NRBF2
entrez
29982
canonical
uniprot
Q96F24
canonical
ensembl
ENSG00000148572
resolver
ensp
ENSP00000277746
resolver
ensp
ENSP00000397502
resolver
genesymbol
NRBF2
resolver
genesymbol_syn
COPR
resolver
hgnc
HGNC:19692
resolver
uniprot
A6PW36
resolver
uniprot
B4DWS0
resolver
uniprot
Q86UR2
resolver
uniprot
Q96NP6
resolver
uniprot
Q9H0S9
resolver
uniprot
Q9H2I2
resolver
uniprot_entry
NRBF2_HUMAN
resolver
uniprot_sec
A6PW36
resolver
uniprot_sec
B4DWS0
resolver
uniprot_sec
Q86UR2
resolver
uniprot_sec
Q96NP6
resolver
uniprot_sec
Q9H0S9
resolver
uniprot_sec
Q9H2I2
resolver
amino_acid_sequence
MEVMEGPLNLAHQQSRRADRLLAAGKYEEAISCHKKAAAYLSEAMKLTQSEQAHLSLELQRDSHMKQLLLIQERWKRAQREERLKAQQNTDKDAAAHLQTSHKPSAEDAEGQSPLSQKYSPSTEKCLPEIQGIFDRDPDTLLYLLQQKSEPAEPCIGSKAPKDDKTIIEEQATKIADLKRHVEFLVAENERLRKENKQLKAEKARLLKGPIEKELDVDADFVETSELWSLPPHAETATASSTWQKFAANTGKAKDIPIPNLPPLDFPSPELPLMELSEDILKGFMNN
uniprot
proteins
function
FUNCTION: May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro). {ECO:0000269|PubMed:15610520}.; FUNCTION: Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy (PubMed:24785657). Stabilizes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3 (By similarity). Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1 (PubMed:25086043). May be involved in autophagosome biogenesis (PubMed:25086043). May play a role in neural progenitor cell survival during differentiation (By similarity). {ECO:0000250|UniProtKB:Q8VCQ3, ECO:0000269|PubMed:24785657, ECO:0000269|PubMed:25086043}.
uniprot
proteins
mass_dalton
32378
uniprot
proteins
mutagenesis
MUTAGEN 144..145; /note="LL->AA: Decreased interaction with nuclear receptors."; /evidence="ECO:0000269|PubMed:15610520
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15610520
uniprot
proteins
pubmed
18619852
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22354037
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24785657
uniprot
proteins
pubmed
25086043
uniprot
proteins
sequence_length
287
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9QYK3}. Cytoplasm {ECO:0000250|UniProtKB:Q9QYK3}. Cytoplasmic vesicle {ECO:0000269|PubMed:25086043}. Cytoplasmic vesicle, autophagosome {ECO:0000305}.
uniprot
proteins