Mecp2
entrez
17257
canonical
uniprot
Q9Z2D6
canonical
ensembl
ENSMUSG00000031393
resolver
ensp
ENSMUSP00000033770
resolver
ensp
ENSMUSP00000098314
resolver
genesymbol
Mecp2
resolver
uniprot
B1AUZ2
resolver
uniprot
B1AUZ3
resolver
uniprot
Q3TYG1
resolver
uniprot_entry
MECP2_MOUSE
resolver
uniprot_sec
B1AUZ2
resolver
uniprot_sec
B1AUZ3
resolver
uniprot_sec
Q3TYG1
resolver
amino_acid_sequence
MVAGMLGLREEKSEDQDLQGLRDKPLKFKKAKKDKKEDKEGKHEPLQPSAHHSAEPAEAGKAETSESSGSAPAVPEASASPKQRRSIIRDRGPMYDDPTLPEGWTRKLKQRKSGRSAGKYDVYLINPQGKAFRSKVELIAYFEKVGDTSLDPNDFDFTVTGRGSPSRREQKPPKKPKSPKAPGTGRGRGRPKGSGTGRPKAAASEGVQVKRVLEKSPGKLVVKMPFQASPGGKGEGGGATTSAQVMVIKRPGRKRKAEADPQAIPKKRGRKPGSVVAAAAAEAKKKAVKESSIRSVHETVLPIKKRKTRETVSIEVKEVVKPLLVSTLGEKSGKGLKTCKSPGRKSKESSPKGRSSSASSPPKKEHHHHHHHSESTKAPMPLLPSPPPPEPESSEDPISPPEPQDLSSSICKEEKMPRGGSLESDGCPKEPAKTQPMVATTTTVAEKYKHRGEGERKDIVSSSMPRPNREEPVDSRTPVTERVS
uniprot
proteins
function
FUNCTION: Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Mediates transcriptional repression through interaction with histone deacetylase and the corepressor SIN3. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). {ECO:0000269|PubMed:23434322}.
uniprot
proteins
mass_dalton
52307
uniprot
proteins
mutagenesis
MUTAGEN 158; /note="T->M: Loss of localization to the nucleus. Distributes diffusely in cells. Interacts normally with NCOR2."; /evidence="ECO:0000269|PubMed:23770565"; MUTAGEN 302; /note="P->R: Abolishes interaction with NCOR2."; /evidence="ECO:0000269|PubMed:23770565"; MUTAGEN 304; /note="K->E: Abolishes interaction with NCOR2."; /evidence="ECO:0000269|PubMed:23770565"; MUTAGEN 305; /note="K->R: Abolishes interaction with NCOR2."; /evidence="ECO:0000269|PubMed:23770565"; MUTAGEN 306; /note="R->C: Abolishes interaction with NCOR2. Mice exhibit a severe neurological Rett syndrome-like phenotype."; /evidence="ECO:0000269|PubMed:23770565
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser-421 by CaMK2 in brain upon synaptic activity, which attenuates its repressor activity and seems to regulate dendritic growth and spine maturation. Does not seem to be phosphorylated on Ser-421 in other tissues. {ECO:0000269|PubMed:17046689}.
uniprot
proteins
pubmed
10369871
uniprot
proteins
pubmed
15034150
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17046689
uniprot
proteins
pubmed
17296936
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23434322
uniprot
proteins
pubmed
23770565
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
28348241
uniprot
proteins
pubmed
9171351
uniprot
proteins
pubmed
9774669
uniprot
proteins
sequence_length
484
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15034150, ECO:0000269|PubMed:17296936}. Note=Colocalized with methyl-CpG in the genome. Colocalized with TBL1X to the heterochromatin foci. {ECO:0000250|UniProtKB:P51608}.
uniprot
proteins