Tmem17
entrez
103765
canonical
uniprot
Q8K0U3
canonical
ensembl
ENSMUSG00000049904
resolver
ensp
ENSMUSP00000051414
resolver
enst
ENSMUST00000059319
resolver
genesymbol
Tmem17
resolver
uniprot_entry
TMM17_MOUSE
resolver
amino_acid_sequence
MELPDPVRQRLSNLSLTVFGDSSRTGPESSDAADNEMVSSLALQMSLYFNSYFFPLWWVSCIVMLHLKYSILPDYYKFIVVTVVILITLIEAIRLYLGCMGNLQEKVPELAGFWLLSLLLQLPLILFLLLNDGLRNLPLEKAIHIIFTIFLTFQVISAFLTLKKMVNQLAARFHLQDFDQLSSSSAAVRRVRQCTEEL
uniprot
proteins
function
FUNCTION: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling. {ECO:0000269|PubMed:22179047}.
uniprot
proteins
mass_dalton
22623
uniprot
proteins
protein_family
TMEM17 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22179047
uniprot
proteins
sequence_length
198
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000269|PubMed:22179047}; Multi-pass membrane protein {ECO:0000269|PubMed:22179047}. Note=Localizes to the transition zone of primary cilia.
uniprot
proteins
transmembrane_region
TRANSMEM 47..67; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 78..98; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 110..130; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 142..162; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins