CD72
entrez
971
canonical
uniprot
P21854
canonical
ensembl
ENSG00000137101
resolver
ensp
ENSP00000259633
resolver
ensp
ENSP00000367688
resolver
enst
ENST00000259633
resolver
genesymbol
CD72
resolver
hgnc
HGNC:1696
resolver
uniprot
Q5TLG3
resolver
uniprot_entry
CD72_HUMAN
resolver
uniprot_entry
Q5TLG3_HUMAN
resolver
amino_acid_sequence
MAEAITYADLRFVKAPLKKSISSRLGQDPGADDDGEITYENVQVPAVLGVPSSLASSVLGDKAAVKSEQPTASWRAVTSPAVGRILPCRTTCLRYLLLGLLLTCLLLGVTAICLGVRYLQVSQQLQQTNRVLEVTNSSLRQQLRLKITQLGQSAEDLQGSRRELAQSQEALQVEQRAHQAAEGQLQACQADRQKTKETLQSEEQQRRALEQKLSNMENRLKPFFTCGSADTCCPSGWIMHQKSCFYISLTSKNWQESQKQCETLSSKLATFSEIYPQSHSYYFLNSLLPNGGSGNSYWTGLSSNKDWKLTDDTQRTRTYAQSSKCNKVHKTWSWWTLESESCRSSLPYICEMTAFRFPD
uniprot
proteins
function
FUNCTION: Co-receptor of B cell receptor (BCR) that plays both positive and negative roles on B-cell functions. Recognizes the Sm/ribonucleoprotein (RNP) self-antigen ligand, and coligation of CD72 and BCR inhibits BCR signaling. Mechanistically, ligand binding leads to the recruitment of PTPN6/SHP-1 to the BCR complex which is inhibitory to BCR signaling. Also acts as a ligand for CD5 and thereby plays a critical role in maintaining regulatory T and B-cell homeostasis. {ECO:0000250|UniProtKB:P21855}.
uniprot
proteins
mass_dalton
40220
uniprot
proteins
post_translational_modification
PTM: Phosphorylated upon engagement of the B-cell receptor, probably by LYN or SYK. Phosphorylation at Tyr-7 is important for interaction with PTPN6/SHP-1. {ECO:0000250|UniProtKB:P21855}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2141045
uniprot
proteins
sequence_length
359
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 96..116; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins