Prr7
entrez
432763
canonical
uniprot
Q3V0I2
canonical
ensembl
ENSMUSG00000034686
resolver
ensp
ENSMUSP00000046776
resolver
enst
ENSMUST00000046533
resolver
genesymbol
Prr7
resolver
uniprot
B2RSG4
resolver
uniprot_entry
B2RSG4_MOUSE
resolver
uniprot_entry
PRR7_MOUSE
resolver
amino_acid_sequence
MVMSQGTYTFLTCFAGFWLIWGLIVLLCCFCSFLRRRLKRRQEERLREQNLRALELEPLELEGSLAGSPPGLAPPPPPHRSRLEAPVHAHSHVHVHPLLHHGPAPPHAHPHPHHHALPHPPPPHLAVPPRPWSYPRQAESDMSKPPCYEEAVLMAEPPPPYSEVLTDTRGLYRKIVTPFLSRRDSAEKQEQPPPSYKPLFLDRGYTSALHLPSAPRPAAPCPALCLQAERSRRVFPSWTDSELSSREPLEHGAWRLPVSIPLFGRTTAV
uniprot
proteins
function
FUNCTION: Acts as a synapse-to-nucleus messenger to promote NMDA receptor-mediated excitotoxicity in neurons in a JUN-dependent manner (By similarity). Inhibits ubiquitination-mediated degradation and promotes phosphorylation and transcriptional activity of transcription factor JUN (By similarity). Might play a redundant role in the regulation of T cell receptor signaling (PubMed:27657535). Might promote apoptosis in T cells (By similarity). {ECO:0000250|UniProtKB:P0C6T3, ECO:0000250|UniProtKB:Q8TB68, ECO:0000269|PubMed:27657535}.
uniprot
proteins
mass_dalton
30354
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. {ECO:0000250|UniProtKB:Q8TB68}.; PTM: Tyrosine phosphorylated, possibly by SRC. {ECO:0000250|UniProtKB:Q8TB68}.
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27458189
uniprot
proteins
pubmed
27657535
uniprot
proteins
sequence_length
269
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8TB68}; Single-pass type III membrane protein {ECO:0000305}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P0C6T3}; Single-pass type III membrane protein {ECO:0000305}. Postsynaptic density membrane {ECO:0000250|UniProtKB:P0C6T3}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8TB68}. Synapse {ECO:0000250|UniProtKB:P0C6T3}. Cell projection, dendrite {ECO:0000250|UniProtKB:P0C6T3}. Nucleus {ECO:0000250|UniProtKB:P0C6T3}. Note=Enriched in postsynaptic plasma membrane and postsynaptic densities (PSD). Accumulates in spines along with synapse maturation and colocalizes with DLG4 in a punctate pattern. Translocates from synapses to nuclei following NMDA receptor activity (By similarity). {ECO:0000250|UniProtKB:P0C6T3}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..30; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins