STAT5A
entrez
6776
canonical
uniprot
P42229
canonical
ensembl
ENSG00000126561
resolver
ensp
ENSP00000341208
resolver
ensp
ENSP00000443107
resolver
ensp
ENSP00000465437
resolver
ensp
ENSP00000468749
resolver
ensp
ENSP00000503484
resolver
ensp
ENSP00000616411
resolver
ensp
ENSP00000722581
resolver
enst
ENST00000588868
resolver
enst
ENST00000676631
resolver
genesymbol
STAT5A
resolver
genesymbol_syn
STAT5
resolver
hgnc
HGNC:11366
resolver
uniprot
A0A384N5W4
resolver
uniprot
A0A7I2YQF1
resolver
uniprot
A8K6I5
resolver
uniprot
K7EK35
resolver
uniprot
Q1KLZ6
resolver
uniprot
Q59GY7
resolver
uniprot_entry
A0A384N5W4_HUMAN
resolver
uniprot_entry
A0A7I2YQF1_HUMAN
resolver
uniprot_entry
A8K6I5_HUMAN
resolver
uniprot_entry
K7EK35_HUMAN
resolver
uniprot_entry
Q59GY7_HUMAN
resolver
uniprot_entry
STA5A_HUMAN
resolver
uniprot_sec
Q1KLZ6
resolver
amino_acid_sequence
MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLVREANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRLGDLSYLIYVFPDRPKDEVFSKYYTPVLAKAVDGYVKPQIKQVVPEFVNASADAGGSSATYMDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSLDSRLSPPAGLFTSARGSLS
uniprot
proteins
function
FUNCTION: Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation. {ECO:0000269|PubMed:15534001}.
uniprot
proteins
mass_dalton
90647
uniprot
proteins
post_translational_modification
PTM: Tyrosine phosphorylated in response to KITLG/SCF, IL2, IL3, IL7, IL15, CSF2/GMCSF, GH1, PRL, EPO and THPO (By similarity). Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus (PubMed:21135090). Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Tyrosine phosphorylation is required for DNA-binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity (By similarity). Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3 (PubMed:14504097). Alternatively, can be phosphorylated by JAK2 at Tyr-694 (PubMed:12529425). {ECO:0000250|UniProtKB:P40763, ECO:0000250|UniProtKB:P42230, ECO:0000250|UniProtKB:Q62771, ECO:0000269|PubMed:12529425, ECO:0000269|PubMed:14504097, ECO:0000269|PubMed:21135090}.; PTM: ISGylated. {ECO:0000250|UniProtKB:P42230}.
uniprot
proteins
protein_family
Transcription factor STAT family
uniprot
proteins
pubmed
11773439
uniprot
proteins
pubmed
12529425
uniprot
proteins
pubmed
12954634
uniprot
proteins
pubmed
14504097
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15526160
uniprot
proteins
pubmed
15534001
uniprot
proteins
pubmed
15677474
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21135090
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24319783
uniprot
proteins
pubmed
35939714
uniprot
proteins
pubmed
7719937
uniprot
proteins
sequence_length
794
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15534001}. Nucleus {ECO:0000269|PubMed:15534001}. Note=Translocated into the nucleus in response to phosphorylation.
uniprot
proteins