Q5DU05
uniprot
Q5DU05
canonical
amino_acid_sequence
MARRPILLGDQLVLEEDSDETYVPSEQEILDFARVIGIDPIKEPELMWLAREGIEAPLPKGWKPCQNITGDLYYFNFDTGQSIWDHPCDEHYRKLVIQERERWSAPGAIKKKDKKKKKEKKNKKDKETSKSPLVLGSPLALVQAPLWGLAPLRGLGDAPPSALRGSQSVSLGSSADSGHLGEPTLPPQGLKAAACAKGLLASVHEGKNALSLLTLGEETNEEDEEESDNQSVRSSSELLKNLHLDLGALGGNFEYEESPRTSQPDKKDVSLDSDADRPPTPGKLFSQGADSSVASANGSKSQGRGASPWNPQKENENSDPKASSSQMAPELDPGGDQPSRASKKQQAEDPVQAGKEGECRRESAAKEPKEASALENTSDVSEESEIHGHLKDARHSGSEASGPKSFLGLDLGFRSRISEHLLDGDTLSPVLGGGHWEAQGLDQEEQDDSKSSIAEPQSKHTQGSEREHLQSSLHSQATEEGPLQTLEGQPEWKEAEGPGKDSVASPAPLSLLQREQVLSPPASPERAEEKHSQAEELGLEQPEAEETEEKVAVCPSSPVSPEVQTAEPAAPQKLFSEAILKGMELEEDQRLLLEFQKEKPQQLEERLWEEEEEEVCQLYQQKEKSLSLLKAQLQKATAEEKEKEEETKIREEESRRLVCLRAQVQSRTEAFENQIRTEQQAALQRLREEAETLQKAERASLEQKSRRALEQLREQLEAEERSAQAALRAEKEAEKEAALLQLREQLEGERKEAVAGLEKKHSAELEQLCSSLEAKHQEVISSLQKKIEGAQQKEEAQLQESLGWAEQRAHQKVHQVTEYEQELSSLLRDKRQEVEREHERKMDKMKEEHWQEMADARERYEAEERKQRADLLGHLTGELERLRRAHERELESMRQEQDQQLEDLRRRHRDHERKLQDLEVELSSRTKDVKARLAQLNVQEENIRKEKQLLLDAQRQAALEREEATATHQHLEEAKKEHTHLLETKQQLRRTIDDLRVRRVELESQVDLLQAQSQRLQKHLSSLEAEVQRKQDVLKEMAAEMNASPHPEPGLHIEDLRKSLDTNKNQEVSSSLSLSKEEIDLSMESVRQFLSAEGVAVRNAKEFLVRQTRSMRRRQTALKAAQQHWRHELASAQEVDEDLPGTEVLGNMRKNLNEETRHLDEMKSAMRKGHDLLKKKEEKLIQLESSLQEEVSDEDTLKGSSIKKVTFDLSDMDDLSSESLESSPVLHITPTPTSADPNKIHYLSSSLQRISSELNGVLNVLGSLNSQPPPQGLGSQPPPPLFTSSLRSSKNVLDPAYSSQAKLSSLSSITPMSTQWAWDPGQGTKLTSSSSSQTVDDFLLEKWRKYFPSGIPLLSGSPPPPENKLGYVSVSEQLHFLQRSHPRVPRTDGVSIQSLIDSNRKWLEHFRNDPKVQLFSSAPKATTTSNLSNLLQLGLDENNRLNVFHY
uniprot
proteins
function
FUNCTION: Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:22863007}.
uniprot
proteins
mass_dalton
162601
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22863007
uniprot
proteins
pubmed
23955340
uniprot
proteins
pubmed
26337392
uniprot
proteins
sequence_length
1446
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:22863007, ECO:0000269|PubMed:26337392}. Nucleus {ECO:0000250|UniProtKB:Q9UPV0}. Note=Localizes specifically to very distally located appendage structures on the mature centriole from which initiate PC formation (PubMed:26337392). Persisted at centrioles throughout mitosis (By similarity). In response to DNA damage, it translocates to nuclear foci that contain the DNA damage response proteins KAT5/TIP60 and CHEK1 (By similarity). {ECO:0000250|UniProtKB:Q9UPV0, ECO:0000269|PubMed:26337392}.
uniprot
proteins