OPRPN
entrez
58503
canonical
uniprot
Q99935
canonical
ensembl
ENSG00000171199
resolver
ensp
ENSP00000382485
resolver
enst
ENST00000399575
resolver
genesymbol
OPRPN
resolver
genesymbol_syn
BPLP
resolver
genesymbol_syn
PROL1
resolver
hgnc
HGNC:17279
resolver
uniprot
A8MZ07
resolver
uniprot
P85047
resolver
uniprot_entry
PROL1_HUMAN
resolver
uniprot_sec
A8MZ07
resolver
uniprot_sec
P85047
resolver
amino_acid_sequence
MKLTFFLGLLALISCFTPSESQRFSRRPYLPGQLPPPPLYRPRWVPPSPPPPYDSRLNSPLSLPFVPGRVPPSSFSRFSQAVILSQLFPLESIRQPRLFPGYPNLHFPLRPYYVGPIRILKPPFPPIPFFLAIYLPISNPEPQINITTADTTITTNPPTTATATTSTSTKPTMTISSSTVPISSTPEPATSISAATPAASTENTTQILANRPHTVLLNATVQVTTSNQTILSSPAFKSFWQKLFAIFG
uniprot
proteins
function
FUNCTION: Opiorphin is an endogenous inhibitor of neprilysin and aminopeptidase N. Inhibits the breakdown of substance P, Mca-BK2 and Met-enkephalin by neprilysin in vitro with IC(50) values of 29 uM, 33 uM and 33 uM respectively. Inhibits the breakdown of Ala-pNA by aminopeptidase N in vitro with an IC(50) of 65 uM. Has a potent analgesic effect when administered to rats by intravenous injection. {ECO:0000269|PubMed:17101991}.
uniprot
proteins
mass_dalton
27217
uniprot
proteins
protein_family
PROL1/PROL3 family
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17101991
uniprot
proteins
pubmed
25946035
uniprot
proteins
pubmed
8670737
uniprot
proteins
sequence_length
248
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17101991}.
uniprot
proteins