Paxx
entrez
227622
canonical
uniprot
Q8K0Y7
canonical
ensembl
ENSMUSG00000047617
resolver
ensp
ENSMUSP00000109899
resolver
ensp
ENSMUSP00000237923
resolver
ensp
ENSMUSP00000237930
resolver
ensp
ENSMUSP00000237953
resolver
ensp
ENSMUSP00000348666
resolver
enst
ENSMUST00000114261
resolver
genesymbol
Paxx
resolver
uniprot
Q8C6V7
resolver
uniprot_entry
PAXX_MOUSE
resolver
uniprot_sec
Q8C6V7
resolver
amino_acid_sequence
MAPPLLSLPLCILPPGSGSPRLVCYCERDSGGDGDRDDFNLYVTDAAELWSTCFSPDSLARLKARFGLSGAEDIHSRFRAACQQQAVTVSLQEDRALITLSGDTPALAFDLSKVPSPEAAPRLQALTLSLAEHVCNLERRLAAAEETITSPKKNTQPAGTQFLPELDHQRGSSGPGVRRRCPGESLINPGFKSKKPAAGVDFDET
uniprot
proteins
function
FUNCTION: Non-essential DNA repair protein involved in DNA non-homologous end joining (NHEJ); participates in double-strand break (DSB) repair and V(D)J recombination (PubMed:27601299, PubMed:27601633, PubMed:27798842, PubMed:27830975, PubMed:28051062, PubMed:29077092). May act as a scaffold required for accumulation of the Ku heterodimer, composed of XRCC5/Ku80 and XRCC6/Ku70, at double-strand break sites and promote the assembly and/or stability of the NHEJ machinery (PubMed:28051062). Involved in NHEJ by promoting the ligation of blunt-ended DNA ends (By similarity). Together with NHEJ1/XLF, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends (By similarity). Constitutes a non-essential component of classical NHEJ: has a complementary but distinct function with NHEJ1/XLF in DNA repair (PubMed:27601299, PubMed:27798842, PubMed:27830975, PubMed:28051062). {ECO:0000250|UniProtKB:Q9BUH6, ECO:0000269|PubMed:27601299, ECO:0000269|PubMed:27601633, ECO:0000269|PubMed:27798842, ECO:0000269|PubMed:27830975, ECO:0000269|PubMed:28051062, ECO:0000269|PubMed:29077092}.
uniprot
proteins
mass_dalton
21977
uniprot
proteins
post_translational_modification
PTM: Phosphorylation may inhibit interaction with the DNA-bound XRCC5/Ku80 and XRCC6/Ku70 heterodimer (Ku complex). {ECO:0000250|UniProtKB:Q9BUH6}.
uniprot
proteins
protein_family
PAXX subfamily
uniprot
proteins
protein_family
XRCC4-XLF family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27601299
uniprot
proteins
pubmed
27601633
uniprot
proteins
pubmed
27798842
uniprot
proteins
pubmed
27830975
uniprot
proteins
pubmed
28051062
uniprot
proteins
pubmed
29077092
uniprot
proteins
pubmed
29511619
uniprot
proteins
pubmed
29511621
uniprot
proteins
sequence_length
205
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BUH6}. Chromosome {ECO:0000250|UniProtKB:Q9BUH6}. Note=Predominantly localizes to the nucleus. Accumulates at sites of DNA damage generated by laser microirradiation. {ECO:0000250|UniProtKB:Q9BUH6}.
uniprot
proteins