Mkrn3
entrez
22652
canonical
uniprot
Q60764
canonical
ensembl
ENSMUSG00000070527
resolver
ensp
ENSMUSP00000091898
resolver
enst
ENSMUST00000094340
resolver
genesymbol
Mkrn3
resolver
genesymbol_syn
Zfp127
resolver
genesymbol_syn
Znf127
resolver
uniprot
Q3UY92
resolver
uniprot
Q7TQE4
resolver
uniprot_entry
MKRN3_MOUSE
resolver
uniprot_sec
Q3UY92
resolver
uniprot_sec
Q7TQE4
resolver
amino_acid_sequence
MEESTAPIEAHAAAGAEAGAEGGEGVSVPPPPQFEAAGASAGVSSAPLQQASGLAPLLVTPGPAIRRAASLRPAPAEGGGARSGPERNSGSWTKQILCRYYLHGQCKEGDNCRYSHDLSGRRRSRGGQDAQPRASADRGPKMATRWEPPTQEVAEAPPAASSSSLPLIGSAAERGFTEAEIDNAGIRSAAERGFSEAEIDNASLAAGAAAGAGAEGWEGAIEFVPGQPYRGRMVPPHGPEAPLQSPAIEREHMAMGMGMPMPVPMPMPVPMPVPMPLPLCRYAARGQCLRGDRCAYPHGEICDMCGQQALHPWDAAQQEAHRRACVEAHERDMELSFAVQRSMDKVCGICMEVVYEKADPSDRRFGILFSCNHTYCLRCIRRWRSATQFENRISKSCPQCRVSSGFVIPSEFWVEEEEEKEKLVQQYKEGMSQKACRYFAGGLGHCPFGEFCFYKHEYPEGWRDQPPRPDGGGSSSAYWHQVLEPVQLREGNVLFKSRKKEHSVLRLANQLLKKLLCLRGSSSFSDDRWLLLQYQLEEYFSLNL
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Acts as a key developmental timer that helps ensure puberty begins at the appropriate age, by inhibiting premature activation of the reproductive hormone cascade (PubMed:37092553). Epigenetically regulates GNRH1 transcription by disrupting the binding of methyl-DNA binding protein 3/MBD3 to the promoter of GNRH1. Mechanistically, mediates the non-proteolytic ubiquitination of MBD3 at multiple sites with 'Lys27' ubiquitin linkages and thereby regulates the methylation status of the genome, including GNRH1 promoter (PubMed:34692086). Modulates the stability and translation of GNRH1 mRNA by mediating the non-proteolytic ubiquitination of PABP family members PABPC1, PABPC3 and PABPC4 at multiple sites (PubMed:33744966). Also participates in the maintenance of genomic and epigenomic stability by regulating the abundance of APEX2 via 'Lys-48'-linked ubiquitination (By similarity). {ECO:0000250|UniProtKB:Q13064, ECO:0000269|PubMed:33744966, ECO:0000269|PubMed:34692086, ECO:0000269|PubMed:37092553}.
uniprot
proteins
mass_dalton
59434
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
10196368
uniprot
proteins
pubmed
10395905
uniprot
proteins
pubmed
12971993
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23738509
uniprot
proteins
pubmed
33744966
uniprot
proteins
pubmed
34692086
uniprot
proteins
pubmed
37092553
uniprot
proteins
sequence_length
544
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:34692086}.
uniprot
proteins