Lamtor3
entrez
56692
canonical
uniprot
O88653
canonical
ensembl
ENSMUSG00000091512
resolver
ensp
ENSMUSP00000130811
resolver
ensp
ENSMUSP00000142512
resolver
enst
ENSMUST00000168345
resolver
enst
ENSMUST00000197064
resolver
genesymbol
Lamtor3
resolver
genesymbol_syn
Map2k1ip1
resolver
genesymbol_syn
Mapbp
resolver
genesymbol_syn
Mapksp1
resolver
uniprot
Q542I7
resolver
uniprot_entry
LTOR3_MOUSE
resolver
uniprot_entry
Q542I7_MOUSE
resolver
amino_acid_sequence
MADDLKRFLYKKLPSVEGLHAIVVSDRDGVPVIKVANDSAPEHALRPGFLSTFALATDQGSKLGLSKNKSIICYYNTYQVVQFNRLPLVVSFIASSSANTGLIVSLEKELAPLFEELIKVVEVS
uniprot
proteins
function
FUNCTION: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:15263099). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (By similarity). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (By similarity). Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2 (PubMed:9733512). {ECO:0000250|UniProtKB:Q9UHA4, ECO:0000269|PubMed:15263099, ECO:0000269|PubMed:9733512}.
uniprot
proteins
mass_dalton
13553
uniprot
proteins
protein_family
LAMTOR3 family
uniprot
proteins
pubmed
11266467
uniprot
proteins
pubmed
15118098
uniprot
proteins
pubmed
15263099
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19177150
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9733512
uniprot
proteins
sequence_length
124
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:15263099, ECO:0000269|PubMed:19177150}; Peripheral membrane protein {ECO:0000269|PubMed:15263099, ECO:0000269|PubMed:19177150}; Cytoplasmic side {ECO:0000269|PubMed:15263099, ECO:0000269|PubMed:19177150}. Note=Recruited to lysosome and endosome membranes by LAMTOR1. {ECO:0000269|PubMed:19177150}.
uniprot
proteins