Fbxo44
entrez
230903
canonical
uniprot
Q8BK26
canonical
ensembl
ENSMUSG00000029001
resolver
ensp
ENSMUSP00000054022
resolver
ensp
ENSMUSP00000101330
resolver
ensp
ENSMUSP00000126551
resolver
ensp
ENSMUSP00000238012
resolver
ensp
ENSMUSP00000238043
resolver
ensp
ENSMUSP00000238059
resolver
ensp
ENSMUSP00000238069
resolver
ensp
ENSMUSP00000238070
resolver
ensp
ENSMUSP00000332544
resolver
ensp
ENSMUSP00000364926
resolver
ensp
ENSMUSP00000364928
resolver
enst
ENSMUST00000057907
resolver
enst
ENSMUST00000105705
resolver
enst
ENSMUST00000167160
resolver
genesymbol
Fbxo44
resolver
genesymbol_syn
Fbxo6a
resolver
uniprot
A2A7H5
resolver
uniprot
A2A7H6
resolver
uniprot
Q8K128
resolver
uniprot_entry
A2A7H5_MOUSE
resolver
uniprot_entry
A2A7H6_MOUSE
resolver
uniprot_entry
FBX44_MOUSE
resolver
uniprot_sec
Q8K128
resolver
amino_acid_sequence
MAVGNINELPENILLELFIHIPARQLLLRCRPVCSLWRDLIDLVTLWKRKCLQEGFITEDWDQPVADWKIFYFLRSLQRNLLHNPCAEEGFEFWSLDVNGGDEWKVEDLSKDQRKEFPNDQVKKYFVTSYYTCLKSQVVDLKAEGYWEELMDTTRPDIEVKDWFAARPDCGSKYQLCVQLLSSAHAPLGTFQPDPVMIQQKSDAKWSEVSHTFSNYPPGVRYIWFQHGGVDTHYWAGWYGPRVTNSSITIGPPLP
uniprot
proteins
function
FUNCTION: Substrate-recognition component of two distinct E3 ligase complexes, the SKP1-CUL1-FBXO44 complex and the CUL4B-DDB1-FBXO44 complex. The complex SCF(FBXO44) complex ubiquitinates and mediates BRCA1 degradation. In association with cullin 4B/CUL4B and DDB1, mediates the ubiquitination of RGS2 leading to its degradation. Additionally, regulates the pregnane X receptor/NR1I2 protein level by ubiquitination and degradation. {ECO:0000250|UniProtKB:Q9H4M3}.
uniprot
proteins
mass_dalton
29723
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18203720
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
255
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H4M3}.
uniprot
proteins