Airim
entrez
194268
canonical
uniprot
Q499E6
canonical
ensembl
ENSMUSG00000044730
resolver
ensp
ENSMUSP00000154851
resolver
genesymbol
Airim
resolver
uniprot
Q148T1
resolver
uniprot
Q3TU44
resolver
uniprot
Q8BI05
resolver
uniprot_entry
AIRIM_MOUSE
resolver
uniprot_sec
Q148T1
resolver
uniprot_sec
Q3TU44
resolver
uniprot_sec
Q8BI05
resolver
amino_acid_sequence
MAHDQPLLVVQEALRKCFPVVEEQQNLWQSTLQDCSPLLSSLSNLAEQLQAAQSLRFEDVPALRPFPDLQERLRRKQLEAGDVVLDKLAERLATLLKVRNTINSHVEQVFQAYEQHAAVLDIDTVLRPSVVSPSVADMLEWLQDIDRHYGSSYLKRKYLLSSIHWGDLASIQALPKAWDQISENECQTLVSDVLVSVSFFLEEPGGCAASGDLEHHS
uniprot
proteins
function
FUNCTION: Part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity. Involved in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles. {ECO:0000250|UniProtKB:Q9NX04}.
uniprot
proteins
mass_dalton
24442
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serines by CK2 kinase. {ECO:0000250|UniProtKB:Q9NX04}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
217
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NX04}. Cytoplasm {ECO:0000250|UniProtKB:Q9NX04}.
uniprot
proteins