CA3
entrez
761
canonical
uniprot
P07451
canonical
ensembl
ENSG00000164879
resolver
ensp
ENSP00000285381
resolver
enst
ENST00000285381
resolver
genesymbol
CA3
resolver
hgnc
HGNC:1374
resolver
uniprot
B2R867
resolver
uniprot
B3KUC8
resolver
uniprot
O60842
resolver
uniprot_entry
CAH3_HUMAN
resolver
uniprot_sec
B2R867
resolver
uniprot_sec
B3KUC8
resolver
uniprot_sec
O60842
resolver
activity_regulation
ACTIVITY REGULATION: Activated by proton donors such as imidazole and the dipeptide histidylhistidine (PubMed:16042381). Inhibited by coumarins and sulfonamide derivatives such as acetazolamide (PubMed:19186056, PubMed:19206230). Inhibited by prontosil, sulpiride, indisulam, benzolamide, aminobenzolamide and 4-amino-6-chloro-benzene-1,3-disulfonamide (PubMed:17826101). {ECO:0000269|PubMed:16042381, ECO:0000269|PubMed:17826101, ECO:0000269|PubMed:19186056, ECO:0000269|PubMed:19206230}.
uniprot
proteins
amino_acid_sequence
MAKEWGYASHNGPDHWHELFPNAKGENQSPVELHTKDIRHDPSLQPWSVSYDGGSAKTILNNGKTCRVVFDDTYDRSMLRGGPLPGPYRLRQFHLHWGSSDDHGSEHTVDGVKYAAELHLVHWNPKYNTFKEALKQRDGIAVIGIFLKIGHENGEFQIFLDALDKIKTKGKEAPFTKFDPSCLFPACRDYWTYQGSFTTPPCEECIVWLLLKEPMTVSSDQMAKLRSLLSSAENEPPVPLVSNWRPPQPINNRVVRASFK
uniprot
proteins
ec_number
4.2.1.1
uniprot
proteins
function
FUNCTION: Reversible hydration of carbon dioxide. {ECO:0000269|PubMed:16042381, ECO:0000269|PubMed:17427958, ECO:0000269|PubMed:17826101, ECO:0000269|PubMed:19186056, ECO:0000269|PubMed:19206230}.
uniprot
proteins
mass_dalton
29557
uniprot
proteins
mutagenesis
MUTAGEN 64; /note="K->H: Enhanced proton transfer in catalysis."; /evidence="ECO:0000269|PubMed:17427958"; MUTAGEN 67; /note="R->H: Enhanced proton transfer in catalysis."; /evidence="ECO:0000269|PubMed:17427958"; MUTAGEN 197; /note="F->L: Enhanced activity by at least 10-fold."; /evidence="ECO:0000269|PubMed:16042381
uniprot
proteins
post_translational_modification
PTM: S-thiolated both by thiol-disulfide exchange with glutathione disulfide and by oxyradical-initiated S-thiolation with reduced glutathione. {ECO:0000250|UniProtKB:P14141}.; PTM: S-glutathionylated in hepatocytes under oxidative stress. {ECO:0000250|UniProtKB:P14141}.
uniprot
proteins
protein_family
Alpha-carbonic anhydrase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16042381
uniprot
proteins
pubmed
17427958
uniprot
proteins
pubmed
17826101
uniprot
proteins
pubmed
19186056
uniprot
proteins
pubmed
19206230
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2824285
uniprot
proteins
pubmed
3086182
uniprot
proteins
pubmed
3099285
uniprot
proteins
pubmed
9651514
uniprot
proteins
sequence_length
260
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:17826101}.
uniprot
proteins