Bmp6
entrez
12161
canonical
uniprot
P20722
canonical
ensembl
ENSMUSG00000039004
resolver
ensp
ENSMUSP00000126999
resolver
enst
ENSMUST00000171970
resolver
genesymbol
Bmp6
resolver
genesymbol_syn
Bmp-6
resolver
genesymbol_syn
Vgr1
resolver
uniprot
B2RRV6
resolver
uniprot
Q3UXB2
resolver
uniprot
Q8BRW3
resolver
uniprot_entry
BMP6_MOUSE
resolver
uniprot_entry
Q3UXB2_MOUSE
resolver
uniprot_entry
Q8BRW3_MOUSE
resolver
uniprot_sec
B2RRV6
resolver
amino_acid_sequence
MPGLGRRAQWLCWWWGLLCSCGPPPLRPPLPVAAAAAGGQLLGAGGSPVRAEQPPPQSSSSGFLYRRLKTHEKREMQKEILSVLGLPHRPRPLHGLQQPQPPVLPPQQQQQQQQQQTAREEPPPGRLKSAPLFMLDLYNALSNDDEEDGASEGVGQEPGSHGGASSSQLRQPSPGAAHSLNRKSLLAPGPGGGASPLTSAQDSAFLNDADMVMSFVNLVEYDKEFSPHQRHHKEFKFNLSQIPEGEAVTAAEFRVYKDCVVGSFKNQTFLISIYQVLQEHQHRDSDLFLLDTRVVWASEEGWLEFDITATSNLWVVTPQHNMGLQLSVVTRDGLHVNPRAAGLVGRDGPYDKQPFMVAFFKVSEVHVRTTRSASSRRRQQSRNRSTQSQDVSRGSGSSDYNGSELKTACKKHELYVSFQDLGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMNPEYVPKPCCAPTKLNAISVLYFDDNSNVILKKYRNMVVRACGCH
uniprot
proteins
function
FUNCTION: Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation (By similarity). Also plays an important role in the regulation of HAMP/hepcidin expression and iron metabolism by acting as a ligand for hemojuvelin/HJV (PubMed:19252486). Also acts to promote expression of HAMP, potentially via the interaction with its receptor BMPR1A/ALK3 (PubMed:31800957). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. Can also signal through non-canonical pathway such as TAZ-Hippo signaling cascade to modulate VEGF signaling by regulating VEGFR2 expression (By similarity). {ECO:0000250|UniProtKB:P22004, ECO:0000269|PubMed:19252486, ECO:0000269|PubMed:31800957}.
uniprot
proteins
mass_dalton
56432
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
14623234
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19252486
uniprot
proteins
pubmed
2734307
uniprot
proteins
pubmed
30097509
uniprot
proteins
pubmed
31800957
uniprot
proteins
pubmed
32464486
uniprot
proteins
pubmed
8089189
uniprot
proteins
pubmed
9069123
uniprot
proteins
pubmed
9664685
uniprot
proteins
sequence_length
510
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P22004}.
uniprot
proteins