Lamtor4
entrez
66096
canonical
uniprot
Q8CF66
canonical
ensembl
ENSMUSG00000050552
resolver
ensp
ENSMUSP00000056693
resolver
enst
ENSMUST00000062067
resolver
genesymbol
Lamtor4
resolver
uniprot
B7ZN18
resolver
uniprot
Q8CEW4
resolver
uniprot
Q8CF77
resolver
uniprot_entry
LTOR4_MOUSE
resolver
uniprot_sec
B7ZN18
resolver
uniprot_sec
Q8CEW4
resolver
uniprot_sec
Q8CF77
resolver
amino_acid_sequence
MTSALTQGLERIPDQLGYLVLSEGAVLASSGDLENDEQAASAISELVSTACGFQLHHGTNIPFKRLSVVFGEHTLLVTVSGQRVFVVKRQNRGREPIDV
uniprot
proteins
function
FUNCTION: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. {ECO:0000250|UniProtKB:Q0VGL1}.
uniprot
proteins
mass_dalton
10678
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-67 by PKA inhibits Ragulator complex assembly. {ECO:0000250|UniProtKB:Q0VGL1}.
uniprot
proteins
protein_family
LAMTOR4 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
99
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:Q0VGL1}.
uniprot
proteins