F1LM93
uniprot
F1LM93
canonical
amino_acid_sequence
MGCIKSKENKSPAIKYTPENPTEPVNTSAGHYGVEHATAATTSSTKGASANFNSLSMTPFGGSSGVTPFGGASSSFSVVPSSYPTSLTGGVTIFVALYDYEARTTEDLSFKKGERFQIINNTEGDWWEARSIATGKNGYIPSNYVAPADSIQAEEWYFGKMGRKDAERLLLNPGNQRGIFLVRESETTKGAYSLSIRDWDEVRGDNVKHYKIRKLDNGGYYITTRAQFDTLQKLVKHYTEHADGLCHKLTTVCPTVKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTKVAIKTLKPGTMMPEAFLQEAQIMKKLRHDKLVPLYAVVSEEPIYIVTEFMSKGILLDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLVCKIADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPESLHELMNLCWKKDPDERPTFEYIQSFLEDYFTATEPQYQPGENL
uniprot
proteins
ec_number
2.7.10.2
uniprot
proteins
function
FUNCTION: Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGFR, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis (By similarity). Catalyzes phosphorylation of organic cation transporter OCT2 which induces its transport activity (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P07947, ECO:0000269|PubMed:21256972}.
uniprot
proteins
mass_dalton
60614
uniprot
proteins
post_translational_modification
PTM: Phosphorylated (By similarity). Phosphorylation by CSK on the C-terminal tail maintains the enzyme in an inactive state (By similarity). Autophosphorylation at Tyr-424 maintains enzyme activity by blocking CSK-mediated inhibition (By similarity). {ECO:0000250|UniProtKB:P07947, ECO:0000250|UniProtKB:Q28923}.; PTM: Palmitoylation at Cys-3 promotes membrane localization. {ECO:0000250}.
uniprot
proteins
pubmed
12640114
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
1709169
uniprot
proteins
pubmed
21256972
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
541
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1709169}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytosol {ECO:0000269|PubMed:1709169}. Cell junction {ECO:0000250|UniProtKB:Q28923}. Note=Newly synthesized protein initially accumulates in the Golgi region and traffics to the plasma membrane through the exocytic pathway. Localized to small puncta throughout the cytoplasm and cell membrane when in the presence of SNAIL1 (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q28923}.
uniprot
proteins