Serpine1
entrez
24617
canonical
uniprot
P20961
canonical
ensembl
ENSRNOG00000001414
resolver
ensembl
ENSRNOG00055000166
resolver
ensembl
ENSRNOG00060012143
resolver
ensembl
ENSRNOG00065001606
resolver
ensp
ENSRNOP00000001916
resolver
ensp
ENSRNOP00055000151
resolver
ensp
ENSRNOP00060016231
resolver
ensp
ENSRNOP00065001504
resolver
enst
ENSRNOT00000001916
resolver
enst
ENSRNOT00055000256
resolver
enst
ENSRNOT00060020611
resolver
enst
ENSRNOT00065002155
resolver
genesymbol
Serpine1
resolver
genesymbol_syn
Pai1
resolver
genesymbol_syn
Planh1
resolver
uniprot
F1LM16
resolver
uniprot_entry
F1LM16_RAT
resolver
uniprot_entry
PAI1_RAT
resolver
amino_acid_sequence
MQMSSALTCLTLGLVLVFGKGFASPLPESHTAQQATNFGVKVFQHVVQASKDRNVVFSPYGVSSVLAMLQLTTAGKTRQQIQDAMGFNISERGTAPALRKLSKELMGSWNKNEISTADAIFVQRDLELVQGFMPHFFKLFRTTVKQVDFSEVERARFIINDWVERHTKGMISDLLAKGAVNELTRLVLVNALYFNGQWKTPFLEASTHQRLFHKSDGSTISVPMMAQNNKFNYTEFTTPDGHEYDILELPYHGETLSMFIAAPFEKDVPLSAITNILDAELIRQWKSNMTRLPRLLILPKFSLETEVDLRGPLEKLGMTDIFSSTQADFTSLSDQEQLSVAQALQKVKIEVNESGTVASSSTAILVSARMAPTEMVLDRSFLFVVRHNPTETILFMGQLMEP
uniprot
proteins
function
FUNCTION: Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence (By similarity). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (By similarity). {ECO:0000250|UniProtKB:P05121, ECO:0000250|UniProtKB:P22777}.
uniprot
proteins
mass_dalton
45010
uniprot
proteins
protein_family
Serpin family
uniprot
proteins
pubmed
2298740
uniprot
proteins
pubmed
28722352
uniprot
proteins
pubmed
3149611
uniprot
proteins
sequence_length
402
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P05121}.
uniprot
proteins