Crtc2
entrez
74343
canonical
uniprot
Q3U182
canonical
ensembl
ENSMUSG00000027936
resolver
ensp
ENSMUSP00000029545
resolver
ensp
ENSMUSP00000174882
resolver
ensp
ENSMUSP00000174883
resolver
enst
ENSMUST00000029545
resolver
genesymbol
Crtc2
resolver
genesymbol_syn
Torc2
resolver
uniprot
Q3TA52
resolver
uniprot
Q8BH09
resolver
uniprot
Q8R1U3
resolver
uniprot_entry
CRTC2_MOUSE
resolver
uniprot_entry
Q8R1U3_MOUSE
resolver
uniprot_sec
Q3TA52
resolver
uniprot_sec
Q8BH09
resolver
amino_acid_sequence
MATSGANGPGSATASASNPRKFSEKIALQKQRQAEETAAFEEVMMDIGSTRLQAQKLRLAYTRSSHYGGSLPNVNQIGCGLAEFQSPLHSPLDSSRSTRHHGLVERVQRDARRMVSPLRRYPRHIDSSPYSPAYLSPPPESGWRRMMPWGNLPAEKGQLFRLPSALNRTSSDSALHTSVMNPNPQDTYPGPTPPSVLPSRRGGGFLDGEMDAKVPAIEENVVDDKHLLKPWDAKKLSSSSSRPRSCEVPGINIFPSPDQPANVPVLPPAMNTGGSLPDLTNLHFPPPLPTPLDPEETVYPSLSGGNSTTNLTHTMTHLGISGGLGLGPSYDVPGLHSPLSHPSLQSSLSNPNLQASLSSPQPQLQGSHSHPSLPASSLAHHALPTTSLGHPSLSAPALSSSSSSSSTSSPVLSAPPYPASTPGASPRHRRVPLSPLSLPAGPADARRSQQQLPKQFSPTMSPTLSSITQGVPLDTSKLPTDQRLPPYPYSPPSLVIPTHPPTPKSLQQLPSQACLVQPSGGQPPGRQPHYGALYPPGSSGHGQQPYHRPINDFSLGNLEQFNMESPSTSLVLDPPAFSEGPGFLGSEGSMSGPQDPHVLNHQNLTHCSRHGSGPNIILTGDSSPGFSKEIAAALAGVPGFEVSASGLELGLGLEDELRMEPLGLEGLTMLSDPCALLPDPAVEDSFRSDRLQ
uniprot
proteins
function
FUNCTION: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites (PubMed:29211348). Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated (PubMed:29211348). Acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates gluconeogenesis as a component of the LKB1/AMPK/TORC2 signaling pathway. Regulates the expression of specific genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells (By similarity). {ECO:0000250|UniProtKB:Q53ET0, ECO:0000269|PubMed:16148943, ECO:0000269|PubMed:16308421, ECO:0000269|PubMed:29211348}.
uniprot
proteins
mass_dalton
73216
uniprot
proteins
mutagenesis
MUTAGEN 171; /note="S->A: Up-regulates CREB transcription factor activity. Reduces interaction with 14-3-3 proteins."; /evidence="ECO:0000269|PubMed:28235073"; MUTAGEN 171; /note="S->A: Up-regulates CREB-mediated gluconeogenic gene expression. No degradation of CRTC2. Loss of SIK2-mediated phosphorylation."; /evidence="ECO:0000269|PubMed:17805301"; MUTAGEN 213; /note="K->R: No effect on COP1-mediated degradation of TORC1 under forksolin stimulation."; MUTAGEN 214; /note="V->A: No interaction with COP1. Inhibition of degradation under exposure to FSK/INS."; /evidence="ECO:0000269|PubMed:17805301"; MUTAGEN 215; /note="P->A: No interaction with COP1. Inhibition of degradation under exposure to FSK/INS."; /evidence="ECO:0000269|PubMed:17805301"; MUTAGEN 275; /note="S->A: Does not affect interaction with 14-3-3 proteins."; /evidence="ECO:0000269|PubMed:28235073"; MUTAGEN 628; /note="K->R: Translocates to the nucleus and no COP1-mediated degradation."; /evidence="ECO:0000269|PubMed:17805301
uniprot
proteins
post_translational_modification
PTM: Phosphorylation/dephosphorylation states of Ser-171 are required for regulating transduction of CREB activity (PubMed:29211348). CRTCs/TORCs are inactive when phosphorylated, and active when dephosphorylated at this site (PubMed:29211348). This primary site of phosphorylation, is regulated by cAMP and calcium levels and is dependent on the phosphorylation of SIKs (SIK1 and SIK2) by LKB1 (By similarity). Following adenylyl cyclase activation, dephosphorylated at Ser-171 by PPP3CA/calcineurin A resulting in CRTC2 dissociation from 14-3-3 proteins and PPP3CA (PubMed:30611118). Phosphorylation at Ser-275 by MARK2 is induced under low glucose conditions and dephosphorylated in response to glucose influx (By similarity). Both insulin and AMPK increase this phosphorylation of CRTC2 while glucagon suppresses it (By similarity). Phosphorylation at Ser-275 promotes interaction with 14-3-3 proteins and translocation to the cytoplasm (By similarity). {ECO:0000250|UniProtKB:Q53ET0, ECO:0000269|PubMed:29211348, ECO:0000269|PubMed:30611118}.; PTM: Asymmetric dimethylation of arginine resisues by PRMT6 enhances the association of CRTC2 with CREB on the promoters of gluconeogenic genes. {ECO:0000269|PubMed:24570487}.
uniprot
proteins
protein_family
TORC family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16148943
uniprot
proteins
pubmed
16308421
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17805301
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23699513
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24570487
uniprot
proteins
pubmed
28235073
uniprot
proteins
pubmed
29211348
uniprot
proteins
pubmed
30611118
uniprot
proteins
sequence_length
692
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16148943, ECO:0000269|PubMed:16308421, ECO:0000269|PubMed:17805301, ECO:0000269|PubMed:29211348}. Nucleus {ECO:0000269|PubMed:16148943, ECO:0000269|PubMed:16308421, ECO:0000269|PubMed:17805301, ECO:0000269|PubMed:29211348}. Note=Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein (By similarity). In response to cAMP levels and glucagon, relocated to the nucleus (PubMed:16148943). {ECO:0000250|UniProtKB:Q53ET0, ECO:0000269|PubMed:16148943}.
uniprot
proteins