TRIM3
entrez
10612
canonical
uniprot
O75382
canonical
ensembl
ENSG00000110171
resolver
ensp
ENSP00000340797
resolver
ensp
ENSP00000352508
resolver
ensp
ENSP00000433102
resolver
ensp
ENSP00000445460
resolver
genesymbol
TRIM3
resolver
genesymbol_syn
BERP
resolver
genesymbol_syn
RNF22
resolver
genesymbol_syn
RNF97
resolver
hgnc
HGNC:10064
resolver
uniprot
B7Z5E6
resolver
uniprot
B7Z5Y8
resolver
uniprot
F5H2Q8
resolver
uniprot
Q4V9L4
resolver
uniprot
Q9C038
resolver
uniprot
Q9C039
resolver
uniprot_entry
B7Z5Y8_HUMAN
resolver
uniprot_entry
TRIM3_HUMAN
resolver
uniprot_sec
B7Z5E6
resolver
uniprot_sec
F5H2Q8
resolver
uniprot_sec
Q4V9L4
resolver
uniprot_sec
Q9C038
resolver
uniprot_sec
Q9C039
resolver
amino_acid_sequence
MAKREDSPGPEVQPMDKQFLVCSICLDRYQCPKVLPCLHTFCERCLQNYIPAQSLTLSCPVCRQTSILPEQGVSALQNNFFISSLMEAMQQAPDGAHDPEDPHPLSVVAGRPLSCPNHEGKTMEFYCEACETAMCGECRAGEHREHGTVLLRDVVEQHKAALQRQLEAVRGRLPQLSAAIALVGGISQQLQERKAEALAQISAAFEDLEQALQQRKQALVSDLETICGAKQKVLQSQLDTLRQGQEHIGSSCSFAEQALRLGSAPEVLLVRKHMRERLAALAAQAFPERPHENAQLELVLEVDGLRRSVLNLGALLTTSATAHETVATGEGLRQALVGQPASLTVTTKDKDGRLVRTGSAELRAEITGPDGTRLPVPVVDHKNGTYELVYTARTEGELLLSVLLYGQPVRGSPFRVRALRPGDLPPSPDDVKRRVKSPGGPGSHVRQKAVRRPSSMYSTGGKRKDNPIEDELVFRVGSRGREKGEFTNLQGVSAASSGRIVVADSNNQCIQVFSNEGQFKFRFGVRGRSPGQLQRPTGVAVDTNGDIIVADYDNRWVSIFSPEGKFKTKIGAGRLMGPKGVAVDRNGHIIVVDNKSCCVFTFQPNGKLVGRFGGRGATDRHFAGPHFVAVNNKNEIVVTDFHNHSVKVYSADGEFLFKFGSHGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDSSGSFLSYINTSAEPLYGPQGLALTSDGHVVVADAGNHCFKAYRYLQ
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase that plays essential roles in neuronal functions such as regulation of neuronal plasticity, learning, and memory (By similarity). In addition to its neuronal functions, participates in other biological processes such as innate immunity or cell cycle regulation. Component of the cytoskeleton-associated recycling or transport complex in neurons, polyubiquitinates gamma-actin, thus regulating neuronal plasticity, learning, and memory (By similarity). Ubiquitinates postsynaptic scaffold GKAP, a neuronal substrate involved in synaptic remodeling and thereby modulates dendritic spine morphology (By similarity). Positively regulates motility of microtubule-dependent motor protein KIF21B (By similarity). Induces growth arrest via its RING-dependent E3 ligase activity and ubiquitinates CDKN1A (PubMed:24393003). Positively regulates TLR3-mediated signaling by mediating 'Lys-63'-linked polyubiquitination of TLR3 (PubMed:32878999). In turn, promotes the recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes (PubMed:32878999). {ECO:0000250|UniProtKB:Q9R1R2, ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:24393003, ECO:0000269|PubMed:32878999}.
uniprot
proteins
mass_dalton
80830
uniprot
proteins
mutagenesis
MUTAGEN 22; /note="C->S: Strong loss of ubiquitin ligase activity; when associated with S-25."; /evidence="ECO:0000269|PubMed:24393003, ECO:0000269|PubMed:32878999"; MUTAGEN 25; /note="C->S: Strong loss of ubiquitin ligase activity; when associated with S-22."; /evidence="ECO:0000269|PubMed:24393003, ECO:0000269|PubMed:32878999
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
11170753
uniprot
proteins
pubmed
11331580
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772161
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19460345
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24393003
uniprot
proteins
pubmed
32878999
uniprot
proteins
pubmed
36481767
uniprot
proteins
sequence_length
744
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:36481767}. Early endosome {ECO:0000269|PubMed:15772161, ECO:0000269|PubMed:32878999}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:32878999}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9R1R2}. Note=Mainly located in the Golgi apparatus and transported to the early endosomes upon stimulation with dsRNA. {ECO:0000269|PubMed:32878999}.
uniprot
proteins