Pias3
entrez
229615
canonical
uniprot
O54714
canonical
ensembl
ENSMUSG00000028101
resolver
ensp
ENSMUSP00000069259
resolver
ensp
ENSMUSP00000102691
resolver
ensp
ENSMUSP00000102692
resolver
genesymbol
Pias3
resolver
uniprot
Q80WF8
resolver
uniprot
Q8R598
resolver
uniprot_entry
PIAS3_MOUSE
resolver
uniprot_sec
Q80WF8
resolver
uniprot_sec
Q8R598
resolver
amino_acid_sequence
MAELGELKHMVMSFRVSELQVLLGFAGRNKSGRKHELLAKALHLLKSSCAPSVQMKIKELYRRRFPRKTLGPSDLSLLSLPPGTSPVGSPGPLAPIPPTLLTPGTLLGPKREVDMHPPLPQPVHPDVTMKPLPFYEVYGELIRPTTLASTSSQRFEEAHFTFALTPQQLQQILTSREVLPGAKCDYTIQVQLRFCLCETSCPQEDYFPPNLFVKVNGKLCPLPGYLPPTKNGAEPKRPSRPINITPLARLSATVPNTIVVNWSSEFGRNYSLSVYLVRQLTAGTLLQKLRAKGIRNPDHSRALIKEKLTADPDSEVATTSLRVSLMCPLGKMRLTVPCRALTCAHLQSFDAALYLQMNEKKPTWTCPVCDKKAPYESLIIDGLFMEILNSCSDCDEIQFMEDGSWCPMKPKKEASEVCPPPGYGLDGLQYSAVQEGIQPESKKRVEVIDLTIESSSDEEDLPPTKKHCPVTSAAIPALPGSKGALTSGHQPSSVLRSPAMGTLGSDFLSSLPLHEYPPAFPLGADIQGLDLFSFLQTESQHYGPSVITSLDEQDTLGHFFQYRGTPSHFLGPLAPTLGSSHRSSTPAPPPGRVSSIVAPGSSLREGHGGPLPSGPSLTGCRSDVISLD
uniprot
proteins
ec_number
2.3.2.-
uniprot
proteins
function
FUNCTION: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Repressor of STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Repressor of MITF transcriptional activity. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation. Sumoylates CCAR2 which promotes its interaction with SIRT1 (By similarity). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (By similarity). {ECO:0000250|UniProtKB:Q9Y6X2, ECO:0000269|PubMed:11060035, ECO:0000269|PubMed:11709556, ECO:0000269|PubMed:14596924}.
uniprot
proteins
mass_dalton
68318
uniprot
proteins
mutagenesis
MUTAGEN 19..23; /note="LQVLL->AQVAA: Nuclear and cytoplasmic location."; /evidence="ECO:0000269|PubMed:14596924"; MUTAGEN 141; /note="L->A: Greatly reduced interaction with STAT3."; MUTAGEN 143; /note="R->N: Abolishes interaction with STAT3."; MUTAGEN 143; /note="R->Q: Abolishes interaction with STAT3."; MUTAGEN 242..244; /note="INI->SDS: Nuclear and cytoplasmic location."; /evidence="ECO:0000269|PubMed:14596924"; MUTAGEN 343..348; /note="CAHLQS->GADLQG: Nuclear and cytoplasmic location."; /evidence="ECO:0000269|PubMed:14596924"; MUTAGEN 343; /note="C->S: Loss of promotion of IRF1 sumoylation, as well as of autosumoylation; partial loss of suppression of IRF1 transcriptional activity."; /evidence="ECO:0000269|PubMed:12387893
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein sumoylation.
uniprot
proteins
post_translational_modification
PTM: Sumoylated. {ECO:0000269|PubMed:12387893}.
uniprot
proteins
protein_family
PIAS family
uniprot
proteins
pubmed
10854042
uniprot
proteins
pubmed
11060035
uniprot
proteins
pubmed
11117529
uniprot
proteins
pubmed
11390395
uniprot
proteins
pubmed
11709556
uniprot
proteins
pubmed
12077349
uniprot
proteins
pubmed
12208521
uniprot
proteins
pubmed
12387893
uniprot
proteins
pubmed
12855578
uniprot
proteins
pubmed
14596924
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18681895
uniprot
proteins
pubmed
9388184
uniprot
proteins
sequence_length
628
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11060035, ECO:0000269|PubMed:11709556}. Nucleus {ECO:0000269|PubMed:11060035, ECO:0000269|PubMed:11709556, ECO:0000269|PubMed:14596924}. Nucleus speckle {ECO:0000269|PubMed:12077349}. Note=Colocalizes with MITF in the nucleus (PubMed:11709556). Colocalizes with GFI1 in nuclear dots (PubMed:11060035). Colocalizes with SUMO1 in nuclear granules (PubMed:12077349). {ECO:0000269|PubMed:11060035, ECO:0000269|PubMed:11709556, ECO:0000269|PubMed:12077349}.
uniprot
proteins