Mpig6b
entrez
106722
canonical
uniprot
D7PDD4
canonical
ensembl
ENSMUSG00000073414
resolver
ensp
ENSMUSP00000094950
resolver
ensp
ENSMUSP00000133377
resolver
enst
ENSMUST00000097337
resolver
enst
ENSMUST00000174190
resolver
genesymbol
Mpig6b
resolver
genesymbol_syn
AU023871
resolver
genesymbol_syn
G6b
resolver
genesymbol_syn
G6b-B
resolver
uniprot
D3YVS6
resolver
uniprot_entry
D3YVS6_MOUSE
resolver
uniprot_entry
G6B_MOUSE
resolver
amino_acid_sequence
MALVLPLLPLLLSKVQGNPEVSLEGSPGDRVNLSCIGVSDPTRWAWAPSFPACKGLSKGRRPILWASTRGTPTVLQHFSGRLRSLDNGIKRLELLLSAGDSGTFFCKGRHENESRTVLQVLGDKAGCRPAGSTHGYEYPKVLIPLLGVGLVLGLGVAGVVWRRRRLSPPPPPPPPPGPLPTFAPVINAEPQRPLEQESKISGHLDQEPSLHYADLDHSVLGRHRRMSTVVSGDASTVYAVVV
uniprot
proteins
function
FUNCTION: Inhibitory receptor that acts as a critical regulator of hematopoietic lineage differentiation, megakaryocyte function and platelet production (PubMed:23112346). Inhibits platelet aggregation and activation by agonists such as ADP and collagen-related peptide (By similarity). This regulation of megakaryocate function as well as platelet production ann activation is done through the inhibition (via the 2 ITIM motifs) of the receptors CLEC1B and GP6:FcRgamma signaling (PubMed:23112346). Appears to operate in a calcium-independent manner (By similarity). {ECO:0000250|UniProtKB:O95866, ECO:0000269|PubMed:23112346}.
uniprot
proteins
mass_dalton
26010
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:23112346}.; PTM: May be O-glycosylated. {ECO:0000250|UniProtKB:O95866}.; PTM: Phosphorylated. {ECO:0000269|PubMed:23112346}.
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23112346
uniprot
proteins
sequence_length
242
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:23112346}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:O95866, ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 141..161; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins