Cplx3
entrez
235415
canonical
uniprot
Q8R1B5
canonical
ensembl
ENSMUSG00000039714
resolver
ensp
ENSMUSP00000046748
resolver
enst
ENSMUST00000045068
resolver
genesymbol
Cplx3
resolver
uniprot
Q96AW7
resolver
uniprot_entry
CPLX3_MOUSE
resolver
uniprot_sec
Q96AW7
resolver
amino_acid_sequence
MAFMVKSMVGGQLKNLTGSLGGGEDKGDGDKSAAEAQGMSREEYEEYQKQLVEEKMERDAQFTQRKAERATLRSHFRDKYRLPKNETDESQIQLAGGDVELPRELAKMIEEDTEEEEDKASVLGQLASLPGLDLSSLKDKAQTTLGDLKQSAEKCHIM
uniprot
proteins
function
FUNCTION: Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (PubMed:19386896). Required for the maintenance of synaptic ultrastructure in the adult retina (PubMed:19386896). Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (PubMed:15911881, PubMed:19386896, PubMed:27335398). Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release (PubMed:22694764, PubMed:27335398). {ECO:0000269|PubMed:15911881, ECO:0000269|PubMed:19386896, ECO:0000269|PubMed:22694764, ECO:0000269|PubMed:27335398}.
uniprot
proteins
mass_dalton
17586
uniprot
proteins
post_translational_modification
PTM: Farnesylation mediates presynaptic targeting. {ECO:0000269|PubMed:15911881}.
uniprot
proteins
protein_family
Complexin/synaphin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15911881
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19386896
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22694764
uniprot
proteins
pubmed
27335398
uniprot
proteins
sequence_length
158
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Synapse {ECO:0000269|PubMed:15911881, ECO:0000269|PubMed:22694764}. Cell membrane {ECO:0000269|PubMed:15911881}; Lipid-anchor {ECO:0000269|PubMed:15911881}. Note=Enriched at the synaptic terminal (PubMed:15911881). Localized at glycinergic synaptic contacts of AII amacrine cells with OFF cone bipolar cells in the OFF sublamina of the retina inner nuclear layer (PubMed:22694764). {ECO:0000269|PubMed:15911881, ECO:0000269|PubMed:22694764}.
uniprot
proteins