ARF5
entrez
381
canonical
uniprot
P84085
canonical
ensembl
ENSG00000004059
resolver
ensp
ENSP00000000233
resolver
enst
ENST00000000233
resolver
genesymbol
ARF5
resolver
hgnc
HGNC:658
resolver
uniprot
A4D0Z3
resolver
uniprot
P26437
resolver
uniprot_entry
A4D0Z3_HUMAN
resolver
uniprot_entry
ARF5_HUMAN
resolver
uniprot_sec
P26437
resolver
amino_acid_sequence
MGLTVSALFSRIFGKKQMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNICFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVQESADELQKMLQEDELRDAVLLVFANKQDMPNAMPVSELTDKLGLQHLRSRTWYVQATCATQGTGLYDGLDWLSHELSKR
uniprot
proteins
function
FUNCTION: GTP-binding protein involved in protein trafficking. Contributes to vesicle budding and uncoating at the Golgi apparatus. Regulates mTORC1 activity at the plasma membrane by promoting its recruitment to membrane ruffles, facilitating activation via the PI3K/Akt signaling pathway (PubMed:36735494). Acts as an early responder to lysosomal damage and participates in lysosomal quality control pathways (PubMed:41293316). {ECO:0000269|PubMed:36735494, ECO:0000269|PubMed:41293316}.; FUNCTION: (Microbial infection) Functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. {ECO:0000305}.
uniprot
proteins
mass_dalton
20530
uniprot
proteins
mutagenesis
MUTAGEN 31; /note="T->N: No loss of interaction with RPTOR."; /evidence="ECO:0000269|PubMed:36735494"; MUTAGEN 71; /note="Q->L: Loss of interaction with RPTOR."; /evidence="ECO:0000269|PubMed:36735494
uniprot
proteins
protein_family
Arf family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10022920
uniprot
proteins
pubmed
11950392
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17030804
uniprot
proteins
pubmed
17555535
uniprot
proteins
pubmed
1993656
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25255805
uniprot
proteins
pubmed
26000619
uniprot
proteins
pubmed
36735494
uniprot
proteins
pubmed
41293316
uniprot
proteins
pubmed
9169151
uniprot
proteins
sequence_length
180
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:36735494}. Golgi apparatus {ECO:0000269|PubMed:17555535, ECO:0000269|PubMed:41293316}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:17555535}. Lysosome membrane {ECO:0000269|PubMed:41293316}; Lipid-anchor {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:36735494}; Lipid-anchor {ECO:0000250|UniProtKB:P84084}.
uniprot
proteins