CYRIB
entrez
51571
canonical
uniprot
Q9NUQ9
canonical
ensembl
ENSG00000153310
resolver
ensp
ENSP00000384880
resolver
ensp
ENSP00000428117
resolver
ensp
ENSP00000429078
resolver
ensp
ENSP00000429150
resolver
ensp
ENSP00000429499
resolver
ensp
ENSP00000429802
resolver
ensp
ENSP00000429978
resolver
ensp
ENSP00000430433
resolver
ensp
ENSP00000430674
resolver
ensp
ENSP00000511587
resolver
ensp
ENSP00000514126
resolver
ensp
ENSP00000515265
resolver
ensp
ENSP00000567435
resolver
ensp
ENSP00000567436
resolver
ensp
ENSP00000567438
resolver
ensp
ENSP00000567441
resolver
ensp
ENSP00000567443
resolver
ensp
ENSP00000567444
resolver
ensp
ENSP00000567445
resolver
ensp
ENSP00000567447
resolver
ensp
ENSP00000567448
resolver
ensp
ENSP00000567449
resolver
ensp
ENSP00000567456
resolver
ensp
ENSP00000567458
resolver
ensp
ENSP00000567463
resolver
ensp
ENSP00000602417
resolver
ensp
ENSP00000602419
resolver
ensp
ENSP00000602427
resolver
ensp
ENSP00000602430
resolver
ensp
ENSP00000624143
resolver
ensp
ENSP00000624147
resolver
ensp
ENSP00000624151
resolver
enst
ENST00000699094
resolver
enst
ENST00000703342
resolver
genesymbol
CYRIB
resolver
genesymbol_syn
CYRI
resolver
genesymbol_syn
FAM49B
resolver
hgnc
HGNC:25216
resolver
uniprot
A0A8V8TMP7
resolver
uniprot
Q96AZ5
resolver
uniprot
Q9NW21
resolver
uniprot
Q9NZE7
resolver
uniprot_entry
A0A8V8TMP7_HUMAN
resolver
uniprot_entry
CYRIB_HUMAN
resolver
uniprot_sec
Q96AZ5
resolver
uniprot_sec
Q9NW21
resolver
uniprot_sec
Q9NZE7
resolver
amino_acid_sequence
MGNLLKVLTCTDLEQGPNFFLDFENAQPTESEKEIYNQVNVVLKDAEGILEDLQSYRGAGHEIREAIQHPADEKLQEKAWGAVVPLVGKLKKFYEFSQRLEAALRGLLGALTSTPYSPTQHLEREQALAKQFAEILHFTLRFDELKMTNPAIQNDFSYYRRTLSRMRINNVPAEGENEVNNELANRMSLFYAEATPMLKTLSDATTKFVSENKNLPIENTTDCLSTMASVCRVMLETPEYRSRFTNEETVSFCLRVMVGVIILYDHVHPVGAFAKTSKIDMKGCIKVLKDQPPNSVEGLLNALRYTTKHLNDETTSKQIKSMLQ
uniprot
proteins
function
FUNCTION: Negatively regulates RAC1 signaling and RAC1-driven cytoskeletal remodeling (PubMed:30250061, PubMed:31285585). Regulates chemotaxis, cell migration and epithelial polarization by controlling the polarity, plasticity, duration and extent of protrusions. Limits Rac1 mediated activation of the Scar/WAVE complex, focuses protrusion signals and regulates pseudopod complexity by inhibiting Scar/WAVE-induced actin polymerization (PubMed:30250061). Protects against Salmonella bacterial infection. Attenuates processes such as macropinocytosis, phagocytosis and cell migration and restrict sopE-mediated bacterial entry (PubMed:31285585). Also restricts infection mediated by Mycobacterium tuberculosis and Listeria monocytogenes (By similarity). Involved in the regulation of mitochondrial dynamics and oxidative stress (PubMed:29059164). {ECO:0000250|UniProtKB:Q921M7, ECO:0000269|PubMed:29059164, ECO:0000269|PubMed:30250061, ECO:0000269|PubMed:31285585}.
uniprot
proteins
mass_dalton
36748
uniprot
proteins
mutagenesis
MUTAGEN 150; /note="P->D: No effect on interaction with RAC1. Almost abolishes interaction with RAC1; when associated with D-161."; /evidence="ECO:0000269|PubMed:31285585"; MUTAGEN 160..161; /note="RR->DD: Abolishes interaction with RAC1."; /evidence="ECO:0000269|PubMed:30250061"; MUTAGEN 161; /note="R->D: Strongly decreases interaction with RAC1. Almost abolishes interaction with RAC1; when associated with D-150."; /evidence="ECO:0000269|PubMed:31285585
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated at Lys-74 upon Salmonella bacterial infection. {ECO:0000269|PubMed:31285585}.
uniprot
proteins
protein_family
CYRI family
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25255805
uniprot
proteins
pubmed
29059164
uniprot
proteins
pubmed
30250061
uniprot
proteins
pubmed
31285585
uniprot
proteins
sequence_length
324
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Mitochondrion {ECO:0000269|PubMed:29059164}.
uniprot
proteins