Jmjd1c
entrez
108829
canonical
uniprot
Q69ZK6
canonical
ensembl
ENSMUSG00000037876
resolver
ensp
ENSMUSP00000056227
resolver
ensp
ENSMUSP00000133700
resolver
ensp
ENSMUSP00000134551
resolver
ensp
ENSMUSP00000310010
resolver
ensp
ENSMUSP00000310011
resolver
ensp
ENSMUSP00000310012
resolver
ensp
ENSMUSP00000310015
resolver
enst
ENSMUST00000051446
resolver
enst
ENSMUST00000173689
resolver
genesymbol
Jmjd1c
resolver
genesymbol_syn
Jhdm2c
resolver
genesymbol_syn
Kiaa1380
resolver
uniprot
A0A0A0MQ98
resolver
uniprot
E9QMM8
resolver
uniprot
G3UZM1
resolver
uniprot
Q6NV48
resolver
uniprot
Q8BUF5
resolver
uniprot
Q8C4I5
resolver
uniprot
Q8C5Q9
resolver
uniprot_entry
A0A0A0MQ98_MOUSE
resolver
uniprot_entry
JHD2C_MOUSE
resolver
uniprot_sec
E9QMM8
resolver
uniprot_sec
G3UZM1
resolver
uniprot_sec
Q6NV48
resolver
uniprot_sec
Q8BUF5
resolver
uniprot_sec
Q8C4I5
resolver
uniprot_sec
Q8C5Q9
resolver
activity_regulation
ACTIVITY REGULATION: Demethylase activity is regulated post-translationally via phosphorylation. {ECO:0000250|UniProtKB:Q15652}.
uniprot
proteins
amino_acid_sequence
MAVETRPELVGKRFLCVAAGEDARPERGQSGCGRGWRAGVIRAVSHRDRGHPDLAVYVEFDDLEWDKREWVRVYEDFSTFLVEYHLIWAKRKDPSQTQGSKSRQIQWPALTFKPLVENSIPSSITAVEFLIDKQLDFLTEDSAFQPYQDDIDSLKPVLRDNPQLHAEVKVWVKEQKVQEIFMQGPYSLNGYRVRVYRQDSATQWFTGIITHHDLFTRTMIVMNDQVLEPQNVDPSMVQMTFLDDVVHSLLKGENIGITSRRRSRASQNISTVHGHYTRAQANSPRPAMNSQAAVPKQNTHQQQQQRSIRPNKRKGSDSSIPDEEKMKEDKYDCVSRGENPKGKNKHVVTKRRKPEEAEKRLSMKRLRTDNASDASESSDAESSSKRVTETSSSEPMPEYEPKNKVTSKVNGEEGQSQAAEEAGEETLIDTRPPWDQMQEDKNHNEGEKPKSTDSHLQDKMTLRSSEQATVADHNSNDSVLQECNVENQRTVELLPKDRLVSRTPTPKCVTDIKNDTHSERAAQENLNTFGLQTPENMDPNVSDSKHSNAKYLETAKQDCDQSWVSDVVKVDLTQSSVTNAPSGSDKRDTEKERNHYVSYMSSLSAVSVTEDQLHKRSPPPETIKAKLTTSVDTQKAKSSSSPEVVKPKITHSPDSVKSKAAYGNSQAVGERRLANKIEHELSRGSFHPVPTRGSALETTKSPLIIDKNEHFTVYRDPALIGSETGANHISPFLSQHPFSLHSSSHRTCLNPGTHHPALTPGPHLLAGSTSQTPLPTINTHPLTSGPHHPVHHPHLLPTVLPGVPTASLLGGHPRLESAHASSLSHLALAHQQQQQLLQHQSPHLLGQAHPSASYNQLGLYPIIWQYPNGTHAYSGLGLPSSKWVHPENAVNAEASLRRNSPSPWLHQPTPVTSADGIGLLSHIPVRPSSAEPHRPHKITVHSSPPLTKTLADHHKEELERKAFMEPLRSNASTSVKGDLDLNRSQAGKDCHLHRHFVGPRPPQETGERLNKYKEEHRRILQESIDVAPFTTKIKGHEVERENYSRVVPSSSSPKSHAIKQDKDVDRSVSEIYKMKHSVPQSLPQSNYFTTLSNSVVNEPPRSYPSKEVSNIYTEKQNNNLSATANPQTHSFISSLSKPPPLIKHQPESESLVGKIPDHLPHQSASHSVTTFRSDCRSPTHLTVSSTNALRSMPALHRAPVFHPPIHHSLERKESSYSSLSPPTLTPVMPVNAGGKVQESQKPPTLIPEPKDSQSNFKNSSDQSLTEMWRSNNNLNREKAEWPVEKSSGKSQAAVASVIVRPPSSTKVDSVPSVPLASKDRVCERSSSGANKTDYLKPEAGETGRIILPNVNLESAHVKSEKNFEAVSQGNVPVSVMSAVNVVSTTKADVFTSAATTTSVSSLSSAETSYSLSNTISASTPFECTSSKSVVSQAVAQAKDCTVSTAVPGTLACSKTGSAVQPGSGFSGTTDFIHLKKHKAALAAAQFKNSSVSEAELNTVRNQTVAASLPLDSTMTCTASNKAISVGNGPAAQSSQPNYHTKLKKAWLTRHSEEDKNTNKMENSGNSVSEIIKPCSVNLIASTSNDIENRADGRVAVDKYGRDEKVSRRKAKRTYESGSESGDSDESESKSEQRTKRQPKPTYKKKQNDLQKRKGEVEEDSKPNGVLSRSAKDKSKLKLQNSNSAGVPRSVLKDWRKVKKLKQTGESFLQDDSCCEIGPNLQKCRECRLIRSKKGEESTHSPVFCRFYYFRRLSFSKNGVVRIDGFSSPDQYDDEAMSLWTHENYEDDEVDVETSKYILDIIGDKFCQLVTSEKTALSWVKKDAKIAWKRAVRGVREMCDACEATLFNVHWVCRKCGFVACLDCYKAKERKSSRDKELYAWMKCVKGQPHDHKHLMLTQIIPGSVLTDLLDAMHILREKYGIKSHCHCTNRQNLQGGNVPTMNGVSQVLQNVLHHSNKTSVSLPESQQQNSPQKSQTNGNSSPGSASTDSRLTPPESQSPLHWLADLAEQKSREEKQENKEFTLEREIKEDGDQDASDSPNGSTSPPASQSNEQGSTLRDLLTTTAGKLRVGSTDAGIAFAPVYSMGTSSGKGGRTMPNILDDIIASVVENKIPPNKTSKINIKSEPNEEPKESSLPATDESNKSYRDIPHSWICDQHILWLKDYKNSNNWKLFKECWKQGQPAVVSGVHKKMNISLWKAESISLDFGDHQADLLNCKDSIVSNANVKEFWDGFEEVSKRQKNKGGETVVLKLKDCPSGEDFKAMMPTRYEDFLRCLPLPEYCNPEGKFNLASHLPGFFVRPDLGPRLCSAYGVAAAKDHDIGTTNLHIEASDVVNVLVYVGIAKGNGVLSKAGILKKFEEEELDDVLRKRLKDSSEIPGALWHIYAGKDVDKIREFLQKISKEQGLEVLPEHDPIRDQSWYVNRKLRQRLLEEYGVRACTLIQFLGDAIVLPAGTLHQVQNFHSCVQVTEDFVSPEHLVQSFHLTQELRLLKEEINYDDKLQVKNILYHAVKEMVRALKMHEDEVEDMEDT
uniprot
proteins
ec_number
1.14.11.-
uniprot
proteins
function
FUNCTION: Demethylates lysine in proteins, such as STAT3 or MDC1 (By similarity) (PubMed:35995859). Demethylates MDC1, thereby promoting MDC1-RNF8 interaction and facilitating RNF8-dependent MDC1 ubiquitination essential for double-strand break (DSB) repair (By similarity). Demethylation of STAT3 at 'Lys-140', facilitates its interactions with the phosphatase PTPN6 and restrains STAT3 activation (PubMed:35995859). It is uncertain whether JMJD1C removes methyl groups from histone proteins as the other JMJD1/KDM3 proteins do (PubMed:20530532, PubMed:24006281, PubMed:32034158, PubMed:35995859). Nevertheless, JMJD1C may act as a context-specific histone demethylase. Implicated in lipogenic gene transcription in the liver, where USF1 recruits JMJD1C to lipogenic promoters in response to insulin or feeding stimuli, thereby potentially promoting H3K9me2 demethylation and enhancing chromatin accessibility (PubMed:32034158). Post-translational modifications may regulate JMJD1C's enzymatic activity, contributing to its context-specific functions (PubMed:32034158). Alternatively, JMJD1C may influence chromatin regulation indirectly, acting as a scaffold or co-regulator that recruits or stabilizes other active demethylase complexes modifying histone marks (By similarity). Plays an indispensable role in spermatogenesis (PubMed:20530532, PubMed:24006281). {ECO:0000250|UniProtKB:Q15652, ECO:0000269|PubMed:20530532, ECO:0000269|PubMed:24006281, ECO:0000269|PubMed:32034158, ECO:0000269|PubMed:35995859}.
uniprot
proteins
mass_dalton
281594
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Protein abundance of JMJD1C is regulated by the ubiquitin proteasome pathway. {ECO:0000250|UniProtKB:Q15652}.; PTM: Phosphorylated. Phosphorylation at Thr-505 by mTORC1 complex in response to insulin/feeding. {ECO:0000250|UniProtKB:Q15652}.
uniprot
proteins
protein_family
JHDM2 histone demethylase family
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20530532
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24006281
uniprot
proteins
pubmed
32034158
uniprot
proteins
pubmed
35995859
uniprot
proteins
sequence_length
2531
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q15652}.
uniprot
proteins