MAEL
entrez
84944
canonical
uniprot
Q96JY0
canonical
ensembl
ENSG00000143194
resolver
ensp
ENSP00000356844
resolver
ensp
ENSP00000356846
resolver
ensp
ENSP00000482771
resolver
ensp
ENSP00000762780
resolver
enst
ENST00000622874
resolver
genesymbol
MAEL
resolver
hgnc
HGNC:25929
resolver
uniprot
A0A087WZM9
resolver
uniprot
A0A140VJP0
resolver
uniprot
B4DY43
resolver
uniprot
E9JVC3
resolver
uniprot
E9JVC4
resolver
uniprot
Q49AP9
resolver
uniprot
Q5VZP8
resolver
uniprot
Q9UIW6
resolver
uniprot_entry
A0A087WZM9_HUMAN
resolver
uniprot_entry
A0A140VJP0_HUMAN
resolver
uniprot_entry
E9JVC4_HUMAN
resolver
uniprot_entry
MAEL_HUMAN
resolver
uniprot_sec
B4DY43
resolver
uniprot_sec
E9JVC3
resolver
uniprot_sec
Q49AP9
resolver
uniprot_sec
Q5VZP8
resolver
uniprot_sec
Q9UIW6
resolver
amino_acid_sequence
MPNRKASRNAYYFFVQEKIPELRRRGLPVARVADAIPYCSSDWALLREEEKEKYAEMAREWRAAQGKDPGPSEKQKPVFTPLRRPGMLVPKQNVSPPDMSALSLKGDQALLGGIFYFLNIFSHGELPPHCEQRFLPCEIGCVKYSLQEGIMADFHSFINPGEIPRGFRFHCQAASDSSHKIPISNFERGHNQATVLQNLYRFIHPNPGNWPPIYCKSDDRTRVNWCLKHMAKASEIRQDLQLLTVEDLVVGIYQQKFLKEPSKTWIRSLLDVAMWDYSSNTRCKWHEENDILFCALAVCKKIAYCISNSLATLFGIQLTEAHVPLQDYEASNSVTPKMVVLDAGRYQKLRVGSSGFSHFNSSNEEQRSNTPIGDYPSRAKISGQNSSVRGRGITRLLESISNSSSNIHKFSNCDTSLSPYMSQKDGYKSFSSLS
uniprot
proteins
function
FUNCTION: Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage (By similarity). {ECO:0000250|UniProtKB:Q8BVN9}.
uniprot
proteins
mass_dalton
49219
uniprot
proteins
protein_family
Maelstrom family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19693694
uniprot
proteins
sequence_length
434
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8BVN9}. Nucleus {ECO:0000250|UniProtKB:Q8BVN9}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Specifically localizes to piP-bodies, a subset of the nuage which contains secondary piRNAs (By similarity). {ECO:0000250|UniProtKB:Q8BVN9}.
uniprot
proteins