KBTBD8
entrez
84541
canonical
uniprot
Q8NFY9
canonical
ensembl
ENSG00000163376
resolver
ensp
ENSP00000401878
resolver
genesymbol
KBTBD8
resolver
genesymbol_syn
KIAA1842
resolver
genesymbol_syn
TAKRP
resolver
hgnc
HGNC:30691
resolver
uniprot
B4DTW6
resolver
uniprot
Q96JI5
resolver
uniprot_entry
KBTB8_HUMAN
resolver
uniprot_sec
B4DTW6
resolver
uniprot_sec
Q96JI5
resolver
amino_acid_sequence
MAASADLSKSSPTPNGIPSSDPASDAMDPFHACSILKQLKTMYDEGQLTDIVVEVDHGKTFSCHRNVLAAISPYFRSMFTSGLTESTQKEVRIVGVEAESMDLVLNYAYTSRVILTEANVQALFTAASIFQIPSIQDQCAKYMISHLDPQNSIGVFIFADHYGHQELGDRSKEYIRKKFLCVTKEQEFLQLTKDQLISILDSDDLNVDREEHVYESIIRWFEHEQNEREVHLPEIFAKCIRFPLMEDTFIEKIPPQFAQAIAKSCVEKGPSNTNGCTQRLGMTASEMIICFDAAHKHSGKKQTVPCLDIVTGRVFKLCKPPNDLREVGILVSPDNDIYIAGGYRPSSSEVSIDHKAENDFWMYDHSTNRWLSKPSLLRARIGCKLVYCCGKMYAIGGRVYEGDGRNSLKSVECYDSRENCWTTVCAMPVAMEFHNAVEYKEKIYVLQGEFFLFYEPQKDYWGFLTPMTVPRIQGLAAVYKDSIYYIAGTCGNHQRMFTVEAYDIELNKWTRKKDFPCDQSINPYLKLVLFQNKLHLFVRATQVTVEEHVFRTSRKNSLYQYDDIADQWMKVYETPDRLWDLGRHFECAVAKLYPQCLQKVL
uniprot
proteins
function
FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832). {ECO:0000269|PubMed:26399832}.
uniprot
proteins
mass_dalton
68823
uniprot
proteins
mutagenesis
MUTAGEN 74; /note="Y->A: Abolishes CUL3-binding and ability to mediate monoubiquitination of NOLC1 and TCOF1."; /evidence="ECO:0000269|PubMed:26399832"; MUTAGEN 579; /note="W->A: Abolishes substrate-binding and ability to mediate monoubiquitination of NOLC1 and TCOF1."; /evidence="ECO:0000269|PubMed:26399832
uniprot
proteins
protein_family
KBTBD8 family
uniprot
proteins
pubmed
11347906
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
23578279
uniprot
proteins
pubmed
26399832
uniprot
proteins
sequence_length
601
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:23578279}. Golgi apparatus {ECO:0000269|PubMed:23578279}. Note=Translocates to the spindle apparatus during mitosis. {ECO:0000269|PubMed:23578279}.
uniprot
proteins