Tsen54
entrez
76265
canonical
uniprot
Q8C2A2
canonical
ensembl
ENSMUSG00000020781
resolver
ensp
ENSMUSP00000021134
resolver
genesymbol
Tsen54
resolver
genesymbol_syn
Sen54
resolver
uniprot
B1ATA4
resolver
uniprot
B1ATA5
resolver
uniprot
Q9DCI5
resolver
uniprot_entry
SEN54_MOUSE
resolver
uniprot_sec
B1ATA4
resolver
uniprot_sec
B1ATA5
resolver
uniprot_sec
Q9DCI5
resolver
amino_acid_sequence
MEPEPEPGSVEVPAGRVLSASELRAARSRSQKLPQRSHGPKDFLPDGSEAQAERLRLCRQELWQLLAEERVERLGSLVAAEWKPEEGFVELTSPAGKFWQTMGYSEEGRQRLHPEEALYLLECGSIQLFYQDLPLSIQEAYQLLLTEDTLSFLQYQVFSHLKRLGYVVRRFQLSSVVSPYERQLNLDGYAQCLEDGSGKRKRSSSCRSVNKKPKVLQNSLPPVSLAASSSPACDQSSQYPEEKSQDSSPRQGSELPLQFLGSSEPCSDLAREDVGCDRESHKIENGAKGTPKLRWNFEQISFPNMASDSRHTFLPAPAPELLPANVIGRGTDAESWCQKLNQRREKLSRRDREQQAVVQQFREDVNADPEVRGCSSWQEYKELLQRRQTQKSQPRPPHLWGQSVTPLLDPDKADCPAAVLQHISVLQTTHLADGGYRLLEKSGGLQISFDVYQADAVATFRKNSPGKPYVRMCISGFDDPVPDLCSLKCLTYQSGDVPLIFALVDHGDISFYSFRDFTLPRDLGH
uniprot
proteins
function
FUNCTION: Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
59083
uniprot
proteins
protein_family
SEN54 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
525
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Nucleus, nucleolus {ECO:0000305}. Note=May be transiently localized in the nucleolus. {ECO:0000305}.
uniprot
proteins