Plaur
entrez
50692
canonical
uniprot
P49616
canonical
ensembl
ENSRNOG00000037931
resolver
ensembl
ENSRNOG00055032435
resolver
ensembl
ENSRNOG00060033011
resolver
ensembl
ENSRNOG00065033571
resolver
ensp
ENSRNOP00000065210
resolver
genesymbol
Plaur
resolver
uniprot
O35771
resolver
uniprot
P51573
resolver
uniprot
Q7TN35
resolver
uniprot_entry
UPAR_RAT
resolver
uniprot_sec
O35771
resolver
uniprot_sec
P51573
resolver
uniprot_sec
Q7TN35
resolver
activity_regulation
ACTIVITY REGULATION: Cleavage of the GPI anchor by GDPD2 inactivates receptor functions in vitronectin-mediated cell-matrix adhesion and plasmin-dependent extracellular matrix remodeling. {ECO:0000250|UniProtKB:Q03405}.
uniprot
proteins
amino_acid_sequence
MGLLRRRLLLLVVVVTTCVPASQGLRCIQCESNQDCLVEECALGQDLCRTTVLREWEDAEELEVVTRGCAHKEKTNRTMSYRMGSVIVSLTETVCATNLCNRPRPGARGRPFPRGRYLECASCTSLDQSCERGREQSLQCRYPTEHCIEVVTLQSTERSVKDEPYTKGCGSLPGCPGTAGFHSNQTFHFLKCCNFTQCNGGPVLDLQSLPPNGFQCYSCEGNSTFGCSYEETSLIDCRGPMNQCLEATGLDVLGNRSYTVRGCATASWCQGSHVADSFQTHVNLSISCCNGSGCNRPTGGAPGPGPAHLILIASLLLTLRLWGIPLWT
uniprot
proteins
function
FUNCTION: GPI-anchored receptor that recruits and activates the urokinase-type plasminogen activator (uPA) at the cell surface. Activated uPA converts plasminogen into plasmin, initiating extracellular matrix degradation and remodeling. Also binds the extracellular matrix protein vitronectin, promoting cell-matrix adhesion and indirectly integrin signaling. This dual interaction coordinates dynamic changes in cell migration, proliferation, and tissue remodeling. {ECO:0000250|UniProtKB:Q03405}.
uniprot
proteins
mass_dalton
35753
uniprot
proteins
post_translational_modification
PTM: Attached to the external leaflet of the plasma membrane via a GPI anchor. The GPI anchor can be cleaved by a phospholipase, releasing the protein from membranes. {ECO:0000250|UniProtKB:Q03405}.
uniprot
proteins
pubmed
1321734
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8307160
uniprot
proteins
sequence_length
328
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:1321734}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q03405}. Cell projection, invadopodium membrane {ECO:0000250|UniProtKB:Q03405}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q03405}. Note=Colocalized with FAP (seprase) preferentially at the cell surface of invadopodia membrane in a cytoskeleton-, integrin- and vitronectin-dependent manner. {ECO:0000250|UniProtKB:Q03405}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305|PubMed:8307160}.
uniprot
proteins