Stxbp5l
entrez
207227
canonical
uniprot
Q5DQR4
canonical
ensembl
ENSMUSG00000022829
resolver
ensp
ENSMUSP00000110428
resolver
ensp
ENSMUSP00000110429
resolver
ensp
ENSMUSP00000110430
resolver
ensp
ENSMUSP00000110435
resolver
ensp
ENSMUSP00000318565
resolver
ensp
ENSMUSP00000318569
resolver
ensp
ENSMUSP00000318579
resolver
genesymbol
Stxbp5l
resolver
genesymbol_syn
Llgl4
resolver
uniprot
Q3TSM3
resolver
uniprot
Q3UVG2
resolver
uniprot
Q5DQR1
resolver
uniprot
Q5DQR2
resolver
uniprot
Q5DQR3
resolver
uniprot
Q8BS52
resolver
uniprot_entry
STB5L_MOUSE
resolver
uniprot_sec
Q3TSM3
resolver
uniprot_sec
Q3UVG2
resolver
uniprot_sec
Q5DQR1
resolver
uniprot_sec
Q5DQR2
resolver
uniprot_sec
Q5DQR3
resolver
uniprot_sec
Q8BS52
resolver
amino_acid_sequence
MKKFNFRKVLDGLTASSPGSGSSSGSNSGGAGSGSVHPGGTAGLPREEIQESLTSDYFQICKTVRHGFPYQPTALAFDPVQKILAIGTRTGAIRILGRPGVDCYCQHESGAAVLQLQFLINEGALVSASSDDTLHLWNLRQKRPAILHSLKFNRERITYCHLPFQSKWLYVGTERGNTHIVNIESFILSGYVIMWNKAIELSTKTHPGPVVHLSDSPRDEGKLLIGYENGTVVFWDLKSKRAELRVYYDEAIHSIDWHHEGKQFMCSHSDGSLTLWNLKSPSRPFQTTVPHGKSQREGRKSESCKPILKVEYKTCRNSEPFIIFSGGLSYDKACRRPSLTIMHGKAITVLEMDHPIVEFLTLCETPYPNEFQEPYAVAVLLEKDLIVVDLTQTNFPIFENPYPMDIHESPVTCTAYFADCPPDLILVLYSIGVKHKKQGYSNKEWPVSGGAWNLGAQTYPEIIITGHADGTIKFWDASAMTLQMLYKLKTSKVFEKQKAGEGKQTCELVEEDPFAVQMIYWCPESRIFCVSGVSAYVIIYKFSRHEVTTEIVSLEVRLQCDVEDIITPEPETSPPFPDLSSQLPPSRSLSGSTNTVSSEGVTKDSIPCLSVKTRPVRMPPGYQADLVIQLVWVDGEPPQQITSLSISSAYGIVAFGNCTGLVVVDFIQKTVLLSMGTIDLYRSSDLYQRQPRSPRKNRQFIADNFCMRGLSNFYPDLTKRIRTSYQSLTELNDSPVPLELERCKSPTSDHVNGHCTSPTSQSCSSGKRLSSADVSKVNRWGPGRPPFRKAQSAACMEISLPVTTEETRENSYNRSRSSSISSIDKDSKEAITALYFMESFARKNDSTVSPCLFVGTSLGMVVLISLNLPSSDEQRFTEPVVVLPSGTFLSLKGAVLTFSCMDRTGSLMQPPYEVWRDPNNTDENEKTWKRKLVMNYSSSSQEMGDHQYTIICSEKQAKVFSLPSQTCLYVHNITETSFILQADVVVMCNSACLACFCANGHIMIMSLPSLRPMLDVNYLPLTDMRIARTFCFTNEGQALYLVSPTEIQRLTYSQEMCDNIQDMLGDLFTPIETPEAQNRGFLKGLFGGSGQTFDREELFGEASAGKASRSLAQHIPGPGSIEGMKGAAGGVMGELTRARIALDERGQRLGELEEKTAGMMTSAEAFSKHAHELMLKYKDKKWYQF
uniprot
proteins
function
FUNCTION: Plays a role in vesicle trafficking and exocytosis inhibition (PubMed:25002582). In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane (PubMed:21998599). Also plays a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation (PubMed:24744148). Promotes as well axonal outgrowth (By similarity). {ECO:0000250|UniProtKB:Q9Y2K9, ECO:0000269|PubMed:21998599, ECO:0000269|PubMed:24744148, ECO:0000269|PubMed:25002582}.
uniprot
proteins
mass_dalton
131844
uniprot
proteins
post_translational_modification
PTM: Phosphorylated, leading to STXBP5L increased turnover and subsequent de-repression of insulin secretion (PubMed:25002582). Phosphorylated on serine residues in response to glucose or phorbol esters (PubMed:25002582). {ECO:0000269|PubMed:25002582}.; PTM: Ubiquitinated by the E3 ligase SYVN1, leading to STXBP5L proteasomal degradation. {ECO:0000269|PubMed:25002582}.
uniprot
proteins
protein_family
WD repeat L(2)GL family
uniprot
proteins
pubmed
15659226
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21998599
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24744148
uniprot
proteins
pubmed
25002582
uniprot
proteins
sequence_length
1185
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Cell membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Cytoplasmic, and associated with vesicular membranes and the plasma membrane. {ECO:0000305}.
uniprot
proteins