Acer1
entrez
171168
canonical
uniprot
Q8R4X1
canonical
ensembl
ENSMUSG00000045019
resolver
ensp
ENSMUSP00000062037
resolver
enst
ENSMUST00000056113
resolver
genesymbol
Acer1
resolver
genesymbol_syn
Asah3
resolver
uniprot
A1L3S2
resolver
uniprot_entry
ACER1_MOUSE
resolver
uniprot_sec
A1L3S2
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by sphingosine (PubMed:12783875). Inhibited by Mn(2+), Zn(2+), and Cu(2+) in a dose-dependent manner (PubMed:12783875). Slightly activated by Ca(2+) in a dose-dependent manner (PubMed:12783875). {ECO:0000269|PubMed:12783875}.
uniprot
proteins
amino_acid_sequence
MHVPGTRAKMSSIFAYQSSEVDWCESNFQHSELVAEFYNTFSNVFFLIFGPLMMFLMHPYAQKRTRCFYGVSVLFMLIGLFSMYFHMTLSFLGQLLDEISILWLLASGYSVWLPRCYFPKFVKGNRFYFSCLVTITTIISTFLTFVKPTVNAYALNSIAIHILYIVRTEYKKIRDDDLRHLIAVSVVLWAAALTSWISDRVLCSFWQRIHFYYLHSIWHVLISITFPYGIVTMALVDAKYEMPDKTLKVHYWPRDSWVIGLPYVEIQENDKNC
uniprot
proteins
ec_number
3.5.1.-
uniprot
proteins
ec_number
3.5.1.23
uniprot
proteins
function
FUNCTION: Endoplasmic reticulum ceramidase that catalyzes the hydrolysis of ceramides into sphingosine and free fatty acids at alkaline pH (PubMed:12783875). Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (PubMed:12783875). Exhibits a strong substrate specificity towards the natural stereoisomer of ceramides with D-erythro-sphingosine as a backbone and has a higher activity towards very long-chain unsaturated fatty acids like the C24:1-ceramide (PubMed:12783875). May also hydrolyze dihydroceramides to produce dihydrosphingosine (By similarity). ACER1 is a skin-specific ceramidase that regulates the levels of ceramides, sphingosine and sphingosine-1-phosphate in the epidermis, mediates the calcium-induced differentiation of epidermal keratinocytes and more generally plays an important role in skin homeostasis (PubMed:27126290, PubMed:29056331). {ECO:0000250|UniProtKB:Q8TDN7, ECO:0000269|PubMed:12783875, ECO:0000269|PubMed:27126290, ECO:0000269|PubMed:29056331, ECO:0000303|PubMed:12783875}.
uniprot
proteins
mass_dalton
32082
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; sphingolipid metabolism. {ECO:0000269|PubMed:12783875, ECO:0000269|PubMed:27126290}.
uniprot
proteins
protein_family
Alkaline ceramidase family
uniprot
proteins
pubmed
12783875
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
27126290
uniprot
proteins
pubmed
29056331
uniprot
proteins
sequence_length
273
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12783875}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 37..57; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 73..93; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 94..114; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 127..147; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 150..167; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 178..198; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 216..236; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins