SHLD1
entrez
149840
canonical
uniprot
Q8IYI0
canonical
ensembl
ENSG00000171984
resolver
ensp
ENSP00000305875
resolver
ensp
ENSP00000368263
resolver
ensp
ENSP00000797137
resolver
enst
ENST00000378979
resolver
genesymbol
SHLD1
resolver
genesymbol_syn
C20orf196
resolver
genesymbol_syn
RINN3
resolver
hgnc
HGNC:26318
resolver
uniprot
A8K9J3
resolver
uniprot
Q5TGA6
resolver
uniprot
Q5TGA9
resolver
uniprot
Q96LU1
resolver
uniprot_entry
Q5TGA6_HUMAN
resolver
uniprot_entry
SHLD1_HUMAN
resolver
uniprot_sec
A8K9J3
resolver
uniprot_sec
Q5TGA9
resolver
uniprot_sec
Q96LU1
resolver
amino_acid_sequence
MAARDATSGSLSEESSALDLPSACDIRDYVLQGPSQEANSEAFSSLEFHSFPYSSDVDPDTSNLNIEQNNSWTAENFWLDPAVKGQSEKEEDDGLRKSLDRFYEMFGHPQPGSANSLSASVCKCLSQKITQLRGQESQKYALRSFQMARVIFNRDGCSVLQRHSRDTHFYPLEEGSTSLDDEKPNPGLSKDITHFLLQQNVMKDL
uniprot
proteins
function
FUNCTION: Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres. {ECO:0000269|PubMed:29656893}.
uniprot
proteins
mass_dalton
22938
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
29656893
uniprot
proteins
pubmed
34354233
uniprot
proteins
sequence_length
205
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:29656893}.
uniprot
proteins