PI4KB
entrez
5298
canonical
uniprot
Q9UBF8
canonical
ensembl
ENSG00000143393
resolver
ensp
ENSP00000357866
resolver
ensp
ENSP00000357867
resolver
ensp
ENSP00000357868
resolver
ensp
ENSP00000357869
resolver
ensp
ENSP00000433149
resolver
ensp
ENSP00000522807
resolver
ensp
ENSP00000522819
resolver
ensp
ENSP00000603615
resolver
ensp
ENSP00000613299
resolver
ensp
ENSP00000613302
resolver
enst
ENST00000368875
resolver
genesymbol
PI4KB
resolver
genesymbol_syn
PIK4CB
resolver
hgnc
HGNC:8984
resolver
uniprot
A0A0B4J1S8
resolver
uniprot
B4DGI2
resolver
uniprot
O15096
resolver
uniprot
P78405
resolver
uniprot
Q5VWB9
resolver
uniprot
Q5VWC0
resolver
uniprot
Q5VWC1
resolver
uniprot
Q9BWR6
resolver
uniprot_entry
A0A0B4J1S8_HUMAN
resolver
uniprot_entry
PI4KB_HUMAN
resolver
uniprot_sec
B4DGI2
resolver
uniprot_sec
O15096
resolver
uniprot_sec
P78405
resolver
uniprot_sec
Q5VWB9
resolver
uniprot_sec
Q5VWC0
resolver
uniprot_sec
Q5VWC1
resolver
uniprot_sec
Q9BWR6
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by wortmannin and adenosine (PubMed:11277933). Increased kinase activity upon interaction with NCS1/FREQ (By similarity). {ECO:0000250|UniProtKB:O02810, ECO:0000269|PubMed:11277933}.; ACTIVITY REGULATION: (Microbial infection) Activated by Aichi virus protein 3A, this activation is sensitized by ACBD3. {ECO:0000269|PubMed:24672044, ECO:0000269|PubMed:27989622}.
uniprot
proteins
amino_acid_sequence
MGDTVVEPAPLKPTSEPTSGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVKLLHGGVAVSSRGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGAAVASGTAKGARRRRQNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLLNMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLILSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVENEDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLNHKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPENRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCDNISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEKVRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKILVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGYCLVCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGGLDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSMTEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
uniprot
proteins
disease_involvement
DISEASE: Deafness, autosomal dominant, 87 (DFNA87) [MIM:620281]: A form of non-syndromic, sensorineural hearing loss. Sensorineural hearing loss results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DFNA87 is characterized by prelingual, profound sensorineural hearing loss with inner ear anomalies, including cochlear maldevelopment, absence of the osseous spiral lamina, and/or an enlarged vestibular aqueduct. {ECO:0000269|PubMed:33358777}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.1.67
uniprot
proteins
function
FUNCTION: Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity) (PubMed:10559940, PubMed:11277933, PubMed:12749687, PubMed:9405935). May play an important role in the inner ear development. {ECO:0000250|UniProtKB:O08561, ECO:0000269|PubMed:10559940, ECO:0000269|PubMed:11277933, ECO:0000269|PubMed:12749687, ECO:0000269|PubMed:33358777, ECO:0000269|PubMed:9405935}.; FUNCTION: (Microbial infection) Plays an essential role in Aichi virus RNA replication (PubMed:22124328, PubMed:22258260, PubMed:27989622). Recruited by ACBD3 at the viral replication sites (PubMed:22124328, PubMed:27989622). {ECO:0000269|PubMed:22124328, ECO:0000269|PubMed:22258260, ECO:0000269|PubMed:27989622}.; FUNCTION: (Microbial infection) Required for cellular spike-mediated entry of human coronavirus SARS-CoV. {ECO:0000269|PubMed:22253445}.
uniprot
proteins
mass_dalton
91379
uniprot
proteins
mutagenesis
MUTAGEN 40..42; /note="LSV->AAA: Small decrease in ARMH3-binding. No effect on ACBD3-, nor RAB11B-binding."; /evidence="ECO:0000269|PubMed:23572552"; MUTAGEN 42; /note="V->A: No loss of interaction with ACBD3."; /evidence="ECO:0000269|PubMed:27009356"; MUTAGEN 43..45; /note="IDP->AAA: Drastically decreased ACBD3-binding. No effect on ARMH3-, nor RAB11B-binding."; /evidence="ECO:0000269|PubMed:23572552"; MUTAGEN 43; /note="I->A: Loss of interaction with ACBD3."; /evidence="ECO:0000269|PubMed:27009356, ECO:0000269|PubMed:27989622"; MUTAGEN 44; /note="D->A: Loss of interaction with ACBD3."; /evidence="ECO:0000269|PubMed:27989622"; MUTAGEN 46..47; /note="EV->AA: No effect on ACBD3-, ARMH3-, nor RAB11B-binding."; /evidence="ECO:0000269|PubMed:23572552"; MUTAGEN 47; /note="V->A: No loss of interaction with ACBD3."; /evidence="ECO:0000269|PubMed:27009356"; MUTAGEN 49..50; /note="QK->AA: No effect on ACBD3-, ARMH3-, nor RAB11B-binding."; /evidence="ECO:0000269|PubMed:23572552"; MUTAGEN 52; /note="C->A: No effect on ACBD3-, ARMH3-, nor RAB11B-binding."; /evidence="ECO:0000269|PubMed:23572552"; MUTAGEN 53..54; /note="QE->AA: Drastically decreased ARMH3- and RAB11B-binding. 6-fold increase in ACBD3-binding."; /evidence="ECO:0000269|PubMed:23572552"; MUTAGEN 55..56; /note="VL->AA: Drastically decreased ACBD3-binding. No effect on ARMH3-, nor RAB11B-binding."; /evidence="ECO:0000269|PubMed:23572552"; MUTAGEN 55; /note="V->A: Loss of interaction with ACBD3."; /evidence="ECO:0000269|PubMed:27009356"; MUTAGEN 56; /note="L->A: Loss of interaction with ACBD3."; /evidence="ECO:0000269|PubMed:27009356"; MUTAGEN 57..59; /note="EKV->AAA: No effect on ACBD3-, ARMH3-, nor RAB11B-binding."; /evidence="ECO:0000269|PubMed:23572552
uniprot
proteins
protein_family
PI3/PI4-kinase family
uniprot
proteins
protein_family
Type III PI4K subfamily
uniprot
proteins
pubmed
10559940
uniprot
proteins
pubmed
11277933
uniprot
proteins
pubmed
12749687
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17555535
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22124328
uniprot
proteins
pubmed
22253445
uniprot
proteins
pubmed
22258260
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23572552
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24672044
uniprot
proteins
pubmed
27009356
uniprot
proteins
pubmed
27989622
uniprot
proteins
pubmed
28289207
uniprot
proteins
pubmed
30917996
uniprot
proteins
pubmed
33358777
uniprot
proteins
pubmed
9020160
uniprot
proteins
pubmed
9148941
uniprot
proteins
pubmed
9405935
uniprot
proteins
pubmed
9405938
uniprot
proteins
sequence_length
816
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endomembrane system. Mitochondrion outer membrane; Peripheral membrane protein. Rough endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus {ECO:0000269|PubMed:22124328}. Golgi apparatus membrane {ECO:0000269|PubMed:24672044, ECO:0000269|PubMed:27009356, ECO:0000269|PubMed:28289207}. Cytoplasm, perinuclear region. Note=Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex. Recruited to the Golgi apparatus membrane by ACBD3 (PubMed:24672044, PubMed:27009356, PubMed:28289207). GGA2 is also involved in the recruitment (PubMed:28289207). {ECO:0000269|PubMed:24672044, ECO:0000269|PubMed:27009356, ECO:0000269|PubMed:28289207}.
uniprot
proteins