NME2
entrez
4831
canonical
uniprot
P22392
canonical
ensembl
ENSG00000011052
resolver
ensembl
ENSG00000243678
resolver
ensp
ENSP00000376880
resolver
ensp
ENSP00000376886
resolver
ensp
ENSP00000421064
resolver
ensp
ENSP00000426901
resolver
ensp
ENSP00000426976
resolver
enst
ENST00000393183
resolver
genesymbol
NME2
resolver
genesymbol_syn
HEL-S-155an
resolver
genesymbol_syn
NDK2
resolver
genesymbol_syn
NM23B
resolver
hgnc
HGNC:7850
resolver
uniprot
A8MWA3
resolver
uniprot
F6XY72
resolver
uniprot
Q1WM23
resolver
uniprot
Q6FHN3
resolver
uniprot
Q6LCT6
resolver
uniprot_entry
F6XY72_HUMAN
resolver
uniprot_entry
NDKB_HUMAN
resolver
uniprot_entry
Q6FHN3_HUMAN
resolver
uniprot_sec
A8MWA3
resolver
uniprot_sec
Q1WM23
resolver
uniprot_sec
Q6LCT6
resolver
amino_acid_sequence
MANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELVDYKSCAHDWVYE
uniprot
proteins
ec_number
2.7.13.3
uniprot
proteins
ec_number
2.7.4.6
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside diphosphate via a ping-pong mechanism involving a phosphohistidine intermediate, therefore contributing to the nucleoside triphosphate homeostasis (PubMed:11121025, PubMed:16313181, PubMed:1851158, PubMed:25679041). Also functions as a histidine protein kinase by transferring the phosphoryl group from the phosphohistidine intermediate to a histidine residue in target proteins (PubMed:17157250, PubMed:20946858). Phosphorylates the GNB1 subunit of heterotrimeric G proteins at 'His-266', generating a high-energy phosphate group that promotes GTP formation and enables receptor-independent activation of heterotrimeric G proteins (By similarity). Also phosphorylates KCNN4 at 'His-358', leading to activation of its intermediate conductance calcium-activated potassium channel activity, Ca(2+) influx, and subsequent activation of B and T cells (PubMed:17157250). Additionally involved in transcriptional regulation through direct DNA binding and chromatin remodeling (PubMed:11121025, PubMed:11694515, PubMed:19033359, PubMed:19435876, PubMed:25679041, PubMed:8392752). In this context, functions as a single-stranded DNA binding protein that binds and stabilizes the G-quadruplex (G4) structures within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter, facilitating recruitment of additional single-strand DNA binding proteins and activation of MYC transcription (PubMed:19033359, PubMed:19435876, PubMed:25679041, PubMed:8392752). G4 DNA-binding activity is independent of its nucleoside diphosphate kinase function and recognizes both folded and unfolded G4 structures (PubMed:25679041). With NME1, may regulate acetyl-CoA (AcCoA) usage between histone acetylation and fatty acid synthesis by targeting AcCoA release at ATP-rich, HAT-associated chromatin regions (By similarity). Also negatively regulates Rho activity by interacting with AKAP13/LBC (PubMed:15249197). {ECO:0000250|UniProtKB:Q01768, ECO:0000250|UniProtKB:Q3T0Q4, ECO:0000269|PubMed:11121025, ECO:0000269|PubMed:11694515, ECO:0000269|PubMed:15249197, ECO:0000269|PubMed:16313181, ECO:0000269|PubMed:17157250, ECO:0000269|PubMed:1851158, ECO:0000269|PubMed:19033359, ECO:0000269|PubMed:19435876, ECO:0000269|PubMed:20946858, ECO:0000269|PubMed:25679041, ECO:0000269|PubMed:8392752}.
uniprot
proteins
mass_dalton
17298
uniprot
proteins
mutagenesis
MUTAGEN 88; /note="R->A: Decreased single-stranded DNA-binding and nucleotide-binding activity. No effect on 3D-structure."; /evidence="ECO:0000269|PubMed:19435876"; MUTAGEN 118; /note="H->N: Loss of histidine kinase activity."; /evidence="ECO:0000269|PubMed:17157250
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. {ECO:0000269|PubMed:16313181, ECO:0000269|PubMed:20946858}.
uniprot
proteins
protein_family
NDK family
uniprot
proteins
pubmed
11121025
uniprot
proteins
pubmed
11694515
uniprot
proteins
pubmed
11919189
uniprot
proteins
pubmed
15249197
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16313181
uniprot
proteins
pubmed
16442775
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17157250
uniprot
proteins
pubmed
17532299
uniprot
proteins
pubmed
1851158
uniprot
proteins
pubmed
19033359
uniprot
proteins
pubmed
19435876
uniprot
proteins
pubmed
1988104
uniprot
proteins
pubmed
20946858
uniprot
proteins
pubmed
25679041
uniprot
proteins
pubmed
39190717
uniprot
proteins
pubmed
7488060
uniprot
proteins
pubmed
7658474
uniprot
proteins
pubmed
8392752
uniprot
proteins
pubmed
8747457
uniprot
proteins
pubmed
9488696
uniprot
proteins
sequence_length
152
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17532299}. Nucleus {ECO:0000305|PubMed:19033359, ECO:0000305|PubMed:19435876, ECO:0000305|PubMed:25679041, ECO:0000305|PubMed:8392752}. Cell projection, lamellipodium {ECO:0000269|PubMed:11919189}. Cell projection, ruffle {ECO:0000269|PubMed:11919189}. Note=Colocalizes with ITGB1 and ITGB1BP1 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen but not on vitronectin or laminin substrates. {ECO:0000269|PubMed:11919189}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:16442775}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16442775}. Nucleus {ECO:0000269|PubMed:16442775}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:16442775}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16442775}. Nucleus {ECO:0000269|PubMed:16442775}.
uniprot
proteins