G6pd2
entrez
14380
canonical
uniprot
P97324
canonical
ensembl
ENSMUSG00000089992
resolver
ensp
ENSMUSP00000131163
resolver
enst
ENSMUST00000053876
resolver
genesymbol
G6pd2
resolver
genesymbol_syn
G6pd-2
resolver
uniprot
G3UWD6
resolver
uniprot
Q0VB18
resolver
uniprot_entry
G3UWD6_MOUSE
resolver
uniprot_entry
G6PD2_MOUSE
resolver
uniprot_sec
Q0VB18
resolver
amino_acid_sequence
MAEQVTLSRTQVCGILREELYQNDAFHQADTHIFIIMGASGDLAKKKIYPTIWWLFRDGLLPKETFIVGYARSQLTVDDIQKQSEPFFKATPEERPKLEEFFTRNSYVVGQYDDPASYKHLNSYINALHQGMQANHLFYLALPPTVYEAVTKNIQETCMSQTGFNRIIVEKPFGRDLQSSNQLSNHISSLFREDQIYRIDHYLDKEMVQNLMVLRFANRIFGPIWNGDNIVCVILTFKEPFGTEGRGGYFDEFGIIRDVMQSHLLQMLCLVAMEKPATTDSDDVRNEKVKVLKCISEVETDNVILGQYVGNPNGEGEAANGYLDDPTVPRGSTTATFAAAVLYVKNERWDGVPFILRCGKALNERKAEVRLQFRDIPGDIFHQKCKRNELVIRMQPNEAVYTTMMTKKPGMFFNPEESELDLTYGNKYKNVKLPGAYERLILDVFCGCQMHFVRTDELREGWRIFTPLLHKIEREKPQPFPYVYGSRGPTEADELMRRVGFQYKGTYKGTHKH
uniprot
proteins
ec_number
1.-.-.-
uniprot
proteins
ec_number
1.1.1.49
uniprot
proteins
function
FUNCTION: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (PubMed:9169132). Also catalyzes the conversion of NAADPH, which is produced by enzymes such as DUOX1, DUOX2 and NOX5 from NAADP and promotes Ca(2+) signaling during T cell activation, back to NAADP (By similarity). {ECO:0000250|UniProtKB:P11413, ECO:0000269|PubMed:9169132}.
uniprot
proteins
mass_dalton
59126
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. {ECO:0000269|PubMed:9169132}.
uniprot
proteins
post_translational_modification
PTM: Acetylated by ELP3; acetylation inhibits its homodimerization and enzyme activity. Deacetylated by SIRT2; deacetylation stimulates its enzyme activity (By similarity). {ECO:0000250|UniProtKB:P11413}.
uniprot
proteins
protein_family
Glucose-6-phosphate dehydrogenase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9169132
uniprot
proteins
sequence_length
513
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P11413}. Membrane {ECO:0000250|UniProtKB:P11413}; Peripheral membrane protein {ECO:0000250|UniProtKB:P11413}.
uniprot
proteins