NUDT1
entrez
4521
canonical
uniprot
P36639
canonical
ensembl
ENSG00000106268
resolver
ensp
ENSP00000339503
resolver
ensp
ENSP00000343439
resolver
ensp
ENSP00000349148
resolver
ensp
ENSP00000380239
resolver
ensp
ENSP00000380241
resolver
ensp
ENSP00000532476
resolver
ensp
ENSP00000595149
resolver
genesymbol
NUDT1
resolver
genesymbol_syn
MTH1
resolver
hgnc
HGNC:8048
resolver
uniprot
A4D205
resolver
uniprot
Q6LES7
resolver
uniprot
Q6P0Y6
resolver
uniprot
Q7Z7N6
resolver
uniprot
Q8IV95
resolver
uniprot
Q9UBM0
resolver
uniprot
Q9UBM9
resolver
uniprot_entry
8ODP_HUMAN
resolver
uniprot_sec
A4D205
resolver
uniprot_sec
Q6LES7
resolver
uniprot_sec
Q6P0Y6
resolver
uniprot_sec
Q7Z7N6
resolver
uniprot_sec
Q8IV95
resolver
uniprot_sec
Q9UBM0
resolver
uniprot_sec
Q9UBM9
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by 2-oxo-dADP and 8-oxo-dGDP. {ECO:0000269|PubMed:10373420}.
uniprot
proteins
amino_acid_sequence
MGASRLYTLVLVLQPQRVLLGMKKRGFGAGRWNGFGGKVQEGETIEDGARRELQEESGLTVDALHKVGQIVFEFVGEPELMDVHVFCTDSIQGTPVESDEMRPCWFQLDQIPFKDMWPDDSYWFPLLLQKKKFHGYFKFQGQDTILDYTLREVDTV
uniprot
proteins
ec_number
3.6.1.-
uniprot
proteins
ec_number
3.6.1.56
uniprot
proteins
function
FUNCTION: Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool (PubMed:10608900, PubMed:12857738, PubMed:22556419, PubMed:24695224, PubMed:24695225, PubMed:26238318, PubMed:28679043, PubMed:7713500, PubMed:8226881). Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP (PubMed:10373420). Also has a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP (PubMed:10373420, PubMed:11139615). Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A (PubMed:10373420, PubMed:10608900, PubMed:11756418, PubMed:12857738, PubMed:16607562, PubMed:24695224, PubMed:24695225, PubMed:26999531, PubMed:28035004, PubMed:8226881). Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA (PubMed:30304478, PubMed:32144205). Through this antimutagenic activity protects cells from oxidative stress (PubMed:10608900, PubMed:12857738, PubMed:24695224, PubMed:24695225, PubMed:30304478, PubMed:32144205, PubMed:7713500, PubMed:8226881). {ECO:0000269|PubMed:10373420, ECO:0000269|PubMed:10608900, ECO:0000269|PubMed:11139615, ECO:0000269|PubMed:11756418, ECO:0000269|PubMed:12857738, ECO:0000269|PubMed:16607562, ECO:0000269|PubMed:22556419, ECO:0000269|PubMed:24695224, ECO:0000269|PubMed:24695225, ECO:0000269|PubMed:26238318, ECO:0000269|PubMed:26999531, ECO:0000269|PubMed:28035004, ECO:0000269|PubMed:28679043, ECO:0000269|PubMed:30304478, ECO:0000269|PubMed:32144205, ECO:0000269|PubMed:7713500, ECO:0000269|PubMed:8226881}.
uniprot
proteins
mass_dalton
17952
uniprot
proteins
mutagenesis
MUTAGEN 27; /note="F->A: Reduces 2-oxo-dATPase and 8-oxo-dGTPase activities."; /evidence="ECO:0000269|PubMed:11756418"; MUTAGEN 36; /note="G->R: Reduces activity by 97%."; /evidence="ECO:0000269|PubMed:10608900"; MUTAGEN 37; /note="G->F: Loss of activity."; /evidence="ECO:0000269|PubMed:10608900"; MUTAGEN 39; /note="V->E: Loss of activity."; /evidence="ECO:0000269|PubMed:10608900"; MUTAGEN 40; /note="Q->P: Reduces activity by 97%."; /evidence="ECO:0000269|PubMed:10608900"; MUTAGEN 42; /note="G->I: Reduces activity by 60%."; /evidence="ECO:0000269|PubMed:10608900"; MUTAGEN 45; /note="I->K: Loss of activity."; /evidence="ECO:0000269|PubMed:10608900"; MUTAGEN 47; /note="D->P: Loss of activity."; /evidence="ECO:0000269|PubMed:10608900"; MUTAGEN 48; /note="G->M: Loss of activity."; /evidence="ECO:0000269|PubMed:10608900"; MUTAGEN 49; /note="A->P: Loss of activity."; /evidence="ECO:0000269|PubMed:10608900"; MUTAGEN 53; /note="L->P: Loss of activity."; /evidence="ECO:0000269|PubMed:10608900"; MUTAGEN 54; /note="Q->P: Loss of activity."; /evidence="ECO:0000269|PubMed:10608900"; MUTAGEN 55; /note="E->G: Loss of activity."; /evidence="ECO:0000269|PubMed:10608900"; MUTAGEN 56; /note="E->A: Loss of ability to prevent DNA damage. Expected to cause loss of enzyme activity."; /evidence="ECO:0000269|PubMed:24695224"; MUTAGEN 56; /note="E->Y: Loss of activity."; /evidence="ECO:0000269|PubMed:10608900"; MUTAGEN 57; /note="S->R: Loss of activity."; /evidence="ECO:0000269|PubMed:10608900"; MUTAGEN 117; /note="W->A: Greatly reduces or abolishes 2-oxo-dATPase and 8-oxo-dGTPase activities."; /evidence="ECO:0000269|PubMed:11756418"; MUTAGEN 117; /note="W->Y: Enhances 2-oxo-dATPase activity and greatly reduces 8-oxo-dGTPase activity."; /evidence="ECO:0000269|PubMed:11756418"; MUTAGEN 119; /note="D->A,N: Loss of 2-oxo-dATPase activity, reduces 8-oxo-dGTPase activity."; /evidence="ECO:0000269|PubMed:11756418"; MUTAGEN 120; /note="D->A,N: Mildly decreased 2-oxo-dATPase activity, nearly abolishes 8-oxo-dGTPase activity."; /evidence="ECO:0000269|PubMed:28035004"; MUTAGEN 150; /note="L->A: Reduces 2-oxo-dATPase and 8-oxo-dGTPase activities and increases thermolability."; /evidence="ECO:0000269|PubMed:11756418"; MUTAGEN 151..156; /note="Missing: Almost abolishes 2-oxo-dATPase and 8-oxo-dGTPase activities and increases thermolability."; /evidence="ECO:0000269|PubMed:11756418"; MUTAGEN 151; /note="R->A: Reduces 2-oxo-dATPase and 8-oxo-dGTPase activities and increases thermolability."; /evidence="ECO:0000269|PubMed:11756418"; MUTAGEN 152..156; /note="Missing: Greatly reduces 2-oxo-dATPase and 8-oxo-dGTPase activities and increases thermolability."; /evidence="ECO:0000269|PubMed:11756418"; MUTAGEN 152; /note="E->A: Reduces 2-oxo-dATPase and 8-oxo-dGTPase activities and increases thermolability."; /evidence="ECO:0000269|PubMed:11756418"; MUTAGEN 153..156; /note="Missing: Reduces 2-oxo-dATPase and 8-oxo-dGTPase activities and increases thermolability."; /evidence="ECO:0000269|PubMed:11756418"; MUTAGEN 153; /note="V->A: Reduces 2-oxo-dATPase and 8-oxo-dGTPase activities and increases thermolability."; /evidence="ECO:0000269|PubMed:11756418"; MUTAGEN 154..156; /note="Missing: Slightly enhances 2-oxo-dATPase and 8-oxo-dGTPase activities and increases thermolability."; /evidence="ECO:0000269|PubMed:11756418"; MUTAGEN 154; /note="D->A: Enhances 2-oxo-dATPase and 8-oxo-dGTPase activities and increases thermolability."; /evidence="ECO:0000269|PubMed:11756418"; MUTAGEN 155; /note="T->A: Reduces 2-oxo-dATPase and 8-oxo-dGTPase activities and increases thermolability."; /evidence="ECO:0000269|PubMed:11756418"; MUTAGEN 156; /note="V->A: Slightly reduces 2-oxo-dATPase and 8-oxo-dGTPase activities and increases thermolability."; /evidence="ECO:0000269|PubMed:11756418
uniprot
proteins
post_translational_modification
PTM: The N-terminus is blocked.
uniprot
proteins
protein_family
Nudix hydrolase family
uniprot
proteins
pubmed
10373420
uniprot
proteins
pubmed
10536140
uniprot
proteins
pubmed
10608900
uniprot
proteins
pubmed
11139615
uniprot
proteins
pubmed
11756418
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
12857738
uniprot
proteins
pubmed
15133035
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15516784
uniprot
proteins
pubmed
16607562
uniprot
proteins
pubmed
16774934
uniprot
proteins
pubmed
17142918
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21787772
uniprot
proteins
pubmed
22556419
uniprot
proteins
pubmed
24695224
uniprot
proteins
pubmed
24695225
uniprot
proteins
pubmed
26238318
uniprot
proteins
pubmed
26999531
uniprot
proteins
pubmed
28035004
uniprot
proteins
pubmed
28679043
uniprot
proteins
pubmed
30304478
uniprot
proteins
pubmed
32144205
uniprot
proteins
pubmed
7713500
uniprot
proteins
pubmed
7782328
uniprot
proteins
pubmed
8226881
uniprot
proteins
pubmed
9211940
uniprot
proteins
sequence_length
156
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform p18]: Cytoplasm, cytosol {ECO:0000269|PubMed:12857738, ECO:0000269|PubMed:16607562, ECO:0000269|PubMed:7782328}. Mitochondrion matrix {ECO:0000269|PubMed:7782328, ECO:0000305|PubMed:12857738, ECO:0000305|PubMed:16607562}. Nucleus {ECO:0000269|PubMed:12857738, ECO:0000269|PubMed:7782328}. Note=Mostly present in cytosol (PubMed:7782328). A minor proportion is mitochondrial (PubMed:7782328). A very small amount of the protein is associated with nuclei (PubMed:7782328). {ECO:0000269|PubMed:16607562, ECO:0000269|PubMed:7782328}.; SUBCELLULAR LOCATION: [Isoform p26]: Mitochondrion matrix {ECO:0000269|PubMed:16607562}.
uniprot
proteins