Mecr
entrez
26922
canonical
uniprot
Q9DCS3
canonical
ensembl
ENSMUSG00000028910
resolver
ensp
ENSMUSP00000030742
resolver
enst
ENSMUST00000030742
resolver
genesymbol
Mecr
resolver
genesymbol_syn
Nrbf1
resolver
uniprot
Q99L39
resolver
uniprot_entry
MECR_MOUSE
resolver
uniprot_sec
Q99L39
resolver
amino_acid_sequence
MLVSQRVTGARARAPQLAGLLEAWYRHGRTTSSYSALSEPSRVRALVYGNHGDPAKVVQLKNLELTAVEGSDVHVRMLAAPINPSDINMIQGNYGLLPKLPAVGGNEGVGQVIAVGSSVSALKPGDWVIPANAGLGTWRTEAVFSEEALIGIPKDIPLQSAATLGVNPCTAYRMLVDFEQLQPGDSVIQNASNSGVGQAVIQIASALRLKTINVVRDRPDIKKLTDRLKDLGADYVLTEEELRMPETKTIFKDLPLPRLALNCVGGKSSTELLRHLAPGGTMVTYGGMAKQPVTASVSLLIFKDLKLRGFWLSQWKKNHSPDEFKELILTLCNLIRQGRLTAPSCSEVPLQGYQQALEASMKPFVSSKQILTM
uniprot
proteins
ec_number
1.3.1.104
uniprot
proteins
function
FUNCTION: Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Displays a preference for medium-chain over short- and long-chain substrates (By similarity). May provide the octanoyl chain used for lipoic acid biosynthesis, regulating protein lipoylation and mitochondrial respiratory activity particularly in Purkinje cells (PubMed:30266742). Involved in iron homeostasis; affecting Fe-S cluster assembly and ceramide metabolism (By similarity). Required for proper morphology and bioenergetic functions of mitochondria (By similarity). Required for maintenance of neurons (By similarity). {ECO:0000250|UniProtKB:Q9BV79, ECO:0000250|UniProtKB:Q9V6U9, ECO:0000269|PubMed:30266742}.
uniprot
proteins
mass_dalton
40343
uniprot
proteins
protein_family
Quinone oxidoreductase subfamily
uniprot
proteins
protein_family
Zinc-containing alcohol dehydrogenase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
28369354
uniprot
proteins
pubmed
30266742
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9BV79}.
uniprot
proteins