Pitx2
entrez
54284
canonical
uniprot
Q9R0W1
canonical
ensembl
ENSRNOG00000010681
resolver
ensembl
ENSRNOG00055026980
resolver
ensembl
ENSRNOG00060003311
resolver
ensembl
ENSRNOG00065014191
resolver
ensp
ENSRNOP00000043402
resolver
ensp
ENSRNOP00000046259
resolver
ensp
ENSRNOP00000084208
resolver
genesymbol
Pitx2
resolver
genesymbol_syn
Ptx2
resolver
uniprot_entry
PITX2_RAT
resolver
amino_acid_sequence
MNCMKGPLPLEHRAAGTKLSAASSPFCHHTQALAMASVLAPGQPRSLDASKHRLEVHTISDTSSPEVAEKDKGQQGKNEDVGAEDPSKKKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGFGPQFNGLMQPYDDMYPGYSYNNWAAKGLTSASLSTKSFPFFNSMNVNPLSSQSMFSPPNSISSMSMSSSMVPSAVTGVPGSSLNSLNNLNNLSSPSLNSAVPTPACPYAPPTPPYVYRDTCNSSLASLRLKAKQHSSFGYASVQNPASNLSACQYAVDRPV
uniprot
proteins
function
FUNCTION: May play a role in myoblast differentiation. When unphosphorylated, associates with an ELAVL1-containing complex, which stabilizes cyclin mRNA and ensuring cell proliferation. Phosphorylation by AKT2 impairs this association, leading to CCND1 mRNA destabilization and progression towards differentiation. Involved in the establishment of left-right asymmetry in the developing embryo. {ECO:0000250|UniProtKB:P97474}.
uniprot
proteins
mass_dalton
35758
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Thr-97 by AKT2, but not AKT1. Phosphorylation at Thr-97 impairs its association with a CCND1 mRNA-stabilizing complex, thus shortening the half-life of CCND1. {ECO:0000250|UniProtKB:P97474}.
uniprot
proteins
protein_family
Bicoid subfamily
uniprot
proteins
protein_family
Paired homeobox family
uniprot
proteins
pubmed
11032870
uniprot
proteins
pubmed
9748586
uniprot
proteins
sequence_length
324
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Cytoplasm {ECO:0000250|UniProtKB:P97474}.
uniprot
proteins