Klhl6
entrez
239743
canonical
uniprot
Q6V595
canonical
ensembl
ENSMUSG00000043008
resolver
ensp
ENSMUSP00000053023
resolver
ensp
ENSMUSP00000245163
resolver
ensp
ENSMUSP00000245168
resolver
enst
ENSMUST00000058839
resolver
genesymbol
Klhl6
resolver
uniprot
Q497G3
resolver
uniprot_entry
KLHL6_MOUSE
resolver
uniprot_sec
Q497G3
resolver
amino_acid_sequence
MAGQRGACTMSDVVERSLEGPLALTTDKSSQKRGDLVEILTGEKVKFDDTRLSLILQNGLETLREENALTDVILCVDVQEFSCHRVVLAAASNYFRAMFCNDLKEKYEKRIIIKGVDAETMHTLLVYTYTSKALITKQNVQRVLEAANLFQFLQLVDACASFLTEALNPENCIGILRLADTHSLDSLKMQVQSYIIQNFVQILNSEEFLELPVDTLYHILRSDDLCVTEEAQVFETVMSWVRHKQSERLCLLPCVLENVRLPLLDPWYFVEMVEADPLIRQCPEVFPLLQEARMYHLSGNEIISERTKPRMHEFQSEVFMIIGGCTKDERFVAEVTCLDPLRRSRLEVAKLPLTEHELESENKKWVEFACVTLKNEVYISGGKETQHDVWKYNSSINKWIQIEYLNIGRWRHKMVVLGGKVYVLGGFDGLQRINNVETYDPFHNCWSEAAPLHVHVSSFAATSHKKKLYVIGGGPNGKLATDKTQCYDPSTNKWVLKSAMPVEAKCINAVSFQDHIYVVGGAMRALYAYSPLEDSWCLVTQLSHERASCGIAPCNNKLYITGGRDEKNEVIATVLCWDPEAQKLTEECVLPRGVSHHGSVTIRKSYTHIRRVVPGAVSV
uniprot
proteins
function
FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a multifunctional regulator of B-cell receptor (BCR) signaling, germinal center formation, and T-cell function (PubMed:16166635). Functions by mediating polyubiquitination of target proteins, leading to their proteasomal degradation. In B-cells, plays an essential role in BCR signaling and germinal center B-cell maturation. Targets the BCR signaling subunits CD79A and CD79B for ubiquitin-mediated degradation, thereby controlling surface BCR homeostasis. Mediates polyubiquitination and degradation of the mRNA decay factor roquin-2/RC3H2, which in turn allows accumulation of TNFAIP3, a negative regulator of NF-kappa-B signaling, thereby providing feedback inhibition of BCR-induced NF-kappa-B activation. In T-cells, acts as a dual negative regulator of T-cell exhaustion and mitochondrial dysfunction. Promotes 'Lys-48'-linked polyubiquitination and proteasomal degradation of the transcription factor TOX, thereby attenuating the transition of progenitor exhausted T-cells towards terminal exhaustion. Also targets the mitochondrial phosphatase PGAM5 for degradation, thereby preventing excessive PGAM5-mediated dephosphorylation and activation of DRP1, which would otherwise drive pathological mitochondrial fission. Through these mechanisms, maintains mitochondrial fitness in T-cells during chronic antigen stimulation. {ECO:0000250|UniProtKB:Q8WZ60, ECO:0000269|PubMed:16166635}.
uniprot
proteins
mass_dalton
70191
uniprot
proteins
pubmed
12617994
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16166635
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
619
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8WZ60}.
uniprot
proteins