SLCO1A2
entrez
6579
canonical
uniprot
P46721
canonical
ensembl
ENSG00000084453
resolver
ensp
ENSP00000305974
resolver
ensp
ENSP00000394854
resolver
ensp
ENSP00000508235
resolver
ensp
ENSP00000608316
resolver
ensp
ENSP00000608317
resolver
ensp
ENSP00000608319
resolver
enst
ENST00000458504
resolver
genesymbol
SLCO1A2
resolver
genesymbol_syn
OATP
resolver
genesymbol_syn
OATP1
resolver
genesymbol_syn
OATP1A2
resolver
genesymbol_syn
SLC21A3
resolver
hgnc
HGNC:10956
resolver
uniprot
B4DJE6
resolver
uniprot
F6SH69
resolver
uniprot
Q9UGP7
resolver
uniprot
Q9UL38
resolver
uniprot_entry
B4DJE6_HUMAN
resolver
uniprot_entry
F6SH69_HUMAN
resolver
uniprot_entry
SO1A2_HUMAN
resolver
uniprot_sec
Q9UGP7
resolver
uniprot_sec
Q9UL38
resolver
activity_regulation
ACTIVITY REGULATION: Transport activity is inhibited by the grapefruit juice component naringin. {ECO:0000269|PubMed:17301733}.
uniprot
proteins
amino_acid_sequence
MGETEKRIETHRIRCLSKLKMFLLAITCAFVSKTLSGSYMNSMLTQIERQFNIPTSLVGFINGSFEIGNLLLIIFVSYFGTKLHRPIMIGIGCVVMGLGCFLKSLPHFLMNQYEYESTVSVSGNLSSNSFLCMENGTQILRPTQDPSECTKEVKSLMWVYVLVGNIVRGMGETPILPLGISYIEDFAKFENSPLYIGLVETGAIIGPLIGLLLASFCANVYVDTGFVNTDDLIITPTDTRWVGAWWFGFLICAGVNVLTAIPFFFLPNTLPKEGLETNADIIKNENEDKQKEEVKKEKYGITKDFLPFMKSLSCNPIYMLFILVSVIQFNAFVNMISFMPKYLEQQYGISSSDAIFLMGIYNLPPICIGYIIGGLIMKKFKITVKQAAHIGCWLSLLEYLLYFLSFLMTCENSSVVGINTSYEGIPQDLYVENDIFADCNVDCNCPSKIWDPVCGNNGLSYLSACLAGCETSIGTGINMVFQNCSCIQTSGNSSAVLGLCDKGPDCSLMLQYFLILSAMSSFIYSLAAIPGYMVLLRCMKSEEKSLGVGLHTFCTRVFAGIPAPIYFGALMDSTCLHWGTLKCGESGACRIYDSTTFRYIYLGLPAALRGSSFVPALIILILLRKCHLPGENASSGTELIETKVKGKENECKDIYQKSTVLKDDELKTKL
uniprot
proteins
function
FUNCTION: Na(+)-independent transporter that mediates the cellular uptake of a broad range of organic anions such as the endogenous bile salts cholate and deoxycholate, either in their unconjugated or conjugated forms (taurocholate and glycocholate), at the plasmam membrane (PubMed:19129463, PubMed:7557095). Responsible for intestinal absorption of bile acids (By similarity). Transports dehydroepiandrosterone 3-sulfate (DHEAS), a major circulating steroid secreted by the adrenal cortex, as well as estrone 3-sulfate and 17beta-estradiol 17-O-(beta-D-glucuronate) (PubMed:11159893, PubMed:12568656, PubMed:19129463, PubMed:23918469, PubMed:25560245, PubMed:9539145). Mediates apical uptake of all-trans-retinol (atROL) across human retinal pigment epithelium, which is essential to maintaining the integrity of the visual cycle and thus vision (PubMed:25560245). Involved in the uptake of clinically used drugs (PubMed:17301733, PubMed:20686826, PubMed:27777271). Capable of thyroid hormone transport (both T3 or 3,3',5'-triiodo-L-thyronine, and T4 or L-tyroxine) (PubMed:19129463, PubMed:20358049). Also transports prostaglandin E2 (PubMed:19129463). Plays roles in blood-brain and -cerebrospinal fluid barrier transport of organic anions and signal mediators, and in hormone uptake by neural cells (By similarity). May also play a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons (PubMed:25132355). May play an important role in plasma and tissue distribution of the structurally diverse chemotherapeutic drugs methotrexate and paclitaxel (PubMed:23243220). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:19129463). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (PubMed:19129463). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable). {ECO:0000250|UniProtKB:O88397, ECO:0000250|UniProtKB:Q91YY5, ECO:0000269|PubMed:11159893, ECO:0000269|PubMed:12568656, ECO:0000269|PubMed:17301733, ECO:0000269|PubMed:19129463, ECO:0000269|PubMed:20358049, ECO:0000269|PubMed:20686826, ECO:0000269|PubMed:23243220, ECO:0000269|PubMed:23918469, ECO:0000269|PubMed:25132355, ECO:0000269|PubMed:25560245, ECO:0000269|PubMed:27777271, ECO:0000269|PubMed:7557095, ECO:0000269|PubMed:9539145, ECO:0000305|PubMed:35307651}.
uniprot
proteins
mass_dalton
74145
uniprot
proteins
protein_family
Organo anion transporter (TC 2.A.60) family
uniprot
proteins
pubmed
10779507
uniprot
proteins
pubmed
10873595
uniprot
proteins
pubmed
11159893
uniprot
proteins
pubmed
11238933
uniprot
proteins
pubmed
12409283
uniprot
proteins
pubmed
12568656
uniprot
proteins
pubmed
15632119
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17301733
uniprot
proteins
pubmed
19129463
uniprot
proteins
pubmed
20358049
uniprot
proteins
pubmed
20686826
uniprot
proteins
pubmed
23243220
uniprot
proteins
pubmed
23918469
uniprot
proteins
pubmed
25132355
uniprot
proteins
pubmed
25560245
uniprot
proteins
pubmed
27777271
uniprot
proteins
pubmed
35307651
uniprot
proteins
pubmed
7557095
uniprot
proteins
pubmed
9539145
uniprot
proteins
sequence_length
670
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15632119, ECO:0000269|PubMed:25132355}; Multi-pass membrane protein {ECO:0000305}. Basal cell membrane {ECO:0000269|PubMed:35307651}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the basal membrane of Sertoli cells. {ECO:0000269|PubMed:35307651}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..40; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 60..80; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 87..111; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 156..184; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 204..224; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 243..267; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 312..333; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 354..377; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 382..405; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 514..536; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 546..571; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 606..623; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins