Farp2
entrez
227377
canonical
uniprot
Q91VS8
canonical
ensembl
ENSMUSG00000034066
resolver
ensp
ENSMUSP00000112725
resolver
enst
ENSMUST00000120301
resolver
genesymbol
Farp2
resolver
genesymbol_syn
Kiaa0793
resolver
uniprot
E9QJS4
resolver
uniprot
Q3TAP2
resolver
uniprot
Q69ZZ0
resolver
uniprot_entry
FARP2_MOUSE
resolver
uniprot_sec
E9QJS4
resolver
uniprot_sec
Q3TAP2
resolver
uniprot_sec
Q69ZZ0
resolver
amino_acid_sequence
MGEIEGTYRALPTSGTRLGGQTAIGVSTLEPEQSLSPRMQEKHMRIRVKLLDSTVELFDIEPKCDGQVLLTQVWKHLNLIECDYFGLEFKNVQSYWIWLEPMKPIIRQVRKPKNAVLRLAVKFFPPDPGQLQEEYTRYLFALQLKRDLLEERLTCTANTAALLISHLLQSEIGDYDETLDREHLKANEYLPNQEKSLEKILDFHQRHTGQTPAESDFQVLEIARKLEMYGIRFHMASDREGTKINLAVSHMGVLVFQGTTKINTFNWSKVRKLSFKRKRFLIKLHPEVHGPYQDTLEFLLGSRDECKNFWKICVEYHTFFRLSDQPKPKAKAVFFSRGSSFRYSGRTQKQLVDYVKDGGMKRIPYERRHSKTRTSLHALTVDLPKQSVSFTDGLRTSASLSSANVSFYPPPSSSLSPPGLPNLKDSSSSLVDPQAPVIKSTAAERSSGPSSSDGPSTQSAHLPGPPVLRPGPGFSMDSPQPSPSSLKSHLSLCPELQAALSTAEQGASPVLSPVLSGAGTARMDNQEEQKHKHMPEDEAYFIAKEILATERTYLKDLEVITVWFRSVLIKEEAMPAALMALLFSNIDPVYEFHRGFLHEVEQRLALWEGPSSAHLKGDHQRIGDILLRNMRQLKEFTSYFQRHDEVLTELEKATKHCKKLEAVYKEFELQKVCYLPLNTFLLKPVQRLVHYRLLLSRLCAHYSPGHRDYADCHEALKAITEVTTELQQSLTRLENLQKLTELQRDLVGVENLIAPGREFIREGCLHKLTKKGLQQRMFFLFSDMLLYTSKSVTGASHFRIRGFLPLRGMLVEESENEWSVPHCFTIYAAQKTIVVAASTRLEKEKWMQDLNAAIQAAKTIGDSPPVLLGGPVYTRTPRSSDEVSLEESEDGRGNRGSLEGNSQHRANTTMHVCWYRNTSVSRADHSAAVENQLSGYLLRKFKNSNGWQKLWVVFTNFCLFFYKTHQDDYPLASLPLLGYSVSLPREADSIHKDYVFKLQFKSHVYFFRAESKYTFERWMDVIKRASSSPGRPPSFTQDCSHHSPGLEAEIREKEACPSPCLDKNL
uniprot
proteins
function
FUNCTION: Functions as a guanine nucleotide exchange factor that activates RAC1. May have relatively low activity (PubMed:20702777, PubMed:23375260). Plays a role in the response to class 3 semaphorins and remodeling of the actin cytoskeleton. Plays a role in TNFSF11-mediated osteoclast differentiation, especially in podosome rearrangement and reorganization of the actin cytoskeleton. Regulates the activation of ITGB3, integrin signaling and cell adhesion. {ECO:0000269|PubMed:12351724, ECO:0000269|PubMed:16286926, ECO:0000269|PubMed:20702777, ECO:0000269|PubMed:23375260}.
uniprot
proteins
mass_dalton
121281
uniprot
proteins
mutagenesis
MUTAGEN 730; /note="L->R: Increases guanyl-nucleotide exchange factor activity with RAC1; when associated with Q-733."; /evidence="ECO:0000269|PubMed:23375260"; MUTAGEN 733; /note="L->Q: Increases guanyl-nucleotide exchange factor activity with RAC1; when associated with R-730."; /evidence="ECO:0000269|PubMed:23375260
uniprot
proteins
pubmed
12351724
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16286926
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20702777
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23375260
uniprot
proteins
sequence_length
1065
uniprot
proteins