TAOK3
entrez
51347
canonical
uniprot
Q9H2K8
canonical
ensembl
ENSG00000135090
resolver
ensp
ENSP00000376317
resolver
ensp
ENSP00000416374
resolver
ensp
ENSP00000443834
resolver
ensp
ENSP00000564401
resolver
ensp
ENSP00000564402
resolver
ensp
ENSP00000564403
resolver
ensp
ENSP00000637818
resolver
ensp
ENSP00000637819
resolver
ensp
ENSP00000637820
resolver
ensp
ENSP00000637821
resolver
ensp
ENSP00000637822
resolver
ensp
ENSP00000647092
resolver
enst
ENST00000392533
resolver
enst
ENST00000419821
resolver
enst
ENST00000537952
resolver
enst
ENST00000894342
resolver
enst
ENST00000894343
resolver
enst
ENST00000894344
resolver
enst
ENST00000967759
resolver
enst
ENST00000967760
resolver
enst
ENST00000967761
resolver
enst
ENST00000967762
resolver
enst
ENST00000967763
resolver
genesymbol
TAOK3
resolver
genesymbol_syn
DPK
resolver
genesymbol_syn
JIK
resolver
genesymbol_syn
KDS
resolver
genesymbol_syn
MAP3K18
resolver
hgnc
HGNC:18133
resolver
uniprot
G3V1Q8
resolver
uniprot
Q658N1
resolver
uniprot
Q8IUM4
resolver
uniprot
Q9HC79
resolver
uniprot
Q9NZM9
resolver
uniprot
Q9UHG7
resolver
uniprot_entry
G3V1Q8_HUMAN
resolver
uniprot_entry
TAOK3_HUMAN
resolver
uniprot_sec
Q658N1
resolver
uniprot_sec
Q8IUM4
resolver
uniprot_sec
Q9HC79
resolver
uniprot_sec
Q9NZM9
resolver
uniprot_sec
Q9UHG7
resolver
amino_acid_sequence
MRKGVLKDPEIADLFYKDDPEELFIGLHEIGHGSFGAVYFATNAHTSEVVAIKKMSYSGKQTHEKWQDILKEVKFLRQLKHPNTIEYKGCYLKEHTAWLVMEYCLGSASDLLEVHKKPLQEVEIAAITHGALHGLAYLHSHALIHRDIKAGNILLTEPGQVKLADFGSASMASPANSFVGTPYWMAPEVILAMDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHIAQNDSPTLQSNEWTDSFRRFVDYCLQKIPQERPTSAELLRHDFVRRDRPLRVLIDLIQRTKDAVRELDNLQYRKMKKILFQETRNGPLNESQEDEEDSEHGTSLNREMDSLGSNHSIPSMSVSTGSQSSSVNSMQEVMDESSSELVMMHDDESTINSSSSVVHKKDHVFIRDEAGHGDPRPEPRPTQSVQSQALHYRNRERFATIKSASLVTRQIHEHEQENELREQMSGYKRMRRQHQKQLIALENKLKAEMDEHRLKLQKEVETHANNSSIELEKLAKKQVAIIEKEAKVAAADEKKFQQQILAQQKKDLTTFLESQKKQYKICKEKIKEEMNEDHSTPKKEKQERISKHKENLQHTQAEEEAHLLTQQRLYYDKNCRFFKRKIMIKRHEVEQQNIREELNKKRTQKEMEHAMLIRHDESTRELEYRQLHTLQKLRMDLIRLQHQTELENQLEYNKRRERELHRKHVMELRQQPKNLKAMEMQIKKQFQDTCKVQTKQYKALKNHQLEVTPKNEHKTILKTLKDEQTRKLAILAEQYEQSINEMMASQALRLDEAQEAECQALRLQLQQEMELLNAYQSKIKMQTEAQHERELQKLEQRVSLRRAHLEQKIEEELAALQKERSERIKNLLERQEREIETFDMESLRMGFGNLVTLDFPKEDYR
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of the MAPK8/JNK cascade and diminishes its activation in response to epidermal growth factor (EGF). Positively regulates canonical T cell receptor (TCR) signaling by preventing early PTPN6/SHP1-mediated inactivation of LCK, ensuring sustained TCR signaling that is required for optimal activation and differentiation of T cells (PubMed:30373850). Phosphorylates PTPN6/SHP1 on 'Thr-394', leading to its polyubiquitination and subsequent proteasomal degradation (PubMed:38166031). Required for cell surface expression of metalloprotease ADAM10 on type 1 transitional B cells which is necessary for their NOTCH-mediated development into marginal zone B cells (By similarity). Also required for the NOTCH-mediated terminal differentiation of splenic conventional type 2 dendritic cells (By similarity). Positively regulates osteoblast differentiation by acting as an upstream activator of the JNK pathway (PubMed:32807497). Promotes JNK signaling in hepatocytes and positively regulates hepatocyte lipid storage by inhibiting beta-oxidation and triacylglycerol secretion while enhancing lipid synthesis (PubMed:34634521). Restricts age-associated inflammation by negatively regulating differentiation of macrophages and their production of pro-inflammatory cytokines (By similarity). Plays a role in negatively regulating the abundance of regulatory T cells in white adipose tissue (By similarity). {ECO:0000250|UniProtKB:Q8BYC6, ECO:0000269|PubMed:10559204, ECO:0000269|PubMed:10924369, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:30373850, ECO:0000269|PubMed:32807497, ECO:0000269|PubMed:34634521, ECO:0000269|PubMed:38166031}.
