Mastl
entrez
67121
canonical
uniprot
Q8C0P0
canonical
ensembl
ENSMUSG00000026779
resolver
ensp
ENSMUSP00000028119
resolver
genesymbol
Mastl
resolver
genesymbol_syn
Gw
resolver
genesymbol_syn
Gwl
resolver
uniprot
A2AQY2
resolver
uniprot
Q3MIA9
resolver
uniprot
Q5RJW0
resolver
uniprot
Q6NXX9
resolver
uniprot
Q8BVF3
resolver
uniprot
Q9CZH9
resolver
uniprot
Q9D9V0
resolver
uniprot_entry
GWL_MOUSE
resolver
uniprot_sec
A2AQY2
resolver
uniprot_sec
Q3MIA9
resolver
uniprot_sec
Q5RJW0
resolver
uniprot_sec
Q6NXX9
resolver
uniprot_sec
Q8BVF3
resolver
uniprot_sec
Q9CZH9
resolver
uniprot_sec
Q9D9V0
resolver
amino_acid_sequence
MESASASEENEGGAAIEECVSRIPVPRPPSIEEFTIVKPISRGAFGKVYLGQKGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFVVHLYYSLQSASNIYLIMEYLIGGDVKSLLHIYGYFDEEMAIKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTPSMSKPKQDYSRTPGQVLSLISSLGFFTPVGEKDQDSANMFSAPKSAAQLSRGFICPMSVDQKEPTSYSSKLLKSCFETLSSNPEIPVKCLTSNLLQCRKRLGTSSTSSQSHTFVSSVESECHSNPKWERDCQSTESSGCAMSWNAVEMLYAKSTSAIKTKTELELALSPIHDSSAIPAAGSNQVTLPRKCFREISWEARDPDNENMTIDKGQSGFCQSSQRSVNSSATSEEHLGKRNYKRNFHLVDSSPCQEIMQSKKNCTEYEANKERQGCRANQSTGLTTEVQNLKLSGCESQQLDYANKENIVTYLTDRQTPEKLHIPTIAKNLMSELDEDCELSSKKDCLSSNSVCSDEDRALKTTCVDSDSSFPGVSMMESSLEIQALEPDKSIRDYSFEEPNTEDLFVLPKCQENSLPQDDCHACIQDSSQVSAHPSKAPKALTSKINVVAFRSFNSHINASTNSEPSKISITSLDAMDISCDYSGSYPMAVSPTEKGRHYTSHQTPNQVKLGTSYRTPKSVRRGAAPVDDGRILGTPDYLAPELLLGTAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLSDNAQSAMDMLLTIDDSKRAGMRELKQHPLFSEVDWENLQHQTMPFVPQPDDETDTSYFEARNNAQHLTISGFSL
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:21156286). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (By similarity). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (By similarity). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. {ECO:0000250|UniProtKB:Q96GX5, ECO:0000269|PubMed:21156286}.
uniprot
proteins
mass_dalton
95975
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-727 by CDK1 during M phase activates its kinase activity. Maximum phosphorylation occurs in prometaphase (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21156286
uniprot
proteins
sequence_length
865
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Nucleus. Note=During interphase is mainly nuclear, upon nuclear envelope breakdown localizes at the cytoplasm and during mitosis at the centrosomes. {ECO:0000250}.
uniprot
proteins