Incenp
entrez
16319
canonical
uniprot
Q9WU62
canonical
ensembl
ENSMUSG00000024660
resolver
ensp
ENSMUSP00000025562
resolver
ensp
ENSMUSP00000157547
resolver
genesymbol
Incenp
resolver
uniprot
Q7TN28
resolver
uniprot
Q8BGN4
resolver
uniprot
Q8CGI4
resolver
uniprot_entry
INCE_MOUSE
resolver
uniprot_sec
Q7TN28
resolver
uniprot_sec
Q8BGN4
resolver
uniprot_sec
Q8CGI4
resolver
amino_acid_sequence
MGTTAPGPICLLDLCDQKLLDFVCNVDNKDFMWLKEIEEEAERMFIREFSNEPELMPKTPSQKNRRKKRRVSNIQDENRDPVRKRLSRRKSRSSQVGTRHLRSKPVTIVEENGFPVLQRITRATAAAAAAAAAASVASASSSSTAGSPTVLTKKAVVEISTSERLSAELQLTKLKGSLPPSPVSQGTLTSEEELTPKKSEAGKLDSVTVNSLKATPQSPKNRGVGEGRSVSKLKIARASWGLQDSPGSTDSPWQERVLSPILLNNILPTTAKSPLGNIRSVRRSLISQDSQVPLASKYNLVAKQENGSRRSSRRIAKKAGKEPEASARIICHSYLERLLNVEVPQNVGLEQEPVEVAEPEEAEEEQEVSKNSGCPSKPRSATKIAISTPTSKPAAAGQTTTVEEQEAELDQTDGHREPPQSVRRKRSYKQAISEPDEEQLEDEELQPCQNKTPSPPCPANKVVRPLRTFLHTVQKNQMLMTPTLASRSSVMKSFIKRNTPLRVDPKCSFVEKERQRLESLRRKEEAEQRRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEKAKKKATAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQEMLQRKKEEEQERRKAAEARRLAEQREQERRREQERREQERREQERREQERKEQERREQEQERLRAKREMQEREKALRLQKERLQKELEEKKRKEEQQRLAEQQLQEEQAKKAKEVAAARKVLNMTVDVQSPVCTSYQMTPQGPKSIPKISVDDYGMDLNSDDSTDDESHPRKPIPSWAKGTQLSQAIVHQYYHPPNILELFGSILPLDLEDIFKKRKTRYHKRTSSAVWNSPPLKATMVPSSGD
uniprot
proteins
function
FUNCTION: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB or AURKC, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central SAH domain directs AURKB/C toward substrates near microtubules. The flexibility of the SAH domain is proposed to allow AURKB/C to follow substrates on dynamic microtubules while ensuring CPC docking to static chromatin (By similarity). Activates AURKB and AURKC. Controls the kinetochore localization of BUB1. {ECO:0000250|UniProtKB:P53352, ECO:0000250|UniProtKB:Q9NQS7}.
uniprot
proteins
mass_dalton
101209
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by AURKB at its C-terminal part is important for AURKB activation by INCENP. {ECO:0000250}.
uniprot
proteins
protein_family
INCENP family
uniprot
proteins
pubmed
10087305
uniprot
proteins
pubmed
12584241
uniprot
proteins
pubmed
12660166
uniprot
proteins
pubmed
14722118
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
20571061
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
880
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome, centromere {ECO:0000269|PubMed:12584241}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:12584241}. Nucleus {ECO:0000269|PubMed:12584241}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:12584241}. Midbody {ECO:0000250|UniProtKB:Q9NQS7}. Note=Localizes to inner kinetochore. Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes to the equatorial cell cortex at anaphase (By similarity). Localized at synaptonemal complex central element from zygotene up to late pachytene when it begins to relocalize to heterochromatic chromocenters (PubMed:12584241). Colocalizes with AURKB at a connecting strand traversing the centromere region and joining sister kinetochores, in metaphase II centromeres. This strand disappears at the metaphase II/anaphase II transition and relocalizes to the spindle midzone (PubMed:12584241). {ECO:0000250|UniProtKB:Q9NQS7, ECO:0000269|PubMed:12584241}.
uniprot
proteins