Clcn7
entrez
29233
canonical
uniprot
P51799
canonical
ensembl
ENSRNOG00000016976
resolver
ensp
ENSRNOP00000079343
resolver
ensp
ENSRNOP00000093984
resolver
enst
ENSRNOT00000113001
resolver
enst
ENSRNOT00000120159
resolver
genesymbol
Clcn7
resolver
uniprot
A0A8I5ZMW4
resolver
uniprot_entry
A0A8I5ZMW4_RAT
resolver
uniprot_entry
CLCN7_RAT
resolver
amino_acid_sequence
MANVSKKVSWSGRDRDDEEGAPLLRRTGQPDEETPLLNGAGPGARQSHSALFRIGQMNNVELDDELLDPEVDPPHTFPKEIPHNEKLLSLKYESLDYDNSENQLFLEEERRINHTAFRTVEIKRWVICALIGILTGLVACFIDIVVENLAGLKYRVIKDNIDKFTEKGGLSFSLLLWATLNSAFVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGGLAVGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGAPVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRFDSEKMAYTIHEIPVFIAMGVVGGILGAVFNALNYWLTMFRIRYIHRPCLQVIEAMLVAAVTATVAFVLIYSSRDCQPLQGSSMSYPLQLFCADGEYNSMAAAFFNTPEKSVVSLFHDPPGSYNPMTLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFGISMSYLTGAAIWADPGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFPIMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLHWEAPVTSHSLTAREVMSTPVTCLRRREKVGIIVDVLSDTASNHNGFPVVEDVGDTQPARLQGLILRSQLIVLLKHKVFVERSNMGLVQRRLRLKDFRDAYPRFPPIQSIHVSQDERECTMDLSEFMNPSPYTVPQEASLPRVFKLFRALGLRHLVVVDNHNQVVGLVTRKDLARYRLGKGGLEELSLAQT
uniprot
proteins
function
FUNCTION: Slowly voltage-gated channel mediating the exchange of chloride ions against protons (PubMed:18449189). Functions as antiporter and contributes to the acidification of the lysosome lumen and may be involved in maintaining lysosomal pH (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (PubMed:18449189). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). {ECO:0000250|UniProtKB:O70496, ECO:0000250|UniProtKB:P35523, ECO:0000269|PubMed:18449189}.
uniprot
proteins
mass_dalton
88731
uniprot
proteins
protein_family
Chloride channel (TC 2.A.49) family
uniprot
proteins
protein_family
ClC-7/CLCN7 subfamily
uniprot
proteins
pubmed
16222710
uniprot
proteins
pubmed
18449189
uniprot
proteins
pubmed
8543009
uniprot
proteins
sequence_length
803
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:16222710, ECO:0000269|PubMed:18449189}; Multi-pass membrane protein {ECO:0000269|PubMed:16222710, ECO:0000269|PubMed:18449189}.
uniprot
proteins
transmembrane_region
TRANSMEM 125..157; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 172..195; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 221..239; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 245..262; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 320..339; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 373..403; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 408..430; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 485..505; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 510..533; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 577..595; /note="Helical"; /evidence="ECO:0000250
uniprot
proteins