RFTN2
entrez
130132
canonical
uniprot
Q52LD8
canonical
ensembl
ENSG00000162944
resolver
ensp
ENSP00000295049
resolver
ensp
ENSP00000540750
resolver
ensp
ENSP00000540751
resolver
enst
ENST00000295049
resolver
genesymbol
RFTN2
resolver
genesymbol_syn
C2orf11
resolver
hgnc
HGNC:26402
resolver
uniprot
Q14DH4
resolver
uniprot
Q2TA69
resolver
uniprot
Q53QE0
resolver
uniprot
Q53SE1
resolver
uniprot
Q96NM3
resolver
uniprot_entry
RFTN2_HUMAN
resolver
uniprot_sec
Q14DH4
resolver
uniprot_sec
Q2TA69
resolver
uniprot_sec
Q53QE0
resolver
uniprot_sec
Q53SE1
resolver
uniprot_sec
Q96NM3
resolver
amino_acid_sequence
MGCGLRKLEDPDDSSPGKIFSTLKRPQVETKTEFAYEYVLLDFTLQASSNPEVIKINSILDIVTKVENYYLKGYIVGAIHPVIQPVGQRKHLPASYLYRVVLLRLKLSPKNSAAPSGQRRPRLVIEECPLTSEAQTNDAAKELIEKINVAAKRGMKFVGFISQHYSPSKFCNGTNHDGDIESMLHVRHGSDENCRSWNEGTLSGQSSESGIEEELHHESGQYQMEQNGSPTSSKSRKGEASDNKLYTVFNAFDDDSTSWAYQEGILSMKVTRKGSVISTLDADWLELTTFYYKQGLSLIDSFVFWETSKGEHLPKSLEGFFIYEEEGSGVPGSSRKGNDAIVVEQWTVIEGCEIKTDYGPLLHTLAEFGWLLTSVLPTPVLRHDSEGNLATKQIVFLQRPVMWNSAAQTPDKKASRHIKGEDKNKATSRSIGLDTTSSQPAESRHLPEECRLSPSRECWTKEGRLAQHNSFSGFSSSDNVLRELDDGQFDQEDGVTQVTCM
uniprot
proteins
function
FUNCTION: Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling. {ECO:0000250|UniProtKB:Q8CHX7}.
uniprot
proteins
mass_dalton
55922
uniprot
proteins
protein_family
Raftlin family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
sequence_length
501
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q14699}; Lipid-anchor {ECO:0000250|UniProtKB:Q14699}.
uniprot
proteins