Tph2
entrez
216343
canonical
uniprot
Q8CGV2
canonical
ensembl
ENSMUSG00000006764
resolver
ensp
ENSMUSP00000006949
resolver
enst
ENSMUST00000006949
resolver
genesymbol
Tph2
resolver
genesymbol_syn
Ntph
resolver
uniprot
Q0VBT4
resolver
uniprot_entry
TPH2_MOUSE
resolver
uniprot_sec
Q0VBT4
resolver
amino_acid_sequence
MQPAMMMFSSKYWARRGLSLDSAVPEDHQLLGSLTQNKAIKSEDKKSGKEPGKGDTTESSKTAVVFSLKNEVGGLVKALRLFQEKHVNMLHIESRRSRRRSSEVEIFVDCECGKTEFNELIQLLKFQTTIVTLNPPESIWTEEEDLEDVPWFPRKISELDRCSHRVLMYGTELDADHPGFKDNVYRQRRKYFVDVAMGYKYGQPIPRVEYTEEETKTWGVVFRELSKLYPTHACREYLKNLPLLTKYCGYREDNVPQLEDVSMFLKERSGFTVRPVAGYLSPRDFLAGLAYRVFHCTQYVRHGSDPLYTPEPDTCHELLGHVPLLADPKFAQFSQEIGLASLGASDEDVQKLATCYFFTIEFGLCKQEGQLRAYGAGLLSSIGELKHALSDKACVKSFDPKTTCLQECLITTFQDAYFVSDSFEEAKEKMRDFAKSITRPFSVYFNPYTQSIEILKDTRSIENVVQDLRSDLNTVCDALNKMNQYLGI
uniprot
proteins
ec_number
1.14.16.4
uniprot
proteins
function
FUNCTION: Neuron-specific enzyme that catalyzes the conversion of L-tryptophan into 5-hydroxy-L-tryptophan, the rate-limiting step in serotonin production, using Fe(2+) as cofactor and molecular oxygen and tetrahydrobiopterin (BH4) as cosubstrates (PubMed:12511643). Plays a crucial role in regulating mood, anxiety and sleep (PubMed:18665319, PubMed:19520831, PubMed:28972592). {ECO:0000269|PubMed:12511643, ECO:0000269|PubMed:18665319, ECO:0000269|PubMed:19520831, ECO:0000269|PubMed:28972592}.
uniprot
proteins
mass_dalton
55859
uniprot
proteins
pathway_participation
PATHWAY: Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2. {ECO:0000269|PubMed:12511643}.
uniprot
proteins
protein_family
Biopterin-dependent aromatic amino acid hydroxylase family
uniprot
proteins
pubmed
12511643
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18665319
uniprot
proteins
pubmed
19520831
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28972592
uniprot
proteins
pubmed
39695187
uniprot
proteins
sequence_length
488
uniprot
proteins