Gabrg2
entrez
29709
canonical
uniprot
P18508
canonical
ensembl
ENSRNOG00000003241
resolver
ensembl
ENSRNOG00055003048
resolver
ensembl
ENSRNOG00060019761
resolver
ensembl
ENSRNOG00065001340
resolver
ensp
ENSRNOP00000004619
resolver
ensp
ENSRNOP00000072234
resolver
ensp
ENSRNOP00055003524
resolver
ensp
ENSRNOP00060027994
resolver
ensp
ENSRNOP00065001233
resolver
enst
ENSRNOT00000004619
resolver
enst
ENSRNOT00000082445
resolver
enst
ENSRNOT00055004755
resolver
enst
ENSRNOT00060034154
resolver
enst
ENSRNOT00065001774
resolver
genesymbol
Gabrg2
resolver
uniprot
A0A0G2K2G4
resolver
uniprot
Q6PW52
resolver
uniprot_entry
A0A0G2K2G4_RAT
resolver
uniprot_entry
GBRG2_RAT
resolver
uniprot_entry
Q6PW52_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Allosterically activated by benzodiazepines (By similarity). Activated by pentobarbital (PubMed:2561970). Inhibited by the antagonist bicuculline (PubMed:2561970). Inhibited by zinc ions (By similarity). Potentiated by histamine (By similarity). {ECO:0000250|UniProtKB:P18507, ECO:0000250|UniProtKB:P22723, ECO:0000269|PubMed:2561970}.
uniprot
proteins
amino_acid_sequence
MSSPNTWSTGSTVYSPVFSQKMTLWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPKVPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDKKKKNPAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL
uniprot
proteins
function
FUNCTION: Gamma subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:2561970, PubMed:30044221). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (PubMed:30044221). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:2561970, PubMed:30044221). Gamma-2/GABRG2-containing GABAARs are found at both synaptic and extrasynaptic sites (PubMed:9464994). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). GABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (By similarity). Extrasynaptic gamma-2-containing receptors contribute to the tonic GABAergic inhibition (PubMed:9464994). GABAARs function also as histamine receptor where histamine binds at the interface of two neighboring beta subunits and potentiates GABA response in a gamma-2 subunit-controlled manner (By similarity). {ECO:0000250|UniProtKB:P08219, ECO:0000250|UniProtKB:P18507, ECO:0000250|UniProtKB:P22723, ECO:0000269|PubMed:2561970, ECO:0000269|PubMed:30044221, ECO:0000269|PubMed:9464994}.
uniprot
proteins
mass_dalton
54077
uniprot
proteins
post_translational_modification
PTM: Palmitoylated by ZDHHC3/GODZ; required for the accumulation of GABA(A) receptors at the postsynaptic membrane of inhibitory GABAergic synapses. {ECO:0000250|UniProtKB:P22723}.; PTM: Glycosylated. {ECO:0000250|UniProtKB:P22723}.
uniprot
proteins
protein_family
GABRG2 sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
17003036
uniprot
proteins
pubmed
2165521
uniprot
proteins
pubmed
25172774
uniprot
proteins
pubmed
2561970
uniprot
proteins
pubmed
28279354
uniprot
proteins
pubmed
30044221
uniprot
proteins
pubmed
9464994
uniprot
proteins
sequence_length
466
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000269|PubMed:2561970, ECO:0000269|PubMed:9464994}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P18507}. Cell membrane {ECO:0000269|PubMed:2561970, ECO:0000269|PubMed:9464994}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P18507}. Cell projection, dendrite {ECO:0000250|UniProtKB:P22723}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:25172774}. Note=The gamma-2 subunits are present in Golgi synapses and on the extrasynaptic membranes (when associated with alpha-1/6 and beta-2/3 subunits), and in some of the mossy fiber to granule cell synapses (when associated with alpha-6 and beta-2/3 subunits). Present in GABAergic and glutamatergic synapses on granule cells. {ECO:0000269|PubMed:9464994}.
uniprot
proteins
transmembrane_region
TRANSMEM 275..295; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P18507"; TRANSMEM 302..321; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P18507"; TRANSMEM 334..358; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P18507"; TRANSMEM 443..463; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P18507
uniprot
proteins