DDAH1
entrez
23576
canonical
uniprot
O94760
canonical
ensembl
ENSG00000153904
resolver
ensp
ENSP00000284031
resolver
ensp
ENSP00000411189
resolver
ensp
ENSP00000488725
resolver
enst
ENST00000633113
resolver
genesymbol
DDAH1
resolver
genesymbol_syn
DDAH
resolver
genesymbol_syn
HEL-S-16
resolver
hgnc
HGNC:2715
resolver
uniprot
A0A0J9YY78
resolver
uniprot
A1NXE2
resolver
uniprot
B1AKK2
resolver
uniprot
B2R644
resolver
uniprot
B4DGT0
resolver
uniprot
B4DYP1
resolver
uniprot
B4E3V1
resolver
uniprot
Q5HYC8
resolver
uniprot
Q86XK5
resolver
uniprot_entry
A0A0J9YY78_HUMAN
resolver
uniprot_entry
B2R644_HUMAN
resolver
uniprot_entry
B4DGT0_HUMAN
resolver
uniprot_entry
B4DYP1_HUMAN
resolver
uniprot_entry
B4E3V1_HUMAN
resolver
uniprot_entry
DDAH1_HUMAN
resolver
uniprot_sec
A1NXE2
resolver
uniprot_sec
B1AKK2
resolver
uniprot_sec
Q5HYC8
resolver
uniprot_sec
Q86XK5
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by zinc ions (By similarity). Enzyme purified in the absence of 1,10-phenanthroline contains on average 0.4 zinc atoms per subunit. Inhibited by 4-hydroxy-nonenal through the formation of a covalent adduct with His-173. Competitively inhibited by N(5)-iminopropyl-ornithine. {ECO:0000250, ECO:0000269|PubMed:18171027, ECO:0000269|PubMed:19663506}.
uniprot
proteins
amino_acid_sequence
MAGLGHPAAFGRATHAVVRALPESLGQHALRSAKGEEVDVARAERQHQLYVGVLGSKLGLQVVELPADESLPDCVFVEDVAVVCEETALITRPGAPSRRKEVDMMKEALEKLQLNIVEMKDENATLDGGDVLFTGREFFVGLSKRTNQRGAEILADTFKDYAVSTVPVADGLHLKSFCSMAGPNLIAIGSSESAQKALKIMQQMSDHRYDKLTVPDDIAANCIYLNIPNKGHVLLHRTPEEYPESAKVYEKLKDHMLIPVSMSELEKVDGLLTCCSVLINKKVDS
uniprot
proteins
ec_number
3.5.3.18
uniprot
proteins
function
FUNCTION: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. {ECO:0000269|PubMed:18171027, ECO:0000269|PubMed:19663506, ECO:0000269|PubMed:21493890, ECO:0000269|PubMed:37296100}.
uniprot
proteins
mass_dalton
31122
uniprot
proteins
mutagenesis
MUTAGEN 30; /note="L->A: Reduces enzyme activity and affinity for asymmetric dimethylarginine about 12-fold."; /evidence="ECO:0000269|PubMed:19663506"; MUTAGEN 78; /note="E->A: Reduces enzyme activity about 1000-fold, and affinity for asymmetric dimethylarginine about 100-fold."; /evidence="ECO:0000269|PubMed:19663506"; MUTAGEN 271; /note="L->G: Reduces enzyme activity about 10-fold, and affinity for asymmetric dimethylarginine about 7-fold."; /evidence="ECO:0000269|PubMed:19663506
uniprot
proteins
protein_family
DDAH family
uniprot
proteins
pubmed
10493931
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17273169
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18171027
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19663506
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21493890
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
37296100
uniprot
proteins
pubmed
9874257
uniprot
proteins
sequence_length
285
uniprot
proteins