Flii
entrez
14248
canonical
uniprot
Q9JJ28
canonical
ensembl
ENSMUSG00000002812
resolver
ensp
ENSMUSP00000002889
resolver
ensp
ENSMUSP00000270120
resolver
enst
ENSMUST00000002889
resolver
genesymbol
Flii
resolver
genesymbol_syn
Fli1
resolver
genesymbol_syn
Fliih
resolver
uniprot
Q8K095
resolver
uniprot
Q8VI44
resolver
uniprot_entry
FLII_MOUSE
resolver
uniprot_sec
Q8K095
resolver
uniprot_sec
Q8VI44
resolver
amino_acid_sequence
MEATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNHLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNGIDSIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMMALQTLHLRNTQRTQSNLPTSLEGLSNLSDVDLSCNDLTRVPECLYTLPSLRRLNLSSNQIAELSLCIDQWVHLETLNLSRNQLTSLPSAICKLTKLKKLYLNSNKLDFDGLPSGIGKLTSLEEFMAANNNLELIPESLCRCPKLKKLVLNKNRLVTLPEAIHFLTEIQVLDVRENPSLVMPPKPADRTAEWYNIDFSLQNQLRLAGASPATVAAAAAVGSGSKDPLARKMRLRRRKDSAQDVQAKQVLKGMSDVAQEKNKNQEESIDARAPGGKVRRWDQGLEKPRLDYSEFFTEDVGQLPGLTIWQIENFVPVLVEEAFHGKFYEADCYIVLKTFLDDSGSLNWEIYYWIGGEATLDKKACSAIHAVNLRNYLGAECRTVREEMGDESEEFLQVFDNDISYIEGGTASGFYTVEDTHYVTRMYRVYGKKNIKLEPVPLKGSSLDPRFVFLLDQGLDIYVWRGAQATLSNTTKARLFAEKINKNERKGKAEITLLVQGQEPPGFWDVLGGEPSEIKNHVPDDFWPPQPKLYKVGLGLGYLELPQINYKLSVEHKKRPKVELMPGMRLLQSLLDTRCVYILDCWSDVFIWLGRKSPRLVRAAALKLGQELCGMLHRPRHTVVSRSLEGTEAQVFKAKFKNWDDVLTVDYTRNAEAVLQGQGLSGKVKRDTEKTDQMKADLTALFLPRQPPMPLAEAEQLMEEWNEDLDGMEGFVLEGRKFTRLPEEEFGHFYTQDCYVFLCRYWVPVEYEEEEKTEDKEGKASAEAREGEEAAAEAEEKQPEEDFQCIVYFWQGREASNMGWLTFTFSLQKKFESLFPGKLEVVRMTQQQENPKFLSHFKRKFIIHRGKRKVTQGTLQPTLYQIRTNGSALCTRCIQINTDSSLLNSEFCFILKVPFESEDNQGIVYAWVGRASDPDEAKLAEDILNTMFDASYSKQVINEGEEPENFFWVGIGAQKPYDDDAEYMKHTRLFRCSNEKGYFAVTEKCSDFCQDDLADDDIMLLDNGQEVYMWVGTQTSQVEIKLSLKACQVYIQHTRSKEHERPRRLRLVRKGNEQRAFTRCFHAWSTFRQAPA
uniprot
proteins
function
FUNCTION: Is a regulator of actin polymerization, required for proper myofibril organization and regulation of the length of sarcomeric thin filaments (PubMed:22581781, PubMed:37126682). It also plays a role in the assembly of cardiomyocyte cell adhesion complexes (By similarity). Regulates cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation (PubMed:11971982, PubMed:21430700, PubMed:22581781). May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1. Involved in estrogen hormone signaling (By similarity). {ECO:0000250|UniProtKB:Q13045, ECO:0000269|PubMed:11171324, ECO:0000269|PubMed:11971982, ECO:0000269|PubMed:21430700, ECO:0000269|PubMed:22581781, ECO:0000269|PubMed:37126682}.
uniprot
proteins
mass_dalton
144803
uniprot
proteins
mutagenesis
MUTAGEN 1245; /note="R->H: Antagonizes actin polymerization in vitro. Homozygous mice have cardiac hypertrophy and reduced cardiac function. Sarcomeric thin filaments in the heart are shortened."; /evidence="ECO:0000269|PubMed:37126682
uniprot
proteins
pubmed
10902907
uniprot
proteins
pubmed
10947868
uniprot
proteins
pubmed
11171324
uniprot
proteins
pubmed
11971982
uniprot
proteins
pubmed
14966289
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21430700
uniprot
proteins
pubmed
22581781
uniprot
proteins
pubmed
23525008
uniprot
proteins
pubmed
37126682
uniprot
proteins
sequence_length
1271
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11171324}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11171324}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:11171324}. Cell junction, focal adhesion {ECO:0000269|PubMed:22581781}. Cell projection, podosome {ECO:0000269|PubMed:23525008}. Note=Colocalizes to actin-rich structures in blastocysts and, together with HRAS, RHOA and CDC42, in migrating fibroblasts. Localized to the core of macrophage podosomes (PubMed:23525008). {ECO:0000269|PubMed:11171324, ECO:0000269|PubMed:23525008}.
uniprot
proteins