Psme3
entrez
19192
canonical
uniprot
P61290
canonical
ensembl
ENSMUSG00000078652
resolver
ensp
ENSMUSP00000019470
resolver
ensp
ENSMUSP00000343801
resolver
enst
ENSMUST00000019470
resolver
genesymbol
Psme3
resolver
uniprot
O35563
resolver
uniprot
P97373
resolver
uniprot
Q12920
resolver
uniprot
Q13172
resolver
uniprot
Q4FK54
resolver
uniprot
Q9BQD9
resolver
uniprot_entry
PSME3_MOUSE
resolver
uniprot_entry
Q4FK54_MOUSE
resolver
uniprot_sec
O35563
resolver
uniprot_sec
P97373
resolver
uniprot_sec
Q12920
resolver
uniprot_sec
Q13172
resolver
uniprot_sec
Q9BQD9
resolver
amino_acid_sequence
MASLLKVDQEVKLKVDSFRERITSEAEDLVANFFPKKLLELDSFLKEPILNIHDLTQIHSDMNLPVPDPILLTNSHDGLDGPTYKKRRLDECEEAFQGTKVFVMPNGMLKSNQQLVDIIEKVKPEIRLLIEKCNTVKMWVQLLIPRIEDGNNFGVSIQEETVAELRTVESEAASYLDQISRYYITRAKLVSKIAKYPHVEDYRRTVTEIDEKEYISLRLIISELRNQYVTLHDMILKNIEKIKRPRSSNAETLY
uniprot
proteins
function
FUNCTION: Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (By similarity). {ECO:0000250|UniProtKB:P61289}.
uniprot
proteins
mass_dalton
29506
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MAP3K3. Phosphorylation at Ser-247 promotes its association with CCAR2 (By similarity). {ECO:0000250|UniProtKB:P61289, ECO:0000269|PubMed:12650640}.; PTM: Acetylation at the major site Lys-195 is important for oligomerization and ability to degrade its target substrates. Deacetylated by SIRT1 (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
PA28 family
uniprot
proteins
pubmed
10608895
uniprot
proteins
pubmed
12650640
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9162094
uniprot
proteins
pubmed
9218537
uniprot
proteins
pubmed
9590240
uniprot
proteins
sequence_length
254
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12650640}. Cytoplasm {ECO:0000269|PubMed:12650640}. Note=Localizes to the cytoplasm during mitosis following nuclear envelope breakdown at this distinct stage of the cell cycle which allows its interaction with MAP3K3 kinase.
uniprot
proteins