Klk14
entrez
317653
canonical
uniprot
Q8CGR5
canonical
ensembl
ENSMUSG00000044737
resolver
ensp
ENSMUSP00000056935
resolver
enst
ENSMUST00000056329
resolver
genesymbol
Klk14
resolver
genesymbol_syn
Gk14
resolver
uniprot
A0A0B6VSR0
resolver
uniprot_entry
A0A0B6VSR0_MOUSE
resolver
uniprot_entry
KLK14_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by SERPINA1, SERPINC1, SERPINE1, SERPINF2, aprotinin, soybean, trypsin inhibitor and leupeptin. Inhibited by serine protease inhibitor SPINK5. Has an autoproteolytic activity which may have a regulatory effect. Activated by citrate and inhibited by zinc and to a lower extent by manganese (By similarity). {ECO:0000250|UniProtKB:Q9P0G3}.
uniprot
proteins
amino_acid_sequence
MFLLLIILQALAVAIAQSQGDHKIIGGYRCVRNSQPWQVALQAGPGHRFLCGGVLLSDQWVITAAHCARPILHVALGKHNIRRWEATQQVVRVARQVPHPQYQPQAHDNDLMLLKLQKKVRLGRAVKTISVASSCASPGTPCRVSGWGTIASPIARYPTALQCVNVNIMSEQACHRAYPGIITSGMVCAGVPEGGKDSCQGDSGGPLVCGGQLQGLVSWGMERCAMPGYPGVYANLCNYHSWIQRTMQSN
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis (By similarity). {ECO:0000250|UniProtKB:Q9P0G3}.
uniprot
proteins
mass_dalton
27016
uniprot
proteins
post_translational_modification
PTM: Proteolytic cleavage of the activation peptide produces the active enzyme. {ECO:0000250|UniProtKB:Q9P0G3}.
uniprot
proteins
protein_family
Kallikrein subfamily
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
12437987
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
250
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000250|UniProtKB:Q9P0G3}.
uniprot
proteins