Mef2c
entrez
499497
canonical
uniprot
A0A096MJY4
canonical
ensembl
ENSRNOG00000033134
resolver
ensembl
ENSRNOG00055023316
resolver
ensembl
ENSRNOG00060000737
resolver
ensembl
ENSRNOG00065005566
resolver
ensp
ENSRNOP00000067948
resolver
ensp
ENSRNOP00000067963
resolver
ensp
ENSRNOP00000067970
resolver
ensp
ENSRNOP00000068094
resolver
ensp
ENSRNOP00000099728
resolver
ensp
ENSRNOP00055032537
resolver
ensp
ENSRNOP00060000208
resolver
ensp
ENSRNOP00065005788
resolver
enst
ENSRNOT00000075931
resolver
enst
ENSRNOT00000076136
resolver
enst
ENSRNOT00000076481
resolver
enst
ENSRNOT00000122974
resolver
enst
ENSRNOT00055040090
resolver
enst
ENSRNOT00060000861
resolver
enst
ENSRNOT00065008259
resolver
genesymbol
Mef2c
resolver
uniprot
A0A096MJ23
resolver
uniprot
A0A096MJ29
resolver
uniprot
A0A096MJD9
resolver
uniprot
A0ABK0L6U2
resolver
uniprot_entry
A0A096MJ23_RAT
resolver
uniprot_entry
A0A096MJ29_RAT
resolver
uniprot_entry
A0A096MJD9_RAT
resolver
uniprot_entry
A0ABK0L6U2_RAT
resolver
uniprot_entry
MEF2C_RAT
resolver
amino_acid_sequence
MGRKKIQITRIMDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNSTNKLFQYASTDMDKVLLKYTEYNEPHESRTNSDIVETLRKKGLNGCDSPDPDADDSVGHSPESEDKYRKINEDIDLMISRQRLCAVPPPNFEMPVTIPVSSHNSLVYSNPVSSLGNPNLLPLAHPSLQRNSMSPGVTHRPPSAGNTGGLMGGDLTSGAGTSAGNGYGNPRNSPGLLVSPGNLNKNIQAKSPPPMNLGMNNRKPDLRVLIPPGSKNTMPSVSEDVDLLLNQRINNSQSAQSLATPVVSVATPTLPGQGMGGYPSAISTTYGTEYSLSSADLSSLSGFNTASALHLGSVTGWQQQHLHNMPPSALSQLGACTSTHLSQSSNLSLPSTQSLNIKSEPVSPPRDRTTTPSRYPQHTRHEAGRSPVDSLSSCSSSYDGSDREDHRNEFHSPIGLTRPSPDERESPSVKRMRLSEGWAT
uniprot
proteins
function
FUNCTION: Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes (PubMed:15862299). Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). {ECO:0000250|UniProtKB:Q8CFN5, ECO:0000269|PubMed:15862299}.
uniprot
proteins
mass_dalton
51217
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser-59; which enhances DNA binding activity. Phosphorylated on Ser-396; which is required for Lys-391 sumoylation and inhibits transcriptional activity. {ECO:0000250}.; PTM: Acetylated by p300 on several sites in diffentiating myocytes. Acetylation on Lys-4 increases DNA binding and transactivation. {ECO:0000250}.; PTM: Sumoylated on Lys-391 with SUMO2 but not SUMO1; which represses transcriptional activity. {ECO:0000250}.; PTM: Proteolytically cleaved in cerebellar granule neurons on several sites by caspase 3 and caspase 7 following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation. {ECO:0000250}.
uniprot
proteins
protein_family
MEF2 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15862299
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
473
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15862299}. Cytoplasm, sarcoplasm {ECO:0000269|PubMed:15862299}.
uniprot
proteins