Tbx5
entrez
21388
canonical
uniprot
P70326
canonical
ensembl
ENSMUSG00000018263
resolver
ensp
ENSMUSP00000018407
resolver
enst
ENSMUST00000018407
resolver
genesymbol
Tbx5
resolver
uniprot
Q5CZX7
resolver
uniprot
Q9R003
resolver
uniprot_entry
Q5CZX7_MOUSE
resolver
uniprot_entry
TBX5_MOUSE
resolver
uniprot_sec
Q9R003
resolver
amino_acid_sequence
MADTDEGFGLARTPLEPDSKDRSCDSKPESALGAPSKSPSSPQAAFTQQGMEGIKVFLHERELWLKFHEVGTEMIITKAGRRMFPSYKVKVTGLNPKTKYILLMDIVPADDHRYKFADNKWSVTGKAEPAMPGRLYVHPDSPATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNGFGSKNTAFCTHVFPETAFIAVTSYQNHKITQLKIENNPFAKGFRGSDDLELHRMSRMQSKEYPVVPRSTVRHKVTSNHSPFSSETRALSTSSNLGSQYQCENGVSGPSQDLLPPPNPYPLAQEHSQIYHCTKRKDEECSSTEHPYKKPYMETSPSEEDTFYRSGYPQQQGLSTSYRTESAQRQACMYASSAPPSEPVPSLEDISCNTWPSMPSYSSCTVTTVQPMDRLPYQHFSAHFTSGPLVPRLAGMANHGSPQLGEGMFQHQTSVAHQPVVRQCGPQTGLQSPGGLQPPEFLYTHGVPRTLSPHQYHSVHGVGMVPEWSENS
uniprot
proteins
function
FUNCTION: DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation. Binds to the core DNA motif of NPPA promoter. {ECO:0000250|UniProtKB:Q99593}.
uniprot
proteins
mass_dalton
57832
uniprot
proteins
post_translational_modification
PTM: Acetylation at Lys-339 by KAT2A and KAT2B promotes nuclear retention. {ECO:0000250|UniProtKB:Q99593}.
uniprot
proteins
pubmed
10373308
uniprot
proteins
pubmed
8853987
uniprot
proteins
pubmed
8878690
uniprot
proteins
sequence_length
518
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q99593, ECO:0000255|PROSITE-ProRule:PRU00201}. Cytoplasm {ECO:0000250|UniProtKB:Q99593}. Note=Shuttles between the cytoplasm and the nucleus. Acetylation at Lys-339 promotes nuclear retention. {ECO:0000250|UniProtKB:Q99593}.
uniprot
proteins