E2F3
entrez
1871
canonical
uniprot
O00716
canonical
ensembl
ENSG00000112242
resolver
ensp
ENSP00000262904
resolver
ensp
ENSP00000443418
resolver
ensp
ENSP00000609020
resolver
genesymbol
E2F3
resolver
genesymbol_syn
KIAA0075
resolver
hgnc
HGNC:3115
resolver
uniprot
Q15000
resolver
uniprot
Q68DT0
resolver
uniprot
Q9BZ44
resolver
uniprot_entry
E2F3_HUMAN
resolver
uniprot_sec
Q15000
resolver
uniprot_sec
Q68DT0
resolver
uniprot_sec
Q9BZ44
resolver
amino_acid_sequence
MRKGIQPALEQYLVTAGGGEGAAVVAAAAAASMDKRALLASPGFAAAAAAAAAPGAYIQILTTNTSTTSCSSSLQSGAVAAGPLLPSAPGAEQTAGSLLYTTPHGPSSRAGLLQQPPALGRGGSGGGGGPPAKRRLELGESGHQYLSDGLKTPKGKGRAALRSPDSPKTPKSPSEKTRYDTSLGLLTKKFIQLLSQSPDGVLDLNKAAEVLKVQKRRIYDITNVLEGIHLIKKKSKNNVQWMGCSLSEDGGMLAQCQGLSKEVTELSQEEKKLDELIQSCTLDLKLLTEDSENQRLAYVTYQDIRKISGLKDQTVIVVKAPPETRLEVPDSIESLQIHLASTQGPIEVYLCPEETETHSPMKTNNQDHNGNIPKPASKDLASTNSGHSDCSVSMGNLSPLASPANLLQQTEDQIPSNLEGPFVNLLPPLLQEDYLLSLGEEEGISDLFDAYDLEKLPLVEDFMCS
uniprot
proteins
function
FUNCTION: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F3 binds specifically to RB1 in a cell-cycle dependent manner. Inhibits adipogenesis, probably through the repression of CEBPA binding to its target gene promoters (By similarity). {ECO:0000250|UniProtKB:O35261}.
uniprot
proteins
mass_dalton
49162
uniprot
proteins
protein_family
E2F/DP family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15716352
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
7584044
uniprot
proteins
pubmed
8246996
uniprot
proteins
sequence_length
465
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins