PHLDA3
entrez
23612
canonical
uniprot
Q9Y5J5
canonical
ensembl
ENSG00000174307
resolver
ensp
ENSP00000356278
resolver
ensp
ENSP00000356280
resolver
enst
ENST00000367309
resolver
enst
ENST00000367311
resolver
genesymbol
PHLDA3
resolver
genesymbol_syn
TIH1
resolver
hgnc
HGNC:8934
resolver
uniprot
B2R5A4
resolver
uniprot
Q53HD6
resolver
uniprot
Q8NBW9
resolver
uniprot_entry
PHLA3_HUMAN
resolver
uniprot_sec
B2R5A4
resolver
uniprot_sec
Q53HD6
resolver
uniprot_sec
Q8NBW9
resolver
amino_acid_sequence
MTAAATATVLKEGVLEKRSGGLLQLWKRKRCVLTERGLQLFEAKGTGGRPKELSFARIKAVECVESTGRHIYFTLVTEGGGEIDFRCPLEDPGWNAQITLGLVKFKNQQAIQTVRARQSLGTGTLVS
uniprot
proteins
function
FUNCTION: p53/TP53-regulated repressor of Akt/AKT1 signaling. Represses AKT1 by preventing AKT1-binding to membrane lipids, thereby inhibiting AKT1 translocation to the cellular membrane and activation. Contributes to p53/TP53-dependent apoptosis by repressing AKT1 activity. Its direct transcription regulation by p53/TP53 may explain how p53/TP53 can negatively regulate AKT1. May act as a tumor suppressor. {ECO:0000269|PubMed:19203586}.
uniprot
proteins
mass_dalton
13891
uniprot
proteins
protein_family
PHLDA3 family
uniprot
proteins
pubmed
10594239
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15940259
uniprot
proteins
pubmed
19203586
uniprot
proteins
pubmed
21269460
uniprot
proteins
sequence_length
127
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19203586}. Membrane {ECO:0000269|PubMed:19203586}; Peripheral membrane protein {ECO:0000269|PubMed:19203586}.
uniprot
proteins