TRIM71
entrez
131405
canonical
uniprot
Q2Q1W2
canonical
ensembl
ENSG00000206557
resolver
ensembl
ENSG00000291501
resolver
ensp
ENSP00000373272
resolver
ensp
ENSP00000516963
resolver
enst
ENST00000383763
resolver
enst
ENST00000707739
resolver
genesymbol
TRIM71
resolver
genesymbol_syn
LIN41
resolver
hgnc
HGNC:32669
resolver
uniprot_entry
LIN41_HUMAN
resolver
amino_acid_sequence
MASFPETDFQICLLCKEMCGSPAPLSSNSSASSSSSQTSTSSGGGGGGPGAAARRLHVLPCLHAFCRPCLEAHRLPAAGGGAAGEPLKLRCPVCDQKVVLAEAAGMDALPSSAFLLSNLLDAVVATADEPPPKNGRAGAPAGAGGHSNHRHHAHHAHPRASASAPPLPQAPQPPAPSRSAPGGPAASPSALLLRRPHGCSSCDEGNAASSRCLDCQEHLCDNCVRAHQRVRLTKDHYIERGPPGPGAAAAAQQLGLGPPFPGPPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPICRECTMGRHGGHSFIYLQEALQDSRALTIQLLADAQQGRQAIQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALEERECELLWKVEKIRQVKAKSLYLQVEKLRQNLNKLESTISAVQQVLEEGRALDILLARDRMLAQVQELKTVRSLLQPQEDDRVMFTPPDQALYLAIKSFGFVSSGAFAPLTKATGDGLKRALQGKVASFTVIGYDHDGEPRLSGGDLMSAVVLGPDGNLFGAEVSDQQNGTYVVSYRPQLEGEHLVSVTLCNQHIENSPFKVVVKSGRSYVGIGLPGLSFGSEGDSDGKLCRPWGVSVDKEGYIIVADRSNNRIQVFKPCGAFHHKFGTLGSRPGQFDRPAGVACDASRRIVVADKDNHRIQIFTFEGQFLLKFGEKGTKNGQFNYPWDVAVNSEGKILVSDTRNHRIQLFGPDGVFLNKYGFEGALWKHFDSPRGVAFNHEGHLVVTDFNNHRLLVIHPDCQSARFLGSEGTGNGQFLRPQGVAVDQEGRIIVADSRNHRVQMFESNGSFLCKFGAQGSGFGQMDRPSGIAITPDGMIVVVDFGNNRILVF
uniprot
proteins
disease_involvement
DISEASE: Hydrocephalus, congenital, 4 (HYC4) [MIM:618667]: An autosomal dominant form of congenital hydrocephalus, a disease characterized by in utero onset of enlarged ventricles due to accumulation of ventricular cerebrospinal fluid. HYC4 occurs in the absence of obstruction to cerebrospinal fluid flow between the ventricles (communicating hydrocephalus). Affected individuals have neurodevelopmental delay and epilepsy. {ECO:0000269|PubMed:29983323}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (Probable). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A (By similarity). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism (PubMed:23125361). Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity). Specific regulator of miRNA biogenesis. Binds to miRNA MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression (PubMed:28431233). {ECO:0000250|UniProtKB:Q1PSW8, ECO:0000269|PubMed:23125361, ECO:0000269|PubMed:28431233, ECO:0000305|PubMed:24239284}.
uniprot
proteins
mass_dalton
93385
uniprot
proteins
mutagenesis
MUTAGEN 647; /note="G->D: Strongly decreases repression on mRNA."; /evidence="ECO:0000269|PubMed:23125361"; MUTAGEN 675; /note="H->L: Abolishes repression on mRNA. Abolishes interaction with AGO2, PABPC1 and PUM2. Increases interaction with HSP90AA1."; /evidence="ECO:0000269|PubMed:23125361"; MUTAGEN 702; /note="Y->A: Decreases repression on mRNA. Decreases interaction with HSP90AA1. Abolishes interaction with PABPC1 and PUM2. Increases interaction with AGO2."; /evidence="ECO:0000269|PubMed:23125361"; MUTAGEN 751; /note="R->A: Decreases repression on mRNA. Abolishes interaction with AGO2, HSP90AA1, PABPC1 and PUM2."; /evidence="ECO:0000269|PubMed:23125361
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. {ECO:0000250|UniProtKB:Q1PSW8}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
15722555
uniprot
proteins
pubmed
16245339
uniprot
proteins
pubmed
16247770
uniprot
proteins
pubmed
17890240
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23125361
uniprot
proteins
pubmed
24239284
uniprot
proteins
pubmed
28431233
uniprot
proteins
pubmed
29983323
uniprot
proteins
sequence_length
868
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:23125361, ECO:0000269|PubMed:24239284}.
uniprot
proteins