TACC3
entrez
10460
canonical
uniprot
Q9Y6A5
canonical
ensembl
ENSG00000013810
resolver
ensp
ENSP00000326550
resolver
ensp
ENSP00000478580
resolver
ensp
ENSP00000498219
resolver
ensp
ENSP00000498361
resolver
ensp
ENSP00000544257
resolver
ensp
ENSP00000544258
resolver
ensp
ENSP00000544259
resolver
ensp
ENSP00000588568
resolver
ensp
ENSP00000588570
resolver
ensp
ENSP00000588571
resolver
ensp
ENSP00000588572
resolver
ensp
ENSP00000588573
resolver
ensp
ENSP00000588574
resolver
ensp
ENSP00000624332
resolver
ensp
ENSP00000624334
resolver
enst
ENST00000313288
resolver
enst
ENST00000612220
resolver
enst
ENST00000651472
resolver
enst
ENST00000954273
resolver
enst
ENST00000954275
resolver
genesymbol
TACC3
resolver
genesymbol_syn
ERIC1
resolver
hgnc
HGNC:11524
resolver
uniprot
A0A087WUE2
resolver
uniprot
Q2NKK4
resolver
uniprot
Q3KQS5
resolver
uniprot
Q9UMQ1
resolver
uniprot_entry
A0A087WUE2_HUMAN
resolver
uniprot_entry
TACC3_HUMAN
resolver
uniprot_sec
Q2NKK4
resolver
uniprot_sec
Q3KQS5
resolver
uniprot_sec
Q9UMQ1
resolver
amino_acid_sequence
MSLQVLNDKNVSNEKNTENCDFLFSPPEVTGRSSVLRVSQKENVPPKNLAKAMKVTFQTPLRDPQTHRILSPSMASKLEAPFTQDDTLGLENSHPVWTQKENQQLIKEVDAKTTHGILQKPVEADTDLLGDASPAFGSGSSSESGPGALADLDCSSSSQSPGSSENQMVSPGKVSGSPEQAVEENLSSYSLDRRVTPASETLEDPCRTESQHKAETPHGAEEECKAETPHGAEEECRHGGVCAPAAVATSPPGAIPKEACGGAPLQGLPGEALGCPAGVGTPVPADGTQTLTCAHTSAPESTAPTNHLVAGRAMTLSPQEEVAAGQMASSSRSGPVKLEFDVSDGATSKRAPPPRRLGERSGLKPPLRKAAVRQQKAPQEVEEDDGRSGAGEDPPMPASRGSYHLDWDKMDDPNFIPFGGDTKSGCSEAQPPESPETRLGQPAAEQLHAGPATEEPGPCLSQQLHSASAEDTPVVQLAAETPTAESKERALNSASTSLPTSCPGSEPVPTHQQGQPALELKEESFRDPAEVLGTGAEVDYLEQFGTSSFKESALRKQSLYLKFDPLLRDSPGRPVPVATETSSMHGANETPSGRPREAKLVEFDFLGALDIPVPGPPPGVPAPGGPPLSTGPIVDLLQYSQKDLDAVVKATQEENRELRSRCEELHGKNLELGKIMDRFEEVVYQAMEEVQKQKELSKAEIQKVLKEKDQLTTDLNSMEKSFSDLFKRFEKQKEVIEGYRKNEESLKKCVEDYLARITQEGQRYQALKAHAEEKLQLANEEIAQVRSKAQAEALALQASLRKEQMRIQSLEKTVEQKTKENEELTRICDDLISKMEKI
uniprot
proteins
function
FUNCTION: Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer (PubMed:14767476). {ECO:0000250|UniProtKB:Q9JJ11, ECO:0000269|PubMed:14767476, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23532825}.
uniprot
proteins
mass_dalton
90360
uniprot
proteins
mutagenesis
MUTAGEN 558; /note="S->A: Disrupts localization to mitotic spindle and impairs recruitment of clathrin to mitotic spindle."; /evidence="ECO:0000269|PubMed:21297582"; MUTAGEN 566..567; /note="LL->AA: Impairs localization to mitotic spindle."; /evidence="ECO:0000269|PubMed:23918938
uniprot
proteins
protein_family
TACC family
uniprot
proteins
pubmed
10366448
uniprot
proteins
pubmed
11298601
uniprot
proteins
pubmed
14767476
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17545617
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21297582
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23532825
uniprot
proteins
pubmed
23918938
uniprot
proteins
pubmed
25596274
uniprot
proteins
sequence_length
838
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17545617}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:17545617, ECO:0000269|PubMed:21297582, ECO:0000269|PubMed:23918938}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q9PTG8}. Note=In complex with CKAP5 localized to microtubule plus-ends in mitosis and interphase. In complex with CKAP5 and clathrin localized to inter-microtubule bridges in mitotic spindles. {ECO:0000269|PubMed:25596274}.
uniprot
proteins