Q8K3A4
uniprot
Q8K3A4
canonical
amino_acid_sequence
MPPKKRRRQSQKAQLLFHQQPLEGPKHHYESCQQPITHTVQVPSKPIDQSTVTSWVSPQFDRAAESRFLIHWKPHRDQARRPTRRSTCKFPRLTFESPQSSSSETLLLSNRVQPQNSEKDPPRRPLVPLFSPQSCGELSVHVPHSLPHVFAPPDIQTPDSSVRDDPISPDQKENSFPSCILGPGTPSSPEPGPVLVKDTPEEKYGIKVTWRRRRHLFAYLKEKGKLDGSQFLVKI
uniprot
proteins
function
FUNCTION: Involved in microhomology-mediated end-joining (MMEJ) DNA repair by promoting recruitment of polymerase theta (POLQ) to DNA damage sites during mitosis. MMEJ is an alternative non-homologous end-joining (NHEJ) machinery that takes place during mitosis to repair double-strand breaks in DNA that originate in S-phase. Accumulates in M-phase; following phosphorylation by PLK1, interacts with POLQ, enabling its recruitment to double-strand breaks for subsequent repair. Also involved in the DNA damage response (DDR) signaling in response to genotoxic stresses such as ionizing radiation (IR) during the S phase. Recruited to sites of DNA damage through interaction with the 9-1-1 cell-cycle checkpoint response complex and TOPBP1 in a ATR-dependent manner. Required for the progression of the G1 to S phase transition. Plays a role in the stimulation of CHEK1 phosphorylation. {ECO:0000250|UniProtKB:Q9BSD3}.
uniprot
proteins
mass_dalton
26820
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-50 by PLK1, promoting interaction with polymerase theta (POLQ). {ECO:0000250|UniProtKB:Q9BSD3}.; PTM: Ubiquitinated and degraded by the APC/C complex upon mitotic exit. {ECO:0000250|UniProtKB:Q9BSD3}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
235
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BSD3}. Chromosome {ECO:0000250|UniProtKB:Q9BSD3}. Note=Localizes to sites of DNA damage in a H2AX-independent manner. {ECO:0000250|UniProtKB:Q9BSD3}.
uniprot
proteins