Smyd3
entrez
69726
canonical
uniprot
Q9CWR2
canonical
ensembl
ENSMUSG00000055067
resolver
ensp
ENSMUSP00000117410
resolver
enst
ENSMUST00000128302
resolver
genesymbol
Smyd3
resolver
genesymbol_syn
Zmynd1
resolver
uniprot
Q6P7V6
resolver
uniprot
Q8BG90
resolver
uniprot_entry
SMYD3_MOUSE
resolver
uniprot_sec
Q6P7V6
resolver
uniprot_sec
Q8BG90
resolver
activity_regulation
ACTIVITY REGULATION: Histone methyltransferase activity strongly stimulated by HSPCA. {ECO:0000250|UniProtKB:Q9H7B4}.
uniprot
proteins
amino_acid_sequence
MEALKVEKFTTANRGNGLRAVAPLRPGELLFRSDPLAYTVCKGSRGVVCDRCLLGKEKLMRCSQCRIAKYCSAKCQKKAWPDHRRECSCLKSCKPRYPPDSVRLLGRVIVKLMDEKPSESEKLYSFYDLESNISKLTEDKKEGLRQLAMTFQHFMREEIQDASQLPPSFDLFEAFAKVICNSFTICNAEMQEVGVGLYPSMSLLNHSCDPNCSIVFNGPHLLLRAVREIEAGEELTICYLDMLMTSEERRKQLRDQYCFECDCIRCQTQDKDADMLTGDEQIWKEVQESLKKIEELKAHWKWEQVLALCQAIINSNSNRLPDINIYQLKVLDCAMDACINLGMLEEALFYAMRTMEPYRIFFPGSHPVRGVQVMKVGKLQLHQGMFPQAMKNLRLAFDIMKVTHGREHSLIEDLILLLEECDANIRAS
uniprot
proteins
ec_number
2.1.1.354
uniprot
proteins
function
FUNCTION: Histone methyltransferase. Specifically methylates 'Lys-4' of histone H3, inducing di- and tri-methylation, but not monomethylation. Also methylates 'Lys-5' of histone H4. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences. {ECO:0000250|UniProtKB:Q9H7B4}.
uniprot
proteins
mass_dalton
49126
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
Histone-lysine methyltransferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
428
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H7B4}. Nucleus {ECO:0000250|UniProtKB:Q9H7B4}. Note=Mainly cytoplasmic when cells are arrested at G0/G1. Accumulates in the nucleus at S phase and G2/M. {ECO:0000250|UniProtKB:Q9H7B4}.
uniprot
proteins