Pf4
entrez
56744
canonical
uniprot
Q9Z126
canonical
ensembl
ENSMUSG00000029373
resolver
ensp
ENSMUSP00000031320
resolver
enst
ENSMUST00000031320
resolver
genesymbol
Pf4
resolver
genesymbol_syn
Cxcl4
resolver
genesymbol_syn
Scyb4
resolver
uniprot
Q3TVN6
resolver
uniprot
Q6P8R3
resolver
uniprot_entry
PLF4_MOUSE
resolver
uniprot_entry
Q3TVN6_MOUSE
resolver
uniprot_entry
Q6P8R3_MOUSE
resolver
amino_acid_sequence
MSVAAVFRGLRPSPELLLLGLLFLPAVVAVTSAGPEESDGDLSCVCVKTISSGIHLKHITSLEVIKAGRHCAVPQLIATLKNGRKICLDRQAPLYKKVIKKILES
uniprot
proteins
function
FUNCTION: Chemokine released during platelet aggregation that plays a role in different biological processes including hematopoiesis, cell proliferation, differentiation, and activation. Acts via different functional receptors including CCR1, CXCR3A or CXCR3B. Upon interaction with CXCR3A receptor, induces activated T-lymphocytes migration mediated via downstream Ras/extracellular signal-regulated kinase (ERK) signaling. Neutralizes the anticoagulant effect of heparin by binding more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Plays a role in the inhibition of hematopoiesis and in the maintenance of hematopoietic stem cell (HSC) quiescence. Chemotactic for neutrophils and monocytes via CCR1. Inhibits endothelial cell proliferation. In cooperation with toll-like receptor 8/TLR8, induces chromatin remodeling and activates inflammatory gene expression via the TBK1-IRF5 axis. In addition, induces myofibroblast differentiation and collagen synthesis in different precursor cells, including endothelial cells, by stimulating endothelial-to-mesenchymal transition. Interacts with thrombomodulin/THBD to enhance the activation of protein C and thus potentiates its anticoagulant activity. {ECO:0000250|UniProtKB:P02776}.
uniprot
proteins
mass_dalton
11243
uniprot
proteins
protein_family
Intercrine alpha (chemokine CxC) family
uniprot
proteins
pubmed
10319581
uniprot
proteins
pubmed
11468158
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
105
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins