Smpd5
entrez
100503915
canonical
uniprot
D6MZJ6
canonical
ensembl
ENSMUSG00000071724
resolver
ensp
ENSMUSP00000134687
resolver
enst
ENSMUST00000163991
resolver
genesymbol
Smpd5
resolver
genesymbol_syn
Gm10345
resolver
uniprot_entry
NSMA5_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Activated by anionic phospholipids, especially cardiolipin and phosphatidylserine. {ECO:0000269|PubMed:20378533}.
uniprot
proteins
amino_acid_sequence
MSLPDISRRRSPVPQEDWPLTPNALRPSPFPNPVLQALYSLSRVLLFPTYWSLDQLLGCWAPSVRSKSLGWFKVLAGSGVLLPLVVVGLPLALVGLALWLPLQVWRRPFCYQPPPACWVWPQPWHPPAERRRCFVFLTANLCLLPHGLAHFNNLSHSLQRAEAVGAALLDSLQSSQYRVSECSQPPPRVPGGELKATLPMGLDFVCLQEVFDLRAARRLVRVLVPNLGPVIYDVGTFGLMAGPYIKVLGSGLLLASRYPLLRATFRCFPNARREDAMASKGLLSVQAQLGIVDGHPIVGYLHCTHLHAPVEDGHIRCKQLTLLLEWVEEFEAENRQSDEAVAFSVLLGDLNFDNCSQDHAKEQGHKLFSCFQDPCRLGVCQEQPWALGTILNSSMLRHSIACSPEMLRRALRQEKGRRLYLSGPLHGSYPAQSWKGRRLDYITYRRVPGSRLSPEAEQVTFSTAFAGLTDHLAMGLKLQVVCS
uniprot
proteins
ec_number
3.1.4.12
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. {ECO:0000250|UniProtKB:F1QG30}.
uniprot
proteins
mass_dalton
53869
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; sphingolipid metabolism. {ECO:0000269|PubMed:20378533}.
uniprot
proteins
protein_family
Neutral sphingomyelinase family
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20378533
uniprot
proteins
sequence_length
483
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:20378533}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:F1QG30}; Intermembrane side {ECO:0000250|UniProtKB:F1QG30}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20378533}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 80..100; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins