FNTA
entrez
2339
canonical
uniprot
P49354
canonical
ensembl
ENSG00000168522
resolver
ensp
ENSP00000303423
resolver
genesymbol
FNTA
resolver
hgnc
HGNC:3782
resolver
uniprot
A6NJW0
resolver
uniprot
Q53XJ9
resolver
uniprot
Q9UDC1
resolver
uniprot_entry
FNTA_HUMAN
resolver
uniprot_sec
A6NJW0
resolver
uniprot_sec
Q53XJ9
resolver
uniprot_sec
Q9UDC1
resolver
activity_regulation
ACTIVITY REGULATION: Activated by the AGRIN-induced phosphorylation which is mediated by MUSK. {ECO:0000250|UniProtKB:Q61239}.
uniprot
proteins
amino_acid_sequence
MAATEGVGEAAQGGEPGQPAQPPPQPHPPPPQQQHKEEMAAEAGEAVASPMDDGFVSLDSPSYVLYRDRAEWADIDPVPQNDGPNPVVQIIYSDKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLKSLQKDLHEEMNYITAIIEEQPKNYQVWHHRRVLVEWLRDPSQELEFIADILNQDAKNYHAWQHRQWVIQEFKLWDNELQYVDQLLKEDVRNNSVWNQRYFVISNTTGYNDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSKYPNLLNQLLDLQPSHSSPYLIAFLVDIYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHSTENDSPTNVQQ
uniprot
proteins
ec_number
2.5.1.58
uniprot
proteins
ec_number
2.5.1.59
uniprot
proteins
function
FUNCTION: Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation. {ECO:0000269|PubMed:12036349, ECO:0000269|PubMed:12825937, ECO:0000269|PubMed:16893176, ECO:0000269|PubMed:19246009, ECO:0000269|PubMed:8419339, ECO:0000269|PubMed:8494894}.
uniprot
proteins
mass_dalton
44409
uniprot
proteins
mutagenesis
MUTAGEN 164; /note="K->N: Reduced activity."; /evidence="ECO:0000269|PubMed:8419339"; MUTAGEN 199; /note="N->K: Reduced catalytic efficiency."; /evidence="ECO:0000269|PubMed:8494894
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation is mediated by MUSK upon AGRIN stimulation and results in the activation of FNTA (By similarity). {ECO:0000250|UniProtKB:Q61239}.
uniprot
proteins
protein_family
Protein prenyltransferase subunit alpha family
uniprot
proteins
pubmed
11687658
uniprot
proteins
pubmed
12036349
uniprot
proteins
pubmed
12825937
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15170324
uniprot
proteins
pubmed
15451670
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
16893176
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19246009
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
37316325
uniprot
proteins
pubmed
8276393
uniprot
proteins
pubmed
8419339
uniprot
proteins
pubmed
8494894
uniprot
proteins
sequence_length
379
uniprot
proteins