SIRT3
entrez
23410
canonical
uniprot
Q9NTG7
canonical
ensembl
ENSG00000142082
resolver
ensp
ENSP00000372191
resolver
ensp
ENSP00000432937
resolver
ensp
ENSP00000433077
resolver
ensp
ENSP00000435464
resolver
ensp
ENSP00000437216
resolver
ensp
ENSP00000522990
resolver
ensp
ENSP00000522994
resolver
ensp
ENSP00000523001
resolver
enst
ENST00000524564
resolver
enst
ENST00000525319
resolver
enst
ENST00000532956
resolver
genesymbol
SIRT3
resolver
genesymbol_syn
SIR2L3
resolver
hgnc
HGNC:14931
resolver
uniprot
B7Z5U6
resolver
uniprot
E9PK80
resolver
uniprot
E9PM75
resolver
uniprot
E9PN58
resolver
uniprot
Q9Y6E8
resolver
uniprot_entry
E9PK80_HUMAN
resolver
uniprot_entry
E9PM75_HUMAN
resolver
uniprot_entry
E9PN58_HUMAN
resolver
uniprot_entry
SIR3_HUMAN
resolver
uniprot_sec
B7Z5U6
resolver
uniprot_sec
Q9Y6E8
resolver
amino_acid_sequence
MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEPLDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDKGKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
ec_number
2.3.1.286
uniprot
proteins
function
FUNCTION: NAD-dependent protein deacetylase (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:19535340, PubMed:23283301, PubMed:24121500, PubMed:24252090). Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed:12186850, PubMed:12374852, PubMed:16788062, PubMed:18680753, PubMed:18794531, PubMed:23283301, PubMed:24121500, PubMed:24252090, PubMed:38146092). Known targets include ACSS1, IDH, GDH, SOD2, PDHA1, LCAD, SDHA, MRPL12 and the ATP synthase subunit ATP5PO (PubMed:16788062, PubMed:18680753, PubMed:19535340, PubMed:24121500, PubMed:24252090, PubMed:38146092). Contributes to the regulation of the cellular energy metabolism (PubMed:24252090). Important for regulating tissue-specific ATP levels (PubMed:18794531). In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed:23283301). Acts as a regulator of ceramide metabolism by mediating deacetylation of ceramide synthases CERS1, CERS2 and CERS6, thereby increasing their activity and promoting mitochondrial ceramide accumulation (By similarity). Regulates hepatic lipogenesis (By similarity). Uses NAD(+) substrate imported by SLC25A47, triggering downstream activation of PRKAA1/AMPK-alpha signaling cascade that ultimately down-regulates sterol regulatory element-binding protein (SREBP) transcriptional activities and ATP-consuming lipogenesis to restore cellular energy balance (By similarity). In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups, such as benzoyl and lactoyl, leading to protein debenzoylation and delactylation, respectively (PubMed:39524354, PubMed:36896611, PubMed:37720100). Catalyzes debenzoylation of PPIF and ACLY (PubMed:37720100). Mediates delactylation of CCNE2 and 'Lys-16' of histone H4 (H4K16la) (PubMed:36896611, PubMed:37720100). {ECO:0000250|UniProtKB:Q8R104, ECO:0000269|PubMed:12186850, ECO:0000269|PubMed:12374852, ECO:0000269|PubMed:16788062, ECO:0000269|PubMed:18680753, ECO:0000269|PubMed:18794531, ECO:0000269|PubMed:19535340, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:24121500, ECO:0000269|PubMed:24252090, ECO:0000269|PubMed:36896611, ECO:0000269|PubMed:37720100, ECO:0000269|PubMed:38146092}.
uniprot
proteins
mass_dalton
43573
uniprot
proteins
mutagenesis
MUTAGEN 7; /note="R->G,Q: Suppresses targeting to mitochondrion; when associated with G-13 or Q-13."; /evidence="ECO:0000269|PubMed:12186850"; MUTAGEN 13; /note="R->G,Q: Suppresses targeting to mitochondrion; when associated with G-7 or Q-7."; /evidence="ECO:0000269|PubMed:12186850"; MUTAGEN 17; /note="R->G,Q: Reduces targeting to mitochondrion; when associated with G-21 or Q-21."; /evidence="ECO:0000269|PubMed:12186850"; MUTAGEN 21; /note="R->G,Q: Reduces targeting to mitochondrion; when associated with G-17 or Q-17."; /evidence="ECO:0000269|PubMed:12186850"; MUTAGEN 99..100; /note="RR->GG: Abolishes processing by MPP (in vitro)."; /evidence="ECO:0000269|PubMed:12186850"; MUTAGEN 229; /note="N->A: Loss of function."; /evidence="ECO:0000269|PubMed:12186850"; MUTAGEN 248; /note="H->Y: Loss of protein deacetylase and delactylase."; /evidence="ECO:0000269|PubMed:12186850, ECO:0000269|PubMed:16788062, ECO:0000269|PubMed:18794531, ECO:0000269|PubMed:36896611
uniprot
proteins
post_translational_modification
PTM: Processed by mitochondrial processing peptidase (MPP) to give a 28 kDa product. Such processing is probably essential for its enzymatic activity. {ECO:0000269|PubMed:12186850}.
uniprot
proteins
protein_family
Class I subfamily
uniprot
proteins
protein_family
Sirtuin family
uniprot
proteins
pubmed
10381378
uniprot
proteins
pubmed
12186850
uniprot
proteins
pubmed
12374852
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16079181
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16788062
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18215119
uniprot
proteins
pubmed
18680753
uniprot
proteins
pubmed
18794531
uniprot
proteins
pubmed
19535340
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21172655
uniprot
proteins
pubmed
23283301
uniprot
proteins
pubmed
23438705
uniprot
proteins
pubmed
23897466
uniprot
proteins
pubmed
24121500
uniprot
proteins
pubmed
24252090
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29445193
uniprot
proteins
pubmed
36896611
uniprot
proteins
pubmed
37720100
uniprot
proteins
pubmed
38146092
uniprot
proteins
pubmed
39524354
uniprot
proteins
sequence_length
399
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:12186850, ECO:0000269|PubMed:12374852, ECO:0000269|PubMed:16079181, ECO:0000269|PubMed:18215119, ECO:0000269|PubMed:23283301, ECO:0000269|PubMed:29445193}.
uniprot
proteins