Ppp1r10
entrez
65045
canonical
uniprot
O55000
canonical
ensembl
ENSRNOG00000059268
resolver
ensembl
ENSRNOG00065025983
resolver
ensp
ENSRNOP00000098194
resolver
ensp
ENSRNOP00065036692
resolver
enst
ENSRNOT00000120552
resolver
enst
ENSRNOT00065044797
resolver
genesymbol
Ppp1r10
resolver
genesymbol_syn
Pnuts
resolver
uniprot
A4QN30
resolver
uniprot
Q6MG09
resolver
uniprot_entry
A4QN30_RAT
resolver
uniprot_entry
PP1RA_RAT
resolver
uniprot_sec
Q6MG09
resolver
amino_acid_sequence
MGSGPIDPKELLKGLDSFLTRDGEVKSVDGIAKIFSLMKEARKMVSRCTYLNIILQTRAPEVLVKFIDVGGYKLLNSWLTYSKTTNNIPLLQQILLTLQHLPLTVDHLKQNNTAKLVKQLSKSSEDEELRKLASVLVSDWMAVIRSQSSTQPAEKDKKKRKEEGKSRTTLPERPLTEVKAETRAEEAPEKKKEKPKSLRTTAPSHAKFRSTGLELDTPSLVPVKKNSSTVVVSDKYNLKPIPLKRQSATAAPGDAAPPAEKKYKPLNTTPNTTKEIKVKIIPPQPMEGLGFLDALNSAPVPGIKIKKKKKVLSPTAAKPSPFEGKTSTEPSTAKPSSPEPAAPAEPMDTDRPGTPVPAVEVPELMDAASSEPGALDAKPVESPGDPNQLTRKGRKRKTVTWPEEGKLREYFYFELDETERVNVNKIKDFGEAAKREILSDRHAFETARRLSHDNMEEKVPWVCPRPLVLPSPLVIPGSNSQERYIQAEREKGILQELFLNKESPHEPDPEPYEPIPPKLIPLDEECAMDETPYVETLEPGGSGGSPDGAGGSKLPPVLANLMGSMGAGKSPQGPGGGGINVQEILTSIMGSPNNHPSEELLKQPDYSDKLKQMLVPHGLLGPGPVANGFPPGGPGGPKGMQHFPPGPGGPMPGPHGGPGGPVGPRLLGPPPPSRGGDPFWDGPGDPMRGGPMRGGPGPGPGPYHRGRGGRGGNEPPPPPPFRGARGGRSGGGPPNGRGGPGGGGMVGGGGHRPHEGPGGSMGSGHRSHEGPGGSMGSGHRSHEGPGHGGPHGHRPHDVPSHRGHDHRGPPPHEHRGHDGHGGGGHRGHDGGHSHGGDMSNRPVCRHFMMKGNCRYENNCAFYHPGVNGPPLP
uniprot
proteins
function
FUNCTION: Substrate-recognition component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation (By similarity). Promoter-proximal pausing by RNA polymerase II is a transcription halt following transcription initiation but prior to elongation, which acts as a checkpoint to control that transcripts are favorably configured for transcriptional elongation (By similarity). The PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H (By similarity). The PNUTS-PP1 complex also regulates RNA polymerase II transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription (By similarity). PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation (By similarity). The PNUTS-PP1 complex also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity). PNUTS-PP1 complex mediates dephosphorylation of MYC, promoting MYC stability by preventing MYC ubiquitination by the SCF(FBXW7) complex (By similarity). In addition to acts as a substrate-recognition component, PPP1R10/PNUTS also acts as a nuclear targeting subunit for the PNUTS-PP1 complex (By similarity). In some context, PPP1R10/PNUTS also acts as an inhibitor of protein phosphatase 1 (PP1) activity by preventing access to substrates (PubMed:12574161, PubMed:24591642, PubMed:9461602). {ECO:0000250|UniProtKB:Q80W00, ECO:0000250|UniProtKB:Q96QC0, ECO:0000269|PubMed:12574161, ECO:0000269|PubMed:24591642, ECO:0000269|PubMed:9461602}.
uniprot
proteins
mass_dalton
92828
uniprot
proteins
mutagenesis
MUTAGEN 396; /note="R->A: Does not abolish interaction with PPP1CA and does not reduce PPP1CA inhibition."; /evidence="ECO:0000269|PubMed:12574161"; MUTAGEN 397; /note="K->A: Does not abolish interaction with PPP1CA and reduces a little PPP1CA inhibition."; /evidence="ECO:0000269|PubMed:12574161"; MUTAGEN 399; /note="V->A: Reduces interaction with PPP1CA and reduces strongly PPP1CA inhibition."; /evidence="ECO:0000269|PubMed:12574161"; MUTAGEN 401; /note="W->A: Abolishes interaction with PPP1CA and PPP1CA inhibition."; /evidence="ECO:0000269|PubMed:12574161"; MUTAGEN 445..450; /note="Missing: Abolishes PPP1CA inhibition."; /evidence="ECO:0000269|PubMed:12574161
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Thr-398 by PKA within the region necessary for interaction with PPP1CA. {ECO:0000269|PubMed:12574161}.
uniprot
proteins
pubmed
12574161
uniprot
proteins
pubmed
15060004
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
24591642
uniprot
proteins
pubmed
35244724
uniprot
proteins
pubmed
9461602
uniprot
proteins
sequence_length
872
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96QC0, ECO:0000255|PROSITE-ProRule:PRU00649}. Chromosome {ECO:0000250|UniProtKB:Q96QC0}. Note=Found in discrete nucleoplasmic bodies and within nucleoli. Associates with RNA polymerase II (Pol II) on chromatin during pause-release checkpoint (By similarity). Associates with chromatin during interphase, excluded from condensed chromosomes during early mitosis and is reloaded onto chromosomes at the late telophase (By similarity). {ECO:0000250|UniProtKB:Q80W00, ECO:0000250|UniProtKB:Q96QC0}.
uniprot
proteins