OTUB2
entrez
78990
canonical
uniprot
Q96DC9
canonical
ensembl
ENSG00000089723
resolver
ensembl
ENSG00000277276
resolver
ensp
ENSP00000203664
resolver
genesymbol
OTUB2
resolver
genesymbol_syn
C14orf137
resolver
genesymbol_syn
OTB2
resolver
genesymbol_syn
OTU2
resolver
hgnc
HGNC:20351
resolver
uniprot
Q6IA10
resolver
uniprot
Q9H6T1
resolver
uniprot_entry
OTUB2_HUMAN
resolver
uniprot_sec
Q6IA10
resolver
uniprot_sec
Q9H6T1
resolver
amino_acid_sequence
MSETSFNLISEKCDILSILRDHPENRIYRRKIEELSKRFTAIRKTKGDGNCFYRALGYSYLESLLGKSREIFKFKERVLQTPNDLLAAGFEEHKFRNFFNAFYSVVELVEKDGSVSSLLKVFNDQSASDHIVQFLRLLTSAFIRNRADFFRHFIDEEMDIKDFCTHEVEPMATECDHIQITALSQALSIALQVEYVDEMDTALNHHVFPEAATPSVYLLYKTSHYNILYAADKH
uniprot
proteins
ec_number
3.4.19.12
uniprot
proteins
function
FUNCTION: Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:12704427, ECO:0000269|PubMed:18954305, ECO:0000269|PubMed:23827681}.
uniprot
proteins
mass_dalton
27213
uniprot
proteins
mutagenesis
MUTAGEN 47; /note="G->P: Affects its ability to cleave 'K63'-linked ubiquitin."; /evidence="ECO:0000269|PubMed:18954305"; MUTAGEN 51; /note="C->S: Loss of function in vitro."; /evidence="ECO:0000269|PubMed:12704427"; MUTAGEN 226; /note="N->A: Abolishes deubiquitinase activity."; /evidence="ECO:0000269|PubMed:15258613
uniprot
proteins
protein_family
Peptidase C65 family
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
12704427
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15258613
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18954305
uniprot
proteins
pubmed
23827681
uniprot
proteins
sequence_length
234
uniprot
proteins