CYREN
entrez
78996
canonical
uniprot
Q9BWK5
canonical
ensembl
ENSG00000122783
resolver
ensp
ENSP00000376823
resolver
ensp
ENSP00000473365
resolver
ensp
ENSP00000480430
resolver
ensp
ENSP00000481014
resolver
ensp
ENSP00000543664
resolver
ensp
ENSP00000543665
resolver
ensp
ENSP00000543666
resolver
ensp
ENSP00000543667
resolver
ensp
ENSP00000543668
resolver
ensp
ENSP00000608719
resolver
ensp
ENSP00000659151
resolver
ensp
ENSP00000659152
resolver
ensp
ENSP00000681070
resolver
ensp
ENSP00000681079
resolver
ensp
ENSP00000681080
resolver
ensp
ENSP00000791590
resolver
genesymbol
CYREN
resolver
genesymbol_syn
C7orf49
resolver
genesymbol_syn
MRI
resolver
hgnc
HGNC:22432
resolver
uniprot
A0A024R780
resolver
uniprot
A0A087WWQ8
resolver
uniprot
Q6NWZ4
resolver
uniprot
Q6ZNR5
resolver
uniprot_entry
CYREN_HUMAN
resolver
uniprot_sec
A0A024R780
resolver
uniprot_sec
A0A087WWQ8
resolver
uniprot_sec
Q6NWZ4
resolver
uniprot_sec
Q6ZNR5
resolver
amino_acid_sequence
METLQSETKTRVLPSWLTAQVATKNVAPMKAPKRMRMAAVPVAAARLPATRTVYCMNEAEIVDVALGILIESRKQEKACEQPALAGADNPEHSPPCSVSPHTSSGSSSEEEDSGKQALAPGLSPSQRPGGSSSACSRSPEEEEEEDVLKYVREIFFS
uniprot
proteins
function
FUNCTION: Cell-cycle-specific regulator of classical non-homologous end joining (NHEJ) of DNA double-strand break (DSB) repair, which can act both as an activator or inhibitor of NHEJ, depending on the cell cycle phase (PubMed:24610814, PubMed:28959974). Acts as a regulator of DNA repair pathway choice by specifically inhibiting classical NHEJ during the S and G2 phases, thereby promoting error-free repair by homologous recombination during cell cycle phases when sister chromatids are present (PubMed:28959974). Preferentially protects single-stranded overhangs at break sites by inhibiting classical NHEJ, thereby creating a local environment that favors homologous recombination (PubMed:28959974). Acts via interaction with XRCC5/Ku80 and XRCC6/Ku70 (PubMed:28959974). In contrast, acts as an activator of NHEJ during G1 phase of the cell cycle: promotes classical NHEJ in G1 phase cells via multivalent interactions that increase the affinity of DNA damage response proteins for DSB-associated chromatin. Also involved in immunoglobulin V(D)J recombination (By similarity). May also act as an indirect regulator of proteasome (By similarity). {ECO:0000250|UniProtKB:Q09HN1, ECO:0000250|UniProtKB:Q8BHZ5, ECO:0000269|PubMed:24610814, ECO:0000269|PubMed:28959974}.
uniprot
proteins
mass_dalton
16829
uniprot
proteins
mutagenesis
MUTAGEN 11; /note="R->A: Abolishes interaction with XRCC5/Ku80 and XRCC6/Ku70 and ability to inhibit classical non-homologous end joining (NHEJ)."; /evidence="ECO:0000269|PubMed:28959974"; MUTAGEN 14; /note="P->A: Abolishes interaction with XRCC5/Ku80 and XRCC6/Ku70 and ability to inhibit classical non-homologous end joining (NHEJ)."; /evidence="ECO:0000269|PubMed:28959974"; MUTAGEN 16; /note="W->A: Abolishes interaction with XRCC5/Ku80 and XRCC6/Ku70 and ability to inhibit classical non-homologous end joining (NHEJ). Does not affect interaction with SF3B1."; /evidence="ECO:0000269|PubMed:27063109, ECO:0000269|PubMed:28959974, ECO:0000269|PubMed:37813856"; MUTAGEN 71; /note="E->A: Does not affect interaction with SF3B1."; /evidence="ECO:0000269|PubMed:37813856"; MUTAGEN 153; /note="E->A: Abolishes interaction with SF3B1."; /evidence="ECO:0000269|PubMed:37813856
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24610814
uniprot
proteins
pubmed
27063109
uniprot
proteins
pubmed
28959974
uniprot
proteins
pubmed
31733588
uniprot
proteins
pubmed
32355287
uniprot
proteins
pubmed
37813856
uniprot
proteins
sequence_length
157
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:24610814}. Nucleus {ECO:0000269|PubMed:24610814}. Chromosome {ECO:0000269|PubMed:27063109}. Note=Nuclear localization may depend upon interaction with XRCC5/Ku80 and XRCC6/Ku70 heterodimer (PubMed:24610814). Localizes to DNA damage sites (PubMed:27063109). {ECO:0000269|PubMed:24610814, ECO:0000269|PubMed:27063109}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:24610814}. Note=Some nuclear localization may be due to passive diffusion. {ECO:0000269|PubMed:24610814}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000269|PubMed:24610814}. Nucleus {ECO:0000269|PubMed:24610814}. Note=Nuclear localization may depend upon interaction with XRCC5/Ku80 and XRCC6/Ku70 heterodimer and increases upon etoposide treatment. {ECO:0000269|PubMed:24610814}.
uniprot
proteins