TDRKH
entrez
11022
canonical
uniprot
Q9Y2W6
canonical
ensembl
ENSG00000182134
resolver
ensp
ENSP00000357812
resolver
ensp
ENSP00000357815
resolver
ensp
ENSP00000357817
resolver
ensp
ENSP00000357819
resolver
ensp
ENSP00000395718
resolver
ensp
ENSP00000563186
resolver
ensp
ENSP00000563192
resolver
ensp
ENSP00000563194
resolver
genesymbol
TDRKH
resolver
genesymbol_syn
TDRD2
resolver
hgnc
HGNC:11713
resolver
uniprot
B4DJ68
resolver
uniprot
D3DV24
resolver
uniprot
Q5SZR3
resolver
uniprot
Q5SZR5
resolver
uniprot
Q8N582
resolver
uniprot
Q9NYV5
resolver
uniprot_entry
B4DJ68_HUMAN
resolver
uniprot_entry
TDRKH_HUMAN
resolver
uniprot_sec
D3DV24
resolver
uniprot_sec
Q5SZR3
resolver
uniprot_sec
Q5SZR5
resolver
uniprot_sec
Q8N582
resolver
uniprot_sec
Q9NYV5
resolver
amino_acid_sequence
MSTERTSWTSLSTIQKIALGLGIPASATVAYILYRRYRESREERLTFVGEDDIEIEMRVPQEAVKLIIGRQGANIKQLRKQTGARIDVDTEDVGDERVLLISGFPVQVCKAKAAIHQILTENTPVSEQLSVPQRSVGRIIGRGGETIRSICKASGAKITCDKESEGTLLLSRLIKISGTQKEVAAAKHLILEKVSEDEELRKRIAHSAETRVPRKQPISVRREDMTEPGGAGEPALWKNTSSSMEPTAPLVTPPPKGGGDMAVVVSKEGSWEKPSDDSFQKSEAQAIPEMPMFEIPSPDFSFHADEYLEVYVSASEHPNHFWIQIVGSRSLQLDKLVNEMTQHYENSVPEDLTVHVGDIVAAPLPTNGSWYRARVLGTLENGNLDLYFVDFGDNGDCPLKDLRALRSDFLSLPFQAIECSLARIAPSGDQWEEEALDEFDRLTHCADWKPLVAKISSYVQTGISTWPKIYLYDTSNGKKLDIGLELVHKGYAIELPEDIEENRAVPDMLKDMATETDASLSTLLTETKKSSGEITHTLSCLSLSEAASMSGDDNLEDDYLL
uniprot
proteins
function
FUNCTION: Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules. {ECO:0000250|UniProtKB:Q80VL1}.
uniprot
proteins
mass_dalton
62046
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. {ECO:0000269|PubMed:25621951}.
uniprot
proteins
protein_family
Tdrkh family
uniprot
proteins
pubmed
10767542
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25621951
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
561
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q80VL1}. Mitochondrion {ECO:0000250|UniProtKB:Q80VL1}. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. Colocalizes with pi- and piP-bodies, a subset of the nuage which contains secondary piRNAs. Associated with mitochondria in the germline. {ECO:0000250|UniProtKB:Q80VL1}.
uniprot
proteins