SLC22A9
entrez
114571
canonical
uniprot
Q8IVM8
canonical
ensembl
ENSG00000149742
resolver
ensp
ENSP00000279178
resolver
ensp
ENSP00000778169
resolver
genesymbol
SLC22A9
resolver
genesymbol_syn
OAT7
resolver
genesymbol_syn
UST3
resolver
genesymbol_syn
hOAT4
resolver
hgnc
HGNC:16261
resolver
uniprot
A0AVB7
resolver
uniprot
A4PB24
resolver
uniprot
Q8TCC8
resolver
uniprot
Q8TEC0
resolver
uniprot
Q8WYN7
resolver
uniprot_entry
S22A9_HUMAN
resolver
uniprot_sec
A0AVB7
resolver
uniprot_sec
A4PB24
resolver
uniprot_sec
Q8TCC8
resolver
uniprot_sec
Q8TEC0
resolver
uniprot_sec
Q8WYN7
resolver
amino_acid_sequence
MAFQDLLGHAGDLWRFQILQTVFLSIFAVATYLHFMLENFTAFIPGHRCWVHILDNDTVSDNDTGALSQDALLRISIPLDSNMRPEKCRRFVHPQWQLLHLNGTFPNTSDADMEPCVDGWVYDRISFSSTIVTEWDLVCDSQSLTSVAKFVFMAGMMVGGILGGHLSDRFGRRFVLRWCYLQVAIVGTCAALAPTFLIYCSLRFLSGIAAMSLITNTIMLIAEWATHRFQAMGITLGMCPSGIAFMTLAGLAFAIRDWHILQLVVSVPYFVIFLTSSWLLESARWLIINNKPEEGLKELRKAAHRSGMKNARDTLTLEILKSTMKKELEAAQKKKPSLCEMLHMPNICKRISLLSFTRFANFMAYFGLNLHVQHLGNNVFLLQTLFGAVILLANCVAPWALKYMNRRASQMLLMFLLAICLLAIIFVPQEMQTLREVLATLGLGASALANTLAFAHGNEVIPTIIRARAMGINATFANIAGALAPLMMILSVYSPPLPWIIYGVFPFISGFAFLLLPETRNKPLFDTIQDEKNERKDPREPKQEDPRVEVTQF
uniprot
proteins
function
FUNCTION: Sodium-independent organic anion transporter, exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones such as estrone 3-sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS) (PubMed:17393504, PubMed:26239079, PubMed:28945155). Can transport the statin pravastatin and may contribute to its disposition into the hepatocytes when the function of OATPs is compromised (PubMed:26239079). It is specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate (propanoate), butyrate (butanoate) and valerate (pentanoate) (PubMed:17393504). May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs, in particular butanoate, at the sinusoidal membrane of hepatocytes (PubMed:17393504). {ECO:0000269|PubMed:17393504, ECO:0000269|PubMed:26239079, ECO:0000269|PubMed:28945155}.
uniprot
proteins
mass_dalton
62169
uniprot
proteins
protein_family
Major facilitator (TC 2.A.1) superfamily
uniprot
proteins
protein_family
Organic cation transporter (TC 2.A.1.19) family
uniprot
proteins
pubmed
11327718
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17393504
uniprot
proteins
pubmed
26239079
uniprot
proteins
pubmed
28945155
uniprot
proteins
sequence_length
553
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:17393504}; Multi-pass membrane protein {ECO:0000269|PubMed:17393504}. Note=Enriched at the sinusoidal part of the plasma membrane.
uniprot
proteins
transmembrane_region
TRANSMEM 16..36; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 144..164; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 178..198; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 204..224; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 234..254; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 260..280; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 351..369; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 379..399; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 408..428; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 437..457; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 470..490; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 496..516; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins