Pbx1
entrez
18514
canonical
uniprot
P41778
canonical
ensembl
ENSMUSG00000052534
resolver
ensp
ENSMUSP00000066385
resolver
ensp
ENSMUSP00000134925
resolver
ensp
ENSMUSP00000135516
resolver
ensp
ENSMUSP00000140606
resolver
enst
ENSMUST00000064438
resolver
genesymbol
Pbx1
resolver
genesymbol_syn
PBX1
resolver
genesymbol_syn
PBX1b
resolver
genesymbol_syn
Pbx-1
resolver
uniprot
D9J2V6
resolver
uniprot
H9H9S1
resolver
uniprot
Q71VB4
resolver
uniprot_entry
D9J2V6_MOUSE
resolver
uniprot_entry
H9H9S1_MOUSE
resolver
uniprot_entry
PBX1_MOUSE
resolver
uniprot_entry
Q71VB4_MOUSE
resolver
amino_acid_sequence
MDEQPRLMHSHAGVGMAGHPGLSQHLQDGAGGTEGEGGRKQDIGDILQQIMTITDQSLDEAQARKHALNCHRMKPALFNVLCEIKEKTVLSIRGAQEEEPTDPQLMRLDNMLLAEGVAGPEKGGGSAAAAAAAAASGGAGSDNSVEHSDYRAKLSQIRQIYHTELEKYEQACNEFTTHVMNLLREQSRTRPISPKEIERMVSIIHRKFSSIQMQLKQSTCEAVMILRSRFLDARRKRRNFNKQATEILNEYFYSHLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAAKTAVTATNVSAHGSQANSPSTPNSAGSSSSFNMSNSGDLFMSVQSLNGDSYQGAQVGANVQSQVDTLRHVISQTGGYSDGLAASQMYSPQGISANGGWQDATTPSSVTSPTEGPGSVHSDTSN
uniprot
proteins
function
FUNCTION: Transcription factor which binds the DNA sequence 5'-TGATTGAT-3' as part of a heterodimer with HOX proteins such as HOXA1, HOXA5, HOXB7 and HOXB8 (By similarity). Binds the DNA sequence 5'-TGATTGAC-3' in complex with a nuclear factor which is not a class I HOX protein (By similarity). Has also been shown to bind the DNA sequence 5'-ATCAATCAA-3' cooperatively with HOXA5, HOXB7, HOXB8, HOXC8 and HOXD4 (PubMed:7791786). Acts as a transcriptional activator of PF4 in complex with MEIS1 (By similarity). Also activates transcription of SOX3 in complex with MEIS1 by binding to the 5'-TGATTGAC-3' consensus sequence (PubMed:19799567). In natural killer cells, binds to the NFIL3 promoter and acts as a transcriptional activator of NFIL3, promoting natural killer cell development (PubMed:32190943). Plays a role in the cAMP-dependent regulation of CYP17A1 gene expression via its cAMP-regulatory sequence (CRS1) (PubMed:7913464). Probably in complex with MEIS2, is involved in transcriptional regulation by KLF4 (By similarity). Acts as a transcriptional activator of NKX2-5 and a transcriptional repressor of CDKN2B (PubMed:22560297). Together with NKX2-5, required for spleen development through a mechanism that involves CDKN2B repression (PubMed:22560297). {ECO:0000250|UniProtKB:P40424, ECO:0000269|PubMed:19799567, ECO:0000269|PubMed:22560297, ECO:0000269|PubMed:32190943, ECO:0000269|PubMed:7791786, ECO:0000269|PubMed:7913464}.; FUNCTION: [Isoform PBX1b]: As part of a PDX1:PBX1b:MEIS2B complex in pancreatic acinar cells, is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element. {ECO:0000269|PubMed:11279116}.; FUNCTION: (Microbial infection) In complex with PREP1, binds to the 5'-TGATTGAC-3' consensus sequence in the U5 region of Moloney murine leukemia virus and promotes viral transcription. {ECO:0000269|PubMed:12529389}.
uniprot
proteins
mass_dalton
46626
uniprot
proteins
mutagenesis
MUTAGEN 237; /note="R->A: Slightly reduced binding to NFIL3 promoter."; /evidence="ECO:0000269|PubMed:32190943"; MUTAGEN 286; /note="N->A: Significantly reduced binding to NFIL3 promoter."; /evidence="ECO:0000269|PubMed:32190943"; MUTAGEN 290; /note="R->A: Slightly reduced binding to NFIL3 promoter."; /evidence="ECO:0000269|PubMed:32190943
uniprot
proteins
protein_family
TALE/PBX homeobox family
uniprot
proteins
pubmed
10082572
uniprot
proteins
pubmed
10523646
uniprot
proteins
pubmed
10933814
uniprot
proteins
pubmed
11279116
uniprot
proteins
pubmed
12409300
uniprot
proteins
pubmed
12529389
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19799567
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22560297
uniprot
proteins
pubmed
32190943
uniprot
proteins
pubmed
7791786
uniprot
proteins
pubmed
7913464
uniprot
proteins
pubmed
9315626
uniprot
proteins
pubmed
9525891
uniprot
proteins
pubmed
9710595
uniprot
proteins
sequence_length
430
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:32190943}.
uniprot
proteins