NEDD1
entrez
121441
canonical
uniprot
Q8NHV4
canonical
ensembl
ENSG00000139350
resolver
ensp
ENSP00000266742
resolver
ensp
ENSP00000404978
resolver
ensp
ENSP00000407964
resolver
ensp
ENSP00000411307
resolver
ensp
ENSP00000451211
resolver
genesymbol
NEDD1
resolver
hgnc
HGNC:7723
resolver
uniprot
A8K1Z3
resolver
uniprot
B0AZN0
resolver
uniprot
B4E145
resolver
uniprot
G3V3F1
resolver
uniprot
Q8NA30
resolver
uniprot_entry
A8K1Z3_HUMAN
resolver
uniprot_entry
NEDD1_HUMAN
resolver
uniprot_sec
B0AZN0
resolver
uniprot_sec
B4E145
resolver
uniprot_sec
G3V3F1
resolver
uniprot_sec
Q8NA30
resolver
amino_acid_sequence
MQENLRFASSGDDIKIWDASSMTLVDKFNPHTSPHGISSICWSSNNNFLVTASSSGDKIVVSSCKCKPVPLLELAEGQKQTCVNLNSTSMYLVSGGLNNTVNIWDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHSVTTNLSSTPFGHGSNQSVRHLKYSLFKKSLLGSVSDNGIVTLWDVNSQSPYHNFDSVHKAPASGICFSPVNELLFVTIGLDKRIILYDTSSKKLVKTLVADTPLTAVDFMPDGATLAIGSSRGKIYQYDLRMLKSPVKTISAHKTSVQCIAFQYSTVLTKSSLNKGCSNKPTTVNKRSVNVNAASGGVQNSGIVREAPATSIATVLPQPMTSAMGKGTVAVQEKAGLPRSINTDTLSKETDSGKNQDFSSFDDTGKSSLGDMFSPIRDDAVVNKGSDESIGKGDGFDFLPQLNSVFPPRKNPVTSSTSVLHSSPLNVFMGSPGKEENENRDLTAESKKIYMGKQESKDSFKQLAKLVTSGAESGNLNTSPSSNQTRNSEKFEKPENEIEAQLICEPPINGSSTPNPKIASSVTAGVASSLSEKIADSIGNNRQNAPLTSIQIRFIQNMIQETLDDFREACHRDIVNLQVEMIKQFHMQLNEMHSLLERYSVNEGLVAEIERLREENKRLRAHF
uniprot
proteins
function
FUNCTION: Required for mitosis progression. Promotes the nucleation of microtubules from the spindle. {ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:19509060}.
uniprot
proteins
mass_dalton
71966
uniprot
proteins
post_translational_modification
PTM: During mitosis, prior phosphorylation on Thr-550 by CDK1 promotes subsequent phosphorylation by PLK1 on Thr-382, Ser-397, Ser-426 and Ser-637. Phosphorylated NEDD1 can interact with gamma-tubulin for targeting the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. {ECO:0000269|PubMed:19509060}.
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19029337
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19509060
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
27137183
uniprot
proteins
sequence_length
660
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:19029337, ECO:0000269|PubMed:27137183}.
uniprot
proteins