CYP1A2
entrez
1544
canonical
uniprot
P05177
canonical
ensembl
ENSG00000140505
resolver
ensp
ENSP00000342007
resolver
ensp
ENSP00000542535
resolver
ensp
ENSP00000542537
resolver
ensp
ENSP00000542538
resolver
enst
ENST00000343932
resolver
enst
ENST00000872476
resolver
enst
ENST00000872478
resolver
enst
ENST00000872479
resolver
genesymbol
CYP1A2
resolver
hgnc
HGNC:2596
resolver
uniprot
Q16754
resolver
uniprot
Q6NWU3
resolver
uniprot
Q6NWU5
resolver
uniprot
Q9BXX7
resolver
uniprot
Q9UK49
resolver
uniprot_entry
CP1A2_HUMAN
resolver
uniprot_sec
Q16754
resolver
uniprot_sec
Q6NWU3
resolver
uniprot_sec
Q6NWU5
resolver
uniprot_sec
Q9BXX7
resolver
uniprot_sec
Q9UK49
resolver
amino_acid_sequence
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN
uniprot
proteins
ec_number
1.14.14.1
uniprot
proteins
ec_number
4.2.1.152
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576, PubMed:9435160). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:10681376, PubMed:11555828, PubMed:12865317, PubMed:19965576, PubMed:9435160). Catalyzes the hydroxylation of carbon-hydrogen bonds (PubMed:11555828, PubMed:12865317). Exhibits high catalytic activity for the formation of hydroxyestrogens from estrone (E1) and 17beta-estradiol (E2), namely 2-hydroxy E1 and E2 (PubMed:11555828, PubMed:12865317). Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). May act as a major enzyme for all-trans retinoic acid biosynthesis in the liver. Catalyzes two successive oxidative transformation of all-trans retinol to all-trans retinal and then to the active form all-trans retinoic acid (PubMed:10681376). Primarily catalyzes stereoselective epoxidation of the last double bond of polyunsaturated fatty acids (PUFA), displaying a strong preference for the (R,S) stereoisomer (PubMed:19965576). Catalyzes bisallylic hydroxylation and omega-1 hydroxylation of PUFA (PubMed:9435160). May also participate in eicosanoids metabolism by converting hydroperoxide species into oxo metabolites (lipoxygenase-like reaction, NADPH-independent) (PubMed:21068195). Plays a role in the oxidative metabolism of xenobiotics. Catalyzes the N-hydroxylation of heterocyclic amines and the O-deethylation of phenacetin (PubMed:14725854). Metabolizes caffeine via N3-demethylation (Probable). {ECO:0000269|PubMed:10681376, ECO:0000269|PubMed:11555828, ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:14725854, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:21068195, ECO:0000269|PubMed:21576599, ECO:0000269|PubMed:9435160, ECO:0000305|PubMed:16522833}.
uniprot
proteins
mass_dalton
58407
uniprot
proteins
pathway_participation
PATHWAY: Cofactor metabolism; retinol metabolism. {ECO:0000269|PubMed:10681376}.; PATHWAY: Steroid metabolism; cholesterol metabolism. {ECO:0000269|PubMed:21576599}.; PATHWAY: Lipid metabolism; arachidonate metabolism. {ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:21068195, ECO:0000269|PubMed:9435160}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
10681376
uniprot
proteins
pubmed
11207026
uniprot
proteins
pubmed
11295848
uniprot
proteins
pubmed
11555828
uniprot
proteins
pubmed
12865317
uniprot
proteins
pubmed
14563787
uniprot
proteins
pubmed
14725854
uniprot
proteins
pubmed
15469410
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15643613
uniprot
proteins
pubmed
15770072
uniprot
proteins
pubmed
16522833
uniprot
proteins
pubmed
17311915
uniprot
proteins
pubmed
19965576
uniprot
proteins
pubmed
21068195
uniprot
proteins
pubmed
21576599
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2575218
uniprot
proteins
pubmed
26988023
uniprot
proteins
pubmed
3000715
uniprot
proteins
pubmed
3462722
uniprot
proteins
pubmed
3517618
uniprot
proteins
pubmed
3681487
uniprot
proteins
pubmed
3755823
uniprot
proteins
pubmed
9435160
uniprot
proteins
pubmed
9884316
uniprot
proteins
sequence_length
516
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane {ECO:0000269|PubMed:21576599}; Peripheral membrane protein.
uniprot
proteins