SHISA6
entrez
388336
canonical
uniprot
Q6ZSJ9
canonical
ensembl
ENSG00000188803
resolver
ensp
ENSP00000387157
resolver
ensp
ENSP00000388659
resolver
ensp
ENSP00000390084
resolver
genesymbol
SHISA6
resolver
hgnc
HGNC:34491
resolver
uniprot
B3KXV5
resolver
uniprot
Q4PL63
resolver
uniprot_entry
SHSA6_HUMAN
resolver
uniprot_sec
B3KXV5
resolver
uniprot_sec
Q4PL63
resolver
amino_acid_sequence
MALRRLLLLLLLSLESLDLLPSVHGARGRAANRTLSAGGAAVGGRRAGGALARGGRELNGTARAPGIPEAGSRRGQPAAAVAAAASAAVTYETCWGYYDVSGQYDKEFECNNSESGYLYCCGTCYYRFCCKKRHEKLDQRQCTNYQSPVWVQTPSTKVVSPGPENKYDPEKDKTNFTVYITCGVIAFVIVAGVFAKVSYDKAHRPPREMNIHRALADILRQQGPIPIAHCERETISAIDTSPKENTPVRSSSKNHYTPVRTAKQTPEKPRMNNILTSATEPYDLSFSRSFQNLAHLPPSYESAVKTNPSKYSSLKRLTDKEADEYYMRRRHLPDLAARGTLPLNVIQMSQQKPLPRERPRRPIRAMSQDRVLSPDRGLPDEFSMPYDRILSDEQLLSTERLHSQDPLLSPERTAFPEQSLSRAISHTDVFVSTPVLDRYRMSKMHSHPSASNNSYATLGQSQTAAKRHAFASRRHNTVEQLHYIPGHHTCYTASKTEVTV
uniprot
proteins
function
FUNCTION: Involved in maintenance of high-frequency synaptic transmission at hippocampal CA3-CA1 synapses. Regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression. May play a role in self-renewal and differentiation of spermatogonial stem cells by inhibiting canonical Wnt signaling pathway. {ECO:0000250|UniProtKB:Q3UH99}.
uniprot
proteins
mass_dalton
55764
uniprot
proteins
protein_family
Shisa family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16473350
uniprot
proteins
pubmed
16625196
uniprot
proteins
sequence_length
500
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q3UH99}. Postsynaptic density {ECO:0000250|UniProtKB:Q3UH99}.
uniprot
proteins
transmembrane_region
TRANSMEM 175..195; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins