TBC1D5
entrez
9779
canonical
uniprot
Q92609
canonical
ensembl
ENSG00000131374
resolver
ensp
ENSP00000253692
resolver
ensp
ENSP00000398127
resolver
ensp
ENSP00000402935
resolver
ensp
ENSP00000512418
resolver
ensp
ENSP00000577088
resolver
ensp
ENSP00000577090
resolver
ensp
ENSP00000577092
resolver
ensp
ENSP00000577093
resolver
ensp
ENSP00000577094
resolver
ensp
ENSP00000577095
resolver
ensp
ENSP00000577097
resolver
ensp
ENSP00000577100
resolver
ensp
ENSP00000577102
resolver
ensp
ENSP00000577103
resolver
ensp
ENSP00000577104
resolver
ensp
ENSP00000577107
resolver
ensp
ENSP00000577109
resolver
ensp
ENSP00000577111
resolver
ensp
ENSP00000635856
resolver
ensp
ENSP00000635858
resolver
ensp
ENSP00000635864
resolver
ensp
ENSP00000635865
resolver
ensp
ENSP00000635867
resolver
ensp
ENSP00000635873
resolver
ensp
ENSP00000646004
resolver
genesymbol
TBC1D5
resolver
genesymbol_syn
KIAA0210
resolver
hgnc
HGNC:19166
resolver
uniprot
A6NP25
resolver
uniprot
B9A6K1
resolver
uniprot
C9JP52
resolver
uniprot_entry
B9A6K1_HUMAN
resolver
uniprot_entry
TBCD5_HUMAN
resolver
uniprot_sec
A6NP25
resolver
uniprot_sec
C9JP52
resolver
amino_acid_sequence
MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWEELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIKEIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGLSLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRPVTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGGPVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNKGLSSKNISSSPSVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEEELEAQISFLQGQLNDLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQLEAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQASSETPGCTDRGNSDDFILISKDDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVFSDPLMGPASASSSNPSSSPDDDSSKDSGFTIVSPLDI
uniprot
proteins
function
FUNCTION: May act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy (PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (PubMed:24603492). {ECO:0000269|PubMed:19531583, ECO:0000269|PubMed:20923837, ECO:0000269|PubMed:22354992, ECO:0000269|PubMed:24603492, ECO:0000305|PubMed:19531583, ECO:0000305|PubMed:22354992, ECO:0000305|PubMed:24603492}.
uniprot
proteins
mass_dalton
89004
uniprot
proteins
mutagenesis
MUTAGEN 59; /note="W->A: Disrupts interaction with VPS29."; /evidence="ECO:0000269|PubMed:22354992"; MUTAGEN 169; /note="R->A: Abolishes retromer displacement from endosome membrane; no effect on interaction with VPS29; when associated with A-204."; /evidence="ECO:0000269|PubMed:20923837"; MUTAGEN 204; /note="Q->A: Abolishes retromer displacement from endosome membrane; no effect on interaction with VPS29; when associated with A-169."; /evidence="ECO:0000269|PubMed:20923837
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19531583
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20923837
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22354992
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23908376
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24603492
uniprot
proteins
pubmed
9039502
uniprot
proteins
sequence_length
795
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:20923837}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:22354992}. Note=During starvation induced autophagy is relocalized from endosomal localization to LC3-positive autophagosomes. {ECO:0000269|PubMed:22354992}.
uniprot
proteins