PDGFA
entrez
5154
canonical
uniprot
P04085
canonical
ensembl
ENSG00000197461
resolver
ensp
ENSP00000346508
resolver
ensp
ENSP00000383889
resolver
ensp
ENSP00000571598
resolver
genesymbol
PDGFA
resolver
genesymbol_syn
PDGF1
resolver
hgnc
HGNC:8799
resolver
uniprot
B5BU73
resolver
uniprot_entry
PDGFA_HUMAN
resolver
uniprot_sec
B5BU73
resolver
amino_acid_sequence
MRTLACLLLLGCGYLAHVLAEEAEIPREVIERLARSQIHSIRDLQRLLEIDSVGSEDSLDTSLRAHGVHATKHVPEKRPLPIRRKRSIEEAVPAVCKTRTVIYEIPRSQVDPTSANFLIWPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQVRLEEHLECACATTSLNPDYREEDTGRPRESGKKRKRKRLKPT
uniprot
proteins
function
FUNCTION: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
24043
uniprot
proteins
protein_family
PDGF/VEGF growth factor family
uniprot
proteins
pubmed
10358027
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
1317862
uniprot
proteins
pubmed
1612586
uniprot
proteins
pubmed
18483217
uniprot
proteins
pubmed
19054851
uniprot
proteins
pubmed
20534510
uniprot
proteins
pubmed
2832727
uniprot
proteins
pubmed
3422746
uniprot
proteins
pubmed
3614363
uniprot
proteins
pubmed
3614364
uniprot
proteins
pubmed
3666150
uniprot
proteins
pubmed
3754619
uniprot
proteins
pubmed
8486521
uniprot
proteins
sequence_length
211
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted. Note=Released by platelets upon wounding.
uniprot
proteins