Slc27a1
entrez
26457
canonical
uniprot
Q60714
canonical
ensembl
ENSMUSG00000031808
resolver
ensp
ENSMUSP00000034267
resolver
ensp
ENSMUSP00000148768
resolver
ensp
ENSMUSP00000233344
resolver
ensp
ENSMUSP00000233352
resolver
ensp
ENSMUSP00000233365
resolver
ensp
ENSMUSP00000233366
resolver
ensp
ENSMUSP00000233368
resolver
ensp
ENSMUSP00000233370
resolver
ensp
ENSMUSP00000233374
resolver
ensp
ENSMUSP00000233419
resolver
ensp
ENSMUSP00000233458
resolver
ensp
ENSMUSP00000233478
resolver
ensp
ENSMUSP00000233488
resolver
ensp
ENSMUSP00000233507
resolver
enst
ENSMUST00000034267
resolver
enst
ENSMUST00000212889
resolver
genesymbol
Slc27a1
resolver
genesymbol_syn
Fatp
resolver
genesymbol_syn
Fatp1
resolver
uniprot
Q544D7
resolver
uniprot_entry
Q544D7_MOUSE
resolver
uniprot_entry
S27A1_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by Triacsin C (PubMed:12235169). Both insulin and muscle contraction stimulate translocation to the plasma membrane in muscle, increasing fatty acid transport activity (PubMed:19527715). {ECO:0000269|PubMed:12235169, ECO:0000269|PubMed:19527715}.
uniprot
proteins
amino_acid_sequence
MRAPGAGTASVASLALLWFLGLPWTWSAAAAFCVYVGGGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRHRRAGDTIPCIFQAVARRQPERLALVDASSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYGGEMAAAVAEVSEQLGKSLLKFCSGDLGPESILPDTQLLDPMLAEAPTTPLAQAPGKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRLAVGNGLRPAIWEEFTQRFGVPQIGEFYGATECNCSIANMDGKVGSCGFNSRILTHVYPIRLVKVNEDTMEPLRDSEGLCIPCQPGEPGLLVGQINQQDPLRRFDGYVSDSATNKKIAHSVFRKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPGVEGKAGMAAIADPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRLQREGFDPRQTSDRLFFLDLKQGRYVPLDERVHARICAGDFSL
uniprot
proteins
ec_number
6.2.1.-
uniprot
proteins
ec_number
6.2.1.15
uniprot
proteins
ec_number
6.2.1.3
uniprot
proteins
function
FUNCTION: Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane (Probable) (PubMed:10471110, PubMed:11970897, PubMed:12235169, PubMed:15699031, PubMed:19527715, PubMed:24858472, PubMed:28178239, PubMed:7954810, PubMed:9671728, PubMed:9786857). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake (PubMed:10593920, PubMed:12235169, PubMed:12937175). May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation (PubMed:14991074, PubMed:15897321). Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis (PubMed:12235169). May be involved in regulation of cholesterol metabolism (PubMed:12235169). Probably involved in fatty acid transport across the blood barrier (By similarity). {ECO:0000250|UniProtKB:Q6PCB7, ECO:0000269|PubMed:10471110, ECO:0000269|PubMed:10593920, ECO:0000269|PubMed:11970897, ECO:0000269|PubMed:12235169, ECO:0000269|PubMed:12937175, ECO:0000269|PubMed:14991074, ECO:0000269|PubMed:15699031, ECO:0000269|PubMed:15897321, ECO:0000269|PubMed:19527715, ECO:0000269|PubMed:24858472, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:7954810, ECO:0000269|PubMed:9671728, ECO:0000269|PubMed:9786857, ECO:0000305|PubMed:12556534}.
uniprot
proteins
mass_dalton
71276
uniprot
proteins
mutagenesis
MUTAGEN 249..254; /note="TSGTTG->LEAAA: Abolishes very-long-chain acyl-CoA synthetase activity."; /evidence="ECO:0000269|PubMed:10593920"; MUTAGEN 250; /note="S->A: Diminishes LCFA import and decreases nucleotide binding. No effect on localization to the cell membrane."; /evidence="ECO:0000269|PubMed:10471110, ECO:0000269|PubMed:9786857"; MUTAGEN 252; /note="T->A: Diminishes LCFA import and decreases nucleotide binding. No effect on localization to the cell membrane."; /evidence="ECO:0000269|PubMed:10471110
uniprot
proteins
protein_family
ATP-dependent AMP-binding enzyme family
uniprot
proteins
pubmed
10471110
uniprot
proteins
pubmed
10593920
uniprot
proteins
pubmed
11470793
uniprot
proteins
pubmed
11970897
uniprot
proteins
pubmed
12235169
uniprot
proteins
pubmed
12533547
uniprot
proteins
pubmed
12556534
uniprot
proteins
pubmed
12937175
uniprot
proteins
pubmed
14991074
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15699031
uniprot
proteins
pubmed
15897321
uniprot
proteins
pubmed
19527715
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24858472
uniprot
proteins
pubmed
28178239
uniprot
proteins
pubmed
7954810
uniprot
proteins
pubmed
9671728
uniprot
proteins
pubmed
9765271
uniprot
proteins
pubmed
9786857
uniprot
proteins
sequence_length
646
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10471110, ECO:0000269|PubMed:10593920, ECO:0000269|PubMed:11470793, ECO:0000269|PubMed:11970897, ECO:0000269|PubMed:24858472, ECO:0000269|PubMed:28178239, ECO:0000269|PubMed:7954810, ECO:0000269|PubMed:9786857}; Single-pass membrane protein {ECO:0000269|PubMed:11470793, ECO:0000269|PubMed:7954810}. Mitochondrion outer membrane {ECO:0000269|PubMed:24858472}. Endomembrane system {ECO:0000269|PubMed:10593920, ECO:0000269|PubMed:15897321}; Single-pass membrane protein {ECO:0000269|PubMed:11470793, ECO:0000269|PubMed:7954810}. Cytoplasm {ECO:0000269|PubMed:10593920, ECO:0000269|PubMed:15897321}. Note=Plasma membrane and intracellular membranes, at least in adipocytes (PubMed:10593920, PubMed:11970897, PubMed:28178239). In adipocytes, but not myocytes, insulin via the mTORC1 signaling pathway induces a rapid translocation of SLC27A1 from intracellular compartments to the plasma membrane, paralleled by increased LCFA uptake (PubMed:11970897, PubMed:28178239). Insulin-dependent translocation from the cytoplasm to the cell membrane is regulated by EPRS1 (PubMed:11970897, PubMed:28178239). Predominantly cytoplasmic in myocytes (PubMed:15897321). {ECO:0000269|PubMed:15897321}.
uniprot
proteins
transmembrane_region
TRANSMEM 14..34; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins