Dsp
entrez
109620
canonical
uniprot
E9Q557
canonical
ensembl
ENSMUSG00000054889
resolver
ensp
ENSMUSP00000115062
resolver
ensp
ENSMUSP00000117252
resolver
enst
ENSMUST00000124830
resolver
enst
ENSMUST00000127906
resolver
genesymbol
Dsp
resolver
uniprot
E9PZW0
resolver
uniprot_entry
DESP_MOUSE
resolver
uniprot_entry
E9PZW0_MOUSE
resolver
amino_acid_sequence
MSCNGGSHPRINTLGRMTRAESGPDLRYEMTYSGGGGGGGGGGGGGTSRTFYSHSRRCTVNDQNSDGYCQTGTMSRHQNQNTIQEMLQNCSDCLMRAELIAQPELKFGEGMQLAWNRELDEYFTQANDQMEIIDGLIREMRQMGQPCDAYQKRLLQLQEQMRALYKAISVPRVRRASSKGAGGYTCQSGSGWDEFTKRLTGECLGWMRQQREEMDLMAWGVDAGSVEQHINSHRSIHNTIGDYRWQLDKIKADLREKSAIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDWSDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQWSWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQIKELEKEREKIIEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHKGDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWNQLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIEDLELHYQDFIKNSQGSEMFGDDDKRRMQSQFTDAQKHYQTLVIQLPGHPQHQTVTKTEITHLGTCQDVNHNKVIETNRENDKQETWLLMELQKIRRQMEHCEARMTLKNLLLAEQGSTHHITVKINELKSVQNDSQALAEVLNQLKDMLANFRGSEKYCYLQNEIFGLFQKLENINGVSDGYLNSLCSVRALLQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQKAQQIHSQSSQQYPLYDLDLGKFTEKVTQLTDRWQKIDKQIDFRLWDLEKQIKQLRNYRDNYQSFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVHKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMVQSPSGVILQEAADIHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLVSLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKTVEDRFDQQKNDYDQLQKARQCEKENLSWQKLESEKAIKEKEYEIERLRVLLQEEGARKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQMDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSETMQKKQRLEIELKQVIQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEYQEEAKRRWEYENELSKVRNSYDEEIISLKNQFETEINITKTTIHQLTMQKEEDTSGYRAQIDNLTRENRSLCEEVKRLKNTLAQTTENLRRVEENAQQQKATGSEMSQRKQQLEIELRQVTQMRTEESMRYKQSLDDAAKTIQDKNKEIERLKQLVDKETNERKCLEDENSKLQRVQYDLQKANNSATEAMSKLKVQEQELTRLRIDYERVSQERTVKDQDITRIQSSLKDLQLQKQKAEEELSRLKRTASDESSKRKMLEEELEAMRRSLKEQAVKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHVREKQRTQEELRRLSLDVEALRRQLVQEQENVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSDKNSTISELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKSQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKATLEAESRVKQRLECEKQQIQNDLNQWKTQYSRKEETIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSSRETQSQLESERCRLQKEIEKLRQRPYGSHRETQTEYEWTVDSSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGAIAGASASPKEKYSLVEAKRKKFITPESTVMLLEAQAATGGIIDPHRNEKLTVDNAVARDLIDFDDRQQIYTAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQLASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPITKKKVSYMQLRERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDMAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYDTFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGNSSGLGGSVNDDVFSSSRHDSVSKISTISSVRNLTIRSSSLSDPLEESSPIAAIFDTENLEKISIAEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVNQGLIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQFLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDISSYAKILTCPKTKLKISYKDAMNRSMVEDITGLRLLEAASVSSKGLPSPYNMSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYSFSSSSIGGY
uniprot
proteins
function
FUNCTION: A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Critical for cell-cell adhesion in early stage blastocysts and progression through proamniotic cavity formation (PubMed:9864371). Not required for preimplantation morphogenic process in blastocysts (PubMed:9864371). Required for keratin filament anchoring at the desmosome junction and subsequent organization of the keratin intermediate filament network within the cytoplasm (PubMed:9864371). Required for anchoring of desmosomes to the microtubule architecture, via its interaction with NIN (PubMed:17227889). Promotes microtubule-mediated GJA1/CX43 trafficking to cell membranes via its interaction with MAPRE1/EB1, thereby facilitating gap junction intracellular communication (By similarity). Plays a key role in adhesion and organization of the dermal epithelial barrier (PubMed:11222147). Critical for the maintenance of the neural tube structure following formation and organization of the neuroepithelium (PubMed:11222147). Facilitates outgrowth and repair of motor neuron fibers in regenerating axons following injury, probably by promoting recruitment of a complex containing DSP, CDH2, VIM and JUP to the outgrowth tips (PubMed:25496840). Critical for the normal formation of heart and myocardial tissue during early embryogenesis (PubMed:11222147, PubMed:16917092). Also required for development of vascular capillary structures and intact endothelial cell barriers (PubMed:11222147). Regulates profibrotic gene expression in cardiomyocytes via activation of the MAPK14/p38 MAPK signaling cascade and increase in TGFB1 protein abundance (By similarity). Maintains cardiac rhythmicity by ensuring correct cell-cell adhesion within the sinoatrial node, via stabilization of protein components of both desmosome and Gap junctions (PubMed:27097650). Involved in maintaining the protein stability and recruitment of GJA1 to functional gap junctions, via inhibition of KRAS-mediated MAPK1/MAPK3 phosphorylation of GJA1 (PubMed:29959233). Negative regulator of cell cycle progression and differentiation in keratinocytes, potentially via inhibition of MAPK and phosphoinositide-3-kinase (PI3K) signaling pathways (By similarity). Mediates the interaction between the desmosome and COP9 signalosome complex (CSN) protein complex (By similarity). As a result of this interaction, promotes keratinocyte differentiation via deneddylation of EGFR resulting in a reduction in EGFR protein stabilization and translocation away from the cell membrane (By similarity). Required for the maintenance of protein abundance of desmosome junction components DSG1, DSG2, DSC2, DSC3, PKP1, PKP2 and PKP3 (By similarity). Required for the survival and maintenance of germ cells in the gonads during embryonic development (PubMed:35119382). Binds to telomere DNA (via C-terminus) and acts to prevent telomere damage and maintain telomere length via its interaction with TRF2 (By similarity). {ECO:0000250|UniProtKB:F1LMV6, ECO:0000250|UniProtKB:P15924, ECO:0000269|PubMed:11222147, ECO:0000269|PubMed:16917092, ECO:0000269|PubMed:17227889, ECO:0000269|PubMed:25496840, ECO:0000269|PubMed:27097650, ECO:0000269|PubMed:29959233, ECO:0000269|PubMed:35119382, ECO:0000269|PubMed:9864371}.
uniprot
proteins
mass_dalton
332912
uniprot
proteins
mutagenesis
MUTAGEN 102; /note="Q->R: Embryonically lethal, embryos show severely reduced heart wall thickness and ventricular dilation at 13.5 dpc."; /evidence="ECO:0000269|PubMed:16917092"; MUTAGEN 2845; /note="R->H: Decreases GSK3B-mediated phosphorylation and reduces trafficking to desmosome cell-cell junctions. No effect on protein abundance. Thickening of the heart wall tissues with systemic dysfunction and structural changes to both ventricles accompanied by fibrotic tissue formation and myocyte apoptosis from 6 months of age. Decrease in colocalization with Des at Z-disks and marked changes in intercalated disks with widening gaps between adjacent anchoring sarcomeres, suggesting dysfunctional adherens junctions and desmosomes."; /evidence="ECO:0000269|PubMed:16917092, ECO:0000269|PubMed:25733715
uniprot
proteins
post_translational_modification
PTM: Methylation by PRMT1 promotes GSK3B-mediated phosphorylation cascade of multiple serine residues at the C-terminus resulting in trafficking to desmosome cell-cell junctions. {ECO:0000250|UniProtKB:P15924}.; PTM: Phosphorylation by GSK3B occurs sequentially from Ser-2860 along multiple serine residue at the C-terminus. Hyperphosphorylation by GSK3B results in recruitment to desmosome cell-cell junction and promotion of intercellular adhesion (By similarity). Phosphorylation at Ser-2860 increases association with intermediate filament cytokeratin, potentially facilitating interaction between desmosome junctions and intermediate filament architecture. {ECO:0000250|UniProtKB:P15924}.
uniprot
proteins
protein_family
Plakin or cytolinker family
uniprot
proteins
pubmed
11222147
uniprot
proteins
pubmed
12494996
uniprot
proteins
pubmed
15479741
uniprot
proteins
pubmed
16917092
uniprot
proteins
pubmed
17227889
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18079750
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21285247
uniprot
proteins
pubmed
22515648
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
25496840
uniprot
proteins
pubmed
25733715
uniprot
proteins
pubmed
26403541
uniprot
proteins
pubmed
27033150
uniprot
proteins
pubmed
27097650
uniprot
proteins
pubmed
27375112
uniprot
proteins
pubmed
28507225
uniprot
proteins
pubmed
29959233
uniprot
proteins
pubmed
30389720
uniprot
proteins
pubmed
34905516
uniprot
proteins
pubmed
35119382
uniprot
proteins
pubmed
38395410
uniprot
proteins
pubmed
9864371
uniprot
proteins
sequence_length
2883
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, axon {ECO:0000269|PubMed:25496840}. Cell junction, desmosome {ECO:0000269|PubMed:12494996, ECO:0000269|PubMed:15479741, ECO:0000269|PubMed:18079750, ECO:0000269|PubMed:22515648, ECO:0000269|PubMed:25733715, ECO:0000269|PubMed:27033150, ECO:0000269|PubMed:27097650, ECO:0000269|PubMed:27375112, ECO:0000269|PubMed:28507225, ECO:0000269|PubMed:38395410}. Cell membrane {ECO:0000269|PubMed:21285247, ECO:0000269|PubMed:22515648, ECO:0000269|PubMed:26403541, ECO:0000269|PubMed:30389720, ECO:0000269|PubMed:9864371}. Cytoplasm {ECO:0000269|PubMed:25733715, ECO:0000269|PubMed:27033150, ECO:0000269|PubMed:27375112, ECO:0000269|PubMed:28507225, ECO:0000269|PubMed:30389720}. Nucleus {ECO:0000250|UniProtKB:P15924}. Note=Localizes to desmosome precursor particles in the cytoplasm (By similarity). Localizes to the cytoplasm in undifferentiated keratinocytes however becomes localizes to both lateral and tricellular cell-cell contacts as differentiation progresses and as epithelial sheet formation completes (PubMed:27375112). Localizes to the interface of the cortical keratin network and endodermal cell periphery in developing embryos (PubMed:9864371). {ECO:0000250|UniProtKB:P15924, ECO:0000269|PubMed:27375112, ECO:0000269|PubMed:9864371}.
uniprot
proteins