Ptpre
entrez
19267
canonical
uniprot
P49446
canonical
ensembl
ENSMUSG00000041836
resolver
ensp
ENSMUSP00000073616
resolver
ensp
ENSMUSP00000147313
resolver
ensp
ENSMUSP00000147524
resolver
ensp
ENSMUSP00000147613
resolver
ensp
ENSMUSP00000147656
resolver
enst
ENSMUST00000209256
resolver
enst
ENSMUST00000211788
resolver
genesymbol
Ptpre
resolver
genesymbol_syn
Ptpe
resolver
uniprot
A0A1B0GRH2
resolver
uniprot
A0A1B0GRT6
resolver
uniprot
Q3U369
resolver
uniprot
Q3V1H5
resolver
uniprot
Q60986
resolver
uniprot
Q61042
resolver
uniprot
Q62134
resolver
uniprot
Q62444
resolver
uniprot
Q64496
resolver
uniprot_entry
A0A1B0GRH2_MOUSE
resolver
uniprot_entry
A0A1B0GRT6_MOUSE
resolver
uniprot_entry
PTPRE_MOUSE
resolver
uniprot_entry
Q3V1H5_MOUSE
resolver
uniprot_sec
Q3U369
resolver
uniprot_sec
Q60986
resolver
uniprot_sec
Q61042
resolver
uniprot_sec
Q62134
resolver
uniprot_sec
Q62444
resolver
uniprot_sec
Q64496
resolver
activity_regulation
ACTIVITY REGULATION: [Isoform 1]: Inhibited by alendronate (ALN), orthovanadate, and phenylarsine oxide (PAO). {ECO:0000269|PubMed:8610169}.
uniprot
proteins
amino_acid_sequence
MEPFCPLLLASFSLSLARAGQGNDTTPTESNWTSTTAGPPDPGASQPLLTWLLLPLLLLLFLLAAYFFRFRKQRKAVVSSNDKKMPNGILEEQEQQRVMLLSRSPSGPKKFFPIPVEHLEEEIRVRSADDCKRFREEFNSLPSGHIQGTFELANKEENREKNRYPNILPNDHCRVILSQVDGIPCSDYINASYIDGYKEKNKFIAAQGPKQETVNDFWRMVWEQRSATIVMLTNLKERKEEKCYQYWPDQGCWTYGNIRVCVEDCVVLVDYTIRKFCIHPQLPDSCKAPRLVSQLHFTSWPDFGVPFTPIGMLKFLKKVKTLNPSHAGPIVVHCSAGVGRTGTFIVIDAMMDMIHSEQKVDVFEFVSRIRNQRPQMVQTDVQYTFIYQALLEYYLYGDTELDVSSLERHLQTLHSTATHFDKIGLEEEFRKLTNVRIMKENMRTGNLPANMKKARVIQIIPYDFNRVILSMKRGQEFTDYINASFIDGYRQKDYFMATQGPLAHTVEDFWRMVWEWKSHTIVMLTEVQEREQDKCYQYWPTEGSVTHGDITIEIKSDTLSEAISVRDFLVTFKQPLARQEEQVRMVRQFHFHGWPEVGIPAEGKGMIDLIAAVQKQQQQTGNHPITVHCSAGAGRTGTFIALSNILERVKAEGLLDVFQAVKSLRLQRPHMVQTLEQYEFCYKVVQDFIDIFSDYANFK
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: [Isoform 1]: Acts as a negative regulator of insulin receptor (IR) signaling and is involved in insulin-induced glucose metabolism mainly through direct dephosphorylation and inactivation of IR in hepatocytes and liver (By similarity). Plays a critical role in signaling transduction pathways and phosphoprotein network topology in red blood cells. May play a role in osteoclast formation and function. {ECO:0000250, ECO:0000269|PubMed:19508371, ECO:0000269|PubMed:8610169}.; FUNCTION: [Isoform 2]: Acts as a negative regulator of insulin receptor (IR) signaling in skeletal muscle. Regulates insulin-induced tyrosine phosphorylation of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1), phosphorylation of protein kinase B and glycogen synthase kinase-3 and insulin induced stimulation of glucose uptake.; FUNCTION: Isoform 1 and isoform 2 act as a negative regulator of FceRI-mediated signal transduction leading to cytokine production and degranulation, most likely by acting at the level of SYK to affect downstream events such as phosphorylation of SLP76 and LAT and mobilization of Ca(2+).
uniprot
proteins
mass_dalton
80688
uniprot
proteins
post_translational_modification
PTM: A catalytically active cytoplasmic form (p65) is produced by proteolytic cleavage of either isoform 1, isoform 2 or isoform 3. {ECO:0000269|PubMed:10980613}.; PTM: [Isoform 1]: Phosphorylated on tyrosine residues by tyrosine kinase Neu. {ECO:0000250}.; PTM: [Isoform 2]: Phosphorylated on tyrosine residues by tyrosine kinase Neu. {ECO:0000250}.; PTM: [Isoform 1]: Glycosylated. {ECO:0000250}.
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
protein_family
Receptor class 4 subfamily
uniprot
proteins
pubmed
10980613
uniprot
proteins
pubmed
12861030
uniprot
proteins
pubmed
1454056
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
18006633
uniprot
proteins
pubmed
18924107
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
1932742
uniprot
proteins
pubmed
19508371
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7592814
uniprot
proteins
pubmed
7832766
uniprot
proteins
pubmed
8610169
uniprot
proteins
pubmed
8618876
uniprot
proteins
pubmed
9914474
uniprot
proteins
sequence_length
699
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Note=Predominantly cytoplasmic. A small fraction is also associated with nucleus and membrane. Insulin can induce translocation to the membrane.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm.
uniprot
proteins
transmembrane_region
TRANSMEM 46..68; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins