Gtf2h3
entrez
209357
canonical
uniprot
Q8VD76
canonical
ensembl
ENSMUSG00000029387
resolver
ensp
ENSMUSP00000031333
resolver
enst
ENSMUST00000031333
resolver
genesymbol
Gtf2h3
resolver
uniprot
Q3UZB8
resolver
uniprot_entry
Q3UZB8_MOUSE
resolver
uniprot_entry
TF2H3_MOUSE
resolver
amino_acid_sequence
MAADEDELNLLVIIVDTNPIWWGKQALKESQFTLSKCMDAVMVLANSHLFMNRSNQLAVIASHIQESRLLYPGKNGGLGDFFGDPGNALPDCNPSGSKDGKYELLTVANEVIAEEIKDLMTKSDIKGQHTETLLAGSLAKALCYIHRVNKAVKDNQEMKSRILVIKAAEDSALQYMNFMNVIFAAQKQNILIDACVLDSDSGLLQQACDITGGLYLKVPQMPSLLQYLLWVFLPDQDQRSQLILPPPIHVDYRAACFCHRSLIEIGYVCSVCLSIFCNFSPICTTCETAFKISLPPVLKAKKKKQKVSL
uniprot
proteins
function
FUNCTION: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. {ECO:0000250|UniProtKB:Q13889}.
uniprot
proteins
mass_dalton
34244
uniprot
proteins
protein_family
TFB4 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9230306
uniprot
proteins
sequence_length
309
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13889}.
uniprot
proteins