AREL1
entrez
9870
canonical
uniprot
O15033
canonical
ensembl
ENSG00000119682
resolver
ensp
ENSP00000348714
resolver
ensp
ENSP00000450557
resolver
ensp
ENSP00000452101
resolver
ensp
ENSP00000504887
resolver
ensp
ENSP00000550405
resolver
ensp
ENSP00000550406
resolver
ensp
ENSP00000589403
resolver
enst
ENST00000681099
resolver
enst
ENST00000919344
resolver
genesymbol
AREL1
resolver
genesymbol_syn
KIAA0317
resolver
hgnc
HGNC:20363
resolver
uniprot
A0A7P0T811
resolver
uniprot
B4E2C7
resolver
uniprot
Q7LDY1
resolver
uniprot
Q8IYY9
resolver
uniprot_entry
A0A7P0T811_HUMAN
resolver
uniprot_entry
AREL1_HUMAN
resolver
uniprot_sec
B4E2C7
resolver
uniprot_sec
Q7LDY1
resolver
uniprot_sec
Q8IYY9
resolver
amino_acid_sequence
MFYVIGGITVSVVAFFFTIKFLFELAARVVSFLQNEDRERRGDRTIYDYVRGNYLDPRSCKVSWDWKDPYEVGHSMAFRVHLFYKNGQPFPAHRPVGLRVHISHVELAVEIPVTQEVLQEPNSNVVKVAFTVRKAGRYEITVKLGGLNVAYSPYYKIFQPGMVVPSKTKIVCHFSTLVLTCGQPHTLQIVPRDEYDNPTNNSMSLRDEHNYTLSIHELGPQEEESTGVSFEKSVTSNRQTFQVFLRLTLHSRGCFHACISYQNQPINNGEFDIIVLSEDEKNIVERNVSTSGVSIYFEAYLYNATNCSSTPWHLPPMHMTSSQRRPSTAVDEEDEDSPSECHTPEKVKKPKKVYCYVSPKQFSVKEFYLKIIPWRLYTFRVCPGTKFSYLGPDPVHKLLTLVVDDGIQPPVELSCKERNILAATFIRSLHKNIGGSETFQDKVNFFQRELRQVHMKRPHSKVTLKVSRHALLESSLKATRNFSISDWSKNFEVVFQDEEALDWGGPRREWFELICKALFDTTNQLFTRFSDNNQALVHPNPNRPAHLRLKMYEFAGRLVGKCLYESSLGGAYKQLVRARFTRSFLAQIIGLRMHYKYFETDDPEFYKSKVCFILNNDMSEMELVFAEEKYNKSGQLDKVVELMTGGAQTPVTNANKIFYLNLLAQYRLASQVKEEVEHFLKGLNELVPENLLAIFDENELELLMCGTGDISVSDFKAHAVVVGGSWHFREKVMRWFWTVVSSLTQEELARLLQFTTGSSQLPPGGFAALCPSFQIIAAPTHSTLPTAHTCFNQLCLPTYDSYEEVHRMLQLAISEGCEGFGML
uniprot
proteins
ec_number
2.3.2.26
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that catalyzes 'Lys-11'- or 'Lys-33'-linked polyubiquitin chains, with some preference for 'Lys-33' linkages (PubMed:25752577). E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:23479728, PubMed:31578312). Ubiquitinates SEPTIN4, DIABLO/SMAC and HTRA2 in vitro (PubMed:23479728). Modulates pulmonary inflammation by targeting SOCS2 for ubiquitination and subsequent degradation by the proteasome (PubMed:31578312). {ECO:0000269|PubMed:23479728, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:31578312}.
uniprot
proteins
mass_dalton
94223
uniprot
proteins
mutagenesis
MUTAGEN 790; /note="C->A: Failure to form ubiquitin thioester complex."; /evidence="ECO:0000269|PubMed:23479728
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:23479728, ECO:0000269|PubMed:25752577}.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated in vitro in the presence of E2 enzyme UBE2D1/UBCH5A. {ECO:0000269|PubMed:23479728}.
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23479728
uniprot
proteins
pubmed
25752577
uniprot
proteins
pubmed
31578312
uniprot
proteins
pubmed
9205841
uniprot
proteins
sequence_length
823
uniprot
proteins