CPLX4
entrez
339302
canonical
uniprot
Q7Z7G2
canonical
ensembl
ENSG00000166569
resolver
ensp
ENSP00000299721
resolver
enst
ENST00000299721
resolver
genesymbol
CPLX4
resolver
hgnc
HGNC:24330
resolver
uniprot
F1T0L6
resolver
uniprot_entry
CPLX4_HUMAN
resolver
uniprot_sec
F1T0L6
resolver
amino_acid_sequence
MAFLMKSMISNQVKNLGFGGGSEENKEEGGASDPAAAQGMTREEYEEYQKQMIEEKMERDAAFTQKKAERACLRVHLREKYRLPKSEMDENQIQMAGDDVDLPEDLRKMVDEDQEEEEDKDSILGQIQNLQNMDLDTIKEKAQATFTEIKQTAEQKCSVM
uniprot
proteins
function
FUNCTION: Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity). Required for the maintenance of synaptic ultrastructure in the adult retina (By similarity). Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (By similarity). Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release (By similarity). {ECO:0000250|UniProtKB:Q80WM3}.
uniprot
proteins
mass_dalton
18336
uniprot
proteins
post_translational_modification
PTM: Farnesylation mediates presynaptic targeting and is important for function in neurotransmitter release. {ECO:0000250|UniProtKB:Q80WM3}.
uniprot
proteins
protein_family
Complexin/synaphin family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15911881
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21697133
uniprot
proteins
sequence_length
160
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Synapse {ECO:0000250|UniProtKB:Q80WM3}. Cell membrane; Lipid-anchor {ECO:0000250|UniProtKB:Q80WM3}. Note=Enriched at the synaptic terminal. {ECO:0000250|UniProtKB:Q80WM3}.
uniprot
proteins