Cox6c
entrez
12864
canonical
uniprot
Q9CPQ1
canonical
ensembl
ENSMUSG00000014313
resolver
ensp
ENSMUSP00000014457
resolver
ensp
ENSMUSP00000122391
resolver
ensp
ENSMUSP00000123609
resolver
enst
ENSMUST00000014457
resolver
enst
ENSMUST00000153512
resolver
enst
ENSMUST00000156915
resolver
genesymbol
Cox6c
resolver
uniprot
Q52KC6
resolver
uniprot_entry
COX6C_MOUSE
resolver
uniprot_sec
Q52KC6
resolver
amino_acid_sequence
MSSGALLPKPQMRGLLAKRLRVHIAGAFIVALGVAAAYKFGVAEPRKKAYAEFYRNYDSMKDFEEMRKAGIFQSAK
uniprot
proteins
function
FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000269|PubMed:34616041, ECO:0000269|PubMed:38575788}.
uniprot
proteins
mass_dalton
8469
uniprot
proteins
pathway_participation
PATHWAY: Energy metabolism; oxidative phosphorylation. {ECO:0000269|PubMed:34616041, ECO:0000269|PubMed:38575788}.
uniprot
proteins
post_translational_modification
PTM: Acetylation of Lys-61 is observed in liver mitochondria from fasted mice but not from fed mice.
uniprot
proteins
protein_family
Cytochrome c oxidase subunit 6c family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1645653
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
34616041
uniprot
proteins
pubmed
38575788
uniprot
proteins
sequence_length
76
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:34616041, ECO:0000269|PubMed:38575788}; Single-pass membrane protein {ECO:0000269|PubMed:34616041}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..44; /note="Helical"; /evidence="ECO:0000269|PubMed:34616041, ECO:0007744|PDB:7O37, ECO:0007744|PDB:7O3C
uniprot
proteins