KRT8
entrez
3856
canonical
uniprot
P05787
canonical
ensembl
ENSG00000170421
resolver
ensp
ENSP00000447402
resolver
ensp
ENSP00000449404
resolver
ensp
ENSP00000509398
resolver
genesymbol
KRT8
resolver
genesymbol_syn
CYK8
resolver
hgnc
HGNC:6446
resolver
uniprot
A8K4H3
resolver
uniprot
B0AZN5
resolver
uniprot
F8VXB4
resolver
uniprot
Q14099
resolver
uniprot
Q14716
resolver
uniprot
Q14717
resolver
uniprot
Q53GJ0
resolver
uniprot
Q6DHW5
resolver
uniprot
Q6GMY0
resolver
uniprot
Q6P4C7
resolver
uniprot
Q7L4M3
resolver
uniprot
Q96J60
resolver
uniprot_entry
K2C8_HUMAN
resolver
uniprot_entry
Q7L4M3_HUMAN
resolver
uniprot_sec
A8K4H3
resolver
uniprot_sec
B0AZN5
resolver
uniprot_sec
F8VXB4
resolver
uniprot_sec
Q14099
resolver
uniprot_sec
Q14716
resolver
uniprot_sec
Q14717
resolver
uniprot_sec
Q53GJ0
resolver
uniprot_sec
Q6DHW5
resolver
uniprot_sec
Q6GMY0
resolver
uniprot_sec
Q6P4C7
resolver
uniprot_sec
Q96J60
resolver
amino_acid_sequence
MSIRVTQKSYKVSTSGPRAFSSRSYTSGPGSRISSSSFSRVGSSNFRGGLGGGYGGASGMGGITAVTVNQSLLSPLVLEVDPNIQAVRTQEKEQIKTLNNKFASFIDKVRFLEQQNKMLETKWSLLQQQKTARSNMDNMFESYINNLRRQLETLGQEKLKLEAELGNMQGLVEDFKNKYEDEINKRTEMENEFVLIKKDVDEAYMNKVELESRLEGLTDEINFLRQLYEEEIRELQSQISDTSVVLSMDNSRSLDMDSIIAEVKAQYEDIANRSRAEAESMYQIKYEELQSLAGKHGDDLRRTKTEISEMNRNISRLQAEIEGLKGQRASLEAAIADAEQRGELAIKDANAKLSELEAALQRAKQDMARQLREYQELMNVKLALDIEIATYRKLLEGEESRLESGMQNMSIHTKTTSGYAGGLSSAYGGLTSPGLSYSLGSSFGSGAGSSSFSRTSSSRAVVVKKIETRDGKLVSESSDVLPK
uniprot
proteins
function
FUNCTION: Structural component of intermediate filaments in simple epithelial cells. Together with its obligate type I partner KRT18, contributes to the formation of the keratin intermediate filament network that provides mechanical stability and resilience to epithelial cells (PubMed:26823019). Also involved in maintaining epithelial integrity and protecting cells from non-mechanical stress, such as apoptosis (By similarity). Also required for ARHGEF40-mediated actin stress fiber formation and tensional force-induced stress fiber formation and reinforcement (PubMed:26823019). In striated muscle, together with KRT19, may contribute to linking the contractile apparatus to dystrophin at the costameres (PubMed:16000376). {ECO:0000250|UniProtKB:P11679, ECO:0000269|PubMed:16000376, ECO:0000269|PubMed:26823019}.
uniprot
proteins
mass_dalton
53704
uniprot
proteins
mutagenesis
MUTAGEN 72; /note="L->P: Increases phosphorylation."; /evidence="ECO:0000269|PubMed:11788583"; MUTAGEN 74; /note="S->A: Generates normal-appearing filaments, that remain stable after okadaic acid treatment."; /evidence="ECO:0000269|PubMed:11788583"; MUTAGEN 74; /note="S->D: Generates normal-appearing filaments, that are destabilized by okadaic acid."; /evidence="ECO:0000269|PubMed:11788583
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Ser-74 phosphorylation plays an important role in keratin filament reorganization. {ECO:0000269|PubMed:11781324, ECO:0000269|PubMed:11788583, ECO:0000269|PubMed:1374067, ECO:0000269|PubMed:9054461}.; PTM: O-glycosylated. O-GlcNAcylation at multiple sites increases solubility, and decreases stability by inducing proteasomal degradation.; PTM: O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
10809736
uniprot
proteins
pubmed
10852826
uniprot
proteins
pubmed
10973561
uniprot
proteins
pubmed
11781324
uniprot
proteins
pubmed
11788583
uniprot
proteins
pubmed
12724528
uniprot
proteins
pubmed
1371281
uniprot
proteins
pubmed
1374067
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15731013
uniprot
proteins
pubmed
15846844
uniprot
proteins
pubmed
16000376
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
16608857
uniprot
proteins
pubmed
1691124
uniprot
proteins
pubmed
1692965
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
1705144
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19188445
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20729549
uniprot
proteins
pubmed
21149639
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21908771
uniprot
proteins
pubmed
22967762
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2434381
uniprot
proteins
pubmed
2471065
uniprot
proteins
pubmed
24940650
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
26823019
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
9054461
uniprot
proteins
pubmed
9150948
uniprot
proteins
sequence_length
483
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10973561, ECO:0000269|PubMed:19188445}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q10758}. Nucleus matrix {ECO:0000250|UniProtKB:Q10758}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:26823019}.
uniprot
proteins