Rnf112
entrez
22671
canonical
uniprot
Q96DY5
canonical
ensembl
ENSMUSG00000010086
resolver
ensp
ENSMUSP00000056464
resolver
ensp
ENSMUSP00000059903
resolver
ensp
ENSMUSP00000099722
resolver
ensp
ENSMUSP00000200282
resolver
ensp
ENSMUSP00000200284
resolver
ensp
ENSMUSP00000200285
resolver
ensp
ENSMUSP00000200294
resolver
genesymbol
Rnf112
resolver
genesymbol_syn
Bfp
resolver
genesymbol_syn
Znf179
resolver
uniprot
Q3TNS6
resolver
uniprot
Q5NCN2
resolver
uniprot
Q8JZT5
resolver
uniprot
Q9Z328
resolver
uniprot_entry
RN112_MOUSE
resolver
uniprot_sec
Q3TNS6
resolver
uniprot_sec
Q5NCN2
resolver
uniprot_sec
Q8JZT5
resolver
uniprot_sec
Q9Z328
resolver
amino_acid_sequence
MPRPVLSVTAFCHRLGKRESKRSFMGNSSNSWVLPREEAQGWMGQAVQGGTRTSRSHASFPKLELGLGHRPSPTREPPTCSICLERLREPISLDCGHDFCIRCFSTHRIPGCELPCCPECRKICKQRKGLRSLGERMKLLPQRPLPPALQETCAVRAERLLLVRINASGGLILRMGAINRCLKHPLARDTPVCLLAVLGEQHSGKSFLLDHLLSGLPSLESGDSGRPRAEGSLPGIRWGANGLTRGIWMWSHPFLLGKEGKKVAVFLVDTGDVMSPELSKETRVKLCALTMMLSSYQILNTSQELKDTDLGYLEMFVHVAEVMGKHYGMVPIQHLDLLVRDSSHHNKSGQGHVGDILQKLSGKYPKVQELLLGKRARCYLLPAPERQWVNKDQASPRGNTEDDFSHHFRAYILDVLSTAPQHAKSRCQGYWSEGRAVARGDRRLLTGQQLAQEIKNLSGWMGKTGPSFNSPDEMAAQLHDLRKVEAAKKEFEEYVRQQDIATKRIFSALRVLPDTMRNLLSTQKDAILARHGVALLCKEREQTLEALEAELQAEAKAFMDSYTMRFCGHLAAVGGAVGAGLMGLAGGVVGAGMAAAALAAEAGMVAAGAAVGATGAAVVGGGVGAGLAATVGCMEKEEDERVQGGDREPLLQEE
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that plays an important role in neuronal differentiation, including neurogenesis and gliogenesis, during brain development. During embryonic development initiates neuronal differentiation by inducing cell cycle arrest at the G0/G1 phase through up-regulation of cell-cycle regulatory proteins (PubMed:21566658, PubMed:28684796). Plays a role not only in the fetal period during the development of the nervous system, but also in the adult brain, where it is involved in the maintenance of neural functions and protection of the nervous tissue cells from oxidative stress-induced damage (PubMed:26792191, PubMed:26951452, PubMed:27918959). Exhibits GTPase and E3 ubiquitin-protein ligase activities. Regulates dendritic spine density and synaptic neurotransmission; its ability to hydrolyze GTP is involved in the maintenance of dendritic spine density (PubMed:26212327). {ECO:0000269|PubMed:21566658, ECO:0000269|PubMed:26212327, ECO:0000269|PubMed:26792191, ECO:0000269|PubMed:26951452, ECO:0000269|PubMed:27918959, ECO:0000269|PubMed:28684796}.
uniprot
proteins
mass_dalton
71275
uniprot
proteins
mutagenesis
MUTAGEN 97; /note="H->N: Loss of endosomal localization."; /evidence="ECO:0000269|PubMed:26212327"; MUTAGEN 340; /note="R->Q: Reduced GTP-hydrolysis."; /evidence="ECO:0000269|PubMed:26212327
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000305}.
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated. {ECO:0000269|PubMed:26212327}.
uniprot
proteins
protein_family
GB1 subfamily
uniprot
proteins
protein_family
GB1/RHD3 GTPase family
uniprot
proteins
protein_family
TRAFAC class dynamin-like GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21566658
uniprot
proteins
pubmed
24359566
uniprot
proteins
pubmed
26212327
uniprot
proteins
pubmed
26792191
uniprot
proteins
pubmed
26951452
uniprot
proteins
pubmed
27918959
uniprot
proteins
pubmed
28684796
uniprot
proteins
pubmed
9806830
uniprot
proteins
sequence_length
654
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:26212327}; Multi-pass membrane protein {ECO:0000255}. Membrane {ECO:0000269|PubMed:26212327}; Peripheral membrane protein {ECO:0000269|PubMed:26212327}. Cytoplasm {ECO:0000269|PubMed:24359566, ECO:0000269|PubMed:27918959, ECO:0000269|PubMed:9806830}. Nucleus {ECO:0000269|PubMed:24359566, ECO:0000269|PubMed:26951452, ECO:0000269|PubMed:27918959, ECO:0000269|PubMed:9806830}. Nucleus, nuclear body {ECO:0000269|PubMed:24359566}. Nucleus, nucleoplasm {ECO:0000269|PubMed:24359566}. Endosome {ECO:0000269|PubMed:26212327}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000269|PubMed:26212327}. Postsynaptic density {ECO:0000269|PubMed:26212327}. Perikaryon {ECO:0000269|PubMed:26951452}. Cell projection, neuron projection {ECO:0000269|PubMed:26951452}. Note=Predominantly in the nucleus, but some amounts were also found in the cytoplasm (PubMed:24359566, PubMed:9806830). Oxidative stress stimulates its shuttling from the cytoplasm into the nucleus (PubMed:27918959). Recruited to nuclear bodies via its interaction with ZBTB16 (PubMed:24359566). Localizes to the cell soma and neuritis and only slightly to the nucleus in the neurons of most brain areas (PubMed:26951452). {ECO:0000269|PubMed:24359566, ECO:0000269|PubMed:26951452, ECO:0000269|PubMed:27918959, ECO:0000269|PubMed:9806830}.
uniprot
proteins
transmembrane_region
TRANSMEM 570..590; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 603..623; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins