Ctdsp1
entrez
227292
canonical
uniprot
P58466
canonical
ensembl
ENSMUSG00000026176
resolver
ensp
ENSMUSP00000027367
resolver
ensp
ENSMUSP00000191821
resolver
enst
ENSMUST00000027367
resolver
genesymbol
Ctdsp1
resolver
genesymbol_syn
Nif3
resolver
genesymbol_syn
Nliif
resolver
uniprot
Q5I0X8
resolver
uniprot_entry
CTDS1_MOUSE
resolver
uniprot_entry
Q5I0X8_MOUSE
resolver
amino_acid_sequence
MDSSAVITQISKEEARGPLRGKGDQKSAVSQKPRSRGILHSLFCCVCRDDGEPLPAHSGAPLLVEENGAIPKHTPVQYLLPEAKAQDSDKICVVIDLDETLVHSSFKPVNNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGAFRARLFRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWFDNMSDTELHDLLPFFEQLSRVDDVYSVLRQPRPGS
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation (By similarity). Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. {ECO:0000250, ECO:0000269|PubMed:15681389}.
uniprot
proteins
mass_dalton
29266
uniprot
proteins
mutagenesis
MUTAGEN 96; /note="D->E: Leads to enhanced neuronal differentiation of stem cells; when associated with N-98."; /evidence="ECO:0000269|PubMed:15681389"; MUTAGEN 98; /note="D->N: Leads to enhanced neuronal differentiation of stem cells; when associated with E-96."; /evidence="ECO:0000269|PubMed:15681389
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15681389
uniprot
proteins
sequence_length
261
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins