Anxa2
entrez
12306
canonical
uniprot
P07356
canonical
ensembl
ENSMUSG00000032231
resolver
ensp
ENSMUSP00000034756
resolver
ensp
ENSMUSP00000358111
resolver
enst
ENSMUST00000034756
resolver
genesymbol
Anxa2
resolver
genesymbol_syn
Anx2
resolver
genesymbol_syn
Cal1h
resolver
uniprot
Q542G9
resolver
uniprot_entry
ANXA2_MOUSE
resolver
uniprot_entry
Q542G9_MOUSE
resolver
amino_acid_sequence
MSTVHEILCKLSLEGDHSTPPSAYGSVKPYTNFDAERDALNIETAVKTKGVDEVTIVNILTNRSNVQRQDIAFAYQRRTKKELPSALKSALSGHLETVILGLLKTPAQYDASELKASMKGLGTDEDSLIEIICSRTNQELQEINRVYKEMYKTDLEKDIISDTSGDFRKLMVALAKGRRAEDGSVIDYELIDQDARELYDAGVKRKGTDVPKWISIMTERSVCHLQKVFERYKSYSPYDMLESIKKEVKGDLENAFLNLVQCIQNKPLYFADRLYDSMKGKGTRDKVLIRIMVSRSEVDMLKIRSEFKRKYGKSLYYYIQQDTKGDYQKALLYLCGGDD
uniprot
proteins
function
FUNCTION: Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response (By similarity). Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9 (PubMed:22848640). Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation (PubMed:22453828). Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis (PubMed:14702107). {ECO:0000250|UniProtKB:P07355, ECO:0000269|PubMed:14702107, ECO:0000269|PubMed:22453828, ECO:0000269|PubMed:22848640}.; FUNCTION: (Microbial infection) Regulates the formation of the NLRC4 inflammasome triggered by Anaplasma phagocytophilum infection. {ECO:0000269|PubMed:27045038}.; FUNCTION: (Microbial infection) Protects against Klebsiella pneumoniae infection (PubMed:26527544). Attenuates bacteria-induced pulmonary inflammation and promotes intro-abdominal pathogen clearance (PubMed:26527544). Promotes anti-inflammatory responses by facilitating TLR4 internalization and translocation into early endosomal membranes; this leads to activation of TRAM-dependent endosomal signaling and release of anti-inflammatory cytokines (PubMed:26527544). {ECO:0000269|PubMed:26527544}.; FUNCTION: (Microbial infection) Promotes macrophage phagocytic efficiency towards Cryptococcus neoformans and ability to control fungal infection inside the cells. {ECO:0000269|PubMed:27371724}.; FUNCTION: (Microbial infection) Contributes to protection against Pseudomonas aeruginosa infection by regulating autophagy via the AKT1-mTOR-ULK1/2 signaling pathway and activation of Rho GTPases via FAM13A-mediated mechanism. {ECO:0000269|PubMed:26371245}.
uniprot
proteins
mass_dalton
38676
uniprot
proteins
post_translational_modification
PTM: ISGylated. {ECO:0000269|PubMed:16139798}.
uniprot
proteins
protein_family
Annexin family
uniprot
proteins
pubmed
14506282
uniprot
proteins
pubmed
14702107
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16139798
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2138915
uniprot
proteins
pubmed
21645192
uniprot
proteins
pubmed
22453828
uniprot
proteins
pubmed
22848640
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
26371245
uniprot
proteins
pubmed
26527544
uniprot
proteins
pubmed
27045038
uniprot
proteins
pubmed
27371724
uniprot
proteins
pubmed
3013423
uniprot
proteins
pubmed
8634333
uniprot
proteins
sequence_length
339
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. Melanosome {ECO:0000250}. Note=In the lamina beneath the plasma membrane.; SUBCELLULAR LOCATION: Early endosome {ECO:0000269|PubMed:26527544}. Note=(Microbial infection) In lipopolysaccharide (LPS)-triggered macrophages, aggregates as clusters along the cytoplasmic side of the membrane, shows substantially enhanced co-localization with TLR4 signalosome complex and gets recruited to early endosomes. {ECO:0000269|PubMed:26527544}.
uniprot
proteins