RAP1A
entrez
5906
canonical
uniprot
P62834
canonical
ensembl
ENSG00000116473
resolver
ensp
ENSP00000348786
resolver
ensp
ENSP00000358723
resolver
ensp
ENSP00000509234
resolver
ensp
ENSP00000525050
resolver
ensp
ENSP00000525051
resolver
ensp
ENSP00000525053
resolver
ensp
ENSP00000525055
resolver
ensp
ENSP00000525056
resolver
ensp
ENSP00000525057
resolver
ensp
ENSP00000525059
resolver
ensp
ENSP00000525060
resolver
ensp
ENSP00000525062
resolver
ensp
ENSP00000525063
resolver
ensp
ENSP00000525064
resolver
ensp
ENSP00000525065
resolver
ensp
ENSP00000525066
resolver
ensp
ENSP00000525068
resolver
ensp
ENSP00000525069
resolver
ensp
ENSP00000525070
resolver
ensp
ENSP00000525071
resolver
ensp
ENSP00000525072
resolver
ensp
ENSP00000525073
resolver
ensp
ENSP00000525074
resolver
ensp
ENSP00000525075
resolver
ensp
ENSP00000617754
resolver
ensp
ENSP00000617755
resolver
ensp
ENSP00000617756
resolver
ensp
ENSP00000617757
resolver
ensp
ENSP00000617759
resolver
ensp
ENSP00000617760
resolver
ensp
ENSP00000617761
resolver
enst
ENST00000356415
resolver
enst
ENST00000369709
resolver
enst
ENST00000687939
resolver
enst
ENST00000854991
resolver
enst
ENST00000854992
resolver
enst
ENST00000854994
resolver
enst
ENST00000854996
resolver
enst
ENST00000854997
resolver
enst
ENST00000854998
resolver
enst
ENST00000855000
resolver
enst
ENST00000855001
resolver
enst
ENST00000855003
resolver
enst
ENST00000855004
resolver
enst
ENST00000855005
resolver
enst
ENST00000855006
resolver
enst
ENST00000855007
resolver
enst
ENST00000855009
resolver
enst
ENST00000855010
resolver
enst
ENST00000855011
resolver
enst
ENST00000855012
resolver
enst
ENST00000855013
resolver
enst
ENST00000855014
resolver
enst
ENST00000855015
resolver
enst
ENST00000855016
resolver
enst
ENST00000947695
resolver
enst
ENST00000947696
resolver
enst
ENST00000947697
resolver
enst
ENST00000947698
resolver
enst
ENST00000947700
resolver
enst
ENST00000947701
resolver
enst
ENST00000947702
resolver
genesymbol
RAP1A
resolver
genesymbol_syn
KREV1
resolver
hgnc
HGNC:9855
resolver
uniprot
A8KAH9
resolver
uniprot
P10113
resolver
uniprot_entry
A8KAH9_HUMAN
resolver
uniprot_entry
RAP1A_HUMAN
resolver
uniprot_sec
P10113
resolver
activity_regulation
ACTIVITY REGULATION: Activated by guanine nucleotide-exchange factors (GEF) EPAC and EPAC2 in a cAMP-dependent manner, and GFR.
uniprot
proteins
amino_acid_sequence
MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDLEDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKSCLLL
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (PubMed:17916086). Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. Facilitates the progressive accumulation of CDH1 at mature desmosome junctions via cAMP-dependent signaling and its interaction with PKP3 (PubMed:25208567). May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. {ECO:0000269|PubMed:17916086, ECO:0000269|PubMed:21840392, ECO:0000269|PubMed:25208567}.
uniprot
proteins
mass_dalton
20987
uniprot
proteins
protein_family
Ras family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10608844
uniprot
proteins
pubmed
11022048
uniprot
proteins
pubmed
11359771
uniprot
proteins
pubmed
12444546
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17509819
uniprot
proteins
pubmed
17704304
uniprot
proteins
pubmed
17916086
uniprot
proteins
pubmed
1899909
uniprot
proteins
pubmed
20709748
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21840392
uniprot
proteins
pubmed
2507536
uniprot
proteins
pubmed
25208567
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
3045729
uniprot
proteins
pubmed
3141412
uniprot
proteins
pubmed
3144274
uniprot
proteins
pubmed
7791872
uniprot
proteins
pubmed
8756332
uniprot
proteins
sequence_length
184
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11359771}; Lipid-anchor {ECO:0000269|PubMed:11359771}. Cytoplasm {ECO:0000269|PubMed:11359771}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11359771}. Cell junction {ECO:0000250}. Early endosome {ECO:0000250}. Note=Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. Localized with RAPGEF2 at cell-cell junctions (By similarity). Colocalized with RAPGEF2 in the perinuclear region. {ECO:0000250}.
uniprot
proteins