PBXIP1
entrez
57326
canonical
uniprot
Q96AQ6
canonical
ensembl
ENSG00000163346
resolver
ensp
ENSP00000357448
resolver
ensp
ENSP00000357450
resolver
genesymbol
PBXIP1
resolver
genesymbol_syn
HPIP
resolver
hgnc
HGNC:21199
resolver
uniprot
B4E0K4
resolver
uniprot
Q5T174
resolver
uniprot
Q5T176
resolver
uniprot
Q9H8X6
resolver
uniprot
Q9HA02
resolver
uniprot
Q9HD85
resolver
uniprot_entry
B4E0K4_HUMAN
resolver
uniprot_entry
PBIP1_HUMAN
resolver
uniprot_sec
Q5T174
resolver
uniprot_sec
Q5T176
resolver
uniprot_sec
Q9H8X6
resolver
uniprot_sec
Q9HA02
resolver
uniprot_sec
Q9HD85
resolver
amino_acid_sequence
MASCPDSDNSWVLAGSESLPVETLGPASRMDPESERALQAPHSPSKTDGKELAGTMDGEGTLFQTESPQSGSILTEETEVKGTLEGDVCGVEPPGPGDTVVQGDLQETTVVTGLGPDTQDLEGQSPPQSLPSTPKAAWIREEGRCSSSDDDTDVDMEGLRRRRGREAGPPQPMVPLAVENQAGGEGAGGELGISLNMCLLGALVLLGLGVLLFSGGLSESETGPMEEVERQVLPDPEVLEAVGDRQDGLREQLQAPVPPDSVPSLQNMGLLLDKLAKENQDIRLLQAQLQAQKEELQSLMHQPKGLEEENAQLRGALQQGEAFQRALESELQQLRARLQGLEADCVRGPDGVCLSGGRGPQGDKAIREQGPREQEPELSFLKQKEQLEAEAQALRQELERQRRLLGSVQQDLERSLQDASRGDPAHAGLAELGHRLAQKLQGLENWGQDPGVSANASKAWHQKSHFQNSREWSGKEKWWDGQRDRKAEHWKHKKEESGRERKKNWGGQEDREPAGRWKEGRPRVEESGSKKEGKRQGPKEPPRKSGSFHSSGEKQKQPRWREGTKDSHDPLPSWAELLRPKYRAPQGCSGVDECARQEGLTFFGTELAPVRQQELASLLRTYLARLPWAGQLTKELPLSPAFFGEDGIFRHDRLRFRDFVDALEDSLEEVAVQQTGDDDEVDDFEDFIFSHFFGDKALKKRSGKKDKHSQSPRAAGPREGHSHSHHHHHRG
uniprot
proteins
function
FUNCTION: Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling. {ECO:0000269|PubMed:10825160, ECO:0000269|PubMed:12360403, ECO:0000269|PubMed:17043237}.
uniprot
proteins
mass_dalton
80643
uniprot
proteins
mutagenesis
MUTAGEN 615..619; /note="LASLL->AASAA: Reduces interaction with ESR1."; /evidence="ECO:0000269|PubMed:17043237
uniprot
proteins
pubmed
10825160
uniprot
proteins
pubmed
12360403
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17043237
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
731
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12360403, ECO:0000269|PubMed:17043237}. Nucleus {ECO:0000269|PubMed:10825160, ECO:0000269|PubMed:12360403}. Note=Shuttles between the nucleus and the cytosol (PubMed:12360403). Mainly localized in the cytoplasm, associated with microtubules (PubMed:10825160, PubMed:12360403). Detected in small amounts in the nucleus (PubMed:10825160).
uniprot
proteins