F12
entrez
58992
canonical
uniprot
Q80YC5
canonical
ensembl
ENSMUSG00000021492
resolver
ensp
ENSMUSP00000021948
resolver
enst
ENSMUST00000021948
resolver
genesymbol
F12
resolver
uniprot
O35727
resolver
uniprot
Q6PER0
resolver
uniprot_entry
FA12_MOUSE
resolver
uniprot_sec
O35727
resolver
uniprot_sec
Q6PER0
resolver
activity_regulation
ACTIVITY REGULATION: Activity is promoted in the presence of negatively charged surfaces. {ECO:0000250|UniProtKB:P00748}.
uniprot
proteins
amino_acid_sequence
MTALLFLGSLLMSLDLTLSAPPWKDSKKFKDAPDGPTVVLTVDGRLCHFPFQYHRQLHHKCIHKRRPGSRPWCATTPNFDEDQQWGYCLEPKKVKDHCSKHNPCHKGGTCINTPNGPHCLCPEHLTGKHCQKEKCFEPQLLKFFHENELWFRTGPGGVARCECKGSEAHCKPVASQACSINPCLNGGSCLLVEDHPLCRCPTGYTGYFCDLDLWATCYEGRGLSYRGQAGTTQSGAPCQRWTVEATYRNMTEKQALSWGLGHHAFCRNPDNDTRPWCFVWSGDRLSWDYCGLEQCQTPTFAPLVVPESQEESPSQAPSLSHAPNDSTDHQTSLSKTNTMGCGQRFRKGLSSFMRVVGGLVALPGSHPYIAALYWGNNFCAGSLIAPCWVLTAAHCLQNRPAPEELTVVLGQDRHNQSCEWCQTLAVRSYRLHEGFSSITYQHDLALLRLQESKTNSCAILSPHVQPVCLPSGAAPPSETVLCEVAGWGHQFEGAEEYSTFLQEAQVPFIALDRCSNSNVHGDAILPGMLCAGFLEGGTDACQGDSGGPLVCEEGTAEHQLTLRGVISWGSGCGDRNKPGVYTDVANYLAWIQKHIAS
uniprot
proteins
ec_number
3.4.21.38
uniprot
proteins
function
FUNCTION: Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa (By similarity). {ECO:0000250|UniProtKB:P00748}.
uniprot
proteins
mass_dalton
65701
uniprot
proteins
post_translational_modification
PTM: O- and N-glycosylated. {ECO:0000250}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
597
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
uniprot
proteins