Tsc22d4
entrez
684980
canonical
uniprot
Q3B8N7
canonical
ensembl
ENSRNOG00000050805
resolver
ensembl
ENSRNOG00055000200
resolver
ensembl
ENSRNOG00060029917
resolver
ensembl
ENSRNOG00065000036
resolver
ensp
ENSRNOP00000033658
resolver
ensp
ENSRNOP00055000236
resolver
ensp
ENSRNOP00060043255
resolver
ensp
ENSRNOP00065000049
resolver
enst
ENSRNOT00000039280
resolver
enst
ENSRNOT00055000344
resolver
enst
ENSRNOT00060052006
resolver
enst
ENSRNOT00065000049
resolver
genesymbol
Tsc22d4
resolver
genesymbol_syn
Thg1-pit
resolver
uniprot_entry
T22D4_RAT
resolver
amino_acid_sequence
MSGGKKKSSFQITSVTTDYEGPGSPGASDPPAPPAPAGPPPRLPNGEPNPDPGGRGTPRNGSPPPGAPASRFRVVKLPQGLGEPYRRGRWTCVDVYERDLEPPSFGRLLEGIRGASGGTGGRSLDSRLELASLGISTPIPQPGLSQGPTSWLRPPPTSPGPQARSFTGGLGQLAGPGKAKVETPPLSASPPQQRPPGPGTGDSAQTLPSLRVEVESGGLAAGTPPLSRRRDGAVRLRMELVAPEETGKVPPIDSRPNSPALYFDASLVHKSPDPFGAAAAQSLSLARSMLAISGHLDSDDDSGSGSLVGIDNKIEQAMDLVKSHLMFAVREEVEVLKEQIRDLAERNAALEQENGLLRALASPEQLAQLPSSGLPRLGPSAPNGPSI
uniprot
proteins
function
FUNCTION: Binds DNA and acts as a transcriptional repressor (By similarity). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (By similarity). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3}.
uniprot
proteins
mass_dalton
40041
uniprot
proteins
protein_family
TSC-22/Dip/Bun family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
387
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9EQN3}. Cytoplasm {ECO:0000250|UniProtKB:Q9EQN3}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9EQN3}. Synapse {ECO:0000250|UniProtKB:Q9EQN3}. Note=Localizes away from the nucleus to neurite processes and synaptic termini as cerebellar granular neurons differentiate (By similarity). Accumulates in the cytoplasm of differentiated Purkinje cells (By similarity). Localized to both the cytoplasm and nucleus in immature cerebellar granular neurons and atrophic Purkinje cells (By similarity). {ECO:0000250|UniProtKB:Q9EQN3}.
uniprot
proteins