Cryaa
entrez
24273
canonical
uniprot
P24623
canonical
ensembl
ENSRNOG00000047175
resolver
ensp
ENSRNOP00000108761
resolver
ensp
ENSRNOP00000112676
resolver
enst
ENSRNOT00000071248
resolver
genesymbol
Cryaa
resolver
genesymbol_syn
Crya1
resolver
uniprot
A0ABK0M904
resolver
uniprot
A0JN13
resolver
uniprot
P02490
resolver
uniprot
P02496
resolver
uniprot
P82532
resolver
uniprot
Q61444
resolver
uniprot_entry
A0ABK0M904_RAT
resolver
uniprot_entry
A0JN13_RAT
resolver
uniprot_entry
CRYAA_RAT
resolver
uniprot_sec
P02490
resolver
uniprot_sec
P02496
resolver
uniprot_sec
P82532
resolver
uniprot_sec
Q61444
resolver
amino_acid_sequence
MDVTIQHPWFKRALGPFYPSRLFDQFFGEGLFEYDLLPFLSSTISPYYRQSLFRTVLDSGISELMTHMWFVMHQPHAGNPKNNPGKVRSDRDKFVIFLDVKHFSPEDLTVKVLEDFVEIHGKHNERQDDHGYISREFHRRYRLPSNVDQSALSCSLSADGMLTFSGPKVQSGLDAGHSERAIPVSREEKPSSAPSS
uniprot
proteins
function
FUNCTION: Contributes to the transparency and refractive index of the lens (By similarity). Acts as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions (PubMed:12118077). Required for the correct formation of lens intermediate filaments as part of a complex composed of BFSP1, BFSP2 and CRYAA (By similarity). {ECO:0000250|UniProtKB:P02489, ECO:0000269|PubMed:12118077}.; FUNCTION: [Isoform 1]: Inhibits bacterial growth in the lens. {ECO:0000269|PubMed:8875649}.
uniprot
proteins
mass_dalton
22447
uniprot
proteins
post_translational_modification
PTM: Acetylation at Lys-93 may increase chaperone activity. {ECO:0000250|UniProtKB:P02489}.; PTM: Undergoes age-dependent proteolytical cleavage at the C-terminus. Cleavage by m-calpain produces specifically alpha-crystallin A(1-162), cleavage by Capn3/Lp82 produces specifically alpha-crystallin A(1-168) which is the major truncated form during normal maturation and induced cataract formation. {ECO:0000269|PubMed:12118077, ECO:0000269|PubMed:12356833}.
uniprot
proteins
protein_family
Small heat shock protein (HSP20) family
uniprot
proteins
pubmed
12118077
uniprot
proteins
pubmed
12356833
uniprot
proteins
pubmed
1429679
uniprot
proteins
pubmed
2294971
uniprot
proteins
pubmed
6171772
uniprot
proteins
pubmed
699911
uniprot
proteins
pubmed
8875649
uniprot
proteins
sequence_length
196
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P02489}. Nucleus {ECO:0000250|UniProtKB:P02489}. Note=Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. {ECO:0000250|UniProtKB:P02489}.
uniprot
proteins