Rpusd4
entrez
315550
canonical
uniprot
Q4QQT0
canonical
ensembl
ENSRNOG00000011567
resolver
ensembl
ENSRNOG00055009160
resolver
ensembl
ENSRNOG00060011711
resolver
ensembl
ENSRNOG00065016489
resolver
ensp
ENSRNOP00000015670
resolver
ensp
ENSRNOP00055012415
resolver
ensp
ENSRNOP00060015573
resolver
ensp
ENSRNOP00065021569
resolver
enst
ENSRNOT00055015500
resolver
enst
ENSRNOT00060019827
resolver
enst
ENSRNOT00065027440
resolver
genesymbol
Rpusd4
resolver
uniprot_entry
RUSD4_RAT
resolver
amino_acid_sequence
MAAPLLGSPGLQVLSMSSRTGKLFTPSSRSFCSRATSSRPLNAQRLAEKLRAQKQEQKTKEMRVPTNPVQRRVQELVRFTQQLQRVHPNVLAKELSRRILHQDKDLVVINKPYGLPVHGGPGVQLCISDVLPILAKMLHGHKAEPLHLCHRLDKETTGVMVLAWEKDMAHQVQELFRTRQVEKKYWAITVRVPLPSAGVVDIPIMEKEVAGQQQHHKMTLRPSYRMDNGKMVKVRASRDAHVAVTQYQVLSSTPSSALVELQPVTGIKHQLRVHLAFGLDCPILGDHKYSDWNRLAPQKLSAGTLKKLGLQQSKARYIPLHLHARQLILPALGSRTEELLLACKLPHFFARSLRRLGLDMPNEDQSRSHEARHVEAR
uniprot
proteins
ec_number
5.4.99.-
uniprot
proteins
function
FUNCTION: Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates. Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome. As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA, controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation. Acts on position 39 in mitochondrial tRNA(Phe). Also catalyzes pseudouridylation of mRNAs in nucleus: acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions. Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing. {ECO:0000250|UniProtKB:Q96CM3}.
uniprot
proteins
mass_dalton
42595
uniprot
proteins
protein_family
Pseudouridine synthase RluA family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
377
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:Q96CM3}. Nucleus {ECO:0000250|UniProtKB:Q96CM3}. Cytoplasm {ECO:0000250|UniProtKB:Q96CM3}. Note=Mainly localizes to mitochondrion. Localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly. Also found in nucleus and cytoplasm. {ECO:0000250|UniProtKB:Q96CM3}.
uniprot
proteins