Cxxc5
entrez
291670
canonical
uniprot
Q5XIQ3
canonical
ensembl
ENSRNOG00000032878
resolver
ensembl
ENSRNOG00055023891
resolver
ensembl
ENSRNOG00060019994
resolver
ensembl
ENSRNOG00065012385
resolver
ensp
ENSRNOP00000042976
resolver
ensp
ENSRNOP00000094752
resolver
ensp
ENSRNOP00055033331
resolver
ensp
ENSRNOP00060028405
resolver
ensp
ENSRNOP00065015484
resolver
enst
ENSRNOT00000045795
resolver
enst
ENSRNOT00000104184
resolver
enst
ENSRNOT00055041001
resolver
enst
ENSRNOT00060034591
resolver
enst
ENSRNOT00065020173
resolver
genesymbol
Cxxc5
resolver
uniprot
A0A8I6AID9
resolver
uniprot_entry
A0A8I6AID9_RAT
resolver
uniprot_entry
CXXC5_RAT
resolver
amino_acid_sequence
MSSLGGGSQDAGGSSSSSNTSSSSGSGQKAGGTDKSATVAATAPASVADDAPPPERRNKSGIISEPLNKSLRRSRPLSHYSSFGSSGGAGSMMGGESADKAAAAAASLLANGHDLAAAMAVDKSNPTSKHKSGAVASLLSKAERATELAAEGQLTLQQFAQSTEMLKRVVQEHLPLMSEAGAGLPDMEAVAGAEALNGQSDFPYLGAFPINPGLFIMTPAGVFLAESALHMAGLAEYPMQGELASAISSGKKKRKRCGMCAPCRRRINCEQCSSCRNRKTGHQICKFRKCEELKKKPSAALEKVMLPSGAAFRWFQ
uniprot
proteins
function
FUNCTION: May indirectly participate in activation of the NF-kappa-B and MAPK pathways (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis (By similarity). Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (PubMed:19001364). Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (By similarity). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (By similarity). {ECO:0000250|UniProtKB:Q7LFL8, ECO:0000269|PubMed:19001364}.
uniprot
proteins
mass_dalton
32626
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19001364
uniprot
proteins
sequence_length
316
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19001364}. Cytoplasm {ECO:0000269|PubMed:19001364}. Note=Colocalizes with DVL1 in large bodies localized just outside the nuclear membrane.
uniprot
proteins