Nudt18
entrez
361068
canonical
uniprot
Q641Y7
canonical
ensembl
ENSRNOG00000011831
resolver
ensembl
ENSRNOG00055015408
resolver
ensembl
ENSRNOG00065018562
resolver
ensp
ENSRNOP00000015969
resolver
ensp
ENSRNOP00055021375
resolver
ensp
ENSRNOP00065024821
resolver
enst
ENSRNOT00000015969
resolver
enst
ENSRNOT00055026295
resolver
enst
ENSRNOT00065031169
resolver
genesymbol
Nudt18
resolver
uniprot
B0BNL9
resolver
uniprot
Q4KM80
resolver
uniprot_entry
B0BNL9_RAT
resolver
uniprot_entry
NUD18_RAT
resolver
uniprot_sec
Q4KM80
resolver
amino_acid_sequence
MATEGLAGALATVLGGKGLLVQSCDSEPAGKPLLPVRLRKNVCYVVLAVFLNEQDEVLMIQEAKRECRGTWYLPAGRMEPGETIVEAMQREVKEEAGLLCEPVTLLSVEERGASWIRFVFLARPTGGVLKTSKNADSESLQAGWYPRVSLPTPLRAHDVVHLVELGAKFCQQATHPLILPQELPCNMVCQRLVATFTTVQSVWVLVGTVGTPHLPITACGFTPMEQRGGIKVAILRLLQECLTLHSLAVETKGLLGLQHLGRDHVDGICLNVLVTVAFRNPGIQDEPPKIRGENYFWWKVLEEDLQKQLLHRLQESSVVPLTR
uniprot
proteins
ec_number
3.6.1.58
uniprot
proteins
ec_number
3.6.1.68
uniprot
proteins
ec_number
3.6.1.76
uniprot
proteins
function
FUNCTION: Mediates the hydrolysis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Also hydrolyzes 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolysis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools. In vitro, it catalyzes the hydrolysis of isoprene pyrophosphates, including (2E)-geranyl diphosphate, isopentenyl diphosphate, (2E,6E)-farnesyl diphosphate and dimethylallyl diphosphate. It may therefore play a role in the control of cellular levels of these metabolites that are essential for multiple cellular processes, including isoprenoids synthesis and protein isoprenylation. {ECO:0000250|UniProtKB:Q6ZVK8}.
uniprot
proteins
mass_dalton
35647
uniprot
proteins
protein_family
Nudix hydrolase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
323
uniprot
proteins