Slc9a9
entrez
331004
canonical
uniprot
Q8BZ00
canonical
ensembl
ENSMUSG00000031129
resolver
ensp
ENSMUSP00000033463
resolver
enst
ENSMUST00000033463
resolver
genesymbol
Slc9a9
resolver
genesymbol_syn
Nhe9
resolver
uniprot
Q3U0X0
resolver
uniprot_entry
SL9A9_MOUSE
resolver
uniprot_sec
Q3U0X0
resolver
amino_acid_sequence
MAGQLRFTSGKDEDHFQHQGAVELLAFNFLLILTILTIWLFKNHRFRFLHETGGAMVYGLIMGLILRYATAPTDIDSGTVYNCGNLFFSPSTLLVNITDQVYEYKYQREINQHNISPHQGNAILEKMTFDPEIFFNVLLPPIIFHAGYSLKKRHFFQNLGSILTYAFLGTAISCVVIGLIMYGFVKAMVHAGQLKSGDFHFTDCLFFGSLMSATDPVTVLAIFHELHVDPDLYTLLFGESVLNDAVAIVLTYSISIYSPKENPNAFDTAAFFQSVGNFLGIFAGSFAMGSAYAVVTALLTKFTKLREFPMLETGLFFLLSWSAFLSAEAAGLTGIVAVLFCGVTQAHYTYNNLSSDSKLRTKQLFEFMNFLAENVIFCYMGLALFTFQNHIFNALFILGAFLAIFVARACNIYPLSFLLNLGRKQKIPWNFQHMMMFSGLRGAIAFALAIRNTESQPKQMMFTTTLLLVFFTVWVFGGGTTPMLTWLQIRVGVDLDESLKEEPSSQQEANKLDKNMTKTESAQLFRMWYGFDHKYLKPILTHSGPPLTTTLPAWCGPVSRLLTSPQAYGEQLKEDDVECIVNQDELAMNYQEQSPSPSSPTTKLALDQKSSGQTPGKENIYEGDLGLGGYDLKLEQTRGQPQMD
uniprot
proteins
function
FUNCTION: Endosomal Na(+), K(+)/H(+) antiporter. Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+) (PubMed:17005858). By facilitating proton efflux, SLC9A9 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Regulates organellar pH and consequently, endosome maturation and endocytic trafficking of plasma membrane receptors and neurotransporters (PubMed:24065030, PubMed:29362376). Promotes the recycling of transferrin receptors back to the cell surface to facilitate additional iron uptake in the brain (By similarity). Regulates synaptic transmission by regulating the luminal pH of axonal endosomes (PubMed:29362376). Regulates phagosome lumenal pH, thus affecting phagosome maturation, and consequently, microbicidal activity in macrophages (PubMed:35716776). Can also be active at the cell surface of specialized cells, e.g., in the inner ear hair bundles uses the high K(+) of the endolymph to regulate intracellular pH (PubMed:17005858). {ECO:0000250|UniProtKB:Q8IVB4, ECO:0000269|PubMed:17005858, ECO:0000269|PubMed:24065030, ECO:0000269|PubMed:29362376, ECO:0000269|PubMed:35716776}.
uniprot
proteins
mass_dalton
72133
uniprot
proteins
mutagenesis
MUTAGEN 236; /note="L->S: Does not rescue the hyperacidication of axonal vesicles as well as Ca2(+) influx in response to single action potential in neurons from Slc9a9-deficient mice."; /evidence="ECO:0000269|PubMed:29362376
uniprot
proteins
protein_family
Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17005858
uniprot
proteins
pubmed
24065030
uniprot
proteins
pubmed
26755066
uniprot
proteins
pubmed
29362376
uniprot
proteins
pubmed
35716776
uniprot
proteins
sequence_length
644
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250|UniProtKB:Q8IVB4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F7B113}. Cell membrane {ECO:0000269|PubMed:17005858}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F7B113}. Early endosome membrane {ECO:0000269|PubMed:24065030, ECO:0000269|PubMed:29362376}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F7B113}. Recycling endosome membrane {ECO:0000269|PubMed:24065030, ECO:0000269|PubMed:29362376}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F7B113}. Cytoplasmic vesicle, phagosome membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:F7B113}. Note=Localized to the plasma membrane in inner ear hair cell bundle (PubMed:17005858). Interacts with CHP1 (By similarity). {ECO:0000250|UniProtKB:D4A7H1, ECO:0000269|PubMed:17005858}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..41; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 46..66; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 127..147; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 165..185; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 204..224; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 236..256; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 278..298; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 310..327; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 334..350; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 365..385; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 387..407; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 430..450; /note="Helical; Name=12"; /evidence="ECO:0000255"; TRANSMEM 466..486; /note="Helical; Name=13"; /evidence="ECO:0000255
uniprot
proteins