Sox17
entrez
20671
canonical
uniprot
Q61473
canonical
ensembl
ENSMUSG00000025902
resolver
ensp
ENSMUSP00000027035
resolver
ensp
ENSMUSP00000112351
resolver
ensp
ENSMUSP00000141894
resolver
ensp
ENSMUSP00000142116
resolver
ensp
ENSMUSP00000299923
resolver
ensp
ENSMUSP00000299925
resolver
enst
ENSMUST00000192650
resolver
genesymbol
Sox17
resolver
genesymbol_syn
Sox-17
resolver
uniprot
A0A0A6YXS3
resolver
uniprot
Q61472
resolver
uniprot
Q62248
resolver
uniprot_entry
A0A0A6YXS3_MOUSE
resolver
uniprot_entry
SOX17_MOUSE
resolver
uniprot_sec
Q61472
resolver
uniprot_sec
Q62248
resolver
amino_acid_sequence
MSSPDAGYASDDQSQPRSAQPAVMAGLGPCPWAESLSPLGDVKVKGEVVASSGAPAGTSGRAKAESRIRRPMNAFMVWAKDERKRLAQQNPDLHNAELSKMLGKSWKALTLAEKRPFVEEAERLRVQHMQDHPNYKYRPRRRKQVKRMKRVEGGFLHALVEPQAGALGPEGGRVAMDGLGLPFPEPGYPAGPPLMSPHMGPHYRDCQGLGAPALDGYPLPTPDTSPLDGVEQDPAFFAAPLPGDCPAAGTYTYAPVSDYAVSVEPPAGPMRVGPDPSGPAMPGILAPPSALHLYYGAMGSPAASAGRGFHAQPQQPLQPQAPPPPPQQQHPAHGPGQPSPPPEALPCRDGTESNQPTELLGEVDRTEFEQYLPFVYKPEMGLPYQGHDCGVNLSDSHGAISSVVSDASSAVYYCNYPDI
uniprot
proteins
function
FUNCTION: Acts as a transcription regulator that binds target promoter DNA and bends the DNA (PubMed:19328208, PubMed:24153254, PubMed:8636240). Binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3' (PubMed:8636240). Modulates transcriptional regulation via WNT3A. Inhibits Wnt signaling. Promotes degradation of activated CTNNB1. Plays a key role in the regulation of embryonic development (PubMed:11973269, PubMed:17655922, PubMed:24153254). Required for normal development of the definitive gut endoderm (PubMed:11973269). Required for normal looping of the embryonic heart tube. Plays an important role in embryonic and postnatal vascular development, including development of arteries (PubMed:24153254). Plays an important role in postnatal angiogenesis, where it is functionally redundant with SOX18 (PubMed:16895970). Required for the generation and maintenance of fetal hematopoietic stem cells, and for fetal hematopoiesis (PubMed:17655922). Probable transcriptional activator in the premeiotic germ cells. {ECO:0000269|PubMed:11973269, ECO:0000269|PubMed:16895970, ECO:0000269|PubMed:17655922, ECO:0000269|PubMed:19328208, ECO:0000269|PubMed:20802155, ECO:0000269|PubMed:24153254, ECO:0000269|PubMed:8636240}.; FUNCTION: [Isoform 2]: Has no DNA-binding activity, and does not function as transcriptional activator. {ECO:0000269|PubMed:8636240}.
uniprot
proteins
mass_dalton
44646
uniprot
proteins
pubmed
11973269
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16895970
uniprot
proteins
pubmed
17655922
uniprot
proteins
pubmed
19328208
uniprot
proteins
pubmed
20802155
uniprot
proteins
pubmed
24153254
uniprot
proteins
pubmed
8636240
uniprot
proteins
sequence_length
419
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267, ECO:0000269|PubMed:20802155, ECO:0000269|PubMed:24153254, ECO:0000269|PubMed:8636240}.
uniprot
proteins