FCHSD2
entrez
9873
canonical
uniprot
O94868
canonical
ensembl
ENSG00000137478
resolver
ensp
ENSP00000308978
resolver
ensp
ENSP00000386722
resolver
ensp
ENSP00000745106
resolver
genesymbol
FCHSD2
resolver
genesymbol_syn
KIAA0769
resolver
genesymbol_syn
SH3MD3
resolver
hgnc
HGNC:29114
resolver
uniprot
B4DNI3
resolver
uniprot
Q7L8J9
resolver
uniprot
Q8WVM2
resolver
uniprot
Q96FV7
resolver
uniprot
Q9UF77
resolver
uniprot_entry
FCSD2_HUMAN
resolver
uniprot_sec
B4DNI3
resolver
uniprot_sec
Q7L8J9
resolver
uniprot_sec
Q8WVM2
resolver
uniprot_sec
Q96FV7
resolver
uniprot_sec
Q9UF77
resolver
amino_acid_sequence
MQPPPRKVKVTQELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRNDYRSMYPVWKSFLEGTMQVAQSRMNICENYKNFISEPARTVRSLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFLLENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTSRQLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRVLNDLECHGAAVSEQSRAELEQKIDEARENIRKAEIIKLKAEARLDLLKQIGVSVDTWLKSAMNQVMEELENERWARPPAVTSNGTLHSLNADTEREEGEEFEDNMDVFDDSSSSPSGTLRNYPLTCKVVYSYKASQPDELTIEEHEVLEVIEDGDMEDWVKARNKVGQVGYVPEKYLQFPTSNSLLSMLQSLAALDSRSHTSSNSTEAELVSGSLNGDASVCFVKALYDYEGQTDDELSFPEGAIIRILNKENQDDDGFWEGEFNGRIGVFPSVLVEELSASENGDTPWMREIQISPSPKPHASLPPLPLYDQPPSSPYPSPDKRSSLYFPRSPSANEKSLHAESPGFSQASRHTPETSYGKLRPVRAAPPPPTQNHRRPAEKIEDVEITLV
uniprot
proteins
function
FUNCTION: Adapter protein that plays a role in endocytosis via clathrin-coated pits. Contributes to the internalization of cell surface receptors, such as integrin ITGB1 and transferrin receptor (PubMed:29887380). Promotes endocytosis of EGFR in cancer cells, and thereby contributes to the down-regulation of EGFR signaling (PubMed:30249660). Recruited to clathrin-coated pits during a mid-to-late stage of assembly, where it is required for normal progress from U-shaped intermediate stage pits to terminal, omega-shaped pits (PubMed:29887380). Binds to membranes enriched in phosphatidylinositol 3,4-bisphosphate or phosphatidylinositol 3,4,5-trisphosphate (PubMed:29887380). When bound to membranes, promotes actin polymerization via its interaction with WAS and/or WASL which leads to the activation of the Arp2/3 complex. Does not promote actin polymerization in the absence of membranes (PubMed:29887380). {ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}.
uniprot
proteins
mass_dalton
84276
uniprot
proteins
mutagenesis
MUTAGEN 478; /note="Y->A: Loss of ability to promote actin polymerization; when associated with A-480."; /evidence="ECO:0000269|PubMed:29887380"; MUTAGEN 480; /note="Y->A: Loss of ability to promote actin polymerization; when associated with A-478."; /evidence="ECO:0000269|PubMed:29887380"; MUTAGEN 521; /note="P->A: Loss of ability to promote actin polymerization; when associated with A-524."; /evidence="ECO:0000269|PubMed:29887380"; MUTAGEN 524; /note="Y->A: Loss of ability to promote actin polymerization; when associated with A-521."; /evidence="ECO:0000269|PubMed:29887380"; MUTAGEN 576; /note="Y->S: Abolishes interaction with ITSN1 and location at clathrin-coated pits; when associated with S-607."; /evidence="ECO:0000269|PubMed:29887380"; MUTAGEN 607; /note="F->S: Abolishes interaction with ITSN1 and location at clathrin-coated pits; when associated with S-576."; /evidence="ECO:0000269|PubMed:29887380"; MUTAGEN 622..623; /note="VL->KK: Abolishes interaction with ITSN1."; /evidence="ECO:0000269|PubMed:29887380"; MUTAGEN 681; /note="S->A: Impaired recruitment to the cell membrane."; /evidence="ECO:0000269|PubMed:30249660"; MUTAGEN 681; /note="S->E: Increased recruitment to the cell membrane."; /evidence="ECO:0000269|PubMed:30249660
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation on a Ser residue is important for recruitment to the cell membrane and for its role in promoting endocytosis. {ECO:0000269|PubMed:30249660}.
uniprot
proteins
pubmed
14627983
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15067381
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29887380
uniprot
proteins
pubmed
30249660
uniprot
proteins
pubmed
9872452
uniprot
proteins
sequence_length
740
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q3USJ8}. Cell junction {ECO:0000269|PubMed:14627983}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}. Cell membrane {ECO:0000269|PubMed:14627983, ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}; Peripheral membrane protein {ECO:0000269|PubMed:14627983, ECO:0000269|PubMed:30249660}; Cytoplasmic side {ECO:0000269|PubMed:14627983, ECO:0000269|PubMed:30249660}. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q3USJ8}. Note=Partially localized at clathrin-coated pits at the cell membrane (PubMed:30249660). Detected at the cell membrane at sites around clathrin-coated pits, very close to the clathrin-coated pits but not an intrinsic part of the clathrin-coated pits (PubMed:29887380). Colocalizes at cell-cell contacts with CDH1, but is not detected at tight junctions (PubMed:14627983). {ECO:0000269|PubMed:14627983, ECO:0000269|PubMed:29887380, ECO:0000269|PubMed:30249660}.
uniprot
proteins