ADAT2
entrez
134637
canonical
uniprot
Q7Z6V5
canonical
ensembl
ENSG00000189007
resolver
ensp
ENSP00000237283
resolver
ensp
ENSP00000475651
resolver
ensp
ENSP00000791258
resolver
genesymbol
ADAT2
resolver
genesymbol_syn
DEADC1
resolver
hgnc
HGNC:21172
resolver
uniprot
A6NL12
resolver
uniprot
B3KWY3
resolver
uniprot
Q7Z327
resolver
uniprot
Q8IY39
resolver
uniprot_entry
ADAT2_HUMAN
resolver
uniprot_sec
A6NL12
resolver
uniprot_sec
B3KWY3
resolver
uniprot_sec
Q7Z327
resolver
uniprot_sec
Q8IY39
resolver
amino_acid_sequence
MEAKAAPKPAASGACSVSAEETEKWMEEAMHMAKEALENTEVPVGCLMVYNNEVVGKGRNEVNQTKNATRHAEMVAIDQVLDWCRQSGKSPSEVFEHTVLYVTVEPCIMCAAALRLMKIPLVVYGCQNERFGGCGSVLNIASADLPNTGRPFQCIPGYRAEEAVEMLKTFYKQENPNAPKSKVRKKECQKS
uniprot
proteins
ec_number
3.5.4.33
uniprot
proteins
function
FUNCTION: Catalytic subunit of the tRNA-specific adenosine-34 deaminase complex, composed of the ADAT2 catalytic subunit and the ADAT3 regulatory subunit, which deaminates adenosine-34 (the first, also called wobble position of the anticodon) to inosine in many tRNAs. Inosine-34 allows the decoding of 3 different nucleotides at the third position of mRNA codons, as inosine is able to pair with U, C, and A. Binding of the ADAT2-ADAT3 complex to tRNA is mediated by the N-terminus of ADAT3 which rotates with respect to the catalytic domain of the complex, formed by ADAT2 and the ADAT3 C-terminal domain, to position the tRNA anticodon stem-loop correctly in the ADAT2 active site. The ADAT2-ADAT3 complex is required for radial migration of projection neurons in the developing brain cortex, and the catalytic activity of the complex is necessary for this function. {ECO:0000250|UniProtKB:Q6P6J0}.
uniprot
proteins
mass_dalton
21046
uniprot
proteins
protein_family
ADAT2 subfamily
uniprot
proteins
protein_family
Cytidine and deoxycytidylate deaminase family
uniprot
proteins
pubmed
12457566
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
25916855
uniprot
proteins
sequence_length
191
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25916855}. Cytoplasm {ECO:0000250|UniProtKB:Q6P6J0}. Note=The ADAT2-ADAT3 complex shows a diffused expression pattern in both the cytoplasm and the nucleus. {ECO:0000250|UniProtKB:Q6P6J0}.
uniprot
proteins