RNF19B
entrez
127544
canonical
uniprot
Q6ZMZ0
canonical
ensembl
ENSG00000116514
resolver
ensp
ENSP00000235150
resolver
ensp
ENSP00000349482
resolver
ensp
ENSP00000362555
resolver
ensp
ENSP00000591652
resolver
ensp
ENSP00000629849
resolver
ensp
ENSP00000629855
resolver
ensp
ENSP00000683726
resolver
genesymbol
RNF19B
resolver
genesymbol_syn
IBRDC3
resolver
genesymbol_syn
NKLAM
resolver
hgnc
HGNC:26886
resolver
uniprot
B7ZLB2
resolver
uniprot
E9PAW6
resolver
uniprot
G3XA82
resolver
uniprot
Q0VG77
resolver
uniprot
Q5TH44
resolver
uniprot
Q5TH45
resolver
uniprot
Q6P6A4
resolver
uniprot
Q8N2S8
resolver
uniprot
Q8WUF3
resolver
uniprot_entry
RN19B_HUMAN
resolver
uniprot_sec
B7ZLB2
resolver
uniprot_sec
E9PAW6
resolver
uniprot_sec
G3XA82
resolver
uniprot_sec
Q0VG77
resolver
uniprot_sec
Q5TH44
resolver
uniprot_sec
Q5TH45
resolver
uniprot_sec
Q6P6A4
resolver
uniprot_sec
Q8N2S8
resolver
uniprot_sec
Q8WUF3
resolver
amino_acid_sequence
MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTLHSVFSASARGRRARAKPQAEPPPPAAQPPPAPAPAAAQGPPPEALPAEPAAEAEAEAAAAAAEPGFDDEEAAEGGGPGAEEVECPLCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLADPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVGISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVSVGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPSIGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLEVQADVQKEIFPKDTASLGAISDNASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHYQLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEEDPPCRHQSCEQKDCLASKPWDISLAQPESIRSDLESSDAQSDDVPDITSDECGSPRSHTAACPSTPRAQGAPSPSAHMNLSALAEGQTVLKPEGGEARV
uniprot
proteins
ec_number
2.3.2.31
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1 (PubMed:16709802, PubMed:27485036). Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells (PubMed:10438909). Protects against staurosporin-induced cell death (PubMed:27485036). {ECO:0000269|PubMed:10438909, ECO:0000269|PubMed:16709802, ECO:0000269|PubMed:27485036}.
uniprot
proteins
mass_dalton
77925
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
RBR family
uniprot
proteins
protein_family
RNF19 subfamily
uniprot
proteins
pubmed
10438909
uniprot
proteins
pubmed
10912506
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16709802
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
27485036
uniprot
proteins
sequence_length
732
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic granule membrane {ECO:0000269|PubMed:10438909}; Multi-pass membrane protein {ECO:0000269|PubMed:10438909}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:27485036}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 354..374; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 415..435; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins