H2bc1
entrez
24829
canonical
uniprot
Q00729
canonical
ensembl
ENSRNOG00000084925
resolver
ensembl
ENSRNOG00055005449
resolver
ensembl
ENSRNOG00060014901
resolver
ensembl
ENSRNOG00065023038
resolver
ensp
ENSRNOP00000107663
resolver
ensp
ENSRNOP00055006660
resolver
ensp
ENSRNOP00060020315
resolver
ensp
ENSRNOP00065031999
resolver
enst
ENSRNOT00000165789
resolver
enst
ENSRNOT00055008766
resolver
enst
ENSRNOT00060025482
resolver
enst
ENSRNOT00065039369
resolver
genesymbol
H2bc1
resolver
genesymbol_syn
Hist1h2ba
resolver
genesymbol_syn
Th2b
resolver
uniprot
Q64677
resolver
uniprot_entry
H2B1A_RAT
resolver
uniprot_sec
Q64677
resolver
amino_acid_sequence
MPEVSAKGTTISKKGFKKAVTKTQKKEGRKRKRCRKESYSIYIYKVLKQVHPDTGISSKAMSIMNSFVTDIFERIAGEASRLAHYNKRSTITSREIQTAVRLLLPGELAKHAVSEGTKAVTKYTSSK
uniprot
proteins
function
FUNCTION: Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. {ECO:0000250|UniProtKB:P70696}.
uniprot
proteins
mass_dalton
14225
uniprot
proteins
post_translational_modification
PTM: Monoubiquitination at Lys-36 by the MSL1/MSL2 dimer is required for histone H3 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) methylation and transcription activation at specific gene loci, such as HOXA9 and MEIS1 loci. Similarly, monoubiquitination of Lys-122 (H2BK120Ub) by the RNF20/40 complex gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation. It also functions cooperatively with the FACT dimer to stimulate elongation by RNA polymerase II. H2BK120Ub also acts as a regulator of mRNA splicing: deubiquitination by USP49 is required for efficient cotranscriptional splicing of a large set of exons (By similarity). {ECO:0000250|UniProtKB:Q96A08}.; PTM: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes (By similarity). {ECO:0000250|UniProtKB:P70696}.; PTM: Acetylated during spermatogenesis. Acetylated form is most abundant in spermatogonia compared to spermatocytes and round spermatids. {ECO:0000269|PubMed:16283522, ECO:0000269|PubMed:19346237}.; PTM: Phosphorylated at Thr-117 in spermatogonia, spermatocytes and round spermatids. {ECO:0000269|PubMed:19346237}.; PTM: Methylated at Lys-118 in spermatogonia, spermatocytes and round spermatids. {ECO:0000269|PubMed:19346237}.; PTM: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. {ECO:0000250|UniProtKB:P33778}.
uniprot
proteins
protein_family
Histone H2B family
uniprot
proteins
pubmed
16283522
uniprot
proteins
pubmed
19346237
uniprot
proteins
pubmed
2011515
uniprot
proteins
pubmed
2725487
uniprot
proteins
pubmed
3666307
uniprot
proteins
sequence_length
127
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P70696}. Chromosome {ECO:0000250|UniProtKB:P70696}.
uniprot
proteins