Clec4n
entrez
56620
canonical
uniprot
Q9JKF4
canonical
ensembl
ENSMUSG00000023349
resolver
ensp
ENSMUSP00000024118
resolver
ensp
ENSMUSP00000108173
resolver
ensp
ENSMUSP00000113733
resolver
enst
ENSMUST00000117130
resolver
genesymbol
Clec4n
resolver
genesymbol
Clec6a
resolver
genesymbol_syn
Clec4n
resolver
genesymbol_syn
Clecsf10
resolver
genesymbol_syn
Dectin2
resolver
uniprot
F7DEF5
resolver
uniprot
Q3U3M9
resolver
uniprot
Q3V2N1
resolver
uniprot
Q9JKF2
resolver
uniprot
Q9JKF3
resolver
uniprot_entry
CLC6A_MOUSE
resolver
uniprot_entry
F7DEF5_MOUSE
resolver
uniprot_entry
Q3U3M9_MOUSE
resolver
uniprot_entry
Q3V2N1_MOUSE
resolver
uniprot_sec
Q9JKF2
resolver
uniprot_sec
Q9JKF3
resolver
amino_acid_sequence
MVQERQSQGKGVCWTLRLWSAAVISMLLLSTCFIASCVVTYQFIMDQPSRRLYELHTYHSSLTCFSEGTMVSEKMWGCCPNHWKSFGSSCYLISTKENFWSTSEQNCVQMGAHLVVINTEAEQNFITQQLNESLSYFLGLSDPQGNGKWQWIDDTPFSQNVRFWHPHEPNLPEERCVSIVYWNPSKWGWNDVFCDSKHNSICEMKKIYL
uniprot
proteins
function
FUNCTION: Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: specifically recognizes and binds alpha-mannans on C.albicans hypheas (PubMed:17050534, PubMed:19703985, PubMed:20493731). Binding of C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes (PubMed:17050534, PubMed:19703985, PubMed:20493731, PubMed:32358020). Also recognizes, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production (PubMed:19124755). Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses (PubMed:21059925). {ECO:0000269|PubMed:17050534, ECO:0000269|PubMed:19124755, ECO:0000269|PubMed:19703985, ECO:0000269|PubMed:20493731, ECO:0000269|PubMed:21059925, ECO:0000269|PubMed:32358020}.
uniprot
proteins
mass_dalton
24324
uniprot
proteins
mutagenesis
MUTAGEN 17; /note="R->V: Does not affect association with Fc receptor gamma chain."; /evidence="ECO:0000269|PubMed:17050534
uniprot
proteins
pubmed
10766825
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17050534
uniprot
proteins
pubmed
19124755
uniprot
proteins
pubmed
19703985
uniprot
proteins
pubmed
20493731
uniprot
proteins
pubmed
21059925
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32358020
uniprot
proteins
sequence_length
209
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6EIG7}; Single-pass type II membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..43; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins