RGS7
entrez
6000
canonical
uniprot
P49802
canonical
ensembl
ENSG00000182901
resolver
ensp
ENSP00000341242
resolver
ensp
ENSP00000355521
resolver
ensp
ENSP00000355522
resolver
ensp
ENSP00000355523
resolver
ensp
ENSP00000404399
resolver
ensp
ENSP00000508919
resolver
ensp
ENSP00000509046
resolver
ensp
ENSP00000509318
resolver
ensp
ENSP00000509835
resolver
ensp
ENSP00000510103
resolver
ensp
ENSP00000510116
resolver
ensp
ENSP00000510187
resolver
ensp
ENSP00000510372
resolver
ensp
ENSP00000510458
resolver
ensp
ENSP00000510735
resolver
enst
ENST00000685936
resolver
enst
ENST00000687448
resolver
enst
ENST00000688703
resolver
enst
ENST00000689115
resolver
enst
ENST00000689602
resolver
enst
ENST00000690019
resolver
enst
ENST00000690614
resolver
enst
ENST00000691485
resolver
enst
ENST00000691989
resolver
enst
ENST00000692410
resolver
genesymbol
RGS7
resolver
hgnc
HGNC:10003
resolver
uniprot
A0A8I5KR55
resolver
uniprot
A0A8I5KUA7
resolver
uniprot
A0A8I5KXW5
resolver
uniprot
A0A8I5KZ50
resolver
uniprot
A0A8I5QJU0
resolver
uniprot
B7Z257
resolver
uniprot
Q5T3H4
resolver
uniprot
Q8TD66
resolver
uniprot
Q8TD67
resolver
uniprot
Q8WW09
resolver
uniprot
Q9UNU7
resolver
uniprot
Q9Y6B9
resolver
uniprot_entry
A0A8I5KR55_HUMAN
resolver
uniprot_entry
A0A8I5KUA7_HUMAN
resolver
uniprot_entry
A0A8I5KXW5_HUMAN
resolver
uniprot_entry
A0A8I5KZ50_HUMAN
resolver
uniprot_entry
A0A8I5QJU0_HUMAN
resolver
uniprot_entry
B7Z257_HUMAN
resolver
uniprot_entry
RGS7_HUMAN
resolver
uniprot_sec
Q5T3H4
resolver
uniprot_sec
Q8TD66
resolver
uniprot_sec
Q8TD67
resolver
uniprot_sec
Q8WW09
resolver
uniprot_sec
Q9UNU7
resolver
uniprot_sec
Q9Y6B9
resolver
amino_acid_sequence
MAQGNNYGQTSNGVADESPNMLVYRKMEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFWPSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKSGNSMDRRTSFEKFAQNVGRNIPIFPCHKNCTPTLRASTNLL
uniprot
proteins
function
FUNCTION: GTPase activator component of the RGS7-GNB5 complex that regulates G protein-coupled receptor signaling cascades (PubMed:10521509, PubMed:10862767, PubMed:31189666). The RGS7-GNB5 complex acts as an inhibitor signal transduction by promoting the GTPase activity of G protein alpha subunits, such as GNAO1, thereby driving them into their inactive GDP-bound form (PubMed:10521509, PubMed:10862767). May play a role in synaptic vesicle exocytosis (Probable) (PubMed:12659861). Glycine-dependent regulation of the RGS7-GNB5 complex by GPR158 affects mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex (By similarity). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling (PubMed:15897264). {ECO:0000250|UniProtKB:O54829, ECO:0000269|PubMed:10521509, ECO:0000269|PubMed:10862767, ECO:0000269|PubMed:15897264, ECO:0000269|PubMed:31189666, ECO:0000305|PubMed:12659861}.
uniprot
proteins
mass_dalton
57668
uniprot
proteins
mutagenesis
MUTAGEN 306; /note="W->F: Diminishes interaction with GNB5."; /evidence="ECO:0000269|PubMed:10339615
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. {ECO:0000250|UniProtKB:O46470}.; PTM: Ubiquitinated, leading to rapid proteasomal degradation. {ECO:0000269|PubMed:10339594}.; PTM: Phosphorylation and subsequent interaction with 14-3-3 proteins inhibits GAP activity. {ECO:0000269|PubMed:10862767}.
uniprot
proteins
pubmed
10339594
uniprot
proteins
pubmed
10339615
uniprot
proteins
pubmed
10521509
uniprot
proteins
pubmed
10862767
uniprot
proteins
pubmed
12659861
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15897264
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18434541
uniprot
proteins
pubmed
31189666
uniprot
proteins
pubmed
34793198
uniprot
proteins
pubmed
34815401
uniprot
proteins
pubmed
8548815
uniprot
proteins
sequence_length
495
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10521509}. Cytoplasm {ECO:0000269|PubMed:10339594, ECO:0000269|PubMed:15897264}. Cell membrane {ECO:0000269|PubMed:10339594, ECO:0000269|PubMed:15897264}. Membrane {ECO:0000269|PubMed:10521509}; Peripheral membrane protein {ECO:0000269|PubMed:10521509}; Cytoplasmic side {ECO:0000305}. Note=Interaction with PKD1 promotes location at the cell membrane (PubMed:10339594). Interaction with RGS7BP promotes location at the cell membrane (PubMed:15897264). {ECO:0000269|PubMed:10339594, ECO:0000269|PubMed:15897264}.
uniprot
proteins