DMC1
entrez
11144
canonical
uniprot
Q14565
canonical
ensembl
ENSG00000100206
resolver
ensp
ENSP00000216024
resolver
ensp
ENSP00000412703
resolver
ensp
ENSP00000569177
resolver
ensp
ENSP00000581631
resolver
ensp
ENSP00000581632
resolver
ensp
ENSP00000581633
resolver
ensp
ENSP00000581637
resolver
ensp
ENSP00000581638
resolver
ensp
ENSP00000627748
resolver
ensp
ENSP00000783790
resolver
genesymbol
DMC1
resolver
genesymbol_syn
DMC1H
resolver
genesymbol_syn
LIM15
resolver
hgnc
HGNC:2927
resolver
uniprot
A8K9A2
resolver
uniprot
B4DMW6
resolver
uniprot
Q08AI1
resolver
uniprot
Q99498
resolver
uniprot
Q9UH11
resolver
uniprot_entry
DMC1_HUMAN
resolver
uniprot_sec
A8K9A2
resolver
uniprot_sec
B4DMW6
resolver
uniprot_sec
Q08AI1
resolver
uniprot_sec
Q99498
resolver
uniprot_sec
Q9UH11
resolver
amino_acid_sequence
MKEDQVVAEEPGFQDEEESLFQDIDLLQKHGINVADIKKLKSVGICTIKGIQMTTRRALCNVKGLSEAKVDKIKEAANKLIEPGFLTAFEYSEKRKMVFHITTGSQEFDKLLGGGIESMAITEAFGEFRTGKTQLSHTLCVTAQLPGAGGYPGGKIIFIDTENTFRPDRLRDIADRFNVDHDAVLDNVLYARAYTSEHQMELLDYVAAKFHEEAGIFKLLIIDSIMALFRVDFSGRGELAERQQKLAQMLSRLQKISEEYNVAVFVTNQMTADPGATMTFQADPKKPIGGHILAHASTTRISLRKGRGELRIAKIYDSPEMPENEATFAITAGGIGDAKE
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: Homologous DNA recombinase that catalyzes strand exchange during meiotic recombination (PubMed:15164066, PubMed:21307306, PubMed:26976601). Specifically required for meiotic recombination, facilitating the search and repair of DNA using the homolog rather than the sister chromatid, and can tolerate mismatches in heteroduplex DNA, unlike the higher-fidelity RAD51 (PubMed:15164066, PubMed:26976601). {ECO:0000269|PubMed:15164066, ECO:0000269|PubMed:21307306, ECO:0000269|PubMed:26976601}.
uniprot
proteins
mass_dalton
37681
uniprot
proteins
mutagenesis
MUTAGEN 89; /note="F->A: Does not affect interaction with BRCA2."; /evidence="ECO:0000269|PubMed:38828772"; MUTAGEN 153; /note="G->R,E: Decreased interaction with BRCA2."; /evidence="ECO:0000269|PubMed:38828772"; MUTAGEN 154; /note="G->Q: Decreased interaction with BRCA2."; /evidence="ECO:0000269|PubMed:38828772"; MUTAGEN 182; /note="D->K: Does not affect interaction with BRCA2."; /evidence="ECO:0000269|PubMed:38828772"; MUTAGEN 186; /note="D->K: Does not affect interaction with BRCA2."; /evidence="ECO:0000269|PubMed:38828772"; MUTAGEN 213; /note="E->K: Decreased interaction with BRCA2."; /evidence="ECO:0000269|PubMed:38828772"; MUTAGEN 230; /note="R->A: Abolishes binding to ssDNA or dsDNA."; /evidence="ECO:0000269|PubMed:15125839"; MUTAGEN 233; /note="F->A: Abolishes binding to ssDNA."; /evidence="ECO:0000269|PubMed:15125839"; MUTAGEN 236; /note="R->A: Abolishes binding to ssDNA or dsDNA."; /evidence="ECO:0000269|PubMed:15125839"; MUTAGEN 242; /note="R->A: Abolishes binding to ssDNA or dsDNA."; /evidence="ECO:0000269|PubMed:15125839"; MUTAGEN 258; /note="E->A,Q: Decreases octamer stability."; /evidence="ECO:0000269|PubMed:15125839"; MUTAGEN 311; /note="R->A: Abolishes binding to ssDNA."; /evidence="ECO:0000269|PubMed:15125839
uniprot
proteins
protein_family
DMC1 subfamily
uniprot
proteins
protein_family
RecA family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15125839
uniprot
proteins
pubmed
15164066
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20729832
uniprot
proteins
pubmed
21307306
uniprot
proteins
pubmed
21903585
uniprot
proteins
pubmed
26976601
uniprot
proteins
pubmed
31429579
uniprot
proteins
pubmed
38828772
uniprot
proteins
pubmed
39333100
uniprot
proteins
pubmed
8590282
uniprot
proteins
pubmed
8602360
uniprot
proteins
sequence_length
340
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:15164066}. Nucleus {ECO:0000269|PubMed:31429579}. Note=Binds single-stranded DNA (ssDNA) near the break site. {ECO:0000250|UniProtKB:Q61880}.
uniprot
proteins