Capzb
entrez
298584
canonical
uniprot
Q5XI32
canonical
ensembl
ENSRNOG00000007330
resolver
ensp
ENSRNOP00000010308
resolver
ensp
ENSRNOP00000085427
resolver
ensp
ENSRNOP00000090455
resolver
ensp
ENSRNOP00000092834
resolver
ensp
ENSRNOP00000093194
resolver
enst
ENSRNOT00000099328
resolver
enst
ENSRNOT00000100786
resolver
enst
ENSRNOT00000104673
resolver
enst
ENSRNOT00000118044
resolver
genesymbol
Capzb
resolver
uniprot
A0A8I6A3B7
resolver
uniprot
A0A8I6AWP4
resolver
uniprot
A0A8I6GIW5
resolver
uniprot_entry
A0A8I6A3B7_RAT
resolver
uniprot_entry
A0A8I6AWP4_RAT
resolver
uniprot_entry
A0A8I6GIW5_RAT
resolver
uniprot_entry
CAPZB_RAT
resolver
amino_acid_sequence
MSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCEDLLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGFAGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVEDMENKIRSTLNEIYFGKTKDIVNGLRSVQTFADKSKQEALKNDLVEALKRKQQC
uniprot
proteins
function
FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A9XFX6, ECO:0000250|UniProtKB:P47756}.
uniprot
proteins
mass_dalton
30629
uniprot
proteins
protein_family
F-actin-capping protein beta subunit family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19343716
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
272
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19343716}. Cytoplasm, myofibril, sarcomere {ECO:0000305}.
uniprot
proteins