Slc52a2
entrez
52710
canonical
uniprot
Q9D8F3
canonical
ensembl
ENSMUSG00000022560
resolver
ensp
ENSMUSP00000023220
resolver
ensp
ENSMUSP00000249633
resolver
genesymbol
Slc52a2
resolver
genesymbol_syn
Gpr172b
resolver
genesymbol_syn
Rft1
resolver
uniprot
Q8CCV8
resolver
uniprot_entry
S52A2_MOUSE
resolver
uniprot_sec
Q8CCV8
resolver
activity_regulation
ACTIVITY REGULATION: Riboflavin transport is Na(+)-independent but moderately pH-sensitive (By similarity). Activity is strongly inhibited by riboflavin analogs, such as lumiflavin (By similarity). Weakly inhibited by flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN) (By similarity). {ECO:0000250|UniProtKB:Q9HAB3}.
uniprot
proteins
amino_acid_sequence
MAAPPLGRLVLTHLLVALFGMGSWAAVNGIWVELPVVVKELPEGWSLPSYLSVLVALGNLGLLLVTLWRRLARGKGEQVPIRVVQGLGIVGTGLLASLWNHVAPVAGKPYSVAFLTLAFVLALACCASNVTFLPFLSHLPPPFLRSFFLGQGLSALLPCVLALGQGVGRLECLHVPANRTTGPPIEVSPINFPERFSATTFFWVLTALLGTSAAAFQGLLLLLPSPTSEPTTGTGLRVETPGTEEEEEEEEASPLQEPPGQVAGIVSSPDPKAHQLFSSRSACLLGLLAITNALTNGVLPAVQSFSCLPYGRLAYHLAVVLGSCANPLACFLAMAVLCRSLAGLCGLSLLGMLLGSYLMTLAALSPCPPLVGTSAGVVLVVLSWVLCAGTFSYIKVAISSMLHSGGRPALLAAGVAIQVGSLLGAVAMFPPTSIYRVFRSGKDCVDQCGL
uniprot
proteins
function
FUNCTION: Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. May also act as a receptor for 4-hydroxybutyrate. {ECO:0000250|UniProtKB:Q9HAB3}.
uniprot
proteins
mass_dalton
46864
uniprot
proteins
protein_family
Riboflavin transporter family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
450
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9HAB3}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 14..34; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 47..67; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 86..106; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 112..132; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 147..167; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 201..221; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 282..302; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 317..337; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 344..364; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 369..389; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 409..429; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins