SNX32
entrez
254122
canonical
uniprot
Q86XE0
canonical
ensembl
ENSG00000172803
resolver
ensp
ENSP00000310620
resolver
genesymbol
SNX32
resolver
genesymbol_syn
SNX6B
resolver
hgnc
HGNC:26423
resolver
uniprot
Q8IW53
resolver
uniprot
Q96NG4
resolver
uniprot_entry
SNX32_HUMAN
resolver
uniprot_sec
Q8IW53
resolver
uniprot_sec
Q96NG4
resolver
amino_acid_sequence
METYAEVGKEGKPSCASVDLQGDSSLQVEISDAVSERDKVKFTVQTKSCLPHFAQTEFSVVRQHEEFIWLHDAYVENEEYAGLIIPPAPPRPDFEASREKLQKLGEGDSSVTREEFAKMKQELEAEYLAIFKKTVAMHEVFLQRLAAHPTLRRDHNFFVFLEYGQDLSVRGKNRKELLGGFLRNIVKSADEALITGMSGLKEVDDFFEHERTFLLEYHTRIRDACLRADRVMRAHKCLADDYIPISAALSSLGTQEVNQLRTSFLKLAELFERLRKLEGRVASDEDLKLSDMLRYYMRDSQAAKDLLYRRLRALADYENANKALDKARTRNREVRPAESHQQLCCQRFERLSDSAKQELMDFKSRRVSSFRKNLIELAELELKHAKASTLILRNTLVALKGEP
uniprot
proteins
function
FUNCTION: Involved in endosomal trafficking of cargo proteins, including transferrin-bound transferrin receptor (TFRC), cation-independent mannose-6-phosphate receptor (IGF2R) and epidermal growth factor receptor (EGFR) (PubMed:37158588, PubMed:39073202). Functions redundantly with other BAR domain-containing sorting nexins in endosome to trans-Golgi network transport of IGF2R (PubMed:39073202). Regulates in coordination with SNX5 sorting and trafficking of EGF-activated EGFR to multivesicular bodies for lysosomal degradation (PubMed:39073202). Plays an essential role in neurite outgrowth, controlling basigin/EMMPRIN (BSG) trafficking to the cell surface (By similarity). {ECO:0000250|UniProtKB:Q80ZJ7, ECO:0000269|PubMed:37158588, ECO:0000269|PubMed:39073202}.
uniprot
proteins
mass_dalton
46399
uniprot
proteins
mutagenesis
MUTAGEN 131; /note="F->D: Loss of interaction with TFRC, IGF2R and BSG. Does not affect interaction with SNX1."; /evidence="ECO:0000269|PubMed:37158588"; MUTAGEN 256; /note="E->R: Decreased interaction with SNX5."; /evidence="ECO:0000269|PubMed:39073202
uniprot
proteins
protein_family
Sorting nexin family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
37158588
uniprot
proteins
pubmed
39073202
uniprot
proteins
sequence_length
403
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:37158588}. Early endosome {ECO:0000269|PubMed:37158588, ECO:0000269|PubMed:39073202}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:37158588, ECO:0000269|PubMed:39073202}. Recycling endosome {ECO:0000269|PubMed:37158588, ECO:0000269|PubMed:39073202}. Late endosome {ECO:0000269|PubMed:39073202}.
uniprot
proteins