Gpr83
entrez
14608
canonical
uniprot
P30731
canonical
ensembl
ENSMUSG00000031932
resolver
ensp
ENSMUSP00000034408
resolver
ensp
ENSMUSP00000111287
resolver
ensp
ENSMUSP00000260756
resolver
ensp
ENSMUSP00000260757
resolver
genesymbol
Gpr83
resolver
genesymbol_syn
Gir
resolver
genesymbol_syn
Gpr72
resolver
genesymbol_syn
Jp05
resolver
uniprot
Q542Q9
resolver
uniprot
Q544C4
resolver
uniprot_entry
GPR83_MOUSE
resolver
uniprot_sec
Q542Q9
resolver
uniprot_sec
Q544C4
resolver
amino_acid_sequence
MKVPPVLLLFLLSSVRATEQPQVVTEHPSMEAALTGPNASSHFWANYTFSDWQNFVGRRRYGAESQNPTVKALLIVAYSFTIVFSLFGNVLVCHVIFKNQRMHSATSLFIVNLAVADIMITLLNTPFTLVRFVNSTWVFGKGMCHVSRFAQYCSLHVSALTLTAIAVDRHQVIMHPLKPRISITKGVIYIAVIWVMATFFSLPHAICQKLFTFKYSEDIVRSLCLPDFPEPADLFWKYLDLATFILLYLLPLFIISVAYARVAKKLWLCNTIGDVTTEQYLALRRKKKTTVKMLVLVVVLFALCWFPLNCYVLLLSSKAIHTNNALYFAFHWFAMSSTCYNPFIYCWLNENFRVELKALLSMCQRPPKPQEDRLPSPVPSFRVAWTEKSHGRRAPLPNHHLPSSQIQSGKTDLSSVEPVVAMS
uniprot
proteins
function
FUNCTION: G protein-coupled peptide receptor (PubMed:27117253, PubMed:35605991). G protein-coupled peptide receptor. Several peptides, PEN, derived from the proSAAS precursor (PCSK1N), the procholecystokinin-derived peptide proCCK56-63, and the related proteins FAM237A and FAM237B activate GPR83 through GNAI1/G(i) and GNAS/G(s)-mediated signaling pathways. However, due to conflicting evidence about the ability of these peptides to bind to and activate the GPR83, the endogenous ligand of GPR83 still remains uncertain (PubMed:27117253, PubMed:35605991). Plays a role in food intake and body weight regulation (PubMed:23744028). May contribute to the regulation of anxiety-related behaviors (PubMed:34512237). {ECO:0000250|UniProtKB:Q9NYM4, ECO:0000269|PubMed:23744028, ECO:0000269|PubMed:27117253, ECO:0000269|PubMed:34512237, ECO:0000269|PubMed:35605991}.
uniprot
proteins
mass_dalton
48137
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1663214
uniprot
proteins
pubmed
23744028
uniprot
proteins
pubmed
27117253
uniprot
proteins
pubmed
34512237
uniprot
proteins
pubmed
35605991
uniprot
proteins
pubmed
9675427
uniprot
proteins
sequence_length
423
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27117253}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with GPR171 in the paraventricular nucleus (PubMed:27117253). Colocalizes with the ghrelin receptor GHSR1A in the hypothalamus (PubMed:23744028). {ECO:0000269|PubMed:23744028, ECO:0000269|PubMed:27117253}.
uniprot
proteins
transmembrane_region
TRANSMEM 72..92; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 108..129; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 146..167; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 187..208; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 239..260; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 294..315; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 328..348; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins