Dusp6
entrez
116663
canonical
uniprot
Q64346
canonical
ensembl
ENSRNOG00000023896
resolver
ensembl
ENSRNOG00055005953
resolver
ensembl
ENSRNOG00060005287
resolver
ensembl
ENSRNOG00065012222
resolver
ensp
ENSRNOP00000032969
resolver
ensp
ENSRNOP00000087245
resolver
ensp
ENSRNOP00055007467
resolver
ensp
ENSRNOP00060006652
resolver
ensp
ENSRNOP00065015227
resolver
enst
ENSRNOT00000037844
resolver
enst
ENSRNOT00000111909
resolver
enst
ENSRNOT00055009660
resolver
enst
ENSRNOT00060008815
resolver
enst
ENSRNOT00065019869
resolver
genesymbol
Dusp6
resolver
genesymbol_syn
Mkp3
resolver
uniprot
A0A8L2QHD1
resolver
uniprot_entry
A0A8L2QHD1_RAT
resolver
uniprot_entry
DUS6_RAT
resolver
amino_acid_sequence
MIDTLRPVPFASEMAISKTVAWLNEQLELGNEQLLLMDCRPQELYESSHIESAINVAIPGIMLRRLQKGNLPVRALFTRCEDRDRFTRRCGTDTVVLYDENSSDWNENTGGESVLGLLLKKLKDEGCRAFYLEGGFSKFQAEFALHCETNLDGSCSSSSPPLPVLGLGGLRISSDSSSDIESDLDRDPNSATDSDGSPLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLSSPCDNRVPAQQLYFTAPSNQNVYQVDSLQST
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Dual specificity protein phosphatase, which mediates dephosphorylation and inactivation of MAP kinases (PubMed:8626780). Has a specificity for the ERK family (PubMed:8626780). Implicated in muscle and neuronal differentiation (PubMed:8631996). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (By similarity). {ECO:0000250|UniProtKB:Q9DBB1, ECO:0000269|PubMed:8626780, ECO:0000269|PubMed:8631996}.
uniprot
proteins
mass_dalton
42319
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the SCF(FBXO31) complex, leading to its proteasomal degradation. {ECO:0000250|UniProtKB:Q16828}.
uniprot
proteins
protein_family
Non-receptor class dual specificity subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8626780
uniprot
proteins
pubmed
8631996
uniprot
proteins
sequence_length
381
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8626780}.
uniprot
proteins