St6galnac3
entrez
20447
canonical
uniprot
Q9WUV2
canonical
ensembl
ENSMUSG00000052544
resolver
ensp
ENSMUSP00000143747
resolver
enst
ENSMUST00000200397
resolver
genesymbol
St6galnac3
resolver
genesymbol_syn
Siat7c
resolver
uniprot
Q544M3
resolver
uniprot
Q9JHP5
resolver
uniprot_entry
Q544M3_MOUSE
resolver
uniprot_entry
SIA7C_MOUSE
resolver
uniprot_sec
Q9JHP5
resolver
amino_acid_sequence
MACILKRKPVLVVSFIALCILLLAMRLVNDATFPLLLNCFGQPKTKWIPLPYTFRQPLRTHYGYINVRTQEPLQLNCNHCAIVSNSGQMVGQKVGEEIDHASCIWRMNNAPTKGFEEDVGYMTMVRVVSHTSVPLLLKNPDYFFKEASRTIYVIWGPFRNMRKDGNGIVYNMLKKTVDAYPDAQIYVTTEQQMTHCDRVFKDETGKDRVQSGSYLSTGWFTFILAMDACYSIHVYGMINETYCKTEGYRKVPYHYYEQGKDECNEYLLHEHAPYGGHRFITEKKVFAKWAKKHRIVFTHPNWTLS
uniprot
proteins
ec_number
2.4.3.7
uniprot
proteins
function
FUNCTION: Transfers the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of glycoproteins and glycolipids forming an alpha-2,6-linkage. Produces branched type disialyl structures by transfer of a sialyl group onto a GalNAc residue inside the backbone core chains. ST6GalNAcIII prefers glycolipids to glycoproteins, predominantly catalyzing the biosynthesis of ganglioside GD1alpha from GM1b (PubMed:10207017, PubMed:10601645). GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity). Sialylation of glycoproteins or glycosphingolipids is very important in tumor development, neuronal development, nerve repair, immunological processes and regulation of hormone sensitivity (By similarity). {ECO:0000250|UniProtKB:Q8NDV1, ECO:0000250|UniProtKB:Q9QYJ1, ECO:0000269|PubMed:10207017, ECO:0000269|PubMed:10601645}.
uniprot
proteins
mass_dalton
35414
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000305|PubMed:10207017, ECO:0000305|PubMed:10601645}.; PATHWAY: Glycolipid biosynthesis. {ECO:0000305|PubMed:10207017, ECO:0000305|PubMed:10601645}.
uniprot
proteins
protein_family
Glycosyltransferase 29 family
uniprot
proteins
pubmed
10207017
uniprot
proteins
pubmed
10601645
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
305
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..28; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins