Hmgcl
entrez
15356
canonical
uniprot
P38060
canonical
ensembl
ENSMUSG00000028672
resolver
ensp
ENSMUSP00000030432
resolver
ensp
ENSMUSP00000265111
resolver
ensp
ENSMUSP00000265114
resolver
ensp
ENSMUSP00000265121
resolver
ensp
ENSMUSP00000265130
resolver
enst
ENSMUST00000030432
resolver
genesymbol
Hmgcl
resolver
uniprot
Q8QZS6
resolver
uniprot_entry
HMGCL_MOUSE
resolver
uniprot_sec
Q8QZS6
resolver
amino_acid_sequence
MASVRKAFPRRLVGLTSLRAVSTSSMGTLPKQVKIVEVGPRDGLQNEKSIVPTPVKIRLIDMLSEAGLPVIEATSFVSPKWVPQMADHSDVLKGIQKFPGINYPVLTPNMKGFEEAVAAGAKEVSVFGAVSELFTRKNANCSIEESFQRFAGVMQAAQAASISVRGYVSCALGCPYEGKVSPAKVAEVAKKLYSMGCYEISLGDTIGVGTPGLMKDMLTAVMHEVPVTALAVHCHDTYGQALANTLVALQMGVSVVDSSVAGLGGCPYAKGASGNLATEDLVYMLNGLGIHTGVNLQKLLEAGDFICQALNRKTSSKVAQATCKL
uniprot
proteins
ec_number
4.1.3.4
uniprot
proteins
function
FUNCTION: Mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. {ECO:0000250|UniProtKB:P35914}.
uniprot
proteins
mass_dalton
34239
uniprot
proteins
pathway_participation
PATHWAY: Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.
uniprot
proteins
protein_family
HMG-CoA lyase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
7527399
uniprot
proteins
pubmed
8102917
uniprot
proteins
pubmed
8617516
uniprot
proteins
sequence_length
325
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:7527399}. Peroxisome {ECO:0000269|PubMed:7527399}. Note=Unprocessed form is peroxisomal.
uniprot
proteins