Ndufab1
entrez
70316
canonical
uniprot
Q9CR21
canonical
ensembl
ENSMUSG00000030869
resolver
ensp
ENSMUSP00000033157
resolver
ensp
ENSMUSP00000102079
resolver
ensp
ENSMUSP00000116177
resolver
enst
ENSMUST00000033157
resolver
enst
ENSMUST00000123296
resolver
genesymbol
Ndufab1
resolver
uniprot
Q569N0
resolver
uniprot
Q9D726
resolver
uniprot
Q9D7V5
resolver
uniprot_entry
ACPM_MOUSE
resolver
uniprot_entry
Q569N0_MOUSE
resolver
uniprot_sec
Q9D726
resolver
uniprot_sec
Q9D7V5
resolver
amino_acid_sequence
MASRVLCACVRRLPAAFAPLPRLPTLALARPLSTTLCPEGIRRRPGALQSALALAQVPGTVTHLCRQYSDAPPLTLDGIKDRVLYVLKLYDKIDPEKLSVNSHFMKDLGLDSLDQVEIIMAMEDEFGFEIPDIDAEKLMCPQEIVDYIADKKDVYE
uniprot
proteins
function
FUNCTION: Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (PubMed:38575788). Accessory protein, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with LYRM4, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (By similarity). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). {ECO:0000250|UniProtKB:O14561, ECO:0000250|UniProtKB:P52505, ECO:0000250|UniProtKB:Q9H1K1, ECO:0000269|PubMed:38575788}.
uniprot
proteins
mass_dalton
17370
uniprot
proteins
post_translational_modification
PTM: Phosphopantetheinylation at Ser-112 is essential for interactions with LYR motif-containing proteins. {ECO:0000250|UniProtKB:P52505}.
uniprot
proteins
protein_family
Acyl carrier protein (ACP) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
38575788
uniprot
proteins
sequence_length
156
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:38575788}.
uniprot
proteins