Gpx8
entrez
69590
canonical
uniprot
Q9D7B7
canonical
ensembl
ENSMUSG00000021760
resolver
ensp
ENSMUSP00000022282
resolver
ensp
ENSMUSP00000156385
resolver
enst
ENSMUST00000022282
resolver
enst
ENSMUST00000231962
resolver
genesymbol
Gpx8
resolver
uniprot
A0A338P7G6
resolver
uniprot
Q8VE68
resolver
uniprot_entry
A0A338P7G6_MOUSE
resolver
uniprot_entry
GPX8_MOUSE
resolver
uniprot_sec
Q8VE68
resolver
amino_acid_sequence
MEPFAAYPLKCSGPKAKIFAVLLSMVLCTVMLFLLQLKFLKPRTNSFYSFEVKDAKGRTVSLEKFKGKASLVVNVASDCRFTDKSYQTLRELHKEFGPYHFNVLAFPCNQFGESEPKSSKEVESFARQNYGVTFPIFHKIKILGPEAEPAFRFIVDSSKKEPRWNFWKYLVNPEGQVVKFWRPEEPLEAIRPHVSQMIGQIILKKKEDL
uniprot
proteins
ec_number
5.3.4.1
uniprot
proteins
function
FUNCTION: Acts as an endoplasmic reticulum (ER) thiol peroxidase that maintains ER redox homeostasis and protects the cytosol from ER-derived H(2)O(2). Functions in a redox relay with ERO1A, using ERO1A-generated H(2)O(2) to drive PDI oxidation, linking peroxide detoxification to productive disulfide formation. Modulates endoplasmic reticulum Ca(2+) levels mainly through SERCA pump activity and partially by influencing passive Ca(2+) leakage. {ECO:0000250|UniProtKB:Q8TED1}.
uniprot
proteins
mass_dalton
24148
uniprot
proteins
protein_family
Glutathione peroxidase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
209
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8TED1}. Note=Also enriched in mitochondria-associated membranes (MAM). {ECO:0000250|UniProtKB:Q8TED1}.
uniprot
proteins
transmembrane_region
TRANSMEM 18..40; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins