Tshr
entrez
22095
canonical
uniprot
P47750
canonical
ensembl
ENSMUSG00000020963
resolver
ensp
ENSMUSP00000021343
resolver
ensp
ENSMUSP00000021346
resolver
enst
ENSMUST00000021343
resolver
enst
ENSMUST00000021346
resolver
genesymbol
Tshr
resolver
uniprot
F6X2Z0
resolver
uniprot
Q562E4
resolver
uniprot
Q78U67
resolver
uniprot
Q9D697
resolver
uniprot_entry
F6X2Z0_MOUSE
resolver
uniprot_entry
Q78U67_MOUSE
resolver
uniprot_entry
TSHR_MOUSE
resolver
uniprot_sec
Q562E4
resolver
uniprot_sec
Q9D697
resolver
amino_acid_sequence
MRPGSLLLLVLLLALSRSLRGKECASPPCECHQEDDFRVTCKELHRIPSLPPSTQTLKLIETHLKTIPSLAFSSLPNISRIYLSIDATLQRLEPHSFYNLSKMTHIEIRNTRSLTYIDPDALTELPLLKFLGIFNTGLRIFPDLTKIYSTDIFFILEITDNPYMTSVPENAFQGLCNETLTLKLYNNGFTSVQGHAFNGTKLDAVYLNKNKYLTAIDNDAFGGVYSGPTLLDVSSTSVTALPSKGLEHLKELIAKDTWTLKKLPLSLSFLHLTRADLSYPSHCCAFKNQKKIRGILESLMCNESSIRNLRQRKSVNILRGPIYQEYEEDPGDNSVGYKQNSKFQESPSNSHYYVFFEEQEDEVVGFGQELKNPQEETLQAFESHYDYTVCGDNEDMVCTPKSDEFNPCEDIMGYRFLRIVVWFVSLLALLGNIFVLLILLTSHYKLTVPRFLMCNLAFADFCMGVYLLLIASVDLYTHSEYYNHAIDWQTGPGCNTAGFFTVFASELSVYTLTVITLERWYAITFAMRLDRKIRLRHAYTIMAGGWVSCFLLALLPMVGISSYAKVSICLPMDTDTPLALAYIVLVLLLNVVAFVVVCSCYVKIYITVRNPQYNPRDKDTKIAKRMAVLIFTDFMCMAPISFYALSALMNKPLITVTNSKILLVLFYPLNSCANPFLYAIFTKAFQRDVFILLSKFGICKRQAQAYQGQRVCPNNSTGIQIQKIPQDTRQSLPNMQDTYELLGNSQLAPKLQGQISEEYKQTAL
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Tshr are the cause of hyt/hyt hypothyroidism, an autosomal recessive, fetal-onset, severe hypothyroidism related to TSH hyporesponsiveness and associated with elevated TSH. {ECO:0000305|PubMed:8170469}.
uniprot
proteins
function
FUNCTION: Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. TSHR is coupled to G(s) proteins and mediates the activation of adenylate cyclase. This leads to the generation of cyclic adenosine monophosphate (cAMP), which in turn activates protein kinase A (PKA). PKA subsequently phosphorylates downstream targets involved in thyroid hormone biosynthesis and secretion, including thyroid peroxidase (TPO) and the sodium/iodide symporter (NIS) (PubMed:12432094). Additionally, plays a central role in controlling thyroid cell metabolism (By similarity). {ECO:0000250|UniProtKB:P16473, ECO:0000250|UniProtKB:P21463, ECO:0000269|PubMed:12432094}.
uniprot
proteins
mass_dalton
86583
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:P16473}.; PTM: Sulfated. Sulfation on Tyr-385 plays a role in thyrotropin receptor binding and activation. {ECO:0000250|UniProtKB:P16473}.
uniprot
proteins
protein_family
FSH/LSH/TSH subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12432094
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
8170469
uniprot
proteins
sequence_length
764
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P16473}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P16473}. Basolateral cell membrane {ECO:0000250|UniProtKB:P16473}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P16473}.
uniprot
proteins
transmembrane_region
TRANSMEM 415..440; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P16473"; TRANSMEM 451..473; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P16473"; TRANSMEM 493..517; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P16473"; TRANSMEM 538..558; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P16473"; TRANSMEM 577..602; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P16473"; TRANSMEM 626..649; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P16473"; TRANSMEM 658..681; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P16473
uniprot
proteins