RBM47
entrez
54502
canonical
uniprot
A0AV96
canonical
ensembl
ENSG00000163694
resolver
ensp
ENSP00000295971
resolver
ensp
ENSP00000371212
resolver
ensp
ENSP00000371214
resolver
ensp
ENSP00000423243
resolver
ensp
ENSP00000580756
resolver
ensp
ENSP00000580757
resolver
ensp
ENSP00000580762
resolver
ensp
ENSP00000580765
resolver
ensp
ENSP00000580770
resolver
ensp
ENSP00000582959
resolver
ensp
ENSP00000582960
resolver
ensp
ENSP00000582961
resolver
ensp
ENSP00000582964
resolver
ensp
ENSP00000582967
resolver
ensp
ENSP00000582969
resolver
ensp
ENSP00000621014
resolver
ensp
ENSP00000621015
resolver
ensp
ENSP00000658881
resolver
ensp
ENSP00000658882
resolver
ensp
ENSP00000658884
resolver
ensp
ENSP00000694044
resolver
ensp
ENSP00000694045
resolver
enst
ENST00000514014
resolver
genesymbol
RBM47
resolver
hgnc
HGNC:30358
resolver
uniprot
A0PJK2
resolver
uniprot
B5MED4
resolver
uniprot
B7Z8Z7
resolver
uniprot
F6VAP0
resolver
uniprot
Q8NI52
resolver
uniprot
Q8NI53
resolver
uniprot
Q9NXG3
resolver
uniprot_entry
B7Z8Z7_HUMAN
resolver
uniprot_entry
F6VAP0_HUMAN
resolver
uniprot_entry
RBM47_HUMAN
resolver
uniprot_sec
A0PJK2
resolver
uniprot_sec
B5MED4
resolver
uniprot_sec
Q8NI52
resolver
uniprot_sec
Q8NI53
resolver
uniprot_sec
Q9NXG3
resolver
amino_acid_sequence
MTAEDSTAAMSSDSAAGSSAKVPEGVAGAPNEAALLALMERTGYSMVQENGQRKYGGPPPGWEGPHPQRGCEVFVGKIPRDVYEDELVPVFEAVGRIYELRLMMDFDGKNRGYAFVMYCHKHEAKRAVRELNNYEIRPGRLLGVCCSVDNCRLFIGGIPKMKKREEILEEIAKVTEGVLDVIVYASAADKMKNRGFAFVEYESHRAAAMARRKLMPGRIQLWGHQIAVDWAEPEIDVDEDVMETVKILYVRNLMIETTEDTIKKSFGQFNPGCVERVKKIRDYAFVHFTSREDAVHAMNNLNGTELEGSCLEVTLAKPVDKEQYSRYQKAARGGGAAEAAQQPSYVYSCDPYTLAYYGYPYNALIGPNRDYFVKAGSIRGRGRGAAGNRAPGPRGSYLGGYSAGRGIYSRYHEGKGKQQEKGYELVPNLEIPTVNPVAIKPGTVAIPAIGAQYSMFPAAPAPKMIEDGKIHTVEHMISPIAVQPDPASAAAAAAAAAAAAAAVIPTVSTPPPFQGRPITPVYTVAPNVQRIPTAGIYGASYVPFAAPATATIATLQKNAAAAAAMYGGYAGYIPQAFPAAAIQVPIPDVYQTY
uniprot
proteins
function
FUNCTION: Single-stranded RNA-binding protein that functions in a variety of RNA processes, including alternative splicing, RNA stabilization, and RNA editing (PubMed:24038582, PubMed:24916387, PubMed:27050523, PubMed:30844405, PubMed:31358901, PubMed:34160127). Functions as an enzyme-substrate adapter for the cytidine deaminase APOBEC1. With APOBEC1 forms an mRNA editing complex involved into cytidine to uridine editing of a variety of mRNA molecules (PubMed:24038582, PubMed:24916387, PubMed:30844405). Through the binding of their 3'UTR, also stabilizes a variety of mRNAs and regulates the expression of genes such as the interferon alpha/beta receptor and interleukin-10 (PubMed:34160127). Also involved in the alternative splicing of several genes including TJP1. Binds the pre-mRNA (U)GCAUG consensus sequences in downstream intronic regions of alternative exons, regulating their exclusion and inclusion into mRNAs (PubMed:27050523, PubMed:31358901). Independently of its RNA-binding activity, could negatively regulate MAVS by promoting its lysosomal degradation (By similarity). {ECO:0000250|UniProtKB:A0A8M1NHK4, ECO:0000269|PubMed:24038582, ECO:0000269|PubMed:24916387, ECO:0000269|PubMed:27050523, ECO:0000269|PubMed:30844405, ECO:0000269|PubMed:31358901, ECO:0000269|PubMed:34160127}.
uniprot
proteins
mass_dalton
64099
uniprot
proteins
mutagenesis
MUTAGEN 115; /note="F->A: Loss of function in regulation of alternative splicing. Loss of pre-mRNA binding activity. Decreased homodimerization."; /evidence="ECO:0000269|PubMed:31358901"; MUTAGEN 198; /note="F->A: Decreased function in regulation of alternative splicing. Decreased pre-mRNA binding. No effect on homodimerization."; /evidence="ECO:0000269|PubMed:31358901"; MUTAGEN 285; /note="F->A: Decreased function in regulation of alternative splicing. No effect on pre-mRNA binding."; /evidence="ECO:0000269|PubMed:31358901
uniprot
proteins
protein_family
RRM RBM47 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
24038582
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24916387
uniprot
proteins
pubmed
27050523
uniprot
proteins
pubmed
30844405
uniprot
proteins
pubmed
31358901
uniprot
proteins
pubmed
34160127
uniprot
proteins
pubmed
37548402
uniprot
proteins
sequence_length
593
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24038582, ECO:0000269|PubMed:24916387}. Cytoplasm {ECO:0000269|PubMed:24916387}.
uniprot
proteins