Camk4
entrez
25050
canonical
uniprot
P13234
canonical
ensembl
ENSRNOG00000020478
resolver
ensembl
ENSRNOG00055023745
resolver
ensembl
ENSRNOG00060028383
resolver
ensembl
ENSRNOG00065012456
resolver
ensp
ENSRNOP00000027771
resolver
ensp
ENSRNOP00000072926
resolver
enst
ENSRNOT00000078822
resolver
genesymbol
Camk4
resolver
uniprot
A0A8L2UQP4
resolver
uniprot
A1A5L5
resolver
uniprot
Q63892
resolver
uniprot_entry
A0A8L2UQP4_RAT
resolver
uniprot_entry
KCC4_RAT
resolver
uniprot_sec
A1A5L5
resolver
uniprot_sec
Q63892
resolver
activity_regulation
ACTIVITY REGULATION: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows phosphorylation of Thr-196 within the activation loop by CaMKK1 or CaMKK2. Phosphorylation of Thr-196 results in a 10-20-fold increase in total activity to generate Ca(2+)/calmodulin-independent activity. Autophosphorylation of the N-terminus Ser-11 and Ser-12 is required for full activation. Inactivated by protein phosphatase 2A (PPP2CA/PPP2CB) which dephosphorylates Thr-196, thereby terminating autonomous activity and helping to maintain the enzyme in its autoinhibited state (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MLKVTVPSCPSSPCSSVTSSTENLVPDYWIDGSKRDPLSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVKKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHTNIQESNKASSEAQPAQDGKDKTDPLENKMQAGDHEAAKAAADETMKLQSEEVEEEEGVKEEEEEEEEEEETSRMVPQEPEDRLETDDQEMKRNSEETLKSVEEEMDPKAEEEAAAVGLGVPPQQDAILPEY
uniprot
proteins
ec_number
2.7.11.17
uniprot
proteins
function
FUNCTION: [Isoform 1]: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK4 signaling cascade and regulates, mainly by phosphorylation, the activity of several transcription activators, such as CREB1, MEF2D, JUN and RORA, which play pivotal roles in immune response, inflammation, and memory consolidation. In the thymus, regulates the CD4(+)/CD8(+) double positive thymocytes selection threshold during T-cell ontogeny. In CD4 memory T-cells, is required to link T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG and IL4 (through the regulation of CREB and MEF2). Regulates the differentiation and survival phases of osteoclasts and dendritic cells (DCs). Mediates DCs survival by linking TLR4 and the regulation of temporal expression of BCL2. Phosphorylates the transcription activator CREB1 on 'Ser-133' in hippocampal neuron nuclei and contribute to memory consolidation and long term potentiation (LTP) in the hippocampus. Can activate the MAP kinases MAPK1/ERK2, MAPK8/JNK1 and MAPK14/p38 and stimulate transcription through the phosphorylation of ELK1 and ATF2. Can also phosphorylate in vitro CREBBP, PRM2, MEF2A and STMN1/OP18 (By similarity). {ECO:0000250}.; FUNCTION: [Isoform 2]: Heat-stable, acidic, calmodulin-binding protein. {ECO:0000269|PubMed:1646483, ECO:0000269|PubMed:8065343, ECO:0000269|PubMed:8621702}.
uniprot
proteins
mass_dalton
53151
uniprot
proteins
mutagenesis
MUTAGEN 71; /note="K->M: Loss of kinase activity; confers cytoplasmic localization."; /evidence="ECO:0000269|PubMed:14701808"; MUTAGEN 196; /note="T->A: Loss of kinase activity; confers nuclear localization."; /evidence="ECO:0000269|PubMed:14701808, ECO:0000269|PubMed:7615569"; MUTAGEN 207; /note="E->K: Loss of kinase activity; confers nuclear localization."; /evidence="ECO:0000269|PubMed:14701808"; MUTAGEN 305..308; /note="HMDT->DEDD: Increases Ca(2+)/calmodulin-independent activity."; /evidence="ECO:0000269|PubMed:7961813"; MUTAGEN 316..317; /note="FN->DD: Increases Ca(2+)/calmodulin-independent activity."; /evidence="ECO:0000269|PubMed:7961813"; MUTAGEN 332; /note="S->A: No decrease in Ca(2+)/calmodulin-dependent activity after activation by CaMKKs."; /evidence="ECO:0000269|PubMed:8636117
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CaMKK1 and CaMKK2 on Thr-196. Dephosphorylated by protein phosphatase 2A. Autophosphorylated on Ser-11 and Ser-12 (By similarity). {ECO:0000250}.; PTM: Glycosylation at Ser-185 modulates the phosphorylation of CaMK4 at Thr-196 and negatively regulates its activity toward CREB1 in basal conditions and during early inomycin stimulation. {ECO:0000250}.; PTM: The N-terminus of calspermin is blocked.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
CaMK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10336483
uniprot
proteins
pubmed
14701808
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1646483
uniprot
proteins
pubmed
1648230
uniprot
proteins
pubmed
1649385
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2538431
uniprot
proteins
pubmed
2914893
uniprot
proteins
pubmed
7493991
uniprot
proteins
pubmed
7592527
uniprot
proteins
pubmed
7615569
uniprot
proteins
pubmed
7961813
uniprot
proteins
pubmed
8065343
uniprot
proteins
pubmed
8412563
uniprot
proteins
pubmed
8621702
uniprot
proteins
pubmed
8631893
uniprot
proteins
pubmed
8636117
uniprot
proteins
pubmed
9596578
uniprot
proteins
pubmed
9822657
uniprot
proteins
sequence_length
474
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Localized in hippocampal neuron nuclei. In spermatids, associated with chromatin and nuclear matrix. {ECO:0000250}.
uniprot
proteins