Ctf1
entrez
13019
canonical
uniprot
Q60753
canonical
ensembl
ENSMUSG00000042340
resolver
ensp
ENSMUSP00000049161
resolver
ensp
ENSMUSP00000145586
resolver
ensp
ENSMUSP00000190673
resolver
ensp
ENSMUSP00000190674
resolver
ensp
ENSMUSP00000190675
resolver
enst
ENSMUST00000047393
resolver
enst
ENSMUST00000206506
resolver
genesymbol
Ctf1
resolver
uniprot
A0A0U1RNJ2
resolver
uniprot
Q541U3
resolver
uniprot_entry
A0A0U1RNJ2_MOUSE
resolver
uniprot_entry
CTF1_MOUSE
resolver
uniprot_entry
Q541U3_MOUSE
resolver
amino_acid_sequence
MSQREGSLEDHQTDSSISFLPHLEAKIRQTHNLARLLTKYAEQLLEEYVQQQGEPFGLPGFSPPRLPLAGLSGPAPSHAGLPVSERLRQDAAALSVLPALLDAVRRRQAELNPRAPRLLRSLEDAARQVRALGAAVETVLAALGAAARGPGPEPVTVATLFTANSTAGIFSAKVLGFHVCGLYGEWVSRTEGDLGQLVPGGVA
uniprot
proteins
function
FUNCTION: Functions as a cytokine that binds to the LIF receptor complex (PubMed:7738033, PubMed:9030543). The LIF receptor complex indeed consists of two signaling receptor subunits IL6ST/gp130 and LIFR that transduce the signal into the cell (PubMed:7738033, PubMed:9030543). Functionally, acts as a potent cardiac survival factor, and promotes cardiomyocyte proliferation and hypertrophy (PubMed:7862649, PubMed:8625793, PubMed:9050750). Mechanistically, ligand binding to LIFR, induces heterodimerization with IL6ST/gp130 activating JAK tyrosine kinases (JAK1 or JAK2 and to a lesser extent TYK2) bound to their intracellular domains (PubMed:9030543). These kinases subsequently phosphorylate IL6ST/gp130 and LIFR (PubMed:9030543). The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducer and activator of transcription STAT3 (PubMed:9030543). {ECO:0000269|PubMed:7738033, ECO:0000269|PubMed:7862649, ECO:0000269|PubMed:8625793, ECO:0000269|PubMed:9030543, ECO:0000269|PubMed:9050750}.
uniprot
proteins
mass_dalton
21509
uniprot
proteins
protein_family
IL-6 superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7738033
uniprot
proteins
pubmed
7862649
uniprot
proteins
pubmed
8625793
uniprot
proteins
pubmed
9030543
uniprot
proteins
pubmed
9050750
uniprot
proteins
sequence_length
203
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q16619}.
uniprot
proteins