CCP110
entrez
9738
canonical
uniprot
O43303
canonical
ensembl
ENSG00000103540
resolver
ensp
ENSP00000370803
resolver
ensp
ENSP00000379515
resolver
ensp
ENSP00000511625
resolver
ensp
ENSP00000571599
resolver
ensp
ENSP00000595983
resolver
ensp
ENSP00000595984
resolver
ensp
ENSP00000595985
resolver
ensp
ENSP00000662053
resolver
genesymbol
CCP110
resolver
genesymbol_syn
CEP110
resolver
genesymbol_syn
CP110
resolver
genesymbol_syn
KIAA0419
resolver
hgnc
HGNC:24342
resolver
uniprot
B7WP23
resolver
uniprot
O43335
resolver
uniprot
Q68DV9
resolver
uniprot
Q8NE13
resolver
uniprot_entry
CP110_HUMAN
resolver
uniprot_sec
B7WP23
resolver
uniprot_sec
O43335
resolver
uniprot_sec
Q68DV9
resolver
uniprot_sec
Q8NE13
resolver
amino_acid_sequence
MEEYEKFCEKSLARIQEASLSTESFLPAQSESISLIRFHGVAILSPLLNIEKRKEMQQEKQKALDVEARKQVNRKKALLTRVQEILDNVQVRKAPNASDFDQWEMETVYSNSEVRNLNVPATFPNSFPSHTEHSTAAKLDKIAGILPLDNEDQCKTDGIDLARDSEGFNSPKQCDSSNISHVENEAFPKTSSATPQETLISDGPFSVNEQQDLPLLAEVIPDPYVMSLQNLMKKSKEYIEREQSRRSLRGSINRIVNESHLDKEHDAVEVADCVKEKGQLTGKHCVSVIPDKPSLNKSNVLLQGASTQASSMSMPVLASFSKVDIPIRTGHPTVLESNSDFKVIPTFVTENNVIKSLTGSYAKLPSPEPSMSPKMHRRRSRTSSACHILINNPINACELSPKGKEQAMDLIIQDTDENTNVPEIMPKLPTDLAGVCSSKVYVGKNTSEVKEDVVLGKSNQVCQSSGNHLENKVTHGLVTVEGQLTSDERGAHIMNSTCAAMPKLHEPYASSQCIASPNFGTVSGLKPASMLEKNCSLQTELNKSYDVKNPSPLLMQNQNTRQQMDTPMVSCGNEQFLDNSFEKVKRRLDLDIDGLQKENCPYVITSGITEQERQHLPEKRYPKGSGFVNKNKMLGTSSKESEELLKSKMLAFEEMRKRLEEQHAQQLSLLIAEQEREQERLQKEIEEQEKMLKEKKAMTAEASELDINNAVELEWRKISDSSLLETMLSQADSLHTSNSNSSGFTNSAMQYSFVSANEAPFYLWGSSTSGLTKLSVTRPFGRAKTRWSQVFSLEIQAKFNKITAVAKGFLTRRLMQTDKLKQLRQTVKDTMEFIRSFQSEAPLKRGIVSAQDASLQERVLAQLRAALYGIHDIFFVMDAAERMSILHHDREVRKEKMLRQMDKMKSPRVALSAATQKSLDRKKYMKAAEMGMPNKKFLVKQNPSETRVLQPNQGQNAPVHRLLSRQGTPKTSVKGVVQNRQKPSQSRVPNRVPVSGVYAGKIQRKRPNVATI
uniprot
proteins
function
FUNCTION: Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17681131, PubMed:17719545, PubMed:23486064, PubMed:30375385, PubMed:35301795). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425). {ECO:0000250|UniProtKB:Q7TSH4, ECO:0000269|PubMed:12361598, ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:23486064, ECO:0000269|PubMed:30375385, ECO:0000269|PubMed:35301795}.
uniprot
proteins
mass_dalton
113424
uniprot
proteins
mutagenesis
MUTAGEN 170; /note="S->A: Loss of centrosome clustering and protection from anaphase catastrophe upon CDK2 inhibition in lung cancer cells."; /evidence="ECO:0000269|PubMed:26304236"; MUTAGEN 194; /note="T->A: Loss of centrosome clustering and protection from anaphase catastrophe upon CDK2 inhibition in lung cancer cells."; /evidence="ECO:0000269|PubMed:26304236"; MUTAGEN 586..588; /note="RRL->ARA: Abolishes interaction with CCNF."; /evidence="ECO:0000269|PubMed:20596027
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CDKs. {ECO:0000269|PubMed:12361598}.; PTM: Ubiquitinated by the SCF(CCNF) during G2 phase, leading to its degradation by the proteasome and preventing centrosome reduplication (PubMed:20596027). Deubiquitinated by USP33 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate (PubMed:23486064). Ubiquitinated by the EDVP complex, leading to its degradation (PubMed:28242748, PubMed:34259627). {ECO:0000269|PubMed:20596027, ECO:0000269|PubMed:23486064, ECO:0000269|PubMed:28242748, ECO:0000269|PubMed:34259627}.
uniprot
proteins
pubmed
10493829
uniprot
proteins
pubmed
12361598
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
16760425
uniprot
proteins
pubmed
17681131
uniprot
proteins
pubmed
17719545
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18694559
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19460342
uniprot
proteins
pubmed
20596027
uniprot
proteins
pubmed
21620453
uniprot
proteins
pubmed
22261722
uniprot
proteins
pubmed
22441691
uniprot
proteins
pubmed
22885064
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23486064
uniprot
proteins
pubmed
24421332
uniprot
proteins
pubmed
26304236
uniprot
proteins
pubmed
28242748
uniprot
proteins
pubmed
30375385
uniprot
proteins
pubmed
34259627
uniprot
proteins
pubmed
35301795
uniprot
proteins
pubmed
9455477
uniprot
proteins
sequence_length
1012
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:12361598, ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:16760425, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:17719545, ECO:0000269|PubMed:20596027, ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:30375385}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:30375385}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q7TSH4}. Note=Recruited early and then associates with the growing distal tips. Recruited to the mother centriole by KIF24 (PubMed:21620453). Removed from centrioles by TTBK2, leading to initiation of ciliogenesis and localizes only to the daughter centriole in ciliated cells. In cytotoxic T lymphocytes remains associated with the mother centriole during docking of the centrosome at the immunological synapse upon target contact (By similarity). Recruited at the distal end of the mother centriole by MPHOSPH9 (PubMed:30375385). {ECO:0000250|UniProtKB:Q7TSH4, ECO:0000269|PubMed:21620453, ECO:0000269|PubMed:30375385}.
uniprot
proteins