TPI1
entrez
7167
canonical
uniprot
P60174
canonical
ensembl
ENSG00000111669
resolver
ensp
ENSP00000379933
resolver
ensp
ENSP00000443599
resolver
ensp
ENSP00000484435
resolver
genesymbol
HEL-S-49
resolver
genesymbol
TPI1
resolver
genesymbol_syn
TPI
resolver
hgnc
HGNC:12009
resolver
uniprot
B7Z5D8
resolver
uniprot
D3DUS9
resolver
uniprot
P00938
resolver
uniprot
Q53HE2
resolver
uniprot
Q6FHP9
resolver
uniprot
Q6IS07
resolver
uniprot
Q8WWD0
resolver
uniprot
Q96AG5
resolver
uniprot
V9HWK1
resolver
uniprot_entry
Q53HE2_HUMAN
resolver
uniprot_entry
TPIS_HUMAN
resolver
uniprot_entry
V9HWK1_HUMAN
resolver
uniprot_sec
B7Z5D8
resolver
uniprot_sec
D3DUS9
resolver
uniprot_sec
P00938
resolver
uniprot_sec
Q6FHP9
resolver
uniprot_sec
Q6IS07
resolver
uniprot_sec
Q8WWD0
resolver
uniprot_sec
Q96AG5
resolver
amino_acid_sequence
MAPSRKFFVGGNWKMNGRKQSLGELIGTLNAAKVPADTEVVCAPPTAYIDFARQKLDPKIAVAAQNCYKVTNGAFTGEISPGMIKDCGATWVVLGHSERRHVFGESDELIGQKVAHALAEGLGVIACIGEKLDEREAGITEKVVFEQTKVIADNVKDWSKVVLAYEPVWAIGTGKTATPQQAQEVHEKLRGWLKSNVSDAVAQSTRIIYGGSVTGATCKELASQPDVDGFLVGGASLKPEFVDIINAKQ
uniprot
proteins
disease_involvement
DISEASE: Triosephosphate isomerase deficiency (TPID) [MIM:615512]: An autosomal recessive multisystem disorder characterized by congenital hemolytic anemia, progressive neuromuscular dysfunction, susceptibility to bacterial infection, and cardiomyopathy. {ECO:0000269|PubMed:2876430, ECO:0000269|PubMed:8503454, ECO:0000269|PubMed:8571957, ECO:0000269|PubMed:9338582, ECO:0000269|Ref.37}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
4.2.3.3
uniprot
proteins
ec_number
5.3.1.1
uniprot
proteins
function
FUNCTION: Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. {ECO:0000269|PubMed:18562316}.; FUNCTION: It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids. {ECO:0000250|UniProtKB:P00939}.
uniprot
proteins
mass_dalton
26669
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1. {ECO:0000255|PROSITE-ProRule:PRU10127}.; PATHWAY: Carbohydrate biosynthesis; gluconeogenesis. {ECO:0000255|PROSITE-ProRule:PRU10127}.
uniprot
proteins
protein_family
Triosephosphate isomerase family
uniprot
proteins
pubmed
1339398
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16511037
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
16807684
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17693683
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
18562316
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22905912
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
2579079
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
2876430
uniprot
proteins
pubmed
2925688
uniprot
proteins
pubmed
4022011
uniprot
proteins
pubmed
6434534
uniprot
proteins
pubmed
8061610
uniprot
proteins
pubmed
8503454
uniprot
proteins
pubmed
8571957
uniprot
proteins
pubmed
8723724
uniprot
proteins
pubmed
9074930
uniprot
proteins
pubmed
9150946
uniprot
proteins
pubmed
9150948
uniprot
proteins
pubmed
9338582
uniprot
proteins
sequence_length
249
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU10127}.
uniprot
proteins