GRPR
entrez
2925
canonical
uniprot
P30550
canonical
ensembl
ENSG00000126010
resolver
ensp
ENSP00000369643
resolver
enst
ENST00000380289
resolver
genesymbol
GRPR
resolver
hgnc
HGNC:4609
resolver
uniprot
B2R910
resolver
uniprot
X5D7H2
resolver
uniprot_entry
GRPR_HUMAN
resolver
uniprot_entry
X5D7H2_HUMAN
resolver
uniprot_sec
B2R910
resolver
amino_acid_sequence
MALNDCFLLNLEVDHFMHCNISSHSADLPVNDDWSHPGILYVIPAVYGVIILIGLIGNITLIKIFCTVKSMRNVPNLFISSLALGDLLLLITCAPVDASRYLADRWLFGRIGCKLIPFIQLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAAFIWIISMLLAIPEAVFSDLHPFHEESTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLSIISVYYYFIAKNLIQSAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSMLHFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLIIRSHSTGRSTTCMTSLKSTNPSVATFSLINGNICHERYV
uniprot
proteins
function
FUNCTION: Receptor for gastrin-releasing peptide (GRP) (PubMed:1655761). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. In one study, shown to act in the amygdala as part of an inhibitory network which inhibits memory specifically related to learned fear (By similarity). In another study, shown to contribute to disinhibition of glutamatergic cells in the auditory cortex via signaling on vasoactive intestinal peptide-expressing cells which leads to enhanced auditory fear memories (By similarity). Contributes to the induction of sighing through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity). {ECO:0000250|UniProtKB:P21729, ECO:0000269|PubMed:1655761}.
uniprot
proteins
mass_dalton
43199
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11245983
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1655761
uniprot
proteins
pubmed
34610277
uniprot
proteins
sequence_length
384
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1655761}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 39..62; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 77..96; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 115..136; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 153..174; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 209..234; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 265..285; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 299..325; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins