Npr3
entrez
25339
canonical
uniprot
P41740
canonical
ensembl
ENSRNOG00000019184
resolver
ensp
ENSRNOP00000025966
resolver
enst
ENSRNOT00000025966
resolver
genesymbol
Npr3
resolver
genesymbol_syn
Npr-c
resolver
uniprot
A0A8L2QFC4
resolver
uniprot
Q64156
resolver
uniprot_entry
A0A8L2QFC4_RAT
resolver
uniprot_entry
ANPRC_RAT
resolver
uniprot_sec
Q64156
resolver
amino_acid_sequence
MRSLLLFTFSACVLLARALLAGGASSGGGDTGPGNRRREREALAAQKIEVLVLLPRDDSYLFSLARVRPAIEYALRSVEGNGTGRKLLPPGTRFQVAYEDSDCGNRALFSLVDRVAAARGAKPDLILGPVCEYAAAPVARLASHWDLPMLSAGALAAGFQHKDTEYSHLTRVAPAYAKMGEMMLALFRHHHWSRAALLYSDDKLERNCYFTLEGVHEVFQEEGLHTSAYNFDETKDLDLDDIVRYIQGSERVVIMCASGDTIRRIMLAVHRHGMTSGDYAFFNIELFNSSSYGDGSWKRGDKHDFEAKQAYSSLQTVTLLRTAKPEFEKFSMEVKSSVEKQGLNEEDYVNMFVEGFHDAILLYVLALHEVLRAGYSKKDGGKIIQQTWNRTFEGIAGQVSIDANGDRYGDFSVVAMTDTEAGTQEVIGDYFGKEGRFKMRSNVKYPWGSLKLRIDETRIVEHTNSSPCKSCGLEESAVTGIVVGALLGAGLLMAFYFFRKKYRITIERRNHQEESNIGKHRELREDSIRSHFSVA
uniprot
proteins
function
FUNCTION: Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. Acts as a regulator of osteoblast differentiation and bone growth by binding to its ligand osteocrin, thereby preventing binding between NPR3/NPR-C and natriuretic peptides, leading to increase cGMP production. {ECO:0000250|UniProtKB:P70180}.
uniprot
proteins
mass_dalton
59728
uniprot
proteins
protein_family
ANF receptor family
uniprot
proteins
pubmed
7554122
uniprot
proteins
pubmed
7911802
uniprot
proteins
sequence_length
535
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P17342}; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 478..498; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins