Hsd3b7
entrez
246211
canonical
uniprot
O35048
canonical
ensembl
ENSRNOG00000019080
resolver
ensp
ENSRNOP00000091092
resolver
ensp
ENSRNOP00000102339
resolver
enst
ENSRNOT00000097840
resolver
enst
ENSRNOT00000162091
resolver
genesymbol
Hsd3b7
resolver
genesymbol_syn
Cca2
resolver
uniprot
A0A8I6APT0
resolver
uniprot
A0ABK0L1L7
resolver
uniprot_entry
3BHS7_RAT
resolver
uniprot_entry
A0A8I6APT0_RAT
resolver
uniprot_entry
A0ABK0L1L7_RAT
resolver
amino_acid_sequence
MADSAQVPALVYLVTGGCGFLGEHIVRMLLEWEPRLRELRVFDLHLSSWLEELKTGPVQVTAIQGDVTQAHEVAAAMAGSHVVIHTAGLVDVFGKASPETIHKVNVQGTQNVIDACVQTGTRLLVYTSSMEVVGPNVKGHPFYRGNEDTPYEAIHRHPYPCSKALAEQLVLEANGRKGLRFGGRLFRAIPASVEHGRVYVGNVAWMHILVARELEQRAALMGGQVYFCYDKSPYKSYEDFNMEFLSPCGLRLIGTHPLLPYWLLVLLTALNALLQWLLRPLVLYTPLLNPYTLAVANTTFTVSTNKAQRHFGYKPLFSWEESRARTIHWVQAMEGSAW
uniprot
proteins
ec_number
1.1.1.-
uniprot
proteins
ec_number
1.1.1.181
uniprot
proteins
function
FUNCTION: The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis. Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. {ECO:0000250|UniProtKB:Q9EQC1}.
uniprot
proteins
mass_dalton
37781
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; steroid biosynthesis. {ECO:0000250|UniProtKB:Q9H2F3}.
uniprot
proteins
protein_family
3-beta-HSD family
uniprot
proteins
pubmed
9199244
uniprot
proteins
sequence_length
338
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 258..278; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 280..300; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins