CADM4
entrez
199731
canonical
uniprot
Q8NFZ8
canonical
ensembl
ENSG00000105767
resolver
ensp
ENSP00000222374
resolver
ensp
ENSP00000574214
resolver
enst
ENST00000222374
resolver
genesymbol
CADM4
resolver
genesymbol_syn
IGSF4C
resolver
genesymbol_syn
NECL4
resolver
genesymbol_syn
TSLL2
resolver
hgnc
HGNC:30825
resolver
uniprot
B2R7L5
resolver
uniprot
Q9Y4A4
resolver
uniprot_entry
CADM4_HUMAN
resolver
uniprot_sec
B2R7L5
resolver
uniprot_sec
Q9Y4A4
resolver
amino_acid_sequence
MGRARRFQWPLLLLWAAAAGPGAGQEVQTENVTVAEGGVAEITCRLHQYDGSIVVIQNPARQTLFFNGTRALKDERFQLEEFSPRRVRIRLSDARLEDEGGYFCQLYTEDTHHQIATLTVLVAPENPVVEVREQAVEGGEVELSCLVPRSRPAATLRWYRDRKELKGVSSSQENGKVWSVASTVRFRVDRKDDGGIIICEAQNQALPSGHSKQTQYVLDVQYSPTARIHASQAVVREGDTLVLTCAVTGNPRPNQIRWNRGNESLPERAEAVGETLTLPGLVSADNGTYTCEASNKHGHARALYVLVVYDPGAVVEAQTSVPYAIVGGILALLVFLIICVLVGMVWCSVRQKGSYLTHEASGLDEQGEAREAFLNGSDGHKRKEEFFI
uniprot
proteins
function
FUNCTION: Cell adhesion molecule, exhibiting calcium- and magnesium-independent cell-cell adhesion activity (PubMed:16261159). In its palmitoylated form, is required for proper oligodendrocyte maturation and myelination in CNS via its association with other cell adhesion molecules such as CADM2/3 and MAG (By similarity). May have tumor-suppressor activity (PubMed:16261159). {ECO:0000250|UniProtKB:Q8R464, ECO:0000269|PubMed:16261159}.
uniprot
proteins
mass_dalton
42785
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q8R464}.; PTM: Palmitoylation, specifically at Cys-347 catalyzed by ZDHHC3, is essential for its localization to the plasma membrane and protein stability. This localization is crucial for its function in CNS myelination, particularly through its associations with other cell adhesion molecules like CADM2/3 and MAG. {ECO:0000250|UniProtKB:Q8R464}.
uniprot
proteins
protein_family
Nectin family
uniprot
proteins
pubmed
11536053
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
16261159
uniprot
proteins
sequence_length
388
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8R464}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8R464}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 325..345; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins