CAVIN4
entrez
347273
canonical
uniprot
Q5BKX8
canonical
ensembl
ENSG00000170681
resolver
ensp
ENSP00000418668
resolver
enst
ENST00000307584
resolver
genesymbol
CAVIN4
resolver
genesymbol_syn
MURC
resolver
hgnc
HGNC:33742
resolver
uniprot
B1PRL3
resolver
uniprot
B4DT88
resolver
uniprot_entry
CAVN4_HUMAN
resolver
uniprot_sec
B1PRL3
resolver
uniprot_sec
B4DT88
resolver
amino_acid_sequence
MEHNGSASNADKIHQNRLSSVTEDEDQDAALTIVTVLDKVASIVDSVQASQKRIEERHREMENAIKSVQIDLLKLSQSHSNTGHIINKLFEKTRKVSAHIKDVKARVEKQQIHVKKVEVKQEEIMKKNKFRVVIFQEKFRCPTSLSVVKDRNLTENQEEDDDDIFDPPVDLSSDEEYYVEESRSARLRKSGKEHIDNIKKAFSKENMQKTRQNLDKKVNRIRTRIVTPERRERLRQSGERLRQSGERLRQSGERFKKSISNAAPSKEAFKMRSLRKGKDRTVAEGEECAREMGVDIIARSESLGPISELYSDELSEPEHEAARPVYPPHEGREIPTPEPLKVTFKSQVKVEDDESLLLDLKHSS
uniprot
proteins
function
FUNCTION: Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation. Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes (By similarity). Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway (PubMed:18332105). {ECO:0000250|UniProtKB:A2AMM0, ECO:0000269|PubMed:18332105}.
uniprot
proteins
mass_dalton
41899
uniprot
proteins
protein_family
CAVIN family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18332105
uniprot
proteins
pubmed
19525939
uniprot
proteins
pubmed
24567387
uniprot
proteins
pubmed
26497963
uniprot
proteins
pubmed
26614875
uniprot
proteins
sequence_length
364
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:A2AMM0}. Cytoplasm {ECO:0000250|UniProtKB:A2AMM0}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:A2AMM0}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:A2AMM0}. Membrane, caveola {ECO:0000269|PubMed:19525939}. Cell membrane {ECO:0000269|PubMed:26497963}. Note=In cardiomyocytes, accumulates in the Z-line of the sarcomere. In vascular smooth muscle cells, detected diffusely throughout the cytoplasm. Localizes in the caveolae in a caveolin-dependent manner. {ECO:0000250|UniProtKB:A2AMM0}.
uniprot
proteins