Nudt1
entrez
117260
canonical
uniprot
P53369
canonical
ensembl
ENSRNOG00000001260
resolver
ensembl
ENSRNOG00055011717
resolver
ensembl
ENSRNOG00060029637
resolver
ensembl
ENSRNOG00065000132
resolver
ensp
ENSRNOP00000001700
resolver
ensp
ENSRNOP00055016043
resolver
ensp
ENSRNOP00060042810
resolver
ensp
ENSRNOP00065000228
resolver
enst
ENSRNOT00055019902
resolver
enst
ENSRNOT00060051463
resolver
enst
ENSRNOT00065000229
resolver
genesymbol
Nudt1
resolver
genesymbol_syn
Mth1
resolver
uniprot_entry
8ODP_RAT
resolver
amino_acid_sequence
MSTSRLYTLVLVLQPQRVLLGMKKRGFGAGRWNGFGGKVQEGETIEDGAKRELLEESGLRVDTLHKVGHISFEFVGSPELMDVHIFSTDHVHGTPTESEEMRPQWFQLDQIPFADMWPDDSYWFPLLLQKKKFCGHFKFHGQDTILSYSLREVDEF
uniprot
proteins
ec_number
3.6.1.-
uniprot
proteins
ec_number
3.6.1.56
uniprot
proteins
function
FUNCTION: Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool (PubMed:7586133). Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP (PubMed:7586133). Also has a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP (By similarity). Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A (PubMed:7586133). Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA (PubMed:30304478, PubMed:32144205). Through this antimutagenic activity protects cells from oxidative stress (PubMed:30304478, PubMed:32144205, PubMed:7586133). {ECO:0000250|UniProtKB:P36639, ECO:0000269|PubMed:30304478, ECO:0000269|PubMed:32144205, ECO:0000269|PubMed:7586133}.
uniprot
proteins
mass_dalton
18018
uniprot
proteins
protein_family
Nudix hydrolase family
uniprot
proteins
pubmed
11817101
uniprot
proteins
pubmed
30304478
uniprot
proteins
pubmed
32144205
uniprot
proteins
pubmed
7586133
uniprot
proteins
sequence_length
156
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11817101}. Nucleus {ECO:0000269|PubMed:11817101}. Nucleus membrane {ECO:0000269|PubMed:11817101}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:11817101}.
uniprot
proteins