O88910
uniprot
O88910
canonical
amino_acid_sequence
MPVLSEDSGLHETLALLTSQLRPDSNHREEMGFLRDVFSEKSLSYLMKIHEKLRYYERQSPTPVLHSAMALAEDVMEELQAASVHSDERELLQLLSTPHLRAVLMVHDTVAQKNFDPVLPPLPDNIDEDFEEESVKIVRLVKNKEPLGATIRRDEHSGAVVVARIMRGGAADRSGLVHVGDELREVNGIAVLHKRPDEISQILAQSQGSITLKIIPATQEEDRFKDSKVFMRALFHYDPREDRAIPCQEAGLPFQRRQVLEVVSQDDPTWWQAKRVGDTNLRAGLIPSKQFQERRLSYRRTTGTLPSPQNFKKPPYDQPCDKETCDCDGYFKGHYVAGLRRSFRLGCRERLGGSQEAKVPTGAESQVLLTYEEVARYQHQPGERPRLVVLIGSLGAHLHELKQRVVAEDPQQFAVAVPHTTRPRKSHERDGVEYHFVSKQAFEADVHHNKFLEHGEYKENLYGTSLEAIQAVMAKNKVCLVDVEPEALRHLRTPEFKPYVIFVKPAIQERRKTPPVSPDSEDIASSLDEQQQEMAASAAFIDQHYGHLIDTVLVRQDLQEPAASSELS
uniprot
proteins
function
FUNCTION: Participates in cell spreading through the phosphoinositide-3-kinase (PI3K) pathway by connecting CADM1 to DLG1 and the regulatory subunit of phosphoinositide-3-kinase (PI3K) (By similarity). Stabilizes HTR2C at the plasma membrane and prevents its desensitization (PubMed:16914526). May participates in the maintenance of adherens junctions (PubMed:23658188, PubMed:23893895). {ECO:0000250|UniProtKB:Q13368, ECO:0000269|PubMed:16914526, ECO:0000269|PubMed:23658188, ECO:0000269|PubMed:23893895}.
uniprot
proteins
mass_dalton
64401
uniprot
proteins
protein_family
MAGUK family
uniprot
proteins
pubmed
14988405
uniprot
proteins
pubmed
15466885
uniprot
proteins
pubmed
16519681
uniprot
proteins
pubmed
16914526
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23658188
uniprot
proteins
pubmed
23893895
uniprot
proteins
pubmed
9838122
uniprot
proteins
sequence_length
568
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:23658188, ECO:0000269|PubMed:23893895}. Cell membrane {ECO:0000250|UniProtKB:Q13368}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q13368}. Note=Localized in apical villi of Mueller glia cells (PubMed:23893895). Localized at the apical membrane in the developing cortex and colocalized with apical proteins and adherens junction proteins (PubMed:23658188). Localized at the outer limiting membrane (OLM), and outer plexiform (OPL) of retina (By similarity). {ECO:0000250|UniProtKB:Q13368, ECO:0000269|PubMed:23658188, ECO:0000269|PubMed:23893895}.
uniprot
proteins