NR1I2
entrez
8856
canonical
uniprot
O75469
canonical
ensembl
ENSG00000144852
resolver
ensp
ENSP00000336528
resolver
ensp
ENSP00000377319
resolver
ensp
ENSP00000420297
resolver
genesymbol
NR1I2
resolver
genesymbol
NR1i2
resolver
genesymbol_syn
NR1I2
resolver
genesymbol_syn
PXR
resolver
hgnc
HGNC:7968
resolver
uniprot
F1D8P9
resolver
uniprot
Q006P5
resolver
uniprot
Q008C8
resolver
uniprot
Q96AC7
resolver
uniprot
Q9UJ22
resolver
uniprot
Q9UJ23
resolver
uniprot
Q9UJ24
resolver
uniprot
Q9UJ25
resolver
uniprot
Q9UJ26
resolver
uniprot
Q9UJ27
resolver
uniprot
Q9UNW4
resolver
uniprot_entry
F1D8P9_HUMAN
resolver
uniprot_entry
NR1I2_HUMAN
resolver
uniprot_sec
Q006P5
resolver
uniprot_sec
Q008C8
resolver
uniprot_sec
Q96AC7
resolver
uniprot_sec
Q9UJ22
resolver
uniprot_sec
Q9UJ23
resolver
uniprot_sec
Q9UJ24
resolver
uniprot_sec
Q9UJ25
resolver
uniprot_sec
Q9UJ26
resolver
uniprot_sec
Q9UJ27
resolver
uniprot_sec
Q9UNW4
resolver
amino_acid_sequence
MEVRPKESWNHADFVHCEDTESVPGKPSVNADEEVGGPQICRVCGDKATGYHFNVMTCEGCKGFFRRAMKRNARLRCPFRKGACEITRKTRRQCQACRLRKCLESGMKKEMIMSDEAVEERRALIKRKKSERTGTQPLGVQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVLSSGCELPESLQAPSREEAAKWSQVRKDLCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPFATPLMQELFGITGS
uniprot
proteins
function
FUNCTION: Nuclear receptor that acts as a transcription factor regulating genes involved in the metabolism and excretion of xenobiotics, drugs, and endogenous compounds. Activated by a broad range of endogenous steroids (e.g. pregnenolone, progesterone) and xenobiotics, including the antibiotic rifampicin and certain plant-derived metabolites. Upon ligand binding, translocates to the nucleus, forms a heterodimer with the retinoid X receptor/RXR, and binds to response elements in target promoters, leading to transcriptional activation. Target genes include cytochrome P450 enzymes such as CYP3A4 and ATP-binding cassette transporters including ABCB1/MDR1. {ECO:0000269|PubMed:11297522, ECO:0000269|PubMed:11668216, ECO:0000269|PubMed:12578355, ECO:0000269|PubMed:18768384, ECO:0000269|PubMed:19297428, ECO:0000269|PubMed:26534988, ECO:0000269|PubMed:9727070}.
uniprot
proteins
mass_dalton
49762
uniprot
proteins
mutagenesis
MUTAGEN 66..67; /note="RR->AA: Abolishes nuclear localization; when associated with 91-A-A-92."; /evidence="ECO:0000269|PubMed:12606758"; MUTAGEN 91..92; /note="RR->AA: Abolishes nuclear localization; when associated with 66-A-A-67."; /evidence="ECO:0000269|PubMed:12606758"; MUTAGEN 408; /note="T->D: Reduced transcriptional activity and protein stability."; /evidence="ECO:0000269|PubMed:26534988
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKC at Thr-408. {ECO:0000269|PubMed:26534988}.; PTM: Ubiquitinated by RBCK1, leading to proteasomal degradation (PubMed:23160820). Ubiquitinated in a FBXO44-dependent manner also leads to proteasomal degradation (PubMed:37969738). {ECO:0000269|PubMed:23160820, ECO:0000269|PubMed:37969738}.
uniprot
proteins
protein_family
NR1 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
11297522
uniprot
proteins
pubmed
11408620
uniprot
proteins
pubmed
11668216
uniprot
proteins
pubmed
12578355
uniprot
proteins
pubmed
12606758
uniprot
proteins
pubmed
12909012
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15618712
uniprot
proteins
pubmed
15705662
uniprot
proteins
pubmed
17215127
uniprot
proteins
pubmed
18768384
uniprot
proteins
pubmed
19297428
uniprot
proteins
pubmed
23160820
uniprot
proteins
pubmed
26534988
uniprot
proteins
pubmed
37969738
uniprot
proteins
pubmed
9727070
uniprot
proteins
pubmed
9770465
uniprot
proteins
pubmed
9784494
uniprot
proteins
sequence_length
434
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:12606758, ECO:0000269|PubMed:26534988}. Cytoplasm {ECO:0000269|PubMed:26534988}.
uniprot
proteins