Slc4a1
entrez
24779
canonical
uniprot
P23562
canonical
ensembl
ENSRNOG00000020951
resolver
ensp
ENSRNOP00000028445
resolver
ensp
ENSRNOP00000074568
resolver
genesymbol
Slc4a1
resolver
genesymbol_syn
Ae1
resolver
uniprot
Q5U329
resolver
uniprot_entry
B3AT_RAT
resolver
uniprot_entry
Q5U329_RAT
resolver
amino_acid_sequence
MGDMQDHEKVLEIPDRDSEEELEHVIEQIAYRDLDIPVTEMQESEALPTEQTATDYIPTSTSTSHPSSSQVYVELQELMMDQRNQELQWVEAAHWIGLEENLREDGVWGRPHLSYLTFWSLLELQKVFSKGTFLLDLAETSLAGVANKLLDSFIYEDQIRPQDRDELLRALLLKRSHAEDLKDLEGVKPAVLTRSGAPSEPLLPHQPSLETKLYCAQAEGGSEEPSPSGILKIPPNSETTLVLVGRASFLVKPVLGFVRLKEAVPLEDLVLPEPVSFLLVLLGPEAPHIDYTQLGRAAATLMTERVFRVTASLAQSRGELLSSLDSFLDCSLVLPPTEAPSEKALLNLVPVQKELLRKRYLPRPAKPDPNLYEALDGGKEGPGDEDDPLRRTGRIFGGLIRDIRRRYPYYLSDITDALSPQVLAAVIFIYFAALSPAVTFGGLLGEKTRNLMGVSELLISTAVQGILFALLGAQPLLVLGFSGPLLVFEEAFYSFCESNNLEYIVGRAWIGFWLILLVVLVVAFEGSFLVQYISRYTQEIFSFLISLIFIYETFSKLIKIFQDYPLQESYAPVVMKPKPQGPVPNTALLSLVLMVGTFLLAMMLRKFKNSTYFPGKLRRVIGDFGVPISILIMVLVDTFIKNTYTQKLSVPDGLKVSNSSARGWVIHPLGLYNHFPKWMMFASVLPALLVFILIFLESQITTLIVSKPERKMIKGSGFHLDLLLVVGMGGVAALFGMPWLSATTVRSVTHANALTVMGKASGPGAAAQIQEVKEQRISGLLVSVLVGLSILMEPILSRIPLAVLFGIFLYMGITSLSGIQLFDRILLLFKPPKYHPDVPFVKRVKTWRMHLFTGIQIICLAVLWVVKSTPASLALPFVLILTVPLRRLLLPLIFRELELQCLDGDDAKVTFDEAEGLDEYDEVPMPV
uniprot
proteins
function
FUNCTION: Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Component of the ankyrin-1 complex of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine. {ECO:0000250|UniProtKB:P02730}.
uniprot
proteins
mass_dalton
103173
uniprot
proteins
protein_family
Anion exchanger (TC 2.A.31) family
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2722777
uniprot
proteins
pubmed
8456965
uniprot
proteins
sequence_length
927
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P02730}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P02730}. Basolateral cell membrane {ECO:0000250|UniProtKB:P02730}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P02730}. Note=Detected in the erythrocyte cell membrane and on the basolateral membrane of alpha-intercalated cells in the collecting duct in the kidney. {ECO:0000250|UniProtKB:P02730}.
uniprot
proteins
transmembrane_region
TRANSMEM 421..444; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P02730"; TRANSMEM 453..473; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P02730"; TRANSMEM 477..493; /note="Discontinuously helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P02730"; TRANSMEM 503..523; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P02730"; TRANSMEM 536..558; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P02730"; TRANSMEM 587..607; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P02730"; TRANSMEM 619..639; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P02730"; TRANSMEM 680..700; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P02730"; TRANSMEM 717..735; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:P02730"; TRANSMEM 736..753; /note="Discontinuously helical; Name=10"; /evidence="ECO:0000250|UniProtKB:P02730"; TRANSMEM 777..797; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:P02730"; TRANSMEM 798..816; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:P02730
uniprot
proteins