MAL2
entrez
114569
canonical
uniprot
Q969L2
canonical
ensembl
ENSG00000147676
resolver
ensp
ENSP00000479708
resolver
ensp
ENSP00000554461
resolver
ensp
ENSP00000554462
resolver
enst
ENST00000614891
resolver
enst
ENST00000884403
resolver
genesymbol
MAL2
resolver
hgnc
HGNC:13634
resolver
uniprot
B2R520
resolver
uniprot
Q6ZMD9
resolver
uniprot_entry
MAL2_HUMAN
resolver
uniprot_sec
B2R520
resolver
uniprot_sec
Q6ZMD9
resolver
amino_acid_sequence
MSAGGASVPPPPNPAVSFPPPRVTLPAGPDILRTYSGAFVCLEILFGGLVWILVASSNVPLPLLQGWVMFVSVTAFFFSLLFLGMFLSGMVAQIDANWNFLDFAYHFTVFVFYFGAFLLEAAATSLHDLHCNTTITGQPLLSDNQYNINVAASIFAFMTTACYGCSLGLALRRWRP
uniprot
proteins
function
FUNCTION: Member of the machinery of polarized transport. Required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway. {ECO:0000269|PubMed:12370246}.
uniprot
proteins
mass_dalton
19125
uniprot
proteins
protein_family
MAL family
uniprot
proteins
pubmed
11549320
uniprot
proteins
pubmed
12370246
uniprot
proteins
pubmed
14576188
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19159218
uniprot
proteins
sequence_length
176
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Endomembrane system. Cytoplasm, perinuclear region. Note=Associated with lipid rafts. In polarized epithelial cells, restricted to the apical surface. In hepatocytes, as well as in polarized hepatoma Hep-G2 cells, found in the canalicular membrane, equivalent to the apical surface, beneath the canalicular actin cytoskeleton. In non-polarized Hep-G2 cells, distributed to the perinuclear region.
uniprot
proteins
transmembrane_region
TRANSMEM 35..55; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 67..87; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 103..123; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 150..170; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins