Reg3a
entrez
171162
canonical
uniprot
P35231
canonical
ensembl
ENSRNOG00000006360
resolver
ensp
ENSRNOP00000008468
resolver
enst
ENSRNOT00000008468
resolver
genesymbol
Reg3a
resolver
genesymbol_syn
Pap2
resolver
genesymbol_syn
Reg3
resolver
uniprot
A0A0G2JSI6
resolver
uniprot_entry
A0A0G2JSI6_RAT
resolver
uniprot_entry
REG3A_RAT
resolver
amino_acid_sequence
MLPRLSFNNVSWTLLYYLFIFQVRGEDSQKAVPSTRTSCPMGSKAYRSYCYTLVTTLKSWFQADLACQKRPSGHLVSILSGGEASFVSSLVTGRVNNNQDIWIWLHDPTMGQQPNGGGWEWSNSDVLNYLNWDGDPSSTVNRGNCGSLTATSEFLKWGDHHCDVELPFVCKFKQ
uniprot
proteins
disease_involvement
DISEASE: Note=Overexpressed during the acute phase of pancreatitis.
uniprot
proteins
function
FUNCTION: Bactericidal C-type lectin. The lack of the EPN motif may explain its inability to bind peptidoglycan. {ECO:0000250|UniProtKB:O09037}.; FUNCTION: Acts as a hormone in response to different stimuli like anti-inflammatory signals, such as IL17A, or gut microbiome. Secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways. Induced by IL17A in keratinocytes, regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. In parallel, inhibits skin inflammation through the inhibition of inflammatory cytokines such as IL6 and TNF. In pancreas, is able to permealize beta-cells membrane and stimulate their proliferation. {ECO:0000250|UniProtKB:Q06141}.
uniprot
proteins
mass_dalton
19599
uniprot
proteins
post_translational_modification
PTM: Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity. {ECO:0000250|UniProtKB:Q06141}.
uniprot
proteins
pubmed
8039722
uniprot
proteins
pubmed
8369291
uniprot
proteins
sequence_length
174
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q06141}. Note=Found in the apical region of pancreatic acinar cells. {ECO:0000250|UniProtKB:Q06141}.
uniprot
proteins