CPEB3
entrez
22849
canonical
uniprot
Q8NE35
canonical
ensembl
ENSG00000107864
resolver
ensp
ENSP00000265997
resolver
ensp
ENSP00000398310
resolver
ensp
ENSP00000573922
resolver
ensp
ENSP00000573925
resolver
ensp
ENSP00000573926
resolver
ensp
ENSP00000573927
resolver
ensp
ENSP00000573929
resolver
ensp
ENSP00000573931
resolver
ensp
ENSP00000573935
resolver
ensp
ENSP00000573937
resolver
ensp
ENSP00000573938
resolver
ensp
ENSP00000573941
resolver
ensp
ENSP00000582246
resolver
ensp
ENSP00000616476
resolver
ensp
ENSP00000659875
resolver
genesymbol
CPEB3
resolver
genesymbol_syn
KIAA0940
resolver
hgnc
HGNC:21746
resolver
uniprot
B3KXC1
resolver
uniprot
Q5QP71
resolver
uniprot
Q5T389
resolver
uniprot
Q9NQJ7
resolver
uniprot
Q9Y2E9
resolver
uniprot_entry
B3KXC1_HUMAN
resolver
uniprot_entry
CPEB3_HUMAN
resolver
uniprot_entry
Q5QP71_HUMAN
resolver
uniprot_sec
Q5T389
resolver
uniprot_sec
Q9NQJ7
resolver
uniprot_sec
Q9Y2E9
resolver
amino_acid_sequence
MQDDLLMDKSKTQPQPQQQQRQQQQPQPESSVSEAPSTPLSSETPKPEENSAVPALSPAAAPPAPNGPDKMQMESPLLPGLSFHQPPQQPPPPQEPAAPGASLSPSFGSTWSTGTTNAVEDSFFQGITPVNGTMLFQNFPHHVNPVFGGTFSPQIGLAQTQHHQQPPPPAPAPQPAQPAQPPQAQPPQQRRSPASPSQAPYAQRSAAAAYGHQPIMTSKPSSSSAVAAAAAAAAASSASSSWNTHQSVNAAWSAPSNPWGGLQAGRDPRRAVGVGVGVGVGVPSPLNPISPLKKPFSSNVIAPPKFPRAAPLTSKSWMEDNAFRTDNGNNLLPFQDRSRPYDTFNLHSLENSLMDMIRTDHEPLKGKHYPPSGPPMSFADIMWRNHFAGRMGINFHHPGTDNIMALNNAFLDDSHGDQALSSGLSSPTRCQNGERVERYSRKVFVGGLPPDIDEDEITASFRRFGPLVVDWPHKAESKSYFPPKGYAFLLFQEESSVQALIDACLEEDGKLYLCVSSPTIKDKPVQIRPWNLSDSDFVMDGSQPLDPRKTIFVGGVPRPLRAVELAMIMDRLYGGVCYAGIDTDPELKYPKGAGRVAFSNQQSYIAAISARFVQLQHNDIDKRVEVKPYVLDDQMCDECQGTRCGGKFAPFFCANVTCLQYYCEYCWASIHSRAGREFHKPLVKEGGDRPRHVPFRWS
uniprot
proteins
function
FUNCTION: Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstimulated state but, following neuronal stimulation, acts as a translational activator (By similarity). In contrast to CPEB1, does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3'-UTR, but binds to a U-rich loop within a stem-loop structure (By similarity). Required for the consolidation and maintenance of hippocampal-based long term memory (By similarity). In the basal state, binds to the mRNA 3'-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively regulates their translation (By similarity). Also represses the translation of DLG4, GRIN1, GRIN2A and GRIN2B (By similarity). When activated, acts as a translational activator of GRIA1 and GRIA2 (By similarity). In the basal state, suppresses SUMO2 translation but activates it following neuronal stimulation (By similarity). Binds to the 3'-UTR of TRPV1 mRNA and represses TRPV1 translation which is required to maintain normal thermoception (By similarity). Binds actin mRNA, leading to actin translational repression in the basal state and to translational activation following neuronal stimulation (By similarity). Negatively regulates target mRNA levels by binding to TOB1 which recruits CNOT7/CAF1 to a ternary complex and this leads to target mRNA deadenylation and decay (PubMed:21336257). In addition to its role in translation, binds to and inhibits the transcriptional activation activity of STAT5B without affecting its dimerization or DNA-binding activity. This, in turn, represses transcription of the STAT5B target gene EGFR which has been shown to play a role in enhancing learning and memory performance (PubMed:20639532). In contrast to CPEB1, CPEB2 and CPEB4, not required for cell cycle progression (PubMed:26398195). {ECO:0000250|UniProtKB:Q7TN99, ECO:0000269|PubMed:20639532, ECO:0000269|PubMed:21336257, ECO:0000269|PubMed:26398195}.
