HLA-F
entrez
3134
canonical
uniprot
P30511
canonical
ensembl
ENSG00000137403
resolver
ensembl
ENSG00000204642
resolver
ensembl
ENSG00000206509
resolver
ensembl
ENSG00000229698
resolver
ensembl
ENSG00000235220
resolver
ensembl
ENSG00000237508
resolver
ensp
ENSP00000259951
resolver
ensp
ENSP00000334263
resolver
ensp
ENSP00000345828
resolver
ensp
ENSP00000373008
resolver
ensp
ENSP00000373121
resolver
ensp
ENSP00000373123
resolver
ensp
ENSP00000387786
resolver
ensp
ENSP00000395853
resolver
ensp
ENSP00000397376
resolver
ensp
ENSP00000402853
resolver
ensp
ENSP00000408540
resolver
ensp
ENSP00000414905
resolver
ensp
ENSP00000447228
resolver
ensp
ENSP00000447401
resolver
ensp
ENSP00000448260
resolver
ensp
ENSP00000450119
resolver
ensp
ENSP00000450300
resolver
ensp
ENSP00000695622
resolver
ensp
ENSP00000786704
resolver
ensp
ENSP00000786705
resolver
enst
ENST00000342322
resolver
enst
ENST00000383516
resolver
enst
ENST00000383626
resolver
enst
ENST00000383627
resolver
enst
ENST00000422711
resolver
enst
ENST00000428296
resolver
enst
ENST00000435058
resolver
enst
ENST00000444891
resolver
enst
ENST00000445657
resolver
enst
ENST00000549422
resolver
enst
ENST00000550932
resolver
enst
ENST00000551780
resolver
enst
ENST00000551832
resolver
enst
ENST00000552082
resolver
genesymbol
HLA-F
resolver
genesymbol_syn
HLA-5.4
resolver
genesymbol_syn
HLAF
resolver
hgnc
HGNC:4963
resolver
uniprot
A0A0G2JH66
resolver
uniprot
A0A0G2JL85
resolver
uniprot
D0EV57
resolver
uniprot
Q5JQI8
resolver
uniprot
Q5JQJ1
resolver
uniprot
Q5JZ47
resolver
uniprot
Q5SPT5
resolver
uniprot
Q860R0
resolver
uniprot
Q8MGQ1
resolver
uniprot
Q8WLP5
resolver
uniprot
Q95HC0
resolver
uniprot
Q9TP68
resolver
uniprot_entry
A0A0G2JH66_HUMAN
resolver
uniprot_entry
A0A0G2JL85_HUMAN
resolver
uniprot_entry
D0EV57_HUMAN
resolver
uniprot_entry
HLAF_HUMAN
resolver
uniprot_entry
Q5JZ47_HUMAN
resolver
uniprot_sec
Q5JQI8
resolver
uniprot_sec
Q5JQJ1
resolver
uniprot_sec
Q5SPT5
resolver
uniprot_sec
Q860R0
resolver
uniprot_sec
Q8MGQ1
resolver
uniprot_sec
Q8WLP5
resolver
uniprot_sec
Q95HC0
resolver
uniprot_sec
Q9TP68
resolver
amino_acid_sequence
MAPRSLLLLLSGALALTDTWAGSHSLRYFSTAVSRPGRGEPRYIAVEYVDDTQFLRFDSDAAIPRMEPREPWVEQEGPQYWEWTTGYAKANAQTDRVALRNLLRRYNQSEAGSHTLQGMNGCDMGPDGRLLRGYHQHAYDGKDYISLNEDLRSWTAADTVAQITQRFYEAEEYAEEFRTYLEGECLELLRRYLENGKETLQRADPPKAHVAHHPISDHEATLRCWALGFYPAEITLTWQRDGEEQTQDTELVETRPAGDGTFQKWAAVVVPPGEEQRYTCHVQHEGLPQPLILRWEQSPQPTIPIVGIVAGLVVLGAVVTGAVVAAVMWRKKSSDRNRGSYSQAAV
uniprot
proteins
function
FUNCTION: Non-classical major histocompatibility class Ib molecule postulated to play a role in immune surveillance, immune tolerance and inflammation. Functions in two forms, as a heterotrimeric complex with B2M/beta-2 microglobulin and a peptide (peptide-bound HLA-F-B2M) and as an open conformer (OC) devoid of peptide and B2M (peptide-free OC). In complex with B2M, presents non-canonical self-peptides carrying post-translational modifications, particularly phosphorylated self-peptides. Peptide-bound HLA-F-B2M