Casq2
entrez
29209
canonical
uniprot
P51868
canonical
ensembl
ENSRNOG00000016243
resolver
ensp
ENSRNOP00000086716
resolver
genesymbol
Casq2
resolver
uniprot
O09177
resolver
uniprot
Q6IMX1
resolver
uniprot_entry
CASQ2_RAT
resolver
uniprot_sec
O09177
resolver
uniprot_sec
Q6IMX1
resolver
amino_acid_sequence
MKRIYLLVVGLYLLSFSRAEEGLNFPTYDGKDRVVSLSEKNLKQVLKRYDLLCLYYHEPVSSDKVAQKQFQLKEIVLELVAQVLEHKNIGFVMVDSRKEAKLAKRLGFSEEGSLYVLKGGRTIEFDGEFAADVLVEFLLDLIEDPVEIVNNKLEVQAFERIEDQIKLLGFFKNEDSEYYKAFQEAAEHFQPYIKFFATFDKGVAKKLSLKMNEVGFYEPFMDEPSVIPNKPYTEEELVEFVKEHQRPTLRPLRPEDMFETWEDDLNGIHIVAFAEKSDPDGYEFLEILKQVARDNTDNPDLSILWIDPDDFPLLVAYWEKTFKIDLFKPQIGVVNVTDADSVWMEIPDDDDLPTAEELEDWIEDVLSGKINTEDDDNEDEDDDGDNDNDDDDDDDDNSDEDNDDSDDDDDDDE
uniprot
proteins
function
FUNCTION: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle (PubMed:8042990). Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats (By similarity). {ECO:0000250|UniProtKB:O14958, ECO:0000269|PubMed:8042990}.
uniprot
proteins
mass_dalton
47839
uniprot
proteins
post_translational_modification
PTM: Phosphorylation in the C-terminus, probably by CK2, moderately increases calcium buffering capacity. {ECO:0000269|PubMed:21431367}.; PTM: N-glycosylated. {ECO:0000250|UniProtKB:O14958}.
uniprot
proteins
protein_family
Calsequestrin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21431367
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8042990
uniprot
proteins
sequence_length
413
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Sarcoplasmic reticulum lumen {ECO:0000250|UniProtKB:O09161}. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of cardiac and slow skeletal muscle cells. {ECO:0000250|UniProtKB:O09161}.
uniprot
proteins