Mas1
entrez
25153
canonical
uniprot
P12526
canonical
ensembl
ENSRNOG00000014971
resolver
ensembl
ENSRNOG00055027635
resolver
ensembl
ENSRNOG00060009693
resolver
ensembl
ENSRNOG00065029142
resolver
ensp
ENSRNOP00000020100
resolver
ensp
ENSRNOP00000097396
resolver
ensp
ENSRNOP00000100269
resolver
ensp
ENSRNOP00000100641
resolver
ensp
ENSRNOP00000103225
resolver
ensp
ENSRNOP00000104659
resolver
ensp
ENSRNOP00000104990
resolver
ensp
ENSRNOP00000107483
resolver
ensp
ENSRNOP00000111055
resolver
ensp
ENSRNOP00000111850
resolver
ensp
ENSRNOP00055039401
resolver
ensp
ENSRNOP00055039409
resolver
ensp
ENSRNOP00060012764
resolver
ensp
ENSRNOP00060012771
resolver
ensp
ENSRNOP00065041362
resolver
ensp
ENSRNOP00065041383
resolver
enst
ENSRNOT00000020100
resolver
enst
ENSRNOT00000104217
resolver
enst
ENSRNOT00000127520
resolver
enst
ENSRNOT00000128446
resolver
enst
ENSRNOT00000132244
resolver
enst
ENSRNOT00000134627
resolver
enst
ENSRNOT00000139763
resolver
enst
ENSRNOT00000163978
resolver
enst
ENSRNOT00000164553
resolver
enst
ENSRNOT00000169457
resolver
enst
ENSRNOT00055047860
resolver
enst
ENSRNOT00055047868
resolver
enst
ENSRNOT00060016345
resolver
enst
ENSRNOT00060016354
resolver
enst
ENSRNOT00065050341
resolver
enst
ENSRNOT00065050362
resolver
genesymbol
Mas1
resolver
genesymbol_syn
Mas
resolver
genesymbol_syn
Mas-1
resolver
uniprot_entry
MAS_RAT
resolver
amino_acid_sequence
MDQSNMTSFAEEKAMNTSSRNASLGTSHPPIPIVHWVIMSISPLGFVENGILLWFLCFRMRRNPFTVYITHLSIADISLLFCIFILSIDYALDYELSSGHYYTIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIWYRCHRPKHQSAFVCALLWALSCLVTTMEYVMCIDSGEESHSQSDCRAVIIFIAILSFLVFTPLMLVSSTILVVKIRKNTWASHSSKLYIVIMVTIIIFLIFAMPMRVLYLLYYEYWSTFGNLHNISLLFSTINSSANPFIYFFVGSSKKKRFRESLKVVLTRAFKDEMQPRRQEGNGNTVSIETVV
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that plays key roles in the renin-angiotensin system (RAS) specifically in the protective, counter-regulatory arm of the RAS. Receptor mainly stimulated by angiotensin 1-7, which is a bioactive metabolite of the angiotensin produced by ACE2. Activation promotes nitric oxide via PI3K/Akt-eNOS pathway. Modulates also the MAPK, ERK1/2, and NF-kappa-B signaling. Positive regulation of AGTR1 levels occurs through activation of the G proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. Acts as functional receptor for CXCL17 and induces chemotactic movement. {ECO:0000250|UniProtKB:P04201, ECO:0000250|UniProtKB:P30554}.
uniprot
proteins
mass_dalton
37131
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18026570
uniprot
proteins
pubmed
2455902
uniprot
proteins
sequence_length
324
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P04201}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..60; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 65..86; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 104..127; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 149..171; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 185..205; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 224..244; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 263..283; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins