Mrpl12
entrez
56282
canonical
uniprot
Q9DB15
canonical
ensembl
ENSMUSG00000039640
resolver
ensp
ENSMUSP00000044417
resolver
enst
ENSMUST00000043627
resolver
genesymbol
Mrpl12
resolver
genesymbol_syn
Rpml12
resolver
uniprot
B1ATZ3
resolver
uniprot
Q3TKJ3
resolver
uniprot
Q99JS8
resolver
uniprot_entry
RM12_MOUSE
resolver
uniprot_sec
B1ATZ3
resolver
uniprot_sec
Q3TKJ3
resolver
uniprot_sec
Q99JS8
resolver
amino_acid_sequence
MLPVAASRCLWGPRLGLRGAALRLARQQMPSVCAARQLRSSSHRRSEALAGAPLDNAPKEYPPKIQQLVQDIASLTLLEISDLNELLKKTLKIQDVGLMPMGGMVPGPVSAAAPASEAAEEEDVPKQKERTHFTVRLTEAKPVDKVKLIKEIKNYVQGINLVQAKKLVESLPQEIKANVAKAEAEKIKAALEAVGGTVVLE
uniprot
proteins
function
FUNCTION: As a component of the mitochondrial large ribosomal subunit, plays a role in mitochondrial translation. When present in mitochondria as a free protein not associated with the ribosome, associates with mitochondrial RNA polymerase POLRMT to activate transcription. Required for POLRMT stability. {ECO:0000250|UniProtKB:P52815}.
uniprot
proteins
mass_dalton
21708
uniprot
proteins
post_translational_modification
PTM: Two mature forms are produced by differential two-step proteolytic cleavage. Cleaved by the mitochondrial processing protease to produce the long mature form and subsequently by the mitochondrial intermediate protease to produce the short mature form. {ECO:0000250|UniProtKB:P52815}.; PTM: In the presence of CUL3, undergoes 'Lys-63'-linked ubiquitination at Lys-153 which results in proteasomal degradation. {ECO:0000250|UniProtKB:P52815}.
uniprot
proteins
protein_family
Bacterial ribosomal protein bL12 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
201
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:P52815}.
uniprot
proteins