Cdca7
entrez
66953
canonical
uniprot
Q9D0M2
canonical
ensembl
ENSMUSG00000055612
resolver
ensp
ENSMUSP00000099752
resolver
ensp
ENSMUSP00000207083
resolver
ensp
ENSMUSP00000207084
resolver
enst
ENSMUST00000102691
resolver
genesymbol
Cdca7
resolver
uniprot
Q3TIS1
resolver
uniprot
Q3U511
resolver
uniprot
Q6NZE5
resolver
uniprot
Q8C1A0
resolver
uniprot_entry
CDCA7_MOUSE
resolver
uniprot_sec
Q3TIS1
resolver
uniprot_sec
Q3U511
resolver
uniprot_sec
Q6NZE5
resolver
uniprot_sec
Q8C1A0
resolver
amino_acid_sequence
MEARRARQKALKVKNLKDVRYMKLISMETSSSSDDSCDSFASDNFANTRLQLNREGCRTRSQCRHSGPLRVAMKFPARNTRRAASKKAAPPKPSESSANDSHSDSEEEEEEEEEEDGMNFLEKRALNIKQNKAMLAKLMSELESFPGLFSGRHSLPGHRAKDSKSPRRRTFPGVATRRNPERRTRPLTRSRSRILGSLGALPTEEEEEEEEEEEDKYMLVRQRKSMDSYMNDDDVPRSRRPGSMTLPHIIRPVEEVTEEEIRNICSNSREKIYNRSLGSTCHQCRQKTTDTKTNCRNPDCWGIRGQFCGPCLRNRYGEEVKDALLDPNWHCPPCRGICNCSFCRQRDGRCATGVLVYLAKYHGFGNVHAYLKSLKQEFEMQA
uniprot
proteins
function
FUNCTION: Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator (By similarity). {ECO:0000250, ECO:0000269|PubMed:16580749}.; FUNCTION: Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. Also functions as a critical cofactor for the chromatin remodeler HELLS, facilitating its recruitment to specific genomic regions to maintain DNA methylation patterns and heterochromatin integrity. Recognizes hemimethylated CpG within nucleosomes where it recruits HELLS to remodel chromatin and facilitate access of de novo DNA methyltransferases to heterochromatic regions, enabling proper establishment of DNA methylation patterns (By similarity). May play a role as transcriptional regulator (PubMed:16580749). {ECO:0000250|UniProtKB:Q9BWT1, ECO:0000269|PubMed:16580749}.
uniprot
proteins
mass_dalton
43837
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-170 promotes interaction with YWHAE and YWHAZ, dissociation from MYC and sequestration in the cytoplasm. {ECO:0000250|UniProtKB:Q9BWT1}.
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15994934
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16580749
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
382
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BWT1}. Cytoplasm {ECO:0000250|UniProtKB:Q9BWT1}. Chromosome {ECO:0000250|UniProtKB:Q9BWT1}. Note=Predominantly nuclear with some expression also seen in the cytoplasm. Predominantly cytoplasmic when phosphorylated at Thr-170. {ECO:0000250|UniProtKB:Q9BWT1}.
uniprot
proteins