GRPEL1
entrez
80273
canonical
uniprot
Q9HAV7
canonical
ensembl
ENSG00000109519
resolver
ensp
ENSP00000264954
resolver
enst
ENST00000264954
resolver
genesymbol
GRPEL1
resolver
genesymbol_syn
GREPEL1
resolver
hgnc
HGNC:19696
resolver
uniprot
B2R783
resolver
uniprot
Q549M6
resolver
uniprot_entry
GRPE1_HUMAN
resolver
uniprot_sec
B2R783
resolver
uniprot_sec
Q549M6
resolver
amino_acid_sequence
MAAQCVRLARRSLPALALSLRPSPRLLCTATKQKNSGQNLEEDMGQSEQKADPPATEKTLLEEKVKLEEQLKETVEKYKRALADTENLRQRSQKLVEEAKLYGIQAFCKDLLEVADVLEKATQCVPKEEIKDDNPHLKNLYEGLVMTEVQIQKVFTKHGLLKLNPVGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGVVKEA
uniprot
proteins
function
FUNCTION: Nucleotide exchange factor (NEF) for mitochondrial HSP70 (mt-HSP70/HSPA9), facilitating the release of ADP from HSPA9 to allow ATP rebinding, which is essential for the chaperone cycle (PubMed:28848044). Functions as a component of the presequence translocase-associated motor (PAM) complex, which drives ATP-dependent import of proteins into the mitochondrial matrix. In the PAM complex, supports the HSPA9-driven pulling mechanism that translocates polypeptides through the TIM23 complex (PubMed:28848044). May control the nucleotide-dependent binding of HSPA9 to substrate proteins (PubMed:11311562). {ECO:0000269|PubMed:11311562, ECO:0000269|PubMed:28848044}.
uniprot
proteins
mass_dalton
24279
uniprot
proteins
mutagenesis
MUTAGEN 173; /note="Y->A: Altered HSPA9 interaction and HSPA9 domain positioning."; /evidence="ECO:0000269|PubMed:39737924
uniprot
proteins
protein_family
GrpE family
uniprot
proteins
pubmed
11311562
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28848044
uniprot
proteins
pubmed
30098457
uniprot
proteins
pubmed
39737924
uniprot
proteins
sequence_length
217
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:11311562, ECO:0000269|PubMed:30098457}.
uniprot
proteins