PHACTR4
entrez
65979
canonical
uniprot
Q8IZ21
canonical
ensembl
ENSG00000204138
resolver
ensp
ENSP00000362942
resolver
ensp
ENSP00000362945
resolver
ensp
ENSP00000567362
resolver
ensp
ENSP00000567363
resolver
ensp
ENSP00000626598
resolver
genesymbol
PHACTR4
resolver
hgnc
HGNC:25793
resolver
uniprot
A2APK6
resolver
uniprot
B9ZVW0
resolver
uniprot
D3DPM3
resolver
uniprot
Q68DD4
resolver
uniprot
Q6NUN6
resolver
uniprot
Q8N384
resolver
uniprot
Q9H395
resolver
uniprot
Q9H6X0
resolver
uniprot
Q9H8W6
resolver
uniprot_entry
PHAR4_HUMAN
resolver
uniprot_sec
A2APK6
resolver
uniprot_sec
B9ZVW0
resolver
uniprot_sec
D3DPM3
resolver
uniprot_sec
Q68DD4
resolver
uniprot_sec
Q6NUN6
resolver
uniprot_sec
Q8N384
resolver
uniprot_sec
Q9H395
resolver
uniprot_sec
Q9H6X0
resolver
uniprot_sec
Q9H8W6
resolver
amino_acid_sequence
MEDPFEEADQPTTEPGMVLDSVEAGDTTPPTKRKSKFSGFGKIFKPWKWRKKKSSDKFKETSEVLERKISMRKPREELVKRGVLLEDPEQGGEDPGKPSDAMLKNGHTTPIGNARSSSPVQVEEEPVRLASLRKAIPEEDLKKRLGSTGSQPNSEAESVPENVPKPPLLPPKRPLSSSHEASEGQAKDATSSGGTARFIISTSITTAPAATTAATSLAKTVNLSVTPSPAPRTLPAAPASTNTTATPSLTHMVPAKQPPIPPPKPAHRNSNPVIAELSQAINSGTLLSKPSPPLPPKRGIPSTSVPTLESAAAITTKTPSDEREKSTCSMGSELLPMISPRSPSPPLPTHIPPEPPRTPPFPAKTFQVVPEIEFPPSLDLHQEIPQQEDQKKEVPKRILDQNFGEPHIPSRLPPLPLHIRIQQALTSPLPMTPILEGSHRAHSLLFENSDSFSEDSSTLGRTRSLPITIEMLKVPDDEEEEEQTCPSTFSEEMTPTSVIPKLPQCLREEEEKESDSDSEGPIQYRDEEDEDESYQSALANKVKRKDTLAMKLNHRPSEPELNLNSWPCKSKEEWNEIRHQIGNTLIRRLSQRPTPEELEQRNILQPKNEADRQAEKREIKRRLTRKLSQRPTVAELLARKILRFNEYVEVTDAQDYDRRADKPWTKLTPADKAAIRKELNEFKSSEMEVHEESKHFTRYHRP
uniprot
proteins
function
FUNCTION: Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
78211
uniprot
proteins
protein_family
Phosphatase and actin regulator family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
702
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}.
uniprot
proteins