uniprot
proteins
mass_dalton
76014
uniprot
proteins
mutagenesis
MUTAGEN 349; /note="L->A: Abolishes nuclear export; when associated with A-353."; /evidence="ECO:0000269|PubMed:22730302"; MUTAGEN 353; /note="L->A: Abolishes nuclear export; when associated with A-349."; /evidence="ECO:0000269|PubMed:22730302"; MUTAGEN 441; /note="R->A: Does not impair RNA binding."; /evidence="ECO:0000269|PubMed:24343026"; MUTAGEN 444; /note="F->A,N: Abolishes RNA binding."; /evidence="ECO:0000269|PubMed:24343026"; MUTAGEN 444; /note="F->Y: Does not impair RNA binding."; /evidence="ECO:0000269|PubMed:24343026"; MUTAGEN 446; /note="G->A: Does not impair RNA binding."; /evidence="ECO:0000269|PubMed:24343026"; MUTAGEN 463; /note="R->A: Does not impair RNA binding."; /evidence="ECO:0000269|PubMed:24343026"; MUTAGEN 470; /note="D->A: Does not impair RNA binding."; /evidence="ECO:0000269|PubMed:24343026"; MUTAGEN 474; /note="K->A: Does not impair RNA binding."; /evidence="ECO:0000269|PubMed:24343026"; MUTAGEN 479; /note="S->A: Does not impair RNA binding."; /evidence="ECO:0000269|PubMed:24343026"; MUTAGEN 488; /note="F->A: Reduced RNA binding."; /evidence="ECO:0000269|PubMed:24343026"; MUTAGEN 488; /note="F->Y: Does not impair RNA binding."; /evidence="ECO:0000269|PubMed:24343026"; MUTAGEN 528; /note="R->A: Does not impair RNA binding."; /evidence="ECO:0000269|PubMed:24343026
uniprot
proteins
post_translational_modification
PTM: Activated by NEURL1-mediated monoubiquitination, resulting in the growth of new dendritic spines and increased levels of GRIA1 and GRIA2. NEURL1-mediated monoubiquitination facilitates synaptic plasticity and hippocampal-dependent memory storage. {ECO:0000250|UniProtKB:Q7TN99}.; PTM: Under basal unstimulated conditions when CPEB3 is mainly unaggregated, sumoylated and acts as a translational repressor. Following neuronal stimulation, becomes desumoylated and aggregated which is required for the translation of mRNA targets and for dendritic filopodia formation. {ECO:0000250|UniProtKB:Q7TN99}.; PTM: Following neuronal stimulation, cleaved by CAPN2 which abolishes its translational repressor activity, leading to translation of CPEB3 target mRNAs. {ECO:0000250|UniProtKB:Q7TN99}.; PTM: Phosphorylation is enhanced by neuronal stimulation. {ECO:0000250|UniProtKB:Q7TN99}.
uniprot
proteins
protein_family
RRM CPEB family
uniprot
proteins
pubmed
10231032
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16990549
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19503753
uniprot
proteins
pubmed
20639532
uniprot
proteins
pubmed
21336257
uniprot
proteins
pubmed
22730302
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24343026
uniprot
proteins
pubmed
25066254
uniprot
proteins
pubmed
26398195
uniprot
proteins
sequence_length
698
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20639532, ECO:0000269|PubMed:22730302}. Nucleus {ECO:0000269|PubMed:20639532, ECO:0000269|PubMed:22730302}. Synapse {ECO:0000250|UniProtKB:Q7TN99}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q7TN99}. Postsynaptic density {ECO:0000250|UniProtKB:Q7TN99}. Note=Predominantly cytoplasmic in unstimulated neurons but translocates to the nucleus following neuronal stimulation (PubMed:20639532, PubMed:22730302). Nuclear import is mediated by importin IPO5 (By similarity). {ECO:0000250|UniProtKB:Q7TN99, ECO:0000269|PubMed:20639532, ECO:0000269|PubMed:22730302}.
uniprot
proteins