Ift25
entrez
72938
canonical
uniprot
Q9D6H2
canonical
ensembl
ENSMUSG00000063172
resolver
ensp
ENSMUSP00000048810
resolver
ensp
ENSMUSP00000102360
resolver
ensp
ENSMUSP00000118617
resolver
enst
ENSMUST00000046558
resolver
enst
ENSMUST00000106749
resolver
enst
ENSMUST00000152717
resolver
genesymbol
Ift25
resolver
genesymbol_syn
Hspb11
resolver
uniprot
Q3TZR2
resolver
uniprot
Q8VDG4
resolver
uniprot_entry
IFT25_MOUSE
resolver
uniprot_entry
Q8VDG4_MOUSE
resolver
uniprot_sec
Q3TZR2
resolver
amino_acid_sequence
MRKVDLCSVTEGTEVILATSSDEKHPPENIIDGNPETFWTTTGMFPQEFIICFHKHVKIEKLVIQSYLVRTLRIEKTTSKEPLDFEQWVEKDLVHTEGQLQNEEIVARDGYATFLRFIIVSAFDHFASVHSISAEGLTVSSLP
uniprot
proteins
function
FUNCTION: Component of the IFT complex B required for sonic hedgehog/SHH signaling. May mediate transport of SHH components: required for the export of SMO and PTCH1 receptors out of the cilium and the accumulation of GLI2 at the ciliary tip in response to activation of the SHH pathway, suggesting it is involved in the dynamic transport of SHH signaling molecules within the cilium. Not required for ciliary assembly (PubMed:22595669). Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation (PubMed:28430876). Plays a role in the early development of the kidney (PubMed:29626631). May be involved in the regulation of ureteric bud initiation (PubMed:29626631). {ECO:0000269|PubMed:22595669, ECO:0000269|PubMed:28430876, ECO:0000269|PubMed:29626631}.
uniprot
proteins
mass_dalton
16281
uniprot
proteins
protein_family
IFT25 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19253336
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22595669
uniprot
proteins
pubmed
28430876
uniprot
proteins
pubmed
28964737
uniprot
proteins
pubmed
29626631
uniprot
proteins
sequence_length
143
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:19253336}.
uniprot
proteins