P11260
uniprot
P11260
canonical
amino_acid_sequence
MAKGKRKNPTNRNQDHSPSSERSTPTPPSPGHPNTTENLDPDLKTFLMMMIEDIKKDFHKSLKDLQESTAKELQALKEKQENTAKQVMEMNKTILELKGEVDTIKKTQSEATLEIETLGKRSGTIDASISNRIQEMEERISGAEDSIENIDTTVKENTKCKRILTQNIQVIQDTMRRPNLRIIGIDENEDFQLKGPANIFNKIIEENFPNIKKEMPMIIQEAYRTPNRLDQKRNSSRHIIIRTTNALNKDRILKAVREKGQVTYKGRPIRITPDFSPETMKARRAWTDVIQTLREHKCQPRLLYPAKLSITIDGETKVFHDKTKFTQYLSTNPALQRIITEKKQYKDGNHALEQPRK
uniprot
proteins
function
FUNCTION: Nucleic acid-binding protein which is essential for retrotransposition of LINE-1 elements in the genome. Functions as a nucleic acid chaperone binding its own transcript and therefore preferentially mobilizing the transcript from which they are encoded. {ECO:0000269|PubMed:11134335, ECO:0000269|PubMed:28806172}.
uniprot
proteins
mass_dalton
41226
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated, probably by UBR2, which induces its degradation. {ECO:0000269|PubMed:28806172}.
uniprot
proteins
protein_family
Transposase 22 family
uniprot
proteins
pubmed
11134335
uniprot
proteins
pubmed
11591644
uniprot
proteins
pubmed
14615577
uniprot
proteins
pubmed
17569664
uniprot
proteins
pubmed
28662698
uniprot
proteins
pubmed
28806172
uniprot
proteins
pubmed
3023821
uniprot
proteins
sequence_length
357
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9UN81}. Cytoplasm {ECO:0000269|PubMed:28806172}. Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000250|UniProtKB:Q9UN81}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:Q9UN81}. Note=Colocalizes with its encoding RNA in cytoplasmic ribonucleoprotein particle. Mainly cytoplasmic, rarely detected in the nucleus, possibly within the nucleolus. {ECO:0000250|UniProtKB:Q9UN81}.
uniprot
proteins