PHF23
entrez
79142
canonical
uniprot
Q9BUL5
canonical
ensembl
ENSG00000040633
resolver
ensp
ENSP00000322579
resolver
ensp
ENSP00000414607
resolver
ensp
ENSP00000458953
resolver
ensp
ENSP00000460738
resolver
enst
ENST00000576955
resolver
genesymbol
PHF23
resolver
hgnc
HGNC:28428
resolver
uniprot
A1DZ74
resolver
uniprot
B3KVH8
resolver
uniprot
B4DLK6
resolver
uniprot
D3DTN4
resolver
uniprot
I3L1N0
resolver
uniprot
Q8IZK0
resolver
uniprot
Q96HG7
resolver
uniprot
Q9H5X0
resolver
uniprot_entry
I3L1N0_HUMAN
resolver
uniprot_entry
PHF23_HUMAN
resolver
uniprot_sec
A1DZ74
resolver
uniprot_sec
B3KVH8
resolver
uniprot_sec
B4DLK6
resolver
uniprot_sec
D3DTN4
resolver
uniprot_sec
Q8IZK0
resolver
uniprot_sec
Q96HG7
resolver
uniprot_sec
Q9H5X0
resolver
amino_acid_sequence
MLEAMAEPSPEDPPPTLKPETQPPEKRRRTIEDFNKFCSFVLAYAGYIPPSKEESDWPASGSSSPLRGESAADSDGWDSAPSDLRTIQTFVKKAKSSKRRAAQAGPTQPGPPRSTFSRLQAPDSATLLEKMKLKDSLFDLDGPKVASPLSPTSLTHTSRPPAALTPVPLSQGDLSHPPRKKDRKNRKLGPGAGAGFGVLRRPRPTPGDGEKRSRIKKSKKRKLKKAERGDRLPPPGPPQAPPSDTDSEEEEEEEEEEEEEEMATVVGGEAPVPVLPTPPEAPRPPATVHPEGVPPADSESKEVGSTETSQDGDASSSEGEMRVMDEDIMVESGDDSWDLITCYCRKPFAGRPMIECSLCGTWIHLSCAKIKKTNVPDFFYCQKCKELRPEARRLGGPPKSGEP
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving PHF23 is found in a patient with acute myeloid leukemia (AML). Translocation t(11;17)(p15;p13) with NUP98.
uniprot
proteins
function
FUNCTION: Acts as a negative regulator of autophagy, through promoting ubiquitination and degradation of LRSAM1, an E3 ubiquitin ligase that promotes autophagy in response to starvation or infecting bacteria. {ECO:0000269|PubMed:25484098}.
uniprot
proteins
mass_dalton
43818
uniprot
proteins
protein_family
PHF23 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17287853
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25484098
uniprot
proteins
sequence_length
403
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:25484098}. Cytoplasm {ECO:0000269|PubMed:25484098}. Note=Mainly present in the nucleus and part in the cytoplasm. {ECO:0000269|PubMed:25484098}.
uniprot
proteins