Nutf2
entrez
291981
canonical
uniprot
P61972
canonical
ensembl
ENSRNOG00000018945
resolver
ensembl
ENSRNOG00055018000
resolver
ensembl
ENSRNOG00060011531
resolver
ensembl
ENSRNOG00065012523
resolver
ensp
ENSRNOP00000025608
resolver
ensp
ENSRNOP00055024549
resolver
ensp
ENSRNOP00060015326
resolver
ensp
ENSRNOP00065015660
resolver
enst
ENSRNOT00000025608
resolver
enst
ENSRNOT00055030499
resolver
enst
ENSRNOT00060019510
resolver
enst
ENSRNOT00065020371
resolver
genesymbol
Nutf2
resolver
genesymbol_syn
Ntf2
resolver
uniprot
P13662
resolver
uniprot_entry
NTF2_RAT
resolver
uniprot_sec
P13662
resolver
amino_acid_sequence
MGDKPIWEQIGSSFIQHYYQLFDNDRTQLGAIYIDASCLTWEGQQFQGKAAIVEKLSSLPFQKIQHSITAQDHQPTPDSCIISMVVGQLKADEDPIMGFHQMFLLKNINDAWVCTNDMFRLALHNFG
uniprot
proteins
function
FUNCTION: Mediates the import of GDP-bound RAN from the cytoplasm into the nucleus which is essential for the function of RAN in cargo receptor-mediated nucleocytoplasmic transport. Thereby, plays indirectly a more general role in cargo receptor-mediated nucleocytoplasmic transport. Interacts with GDP-bound RAN in the cytosol, recruits it to the nuclear pore complex via its interaction with nucleoporins and promotes its nuclear import. {ECO:0000269|PubMed:10543952, ECO:0000269|PubMed:9822603}.
uniprot
proteins
mass_dalton
14478
uniprot
proteins
mutagenesis
MUTAGEN 7; /note="W->A: No effect on interaction with GDP-bound RAN. Decreased interaction with nucleoporins. Decreased localization to the nuclear pore complex. Decreased GDP-bound RAN and other proteins nuclear import."; /evidence="ECO:0000269|PubMed:10543952"; MUTAGEN 19; /note="Y->A: Loss of interaction with GDP-bound RAN. Loss of GDP-bound RAN nuclear import."; /evidence="ECO:0000269|PubMed:11038179"; MUTAGEN 23; /note="D->A,N: No effect on interaction with GDP-bound RAN. Increases GDP-bound RAN nuclear import. Increased interaction with nucleoporins and localization to the nuclear pore complex. Inhibits the nuclear import of nuclear localization signal-containing proteins."; /evidence="ECO:0000269|PubMed:11038179, ECO:0000269|PubMed:15522285"; MUTAGEN 23; /note="D->N: No effect on interaction with GDP-bound RAN. No effect on interaction with nucleoporins. No effect on proteins nuclear import."; /evidence="ECO:0000269|PubMed:9368653"; MUTAGEN 42; /note="E->D: Loss of interaction with GDP-bound RAN. Loss of GDP-bound RAN nuclear import."; /evidence="ECO:0000269|PubMed:11038179"; MUTAGEN 42; /note="E->K: Loss of interaction with GDP-bound RAN. No effect on interaction with nucleoporins. Loss of GDP-bound RAN and other proteins nuclear import."; /evidence="ECO:0000269|PubMed:9368653, ECO:0000269|PubMed:9822603"; MUTAGEN 64; /note="I->A: No effect on homodimerization. Decreased interaction with GDP-bound RAN. Loss of interaction with nucleoporins and localization to the nuclear pore complex."; /evidence="ECO:0000269|PubMed:15522285"; MUTAGEN 64; /note="I->Q: No effect on homodimerization. Loss of interaction with GDP-bound RAN. Decreased interaction with nucleoporins and localization to the nuclear pore complex."; /evidence="ECO:0000269|PubMed:15522285"; MUTAGEN 66; /note="H->A: Loss of interaction with GDP-bound RAN. No effect on interaction with nucleoporins. Decreased proteins nuclear import."; /evidence="ECO:0000269|PubMed:9368653"; MUTAGEN 84; /note="M->E: Decreased homodimerization."; /evidence="ECO:0000269|PubMed:11846560"; MUTAGEN 92..94; /note="DED->NEN: Loss of interaction with GDP-bound RAN. No effect on interaction with nucleoporins. Loss of proteins nuclear import."; /evidence="ECO:0000269|PubMed:9368653"; MUTAGEN 102; /note="M->E: Decreased homodimerization."; /evidence="ECO:0000269|PubMed:11846560"; MUTAGEN 117; /note="D->N: Decreased interaction with GDP-bound RAN. No effect on interaction with nucleoporins. No effect on proteins nuclear import."; /evidence="ECO:0000269|PubMed:9368653"; MUTAGEN 118; /note="M->E: Loss of homodimerization. Decreased interaction with GDP-bound RAN. Decreased interaction with nucleoporins. Decreased localization to the nuclear pore complex."; /evidence="ECO:0000269|PubMed:11846560"; MUTAGEN 124; /note="Missing: Loss of interaction with GDP-bound RAN. No effect on interaction with nucleoporins. Decreased proteins nuclear import."; /evidence="ECO:0000269|PubMed:9368653"; MUTAGEN 126; /note="Missing: Decreased interaction with GDP-bound RAN. No effect on interaction with nucleoporins. No effect on proteins nuclear import."; /evidence="ECO:0000269|PubMed:9368653
uniprot
proteins
pubmed
10543952
uniprot
proteins
pubmed
11038179
uniprot
proteins
pubmed
11846560
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15522285
uniprot
proteins
pubmed
8707840
uniprot
proteins
pubmed
8757804
uniprot
proteins
pubmed
8812990
uniprot
proteins
pubmed
9368653
uniprot
proteins
pubmed
9533885
uniprot
proteins
pubmed
9822603
uniprot
proteins
sequence_length
127
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:9822603}. Nucleus outer membrane {ECO:0000269|PubMed:10543952, ECO:0000269|PubMed:11846560, ECO:0000269|PubMed:15522285, ECO:0000269|PubMed:9822603}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:10543952, ECO:0000269|PubMed:11846560, ECO:0000269|PubMed:15522285}. Nucleus inner membrane {ECO:0000269|PubMed:10543952, ECO:0000269|PubMed:11846560}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:P61970}. Note=At steady state it is essentially nucleoplasmic, enriched in nucleoplasmic foci. {ECO:0000250|UniProtKB:P61970}.
uniprot
proteins