CD300A
entrez
11314
canonical
uniprot
Q9UGN4
canonical
ensembl
ENSG00000167851
resolver
ensembl
ENSG00000291918
resolver
ensp
ENSP00000308188
resolver
ensp
ENSP00000353259
resolver
ensp
ENSP00000376401
resolver
ensp
ENSP00000463189
resolver
ensp
ENSP00000497133
resolver
ensp
ENSP00000517550
resolver
ensp
ENSP00000517555
resolver
ensp
ENSP00000525687
resolver
ensp
ENSP00000762404
resolver
enst
ENST00000577511
resolver
enst
ENST00000648095
resolver
enst
ENST00000709201
resolver
enst
ENST00000709207
resolver
genesymbol
CD300A
resolver
genesymbol_syn
CMRF35H
resolver
genesymbol_syn
IGSF12
resolver
hgnc
HGNC:19319
resolver
uniprot
A8MW96
resolver
uniprot
J3QKQ4
resolver
uniprot
O95100
resolver
uniprot
Q9HD97
resolver
uniprot
Q9P0F3
resolver
uniprot
Q9UBK4
resolver
uniprot
Q9UMS9
resolver
uniprot
Q9UMT0
resolver
uniprot_entry
CLM8_HUMAN
resolver
uniprot_entry
J3QKQ4_HUMAN
resolver
uniprot_sec
A8MW96
resolver
uniprot_sec
O95100
resolver
uniprot_sec
Q9HD97
resolver
uniprot_sec
Q9P0F3
resolver
uniprot_sec
Q9UBK4
resolver
uniprot_sec
Q9UMS9
resolver
uniprot_sec
Q9UMT0
resolver
amino_acid_sequence
MWLPWALLLLWVPGCFALSKCRTVAGPVGGSLSVQCPYEKEHRTLNKYWCRPPQIFLCDKIVETKGSAGKRNGRVSIRDSPANLSFTVTLENLTEEDAGTYWCGVDTPWLRDFHDPVVEVEVSVFPASTSMTPASITAAKTSTITTAFPPVSSTTLFAVGATHSASIQEETEEVVNSQLPLLLSLLALLLLLLVGASLLAWRMFQKWIKAGDHSELSQNPKQAATQSELHYANLELLMWPLQEKPAPPREVEVEYSTVASPREELHYASVVFDSNTNRIAAQRPREEEPDSDYSVIRKT
uniprot
proteins
function
FUNCTION: Inhibitory receptor which may contribute to the down-regulation of cytolytic activity in natural killer (NK) cells, and to the down-regulation of mast cell degranulation (PubMed:10746781, PubMed:16339535, PubMed:9701027). Negatively regulates the Toll-like receptor (TLR) signaling mediated by MYD88 but not TRIF through activation of PTPN6 (PubMed:22043923). {ECO:0000269|PubMed:10746781, ECO:0000269|PubMed:16339535, ECO:0000269|PubMed:22043923, ECO:0000269|PubMed:9701027}.
uniprot
proteins
mass_dalton
33201
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine. {ECO:0000269|PubMed:10540326, ECO:0000269|PubMed:16339535}.; PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q6SJQ0}.
uniprot
proteins
protein_family
CD300 family
uniprot
proteins
pubmed
10540326
uniprot
proteins
pubmed
10746781
uniprot
proteins
pubmed
12483297
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16339535
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
22043923
uniprot
proteins
pubmed
9701027
uniprot
proteins
sequence_length
299
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 181..201; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins