H2ab1
entrez
68231
canonical
uniprot
Q9CQ70
canonical
ensembl
ENSMUSG00000062651
resolver
ensp
ENSMUSP00000100618
resolver
enst
ENSMUST00000105001
resolver
genesymbol
H2ab1
resolver
genesymbol_syn
H2afb1
resolver
genesymbol_syn
H2al2a
resolver
uniprot
Q9D9Q5
resolver
uniprot_entry
H2AB1_MOUSE
resolver
uniprot_sec
Q9D9Q5
resolver
amino_acid_sequence
MARKRQRRRRRKVTRSQRAELQFPVSRVDRFLREGNYSRRLSSSAPVFLAGVLEYLTSNILELAGEVAHTTGRKRIAPEHVCRVVQNNEQLHQLFKQGGTSVFEPPEPDDN
uniprot
proteins
function
FUNCTION: Atypical histone H2A which replaces conventional H2A during late spermatogenesis and is involved in the replacement of histones to protamine in male germ cells (PubMed:28366643). Core component of nucleosome: nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (PubMed:19506029). Nucleosomes containing H2AB1 only wrap 130 bp of DNA, compared to 147 bp for classical nucleosomes (PubMed:19506029). In condensing spermatids, the heterodimer between H2AB1 and H2BC1/TH2B is loaded onto the nucleosomes and promotes loading of transition proteins (TNP1 and TNP2) onto the nucleosomes (PubMed:28366643). Inclusion of the H2AB1-H2BC1/TH2B dimer into chromatin opens the nucleosomes, releasing the nucleosomal DNA ends and allowing the invasion of nucleosomes by transition proteins (TNP1 and TNP2) (PubMed:28366643). Then, transition proteins drive the recruitment and processing of protamines, which are responsible for histone eviction (PubMed:28366643). {ECO:0000269|PubMed:19506029, ECO:0000269|PubMed:28366643}.
uniprot
proteins
mass_dalton
12843
uniprot
proteins
protein_family
Histone H2A family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17261847
uniprot
proteins
pubmed
18703863
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19506029
uniprot
proteins
pubmed
20008104
uniprot
proteins
pubmed
20188161
uniprot
proteins
pubmed
28366643
uniprot
proteins
sequence_length
111
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17261847}. Chromosome {ECO:0000269|PubMed:17261847}. Note=Specifically localizes to the pericentric regions in condensing spermatids (PubMed:17261847). {ECO:0000269|PubMed:17261847}.
uniprot
proteins