Acrbp
entrez
500316
canonical
uniprot
Q6AY33
canonical
ensembl
ENSRNOG00000017399
resolver
ensp
ENSRNOP00000024618
resolver
genesymbol
Acrbp
resolver
uniprot_entry
ACRBP_RAT
resolver
amino_acid_sequence
MKLAASFLLMLLEVLLLPETPLSAEEALASTPGSPLSSTEYERFFALLTPTWKAETTCRLRATHGCRNPTLVQLDQYENHGLVPDGAVCSDLPYASWFESFCQFAQYRCSNHVYYAKRVRCSQPVSILSPNTLKEVESSAEVPLTSVTTPIVSRATATEHQAFQPWPERLNNNVEELLQSSLSLGGKEQQSSRKLGLEQQHKQEQIQEHKLEEAQEQEEQEEEEEEEEAKQEEGQGTEEGLDSVSRLQSDSEPKFQSKSLSSNPSFFTPRVREVESAPLMMENIQELIRSAQEMDEMNELYDDSWRSQSTGSLQQLPHTETLMVLCYSIMENTCTMTPTAKAWSYMEEEILGFGDSVCDNLGRRHTAACPLCAFCSLKLEQCHSEASVLRQQCDASHKIPFISPLLSAQSISTGNQAKIPEKGRFAGLEMYGGLSSEFWCNRLALKGCEDDRVANWLKAEFLSFQDGDLPTKICDTNYVQYPNYCSFKSQQCLLKNQNRKMSRMKCMLNEKYHVLSPAKGEEVILRWSQEFNTLTLGQFG
uniprot
proteins
function
FUNCTION: Acrosomal protein that maintains proacrosin (pro-ACR) as an enzymatically inactive zymogen in the acrosome. Involved also in the acrosome formation. {ECO:0000250|UniProtKB:Q3V140}.; FUNCTION: [Acrosin-binding protein, mature form]: Maintains pro-ACR as an enzymatically inactive zymogen in the acrosome until acrosomal exocytosis. Partially also contributes to the assembly of acrosomal proteins to form an acrosomal granule. {ECO:0000250|UniProtKB:Q3V140}.; FUNCTION: [Isoform 2]: Rodent specific isoform that participates in the formation of the acrosomal granule into the center of the acrosomal vesicle during early spermiogenesis. In the fertilization process promotes ACR release from the acrosome during acrosomal exocytosis. {ECO:0000250|UniProtKB:Q3V140}.
uniprot
proteins
mass_dalton
61080
uniprot
proteins
post_translational_modification
PTM: The N-terminus is blocked. {ECO:0000250|UniProtKB:Q29016}.; PTM: Phosphorylated on Tyr residues in capacitated sperm. {ECO:0000250|UniProtKB:Q29016}.; PTM: Synthesized as a 60-kDa precursor, the 32-kDa mature form is post-translationally produced by the removal of the N-terminal half of the precursor during sperm maturation in the testis and/or epididymis. {ECO:0000250|UniProtKB:Q29016}.
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
540
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q3V140}. Note=Colocalized with pro-ACR in the acrosomal granules of early round spermatids. {ECO:0000250|UniProtKB:Q3V140}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q3V140}. Note=Highly enriched in acrosomal granules of round spermatids, and spread over the apical end of the nucleus in elongating spermatids. Colocalized in the acrosome of epididymal sperm with pro-ACR. {ECO:0000250|UniProtKB:Q3V140}.
uniprot
proteins