CAMK1
entrez
8536
canonical
uniprot
Q14012
canonical
ensembl
ENSG00000134072
resolver
ensp
ENSP00000256460
resolver
ensp
ENSP00000526650
resolver
ensp
ENSP00000526652
resolver
ensp
ENSP00000526653
resolver
ensp
ENSP00000526655
resolver
ensp
ENSP00000653625
resolver
enst
ENST00000256460
resolver
enst
ENST00000856591
resolver
enst
ENST00000856594
resolver
enst
ENST00000856596
resolver
genesymbol
CAMK1
resolver
hgnc
HGNC:1459
resolver
uniprot
A0A024R2D6
resolver
uniprot
B0YIY3
resolver
uniprot
Q3KPF6
resolver
uniprot_entry
B0YIY3_HUMAN
resolver
uniprot_entry
KCC1A_HUMAN
resolver
uniprot_sec
A0A024R2D6
resolver
uniprot_sec
Q3KPF6
resolver
activity_regulation
ACTIVITY REGULATION: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows phosphorylation of Thr-177 within the activation loop by CaMKK1 or CaMKK2. Phosphorylation of Thr-177 results in several fold increase in total activity. Unlike CaMK4, is unable to exhibit autonomous activity after Ca(2+)/calmodulin activation. {ECO:0000269|PubMed:23028635, ECO:0000269|PubMed:7641687}.
uniprot
proteins
amino_acid_sequence
MLGAVEGPRWKQAEDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKEALEGKEGSMENEIAVLHKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIFQVLDAVKYLHDLGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVLAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDPEKRFTCEQALQHPWIAGDTALDKNIHQSVSEQIKKNFAKSKWKQAFNATAVVRHMRKLQLGTSQEGQGQTASHGELLTPVAGGPAAGCCCRDCCVEPGTELSPTLPHQL
uniprot
proteins
ec_number
2.7.11.17
uniprot
proteins
function
FUNCTION: Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, regulates transcription activators activity, cell cycle, hormone production, cell differentiation, actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation, promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors, promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694', which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91', 'Ser-92', 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1, ATF1, CFTR, MYL9 and SYN1/synapsin I. {ECO:0000250, ECO:0000269|PubMed:11114197, ECO:0000269|PubMed:12193581, ECO:0000269|PubMed:14507913, ECO:0000269|PubMed:14754892, ECO:0000269|PubMed:17056143, ECO:0000269|PubMed:17442826, ECO:0000269|PubMed:18184567, ECO:0000269|PubMed:20181577}.
uniprot
proteins
mass_dalton
41337
uniprot
proteins
mutagenesis
MUTAGEN 49; /note="K->A: Catalytically inactive form; prevents CDK4 activation."; /evidence="ECO:0000269|PubMed:14754892, ECO:0000269|PubMed:7641687"; MUTAGEN 177; /note="T->A: Loss of activation by CaMKK1."; /evidence="ECO:0000269|PubMed:7641687"; MUTAGEN 177; /note="T->D: Partial activation in absence of CaMKK1."; /evidence="ECO:0000269|PubMed:7641687
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CaMKK1 and CaMKK2 on Thr-177. {ECO:0000269|PubMed:11395482, ECO:0000269|PubMed:7641687, ECO:0000269|PubMed:9662074}.; PTM: Polybiquitinated by the E3 ubiquitin-protein ligase complex SCF(FBXL12), leading to proteasomal degradation. {ECO:0000269|PubMed:23707388}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
CaMK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11114197
uniprot
proteins
pubmed
11395482
uniprot
proteins
pubmed
11749376
uniprot
proteins
pubmed
12193581
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
14507913
uniprot
proteins
pubmed
14754892
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17056143
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17442826
uniprot
proteins
pubmed
18184567
uniprot
proteins
pubmed
18817731
uniprot
proteins
pubmed
20181577
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21301225
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23028635
uniprot
proteins
pubmed
23707388
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
7641687
uniprot
proteins
pubmed
9662074
uniprot
proteins
sequence_length
370
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. {ECO:0000250}.
uniprot
proteins