Clptm1l
entrez
218335
canonical
uniprot
Q8BXA5
canonical
ensembl
ENSMUSG00000021610
resolver
ensp
ENSMUSP00000022102
resolver
enst
ENSMUST00000022102
resolver
genesymbol
Clptm1l
resolver
uniprot
Q3U176
resolver
uniprot
Q8C053
resolver
uniprot
Q8R0P2
resolver
uniprot_entry
CLP1L_MOUSE
resolver
uniprot_sec
Q3U176
resolver
uniprot_sec
Q8C053
resolver
uniprot_sec
Q8R0P2
resolver
amino_acid_sequence
MWSGRSSFTSLVVGVFLVYVVHTCWVMYGIVYTRPCSGDSNCIQPYLALRPKLQLSVYTTTRSSLGAENNVDLILNVEDFDVDSKFERTVNVSVPKKTRNNGTLYAYIFLHHAGILPWQDGKQVHVVSTLTTYMIPKPEEINLLTGESATQQQIEAEKKPSNALDEPVSHWRPRLTLNVMVDDFVFDGSSLPADVHRYMKMIQLGKTVHYLPILFIDQLSNRVKDLMVINRSTTELPLTVSYDKISLGRLRFWIHMQDAVYSLQQFGFSEKDADELKGIFVDTNLYLLALTFFVAAFHLLFDFLAFKSDISFWKKKKSMIGMSTKAVLWRCFSTVVIFLFLLDEQTSLLVLIPAGVGAAIELWKVKKALKITVAWRGLRPVFQFGTHSESERKTEKYDAQAMKYLSYLLYPLCVGGAVYSLLNIKYKSWYSWLINSFVNGVYAFGFLFMLPQLFVNYKMKSVAHLPWKAFTYKAFNTFIDDVFAFIITMPTSHRLACFRDDVVFLVYLYQRWLYPVDKSRVNEFGESYEEQPKRKPHPD
uniprot
proteins
function
FUNCTION: Scramblase that mediates the translocation of glucosaminylphosphatidylinositol (alpha-D-GlcN-(1-6)-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol, GlcN-PI) across the endoplasmic reticulum (ER) membrane, from the cytosolic leaflet to the luminal leaflet of the ER membrane, where it participates in the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is a lipid glycoconjugate involved in post-translational modification of proteins. Can also translocate 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) (phosphatidylinositol or PI), as well as several other phospholipids (1,2-diacyl-sn-glycero-3-phosphocholine, 1,2-diacyl-sn-glycero-3-phosphoethanolamine), and N-acetylglucosaminylphosphatidylinositol (GlcNAc-PI) in vitro. {ECO:0000250|UniProtKB:Q96KA5}.
uniprot
proteins
mass_dalton
62183
uniprot
proteins
protein_family
CLPTM1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
539
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 11..31; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 286..306; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 326..342; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 404..424; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 430..450; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins