Tspan12
entrez
362326
canonical
uniprot
Q569A2
canonical
ensembl
ENSRNOG00000059016
resolver
ensembl
ENSRNOG00055021144
resolver
ensembl
ENSRNOG00060019709
resolver
ensembl
ENSRNOG00065007603
resolver
ensp
ENSRNOP00000072130
resolver
ensp
ENSRNOP00055029340
resolver
ensp
ENSRNOP00060027884
resolver
ensp
ENSRNOP00065008692
resolver
enst
ENSRNOT00000083938
resolver
enst
ENSRNOT00055036128
resolver
enst
ENSRNOT00060034042
resolver
enst
ENSRNOT00065011908
resolver
genesymbol
Tspan12
resolver
genesymbol_syn
Tm4sf12
resolver
uniprot_entry
TSN12_RAT
resolver
amino_acid_sequence
MAREDSVKCLRCLLYALNLLFWLMSISVLAVSAWMRDYLNNVLTLTAETRVEEAVILTYFPVVHPVMIAVCCFLIIVGMLGYCGTVKRNLLLLAWYFGTLLVIFCVELACGVWTYEQEVMVPVQWSDMVTLKARMTNYGLPRYRWLTHAWNYFQREFKCCGVVYFTDWLEMTEMDWPPDSCCVREFPGCSKQAHQEDLSDLYQEGCGKKMYSFLRGTKQLQVLRFLGISIGVTQILAMILTITLLWALYYDRREPGTDQMLSLKNDASQHLSCHSVELLKPSLSRIFEHTSMANSFNTHFEMEEL
uniprot
proteins
function
FUNCTION: Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activates the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
35378
uniprot
proteins
post_translational_modification
PTM: Palmitoylated; required for interaction with ADAM10. The precise position of palmitoylated residues is unclear and occurs either on Cys-9, Cys-12 and/or Cys-83 (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Tetraspanin (TM4SF) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
305
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..33; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 60..80; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 90..110; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 225..245; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins