Slc6a15
entrez
282712
canonical
uniprot
Q08469
canonical
ensembl
ENSRNOG00000027468
resolver
ensembl
ENSRNOG00055016667
resolver
ensembl
ENSRNOG00060004728
resolver
ensembl
ENSRNOG00065003168
resolver
ensp
ENSRNOP00000032996
resolver
ensp
ENSRNOP00055022798
resolver
ensp
ENSRNOP00060005942
resolver
ensp
ENSRNOP00065003187
resolver
enst
ENSRNOT00000029208
resolver
enst
ENSRNOT00055028317
resolver
enst
ENSRNOT00060007903
resolver
enst
ENSRNOT00065004463
resolver
genesymbol
Slc6a15
resolver
genesymbol_syn
Ntt73
resolver
uniprot
Q63838
resolver
uniprot_entry
S6A15_RAT
resolver
uniprot_sec
Q63838
resolver
amino_acid_sequence
MPKNSKVVKRDLDDDVIESVKDLLSNEDSVEDVSKKSELIVDVQEEKDTDAEDGSEVDDERPAWNSKLQYILAQVGFSVGLGNVWRFPYLCQKNGGGAYLLPYLILLLVIGIPLFFLELSVGQRIRRGSIGVWNYISPKLGGIGFASCVVCYFVALYYNVIIGWTLFYFSQSFQQPLPWDQCPLVKNASHTYIEPECEKSSATTYYWYREALAISSSISESGGLNWKMTGCLLAAWVMVCLAMIKGIQSSGKIMYFSSLFPYVVLICFLIRSLLLNGSIDGIRHMFTPKLEMMLEPKVWREAATQVFFALGLGFGGVIAFSSYNKRDNNCHFDAVLVSFINFFTSVLATLVVFAVLGFKANIVNEKCISQNSEMILKLLKTGNVSWDVIPRHINLSAVTAEDYHVVYDIIQKVKEEEFAVLHLKACQIEDELNKAVQGTGLAFIAFTEAMTHFPASPFWSVMFFLMLINLGLGSMFGTIEGIITPVVDTFKVRKEILTVICCLLAFCIGLMFVQRSGNYFVTMFDDYSATLPLLIVVILENIAVSFVYGIDKFLEDLTDMLGFAPSKYYYYMWKYISPLMLVTLLIASIVNMGLSPPGYNAWIKEKASEEFLSYPMWGMVVCFSLMVLAILPVPVVFVIRRCNLIDDSSGNLASVTYKRGRVLKEPVNLDGDDASLIHGKIPSEMSSPNFGKNIYRKQSGSPTLDTAPNGRYGIGYLMADMPDMPESDL
uniprot
proteins
function
FUNCTION: Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Can also transport low-affinity substrates such as alanine, phenylalanine, glutamine and pipecolic acid. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent. {ECO:0000250|UniProtKB:Q9H2J7}.
uniprot
proteins
mass_dalton
81596
uniprot
proteins
protein_family
SLC6A15 subfamily
uniprot
proteins
protein_family
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
uniprot
proteins
pubmed
1363329
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8738154
uniprot
proteins
sequence_length
729
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9H2J7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9H2J7}.
uniprot
proteins
transmembrane_region
TRANSMEM 70..90; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 98..117; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 142..162; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 226..244; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 253..270; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 306..323; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 335..356; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 453..472; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 496..514; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 530..550; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 571..592; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 620..642; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins