CENPK
entrez
64105
canonical
uniprot
Q9BS16
canonical
ensembl
ENSG00000123219
resolver
ensp
ENSP00000242872
resolver
ensp
ENSP00000379911
resolver
ensp
ENSP00000421034
resolver
ensp
ENSP00000422421
resolver
ensp
ENSP00000425686
resolver
ensp
ENSP00000563635
resolver
ensp
ENSP00000563637
resolver
ensp
ENSP00000563638
resolver
ensp
ENSP00000599869
resolver
ensp
ENSP00000599872
resolver
ensp
ENSP00000599874
resolver
ensp
ENSP00000599875
resolver
ensp
ENSP00000743980
resolver
enst
ENST00000242872
resolver
enst
ENST00000396679
resolver
enst
ENST00000508421
resolver
enst
ENST00000510693
resolver
enst
ENST00000514814
resolver
enst
ENST00000893576
resolver
enst
ENST00000893578
resolver
enst
ENST00000893579
resolver
enst
ENST00000929810
resolver
enst
ENST00000929813
resolver
enst
ENST00000929815
resolver
enst
ENST00000929816
resolver
genesymbol
CENPK
resolver
genesymbol_syn
ICEN37
resolver
hgnc
HGNC:29479
resolver
uniprot
D6RHD3
resolver
uniprot
D6RJF0
resolver
uniprot
Q9H4L0
resolver
uniprot_entry
CENPK_HUMAN
resolver
uniprot_entry
D6RHD3_HUMAN
resolver
uniprot_entry
D6RJF0_HUMAN
resolver
uniprot_sec
Q9H4L0
resolver
amino_acid_sequence
MNQEDLDPDSTTDVGDVTNTEEELIRECEEMWKDMEECQNKLSLIGTETLTDSNAQLSLLIMQVKCLTAELSQWQKKTPETIPLTEDVLITLGKEEFQKLRQDLEMVLSTKESKNEKLKEDLEREQRWLDEQQQIMESLNVLHSELKNKVETFSESRIFNELKTKMLNIKEYKEKLLSTLGEFLEDHFPLPDRSVKKKKKNIQESSVNLITLHEMLEILINRLFDVPHDPYVKISDSFWPPYVELLLRNGIALRHPEDPTRIRLEAFHQ
uniprot
proteins
disease_involvement
DISEASE: Note=Chromosomal aberrations involving CENPK are a cause of acute leukemias. Translocation t(5;11)(q12;q23) with KMT2A/MLL1. {ECO:0000269|PubMed:8950979}.
uniprot
proteins
function
FUNCTION: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with KNL1 to recruit the NDC80 complex to the outer kinetochore. {ECO:0000269|PubMed:16622420, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:18045986}.
uniprot
proteins
mass_dalton
31655
uniprot
proteins
protein_family
CENP-K/MCM22 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16622419
uniprot
proteins
pubmed
16622420
uniprot
proteins
pubmed
16716197
uniprot
proteins
pubmed
18045986
uniprot
proteins
pubmed
19381461
uniprot
proteins
pubmed
8950979
uniprot
proteins
sequence_length
269
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
uniprot
proteins