Pfkm
entrez
18642
canonical
uniprot
P47857
canonical
ensembl
ENSMUSG00000033065
resolver
ensp
ENSMUSP00000059801
resolver
ensp
ENSMUSP00000132803
resolver
ensp
ENSMUSP00000232235
resolver
ensp
ENSMUSP00000232236
resolver
ensp
ENSMUSP00000232267
resolver
genesymbol
Pfkm
resolver
genesymbol_syn
Pfk-m
resolver
genesymbol_syn
Pfka
resolver
uniprot
C8CMN5
resolver
uniprot
C8CMN6
resolver
uniprot
C8CMN7
resolver
uniprot
O35513
resolver
uniprot
Q543L1
resolver
uniprot
Q9JK94
resolver
uniprot_entry
PFKAM_MOUSE
resolver
uniprot_sec
C8CMN5
resolver
uniprot_sec
C8CMN6
resolver
uniprot_sec
C8CMN7
resolver
uniprot_sec
O35513
resolver
uniprot_sec
Q543L1
resolver
uniprot_sec
Q9JK94
resolver
activity_regulation
ACTIVITY REGULATION: Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate. {ECO:0000255|HAMAP-Rule:MF_03184}.
uniprot
proteins
amino_acid_sequence
MTHEEHHAAKTLGIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGEHIREATWESVSMMLQLGGTVIGSARCKDFREREGRLRAAHNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLNDLQKDGKITAEEATKSSYLNIVGLVGSIDNDFCGTDMTIGTDSALHRIVEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTPACVVSLSGNQAVRLPLMECVQVTKDVTKAMDEKRFDEAIKLRGRSFMNNWEVYKLLAHVRPPVSKGGLHTVAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKNLEQISANITKFNIQGLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSIGADTALNTICTTCDRIKQSAAGTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQVNVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANTPDSGCVLGMRKRALVFQPVTELKDQTDFEHRIPKEQWWLKLRPILKILAKYEIDLDTSDHAHLEHISRKRSGEAAV
uniprot
proteins
ec_number
2.7.1.11
uniprot
proteins
function
FUNCTION: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. {ECO:0000255|HAMAP-Rule:MF_03184, ECO:0000269|PubMed:19889946}.
uniprot
proteins
mass_dalton
85269
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4. {ECO:0000255|HAMAP-Rule:MF_03184}.
uniprot
proteins
post_translational_modification
PTM: GlcNAcylation decreases enzyme activity. {ECO:0000250}.
uniprot
proteins
protein_family
ATP-dependent PFK group I subfamily
uniprot
proteins
protein_family
Eukaryotic two domain clade 'E' sub-subfamily
uniprot
proteins
protein_family
Phosphofructokinase type A (PFKA) family
uniprot
proteins
pubmed
11137296
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19889946
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7980403
uniprot
proteins
sequence_length
780
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03184}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell projection, cilium, flagellum {ECO:0000269|PubMed:19889946}. Note=Principal piece region of the sperm flagellum. {ECO:0000269|PubMed:19889946}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell projection, cilium, flagellum {ECO:0000269|PubMed:19889946}. Note=Principal piece region of the sperm flagellum. {ECO:0000269|PubMed:19889946}.
uniprot
proteins