FABP5
entrez
2171
canonical
uniprot
Q01469
canonical
ensembl
ENSG00000164687
resolver
ensp
ENSP00000297258
resolver
enst
ENST00000297258
resolver
genesymbol
FABP5
resolver
hgnc
HGNC:3560
resolver
uniprot
B2R4K0
resolver
uniprot_entry
FABP5_HUMAN
resolver
uniprot_sec
B2R4K0
resolver
amino_acid_sequence
MATVQQLEGRWRLVDSKGFDEYMKELGVGIALRKMGAMAKPDCIITCDGKNLTIKTESTLKTTQFSCTLGEKFEETTADGRKTQTVCNFTDGALVQHQEWDGKESTITRKLKDGKLVVECVMNNVTCTRIYEKVE
uniprot
proteins
function
FUNCTION: Intracellular carrier for long-chain fatty acids and related active lipids, such as endocannabinoids, that regulate the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (PubMed:21395585, PubMed:22170058). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (By similarity). May be involved in keratinocyte differentiation (PubMed:8092987). {ECO:0000250|UniProtKB:Q05816, ECO:0000269|PubMed:21395585, ECO:0000269|PubMed:22170058, ECO:0000269|PubMed:8092987}.
uniprot
proteins
mass_dalton
15164
uniprot
proteins
mutagenesis
MUTAGEN 24; /note="K->A: Loss of ligand-induced nuclear import; when associated with A-33 and A-34."; /evidence="ECO:0000269|PubMed:24692551"; MUTAGEN 33; /note="R->A: Loss of ligand-induced nuclear import; when associated with A-24 and A-34."; /evidence="ECO:0000269|PubMed:24692551"; MUTAGEN 34; /note="K->A: Loss of ligand-induced nuclear import; when associated with A-24 and A-33."; /evidence="ECO:0000269|PubMed:24692551
uniprot
proteins
protein_family
Calycin superfamily
uniprot
proteins
protein_family
Fatty-acid binding protein (FABP) family
uniprot
proteins
pubmed
10493790
uniprot
proteins
pubmed
12049637
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
1286667
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
1512466
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21395585
uniprot
proteins
pubmed
22170058
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24531463
uniprot
proteins
pubmed
24692551
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
8092987
uniprot
proteins
sequence_length
135
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24692551, ECO:0000269|PubMed:8092987}. Nucleus {ECO:0000269|PubMed:24692551}. Synapse {ECO:0000250|UniProtKB:Q05816}. Postsynaptic density {ECO:0000250|UniProtKB:Q05816}. Secreted {ECO:0000250|UniProtKB:Q05816}. Note=Localizes primarily to the cytoplasm. Upon certain ligand binding, a conformation change exposes a nuclear localization motif and the protein is transported into nucleus (PubMed:24692551). Secreted by astrocytes, but not by neurons (By similarity). {ECO:0000250|UniProtKB:Q05816, ECO:0000269|PubMed:24692551}.
uniprot
proteins