ENPP6
entrez
133121
canonical
uniprot
Q6UWR7
canonical
ensembl
ENSG00000164303
resolver
ensp
ENSP00000296741
resolver
enst
ENST00000296741
resolver
genesymbol
ENPP6
resolver
hgnc
HGNC:23409
resolver
uniprot
Q4W5Q1
resolver
uniprot
Q96M57
resolver
uniprot_entry
ENPP6_HUMAN
resolver
uniprot_sec
Q4W5Q1
resolver
uniprot_sec
Q96M57
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by EDTA and EGTA in vitro. {ECO:0000269|PubMed:15788404}.
uniprot
proteins
amino_acid_sequence
MAVKLGTLLLALALGLAQPASARRKLLVFLLDGFRSDYISDEALESLPGFKEIVSRGVKVDYLTPDFPSLSYPNYYTLMTGRHCEVHQMIGNYMWDPTTNKSFDIGVNKDSLMPLWWNGSEPLWVTLTKAKRKVYMYYWPGCEVEILGVRPTYCLEYKNVPTDINFANAVSDALDSFKSGRADLAAIYHERIDVEGHHYGPASPQRKDALKAVDTVLKYMTKWIQERGLQDRLNVIIFSDHGMTDIFWMDKVIELNKYISLNDLQQVKDRGPVVSLWPAPGKHSEIYNKLSTVEHMTVYEKEAIPSRFYYKKGKFVSPLTLVADEGWFITENREMLPFWMNSTGRREGWQRGWHGYDNELMDMRGIFLAFGPDFKSNFRAAPIRSVDVYNVMCNVVGITPLPNNGSWSRVMCMLKGRASTAPPVWPSHCALALILLFLLA
uniprot
proteins
ec_number
3.1.4.-
uniprot
proteins
ec_number
3.1.4.38
uniprot
proteins
function
FUNCTION: Choline-specific glycerophosphodiesterase that hydrolyzes glycerophosphocholine (GPC) and lysophosphatidylcholine (LPC) and contributes to supplying choline to the cells (PubMed:15788404). Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. In vitro, hydrolyzes only choline-containing lysophospholipids, such as sphingosylphosphorylcholine (SPC), platelet-activating factor (PAF) and lysoPAF, but not other lysophospholipids (By similarity). {ECO:0000250|UniProtKB:Q8BGN3, ECO:0000269|PubMed:15788404}.
uniprot
proteins
mass_dalton
50241
uniprot
proteins
protein_family
Nucleotide pyrophosphatase/phosphodiesterase family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15788404
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
23161088
uniprot
proteins
sequence_length
440
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15788404}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:15788404}. Note=A small amount of the protein may be found in the extracellular milieu.
uniprot
proteins