acts as a ligand for LILRB1 inhibitory receptor, a major player in maternal-fetal tolerance. Peptide-free OC acts as a ligand for KIR3DS1 and KIR3DL2 receptors (PubMed:28636952). Upon interaction with activating KIR3DS1 receptor on NK cells, triggers NK cell degranulation and anti-viral cytokine production (PubMed:27455421). Through interaction with KIR3DL2 receptor, inhibits NK and T cell effector functions (PubMed:24018270). May interact with other MHC class I OCs to cross-present exogenous viral, tumor or minor histompatibility antigens to cytotoxic CD8+ T cells, triggering effector and memory responses (PubMed:23851683). May play a role in inflammatory responses in the peripheral nervous system. Through interaction with KIR3DL2, may protect motor neurons from astrocyte-induced toxicity (PubMed:26928464). {ECO:0000269|PubMed:23851683, ECO:0000269|PubMed:24018270, ECO:0000269|PubMed:26928464, ECO:0000269|PubMed:27455421, ECO:0000269|PubMed:28636952}.
uniprot
proteins
mass_dalton
39062
uniprot
proteins
mutagenesis
MUTAGEN 83; /note="W->R: Impairs peptide binding."; /evidence="ECO:0000269|PubMed:28636952"; MUTAGEN 336..338; /note="RNR->AAA: Impairs the interaction with 14-3-3 proteins."; /evidence="ECO:0000269|PubMed:16709803"; MUTAGEN 336..338; /note="RNR->GKG: Impairs the anterograde ER-to-Golgi transport."; /evidence="ECO:0000269|PubMed:16709803"; MUTAGEN 346; /note="V->S: Impairs the anterograde ER-to-Golgi transport."; /evidence="ECO:0000269|PubMed:16709803"; MUTAGEN 346; /note="Missing: Impairs the interaction with coat protein complex II; impairs the anterograde ER-to-Golgi transport."; /evidence="ECO:0000269|PubMed:16709803
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:10605026, ECO:0000269|PubMed:27455421}.
uniprot
proteins
protein_family
MHC class I family
uniprot
proteins
pubmed
10605026
uniprot
proteins
pubmed
10727083
uniprot
proteins
pubmed
11169396
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14705989
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16570139
uniprot
proteins
pubmed
16709803
uniprot
proteins
pubmed
1688605
uniprot
proteins
pubmed
1707659
uniprot
proteins
pubmed
20483783
uniprot
proteins
pubmed
20865824
uniprot
proteins
pubmed
23851683
uniprot
proteins
pubmed
24018270
uniprot
proteins
pubmed
26928464
uniprot
proteins
pubmed
27455421
uniprot
proteins
pubmed
28185362
uniprot
proteins
pubmed
28636952
uniprot
proteins
sequence_length
346
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16709803, ECO:0000269|PubMed:23851683, ECO:0000305|PubMed:27455421}; Single-pass type I membrane protein. Early endosome membrane {ECO:0000269|PubMed:23851683}. Lysosome membrane {ECO:0000269|PubMed:23851683}. Note=For cross-presentation transits from the cell surface through endosomal pathway to lysosomes, where the peptide is generated from internalized exogenous antigen. {ECO:0000269|PubMed:23851683}.
uniprot
proteins
transmembrane_region
TRANSMEM 306..329; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins