Atp6v0a2
entrez
21871
canonical
uniprot
P15920
canonical
ensembl
ENSMUSG00000038023
resolver
ensp
ENSMUSP00000039737
resolver
genesymbol
Atp6v0a2
resolver
genesymbol_syn
Atp6n1b
resolver
genesymbol_syn
Tj6
resolver
uniprot
A4FU82
resolver
uniprot
Q3U2X3
resolver
uniprot
Q8VHU0
resolver
uniprot
Q9JHJ2
resolver
uniprot_entry
VPP2_MOUSE
resolver
uniprot_sec
A4FU82
resolver
uniprot_sec
Q3U2X3
resolver
uniprot_sec
Q8VHU0
resolver
uniprot_sec
Q9JHJ2
resolver
amino_acid_sequence
MGSLFRSESMCLAQLFLQSGTAYECLSALGEKGLVQFRDLNQNVSSFQRKFVGEVKRCEELERILVYLVQEITRADIPLPEGEASPPAPPLKHVLEMQEQLQKLEVELREVTKNKEKLRKNLLELVEYTHMLRVTKTFLKRNVEFEPTYEEFPALENDSLLDYSCMQRLGAKLGFVSGLIQQGRVEAFERMLWRACKGYTIVTYAELDECLEDPETGEVIKWYVFLISFWGEQIGHKVKKICDCYHCHIYPYPNTAEERREIQEGLNTRIQDLYTVLHKTEDYLRQVLCKAAESVCSRVVQVRKMKAIYHMLNMCSFDVTNKCLIAEVWCPEVDLPGLRRALEEGSRESGATIPSFMNTIPTKETPPTLIRTNKFTEGFQNIVDAYGVGSYREVNPALFTIITFPFLFAVMFGDFGHGFVMFLFALLLVLNENHPRLSQSQEILRMFFDGRYILLLMGLFSVYTGLIYNDCFSKSVNLFGSGWNVSAMYSSSHSPEEQRKMVLWNDSTIRHSRTLQLDPNIPGVFRGPYPFGIDPIWNLATNRLTFLNSFKMKMSVILGIFHMTFGVVLGIFNHLHFRKKFNVYLVSVPEILFMLCIFGYLIFMIIYKWLAYSAETSREAPSILIEFINMFLFPTSKTHGLYPGQAHVQRVLVALTVLAVPVLFLGKPLFLLWLHNGRNCFGMSRSGYTLVRKDSEEEVSLLGNQDIEEGNSRMEEGCREVTCEEFNFGEILMTQAIHSIEYCLGCISNTASYLRLWALSLAHAQLSDVLWAMLMRVGLRVDTTYGVLLLLPVMAFFAVLTIFILLVMEGLSAFLHAIRLHWVEFQNKFYVGAGTKFVPFSFSLLSSKFSNDDSIA
uniprot
proteins
function
FUNCTION: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Essential component of the endosomal pH-sensing machinery (PubMed:16415858). May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). {ECO:0000250|UniProtKB:Q29466, ECO:0000250|UniProtKB:Q93050, ECO:0000250|UniProtKB:Q9Y487, ECO:0000269|PubMed:16415858}.
uniprot
proteins
mass_dalton
98145
uniprot
proteins
protein_family
V-ATPase 116 kDa subunit family
uniprot
proteins
pubmed
10702241
uniprot
proteins
pubmed
10722719
uniprot
proteins
pubmed
11375395
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16415858
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2247090
uniprot
proteins
sequence_length
856
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16415858}; Multi-pass membrane protein {ECO:0000269|PubMed:16415858}. Endosome membrane {ECO:0000269|PubMed:16415858}. Note=In kidney proximal tubules, detected in subapical early endosomes.
uniprot
proteins
transmembrane_region
TRANSMEM 394..412; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 415..431; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 446..475; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 550..569; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 588..608; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 652..671; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 740..764; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 786..824; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins