SH3PXD2A
entrez
9644
canonical
uniprot
Q5TCZ1
canonical
ensembl
ENSG00000107957
resolver
ensp
ENSP00000348215
resolver
ensp
ENSP00000358789
resolver
genesymbol
SH3PXD2A
resolver
genesymbol_syn
FISH
resolver
genesymbol_syn
KIAA0418
resolver
genesymbol_syn
SH3MD1
resolver
genesymbol_syn
TKS5
resolver
hgnc
HGNC:23664
resolver
uniprot
B3KPL1
resolver
uniprot
B7Z9L8
resolver
uniprot
D3DR98
resolver
uniprot
O43302
resolver
uniprot
Q5TCZ2
resolver
uniprot
Q5TDQ8
resolver
uniprot_entry
B3KPL1_HUMAN
resolver
uniprot_entry
B7Z9L8_HUMAN
resolver
uniprot_entry
SPD2A_HUMAN
resolver
uniprot_sec
D3DR98
resolver
uniprot_sec
O43302
resolver
uniprot_sec
Q5TCZ2
resolver
uniprot_sec
Q5TDQ8
resolver
amino_acid_sequence
MLAYCVQDATVVDVEKRRNPSKHYVYIINVTWSDSTSQTIYRRYSKFFDLQMQLLDKFPIEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLKPIDEYCRALVRLPPHISQCDEVFRFFEARPEDVNPPKEDYGSSKRKSVWLSSWAESPKKDVTGADATAEPMILEQYVVVSNYKKQENSELSLQAGEVVDVIEKNESGWWFVSTSEEQGWVPATYLEAQNGTRDDSDINTSKTGEVSKRRKAHLRRLDRRWTLGGMVNRQHSREEKYVTVQPYTSQSKDEIGFEKGVTVEVIRKNLEGWWYIRYLGKEGWAPASYLKKAKDDLPTRKKNLAGPVEIIGNIMEISNLLNKKASGDKETPPAEGEGHEAPIAKKEISLPILCNASNGSAVGVPDRTVSRLAQGSPAVARIAPQRAQISSPNLRTRPPPRRESSLGFQLPKPPEPPSVEVEYYTIAEFQSCISDGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKPNLSRRTSTLTRPKVPPPAPPSKPKEAEEGPTGASESQDSPRKLKYEEPEYDIPAFGFDSEPELSEEPVEDRASGERRPAQPHRPSPASSLQRARFKVGESSEDVALEEETIYENEGFRPYAEDTLSARGSSGDSDSPGSSSLSLTRKNSPKSGSPKSSSLLKLKAEKNAQAEMGKNHSSASFSSSITINTTCCSSSSSSSSSLSKTSGDLKPRSASDAGIRGTPKVRAKKDADANAGLTSCPRAKPSVRPKPFLNRAESQSQEKMDISTLRRQLRPTGQLRGGLKGSKSEDSELPPQTASEAPSEGSRRSSSDLITLPATTPPCPTKKEWEGPATSYMTCSAYQKVQDSEISFPAGVEVQVLEKQESGWWYVRFGELEGWAPSHYLVLDENEQPDPSGKELDTVPAKGRQNEGKSDSLEKIERRVQALNTVNQSKKATPPIPSKPPGGFGKTSGTPAVKMRNGVRQVAVRPQSVFVSPPPKDNNLSCALRRNESLTATDGLRGVRRNSSFSTARSAAAEAKGRLAERAASQGSDSPLLPAQRNSIPVSPVRPKPIEKSQFIHNNLKDVYVSIADYEGDEETAGFQEGVSMEVLERNPNGWWYCQILDGVKPFKGWVPSNYLEKKN
uniprot
proteins
function
FUNCTION: Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide. {ECO:0000269|PubMed:12615925, ECO:0000269|PubMed:15710328, ECO:0000269|PubMed:15710903, ECO:0000269|PubMed:19755710, ECO:0000269|PubMed:20609497, ECO:0000269|PubMed:27789576}.
uniprot
proteins
mass_dalton
125289
uniprot
proteins
mutagenesis
MUTAGEN 24; /note="Y->A: Loss of interaction with RAB40B."; /evidence="ECO:0000269|PubMed:27789576"; MUTAGEN 42; /note="R->A: Loss of binding to (PtdIns(3)P) and (PtdIns(3,4)P2)."; /evidence="ECO:0000269|PubMed:12615925"; MUTAGEN 93; /note="R->A: Loss of binding to (PtdIns(3)P) and (PtdIns(3,4)P2)."; /evidence="ECO:0000269|PubMed:12615925
uniprot
proteins
post_translational_modification
PTM: Tyrosine phosphorylated by SRC. Phosphorylation plays a regulatory role in the protein localization. The intramolecular interaction of the PX domain with the third SH3 domain maintains the protein in the cytoplasm and phosphorylation disrupts this interaction, resulting in the redistribution of the protein from cytoplasm to the perimembrane region. Phosphorylated on serine upon DNA damage, probably by ATM or ATR.
uniprot
proteins
protein_family
SH3PXD2 family
uniprot
proteins
pubmed
12615925
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15710328
uniprot
proteins
pubmed
15710903
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18417249
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19755710
uniprot
proteins
pubmed
19807924
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20609497
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27789576
uniprot
proteins
pubmed
9455477
uniprot
proteins
sequence_length
1133
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cell projection, podosome {ECO:0000269|PubMed:12615925}. Note=Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells. {ECO:0000269|PubMed:12615925}.
uniprot
proteins