Nelfe
entrez
27632
canonical
uniprot
P19426
canonical
ensembl
ENSMUSG00000024369
resolver
ensp
ENSMUSP00000094956
resolver
ensp
ENSMUSP00000131195
resolver
ensp
ENSMUSP00000134272
resolver
genesymbol
Nelfe
resolver
genesymbol_syn
D17h6s45
resolver
genesymbol_syn
Rd
resolver
genesymbol_syn
Rdbp
resolver
uniprot
P97485
resolver
uniprot
P97486
resolver
uniprot
Q3UIA1
resolver
uniprot
Q9CZN3
resolver
uniprot_entry
NELFE_MOUSE
resolver
uniprot_entry
Q3UIA1_MOUSE
resolver
uniprot_sec
P97485
resolver
uniprot_sec
P97486
resolver
uniprot_sec
Q9CZN3
resolver
amino_acid_sequence
MLVIPPGLSEEEEALQKKFNKLKKKKKALLALKKQSSSGPASQGGVKRSLSEQPVVDTATATEQAKQLVKSGAISAIKAETKNSGFKRSRTLEGKLKDPEKGPVPTFQPFQRSMSADEDLQEPSRRPQRKSLYESFVSSSDRLRELGQDGEEAEAPGAGDGPPRGFDWSYEEHGSARSSASPPRSRSRDRSHDRSRDRDRDKERDRDRDRDRDRDRDKDKDRDRDRDRDKERDRDRDRDRDRERDREGPFRRSDSFPERRAPRKGNTLYVYGEDMTPTLLRGAFSPFGNIIDLSMDPPRNCAFVTYEKMESADQAVAELNGTQVESVQLKVNIARKQPMLDAATGKSVWGSLAVQNSPKGCHRDKRTQIVYSDDL
uniprot
proteins
function
FUNCTION: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:31399344). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:31399344). Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA (By similarity). {ECO:0000250|UniProtKB:P18615, ECO:0000269|PubMed:31399344}.
uniprot
proteins
mass_dalton
42554
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by the P-TEFb complex at sites next to its RNA recognition motif, promoting its release from chromatin. {ECO:0000269|PubMed:31399344}.; PTM: Sumoylated. {ECO:0000250|UniProtKB:P18615}.; PTM: Poly-ADP-ribosylated by PARP1, thereby preventing RNA-binding and relieving transcription pausing. {ECO:0000250|UniProtKB:P18615}.
uniprot
proteins
protein_family
RRM NELF-E family
uniprot
proteins
pubmed
14656967
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26010750
uniprot
proteins
pubmed
31399344
uniprot
proteins
pubmed
3353717
uniprot
proteins
pubmed
9321489
uniprot
proteins
sequence_length
375
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31399344}. Chromosome {ECO:0000269|PubMed:31399344}. Note=Localizes to chromatin (PubMed:31399344). Phosphorylation by the P-TEFb complex promotes its release from chromatin (PubMed:31399344). {ECO:0000269|PubMed:31399344}.
uniprot
proteins