Spsb3
entrez
79043
canonical
uniprot
Q571F5
canonical
ensembl
ENSMUSG00000024160
resolver
ensp
ENSMUSP00000024976
resolver
ensp
ENSMUSP00000068567
resolver
ensp
ENSMUSP00000112380
resolver
ensp
ENSMUSP00000112492
resolver
ensp
ENSMUSP00000112589
resolver
ensp
ENSMUSP00000321932
resolver
ensp
ENSMUSP00000321941
resolver
ensp
ENSMUSP00000321943
resolver
ensp
ENSMUSP00000354550
resolver
enst
ENSMUST00000119829
resolver
genesymbol
Spsb3
resolver
genesymbol_syn
Kiaa4204
resolver
genesymbol_syn
Ssb3
resolver
genesymbol_syn
Tce1
resolver
uniprot
D3YW96
resolver
uniprot
Q3U0T8
resolver
uniprot
Q6GQX9
resolver
uniprot
Q8C6A9
resolver
uniprot
Q8R4S9
resolver
uniprot
Q9D7E0
resolver
uniprot_entry
D3YW96_MOUSE
resolver
uniprot_entry
SPSB3_MOUSE
resolver
uniprot_sec
Q3U0T8
resolver
uniprot_sec
Q6GQX9
resolver
uniprot_sec
Q8C6A9
resolver
uniprot_sec
Q8R4S9
resolver
uniprot_sec
Q9D7E0
resolver
amino_acid_sequence
MARRTRSSRAWHFVLSAARRDTDARAVALAGSSNWGYDSDGQHSDSDSDPEYSSLPPSIPSAVPVTGESFCDCEGQNEATFCNSLHTAHRGKDCRCGEEDEDFDWVWDDLNKSSATLLSCDNRKVSFHMEYSCGTAAIRGTKELGDGQHFWEIKMTSPVYGTDMMVGIGTSDVDLDKYHHTFCSLLGRDEDSWGLSYTGLLHHKGDKTSFSSRFGQGSIIGVHLDTWHGTLTFFKNRKCIGVAATRLQNRRFYPMVCSTAAKSSMKVIRSCASSTSLQYLCCYRLRQLRPNSGDTLEGLPLPPGLKQVLHNKLGWVLSMNCNHWKSPVPPPGTATPGAESLETRPCQRKRCRRS
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CGAS and SNAI1. The ECS(SPSB3) complex catalyzes 'Lys-48'-linked ubiquitination of nuclear CGAS in cycling cells, leading to its degradation. Recognizes and binds nucleosome-bound CGAS: ubiquitination and degradation of nuclear CGAS during G1 and G2 phases is required to promote low intranuclear CGAS abundance before the next mitotic cycle. The ECS(SPSB3) complex also mediates ubiquitination and degradation of phosphorylated SNAI1. {ECO:0000250|UniProtKB:Q6PJ21}.
uniprot
proteins
mass_dalton
39321
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q6PJ21}.
uniprot
proteins
protein_family
SPSB family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
354
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6PJ21}. Note=Nuclear SPSB3 levels increase during interphase. {ECO:0000250|UniProtKB:Q6PJ21}.
uniprot
proteins