Abcc2
entrez
25303
canonical
uniprot
Q63120
canonical
ensembl
ENSRNOG00000046727
resolver
ensembl
ENSRNOG00055004149
resolver
ensembl
ENSRNOG00060026873
resolver
ensembl
ENSRNOG00065028827
resolver
ensp
ENSRNOP00000064799
resolver
ensp
ENSRNOP00055005100
resolver
ensp
ENSRNOP00060039014
resolver
ensp
ENSRNOP00065040950
resolver
enst
ENSRNOT00000070861
resolver
enst
ENSRNOT00055006662
resolver
enst
ENSRNOT00060046915
resolver
enst
ENSRNOT00065049865
resolver
genesymbol
Abcc2
resolver
genesymbol_syn
Cmoat
resolver
genesymbol_syn
Cmrp
resolver
genesymbol_syn
Mrp2
resolver
uniprot
Q63145
resolver
uniprot_entry
MRP2_RAT
resolver
uniprot_sec
Q63145
resolver
amino_acid_sequence
MDKFCNSTFWDLSLLESPEADLPLCFEQTVLVWIPLGFLWLLAPWQLYSVYRSRTKRSSITKFYLAKQVFVVFLLILAAIDLSLALTEDTGQATVPPVRYTNPILYLCTWLLVLAVQHSRQWCVRKNSWFLSLFWILSVLCGVFQFQTLIRALLKDSKSNMAYSYLFFVSYGFQIVLLILTAFSGPSDSTQTPSVTASFLSSITFSWYDRTVLKGYKHPLTLEDVWDIDEGFKTRSVTSKFEAAMTKDLQKARQAFQRRLQKSQRKPEATLHGLNKKQSQSQDVLVLEEAKKKSEKTTKDYPKSWLIKSLFKTFHVVILKSFILKLIHDLLVFLNPQLLKLLIGFVKSSNSYVWFGYICAILMFAVTLIQSFCLQSYFQHCFVLGMCVRTTVMSSIYKKALTLSNLARKQYTIGETVNLMSVDSQKLMDATNYMQLVWSSVIQITLSIFFLWRELGPSILAGVGVMVLLIPVNGVLATKIRNIQVQNMKNKDKRLKIMNEILSGIKILKYFAWEPSFQEQVQGIRKKELKNLLRFGQLQSLLIFILQITPILVSVVTFSVYVLVDSANVLNAEKAFTSITLFNILRFPLSMLPMVTSSILQASVSVDRLERYLGGDDLDTSAIRRVSNFDKAVKFSEASFTWDPDLEATIQDVNLDIKPGQLVAVVGTVGSGKSSLVSAMLGEMENVHGHITIQGSTAYVPQQSWIQNGTIKDNILFGSEYNEKKYQQVLKACALLPDLEILPGGDMAEIGEKGINLSGGQKQRVSLARAAYQDADIYILDDPLSAVDAHVGKHIFNKVVGPNGLLAGKTRIFVTHGIHFLPQVDEIVVLGKGTILEKGSYRDLLDKKGVFARNWKTFMKHSGPEGEATVNNDSEAEDDDDGLIPTMEEIPEDAASLAMRRENSLRRTLSRSSRSSSRRGKSLKNSLKIKNVNVLKEKEKEVEGQKLIKKEFVETGKVKFSIYLKYLQAVGWWSILFIILFYGLNNVAFIGSNLWLSAWTSDSDNLNGTNNSSSHRDMRIGVFGALGLAQGICLLISTLWSIYACRNASKALHGQLLTNILRAPMRFFDTTPTGRIVNRFSGDISTVDDLLPQTLRSWMMCFFGIAGTLVMICMATPVFAIIIIPLSILYISVQVFYVATSRQLRRLDSVTKSPIYSHFSETVTGLPIIRAFEHQQRFLAWNEKQIDINQKCVFSWITSNRWLAIRLELVGNLVVFCSALLLVIYRKTLTGDVVGFVLSNALNITQTLNWLVRMTSEAETNIVAVERISEYINVENEAPWVTDKRPPADWPRHGEIQFNNYQVRYRPELDLVLKGITCNIKSGEKVGVVGRTGAGKSSLTNCLFRILESAGGQIIIDGIDVASIGLHDLRERLTIIPQDPILFSGSLRMNLDPFNKYSDEEVWRALELAHLRSFVSGLQLGLLSEVTEGGDNLSIGQRQLLCLGRAVLRKSKILVLDEATAAVDLETDSLIQTTIRKEFSQCTVITIAHRLHTIMDSDKIMVLDNGKIVEYGSPEELLSNRGSFYLMAKEAGIENVNHTEL
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Abcc2 are a cause of hereditary conjugated hyperbilirubinemia (EHBR). {ECO:0000269|PubMed:8599091, ECO:0000269|Ref.3}.
uniprot
proteins
ec_number
7.6.2.-
uniprot
proteins
ec_number
7.6.2.2
uniprot
proteins
ec_number
7.6.2.3
uniprot
proteins
function
FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyzes ATP to enable active transport of substrates conjugated with glucuronate, glutathione or sulfate. Operates at apical membranes of polarized cells such as hepatocytes, renal and intestinal epithelial cells where it mediates hepatobiliary and renal excretion of conjugated substrates (PubMed:10220572, PubMed:10421658, PubMed:11248200, PubMed:8662992). Involved in canalicular bile production. Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin, enabling bilirubin detoxification (PubMed:9355767, PubMed:10421658). Mediates the efflux of steroid glucuronates from intestine and liver into the intestinal lumen. Shares substrate specificity with MRP3 but displays lower affinity and higher transport velocity toward androgen conjugates such as testosterone and dihydrotestosterone glucuronates as well as toward estrogen conjugates including estradiol, estrone and estriol glucuronates (By similarity). Transports glutathione conjugate leukotriene C4 (LTC4) and related cysteinyl leukotrienes (PubMed:8662992, PubMed:10220572, PubMed:11306690). Displays selective transporter activity toward sulfated conjugates, transports sulfated bile salts such as taurolithocholate sulfate but is inactive toward androgen sulfates (PubMed:11248200) (By similarity). Transports various xenobiotics. Confers resistance to several anticancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine, by decreasing accumulation of these drugs in cells (By similarity). {ECO:0000250|UniProtKB:Q92887, ECO:0000269|PubMed:10220572, ECO:0000269|PubMed:10421658, ECO:0000269|PubMed:11248200, ECO:0000269|PubMed:11306690, ECO:0000269|PubMed:8662992, ECO:0000269|PubMed:9355767}.
uniprot
proteins
mass_dalton
173384
uniprot
proteins
mutagenesis
MUTAGEN 308; /note="K->M: No significant effect on transporter activity toward leukotriene E4 and estradiol 17-glucuronate substrates. Retains protein expression."; /evidence="ECO:0000269|PubMed:11306690"; MUTAGEN 320; /note="K->M: No significant effect on transporter activity toward leukotriene E4 and estradiol 17-glucuronate substrates. Retains protein expression."; /evidence="ECO:0000269|PubMed:11306690"; MUTAGEN 325; /note="K->M: Abolishes the transporter activity toward leukotriene C4, decreases the transporter activity toward leukotriene D4, but retains normal transporter activity toward leukotriene E4 and estradiol 17-glucuronate. Retains protein expression."; /evidence="ECO:0000269|PubMed:11306690"; MUTAGEN 325; /note="K->R: Markedly decreases the transporter activity toward leukotriene C4 and estradiol 17-glucuronate substrates."; /evidence="ECO:0000269|PubMed:11306690"; MUTAGEN 329; /note="D->E: Decreases the transporter activity toward estradiol 17-glucuronate."; /evidence="ECO:0000269|PubMed:11306690"; MUTAGEN 329; /note="D->N: Abolishes the transporter activity toward leukotriene C4 and estradiol 17-glucuronate substrates. Retains protein expression."; /evidence="ECO:0000269|PubMed:11306690"; MUTAGEN 586; /note="R->I: Markedly decreases the transporter activity toward leukotriene C4. Increases the transporter activity toward estradiol 17-glucuronate."; /evidence="ECO:0000269|PubMed:11306690"; MUTAGEN 586; /note="R->K: Decreases the transporter activity toward leukotriene C4 and estradiol 17-glucuronate substrates."; /evidence="ECO:0000269|PubMed:11306690"; MUTAGEN 586; /note="R->L: Markedly decreases the transporter activity toward leukotriene C4, decreases the transporter activity toward leukotriene D4 and leukotriene E4, but retains normal transporter activity toward estradiol 17-glucuronate. Retains protein expression."; /evidence="ECO:0000269|PubMed:11306690"; MUTAGEN 1019; /note="R->M: No significant effect on transporter activity toward leukotriene E4 and estradiol 17-glucuronate substrates. Retains protein expression."; /evidence="ECO:0000269|PubMed:11306690"; MUTAGEN 1096; /note="R->L: No significant effect on transporter activity toward leukotriene E4 and estradiol 17-glucuronate substrates. Retains protein expression."; /evidence="ECO:0000269|PubMed:11306690"; MUTAGEN 1206; /note="R->M: Loss of transporter activity. Maintains detectable albeit reduced protein expression."; /evidence="ECO:0000269|PubMed:11306690"; MUTAGEN 1208; /note="E->Q: Loss of transporter activity. Retains protein expression."; /evidence="ECO:0000269|PubMed:11306690
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCC family
uniprot
proteins
protein_family
Conjugate transporter (TC 3.A.1.208) subfamily
uniprot
proteins
pubmed
10220572
uniprot
proteins
pubmed
10421658
uniprot
proteins
pubmed
11248200
uniprot
proteins
pubmed
11306690
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8599091
uniprot
proteins
pubmed
8662992
uniprot
proteins
pubmed
9355767
uniprot
proteins
sequence_length
1541
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:10220572, ECO:0000269|PubMed:8662992}; Multi-pass membrane protein {ECO:0000255}. Note=Localized to the canalicular membrane of hepatocytes. {ECO:0000269|PubMed:8662992}.
uniprot
proteins
transmembrane_region
TRANSMEM 27..47; /note="Helical; Name=1"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 68..88; /note="Helical; Name=2"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 93..113; /note="Helical; Name=3"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 126..146; /note="Helical; Name=4"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 165..185; /note="Helical; Name=5"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 310..330; /note="Helical; Name=6"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 357..377; /note="Helical; Name=7"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 434..454; /note="Helical; Name=8"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 458..478; /note="Helical; Name=9"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 541..561; /note="Helical; Name=10"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 584..604; /note="Helical; Name=11"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 968..988; /note="Helical; Name=12"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1030..1050; /note="Helical; Name=13"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1094..1114; /note="Helical; Name=14"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1116..1136; /note="Helical; Name=15"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1208..1228; /note="Helical; Name=16"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1231..1251; /note="Helical; Name=17"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441
uniprot
proteins