Haspin
entrez
14841
canonical
uniprot
Q9Z0R0
canonical
ensembl
ENSMUSG00000050107
resolver
ensp
ENSMUSP00000055806
resolver
enst
ENSMUST00000052140
resolver
genesymbol
Haspin
resolver
genesymbol_syn
Gsg2
resolver
uniprot
A0A0R4J0P2
resolver
uniprot
Q99MU9
resolver
uniprot
Q9JJJ4
resolver
uniprot_entry
A0A0R4J0P2_MOUSE
resolver
uniprot_entry
HASP_MOUSE
resolver
uniprot_sec
Q99MU9
resolver
uniprot_sec
Q9JJJ4
resolver
activity_regulation
ACTIVITY REGULATION: Constitutive activity that does not require phosphorylation. Specifically inhibited by 3-(1H-indazol-5-yl)-N-propylimidazo[1,2-b]pyridazin-6-amine (CHR-6494). {ECO:0000250|UniProtKB:Q8TF76}.
uniprot
proteins
amino_acid_sequence
MAQAHPRSGTRLFRTYAARGVRGSQRQPGGLAEQWFQPPNLKRAFSSSLSDSNESPAVASDDPDDPDFPGSLVGQRRRRPRGSGSRNQRTLTNTPRVQRLRPRPPQKCSTPCSRLRPPPFPNCSPGCLGSDHSVCIQSRDSNELGTSASLFSSPASPGAPDPLYADSAVPGSFHLPAASLSEPSVPCPQVAATGDRYTGRALRAEASFRSSLFSLVNSGATEENKFGTDGENVKESCCERRQQMGNRLTDPDLTSPGKRKAACKKVVSQGVDQRDYEESSACKDLRVPGEISRPKRTGPLRKRKQQEATGTPPRHYHQSKKKRKASVSLWNLNTSQRDSWTKTRASFGFHKKKIITSVIEVCSSVASSSSRSLLSECSTPPIKNRAHLTVSSRCSSVYLLSPLKTLHVTDQRPSYAEKVYGECNQEGPIPFSDCLSTEKLERCEKIGEGVFGEVFQIINDQAPVALKIIAIEGLDLVNGSHQKTFEEILPEIIISKELSLLSSEAYNRTEGFIGLNSVHCVQGLYPPLLLKAWDHYNTTKRSANDRPDFFQEDQLFIILEFEFGGVDLERMKTKLSSVATAKSILHQITASLAVAEASLHFEHRDLHWGNVLLKKTNLKELRYTLNGKTSTIPTHGLQVNIIDYTLSRLERDGIVVFCDISAEEDLFTGEGDYQFEIYRLMRKENKNCWGEYHPYNNVLWLHYLTDKILNKMKFKTKCQSAAMKQIRKNLQHFHRTVLSFSSATDLLCQHSLFR
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle. {ECO:0000250|UniProtKB:Q8TF76}.
uniprot
proteins
mass_dalton
84181
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated on both serine and threonine residues (By similarity). Strongly phosphorylated during mitosis but this does not appear to significantly affect its intrinsic kinase activity. Phosphorylation by AURKB is required for full activity toward histone H3 at 'Ser-3' in mitosis (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q8TF76}.
uniprot
proteins
protein_family
Haspin subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Ser/Thr protein kinase family
uniprot
proteins
pubmed
10358056
uniprot
proteins
pubmed
11311555
uniprot
proteins
pubmed
11311556
uniprot
proteins
pubmed
15681610
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7957958
uniprot
proteins
sequence_length
754
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10358056}. Chromosome {ECO:0000250|UniProtKB:Q8TF76}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q8TF76}. Note=Nuclear during interphase and associates with the chromosomes and spindle apparatus during mitosis. {ECO:0000250|UniProtKB:Q8TF76}.
uniprot
proteins