Hk1
entrez
15275
canonical
uniprot
P17710
canonical
ensembl
ENSMUSG00000037012
resolver
ensp
ENSMUSP00000097282
resolver
ensp
ENSMUSP00000111946
resolver
ensp
ENSMUSP00000114586
resolver
ensp
ENSMUSP00000115218
resolver
ensp
ENSMUSP00000115426
resolver
ensp
ENSMUSP00000115990
resolver
ensp
ENSMUSP00000118576
resolver
ensp
ENSMUSP00000118601
resolver
ensp
ENSMUSP00000121487
resolver
ensp
ENSMUSP00000122479
resolver
ensp
ENSMUSP00000122717
resolver
ensp
ENSMUSP00000122791
resolver
ensp
ENSMUSP00000123375
resolver
enst
ENSMUST00000130091
resolver
enst
ENSMUST00000130422
resolver
enst
ENSMUST00000132926
resolver
enst
ENSMUST00000133429
resolver
enst
ENSMUST00000134447
resolver
enst
ENSMUST00000134877
resolver
enst
ENSMUST00000135317
resolver
enst
ENSMUST00000136548
resolver
enst
ENSMUST00000140383
resolver
enst
ENSMUST00000143236
resolver
enst
ENSMUST00000154489
resolver
genesymbol
Hk1
resolver
uniprot
B4YB29
resolver
uniprot
E9PXQ3
resolver
uniprot
F6U8I5
resolver
uniprot
G3UVV4
resolver
uniprot
Q3TTB4
resolver
uniprot
Q61659
resolver
uniprot
Q64476
resolver
uniprot
Q64479
resolver
uniprot
Q6GQU1
resolver
uniprot_entry
B4YB29_MOUSE
resolver
uniprot_entry
F6U8I5_MOUSE
resolver
uniprot_entry
G3UVV4_MOUSE
resolver
uniprot_entry
HXK1_MOUSE
resolver
uniprot_entry
Q3TTB4_MOUSE
resolver
uniprot_entry
Q6GQU1_MOUSE
resolver
uniprot_sec
E9PXQ3
resolver
uniprot_sec
Q61659
resolver
uniprot_sec
Q64476
resolver
uniprot_sec
Q64479
resolver
activity_regulation
ACTIVITY REGULATION: Hexokinase is an allosteric enzyme inhibited by its product D-glucose 6-phosphate. Hexokinase activity is inhibited by N-acetyl-D-glucosamine. {ECO:0000250|UniProtKB:P19367}.
uniprot
proteins
amino_acid_sequence
MGWGAPLLSRMLHGPGQAGETSPVPERQSGSENPASEDRRPLEKQCSHHLYTMGQNCQRGQAVDVEPKIRPPLTEEKIDKYLYAMRLSDEILIDILTRFKKEMKNGLSRDYNPTASVKMLPTFVRSIPDGSEKGDFIALDLGGSSFRILRVQVNHEKSQNVSMESEVYDTPENIVHGSGSQLFDHVAECLGDFMEKRKIKDKKLPVGFTFSFPCRQSKIDEAVLITWTKRFKASGVEGADVVKLLNKAIKKRGDYDANIVAVVNDTVGTMMTCGYDDQQCEVGLIIGTGTNACYMEELRHIDLVEGDEGRMCINTEWGAFGDDGSLEDIRTEFDRELDRGSLNPGKQLFEKMVSGMYMGELVRLILVKMAKESLLFEGRITPELLTRGKFTTSDVAAIETDKEGVQNAKEILTRLGVEPSHDDCVSVQHVCTIVSFRSANLVAATLGAILNRLRDNKGTPRLRTTVGVDGSLYKMHPQYSRRFHKTLRRLVPDSDVRFLLSESGSGKGAAMVTAVAYRLAEQHRQIEETLSHFRLSKQALMEVKKKLRSEMEMGLRKETNSRATVKMLPSYVRSIPDGTEHGDFLALDLGGTNFRVLLVKIRSGKKRTVEMHNKIYSIPLEIMQGTGDELFDHIVSCISDFLDYMGIKGPRMPLGFTFSFPCKQTSLDCGILITWTKGFKATDCVGHDVATLLRDAVKRREEFDLDVVAVVNDTVGTMMTCAYEEPSCEIGLIVGTGSNACYMEEMKNVEMVEGNQGQMCINMEWGAFGDNGCLDDIRTDFDKVVDEYSLNSGKQRFEKMISGMYLGEIVRNILIDFTKKGFLFRGQISEPLKTRGIFETKFLSQIESDRLALLQVRAILQQLGLNSTCDDSILVKTVCGVVSKRAAQLCGAGMAAVVEKIRENRGLDHLNVTVGVDGTLYKLHPHFSRIMHQTVKELSPKCTVSFLLSEDGSGKGAALITAVGVRLRGDPTNA
uniprot
proteins
ec_number
2.7.1.1
uniprot
proteins
function
FUNCTION: Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan. When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (PubMed:27374331). {ECO:0000250|UniProtKB:P05708, ECO:0000250|UniProtKB:P19367, ECO:0000269|PubMed:27374331}.
uniprot
proteins
mass_dalton
108303
uniprot
proteins
mutagenesis
MUTAGEN 67; /note="P->A: Disrupts targeting to membrane; when associated with N-68; Q-70; P-73; A-74 and Q-75."; /evidence="ECO:0000269|PubMed:10567428"; MUTAGEN 68; /note="K->N: Disrupts targeting to membrane; when associated with A-67; Q-70; P-73; A-74 and Q-75."; /evidence="ECO:0000269|PubMed:10567428"; MUTAGEN 70; /note="R->Q: Disrupts targeting to membrane; when associated with A-67; N-68; P-73; A-74 and Q-75."; /evidence="ECO:0000269|PubMed:10567428"; MUTAGEN 73; /note="L->P: Disrupts targeting to membrane; when associated with A-67; N-68; Q-70; A-74 and Q-75."; /evidence="ECO:0000269|PubMed:10567428"; MUTAGEN 74; /note="T->A: Disrupts targeting to membrane; when associated with A-67; N-68; Q-70; P-73 and Q-75."; /evidence="ECO:0000269|PubMed:10567428"; MUTAGEN 75; /note="E->Q: Disrupts targeting to membrane; when associated with A-67; N-68; Q-70; P-73 and A-74."; /evidence="ECO:0000269|PubMed:10567428
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate metabolism; hexose metabolism. {ECO:0000250|UniProtKB:P19367}.; PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4. {ECO:0000250|UniProtKB:P05708}.
uniprot
proteins
post_translational_modification
PTM: [Isoform HK1-SC]: Tyrosine-phosphorylated. {ECO:0000269|PubMed:9450953}.
uniprot
proteins
protein_family
Hexokinase family
uniprot
proteins
pubmed
10567428
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19889946
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23055941
uniprot
proteins
pubmed
2318862
uniprot
proteins
pubmed
27374331
uniprot
proteins
pubmed
8396993
uniprot
proteins
pubmed
9450953
uniprot
proteins
sequence_length
974
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:27374331}; Peripheral membrane protein {ECO:0000250|UniProtKB:P19367}. Cytoplasm, cytosol {ECO:0000269|PubMed:27374331}. Note=The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane (By similarity). Dissociates from the mitochondrial outer membrane following inhibition by N-acetyl-D-glucosamine, leading to relocation to the cytosol (PubMed:27374331). {ECO:0000250|UniProtKB:P19367, ECO:0000269|PubMed:27374331}.; SUBCELLULAR LOCATION: [Isoform HK1]: Mitochondrion outer membrane {ECO:0000269|PubMed:9450953}; Peripheral membrane protein {ECO:0000269|PubMed:9450953}.; SUBCELLULAR LOCATION: [Isoform HK1-SC]: Membrane {ECO:0000269|PubMed:9450953}. Note=Isoform HK1-SC is an integral membrane protein. {ECO:0000269|PubMed:9450953}.
uniprot
proteins