Slc51a
entrez
106407
canonical
uniprot
Q8R000
canonical
ensembl
ENSMUSG00000035699
resolver
ensp
ENSMUSP00000046286
resolver
enst
ENSMUST00000042042
resolver
genesymbol
Slc51a
resolver
genesymbol_syn
Osta
resolver
uniprot_entry
OSTA_MOUSE
resolver
amino_acid_sequence
MEPGRTHIKLDPRYTAELLELLETNYSISPACFSHPPTAAQLLRALGPVDIALTIILTFLTTGSVAIFLEDAVYLYKNTLCPIKKRTLIWSSSAPTVVSVFCCFGLWIPRALTLVEMAITSFYAVCFYLLMMVMVEGFGGKKAVLRTLKDTPMRVHTGPCCCCCPCCPPLILTRKKLQLLLLGPFQYAFFKITLSIVGLFLIPDGIYDPGEISEKSAALWINNLLAVSTLLALWSLAILFRQAKMHLGEQNMGSKFALFQVLVILTALQPAIFSILANSGQIACSPPYSSKIRSQVMNCHMLILETFLMTVLTRMYYRRKDDKVGYEACSLPDLDSALKA
uniprot
proteins
function
FUNCTION: Essential component of the Ost-alpha/Ost-beta complex, a heterotetramer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood (PubMed:15563450, PubMed:16317684, PubMed:17650074, PubMed:18292224, PubMed:22535958). The OST-alpha/OST-beta complex efficiently transports the major species of bile acids (taurocholate) (PubMed:16317684, PubMed:17650074, PubMed:18292224, PubMed:22535958). Taurine conjugates are transported more efficiently across the basolateral membrane than glycine-conjugated bile acids (PubMed:16317684). In the complex, SLC51A/OST-alpha adopts a G protein-coupled receptor fold and constitutes a bile acid recognition site (By similarity). Can also transport steroids such as estrone 3-sulfate and dehydroepiandrosterone 3-sulfate, therefore playing a role in the enterohepatic circulation of sterols (By similarity). Able to transport eicosanoids such as prostaglandin E2 (By similarity). {ECO:0000250|UniProtKB:Q86UW1, ECO:0000250|UniProtKB:Q90YM5, ECO:0000269|PubMed:15563450, ECO:0000269|PubMed:16317684, ECO:0000269|PubMed:17650074, ECO:0000269|PubMed:18292224, ECO:0000269|PubMed:22535958}.
uniprot
proteins
mass_dalton
37759
uniprot
proteins
post_translational_modification
PTM: Palmitoylation of the cysteine-rich loop is required to form a lateral substrate-binding groove for recognition of bile acids. {ECO:0000250|UniProtKB:Q86UW1}.; PTM: N-glycosylated. {ECO:0000305|PubMed:15563450}.
uniprot
proteins
protein_family
OST-alpha family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15563450
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16317684
uniprot
proteins
pubmed
16357058
uniprot
proteins
pubmed
16628672
uniprot
proteins
pubmed
17650074
uniprot
proteins
pubmed
18292224
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22535958
uniprot
proteins
pubmed
24381083
uniprot
proteins
pubmed
25626867
uniprot
proteins
sequence_length
340
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:15563450, ECO:0000269|PubMed:17650074, ECO:0000269|PubMed:22535958}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q86UW1}. Note=Transported from the endoplasmic reticulum to the plasma membrane upon interacting with SLC51B (PubMed:17650074). Mainly restricted to the lateral and basal membranes of ileal enterocytes (PubMed:17650074, PubMed:22535958). {ECO:0000269|PubMed:17650074, ECO:0000269|PubMed:22535958}.
uniprot
proteins
transmembrane_region
TRANSMEM 49..80; /note="Helical; Name=TM1"; /evidence="ECO:0000250|UniProtKB:Q86UW1"; TRANSMEM 83..108; /note="Helical; Name=TM2"; /evidence="ECO:0000250|UniProtKB:Q86UW1"; TRANSMEM 110..139; /note="Helical; Name=TM3"; /evidence="ECO:0000250|UniProtKB:Q86UW1"; TRANSMEM 174..202; /note="Helical; Name=TM4"; /evidence="ECO:0000250|UniProtKB:Q86UW1"; TRANSMEM 218..246; /note="Helical; Name=TM5"; /evidence="ECO:0000250|UniProtKB:Q86UW1"; TRANSMEM 249..278; /note="Helical; Name=TM6"; /evidence="ECO:0000250|UniProtKB:Q86UW1"; TRANSMEM 294..317; /note="Helical; Name=TM7"; /evidence="ECO:0000250|UniProtKB:Q86UW1
uniprot
proteins