Inpp5f
entrez
101490
canonical
uniprot
Q8CDA1
canonical
ensembl
ENSMUSG00000042105
resolver
ensp
ENSMUSP00000045910
resolver
ensp
ENSMUSP00000113700
resolver
ensp
ENSMUSP00000146197
resolver
ensp
ENSMUSP00000268261
resolver
genesymbol
Inpp5f
resolver
genesymbol_syn
Kiaa0966
resolver
genesymbol_syn
Sac2
resolver
uniprot
B2RQ14
resolver
uniprot
Q3UCS0
resolver
uniprot
Q6NX83
resolver
uniprot
Q6ZQ16
resolver
uniprot
Q8C8G7
resolver
uniprot
Q8CBW2
resolver
uniprot_entry
B2RQ14_MOUSE
resolver
uniprot_entry
SAC2_MOUSE
resolver
uniprot_sec
Q3UCS0
resolver
uniprot_sec
Q6NX83
resolver
uniprot_sec
Q6ZQ16
resolver
uniprot_sec
Q8C8G7
resolver
uniprot_sec
Q8CBW2
resolver
amino_acid_sequence
MELFQAKDHYILQQGERALWCSRRDGGLQLRPATDLLLAWNPICLGLVEGVIGKIQLHSDLPWWLILIRQKALVGKLPGDHEVCKVTKIAVLSLSEMEPQELELELCKKHHFGINKPEKIIPSPDDSKFLLKTFTNIKSNVSAPNKKKVKESKEKEKLERRLLEELLKMFMDSESFYYSLTYDLTNSVQRQSTGERDGRPLWQKVDDRFFWNKYMIQALTEIGTPDVDFWIIPIIQGFVQIEELVVNYNESSDDDKSSPETPPQDSTCVDDIHPRFLVALISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIHVHHHTLSFIQTRGSVPVFWSQVGYRYNPRPRLDKSEKETVDCFCAHFEEQLKIYKKQVIVNLVDQAGREKIIGDAYLKQVLLFNNPKLTYVSFDFHEHCRGMKFENVQTLTDAIHDIIIDMKWCWVDQAGVICKQEGIFRVNCMDCLDRTNVVQAAIARVVMEQQLKKLGVMPPEQPLPVKCNRTYQIMWANNGDSISRQYAGTAALKGDFTRTGERKLAGVMKDGVNSANRYYLSRFKDAYRQAVIDLMQGVPVTEDLYSIFTKEKEHEALHKESQRSHQELISQLLQSYMQLLLPGDEKFHGGWALVDCDPSLTDAAHRDVEVLLLLSNAAYYVAYYDDEVDKVNQYQRLGLEDLERIEIGPEPTLFGKPKFSCMRLHYRCKEAGGYFHTLRAVPRSPEEDGKDTLQCIAEMLQITKQAMGLDVPIIEKKLERKSSKPHEDIIGIRSQNQGSLAQGKSFLMSKFSSLNQKVKQTKSNVNIGNLRKLGNFTKPEMKVNFLKPNLKVNLWKSDSSLETMENPGVMGNKVQGESDGDISSDNDSYHSDEFLTNSKSEEDKQLANSLESVGPIDYILPSCGIIVSAPRLGSRSQSASSIDVSTHAPSEAAAGPGSELGKGLESPLKKSPSADSIHTRTGFTKPMDVYCQRFVQDAQNKMNDLSEIRSVAQKSEEGSHKTNRVSNEETQSEPMGQTPPRPSQLNVSCSVAGPPFLSVEPVHSVLSQKTPSSGSSLLELEAGLCVTPSSESSSSRAVSPFAKIRSSMVQVANITQAGLTHGINLAVAKVQKSPAEPEAVNEIQQNELKNMFTQCQTRIIQI
uniprot
proteins
ec_number
3.1.3.-
uniprot
proteins
function
FUNCTION: Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PtdIns(4)P). May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to PtdIns, for a sequential dephosphorylation of (PtdIns(4,5)P2) at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869668, PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (By similarity). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (By similarity). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (PubMed:19875726). May play a role as negative regulator of axon regeneration after central nervous system injuries (PubMed:26203138). May be involved in insulin granule docking at the plasma membrane of pancreatic cells, an essential step for insulin secretion (PubMed:31533953). {ECO:0000250|UniProtKB:Q9Y2H2, ECO:0000269|PubMed:17322895, ECO:0000269|PubMed:25869668, ECO:0000269|PubMed:25869669, ECO:0000269|PubMed:26203138, ECO:0000269|PubMed:31533953}.
uniprot
proteins
mass_dalton
127608
uniprot
proteins
mutagenesis
MUTAGEN 460; /note="D->A: Has a diffuse cytosolic localization."; /evidence="ECO:0000269|PubMed:25869668"; MUTAGEN 460; /note="D->N: Loss of inositol 4-phosphatase activity. No effect on subcellular localization. No effect on interaction with OCRL, INPP5B and IPP4A."; /evidence="ECO:0000269|PubMed:25869668
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17322895
uniprot
proteins
pubmed
19875726
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25869668
uniprot
proteins
pubmed
25869669
uniprot
proteins
pubmed
26203138
uniprot
proteins
pubmed
31533953
uniprot
proteins
sequence_length
1132
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane, clathrin-coated pit {ECO:0000269|PubMed:25869668}. Early endosome {ECO:0000269|PubMed:25869668}. Recycling endosome {ECO:0000250|UniProtKB:Q9Y2H2}. Note=Also found on macropinosomes. {ECO:0000269|PubMed:25869668}.
uniprot
proteins