CBR3
entrez
874
canonical
uniprot
O75828
canonical
ensembl
ENSG00000159231
resolver
ensp
ENSP00000290354
resolver
ensp
ENSP00000793326
resolver
enst
ENST00000290354
resolver
genesymbol
CBR3
resolver
genesymbol
HEL-S-25
resolver
genesymbol_syn
SDR21C2
resolver
hgnc
HGNC:1549
resolver
uniprot
Q6FHP2
resolver
uniprot
V9HW40
resolver
uniprot_entry
CBR3_HUMAN
resolver
uniprot_entry
V9HW40_HUMAN
resolver
uniprot_sec
Q6FHP2
resolver
amino_acid_sequence
MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDSIRTVEEGAETPVYLALLPPDATEPQGQLVHDKVVQNW
uniprot
proteins
ec_number
1.1.1.184
uniprot
proteins
ec_number
1.6.5.10
uniprot
proteins
function
FUNCTION: Catalyzes the NADPH-dependent reduction of carbonyl compounds to their corresponding alcohols (PubMed:18493841). Has low NADPH-dependent oxidoreductase activity. Acts on several orthoquinones, acts as well on non-quinone compounds, such as isatin or on the anticancer drug oracin (PubMed:15537833, PubMed:18493841, PubMed:19841672). Best substrates for CBR3 is 1,2- naphthoquinone, hence could play a role in protection against cytotoxicity of exogenous quinones (PubMed:19841672). Exerts activity toward ortho-quinones but not paraquinones. No endogenous substrate for CBR3 except isatin has been identified (PubMed:19841672). {ECO:0000269|PubMed:15537833, ECO:0000269|PubMed:18493841, ECO:0000269|PubMed:19841672}.
uniprot
proteins
mass_dalton
30850
uniprot
proteins
mutagenesis
MUTAGEN 142; /note="Q->M: Modest increase in carbonyl reductase (NADPH) activity toward 1,2-naphthoquinone."; /evidence="ECO:0000269|PubMed:19841672"; MUTAGEN 230; /note="P->F,W: Decreased carbonyl reductase (NADPH) activity toward 1,2-naphthoquinone and isatin."; /evidence="ECO:0000269|PubMed:19841672"; MUTAGEN 236; /note="D->A: Significant decreased of the Km value for isatin."; /evidence="ECO:0000269|PubMed:19841672
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
10830953
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15537833
uniprot
proteins
pubmed
18493841
uniprot
proteins
pubmed
19841672
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
9740676
uniprot
proteins
sequence_length
277
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18493841}.
uniprot
proteins