Q9CVN6
uniprot
Q9CVN6
canonical
amino_acid_sequence
MADSKMKWGQAWDSSLGTATTSSSSATGSPSPFQNIRVPDTRAPRVAHTTFTLEAFECLAASQAGRLWKQVRQFWVDHFSRRFSPRRPPLRHISSMSTFYLLDHRTRQAELGLNYGEPRTRLSDEAFVFRGGRWTPEGKRASARTPLPSSTIPAWKPQVQPIKSQVLLEENNYLKLQQELLMDMLTETTARMQLLEKKVDADNNPAAPARSWKRKMPKQRGAGVLIIQPRALESR
uniprot
proteins
function
FUNCTION: Plays a key role in the correct positioning of the annulus, a septin-based ring strucure in the sperm flagellum, serving both as a physical barrier and a membrane diffusion barrier that separates the midpiece (MP) from the principal piece (PP) (PubMed:38197861). This positioning is essential for proper sperm motility and function (PubMed:38197861). Interacts with CIBAR1 to form a complex which localizes to the curved membrane region of the flagellar pocket (PubMed:38197861). By doing so, may provide stability and rigidity to the periannular membrane to prevent membrane deformation (PubMed:38197861). This function is crucial for halting annulus migration at the proximal end of the fibrous sheath-containing PP (PubMed:38197861). {ECO:0000269|PubMed:38197861}.
uniprot
proteins
mass_dalton
26690
uniprot
proteins
protein_family
Chibby family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
38197861
uniprot
proteins
sequence_length
235
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000269|PubMed:38197861}. Note=Localizes to the annulus at the junction between the midpiece (MP) and principal piece (PP) of the sperm flagellum. {ECO:0000269|PubMed:38197861}.
uniprot
proteins