Gatad2b
entrez
229542
canonical
uniprot
Q8VHR5
canonical
ensembl
ENSMUSG00000042390
resolver
ensp
ENSMUSP00000142514
resolver
ensp
ENSMUSP00000142617
resolver
ensp
ENSMUSP00000322039
resolver
genesymbol
Gatad2b
resolver
uniprot
Q8C9Q3
resolver
uniprot_entry
P66B_MOUSE
resolver
uniprot_sec
Q8C9Q3
resolver
amino_acid_sequence
MDRMTEDALRLNLLKRSLDPADERDDVLAKRLKMEGHEAMERLKMLALLKRKDLANLEVPHELPTKQDGSGVKGYEEKLNGNLRPHGDNNRTAGRPGKENINDEPVDMSARRSEPDRGRLTPSPDIIVLSDNEASSPRSSSRMEERLKAANLEMFKGKGMEERQQLIKQLRDELRLEEARLVLLKKLRQSQLQKENVVQKTPVVQNAASIVQPSPAHVGQQGLSKLPSRPGAQGIEPQNMRTLQGHSVIRSATNTTLPHMLMSQRVIAPNPAQLQGQRGPPKPGIVRTTTPNMNPAISYQPQSSSSVPCQRTTSSAIYMNLASHIQPGTVNRVSSPLPSPSAMSDAANSQAAAKLALRKQLEKTLLEIPPPKPPAPLLHFLPSAANSEFIYMVGLEEVVQSVIDSQGKNCASLLRVEPFVCAQCRTDFTPHWKQEKNGKILCEQCMTSNQKKALKAEHTNRLKNAFVKALQQEQEIEQRLQQQAALSPTTAPAVSSVSKQETIMRHHTLRQAPQPQSSLQRGIPTSARSMLSNFAQAPQLSVPGGLLGMPGVNIAYLNTGIGGHKAPSLADRQREYLLDMIPPRSISQSISGQK
uniprot
proteins
function
FUNCTION: Transcriptional repressor. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus. May play a role in synapse development. {ECO:0000250|UniProtKB:Q8WXI9}.
uniprot
proteins
mass_dalton
65411
uniprot
proteins
pubmed
11756549
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
594
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q8WXI9}. Nucleus {ECO:0000250|UniProtKB:Q8WXI9}. Chromosome {ECO:0000250|UniProtKB:Q8WXI9}. Note=Speckled nuclear localization requires both CR1 and CR2 regions. Localizes to sites of DNA damage. {ECO:0000250|UniProtKB:Q8WXI9}.
uniprot
proteins