NDRG1
entrez
10397
canonical
uniprot
Q92597
canonical
ensembl
ENSG00000104419
resolver
ensp
ENSP00000319977
resolver
ensp
ENSP00000404854
resolver
ensp
ENSP00000427894
resolver
ensp
ENSP00000437443
resolver
genesymbol
NDRG1
resolver
genesymbol_syn
CAP43
resolver
genesymbol_syn
DRG1
resolver
genesymbol_syn
RTP
resolver
hgnc
HGNC:7679
resolver
uniprot
B3KR80
resolver
uniprot
B7Z446
resolver
uniprot
O15207
resolver
uniprot
Q6IBG2
resolver
uniprot
Q8N959
resolver
uniprot
Q9NYR6
resolver
uniprot
Q9UK29
resolver
uniprot_entry
NDRG1_HUMAN
resolver
uniprot_entry
Q8N959_HUMAN
resolver
uniprot_sec
B3KR80
resolver
uniprot_sec
B7Z446
resolver
uniprot_sec
O15207
resolver
uniprot_sec
Q6IBG2
resolver
uniprot_sec
Q9NYR6
resolver
uniprot_sec
Q9UK29
resolver
amino_acid_sequence
MSREMQDVDLAEVKPLVEKGETITGLLQEFDVQEQDIETLHGSVHVTLCGTPKGNRPVILTYHDIGMNHKTCYNPLFNYEDMQEITQHFAVCHVDAPGQQDGAASFPAGYMYPSMDQLAEMLPGVLQQFGLKSIIGMGTGAGAYILTRFALNNPEMVEGLVLINVNPCAEGWMDWAASKISGWTQALPDMVVSHLFGKEEMQSNVEVVHTYRQHIVNDMNPGNLHLFINAYNSRRDLEIERPMPGTHTVTLQCPALLVVGDSSPAVDAVVECNSKLDPTKTTLLKMADCGGLPQISQPAKLAEAFKYFVQGMGYMPSASMTRLMRSRTASGSSVTSLDGTRSRSHTSEGTRSRSHTSEGTRSRSHTSEGAHLDITPNSGAAGNSAGPKSMEVSC
uniprot
proteins
disease_involvement
DISEASE: Charcot-Marie-Tooth disease, demyelinating, type 4D (CMT4D) [MIM:601455]: A recessive demyelinating form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Demyelinating neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. By convention autosomal recessive forms of demyelinating Charcot-Marie-Tooth disease are designated CMT4. {ECO:0000269|PubMed:10831399}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy. {ECO:0000269|PubMed:15247272, ECO:0000269|PubMed:15377670, ECO:0000269|PubMed:17786215, ECO:0000269|PubMed:9766676}.
uniprot
proteins
mass_dalton
42835
uniprot
proteins
post_translational_modification
PTM: Under stress conditions, phosphorylated in the C-terminal on many serine and threonine residues. Phosphorylated in vitro by PKA. Phosphorylation enhanced by increased intracellular cAMP levels. Homocysteine induces dephosphorylation. Phosphorylation by SGK1 is cell cycle dependent. {ECO:0000269|PubMed:10860807, ECO:0000269|PubMed:15461589, ECO:0000269|PubMed:18787837, ECO:0000269|PubMed:21708134}.
uniprot
proteins
protein_family
NDRG family
uniprot
proteins
pubmed
10395947
uniprot
proteins
pubmed
10831399
uniprot
proteins
pubmed
10860807
uniprot
proteins
pubmed
12432451
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15247272
uniprot
proteins
pubmed
15377670
uniprot
proteins
pubmed
15461589
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15922294
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17316623
uniprot
proteins
pubmed
17487921
uniprot
proteins
pubmed
17786215
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18787837
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21708134
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8939898
uniprot
proteins
pubmed
9251681
uniprot
proteins
pubmed
9605764
uniprot
proteins
pubmed
9766676
uniprot
proteins
sequence_length
394
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cell membrane. Note=Mainly cytoplasmic but differentially localized to other regions. Associates with the plasma membrane in intestinal epithelia and lactating mammary gland. Translocated to the nucleus in a p53/TP53-dependent manner. In prostate epithelium and placental chorion, located in both the cytoplasm and in the nucleus. No nuclear localization in colon epithelium cells. In intestinal mucosa, prostate and renal cortex, located predominantly adjacent to adherens junctions. Cytoplasmic with granular staining in proximal tubular cells of the kidney and salivary gland ducts. Recruits to the membrane of recycling/sorting and late endosomes via binding to phosphatidylinositol 4-phosphate. Associates with microtubules. Colocalizes with TUBG1 in the centrosome. Cytoplasmic location increased with hypoxia. Phosphorylated form found associated with centromeres during S-phase of mitosis and with the plasma membrane.
uniprot
proteins