Phf19
entrez
74016
canonical
uniprot
Q9CXG9
canonical
ensembl
ENSMUSG00000026873
resolver
ensp
ENSMUSP00000028232
resolver
ensp
ENSMUSP00000343587
resolver
enst
ENSMUST00000028232
resolver
genesymbol
Phf19
resolver
genesymbol_syn
Pcl3
resolver
uniprot_entry
PHF19_MOUSE
resolver
amino_acid_sequence
METQALEPGTLEAFGATSPNKGGLSKTKKNFKDLMSKVTEGQFVLCRWTDGLYYLGKIKRVSSPKQSCLVTFEDNSKYWVLWKDIQHAGVPGEEPKCDVCMGKTSGPMNEILICGKCGLGYHQQCHIPIAVDANWPLLTHWFCRRCIFALAVRKGGALKKGAIAKTLQAVKMVLSYQPEELDWDSPHRTNQQQCYCYCGGPGEWYLRMLQCYRCRQWFHEACTQCLSEPMVFGDRFYLFFCSVCNQGPEYIERLPLRWVDIVHLALYNLGVQSKKRYFDFEEILAFVNHHWELLQLGKLTSTPMTERGPHLLNALNSYKSRFLCGKEIKKKKCIFRLRIRVPPAPPGKLLPDRALMPSDKGTSELLRKKGKSKPGLLPQEPQQQKRRVYRRKRSKFLLEDAIPSSDFTSAWSTDHHLASIFDFTLDEIQSLKSGSSGQTFFSDVDSTDAASTSGSASTSLSYDSRWTVGSRKRKLTAKVHRPLRAKQRAAELEGRCASDSNAEGAVGPEQPDEGIDSHTLESISGDDSSLSHLKSSITNYFGAAGRLACGEKYRVLARRVTPEGKVQYLLEWEGTTPY
uniprot
proteins
function
FUNCTION: Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:22438827, PubMed:23104054, PubMed:23160351, PubMed:23273982). Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing (PubMed:23160351). Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal (PubMed:22438827). Also binds histone H3 dimethylated at 'Lys-36' (H3K36me2) (By similarity). {ECO:0000250|UniProtKB:Q5T6S3, ECO:0000269|PubMed:22438827, ECO:0000269|PubMed:23104054, ECO:0000269|PubMed:23160351, ECO:0000269|PubMed:23273982}.
uniprot
proteins
mass_dalton
65236
uniprot
proteins
mutagenesis
MUTAGEN 48; /note="W->A: Impairs ability to promote H3K27me3 methylation without affecting ability to associate with the PRC2 complex; when associated with A-54."; /evidence="ECO:0000269|PubMed:22438827"; MUTAGEN 54; /note="Y->A: Impairs ability to promote H3K27me3 methylation without affecting ability to associate with the PRC2 complex; when associated with A-48."; /evidence="ECO:0000269|PubMed:22438827"; MUTAGEN 72; /note="F->A: Impairs ability to promote H3K27me3 methylation without affecting ability to associate with the PRC2 complex; when associated with A-74."; /evidence="ECO:0000269|PubMed:22438827"; MUTAGEN 74; /note="D->A: Impairs ability to promote H3K27me3 methylation without affecting ability to associate with the PRC2 complex; when associated with A-72."; /evidence="ECO:0000269|PubMed:22438827"; MUTAGEN 75; /note="N->S: Does not affect ability to promote H3K27me3 methylation; when associated with S-78."; /evidence="ECO:0000269|PubMed:22438827"; MUTAGEN 78; /note="Y->S: Does not affect ability to promote H3K27me3 methylation; when associated with S-75."; /evidence="ECO:0000269|PubMed:22438827
uniprot
proteins
protein_family
Polycomblike family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22438827
uniprot
proteins
pubmed
23104054
uniprot
proteins
pubmed
23160351
uniprot
proteins
pubmed
23273982
uniprot
proteins
sequence_length
578
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22438827, ECO:0000269|PubMed:23104054, ECO:0000269|PubMed:23160351}. Note=Localizes to chromatin as part of the PRC2 complex. {ECO:0000269|PubMed:22438827, ECO:0000269|PubMed:23104054, ECO:0000269|PubMed:23160351}.
uniprot
proteins