HLA-DPB1
entrez
3115
canonical
uniprot
P04440
canonical
ensembl
ENSG00000215048
resolver
ensembl
ENSG00000223865
resolver
ensembl
ENSG00000226826
resolver
ensembl
ENSG00000230763
resolver
ensembl
ENSG00000236693
resolver
ensembl
ENSG00000237710
resolver
ensp
ENSP00000382422
resolver
ensp
ENSP00000389288
resolver
ensp
ENSP00000396095
resolver
ensp
ENSP00000407674
resolver
ensp
ENSP00000408146
resolver
ensp
ENSP00000412654
resolver
ensp
ENSP00000414196
resolver
ensp
ENSP00000577534
resolver
ensp
ENSP00000577536
resolver
ensp
ENSP00000636861
resolver
ensp
ENSP00000636862
resolver
enst
ENST00000399500
resolver
enst
ENST00000411749
resolver
enst
ENST00000418931
resolver
enst
ENST00000425130
resolver
enst
ENST00000428835
resolver
enst
ENST00000433800
resolver
enst
ENST00000454006
resolver
enst
ENST00000907475
resolver
enst
ENST00000907477
resolver
enst
ENST00000966802
resolver
enst
ENST00000966803
resolver
genesymbol
HLA-DPB1
resolver
genesymbol_syn
HLA-DP1B
resolver
hgnc
HGNC:4940
resolver
uniprot
A0PFJ7
resolver
uniprot
A5I886
resolver
uniprot
A8YPB3
resolver
uniprot
B5U8B4
resolver
uniprot
B7VF80
resolver
uniprot
B7VF87
resolver
uniprot
B8ZX68
resolver
uniprot
B8ZYT0
resolver
uniprot
B9W5S8
resolver
uniprot
B9W6F7
resolver
uniprot
B9W6F9
resolver
uniprot
C0MPP5
resolver
uniprot
C0MPQ2
resolver
uniprot
C0MPQ3
resolver
uniprot
C0MPQ5
resolver
uniprot
C0MPQ6
resolver
uniprot
C0MPQ7
resolver
uniprot
C4R9J5
resolver
uniprot
C5IZL1
resolver
uniprot
H0Y7G7
resolver
uniprot
I4EC15
resolver
uniprot
O00259
resolver
uniprot
O19698
resolver
uniprot
O19700
resolver
uniprot
O19702
resolver
uniprot
O19749
resolver
uniprot
O46884
resolver
uniprot
O77952
resolver
uniprot
O98215
resolver
uniprot
O98216
resolver
uniprot
O98217
resolver
uniprot
O98218
resolver
uniprot
O98219
resolver
uniprot
O98222
resolver
uniprot
O98223
resolver
uniprot
P01916
resolver
uniprot
P04232
resolver
uniprot
P13763
resolver
uniprot
P79493
resolver
uniprot
P79608
resolver
uniprot
Q0P0L4
resolver
uniprot
Q0ZFN3
resolver
uniprot
Q14279
resolver
uniprot
Q27S71
resolver
uniprot
Q29682
resolver
uniprot
Q29684
resolver
uniprot
Q29698
resolver
uniprot
Q29714
resolver
uniprot
Q29775
resolver
uniprot
Q29776
resolver
uniprot
Q29778
resolver
uniprot
Q29779
resolver
uniprot
Q29781
resolver
uniprot
Q29827
resolver
uniprot
Q29828
resolver
uniprot
Q29879
resolver
uniprot
Q29880
resolver
uniprot
Q29898
resolver
uniprot
Q29977
resolver
uniprot
Q2MGW3
resolver
uniprot
Q30015
resolver
uniprot
Q30031
resolver
uniprot
Q30032
resolver
uniprot
Q30033
resolver
uniprot
Q30034
resolver
uniprot
Q30050
resolver
uniprot
Q30051
resolver
uniprot
Q30052
resolver
uniprot
Q30053
resolver
uniprot
Q30054
resolver
uniprot
Q30055
resolver
uniprot
Q30174
resolver
uniprot
Q4GY31
resolver
uniprot
Q4JHD8
resolver
uniprot
Q5ENE0
resolver
uniprot
Q5ENE1
