Aldh1a1
entrez
11668
canonical
uniprot
P24549
canonical
ensembl
ENSMUSG00000053279
resolver
ensp
ENSMUSP00000084918
resolver
ensp
ENSMUSP00000153410
resolver
ensp
ENSMUSP00000180349
resolver
ensp
ENSMUSP00000180351
resolver
ensp
ENSMUSP00000180354
resolver
enst
ENSMUST00000087638
resolver
enst
ENSMUST00000225337
resolver
genesymbol
Aldh1a1
resolver
genesymbol_syn
Ahd-2
resolver
genesymbol_syn
Ahd2
resolver
genesymbol_syn
Aldh1
resolver
uniprot
Q7TQJ0
resolver
uniprot
Q811J0
resolver
uniprot_entry
AL1A1_MOUSE
resolver
uniprot_sec
Q7TQJ0
resolver
uniprot_sec
Q811J0
resolver
activity_regulation
ACTIVITY REGULATION: The aminobutyraldehyde dehydrogenase activity is negatively regulated by ethanol in vivo. {ECO:0000269|PubMed:26430123}.
uniprot
proteins
amino_acid_sequence
MSSPAQPAVPAPLADLKIQHTKIFINNEWHNSVSGKKFPVLNPATEEVICHVEEGDKADVDKAVKAARQAFQIGSPWRTMDASERGRLLNKLADLMERDRLLLATMEALNGGKVFANAYLSDLGGCIKALKYCAGWADKIHGQTIPSDGDIFTYTRREPIGVCGQIIPWNFPMLMFIWKIGPALSCGNTVVVKPAEQTPLTALHLASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDVDKVAFTGSTQVGKLIKEAAGKSNLKRVTLELGGKSPCIVFADADLDIAVEFAHHGVFYHQGQCCVAASRIFVEESVYDEFVKRSVERAKKYVLGNPLTPGINQGPQIDKEQHDKILDLIESGKKEGAKLECGGGRWGNKGFFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSVDDVIKRANNTTYGLAAGLFTKDLDKAITVSSALQAGVVWVNCYMMLSAQCPFGGFKMSGNGRELGEHGLYEYTELKTVAMKISQKNS
uniprot
proteins
ec_number
1.2.1.19
uniprot
proteins
ec_number
1.2.1.28
uniprot
proteins
ec_number
1.2.1.3
uniprot
proteins
ec_number
1.2.1.36
uniprot
proteins
function
FUNCTION: Cytosolic dehydrogenase that catalyzes the NAD(+)-dependent irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:12851412). Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid (PubMed:12851412). This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (Probable). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification (PubMed:17567582). Also functions downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (By similarity). Also has an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (PubMed:26430123). {ECO:0000250|UniProtKB:P00352, ECO:0000269|PubMed:12851412, ECO:0000269|PubMed:17567582, ECO:0000269|PubMed:26430123, ECO:0000305|PubMed:12851412}.
uniprot
proteins
mass_dalton
54468
uniprot
proteins
pathway_participation
PATHWAY: Cofactor metabolism; retinol metabolism. {ECO:0000269|PubMed:12851412}.
uniprot
proteins
post_translational_modification
PTM: The N-terminus is blocked most probably by acetylation. {ECO:0000250|UniProtKB:P15437}.
uniprot
proteins
protein_family
Aldehyde dehydrogenase family
uniprot
proteins
pubmed
12851412
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17567582
uniprot
proteins
pubmed
1935685
uniprot
proteins
pubmed
2055490
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26430123
uniprot
proteins
pubmed
7993664
uniprot
proteins
sequence_length
501
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:1935685}. Cell projection, axon {ECO:0000269|PubMed:26430123}.
uniprot
proteins