GSKIP
entrez
51527
canonical
uniprot
Q9P0R6
canonical
ensembl
ENSG00000100744
resolver
ensp
ENSP00000412315
resolver
ensp
ENSP00000450420
resolver
ensp
ENSP00000451188
resolver
ensp
ENSP00000451384
resolver
ensp
ENSP00000522507
resolver
ensp
ENSP00000522508
resolver
ensp
ENSP00000522509
resolver
ensp
ENSP00000522510
resolver
ensp
ENSP00000522511
resolver
ensp
ENSP00000522512
resolver
ensp
ENSP00000585283
resolver
ensp
ENSP00000585284
resolver
ensp
ENSP00000585285
resolver
ensp
ENSP00000585286
resolver
ensp
ENSP00000585287
resolver
ensp
ENSP00000637874
resolver
ensp
ENSP00000637876
resolver
enst
ENST00000438650
resolver
enst
ENST00000554182
resolver
enst
ENST00000555181
resolver
enst
ENST00000556095
resolver
enst
ENST00000852448
resolver
enst
ENST00000852449
resolver
enst
ENST00000852450
resolver
enst
ENST00000852451
resolver
enst
ENST00000852452
resolver
enst
ENST00000852453
resolver
enst
ENST00000915224
resolver
enst
ENST00000915225
resolver
enst
ENST00000915226
resolver
enst
ENST00000915227
resolver
enst
ENST00000915228
resolver
enst
ENST00000967814
resolver
enst
ENST00000967817
resolver
genesymbol
GSKIP
resolver
genesymbol_syn
C14orf129
resolver
hgnc
HGNC:20343
resolver
uniprot
B3KSZ0
resolver
uniprot
Q9BST1
resolver
uniprot
Q9NWK0
resolver
uniprot_entry
GSKIP_HUMAN
resolver
uniprot_sec
B3KSZ0
resolver
uniprot_sec
Q9BST1
resolver
uniprot_sec
Q9NWK0
resolver
amino_acid_sequence
METDCNPMELSSMSGFEEGSELNGFEGTDMKDMRLEAEAVVNDVLFAVNNMFVSKSLRCADDVAYINVETKERNRYCLELTEAGLKVVGYAFDQVDDHLQTPYHETVYSLLDTLSPAYREAFGNALLQRLEALKRDGQS
uniprot
proteins
function
FUNCTION: A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets (PubMed:16981698, PubMed:25920809, PubMed:27484798). The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively (PubMed:16981698, PubMed:27484798). Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B (PubMed:25920809). During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (PubMed:19830702). {ECO:0000269|PubMed:16981698, ECO:0000269|PubMed:19830702, ECO:0000269|PubMed:25920809, ECO:0000269|PubMed:27484798}.
uniprot
proteins
mass_dalton
15648
uniprot
proteins
mutagenesis
MUTAGEN 41..45; /note="VNDVL->PNDVP: Abolishes interaction with PRKAR2A and PRKAR2B. Abolishes acquired resistance against oxidative stress-induced apoptosis under activated cAMP signaling. Decreases PKA-mediated DNM1L phosphorylation."; /evidence="ECO:0000269|PubMed:25920809"; MUTAGEN 42; /note="N->I: Abolishes interaction with PRKAR2A. Prevents the Wnt-induced transcription. Does not alter the phosphorylation of CTNNB1 in the presence of Wnt."; /evidence="ECO:0000269|PubMed:27484798"; MUTAGEN 109; /note="S->A: No effect on GSK3B-mediated phosphorylation. Reduces to 30 % GSK3B-mediated phosphorylation; when associated with A-113. Reduces to 30 % GSK3B-mediated phosphorylation; when associated with A-113 and A-115."; /evidence="ECO:0000269|PubMed:16981698"; MUTAGEN 113; /note="T->A: No effect on GSK3B-mediated phosphorylation. Reduces to 30 % GSK3B-mediated phosphorylation; when associated with A-109. Reduces to 30 % GSK3B-mediated phosphorylation; when associated with A-113 and A-115."; /evidence="ECO:0000269|PubMed:16981698"; MUTAGEN 115; /note="S->A: No effect on GSK3B-mediated phosphorylation. Reduces to 30 % GSK3B-mediated phosphorylation; when associated with A-109. Reduces to 30 % GSK3B-mediated phosphorylation; when associated with A109 and A-113."; /evidence="ECO:0000269|PubMed:16981698"; MUTAGEN 130; /note="L->P: Loss of interaction with GSK3B. Abolishes GSK3B-mediated phosphorylation. Prevents beta-catenin accumulation in the cytoplasm and nucleus. Prevents the Wnt-induced transcription. Decreases PKA-mediated phosphorylation of GSK3B. Abolishes acquired resistance against oxidative stress-induced apoptosis under activated cAMP signaling. Decreases PKA-mediated DNM1L phosphorylation."; /evidence="ECO:0000269|PubMed:16981698, ECO:0000269|PubMed:25920809, ECO:0000269|PubMed:27484798
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by GSK3B. {ECO:0000269|PubMed:16981698}.
uniprot
proteins
protein_family
GSKIP family
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16981698
uniprot
proteins
pubmed
19830702
uniprot
proteins
pubmed
20007971
uniprot
proteins
pubmed
25920809
uniprot
proteins
pubmed
27484798
uniprot
proteins
sequence_length
139
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16981698, ECO:0000269|PubMed:20007971}. Nucleus {ECO:0000269|PubMed:20007971}.
uniprot
proteins