Atf7ip
entrez
54343
canonical
uniprot
Q7TT18
canonical
ensembl
ENSMUSG00000030213
resolver
ensp
ENSMUSP00000032335
resolver
ensp
ENSMUSP00000302522
resolver
ensp
ENSMUSP00000302523
resolver
genesymbol
Atf7ip
resolver
genesymbol_syn
Mcaf1
resolver
uniprot
Q3TJ86
resolver
uniprot
Q3TZW1
resolver
uniprot
Q3UVK5
resolver
uniprot
Q3UYZ7
resolver
uniprot
Q80ZK7
resolver
uniprot
Q8C4A1
resolver
uniprot
Q9JK31
resolver
uniprot_entry
MCAF1_MOUSE
resolver
uniprot_sec
Q3TJ86
resolver
uniprot_sec
Q3TZW1
resolver
uniprot_sec
Q3UVK5
resolver
uniprot_sec
Q3UYZ7
resolver
uniprot_sec
Q80ZK7
resolver
uniprot_sec
Q8C4A1
resolver
uniprot_sec
Q9JK31
resolver
amino_acid_sequence
MDSVEEPQKKVFKARKTMRASDRQQLDAVHRVKGELLRADGKLLNGSHENGDLDPTSPLENTDCIQDREEVNGIDGICFQSEESTTEWKETPCMPNVAVKNKQEDLNSEALSPSITCDLSSRVTTEPGSGSPASDNPGCGTPVSDNPASDNPASDNPASDNPDSGDLAAGELATTVQATGDSACEEPPSSDPSSSDPTSSEPSSSEPTCSEPISGDPVSEEAASHDLVSGDSTCSEPVSGEPVSHEAASSEPATSEPASDEPVARVVAACELAPGESALDDCAPSGDSQSDEPPSSEDSLPRSVCSGLASGELTPGELSVEPATDTVKPSSSAVCEAGPDPDKTEPSSNNSDDCPGKSEDDEHLDQIQSKDSCDEGNKVNSNVVEKEEPLETHSAIICSDLPPENTTKIAEDPIAEPALEEEAISSSMEVDQSEKDEHKSPAEPVAAVSEDPAEEDKEDTVVDNTDSMETDEIIPILEKLAPTEDELSCFSKASLLPVETSQDLEDKMEGSFGSPSKQESSENLPKEAFLVLSDEEDLSCGKDESEAVAQSKMSTPEGEKSEKDGKAEEEERVPAEEQPPVRNEFSRRKRSKSEDMDSVESKRRRYMDEEYEAEFQVKITAKGDINQKLQKVIQWLLQEKLCALQCAVFDKTLAELKTRVEKIECNKRHKAVLTELQAKIARLTKRFGAAKDDLKKRQESPPNPPISPGKPANDTNSNNNMTYRNAGTVRQLLESKRNVSEGPPPSFQTPVNTVSSASHATSTAVVSSQPKLQTSATSGSLPAAPLLPAPSTATVVATTQVPSGTPQPTISLQPLPVILHVPVAVTSQPQLLQSHPGTLVTNQPSGNVEFISVQSQPTVSGLTKNPVSLPPLPNPTKPNIPSVPSPSSIQRNSSTTAAPLGTTLAVQAVPTAHSIVQATRTSLPTVGPSGLYSSSSSRGPIQMKIPISTFSPPSSAEQNSSATPRIVTENQTNKTVDSSINKKAADSTSQSGKASSSDSSGVIDLTMDDEESGTTQDPKKISPPSSSTVSTSQPMSRPLQPILPAPPLQPSGVPTSGPSQATIHVLPTAPTTVNVTHRPVTQVTTRLPVPRAPANHQVVYTTLPAPTTQAPLRGTVMQAPAVRQVNPQNSVTVRVPQTTTYVVNNGLTLGSAGPQLTVHHRPPQVHNEPPRPLHPAPLPEAPQPQRLPPEAASTSLPQKPHLKLARVQSQNGIVLSWSVLEVDRSCATVDSYHLYAYHEEPSATVPSQWKKIGEVKALPLPMACTLTQFVSGSKYYFAVRAKDIYGRFGPFCDPQSTDVISSSQNS
uniprot
proteins
function
FUNCTION: Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context (PubMed:10777215). Required for HUSH-mediated heterochromatin formation and gene silencing (By similarity). Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) (PubMed:14536086). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells (By similarity). {ECO:0000250|UniProtKB:Q6VMQ6, ECO:0000269|PubMed:10777215, ECO:0000269|PubMed:14536086}.
uniprot
proteins
mass_dalton
138593
uniprot
proteins
protein_family
MCAF family
uniprot
proteins
pubmed
10777215
uniprot
proteins
pubmed
14536086
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1306
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10777215}.
uniprot
proteins