Sp100
entrez
20684
canonical
uniprot
O35892
canonical
ensembl
ENSMUSG00000026222
resolver
ensp
ENSMUSP00000051705
resolver
ensp
ENSMUSP00000066399
resolver
ensp
ENSMUSP00000116942
resolver
ensp
ENSMUSP00000118481
resolver
ensp
ENSMUSP00000304903
resolver
ensp
ENSMUSP00000304904
resolver
ensp
ENSMUSP00000304906
resolver
ensp
ENSMUSP00000304907
resolver
ensp
ENSMUSP00000304908
resolver
ensp
ENSMUSP00000363939
resolver
enst
ENSMUST00000054279
resolver
enst
ENSMUST00000066427
resolver
genesymbol
Sp100
resolver
uniprot
E9PY02
resolver
uniprot
E9Q4Y0
resolver
uniprot
F6SC89
resolver
uniprot
O35897
resolver
uniprot
O88392
resolver
uniprot
O88395
resolver
uniprot
Q3U876
resolver
uniprot
Q3UKD8
resolver
uniprot
Q6NTA3
resolver
uniprot
Q8BNW8
resolver
uniprot
Q8C405
resolver
uniprot_entry
E9Q4Y0_MOUSE
resolver
uniprot_entry
F6SC89_MOUSE
resolver
uniprot_entry
Q3U876_MOUSE
resolver
uniprot_entry
Q3UKD8_MOUSE
resolver
uniprot_entry
Q6NTA3_MOUSE
resolver
uniprot_entry
Q8BNW8_MOUSE
resolver
uniprot_entry
Q8C405_MOUSE
resolver
uniprot_entry
SP100_MOUSE
resolver
uniprot_sec
E9PY02
resolver
uniprot_sec
O35897
resolver
uniprot_sec
O88392
resolver
uniprot_sec
O88395
resolver
amino_acid_sequence
MEGSDGSPRMSTEQENTEMHLIECMLKHFKTQKVAISNAIRSTFPFLESLRDHEFITGKMYEDLLDSCRSLVPVDKVIYRALEELEKKFDMTVLCELFNEVNMEKYPDLNLIRRSFGCVFPNELCFQGIDGGNPNSQLSLEQGPGASYSQGSPNGSSLDLSASEGWRSNDRRNSNLMQANQTENHQLAESPGHLDSCELQVQLNNRDATPESCSLLPQNEERAVQLNYELQINPCFVQLVDVKKENSSFSLAGNQQTRARTNQNEDSEIIELSSGDSDNGENFSEATTTVPSQPAPAYSRKPPTLRRDRGGDTSDTESSIIIRRRKRTGRKKRERLGSYLIRNIKIPMKPSWKTAFLARSANPSSQRRRKRGPRIPREENADFGGAELPVVCGNAQGFLDKEKFKQGIYVRSIRGKTGRLFTPMDFEIEGNCEKAKNWRQSIRCKGWTLRELIQKGVLQDPPRKKKETPRNPRQTRRQVNAL
uniprot
proteins
function
FUNCTION: Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. May also play a role in infection by viruses through mechanisms that may involve chromatin and/or transcriptional regulation (By similarity). {ECO:0000250|UniProtKB:P23497}.
uniprot
proteins
mass_dalton
54727
uniprot
proteins
post_translational_modification
PTM: Sumoylated. Sumoylated with SUMO1. Sumoylation depends on a functional nuclear localization signal but is not necessary for nuclear import or nuclear body targeting. Sumoylation may stabilize the interaction with CBX5 (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9268632
uniprot
proteins
pubmed
9678363
uniprot
proteins
sequence_length
482
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P23497}. Nucleus, PML body {ECO:0000250|UniProtKB:P23497}. Nucleus, nuclear body {ECO:0000250|UniProtKB:P23497}. Cytoplasm {ECO:0000250|UniProtKB:P23497}. Note=Accumulates in the cytoplasm upon FAS activation. {ECO:0000250|UniProtKB:P23497}.
uniprot
proteins