Mapre1
entrez
13589
canonical
uniprot
Q61166
canonical
ensembl
ENSMUSG00000027479
resolver
ensp
ENSMUSP00000028981
resolver
ensp
ENSMUSP00000189596
resolver
ensp
ENSMUSP00000189602
resolver
enst
ENSMUST00000028981
resolver
genesymbol
Mapre1
resolver
uniprot
Q3U4H0
resolver
uniprot
Q7TN34
resolver
uniprot_entry
MARE1_MOUSE
resolver
uniprot_entry
Q3U4H0_MOUSE
resolver
uniprot_sec
Q7TN34
resolver
amino_acid_sequence
MAVNVYSTSVTSDNLSRHDMLAWINESLQLNLTKIEQLCSGAAYCQFMDMLFPGSIALKKVKFQAKLEHEYIQNFKILQAGFKRMGVDKIIPVDKLVKGKFQDNFEFVQWFKKFFDANYDGKEYDPVAARQGQETAVAPSLVAPALSKPKKPLGSSTAAPQRPIATQRTTAAPKAGPGMVRKNPGVGNGDDEAAELMQQVKVLKLTVEDLEKERDFYFGKLRNIELICQENEGENDPVLQRIVDILYATDEGFVIPDEGGPQEEQEEY
uniprot
proteins
function
FUNCTION: Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Recruits other +TIP proteins to microtubules by binding to a conserved Ser-X-Leu-Pro (SXLP) motif in their polypeptide chains. Promotes cytoplasmic microtubule nucleation and elongation. Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation. Assists chromosome alignment in metaphase by recruiting the SKA complex to the spindle and stabilizing its interactions with microtubule bundles (K-fibers). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement. Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules. Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (By similarity). Functions downstream of Rho GTPases and DIAPH1 in stable microtubule formation (PubMed:15311282). Promotes microtubule-mediated GJA1/CX43 trafficking to cell membranes via its interaction with DSP, thereby facilitating gap junction intracellular communication (By similarity). May play a role in cell migration (PubMed:15311282). {ECO:0000250|UniProtKB:Q15691, ECO:0000269|PubMed:15311282}.
uniprot
proteins
mass_dalton
30016
uniprot
proteins
mutagenesis
MUTAGEN 211..215; /note="EKERD->KKERK: Loss of interaction with APC and DCTN1."; /evidence="ECO:0000269|PubMed:15311282"; MUTAGEN 211..213; /note="EKE->AKA: Partial loss of interaction with APC."; /evidence="ECO:0000269|PubMed:15311282"; MUTAGEN 220..222; /note="KLR->ALA: Loss of interaction with APC and DCTN1."; /evidence="ECO:0000269|PubMed:15311282
uniprot
proteins
post_translational_modification
PTM: Acetylation at Lys-220 by KAT2B/PCAF promotes dynamic kinetochore-microtubule interactions in early mitosis. {ECO:0000250|UniProtKB:Q15691}.; PTM: Crotonylated by KAT5 during mitosis, promoting astral microtubule plasticity and dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation, thereby ensuring accurate spindle positioning in mitosis. Decrotonylated by HDAC3. {ECO:0000250|UniProtKB:Q15691}.
uniprot
proteins
protein_family
MAPRE family
uniprot
proteins
pubmed
15311282
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18854161
uniprot
proteins
pubmed
19553473
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21357749
uniprot
proteins
pubmed
21646404
uniprot
proteins
pubmed
23055941
uniprot
proteins
pubmed
24706950
uniprot
proteins
pubmed
30787442
uniprot
proteins
sequence_length
268
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15311282, ECO:0000269|PubMed:21357749, ECO:0000269|PubMed:24706950}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q15691}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q15691}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q15691}. Cell membrane {ECO:0000250|UniProtKB:Q15691}. Note=Associated with the microtubule network at the growing distal tip of microtubules (PubMed:21357749). In addition to localizing to microtubule plus-ends, also exhibits some localization along the length of the microtubules (By similarity). Also enriched at the centrosome (By similarity). {ECO:0000250|UniProtKB:Q15691, ECO:0000269|PubMed:21357749}.
uniprot
proteins