P0DP24
uniprot
P0DP24
canonical
activity_regulation
ACTIVITY REGULATION: (Microbial infection) Inactivated by S.flexneri OspC1 and OspC3 proteins, which specifically bind the apo-form of calmodulin, thereby preventing calcium-binding and activity. {ECO:0000269|PubMed:35568036}.
uniprot
proteins
amino_acid_sequence
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK
uniprot
proteins
disease_involvement
DISEASE: Long QT syndrome 15 (LQT15) [MIM:616249]: A form of long QT syndrome, a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. {ECO:0000269|PubMed:23388215, ECO:0000269|PubMed:24917665, ECO:0000269|PubMed:26164367, ECO:0000269|PubMed:26969752, ECO:0000269|PubMed:27165696, ECO:0000269|PubMed:27516456}. Note=The disease is caused by variants affecting the gene represented in this entry. Mutations in CALM2 are the cause of LQT15.
uniprot
proteins
function
FUNCTION: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (PubMed:16760425, PubMed:26969752, PubMed:27165696). Calcium-binding is required for the activation of calmodulin (PubMed:16760425, PubMed:26969752, PubMed:27165696, PubMed:35568036). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (PubMed:16760425, PubMed:26969752, PubMed:27165696, PubMed:35568036). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (PubMed:16760425). Mediates calcium-dependent inactivation of CACNA1C (PubMed:26969752). Positively regulates calcium-activated potassium channel activity of KCNN2 (PubMed:27165696). {ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:26969752, ECO:0000269|PubMed:27165696, ECO:0000269|PubMed:35568036}.; FUNCTION: (Microbial infection) Required for C.violaceum CopC and S.flexneri OspC3 arginine ADP-riboxanase activity. {ECO:0000269|PubMed:35338844, ECO:0000269|PubMed:35446120, ECO:0000269|PubMed:36423631, ECO:0000269|PubMed:36624349}.
uniprot
proteins
mass_dalton
16838
uniprot
proteins
post_translational_modification
PTM: Ubiquitination results in a strongly decreased activity. {ECO:0000250}.; PTM: Phosphorylation results in a decreased activity. {ECO:0000250}.
uniprot
proteins
protein_family
Calmodulin family
uniprot
proteins
pubmed
12871148
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
1474585
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15746192
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16127172
uniprot
proteins
pubmed
16760425
uniprot
proteins
pubmed
17719545
uniprot
proteins
pubmed
18650434
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20466722
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22484487
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23109337
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23388215
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2445749
uniprot
proteins
pubmed
24917665
uniprot
proteins
pubmed
25582440
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26164367
uniprot
proteins
pubmed
26969752
uniprot
proteins
pubmed
27165696
uniprot
proteins
pubmed
27516456
uniprot
proteins
pubmed
27564677
uniprot
proteins
pubmed
27876793
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
35338844
uniprot
proteins
pubmed
35446120
uniprot
proteins
pubmed
35568036
uniprot
proteins
pubmed
36423631
uniprot
proteins
pubmed
36624349
uniprot
proteins
pubmed
38297121
uniprot
proteins
pubmed
7093203
uniprot
proteins
pubmed
9681195
uniprot
proteins
pubmed
9804419
uniprot
proteins
sequence_length
149
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:16760425}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:16760425}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843}. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules.
uniprot
proteins