Nasp
entrez
50927
canonical
uniprot
Q99MD9
canonical
ensembl
ENSMUSG00000028693
resolver
ensp
ENSMUSP00000030456
resolver
ensp
ENSMUSP00000030457
resolver
ensp
ENSMUSP00000079946
resolver
enst
ENSMUST00000030456
resolver
enst
ENSMUST00000030457
resolver
genesymbol
Nasp
resolver
uniprot
B1AU75
resolver
uniprot
B1AU76
resolver
uniprot
O35499
resolver
uniprot
O88993
resolver
uniprot
Q3V150
resolver
uniprot
Q99KE9
resolver
uniprot_entry
B1AU75_MOUSE
resolver
uniprot_entry
B1AU76_MOUSE
resolver
uniprot_entry
NASP_MOUSE
resolver
uniprot_sec
O35499
resolver
uniprot_sec
O88993
resolver
uniprot_sec
Q3V150
resolver
uniprot_sec
Q99KE9
resolver
amino_acid_sequence
MATESTAAAAIAAELVSADKIEDAPAPSTSADKMESLDVDSEAKKLLGLGQKHLVMGDIPAAVNAFQEAASLLGKKYGETANECGEAFFFYGKSLLELARMENGVLGNALEGVHVEEEEGEKTEDESLVENNDNVDEEAREELREQVYDAMGEKEAKKAEGKSLTKPETDKEQESEVEKGGREDMDISEPEEKLQETVEPTSKQLTESSEEAKEAAIPGLNEDEVASGKTEQESLCTEKGKSISGAYVQNKEFRETVEEGEEIISLEKKPKETSEDQPIRAAEKQGTLMKVVEIEAEIDPQVKSADVGGEEPKDQVATSESELGKAVLMELSGQDVEASPVVAAEAGAEVSEKPGQEITVIPNNGPVVGQSTVGDQTPSEPQTSAERLTETKDGSSVEEVKAELVPEQEEAMLPVEESEAAGDGVETKVAQKATEKAPEDKFKIAANEETPERDEQMKEGEETEGSEEEDRENDKAEETPNESVLEKKSLQENEEEEIGNLELAWDMLDLAKIIFKRQETKEAQLYAAQAHLKLGEVSVESENYIQAVEEFQACLSLQEQYLEAHDRLLAETHYQLGLAYGYNSQYDEAVAQFGKSIDVIEKRMAVLHEQMKEAEGSFTEYEKEIEELKELLPEIREKIEDAKESQRSGNVAELALKATLVESSTSGFTPSGAGASVSMIASRKPTDGASSSNCVTDISHLVRKKRKPEEESPRKDDAKKAKQEPEVNGGSGDAVSSGKEVSENMEAEAENQAESQTAEGTVESAATIKSTAC
uniprot
proteins
function
FUNCTION: Component of the histone chaperone network (By similarity). Binds and stabilizes histone H3-H4 not bound to chromatin to maintain a soluble reservoir and modulate degradation by chaperone-mediated autophagy (By similarity). Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and linker H1 histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA. {ECO:0000250|UniProtKB:P49321, ECO:0000269|PubMed:12509435, ECO:0000269|PubMed:15533935, ECO:0000269|PubMed:16728391}.
uniprot
proteins
mass_dalton
83954
uniprot
proteins
protein_family
NASP family
uniprot
proteins
pubmed
10893414
uniprot
proteins
pubmed
12509435
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15533935
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16728391
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
773
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10893414, ECO:0000269|PubMed:12509435, ECO:0000269|PubMed:16728391}. Nucleus {ECO:0000269|PubMed:10893414, ECO:0000269|PubMed:12509435, ECO:0000269|PubMed:16728391}.
uniprot
proteins