Grk4
entrez
59077
canonical
uniprot
P70507
canonical
ensembl
ENSRNOG00000011847
resolver
ensembl
ENSRNOG00055016786
resolver
ensembl
ENSRNOG00060022523
resolver
ensembl
ENSRNOG00065031984
resolver
ensp
ENSRNOP00000015894
resolver
ensp
ENSRNOP00000101234
resolver
enst
ENSRNOT00000168890
resolver
genesymbol
Grk4
resolver
genesymbol_syn
Gprk2l
resolver
uniprot
A0ABK0LEH9
resolver
uniprot
P70508
resolver
uniprot_entry
A0ABK0LEH9_RAT
resolver
uniprot_entry
GRK4_RAT
resolver
uniprot_sec
P70508
resolver
activity_regulation
ACTIVITY REGULATION: Autophosphorylation at Ser-484 activates the protein kinase activity. Inhibited by heparin. {ECO:0000250|UniProtKB:P32298}.
uniprot
proteins
amino_acid_sequence
MELENFMANTLLLKARQGFTKKTGRSKKWRELLKLPPVSMCSDLRHSIEKDFSSLCDQQPIGRLLFRQFCNTKPDLKRCIEFLDAAAEYEVTIEEEQREFGLSIYSRFFKENSEVSLPQIPPDLVKECKCNLKQSSPSQNVFQDCAGVIYKYLSEKPFEEYQESTYYNRFLQWKWLERRPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKRILEKLHSRFVVSLAYTYETKDALCLVLTIMNGGDLKYHIYNLGNPGFEEQRAVFYAAELCCGLEDLQRERIVYRDLKPENILLDDHGHIRISDLGLALEIPEGEMVRGRVGTVGYMAPEIISHEKYTFSPDWWGLGCLIYEMIAGHSPFRKYKEKVNREEMERRVKTETEEYSERFSENAKSICSMLLTKDPSKRLGCQSDGASAVKQHPIFKDINFSRLEANMLDPPFCPDPEAIYCKDILDIGQFSVVKGVNLDTNDEIFYTQFATGCVTIPWQNEMIESGCFKDLNEYEDKGLSPLEKHKICSCILRPKRNFFHRLFRRAACLNIAHSEEREPTEH
uniprot
proteins
ec_number
2.7.11.16
uniprot
proteins
function
FUNCTION: Specifically phosphorylates the activated forms of G protein-coupled receptors, such as ADRB2, DRD1 and DRD3 (By similarity). Such receptor phosphorylation initiates beta-arrestin-mediated receptor internalization, and signaling events leading to their desensitization (By similarity). Mediates phosphorylation of DRD1 in the absence of dopamine activation, resulting in constitutive desensitization (By similarity). Plays an important role in the regulation of renal sodium handling and blood pressure (PubMed:16636192). {ECO:0000250|UniProtKB:P32298, ECO:0000269|PubMed:16636192}.
uniprot
proteins
mass_dalton
66788
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated at Ser-484 activates the protein kinase activity. {ECO:0000250|UniProtKB:P32298}.; PTM: Palmitoylated. {ECO:0000250|UniProtKB:P32298}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
GPRK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
16636192
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9607785
uniprot
proteins
sequence_length
575
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P32298}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:P32298}. Note=Both at the cell surface and dispersed in the cytoplasm under basal conditions. Receptor stimulation results in the internalization of GRK4 to the perinuclear area, where colocalization with DRD3 is observed strongly at 5 and 15 minutes. DRD3 and GRK4 colocalize in lipid rafts of renal proximal tubule cells. {ECO:0000250|UniProtKB:P32298}.
uniprot
proteins