Cdc25b
entrez
171103
canonical
uniprot
P48966
canonical
ensembl
ENSRNOG00000021248
resolver
ensp
ENSRNOP00000088213
resolver
ensp
ENSRNOP00000091343
resolver
ensp
ENSRNOP00000106275
resolver
enst
ENSRNOT00000101513
resolver
enst
ENSRNOT00000122290
resolver
genesymbol
Cdc25b
resolver
uniprot
A0A8I6A7K8
resolver
uniprot
A0ABK0LKL5
resolver
uniprot_entry
A0A8I6A7K8_RAT
resolver
uniprot_entry
A0ABK0LKL5_RAT
resolver
uniprot_entry
MPIP2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Stimulated by B-type cyclins. {ECO:0000250|UniProtKB:P30305}.
uniprot
proteins
amino_acid_sequence
MEVPPQKSAPGSALSTARVLGGIQRPRHLSGFGFGSDGLLGSPERAASSSPVTTLTQTMYNLAGLGSETPKTQVGSLSFQNRLTDLSLSRRTSECSLSSESSESSDAGLCMDSPSPMDPQTAERTFEQAIQAASRVIQKMQFTIKASVFASEAAGHSPVLQNITNSQALDSWEKDEAGYRAASSPGEDKENDGYIFKMPQKLPHSSSARALAEWASRREAFTQRPSSAPDLMCLTTDGKMDVEEASPVAQSSSLTPVERACEEDDGFVDILESDLKDDDMVPAGMENLISAPLVKKLDKEEEQDLIMFSKCQRLFRSPSMPCSVIRPILKRLERPHDRDVPVLSKRRKSGTPLEEQQLEEPKARVFRSKSLCHEIESILDSDHRGLIGDYSKAFLLQTVDGKHQDLKYISPETMVALLTGKFSNIVEKFVIVDCRYPYEYEGGHIKNAVNLPLEPDAETFLLKHPITPCNLDKRIILIFHCEFSSERGPRMCRFIRERDRAANDYPSLYYPEMYILKGGYKEFFPQHPNFCEPQDYRPMNHAAFRDELRNFRLKTRSWAGERSTTQLCSRLQDQ
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression. Directly dephosphorylates CDK1 and stimulates its kinase activity. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. The three isoforms seem to have a different level of activity. {ECO:0000250|UniProtKB:P30305}.
uniprot
proteins
mass_dalton
64287
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by BRSK1 in vitro. Phosphorylated by CHEK1, which inhibits the activity of this protein. Phosphorylation at Ser-349 by AURKA might locally participate in the control of the onset of mitosis. Phosphorylation by MELK at Ser-166 promotes localization to the centrosome and the spindle poles during mitosis. Phosphorylation at Ser-319 and Ser-370 by MAPK14 is required for binding to 14-3-3 proteins (By similarity). {ECO:0000250|UniProtKB:P30305}.
uniprot
proteins
protein_family
MPI phosphatase family
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8156993
uniprot
proteins
sequence_length
574
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P30305}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:P30305}.
uniprot
proteins