Igf2
entrez
16002
canonical
uniprot
P09535
canonical
ensembl
ENSMUSG00000048583
resolver
ensp
ENSMUSP00000000033
resolver
ensp
ENSMUSP00000101555
resolver
ensp
ENSMUSP00000101556
resolver
ensp
ENSMUSP00000114076
resolver
ensp
ENSMUSP00000362048
resolver
genesymbol
Igf2
resolver
genesymbol_syn
Igf-2
resolver
uniprot
E9QLW5
resolver
uniprot_entry
IGF2_MOUSE
resolver
uniprot_sec
E9QLW5
resolver
amino_acid_sequence
MGIPVGKSMLVLLISLAFALCCIAAYGPGETLCGGELVDTLQFVCSDRGFYFSRPSSRANRRSRGIVEECCFRSCDLALLETYCATPAKSERDVSTSQAVLPDDFPRYPVGKFFQYDTWRQSAGRLRRGLPALLRARRGRMLAKELKEFREAKRHRPLIVLPPKDPAHGGASSEMSSNHQ
uniprot
proteins
function
FUNCTION: The insulin-like growth factors possess growth-promoting activity (PubMed:29440408). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development (Probable) (PubMed:12087403, PubMed:2330056). IGF2 is influenced by placental lactogen (Probable). Also involved in tissue differentiation (Probable). In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (By similarity). Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (PubMed:16901893). Inhibits myoblast differentiation and modulates metabolism via increasing the mitochondrial respiration rate (PubMed:32557799). {ECO:0000250|UniProtKB:P01344, ECO:0000269|PubMed:12087403, ECO:0000269|PubMed:16901893, ECO:0000269|PubMed:2330056, ECO:0000269|PubMed:29440408, ECO:0000269|PubMed:32557799, ECO:0000305|PubMed:24593700, ECO:0000305|PubMed:28522536}.; FUNCTION: Preptin undergoes glucose-mediated co-secretion with insulin, and acts as a physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3. {ECO:0000269|PubMed:16912056}.
uniprot
proteins
mass_dalton
20030
uniprot
proteins
post_translational_modification
PTM: Proteolytically processed by PCSK4, proIGF2 is cleaved at Arg-128 and Arg-92 to generate big-IGF2 and mature IGF2. {ECO:0000250|UniProtKB:P01344}.
uniprot
proteins
protein_family
Insulin family
uniprot
proteins
pubmed
11716772
uniprot
proteins
pubmed
12087403
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16901893
uniprot
proteins
pubmed
16912056
uniprot
proteins
pubmed
1702294
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19706595
uniprot
proteins
pubmed
1997210
uniprot
proteins
pubmed
2330056
uniprot
proteins
pubmed
24593700
uniprot
proteins
pubmed
2537977
uniprot
proteins
pubmed
28522536
uniprot
proteins
pubmed
29440408
uniprot
proteins
pubmed
32557799
uniprot
proteins
pubmed
3780370
uniprot
proteins
pubmed
8265819
uniprot
proteins
pubmed
9039503
uniprot
proteins
sequence_length
180
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:28522536}.
uniprot
proteins