BCDIN3D
entrez
144233
canonical
uniprot
Q7Z5W3
canonical
ensembl
ENSG00000186666
resolver
ensp
ENSP00000335201
resolver
enst
ENST00000333924
resolver
genesymbol
BCDIN3D
resolver
hgnc
HGNC:27050
resolver
uniprot
A8K829
resolver
uniprot_entry
BN3D2_HUMAN
resolver
uniprot_sec
A8K829
resolver
amino_acid_sequence
MAVPTELDGGSVKETAAEEESRVLAPGAAPFGNFPHYSRFHPPEQRLRLLPPELLRQLFPESPENGPILGLDVGCNSGDLSVALYKHFLSLPDGETCSDASREFRLLCCDIDPVLVKRAEKECPFPDALTFITLDFMNQRTRKVLLSSFLSQFGRSVFDIGFCMSITMWIHLNHGDHGLWEFLAHLSSLCHYLLVEPQPWKCYRAAARRLRKLGLHDFDHFHSLAIRGDMPNQIVQILTQDHGMELICCFGNTSWDRSLLLFRAKQTIETHPIPESLIEKGKEKNRLSFQKQ
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: O-methyltransferase that specifically monomethylates 5'-monophosphate of cytoplasmic histidyl tRNA (tRNA(His)), acting as a capping enzyme by protecting tRNA(His) from cleavage by DICER1 (PubMed:28119416, PubMed:31329584, PubMed:31919512). Also able, with less efficiently, to methylate the 5' monophosphate of a subset of pre-miRNAs, acting as a negative regulator of miRNA processing (PubMed:23063121, PubMed:28119416). The 5' monophosphate of pre-miRNAs is recognized by DICER1 and is required for pre-miRNAs processing: methylation at this position reduces the processing of pre-miRNAs by DICER1 (PubMed:23063121). Was also reported to mediate dimethylation of pre-miR-145; however dimethylation cannot be reproduced by another group which observes a monomethylation of pre-miR-145 (PubMed:23063121, PubMed:28119416). {ECO:0000269|PubMed:23063121, ECO:0000269|PubMed:28119416, ECO:0000269|PubMed:31329584, ECO:0000269|PubMed:31919512}.
uniprot
proteins
mass_dalton
33200
uniprot
proteins
mutagenesis
MUTAGEN 37; /note="Y->A,F: Abolished O-methyltransferase activity."; /evidence="ECO:0000269|PubMed:31919512"; MUTAGEN 46; /note="R->A: Abolished O-methyltransferase activity."; /evidence="ECO:0000269|PubMed:31919512"; MUTAGEN 72..74; /note="DVG->AVA: Abolished O-methyltransferase activity."; /evidence="ECO:0000269|PubMed:23063121, ECO:0000269|PubMed:28119416, ECO:0000269|PubMed:31919512"; MUTAGEN 72; /note="D->A: Abolished O-methyltransferase activity."; /evidence="ECO:0000269|PubMed:31919512"; MUTAGEN 74; /note="G->A: Abolished O-methyltransferase activity."; /evidence="ECO:0000269|PubMed:31919512"; MUTAGEN 76; /note="N->A: Abolished O-methyltransferase activity."; /evidence="ECO:0000269|PubMed:31919512"; MUTAGEN 110; /note="D->A: Abolished O-methyltransferase activity."; /evidence="ECO:0000269|PubMed:31919512"; MUTAGEN 111; /note="I->G: Decreased O-methyltransferase activity."; /evidence="ECO:0000269|PubMed:31919512"; MUTAGEN 118; /note="R->A: Slightly decreased O-methyltransferase activity."; /evidence="ECO:0000269|PubMed:31919512"; MUTAGEN 135; /note="D->A: Decreased O-methyltransferase activity."; /evidence="ECO:0000269|PubMed:31919512"; MUTAGEN 136; /note="F->G: Abolished O-methyltransferase activity."; /evidence="ECO:0000269|PubMed:31919512"; MUTAGEN 165; /note="S->A: Decreased O-methyltransferase activity."; /evidence="ECO:0000269|PubMed:31919512"; MUTAGEN 166; /note="I->G: Decreased O-methyltransferase activity."; /evidence="ECO:0000269|PubMed:31919512"; MUTAGEN 169; /note="W->F: Abolished O-methyltransferase activity."; /evidence="ECO:0000269|PubMed:31919512"; MUTAGEN 198; /note="Q->A: Abolished O-methyltransferase activity."; /evidence="ECO:0000269|PubMed:31919512"; MUTAGEN 201..204; /note="KCYR->ACYA: Abolished O-methyltransferase activity."; /evidence="ECO:0000269|PubMed:31919512"; MUTAGEN 201; /note="K->A: Decreased O-methyltransferase activity."; /evidence="ECO:0000269|PubMed:31919512"; MUTAGEN 204; /note="R->A: Decreased O-methyltransferase activity."; /evidence="ECO:0000269|PubMed:31919512"; MUTAGEN 208..209; /note="RR->AA: Abolished O-methyltransferase activity."; /evidence="ECO:0000269|PubMed:31919512"; MUTAGEN 208; /note="R->A: Strongly decreased O-methyltransferase activity."; /evidence="ECO:0000269|PubMed:31919512"; MUTAGEN 209; /note="R->A: Abolished O-methyltransferase activity."; /evidence="ECO:0000269|PubMed:31919512"; MUTAGEN 211..212; /note="RK->AA: Abolished O-methyltransferase activity."; /evidence="ECO:0000269|PubMed:31919512"; MUTAGEN 211; /note="R->A: Abolished O-methyltransferase activity."; /evidence="ECO:0000269|PubMed:31919512"; MUTAGEN 212; /note="K->A: Decreased O-methyltransferase activity."; /evidence="ECO:0000269|PubMed:31919512"; MUTAGEN 257; /note="R->A: Abolished O-methyltransferase activity."; /evidence="ECO:0000269|PubMed:31919512
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23063121
uniprot
proteins
pubmed
28119416
uniprot
proteins
pubmed
30127802
uniprot
proteins
pubmed
31329584
uniprot
proteins
pubmed
31919512
uniprot
proteins
sequence_length
292
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23063121}.
uniprot
proteins