ENTREP1
entrez
9413
canonical
uniprot
Q15884
canonical
ensembl
ENSG00000135063
resolver
ensp
ENSP00000257515
resolver
ensp
ENSP00000304435
resolver
ensp
ENSP00000395675
resolver
ensp
ENSP00000581557
resolver
ensp
ENSP00000700501
resolver
ensp
ENSP00000700502
resolver
ensp
ENSP00000700509
resolver
genesymbol
ENTREP1
resolver
genesymbol_syn
C9orf61
resolver
genesymbol_syn
FAM189A2
resolver
genesymbol_syn
X123
resolver
hgnc
HGNC:24820
resolver
uniprot
A0A0A0MR12
resolver
uniprot
A0A6F8PH59
resolver
uniprot
Q14CN5
resolver
uniprot
Q5T6C8
resolver
uniprot
Q5T6C9
resolver
uniprot
Q6ZTX4
resolver
uniprot
Q8WU02
resolver
uniprot
Q96N10
resolver
uniprot_entry
EREP1_HUMAN
resolver
uniprot_entry
Q8WU02_HUMAN
resolver
uniprot_sec
A0A0A0MR12
resolver
uniprot_sec
A0A6F8PH59
resolver
uniprot_sec
Q14CN5
resolver
uniprot_sec
Q5T6C8
resolver
uniprot_sec
Q5T6C9
resolver
uniprot_sec
Q6ZTX4
resolver
uniprot_sec
Q96N10
resolver
amino_acid_sequence
MILLVNLFVLLSVVCVLLNLAGFILGCQGAQFVSSVPRCDLVDLGEGKICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAALRYLQIFATRRSCIDESQISAEEAEDHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRMVGPDVIPLPHIYGARIKGVEVFCPLDPPPPYEAVVSQMDQEQGSSFQMSEGSEAAVIPLDLGCTQVTQDGDIPNIPAEENASTSTPSSTLVRPIRSRRALPPLRTRSKSDPVLHPSEERAAPVLSCEAATQTERRLDLAAVTLRRGLRSRASRCRPRSLIDYKSYMDTKLLVARFLEQSSCTMTPDIHELVENIKSVLKSDEEHMEEAITSASFLEQIMAPLQPSTSRAHKLPSRRQPGLLHLQSCGDLHTFTPAGRPRAERRPRRVEAERPHSLIGVIRETVL
uniprot
proteins
function
FUNCTION: Functions as an activator of the E3 ubiquitin protein ligase ITCH in the ubiquitination of the CXCL12-activated CXCR4 receptor. Thereby, triggers CXCR4 endocytosis and desensitization, negatively regulating the CXCL12/CXCR4 signaling pathway. {ECO:0000269|PubMed:34927784}.
uniprot
proteins
mass_dalton
49703
uniprot
proteins
mutagenesis
MUTAGEN 151; /note="Y->A: Decreased interaction with ITCH and no effect on interaction with EPN1; when associated with A-197."; /evidence="ECO:0000269|PubMed:34927784"; MUTAGEN 197; /note="Y->A: Decreased interaction with ITCH and no effect on interaction with EPN1; when associated with A-151."; /evidence="ECO:0000269|PubMed:34927784
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated at Lys-274, Lys-329 and Lys-365 by ITCH. {ECO:0000269|PubMed:34927784}.
uniprot
proteins
protein_family
ENTREP family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
34927784
uniprot
proteins
pubmed
7951235
uniprot
proteins
sequence_length
450
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:34927784}; Single-pass type I membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:34927784}; Single-pass type I membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000269|PubMed:34927784}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:34927784}; Single-pass type I membrane protein {ECO:0000255}. Note=Enriched in endosomes compared to the cell membrane. {ECO:0000269|PubMed:34927784}.
uniprot
proteins
transmembrane_region
TRANSMEM 86..106; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins