Gfra1
entrez
14585
canonical
uniprot
P97785
canonical
ensembl
ENSMUSG00000025089
resolver
ensp
ENSMUSP00000026076
resolver
ensp
ENSMUSP00000117196
resolver
ensp
ENSMUSP00000130128
resolver
genesymbol
Gfra1
resolver
genesymbol_syn
Gdnfra
resolver
genesymbol_syn
Trnr1
resolver
uniprot
O35246
resolver
uniprot
O35252
resolver
uniprot_entry
GFRA1_MOUSE
resolver
uniprot_sec
O35246
resolver
uniprot_sec
O35252
resolver
amino_acid_sequence
MFLATLYFVLPLLDLLMSAEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGKETNFSLTSGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSLQGNDLLEDSPYEPVNSRLSDIFRAVPFISDVFQQVEHISKGNNCLDAAKACNLDDTCKKYRSAYITPCTTSMSNEVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDVACTERRRQTIVPVCSYEERERPNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSNCLKENYADCLLAYSGLIGTVMTPNYIDSSSLSVAPWCDCSNSGNDLEDCLKFLNFFKDNTCLKNAIQAFGNGSDVTMWQPAPPVQTTTATTTTAFRIKNKPLGPAGSENEIPTHVLPPCANLQAQKLKSNVSGSTHLCLSDNDYGKDGLAGASSHITTKSMAAPPSCGLSSLPVMVFTALAALLSVSLAETS
uniprot
proteins
function
FUNCTION: Coreceptor for GDNF, a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. GDNF-binding leads to autophosphorylation and activation of the RET receptor. {ECO:0000250|UniProtKB:P56159}.
uniprot
proteins
mass_dalton
51752
uniprot
proteins
protein_family
GDNFR family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23333276
uniprot
proteins
pubmed
9592044
uniprot
proteins
sequence_length
468
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q62997}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q62997}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q62997}. Endosome {ECO:0000250|UniProtKB:Q62997}. Endosome, multivesicular body {ECO:0000250|UniProtKB:Q62997}. Note=Localizes mainly to the plasma membrane. In the presence of SORL1, shifts to vesicular structures, including trans-Golgi network, endosomes and multivesicular bodies. {ECO:0000250|UniProtKB:Q62997}.
uniprot
proteins