Aqp6
entrez
11831
canonical
uniprot
Q8C4A0
canonical
ensembl
ENSMUSG00000043144
resolver
ensp
ENSMUSP00000023754
resolver
enst
ENSMUST00000023754
resolver
genesymbol
Aqp6
resolver
uniprot_entry
AQP6_MOUSE
resolver
amino_acid_sequence
MEPGLCSRAYLLVGGLWTAISKALFAEFLATGLYVFFGVGSVLPWPVALPSVLQIAITFNLATATAVQISWKTSGAHANPAVTLAYLVGSHISLPRAMAYIAAQLAGATAGAALLYGVTPGGIRETLGVNVVHNSTSTGQAVAVELVLTLQLVLCVFASMDGRQTLASPAAMIGTSVALGHLIGIYFTGCSMNPARSFGPAVIVGKFAVHWIFWVGPLTGAVLASLIYNFILFPDTKTVAQRLAILVGTTKVEKVVDLEPQKKESQTNSEDTECLTSPCEEAVRSFSFTLGLC
uniprot
proteins
function
FUNCTION: Aquaporins form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient. Unlike classical aquaporins, AQP6 is an intracellular channel with selective anion permeability, particularly for nitrate, and exhibits very low water permeability. It may also facilitate the transport of gases, such as CO2 and NH4(+), as demonstrated in vitro. {ECO:0000250|UniProtKB:Q9WTY0}.
uniprot
proteins
mass_dalton
30709
uniprot
proteins
protein_family
MIP/aquaporin (TC 1.A.8) family
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
293
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9WTY0}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..43; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P41181"; TRANSMEM 52..70; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P41181"; TRANSMEM 97..118; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P41181"; TRANSMEM 139..159; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P41181"; TRANSMEM 166..185; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P41181"; TRANSMEM 211..231; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P41181
uniprot
proteins