EPHB6
entrez
2051
canonical
uniprot
O15197
canonical
ensembl
ENSG00000106123
resolver
ensembl
ENSG00000275482
resolver
ensp
ENSP00000404786
resolver
ensp
ENSP00000481418
resolver
ensp
ENSP00000481994
resolver
ensp
ENSP00000487627
resolver
ensp
ENSP00000498670
resolver
ensp
ENSP00000556706
resolver
ensp
ENSP00000556709
resolver
ensp
ENSP00000556712
resolver
ensp
ENSP00000607348
resolver
ensp
ENSP00000607350
resolver
ensp
ENSP00000607351
resolver
ensp
ENSP00000611037
resolver
enst
ENST00000422643
resolver
enst
ENST00000618483
resolver
enst
ENST00000619012
resolver
enst
ENST00000632037
resolver
enst
ENST00000652003
resolver
enst
ENST00000937289
resolver
enst
ENST00000937291
resolver
enst
ENST00000937292
resolver
enst
ENST00000940978
resolver
genesymbol
EPHB6
resolver
hgnc
HGNC:3396
resolver
uniprot
A0A0G2JNH7
resolver
uniprot
A4D2I7
resolver
uniprot
A8CDT5
resolver
uniprot
D3DXD3
resolver
uniprot
F8WCM8
resolver
uniprot
Q2TB23
resolver
uniprot
Q2TB24
resolver
uniprot_entry
A0A0G2JNH7_HUMAN
resolver
uniprot_entry
EPHB6_HUMAN
resolver
uniprot_entry
F8WCM8_HUMAN
resolver
uniprot_sec
A4D2I7
resolver
uniprot_sec
A8CDT5
resolver
uniprot_sec
D3DXD3
resolver
uniprot_sec
Q2TB23
resolver
uniprot_sec
Q2TB24
resolver
amino_acid_sequence
MATEGAAQLGNRVAGMVCSLWVLLLVSSVLALEEVLLDTTGETSEIGWLTYPPGGWDEVSVLDDQRRLTRTFEACHVAGAPPGTGQDNWLQTHFVERRGAQRAHIRLHFSVRACSSLGVSGGTCRETFTLYYRQAEEPDSPDSVSSWHLKRWTKVDTIAADESFPSSSSSSSSSSSAAWAVGPHGAGQRAGLQLNVKERSFGPLTQRGFYVAFQDTGACLALVAVRLFSYTCPAVLRSFASFPETQASGAGGASLVAAVGTCVAHAEPEEDGVGGQAGGSPPRLHCNGEGKWMVAVGGCRCQPGYQPARGDKACQACPRGLYKSSAGNAPCSPCPARSHAPNPAAPVCPCLEGFYRASSDPPEAPCTGPPSAPQELWFEVQGSALMLHWRLPRELGGRGDLLFNVVCKECEGRQEPASGGGGTCHRCRDEVHFDPRQRGLTESRVLVGGLRAHVPYILEVQAVNGVSELSPDPPQAAAINVSTSHEVPSAVPVVHQVSRASNSITVSWPQPDQTNGNILDYQLRYYDQAEDESHSFTLTSETNTATVTQLSPGHIYGFQVRARTAAGHGPYGGKVYFQTLPQGELSSQLPERLSLVIGSILGALAFLLLAAITVLAVVFQRKRRGTGYTEQLQQYSSPGLGVKYYIDPSTYEDPCQAIRELAREVDPAYIKIEEVIGTGSFGEVRQGRLQPRGRREQTVAIQALWAGGAESLQMTFLGRAAVLGQFQHPNILRLEGVVTKSRPLMVLTEFMELGPLDSFLRQREGQFSSLQLVAMQRGVAAAMQYLSSFAFVHRSLSAHSVLVNSHLVCKVARLGHSPQGPSCLLRWAAPEVIAHGKHTTSSDVWSFGILMWEVMSYGERPYWDMSEQEVLNAIEQEFRLPPPPGCPPGLHLLMLDTWQKDRARRPHFDQLVAAFDKMIRKPDTLQAGGDPGERPSQALLTPVALDFPCLDSPQAWLSAIGLECYQDNFSKFGLCTFSDVAQLSLEDLPALGITLAGHQKKLLHHIQLLQQHLRQQGSVEV
uniprot
proteins
function
FUNCTION: Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2 (PubMed:12517763, PubMed:15955811). Can recruit SH2 domain-containing signaling adapters following phosphorylation by EPHB4 (PubMed:34431498). {ECO:0000269|PubMed:12517763, ECO:0000269|PubMed:15955811, ECO:0000269|PubMed:34431498}.
uniprot
proteins
mass_dalton
110700
uniprot
proteins
mutagenesis
MUTAGEN 645; /note="Y->F: Reduces phosphorylation; when associated with F-651."; /evidence="ECO:0000269|PubMed:34431498"; MUTAGEN 651; /note="Y->F: Reduces phosphorylation; when associated with F-645."; /evidence="ECO:0000269|PubMed:34431498
uniprot
proteins
post_translational_modification
PTM: Ligand-binding increases phosphorylation on tyrosine residues. Phosphorylation on tyrosine residues is mediated by transphosphorylation by the catalytically active EPHB1 in a ligand-independent manner. Tyrosine phosphorylation of the receptor may act as a switch on the functional transition from cell adhesion/attraction to de-adhesion/repulsion (PubMed:11713248, PubMed:15955811). Also phosphorylated by EPHB4 which promotes binding of EPHB6 to SH2 domains, allowing it to interact with downstream SH2 domain-containing signaling adapters (PubMed:34431498). {ECO:0000269|PubMed:11713248, ECO:0000269|PubMed:15955811, ECO:0000269|PubMed:34431498}.
uniprot
proteins
protein_family
Ephrin receptor subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
11713248
uniprot
proteins
pubmed
12517763
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15955811
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18425388
uniprot
proteins
pubmed
18754880
uniprot
proteins
pubmed
19234485
uniprot
proteins
pubmed
34431498
uniprot
proteins
pubmed
9207182
uniprot
proteins
sequence_length
1021
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 595..615; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins