Btg2
entrez
12227
canonical
uniprot
Q04211
canonical
ensembl
ENSMUSG00000020423
resolver
ensp
ENSMUSP00000020692
resolver
enst
ENSMUST00000020692
resolver
genesymbol
Btg2
resolver
genesymbol_syn
Tis21
resolver
uniprot
Q3TF68
resolver
uniprot_entry
BTG2_MOUSE
resolver
uniprot_entry
Q3TF68_MOUSE
resolver
amino_acid_sequence
MSHGKRTDMLPEIAAAVGFLSSLLRTRGCVSEQRLKVFSRALQDALTDHYKHHWFPEKPSKGSGYRCIRINHKMDPIISKVASQIGLSQPQLHRLLPSELTLWVDPYEVSYRIGEDGSICVLYEEAPVAASYGLLTCKNQMMLGRSSPSKNYVMAVSS
uniprot
proteins
function
FUNCTION: Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex. Activates mRNA deadenylation in a CNOT6 and CNOT7-dependent manner. In vitro can inhibit deadenylase activity of CNOT7 and CNOT8. Involved in cell cycle regulation. Could be involved in the growth arrest and differentiation of the neuronal precursors. Modulates transcription regulation mediated by ESR1. Involved in mitochondrial depolarization and neurite outgrowth (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
17682
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-147 by MAPK1/ERK2 and MAPK3/ERK1, and at Ser-149 by MAPK14, leading to PIN1-binding and mitochondrial depolarization. {ECO:0000250}.
uniprot
proteins
protein_family
BTG family
uniprot
proteins
pubmed
1713584
uniprot
proteins
sequence_length
158
uniprot
proteins