P14426
uniprot
P14426
canonical
amino_acid_sequence
MGAMVPRTLLLLLAAALAPAQTRAGPHSLRYFETVVSRPGLGEPRFISVGYVDNTEFVRFDSDAENPRDEPRVRWMEQEGPEYWERETQIAKGNEQSFRVDLRTLLRYYNQSEGGSHTIQRLSGCDVGSDWRLLRGYEQFAYDGCDYIALNEDLKTWTAADMAALITKHKWEQAGAAERDRAYLEGTCVEWLRRYLELGNATLLHTDSPKAHVTHHPRSKVEVTLRCWALGFYPADITLTWQLNGEELTQDMELVETRPAGDGTFQKWASVVVPLGKEQNYTCHVYHEGLPEPLTLRWEPPPSTDSYMVIVAVLGVLGAVAIIGAVVAFVMMMRRNTGGKGGDYTLTPGSQSSEMSLPDCKA
uniprot
proteins
function
FUNCTION: Involved in the presentation of foreign antigens to the immune system.
uniprot
proteins
mass_dalton
40620
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated in case of infection by murid herpesvirus 4, by the viral E3 ligase K3 (mK3), leading to target the protein for rapid degradation by the endoplasmic reticulum-associated degradation (ERAD) system. Ubiquitination takes place on lysine, as well as serine and threonine residues present in the cytoplasmic tail. Hydroxylated serine and threonine residues in the cytoplasmic tail are subject to ubiquitination via ester bonds instead of the classical isopeptide linkage (Probable). {ECO:0000305|PubMed:11672544}.; PTM: Hydroxylation of residues in the cytoplasmic tail. {ECO:0000250}.
uniprot
proteins
protein_family
MHC class I family
uniprot
proteins
pubmed
11672544
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
3680952
uniprot
proteins
sequence_length
362
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 307..333; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins