Ddx25
entrez
58856
canonical
uniprot
Q9QY16
canonical
ensembl
ENSRNOG00000012260
resolver
ensp
ENSRNOP00000017307
resolver
genesymbol
Ddx25
resolver
genesymbol_syn
Grth
resolver
uniprot_entry
DDX25_RAT
resolver
amino_acid_sequence
MASLLWGGDAGAAESERLNSHFSNLVHPRKNLRGIRSTTVPNIDGSLNTEEDDDEDDVVDLAANSLLNKLIRQSLVESSHRVEVLQKDPSSPLYSVKTFEELRLKEELLKGIYAMGFNRPSKIQEMALPMMLAHPPQNLIAQSQSGTGKTAAFVLAMLNRVNALELFPQCLCLAPTYELALQTGRVVERMGKFCVDVEVMYAIRGNRIPRGTDVTKQIVIGTPGTVLDWCFKRKLIDLTKIRVFVLDEADVMIDTQGFSDQSIRIQRALPSECQMLLFSATFEDSVWQFAERIIPDPNVIKLRKEELTLNNIRQYYVLCENRKDKYQALCNIYGGITIGQAIIFCQTRRNAKWLTVEMMQDGHQVSLLSGELTVEQRASIIQRFRDGKEKVLITTNVCARGIDVKQVTIVVNFDLPVNQSEEPDYETYLHRIGRTGRFGKKGLAFNMIEVDKLPLLMKIQDHFNSSIKQLDPEDMDEIEKIEY
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
54791
uniprot
proteins
mutagenesis
MUTAGEN 66; /note="L->A: Enhances nuclear expression; when associated with A-67 and A-70."; /evidence="ECO:0000269|PubMed:16968703"; MUTAGEN 67; /note="L->A: Enhances nuclear expression; when associated with A-66 and A-70."; /evidence="ECO:0000269|PubMed:16968703"; MUTAGEN 70; /note="L->A: Enhances nuclear expression; when associated with A-66 and A-67."; /evidence="ECO:0000269|PubMed:16968703"; MUTAGEN 103; /note="R->A: Abolishes nuclear expression."; /evidence="ECO:0000269|PubMed:16968703"; MUTAGEN 104; /note="L->A: Decreases nuclear expression; when associated with A-108 and A-109."; /evidence="ECO:0000269|PubMed:16968703"; MUTAGEN 105; /note="K->A: Abolishes nuclear expression."; /evidence="ECO:0000269|PubMed:16968703"; MUTAGEN 108; /note="L->A: Decreases nuclear expression; when associated with A-104 and A-109."; /evidence="ECO:0000269|PubMed:16968703"; MUTAGEN 109; /note="L->A: Decreases nuclear expression; when associated with A-104 and A-108."; /evidence="ECO:0000269|PubMed:16968703
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on threonine residues. The phosphorylated form is found in the cytoplasm but not in the nucleus. {ECO:0000269|PubMed:16968703}.
uniprot
proteins
protein_family
DEAD box helicase family
uniprot
proteins
pubmed
10608860
uniprot
proteins
pubmed
12734186
uniprot
proteins
pubmed
16968703
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
483
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16968703}. Nucleus {ECO:0000269|PubMed:16968703}. Note=Detected in both cytoplasm and nucleus of testicular cells. Also detected in chromatoid bodies of round spermatids (By similarity). {ECO:0000250|UniProtKB:Q9QY15}.
uniprot
proteins