NGEF
entrez
25791
canonical
uniprot
Q8N5V2
canonical
ensembl
ENSG00000066248
resolver
ensp
ENSP00000264051
resolver
ensp
ENSP00000362653
resolver
ensp
ENSP00000575082
resolver
genesymbol
NGEF
resolver
hgnc
HGNC:7807
resolver
uniprot
B4DDI2
resolver
uniprot
B4DMB8
resolver
uniprot
B9A045
resolver
uniprot
E9PC42
resolver
uniprot
Q53QQ4
resolver
uniprot
Q53ST7
resolver
uniprot
Q6GMQ5
resolver
uniprot
Q9NQD6
resolver
uniprot_entry
B4DDI2_HUMAN
resolver
uniprot_entry
NGEF_HUMAN
resolver
uniprot_sec
B4DMB8
resolver
uniprot_sec
B9A045
resolver
uniprot_sec
E9PC42
resolver
uniprot_sec
Q53QQ4
resolver
uniprot_sec
Q53ST7
resolver
uniprot_sec
Q6GMQ5
resolver
uniprot_sec
Q9NQD6
resolver
amino_acid_sequence
METRESEDLEKTRRKSASDQWNTDNEPAKVKPELLPEKEETSQADQDIQDKEPHCHIPIKRNSIFNRSIRRKSKAKARDNPERNASCLADSQDNGKSVNEPLTLNIPWSRMPPCRTAMQTDPGAQEMSESSSTPGNGATPEEWPALADSPTTLTEALRMIHPIPADSWRNLIEQIGLLYQEYRDKSTLQEIETRRQQDAEIEDNTNGSPASEDTPEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRKILHPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTALDAHKELEMVVKACNEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSGPKTSRTLRTKKLFHEIYLFLFNDLLVICRQIPGDKYQVFDSAPRGLLRVEELEDQGQTLANVFILRLLENADDREATYMLKASSQSEMKRWMTSLAPNRRTKFVSFTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKTDDGWIFGERLHDQERGWFPSSMTEEILNPKIRSQNLKECFRVHKMDDPQRSQNKDRRKLGSRNRQ
uniprot
proteins
function
FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
82496
uniprot
proteins
post_translational_modification
PTM: Src-dependent phosphorylation at Tyr-179 upon EPHA4 activation increases the guanine exchange factor activity toward RHOA. Phosphorylation by CDK5 upon EPHA4 activation by EFNA1 may regulate dendritic spine morphogenesis (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
10777665
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
710
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Note=Associated with membranes. Localizes to axonal growth cones (By similarity). {ECO:0000250}.
uniprot
proteins