Spry4
entrez
24066
canonical
uniprot
Q9WTP2
canonical
ensembl
ENSMUSG00000024427
resolver
ensp
ENSMUSP00000025295
resolver
enst
ENSMUST00000025295
resolver
genesymbol
Spry4
resolver
uniprot
Q543R1
resolver
uniprot
Q9QXV7
resolver
uniprot_entry
SPY4_MOUSE
resolver
uniprot_sec
Q543R1
resolver
uniprot_sec
Q9QXV7
resolver
amino_acid_sequence
MEPPVPQSSVPVNPSSVMVQPLLDSRAPHSRLQHPLTILPIDQMKTSHVENDYIDNPSLAPATGPKRPRGGPPELAPTPARCDQDITHHWISFSGRPSSVSSSSSTSSDQRLLDHMAPPPVAEQASPRAVRLQPKVVHCKPLDLKGPTAPPELDKHFLLCEACGKCKCKECASPRTLPSCWVCNQECLCSAQTLVNYGTCMCLVQGIFYHCTNEDDEGSCADHPCSCSGSNCCARWSFMGALSVVLPCLLCYLPATGCVKLAQRGYDRLRRPGCRCKHTNSVICKAASGDTKTSRSDKPF
uniprot
proteins
function
FUNCTION: Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Probably impairs the formation of GTP-Ras (By similarity). Inhibits Ras-independent, but not Ras-dependent, activation of RAF1 (By similarity). Represses integrin-mediated cell spreading via inhibition of TESK1-mediated phosphorylation of cofilin (By similarity). {ECO:0000250|UniProtKB:Q9C004}.
uniprot
proteins
mass_dalton
32523
uniprot
proteins
protein_family
Sprouty family
uniprot
proteins
pubmed
10330503
uniprot
proteins
pubmed
10498682
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16877379
uniprot
proteins
pubmed
17974561
uniprot
proteins
sequence_length
300
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9C004}. Cell projection, ruffle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Found in the cytoplasm in unstimulated cells but is translocated to the membrane ruffles in cells stimulated with EGF (epidermal growth factor). Colocalizes with TESK1 in vesicular spots in the cytoplasm (By similarity). {ECO:0000250|UniProtKB:Q9C004}.
uniprot
proteins