Abca5
entrez
217265
canonical
uniprot
Q8K448
canonical
ensembl
ENSMUSG00000018800
resolver
ensp
ENSMUSP00000047927
resolver
ensp
ENSMUSP00000315868
resolver
enst
ENSMUST00000043961
resolver
genesymbol
Abca5
resolver
genesymbol_syn
Kiaa1888
resolver
uniprot
Q3TE17
resolver
uniprot
Q3UUB4
resolver
uniprot
Q6P1Y0
resolver
uniprot
Q6ZPG4
resolver
uniprot
Q810C7
resolver
uniprot
Q8BM46
resolver
uniprot
Q8BXG7
resolver
uniprot_entry
ABCA5_MOUSE
resolver
uniprot_sec
Q3TE17
resolver
uniprot_sec
Q3UUB4
resolver
uniprot_sec
Q6P1Y0
resolver
uniprot_sec
Q6ZPG4
resolver
uniprot_sec
Q810C7
resolver
uniprot_sec
Q8BM46
resolver
uniprot_sec
Q8BXG7
resolver
amino_acid_sequence
MATAIRDVGVWRQTRTLLLKNYLIKCRTKKSSVQEILFPLFFLFWLILVSMMHPNKKYEEVSDIELSPMDKFSLSNVILGYTPVTNITSSIMQRVSTDHLPKVIVTEEYANEKELVAASLSKSSNFVGVVFKDTMSYELRFFPEMIPVSSIYMNSREGCSKTCDAAQYWSLGFTVLQASIDAAIIQLKTNVSVWSELESTKAVIMGEAAVVEIDTFPRGVILIYLVIAFSPFGYFLAIHIVAEKEKKLKEFLKIMGLHDTAFWLSWVLLYASLIFLMSLLMAVIATASSLFPQSSSIVIFLLFFLYGLSSVFFALMLTPLFKKSKHVGVVEFFVTVVFGFVGLLIVLIESFPRSLVWLFSPLCQCAFLIGIAQVMHLEDFNEGALFSNLTEGPYPLIITIIMLALDSVFYVLLAVYLDQVIPGEFGLRRSSLYFLKPSYWSKNKRNYKELSEGNINGNISLNEIVEPVSSEFIGKEAIRISGIQKSYRKKTENVEALRNLSFDIYEGQITALLGHSGTGKSTLMNILCGLCPPSDGFASIYGHRVSEIDEMFEARKMIGICPQSDINFDVLTVEENLSILASIKGIPANNIIQEVQKVLLDLDMQAIKDNQAKKLSGGQKRKLSVGIAVLGNPKILLLDEPTAGMDPCSRHIVWNLLKYRKANRVTVFSTHFMDEADILADRKAVISQGMLKCVGSSIFLKSKWGIGYRLSMYIDRYCATESLSSLVRQHIPAAALLQQNDQQLVYSLPFKDMDKFSGLFSALDIHSNLGVISYGVSMTTLEDVFLKLEVEAEIDQADYSVFTQQPREEETDSKSFDEMEQSLLILSETKASSVSTMSLWKQQVSTIAKFHFLSLKRESKSVRAVLLLLLIFFAVQIFMFFLHHSFKNAVVPIKLVPDLYFLKPGDKPHKYKTSLLLQNSTDSDINGLIEFFAHQNIMVAMFNDSDYVSAAPHSAALNVVRSEKDYVFSAVFNSTMVYCLPVMMNIISNYYLYHLNVTEAIQTWSTPFIQEITDIVFKIELYFQAALLGIIVTAMPPYFAMENAENHKIKAYTQLKLSGLLPSAYWVGQAVVDIPLFFVVLILMLGSLFAFHHGLYFYPAKFLAVVFCLIAYVPSVILFTYIASFTFKKILNTKEFWSFIYSVTALACVAITETTFFLQYAVTAVFHYTFCIAIPIYPLLGCLISFIKGSWKNMPKNENTYNPWDRLLVAVIMPYLQCILWIFLLQHYEKIHGGRSIRKDPFFRALSQKAKNKKFPEPPINEDEDEDVKAERLKVKELMGCQCCEEKPAIMVCNLHKEYDDKKDFLHSRKTTKVATKYISFCVKKGEILGLLGPNGAGKSTVINTLVGDVEPTSGKIFLGDYGSHSSEDDESIKCMGYCPQTNPLWPDLTLQEHFEIYGAVKGMSPGDMKEVISRITKALDLKEHLQKTVKKLPAGIKRKLCFALSMLGNPQVTLLDEPSTGMDPRAKQHMWRAIRTAFKNKKRAALLTTHYMEEAEAVCDRVAIMVSGQLRCIGTVQHLKSKFGKGYFLEIKLKDWIENLEIDRLQREIQYIFPNASRQESFSSILAFKIPKEDVQSLSQSFAKLEEAKRTFAIEEYSFSQATLEQVFVELTKEQEEEDNSCGTLASTLWWERTQEDRVVF
uniprot
proteins
ec_number
7.6.2.-
uniprot
proteins
function
FUNCTION: Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport (PubMed:20382126, PubMed:25125465, PubMed:32687853). May play a role in the processing of autolysosomes (PubMed:15870284). {ECO:0000269|PubMed:15870284, ECO:0000269|PubMed:20382126, ECO:0000269|PubMed:25125465, ECO:0000269|PubMed:32687853}.
uniprot
proteins
mass_dalton
185895
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:15870284}.
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCA family
uniprot
proteins
pubmed
12532264
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15870284
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16445568
uniprot
proteins
pubmed
20382126
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24831815
uniprot
proteins
pubmed
25125465
uniprot
proteins
pubmed
32687853
uniprot
proteins
sequence_length
1642
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8CF82}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8CF82}. Lysosome membrane {ECO:0000269|PubMed:15870284}; Multi-pass membrane protein {ECO:0000269|PubMed:15870284}. Late endosome membrane {ECO:0000269|PubMed:15870284}; Multi-pass membrane protein {ECO:0000269|PubMed:15870284}. Cell membrane {ECO:0000269|PubMed:32687853}. Note=Localized at cell membrane under high cholesterol levels. {ECO:0000269|PubMed:32687853}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..52; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 220..240; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 264..284; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 297..317; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 328..348; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 355..375; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 396..416; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 864..884; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 967..987; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1021..1041; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1071..1091; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1102..1122; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1138..1158; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1164..1184; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1207..1227; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins