Calcrl
entrez
54598
canonical
uniprot
Q9R1W5
canonical
ensembl
ENSMUSG00000059588
resolver
ensp
ENSMUSP00000073875
resolver
enst
ENSMUST00000074262
resolver
genesymbol
Calcrl
resolver
genesymbol_syn
Crlr
resolver
uniprot
A2AR99
resolver
uniprot
Q9QXH8
resolver
uniprot
Q9WUP2
resolver
uniprot_entry
A2AR99_MOUSE
resolver
uniprot_entry
CALRL_MOUSE
resolver
uniprot_sec
Q9QXH8
resolver
uniprot_sec
Q9WUP2
resolver
amino_acid_sequence
MDKKHILCFLVLLPLNMALISAESEEGVNQTDLGVTRNKIMTAQYECYQKIMQDPIQQAEGLYCNRTWDGWLCWNDVAAGTESMQYCPDYFQDFDPSEKVTKICDQDGHWFRHPDSNRTWTNYTLCNNSTHEKVKTALNLFYLTIIGHGLSIASLIISLIIFFYFKSLSCQRITLHKNLFFSFICNSIVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGVYLHTLIVVAVFAEKQHLMWYYFLGWGFPLLPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVTHQVESNLYMKAVRATLILVPLLGIEFVLFPWRPEGKVAEEVYDYVMHILMHFQGLLVATIFCFFNGEVQAILRRNWNQYKIQFGNGFSHSDALRSASYTVSTISDMQGYSHDCPTEHLNGKSIQDIENVALKSENMYDLVM
uniprot
proteins
function
FUNCTION: G protein-coupled receptor which specificity is determined by its interaction with receptor-activity-modifying proteins (RAMPs). Together with RAMP1, form the receptor complex for calcitonin-gene-related peptides CALCA/CGRP1 and CALCB/CGRP2. Together with RAMP2 or RAMP3, function as receptor complexes for adrenomedullin (ADM and ADM2). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway. {ECO:0000250|UniProtKB:Q16602}.
uniprot
proteins
mass_dalton
53265
uniprot
proteins
protein_family
G protein-coupled receptor 2 family
uniprot
proteins
pubmed
10777702
uniprot
proteins
pubmed
12147211
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
463
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q16602}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q16602}.
uniprot
proteins
transmembrane_region
TRANSMEM 139..163; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q16602"; TRANSMEM 175..197; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q16602"; TRANSMEM 209..237; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q16602"; TRANSMEM 252..272; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q16602"; TRANSMEM 289..313; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q16602"; TRANSMEM 329..350; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q16602"; TRANSMEM 366..386; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q16602
uniprot
proteins