Egflam
entrez
268780
canonical
uniprot
Q4VBE4
canonical
ensembl
ENSMUSG00000042961
resolver
ensp
ENSMUSP00000055599
resolver
ensp
ENSMUSP00000094238
resolver
genesymbol
Egflam
resolver
uniprot
B2RWU6
resolver
uniprot
B6JU28
resolver
uniprot
Q80WX4
resolver
uniprot
Q8BGP3
resolver
uniprot_entry
EGFLA_MOUSE
resolver
uniprot_sec
B2RWU6
resolver
uniprot_sec
B6JU28
resolver
uniprot_sec
Q80WX4
resolver
uniprot_sec
Q8BGP3
resolver
amino_acid_sequence
MDLISTFSLHFLLLACSLPPGAVSLRTALRKSGKVGPPLDIKLGALNCTAFSIQWKTPKRSGSSIIGYTVFYSEVGSDKSLRERSHNVPVGQDTLITEEVIGDLKPGTEYQVSVAAYSQTGKGRLSFPRHVTTLSQDSCLPPAAPQQPHVLVVSDSEVALSWRPGENEGSAPIQSYSVEFIRPDFDKSWTIIQERLQMDSMVIKGLDPDTNYQFAVKAMNAHGFSPRSWPSNTVRTLGPGEAGSGHYGPGYITNPGVSEDDDGSEDELDLDVSFEEVKPLPATKVGNKKFSVESKKTSVSNSVMGSRLAQPTSASLHETTVAIPPTPAQRKGKNSVAMMSRLFDMSCDETLCSADSFCVNDYAWGGSRCHCNLGKGGEACSEDIFIQYPQFFGHSYVTFEPLKNSYQAFQVTLEFRAEAEDGLLLYCGESEHGRGDFMSLALIRRSLHFRFNCGTGIAIIISETKIKLGAWHTVTLYRDGLNGMLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLSVNGKKIDMRPWPLGKALNGADVGECSSGICDEASCIHGGTCAAIKADSYICLCPLGFRGRHCEDAFALTIPQFRESLRSYAATPWPLEPQHYLSFTEFEITFRPDSGDGVLLYSYDTGSKDFLSINMAAGHVEFRFDCGSGTGVLRSEAPLTLGQWHDLRVSRTAKNGILQVDKQKVVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGILHPFSGSIQKIILNDRTIHVKHDFTSGVNVENAAHPCVGAPCAHGGSCRPRKEGYECDCPLGFEGLNCQKECGNHCLNTIIEAIEIPQFIGRSYLTYDNPNILKRVSGSRSNAFMRFKTTAKDGLLLWRGDSPMRPNSDFISLGLRDGALIFSYNLGSGVASIMVNGSFSDGRWHRVKAVRDGQSGKITVDDYGARTGKSPGLMRQLNINGALYVGGMKEIALHTNRQYLRGLVGCISHFTLSTDYHISLVEDAVDGKNINTCGAK
uniprot
proteins
function
FUNCTION: Involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception (PubMed:18641643, PubMed:18757743, PubMed:30282023). Plays a key role in the synaptic organization of photoreceptors by mediating transsynaptic interaction between alpha-dystroglycan and GPR179 on the postsynaptic membrane (PubMed:30282023). Necessary for proper bipolar dendritic tip apposition to the photoreceptor ribbon synapse (PubMed:18641643, PubMed:18757743, PubMed:30282023). Promotes matrix assembly and cell adhesiveness (PubMed:18641643, PubMed:18757743). {ECO:0000269|PubMed:18641643, ECO:0000269|PubMed:18757743, ECO:0000269|PubMed:30282023}.
uniprot
proteins
mass_dalton
110735
uniprot
proteins
post_translational_modification
PTM: O-glycosylated; contains chondroitin sulfate and heparan sulfate. {ECO:0000269|PubMed:18757743}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18641643
uniprot
proteins
pubmed
18757743
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30282023
uniprot
proteins
sequence_length
1017
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:18757743}. Synaptic cleft {ECO:0000269|PubMed:18641643, ECO:0000269|PubMed:30282023}. Presynaptic active zone {ECO:0000269|PubMed:18641643}. Note=Detected in the synaptic cleft of the ribbon synapse around the postsynaptic terminals of bipolar cells (PubMed:18641643). Colocalizes with BSN, CTBP2 and DAG1 in photoreceptor synaptic terminals (PubMed:18641643). {ECO:0000269|PubMed:18641643}.
uniprot
proteins