Ldlrap1
entrez
100017
canonical
uniprot
Q8C142
canonical
ensembl
ENSMUSG00000037295
resolver
ensp
ENSMUSP00000036749
resolver
ensp
ENSMUSP00000257245
resolver
enst
ENSMUST00000037828
resolver
genesymbol
Ldlrap1
resolver
genesymbol_syn
Arh
resolver
uniprot
Q3TW86
resolver
uniprot
Q6NWV6
resolver
uniprot
Q8VDQ0
resolver
uniprot_entry
ARH_MOUSE
resolver
uniprot_sec
Q3TW86
resolver
uniprot_sec
Q6NWV6
resolver
uniprot_sec
Q8VDQ0
resolver
amino_acid_sequence
MDALKSAGRALIRSPSLAKQSWAGGRHRKLPENWTDTRETLLEGMVFSLKYLGMTLVERPKGEELSAAAVKRIVATAKASGKKLQKVTLKVSPRGIILTDSLTSQLIENVSIYRISYCTADKMHDKVFAYIAQSQQNESLECHAFLCTKRKVAQAVTLTVAQAFKVAFEFWQVSKEEKEKREKANQEGGDVPGTRRDSTPSLKTLVATGNLLDLEEVAKAPLSTVSANTNNVDETPRPQVLGNNSVVWELDDGLDEAFSRLAQSRTNPQVLDTGLSAQDIHYAQCLSPTDWDKPDSSGIDQDDDVFTF
uniprot
proteins
function
FUNCTION: Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytosis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression (By similarity). {ECO:0000250|UniProtKB:D3ZAR1, ECO:0000269|PubMed:12746448, ECO:0000269|PubMed:15166224}.
uniprot
proteins
mass_dalton
33975
uniprot
proteins
pubmed
12746448
uniprot
proteins
pubmed
15166224
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
308
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15166224}.
uniprot
proteins