Suv39h2
entrez
64707
canonical
uniprot
Q9EQQ0
canonical
ensembl
ENSMUSG00000026646
resolver
ensp
ENSMUSP00000027956
resolver
enst
ENSMUST00000027956
resolver
genesymbol
Suv39h2
resolver
uniprot
A0A0R4J074
resolver
uniprot
Q8BNK2
resolver
uniprot
Q9CUK3
resolver
uniprot
Q9JLP7
resolver
uniprot_entry
A0A0R4J074_MOUSE
resolver
uniprot_entry
SUV92_MOUSE
resolver
uniprot_sec
Q8BNK2
resolver
uniprot_sec
Q9CUK3
resolver
uniprot_sec
Q9JLP7
resolver
amino_acid_sequence
MATARAKARGSEAGARCHRAPGPPPRPKARRTARRRRAETLTARRSRPSAGERRAGSQRAWSGAPRAAVFGDECARGALFKAWCVPCLVSLDTLQELCRKEKLTCKSIGITKRNLNNYEVEYLCDYKVAKGVEYYLVKWKGWPDSTNTWEPLRNLRCPQLLRQFSDDKKTYLAQERKCKAVNSKSLQPAIAEYIVQKAKQRIALQRWQDYLNRRKNHKGMIFVENTVDLEGPPLDFYYINEYRPAPGISINSEATFGCSCTDCFFDKCCPAEAGVVLAYNKKQQIKIQPGTPIYECNSRCRCGPECPNRIVQKGTQYSLCIFKTSNGCGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFSVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMKGSGEASSDSIDHSPAKKRVRTQCKCGAETCRGYLN
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Histone methyltransferase that specifically mediates trimethylation of 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' (H3K9me1) as substrate (PubMed:11094092, PubMed:11701123, PubMed:14690609, PubMed:14690610, PubMed:14702045, PubMed:22939622). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones (By similarity). Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions (PubMed:14702045). H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats (By similarity). SUV39H2 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length (By similarity). May participate in regulation of higher-order chromatin organization during spermatogenesis (PubMed:11094092). Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation (PubMed:24413057). {ECO:0000250|UniProtKB:Q9H5I1, ECO:0000269|PubMed:11094092, ECO:0000269|PubMed:11701123, ECO:0000269|PubMed:14690609, ECO:0000269|PubMed:14690610, ECO:0000269|PubMed:14702045, ECO:0000269|PubMed:22939622, ECO:0000269|PubMed:24413057}.
uniprot
proteins
mass_dalton
54098
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the DCX(DCAF13) E3 ubiquitin ligase complex, leading to its degradation. {ECO:0000269|PubMed:30111536}.
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
Histone-lysine methyltransferase family
uniprot
proteins
protein_family
Suvar3-9 subfamily
uniprot
proteins
pubmed
11094092
uniprot
proteins
pubmed
11701123
uniprot
proteins
pubmed
14690609
uniprot
proteins
pubmed
14690610
uniprot
proteins
pubmed
14702045
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22939622
uniprot
proteins
pubmed
24413057
uniprot
proteins
pubmed
30111536
uniprot
proteins
pubmed
38961301
uniprot
proteins
sequence_length
477
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H5I1}. Chromosome {ECO:0000250|UniProtKB:Q9H5I1}. Chromosome, centromere {ECO:0000269|PubMed:11094092}. Note=Associates with centromeric constitutive heterochromatin (PubMed:11094092). Predominantly accumulates at the sex chromosomes present at the XY body (PubMed:11094092). Recruited to pericentromeric heterochromatin via its chromo domain, which specifically recognizes and binds histone H3 monoubiquitinated at 'Lys-14' (H3K14ub) (By similarity). {ECO:0000250|UniProtKB:Q9H5I1, ECO:0000269|PubMed:11094092}.
uniprot
proteins