Rapgef4
entrez
56508
canonical
uniprot
Q9EQZ6
canonical
ensembl
ENSMUSG00000049044
resolver
ensp
ENSMUSP00000028525
resolver
ensp
ENSMUSP00000088336
resolver
ensp
ENSMUSP00000099759
resolver
enst
ENSMUST00000028525
resolver
genesymbol
Rapgef4
resolver
genesymbol_syn
Cgef2
resolver
genesymbol_syn
Epac2
resolver
genesymbol_syn
cAMP-GEFII
resolver
genesymbol_syn
mKIAA4040
resolver
uniprot
A2ASW4
resolver
uniprot
A2ASW8
resolver
uniprot
C0ST12
resolver
uniprot
Q571A8
resolver
uniprot
Q8VIP9
resolver
uniprot
Q9CS95
resolver
uniprot
Q9CW52
resolver
uniprot
Q9Z1P0
resolver
uniprot_entry
A2ASW4_MOUSE
resolver
uniprot_entry
A2ASW8_MOUSE
resolver
uniprot_entry
C0ST12_MOUSE
resolver
uniprot_entry
Q571A8_MOUSE
resolver
uniprot_entry
Q9CS95_MOUSE
resolver
uniprot_entry
RPGF4_MOUSE
resolver
uniprot_sec
Q8VIP9
resolver
uniprot_sec
Q9CW52
resolver
uniprot_sec
Q9Z1P0
resolver
amino_acid_sequence
MVAAHAAHSQSSAEWIACLDKRPLERSSEDVDIIFTRLKGVKAFEKFHPNLLRQICLCGYYENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDNTPRHATIVTRESSELLRIEQEDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENTPLIEPHVPLRPAHTITKVPSEKILRAGKILRIAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMIQQTSCVHSRTQAVGMWQVLLEDGVLNHVDQERHFQDKYLFYRFLDDEREDAPLPTEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYDELLHIKALSHLSTTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDDFGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKVPAGNRAANQGNSQPQQKYTVMSGTPEKILEHFLETIRLEPSLNEATDSVLNDFVMMHCVFMPNTQLCPALVAHYHAQPSQGTEQERMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVAMAFLEEFYVSVSDDARMMAAFKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQKRQPIRGSDEVLFKVYCIDHTYTTIRVPVAASVKEVISAVADKLGSGEGLIIVKMNSGGEKVVLKSNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTTGTVGTFELMSSKDLAYQMTTYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEVCLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTAAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTARTVRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP
uniprot
proteins
function
FUNCTION: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Does not seem to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2. {ECO:0000269|PubMed:11056535}.
uniprot
proteins
mass_dalton
115491
uniprot
proteins
mutagenesis
MUTAGEN 467; /note="L->A: Less than 10% of the wild-type maximal activity."; /evidence="ECO:0000269|PubMed:18660803"; MUTAGEN 498; /note="Y->F: 2-fold reduction in maximal activity."; /evidence="ECO:0000269|PubMed:18660803"; MUTAGEN 569; /note="Y->A: 2-fold reduction in maximal activity."; /evidence="ECO:0000269|PubMed:18660803"; MUTAGEN 569; /note="Y->F: 2-fold reduction in maximal activity."; /evidence="ECO:0000269|PubMed:18660803
uniprot
proteins
pubmed
11056535
uniprot
proteins
pubmed
11707077
uniprot
proteins
pubmed
12469113
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18660803
uniprot
proteins
sequence_length
1011
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
uniprot
proteins