Parpbp
entrez
100310874
canonical
uniprot
Q9EQ10
canonical
ensembl
ENSRNOG00000004682
resolver
ensembl
ENSRNOG00055021645
resolver
ensembl
ENSRNOG00060022376
resolver
ensembl
ENSRNOG00065022855
resolver
ensp
ENSRNOP00000006174
resolver
ensp
ENSRNOP00000006249
resolver
ensp
ENSRNOP00000060859
resolver
enst
ENSRNOT00000006174
resolver
genesymbol
Parpbp
resolver
genesymbol_syn
Arom
resolver
genesymbol_syn
Pari
resolver
uniprot
G3V6L0
resolver
uniprot_entry
G3V6L0_RAT
resolver
uniprot_entry
PARI_RAT
resolver
amino_acid_sequence
MAVLNQMSVLDMIKAFRRNWRAHCNSERTTLCGPDSMLLALQLSMAENNKQHHGEFTVCLSDVLLTWKYFLHEKLNLPIENMKVVDHYEDIRKTYDDFLKNSNTLDLIDVYKKCSIMTSNCEKHMISSIQLRDFLSGTECAVNDENNPHSPASPVKCSQNDKQVRLLAKKIFLSYLSLLVNSKNDLALAQILNTPDRGLGREAFTNLKHAAREKQLSMFLMATSFIRTLELGGKGYAPPPSDPLWAHVKGLSAFVNFIDKLNEILGEVPNPSLAGGRILSAIRTQLIKGHSSGEPFYKAVEEVVQDLNLRIKNIINSQEGVTVSATNISPVPPKSFAINHDTAYCGRDAVKILLVLLDEDAASAPTRNKAELLYNDQSTAPHGGASVLTLFRSPTQVKSTPVKPLRERIHTSLQAEKNKQMRQTLIRSQFACTYKDDCIMSKSKWNVNSSSKPLSALRLENDVSEGAQPSVGKARLETSSENVHVDRSKDDKGPRKSTKRKLAKSKQPGVREDIHCDQGDELYQPKNVKILKVPSDSHRKAGGKLAPGARGNRCTTKDKLIPGQTKLTRFFML
uniprot
proteins
function
FUNCTION: Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect (By similarity). Binds single-strand DNA and poly(A) homopolymers. {ECO:0000250, ECO:0000269|PubMed:11006283}.
uniprot
proteins
mass_dalton
63902
uniprot
proteins
protein_family
PARI family
uniprot
proteins
pubmed
11006283
uniprot
proteins
sequence_length
573
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11006283}. Nucleus {ECO:0000269|PubMed:11006283}. Note=Localizes to chromatin in response to S phase arrest but not in mitosis. Targeted to chromatin via its interaction with PCNA (By similarity). {ECO:0000250}.
uniprot
proteins