DNAJB9
entrez
4189
canonical
uniprot
Q9UBS3
canonical
ensembl
ENSG00000128590
resolver
ensp
ENSP00000249356
resolver
ensp
ENSP00000530532
resolver
ensp
ENSP00000530533
resolver
ensp
ENSP00000530534
resolver
ensp
ENSP00000530535
resolver
enst
ENST00000249356
resolver
enst
ENST00000860473
resolver
enst
ENST00000860474
resolver
enst
ENST00000860475
resolver
enst
ENST00000860476
resolver
genesymbol
DNAJB9
resolver
genesymbol_syn
MDG1
resolver
genesymbol_syn
MST049
resolver
hgnc
HGNC:6968
resolver
uniprot
Q6FIF1
resolver
uniprot_entry
DNJB9_HUMAN
resolver
uniprot_entry
Q6FIF1_HUMAN
resolver
amino_acid_sequence
MATPQSIFIFAICILMITELILASKSYYDILGVPKSASERQIKKAFHKLAMKYHPDKNKSPDAEAKFREIAEAYETLSDANRRKEYDTLGHSAFTSGKGQRGSGSSFEQSFNFNFDDLFKDFGFFGQNQNTGSKKRFENHFQTRQDGGSSRQRHHFQEFSFGGGLFDDMFEDMEKMFSFSGFDSTNQHTVQTENRFHGSSKHCRTVTQRRGNMVTTYTDCSGQ
uniprot
proteins
function
FUNCTION: Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (PubMed:18400946). In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity). Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production (By similarity). {ECO:0000250|UniProtKB:G3H0N9, ECO:0000250|UniProtKB:Q9QYI6, ECO:0000269|PubMed:18400946}.
uniprot
proteins
mass_dalton
25518
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
11836248
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18400946
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
223
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:Q9QYI6}.
uniprot
proteins