Trim17
entrez
56631
canonical
uniprot
Q7TPM3
canonical
ensembl
ENSMUSG00000036964
resolver
ensp
ENSMUSP00000074639
resolver
ensp
ENSMUSP00000322477
resolver
ensp
ENSMUSP00000322481
resolver
enst
ENSMUST00000075141
resolver
genesymbol
Trim17
resolver
uniprot
A2AB82
resolver
uniprot
Q99PP8
resolver
uniprot_entry
TRI17_MOUSE
resolver
uniprot_sec
A2AB82
resolver
uniprot_sec
Q99PP8
resolver
amino_acid_sequence
MDAVELARRLQEEATCSICLDYFTDPVMTACGHNFCRECIQMSWEKGKVKKGKKKQKGSFPCPECREMSPQRNLRPNRLLTKVAEMARQHPGLQKRDLCQAHQEPLKLFCQDDQSPICVVCREAQEHRMHRVLPLDEAAREYKLKLEEDIKYLREEMMKTETLQAKEEQTLTEWQERVKERRERILEEFQKVVLFLVEEERRILQVLKKEEEDTLGKLQDSKASLDHQSRSLDLILLQLEERSQQEPLQMLQDVKDTLNRKESFSVQYPEVVLPAAIKTLCRVPGQIEVLKSFQEDVMPDPSSAYPYLLLYESRQRRYLSPPPEGSAPYSKDRFVAYPCAVGQKSFSSGRHYWEVGMNLTGDALWALGVCRDNVSRKDRVLKSPENGFWVVQLSKGKKQLSLLPNSTLVTLTEPPSHMGIFLDFQAGEVSFYSVNDGSHLHSFSQAAFPGPLLPFFCLGAPKSGQMVISTVTMWVKG
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase that plays important roles in the regulation of neuronal apoptosis, selective autophagy or cell proliferation (PubMed:20559321, PubMed:22976837, PubMed:25215946). Stimulates the degradation of kinetochore ZW10 interacting protein ZWINT in a proteasome-dependent manner, leading to negative regulation of cell proliferation. Inhibits autophagic degradation of diverse known targets while contributing to autophagy of midbodies. Autophagy-inhibitory activity involves MCL1, which TRIM17 assembles into complexes with the key autophagy regulator BECN1 (By similarity). Controls neuronal apoptosis by mediating ubiquitination and degradation of MCL1 to initiate neuronal death (PubMed:22976837). In addition, regulates NFAT transcription factors NFATC3 and NFATC4 activities by preventing their nuclear localization, thus inhibiting their transcriptional activities (PubMed:25215946). Decreases TRIM41-mediated degradation of ZSCAN2 thereby stimulating alpha-synuclein/SNCA transcription in neuronal cells (PubMed:30485814). Prevents the E3 ubiquitin-ligase activity of TRIM28 and its interaction with anti-apoptotic BCL2A1, blocking TRIM28 from ubiquitinating BCL2A1 (By similarity). {ECO:0000250|UniProtKB:Q9Y577, ECO:0000269|PubMed:20559321, ECO:0000269|PubMed:22976837, ECO:0000269|PubMed:25215946, ECO:0000269|PubMed:30485814}.
uniprot
proteins
mass_dalton
54863
uniprot
proteins
mutagenesis
MUTAGEN 16; /note="C->A: Complete loss of auto-ubiquitination."; /evidence="ECO:0000269|PubMed:20559321
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated. {ECO:0000269|PubMed:20559321}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
11331580
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20559321
uniprot
proteins
pubmed
22976837
uniprot
proteins
pubmed
25215946
uniprot
proteins
pubmed
30485814
uniprot
proteins
sequence_length
477
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Y577}. Lysosome {ECO:0000250|UniProtKB:Q9Y577}.
uniprot
proteins