Dusp7
entrez
300980
canonical
uniprot
Q63340
canonical
ensembl
ENSRNOG00000010789
resolver
ensp
ENSRNOP00000014770
resolver
enst
ENSRNOT00000014770
resolver
genesymbol
Dusp7
resolver
genesymbol_syn
Mkpx
resolver
uniprot
F1M7V9
resolver
uniprot_entry
DUS7_RAT
resolver
uniprot_sec
F1M7V9
resolver
activity_regulation
ACTIVITY REGULATION: Strongly inhibited by sodium orthovanadate. {ECO:0000250|UniProtKB:Q16829}.
uniprot
proteins
amino_acid_sequence
MKNQLRGPPVRAHMSTSGAAAAGGTRAGSEPGAGSGSSAGIGAGATTGAGAMPCKSAEWLQEELEARGGASLLLLDCRPHELFESSHIETAINLAIPGLMLRRLRKGNLPIRSIIPNHADKERFATRCKAATVLLYDEATAEWQPEPGAPASVLGLLLQKLRDDGCQAYYLQGGFNKFQTEYSEHCETNVDSSSSPSGSPPTSVLGLGGLRISSDCSDGESDRELPSSATESDGSPVPSSQPAFPVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTLGLSSPCDNHTPSEQLYFSTPTNHNLFPINTLEST
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Dual specificity protein phosphatase (By similarity). Shows high activity towards MAPK1/ERK2 (By similarity). Also has lower activity towards MAPK14 and MAPK8 (By similarity). In arrested oocytes, plays a role in meiotic resumption. Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB. May also inactivate PRKCA and/or PRKCG. Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex. {ECO:0000250|UniProtKB:Q16829, ECO:0000250|UniProtKB:Q91Z46}.
uniprot
proteins
mass_dalton
45067
uniprot
proteins
protein_family
Non-receptor class dual specificity subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
27783954
uniprot
proteins
pubmed
8626780
uniprot
proteins
sequence_length
419
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q16829}.
uniprot
proteins