HMGN1
entrez
3150
canonical
uniprot
P05114
canonical
ensembl
ENSG00000205581
resolver
ensp
ENSP00000370125
resolver
ensp
ENSP00000580731
resolver
ensp
ENSP00000580732
resolver
ensp
ENSP00000580733
resolver
ensp
ENSP00000580734
resolver
ensp
ENSP00000616358
resolver
ensp
ENSP00000616359
resolver
enst
ENST00000380749
resolver
enst
ENST00000910672
resolver
enst
ENST00000910673
resolver
enst
ENST00000910674
resolver
enst
ENST00000910675
resolver
enst
ENST00000946299
resolver
enst
ENST00000946300
resolver
genesymbol
HMGN1
resolver
genesymbol_syn
HMG14
resolver
hgnc
HGNC:4984
resolver
uniprot
Q3KQR8
resolver
uniprot
Q6NSG7
resolver
uniprot_entry
HMGN1_HUMAN
resolver
uniprot_entry
Q6NSG7_HUMAN
resolver
uniprot_sec
Q3KQR8
resolver
amino_acid_sequence
MPKRKVSSAEGAAKEEPKRRSARLSAKPPAKVEAKPKKAAAKDKSSDKKVQTKGKRGAKGKQAEVANQETKEDLPAENGETKTEESPASDEAGEKEAKSD
uniprot
proteins
function
FUNCTION: Binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. May be involved in the process which maintains transcribable genes in a unique chromatin conformation. Inhibits the phosphorylation of nucleosomal histones H3 and H2A by RPS6KA5/MSK1 and RPS6KA3/RSK2 (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
10659
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Ser-21 and Ser-25 weakens binding to nucleosomes and increases the rate of H3 phosphorylation (By similarity). Phosphorylation favors cytoplasmic localization. {ECO:0000250, ECO:0000269|PubMed:10739259}.
uniprot
proteins
protein_family
HMGN family
uniprot
proteins
pubmed
10739259
uniprot
proteins
pubmed
10830953
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18993075
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2563381
uniprot
proteins
pubmed
28190768
uniprot
proteins
pubmed
33468658
uniprot
proteins
pubmed
3782107
uniprot
proteins
sequence_length
100
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Cytoplasmic enrichment upon phosphorylation. The RNA edited version localizes to the nucleus.
uniprot
proteins