Tyro3
entrez
22174
canonical
uniprot
P55144
canonical
ensembl
ENSMUSG00000027298
resolver
ensp
ENSMUSP00000028763
resolver
ensp
ENSMUSP00000106410
resolver
genesymbol
Tyro3
resolver
genesymbol_syn
Dtk
resolver
genesymbol_syn
Rse
resolver
genesymbol_syn
Tif
resolver
uniprot
O09070
resolver
uniprot
O09080
resolver
uniprot
P70285
resolver
uniprot
Q60752
resolver
uniprot
Q62482
resolver
uniprot
Q62483
resolver
uniprot
Q62484
resolver
uniprot
Q6NZM6
resolver
uniprot
Q78E85
resolver
uniprot
Q78E87
resolver
uniprot_entry
TYRO3_MOUSE
resolver
uniprot_sec
O09070
resolver
uniprot_sec
O09080
resolver
uniprot_sec
P70285
resolver
uniprot_sec
Q60752
resolver
uniprot_sec
Q62482
resolver
uniprot_sec
Q62483
resolver
uniprot_sec
Q62484
resolver
uniprot_sec
Q6NZM6
resolver
uniprot_sec
Q78E85
resolver
uniprot_sec
Q78E87
resolver
amino_acid_sequence
MALRRSMGWPGLRPLLLAGLASLLLPGSAAAGLKLMGAPVKMTVSQGQPVKLNCSVEGMEDPDIHWMKDGTVVQNASQVSISISEHSWIGLLSLKSVERSDAGLYWCQVKDGEETKISQSVWLTVEGVPFFTVEPKDLAVPPNAPFQLSCEAVGPPEPVTIYWWRGLTKVGGPAPSPSVLNVTGVTQRTEFSCEARNIKGLATSRPAIVRLQAPPAAPFNTTVTTISSYNASVAWVPGADGLALLHSCTVQVAHAPGEWEALAVVVPVPPFTCLLRNLAPATNYSLRVRCANALGPSPYGDWVPFQTKGLAPARAPQNFHAIRTDSGLILEWEEVIPEDPGEGPLGPYKLSWVQENGTQDELMVEGTRANLTDWDPQKDLILRVCASNAIGDGPWSQPLVVSSHDHAGRQGPPHSRTSWVPVVLGVLTALITAAALALILLRKRRKETRFGQAFDSVMARGEPAVHFRAARSFNRERPERIEATLDSLGISDELKEKLEDVLIPEQQFTLGRMLGKGEFGSVREAQLKQEDGSFVKVAVKMLKADIIASSDIEEFLREAACMKEFDHPHVAKLVGVSLRSRAKGRLPIPMVILPFMKHGDLHAFLLASRIGENPFNLPLQTLVRFMVDIACGMEYLSSRNFIHRDLAARNCMLAEDMTVCVADFGLSRKIYSGDYYRQGCASKLPVKWLALESLADNLYTVHSDVWAFGVTMWEIMTRGQTPYAGIENAEIYNYLIGGNRLKQPPECMEEVYDLMYQCWSADPKQRPSFTCLRMELENILGHLSVLSTSQDPLYINIERAEQPTESGSPEVHCGERSSSEAGDGSGVGAVGGIPSDSRYIFSPGGLSESPGQLEQQPESPLNENQRLLLLQQGLLPHSSC
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. {ECO:0000269|PubMed:15650770, ECO:0000269|PubMed:20363878, ECO:0000269|PubMed:21084607, ECO:0000269|PubMed:21291561}.
uniprot
proteins
mass_dalton
96208
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. {ECO:0000250}.
uniprot
proteins
protein_family
AXL/UFO subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
10227296
uniprot
proteins
pubmed
10627473
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15650770
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20363878
uniprot
proteins
pubmed
20978472
uniprot
proteins
pubmed
21084607
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21291561
uniprot
proteins
pubmed
7511603
uniprot
proteins
pubmed
7723626
uniprot
proteins
pubmed
7784069
uniprot
proteins
pubmed
7857657
uniprot
proteins
pubmed
8058320
uniprot
proteins
pubmed
8108111
uniprot
proteins
pubmed
8108112
uniprot
proteins
pubmed
8889809
uniprot
proteins
sequence_length
880
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 420..440; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins