Pum3
entrez
499339
canonical
uniprot
Q562C7
canonical
ensembl
ENSRNOG00000012574
resolver
ensp
ENSRNOP00000034834
resolver
genesymbol
Pum3
resolver
uniprot
Q4G054
resolver
uniprot_entry
PUM3_RAT
resolver
uniprot_sec
Q4G054
resolver
amino_acid_sequence
MEVKGKKKITGKSPQTSQGKNKFHKNSESSSAKAFPRKAAKEGGPKVTSKNFEKGATKPGKKRVKQFKNKPQGGKGPKDKFQKANKFNKKRKFQPDGKSDESAAKKPKWDDFKKKKKELKQNRQLSDKTNYDVVVRAKHIWESLRRKDCDKEKRVKLMSDLQKLIQGKIKTIAFAHDSTRVIQCLIQYGSEEQRKWAFEELQGDLVELSKAKYSRNIVKKFLMYGSKPQIAEIIRSFKGHVRKMLRHSEASAIVEYAYNDKAILEQRNMLTEELYGNTFQLYKSADHPTLEKVLEVQPGKLELILDEMKQILTPMAQKEAVIKHSLVHKVFLDFFTYAPPKLRSELIEAIREAVVYLAHTHDGARVAMHCLWHGTPKDRKVIVKTMKTYVEKIANGQYSHLVLLAAFDCIDDTKLVKQIIISEVISSLPSIVNDKYGRKVLLYLLSPRAPAHLVPEIIQLLQKGDGNAHSKKDTAIRRRELLESISPALLSYLQGHTREVVLDKSVCVLVSDILGSATGDAQPAMDAIAGLAAEELYPGGKDGELHIAEHPAGHLVLKWLIEQDKKIKENGKEGCFAKTLVECVGMKNLKSWASINRGAIVLSSLLQSCDQDVVNKVKAGLKTLIPTLEKTKSTSKGIQTLLEKLTA
uniprot
proteins
function
FUNCTION: Inhibits the poly(ADP-ribosyl)ation activity of PARP1 and the degradation of PARP1 by CASP3 following genotoxic stress. Binds to double-stranded RNA or DNA without sequence specificity. Involved in development of the eye and of primordial germ cells. {ECO:0000250|UniProtKB:Q15397, ECO:0000250|UniProtKB:X1WGX5}.
uniprot
proteins
mass_dalton
72786
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
647
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q15397}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q15397}. Chromosome {ECO:0000250|UniProtKB:Q15397}. Note=Localizes predominantly in the nucleolus with minor punctate signals in the nucleoplasm. {ECO:0000250|UniProtKB:Q15397}.
uniprot
proteins