RTRAF
entrez
51637
canonical
uniprot
Q9Y224
canonical
ensembl
ENSG00000087302
resolver
ensp
ENSP00000261700
resolver
enst
ENST00000261700
resolver
genesymbol
C14orf166
resolver
genesymbol
RTRAF
resolver
genesymbol_syn
C14orf166
resolver
hgnc
HGNC:23169
resolver
uniprot
Q549M8
resolver
uniprot_entry
Q549M8_HUMAN
resolver
uniprot_entry
RTRAF_HUMAN
resolver
amino_acid_sequence
MFRRKLTALDYHNPAGFNCKDETEFRNFIVWLEDQKIRHYKIEDRGNLRNIHSSDWPKFFEKYLRDVNCPFKIQDRQEAIDWLLGLAVRLEYGDNAEKYKDLVPDNSKTADNATKNAEPLINLDVNNPDFKAGVMALANLLQIQRHDDYLVMLKAIRILVQERLTQDAVAKANQTKEGLPVALDKHILGFDTGDAVLNEAAQILRLLHIEELRELQTKINEAIVAVQAIIADPKTDHRLGKVGR
uniprot
proteins
function
FUNCTION: Accessory subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester (PubMed:21311021, PubMed:24870230). RNA-binding protein involved in modulation of mRNA transcription by Polymerase II (PubMed:16950395). Could also play a role in RNA transport (PubMed:24608264). {ECO:0000269|PubMed:16950395, ECO:0000269|PubMed:24608264, ECO:0000269|PubMed:24870230}.; FUNCTION: (Microbial infection) In case of infection by influenza virus A (IVA), is involved in viral replication (PubMed:21900157). {ECO:0000269|PubMed:21900157}.
uniprot
proteins
mass_dalton
28068
uniprot
proteins
protein_family
RTRAF family
uniprot
proteins
pubmed
10810093
uniprot
proteins
pubmed
11507205
uniprot
proteins
pubmed
15147888
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16950395
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21311021
uniprot
proteins
pubmed
21823664
uniprot
proteins
pubmed
21900157
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24608264
uniprot
proteins
pubmed
24870230
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26864902
uniprot
proteins
pubmed
28040436
uniprot
proteins
sequence_length
244
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15147888, ECO:0000269|PubMed:24608264}. Cytoplasm, cytosol {ECO:0000269|PubMed:15147888, ECO:0000269|PubMed:24608264}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15147888}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15147888}. Note=May localize at the centrosome during mitosis (PubMed:15147888). Shuttles between the cytosol and the nucleus: enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low (PubMed:24608264). {ECO:0000269|PubMed:15147888, ECO:0000269|PubMed:24608264}.; SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26864902}. Cytoplasm {ECO:0000269|PubMed:26864902}. Note=(Microbial infection) Following influenza A virus (IAV) infection, included in influenza A virions via its association with packaged viral ribonucleoproteins (vRNP) in the nucleus and cytoplasm (PubMed:21900157, PubMed:26864902). {ECO:0000269|PubMed:21900157, ECO:0000269|PubMed:26864902}.
uniprot
proteins