Topors
entrez
106021
canonical
uniprot
Q80Z37
canonical
ensembl
ENSMUSG00000036822
resolver
ensp
ENSMUSP00000046843
resolver
ensp
ENSMUSP00000191786
resolver
enst
ENSMUST00000042575
resolver
genesymbol
Topors
resolver
uniprot
Q3U5B5
resolver
uniprot
Q3UPZ1
resolver
uniprot
Q3USN3
resolver
uniprot
Q3UZ55
resolver
uniprot
Q8BXP2
resolver
uniprot
Q8CFF5
resolver
uniprot
Q8CGC8
resolver
uniprot
Q920L3
resolver
uniprot_entry
TOPRS_MOUSE
resolver
uniprot_sec
Q3U5B5
resolver
uniprot_sec
Q3UPZ1
resolver
uniprot_sec
Q3USN3
resolver
uniprot_sec
Q3UZ55
resolver
uniprot_sec
Q8BXP2
resolver
uniprot_sec
Q8CFF5
resolver
uniprot_sec
Q8CGC8
resolver
uniprot_sec
Q920L3
resolver
amino_acid_sequence
MGSQPPPPGSPLSREEGEAPPLVPAEEGRRRSRRVRLRGSCRHRPSLLSRRELASNGPAVPATASSEIMASAAKEFKMDNFSPKAGTSKLQQTVPADASPDSKCPICLDRFDNVSYLDRCLHKFCFRCVQEWSKNKAECPLCKQPFDSIFHSVRAEDDFKEYVLRPSYNGSFTNPEVRRFRYRTTMTRERSASLYSPSSTVSRRTTTPPDSGVLFEGLGISTRPRDVDIPQFMRQMALRGPTTTDERSLRKIQEQDIINFRRTLYRAGVRVRSIEDGGRYRDISAEFFRRNPACLHRLVPWLKRELTVLFGAHGSLVNIVQHIIMSNVTRYDLESQAFVSDLRPFLLNRTEHFIHEFISFARSPFNMAAFDQHANYDCPPSSEEGSRSDSSVITISPDEAETQELDMNASTVRQAPWDDETPGPSYSSSEQVHVGVSSLLNSSDSSDEELVSGGTTSQIQGVQTNDDVNNDSDSSSDNCVIVGFVKPLAERTPELVELSSDSEELGPYEKVETVKTQEQEQSYSSGDSDVSRASSPRSVLGKDEQMSKSHCDSDTRISSKKEEKRSTSLPAPRDSSSTRGDRVCSPYNHRHRKGGRSRSSDSRSQSRSGHDPRNHRKHGKKRLRNKRSRSRESSSRPRARKDKKRSRTRDSSWSRRSQTLSLSSGSTSRSRSRSSDHGKRRSRSRNRDRYYLRNNYGSKYKWEYTYYSRNKDRDGYESSYRRRTLSRAHYSRQSSSPEFRIQSFSERTNARKKNHSERKYYYYERRRSRSVSSNRSRTTSAGPDRVRNEKPGGKRKYKTRHLEGTSEEAQPAREFTSKGKDSHYQKSKLDGSYKNESDSFSDSRSSDRETKHKRRRRRTRSLSVEIVYEGKATDTSKHHKKKKKKHKKKHKKHHGDNTSRSPVVITIDSDSDGESEVKAGIECSNGSLPQPIQDGAFETKDVVTIEDELGVLDKDCDVTALADDLSTSQTVENCDSPAVPVEQTLDVREESTFASDLESQSSNVSIQAEPSRPVPSPRTSLSSVSPGRDCDVS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Functions as an E3 ubiquitin-protein ligase and as a E3 SUMO1-protein ligase. Probable tumor suppressor involved in cell growth, cell proliferation and apoptosis that regulates p53/TP53 stability through ubiquitin-dependent degradation. May regulate chromatin modification through sumoylation of several chromatin modification-associated proteins. May be involved in DNA-damage-induced cell death through IKBKE sumoylation. {ECO:0000269|PubMed:15703819, ECO:0000269|PubMed:15735665}.
uniprot
proteins
mass_dalton
117082
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-99 regulates the E3 ubiquitin-protein ligase activity but not the SUMO1-protein ligase activity. Phosphorylation at Ser-718 increases the E3 ubiquitin-protein ligase activity versus the E3 SUMO1-protein ligase activity resulting in increased p53/TP53 ubiquitination and degradation. {ECO:0000250|UniProtKB:Q9NS56}.; PTM: Sumoylated. {ECO:0000250|UniProtKB:Q9NS56}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15703819
uniprot
proteins
pubmed
15735665
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1033
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15703819, ECO:0000269|PubMed:15735665}. Nucleus, PML body {ECO:0000250|UniProtKB:Q9NS56}. Note=Localizes to discrete nuclear foci which partly overlap with PML nuclear bodies. Targeted to PML nuclear bodies upon DNA damage. {ECO:0000250|UniProtKB:Q9NS56}.
uniprot
proteins