Rnf20
entrez
109331
canonical
uniprot
Q5DTM8
canonical
ensembl
ENSMUSG00000028309
resolver
ensp
ENSMUSP00000029989
resolver
ensp
ENSMUSP00000128546
resolver
ensp
ENSMUSP00000351773
resolver
genesymbol
Rnf20
resolver
genesymbol_syn
Bre1a
resolver
genesymbol_syn
Kiaa4116
resolver
uniprot
A2AIR3
resolver
uniprot
Q3UT10
resolver
uniprot
Q3V350
resolver
uniprot
Q7TT11
resolver
uniprot
Q8BKA8
resolver
uniprot
Q8BKN8
resolver
uniprot
Q8BUF7
resolver
uniprot
Q8BVU4
resolver
uniprot_entry
BRE1A_MOUSE
resolver
uniprot_sec
A2AIR3
resolver
uniprot_sec
Q3UT10
resolver
uniprot_sec
Q3V350
resolver
uniprot_sec
Q7TT11
resolver
uniprot_sec
Q8BKA8
resolver
uniprot_sec
Q8BKN8
resolver
uniprot_sec
Q8BUF7
resolver
uniprot_sec
Q8BVU4
resolver
amino_acid_sequence
MSGIGNKRAAGEPGTSMPPEKKTAVEDSGTTVETIKLGGVSSTEELDIRTLQSKNRKLAEMLDQRQAIEDELREHIEKLERRQATDDASLLIVNRYWSQFDENIRIILKRYDLDQGLGDLLTERKALVVPEPEPDSDSNQERKDDRERGDGQEPAFSFLATLASSSSEEMESQLQERVESSRRAVSQIVTVYDKLQEKVDLLSRKLNSGDNLIVEEAVQELNSFLAQENVRLQELTDLLQEKHHTMSQEFCKLQGKVETAESRVSVLESMIDDLQWDIDKIRKREQRLNRHLAEVLERVNSKGYKVYGAGSSLYGGTITINARKFEEMNAELEENKELAQNRHCELEKLRQDFEEVTTQNEKLKVELRSAVEEVVKETPEYRCMQSQFSVLYNESLQLKAHLDEARTLLHGTRGTHQRQVELIERDEVSLHKKLRTEVIQLEDTLAQVRKEYEMLRIEFEQTLAANEQAGPINREMRHLISSLQNHNHQLKGEVLRYKRKLREAQSDLNKTRLRSGSALLQSQSSTEDPKDEPTELKQDSEDLATHSSALKASQEDEVKSKRDEEERERERREKEREREREREKEKEREREKQKLKESEKERDSVKDKEKGKHDDGRKKEAEIIKQLKIELKKAQESQKEMKLLLDMYRSAPKEQRDKVQLMAAEKKSKAELEDLRQRLKDLEDKEKKENKKMADEDALRKIRAVEEQIEYLQKKLAMAKQEEEALLSEMDVTGQAFEDMQEQNIRLMQQLREKDDANFKLMSERIKSNQIHKLLKEEKEELADQVLTLKTQVDAQLQVVRKLEEKEHLLQSNIGTGEKELGLRTQALEMNKRKAMEAAQLADDLKAQLELAQKKLHDFQDEIVENSVTKEKDLFNFKRAQEDISRLRRKLETTKKPDNVPKCDEILMEEIKDYKARLTCPCCNMRKKDAVLTKCFHVFCFECVKTRYDTRQRKCPKCNAAFGANDFHRIYIG
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1) (PubMed:28453857). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes. Recruited to the MDM2 promoter, probably by being recruited by p53/TP53, and thereby acts as a transcriptional coactivator. Mediates the polyubiquitination of PA2G4 leading to its proteasome-mediated degradation. {ECO:0000250|UniProtKB:Q5VTR2, ECO:0000269|PubMed:28453857}.
uniprot
proteins
mass_dalton
113520
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
BRE1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28453857
uniprot
proteins
sequence_length
973
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5VTR2}.
uniprot
proteins