Tnip1
entrez
57783
canonical
uniprot
Q9WUU8
canonical
ensembl
ENSMUSG00000020400
resolver
ensp
ENSMUSP00000018482
resolver
ensp
ENSMUSP00000099791
resolver
ensp
ENSMUSP00000099792
resolver
ensp
ENSMUSP00000104513
resolver
ensp
ENSMUSP00000104514
resolver
ensp
ENSMUSP00000104517
resolver
ensp
ENSMUSP00000195797
resolver
ensp
ENSMUSP00000195808
resolver
enst
ENSMUST00000018482
resolver
enst
ENSMUST00000102730
resolver
enst
ENSMUST00000102731
resolver
enst
ENSMUST00000108889
resolver
genesymbol
Tnip1
resolver
genesymbol_syn
Abin
resolver
genesymbol_syn
Naf1
resolver
uniprot
D3Z2W0
resolver
uniprot
E9QM75
resolver
uniprot
Q922A9
resolver
uniprot
Q922F7
resolver
uniprot
Q9EPP8
resolver
uniprot
Q9R0X3
resolver
uniprot_entry
D3Z2W0_MOUSE
resolver
uniprot_entry
E9QM75_MOUSE
resolver
uniprot_entry
TNIP1_MOUSE
resolver
uniprot_sec
Q922A9
resolver
uniprot_sec
Q922F7
resolver
uniprot_sec
Q9EPP8
resolver
uniprot_sec
Q9R0X3
resolver
amino_acid_sequence
MEGRGPYRIYDPGGSTPLGEVSAAFERLVEENTRLKGKMQGIKMLGELLEESQMEASRLRQKAEELVKDSELSPPTSAPSLVSFDDLAELTGQDTKVQVHPATSTAATTTATATTGNSMEKPEPASKSPSNGASSDFEVVPTEEQNSPETGSHPTNMMDLGPPPPEDSNLKLHLQRLETTLSVCAEEPDHSQLFTHLGRMALEFNRLASKVHKNEQRTSILQTLCEQLRQENEALKAKLDKGLEQRDLAAERLREENTELKKLLMNSSCKEGLCGQPSSPKPEGAGKKGVAGQQQASVMASKVPEAGAFGAAEKKVKLLEQQRMELLEVNKQWDQHFRSMKQQYEQKITELRQKLVDLQKQVTELEAEREQKQRDFDRKLLLAKSKIEMEETDKEQLTAEAKELRQKVRYLQDQLSPLTRQREYQEKEIQRLNKALEEALSIQASPSSPPAAFGSPEGVGGHLRKQELVTQNELLKQQVKIFEEDFQRERSDRERMNEEKEELKKQVEKLQAQVTLTNAQLKTLKEEEKAKEALKQQKRKAKASGERYHMEPHPEHVCGAYPYAYPPMPAMVPHHAYKDWSQIRYPPPPVPMEHPPPHPNSRLFHLPEYTWRPPCAGIRNQSSQVMDPPPDRPAEPESADNDCDGPQ
uniprot
proteins
function
FUNCTION: Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B-dependent gene expression by regulating TAX1BP1 and A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG (By similarity). Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1-dependent transcription. Increases cell surface CD4(T4) antigen expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this function implicates binding to polyubiquitin. Involved in leukocyte integrin activation during inflammation; this function is mediated by association with SELPLG and dependent on phosphorylation by SRC-family kinases. {ECO:0000250|UniProtKB:Q15025, ECO:0000269|PubMed:12586352, ECO:0000269|PubMed:21606507, ECO:0000269|PubMed:22011580}.
uniprot
proteins
mass_dalton
73050
uniprot
proteins
mutagenesis
MUTAGEN 477..478; /note="QQ->EE: Loss of inhibitory activity on TNF-induced NF-kappa-B activation; no effect on interaction with TNFAIP3."; /evidence="ECO:0000269|PubMed:12586352"; MUTAGEN 485..486; /note="DF->NA: Abolishes ubiquitin binding; loss of inhibitory activity on TNF-induced NF-kappa-B activation; no effect on interaction with TNFAIP3."; /evidence="ECO:0000269|PubMed:12586352, ECO:0000269|PubMed:18212736"; MUTAGEN 485; /note="D->N: Abolishes interaction with polyubiquitinated IRAK1."; /evidence="ECO:0000269|PubMed:21606507"; MUTAGEN 489..490; /note="ER->AA: Abolishes ubiquitin binding; loss of inhibitory activity on NF-kappa-B activation."; /evidence="ECO:0000269|PubMed:18212736"; MUTAGEN 493..494; /note="RE->AQ: Loss of inhibitory activity on TNF-induced NF-kappa-B activation; no effect on interaction with TNFAIP3."; /evidence="ECO:0000269|PubMed:12586352
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Tyr-565 by SRC-family kinases recruits phosphoinositide-3-kinase (PI3K) PIK3CD:p85 heterodimer which results in integrin activation and leukocyte adhesion to activated endothelium during inflammation. {ECO:0000250}.
uniprot
proteins
pubmed
10385526
uniprot
proteins
pubmed
11090181
uniprot
proteins
pubmed
11389905
uniprot
proteins
pubmed
12586352
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18212736
uniprot
proteins
pubmed
21606507
uniprot
proteins
pubmed
22011580
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
647
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner. {ECO:0000250}.
uniprot
proteins