Oas1a
entrez
246730
canonical
uniprot
P11928
canonical
ensembl
ENSMUSG00000052776
resolver
ensp
ENSMUSP00000079198
resolver
ensp
ENSMUSP00000209926
resolver
ensp
ENSMUSP00000335231
resolver
ensp
ENSMUSP00000335232
resolver
ensp
ENSMUSP00000335233
resolver
enst
ENSMUST00000080322
resolver
genesymbol
Oas1a
resolver
genesymbol_syn
Oias1
resolver
uniprot
F2Z419
resolver
uniprot
Q3UEC1
resolver
uniprot
Q64440
resolver
uniprot
Q91VI0
resolver
uniprot_entry
OAS1A_MOUSE
resolver
uniprot_sec
F2Z419
resolver
uniprot_sec
Q3UEC1
resolver
uniprot_sec
Q64440
resolver
uniprot_sec
Q91VI0
resolver
activity_regulation
ACTIVITY REGULATION: Produced as a latent enzyme which is activated by dsRNA generated during the course of viral infection. The dsRNA activator must be at least 15 nucleotides long, and no modification of the 2'-hydroxyl group is tolerated. ssRNA or dsDNA do not act as activators.
uniprot
proteins
amino_acid_sequence
MEHGLRSIPAWTLDKFIEDYLLPDTTFGADVKSAVNVVCDFLKERCFQGAAHPVRVSKVVKGGSSGKGTTLKGKSDADLVVFLNNLTSFEDQLNRRGEFIKEIKKQLYEVQHERRFRVKFEVQSSWWPNARSLSFKLSAPHLHQEVEFDVLPAFDVLGHVNTSSKPDPRIYAILIEECTSLGKDGEFSTCFTELQRNFLKQRPTKLKSLIRLVKHWYQLCKEKLGKPLPPQYALELLTVFAWEQGNGCYEFNTAQGFRTVLELVINYQHLRIYWTKYYDFQHQEVSKYLHRQLRKARPVILDPADPTGNVAGGNPEGWRRLAEEADVWLWYPCFIKKDGSRVSSWDVPTVVPVPFEQVEENWTCILL
uniprot
proteins
ec_number
2.7.7.84
uniprot
proteins
function
FUNCTION: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response (PubMed:12396720, PubMed:34581622). In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation (PubMed:12396720, PubMed:34581622). Catalyzes the formation of 2'-5'-oligoadenylates (2-5A) from polymerization of ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation (PubMed:12396720, PubMed:34581622). Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication (PubMed:12396720, PubMed:34581622). Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L (PubMed:12396720, PubMed:34581622). Involved in intercellular immune signaling that limits local spread of RNA virus infection and protects against tumorigenesis (By similarity). Can generate high levels of 2',5'-oligoadenylates in transformed cells, targeting them to innate and adaptive immunesurveillance mechanisms (By similarity). {ECO:0000250|UniProtKB:P00973, ECO:0000269|PubMed:12396720, ECO:0000269|PubMed:34581622}.
uniprot
proteins
mass_dalton
42429
uniprot
proteins
post_translational_modification
PTM: C-terminal prenylated. {ECO:0000305|PubMed:34581622}.
uniprot
proteins
protein_family
2-5A synthase family
uniprot
proteins
pubmed
12396720
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15899864
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17024523
uniprot
proteins
pubmed
1709495
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21142819
uniprot
proteins
pubmed
2171206
uniprot
proteins
pubmed
22305621
uniprot
proteins
pubmed
27663720
uniprot
proteins
pubmed
34581622
uniprot
proteins
pubmed
3808949
uniprot
proteins
sequence_length
367
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15899864}. Mitochondrion {ECO:0000250|UniProtKB:P00973}. Nucleus {ECO:0000250|UniProtKB:P00973}. Microsome {ECO:0000250|UniProtKB:P00973}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P00973}. Note=Associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions. {ECO:0000250|UniProtKB:P00973}.
uniprot
proteins