Ric8b
entrez
237422
canonical
uniprot
Q80XE1
canonical
ensembl
ENSMUSG00000035620
resolver
ensp
ENSMUSP00000046981
resolver
ensp
ENSMUSP00000093032
resolver
ensp
ENSMUSP00000187531
resolver
ensp
ENSMUSP00000187532
resolver
ensp
ENSMUSP00000187533
resolver
genesymbol
Ric8b
resolver
uniprot
Q58L65
resolver
uniprot_entry
RIC8B_MOUSE
resolver
uniprot_sec
Q58L65
resolver
amino_acid_sequence
MDEERALYIVRAGEAGAIERVLRDYSDKHRATFKFESADEDKRKKLCEGIFKVLVKEVPTTCQVSCLEVLRILSRDKKILVPVTTKENMQILLRLAKLHESDDSLEKVSEFPVIVESLKCLCNIVFNSQMAQQLSLELNLAAKLCNLLRKCKDRKFINDIKCFDLRLLFVLSLLHTDIRSQLRYELQGLPLLTQILESAFSIKWTDEYESAIDHNGPPLSPQETDCAIEALKALFNVTVDSWKVHKESDSHQFRVMAAVLRHCLLIVGPTEDKTEELHSNAVNLLSNVPVSCLDVLICPLTHEETAQEAATLDELPSDKTTEKDTALKNSTMVYNGMNMEAIHVLLNFMEKRIDKGSSYREGLTPVLSLLTECSRAHRNIRKFLKDQVLPPLRDVTNRPEVGSTVRNKLVRLMTHVDLGVKQIAAEFLFVLCKERVDSLLKYTGYGNAAGLLAARGLLAGGRGDNWYSEDEDTDTEEYKNAKPKEELLKPMGLKPDGTITPLEEALSQYSVIEETSSDTD
uniprot
proteins
function
FUNCTION: Chaperone that specifically binds and folds nascent G(s) G-alpha proteins (GNAS and GNAL) prior to G protein heterotrimer formation, promoting their association with the plasma membrane (PubMed:22114146, PubMed:36931277). Also acts as a guanine nucleotide exchange factor (GEF) for G(s) proteins by stimulating exchange of bound GDP for free GTP (PubMed:15829631, PubMed:16754875, PubMed:21467038, PubMed:22114146). Acts as an important component for odorant signal transduction by mediating GNAL (G(olf)-alpha) folding, thereby promoting-dependent cAMP accumulation in olfactory sensory neurons (PubMed:15829631, PubMed:16754875, PubMed:29118104). {ECO:0000269|PubMed:15829631, ECO:0000269|PubMed:16754875, ECO:0000269|PubMed:21467038, ECO:0000269|PubMed:22114146, ECO:0000269|PubMed:29118104, ECO:0000269|PubMed:36931277}.
uniprot
proteins
mass_dalton
58683
uniprot
proteins
mutagenesis
MUTAGEN 71; /note="R->E: Reduced ability to fold GNAL."; /evidence="ECO:0000269|PubMed:36931277"; MUTAGEN 75; /note="R->E: Strongly reduced ability to fold GNAL."; /evidence="ECO:0000269|PubMed:36931277"; MUTAGEN 123; /note="N->A: Strongly reduced ability to fold GNAL."; /evidence="ECO:0000269|PubMed:36931277"; MUTAGEN 126; /note="F->A: Slightly reduced ability to fold GNAL."; /evidence="ECO:0000269|PubMed:36931277"; MUTAGEN 163; /note="F->A: Does not affect ability to fold GNAL."; /evidence="ECO:0000269|PubMed:36931277"; MUTAGEN 166; /note="R->A: Reduced ability to fold GNAL."; /evidence="ECO:0000269|PubMed:36931277"; MUTAGEN 400; /note="E->A: Reduced ability to fold GNAL."; /evidence="ECO:0000269|PubMed:36931277"; MUTAGEN 449; /note="A->W: Reduced ability to fold GNAL."; /evidence="ECO:0000269|PubMed:36931277"; MUTAGEN 453; /note="A->W: Does not affect ability to fold GNAL."; /evidence="ECO:0000269|PubMed:36931277
uniprot
proteins
protein_family
Synembryn family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15829631
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16754875
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21467038
uniprot
proteins
pubmed
22114146
uniprot
proteins
pubmed
29118104
uniprot
proteins
pubmed
36931277
uniprot
proteins
sequence_length
520
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cell cortex {ECO:0000269|PubMed:16754875, ECO:0000269|PubMed:22114146}. Note=Localizes to the cell cortex. {ECO:0000269|PubMed:16754875}.
uniprot
proteins