DAOA
entrez
267012
canonical
uniprot
P59103
canonical
ensembl
ENSG00000182346
resolver
ensp
ENSP00000365103
resolver
ensp
ENSP00000453831
resolver
ensp
ENSP00000469539
resolver
ensp
ENSP00000470244
resolver
ensp
ENSP00000472260
resolver
enst
ENST00000595812
resolver
genesymbol
DAOA
resolver
genesymbol_syn
G72
resolver
hgnc
HGNC:21191
resolver
uniprot
A2T115
resolver
uniprot
A6NKG7
resolver
uniprot
M0QY23
resolver
uniprot
Q0VAE6
resolver
uniprot
Q5VX59
resolver
uniprot
Q86Y17
resolver
uniprot
Q8IWM4
resolver
uniprot_entry
A2T115_HUMAN
resolver
uniprot_entry
DAOA_HUMAN
resolver
uniprot_entry
M0QY23_HUMAN
resolver
uniprot_sec
A6NKG7
resolver
uniprot_sec
Q0VAE6
resolver
uniprot_sec
Q5VX59
resolver
uniprot_sec
Q86Y17
resolver
uniprot_sec
Q8IWM4
resolver
amino_acid_sequence
MLEKLMGADSLQLFRSRYTLGKIYFIGFQRSILLSKSENSLNSIAKETEEGRETVTRKEGWKRRHEDGYLEMAQRHLQRSLCPWVSYLPQPYAELEEVSSHVGKVFMARNYEFLAYEASKDRRQPLERMWTCNYNQQKDQSCNHKEITSTKAE
uniprot
proteins
disease_involvement
DISEASE: Schizophrenia (SCZD) [MIM:181500]: A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. {ECO:0000269|PubMed:12364586}. Note=Disease susceptibility may be associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: May suppress DAO (D-amino acid oxidase) and SOD1 activity and promote their degradation (PubMed:18544534, PubMed:20521334, PubMed:21679769, PubMed:30037290). Has conversely also been suggested to function as a DAO activator (PubMed:12364586, PubMed:24362575, PubMed:29114206). May stimulate the degradation of DDO (D-aspartate oxidase) (PubMed:37805834). May play a role in mitochondrial fission (PubMed:17684499). {ECO:0000269|PubMed:12364586, ECO:0000269|PubMed:17684499, ECO:0000269|PubMed:18544534, ECO:0000269|PubMed:20521334, ECO:0000269|PubMed:21679769, ECO:0000269|PubMed:24362575, ECO:0000269|PubMed:29114206, ECO:0000269|PubMed:30037290, ECO:0000269|PubMed:37805834}.
uniprot
proteins
mass_dalton
18108
uniprot
proteins
pubmed
12364586
uniprot
proteins
pubmed
12647258
uniprot
proteins
pubmed
14759258
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17684499
uniprot
proteins
pubmed
18544534
uniprot
proteins
pubmed
20521334
uniprot
proteins
pubmed
21679769
uniprot
proteins
pubmed
24362575
uniprot
proteins
pubmed
25078755
uniprot
proteins
pubmed
29114206
uniprot
proteins
pubmed
30037290
uniprot
proteins
pubmed
37805834
uniprot
proteins
sequence_length
153
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18544534}. Golgi apparatus {ECO:0000269|PubMed:12364586, ECO:0000269|PubMed:18544534}. Mitochondrion {ECO:0000269|PubMed:17684499, ECO:0000269|PubMed:25078755}. Note=May transiently pass through the Golgi apparatus. {ECO:0000269|PubMed:18544534}.
uniprot
proteins