Ncstn
entrez
289231
canonical
uniprot
Q8CGU6
canonical
ensembl
ENSRNOG00000005355
resolver
ensembl
ENSRNOG00055021437
resolver
ensembl
ENSRNOG00060019428
resolver
ensembl
ENSRNOG00065025166
resolver
ensp
ENSRNOP00000008150
resolver
ensp
ENSRNOP00000080989
resolver
enst
ENSRNOT00000109609
resolver
genesymbol
Ncstn
resolver
uniprot
A0A8I6G5D3
resolver
uniprot
A6JG20
resolver
uniprot
B3DM90
resolver
uniprot
Q8CH12
resolver
uniprot_entry
A0A8I6G5D3_RAT
resolver
uniprot_entry
B3DM90_RAT
resolver
uniprot_entry
NICA_RAT
resolver
uniprot_sec
A6JG20
resolver
uniprot_sec
Q8CH12
resolver
amino_acid_sequence
MATARGGSGPDPGSRGLLLLSFSVVLAGLCGGNSVERKIYIPLNKTAPCVRLLNATHQIGCQSSISGDTGVIHVVEKEDDLKWVLTDGPNPPYMVLLEGKLFTRDIMEKLKGETSRIAGLAVTLAKPNSTSSFSPSVQCPNDGFGIYSNSYGPEFAHCKKTLWNELGNGLAYDDFSFPIFLLEDENETKVIKQCYQDHNLGQNGSAPSFPLCAMQLFSHMHAVISTATCMRRSFIQSTFSINPEIVCDPLSDYNVWSMLKPINTSGGLEPDVRVVVAATRLDSRSFFWNVAPGAESAVASFVTQLAAAEALHKAPDVTTLPRNVMFVFFQGETFDYIGSSRMVYDMENGKFPVRLENIDSFVELGQVALRTSLELWMHTDPMSQKNESVKNQVEDLLVTLEQSGADTPQVVLSRLVQSQALPPSSLQRFLRARNISGVVLADHSGSFHNRYYQSIYDTAENINVTYPESQSPEEDLNFVTDTAKALADVATVLARALYKLAGGTNFNNSIQADPQTVTRLLYGFLVRANNSWFQSILRHDLRSYLDDGPLQHYIAVSSPTNTTYVVQYALANLTGKVTNLTQEQCQDPSKVPNESKDLYEYSWVQGPWNSNKTERLPRCVRSTVRLARALSPAFELSQWSSTEYSTWAESRWKDIQARIFLIASKELEFITLIVGFSILVFSLIVTYCINAKADVLFVAPREPGAVSY
uniprot
proteins
function
FUNCTION: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels. {ECO:0000250|UniProtKB:Q92542}.
uniprot
proteins
mass_dalton
78400
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q92542}.
uniprot
proteins
protein_family
Nicastrin family
uniprot
proteins
pubmed
24090084
uniprot
proteins
sequence_length
708
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q92542}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q92542}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q92542}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q92542}. Melanosome {ECO:0000250|UniProtKB:Q92542}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. {ECO:0000250|UniProtKB:Q92542}.
uniprot
proteins
transmembrane_region
TRANSMEM 669..689; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q92542
uniprot
proteins