E9PUN6
uniprot
E9PUN6
canonical
amino_acid_sequence
MQLVSWATLLTLLVPDLVEMRSPDSAAAVRKDRLHPRQVKLLESLSEYEIASPIRVNPLGEPFPTNVHFKRRRRSINSASDPWPAFASSSSSSTSSQEHYRLSAFGQQFLFNLTAHTGFIAPLFTVTLLGEPGVNQTKLYSEEEMELRHCFYKGHVNTKSEHTAVISLCSGMMGTFRSHDGDYFIEPLQSVDEQEDEEEQNKPHIIYRHSTPQREPSTGKHACATSELKNSHSKDKRKIRMRKRRKRNSLADDVALLKSGLATKVLSGYSNQTNSTRDRWNHKRTKRFLSYPRFVEVMVVADHRMVLYHGANLQHYILTLMSIVASIYKDSSIGNLINIVIVNLVVIHNEQEGPYINFNAQTTLKNFCQWQHSKNYLGGIQHDTAVLVTREDICRAQDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDSNKCKEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPASRTYPLPSQLPGLLYNVNKQCELIFGPGSQVCPYMMQCRRLWCNNVDGAHKGCRTQHTPWADGTECEPGKHCKFGFCVPKEMEGPAIDGSWGGWSHFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKSCNTEPCMKQKRDFREEQCAHFDGKHFNINGLLPSVRWVPKYSGILMKDRCKLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHILNSKARKDKCGICGGDNSSCKTVAGTFNTVHYGYNTVVRIPAGATSIDVRQHSFSGKSEDDNYLALSNSKGEFLLNGDFVVSMSKREVRVGSAVIEYSGSDNVVERLNCTDRIEEELLLQVLSVGKLYNPDVRYSFNIPIEDKPQQFYWNSHGPWQACSKPCQGERRRKLVCTRESDQLTVSDQRCDRLPQPGPVTEACGTDCDLRWHVASKSECSAQCGLGYRTLDIHCAKYSRMDGKTEKVDDSFCSSQPRPSNQEKCSGECSTGGWRYSAWTECSRSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVVVQSCNEFSCPHWKTGDWSECLVTCGKGHKHRQVWCQFGEDRLSDRMCDPEAKPEPMQTCQQPECAAWQAGPWGQCSVTCGQGYQLRAVKCIMGTYMSVVDDNDCNAATRPTDTQDCELASCHPSILALEPRRNAQSIPRTQWRFGSWTPCSATCGKGTRMRYVSCRDEDGSVADESACATLPKPVAKEECSVTPCGQWKALDWSSCSVTCGQGKATRQVVCVNYSDHVIDRSECDPDYIPETDQDCSMSPCPQWTGLAHPFQNEDFRPRSDSPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCPQWAYGSWGECTKLCGGGMRTRLVVCQRANGDRFPDLSCEVLDKPTDREQCNTHACPQDAAWSTGPWSSCSVSCGRGHKHRNVYCLAKDGSHLESDNCKHLPKPHGHRRCRGGRCPRWKAGAWSQCSVSCGQGVQQRHVGCQIGTHKAARESECSSYSRPESERVCQASPCPLYTWRAEQWQQCTKTCGEGSRYRQVVCVAEDQSEVHSTHCDSDQRPPDRESCSLQPCEYVWITGEWSECSVTCGKGYRQRLVSCSEIYTGKENYEYSYQTTVNCPGAQPPSVHPCYLRDCPVSATWRVGNWGSCSVSCGIGVMHRSVQCLTNEDQPSHLCPTDTKPEERKACRNVYNCELPQNCKEVKKLNSASVDGEYFLAVRGKPLKVFCAGMNSDYPKEYVTLAHGDSENFSEVYGHRLHNPTECPYNGSRRDDCHCRKDYTAAGFSSFQKIRLDLTSMQIITTDLEFARTSEGHPVPFATAGDCYSAAKCPQGRFSINLYGTGLSLTESARWTSQGNYAVSDIKKSPDGTRVVGKCGGYCGKCTPSSGTGLEVRVS
uniprot
proteins
ec_number
3.4.24.-
uniprot
proteins
function
FUNCTION: Cleaves the large aggregating proteoglycans, aggrecan (at the '1838-Glu-|-Ala-1839' site) and versican (at the '1428-Glu-|-Ala-1429' site). In addition, catalyzes the shedding of the endopeptidase MMP14 (at the '314-Tyr-|-Gly-315' site), releasing the catalytic domain from the cell surface thereby preventing the downstream pro-MMP2 activation. Is involved in extracellular matrix proteolysis and in ciliary vesicle growth during ciliogenesis in metalloendopeptidase activity dependent manner. Has a protease-independent function in promoting the transport from the endoplasmic reticulum to the Golgi apparatus of a variety of secretory cargos. {ECO:0000250|UniProtKB:Q9P2N4}.
uniprot
proteins
mass_dalton
215753
uniprot
proteins
post_translational_modification
PTM: The precursor is cleaved by a furin endopeptidase. The secreted form is internalized, localizing to a subpopulation of late recycling endocytic vesicles targeted to the primary cilium in a highly dynamic process necessary for ciliogenesis. {ECO:0000250|UniProtKB:Q9P2N4}.; PTM: N-glycosylated (By similarity). Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity). {ECO:0000250|UniProtKB:Q76LX8, ECO:0000250|UniProtKB:Q9P2N4}.
uniprot
proteins
pubmed
18454205
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
30814516
uniprot
proteins
sequence_length
1931
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q9P2N4}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9P2N4}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9P2N4}. Recycling endosome {ECO:0000250|UniProtKB:Q9P2N4}. Note=Localized to the cilium base and surrounds the basal body. The secreted form is internalized, localizing to a subpopulation of late recycling endocytic vesicles targeted to the primary cilium in a highly dynamic process necessary for ciliogenesis. {ECO:0000250|UniProtKB:Q9P2N4}.
uniprot
proteins