PSMB7
entrez
5695
canonical
uniprot
Q99436
canonical
ensembl
ENSG00000136930
resolver
ensp
ENSP00000259457
resolver
genesymbol
PSMB7
resolver
genesymbol_syn
Z
resolver
hgnc
HGNC:9544
resolver
uniprot
B4E0P1
resolver
uniprot
E9KL30
resolver
uniprot
Q5TBG6
resolver
uniprot
Q96AG8
resolver
uniprot
Q9BWA7
resolver
uniprot_entry
E9KL30_HUMAN
resolver
uniprot_entry
PSB7_HUMAN
resolver
uniprot_sec
B4E0P1
resolver
uniprot_sec
Q5TBG6
resolver
uniprot_sec
Q96AG8
resolver
uniprot_sec
Q9BWA7
resolver
amino_acid_sequence
MAAVSVYAPPVGGFSFDNCRRNAVLEADFAKRGYKLPKVRKTGTTIAGVVYKDGIVLGADTRATEGMVVADKNCSKIHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGRLPRVVTANRMLKQMLFRYQGYIGAALVLGGVDVTGPHLYSIYPHGSTDKLPYVTMGSGSLAAMAVFEDKFRPDMEEEEAKNLVSEAIAAGIFNDLGSGSNIDLCVISKNKLDFLRPYTVPNKKGTRLGRYRCEKGTTAVLTEKITPLEIEVLEETVQTMDTS
uniprot
proteins
ec_number
3.4.25.1
uniprot
proteins
function
FUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity. {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.
uniprot
proteins
mass_dalton
29965
uniprot
proteins
protein_family
Peptidase T1B family
uniprot
proteins
pubmed
12181345
uniprot
proteins
pubmed
14550573
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15244466
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17323924
uniprot
proteins
pubmed
18549262
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23495936
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25599644
uniprot
proteins
pubmed
26133119
uniprot
proteins
pubmed
27176742
uniprot
proteins
pubmed
27342858
uniprot
proteins
pubmed
27428775
uniprot
proteins
pubmed
27493187
uniprot
proteins
pubmed
34711951
uniprot
proteins
pubmed
8610016
uniprot
proteins
pubmed
8666937
uniprot
proteins
sequence_length
277
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:18549262, ECO:0000269|PubMed:34711951}. Nucleus {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:18549262, ECO:0000269|PubMed:34711951}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000269|PubMed:34711951}.
uniprot
proteins