CYP4F11
entrez
57834
canonical
uniprot
Q9HBI6
canonical
ensembl
ENSG00000171903
resolver
ensp
ENSP00000248041
resolver
ensp
ENSP00000384588
resolver
ensp
ENSP00000574177
resolver
ensp
ENSP00000574182
resolver
enst
ENST00000248041
resolver
enst
ENST00000402119
resolver
enst
ENST00000904118
resolver
enst
ENST00000904123
resolver
genesymbol
CYP4F11
resolver
hgnc
HGNC:13265
resolver
uniprot
A0A024R7G0
resolver
uniprot
A8K059
resolver
uniprot
O75254
resolver
uniprot
Q96AQ5
resolver
uniprot_entry
CP4FB_HUMAN
resolver
uniprot_sec
A0A024R7G0
resolver
uniprot_sec
A8K059
resolver
uniprot_sec
O75254
resolver
uniprot_sec
Q96AQ5
resolver
activity_regulation
ACTIVITY REGULATION: Inhibition of the long-chain fatty acid omega-monooxygenase activity by 4-hydroxynonenal (4-HNE) conjugation. {ECO:0000269|PubMed:37373382}.
uniprot
proteins
amino_acid_sequence
MPQLSLSWLGLGPVAASPWLLLLLVGGSWLLARVLAWTYTFYDNCRRLQCFPQPPKQNWFWGHQGLVTPTEEGMKTLTQLVTTYPQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYGFLKPWLGDGLLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHDKWQRLASEGSARLDMFEHISLMTLDSLQKCVFSFESNCQEKPSEYIAAILELSAFVEKRNQQILLHTDFLYYLTPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSKTLDFIDVLLLSKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCTQDFVLPDGRVIPKGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALTLLHFRILPTHTEPRRKPELILRAEGGLWLRVEPLGANSQ
uniprot
proteins
ec_number
1.14.14.1
uniprot
proteins
ec_number
1.14.14.78
uniprot
proteins
ec_number
1.14.14.79
uniprot
proteins
ec_number
1.14.14.80
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids and their oxygenated derivatives (oxylipins) (PubMed:15364545, PubMed:18065749, PubMed:24138531, PubMed:37373382). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:15364545, PubMed:18065749, PubMed:24138531, PubMed:37373382). Catalyzes with high efficiency the oxidation of the terminal carbon (omega-oxidation) of 3-hydroxy fatty acids, such as 3-hydroxyhexadecanoic and 3-hydroxyoctadecanoic acids, likely participating in the biosynthesis of long-chain 3-hydroxydicarboxylic acids (PubMed:18065749, PubMed:19932081). Omega-hydroxylates and inactivates phylloquinone (vitamin K1), and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulation (PubMed:24138531). Metabolizes with low efficiciency fatty acids, including (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) and its oxygenated metabolite 8-hydroxyeicosatetraenoic acid (8-HETE) (PubMed:15364545, PubMed:19932081). Catalyzes N- and O-demethylation of drugs such as erythromycin, benzphetamine, ethylmorphine, chlorpromazine, imipramine and verapamil (PubMed:15364545). Catalyzes the oxidation of dialkylresorcinol 2 (PubMed:36565673). {ECO:0000269|PubMed:15364545, ECO:0000269|PubMed:18065749, ECO:0000269|PubMed:19932081, ECO:0000269|PubMed:24138531, ECO:0000269|PubMed:36565673, ECO:0000269|PubMed:37373382}.
uniprot
proteins
mass_dalton
60146
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; arachidonate metabolism. {ECO:0000269|PubMed:15364545}.; PATHWAY: Lipid metabolism; oxylipin biosynthesis. {ECO:0000269|PubMed:15364545}.; PATHWAY: Cofactor degradation; phylloquinone degradation. {ECO:0000269|PubMed:24138531}.; PATHWAY: Xenobiotic degradation. {ECO:0000269|PubMed:15364545}.
uniprot
proteins
post_translational_modification
PTM: 4-hydroxynonenal conjugation impairs substrate binding and the long-chain fatty acid omega-monooxygenase activity. {ECO:0000269|PubMed:37373382}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
10964514
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15364545
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18065749
uniprot
proteins
pubmed
19932081
uniprot
proteins
pubmed
24138531
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
36565673
uniprot
proteins
pubmed
37373382
uniprot
proteins
sequence_length
524
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18065749}; Single-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000269|PubMed:18065749}; Single-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..37; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins