SLC2A3
entrez
6515
canonical
uniprot
P11169
canonical
ensembl
ENSG00000059804
resolver
ensp
ENSP00000075120
resolver
ensp
ENSP00000516774
resolver
ensp
ENSP00000520516
resolver
enst
ENST00000075120
resolver
enst
ENST00000707174
resolver
enst
ENST00000715759
resolver
genesymbol
SLC2A3
resolver
genesymbol_syn
GLUT3
resolver
hgnc
HGNC:11007
resolver
uniprot
B2R606
resolver
uniprot
D3DUU6
resolver
uniprot
Q6I9U2
resolver
uniprot
Q9UG15
resolver
uniprot_entry
GTR3_HUMAN
resolver
uniprot_sec
B2R606
resolver
uniprot_sec
D3DUU6
resolver
uniprot_sec
Q6I9U2
resolver
uniprot_sec
Q9UG15
resolver
activity_regulation
ACTIVITY REGULATION: Deoxyglucose transport is inhibited by D-glucose, D-galactose and maltose (PubMed:8457197). Galactose transport is inhibited by D-glucose and maltose (PubMed:8457197). {ECO:0000269|PubMed:8457197}.
uniprot
proteins
amino_acid_sequence
MGTQKVTPALIFAITVATIGSFQFGYNTGVINAPEKIIKEFINKTLTDKGNAPPSEVLLTSLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAVTGGCFMGLCKVAKSVEMLILGRLVIGLFCGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLLLGFTILPAILQSAALPFCPESPRFLLINRKEEENAKQILQRLWGTQDVSQDIQEMKDESARMSQEKQVTVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVQEPIYATIGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSLLLKDNYNGMSFVCIGAILVFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAHYLGAYVFIIFTGFLITFLAFTFFKVPETRGRTFEDITRAFEGQAHGADRSGKDGVMEMNSIEPAKETTTNV
uniprot
proteins
function
FUNCTION: Facilitative glucose transporter (PubMed:26176916, PubMed:32860739, PubMed:9477959). Can also mediate the uptake of various other monosaccharides across the cell membrane (PubMed:26176916, PubMed:9477959). Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate (PubMed:26176916, PubMed:9477959). Does not mediate fructose transport (PubMed:26176916, PubMed:9477959). Required for mesendoderm differentiation (By similarity). {ECO:0000250|UniProtKB:P32037, ECO:0000269|PubMed:26176916, ECO:0000269|PubMed:32860739, ECO:0000269|PubMed:8457197, ECO:0000269|PubMed:9477959}.
uniprot
proteins
mass_dalton
53924
uniprot
proteins
mutagenesis
MUTAGEN 277..279; /note="QLS->HVA: Confers moderate fructose transport activity."; /evidence="ECO:0000269|PubMed:26176916
uniprot
proteins
protein_family
Glucose transporter subfamily
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Sugar transporter (TC 2.A.1.1) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
26176916
uniprot
proteins
pubmed
3170580
uniprot
proteins
pubmed
32860739
uniprot
proteins
pubmed
35810171
uniprot
proteins
pubmed
8457197
uniprot
proteins
pubmed
9477959
uniprot
proteins
sequence_length
496
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9477959, ECO:0000305|PubMed:26176916}; Multi-pass membrane protein {ECO:0000269|PubMed:26176916}. Perikaryon {ECO:0000250|UniProtKB:Q07647}. Cell projection {ECO:0000250|UniProtKB:Q07647}. Note=Localized to densely spaced patches along neuronal processes. {ECO:0000250|UniProtKB:Q07647}.
uniprot
proteins
transmembrane_region
TRANSMEM 11..32; /note="Helical; Name=1"; /evidence="ECO:0000255, ECO:0000269|PubMed:26176916"; TRANSMEM 65..85; /note="Helical; Name=2"; /evidence="ECO:0000255, ECO:0000269|PubMed:26176916"; TRANSMEM 91..111; /note="Helical; Name=3"; /evidence="ECO:0000255, ECO:0000269|PubMed:26176916"; TRANSMEM 119..142; /note="Helical; Name=4"; /evidence="ECO:0000255, ECO:0000269|PubMed:26176916"; TRANSMEM 154..174; /note="Helical; Name=5"; /evidence="ECO:0000255, ECO:0000269|PubMed:26176916"; TRANSMEM 184..204; /note="Helical; Name=6"; /evidence="ECO:0000255, ECO:0000269|PubMed:26176916"; TRANSMEM 270..290; /note="Helical; Name=7"; /evidence="ECO:0000255, ECO:0000269|PubMed:26176916"; TRANSMEM 305..325; /note="Helical; Name=8"; /evidence="ECO:0000255, ECO:0000269|PubMed:26176916"; TRANSMEM 332..352; /note="Helical; Name=9"; /evidence="ECO:0000255, ECO:0000269|PubMed:26176916"; TRANSMEM 364..389; /note="Helical; Name=10"; /evidence="ECO:0000255, ECO:0000269|PubMed:26176916"; TRANSMEM 400..420; /note="Helical; Name=11"; /evidence="ECO:0000255, ECO:0000269|PubMed:26176916"; TRANSMEM 430..450; /note="Helical; Name=12"; /evidence="ECO:0000255, ECO:0000269|PubMed:26176916
uniprot
proteins