INTS14
entrez
81556
canonical
uniprot
Q96SY0
canonical
ensembl
ENSG00000138614
resolver
ensp
ENSP00000326379
resolver
ensp
ENSP00000396314
resolver
ensp
ENSP00000402898
resolver
ensp
ENSP00000408429
resolver
ensp
ENSP00000456460
resolver
ensp
ENSP00000457624
resolver
ensp
ENSP00000590205
resolver
ensp
ENSP00000590206
resolver
ensp
ENSP00000590207
resolver
ensp
ENSP00000692312
resolver
enst
ENST00000442903
resolver
enst
ENST00000567744
resolver
enst
ENST00000569491
resolver
enst
ENST00000920146
resolver
genesymbol
INTS14
resolver
genesymbol_syn
C15orf44
resolver
genesymbol_syn
VWA9
resolver
hgnc
HGNC:25372
resolver
uniprot
A0ACI8T0T6
resolver
uniprot
B4DDI6
resolver
uniprot
B4DJL6
resolver
uniprot
B4DVD5
resolver
uniprot
B4DVT3
resolver
uniprot
B4DWZ3
resolver
uniprot
H3BRY6
resolver
uniprot
H3BUG5
resolver
uniprot
Q49AH8
resolver
uniprot
Q96HX5
resolver
uniprot
Q9H0S5
resolver
uniprot_entry
A0ACI8T0T6_HUMAN
resolver
uniprot_entry
B4DJL6_HUMAN
resolver
uniprot_entry
B4DVT3_HUMAN
resolver
uniprot_entry
B4DWZ3_HUMAN
resolver
uniprot_entry
H3BRY6_HUMAN
resolver
uniprot_entry
H3BUG5_HUMAN
resolver
uniprot_entry
INT14_HUMAN
resolver
uniprot_sec
B4DDI6
resolver
uniprot_sec
B4DVD5
resolver
uniprot_sec
Q49AH8
resolver
uniprot_sec
Q96HX5
resolver
uniprot_sec
Q9H0S5
resolver
amino_acid_sequence
MPTVVVMDVSLSMTRPVSIEGSEEYQRKHLAAHGLTMLFEHMATNYKLEFTALVVFSSLWELMVPFTRDYNTLQEALSNMDDYDKTCLESALVGVCNIVQQEWGGAIPCQVVLVTDGCLGIGRGSLRHSLATQNQRSESNRFPLPFPFPSKLYIMCMANLEELQSTDSLECLERLIDLNNGEGQIFTIDGPLCLKNVQSMFGKLIDLAYTPFHAVLKCGHLTADVQVFPRPEPFVVDEEIDPIPKVINTDLEIVGFIDIADISSPPVLSRHLVLPIALNKEGDEVGTGITDDNEDENSANQIAGKIPNFCVLLHGSLKVEGMVAIVQLGPEWHGMLYSQADSKKKSNLMMSLFEPGPEPLPWLGKMAQLGPISDAKENPYGEDDNKSPFPLQPKNKRSYAQNVTVWIKPSGLQTDVQKILRNARKLPEKTQTFYKELNRLRKAALAFGFLDLLKGVADMLERECTLLPETAHPDAAFQLTHAAQQLKLASTGTSEYAAYDQNITPLHTDFSGSSTERI
uniprot
proteins
function
FUNCTION: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:38570683, PubMed:38823386). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:32647223). Within the integrator complex, INTS14 is part of the integrator tail module that acts as a platform for the recruitment of transcription factors at promoters (PubMed:38823386, PubMed:38906142). {ECO:0000269|PubMed:32647223, ECO:0000269|PubMed:38570683, ECO:0000269|PubMed:38823386, ECO:0000269|PubMed:38906142}.
uniprot
proteins
mass_dalton
57471
uniprot
proteins
mutagenesis
MUTAGEN 8..12; /note="DVSLS->AVALA: Abolished interaction with INTS10."; /evidence="ECO:0000269|PubMed:36920904"; MUTAGEN 11..15; /note="LSMTR->ESMTA: Abolished interaction with INTS10."; /evidence="ECO:0000269|PubMed:36920904
uniprot
proteins
protein_family
Integrator subunit 14 family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
19160420
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
32647223
uniprot
proteins
pubmed
36920904
uniprot
proteins
pubmed
38570683
uniprot
proteins
pubmed
38823386
uniprot
proteins
pubmed
38906142
uniprot
proteins
pubmed
39032490
uniprot
proteins
sequence_length
518
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:39032490}.
uniprot
proteins