Mark2
entrez
60328
canonical
uniprot
O08679
canonical
ensembl
ENSRNOG00000021184
resolver
ensp
ENSRNOP00000028763
resolver
ensp
ENSRNOP00000073980
resolver
ensp
ENSRNOP00000076876
resolver
ensp
ENSRNOP00000077495
resolver
ensp
ENSRNOP00000081955
resolver
ensp
ENSRNOP00000091631
resolver
ensp
ENSRNOP00000092104
resolver
ensp
ENSRNOP00000112253
resolver
enst
ENSRNOT00000028763
resolver
enst
ENSRNOT00000094288
resolver
enst
ENSRNOT00000102315
resolver
enst
ENSRNOT00000110931
resolver
enst
ENSRNOT00000111902
resolver
enst
ENSRNOT00000161587
resolver
genesymbol
Mark2
resolver
uniprot
A0A8I5Y7M0
resolver
uniprot
A0A8I5ZU08
resolver
uniprot
A0A8I6AC19
resolver
uniprot
A0A8I6GJH6
resolver
uniprot
A0A8L2UKM6
resolver
uniprot
A0ABK0LMM5
resolver
uniprot_entry
A0A8I5Y7M0_RAT
resolver
uniprot_entry
A0A8I5ZU08_RAT
resolver
uniprot_entry
A0A8I6AC19_RAT
resolver
uniprot_entry
A0A8I6GJH6_RAT
resolver
uniprot_entry
A0A8L2UKM6_RAT
resolver
uniprot_entry
A0ABK0LMM5_RAT
resolver
uniprot_entry
MARK2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by hymenialdisine (By similarity). Activated by phosphorylation on Thr-208 by STK11/LKB1 and TAOK1. Inhibited by phosphorylation at Ser-212 or Thr-539. Inhibited by PAK5; inhibition is independent of the kinase activity of PAK5. {ECO:0000250, ECO:0000269|PubMed:14517247}.
uniprot
proteins
amino_acid_sequence
MSSARTPLPTLNERDTEQPTLGHLDSKPSSKSNMLRGRNSATSADEQPHIGNYRLLKTIGKGNFAKVKLARHILTGKEVAVKIIDKTQLNSSSLQKLFREVRIMKVLNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKFIVHRDLKAENLLLDADMNIKIADFGFSNEFTFGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLILNPSKRGTLEQIMKDRWMNVGHEDDELKPYVEPLPDYKDPRRTELMVSMGYTREEIQDSLVGQRYNEVMATYLLLGYKSSELEGDTITLKPRPSADLTNSSAPSPSHKVQRSVSANPKQRRSSDQAVPAIPTSNSYSKKTQSNNAENKRPEEETGRKASSTAKVPASPLPGLDRKKTTPTPSTNSVLSTSTNRSRNSPLLDRASLGQASIQNGKDSTAPQRVPVASPSAHNISSSSGAPDRTNFPRGVSSRSTFHAGQLRQVRDQQNLPFGVTPASPSGHSQGRRGASGSIFSKFTSKFVRRNLNEPESKDRVETLRPHVVGGGGTDKEKEEFREAKPRSLRFTWSMKTTSSMEPNEMMREIRKVLDANSCQSELHERYMLLCVHGTPGHENFVQWEMEVCKLPRLSLNGVRFKRISGTSMAFKNIASKIANELKL
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
ec_number
2.7.11.26
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates CRTC2/TORC2, DCX, HDAC7, KIF13B, MAP2, MAP4 and RAB11FIP2. Phosphorylates the microtubule-associated protein MAPT/TAU. Plays a key role in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Regulates epithelial cell polarity by phosphorylating RAB11FIP2. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Regulates axogenesis by phosphorylating KIF13B, promoting interaction between KIF13B and 14-3-3 and inhibiting microtubule-dependent accumulation of KIF13B. Also required for neurite outgrowth and establishment of neuronal polarity. Regulates localization and activity of some histone deacetylases by mediating phosphorylation of HDAC7, promoting subsequent interaction between HDAC7 and 14-3-3 and export from the nucleus. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of disheveled proteins (DVL1, DVL2 and/or DVL3). Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells. Phosphorylates UBAC2 at 'Ser-223' during ER stress or starvation-induced autophagy, promoting UBAC2 dimerization and interaction with GABARAP to mediate ER-phagy (By similarity). {ECO:0000250|UniProtKB:Q7KZI7, ECO:0000269|PubMed:14517247, ECO:0000269|PubMed:14741102, ECO:0000269|PubMed:15466480, ECO:0000269|PubMed:16717194, ECO:0000269|PubMed:18509032}.
