CEP44
entrez
80817
canonical
uniprot
Q9C0F1
canonical
ensembl
ENSG00000164118
resolver
ensp
ENSP00000296519
resolver
ensp
ENSP00000389427
resolver
ensp
ENSP00000408221
resolver
ensp
ENSP00000423153
resolver
ensp
ENSP00000523466
resolver
ensp
ENSP00000523467
resolver
ensp
ENSP00000523468
resolver
ensp
ENSP00000597537
resolver
ensp
ENSP00000597539
resolver
ensp
ENSP00000658803
resolver
ensp
ENSP00000695206
resolver
ensp
ENSP00000695207
resolver
ensp
ENSP00000790219
resolver
ensp
ENSP00000790220
resolver
genesymbol
CEP44
resolver
genesymbol_syn
KIAA1712
resolver
hgnc
HGNC:29356
resolver
uniprot
A8K8W9
resolver
uniprot
A8MW11
resolver
uniprot
B3KT53
resolver
uniprot
D3DP42
resolver
uniprot
Q8IXZ4
resolver
uniprot_entry
CEP44_HUMAN
resolver
uniprot_sec
A8K8W9
resolver
uniprot_sec
A8MW11
resolver
uniprot_sec
B3KT53
resolver
uniprot_sec
D3DP42
resolver
uniprot_sec
Q8IXZ4
resolver
amino_acid_sequence
MATGDLKRSLRNLEQVLRLLNYPEEVDCVGLIKGDPAASLPIISYSFTSYSPYVTELIMESNVELIAKNDLRFIDAVYKLLRDQFNYKPILTKKQFIQCGFAEWKIQIVCDILNCVMKKHKELSSLQKIPSQQRKKISSGKSEPPLGNEKISAEAVGVDISGRFMTSGKKKAVVIRHLYNEDNVDISEDTLSPITDVNEAVDVSDLNATEIKMPEVKVPEIKAEQQDVNVNPEITALQTMLAECQENLKKLTSIEKRLDCLEQKMKGKVMVDENTWTNLLSRVTLLETEMLLSKKNDEFIEFNEVSEDYASCSDMDLLNPHRKSEVERPASIPLSSGYSTASSDSTPRASTVNYCGLNEISEETTIQKMERMKKMFEETAELLKCPNHYL
uniprot
proteins
function
FUNCTION: Centriole-enriched microtubule-binding protein involved in centriole biogenesis. In collaboration with CEP295 and POC1B, is required for the centriole-to-centrosome conversion by ensuring the formation of bona fide centriole wall (PubMed:32060285). Functions as a linker component that maintains centrosome cohesion. Associates with CROCC and regulates its stability and localization to the centrosome (PubMed:31974111). {ECO:0000269|PubMed:31974111, ECO:0000269|PubMed:32060285}.
uniprot
proteins
mass_dalton
44140
uniprot
proteins
mutagenesis
MUTAGEN 68..88; /note="KNDLRFIDAVYKLLRDQFNYK->DNDLEFIDAVYDLLDQFNYD: Loss of binding to microtubules and location to centrioles."; /evidence="ECO:0000269|PubMed:32060285
uniprot
proteins
pubmed
11214970
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21399614
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
31974111
uniprot
proteins
pubmed
32060285
uniprot
proteins
sequence_length
390
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21399614, ECO:0000269|PubMed:31974111}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:31974111, ECO:0000269|PubMed:32060285}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:21399614}. Midbody {ECO:0000269|PubMed:21399614}. Note=Localizes to the proximal end of mother and daughter centrioles. {ECO:0000269|PubMed:31974111, ECO:0000269|PubMed:32060285}.
uniprot
proteins