uniprot
proteins
mass_dalton
105406
uniprot
proteins
mutagenesis
MUTAGEN 165; /note="D->A: Loss of serine/threonine-protein kinase activity."; /evidence="ECO:0000269|PubMed:17396146"; MUTAGEN 181; /note="T->A: No autophosphorylation, no kinase activity and reduced IL2 production by T cells; when associated with F-183."; /evidence="ECO:0000269|PubMed:10559204, ECO:0000269|PubMed:38166031"; MUTAGEN 183; /note="Y->F: No autophosphorylation, no kinase activity and reduced IL2 production by T cells; when associated with A-181."; /evidence="ECO:0000269|PubMed:10559204, ECO:0000269|PubMed:38166031"; MUTAGEN 256; /note="Y->F: Enhances IL2 production by T cells and increases JNK phosphorylation."; /evidence="ECO:0000269|PubMed:38166031"; MUTAGEN 305; /note="Y->F: Enhances IL2 production by T cells and increases JNK phosphorylation."; /evidence="ECO:0000269|PubMed:38166031"; MUTAGEN 324; /note="S->A: Inhibits activation of the p38/MAPK14 stress-activated MAPK cascade in response to DNA damage. Enhances IL2 production by T cells."; /evidence="ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:38166031
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated (PubMed:10559204). Phosphorylation at Ser-324 by ATM following DNA damage is required for activation of the p38/MAPK14 stress-activated MAPK cascade (PubMed:17396146). Phosphorylated at Ser-324 and on Tyr residues during T cell activation (PubMed:30373850). Phosphorylated by LRRK2 (PubMed:20949042). {ECO:0000269|PubMed:10559204, ECO:0000269|PubMed:17396146, ECO:0000269|PubMed:20949042, ECO:0000269|PubMed:30373850}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
protein_family
STE20 subfamily
uniprot
proteins
pubmed
10559204
uniprot
proteins
pubmed
10924369
uniprot
proteins
pubmed
11278723
uniprot
proteins
pubmed
13679851
uniprot
proteins
pubmed
14996095
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17396146
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20949042
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22202175
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
30373850
uniprot
proteins
pubmed
32807497
uniprot
proteins
pubmed
34634521
uniprot
proteins
pubmed
38166031
uniprot
proteins
sequence_length
898
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:13679851}. Cell membrane {ECO:0000269|PubMed:13679851}; Peripheral membrane protein {ECO:0000269|PubMed:13679851}. Membrane raft {ECO:0000269|PubMed:30373850}. Lipid droplet {ECO:0000269|PubMed:34634521}. Note=Located primarily outside cell membrane rafts and remains outside upon canonical TCR ligation (PubMed:30373850). A small pool is detectable in cell membrane rafts in resting conditions but relocates outside the rafts upon TCR signaling (PubMed:30373850). Localizes to lipid droplets in hepatocytes (PubMed:34634521). {ECO:0000269|PubMed:30373850, ECO:0000269|PubMed:34634521}.
uniprot
proteins