Bst2
entrez
378947
canonical
uniprot
Q811A2
canonical
ensembl
ENSRNOG00055009156
resolver
ensembl
ENSRNOG00060011360
resolver
ensembl
ENSRNOG00065020615
resolver
ensp
ENSRNOP00055012414
resolver
ensp
ENSRNOP00060015043
resolver
ensp
ENSRNOP00065028071
resolver
enst
ENSRNOT00055015499
resolver
enst
ENSRNOT00060019223
resolver
enst
ENSRNOT00065034933
resolver
genesymbol
Bst2
resolver
genesymbol_syn
Damp1
resolver
uniprot_entry
BST2_RAT
resolver
amino_acid_sequence
MAPSFYHYLPVAMDERWEPKGWSIRRWWLVAAILVVLIGVVLVCLIVYFANAAHSEACKNGLRLQDECRNTTHLLKHQLTRAQDSLLQTEMQANSCNQTVMDLRDSLKKKVSQTQEQQARIKELENKIERLNQELENLRTQKEISTTVQVNSGGSVVVSSLLVLVAVLFLHF
uniprot
proteins
function
FUNCTION: IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), mouse mammary tumor virus (MMTV) and murine leukemia virus (MLV), filoviridae: ebola virus (EBOV), arenaviridae: lassa virus (LASV), and rhabdoviridae: vesicular stomatitis virus (VSV). Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection (By similarity). Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. {ECO:0000250, ECO:0000269|PubMed:19273615, ECO:0000269|PubMed:20702620}.
uniprot
proteins
mass_dalton
19674
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:12956872}.; PTM: The GPI anchor is essential for its antiviral activity. {ECO:0000250}.
uniprot
proteins
pubmed
12956872
uniprot
proteins
pubmed
19273615
uniprot
proteins
pubmed
20702620
uniprot
proteins
sequence_length
172
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network. Cell membrane; Single-pass type II membrane protein. Cell membrane; Lipid-anchor, GPI-anchor. Late endosome {ECO:0000250}. Membrane raft. Cytoplasm {ECO:0000250}. Apical cell membrane. Note=Shuttles between the cell membrane, where it is present predominantly in membrane/lipid rafts, and the trans-Golgi network. Forms a complex with MMP14 and localizes to the cytoplasm (By similarity). {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 27..47; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins