Maf1
entrez
315093
canonical
uniprot
Q5XIH0
canonical
ensembl
ENSRNOG00000013514
resolver
ensembl
ENSRNOG00065009879
resolver
ensp
ENSRNOP00000018240
resolver
ensp
ENSRNOP00000089214
resolver
ensp
ENSRNOP00065012005
resolver
enst
ENSRNOT00000018240
resolver
enst
ENSRNOT00000098036
resolver
enst
ENSRNOT00065015884
resolver
genesymbol
Maf1
resolver
uniprot
A0A8L2Q923
resolver
uniprot_entry
A0A8L2Q923_RAT
resolver
uniprot_entry
MAF1_RAT
resolver
amino_acid_sequence
MKLLENSSFEAINSQLTVETGDAHIIGRIESYSCKMAGDDKHMFKQFCQEGQPHVLEALSPPQTSGLSPSRLSKSQGGEDESPLSDKCSRKTLFYLIATLNESFRPDYDFSTARSHEFSREPSLRWVVNAVNCSLFSAVREDFKALKPQLWNAVDEEICLAECDIYSYNPDLDSDPFGEDGSLWSFNYFFYNKRLKRIVFFSCRSISGSTYTPSEAGNALDLELGAEEVDEESGGGGGGGEGRAEETSTMEEDRVPVICM
uniprot
proteins
function
FUNCTION: Plays a role in the repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cellular stress conditions to balance the production of highly abundant tRNAs, 5S rRNA, and other small non-coding RNAs with cell growth and maintenance (By similarity). Also plays a key role in cell fate determination by promoting mesorderm induction and adipocyte differentiation (By similarity). Mechanistically, associates with the RNA polymerase III clamp and thereby impairs its recruitment to the complex made of the promoter DNA, TBP and the initiation factor TFIIIB. When nutrients are available and mTOR kinase is active, MAF1 is hyperphosphorylated and RNA polymerase III is engaged in transcription. Stress-induced MAF1 dephosphorylation results in nuclear localization, increased targeting of gene-bound RNA polymerase III and a decrease in the transcriptional readout. Additionally, may also regulate RNA polymerase I and RNA polymerase II-dependent transcription through its ability to regulate expression of the central initiation factor TBP (By similarity). {ECO:0000250|UniProtKB:Q9D0U6, ECO:0000250|UniProtKB:Q9H063}.
uniprot
proteins
mass_dalton
28922
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-60, Ser-68 and Ser-75; the major sites of phosphorylation. Nuclear accumulation correlates with a concomitant dephosphorylation. Phosphorylation may attenuate its RNA polymerase III-repressive function (By similarity). {ECO:0000250}.; PTM: Sumoylated with SUMO1 and SUMO2, mainly on Lys-35. Desumoylated by SENP1. SUMOylation promotes the ability of MAF1 to repress transcription and suppress colony formation (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
MAF1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
260
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H063}. Cytoplasm {ECO:0000250|UniProtKB:Q9H063}.
uniprot
proteins