SCAI
entrez
286205
canonical
uniprot
Q8N9R8
canonical
ensembl
ENSG00000173611
resolver
ensp
ENSP00000336756
resolver
ensp
ENSP00000362650
resolver
genesymbol
SCAI
resolver
genesymbol_syn
C9orf126
resolver
hgnc
HGNC:26709
resolver
uniprot
Q3SXZ1
resolver
uniprot
Q3SXZ2
resolver
uniprot
Q5T163
resolver
uniprot
Q8N1I4
resolver
uniprot_entry
SCAI_HUMAN
resolver
uniprot_sec
Q3SXZ1
resolver
uniprot_sec
Q3SXZ2
resolver
uniprot_sec
Q5T163
resolver
uniprot_sec
Q8N1I4
resolver
amino_acid_sequence
MVRGARQPQQPRSRLAPRLTGTVEKPPRKRRSRTEFALKEIMSSGGAEDDIPQGERKTVTDFCYLLDKSKQLFNGLRDLPQYGQKQWQSYFGRTFDVYTKLWKFQQQHRQVLDNRYGLKRWQIGEIASKIGQLYYHYYLRTSETSYLNEAFSFYSAIRQRSYYSQVNKEDRPELVVKKLRYYARFIVVCLLLNKMDVVKDLVKELSDEIEDYTHRFNTEDQVEWNLVLQEVAAFIEADPVMVLNDDNTIVITSNRLAETGAPLLEQGMIVGQLSLADALIIGNCNNQVKFSELTVDMFRMLQALEREPMNLASQMNKPGMQESADKPTRRENPHKYLLYKPTFSQLYTFLAASFKELPANSVLLIYLSATGVFPTGRSDSEGPYDFGGVLTNSNRDIINGDAIHKRNQSHKEMHCLHPGDLYPFTRKPLFIIVDSSNSVAYKNFTNLFGQPLVCLLSPTAYPKALQDQSQRGSLFTLFLNNPLMAFLFVSGLSSMRRGLWEKCQEYLRKINRDIAQLLTHSRSIDQAFLQFFGDEFLRLLLTRFIFCSATMRMHKIFRETRNYPESYPQLPRDETVENPHLQKHILELASILDVRNVFFENTIDDY
uniprot
proteins
function
FUNCTION: Tumor suppressor which functions to suppress MRTFA-induced SRF transcriptional activity. May function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migration through transcriptional regulation of ITGB1. {ECO:0000269|PubMed:19350017}.
uniprot
proteins
mass_dalton
70399
uniprot
proteins
protein_family
SCAI family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19350017
uniprot
proteins
sequence_length
606
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus {ECO:0000269|PubMed:19350017}. Cytoplasm {ECO:0000269|PubMed:19350017}. Note=Nuclear localization is required for inhibition of MRTFA. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 472..492; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins