CIDEA
entrez
1149
canonical
uniprot
O60543
canonical
ensembl
ENSG00000176194
resolver
ensp
ENSP00000320209
resolver
enst
ENST00000320477
resolver
genesymbol
CIDEA
resolver
hgnc
HGNC:1976
resolver
uniprot
B0YIY7
resolver
uniprot
B3KVA2
resolver
uniprot
Q6UPR7
resolver
uniprot
Q8N5P9
resolver
uniprot_entry
B3KVA2_HUMAN
resolver
uniprot_entry
CIDEA_HUMAN
resolver
uniprot_entry
Q8N5P9_HUMAN
resolver
uniprot_sec
B0YIY7
resolver
uniprot_sec
Q6UPR7
resolver
amino_acid_sequence
MEAARDYAGALIRPLTFMGSQTKRVLFTPLMHPARPFRVSNHDRSSRRGVMASSLQELISKTLDALVIATGLVTLVLEEDGTVVDTEEFFQTLGDNTHFMILEKGQKWMPGSQHVPTCSPPKRSGIARVTFDLYRLNPKDFIGCLNVKATMYEMYSVSYDIRCTGLKGLLRSLLRFLSYSAQVTGQFLIYLGTYMLRVLDDKEERPSLRSQAKGRFTCG
uniprot
proteins
disease_involvement
DISEASE: Note=In omental and subcutaneous adipose tissue of obese patients matched for BMI, expression levels correlate with insulin sensitivity. Expression is increased 5-6 fold in the group of patients with high insulin sensitivity, compared to the insulin-resistant group. This observation is consistent with the idea that triglyceride storage in adipocytes plays an important role in sequestering triglycerides and fatty acids away from the circulation and peripheral tissues, thus enhancing insulin sensitivity in liver and muscle. {ECO:0000269|PubMed:18509062}.
uniprot
proteins
function
FUNCTION: Lipid transferase that promotes unilocular lipid droplet formation by mediating lipid droplet fusion (PubMed:19843876, PubMed:26118629). Lipid droplet fusion promotes their enlargement, restricting lipolysis and favoring lipid storage (PubMed:19843876). Localizes on the lipid droplet surface, at focal contact sites between lipid droplets, and mediates atypical lipid droplet fusion by promoting directional net neutral lipid transfer from the smaller to larger lipid droplets (By similarity). The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC (By similarity). May also act as a CEBPB coactivator in epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein (By similarity). By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). When overexpressed, induces apoptosis; the physiological significance of its role in apoptosis is unclear (By similarity). {ECO:0000250|UniProtKB:O70302, ECO:0000269|PubMed:19843876, ECO:0000269|PubMed:26118629}.
uniprot
proteins
mass_dalton
24687
uniprot
proteins
protein_family
CIDE family
uniprot
proteins
pubmed
18509062
uniprot
proteins
pubmed
19843876
uniprot
proteins
pubmed
26118629
uniprot
proteins
pubmed
9564035
uniprot
proteins
sequence_length
219
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lipid droplet {ECO:0000269|PubMed:18509062}. Nucleus {ECO:0000250|UniProtKB:O70302}. Note=Enriched at lipid droplet contact sites. {ECO:0000269|PubMed:18509062}.
uniprot
proteins