IDO1
entrez
3620
canonical
uniprot
P14902
canonical
ensembl
ENSG00000131203
resolver
ensp
ENSP00000430505
resolver
ensp
ENSP00000430950
resolver
enst
ENST00000518237
resolver
enst
ENST00000522495
resolver
genesymbol
IDO1
resolver
genesymbol_syn
IDO
resolver
genesymbol_syn
INDO
resolver
hgnc
HGNC:6059
resolver
uniprot
A0A348GSI3
resolver
uniprot
E5RGR8
resolver
uniprot
F6M9T7
resolver
uniprot
Q540B4
resolver
uniprot_entry
A0A348GSI3_HUMAN
resolver
uniprot_entry
I23O1_HUMAN
resolver
uniprot_sec
E5RGR8
resolver
uniprot_sec
F6M9T7
resolver
uniprot_sec
Q540B4
resolver
activity_regulation
ACTIVITY REGULATION: Activity is inhibited by and MTH-trp (methylthiohydantoin-DL-tryptophan), modestly inhibited by L-1MT (1-methyl-L-tryptophan) but not D-1MT (1-methyl-D-tryptophan). {ECO:0000269|PubMed:17671174}.
uniprot
proteins
amino_acid_sequence
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
uniprot
proteins
ec_number
1.13.11.52
uniprot
proteins
function
FUNCTION: Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174, PubMed:18026683). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885). Acts as a suppressor of anti-tumor immunity (PubMed:14502282, PubMed:23103127, PubMed:25157255, PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan (PubMed:25691885). Protects the fetus from maternal immune rejection (PubMed:25691885). {ECO:0000269|PubMed:14502282, ECO:0000269|PubMed:17671174, ECO:0000269|PubMed:18026683, ECO:0000303|PubMed:23103127, ECO:0000303|PubMed:25157255, ECO:0000303|PubMed:25691885}.
uniprot
proteins
mass_dalton
45326
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.
uniprot
proteins
protein_family
3-dioxygenase family
uniprot
proteins
protein_family
Indoleamine 2
uniprot
proteins
pubmed
1449503
uniprot
proteins
pubmed
14502282
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
16477023
uniprot
proteins
pubmed
16574111
uniprot
proteins
pubmed
17671174
uniprot
proteins
pubmed
18026683
uniprot
proteins
pubmed
18418598
uniprot
proteins
pubmed
1907934
uniprot
proteins
pubmed
2109605
uniprot
proteins
pubmed
23103127
uniprot
proteins
pubmed
2326172
uniprot
proteins
pubmed
25157255
uniprot
proteins
pubmed
25313323
uniprot
proteins
pubmed
25394548
uniprot
proteins
pubmed
25691885
uniprot
proteins
pubmed
25950090
uniprot
proteins
pubmed
25970480
uniprot
proteins
pubmed
26155395
uniprot
proteins
sequence_length
403
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P28776, ECO:0000303|PubMed:25691885}.
uniprot
proteins