Neurl3
entrez
214854
canonical
uniprot
Q8CJC5
canonical
ensembl
ENSMUSG00000047180
resolver
ensp
ENSMUSP00000055437
resolver
genesymbol
Neurl3
resolver
genesymbol_syn
Lincr
resolver
uniprot
Q8BS05
resolver
uniprot_entry
NEUL3_MOUSE
resolver
uniprot_sec
Q8BS05
resolver
amino_acid_sequence
MGSLLSPEANAEVPREALSFHGNATGAQVHLDDQRSTARRRSTFHDGIVFSQRPVWPGERVALRVLRHEEGWCGGLRVGFTRLDPAQVAASCLPPFVCPDLEEQSPTWAALLPEGFVRAGNVVCFWVNRRGWLFAKVNAGRPLLLRKDVLVQGAPLWAVMDVYGTTKAIELLDPKANAWIRSGEPVPESEVISGEECVICFHNTANTRLMPCGHSHFCGSCAWHIFKDTARCPICRWQIEEVAVVSSLKAEEGS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that plays a role in various biological processes such as lung development or innate immunity (PubMed:15936721, PubMed:35792897). Seems to utilize UBE2E1. Promotes innate antiviral response by catalyzing 'Lys-63'-linked ubiquitination of IRF7 (PubMed:35792897). Plays an essential role in TLR4-mediated activation of MAPK pathways by promoting 'Lys-48'-linked polyubiquitination of the phosphatase DUSP1/MKP1 (By similarity). {ECO:0000250|UniProtKB:Q96EH8, ECO:0000269|PubMed:15936721, ECO:0000269|PubMed:35792897}.
uniprot
proteins
mass_dalton
28040
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
12169584
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15936721
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
35792897
uniprot
proteins
sequence_length
254
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96EH8}.
uniprot
proteins