Plxna3
entrez
18846
canonical
uniprot
P70208
canonical
ensembl
ENSMUSG00000031398
resolver
ensp
ENSMUSP00000004326
resolver
genesymbol
Plxna3
resolver
uniprot
A5D6Q5
resolver
uniprot
Q684J0
resolver
uniprot
Q8BWZ5
resolver
uniprot_entry
PLXA3_MOUSE
resolver
uniprot_sec
A5D6Q5
resolver
uniprot_sec
Q684J0
resolver
uniprot_sec
Q8BWZ5
resolver
amino_acid_sequence
MPTVCLLPLLFFTIGGCLGSSRPFRTFVVTDTTLTHLAVHRVTGEVFVGAVNRVFKLAPNLTELRAHVTGPIEDNARCYPPPSMRVCSHRLVPVDNVNKLLLIDYAARRLVACGSIWQGICQFLRLDDLFKLGEPHHRKEHYLSGAQEPDSMAGVIVEQVQGPSKLFVGTAVDGKSEYFPTLSSRKLIDDEDSGDMFSLVYQDEFVSSQIKIPSDTLSLYPAFDIYYIYGFVSASFVYFLTLQLDTQQTLLDTAGEKFFTSKIVRMCAGDSEFYSYVEFPIGCSWRGVEYRLVQSAHLAKPGLLLAQALGVPADEDVLFTIFSQGQKNRANPPRQTILCLFTLSSINAHIRRRIQSCYRGEGTLALPWLLNKELPCINTPLQINGNFCGLVLNQPLGGLHVIEGLPLLADSTDGMASVAAYTYHQHSVVFIGTRSGNLKKVRVDGSQDAQLYETVSVVQGSPILRDLLFSPDHRHIYLLSEKQVSQLPVETCEQYLSCAACLGSGDPHCGWCVLQHRCCREGACPGASAPHGFAEELSKCIQVRVRPNNVSVTSSGVQLTVAMRNVPDLSVGVSCSFEEVTESEAILLPSGELRCPSPSLQELQTLTRGHGATHTVRLQLLSMETGVRFAGVDFVFYNCSALQSCMSCVGSPYPCHWCKYRHVCTSHPHECSFQEGRVHSPEGCPEILPQGDLLIPVGVMQPLTLRAKNLPQPQSGQKNYECVVRVQGRQHRVPAVRFNSSSVQCQNASYFYEGDEFGDTELDFSVVWDGDFPIDKPPSFRALLYKCWAQRPSCGLCLKADPRFNCGWCISEHRCQLRAHCPAPKSNWMHPSQKGARCSHPRITQIHPLTGPKEGGTRVTIVGENLGLTSREVGLRVAGVRCNSIPTEYVSAERIVCEMEESLVPSPPPGPAELCVGDCSADFRTQSQQLYSFVTPTFDRVSPSRGPASGGTRLTISGISLDAGSRVTVIIRDGECQFVRRDAEAIVCISPVSTLGPSQSPITLAIDHANISNTGVIYTYTQDPTVTHLEPTWSIINGSTSITVSGTHLLTVQEPRVRAKYRGIETTNTCQVINDTAMLCKAPGIFLGHPQPRAQGEHPDEFGFLLDHVQAARSLNRSSFTYYPDPSFEPLGPSGVLDVKPGSHVVLKGKNLIPAAAGSSRLNYTVLIGGQPCALTVSDTQLLCDSPSQTGRQPVMVLVGGLEFWLGTLHITADRALTLPAMVGLAAGGGLLLLAITVVLVAYKRKTQDADRTLKRLQLQMDNLESRVALECKEAFAELQTDINELTNHMDGVQIPFLDYRTYAVRVLFPGIEAHPVLKELDTPPNVEKALRLFGQLLHSRAFLLTFIHTLEAQSSFSMRDRGTVASLTMVALQSRLDYATGLLKQLLADLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLHCVCPESEGSAQVPVKVLNCDSITQAKDKLLDTVYKGIPYSQRPKAEDMDLEWRQGRMARIILQDEDITTKIECDWKRVNSLAHYQVTDGSLVALVPKQVSAYNMANSFTFTRSLSRYESLLRAASSPDSLRSRAPMLTPDQEAGTKLWHLVRNHDHTDHREGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHRGSALPLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHANDFNVLSALSELYFYVTKYRQEILTSLDRDASCRKHKLRQKLEQIITLVSSSS
uniprot
proteins
function
FUNCTION: Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm. {ECO:0000269|PubMed:11683995, ECO:0000269|PubMed:18262512, ECO:0000269|PubMed:18804103, ECO:0000269|PubMed:19020035, ECO:0000269|PubMed:19717441, ECO:0000269|PubMed:20010807}.
uniprot
proteins
mass_dalton
207958
uniprot
proteins
mutagenesis
MUTAGEN 1279; /note="L->R: Strongly reduced response to semaphorin."; /evidence="ECO:0000269|PubMed:19717441"; MUTAGEN 1300; /note="Y->A: Almost abolishes response to semaphorin."; /evidence="ECO:0000269|PubMed:19717441"; MUTAGEN 1309; /note="F->A: Almost abolishes response to semaphorin."; /evidence="ECO:0000269|PubMed:19717441"; MUTAGEN 1407..1408; /note="RR->AA: Abolishes response to semaphorin."; /evidence="ECO:0000269|PubMed:19717441"; MUTAGEN 1453; /note="I->R: Abolishes response to semaphorin."; /evidence="ECO:0000269|PubMed:19717441"; MUTAGEN 1464; /note="L->G: Almost abolishes response to semaphorin."; /evidence="ECO:0000269|PubMed:19717441"; MUTAGEN 1506; /note="Q->A: Abolishes response to semaphorin."; /evidence="ECO:0000269|PubMed:19717441"; MUTAGEN 1631..1632; /note="HL->AA: Abolishes response to semaphorin."; /evidence="ECO:0000269|PubMed:19717441
uniprot
proteins
protein_family
Plexin family
uniprot
proteins
pubmed
11683995
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18262512
uniprot
proteins
pubmed
18804103
uniprot
proteins
pubmed
19020035
uniprot
proteins
pubmed
19717441
uniprot
proteins
pubmed
20010807
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8806646
uniprot
proteins
sequence_length
1872
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 1221..1241; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins