GLYR1
entrez
84656
canonical
uniprot
Q49A26
canonical
ensembl
ENSG00000140632
resolver
ensp
ENSP00000322716
resolver
ensp
ENSP00000390276
resolver
ensp
ENSP00000468328
resolver
ensp
ENSP00000569253
resolver
ensp
ENSP00000569255
resolver
genesymbol
GLYR1
resolver
genesymbol_syn
HIBDL
resolver
genesymbol_syn
NDF
resolver
genesymbol_syn
NP60
resolver
genesymbol_syn
NPAC
resolver
hgnc
HGNC:24434
resolver
uniprot
B4DL47
resolver
uniprot
C9JJ40
resolver
uniprot
C9JJ60
resolver
uniprot
Q5U632
resolver
uniprot
Q6P1Q2
resolver
uniprot
Q6V3W7
resolver
uniprot
Q9BTI1
resolver
uniprot
Q9BXK2
resolver
uniprot
Q9NZ78
resolver
uniprot_entry
GLYR1_HUMAN
resolver
uniprot_entry
Q9NZ78_HUMAN
resolver
uniprot_sec
B4DL47
resolver
uniprot_sec
C9JJ40
resolver
uniprot_sec
C9JJ60
resolver
uniprot_sec
Q5U632
resolver
uniprot_sec
Q6P1Q2
resolver
uniprot_sec
Q6V3W7
resolver
uniprot_sec
Q9BTI1
resolver
uniprot_sec
Q9BXK2
resolver
amino_acid_sequence
MAAVSLRLGDLVWGKLGRYPPWPGKIVNPPKDLKKPRGKKCFFVKFFGTEDHAWIKVEQLKPYHAHKEEMIKINKGKRFQQAVDAVEEFLRRAKGKDQTSSHNSSDDKNRRNSSEERSRPNSGDEKRKLSLSEGKVKKNMGEGKKRVSSGSSERGSKSPLKRAQEQSPRKRGRPPKDEKDLTIPESSTVKGMMAGPMAAFKWQPTASEPVKDADPHFHHFLLSQTEKPAVCYQAITKKLKICEEETGSTSIQAADSTAVNGSITPTDKKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKCDLFIQEGARLGRTPAEVVSTCDITFACVSDPKAAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDCSSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEGLTLAQVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYIQKDLRLAIALGDAVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRAYIH
uniprot
proteins
function
FUNCTION: Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression (PubMed:23260659, PubMed:30970244). Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation (PubMed:29759984, PubMed:30970244). Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA (PubMed:20850016, PubMed:30970244). Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes (PubMed:23260659, PubMed:29759984, PubMed:30970244). Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 (PubMed:29759984). With GATA4, co-binds a defined set of heart development genes and coregulates their expression during cardiomyocyte differentiation (PubMed:35182466). Regulates p38 MAP kinase activity by mediating stress activation of MAPK14/p38alpha and specifically regulating MAPK14 signaling (PubMed:16352664). Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 (PubMed:16352664). The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (PubMed:16352664). {ECO:0000269|PubMed:16352664, ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:29759984, ECO:0000269|PubMed:30970244, ECO:0000269|PubMed:35182466}.
uniprot
proteins
mass_dalton
60547
uniprot
proteins
mutagenesis
MUTAGEN 214; /note="D->A: Slightly reduced stimulation of KDM1B demethylase activity, but normal KDM1B-binding."; /evidence="ECO:0000269|PubMed:23260659"; MUTAGEN 216; /note="H->A: Slightly reduced stimulation of KDM1B demethylase activity, but normal KDM1B-binding."; /evidence="ECO:0000269|PubMed:23260659"; MUTAGEN 217; /note="F->A: Abolished stimulation of KDM1B demethylase activity, reduced affinity for histone H3 of the dimer with KDM1B, but normal KDM1B-binding."; /evidence="ECO:0000269|PubMed:23260659"; MUTAGEN 219; /note="H->A: Impaired KDM1B-binding and abolished stimulation of KDM1B demethylase activity; when associated with A-223."; /evidence="ECO:0000269|PubMed:23260659"; MUTAGEN 220..222; /note="FLL->AAA: Impaired KDM1B-binding and abolished stimulation of KDM1B demethylase activity."; /evidence="ECO:0000269|PubMed:23260659"; MUTAGEN 223; /note="S->A: Impaired KDM1B-binding and abolished stimulation of KDM1B demethylase activity; when associated with A-219."; /evidence="ECO:0000269|PubMed:23260659"; MUTAGEN 437; /note="M->K: Loss of tetramerization and protein stability."; /evidence="ECO:0000269|PubMed:30970244"; MUTAGEN 437; /note="M->N: No effect on tetramerization or protein stability."; /evidence="ECO:0000269|PubMed:30970244
uniprot
proteins
protein_family
HIBADH-related family
uniprot
proteins
protein_family
NP60 subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
16352664
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20850016
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23260659
uniprot
proteins
pubmed
23357850
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
29759984
uniprot
proteins
pubmed
30970244
uniprot
proteins
pubmed
31408337
uniprot
proteins
pubmed
35182466
uniprot
proteins
sequence_length
553
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16352664}. Chromosome {ECO:0000269|PubMed:29759984, ECO:0000269|PubMed:30970244}. Note=Found in actively RNAPolII-transcribed gene bodies. {ECO:0000269|PubMed:30970244, ECO:0000269|PubMed:31408337}.
uniprot
proteins