Ggt5
entrez
29566
canonical
uniprot
Q9QWE9
canonical
ensembl
ENSRNOG00000062276
resolver
ensembl
ENSRNOG00055021257
resolver
ensembl
ENSRNOG00060017767
resolver
ensembl
ENSRNOG00065026665
resolver
ensp
ENSRNOP00000076334
resolver
ensp
ENSRNOP00055029505
resolver
ensp
ENSRNOP00060024565
resolver
ensp
ENSRNOP00065037769
resolver
enst
ENSRNOT00000093720
resolver
enst
ENSRNOT00055036313
resolver
enst
ENSRNOT00060030408
resolver
enst
ENSRNOT00065046033
resolver
genesymbol
Ggt5
resolver
genesymbol_syn
Ggtla1
resolver
uniprot
Q5PQV0
resolver
uniprot_entry
GGT5_RAT
resolver
uniprot_sec
Q5PQV0
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by serine-borate. {ECO:0000250|UniProtKB:P36269}.
uniprot
proteins
amino_acid_sequence
MAWGHRTTVCLVLLGVSLGLAIIVLAVVLPHHQASCRPDAFTRAAVAADSKICSDIGRVILQQQGSPVDAAIAALICTGVVNPQSMGLGGGVVFTIYNASTGKVEVINARETVPASHDQRLLDQCTNALPLCTGAQWIGVPGELRGYAEAHRRYGRLPWAQLFQPTIALLREGFRVPPILSQFLNTSFLQPCLNSSTLRQLFFNGTETLRSQDPLPWPALANTLETVAKEGAEVLYTGKLGQTLVEDIAWQGSQLTVQDLAAFRPKVVEPLEMALGNYTLYSPPPPAGGAILSFILNVLKGFNFSAETVAGPEGKVNMYHHLVEALKFAVGQRWRLWDPYSHPGIQNISQDLLRETLAQHIRQQIDGRGDHQLSHYNLSGVRGNSMGTSHVSVLGEDGSAVAATSTINTPFGAMVYSPRTGILLNNELLDLCWRHKPGSTVTPPPVPGEQPPSSMVPSILINEVQGSKLVIGGAGGELIISAVTQAIVNKLWLGFSLTDAIAAPILHVNSKGHVEYEPKFNQEVRKGLQDRGQSQSQSQRPVFLNSVQAVFQEGPCVYAASDLRKAGKASGY
uniprot
proteins
ec_number
2.3.2.2
uniprot
proteins
ec_number
3.4.19.13
uniprot
proteins
ec_number
3.4.19.14
uniprot
proteins
function
FUNCTION: Cleaves the gamma-glutamyl bond of extracellular glutathione tripeptide (gamma-Glu-Cys-Gly) and certain glutathione conjugates (By similarity). Hydrolyzes glutathione releasing L-Glu and Cys-Gly dipeptide which is further metabolized to maintain extracellular cysteine levels but also to provide cysteine necessary for intracellular glutathione synthesis (By similarity). Among glutathione-S-conjugates metabolizes leukotriene C4 (LTC4) and S-geranylgeranyl-glutathione (GGG), but is inactive toward gamma-glutamyl leucine. Converts extracellular LTC4 to LTD4 during acute inflammatory response. Acts as a negative regulator of GGG bioactivity. GGT5 (via GGG catabolism) and ABCC1 (via extracellular transport) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to bone marrow parenchyma (By similarity). The transpeptidation reaction, i.e. the transfer of gamma-glutamyl moiety to an acceptor molecule to yield a new gamma-glutamyl compound requires high concentration of dipeptide acceptor and is considered nonphysiological (By similarity). {ECO:0000250|UniProtKB:P36269, ECO:0000250|UniProtKB:Q9Z2A9}.
uniprot
proteins
mass_dalton
61569
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; leukotriene D4 biosynthesis. {ECO:0000250|UniProtKB:Q9Z2A9}.; PATHWAY: Sulfur metabolism; glutathione metabolism. {ECO:0000250|UniProtKB:P36269}.
uniprot
proteins
post_translational_modification
PTM: Cleaved by autocatalysis into a large and a small subunit. {ECO:0000250|UniProtKB:P19440}.; PTM: Glycosylated. {ECO:0000250|UniProtKB:Q9Z2A9}.
uniprot
proteins
protein_family
Gamma-glutamyltransferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9374738
uniprot
proteins
sequence_length
572
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9Z2A9}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9Z2A9}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..29; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000250|UniProtKB:Q9Z2A9
uniprot
proteins