C3AR1
entrez
719
canonical
uniprot
Q16581
canonical
ensembl
ENSG00000171860
resolver
ensp
ENSP00000302079
resolver
ensp
ENSP00000574953
resolver
ensp
ENSP00000574954
resolver
ensp
ENSP00000632909
resolver
enst
ENST00000307637
resolver
enst
ENST00000904894
resolver
enst
ENST00000904895
resolver
enst
ENST00000962850
resolver
genesymbol
C3AR1
resolver
genesymbol_syn
AZ3B
resolver
genesymbol_syn
C3R1
resolver
genesymbol_syn
HNFAG09
resolver
hgnc
HGNC:1319
resolver
uniprot
A8K2H7
resolver
uniprot
O43771
resolver
uniprot
Q92868
resolver
uniprot_entry
A8K2H7_HUMAN
resolver
uniprot_entry
C3AR_HUMAN
resolver
uniprot_sec
O43771
resolver
uniprot_sec
Q92868
resolver
amino_acid_sequence
MASFSAETNSTDLLSQPWNEPPVILSMVILSLTFLLGLPGNGLVLWVAGLKMQRTVNTIWFLHLTLADLLCCLSLPFSLAHLALQGQWPYGRFLCKLIPSIIVLNMFASVFLLTAISLDRCLVVFKPIWCQNHRNVGMACSICGCIWVVAFVMCIPVFVYREIFTTDNHNRCGYKFGLSSSLDYPDFYGDPLENRSLENIVQPPGEMNDRLDPSSFQTNDHPWTVPTVFQPQTFQRPSADSLPRGSARLTSQNLYSNVFKPADVVSPKIPSGFPIEDHETSPLDNSDAFLSTHLKLFPSASSNSFYESELPQGFQDYYNLGQFTDDDQVPTPLVAITITRLVVGFLLPSVIMIACYSFIVFRMQRGRFAKSQSKTFRVAVVVVAVFLVCWTPYHIFGVLSLLTDPETPLGKTLMSWDHVCIALASANSCFNPFLYALLGKDFRKKARQSIQGILEAAFSEELTRSTHCPSNNVISERNSTTV
uniprot
proteins
function
FUNCTION: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a, stimulating chemotaxis, granule enzyme release and superoxide anion production (PubMed:12871936, PubMed:37852260, PubMed:8702752). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:37852260). C3AR1 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G alpha proteins and mediates inhibition of adenylate cyclase (PubMed:37852260). {ECO:0000269|PubMed:12871936, ECO:0000269|PubMed:37852260, ECO:0000269|PubMed:8702752}.
uniprot
proteins
mass_dalton
53864
uniprot
proteins
mutagenesis
MUTAGEN 449..481; /note="SIQGILEAAFSEELTRSTHCPSNNVISERNSTT->AIQGILEAAFAEELARAAHCPANNVIAERNAAA: Abolished ability to promote degranulation of leukocytes."; /evidence="ECO:0000269|PubMed:11564766
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of the C-terminus by GRK2 or GRK3 promotes association with beta-arrestin (ARRB1), leading to receptor desensitization and negative regulation of G protein-coupled receptor signaling. {ECO:0000269|PubMed:10508278, ECO:0000269|PubMed:11564766, ECO:0000269|PubMed:21799898, ECO:0000269|PubMed:23077507, ECO:0000269|PubMed:38175886}.; PTM: Among the sulfation sites Tyr-174 is essential for binding of C3a anaphylatoxin. {ECO:0000269|PubMed:12871936}.; PTM: O-glycosylated. {ECO:0000269|PubMed:23234360}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10508278
uniprot
proteins
pubmed
11564766
uniprot
proteins
pubmed
12871936
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21799898
uniprot
proteins
pubmed
23077507
uniprot
proteins
pubmed
23234360
uniprot
proteins
pubmed
37169960
uniprot
proteins
pubmed
37852260
uniprot
proteins
pubmed
38175886
uniprot
proteins
pubmed
8605247
uniprot
proteins
pubmed
8702752
uniprot
proteins
pubmed
8765043
uniprot
proteins
sequence_length
482
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11564766}; Multi-pass membrane protein {ECO:0000269|PubMed:37169960, ECO:0000269|PubMed:37852260}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..46; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:37852260, ECO:0007744|PDB:8HK2, ECO:0007744|PDB:8HK3, ECO:0007744|PDB:8I95, ECO:0007744|PDB:8I97, ECO:0007744|PDB:8I9L, ECO:0007744|PDB:8I9S, ECO:0007744|PDB:8J6D"; TRANSMEM 60..84; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:37852260, ECO:0007744|PDB:8HK2, ECO:0007744|PDB:8HK3, ECO:0007744|PDB:8I95, ECO:0007744|PDB:8I97, ECO:0007744|PDB:8I9L, ECO:0007744|PDB:8I9S, ECO:0007744|PDB:8J6D"; TRANSMEM 92..118; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:37852260, ECO:0007744|PDB:8HK2, ECO:0007744|PDB:8HK3, ECO:0007744|PDB:8I95, ECO:0007744|PDB:8I97, ECO:0007744|PDB:8I9L, ECO:0007744|PDB:8I9S, ECO:0007744|PDB:8J6D"; TRANSMEM 141..160; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:37852260, ECO:0007744|PDB:8HK2, ECO:0007744|PDB:8HK3, ECO:0007744|PDB:8I95, ECO:0007744|PDB:8I97, ECO:0007744|PDB:8I9L, ECO:0007744|PDB:8I9S, ECO:0007744|PDB:8J6D"; TRANSMEM 333..354; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:37852260, ECO:0007744|PDB:8HK2, ECO:0007744|PDB:8HK3, ECO:0007744|PDB:8I95, ECO:0007744|PDB:8I97, ECO:0007744|PDB:8I9L, ECO:0007744|PDB:8I9S, ECO:0007744|PDB:8J6D"; TRANSMEM 378..403; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:37852260, ECO:0007744|PDB:8HK2, ECO:0007744|PDB:8HK3, ECO:0007744|PDB:8I95, ECO:0007744|PDB:8I97, ECO:0007744|PDB:8I9L, ECO:0007744|PDB:8I9S, ECO:0007744|PDB:8J6D"; TRANSMEM 412..435; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:37852260, ECO:0007744|PDB:8HK2, ECO:0007744|PDB:8HK3, ECO:0007744|PDB:8I95, ECO:0007744|PDB:8I97, ECO:0007744|PDB:8I9L, ECO:0007744|PDB:8I9S, ECO:0007744|PDB:8J6D
uniprot
proteins