Atg12
entrez
361321
canonical
uniprot
Q2TBJ5
canonical
genesymbol
Atg12
resolver
genesymbol_syn
Apg12l
resolver
uniprot
Q5M9F9
resolver
uniprot_entry
ATG12_RAT
resolver
uniprot_sec
Q5M9F9
resolver
amino_acid_sequence
MAEDPEAVLQLPAAPAAAAGESLLELSPETAIPEPPSSVAVSPGTEEPPGDTKKKIDILLKAVGDTPIMKTKKWAVERTRTVQALIDFIRKFLRLLASEQLFIYVNQSFAPSPDQEVGTLYECFGSDGKLVLHYCKSQAWG
uniprot
proteins
function
FUNCTION: Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also negatively regulates the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Also plays a role in translation or delivery of incoming viral RNA to the translation apparatus (By similarity). As part of the ATG8 conjugation system with ATG5 and ATG16L1, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q9CQY1}.
uniprot
proteins
mass_dalton
15284
uniprot
proteins
post_translational_modification
PTM: Acetylated by EP300. {ECO:0000250}.
uniprot
proteins
protein_family
ATG12 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18521932
uniprot
proteins
pubmed
19696026
uniprot
proteins
pubmed
24187137
uniprot
proteins
sequence_length
141
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Preautophagosomal structure membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=TECPR1 recruits the ATG12-ATG5 conjugate to the autolysosomal membrane. {ECO:0000250}.
uniprot
proteins