Ros1
entrez
25346
canonical
uniprot
Q63132
canonical
ensembl
ENSRNOG00000000406
resolver
ensp
ENSRNOP00000000459
resolver
ensp
ENSRNOP00000068996
resolver
enst
ENSRNOT00000080444
resolver
genesymbol
Ros1
resolver
uniprot
A0A8L2UPK7
resolver
uniprot
Q63130
resolver
uniprot
Q63131
resolver
uniprot_entry
A0A8L2UPK7_RAT
resolver
uniprot_entry
ROS1_RAT
resolver
uniprot_sec
Q63130
resolver
uniprot_sec
Q63131
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by dephosphorylation by PTPN6. {ECO:0000250|UniProtKB:Q78DX7}.
uniprot
proteins
amino_acid_sequence
MKRIRWLTPKPATFVVLGCVWISVAQGTILSSCLTSCVTNLGRQLDSGTRYNLSEACIQGCQFWNSIDQEKCALKCNDTYVTICERESCEVGCSNAEGSYEEEVLDNTELPTAPFASSIGSNGVTLRWNPANISGVKYIIQWKYAQLPGSWAYTETVSKLSYMVEPLHPFTEYIFRVVWIFTAQLHLYSPPSPSYRTHPYGVPETAPFITNIESSSPDTVEVSWAPPYFPGGPILGYNLRLISKTQKLDSGTQRTSFQFYSTLPNTTYRFSIAAVNEVGEGPEAESMITTPSPAVQEEEQWLFLSRKTSLRKRSLKYLVDEAHCLWSDAIRHNITGISVNTQQEVVYFSEGTIIWMKGAANMSDVSDLRIFYRGSALVSSISVDWLYQRMYFIMDNRVHVCDLKHCSNLEEITPFSIVAPQKVVVDSYNGYVFYLLRDGIYRVHLPLPSVRDTKAVRIVESGTLKDFAVKPQSKRIIYFNGTMQVFMSTFLDGSAFHRVLPWVPLADVKSFACENNDFLITDGKAIFQQDSLSFNEFIVGCDLSHIEEFGFGNLVIFGSSVQSYPLPGHPQEVSVLFGSREALIQWKPPILAIGASPSAWQNWTYEVKVSSQDILETTQVFLNISRTVLNVPKLQSSTKYMVSVRASSPKGPGPWSEPSVGTTLVPATEPPFIMAVKEDGLWSKPLSSFGPGEFLSSDVGNVSDMDWYNNSLYYSDTKGNVYVRPLNGMDISENYHISSIAGACALAFEWLGHFLYWAGKTYVIQRQSVLTGHTDIVTHVKLLVNDMAVDPVGGYLYWTTLYSVESTRLNGESSLVLQAQPWLSGKKVIALTLDLSDGLLYWLVQDNQCIHLYTAVLRGWSGADATITEFAAWSTSEISQNALMYYSGRLFWINGFRIITAQEIGQRTSVSVSEPGKFNQFTIIQTSLKPLPGNFSSTPTVIPDSVQESSFRIEGHTSSFRILWNEPPAVDWGIVFYSVEFSAHSKFLAIEQQSLPVFTVEGLEPYALFNLSVTPYTYWGKGQKTSLSFRAPESVPSAPENPRIFILSLGRYTRKNEVVVEFRWNKPKHENGVLTKSEIFYHISKQSGTNKSTEDWVSVSVTPPVMSFQLEAMSPGYIVSFQVRVFTSKGPGPFSDIVMSKTSEIKPCPYLISLLGNKIEFLDMDQNQVVWTFSLEGAVSTVGYTADDEMGYFAQGDALFLLNLHNHSSSKLFQDVLASDIAVIAVDWIARHLYFALKASQDGTQIFDVDLEHKVKSPREVKICKSHTAIISFSMYPLLSRLYWTEVSDLGYQMFYCNISSHTLHHVLQPKASNQHGRRQCSCNVTESELSGAMTVDTSDPDRPWIYFTKQQEIWAMDLEGCQCWKVIMVPATPGKRIISLTVDGEFIYWITTMKDDTEIYQAKKGSGAILSQVKAPRSKHILAYSSALQPFPDKAYLSVASNMVEASILNATNTSLILKLPPVKTNLTWHGITTPTSTYLVYYMEANRANSSDRKHNMLESQENVARIEGLQPFSTYVIQIAVKNYYSDPLEHLSLGKEIQGKTKSGVPGAVCHINATVLSDTSLLVFWTESHKPNGPKELVRYQLVMSYLAPIPETPLRQDEFPSARLSLLVTKLSGGQQYVLKILACHSEEMWCTESHPVSVNMFDTPEKPSALVPENTSLLLDWKAPSNANLTRFWFELQKWKYSEFYHVKASCSQGPVYVCNIANLQPYTPYNIRVVVVYTTGENSSSIPESFKTKAGVPSKPGIPKLLEGSKNSIQWEKAEDNGNRLMYYTLEVRKSISNDSRDQSLRWTAVFNGSCSSICTWRSKNLKGTFQFRAVASNAIGFGEYSEISEDITLVEDGFWITETSFILTIIVGIFLVATVPLTFVWHRSLKNHKATKEGLSVLNDNDQELAELRGLAAGVGLANACYAVHTLPTQEEIESLPAFPREKLSLRLLLGSGAFGEVYEGTAVDILGRGSGEIKVAVKTLKKGSTDQEKIEFLKEAHLMSKFNHPNILKQLGVCLLSEPQYIILELMEGGDLLSYLRKARGTTLSGPLLTLADLVELCVDISKGCVYLEQMHFIHRDLAARNCLVSVKDYTSPRVVKIGDFGLAREIYKHDYYRKRGEGLLPVRWMAPENLMDGIFTSQSDVWSFGILVWEILTLGHQPYPAHSNLDVLNYVQAGGRLEPPRNCPDDLWNLMFRCWAQEPDQRPTFYNIQDQLQLFRNVSLNNVSHCGQAAPAGGVINKGFEGEDNEMATLNSDDTMPVALMETRNQEGLNYMVLATKCSQSEDRYEGPLGSKESGLHDLKKDERQPADKDFCQQPQVAYGSPGHSEGLNYACLAHSGHGDVSE
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. NELL2 is an endogenous ligand for ROS1. Upon endogenous stimulation by NELL2, ROS1 activates the intracellular signaling pathway and triggers epididymal epithelial differentiation and subsequent sperm maturation (By similarity). May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2 (By similarity). {ECO:0000250|UniProtKB:P08922, ECO:0000250|UniProtKB:Q78DX7}.
uniprot
proteins
mass_dalton
261656
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Probably autophosphorylates. Phosphorylation at Tyr-2266 is required for the interaction with PTPN6 that mediates ROS1 dephosphorylation (By similarity). Phosphorylation at Tyr-2266 stimulates the kinase activity and the activation of the ERK1 signaling cascade (By similarity). Phosphorylation at Tyr-2266 and/or Tyr-2325 recruits PTPN11 (By similarity). {ECO:0000250|UniProtKB:P08922, ECO:0000250|UniProtKB:Q78DX7}.
uniprot
proteins
protein_family
Insulin receptor subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
2139140
uniprot
proteins
sequence_length
2338
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 1854..1874; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins