Tk1
entrez
24834
canonical
uniprot
P27158
canonical
ensembl
ENSRNOG00000047314
resolver
ensp
ENSRNOP00000067459
resolver
genesymbol
Tk1
resolver
genesymbol_syn
Tk-1
resolver
uniprot
Q6LAG4
resolver
uniprot_entry
KITH_RAT
resolver
uniprot_sec
Q6LAG4
resolver
amino_acid_sequence
MSYINLPTVLPISPSKTRGQIQVILGPMFSGKSTELMRRVRRFQIAQYKCLVIKYAKDTRYSNSFSTHDRNTMDALPACMLKDVAQEALGVAVIGIDEGQFFPDIVDFCETMANTGKTVIV
uniprot
proteins
ec_number
2.7.1.21
uniprot
proteins
function
FUNCTION: Cell-cycle-regulated enzyme of importance in nucleotide metabolism. Catalyzes the first enzymatic step in the salvage pathway converting thymidine into thymidine monophosphate. Transcriptional regulation limits expression to the S phase of the cell cycle and transient expression coincides with the oscillation in the intracellular dTTP concentration. {ECO:0000250|UniProtKB:P04183}.
uniprot
proteins
mass_dalton
13511
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser-13 in mitosis. Phosphorylation of Ser-13 by CDK1 during mitosis reduces homotetramerization and catalytic efficiency when DNA replication is complete and intracellular TK1 is still present at a high level. {ECO:0000250|UniProtKB:P04183}.; PTM: Polyubiquitinated. Postmitosis, ubiquitination leads to proteasomal degradation. The KEN box sequence located at the C-terminal region targets for degradation by the anaphase promoting complex (APC/C) activated and rate-limited by FZR1. {ECO:0000250|UniProtKB:P04183}.
uniprot
proteins
protein_family
Thymidine kinase family
uniprot
proteins
pubmed
1777676
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
3479791
uniprot
proteins
sequence_length
121
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins