SULT1B1
entrez
27284
canonical
uniprot
O43704
canonical
ensembl
ENSG00000173597
resolver
ensp
ENSP00000308770
resolver
ensp
ENSP00000538595
resolver
ensp
ENSP00000538597
resolver
enst
ENST00000310613
resolver
enst
ENST00000868536
resolver
enst
ENST00000868538
resolver
genesymbol
SULT1B1
resolver
genesymbol_syn
ST1B2
resolver
genesymbol_syn
SULT1B2
resolver
hgnc
HGNC:17845
resolver
uniprot
O15497
resolver
uniprot
Q96FI1
resolver
uniprot
Q9UK34
resolver
uniprot_entry
ST1B1_HUMAN
resolver
uniprot_sec
O15497
resolver
uniprot_sec
Q96FI1
resolver
uniprot_sec
Q9UK34
resolver
amino_acid_sequence
MLSPKDILRKDLKLVHGYPMTCAFASNWEKIEQFHSRPDDIVIATYPKSGTTWVSEIIDMILNDGDIEKCKRGFITEKVPMLEMTLPGLRTSGIEQLEKNPSPRIVKTHLPTDLLPKSFWENNCKMIYLARNAKDVSVSYYHFDLMNNLQPFPGTWEEYLEKFLTGKVAYGSWFTHVKNWWKKKEEHPILFLYYEDMKENPKEEIKKIIRFLEKNLNDEILDRIIHHTSFEVMKDNPLVNYTHLPTTVMDHSKSPFMRKGTAGDWKNYFTVAQNEKFDAIYETEMSKTALQFRTEI
uniprot
proteins
ec_number
2.8.2.1
uniprot
proteins
function
FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3) (PubMed:28084139, PubMed:9443824, PubMed:9463486). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system (PubMed:35165440). {ECO:0000269|PubMed:28084139, ECO:0000269|PubMed:35165440, ECO:0000269|PubMed:9443824, ECO:0000269|PubMed:9463486}.
uniprot
proteins
mass_dalton
34899
uniprot
proteins
protein_family
Sulfotransferase 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16804942
uniprot
proteins
pubmed
28084139
uniprot
proteins
pubmed
35165440
uniprot
proteins
pubmed
9443824
uniprot
proteins
pubmed
9463486
uniprot
proteins
sequence_length
296
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9443824, ECO:0000269|PubMed:9463486}.
uniprot
proteins