IL4
entrez
3565
canonical
uniprot
P05112
canonical
ensembl
ENSG00000113520
resolver
ensp
ENSP00000231449
resolver
ensp
ENSP00000325190
resolver
ensp
ENSP00000480581
resolver
enst
ENST00000622422
resolver
genesymbol
IL4
resolver
hgnc
HGNC:6014
resolver
uniprot
A0A087WWX8
resolver
uniprot
D4HNR6
resolver
uniprot
Q14630
resolver
uniprot
Q5FC01
resolver
uniprot
Q6NZ77
resolver
uniprot
U3LVN1
resolver
uniprot_entry
A0A087WWX8_HUMAN
resolver
uniprot_entry
D4HNR6_HUMAN
resolver
uniprot_entry
IL4_HUMAN
resolver
uniprot_entry
Q5FC01_HUMAN
resolver
uniprot_entry
U3LVN1_HUMAN
resolver
uniprot_sec
Q14630
resolver
uniprot_sec
Q6NZ77
resolver
amino_acid_sequence
MGLTSQLLPPLFFLLACAGNFVHGHKCDITLQEIIKTLNSLTEQKTLCTELTVTDIFAASKNTTEKETFCRAATVLRQFYSHHEKDTRCLGATAQQFHRHKQLIRFLKRLDRNLWGLAGLNSCPVKEANQSTLENFLERLKTIMREKYSKCSS
uniprot
proteins
disease_involvement
DISEASE: Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. {ECO:0000269|PubMed:14681304}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses (PubMed:1993171, PubMed:3016727). Induces the expression of class II MHC molecules on resting B-cells. Enhances both secretion and cell surface expression of IgE and IgG1 (PubMed:1993171). Also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes (PubMed:2521231). Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. In addition, plays a critical role in higher functions of the normal brain, such as memory and learning (By similarity). Upon binding to IL4, IL4R receptor dimerizes either with the common IL2R gamma chain/IL2RG to produce the type 1 signaling complex, located mainly on hematopoietic cells, or with the IL13RA1 to produce the type 2 complex, which is also expressed on nonhematopoietic cells (PubMed:10219247, PubMed:11526337, PubMed:18243101). Engagement of both types of receptors initiates JAK3 and to a lower extend JAK1 phosphorylation leading to activation of the signal transducer and activator of transcription 6/STAT6 (PubMed:7721895). {ECO:0000250|UniProtKB:P07750, ECO:0000269|PubMed:10219247, ECO:0000269|PubMed:11526337, ECO:0000269|PubMed:18243101}.
uniprot
proteins
mass_dalton
17492
uniprot
proteins
mutagenesis
MUTAGEN 33; /note="E->A: About 500-fold lower interaction with IL4R than WT."; /evidence="ECO:0000269|PubMed:11526337
uniprot
proteins
protein_family
IL-4/IL-13 family
uniprot
proteins
pubmed
10219247
uniprot
proteins
pubmed
11526337
uniprot
proteins
pubmed
1400355
uniprot
proteins
pubmed
14681304
uniprot
proteins
pubmed
1511746
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1567880
uniprot
proteins
pubmed
1567881
uniprot
proteins
pubmed
1569578
uniprot
proteins
pubmed
1609277
uniprot
proteins
pubmed
18243101
uniprot
proteins
pubmed
1932028
uniprot
proteins
pubmed
1946344
uniprot
proteins
pubmed
1993171
uniprot
proteins
pubmed
2521231
uniprot
proteins
pubmed
2535858
uniprot
proteins
pubmed
2971718
uniprot
proteins
pubmed
3016727
uniprot
proteins
pubmed
3257560
uniprot
proteins
pubmed
7664036
uniprot
proteins
pubmed
7721895
uniprot
proteins
pubmed
7806280
uniprot
proteins
pubmed
8151703
uniprot
proteins
sequence_length
153
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins