Atp1b1
entrez
11931
canonical
uniprot
P14094
canonical
ensembl
ENSMUSG00000026576
resolver
ensp
ENSMUSP00000027863
resolver
enst
ENSMUST00000027863
resolver
genesymbol
Atp1b1
resolver
genesymbol_syn
Atp4b
resolver
uniprot
Q3TV47
resolver
uniprot
Q545P0
resolver
uniprot_entry
AT1B1_MOUSE
resolver
uniprot_entry
Q3TV47_MOUSE
resolver
uniprot_entry
Q545P0_MOUSE
resolver
amino_acid_sequence
MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISELKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIIRFLEKYKDSAQKDDMIFEDCGNVPSEPKERGDINHERGERKVCRFKLDWLGNCSGLNDDSYGYREGKPCIIIKLNRVLGFKPKPPKNESLETYPLMMKYNPNVLPVQCTGKRDEDKDKVGNIEYFGMGGYYGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTVDTEIRVECKAYGENIGYSEKDRFQGRFDVKIEIKS
uniprot
proteins
function
FUNCTION: Non-catalytic subunit of the Na(+)/K(+)-ATPase pump that hydrolyzes ATP to exchange ions across the plasma membrane, exporting 3 Na(+) and importing 2 K(+) per cycle against electrochemical gradients. The beta subunit is important for the folding, stability, and targeting of the Na(+)/K(+)-ATPase pump to the plasma membranes (By similarity). In addition, acts as a homotypic cell adhesion molecule in epithelia cells. Interactions between ATP1B1 on neighboring cells are critical for proper lateral polarization of the Na(+)/K(+)-ATPase pump and for stabilizing cell-cell adhesion (By similarity). Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1 (By similarity). {ECO:0000250|UniProtKB:P05026, ECO:0000250|UniProtKB:P06583, ECO:0000250|UniProtKB:Q91580}.
uniprot
proteins
mass_dalton
35195
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by RNF183 leading to its lysosomal degradation. {ECO:0000250|UniProtKB:P05026}.; PTM: Glutathionylated (PubMed:21454534). N-glycosylated; promotes the stability of ATP1B1 homotypic interactions (By similarity). {ECO:0000250|UniProtKB:P07340, ECO:0000269|PubMed:21454534}.
uniprot
proteins
protein_family
X(+)/potassium ATPases subunit beta family
uniprot
proteins
pubmed
12106288
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15743908
uniprot
proteins
pubmed
17606467
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21454534
uniprot
proteins
pubmed
23392350
uniprot
proteins
pubmed
2557580
uniprot
proteins
pubmed
30012868
uniprot
proteins
sequence_length
304
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P05026}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P05027}. Apical cell membrane {ECO:0000250|UniProtKB:P07340}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P05027}. Cell membrane, sarcolemma {ECO:0000269|PubMed:23392350}. Note=Colocalizes with OBSCN at the intercalated disk and sarcolemma in cardiomyocytes. Localizes in long striations at the level of Z and M lines. {ECO:0000269|PubMed:23392350}.
uniprot
proteins
transmembrane_region
TRANSMEM 35..62; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000250|UniProtKB:P05027
uniprot
proteins