Trim50
entrez
288596
canonical
uniprot
Q810I1
canonical
ensembl
ENSRNOG00000022483
resolver
ensp
ENSRNOP00000036145
resolver
ensp
ENSRNOP00000110138
resolver
enst
ENSRNOT00000032250
resolver
enst
ENSRNOT00000145321
resolver
genesymbol
Trim50
resolver
uniprot
A0A0H2UHV0
resolver
uniprot
A0ABK0LZT2
resolver
uniprot
Q5U366
resolver
uniprot_entry
A0A0H2UHV0_RAT
resolver
uniprot_entry
A0ABK0LZT2_RAT
resolver
uniprot_entry
Q5U366_RAT
resolver
uniprot_entry
TRI50_RAT
resolver
amino_acid_sequence
MAWQLTVPELQDQLQCPICLEVFKEPLMLQCGHSYCKNCLDSLSEHLDSELRCPVCRQSVDCSSSPPNVSLARVIDALRLPGDTEPTVCVHHRNPLSLFCEKDQEFICGLCGLLGSHQHHRVTPVSTVYSRMKEELAGRLSELKEQHRDVEEHIGKLVNNRTRIINESDVFSWVIRREFQELHHLVDEEKARCLEGVESHTRGLVASLDMQLEQAQGTQERLAQAERVLEQFGNESHHEFIRFHSITSRGEVQQARPLEGVFSPISFKPALHQADIKLTVWKRLFRKVLPAPESLKLDPATAHPLLELSKGNTVVHCGLLAQRRASQPERFDYSTCVLASKGFSWGRHYWEVVVGSKSDWRLGVIKGTASRKGKLSKSPEHGVWLIGLKEGRLYEAFGCPRLPLPVAGHPHRIGVYLHYEQGELTFFDADRPDDLRALYTFQADFQGKLYPILDTCWHERGSNSLPMVLPPPSAPGHLTRAQV
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1. In turn, promotes starvation-induced autophagy activation. Also interacts with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction. Also promotes NLRP3 inflammasome activation by directly inducing NLRP3 oligomerization independent of its E3 ligase function (By similarity). {ECO:0000250|UniProtKB:Q86XT4}.
uniprot
proteins
mass_dalton
54719
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated. {ECO:0000250|UniProtKB:Q86XT4}.; PTM: Acetylated by EP300 and KAT2B. HDAC6 drives TRIM50 deacetylation. Acetylation antagonizes with TRIM50 ubiquitination. {ECO:0000250|UniProtKB:Q86XT4}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
sequence_length
483
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q86XT4}. Note=Localizes mainly into discrete cytoplasmic punctuate structures heterogeneous in size and shape containing polyubiquitinated proteins. {ECO:0000250|UniProtKB:Q86XT4}.
uniprot
proteins