ATP11B
entrez
23200
canonical
uniprot
Q9Y2G3
canonical
ensembl
ENSG00000058063
resolver
ensp
ENSP00000321195
resolver
ensp
ENSP00000418421
resolver
ensp
ENSP00000784439
resolver
enst
ENST00000323116
resolver
genesymbol
ATP11B
resolver
genesymbol_syn
ATPIF
resolver
genesymbol_syn
ATPIR
resolver
genesymbol_syn
KIAA0956
resolver
hgnc
HGNC:13553
resolver
uniprot
B4DKX1
resolver
uniprot
B4E3T1
resolver
uniprot
Q96FN1
resolver
uniprot
Q9UKK7
resolver
uniprot_entry
AT11B_HUMAN
resolver
uniprot_entry
B4DKX1_HUMAN
resolver
uniprot_entry
B4E3T1_HUMAN
resolver
uniprot_sec
Q96FN1
resolver
uniprot_sec
Q9UKK7
resolver
activity_regulation
ACTIVITY REGULATION: The ATPase activity is up-regulated by aminophospholipids PS and PE. {ECO:0000269|PubMed:30018401}.
uniprot
proteins
amino_acid_sequence
MWRWIRQQLGFDPPHQSDTRTIYVANRFPQNGLYTPQKFIDNRIISSKYTVWNFVPKNLFEQFRRVANFYFLIIFLVQLMIDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHNSDNEVNGAPVYVVRSGGLVKTRSKNIRVGDIVRIAKDEIFPADLVLLSSDRLDGSCHVTTASLDGETNLKTHVAVPETALLQTVANLDTLVAVIECQQPEADLYRFMGRMIITQQMEEIVRPLGPESLLLRGARLKNTKEIFGVAVYTGMETKMALNYKSKSQKRSAVEKSMNTFLIIYLVILISEAVISTILKYTWQAEEKWDEPWYNQKTEHQRNSSKILRFISDFLAFLVLYNFIIPISLYVTVEMQKFLGSFFIGWDLDLYHEESDQKAQVNTSDLNEELGQVEYVFTDKTGTLTENEMQFRECSINGMKYQEINGRLVPEGPTPDSSEGNLSYLSSLSHLNNLSHLTTSSSFRTSPENETELIKEHDLFFKAVSLCHTVQISNVQTDCTGDGPWQSNLAPSQLEYYASSPDEKALVEAAARIGIVFIGNSEETMEVKTLGKLERYKLLHILEFDSDRRRMSVIVQAPSGEKLLFAKGAESSILPKCIGGEIEKTRIHVDEFALKGLRTLCIAYRKFTSKEYEEIDKRIFEARTALQQREEKLAAVFQFIEKDLILLGATAVEDRLQDKVRETIEALRMAGIKVWVLTGDKHETAVSVSLSCGHFHRTMNILELINQKSDSECAEQLRQLARRITEDHVIQHGLVVDGTSLSLALREHEKLFMEVCRNCSAVLCCRMAPLQKAKVIRLIKISPEKPITLAVGDGANDVSMIQEAHVGIGIMGKEGRQAARNSDYAIARFKFLSKLLFVHGHFYYIRIATLVQYFFYKNVCFITPQFLYQFYCLFSQQTLYDSVYLTLYNICFTSLPILIYSLLEQHVDPHVLQNKPTLYRDISKNRLLSIKTFLYWTILGFSHAFIFFFGSYLLIGKDTSLLGNGQMFGNWTFGTLVFTVMVITVTVKMALETHFWTWINHLVTWGSIIFYFVFSLFYGGILWPFLGSQNMYFVFIQLLSSGSAWFAIILMVVTCLFLDIIKKVFDRHLHPTSTEKAQLTETNAGIKCLDSMCCFPEGEAACASVGRMLERVIGRCSPTHISRSWSASDPFYTNDRSILTLSTMDSSTC
uniprot
proteins
ec_number
7.6.2.1
uniprot
proteins
function
FUNCTION: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of intracellular membranes (PubMed:30018401). May contribute to the maintenance of membrane lipid asymmetry in endosome compartment (PubMed:30018401). {ECO:0000269|PubMed:30018401}.
uniprot
proteins
mass_dalton
134190
uniprot
proteins
mutagenesis
MUTAGEN 180; /note="E->Q: Impairs ATPase activity."; /evidence="ECO:0000269|PubMed:30018401
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type IV subfamily
uniprot
proteins
pubmed
10231032
uniprot
proteins
pubmed
11015572
uniprot
proteins
pubmed
11790799
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21914794
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23585472
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
30018401
uniprot
proteins
sequence_length
1177
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000269|PubMed:21914794}; Multi-pass membrane protein. Early endosome {ECO:0000269|PubMed:23585472}. Endoplasmic reticulum {ECO:0000269|PubMed:21914794}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:23585472}. Note=Exit from the endoplasmic reticulum requires the presence of CDC50A, but not CDC50B (PubMed:21914794). In the presence of CDC50A, mainly located in recycling endosomes (PubMed:21914794). {ECO:0000269|PubMed:21914794}.
uniprot
proteins
transmembrane_region
TRANSMEM 56..77; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 83..104; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 290..311; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 342..359; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 877..898; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 911..930; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 961..982; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 998..1020; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1026..1047; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1066..1090; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins