Q8BHL4
uniprot
Q8BHL4
canonical
amino_acid_sequence
MTTPTTAPSGCRSDLDSRYHRLCDLAEGWGIALETLAAVGAVATVACMFALVFLICKVQDSNKRKMLPAQFLFLLGVLGVFGLTFAFIIKLDGATGPTRFFLFGVLFAICFSCLLAHAFNLIKLVRGRKPLSWLVILSLAVGFSLVQDVIAIEYLVLTMNRTNVNVFSELPAPRRNEDFVMLLIYVLVLMVLTFFTSFLVFCGSFSGWKRHGFHICFTSFLSIAIWVAWIVLLLIPDIDRKWDDTILSTALVANGWVFLAFYILPEFRQLPRQRSPTDYPVEDAFCKPQLMKQSYGVENRAYSQEEITQGLEMGDTLYAPYSTHFQLQNHQKDFSIPRAQAPASPYNDYEGRKGDS
uniprot
proteins
function
FUNCTION: Orphan receptor. Could be involved in modulating differentiation and maintaining homeostasis of epithelial cells. This retinoic acid-inducible GPCR provides evidence for a possible interaction between retinoid and G protein signaling pathways. Functions as a negative modulator of EGFR signaling (PubMed:25744720). Acts as a lung tumor suppressor (PubMed:18000218). {ECO:0000269|PubMed:18000218, ECO:0000269|PubMed:25744720}.
uniprot
proteins
mass_dalton
40101
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in two conserved double-tyrosine motifs, Tyr 318/Tyr-321 and Tyr-346/Tyr-349 by EGFR. Tyr-318 and Tyr-321 are the preferred residues responsible for EGFR-mediated GPRC5A phosphorylation. {ECO:0000250|UniProtKB:Q8NFJ5}.
uniprot
proteins
protein_family
G protein-coupled receptor 3 family
uniprot
proteins
pubmed
14706456
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
18000218
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25744720
uniprot
proteins
sequence_length
356
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18000218}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..56; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 69..89; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 102..122; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 132..152; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 179..199; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 215..235; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 245..265; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins