Gid8
entrez
76425
canonical
uniprot
Q9D7M1
canonical
ensembl
ENSMUSG00000027573
resolver
ensp
ENSMUSP00000029090
resolver
ensp
ENSMUSP00000077753
resolver
ensp
ENSMUSP00000213300
resolver
ensp
ENSMUSP00000213301
resolver
ensp
ENSMUSP00000213307
resolver
ensp
ENSMUSP00000213309
resolver
enst
ENSMUST00000029090
resolver
enst
ENSMUST00000078687
resolver
genesymbol
Gid8
resolver
uniprot_entry
GID8_MOUSE
resolver
amino_acid_sequence
MSYAEKPDEITKDEWMEKLNNLHVQRADMNRLIMNYLVTEGFKEAAEKFRMESGIEPSVDLETLDERIKIREMILKGQIQEAIALINSLHPELLDTNRYLYFHLQQQHLIELIRQRETEAALEFAQTQLAEQGEESRECLTEMERTLALLAFDSPEESPFGDLLHMMQRQKVWSEVNQAVLDYENRESTPKLAKLLKLLLWAQNELDQKKVKYPKMTDLSKGVIEEPK
uniprot
proteins
function
FUNCTION: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Acts as a positive regulator of Wnt signaling pathway by promoting beta-catenin (CTNNB1) nuclear accumulation. {ECO:0000250|UniProtKB:Q9NWU2}.
uniprot
proteins
mass_dalton
26779
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated through 'Lys-48'-polyubiquitin chains, leading to proteasomal degradation in the absence of Wnt stimulation. {ECO:0000250|UniProtKB:Q9NWU2}.
uniprot
proteins
protein_family
GID8 family
uniprot
proteins
pubmed
12559565
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27920276
uniprot
proteins
sequence_length
228
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9NWU2}. Nucleus {ECO:0000250|UniProtKB:Q9NWU2}. Note=Localizes in the cytoplasm in the absence of Wnt stimulation and in the nucleus in the presence of Wnt stimulation. {ECO:0000250|UniProtKB:Q9NWU2}.
uniprot
proteins