Asb2
entrez
299266
canonical
uniprot
Q5U2S6
canonical
ensembl
ENSRNOG00000051619
resolver
ensp
ENSRNOP00000071182
resolver
enst
ENSRNOT00000085517
resolver
genesymbol
Asb2
resolver
uniprot_entry
ASB2_RAT
resolver
amino_acid_sequence
MSTEISTRGRQRAIGHEEYSLYSSLSEEELVQMAIEQSLADKTRGPTPAETSVSSQTNHQPGHIHPWTRSSSPPESPPARAPLGLFQGVMQKYSSNLFKTSQMAAMDPVLKAIKEGDEEALKAMIQDGKNLAEPNKEGWLPLHEAAYYGKLGCLKVLQRAYPGTIDQRTLQEETALYLATCREHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAVRILVQYNADANHRCNRGWTALHESVSRNDLEVMEILVSGGAKVEAKNVYSITPLFVAAQSGQLEALRFLAKHGADINTQASDSASALYEACKNEHEDVVEFLLSQGADANKANKDGLLPLHVASKKGNYRIVQMLLPVTSRTRVRRSGISPLHLAAERNHDAVLEALLAARFDVNTPLAPERARLYEDRRTSALYFAVVNNNVYATELLLLAGADPNRDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPPAPRSGRFNDAPVDDKAPSVVQFCEFLSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIKLLDTLPLPGRLIRYLKYENTQ
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Mediates Notch-induced ubiquitination and degradation of substrates including E2A and JAK2 (By similarity). Required during embryonic heart development for complete heart looping (By similarity). Required for cardiomyocyte differentiation (By similarity). Involved in myogenic differentiation and targets filamin FLNB for proteasomal degradation but not filamin FLNA (By similarity). Also targets DES for proteasomal degradation (By similarity). Acts as a negative regulator of skeletal muscle mass (By similarity). {ECO:0000250|UniProtKB:Q8K0L0, ECO:0000250|UniProtKB:Q96Q27}.
uniprot
proteins
mass_dalton
70205
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated. {ECO:0000250|UniProtKB:Q96Q27}.
uniprot
proteins
protein_family
Ankyrin SOCS box (ASB) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
634
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:Q96Q27}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:Q8K0L0}. Note=Localizes to the Z line in cardiomyocytes. {ECO:0000250|UniProtKB:Q8K0L0}.
uniprot
proteins