MOV10L1
entrez
54456
canonical
uniprot
Q9BXT6
canonical
ensembl
ENSG00000073146
resolver
ensp
ENSP00000262794
resolver
ensp
ENSP00000379193
resolver
ensp
ENSP00000379199
resolver
ensp
ENSP00000438542
resolver
genesymbol
MOV10L1
resolver
hgnc
HGNC:7201
resolver
uniprot
A7E211
resolver
uniprot
A8MXC6
resolver
uniprot
B7WPP1
resolver
uniprot
B7Z7R1
resolver
uniprot
F5H403
resolver
uniprot
Q5TGD5
resolver
uniprot
Q8NBD4
resolver
uniprot
Q9NXW3
resolver
uniprot
Q9UFB3
resolver
uniprot
Q9UGX9
resolver
uniprot_entry
M10L1_HUMAN
resolver
uniprot_sec
A7E211
resolver
uniprot_sec
A8MXC6
resolver
uniprot_sec
B7WPP1
resolver
uniprot_sec
B7Z7R1
resolver
uniprot_sec
F5H403
resolver
uniprot_sec
Q5TGD5
resolver
uniprot_sec
Q8NBD4
resolver
uniprot_sec
Q9NXW3
resolver
uniprot_sec
Q9UFB3
resolver
uniprot_sec
Q9UGX9
resolver
amino_acid_sequence
MLSLAAKLVAFFWRTADTPREEAGQLEPELAEGDTKLKTVRGVVTRYCSDYGMIDDMIYFSSDAVTSRVLLNVGQEVIAVVEENKVSNGLKAIRVEAVSDKWEDDSRNHGSPSDCGPRVLIGCVTSLVEGAGCISQTTYFSLESVCEGFEPCKGDWVEAEYRIRPGTWSSEATSVKPLRYKRVDKVCISSLCGRNGVLEESIFFTLDSLKLPDGYTPRRGDVVNAVVVESSQSCYVWRALCMTLVKRRDAAPVHEATHFYGTILLKNKGDIEVTQVTHFGTLKEGRSKTMVIWIENKGDIPQNLVSCKLAGWDKSKQFRFQMLDKDQMCPVVSFVSVPEKENSSDENINSLNSHTKNKTSQMSESSLVNNRGISPGDCTCKGENGEKDNILSRKQMTEPEPGGLVPPGGKTFIVVICDGKNPGRCKELLLLCFSDFLIGRYLEVNVISGEESLIAAREPFSWKKLKSSQALTSAKTTVVVTAQKRNSRRQLPSFLPQYPIPDRLRKCVEQKIDILTFQPLLAELLNMSNYKEKFSTLLWLEEIYAEMELKEYNMSGIILRRNGDLLVLEVPGLAEGRPSLYAGDKLILKTQEYNGHAIEYISYVTEIHEEDVTLKINPEFEQAYNFEPMDVEFTYNRTTSRRCHFALEHVIHLGVKVLFPEEIILQSPQVTGNWNHAQDTKSSGQSTSKKNRKTMTDQAEHGTEERRVGDKDLPVLAPFTAEMSDWVDEIQTPKARKMEFFNPVLNENQKLAVKRILSGDCRPLPYILFGPPGTGKTVTIIEAVLQVHFALPDSRILVCAPSNSAADLVCLRLHESKVLQPATMVRVNATCRFEEIVIDAVKPYCRDGEDIWKASRFRIIITTCSSSGLFYQIGVRVGHFTHVFVDEAGQASEPECLIPLGLMSDISGQIVLAGDPMQLGPVIKSRLAMAYGLNVSFLERLMSRPAYQRDENAFGACGAHNPLLVTKLVKNYRSHEALLMLPSRLFYHRELEVCADPTVVTSLLGWEKLPKKGFPLIFHGVRGSEAREGKSPSWFNPAEAVQVLRYCCLLAHSISSQVSASDIGVITPYRKQVEKIRILLRNVDLMDIKVGSVEEFQGQEYLVIIISTVRSNEDRFEDDRYFLGFLSNSKRFNVAITRPKALLIVLGNPHVLVRDPCFGALLEYSITNGVYMGCDLPPALQSLQNCGEGVADPSYPVVPESTGPEKHQEPS
uniprot
proteins
disease_involvement
DISEASE: Spermatogenic failure 73 (SPGF73) [MIM:619878]: An autosomal recessive male infertility disorder characterized by non-obstructive azoospermia due to meiotic arrest. {ECO:0000269|PubMed:35476666}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
5.6.2.5
uniprot
proteins
function
FUNCTION: ATP-dependent 5'-3' RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the primary piRNA metabolic process. Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins. Acts via its ATP-dependent RNA helicase activity: displays 5'-3' RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins. {ECO:0000250|UniProtKB:Q99MV5}.
uniprot
proteins
mass_dalton
135293
uniprot
proteins
protein_family
DNA2/NAM7 helicase family
uniprot
proteins
protein_family
SDE3 subfamily
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
11279525
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
35476666
uniprot
proteins
sequence_length
1211
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99MV5}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250|UniProtKB:Q99MV5}.
uniprot
proteins