Q8VHG5
uniprot
Q8VHG5
canonical
amino_acid_sequence
MSKDSSLHPKYQMASNIPRETSFLVPKEPTRYLPFQMCQSPLVTPTRPLQSSHSVHERDLHQKDSQEPSRNSGSMPLSDKYYNKQSGPVATRKCRKERTVYSKEQKCLLQEHFHQCQNPDLEQRKALALLIGVTEYKIQTWFKNRRAKECRKSSQLPRRIGSGPHYRPTSSSGGEVPDFAASPDSVCQRHVNVSYPPEFRPSRNSPHQEFNSSLIDQPLEDMCFSKSHIISEHPRQKCRELSREPGHLSSDRSGCSNVLSSPSPAAGAESSCDIPSGLSLSPQLGPPSMTQNSESTFSMCQTPSVLSPLPELSPLSNSLDQMAIFSKIDQVCEIYQKNTRSKKQRKETEKNTVQNLMHGQDSCEITESPKGTVSLPSSAY
uniprot
proteins
function
FUNCTION: Transcription factor required for zygotic genome activation (ZGA), a critical event in early embryonic development during which the developmental control passes from maternally provided mRNAs to the expression of the zygotic genome after fertilization (PubMed:37459895). Cannot compensate for loss of other members of the Obox family, suggesting that its function differs from other Obox family members (PubMed:37459895). May regulate expression of histone genes in embryonic stem cells (PubMed:20004198). Also involved in completion of meiosis of oocytes during the meiosis-I/meiosis-II transition (PubMed:20154267, PubMed:22384421). Required to maintain the nuclear membrane of the germinal vesicle in oocytes (PubMed:26762402). {ECO:0000269|PubMed:20004198, ECO:0000269|PubMed:20154267, ECO:0000269|PubMed:22384421, ECO:0000269|PubMed:26762402, ECO:0000269|PubMed:37459895}.
uniprot
proteins
mass_dalton
42638
uniprot
proteins
protein_family
Obox subfamily
uniprot
proteins
protein_family
Paired homeobox family
uniprot
proteins
pubmed
11991721
uniprot
proteins
pubmed
20004198
uniprot
proteins
pubmed
20154267
uniprot
proteins
pubmed
22384421
uniprot
proteins
pubmed
23614109
uniprot
proteins
pubmed
26762402
uniprot
proteins
pubmed
37459895
uniprot
proteins
sequence_length
380
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:23614109}. Note=Nuclear localization is dependent on its homeobox domain. {ECO:0000269|PubMed:23614109}.
uniprot
proteins