Calcoco1
entrez
246047
canonical
uniprot
Q66HR5
canonical
ensembl
ENSRNOG00000015447
resolver
ensembl
ENSRNOG00065022869
resolver
ensp
ENSRNOP00000021522
resolver
ensp
ENSRNOP00000071559
resolver
ensp
ENSRNOP00065031771
resolver
enst
ENSRNOT00000021523
resolver
enst
ENSRNOT00000089290
resolver
enst
ENSRNOT00065039117
resolver
genesymbol
Calcoco1
resolver
uniprot
A0A0G2K0S1
resolver
uniprot
Q8R443
resolver
uniprot_entry
A0A0G2K0S1_RAT
resolver
uniprot_entry
CACO1_RAT
resolver
uniprot_sec
Q8R443
resolver
amino_acid_sequence
MEESSLSRAPSRGGVSFLNVARTYVPNTKVECHYTLPPGTTPSASDWIGIFKVEAACVRDYHTFVWSSVPETTTDGSPTHASVQFQASYLPKPGAQLYQFRYVNRQGRVCGQSPPFQFREPRPMDELVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEDQVTELRSRVQELEAALATARQEHSELTEQYKGLSRSHGELSEERDILSQQQGEHVARILELEDDIQTMSDKVLMKEVELDRVRDMVKALTREQEKLLGQLKEFQADKEQSEAELQTVREENCHLNTELQEAKGRQEEQGAQVQRLKDKVAHMKDTLGQTQQKVAELEPLKEQLRGVQELAASSQQKAALLGEELASAAGARDRTIAELHRSRLEVAEVNGRLAELSLHMKEEKCQWSKERTGLLQSMEAEKDKILKLSAEILRLEKTVQEERSQSHMFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQTEKQELLEYMRKLEARLEKVADEKWNEDAATEDEEATAGLSCPAALTDSEDESPEDMRLPSYGLCERGNTSSSPPGPRESSSLVVINQPAPIAPQLSGPGEASSSDSEAEDEKSVLMAAVQSGGEEANLLLPELGSTFYDVASGFAVSSLSEASTGVPAIPAWKECPICKERFPAESDKDALEDHMDGHFFFSTQDPFTFE
uniprot
proteins
function
FUNCTION: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions. In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (By similarity). {ECO:0000250|UniProtKB:Q8CGU1}.; FUNCTION: Seems to enhance inorganic pyrophosphatase thus activating phosphogluomutase (PMG). Probably functions as a component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
77275
uniprot
proteins
protein_family
CALCOCO family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
691
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Shuttles between nucleus and cytoplasm. {ECO:0000250}.
uniprot
proteins