SRRM1
entrez
10250
canonical
uniprot
Q8IYB3
canonical
ensembl
ENSG00000133226
resolver
ensp
ENSP00000326261
resolver
ensp
ENSP00000516157
resolver
ensp
ENSP00000516158
resolver
ensp
ENSP00000516159
resolver
ensp
ENSP00000516160
resolver
ensp
ENSP00000544427
resolver
ensp
ENSP00000544433
resolver
ensp
ENSP00000598629
resolver
ensp
ENSP00000625659
resolver
ensp
ENSP00000755553
resolver
ensp
ENSP00000755554
resolver
enst
ENST00000705662
resolver
enst
ENST00000705663
resolver
enst
ENST00000705681
resolver
enst
ENST00000705682
resolver
genesymbol
SRRM1
resolver
genesymbol_syn
SRM160
resolver
hgnc
HGNC:16638
resolver
uniprot
A0A0S2Z4W1
resolver
uniprot
A0A0S2Z4Z6
resolver
uniprot
A0A994J4Y3
resolver
uniprot
A0A994J567
resolver
uniprot
A0A994J7H1
resolver
uniprot
A0A994J7V4
resolver
uniprot
B7Z7U0
resolver
uniprot
O60585
resolver
uniprot
Q5VVN4
resolver
uniprot_entry
A0A0S2Z4W1_HUMAN
resolver
uniprot_entry
A0A0S2Z4Z6_HUMAN
resolver
uniprot_entry
A0A994J4Y3_HUMAN
resolver
uniprot_entry
A0A994J567_HUMAN
resolver
uniprot_entry
A0A994J7H1_HUMAN
resolver
uniprot_entry
A0A994J7V4_HUMAN
resolver
uniprot_entry
B7Z7U0_HUMAN
resolver
uniprot_entry
SRRM1_HUMAN
resolver
uniprot_sec
O60585
resolver
uniprot_sec
Q5VVN4
resolver
amino_acid_sequence
MDAGFFRGTSAEQDNRFSNKQKKLLKQLKFAECLEKKVDMSKVNLEVIKPWITKRVTEILGFEDDVVIEFIFNQLEVKNPDSKMMQINLTGFLNGKNAREFMGELWPLLLSAQENIAGIPSAFLELKKEEIKQRQIEQEKLASMKKQDEDKDKRDKEEKESSREKRERSRSPRRRKSRSPSPRRRSSPVRRERKRSHSRSPRHRTKSRSPSPAPEKKEKTPELPEPSVKVKEPSVQEATSTSDILKVPKPEPIPEPKEPSPEKNSKKEKEKEKTRPRSRSRSKSRSRTRSRSPSHTRPRRRHRSRSRSYSPRRRPSPRRRPSPRRRTPPRRMPPPPRHRRSRSPVRRRRRSSASLSGSSSSSSSSRSRSPPKKPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSPGRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQSSSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSPRKRQKETSPRGRRRRSPSPPPTRRRRSPSPAPPPRRRRTPTPPPRRRTPSPPPRRRSPSPRRYSPPIQRRYSPSPPPKRRTASPPPPPKRRASPSPPPKRRVSHSPPPKQRSSPVTKRRSPSLSSKHRKGSSPSRSTREARSPQPNKRHSPSPRPRAPQTSSSPPPVRRGASSSPQRRQSPSPSTRPIRRVSRTPEPKKIKKAASPSPQSVRRVSSSRSVSGSPEPAAKKPPAPPSPVQSQSPSTNWSPAVPVKKAKSPTPSPSPPRNSDQEGGGKKKKKKKDKKHKKDKKHKKHKKHKKEKAVAAAAAAAVTPAAIAAATTTLAQEEPVAAPEPKKETESEAEDNLDDLEKHLREKALRSMRKAQVSPQS
uniprot
proteins
function
FUNCTION: Part of pre- and post-splicing multiprotein mRNP complexes. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). Involved in numerous pre-mRNA processing events. Promotes constitutive and exonic splicing enhancer (ESE)-dependent splicing activation by bridging together sequence-specific (SR family proteins, SFRS4, SFRS5 and TRA2B/SFRS10) and basal snRNP (SNRP70 and SNRPA1) factors of the spliceosome. Stimulates mRNA 3'-end cleavage independently of the formation of an exon junction complex. Binds both pre-mRNA and spliced mRNA 20-25 nt upstream of exon-exon junctions. Binds RNA and DNA with low sequence specificity and has similar preference for either double- or single-stranded nucleic acid substrates. {ECO:0000269|PubMed:10339552, ECO:0000269|PubMed:10668804, ECO:0000269|PubMed:11739730, ECO:0000269|PubMed:12600940, ECO:0000269|PubMed:12944400, ECO:0000269|PubMed:9531537, ECO:0000305|PubMed:33509932}.
uniprot
proteins
mass_dalton
102335
uniprot
proteins
mutagenesis
MUTAGEN 20; /note="K->A: Strongly reduces DNA and RNA-binding."; /evidence="ECO:0000269|PubMed:12600940"; MUTAGEN 22; /note="K->A: Strongly reduces DNA and RNA-binding."; /evidence="ECO:0000269|PubMed:12600940"; MUTAGEN 23; /note="K->A: Strongly reduces DNA and RNA-binding."; /evidence="ECO:0000269|PubMed:12600940
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on multiple serine and threonine residues by DYRK3 during the G2-to-M transition, after the nuclear-envelope breakdown (PubMed:29973724). Phosphorylation by DYRK3 promotes disassembly of nuclear speckles (PubMed:29973724). {ECO:0000269|PubMed:29973724}.; PTM: Citrullinated by PADI4. {ECO:0000250|UniProtKB:Q52KI8}.
uniprot
proteins
protein_family
Splicing factor SR family
uniprot
proteins
pubmed
10339552
uniprot
proteins
pubmed
10668804
uniprot
proteins
pubmed
10809668
uniprot
proteins
pubmed
11118221
uniprot
proteins
pubmed
11546874
uniprot
proteins
pubmed
11739730
uniprot
proteins
pubmed
11991638
uniprot
proteins
pubmed
12093754
uniprot
proteins
pubmed
12600940
uniprot
proteins
pubmed
12624182
uniprot
proteins
pubmed
12944400
uniprot
proteins
pubmed
15024032
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
29973724
uniprot
proteins
pubmed
33509932
uniprot
proteins
pubmed
9531537
uniprot
proteins
sequence_length
904
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000269|PubMed:12624182, ECO:0000269|PubMed:9531537}. Nucleus speckle {ECO:0000269|PubMed:11546874, ECO:0000269|PubMed:9531537}.
uniprot
proteins