AS3MT
entrez
57412
canonical
uniprot
Q9HBK9
canonical
ensembl
ENSG00000214435
resolver
ensp
ENSP00000358896
resolver
genesymbol
AS3MT
resolver
genesymbol_syn
CYT19
resolver
hgnc
HGNC:17452
resolver
uniprot
A6NP79
resolver
uniprot
Q0VDK3
resolver
uniprot
Q0VDK4
resolver
uniprot
Q5PZ02
resolver
uniprot_entry
AS3MT_HUMAN
resolver
uniprot_sec
A6NP79
resolver
uniprot_sec
Q0VDK3
resolver
uniprot_sec
Q0VDK4
resolver
uniprot_sec
Q5PZ02
resolver
amino_acid_sequence
MAALRDAEIQKDVQTYYGQVLKRSADLQTNGCVTTARPVPKHIREALQNVHEEVALRYYGCGLVIPEHLENCWILDLGSGSGRDCYVLSQLVGEKGHVTGIDMTKGQVEVAEKYLDYHMEKYGFQASNVTFIHGYIEKLGEAGIKNESHDIVVSNCVINLVPDKQQVLQEAYRVLKHGGELYFSDVYTSLELPEEIRTHKVLWGECLGGALYWKELAVLAQKIGFCPPRLVTANLITIQNKELERVIGDCRFVSATFRLFKHSKTGPTKRCQVIYNGGITGHEKELMFDANFTFKEGEIVEVDEETAAILKNSRFAQDFLIRPIGEKLPTSGGCSALELKDIITDPFKLAEESDSMKSRCVPDAAGGCCGTKKSC
uniprot
proteins
ec_number
2.1.1.137
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals (PubMed:16407288, PubMed:25997655). It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2 (PubMed:16407288, PubMed:25997655). Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (PubMed:16407288, PubMed:25997655). {ECO:0000269|PubMed:16407288, ECO:0000269|PubMed:25997655}.
uniprot
proteins
mass_dalton
41748
uniprot
proteins
protein_family
Arsenite methyltransferase family
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16407288
uniprot
proteins
pubmed
18334919
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22005461
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25997655
uniprot
proteins
sequence_length
375
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8VHT6}.
uniprot
proteins