Gtpbp1
entrez
300077
canonical
uniprot
D2XV59
canonical
ensembl
ENSRNOG00000014634
resolver
ensembl
ENSRNOG00055032535
resolver
ensembl
ENSRNOG00060029992
resolver
ensembl
ENSRNOG00065032958
resolver
ensp
ENSRNOP00000039165
resolver
ensp
ENSRNOP00055046392
resolver
ensp
ENSRNOP00060043411
resolver
ensp
ENSRNOP00065046699
resolver
enst
ENSRNOT00000049247
resolver
enst
ENSRNOT00055056239
resolver
enst
ENSRNOT00060052187
resolver
enst
ENSRNOT00065056720
resolver
genesymbol
Gtpbp1
resolver
uniprot_entry
GTPB1_RAT
resolver
amino_acid_sequence
MAAERSRSPVDSPVPASMFAPEPSSPGAARAAAAAARLHGGFDSDCSEDGEALNGEPELDLTSKLVLVSPTSEQYDSLLRQMWERMDEGCGETIYVIGQGSDGTEYGLSEADMEASYATVKSMAEQIEADVILLRERQESGGRVRDYLVRKRVGDNDFLEVRVAVVGNVDAGKSTLLGVLTHGELDNGRGFARQKLFRHKHEIESGRTSSVGNDILGFDSEGNVVNKPDSHGGSLEWTKICEKSSKVITFIDLAGHEKYLKTTVFGMTGHLPDFCMLMVGSNAGIVGMTKEHLGLALALNVPVFVVVTKIDMCPANILQETLKLLQRLLKSPGCRKIPVLVQSKDDVIVTASNFSSERMCPIFQISNVTGENLDLLKMFLNLLSPRTSYREEEPAEFQIDDTYSVPGVGTVVSGTTLRGLIKLNDTLLLGPDPLGNFLSIAVKSIHRKRMPVKEVRGGQTASFALKKIKRSSIRKGMVMVSPRLNPQASWEFEAEILVLHHPTTISPRYQAMVHCGSIRQTATILSMDKDCLRTGDKATVHFRFIKTPEYLHIDQRLVFREGRTKAVGTITKLLQTTNNSPMNSKPQQIKMQSTKKGPLSKREEGGPSGVPAAGPPSTGDEASSLGTTQAATSSGLQPQPKPSSGGRRRGGQRHKVKSQGACVTPASGC
uniprot
proteins
ec_number
3.6.5.3
uniprot
proteins
function
FUNCTION: GTPase that plays a role in the elongation phase of protein synthesis by forming ternary complexes with GTP and aminoacyl-transfer RNAs (aa-tRNAs), and delivering aa-tRNAs to the ribosomal A site in a GTP-dependent manner. Is also able to deliver deacylated tRNA to the A site. Additionally, it is involved in RNA quality control; after GTP hydrolysis, which is not immediately followed by rapid peptide bond formation, GTPBP1 likely retains aa-tRNA in the A site and promotes exosomal degradation of faulty mRNAs engaged in 80S elongation complexes (By similarity). Plays a role in the regulation of circadian mRNA stability. {ECO:0000250|UniProtKB:O00178, ECO:0000269|PubMed:21515746}.
uniprot
proteins
mass_dalton
72489
uniprot
proteins
mutagenesis
MUTAGEN 173..174; /note="KS->AA: Reduced decay of target mRNA. Slightly reduced GTPase activity. No effect on GTP binding."; /evidence="ECO:0000269|PubMed:21515746"; MUTAGEN 173; /note="K->A: Reduced decay of target mRNA. No effect on GTP binding."; /evidence="ECO:0000269|PubMed:21515746"; MUTAGEN 173; /note="K->E: Reduced decay of target mRNA. Reduced GTPase activity."; /evidence="ECO:0000269|PubMed:21515746
uniprot
proteins
protein_family
Classic translation factor GTPase family
uniprot
proteins
protein_family
GTPBP1 subfamily
uniprot
proteins
protein_family
TRAFAC class translation factor GTPase superfamily
uniprot
proteins
pubmed
21515746
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
669
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21515746}.
uniprot
proteins