Abcb10
entrez
56199
canonical
uniprot
Q9JI39
canonical
ensembl
ENSMUSG00000031974
resolver
ensp
ENSMUSP00000075011
resolver
enst
ENSMUST00000075578
resolver
genesymbol
Abcb10
resolver
uniprot
Q542P7
resolver
uniprot
Q9D0C7
resolver
uniprot_entry
ABCBA_MOUSE
resolver
uniprot_sec
Q542P7
resolver
uniprot_sec
Q9D0C7
resolver
activity_regulation
ACTIVITY REGULATION: Oxidized glutathione (GSSG) stimulates ATP hydrolysis without affecting ATP binding, whereas reduced glutathione (GSH) inhibits ATP binding and hydrolysis. {ECO:0000269|PubMed:26053025}.
uniprot
proteins
amino_acid_sequence
MRAPSARALLLIPRRGPAVRAWAPAVSSRIWLASEWTPLVRAWTSLIHKPGSGLRFPAPLSGLPGGVGQWATSSGARRCWVLAGPRAAHPLFARLQGAAATGVRDLGNDSQRRPAATGRSEVWKLLGLVRPERGRLSAAVGFLAVSSVITMSAPFFLGRIIDVIYTNPSEGYGDSLTRLCAVLTCVFLCGAAANGIRVYLMQSSGQSIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGVGMMFFVSPSLATFVLSVVPPISVLAVIYGRYLRKLSKATQDSLAEATQLAEERIGNIRTIRAFGKEMTEVEKYTGRVDQLLQLAQKEALARAGFFGAAGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGLSIGGLSSFYSELMKGLGAGGRLWELLERQPRLPFNEGMVLDEKTFQGALEFRNVHFTYPARPEVSVFQDFSLSIPSGSVTALVGPSGSGKSTVVSLLLRLYDPNSGTVSLDGHDIRQLNPVWLRSKIGTVSQEPVLFSCSVAENIAYGADNLSSVTAQQVERAAEVANAAEFIRSFPQGFDTVVGEKGILLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEHLVQEALDRLMEGRTVLIIAHRLSTIKNANFVAVLDHGKICEHGTHEELLLKPNGLYRKLMNKQSFLSYNGAEQFLEPARA
uniprot
proteins
ec_number
7.6.2.-
uniprot
proteins
function
FUNCTION: ATP-dependent transporter located in the mitochondrial inner membrane that catalyzes the export of biliverdin from the mitochondrial matrix, and plays a crucial role in hemoglobin synthesis and antioxidative stress (PubMed:22240895, PubMed:24421385, PubMed:26053025, PubMed:28808058, PubMed:34011630). Participates in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX) (PubMed:24421385, PubMed:28808058). Involved in the stabilization of the iron transporter mitoferrin-1/SLC25A37 (PubMed:19805291). In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria (By similarity). {ECO:0000250|UniProtKB:Q9NRK6, ECO:0000269|PubMed:19805291, ECO:0000269|PubMed:22240895, ECO:0000269|PubMed:24421385, ECO:0000269|PubMed:26053025, ECO:0000269|PubMed:28808058, ECO:0000269|PubMed:34011630}.
uniprot
proteins
mass_dalton
77188
uniprot
proteins
mutagenesis
MUTAGEN 497; /note="G->A: Decreases ATP binding about 50%."; /evidence="ECO:0000269|PubMed:26053025"; MUTAGEN 498; /note="K->R: Decreases ATP binding about 50%."; /evidence="ECO:0000269|PubMed:26053025"; MUTAGEN 547; /note="C->A: Does not affect ABCB10 glutathionylation."; /evidence="ECO:0000269|PubMed:26053025"; MUTAGEN 602; /note="G->D: Affects ATP hydrolysis but not binding."; /evidence="ECO:0000269|PubMed:26053025"; MUTAGEN 602; /note="G->V: Affects ATP hydrolysis but not binding."; /evidence="ECO:0000269|PubMed:26053025"; MUTAGEN 624; /note="E->Q: Affects ATP hydrolysis but not binding."; /evidence="ECO:0000269|PubMed:26053025"; MUTAGEN 675; /note="C->A: Prevents ABCB10 glutathionylation."; /evidence="ECO:0000269|PubMed:26053025
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCB family
uniprot
proteins
protein_family
Mitochondrial peptide exporter (TC 3.A.1.212) subfamily
uniprot
proteins
pubmed
10835348
uniprot
proteins
pubmed
15215243
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19805291
uniprot
proteins
pubmed
20427704
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22240895
uniprot
proteins
pubmed
24421385
uniprot
proteins
pubmed
26053025
uniprot
proteins
pubmed
28808058
uniprot
proteins
pubmed
30765471
uniprot
proteins
pubmed
34011630
uniprot
proteins
sequence_length
715
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:10835348}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NRK6}.
uniprot
proteins
transmembrane_region
TRANSMEM 134..157; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NRK6"; TRANSMEM 179..201; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NRK6"; TRANSMEM 253..275; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NRK6"; TRANSMEM 279..298; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NRK6"; TRANSMEM 358..381; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NRK6"; TRANSMEM 396..417; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NRK6
uniprot
proteins