Bax
entrez
12028
canonical
uniprot
Q07813
canonical
ensembl
ENSMUSG00000003873
resolver
ensp
ENSMUSP00000033093
resolver
ensp
ENSMUSP00000148240
resolver
ensp
ENSMUSP00000148265
resolver
enst
ENSMUST00000033093
resolver
enst
ENSMUST00000211365
resolver
genesymbol
Bax
resolver
uniprot
A0A1B0GT81
resolver
uniprot
Q544Z6
resolver
uniprot
Q8K3J2
resolver
uniprot_entry
A0A1B0GT81_MOUSE
resolver
uniprot_entry
BAX_MOUSE
resolver
uniprot_entry
Q544Z6_MOUSE
resolver
uniprot_entry
Q8K3J2_MOUSE
resolver
amino_acid_sequence
MDGSGEQLGSGGPTSSEQIMKTGAFLLQGFIQDRAGRMAGETPELTLEQPPQDASTKKLSECLRRIGDELDSNMELQRMIADVDTDSPREVFFRVAADMFADGNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLVWIQDQGGWEGLLSYFGTPTWQTVTIFVAGVLTASLTIWKKMG
uniprot
proteins
function
FUNCTION: Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. BAX deficiency leads to lymphoid hyperplasia and male sterility, because of the cessation of sperm production. {ECO:0000269|PubMed:21060336, ECO:0000269|PubMed:8358790}.
uniprot
proteins
mass_dalton
21395
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated in the absence of XRCC6/Ku70 (By similarity). Ubiquitinated on Lys-128 and Lys-190. 'Lys-63'-linked polyubiquitin chains on Lys-128 are removed by USP12. {ECO:0000250|UniProtKB:Q07812}.
uniprot
proteins
protein_family
Bcl-2 family
uniprot
proteins
pubmed
15383280
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16509771
uniprot
proteins
pubmed
18248095
uniprot
proteins
pubmed
21060336
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8358790
uniprot
proteins
sequence_length
192
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform Alpha]: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q07812}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q07812}. Nucleus {ECO:0000250|UniProtKB:Q07812}. Note=Colocalizes with 14-3-3 proteins in the cytoplasm. Under stress conditions, undergoes a conformation change that causes release from JNK-phosphorylated 14-3-3 proteins and translocation to the mitochondrion membrane (By similarity). {ECO:0000250|UniProtKB:Q07812}.; SUBCELLULAR LOCATION: [Isoform Beta]: Cytoplasm {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform Gamma]: Cytoplasm {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 172..192; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins