Gmppb
entrez
331026
canonical
uniprot
Q8BTZ7
canonical
ensembl
ENSMUSG00000070284
resolver
ensp
ENSMUSP00000036898
resolver
ensp
ENSMUSP00000107914
resolver
enst
ENSMUST00000047947
resolver
enst
ENSMUST00000112295
resolver
genesymbol
Gmppb
resolver
uniprot_entry
GMPPB_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Enzyme activity is reduced by incorporation into the GMPPA-GMPPB mannose-1-phosphate guanylyltransferase complex. Allosterically inhibited, when part of the GMPPA-GMPPB complex, by GDP-alpha-D-mannose binding to GMPPA. {ECO:0000250|UniProtKB:Q9Y5P6}.
uniprot
proteins
amino_acid_sequence
MKALILVGGYGTRLRPLTLSTPKPLVDFCNKPILLHQVEALAAAGVDHVILAVSYMSQMLEKEMKAQEQRLGIRISMSHEEEPLGTAGPLALARDLLSETADPFFVLNSDVICDFPFQAMVQFHRHHGQEGSILVTKVEEPSKYGVVVCEADTGRIHRFVEKPQVFVSNKINAGMYILSPAVLQRIQLKPTSIEKEIFPVMAKEGQLYAMELQGFWMDIGQPKDFLTGMCLFLQSLRQKHPERLYSGPGIVGNVLVDPSARIGQNCSIGPNVSLGPGVVVEDGVCIRRCTVLRDAHIRSHSWLESCIVGWRCRVGQWVRMENVTVLGEDVIVNDELYLNGASVLPHKSIGESVPEPRIIM
uniprot
proteins
ec_number
2.7.7.13
uniprot
proteins
function
FUNCTION: Catalytic subunit of the GMPPA-GMPPB mannose-1-phosphate guanylyltransferase complex (By similarity). Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids (By similarity). Can catalyze the reverse reaction in vitro (By similarity). Together with GMPPA regulates GDP-alpha-D-mannose levels (By similarity). {ECO:0000250|UniProtKB:P0C5I2, ECO:0000250|UniProtKB:Q9Y5P6}.
uniprot
proteins
mass_dalton
39917
uniprot
proteins
pathway_participation
PATHWAY: Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1. {ECO:0000250|UniProtKB:P0C5I2}.
uniprot
proteins
protein_family
Transferase hexapeptide repeat family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
360
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Y5P6}.
uniprot
proteins