Irak1
entrez
16179
canonical
uniprot
Q62406
canonical
ensembl
ENSMUSG00000031392
resolver
ensp
ENSMUSP00000033769
resolver
ensp
ENSMUSP00000064448
resolver
ensp
ENSMUSP00000109992
resolver
ensp
ENSMUSP00000109994
resolver
ensp
ENSMUSP00000110000
resolver
enst
ENSMUST00000033769
resolver
enst
ENSMUST00000114354
resolver
genesymbol
Irak1
resolver
genesymbol_syn
Il1rak
resolver
uniprot
B1AUW4
resolver
uniprot
B1AUW6
resolver
uniprot
F6W7R3
resolver
uniprot
Q540G0
resolver
uniprot
Q6Y3Z5
resolver
uniprot
Q6Y3Z6
resolver
uniprot
Q8BR10
resolver
uniprot_entry
B1AUW6_MOUSE
resolver
uniprot_entry
F6W7R3_MOUSE
resolver
uniprot_entry
IRAK1_MOUSE
resolver
uniprot_entry
Q540G0_MOUSE
resolver
uniprot_entry
Q8BR10_MOUSE
resolver
uniprot_sec
B1AUW4
resolver
uniprot_sec
Q6Y3Z5
resolver
uniprot_sec
Q6Y3Z6
resolver
amino_acid_sequence
MAGGPGPGEPVVPGAQHFLYEVPPWVMCRFYKVMDALEPADWCQFAALIVRDQTELRLCERSEQRTASVLWPWINRNARVADLVHILTHLQLLRARDIITAWHPPAPVVPPSTAAPRPSSISAGSEAGDWSPRKLQSSASTFLSPAFPGSQTHSESELLQVPLPVSLGPPLPSSAPSSTKSSPESPVSGLQRAHPSPFCWPFCEISQGTCNFSEELRIGEGGFGCVYRAVMRNTTYAVKRLKEEADLEWTMVKQSFLTEVEQLSRFRHPNIVDFAGYCAESGLYCLVYGFLPNGSLEDQLHLQTQACSPLSWPQRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLMPKLGDFGLARFSRFAGAKASQSSTVARTSTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVILETLAGQRAVRTQGAKTKYLKDLIEDEAEEAGVTLKSTQPTLWVGVATDAWAAPIAAQIYKKHLDSRPGPCPPQLGLALAQLACCCMHRRAKKRPPMTQVYKRLEGLQAGPPWELEVAGHGSPSPQENSYMSTTGSAQSGDEPWQPLVVTTRAPAQAAQQLQRSPNQPVESDESVPGLSATLHSWHLTPGSHPSPASFREASCTQGGTTRESSVRSSPGFQPTTMEGSPTGSSSLLSSEPPQIIINPARQKMVQKLALYEEGVLDSLQLLSSGFFPGLDLEPEKSQGPEESDEFQS
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3 (By similarity). {ECO:0000250, ECO:0000269|PubMed:8663605}.
uniprot
proteins
mass_dalton
77269
uniprot
proteins
mutagenesis
MUTAGEN 66; /note="T->A: Abolishes dimerization."; /evidence="ECO:0000269|PubMed:12138165"; MUTAGEN 66; /note="T->E: Abolishes dimerization."; /evidence="ECO:0000269|PubMed:12138165
uniprot
proteins
post_translational_modification
PTM: Following recruitment on the activated receptor complex, phosphorylated on Thr-209, probably by IRAK4, resulting in a conformational change of the kinase domain, allowing further phosphorylations to take place. Thr-387 phosphorylation in the activation loop is required to achieve full enzymatic activity (By similarity). {ECO:0000250}.; PTM: Polyubiquitinated by TRAF6 after cell stimulation with IL-1-beta by PELI1, PELI2 and PELI3. Polyubiquitination occurs with polyubiquitin chains linked through 'Lys-63'. Ubiquitination promotes interaction with NEMO/IKBKG. Also sumoylated; leading to nuclear translocation (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Pelle subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
TKL Ser/Thr protein kinase family
uniprot
proteins
pubmed
10723722
uniprot
proteins
pubmed
11096118
uniprot
proteins
pubmed
12138165
uniprot
proteins
pubmed
12370331
uniprot
proteins
pubmed
15767370
uniprot
proteins
pubmed
16951688
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21435586
uniprot
proteins
pubmed
22037600
uniprot
proteins
pubmed
8663605
uniprot
proteins
sequence_length
710
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Lipid droplet {ECO:0000269|PubMed:21435586}. Note=Translocates to the nucleus when sumoylated (By similarity). RSAD2/viperin recruits it to the lipid droplet. {ECO:0000250}.
uniprot
proteins