Pla2g1b
entrez
29526
canonical
uniprot
P04055
canonical
ensembl
ENSRNOG00000001153
resolver
ensp
ENSRNOP00000001525
resolver
enst
ENSRNOT00000001525
resolver
genesymbol
Pla2g1b
resolver
uniprot
A0A8L2PYZ4
resolver
uniprot_entry
A0A8L2PYZ4_RAT
resolver
uniprot_entry
PA21B_RAT
resolver
amino_acid_sequence
MKLLLLAALLTAGVTAHSISTRAVWQFRNMIKCTIPGSDPLREYNNYGCYCGLGGSGTPVDDLDRCCQTHDHCYNQAKKLESCKFLIDNPYTNTYSYKCSGNVITCSDKNNDCESFICNCDRQAAICFSKVPYNKEYKDLDTKKHC
uniprot
proteins
ec_number
3.1.1.4
uniprot
proteins
function
FUNCTION: Secretory calcium-dependent phospholipase A2 that primarily targets dietary phospholipids in the intestinal tract (PubMed:1420353, PubMed:17158102). Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) with preference for phosphatidylethanolamines and phosphatidylglycerols over phosphatidylcholines (PubMed:1420353, PubMed:17158102). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism and inflammation in the intestinal tract (PubMed:14998370). Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (PubMed:14998370). May act in an autocrine and paracrine manner (By similarity). Has anti-helminth activity in a process regulated by gut microbiota. Upon helminth infection of intestinal epithelia, directly affects phosphatidylethanolamine contents in the membrane of helminth larvae, likely controlling an array of phospholipid-mediated cellular processes such as membrane fusion and cell division while providing for better immune recognition, ultimately reducing larvae integrity and infectivity (By similarity). {ECO:0000250|UniProtKB:P04054, ECO:0000250|UniProtKB:Q9Z0Y2, ECO:0000269|PubMed:1420353, ECO:0000269|PubMed:14998370, ECO:0000269|PubMed:17158102}.
uniprot
proteins
mass_dalton
16424
uniprot
proteins
post_translational_modification
PTM: Activated by trypsin cleavage in the duodenum. Can also be activated by thrombin or autocatalytically. {ECO:0000250|UniProtKB:P04054}.
uniprot
proteins
protein_family
Phospholipase A2 family
uniprot
proteins
pubmed
1420353
uniprot
proteins
pubmed
14998370
uniprot
proteins
pubmed
17158102
uniprot
proteins
pubmed
2909239
uniprot
proteins
pubmed
3754861
uniprot
proteins
pubmed
6501264
uniprot
proteins
sequence_length
146
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P04054}. Note=Secreted from pancreatic acinar cells in its inactive form. {ECO:0000250|UniProtKB:P04054}.
uniprot
proteins