CLSTN1
entrez
22883
canonical
uniprot
O94985
canonical
ensembl
ENSG00000171603
resolver
ensp
ENSP00000354997
resolver
ensp
ENSP00000366513
resolver
ensp
ENSP00000602522
resolver
genesymbol
CLSTN1
resolver
genesymbol_syn
CS1
resolver
genesymbol_syn
KIAA0911
resolver
hgnc
HGNC:17447
resolver
uniprot
A8K183
resolver
uniprot
B4E3Q1
resolver
uniprot
Q5SR52
resolver
uniprot
Q5UE58
resolver
uniprot
Q71MN0
resolver
uniprot
Q8N4K9
resolver
uniprot_entry
B4E3Q1_HUMAN
resolver
uniprot_entry
CSTN1_HUMAN
resolver
uniprot_sec
A8K183
resolver
uniprot_sec
Q5SR52
resolver
uniprot_sec
Q5UE58
resolver
uniprot_sec
Q71MN0
resolver
uniprot_sec
Q8N4K9
resolver
amino_acid_sequence
MLRRPAPALAPAARLLLAGLLCGGGVWAARVNKHKPWLEPTYHGIVTENDNTVLLDPPLIALDKDAPLRFAESFEVTVTKEGEICGFKIHGQNVPFDAVVVDKSTGEGVIRSKEKLDCELQKDYSFTIQAYDCGKGPDGTNVKKSHKATVHIQVNDVNEYAPVFKEKSYKATVIEGKQYDSILRVEAVDADCSPQFSQICSYEIITPDVPFTVDKDGYIKNTEKLNYGKEHQYKLTVTAYDCGKKRATEDVLVKISIKPTCTPGWQGWNNRIEYEPGTGALAVFPNIHLETCDEPVASVQATVELETSHIGKGCDRDTYSEKSLHRLCGAAAGTAELLPSPSGSLNWTMGLPTDNGHDSDQVFEFNGTQAVRIPDGVVSVSPKEPFTISVWMRHGPFGRKKETILCSSDKTDMNRHHYSLYVHGCRLIFLFRQDPSEEKKYRPAEFHWKLNQVCDEEWHHYVLNVEFPSVTLYVDGTSHEPFSVTEDYPLHPSKIETQLVVGACWQEFSGVENDNETEPVTVASAGGDLHMTQFFRGNLAGLTLRSGKLADKKVIDCLYTCKEGLDLQVLEDSGRGVQIQAHPSQLVLTLEGEDLGELDKAMQHISYLNSRQFPTPGIRRLKITSTIKCFNEATCISVPPVDGYVMVLQPEEPKISLSGVHHFARAASEFESSEGVFLFPELRIISTITREVEPEGDGAEDPTVQESLVSEEIVHDLDTCEVTVEGEELNHEQESLEVDMARLQQKGIEVSSSELGMTFTGVDTMASYEEVLHLLRYRNWHARSLLDRKFKLICSELNGRYISNEFKVEVNVIHTANPMEHANHMAAQPQFVHPEHRSFVDLSGHNLANPHPFAVVPSTATVVIVVCVSFLVFMIILGVFRIRAAHRRTMRDQDTGKENEMDWDDSALTITVNPMETYEDQHSSEEEEEEEEEEESEDGEEEDDITSAESESSEEEEGEQGDPQNATRQQQLEWDDSTLSY
uniprot
proteins
function
FUNCTION: Postsynaptic adhesion molecule that binds to presynaptic neurexins to mediate both excitatory and inhibitory synapse formation (By similarity). Promotes synapse development by acting as a cell adhesion molecule at the postsynaptic membrane, which associates with neurexin-alpha at the presynaptic membrane (By similarity). Also functions as a cargo in axonal anterograde transport by acting as a molecular adapter that promotes KLC1 association with vesicles (PubMed:21385839). Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation (PubMed:12972431). {ECO:0000250|UniProtKB:Q99JH7, ECO:0000250|UniProtKB:Q9EPL2, ECO:0000269|PubMed:12972431, ECO:0000269|PubMed:21385839}.; FUNCTION: [Soluble Alc-alpha]: As intracellular fragment AlcICD, suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding (PubMed:15037614). {ECO:0000305|PubMed:15037614}.; FUNCTION: [CTF1-alpha]: In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP (PubMed:15037614). {ECO:0000305|PubMed:15037614}.
uniprot
proteins
mass_dalton
109793
uniprot
proteins
mutagenesis
MUTAGEN 913..914; /note="NP->AA: Abolishes interaction with APBA2."; /evidence="ECO:0000269|PubMed:12972431"; MUTAGEN 918; /note="Y->A: No effect on APBA2-binding."; /evidence="ECO:0000269|PubMed:12972431
uniprot
proteins
post_translational_modification
PTM: Proteolytically processed under normal cellular conditions (PubMed:15037614). A primary zeta-cleavage generates a large extracellular (soluble) N-terminal domain (sAlc) and a short C-terminal transmembrane fragment (CTF1) (PubMed:15037614). A secondary cleavage catalyzed by presenilin gamma-secretase within the transmembrane domain releases the beta-Alc-alpha chain in the extracellular milieu and produces an intracellular fragment (AlcICD) (PubMed:15037614). This processing is strongly suppressed in the tripartite complex formed with APBA2 and APP, which seems to prevent the association with PSEN1 (PubMed:15037614). {ECO:0000269|PubMed:15037614}.
uniprot
proteins
protein_family
Calsyntenin family
uniprot
proteins
pubmed
10048485
uniprot
proteins
pubmed
12498782
uniprot
proteins
pubmed
12972431
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15037614
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17332754
uniprot
proteins
pubmed
21385839
uniprot
proteins
sequence_length
981
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9EPL2}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:17332754}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:17332754, ECO:0000269|PubMed:21385839}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, neuron projection {ECO:0000269|PubMed:17332754}. Note=Localized in the postsynaptic membrane of both excitatory and inhibitory synapses. {ECO:0000250|UniProtKB:Q9EPL2}.; SUBCELLULAR LOCATION: [Soluble Alc-alpha]: Nucleus {ECO:0000269|PubMed:17332754}. Note=The AlcICD fragment is translocated to the nucleus upon interaction with APBB1. {ECO:0000269|PubMed:17332754}.
uniprot
proteins
transmembrane_region
TRANSMEM 860..880; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins