ITGAL
entrez
3683
canonical
uniprot
P20701
canonical
ensembl
ENSG00000005844
resolver
ensp
ENSP00000349252
resolver
ensp
ENSP00000350886
resolver
ensp
ENSP00000545782
resolver
genesymbol
ITGAL
resolver
genesymbol_syn
CD11A
resolver
hgnc
HGNC:6148
resolver
uniprot
B2RAL6
resolver
uniprot
O43746
resolver
uniprot
Q45H73
resolver
uniprot
Q96HB1
resolver
uniprot
Q9UBC8
resolver
uniprot_entry
B2RAL6_HUMAN
resolver
uniprot_entry
ITAL_HUMAN
resolver
uniprot_sec
O43746
resolver
uniprot_sec
Q45H73
resolver
uniprot_sec
Q96HB1
resolver
uniprot_sec
Q9UBC8
resolver
amino_acid_sequence
MKDSCITVMAMALLSGFFFFAPASSYNLDVRGARSFSPPRAGRHFGYRVLQVGNGVIVGAPGEGNSTGSLYQCQSGTGHCLPVTLRGSNYTSKYLGMTLATDPTDGSILACDPGLSRTCDQNTYLSGLCYLFRQNLQGPMLQGRPGFQECIKGNVDLVFLFDGSMSLQPDEFQKILDFMKDVMKKLSNTSYQFAAVQFSTSYKTEFDFSDYVKRKDPDALLKHVKHMLLLTNTFGAINYVATEVFREELGARPDATKVLIIITDGEATDSGNIDAAKDIIRYIIGIGKHFQTKESQETLHKFASKPASEFVKILDTFEKLKDLFTELQKKIYVIEGTSKQDLTSFNMELSSSGISADLSRGHAVVGAVGAKDWAGGFLDLKADLQDDTFIGNEPLTPEVRAGYLGYTVTWLPSRQKTSLLASGAPRYQHMGRVLLFQEPQGGGHWSQVQTIHGTQIGSYFGGELCGVDVDQDGETELLLIGAPLFYGEQRGGRVFIYQRRQLGFEEVSELQGDPGYPLGRFGEAITALTDINGDGLVDVAVGAPLEEQGAVYIFNGRHGGLSPQPSQRIEGTQVLSGIQWFGRSIHGVKDLEGDGLADVAVGAESQMIVLSSRPVVDMVTLMSFSPAEIPVHEVECSYSTSNKMKEGVNITICFQIKSLIPQFQGRLVANLTYTLQLDGHRTRRRGLFPGGRHELRRNIAVTTSMSCTDFSFHFPVCVQDLISPINVSLNFSLWEEEGTPRDQRAQGKDIPPILRPSLHSETWEIPFEKNCGEDKKCEANLRVSFSPARSRALRLTAFASLSVELSLSNLEEDAYWVQLDLHFPPGLSFRKVEMLKPHSQIPVSCEELPEESRLLSRALSCNVSSPIFKAGHSVALQMMFNTLVNSSWGDSVELHANVTCNNEDSDLLEDNSATTIIPILYPINILIQDQEDSTLYVSFTPKGPKIHQVKHMYQVRIQPSIHDHNIPTLEAVVGVPQPPSEGPITHQWSVQMEPPVPCHYEDLERLPDAAEPCLPGALFRCPVVFRQEILVQVIGTLELVGEIEASSMFSLCSSLSISFNSSKHFHLYGSNASLAQVVMKVDVVYEKQMLYLYVLSGIGGLLLLLLIFIVLYKVGFFKRNLKEKMEAGRGVPNGIPAEDSEQLASGQEAGDPGCLKPLHEKDSESGGGKD
uniprot
proteins
function
FUNCTION: Integrin ITGAL/ITGB2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4 (PubMed:10846180, PubMed:12526797, PubMed:1676048, PubMed:3086451). Integrin ITGAL/ITGB2 is a receptor for F11R (PubMed:11812992, PubMed:15528364). Integrin ITGAL/ITGB2 is a receptor for the secreted form of ubiquitin-like protein ISG15; the interaction is mediated by ITGAL (PubMed:29100055). Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Acts as a platform at the immunological synapse to translate TCR engagement and density of the ITGAL ligand ICAM1 into graded adhesion (PubMed:38195629). Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity). Integrin ITGAL/ITGB2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590). Integrins ITGAL:ITGB2 functions as a receptor of the neuron-specific adhesion molecule ICAM5 ensuring neuron cell-leukocyte adhesion (PubMed:10741396). Integrin ITGAL/ITGB2 that functions as a signaling receptor of ICAM2, ensuring leukocyte cell-cell adhesion on resting cells (PubMed:1676048). {ECO:0000250|UniProtKB:P24063, ECO:0000269|PubMed:10741396, ECO:0000269|PubMed:10846180, ECO:0000269|PubMed:11812992, ECO:0000269|PubMed:12526797, ECO:0000269|PubMed:15356110, ECO:0000269|PubMed:15528364, ECO:0000269|PubMed:1676048, ECO:0000269|PubMed:23775590, ECO:0000269|PubMed:29100055, ECO:0000269|PubMed:3086451, ECO:0000269|PubMed:38195629}.
uniprot
proteins
mass_dalton
128770
uniprot
proteins
mutagenesis
MUTAGEN 1165; /note="S->A: Abolishes phosphorylation and MEM-83-activated T-cell adhesion to ICAM1. Abolishes integrin alpha-L/beta-2 activation by CXCL12 and TERF2IP/RAP1. Does not affect heterodimerization of cell surface expression. Does not affect TCR- or phorbol ester-activated T-cell adhesion to ICAM1."; /evidence="ECO:0000269|PubMed:16301335
uniprot
proteins
post_translational_modification
PTM: In resting T-cells, up to 40% of surface ITGAL is constitutively phosphorylated. Phosphorylation causes conformational changes needed for ligand binding and is necessary for activation by some physiological agents. {ECO:0000269|PubMed:16301335}.
uniprot
proteins
protein_family
Integrin alpha chain family
uniprot
proteins
pubmed
10493829
uniprot
proteins
pubmed
10493852
uniprot
proteins
pubmed
10741396
uniprot
proteins
pubmed
10846180
uniprot
proteins
pubmed
11812992
uniprot
proteins
pubmed
12526797
uniprot
proteins
pubmed
15356110
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15528364
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
15684041
uniprot
proteins
pubmed
15728350
uniprot
proteins
pubmed
16301335
uniprot
proteins
pubmed
1676048
uniprot
proteins
pubmed
18020948
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
23775590
uniprot
proteins
pubmed
2537322
uniprot
proteins
pubmed
26936951
uniprot
proteins
pubmed
27055590
uniprot
proteins
pubmed
29100055
uniprot
proteins
pubmed
3086451
uniprot
proteins
pubmed
38195629
uniprot
proteins
pubmed
7479767
uniprot
proteins
pubmed
8097887
uniprot
proteins
pubmed
8099450
uniprot
proteins
pubmed
8103515
uniprot
proteins
pubmed
8805579
uniprot
proteins
sequence_length
1170
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15684041, ECO:0000269|PubMed:16301335}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:15684041}. Note=Upon antigen recognition by the TCR, is recruited to lipid rafts (PubMed:15684041). {ECO:0000269|PubMed:15684041}.
uniprot
proteins
transmembrane_region
TRANSMEM 1091..1111; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins