Gria1
entrez
14799
canonical
uniprot
P23818
canonical
ensembl
ENSMUSG00000020524
resolver
ensp
ENSMUSP00000044494
resolver
ensp
ENSMUSP00000091731
resolver
ensp
ENSMUSP00000117746
resolver
enst
ENSMUST00000036315
resolver
enst
ENSMUST00000094179
resolver
enst
ENSMUST00000151045
resolver
genesymbol
Gria1
resolver
genesymbol_syn
Glur1
resolver
uniprot
F6YNQ1
resolver
uniprot
F6YQG8
resolver
uniprot
Q7TNB5
resolver
uniprot_entry
F6YNQ1_MOUSE
resolver
uniprot_entry
F6YQG8_MOUSE
resolver
uniprot_entry
GRIA1_MOUSE
resolver
uniprot_entry
Q7TNB5_MOUSE
resolver
amino_acid_sequence
MPYIFAFFCTGFLGAVVGANFPNNIQIGGLFPNQQSQEHAAFRFALSQLTEPPKLLPQIDIVNISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQFVLQLRPELQEALISIIDHYKWQTFVYIYDADRGLSVLQRVLDTAAEKNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPARIMQQWRTSDARDHTRVDWKRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRGPVNLAVLKLSEQGVLDKLKSKWWYDKGECGSKDSGSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMKGFCLIPQQSINEAIRTSTLPRNSGAGASGGSGSGENGRVVSQDFPKSMQSIPCMSHSSGMPLGATGL
uniprot
proteins
function
FUNCTION: Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (PubMed:1699805). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium. The receptor then desensitizes rapidly and enters in a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG2 or CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate. Calcium (Ca(2+)) permeability depends on subunits composition and, heteromeric channels containing edited GRIA2 subunit are calcium-impermeable. Also permeable to other divalents cations such as strontium(2+) and magnesium(2+) and monovalent cations such as potassium(1+) and lithium(1+) (By similarity). {ECO:0000250|UniProtKB:P19490, ECO:0000269|PubMed:1699805}.
uniprot
proteins
mass_dalton
101569
uniprot
proteins
mutagenesis
MUTAGEN 905..907; /note="TGL->AGA: Almost abolishes interaction with SHANK3."; /evidence="ECO:0000269|PubMed:16606358
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-645. Phosphorylated at Ser-710 by PKC. Phosphorylated at Ser-849 by PKC, PKA and CAMK2. Phosphorylated at Ser-863 by PKC, PKA and PRKG2 (By similarity). Phosphorylation of Ser-863 is reduced by induction of long-term depression and increased by induction of long-term potentiation (PubMed:23676497). {ECO:0000250|UniProtKB:P19490, ECO:0000269|PubMed:23676497}.; PTM: Palmitoylated. Depalmitoylated by CPT1C and upon L-glutamate stimulation. ZDHHC3/GODZ specifically palmitoylates Cys-603, which leads to Golgi retention and decreased cell surface expression (PubMed:16129400). In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (PubMed:16129400). {ECO:0000269|PubMed:16129400}.
uniprot
proteins
protein_family
GRIA1 subfamily
uniprot
proteins
protein_family
Glutamate-gated ion channel (TC 1.A.10.1) family
uniprot
proteins
pubmed
12839988
uniprot
proteins
pubmed
16129400
uniprot
proteins
pubmed
16407208
uniprot
proteins
pubmed
16606358
uniprot
proteins
pubmed
1699805
uniprot
proteins
pubmed
18341993
uniprot
proteins
pubmed
20152115
uniprot
proteins
pubmed
21172611
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23524343
uniprot
proteins
pubmed
23676497
uniprot
proteins
pubmed
28334377
uniprot
proteins
pubmed
28642476
uniprot
proteins
pubmed
31651360
uniprot
proteins
pubmed
33981040
uniprot
proteins
sequence_length
907
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21172611}; Multi-pass membrane protein {ECO:0000269|PubMed:21172611}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P19490}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19490}. Postsynaptic cell membrane {ECO:0000269|PubMed:21172611, ECO:0000269|PubMed:28334377, ECO:0000269|PubMed:31651360}; Multi-pass membrane protein {ECO:0000269|PubMed:21172611}. Postsynaptic density membrane {ECO:0000269|PubMed:21172611}; Multi-pass membrane protein {ECO:0000305}. Cell projection, dendrite {ECO:0000269|PubMed:21172611}. Cell projection, dendritic spine {ECO:0000269|PubMed:21172611}. Early endosome membrane {ECO:0000250|UniProtKB:P19490}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19490}. Recycling endosome membrane {ECO:0000250|UniProtKB:P19490}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P19490}. Presynapse {ECO:0000269|PubMed:31651360}. Synapse {ECO:0000269|PubMed:28642476}. Note=Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression. Colocalizes with PDLIM4 in early endosomes. Displays a somatodendritic localization and is excluded from axons in neurons (PubMed:18341993). Localized to cone photoreceptor pedicles (PubMed:28334377). {ECO:0000250|UniProtKB:P19490, ECO:0000269|PubMed:18341993, ECO:0000269|PubMed:28334377}.
uniprot
proteins
transmembrane_region
TRANSMEM 537..557; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 610..630; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 806..826; /note="Helical; Name=M4"; /evidence="ECO:0000250
uniprot
proteins