PDIA2
entrez
64714
canonical
uniprot
Q13087
canonical
ensembl
ENSG00000185615
resolver
ensp
ENSP00000219406
resolver
genesymbol
PDIA2
resolver
genesymbol_syn
PDIP
resolver
hgnc
HGNC:14180
resolver
uniprot
A6ZJ64
resolver
uniprot
B4DI27
resolver
uniprot
Q2WGM4
resolver
uniprot
Q4TT67
resolver
uniprot
Q6B010
resolver
uniprot
Q96KJ6
resolver
uniprot
Q9BW95
resolver
uniprot_entry
PDIA2_HUMAN
resolver
uniprot_sec
A6ZJ64
resolver
uniprot_sec
B4DI27
resolver
uniprot_sec
Q2WGM4
resolver
uniprot_sec
Q4TT67
resolver
uniprot_sec
Q6B010
resolver
uniprot_sec
Q96KJ6
resolver
uniprot_sec
Q9BW95
resolver
amino_acid_sequence
MSRQLLPVLLLLLLRASCPWGQEQGARSPSEEPPEEEIPKEDGILVLSRHTLGLALREHPALLVEFYAPWCGHCQALAPEYSKAAAVLAAESMVVTLAKVDGPAQRELAEEFGVTEYPTLKFFRNGNRTHPEEYTGPRDAEGIAEWLRRRVGPSAMRLEDEAAAQALIGGRDLVVIGFFQDLQDEDVATFLALAQDALDMTFGLTDRPRLFQQFGLTKDTVVLFKKFDEGRADFPVDEELGLDLGDLSRFLVTHSMRLVTEFNSQTSAKIFAARILNHLLLFVNQTLAAHRELLAGFGEAAPRFRGQVLFVVVDVAADNEHVLQYFGLKAEAAPTLRLVNLETTKKYAPVDGGPVTAASITAFCHAVLNGQVKPYLLSQEIPPDWDQRPVKTLVGKNFEQVAFDETKNVFVKFYAPWCTHCKEMAPAWEALAEKYQDHEDIIIAELDATANELDAFAVHGFPTLKYFPAGPGRKVIEYKSTRDLETFSKFLDNGGVLPTEEPPEEPAAPFPEPPANSTMGSKEEL
uniprot
proteins
ec_number
5.3.4.1
uniprot
proteins
function
FUNCTION: Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins. {ECO:0000269|PubMed:19150607, ECO:0000269|PubMed:19429457}.
uniprot
proteins
mass_dalton
58206
uniprot
proteins
mutagenesis
MUTAGEN 18; /note="C->A: Impairs interchain disulfide bridge formation."; /evidence="ECO:0000269|PubMed:19150607"; MUTAGEN 284; /note="N->Q: Increases formation of a highly stable disulfide-bonded PDIA2 dimer."; /evidence="ECO:0000269|PubMed:23167757"; MUTAGEN 364; /note="C->A: No effect on interchain disulfide bridge formation."; /evidence="ECO:0000269|PubMed:19150607
uniprot
proteins
post_translational_modification
PTM: The disulfide-linked homodimer exhibits an enhanced chaperone activity.; PTM: Glycosylated. {ECO:0000269|PubMed:23167757, ECO:0000269|PubMed:9115635}.
uniprot
proteins
protein_family
Protein disulfide isomerase family
uniprot
proteins
pubmed
11157797
uniprot
proteins
pubmed
12475965
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
19150607
uniprot
proteins
pubmed
19429457
uniprot
proteins
pubmed
23167757
uniprot
proteins
pubmed
8561901
uniprot
proteins
pubmed
9115635
uniprot
proteins
sequence_length
525
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}.
uniprot
proteins