Adam11
entrez
11488
canonical
uniprot
Q9R1V4
canonical
ensembl
ENSMUSG00000020926
resolver
ensp
ENSMUSP00000069466
resolver
ensp
ENSMUSP00000099370
resolver
enst
ENSMUST00000068150
resolver
enst
ENSMUST00000103081
resolver
genesymbol
Adam11
resolver
genesymbol_syn
Mdc
resolver
uniprot
A2AUA8
resolver
uniprot
F6WFX0
resolver
uniprot
Q3TZE2
resolver
uniprot
Q7TQG7
resolver
uniprot_entry
ADA11_MOUSE
resolver
uniprot_entry
F6WFX0_MOUSE
resolver
uniprot_entry
Q3TZE2_MOUSE
resolver
uniprot_entry
Q7TQG7_MOUSE
resolver
uniprot_sec
A2AUA8
resolver
amino_acid_sequence
MRRLRRWAIAALLLLPLLPPPGLGALGPRGALHWRSSAHVGSPESPEGSEVTEPSRLVRQSSGGEVRKPQLDTRVRQDPPRGTPVHLAQVSFVIPAFDSNFTLDLELNHHLLSSQYVERHFSREGTRQHSTGAGDHCYYHGKLRGNPQSFAALSTCQGLHGVFSDGNLTYIVEPKEIAGPWGPPQGPLPHLIYRTPLLPAPLGCREPGCLFAVPAQSALPNWPKLRRKRQVRRGHPTVHSETKYVELIVINDHQLFEQMRQSVVLTSNFAKSVVNLADVIYKEQLNTRIVLVAMETWADGDKIQVQDDLLETLARLMVYRREGLPEPSDATHLFSGRTFQSTSSGAAYVGGICSLSRGGGVNEYGNMGAMAVTLAQTLGQNLGMMWNKHRSSAGDCKCPDIWLGCIMEDTGFYLPRKFSRCSIDEYNQFLQEGGGSCLFNKPLKLLDPPECGNGFVEAGEECDCGSVQECSRAGGNCCKKCTLTHDAMCSDGLCCRRCKYEPRGVSCREAVNECDIAETCTGDSSQCPPNLHKLDGYYCDHEQGRCYGGRCKTRDRQCQALWGHAAADRFCYEKLNVEGTERGNCGRKGSGWVQCSKQDVLCGFLLCVNISGAPRLGDLGGDISSVTFYHQGKELDCRGGHVQLADGSDLSYVEDGTACGPNMLCLDHRCLPASAFNFSTCPGSGERRICSHHGVCSNEGKCICQPDWTGKDCSIHNPLPTSPPTGETERYKGPSGTNIIIGSIAGAVLVAAIVLGGTGWGFKNIRRGRSGGA
uniprot
proteins
function
FUNCTION: Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Required for localization of the potassium channel subunit proteins KCNA1/KV1.1 and KCNA2/KV1.2 at cerebellar cortex basket cell distal terminals, is thereby involved in ephaptic inhibitory synchronization of Purkinje cell firing and response to stress (PubMed:26269648). Plays a role in spatial learning and motor coordination (PubMed:16504143). Involved in the nociceptive pain response to chemical-derived stimulation (PubMed:16729981). {ECO:0000269|PubMed:16504143, ECO:0000269|PubMed:16729981, ECO:0000269|PubMed:26269648}.
uniprot
proteins
mass_dalton
84134
uniprot
proteins
post_translational_modification
PTM: The precursor is cleaved by a furin endopeptidase. {ECO:0000250}.
uniprot
proteins
pubmed
10433968
uniprot
proteins
pubmed
12088751
uniprot
proteins
pubmed
16504143
uniprot
proteins
pubmed
16729981
uniprot
proteins
pubmed
18974846
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
26269648
uniprot
proteins
sequence_length
773
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Presynaptic cell membrane {ECO:0000269|PubMed:26269648}; Single-pass type I membrane protein. Perikaryon {ECO:0000269|PubMed:26269648}. Cell projection, axon {ECO:0000269|PubMed:26269648}. Note=Localizes to basket cell terminals and pinceaux. {ECO:0000269|PubMed:26269648}.
uniprot
proteins
transmembrane_region
TRANSMEM 739..759; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins