Rnf5
entrez
54197
canonical
uniprot
O35445
canonical
ensembl
ENSMUSG00000015478
resolver
ensp
ENSMUSP00000015622
resolver
enst
ENSMUST00000015622
resolver
genesymbol
Rnf5
resolver
genesymbol_syn
Ng2
resolver
uniprot_entry
RNF5_MOUSE
resolver
amino_acid_sequence
MAAAEEEDGGPEGPNRERGGASATFECNICLETAREAVVSVCGHLYCWPCLHQWLETRPDRQECPVCKAGISREKVVPLYGRGSQKPQDPRLKTPPRPQGQRPAPESRGGFQPFGDAGGFHFSFGVGAFPFGFFTTVFNAHEPFRRGAGVDLGQGHPASSWQDSLFLFLAIFFFFWLLSI
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Membrane-bound E3 ubiquitin-protein ligase that mediates ubiquitination of target proteins (PubMed:23093945). May function together with E2 ubiquitin-conjugating enzymes UBE2D1/UBCH5A and UBE2D2/UBC4 (By similarity). Mediates ubiquitination of PXN/paxillin,thereby regulating cell motility and localization of PXN/paxillin (By similarity). Mediates the 'Lys-63'-linked polyubiquitination of JKAMP thereby regulating JKAMP function by decreasing its association with components of the proteasome and ERAD; the ubiquitination appears to involve E2 ubiquitin-conjugating enzyme UBE2N (By similarity). Mediates the 'Lys-48'-linked polyubiquitination of STING1 at 'Lys-150' leading to its proteasomal degradation; the ubiquitination occurs in mitochondria after viral transfection and regulates antiviral responses (By similarity). Catalyzes ubiquitination and subsequent degradation of ATG4B, thereby inhibiting autophagy (PubMed:23093945). {ECO:0000250|UniProtKB:Q99942, ECO:0000269|PubMed:23093945}.
uniprot
proteins
mass_dalton
19837
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:23093945}.
uniprot
proteins
protein_family
RNF5 family
uniprot
proteins
pubmed
12861019
uniprot
proteins
pubmed
14656967
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16166642
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23093945
uniprot
proteins
sequence_length
180
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12861019}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q99942}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q99942}; Multi-pass membrane protein {ECO:0000255}. Note=Predominantly located in the plasma membrane, with some localization occurring within cytoplasmic organelles. {ECO:0000250|UniProtKB:Q99942}.
uniprot
proteins
transmembrane_region
TRANSMEM 118..138; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 160..180; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins