Rabggtb
entrez
25533
canonical
uniprot
Q08603
canonical
ensembl
ENSRNOG00000009992
resolver
ensembl
ENSRNOG00055028089
resolver
ensembl
ENSRNOG00060001576
resolver
ensembl
ENSRNOG00065012661
resolver
ensp
ENSRNOP00000061541
resolver
ensp
ENSRNOP00055040007
resolver
ensp
ENSRNOP00060001571
resolver
ensp
ENSRNOP00065015891
resolver
enst
ENSRNOT00055048677
resolver
enst
ENSRNOT00060002411
resolver
enst
ENSRNOT00065020650
resolver
genesymbol
Rabggtb
resolver
genesymbol_syn
Ggtb
resolver
uniprot
A6HWN7
resolver
uniprot
Q68G48
resolver
uniprot_entry
A6HWN7_RAT
resolver
uniprot_entry
PGTB2_RAT
resolver
uniprot_sec
Q68G48
resolver
activity_regulation
ACTIVITY REGULATION: The enzymatic reaction requires the aid of a Rab escort protein (also called component A), such as CHM. {ECO:0000269|PubMed:11675392}.
uniprot
proteins
amino_acid_sequence
MGTQQKDVTIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEYLRMSGVYWGLTVMDLMGQLHRMNKEEILVFIKSCQHECGGVSASIGHDPHLLYTLSAVQILTLYDSIHVINVDKVVAYVQSLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKLDAINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDLLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWIDREKLRSFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSLLGEEQIKPVSPVFCMPEEVLQRVNVQPELVS
uniprot
proteins
ec_number
2.5.1.60
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A (By similarity). Catalytic subunit of the geranylgeranyl transferase type 3 (GGTase-3) complex (By similarity). The GGTase-3 complex geranylgeranylates and targets FBXL2 to the cellular membranes, where FBXL2 forms part of the E3 ubiquitin-protein ligase complex SCF(FBXL2) that mediates the degradation of membrane-anchored proteins (By similarity). The GGTase-3 complex geranylgeranylates Golgi v-SNARE protein YKT6 at 'Cys-194' and this prenylation is required for Golgi SNARE complex assembly (By similarity). {ECO:0000250|UniProtKB:P53611, ECO:0000269|PubMed:18399557, ECO:0000269|PubMed:18756270, ECO:0000269|PubMed:19894725, ECO:0000269|PubMed:22480322, ECO:0000269|PubMed:22963166, ECO:0000269|PubMed:8505342}.
uniprot
proteins
mass_dalton
36856
uniprot
proteins
protein_family
Protein prenyltransferase subunit beta family
uniprot
proteins
pubmed
10745007
uniprot
proteins
pubmed
11675392
uniprot
proteins
pubmed
12620235
uniprot
proteins
pubmed
18399557
uniprot
proteins
pubmed
18756270
uniprot
proteins
pubmed
19894725
uniprot
proteins
pubmed
22480322
uniprot
proteins
pubmed
22963166
uniprot
proteins
pubmed
8505342
uniprot
proteins
sequence_length
331
uniprot
proteins