SH3BP1
entrez
23616
canonical
uniprot
Q9Y3L3
canonical
ensembl
ENSG00000100092
resolver
ensp
ENSP00000497104
resolver
genesymbol
SH3BP1
resolver
hgnc
HGNC:10824
resolver
uniprot
Q5R3N0
resolver
uniprot
Q6IBZ2
resolver
uniprot
Q6ZVL9
resolver
uniprot
Q96HQ5
resolver
uniprot
Q9NSQ9
resolver
uniprot_entry
3BP1_HUMAN
resolver
uniprot_sec
Q5R3N0
resolver
uniprot_sec
Q6IBZ2
resolver
uniprot_sec
Q6ZVL9
resolver
uniprot_sec
Q96HQ5
resolver
uniprot_sec
Q9NSQ9
resolver
amino_acid_sequence
MMKRQLHRMRQLAQTGSLGRTPETAEFLGEDLLQVEQRLEPAKRAAHNIHKRLQACLQGQSGADMDKRVKKLPLMALSTTMAESFKELDPDSSMGKALEMSCAIQNQLARILAEFEMTLERDVLQPLSRLSEEELPAILKHKKSLQKLVSDWNTLKSRLSQATKNSGSSQGLGGSPGSHSHTTMANKVETLKEEEEELKRKVEQCRDEYLADLYHFVTKEDSYANYFIRLLEIQADYHRRSLSSLDTALAELRENHGQADHSPSMTATHFPRVYGVSLATHLQELGREIALPIEACVMMLLSEGMKEEGLFRLAAGASVLKRLKQTMASDPHSLEEFCSDPHAVAGALKSYLRELPEPLMTFDLYDDWMRAASLKEPGARLQALQEVCSRLPPENLSNLRYLMKFLARLAEEQEVNKMTPSNIAIVLGPNLLWPPEKEGDQAQLDAASVSSIQVVGVVEALIQSADTLFPGDINFNVSGLFSAVTLQDTVSDRLASEELPSTAVPTPATTPAPAPAPAPAPAPALASAATKERTESEVPPRPASPKVTRSPPETAAPVEDMARRTKRPAPARPTMPPPQVSGSRSSPPAPPLPPGSGSPGTPQALPRRLVGSSLRAPTVPPPLPPTPPQPARRQSRRSPASPSPASPGPASPSPVSLSNPAQVDLGAATAEGGAPEAISGVPTPPAIPPQPRPRSLASETN
uniprot
proteins
function
FUNCTION: GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration (PubMed:21658605). Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions (PubMed:22891260). Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment (PubMed:26465210). It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (PubMed:24841563). {ECO:0000269|PubMed:21658605, ECO:0000269|PubMed:22891260, ECO:0000269|PubMed:24841563, ECO:0000269|PubMed:26465210}.
uniprot
proteins
mass_dalton
75713
uniprot
proteins
mutagenesis
MUTAGEN 312; /note="R->A: Probable loss of the GTPase activator activity. Loss of function in cell migration."; /evidence="ECO:0000269|PubMed:21658605
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21658605
uniprot
proteins
pubmed
22891260
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23223568
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24841563
uniprot
proteins
pubmed
26465210
uniprot
proteins
sequence_length
701
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection {ECO:0000269|PubMed:21658605, ECO:0000269|PubMed:24841563}. Cell junction, tight junction {ECO:0000269|PubMed:22891260}. Cell junction, adherens junction {ECO:0000269|PubMed:22891260}. Cell projection, phagocytic cup {ECO:0000269|PubMed:26465210}. Nucleus {ECO:0000269|PubMed:22891260}. Cytoplasm, cytosol {ECO:0000269|PubMed:22891260}. Note=Localizes at the leading edge of migrating cells (PubMed:21658605, PubMed:24841563). Accumulation at forming phagocytic cups is PI3 kinase/PI3K-dependent and is specific for sites of large particles engagement and their phosphatidylinositol 3,4,5-triphosphate membrane content (PubMed:26465210). {ECO:0000269|PubMed:21658605, ECO:0000269|PubMed:24841563, ECO:0000269|PubMed:26465210}.
uniprot
proteins