CALHM4
entrez
221301
canonical
uniprot
Q5JW98
canonical
ensembl
ENSG00000164451
resolver
ensp
ENSP00000357585
resolver
ensp
ENSP00000357586
resolver
ensp
ENSP00000385836
resolver
ensp
ENSP00000409556
resolver
ensp
ENSP00000487169
resolver
genesymbol
CALHM4
resolver
genesymbol_syn
C6orf78
resolver
genesymbol_syn
FAM26D
resolver
hgnc
HGNC:21094
resolver
uniprot
B0QZ25
resolver
uniprot
B0QZ27
resolver
uniprot
B4DTQ0
resolver
uniprot
Q96MK0
resolver
uniprot_entry
CAHM4_HUMAN
resolver
uniprot_sec
B0QZ25
resolver
uniprot_sec
B0QZ27
resolver
uniprot_sec
B4DTQ0
resolver
uniprot_sec
Q96MK0
resolver
amino_acid_sequence
MCPTLNNIVSSLQRNGIFINSLIAALTIGGQQLFSSSTFSCPCQVGKNFYYGSAFLVIPALILLVAGFALRSQMWTITGEYCCSCAPPYRRISPLECKLACLRFFSITGRAVIAPLTWLAVTLLTGTYYECAASEFASVDHYPMFDNVSASKREEILAGFPCCRSAPSDVILVRDEIALLHRYQSQMLGWILITLATIAALVSCCVAKCCSPLTSLQHCYWTSHLQNERELFEQAAEQHSRLLMMHRIKKLFGFIPGSEDVKHIRIPSCQDWKDISVPTLLCMGDDLQGHYSFLGNRVDEDNEEDRSRGIELKP
uniprot
proteins
function
FUNCTION: May assemble to form gap junction channel-like structures involved in intercellular communication. Channel gating and ion conductance are likely regulated by membrane lipids rather than by membrane depolarization or extracellular calcium levels. {ECO:0000269|PubMed:32374262}.
uniprot
proteins
mass_dalton
35060
uniprot
proteins
protein_family
CALHM family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
32374262
uniprot
proteins
sequence_length
314
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:32374262}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..37; /note="Helical; Name=S1"; /evidence="ECO:0000269|PubMed:32374262, ECO:0007744|PDB:6YTK"; TRANSMEM 49..71; /note="Helical; Name=S2"; /evidence="ECO:0000269|PubMed:32374262, ECO:0007744|PDB:6YTK"; TRANSMEM 104..129; /note="Helical; Name=S3"; /evidence="ECO:0000269|PubMed:32374262, ECO:0007744|PDB:6YTK"; TRANSMEM 184..207; /note="Helical; Name=S4"; /evidence="ECO:0000269|PubMed:32374262, ECO:0007744|PDB:6YTK
uniprot
proteins