EIF6
entrez
3692
canonical
uniprot
P56537
canonical
ensembl
ENSG00000242372
resolver
ensp
ENSP00000363559
resolver
ensp
ENSP00000363566
resolver
ensp
ENSP00000363574
resolver
ensp
ENSP00000502429
resolver
genesymbol
EIF6
resolver
genesymbol_syn
EIF3A
resolver
genesymbol_syn
ITGB4BP
resolver
hgnc
HGNC:6159
resolver
uniprot
B7ZBG9
resolver
uniprot
Q6IBN8
resolver
uniprot
Q96TD5
resolver
uniprot_entry
IF6_HUMAN
resolver
uniprot_sec
B7ZBG9
resolver
uniprot_sec
Q6IBN8
resolver
uniprot_sec
Q96TD5
resolver
amino_acid_sequence
MAVRASFENNCEIGCFAKLTNTYCLVAIGGSENFYSVFEGELSDTIPVVHASIAGCRIIGRMCVGNRHGLLVPNNTTDQELQHIRNSLPDTVQIRRVEERLSALGNVTTCNDYVALVHPDLDRETEEILADVLKVEVFRQTVADQVLVGSYCVFSNQGGLVHPKTSIEDQDELSSLLQVPLVAGTVNRGSEVIAAGMVVNDWCAFCGLDTTSTELSVVESVFKLNEAQPSTIATSMRDSLIDSLT
uniprot
proteins
function
FUNCTION: Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm (PubMed:10085284, PubMed:14654845, PubMed:21536732, PubMed:32669547). Behaves as a stimulatory translation initiation factor downstream insulin/growth factors. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export. Cytoplasmic release of TIF6 from 60S subunits and nuclear relocalization is promoted by a RACK1 (RACK1)-dependent protein kinase C activity (PubMed:10085284, PubMed:14654845, PubMed:21536732). In tissues responsive to insulin, controls fatty acid synthesis and glycolysis by exerting translational control of adipogenic transcription factors such as CEBPB, CEBPD and ATF4 that have G/C rich or uORF in their 5'UTR. Required for ROS-dependent megakaryocyte maturation and platelets formation, controls the expression of mitochondrial respiratory chain genes involved in reactive oxygen species (ROS) synthesis (By similarity). Involved in miRNA-mediated gene silencing by the RNA-induced silencing complex (RISC). Required for both miRNA-mediated translational repression and miRNA-mediated cleavage of complementary mRNAs by RISC (PubMed:17507929). Modulates cell cycle progression and global translation of pre-B cells, its activation seems to be rate-limiting in tumorigenesis and tumor growth (By similarity). {ECO:0000255|HAMAP-Rule:MF_03132, ECO:0000269|PubMed:10085284, ECO:0000269|PubMed:14654845, ECO:0000269|PubMed:17507929, ECO:0000269|PubMed:21536732, ECO:0000269|PubMed:32669547}.
uniprot
proteins
mass_dalton
26599
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-174 and Ser-175 by CSNK1D/CK1 promotes nuclear export. {ECO:0000269|PubMed:12917340, ECO:0000269|PubMed:14654845, ECO:0000269|PubMed:21084295}.; PTM: Ufmylated by UFL1. {ECO:0000250|UniProtKB:O55135}.
uniprot
proteins
protein_family
EIF-6 family
uniprot
proteins
pubmed
10085284
uniprot
proteins
pubmed
11290417
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12917340
uniprot
proteins
pubmed
14654845
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
17507929
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21084295
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21536732
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
32669547
uniprot
proteins
pubmed
9374518
uniprot
proteins
pubmed
9405604
uniprot
proteins
pubmed
9653160
uniprot
proteins
sequence_length
245
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus, nucleolus. Note=Shuttles between cytoplasm and nucleus/nucleolus.
uniprot
proteins