFSNSSISSEQKPDDKYDALKEEASPVPLTSNVGSTVKGGQNSTAASTKYDVFRQLSLEGSGLGVEDLKDNTPSGKSDDDFADFHSSKFSSINSDKSLGEKAVAFRHTKEDSASVKSLDLPSIGGSSVGKEDSEDALSVQFDMKLADVGGDLKHVMSDSSLDLPTVSGQHPPAADIEDLKYAAFGSYSSNFAVSTLTSYDWSDRDDATQGRKLSPFVLSAGSGSPSATSILQKKETSFGSSENITMTSLSKVTTFVSEDALPETTFPALASFKDTIPQTSEQKEYENRDYKDFTKQDLPTAERSQEATCPSPASSGASQETPNECSDDFGEFQSEKPKISKFDFLVATSQSKMKSSEEMIKSELATFDLSVQGSHKRSLSLGDKEISRSSPSPALEQPFRDRSNTLNEKPALPVIRDKYKDLTGEVEENERYAYEWQRCLGSALNVIKKANDTLNGISSSSVCTEVIQSAQGMEYLLGVVEVYRVTKRVELGIKATAVCSEKLQQLLKDIDKVWNNLIGFMSLATLTPDENSLDFSSCMLRPGIKNAQELACGVCLLNVDSRSRKEEKPAEEHPKKAFNSETDSFKLAYGGHQYHASCANFWINCVEPKPPGLVLPDLL
uniprot
proteins
function
FUNCTION: Plays a role in endocytosis and/or membrane trafficking at the trans-Golgi network (TGN) (PubMed:15758025). May act by linking the adapter protein complex AP-1 to other proteins (Probable). Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025, ECO:0000305|PubMed:12538641}.
uniprot
proteins
mass_dalton
140654
uniprot
proteins
pubmed
10477754
uniprot
proteins
pubmed
10814529
uniprot
proteins
pubmed
12538641
uniprot
proteins
pubmed
14665628
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15758025
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28397838
uniprot
proteins
sequence_length
1314
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9JKC9}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q9JKC9}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JKC9}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15758025}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:15758025}. Note=Localization at clathrin-coated vesicles depends on AFTPH/aftiphilin (PubMed:15758025). Associates with membranes via the adapter protein complex AP-1 (By similarity). Colocalizes with AP1G1 (By similarity). {ECO:0000250|UniProtKB:Q9JKC9, ECO:0000269|PubMed:15758025}.
uniprot
proteins