Astl
entrez
215095
canonical
uniprot
Q6HA09
canonical
ensembl
ENSMUSG00000050468
resolver
ensp
ENSMUSP00000054456
resolver
ensp
ENSMUSP00000087102
resolver
genesymbol
Astl
resolver
genesymbol_syn
Sas1b
resolver
uniprot
A2AHU0
resolver
uniprot
A2AHU1
resolver
uniprot
G7Z016
resolver
uniprot
G7Z017
resolver
uniprot
G7Z018
resolver
uniprot
G7Z019
resolver
uniprot
Q8BMA1
resolver
uniprot_entry
ASTL_MOUSE
resolver
uniprot_sec
A2AHU0
resolver
uniprot_sec
A2AHU1
resolver
uniprot_sec
G7Z016
resolver
uniprot_sec
G7Z017
resolver
uniprot_sec
G7Z018
resolver
uniprot_sec
G7Z019
resolver
uniprot_sec
Q8BMA1
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by wide spectrum metalloproteinase inhibitor Batimastat (BB94). Also inhibited by EDTA (By similarity). {ECO:0000250|UniProtKB:Q6HA08}.
uniprot
proteins
amino_acid_sequence
MGIMGSLWPWILTMLSLLGLSMGAPSASRCSGVCSTSVPEGFTPEGSPVFQDKDIPAINQGLISEETPESSFLVEGDIIRPSPFRLLSVTNNKWPKGVGGFVEIPFLLSRKYDELSRRVIMDAFAEFERFTCIRFVAYHGQRDFVSILPMAGCFSGVGRSGGMQVVSLAPTCLRKGRGIVLHELMHVLGFWHEHSRADRDRYIQVNWNEILPGFEINFIKSRSTNMLVPYDYSSVMHYGRFAFSWRGQPTIIPLWTSSVHIGQRWNLSTSDITRVCRLYNCSRSVPDSHGRGFEAQSDGSSLTPASISRLQRLLEALSEESGSSAPSGSRTGGQSIAGLGNSQQGWEHPPQSTFSVGALARPPQMLADASKSGPGAGADSLSLEQFQLAQAPTVPLALFPEARDKPAPIQDAFERLAPLPGGCAPGSHIREVPRD
uniprot
proteins
ec_number
3.4.-.-
uniprot
proteins
function
FUNCTION: Oocyte-specific oolemmal receptor involved in sperm and egg adhesion and fertilization. Plays a role in the polyspermy inhibition. Probably acts as a protease for the post-fertilization cleavage of ZP2. Cleaves the sperm-binding ZP2 at the surface of the zona pellucida after fertilization and cortical granule exocytosis, rendering the zona pellucida unable to support further sperm binding. {ECO:0000269|PubMed:22206759, ECO:0000269|PubMed:22472438}.
uniprot
proteins
mass_dalton
47455
uniprot
proteins
pubmed
15087446
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22206759
uniprot
proteins
pubmed
22275110
uniprot
proteins
pubmed
22472438
uniprot
proteins
pubmed
30808003
uniprot
proteins
sequence_length
435
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22206759, ECO:0000269|PubMed:22472438}. Cell membrane {ECO:0000269|PubMed:22206759}. Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000269|PubMed:22472438}. Note=Probably exocytosed from cortical granules during post-fertilization. Detected throughout the ooplasm of germinal vesicle stage oocytes in early bilaminar secondary follicles at postnatal (PN) day 3. Detected in the microvillar domain of the oolemma in arrested ovulated secondary oocytes and in the first polar body prior to fertilization. Upon fertilization, detected in the perivitelline space (PVS) and occasionally on the oolemma in 2-cell through morulae stages. Colocalizes with SPACA3 at the microvillar domain of the oolemma and in the perivitelline space (PVS). {ECO:0000269|PubMed:22472438}.
uniprot
proteins