Slc35d1
entrez
242585
canonical
uniprot
A2AKQ0
canonical
ensembl
ENSMUSG00000028521
resolver
ensp
ENSMUSP00000037617
resolver
ensp
ENSMUSP00000122124
resolver
genesymbol
Slc35d1
resolver
uniprot
Q3TE90
resolver
uniprot
Q5DU40
resolver
uniprot
Q8BKX2
resolver
uniprot
Q8BX24
resolver
uniprot_entry
S35D1_MOUSE
resolver
uniprot_sec
Q3TE90
resolver
uniprot_sec
Q5DU40
resolver
uniprot_sec
Q8BKX2
resolver
uniprot_sec
Q8BX24
resolver
amino_acid_sequence
MAEVHRRQHAPVKGEAPAKSSTHRDEEELGMAPAETLTVFLKLLAAGFYGVSSFLIVVVNKSVLTNYRFPSSLCVGLGQMVATVAVLWVGKTLRVVKFPDFDRNVPRKTFPLPLLYFGNQITGLFSTKKLNLPMFTVLRRFSILFTMFAEGALLKKTFSWGIKMTVFAMIIGAFVAASSDLAFDLEGYVFILINDVLTAANGAYVKQKLDSKELGKYGLLYYNALFMILPTLAIAYFTGDAQKAMEFEGWADTLFLLQFTLSCVMGFILMYATVLCTQYNSALTTTIVGCIKNILITYIGMVFGGDYIFTWTNFIGLNISIAGSLVYSYITFTEEQLSKQSEASNKLDTKGKGAV
uniprot
proteins
function
FUNCTION: Antiporter that transports nucleotide sugars across the endoplasmic reticulum (ER) membrane in exchange for either their cognate nucleoside monophosphate or another nucleotide sugar (By similarity). Transports various UDP-sugars including UDP-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc), UDP-N-acetyl-alpha-D-galactosamine (UDP-GalNAc) and UDP-alpha-D-glucuronate (UDP-GlcA), which are used by ER glucosyltransferases as sugar donors for the synthesis of sugar chains of glycoproteins, glycolipids and oligosaccharides (By similarity). May couple UDP-GlcNAc or UDP-GalNAc efflux to UDP-GlcA influx into the ER lumen that in turn stimulates glucuronidation and subsequent excretion of endobiotics and xenobiotics (By similarity). Plays a role in chondroitin sulfate biosynthesis, which is important for formation of cartilage extracellular matrix and normal skeletal development. {ECO:0000250|UniProtKB:Q9NTN3, ECO:0000269|PubMed:17952091}.
uniprot
proteins
mass_dalton
39272
uniprot
proteins
protein_family
SLC35D subfamily
uniprot
proteins
protein_family
TPT transporter family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17952091
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
355
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17952091}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 39..59; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 69..89; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 157..177; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 185..205; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 217..237; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 254..274; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 281..303; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 315..335; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins