Slc1a3
entrez
29483
canonical
uniprot
P24942
canonical
ensembl
ENSRNOG00000016163
resolver
ensp
ENSRNOP00000022319
resolver
ensp
ENSRNOP00000036554
resolver
ensp
ENSRNOP00000073634
resolver
ensp
ENSRNOP00000075509
resolver
enst
ENSRNOT00000022319
resolver
enst
ENSRNOT00000035821
resolver
enst
ENSRNOT00000077790
resolver
enst
ENSRNOT00000085599
resolver
genesymbol
Slc1a3
resolver
genesymbol_syn
Eaat1
resolver
uniprot
A0A0G2JSU1
resolver
uniprot
A0A0G2K611
resolver
uniprot
A0A0G2KAS7
resolver
uniprot
G3V846
resolver
uniprot
Q9JK43
resolver
uniprot_entry
A0A0G2JSU1_RAT
resolver
uniprot_entry
A0A0G2K611_RAT
resolver
uniprot_entry
A0A0G2KAS7_RAT
resolver
uniprot_entry
EAA1_RAT
resolver
uniprot_entry
G3V846_RAT
resolver
uniprot_sec
Q9JK43
resolver
amino_acid_sequence
MTKSNGEEPRMGSRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVSAVIVGTILGFALRPYKMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMGMRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMYREGKIVQVTAADAFLDLIRNMFPPNLVEACFKQFKTSYEKRSFKVPIQANETLLGAVINNVSEAMETLTRIREEMVPVPGSVNGVNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPLGILFLIAGKILEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITALGTSSSSATLPITFKCLEENNGVDKRITRFVLPVGATINMDGTALYEALAAIFIAQVNNFDLNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSLGAGIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLIAQDNEPEKPVADSETKM
uniprot
proteins
function
FUNCTION: Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:1279699, PubMed:8387171). Functions as a symporter that transports one amino acid molecule together with two or three Na(+) ions and one proton, in parallel with the counter-transport of one K(+) ion (By similarity). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). {ECO:0000250|UniProtKB:O57321, ECO:0000250|UniProtKB:P56564, ECO:0000269|PubMed:1279699, ECO:0000269|PubMed:8387171}.
uniprot
proteins
mass_dalton
59697
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:8521863}.
uniprot
proteins
protein_family
Dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family
uniprot
proteins
protein_family
SLC1A3 subfamily
uniprot
proteins
pubmed
11086157
uniprot
proteins
pubmed
1279699
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7527019
uniprot
proteins
pubmed
8387171
uniprot
proteins
pubmed
8521863
uniprot
proteins
sequence_length
543
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1279699, ECO:0000269|PubMed:8387171}; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 48..68; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 87..108; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 123..145; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 237..260; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 270..297; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 319..340; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 386..412; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P43003"; TRANSMEM 473..494; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P43003
uniprot
proteins