KCNF1
entrez
3754
canonical
uniprot
Q9H3M0
canonical
ensembl
ENSG00000162975
resolver
ensp
ENSP00000295082
resolver
ensp
ENSP00000631169
resolver
enst
ENST00000295082
resolver
enst
ENST00000961110
resolver
genesymbol
KCNF1
resolver
hgnc
HGNC:6246
resolver
uniprot
O43527
resolver
uniprot
Q585L3
resolver
uniprot_entry
KCNF1_HUMAN
resolver
uniprot_sec
O43527
resolver
uniprot_sec
Q585L3
resolver
amino_acid_sequence
MDGSGERSLPEPGSQSSAASDDIEIVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTIFSLCDDYDPGKREFYFDRDPDAFKCVIEVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLDDCCKSHLSEKREELEEIARRVQLILDDLGVDAAEGRWRRCQKCVWKFLEKPESSCPARVVAVLSFLLILVSSVVMCMGTIPELQVLDAEGNRVEHPTLENVETACIGWFTLEYLLRLFSSPNKLHFALSFMNIVDVLAILPFYVSLTLTHLGARMMELTNVQQAVQALRIMRIARIFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVGIFVFSALGYTMEQSHPETLFKSIPQSFWWAIITMTTVGYGDIYPKTTLGKLNAAISFLCGVIAIALPIHPIINNFVRYYNKQRVLETAAKHELELMELNSSSGGEGKTGGSRSDLDNLPPEPAGKEAPSCSSRLKLSHSDTFIPLLTEEKHHRTRLQSCK
uniprot
proteins
function
FUNCTION: Regulatory alpha-subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1 or KCNB2, can modulate their expression and their gating kinetics by acting on deactivation upon repolarization and inactivation during maintained depolarization. Accelerates inactivation but has relatively little effect on deactivation. Coexpression with KCNB1 or KCNB2 markedly slows inactivation. Each modulatory subunit has its own specific properties of regulation, and can lead to extensive inhibitions, to large changes in kinetics, and/or to large shifts in the voltage dependencies of the inactivation process. The gating kinetics depends on the nature and stoichiometry of the associated regulatory sunbunit. Fails to produce a potassium current when expressed alone. {ECO:0000250|UniProtKB:D4ADX7}.
uniprot
proteins
mass_dalton
55584
uniprot
proteins
protein_family
F (TC 1.A.1.2) subfamily
uniprot
proteins
protein_family
Kv5.1/KCNF1 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
9434767
uniprot
proteins
sequence_length
494
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q14721}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 184..204; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 224..244; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 250..270; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 290..310; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 325..345; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 386..406; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins