Cntf
entrez
12803
canonical
uniprot
P51642
canonical
ensembl
ENSMUSG00000079415
resolver
ensp
ENSMUSP00000108555
resolver
enst
ENSMUST00000112933
resolver
genesymbol
Cntf
resolver
uniprot
Q544D1
resolver
uniprot_entry
CNTF_MOUSE
resolver
uniprot_entry
Q544D1_MOUSE
resolver
amino_acid_sequence
MAFAEQSPLTLHRRDLCSRSIWLARKIRSDLTALMESYVKHQGLNKNISLDSVDGVPVASTDRWSEMTEAERLQENLQAYRTFQGMLTKLLEDQRVHFTPTEGDFHQAIHTLTLQVSAFAYQLEELMALLEQKVPEKEADGMPVTIGDGGLFEKKLWGLKVLQELSQWTVRSIHDLRVISSHHMGISAHESHYGAKQM
uniprot
proteins
function
FUNCTION: Functions as a cytokine through the ciliary neurotrophic factor receptor (CNTFR) complex. The CNTFR complex indeed consists of the membrane-anchored non-signaling receptor CNTFR and the two signaling receptor subunits IL6ST/gp130 and LIFR that transduce the signal into the cell. Functionally, promotes neuronal survival, supports differentiation of various neuronal and non-neuronal cells, and importantly regulates oligodendrocyte progenitor proliferation. Mechanistically, ligand binding to the CNTFR induces dimerization of the IL6ST/gp130 and LIFR, which activates JAK tyrosine kinases (JAK1 or JAK2 and to lesser extent TYK2) bound to their intracellular domains. These kinases subsequently phosphorylate IL6ST/gp130 and LIFR. The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducer and activators of transcription (STAT3 and to lesser extent STAT1). Can also signal via trans-signaling using soluble forms of CNTFR (By similarity). Seems to prevent the degeneration of motor axons after axotomy (By similarity). {ECO:0000250|UniProtKB:P20294, ECO:0000250|UniProtKB:P26441}.
uniprot
proteins
mass_dalton
22587
uniprot
proteins
protein_family
CNTF family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7835706
uniprot
proteins
sequence_length
198
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P26441}. Secreted {ECO:0000250|UniProtKB:Q02011}. Note=The precursor semms to be cytoplasmic (By similarity). The lack of a specific hydrophobic segment in the precursor sequence suggests that CNTF is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins (By similarity). {ECO:0000250|UniProtKB:P20294, ECO:0000250|UniProtKB:P26441}.
uniprot
proteins