SH3BGRL
entrez
6451
canonical
uniprot
O75368
canonical
ensembl
ENSG00000131171
resolver
ensp
ENSP00000362308
resolver
enst
ENST00000373212
resolver
genesymbol
HEL-S-115
resolver
genesymbol
SH3BGRL
resolver
genesymbol_syn
SH3BGRL
resolver
hgnc
HGNC:10823
resolver
uniprot
Q3SYL1
resolver
uniprot
Q5JT50
resolver
uniprot
Q6FIE8
resolver
uniprot
Q9H0N8
resolver
uniprot
V9HW48
resolver
uniprot_entry
SH3L1_HUMAN
resolver
uniprot_entry
V9HW48_HUMAN
resolver
uniprot_sec
Q3SYL1
resolver
uniprot_sec
Q5JT50
resolver
uniprot_sec
Q6FIE8
resolver
uniprot_sec
Q9H0N8
resolver
amino_acid_sequence
MVIRVYIASSSGSTAIKKKQQDVLGFLEANKIGFEEKDIAANEENRKWMRENVPENSRPATGYPLPPQIFNESQYRGDYDAFFEARENNAVYAFLGLTAPPGSKEAEVQAKQQA
uniprot
proteins
disease_involvement
DISEASE: Note=Promotes breast cancer progression by enhancing the interaction between E3 ligase STUB1 and PFN1, thereby promoting proteasomal degradation of PFN1 and subsequent activation of downstream signaling pathways including PI3K/AKT, NF-kB and WNT (PubMed:34331014). Promotes autophagy presumably by stabilizing the ubuiquitin-like protein ATG12 (PubMed:34870550). Enhances mRNA translation of E3 ligase STUB1 and the autophagy-related protein PIK3C3 (PubMed:34331014, PubMed:34870550). Promotes activation and phosphorylation of ERBB2 at 'Tyr-877' and 'Tyr-1196', and prolongs localization of ERBB2 to the cell membrane (PubMed:32381043). Breast cancer patients with SH3BGRL overexpression usually experience frequent relapse and poor prognosis (PubMed:32381043, PubMed:34870550). {ECO:0000269|PubMed:32381043, ECO:0000269|PubMed:34331014, ECO:0000269|PubMed:34870550}.
uniprot
proteins
function
FUNCTION: Appears to function as an adapter protein that bridges proteins together or proteins with mRNAs (PubMed:34331014). May function as a ubiquitin ligase-substrate adapter (PubMed:34331014, PubMed:34870550). Additionally, associates with translating cytoplasmic ribosomes and may promote the expression of specific mRNAs (PubMed:34331014, PubMed:34870550). {ECO:0000269|PubMed:34331014, ECO:0000269|PubMed:34870550}.
uniprot
proteins
mass_dalton
12774
uniprot
proteins
protein_family
SH3BGR family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
16080146
uniprot
proteins
pubmed
16511048
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
32381043
uniprot
proteins
pubmed
34331014
uniprot
proteins
pubmed
34870550
uniprot
proteins
pubmed
34930999
uniprot
proteins
pubmed
9642120
uniprot
proteins
sequence_length
114
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:34870550, ECO:0000305|PubMed:34331014}. Cell membrane {ECO:0000269|PubMed:32381043}.
uniprot
proteins