APCDD1
entrez
147495
canonical
uniprot
Q8J025
canonical
ensembl
ENSG00000154856
resolver
ensp
ENSP00000347433
resolver
enst
ENST00000355285
resolver
genesymbol
APCDD1
resolver
genesymbol_syn
DRAPC1
resolver
hgnc
HGNC:15718
resolver
uniprot
B4DUQ0
resolver
uniprot
B4DZT0
resolver
uniprot
Q71M25
resolver
uniprot_entry
APCD1_HUMAN
resolver
uniprot_sec
B4DUQ0
resolver
uniprot_sec
B4DZT0
resolver
uniprot_sec
Q71M25
resolver
amino_acid_sequence
MSWPRRLLLRYLFPALLLHGLGEGSALLHPDSRSHPRSLEKSAWRAFKESQCHHMLKHLHNGARITVQMPPTIEGHWVSTGCEVRSGPEFITRSYRFYHNNTFKAYQFYYGSNRCTNPTYTLIIRGKIRLRQASWIIRGGTEADYQLHNVQVICHTEAVAEKLGQQVNRTCPGFLADGGPWVQDVAYDLWREENGCECTKAVNFAMHELQLIRVEKQYLHHNLDHLVEELFLGDIHTDATQRMFYRPSSYQPPLQNAKNHDHACIACRIIYRSDEHHPPILPPKADLTIGLHGEWVSQRCEVRPEVLFLTRHFIFHDNNNTWEGHYYHYSDPVCKHPTFSIYARGRYSRGVLSSRVMGGTEFVFKVNHMKVTPMDAATASLLNVFNGNECGAEGSWQVGIQQDVTHTNGCVALGIKLPHTEYEIFKMEQDARGRYLLFNGQRPSDGSSPDRPEKRATSYQMPLVQCASSSPRAEDLAEDSGSSLYGRAPGRHTWSLLLAALACLVPLLHWNIRR
uniprot
proteins
disease_involvement
DISEASE: Hypotrichosis 1 (HYPT1) [MIM:605389]: A rare form of non-syndromic hereditary hypotrichosis without characteristic hair shaft anomalies. Affected individuals typically show normal hair at birth, but hair loss and thinning of the hair shaft start during early childhood and progress with age. HYPT1 inheritance is autosomal dominant. {ECO:0000269|PubMed:20393562}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin. May act via its interaction with Wnt and LRP proteins. May play a role in colorectal tumorigenesis. {ECO:0000269|PubMed:12384519, ECO:0000269|PubMed:20393562}.
uniprot
proteins
mass_dalton
58797
uniprot
proteins
post_translational_modification
PTM: N-Glycosylated. {ECO:0000269|PubMed:20393562}.
uniprot
proteins
protein_family
APCDD1 family
uniprot
proteins
pubmed
12384519
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
20393562
uniprot
proteins
sequence_length
514
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20393562}; Single-pass type I membrane protein {ECO:0000269|PubMed:20393562}.
uniprot
proteins
transmembrane_region
TRANSMEM 493..512; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins