Ppp4r2
entrez
232314
canonical
uniprot
Q0VGB7
canonical
ensembl
ENSMUSG00000052144
resolver
ensp
ENSMUSP00000066314
resolver
ensp
ENSMUSP00000145102
resolver
enst
ENSMUST00000063854
resolver
genesymbol
Ppp4r2
resolver
uniprot
A0A0R4J0U2
resolver
uniprot
Q4G0D4
resolver
uniprot
Q6P6N7
resolver
uniprot
Q6PHU6
resolver
uniprot
Q8BUU5
resolver
uniprot_entry
A0A0R4J0U2_MOUSE
resolver
uniprot_entry
PP4R2_MOUSE
resolver
uniprot_sec
Q4G0D4
resolver
uniprot_sec
Q6P6N7
resolver
uniprot_sec
Q6PHU6
resolver
uniprot_sec
Q8BUU5
resolver
amino_acid_sequence
MDVERLQEALKDFEKRGKKEVCPVLDQFLCHVAKTGETMIQWSQFKGYFIFKLEKVMDDFRTSAPEPRGPPNPNVEYIPFDEMKERILKIVTGFNGIPFTIQRLCELLTDPRRNYTGTDKFLRGVEKNVMVVSCVCPSSEKNNSNSLNRMNGVMFPGNSPNYTDRSNINGPGTPRPLNRPKLSLSAPLTTNGLPESTDSKDSELQLSEEKGHSDSSASESEVSLLSPVKNKHPDEDAVESEEHEVKRLKFDKEGDVRETASQTVSGEVSSVRAEETETAAPPPDKDRESRTRQHCTEEEEEEEEEEEEEEEESFMTPREMVPERKNQEKESDDALTVNEETSEESHQMEGSGVSPAQTDSTSERSDSAGASRSGSDCLETQESGGPPSSKTGESVSVPSSMESEEATEVTDDPMEQD
uniprot
proteins
function
FUNCTION: Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers. Its interaction with the SMN complex leads to enhance the temporal localization of snRNPs, suggesting a role of PPP4C in maturation of spliceosomal snRNPs. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on 'Ser-140' (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair (By similarity). Mediates RPA2 dephosphorylation by recruiting PPP4C to RPA2 in a DNA damage-dependent manner. RPA2 dephosphorylation is required for the efficient RPA2-mediated recruitment of RAD51 to chromatin following double strand breaks, an essential step for DNA repair (By similarity). {ECO:0000250|UniProtKB:Q9NY27}.
uniprot
proteins
mass_dalton
46479
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the SCF(FBXO42) complex; leading to proteasomal degradation. {ECO:0000250|UniProtKB:P60510}.
uniprot
proteins
protein_family
PPP4R2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
417
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9NY27}. Nucleus {ECO:0000250|UniProtKB:Q9NY27}. Note=Ionizing radiation induces relocalization to nuclear foci and colocalization with RPA2. {ECO:0000250|UniProtKB:Q9NY27}.
uniprot
proteins