Atp12a
entrez
192113
canonical
uniprot
Q9Z1W8
canonical
ensembl
ENSMUSG00000022229
resolver
ensp
ENSMUSP00000007340
resolver
enst
ENSMUST00000007340
resolver
genesymbol
Atp12a
resolver
genesymbol_syn
Atp1al1
resolver
uniprot
Q32MR8
resolver
uniprot
Q8VHY2
resolver
uniprot_entry
AT12A_MOUSE
resolver
uniprot_sec
Q32MR8
resolver
uniprot_sec
Q8VHY2
resolver
amino_acid_sequence
MRRKTEIYSVELNGTKDVELADQKDDKKFKGGKNKDSEPNKSQEEELKKELDLDDHRLSNTDLEQKYGTNIIQGLSSIRAAELLARDGPNALTPPKQTPEIIKFLKQMVGGFSILLWIGAALCWIAYVIQYVSSTASLDNVYLGAILVLVVILTGIFAYYQEAKSTNIMASFSKMIPQQALVIRDAEKKIIPAEQLVVGDVVEIKGGDQIPADIRLVFSQGCKVDNSSLTGESEPQARSTEFTHENPLETKNIGFYSTTCLEGTATGIVINTGDRTIIGRIASLASGVGSEKTPIAIEIEHFVHIVAAVAVSVGVIFFITAVCMKYYVLDAIIFLISIIVANVPEGLLATVTVTLSLTAKRMAKKNCLVKNLEAVETLGSTSIICSDKTGTLTQNRMTVAHLWFDNQIFVADTSENQTKQAFDQSSGTWASLSKIITLCNRAEFRPGQESVPIMKRVVVGDASETALLKFSEVILGDVMDIRKRNHKVAEIPFNSTNKFQLSIHETEDPNDKRFLMVMKGAPERILEKCSTIMINGQEQPLDKSSADAFHTAYMELGGLGERVLGFCHLYLPADKFPQSYTFDVDSINFPTSNLCFVGLLSMIDPPRSTVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKSVGIISANNETVEDIAKRRNIAVEQVNKREAKAAVVTGMELKDMTPEQLDELLINYQEIVFARTSPQQKLIIVEGCQRQDAVVAVTGDGVNDSPALKKADIGIAMGIAGSDAAKNAADMVLLDDNFASIVTGVEEGRLIFDNLKKTIAYTLTKNIAELCPFLIYIVAGLPLPIGTITILFIDLGTDIIPSIALAYEKAESDIMNRKPRHKKKDRLVNKQLAIYSYLHIGLMQALGGFLVYFTVYAQQGFWPTSLINLRVSWETDDINDLEDSYGQEWTRYQRKYLEWTGSTAFFVAIMVQQIADLIIRKTRRNSIFQQGLFRNKVIWVGIISQIIVALVLSYGLGSVTALSFTMLRAQYWFVAVPHAILIWVYDEMRKLFIRLYPGSWWDKNMYY
uniprot
proteins
ec_number
7.2.2.13
uniprot
proteins
ec_number
7.2.2.19
uniprot
proteins
function
FUNCTION: The catalytic subunit of a H(+)/K(+) ATPase and/or Na(+)/K(+) ATPase pump which transports K(+) ions in exchange for Na(+) and/or H(+) ions across the apical membrane of epithelial cells. Uses ATP as an energy source to pump K(+) ions into the cell while transporting Na(+) and/or H(+) ions to the extracellular compartment (By similarity). Involved in the maintenance of electrolyte homeostasis through K(+) ion absorption in kidney and colon (PubMed:9449685). In the airway epithelium, may play a primary role in mucus acidification regulating its viscosity and clearance (By similarity). {ECO:0000250|UniProtKB:P54707, ECO:0000269|PubMed:9449685}.
uniprot
proteins
mass_dalton
114727
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type IIC subfamily
uniprot
proteins
pubmed
11729223
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9449685
uniprot
proteins
pubmed
9872395
uniprot
proteins
sequence_length
1035
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:P54707, ECO:0000250|UniProtKB:P54708}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 100..120; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 143..163; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 300..319; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 332..349; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 784..803; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 814..834; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 855..877; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 930..949; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 964..982; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 998..1018; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins