PSMG2
entrez
56984
canonical
uniprot
Q969U7
canonical
ensembl
ENSG00000128789
resolver
ensp
ENSP00000325919
resolver
ensp
ENSP00000476763
resolver
genesymbol
PSMG2
resolver
genesymbol_syn
HCCA3
resolver
genesymbol_syn
PAC2
resolver
genesymbol_syn
TNFSF5IP1
resolver
hgnc
HGNC:24929
resolver
uniprot
B0YJB3
resolver
uniprot
Q6IAH4
resolver
uniprot
Q9NRV1
resolver
uniprot
Q9P1R6
resolver
uniprot
V9GYH7
resolver
uniprot_entry
PSMG2_HUMAN
resolver
uniprot_entry
Q9P1R6_HUMAN
resolver
uniprot_sec
B0YJB3
resolver
uniprot_sec
Q6IAH4
resolver
uniprot_sec
Q9NRV1
resolver
uniprot_sec
V9GYH7
resolver
amino_acid_sequence
MFVPCGESAPDLAGFTLLMPAVSVGNVGQLAMDLIISTLNMSKIGYFYTDCLVPMVGNNPYATTEGNSTELSINAEVYSLPSRKLVALQLRSIFIKYKSKPFCEKLLSWVKSSGCARVIVLSSSHSYQRNDLQLRSTPFRYLLTPSMQKSVQNKIKSLNWEEMEKSRCIPEIDDSEFCIRIPGGGITKTLYDESCSKEIQMAVLLKFVSEGDNIPDALGLVEYLNEWLQILKPLSDDPTVSASRWKIPSSWRLLFGSGLPPALF
uniprot
proteins
disease_involvement
DISEASE: Proteasome-associated autoinflammatory syndrome 4 (PRAAS4) [MIM:619183]: An autosomal recessive, autoinflammatory disorder characterized by panniculitis and erythematous skin lesions apparent in early infancy. Additional features include hepatosplenomegaly, lymphadenopathy, autoimmune hemolytic anemia, fever, generalized lipodystrophy, myositis, joint contractures, and mild motor and speech delay. {ECO:0000269|PubMed:30664889}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization. {ECO:0000269|PubMed:16251969, ECO:0000269|PubMed:17707236}.
uniprot
proteins
mass_dalton
29396
uniprot
proteins
post_translational_modification
PTM: Degraded by the proteasome upon completion of 20S proteasome maturation. {ECO:0000269|PubMed:16251969}.
uniprot
proteins
protein_family
PSMG2 family
uniprot
proteins
pubmed
11854909
uniprot
proteins
pubmed
11920191
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
16251969
uniprot
proteins
pubmed
17707236
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26109405
uniprot
proteins
pubmed
30664889
uniprot
proteins
sequence_length
264
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9EST4}.
uniprot
proteins