Atp1a4
entrez
29132
canonical
uniprot
Q64541
canonical
ensembl
ENSRNOG00000032378
resolver
ensp
ENSRNOP00000062079
resolver
enst
ENSRNOT00000064601
resolver
genesymbol
Atp1a4
resolver
genesymbol_syn
Atp1al2
resolver
uniprot
A0A8L2UNF2
resolver
uniprot
Q5PQV3
resolver
uniprot_entry
A0A8L2UNF2_RAT
resolver
uniprot_entry
AT1A4_RAT
resolver
uniprot_entry
Q5PQV3_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Specifically inhibited by an endogenous cardiac glycoside, ouabain. {ECO:0000250|UniProtKB:Q13733}.
uniprot
proteins
amino_acid_sequence
MEPGKETAATSEQKPRPTLRASNTNRQPKVKRRKKDLEELKKEVVMDDHKLTLDELSAKYSVDLTKGLSVTDAQEILTLNGPNVLTPPPTTPEWIKFCKQLFGGFSLLLWTGSLLCFLAYGIHVSYYQENANKDNLYLGIVLSAVVIITGCFSYYQEAKSSKIMESFKTMVPQQALVIRDGEKMQINVRDVVLGDLVEVKGGDQVPADIRVIAAQGCKVDNSSLTGESEPQSRCPDCTHENPLETRNIIFFSTNCVEGTARGVVIATGDHTVMGRIASLTSGLTMGKTPIATEIEHFIHIITAVAVFLGVTFFFLSLILGYTWLDAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGSTSTICSDKTGTLTQNRMTVAHLWFDKTVYEADTSEEQTTGKTFPKSSDTWFYLARIAGLCNRADFKPHQESLPITKRTTTGDASESALLKFIEQSYSPVSEMRQKNPKVAEIPFNSTNKYQMSIHLLEDNSEAHVLLMKGAPERILDFCSSFLLNGQEYPMDEEMKTDFQNAYIELGGLGERVLGFCFLNLPSNFSKGFQFNTEELNFPMENLCFAGLISMIDPPRTAVPDAVSKCRSAGIKVIMVTGDHPITAKAIAKSVGIISEANETAEDIAARLNISISQVSNKSIKAIVVHGSELKDMDSGQLDNILKSYKEIVFARTSPQQKLIIVEGCQRLGAIVAVTGDGVNDSPALKKADIGIAMGITGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPFLLFIVLSIPLPLGTITILCIDLGTDMVPAISLAYETPESDIMKRLPRNPKTDNLVNDRLIGMAYGQIGMIQALAGFFTYFVILAENGFKPLDLLGIRLYWDDTNLNDLEDTYGQQWTYEQRKVVEFTCQTAFFISIVIVQWADLIICKTRRNSLFKQGMKNKVLIFGLLEETILAACLSYIPGMDVALRMYPLKINWWFCALPYSVLIFIYDEVRKLIIRRRPGGWLEKETYY
uniprot
proteins
ec_number
7.2.2.13
uniprot
proteins
function
FUNCTION: Sperm-specific catalytic alpha subunit of the Na(+)/K(+)-ATPase responsible for ATP-dependent Na(+)/K(+) exchange across the plasma membrane. Transports 3 Na(+) ions out of the cell and 2 K(+) ions into the cell for each ATP hydrolyze (PubMed:20179187). Plays an essential for sperm motility, capacitation, and male fertility by maintaining ionic gradients required for flagellar function and signaling (PubMed:20179187). {ECO:0000269|PubMed:20179187}.
uniprot
proteins
mass_dalton
114005
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type IIC subfamily
uniprot
proteins
pubmed
20179187
uniprot
proteins
pubmed
7809153
uniprot
proteins
sequence_length
1028
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q13733}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q13733}. Note=In mature sperm, located in the principle piece of the sperm flagellum. {ECO:0000250|UniProtKB:Q13733}.
uniprot
proteins
transmembrane_region
TRANSMEM 97..121; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q13733"; TRANSMEM 133..154; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q13733"; TRANSMEM 294..317; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q13733"; TRANSMEM 323..348; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q13733"; TRANSMEM 777..799; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q13733"; TRANSMEM 805..827; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q13733"; TRANSMEM 850..873; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q13733"; TRANSMEM 923..944; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q13733"; TRANSMEM 953..975; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q13733"; TRANSMEM 987..1012; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q13733
uniprot
proteins