CCNO
entrez
10309
canonical
uniprot
P22674
canonical
ensembl
ENSG00000152669
resolver
ensp
ENSP00000282572
resolver
genesymbol
CCNO
resolver
hgnc
HGNC:18576
resolver
uniprot
A8K1W5
resolver
uniprot
Q0P6J2
resolver
uniprot
Q9H6B0
resolver
uniprot
Q9UMD5
resolver
uniprot_entry
CCNO_HUMAN
resolver
uniprot_sec
A8K1W5
resolver
uniprot_sec
Q0P6J2
resolver
uniprot_sec
Q9H6B0
resolver
uniprot_sec
Q9UMD5
resolver
amino_acid_sequence
MVTPCPTSPSSPAARAGRRDNDQNLRAPVKKSRRPRLRRKQPLHPLNPCPLPGDSGICDLFESPSSGSDGAESPSAARGGSPLPGPAQPVAQLDLQTFRDYGQSCYAFRKAQESHFHPREALARQPQVTAESRCKLLSWLIPVHRQFGLSFESLCLTVNTLDRFLTTTPVAADCFQLLGVTSLLIACKQVEVHPPRVKQLLALCCGAFSRQQLCNLECIVLHKLHFTLGAPTISFFLEHFTHARVEAGQAEASEALEAQALARGVAELSLADYAFTSYSPSLLAICCLALADRMLRVSRPVDLRLGDHPEAALEDCMGKLQLLVAINSTSLTHMLPVQICEKCSLPPSSK
uniprot
proteins
disease_involvement
DISEASE: Ciliary dyskinesia, primary, 29 (CILD29) [MIM:615872]: A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. CILD29 patients do not exhibit situs inversus, a congenital abnormality in which visceral organs are opposite to their normal positions (situs solitus) due to lateral transposition. {ECO:0000269|PubMed:24747639, ECO:0000269|PubMed:26777464}. Note=The disease is caused by variants affecting the gene represented in this entry. Marked reduction of cilia in multiciliate cells due to defective mother centriole generation and placement. Remaining cilia correctly express axonemal motor proteins, are motile and do not show beating defects. Defects are probably caused by a strong reduction in the number of multiple motile cilia covering the cell surface in respiratory epithelial cells (PubMed:24747639). {ECO:0000269|PubMed:24747639}.
uniprot
proteins
function
FUNCTION: Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking. {ECO:0000269|PubMed:24747639, ECO:0000269|PubMed:26777464}.
uniprot
proteins
mass_dalton
38096
uniprot
proteins
protein_family
Cyclin family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16697536
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
2001396
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24747639
uniprot
proteins
pubmed
26777464
uniprot
proteins
pubmed
28860486
uniprot
proteins
pubmed
30087414
uniprot
proteins
pubmed
8419333
uniprot
proteins
sequence_length
350
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24747639}. Nucleus, nucleolus {ECO:0000269|PubMed:28860486, ECO:0000269|PubMed:30087414}. Note=Localizes to the apical part of cytoplasm. {ECO:0000269|PubMed:24747639}.
uniprot
proteins