Tmprss11c
entrez
435845
canonical
uniprot
Q1JRP2
canonical
ensembl
ENSMUSG00000061184
resolver
ensp
ENSMUSP00000062915
resolver
enst
ENSMUST00000059424
resolver
genesymbol
Tmprss11c
resolver
uniprot_entry
TM11C_MOUSE
resolver
amino_acid_sequence
MARGQPRRSEEQWTALQNRTECKTKIKLTRCGKITLGILTAVLAAVLIGLIAYFAACGKDSFYYHVSFKVNNIDYDSKFAKPYSQEYMDLNKRIVSLMNETFHESKLRKQYVKAHTVQVSKAKGKVVIHAVLKFKACYRNNVEKYWESVETTLYQKLKGQTGLLIDSSSFKFSDIAMPIAEDLLNTCCGRRTIIHRGHKVAGGQDAEEGEWPWQASLQQNSVHRCGATLISNYWLITAAHCFIRAANPKDWKVSFGFLLSKPQAPRAVKNIIIHENYSYPAHDNDIAVVRLSSPVLYESNIRRACLPEATQKFPPNSDVVVTGWGTLKSDGDSPNILQKGKVKIIDNKTCNSGKAYGGMITPGMMCAGFLKGRVDACQGDSGGPLVSEDSKGIWFLAGIVSWGDECALPNKPGVYTRVTYYRDWITSKTGL
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Serine protease which has a preference for Arg or Lys in position P1 and uncharged residues in positions P2 and P3. Shows specificity towards FGF2 in vitro. {ECO:0000269|PubMed:18215125}.
uniprot
proteins
mass_dalton
48073
uniprot
proteins
mutagenesis
MUTAGEN 190..191; /note="RR->AA: Strongly reduced autocatalytic cleavage; when associated with A-196 and A-199. Slightly reduced autocatalytic cleavage; when associated with A-196."; /evidence="ECO:0000269|PubMed:18215125"; MUTAGEN 196; /note="R->A: Strongly reduced autocatalytic cleavage; when associated with A-199. Strongly reduced autocatalytic cleavage; when associated with A-199 and 190-A-A-191. Slightly reduced autocatalytic cleavage; when associated with 190-A-A-191."; /evidence="ECO:0000269|PubMed:18215125"; MUTAGEN 199; /note="K->A: Reduced autocatalytic cleavage. Strongly reduced autocatalytic cleavage; when associated with A-196. Strongly reduced autocatalytic cleavage; when associated with A-196 and 190-A-A-191."; /evidence="ECO:0000269|PubMed:18215125"; MUTAGEN 381; /note="S->A: Abolishes autocatalytic cleavage."; /evidence="ECO:0000269|PubMed:18215125
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved via an autocatalytic mechanism. {ECO:0000269|PubMed:18215125}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18215125
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
431
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18215125}; Single-pass type II membrane protein {ECO:0000305}. Cell projection, dendrite {ECO:0000269|PubMed:18215125}. Perikaryon {ECO:0000269|PubMed:18215125}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..54; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins