Siah1b
entrez
20438
canonical
uniprot
Q06985
canonical
ensembl
ENSMUSG00000040749
resolver
ensp
ENSMUSP00000043215
resolver
ensp
ENSMUSP00000071592
resolver
ensp
ENSMUSP00000173117
resolver
enst
ENSMUST00000037928
resolver
enst
ENSMUST00000071667
resolver
genesymbol
Siah1b
resolver
uniprot
A2AHZ2
resolver
uniprot
Q7TPV6
resolver
uniprot_entry
A2AHZ2_MOUSE
resolver
uniprot_entry
SIA1B_MOUSE
resolver
uniprot_sec
Q7TPV6
resolver
amino_acid_sequence
MSRQAATALSTGTSKCPPSQRVPALTDTTASNNDLASLFECPVCFDYVLPPILQCQSGHLVCSNCRPKLTCCPTCRGPLGSIRNLAVEKVANSVLFPCKYSASGCEITLPHTKKAEHEELCEFRPYSCPCPGASCKWQGSLDAVMPHLMHQHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGFHFMLVLEKQEKYDGHQQFFAIVQLIGTRKQAENFAYRLELNGHRRRLTWEATPRSIHEGIATAIMNSDCLVFDTSIAQLFAENGNLGINVTISMC
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. {ECO:0000250|UniProtKB:Q8IUQ4, ECO:0000250|UniProtKB:Q920M9}.
uniprot
proteins
mass_dalton
31122
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q8IUQ4}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser-19 by ATM and ATR. {ECO:0000250|UniProtKB:Q8IUQ4}.
uniprot
proteins
protein_family
SINA (Seven in absentia) family
uniprot
proteins
pubmed
12842817
uniprot
proteins
pubmed
14985507
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8404535
uniprot
proteins
pubmed
8632996
uniprot
proteins
sequence_length
282
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. Partially nuclear. {ECO:0000250}.
uniprot
proteins