STRAP
entrez
11171
canonical
uniprot
Q9Y3F4
canonical
ensembl
ENSG00000023734
resolver
ensp
ENSP00000392270
resolver
genesymbol
STRAP
resolver
genesymbol_syn
MAWD
resolver
genesymbol_syn
UNRIP
resolver
hgnc
HGNC:30796
resolver
uniprot
B2R5S5
resolver
uniprot
B4DNJ6
resolver
uniprot
Q5TZT4
resolver
uniprot
Q9NTK0
resolver
uniprot
Q9UQC8
resolver
uniprot_entry
STRAP_HUMAN
resolver
uniprot_sec
B2R5S5
resolver
uniprot_sec
B4DNJ6
resolver
uniprot_sec
Q5TZT4
resolver
uniprot_sec
Q9NTK0
resolver
uniprot_sec
Q9UQC8
resolver
amino_acid_sequence
MAMRQTPLTCSGHTRPVVDLAFSGITPYGYFLISACKDGKPMLRQGDTGDWIGTFLGHKGAVWGATLNKDATKAATAAADFTAKVWDAVSGDELMTLAHKHIVKTVDFTQDSNYLLTGGQDKLLRIYDLNKPEAEPKEISGHTSGIKKALWCSEDKQILSADDKTVRLWDHATMTEVKSLNFNMSVSSMEYIPEGEILVITYGRSIAFHSAVSLDPIKSFEAPATINSASLHPEKEFLVAGGEDFKLYKYDYNSGEELESYKGHFGPIHCVRFSPDGELYASGSEDGTLRLWQTVVGKTYGLWKCVLPEEDSGELAKPKIGFPETTEEELEEIASENSDCIFPSAPDVKA
uniprot
proteins
function
FUNCTION: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. {ECO:0000269|PubMed:16251192, ECO:0000269|PubMed:18984161}.
uniprot
proteins
mass_dalton
38438
uniprot
proteins
protein_family
WD repeat STRAP family
uniprot
proteins
pubmed
10049359
uniprot
proteins
pubmed
10646843
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15848170
uniprot
proteins
pubmed
16159890
uniprot
proteins
pubmed
16251192
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17178713
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18984161
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29186683
uniprot
proteins
sequence_length
350
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Localized predominantly in the cytoplasm but also found in the nucleus.
uniprot
proteins