PPP2R2B
entrez
5521
canonical
uniprot
Q00005
canonical
ensembl
ENSG00000156475
resolver
ensp
ENSP00000336591
resolver
ensp
ENSP00000377931
resolver
ensp
ENSP00000377933
resolver
ensp
ENSP00000377935
resolver
ensp
ENSP00000377936
resolver
ensp
ENSP00000398779
resolver
ensp
ENSP00000421396
resolver
ensp
ENSP00000598225
resolver
genesymbol
PPP2R2B
resolver
hgnc
HGNC:9305
resolver
uniprot
A6NEJ2
resolver
uniprot
A8K102
resolver
uniprot
B3KPD0
resolver
uniprot
B7Z2F2
resolver
uniprot
B7Z304
resolver
uniprot
D3DQF7
resolver
uniprot
D3DQF8
resolver
uniprot
G3V149
resolver
uniprot_entry
2ABB_HUMAN
resolver
uniprot_sec
A6NEJ2
resolver
uniprot_sec
A8K102
resolver
uniprot_sec
B3KPD0
resolver
uniprot_sec
B7Z2F2
resolver
uniprot_sec
B7Z304
resolver
uniprot_sec
D3DQF7
resolver
uniprot_sec
D3DQF8
resolver
uniprot_sec
G3V149
resolver
amino_acid_sequence
MEEDIDTRKINNSFLRDHSYATEADIISTVEFNHTGELLATGDKGGRVVIFQREQESKNQVHRRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAYFLLSTNDKTVKLWKVSERDKRPEGYNLKDEEGRLRDPATITTLRVPVLRPMDLMVEATPRRVFANAHTYHINSISVNSDYETYMSADDLRINLWNFEITNQSFNIVDIKPANMEELTEVITAAEFHPHHCNTFVYSSSKGTIRLCDMRASALCDRHTKFFEEPEDPSNRSFFSEIISSISDVKFSHSGRYIMTRDYLTVKVWDLNMENRPIETYQVHDYLRSKLCSLYENDCIFDKFECVWNGSDSVIMTGSYNNFFRMFDRNTKRDVTLEASRENSKPRAILKPRKVCVGGKRRKDEISVDSLDFSKKILHTAWHPSENIIAVAATNNLYIFQDKVN
uniprot
proteins
disease_involvement
DISEASE: Spinocerebellar ataxia 12 (SCA12) [MIM:604326]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA12 is an autosomal dominant cerebellar ataxia (ADCA). {ECO:0000269|PubMed:10581021}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity (By similarity). Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
51710
uniprot
proteins
protein_family
Phosphatase 2A regulatory subunit B family
uniprot
proteins
pubmed
10581021
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1849734
uniprot
proteins
pubmed
25356899
uniprot
proteins
pubmed
25816751
uniprot
proteins
pubmed
26496226
uniprot
proteins
sequence_length
443
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Membrane {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}. Note=Under basal conditions, localizes to both cytosolic and mitochondrial compartments. Relocalizes from the cytosolic to the mitochondrial compartment during apoptosis. Its targeting to the outer mitochondrial membrane (OMM) involves an association with import receptors of the TOM complex and is required to promote proapoptotic activity (By similarity). {ECO:0000250}.
uniprot
proteins