Dusp18
entrez
75219
canonical
uniprot
Q8VE01
canonical
ensembl
ENSMUSG00000047205
resolver
ensp
ENSMUSP00000057346
resolver
ensp
ENSMUSP00000105624
resolver
ensp
ENSMUSP00000315628
resolver
enst
ENSMUST00000055931
resolver
enst
ENSMUST00000109996
resolver
genesymbol
Dusp18
resolver
uniprot
Q8BWD7
resolver
uniprot_entry
DUS18_MOUSE
resolver
uniprot_entry
Q8BWD7_MOUSE
resolver
amino_acid_sequence
MTSPWSAFPVQIPQPSIRGLSQITKSLFISNGVAANNKLLLSSNQITTVINVSVEVANTFYEDIQYVQVPVVDAPVARLSNFFDSVADRIHSVEMQKGRTLLHCAAGVSRSAALCLAYLMKYHAMSLVDAHTWTKSCRPIIRPNSGFWEQLIHYELQLFGKNTMQMMDSPMGRIPDIYEKETRLMIPL
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Can dephosphorylate single and diphosphorylated synthetic MAPK peptides, with preference for the phosphotyrosine and diphosphorylated forms over phosphothreonine. In vitro, dephosphorylates p-nitrophenyl phosphate (pNPP). In bone tissue, upon activation of the G(q)-dependent KISS1/KISS1R signaling pathway, DUSP18 is recruited to the KISS1R C-terminus, where it dephosphorylates SRC resulting in down-regulation of osteoclast differentiation and activity, and consequently suppression of bone resorption (PubMed:38346942). {ECO:0000250|UniProtKB:Q8NEJ0, ECO:0000269|PubMed:38346942}.
uniprot
proteins
mass_dalton
21119
uniprot
proteins
protein_family
Non-receptor class dual specificity subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18385140
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
38346942
uniprot
proteins
pubmed
39702286
uniprot
proteins
sequence_length
188
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18385140}. Nucleus {ECO:0000250|UniProtKB:Q8NEJ0}. Mitochondrion inner membrane {ECO:0000269|PubMed:18385140}; Peripheral membrane protein {ECO:0000269|PubMed:18385140}; Intermembrane side {ECO:0000269|PubMed:18385140}. Note=Translocates to cytoplasm in response to apoptotic stimuli such as staurosporine treatment. {ECO:0000269|PubMed:18385140}.
uniprot
proteins