Taar4
entrez
209513
canonical
uniprot
Q5QD15
canonical
ensembl
ENSMUSG00000069707
resolver
ensp
ENSMUSP00000090330
resolver
enst
ENSMUST00000092660
resolver
genesymbol
Taar4
resolver
genesymbol_syn
Gm226
resolver
uniprot_entry
TAAR4_MOUSE
resolver
amino_acid_sequence
MNTPDPWSSPEVQFCFAAANSSCPRKARPALVVCAMYLIMIGAIVMTMLGNMAVIISIAHFKQLHSPTNFLILSMATTDFLLSCVVMPFSMIRSIESCWYFGDLFCKVHSCCDIMLCTTSIFHLCFISVDRHYAVCDPLHYVTQITTRVVGVFLLISWSVPIFFAFGLVFSELNLIGAEDFVAAIDCTGLCVLIFNKLWGVLASFIAFFLPGTVMVGIYIHIFTVAQKHARQIGTGPRTKQALSESKMKATSKKESKATKTLSIVMGVFVLCWLPFFVLTITDPFIDFTTPEDLYNVFLWLGYFNSTFNPIIYGMFYPWFRKALRMIVTGTIFRSDSSTSSLHPAHP
uniprot
proteins
function
FUNCTION: Olfactory receptor specific for 2-phenylethylamine, a trace amine present at high concentration in the urine of carnivore species, playing a key role in fear and avoidance responses (PubMed:16878137, PubMed:21690383, PubMed:22545963, PubMed:23624375, PubMed:30038239, PubMed:37225986). 2-phenylethylamine acts as a kairomone in the chemical detection of carnivore odor and triggers fear in mice (PubMed:16878137, PubMed:21690383, PubMed:23624375). This receptor is probably mediated by the G(s)-class of G proteins which activate adenylate cyclase (PubMed:16878137, PubMed:21690383, PubMed:23624375). {ECO:0000269|PubMed:16878137, ECO:0000269|PubMed:21690383, ECO:0000269|PubMed:22545963, ECO:0000269|PubMed:23624375, ECO:0000269|PubMed:30038239, ECO:0000269|PubMed:37225986}.
uniprot
proteins
mass_dalton
38904
uniprot
proteins
mutagenesis
MUTAGEN 23; /note="C->S: Decreased trace-amine receptor activity."; /evidence="ECO:0000269|PubMed:37225986"; MUTAGEN 113; /note="D->A: Abolished trace-amine receptor activity."; /evidence="ECO:0000269|PubMed:37225986"; MUTAGEN 117; /note="C->A: Does not affect trace-amine receptor activity."; /evidence="ECO:0000269|PubMed:37225986"; MUTAGEN 187; /note="C->S: Decreased trace-amine receptor activity."; /evidence="ECO:0000269|PubMed:37225986"; MUTAGEN 273; /note="W->A: Abolished trace-amine receptor activity."; /evidence="ECO:0000269|PubMed:37225986"; MUTAGEN 303; /note="Y->A: Abolished trace-amine receptor activity."; /evidence="ECO:0000269|PubMed:37225986
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15718104
uniprot
proteins
pubmed
16878137
uniprot
proteins
pubmed
21690383
uniprot
proteins
pubmed
22545963
uniprot
proteins
pubmed
22837392
uniprot
proteins
pubmed
23624375
uniprot
proteins
pubmed
30038239
uniprot
proteins
pubmed
37225986
uniprot
proteins
sequence_length
347
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 38..58; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 70..90; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 111..129; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 150..170; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 198..218; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 261..281; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 297..317; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins