SLC22A7
entrez
10864
canonical
uniprot
Q9Y694
canonical
ensembl
ENSG00000137204
resolver
ensp
ENSP00000361666
resolver
ensp
ENSP00000361670
resolver
ensp
ENSP00000545229
resolver
ensp
ENSP00000545230
resolver
ensp
ENSP00000666365
resolver
ensp
ENSP00000791206
resolver
genesymbol
SLC22A7
resolver
genesymbol_syn
NLT
resolver
genesymbol_syn
OAT2
resolver
hgnc
HGNC:10971
resolver
uniprot
B2CZX6
resolver
uniprot
Q5T046
resolver
uniprot
Q5T048
resolver
uniprot
Q5T050
resolver
uniprot
Q9H2W5
resolver
uniprot_entry
S22A7_HUMAN
resolver
uniprot_sec
B2CZX6
resolver
uniprot_sec
Q5T046
resolver
uniprot_sec
Q5T048
resolver
uniprot_sec
Q5T050
resolver
uniprot_sec
Q9H2W5
resolver
amino_acid_sequence
MGFEELLEQVGGFGPFQLRNVALLALPRVLLPLHFLLPIFLAAVPAHRCALPGAPANFSHQDVWLEAHLPREPDGTLSSCLRFAYPQALPNTTLGEERQSRGELEDEPATVPCSQGWEYDHSEFSSTIATESQWDLVCEQKGLNRAASTFFFAGVLVGAVAFGYLSDRFGRRRLLLVAYVSTLVLGLASAASVSYVMFAITRTLTGSALAGFTIIVMPLELEWLDVEHRTVAGVLSSTFWTGGVMLLALVGYLIRDWRWLLLAVTLPCAPGILSLWWVPESARWLLTQGHVKEAHRYLLHCARLNGRPVCEDSFSQEAVSKVAAGERVVRRPSYLDLFRTPRLRHISLCCVVVWFGVNFSYYGLSLDVSGLGLNVYQTQLLFGAVELPSKLLVYLSVRYAGRRLTQAGTLLGTALAFGTRLLVSSDMKSWSTVLAVMGKAFSEAAFTTAYLFTSELYPTVLRQTGMGLTALVGRLGGSLAPLAALLDGVWLSLPKLTYGGIALLAAGTALLLPETRQAQLPETIQDVERKSAPTSLQEEEMPMKQVQN
uniprot
proteins
function
FUNCTION: [Isoform 2]: Functions as a Na(+)-independent bidirectional multispecific transporter (PubMed:11327718, PubMed:18216183, PubMed:21446918, PubMed:28945155). Contributes to the renal and hepatic elimination of endogenous organic compounds from the systemic circulation into the urine and bile, respectively (PubMed:11327718, PubMed:25904762). Capable of transporting a wide range of purine and pyrimidine nucleobases, nucleosides and nucleotides, with cGMP, 2'deoxyguanosine and GMP being the preferred substrates (PubMed:11327718, PubMed:18216183, PubMed:26377792, PubMed:28945155). Functions as a pH- and chloride-independent cGMP bidirectional facilitative transporter that can regulate both intracellular and extracellular levels of cGMP and may be involved in cGMP signaling pathways (PubMed:18216183, PubMed:26377792). Mediates orotate/glutamate bidirectional exchange and most likely display a physiological role in hepatic release of glutamate into the blood (PubMed:21446918). Involved in renal secretion and possible reabsorption of creatinine (PubMed:25904762, PubMed:28945155). Able to uptake prostaglandin E2 (PGE2) and may contribute to PGE2 renal excretion (Probable). Also transports alpha-ketoglutarate and urate (PubMed:11327718, PubMed:26377792). Apart from the orotate/glutamate exchange, the counterions for the uptake of other SLC22A7/OAT2 substrates remain to be identified (PubMed:26377792). {ECO:0000269|PubMed:11327718, ECO:0000269|PubMed:18216183, ECO:0000269|PubMed:21446918, ECO:0000269|PubMed:25904762, ECO:0000269|PubMed:26377792, ECO:0000269|PubMed:28945155, ECO:0000305|PubMed:11907186}.; FUNCTION: [Isoform 1]: Non functional transporter. {ECO:0000269|PubMed:18216183, ECO:0000269|PubMed:26500550}.; FUNCTION: [Isoform 3]: Involved in the uptake of prostaglandin F2-alpha (PGF2-alpha). {ECO:0000269|PubMed:12023506}.
uniprot
proteins
mass_dalton
60026
uniprot
proteins
mutagenesis
MUTAGEN Q9Y694-2:441; /note="E->Q: Loss of glutamate transport activity; strong decrease in orotate transport activity."; /evidence="ECO:0000269|PubMed:21446918
uniprot
proteins
protein_family
Major facilitator (TC 2.A.1) superfamily
uniprot
proteins
protein_family
Organic cation transporter (TC 2.A.1.19) family
uniprot
proteins
pubmed
11327718
uniprot
proteins
pubmed
11855680
uniprot
proteins
pubmed
11907186
uniprot
proteins
pubmed
12023506
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15901346
uniprot
proteins
pubmed
18216183
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
21446918
uniprot
proteins
pubmed
25904762
uniprot
proteins
pubmed
26377792
uniprot
proteins
pubmed
26500550
uniprot
proteins
pubmed
28945155
uniprot
proteins
sequence_length
548
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 2]: Basolateral cell membrane {ECO:0000269|PubMed:12023506, ECO:0000269|PubMed:25904762}; Multi-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:25904762}; Multi-pass membrane protein {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:18216183}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the basolateral side of the proximal tubules (PubMed:12023506, PubMed:25904762). Apical side of the renal tubule (PubMed:25904762). {ECO:0000269|PubMed:12023506, ECO:0000269|PubMed:25904762}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytosol {ECO:0000269|PubMed:18216183}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..41; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 146..166; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 180..200; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 204..224; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 234..254; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 259..279; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 346..366; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 376..397; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 404..423; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 432..452; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 466..486; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 493..513; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins