CLIC1
entrez
1192
canonical
uniprot
O00299
canonical
ensembl
ENSG00000206394
resolver
ensembl
ENSG00000213719
resolver
ensembl
ENSG00000223639
resolver
ensembl
ENSG00000226248
resolver
ensembl
ENSG00000226417
resolver
ensembl
ENSG00000226651
resolver
ensembl
ENSG00000230685
resolver
ensp
ENSP00000364934
resolver
ensp
ENSP00000364935
resolver
ensp
ENSP00000364940
resolver
ensp
ENSP00000372896
resolver
ensp
ENSP00000372897
resolver
ensp
ENSP00000379229
resolver
ensp
ENSP00000382926
resolver
ensp
ENSP00000382931
resolver
ensp
ENSP00000391395
resolver
ensp
ENSP00000398056
resolver
ensp
ENSP00000400280
resolver
ensp
ENSP00000400532
resolver
ensp
ENSP00000401292
resolver
ensp
ENSP00000404037
resolver
ensp
ENSP00000404589
resolver
ensp
ENSP00000406088
resolver
ensp
ENSP00000406335
resolver
ensp
ENSP00000406968
resolver
ensp
ENSP00000407429
resolver
ensp
ENSP00000407791
resolver
ensp
ENSP00000408094
resolver
ensp
ENSP00000408357
resolver
ensp
ENSP00000409247
resolver
ensp
ENSP00000409979
resolver
ensp
ENSP00000410965
resolver
ensp
ENSP00000412217
resolver
ensp
ENSP00000413330
resolver
ensp
ENSP00000416211
resolver
ensp
ENSP00000477623
resolver
ensp
ENSP00000478930
resolver
ensp
ENSP00000479501
resolver
ensp
ENSP00000479808
resolver
ensp
ENSP00000480256
resolver
ensp
ENSP00000482255
resolver
ensp
ENSP00000484581
resolver
ensp
ENSP00000535054
resolver
ensp
ENSP00000535055
resolver
ensp
ENSP00000617516
resolver
ensp
ENSP00000617517
resolver
ensp
ENSP00000617518
resolver
enst
ENST00000375779
resolver
enst
ENST00000375780
resolver
enst
ENST00000375784
resolver
enst
ENST00000383404
resolver
enst
ENST00000383405
resolver
enst
ENST00000395892
resolver
enst
ENST00000400052
resolver
enst
ENST00000400058
resolver
enst
ENST00000415179
resolver
enst
ENST00000418285
resolver
enst
ENST00000420458
resolver
enst
ENST00000422167
resolver
enst
ENST00000423055
resolver
enst
ENST00000423143
resolver
enst
ENST00000423804
resolver
enst
ENST00000425464
resolver
enst
ENST00000431921
resolver
enst
ENST00000433916
resolver
enst
ENST00000434202
resolver
enst
ENST00000435242
resolver
enst
ENST00000438708
resolver
enst
ENST00000438750
resolver
enst
ENST00000442045
resolver
enst
ENST00000447338
resolver
enst
ENST00000447369
resolver
enst
ENST00000451546
resolver
enst
ENST00000456863
resolver
enst
ENST00000457485
resolver
enst
ENST00000614673
resolver
enst
ENST00000614982
resolver
enst
ENST00000616760
resolver
enst
ENST00000618288
resolver
enst
ENST00000619727
resolver
enst
ENST00000621055
resolver
enst
ENST00000622613
resolver
enst
ENST00000864995
resolver
enst
ENST00000864996
resolver
enst
ENST00000947457
resolver
enst
ENST00000947458
resolver
enst
ENST00000947459
resolver
genesymbol
CLIC1
resolver
genesymbol_syn
G6
resolver
genesymbol_syn
NCC27
resolver
hgnc
HGNC:2062
resolver
uniprot
Q15089
resolver
uniprot
Q502X1
resolver
uniprot
Q53FB0
resolver
uniprot
Q5SRT3
resolver
uniprot_entry
CLIC1_HUMAN
resolver
uniprot_entry
Q53FB0_HUMAN
resolver
uniprot_entry
Q5SRT3_HUMAN
resolver
uniprot_sec
Q15089
resolver
uniprot_sec
Q502X1
resolver
activity_regulation
ACTIVITY REGULATION: The oxidoreductase activity is inhibited by rapamycin, amphotericin B and IAA-94 (PubMed:25581026, PubMed:37759794). The channel conductance is regulated by pH and redox membrane potential. Inhibited by IAA-94 (PubMed:10874038, PubMed:11978800, PubMed:16339885). {ECO:0000269|PubMed:10874038, ECO:0000269|PubMed:11978800, ECO:0000269|PubMed:16339885, ECO:0000269|PubMed:25581026, ECO:0000269|PubMed:37759794}.
uniprot
proteins
amino_acid_sequence
MAEEQPQVELFVKAGSDGAKIGNCPFSQRLFMVLWLKGVTFNVTTVDTKRRTETVQKLCPGGQLPFLLYGTEVHTDTNKIEEFLEAVLCPPRYPKLAALNPESNTAGLDIFAKFSAYIKNSNPALNDNLEKGLLKALKVLDNYLTSPLPEEVDETSAEDEGVSQRKFLDGNELTLADCNLLPKLHIVQVVCKKYRGFTIPEAFRGVHRYLSNAYAREEFASTCPDDEEIELAYEQVAKALK
uniprot
proteins
ec_number
1.8.-.-
uniprot
proteins
ec_number
1.8.5.1
uniprot
proteins
function
FUNCTION: In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduces selenite and dehydroascorbate and may act as an antioxidant during oxidative stress response (PubMed:25581026, PubMed:37759794). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Involved in regulation of the cell cycle. {ECO:0000269|PubMed:10834939, ECO:0000269|PubMed:10874038, ECO:0000269|PubMed:11195932, ECO:0000269|PubMed:11551966, ECO:0000269|PubMed:11940526, ECO:0000269|PubMed:11978800, ECO:0000269|PubMed:14613939, ECO:0000269|PubMed:16339885, ECO:0000269|PubMed:25581026, ECO:0000269|PubMed:37759794, ECO:0000269|PubMed:9139710}.
uniprot
proteins
mass_dalton
26923
uniprot
proteins
mutagenesis
MUTAGEN 24; /note="C->A,S: Loss of glutathione-dependent oxidoreductase activity. Reduces channel conductance and abolishes its dependence on membrane redox potential."; /evidence="ECO:0000269|PubMed:16339885, ECO:0000269|PubMed:25581026, ECO:0000269|PubMed:37759794"; MUTAGEN 24; /note="C->S: Loss of dimerization and of ion transport activity."; /evidence="ECO:0000269|PubMed:14613939"; MUTAGEN 37; /note="K->A: Decreases glutathione-dependent oxidoreductase activity."; /evidence="ECO:0000269|PubMed:37759794"; MUTAGEN 59; /note="C->A: Loss of glutathione-dependent oxidoreductase activity."; /evidence="ECO:0000269|PubMed:25581026, ECO:0000269|PubMed:37759794"; MUTAGEN 59; /note="C->S: Loss of dimerization and of ion transport activity."; /evidence="ECO:0000269|PubMed:14613939
uniprot
proteins
post_translational_modification
PTM: Hydrogen peroxide treatment causes a conformation change, leading to dimerization and formation of an intramolecular disulfide bond between Cys-24 and Cys-59.
uniprot
proteins
protein_family
Chloride channel CLIC family
uniprot
proteins
pubmed
10191309
uniprot
proteins
pubmed
10384126
uniprot
proteins
pubmed
10793131
uniprot
proteins
pubmed
10834939
uniprot
proteins
pubmed
10874038
uniprot
proteins
pubmed
11195932
uniprot
proteins
pubmed
11551966
uniprot
proteins
pubmed
11940526
uniprot
proteins
pubmed
11978800
uniprot
proteins
pubmed
12163479
uniprot
proteins
pubmed
12681486
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14613939
uniprot
proteins
pubmed
14656967
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16339885
uniprot
proteins
pubmed
18850721
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25581026
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
37759794
uniprot
proteins
pubmed
9139710
uniprot
proteins
sequence_length
241
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12681486, ECO:0000269|PubMed:9139710}. Nucleus membrane {ECO:0000269|PubMed:9139710}; Single-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:10793131, ECO:0000269|PubMed:11551966, ECO:0000269|PubMed:12681486, ECO:0000269|PubMed:9139710, ECO:0000305|PubMed:11978800, ECO:0000305|PubMed:14613939}. Cell membrane {ECO:0000269|PubMed:11551966, ECO:0000269|PubMed:11940526, ECO:0000269|PubMed:14613939, ECO:0000305|PubMed:11978800}; Single-pass membrane protein {ECO:0000269|PubMed:11551966, ECO:0000269|PubMed:14613939}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q6MG61}. Note=Mostly in the nucleus including in the nuclear membrane (PubMed:12681486, PubMed:9139710). Small amount in the cytoplasm and the plasma membrane (PubMed:9139710). Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (PubMed:11551966, PubMed:11940526, PubMed:12681486, PubMed:14613939, PubMed:9139710). Might not be present in the nucleus of cardiac cells (By similarity). {ECO:0000250|UniProtKB:Q6MG61, ECO:0000269|PubMed:11551966, ECO:0000269|PubMed:11940526, ECO:0000269|PubMed:12681486, ECO:0000269|PubMed:14613939, ECO:0000269|PubMed:9139710}.
uniprot
proteins
transmembrane_region
TRANSMEM 26..46; /note="Helical; Note=After insertion into the membrane"; /evidence="ECO:0000255
uniprot
proteins