MLLT1
entrez
4298
canonical
uniprot
Q03111
canonical
ensembl
ENSG00000130382
resolver
ensp
ENSP00000252674
resolver
ensp
ENSP00000537722
resolver
enst
ENST00000252674
resolver
genesymbol
MLLT1
resolver
genesymbol_syn
ENL
resolver
genesymbol_syn
LTG19
resolver
genesymbol_syn
YEATS1
resolver
hgnc
HGNC:7134
resolver
uniprot
Q14768
resolver
uniprot_entry
ENL_HUMAN
resolver
uniprot_sec
Q14768
resolver
activity_regulation
ACTIVITY REGULATION: Acylated lysine-binding is specifically inhibited by the tripeptide XL-13m, carrying a 2-furancarbonyl side chain, preventing recruitment to chromatin. {ECO:0000269|PubMed:30374167}.
uniprot
proteins
amino_acid_sequence
MDNQCTVQVRLELGHRAQLRKKPTTEGFTHDWMVFVRGPEQCDIQHFVEKVVFWLHDSFPKPRRVCKEPPYKVEESGYAGFIMPIEVHFKNKEEPRKVCFTYDLFLNLEGNPPVNHLRCEKLTFNNPTTEFRYKLLRAGGVMVMPEGADTVSRPSPDYPMLPTIPLSAFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKDTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETKLESTSPKGGPPPPPPPPPRASSKRPATADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPREAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVEDLQSEESDEDDSSSGEEAAGKTNPGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPPPNSKVSGRRSPESCSKPEKILKKGTYDKAYTDELVELHRRLMALRERNVLQQIVNLIEETGHFNVTNTTFDFDLFSLDETTVRKLQSCLEAVAT
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving MLLT1 is associated with acute leukemias. Translocation t(11;19)(q23;p13.3) with KMT2A/MLL1. The result is a rogue activator protein.
uniprot
proteins
function
FUNCTION: Chromatin reader component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA (PubMed:20159561, PubMed:20471948). Specifically recognizes and binds acetylated and crotonylated histones, with a preference for histones that are crotonylated (PubMed:27105114). Has a slightly higher affinity for binding histone H3 crotonylated at 'Lys-27' (H3K27cr) than 'Lys-20' (H3K9cr20) (PubMed:27105114). May play a role in leukemogenic gene transcription (PubMed:39794553). {ECO:0000269|PubMed:20159561, ECO:0000269|PubMed:20471948, ECO:0000269|PubMed:27105114, ECO:0000269|PubMed:39794553}.; FUNCTION: Acts as a key chromatin reader in acute myeloid leukemia by recognizing and binding to acetylated histones via its YEATS domain, thereby regulating oncogenic gene transcription. {ECO:0000269|PubMed:28241139, ECO:0000269|PubMed:28241141}.
uniprot
proteins
mass_dalton
62056
uniprot
proteins
pubmed
12665591
uniprot
proteins
pubmed
1423624
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20159561
uniprot
proteins
pubmed
20471948
uniprot
proteins
pubmed
22195968
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23145062
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
27105114
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28241139
uniprot
proteins
pubmed
28241141
uniprot
proteins
pubmed
30374167
uniprot
proteins
pubmed
39794553
uniprot
proteins
pubmed
8080983
uniprot
proteins
pubmed
8378076
uniprot
proteins
sequence_length
559
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins