Dgat1
entrez
84497
canonical
uniprot
Q9ERM3
canonical
ensembl
ENSRNOG00000028711
resolver
ensp
ENSRNOP00000035110
resolver
genesymbol
Dgat1
resolver
genesymbol_syn
DGAT
resolver
genesymbol_syn
Dgat
resolver
uniprot
A6HSA3
resolver
uniprot
Q8BHI5
resolver
uniprot_entry
DGAT1_RAT
resolver
uniprot_entry
Q8BHI5_RAT
resolver
uniprot_sec
A6HSA3
resolver
amino_acid_sequence
MGDRGGAGSSRRRRTGSRVSVQGGSGPKVEEDEVREAAVSPDLGAGGDAPAPAPAPAHTRDKDRQTSVGDGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLSLENLIKYGILVDPIQVVSLFLKDPYSWPAPCLIIASNIFIVATFQIEKRLSVGALTEQMGLLLHVVNLATIICFPAAVALLVESITPVGSLFALASYSIIFLKLSSYRDVNLWCRQRRVKAKAVSAGKKVSGAAAQNTVSYPDNLTYRDLYYFIFAPTLCYELNFPRSPRIRKRFLLRRVLEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELLQFGDREFYRDWWNAESVTYFWQNWNIPVHKWCIRHFYKPMLRLGSNKWMARTGVFWASAFFHEYLVSIPLRMFRLWAFTAMMAQVPLAWIVNRFFQGNYGNAAVWVTLIIGQPVAVLMYVHDYYVLNYDAPVGA
uniprot
proteins
ec_number
2.3.1.20
uniprot
proteins
ec_number
2.3.1.76
uniprot
proteins
function
FUNCTION: Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Highly expressed in epithelial cells of the small intestine and its activity is essential for the absorption of dietary fats. In liver, plays a role in esterifying exogenous fatty acids to glycerol, and is required to synthesize fat for storage (By similarity). Also present in female mammary glands, where it produces fat in the milk (By similarity). May be involved in VLDL (very low density lipoprotein) assembly (By similarity). In contrast to DGAT2 it is not essential for survival (By similarity). Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders (By similarity). Exhibits additional acyltransferase activities, includin acyl CoA:monoacylglycerol acyltransferase (MGAT), wax monoester and wax diester synthases (By similarity). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (By similarity). {ECO:0000250|UniProtKB:O75907, ECO:0000250|UniProtKB:Q8MK44, ECO:0000250|UniProtKB:Q9Z2A7}.
uniprot
proteins
mass_dalton
56870
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; glycerolipid metabolism.
uniprot
proteins
protein_family
Membrane-bound acyltransferase family
uniprot
proteins
protein_family
Sterol o-acyltransferase subfamily
uniprot
proteins
sequence_length
498
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Z2A7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9Z2A7}.
uniprot
proteins
transmembrane_region
TRANSMEM 93..127; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:O75907"; TRANSMEM 140..165; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:O75907"; TRANSMEM 171..193; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:O75907"; TRANSMEM 201..232; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:O75907"; TRANSMEM 285..319; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:O75907"; TRANSMEM 327..364; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:O75907"; TRANSMEM 411..431; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:O75907"; TRANSMEM 440..458; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:O75907"; TRANSMEM 461..492; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:O75907
uniprot
proteins