Polr1e
entrez
64424
canonical
uniprot
Q8K202
canonical
ensembl
ENSMUSG00000028318
resolver
ensp
ENSMUSP00000029999
resolver
ensp
ENSMUSP00000121007
resolver
genesymbol
Polr1e
resolver
genesymbol_syn
Paf53
resolver
genesymbol_syn
Praf1
resolver
uniprot
B1AXQ6
resolver
uniprot
B1AXQ7
resolver
uniprot
Q3V1B9
resolver
uniprot
Q62034
resolver
uniprot
Q8BQG9
resolver
uniprot_entry
Q3V1B9_MOUSE
resolver
uniprot_entry
RPA49_MOUSE
resolver
uniprot_sec
B1AXQ6
resolver
uniprot_sec
B1AXQ7
resolver
uniprot_sec
Q62034
resolver
uniprot_sec
Q8BQG9
resolver
amino_acid_sequence
MATLESPGMDDQAGDTETEALQSARWLYCGEPDDRQKAVLVQFSNGKLQNPGDMRFTLYNSTDLVNPRQRSHRIVAAETDRLSYVGNNFGTGALKCNALCRHFVGILNKTSGQMEVYDAELFNMQPLFAGMGTEVIKLGGQHLYLLAFCQPSKNLAEAGDLLLSRHRQGHCIAVLLDDDAIEREPPLENQNKTFRDKLDSCIEAFGSTKQKRSLNSRRMNKVGSESLNLSVAKAAESIIDTKGVNALVSDAMQDDLQDGVLYLPPCYADAAKPEDVYRFEDILSPAEYDALESPSEAFRKVTSEDILKMIEENSHCSYVIEMLKSLPIDEVHRNRQARSIWFLDALIRFRAQKVIKGKRALGPGIPHIINTKLLKQFTCLTYNNGRLQNLISSSMRAKITSYAIILALHINNFQVDLTALQKDLKLSEKRMIEIAKAMRLKISKQKVSLADGREESHRLGTLSVPLPPAQNSDRQSKRRKMN
uniprot
proteins
function
FUNCTION: Component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates (PubMed:8641287, PubMed:9254723). Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF (PubMed:8641287). {ECO:0000269|PubMed:8641287, ECO:0000269|PubMed:9254723}.
uniprot
proteins
mass_dalton
54034
uniprot
proteins
post_translational_modification
PTM: Acetylated at Lys-436 by CREBBP/CBP, leading to decreased RNA polymerase I transcription. In normal conditions, deacetylated by SIRT7, promoting the association of RNA polymerase I with the rDNA promoter region and coding region. In response to stress, SIRT7 is released from nucleoli leading to hyperacetylation of POLR1E/PAF53 and decreased association of RNA polymerase I with the rDNA promoter region. {ECO:0000250|UniProtKB:Q9GZS1}.
uniprot
proteins
protein_family
Eukaryotic RPA49/POLR1E RNA polymerase subunit family
uniprot
proteins
pubmed
15226435
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
8641287
uniprot
proteins
pubmed
9254723
uniprot
proteins
sequence_length
482
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:8641287, ECO:0000269|PubMed:9254723}.
uniprot
proteins