RAB24
entrez
53917
canonical
uniprot
Q969Q5
canonical
ensembl
ENSG00000169228
resolver
ensp
ENSP00000304376
resolver
ensp
ENSP00000377235
resolver
enst
ENST00000303251
resolver
enst
ENST00000393611
resolver
genesymbol
RAB24
resolver
hgnc
HGNC:9765
resolver
uniprot
A0A024R7N9
resolver
uniprot
Q7Z4Z7
resolver
uniprot_entry
RAB24_HUMAN
resolver
uniprot_sec
A0A024R7N9
resolver
uniprot_sec
Q7Z4Z7
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP (Probable). Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity (Probable). Inhibited by GDP dissociation inhibitors (GDIs) (Probable). {ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MSGQRVDVKVVMLGKEYVGKTSLVERYVHDRFLVGPYQNTIGAAFVAKVMSVGDRTVTLGIWDTAGSERYEAMSRIYYRGAKAAIVCYDLTDSSSFERAKFWVKELRSLEEGCQIYLCGTKSDLLEEDRRRRRVDFHDVQDYADNIKAQLFETSSKTGQSVDELFQKVAEDYVSVAAFQVMTEDKGVDLGQKPNPYFYSCCHH
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB24 is an atypical RAB protein that presents low GTPase activity and thereby exists predominantly in the GTP-bound active state. RAB24 is required for the clearance of late autophagic vacuoles under basal conditions. It is not needed for starvation-induced autophagy. Involved in the modulation of meiotic apparatus assembly and meiotic progression during oocyte maturation, possibly through regulation of kinetochore-microtubule interaction. {ECO:0000250|UniProtKB:P35290}.
uniprot
proteins
mass_dalton
23124
uniprot
proteins
post_translational_modification
PTM: Prenylated; prenylation is required for RAB24 localization to autophagosomes (By similarity). Isoprenylation is inefficient compared to other Rab family members (PubMed:10660536). {ECO:0000250|UniProtKB:P35290, ECO:0000269|PubMed:10660536}.; PTM: Phosphorylated at Tyr-17 and Tyr-172 (By similarity). Cytosolic pool of RAB24 is more phosphorylated than the membrane-associated pool (By similarity). {ECO:0000250|UniProtKB:P35290}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10660536
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16034420
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21269460
uniprot
proteins
sequence_length
203
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10660536}. Membrane {ECO:0000269|PubMed:10660536}; Lipid-anchor {ECO:0000305}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:P35290}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P35290}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:P35290}. Note=Only about 20% is recovered in the particulate fraction (PubMed:10660536). RAB24 localizes in perinuclear region and in the limiting membranes of autophagic compartments under basal conditions. RAB24 is localized in the cytoplasm with an accumulated distribution in nuclear region at germinal vesicle (GV) stage of oocyte meiotic progression. At pre-metaphase I stage, localized in the cytoplasm with a particular concentration around chromosomes. As the oocytes enter metaphase I, located to the spindle region. Similar distribution pattern is observed in MII oocytes (By similarity). {ECO:0000250|UniProtKB:P35290, ECO:0000269|PubMed:10660536}.
uniprot
proteins