Skor2
entrez
664805
canonical
uniprot
A7M7C7
canonical
ensembl
ENSMUSG00000091519
resolver
ensp
ENSMUSP00000132338
resolver
enst
ENSMUST00000166956
resolver
genesymbol
Skor2
resolver
genesymbol_syn
Corl2
resolver
uniprot_entry
SKOR2_MOUSE
resolver
amino_acid_sequence
MASSPLPGPNDILLASPSSAFQPDALSQPRPGHANLKPNQVGQVILYGIPIVSLVIDGQERLCLAQISNTLLKNFSYNEIHNRRVALGITCVQCTPVQLEILRRAGAMPISSRRCGMITKREAERLCKSFLGENRPPKLPDNFAFDVSHECAWGCRGSFIPARYNSSRAKCIKCSYCNMYFSPNKFIFHSHRTPDAKYTQPDAANFNSWRRHLKLTDKSPQDELVFAWEDVKAMFNGGSRKRALPQPSAHPACHPLSSVKAAAVAAAAAVAGGGGLLGPHLLGAPPPPPPPPPLAELAGAPHAHHKRPRFDDDDDSLQEAAVVAAASLSAAAASLSVAAATGGAGPGAGGPGGGCVAGVGVGASAGAGAAAGTKGPRSYPVIPVPSKGSFGGVLQKFPGCGGLFPHPYTFPAAAAAFGLCHKKEDAGTAAEALGGAGAGSAGAAPKAGLSGLFWPAGRKDAFYPPFCMFWPPRTPGGLPVPTYLQPPPQPPSALGCALGDSPALLRQAFLDLAEPGGAGGSAEAAPPPGQPPPVVANGPGSGPPATGGTGARDTLFESPPGGSGGDCSAGSTPPAEQGVTSGTGSASSGAGSVGTRVPAPHHPHLLEGRKAGGGSYHHSSAFRPVGGKDDAESLAKLHGASAGTPHSAPAHHHHHHHHPHHHHHHPPQPPSPLLLLQPQPDEPGSERHHPAPPPPPPPPPLAPQPHHRGLLSPEGTSCSYPSEDSSEDEEDEEEEQEVDVEGHKPLEGEEEEDGRDPEDEEEEDEETRVLLGDSLVGGGRFLQGRGLSEKGSGRDRTTPAVGAFPLALNSSRLLQEDGKLGDSGGSDLPAPPPPPLAPQKASSSGGSRPGSPVHHPSLEEEPSYKDNQKPKENNQVIISTKDDNFSDKNKGHGFFITDSDSSGDFWRERSGEHTQETNSPHSLKKDVENMGKEELQKVLFEQIDLRRRLEQEFQVLKGNTSFPVFNNFQDQMKRELAYREEMVQQLQIIPYAASLIRKEKLGAHLSKS
uniprot
proteins
function
FUNCTION: Has transcriptional corepressor activity (PubMed:18522874, PubMed:21937600). In the developing cerebellum, it down-regulates BMP signaling resulting in up-regulation of SHH expression in Purkinje cells and promoting their early differentiation (PubMed:21937600, PubMed:24491816). It is also involved in regulating the proliferation of cerebellar granule cell precursors (PubMed:21937600). {ECO:0000269|PubMed:18522874, ECO:0000269|PubMed:21937600, ECO:0000269|PubMed:24491816}.
uniprot
proteins
mass_dalton
105616
uniprot
proteins
protein_family
SKI family
uniprot
proteins
pubmed
16200078
uniprot
proteins
pubmed
18522874
uniprot
proteins
pubmed
21937600
uniprot
proteins
pubmed
24491816
uniprot
proteins
sequence_length
1008
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18522874, ECO:0000269|PubMed:21937600}. Cytoplasm {ECO:0000250|UniProtKB:Q2VWA4}.
uniprot
proteins