GOT1
entrez
2805
canonical
uniprot
P17174
canonical
ensembl
ENSG00000120053
resolver
ensp
ENSP00000359539
resolver
genesymbol
GOT1
resolver
hgnc
HGNC:4432
resolver
uniprot
A0A140VK69
resolver
uniprot
B2R6R7
resolver
uniprot
B7Z7E9
resolver
uniprot
Q5VW80
resolver
uniprot_entry
A0A140VK69_HUMAN
resolver
uniprot_entry
AATC_HUMAN
resolver
uniprot_sec
B2R6R7
resolver
uniprot_sec
B7Z7E9
resolver
uniprot_sec
Q5VW80
resolver
amino_acid_sequence
MAPPSVFAEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWVLPVVKKVEQKIANDNSLNHEYLPILGLAEFRSCASRLALGDDSPALKEKRVGGVQSLGGTGALRIGADFLARWYNGTNNKNTPVYVSSPTWENHNAVFSAAGFKDIRSYRYWDAEKRGLDLQGFLNDLENAPEFSIVVLHACAHNPTGIDPTPEQWKQIASVMKHRFLFPFFDSAYQGFASGNLERDAWAIRYFVSEGFEFFCAQSFSKNFGLYNERVGNLTVVGKEPESILQVLSQMEKIVRITWSNPPAQGARIVASTLSNPELFEEWTGNVKTMADRILTMRSELRARLEALKTPGTWNHITDQIGMFSFTGLNPKQVEYLVNEKHIYLLPSGRINVSGLTTKNLDYVATSIHEAVTKIQ
uniprot
proteins
ec_number
2.6.1.1
uniprot
proteins
ec_number
2.6.1.3
uniprot
proteins
function
FUNCTION: Biosynthesis of L-glutamate from L-aspartate or L-cysteine (PubMed:21900944). Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain. In addition, catalyzes (2S)-2-aminobutanoate, a by-product in the cysteine biosynthesis pathway (PubMed:27827456). {ECO:0000269|PubMed:16039064, ECO:0000269|PubMed:21900944, ECO:0000269|PubMed:27827456}.
uniprot
proteins
mass_dalton
46248
uniprot
proteins
protein_family
Class-I pyridoxal-phosphate-dependent aminotransferase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16039064
uniprot
proteins
pubmed
1974457
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21900944
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
2241899
uniprot
proteins
pubmed
22633534
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27827456
uniprot
proteins
sequence_length
413
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:1974457}.
uniprot
proteins