Ccdc51
entrez
316008
canonical
uniprot
Q5PPN7
canonical
ensembl
ENSRNOG00000020688
resolver
ensp
ENSRNOP00000070269
resolver
ensp
ENSRNOP00000090082
resolver
ensp
ENSRNOP00000094126
resolver
enst
ENSRNOT00000077228
resolver
enst
ENSRNOT00000102638
resolver
genesymbol
Ccdc51
resolver
genesymbol_syn
Mitok
resolver
uniprot
A0A0G2JXH2
resolver
uniprot
A0A8I6GKL1
resolver
uniprot_entry
A0A0G2JXH2_RAT
resolver
uniprot_entry
A0A8I6GKL1_RAT
resolver
uniprot_entry
MITOK_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Channel activity inhibited by ATP via ABCB8/MITOSUR subunit. {ECO:0000250|UniProtKB:Q96ER9}.
uniprot
proteins
amino_acid_sequence
MTGCSPVFTMQQVVGVSHRLVWRTFRGTDLLMTRTLCSPGPSRPGEKRPEAAALGLYHRLPELGRTLSHTIRNQAASTAKAWWDRYEEFVGLNEVREAQGNVTEAEKVFMVARGLVREAREDLEAQQTKLKEVRDRLDRVSREDNQYLELATLEHRMLQEEKRLRIAYLRAEDSEREKFSLFSAAVRESHEKERTRAERTKNWSLIGSVLGALIGVAGSTYVNRVRLQELKALLLEAQKGPVSLQEAIREQASSYSLQQKDLQNLMVDLRGLVHVGQDQGSGSPTGPSSPRGKDIDGLSAAMKEQLNHSRQVYSCLEGLREQLDSLEKTCSQMAGVVRLAKVPAHPGMVEPLDGALPSSLLEHGSTMLALSEMEQRLEAQANRNAISSTLVTCVTFMATLPLLYMLFKTS
uniprot
proteins
function
FUNCTION: Pore-forming subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)). Together with ATP-binding subunit ABCB8/MITOSUR of the mitoK(ATP) channel, mediates ATP-dependent K(+) currents across the mitochondrial inner membrane. An increase in ATP intracellular levels closes the channel, inhibiting K(+) transport, whereas a decrease in ATP levels enhances K(+) uptake in the mitochondrial matrix. May contribute to the homeostatic control of cellular metabolism under stress conditions by regulating the mitochondrial matrix volume. {ECO:0000250|UniProtKB:Q3URS9}.
uniprot
proteins
mass_dalton
45813
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
410
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q3URS9}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 202..222; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 386..406; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins