Il9
entrez
16198
canonical
uniprot
P15247
canonical
ensembl
ENSMUSG00000021538
resolver
ensp
ENSMUSP00000022019
resolver
enst
ENSMUST00000022019
resolver
genesymbol
Il9
resolver
uniprot_entry
IL9_MOUSE
resolver
amino_acid_sequence
MLVTYILASVLLFSSVLGQRCSTTWGIRDTNYLIENLKDDPPSKCSCSGNVTSCLCLSVPTDDCTTPCYREGLLQLTNATQKSRLLPVFHRVKRIVEVLKNITCPSFSCEKPCNQTMAGNTLSFLKSLLGTFQKTEMQRQKSRP
uniprot
proteins
function
FUNCTION: Multifunctional cytokine secreted mainly by T-helper 2 lymphocytes and also mast cells or NKT cells that plays important roles in the immune response against parasites (PubMed:11070175, PubMed:19433802). Affects intestinal epithelial permeability and adaptive immunity (PubMed:12704113). In addition, induces the differentiation of specific T-cell subsets such as IL-17 producing helper T-cells (TH17) and also proliferation and differentiation of mast cells (PubMed:11070175, PubMed:19433802). Mechanistically, exerts its biological effects through a receptor composed of IL9R subunit and a signal transducing subunit IL2RG (PubMed:2145361, PubMed:7718508). Receptor stimulation results in the rapid activation of JAK1 and JAK3 kinase activities leading to STAT1, STAT3 and STAT5-mediated transcriptional programs (PubMed:10464327). Induction of differentiation genes seems to be mediated by STAT1 alone, while protection of cells from apoptosis depends on STAT3 and STAT5 (PubMed:10464327). {ECO:0000269|PubMed:10464327, ECO:0000269|PubMed:11070175, ECO:0000269|PubMed:12704113, ECO:0000269|PubMed:19433802, ECO:0000269|PubMed:2145361, ECO:0000269|PubMed:7718508}.
uniprot
proteins
mass_dalton
16075
uniprot
proteins
protein_family
IL-7/IL-9 family
uniprot
proteins
pubmed
10464327
uniprot
proteins
pubmed
11070175
uniprot
proteins
pubmed
12704113
uniprot
proteins
pubmed
19433802
uniprot
proteins
pubmed
1971295
uniprot
proteins
pubmed
2145361
uniprot
proteins
pubmed
2521242
uniprot
proteins
pubmed
2528451
uniprot
proteins
pubmed
3137580
uniprot
proteins
pubmed
7718508
uniprot
proteins
sequence_length
144
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins