Nr3c2
entrez
25672
canonical
uniprot
P22199
canonical
ensembl
ENSRNOG00000034007
resolver
ensp
ENSRNOP00000045942
resolver
ensp
ENSRNOP00000081905
resolver
enst
ENSRNOT00000052018
resolver
genesymbol
Nr3c2
resolver
genesymbol_syn
Mlr
resolver
uniprot
F1M6V2
resolver
uniprot
Q63763
resolver
uniprot
Q64174
resolver
uniprot_entry
F1M6V2_RAT
resolver
uniprot_entry
MCR_RAT
resolver
uniprot_sec
Q63763
resolver
uniprot_sec
Q64174
resolver
amino_acid_sequence
METKGYHSLPEGLDMERRWSQVSQTLERSSLGPAERTTENNYMEIVNVSCVSGAIPNNSTQGSSKEKHELLPYIQQDNSRSGILPSDIKTELESKELSATVAESMGLYMDSVRDAEYTYDQQNQQGSLSPTKIYQNMEQLVKFYKENGHRSSTLSAMSRPLRSFMPDSAASMNGGALRAIVKSPIICHEKSSSVSSPLNMASSVCSPVGINSMSSSTTSFGSFPVHSPITQGTSLTCSPSVENRGSRSHSPTHASNVGSPLSSPLSSMKSPISSPPSHCSVKSPVSSPNNVPLRSSVSSPANLNNSRCSVSSPSNNTNNRSTLSSPTASTVGSIGSPISNAFSYATSGASAGAGAIQDVVPSPDTHEKGAHDVPFPKTEEVEKAISNGVTGPLNIVQYIKSEPDGAFSSSCLGGNSKISPSSPFSVPIKQESSKHSCSGASFKGNPTVNPFPFMDGSYFSFMDDKDYYSLSGILGPPVPGFDGSCEDSAFPVGIKQEPDDGSYYPEASIPSSAIVGVNSGGQSFHYRIGAQGTISLSRSPRDQSFQHLSSFPPVNTLVESWKPHGDLSSRRSDGYPVLEYIPENVSSSTLRSVSTGSSRPSKICLVCGDEASGCHYGVVTCGSCKVFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRLQKCLQAGMNLGARKSKKLGKLKGLHEEQPQQPPPPPPQSPEEGTTYIAPTKEPSVNSALVPQLTSITHALTPSPAMILENIEPETVYAGYDNSKPDTAESLLSTLNRLAAKQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMCLSSFALSWRSYKHTNSQLLYFAPDLVFNEEKMHQSAMYELCQGMRQISLQFVRLQLTFEEYSIMKVLLLLSTVPKDGLKSQAAFEEMRTNYIKELRKMVTKCPNSSGQSWQRFYQLTKLLDSMHDLVSDLLEFCFYTFRESQALKVEFPAMLVEIITDQLPKVESGNAKPLYFHRK
uniprot
proteins
function
FUNCTION: Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels.
uniprot
proteins
mass_dalton
106737
uniprot
proteins
mutagenesis
MUTAGEN 643; /note="R->D: Lowers homodimerization and decreases receptor activity."; /evidence="ECO:0000269|PubMed:8618925"; MUTAGEN 645; /note="D->R: Lowers homodimerization and decreases receptor activity."; /evidence="ECO:0000269|PubMed:8618925
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000269|PubMed:9677313}.
uniprot
proteins
protein_family
NR3 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
10687858
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2558305
uniprot
proteins
pubmed
7495694
uniprot
proteins
pubmed
7982810
uniprot
proteins
pubmed
8618925
uniprot
proteins
pubmed
9111344
uniprot
proteins
pubmed
9677313
uniprot
proteins
sequence_length
981
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane (By similarity). {ECO:0000250}.
uniprot
proteins