Rhoa
entrez
117273
canonical
uniprot
P61589
canonical
ensembl
ENSRNOG00000050519
resolver
ensembl
ENSRNOG00055013477
resolver
ensembl
ENSRNOG00060022827
resolver
ensembl
ENSRNOG00065006590
resolver
ensp
ENSRNOP00000091658
resolver
ensp
ENSRNOP00055018751
resolver
ensp
ENSRNOP00060032811
resolver
ensp
ENSRNOP00065007446
resolver
enst
ENSRNOT00000094929
resolver
enst
ENSRNOT00055023109
resolver
enst
ENSRNOT00060039667
resolver
enst
ENSRNOT00065010200
resolver
genesymbol
Rhoa
resolver
genesymbol_syn
Arha
resolver
genesymbol_syn
Arha2
resolver
uniprot_entry
RHOA_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. Activated by GEFs such as ARHGEF2, ARHGEF3, ARHGEF28 and BCR. Activated by ARHGEF40 in response to mechanotransduction in endothelial cells (By similarity). Inhibited by GAPs such as ARHGAP30. Inhibited by GDP dissociation inhibitors such as ARHGDIA. {ECO:0000250|UniProtKB:P24406, ECO:0000250|UniProtKB:P61586}.
uniprot
proteins
amino_acid_sequence
MAAIRKKLVIVGDGACGKTCLLIVFSKDQFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSIDSPDSLENIPEKWTPEVKHFCPNVPIILVGNKKDLRNDEHTRRELAKMKQEPVKPEEGRDMANRIGAFGYMECSAKTKDGVREVFEMATRAALQARRGKKKSGCLIL
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such as cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). Involved in the reorientation of endothelial cells and their actin stress fibers in response to cellular mechantransduction-mediated activation by ARHGEF40 (By similarity). Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis (PubMed:9635436). Acts as an allosteric activator of guanine nucleotide exchange factor ECT2 by binding in its activated GTP-bound form to the PH domain of ECT2 which stimulates the release of PH inhibition and promotes the binding of substrate RHOA to the ECT2 catalytic center (By similarity). May be an activator of PLCE1 (By similarity). In neurons, involved in the inhibition of the initial spine growth. Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (PubMed:21423166). Acts as a regulator of platelet alpha-granule release during activation and aggregation of platelets (By similarity). When activated by DAAM1 may signal centrosome maturation and chromosomal segregation during cell division. May also be involved in contractile ring formation during cytokinesis. {ECO:0000250|UniProtKB:P24406, ECO:0000250|UniProtKB:P61586, ECO:0000250|UniProtKB:Q9QUI0, ECO:0000269|PubMed:21423166, ECO:0000269|PubMed:9635436}.
uniprot
proteins
mass_dalton
21782
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by PRKG1 at Ser-188 inactivates RHOA signaling (By similarity). Phosphorylation by SLK at Ser-188 in response to AGTR2 activation (PubMed:18420945). {ECO:0000250|UniProtKB:P61586, ECO:0000269|PubMed:18420945}.; PTM: Ubiquitinated by the BCR(KCTD13) and BCR(TNFAIP1) E3 ubiquitin ligase complexes, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and synaptic transmission in neurons. Ubiquitinated at Lys-135 in a FBXL19-mediated manner; leading to proteasomal degradation. {ECO:0000250|UniProtKB:P61586, ECO:0000250|UniProtKB:Q9QUI0}.; PTM: Serotonylation of Gln-63 by TGM2 during activation and aggregation of platelets leads to constitutive activation of GTPase activity. {ECO:0000250|UniProtKB:Q9QUI0}.
uniprot
proteins
protein_family
Rho family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18420945
uniprot
proteins
pubmed
21423166
uniprot
proteins
pubmed
9635436
uniprot
proteins
sequence_length
193
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P61586}; Lipid-anchor {ECO:0000250|UniProtKB:P61586}; Cytoplasmic side {ECO:0000250|UniProtKB:P61586}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P61586}. Cleavage furrow {ECO:0000250|UniProtKB:P61586}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:P61586}. Midbody {ECO:0000250|UniProtKB:P61586}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q9QUI0}. Cell projection, dendrite {ECO:0000305|PubMed:21423166}. Nucleus {ECO:0000250|UniProtKB:P61586}. Cytoplasm {ECO:0000250|UniProtKB:P61586}. Note=Localized to cell-cell contacts in calcium-treated keratinocytes (By similarity). Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. Localizes to the equatorial cell cortex (at the site of the presumptive furrow) in early anaphase in an activated form and in a myosin- and actin-independent manner. Colocalizes with KANK1 at the contractile ring. Colocalizes with DAAM1 and KANK1 around centrosomes. {ECO:0000250|UniProtKB:P61586, ECO:0000250|UniProtKB:Q9QUI0}.
uniprot
proteins