Fzd2
entrez
57265
canonical
uniprot
Q9JIP6
canonical
ensembl
ENSMUSG00000050288
resolver
ensp
ENSMUSP00000091463
resolver
enst
ENSMUST00000057893
resolver
genesymbol
Fzd2
resolver
genesymbol_syn
Fzd10
resolver
uniprot
Q810M0
resolver
uniprot
Q9JIP5
resolver
uniprot
Q9WUJ2
resolver
uniprot_entry
FZD2_MOUSE
resolver
uniprot_sec
Q810M0
resolver
uniprot_sec
Q9JIP5
resolver
uniprot_sec
Q9WUJ2
resolver
amino_acid_sequence
MRARSALPRSALPRLLLPLLLLPAAGPAQFHGEKGISIPDHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSEDGAPALLTTAPPSGLQPGAGGTPGGPGGGGSPPRYATLEHPFHCPRVLKVPSYLSYKFLGERDCAAPCEPARPDGSMFFSQEETRFARLWILTWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAGFVLQERVVCNERFSEDGYRTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERSWVSQHCKSLAIPCPAHYTPRMSPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTRLTNSRHGETTV
uniprot
proteins
function
FUNCTION: Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. {ECO:0000250|UniProtKB:Q14332}.
uniprot
proteins
mass_dalton
64059
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. {ECO:0000250}.
uniprot
proteins
protein_family
G protein-coupled receptor Fz/Smo family
uniprot
proteins
pubmed
10903145
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
570
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 253..273; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 285..305; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 333..353; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 376..396; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 420..440; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 467..487; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 525..545; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins