Atg13
entrez
51897
canonical
uniprot
Q91YI1
canonical
ensembl
ENSMUSG00000027244
resolver
ensp
ENSMUSP00000028678
resolver
ensp
ENSMUSP00000076081
resolver
ensp
ENSMUSP00000210974
resolver
ensp
ENSMUSP00000210975
resolver
ensp
ENSMUSP00000210976
resolver
ensp
ENSMUSP00000210977
resolver
ensp
ENSMUSP00000210979
resolver
ensp
ENSMUSP00000210989
resolver
genesymbol
Atg13
resolver
genesymbol_syn
D2Ertd391e
resolver
genesymbol_syn
Kiaa0652
resolver
uniprot
A2AH18
resolver
uniprot
Q80TU9
resolver
uniprot_entry
ATG13_MOUSE
resolver
uniprot_sec
A2AH18
resolver
uniprot_sec
Q80TU9
resolver
amino_acid_sequence
METELSSQDRKDLDKFIKFFALKTVQVIVQARLGEKICTRSSSSPTGSDWFNLAIKDIPEVTHEAKKALSGQLPAVGRSMCVEISLKTSEGDSMELEIWCLEMNEKCDKEIKVSYTVYNRLSLLLKSLLAITRVTPAYRLSRKQGHEYVILYRIYFGEVQLNGLGEGFQTVRVGTVGTPVGTLTLSCAYRINLAFMSTRQFERTPPIMGIIIDHFVDRPYPSSSPMHPCNYRTAEDAGVAYPSVEDSQEVCTTSFSTSPPSQLSSSRLSYQPAVLGLGSADLAYPVVFTAGLNTTHAHQLMVPGKEGGVTLAPSHPTHGAQADPERLVMHMPSDGTHCAATPSSSEDTETVSNSSEGRASPHDILETIFVRKVGAFVNKPINQVTVTSLDIPFAMFAPKNLELEDADPMVNPPESPETTSPLHGSLHSDGSSGGSGGSTHDDFVMIDFKPAFSKDDILPMDLGTFYREFQNPPQLSSLSIDFGAQSMAEDLDSLPEKLAVHEKNVREFDAFVETLQ
uniprot
proteins
function
FUNCTION: Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation. {ECO:0000269|PubMed:19258318}.
uniprot
proteins
mass_dalton
56441
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by ULK1, ULK2 and mTOR. Phosphorylation status depends on nutrient-rich conditions; dephosphorylated during starvation or following treatment with rapamycin. ULK1-mediated phosphorylation of ATG13 at Ser-354 is required for efficient clearance of depolarized mitochondria. {ECO:0000250|UniProtKB:O75143}.
uniprot
proteins
protein_family
ATG13 family
uniprot
proteins
protein_family
Metazoan subfamily
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19211835
uniprot
proteins
pubmed
19258318
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
516
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:19211835, ECO:0000269|PubMed:19258318}. Preautophagosomal structure {ECO:0000269|PubMed:19211835, ECO:0000269|PubMed:19258318}. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome. {ECO:0000269|PubMed:19211835, ECO:0000269|PubMed:19258318}.
uniprot
proteins