SFTPC
entrez
6440
canonical
uniprot
P11686
canonical
ensembl
ENSG00000168484
resolver
ensp
ENSP00000316152
resolver
ensp
ENSP00000429552
resolver
ensp
ENSP00000429619
resolver
ensp
ENSP00000430410
resolver
ensp
ENSP00000505152
resolver
ensp
ENSP00000620376
resolver
ensp
ENSP00000696799
resolver
ensp
ENSP00000696802
resolver
enst
ENST00000524255
resolver
genesymbol
SFTPC
resolver
genesymbol_syn
SFTP2
resolver
hgnc
HGNC:10802
resolver
uniprot
A0A0A0MTC9
resolver
uniprot
A0A0S2Z4Q0
resolver
uniprot
A6XNE4
resolver
uniprot
B2RE00
resolver
uniprot
E5RI64
resolver
uniprot
E9PGX3
resolver
uniprot
P11687
resolver
uniprot
Q12793
resolver
uniprot
Q7Z5D0
resolver
uniprot_entry
A0A0S2Z4Q0_HUMAN
resolver
uniprot_entry
E5RI64_HUMAN
resolver
uniprot_entry
PSPC_HUMAN
resolver
uniprot_sec
A0A0A0MTC9
resolver
uniprot_sec
A6XNE4
resolver
uniprot_sec
B2RE00
resolver
uniprot_sec
E9PGX3
resolver
uniprot_sec
P11687
resolver
uniprot_sec
Q12793
resolver
uniprot_sec
Q7Z5D0
resolver
amino_acid_sequence
MDVGSKEVLMESPPDYSAAPRGRFGIPCCPVHLKRLLIVVVVVVLIVVVIVGALLMGLHMSQKHTEMVLEMSIGAPEAQQRLALSEHLVTTATFSIGSTGLVVYDYQQLLIAYKPAPGTCCYIMKIAPESIPSLEALTRKVHNFQMECSLQAKPAVPTSKLGQAEGRDAGSAPSGGDPAFLGMAVSTLCGEVPLYYI
uniprot
proteins
disease_involvement
DISEASE: Pulmonary surfactant metabolism dysfunction 2 (SMDP2) [MIM:610913]: A rare disease associated with progressive respiratory insufficiency and lung disease with a variable clinical course, due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. {ECO:0000269|PubMed:11991887, ECO:0000269|PubMed:15039969, ECO:0000269|PubMed:15293602, ECO:0000269|PubMed:15557112, ECO:0000269|PubMed:15572558, ECO:0000269|PubMed:15647591}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.
uniprot
proteins
mass_dalton
21013
uniprot
proteins
pubmed
11991887
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14735158
uniprot
proteins
pubmed
15039969
uniprot
proteins
pubmed
15293602
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15557112
uniprot
proteins
pubmed
15572558
uniprot
proteins
pubmed
15647591
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
22308375
uniprot
proteins
pubmed
2326260
uniprot
proteins
pubmed
26871637
uniprot
proteins
pubmed
2839484
uniprot
proteins
pubmed
3335510
uniprot
proteins
pubmed
3366248
uniprot
proteins
pubmed
3479771
uniprot
proteins
pubmed
8181452
uniprot
proteins
sequence_length
197
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, surface film.
uniprot
proteins