TPTE2
entrez
93492
canonical
uniprot
Q6XPS3
canonical
ensembl
ENSG00000132958
resolver
ensp
ENSP00000375098
resolver
ensp
ENSP00000382974
resolver
ensp
ENSP00000513024
resolver
ensp
ENSP00000513136
resolver
genesymbol
TPTE2
resolver
genesymbol_syn
TPIP
resolver
hgnc
HGNC:17299
resolver
uniprot
A1A4X0
resolver
uniprot
A1A4X1
resolver
uniprot
A8MX64
resolver
uniprot
B1AQ16
resolver
uniprot
B4DWZ2
resolver
uniprot
Q5VUH2
resolver
uniprot
Q8WWL4
resolver
uniprot
Q8WWL5
resolver
uniprot_entry
TPTE2_HUMAN
resolver
uniprot_sec
A1A4X0
resolver
uniprot_sec
A1A4X1
resolver
uniprot_sec
A8MX64
resolver
uniprot_sec
B1AQ16
resolver
uniprot_sec
B4DWZ2
resolver
uniprot_sec
Q5VUH2
resolver
uniprot_sec
Q8WWL4
resolver
uniprot_sec
Q8WWL5
resolver
amino_acid_sequence
MNESPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKSMLERLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGIFGVFLVLLDVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFLMDVLLRVFVEGRQQYFSDLFNILDTAIIVIPLLVDVIYIFFDIKLLRNIPRWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFWFNTSFIQNNRLCLPRNELDNPHKQKAWKIYPPEFAVEILFGEK
uniprot
proteins
ec_number
3.1.3.67
uniprot
proteins
function
FUNCTION: Acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate. {ECO:0000269|PubMed:11716755}.; FUNCTION: [Isoform 4]: Shows no phosphoinositide phosphatase activity. {ECO:0000269|PubMed:11716755}.
uniprot
proteins
mass_dalton
61112
uniprot
proteins
mutagenesis
MUTAGEN 320; /note="C->S: Loss of activity."; /evidence="ECO:0000269|PubMed:11716755
uniprot
proteins
pubmed
11716755
uniprot
proteins
pubmed
14659893
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22164291
uniprot
proteins
sequence_length
522
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 3]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11716755}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14659893}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:14659893}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000269|PubMed:11716755}.
uniprot
proteins
transmembrane_region
TRANSMEM 66..86; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 111..131; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 146..166; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins