Gphr
entrez
67549
canonical
uniprot
Q8BS95
canonical
ensembl
ENSMUSG00000028096
resolver
ensp
ENSMUSP00000029738
resolver
enst
ENSMUST00000029738
resolver
genesymbol
Gphr
resolver
genesymbol_syn
Gpr89
resolver
genesymbol_syn
Gpr89a
resolver
uniprot
Q9D455
resolver
uniprot_entry
GPHR_MOUSE
resolver
uniprot_sec
Q9D455
resolver
amino_acid_sequence
MSFLIDSSIMITSQILFFGFGWLFFMRQLFKDYEVRQYVVQVIFSVTFAFSCTMFELIIFEILGVLNSSSRYFHWKLNLCVILLILVFMVPFYIGYFIVSNIQLLHKQRLLFSCLLWLTFMYFFWKLGDPFPILSPKHGILSIEQLISRVGVIGVTLMALLSGFGAVNCPYTYMSYFLRNVTDTDILALERRLLQTMDMIISKKKRMAVARRTMFQRGDVQNKPSGLWGMLKSVTASAPGSENLTLIQQEVDALEELSRQLFLETADLYATKERIEYSKTFKGKYFNFLGYFFSIYCVWKIFMATINIVLDRVGKTDPVTRGIEITVNYLGIQFDVKFWSQHISFILVGIIIVTSIRGLLITLTKFFYAISSSKSSNVIVLLLAQIMGMYFVSSVLLIRMSMPPEYRTIITEVLGELQFNFYHRWFDVIFLVSALSSILFLYLAHKQAPEKHMAP
uniprot
proteins
function
FUNCTION: Voltage-gated channel that enables the transfer of monoatomic anions such as iodide, chloride, bromide and fluoride which may function in counter-ion conductance and participates in Golgi acidification (By similarity). Plays a role in lymphocyte development, probably by acting as a RABL3 effector in hematopoietic cells (PubMed:32220963). Essential for maintaining the acidic luminal pH of the Golgi apparatus in neurons, which is important for preserving Golgi structural integrity (PubMed:31118204, PubMed:36056653). This integrity supports proper axonal transport and synaptic maintenance in cerebellar inhibitory neurons, including Purkinje and basket cells (PubMed:31118204). Additionally, Golgi acidification facilitates the activation of SREBP2, thereby ensuring sufficient cholesterol biosynthesis necessary for normal neuronal morphology and function (PubMed:36056653). {ECO:0000250|UniProtKB:B7ZAQ6, ECO:0000269|PubMed:31118204, ECO:0000269|PubMed:32220963, ECO:0000269|PubMed:36056653}.
uniprot
proteins
mass_dalton
52735
uniprot
proteins
mutagenesis
MUTAGEN 273..303; /note="Missing: In explorer; no obvious external deformities but mutants are 40% smaller than wild-type litter mates and show reduced frequency of CD3+ T cells, CD4+ T cells and CD8+ T cells which all display elevated CD44 expression."; /evidence="ECO:0000269|PubMed:32220963
uniprot
proteins
protein_family
Golgi pH regulator (TC 1.A.38) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31118204
uniprot
proteins
pubmed
32220963
uniprot
proteins
pubmed
36056653
uniprot
proteins
sequence_length
455
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:B7ZAQ6}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..25; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 46..66; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 79..99; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 114..134; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 150..170; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 288..308; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 343..363; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 378..398; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 425..445; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins