Armc5
entrez
361653
canonical
uniprot
Q5PQP9
canonical
ensembl
ENSRNOG00000019935
resolver
ensembl
ENSRNOG00055027031
resolver
ensembl
ENSRNOG00060025357
resolver
ensembl
ENSRNOG00065015854
resolver
ensp
ENSRNOP00000027032
resolver
ensp
ENSRNOP00055038312
resolver
ensp
ENSRNOP00060036442
resolver
ensp
ENSRNOP00065020661
resolver
enst
ENSRNOT00000027032
resolver
enst
ENSRNOT00055046676
resolver
enst
ENSRNOT00060043912
resolver
enst
ENSRNOT00065026333
resolver
genesymbol
Armc5
resolver
uniprot_entry
ARMC5_RAT
resolver
amino_acid_sequence
MAAARPALTDSLSFCLAQLTAAAGEGPGGGKDPATNETALGRVLLALRTRHIKAAEGIERFRARGGLRPLVALLRRTAAAGPAPSQAASGSAPPSVASAGSSPGPAPAAESPLTLSAPMRLRKTLDLALSILANCCTEGACRSEVRRIGGILPLVTILQCVRIDSIQNRTARALGNLAMEPESCGDIHSAGAVPFLVESLTACQDSQCLQSIVRALRNLADSPQHRLALAQQGAVRPLAELLATAPDPALTSALVRALLELSRGCSRACAEQLSLGGGLGPLVSLASHPKRAIREAAILILANLCAQGLVRPALGNAGGVEVLLGELRRRRGPSGSSSASQQPLVRAVCLLCREAINRARLRDAGGLELLMGLLQDPGASAWHPRVVAALVGFLYDTGALGKLQALGLVPLLARQLCGEAGEEEEEGVEAASWDFPEERTSGQPEGGSFRSLRLWLISEGYAAGPGDISPDWSPERCPMPEPSESVSPTPGQTSMSTPRTLRKLGRVPAATTEEPWGQEGPALLLLSRFSQAPDPSGALVTGPALCGLLAYVTGAPGPPNPRALRILARLTCNPACLEAFVRSYGAALLRAWLVLGVSPDDWPVPHARPVHRSQHRELGEMLLQNLTVQAESPFGVGALTHLLLSGSPEDRVACALTVPFICRKPTLWRRLLLDQGGLRLLLTALTQPAPHPLFLFFAADSLSCLQGLVSPSASPVPLPDLPLELDSPSPCLYKPLLGPAPAPAPDLHFVLDSGLQLPAQRAASAAASPFFRALLSGSFAEAQMNLVPLRGLSPSAAWPVLHHLHGCRGCGAALGPIPPPGQPLLGSKAEEALEAAGRFLLPALEEELEEAVGRIHLSPQGGPESVGEVFRLGRPRLAAHCARWTLEPGQCPRKRALALTGLVEAAGEEAGPLTEALLAVVMGVES
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The BCR(ARMC5) complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the BCR(ARMC5) complex acts by mediating ubiquitination of Pol II subunit POLR2A phosphorylated at 'Ser-5' of the C-terminal domain (CTD), leading to POLR2A degradation. The BCR(ARMC5) complex acts in parallel of the integrator complex and is specific for RNA Pol II originating from the promoter-proximal zone: it does not ubiquitinate elongation-stalled RNA Pol II. The BCR(ARMC5) complex also acts as a regulator of fatty acid desaturation by mediating ubiquitination and degradation of SCAP-free SREBF1 and SREBF2. Involved in fetal development, T-cell function and adrenal gland growth homeostasis. Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production. {ECO:0000250|UniProtKB:Q96C12}.
uniprot
proteins
mass_dalton
96585
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q96C12}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex, leading to its degradation. Deubiquitinated by USP7. {ECO:0000250|UniProtKB:Q96C12}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
926
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96C12}. Chromosome {ECO:0000250|UniProtKB:Q96C12}. Cytoplasm {ECO:0000250|UniProtKB:Q96C12}. Note=Associates to RNA polymerase II (Pol II) on chromatin. {ECO:0000250|UniProtKB:Q96C12}.
uniprot
proteins