FAAH2
entrez
158584
canonical
uniprot
Q6GMR7
canonical
ensembl
ENSG00000165591
resolver
ensp
ENSP00000364035
resolver
ensp
ENSP00000556093
resolver
ensp
ENSP00000556097
resolver
ensp
ENSP00000598756
resolver
ensp
ENSP00000791325
resolver
ensp
ENSP00000791327
resolver
enst
ENST00000374900
resolver
genesymbol
FAAH2
resolver
genesymbol_syn
AMDD
resolver
hgnc
HGNC:26440
resolver
uniprot
Q86VT2
resolver
uniprot
Q96N98
resolver
uniprot_entry
FAAH2_HUMAN
resolver
uniprot_sec
Q86VT2
resolver
uniprot_sec
Q96N98
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by O-aryl carbamates and alpha-keto heterocytes. {ECO:0000269|PubMed:17015445}.
uniprot
proteins
amino_acid_sequence
MAPSFTARIQLFLLRALGFLIGLVGRAALVLGGPKFASKTPRPVTEPLLLLSGMQLAKLIRQRKVKCIDVVQAYINRIKDVNPMINGIVKYRFEEAMKEAHAVDQKLAEKQEDEATLENKWPFLGVPLTVKEAFQLQGMPNSSGLMNRRDAIAKTDATVVALLKGAGAIPLGITNCSELCMWYESSNKIYGRSNNPYDLQHIVGGSSGGEGCTLAAACSVIGVGSDIGGSIRMPAFFNGIFGHKPSPGVVPNKGQFPLAVGAQELFLCTGPMCRYAEDLAPMLKVMAGPGIKRLKLDTKVHLKDLKFYWMEHDGGSFLMSKVDQDLIMTQKKVVVHLETILGASVQHVKLKKMKYSFQLWIAMMSAKGHDGKEPVKFVDLLGDHGKHVSPLWELIKWCLGLSVYTIPSIGLALLEEKLRYSNEKYQKFKAVEESLRKELVDMLGDDGVFLYPSHPTVAPKHHVPLTRPFNFAYTGVFSALGLPVTQCPLGLNAKGLPLGIQVVAGPFNDHLTLAVAQYLEKTFGGWVCPGKF
uniprot
proteins
ec_number
3.5.1.99
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of endogenous amidated lipids like the sleep-inducing lipid oleamide ((9Z)-octadecenamide), the endocannabinoid anandamide (N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine), as well as other fatty amides, to their corresponding fatty acids, thereby regulating the signaling functions of these molecules (PubMed:17015445, PubMed:19926788). Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates. {ECO:0000269|PubMed:17015445, ECO:0000269|PubMed:19926788}.
uniprot
proteins
mass_dalton
58304
uniprot
proteins
protein_family
Amidase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
17015445
uniprot
proteins
pubmed
19926788
uniprot
proteins
sequence_length
532
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:17015445}; Single-pass membrane protein {ECO:0000305}. Lipid droplet {ECO:0000269|PubMed:19926788}.
uniprot
proteins
transmembrane_region
TRANSMEM 11..31; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins