Mad2l2
entrez
71890
canonical
uniprot
Q9D752
canonical
ensembl
ENSMUSG00000029003
resolver
ensp
ENSMUSP00000030860
resolver
ensp
ENSMUSP00000081146
resolver
ensp
ENSMUSP00000101332
resolver
ensp
ENSMUSP00000122774
resolver
ensp
ENSMUSP00000237047
resolver
ensp
ENSMUSP00000237049
resolver
ensp
ENSMUSP00000237050
resolver
ensp
ENSMUSP00000237051
resolver
ensp
ENSMUSP00000237052
resolver
ensp
ENSMUSP00000237054
resolver
ensp
ENSMUSP00000332359
resolver
ensp
ENSMUSP00000348266
resolver
ensp
ENSMUSP00000348267
resolver
ensp
ENSMUSP00000348268
resolver
enst
ENSMUST00000030860
resolver
enst
ENSMUST00000084129
resolver
enst
ENSMUST00000105707
resolver
genesymbol
Mad2l2
resolver
genesymbol_syn
Mad2b
resolver
genesymbol_syn
Rev7
resolver
uniprot
A2A7G7
resolver
uniprot
Q3TMY6
resolver
uniprot
Q91VP1
resolver
uniprot_entry
A2A7G7_MOUSE
resolver
uniprot_entry
MD2L2_MOUSE
resolver
uniprot_sec
Q3TMY6
resolver
uniprot_sec
Q91VP1
resolver
amino_acid_sequence
MTTLTRQDLNFGQVVADVLSEFLEVAVHLILYVREVYPVGIFQKRKKYNVPVQMSCHPELNQYIQDTLHCVKPLLEKNDVEKVVVVILDKEHRPVEKFVFEITQPPLLSINSDSLLSHVEQLLRAFILKISVCDAVLDHNPPGCTFTVLVHTREAATRNMEKIQVIKDFPWILADEQDVHMHDPRLIPLKTMTSDILKMQLYVEERAHKNS
uniprot
proteins
function
FUNCTION: Adapter protein able to interact with different proteins and involved in different biological processes (By similarity). Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis (PubMed:22859295). Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres. May also regulate another aspect of cellular response to DNA damage through regulation of the JNK-mediated phosphorylation and activation of the transcriptional activator ELK1. Inhibits the FZR1- and probably CDC20-mediated activation of the anaphase promoting complex APC thereby regulating progression through the cell cycle. Regulates TCF7L2-mediated gene transcription and may play a role in epithelial-mesenchymal transdifferentiation. Forms a quaternary complex with POLK, REV1 and REV3L, where REV3L-bound MAD2L2 and POLK are able to bind simultaneously to REV1 forming the stable translesion synthesis (TLS) machinery therefore bridging the inserter and extender polymerases (PubMed:22859295). {ECO:0000250|UniProtKB:Q9UI95, ECO:0000269|PubMed:22859295}.
uniprot
proteins
mass_dalton
24402
uniprot
proteins
pubmed
14657033
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
22859295
uniprot
proteins
sequence_length
211
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UI95}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9UI95}. Cytoplasm {ECO:0000250|UniProtKB:Q9UI95}. Chromosome {ECO:0000250|UniProtKB:Q9UI95}. Note=Recruited to sites of chromosomal double-stranded breaks during G1 and S phase of the cell cycle. {ECO:0000250|UniProtKB:Q9UI95}.
uniprot
proteins