ANGPT2
entrez
285
canonical
uniprot
O15123
canonical
ensembl
ENSG00000091879
resolver
ensp
ENSP00000314897
resolver
ensp
ENSP00000343517
resolver
ensp
ENSP00000486858
resolver
ensp
ENSP00000567328
resolver
genesymbol
ANGPT2
resolver
hgnc
HGNC:485
resolver
uniprot
A0AV38
resolver
uniprot
A8K205
resolver
uniprot
B7ZLM7
resolver
uniprot
Q9NRR7
resolver
uniprot
Q9P2Y7
resolver
uniprot_entry
ANGP2_HUMAN
resolver
uniprot_sec
A0AV38
resolver
uniprot_sec
A8K205
resolver
uniprot_sec
B7ZLM7
resolver
uniprot_sec
Q9NRR7
resolver
uniprot_sec
Q9P2Y7
resolver
amino_acid_sequence
MWQIVFFTLSCDLVLAAAYNNFRKSMDSIGKKQYQVQHGSCSYTFLLPEMDNCRSSSSPYVSNAVQRDAPLEYDDSVQRLQVLENIMENNTQWLMKLENYIQDNMKKEMVEIQQNAVQNQTAVMIEIGTNLLNQTAEQTRKLTDVEAQVLNQTTRLELQLLEHSLSTNKLEKQILDQTSEINKLQDKNSFLEKKVLAMEDKHIIQLQSIKEEKDQLQVLVSKQNSIIEELEKKIVTATVNNSVLQKQQHDLMETVNNLLTMMSTSNSAKDPTVAKEEQISFRDCAEVFKSGHTTNGIYTLTFPNSTEEIKAYCDMEAGGGGWTIIQRREDGSVDFQRTWKEYKVGFGNPSGEYWLGNEFVSQLTNQQRYVLKIHLKDWEGNEAYSLYEHFYLSSEELNYRIHLKGLTGTAGKISSISQPGNDFSTKDGDNDKCICKCSQMLTGGWWFDACGPSNLNGMYYPQRQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF
uniprot
proteins
disease_involvement
DISEASE: Lymphatic malformation 10 (LMPHM10) [MIM:619369]: A form of primary lymphedema, a disease characterized by swelling of body parts due to developmental anomalies and functional defects of the lymphatic system. Patients with lymphedema may suffer from recurrent local infections. LMPHM10 is an autosomal dominant form characterized by the onset of swelling in the lower extremities within the first year of life. Lymphedema may also occur in the neck, upper extremities, and scrotum or labia majora. Gradual resorption generally occurs, although some patients may experience progression complicated by cellulitis. Incomplete penetrance has been observed in some families. {ECO:0000269|PubMed:32908006}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896). Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1 (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896). In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (PubMed:15284220, PubMed:19116766, PubMed:19223473, PubMed:9204896). Involved in the regulation of lymphangiogenesis (PubMed:32908006). {ECO:0000269|PubMed:15284220, ECO:0000269|PubMed:19116766, ECO:0000269|PubMed:19223473, ECO:0000269|PubMed:32908006, ECO:0000269|PubMed:9204896}.
uniprot
proteins
mass_dalton
56919
uniprot
proteins
pubmed
10766762
uniprot
proteins
pubmed
12427764
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15284220
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15893672
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
16732286
uniprot
proteins
pubmed
19116766
uniprot
proteins
pubmed
19223473
uniprot
proteins
pubmed
19234476
uniprot
proteins
pubmed
29323190
uniprot
proteins
pubmed
32908006
uniprot
proteins
pubmed
9204896
uniprot
proteins
pubmed
9927494
uniprot
proteins
sequence_length
496
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:32908006}.
uniprot
proteins