Nos3
entrez
24600
canonical
uniprot
Q62600
canonical
ensembl
ENSRNOG00000009348
resolver
ensp
ENSRNOP00000013058
resolver
ensp
ENSRNOP00000086104
resolver
enst
ENSRNOT00000118104
resolver
genesymbol
Nos3
resolver
uniprot
A0A8I6A2Y1
resolver
uniprot
O88672
resolver
uniprot
O89041
resolver
uniprot
Q62734
resolver
uniprot
Q68GV6
resolver
uniprot
Q75NE4
resolver
uniprot_entry
A0A8I6A2Y1_RAT
resolver
uniprot_entry
NOS3_RAT
resolver
uniprot_sec
O88672
resolver
uniprot_sec
O89041
resolver
uniprot_sec
Q62734
resolver
uniprot_sec
Q68GV6
resolver
uniprot_sec
Q75NE4
resolver
activity_regulation
ACTIVITY REGULATION: Stimulated by calcium/calmodulin. Inhibited by NOSIP and NOSTRIN (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MGNLKSVGQEPGPPCGLGLGLGLGLCGKQGPASPAPEPSQAPVPPSPTRPAPDHSPPLTRPPDGPKFPRVKNWEVGSITYDTLSAQAQQDGPCTPRRCLGSLVFPRKLQSRPTQGPSPTEQLLGQARDFINQYYNSIKRSGSQAHEQRLQEVEAEVVATGTYQLRESELVFGAKQAWRNAPRCVGRIQWGKLQVFDARDCRTAQEMFTYICNHIKYATNRGNLRSAITVFPQRYAGRGDFRIWNSQLVRYAGYRQQDGSVRGDPANVEITELCIQHGWTPGNGRFDVLPLLLQAPDEPPELFTLPPELVLEVPLEHPTLEWFAALGLRWYALPAVSNMLLEIGGLEFPAAPFSGWYMSSEIGMRDLCDPHRYNILEDVAVCMDLDTRTTSSLWKDKAAVEINVAVLYSYQLAKVTIVDHHAATASFMKHLENEQKARGGCPADWAWIVPPISGSLTPVFHQEMVNYFLSPAFRYQPDPWKGSAAKGTGITRKKTFKEVANAVKISASLMGTVMAKRVKATILYGSETGRAQSYAQQLGRLFRKAFDPRVLCMDEYDVVSLEHEALVLVVTSTFGNGDPPENGESFAAALMEMSGPYNSSPRPEQHKSYKIRFNSVSCSDPLVSSWRRKRKESSNTDSAGALGTLRFCVFGLGSRAYPHFCAFARAVDTRLEELGGERLLQLGQGDELCGQEEAFRGWAQAAFQAACETFCVGEDAKAAARDIFSPKRSWKRQRYRLSTQAESLQLLPRLTHVHRRKMFQATILSVENLQSSKSTRATILVRLDTGSQEGLQYQPGDHIGVCPPNRPGLVEALLSRVEDPPPSTEPVAVEQLEKGSPGGPPPGWVRDPRLPPCTLRQALTYFLDITSPPSPRLLRLLSTLAEESSEQQELEALSQDPRRYEEWKWFRCPTLLEVLEQFPSVALPAPLILTQLPLLQPRYYSVSSAPSAHPGEIHLTVAVLAYRTQDGLGPLHYGVCSTWMSQLKAGDPVPCFIRGAPSFRLPPDPNLPCILVGPGTGIAPFRGFWQDRLHDIEIKGLQPAPMTLVFGCRCSQLDHLYRDEVLDAQQRGVFGQVLTAFSRDPGSPKTYVQDLLRTELAAEVHRVLCLEQGHMFVCGDVTMATSVLQTVQRILATEGSMELDEAGDVIGVLRDQQRYHEDIFGLTLRTQEVTSRIRTQSFSLQERQLRGAVPWSFDPPTQETPGS
uniprot
proteins
ec_number
1.14.13.39
uniprot
proteins
function
FUNCTION: Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets. {ECO:0000250|UniProtKB:P29474}.
uniprot
proteins
mass_dalton
133290
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by AMPK at Ser-1176 in the presence of Ca(2+)-calmodulin (CaM) activates activity. In absence of Ca(2+)-calmodulin, AMPK also phosphorylates Thr-494, resulting in inhibition of activity. {ECO:0000269|PubMed:10025949}.
uniprot
proteins
protein_family
NOS family
uniprot
proteins
pubmed
10025949
uniprot
proteins
pubmed
15105416
uniprot
proteins
pubmed
15808839
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7527874
uniprot
proteins
pubmed
7537461
uniprot
proteins
sequence_length
1202
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane, caveola {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Golgi apparatus {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle, which is favored by interaction with NOSIP and results in a reduced enzymatic activity. {ECO:0000250}.
uniprot
proteins