Aqp1
entrez
11826
canonical
uniprot
Q02013
canonical
ensembl
ENSMUSG00000004655
resolver
ensp
ENSMUSP00000004774
resolver
enst
ENSMUST00000004774
resolver
genesymbol
Aqp1
resolver
uniprot
Q542P1
resolver
uniprot
Q91VY8
resolver
uniprot_entry
AQP1_MOUSE
resolver
uniprot_sec
Q542P1
resolver
uniprot_sec
Q91VY8
resolver
amino_acid_sequence
MASEIKKKLFWRAVVAEFLAMTLFVFISIGSALGFNYPLERNQTLVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISILRAVMYIIAQCVGAIVATAILSGITSSLVDNSLGRNDLAHGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVLTRNFSNHWIFWVGPFIGGALAVLIYDFILAPRSSDFTDRMKVWTSGQVEEYDLDADDINSRVEMKPK
uniprot
proteins
function
FUNCTION: Forms a water channel that facilitates the transport of water across cell membranes, playing a crucial role in water homeostasis in various tissues (PubMed:12133842). Could also be permeable to small solutes including hydrogen peroxide, glycerol and gases such as amonnia (NH3), nitric oxide (NO) and carbon dioxide (CO2). Recruited to the ankyrin-1 complex, a multiprotein complex of the erythrocyte membrane, it could be part of a CO2 metabolon, linking facilitated diffusion of CO2 across the membrane, anion exchange of Cl(-)/HCO3(-) and interconversion of dissolved CO2 and carbonic acid in the cytosol. In vitro, it shows non-selective gated cation channel activity and may be permeable to cations like K(+) and Na(+) in vivo (By similarity). {ECO:0000250|UniProtKB:P29972, ECO:0000269|PubMed:12133842}.
uniprot
proteins
mass_dalton
28793
uniprot
proteins
protein_family
MIP/aquaporin (TC 1.A.8) family
uniprot
proteins
pubmed
10839360
uniprot
proteins
pubmed
12133842
uniprot
proteins
pubmed
1508193
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31605441
uniprot
proteins
sequence_length
269
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12133842}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P29972}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..29; /note="Helical; Name=Helix 1"; /evidence="ECO:0000250|UniProtKB:P29972"; TRANSMEM 47..65; /note="Helical; Name=Helix 2"; /evidence="ECO:0000250|UniProtKB:P29972"; TRANSMEM 91..109; /note="Helical; Name=Helix 3"; /evidence="ECO:0000250|UniProtKB:P29972"; TRANSMEM 134..153; /note="Helical; Name=Helix 4"; /evidence="ECO:0000250|UniProtKB:P29972"; TRANSMEM 164..181; /note="Helical; Name=Helix 5"; /evidence="ECO:0000250|UniProtKB:P29972"; TRANSMEM 207..224; /note="Helical; Name=Helix 6"; /evidence="ECO:0000250|UniProtKB:P29972
uniprot
proteins