COMP
entrez
1311
canonical
uniprot
P49747
canonical
ensembl
ENSG00000105664
resolver
ensp
ENSP00000222271
resolver
genesymbol
COMP
resolver
hgnc
HGNC:2227
resolver
uniprot
B4DKJ3
resolver
uniprot
O14592
resolver
uniprot
Q16388
resolver
uniprot
Q16389
resolver
uniprot
Q2NL86
resolver
uniprot
Q8N4T2
resolver
uniprot_entry
COMP_HUMAN
resolver
uniprot_sec
B4DKJ3
resolver
uniprot_sec
O14592
resolver
uniprot_sec
Q16388
resolver
uniprot_sec
Q16389
resolver
uniprot_sec
Q2NL86
resolver
uniprot_sec
Q8N4T2
resolver
amino_acid_sequence
MVPDTACVLLLTLAALGASGQGQSPLGSDLGPQMLRELQETNAALQDVRELLRQQVREITFLKNTVMECDACGMQQSVRTGLPSVRPLLHCAPGFCFPGVACIQTESGARCGPCPAGFTGNGSHCTDVNECNAHPCFPRVRCINTSPGFRCEACPPGYSGPTHQGVGLAFAKANKQVCTDINECETGQHNCVPNSVCINTRGSFQCGPCQPGFVGDQASGCQRRAQRFCPDGSPSECHEHADCVLERDGSRSCVCAVGWAGNGILCGRDTDLDGFPDEKLRCPERQCRKDNCVTVPNSGQEDVDRDGIGDACDPDADGDGVPNEKDNCPLVRNPDQRNTDEDKWGDACDNCRSQKNDDQKDTDQDGRGDACDDDIDGDRIRNQADNCPRVPNSDQKDSDGDGIGDACDNCPQKSNPDQADVDHDFVGDACDSDQDQDGDGHQDSRDNCPTVPNSAQEDSDHDGQGDACDDDDDNDGVPDSRDNCRLVPNPGQEDADRDGVGDVCQDDFDADKVVDKIDVCPENAEVTLTDFRAFQTVVLDPEGDAQIDPNWVVLNQGREIVQTMNSDPGLAVGYTAFNGVDFEGTFHVNTVTDDDYAGFIFGYQDSSSFYVVMWKQMEQTYWQANPFRAVAEPGIQLKAVKSSTGPGEQLRNALWHTGDTESQVRLLWKDPRNVGWKDKKSYRWFLQHRPQVGYIRVRFYEGPELVADSNVVLDTTMRGGRLGVFCFSQENIIWANLRYRCNDTIPEDYETHQLRQA
uniprot
proteins
disease_involvement
DISEASE: Multiple epiphyseal dysplasia 1 (EDM1) [MIM:132400]: A generalized skeletal dysplasia associated with significant morbidity. Joint pain, joint deformity, waddling gait, and short stature are the main clinical signs and symptoms. Radiological examination of the skeleton shows delayed, irregular mineralization of the epiphyseal ossification centers and of the centers of the carpal and tarsal bones. Multiple epiphyseal dysplasia is broadly categorized into the more severe Fairbank and the milder Ribbing types. The Fairbank type is characterized by shortness of stature, short and stubby fingers, small epiphyses in several joints, including the knee, ankle, hand, and hip. The Ribbing type is confined predominantly to the hip joints and is characterized by hands that are normal and stature that is normal or near-normal. {ECO:0000269|PubMed:11084047, ECO:0000269|PubMed:11565064, ECO:0000269|PubMed:21922596, ECO:0000269|PubMed:7670472, ECO:0000269|PubMed:9021009, ECO:0000269|PubMed:9184241, ECO:0000269|PubMed:9452026, ECO:0000269|PubMed:9463320, ECO:0000269|PubMed:9921895}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Pseudoachondroplasia (PSACH) [MIM:177170]: A skeletal dysplasia usually manifesting in the second year of life and characterized by moderate to severe disproportionate short stature, deformity of the lower limbs, brachydactyly, ligamentous laxity, and degenerative joint disease. {ECO:0000269|PubMed:10852928, ECO:0000269|PubMed:11084047, ECO:0000269|PubMed:11746044, ECO:0000269|PubMed:11746045, ECO:0000269|PubMed:21922596, ECO:0000269|PubMed:7670471, ECO:0000269|PubMed:7670472, ECO:0000269|PubMed:9184241, ECO:0000269|PubMed:9452026, ECO:0000269|PubMed:9452063, ECO:0000269|PubMed:9463320, ECO:0000269|PubMed:9921895}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Carpal tunnel syndrome 2 (CTS2) [MIM:619161]: An autosomal dominant form of carpal tunnel syndrome, a condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis. {ECO:0000269|PubMed:32686688}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Plays a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors (PubMed:16051604, PubMed:16542502). Could play a role in the pathogenesis of osteoarthritis (PubMed:16542502). Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP) (PubMed:17993464). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity). {ECO:0000250|UniProtKB:P35444, ECO:0000269|PubMed:16051604, ECO:0000269|PubMed:16542502, ECO:0000269|PubMed:17993464}.
uniprot
proteins
mass_dalton
82860
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved by metalloproteases ADAMTS4 and ADAMTS1 with ADAMTS4 showing more potent activity. {ECO:0000269|PubMed:39672391}.
uniprot
proteins
protein_family
Thrombospondin family
uniprot
proteins
pubmed
10852928
uniprot
proteins
pubmed
11084047
uniprot
proteins
pubmed
11565064
uniprot
proteins
pubmed
11746044
uniprot
proteins
pubmed
11746045
uniprot
proteins
pubmed
12225811
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15075323
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16051604
uniprot
proteins
pubmed
16542502
uniprot
proteins
pubmed
16611630
uniprot
proteins
pubmed
17588949
uniprot
proteins
pubmed
17993464
uniprot
proteins
pubmed
19276170
uniprot
proteins
pubmed
21922596
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
32686688
uniprot
proteins
pubmed
32747625
uniprot
proteins
pubmed
39672391
uniprot
proteins
pubmed
7670471
uniprot
proteins
pubmed
7670472
uniprot
proteins
pubmed
7713493
uniprot
proteins
pubmed
9021009
uniprot
proteins
pubmed
9184241
uniprot
proteins
pubmed
9452026
uniprot
proteins
pubmed
9452063
uniprot
proteins
pubmed
9463320
uniprot
proteins
pubmed
9921895
uniprot
proteins
sequence_length
757
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:32686688}.
uniprot
proteins