resolver
uniprot
Q5ENW3
resolver
uniprot
Q5EP46
resolver
uniprot
Q5EP47
resolver
uniprot
Q5EP49
resolver
uniprot
Q5EP51
resolver
uniprot
Q5EP52
resolver
uniprot
Q5EP53
resolver
uniprot
Q5EP56
resolver
uniprot
Q5I4H8
resolver
uniprot
Q5I4H9
resolver
uniprot
Q5ISH4
resolver
uniprot
Q5ISH5
resolver
uniprot
Q5SQ73
resolver
uniprot
Q5STP2
resolver
uniprot
Q5YLA6
resolver
uniprot
Q6IVX1
resolver
uniprot
Q6LBX2
resolver
uniprot
Q6LBX3
resolver
uniprot
Q6LBX4
resolver
uniprot
Q6LBX5
resolver
uniprot
Q6LBX6
resolver
uniprot
Q6LBX7
resolver
uniprot
Q6PWX6
resolver
uniprot
Q6TAS4
resolver
uniprot
Q714U1
resolver
uniprot
Q714U2
resolver
uniprot
Q7YQ10
resolver
uniprot
Q860Z7
resolver
uniprot
Q8HWL7
resolver
uniprot
Q8HWT5
resolver
uniprot
Q8SNC4
resolver
uniprot
Q95HC1
resolver
uniprot
Q95IT7
resolver
uniprot
Q95IT8
resolver
uniprot
Q9BD13
resolver
uniprot
Q9GIM2
resolver
uniprot
Q9GIM4
resolver
uniprot
Q9GIX6
resolver
uniprot
Q9GJ41
resolver
uniprot
Q9MY67
resolver
uniprot
Q9TNT7
resolver
uniprot
Q9TQE2
resolver
uniprot
Q9XS11
resolver
uniprot
Q9XS12
resolver
uniprot_entry
DPB1_HUMAN
resolver
uniprot_entry
H0Y7G7_HUMAN
resolver
uniprot_entry
I4EC15_HUMAN
resolver
uniprot_sec
A0PFJ7
resolver
uniprot_sec
A5I886
resolver
uniprot_sec
A8YPB3
resolver
uniprot_sec
B5U8B4
resolver
uniprot_sec
B7VF80
resolver
uniprot_sec
B7VF87
resolver
uniprot_sec
B8ZX68
resolver
uniprot_sec
B8ZYT0
resolver
uniprot_sec
B9W5S8
resolver
uniprot_sec
B9W6F7
resolver
uniprot_sec
B9W6F9
resolver
uniprot_sec
C0MPP5
resolver
uniprot_sec
C0MPQ2
resolver
uniprot_sec
C0MPQ3
resolver
uniprot_sec
C0MPQ5
resolver
uniprot_sec
C0MPQ6
resolver
uniprot_sec
C0MPQ7
resolver
uniprot_sec
C4R9J5
resolver
uniprot_sec
C5IZL1
resolver
uniprot_sec
O00259
resolver
uniprot_sec
O19698
resolver
uniprot_sec
O19700
resolver
uniprot_sec
O19702
resolver
uniprot_sec
O19749
resolver
uniprot_sec
O46884
resolver
uniprot_sec
O77952
resolver
uniprot_sec
O98215
resolver
uniprot_sec
O98216
resolver
uniprot_sec
O98217
resolver
uniprot_sec
O98218
resolver
uniprot_sec
O98219
resolver
uniprot_sec
O98222
resolver
uniprot_sec
O98223
resolver
uniprot_sec
P01916
resolver
uniprot_sec
P04232
resolver
uniprot_sec
P13763
resolver
uniprot_sec
P79493
resolver
uniprot_sec
P79608
resolver
uniprot_sec
Q0P0L4
resolver
uniprot_sec
Q0ZFN3
resolver
uniprot_sec
Q14279
resolver
uniprot_sec
Q27S71
resolver
uniprot_sec
Q29682
resolver
uniprot_sec
Q29684
resolver
uniprot_sec
Q29698
resolver
uniprot_sec
Q29714
resolver
uniprot_sec
Q29775
resolver
uniprot_sec
Q29776
resolver
uniprot_sec
Q29778
resolver
uniprot_sec
Q29779
resolver
uniprot_sec
Q29781
resolver
uniprot_sec
Q29827
resolver
uniprot_sec
Q29828
resolver
uniprot_sec
Q29879
resolver
uniprot_sec
Q29880
resolver
uniprot_sec
Q29898
resolver
uniprot_sec
Q29977
resolver
uniprot_sec
Q2MGW3
resolver
uniprot_sec
Q30015
resolver
uniprot_sec
Q30031
resolver
uniprot_sec
Q30032
resolver
uniprot_sec
Q30033
resolver
uniprot_sec
Q30034
resolver
uniprot_sec
Q30050
resolver
uniprot_sec
Q30051
resolver
uniprot_sec
Q30052
resolver
uniprot_sec
Q30053
resolver
uniprot_sec
Q30054
resolver
uniprot_sec
Q30055
resolver
uniprot_sec
Q30174
resolver
uniprot_sec
Q4GY31
resolver
uniprot_sec
Q4JHD8
resolver
uniprot_sec
Q5ENE0
resolver
uniprot_sec
Q5ENE1
resolver
uniprot_sec
Q5ENW3
resolver
uniprot_sec
Q5EP46
resolver
uniprot_sec
Q5EP47
resolver
uniprot_sec
Q5EP49
resolver
uniprot_sec
Q5EP51
resolver
uniprot_sec
Q5EP52
resolver
uniprot_sec
Q5EP53
resolver
uniprot_sec
Q5EP56
resolver
uniprot_sec
Q5I4H8
resolver
uniprot_sec
Q5I4H9
resolver
uniprot_sec
Q5ISH4
resolver
uniprot_sec
Q5ISH5
resolver
uniprot_sec
Q5SQ73
resolver
uniprot_sec
Q5STP2
resolver
uniprot_sec
Q5YLA6
resolver
uniprot_sec
Q6IVX1
resolver
uniprot_sec
Q6LBX2
resolver
uniprot_sec
Q6LBX3
resolver
uniprot_sec
Q6LBX4
resolver
uniprot_sec
Q6LBX5
resolver
uniprot_sec
Q6LBX6
resolver
uniprot_sec
Q6LBX7
resolver
uniprot_sec
Q6PWX6
resolver
uniprot_sec
Q6TAS4
resolver
uniprot_sec
Q714U1
resolver
uniprot_sec
Q714U2
resolver
uniprot_sec
Q7YQ10
resolver
uniprot_sec
Q860Z7
resolver
uniprot_sec
Q8HWL7
resolver
uniprot_sec
Q8HWT5
resolver
uniprot_sec
Q8SNC4
resolver
uniprot_sec
Q95HC1
resolver
uniprot_sec
Q95IT7
resolver
uniprot_sec
Q95IT8
resolver
uniprot_sec
Q9BD13
resolver
uniprot_sec
Q9GIM2
resolver
uniprot_sec
Q9GIM4
resolver
uniprot_sec
Q9GIX6
resolver
uniprot_sec
Q9GJ41
resolver
uniprot_sec
Q9MY67
resolver
uniprot_sec
Q9TNT7
resolver
uniprot_sec
Q9TQE2
resolver
uniprot_sec
Q9XS11
resolver
uniprot_sec
Q9XS12
resolver
amino_acid_sequence
MMVLQVSAAPRTVALTALLMVLLTSVVQGRATPENYLFQGRQECYAFNGTQRFLERYIYNREEFARFDSDVGEFRAVTELGRPAAEYWNSQKDILEEKRAVPDRMCRHNYELGGPMTLQRRVQPRVNVSPSKKGPLQHHNLLVCHVTDFYPGSIQVRWFLNGQEETAGVVSTNLIRNGDWTFQILVMLEMTPQQGDVYTCQVEHTSLDSPVTVEWKAQSDSARSKTLTGAGGFVLGLIICGVGIFMHRRSKKVQRGSA
uniprot
proteins
function
FUNCTION: Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC class II loading compartments. In addition to APCs, other cells of the gastrointestinal tract, such as epithelial cells, express MHC class II molecules and CD74 and act as APCs, which is an unusual trait of the GI tract. To produce a MHC class II molecule that presents an antigen, three MHC class II molecules (heterodimers of an alpha and a beta chain) associate with a CD74 trimer in the ER to form a heterononamer. Soon after the entry of this complex into the endosomal/lysosomal system where antigen processing occurs, CD74 undergoes a sequential degradation by various proteases, including CTSS and CTSL, leaving a small fragment termed CLIP (class-II-associated invariant chain peptide). The removal of CLIP is facilitated by HLA-DM via direct binding to the alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class II molecules until primary high affinity antigenic peptides are bound. The MHC II molecule bound to a peptide is then transported to the cell membrane surface. In B-cells, the interaction between HLA-DM and MHC class II molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to express HLA-DO. Lysosomal microenvironment has been implicated in the regulation of antigen loading into MHC II molecules, increased acidification produces increased proteolysis and efficient peptide loading.
uniprot
proteins
mass_dalton
29159
uniprot
proteins
protein_family
MHC class II family
uniprot
proteins
pubmed
10090623
uniprot
proteins
pubmed
10958363
uniprot
proteins
pubmed
11169249
uniprot
proteins
pubmed
11556983
uniprot
proteins
pubmed
11684289
uniprot
proteins
pubmed
11782281
uniprot
proteins
pubmed
12135440
uniprot
proteins
pubmed
12694578
uniprot
proteins
pubmed
12890000
uniprot
proteins
pubmed
12890001
uniprot
proteins
pubmed
1358867
uniprot
proteins
pubmed
1412421
uniprot
proteins
pubmed
1440570
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
1481203
uniprot
proteins
pubmed
15140044
uniprot
proteins
pubmed
1529429
uniprot
proteins
pubmed
15361132
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15982263
uniprot
proteins
pubmed
16147881
uniprot
proteins
pubmed
16189666
uniprot
proteins
pubmed
16866899
uniprot
proteins
pubmed
17241953
uniprot
proteins
pubmed
18046453
uniprot
proteins
pubmed
19092054
uniprot
proteins
pubmed
19533806
uniprot
proteins
pubmed
19775376
uniprot
proteins
pubmed
2242906
uniprot
proteins
pubmed
2460556
uniprot
proteins
pubmed
2714855
uniprot
proteins
pubmed
2838415
uniprot
proteins
pubmed
2987832
uniprot
proteins
pubmed
2998758
uniprot
proteins
pubmed
3036829
uniprot
proteins
pubmed
6098459
uniprot
proteins
pubmed
6310612
uniprot
proteins
pubmed
6330724
uniprot
proteins
pubmed
7638863
uniprot
proteins
pubmed
7744621
uniprot
proteins
pubmed
7806296
uniprot
proteins
pubmed
7817379
uniprot
proteins
pubmed
7839356
uniprot
proteins
pubmed
7901923
uniprot
proteins
pubmed
7912859
uniprot
proteins
pubmed
8085260
uniprot
proteins
pubmed
8344726
uniprot
proteins
pubmed
8525482
uniprot
proteins
pubmed
8598037
uniprot
proteins
pubmed
8773318
uniprot
proteins
pubmed
8781129
uniprot
proteins
pubmed
8824162
uniprot
proteins
pubmed
8851734
uniprot
proteins
pubmed
8896187
uniprot
proteins
pubmed
9174146
uniprot
proteins
pubmed
9694359
uniprot
proteins
pubmed
9756410
uniprot
proteins
pubmed
9756411
uniprot
proteins
sequence_length
258
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein. Endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Note=The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
uniprot
proteins
transmembrane_region
TRANSMEM 226..246; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins