Nherf4
entrez
170761
canonical
uniprot
Q99MJ6
canonical
ensembl
ENSMUSG00000032105
resolver
ensp
ENSMUSP00000034618
resolver
enst
ENSMUST00000034618
resolver
genesymbol
Nherf4
resolver
genesymbol_syn
Pdzd3
resolver
genesymbol_syn
Pdzk2
resolver
uniprot
A0A0R4J0D4
resolver
uniprot
Q8BWE5
resolver
uniprot_entry
A0A0R4J0D4_MOUSE
resolver
uniprot_entry
NHRF4_MOUSE
resolver
uniprot_sec
Q8BWE5
resolver
amino_acid_sequence
MEAAADLRDTALLTLKFKFNPRLGIDNPVLSLAEDQDQSDPWNLHRPRFCLLSKEEEKTFGFHLQQHLGKADHVVCRVDPGTSAQRQGLREGDRILAVNNNIVAHEDHAVVVRYIRASGPRVLLTVLAQHVHDVARVLQGSDAFLCPTLPSGVRPRLCHVVKDEGGFGFSVTHGSRGPFWLVLSAGGAAERAGVPPGARLLEVNGASVEKLTYNQLNRKLWQSGDQVTLLVAGLEVEEQCHQLGMPLAAPLAEGWALPAKPRCLNIEKGPEGFGFLLREEKGLDGRLGQFLWDVDPGLPADKAGMKAGDRLVAVAGESVDGLGHEETVSRIRAQGSCVSLIVVDPEADRFFSMVRLSPLLFLENTEIAAPPLAETKDLPVEDTVEPSGLAGSCQCFLYPGPGGGYGFRLCCVASGPCLFISQVTPGGSTARAGLQVGDTVLEVNGYPVGGDSELDRLQQLTEAEPPLCLKLGARNPQGLEAWISLESGEDWTLASELL
uniprot
proteins
function
FUNCTION: Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (By similarity). Stimulates SLC9A3 activity in the presence of elevated calcium ions (By similarity). {ECO:0000250|UniProtKB:Q86UT5}.
uniprot
proteins
mass_dalton
53525
uniprot
proteins
mutagenesis
MUTAGEN 329; /note="S->A: Loss of phosphorylation. Significant increase in interaction with SLC26A3."; /evidence="ECO:0000269|PubMed:22627094"; MUTAGEN 329; /note="S->D: Phosphomimetic mutant. Significant decrease in interaction with SLC26A3."; /evidence="ECO:0000269|PubMed:22627094
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-329 negatively regulates its interaction with SLC26A3. {ECO:0000269|PubMed:22627094}.
uniprot
proteins
pubmed
11099500
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19088451
uniprot
proteins
pubmed
22627094
uniprot
proteins
pubmed
26756164
uniprot
proteins
sequence_length
498
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26756164}; Peripheral membrane protein {ECO:0000305|PubMed:26756164}. Cytoplasm {ECO:0000269|PubMed:26756164}. Note=In kidney, predominantly localized to the subapical compartment of proximal tubular cells (PubMed:11099500). In intestinal epithelial cells, localizes to the ileal brush border and in a juxtanuclear compartment (PubMed:19088451). Expressed in the membrane, with relatively low expression in the cytoplasm (PubMed:26756164). {ECO:0000269|PubMed:11099500, ECO:0000269|PubMed:19088451, ECO:0000269|PubMed:26756164}.
uniprot
proteins