uniprot
proteins
mass_dalton
80872
uniprot
proteins
mutagenesis
MUTAGEN 82; /note="K->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:17442826"; MUTAGEN 91..93; /note="SSS->AAA: Loss of phosphorylation by CaMK1, decrease in kinase activity and ability to promote neurite outgrowth; when associated with A-294."; /evidence="ECO:0000269|PubMed:17442826"; MUTAGEN 208; /note="T->A: Abolishes activation of serine/threonine-protein kinase activity and only basal activity remains."; /evidence="ECO:0000269|PubMed:14517247, ECO:0000269|PubMed:16257959, ECO:0000269|PubMed:18424437"; MUTAGEN 208; /note="T->E: Phosphomimetic mutant that leads to activation but not in presence of GSK3-beta."; /evidence="ECO:0000269|PubMed:14517247, ECO:0000269|PubMed:16257959, ECO:0000269|PubMed:18424437"; MUTAGEN 212; /note="S->A: Loss of activity; neither activated by TAOK1 nor by STK11/LKB1."; /evidence="ECO:0000269|PubMed:14517247, ECO:0000269|PubMed:16257959, ECO:0000269|PubMed:18424437"; MUTAGEN 294; /note="T->A: Loss of phosphorylation by CaMK1, decrease in kinase activity and ability to promote neurite outgrowth; when associated with 91-A--A-93."; /evidence="ECO:0000269|PubMed:17442826"; MUTAGEN 539; /note="T->A: Abolishes phosphorylation by PKC/PRKCZ."; /evidence="ECO:0000269|PubMed:16717194
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. Phosphorylated at Thr-208 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-208 by TAOK1 activates the kinase activity, leading to phosphorylation and detachment of MAPT/TAU from microtubules. Phosphorylation at Ser-212 by GSK3-beta (GSK3B) inhibits the kinase activity. Phosphorylation by CaMK1 promotes activity and is required to promote neurite outgrowth. Phosphorylation at Thr-539 by PRKCZ/aPKC in polarized epithelial cells inhibits the kinase activity and promotes binding to 14-3-3 protein YWHAZ, leading to relocation from cell membrane to cytoplasm. {ECO:0000269|PubMed:14517247, ECO:0000269|PubMed:16257959, ECO:0000269|PubMed:16717194, ECO:0000269|PubMed:17442826, ECO:0000269|PubMed:18424437}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
SNF1 subfamily
uniprot
proteins
pubmed
14517247
uniprot
proteins
pubmed
14741102
uniprot
proteins
pubmed
15466480
uniprot
proteins
pubmed
16014608
uniprot
proteins
pubmed
16257959
uniprot
proteins
pubmed
16472737
uniprot
proteins
pubmed
16717194
uniprot
proteins
pubmed
17442826
uniprot
proteins
pubmed
18424437
uniprot
proteins
pubmed
18509032
uniprot
proteins
pubmed
20071654
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9108484
uniprot
proteins
sequence_length
722
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14741102}; Peripheral membrane protein {ECO:0000269|PubMed:14741102}. Lateral cell membrane {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm {ECO:0000250|UniProtKB:Q7KZI7}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q7KZI7}. Note=Phosphorylation at Thr-539 by PRKCZ/aPKC and subsequent interaction with 14-3-3 protein YWHAZ promotes relocation from the cell membrane to the cytoplasm. {ECO:0000250}.
uniprot
proteins