SNX33
entrez
257364
canonical
uniprot
Q8WV41
canonical
ensembl
ENSG00000173548
resolver
ensp
ENSP00000311427
resolver
enst
ENST00000308527
resolver
genesymbol
SNX33
resolver
genesymbol_syn
SH3PX3
resolver
genesymbol_syn
SH3PXD3C
resolver
genesymbol_syn
SNX30
resolver
hgnc
HGNC:28468
resolver
uniprot
B1NM17
resolver
uniprot_entry
SNX33_HUMAN
resolver
uniprot_sec
B1NM17
resolver
amino_acid_sequence
MALKGRALYDFHSENKEEISIQQDEDLVIFSETSLDGWLQGQNSRGETGLFPASYVEIVRSGISTNHADYSSSPAGSPGAQVSLYNSPSVASPARSGGGSGFLSNQGSFEEDDDDDWDDWDDGCTVVEEPRAGGLGTNGHPPLNLSYPGAYPSQHMAFRPKPPLERQDSLASAKRGSVVGRNLNRFSCFVRSGVEAFILGDVPMMAKIAETYSIEMGPRGPQWKANPHPFACSVEDPTKQTKFKGIKSYISYKLTPTHAASPVYRRYKHFDWLYNRLLHKFTVISVPHLPEKQATGRFEEDFIEKRKRRLILWMDHMTSHPVLSQYEGFQHFLSCLDDKQWKMGKRRAEKDEMVGASFLLTFQIPTEHQDLQDVEDRVDTFKAFSKKMDDSVLQLSTVASELVRKHVGGFRKEFQKLGSAFQAISHSFQMDPPFCSEALNSAISHTGRTYEAIGEMFAEQPKNDLFQMLDTLSLYQGLLSNFPDIIHLQKGAFAKVKESQRMSDEGRMVQDEADGIRRRCRVVGFALQAEMNHFHQRRELDFKHMMQNYLRQQILFYQRVGQQLEKTLRMYDNL
uniprot
proteins
function
FUNCTION: Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes. {ECO:0000269|PubMed:18353773, ECO:0000269|PubMed:18419754, ECO:0000269|PubMed:19487689, ECO:0000269|PubMed:20964629, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350}.
uniprot
proteins
mass_dalton
65265
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000269|PubMed:18353773}.
uniprot
proteins
protein_family
Sorting nexin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16374509
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18353773
uniprot
proteins
pubmed
18419754
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19487689
uniprot
proteins
pubmed
19718658
uniprot
proteins
pubmed
19807924
uniprot
proteins
pubmed
20964629
uniprot
proteins
pubmed
21048941
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22718350
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
574
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note=Primarily cytosolic, but a minor proportion is membrane-bound (PubMed:18353773). Not associated with membranes (PubMed:21048941). {ECO:0000269|PubMed:18353773, ECO:0000269|PubMed:21048941}.
uniprot
proteins