Pyy
entrez
287730
canonical
uniprot
P10631
canonical
ensembl
ENSRNOG00000020877
resolver
ensembl
ENSRNOG00055033311
resolver
ensembl
ENSRNOG00060013497
resolver
ensembl
ENSRNOG00065027096
resolver
ensp
ENSRNOP00000028323
resolver
ensp
ENSRNOP00055047471
resolver
ensp
ENSRNOP00060018247
resolver
ensp
ENSRNOP00065038310
resolver
enst
ENSRNOT00055057579
resolver
enst
ENSRNOT00060023031
resolver
enst
ENSRNOT00065046728
resolver
genesymbol
Pyy
resolver
uniprot
Q3C1E8
resolver
uniprot_entry
PYY_RAT
resolver
uniprot_sec
Q3C1E8
resolver
amino_acid_sequence
MVAVRRPWPVMVAMLLVLLACLGALVDAYPAKPEAPGEDASPEELSRYYASLRHYLNLVTRQRYGKREVPAALFSKLLFTDDSENLPFRSRPEGVDQW
uniprot
proteins
function
FUNCTION: [Peptide YY]: Ligand for neuropeptide Y receptor type 1 (NPY1R) and neuropeptide Y receptor type 2 (NPY2R). Also binds NPY5R. Receptor binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production. Receptor activation by PYY also leads to an increase of intracellular Ca(2+) levels (By similarity). This gut peptide inhibits exocrine pancreatic secretion (By similarity). Involved in the regulation of colonic antisecretory tone, and colonic contractility (By similarity). {ECO:0000250|UniProtKB:P10082, ECO:0000250|UniProtKB:P68005, ECO:0000250|UniProtKB:Q9EPS2}.; FUNCTION: [Peptide YY(3-36)]: Is a NPY2R agonist involved in the down-regulation of appetite and food intake, probably acting on receptors located on proopiomelanocortin(POMC)-releasing and neuropeptide Y(NPY)-releasing neurons in the arcuate nucleus of hypothalamus (PubMed:12167864). In NPY-releasing neurons, NPY2R activation by PYY(3-36) leads to membrane hyperpolarization and reduced release of the orexigenic neuropeptide NPY (By similarity). {ECO:0000250|UniProtKB:Q9EPS2, ECO:0000269|PubMed:12167864}.
uniprot
proteins
mass_dalton
11121
uniprot
proteins
post_translational_modification
PTM: The peptide YY form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro) to generate peptide YY(3-36). {ECO:0000250|UniProtKB:P10082}.
uniprot
proteins
protein_family
NPY family
uniprot
proteins
pubmed
12167864
uniprot
proteins
pubmed
1890992
uniprot
proteins
pubmed
3413293
uniprot
proteins
pubmed
3654598
uniprot
proteins
sequence_length
98
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Peptide YY]: Secreted {ECO:0000250|UniProtKB:P10082}.
uniprot
proteins