FBXO3
entrez
26273
canonical
uniprot
Q9UK99
canonical
ensembl
ENSG00000110429
resolver
ensp
ENSP00000265651
resolver
ensp
ENSP00000408836
resolver
ensp
ENSP00000434001
resolver
ensp
ENSP00000435165
resolver
ensp
ENSP00000780968
resolver
ensp
ENSP00000780969
resolver
enst
ENST00000531080
resolver
enst
ENST00000532057
resolver
genesymbol
FBXO3
resolver
genesymbol_syn
FBX3
resolver
hgnc
HGNC:13582
resolver
uniprot
B3KY16
resolver
uniprot
D3DR05
resolver
uniprot
F6RXD6
resolver
uniprot
Q49AF1
resolver
uniprot
Q86X90
resolver
uniprot
Q9H0V2
resolver
uniprot
Q9NUX2
resolver
uniprot_entry
F6RXD6_HUMAN
resolver
uniprot_entry
FBX3_HUMAN
resolver
uniprot_entry
Q49AF1_HUMAN
resolver
uniprot_sec
B3KY16
resolver
uniprot_sec
D3DR05
resolver
uniprot_sec
Q86X90
resolver
uniprot_sec
Q9H0V2
resolver
uniprot_sec
Q9NUX2
resolver
amino_acid_sequence
MAAMETETAPLTLESLPTDPLLLILSFLDYRDLINCCYVSRRLSQLSSHDPLWRRHCKKYWLISEEEKTQKNQCWKSLFIDTYSDVGRYIDHYAAIKKAWDDLKKYLEPRCPRMVLSLKEGAREEDLDAVEAQIGCKLPDDYRCSYRIHNGQKLVVPGLLGSMALSNHYRSEDLLDVDTAAGGFQQRQGLKYCLPLTFCIHTGLSQYIAVEAAEGRNKNEVFYQCPDQMARNPAAIDMFIIGATFTDWFTSYVKNVVSGGFPIIRDQIFRYVHDPECVATTGDITVSVSTSFLPELSSVHPPHYFFTYRIRIEMSKDALPEKACQLDSRYWRITNAKGDVEEVQGPGVVGEFPIISPGRVYEYTSCTTFSTTSGYMEGYYTFHFLYFKDKIFNVAIPRFHMACPTFRVSIARLEMGPDEYEEMEEEEEEEEEEDEDDDSADMDESDEDDEEERRRRVFDVPIRRRRCSRLF
uniprot
proteins
function
FUNCTION: Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, SCF(FBXO3), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:18809579, PubMed:26037928). Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome (PubMed:18809579). In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented (PubMed:18809579). PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (PubMed:18809579). The SCF(FBXO3) also acts as a regulator of inflammation by mediating ubiquitination and degradation of FBXL2 in response to lipopolysaccharide (LPS) (PubMed:26037928, PubMed:27010866). The SCF(FBXO3) complex specifically recognizes FBXL2 phosphorylated at 'Thr-404' and promotes its ubiquitination (PubMed:27010866). {ECO:0000250|UniProtKB:Q9DC63, ECO:0000269|PubMed:18809579, ECO:0000269|PubMed:26037928, ECO:0000269|PubMed:27010866}.; FUNCTION: (Microbial infection) Associates with the Rift valley fever virus NSs to form a remodeled E3 ligase that triggers efficient proteasomal degradation of targeted proteins. The filamentous E3 ligase targets the TFIIH complex leading to robust inhibition of antiviral immunity and enhances viral pathogenesis. {ECO:0000269|PubMed:39366381}.
uniprot
proteins
mass_dalton
54561
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:18809579, ECO:0000269|PubMed:26037928}.
uniprot
proteins
pubmed
10531037
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
18809579
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24403578
uniprot
proteins
pubmed
26037928
uniprot
proteins
pubmed
27010866
uniprot
proteins
pubmed
39366381
uniprot
proteins
sequence_length
471
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18809579}. Note=Colocalizes with PML at the peripheries of nuclear bodies. {ECO:0000269|PubMed:18809579}.
uniprot
proteins