POFUT4
entrez
170384
canonical
uniprot
Q495W5
canonical
ensembl
ENSG00000196968
resolver
ensp
ENSP00000361932
resolver
ensp
ENSP00000378270
resolver
ensp
ENSP00000680096
resolver
genesymbol
POFUT4
resolver
genesymbol_syn
FUT11
resolver
hgnc
HGNC:19233
resolver
uniprot
Q495W7
resolver
uniprot
Q8IYE4
resolver
uniprot_entry
OFUT4_HUMAN
resolver
uniprot_sec
Q495W7
resolver
uniprot_sec
Q8IYE4
resolver
amino_acid_sequence
MAAGPIRVVLVLLGVLSVCAASGHGSVAEREAGGEAEWAEPWDGAVFRPPSALGAVGVTRSSGTPRPGREEAGDLPVLLWWSPGLFPHFPGDSERIECARGACVASRNRRALRDSRTRALLFYGTDFRASAAPLPRLAHQSWALLHEESPLNNFLLSHGPGIRLFNLTSTFSRHSDYPLSLQWLPGTAYLRRPVPPPMERAEWRRRGYAPLLYLQSHCDVPADRDRYVRELMRHIPVDSYGKCLQNRELPTARLQDTATATTEDPELLAFLSRYKFHLALENAICNDYMTEKLWRPMHLGAVPVYRGSPSVRDWMPNNHSVILIDDFESPQKLAEFIDFLDKNDEEYMKYLAYKQPGGITNQFLLDSLKHREWGVNDPLLPNYLNGFECFVCDYELARLDAEKAHAASPGDSPVFEPHIAQPSHMDCPVPTPGFGNVEEIPENDSWKEMWLQDYWQGLDQGEALTAMIHNNETEQTKFWDYLHEIFMKRQHL
uniprot
proteins
ec_number
2.4.1.-
uniprot
proteins
ec_number
2.4.1.221
uniprot
proteins
function
FUNCTION: Protein O-fucosyltransferase that specifically catalyzes O-fucosylation of serine or threonine residues in EMI domains of target proteins, such as MMRN1, MMRN2 and EMID1 (PubMed:39775168). Attaches fucose through an O-glycosidic linkage (PubMed:39775168). O-fucosylation of EMI domain-containing proteins may be required for facilitating protein folding and secretion (PubMed:39775168). Also shows minor alpha-(1,3)-fucosyltransferase activity toward activity toward biantennary N-glycan acceptors (PubMed:19088067). However, this was tested with a library of synthetic substrates and this activity is unsure in vivo (PubMed:19088067). {ECO:0000269|PubMed:19088067, ECO:0000269|PubMed:39775168}.
uniprot
proteins
mass_dalton
55816
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:39775168, ECO:0000305|PubMed:19088067}.
uniprot
proteins
protein_family
Glycosyltransferase 10 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19088067
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
39775168
uniprot
proteins
sequence_length
492
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:39775168}; Single-pass type II membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..24; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins