Tlr3
entrez
142980
canonical
uniprot
Q99MB1
canonical
ensembl
ENSMUSG00000031639
resolver
ensp
ENSMUSP00000034056
resolver
ensp
ENSMUSP00000126556
resolver
ensp
ENSMUSP00000147738
resolver
ensp
ENSMUSP00000202878
resolver
ensp
ENSMUSP00000202879
resolver
ensp
ENSMUSP00000363764
resolver
ensp
ENSMUSP00000363765
resolver
enst
ENSMUST00000034056
resolver
enst
ENSMUST00000167106
resolver
enst
ENSMUST00000209772
resolver
genesymbol
Tlr3
resolver
uniprot
Q91ZM4
resolver
uniprot_entry
TLR3_MOUSE
resolver
uniprot_sec
Q91ZM4
resolver
amino_acid_sequence
MKGCSSYLMYSFGGLLSLWILLVSSTNQCTVRYNVADCSHLKLTHIPDDLPSNITVLNLTHNQLRRLPPTNFTRYSQLAILDAGFNSISKLEPELCQILPLLKVLNLQHNELSQISDQTFVFCTNLTELDLMSNSIHKIKSNPFKNQKNLIKLDLSHNGLSSTKLGTGVQLENLQELLLAKNKILALRSEELEFLGNSSLRKLDLSSNPLKEFSPGCFQTIGKLFALLLNNAQLNPHLTEKLCWELSNTSIQNLSLANNQLLATSESTFSGLKWTNLTQLDLSYNNLHDVGNGSFSYLPSLRYLSLEYNNIQRLSPRSFYGLSNLRYLSLKRAFTKQSVSLASHPNIDDFSFQWLKYLEYLNMDDNNIPSTKSNTFTGLVSLKYLSLSKTFTSLQTLTNETFVSLAHSPLLTLNLTKNHISKIANGTFSWLGQLRILDLGLNEIEQKLSGQEWRGLRNIFEIYLSYNKYLQLSTSSFALVPSLQRLMLRRVALKNVDISPSPFRPLRNLTILDLSNNNIANINEDLLEGLENLEILDFQHNNLARLWKRANPGGPVNFLKGLSHLHILNLESNGLDEIPVGVFKNLFELKSINLGLNNLNKLEPFIFDDQTSLRSLNLQKNLITSVEKDVFGPPFQNLNSLDMRFNPFDCTCESISWFVNWINQTHTNISELSTHYLCNTPHHYYGFPLKLFDTSSCKDSAPFELLFIISTSMLLVFILVVLLIHIEGWRISFYWNVSVHRILGFKEIDTQAEQFEYTAYIIHAHKDRDWVWEHFSPMEEQDQSLKFCLEERDFEAGVLGLEAIVNSIKRSRKIIFVITHHLLKDPLCRRFKVHHAVQQAIEQNLDSIILIFLQNIPDYKLNHALCLRRGMFKSHCILNWPVQKERINAFHHKLQVALGSRNSAH
uniprot
proteins
function
FUNCTION: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response (By similarity). {ECO:0000250, ECO:0000269|PubMed:14993594}.
uniprot
proteins
mass_dalton
103671
uniprot
proteins
post_translational_modification
PTM: TLR3 signaling requires a proteolytic cleavage mediated by cathepsins CTSB and CTSH, the cleavage occurs between amino acids 252 and 346. The cleaved form of TLR3 is the predominant form found in endosomes (By similarity). {ECO:0000250}.; PTM: Ubiquitinated by TRIM3; leading to recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes. Ubiquitinated by ZNRF1 via 'Lys-63'-linked ubiquitin chains; leading to TLR3 lysosomal trafficking and degradation. {ECO:0000250|UniProtKB:O15455}.
uniprot
proteins
protein_family
Toll-like receptor family
uniprot
proteins
pubmed
11607032
uniprot
proteins
pubmed
14993594
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17452530
uniprot
proteins
pubmed
18420935
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25736436
uniprot
proteins
pubmed
31076723
uniprot
proteins
pubmed
33432245
uniprot
proteins
sequence_length
905
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane {ECO:0000250|UniProtKB:O15455}. Early endosome {ECO:0000250|UniProtKB:O15455}.
uniprot
proteins
transmembrane_region
TRANSMEM 706..726; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins