Clic6
entrez
304081
canonical
uniprot
Q811Q2
canonical
ensembl
ENSRNOG00000026870
resolver
ensp
ENSRNOP00000033206
resolver
enst
ENSRNOT00000034383
resolver
genesymbol
Clic6
resolver
genesymbol_syn
Clic6b
resolver
uniprot
A0A0G2JTB6
resolver
uniprot
F1M9X4
resolver
uniprot_entry
CLIC6_RAT
resolver
uniprot_entry
F1M9X4_RAT
resolver
uniprot_sec
A0A0G2JTB6
resolver
activity_regulation
ACTIVITY REGULATION: Channel activity is redox- and pH-regulated. Inhibited by IAA-94. {ECO:0000250|UniProtKB:Q96NY7}.
uniprot
proteins
amino_acid_sequence
MAEATEPKEVSSGSQGQPEGAVIEGPGEPGAADLEGREASEGAAEAPRDLGEGAEAMASGKEEGGCGQDGEIGEVQAQDPRPGPGTETPGTSGAPGEAEAAECDSEGALIPQSGGGAKRQQVQGTSSGLDAQGEAPEVPEDARREPEDPKASEAGEEAESGQEALGGSAPESQINPEVQGPVGDNMDTEAPAGEPQGSEGEPQGGGESSPQPQDEAIEIAAAEVGGHEPGELAGASAADAKGEGETLRKDGFEEAAPEEARVDSGENGFEEAAPEEARVDSGENRDQGRLQEETGEEEARPESGLKGPCEEAIQEKAPDGSLDGEEAKSTGHEESQVELSNHLAEETSAQGGEELGRVNGRRENGPASEEGDLGQEHDITLFVKAGSDGESIGNCPFSQRLFMILWLKGVIFNVTTVDLKRKPADLQNLAPGTNPPFMTFDGEVKTDVNKIEEFLEEKLVPPRYPKLGTQHPESNSAGNDVFAKFSAFIKNTKKDANDIYEKNLLRALKKLDSYLNSPLPDEIDAYSTEDVTVSQRKFLDGDELTLADCNLLPKLHIIKIVAKKYRGFEFPSEMTGIWRYLNNAYARDEFTNTCPADQEIEHAYSDAAKRMK
uniprot
proteins
ec_number
1.8.-.-
uniprot
proteins
function
FUNCTION: In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (By similarity). Can insert into membranes and form voltage-dependent chloride-selective channels. The channel opens upon membrane depolarization at positive voltages and closes at negative membrane voltages (By similarity). May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity). {ECO:0000250|UniProtKB:Q96NY7, ECO:0000250|UniProtKB:Q9N2G5, ECO:0000250|UniProtKB:Q9Y696}.
uniprot
proteins
mass_dalton
64687
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250|UniProtKB:Q9N2G5}.
uniprot
proteins
protein_family
Chloride channel CLIC family
uniprot
proteins
pubmed
14499480
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
612
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000305|PubMed:14499480}; Single-pass membrane protein {ECO:0000305|PubMed:14499480}. Note=Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane (By similarity). Colocalizes with DRD3 at the plasma membrane. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 397..417; /note="Helical; Note=After insertion into the membrane"; /evidence="ECO:0000255
uniprot
proteins