NRF
entrez
55922
canonical
uniprot
O15226
canonical
ensembl
ENSG00000186416
resolver
ensembl
ENSG00000292244
resolver
ensp
ENSP00000518188
resolver
enst
ENST00000710306
resolver
genesymbol
NKRF
resolver
genesymbol
NRF
resolver
genesymbol_syn
ITBA4
resolver
genesymbol_syn
NKRF
resolver
genesymbol_syn
NRF
resolver
hgnc
HGNC:19374
resolver
uniprot
A0AAG2UWQ9
resolver
uniprot
A3F769
resolver
uniprot
G3V1N1
resolver
uniprot
Q4VC41
resolver
uniprot
Q9UJ91
resolver
uniprot_entry
A0AAG2UWQ9_HUMAN
resolver
uniprot_entry
A3F769_HUMAN
resolver
uniprot_entry
NKRF_HUMAN
resolver
uniprot_sec
G3V1N1
resolver
uniprot_sec
Q4VC41
resolver
uniprot_sec
Q9UJ91
resolver
amino_acid_sequence
MEKILQMAEGIDIGEMPSYDLVLSKPSKGQKRHLSTCDGQNPPKKQAGSKFHARPRFEPVHFVASSSKDERQEDPYGPQTKEVNEQTHFASMPRDIYQDYTQDSFSIQDGNSQYCDSSGFILTKDQPVTANMYFDSGNPAPSTTSQQANSQSTPEPSPSQTFPESVVAEKQYFIEKLTATIWKNLSNPEMTSGSDKINYTYMLTRCIQACKTNPEYIYAPLKEIPPADIPKNKKLLTDGYACEVRCQNIYLTTGYAGSKNGSRDRATELAVKLLQKRIEVRVVRRKFKHTFGEDLVVCQIGMSSYEFPPALKPPEDLVVLGKDASGQPIFNASAKHWTNFVITENANDAIGILNNSASFNKMSIEYKYEMMPNRTWRCRVFLQDHCLAEGYGTKKTSKHAAADEALKILQKTQPTYPSVKSSQCHTGSSPRGSGKKKDIKDLVVYENSSNPVCTLNDTAQFNRMTVEYVYERMTGLRWKCKVILESEVIAEAVGVKKTVKYEAAGEAVKTLKKTQPTVINNLKKGAVEDVISRNEIQGRSAEEAYKQQIKEDNIGNQLLRKMGWTGGGLGKSGEGIREPISVKEQHKREGLGLDVERVNKIAKRDIEQIIRNYARSESHTDLTFSRELTNDERKQIHQIAQKYGLKSKSHGVGHDRYLVVGRKRRKEDLLDQLKQEGQVGHYELVMPQAN
uniprot
proteins
function
FUNCTION: Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15 (PubMed:12381793). Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity (PubMed:12381793). Also involved in the regulation of IL-8 transcription (PubMed:12381793). May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes (PubMed:10562553). {ECO:0000269|PubMed:10562553, ECO:0000269|PubMed:12381793}.
uniprot
proteins
mass_dalton
77673
uniprot
proteins
mutagenesis
MUTAGEN 555; /note="G->E: Abolished interaction with DHX15."; /evidence="ECO:0000269|PubMed:32179686"; MUTAGEN 559; /note="L->E: Abolished interaction with DHX15."; /evidence="ECO:0000269|PubMed:32179686"; MUTAGEN 564; /note="W->A: Abolished interaction with DHX15."; /evidence="ECO:0000269|PubMed:32179686"; MUTAGEN 569; /note="L->E: Abolished interaction with DHX15."; /evidence="ECO:0000269|PubMed:32179686"; MUTAGEN 590; /note="G->E: Decreased, but not abolished interaction, with DHX15."; /evidence="ECO:0000269|PubMed:32179686"; MUTAGEN 591; /note="L->E: Decreased, but not abolished interaction, with DHX15."; /evidence="ECO:0000269|PubMed:32179686
uniprot
proteins
pubmed
10562553
uniprot
proteins
pubmed
12381793
uniprot
proteins
pubmed
12429849
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24462208
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
32179686
uniprot
proteins
pubmed
9224902
uniprot
proteins
sequence_length
690
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849}.
uniprot
proteins