Elovl7
entrez
361895
canonical
uniprot
D4ADY9
canonical
ensembl
ENSRNOG00000010450
resolver
ensembl
ENSRNOG00055011646
resolver
ensembl
ENSRNOG00060003699
resolver
ensembl
ENSRNOG00065020984
resolver
ensp
ENSRNOP00000014074
resolver
ensp
ENSRNOP00055015968
resolver
ensp
ENSRNOP00060004544
resolver
ensp
ENSRNOP00065028732
resolver
enst
ENSRNOT00000014074
resolver
enst
ENSRNOT00055019791
resolver
enst
ENSRNOT00060006130
resolver
enst
ENSRNOT00065035649
resolver
genesymbol
Elovl7
resolver
uniprot_entry
ELOV7_RAT
resolver
amino_acid_sequence
MAFSDLTSRTVRFYDNWIKDADPRVENWLLMSSPLPQTIILGLYVYFVTSLGPKLMENRKPFELKKAMITYNFFIVLFSVYMCYEFVMSGWGTGYSFRCDIVDYSQSPRAMRMVHTCWLYYFSKFIELFDTIFFVLRKKNSQVTFLHVFHHTIMPWTWWFGVKFAAGGLGTFHALLNTAVHVVMYFYYGLCAMGPAYQKYLWWKKHLTSLQLVQFVLVTVHIGQIFFMEDCNYQYPVFLYIIMSYGCIFLLLFLHFWYRAYTKGQRLPKTMENGNCKSKHH
uniprot
proteins
ec_number
2.3.1.199
uniprot
proteins
function
FUNCTION: Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate in the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000255|HAMAP-Rule:MF_03207}.
uniprot
proteins
mass_dalton
33547
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03207}.
uniprot
proteins
protein_family
ELO family
uniprot
proteins
protein_family
ELOVL7 subfamily
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
281
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000255|HAMAP-Rule:MF_03207}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03207}.
uniprot
proteins
transmembrane_region
TRANSMEM 28..48; /note="Helical; Name=1"; /evidence="ECO:0000255|HAMAP-Rule:MF_03207"; TRANSMEM 73..93; /note="Helical; Name=2"; /evidence="ECO:0000255|HAMAP-Rule:MF_03207"; TRANSMEM 116..136; /note="Helical; Name=3"; /evidence="ECO:0000255|HAMAP-Rule:MF_03207"; TRANSMEM 143..162; /note="Helical; Name=4"; /evidence="ECO:0000255|HAMAP-Rule:MF_03207"; TRANSMEM 177..197; /note="Helical; Name=5"; /evidence="ECO:0000255|HAMAP-Rule:MF_03207"; TRANSMEM 207..227; /note="Helical; Name=6"; /evidence="ECO:0000255|HAMAP-Rule:MF_03207"; TRANSMEM 237..257; /note="Helical; Name=7"; /evidence="ECO:0000255|HAMAP-Rule:MF_03207
uniprot
proteins