GEMIN7
entrez
79760
canonical
uniprot
Q9H840
canonical
ensembl
ENSG00000142252
resolver
ensp
ENSP00000270257
resolver
ensp
ENSP00000375813
resolver
ensp
ENSP00000465704
resolver
ensp
ENSP00000466342
resolver
ensp
ENSP00000555683
resolver
ensp
ENSP00000555684
resolver
ensp
ENSP00000555685
resolver
ensp
ENSP00000555686
resolver
ensp
ENSP00000555687
resolver
ensp
ENSP00000555688
resolver
ensp
ENSP00000555689
resolver
ensp
ENSP00000555690
resolver
ensp
ENSP00000555691
resolver
ensp
ENSP00000555692
resolver
ensp
ENSP00000595356
resolver
ensp
ENSP00000595357
resolver
ensp
ENSP00000595358
resolver
ensp
ENSP00000595359
resolver
ensp
ENSP00000595360
resolver
ensp
ENSP00000595361
resolver
ensp
ENSP00000595362
resolver
ensp
ENSP00000595363
resolver
ensp
ENSP00000595364
resolver
ensp
ENSP00000627049
resolver
ensp
ENSP00000627050
resolver
enst
ENST00000270257
resolver
enst
ENST00000391951
resolver
enst
ENST00000591607
resolver
enst
ENST00000591747
resolver
enst
ENST00000885624
resolver
enst
ENST00000885625
resolver
enst
ENST00000885626
resolver
enst
ENST00000885627
resolver
enst
ENST00000885628
resolver
enst
ENST00000885629
resolver
enst
ENST00000885630
resolver
enst
ENST00000885631
resolver
enst
ENST00000885632
resolver
enst
ENST00000885633
resolver
enst
ENST00000925297
resolver
enst
ENST00000925298
resolver
enst
ENST00000925299
resolver
enst
ENST00000925300
resolver
enst
ENST00000925301
resolver
enst
ENST00000925302
resolver
enst
ENST00000925303
resolver
enst
ENST00000925304
resolver
enst
ENST00000925305
resolver
enst
ENST00000956990
resolver
enst
ENST00000956991
resolver
genesymbol
GEMIN7
resolver
hgnc
HGNC:20045
resolver
uniprot
Q6IA34
resolver
uniprot_entry
GEMI7_HUMAN
resolver
uniprot_sec
Q6IA34
resolver
amino_acid_sequence
MQTPVNIPVPVLRLPRGPDGFSRGFAPDGRRAPLRPEVPEIQECPIAQESLESQEQRARAALRERYLRSLLAMVGHQVSFTLHEGVRVAAHFGATDLDVANFYVSQLQTPIGVQAEALLRCSDIISYTFKP
uniprot
proteins
function
FUNCTION: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. {ECO:0000269|PubMed:12065586, ECO:0000269|PubMed:18984161}.
uniprot
proteins
mass_dalton
14537
uniprot
proteins
protein_family
Gemin-7 family
uniprot
proteins
pubmed
12065586
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15939020
uniprot
proteins
pubmed
16314521
uniprot
proteins
pubmed
17178713
uniprot
proteins
pubmed
18984161
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
33754639
uniprot
proteins
sequence_length
131
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:12065586}. Nucleus, gem {ECO:0000269|PubMed:12065586}. Cytoplasm {ECO:0000269|PubMed:12065586}. Note=Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm.
uniprot
proteins