P10868
uniprot
P10868
canonical
amino_acid_sequence
MSSSAASPLFAPGEDCGPAWRAAPAAYDTSDTHLQILGKPVMERWETPYMHSLAAAAASRGGRVLEVGFGMAIAASRVQQAPIKEHWIIECNDGVFQRLQNWALKQPHKVVPLKGLWEEEAPTLPDGHFDGILYDTYPLSEETWHTHQFNFIKTHAFRLLKPGGILTYCNLTSWGELMKSKYTDITAMFEETQVPALLEAGFQRENICTEVMALVPPADCRYYAFPQMITPLVTKH
uniprot
proteins
ec_number
2.1.1.2
uniprot
proteins
function
FUNCTION: Converts guanidinoacetate to creatine, using S-adenosylmethionine as the methyl donor. Important in nervous system development. {ECO:0000250|UniProtKB:Q14353}.
uniprot
proteins
mass_dalton
26407
uniprot
proteins
mutagenesis
MUTAGEN 46; /note="E->D: Reduces affinity for substrate and S-adenosyl-L-methionine about 2-fold."; /evidence="ECO:0000269|PubMed:15533043"; MUTAGEN 46; /note="E->Q: Reduces affinity for substrate and S-adenosyl-L-methionine about 4-fold."; /evidence="ECO:0000269|PubMed:15533043"; MUTAGEN 46; /note="E->S: Loss of activity."; /evidence="ECO:0000269|PubMed:15533043"; MUTAGEN 135; /note="D->A: Loss of activity."; /evidence="ECO:0000269|PubMed:15533043"; MUTAGEN 135; /note="D->E: Reduces affinity for S-adenosyl-L-methionine 500-fold. Reduces affinity for substrate about 40-fold."; /evidence="ECO:0000269|PubMed:15533043"; MUTAGEN 135; /note="D->N: Reduces affinity for S-adenosyl-L-methionine 2000-fold. Reduces affinity for substrate about 40-fold."; /evidence="ECO:0000269|PubMed:15533043"; MUTAGEN 222; /note="Y->F: Reduces affinity for S-adenosyl-L-methionine about 5-fold. Reduces affinity for substrate about 40-fold."; /evidence="ECO:0000269|PubMed:15533043
uniprot
proteins
pathway_participation
PATHWAY: Amine and polyamine biosynthesis; creatine biosynthesis; creatine from L-arginine and glycine: step 2/2.
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
RMT2 methyltransferase family
uniprot
proteins
pubmed
11165387
uniprot
proteins
pubmed
12079381
uniprot
proteins
pubmed
12925789
uniprot
proteins
pubmed
15533043
uniprot
proteins
pubmed
15918910
uniprot
proteins
pubmed
1990977
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
3277179
uniprot
proteins
pubmed
3419933
uniprot
proteins
sequence_length
236
uniprot
proteins