PSMA1
entrez
5682
canonical
uniprot
P25786
canonical
ensembl
ENSG00000129084
resolver
ensp
ENSP00000379676
resolver
ensp
ENSP00000414359
resolver
ensp
ENSP00000688078
resolver
genesymbol
PSMA1
resolver
genesymbol_syn
HC2
resolver
genesymbol_syn
NU
resolver
genesymbol_syn
PROS30
resolver
genesymbol_syn
PSC2
resolver
hgnc
HGNC:9530
resolver
uniprot
A8K400
resolver
uniprot
B4E0X6
resolver
uniprot
Q53YE8
resolver
uniprot
Q9BRV9
resolver
uniprot_entry
B4E0X6_HUMAN
resolver
uniprot_entry
PSA1_HUMAN
resolver
uniprot_sec
A8K400
resolver
uniprot_sec
Q53YE8
resolver
uniprot_sec
Q9BRV9
resolver
amino_acid_sequence
MFRNQYDNDVTVWSPQGRIHQIEYAMEAVKQGSATVGLKSKTHAVLVALKRAQSELAAHQKKILHVDNHIGISIAGLTADARLLCNFMRQECLDSRFVFDRPLPVSRLVSLIGSKTQIPTQRYGRRPYGVGLLIAGYDDMGPHIFQTCPSANYFDCRAMSIGARSQSARTYLERHMSEFMECNLNELVKHGLRALRETLPAEQDLTTKNVSIGIVGKDLEFTIYDDDDVSPFLEGLEERPQRKAQPAQPADEPAEKADEPMEH
uniprot
proteins
function
FUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000269|PubMed:15244466, ECO:0000269|PubMed:27176742, ECO:0000269|PubMed:8610016}.
uniprot
proteins
mass_dalton
29556
uniprot
proteins
protein_family
Peptidase T1A family
uniprot
proteins
pubmed
12181345
uniprot
proteins
pubmed
1398136
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15244466
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16317774
uniprot
proteins
pubmed
17004105
uniprot
proteins
pubmed
17127214
uniprot
proteins
pubmed
17292860
uniprot
proteins
pubmed
17323924
uniprot
proteins
pubmed
1888762
uniprot
proteins
pubmed
2025653
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23495936
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25599644
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26133119
uniprot
proteins
pubmed
27176742
uniprot
proteins
pubmed
27342858
uniprot
proteins
pubmed
27428775
uniprot
proteins
pubmed
27493187
uniprot
proteins
pubmed
29804830
uniprot
proteins
pubmed
34711951
uniprot
proteins
pubmed
7811265
uniprot
proteins
pubmed
8610016
uniprot
proteins
sequence_length
263
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Nucleus {ECO:0000269|PubMed:12181345, ECO:0000269|PubMed:34711951}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000269|PubMed:34711951}.
uniprot
proteins