Atoh8
entrez
71093
canonical
uniprot
Q99NA2
canonical
ensembl
ENSMUSG00000037621
resolver
ensp
ENSMUSP00000036981
resolver
enst
ENSMUST00000042646
resolver
genesymbol
Atoh8
resolver
genesymbol_syn
Ath6
resolver
uniprot
Q8C1I7
resolver
uniprot_entry
ATOH8_MOUSE
resolver
uniprot_sec
Q8C1I7
resolver
amino_acid_sequence
MKHIPVLEDGPWKTVCVKELNGLKKLKRKGKEPVRRANGYKTFRLDLEAPELGATVSTTAATNGLRDRTQPFPIATPVPASVAPAVPPGGGTDTAREFRGIRAPEVSDARKRGFALGTVGPGLPTPPPPPASQSLAPGDPEAHSFREQALRPRILLCAPPARPTQSAPLAPPAAPQESPVRPAPPTRPGESSYSSISHVIYNNHPDSSASPRKRPGEATAASTEIKALQQTRRLLANARERTRVHTISAAFEALRKQVPCYSYGQKLSKLAILRIACNYILSLARLADLDYSADHSNLSFSECVQRCTRTLQAEGRAKKRKE
uniprot
proteins
function
FUNCTION: Transcription factor that binds a palindromic (canonical) core consensus DNA sequence 5'-CANNTG- 3' known as an E-box element, possibly as a heterodimer with other bHLH proteins (By similarity). Regulates endothelial cell proliferation, migration and tube-like structures formation (By similarity). Modulates endothelial cell differentiation through NOS3 (By similarity). May be implicated in specification and differentiation of neuronal cell lineages in the brain (PubMed:11733035). May participate in kidney development and may be involved in podocyte differentiation (PubMed:16937370). During early embryonic development is involved in tissue-specific differentiation processes that are dependent on class II bHLH factors and namely modulates the differentiation program initiated by the pro-endocrine factor NEUROG3 (PubMed:18560595). During myogenesis, may play a role during the transition of myoblasts from the proliferative phase to the differentiation phase (PubMed:24186058). Positively regulates HAMP transcription in two ways, firstly by acting directly on the HAMP promoter via E-boxes binding and indirectly through increased phosphorylation of SMAD protein complex (By similarity). Repress NEUROG3-dependent gene activation in a gene-specific manner through at least two mechanisms; requires only either the sequestering of a general partner such as TCF3 through heterodimerization, either also requires binding of the bHLH domain to DNA via a basic motif (PubMed:23938248). {ECO:0000250|UniProtKB:Q96SQ7, ECO:0000269|PubMed:11733035, ECO:0000269|PubMed:16937370, ECO:0000269|PubMed:18560595, ECO:0000269|PubMed:23938248}.
uniprot
proteins
mass_dalton
34785
uniprot
proteins
pubmed
11733035
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16937370
uniprot
proteins
pubmed
18560595
uniprot
proteins
pubmed
23836893
uniprot
proteins
pubmed
23938248
uniprot
proteins
pubmed
24186058
uniprot
proteins
sequence_length
322
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24186058}. Nucleus speckle {ECO:0000250|UniProtKB:Q96SQ7}. Cytoplasm {ECO:0000269|PubMed:24186058}.
uniprot
proteins