IL3RA
entrez
3563
canonical
uniprot
P26951
canonical
ensembl
ENSG00000185291
resolver
ensembl
ENSG00000292332
resolver
ensp
ENSP00000327890
resolver
ensp
ENSP00000370878
resolver
ensp
ENSP00000518612
resolver
ensp
ENSP00000573884
resolver
ensp
ENSP00000573885
resolver
ensp
ENSP00000573887
resolver
ensp
ENSP00000815735
resolver
ensp
ENSP00000815791
resolver
ensp
ENSP00000815792
resolver
ensp
ENSP00000815794
resolver
genesymbol
IL3RA
resolver
genesymbol_syn
IL3R
resolver
hgnc
HGNC:6012
resolver
uniprot
A8K3F3
resolver
uniprot
B9VI81
resolver
uniprot
Q5HYQ7
resolver
uniprot
Q5HYQ8
resolver
uniprot
Q9UEH7
resolver
uniprot_entry
IL3RA_HUMAN
resolver
uniprot_sec
A8K3F3
resolver
uniprot_sec
B9VI81
resolver
uniprot_sec
Q5HYQ7
resolver
uniprot_sec
Q5HYQ8
resolver
uniprot_sec
Q9UEH7
resolver
amino_acid_sequence
MVLLWLTLLLIALPCLLQTKEDPNPPITNLRMKAKAQQLTWDLNRNVTDIECVKDADYSMPAVNNSYCQFGAISLCEVTNYTVRVANPPFSTWILFPENSGKPWAGAENLTCWIHDVDFLSCSWAVGPGAPADVQYDLYLNVANRRQQYECLHYKTDAQGTRIGCRFDDISRLSSGSQSSHILVRGRSAAFGIPCTDKFVVFSQIEILTPPNMTAKCNKTHSFMHWKMRSHFNRKFRYELQIQKRMQPVITEQVRDRTSFQLLNPGTYTVQIRARERVYEFLSAWSTPQRFECDQEEGANTRAWRTSLLIALGTLLALVCVFVICRRYLVMQRLFPRIPHMKDPIGDSFQNDKLVVWEAGKAGLEECLVTEVQVVQKT
uniprot
proteins
function
FUNCTION: Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells (PubMed:10527461). Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program (By similarity). {ECO:0000250|UniProtKB:P26952, ECO:0000269|PubMed:10527461, ECO:0000269|PubMed:29374162}.
uniprot
proteins
mass_dalton
43330
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by RNFT2 in response to IL3. Ubiquitination leads ligand-induced degradation by the proteasome. Ubiquitinated by RNF128 via 'Lys-27'-linked polyubiquitination, facilitating its degradation through the lysosomal pathway (PubMed:38702781). {ECO:0000250|UniProtKB:P26952, ECO:0000269|PubMed:38702781}.
uniprot
proteins
protein_family
Type 5 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
10527461
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
1833064
uniprot
proteins
pubmed
19109256
uniprot
proteins
pubmed
25043189
uniprot
proteins
pubmed
29374162
uniprot
proteins
pubmed
38702781
uniprot
proteins
pubmed
7887951
uniprot
proteins
sequence_length
378
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:38702781}; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 306..325; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins