Sord
entrez
20322
canonical
uniprot
Q64442
canonical
ensembl
ENSMUSG00000027227
resolver
ensp
ENSMUSP00000106180
resolver
enst
ENSMUST00000110551
resolver
genesymbol
Sord
resolver
genesymbol_syn
Sdh1
resolver
uniprot
Q569V5
resolver
uniprot
Q9CPS0
resolver
uniprot_entry
DHSO_MOUSE
resolver
uniprot_sec
Q569V5
resolver
uniprot_sec
Q9CPS0
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited in vitro by p-hydroxymercuribenzoate, EDTA, l,l0-phenanthroline and N-ethylmaleimide. {ECO:0000269|PubMed:6852349}.
uniprot
proteins
amino_acid_sequence
MAAPAKGENLSLVVHGPGDIRLENYPIPELGPNDVLLKMHSVGICGSDVHYWEHGRIGDFVVKKPMVLGHEAAGTVTKVGELVKHLKPGDRVAIEPGVPREVDEYCKIGRYNLTPTIFFCATPPDDGNLCRFYKHNADFCYKLPDSVTFEEGALIEPLSVGIYACRRGSVSLGNKVLVCGAGPVGMVTLLVAKAMGAAQVVVTDLSASRLTKAKEVGADFTIQVGKETPQEIASKVESLLGSKPEVTIECTGAESSVQTGIYATHSGGTLVIVGMGAEMVNLPLVHAAIREVDIKGVFRYCNTWPMAISMLASKTLNVKPLVTHRFPLEKAVEAFETAKKGVGLKVMIKCDPNDQNP
uniprot
proteins
ec_number
1.1.1.-
uniprot
proteins
ec_number
1.1.1.14
uniprot
proteins
ec_number
1.1.1.9
uniprot
proteins
function
FUNCTION: Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols (By similarity). Is active with D-sorbitol (D-glucitol) leading to the C2-oxidized product D-fructose (PubMed:6852349). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism (By similarity). May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility and protein tyrosine phosphorylation (PubMed:18799757). Has no activity on ethanol. Cannot use NADP(+) as the electron acceptor (PubMed:6852349). {ECO:0000250|UniProtKB:Q00796, ECO:0000269|PubMed:18799757, ECO:0000269|PubMed:6852349}.
uniprot
proteins
mass_dalton
38249
uniprot
proteins
protein_family
Zinc-containing alcohol dehydrogenase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
18799757
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
6852349
uniprot
proteins
pubmed
7601136
uniprot
proteins
sequence_length
357
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:18799757}; Peripheral membrane protein {ECO:0000269|PubMed:18799757}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:18799757}. Note=Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface.
uniprot
proteins