Hace1
entrez
361866
canonical
uniprot
D3ZBM7
canonical
ensembl
ENSRNOG00000000327
resolver
ensembl
ENSRNOG00055000886
resolver
ensembl
ENSRNOG00060006397
resolver
ensembl
ENSRNOG00065000480
resolver
ensp
ENSRNOP00000000365
resolver
ensp
ENSRNOP00000085147
resolver
ensp
ENSRNOP00000090381
resolver
ensp
ENSRNOP00000104608
resolver
ensp
ENSRNOP00000107784
resolver
ensp
ENSRNOP00000110872
resolver
ensp
ENSRNOP00055001209
resolver
ensp
ENSRNOP00060007802
resolver
ensp
ENSRNOP00065000567
resolver
enst
ENSRNOT00000000365
resolver
enst
ENSRNOT00000106005
resolver
enst
ENSRNOT00000141456
resolver
enst
ENSRNOT00055001491
resolver
enst
ENSRNOT00060010523
resolver
enst
ENSRNOT00065000693
resolver
genesymbol
Hace1
resolver
uniprot
A0A8I6A1L8
resolver
uniprot
A0ABK0M0E2
resolver
uniprot
D3ZBM8
resolver
uniprot_entry
A0A8I6A1L8_RAT
resolver
uniprot_entry
A0ABK0M0E2_RAT
resolver
uniprot_entry
HACE1_RAT
resolver
uniprot_sec
D3ZBM8
resolver
activity_regulation
ACTIVITY REGULATION: Sterically autoinhibited in its dimeric state. {ECO:0000250|UniProtKB:Q8IYU2}.
uniprot
proteins
amino_acid_sequence
MERAMEQLNRLTRSLRRARTVELPEDNETAVYTLMPMVMADQHRSVSELLSNSKFDVNYAFGRVKRSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVTDVDVEDAMGQTALHVACQNGHKTTVQCLLDSGADINRPNVAGATPLYFACSHGQRDTAQILLLRGAKYLPDKNGVTPLDLCVQGGYGQTCEVLIQYHPRLFQTIVQMTQNEDLRENMLRQVLQHLSQQSESQYLKILTGLAEVATTNGHKLLSLSSSYEAQMKSLLRIVRIFCHVFRIGPSSPSNGMDMGYNGNKTPRSQVFKPLELLWHSLDEWLVLIATELMKNKEDSADITSILLKQKGQDQEASCISAFEPPGPGSYERLSTGPGESKPDVLAGKQEASADCQDVISVTANRLSAVIQAFYMCCSCQMPPGMTSPRFIEFVCKHDEVLKCFVNRNPKIIFDHFHFLLECPELMSRFMHIIKAQPFKDRCEWFYEHLHSGQPDSDMVHRPVSENDILLVHRDSIFRSSCEIVSKANCAKLKQGIAVRFHGEEGMGQGVVREWFDILSNEIVNPDYALFTQSADGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVNDWIKNTEYTSGYEREDPVIQWFWEVVEDMTQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGSYGYTMA
uniprot
proteins
ec_number
2.3.2.26
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases (By similarity). Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion (By similarity). Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division (By similarity). Specifically binds GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens (By similarity). May also act as a transcription regulator via its interaction with RARB (By similarity). {ECO:0000250|UniProtKB:Q3U0D9, ECO:0000250|UniProtKB:Q8IYU2}.
uniprot
proteins
mass_dalton
102159
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q8IYU2}.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. {ECO:0000250|UniProtKB:Q8IYU2}.
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
38332367
uniprot
proteins
sequence_length
909
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q8IYU2}. Cytoplasm {ECO:0000250|UniProtKB:Q8IYU2}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8IYU2}. Note=A significant portion localizes to the endoplasmic reticulum. Targeted to Golgi membrane via its interaction with Rab proteins. {ECO:0000250|UniProtKB:Q8IYU2}.
uniprot
proteins