Smg5
entrez
229512
canonical
uniprot
Q6ZPY2
canonical
ensembl
ENSMUSG00000001415
resolver
ensp
ENSMUSP00000001451
resolver
ensp
ENSMUSP00000255141
resolver
genesymbol
Smg5
resolver
genesymbol_syn
BC024683
resolver
genesymbol_syn
Est1b
resolver
genesymbol_syn
Kiaa1089
resolver
uniprot
Q3UZS1
resolver
uniprot
Q497S2
resolver
uniprot
Q8R3S4
resolver
uniprot_entry
Q3UZS1_MOUSE
resolver
uniprot_entry
SMG5_MOUSE
resolver
uniprot_sec
Q497S2
resolver
uniprot_sec
Q8R3S4
resolver
amino_acid_sequence
MSQGPPPGESSEPEAKVLHTKRLYRAVVEAVHRLDLILCNKAAYQEVFKPENVSLRNKLRELCVKLMFLHPVDYGRKAEELLWRKVYYEVIQLIKTNKKHIHSRSTLECAYRTHLVAGIGFYQHLLLYIQSHYQLELQCCIDWTHVTDPLMGFKKPVSASGKEMDWAQMACHRCLVYLGDLSRYQNELAGVDTELLAERFYYQALSVAPQIGMPFNQLGTLAGSKYYNVEAMYCYLRCIQSEVSFEGAYGNLKRLYDKAAKMYHQLKKSETRKLSPSKKRCKDIKRLLVNFMYLQSLLQPKSSSVDSELTSLCQSVLEDFNLCLFYLPSSPNLGLTNEDEEECESGYAFLPDLLIFQMAIICLMGVHSLKRAGSKHYSAAIAFTLALFSHLINHVNIRLQAELEEGENPVSAFQSDGTDEPESKEALEKEEPEPEPPTVVPQADEGRKSRKHSRLSCLRRRRRHHPPKAGDDSDLSEGFESDSSHDSAQASDGSDSGSDKSLEGRGTAFDAETDSEMNSQESRSDLEDMEDEEGTRSPAQEPPQARSEVPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFRLAPTFSNLLLQPTTEPNSVASHRPCVNGDMDKPLEPASEDGSESEGSESSNRSCRNERSLQEKLQALMAEGLLPAVKVFLDWLRTNPDLIIVCAQSSQSLWNRLSVLLNLLPASAELQDSGLALCSEVQGLLEGCELPDLPASLLLPEDMALRNLPPLRAAHRRFNFDADRPLLSALEESVVRICCIRSFGHFVARLQGSILQFNPEVGIFVSIAQSEQESLLQQAQAQFRMAEEEARRNRLMRDMAQLRLQLEVSQLEGSLQQPKAQSAMSPYLIPDTQALCYHLPLIRQLATSGRFIIIIPRTVIDGLDLLKKEQPGARDGIRYLEAEFKKGNRYIRCQKEVGKSFERHKLKRQDADAWTLYKILDSCRQLTLAQGAGEEDPSGMVTIITGLHLDSPSALSGPMQAALQAAAHASVDVKNVLDFYRQWKEIG
uniprot
proteins
function
FUNCTION: Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
114071
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1017
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UPR3}. Nucleus {ECO:0000250|UniProtKB:Q9UPR3}. Note=Detected in cytoplasmic mRNA decay bodies. {ECO:0000250|UniProtKB:Q9UPR3}.
uniprot
proteins