Adcy10
entrez
59320
canonical
uniprot
Q9Z286
canonical
ensembl
ENSRNOG00000053410
resolver
ensembl
ENSRNOG00055017594
resolver
ensembl
ENSRNOG00060009857
resolver
ensembl
ENSRNOG00065019680
resolver
ensp
ENSRNOP00000072356
resolver
enst
ENSRNOT00000082677
resolver
genesymbol
Adcy10
resolver
genesymbol_syn
Sac
resolver
uniprot_entry
ADCYA_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by manganese or magnesium ions (PubMed:9874775). In the presence of magnesium ions, the enzyme is activated by bicarbonate (PubMed:12609998). Calcium mildly increases the enzyme activity, also in the presence of magnesium ions. {ECO:0000250|UniProtKB:Q96PN6, ECO:0000269|PubMed:12609998, ECO:0000269|PubMed:9874775}.
uniprot
proteins
amino_acid_sequence
MSARRQELQDRAIVKIAAHLPDLIVYGDFSPERPSVKCFDGVLMFVDISGFTAMTEKFSTAMYMDRGAEQLVEILNYYISAIVEKVLIFGGDILKFAGDALLALWKVERKQLKNIITVVIKCSLEIHGLFEAKEVEEGLDIRVKIGLAAGHITMLVFGDETRNYFLVIGQAVDDVRLAQNMAQMNDVILSPNCWQLCDRSMIEIERIPDQRAVKVSFLKPPPTFNFDEFFAKCMAFMDYYPSGDHKNFLRLACMLESDPELELSLQKYVMEIILKQIDDKQLRGYLSELRPVTIVFVNLMFKEQDKAEVIGSAIQAACVHITSVLKVFRGQINKVFMFDKGCSFLCVFGFPGEKAPDEITHALESAVDIFDFCSQVHKIRTVSIGVASGIVFCGIVGHTVRHEYTVIGQKVNIAARMMMYYPGIVTCDSVTYDGSNLPAYFFKELPKKVMKGVADPGPVYQCLGLNEKVMFGMAYLICNRYEGYPLLGRVREIDYFMSTMKDFLMTNCSRVLMYEGLPGYGKSQVLMEIEYLASQHENHRAVAIALTKISFHQNFYTIQILMANVLGLDTCKHYKERQTNLQNRVKTLLDDKYHCLLNDIFHVQFPVSREMSRMSKIRKQKQLEALFMKILEQTVREERIIFIIDEAQFVDVASWAFIEKLIRSMPIFIVMSLCPFPETPCAAANAIMKNRNTTYITLGTMQPQEIRDKVCVDLSVSSIPRELDSYLVEGSCGIPYYCEELLKNLDHHRILIFQQAEAEEKTNVTWNNLFKYSVKPTEDMYLYTSIAAGQKEACYLTSGVRLKNLSPPASLKEISLVQLDSMSLSHQMLVRCAAIIGLTFTTELLFEILPCWNMKMMIKALATLVESNVFDCFRSSKDLQLALKQNVTTFEVHYRSLSLKSKEGLAYSEEEQLREMEGEVIECRILRFCRPIMQKTAYELWLKDQKKVLHLKCARFLEESAHRCNHCRNRDFIPYHHFIADIRLNTLDMDTVKKMVKSHGFKTEDEVIFSKSEIPRKFKFPENISITETREKILHFFDNVIIKMRTSQDDVIPLESCHCEELLQIVILPLAQHFVALEENNKALYYFLELASAYLILGDNYNAYMYLGEGERLLKSLTNEDSWSQTFEYATFYSLKGEICFNMGQMVLAKKMLRKALKLLNRMFPCNLLSLTFQMHIEKNRLSHFMNQHTQEGSLPGKKLAQLFLQSSCFSLLWKIYSLNFFFHYKYYGRLAAIMQMNTSLETQNNFQIIKAFLDFSLYRHLAGYEGVWFKYEILVMEQLLNLPLKGEAFEIMAYAADALGHIKFLTGHLDLAIELGSRAHKMWSLLRNPNKYHMVLCRLSKPLFLKSRYKHLVQVLGWLWDLSVTEEHIFSKAFFYFVCLDIMLYSGFIYRTFEECLEFIHHNEDNRILKFQSGLLLGLYSCIAVWYARLQEWDNFYKFSNRAKTLVTRRTPTVLYYEGISRYMEGQVLHLQKQIEEQAENAQDSGVELLKALETLVAQNTTGPVFYPRLYHLMAYVCILMGDGHSCDFFLNTALELSETQGNLLEKCWLSMSKEWWYSAPELTGDQWLQTVLSLPSWDKIVSGNVTLQDVQKNKFLMRVNILDNPF
uniprot
proteins
ec_number
4.6.1.1
uniprot
proteins
function
FUNCTION: Catalyzes the formation of the signaling molecule cAMP (PubMed:9874775). May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (By similarity). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (By similarity). {ECO:0000250|UniProtKB:Q8C0T9, ECO:0000250|UniProtKB:Q96PN6, ECO:0000269|PubMed:9874775}.
uniprot
proteins
mass_dalton
185854
uniprot
proteins
post_translational_modification
PTM: Cleavage may occur to generate the active 48 kDa form. {ECO:0000305|PubMed:9874775}.
uniprot
proteins
protein_family
Adenylyl cyclase class-4/guanylyl cyclase family
uniprot
proteins
pubmed
11423534
uniprot
proteins
pubmed
12475901
uniprot
proteins
pubmed
12609998
uniprot
proteins
pubmed
9874775
uniprot
proteins
sequence_length
1608
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q96PN6}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q96PN6}; Cytoplasmic side {ECO:0000250|UniProtKB:Q96PN6}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q96PN6}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q96PN6}. Nucleus {ECO:0000269|PubMed:12475901}. Cell projection, cilium {ECO:0000250|UniProtKB:Q96PN6}. Cytoplasm {ECO:0000269|PubMed:9874775}. Mitochondrion {ECO:0000269|PubMed:12475901}. Note=Distributed to subcellular compartments containing cAMP targets. Found as a plasma membrane-associated protein, protein concentrated in the perinuclear region and protein colocalized with actin or tubulin. {ECO:0000250|UniProtKB:Q96PN6}.
uniprot
proteins