ENO1
entrez
2023
canonical
uniprot
P06733
canonical
ensembl
ENSG00000074800
resolver
ensp
ENSP00000234590
resolver
ensp
ENSP00000495530
resolver
ensp
ENSP00000549757
resolver
ensp
ENSP00000605361
resolver
enst
ENST00000647408
resolver
enst
ENST00000879698
resolver
genesymbol
ENO1
resolver
genesymbol
HEL-S-17
resolver
genesymbol_syn
ENO1L1
resolver
genesymbol_syn
MBPB1
resolver
genesymbol_syn
MPB1
resolver
hgnc
HGNC:3350
resolver
uniprot
A0A024R4F1
resolver
uniprot
A0A0K0K1K8
resolver
uniprot
A0A2R8Y6G6
resolver
uniprot
B2RD59
resolver
uniprot
P22712
resolver
uniprot
Q16704
resolver
uniprot
Q4TUS4
resolver
uniprot
Q53FT9
resolver
uniprot
Q53HR3
resolver
uniprot
Q658M5
resolver
uniprot
Q6GMP2
resolver
uniprot
Q71V37
resolver
uniprot
Q7Z3V6
resolver
uniprot
Q8WU71
resolver
uniprot
Q96GV1
resolver
uniprot
Q9BT62
resolver
uniprot
Q9UCH6
resolver
uniprot
Q9UM55
resolver
uniprot_entry
A0A024R4F1_HUMAN
resolver
uniprot_entry
A0A2R8Y6G6_HUMAN
resolver
uniprot_entry
ENOA_HUMAN
resolver
uniprot_sec
A0A0K0K1K8
resolver
uniprot_sec
B2RD59
resolver
uniprot_sec
P22712
resolver
uniprot_sec
Q16704
resolver
uniprot_sec
Q4TUS4
resolver
uniprot_sec
Q53FT9
resolver
uniprot_sec
Q53HR3
resolver
uniprot_sec
Q658M5
resolver
uniprot_sec
Q6GMP2
resolver
uniprot_sec
Q71V37
resolver
uniprot_sec
Q7Z3V6
resolver
uniprot_sec
Q8WU71
resolver
uniprot_sec
Q96GV1
resolver
uniprot_sec
Q9BT62
resolver
uniprot_sec
Q9UCH6
resolver
uniprot_sec
Q9UM55
resolver
amino_acid_sequence
MSILKIHAREIFDSRGNPTVEVDLFTSKGLFRAAVPSGASTGIYEALELRDNDKTRYMGKGVSKAVEHINKTIAPALVSKKLNVTEQEKIDKLMIEMDGTENKSKFGANAILGVSLAVCKAGAVEKGVPLYRHIADLAGNSEVILPVPAFNVINGGSHAGNKLAMQEFMILPVGAANFREAMRIGAEVYHNLKNVIKEKYGKDATNVGDEGGFAPNILENKEGLELLKTAIGKAGYTDKVVIGMDVAASEFFRSGKYDLDFKSPDDPSRYISPDQLADLYKSFIKDYPVVSIEDPFDQDDWGAWQKFTASAGIQVVGDDLTVTNPKRIAKAVNEKSCNCLLLKVNQIGSVTESLQACKLAQANGWGVMVSHRSGETEDTFIADLVVGLCTGQIKTGAPCRSERLAKYNQLLRIEEELGSKAKFAGRNFRNPLAK
uniprot
proteins
ec_number
4.2.1.11
uniprot
proteins
function
FUNCTION: Enolase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in glycolysis and the reverse reaction in gluconeogenesis (PubMed:1369209, PubMed:29775581). Also involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:10802057, PubMed:12666133, PubMed:2005901, PubMed:29775581). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (PubMed:12666133). Stimulates immunoglobulin production (PubMed:1369209). {ECO:0000269|PubMed:10802057, ECO:0000269|PubMed:12666133, ECO:0000269|PubMed:1369209, ECO:0000269|PubMed:2005901, ECO:0000269|PubMed:29775581}.; FUNCTION: [Isoform MBP-1]: Binds to the myc promoter and acts as a transcriptional repressor. May be a tumor suppressor. {ECO:0000269|PubMed:10082554}.
uniprot
proteins
mass_dalton
47169
uniprot
proteins
mutagenesis
MUTAGEN 94; /note="M->I: MBP1 protein production. No MBP1 protein production; when associated with I-97."; /evidence="ECO:0000269|PubMed:10681589"; MUTAGEN 97; /note="M->I: MBP1 protein production. No MBP1 protein production; when associated with I-94."; /evidence="ECO:0000269|PubMed:10681589"; MUTAGEN 281; /note="K->R: Decreased 2-hydroxyisobutyrylation leading to decreased phosphopyruvate hydratase activity."; /evidence="ECO:0000269|PubMed:29775581"; MUTAGEN 384; /note="L->A: Loss of transcriptional repression and cell growth inhibition; when associated with A-388."; /evidence="ECO:0000269|PubMed:10082554"; MUTAGEN 388; /note="L->A: Loss of transcriptional repression and cell growth inhibition; when associated with A-384."; /evidence="ECO:0000269|PubMed:10082554
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5. {ECO:0000305|PubMed:1369209}.
uniprot
proteins
post_translational_modification
PTM: ISGylated. {ECO:0000269|PubMed:16139798, ECO:0000269|PubMed:16815975}.; PTM: Lysine 2-hydroxyisobutyrylation (Khib) by p300/EP300 activates the phosphopyruvate hydratase activity. {ECO:0000269|PubMed:29775581}.
uniprot
proteins
protein_family
Enolase family
uniprot
proteins
pubmed
10082554
uniprot
proteins
pubmed
10681589
uniprot
proteins
pubmed
10802057
uniprot
proteins
pubmed
11134351
uniprot
proteins
pubmed
11497239
uniprot
proteins
pubmed
12297304
uniprot
proteins
pubmed
12666133
uniprot
proteins
pubmed
1369209
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16139798
uniprot
proteins
pubmed
16548883
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16815975
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18560153
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
2005901
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21908771
uniprot
proteins
pubmed
22905912
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2373081
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28813417
uniprot
proteins
pubmed
29775581
uniprot
proteins
pubmed
3529090
uniprot
proteins
pubmed
7787969
uniprot
proteins
pubmed
8824716
uniprot
proteins
pubmed
9110174
uniprot
proteins
pubmed
9150948
uniprot
proteins
pubmed
9308760
uniprot
proteins
pubmed
9653645
uniprot
proteins
pubmed
9878089
uniprot
proteins
sequence_length
434
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10802057}. Cell membrane {ECO:0000269|PubMed:10802057}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000269|PubMed:10802057}. Note=Can translocate to the plasma membrane in either the homodimeric (alpha/alpha) or heterodimeric (alpha/gamma) form. ENO1 is localized to the M line.; SUBCELLULAR LOCATION: [Isoform MBP-1]: Nucleus.
uniprot
proteins