IRX3
entrez
79191
canonical
uniprot
P78415
canonical
ensembl
ENSG00000177508
resolver
ensp
ENSP00000331608
resolver
ensp
ENSP00000703186
resolver
enst
ENST00000329734
resolver
genesymbol
IRX3
resolver
genesymbol_syn
IRXB1
resolver
hgnc
HGNC:14360
resolver
uniprot
Q7Z4A4
resolver
uniprot
Q7Z4A5
resolver
uniprot
Q8IVC6
resolver
uniprot_entry
IRX3_HUMAN
resolver
uniprot_sec
Q7Z4A4
resolver
uniprot_sec
Q7Z4A5
resolver
uniprot_sec
Q8IVC6
resolver
amino_acid_sequence
MSFPQLGYQYIRPLYPSERPGAAGGSGGSAGARGGLGAGASELNASGSLSNVLSSVYGAPYAAAAAAAAAQGYGAFLPYAAELPIFPQLGAQYELKDSPGVQHPAAAAAFPHPHPAFYPYGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEDGKRELELEEEELGGEEEDTGGEGLADDDEDEEIDLENLDGAATEPELSLAGAARRDGDLGLGPISDSKNSDSEDSSEGLEDRPLPVLSLAPAPPPVAVASPSLPSPPVSLDPCAPAPAPASALQKPKIWSLAETATSPDNPRRSPPGAGGSPPGAAVAPSALQLSPAAAAAAAHRLVSAPLGKFPAWTNRPFPGPPPGPRLHPLSLLGSAPPHLLGLPGAAGHPAAAAAFARPAEPEGGTDRCSALEVEKKLLKTAFQPVPRRPQNHLDAALVLSALSSS
uniprot
proteins
function
FUNCTION: Transcription factor involved in SHH-dependent neural patterning. Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals. Involved in the transcriptional repression of MNX1 in non-motor neuron cells. Acts as a regulator of energy metabolism. {ECO:0000250|UniProtKB:P81067}.
uniprot
proteins
mass_dalton
52119
uniprot
proteins
protein_family
TALE/IRO homeobox family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
501
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins