CCDC61
entrez
729440
canonical
uniprot
Q9Y6R9
canonical
ensembl
ENSG00000104983
resolver
ensp
ENSP00000471454
resolver
genesymbol
CCDC61
resolver
hgnc
HGNC:33629
resolver
uniprot
C8CAP4
resolver
uniprot
Q9HDB6
resolver
uniprot_entry
CCD61_HUMAN
resolver
uniprot_sec
C8CAP4
resolver
uniprot_sec
Q9HDB6
resolver
amino_acid_sequence
MDQPAGLQVDYVFRGVEHAVRVMVSGQVLELEVEDRMTADQWRGEFDAGFIEDLTHKTGNFKQFNIFCHMLESALTQSSESVTLDLLTYTDLESLRNRKMGGRPGSLAPRSAQLNSKRYLILIYSVEFDRIHYPLPLPYQGKPDPVVLQGIIRSLKEELGRLQGLDGQNTRDTRENEIWHLREQVSRLASEKRELEAQLGRSREEALAGRAARQEAEALRGLVRGLELELRQERGLGHRVAGRRGQDCRRLAKELEEAKASERSLRARLKTLTSELALYKRGRRTPPVQPPPTREDRASSSRERSASRGRGAARSSSRESGRGSRGRGRPARPSPSPTGGRALRFDPTAFVKAKERKQREIQMKQQQRNRLGSGGSGDGPSVSWSRQTQPPAALTGRGDAPNRSRNRSSSVDSFRSRCSSASSCSDLEDFSESLSRGGHRRRGKPPSPTPWSGSNMKSPPVERSHHQKSLANSGGWVPIKEYSSEHQAADMAEIDARLKALQEYMNRLDMRS
uniprot
proteins
function
FUNCTION: Microtubule-binding centrosomal protein required for centriole cohesion, independently of the centrosome-associated protein/CEP250 and rootletin/CROCC linker (PubMed:31789463). In interphase, required for anchoring microtubule at the mother centriole subdistal appendages and for centrosome positioning (PubMed:31789463). During mitosis, may be involved in spindle assembly and chromatin alignment by regulating the organization of spindle microtubules into a symmetrical structure (PubMed:30354798). Has been proposed to play a role in CEP170 recruitment to centrosomes (PubMed:30354798). However, this function could not be confirmed (PubMed:31789463). Plays a non-essential role in ciliogenesis (PubMed:31789463, PubMed:32375023). {ECO:0000269|PubMed:30354798, ECO:0000269|PubMed:31789463, ECO:0000269|PubMed:32375023}.
uniprot
proteins
mass_dalton
57368
uniprot
proteins
mutagenesis
MUTAGEN 128..129; /note="FD->EA: Loss of dimerization."; /evidence="ECO:0000269|PubMed:32375023"; MUTAGEN 259; /note="K->E: Loss of microtubule-binding; when associated with E-263, E-266, E-268 and E-270."; /evidence="ECO:0000269|PubMed:32375023"; MUTAGEN 263; /note="R->E: Loss of microtubule-binding; when associated with E-259, E-266, E-268 and E-270."; /evidence="ECO:0000269|PubMed:32375023"; MUTAGEN 266; /note="R->E: Loss of microtubule-binding; when associated with E-259, E-263, E-268 and E-270."; /evidence="ECO:0000269|PubMed:32375023"; MUTAGEN 268; /note="R->E: Loss of microtubule-binding; when associated with E-259, E-263, E-266 and E-270."; /evidence="ECO:0000269|PubMed:32375023"; MUTAGEN 270; /note="K->E: Loss of microtubule-binding; when associated with E-259, E-263, E-266 and E-268."; /evidence="ECO:0000269|PubMed:32375023
uniprot
proteins
protein_family
CCDC61 family
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
30354798
uniprot
proteins
pubmed
31789463
uniprot
proteins
pubmed
32375023
uniprot
proteins
sequence_length
512
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:30354798, ECO:0000269|PubMed:31789463}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:30354798, ECO:0000269|PubMed:31789463}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:32375023}. Note=Localization at the centriolar satellite is dependent on intact microtubule network (PubMed:30354798). Localizes at the centriole subdistal appendages and proximal ends (PubMed:31789463). Localized to centrosomal/satellite-like structures with the onset of centrosome separation in early G2 (PubMed:30354798). {ECO:0000269|PubMed:30354798, ECO:0000269|PubMed:31789463}.
uniprot
proteins