Ephx1
entrez
13849
canonical
uniprot
Q9D379
canonical
ensembl
ENSMUSG00000038776
resolver
ensp
ENSMUSP00000047551
resolver
ensp
ENSMUSP00000106697
resolver
enst
ENSMUST00000036928
resolver
enst
ENSMUST00000111068
resolver
genesymbol
Ephx1
resolver
uniprot
E9PWK1
resolver
uniprot
P97869
resolver
uniprot_entry
E9PWK1_MOUSE
resolver
uniprot_entry
HYEP_MOUSE
resolver
uniprot_sec
P97869
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by 10-hydroxystearamide and methoxy-arachidonyl fluorophosphate. {ECO:0000250|UniProtKB:P07099}.
uniprot
proteins
amino_acid_sequence
MWLELILASVLGFVIYWFVSRDKEETLPLEDGWWGPGSKPSAKEDESIRPFKVETSDEEIKDLHQRIDRFRASPPLEGSRFHYGFNSSYLKKVVSFWRNEFDWRKQVEILNQYPHFKTKIEGLDIHFIHVKPPQLPSGRTPKPLLMVHGWPGSFYEFYKIIPLLTDPKTHGLSDEHVFEVICPSIPGYGFSEASSKKGLNSVATARIFYKLMSRLGFQKFYIQGGDWGSLICTNIAQMVPNHVKGLHLNMSFISRNIYSLTPLLGQRFGRFLGYTEKDLELLYPFKEKVFYNIMRESGYLHIQATKPDTVGCALNDSPVGLAAYILEKFSTWTKSEYRELEDGGLERKFSLEDLLTNIMIYWTTGTIVSSQRFYKENLGQGVMVHRHEGMKVFVPTGYSAFPSEILHAPEKWVKVKYPKLISYSYMERGGHFAAFEEPKLLAQDIRKFVSLAELQ
uniprot
proteins
ec_number
3.3.2.9
uniprot
proteins
function
FUNCTION: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol (By similarity). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (PubMed:34799735). {ECO:0000250|UniProtKB:P07099, ECO:0000250|UniProtKB:P07687, ECO:0000269|PubMed:34799735}.
uniprot
proteins
mass_dalton
52577
uniprot
proteins
protein_family
Peptidase S33 family
uniprot
proteins
pubmed
11003708
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
34799735
uniprot
proteins
sequence_length
455
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000250|UniProtKB:P07687}; Single-pass type III membrane protein {ECO:0000250|UniProtKB:P07687}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P07687}; Single-pass type III membrane protein {ECO:0000250|UniProtKB:P07687}.
uniprot
proteins
transmembrane_region
TRANSMEM 1..21; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins