Ring1
entrez
19763
canonical
uniprot
O35730
canonical
ensembl
ENSMUSG00000024325
resolver
ensp
ENSMUSP00000025183
resolver
genesymbol
Ring1
resolver
genesymbol_syn
Ring1A
resolver
genesymbol_syn
Rnf1
resolver
uniprot
Q3U242
resolver
uniprot
Q3U333
resolver
uniprot
Q4FK33
resolver
uniprot
Q63ZX8
resolver
uniprot
Q921Z8
resolver
uniprot_entry
RING1_MOUSE
resolver
uniprot_sec
Q3U242
resolver
uniprot_sec
Q3U333
resolver
uniprot_sec
Q4FK33
resolver
uniprot_sec
Q63ZX8
resolver
uniprot_sec
Q921Z8
resolver
amino_acid_sequence
MTTPANAQNASKTWELSLYELHRTPQEAIMDGTEIAVSPRSLHSELMCPICLDMLKNTMTTKECLHRFCSDCIVTALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSREEYEAHQDRVLIRLSRLHNQQALSSSIEEGLRMQAMHRAQRVRRPMPGSDQTATMSGGEGEPGEGEGDGEDVSSDSAPDSAPGPAPKRPRGAGAGASSVGTGGGAAGGACGGAGSEDSGDRGGTLGGGTLGPPSPPGAPSPPEPGGEIELVFRPHPLLVEKGEYCQTRYVKTTGNATVDHLSKYLALRIALERRQQQETTEPGGPGGGASDTGGPDGGGGERGVAGGGEGPEEPALPSLEGVSEKQYTIYIAPGGGAFTTLNGSLTLELVNEKFWKVSRPLELCYAPTKDPK
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:15525528, ECO:0000269|PubMed:16710298, ECO:0000269|PubMed:9312051}.
uniprot
proteins
mass_dalton
42631
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15525528
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16359901
uniprot
proteins
pubmed
16710298
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9312051
uniprot
proteins
sequence_length
406
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250}.
uniprot
proteins