TMEM41B
entrez
440026
canonical
uniprot
Q5BJD5
canonical
ensembl
ENSG00000166471
resolver
ensp
ENSP00000431934
resolver
ensp
ENSP00000433126
resolver
ensp
ENSP00000436480
resolver
genesymbol
TMEM41B
resolver
genesymbol_syn
KIAA0033
resolver
hgnc
HGNC:28948
resolver
uniprot
D3DQU9
resolver
uniprot
E9PP29
resolver
uniprot
Q15055
resolver
uniprot
Q4G0P0
resolver
uniprot_entry
TM41B_HUMAN
resolver
uniprot_sec
D3DQU9
resolver
uniprot_sec
E9PP29
resolver
uniprot_sec
Q15055
resolver
uniprot_sec
Q4G0P0
resolver
amino_acid_sequence
MAKGRVAERSQLGAHHTTPVGDGAAGTRGLAAPGSRDHQKEKSWVEAGSARMSLLILVSIFLSAAFVMFLVYKNFPQLSEEERVNMKVPRDMDDAKALGKVLSKYKDTFYVQVLVAYFATYIFLQTFAIPGSIFLSILSGFLYPFPLALFLVCLCSGLGASFCYMLSYLVGRPVVYKYLTEKAVKWSQQVERHREHLINYIIFLRITPFLPNWFINITSPVINVPLKVFFIGTFLGVAPPSFVAIKAGTTLYQLTTAGEAVSWNSIFILMILAVLSILPAIFQKKLKQKFE
uniprot
proteins
function
FUNCTION: Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes (PubMed:33850023, PubMed:33929485, PubMed:34015269). Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine (PubMed:33850023, PubMed:33929485, PubMed:34015269). Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly (PubMed:30093494, PubMed:30126924, PubMed:30933966, PubMed:33850023, PubMed:33929485, PubMed:34015269, PubMed:34043740). In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required (PubMed:33850023). Required for normal motor neuron development (By similarity). {ECO:0000250|UniProtKB:A1A5V7, ECO:0000269|PubMed:30093494, ECO:0000269|PubMed:30126924, ECO:0000269|PubMed:30933966, ECO:0000269|PubMed:33850023, ECO:0000269|PubMed:33929485, ECO:0000269|PubMed:34015269, ECO:0000269|PubMed:34043740}.; FUNCTION: (Microbial infection) Critical host factor required for infection by human coronaviruses SARS-CoV-2, HCoV-OC43, HCoV-NL63, and HCoV-229E, as well as all flaviviruses tested such as Zika virus and Yellow fever virus (PubMed:33338421, PubMed:33382968). Required post-entry of the virus to facilitate the ER membrane remodeling necessary to form replication organelles (PubMed:33382968). {ECO:0000269|PubMed:33338421, ECO:0000269|PubMed:33382968, ECO:0000269|PubMed:34043740}.
uniprot
proteins
mass_dalton
32513
uniprot
proteins
protein_family
TMEM41 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
30093494
uniprot
proteins
pubmed
30126924
uniprot
proteins
pubmed
30352685
uniprot
proteins
pubmed
30933966
uniprot
proteins
pubmed
33338421
uniprot
proteins
pubmed
33382968
uniprot
proteins
pubmed
33850023
uniprot
proteins
pubmed
33929485
uniprot
proteins
pubmed
34015269
uniprot
proteins
pubmed
34043740
uniprot
proteins
pubmed
7584026
uniprot
proteins
sequence_length
291
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:30093494, ECO:0000269|PubMed:30126924, ECO:0000269|PubMed:30352685, ECO:0000269|PubMed:30933966, ECO:0000269|PubMed:33338421, ECO:0000269|PubMed:34015269, ECO:0000269|PubMed:34043740}; Multi-pass membrane protein {ECO:0000255}. Endomembrane system {ECO:0000269|PubMed:34015269}. Note=Localized to specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. {ECO:0000269|PubMed:30352685}.; SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:33338421}. Note=(Microbial infection) Upon infection with infection with flaviviruses, diffuse reticular-like pattern to a large cytosolic aggregate that colocalizes with viral non-structural proteins, NS4A (ZIKV) and NS4B (YFV). {ECO:0000269|PubMed:33338421}.
uniprot
proteins
transmembrane_region
TRANSMEM 52..72; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 109..129; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 147..169; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 197..217; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 225..245; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 262..282; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins