FBXO41
entrez
150726
canonical
uniprot
Q8TF61
canonical
ensembl
ENSG00000163013
resolver
ensp
ENSP00000295133
resolver
ensp
ENSP00000428646
resolver
ensp
ENSP00000430968
resolver
enst
ENST00000295133
resolver
enst
ENST00000520530
resolver
enst
ENST00000521871
resolver
genesymbol
FBXO41
resolver
genesymbol_syn
FBX41
resolver
genesymbol_syn
KIAA1940
resolver
hgnc
HGNC:29409
resolver
uniprot
G3V0Z7
resolver
uniprot
Q2M1V8
resolver
uniprot_entry
FBX41_HUMAN
resolver
uniprot_sec
G3V0Z7
resolver
uniprot_sec
Q2M1V8
resolver
amino_acid_sequence
MASLDLPYRCPRCGEHKRFRSLSSLRAHLEYSHTYETLYILSKTNSICDGAAAAAAAAAAASGFPLAPEPAALLAVPGARREVFESTSFQGKEQAAGPSPAAPHLLHHHHHHAPLAHFPGDLVPASLPCEELAEPGLVPAAAARYALREIEIPLGELFARKSVASSACSTPPPGPGPGPCPGPASASPASPSPADVAYEEGLARLKIRALEKLEVDRRLERLSEEVEQKIAGQVGRLQAELERKAAELETARQESARLGREKEELEERASELSRQVDVSVELLASLKQDLVHKEQELSRKQQEVVQIDQFLKETAAREASAKLRLQQFIEELLERADRAERQLQVISSSCGSTPSASLGRGGGGGGAGPNARGPGRMREHHVGPAVPNTYAVSRHGSSPSTGASSRVPAASQSSGCYDSDSLELPRPEEGAPEDSGPGGLGTRAQAANGGSERSQPPRSSGLRRQAIQNWQRRPRRHSTEGEEGDVSDVGSRTTESEAEGPLDAPRPGPAMAGPLSSCRLSARPEGGSGRGRRAERVSPSRSNEVISPEILKMRAALFCIFTYLDTRTLLHAAEVCRDWRFVARHPAVWTRVLLENARVCSKFLAMLAQWCTQAHSLTLQNLKPRQRGKKESKEEYARSTRGCLEAGLESLLKAAGGNLLILRISHCPNILTDRSLWLASCYCRALQAVTYRSATDPVGHEVIWALGAGCREIVSLQVAPLHPCQQPTRFSNRCLQMIGRCWPHLRALGVGGAGCGVQGLASLARNCMRLQVLELDHVSEITQEVAAEVCREGLKGLEMLVLTATPVTPKALLHFNSICRNLKSIVVQIGIADYFKEPSSPEAQKLFEDMVTKLQALRRRPGFSKILHIKVEGGC
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. Required in the developing brain for neuronal migration and long-term cerebellar integrity. Regulates postnatal hippocampal development, synaptic vesicle release probability at excitatory synapses and readily releasable pool size at inhibitory synapses. Upon accumulation at the centriole, promotes disassembly of primary cilia and negatively regulates Sonic hedgehog signaling. {ECO:0000250|UniProtKB:Q6NS60}.
uniprot
proteins
mass_dalton
94496
uniprot
proteins
pubmed
11853319
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
sequence_length
875
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6NS60}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q6NS60}. Note=Centriolar targeting requires both the coiled-coil and F-box domains. {ECO:0000250|UniProtKB:Q6NS60}.
uniprot
proteins