Acadl
entrez
25287
canonical
uniprot
P15650
canonical
ensembl
ENSRNOG00000012966
resolver
ensembl
ENSRNOG00055010322
resolver
ensembl
ENSRNOG00060023597
resolver
ensembl
ENSRNOG00065028069
resolver
ensp
ENSRNOP00000017686
resolver
ensp
ENSRNOP00055014075
resolver
ensp
ENSRNOP00060033937
resolver
ensp
ENSRNOP00065039723
resolver
enst
ENSRNOT00055017478
resolver
enst
ENSRNOT00060041009
resolver
enst
ENSRNOT00065048431
resolver
genesymbol
Acadl
resolver
uniprot_entry
ACADL_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by crotonyl-CoA, 2-octenoyl-CoA and 2-hexadecenoyl-CoA. {ECO:0000269|PubMed:3968063}.
uniprot
proteins
amino_acid_sequence
MAARLLLRSLRVLSARSATLPPPSARCSHSGAEARLETPSAKKLTDIGIRRIFSSEHDIFRESVRKFFQEEVIPYHEEWEKAGEVSRELWEKAGKQGLLGINIAEKHGGIGGDLLSTAVTWEEQAYSNCTGPGFSLHSDIVMPYIANYGTKEQIEQFIPQMTAGKCIGAIAMTEPGAGSDLQGVRTNAKRSGSDWILNGSKVFITNGWLSDLVIVVAVTNREARSPAHGISLFLVENGMKGFIKGKKLHKMGMKAQDTAELFFEDVRLPASALLGEENKGFYYLMQELPQERLLIADLAISACEFMFEETRNYVRQRKAFGKTVAHIQTVQHKLAELKTNICVTRAFVDSCLQLHETKRLDSASASMAKYWASELQNTVAYQCVQLHGGWGYMWEYPIAKAYVDARVQPIYGGTNEIMKELIARQIVSDS
uniprot
proteins
ec_number
1.3.8.7
uniprot
proteins
ec_number
1.3.8.8
uniprot
proteins
function
FUNCTION: Catalyzes the first of the four reactions of the mitochondrial fatty acid beta-oxidation (FAO) pathway, which consists in the proR-proR stereospecific alpha, beta-dehydrogenation of fatty acyl-CoA thioesters using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor, resulting in the formation of trans-2-enoyl-CoA ((2E)-enoyl-CoA) (PubMed:3968063). The mitochondrial FAO pathway is the major energy-producing process in tissues and is performed through cycles of four consecutive reactions (PubMed:3968063). Each FAO cycle shortens the fatty acyl-CoA by two carbons, yielding one acetyl-CoA (for the citric acid cycle), one FADH(2), and one NADH (which donate electrons to the respiratory chain for ATP production) (By similarity) (PubMed:3968063). Among the different mitochondrial acyl-CoA dehydrogenases, long-chain specific acyl-CoA dehydrogenase activity overlaps with that of ACADV and ACAD9, acting on saturated and unsaturated acyl-CoAs with 6 to 24 carbons with a preference for 8 to 18 carbons long primary chains (PubMed:15466478, PubMed:3968063). Can use (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate as substrate in vitro (which is not primarily used for energy but mainly beta-oxidized in the peroxisomes). In addition, based on its established catalytic mechanism, and combined genetic interaction or mutant phenotype evidence, it is predicted to act also on substrates that have not been tested experimentally but are metabolized by mitochondrial FAO, including long-chain unsaturated fatty acids such as linoleate (9Z,12Z-octadecadienoate), linolenate (9Z,12Z,15Z-octadecatrienoate), and others. Plays a primary role in FAO in tissues where it is the main long-chain ACAD expressed. Probably responsible for beta-oxidation of bulky substrates including branched chain fatty acyl-CoAs and sterol derivatives thanks to its enlarged substrate-binding cavity (By similarity). {ECO:0000250|UniProtKB:P28330, ECO:0000269|PubMed:15466478, ECO:0000269|PubMed:3968063}.
uniprot
proteins
mass_dalton
47873
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; mitochondrial fatty acid beta-oxidation. {ECO:0000303|PubMed:3968063}.
uniprot
proteins
post_translational_modification
PTM: Acetylation at Lys-318 and Lys-322 in proximity of the cofactor-binding sites strongly reduces catalytic activity. These sites are deacetylated by SIRT3. {ECO:0000250|UniProtKB:P51174}.
uniprot
proteins
protein_family
Acyl-CoA dehydrogenase family
uniprot
proteins
pubmed
15466478
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2777793
uniprot
proteins
pubmed
3813556
uniprot
proteins
pubmed
3968063
uniprot
proteins
pubmed
8268228
uniprot
proteins
sequence_length
430
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:3813556}.
uniprot
proteins