SLC16A3
entrez
9123
canonical
uniprot
O15427
canonical
ensembl
ENSG00000141526
resolver
ensp
ENSP00000376150
resolver
ensp
ENSP00000376152
resolver
ensp
ENSP00000462405
resolver
ensp
ENSP00000463978
resolver
ensp
ENSP00000464112
resolver
ensp
ENSP00000464625
resolver
ensp
ENSP00000482013
resolver
ensp
ENSP00000483212
resolver
ensp
ENSP00000547865
resolver
ensp
ENSP00000547866
resolver
ensp
ENSP00000547867
resolver
ensp
ENSP00000547868
resolver
ensp
ENSP00000547869
resolver
ensp
ENSP00000547870
resolver
ensp
ENSP00000547871
resolver
ensp
ENSP00000618172
resolver
enst
ENST00000392339
resolver
enst
ENST00000392341
resolver
enst
ENST00000580189
resolver
enst
ENST00000581287
resolver
enst
ENST00000582743
resolver
enst
ENST00000584689
resolver
enst
ENST00000617373
resolver
enst
ENST00000619321
resolver
enst
ENST00000877806
resolver
enst
ENST00000877807
resolver
enst
ENST00000877808
resolver
enst
ENST00000877809
resolver
enst
ENST00000877810
resolver
enst
ENST00000877811
resolver
enst
ENST00000877812
resolver
enst
ENST00000948113
resolver
genesymbol
SLC16A3
resolver
genesymbol_syn
MCT3
resolver
genesymbol_syn
MCT4
resolver
hgnc
HGNC:10924
resolver
uniprot
B3KXG8
resolver
uniprot
Q2M1P8
resolver
uniprot_entry
MOT4_HUMAN
resolver
uniprot_sec
B3KXG8
resolver
uniprot_sec
Q2M1P8
resolver
amino_acid_sequence
MGGAVVDEGPTGVKAPDGGWGWAVLFGCFVITGFSYAFPKAVSVFFKELIQEFGIGYSDTAWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGMVAASFCRSIIQVYLTTGVITGLGLALNFQPSLIMLNRYFSKRRPMANGLAAAGSPVFLCALSPLGQLLQDRYGWRGGFLILGGLLLNCCVCAALMRPLVVTAQPGSGPPRPSRRLLDLSVFRDRGFVLYAVAASVMVLGLFVPPVFVVSYAKDLGVPDTKAAFLLTILGFIDIFARPAAGFVAGLGKVRPYSVYLFSFSMFFNGLADLAGSTAGDYGGLVVFCIFFGISYGMVGALQFEVLMAIVGTHKFSSAIGLVLLMEAVAVLVGPPSGGKLLDATHVYMYVFILAGAEVLTSSLILLLGNFFCIRKKPKEPQPEVAAAEEEKLHKPPADSGVDLREVEHFLKAEPEKNGEVVHTPETSV
uniprot
proteins
function
FUNCTION: Proton-dependent transporter of monocarboxylates such as L-lactate and pyruvate (PubMed:11101640, PubMed:23935841, PubMed:31719150). Plays a predominant role in L-lactate efflux from highly glycolytic cells (By similarity). {ECO:0000250|UniProtKB:O35910, ECO:0000269|PubMed:11101640, ECO:0000269|PubMed:23935841, ECO:0000269|PubMed:31719150}.
uniprot
proteins
mass_dalton
49469
uniprot
proteins
mutagenesis
MUTAGEN 198; /note="R->Q: Does not affect lactate transmembrane transporter activity."; /evidence="ECO:0000269|PubMed:23935841"; MUTAGEN 278; /note="R->Q,K: Abolishes lactate transmembrane transporter activity. Does not affect cell membrane localization."; /evidence="ECO:0000269|PubMed:23935841"; MUTAGEN 425; /note="E->A: Affects subcellular localization leading to apical localization. Affects subcellular localization leading to apical localization; when associated with A-426 and A-427."; /evidence="ECO:0000269|PubMed:21199217"; MUTAGEN 426; /note="E->A: Leads to a nonpolar expression pattern. Affects subcellular localization leading to apical localization; when associated with A-425 and A-427."; /evidence="ECO:0000269|PubMed:21199217"; MUTAGEN 427; /note="E->A: Affects subcellular localization leading to apical localization. Affects subcellular localization leading to apical localization; when associated with A-425 and A-426."; /evidence="ECO:0000269|PubMed:21199217"; MUTAGEN 432; /note="P->A: Does not affect basolateral plasma membrane localization. Intracellular accumulation. Affects subcellular localization leading to apical localization; when associated with A-433."; /evidence="ECO:0000269|PubMed:21199217"; MUTAGEN 433; /note="P->A: Does not affect basolateral plasma membrane localization. Intracellular accumulation. Affects subcellular localization leading to apical localization; when associated with A-432."; /evidence="ECO:0000269|PubMed:21199217
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Monocarboxylate porter (TC 2.A.1.13) family
uniprot
proteins
pubmed
10921872
uniprot
proteins
pubmed
11101640
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15505343
uniprot
proteins
pubmed
16452478
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21199217
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23935841
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
31719150
uniprot
proteins
pubmed
9425115
uniprot
proteins
sequence_length
465
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10921872, ECO:0000269|PubMed:11101640, ECO:0000269|PubMed:15505343, ECO:0000269|PubMed:23935841}; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000269|PubMed:21199217}; Multi-pass membrane protein {ECO:0000255}. Note=Plasma membrane localization is dependent upon the BSG/MCT4 interaction (PubMed:10921872). Basolateral sorting signals (BLSS) in C-terminal cytoplasmic tail ensure its basolateral expression in polarised epithelial cells (PubMed:21199217). {ECO:0000269|PubMed:10921872, ECO:0000269|PubMed:21199217}.
uniprot
proteins
transmembrane_region
TRANSMEM 18..38; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 62..82; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 85..105; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 110..130; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 150..170; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 180..200; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 228..248; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 265..285; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 295..315; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 318..338; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 352..372; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 385..405; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins