ADO
entrez
84890
canonical
uniprot
Q96SZ5
canonical
ensembl
ENSG00000181915
resolver
ensp
ENSP00000362888
resolver
enst
ENST00000373783
resolver
genesymbol
ADO
resolver
genesymbol_syn
C10orf22
resolver
hgnc
HGNC:23506
resolver
uniprot
B1AL29
resolver
uniprot
B3KXN9
resolver
uniprot_entry
AEDO_HUMAN
resolver
uniprot_entry
B3KXN9_HUMAN
resolver
uniprot_sec
B1AL29
resolver
amino_acid_sequence
MPRDNMASLIQRIARQACLTFRGSGGGRGASDRDAASGPEAPMQPGFPENLSKLKSLLTQLRAEDLNIAPRKATLQPLPPNLPPVTYMHIYETDGFSLGVFLLKSGTSIPLHDHPGMHGMLKVLYGTVRISCMDKLDAGGGQRPRALPPEQQFEPPLQPREREAVRPGVLRSRAEYTEASGPCILTPHRDNLHQIDAVEGPAAFLDILAPPYDPDDGRDCHYYRVLEPVRPKEASSSACDLPREVWLLETPQADDFWCEGEPYPGPKVFP
uniprot
proteins
ec_number
1.13.11.19
uniprot
proteins
function
FUNCTION: Plays a vital role in regulating thiol metabolism and preserving oxygen homeostasis by oxidizing the sulfur of cysteamine and N-terminal cysteine-containing proteins to their corresponding sulfinic acids using O2 as a cosubstrate (PubMed:17581819, PubMed:29752763, PubMed:31273118, PubMed:32601061). Catalyzes the oxidation of cysteamine (2-aminoethanethiol) to hypotaurine (PubMed:17581819, PubMed:29752763, PubMed:32601061). Catalyzes the oxidation of regulators of G protein signaling 4 (RGS4) and 5 (RGS5) and interleukin-32 (IL32) (PubMed:31273118, PubMed:32601061). {ECO:0000269|PubMed:17581819, ECO:0000269|PubMed:29752763, ECO:0000269|PubMed:31273118, ECO:0000269|PubMed:32601061}.
uniprot
proteins
mass_dalton
29751
uniprot
proteins
mutagenesis
MUTAGEN 87; /note="Y->A: Moderate reduction in enzyme activity."; /evidence="ECO:0000269|PubMed:29752763"; MUTAGEN 222; /note="Y->A,F: Significant reduction in enzyme activity."; /evidence="ECO:0000269|PubMed:29752763"; MUTAGEN 223; /note="Y->A: No significant reduction in enzyme activity."; /evidence="ECO:0000269|PubMed:29752763
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17581819
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
29752763
uniprot
proteins
pubmed
31273118
uniprot
proteins
pubmed
32601061
uniprot
proteins
pubmed
34508780
uniprot
proteins
sequence_length
270
uniprot
proteins