Smad9
entrez
85435
canonical
uniprot
O54835
canonical
ensembl
ENSRNOG00000000091
resolver
ensp
ENSRNOP00000000102
resolver
enst
ENSRNOT00000000102
resolver
genesymbol
Smad9
resolver
genesymbol_syn
Madh8
resolver
genesymbol_syn
Madh9
resolver
genesymbol_syn
Smad8
resolver
uniprot
G3V603
resolver
uniprot_entry
G3V603_RAT
resolver
uniprot_entry
SMAD9_RAT
resolver
amino_acid_sequence
MHPSTPISSLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDSLVKKLKKKKGAMDELERALSCPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLECCEFPFGSKQKEVCINPYHYRRVETPVLPPVLVPRHSEYNPQLSLLAKFRSASLHSEPLMPHNATYPDSFQQSLGPAPPSSPGHVFPQSPCPTSYPQSPGSPSESDSPYQHSDFRPVCYEEPLHWCSVAYYELNNRVGETFQASSRSVLIDGFTDPSNNRNRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECVSDSSIFVQSRNCNYQHGFHPATVCKIPSGCSLKVFNNQLFAQLLAQLLAQSVHHGFEVVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPHNPISSVS
uniprot
proteins
function
FUNCTION: Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD) (By similarity). Has been shown to be activated by activin type I receptor-like kinase-2 (ALK-2) which stimulates heteromerization between SMAD9 and SMAD4. ALK-2 binds TGF-beta, activin and BMP. {ECO:0000250}.
uniprot
proteins
mass_dalton
48992
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase (By similarity). Phosphorylated by activin type I receptor-like kinase-2 (ALK-2). {ECO:0000250}.
uniprot
proteins
protein_family
Dwarfin/SMAD family
uniprot
proteins
pubmed
9371779
uniprot
proteins
sequence_length
434
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4 (By similarity). {ECO:0000250}.
uniprot
proteins