Ccsap
entrez
73420
canonical
uniprot
Q8QZT2
canonical
ensembl
ENSMUSG00000031971
resolver
ensp
ENSMUSP00000034452
resolver
ensp
ENSMUSP00000113319
resolver
enst
ENSMUST00000034452
resolver
enst
ENSMUST00000122421
resolver
genesymbol
Ccsap
resolver
uniprot
Q8C3E1
resolver
uniprot_entry
CCSAP_MOUSE
resolver
uniprot_sec
Q8C3E1
resolver
amino_acid_sequence
MSPGSGVKSEYMKRYREPRWDEYAPCYRELLRYRLGRRLLEQAHAPWLWDAWGPDSPSDSSASPSPAPRGALGEPSAPSAREEEQPVGERGAELRDAEEQDTVLPAPPKKDTEEKPEEHKTKETDGAPSGPGPRQQPSALCARGSKKATRSPQRSTSKIKENKHPFALYGWGERQMDMGSQKTHNVCASASVHEIHESALRAKNRRQVEKRKLAAQRQRAHSVDVEKNQRVKPASAENPWLTEYMRCYSARA
uniprot
proteins
function
FUNCTION: Plays a role in microtubule (MT) stabilization and this stabilization involves the maintenance of NUMA1 at the spindle poles. Colocalizes with polyglutamylated MTs to promote MT stabilization and regulate bipolar spindle formation in mitosis. Binding of CCSAP to centrosomes and the spindle around centrosomes during mitosis inhibits MT depolymerization, thereby stabilizing the mitotic spindle. May play a role in embryonic development. May be required for proper cilia beating (By similarity). {ECO:0000250|UniProtKB:Q6IQ19, ECO:0000250|UniProtKB:Q6P3G4}.
uniprot
proteins
mass_dalton
28379
uniprot
proteins
protein_family
CCSAP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
252
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q6IQ19}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q6IQ19}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q6IQ19}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q6IQ19}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q6IQ19}. Cell projection, axon {ECO:0000250|UniProtKB:Q6IQ19}. Cell projection, cilium {ECO:0000250|UniProtKB:Q6IQ19}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q6IQ19}. Note=Localizes to two to four centrioles throughout the cell cycle. Localizes to mitotic spindle microtubules during prometaphase and throughout the remainder of mitosis. Localizes to cytoskeleton on interphase. Localizes at the ciliary transition zone which connects the basal bodies to ciliary microtubules. Colocalizes with polyglutamylated tubulin (By similarity). {ECO:0000250|UniProtKB:Q6IQ19}.
uniprot
proteins