Scn1a
entrez
81574
canonical
uniprot
P04774
canonical
ensembl
ENSRNOG00000053122
resolver
ensp
ENSRNOP00000073986
resolver
enst
ENSRNOT00000091259
resolver
genesymbol
Scn1a
resolver
uniprot
A0A0G2K6Y2
resolver
uniprot_entry
A0A0G2K6Y2_RAT
resolver
uniprot_entry
SCN1A_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by the spider toxins Hm1a and Hm1b (H.maculata, AC P60992 and AC P0DOC5) eliciting acute pain and mechanical allodynia (By similarity). Inhibited by the conotoxin GVIIJ (PubMed:24497506). {ECO:0000250|UniProtKB:A2APX8, ECO:0000269|PubMed:24497506}.
uniprot
proteins
amino_acid_sequence
MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPKPNSDLEAGKNLPFIYGDIPPEMVSEPLEDLDPYYINKKTFIVLNKGKAIFRFSATSALYILTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTMSNPPDWTKNVEYTFTGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVQWPPTNASLEEHSIEKNVTTDYNGTLVNETVFEFDWKSYIQDSRYHYFLEGVLDALLCGNSSDAGQCPEGYMCVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTYMIFFVLVIFLGSFYLINLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEAAQQAAAATASEHSREPSAAGRLSDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDDDEFHKSESEDSIRRKGFRFSIEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTFEDNESRRDSLFVPRRHGERRNSNLSQTSRSSRMLAGLPANGKMHSTVDCNGVVSLVGGPSVPTSPVGQLLPEVIIDKPATDDNGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEELEESRQKCPPCWYKFSNIFLIWDCSPYWLKVKHIVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEHFNHVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVEGLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKIATDCKLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLTVFMMVMVIRNLVVLNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRKIYEFIQQSFVRKQKILDEIKPLDDLNNRKDNCTSNHTTEIGKDLDCLKDVNGTTSGIGTGSSVEKYIIDESDYMSFINNPSLTVTVPIAVGESDFENLNTEDFSSESDLEESKEKLNESSSSSEGSTVDIGAPAEEQPVMEPEETLEPEACFTEGCVQRFKCCQISVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYIDQRKTIKTMLEYADKVFTYIFILEMLLKWVAYGYQTYFTNAWCWLDFLIVDVSLVSLTANALGYSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHCVNTTTGDTFEITEVNNHSDCLKLIERNETARWKNVKVNFDNVGFGYLSLLQVATFKGWMDIMYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQSDYVTSILSRINLVFIVLFTGECVLKLISLRHYYFTIGWNIFDFVVVILSIVGMFLAELIEKYFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKREVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQPNKLQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDALRIQMEERFMASNPSKVSYQPITTTLKRKQEEVSAVIIQRAYRRHLLKRTVKQASFTYNKNKLKGGANLLVKEDMIIDRINENSITEKTDLTMSTAACPPSYDRVTKPIVEKHEQEGKDEKAKGK
uniprot
proteins
function
FUNCTION: Pore-forming subunit of Nav1.1, a voltage-gated sodium (Nav) channel that directly mediates the depolarizing phase of action potentials in excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na(+) ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (By similarity). By regulating the excitability of neurons, ensures that they respond appropriately to synaptic inputs, maintaining the balance between excitation and inhibition in brain neural circuits. Nav1.1 plays a role in controlling the excitability and action potential propagation from somatosensory neurons, thereby contributing to the sensory perception of mechanically-induced pain (By similarity). {ECO:0000250|UniProtKB:A2APX8, ECO:0000250|UniProtKB:P35498}.
uniprot
proteins
mass_dalton
228770
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-1516 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents. {ECO:0000250|UniProtKB:P04775}.
uniprot
proteins
protein_family
Nav1.1/SCN1A subfamily
uniprot
proteins
protein_family
Sodium channel (TC 1.A.1.10) family
uniprot
proteins
pubmed
1658739
uniprot
proteins
pubmed
20131913
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2442385
uniprot
proteins
pubmed
24497506
uniprot
proteins
pubmed
3754035
uniprot
proteins
sequence_length
2009
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P35498}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P35498}.
uniprot
proteins
transmembrane_region
TRANSMEM 129..146; /note="Helical; Name=S1 of repeat I"; /evidence="ECO:0000250|UniProtKB:P35498"; TRANSMEM 153..177; /note="Helical; Name=S2 of repeat I"; /evidence="ECO:0000250|UniProtKB:P35498"; TRANSMEM 189..205; /note="Helical; Name=S3 of repeat I"; /evidence="ECO:0000250|UniProtKB:P35498"; TRANSMEM 214..235; /note="Helical; Name=S4 of repeat I"; /evidence="ECO:0000250|UniProtKB:P35498"; TRANSMEM 246..269; /note="Helical; Name=S5 of repeat I"; /evidence="ECO:0000250|UniProtKB:P35498"; TRANSMEM 398..423; /note="Helical; Name=S6 of repeat I"; /evidence="ECO:0000250|UniProtKB:P35498"; TRANSMEM 769..787; /note="Helical; Name=S1 of repeat II"; /evidence="ECO:0000250|UniProtKB:P35498"; TRANSMEM 798..820; /note="Helical; Name=S2 of repeat II"; /evidence="ECO:0000250|UniProtKB:P35498"; TRANSMEM 831..849; /note="Helical; Name=S3 of repeat II"; /evidence="ECO:0000250|UniProtKB:P35498"; TRANSMEM 855..874; /note="Helical; Name=S4 of repeat II"; /evidence="ECO:0000250|UniProtKB:P35498"; TRANSMEM 892..912; /note="Helical; Name=S5 of repeat II"; /evidence="ECO:0000250|UniProtKB:P35498"; TRANSMEM 966..992; /note="Helical; Name=S6 of repeat II"; /evidence="ECO:0000250|UniProtKB:P35498"; TRANSMEM 1219..1237; /note="Helical; Name=S1 of repeat III"; /evidence="ECO:0000250|UniProtKB:P35498"; TRANSMEM 1251..1276; /note="Helical; Name=S2 of repeat III"; /evidence="ECO:0000250|UniProtKB:P35498"; TRANSMEM 1279..1304; /note="Helical; Name=S3 of repeat III"; /evidence="ECO:0000250|UniProtKB:P35498"; TRANSMEM 1314..1332; /note="Helical; Name=S4 of repeat III"; /evidence="ECO:0000250|UniProtKB:P35498"; TRANSMEM 1346..1369; /note="Helical; Name=S5 of repeat III"; /evidence="ECO:0000250|UniProtKB:P35498"; TRANSMEM 1458..1483; /note="Helical; Name=S6 of repeat III"; /evidence="ECO:0000250|UniProtKB:P35498"; TRANSMEM 1542..1560; /note="Helical; Name=S1 of repeat IV"; /evidence="ECO:0000250|UniProtKB:P35498"; TRANSMEM 1572..1593; /note="Helical; Name=S2 of repeat IV"; /evidence="ECO:0000250|UniProtKB:P35498"; TRANSMEM 1602..1623; /note="Helical; Name=S3 of repeat IV"; /evidence="ECO:0000250|UniProtKB:P35498"; TRANSMEM 1637..1655; /note="Helical; Name=S4 of repeat IV"; /evidence="ECO:0000250|UniProtKB:P35498"; TRANSMEM 1666..1688; /note="Helical; Name=S5 of repeat IV"; /evidence="ECO:0000250|UniProtKB:P35498"; TRANSMEM 1760..1788; /note="Helical; Name=S6 of repeat IV"; /evidence="ECO:0000250|UniProtKB:P35498
uniprot
proteins