Ifitm1
entrez
68713
canonical
uniprot
Q9D103
canonical
ensembl
ENSMUSG00000025491
resolver
ensp
ENSMUSP00000026564
resolver
ensp
ENSMUSP00000101655
resolver
ensp
ENSMUSP00000101657
resolver
ensp
ENSMUSP00000266508
resolver
enst
ENSMUST00000026564
resolver
enst
ENSMUST00000106040
resolver
enst
ENSMUST00000106042
resolver
genesymbol
Ifitm1
resolver
uniprot
Q8R2S7
resolver
uniprot_entry
IFM1_MOUSE
resolver
uniprot_sec
Q8R2S7
resolver
amino_acid_sequence
MPKEQQEVVVLGSPHISTSATATTINMPEISTPDHVVWSLFNTLFMNFCCLGFVAYAYSVKSRDRKMVGDTTGAQAFASTAKCLNISSLFFTILTAIVVIVVCAIR
uniprot
proteins
function
FUNCTION: IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV), Ebola virus (EBOV), Dengue virus (DNV) and West Nile virus (WNV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Also implicated in cell adhesion and control of cell growth and migration. Plays a key role in the antiproliferative action of IFN-gamma either by inhibiting the ERK activation or by arresting cell growth in G1 phase in a p53-dependent manner. Acts as a positive regulator of osteoblast differentiation. {ECO:0000269|PubMed:18505827, ECO:0000269|PubMed:21253575}.
uniprot
proteins
mass_dalton
11524
uniprot
proteins
post_translational_modification
PTM: Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity. {ECO:0000250|UniProtKB:P13164}.
uniprot
proteins
protein_family
CD225/Dispanin family
uniprot
proteins
pubmed
12659663
uniprot
proteins
pubmed
14516695
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16326387
uniprot
proteins
pubmed
18505827
uniprot
proteins
pubmed
21166591
uniprot
proteins
pubmed
21253575
uniprot
proteins
pubmed
22363774
uniprot
proteins
sequence_length
106
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16326387}; Single-pass membrane protein {ECO:0000269|PubMed:16326387}. Lysosome membrane {ECO:0000250|UniProtKB:P13164}.
uniprot
proteins
transmembrane_region
TRANSMEM 85..105; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins