Slc32a1
entrez
22348
canonical
uniprot
O35633
canonical
ensembl
ENSMUSG00000037771
resolver
ensp
ENSMUSP00000036299
resolver
genesymbol
Slc32a1
resolver
genesymbol_syn
Vgat
resolver
genesymbol_syn
Viaat
resolver
uniprot
Q49S98
resolver
uniprot_entry
Q49S98_MOUSE
resolver
uniprot_entry
VIAAT_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Chloride ions activate 4-aminobutanoate/H(+) transport. {ECO:0000269|PubMed:26912364}.
uniprot
proteins
amino_acid_sequence
MATLLRSKLTNVATSVSNKSQAKVSGMFARMGFQAATDEEAVGFAHCDDLDFEHRQGLQMDILKSEGEPCGDEGAEAPVEGDIHYQRGGAPLPPSGSKDQAVGAGGEFGGHDKPKITAWEAGWNVTNAIQGMFVLGLPYAILHGGYLGLFLIIFAAVVCCYTGKILIACLYEENEDGEVVRVRDSYVAIANACCAPRFPTLGGRVVNVAQIIELVMTCILYVVVSGNLMYNSFPGLPVSQKSWSIIATAVLLPCAFLKNLKAVSKFSLLCTLAHFVINILVIAYCLSRARDWAWEKVKFYIDVKKFPISIGIIVFSYTSQIFLPSLEGNMQQPSEFHCMMNWTHIAACVLKGLFALVAYLTWADETKEVITDNLPGSIRAVVNLFLVAKALLSYPLPFFAAVEVLEKSLFQEGSRAFFPACYGGDGRLKSWGLTLRCALVVFTLLMAIYVPHFALLMGLTGSLTGAGLCFLLPSLFHLRLLWRKLLWHQVFFDVAIFVIGGICSVSGFVHSLEGLIEAYRTNAED
uniprot
proteins
function
FUNCTION: Antiporter that exchanges vesicular protons for cytosolic 4-aminobutanoate or to a lesser extend glycine, thus allowing their secretion from nerve terminals (PubMed:16701208, PubMed:26912364, PubMed:27601664, PubMed:9395291). The transport is equally dependent on the chemical and electrical components of the proton gradient (PubMed:27601664, PubMed:9395291). May also transport beta-alanine (By similarity). Acidification of GABAergic synaptic vesicles is a prerequisite for 4-aminobutanoate uptake (PubMed:27601664). {ECO:0000250|UniProtKB:O35458, ECO:0000269|PubMed:16701208, ECO:0000269|PubMed:26912364, ECO:0000269|PubMed:27601664, ECO:0000269|PubMed:9395291}.
uniprot
proteins
mass_dalton
57381
uniprot
proteins
mutagenesis
MUTAGEN 90; /note="A->T: In a disruption phenotype model increases presynaptic release probability leading to more severe synaptic depression during high-frequency stimulation."; /evidence="ECO:0000269|PubMed:36073542"; MUTAGEN 263; /note="V->M: In a disruption phenotype model increases presynaptic release probability leading to more severe synaptic depression during high-frequency stimulation."; /evidence="ECO:0000269|PubMed:36073542"; MUTAGEN 269; /note="L->P: In a disruption phenotype model increases presynaptic release probability leading to more severe synaptic depression during high-frequency stimulation."; /evidence="ECO:0000269|PubMed:36073542"; MUTAGEN 322; /note="F->C: In a disruption phenotype model increases presynaptic release probability leading to more severe synaptic depression during high-frequency stimulation."; /evidence="ECO:0000269|PubMed:36073542
uniprot
proteins
protein_family
Amino acid/polyamine transporter 2 family
uniprot
proteins
pubmed
10036231
uniprot
proteins
pubmed
12115694
uniprot
proteins
pubmed
12573541
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16701208
uniprot
proteins
pubmed
16800626
uniprot
proteins
pubmed
19052203
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26912364
uniprot
proteins
pubmed
27601664
uniprot
proteins
pubmed
36073542
uniprot
proteins
pubmed
9395291
uniprot
proteins
sequence_length
525
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:O35458}; Multi-pass membrane protein {ECO:0000255}. Presynapse {ECO:0000269|PubMed:19052203}. Note=Presents in glycine-, GABA- or GABA- and glycine-containing boutons. {ECO:0000250|UniProtKB:O35458}.
uniprot
proteins
transmembrane_region
TRANSMEM 133..153; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 205..225; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 266..286; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 306..326; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 342..362; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 384..404; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 439..459; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 462..482; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 490..510; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins