Tmem120a
entrez
288591
canonical
uniprot
Q5HZE2
canonical
ensembl
ENSRNOG00000001441
resolver
ensembl
ENSRNOG00055000337
resolver
ensembl
ENSRNOG00060010832
resolver
ensembl
ENSRNOG00065001802
resolver
ensp
ENSRNOP00000001960
resolver
ensp
ENSRNOP00055000455
resolver
ensp
ENSRNOP00060014294
resolver
ensp
ENSRNOP00065001685
resolver
enst
ENSRNOT00055000591
resolver
enst
ENSRNOT00060018336
resolver
enst
ENSRNOT00065002407
resolver
genesymbol
Tmem120a
resolver
uniprot_entry
TACAN_RAT
resolver
amino_acid_sequence
MQSPPPDPLGDCLRNWEDLQQDFQGIQETHRLYRVKLEELTKLQDNCTNSITRQKKRLQELALVLKKCRPSLPSESLEAAQELESQIKERQGLFFDMEAYLPKKNGLYLSLVLGNVNVTLLSKQAKFAYKDEYEKFKLYLTIILIVISFTCRFLLNSRVTDAAFNFLLVWYYCTLTIRESILINNGSRIKGWWVFHHYVSTFLSGVMLTWPDGLMYQKFRNQFLSFSMYQSFVQFLQYYYQSGCLYRLRALGERHTMDLTVEGFQSWMWRGLTFLLPFLFFGHFWQLFNALTLFNLARDPECKEWQVLMCGLPFLLLFLGNFFTTLRVVHQKFHSQQHGSKKD
uniprot
proteins
function
FUNCTION: Multifunctional protein involved in mechanosensation, and plays an essential role in lipid metabolism and adipocyte differentiation. May function as a potential ion channel involved in sensing mechanical stimuli. Mediates the mechanosensitivity of the PKD2-TMEM120A channel complex through direct physical interaction (By similarity). TMEM120A seems to affect mechanosensation by inhibiting PIEZO2 channels, possibly by altering cellular lipid content (By similarity). TMEM120A is structurally similar to a lipid-modifying enzyme, ELOVL7, and contains a bound coenzyme A molecule, which suggests it might function as an enzyme in lipid metabolism. Additionally, implicated in innate immune response against Zika virus. Acts as a key activator of the antiviral signaling involving STING1 (By similarity). {ECO:0000250|UniProtKB:Q8C1E7, ECO:0000250|UniProtKB:Q9BXJ8}.
uniprot
proteins
mass_dalton
40657
uniprot
proteins
protein_family
TMEM120 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
343
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9BXJ8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9BXJ8}. Nucleus inner membrane {ECO:0000250|UniProtKB:Q8C1E7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9BXJ8}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9BXJ8}.
uniprot
proteins
transmembrane_region
TRANSMEM 133..152; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q9BXJ8"; TRANSMEM 159..177; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q9BXJ8"; TRANSMEM 191..209; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q9BXJ8"; TRANSMEM 219..240; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q9BXJ8"; TRANSMEM 271..294; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q9BXJ8"; TRANSMEM 305..330; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q9BXJ8
uniprot
proteins