CRHBP
entrez
1393
canonical
uniprot
P24387
canonical
ensembl
ENSG00000145708
resolver
ensp
ENSP00000274368
resolver
ensp
ENSP00000580015
resolver
enst
ENST00000274368
resolver
enst
ENST00000909956
resolver
genesymbol
CRHBP
resolver
genesymbol_syn
CRFBP
resolver
hgnc
HGNC:2356
resolver
uniprot
Q53F32
resolver
uniprot
Q6FHT5
resolver
uniprot_entry
CRHBP_HUMAN
resolver
uniprot_sec
Q53F32
resolver
uniprot_sec
Q6FHT5
resolver
amino_acid_sequence
MSPNFKLQCHFILIFLTALRGESRYLELREAADYDPFLLFSANLKRELAGEQPYRRALRCLDMLSLQGQFTFTADRPQLHCAAFFISEPEEFITIHYDQVSIDCQGGDFLKVFDGWILKGEKFPSSQDHPLPSAERYIDFCESGLSRRSIRSSQNVAMIFFRVHEPGNGFTLTIKTDPNLFPCNVISQTPNGKFTLVVPHQHRNCSFSIIYPVVIKISDLTLGHVNGLQLKKSSAGCEGIGDFVELLGGTGLDPSKMTPLADLCYPFHGPAQMKVGCDNTVVRMVSSGKHVNRVTFEYRQLEPYELENPNGNSIGEFCLSGL
uniprot
proteins
function
FUNCTION: Specifically binds and inactivates the corticotropin-releasing hormone (CRH) and urocortin-1 (UCN) hormones, thereby inhibiting the hypothalamus-pituitary-adrenal axis and preventing corticotropin hormone (ACTH) production (PubMed:18234674, PubMed:1846945, PubMed:3494446, PubMed:7477348, PubMed:7585095). May be required to prevent inappropriate pituitary-adrenal stimulation in pregnancy (PubMed:7585095). {ECO:0000269|PubMed:18234674, ECO:0000269|PubMed:1846945, ECO:0000269|PubMed:3494446, ECO:0000269|PubMed:7477348, ECO:0000269|PubMed:7585095}.
uniprot
proteins
mass_dalton
36144
uniprot
proteins
mutagenesis
MUTAGEN 56; /note="R->A: Abolishes binding to CRH without affecting affinity to UCN."; /evidence="ECO:0000269|PubMed:18234674"; MUTAGEN 61; /note="L->A: Decreased binding to CRH without affecting affinity to UCN."; /evidence="ECO:0000269|PubMed:18234674"; MUTAGEN 62; /note="D->A: Abolishes binding to CRH without affecting affinity to UCN."; /evidence="ECO:0000269|PubMed:18234674"; MUTAGEN 116; /note="W->A: Abolishes binding to CRH aand UCN."; /evidence="ECO:0000269|PubMed:18234674"; MUTAGEN 121; /note="E->A: Decreased binding to CRH without affecting affinity to UCN."; /evidence="ECO:0000269|PubMed:18234674"; MUTAGEN 123; /note="F->A: Decreased binding to CRH without affecting affinity to UCN."; /evidence="ECO:0000269|PubMed:18234674"; MUTAGEN 188; /note="Q->A: Decreased binding to CRH without affecting affinity to UCN."; /evidence="ECO:0000269|PubMed:18234674"; MUTAGEN 204; /note="N->A: Abolished N-glycosylation."; /evidence="ECO:0000269|PubMed:18234674"; MUTAGEN 211; /note="Y->A: Abolishes binding to CRH without affecting affinity to UCN."; /evidence="ECO:0000269|PubMed:18234674
uniprot
proteins
protein_family
CRF-binding protein family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18234674
uniprot
proteins
pubmed
1846945
uniprot
proteins
pubmed
18559919
uniprot
proteins
pubmed
3494446
uniprot
proteins
pubmed
7477348
uniprot
proteins
pubmed
7585095
uniprot
proteins
pubmed
8198617
uniprot
proteins
pubmed
8307998
uniprot
proteins
sequence_length
322
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1846945, ECO:0000269|PubMed:18559919, ECO:0000269|PubMed:3494446}.
uniprot
proteins