MIA2
entrez
4253
canonical
uniprot
Q96PC5
canonical
ensembl
ENSG00000150527
resolver
ensp
ENSP00000280082
resolver
ensp
ENSP00000280083
resolver
ensp
ENSP00000339286
resolver
ensp
ENSP00000343897
resolver
ensp
ENSP00000343912
resolver
ensp
ENSP00000379462
resolver
ensp
ENSP00000379468
resolver
ensp
ENSP00000450449
resolver
ensp
ENSP00000450869
resolver
ensp
ENSP00000452562
resolver
ensp
ENSP00000491014
resolver
ensp
ENSP00000539743
resolver
ensp
ENSP00000539744
resolver
ensp
ENSP00000539745
resolver
genesymbol
CTAGE5
resolver
genesymbol
MIA2
resolver
genesymbol_syn
CTAGE5
resolver
genesymbol_syn
MEA11
resolver
genesymbol_syn
MEA6
resolver
genesymbol_syn
MGEA11
resolver
genesymbol_syn
MGEA6
resolver
hgnc
HGNC:18432
resolver
uniprot
A0A193H6U5
resolver
uniprot
A1L4H0
resolver
uniprot
B3KRA6
resolver
uniprot
B4DQS6
resolver
uniprot
D3DSA6
resolver
uniprot
G3XAC5
resolver
uniprot
O00169
resolver
uniprot
O15320
resolver
uniprot
Q4G155
resolver
uniprot
Q59FD2
resolver
uniprot
Q6MZN2
resolver
uniprot
Q6P2R8
resolver
uniprot
Q86TF6
resolver
uniprot
Q8IX92
resolver
uniprot
Q8IX93
resolver
uniprot
Q9H6C1
resolver
uniprot_entry
MIA2_HUMAN
resolver
uniprot_entry
Q4G155_HUMAN
resolver
uniprot_entry
Q59FD2_HUMAN
resolver
uniprot_sec
A0A193H6U5
resolver
uniprot_sec
A1L4H0
resolver
uniprot_sec
B3KRA6
resolver
uniprot_sec
B4DQS6
resolver
uniprot_sec
D3DSA6
resolver
uniprot_sec
G3XAC5
resolver
uniprot_sec
O00169
resolver
uniprot_sec
O15320
resolver
uniprot_sec
Q6MZN2
resolver
uniprot_sec
Q6P2R8
resolver
uniprot_sec
Q86TF6
resolver
uniprot_sec
Q8IX92
resolver
uniprot_sec
Q8IX93
resolver
uniprot_sec
Q9H6C1
resolver
amino_acid_sequence
MAKFGVHRILLLAISLTKCLESTKLLADLKKCGDLECEALINRVSAMRDYRGPDCRYLNFTKGEEISVYVKLAGEREDLWAGSKGKEFGYFPRDAVQIEEVFISEEIQMSTKESDFLCLLGVSYTFDNEDSELNGDYGENIYPYEEDKDEKSSIYESDFQIEPGFYATYESTLFEDQVPALEAPEDIGSTSESKDWEEVVVESMEQDRIPEVHVPPSSAVSGVKEWFGLGGEQAEEKAFESVIEPVQESSFRSRKIAVEDENDLEELNNGEPQTEHQQESESEIDSVPKTQSELASESEHIPKPQSTGWFGGGFTSYLGFGDEDTGLELIAEESNPPLQDFPNSISSDKEATVPCTEILTEKKDTITNDSLSLKPSWFDFGFAILGFAYAKEDKIMLDDRKNEEDGGADEHEHPLTSELDPEKEQEIETIKIIETEDQIDKKPVSEKTDESDTIPYLKKFLYNFDNPWNFQNIPKETELPFPKQILDQNNVIENEETGEFSIDNYPTDNTKVMIFKSSYSLSDMVSNIELPTRIHEEVYFEPSSSKDSDENSKPSVDTEGPALVEIDRSVENTLLNSQMVSTDNSLSSQNYISQKEDASEFQILKYLFQIDVYDFMNSAFSPIVILTERVVAALPEGMRPDSNLYGFPWELVICAAVVGFFAVLFFLWRSFRSVRSRLYVGREKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEATCEKLNRSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQVSELNKQKVTFEDSKVHAEQVLNDKESHIKTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENGAYLDNPPKGALKKLIHAAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNLQTEQASLQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKENAHNRQKLTETELKFELLEKDPYALDVPNTAFGREHSPYGPSPLGWPSSETRAFLSPPTLLEGPLRLSPLLPGGGGRGSRGPGNPLDHQITNERGESSCDRLTDPHRAPSDTGSLSPPWDQDRRMMFPPPGQSYPDSALPPQRQDRFCSNSGRLSGPAELRSFNMPSLDKMDGSMPSEMESSRNDTKDDLGNLNVPDSSLPAENEATGPGFVPPPLAPIRGPLFPVDARGPFLRRGPPFPPPPPGAMFGASRDYFPPGDFPGPPPAPFAMRNVYPPRGFPPYLPPRPGFFPPPPHSEGRSEFPSGLIPPSNEPATEHPEPQQET
uniprot
proteins
disease_involvement
DISEASE: Note=Autoantibodies against MIA2 are present in several cancer types, including benign meningioma and cutaneous T-cell lymphoma (CTCL).
uniprot
proteins
function
FUNCTION: Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum (PubMed:21525241, PubMed:25202031, PubMed:27138255, PubMed:27170179). Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (PubMed:21525241, PubMed:25202031, PubMed:27170179). {ECO:0000250|UniProtKB:Q91ZV0, ECO:0000269|PubMed:21525241, ECO:0000269|PubMed:25202031, ECO:0000269|PubMed:27138255, ECO:0000269|PubMed:27170179}.
uniprot
proteins
mass_dalton
159836
uniprot
proteins
mutagenesis
MUTAGEN 679; /note="Y->A: No effect on interaction with PERB."; /evidence="ECO:0000269|PubMed:27170179"; MUTAGEN 697; /note="K->A: Loss of interaction with PERB. Unable to recruit PERB to the endoplasmic reticulum exit sites. Loss of function in collagen VII transport. No effect on interaction with MIA3."; /evidence="ECO:0000269|PubMed:27170179"; MUTAGEN 705; /note="S->A: Decreased interaction with PERB. No effect on interaction with MIA3."; /evidence="ECO:0000269|PubMed:27170179"; MUTAGEN 720; /note="L->A: No effect on interaction with PERB."; /evidence="ECO:0000269|PubMed:27170179
uniprot
proteins
protein_family
MIA/OTOR family
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
12586826
uniprot
proteins
pubmed
12839582
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21525241
uniprot
proteins
pubmed
21807889
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25202031
uniprot
proteins
pubmed
27138255
uniprot
proteins
pubmed
27170179
uniprot
proteins
pubmed
27551091
uniprot
proteins
pubmed
28442536
uniprot
proteins
pubmed
9356211
uniprot
proteins
sequence_length
1412
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21525241, ECO:0000269|PubMed:21807889, ECO:0000269|PubMed:25202031, ECO:0000269|PubMed:28442536}; Single-pass membrane protein {ECO:0000269|PubMed:21807889}. Note=Localizes to endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). {ECO:0000269|PubMed:21525241, ECO:0000269|PubMed:21807889, ECO:0000269|PubMed:25202031, ECO:0000269|PubMed:28442536}.
uniprot
proteins
transmembrane_region
TRANSMEM 647..667; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins