Entpd1
entrez
12495
canonical
uniprot
P55772
canonical
ensembl
ENSMUSG00000048120
resolver
ensp
ENSMUSP00000107850
resolver
ensp
ENSMUSP00000116285
resolver
enst
ENSMUST00000112231
resolver
enst
ENSMUST00000134063
resolver
genesymbol
Entpd1
resolver
genesymbol_syn
Cd39
resolver
uniprot
F6QGD9
resolver
uniprot
Q544U5
resolver
uniprot
Q8CDV7
resolver
uniprot_entry
ENTP1_MOUSE
resolver
uniprot_entry
F6QGD9_MOUSE
resolver
uniprot_entry
Q544U5_MOUSE
resolver
uniprot_entry
Q8CDV7_MOUSE
resolver
amino_acid_sequence
MEDIKDSKVKRFCSKNILIILGFTSILAVIALIAVGLTQNKPLPENVKYGIVLDAGSSHTNLYIYKWPAEKENDTGVVQQLEECQVKGPGISKYAQKTDEIGAYLAECMELSTELIPTSKHHQTPVYLGATAGMRLLRMESEQSADEVLAAVSTSLKSYPFDFQGAKIITGQEEGAYGWITINYLLGRFTQEQSWLSLISDSQKQETFGALDLGGASTQITFVPQNSTIESPENSLQFRLYGEDYTVYTHSFLCYGKDQALWQKLAKDIQVSSGGVLKDPCFNPGYEKVVNVSELYGTPCTKRFEKKLPFDQFRIQGTGDYEQCHQSILELFNNSHCPYSQCAFNGVFLPPLHGSFGAFSAFYFVMDFFKKVAKNSVISQEKMTEITKNFCSKSWEETKTSYPSVKEKYLSEYCFSGAYILSLLQGYNFTDSSWEQIHFMGKIKDSNAGWTLGYMLNLTNMIPAEQPLSPPLPHSTYIGLMVLFSLLLVAVAITGLFIYSKPSYFWKEAV
uniprot
proteins
ec_number
3.6.1.5
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of nucleoside triphosphates (NTPs) and diphosphates (NDPs) (By similarity). The enzyme sequentially removes phosphate groups in two successive steps, converting NTPs to nucleoside monophosphates (NMPs) via NDP intermediates (By similarity). This activity contributes to the regulation of extracellular levels of nucleotides (By similarity). By hydrolyzing proinflammatory ATP and platelet-activating ADP to AMP, it blocks platelet aggregation and supports blood flow (By similarity). {ECO:0000250|UniProtKB:P49961}.
uniprot
proteins
mass_dalton
57205
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:P97687}.; PTM: The N-terminus is blocked. {ECO:0000250|UniProtKB:P49961}.; PTM: Palmitoylated on Cys-13; which is required for caveola targeting. {ECO:0000250|UniProtKB:P49961}.
uniprot
proteins
protein_family
GDA1/CD39 NTPase family
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7930580
uniprot
proteins
pubmed
9730622
uniprot
proteins
sequence_length
510
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P49961}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P49961}. Membrane, caveola {ECO:0000250|UniProtKB:P49961}.
uniprot
proteins
transmembrane_region
TRANSMEM 17..37; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 479..499; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins