Kank1
entrez
107351
canonical
uniprot
E9Q238
canonical
ensembl
ENSMUSG00000032702
resolver
ensp
ENSMUSP00000042177
resolver
ensp
ENSMUSP00000116660
resolver
ensp
ENSMUSP00000212456
resolver
ensp
ENSMUSP00000212457
resolver
ensp
ENSMUSP00000212459
resolver
ensp
ENSMUSP00000212461
resolver
ensp
ENSMUSP00000212464
resolver
ensp
ENSMUSP00000212467
resolver
ensp
ENSMUSP00000212468
resolver
ensp
ENSMUSP00000212469
resolver
ensp
ENSMUSP00000212470
resolver
ensp
ENSMUSP00000212472
resolver
enst
ENSMUST00000049400
resolver
genesymbol
Kank1
resolver
genesymbol_syn
Ankrd15
resolver
uniprot
Q6AXG6
resolver
uniprot
Q8BRZ8
resolver
uniprot_entry
KANK1_MOUSE
resolver
uniprot_entry
Q6AXG6_MOUSE
resolver
uniprot_entry
Q8BRZ8_MOUSE
resolver
amino_acid_sequence
MAYTTKVNGCAAEKADGVLNGDHNKEKKDPYFVETPYGFQLDLDFVKYVDDIQKGNTIKKLNIQKRRKPSVPCPEVRAIPGHQGVWTSTESLSSSNSDDSKQCPSFLLARSHVTSTPIPRPPAPLETSPTFAVSENRQLLPPPSPQLPRHNLHVTKTLMETRRRLEQERVTMQMAPGDFRRPRLASFGGMGSTSSLPSFVGSANHSSAIHQLQNGYQGNGDYNSYVPAAPTTSSMGSSVRHSPLSSGISTPVTNVSPMHLQHIREQMAIALKRLKELEEQVRTIPVLQVKISVLQEEKRQLASQLKSQRASSQNEACGVRKRSYSAGNASQLELLARARRGGGELYIDYEEEEMESVEQSTQRIQEFRQLTADMQALERKIQDSSCEVASELRENGQCPSRECKSVAVGSDENMNDVVVYHRDLRPCKDTAVGTVTETRNVGISVTEAMLGVITEADKEIELQQQTIEALKEKIYRLEVQLKETTHDREMTKLKQELQAAGSRKKVDKATMAQPLVFSKLVEALVPTRDQMVGSHVDTRESCVGTSVQTSSVGTSCHPDCKNQVVGSELPMNWWVVKERVAMHDQCVGRSVETCDRSVGVEVSVCETGSNTEASGSDLTLLKTNLNLKDVRSIGCGDCSVDVIVCFPKECTSRSMNTEAVGQEEAAVMAVPHTTDQHTSTNLERVDQCTNTEAATLVESCTNTLLSTMDKQTSTQTVEMRTVAIGEGRVRDINPSTKTRSVGVGTVLSGNSEFDRPCAVKTKESGVGQINIQDNYLVGLKMRTIACGPPQLTVGLMGSRRSVGVGNEPVGELPEESPQPRVASGMVTGLDHYIERVQRLLAEQQTLLAENYSELAEAFGEPHSQIGSLNSQLISTLSSINSVMKSASTEELRNSDFQKASLGKTTGNHLEYTCKCGGLRSGGLLNVQPSQPEVEAETAEGKHSRGHEQFPMQGSTLPPVNLTDDQIATGLYVCPNNENTLKSIMKKSDGNKDSNGAKKNLQFIGINGGYETTSSDESSSDGSSSSESDDECDTIGYPPEEEEEEEEKDHDTRGMAEGHHAVNIEGFKSARVEDEVQVPECEPEKEEIRERYELSEKMLSACNLLKYNIKDPKALASKDMRICLNTLQHDWFRVSSQKSAVPAMVGDYIAAFEAVSPDVLRYIINMADGNGNTALHYSVSHSNFQIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMQVVEELFSCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHLNFSKAQSPSTPRLGRKTSPGPTHRGSFD
uniprot
proteins
function
FUNCTION: Adapter protein that links structural and signaling protein complexes positioned to guide microtubule and actin cytoskeleton dynamics during cell morphogenesis (By similarity). At focal adhesions (FAs) rims, organizes cortical microtubule stabilizing complexes (CMSCs) and directly interacts with major FA component TLN1, forming macromolecular assemblies positioned to control microtubule-actin crosstalk at the cell edge (By similarity). Recruits KIF21A in CMSCs at axonal growth cones and regulates axon guidance by suppressing microtubule growth without inducing microtubule disassembly once it reaches the cell cortex (By similarity). Interacts with ARFGEF1 and participates in establishing microtubule-organizing center (MTOC) orientation and directed cell movement in wound healing (By similarity). Regulates actin stress fiber formation and cell migration by inhibiting RHOA activation in response to growth factors; this function involves phosphorylation through PI3K/Akt signaling and may depend on the competitive interaction with 14-3-3 adapter proteins to sequester them from active complexes (By similarity). Inhibits the formation of lamellipodia but not of filopodia; this function may depend on the competitive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; this function is partially mediated by BAIAP2 (By similarity). In the nucleus, is involved in beta-catenin-dependent activation of transcription (By similarity). During cell division, may regulate DAAM1-dependent RHOA activation that signals centrosome maturation and chromosomal segregation. May also be involved in contractile ring formation during cytokinesis (PubMed:28284839). Potential tumor suppressor for renal cell carcinoma (By similarity). {ECO:0000250|UniProtKB:Q14678, ECO:0000269|PubMed:28284839}.
uniprot
proteins
mass_dalton
148254
uniprot
proteins
mutagenesis
MUTAGEN 1176; /note="Y->C: Impairs KIF21A binding."; /evidence="ECO:0000269|PubMed:29217769"; MUTAGEN 1179; /note="S->F: Does not affect KIF21A binding."; /evidence="ECO:0000269|PubMed:29217769"; MUTAGEN 1201; /note="N->D: Impairs KIF21A binding."; /evidence="ECO:0000269|PubMed:29217769"; MUTAGEN 1248; /note="L->Q: Impairs KIF21A binding."; /evidence="ECO:0000269|PubMed:29217769"; MUTAGEN 1276; /note="S->F: Impairs KIF21A binding."; /evidence="ECO:0000269|PubMed:29217769"; MUTAGEN 1284; /note="E->K: Impairs KIF21A binding."; /evidence="ECO:0000269|PubMed:29217769"; MUTAGEN 1306; /note="D->K: Impairs KIF21A binding."; /evidence="ECO:0000269|PubMed:29217769
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
28284839
uniprot
proteins
pubmed
29217769
uniprot
proteins
sequence_length
1360
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cell cortex {ECO:0000269|PubMed:29217769}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q14678}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14678}. Cytoplasm {ECO:0000269|PubMed:29217769}. Nucleus {ECO:0000250|UniProtKB:Q14678}. Note=Shuttles between the cytoplasm and nucleus. Colocalizes with CMSC components at focal adhesion rims. Colocalizes with KIF21A in membrane ruffles (By similarity). Colocalizes with RHOA at the contractile ring. Colocalizes with RHOA and DAAM1 around centrosomes (PubMed:28284839). {ECO:0000250|UniProtKB:Q14678, ECO:0000269|PubMed:28284839}.
uniprot
proteins