Adra1a
entrez
11549
canonical
uniprot
P97718
canonical
ensembl
ENSMUSG00000045875
resolver
ensp
ENSMUSP00000053703
resolver
ensp
ENSMUSP00000124322
resolver
ensp
ENSMUSP00000124570
resolver
ensp
ENSMUSP00000125354
resolver
ensp
ENSMUSP00000153103
resolver
ensp
ENSMUSP00000312732
resolver
ensp
ENSMUSP00000312734
resolver
ensp
ENSMUSP00000312736
resolver
ensp
ENSMUSP00000312737
resolver
ensp
ENSMUSP00000312738
resolver
ensp
ENSMUSP00000312744
resolver
enst
ENSMUST00000054661
resolver
enst
ENSMUST00000159068
resolver
enst
ENSMUST00000159365
resolver
enst
ENSMUST00000161339
resolver
enst
ENSMUST00000225182
resolver
genesymbol
Adra1a
resolver
genesymbol_syn
Adra1c
resolver
uniprot
A0A286YCR7
resolver
uniprot
F6TF61
resolver
uniprot
O54913
resolver
uniprot
Q8BUE5
resolver
uniprot
Q8BV77
resolver
uniprot
Q8BXZ4
resolver
uniprot
Q8BZV1
resolver
uniprot_entry
A0A286YCR7_MOUSE
resolver
uniprot_entry
ADA1A_MOUSE
resolver
uniprot_entry
F6TF61_MOUSE
resolver
uniprot_entry
Q8BUE5_MOUSE
resolver
uniprot_entry
Q8BXZ4_MOUSE
resolver
uniprot_entry
Q8BZV1_MOUSE
resolver
uniprot_sec
O54913
resolver
uniprot_sec
Q8BV77
resolver
amino_acid_sequence
MVLLSENASEGSNCTHPPAQVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVADLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPTIVTQRRGVRALLCVWALSLVISIGPLFGWRQQAPEDETICQINEEPGYVLFSALGSFYVPLTIILVMYCRVYVVAKRESRGLKSGLKTDKSDSEQVTLRIHRKNVPAEGSGVSSAKNKTHFSVRLLKFSREKKAAKTLGIVVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVLRIQCLRRRQSSKHALGYTLHPPSQAVEGQHRGMVRIPVGSGETFYKISKTDGVREWKFFSSMPQGSARITMPKDQSACTTARVRSKSFLQVCCCVGSSTPRPEENHQVPTIKIHTISLGENGEEV
uniprot
proteins
function
FUNCTION: Alpha-1 adrenergic receptors are G protein-coupled receptors for catecholamines that signal through the G(q) family of G proteins, including G(q) and G(11). Upon activation, they stimulate the phosphatidylinositol-calcium second messenger pathway, leading to calcium release from intracellular stores and activation of protein kinase C. ADRA1A binds the catecholamine ligands norepinephrine and epinephrine (By similarity). Can also couple to G(14) protein (By similarity). Nuclear ADRA1A forms heterooligomers with ADRA1B to regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. At the plasma membrane, ADRA1A interacts with CAVIN4/MURC to regulates ERK activation in cardiomyocytes, contributing to the regulation of cardiac hypertrophy (By similarity). Additionally, functions as a vasopressor in resistance arteries and plays a role in maintaining normal arterial blood pressure (PubMed:12093905). {ECO:0000250|UniProtKB:P18130, ECO:0000250|UniProtKB:P35348, ECO:0000269|PubMed:12093905}.
uniprot
proteins
mass_dalton
51744
uniprot
proteins
protein_family
ADRA1A sub-subfamily
uniprot
proteins
protein_family
Adrenergic receptor subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12093905
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
22120526
uniprot
proteins
pubmed
7595531
uniprot
proteins
pubmed
9630362
uniprot
proteins
sequence_length
466
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250|UniProtKB:P35348}; Multi-pass membrane protein. Cell membrane {ECO:0000250|UniProtKB:P35348}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:P35348}. Membrane, caveola {ECO:0000250|UniProtKB:P35348}. Note=Location at the nuclear membrane facilitates heterooligomerization and regulates ERK-mediated signaling in cardiac myocytes. Colocalizes with GNAQ, PLCB1 as well as LAP2 at the nuclear membrane of cardiac myocytes. Colocalizes with CAVIN4 and CAV3 at the plasma membrane and partly within the cytoplasm in cardiomyocytes. {ECO:0000250|UniProtKB:P35348}.
uniprot
proteins
transmembrane_region
TRANSMEM 28..51; /note="Helical; Name=1"; /evidence="ECO:0000250"; TRANSMEM 65..88; /note="Helical; Name=2"; /evidence="ECO:0000250"; TRANSMEM 100..122; /note="Helical; Name=3"; /evidence="ECO:0000250"; TRANSMEM 144..167; /note="Helical; Name=4"; /evidence="ECO:0000250"; TRANSMEM 182..205; /note="Helical; Name=5"; /evidence="ECO:0000250"; TRANSMEM 274..297; /note="Helical; Name=6"; /evidence="ECO:0000250"; TRANSMEM 306..329; /note="Helical; Name=7"; /evidence="ECO:0000250
uniprot
proteins