Msr1
entrez
20288
canonical
uniprot
P30204
canonical
ensembl
ENSMUSG00000025044
resolver
ensp
ENSMUSP00000026021
resolver
ensp
ENSMUSP00000132535
resolver
genesymbol
Msr1
resolver
genesymbol_syn
Scvr
resolver
uniprot
E9QNQ5
resolver
uniprot
Q8CED7
resolver
uniprot
Q923G0
resolver
uniprot
Q9QZ56
resolver
uniprot_entry
MSRE_MOUSE
resolver
uniprot_entry
Q8CED7_MOUSE
resolver
uniprot_sec
E9QNQ5
resolver
uniprot_sec
Q923G0
resolver
uniprot_sec
Q9QZ56
resolver
amino_acid_sequence
MTKEMTENQRLCPHEQEDADCSSESVKFDARSMTASLPHSTKNGPSLQEKLKSFKAALIALYLLVFAVLIPVVGIVTAQLLNWEMKNCLVCSLNTSDTSQGPMEKENTSKVEMRFTIIMEHMKDMEERIESISNSKADLIDTERFQNFSMATDQRLNDILLQLNSLISSVQEHGNSLDAISKSLQSLNMTLLDVQLHTETLNVRVRESTAKQQEDISKLEERVYKVSAEVQSVKEEQAHVEQEVKQEVRVLNNITNDLRLKDWEHSQTLKNITFIQGPPGPQGEKGDRGLTGQTGPPGAPGIRGIPGVKGDRGQIGFPGGRGNPGAPGKPGRSGSPGPKGQKGEKGSVGGSTPLKTVRLVGGSGAHEGRVEIFHQGQWGTICDDRWDIRAGQVVCRSLGYQEVLAVHKRAHFGQGTGPIWLNEVMCFGRESSIENCKINQWGVLSCSHSEDAGVTCTS
uniprot
proteins
function
FUNCTION: Membrane receptor that mediates the binding, endocytosis and phagocytosis of a broad range of ligands. Recognizes and internalizes modified forms of low-density lipoproteins including acetylated LDL (AcLDL) and oxidized LDL (OxLDL), thereby promoting cholesterol uptake and contributing to foam cell formation during atherogenesis. Binds various pathogen-associated and damage-associated molecules, including bacterial cell wall components, apoptotic cell debris and polyanionic ligands, supporting macrophage clearance activity in innate immune defense (PubMed:9348300, PubMed:10722588). Upon stimulation by CpG DNA, mediates activation of LYN, which phosphorylates SYK that is subsequently recruited to endosomal TLR9 to promote downstream TLR9 signaling (PubMed:9348300, PubMed:10722588). {ECO:0000250|UniProtKB:P21757, ECO:0000269|PubMed:10722588, ECO:0000269|PubMed:9348300}.
uniprot
proteins
mass_dalton
50170
uniprot
proteins
pubmed
10722588
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
1978939
uniprot
proteins
pubmed
7666008
uniprot
proteins
pubmed
8380589
uniprot
proteins
pubmed
8394868
uniprot
proteins
pubmed
9348300
uniprot
proteins
sequence_length
458
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 56..78; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins