SSH2
entrez
85464
canonical
uniprot
Q76I76
canonical
ensembl
ENSG00000141298
resolver
ensp
ENSP00000269033
resolver
ensp
ENSP00000444743
resolver
ensp
ENSP00000497148
resolver
ensp
ENSP00000497894
resolver
ensp
ENSP00000679748
resolver
ensp
ENSP00000757261
resolver
enst
ENST00000324677
resolver
enst
ENST00000540801
resolver
genesymbol
SSH2
resolver
genesymbol_syn
KIAA1725
resolver
genesymbol_syn
SSH2L
resolver
hgnc
HGNC:30580
resolver
uniprot
A0A3B3ITS1
resolver
uniprot
B4DK64
resolver
uniprot
F5H527
resolver
uniprot
Q8TDB5
resolver
uniprot
Q8WYL1
resolver
uniprot
Q8WYL2
resolver
uniprot
Q96F40
resolver
uniprot
Q96H36
resolver
uniprot
Q9C0D8
resolver
uniprot_entry
A0A3B3ITS1_HUMAN
resolver
uniprot_entry
B4DK64_HUMAN
resolver
uniprot_entry
F5H527_HUMAN
resolver
uniprot_entry
SSH2_HUMAN
resolver
uniprot_sec
Q8TDB5
resolver
uniprot_sec
Q8WYL1
resolver
uniprot_sec
Q8WYL2
resolver
uniprot_sec
Q96F40
resolver
uniprot_sec
Q96H36
resolver
uniprot_sec
Q9C0D8
resolver
amino_acid_sequence
MALVTVQRSPTPSTTSSPCASEADSGEEECRSQPRSISESFLTVKGAALFLPRGNGSSTPRISHRRNKHAGDLQQHLQAMFILLRPEDNIRLAVRLESTYQNRTRYMVVVSTNGRQDTEESIVLGMDFSSNDSSTCTMGLVLPLWSDTLIHLDGDGGFSVSTDNRVHIFKPVSVQAMWSALQSLHKACEVARAHNYYPGSLFLTWVSYYESHINSDQSSVNEWNAMQDVQSHRPDSPALFTDIPTERERTERLIKTKLREIMMQKDLENITSKEIRTELEMQMVCNLREFKEFIDNEMIVILGQMDSPTQIFEHVFLGSEWNASNLEDLQNRGVRYILNVTREIDNFFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIAYAMKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQGILLASKQRHNKLWRSHSDSDLSDHHEPICKPGLELNKKDITTSADQIAEVKTMESHPPIPPVFVEHMVPQDANQKGLCTKERMICLEFTSREFHAGQIEDELNLNDINGCSSGCCLNESKFPLDNCHASKALIQPGHVPEMANKFPDLTVEDLETDALKADMNVHLLPMEELTSPLKDPPMSPDPESPSPQPSCQTEISDFSTDRIDFFSALEKFVELSQETRSRSFSHSRMEELGGGRNESCRLSVVEVAPSKVTADDQRSSSLSNTPHASEESSMDEEQSKAISELVSPDIFMQSHSENAISVKEIVTEIESISQGVGQIQLKGDILPNPCHTPKKNSIHELLLERAQTPENKPGHMEQDEDSCTAQPELAKDSGMCNPEGCLTTHSSIADLEEGEPAEGEQELQGSGMHPGAKWYPGSVRRATLEFEERLRQEQEHHGAAPTCTSLSTRKNSKNDSSVADLAPKGKSDEAPPEHSFVLKEPEMSKGKGKYSGSEAGSLSHSEQNATVPAPRVLEFDHLPDPQEGPGSDTGTQQEGVLKDLRTVIPYQESETQAVPLPLPKRVEIIEYTHIVTSPNHTGPGSEIATSEKSGEQGLRKVNMEKSVTVLCTLDENLNRTLDPNQVSLHPQVLPLPHSSSPEHNRPTDHPTSILSSPEDRGSSLSTALETAAPFVSHTTHLLSASLDYLHPQTMVHLEGFTEQSSTTDEPSAEQVSWEESQESPLSSGSEVPYKDSQLSSADLSLISKLGDNTGELQEKMDPLPVACRLPHSSSSENIKSLSHSPGVVKERAKEIESRVVFQAGLTKPSQMRRSASLAKLGYLDLCKDCLPEREPASCESPHLKLLQPFLRTDSGMHAMEDQESLENPGAPHNPEPTKSFVEQLTTTECIVQSKPVERPLVQYAKEFGSSQQYLLPRAGLELTSSEGGLPVLQTQGLQCACPAPGLAVAPRQQHGRTHPLRRLKKANDKKRTTNPFYNTM
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein (PubMed:11832213). Required for spermatogenesis (By similarity). Involved in acrosome biogenesis, probably by regulating cofilin-mediated actin cytoskeleton remodeling during proacrosomal vesicle fusion and/or Golgi to perinuclear vesicle trafficking (By similarity). {ECO:0000250|UniProtKB:Q5SW75, ECO:0000269|PubMed:11832213}.
uniprot
proteins
mass_dalton
158216
uniprot
proteins
mutagenesis
MUTAGEN 392; /note="C->S: Abrogates phosphatase activity."; /evidence="ECO:0000269|PubMed:11832213
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
11214970
uniprot
proteins
pubmed
11832213
uniprot
proteins
pubmed
14527359
uniprot
proteins
pubmed
14531860
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17427953
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
1423
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5SW75}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q5SW75}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q5SW75}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q5SW75}. Note=Colocalizes with filamentous actin in the cytoplasm and the cell periphery. {ECO:0000250|UniProtKB:Q5SW75}.
uniprot
proteins