Iigp1
entrez
60440
canonical
uniprot
Q9QZ85
canonical
ensembl
ENSMUSG00000054072
resolver
ensp
ENSMUSP00000032473
resolver
ensp
ENSMUSP00000063390
resolver
ensp
ENSMUSP00000157568
resolver
ensp
ENSMUSP00000160353
resolver
ensp
ENSMUSP00000160354
resolver
ensp
ENSMUSP00000160355
resolver
enst
ENSMUST00000032473
resolver
enst
ENSMUST00000066912
resolver
enst
ENSMUST00000237185
resolver
genesymbol
Iigp1
resolver
genesymbol_syn
Ifgga1
resolver
genesymbol_syn
Irga6
resolver
uniprot
J7NNX8
resolver
uniprot
Q9Z1M3
resolver
uniprot_entry
IIGP1_MOUSE
resolver
uniprot_entry
J7NNX8_MOUSE
resolver
uniprot_sec
Q9Z1M3
resolver
amino_acid_sequence
MGQLFSSPKSDENNDLPSSFTGYFKKFNTGRKIISQEILNLIELRMRKGNIQLTNSAISDALKEIDSSVLNVAVTGETGSGKSSFINTLRGIGNEEEGAAKTGVVEVTMERHPYKHPNIPNVVFWDLPGIGSTNFPPNTYLEKMKFYEYDFFIIISATRFKKNDIDIAKAISMMKKEFYFVRTKVDSDITNEADGKPQTFDKEKVLQDIRLNCVNTFRENGIAEPPIFLLSNKNVCHYDFPVLMDKLISDLPIYKRHNFMVSLPNITDSVIEKKRQFLKQRIWLEGFAADLVNIIPSLTFLLDSDLETLKKSMKFYRTVFGVDETSLQRLARDWEIEVDQVEAMIKSPAVFKPTDEETIQERLSRYIQEFCLANGYLLPKNSFLKEIFYLKYYFLDMVTEDAKTLLKEICLRN
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: GTPase with low activity (PubMed:12732635). Has higher affinity for GDP than for GTP (PubMed:12732635). Plays a role in resistance to intracellular pathogens (PubMed:11907101). During infection with avirulent Toxoplasma gondii strains, recruited to the parasitophorous vacuole membrane (PubMed:24324375, PubMed:24390541, PubMed:22802726, PubMed:21203588). Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite (PubMed:16304607). Mediates resistance to Chlamydia trachomatis infection by targeting bacterial inclusions to autophagosomes for subsequent lysosomal destruction (PubMed:19242543). {ECO:0000269|PubMed:11907101, ECO:0000269|PubMed:12732635, ECO:0000269|PubMed:16304607, ECO:0000269|PubMed:19242543, ECO:0000269|PubMed:21203588, ECO:0000269|PubMed:22802726, ECO:0000269|PubMed:24324375, ECO:0000269|PubMed:24390541}.
uniprot
proteins
mass_dalton
47572
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="G->A: Protein is detected exclusively in the aqueous phase."; /evidence="ECO:0000269|PubMed:15294976"; MUTAGEN 82; /note="K->A: Constitutively active. Binds GTP but fails to hydrolyze it. Does not localize to the parasitophorous vacuole membrane following T.gondii infection."; /evidence="ECO:0000269|PubMed:16304607, ECO:0000269|PubMed:18772884"; MUTAGEN 83; /note="S->N: Abrogates interaction with HOOK3. Greatly reduces binding affinity for GDP and GTP. Abolishes GTP-dependent oligomer formation."; /evidence="ECO:0000269|PubMed:15075236, ECO:0000269|PubMed:18772884"; MUTAGEN 102; /note="T->A: Abolishes interaction with T.gondii GRA7. Abolishes GTPase activity. Reduces GTP-dependent oligomerization."; /evidence="ECO:0000269|PubMed:21203588, ECO:0000269|PubMed:24390541"; MUTAGEN 102; /note="T->D: Abolishes GTPase activity. Reduces GTP-dependent oligomerization. Results in inefficient accumulation of protein at parasitophorous vacuole following infection with avirulent T.gondii strain; reduces accumulation of wild-type protein."; /evidence="ECO:0000269|PubMed:21203588"; MUTAGEN 108; /note="T->A: Abolishes interaction with T.gondii GRA7. Abolishes GTPase activity. Reduces GTP-dependent oligomerization."; /evidence="ECO:0000269|PubMed:21203588, ECO:0000269|PubMed:24390541"; MUTAGEN 108; /note="T->D: Abolishes GTPase activity. Reduces GTP-dependent oligomerization. Results in inefficient accumulation of protein at parasitophorous vacuole following infection with avirulent T.gondii strain; reduces accumulation of wild-type protein."; /evidence="ECO:0000269|PubMed:21203588"; MUTAGEN 161; /note="K->E: Blocks T.gondii ROP5 binding."; /evidence="ECO:0000269|PubMed:22802726"; MUTAGEN 162; /note="K->E: Blocks T.gondii ROP5 binding."; /evidence="ECO:0000269|PubMed:22802726"; MUTAGEN 164; /note="D->A: Blocks T.gondii ROP5 binding."; /evidence="ECO:0000269|PubMed:22802726"; MUTAGEN 196; /note="K->D: Blocks T.gondii ROP5 binding."; /evidence="ECO:0000269|PubMed:22802726"; MUTAGEN 197; /note="P->H: Blocks T.gondii ROP5 binding."; /evidence="ECO:0000269|PubMed:22802726"; MUTAGEN 212; /note="N->R: Blocks T.gondii ROP5 binding."; /evidence="ECO:0000269|PubMed:22802726"; MUTAGEN 213; /note="C->R: Blocks T.gondii ROP5 binding."; /evidence="ECO:0000269|PubMed:22802726
uniprot
proteins
post_translational_modification
PTM: Myristoylated. {ECO:0000269|PubMed:21203588}.; PTM: (Microbial infection) Phosphorylated by Toxoplasma gondii ROP18 from virulent strains. {ECO:0000269|PubMed:21147463, ECO:0000269|PubMed:21203588, ECO:0000269|PubMed:22802726}.
uniprot
proteins
protein_family
IRG family
uniprot
proteins
protein_family
TRAFAC class dynamin-like GTPase superfamily
uniprot
proteins
pubmed
11907101
uniprot
proteins
pubmed
12732635
uniprot
proteins
pubmed
15075236
uniprot
proteins
pubmed
15294976
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16304607
uniprot
proteins
pubmed
18772884
uniprot
proteins
pubmed
18784077
uniprot
proteins
pubmed
19242543
uniprot
proteins
pubmed
21147463
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21203588
uniprot
proteins
pubmed
22761577
uniprot
proteins
pubmed
22802726
uniprot
proteins
pubmed
24324375
uniprot
proteins
pubmed
24390541
uniprot
proteins
pubmed
25118287
uniprot
proteins
pubmed
26158675
uniprot
proteins
pubmed
9862701
uniprot
proteins
sequence_length
413
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Parasitophorous vacuole membrane. Note=Localizes to the bacterial inclusions formed following C.trachomatis infection. Accumulates in a GTP-bound form on the parasitophorous vacuole membranes formed following T.gondii infection but exists in a GDP-bound form in uninfected cells.; SUBCELLULAR LOCATION: Parasitophorous vacuole membrane; Peripheral membrane protein {ECO:0000269|PubMed:24324375, ECO:0000269|PubMed:24390541}. Note=(Microbial infection).
uniprot
proteins