Slc6a8
entrez
102857
canonical
uniprot
Q8VBW1
canonical
ensembl
ENSMUSG00000019558
resolver
ensp
ENSMUSP00000033752
resolver
ensp
ENSMUSP00000110109
resolver
ensp
ENSMUSP00000132921
resolver
genesymbol
Slc6a8
resolver
genesymbol_syn
Crt
resolver
uniprot
A2ALM4
resolver
uniprot
A2ALM6
resolver
uniprot
Q80YC9
resolver
uniprot
Q8K4R3
resolver
uniprot
Q8R1L0
resolver
uniprot_entry
A2ALM6_MOUSE
resolver
uniprot_entry
SC6A8_MOUSE
resolver
uniprot_sec
A2ALM4
resolver
uniprot_sec
Q80YC9
resolver
uniprot_sec
Q8K4R3
resolver
uniprot_sec
Q8R1L0
resolver
amino_acid_sequence
MAKKSAENGIYSVSGDEKKGPLIVSGPDGAPAKGDGPAGLGAPGGRLAVPPRETWTRQMDFIMSCVGFAVGLGNVWRFPYLCYKNGGGVFLIPYVLIALVGGIPIFFLEISLGQFMKAGSINVWNICPLFKGLGYASMVIVFYCNTYYIMVLAWGFYYLVKSFTTTLPWATCGHTWNTPDCVEIFRHEDCANASLANLTCDQLADRRSPVIEFWENKVLRLSTGLEVPGALNWEVTLCLLACWVLVYFCVWKGVKSTGKIVYFTATFPYVVLVVLLVRGVLLPGALDGIIYYLKPDWSKLGSPQVWIDAGTQIFFSYAIGLGALTALGSYNRFNNNCYKDAIILALINSGTSFFAGFVVFSILGFMATEQGVHISKVAESGPGLAFIAYPRAVTLMPVAPLWAALFFFMLLLLGLDSQFVGVEGFITGLLDLLPASYYFRFQREISVALCCALCFVIDLSMVTDGGMYVFQLFDYYSASGTTLLWQAFWECVVVAWVYGADRFMDDIACMIGYRPCPWMKWCWSFFTPLVCMGIFIFNIVYYEPLVYNNTYVYPWWGEAMGWAFALSSMLCVPLHLLGCLLRAKGTMAERWQHLTQPIWGLHHLEYRAQDADVRGLTTLTPVSESSKVVVVESVM
uniprot
proteins
function
FUNCTION: Creatine:sodium symporter which mediates the uptake of creatine (PubMed:12439290). Plays an important role in supplying creatine to the brain via the blood-brain barrier (PubMed:12439290). {ECO:0000269|PubMed:12439290}.
uniprot
proteins
mass_dalton
70571
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:12439290}.
uniprot
proteins
protein_family
SLC6A8 subfamily
uniprot
proteins
protein_family
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
uniprot
proteins
pubmed
12439290
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
635
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P48029}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:P48029}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 61..81; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 88..108; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 139..159; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 231..251; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 270..290; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 305..325; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 342..362; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 395..415; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 445..465; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 480..500; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 521..541; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 561..581; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins