Opn3
entrez
13603
canonical
uniprot
Q9WUK7
canonical
ensembl
ENSMUSG00000026525
resolver
ensp
ENSMUSP00000027809
resolver
enst
ENSMUST00000027809
resolver
genesymbol
Opn3
resolver
genesymbol_syn
Ecpn
resolver
uniprot
Q3V0X3
resolver
uniprot_entry
OPN3_MOUSE
resolver
uniprot_sec
Q3V0X3
resolver
amino_acid_sequence
MYSGNRSGDQGYWEDGAGAEGAAPAGTRSPAPLFSPTAYERLALLLGCLALLGVGGNLLVLLLYSKFPRLRTPTHLFLVNLSLGDLLVSLFGVTFTFASCLRNGWVWDAVGCAWDGFSGSLFGFVSITTLTVLAYERYIRVVHARVINFSWAWRAITYIWLYSLAWAGAPLLGWNRYILDIHGLGCTVDWRSKDANDSSFVLFLFLGCLVVPVGIIAHCYGHILYSVRMLRCVEDLQTIQVIKMLRYEKKVAKMCFLMAFVFLTCWMPYIVTRFLVVNGYGHLVTPTVSIVSYLFAKSSTVYNPVIYIFMNRKFRRSLLQLLCFRLLRCQRPAKNLPAAESEMHIRPIVMSQKDGDRPKKKVTFNSSSIIFIITSDESLSVEDSDRSSASKVDVIQVRPL
uniprot
proteins
function
FUNCTION: G protein-coupled photoreceptor that selectively activates G(i/o) proteins in response to light, thereby decreasing intracellular cAMP levels (PubMed:30284927). Activation occurs when the opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers a G protein-mediated phototransduction cascade. Mediates blue light-induced pigmentation in melanocytes by activating calcium/CAMK2 signaling, followed by phosphorylation of CREB, p38, ERK and MITF (By similarity). Required for TYR and DCT blue light-induced complex formation in melanocytes. Involved in keratinocyte differentiation in response to blue-light. Plays a role in melanocyte survival through regulation of intracellular calcium levels and subsequent BCL2/RAF1 signaling. Additionally, regulates apoptosis via cytochrome c release and subsequent activation of the caspase cascade. Responsible for ultraviolet A (UVA)-induced keratinocytes supranuclear melanin cap formation via activating calcium/CAMK2, CREB, and Akt signal transduction, and ultimately increasing DYNC1I1 and DCTN1 expression levels, thereby playing a role in the skin response to UV radiation. Required for the UVA-mediated induction of calcium and MAPK signaling resulting in the expression of MMP1, MMP2, MMP3, MMP9 and TIMP1 in dermal fibroblasts (By similarity). Also plays a role in light-mediated glucose uptake, mitochondrial respiration and fatty acid metabolism in brown adipocyte tissues (PubMed:32040503). May be involved in photorelaxation of airway smooth muscle cells, via blue light-dependent GPCR signaling pathways (PubMed:30284927). Also inhibits melanogenesis in melanocytes by specifically inhibiting MC1R-evoked cAMP signaling in a constitutive, light-independent manner (By similarity). In the paraventricular nucleus of the hypothalamus, inhibits MC4R-mediated cAMP signaling and activates KCNJ13 channel opening in a constitutive manner, thereby promoting food intake and modulating spontaneous firing of neurons (PubMed:39951488). {ECO:0000250|UniProtKB:Q9H1Y3, ECO:0000269|PubMed:30284927, ECO:0000269|PubMed:32040503, ECO:0000269|PubMed:39951488}.
uniprot
proteins
mass_dalton
44947
uniprot
proteins
mutagenesis
MUTAGEN 136..138; /note="ERY->RDR: Reduced basal glucose uptake and glucose-dependent mitochondrial respiration."; /evidence="ECO:0000269|PubMed:32040503
uniprot
proteins
post_translational_modification
PTM: Contains one retinal chromophore covalently bound to a lysine residue via a Schiff base. Upon light absorption, the bound 11-cis-retinal isomerizes to all-trans-retinal. {ECO:0000250|UniProtKB:Q9H1Y3}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Opsin subfamily
uniprot
proteins
pubmed
10234000
uniprot
proteins
pubmed
12242008
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
30284927
uniprot
proteins
pubmed
32040503
uniprot
proteins
pubmed
39951488
uniprot
proteins
sequence_length
400
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9H1Y3}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q9H1Y3}.
uniprot
proteins
transmembrane_region
TRANSMEM 39..63; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 76..100; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 116..135; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 152..175; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 200..227; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 254..277; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 286..310; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins