Adcy3
entrez
104111
canonical
uniprot
Q8VHH7
canonical
ensembl
ENSMUSG00000020654
resolver
ensp
ENSMUSP00000020984
resolver
ensp
ENSMUSP00000115406
resolver
ensp
ENSMUSP00000115644
resolver
ensp
ENSMUSP00000122073
resolver
ensp
ENSMUSP00000218214
resolver
ensp
ENSMUSP00000218218
resolver
enst
ENSMUST00000020984
resolver
enst
ENSMUST00000124505
resolver
enst
ENSMUST00000127756
resolver
enst
ENSMUST00000152065
resolver
genesymbol
Adcy3
resolver
genesymbol_syn
mKIAA0511
resolver
uniprot
B8JK56
resolver
uniprot
B8JK57
resolver
uniprot
Q80TY9
resolver
uniprot_entry
ADCY3_MOUSE
resolver
uniprot_entry
B8JK56_MOUSE
resolver
uniprot_entry
Q80TY9_MOUSE
resolver
uniprot_sec
B8JK57
resolver
activity_regulation
ACTIVITY REGULATION: Specifically activated by the G alpha protein GNAL/G(olf) in signaling cascades triggered by odorant receptors (By similarity). Specifically activated by the G alpha protein GNAS/G(s) in primary cilia (PubMed:40472089). Activated by forskolin (PubMed:11055432, PubMed:25329148). After forskolin treatment, activity is further increased by calcium/calmodulin. In the absence of forskolin, calcium/calmodulin has little effect on enzyme activity (By similarity). {ECO:0000250|UniProtKB:P21932, ECO:0000269|PubMed:11055432, ECO:0000269|PubMed:25329148, ECO:0000269|PubMed:40472089}.
uniprot
proteins
amino_acid_sequence
MPRNQGFSDPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPESLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLAPLMVAGFGLVLDIILFVLCKKGLLPDRVSRKVVPYLLWLLISAQIFSYLGLNFSRAHAASDTVGWQAFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQDELEGMQLLREILANVFLYLCAIIVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLDEKGIETYLIIASKPEVKKTAQNGLNGSAVPNGAPASSKPSSPALIETKEPNGSAHASGSTSEEAEEQEAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLTMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLFCTAMVEILIDPWLMTNYVTFVVGEVLLLILTICSMAAIFPRSFPKKLVAFSSWIDRTRWARNTWAMLAIFILVMANVVDMLSCLQYYMGPYNMTAGMELDGGCMENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVTGAVTALNLYAWCPVFDEYDHKRFQEKDSPMVALEKMQVLATPGLNGTDSRLPLVPSKYSMTVMMFVMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQSYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFTSSSKEEKSDKERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDRPAAFPNGSSVTLPHQVVDNP
uniprot
proteins
ec_number
4.6.1.1
uniprot
proteins
function
FUNCTION: Catalyzes the formation of the signaling molecule cAMP in response to G protein signaling (PubMed:11055432, PubMed:25329148, PubMed:40472089, PubMed:9768837). Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis: specifically activated by G alpha protein GNAL/G(olf) in olfactory epithelium (PubMed:11055432, PubMed:9768837). Required for the perception of odorants (PubMed:11055432). Mediates signaling cascades in primary cilia: specifically activated by G alpha protein GNAS/G(s) in primary cilia (PubMed:40472089). Plays a role in regulating food intake and body fat accumulation in the paraventricular nucleus of the hypothalamus (PVH) by acting downstream of MC4R activation (PubMed:40472089). Required for normal sperm motility and normal male fertility (PubMed:15705663). {ECO:0000269|PubMed:11055432, ECO:0000269|PubMed:15705663, ECO:0000269|PubMed:25329148, ECO:0000269|PubMed:40472089, ECO:0000269|PubMed:9768837}.
uniprot
proteins
mass_dalton
129085
uniprot
proteins
mutagenesis
MUTAGEN 279; /note="M->I: In Jll; dominant allele that increases enzyme activity, and decreases fasting insulin levels, fasting leptin levels, weight gain and fat accumulation when mice are kept on a high fat diet."; /evidence="ECO:0000269|PubMed:25329148
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:9768837}.; PTM: Rapidly phosphorylated after stimulation by odorants or forskolin. Phosphorylation by CaMK2 at Ser-1077 down-regulates enzyme activity. {ECO:0000269|PubMed:9768837}.; PTM: Sumoylated (PubMed:25908845). Sumoylation is required for targeting of olfactory cilia. {ECO:0000250|UniProtKB:P21932, ECO:0000269|PubMed:25908845}.
uniprot
proteins
protein_family
Adenylyl cyclase class-4/guanylyl cyclase family
uniprot
proteins
pubmed
11055432
uniprot
proteins
pubmed
15705663
uniprot
proteins
pubmed
17924533
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25329148
uniprot
proteins
pubmed
25908845
uniprot
proteins
pubmed
40472089
uniprot
proteins
pubmed
9768837
uniprot
proteins
sequence_length
1145
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:11055432}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium membrane {ECO:0000269|PubMed:11055432, ECO:0000269|PubMed:17924533, ECO:0000269|PubMed:9768837}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus {ECO:0000250|UniProtKB:P21932}. Cytoplasm {ECO:0000250|UniProtKB:O60266}. Note=Localizes to primary cilium. {ECO:0000269|PubMed:17924533}.
uniprot
proteins
transmembrane_region
TRANSMEM 80..100; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 105..125; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 139..159; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 173..193; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 226..246; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 381..401; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 632..652; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 663..683; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 707..727; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 753..773; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 774..794; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 834..854; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins