Msmo1
entrez
66234
canonical
uniprot
Q9CRA4
canonical
ensembl
ENSMUSG00000031604
resolver
ensp
ENSMUSP00000034015
resolver
ensp
ENSMUSP00000218524
resolver
ensp
ENSMUSP00000218527
resolver
enst
ENSMUST00000034015
resolver
genesymbol
Msmo1
resolver
genesymbol_syn
Sc4mol
resolver
uniprot
Q543V8
resolver
uniprot_entry
MSMO1_MOUSE
resolver
uniprot_sec
Q543V8
resolver
amino_acid_sequence
MATNKSVGVFSSASLAVEYVDSLLPENPLQEPFKNAWVYMLDNYTKFQIATWGSLIVHEAIYFLFSLPGFLFQFIPYMRKYKIQKDKPETFEGQWKCLKKILFNHFFIQLPLICGTYYFTEFFNIPYDWERMPRWYLTLARCLGCAVIEDTWHYFLHRLLHHKRIYKYIHKVHHEFQAPFGIEAEYAHPLETLILGTGFFIGIVLLCDHVILLWAWVTIRLLETIDVHSGYDIPLNPLNLVPFYTGARHHDFHHMNFIGNYASTFTWWDKLFGTDAQYHAYIEKSKKLGKKSD
uniprot
proteins
ec_number
1.14.18.9
uniprot
proteins
function
FUNCTION: Catalyzes the three-step monooxygenation required for the demethylation of 4,4-dimethyl and 4alpha-methylsterols, which can be subsequently metabolized to cholesterol. {ECO:0000250|UniProtKB:Q15800}.
uniprot
proteins
mass_dalton
34772
uniprot
proteins
pathway_participation
PATHWAY: Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 3/6. {ECO:0000250|UniProtKB:Q15800}.; PATHWAY: Steroid biosynthesis; cholesterol biosynthesis. {ECO:0000250|UniProtKB:Q15800}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by MARCHF6, leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q15800}.
uniprot
proteins
protein_family
Sterol desaturase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
293
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q15800}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q15800}.
uniprot
proteins
transmembrane_region
TRANSMEM 55..75; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 100..120; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 199..219; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins