NAP1L2
entrez
4674
canonical
uniprot
Q9ULW6
canonical
ensembl
ENSG00000186462
resolver
ensp
ENSP00000362616
resolver
genesymbol
NAP1L2
resolver
genesymbol_syn
BPX
resolver
hgnc
HGNC:7638
resolver
uniprot
B2RE61
resolver
uniprot
B4E161
resolver
uniprot
Q8TAN6
resolver
uniprot_entry
NP1L2_HUMAN
resolver
uniprot_sec
B2RE61
resolver
uniprot_sec
B4E161
resolver
uniprot_sec
Q8TAN6
resolver
amino_acid_sequence
MAESENRKELSESSQEEAGNQIMVEGLGEHLERGEDAAAGLGDDGKCGEEAAAGLGEEGENGEDTAAGSGEDGKKGGDTDEDSEADRPKGLIGYVLDTDFVESLPVKVKYRVLALKKLQTRAANLESKFLREFHDIERKFAEMYQPLLEKRRQIINAIYEPTEEECEYKSDSEDCDDEEMCHEEMYGNEEGMVHEYVDEDDGYEDYYYDYAVEEEEEEEEEDDIEATGEENKEEEDPKGIPDFWLTVLKNVDTLTPLIKKYDEPILKLLTDIKVKLSDPGEPLSFTLEFHFKPNEYFKNELLTKTYVLKSKLAYYDPHPYRGTAIEYSTGCEIDWNEGKNVTLKTIKKKQKHRIWGTIRTVTEDFPKDSFFNFFSPHGITSNGRDGNDDFLLGHNLRTYIIPRSVLFFSGDALESQQEGVVREVNDAIYDKIIYDNWMAAIEEVKACCKNLEALVEDIDR
uniprot
proteins
function
FUNCTION: Histone chaperone (By similarity). Plays a role in the epigenetic regulation of gene expression during cellular differentiation, by regulating the acetylation status of histone H3 and therefore chromatin accessibility (PubMed:35032339). Plays a role in the differentiation of neuronal cells (By similarity). Increased activity during aging may suppress osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and promote their senescence; recruits SIRT1 to deacetylate histone H3 'Lys-14' at the promoter of osteogenic genes (PubMed:35032339). {ECO:0000250|UniProtKB:P51860, ECO:0000250|UniProtKB:P55209, ECO:0000269|PubMed:35032339}.
uniprot
proteins
mass_dalton
52542
uniprot
proteins
protein_family
Nucleosome assembly protein (NAP) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
35032339
uniprot
proteins
sequence_length
460
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:35032339}. Chromosome {ECO:0000305|PubMed:35032339}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P51860}. Note=Localizes to chromatin in the neuronal nucleus (By similarity). Cytoplasmic in the G1 phase, nuclear during S-phase (By similarity). {ECO:0000250|UniProtKB:P51860}.
uniprot
proteins