Scn1b
entrez
29686
canonical
uniprot
Q00954
canonical
ensembl
ENSRNOG00000021102
resolver
ensembl
ENSRNOG00055032690
resolver
ensembl
ENSRNOG00060032696
resolver
ensembl
ENSRNOG00065033819
resolver
ensp
ENSRNOP00000028653
resolver
ensp
ENSRNOP00000070450
resolver
ensp
ENSRNOP00055046607
resolver
ensp
ENSRNOP00060046858
resolver
ensp
ENSRNOP00065047820
resolver
enst
ENSRNOT00000028653
resolver
enst
ENSRNOT00055056501
resolver
enst
ENSRNOT00060056693
resolver
enst
ENSRNOT00065058089
resolver
genesymbol
Scn1b
resolver
genesymbol_syn
SCN1B
resolver
uniprot
Q505J0
resolver
uniprot
Q9QXU3
resolver
uniprot_entry
Q9QXU3_RAT
resolver
uniprot_entry
SCN1B_RAT
resolver
uniprot_sec
Q505J0
resolver
amino_acid_sequence
MGTLLALVVGAVLVSSAWGGCVEVDSETEAVYGMTFKILCISCKRRSETTAETFTEWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYECHVYRLLFFDNYEHNTSVVKKIHLEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMVYCYKKIAAATEAAAQENASEYLAITSESKENCTGVQVAE
uniprot
proteins
function
FUNCTION: Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes (By similarity). Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient (By similarity). The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues (By similarity). The accessory beta subunits participate in localization and functional modulation of the Nav channels (PubMed:1375395, PubMed:15178439, PubMed:28012039, PubMed:8021275, PubMed:8282123). Modulates the activity of SCN1A/Nav1.1, SCN2A/Nav1.2, SCN3A/Nav1.3, SCN4A/Nav1.4, SCN5A/Nav1.5, SCN8A/Nav1.6, SCN9A/Nav1.7 and SCN10A/Nav1.8 (By similarity) (PubMed:1375395, PubMed:15178439, PubMed:28012039, PubMed:8021275, PubMed:8282123). {ECO:0000250|UniProtKB:Q07699, ECO:0000269|PubMed:1375395, ECO:0000269|PubMed:15178439, ECO:0000269|PubMed:28012039, ECO:0000269|PubMed:8021275, ECO:0000269|PubMed:8282123}.
uniprot
proteins
mass_dalton
24692
uniprot
proteins
mutagenesis
MUTAGEN 109..110; /note="TN->AA: Strongly decreased ability to mediate rapid channel inactivation."; /evidence="ECO:0000269|PubMed:28012039
uniprot
proteins
protein_family
Sodium channel auxiliary subunit SCN1B (TC 8.A.17) family
uniprot
proteins
pubmed
11470829
uniprot
proteins
pubmed
1375395
uniprot
proteins
pubmed
15178439
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22425777
uniprot
proteins
pubmed
28012039
uniprot
proteins
pubmed
8021275
uniprot
proteins
pubmed
8282123
uniprot
proteins
sequence_length
218
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11470829}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q07699}. Perikaryon {ECO:0000250|UniProtKB:P97952}. Cell projection {ECO:0000250|UniProtKB:P97952}. Cell projection, axon {ECO:0000269|PubMed:11470829}. Note=Detected at nodes of Ranvier on the sciatic nerve. {ECO:0000269|PubMed:11470829}.
uniprot
proteins
transmembrane_region
TRANSMEM 158..179; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q07699
uniprot
proteins