Rhbdf2
entrez
217344
canonical
uniprot
Q80WQ6
canonical
ensembl
ENSMUSG00000020806
resolver
ensp
ENSMUSP00000099317
resolver
ensp
ENSMUSP00000099318
resolver
ensp
ENSMUSP00000160338
resolver
enst
ENSMUST00000103028
resolver
enst
ENSMUST00000103029
resolver
genesymbol
Rhbdf2
resolver
genesymbol_syn
Irhom2
resolver
genesymbol_syn
Rhbdl6
resolver
genesymbol_syn
Rhor
resolver
uniprot
Q3TBR9
resolver
uniprot
Q8BJ70
resolver
uniprot
Q8K2I7
resolver
uniprot_entry
RHDF2_MOUSE
resolver
uniprot_sec
Q3TBR9
resolver
uniprot_sec
Q8BJ70
resolver
uniprot_sec
Q8K2I7
resolver
amino_acid_sequence
MASADKNGSNLPSVSGSRLQSRKPPNLSITIPPPESQAPGEQDSMLPERRKNPAYLKSVSLQEPRGRWQEGAEKRPGFRRQASLSQSIRKSTAQWFGVSGDWEGKRQNWHRRSLHHCSVHYGRLKASCQRELELPSQEVPSFQGTESPKPCKMPKIVDPLARGRAFRHPDEVDRPHAAHPPLTPGVLSLTSFTSVRSGYSHLPRRKRISVAHMSFQAAAALLKGRSVLDATGQRCRHVKRSFAYPSFLEEDAVDGADTFDSSFFSKEEMSSMPDDVFESPPLSASYFRGVPHSASPVSPDGVHIPLKEYSGGRALGPGTQRGKRIASKVKHFAFDRKKRHYGLGVVGNWLNRSYRRSISSTVQRQLESFDSHRPYFTYWLTFVHIIITLLVICTYGIAPVGFAQHVTTQLVLKNRGVYESVKYIQQENFWIGPSSIDLIHLGAKFSPCIRKDQQIEQLVRRERDIERTSGCCVQNDRSGCIQTLKKDCSETLATFVKWQNDTGPSDKSDLSQKQPSAVVCHQDPRTCEEPASSGAHIWPDDITKWPICTEQAQSNHTGLLHIDCKIKGRPCCIGTKGSCEITTREYCEFMHGYFHEDATLCSQVHCLDKVCGLLPFLNPEVPDQFYRIWLSLFLHAGIVHCLVSVVFQMTILRDLEKLAGWHRISIIFILSGITGNLASAIFLPYRAEVGPAGSQFGLLACLFVELFQSWQLLERPWKAFFNLSAIVLFLFICGLLPWIDNIAHIFGFLSGMLLAFAFLPYITFGTSDKYRKRALILVSLLVFAGLFASLVLWLYIYPINWPWIEYLTCFPFTSRFCEKYELDQVLH
uniprot
proteins
function
FUNCTION: Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation (PubMed:21439629). Does not exhibit any protease activity on its own (PubMed:21439629). {ECO:0000269|PubMed:21439629}.
uniprot
proteins
mass_dalton
93434
uniprot
proteins
protein_family
Peptidase S54 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21439629
uniprot
proteins
pubmed
29897336
uniprot
proteins
sequence_length
827
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21439629}; Multi-pass membrane protein {ECO:0000269|PubMed:21439629}.
uniprot
proteins
transmembrane_region
TRANSMEM 382..402; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 628..648; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 664..684; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 687..707; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 719..739; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 745..765; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 774..794; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins