Msx1
entrez
17701
canonical
uniprot
P13297
canonical
ensembl
ENSMUSG00000048450
resolver
ensp
ENSMUSP00000058354
resolver
enst
ENSMUST00000063116
resolver
genesymbol
Msx1
resolver
genesymbol_syn
Hox7
resolver
genesymbol_syn
Hox7.1
resolver
uniprot
Q91W75
resolver
uniprot
Q9ERF6
resolver
uniprot_entry
MSX1_MOUSE
resolver
uniprot_sec
Q91W75
resolver
uniprot_sec
Q9ERF6
resolver
amino_acid_sequence
MAPAAAMTSLPLGVKVEDSAFAKPAGGGVGQAPGAAAATATAMGTDEEGAKPKVPASLLPFSVEALMADHRKPGAKESVLVASEGAQAAGGSVQHLGTRPGSLGAPDAPSSPRPLGHFSVGGLLKLPEDALVKAESPEKLDRTPWMQSPRFSPPPARRLSPPACTLRKHKTNRKPRTPFTTAQLLALERKFRQKQYLSIAERAEFSSSLSLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPPAAFGLSFPLGGPAAVAAAAGASLYSASGPFQRAALPVAPVGLYTAHVGYSMYHLT
uniprot
proteins
function
FUNCTION: Acts as a transcriptional repressor (PubMed:23371388, PubMed:7823952). Capable of transcription autoinactivation (PubMed:10215616). Binds to the consensus sequence 5'-C/GTAAT-3' in downstream activin regulatory elements (DARE) in the gene promoter, thereby repressing the transcription of CGA/alpha-GSU and GNRHR (PubMed:23371388). Represses transcription of myoblast differentiation factors (PubMed:16600910). Binds to core enhancer regions in target gene promoters of myoblast differentiation factors with binding specificity facilitated by interaction with PIAS1 (PubMed:16600910). Regulates, in a stage-specific manner, a developmental program of gene expression in the fetal tooth bud that controls odontoblast differentiation and proliferation of dental mesenchymal cells (PubMed:24028588, PubMed:27713059, PubMed:29148101, PubMed:7914451, PubMed:8898217). At the bud stage, required for mesenchymal molar tooth bud development via facilitating reciprocal signaling between dental epithelial and mesenchymal cells (PubMed:8898217). May also regulate expression of Wnt antagonists such as DKK2 and SFPR2 in the developing tooth mesenchyme (PubMed:27713059). Required for BMP4 expression in dental mesenchyme cells (PubMed:8898217). Also, in response to BMP4, required for BMP4 expression in neighboring dental epithelial cells (PubMed:8898217). Required for maximal FGF4-induced expression of SDC1 in dental mesenchyme cells (PubMed:8898217). Also in response to SDC1, required for SDC1 expression in neighboring dental epithelial cells (PubMed:8898217). At the early bell stage, acts to drive proliferation of dental mesenchyme cells, however during the late bell stage acts as a homeostatic regulator of the cell cycle (PubMed:24028588, PubMed:29148101). Regulates proliferation and inhibits premature mesenchymal odontogenesis during the bell stage via inhibition of the Wnt signaling component CTNNB1 and subsequent repression of the odontoblast differentiation factors BMP2, BMP4, LEF1, ALPL and BGLAP/OCN (PubMed:24028588, PubMed:29148101). Additionally, required for correct development and fusion of the palatal shelves and embryonic mandibular formation (PubMed:7914451). Plays a role in embryonic bone formation of the middle ear, skull and nasal bones (PubMed:7914451). Required for correct formation and thickness of the nail plate (PubMed:11369996). May play a role in limb-pattern formation (PubMed:1677742). {ECO:0000250|UniProtKB:P28360, ECO:0000269|PubMed:10215616, ECO:0000269|PubMed:11369996, ECO:0000269|PubMed:16600910, ECO:0000269|PubMed:1677742, ECO:0000269|PubMed:23371388, ECO:0000269|PubMed:24028588, ECO:0000269|PubMed:27713059, ECO:0000269|PubMed:29148101, ECO:0000269|PubMed:7823952, ECO:0000269|PubMed:7914451, ECO:0000269|PubMed:8898217}.
uniprot
proteins
mass_dalton
31672
uniprot
proteins
mutagenesis
MUTAGEN 15; /note="K->R: Abolishes sumoylation. No effect on interaction with PIAS1."; /evidence="ECO:0000269|PubMed:16600910, ECO:0000269|PubMed:16678795"; MUTAGEN 53; /note="K->R: Sumoylated."; /evidence="ECO:0000269|PubMed:16678795"; MUTAGEN 72; /note="K->R: Sumoylated."; /evidence="ECO:0000269|PubMed:16678795"; MUTAGEN 125; /note="K->R: Sumoylated."; /evidence="ECO:0000269|PubMed:16678795"; MUTAGEN 133; /note="K->R: Abolishes sumoylation. No effect on interaction with PIAS1."; /evidence="ECO:0000269|PubMed:16600910, ECO:0000269|PubMed:16678795"; MUTAGEN 139; /note="K->R: Sumoylated."; /evidence="ECO:0000269|PubMed:16678795"; MUTAGEN 299..303; /note="Missing: Abolishes interaction with PIAS1."; /evidence="ECO:0000269|PubMed:16600910
uniprot
proteins
post_translational_modification
PTM: Sumoylated by PIAS1, desumoylated by SENP1 (PubMed:16678795). Sumoylation of Lys-15 and Lys-133 not required for interaction with H1-5, transcriptional repression, inhibition of myoblast differentiation, or binding to gene promoters (PubMed:16600910). {ECO:0000269|PubMed:16600910, ECO:0000269|PubMed:16678795}.
uniprot
proteins
protein_family
Msh homeobox family
uniprot
proteins
pubmed
10215616
uniprot
proteins
pubmed
11369996
uniprot
proteins
pubmed
11580277
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16600910
uniprot
proteins
pubmed
16678795
uniprot
proteins
pubmed
1673109
uniprot
proteins
pubmed
1677742
uniprot
proteins
pubmed
1682128
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22629437
uniprot
proteins
pubmed
23371388
uniprot
proteins
pubmed
24028588
uniprot
proteins
pubmed
2565278
uniprot
proteins
pubmed
2565810
uniprot
proteins
pubmed
27713059
uniprot
proteins
pubmed
29148101
uniprot
proteins
pubmed
37405986
uniprot
proteins
pubmed
7823952
uniprot
proteins
pubmed
7914451
uniprot
proteins
pubmed
8898217
uniprot
proteins
sequence_length
303
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16600910, ECO:0000269|PubMed:23371388}. Note=Interaction with PIAS1 is required for localization to the nuclear periphery (PubMed:16600910). {ECO:0000269|PubMed:16600910}.
uniprot
proteins