FEZ1
entrez
9638
canonical
uniprot
Q99689
canonical
ensembl
ENSG00000149557
resolver
ensp
ENSP00000278919
resolver
ensp
ENSP00000393425
resolver
ensp
ENSP00000533734
resolver
ensp
ENSP00000533744
resolver
genesymbol
FEZ1
resolver
hgnc
HGNC:3659
resolver
uniprot
O00679
resolver
uniprot
O00728
resolver
uniprot
Q6IBI7
resolver
uniprot_entry
FEZ1_HUMAN
resolver
uniprot_sec
O00679
resolver
uniprot_sec
O00728
resolver
uniprot_sec
Q6IBI7
resolver
amino_acid_sequence
MEAPLVSLDEEFEDLRPSCSEDPEEKPQCFYGSSPHHLEDPSLSELENFSSEIISFKSMEDLVNEFDEKLNVCFRNYNAKTENLAPVKNQLQIQEEEETLQDEEVWDALTDNYIPSLSEDWRDPNIEALNGNCSDTEIHEKEEEEFNEKSENDSGINEEPLLTADQVIEEIEEMMQNSPDPEEEEEVLEEEDGGETSSQADSVLLQEMQALTQTFNNNWSYEGLRHMSGSELTELLDQVEGAIRDFSEELVQQLARRDELEFEKEVKNSFITVLIEVQNKQKEQRELMKKRRKEKGLSLQSSRIEKGNQMPLKRFSMEGISNILQSGIRQTFGSSGTDKQYLNTVIPYEKKASPPSVEDLQMLTNILFAMKEDNEKVPTLLTDYILKVLCPT
uniprot
proteins
function
FUNCTION: May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules. {ECO:0000269|PubMed:20812761, ECO:0000269|PubMed:22354037}.
uniprot
proteins
mass_dalton
45119
uniprot
proteins
mutagenesis
MUTAGEN 248; /note="E->A: No effect on SCOC--binding."; /evidence="ECO:0000269|PubMed:22354037"; MUTAGEN 254; /note="L->P: Loss of SCOC-binding. No effect on ULK1-binding."; /evidence="ECO:0000269|PubMed:22354037"; MUTAGEN 260; /note="L->P: Loss of SCOC-binding. No effect on ULK1-binding."; /evidence="ECO:0000269|PubMed:22354037"; MUTAGEN 264; /note="K->A: No effect on SCOC-binding."; /evidence="ECO:0000269|PubMed:22354037
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by protein kinase C zeta; which enhances interaction with UBE4B and polyubiquitination. {ECO:0000269|PubMed:15466860}.; PTM: Polyubiquitinated in a UBE4B-dependent manner; which does not lead to proteasomal degradation and may be important for neurogenic activity. Polyubiquitin linkage seems to be mainly through Lys-26. {ECO:0000269|PubMed:15466860}.
uniprot
proteins
protein_family
Zygin family
uniprot
proteins
pubmed
15466860
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16484223
uniprot
proteins
pubmed
18439996
uniprot
proteins
pubmed
20812761
uniprot
proteins
pubmed
22354037
uniprot
proteins
pubmed
24098481
uniprot
proteins
pubmed
9096408
uniprot
proteins
sequence_length
392
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18439996}. Cell membrane {ECO:0000250}. Note=Colocalizes with both, alpha- and gamma-tubulin. Translocated from the plasma membrane to the cytoplasm by activation of the PKC zeta (By similarity). {ECO:0000250}.
uniprot
proteins