RIN2
entrez
54453
canonical
uniprot
Q8WYP3
canonical
ensembl
ENSG00000132669
resolver
ensp
ENSP00000255006
resolver
ensp
ENSP00000614257
resolver
ensp
ENSP00000614259
resolver
ensp
ENSP00000614262
resolver
genesymbol
RIN2
resolver
genesymbol_syn
RASSF4
resolver
hgnc
HGNC:18750
resolver
uniprot
A1A4T0
resolver
uniprot
Q00425
resolver
uniprot
Q5TFT8
resolver
uniprot
Q9BQL3
resolver
uniprot
Q9H071
resolver
uniprot_entry
A1A4T0_HUMAN
resolver
uniprot_entry
RIN2_HUMAN
resolver
uniprot_sec
Q00425
resolver
uniprot_sec
Q5TFT8
resolver
uniprot_sec
Q9BQL3
resolver
uniprot_sec
Q9H071
resolver
amino_acid_sequence
MTAWTMGARGLDKRGSFFKLIDTIASEIGELKQEMVRTDVNLENGLEPAETHSMVRHKDGGYSEEEDVKTCARDSGYDSLSNRLSILDRLLHTHPIWLQLSLSEEEAAEVLQAQPPGIFLVHKSTKMQKKVLSLRLPCEFGAPLKEFAIKESTYTFSLEGSGISFADLFRLIAFYCISRDVLPFTLKLPYAISTAKSEAQLEELAQMGLNFWSSPADSKPPNLPPPHRPLSSDGVCPASLRQLCLINGVHSIKTRTPSELECSQTNGALCFINPLFLKVHSQDLSGGLKRPSTRTPNANGTERTRSPPPRPPPPAINSLHTSPRLARTETQTSMPETVNHNKHGNVALPGTKPTPIPPPRLKKQASFLEAEGGAKTLSGGRPGAGPELELGTAGSPGGAPPEAAPGDCTRAPPPSSESRPPCHGGRQRLSDMSISTSSSDSLEFDRSMPLFGYEADTNSSLEDYEGESDQETMAPPIKSKKKRSSSFVLPKLVKSQLQKVSGVFSSFMTPEKRMVRRIAELSRDKCTYFGCLVQDYVSFLQENKECHVSSTDMLQTIRQFMTQVKNYLSQSSELDPPIESLIPEDQIDVVLEKAMHKCILKPLKGHVEAMLKDFHMADGSWKQLKENLQLVRQRNPQELGVFAPTPDFVDVEKIKVKFMTMQKMYSPEKKVMLLLRVCKLIYTVMENNSGRMYGADDFLPVLTYVIAQCDMLELDTEIEYMMELLDPSLLHGEGGYYLTSAYGALSLIKNFQEEQAARLLSSETRDTLRQWHKRRTTNRTIPSVDDFQNYLRVAFQEVNSGCTGKTLLVRPYITTEDVCQICAEKFKVGDPEEYSLFLFVDETWQQLAEDTYPQKIKAELHSRPQPHIFHFVYKRIKNDPYGIIFQNGEEDLTTS
uniprot
proteins
disease_involvement
DISEASE: MACS syndrome (MACS) [MIM:613075]: A complex disorder of elastic tissue characterized by sagging skin and occasionally by life-threatening visceral complications. {ECO:0000269|PubMed:19631308}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Ras effector protein. May function as an upstream activator and/or downstream effector for RAB5B in endocytic pathway. May function as a guanine nucleotide exchange (GEF) of RAB5B, required for activating the RAB5 proteins by exchanging bound GDP for free GTP. {ECO:0000269|PubMed:11733506}.
uniprot
proteins
mass_dalton
100163
uniprot
proteins
protein_family
RIN (Ras interaction/interference) family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
11733506
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
1849280
uniprot
proteins
pubmed
19631308
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
895
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
uniprot
proteins