Q63772
uniprot
Q63772
canonical
amino_acid_sequence
MPPPPGPTAALGTALLLLLLASESSHTVLLRAREAAQFLRPRQRRAYQVFEEAKQGHLERECVEEVCSKEEAREVFENDPETDYFYPRYQECMRKYGRPEDKNPNFATCVKNLPDQCTPNPCDKKGTQLCQDLMGNFFCLCKDGWGGRLCDKDVNECSQKNGGCSQVCHNKPGSFQCACHSGFSLQSDNKSCQDIDECTDSDTCGDARCKNLPGSYSCLCDKGYTYSSKEKTCQDVDECQQDRCEQTCVNSPGSYTCHCNGRGGLKLSPDMDTCEDILPCVPFSMAKSVKSLYLGRMFSGTPVIRLRFKRLQPTRLLAEFDFRTFDPEGVLFFAGGRSDSTWIVLGLRAGRLELQLRYNGVGRITSSGPTINHGMWQTISVEELDRNLVIKVNKDAVMKIAVAGGLFQLERGLYHLNLTVGGIPFKESDLVQPINPRLDGCMRSWNWLNGEDSAIQETVKANTKMQCFSVTERGSFFPGNGFAFYSLNYTRTSLDVGTETTWEVEVVARIRPATDTGVLMALVGDKDVVLLSVALVDYHSTKKLKKQLVVLAVENVALALMEIKVCDSQEHTVTVSLRDGEATLEVDGTKGQSEVSTAQLQERLDLLKTRLQGSVLTFVGGLPDVQVTSTPVTAFYRGCMTLEVNGKTLDLDTASYKHSDITSHSCPPVEHVTA
uniprot
proteins
function
FUNCTION: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
74638
uniprot
proteins
post_translational_modification
PTM: Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium (Probable). {ECO:0000305|PubMed:9163328}.
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
7559388
uniprot
proteins
pubmed
7890695
uniprot
proteins
pubmed
8939948
uniprot
proteins
pubmed
9163328
uniprot
proteins
sequence_length
674
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7559388}.
uniprot
proteins