CPNE1
entrez
8904
canonical
uniprot
Q99829
canonical
ensembl
ENSG00000214078
resolver
ensp
ENSP00000317257
resolver
ensp
ENSP00000336945
resolver
ensp
ENSP00000380585
resolver
ensp
ENSP00000415597
resolver
ensp
ENSP00000549810
resolver
ensp
ENSP00000549811
resolver
ensp
ENSP00000643402
resolver
ensp
ENSP00000643403
resolver
ensp
ENSP00000768118
resolver
enst
ENST00000317677
resolver
enst
ENST00000352393
resolver
enst
ENST00000397443
resolver
enst
ENST00000879751
resolver
enst
ENST00000879752
resolver
genesymbol
CPNE1
resolver
genesymbol_syn
CPN1
resolver
hgnc
HGNC:2314
resolver
uniprot
B0QZ18
resolver
uniprot
E1P5Q4
resolver
uniprot
Q6IBL3
resolver
uniprot
Q9H243
resolver
uniprot
Q9NTZ7
resolver
uniprot_entry
B0QZ18_HUMAN
resolver
uniprot_entry
CPNE1_HUMAN
resolver
uniprot_sec
E1P5Q4
resolver
uniprot_sec
Q6IBL3
resolver
uniprot_sec
Q9H243
resolver
uniprot_sec
Q9NTZ7
resolver
amino_acid_sequence
MAHCVTLVQLSISCDHLIDKDIGSKSDPLCVLLQDVGGGSWAELGRTERVRNCSSPEFSKTLQLEYRFETVQKLRFGIYDIDNKTPELRDDDFLGGAECSLGQIVSSQVLTLPLMLKPGKPAGRGTITVSAQELKDNRVVTMEVEARNLDKKDFLGKSDPFLEFFRQGDGKWHLVYRSEVIKNNLNPTWKRFSVPVQHFCGGNPSTPIQVQCSDYDSDGSHDLIGTFHTSLAQLQAVPAEFECIHPEKQQKKKSYKNSGTIRVKICRVETEYSFLDYVMGGCQINFTVGVDFTGSNGDPSSPDSLHYLSPTGVNEYLMALWSVGSVVQDYDSDKLFPAFGFGAQVPPDWQVSHEFALNFNPSNPYCAGIQGIVDAYRQALPQVRLYGPTNFAPIINHVARFAAQAAHQGTASQYFMLLLLTDGAVTDVEATREAVVRASNLPMSVIIVGVGGADFEAMEQLDADGGPLHTRSGQAAARDIVQFVPYRRFQNAPREALAQTVLAEVPTQLVSYFRAQGWAPLKPLPPSAKDPAQAPQA
uniprot
proteins
function
FUNCTION: Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885). Involved in the TNF receptor signaling pathway in a calcium-dependent manner (PubMed:14674885). Exhibits calcium-dependent phospholipid binding properties (PubMed:19539605, PubMed:9430674). Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner (PubMed:23263657, PubMed:25450385). May recruit target proteins to the cell membrane in a calcium-dependent manner (PubMed:12522145). May function in membrane trafficking (PubMed:9430674). Involved in TNF-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit (PubMed:18212740). Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740). {ECO:0000269|PubMed:12522145, ECO:0000269|PubMed:14674885, ECO:0000269|PubMed:18212740, ECO:0000269|PubMed:19539605, ECO:0000269|PubMed:23263657, ECO:0000269|PubMed:25450385, ECO:0000269|PubMed:9430674}.
uniprot
proteins
mass_dalton
59059
uniprot
proteins
mutagenesis
MUTAGEN 21; /note="D->A: Inhibits translocation to the cell membrane in a calcium-dependent manner and does not inhibit neuronal progenitor cell differentiation; when associated with A-90."; /evidence="ECO:0000269|PubMed:25450385"; MUTAGEN 90; /note="D->A: Inhibits translocation to the cell membrane in a calcium-dependent manner and does not inhibit neuronal progenitor cell differentiation; when associated with A-21."; /evidence="ECO:0000269|PubMed:25450385"; MUTAGEN 216; /note="D->A: Inhibits translocation to the cell membrane in a calcium-dependent manner and does not inhibit neuronal progenitor cell differentiation; when associated with A-222."; /evidence="ECO:0000269|PubMed:25450385"; MUTAGEN 222; /note="D->A: Inhibits translocation to the cell membrane in a calcium-dependent manner and does not inhibit neuronal progenitor cell differentiation; when associated with A-216."; /evidence="ECO:0000269|PubMed:25450385
uniprot
proteins
protein_family
Copine family
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12522145
uniprot
proteins
pubmed
12949241
uniprot
proteins
pubmed
14674885
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18212740
uniprot
proteins
pubmed
19539605
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21087455
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23263657
uniprot
proteins
pubmed
25450385
uniprot
proteins
pubmed
9430674
uniprot
proteins
sequence_length
537
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18212740, ECO:0000269|PubMed:21087455}. Cytoplasm {ECO:0000269|PubMed:12949241, ECO:0000269|PubMed:18212740, ECO:0000269|PubMed:21087455, ECO:0000269|PubMed:25450385}. Cell membrane {ECO:0000269|PubMed:21087455, ECO:0000269|PubMed:25450385}. Note=Translocates to the cell membrane in a calcium-dependent manner (PubMed:21087455, PubMed:25450385). {ECO:0000269|PubMed:21087455, ECO:0000269|PubMed:25450385}.
uniprot
proteins