Mcts1
entrez
302500
canonical
uniprot
Q4G009
canonical
ensembl
ENSRNOG00000002563
resolver
ensembl
ENSRNOG00055025089
resolver
ensembl
ENSRNOG00060017835
resolver
ensembl
ENSRNOG00065010446
resolver
ensp
ENSRNOP00000061717
resolver
ensp
ENSRNOP00000074032
resolver
ensp
ENSRNOP00055035272
resolver
ensp
ENSRNOP00060024709
resolver
ensp
ENSRNOP00065012953
resolver
enst
ENSRNOT00000066677
resolver
enst
ENSRNOT00000080894
resolver
enst
ENSRNOT00055043240
resolver
enst
ENSRNOT00060030557
resolver
enst
ENSRNOT00065016916
resolver
genesymbol
Mcts1
resolver
uniprot
A0A0G2K724
resolver
uniprot_entry
A0A0G2K724_RAT
resolver
uniprot_entry
MCTS1_RAT
resolver
amino_acid_sequence
MGKGRFDEKENVSNCIQLKTSVIKGIKNQLLEQFPGIEPWLNQIMPKKDPVKIVRCHEHIEILTVNGELLFFRQREGPFYPTLRLLHKYPFILPHQQVDKGAIKFVLSGANIMCPGLTSPGAKLYPAAVDTIVAIMAEGKQHALCVGVMKMSAEDIEKVNKGIGIENIHYLNDGLWHMKTYK
uniprot
proteins
function
FUNCTION: Translation regulator forming a complex with DENR to promote translation reinitiation. Translation reinitiation is the process where the small ribosomal subunit remains attached to the mRNA following termination of translation of a regulatory upstream ORF (uORF), and resume scanning on the same mRNA molecule to initiate translation of a downstream ORF, usually the main ORF (mORF). The MCTS1/DENR complex is pivotal to two linked mechanisms essential for translation reinitiation. Firstly, the dissociation of deacylated tRNAs from post-termination 40S ribosomal complexes during ribosome recycling. Secondly, the recruitment in an EIF2-independent manner of aminoacylated initiator tRNA to P site of 40S ribosomes for a new round of translation. This regulatory mechanism governs the translation of more than 150 genes which translation reinitiation is MCTS1/DENR complex-dependent. Consequently, modulates various unrelated biological processes including cell cycle regulation and DNA damage signaling and repair. Notably, it positively regulates interferon gamma immunity to mycobacteria by enhancing the translation of JAK2. {ECO:0000250|UniProtKB:Q9ULC4}.
uniprot
proteins
mass_dalton
20550
uniprot
proteins
post_translational_modification
PTM: Phosphorylation is critical for stabilization and promotion of cell proliferation. {ECO:0000250}.
uniprot
proteins
protein_family
MCTS1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
182
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9ULC4}. Note=Nuclear relocalization after DNA damage. {ECO:0000250|UniProtKB:Q9ULC4}.
uniprot
proteins