Stat5b
entrez
20851
canonical
uniprot
P42232
canonical
ensembl
ENSMUSG00000020919
resolver
ensp
ENSMUSP00000004143
resolver
ensp
ENSMUSP00000102981
resolver
enst
ENSMUST00000004143
resolver
enst
ENSMUST00000107358
resolver
genesymbol
Stat5b
resolver
uniprot
A2A5D5
resolver
uniprot
Q541Q5
resolver
uniprot
Q60804
resolver
uniprot
Q8K3Q1
resolver
uniprot
Q9JKM1
resolver
uniprot
Q9R0X8
resolver
uniprot_entry
STA5B_MOUSE
resolver
uniprot_sec
A2A5D5
resolver
uniprot_sec
Q541Q5
resolver
uniprot_sec
Q60804
resolver
uniprot_sec
Q8K3Q1
resolver
uniprot_sec
Q9JKM1
resolver
uniprot_sec
Q9R0X8
resolver
amino_acid_sequence
MAMWIQAQQLQGDALHQMQALYGQHFPIEVRHYLSQWIESQAWDSIDLDNPQENIKATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQSTYDRCPMELVRCIRHILYNEQRLVREANNGSSPAGSLADAMSQKHLQINQTFEELRLITQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLGQLNPQERMSRETALQQKQVSLETWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRSDRRGAESVTEEKFTILFDSQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNISSNHLEDYNSMSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRLGDLNYLIYVFPDRPKDEVYSKYYTPVPCEPATAKAADGYVKPQIKQVVPEFANASTDAGSGATYMDQAPSPVVCPQAHYNMYPPNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQWIPHAQS
uniprot
proteins
function
FUNCTION: Signal transducer and transcription activator that mediates cellular responses to cytokines, hormones and growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation. Involved in the oncostatin-M-mediated signaling pathway through type II OSM receptor complex (heterodimers composed of OSMR and IL6ST). {ECO:0000250|UniProtKB:P51692}.
uniprot
proteins
mass_dalton
90002
uniprot
proteins
mutagenesis
MUTAGEN 684; /note="T->A: Fails to interact with INSR."; /evidence="ECO:0000269|PubMed:9428692
uniprot
proteins
post_translational_modification
PTM: Tyrosine phosphorylated in response to signaling via activated KIT, resulting in translocation to the nucleus. Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2 (By similarity). Phosphorylation at Tyr-699 by PTK6 or HCK leads to an increase of its transcriptional activity (By similarity). {ECO:0000250|UniProtKB:P51692, ECO:0000269|PubMed:11773439, ECO:0000269|PubMed:21135090, ECO:0000269|PubMed:21262971}.
uniprot
proteins
protein_family
Transcription factor STAT family
uniprot
proteins
pubmed
10835485
uniprot
proteins
pubmed
11090077
uniprot
proteins
pubmed
11161808
uniprot
proteins
pubmed
11773439
uniprot
proteins
pubmed
14701862
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20639532
uniprot
proteins
pubmed
21135090
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21262971
uniprot
proteins
pubmed
24319783
uniprot
proteins
pubmed
7568026
uniprot
proteins
pubmed
7720707
uniprot
proteins
pubmed
9428692
uniprot
proteins
pubmed
9528750
uniprot
proteins
sequence_length
786
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20639532}. Nucleus {ECO:0000269|PubMed:20639532}. Note=Translocated into the nucleus in response to phosphorylation.
uniprot
proteins