HAS3
entrez
3038
canonical
uniprot
O00219
canonical
ensembl
ENSG00000103044
resolver
ensp
ENSP00000219322
resolver
ensp
ENSP00000304440
resolver
ensp
ENSP00000454731
resolver
ensp
ENSP00000521878
resolver
ensp
ENSP00000521879
resolver
genesymbol
HAS3
resolver
hgnc
HGNC:4820
resolver
uniprot
A8K5T5
resolver
uniprot
Q8WTZ0
resolver
uniprot
Q96RV2
resolver
uniprot
Q9NYP0
resolver
uniprot_entry
HYAS3_HUMAN
resolver
uniprot_entry
Q96RV2_HUMAN
resolver
uniprot_sec
A8K5T5
resolver
uniprot_sec
Q8WTZ0
resolver
uniprot_sec
Q9NYP0
resolver
activity_regulation
ACTIVITY REGULATION: The enzymatic activity depends on the availability of cytosolic levels of UDP-GlcUA and UDP-GlcNAc. {ECO:0000269|PubMed:23303191, ECO:0000269|PubMed:26883802}.
uniprot
proteins
amino_acid_sequence
MPVQLTTALRVVGTSLFALAVLGGILAAYVTGYQFIHTEKHYLSFGLYGAILGLHLLIQSLFAFLEHRRMRRAGQALKLPSPRRGSVALCIAAYQEDPDYLRKCLRSAQRISFPDLKVVMVVDGNRQEDAYMLDIFHEVLGGTEQAGFFVWRSNFHEAGEGETEASLQEGMDRVRDVVRASTFSCIMQKWGGKREVMYTAFKALGDSVDYIQVCDSDTVLDPACTIEMLRVLEEDPQVGGVGGDVQILNKYDSWISFLSSVRYWMAFNVERACQSYFGCVQCISGPLGMYRNSLLQQFLEDWYHQKFLGSKCSFGDDRHLTNRVLSLGYRTKYTARSKCLTETPTKYLRWLNQQTRWSKSYFREWLYNSLWFHKHHLWMTYESVVTGFFPFFLIATVIQLFYRGRIWNILLFLLTVQLVGIIKATYACFLRGNAEMIFMSLYSLLYMSSLLPAKIFAIATINKSGWGTSGRKTIVVNFIGLIPVSIWVAVLLGGLAYTAYCQDLFSETELAFLVSGAILYGCYWVALLMLYLAIIARRCGKKPEQYSLAFAEV
uniprot
proteins
ec_number
2.4.1.212
uniprot
proteins
function
FUNCTION: Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of three isoenzymes responsible for cellular hyaluronan synthesis. {ECO:0000269|PubMed:23303191, ECO:0000269|PubMed:25795779, ECO:0000269|PubMed:26883802}.
uniprot
proteins
mass_dalton
62998
uniprot
proteins
pathway_participation
PATHWAY: Glycan biosynthesis; hyaluronan biosynthesis. {ECO:0000269|PubMed:23303191}.
uniprot
proteins
post_translational_modification
PTM: O-GlcNAcylation increases the hyaluronan synthase activity, HAS3 stability and its plasma membrane residence. The concentration of UDP-GlcNAc controls the level of O-GlcNAc modification. {ECO:0000269|PubMed:26883802}.
uniprot
proteins
protein_family
NodC/HAS family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
23303191
uniprot
proteins
pubmed
25795779
uniprot
proteins
pubmed
26883802
uniprot
proteins
pubmed
30394292
uniprot
proteins
pubmed
9083017
uniprot
proteins
sequence_length
553
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25795779, ECO:0000269|PubMed:26883802, ECO:0000269|PubMed:30394292}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:25795779}; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:O08650}; Multi-pass membrane protein {ECO:0000255}. Early endosome {ECO:0000269|PubMed:26883802}. Note=Travels from endoplasmic reticulum (ER), Golgi to plasma membrane (PubMed:26883802). Active only when present in plasma membrane (By similarity). O-GlcNAcylation controls its membrane localization (PubMed:26883802). A rapid recycling of HAS3 between plasma membrane and endosomes is controlled by the cytosolic levels of UDP-GlcUA and UDP-GlcNAc (PubMed:26883802). {ECO:0000250|UniProtKB:O08650, ECO:0000269|PubMed:26883802}.
uniprot
proteins
transmembrane_region
TRANSMEM 16..36; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 45..65; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 378..398; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 409..429; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 441..461; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 474..494; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 516..536; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins