Npepps
entrez
19155
canonical
uniprot
Q11011
canonical
ensembl
ENSMUSG00000001441
resolver
ensp
ENSMUSP00000001480
resolver
enst
ENSMUST00000001480
resolver
genesymbol
Npepps
resolver
genesymbol_syn
Psa
resolver
uniprot
Q3UZE0
resolver
uniprot
Q5PR74
resolver
uniprot
Q91VJ8
resolver
uniprot_entry
PSA_MOUSE
resolver
uniprot_sec
Q3UZE0
resolver
uniprot_sec
Q5PR74
resolver
uniprot_sec
Q91VJ8
resolver
activity_regulation
ACTIVITY REGULATION: Strongly inhibited by bestatin, leuhistin, actinonin, amastatin, 1,10-phenanthroline, DFP, PCMBS, Zn(2+), Cd(2+), Co(2+), Cu(2+), Hg(2+), EDTA and puromycin. Not inhibited by PMSF, and only slightly inhibited by leupeptin and aprotinin. Activity is increased by Mg(2+) and Ca(2+) (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MWLAAAVPSLARRLLLLGPPPPPLLLLLSRSSRRRRRLHSLGLAAMPEKRPFERLPAEVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGDEEIHATGFNYQNEDEKVTLSFPSTLQTGTGTLKIDFVGELNDKMKGFYRSRYTTPAGEVRYAAVTQFEATDARRAFPCWDEPAIKATFDISLVVPKDRVALSNMNVIDRKPYPDDENLVEVKFARTPVMSTYLVAFVVGEYDFVETRSKDGVCVRVYTPVGKAEQGKFALEVAAKTLPFYKDYFNVPYPLPKIDLIAIADFAAGAMENWGLVTYRETALLIDPKNSCSSSRQWVALVVGHELAHQWFGNLVTMEWWTHLWLNEGFASWIEYLCVDHCFPEYDIWTQFVSADYTRAQELDALDNSHPIEVSVGHPSEVDEIFDAISYSKGASVIRMLHDYIGDKDFKKGMNMYLTKFQQKNAATEDLWESLESASGKPIAAVMNTWTKQMGFPLIYVEAEQVEDDRVLKLSQKKFCASGPYGGEDCPQWMVPITISTSEDPNQAKLKILMDKPEMSVVLKNVKPDQWVKLNLGTVGFYRTQYSSAMLESLLPGIRDLSLPPVDRLGLQNDLFSLARAGIISTVEVLKVMEAFVNEPNYTVWSDLSCNLGILSTLLSHTDFYEEIQEFVKDVFSPIGERLGWDPKPGEGHLDALLRGLVLGKLGKAGHKATLEEARRRFKEHVEGKQILSADLRSPVYLTVLKHGDGATLDIMLKLHKQADMQEEKNRIERVLGATLSPELIQKVLTFALSEEVRPQDTVSVIGGVAGGSKHGRKAAWKFIKDNWEELHNRYQGGFLISRLIKLSVEGFAVDKMAGEVKAFFESHPAPSAERTIQQCCENILLNAAWLKRDADSIHQYLLQRKTSPPSV
uniprot
proteins
ec_number
3.4.11.14
uniprot
proteins
function
FUNCTION: Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. {ECO:0000269|PubMed:7592939}.
uniprot
proteins
mass_dalton
103325
uniprot
proteins
protein_family
Peptidase M1 family
uniprot
proteins
pubmed
10407043
uniprot
proteins
pubmed
11376108
uniprot
proteins
pubmed
11376114
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16800626
uniprot
proteins
pubmed
18209067
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7592939
uniprot
proteins
sequence_length
920
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:7592939}. Nucleus {ECO:0000269|PubMed:7592939}.
uniprot
proteins