Kw 0656
cv_term_accession
KW-0656
canonical
uniprot_keyword
KW-0656
canonical
name
Proto-oncogene
uniprot
definition
Protein whose normal cellular gene can be converted into a cancer- promoting oncogene by activating mutations, chromosomal translocation or DNA amplification. Once activated a proto-oncogene can promote cell transformation in culture or tumorigenesis in animals. Examples include the regulatory GTPase HRAS, which is commonly activated by dominant gain of function point mutations, and the transcription factor MYC, which can be activated by both chromosomal amplification and chromosomal translocation.
uniprot
keywords
is_obsolete
false
uniprot
keywords
ontology_id
uniprot_keywords
uniprot
keywords