Cox17
entrez
12856
canonical
uniprot
P56394
canonical
ensembl
ENSMUSG00000046516
resolver
ensp
ENSMUSP00000054086
resolver
ensp
ENSMUSP00000113430
resolver
ensp
ENSMUSP00000159636
resolver
enst
ENSMUST00000050273
resolver
enst
ENSMUST00000120495
resolver
enst
ENSMUST00000249256
resolver
genesymbol
Cox17
resolver
genesymbol_syn
Cox17a
resolver
uniprot
Q54AC6
resolver
uniprot_entry
COX17_MOUSE
resolver
uniprot_entry
Q54AC6_MOUSE
resolver
amino_acid_sequence
MPGLAAASPAPPEAQEKKPLKPCCACPETKKARDACIIEKGEEHCGHLIEAHKECMRALGFKI
uniprot
proteins
function
FUNCTION: Copper metallochaperone involved in the assembly of cytochrome c oxidase (respiratory chain complex IV, CIV) (PubMed:12370308, PubMed:37813994). Binds two copper ions and delivers them to metallochaperones SCO1 and SCO2, which co-chaperone the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2), and to metallochaperone COX11 which relays the copper to the Cu(B) site on the cytochrome c oxidase subunit I (MT-CO1/COX1) (By similarity). {ECO:0000250|UniProtKB:Q14061, ECO:0000269|PubMed:12370308, ECO:0000269|PubMed:37813994}.
uniprot
proteins
mass_dalton
6784
uniprot
proteins
mutagenesis
MUTAGEN 18; /note="K->Q: Mimics acetylation, leading to increased assembly of the mitochondrial respiratory chain complex IV (CIV); when associated with Q-30."; /evidence="ECO:0000269|PubMed:37813994"; MUTAGEN 18; /note="K->R: Abolished acetylation by KAT8, leading to decreased assembly of the mitochondrial respiratory chain complex IV (CIV); when associated with R-30."; /evidence="ECO:0000269|PubMed:37813994"; MUTAGEN 23..24; /note="CC->AA: Significant reduction of copper binding."; /evidence="ECO:0000269|PubMed:37813994"; MUTAGEN 23; /note="C->G: Significant reduction of copper binding; when associated with G-24 and G-26."; /evidence="ECO:0000269|PubMed:12370308"; MUTAGEN 24; /note="C->G: Significant reduction of copper binding; when associated with G-23 and G-26."; /evidence="ECO:0000269|PubMed:12370308"; MUTAGEN 26; /note="C->G: Significant reduction of copper binding; when associated with G-23 and G-24."; /evidence="ECO:0000269|PubMed:12370308"; MUTAGEN 30; /note="K->Q: Mimics acetylation, leading to increased assembly of the mitochondrial respiratory chain complex IV (CIV); when associated with Q-18."; /evidence="ECO:0000269|PubMed:37813994"; MUTAGEN 30; /note="K->R: Abolished acetylation by KAT8, leading to decreased assembly of the mitochondrial respiratory chain complex IV (CIV); when associated with R-18."; /evidence="ECO:0000269|PubMed:37813994
uniprot
proteins
post_translational_modification
PTM: Acetylation by KAT8 promotes assembly of the mitochondrial respiratory chain complex IV (CIV). {ECO:0000269|PubMed:37813994}.
uniprot
proteins
protein_family
COX17 family
uniprot
proteins
pubmed
12370308
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
37813994
uniprot
proteins
sequence_length
63
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000269|PubMed:37813994}. Cytoplasm {ECO:0000250|UniProtKB:Q14061}.
uniprot
proteins