PATL1
entrez
219988
canonical
uniprot
Q86TB9
canonical
ensembl
ENSG00000166889
resolver
ensp
ENSP00000300146
resolver
genesymbol
PATL1
resolver
hgnc
HGNC:26721
resolver
uniprot
B3KXT9
resolver
uniprot
Q2TA86
resolver
uniprot
Q6P166
resolver
uniprot
Q8N9M6
resolver
uniprot
Q8NI63
resolver
uniprot_entry
PATL1_HUMAN
resolver
uniprot_sec
B3KXT9
resolver
uniprot_sec
Q2TA86
resolver
uniprot_sec
Q6P166
resolver
uniprot_sec
Q8N9M6
resolver
uniprot_sec
Q8NI63
resolver
amino_acid_sequence
MFRYESLEDCPLDEDEDAFQGLGEEDEEIDQFNDDTFGSGAVDDDWQEAHERLAELEEKLPVAVNEQTGNGERDEMDLLGDHEENLAERLSKMVIENELEDPAIMRAVQTRPVLQPQPGSLNSSIWDGSEVLRRIRGPLLAQEMPTVSVLEYALPQRPPQGPEDDRDLSERALPRRSTSPIIGSPPVRAVPIGTPPKQMAVPSFTQQILCPKPVHVRPPMPPRYPAPYGERMSPNQLCSVPNSSLLGHPFPPSVPPVLSPLQRAQLLGGAQLQPGRMSPSQFARVPGFVGSPLAAMNPKLLQGRVGQMLPPAPGFRAFFSAPPSATPPPQQHPPGPGPHLQNLRSQAPMFRPDTTHLHPQHRRLLHQRQQQNRSQHRNLNGAGDRGSHRSSHQDHLRKDPYANLMLQREKDWVSKIQMMQLQSTDPYLDDFYYQNYFEKLEKLSAAEEIQGDGPKKERTKLITPQVAKLEHAYKPVQFEGSLGKLTVSSVNNPRKMIDAVVTSRSEDDETKEKQVRDKRRKTLVIIEKTYSLLLDVEDYERRYLLSLEEERPALMDDRKHKICSMYDNLRGKLPGQERPSDDHFVQIMCIRKGKRMVARILPFLSTEQAADILMTTARNLPFLIKKDAQDEVLPCLLSPFSLLLYHLPSVSITSLLRQLMNLPQSAATPALSNPHLTAVLQNKFGLSLLLILLSRGEDLQSSDPATESTQNNQWTEVMFMATRELLRIPQAALAKPISIPTNLVSLFSRYVDRQKLNLLETKLQLVQGIR
uniprot
proteins
function
FUNCTION: RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Acts as a scaffold protein that connects deadenylation and decapping machinery (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). Required for cytoplasmic mRNA processing body (P-body) assembly (PubMed:17936923, PubMed:20543818, PubMed:20584987, PubMed:20852261). {ECO:0000269|PubMed:17936923, ECO:0000269|PubMed:20543818, ECO:0000269|PubMed:20584987, ECO:0000269|PubMed:20852261}.; FUNCTION: (Microbial infection) In case of infection, required for translation and replication of hepatitis C virus (HCV). {ECO:0000269|PubMed:19628699}.
