Gpatch3
entrez
242691
canonical
uniprot
Q8BIY1
canonical
ensembl
ENSMUSG00000028850
resolver
ensp
ENSMUSP00000030662
resolver
enst
ENSMUST00000030662
resolver
genesymbol
Gpatch3
resolver
genesymbol_syn
Gpatc3
resolver
uniprot
A2A9E8
resolver
uniprot_entry
GPTC3_MOUSE
resolver
uniprot_sec
A2A9E8
resolver
amino_acid_sequence
MASPRELDEESPVYLVVSGIPAVLRSAQLRSYFSQFREQRGGGFLCFHYRHRPERGPPQASPEAARAGPDPAAEDPVLAQAPASDARAVRARGSAAAQTRTCCCVVSVRGAAQAQRLLRMYSGRRWLDSQGTWLPGRCLIRRLRLPTEVSDLGSFPFKTRKELQSRRAENEAFTLADLKQLPELNPPVLMPNGNVGTPLRVFLELIRSCRLPPRIITQLQLQFPKTGSSRRYGNVPFLYEDSETVEQEEHVYTAEGEEIPQGSCSEDPAAGSFDEPEDEGQQQEEEEESGSEEDDDRGEEWERHEALHEDVTGQERTTERLFEEEIELKWEKGGSGLVFYTDAQFWQEEEGDFDEQTADDWDVDMSVYYDRDGGDKDARDSVQMRLERRLREGQEDGSVLGGQVGTFERHTKGIGRKVMERQGWAEGQGLGSRCSGVPEALDGDGQHPRCKRGLGYHGEKLQPFRQLKRPRRTGLGLISTIYDEPLPQDQGETLLRRQPPTSMKFRTDMTFVKGSSCALDRPEPE
uniprot
proteins
function
FUNCTION: Involved in transcriptional regulation. It is able to activate transcription from CXCR4 promoter and therefore it might control neural crest cell migration involved in ocular and craniofacial development. Is a negative regulator of immune antiviral response, acting via down-regulation of RIG-I-like receptors signaling and inhibition of type I interferon production. The control mechanism involves interaction with mitochondrial MAVS and inhibition of MAVS assembly with downstream proteins implicated in antiviral response, such as TBK1 and TRAF6. {ECO:0000250|UniProtKB:Q96I76}.
uniprot
proteins
mass_dalton
59180
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
525
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96I76}. Cytoplasm {ECO:0000250|UniProtKB:Q96I76}.
uniprot
proteins