Nus1
entrez
52014
canonical
uniprot
Q99LJ8
canonical
ensembl
ENSMUSG00000023068
resolver
ensp
ENSMUSP00000023830
resolver
enst
ENSMUST00000023830
resolver
genesymbol
Nus1
resolver
genesymbol_syn
D10Ertd438e
resolver
genesymbol_syn
Ngbr
resolver
uniprot
Q0P6D7
resolver
uniprot
Q3TIA3
resolver
uniprot
Q3TIR7
resolver
uniprot
Q3U1Z4
resolver
uniprot_entry
NGBR_MOUSE
resolver
uniprot_sec
Q0P6D7
resolver
uniprot_sec
Q3TIA3
resolver
uniprot_sec
Q3TIR7
resolver
uniprot_sec
Q3U1Z4
resolver
amino_acid_sequence
MTGLYELVWRVLHALLCLHLTLTSWLRVRFGTWNWIWRRCCRAASAAVLAPLGFTLRKPRAVGRNRRHHRHPHGGPGPGPGPAATHPRLRWRADVRSLQKLPVHMGLLVTEEVQEPSFSDIASLVVWCMAVGISYISVYDHQGIFKRNNSRLMDEILKQQQELLGQDCSKYSAEFANSNDKDDQDLNCPSAVKVLSPEDGKADIVRAAQDFCQLVAQQQRKPTDLDVDLLGSLLSSHGFPDPDLVLKFGPVDSTLGFLPWQIRLTEIVSLPSHLNISYEDFFSALRQYAACEQRLGK
uniprot
proteins
ec_number
2.5.1.87
uniprot
proteins
function
FUNCTION: With DHDDS, forms the dehydrodolichyl diphosphate synthase (DDS) complex, an essential component of the dolichol monophosphate (Dol-P) biosynthetic machinery (PubMed:25066056). Both subunits contribute to enzymatic activity, i.e. condensation of multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP), a precursor of dolichol phosphate which is utilized as a sugar carrier in protein glycosylation in the endoplasmic reticulum (ER) (By similarity). Synthesizes long-chain polyprenols, mostly of C95 and C100 chain length (By similarity). Regulates the glycosylation and stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol (By similarity). Acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator (By similarity). {ECO:0000250|UniProtKB:Q96E22, ECO:0000269|PubMed:25066056}.
uniprot
proteins
mass_dalton
33485
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:Q96E22}.; PATHWAY: Lipid metabolism. {ECO:0000250|UniProtKB:Q96E22}.
uniprot
proteins
protein_family
UPP synthase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16835300
uniprot
proteins
pubmed
25066056
uniprot
proteins
pubmed
26755743
uniprot
proteins
sequence_length
297
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q96E22}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96E22}. Note=Colocalizes with Nogo-B during VEGF and wound healing angiogenesis. {ECO:0000250|UniProtKB:Q96E22}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..26; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q96E22"; TRANSMEM 40..56; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q96E22"; TRANSMEM 121..139; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q96E22
uniprot
proteins