Plekho1
entrez
67220
canonical
uniprot
Q9JIY0
canonical
ensembl
ENSMUSG00000015745
resolver
ensp
ENSMUSP00000015889
resolver
ensp
ENSMUSP00000188238
resolver
enst
ENSMUST00000015889
resolver
genesymbol
Plekho1
resolver
uniprot
Q9CXH2
resolver
uniprot_entry
PKHO1_MOUSE
resolver
uniprot_sec
Q9CXH2
resolver
amino_acid_sequence
MKKSGSGKRGPPDGNHQSAAPEKVGWVRKFCGKGIFREIWKNRYVVLKGDQLYVSEKEVKDEKNSQEVFDLSDYEKCEELRKSKSRSKKNHSKFTLARCRQPGTTAPNLIFLAVSPEEKESWINALSSAITRAKNRILDEVTVEEDSYLAHPTRDRAKIQHSRRPPTRGHLMAVASTSTSDGMLTLDLIQEEDPSPEEPASCAESFRVDLDKSVAQLAGSRRRADSDRIQPSSQRASSLSRPWEKPDKGAPYTPQALKKFPSTEKSRCASLEEILSQRDTAPARPLHLQAEESLPPVPAQPGQLSRIQDLVARKLEKTQELLAEVQGLGDGKRKAKDPPQSPPDSESEQLLLETERLLGEASSNWSQAKRVLQEVRELRDLYRQMDLQTPDSHLRQTSQHSQYRKSLM
uniprot
proteins
function
FUNCTION: Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation (By similarity). {ECO:0000250, ECO:0000269|PubMed:17942896}.
uniprot
proteins
mass_dalton
45997
uniprot
proteins
post_translational_modification
PTM: C-terminal fragments could be released during apoptosis via caspase-3-dependent cleavage. {ECO:0000250}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17942896
uniprot
proteins
pubmed
19144319
uniprot
proteins
sequence_length
408
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q53GL0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q53GL0}. Nucleus {ECO:0000250|UniProtKB:Q53GL0}. Cytoplasm {ECO:0000250|UniProtKB:Q53GL0}. Note=Predominantly localized to the plasma membrane through the binding to phosphatidylinositol 3-phosphate. In C2C12 cells, with the absence of growth factor, it is found in the nucleus. It rapidly translocates to the plasma membrane after insulin stimulation. In response to TNF, it translocates from the plasma membrane to the cytoplasm and then to the nucleus accompanied by cleavage by caspase-3. However, the subcellular location is highly dependent of the cell type, and this explains why it is found exclusively at the plasma membrane, in some type of cells. {ECO:0000250|UniProtKB:Q53GL0}.
uniprot
proteins