Adgrl1
entrez
330814
canonical
uniprot
Q80TR1
canonical
ensembl
ENSMUSG00000013033
resolver
ensp
ENSMUSP00000048422
resolver
ensp
ENSMUSP00000118452
resolver
ensp
ENSMUSP00000118579
resolver
enst
ENSMUST00000045393
resolver
genesymbol
Adgrl1
resolver
genesymbol_syn
Kiaa0821
resolver
genesymbol_syn
Lec2
resolver
genesymbol_syn
Lphn1
resolver
uniprot
H7BX15
resolver
uniprot
Q3UH90
resolver
uniprot
Q7TNE5
resolver
uniprot
Q80T49
resolver
uniprot_entry
AGRL1_MOUSE
resolver
uniprot_entry
H7BX15_MOUSE
resolver
uniprot_sec
Q3UH90
resolver
uniprot_sec
Q7TNE5
resolver
uniprot_sec
Q80T49
resolver
amino_acid_sequence
MARLAAALWSLCVTTVLVTSATQGLSRAGLPFGLMRRELACEGYPIELRCPGSDVIMVENANYGRTDDKICDADPFQMENVQCYLPDAFKIMSQRCNNRTQCVVVAGSDAFPDPCPGTYKYLEVQYDCVPYIFVCPGTLQKVLEPTSTHESEHQSGAWCKDPLQAGDRIYVMPWIPYRTDTLTEYASWEDYVAARHTTTYRLPNRVDGTGFVVYDGAVFYNKERTRNIVKYDLRTRIKSGETVINTANYHDTSPYRWGGKTDIDLAVDENGLWVIYATEGNNGRLVVSQLNPYTLRFEGTWETGYDKRSASNAFMVCGVLYVLRSVYVDDDSEAAGNRVDYAFNTNANREEPVSLAFPNPYQFVSSVDYNPRDNQLYVWNNYFVVRYSLEFGPPDPSAGPATSPPLSTTTTARPTPLTSTASPAATTPLRRAPLTTHPVGAINQLGPDLPPATAPAPSTRRPPAPNLHVSPELFCEPREVRRVQWPATQQGMLVERPCPKGTRGIASFQCLPALGLWNPRGPDLSNCTSPWVNQVAQKIKSGENAANIASELARHTRGSIYAGDVSSSVKLMEQLLDILDAQLQALRPIERESAGKNYNKMHKRERTCKDYIKAVVETVDNLLRPEALESWKDMNATEQVHTATMLLDVLEEGAFLLADNVREPARFLAAKQNVVLEVTVLNTEGQVQELVFPQEYPSENSIQLSANTIKQNSRNGVVKVVFILYNNLGLFLSTENATVKLAGEAGTGGPGGASLVVNSQVIAASINKESSRVFLMDPVIFTVAHLEAKNHFNANCSFWNYSERSMLGYWSTQGCRLVESNKTHTTCACSHLTNFAVLMAHREIYQGRINELLLSVITWVGIVISLVCLAICISTFCFLRGLQTDRNTIHKNLCINLFLAELLFLVGIDKTQYEVACPIFAGLLHYFFLAAFSWLCLEGVHLYLLLVEVFESEYSRTKYYYLGGYCFPALVVGIAAAIDYRSYGTEKACWLRVDNYFIWSFIGPVSFVIVVNLVFLMVTLHKMIRSSSVLKPDSSRLDNIKSWALGAIALLFLLGLTWAFGLLFINKESVVMAYLFTTFNAFQGVFIFVFHCALQKKVHKEYSKCLRHSYCCIRSPPGGTHGSLKTSAMRSNTRYYTGTQSRIRRMWNDTVRKQTESSFMAGDINSTPTLNRGTMGNHLLTNPVLQPRGGTSPYNTLIAESVGFNPSSPPVFNSPGSYREPKHPLGGREACGMDTLPLNGNFNNSYSLRSGDFPPGDGGPEPPRGRNLADAAAFEKMIISELVHNNLRGASGGAKGPPPEPPVPPVPGVSEDEAGGPGSADRAEIELLYKALEEPLLLPRAQSVLYQSDLDESESCTAEDGATSRPLSSPPGRDSLYASGANLRDSPSYPDSSPEGPNEALPPPPPAPPGPPEIYYTSRPPALVARNPLQGYYQVRRPSHEGYLAAPSLEGPGPDGDGQMQLVTSL
uniprot
proteins
function
FUNCTION: Calcium-independent receptor of high affinity for alpha-latrotoxin, an excitatory neurotoxin present in black widow spider venom which triggers massive exocytosis from neurons and neuroendocrine cells (PubMed:35907405). Receptor for TENM2 that mediates heterophilic synaptic cell-cell contact and postsynaptic specialization. Receptor probably implicated in the regulation of exocytosis (By similarity). {ECO:0000250|UniProtKB:O88917, ECO:0000269|PubMed:35907405}.
uniprot
proteins
mass_dalton
161686
uniprot
proteins
mutagenesis
MUTAGEN 42; /note="E->A,R: Abrogates L-rhamnose binding."; /evidence="ECO:0000269|PubMed:18547526"; MUTAGEN 42; /note="E->D,Q: 100-fold decreased affinity for L-rhamnose."; /evidence="ECO:0000269|PubMed:18547526"; MUTAGEN 120; /note="K->A,R: Abrogates L-rhamnose binding."; /evidence="ECO:0000269|PubMed:18547526
uniprot
proteins
post_translational_modification
PTM: Autoproteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. This proteolytic processing takes place early in the biosynthetic pathway, either in the endoplasmic reticulum or in the early compartment of the Golgi apparatus. {ECO:0000250|UniProtKB:O88917}.
uniprot
proteins
protein_family
Adhesion G protein-coupled receptor (ADGR) subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 2 family
uniprot
proteins
pubmed
12679517
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18547526
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22405201
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
35907405
uniprot
proteins
sequence_length
1466
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell projection, axon {ECO:0000250|UniProtKB:O88917}. Cell projection, growth cone {ECO:0000250|UniProtKB:O88917}. Synapse {ECO:0000250|UniProtKB:O88917}. Presynaptic cell membrane {ECO:0000250|UniProtKB:O88917}. Synapse, synaptosome {ECO:0000250|UniProtKB:O88917}. Note=Colocalizes with TENM2 on the cell surface, across intercellular junctions and on nerve terminals near synaptic clefts. {ECO:0000250|UniProtKB:O88917}.
uniprot
proteins
transmembrane_region
TRANSMEM 853..873; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 888..908; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 915..935; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 959..979; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 997..1017; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 1045..1065; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 1070..1090; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins