P35689
uniprot
P35689
canonical
amino_acid_sequence
MGVQGLWKLLECSGHRVSPEALEGKVLAVDISIWLNQALKGVRDSHGNVIENAHLLTLFHRLCKLLFFRIRPIFVFDGDAPLLKKQTLAKRRQRKDSASIDSRKTTEKLLKTFLKRQALKTAFRSSRHEAPPSLTQVQRQDDIYVLPPLPEEEKHSSEEEDEKQWQARMDQKQALQEEFFHNPQAIDIESEDFSSLPPEVKHEILTDMKEFTKRRRTLFEAMPEESNDFSQYQLKGLLKKNYLNQHIENVQKEMNQQHSGQIQRQYQDEGGFLKEVESRRVVSEDTSHYILIKGIQGKKVMDVDSESLPSSSNVHSVSSNLKSSPHEKVKPEREPEAAPPSPRTLLAIQAAMLGSSSEDEPESREGRQSKERNSGATADAGSISPRTCAAIQKALDDDNDEKVSGSSDDLAEKMLLGSGLEQEEHADETAERGGGVPFDTAPLTPSVTEVKECVTSGSSANGQTDSAHSFTTASHRCDTPKETVSLARAVKEASQISSECEVEGRPAALSPAFIGTPSSHVSGVLSEREPTLAPPTTRTHSDQGIDIHPEDPELQNGLYPLETKCNSSRLSSDDETEGGQNPAPKACSTVHVPAEAMSNLENALPSNAEERGDFQETIQLREVPEAAARELISAPKPMGPMEMESEESESDGSFIEVQSVVSNSELQTESSEASTHLSEKDAEEPRETLEEGTSRDTECLLQDSSDIEAMEGHREADIDAEDMPNEWQDINLEELDALESNLLAEQNSLKAQKQQQDRIAASVTGQMFLESQELLRLFGVPYIQAPMEAEAQCAMLDLTDQTSGTITDDSDIWLFGARHVYKNFFNKNKFVEYYQYVDFYSQLGLDRNKLINLAYLLGSDYTEGIPTVGCVTAMEILNEFPGRGLDPLLKFSEWWHEAQNNKKVAENPYDTKVKKKLRKLQLTPGFPNPAVADAYLRPVVDDSRGSFLWGKPDVDKISTFCQRYFGWNRMKTDESLYPVLKHLNAHQTQLRIDSFFRLAQQEKQDAKLIKSHRLNRAVTCILRKEREEKAPELTKVTEALDDAKGKTQKRELPYKKETSVPKRRRPSGNGGFLGDPYCSESPQESSCEDGEGSSVMSARQRSAAESSKISCSDVPDLVRDPPHGRQGCVSTSSSSEDDEDKAKTVLVTARPVFGKKKLKLKSMKRRKKKT
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Binds and bends DNA repair bubble substrate and breaks base stacking at the single-strand/double-strand DNA junction of the DNA bubble. Plays a role in base excision repair (BER) by promoting the binding of DNA glycosylase NTHL1 to its substrate and increasing NTHL1 catalytic activity that removes oxidized pyrimidines from DNA. Involved in transcription-coupled nucleotide excision repair (TCR) which allows RNA polymerase II-blocking lesions to be rapidly removed from the transcribed strand of active genes. Functions during the initial step of TCR in cooperation with ERCC6/CSB to recognized stalled RNA polymerase II. Also, stimulates ERCC6/CSB binding to the DNA repair bubble and ERCC6/CSB ATPase activity. Required for DNA replication fork maintenance and preservation of genomic stability. Involved in homologous recombination repair (HRR) induced by DNA replication stress by recruiting RAD51, BRCA2, and PALB2 to the damaged DNA site. During HRR, binds to the replication fork with high specificity and stabilizes it. Also, acts upstream of HRR, to promote the release of BRCA1 from DNA. {ECO:0000250|UniProtKB:P28715}.
uniprot
proteins
mass_dalton
130715
uniprot
proteins
protein_family
XPG subfamily
uniprot
proteins
protein_family
XPG/RAD2 endonuclease family
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7510366
uniprot
proteins
pubmed
7590748
uniprot
proteins
pubmed
8703115
uniprot
proteins
sequence_length
1170
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P28715}. Chromosome {ECO:0000250|UniProtKB:P28715}. Note=Colocalizes with RAD51 to nuclear foci in S phase. Localizes to DNA double-strand breaks (DSB) during replication stress. Colocalizes with BRCA2 to nuclear foci following DNA replication stress. {ECO:0000250|UniProtKB:P28715}.
uniprot
proteins