LAPTM4B
entrez
55353
canonical
uniprot
Q86VI4
canonical
ensembl
ENSG00000104341
resolver
ensp
ENSP00000428409
resolver
genesymbol
LAPTM4B
resolver
hgnc
HGNC:13646
resolver
uniprot
Q3ZCV5
resolver
uniprot
Q7L909
resolver
uniprot
Q86VH8
resolver
uniprot
Q9H060
resolver
uniprot_entry
LAP4B_HUMAN
resolver
uniprot_sec
Q3ZCV5
resolver
uniprot_sec
Q7L909
resolver
uniprot_sec
Q86VH8
resolver
uniprot_sec
Q9H060
resolver
amino_acid_sequence
MTSRTRVTWPSPPRPLPVPAAAAVAFGAKGTDPAEARSSRGIEEAGPRAHGRAGREPERRRSRQQRRGGLQARRSTLLKTCARARATAPGAMKMVAPWTRFYSNSCCLCCHVRTGTILLGVWYLIINAVVLLILLSALADPDQYNFSSSELGGDFEFMDDANMCIAIAISLLMILICAMATYGAYKQRAAWIIPFFCYQIFDFALNMLVAITVLIYPNSIQEYIRQLPPNFPYRDDVMSVNPTCLVLIILLFISIILTFKGYLISCVWNCYRYINGRNSSDVLVYVTSNDTTVLLPPYDDATVNGAAKEPPPPYVSA
uniprot
proteins
function
FUNCTION: Required for optimal lysosomal function (PubMed:21224396). Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed:25588945). Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed:25998567). Plays a role as negative regulator of TGFB1 production in regulatory T cells (PubMed:26126825). Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways (PubMed:26280656). {ECO:0000269|PubMed:21224396, ECO:0000269|PubMed:25588945, ECO:0000269|PubMed:25998567, ECO:0000269|PubMed:26126825, ECO:0000269|PubMed:26280656}.
uniprot
proteins
mass_dalton
35123
uniprot
proteins
mutagenesis
MUTAGEN 296; /note="P->A: Abolishes binding to NEDD4; when associated with A-312. Increases localization to cell membrane; when associated with A-312. Retains association with HGS and enhances PIP5K1C interaction; when associated with A-312. Does not affect EGFR degradation; when associated with A-312."; /evidence="ECO:0000269|PubMed:22096579, ECO:0000269|PubMed:25588945"; MUTAGEN 312; /note="P->A: Abolishes binding to NEDD4; when associated with A-296. Increases localization to cell membrane; when associated with A-296. Retains association with HGS and enhances PIP5K1C interaction; when associated with A-296. Does not affect EGFR degradation; when associated with A-296."; /evidence="ECO:0000269|PubMed:22096579, ECO:0000269|PubMed:25588945
uniprot
proteins
post_translational_modification
PTM: Undergoes proteolytic cleavage following delivery to the lysosomes. {ECO:0000269|PubMed:21224396}.; PTM: Ubiquitinated by NEDD4. {ECO:0000269|PubMed:22096579}.
uniprot
proteins
protein_family
LAPTM4/LAPTM5 transporter family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12902989
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
21224396
uniprot
proteins
pubmed
22096579
uniprot
proteins
pubmed
25588945
uniprot
proteins
pubmed
25998567
uniprot
proteins
pubmed
26126825
uniprot
proteins
pubmed
26280656
uniprot
proteins
pubmed
28479384
uniprot
proteins
sequence_length
317
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endomembrane system {ECO:0000269|PubMed:12902989}; Multi-pass membrane protein {ECO:0000269|PubMed:12902989}. Late endosome membrane {ECO:0000269|PubMed:21224396, ECO:0000269|PubMed:22096579, ECO:0000269|PubMed:25588945}. Cell membrane {ECO:0000269|PubMed:22096579}. Cell projection {ECO:0000269|PubMed:22096579}. Lysosome membrane {ECO:0000269|PubMed:21224396, ECO:0000269|PubMed:22096579}. Endosome membrane. Endosome, multivesicular body membrane {ECO:0000269|PubMed:26280656}. Endosome, multivesicular body lumen {ECO:0000269|PubMed:26280656}.
uniprot
proteins
transmembrane_region
TRANSMEM 117..137; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 163..183; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 191..211; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 244..264; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins