PAK4
entrez
10298
canonical
uniprot
O96013
canonical
ensembl
ENSG00000130669
resolver
ensp
ENSP00000351049
resolver
ensp
ENSP00000353625
resolver
ensp
ENSP00000469413
resolver
ensp
ENSP00000470284
resolver
ensp
ENSP00000471157
resolver
ensp
ENSP00000566150
resolver
ensp
ENSP00000566155
resolver
ensp
ENSP00000566160
resolver
ensp
ENSP00000566170
resolver
ensp
ENSP00000566171
resolver
ensp
ENSP00000566175
resolver
ensp
ENSP00000566176
resolver
ensp
ENSP00000566179
resolver
ensp
ENSP00000566182
resolver
genesymbol
PAK4
resolver
genesymbol_syn
KIAA1142
resolver
hgnc
HGNC:16059
resolver
uniprot
B4DGG6
resolver
uniprot
Q8N4E1
resolver
uniprot
Q8NCH5
resolver
uniprot
Q8NDE3
resolver
uniprot
Q9BU33
resolver
uniprot
Q9ULS8
resolver
uniprot_entry
PAK4_HUMAN
resolver
uniprot_sec
B4DGG6
resolver
uniprot_sec
Q8N4E1
resolver
uniprot_sec
Q8NCH5
resolver
uniprot_sec
Q8NDE3
resolver
uniprot_sec
Q9BU33
resolver
uniprot_sec
Q9ULS8
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by INKA1; which inhibits the serine/threonine-protein kinase activity by binding PAK4 in a substrate-like manner (PubMed:26607847). {ECO:0000269|PubMed:26607847}.
uniprot
proteins
amino_acid_sequence
MFGKRKKRVEISAPSNFEHRVHTGFDQHEQKFTGLPRQWQSLIEESARRPKPLVDPACITSIQPGAPKTIVRGSKGAKDGALTLLLDEFENMSVTRSNSLRRDSPPPPARARQENGMPEEPATTARGGPGKAGSRGRFAGHSEAGGGSGDRRRAGPEKRPKSSREGSGGPQESSRDKRPLSGPDVGTPQPAGLASGAKLAAGRPFNTYPRADTDHPSRGAQGEPHDVAPNGPSAGGLAIPQSSSSSSRPPTRARGAPSPGVLGPHASEPQLAPPACTPAAPAVPGPPGPRSPQREPQRVSHEQFRAALQLVVDPGDPRSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQRRELLFNEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIAAVCLAVLQALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPELISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPRLKNLHKVSPSLKGFLDRLLVRDPAQRATAAELLKHPFLAKAGPPASIVPLMRQNRTR
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell adhesion turnover, cell migration, growth, proliferation or cell survival (PubMed:26598620). Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates and inactivates the protein phosphatase SSH1, leading to increased inhibitory phosphorylation of the actin binding/depolymerizing factor cofilin. Decreased cofilin activity may lead to stabilization of actin filaments. Phosphorylates LIMK1, a kinase that also inhibits the activity of cofilin. Phosphorylates integrin beta5/ITGB5 and thus regulates cell motility. Phosphorylates ARHGEF2 and activates the downstream target RHOA that plays a role in the regulation of assembly of focal adhesions and actin stress fibers. Stimulates cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Alternatively, inhibits apoptosis by preventing caspase-8 binding to death domain receptors in a kinase independent manner. Plays a role in cell-cycle progression by controlling levels of the cell-cycle regulatory protein CDKN1A and by phosphorylating RAN. Promotes kinase-independent stabilization of RHOU, thereby contributing to focal adhesion disassembly during cell migration (PubMed:26598620). {ECO:0000269|PubMed:11278822, ECO:0000269|PubMed:11313478, ECO:0000269|PubMed:14560027, ECO:0000269|PubMed:15660133, ECO:0000269|PubMed:20507994, ECO:0000269|PubMed:20631255, ECO:0000269|PubMed:20805321, ECO:0000269|PubMed:26598620, ECO:0000269|PubMed:26607847}.
uniprot
proteins
mass_dalton
64072
uniprot
proteins
mutagenesis
MUTAGEN 19; /note="H->L: No change in cell motility; in association with L-22."; /evidence="ECO:0000269|PubMed:26598620"; MUTAGEN 22; /note="H->L: No change in cell motility; in association with L-19."; /evidence="ECO:0000269|PubMed:26598620"; MUTAGEN 350; /note="K->M: No change in cell motility; in association with M-351."; /evidence="ECO:0000269|PubMed:26598620"; MUTAGEN 351; /note="K->M: No change in cell motility; in association with M-350."; /evidence="ECO:0000269|PubMed:26598620"; MUTAGEN 445; /note="S->N: Approximately 30-fold increased autophosphorylation (constitutively active mutant)."; /evidence="ECO:0000269|PubMed:11313478"; MUTAGEN 474; /note="S->E: Approximately 3-fold increased autophosphorylation."; /evidence="ECO:0000269|PubMed:11313478
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated on serine residues when activated by CDC42/p21 (Ref.33). Phosphorylated on tyrosine residues upon stimulation of FGFR2 (By similarity). Methylated by SETD6. {ECO:0000250|UniProtKB:Q8BTW9, ECO:0000269|PubMed:30189201, ECO:0000269|Ref.33}.; PTM: Polyubiquitinated, leading to its proteasomal degradation. {ECO:0000269|PubMed:24130170}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
protein_family
STE20 subfamily
uniprot
proteins
pubmed
10574461
uniprot
proteins
pubmed
11278822
uniprot
proteins
pubmed
11313478
uniprot
proteins
pubmed
11950587
uniprot
proteins
pubmed
12356872
uniprot
proteins
pubmed
14560027
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15660133
uniprot
proteins
pubmed
15827085
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20070256
uniprot
proteins
pubmed
20507994
uniprot
proteins
pubmed
20631255
uniprot
proteins
pubmed
20805321
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24130170
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26598620
uniprot
proteins
pubmed
26607847
uniprot
proteins
pubmed
30189201
uniprot
proteins
pubmed
9822598
uniprot
proteins
sequence_length
591
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12356872, ECO:0000269|PubMed:26598620}. Note=Seems to shuttle between cytoplasmic compartments depending on the activating effector. For example, can be found on the cell periphery after activation of growth-factor or integrin-mediated signaling pathways. {ECO:0000269|PubMed:12356872}.
uniprot
proteins