Spred2
entrez
114716
canonical
uniprot
Q924S7
canonical
ensembl
ENSMUSG00000045671
resolver
ensp
ENSMUSP00000090987
resolver
ensp
ENSMUSP00000159978
resolver
enst
ENSMUST00000093298
resolver
enst
ENSMUST00000249881
resolver
genesymbol
Spred2
resolver
uniprot
A0AAQ4VMS6
resolver
uniprot_entry
A0AAQ4VMS6_MOUSE
resolver
uniprot_entry
SPRE2_MOUSE
resolver
amino_acid_sequence
MTEETHPDDDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKVMHPEGNGRSGFLIHGERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRKAIEDLIEGSTTSSSTLHNEAELGDDDVFTTATDSSSNSSQKREPTTRTISSPTSCEHRKIYTLDPYPMDHYHPDQRLPRSYPQVTFPEDDEEIVRINPREKIWMTGYEDYRHAPVRGKYLDTTEDADSYVRFAKGEVPKHEYTYPYVDSSDFGFGEDPKGSVIKTQPPRAKSRRRKENGERSRCVYCRDMFNHEENRRGHCQDAPDAVRTCIRRVSCMWCADSMLYHCMSDPEGDYTDPCSCDTSDEKFCLRWMALIALSFLAPCMCCYLPLRACHRCGVMCRCCGGKHKAAA
uniprot
proteins
function
FUNCTION: Negatively regulates Ras signaling pathways and downstream activation of MAP kinases (PubMed:11493923). Recruits and translocates NF1 to the cell membrane, thereby enabling NF1-dependent hydrolysis of active GTP-bound Ras to inactive GDP-bound Ras (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (PubMed:29501879). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (PubMed:25576668). {ECO:0000250|UniProtKB:Q7Z698, ECO:0000269|PubMed:11493923, ECO:0000269|PubMed:25576668, ECO:0000269|PubMed:29501879}.
uniprot
proteins
mass_dalton
46794
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine and threonine residues. Phosphorylated on tyrosine. Phosphorylation of Tyr-224 and Tyr-227 are required for ubiquitination. {ECO:0000250|UniProtKB:Q7Z698}.; PTM: Ubiquitinated; leading to degradation by the proteasome. {ECO:0000250|UniProtKB:Q7Z698}.
uniprot
proteins
pubmed
11493923
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15580519
uniprot
proteins
pubmed
15946934
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17974561
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
25576668
uniprot
proteins
pubmed
28882895
uniprot
proteins
pubmed
29501879
uniprot
proteins
pubmed
34626534
uniprot
proteins
sequence_length
410
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11493923}; Peripheral membrane protein {ECO:0000269|PubMed:11493923}; Cytoplasmic side {ECO:0000269|PubMed:11493923}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q7Z698}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q7Z698}; Cytoplasmic side {ECO:0000250|UniProtKB:Q7Z698}. Cytoplasm {ECO:0000269|PubMed:11493923}. Note=Detected in the cytoplasm of the stratum spinosum cells, where it is associated with cytoplasmic vesicles that are supposed to be secretory granules. {ECO:0000250|UniProtKB:Q7Z698}.
uniprot
proteins