SOD3
entrez
6649
canonical
uniprot
P08294
canonical
ensembl
ENSG00000109610
resolver
ensp
ENSP00000371554
resolver
ensp
ENSP00000550324
resolver
ensp
ENSP00000622087
resolver
ensp
ENSP00000622088
resolver
ensp
ENSP00000622089
resolver
ensp
ENSP00000622090
resolver
enst
ENST00000382120
resolver
enst
ENST00000880265
resolver
enst
ENST00000952028
resolver
enst
ENST00000952029
resolver
enst
ENST00000952030
resolver
enst
ENST00000952031
resolver
genesymbol
SOD3
resolver
hgnc
HGNC:11181
resolver
uniprot
A0A140VJU8
resolver
uniprot
Q5U781
resolver
uniprot
Q6FHA2
resolver
uniprot_entry
A0A140VJU8_HUMAN
resolver
uniprot_entry
SODE_HUMAN
resolver
uniprot_sec
Q5U781
resolver
uniprot_sec
Q6FHA2
resolver
amino_acid_sequence
MLALLCSCLLLAAGASDAWTGEDSAEPNSDSAEWIRDMYAKVTEIWQEVMQRRDDDGALHAACQVQPSATLDAAQPRVTGVVLFRQLAPRAKLDAFFALEGFPTEPNSSSRAIHVHQFGDLSQGCESTGPHYNPLAVPHPQHPGDFGNFAVRDGSLWRYRAGLAASLAGPHSIVGRAVVVHAGEDDLGRGGNQASVENGNAGRRLACCVVGVCGPGLWERQAREHSERKKRRRESECKAA
uniprot
proteins
ec_number
1.15.1.1
uniprot
proteins
function
FUNCTION: Secreted antioxidant enzyme that acts as the primary scavenger of superoxide radicals in the extracellular space, converting them to hydrogen peroxide and thereby protecting tissues from oxidative damage (PubMed:12933702, PubMed:15761197). Also preserves nitric oxide bioavailability by preventing the formation of harmful peroxynitrite (PubMed:12933702). Stored in intracellular pre-formed vesicles of macrophages and neutrophils and released upon stimulation by inflammatory mediators (PubMed:31326693). {ECO:0000269|PubMed:12933702, ECO:0000269|PubMed:15761197, ECO:0000269|PubMed:31326693}.
uniprot
proteins
mass_dalton
25851
uniprot
proteins
protein_family
Cu-Zn superoxide dismutase family
uniprot
proteins
pubmed
12933702
uniprot
proteins
pubmed
1505778
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15761197
uniprot
proteins
pubmed
16087389
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
16371425
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19289127
uniprot
proteins
pubmed
31326693
uniprot
proteins
pubmed
3476950
uniprot
proteins
pubmed
7662997
uniprot
proteins
pubmed
7959763
uniprot
proteins
pubmed
8034674
uniprot
proteins
pubmed
8546689
uniprot
proteins
pubmed
8864862
uniprot
proteins
sequence_length
240
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000269|PubMed:8546689}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:O09164}. Vesicle {ECO:0000269|PubMed:31326693}. Note=99% of SOD3/EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium (PubMed:8546689). In macrophages and neutrophiles, extracellular SOD2 in endocytosed and stored in intracellular vesicles (PubMed:31326693). {ECO:0000269|PubMed:31326693, ECO:0000269|PubMed:8546689}.
uniprot
proteins