Mfsd1
entrez
66868
canonical
uniprot
Q9DC37
canonical
ensembl
ENSMUSG00000027775
resolver
ensp
ENSMUSP00000029344
resolver
enst
ENSMUST00000029344
resolver
genesymbol
Mfsd1
resolver
uniprot
Q3UWU0
resolver
uniprot
Q8BVZ3
resolver
uniprot_entry
MFSD1_MOUSE
resolver
uniprot_sec
Q3UWU0
resolver
uniprot_sec
Q8BVZ3
resolver
amino_acid_sequence
MEDEDGEDRALLGGRREADSAVHGAPRALSALCDPSRLAHRLVVLSLMCFLGFGSYFCYDNPAALQTQVKRDMQVNTTKFMLLYAWYSWPNVVLCFLGGFLIDRIFGIRWGTVIFSCFVCIGQVIFALGGIFNAFWLMELGRFVFGIGGESLAVAQNTYAVSWFKGKELNLVFGLQLSMARIGSTVNMNLMGWLYGKIEALLGSAGHMTLGVTLMIGCITCIFSLICALALAYLDRRAEKILHKEQGKTGEVIKLRDIKDFSLPLILVFVICVCYYVAVFPFIGLGKVFFMEKFRFSSQSASAINSIVYIISAPMSPLFGLLVDKTGKNIIWVLYAVAATLVSHMMLAFTFWNPWIAMCLLGFSYSLLACALWPMVAFIVPEHQLGTAYGFMQSIQNLGLAVIAILAGMILDSKGYLLLEVFFIACVSLSLLAVVCLYLVNRAQGGNLNYSAKQRERMKLSHPE
uniprot
proteins
function
FUNCTION: Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol (PubMed:38507452). Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion (By similarity). Also essential for liver homeostasis (PubMed:31661432). {ECO:0000250|UniProtKB:Q9H3U5, ECO:0000269|PubMed:31661432, ECO:0000269|PubMed:38507452}.
uniprot
proteins
mass_dalton
51396
uniprot
proteins
mutagenesis
MUTAGEN 11..12; /note="LL->AA: Mislocalization to the plasma membrane. Localizes to lysosomes when expressed with wild-type Glmp."; /evidence="ECO:0000269|PubMed:31661432, ECO:0000269|PubMed:32959924"; MUTAGEN 76; /note="N->A: No change in molecular weight, indicating lack of N-glycosylation."; /evidence="ECO:0000269|PubMed:31661432"; MUTAGEN 449; /note="N->A: No change in molecular weight, indicating lack of N-glycosylation."; /evidence="ECO:0000269|PubMed:31661432
uniprot
proteins
post_translational_modification
PTM: Not N-glycosylated. {ECO:0000269|PubMed:31661432}.
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
27981419
uniprot
proteins
pubmed
31661432
uniprot
proteins
pubmed
32959924
uniprot
proteins
pubmed
38507452
uniprot
proteins
sequence_length
464
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:31661432, ECO:0000269|PubMed:32959924, ECO:0000269|PubMed:38507452}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 38..58; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 82..102; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 112..132; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 134..154; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 190..210; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 214..234; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 265..285; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 303..323; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 330..350; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 360..380; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 391..411; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 417..437; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins