PYY
entrez
5697
canonical
uniprot
P10082
canonical
ensembl
ENSG00000131096
resolver
ensp
ENSP00000353198
resolver
ensp
ENSP00000467310
resolver
ensp
ENSP00000509262
resolver
genesymbol
PYY
resolver
hgnc
HGNC:9748
resolver
uniprot
Q5U5Q6
resolver
uniprot
Q6FGH8
resolver
uniprot_entry
PYY_HUMAN
resolver
uniprot_sec
Q5U5Q6
resolver
uniprot_sec
Q6FGH8
resolver
amino_acid_sequence
MVFVRRPWPALTTVLLALLVCLGALVDAYPIKPEAPREDASPEELNRYYASLRHYLNLVTRQRYGKRDGPDTLLSKTFFPDGEDRPVRSRSEGPDLW
uniprot
proteins
function
FUNCTION: [Peptide YY]: Ligand for neuropeptide Y receptor type 1 (NPY1R) and neuropeptide Y receptor type 2 (NPY2R) (PubMed:1317848, PubMed:7592910, PubMed:36525977). Also binds NPY5R (By similarity). Receptor binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production (PubMed:1317848, PubMed:7592910). Receptor activation by PYY also leads to an increase of intracellular Ca(2+) levels (PubMed:1317848, PubMed:36525977, PubMed:7592910). This gut peptide inhibits exocrine pancreatic secretion (By similarity). Involved in the regulation of colonic antisecretory tone, and colonic contractility (By similarity). {ECO:0000250|UniProtKB:P68005, ECO:0000250|UniProtKB:Q9EPS2, ECO:0000269|PubMed:1317848, ECO:0000269|PubMed:36525977, ECO:0000269|PubMed:7592910}.; FUNCTION: [Peptide YY(3-36)]: Is a NPY2R agonist involved in the down-regulation of appetite and food intake, probably acting on receptors located on proopiomelanocortin(POMC)-releasing and neuropeptide Y(NPY)-releasing neurons in the arcuate nucleus of hypothalamus (PubMed:12167864). In NPY-releasing neurons, NPY2R activation by PYY(3-36) leads to membrane hyperpolarization and reduced release of the orexigenic neuropeptide NPY (By similarity). {ECO:0000250|UniProtKB:Q9EPS2, ECO:0000269|PubMed:12167864}.
uniprot
proteins
mass_dalton
11145
uniprot
proteins
post_translational_modification
PTM: The peptide YY form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro) to generate peptide YY(3-36). {ECO:0000269|PubMed:21314817}.
uniprot
proteins
protein_family
NPY family
uniprot
proteins
pubmed
12167864
uniprot
proteins
pubmed
1317848
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16819834
uniprot
proteins
pubmed
21314817
uniprot
proteins
pubmed
2587421
uniprot
proteins
pubmed
3202875
uniprot
proteins
pubmed
35180645
uniprot
proteins
pubmed
36525977
uniprot
proteins
pubmed
3840109
uniprot
proteins
pubmed
7592910
uniprot
proteins
pubmed
8318545
uniprot
proteins
sequence_length
97
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Peptide YY]: Secreted {ECO:0000269|PubMed:3840109}.
uniprot
proteins