EFNB2
entrez
1948
canonical
uniprot
P52799
canonical
ensembl
ENSG00000125266
resolver
ensp
ENSP00000493716
resolver
ensp
ENSP00000625503
resolver
enst
ENST00000646441
resolver
genesymbol
EFNB2
resolver
genesymbol_syn
EPLG5
resolver
genesymbol_syn
HTKL
resolver
genesymbol_syn
LERK5
resolver
hgnc
HGNC:3227
resolver
uniprot
Q5JV56
resolver
uniprot_entry
EFNB2_HUMAN
resolver
uniprot_sec
Q5JV56
resolver
amino_acid_sequence
MAVRRDSVWKYCWGVLMVLCRTAISKSIVLEPIYWNSSNSKFLPGQGLVLYPQIGDKLDIICPKVDSKTVGQYEYYKVYMVDKDQADRCTIKKENTPLLNCAKPDQDIKFTIKFQEFSPNLWGLEFQKNKDYYIISTSNGSLEGLDNQEGGVCQTRAMKILMKVGQDASSAGSTRNKDPTRRPELEAGTNGRSSTTSPFVKPNPGSSTDGNSAGHSGNNILGSEVALFAGIASGCIIFIVIIITLVVLLLKYRRRHRKHSPQHTTTLSLSTLATPKRSGNNNGSEPSDIIIPLRTADSVFCPHYEKVSGDYGHPVYIVQEMPPQSPANIYYKV
uniprot
proteins
function
FUNCTION: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. {ECO:0000269|PubMed:12734395}.; FUNCTION: (Microbial infection) Acts as a receptor for Hendra virus and Nipah virus. {ECO:0000269|PubMed:15998730, ECO:0000269|PubMed:16007075, ECO:0000269|PubMed:16477309, ECO:0000269|PubMed:17376907}.
uniprot
proteins
mass_dalton
36923
uniprot
proteins
mutagenesis
MUTAGEN 121..122; /note="LW->YM: Complete loss of Nipah protein G binding."; /evidence="ECO:0000269|PubMed:16477309
uniprot
proteins
post_translational_modification
PTM: Inducible phosphorylation of tyrosine residues in the cytoplasmic domain. {ECO:0000250}.
uniprot
proteins
protein_family
Ephrin family
uniprot
proteins
pubmed
12734395
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15998730
uniprot
proteins
pubmed
16007075
uniprot
proteins
pubmed
16477309
uniprot
proteins
pubmed
16867992
uniprot
proteins
pubmed
17376907
uniprot
proteins
pubmed
18488039
uniprot
proteins
pubmed
19836338
uniprot
proteins
pubmed
19875447
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
28931592
uniprot
proteins
pubmed
7534404
uniprot
proteins
pubmed
8559144
uniprot
proteins
pubmed
9533549
uniprot
proteins
sequence_length
333
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28931592}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P52800}.
uniprot
proteins
transmembrane_region
TRANSMEM 230..250; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins