Cbx5
entrez
12419
canonical
uniprot
Q61686
canonical
ensembl
ENSMUSG00000009575
resolver
ensp
ENSMUSP00000104441
resolver
ensp
ENSMUSP00000113157
resolver
ensp
ENSMUSP00000113158
resolver
ensp
ENSMUSP00000320362
resolver
ensp
ENSMUSP00000320364
resolver
ensp
ENSMUSP00000320366
resolver
ensp
ENSMUSP00000320367
resolver
ensp
ENSMUSP00000320368
resolver
ensp
ENSMUSP00000337769
resolver
ensp
ENSMUSP00000351715
resolver
enst
ENSMUST00000108813
resolver
enst
ENSMUST00000118152
resolver
enst
ENSMUST00000122182
resolver
genesymbol
Cbx5
resolver
genesymbol_syn
Hp1a
resolver
uniprot
Q9CS35
resolver
uniprot
Q9CXD1
resolver
uniprot_entry
CBX5_MOUSE
resolver
uniprot_sec
Q9CS35
resolver
uniprot_sec
Q9CXD1
resolver
amino_acid_sequence
MGKKTKRTADSSSSEDEEEYVVEKVLDRRMVKGQVEYLLKWKGFSEEHNTWEPEKNLDCPELISEFMKKYKKMKEGENNKPREKSEGNKRKSSFSNSADDIKSKKKREQSNDIARGFERGLEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKCPQIVIAFYEERLTWHAYPEDAENKEKESAKS
uniprot
proteins
function
FUNCTION: Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Also recognizes and binds histone H1.4 methylated at 'Lys-26' (H1.4K26me). Excluded from chromatin when histone H1.4 is Simultaneously methylated at Lys-26 (H1.4K26me) and phosphorylated at Ser-27 (H1.4S27Ph). May contribute to the association of heterochromatin with the inner nuclear membrane by interactions with the lamin-B receptor (LBR). Involved in the formation of kinetochore through interaction with the MIS12 complex subunit NSL1. Required for the formation of the inner centromere. {ECO:0000250|UniProtKB:P45973}.
uniprot
proteins
mass_dalton
22186
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of HP1 and LBR may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis. {ECO:0000250|UniProtKB:P45973}.; PTM: Ubiquitinated. {ECO:0000250|UniProtKB:P45973}.
uniprot
proteins
pubmed
10562550
uniprot
proteins
pubmed
11107181
uniprot
proteins
pubmed
15145825
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28250819
uniprot
proteins
pubmed
8978696
uniprot
proteins
sequence_length
191
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P45973}. Chromosome {ECO:0000250|UniProtKB:P45973}. Chromosome, centromere {ECO:0000250|UniProtKB:P45973}. Note=Colocalizes with HNRNPU in the nucleus. Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase. Localizes to sites of DNA damage. {ECO:0000250|UniProtKB:P45973}.
uniprot
proteins