Acta1
entrez
11459
canonical
uniprot
P68134
canonical
ensembl
ENSMUSG00000031972
resolver
ensp
ENSMUSP00000034453
resolver
ensp
ENSMUSP00000321415
resolver
enst
ENSMUST00000034453
resolver
genesymbol
Acta1
resolver
genesymbol_syn
Acta
resolver
uniprot
P02568
resolver
uniprot
P99020
resolver
uniprot_entry
ACTS_MOUSE
resolver
uniprot_sec
P02568
resolver
uniprot_sec
P99020
resolver
amino_acid_sequence
MCDEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
uniprot
proteins
mass_dalton
42051
uniprot
proteins
post_translational_modification
PTM: Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization. {ECO:0000269|PubMed:23911929}.; PTM: Monomethylation at Lys-86 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. {ECO:0000250|UniProtKB:P68133}.; PTM: Methylated at His-75 by SETD3. {ECO:0000250|UniProtKB:P68133}.; PTM: [Actin, alpha skeletal muscle, intermediate form]: N-terminal cleavage of acetylated cysteine of intermediate muscle actin by ACTMAP. {ECO:0000269|PubMed:36173861}.
uniprot
proteins
protein_family
Actin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23911929
uniprot
proteins
pubmed
3013550
uniprot
proteins
pubmed
3023820
uniprot
proteins
pubmed
36173861
uniprot
proteins
sequence_length
377
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
uniprot
proteins