Klhl2
entrez
77113
canonical
uniprot
Q8JZP3
canonical
ensembl
ENSMUSG00000031605
resolver
ensp
ENSMUSP00000034017
resolver
ensp
ENSMUSP00000147262
resolver
ensp
ENSMUSP00000254479
resolver
enst
ENSMUST00000034017
resolver
enst
ENSMUST00000210166
resolver
genesymbol
Klhl2
resolver
uniprot
A0A1B0GQV2
resolver
uniprot
Q8CCU0
resolver
uniprot
Q8R3U4
resolver
uniprot_entry
A0A1B0GQV2_MOUSE
resolver
uniprot_entry
KLHL2_MOUSE
resolver
uniprot_sec
Q8CCU0
resolver
uniprot_sec
Q8R3U4
resolver
amino_acid_sequence
METPPLPPACTKQGHQKPLDSKDENPEKHCPLTVNPWHMKKAFKVMNELRSQNLLCDVTIVAEDMEIPAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLVDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRMLMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATANEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL
uniprot
proteins
function
FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, WNK1, WNK3 and WNK4, leading most often to their proteasomal degradation (PubMed:21549840). The BCR(KLHL2) complex catalyzes ubiquitination and degradation of NPTXR (PubMed:21549840). Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4 (By similarity). Plays a role in the reorganization of the actin cytoskeleton (By similarity). Promotes growth of cell projections in oligodendrocyte precursors (By similarity). {ECO:0000250|UniProtKB:O95198, ECO:0000269|PubMed:21549840}.
uniprot
proteins
mass_dalton
65983
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:21549840}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21549840
uniprot
proteins
sequence_length
593
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21549840}. Cell projection, ruffle {ECO:0000269|PubMed:21549840}. Cell projection {ECO:0000250|UniProtKB:O95198}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:F1LZF0}. Cytoplasm, cytosol {ECO:0000269|PubMed:21549840}. Note=A proportion colocalizes with the actin cytoskeleton (By similarity). When over-expressed, colocalizes with NPTXR in perinuclear aggresomes (PubMed:21549840). {ECO:0000250|UniProtKB:O95198, ECO:0000269|PubMed:21549840}.
uniprot
proteins