POU2AF1
entrez
5450
canonical
uniprot
Q16633
canonical
ensembl
ENSG00000110777
resolver
ensp
ENSP00000376786
resolver
enst
ENST00000393067
resolver
genesymbol
POU2AF1
resolver
genesymbol_syn
BOB1
resolver
genesymbol_syn
OBF1
resolver
hgnc
HGNC:9211
resolver
uniprot
B2R8Z9
resolver
uniprot
Q14983
resolver
uniprot_entry
OBF1_HUMAN
resolver
uniprot_sec
B2R8Z9
resolver
uniprot_sec
Q14983
resolver
amino_acid_sequence
MLWQKPTAPEQAPAPARPYQGVRVKEPVKELLRRKRGHASSGAAPAPTAVVLPHQPLATYTTVGPSCLDMEGSVSAVTEEAALCAGWLSQPTPATLQPLAPWTPYTEYVPHEAVSCPYSADMYVQPVCPSYTVVGPSSVLTYASPPLITNVTTRSSATPAVGPPLEGPEHQAPLTYFPWPQPLSTLPTSTLQYQPPAPALPGPQFVQLPISIPEPVLQDMEDPRRAASSLTIDKLLLEEEDSDAYALNHTLSVEGF
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with BCL6. {ECO:0000269|PubMed:8574789}.
uniprot
proteins
function
FUNCTION: Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2 (PubMed:7859290). It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2 (PubMed:7779176). It recognizes the POU domains of POU2F1/OCT1 and POU2F2/OCT2 (PubMed:7779176). It is essential for the response of B-cells to antigens and required for the formation of germinal centers (PubMed:7623806, PubMed:7859290). Regulates IL6 expression in B cells as POU2F2/OCT2 coactivator (By similarity). {ECO:0000250|UniProtKB:Q64693, ECO:0000269|PubMed:7623806, ECO:0000269|PubMed:7779176, ECO:0000269|PubMed:7859290}.
uniprot
proteins
mass_dalton
27436
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation. {ECO:0000305|PubMed:11483517}.
uniprot
proteins
protein_family
POU2AF family
uniprot
proteins
pubmed
10541551
uniprot
proteins
pubmed
11483517
uniprot
proteins
pubmed
11483518
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
35576971
uniprot
proteins
pubmed
7623806
uniprot
proteins
pubmed
7779176
uniprot
proteins
pubmed
7859290
uniprot
proteins
pubmed
8574789
uniprot
proteins
sequence_length
256
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins