HAND2
entrez
9464
canonical
uniprot
P61296
canonical
ensembl
ENSG00000164107
resolver
ensp
ENSP00000352565
resolver
genesymbol
HAND2
resolver
genesymbol_syn
BHLHA26
resolver
genesymbol_syn
DHAND
resolver
hgnc
HGNC:4808
resolver
uniprot
B6ECG9
resolver
uniprot
O95300
resolver
uniprot
O95301
resolver
uniprot
P97833
resolver
uniprot
Q494T1
resolver
uniprot_entry
HAND2_HUMAN
resolver
uniprot_sec
B6ECG9
resolver
uniprot_sec
O95300
resolver
uniprot_sec
O95301
resolver
uniprot_sec
P97833
resolver
uniprot_sec
Q494T1
resolver
amino_acid_sequence
MSLVGGFPHHPVVHHEGYPFAAAAAAAAAAAASRCSHEENPYFHGWLIGHPEMSPPDYSMALSYSPEYASGAAGLDHSHYGGVPPGAGPPGLGGPRPVKRRGTANRKERRRTQSINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDLLAKDDQNGEAEAFKAEIKKTDVKEEKRKKELNEILKSTVSSNDKKTKGRTGWPQHVWALELKQ
uniprot
proteins
function
FUNCTION: Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Also plays an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
23666
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19348682
uniprot
proteins
pubmed
9878849
uniprot
proteins
sequence_length
217
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
uniprot
proteins