RGS6
entrez
9628
canonical
uniprot
P49758
canonical
ensembl
ENSG00000182732
resolver
ensp
ENSP00000341199
resolver
ensp
ENSP00000347699
resolver
ensp
ENSP00000383953
resolver
ensp
ENSP00000384218
resolver
ensp
ENSP00000384612
resolver
ensp
ENSP00000412144
resolver
ensp
ENSP00000450858
resolver
ensp
ENSP00000450936
resolver
ensp
ENSP00000451030
resolver
ensp
ENSP00000451855
resolver
ensp
ENSP00000452331
resolver
enst
ENST00000402788
resolver
genesymbol
RGS6
resolver
hgnc
HGNC:10002
resolver
uniprot
A0A0A0MSB1
resolver
uniprot
B7Z2A0
resolver
uniprot
B7Z2N1
resolver
uniprot
C9JE95
resolver
uniprot
F8W7W5
resolver
uniprot
O75576
resolver
uniprot
O75577
resolver
uniprot
Q2M3K2
resolver
uniprot
Q7Z4K3
resolver
uniprot
Q7Z4K4
resolver
uniprot
Q7Z4K5
resolver
uniprot
Q7Z4K6
resolver
uniprot
Q8TE13
resolver
uniprot
Q8TE14
resolver
uniprot
Q8TE15
resolver
uniprot
Q8TE16
resolver
uniprot
Q8TE17
resolver
uniprot
Q8TE18
resolver
uniprot
Q8TE19
resolver
uniprot
Q8TE20
resolver
uniprot
Q8TE21
resolver
uniprot
Q8TE22
resolver
uniprot
Q9UDS8
resolver
uniprot
Q9UDT0
resolver
uniprot
Q9Y245
resolver
uniprot
Q9Y647
resolver
uniprot_entry
A0A0A0MSB1_HUMAN
resolver
uniprot_entry
B7Z2A0_HUMAN
resolver
uniprot_entry
B7Z2N1_HUMAN
resolver
uniprot_entry
Q2M3K2_HUMAN
resolver
uniprot_entry
RGS6_HUMAN
resolver
uniprot_sec
C9JE95
resolver
uniprot_sec
F8W7W5
resolver
uniprot_sec
O75576
resolver
uniprot_sec
O75577
resolver
uniprot_sec
Q7Z4K3
resolver
uniprot_sec
Q7Z4K4
resolver
uniprot_sec
Q7Z4K5
resolver
uniprot_sec
Q7Z4K6
resolver
uniprot_sec
Q8TE13
resolver
uniprot_sec
Q8TE14
resolver
uniprot_sec
Q8TE15
resolver
uniprot_sec
Q8TE16
resolver
uniprot_sec
Q8TE17
resolver
uniprot_sec
Q8TE18
resolver
uniprot_sec
Q8TE19
resolver
uniprot_sec
Q8TE20
resolver
uniprot_sec
Q8TE21
resolver
uniprot_sec
Q8TE22
resolver
uniprot_sec
Q9UDS8
resolver
uniprot_sec
Q9UDT0
resolver
uniprot_sec
Q9Y245
resolver
uniprot_sec
Q9Y647
resolver
amino_acid_sequence
MAQGSGDQRAVGVADPEESSPNMIVYCKIEDIITKMQDDKTGGVPIRTVKSFLSKIPSVVTGTDIVQWLMKNLSIEDPVEAIHLGSLIAAQGYIFPISDHVLTMKDDGTFYRFQAPYFWPSNCWEPENTDYAIYLCKRTMQNKARLELADYEAENLARLQRAFARKWEFIFMQAEAQVKIDRKKDKTERKILDSQERAFWDVHRPVPGCVNTTEMDIRKCRRLKNPQKVKKSVYGVTEESQAQSPVHVLSQPIRKTTKEDIRKQITFLNAQIDRHCLKMSKVAESLIAYTEQYVEYDPLITPAEPSNPWISDDVALWDIEMSKEPSQQRVKRWGFSFDEILKDQVGRDQFLRFLESEFSSENLRFWLAVQDLKKQPLQDVAKRVEEIWQEFLAPGAPSAINLDSHSYEITSQNVKDGGRYTFEDAQEHIYKLMKSDSYARFLRSNAYQDLLLAKKKGKSLAGKRLTGLMQSS
uniprot
proteins
function
FUNCTION: Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS6/GNB5 dimer enhances GNAO1 GTPase activity (PubMed:10521509). {ECO:0000269|PubMed:10521509}.
uniprot
proteins
mass_dalton
54423
uniprot
proteins
mutagenesis
MUTAGEN 297; /note="D->A: Loss of interaction with GNB5."; /evidence="ECO:0000269|PubMed:10339615"; MUTAGEN 309; /note="W->F: Diminishes interaction with GNB5."; /evidence="ECO:0000269|PubMed:10339615
uniprot
proteins
pubmed
10339615
uniprot
proteins
pubmed
10521509
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
12761221
uniprot
proteins
pubmed
18434541
uniprot
proteins
pubmed
7596406
uniprot
proteins
sequence_length
472
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12761221}. Cytoplasm, cytosol {ECO:0000269|PubMed:10521509}. Membrane {ECO:0000269|PubMed:10521509}; Peripheral membrane protein {ECO:0000269|PubMed:10521509}. Nucleus {ECO:0000269|PubMed:12761221}. Cell membrane {ECO:0000250|UniProtKB:Q9Z2H2}. Note=Interaction with GNB5 mediates translocation to the nucleus. {ECO:0000269|PubMed:12761221}.
uniprot
proteins