Mtmr12
entrez
310155
canonical
uniprot
Q5FVM6
canonical
ensembl
ENSRNOG00000022929
resolver
ensp
ENSRNOP00000036677
resolver
genesymbol
Mtmr12
resolver
genesymbol_syn
Pip3ap
resolver
uniprot_entry
MTMRC_RAT
resolver
amino_acid_sequence
MLGKGGVGGGGGTKAPKPSFVSYVRPEEIHTNEKEVTEKEEVTLHLLPGEQLLCEASTVLKYVQEDSCQLGICGRLVCTDFRISFLGDEGSAVDNGAETHFKNKIIGVNDIPLHCVDQIYGVFDEKKKPLFGQLKKYPEKLVIHCKDLRVLHFCLRYTKEEEVKRIVSGIIHHTQSPKLLKRLFLFSYAAAVHGTAADPRNCTVMFDTPKDWCWELERTKGSVKYKTVSVNEGYRVCDRLPAYFVVPTPLLEDDVKRFQGRGIPIWCWSCHNGSALLKMSALPKEQDDSALQIQKSFLDGIYKTIHRPPYEMVKTEDLSSNFLSLQEIQSSYCKFKQLFLIDSSSEFWDTDVKWFSLLESSGWLDIIRRCLKRAIEIIECLEAQNMNVLLLEENASDLCCLLSSLVQVMMDAHCRTWTGFQSLIQKEWVMGGHSFLDRCNHLHQSDKEEVPVFLLFLDCVWQLVHQHPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDTNMGRESLDAQSKPLTLLTVWDWSVQFEPKAQTLLRNPLYVEKPKLDKGQRKGSRFKHQRQLSLPLTQSKSSPKRGFFREETDHLIKNLLGKRISKLINSSDDLQDNSREFYDNWHSKPTDYHGLLLPHIEGPEIKVWAQRYLRWIPEAQILGGGRVATMGKLLEMMEEVQSLQEKIEARHHRQEAIHVQAPGLLRNSARLSSLFPFAMHQRHSAKPVLPTSGWKALGGEDDLAKREDEFVDLGDV
uniprot
proteins
function
FUNCTION: Acts as an adapter for the myotubularin-related phosphatases. Regulates phosphatase MTM1 protein stability and possibly its intracellular location. By stabilizing MTM1 protein levels, required for skeletal muscle maintenance but not for myogenesis. {ECO:0000250|UniProtKB:Q80TA6}.
uniprot
proteins
mass_dalton
85686
uniprot
proteins
protein_family
Non-receptor class myotubularin subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
748
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9C0I1}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q80TA6}. Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:Q80TA6}. Note=Localizes to punctate vesicles when associated with MTM1 (By similarity). Localizes to triads, a structure formed by a T tubule and two sarcoplasmic reticulum terminal cisterna. In skeletal muscles, co-localizes with MTM1 in the sarcomere. Partially localizes to the sarcoplasmic reticulum in skeletal muscles (By similarity). {ECO:0000250|UniProtKB:Q80TA6, ECO:0000250|UniProtKB:Q9C0I1}.
uniprot
proteins