Bmp8b
entrez
12164
canonical
uniprot
P55105
canonical
ensembl
ENSMUSG00000002384
resolver
ensp
ENSMUSP00000002457
resolver
enst
ENSMUST00000002457
resolver
genesymbol
Bmp8b
resolver
uniprot
Q8BNM2
resolver
uniprot_entry
BMP8B_MOUSE
resolver
uniprot_sec
Q8BNM2
resolver
amino_acid_sequence
MAARPGLLWLLGLALCVLGGGHLSHPPHVFPQRRLGVREPRDMQREIREVLGLPGRPRSRAPVGAAQQPASAPLFMLDLYRAMTDDSGGGTPQPHLDRADLIMSFVNIVERDRTLGYQEPHWKEFHFDLTQIPAGEAVTAAEFRIYKEPSTHPLNTTLHISMFEVVQEHSNRESDLFFLDLQTLRSGDEGWLVLDITAASDRWLLNHHKDLGLRLYVETEDGHSIDPGLAGLLGRQAPRSRQPFMVGFFRANQSPVRAPRTARPLKKKQLNQINQLPHSNKHLGILDDGHGSHGREVCRRHELYVSFRDLGWLDSVIAPQGYSAYYCAGECIYPLNSCMNSTNHATMQALVHLMKPDIIPKVCCVPTELSAISLLYYDRNNNVILRRERNMVVQACGCH
uniprot
proteins
function
FUNCTION: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis (By similarity). Involved in the generation of primordial germ cells; this function involves Bmp4 in a synergistic manner though separate receptor complexes seem to be involved. Required for the initiation and maintenance of spermatogenesis. Signaling protein involved in regulation of thermogenesis and energy balance. Proposed to increase the peripheral response of brown adipose tissue (BAT) to adrenergic stimulation while acting centrally in the hypothalamus to increase sympathetic output to BAT. {ECO:0000250, ECO:0000269|PubMed:10894154, ECO:0000269|PubMed:11427739, ECO:0000269|PubMed:22579288, ECO:0000269|PubMed:8682296}.
uniprot
proteins
mass_dalton
44943
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
10894154
uniprot
proteins
pubmed
11427739
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
22579288
uniprot
proteins
pubmed
8682296
uniprot
proteins
pubmed
8843393
uniprot
proteins
sequence_length
399
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
uniprot
proteins