PSMB5
entrez
5693
canonical
uniprot
P28074
canonical
ensembl
ENSG00000100804
resolver
ensp
ENSP00000355325
resolver
ensp
ENSP00000395206
resolver
ensp
ENSP00000452424
resolver
genesymbol
PSMB5
resolver
genesymbol_syn
LMPX
resolver
genesymbol_syn
MB1
resolver
genesymbol_syn
X
resolver
hgnc
HGNC:9542
resolver
uniprot
A0A140VJS7
resolver
uniprot
B2R4N9
resolver
uniprot
B4DUM9
resolver
uniprot
D3DS43
resolver
uniprot
E9PAV2
resolver
uniprot
Q16242
resolver
uniprot
Q6PEW2
resolver
uniprot
Q7Z3B5
resolver
uniprot
Q86T01
resolver
uniprot
Q9TNN9
resolver
uniprot_entry
A0A140VJS7_HUMAN
resolver
uniprot_entry
PSB5_HUMAN
resolver
uniprot_sec
B2R4N9
resolver
uniprot_sec
B4DUM9
resolver
uniprot_sec
D3DS43
resolver
uniprot_sec
E9PAV2
resolver
uniprot_sec
Q16242
resolver
uniprot_sec
Q6PEW2
resolver
uniprot_sec
Q7Z3B5
resolver
uniprot_sec
Q86T01
resolver
uniprot_sec
Q9TNN9
resolver
amino_acid_sequence
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
uniprot
proteins
ec_number
3.4.25.1
uniprot
proteins
function
FUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity. {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:18502982, ECO:0000269|PubMed:18565852, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.
uniprot
proteins
mass_dalton
28480
uniprot
proteins
mutagenesis
MUTAGEN 108; /note="A->T: Displays resistance to the bortezomib, a proteasome inhibitor of the chymotrypsin-like activity. Displays high resistance to the bortezomib, a proteasome inhibitor of the chymotrypsin-like activity; when associated with V-109."; /evidence="ECO:0000269|PubMed:18502982, ECO:0000269|PubMed:18565852, ECO:0000269|PubMed:19426847"; MUTAGEN 108; /note="A->V: Displays high resistance to the bortezomib, a proteasome inhibitor of the chymotrypsin-like activity."; /evidence="ECO:0000269|PubMed:18502982, ECO:0000269|PubMed:18565852, ECO:0000269|PubMed:19426847"; MUTAGEN 109; /note="A->V: Displays high resistance to the bortezomib, a proteasome inhibitor of the chymotrypsin-like activity; when associated with T-108."; /evidence="ECO:0000269|PubMed:19426847
uniprot
proteins
protein_family
Peptidase T1B family
uniprot
proteins
pubmed
12181345
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14550573
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15244466
uniprot
proteins
pubmed
15488952
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15944226
uniprot
proteins
pubmed
17004105
uniprot
proteins
pubmed
17323924
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18502982
uniprot
proteins
pubmed
18565852
uniprot
proteins
pubmed
18602823
uniprot
proteins
pubmed
19426847
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2306472
uniprot
proteins
pubmed
23495936
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25599644
uniprot
proteins
pubmed
26133119
uniprot
proteins
pubmed
27176742
uniprot
proteins
pubmed
27342858
uniprot
proteins
pubmed
27428775
uniprot
proteins
pubmed
27493187
uniprot
proteins
pubmed
34711951
uniprot
proteins
pubmed
7811265
uniprot
proteins
pubmed
7820546
uniprot
proteins
pubmed
7864893
uniprot
proteins
pubmed
8066462
uniprot
proteins
pubmed
8163024
uniprot
proteins
pubmed
8610016
uniprot
proteins
pubmed
8663318
uniprot
proteins
pubmed
8753855
uniprot
proteins
sequence_length
263
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Nucleus {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000269|PubMed:34711951}.
uniprot
proteins