IRAK4
entrez
51135
canonical
uniprot
Q9NWZ3
canonical
ensembl
ENSG00000198001
resolver
ensp
ENSP00000408734
resolver
ensp
ENSP00000446490
resolver
ensp
ENSP00000479889
resolver
ensp
ENSP00000521219
resolver
ensp
ENSP00000521220
resolver
ensp
ENSP00000521221
resolver
ensp
ENSP00000607251
resolver
genesymbol
IRAK4
resolver
hgnc
HGNC:17967
resolver
uniprot
B2RAP9
resolver
uniprot
B4E359
resolver
uniprot
Q69FE1
resolver
uniprot
Q69FE3
resolver
uniprot
Q8TDF7
resolver
uniprot
Q9Y589
resolver
uniprot_entry
B2RAP9_HUMAN
resolver
uniprot_entry
B4E359_HUMAN
resolver
uniprot_entry
IRAK4_HUMAN
resolver
uniprot_entry
Q69FE3_HUMAN
resolver
uniprot_sec
Q69FE1
resolver
uniprot_sec
Q8TDF7
resolver
uniprot_sec
Q9Y589
resolver
amino_acid_sequence
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency 67 (IMD67) [MIM:607676]: An autosomal recessive primary immunodeficiency characterized by recurrent, life-threatening systemic and invasive bacterial infections beginning in infancy or early childhood. {ECO:0000269|PubMed:12637671, ECO:0000269|PubMed:12925671, ECO:0000269|PubMed:16950813, ECO:0000269|PubMed:17878374, ECO:0000269|PubMed:19663824, ECO:0000269|PubMed:21057262, ECO:0000269|PubMed:24316379}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374). Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections. {ECO:0000269|PubMed:11960013, ECO:0000269|PubMed:12538665, ECO:0000269|PubMed:15084582, ECO:0000269|PubMed:17217339, ECO:0000269|PubMed:17337443, ECO:0000269|PubMed:17878374, ECO:0000269|PubMed:17997719, ECO:0000269|PubMed:20400509, ECO:0000269|PubMed:24316379}.
uniprot
proteins
mass_dalton
51530
uniprot
proteins
mutagenesis
MUTAGEN 213; /note="K->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:15084582
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250}.
uniprot
proteins
protein_family
Pelle subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
TKL Ser/Thr protein kinase family
uniprot
proteins
pubmed
10508479
uniprot
proteins
pubmed
11960013
uniprot
proteins
pubmed
12496252
uniprot
proteins
pubmed
12538665
uniprot
proteins
pubmed
12637671
uniprot
proteins
pubmed
12925671
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15084582
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16286016
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
16950813
uniprot
proteins
pubmed
16951688
uniprot
proteins
pubmed
17161373
uniprot
proteins
pubmed
17217339
uniprot
proteins
pubmed
17312103
uniprot
proteins
pubmed
17337443
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17878374
uniprot
proteins
pubmed
17997719
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19663824
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20400509
uniprot
proteins
pubmed
20485341
uniprot
proteins
pubmed
21057262
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21269878
uniprot
proteins
pubmed
21325272
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24316379
uniprot
proteins
pubmed
33238146
uniprot
proteins
sequence_length
460
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21325272}.
uniprot
proteins