Rab8a
entrez
17274
canonical
uniprot
P55258
canonical
ensembl
ENSMUSG00000003037
resolver
ensp
ENSMUSP00000003121
resolver
enst
ENSMUST00000003121
resolver
genesymbol
Rab8a
resolver
genesymbol_syn
Mel
resolver
genesymbol_syn
Rab8
resolver
genesymbol_syn
Rab8A
resolver
uniprot
Q0PD50
resolver
uniprot
Q8VCF6
resolver
uniprot_entry
Q0PD50_MOUSE
resolver
uniprot_entry
RAB8A_MOUSE
resolver
uniprot_sec
Q8VCF6
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) such as RAB3IP/Rabin8 and RPGR which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors (GDIs) which inhibit the dissociation of the nucleotide from the GTPase (By similarity). Activated in response to insulin (By similarity). {ECO:0000250|UniProtKB:P35280, ECO:0000250|UniProtKB:P61006}.
uniprot
proteins
amino_acid_sequence
MAKTYDYLFKLLLIGDSGVGKTCVLFRFSEDAFNSTFISTIGIDFKIRTIELDGKRIKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNEKSFDNIRNWIRNIEEHASADVEKMILGNKCDVNDKRQVSKERGEKLALDYGIKFMETSAKANINVENAFFTLARDIKAKMDKKLEGNSPQGSSHGVKITVEQQKRTSFFRCSLL
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB8A is involved in polarized vesicular trafficking and neurotransmitter release. Together with RAB11A, RAB3IP, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity). Regulates the compacted morphology of the Golgi (By similarity). Together with MYO5B and RAB11A participates in epithelial cell polarization (By similarity). Also involved in membrane trafficking to the cilium and ciliogenesis (PubMed:25860027). Together with MICALL2, may also regulate adherens junction assembly (PubMed:18094055). May play a role in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore play a role in glucose homeostasis (By similarity). Involved in autophagy (By similarity). Participates in the export of a subset of neosynthesized proteins through a Rab8-Rab10-Rab11-dependent endososomal export route (By similarity). Targeted to and stabilized on stressed lysosomes through LRRK2 phosphorylation (PubMed:30209220). Suppresses stress-induced lysosomal enlargement through EHBP1 and EHNP1L1 effector proteins (By similarity). {ECO:0000250|UniProtKB:P35280, ECO:0000250|UniProtKB:P61006, ECO:0000269|PubMed:18094055, ECO:0000269|PubMed:30209220, ECO:0000305|PubMed:25860027}.
uniprot
proteins
mass_dalton
23668
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Thr-72 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2 (By similarity). Phosphorylation by LRRK2 is required for localization to stressed lysosomes (PubMed:30209220). {ECO:0000250|UniProtKB:P61006, ECO:0000269|PubMed:30209220}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
12578829
uniprot
proteins
pubmed
12590134
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16541104
uniprot
proteins
pubmed
17509819
uniprot
proteins
pubmed
18094055
uniprot
proteins
pubmed
1886711
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19625297
uniprot
proteins
pubmed
20643351
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23807208
uniprot
proteins
pubmed
25860027
uniprot
proteins
pubmed
26824392
uniprot
proteins
pubmed
29125462
uniprot
proteins
pubmed
30209220
uniprot
proteins
pubmed
33976349
uniprot
proteins
pubmed
8643544
uniprot
proteins
sequence_length
207
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18094055}; Lipid-anchor {ECO:0000269|PubMed:18094055}; Cytoplasmic side {ECO:0000269|PubMed:18094055}. Golgi apparatus {ECO:0000250|UniProtKB:P61006}. Endosome membrane {ECO:0000250|UniProtKB:P61006}. Recycling endosome membrane {ECO:0000269|PubMed:18094055}. Cell projection, cilium {ECO:0000269|PubMed:25860027}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:P61006}; Lipid-anchor {ECO:0000250|UniProtKB:P61006}; Cytoplasmic side {ECO:0000250|UniProtKB:P61006}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23807208}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:19625297, ECO:0000269|PubMed:23807208, ECO:0000269|PubMed:25860027}. Midbody {ECO:0000250|UniProtKB:P61006}. Cytoplasm {ECO:0000250|UniProtKB:P61006}. Lysosome {ECO:0000269|PubMed:30209220}. Note=Colocalizes with OPTN at the Golgi complex and in vesicular structures close to the plasma membrane. In the GDP-bound form, present in the perinuclear region. Shows a polarized distribution to distal regions of cell protrusions in the GTP-bound form. Colocalizes with PARD3, PRKCI, EXOC5, OCLN, PODXL and RAB11A in apical membrane initiation sites (AMIS) during the generation of apical surface and lumenogenesis. Localizes to tubular recycling endosome. Recruited to phagosomes containing S.aureus or Mycobacterium (By similarity). Non-phosphorylated RAB8A predominantly localizes to the cytoplasm whereas phosphorylated RAB8A localizes to the membrane (By similarity). Localizes to enlarged lysosomes through LRRK2 phosphorylation (PubMed:30209220). Colocalizes with RPGR at the primary cilia of epithelial cells (By similarity). {ECO:0000250|UniProtKB:P61006, ECO:0000250|UniProtKB:P61007, ECO:0000269|PubMed:30209220}.
uniprot
proteins