Rabl3
entrez
67657
canonical
uniprot
Q9D4V7
canonical
ensembl
ENSMUSG00000022827
resolver
ensp
ENSMUSP00000023524
resolver
ensp
ENSMUSP00000271766
resolver
genesymbol
Rabl3
resolver
uniprot
Q8BMU2
resolver
uniprot
Q9D0M6
resolver
uniprot_entry
RABL3_MOUSE
resolver
uniprot_sec
Q8BMU2
resolver
uniprot_sec
Q9D0M6
resolver
amino_acid_sequence
MASLDRVKVLVLGDSGVGKSSLVHLLCHNQVLGNPSWTVGCSVDIRVHDYKEGTPEEKTYYIELWDVGGSVGSASSVKSTRAVFYNSVNGIILVHDLTNKKSSQNLYRWSLEVLNRDAVPTGVLVTNGDYDREQFADNQIPLLVIGTKLDQIHETKRHEVLIRTAFLAEDFNAEEINLDCTNPRSSAAGSSNAVKLSRFFDKVIEKRYFFREGNQIPGFSDRKRFGGGALKNFHCD
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Small GTPase required for KRAS signaling regulation and modulation of cell proliferation (PubMed:31406347). Regulator of KRAS prenylation, and probably prenylation of other small GTPases (By similarity). Required for lymphocyte development and function (PubMed:32220963). Not required for myeloid cell development (PubMed:32220963). Interacts with Rab11 to promote ciliary vesicle formation at the mother centriole, thereby regulating early ciliogenesis. The GTP-binding capacity of RABL3 is essential for ciliogenesis (By similarity). {ECO:0000250|UniProtKB:Q5HYI8, ECO:0000269|PubMed:31406347, ECO:0000269|PubMed:32220963}.
uniprot
proteins
mass_dalton
26298
uniprot
proteins
mutagenesis
MUTAGEN 43..46; /note="Missing: In xiamen; reduced Rabl3 expression, reduced interaction with Gpr89, reduced thermal stability, reduced frequency of CD3+ T cells, increased CD4+-to-CD8+ T cell ratio, higher CD44 expression in CD8+ T cells and increased B cell-to-T cell ratio."; /evidence="ECO:0000269|PubMed:32220963
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31406347
uniprot
proteins
pubmed
32220963
uniprot
proteins
sequence_length
236
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q5HYI8}. Golgi apparatus {ECO:0000250|UniProtKB:Q5HYI8}. Note=Accumulates around the centrosome during early ciliogenesis. {ECO:0000250|UniProtKB:Q5HYI8}.
uniprot
proteins