Ccdc181
entrez
74895
canonical
uniprot
Q80ZU5
canonical
ensembl
ENSMUSG00000026578
resolver
ensp
ENSMUSP00000027867
resolver
enst
ENSMUST00000027867
resolver
genesymbol
Ccdc181
resolver
uniprot
Q3UF07
resolver
uniprot
Q8C631
resolver
uniprot
Q9CUL9
resolver
uniprot_entry
CC181_MOUSE
resolver
uniprot_sec
Q3UF07
resolver
uniprot_sec
Q8C631
resolver
uniprot_sec
Q9CUL9
resolver
amino_acid_sequence
MDEDKDIDSKESGEYEDDFEKDLEWLINDKEKSNGSTIEMACKKEDDLDQVLKENETETELGQQLSDPDNSPKDEALPRRNDFISVPSIQPLDPISDSDSENSFQDSKPENQKDLEDEEDEEVRRYIMEKIIEANKLLQTQEPVNDKRERKLKFKDKLVDLEVPPLEDSDTCKALLENETNMSGKLSQLCISGDLEQESVLVSVTDGSCEENDRKILVERDGKFELMNLQDIESQGFLPPISSANSVEHESSQLPLRAPNPSVGGIKKEESEAKGHVLPISPAGEPLAQVPQLLPNPKNRPSSAANPDVTKKARRSNHRIQSAGVSPVTSTYCLSPRQKELQKQLERKREKLKREEEQRKLEEENEKKKENEMVFKAWLQKKREQVIEMRRVQRAKQIEDMSSRQVNRDPQQAFRLWLKKKHEEQMKERKTEELRKQEECLFFLRGTEGRERAFRQWLRRKQIEKIAEQQAVKERARQLRLEARRSKQLQSSLYSIPEAKAFRFTDHYN
uniprot
proteins
function
FUNCTION: Microtubule-binding protein that is essential for the integrity and function of the manchette, facilitating proper sperm head shaping and subsequent flagellum formation during spermatogenesis. {ECO:0000269|PubMed:39019207, ECO:0000269|PubMed:39245650, ECO:0000305|PubMed:28283191}.
uniprot
proteins
mass_dalton
59241
uniprot
proteins
protein_family
CCDC181 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
28283191
uniprot
proteins
pubmed
39019207
uniprot
proteins
pubmed
39245650
uniprot
proteins
sequence_length
509
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:28283191, ECO:0000269|PubMed:39019207, ECO:0000269|PubMed:39245650}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:28283191, ECO:0000269|PubMed:39019207, ECO:0000269|PubMed:39245650}. Cell projection, cilium {ECO:0000269|PubMed:39019207}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q5TID7}. Note=Localizes to the microtubular manchette of elongating spermatids (PubMed:28283191, PubMed:39019207, PubMed:39245650). Localizes to the sperm flagella and to the basal half of motile cilia (PubMed:28283191, PubMed:39019207, PubMed:39245650). {ECO:0000269|PubMed:28283191, ECO:0000269|PubMed:39019207, ECO:0000269|PubMed:39245650}.
uniprot
proteins