Dmpk
entrez
13400
canonical
uniprot
P54265
canonical
ensembl
ENSMUSG00000030409
resolver
ensp
ENSMUSP00000032568
resolver
ensp
ENSMUSP00000104113
resolver
ensp
ENSMUSP00000104114
resolver
ensp
ENSMUSP00000158930
resolver
ensp
ENSMUSP00000185117
resolver
ensp
ENSMUSP00000185126
resolver
ensp
ENSMUSP00000185128
resolver
ensp
ENSMUSP00000185133
resolver
ensp
ENSMUSP00000185159
resolver
ensp
ENSMUSP00000185162
resolver
enst
ENSMUST00000108474
resolver
genesymbol
Dmpk
resolver
genesymbol_syn
Dm15
resolver
genesymbol_syn
Mdpk
resolver
uniprot
E9Q6J9
resolver
uniprot_entry
DMPK_MOUSE
resolver
uniprot_entry
E9Q6J9_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Coiled-coil-mediated oligomerization enhances the catalytic activity. Proteolytic processing of the C-terminus may release the protein from membranes and constitute a mean to regulate the enzyme. May be regulated by HSPB2, RAC1, RAF1 and G protein second messengers (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MSAEVRLRQLQQLVLDPGFLGLEPLLDLLLGVHQELGASHLAQDKYVADFLQWVEPIAARLKEVRLQRDDFEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVKGDRRWITQLHFAFQDENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIRLADFGSCLKLQPDGMVRSLVAVGTPDYLSPEILQAVGGGPGAGSYGPECDWWALGVFAYEMFYGQTPFYADSTAETYAKIVHYREHLSLPLADTVVPEEAQDLIRGLLCPAEIRLGRGGAGDFQKHPFFFGLDWEGLRDSVPPFTPDFEGATDTCNFDVVEDRLTAMVSGGGETLSDMQEDMPLGVRLPFVGYSYCCMAFRDNQVPDPTPMELEALQLPVSDLQGLDLQPPVSPPDQVAEEADLVAVPAPVAEAETTVTLQQLQEALEEEVLTRQSLSRELEAIRTANQNFSSQLQEAEVRNRDLEAHVRQLQERMEMLQAPGAAAITGVPSPRATDPPSHLDGPPAVAVGQCPLVGPGPMHRRHLLLPARIPRPGLSEARCLLLFAAALAAAATLGCTGLVAYTGGLTPVWCFPGATFAP
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity. {ECO:0000269|PubMed:12612014, ECO:0000269|PubMed:15598648, ECO:0000269|PubMed:18729234, ECO:0000269|PubMed:21949239, ECO:0000269|PubMed:9294109}.
uniprot
proteins
mass_dalton
69602
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Autophosphorylates. Phosphorylation by RAF1 may result in activation of DMPK (By similarity). {ECO:0000250}.; PTM: Proteolytic processing of the C-terminus may remove the transmembrane domain and release the kinase from membranes stimulating its activity. {ECO:0000250}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
DMPK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10699184
uniprot
proteins
pubmed
10936001
uniprot
proteins
pubmed
12612014
uniprot
proteins
pubmed
1302022
uniprot
proteins
pubmed
15598648
uniprot
proteins
pubmed
15684391
uniprot
proteins
pubmed
18729234
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21949239
uniprot
proteins
pubmed
8401505
uniprot
proteins
pubmed
8499920
uniprot
proteins
pubmed
8673132
uniprot
proteins
pubmed
9294109
uniprot
proteins
sequence_length
631
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane. Cell membrane. Note=Localizes to sarcoplasmic reticulum membranes of cardiomyocytes.; SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum membrane; Single-pass type IV membrane protein; Cytoplasmic side. Nucleus outer membrane; Single-pass type IV membrane protein; Cytoplasmic side.; SUBCELLULAR LOCATION: [Isoform 8]: Mitochondrion outer membrane; Single-pass type IV membrane protein.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm, cytosol.
uniprot
proteins
transmembrane_region
TRANSMEM 593..613; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins