RAB9A
entrez
9367
canonical
uniprot
P51151
canonical
ensembl
ENSG00000123595
resolver
ensp
ENSP00000420127
resolver
ensp
ENSP00000480777
resolver
ensp
ENSP00000541568
resolver
ensp
ENSP00000541569
resolver
ensp
ENSP00000541570
resolver
ensp
ENSP00000592939
resolver
ensp
ENSP00000592940
resolver
ensp
ENSP00000592941
resolver
ensp
ENSP00000592942
resolver
ensp
ENSP00000592943
resolver
ensp
ENSP00000592944
resolver
ensp
ENSP00000592945
resolver
ensp
ENSP00000625291
resolver
ensp
ENSP00000625292
resolver
enst
ENST00000464506
resolver
enst
ENST00000618931
resolver
enst
ENST00000871509
resolver
enst
ENST00000871510
resolver
enst
ENST00000871511
resolver
enst
ENST00000922880
resolver
enst
ENST00000922881
resolver
enst
ENST00000922882
resolver
enst
ENST00000922883
resolver
enst
ENST00000922884
resolver
enst
ENST00000922885
resolver
enst
ENST00000922886
resolver
enst
ENST00000955232
resolver
enst
ENST00000955233
resolver
genesymbol
RAB9A
resolver
genesymbol_syn
RAB9
resolver
hgnc
HGNC:9792
resolver
uniprot
A8K390
resolver
uniprot
Q6ICN1
resolver
uniprot_entry
RAB9A_HUMAN
resolver
uniprot_sec
A8K390
resolver
uniprot_sec
Q6ICN1
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MAGKSSLFKVILLGDGGVGKSSLMNRYVTNKFDTQLFHTIGVEFLNKDLEVDGHFVTMQIWDTAGQERFRSLRTPFYRGSDCCLLTFSVDDSQSFQNLSNWKKEFIYYADVKEPESFPFVILGNKIDISERQVSTEEAQAWCRDNGDYPYFETSAKDATNVAAAFEEAVRRVLATEDRSDHLIQTDTVNLHRKPKPSSSCC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB9A is involved in the transport of proteins between the endosomes and the trans-Golgi network (TGN) (PubMed:34793709). Specifically uses NDE1/NDEL1 as an effector to interact with the dynein motor complex in order to control retrograde trafficking of RAB9-associated late endosomes to the TGN (PubMed:34793709). Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). {ECO:0000250|UniProtKB:P24408, ECO:0000250|UniProtKB:P62820, ECO:0000269|PubMed:34793709}.
uniprot
proteins
mass_dalton
22838
uniprot
proteins
mutagenesis
MUTAGEN 40; /note="I->L: Loss of interaction with HPS4; when associated with L-66."; /evidence="ECO:0000269|PubMed:20048159"; MUTAGEN 40; /note="I->R: Loss of interaction with NDE1 and the dynein complex. Loss of localization to intracellular membrane vesicles."; /evidence="ECO:0000269|PubMed:34793709"; MUTAGEN 43; /note="E->A: Decreased interaction with NDE1."; /evidence="ECO:0000269|PubMed:34793709"; MUTAGEN 44; /note="F->D: Loss of interaction with NDE1 and the dynein complex. Loss of localization to intracellular membrane vesicles."; /evidence="ECO:0000269|PubMed:34793709"; MUTAGEN 44; /note="F->L: Loss of interaction with HPS4; when associated with L-66."; /evidence="ECO:0000269|PubMed:20048159"; MUTAGEN 46; /note="N->A,I,S,T,V: Loss of interaction with NDE1."; /evidence="ECO:0000269|PubMed:34793709"; MUTAGEN 61; /note="W->D: Loss of interaction with NDE1. No change in localization to intracellular membrane vesicles."; /evidence="ECO:0000269|PubMed:34793709"; MUTAGEN 61; /note="W->L: Loss of interaction with HPS4; when associated with L-66."; /evidence="ECO:0000269|PubMed:20048159"; MUTAGEN 66; /note="Q->L: Loss of interaction with HPS4; when associated with L-40 or L-44 or L-61."; /evidence="ECO:0000269|PubMed:20048159"; MUTAGEN 72; /note="L->D: Loss of interaction with NDE1 and the dynein complex. Loss of localization to intracellular membrane vesicles."; /evidence="ECO:0000269|PubMed:34793709
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15263003
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16176980
uniprot
proteins
pubmed
16885419
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18243103
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20048159
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21255211
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21808068
uniprot
proteins
pubmed
22637480
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
34793709
uniprot
proteins
pubmed
9126495
uniprot
proteins
sequence_length
201
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}. Golgi apparatus membrane {ECO:0000305|PubMed:34793709}. Late endosome {ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:34793709}. Cytoplasmic vesicle, phagosome membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21255211}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:34793709}. Melanosome {ECO:0000250|UniProtKB:Q9R0M6}. Note=Colocalizes with OSBPL1A at the late endosome (PubMed:16176980). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). Mainly localizes to late endosomes and partially localizes to Golgi (PubMed:34793709). Colocalizes with NDE1 to membrane vesicles (PubMed:34793709). {ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:21255211, ECO:0000269|PubMed:34793709}.
uniprot
proteins