SLAMF6
entrez
114836
canonical
uniprot
Q96DU3
canonical
ensembl
ENSG00000162739
resolver
ensp
ENSP00000357034
resolver
ensp
ENSP00000357036
resolver
ensp
ENSP00000357038
resolver
ensp
ENSP00000543261
resolver
genesymbol
SLAMF6
resolver
genesymbol_syn
KALI
resolver
hgnc
HGNC:21392
resolver
uniprot
A6NMW2
resolver
uniprot
B2R8X8
resolver
uniprot
B4E1U5
resolver
uniprot
Q14CF0
resolver
uniprot
Q5TAS4
resolver
uniprot
Q5TAS6
resolver
uniprot
Q5TAT3
resolver
uniprot
Q96DV0
resolver
uniprot_entry
B4E1U5_HUMAN
resolver
uniprot_entry
SLAF6_HUMAN
resolver
uniprot_sec
A6NMW2
resolver
uniprot_sec
B2R8X8
resolver
uniprot_sec
Q14CF0
resolver
uniprot_sec
Q5TAS4
resolver
uniprot_sec
Q5TAS6
resolver
uniprot_sec
Q5TAT3
resolver
uniprot_sec
Q96DV0
resolver
amino_acid_sequence
MLWLFQSLLFVFCFGPGNVVSQSSLTPLMVNGILGESVTLPLEFPAGEKVNFITWLFNETSLAFIVPHETKSPEIHVTNPKQGKRLNFTQSYSLQLSNLKMEDTGSYRAQISTKTSAKLSSYTLRILRQLRNIQVTNHSQLFQNMTCELHLTCSVEDADDNVSFRWEALGNTLSSQPNLTVSWDPRISSEQDYTCIAENAVSNLSFSVSAQKLCEDVKIQYTDTKMILFMVSGICIVFGFIILLLLVLRKRRDSLSLSTQRTQGPAESARNLEYVSVSPTNNTVYASVTHSNRETEIWTPRENDTITIYSTINHSKESKPTFSRATALDNVV
uniprot
proteins
function
FUNCTION: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors (PubMed:11489943, PubMed:16920955). Positive signaling in NK cells implicates phosphorylation of VAV1. NK cell activation seems to depend on SH2D1B and not on SH2D1A (PubMed:16920955). In conjunction with SLAMF1 controls the transition between positive selection and the subsequent expansion and differentiation of the thymocytic natural killer T (NKT) cell lineage (By similarity). Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion; the costimulatory activity requires SH2D1A (PubMed:16920955, PubMed:22184727). Promotes recruitment of RORC to the IL-17 promoter (PubMed:22989874). In conjunction with SLAMF1 and CD84/SLAMF5 may be a negative regulator of the humoral immune response. In the absence of SH2D1A/SAP can transmit negative signals to CD4(+) T-cells and NKT cells. Negatively regulates germinal center formation by inhibiting T-cell:B-cell adhesion; the function probably implicates increased association with PTPN6/SHP-1 via ITSMs in absence of SH2D1A/SAP. However, reported to be involved in maintaining B-cell tolerance in germinal centers and in preventing autoimmunity (By similarity). {ECO:0000250|UniProtKB:Q9ET39, ECO:0000269|PubMed:11489943, ECO:0000269|PubMed:16920955, ECO:0000269|PubMed:22184727, ECO:0000269|PubMed:22989874}.
uniprot
proteins
mass_dalton
37345
uniprot
proteins
mutagenesis
MUTAGEN 108; /note="R->A: Inhibits dimerization."; /evidence="ECO:0000269|PubMed:17045824"; MUTAGEN 110; /note="Q->A: Inhibits dimerization."; /evidence="ECO:0000269|PubMed:17045824"; MUTAGEN 112; /note="S->A: Inhibits dimerization."; /evidence="ECO:0000269|PubMed:17045824"; MUTAGEN 274; /note="Y->F: Retains reduced SLAMF6-mediated cytotoxicity, disrupts interaction with SH2D1A and retains interaction with SH2D1B; when associated with F-309."; /evidence="ECO:0000269|PubMed:16920955"; MUTAGEN 285; /note="Y->F: Abolishes SLAMF6-mediated cytotoxicity, disrupts interaction with SH2D1B and retains interaction with SH2D1A."; /evidence="ECO:0000269|PubMed:16920955"; MUTAGEN 309; /note="Y->F: Reduced SLAMF6-mediated cytotoxicity."; /evidence="ECO:0000269|PubMed:16920955"; MUTAGEN 309; /note="Y->F: Retains reduced SLAMF6-mediated cytotoxicity, disrupts interaction with SH2D1A and retains interaction with SH2D1B; when associated with F-273."; /evidence="ECO:0000269|PubMed:16920955
uniprot
proteins
post_translational_modification
PTM: Phosphorylation in NK cells upon engagment by SLAMF6-expressing target cells is leading to receptor activation. {ECO:0000269|PubMed:16920955}.
uniprot
proteins
pubmed
11489943
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16920955
uniprot
proteins
pubmed
17045824
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
22184727
uniprot
proteins
pubmed
22989874
uniprot
proteins
sequence_length
332
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 227..247; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins