Cct4
entrez
29374
canonical
uniprot
Q7TPB1
canonical
ensembl
ENSRNOG00000009642
resolver
ensembl
ENSRNOG00055007931
resolver
ensembl
ENSRNOG00060014242
resolver
ensembl
ENSRNOG00065005597
resolver
ensp
ENSRNOP00000012847
resolver
ensp
ENSRNOP00055010714
resolver
ensp
ENSRNOP00060019469
resolver
ensp
ENSRNOP00065005840
resolver
enst
ENSRNOT00000012847
resolver
enst
ENSRNOT00055013361
resolver
enst
ENSRNOT00060024388
resolver
enst
ENSRNOT00065008312
resolver
genesymbol
Cct4
resolver
uniprot_entry
TCPD_RAT
resolver
amino_acid_sequence
MPENVASRSGPPAAGPGNRGKGAYQDRDKPAQIRFSNISAAKAVADAIRTSLGPKGMDKMIQDGKGDVTITNDGATILKQMQVLHPAARMLVELSKAQDIEAGDGTTSVVIIAGSLLDSCTKLLQKGIHPTIISESFQKALEKGLEILTDMSRPVQLSDRETLLNSATTSLNSKVVSQYSSLLSPMSVNAVMKVIDPATATSVDLRDIKIVKKLGGTIDDCELVEGLVLTQKVANSGITRVEKAKIGLIQFCLSAPKTDMDNQIVVSDYAQMDRVLREERAYILNLVKQIKKTGCNVLLIQKSILRDALSDLALHFLNKMKIMVVKDIEREDIEFICKTIGTKPVAHIDQFTPDMLGSAELAEEVSLNGSGKLFKITGCTSPGKTVTIVVRGSNKLVIEEAERSIHDALCVIRCLVKKRALIAGGGAPEIELALRLTEYSRTLSGMESYCVRAFADAMEVIPSTLAENAGLNPISTVTELRNRHAQGEKTTGINVRKGGISNILEEMVVQPLLVSVSALTLATETVRSILKIDDVVNTR
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Cct4 are a cause of an early onset sensory neuropathy knowm as mutilated foot (mf). The main clinical features include ataxia, insensitivity to pain and foot ulceration. The pathological features include a severe reduction in the number of sensory ganglia and fibers. {ECO:0000269|PubMed:12874111}.
uniprot
proteins
ec_number
3.6.1.-
uniprot
proteins
function
FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. {ECO:0000250|UniProtKB:P50991}.
uniprot
proteins
mass_dalton
58099
uniprot
proteins
protein_family
TCP-1 chaperonin family
uniprot
proteins
pubmed
12874111
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
539
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P50991}. Melanosome {ECO:0000250|UniProtKB:P50991}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P50991}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:P80315}.
uniprot
proteins