Tal1
entrez
21349
canonical
uniprot
P22091
canonical
ensembl
ENSMUSG00000028717
resolver
ensp
ENSMUSP00000030489
resolver
ensp
ENSMUSP00000124983
resolver
ensp
ENSMUSP00000125202
resolver
ensp
ENSMUSP00000241601
resolver
ensp
ENSMUSP00000241602
resolver
enst
ENSMUST00000030489
resolver
enst
ENSMUST00000161601
resolver
enst
ENSMUST00000162489
resolver
genesymbol
Tal1
resolver
genesymbol_syn
Scl
resolver
genesymbol_syn
Tal-1
resolver
uniprot
Q3TZH7
resolver
uniprot_entry
Q3TZH7_MOUSE
resolver
uniprot_entry
TAL1_MOUSE
resolver
amino_acid_sequence
MTERPPSEAARSDPQLEGQDAAEARMAPPHLVLLNGVAKETSRAAPAEPPVIELGARSGAGGGPASGGGAARDLKGRDAVAAEARLRVPTTELCRPPGPAPAPAPASAPAELPGDGRMVQLSPPALAAPAGPGRALLYSLSQPLASLGSGFFGEPDAFPMFTNNNRVKRRPSPYEMEISDGPHTKVVRRIFTNSRERWRQQNVNGAFAELRKLIPTHPPDKKLSKNEILRLAMKYINFLAKLLNDQEEEGTQRAKPGKDPVVGAGGGGAGGGIPPEDLLQDVLSPNSSCGSSLDGAASPDSYTEEPTPKHTSRSLHPALLPAADGAGPR
uniprot
proteins
function
FUNCTION: Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation. {ECO:0000269|PubMed:9391090}.
uniprot
proteins
mass_dalton
34279
uniprot
proteins
mutagenesis
MUTAGEN 122; /note="S->A: Remains stable, even in the face of severe hypoxia."; /evidence="ECO:0000269|PubMed:11904294
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine residues. Phosphorylation of Ser-122 by MAPK is strongly stimulated by hypoxia. {ECO:0000269|PubMed:11904294}.; PTM: Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells. {ECO:0000269|PubMed:11904294}.
uniprot
proteins
pubmed
11904294
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16407974
uniprot
proteins
pubmed
1704135
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23980096
uniprot
proteins
pubmed
9391090
uniprot
proteins
sequence_length
329
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:9391090}.
uniprot
proteins