CHRNA5
entrez
1138
canonical
uniprot
P30532
canonical
ensembl
ENSG00000169684
resolver
ensp
ENSP00000299565
resolver
ensp
ENSP00000453519
resolver
ensp
ENSP00000583087
resolver
ensp
ENSP00000787938
resolver
enst
ENST00000299565
resolver
enst
ENST00000559554
resolver
genesymbol
CHRNA5
resolver
genesymbol_syn
NACHRA5
resolver
hgnc
HGNC:1959
resolver
uniprot
H0YM98
resolver
uniprot
Q15824
resolver
uniprot
Q6EWN4
resolver
uniprot
Q99554
resolver
uniprot_entry
ACHA5_HUMAN
resolver
uniprot_entry
H0YM98_HUMAN
resolver
uniprot_entry
Q6EWN4_HUMAN
resolver
uniprot_sec
Q15824
resolver
uniprot_sec
Q99554
resolver
activity_regulation
ACTIVITY REGULATION: Activated by a myriad of ligands such as acetylcholine, cytisine, nicotine, choline and epibatidine. {ECO:0000269|PubMed:20881005, ECO:0000269|PubMed:8663494}.
uniprot
proteins
amino_acid_sequence
MAARGSGPRALRLLLLVQLVAGRCGLAGAAGGAQRGLSEPSSIAKHEDSLLKDLFQDYERWVRPVEHLNDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKVIRVPSDSVWTPDIVLFDNADGRFEGTSTKTVIRYNGTVTWTPPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDKRDFFDNGEWEIVSATGSKGNRTDSCCWYPYVTYSFVIKRLPLFYTLFLIIPCIGLSFLTVLVFYLPSNEGEKICLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPLVRKIFLHTLPKLLCMRSHVDRYFTQKEETESGSGPKSSRNTLEAALDSIRYITRHIMKENDVREVVEDWKFIAQVLDRMFLWTFLFVSIVGSLGLFVPVIYKWANILIPVHIGNANK
uniprot
proteins
function
FUNCTION: Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability among other activities. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits known to mediate synaptic transmission in the nervous system and the neuromuscular junction. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (PubMed:20881005, PubMed:8663494). Has an accessory rather than functional role and is only able to form functional nAChRs when co-assembled with another beta subunit (PubMed:20881005, PubMed:8663494). Participates in pentameric assemblies along with CHRNA3, CHRNA4, CHRNB2 and CHRNB4 (PubMed:20881005, PubMed:8663494). Increases receptor sensitivity to acetylcholine and nicotine when associated with CHRNA4 and CHRNB2 (PubMed:8663494). Plays a role in nicotine addiction (PubMed:20881005). {ECO:0000269|PubMed:20881005, ECO:0000269|PubMed:8663494}.
uniprot
proteins
mass_dalton
53054
uniprot
proteins
protein_family
Acetylcholine receptor (TC 1.A.9.1) subfamily
uniprot
proteins
protein_family
Alpha-5/CHRNA5 sub-subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
1542648
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18385676
uniprot
proteins
pubmed
18385720
uniprot
proteins
pubmed
18385738
uniprot
proteins
pubmed
20881005
uniprot
proteins
pubmed
27344019
uniprot
proteins
pubmed
8663494
uniprot
proteins
pubmed
8906617
uniprot
proteins
pubmed
9009220
uniprot
proteins
sequence_length
468
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Synaptic cell membrane {ECO:0000250|UniProtKB:P32297}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:P32297}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 255..275; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 282..302; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 317..337; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 430..451; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins