Kif12
entrez
16552
canonical
uniprot
Q9D2Z8
canonical
ensembl
ENSMUSG00000028357
resolver
ensp
ENSMUSP00000030042
resolver
ensp
ENSMUSP00000152690
resolver
enst
ENSMUST00000030042
resolver
enst
ENSMUST00000156618
resolver
genesymbol
Kif12
resolver
uniprot
A0A1Y7VK29
resolver
uniprot
O35061
resolver
uniprot_entry
A0A1Y7VK29_MOUSE
resolver
uniprot_entry
KIF12_MOUSE
resolver
uniprot_sec
O35061
resolver
amino_acid_sequence
MEERGSPDGDPARNLEQGPEGSETPIQVVLRVRPMSTVELRRGEQSALHCSGTRTLQVSPDVAFRFGAVLDGARTQEDVFRACGVKRLGELALRGFSCTVFTFGQTGSGKTYTLTGPPPQGEGVPVPPSLAGIMQRTFTWLLDRVQHLDSPVTLRASYLEIYNEQVWDLLSLGSPRPLPVRWTKARGFYVEQLRVVEFGSLEALMELLQMGLSRRRSSSHTLNQASSRSHALLTLHISRPTSQQVPPVDLGEPPVGGKLCFVDLAGSEKVAATGSQGQLMLEANSINRSLLALGHCISLLLDPQRKQNHIPFRDSKLTKLLADSLGGRGVTLMVACVSPSAQCLPETLSTLRYASRAQRITTRPQGPKSPGVKPPQQVENELLRLQEENRHLRFQLDQMHTTAPGAHGARMAWAQRNLYGMLQEFMLENERLRKEMRQLRSSRDLARAEQRVLAQQVHDLERRLLSACPLPQQGSTPVCPCRMVPAASCHALPPLCYCHHFCPLCRVPLAHWTCPRRECHMPQVLEPEAPGHISQSVWPPPWAPPPSPGSAKPPRERSQSDWTQTRVLAEMLMGEEVVPSAPPLSAGPSNMPYGLRGGSGIPNLTPRLETLTQQINSSLHLSQRQPQPSEDTQSPGQGLSSC
uniprot
proteins
function
FUNCTION: Involved in the negative regulation of fatty acid biosynthesis, probably acting as an adapter that allows ubiquitination of acetyl-CoA carboxylase 1 (ACACA) by E3 ubiquitin-protein ligase COP1, and promotes ACACA degradation (PubMed:39920308). The adapter function requires the C-terminal proline-rich domain and may be apart from the kinesin motor activity (Probable). {ECO:0000269|PubMed:39920308, ECO:0000305|PubMed:39920308}.
uniprot
proteins
mass_dalton
70706
uniprot
proteins
mutagenesis
MUTAGEN 363..642; /note="Missing: Homozygous mice have features of liver steatosis with elevated liver triacylglycerol levels."; /evidence="ECO:0000269|PubMed:39920308
uniprot
proteins
protein_family
Kinesin family
uniprot
proteins
protein_family
TRAFAC class myosin-kinesin ATPase superfamily
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26295839
uniprot
proteins
pubmed
30250217
uniprot
proteins
pubmed
39920308
uniprot
proteins
pubmed
9275178
uniprot
proteins
sequence_length
642
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}. Cell projection, cilium {ECO:0000269|PubMed:26295839}.
uniprot
proteins