TRIM17
entrez
51127
canonical
uniprot
Q9Y577
canonical
ensembl
ENSG00000162931
resolver
ensp
ENSP00000295033
resolver
ensp
ENSP00000355658
resolver
ensp
ENSP00000355659
resolver
ensp
ENSP00000403312
resolver
ensp
ENSP00000430468
resolver
ensp
ENSP00000552238
resolver
ensp
ENSP00000552239
resolver
genesymbol
TRIM17
resolver
genesymbol_syn
RBCC
resolver
genesymbol_syn
RNF16
resolver
genesymbol_syn
TERF
resolver
hgnc
HGNC:13430
resolver
uniprot
B3KP04
resolver
uniprot
B4DVJ2
resolver
uniprot
Q5VST8
resolver
uniprot_entry
B3KP04_HUMAN
resolver
uniprot_entry
TRI17_HUMAN
resolver
uniprot_sec
B4DVJ2
resolver
uniprot_sec
Q5VST8
resolver
amino_acid_sequence
MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSFPCPECREMSPQRNLLPNRLLTKVAEMAQQHPGLQKQDLCQEHHEPLKLFCQKDQSPICVVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVKERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQLEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIEVLRGFLEDVVPDATSAYPYLLLYESRQRRYLGSSPEGSGFCSKDRFVAYPCAVGQTAFSSGRHYWEVGMNITGDALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKYLSTFSALTPVMLMEPPSHMGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLGAPKSGQMVISTVTMWVKG
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase that plays important roles in the regulation of neuronal apoptosis, selective autophagy or cell proliferation (PubMed:19358823, PubMed:22023800, PubMed:27562068). Stimulates the degradation of kinetochore ZW10 interacting protein ZWINT in a proteasome-dependent manner, leading to negative regulation of cell proliferation (PubMed:22023800). Inhibits autophagic degradation of diverse known targets while contributing to autophagy of midbodies. Autophagy-inhibitory activity involves MCL1, which TRIM17 assembles into complexes with the key autophagy regulator BECN1 (PubMed:27562068). Controls neuronal apoptosis by mediating ubiquitination and degradation of MCL1 to initiate neuronal death. In addition, regulates NFAT transcription factors NFATC3 and NFATC4 activities by preventing their nuclear localization, thus inhibiting their transcriptional activities. Decreases TRIM41-mediated degradation of ZSCAN2 thereby stimulating alpha-synuclein/SNCA transcription in neuronal cells (By similarity). Prevents the E3 ubiquitin-ligase activity of TRIM28 and its interaction with anti-apoptotic BCL2A1, blocking TRIM28 from ubiquitinating BCL2A1 (PubMed:19358823). {ECO:0000250|UniProtKB:Q7TPM3, ECO:0000269|PubMed:19358823, ECO:0000269|PubMed:22023800, ECO:0000269|PubMed:27562068}.
uniprot
proteins
mass_dalton
54418
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated. {ECO:0000269|PubMed:19358823}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19358823
uniprot
proteins
pubmed
22023800
uniprot
proteins
pubmed
27562068
uniprot
proteins
pubmed
30042493
uniprot
proteins
pubmed
9792805
uniprot
proteins
sequence_length
477
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27562068}. Lysosome {ECO:0000269|PubMed:27562068}.
uniprot
proteins