GRSF1
entrez
2926
canonical
uniprot
Q12849
canonical
ensembl
ENSG00000132463
resolver
ensp
ENSP00000254799
resolver
ensp
ENSP00000421789
resolver
ensp
ENSP00000425430
resolver
genesymbol
GRSF1
resolver
hgnc
HGNC:4610
resolver
uniprot
B3KPW0
resolver
uniprot
Q4W5S5
resolver
uniprot
Q6ZST3
resolver
uniprot
Q8IWD6
resolver
uniprot
Q8NBD2
resolver
uniprot_entry
GRSF1_HUMAN
resolver
uniprot_sec
B3KPW0
resolver
uniprot_sec
Q4W5S5
resolver
uniprot_sec
Q6ZST3
resolver
uniprot_sec
Q8IWD6
resolver
uniprot_sec
Q8NBD2
resolver
amino_acid_sequence
MAGTRWVLGALLRGCGCNCSSCRRTGAACLPFYSAAGSIPSGVSGRRRLLLLLGAAAAAASQTRGLQTGPVPPGRLAGPPAVATSAAAAAAASYSALRASLLPQSLAAAAAVPTRSYSQESKTTYLEDLPPPPEYELAPSKLEEEVDDVFLIRAQGLPWSCTMEDVLNFFSDCRIRNGENGIHFLLNRDGKRRGDALIEMESEQDVQKALEKHRMYMGQRYVEVYEINNEDVDALMKSLQVKSSPVVNDGVVRLRGLPYSCNEKDIVDFFAGLNIVDITFVMDYRGRRKTGEAYVQFEEPEMANQALLKHREEIGNRYIEIFPSRRNEVRTHVGSYKGKKIASFPTAKYITEPEMVFEEHEVNEDIQPMTAFESEKEIELPKEVPEKLPEAADFGTTSSLHFVHMRGLPFQANAQDIINFFAPLKPVRITMEYSSSGKATGEADVHFETHEDAVAAMLKDRSHVHHRYIELFLNSCPKGK
uniprot
proteins
function
FUNCTION: Regulator of post-transcriptional mitochondrial gene expression, required for assembly of the mitochondrial ribosome and for recruitment of mRNA and lncRNA. Binds RNAs containing the 14 base G-rich element. Preferentially binds RNAs transcribed from three contiguous genes on the light strand of mtDNA, the ND6 mRNA, and the long non-coding RNAs for MT-CYB and MT-ND5, each of which contains multiple consensus binding sequences (PubMed:23473033, PubMed:23473034, PubMed:29967381). Involved in the degradosome-mediated decay of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). Acts by unwinding G-quadruplex RNA structures in MT-ncRNA, thus facilitating their degradation by the degradosome (PubMed:29967381). G-quadruplexes (G4) are non-canonical 4 stranded structures formed by transcripts from the light strand of mtDNA (PubMed:29967381). {ECO:0000269|PubMed:23473033, ECO:0000269|PubMed:23473034, ECO:0000269|PubMed:29967381}.
uniprot
proteins
mass_dalton
53126
uniprot
proteins
mutagenesis
MUTAGEN 155; /note="Q->A: Impairs RNA-binding and melting of G-quadruplex RNA structures; when associated with A-159; A-223; A-255; A-259; A-320; A-406; A-410 and A-470."; MUTAGEN 159; /note="W->A: Impairs RNA-binding and melting of G-quadruplex RNA structures; when associated with A-155; A-223; A-255; A-259; A-320; A-406; A-410 and A-470."; MUTAGEN 223; /note="E->A: Impairs RNA-binding and melting of G-quadruplex RNA structures; when associated with A-155; A-159; A-255; A-259; A-320; A-406; A-410 and A-470."; MUTAGEN 255; /note="R->A: Impairs RNA-binding and melting of G-quadruplex RNA structures; when associated with A-155; A-159; A-223; A-259; A-320; A-406; A-410 and A-470."; MUTAGEN 259; /note="Y->A: Impairs RNA-binding and melting of G-quadruplex RNA structures; when associated with A-155; A-159; A-223; A-255; A-320; A-406; A-410 and A-470."; MUTAGEN 320; /note="E->A: Impairs RNA-binding and melting of G-quadruplex RNA structures; when associated with A-155; A-159; A-223; A-255; A-259; A-406; A-410 and A-470."; MUTAGEN 406; /note="R->A: Impairs RNA-binding and melting of G-quadruplex RNA structures; when associated with A-155; A-159; A-223; A-255; A-259; A-320; A-410 and A-470."; MUTAGEN 410; /note="F->A: Impairs RNA-binding and melting of G-quadruplex RNA structures; when associated with A-155; A-159; A-223; A-255; A-259; A-320; A-406 and A-470."; MUTAGEN 470; /note="E->A: Impairs RNA-binding and melting of G-quadruplex RNA structures; when associated with A-155; A-159; A-223; A-255; A-259; A-320; A-406 and A-410.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23473033
uniprot
proteins
pubmed
23473034
uniprot
proteins
pubmed
25683715
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29967381
uniprot
proteins
pubmed
8036161
uniprot
proteins
sequence_length
480
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion matrix {ECO:0000269|PubMed:23473033, ECO:0000269|PubMed:23473034, ECO:0000269|PubMed:25683715, ECO:0000269|PubMed:29967381}. Note=Localizes to mitochondrial RNA granules found in close proximity to the mitochondrial nucleoids. {ECO:0000269|PubMed:23473033, ECO:0000269|PubMed:23473034, ECO:0000269|PubMed:25683715}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:23473034}.
uniprot
proteins