Bhlhe41
entrez
79362
canonical
uniprot
Q99PV5
canonical
ensembl
ENSMUSG00000030256
resolver
ensp
ENSMUSP00000032386
resolver
ensp
ENSMUSP00000107332
resolver
enst
ENSMUST00000032386
resolver
enst
ENSMUST00000111703
resolver
genesymbol
Bhlhe41
resolver
genesymbol_syn
BHLHB3
resolver
genesymbol_syn
Bhlhb3
resolver
genesymbol_syn
Dec2
resolver
uniprot
D3Z2G6
resolver
uniprot
Q6L8F5
resolver
uniprot_entry
BHE41_MOUSE
resolver
uniprot_entry
D3Z2G6_MOUSE
resolver
uniprot_entry
Q6L8F5_MOUSE
resolver
amino_acid_sequence
MDEGIPHLQERQLLEHRDFIGLDYSSLYMCKPKRSLKRDDTKDTYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHLKALTALTEQQHQKIIALQNGERSLKSPVQADLDAFHSGFQTCAKEVLQYLARFESWTPREPRCAQLVSHLHAVATQLLTPQVPSGRGSGRAPCSAGAAAASGPERVARCVPVIQRTQPGTEPEHDTDTDSGYGGEAEQGRAAVKQEPPGDSSPAPKRPKLEARGALLGPEPALLGSLVALGGGAPFAQPAAAPFCLPFYLLSPSAAAYVQPWLDKSGLDKYLYPAAAAPFPLLYPGIPAAAAAAAAAAFPCLSSVLSPPPEKAGATAGAPFLAHEVAPPGPLRPQHAHSRTHLPRAVNPESSQEDATQPAKDAP
uniprot
proteins
function
FUNCTION: Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-BMAL1 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA/B/G, NR1H3/LXRA, NR1H4 and VDR transactivation activity. Inhibits HNF1A-mediated transactivation of CYP1A2, CYP2E1 and CYP3A11 (PubMed:30555544). {ECO:0000269|PubMed:12397359, ECO:0000269|PubMed:14672706, ECO:0000269|PubMed:18411297, ECO:0000269|PubMed:19786558, ECO:0000269|PubMed:24736997, ECO:0000269|PubMed:30555544}.
uniprot
proteins
mass_dalton
43946
uniprot
proteins
pubmed
11162494
uniprot
proteins
pubmed
12397359
uniprot
proteins
pubmed
14672706
uniprot
proteins
pubmed
15560782
uniprot
proteins
pubmed
18411297
uniprot
proteins
pubmed
19679812
uniprot
proteins
pubmed
19786558
uniprot
proteins
pubmed
24736997
uniprot
proteins
pubmed
30555544
uniprot
proteins
sequence_length
410
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981}.
uniprot
proteins