PACC1
entrez
55248
canonical
uniprot
Q9H813
canonical
ensembl
ENSG00000065600
resolver
ensp
ENSP00000261455
resolver
ensp
ENSP00000438863
resolver
ensp
ENSP00000561030
resolver
ensp
ENSP00000561033
resolver
ensp
ENSP00000689032
resolver
ensp
ENSP00000729706
resolver
genesymbol
PACC1
resolver
genesymbol_syn
C1orf75
resolver
genesymbol_syn
TMEM206
resolver
hgnc
HGNC:25593
resolver
uniprot
B4DHQ5
resolver
uniprot
B7Z4D6
resolver
uniprot
Q6IA87
resolver
uniprot
Q9NV85
resolver
uniprot_entry
B4DHQ5_HUMAN
resolver
uniprot_entry
PACC1_HUMAN
resolver
uniprot_sec
B7Z4D6
resolver
uniprot_sec
Q6IA87
resolver
uniprot_sec
Q9NV85
resolver
amino_acid_sequence
MIRQERSTSYQELSEELVQVVENSELADEQDKETVRVQGPGILPGLDSESASSSIRFSKACLKNVFSVLLIFIYLLLMAVAVFLVYRTITDFREKLKHPVMSVSYKEVDRYDAPGIALYPGQAQLLSCKHHYEVIPPLTSPGQPGDMNCTTQRINYTDPFSNQTVKSALIVQGPREVKKRELVFLQFRLNKSSEDFSAIDYLLFSSFQEFLQSPNRVGFMQACESAYSSWKFSGGFRTWVKMSLVKTKEEDGREAVEFRQETSVVNYIDQRPAAKKSAQLFFVVFEWKDPFIQKVQDIVTANPWNTIALLCGAFLALFKAAEFAKLSIKWMIKIRKRYLKRRGQATSHIS
uniprot
proteins
function
FUNCTION: Chloride channel gated by pH that facilitates the entry of chloride ions into cells upon exposure to extracellular acidic pH (PubMed:31023925, PubMed:31318332). Involved in acidosis-induced cell death by mediating chloride influx and subsequent cell swelling (PubMed:31023925, PubMed:31318332). {ECO:0000269|PubMed:31023925, ECO:0000269|PubMed:31318332}.
uniprot
proteins
mass_dalton
40043
uniprot
proteins
mutagenesis
MUTAGEN 307; /note="I->A: Reduced I(-) permeability."; /evidence="ECO:0000269|PubMed:31023925
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:31318332}.
uniprot
proteins
protein_family
Proton-activated chloride channel family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
31023925
uniprot
proteins
pubmed
31318332
uniprot
proteins
sequence_length
350
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:31023925, ECO:0000269|PubMed:31318332}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 65..85; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 302..318; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins