Pcgf1
entrez
69837
canonical
uniprot
Q8R023
canonical
ensembl
ENSMUSG00000069678
resolver
ensp
ENSMUSP00000090277
resolver
ensp
ENSMUSP00000130614
resolver
ensp
ENSMUSP00000135291
resolver
enst
ENSMUST00000092614
resolver
enst
ENSMUST00000165164
resolver
enst
ENSMUST00000177177
resolver
genesymbol
Pcgf1
resolver
genesymbol_syn
Nspc1
resolver
genesymbol_syn
Rnf68
resolver
uniprot
A0A0R4J141
resolver
uniprot
H3BK85
resolver
uniprot_entry
A0A0R4J141_MOUSE
resolver
uniprot_entry
H3BK85_MOUSE
resolver
uniprot_entry
PCGF1_MOUSE
resolver
amino_acid_sequence
MASPQGGQIAIAMRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTITECLHTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSEEKRIREFYQSRGLDRVSQPSGEEPALSNLGLPFSSFDHSKAHYYRYDEQLSLCLERLSSGKDKNKNVLQNKYVRCSVRAEVRHLRRVLCHRLMLNPQHVQLLFDNEVLPDHMTMKQLWLSRWFGKPSPLLLQYSVKEKRR
uniprot
proteins
function
FUNCTION: Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells. {ECO:0000250|UniProtKB:Q9BSM1}.
uniprot
proteins
mass_dalton
30318
uniprot
proteins
pubmed
11287196
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
259
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BSM1}.
uniprot
proteins