Psenen
entrez
292788
canonical
uniprot
Q6QI68
canonical
ensembl
ENSRNOG00000020941
resolver
ensembl
ENSRNOG00055031780
resolver
ensembl
ENSRNOG00060031330
resolver
ensembl
ENSRNOG00065032678
resolver
ensp
ENSRNOP00000028438
resolver
ensp
ENSRNOP00055045431
resolver
ensp
ENSRNOP00060045029
resolver
ensp
ENSRNOP00065046301
resolver
enst
ENSRNOT00000028438
resolver
enst
ENSRNOT00055054984
resolver
enst
ENSRNOT00060054356
resolver
enst
ENSRNOT00065056203
resolver
genesymbol
Psenen
resolver
uniprot_entry
PEN2_RAT
resolver
amino_acid_sequence
MNLERVSNEEKLNLCRKYYLGGFAFLPFLWLVNIFWFFKEAFFAPAYTEQSQIKGYVWRSAVGFLFWVIVLTTWITIFQIYRPRWGALGDYLSFTIPLGTP
uniprot
proteins
function
FUNCTION: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (By similarity). Besides its role in gamma-secretase complex, acts as a regulator of AMP-activated protein kinase (AMPK) activity in response to calorie restriction: binds metformin, an antidiabetic drug, promoting association with ATP6AP1, a subunit of the V-ATPase complex, leading to V-ATPase complex inhibition on lysosomes and AMPK activation via the AXIN1-STK11/LKB1 axis (By similarity). {ECO:0000250|UniProtKB:Q9CQR7, ECO:0000250|UniProtKB:Q9NZ42}.
uniprot
proteins
mass_dalton
12021
uniprot
proteins
protein_family
PEN-2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
101
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9NZ42}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NZ42}. Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q9NZ42}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NZ42}. Cell membrane {ECO:0000250|UniProtKB:Q9NZ42}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NZ42}. Membrane {ECO:0000250|UniProtKB:Q9NZ42}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NZ42}. Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi. {ECO:0000250|UniProtKB:Q9NZ42}.
uniprot
proteins
transmembrane_region
TRANSMEM 58..78; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NZ42
uniprot
proteins