NUBP1
entrez
4682
canonical
uniprot
P53384
canonical
ensembl
ENSG00000103274
resolver
ensp
ENSP00000283027
resolver
ensp
ENSP00000409654
resolver
ensp
ENSP00000751845
resolver
genesymbol
NUBP1
resolver
genesymbol_syn
NBP
resolver
genesymbol_syn
NBP1
resolver
hgnc
HGNC:8041
resolver
uniprot
Q32M30
resolver
uniprot
Q498A9
resolver
uniprot
Q53FS7
resolver
uniprot_entry
NUBP1_HUMAN
resolver
uniprot_sec
Q32M30
resolver
uniprot_sec
Q498A9
resolver
uniprot_sec
Q53FS7
resolver
amino_acid_sequence
MEEVPHDCPGADSAQAGRGASCQGCPNQRLCASGAGATPDTAIEEIKEKMKTVKHKILVLSGKGGVGKSTFSAHLAHGLAEDENTQIALLDIDICGPSIPKIMGLEGEQVHQSGSGWSPVYVEDNLGVMSVGFLLSSPDDAVIWRGPKKNGMIKQFLRDVDWGEVDYLIVDTPPGTSDEHLSVVRYLATAHIDGAVIITTPQEVSLQDVRKEINFCRKVKLPIIGVVENMSGFICPKCKKESQIFPPTTGGAELMCQDLEVPLLGRVPLDPLIGKNCDKGQSFFIDAPDSPATLAYRSIIQRIQEFCNLHQSKEENLISS
uniprot
proteins
function
FUNCTION: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery (PubMed:18573874). Required for maturation of extramitochondrial Fe-S proteins (PubMed:18573874). The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (PubMed:18573874). Implicated in the regulation of centrosome duplication (By similarity). Negatively regulates cilium formation and structure (By similarity). {ECO:0000250|UniProtKB:Q9R060, ECO:0000269|PubMed:18573874}.
uniprot
proteins
mass_dalton
34534
uniprot
proteins
protein_family
Mrp/NBP35 ATP-binding proteins family
uniprot
proteins
protein_family
NUBP1/NBP35 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18573874
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
29848660
uniprot
proteins
pubmed
7926816
uniprot
proteins
sequence_length
320
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03038, ECO:0000269|PubMed:18573874, ECO:0000269|PubMed:29848660}. Nucleus {ECO:0000250|UniProtKB:Q9R060}. Cell projection {ECO:0000250|UniProtKB:Q9R060}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q9R060}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9R060}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000250|UniProtKB:Q9R060}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q9R060}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Enriched in centrioles of microtubule asters during prophase, prometaphase and telophase stages of mitosis. Localized at centrioles and in the nucleus at interphase. Colocalizes with nubp-2 at prometaphase. Specifically localizes to the axenome of motile cilia as opposed to primary non-motile cilia. Localization is independent of NUBP2 and KIFC1. {ECO:0000250|UniProtKB:Q9R060}.
uniprot
proteins