SPEF1
entrez
25876
canonical
uniprot
Q9Y4P9
canonical
ensembl
ENSG00000101222
resolver
ensp
ENSP00000369080
resolver
genesymbol
SPEF1
resolver
genesymbol_syn
C20orf28
resolver
hgnc
HGNC:15874
resolver
uniprot
A5YM71
resolver
uniprot
D3DVY0
resolver
uniprot
Q5JX78
resolver
uniprot_entry
SPEF1_HUMAN
resolver
uniprot_sec
A5YM71
resolver
uniprot_sec
D3DVY0
resolver
uniprot_sec
Q5JX78
resolver
amino_acid_sequence
MASSVDEEALHQLYLWVDNIPLSRPKRNLSRDFSDGVLVAEVIKFYFPKMVEMHNYVPANSLQQKLSNWGHLNRKVLKRLNFSVPDDVMRKIAQCAPGVVELVLIPLRQRLEERQRRRKQGAGSLQELAPQDGSGYMDVGVSQKARGEGVPDPQGGGQLSWDRPPAPRPPAYNRALQGDPSFVLQIAEKEQELLASQETVQVLQMKVRRLEHLLQLKNVRIEDLSRRLQQAERKQR
uniprot
proteins
function
FUNCTION: Microtubule-associated protein involved in the stabilization of microtubules along the axis of migration during radial intercalation. Promotes the establishment and stabilization of an axis of microtubules required for the active migration of cells into the outer epithelium (By similarity). Microtubule-associated protein that promotes microtubule bundling and stabilizes microtubules against depolymerization in response to cold shock (By similarity). Essential for ciliary central apparatus formation which requires both its microtubule-binding and bundling activities and for ciliary localization of HYDIN and SPAG6 in ependymal cilia (By similarity). Binds actin in intestinal epithelial cells (IECs), essential for IECs survival and contributes to formation of filopodia and lamellipodia in migrating IECs (PubMed:31473225). Regulates planar cell polarity signaling pathway and asymmetric microtubule accumulation in ciliated epithelia (By similarity). {ECO:0000250|UniProtKB:Q0IH24, ECO:0000250|UniProtKB:Q99JL1, ECO:0000269|PubMed:31473225}.
uniprot
proteins
mass_dalton
26987
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15979255
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
31473225
uniprot
proteins
sequence_length
236
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:31473225}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q99JL1}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q0IH24}. Apical cell membrane {ECO:0000269|PubMed:31473225}. Basolateral cell membrane {ECO:0000269|PubMed:31473225}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:31473225}. Cell projection, microvillus {ECO:0000269|PubMed:31473225}. Cell projection, lamellipodium {ECO:0000269|PubMed:31473225}. Cell projection, filopodium {ECO:0000269|PubMed:31473225}. Note=Present in the tails of developing and epididymal sperm, internal to the fibrous sheath and around the outer dense fibers of the sperm flagellum. Also found at the apical tip of cilia (By similarity). Colocalizes with TJP1 and CGN at sites of cell-cell contact in intestinal epithelial cells (PubMed:31473225). {ECO:0000250|UniProtKB:Q0IH24, ECO:0000269|PubMed:31473225}.
uniprot
proteins