PAAF1
entrez
80227
canonical
uniprot
Q9BRP4
canonical
ensembl
ENSG00000175575
resolver
ensp
ENSP00000311665
resolver
ensp
ENSP00000438071
resolver
ensp
ENSP00000438124
resolver
ensp
ENSP00000441333
resolver
ensp
ENSP00000441494
resolver
ensp
ENSP00000707869
resolver
enst
ENST00000544909
resolver
genesymbol
PAAF1
resolver
genesymbol_syn
WDR71
resolver
hgnc
HGNC:25687
resolver
uniprot
A6NDR5
resolver
uniprot
B4DPB0
resolver
uniprot
B7ZAS9
resolver
uniprot
F5H0C4
resolver
uniprot
Q4G165
resolver
uniprot
Q53HS9
resolver
uniprot
Q7Z500
resolver
uniprot
Q8TBU6
resolver
uniprot
Q9HAB6
resolver
uniprot_entry
F5H0C4_HUMAN
resolver
uniprot_entry
PAAF1_HUMAN
resolver
uniprot_sec
A6NDR5
resolver
uniprot_sec
B4DPB0
resolver
uniprot_sec
B7ZAS9
resolver
uniprot_sec
Q4G165
resolver
uniprot_sec
Q53HS9
resolver
uniprot_sec
Q7Z500
resolver
uniprot_sec
Q8TBU6
resolver
uniprot_sec
Q9HAB6
resolver
amino_acid_sequence
MAAPLRIQSDWAQALRKDEGEAWLSCHPPGKPSLYGSLTCQGIGLDGIPEVTASEGFTVNEINKKSIHISCPKENASSKFLAPYTTFSRIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVGAADNSINLGSPEQMPSEREVGTEAKMLLLAREDKKLQCLGLQSRQLVFLFIGSDAFNCCTFLSGFLLLAGTQDGNIYQLDVRSPRAPVQVIHRSGAPVLSLLSVRDGFIASQGDGSCFIVQQDLDYVTELTGADCDPVYKVATWEKQIYTCCRDGLVRRYQLSDL
uniprot
proteins
function
FUNCTION: Inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes provirus transcription efficiency. Protects SUPT6H from proteasomal degradation. {ECO:0000269|PubMed:15831487, ECO:0000269|PubMed:17289585, ECO:0000269|PubMed:22316138}.
uniprot
proteins
mass_dalton
42190
uniprot
proteins
protein_family
WD repeat PAAF1/RPN14 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15831487
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17289585
uniprot
proteins
pubmed
17323924
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22316138
uniprot
proteins
sequence_length
392
uniprot
proteins