RTN1
entrez
6252
canonical
uniprot
Q16799
canonical
ensembl
ENSG00000139970
resolver
ensp
ENSP00000267484
resolver
ensp
ENSP00000340716
resolver
ensp
ENSP00000378525
resolver
enst
ENST00000395090
resolver
genesymbol
RTN1
resolver
genesymbol_syn
NSP
resolver
hgnc
HGNC:10467
resolver
uniprot
A8K3B9
resolver
uniprot
A8MT72
resolver
uniprot
Q16800
resolver
uniprot
Q16801
resolver
uniprot
Q5BKZ4
resolver
uniprot
Q9BQ59
resolver
uniprot_entry
A8K3B9_HUMAN
resolver
uniprot_entry
A8MT72_HUMAN
resolver
uniprot_entry
RTN1_HUMAN
resolver
uniprot_sec
Q16800
resolver
uniprot_sec
Q16801
resolver
uniprot_sec
Q5BKZ4
resolver
uniprot_sec
Q9BQ59
resolver
amino_acid_sequence
MAAPGDPQDELLPLAGPGSQWLRHRGEGENEAVTPKGATPAPQAGEPSPGLGARAREAASREAGSGPARQSPVAMETASTGVAGVSSAMDHTFSTTSKDGEGSCYTSLISDICYPPQEDSTYFTGILQKENGHVTISESPEELGTPGPSLPDVPGIESRGLFSSDSGIEMTPAESTEVNKILADPLDQMKAEAYKYIDITRPEEVKHQEQHHPELEDKDLDFKNKDTDISIKPEGVREPDKPAPVEGKIIKDHLLEESTFAPYIDDLSEEQRRAPQITTPVKITLTEIEPSVETTTQEKTPEKQDICLKPSPDTVPTVTVSEPEDDSPGSITPPSSGTEPSAAESQGKGSISEDELITAIKEAKGLSYETAENPRPVGQLADRPEVKARSGPPTIPSPLDHEASSAESGDSEIELVSEDPMAAEDALPSGYVSFGHVGGPPPSPASPSIQYSILREEREAELDSELIIESCDASSASEESPKREQDSPPMKPSALDAIREETGVRAEERAPSRRGLAEPGSFLDYPSTEPQPGPELPPGDGALEPETPMLPRKPEEDSSSNQSPAATKGPGPLGPGAPPPLLFLNKQKAIDLLYWRDIKQTGIVFGSFLLLLFSLTQFSVVSVVAYLALAALSATISFRIYKSVLQAVQKTDEGHPFKAYLELEITLSQEQIQKYTDCLQFYVNSTLKELRRLFLVQDLVDSLKFAVLMWLLTYVGALFNGLTLLLMAVVSMFTLPVVYVKHQAQIDQYLGLVRTHINAVVAKIQAKIPGAKRHAE
uniprot
proteins
function
FUNCTION: Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity. {ECO:0000269|PubMed:15286784}.
uniprot
proteins
mass_dalton
83618
uniprot
proteins
post_translational_modification
PTM: Isoforms RTN1-A and RTN1-B are phosphorylated.
uniprot
proteins
pubmed
12873973
uniprot
proteins
pubmed
15286784
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15922294
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25612671
uniprot
proteins
pubmed
7685762
uniprot
proteins
pubmed
8833145
uniprot
proteins
pubmed
9560466
uniprot
proteins
sequence_length
776
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12873973}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:12873973}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 603..623; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 705..725; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins