Ajuba
entrez
16475
canonical
uniprot
Q91XC0
canonical
ensembl
ENSMUSG00000022178
resolver
ensp
ENSMUSP00000056977
resolver
enst
ENSMUST00000054487
resolver
genesymbol
Ajuba
resolver
genesymbol_syn
Jub
resolver
uniprot
P97472
resolver
uniprot_entry
AJUBA_MOUSE
resolver
uniprot_sec
P97472
resolver
amino_acid_sequence
MERLGEKASRLLEKLRLSDSGSAKFGRRKGEASRSGSDGTPGAGKGRLSGLGGPRKSGHRGANGGPGDEPLEPAREQGPLDAERNARGSFEAQRFEGSFPGGPPPTRALPLPLSSPPDFRLETTAPALSPRSSFASSSASDASKPSSPRGSLLLDGAGASGAGGSRPCSNRTSGISMGYDQRHGSPLPAGPCLFGLPLTTAPAGYPGGAPSAYPELHAALDRLCAHRSVGFGCQESRHSYPPALGSPGALTGAVVGTAGPLERRGAQPGRHSVTGYGDCAAGARYQDELTALLRLTVATGGREAGARGEPSGIEPSGLEESPGPFVPEASRSRIREPEAREDYFGTCIKCNKGIYGQSNACQALDSLYHTQCFVCCSCGRTLRCKAFYSVNGSVYCEEDYLFSGFQEAAEKCCVCGHLILEKILQAMGKSYHPGCFRCIVCNKCLDGVPFTVDFSNQVYCVTDYHKNYAPKCAACGQPILPSEGCEDIVRVISMDRDYHFECYHCEDCRMQLSDEEGCCCFPLDGHLLCHGCHMQRLSARQPSTNYI
uniprot
proteins
function
FUNCTION: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. {ECO:0000269|PubMed:10330178, ECO:0000269|PubMed:11029037, ECO:0000269|PubMed:15728191, ECO:0000269|PubMed:17909014, ECO:0000269|PubMed:18331720}.
uniprot
proteins
mass_dalton
57920
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by LATS2 during mitosis. Phosphorylated by AURKA (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Zyxin/ajuba family
uniprot
proteins
pubmed
10330178
uniprot
proteins
pubmed
11029037
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15728191
uniprot
proteins
pubmed
15870270
uniprot
proteins
pubmed
17909014
uniprot
proteins
pubmed
18331720
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
547
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cell membrane {ECO:0000250}. Cell junction {ECO:0000250}. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, P-body {ECO:0000250}. Note=Shuttles between the cytoplasm and the nucleus. Localizes on centrosomes during G2-M phase (By similarity). Preferentially colocalizes with cadherin-adhesive complexes at sites of cell-cell contacts (By similarity). Colocalizes with GFI1 in the nucleus (By similarity). {ECO:0000250}.
uniprot
proteins