Nfatc2ip
entrez
18020
canonical
uniprot
O09130
canonical
ensembl
ENSMUSG00000030722
resolver
ensp
ENSMUSP00000075094
resolver
ensp
ENSMUSP00000325722
resolver
ensp
ENSMUSP00000325723
resolver
enst
ENSMUST00000075671
resolver
genesymbol
Nfatc2ip
resolver
genesymbol_syn
Nip45
resolver
uniprot
Q8CDG2
resolver
uniprot
Q9CVY5
resolver
uniprot_entry
NF2IP_MOUSE
resolver
uniprot_sec
Q8CDG2
resolver
uniprot_sec
Q9CVY5
resolver
amino_acid_sequence
MAEPLRGRGPRSRGGRGARRARGARGRCPRARQSPARLIPDTVLVDLVSDSDEEVLEVADPVEVPVARLPAPAKPEQDSDSDSEGAAEGPAGAPRTLVRRRRRRLLDPGEAPVVPVYSGKVQSSLNLIPDNSSLLKLCPSEPEDEADLTNSGSSPSEDDALPSGSPWRKKLRKKCEKEEKKMEEFPDQDISPLPQPSSRNKSRKHTEALQKLREVNKRLQDLRSCLSPKQHQSPALQSTDDEVVLVEGPVLPQSSRLFTLKIRCRADLVRLPVRMSEPLQNVVDHMANHLGVSPNRILLLFGESELSPTATPSTLKLGVADIIDCVVLASSSEATETSQELRLRVQGKEKHQMLEISLSPDSPLKVLMSHYEEAMGLSGHKLSFFFDGTKLSGKELPADLGLESGDLIEVWG
uniprot
proteins
function
FUNCTION: In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression. Down-regulates formation of poly-SUMO chains by UBE2I/UBC9. {ECO:0000269|PubMed:20077568, ECO:0000269|PubMed:20133688}.
uniprot
proteins
mass_dalton
45121
uniprot
proteins
post_translational_modification
PTM: Methylation at the N-terminus by PRMT1 modulates interaction with the NFAT complex and results in augmented cytokine production. {ECO:0000269|PubMed:15327772}.
uniprot
proteins
pubmed
11435475
uniprot
proteins
pubmed
15327772
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16352630
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
20077568
uniprot
proteins
pubmed
20133688
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8943202
uniprot
proteins
sequence_length
412
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=TRAF1 is associated with a fraction of NFATC2IP in the cytoplasm and prevents its translocation to the nucleus.
uniprot
proteins