Pgk1
entrez
24644
canonical
uniprot
P16617
canonical
ensembl
ENSRNOG00000058249
resolver
ensp
ENSRNOP00000073614
resolver
enst
ENSRNOT00000085653
resolver
genesymbol
Pgk1
resolver
genesymbol_syn
Pgk-1
resolver
uniprot
Q5M945
resolver
uniprot
Q6P508
resolver
uniprot_entry
PGK1_RAT
resolver
uniprot_sec
Q5M945
resolver
uniprot_sec
Q6P508
resolver
amino_acid_sequence
MSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAAELKSLLGKDVLFLKDCVGSEVENACANPAAGTVILLENLRFHVEEEGKGKDASGNKVKAEPAKIDAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTSLYDEEGAKIVKDLMAKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGTESSKKYAEAVARAKQIVWNGPVGVFEWEAFARGTKSLMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEGKVLPGVDALSNV
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
ec_number
2.7.2.3
uniprot
proteins
function
FUNCTION: Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). Acts as a protein kinase when localized to the mitochondrion where it phosphorylates pyruvate dehydrogenase kinase PDK1 to inhibit pyruvate dehydrogenase complex activity and suppress the formation of acetyl-coenzyme A from pyruvate, and consequently inhibit oxidative phosphorylation and promote glycolysis. May play a role in sperm motility. {ECO:0000250|UniProtKB:P00558}.
uniprot
proteins
mass_dalton
44538
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. {ECO:0000250|UniProtKB:P00558}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-203 by MAPK1/ERK2 under hypoxic conditions, which promotes its mitochondrial targeting. {ECO:0000250|UniProtKB:P00558}.
uniprot
proteins
protein_family
Phosphoglycerate kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2610697
uniprot
proteins
sequence_length
417
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P00558}. Mitochondrion matrix {ECO:0000250|UniProtKB:P00558}. Note=Hypoxic conditions promote mitochondrial targeting. Targeted to the mitochondrion following phosphorylation by MAPK1/ERK2, cis-trans isomerization by PIN1, and binding to mitochondrial circRNA mcPGK1. {ECO:0000250|UniProtKB:P00558}.
uniprot
proteins