MEAF6
entrez
64769
canonical
uniprot
Q9HAF1
canonical
ensembl
ENSG00000163875
resolver
ensp
ENSP00000296214
resolver
ensp
ENSP00000362164
resolver
ensp
ENSP00000362166
resolver
ensp
ENSP00000394966
resolver
ensp
ENSP00000649921
resolver
genesymbol
MEAF6
resolver
genesymbol_syn
C1orf149
resolver
genesymbol_syn
CENP-28
resolver
genesymbol_syn
EAF6
resolver
hgnc
HGNC:25674
resolver
uniprot
B1AK64
resolver
uniprot
Q4F967
resolver
uniprot
Q7Z311
resolver
uniprot
Q86WE3
resolver
uniprot_entry
EAF6_HUMAN
resolver
uniprot_sec
B1AK64
resolver
uniprot_sec
Q4F967
resolver
uniprot_sec
Q7Z311
resolver
uniprot_sec
Q86WE3
resolver
amino_acid_sequence
MAMHNKAAPPQIPDTRRELAELVKRKQELAETLANLERQIYAFEGSYLEDTQMYGNIIRGWDRYLTNQKNSNSKNDRRNRKFKEAERLFSKSSVTSAAAVSALAGVQDQLIEKREPGSGTESDTSPDFHNQENEPSQEDPEDLDGSVQGVKPQKAASSTSSGSHHSSHKKRKNKNRHRIDLKLNKKPRADY
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving MEAF6 may be a cause of endometrial stromal tumors. Translocation t(1;6)(p34;p21) with PHF1. {ECO:0000269|PubMed:22761769}.
uniprot
proteins
function
FUNCTION: Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A (PubMed:14966270). This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription (PubMed:14966270). Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653, PubMed:24065767). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:18794358). {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:18794358, ECO:0000269|PubMed:24065767}.
uniprot
proteins
mass_dalton
21635
uniprot
proteins
protein_family
EAF6 family
uniprot
proteins
pubmed
12601173
uniprot
proteins
pubmed
12963728
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14966270
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15647280
uniprot
proteins
pubmed
16387653
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18794358
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20813266
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22761769
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24065767
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
191
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:18794358}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:20813266}.
uniprot
proteins