KIRREL3
entrez
84623
canonical
uniprot
Q8IZU9
canonical
ensembl
ENSG00000149571
resolver
ensp
ENSP00000434081
resolver
ensp
ENSP00000435094
resolver
ensp
ENSP00000435466
resolver
enst
ENST00000529097
resolver
genesymbol
KIRREL3
resolver
genesymbol_syn
KIAA1867
resolver
genesymbol_syn
NEPH2
resolver
hgnc
HGNC:23204
resolver
uniprot
E9PRX9
resolver
uniprot
Q3MIJ7
resolver
uniprot
Q6UWJ9
resolver
uniprot
Q6UWL5
resolver
uniprot
Q96JG0
resolver
uniprot_entry
E9PRX9_HUMAN
resolver
uniprot_entry
KIRR3_HUMAN
resolver
uniprot_sec
Q3MIJ7
resolver
uniprot_sec
Q6UWJ9
resolver
uniprot_sec
Q6UWL5
resolver
uniprot_sec
Q96JG0
resolver
amino_acid_sequence
MKPFQLDLLFVCFFLFSQELGLQKRGCCLVLGYMAKDKFRRMNEGQVYSFSQQPQDQVVVSGQPVTLLCAIPEYDGFVLWIKDGLALGVGRDLSSYPQYLVVGNHLSGEHHLKILRAELQDDAVYECQAIQAAIRSRPARLTVLVPPDDPVILGGPVISLRAGDPLNLTCHADNAKPAASIIWLRKGEVINGATYSKTLLRDGKRESIVSTLFISPGDVENGQSIVCRATNKAIPGGKETSVTIDIQHPPLVNLSVEPQPVLEDNVVTFHCSAKANPAVTQYRWAKRGQIIKEASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMTTEPQSLLVDLGSDAIFSCAWTGNPSLTIVWMKRGSGVVLSNEKTLTLKSVRQEDAGKYVCRAVVPRVGAGEREVTLTVNGPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGRYTVETISTEEGVISTLTISNIVRADFQTIYNCTAWNSFGSDTEIIRLKEQGSEMKSGAGLEAESVPMAVIIGVAVGAGVAFLVLMATIVAFCCARSQRNLKGVVSAKNDIRVEIVHKEPASGREGEEHSTIKQLMMDRGEFQQDSVLKQLEVLKEEEKEFQNLKDPTNGYYSVNTFKEHHSTPTISLSSCQPDLRPAGKQRVPTGMSFTNIYSTLSGQGRLYDYGQRFVLGMGSSSIELCEREFQRGSLSDSSSFLDTQCDSSVSSSGKQDGYVQFDKASKASASSSHHSQSSSQNSDPSRPLQRRMQTHV
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving KIRREL3 and CDH15 is found in a patient with severe intellectual disability and dysmorphic facial features. Translocation t(11;16)(q24.2;q24). {ECO:0000269|PubMed:19012874}.
uniprot
proteins
function
FUNCTION: Synaptic adhesion molecule required for the formation of target-specific synapses. Required for formation of target-specific synapses at hippocampal mossy fiber synapses. Required for formation of mossy fiber filopodia, the synaptic structures connecting dentate granule and GABA neurons. Probably acts as a homophilic adhesion molecule that promotes trans-cellular interactions and stabilize mossy fiber filipodia contact and subsequent synapse formation. Required for the coalescence of vomeronasal sensory neuron axons. May be involved in the hematopoietic supportive capacity of stroma cells; the secreted extracellular domain is directly responsible for supporting hematopoietic stem cells. {ECO:0000250|UniProtKB:Q8BR86}.
uniprot
proteins
mass_dalton
85255
uniprot
proteins
post_translational_modification
PTM: Undergoes proteolysis by a metalloprotease and gives rise to a soluble form. {ECO:0000250|UniProtKB:Q8BR86}.
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
11347906
uniprot
proteins
pubmed
12424224
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19012874
uniprot
proteins
pubmed
25488023
uniprot
proteins
pubmed
25902260
uniprot
proteins
sequence_length
778
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19012874}; Single-pass type I membrane protein {ECO:0000269|PubMed:19012874}.; SUBCELLULAR LOCATION: [Processed kin of IRRE-like protein 3]: Secreted {ECO:0000250|UniProtKB:Q8BR86}.
uniprot
proteins
transmembrane_region
TRANSMEM 536..556; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins