NALF1
entrez
728215
canonical
uniprot
B1AL88
canonical
ensembl
ENSG00000204442
resolver
ensp
ENSP00000365080
resolver
enst
ENST00000375915
resolver
genesymbol
NALF1
resolver
genesymbol_syn
FAM155A
resolver
genesymbol_syn
NLF-1
resolver
hgnc
HGNC:33877
resolver
uniprot
B2RUV1
resolver
uniprot
B7Z334
resolver
uniprot_entry
NALF1_HUMAN
resolver
uniprot_sec
B2RUV1
resolver
uniprot_sec
B7Z334
resolver
amino_acid_sequence
MTRGAWMCRQYDDGLKIWLAAPRENEKPFIDSERAQKWRLSLASLLFFTVLLSDHLWFCAEAKLTRARDKEHQQQQRQQQQQQQQQRQRQQQQQQRRQQEPSWPALLASMGESSPAAQAHRLLSASSSPTLPPSPGDGGGGGGKGNRGKDDRGKALFLGNSAKPVWRLETCYPQGASSGQCFTVENADAVCARNWSRGAAGGDGQEVRSKHPTPLWNLSDFYLSFCNSYTLWELFSGLSSPNTLNCSLDVVLKEGGEMTTCRQCVEAYQDYDHHAQEKYEEFESVLHKYLQSEEYSVKSCPEDCKIVYKAWLCSQYFEVTQFNCRKTIPCKQYCLEVQTRCPFILPDNDEVIYGGLSSFICTGLYETFLTNDEPECCDVRREEKSNNPSKGTVEKSGSCHRTSLTVSSATRLCNSRLKLCVLVLILLHTVLTASAAQNTAGLSFGGINTLEENSTNEE
uniprot
proteins
function
FUNCTION: Auxilary subunit component of the NALCN channelosome complex, which regulates the resting membrane potential by depolarizing sodium leak currents (PubMed:32494638, PubMed:33203861, PubMed:35387979, PubMed:34929720). The NALCN channelosome complex is a voltage-gated ion channel responsible for the resting Na(+) permeability that controls neuronal excitability (PubMed:35387979, PubMed:34929720). The NALCN channelosome is constitutively active and conducts monovalent cations but is blocked by physiological concentrations of extracellular divalent cations (PubMed:32494638). {ECO:0000269|PubMed:32494638, ECO:0000269|PubMed:33203861, ECO:0000269|PubMed:34929720, ECO:0000269|PubMed:35387979}.
uniprot
proteins
mass_dalton
51493
uniprot
proteins
protein_family
NALF family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
32494638
uniprot
proteins
pubmed
32698188
uniprot
proteins
pubmed
33203861
uniprot
proteins
pubmed
34929720
uniprot
proteins
pubmed
35387979
uniprot
proteins
sequence_length
458
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:32494638}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..60; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 417..437; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins