HJURP
entrez
55355
canonical
uniprot
Q8NCD3
canonical
ensembl
ENSG00000123485
resolver
ensp
ENSP00000401944
resolver
ensp
ENSP00000407208
resolver
ensp
ENSP00000414109
resolver
genesymbol
HJURP
resolver
genesymbol_syn
FAKTS
resolver
genesymbol_syn
FLEG1
resolver
genesymbol_syn
URLC9
resolver
hgnc
HGNC:25444
resolver
uniprot
A8IRH5
resolver
uniprot
B4DWR0
resolver
uniprot
B4DZV4
resolver
uniprot
Q9BUT2
resolver
uniprot
Q9NSL8
resolver
uniprot_entry
HJURP_HUMAN
resolver
uniprot_sec
A8IRH5
resolver
uniprot_sec
B4DWR0
resolver
uniprot_sec
B4DZV4
resolver
uniprot_sec
Q9BUT2
resolver
uniprot_sec
Q9NSL8
resolver
amino_acid_sequence
MLGTLRAMEGEDVEDDQLLQKLRASRRRFQRRMQRLIEKYNQPFEDTPVVQMATLTYETPQGLRIWGGRLIKERNEGEIQDSSMKPADRTDGSVQAAAWGPELPSHRTVLGADSKSGEVDATSDQEESVAWALAPAVPQSPLKNELRRKYLTQVDILLQGAEYFECAGNRAGRDVRVTPLPSLASPAVPAPGYCSRISRKSPGDPAKPASSPREWDPLHPSSTDMALVPRNDSLSLQETSSSSFLSSQPFEDDDICNVTISDLYAGMLHSMSRLLSTKPSSIISTKTFIMQNWNSRRRHRYKSRMNKTYCKGARRSQRSSKENFIPCSEPVKGTGALRDCKNVLDVSCRKTGLKLEKAFLEVNRPQIHKLDPSWKERKVTPSKYSSLIYFDSSATYNLDEENRFRTLKWLISPVKIVSRPTIRQGHGENRQREIEIRFDQLHREYCLSPRNQPRRMCLPDSWAMNMYRGGPASPGGLQGLETRRLSLPSSKAKAKSLSEAFENLGKRSLEAGRCLPKSDSSSSLPKTNPTHSATRPQQTSDLHVQGNSSGIFRKSVSPSKTLSVPDKEVPGHGRNRYDEIKEEFDKLHQKYCLKSPGQMTVPLCIGVSTDKASMEVRYQTEGFLGKLNPDPHFQGFQKLPSSPLGCRKSLLGSTAIEAPSSTCVARAITRDGTRDHQFPAKRPRLSEPQGSGRQGNSLGASDGVDNTVRPGDQGSSSQPNSEERGENTSYRMEEKSDFMLEKLETKSV
uniprot
proteins
function
FUNCTION: Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents premature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions. {ECO:0000269|PubMed:19410544, ECO:0000269|PubMed:19410545}.
uniprot
proteins
mass_dalton
83539
uniprot
proteins
mutagenesis
MUTAGEN 486; /note="S->A: Loss of phosphorylation by AKT1 and binding to YWHAG."; /evidence="ECO:0000269|PubMed:17256767
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16622419
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17256767
uniprot
proteins
pubmed
17823411
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19410544
uniprot
proteins
pubmed
19410545
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21478274
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
27499292
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
748
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus. Chromosome, centromere. Note=Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often related to storage.
uniprot
proteins