RBBP4
entrez
5928
canonical
uniprot
Q09028
canonical
ensembl
ENSG00000162521
resolver
ensp
ENSP00000362592
resolver
ensp
ENSP00000396057
resolver
ensp
ENSP00000398242
resolver
genesymbol
RBBP4
resolver
genesymbol_syn
RBAP48
resolver
hgnc
HGNC:9887
resolver
uniprot
B2R6G9
resolver
uniprot
B4DRH0
resolver
uniprot
D3DPQ3
resolver
uniprot
P31149
resolver
uniprot
Q53H02
resolver
uniprot
Q96BV9
resolver
uniprot_entry
RBBP4_HUMAN
resolver
uniprot_sec
B2R6G9
resolver
uniprot_sec
B4DRH0
resolver
uniprot_sec
D3DPQ3
resolver
uniprot_sec
P31149
resolver
uniprot_sec
Q53H02
resolver
uniprot_sec
Q96BV9
resolver
amino_acid_sequence
MADKEAAFDDAVEERVINEEYKIWKKNTPFLYDLVMTHALEWPSLTAQWLPDVTRPEGKDFSIHRLVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEKGEFGGFGSVSGKIEIEIKINHEGEVNRARYMPQNPCIIATKTPSSDVLVFDYTKHPSKPDPSGECNPDLRLRGHQKEGYGLSWNPNLSGHLLSASDDHTICLWDISAVPKEGKVVDAKTIFTGHTAVVEDVSWHLLHESLFGSVADDQKLMIWDTRSNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHSFESHKDEIFQVQWSPHNETILASSGTDRRLNVWDLSKIGEEQSPEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQVWQMAENIYNDEDPEGSVDPEGQGS
uniprot
proteins
function
FUNCTION: Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA (PubMed:10866654). Component of the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair (PubMed:8858152). Component of the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression (PubMed:9150135). Component of the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling (PubMed:16428440, PubMed:28977666, PubMed:39460621). Component of the PRC2 complex, which promotes repression of homeotic genes during development (PubMed:29499137, PubMed:31959557). Component of the NURF (nucleosome remodeling factor) complex (PubMed:14609955, PubMed:15310751). {ECO:0000269|PubMed:10866654, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:15310751, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557, ECO:0000269|PubMed:39460621, ECO:0000269|PubMed:8858152, ECO:0000269|PubMed:9150135}.
uniprot
proteins
mass_dalton
47656
uniprot
proteins
mutagenesis
MUTAGEN 35; /note="V->A: Loss of interaction with ARMC12."; /evidence="ECO:0000269|PubMed:30026490"; MUTAGEN 43; /note="P->A: Loss of interaction with ZNF827 and loss of localization to telomeres; when associated with A-73."; /evidence="ECO:0000269|PubMed:30045876"; MUTAGEN 73; /note="S->A: Loss of interaction with ZNF827 and loss of localization to telomeres; when associated with A-43."; /evidence="ECO:0000269|PubMed:30045876"; MUTAGEN 126..128; /note="EVN->AVA: Loss of interaction with ZNF827."; /evidence="ECO:0000305|PubMed:30045876"; MUTAGEN 126; /note="E->A: Loss of interaction with ZNF827 and loss of localization to telomeres; when associated with A-128 and A-179."; /evidence="ECO:0000269|PubMed:30045876"; MUTAGEN 128; /note="N->A: Loss of interaction with ZNF827 and loss of localization to telomeres; when associated with A-126 and A-179."; /evidence="ECO:0000269|PubMed:30045876"; MUTAGEN 179; /note="E->A: Loss of interaction with ZNF827 and loss of localization to telomeres; when associated with A-126 and A-128."; /evidence="ECO:0000269|PubMed:30045876"; MUTAGEN 181; /note="Y->A: Loss of interaction with ZNF827 and loss of localization to telomeres."; /evidence="ECO:0000269|PubMed:30045876"; MUTAGEN 231; /note="E->A: Decreased interaction with ZNF827; when associated with A-277."; /evidence="ECO:0000305|PubMed:30045876"; MUTAGEN 277; /note="N->A: Decreased interaction with ZNF827; when associated with A-231."; /evidence="ECO:0000305|PubMed:30045876"; MUTAGEN 395; /note="E->A: Decreased interaction with ZNF827."; /evidence="ECO:0000305|PubMed:30045876
uniprot
proteins
protein_family
WD repeat RBAP46/RBAP48/MSI1 family
uniprot
proteins
pubmed
10220405
uniprot
proteins
pubmed
10444591
uniprot
proteins
pubmed
10734134
uniprot
proteins
pubmed
10866654
uniprot
proteins
pubmed
11102443
uniprot
proteins
pubmed
11118440
uniprot
proteins
pubmed
11331609
uniprot
proteins
pubmed
11784859
uniprot
proteins
pubmed
12198550
uniprot
proteins
pubmed
12351676
uniprot
proteins
pubmed
12435631
uniprot
proteins
pubmed
1286667
uniprot
proteins
pubmed
12920132
uniprot
proteins
pubmed
14609955
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15310751
uniprot
proteins
pubmed
15456747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15701600
uniprot
proteins
pubmed
16428440
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
1699755
uniprot
proteins
pubmed
17531812
uniprot
proteins
pubmed
17671431
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20523938
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24554700
uniprot
proteins
pubmed
24920672
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
26030138
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28977666
uniprot
proteins
pubmed
29499137
uniprot
proteins
pubmed
30026490
uniprot
proteins
pubmed
30045876
uniprot
proteins
pubmed
30462309
uniprot
proteins
pubmed
31959557
uniprot
proteins
pubmed
33283408
uniprot
proteins
pubmed
39460621
uniprot
proteins
pubmed
7503932
uniprot
proteins
pubmed
8350924
uniprot
proteins
pubmed
8602529
uniprot
proteins
pubmed
8858152
uniprot
proteins
pubmed
9150135
uniprot
proteins
pubmed
9427644
uniprot
proteins
pubmed
9520398
uniprot
proteins
pubmed
9651585
uniprot
proteins
pubmed
9790534
uniprot
proteins
sequence_length
425
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10220405, ECO:0000269|PubMed:10866654, ECO:0000269|PubMed:14609955, ECO:0000269|PubMed:20523938, ECO:0000269|PubMed:28977666, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:30026490, ECO:0000269|PubMed:33283408, ECO:0000269|PubMed:39460621, ECO:0000269|PubMed:8858152}. Chromosome, telomere {ECO:0000269|PubMed:30045876}. Note=Localizes to chromatin as part of the PRC2 complex. {ECO:0000269|PubMed:29499137}.
uniprot
proteins