Myo1c
entrez
65261
canonical
uniprot
Q63355
canonical
ensembl
ENSRNOG00000004072
resolver
ensp
ENSRNOP00000028929
resolver
ensp
ENSRNOP00000080420
resolver
ensp
ENSRNOP00000096158
resolver
ensp
ENSRNOP00000097261
resolver
ensp
ENSRNOP00000102184
resolver
enst
ENSRNOT00000036666
resolver
enst
ENSRNOT00000101210
resolver
enst
ENSRNOT00000117022
resolver
genesymbol
Myo1c
resolver
genesymbol_syn
Myr2
resolver
uniprot
A0A8I6AQB5
resolver
uniprot
A0A8I6ASB9
resolver
uniprot
A0A8L2QFL2
resolver
uniprot_entry
A0A8I6AQB5_RAT
resolver
uniprot_entry
A0A8I6ASB9_RAT
resolver
uniprot_entry
A0A8L2QFL2_RAT
resolver
uniprot_entry
MYO1C_RAT
resolver
amino_acid_sequence
MRYRASALGSDGVRVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYTRQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFHVFYQLLEGGEEEALRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALSVIDFTEDEVEDLLSIVASVLHLGNIHFAADEDSNAQVTTENQLKYLTRLLGVEGTTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVRKINRSLASKDAESPSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTIKHHPHFLTHKLADQKTRKSLDRGEFRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSTNPIMAQCFDKSELSDKKRPETVATQFKMSLLQLVEILRSKEPAYIRCIKPNDAKQPGRFDEVLIRHQVKYLGLMENLRVRRAGFAYRRKYEAFLQRYKSLCPETWPVWTGRPQDGVAVLVRHLGYKPEEYKMGRTKIFIRFPKTLFATEDSLEVRRQSLATKIQAAWRGFHWRQKFLRVKRSAICIQSWWRGTLGRRKAAKRKWAAQTIRRLIRGFILRHAPRCPENAFFLDHVRTSFLLNLRRQLPRNVLDTSWPTPPPALREASELLRELCMKNMVWKYCRSISPEWKQQLQQKAVASEIFKGKKDNYPQSVPRLFISTRLGTEEISPRVLQALGSEPIQYAVPVVKYDRKGYKPRSRQLLLTPSAVVIVEDAKVKQRIDYANLTGISVSSLSDSLFVLHVQREDSKQKGDVVLQSDHVIETLTKTALSADRVNNININQGSITFAGGPGRDGIIDFTSGSELLITKAKNGHLAVVAPRLNSR
uniprot
proteins
function
FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes (By similarity). {ECO:0000250|UniProtKB:Q9WTI7, ECO:0000269|PubMed:22918957}.
uniprot
proteins
mass_dalton
119811
uniprot
proteins
protein_family
Myosin family
uniprot
proteins
protein_family
TRAFAC class myosin-kinesin ATPase superfamily
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
22918957
uniprot
proteins
sequence_length
1044
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O00159}. Nucleus {ECO:0000250|UniProtKB:O00159}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q9WTI7}. Cell projection, stereocilium membrane {ECO:0000250|UniProtKB:Q92002}. Cytoplasmic vesicle {ECO:0000269|PubMed:22918957}. Cell projection, ruffle membrane {ECO:0000269|PubMed:22918957}. Note=Colocalizes with CABP1 and CIB1 at cell margin, membrane ruffles and punctate regions on the cell membrane (By similarity). Colocalizes in adipocytes with GLUT4 at actin-based membranes (By similarity). Colocalizes with GLUT4 at insulin-induced ruffles at the cell membrane (PubMed:22918957). Localizes transiently at cell membrane to region known to be enriched in PIP2 (By similarity). Activation of phospholipase C results in its redistribution to the cytoplasm (By similarity). Colocalizes with RNA polymerase II (By similarity). Translocates to nuclear speckles upon exposure to inhibitors of RNA polymerase II transcription (By similarity). {ECO:0000250|UniProtKB:O00159, ECO:0000250|UniProtKB:Q9WTI7, ECO:0000269|PubMed:22918957}.
uniprot
proteins