GPC4
entrez
2239
canonical
uniprot
O75487
canonical
ensembl
ENSG00000076716
resolver
ensp
ENSP00000359864
resolver
genesymbol
GPC4
resolver
hgnc
HGNC:4452
resolver
uniprot
B2R6J7
resolver
uniprot
B4E2C0
resolver
uniprot
Q6ZMA6
resolver
uniprot
Q96L43
resolver
uniprot
Q9NU08
resolver
uniprot
Q9UJN1
resolver
uniprot
Q9UPD9
resolver
uniprot_entry
GPC4_HUMAN
resolver
uniprot_sec
B2R6J7
resolver
uniprot_sec
B4E2C0
resolver
uniprot_sec
Q6ZMA6
resolver
uniprot_sec
Q96L43
resolver
uniprot_sec
Q9NU08
resolver
uniprot_sec
Q9UJN1
resolver
uniprot_sec
Q9UPD9
resolver
amino_acid_sequence
MARFGLPALLCTLAVLSAALLAAELKSKSCSEVRRLYVSKGFNKNDAPLHEINGDHLKICPQGSTCCSQEMEEKYSLQSKDDFKSVVSEQCNHLQAVFASRYKKFDEFFKELLENAEKSLNDMFVKTYGHLYMQNSELFKDLFVELKRYYVVGNVNLEEMLNDFWARLLERMFRLVNSQYHFTDEYLECVSKYTEQLKPFGDVPRKLKLQVTRAFVAARTFAQGLAVAGDVVSKVSVVNPTAQCTHALLKMIYCSHCRGLVTVKPCYNYCSNIMRGCLANQGDLDFEWNNFIDAMLMVAERLEGPFNIESVMDPIDVKISDAIMNMQDNSVQVSQKVFQGCGPPKPLPAGRISRSISESAFSARFRPHHPEERPTTAAGTSLDRLVTDVKEKLKQAKKFWSSLPSNVCNDERMAAGNGNEDDCWNGKGKSRYLFAVTGNGLANQGNNPEVQVDTSKPDILILRQIMALRVMTSKMKNAYNGNDVDFFDISDESSGEGSGSGCEYQQCPSEFDYNATDHAGKSANEKADSAGVRPGAQAYLLTVFCILFLVMQREWR
uniprot
proteins
disease_involvement
DISEASE: Keipert syndrome (KPTS) [MIM:301026]: An X-linked recessive syndrome characterized by craniofacial and digital abnormalities. Clinical features include a prominent forehead, a flat midface, hypertelorism, a broad nose, downturned corners of mouth, and widening of all distal phalanges. Additional variable features are cognitive impairment and sensorineural deafness. {ECO:0000269|PubMed:30982611}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
62412
uniprot
proteins
protein_family
Glypican family
uniprot
proteins
pubmed
10814714
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
29276006
uniprot
proteins
pubmed
30982611
uniprot
proteins
pubmed
9787072
uniprot
proteins
sequence_length
556
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}; Extracellular side {ECO:0000250}.; SUBCELLULAR LOCATION: [Secreted glypican-4]: Secreted, extracellular space {ECO:0000250}.
uniprot
proteins