ARHGEF7
entrez
8874
canonical
uniprot
Q14155
canonical
ensembl
ENSG00000102606
resolver
ensp
ENSP00000218789
resolver
ensp
ENSP00000325994
resolver
ensp
ENSP00000364875
resolver
ensp
ENSP00000364888
resolver
ensp
ENSP00000364891
resolver
ensp
ENSP00000364893
resolver
ensp
ENSP00000397068
resolver
ensp
ENSP00000417596
resolver
ensp
ENSP00000418067
resolver
ensp
ENSP00000495631
resolver
ensp
ENSP00000514984
resolver
ensp
ENSP00000593471
resolver
ensp
ENSP00000749031
resolver
enst
ENST00000218789
resolver
enst
ENST00000478679
resolver
enst
ENST00000646102
resolver
enst
ENST00000700426
resolver
genesymbol
ARHGEF7
resolver
genesymbol_syn
COOL1
resolver
genesymbol_syn
KIAA0142
resolver
genesymbol_syn
P85SPR
resolver
genesymbol_syn
PAK3BP
resolver
genesymbol_syn
PIXB
resolver
hgnc
HGNC:15607
resolver
uniprot
A0A2R8YG42
resolver
uniprot
A0A8V8TQ72
resolver
uniprot
B1ALK6
resolver
uniprot
B1ALK7
resolver
uniprot
B1ALK8
resolver
uniprot
B7Z344
resolver
uniprot
B7Z6G2
resolver
uniprot
E9PDQ5
resolver
uniprot
Q3LIA4
resolver
uniprot
Q5W9H0
resolver
uniprot
Q6P9G3
resolver
uniprot
Q6PII2
resolver
uniprot
Q86W63
resolver
uniprot
Q8N3M1
resolver
uniprot_entry
A0A2R8YG42_HUMAN
resolver
uniprot_entry
A0A8V8TQ72_HUMAN
resolver
uniprot_entry
ARHG7_HUMAN
resolver
uniprot_entry
B1ALK7_HUMAN
resolver
uniprot_entry
B7Z344_HUMAN
resolver
uniprot_entry
B7Z6G2_HUMAN
resolver
uniprot_entry
E9PDQ5_HUMAN
resolver
uniprot_sec
B1ALK6
resolver
uniprot_sec
B1ALK8
resolver
uniprot_sec
Q3LIA4
resolver
uniprot_sec
Q5W9H0
resolver
uniprot_sec
Q6P9G3
resolver
uniprot_sec
Q6PII2
resolver
uniprot_sec
Q86W63
resolver
uniprot_sec
Q8N3M1
resolver
amino_acid_sequence
MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEPRSESECLSNIREFLRGCGASLRLELLFPPSQPPQHLVTTILLSASTFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIWTAHSYRMGSTSRKSCCSYISHQN
uniprot
proteins
function
FUNCTION: Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. {ECO:0000250, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:18716323, ECO:0000269|PubMed:19041750}.
uniprot
proteins
mass_dalton
90012
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PTK2/FAK1; this promotes interaction with RAC1 (By similarity). Phosphorylated on Ser-694 by CaMK1; enhancement of GEF activity and downstream activation of RAC1. {ECO:0000250, ECO:0000269|PubMed:18184567}.
uniprot
proteins
pubmed
12880961
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15182672
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15491607
uniprot
proteins
pubmed
16101281
uniprot
proteins
pubmed
16329988
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18184567
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18716323
uniprot
proteins
pubmed
19041750
uniprot
proteins
pubmed
19118189
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21248752
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21926430
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23285027
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8590280
uniprot
proteins
pubmed
9726964
uniprot
proteins
pubmed
9846881
uniprot
proteins
sequence_length
803
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000250}. Cell projection, ruffle {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Note=Detected at cell adhesions. A small proportion is detected at focal adhesions.
uniprot
proteins