Hkdc1
entrez
216019
canonical
uniprot
Q91W97
canonical
ensembl
ENSMUSG00000020080
resolver
ensp
ENSMUSP00000020277
resolver
enst
ENSMUST00000020277
resolver
genesymbol
Hkdc1
resolver
uniprot
Q3UKJ9
resolver
uniprot_entry
HKDC1_MOUSE
resolver
uniprot_sec
Q3UKJ9
resolver
amino_acid_sequence
MFAVHLVAFYFTKLKEDQIKKVDRFLYHMRLSDETLVDIMARFQAEMEKGLGKDTNPTASVKMLPTFVRAIPDGSENGEFLSLDLGGSKFRVLKVQVSQEGQQNVQMESQFYPMPNEITRGNGTELFDYVADCLADFMKTKNLTHKKLPLGFTFSFPCRQNKLEEGVLLSWTKKFKARGVQDTDVVNRLATAMKKHKDLDVDILALVNDTVGTMMTCAYDDPNCEVGVIIGTGTNACYMEDMSNIDLVEGDEGRMCINTEWGAFGDDGALEDIRTEFDRELDLGSLNPGKQLFEKMISGLYMGELVRLILLKMAKVGLLFGGAKSSALHTKGKIETQHVAAMEMSKEGLANTREILVDLGLEPSESDCIAVQHVCTIVSFRSANLCAAALATILTRLRENKKLARLRTTVGMDGTLYKTHPQYPKRLHKVVRRLVPNCDVRFLLSESGSTKGAAMVTAVASRVQAQRKQIDKVLALFQLTREQLLGVRDKMRAELEYGLKKKTHSLATVKMLPTYVYGMPDGTEKGKFLALDLGGTNFRVLLVKIRRRSVRMYNKIFAIPLEIMQGTGEELFDHIVQCIADFLDYMGLKGAQLPLGFTFSFPCRQTCIDKGTLVGWTKGFKATDCEGEDVVDMLREAIKRRNEFDLDIVAIVNDTVGTMMTCGYEDPRCEIGLIAGTGSNVCYMEEMRNIELVDGDEGRMCVNTEWGGFGDNGCIDDIRTQYDKEVDEGSLNAGKQRYEKMTSGMYLGEIVRRILIDLTRQGLLFRGQISERLRTRGIFETKFLSQIESDRLALLQVRRILQQLGLDSTCEDSIVVKEVCGAVSRRAAQMCGAGMAAIVEKRREDQGLQHFKVTVGVDGTLYKLHPHFSRILQETVKELAPQCDVTFMLSEDGSGKGAALITAVAKRLQQPRKDI
uniprot
proteins
ec_number
2.7.1.1
uniprot
proteins
function
FUNCTION: Catalyzes the phosphorylation of hexose to hexose 6-phosphate, although at very low level compared to other hexokinases (By similarity). Has low glucose phosphorylating activity compared to other hexokinases (By similarity). Involved in glucose homeostasis and hepatic lipid accumulation (PubMed:30543855). Required to maintain whole-body glucose homeostasis during pregnancy; however additional evidence is required to confirm this role (PubMed:25648650, PubMed:27459389). {ECO:0000250|UniProtKB:Q2TB90, ECO:0000269|PubMed:25648650, ECO:0000269|PubMed:27459389, ECO:0000269|PubMed:30543855}.
uniprot
proteins
mass_dalton
102259
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate metabolism; hexose metabolism. {ECO:0000250|UniProtKB:Q2TB90}.; PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4. {ECO:0000250|UniProtKB:Q2TB90}.
uniprot
proteins
protein_family
Hexokinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
25648650
uniprot
proteins
pubmed
27459389
uniprot
proteins
pubmed
30085091
uniprot
proteins
pubmed
30543855
uniprot
proteins
sequence_length
915
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q2TB90}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q2TB90}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q2TB90}. Photoreceptor inner segment {ECO:0000269|PubMed:30085091}. Note=The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrion. {ECO:0000250|UniProtKB:Q2TB90}.
uniprot
proteins