Mme
entrez
24590
canonical
uniprot
P07861
canonical
ensembl
ENSRNOG00000009514
resolver
ensembl
ENSRNOG00055018375
resolver
ensembl
ENSRNOG00065026657
resolver
ensp
ENSRNOP00000044578
resolver
ensp
ENSRNOP00055025158
resolver
ensp
ENSRNOP00065037763
resolver
enst
ENSRNOT00000042576
resolver
enst
ENSRNOT00055031196
resolver
enst
ENSRNOT00065046025
resolver
genesymbol
Mme
resolver
uniprot_entry
NEP_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited in a dose dependent manner by sialorphin. {ECO:0000269|PubMed:12835417}.
uniprot
proteins
amino_acid_sequence
MGRSESQMDITDINAPKPKKKQRWTPLEISLSVLVLLLTIIAVTMIALYATYDDGICKSSDCIKSAARLIQNMDASAEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDELEVILKDVLQEPKTEDIVAVQKAKTLYRSCINESAIDSRGGQPLLTLLPDIYGWPVASQNWEQTYGTSWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTGIYKEACTAYVDFMISVARLIRQEQRLPIDENQLSLEMNKVMELEKEIANATTKPEDRNDPMLLYNKMTLAKLQNNFSLEINGKPFSWSNFTNEIMSTVNINIQNEEEVVVYAPEYLTKLKPILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKALYGTTSETATWRRCANYVNGNMENAVGRLYVEAAFAGESKHVVEDLIAQIREVFIQTLDDLTWMDAETKKKAEEKALAIKERIGYPDDIISNENKLNNEYLELNYKEEEYFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSARQSNSLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSANNFKDQSQCMVYQYGNFTWDLAGGQHLNGINTLGENIADNGGIGQAYRAYQNYVKKNGEEKLLPGLDLNHKQLFFLNFAQVWCGTYRPEYAVNSIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPERKCRVW
uniprot
proteins
ec_number
3.4.24.11
uniprot
proteins
function
FUNCTION: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:2966343). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:2966343). Catalyzes cleavage of bradykinin, substance P and neurotensin peptides (By similarity). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:2966343). Involved in the degradation of the atrial natriuretic factor (ANF) (PubMed:2966343). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (By similarity). {ECO:0000250|UniProtKB:P08473, ECO:0000269|PubMed:2966343}.
uniprot
proteins
mass_dalton
85795
uniprot
proteins
post_translational_modification
PTM: Myristoylation is a determinant of membrane targeting. {ECO:0000250|UniProtKB:P08473}.; PTM: Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity. {ECO:0000250|UniProtKB:P08473}.
uniprot
proteins
protein_family
Peptidase M13 family
uniprot
proteins
pubmed
12835417
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2703483
uniprot
proteins
pubmed
2966343
uniprot
proteins
pubmed
3555489
uniprot
proteins
sequence_length
750
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P08473}; Single-pass type II membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 29..51; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins