DPP6
entrez
1804
canonical
uniprot
P42658
canonical
ensembl
ENSG00000130226
resolver
ensp
ENSP00000328226
resolver
ensp
ENSP00000367001
resolver
ensp
ENSP00000384393
resolver
ensp
ENSP00000385578
resolver
ensp
ENSP00000397303
resolver
ensp
ENSP00000516214
resolver
ensp
ENSP00000516215
resolver
ensp
ENSP00000516234
resolver
enst
ENST00000404039
resolver
enst
ENST00000406326
resolver
enst
ENST00000427557
resolver
enst
ENST00000496611
resolver
enst
ENST00000706130
resolver
genesymbol
DPP6
resolver
hgnc
HGNC:3010
resolver
uniprot
A0A994J521
resolver
uniprot
A0A994J7K0
resolver
uniprot
A7E2E4
resolver
uniprot
B7Z299
resolver
uniprot
E9PDL2
resolver
uniprot
E9PF59
resolver
uniprot
F6RI98
resolver
uniprot
Q8IYG9
resolver
uniprot_entry
A0A994J521_HUMAN
resolver
uniprot_entry
A0A994J7K0_HUMAN
resolver
uniprot_entry
A7E2E4_HUMAN
resolver
uniprot_entry
B7Z299_HUMAN
resolver
uniprot_entry
DPP6_HUMAN
resolver
uniprot_entry
E9PDL2_HUMAN
resolver
uniprot_entry
E9PF59_HUMAN
resolver
uniprot_entry
F6RI98_HUMAN
resolver
uniprot_entry
Q8IYG9_HUMAN
resolver
amino_acid_sequence
MASLYQRFTGKINTSRSFPAPPEASHLLGGQGPEEDGGAGAKPLGPRAQAAAPRERGGGGGGAGGRPRFQYQARSDGDEEDELVGSNPPQRNWKGIAIALLVILVICSLIVTSVILLTPAEDNSLSQKKKVTVEDLFSEDFKIHDPEAKWISDTEFIYREQKGTVRLWNVETNTSTVLIEGKKIESLRAIRYEISPDREYALFSYNVEPIYQHSYTGYYVLSKIPHGDPQSLDPPEVSNAKLQYAGWGPKGQQLIFIFENNIYYCAHVGKQAIRVVSTGKEGVIYNGLSDWLYEEEILKTHIAHWWSPDGTRLAYAAINDSRVPIMELPTYTGSIYPTVKPYHYPKAGSENPSISLHVIGLNGPTHDLEMMPPDDPRMREYYITMVKWATSTKVAVTWLNRAQNVSILTLCDATTGVCTKKHEDESEAWLHRQNEEPVFSKDGRKFFFIRAIPQGGRGKFYHITVSSSQPNSSNDNIQSITSGDWDVTKILAYDEKGNKIYFLSTEDLPRRRQLYSANTVGNFNRQCLSCDLVENCTYFSASFSHSMDFFLLKCEGPGVPMVTVHNTTDKKKMFDLETNEHVKKAINDRQMPKVEYRDIEIDDYNLPMQILKPATFTDTTHYPLLLVVDGTPGSQSVAEKFEVSWETVMVSSHGAVVVKCDGRGSGFQGTKLLHEVRRRLGLLEEKDQMEAVRTMLKEQYIDRTRVAVFGKDYGGYLSTYILPAKGENQGQTFTCGSALSPITDFKLYASAFSERYLGLHGLDNRAYEMTKVAHRVSALEEQQFLIIHPTADEKIHFQHTAELITQLIRGKANYSLQIYPDESHYFTSSSLKQHLYRSIINFFVECFRIQDKLLTVTAKEDEEED
uniprot
proteins
disease_involvement
DISEASE: Familial paroxysmal ventricular fibrillation 2 (VF2) [MIM:612956]: A cardiac arrhythmia marked by fibrillary contractions of the ventricular muscle due to rapid repetitive excitation of myocardial fibers without coordinated contraction of the ventricle and by absence of atrial activity. {ECO:0000269|PubMed:19285295}. Note=The disease is caused by variants affecting the gene represented in this entry. A genetic variation 340 bases upstream from the ATG start site of the DPP6 gene is the cause of familial paroxysmal ventricular fibrillation type 2.; DISEASE: Intellectual developmental disorder, autosomal dominant 33 (MRD33) [MIM:616311]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD33 patients manifest microcephaly in addition to intellectual disability. {ECO:0000269|PubMed:23832105}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437, PubMed:19441798). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:18364354). Has no dipeptidyl aminopeptidase activity (PubMed:15476821, PubMed:8103397). {ECO:0000269|PubMed:15454437, ECO:0000269|PubMed:18364354, ECO:0000269|PubMed:8103397, ECO:0000305|PubMed:15476821}.
uniprot
proteins
mass_dalton
97588
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:15454437}.
uniprot
proteins
protein_family
Peptidase S9B family
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15454437
uniprot
proteins
pubmed
15476821
uniprot
proteins
pubmed
18084291
uniprot
proteins
pubmed
18174402
uniprot
proteins
pubmed
18364354
uniprot
proteins
pubmed
19285295
uniprot
proteins
pubmed
19441798
uniprot
proteins
pubmed
23832105
uniprot
proteins
pubmed
8103397
uniprot
proteins
sequence_length
865
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18364354, ECO:0000269|PubMed:19441798}; Single-pass type II membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 96..116; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins