Srgn
entrez
19073
canonical
uniprot
P13609
canonical
ensembl
ENSMUSG00000020077
resolver
ensp
ENSMUSP00000020271
resolver
ensp
ENSMUSP00000125533
resolver
ensp
ENSMUSP00000125622
resolver
enst
ENSMUST00000020271
resolver
enst
ENSMUST00000160987
resolver
enst
ENSMUST00000162161
resolver
genesymbol
Srgn
resolver
genesymbol_syn
Prg
resolver
genesymbol_syn
Prg1
resolver
uniprot
Q3TZD4
resolver
uniprot
Q8C2U2
resolver
uniprot_entry
SRGN_MOUSE
resolver
uniprot_sec
Q3TZD4
resolver
uniprot_sec
Q8C2U2
resolver
amino_acid_sequence
MQVPVGSRLVLALAFVLVWGSSVQGYPARRARYQWVRCKPNGFFANCIEEKGPQFDLIDESNNIGPPMNNPVLMEGPSKDFISNYDDYGSGSGSGSGSGSGSGSGSGSGFLGDMEWEYQPTDESNIVYFNYKPFDRILTEQNQDQPEDDFII
uniprot
proteins
function
FUNCTION: Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF and may also regulate protease secretion. Inhibits bone mineralization. {ECO:0000269|PubMed:15231821, ECO:0000269|PubMed:16046402, ECO:0000269|PubMed:16807245, ECO:0000269|PubMed:17010166, ECO:0000269|PubMed:17081126, ECO:0000269|PubMed:17147513, ECO:0000269|PubMed:17272511}.
uniprot
proteins
mass_dalton
16711
uniprot
proteins
post_translational_modification
PTM: O-glycosylated; contains chondroitin sulfate and heparan sulfate. {ECO:0000269|PubMed:17010166, ECO:0000269|PubMed:7535771}.
uniprot
proteins
protein_family
Serglycin family
uniprot
proteins
pubmed
15231821
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16046402
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16807245
uniprot
proteins
pubmed
17010166
uniprot
proteins
pubmed
17081126
uniprot
proteins
pubmed
17147513
uniprot
proteins
pubmed
17272511
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2121613
uniprot
proteins
pubmed
2532501
uniprot
proteins
pubmed
2726751
uniprot
proteins
pubmed
2777804
uniprot
proteins
pubmed
7535771
uniprot
proteins
pubmed
8502243
uniprot
proteins
sequence_length
152
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic granule {ECO:0000269|PubMed:16046402}. Cytolytic granule {ECO:0000250|UniProtKB:P10124}. Secreted, extracellular space {ECO:0000269|PubMed:16046402}. Golgi apparatus {ECO:0000250|UniProtKB:P10124}. Note=Found in mast cell granules and in cytoplasmic granules of cytolytic T-lymphocytes from where it is secreted upon cell activation (PubMed:16046402). Secreted constitutively by endothelial cells and macrophages. Located to Golgi apparatus during neutrophil differentiation (By similarity). {ECO:0000250|UniProtKB:P10124, ECO:0000269|PubMed:16046402}.
uniprot
proteins