Pgp
entrez
287115
canonical
uniprot
D3ZDK7
canonical
genesymbol
Pgp
resolver
uniprot_entry
PGP_RAT
resolver
amino_acid_sequence
MAEAEAGGDEVRCVRLSAERAKLLLAEVDTLLFDCDGVLWRGETAVPGAPETLRALRARGKRLGFITNNSSKTRTAYAEKLRRLGFGGPMGPEAGLEVFGTAYCSALYLRQRLAGVPDPKAYVLGSPALAAELEAVGVTSVGVGPDVLHGDGPSDWLAVPLEPDVRAVVVGFDPHFSYMKLTKAVRYLQQPDCLLVGTNMDNRLPLENGRFIAGTGCLVRAVEMAAQRQADIIGKPSRFIFDCVSQEYGINPERTVMVGDRLDTDILLGSTCSLKTILTLTGVSSLEDVKSNQESDCMFKKKMVPDFYVDSIADLLPALQG
uniprot
proteins
ec_number
3.1.3.18
uniprot
proteins
ec_number
3.1.3.21
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Phosphatase with activity against multiple substrates (By similarity). Acts as a metabolite repair enzyme which eliminates toxic glycolytic side products (By similarity). Dephosphorylates 2-phosphoglycolate which is generated during the repair of oxidative DNA lesions (By similarity). This controls triosephosphate isomerase activity, glycerolipid partitioning and cell proliferation in the embryo and is required for embryonic development (By similarity). Dephosphorylates 4-phosphoerythronate, a side product which is produced by GAPDH and which inhibits 6-phosphogluconate dehydrogenase (By similarity). Dephosphorylation of 4-phosphoerythronate prevents the accumulation of high 4-phosphoerythronate levels which would otherwise inhibit the pentose phosphate pathway (By similarity). Dephosphorylates 2-phospho-L-lactate which is a product of a pyruvate kinase side reaction (By similarity). This prevents the inhibition of fructose-2,6-bisphosphate production and allows glycolysis to occur (By similarity). Has glycerol-3-phosphate phosphatase activity, hydrolyzing glycerol-3-phosphate into glycerol and thereby regulating the cellular levels of glycerol-3-phosphate, a metabolic intermediate of glucose, lipid and energy metabolism (By similarity). Has been shown to have tyrosine-protein phosphatase activity although the physiological relevance is unclear (By similarity). In vitro, has phosphatase activity toward ADP, ATP, GDP and GTP (By similarity). {ECO:0000250|UniProtKB:A6NDG6, ECO:0000250|UniProtKB:Q8CHP8}.
uniprot
proteins
mass_dalton
34601
uniprot
proteins
protein_family
CbbY/CbbZ/Gph/YieH family
uniprot
proteins
protein_family
HAD-like hydrolase superfamily
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
26755581
uniprot
proteins
sequence_length
321
uniprot
proteins