Apoc1
entrez
25292
canonical
uniprot
P19939
canonical
genesymbol
Apoc1
resolver
uniprot
Q53ZD8
resolver
uniprot_entry
APOC1_RAT
resolver
uniprot_sec
Q53ZD8
resolver
amino_acid_sequence
MRLFIALPVLIVVVAMALEGPAPAQAAPDFSSAMESLPDKLKEFGNTLEDKARAAIEHIKQKEIMIKTRNWFSETLNKMKEKLKTTFA
uniprot
proteins
function
FUNCTION: Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein. {ECO:0000250|UniProtKB:P02654, ECO:0000250|UniProtKB:P33047}.
uniprot
proteins
mass_dalton
9861
uniprot
proteins
protein_family
Apolipoprotein C1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2771655
uniprot
proteins
sequence_length
88
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P02654}.
uniprot
proteins