Pqbp1
entrez
54633
canonical
uniprot
Q91VJ5
canonical
ensembl
ENSMUSG00000031157
resolver
ensp
ENSMUSP00000033497
resolver
ensp
ENSMUSP00000111318
resolver
ensp
ENSMUSP00000111319
resolver
ensp
ENSMUSP00000123657
resolver
enst
ENSMUST00000033497
resolver
enst
ENSMUST00000115654
resolver
enst
ENSMUST00000115655
resolver
genesymbol
Pqbp1
resolver
genesymbol_syn
Npw38
resolver
uniprot
A2AER7
resolver
uniprot
Q80WW2
resolver
uniprot
Q9ER43
resolver
uniprot
Q9QYY2
resolver
uniprot_entry
A2AER7_MOUSE
resolver
uniprot_entry
PQBP1_MOUSE
resolver
uniprot_sec
Q80WW2
resolver
uniprot_sec
Q9ER43
resolver
uniprot_sec
Q9QYY2
resolver
amino_acid_sequence
MPLPVALQTRLAKRGILKHLEPEPEEEIIAEDYDDDPVDYEATRIEGLPPSWYKVFDPSCGLPYYWNVETDLVSWLSPHDPNFVVTKSAKKVRNNNADAEDKSDRNLEKVDRNHEKSDRSHEKPDRSHEKADRNHEKNDRERERNYDKVDRERDRDRERERAFDKADREEGKDRRHHRREELAPYPKNKKATSRKDEELDPMDPSSYSDAPRGTWSTGLPKRNEAKTGADTTAAGPLFQQRPYPSPGAVLRANAEASRTKQQD
uniprot
proteins
function
FUNCTION: Intrinsically disordered protein that acts as a scaffold, and which is involved in different processes, such as pre-mRNA splicing, transcription regulation, innate immunity and neuron development (By similarity). Interacts with splicing-related factors via the intrinsically disordered region and regulates alternative splicing of target pre-mRNA species (PubMed:23512658). May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner (By similarity). Can activate transcription directly or via association with the transcription machinery (By similarity). May be involved in ATXN1 mutant-induced cell death (By similarity). The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit (By similarity). Involved in the assembly of cytoplasmic stress granule, possibly by participating in the transport of neuronal RNA granules (By similarity). Also acts as an innate immune sensor of infection by retroviruses, by detecting the presence of reverse-transcribed DNA in the cytosol (By similarity). Directly binds retroviral reverse-transcribed DNA in the cytosol and interacts with CGAS, leading to activate the cGAS-STING signaling pathway, triggering type-I interferon production (By similarity). {ECO:0000250|UniProtKB:O60828, ECO:0000269|PubMed:23512658}.
uniprot
proteins
mass_dalton
30597
uniprot
proteins
pubmed
10332029
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23512658
uniprot
proteins
sequence_length
263
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23512658}. Nucleus speckle {ECO:0000269|PubMed:23512658}. Cytoplasmic granule {ECO:0000250|UniProtKB:O60828}. Note=Colocalizes with SRSF2 in nuclear speckles (PubMed:23512658). Colocalized with POU3F2. Colocalized with ATXN1 in nuclear inclusion bodies. Localizes to cytoplasmic stress granules (By similarity). {ECO:0000250|UniProtKB:O60828, ECO:0000269|PubMed:23512658}.
uniprot
proteins