Klra3
entrez
16634
canonical
uniprot
Q64329
canonical
ensembl
ENSMUSG00000067591
resolver
ensp
ENSMUSP00000085333
resolver
ensp
ENSMUSP00000107629
resolver
ensp
ENSMUSP00000365204
resolver
enst
ENSMUST00000088017
resolver
enst
ENSMUST00000111998
resolver
genesymbol
Klra3
resolver
genesymbol_syn
Ly-49c
resolver
genesymbol_syn
Ly49C
resolver
uniprot
Q3TWQ1
resolver
uniprot
Q3ZB40
resolver
uniprot
Q499I4
resolver
uniprot
Q61154
resolver
uniprot
Q61198
resolver
uniprot
Q64257
resolver
uniprot_entry
KLRA3_MOUSE
resolver
uniprot_sec
Q3TWQ1
resolver
uniprot_sec
Q3ZB40
resolver
uniprot_sec
Q499I4
resolver
uniprot_sec
Q61154
resolver
uniprot_sec
Q61198
resolver
uniprot_sec
Q64257
resolver
amino_acid_sequence
MSEPEVTYSTVRLHKSSGLQKLVRHEETQGPREVGNRKCSAPWQLIVKALGILCFLLLVTVAVLAVKIFQYNQHKQEINETLNHHHNCSNMQRAFNLKEEMLTNKSIDCRPSNETLEYIKREQDRWDSKTKTVLDSSRDTGRGVKYWFCYSTKCYYFIMNKTTWSGCKANCQHYSVPILKIEDEDELKFLQRHVIPENYWIGLSYDKKKKEWAWIDNGPSKLDMKIRKMNFKSRGCVFLSKARIEDIDCNIPYYCICGKKLDKFPD
uniprot
proteins
function
FUNCTION: Receptor on natural killer (NK) cells for class I MHC. {ECO:0000269|PubMed:8976165}.
uniprot
proteins
mass_dalton
31311
uniprot
proteins
mutagenesis
MUTAGEN 121; /note="R->G: Increases stability and improves binding to MHCI class ligand; when associated with G-175; G-197 and K-227."; /evidence="ECO:0000269|PubMed:14595439"; MUTAGEN 160; /note="N->D: Greatly reduces MHC class I peptide tetramer binding; when associated with L-162."; /evidence="ECO:0000269|PubMed:11777974"; MUTAGEN 161; /note="K->R: No effect on MHC class I peptide tetramer binding."; /evidence="ECO:0000269|PubMed:11777974"; MUTAGEN 162; /note="T->K: Greatly reduces MHC class I peptide tetramer binding; when associated with D-160."; /evidence="ECO:0000269|PubMed:11777974"; MUTAGEN 169; /note="A->Q: No effect on MHC class I peptide tetramer binding; when associated with T-170."; /evidence="ECO:0000269|PubMed:11777974"; MUTAGEN 170; /note="N->T: No effect on MHC class I peptide tetramer binding; when associated with Q-169."; /evidence="ECO:0000269|PubMed:11777974"; MUTAGEN 173; /note="H->S: No effect on MHC class I peptide tetramer binding; when associated with S-174."; /evidence="ECO:0000269|PubMed:11777974"; MUTAGEN 174; /note="Y->S: No effect on MHC class I binding; when associated with S-173."; /evidence="ECO:0000269|PubMed:11777974"; MUTAGEN 175; /note="S->G: Increases stability. Increases stability and improves binding to MHCI class ligand; when associated with G-121; G-197 and K-227."; /evidence="ECO:0000269|PubMed:14595439"; MUTAGEN 195; /note="I->P: Greatly reduces MHC class I peptide tetramer binding; when associated with S-196."; /evidence="ECO:0000269|PubMed:11777974"; MUTAGEN 196; /note="P->S: Greatly reduces MHC class I peptide tetramer binding; when associated with P-195."; /evidence="ECO:0000269|PubMed:11777974"; MUTAGEN 197; /note="E->G: Increases stability and improves binding to MHCI class ligand; when associated with G-121; G-175 and K-227."; /evidence="ECO:0000269|PubMed:14595439"; MUTAGEN 225; /note="K->N: Greatly reduces MHC class I peptide tetramer binding; when associated with T-226."; /evidence="ECO:0000269|PubMed:11777974"; MUTAGEN 226; /note="I->T: Greatly reduces MHC class I peptide tetramer binding; when associated with N-225."; /evidence="ECO:0000269|PubMed:11777974"; MUTAGEN 227; /note="R->K: Increases stability and improves binding to MHCI class ligand; when associated with G-121; G-175 and G-197."; /evidence="ECO:0000269|PubMed:14595439"; MUTAGEN 234; /note="R->G: No effect on MHC class I peptide tetramer binding."; /evidence="ECO:0000269|PubMed:11777974"; MUTAGEN 248; /note="D->N: No effect on MHC class I peptide tetramer binding; when associated with D-250."; /evidence="ECO:0000269|PubMed:11777974"; MUTAGEN 250; /note="N->D: No effect on MHC class I peptide tetramer binding; when associated with N-248."; /evidence="ECO:0000269|PubMed:11777974"; MUTAGEN 251; /note="I->Q: No effect on MHC class I peptide tetramer binding."; /evidence="ECO:0000269|PubMed:11777974
uniprot
proteins
pubmed
11777974
uniprot
proteins
pubmed
14595439
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18426793
uniprot
proteins
pubmed
1869832
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23666294
uniprot
proteins
pubmed
27385590
uniprot
proteins
pubmed
7629496
uniprot
proteins
pubmed
8892625
uniprot
proteins
pubmed
8976165
uniprot
proteins
sequence_length
266
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 49..69; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins