Fcho2
entrez
218503
canonical
uniprot
Q3UQN2
canonical
ensembl
ENSMUSG00000041685
resolver
ensp
ENSMUSP00000042959
resolver
genesymbol
Fcho2
resolver
uniprot
Q3UJ91
resolver
uniprot
Q7TMS9
resolver
uniprot
Q8C0I2
resolver
uniprot_entry
FCHO2_MOUSE
resolver
uniprot_sec
Q3UJ91
resolver
uniprot_sec
Q7TMS9
resolver
uniprot_sec
Q8C0I2
resolver
amino_acid_sequence
MVMAHFVENFWGEKNNGFDVLYHNMKHGQISTKELADFVRERATIEEAYSRSMTKLAKSASNYSQLGTFAPMWDVFKTSTEKLANCHLDLVRKLQELIKEVQKYGEEQVKSHKKTKEEVAGTLEAVQAIQNITQALQKSKENYTAKCVEQERLKKEGATQREIEKAAVKSKKATDTYKLYVEKYALTKADFEQKMTETAQKFQDIEETHLIHIKEIIGSLSNAVKEIHLQIGQVHEEFINNMANTTIESLIQKFAESKGTGKERPGLIEFEECDPASAVEGIKPRKRKTFALPGIIKKEKDAESVECPDADSLNIPDVDEEGFSIKPEANQNDTKENHFYSSSDSDSEDEEPKRYRIEIKPAHPNNLHHTMASLDELKVSIGNITLSPAVSRHSPVQMNRNSSNEELTKSKPSSLPTEKGTNDLLAWDPLFGSSLESSSAPLTSSSSARPTTPLSLGTLVPPPRPASRPKLASGKLSGINEIPRPFSPPVTSNTSPPPTAPLARAESSSSISSSASLSAANTPTVGVSRGPSPVSLGNQDTLPVAIALTESVNAYFKGADPTKCIVKITGDVTISFPSGIIKVFTSNPSPAVLCFRVKNISRLEQILPNSQLVFSDPSQCDSNTKDFWMNMQAVTIYLKKLSEQNPAASYYNVDVLKYQVSSNGIQSTPLNLATYWKCSASTTDLRVDYKYNPEAMVAPSVLSNIQVVVPVDGGVTNMQSLPPAIWNAEQMKAFWKLSGISEKSDSGGSGSLRAKFDLSEGPSKPTTLAVQFLSEGNTLSGVDIELVGTGYRLSLVKKRFATGRYLADC
uniprot
proteins
function
FUNCTION: Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a lipid-binding activity with a preference for membranes enriched in phosphatidylserine and phosphoinositides (Pi(4,5) biphosphate) like the plasma membrane. Its membrane-bending activity might be important for the subsequent action of clathrin and adaptors in the formation of clathrin-coated vesicles. Involved in adaptor protein complex AP-2-dependent endocytosis of the transferrin receptor, it also functions in the AP-2-independent endocytosis of the LDL receptor. {ECO:0000269|PubMed:21762413, ECO:0000269|PubMed:21883765}.
uniprot
proteins
mass_dalton
88734
uniprot
proteins
mutagenesis
MUTAGEN 38; /note="F->E: Loss of function mutant which is unable to promote clathrin coated-pits formation. Cytosolic mutant; when associated with E-73."; /evidence="ECO:0000269|PubMed:20448150"; MUTAGEN 73; /note="W->E: Loss of function mutant which is unable to promote clathrin coated-pits formation. Cytosolic mutant; when associated with E-38."; /evidence="ECO:0000269|PubMed:20448150"; MUTAGEN 136; /note="L->E: Loss of function mutant which is unable to promote clathrin coated-pits formation. Binds to membrane but is unable to induce membrane tubulation. Induces the formation of large and static clathrin-coated pits."; /evidence="ECO:0000269|PubMed:20448150"; MUTAGEN 146; /note="K->E: Loss of function mutant which is unable to promote clathrin coated-pits formation. Cytosolic mutant which is unable to bind and induce membrane tubulation; when associated with E-165."; /evidence="ECO:0000269|PubMed:20448150"; MUTAGEN 165; /note="K->E: Loss of function mutant which is unable to promote clathrin coated-pits formation. Cytosolic mutant which is unable to bind and induce membrane tubulation; when associated with E-146."; /evidence="ECO:0000269|PubMed:20448150"; MUTAGEN 268; /note="I->N: Loss of function mutant which is unable to promote clathrin coated-pits formation. Binds to membrane but is unable to induce membrane tubulation. Induces the formation of large and static clathrin-coated pits."; /evidence="ECO:0000269|PubMed:20448150"; MUTAGEN 797; /note="K->E: Loss of interaction with EPS15 and ITSN1."; /evidence="ECO:0000269|PubMed:20448150
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Mainly undergoes monoubiquitination but also polyubiquitination. {ECO:0000269|PubMed:21762413}.
uniprot
proteins
protein_family
FCHO family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
20448150
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21762413
uniprot
proteins
pubmed
21883765
uniprot
proteins
pubmed
22323290
uniprot
proteins
sequence_length
809
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane, clathrin-coated pit {ECO:0000305|PubMed:20448150, ECO:0000305|PubMed:21762413}; Peripheral membrane protein {ECO:0000305|PubMed:20448150, ECO:0000305|PubMed:21762413}; Cytoplasmic side {ECO:0000305|PubMed:20448150, ECO:0000305|PubMed:21762413}. Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2.
uniprot
proteins