SLC43A1
entrez
8501
canonical
uniprot
O75387
canonical
ensembl
ENSG00000149150
resolver
ensp
ENSP00000278426
resolver
ensp
ENSP00000435673
resolver
ensp
ENSP00000571439
resolver
ensp
ENSP00000571445
resolver
ensp
ENSP00000637987
resolver
genesymbol
SLC43A1
resolver
genesymbol_syn
LAT3
resolver
genesymbol_syn
PB39
resolver
genesymbol_syn
POV1
resolver
hgnc
HGNC:9225
resolver
uniprot
B3KNL1
resolver
uniprot_entry
B3KNL1_HUMAN
resolver
uniprot_entry
LAT3_HUMAN
resolver
amino_acid_sequence
MAPTLQQAYRRRWWMACTAVLENLFFSAVLLGWGSLLIILKNEGFYSSTCPAESSTNTTQDEQRRWPGCDQQDEMLNLGFTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALASRDVEALSPLIFLALSLNGFGGICLTFTSLTLPNMFGNLRSTLMALMIGSYASSAITFPGIKLIYDAGVAFVVIMFTWSGLACLIFLNCTLNWPIEAFPAPEEVNYTKKIKLSGLALDHKVTGDLFYTHVTTMGQRLSQKAPSLEDGSDAFMSPQDVRGTSENLPERSVPLRKSLCSPTFLWSLLTMGMTQLRIIFYMAAVNKMLEYLVTGGQEHETNEQQQKVAETVGFYSSVFGAMQLLCLLTCPLIGYIMDWRIKDCVDAPTQGTVLGDARDGVATKSIRPRYCKIQKLTNAISAFTLTNLLLVGFGITCLINNLHLQFVTFVLHTIVRGFFHSACGSLYAAVFPSNHFGTLTGLQSLISAVFALLQQPLFMAMVGPLKGEPFWVNLGLLLFSLLGFLLPSYLFYYRARLQQEYAANGMGPLKVLSGSEVTA
uniprot
proteins
function
FUNCTION: Uniport that mediates the transport of neutral amino acids such as L-leucine, L-isoleucine, L-valine, and L-phenylalanine (PubMed:12930836, PubMed:26305885). The transport activity is sodium ions-independent, electroneutral and mediated by a facilitated diffusion (PubMed:12930836). Mediates the efflux of 3,3'-diiodo-L-thyronine (3,3'-T2) and 3-iodo-L-tyrosine (MIT) (PubMed:26305885). {ECO:0000269|PubMed:12930836, ECO:0000269|PubMed:26305885}.
uniprot
proteins
mass_dalton
61477
uniprot
proteins
protein_family
SLC43A transporter (TC 2.A.1.44) family
uniprot
proteins
pubmed
12930836
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19443642
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26305885
uniprot
proteins
pubmed
9255310
uniprot
proteins
pubmed
9722952
uniprot
proteins
sequence_length
559
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BSM7}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:19443642}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8BSM7}; Multi-pass membrane protein {ECO:0000255}. Note=Located in the apical plasma membrane of the podocyte foot processes (PubMed:19443642). Located in the plasma membrane of liver and skeletal muscle, and in the endoplasmic reticulum and in crystalline inclusions in pancreatic acinar cells (By similarity). {ECO:0000250|UniProtKB:Q8BSM7, ECO:0000269|PubMed:19443642}.
uniprot
proteins
transmembrane_region
TRANSMEM 20..40; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 78..98; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 105..124; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 131..151; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 168..188; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 191..211; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 304..324; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 357..377; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 419..439; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 446..466; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 485..505; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 510..530; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins