CENPN
entrez
55839
canonical
uniprot
Q96H22
canonical
ensembl
ENSG00000166451
resolver
ensembl
ENSG00000291964
resolver
ensp
ENSP00000299572
resolver
ensp
ENSP00000305608
resolver
ensp
ENSP00000377007
resolver
ensp
ENSP00000393991
resolver
ensp
ENSP00000395235
resolver
ensp
ENSP00000454327
resolver
genesymbol
CENPN
resolver
genesymbol_syn
C16orf60
resolver
genesymbol_syn
ICEN32
resolver
hgnc
HGNC:30873
resolver
uniprot
A8MZE6
resolver
uniprot
B3KN53
resolver
uniprot
B4DJD1
resolver
uniprot
B4DPY7
resolver
uniprot
C9JJM5
resolver
uniprot
D3DUK8
resolver
uniprot
E7ES30
resolver
uniprot
E7ETS3
resolver
uniprot
Q9NZ83
resolver
uniprot_entry
CENPN_HUMAN
resolver
uniprot_sec
A8MZE6
resolver
uniprot_sec
B3KN53
resolver
uniprot_sec
B4DJD1
resolver
uniprot_sec
B4DPY7
resolver
uniprot_sec
C9JJM5
resolver
uniprot_sec
D3DUK8
resolver
uniprot_sec
E7ES30
resolver
uniprot_sec
E7ETS3
resolver
uniprot_sec
Q9NZ83
resolver
amino_acid_sequence
MDETVAEFIKRTILKIPMNELTTILKAWDFLSENQLQTVNFRQRKESVVQHLIHLCEEKRASISDAALLDIIYMQFHQHQKVWEVFQMSKGPGEDVDLFDMKQFKNSFKKILQRALKNVTVSFRETEENAVWIRIAWGTQYTKPNQYKPTYVVYYSQTPYAFTSSSMLRRNTPLLGQALTIASKHHQIVKMDLRSRYLDSLKAIVFKQYNQTFETHNSTTPLQERSLGLDINMDSRIIHENIVEKERVQRITQETFGDYPQPQLEFAQYKLETKFKSGLNGSILAEREEPLRCLIKFSSPHLLEALKSLAPAGIADAPLSPLLTCIPNKRMNYFKIRDK
uniprot
proteins
function
FUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. {ECO:0000269|PubMed:16622419, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:18007590, ECO:0000269|PubMed:19543270}.
uniprot
proteins
mass_dalton
39555
uniprot
proteins
mutagenesis
MUTAGEN 11; /note="R->A: Decreases the binding to centromeres."; /evidence="ECO:0000269|PubMed:19543270"; MUTAGEN 196; /note="R->A: Decreases the binding to centromeres."; /evidence="ECO:0000269|PubMed:19543270
uniprot
proteins
protein_family
CENP-N/CHL4 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
16622419
uniprot
proteins
pubmed
16622420
uniprot
proteins
pubmed
16716197
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18007590
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19543270
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
27499292
uniprot
proteins
sequence_length
339
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres. Kinetochore-bound levels decrease when cells enter mitosis and increase again when cells exit mitosis.
uniprot
proteins