PPARGC1A
entrez
10891
canonical
uniprot
Q9UBK2
canonical
ensembl
ENSG00000109819
resolver
ensp
ENSP00000264867
resolver
ensp
ENSP00000424181
resolver
ensp
ENSP00000481498
resolver
ensp
ENSP00000643503
resolver
genesymbol
PPARGC1A
resolver
genesymbol_syn
LEM6
resolver
genesymbol_syn
PGC1
resolver
genesymbol_syn
PGC1A
resolver
genesymbol_syn
PPARGC1
resolver
hgnc
HGNC:9237
resolver
uniprot
B7Z406
resolver
uniprot
D6RBF3
resolver
uniprot
G8DM16
resolver
uniprot
I3RTT5
resolver
uniprot
I3RTT6
resolver
uniprot
I3RTT7
resolver
uniprot
I3RTT8
resolver
uniprot
I3RTT9
resolver
uniprot
Q3LIG1
resolver
uniprot
Q4W5M7
resolver
uniprot
Q9UN32
resolver
uniprot_entry
PRGC1_HUMAN
resolver
uniprot_sec
B7Z406
resolver
uniprot_sec
D6RBF3
resolver
uniprot_sec
G8DM16
resolver
uniprot_sec
I3RTT5
resolver
uniprot_sec
I3RTT6
resolver
uniprot_sec
I3RTT7
resolver
uniprot_sec
I3RTT8
resolver
uniprot_sec
I3RTT9
resolver
uniprot_sec
Q3LIG1
resolver
uniprot_sec
Q4W5M7
resolver
uniprot_sec
Q9UN32
resolver
amino_acid_sequence
MAWDMCNQDSESVWSDIECAALVGEDQPLCPDLPELDLSELDVNDLDTDSFLGGLKWCSDQSEIISNQYNNEPSNIFEKIDEENEANLLAVLTETLDSLPVDEDGLPSFDALTDGDVTTDNEASPSSMPDGTPPPQEAEEPSLLKKLLLAPANTQLSYNECSGLSTQNHANHNHRIRTNPAIVKTENSWSNKAKSICQQQKPQRRPCSELLKYLTTNDDPPHTKPTENRNSSRDKCTSKKKSHTQSQSQHLQAKPTTLSLPLTPESPNDPKGSPFENKTIERTLSVELSGTAGLTPPTTPPHKANQDNPFRASPKLKSSCKTVVPPPSKKPRYSESSGTQGNNSTKKGPEQSELYAQLSKSSVLTGGHEERKTKRPSLRLFGDHDYCQSINSKTEILINISQELQDSRQLENKDVSSDWQGQICSSTDSDQCYLRETLEASKQVSPCSTRKQLQDQEIRAELNKHFGHPSQAVFDDEADKTGELRDSDFSNEQFSKLPMFINSGLAMDGLFDDSEDESDKLSYPWDGTQSYSLFNVSPSCSSFNSPCRDSVSPPKSLFSQRPQRMRSRSRSFSRHRSCSRSPYSRSRSRSPGSRSSSRSCYYYESSHYRHRTHRNSPLYVRSRSRSPYSRRPRYDSYEEYQHERLKREEYRREYEKRESERAKQRERQRQKAIEERRVIYVGKIRPDTTRTELRDRFEVFGEIEECTVNLRDDGDSYGFITYRYTCDAFAALENGYTLRRSNETDFELYFCGRKQFFKSNYADLDSNSDDFDPASTKSKYDSLDFDSLLKEAQRSLRR
uniprot
proteins
function
FUNCTION: Transcriptional coactivator for steroid receptors and nuclear receptors (PubMed:10713165, PubMed:20005308, PubMed:21376232, PubMed:28363985, PubMed:32433991). Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter (PubMed:10713165, PubMed:20005308, PubMed:21376232). Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis (PubMed:10713165, PubMed:20005308, PubMed:21376232). Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism (PubMed:10713165, PubMed:20005308, PubMed:21376232). Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program (PubMed:16753578, PubMed:23142079). Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner (PubMed:23836911). Also involved in the integration of the circadian rhythms and energy metabolism (By similarity). Required for oscillatory expression of clock genes, such as BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK (By similarity). {ECO:0000250|UniProtKB:O70343, ECO:0000269|PubMed:10713165, ECO:0000269|PubMed:16753578, ECO:0000269|PubMed:20005308, ECO:0000269|PubMed:21376232, ECO:0000269|PubMed:23142079, ECO:0000269|PubMed:23836911, ECO:0000269|PubMed:28363985, ECO:0000269|PubMed:32433991}.
uniprot
proteins
mass_dalton
91027
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by AMPK in skeletal muscle increases activation of its own promoter. Phosphorylated by CLK2. {ECO:0000250|UniProtKB:O70343}.; PTM: Heavily acetylated by KAT2A/GCN5 under conditions of high nutrients, leading to inactivation of PPARGC1A (PubMed:16753578, PubMed:20005308, PubMed:23142079). Deacetylated by SIRT1 in low nutrients/high NAD conditions, leading to its activation (PubMed:20005308). {ECO:0000269|PubMed:16753578, ECO:0000269|PubMed:20005308, ECO:0000269|PubMed:23142079}.; PTM: Ubiquitinated. Ubiquitination by RNF34 induces proteasomal degradation. {ECO:0000269|PubMed:22064484}.
uniprot
proteins
pubmed
10585775
uniprot
proteins
pubmed
10643692
uniprot
proteins
pubmed
10713165
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16753578
uniprot
proteins
pubmed
17050673
uniprot
proteins
pubmed
20005308
uniprot
proteins
pubmed
21376232
uniprot
proteins
pubmed
22009745
uniprot
proteins
pubmed
22064484
uniprot
proteins
pubmed
22589246
uniprot
proteins
pubmed
23142079
uniprot
proteins
pubmed
23836911
uniprot
proteins
pubmed
28363985
uniprot
proteins
pubmed
32433991
uniprot
proteins
sequence_length
798
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:10713165}. Nucleus, PML body {ECO:0000250|UniProtKB:O70343}.; SUBCELLULAR LOCATION: [Isoform B4]: Nucleus {ECO:0000269|PubMed:22589246}.; SUBCELLULAR LOCATION: [Isoform B4-8a]: Cytoplasm {ECO:0000269|PubMed:22589246}. Nucleus {ECO:0000269|PubMed:22589246}.; SUBCELLULAR LOCATION: [Isoform B5]: Nucleus {ECO:0000269|PubMed:22589246}. Nucleus, PML body {ECO:0000269|PubMed:22589246}.; SUBCELLULAR LOCATION: [Isoform 9]: Nucleus {ECO:0000269|PubMed:22009745}.
uniprot
proteins