Tet3
entrez
194388
canonical
uniprot
Q8BG87
canonical
ensembl
ENSMUSG00000034832
resolver
ensp
ENSMUSP00000087049
resolver
ensp
ENSMUSP00000139630
resolver
enst
ENSMUST00000089622
resolver
genesymbol
Tet3
resolver
genesymbol_syn
Cxxc10
resolver
uniprot
A0A5K1VVP6
resolver
uniprot
K9JH93
resolver
uniprot
L0HN04
resolver
uniprot
Q4VAD3
resolver
uniprot
Q8C8N8
resolver
uniprot
Q8CI60
resolver
uniprot_entry
A0A5K1VVP6_MOUSE
resolver
uniprot_entry
TET3_MOUSE
resolver
uniprot_sec
K9JH93
resolver
uniprot_sec
L0HN04
resolver
uniprot_sec
Q4VAD3
resolver
uniprot_sec
Q8C8N8
resolver
uniprot_sec
Q8CI60
resolver
amino_acid_sequence
MSQFQVPLAVQPDLSGLYDFPQGQVMVGGFQGPGLPMAGSETQLRGGGDGRKKRKRCGTCDPCRRLENCGSCTSCTNRRTHQICKLRKCEVLKKKAGLLKEVEINAREGTGPWAQGATVKTGSELSPVDGPVPGQMDSGPVYHGDSRQLSTSGAPVNGAREPAGPGLLGAAGPWRVDQKPDWEAASGPTHAARLEDAHDLVAFSAVAEAVSSYGALSTRLYETFNREMSREAGSNGRGPRPESCSEGSEDLDTLQTALALARHGMKPPNCTCDGPECPDFLEWLEGKIKSMAMEGGQGRPRLPGALPPSEAGLPAPSTRPPLLSSEVPQVPPLEGLPLSQSALSIAKEKNISLQTAIAIEALTQLSSALPQPSHSTSQASCPLPEALSPSAPFRSPQSYLRAPSWPVVPPEEHPSFAPDSPAFPPATPRPEFSEAWGTDTPPATPRNSWPVPRPSPDPMAELEQLLGSASDYIQSVFKRPEALPTKPKVKVEAPSSSPAPVPSPISQREAPLLSSEPDTHQKAQTALQQHLHHKRNLFLEQAQDASFPTSTEPQAPGWWAPPGSPAPRPPDKPPKEKKKKPPTPAGGPVGAEKTTPGIKTSVRKPIQIKKSRSRDMQPLFLPVRQIVLEGLKPQASEGQAPLPAQLSVPPPASQGAASQSCATPLTPEPSLALFAPSPSGDSLLPPTQEMRSPSPMVALQSGSTGGPLPPADDKLEELIRQFEAEFGDSFGLPGPPSVPIQEPENQSTCLPAPESPFATRSPKKIKIESSGAVTVLSTTCFHSEEGGQEATPTKAENPLTPTLSGFLESPLKYLDTPTKSLLDTPAKKAQSEFPTCDCVEQIVEKDEGPYYTHLGSGPTVASIRELMEDRYGEKGKAIRIEKVIYTGKEGKSSRGCPIAKWVIRRHTLEEKLLCLVRHRAGHHCQNAVIVILILAWEGIPRSLGDTLYQELTDTLRKYGNPTSRRCGLNDDRTCACQGKDPNTCGASFSFGCSWSMYFNGCKYARSKTPRKFRLTGDNPKEEEVLRNSFQDLATEVAPLYKRLAPQAYQNQVTNEDVAIDCRLGLKEGRPFSGVTACMDFCAHAHKDQHNLYNGCTVVCTLTKEDNRCVGQIPEDEQLHVLPLYKMASTDEFGSEENQNAKVSSGAIQVLTAFPREVRRLPEPAKSCRQRQLEARKAAAEKKKLQKEKLSTPEKIKQEALELAGVTTDPGLSLKGGLSQQSLKPSLKVEPQNHFSSFKYSGNAVVESYSVLGSCRPSDPYSMSSVYSYHSRYAQPGLASVNGFHSKYTLPSFGYYGFPSSNPVFPSQFLGPSAWGHGGSGGSFEKKPDLHALHNSLNPAYGGAEFAELPGQAVATDNHHPIPHHQQPAYPGPKEYLLPKVPQLHPASRDPSPFAQSSSCYNRSIKQEPIDPLTQAESIPRDSAKMSRTPLPEASQNGGPSHLWGQYSGGPSMSPKRTNSVGGNWGVFPPGESPTIVPDKLNSFGASCLTPSHFPESQWGLFTGEGQQSAPHAGARLRGKPWSPCKFGNGTSALTGPSLTEKPWGMGTGDFNPALKGGPGFQDKLWNPVKVEEGRIPTPGANPLDKAWQAFGMPLSSNEKLFGALKSEEKLWDPFSLEEGTAEEPPSKGVVKEEKSGPTVEEDEEELWSDSEHNFLDENIGGVAVAPAHCSILIECARRELHATTPLKKPNRCHPTRISLVFYQHKNLNQPNHGLALWEAKMKQLAERARQRQEEAARLGLGQQEAKLYGKKRKWGGAMVAEPQHKEKKGAIPTRQALAMPTDSAVTVSSYAYTKVTGPYSRWI
uniprot
proteins
ec_number
1.14.11.80
uniprot
proteins
function
FUNCTION: Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming in the zygote following fertilization. Also mediates subsequent conversion of 5hmC into 5-formylcytosine (5fC), and conversion of 5fC to 5-carboxylcytosine (5caC). Conversion of 5mC into 5hmC, 5fC and 5caC probably constitutes the first step in cytosine demethylation. Selectively binds to the promoter region of target genes and contributes to regulate the expression of numerous developmental genes. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in DNA demethylation in the paternal pronucleus by mediating conversion of 5mC into 5hmC, 5fC and 5caC. Does not mediate DNA demethylation of maternal pronucleus because of the presence of DPPA3/PGC7 on maternal chromatin that prevents TET3-binding to chromatin. In addition to its role in DNA demethylation, also involved in the recruitment of the O-GlcNAc transferase OGT to CpG-rich transcription start sites of active genes, thereby promoting histone H2B GlcNAcylation by OGT. Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (By similarity). {ECO:0000250|UniProtKB:O43151, ECO:0000269|PubMed:20639862, ECO:0000269|PubMed:21407207, ECO:0000269|PubMed:21778364, ECO:0000269|PubMed:21892189, ECO:0000269|PubMed:22722204, ECO:0000269|PubMed:23690950, ECO:0000269|PubMed:26774490}.
uniprot
proteins
mass_dalton
194792
uniprot
proteins
mutagenesis
MUTAGEN 1002; /note="K->E: Strongly decreases ubiquitination, loss of DNA-binding and of 5-methylcytosine demethylase activity in vivo. Loss of nuclear localization, becomes mostly cytoplasmic."; /evidence="ECO:0000269|PubMed:25557551"; MUTAGEN 1002; /note="K->N: Strongly decreases ubiquitination, loss of DNA-binding and of 5-methylcytosine demethylase activity in vivo. Loss of nuclear localization, becomes mostly cytoplasmic."; /evidence="ECO:0000269|PubMed:25557551"; MUTAGEN 1085; /note="H->Y: Loss of enzyme activity; when associated with A-1087."; /evidence="ECO:0000269|PubMed:20639862, ECO:0000269|PubMed:21778364"; MUTAGEN 1087; /note="D->A: Loss of enzyme activity; when associated with Y-1085."; /evidence="ECO:0000269|PubMed:20639862, ECO:0000269|PubMed:21778364
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated at Lys-1002 by the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex called CRL4(VprBP) or CUL4A-RBX1-DDB1-DCAF1/VPRBP complex; this modification promotes binding to DNA. {ECO:0000269|PubMed:25557551}.
uniprot
proteins
protein_family
TET family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20639862
uniprot
proteins
pubmed
21321204
uniprot
proteins
pubmed
21407207
uniprot
proteins
pubmed
21778364
uniprot
proteins
pubmed
21892189
uniprot
proteins
pubmed
22722204
uniprot
proteins
pubmed
23151479
uniprot
proteins
pubmed
23217707
uniprot
proteins
pubmed
23690950
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24357321
uniprot
proteins
pubmed
25557551
uniprot
proteins
pubmed
26774490
uniprot
proteins
pubmed
28930672
uniprot
proteins
sequence_length
1803
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21892189, ECO:0000269|PubMed:25557551, ECO:0000269|PubMed:26774490, ECO:0000269|PubMed:28930672}. Chromosome {ECO:0000269|PubMed:26774490}. Cytoplasm {ECO:0000269|PubMed:21892189}. Note=At the zygotic stage, localizes in the male and female pronucleus, while it localizes to the cytoplasm at other preimplantation stages (PubMed:21892189, PubMed:28930672). Binds to the promoter of target genes, close to the transcription start site (PubMed:26774490). {ECO:0000269|PubMed:21892189, ECO:0000269|PubMed:26774490, ECO:0000269|PubMed:28930672}.
uniprot
proteins