Sike1
entrez
362007
canonical
uniprot
Q5FWT9
canonical
ensembl
ENSRNOG00000017502
resolver
ensp
ENSRNOP00000024270
resolver
enst
ENSRNOT00000024270
resolver
genesymbol
Sike1
resolver
genesymbol_syn
Sike
resolver
uniprot_entry
SIKE1_RAT
resolver
amino_acid_sequence
MSCTIEKILTDAKTLLERLREHDAAAESLVDQSAALHRRVAAMREAGAVLPEQYQEDASDVKDMSKYKPHILLSQENTQIRDLQQENRELWVSLEEHQDALELIMSKYRKQMLQLMVAKQAVDAEPVLKAHQSHSAEIESQIDRICEMGAVMRRAVQVDDNQFCKIQEKLAQLELENKELRELLSISSESLQVGKESSVAPEAQTIR
uniprot
proteins
function
FUNCTION: Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and RIGI. Does not inhibit NF-kappa-B activation pathways. Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex. The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth. {ECO:0000250|UniProtKB:Q9BRV8}.
uniprot
proteins
mass_dalton
23578
uniprot
proteins
protein_family
SIKE family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
207
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BRV8}.
uniprot
proteins