SPRY3
entrez
10251
canonical
uniprot
O43610
canonical
ensembl
ENSG00000168939
resolver
ensp
ENSP00000302978
resolver
ensp
ENSP00000502489
resolver
ensp
ENSP00000511806
resolver
ensp
ENSP00000572858
resolver
ensp
ENSP00000572859
resolver
ensp
ENSP00000599674
resolver
ensp
ENSP00000599675
resolver
enst
ENST00000302805
resolver
enst
ENST00000675360
resolver
enst
ENST00000695325
resolver
enst
ENST00000902799
resolver
enst
ENST00000902800
resolver
enst
ENST00000929615
resolver
enst
ENST00000929616
resolver
genesymbol
SPRY3
resolver
hgnc
HGNC:11271
resolver
uniprot
A8K0H8
resolver
uniprot
Q6ZUP3
resolver
uniprot_entry
Q6ZUP3_HUMAN
resolver
uniprot_entry
SPY3_HUMAN
resolver
uniprot_sec
A8K0H8
resolver
amino_acid_sequence
MDAAVTDDFQQILPIEQLRSTHASNDYVERPPAPCKQALSSPSLIVQTHKSDWSLATMPTSLPRSLSQCHQLQPLPQHLSQSSIASSMSHSTTASDQRLLASITPSPSGQSIIRTQPGAGVHPKADGALKGEAEQSAGHPSEHLFICEECGRCKCVPCTAARPLPSCWLCNQRCLCSAESLLDYGTCLCCVKGLFYHCSTDDEDNCADEPCSCGPSSCFVRWAAMSLISLFLPCLCCYLPTRGCLHLCQQGYDSLRRPGCRCKRHTNTVCRKISSGSAPFPKAQEKSV
uniprot
proteins
function
FUNCTION: Inhibits neurite branching, arbor length and neurite complexity (By similarity). Inhibits EGF-mediated p42/44 ERK signaling (By similarity). Negatively regulates the MAPK cascade, resulting in a reduction of extracellular matrix protein accumulation (PubMed:30878395). May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis (PubMed:9458049). {ECO:0000250|UniProtKB:Q3UUD2, ECO:0000269|PubMed:30878395, ECO:0000269|PubMed:9458049}.
uniprot
proteins
mass_dalton
31222
uniprot
proteins
protein_family
Sprouty family
uniprot
proteins
pubmed
10655549
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
17974561
uniprot
proteins
pubmed
26089202
uniprot
proteins
pubmed
29293652
uniprot
proteins
pubmed
30878395
uniprot
proteins
pubmed
9458049
uniprot
proteins
sequence_length
288
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins