Slc25a45
entrez
107375
canonical
uniprot
Q8CFJ7
canonical
ensembl
ENSMUSG00000024818
resolver
ensp
ENSMUSP00000025732
resolver
ensp
ENSMUSP00000117220
resolver
ensp
ENSMUSP00000121596
resolver
ensp
ENSMUSP00000158189
resolver
enst
ENSMUST00000235340
resolver
genesymbol
Slc25a45
resolver
uniprot
A0A494BAQ4
resolver
uniprot
Q3TC75
resolver
uniprot
Q3UZE9
resolver
uniprot
Q8VBZ7
resolver
uniprot_entry
A0A494BAQ4_MOUSE
resolver
uniprot_entry
S2545_MOUSE
resolver
uniprot_sec
Q3TC75
resolver
uniprot_sec
Q3UZE9
resolver
uniprot_sec
Q8VBZ7
resolver
amino_acid_sequence
MPVEEFVAGWISGAVGLVLGHPFDTVKVRLQTQSTYQGIVDCVVKTYRHESVLGFFKGMSFPIASVALVNSVLFGVYSNTLLALTATSHQERRAQPPSYTNIFIAGCTGGLLQAYCLAPFDLIKVRLQNQTEPRMQISSSMPRYRGPVHCAASILREEGPQGLFRGSWALVLRDTPTLGMYFVTYEGLCRQYTPEGQNPSSATVLVAGGFAGIASWITATPFDVIKSRMQMDGLKGRKYGGMLDCMASSFRQEGIGVFFKGMTLNSARAFPVNAATFLSYEYLLRLWR
uniprot
proteins
function
FUNCTION: Mitochondrial transporter that specifically mediates the mitochondrial uptake of dimethylarginine and trimethyllysine amino acids, and which is required for carnitine biosynthesis (PubMed:41075780). Involved in carnitine biosynthesis by mediating the mitochondrial import of trimethyllysine, a precursor for carnitine biosynthesis (PubMed:41075780). Transports both symmetric and asymmetric dimethylarginine (By similarity). Does not transport unmethylated arginine and lysine (By similarity). {ECO:0000250|UniProtKB:Q8N413, ECO:0000269|PubMed:41075780}.
uniprot
proteins
mass_dalton
31690
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved by m-AAA protease (AFG3L2), leading to its degradation. {ECO:0000250|UniProtKB:Q8N413}.
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19287344
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
41075780
uniprot
proteins
sequence_length
288
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:41075780}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 6..26; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 58..78; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 102..122; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 166..186; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 202..222; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 266..286; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins