Cd82
entrez
12521
canonical
uniprot
P40237
canonical
ensembl
ENSMUSG00000027215
resolver
ensp
ENSMUSP00000028644
resolver
ensp
ENSMUSP00000097287
resolver
ensp
ENSMUSP00000106888
resolver
ensp
ENSMUSP00000112158
resolver
enst
ENSMUST00000028644
resolver
enst
ENSMUST00000099696
resolver
enst
ENSMUST00000111257
resolver
enst
ENSMUST00000116457
resolver
genesymbol
Cd82
resolver
genesymbol_syn
Kai1
resolver
uniprot
Q3UII2
resolver
uniprot_entry
CD82_MOUSE
resolver
uniprot_entry
Q3UII2_MOUSE
resolver
amino_acid_sequence
MGAGCVKVTKYFLFLFNLLFFILGAVILGFGVWILADKNSFISVLQTSSSSLQVGAYVFIGVGAITIVMGFLGCIGAVNEVRCLLGLYFVFLLLILIAQVTVGVLFYFNADKLKKEMGNTVMDIIRNYTANATSSREEAWDYVQAQVKCCGWVSHYNWTENEELMGFTKTTYPCSCEKIKEEDNQLIVKKGFCEADNSTVSENNPEDWPVNTEGCMEKAQAWLQENFGILLGVCAGVAVIELLGLFLSICLCRYIHSEDYSKVPKY
uniprot
proteins
function
FUNCTION: Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Acts as a attenuator of EGF signaling, facilitating ligand-induced endocytosis of the receptor and its subsequent desensitization. Mechanistically, modulates ligand-induced ubiquitination and trafficking of EGFR via E3 ligase CBL phosphorylation by PKC. Increases cell-matrix adhesion by regulating the membrane organization of integrin alpha4/ITA4. Modulates adhesion and suppresses cell migration through other integrins such as the alpha6/ITGA6 and beta1/ITGB1. Decreases cell-associated plasminogen activation by interfering with the interaction between urokinase-type plasminogen activator/PLAU and its receptor PLAUR (By similarity). Associates with CD4 or CD8 and delivers costimulatory signals for the TCR/CD3 pathway. Plays a role in the restrains phagocyte migration but supports macrophage activation (By similarity). Plays a role in TLR9 trafficking to acidified CpG-containing compartments by controlling interaction between TLR9 and VAMP3 and subsequent myddosome assembly (PubMed:31408613). Inhibits LPS-induced inflammatory response by preventing binding of LPS to TLR4 on the cell surface (By similarity). Plays a role in the activation of macrophages into anti-inflammatory phenotypes (PubMed:35754722). Independently of Toll-like receptor (TLR) signaling, is recruited to pathogen-containing phagosomes prior to fusion with lysosomes and participates in antigen presentation (PubMed:21149584). Also acts to control angiogenesis and switch angiogenic milieu to quiescent state by binding and sequestering VEGFA and PDGFA to inhibit the signaling they trigger via their respective cell surface receptor (PubMed:34530889). {ECO:0000250|UniProtKB:P27701, ECO:0000269|PubMed:21149584, ECO:0000269|PubMed:31408613, ECO:0000269|PubMed:34530889, ECO:0000269|PubMed:35754722}.
uniprot
proteins
mass_dalton
29629
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. Palmitoylation contributes to oligomerization and surface expression. {ECO:0000250|UniProtKB:P27701}.
uniprot
proteins
protein_family
Tetraspanin (TM4SF) family
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
21149584
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26562164
uniprot
proteins
pubmed
31408613
uniprot
proteins
pubmed
34530889
uniprot
proteins
pubmed
35754722
uniprot
proteins
pubmed
8039242
uniprot
proteins
sequence_length
266
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:34530889}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21149584}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 54..72; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 84..110; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 228..249; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins