Hdac8
entrez
363481
canonical
uniprot
B1WC68
canonical
ensembl
ENSRNOG00000003122
resolver
ensembl
ENSRNOG00055030327
resolver
ensembl
ENSRNOG00060025503
resolver
ensembl
ENSRNOG00065016757
resolver
ensp
ENSRNOP00000004224
resolver
ensp
ENSRNOP00055043510
resolver
ensp
ENSRNOP00060036691
resolver
ensp
ENSRNOP00065022087
resolver
enst
ENSRNOT00000004224
resolver
enst
ENSRNOT00055052640
resolver
enst
ENSRNOT00060044247
resolver
enst
ENSRNOT00065027969
resolver
genesymbol
Hdac8
resolver
uniprot_entry
HDAC8_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Its activity is inhibited by trichostatin A (TSA) and butyrate, 2 well known histone deacetylase inhibitors. {ECO:0000250|UniProtKB:Q9BY41}.
uniprot
proteins
amino_acid_sequence
MEIPEEPANSGHSLPPVYIYSPEYVSICDSLVKVPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDEDHPDSIEYGLGYDCPATEGIFDYAAAIGGGTITAAQCLIDGKCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFDRILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDMSDVGLGKGRYYSVNVPIQDGIQDEKYYHICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYVLQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
uniprot
proteins
ec_number
3.5.1.-
uniprot
proteins
ec_number
3.5.1.98
uniprot
proteins
function
FUNCTION: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones. {ECO:0000250|UniProtKB:Q9BY41}.
uniprot
proteins
mass_dalton
41754
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKA on serine 39. Phosphorylation reduces deacetylase activity observed preferentially on histones H3 and H4 (By similarity). {ECO:0000250|UniProtKB:Q9BY41}.
uniprot
proteins
protein_family
HD type 1 subfamily
uniprot
proteins
protein_family
Histone deacetylase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
377
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BY41}. Chromosome {ECO:0000250|UniProtKB:Q9BY41}. Cytoplasm {ECO:0000250|UniProtKB:Q9BY41}. Note=Excluded from the nucleoli. Found in the cytoplasm of cells showing smooth muscle differentiation. {ECO:0000250|UniProtKB:Q9BY41}.
uniprot
proteins