ACTMAP
entrez
284325
canonical
uniprot
Q5BKX5
canonical
ensembl
ENSG00000188493
resolver
ensp
ENSP00000367564
resolver
ensp
ENSP00000652244
resolver
ensp
ENSP00000652245
resolver
ensp
ENSP00000652247
resolver
ensp
ENSP00000652248
resolver
genesymbol
ACTMAP
resolver
genesymbol_syn
C19orf54
resolver
hgnc
HGNC:24758
resolver
uniprot
A8MSZ5
resolver
uniprot
B4DNU7
resolver
uniprot_entry
ACTMP_HUMAN
resolver
uniprot_sec
A8MSZ5
resolver
uniprot_sec
B4DNU7
resolver
amino_acid_sequence
MTSPCSPPLKPPISPPKTPVPQASSIPSPPLPPSPLDFSALPSPPWSQQTPVPPPLPLPPPPAATGPAPRHVFGLEKSQLLKEAFDKAGPVPKGREDVKRLLKLHKDRFRGDLRWILFCADLPSLIQEGPQCGLVALWMAGTLLSPPSGVPLERLIRVATERGYTAQGEMFSVADMGRLAQEVLGCQAKLLSGGLGGPNRDLVLQHLVTGHPLLIPYDEDFNHEPCQRKGHKAHWAVSAGVLLGVRAVPSLGYTEDPELPGLFHPVLGTPCQPPSLPEEGSPGAVYLLSKQGKSWHYQLWDYDQVRESNLQLTDFSPSRATDGRVYVVPVGGVRAGLCGQALLLTPQDCSH
uniprot
proteins
ec_number
3.4.11.-
uniprot
proteins
function
FUNCTION: Actin maturation protease that specifically mediates the cleavage of immature acetylated N-terminal actin, thereby contributing to actin maturation (PubMed:36173861). Cleaves N-terminal acetylated methionine of immature cytoplasmic beta- and gamma-actins ACTB and ACTG1 after translation (PubMed:36173861). Cleaves N-terminal acetylated cysteine of muscle alpha-actins ACTA1, ACTC1 and ACTA2 after canonical removal of N-terminal methionine (By similarity). {ECO:0000250|UniProtKB:J3QPC3, ECO:0000269|PubMed:36173861}.
uniprot
proteins
mass_dalton
37779
uniprot
proteins
mutagenesis
MUTAGEN 132; /note="C->A: Catalytically inactive, disrupts N-terminal cleavage of immature actin."; /evidence="ECO:0000269|PubMed:36173861
uniprot
proteins
protein_family
ACTMAP family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
36173861
uniprot
proteins
sequence_length
351
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:36173861}.
uniprot
proteins