D3Z5L6
uniprot
D3Z5L6
canonical
amino_acid_sequence
MDEAGSPAPAGTGGGDDPGGSTRETSRRLSREQIFVLVSAASMNLGCMMTYSILGPFFPKEAEKKGASNTMIGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAGMFVSGGVTILFGVLDQLPEGPIFIAMCFLVRIVDAIGFGAAITASSSILAKAFPNNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLNLYILPSYAQESDPGKQSFWKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPTLRKWLLVFGNLITAGCYMLLGPVPLLHIKSQLWLLVLVLVVNGISAGMSIIPTFPEMLSCAYANGFEDSISTLGLVSGLFGAMWSVGAFMGPILGGFLCEKIGFEWAAAMQGLWTLLSGVSMALFYLWEDSTARRRSKAQNSLGTEEERAALLPNDT
uniprot
proteins
function
FUNCTION: Proton-coupled polyamine antiporter involved in the translocation of polyamines from cytosol into secretory vesicles prior to their release via exocytosis. Uses the electrochemical proton gradient generated by a V-type proton-pumping ATPase to couple the efflux of protons with the uptake of a polyamine molecule (By similarity). Facilitates vesicular storage of spermine and spermidine in astrocytes with an impact on glutamatergic neuronal transmission and memory formation (By similarity) (PubMed:31800589). Upon antigen stimulation, regulates polyamine accumulation and release in mast cell secretory granules, which in turn potentiates mast cell degranulation and histamine secretion (PubMed:28082679). {ECO:0000250|UniProtKB:D4A9K4, ECO:0000250|UniProtKB:Q6NT16, ECO:0000269|PubMed:28082679, ECO:0000269|PubMed:31800589}.
uniprot
proteins
mass_dalton
49009
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19697161
uniprot
proteins
pubmed
25355561
uniprot
proteins
pubmed
28082679
uniprot
proteins
pubmed
31800589
uniprot
proteins
sequence_length
459
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:28082679}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:D4A9K4}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with VAMP3 and VAMP8 in mast cell secretory granules, which are distinct from histamine- and serotonin-containing granules (PubMed:28082679). Partly colocalizes with SYP in synaptic vesicles in hippocampal neurons. Colocalizes with SYP and VAMP2 in secretory vesicles of astrocytes (By similarity). {ECO:0000250|UniProtKB:D4A9K4, ECO:0000269|PubMed:28082679}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..54; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 71..91; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 101..121; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 128..148; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 168..188; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 196..216; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 236..256; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 275..295; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 307..327; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 334..354; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 380..400; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 410..430; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins