Dbr1
entrez
83703
canonical
uniprot
Q923B1
canonical
ensembl
ENSMUSG00000032469
resolver
ensp
ENSMUSP00000070991
resolver
enst
ENSMUST00000066650
resolver
genesymbol
Dbr1
resolver
uniprot
Q8C1T9
resolver
uniprot
Q8C7J7
resolver
uniprot
Q99MT1
resolver
uniprot_entry
DBR1_MOUSE
resolver
uniprot_sec
Q8C1T9
resolver
uniprot_sec
Q8C7J7
resolver
uniprot_sec
Q99MT1
resolver
activity_regulation
ACTIVITY REGULATION: Active in presence of diverse metals including Fe(2+), Zn(2+), Mn(2+) (By similarity). Also activated by Ca(2+) (By similarity). Binds two metal cations in two adjacent alpha and beta metal-binding pockets (By similarity). {ECO:0000250|UniProtKB:P24309, ECO:0000250|UniProtKB:Q9UK59}.
uniprot
proteins
amino_acid_sequence
MRVAVAGCCHGELDKIYETLALAERRGSGPVDLLLCCGDFQAVRNEADLRCMAVPPKYRHMQTFYRYYSGEKKAPVLTIFIGGNHEASNHLQELPYGGWVAPNIYYLGLAGVVKYRGVRIGGISGIFKSHDYRKGHFECPPYNSSTIRSIYHVRNIEVYKLKQLKQPVHIFLSHDWPRNIYHYGNKKQLLKTKSFFRQEVENSTLGSPAASELLEHLQPAYWFSAHLHVKFAALMQHQATDKDQAGKETKFLALDKCLPHRDFLQVLEIEHDPSAPEYLEYDVEWLTVLRATDDLINVTGGLWNMPEDNGLHTRWDYSATEETMKEVMEKLNHDPKVPCNFTMTAACYDPSKPQTQVKLVHRINPQTTEFCAQLGITDINVMIQKAREEEHHQCGEYEQQGDPGTEESEEDRSEYNTDTSALSSINPDEIMLDEEEEEEEEEEEAVSAHSDMNTPSVEPASDQASDLSTSFSDIRNLPSSMFVSSDDASRSPASGEGKCGETVESGDEKDLAKFPLKRLSDEHEPEQRKKIKRRNQAIYAAVDDGDASAE
uniprot
proteins
ec_number
3.1.4.-
uniprot
proteins
function
FUNCTION: Cleaves the 2'-5' phosphodiester linkage at the branch point of excised lariat intron RNA and converts them into linear molecules that can be subsequently degraded, thereby facilitating ribonucleotide turnover (PubMed:11355701). Linked to its role in pre-mRNA processing mechanism, may also participate in retrovirus replication and have an antiviral cell-intrinsic defense function (By similarity). {ECO:0000250|UniProtKB:Q9UK59, ECO:0000269|PubMed:11355701}.
uniprot
proteins
mass_dalton
62289
uniprot
proteins
protein_family
Lariat debranching enzyme family
uniprot
proteins
pubmed
11355701
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
550
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UK59}.
uniprot
proteins