Ntmt1
entrez
66617
canonical
uniprot
Q8R2U4
canonical
ensembl
ENSMUSG00000026857
resolver
ensp
ENSMUSP00000035303
resolver
ensp
ENSMUSP00000220318
resolver
ensp
ENSMUSP00000220335
resolver
ensp
ENSMUSP00000358578
resolver
enst
ENSMUST00000041830
resolver
genesymbol
Ntmt1
resolver
genesymbol_syn
Mettl11a
resolver
uniprot
A2APZ4
resolver
uniprot_entry
NTM1A_MOUSE
resolver
uniprot_sec
A2APZ4
resolver
amino_acid_sequence
MTSEVIEDEKQFYSKAKTYWKQIPPTVDGMLGGYGHISNIDLNSSRKFLQRFLREGPNKTGTSCALDCGAGIGRITKRLLLPLFRVVDMVDVTEDFLAKAKTYLGEEGKRVRNYFCCGLQDFSPEPGSYDVIWIQWVIGHLTDQHLAEFLRRCKRGLRPNGIIVIKDNMAQEGVILDDVDSSVCRDLEVVRRIIRTAGLSLLAEERQENLPDEIYHVYSFALR
uniprot
proteins
ec_number
2.1.1.244
uniprot
proteins
function
FUNCTION: Distributive alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Gly/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes mono-, di- or tri-methylation of the exposed alpha-amino group of the Ala, Gly or Ser residue in the [Ala/Gly/Ser]-Pro-Lys motif and mono- or di-methylation of Pro in the Pro-Pro-Lys motif (PubMed:20668449). Some of the substrates may be primed by NTMT2-mediated monomethylation. Catalyzes the trimethylation of the N-terminal Gly in CENPA (after removal of Met-1) (By similarity). Responsible for the N-terminal methylation of KLHL31, MYL2, MYL3, RB1, RCC1, RPL23A and SET. Required during mitosis for normal bipolar spindle formation and chromosome segregation via its action on RCC1 (PubMed:20668449). {ECO:0000250|UniProtKB:Q9BV86, ECO:0000269|PubMed:20668449}.
uniprot
proteins
mass_dalton
25420
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
protein_family
NTM1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20668449
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
223
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BV86}. Note=Predominantly nuclear. {ECO:0000250|UniProtKB:Q9BV86}.
uniprot
proteins