TRIB1
entrez
10221
canonical
uniprot
Q96RU8
canonical
ensembl
ENSG00000173334
resolver
ensp
ENSP00000312150
resolver
ensp
ENSP00000429063
resolver
genesymbol
TRIB1
resolver
genesymbol_syn
C8FW
resolver
genesymbol_syn
GIG2
resolver
genesymbol_syn
TRB1
resolver
hgnc
HGNC:16891
resolver
uniprot
B4DMM6
resolver
uniprot
C5HU08
resolver
uniprot
O15180
resolver
uniprot
Q9H2Y8
resolver
uniprot_entry
TRIB1_HUMAN
resolver
uniprot_sec
B4DMM6
resolver
uniprot_sec
C5HU08
resolver
uniprot_sec
O15180
resolver
uniprot_sec
Q9H2Y8
resolver
amino_acid_sequence
MRVGPVRSAMSGASQPRGPALLFPATRGVPAKRLLDADDAAAVAAKCPRLSECSSPPDYLSPPGSPCSPQPPPAAPGAGGGSGSAPGPSRIADYLLLPLAEREHVSRALCIHTGRELRCKVFPIKHYQDKIRPYIQLPSHSNITGIVEVILGETKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIMKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHISPKARCLIRSLLRREPSERLTAPEILLHPWFESVLEPGYIDSEIGTSDQIVPEYQEDSDISSFFC
uniprot
proteins
function
FUNCTION: Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:27041596). The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797). {ECO:0000250|UniProtKB:Q8K4K4, ECO:0000269|PubMed:15299019, ECO:0000269|PubMed:26455797, ECO:0000305|PubMed:27041596}.
uniprot
proteins
mass_dalton
41009
uniprot
proteins
mutagenesis
MUTAGEN 355; /note="D->A: Decreased interaction with COP1."; /evidence="ECO:0000269|PubMed:27041596"; MUTAGEN 356; /note="Q->A: Decreased interaction with COP1."; /evidence="ECO:0000269|PubMed:27041596"; MUTAGEN 357; /note="I->A: Decreased interaction with COP1."; /evidence="ECO:0000269|PubMed:27041596"; MUTAGEN 358; /note="V->I,A: Loss of interaction with COP1."; /evidence="ECO:0000269|PubMed:27041596"; MUTAGEN 359; /note="P->A: Strongly decreased interaction with COP1."; /evidence="ECO:0000269|PubMed:27041596"; MUTAGEN 360; /note="E->A: Decreased interaction with COP1."; /evidence="ECO:0000269|PubMed:27041596"; MUTAGEN 361; /note="Y->A: No effect on interaction with COP1."; /evidence="ECO:0000269|PubMed:27041596
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tribbles subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15299019
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
20410507
uniprot
proteins
pubmed
26455797
uniprot
proteins
pubmed
27041596
uniprot
proteins
pubmed
9342215
uniprot
proteins
sequence_length
372
uniprot
proteins