Rcn3
entrez
52377
canonical
uniprot
Q8BH97
canonical
ensembl
ENSMUSG00000019539
resolver
ensp
ENSMUSP00000019683
resolver
ensp
ENSMUSP00000147341
resolver
ensp
ENSMUSP00000148227
resolver
enst
ENSMUST00000019683
resolver
enst
ENSMUST00000211352
resolver
genesymbol
Rcn3
resolver
genesymbol_syn
D7Ertd671e
resolver
uniprot
Q58E50
resolver
uniprot
Q8R137
resolver
uniprot
Q99K35
resolver
uniprot
Q9CTD4
resolver
uniprot_entry
RCN3_MOUSE
resolver
uniprot_sec
Q58E50
resolver
uniprot_sec
Q8R137
resolver
uniprot_sec
Q99K35
resolver
uniprot_sec
Q9CTD4
resolver
amino_acid_sequence
MMWRWSFLLLLLLLRHWALGKPSPDAGPHGQDRVHHGTPLSEAPHDDAHGNFQYDHEAFLGRDVAKEFDKLSPEESQARLGRIVDRMDLAGDSDGWVSLAELRAWIAHTQQRHIRDSVSAAWHTYDTDRDGRVGWEELRNATYGHYEPGEEFHDVEDAETYKKMLARDERRFRVADQDGDSMATREELTAFLHPEEFPHMRDIVVAETLEDLDKNKDGYVQVEEYIADLYSEEPGEEEPAWVQTERQQFREFRDLNKDGRLDGSEVGYWVLPPSQDQPLVEANHLLHESDTDKDGRLSKAEILSNWNMFVGSQATNYGEDLTRHHDEL
uniprot
proteins
function
FUNCTION: Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (PubMed:26252542). Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3 (PubMed:26252542). By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (PubMed:26252542). Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens (By similarity). This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion (By similarity). {ECO:0000250|UniProtKB:Q96D15, ECO:0000269|PubMed:26252542}.
uniprot
proteins
mass_dalton
38002
uniprot
proteins
post_translational_modification
PTM: Degraded by PCSK6 and other endoproteases including FURIN and PCSK5. {ECO:0000250|UniProtKB:Q96D15}.; PTM: N-glycosylated. {ECO:0000250|UniProtKB:I6L9G5}.
uniprot
proteins
protein_family
CREC family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26252542
uniprot
proteins
sequence_length
328
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:26252542}.
uniprot
proteins