KATNA1
entrez
84056
canonical
uniprot
Q9BW62
canonical
ensembl
ENSG00000102781
resolver
ensp
ENSP00000369989
resolver
ensp
ENSP00000369991
resolver
ensp
ENSP00000578581
resolver
ensp
ENSP00000601946
resolver
ensp
ENSP00000631680
resolver
enst
ENST00000380615
resolver
enst
ENST00000380617
resolver
enst
ENST00000908522
resolver
enst
ENST00000931887
resolver
enst
ENST00000961621
resolver
genesymbol
KATNA1
resolver
genesymbol
KATNAL1
resolver
genesymbol_syn
KATNAL1
resolver
hgnc
HGNC:28361
resolver
uniprot
A8K5X4
resolver
uniprot
B3KUK7
resolver
uniprot_entry
B3KUK7_HUMAN
resolver
uniprot_entry
KATL1_HUMAN
resolver
uniprot_sec
A8K5X4
resolver
amino_acid_sequence
MNLAEICDNAKKGREYALLGNYDSSMVYYQGVMQQIQRHCQSVRDPAIKGKWQQVRQELLEEYEQVKSIVSTLESFKIDKPPDFPVSCQDEPFRDPAVWPPPVPAEHRAPPQIRRPNREVRPLRKEMAGVGARGPVGRAHPISKSEKPSTSRDKDYRARGRDDKGRKNMQDGASDGEMPKFDGAGYDKDLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPTAKGRAELLKINLREVELDPDIQLEDIAEKIEGYSGADITNVCRDASLMAMRRRINGLSPEEIRALSKEELQMPVTKGDFELALKKIAKSVSAADLEKYEKWMVEFGSA
uniprot
proteins
ec_number
5.6.1.1
uniprot
proteins
function
FUNCTION: Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity). Has microtubule-severing activity in vitro (PubMed:26929214). {ECO:0000250|UniProtKB:Q8K0T4, ECO:0000269|PubMed:26929214}.
uniprot
proteins
mass_dalton
55392
uniprot
proteins
protein_family
A-like 1 sub-subfamily
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
protein_family
Katanin p60 subunit A1 subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22654668
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
26929214
uniprot
proteins
sequence_length
490
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03024, ECO:0000269|PubMed:22654668}. Cytoplasm {ECO:0000269|PubMed:26929214}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:26929214}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:26929214}. Note=Colocalizes with microtubules throughout the basal and adluminal compartments of Sertoli cells (By similarity). Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis (PubMed:26929214). {ECO:0000250|UniProtKB:Q8K0T4, ECO:0000269|PubMed:26929214}.
uniprot
proteins