Hpgd
entrez
79242
canonical
uniprot
O08699
canonical
ensembl
ENSRNOG00000010610
resolver
ensembl
ENSRNOG00055007748
resolver
ensembl
ENSRNOG00060007105
resolver
ensembl
ENSRNOG00065004274
resolver
ensp
ENSRNOP00000014229
resolver
ensp
ENSRNOP00055010353
resolver
ensp
ENSRNOP00060008781
resolver
ensp
ENSRNOP00065004436
resolver
enst
ENSRNOT00000014229
resolver
enst
ENSRNOT00055012970
resolver
enst
ENSRNOT00060011671
resolver
enst
ENSRNOT00065006230
resolver
genesymbol
Hpgd
resolver
genesymbol_syn
Pgdh1
resolver
uniprot
Q6P687
resolver
uniprot_entry
PGDH_RAT
resolver
uniprot_sec
Q6P687
resolver
amino_acid_sequence
MHVNGKVALVTGAAQGIGKAFTEALLLHGAKVALVDWNLETGVKCKAALDEQFEPQKTLFIQCDVADQKQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEQTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINISSIAGLMPVAQQPVYCASKHGIIGFTRSAAMAANLMKSGVRLNVICPGFVKTPILESIEKEENMGQYIEYTDQIKAMMKFYGILDPSAIANGLINLIEDDALNGAIMKITASKGIHFQDYDLFPSFSKAP
uniprot
proteins
ec_number
1.1.1.-
uniprot
proteins
ec_number
1.1.1.141
uniprot
proteins
ec_number
1.1.1.232
uniprot
proteins
function
FUNCTION: Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites (By similarity) (PubMed:9099857). Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation (By similarity). {ECO:0000250|UniProtKB:P15428, ECO:0000269|PubMed:9099857}.
uniprot
proteins
mass_dalton
28939
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9099857
uniprot
proteins
sequence_length
266
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins