Masp1
entrez
64023
canonical
uniprot
Q8CHN8
canonical
ensembl
ENSRNOG00000001827
resolver
ensembl
ENSRNOG00055004619
resolver
ensembl
ENSRNOG00060013056
resolver
ensembl
ENSRNOG00065003514
resolver
ensp
ENSRNOP00000044812
resolver
ensp
ENSRNOP00000078578
resolver
ensp
ENSRNOP00000079792
resolver
genesymbol
Masp1
resolver
genesymbol_syn
Crarf
resolver
uniprot
O09020
resolver
uniprot
Q5U365
resolver
uniprot
Q8CG41
resolver
uniprot
Q9JJS9
resolver
uniprot_entry
MASP1_RAT
resolver
uniprot_sec
O09020
resolver
uniprot_sec
Q5U365
resolver
uniprot_sec
Q8CG41
resolver
uniprot_sec
Q9JJS9
resolver
amino_acid_sequence
MRFLSFRRLLLYHVLCLTLTEVSAHTVELNEMFGQIQSPGYPDSYPSDSEVTWNITVPEGFRVQLYFMHFNLESSYLCEYDYVKVETEDQVLATFCGRETTDTEQTPGQEVVLSPGSFMSVTFRSDFSNEERFTGFDAHYMAVDVDECKEREDEELSCDHYCHNYIGGYYCSCRFGYILHTDNRTCRVECSGNLFTQRTGTITSPDYPNPYPKSSECSYTIDLEEGFMVTLQFEDIFDIEDHPEVPCPYDYIKIKAGSKVWGPFCGEKSPEPISTQSHSIQILFRSDNSGENRGWRLSYRAAGNECPKLQPPVYGKIEPSQAVYSFKDQVLISCDTGYKVLKDNEVMDTFQIECLKDGAWSNKIPTCKIVDCGVPAVLKHGLVTFSTRNNLTTYKSEIRYSCQQPYYKMLHNTTGVYTCSAHGTWTNEVLKRSLPTCLPVCGLPKFSRKHISRIFNGRPAQKGTTPWIAMLSQLNGQPFCGGSLLGSNWVLTAAHCLHHPLDPEEPILHNSHLLSPSDFKIIMGKHWRRRSDEDEQHLHVKHIMLHPLYNPSTFENDLGLVELSESPRLNDFVMPVCLPEHPSTEGTMVIVSGWGKQFLQRLPENLMEIEIPIVNYHTCQEAYTPLGKKVTQDMICAGEKEGGKDACAGDSGGPMVTKDAERDQWYLVGVVSWGEDCGKKDRYGVYSYIYPNKDWIQRVTGVRN
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Precursor of a serum protease that activates the complement pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. {ECO:0000269|PubMed:15060079}.; FUNCTION: [Isoform MASP-1]: Serine protease that activates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The lectin complement system is activated following association of lectins, such as MBL2, FCN1, FCN2 or FCN3, to carbohydrates on the pathogen surface. Following autoproteolytic processing in response to lectin-binding to pathogen carbohydrates, catalyzes cleavage and activation of MASP2, the next component of the lectin complement pathway. {ECO:0000250|UniProtKB:P48740}.; FUNCTION: [Isoform MASP-3]: Serine protease that activates the alternative pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The alternative complement pathway acts as an amplification loop that enhances other complement pathways. Isoform MASP-3 specifically catalyzes cleavage and activation of factor D (CFD), the protease that initiates the alternative complement pathway. {ECO:0000250|UniProtKB:P48740}.
uniprot
proteins
mass_dalton
80097
uniprot
proteins
mutagenesis
MUTAGEN 651; /note="S->A: Prevents protease self-activation through proteolytic cleavage into heavy and light chain."; /evidence="ECO:0000269|PubMed:11337510
uniprot
proteins
post_translational_modification
PTM: [Isoform MASP-1]: Autoproteolytic processing of the proenzyme produces the active enzyme composed on the heavy and the light chain held together by a disulfide bond. {ECO:0000250|UniProtKB:P48740}.; PTM: [Isoform MASP-3]: In contrast to isoform MASP-1, not activated through autoproteolytic processing. {ECO:0000250|UniProtKB:P48740}.; PTM: N-glycosylated. Some N-linked glycan are of the complex-type. {ECO:0000269|PubMed:10913141}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
10913141
uniprot
proteins
pubmed
11337510
uniprot
proteins
pubmed
12847554
uniprot
proteins
pubmed
15060079
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22078562
uniprot
proteins
pubmed
28111019
uniprot
proteins
pubmed
9314946
uniprot
proteins
sequence_length
704
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12847554}.; SUBCELLULAR LOCATION: [Isoform MASP-1]: Secreted {ECO:0000250|UniProtKB:P48740}. Cell surface {ECO:0000250|UniProtKB:P48740}. Note=Recruited to the surface of pathogens by the mannose-binding proteins, such as MBL2. {ECO:0000250|UniProtKB:P48740}.; SUBCELLULAR LOCATION: [Isoform MASP-3]: Secreted {ECO:0000250|UniProtKB:P48740}.
uniprot
proteins