Rtel1
entrez
269400
canonical
uniprot
Q0VGM9
canonical
ensembl
ENSMUSG00000038685
resolver
ensp
ENSMUSP00000043563
resolver
ensp
ENSMUSP00000053120
resolver
ensp
ENSMUSP00000096571
resolver
ensp
ENSMUSP00000104442
resolver
ensp
ENSMUSP00000104443
resolver
ensp
ENSMUSP00000176875
resolver
genesymbol
Rtel1
resolver
genesymbol_syn
Kiaa1088
resolver
genesymbol_syn
Rtel
resolver
uniprot
A2AU09
resolver
uniprot
A2AU10
resolver
uniprot
A2AU11
resolver
uniprot
A2AU12
resolver
uniprot
A2AU13
resolver
uniprot
A2AU14
resolver
uniprot
Q3UM40
resolver
uniprot
Q5F0J8
resolver
uniprot
Q69ZS1
resolver
uniprot
Q6H1L0
resolver
uniprot
Q6H1L1
resolver
uniprot
Q6H1L2
resolver
uniprot
Q6H1L3
resolver
uniprot_entry
RTEL1_MOUSE
resolver
uniprot_sec
A2AU09
resolver
uniprot_sec
A2AU10
resolver
uniprot_sec
A2AU11
resolver
uniprot_sec
A2AU12
resolver
uniprot_sec
A2AU13
resolver
uniprot_sec
A2AU14
resolver
uniprot_sec
Q3UM40
resolver
uniprot_sec
Q5F0J8
resolver
uniprot_sec
Q69ZS1
resolver
uniprot_sec
Q6H1L0
resolver
uniprot_sec
Q6H1L1
resolver
uniprot_sec
Q6H1L2
resolver
uniprot_sec
Q6H1L3
resolver
amino_acid_sequence
MPRVVLNGVTVDFPFQPYPCQQEYMTKVLECLQKKVNGILESPTGTGKTLCLLCSTLAWQQHLRDAVSSLKIAERVQGELFASRTLSSWGSAAAASGDSIECYTDIPKIIYASRTHSQLTQVIRELRNTAYRPKVCVLGSREQLCIHPEVKKQESNHMQISLCRKKVASRSCHFYNNVEAKFLEQDLATPILDIEDLVKNGSKQKMCPYYLSRNMKQQADIIFMPYNYLLDAKSRKAHSIDLKGTVVIFDEAHNVEKICEESASFDLTPRDVASGLEIINQVLEEQARVTQQGELQQEFIVDTSSSGLNMELEDIAKLKMILLRLEEAIDAVQLPGDDRGVTKPGSYIFELFAEAQITFQTKGCILESLDQIIQHLAGRTGVFTNTAGLQKLMDIIQIVFSVDPPEGSPGSLVGLGISHSYKVHIHPETSHRRAAKRSDAWSTTASRKQGKVLSYWCFSPSQSMRELVCQGVRTLILTSGTLAPLSSFALEMQIPFPVCLENPHIIDKNQLWVGIVPRGPDGVQLSSAYDKRFSEECLSSLGKALSNIARVVPHGLLVFFPSYPVMEKSLEFWQVQGLARKVEALKPLFVEPRNKGSFSEVIDAYYQQVASPASNGATFLAVCRGKASEGLDFSDMNGRGVIVTGLPYPPRMDPRVVLKMQFLDEMRGRSGVGGQCLSGQEWYQQQASRAVNQAIGRVIRHRHDYGAIFLCDHRFAYADARAQLPSWVRPYLKVYDNFGHVIRDVAQFFRVAQKTMPLPVPQAVTSSVSEGEIALKDATLSSYSLSTRKAMSLDVHVPSLRQKPIGLPAAGDSESSLCGEYEQQTFSAQQRPMGLLAALEYNEQKAGASEEQALGSSTPSLRCEKRLSTEQKGGRKKVRLVNHPEEPMAGTQAGRAKMFMVAVKQALSQANFDTFTQALQHYKSSDDFEALVASLTCLFAEDPKKHTLLKGFYQFVRPHHKQQFEDICFQLTGQRCGYQPGKRELESKLTLSEGVDRQLDPGQHLNQGQPHLSAHPTSKGHTSHCTKVGCAVEKPGQPAVSDYLSDVHKALGSASCNQLTAALRAYKQDDDLDKVVAVVAALTTAKPEHLPLLQRFGMFVRRHHKPQFLQTCADLMGLPTTGKDLELEGPRDESPTVPPELTHEDLKPGPSMSKKPEKTQSKISSFFRQRPDESVRSDDTTPKPMQLPPRLPHELMKPHRSKQ
uniprot
proteins
ec_number
5.6.2.-
uniprot
proteins
function
FUNCTION: A probable ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere (PubMed:22579284). {ECO:0000255|HAMAP-Rule:MF_03065, ECO:0000269|PubMed:15210109, ECO:0000269|PubMed:22579284, ECO:0000269|PubMed:22593209, ECO:0000269|PubMed:24115439}.
uniprot
proteins
mass_dalton
133767
uniprot
proteins
mutagenesis
MUTAGEN 48; /note="K->R: Abolishes G4-DNA unwinding activity."; /evidence="ECO:0000269|PubMed:24115439"; MUTAGEN 1160; /note="Q->A: Abolishes interaction with PCNA."; /evidence="ECO:0000269|PubMed:24115439"; MUTAGEN 1163; /note="I->A: Abolishes interaction with PCNA."; /evidence="ECO:0000269|PubMed:24115439"; MUTAGEN 1166; /note="F->A: Abolishes interaction with PCNA."; /evidence="ECO:0000269|PubMed:24115439"; MUTAGEN 1167; /note="F->A: Abolishes interaction with PCNA."; /evidence="ECO:0000269|PubMed:24115439
uniprot
proteins
protein_family
Helicase family
uniprot
proteins
protein_family
RAD3/XPD subfamily
uniprot
proteins
pubmed
15210109
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18064678
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22579284
uniprot
proteins
pubmed
22593209
uniprot
proteins
pubmed
24115439
uniprot
proteins
pubmed
9671732
uniprot
proteins
sequence_length
1203
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03065, ECO:0000269|PubMed:15210109, ECO:0000269|PubMed:24115439}. Note=Colocalizes with PCNA within the replication foci in S-phase cells.
uniprot
proteins