Rab14
entrez
94197
canonical
uniprot
P61107
canonical
ensembl
ENSRNOG00000071747
resolver
ensp
ENSRNOP00000110207
resolver
enst
ENSRNOT00000136919
resolver
genesymbol
Rab14
resolver
uniprot
A0ABK0LXD4
resolver
uniprot
B0BMW0
resolver
uniprot
P35287
resolver
uniprot
Q969L0
resolver
uniprot
Q9UI11
resolver
uniprot_entry
A0ABK0LXD4_RAT
resolver
uniprot_entry
B0BMW0_RAT
resolver
uniprot_entry
RAB14_RAT
resolver
uniprot_sec
P35287
resolver
uniprot_sec
Q969L0
resolver
uniprot_sec
Q9UI11
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) including DENND6A and DENND6B which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs) which prevent Rab-GDP dissociation. {ECO:0000250|UniProtKB:P61106}.
uniprot
proteins
amino_acid_sequence
MATTPYNYSYIFKYIIIGDMGVGKSCLLHQFTEKKFMADCPHTIGVEFGTRIIEVSGQKIKLQIWDTAGQERFRAVTRSYYRGAAGALMVYDITRRSTYNHLSSWLTDARNLTNPNTVIILIGNKADLEAQRDVTYEEAKQFAEENGLLFLEASAKTGENVEDAFLEAAKKIYQNIQDGSLDLNAAESGVQHKPSAPQGGRLTSEPQPQREGCGC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB14 is involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development (PubMed:15004230). Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion. Mediates endosomal tethering and fusion through the interaction with RUFY1 and RAB4B (By similarity). Interaction with RAB11FIP1 may function in the process of neurite formation (By similarity). {ECO:0000250|UniProtKB:P61106, ECO:0000250|UniProtKB:Q91V41, ECO:0000269|PubMed:15004230}.
uniprot
proteins
mass_dalton
23927
uniprot
proteins
mutagenesis
MUTAGEN 25; /note="S->N: Mimicks the GTP-bound state and is enriched in the Golgi region."; /evidence="ECO:0000269|PubMed:15004230"; MUTAGEN 70; /note="Q->L: Mimicks the GDP-bound state."; /evidence="ECO:0000269|PubMed:15004230"; MUTAGEN 124; /note="N->I: Enriched in the Golgi region."; /evidence="ECO:0000269|PubMed:15004230
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
1313420
uniprot
proteins
pubmed
15004230
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
215
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Recycling endosome {ECO:0000250|UniProtKB:P61106}. Early endosome membrane {ECO:0000269|PubMed:15004230}; Lipid-anchor {ECO:0000305|PubMed:15004230}; Cytoplasmic side {ECO:0000305|PubMed:15004230}. Golgi apparatus membrane {ECO:0000269|PubMed:15004230}; Lipid-anchor {ECO:0000305|PubMed:15004230}; Cytoplasmic side {ECO:0000305|PubMed:15004230}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:15004230}; Lipid-anchor {ECO:0000305|PubMed:15004230}; Cytoplasmic side {ECO:0000305|PubMed:15004230}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:P61106}. Note=Recruited to recycling endosomes by DENND6A. {ECO:0000250|UniProtKB:P61106}.
uniprot
proteins