Q8CFD9
uniprot
Q8CFD9
canonical
amino_acid_sequence
MAKVLLIVFIMVYAGSCAIWVSQPPEIRAQEGTTASLPCSFNASRGKAAIGSATWYQDKVAPGMELSNVTPGFRGRVASFSASQFIRGHKAGLLIQDIQSHDARIYVCRVEVLGLGVGTGNGTRLVVEKEPPQQASNAEPERAAYTSLLLRAGVYALSFLSVATGSVIYYQGKCLCHVGNTATPPTASEERF
uniprot
proteins
function
FUNCTION: Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG that promote DC maturation. {ECO:0000250|UniProtKB:O14931}.
uniprot
proteins
mass_dalton
20470
uniprot
proteins
protein_family
Natural cytotoxicity receptor (NCR) family
uniprot
proteins
pubmed
12180816
uniprot
proteins
pubmed
12548565
uniprot
proteins
pubmed
15060004
uniprot
proteins
sequence_length
192
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O14931}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 148..168; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins