Polr3d
entrez
67065
canonical
uniprot
Q91WD1
canonical
ensembl
ENSMUSG00000000776
resolver
ensp
ENSMUSP00000000793
resolver
ensp
ENSMUSP00000137614
resolver
enst
ENSMUST00000000793
resolver
enst
ENSMUST00000180358
resolver
genesymbol
Polr3d
resolver
genesymbol_syn
Bn51t
resolver
uniprot
Q3U0T3
resolver
uniprot
Q9CZ02
resolver
uniprot_entry
RPC4_MOUSE
resolver
uniprot_sec
Q3U0T3
resolver
uniprot_sec
Q9CZ02
resolver
amino_acid_sequence
MSEGNAAGEPSNPGGPRPLLSGGRGLIGRRPAPPLTPGRLPSIRSRDLTLGGVKKKTFTPNIISRKIKEEPKEEVTMKKEKRERDRDRQREGHGRGRGRPEVIQSHSIFEQGPAEMMKKKGNWDKTVDMSDMGPSHIINIKKEKRETDEETKQILRMLEKDDFIDDPGLKNDTRNMPVQLPLAHSGWLFKEESEEPEAKPFSAGPKEEDMEVDVPAVKVKEEPRDEEEEAKVKAPPRAARKTPGLPKDVSVAELLRELSLMKDEELLFLQLPDTLPGQPPTQDIKPVKTEVQGEDGQMVVIKQEKDREARLAENACTLADLTEGQVGKLLIRKSGKVQLLLGKVTLDVTMGTTCSFLQELVSVGLGDSRTGEMTVLGHVKHKLVCSPDFESLLDHKHR
uniprot
proteins
function
FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Enables recruitment of Pol III at transcription initiation site and drives transcription initiation from both type 2 and type 3 DNA promoters. Required for efficient transcription termination and reinitiation (By similarity). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (By similarity). {ECO:0000250|UniProtKB:P05423, ECO:0000250|UniProtKB:P25441}.
uniprot
proteins
mass_dalton
44357
uniprot
proteins
post_translational_modification
PTM: Sumoylation on Lys-141 can serve as a signal to mark misfolded Pol III for proteasomal degradation. {ECO:0000250|UniProtKB:P05423}.
uniprot
proteins
protein_family
Eukaryotic RPC4/POLR3D RNA polymerase subunit family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
398
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins