HROB
entrez
78995
canonical
uniprot
Q8N3J3
canonical
ensembl
ENSG00000125319
resolver
ensp
ENSP00000245382
resolver
ensp
ENSP00000313500
resolver
ensp
ENSP00000466618
resolver
ensp
ENSP00000580180
resolver
ensp
ENSP00000580181
resolver
ensp
ENSP00000580182
resolver
ensp
ENSP00000580183
resolver
ensp
ENSP00000604792
resolver
ensp
ENSP00000604793
resolver
ensp
ENSP00000604794
resolver
ensp
ENSP00000604796
resolver
ensp
ENSP00000604797
resolver
ensp
ENSP00000604798
resolver
ensp
ENSP00000604799
resolver
ensp
ENSP00000604800
resolver
ensp
ENSP00000604804
resolver
ensp
ENSP00000604805
resolver
ensp
ENSP00000604808
resolver
ensp
ENSP00000604810
resolver
ensp
ENSP00000667119
resolver
ensp
ENSP00000682349
resolver
ensp
ENSP00000730537
resolver
ensp
ENSP00000730538
resolver
ensp
ENSP00000730540
resolver
ensp
ENSP00000730541
resolver
genesymbol
HROB
resolver
genesymbol_syn
C17orf53
resolver
hgnc
HGNC:28460
resolver
uniprot
A8K7A9
resolver
uniprot
Q9BWM9
resolver
uniprot
Q9HAI1
resolver
uniprot_entry
HROB_HUMAN
resolver
uniprot_sec
A8K7A9
resolver
uniprot_sec
Q9BWM9
resolver
uniprot_sec
Q9HAI1
resolver
amino_acid_sequence
MACSLQKLFAVEEEFEDEDFLSAVEDAENRFTGSLPVNAGRLRPVSSRPQETVQAQSSRLLLLHPTAPSEALGLPDLDLCLPASSTPSADSRPSCIGAAPLRPVSTSSSWIGNQRRVTVTEVLRETARPQSSALHPLLTFESQQQQVGGFEGPEQDEFDKVLASMELEEPGMELECGVSSEAIPILPAQQREGSVLAKKARVVDLSGSCQKGPVPAIHKAGIMSAQDESLDPVIQCRTPRPPLRPGAVGHLPVPTALTVPTQQLHWEVCPQRSPVQALQPLQAARGTIQSSPQNRFPCQPFQSPSSWLSGKAHLPRPRTPNSSCSTPSRTSSGLFPRIPLQPQAPVSSIGSPVGTPKGPQGALQTPIVTNHLVQLVTAASRTPQQPTHPSTRAKTRRFPGPAGILPHQQSGRSLEDIMVSAPQTPTHGALAKFQTEIVASSQASVEEDFGRGPWLTMKSTLGLDERDPSCFLCTYSIVMVLRKQAALKQLPRNKVPNMAVMIKSLTRSTMDASVVFKDPTGEMQGTVHRLLLETCQNELKPGSVLLLKQIGVFSPSLRNHYLNVTPNNLVHIYSPDSGDGSFLKPSQPFPKDSGSFQHDVAAKPEEGFRTAQNLEAEASPEEELPEADDLDGLLSELPEDFFCGTSS
uniprot
proteins
disease_involvement
DISEASE: Ovarian dysgenesis 11 (ODG11) [MIM:620897]: An autosomal recessive form of ovarian dysgenesis, a disorder characterized by lack of spontaneous pubertal development, primary amenorrhea, uterine hypoplasia, and hypergonadotropic hypogonadism as a result of streak gonads. {ECO:0000269|PubMed:34707299, ECO:0000269|PubMed:38105698}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: DNA-binding protein involved in homologous recombination that acts by recruiting the MCM8-MCM9 helicase complex to sites of DNA damage to promote DNA repair synthesis (PubMed:31467087). A C-terminal region including the OB-fold stimulates the helicase activity of MCM8-MCM9 probably by altering its conformation (PubMed:37535404). {ECO:0000269|PubMed:31467087, ECO:0000269|PubMed:37535404}.
uniprot
proteins
mass_dalton
69771
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
31467087
uniprot
proteins
pubmed
34707299
uniprot
proteins
pubmed
37535404
uniprot
proteins
pubmed
38105698
uniprot
proteins
sequence_length
647
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31467087}. Chromosome {ECO:0000269|PubMed:31467087}. Note=Localized to the sites of DNA damage. {ECO:0000269|PubMed:31467087}.
uniprot
proteins