Hace1
entrez
209462
canonical
uniprot
Q3U0D9
canonical
ensembl
ENSMUSG00000038822
resolver
ensp
ENSMUSP00000039206
resolver
ensp
ENSMUSP00000288158
resolver
ensp
ENSMUSP00000288163
resolver
ensp
ENSMUSP00000288169
resolver
genesymbol
Hace1
resolver
genesymbol_syn
Kiaa1320
resolver
uniprot
F6VQI5
resolver
uniprot
F7ALT5
resolver
uniprot
Q5DTY7
resolver
uniprot
Q8BXY2
resolver
uniprot
Q8R160
resolver
uniprot
Q8R3G4
resolver
uniprot_entry
HACE1_MOUSE
resolver
uniprot_sec
F6VQI5
resolver
uniprot_sec
F7ALT5
resolver
uniprot_sec
Q5DTY7
resolver
uniprot_sec
Q8BXY2
resolver
uniprot_sec
Q8R160
resolver
uniprot_sec
Q8R3G4
resolver
activity_regulation
ACTIVITY REGULATION: Sterically autoinhibited in its dimeric state. {ECO:0000250|UniProtKB:Q8IYU2}.
uniprot
proteins
amino_acid_sequence
MERAMEQLNRLTRSLRRARTVELPEDNETAVYTLMPMVMADQHRSVSELLSNSKFDVNYAFGRVKRSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVNICNNEGLTAIHWLAVNGRTELLHDLVQHVTDVDVEDAMGQTALHVACQNGHKTTVQCLLDSGADINRPNVSGATPLYFACSHGQRDTAQILLLRGAKYLPDKNGVTPLDLCVQGGYGQTCEVLIQYHPRLFQTIVQMTQNEDLRENMLRQVLQHLSQQSESQYLKILTGLAEVATTNGHKLLSLSSNYDAQMKSLLRIVRIFCHVFRIGPSSPSNGIDMGYNGNKTPRSQVFKPLELLWHSLDEWLVLIATELMKNKEDSTDITSILLKQKGQDQEAPSLSAFEPPGPGSYESLPPGPGDSKPEVLAGEQEASADCQDVISVTANRLSAVIQAFYMCCSCQMPPGMTSPRFIEFVCKHDEVLKCFVNRNPKIIFDHFHFLLECPELMSRFMHIIKAQPFKDRCEWFYEHLHSGQPDSDMVHRPVSENDILLVHRDSIFRSSCEIVSKANCAKLKQGIAVRFHGEEGMGQGVVREWFDILSNEIVNPDYALFTQSADGTTFQPNSNSYVNPDHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIPVNYQDVASIDPEYAKNLQWILDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTRAIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSGMPEIDVNDWIKNTEYTSGYEREDPVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIMGGSGLQNFTIAAVPYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGSYGYTMA
uniprot
proteins
ec_number
2.3.2.26
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases (By similarity). Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion (By similarity). Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division (By similarity). Specifically binds GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens (By similarity). May also act as a transcription regulator via its interaction with RARB (PubMed:19350571). {ECO:0000250|UniProtKB:Q8IYU2, ECO:0000269|PubMed:19350571}.
uniprot
proteins
mass_dalton
102114
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q8IYU2}.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. {ECO:0000250|UniProtKB:Q8IYU2}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17694067
uniprot
proteins
pubmed
19350571
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
38332367
uniprot
proteins
sequence_length
909
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q8IYU2}. Cytoplasm {ECO:0000250|UniProtKB:Q8IYU2}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8IYU2}. Note=A significant portion localizes to the endoplasmic reticulum. Targeted to Golgi membrane via its interaction with Rab proteins. {ECO:0000250|UniProtKB:Q8IYU2}.
uniprot
proteins