Icam1
entrez
25464
canonical
uniprot
Q00238
canonical
ensembl
ENSRNOG00000020679
resolver
ensembl
ENSRNOG00055012304
resolver
ensembl
ENSRNOG00060025722
resolver
ensembl
ENSRNOG00065011961
resolver
ensp
ENSRNOP00000028066
resolver
ensp
ENSRNOP00055016925
resolver
ensp
ENSRNOP00060036996
resolver
ensp
ENSRNOP00065014883
resolver
enst
ENSRNOT00000028066
resolver
enst
ENSRNOT00055020953
resolver
enst
ENSRNOT00060044644
resolver
enst
ENSRNOT00065019442
resolver
genesymbol
Icam1
resolver
uniprot_entry
ICAM1_RAT
resolver
amino_acid_sequence
MASTRARPMLPLLLVLVAVVIPGPVGAQVSIHPTEAFLPRGGSVQVNCSSSCEDENLGLGLETNWMKDELSSGHNWKLFKLSDIGEDSRPLCFENCGTTQSSASATITVYSFPERVELDPLPAWQQVGKNLILRCLVEGGAPRTQLSVVLLRGNETLSRQAVDGDPKEITFTVLASRGDHGANFSCFTELDLRPQGLSLFKNVSEVRQLRTFDLPTRVLKLDTPDLLEVGTQQKFLCSLEGLFPASEAQIYLEMGGQMLTLESTNSRDFVSATASVEVTEKLDRTLQLRCVLELADQTLEMEKTLRIYNFSAPILTLSQPEVSEGDQVTVKCEAHGGAQVVLLNSTSPRPPTSQGTSPRPPTSQIQFTLNASPEDHKRRFFCSAALEVDGKSLFKNQTLELHVLYGPHLDKKDCLGNWTWQEGSQQTLTCQPQGNPAPNLTCSRKADGVPLPIGMVKSVKREMNGTYKCRAFSSRGSITRDVHLTVLYHDQNTWVIIVGVLVLIIAGFVIVASIYTYYRQRKIRIYKLQKAQEEALKLKVQAPPP
uniprot
proteins
function
FUNCTION: Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring leukocyte cell-cell adhesion, by providing a calibrated system to namely adjust T-cell killing to the antigen stimulation strength. Also functions as a ligand receptor of the signaling receptor ITGAM:ITGB2/MAC-1 ensuring adhesion between stimulated neutrophils and stimulated endothelial cells. During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation. Promotes cell aggregation in epithelial cells through interaction with MUC1. {ECO:0000250|UniProtKB:P05362}.
uniprot
proteins
mass_dalton
60142
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis. {ECO:0000250|UniProtKB:P05362}.
uniprot
proteins
protein_family
ICAM family
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
1349828
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
545
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P05362}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 493..517; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins