Lfng
entrez
170905
canonical
uniprot
Q924T4
canonical
ensembl
ENSRNOG00000001250
resolver
ensembl
ENSRNOG00055011516
resolver
ensembl
ENSRNOG00060027942
resolver
ensembl
ENSRNOG00065000112
resolver
ensp
ENSRNOP00000086737
resolver
ensp
ENSRNOP00055015793
resolver
ensp
ENSRNOP00060040427
resolver
ensp
ENSRNOP00065000191
resolver
enst
ENSRNOT00000101623
resolver
enst
ENSRNOT00055019573
resolver
enst
ENSRNOT00060048512
resolver
enst
ENSRNOT00065000192
resolver
genesymbol
Lfng
resolver
uniprot_entry
LFNG_RAT
resolver
amino_acid_sequence
MLQRCGRRLLLALVGALLACLLVLTADPPPTPVPAERGRRALRSLAGSSGAAPGPGSRAAVDPGVLVREVHSLSEYFSLLTRARRDADPPPGVASRQGDGHPRPPAEVLSPRDVFIAVKTTRKFHRARLDLLFETWISRHKEMTFIFTDGEDEALAKHTGNVVLTNCSAAHSRQALSCKMAVEYDRFIESGKKWFCHVDDDNYVNLRALLRLLASYPHTQDVYIGKPSLDRPIQATERISEHRVRPVHFWFATGGAGFCISRGLALKMGPWASGGHFMSTAERIRLPDDCTIGYIVEALLGVPLIRSGLFHSHLENLQQVPTTELHEQVTLSYGMFENKRNAVHIKGPFSVEADPSRFRSIHCHLYPDTPWCPRTAIL
uniprot
proteins
ec_number
2.4.1.222
uniprot
proteins
function
FUNCTION: Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1. Decreases the binding of JAG1 to NOTCH2 but not that of DLL1. Essential mediator of somite segmentation and patterning. {ECO:0000250|UniProtKB:O09010, ECO:0000250|UniProtKB:Q8NES3}.
uniprot
proteins
mass_dalton
41958
uniprot
proteins
post_translational_modification
PTM: A soluble form may be derived from the membrane form by proteolytic processing. {ECO:0000305}.
uniprot
proteins
protein_family
Glycosyltransferase 31 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
378
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250|UniProtKB:O09010}. Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins