Neil1
entrez
72774
canonical
uniprot
Q8K4Q6
canonical
ensembl
ENSMUSG00000032298
resolver
ensp
ENSMUSP00000034842
resolver
ensp
ENSMUSP00000141048
resolver
ensp
ENSMUSP00000237342
resolver
genesymbol
Neil1
resolver
genesymbol_syn
Nei1
resolver
uniprot
Q3U296
resolver
uniprot
Q80V58
resolver
uniprot
Q9CYT9
resolver
uniprot_entry
NEIL1_MOUSE
resolver
uniprot_entry
Q3U296_MOUSE
resolver
uniprot_sec
Q80V58
resolver
uniprot_sec
Q9CYT9
resolver
amino_acid_sequence
MPEGPELHLASHFVNETCKGLVFGGCVEKSSVSRNPEVPFESSAYHISALARGKELRLTLSPLPGSQPPQKPLSLVFRFGMSGSFQLVPAEALPRHAHLRFYTAPPAPRLALCFVDIRRFGHWDPGGEWQPGRGPCVLLEYERFRENVLRNLSDKAFDRPICEALLDQRFFNGIGNYLRAEILYRLKIPPFEKARTVLEALQQCRPSPELTLSQKIKAKLQNPDLLELCHLVPKEVVQLGGKGYGPERGEEDFAAFRAWLRCYGVPGMSSLRDRHGRTIWFQGDPGPLAPKGGRSQKKKSQETQLGAEDRKEDLPLSSKSVSRMRRARKHPPKRIAQQSEGAGLQQNQETPTAPEKGKRRGQRASTGHRRRPKTIPDTRPREAGESSAS
uniprot
proteins
ec_number
3.2.2.-
uniprot
proteins
ec_number
4.2.99.18
uniprot
proteins
function
FUNCTION: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. {ECO:0000269|PubMed:12200441, ECO:0000269|PubMed:23434322}.
uniprot
proteins
mass_dalton
43586
uniprot
proteins
protein_family
FPG family
uniprot
proteins
pubmed
12200441
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23434322
uniprot
proteins
sequence_length
389
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Chromosome. Note=During mitosis, associates with centrosomes and condensed chromatin. {ECO:0000250}.
uniprot
proteins