LPAR6
entrez
10161
canonical
uniprot
P43657
canonical
ensembl
ENSG00000139679
resolver
ensp
ENSP00000344353
resolver
ensp
ENSP00000367691
resolver
ensp
ENSP00000482660
resolver
ensp
ENSP00000611240
resolver
enst
ENST00000345941
resolver
enst
ENST00000378434
resolver
enst
ENST00000620633
resolver
enst
ENST00000941181
resolver
genesymbol
LPAR6
resolver
genesymbol_syn
P2RY5
resolver
hgnc
HGNC:15520
resolver
uniprot
A4FTW9
resolver
uniprot
B3KVF2
resolver
uniprot
B3KVQ5
resolver
uniprot
F2YGU4
resolver
uniprot
O15133
resolver
uniprot
Q3KPF5
resolver
uniprot
Q53FA0
resolver
uniprot
Q5VW44
resolver
uniprot
Q7Z3S0
resolver
uniprot
Q7Z3S6
resolver
uniprot_entry
B3KVQ5_HUMAN
resolver
uniprot_entry
LPAR6_HUMAN
resolver
uniprot_sec
A4FTW9
resolver
uniprot_sec
B3KVF2
resolver
uniprot_sec
F2YGU4
resolver
uniprot_sec
O15133
resolver
uniprot_sec
Q3KPF5
resolver
uniprot_sec
Q53FA0
resolver
uniprot_sec
Q5VW44
resolver
uniprot_sec
Q7Z3S0
resolver
uniprot_sec
Q7Z3S6
resolver
amino_acid_sequence
MVSVNSSHCFYNDSFKYTLYGCMFSMVFVLGLISNCVAIYIFICVLKVRNETTTYMINLAMSDLLFVFTLPFRIFYFTTRNWPFGDLLCKISVMLFYTNMYGSILFLTCISVDRFLAIVYPFKSKTLRTKRNAKIVCTGVWLTVIGGSAPAVFVQSTHSQGNNASEACFENFPEATWKTYLSRIVIFIEIVGFFIPLILNVTCSSMVLKTLTKPVTLSRSKINKTKVLKMIFVHLIIFCFCFVPYNINLILYSLVRTQTFVNCSVVAAVRTMYPITLCIAVSNCCFDPIVYYFTSDTIQNSIKMKNWSVRRSDFRFSEVHGAENFIQHNLQTLKSKIFDNESAA
uniprot
proteins
disease_involvement
DISEASE: Woolly hair autosomal recessive 1 with or without hypotrichosis (ARWH1) [MIM:278150]: A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. Some individuals exhibit features of hypotrichosis. {ECO:0000269|PubMed:18297070, ECO:0000269|PubMed:18297072, ECO:0000269|PubMed:18461368, ECO:0000269|PubMed:18692127, ECO:0000269|PubMed:21426374, ECO:0000269|PubMed:28425126, ECO:0000269|PubMed:36173926}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Hypotrichosis 8 (HYPT8) [MIM:278150]: A condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The disorder affects the trunk and extremities as well as the scalp, and the eyebrows and eyelashes may also be involved, whereas beard, pubic, and axillary hairs are largely spared. In addition, patients can develop hyperkeratotic follicular papules, erythema, and pruritus in affected areas. In some patients with congenital hypotrichosis, monilethrix-like hairs showing elliptical nodes have been observed. HYPT8 inheritance is autosomal recessive. {ECO:0000269|PubMed:18297070, ECO:0000269|PubMed:18461368, ECO:0000269|PubMed:19292720, ECO:0000269|PubMed:21070332, ECO:0000269|PubMed:21426374, ECO:0000269|PubMed:36173926}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Binds to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation. Important for the maintenance of hair growth and texture. {ECO:0000269|PubMed:18297070}.
uniprot
proteins
mass_dalton
39392
uniprot
proteins
mutagenesis
MUTAGEN 246; /note="N->D: Loss of G protein-coupled receptor signaling. Reduced localization to cell membrane. Decreased protein abundance. Increased protein degradation."; /evidence="ECO:0000269|PubMed:36173926
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11004484
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18297070
uniprot
proteins
pubmed
18297072
uniprot
proteins
pubmed
18461368
uniprot
proteins
pubmed
18692127
uniprot
proteins
pubmed
19292720
uniprot
proteins
pubmed
21070332
uniprot
proteins
pubmed
21426374
uniprot
proteins
pubmed
28425126
uniprot
proteins
pubmed
36173926
uniprot
proteins
pubmed
7902321
uniprot
proteins
pubmed
8889552
uniprot
proteins
sequence_length
344
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18297070, ECO:0000269|PubMed:36173926}; Multi-pass membrane protein {ECO:0000269|PubMed:18297070}.
uniprot
proteins
transmembrane_region
TRANSMEM 20..46; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 56..79; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 93..112; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 134..154; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 182..209; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 228..253; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 273..292; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins