Q8VBZ0
uniprot
Q8VBZ0
canonical
amino_acid_sequence
MSTLRALRAVLCVYAVGIAVALAQLLRRLRGDFRPPVLPPQPGRVAIVTGATAGIGRSTARQLARLGMCVVVAGNDEHRGQEVVSSIRAEMGSDRAHFLPLDLASLASVRGFARDFQALGLPLHLLVNNAGVMLEPRAETEDGFERHLGVNFLGHFLLTLLLLPALRASGAEGRGSRVVTVGSATHYVGTVDMADLHGRHAYSPYAAYAQSKLALALFALQLQRILDARGDPVTSNMADPGVVDTELYRHAGWVLRTAKRFLGWLVFKSPEEGAWTLVYAAAAPELEGVGGRYLRDEAEAEPLGTARDQELQRRLWAEGLRLTGAGGGDSDGVAW
uniprot
proteins
ec_number
1.1.1.441
uniprot
proteins
function
FUNCTION: Oxidoreductase that plays a key role in early steps of protein N-linked glycosylation by mediating two non-consecutive steps in dolichol biosynthesis. Acts both as a NAD(+)-dependent dehydrogenase and as a NADPH-dependent reductase during the conversion of polyprenol into dolichol. First catalyzes the NAD(+)-dependent dehydrogenation of polyprenol into polyprenal; polyprenal is then reduced into dolichal by SRD5A3. It then catalyzes the NADPH-dependent reduction of dolichal into dolichol. May also acts as a positive regulator of starvation-induced autophagy. {ECO:0000250|UniProtKB:Q8N5I4}.
uniprot
proteins
mass_dalton
35957
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:Q8N5I4}.
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
11731500
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
335
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lipid droplet {ECO:0000250|UniProtKB:Q8N5I4}. Secreted {ECO:0000250|UniProtKB:Q8N5I4}. Note=Secreted in a non-classical form; a signal peptide sequence at position 1-31 is predicted. {ECO:0000250|UniProtKB:Q8N5I4}.
uniprot
proteins