LCLAT1
entrez
253558
canonical
uniprot
Q6UWP7
canonical
ensembl
ENSG00000172954
resolver
ensp
ENSP00000310551
resolver
ensp
ENSP00000368823
resolver
ensp
ENSP00000368826
resolver
ensp
ENSP00000567505
resolver
ensp
ENSP00000567508
resolver
ensp
ENSP00000591950
resolver
genesymbol
LCLAT1
resolver
genesymbol_syn
AGPAT8
resolver
genesymbol_syn
ALCAT1
resolver
genesymbol_syn
LYCAT
resolver
hgnc
HGNC:26756
resolver
uniprot
A6H8Z7
resolver
uniprot
B4DM26
resolver
uniprot
B4DYR5
resolver
uniprot
Q8N1Q7
resolver
uniprot_entry
B4DM26_HUMAN
resolver
uniprot_entry
B4DYR5_HUMAN
resolver
uniprot_entry
LCLT1_HUMAN
resolver
uniprot_sec
A6H8Z7
resolver
uniprot_sec
Q8N1Q7
resolver
amino_acid_sequence
MHSRGREIVVLLNPWSINEAVSSYCTYFIKQDSKSFGIMVSWKGIYFILTLFWGSFFGSIFMLSPFLPLMFVNPSWYRWINNRLVATWLTLPVALLETMFGVKVIITGDAFVPGERSVIIMNHRTRMDWMFLWNCLMRYSYLRLEKICLKASLKGVPGFGWAMQAAAYIFIHRKWKDDKSHFEDMIDYFCDIHEPLQLLIFPEGTDLTENSKSRSNAFAEKNGLQKYEYVLHPRTTGFTFVVDRLREGKNLDAVHDITVAYPHNIPQSEKHLLQGDFPREIHFHVHRYPIDTLPTSKEDLQLWCHKRWEEKEERLRSFYQGEKNFYFTGQSVIPPCKSELRVLVVKLLSILYWTLFSPAMCLLIYLYSLVKWYFIITIVIFVLQERIFGGLEIIELACYRLLHKQPHLNSKKNE
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
ec_number
2.3.1.51
uniprot
proteins
function
FUNCTION: Exhibits acyl-CoA:lysocardiolipin acyltransferase (ALCAT) activity; catalyzes the reacylation of lyso-cardiolipin to cardiolipin (CL), a key step in CL remodeling (By similarity). Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors (By similarity). Also exhibits 1-acyl-sn-glycerol-3-phosphate acyltransferase activity (AGPAT) activity; converts 1-acyl-sn-glycerol-3- phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3- phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (PubMed:16620771). Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities (PubMed:19075029). Required for establishment of the hematopoietic and endothelial lineages (By similarity). {ECO:0000250|UniProtKB:Q3UN02, ECO:0000269|PubMed:16620771, ECO:0000269|PubMed:19075029}.
uniprot
proteins
mass_dalton
48920
uniprot
proteins
mutagenesis
MUTAGEN 206; /note="D->C: Abolishes LPIAT and LPGAT activities."; /evidence="ECO:0000269|PubMed:16620771, ECO:0000269|PubMed:19075029"; MUTAGEN 206; /note="D->R: Does not increase enzyme activity."; /evidence="ECO:0000269|PubMed:16620771, ECO:0000269|PubMed:19075029"; MUTAGEN 207; /note="L->T: Abolishes LPIAT activity. No effect on LPGAT activity."; /evidence="ECO:0000269|PubMed:19075029
uniprot
proteins
pathway_participation
PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.
uniprot
proteins
protein_family
1-acyl-sn-glycerol-3-phosphate acyltransferase family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16620771
uniprot
proteins
pubmed
19075029
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21406692
uniprot
proteins
sequence_length
414
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19075029}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 47..67; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 86..106; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 340..360; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 362..382; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins