Irx6
entrez
64379
canonical
uniprot
Q9ER75
canonical
ensembl
ENSMUSG00000031738
resolver
ensp
ENSMUSP00000034185
resolver
ensp
ENSMUSP00000127446
resolver
enst
ENSMUST00000034185
resolver
enst
ENSMUST00000167261
resolver
genesymbol
Irx6
resolver
genesymbol_syn
Irxb3
resolver
uniprot
A1L3D2
resolver
uniprot
E9Q2V2
resolver
uniprot
F8WIL2
resolver
uniprot
Q8BFT1
resolver
uniprot_entry
F8WIL2_MOUSE
resolver
uniprot_entry
IRX6_MOUSE
resolver
uniprot_entry
Q8BFT1_MOUSE
resolver
uniprot_sec
A1L3D2
resolver
uniprot_sec
E9Q2V2
resolver
amino_acid_sequence
MAFSPFGHPYGSTSQFLVSASSSATCCETAPRPVSDVASASTSASTLCCTPYDSRLLGSARPELGAALGIYGAPYAAAQSYPGYLTYGPEPPTLCGALNPQYEFKDAAGSFAPSLTQPGAYYPYETTLGQYQYDRYGGVELSSAGRRKNATRESTSALKAWLHEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPKNKGGEERKADSGEDSLGCLNGDTKDATASQEARGLRLSDLEDLEEEEEEEEAEEEAAVSAARRLADFQKSTQPLPAPCAAAQERCLESRECGLGLPRFSFTEAPQSGEADFITAEPGGPTMILHYPSGHKPRIWSLAHTAAASAVESAPSTPPRAQSPECHMIPRQPSSIRRLLVPRDSEGEEDSPAAKAFGNSTFTLQGLPLNCAPYPRRREPEVRFQYPSGAEG
uniprot
proteins
function
FUNCTION: Transcription factor (PubMed:23172916). Binds to the iroquois binding site (IBS) motif of target genes to regulate gene expression; functions as a transcriptional activator or repressor (PubMed:23172916). Modulates expression of RCVRN, VSX1, BHLHE22/BHLHB5 and TACR3/Nk3r (PubMed:23172916). Required downstream of retinal bipolar cell specification for the terminal differentiation of type 2, type 3a and possibly type 6 bipolar cells (PubMed:23172916). {ECO:0000269|PubMed:23172916}.
uniprot
proteins
mass_dalton
47352
uniprot
proteins
protein_family
TALE/IRO homeobox family
uniprot
proteins
pubmed
11042145
uniprot
proteins
pubmed
11335133
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23172916
uniprot
proteins
sequence_length
438
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
uniprot
proteins