uniprot
proteins
mass_dalton
86850
uniprot
proteins
mutagenesis
MUTAGEN 86; /note="L->A: Loss of nuclear export; when associated with A-90, A-93 and A-95."; /evidence="ECO:0000269|PubMed:22090346"; MUTAGEN 90; /note="L->A: Loss of nuclear export; when associated with A-86, A-93 and A-95."; /evidence="ECO:0000269|PubMed:22090346"; MUTAGEN 93; /note="M->A: Loss of nuclear export; when associated with A-86, A-90 and A-95."; /evidence="ECO:0000269|PubMed:22090346"; MUTAGEN 95; /note="I->A: Loss of nuclear export; when associated with A-86, A-90 and A-93."; /evidence="ECO:0000269|PubMed:22090346"; MUTAGEN 519; /note="R->A: In mut1; Abolishes RNA-binding, localization to P-body and interaction with the decapping machinery; when associated with A-520; A-591; A-595; A-625 and A-626."; /evidence="ECO:0000269|PubMed:20543818"; MUTAGEN 520; /note="R->A: In mut1; Abolishes RNA-binding, localization to P-body and interaction with the decapping machinery; when associated with A-519; A-591; A-595; A-625 and A-626."; /evidence="ECO:0000269|PubMed:20543818"; MUTAGEN 523; /note="L->A: In mut2; Abolishes interaction with the decapping machinery and localization to P-body; when associated with A-527; A-530 and S-534."; /evidence="ECO:0000269|PubMed:20543818"; MUTAGEN 527; /note="E->A: In mut2; Abolishes interaction with the decapping machinery and localization to P-body; when associated with S-523; A-530 and S-534."; /evidence="ECO:0000269|PubMed:20543818"; MUTAGEN 530; /note="Y->A: In mut2; Abolishes interaction with the decapping machinery and localization to P-body; when associated with S-523; A-527 and S-534."; /evidence="ECO:0000269|PubMed:20543818"; MUTAGEN 534; /note="L->S: In mut2; Abolishes interaction with the decapping machinery and localization to P-body; when associated with S-523; A-527 and A-530."; /evidence="ECO:0000269|PubMed:20543818"; MUTAGEN 539..557; /note="YERRYLLSLEEERPALMDD->GSGSGSG: In mut3; does not affect neither RNA-binding,interaction with the decapping machinery, nor localization to P-body."; /evidence="ECO:0000269|PubMed:20543818"; MUTAGEN 591; /note="R->A: In mut1; Abolishes RNA-binding, localization to P-body and interaction with the decapping machinery; when associated with A-519; A-520; A-595; A-625 and A-626."; /evidence="ECO:0000269|PubMed:20543818"; MUTAGEN 595; /note="R->A: In mut1; Abolishes RNA-binding, localization to P-body and interaction with the decapping machinery; when associated with A-519; A-520; A-591; A-625 and A-626."; /evidence="ECO:0000269|PubMed:20543818"; MUTAGEN 625; /note="K->A: In mut1; Abolishes RNA-binding, localization to P-body and interaction with the decapping machinery; when associated with A-519; A-520; A-591; A-595 and A-626."; /evidence="ECO:0000269|PubMed:20543818"; MUTAGEN 626; /note="K->A: In mut1; Abolishes RNA-binding, localization to P-body and interaction with the decapping machinery; when associated with A-519; A-520; A-591; A-595 and A-625."; /evidence="ECO:0000269|PubMed:20543818
uniprot
proteins
protein_family
PAT1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17936923
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19628699
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20543818
uniprot
proteins
pubmed
20584987
uniprot
proteins
pubmed
20826699
uniprot
proteins
pubmed
20852261
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22090346
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26027925
uniprot
proteins
pubmed
31422817
uniprot
proteins
pubmed
31439631
uniprot
proteins
pubmed
31570513
uniprot
proteins
pubmed
32354837
uniprot
proteins
sequence_length
770
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:17936923, ECO:0000269|PubMed:20543818, ECO:0000269|PubMed:20584987, ECO:0000269|PubMed:20826699, ECO:0000269|PubMed:20852261, ECO:0000269|PubMed:22090346, ECO:0000269|PubMed:32354837}. Nucleus {ECO:0000269|PubMed:22090346}. Nucleus, PML body {ECO:0000269|PubMed:22090346}. Nucleus speckle {ECO:0000269|PubMed:22090346}. Note=Predominantly cytoplasmic (PubMed:22090346). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner (PubMed:22090346). Enriched in splicing speckles. Localization to nuclear foci and speckles requires active transcription. Excluded from the nucleolus (PubMed:22090346). {ECO:0000269|PubMed:22090346}.
uniprot
proteins