Slc22a5
entrez
20520
canonical
uniprot
Q9Z0E8
canonical
ensembl
ENSMUSG00000018900
resolver
ensp
ENSMUSP00000019044
resolver
ensp
ENSMUSP00000178796
resolver
ensp
ENSMUSP00000352189
resolver
enst
ENSMUST00000019044
resolver
genesymbol
Slc22a5
resolver
genesymbol_syn
Octn2
resolver
uniprot
Q5SX17
resolver
uniprot_entry
Q5SX17_MOUSE
resolver
uniprot_entry
S22A5_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by emetine, quinidine and verapamil. The IC(50) of emetine is 4.2 uM. Not inhibited by valproic acid. Transport of (R)-carnitine is stimulated by cholesterol in the plasma membrane. {ECO:0000250|UniProtKB:O76082}.
uniprot
proteins
amino_acid_sequence
MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFNGMSIVFLAGTPEHRCLVPHTVNLSSAWRNHSIPLETKDGRQVPQKCRRYRLATIANFSELGLEPGRDVDLEQLEQESCLDGWEYDKDVFLSTIVTEWDLVCKDDWKAPLTTSLFFVGVLMGSFISGQLSDRFGRKNVLFLTMGMQTGFSFLQVFSVNFEMFTVLFVLVGMGQISNYVAAFVLGTEILSKSIRIIFATLGVCIFYAFGFMVLPLFAYFIRDWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRIKEAEVIIRKAAKINGIVAPSTIFDPSELQDLNSTKPQLHHIYDLIRTRNIRVITIMSIILWLTISVGYFGLSLDTPNLHGDIYVNCFLLAAVEVPAYVLAWLLLQYLPRRYSISAALFLGGSVLLFMQLVPSELFYLSTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFFPESFGVPLPDTIDQMLRVKGIKQWQIQSQTRMQKDGEESPTVLKSTAF
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Slc22a5 are the cause of the juvenile visceral steatosis (JVS) phenotype. JVS is an autosomal recessive animal model of systemic carnitine deficiency.
uniprot
proteins
function
FUNCTION: Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine (PubMed:10454528, PubMed:20722056). Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3 (PubMed:10454528). May also contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (By similarity). {ECO:0000250|UniProtKB:O70594, ECO:0000269|PubMed:10454528, ECO:0000269|PubMed:20722056}.
uniprot
proteins
mass_dalton
62780
uniprot
proteins
protein_family
Major facilitator (TC 2.A.1) superfamily
uniprot
proteins
protein_family
Organic cation transporter (TC 2.A.1.19) family
uniprot
proteins
pubmed
10454528
uniprot
proteins
pubmed
11010964
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15523054
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
20722056
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9837751
uniprot
proteins
pubmed
9916797
uniprot
proteins
sequence_length
557
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:15523054, ECO:0000269|PubMed:20722056}; Multi-pass membrane protein {ECO:0000269|PubMed:15523054}. Basal cell membrane {ECO:0000250|UniProtKB:O76082}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:O76082}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O76082}. Note=Colocalizes with PDZK1 on apical membranes of kidney proximal tubules (PubMed:15523054). In intestinal cells, apical expression is induced by TNF (PubMed:20722056). {ECO:0000269|PubMed:15523054, ECO:0000269|PubMed:20722056}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..41; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 143..163; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 173..193; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 198..218; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 233..253; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 258..278; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 342..362; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 374..394; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 407..427; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 431..451; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 463..483; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 489..509; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins