REDIC1
entrez
283461
canonical
uniprot
Q86WS4
canonical
ensembl
ENSG00000180116
resolver
ensp
ENSP00000317671
resolver
ensp
ENSP00000383897
resolver
genesymbol
REDIC1
resolver
genesymbol_syn
C12orf40
resolver
hgnc
HGNC:26846
resolver
uniprot
B7WNU1
resolver
uniprot
Q8IXY6
resolver
uniprot
Q8N818
resolver
uniprot
V9HW02
resolver
uniprot_entry
RDIC1_HUMAN
resolver
uniprot_sec
B7WNU1
resolver
uniprot_sec
Q8IXY6
resolver
uniprot_sec
Q8N818
resolver
uniprot_sec
V9HW02
resolver
amino_acid_sequence
MNWVGGSRSRVLIKQERRKQKEYFEKHRLKSKMKSLGVLSPVKNSAVSLDILNLYMVNQISCKKKIPETVRKPTHVNMNRDIKMPLRKHNLELTMSPHCVPSKLCLDDTETNVNCQRLSSKEDLGPVQSQGMDSYSMLHPQFSKIENCSFTPSSFSVELPSNRHISKLNFTSGIAPTPQKLAYEKKQNDQRSTVNCSDSLLSKLNKSQDVFSPSHKTTRFGTLFERLNSLGNRNLLTKSPAVIMDEDCRSTDEIRQSDYITEKHSIQHIWGKNGKEVSNFLEDVNQSTPNLLSENCDSFVSQNMINVLNIDEQRIKKTFNKCDYDSMGDTCVVTSSDKNHVTDRCIRNIFTVPELTFSNSTLNKTSYPEKCQPNKKYQREYNKNERNDLSTSFENDYYPSSSERKEKFENDYQEKTPQKSIQKYPANSMGNIPSEELHSKQSWDFGLDEILMEEGGIYSLKSKRISTKKISLDSAQSSRSTSYSPRPTDSCFSSSSDLPSEDEDQISQQIEDSNRMTIKTKEKMNNFYVERMAKLSGDRIVKNDDKIHKQNENFYQFSVKNNTDQFPQLQCNSAHILQNKTNDNCVLQAARCDAGIQTESESVMEEKLDVAIQCDLISKCTCRSDVSLCNLERCSGNIKADTTGGQEIHKNN
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in this gene may cause non-obstructive azoospermia. {ECO:0000269|PubMed:37604834, ECO:0000269|PubMed:37612290}.
uniprot
proteins
function
FUNCTION: Involved in recombination, probably acting by stabilizing recombination intermediates during meiotic crossover formation. Required for normal germline development and fertility. Required for meiotic progression, complete chromosomal synapsis and crossover formation. Binds double-stranded DNA. However, also binds branched DNA molecules, such as those containing a D-loop or Holliday junction structure. Probably not required for formation of DNA double-strand breaks (DSBs). Also binds RNA in an RNA structure-independent manner, with a preference for binding 3'-UTR regions of mRNAs; may stabilize bound RNAs. {ECO:0000250|UniProtKB:A0A087WRU1}.
uniprot
proteins
mass_dalton
74505
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
37604834
uniprot
proteins
pubmed
37612290
uniprot
proteins
sequence_length
652
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:A0A087WRU1}. Note=In pachytene spermatocytes, localized along autosomal axes and the synapsed pseudoautosomal region on sex chromosomes, decreasing rapidly after early pachytene, by mid- or late pachytene, and disappearing in the diplotene stage. Also detected on the paired regions of homologous chromosomes in zygotene and pachytene oocytes, colocalizing with MSH4. Chromosomal localization of REDIC1 is mainly dependent on meiotic DNA double-strand breaks (DSBs) and interhomolog strand invasion. In spermatocytes from early zygotene to early pachytene, more than 90% of REDIC1 foci colocalize with RPA2. Probably localizes first to recombination intermediates and later colocalizes with MLH1 at crossover sites. {ECO:0000250|UniProtKB:A0A087WRU1}.
uniprot
proteins