Cdk16
entrez
81741
canonical
uniprot
Q63686
canonical
ensembl
ENSRNOG00000008578
resolver
ensembl
ENSRNOG00055016477
resolver
ensembl
ENSRNOG00060020982
resolver
ensembl
ENSRNOG00065020344
resolver
ensp
ENSRNOP00000011592
resolver
ensp
ENSRNOP00055022480
resolver
ensp
ENSRNOP00060030092
resolver
ensp
ENSRNOP00065027545
resolver
enst
ENSRNOT00000011592
resolver
enst
ENSRNOT00055027959
resolver
enst
ENSRNOT00060036565
resolver
enst
ENSRNOT00065034393
resolver
genesymbol
Cdk16
resolver
genesymbol_syn
Pctaire1
resolver
genesymbol_syn
Pctk1
resolver
uniprot
A0A8J8YEJ1
resolver
uniprot
A0A9K3Y885
resolver
uniprot
Q63687
resolver
uniprot_entry
A0A8J8YEJ1_RAT
resolver
uniprot_entry
CDK16_RAT
resolver
uniprot_sec
A0A9K3Y885
resolver
uniprot_sec
Q63687
resolver
amino_acid_sequence
MDRMKKIKRQLSMTLRGGRGIDKTNGVPEQIGLDESGGGGGSDLGEAPTRVAPGELRSIRGPLSSAPEIVHEDMKMGSDGESDQASATSSDEVQSPVRVRMRNHPPRKISTEDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLSRRLRRVSLSEIGFGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDCGNVINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGSTVEEQLHFIFRILGTPTEDTWPGILSNEEFRTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEVQLQKEANIRSTSMPDSGRPAFRVVDTEF
uniprot
proteins
ec_number
2.7.11.22
uniprot
proteins
function
FUNCTION: Protein kinase that plays a role in vesicle-mediated transport processes and exocytosis. Can phosphorylate CCNY at 'Ser-336' (in vitro) Plays a role in the regulation of insulin secretion in response to changes in blood glucose levels. Regulates GH1 release by brain neurons. Required for normal spermatogenesis. Regulates neuron differentiation and dendrite development (By similarity). Phosphorylates NSF, and thereby regulates NSF oligomerization. {ECO:0000250, ECO:0000269|PubMed:16461345}.
uniprot
proteins
mass_dalton
55875
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of CDK16 is essential for the binding of CCNY, but also essential for the regulation of CDK16 kinase activity (By similarity). Phosphorylation of CDK16 is essential for the binding of CCNYl1, but also essential for the regulation of CDK16 kinase activity. Ser-146 and Ser-153 are the most critical sites for the binding of CCNYL1 and for modulating CDK16 kinase activity (By similarity). Phosphorylation at Ser-153 inhibits kinase activity (By similarity). {ECO:0000250|UniProtKB:Q00536, ECO:0000250|UniProtKB:Q04735}.
uniprot
proteins
protein_family
CDC2/CDKX subfamily
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10727952
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16461345
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8918260
uniprot
proteins
sequence_length
496
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q00536}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:16461345}. Cell membrane {ECO:0000250|UniProtKB:Q00536}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q00536}; Cytoplasmic side {ECO:0000250|UniProtKB:Q00536}. Synapse, synaptosome {ECO:0000269|PubMed:16461345}. Note=Colocalizes with insulin in pancreas islets. Recruited to the cell membrane by CCNY. {ECO:0000250|UniProtKB:Q00536}.
uniprot
proteins