Rtn4r
entrez
113912
canonical
uniprot
Q99M75
canonical
ensembl
ENSRNOG00000030920
resolver
ensembl
ENSRNOG00055003604
resolver
ensembl
ENSRNOG00060012784
resolver
ensembl
ENSRNOG00065008377
resolver
ensp
ENSRNOP00000041517
resolver
ensp
ENSRNOP00055004208
resolver
ensp
ENSRNOP00060017200
resolver
ensp
ENSRNOP00065009833
resolver
enst
ENSRNOT00000051037
resolver
enst
ENSRNOT00055005627
resolver
enst
ENSRNOT00060021733
resolver
enst
ENSRNOT00065013282
resolver
genesymbol
Rtn4r
resolver
genesymbol_syn
Nogor
resolver
uniprot_entry
RTN4R_RAT
resolver
amino_acid_sequence
MKRASSGGSRLLAWVLWLQAWRVATPCPGACVCYNEPKVTTSCPQQGLQAVPTGIPASSQRIFLHGNRISYVPAASFQSCRNLTILWLHSNALAGIDAAAFTGLTLLEQLDLSDNAQLRVVDPTTFRGLGHLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNNLQALPDNTFRDLGNLTHLFLHGNRIPSVPEHAFRGLHSLDRLLLHQNHVARVHPHAFRDLGRLMTLYLFANNLSMLPAEVLVPLRSLQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSEVPCNLPQRLAGRDLKRLAASDLEGCAVASGPFRPFQTNQLTDEELLGLPKCCQPDAADKASVLEPGRPASAGNALKGRVPPGDTPPGNGSGPRHINDSPFGTLPGSAEPPLTALRPGGSEPPGLPTTGPRRRPGCSRKNRTRSHCRLGQAGSGSSGTGDAEGSGALPALACSLAPLGLALVLWTVLGPC
uniprot
proteins
function
FUNCTION: Receptor for RTN4, OMG and MAG (PubMed:12037567, PubMed:15673660, PubMed:19420245). Functions as a receptor for the sialylated gangliosides GT1b and GM1. Besides, functions as a receptor for chondroitin sulfate proteoglycans. Can also bind heparin. Intracellular signaling cascades are triggered via the coreceptor NGFR (By similarity). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:18411262). Mediates axonal growth inhibition (PubMed:12037567). May play a role in regulating axon regeneration and neuronal plasticity in the adult central nervous system. Plays a role in postnatal brain development. Required for normal axon migration across the brain midline and normal formation of the corpus callosum (By similarity). Protects motoneurons against apoptosis; protection against apoptosis is probably mediated via interaction with MAG (PubMed:26335717). Acts in conjunction with RTN4 and LINGO1 in regulating neuronal precursor cell motility during cortical development. Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). {ECO:0000250|UniProtKB:Q99PI8, ECO:0000250|UniProtKB:Q9BZR6, ECO:0000269|PubMed:12037567, ECO:0000269|PubMed:15673660, ECO:0000269|PubMed:18411262, ECO:0000269|PubMed:22325200, ECO:0000269|PubMed:26335717}.
uniprot
proteins
mass_dalton
50851
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. O-glycosylated. Contains terminal sialic acid groups on its glycan chains. {ECO:0000269|PubMed:19420245}.
uniprot
proteins
protein_family
Nogo receptor family
uniprot
proteins
pubmed
11891768
uniprot
proteins
pubmed
12037567
uniprot
proteins
pubmed
12426574
uniprot
proteins
pubmed
15673660
uniprot
proteins
pubmed
18411262
uniprot
proteins
pubmed
19420245
uniprot
proteins
pubmed
20815818
uniprot
proteins
pubmed
22325200
uniprot
proteins
pubmed
26335717
uniprot
proteins
sequence_length
473
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15673660, ECO:0000269|PubMed:19420245, ECO:0000269|PubMed:22325200}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q99PI8}. Membrane raft {ECO:0000269|PubMed:15673660}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q99PI8}. Perikaryon {ECO:0000269|PubMed:15673660}. Cell projection, axon {ECO:0000269|PubMed:12426574}. Note=Detected along dendrites and axons, close to synapses, but clearly excluded from synapses. {ECO:0000250|UniProtKB:Q99PI8}.
uniprot
proteins