Helz2
entrez
229003
canonical
uniprot
E9QAM5
canonical
ensembl
ENSMUSG00000027580
resolver
ensp
ENSMUSP00000091756
resolver
ensp
ENSMUSP00000104459
resolver
ensp
ENSMUSP00000112917
resolver
enst
ENSMUST00000094203
resolver
enst
ENSMUST00000108831
resolver
genesymbol
Helz2
resolver
genesymbol_syn
BC006779
resolver
uniprot
A2AS03
resolver
uniprot
B9A0U1
resolver
uniprot
Q3TZD5
resolver
uniprot_entry
A2AS03_MOUSE
resolver
uniprot_entry
HELZ2_MOUSE
resolver
uniprot_entry
Q3TZD5_MOUSE
resolver
uniprot_sec
B9A0U1
resolver
amino_acid_sequence
MASVGCSLRSASTSATNGPSLAGLCAKVDLYLGCSRCTQCLNESTYILREVEHTCPREILLARFKQAAESKIWRKVGRRPSFPTPMRYQVCHYYRPGLGCRRHWNRCTFARSPEEALVWTFELKNNLPRLKLKEAVQGTRAPDRLQTPADTIRAEFGGHFQLLCAICFTCCPPCLCPVDPRGHCPKHQICPTLLIHVIVEGLKRQFVEVRPLPQRRHPLNYCMYVGRGVPCRHGASRCEYAHSAVEMAVWKAEQLDGLQRGDLLTYPLFGENKWKASPNPNPPVTKLYCHACLVTCNSQEAFENHCSSLEHAQMVAFDQAVPWKHRAPPMGLSKFDLCPRPDLCEHGEVCIKAHSKQELQEWVQRAQDMELREQAAWQDGLVPYQARLLAEYQRSSKEVSVMAETIRGVSVTCHPPPVHQAQEKIQHQWVFTIHSEDPLLHVALLNQEPGAAFSLVAPSLPPHQLYAQGKHFCVQSSPAQYKVGVLVQAVAFGSFEQWVVFDFGRRPVLLQKLKLQLGQTHSQGLNGKPAPSHPQELECWHTGNRHVVLEVDWTPEQEALMAKYKLPSLALEFNQIVPDWGPISRSNYRQRMHKFLYEEEAAQQQLVAKLAMKGQVSLKTALETPALGMLFAPPGALYAKVPFHSSLLPDTDQGFLLSRAVSTALVAPVPAPNSTVYQVRLEARASSDHALWLLLPARCCMALGLQAQDSPILEVQFQIDPMTFRFWHQAVDALLEEHLVVPDLPACTLPHPWPTPPSFRGNHKQKLAVGLIAGRRPEGTKHIPPLLIYGPFGTGKTYTLAMAALEVVQQPHTKVLICTHTNSAADIYIREYFHDYVSSGHPEATPLRVMYADRPPRQTDPTTLQYCCLTEDRQAFRPPTGPELVHHRLVVTTTSQARELQVPAGFFSHIFIDEAAQMLECEALIPLSYALSLTRVVLAGDHMQVTPRLFSVPRDKSARHTLLHRLFLYYQQEAHKIAQQSRIIFHENYRSTAAIINFVSHHFYLAKGNPIQASGKVPRHPQHYPLMFCHVAGSPEQDMSMTSWLNSAEVTQVVEKVREIYNTWPHCWGPREQRHICAVSHGAQVSALRQELRRRNLGEVSVGSFEILPGREFRVVVLSSVHNRNSLLSPGAPTSEFFTEPRVLNTVMTRAQSQLVAVGDAVALCSSGACRNLWRSFIRECIEHHSAFPEELSLEQIEQGVAQRQNWASLTLKARGPETEQKSMAQGPQRLIAEGTMVTVKAETRAEAAAKAQTAAVAAEDTASGNSASRDAAAEVSTLEGGMSEEDSESDFWPSDWELNADDAILKELLDESQQVTVTVREDGLLDTVVCSAPQKAREYTNLPSSVLWKFLRSNSKQFRRCSFLQETFERALATPLDDMASSPIQVRGRLNCGMAFTGDEVLVQILGPAGDDRCVPGSLQGRVMGVLKRRRHELAFVCRMDEWDPRIMIPINGSVTKIFVAEMKDPQQVPIHRLIQGQVQRVRHETLKPEDRSTRLFWVRIVLWRERFYYPLGIVLEVLPKAITWEQGLYILDLEHGLKAHTPDPASVSKALQRYRSELNTAAGHREDYRHFLTFTVDPQGACNLDDALSVRDLGPVYEVAVHIADVASLVPKDGALDVEARQQGTVFYAPNREPVLMLPASLCQDALSLLPGQDRLAISLFLTMEKGGGQIKSLRFAPSIIRSDRQLSYEEAEELIKRHPGAGLELPAHLDSVEACVVAACYFSWMLRRQRLSAACYYEPPDEDSVLGFRTAHIMVQEYMIQFNSHVAEFLVSNKHTQTLTPLRWQPTPSRQQLDSVFKKYRGLVPLSLHLCHHSNTDYTPNKQLHLLTSLWKQVQLAAGTQDYSQMVDLIAADDMHPSLAPACLDLRRALGRSVFGRSSQGKQQPAVHHSLQVDWYTWATSPIRRYLDVVLQRLILLALGHRGSTYSNRDIDGLCLDFSRQYASAQSYQRRAYSLHLAIQLKSQPQNKLGFVVDVEMGARCFKVLFPINRETLPDPCPIHYHSLQLAEHPQELVSQTGVRLVWRRRMYSVQASKLPLPLLGTSLDPHTQTVDAALWMKLLMLLKEQRWPEIAALIQEQDKRFHPREKVKIHQSRCGHFVEVVYELGSGDTLQVQLGSSLQRGFLAPTLKLWTVVPGFSLCLEHMERPGDCFSSHVHQALQDQYLQVGEYSGAWGPRCALESLTNAVTENDSIVLHDVHISWDTSQGQLQGTFQLEAAFLQEKCINIHFGCCYLCIRLEGLPLPLDSSLPGPSGLGPFLNIDPNTYTWVAHGLSGDWDHELAGGDWDQENVDDRQEAPKQVYFLIHHMTMEKVPEEVLRPSARFTVEVLSKQLPDLRKEEAVRQLKTASPLVISIALGLPIPEIRWPISGPRRLVSELRWPIPGPRRPVSEPHRPMSGPCGPISEPCRSIPEPCRGNWPRQHSFHKASTSRFLERQNYNIPAGHHKLNQSQDRAVRSALQKQFTVIQGPPGTGKTVVGFHIVYWFHRSNQEQMPTDSSPSGEEQLGGPCVLYCGPSNKSVDVLGGLLLRRKTEMKPLRVYGEQAEATEFPLPGVSNRSLFGKTSQEGRPNQSLRSITLHHRIRQAPNPYAAEIRKFDAQLREGKIFSKEDLRVYRRVLGKARKHELERHSVILCTCSCAASKSLKILNVRQILIDEAGMATEPETLIPLVCFSKTVEKVVLLGDHKQLRPVVKSEQLQSLGMDRSLFERYHRDAIMLDTQYRMHKDICSFPSVEFYGGKLKTWSDLRRLPSILGHTGKPSCSVIFGSVQGHEQKLLVSTEDGNENSRANPEEVTQVVRIIKQLTLDRTVDPKDIAVLTPYNAQAAAISRGLMQRGVTGVTVTSITKSQGSEWRYVIVSTVRTCPRSDVDQRPTKSWLKKFLGFVVDPHQVNVAITRAQEALCIIGDHLLLRCCPLWHRLLDFCEAQHSLVSAEKVRVQRKSALSS
uniprot
proteins
ec_number
3.1.13.1
uniprot
proteins
ec_number
5.6.2.6
uniprot
proteins
function
FUNCTION: Multifunctional nuclear protein involved in RNA surveillance, nuclear receptor-mediated transcriptional regulation, and the restriction of mobile genetic elements as part of the innate immune response. Degrades highly structured RNAs through its concerted ATP-dependent RNA helicase and 3' to 5' exoribonuclease activities. Shows a strong preference for pyrimidine over purine residues for its nuclease activity. Acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA. In addition, regulates lipid metabolism independently of PPARs by controlling the stability of Apob mRNA, which encodes a protein essential for lipoprotein assembly and secretion. Also contributes to adipocyte differentiation through interactions with the splicing factor proline- and glutamine-rich protein SFPQ and THRAP3 (PubMed:23525231, PubMed:41446920). {ECO:0000250|UniProtKB:Q9BYK8, ECO:0000269|PubMed:23525231, ECO:0000269|PubMed:41446920}.
uniprot
proteins
mass_dalton
331563
uniprot
proteins
protein_family
DNA2/NAM7 helicase family
uniprot
proteins
pubmed
16239304
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23525231
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
41446920
uniprot
proteins
sequence_length
2947
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BYK8}.
uniprot
proteins