Dio2
entrez
13371
canonical
uniprot
Q9Z1Y9
canonical
ensembl
ENSMUSG00000007682
resolver
ensp
ENSMUSP00000081013
resolver
genesymbol
Dio2
resolver
uniprot
Q05A70
resolver
uniprot
Q9JHH1
resolver
uniprot
Q9QXV5
resolver
uniprot_entry
IOD2_MOUSE
resolver
uniprot_entry
Q9QXV5_MOUSE
resolver
uniprot_sec
Q05A70
resolver
uniprot_sec
Q9JHH1
resolver
amino_acid_sequence
MGLLSVDLLITLQILPVFFSNCLFLALYDSVILLKHVALLLSRSKSTRGEWRRMLTSEGLRCVWNSFLLDAYKQVKLGEDAPNSSVVHVSNPESGNNYASEKTADGAECHLLDFASAERPLVVNFGSATUPPFTRQLPAFRQLVEEFSSVADFLLVYIDEAHPSDGWAVPGDSSLSFEVKKHRNQEDRCAAAHQLLERFSLPPQCQVVADRMDNNANVAYGVAFERVCIVQRRKIAYLGGKGPFSYNLQEVRSWLEKNFSKRUILD
uniprot
proteins
ec_number
1.21.99.4
uniprot
proteins
function
FUNCTION: Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination (PubMed:10715551). Catalyzes the deiodination of L-thyroxine (T4) to 3,5,3'-triiodothyronine (T3) and 3,3',5'-triiodothyronine (rT3) to 3,3'-diiodothyronine (3,3'-T2) via outer-ring deiodination (ORD) (PubMed:10715551). Catalyzes the deiodination of 3',5'-diiodothyronine (3',5'-T2) to 3'-monoiodothyronine (3'-T1) via ORD (By similarity). Catalyzes the phenolic ring deiodinations of 3,3',5'-triiodothyronamine and 3',5'- diiodothyronamine (By similarity). {ECO:0000250|UniProtKB:Q92813, ECO:0000269|PubMed:10715551}.
uniprot
proteins
mass_dalton
29929
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by MARCHF6, leading to its degradation by the proteasome. Deubiquitinated by USP20 and USP33 (By similarity). {ECO:0000250|UniProtKB:Q92813}.
uniprot
proteins
protein_family
Iodothyronine deiodinase family
uniprot
proteins
pubmed
10655523
uniprot
proteins
pubmed
10715551
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9927339
uniprot
proteins
sequence_length
266
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q92813}; Single-pass type III membrane protein {ECO:0000250|UniProtKB:Q92813}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..34; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins