BPI
entrez
671
canonical
uniprot
P17213
canonical
ensembl
ENSG00000101425
resolver
ensp
ENSP00000262865
resolver
ensp
ENSP00000409833
resolver
ensp
ENSP00000494528
resolver
ensp
ENSP00000520600
resolver
ensp
ENSP00000618494
resolver
enst
ENST00000262865
resolver
enst
ENST00000642449
resolver
enst
ENST00000716802
resolver
genesymbol
BPI
resolver
hgnc
HGNC:1095
resolver
uniprot
A0A2R8YDF1
resolver
uniprot
B2RCY2
resolver
uniprot
Q1ZZU8
resolver
uniprot
Q5JRW0
resolver
uniprot
Q8IW58
resolver
uniprot
Q9BYZ9
resolver
uniprot
Q9H1L2
resolver
uniprot
Q9H1M8
resolver
uniprot
Q9H203
resolver
uniprot
Q9UCT4
resolver
uniprot
Q9UD65
resolver
uniprot_entry
A0A2R8YDF1_HUMAN
resolver
uniprot_entry
BPI_HUMAN
resolver
uniprot_sec
B2RCY2
resolver
uniprot_sec
Q1ZZU8
resolver
uniprot_sec
Q5JRW0
resolver
uniprot_sec
Q8IW58
resolver
uniprot_sec
Q9BYZ9
resolver
uniprot_sec
Q9H1L2
resolver
uniprot_sec
Q9H1M8
resolver
uniprot_sec
Q9H203
resolver
uniprot_sec
Q9UCT4
resolver
uniprot_sec
Q9UD65
resolver
amino_acid_sequence
MRENMARGPCNAPRWASLMVLVAIGTAVTAAVNPGVVVRISQKGLDYASQQGTAALQKELKRIKIPDYSDSFKIKHLGKGHYSFYSMDIREFQLPSSQISMVPNVGLKFSISNANIKISGKWKAQKRFLKMSGNFDLSIEGMSISADLKLGSNPTSGKPTITCSSCSSHINSVHVHISKSKVGWLIQLFHKKIESALRNKMNSQVCEKVTNSVSSELQPYFQTLPVMTKIDSVAGINYGLVAPPATTAETLDVQMKGEFYSENHHNPPPFAPPVMEFPAAHDRMVYLGLSDYFFNTAGLVYQEAGVLKMTLRDDMIPKESKFRLTTKFFGTFLPEVAKKFPNMKIQIHVSASTPPHLSVQPTGLTFYPAVDVQAFAVLPNSSLASLFLIGMHTTGSMEVSAESNRLVGELKLDRLLLELKHSNIGPFPVELLQDIMNYIVPILVLPRVNEKLQKGFPLPTPARVQLYNVVLQPHQNFLLFGADVVYK
uniprot
proteins
function
FUNCTION: The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. {ECO:0000269|PubMed:1937776, ECO:0000269|PubMed:2722846}.
uniprot
proteins
mass_dalton
53900
uniprot
proteins
mutagenesis
MUTAGEN 49; /note="S->C: No impairment of secretion and increased propensity for dimer formation."; /evidence="ECO:0000269|PubMed:8812832"; MUTAGEN 163; /note="C->A: No impairment of secretion and/or biological activity. Loss of dimer formation."; /evidence="ECO:0000269|PubMed:8812832"; MUTAGEN 166; /note="C->S: Poorly secreted. Loss of LPS-binding and biological activity."; /evidence="ECO:0000269|PubMed:8812832"; MUTAGEN 206; /note="C->A: Not secreted."; /evidence="ECO:0000269|PubMed:8812832
uniprot
proteins
protein_family
BPI/LBP family
uniprot
proteins
protein_family
BPI/LBP/Plunc superfamily
uniprot
proteins
pubmed
10843855
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1937776
uniprot
proteins
pubmed
2501794
uniprot
proteins
pubmed
2722846
uniprot
proteins
pubmed
3667613
uniprot
proteins
pubmed
7517398
uniprot
proteins
pubmed
8812832
uniprot
proteins
pubmed
9188532
uniprot
proteins
sequence_length
487
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8812832}. Cytoplasmic granule membrane {ECO:0000269|PubMed:2722846}. Note=Membrane-associated in polymorphonuclear Leukocytes (PMN) granules. {ECO:0000269|PubMed:2722846}.
uniprot
proteins