Csnk1e
entrez
27373
canonical
uniprot
Q9JMK2
canonical
ensembl
ENSMUSG00000022433
resolver
ensp
ENSMUSP00000113096
resolver
ensp
ENSMUSP00000113341
resolver
ensp
ENSMUSP00000113975
resolver
ensp
ENSMUSP00000197113
resolver
ensp
ENSMUSP00000197116
resolver
ensp
ENSMUSP00000197117
resolver
ensp
ENSMUSP00000197118
resolver
ensp
ENSMUSP00000197132
resolver
ensp
ENSMUSP00000197133
resolver
ensp
ENSMUSP00000197134
resolver
ensp
ENSMUSP00000197137
resolver
ensp
ENSMUSP00000197138
resolver
ensp
ENSMUSP00000197139
resolver
ensp
ENSMUSP00000197141
resolver
ensp
ENSMUSP00000197142
resolver
ensp
ENSMUSP00000197146
resolver
ensp
ENSMUSP00000197147
resolver
ensp
ENSMUSP00000334967
resolver
ensp
ENSMUSP00000334968
resolver
ensp
ENSMUSP00000334969
resolver
enst
ENSMUST00000117786
resolver
enst
ENSMUST00000120859
resolver
enst
ENSMUST00000122044
resolver
genesymbol
Csnk1e
resolver
uniprot
F7DF07
resolver
uniprot
Q3TYE1
resolver
uniprot
Q8R389
resolver
uniprot_entry
F7DF07_MOUSE
resolver
uniprot_entry
KC1E_MOUSE
resolver
uniprot_entry
Q3TYE1_MOUSE
resolver
uniprot_sec
Q8R389
resolver
activity_regulation
ACTIVITY REGULATION: Phosphorylation leads to a decrease in the catalytic activity. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARNPEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQQTGNTSPRAISRADRERKVSMRLHRGAPANVSSSDLTGRQEVSRLAASQTSVPFDHLGK
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (By similarity). Participates in Wnt signaling (By similarity). Phosphorylates DVL1 (By similarity). Phosphorylates DVL2 (By similarity). Phosphorylates NEDD9/HEF1 (PubMed:29191835). Central component of the circadian clock (PubMed:18400165, PubMed:19414593, PubMed:21930935). In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:18400165, PubMed:19414593, PubMed:21930935). Controls PER1 and PER2 nuclear transport and degradation (PubMed:10848614, PubMed:14701732, PubMed:18400165, PubMed:19414593, PubMed:21930935). Inhibits cytokine-induced granuloytic differentiation (By similarity). {ECO:0000250|UniProtKB:P49674, ECO:0000269|PubMed:10848614, ECO:0000269|PubMed:14701732, ECO:0000269|PubMed:18400165, ECO:0000269|PubMed:19414593, ECO:0000269|PubMed:21930935, ECO:0000269|PubMed:29191835}.
uniprot
proteins
mass_dalton
47322
uniprot
proteins
mutagenesis
MUTAGEN 38; /note="K->A: Decreases PER1 phosphorylation."; /evidence="ECO:0000269|PubMed:10848614"; MUTAGEN 38; /note="K->R: Increases PER1 nuclear import."; /evidence="ECO:0000269|PubMed:10848614"; MUTAGEN 178; /note="R->C: Shortens circadian rhythm. Accelerates PER2 degradation."; /evidence="ECO:0000269|PubMed:18400165
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. Partially dephosphorylated by PPP5C. May be dephosphorylated by PP1.
uniprot
proteins
protein_family
CK1 Ser/Thr protein kinase family
uniprot
proteins
protein_family
Casein kinase I subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10640823
uniprot
proteins
pubmed
10848614
uniprot
proteins
pubmed
11779462
uniprot
proteins
pubmed
12183362
uniprot
proteins
pubmed
14701732
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
16790549
uniprot
proteins
pubmed
18400165
uniprot
proteins
pubmed
19414593
uniprot
proteins
pubmed
21930935
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
29191835
uniprot
proteins
sequence_length
416
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:19414593}.
uniprot
proteins