Nsg1
entrez
25247
canonical
uniprot
P02683
canonical
ensembl
ENSRNOG00000005700
resolver
ensembl
ENSRNOG00055016246
resolver
ensembl
ENSRNOG00060019873
resolver
ensembl
ENSRNOG00065028848
resolver
ensp
ENSRNOP00000097258
resolver
ensp
ENSRNOP00055022135
resolver
ensp
ENSRNOP00060028221
resolver
ensp
ENSRNOP00065040884
resolver
enst
ENSRNOT00000118922
resolver
enst
ENSRNOT00055027584
resolver
enst
ENSRNOT00060034389
resolver
enst
ENSRNOT00065049796
resolver
genesymbol
Nsg1
resolver
genesymbol_syn
Bsmrb
resolver
uniprot
P02684
resolver
uniprot
Q6P9Y0
resolver
uniprot_entry
NSG1_RAT
resolver
uniprot_sec
P02684
resolver
uniprot_sec
Q6P9Y0
resolver
amino_acid_sequence
MVKLGNNFAEKGTKQPLLEDGFDTIPLMTPLDVNQLQFPPPDKVVVKTKTEYEPDRKKGKARPPKIAEFTVSITEGVTERFKVSVLVLFALAFLTCVVFLVVYKVYKYDRACPDGFVLKNTQCIPEGLESYYTEQDSSAREKFYTVINHYNLAKQSITRSVSPWMSVLSEEKLSEQETEAAEKSA
uniprot
proteins
function
FUNCTION: Plays a role in the recycling mechanism in neurons of multiple receptors, including AMPAR, APP and L1CAM and acts at the level of early endosomes to promote sorting of receptors toward a recycling pathway (PubMed:15911354, PubMed:18299352). Regulates sorting and recycling of GRIA2 through interaction with GRIP1 and then contributes to the regulation of synaptic transmission and plasticity by affecting the recycling and targeting of AMPA receptors to the synapse (PubMed:15911354). Is required for faithful sorting of L1CAM to axons by facilitating trafficking from somatodendritic early endosome or the recycling endosome (PubMed:18299352). In an other hand, induces apoptosis via the activation of CASP3 in response to DNA damage (By similarity). {ECO:0000250|UniProtKB:P42857, ECO:0000269|PubMed:15911354, ECO:0000269|PubMed:18299352}.
uniprot
proteins
mass_dalton
20943
uniprot
proteins
protein_family
NSG family
uniprot
proteins
pubmed
12070131
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15911354
uniprot
proteins
pubmed
16037816
uniprot
proteins
pubmed
18299352
uniprot
proteins
pubmed
28874679
uniprot
proteins
pubmed
6347394
uniprot
proteins
pubmed
9013775
uniprot
proteins
pubmed
9461575
uniprot
proteins
sequence_length
185
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:28874679}; Single-pass type II membrane protein {ECO:0000269|PubMed:28874679}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:28874679}. Endosome membrane {ECO:0000269|PubMed:18299352, ECO:0000269|PubMed:28874679}. Cell projection, dendrite {ECO:0000269|PubMed:12070131, ECO:0000269|PubMed:28874679}. Early endosome membrane {ECO:0000269|PubMed:12070131, ECO:0000269|PubMed:28874679}. Late endosome membrane {ECO:0000269|PubMed:28874679}. Lysosome lumen {ECO:0000269|PubMed:28874679}. Recycling endosome membrane {ECO:0000269|PubMed:12070131}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:9461575}. Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:9461575}. Endosome, multivesicular body membrane {ECO:0000269|PubMed:9461575}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P42857}. Note=Endocytosed from the cell surface, thus enters into early endosomes, trafficks to late endosomes and degradates in lysosomes (PubMed:28874679). Endoplasmic reticulum targeting is essential for apoptosis (By similarity). Found in both stationary and motile endosomes. A previous study supports a type I membrane protein topology (By similarity). {ECO:0000250|UniProtKB:P42857, ECO:0000250|UniProtKB:Q62092, ECO:0000269|PubMed:28874679}.
uniprot
proteins
transmembrane_region
TRANSMEM 83..103; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins