FBXL19
entrez
54620
canonical
uniprot
Q6PCT2
canonical
ensembl
ENSG00000099364
resolver
ensp
ENSP00000339712
resolver
ensp
ENSP00000397913
resolver
ensp
ENSP00000455529
resolver
ensp
ENSP00000458033
resolver
enst
ENST00000338343
resolver
enst
ENST00000471231
resolver
enst
ENST00000562319
resolver
genesymbol
FBXL19
resolver
genesymbol_syn
FBL19
resolver
hgnc
HGNC:25300
resolver
uniprot
A8MT10
resolver
uniprot
H3BPZ0
resolver
uniprot
H3BVB1
resolver
uniprot
Q8N789
resolver
uniprot
Q9NT14
resolver
uniprot_entry
FXL19_HUMAN
resolver
uniprot_entry
H3BPZ0_HUMAN
resolver
uniprot_entry
H3BVB1_HUMAN
resolver
uniprot_sec
A8MT10
resolver
uniprot_sec
Q8N789
resolver
uniprot_sec
Q9NT14
resolver
amino_acid_sequence
MGMKVPGKGESGPSALLTPPMSSSSRGPGAGARRRRTRCRRCRACVRTECGDCHFCRDMKKFGGPGRMKQSCLLRQCTAPVLPHTAVCLLCGEAGKEDTVEGEEEKFGLSLMECTICNEIVHPGCLKMGKAEGVINAEIPNCWECPRCTQEGRTSKDSGEGPGRRRADNGEEGASLGSGWKLTEEPPLPPPPPRRKGPLPAGPPPEDVPGPPKRKEREAGNEPPTPRKKVKGGRERHLKKVGGDACLLRGSDPGGPGLLPPRVLNPSQAFSSCHPGLPPENWEKPKPPLASAEGPAVPSPSPQREKLERFKRMCQLLERVPDTSSSSSDSDSDSDSSGTSLSEDEAPGEARNGRRPARGSSGEKENRGGRRAVRPGSGGPLLSWPLGPAPPPRPPQLERHVVRPPPRSPEPDTLPLAAGSDHPLPRAAWLRVFQHLGPRELCICMRVCRTWSRWCYDKRLWPRMDLSRRKSLTPPMLSGVVRRQPRALDLSWTGVSKKQLMWLLNRLQGLQELVLSGCSWLSVSALGSAPLPALRLLDLRWIEDVKDSQLRELLLPPPDTKPGQTESRGRLQGVAELRLAGLELTDASLRLLLRHAPQLSALDLSHCAHVGDPSVHLLTAPTSPLRETLVHLNLAGCHRLTDHCLPLFRRCPRLRRLDLRSCRQLSPEACARLAAAGPPGPFRCPEEKLLLKDS
uniprot
proteins
function
FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that plays a role in different processes including cell migration, cell proliferation or cytoskeletal reorganization (PubMed:24684802, PubMed:29522376). Mediates RHOA ubiquitination and degradation in a ERK2-dependent manner (PubMed:23871831). Induces RAC1 and RAC3 degradation by the proteasome system and thereby regulates TGFB1-induced E-cadherin down-regulation and cell migration (PubMed:23512198, PubMed:24684802). Also mediates ubiquitination and degradation of IL-33-induced receptor IL1RL1 and subsequently blocks IL-33-mediated apoptosis (By similarity). Within the nucleus, binds to DNA containing unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides (PubMed:29276034). Recruits CDK-mediator to chromatin and targets CDK8 to promoters of silent developmental genes leading to induction of these genes during cell differentiation. In addition, plays a critical role in the recruitment of RNF20 to histone H2B leading to H2B mono-ubiquitination (By similarity). {ECO:0000250|UniProtKB:Q6PB97, ECO:0000269|PubMed:23512198, ECO:0000269|PubMed:23871831, ECO:0000269|PubMed:24684802, ECO:0000269|PubMed:29276034, ECO:0000269|PubMed:29522376}.
uniprot
proteins
mass_dalton
75707
uniprot
proteins
post_translational_modification
PTM: Acetylated by CREBBP; leading to ubiquitination and subsequent proteasomal degradation. {ECO:0000269|PubMed:29522376}.; PTM: Ubiquitinated; leading to proteasomal degradation. {ECO:0000269|PubMed:29522376}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23512198
uniprot
proteins
pubmed
23871831
uniprot
proteins
pubmed
24684802
uniprot
proteins
pubmed
29276034
uniprot
proteins
pubmed
29522376
uniprot
proteins
sequence_length
694
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23512198, ECO:0000269|PubMed:23871831, ECO:0000269|PubMed:29522376}. Nucleus {ECO:0000269|PubMed:29522376}.
uniprot
proteins