Atp4b
entrez
24217
canonical
uniprot
P18598
canonical
ensembl
ENSRNOG00000018543
resolver
ensembl
ENSRNOG00055014550
resolver
ensembl
ENSRNOG00060018512
resolver
ensembl
ENSRNOG00065009156
resolver
ensp
ENSRNOP00000025957
resolver
ensp
ENSRNOP00055020396
resolver
ensp
ENSRNOP00060025874
resolver
ensp
ENSRNOP00065010949
resolver
enst
ENSRNOT00000025958
resolver
enst
ENSRNOT00055024961
resolver
enst
ENSRNOT00060031847
resolver
enst
ENSRNOT00065014620
resolver
genesymbol
Atp4b
resolver
uniprot_entry
ATP4B_RAT
resolver
amino_acid_sequence
MAALQEKKSCSQRMAEFRQYCWNPDTGQMLGRTPARWVWISLYYAAFYVVMTGLFALCIYVLMQTIDPYTPDYQDQLKSPGVTLRPDVYGERGLQISYNISENSSWAGLTHTLHSFLAGYTPASQQDSINCSSEKYFFQETFSAPNHTKFSCKFTADMLQNCSGLVDPSFGFEEGKPCFIIKMNRIVKFLPSNNTAPRVDCTFQDDPQKPRKDIEPLQVQYYPPNGTFSLHYFPYYGKKAQPHYSNPLVAAKFLNVPKNTQVLIVCKIMADHVTFDNPHDPYEGKVEFKLTIQK
uniprot
proteins
function
FUNCTION: The beta subunit of the gastric H(+)/K(+) ATPase pump which transports H(+) ions in exchange for K(+) ions across the apical membrane of parietal cells. Plays a structural and regulatory role in the assembly and membrane targeting of a functionally active pump (By similarity). Within a transport cycle, the transfer of a H(+) ion across the membrane is coupled to ATP hydrolysis and is associated with a transient phosphorylation of the alpha subunit that shifts the pump conformation from inward-facing (E1) to outward-facing state (E2). Interacts with the phosphorylation domain of the alpha subunit and functions as a ratchet, stabilizing the lumenal-open E2 conformation and preventing the reverse reaction of the transport cycle (By similarity). {ECO:0000250|UniProtKB:P18597, ECO:0000250|UniProtKB:P19156}.
uniprot
proteins
mass_dalton
33689
uniprot
proteins
post_translational_modification
PTM: N-glycosylation is necessary for assembly and functional expression of the pump at the plasma membrane. {ECO:0000250|UniProtKB:P18597}.
uniprot
proteins
protein_family
X(+)/potassium ATPases subunit beta family
uniprot
proteins
pubmed
1657972
uniprot
proteins
pubmed
1663070
uniprot
proteins
pubmed
1978834
uniprot
proteins
pubmed
2165052
uniprot
proteins
sequence_length
294
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:P20648}; Single-pass type II membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:P18597}; Single-pass type II membrane protein {ECO:0000255}. Note=Localized in the apical canalicular membrane of parietal cells. {ECO:0000250|UniProtKB:P20648}.
uniprot
proteins
transmembrane_region
TRANSMEM 37..57; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins