Mlf1
entrez
17349
canonical
uniprot
Q9QWV4
canonical
ensembl
ENSMUSG00000048416
resolver
ensp
ENSMUSP00000058596
resolver
ensp
ENSMUSP00000077072
resolver
enst
ENSMUST00000061322
resolver
enst
ENSMUST00000077916
resolver
genesymbol
Mlf1
resolver
genesymbol_syn
Hls7
resolver
uniprot
F6RKX9
resolver
uniprot
O70217
resolver
uniprot
Q3V042
resolver
uniprot
Q8JZS2
resolver
uniprot_entry
F6RKX9_MOUSE
resolver
uniprot_entry
MLF1_MOUSE
resolver
uniprot_entry
Q3V042_MOUSE
resolver
uniprot_entry
Q8JZS2_MOUSE
resolver
uniprot_sec
O70217
resolver
amino_acid_sequence
MFRMLSSSFEDDPFFADSFLAHRESMRNMMRSFSEPLGRDLLSISDGRGRTHNRRERDDGEDSLTHADVNPFQTMDRMMANMRSGIQELQRNFGQLSMDPNGHSFCSSSVMTYSKVGDEPPKVFQASTQTRRAPGGVKETRKAMRDSDSGLERMAVGHHIHDRGHVIRKSKNNKTGDEEVNQEFINMNESDAHAFDDEWQNEVLKYKSIGRSGNTGMRSVGHEHPGSRELKRREKIHRNSAIESGRRSNVFVDKLNVKGSPVKITKK
uniprot
proteins
function
FUNCTION: Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. {ECO:0000269|PubMed:10523300, ECO:0000269|PubMed:15122318}.
uniprot
proteins
mass_dalton
30432
uniprot
proteins
mutagenesis
MUTAGEN 34; /note="S->A: 70% reduction in binding to YWHAZ and increased nuclear localization."; /evidence="ECO:0000269|PubMed:17008314"; MUTAGEN 149; /note="S->A: No effect on binding to YWHAZ."; /evidence="ECO:0000269|PubMed:17008314
uniprot
proteins
post_translational_modification
PTM: Phosphorylation is required for binding to YWHAZ. {ECO:0000269|PubMed:12176995}.
uniprot
proteins
protein_family
MLF family
uniprot
proteins
pubmed
10393836
uniprot
proteins
pubmed
10523300
uniprot
proteins
pubmed
12176995
uniprot
proteins
pubmed
15122318
uniprot
proteins
pubmed
17008314
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27914912
uniprot
proteins
sequence_length
267
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10523300}. Nucleus {ECO:0000269|PubMed:10523300}. Cell projection, cilium {ECO:0000269|PubMed:27914912}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:27914912}. Note=Shuttles between the cytoplasm and nucleus. {ECO:0000269|PubMed:17008314}.
uniprot
proteins