FAM54B
entrez
56181
canonical
uniprot
Q9H019
canonical
ensembl
ENSG00000117640
resolver
ensp
ENSP00000363418
resolver
ensp
ENSP00000363419
resolver
ensp
ENSP00000363421
resolver
ensp
ENSP00000435461
resolver
genesymbol
FAM54B
resolver
genesymbol
MTFR1L
resolver
genesymbol_syn
FAM54B
resolver
hgnc
HGNC:28836
resolver
uniprot
A0A0S2Z5H6
resolver
uniprot
A6NCB4
resolver
uniprot
B7WNV5
resolver
uniprot
D3DPJ4
resolver
uniprot
Q63HP1
resolver
uniprot
Q7Z2S7
resolver
uniprot
Q9NUI7
resolver
uniprot_entry
A0A0S2Z5H6_HUMAN
resolver
uniprot_entry
MFR1L_HUMAN
resolver
uniprot_sec
A6NCB4
resolver
uniprot_sec
B7WNV5
resolver
uniprot_sec
D3DPJ4
resolver
uniprot_sec
Q63HP1
resolver
uniprot_sec
Q7Z2S7
resolver
uniprot_sec
Q9NUI7
resolver
amino_acid_sequence
MSGMEATVTIPIWQNKPHGAARSVVRRIGTNLPLKPCARASFETLPNISDLCLRDVPPVPTLADIAWIAADEEETYARVRSDTRPLRHTWKPSPLIVMQRNASVPNLRGSEERLLALKKPALPALSRTTELQDELSHLRSQIAKIVAADAASASLTPDFLSPGSSNVSSPLPCFGSSFHSTTSFVISDITEETEVEVPELPSVPLLCSASPECCKPEHKAACSSSEEDDCVSLSKASSFADMMGILKDFHRMKQSQDLNRSLLKEEDPAVLISEVLRRKFALKEEDISRKGN
uniprot
proteins
function
FUNCTION: Mitochondrial protein required for adaptation of mitochondrial dynamics to metabolic changes. Regulates mitochondrial morphology at steady state and mediates AMPK-dependent stress-induced mitochondrial fragmentation via the control of OPA1 levels. {ECO:0000269|PubMed:36367943}.
uniprot
proteins
mass_dalton
31957
uniprot
proteins
mutagenesis
MUTAGEN 103; /note="S->A: Loss of phosphorylation by AMPK. No effect on mitochondrial morphology; when associated with A-238."; /evidence="ECO:0000269|PubMed:36367943"; MUTAGEN 103; /note="S->D: Leads to fragmentation of mitochondrial network; when associated with D-238."; /evidence="ECO:0000269|PubMed:36367943"; MUTAGEN 238; /note="S->A: Loss of phosphorylation by AMPK. No effect on mitochondrial morphology; when associated with A-103."; /evidence="ECO:0000269|PubMed:36367943"; MUTAGEN 238; /note="S->D: Leads to fragmentation of mitochondrial network; when associated with D-103."; /evidence="ECO:0000269|PubMed:36367943
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by AMPK. Upon stress, phosphorylation at Ser-103 and Ser-238 by AMPK is sufficient to induce mitochondrial fragmentation. {ECO:0000269|PubMed:36367943}.
uniprot
proteins
protein_family
MTFR1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15221005
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
36367943
uniprot
proteins
sequence_length
292
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:36367943}; Peripheral membrane protein {ECO:0000269|PubMed:36367943}; Cytoplasmic side {ECO:0000269|PubMed:36367943}.
uniprot
proteins