Il27
entrez
246779
canonical
uniprot
Q8K3I6
canonical
ensembl
ENSMUSG00000044701
resolver
ensp
ENSMUSP00000054637
resolver
enst
ENSMUST00000058429
resolver
genesymbol
Il27
resolver
genesymbol_syn
Il27a
resolver
uniprot_entry
IL27A_MOUSE
resolver
amino_acid_sequence
MGQVTGDLGWRLSLLLLPLLLVQAGSWGFPTDPLSLQELRREFTVSLYLARKLLSEVQGYVHSFAESRLPGVNLDLLPLGYHLPNVSLTFQAWHHLSDSERLCFLATTLRPFPAMLGGLGTQGTWTSSEREQLWAMRLDLRDLHRHLRFQVLAAGFKCSKEEEDKEEEEEEEEEEKKLPLGALGGPNQVSSQVSWPQLLYTYQLLHSLELVLSRAVRDLLLLSLPRRPGSAWDS
uniprot
proteins
function
FUNCTION: Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct pathways, p38 MAPK/TBX21- and ICAM1/ITGAL/ERK-dependent pathways. It also induces STAT1, STAT3, STAT4 and STAT5 phosphorylation and activates TBX21/T-Bet via STAT1 with resulting IL12RB2 up-regulation, an event crucial to TH1 cell commitment. It suppresses the expression of GATA3, the inhibitor TH1 cells development. In CD8 T-cells, it activates STATs as well as GZMB. IL-27 reveals to be a potent inhibitor of TH17 cell development and of IL-17 production. Indeed IL27 alone is also able to inhibit the production of IL17 by CD4 and CD8 T-cells. While IL-27 suppressed the development of pro-inflammatory Th17 cells via STAT1, it inhibits the development of anti-inflammatory inducible regulatory T-cells, iTreg, independently of STAT1. IL-27 also has an effect on cytokine production, it suppresses pro-inflammatory cytokine production such as IL2, IL4, IL5 and IL6 and activates suppressors of cytokine signaling such as SOCS1 and SOCS3. Apart from suppression of cytokine production, IL-27 also antagonizes the effects of some cytokines such as IL6 through direct effects on T-cells. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines such as IP-10/CXCL10 and MIG/CXCL9. {ECO:0000269|PubMed:12121660, ECO:0000269|PubMed:14565860, ECO:0000269|PubMed:14657353, ECO:0000269|PubMed:14871851, ECO:0000269|PubMed:15585838, ECO:0000269|PubMed:15688376, ECO:0000269|PubMed:16034109, ECO:0000269|PubMed:16365415, ECO:0000269|PubMed:16493033, ECO:0000269|PubMed:16751375, ECO:0000269|PubMed:16906166, ECO:0000269|PubMed:16906167, ECO:0000269|PubMed:17015723, ECO:0000269|PubMed:17114427, ECO:0000269|PubMed:17549733}.
uniprot
proteins
mass_dalton
26542
uniprot
proteins
post_translational_modification
PTM: O-glycosylated. {ECO:0000250}.
uniprot
proteins
protein_family
IL-6 superfamily
uniprot
proteins
pubmed
12121660
uniprot
proteins
pubmed
14565860
uniprot
proteins
pubmed
14657353
uniprot
proteins
pubmed
14871851
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15585838
uniprot
proteins
pubmed
15688376
uniprot
proteins
pubmed
15804443
uniprot
proteins
pubmed
16034109
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16365415
uniprot
proteins
pubmed
16493033
uniprot
proteins
pubmed
16751375
uniprot
proteins
pubmed
16906166
uniprot
proteins
pubmed
16906167
uniprot
proteins
pubmed
17015723
uniprot
proteins
pubmed
17114427
uniprot
proteins
pubmed
17294231
uniprot
proteins
pubmed
17548596
uniprot
proteins
pubmed
17549733
uniprot
proteins
pubmed
17709543
uniprot
proteins
pubmed
17727629
uniprot
proteins
sequence_length
234
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12121660}. Note=Poorly secreted without coexpression of EBI3.
uniprot
proteins