Sfrp1
entrez
20377
canonical
uniprot
Q8C4U3
canonical
ensembl
ENSMUSG00000031548
resolver
ensp
ENSMUSP00000033952
resolver
enst
ENSMUST00000033952
resolver
genesymbol
Sfrp1
resolver
uniprot
O08861
resolver
uniprot
Q505A2
resolver
uniprot
Q8R1J4
resolver
uniprot_entry
SFRP1_MOUSE
resolver
uniprot_sec
O08861
resolver
uniprot_sec
Q505A2
resolver
uniprot_sec
Q8R1J4
resolver
amino_acid_sequence
MGVGRSARGRGGAASGVLLALAAALLAAGSASEYDYVSFQSDIGSYQSGRFYTKPPQCVDIPVDLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHMGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNTTEASKPQGTTVCPPCDNELKSEAIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKELKRLVLFLKNGADCPCHQLDNLSHNFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKRMKNHECPTFQSVFK
uniprot
proteins
function
FUNCTION: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase. In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription (By similarity). {ECO:0000250, ECO:0000269|PubMed:15306229}.
uniprot
proteins
mass_dalton
35413
uniprot
proteins
protein_family
Secreted frizzled-related protein (sFRP) family
uniprot
proteins
pubmed
10640709
uniprot
proteins
pubmed
15306229
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19188438
uniprot
proteins
pubmed
27713059
uniprot
proteins
pubmed
9096311
uniprot
proteins
pubmed
9739103
uniprot
proteins
sequence_length
314
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Cell membrane or extracellular matrix-associated. Released by heparin-binding (By similarity). {ECO:0000250}.
uniprot
proteins