Ccl5
entrez
20304
canonical
uniprot
P30882
canonical
ensembl
ENSMUSG00000035042
resolver
ensp
ENSMUSP00000039600
resolver
enst
ENSMUST00000035938
resolver
genesymbol
Ccl5
resolver
genesymbol_syn
Scya5
resolver
uniprot
Q5XZF2
resolver
uniprot_entry
CCL5_MOUSE
resolver
uniprot_entry
Q5XZF2_MOUSE
resolver
amino_acid_sequence
MKISAAALTIILTAAALCTPAPASPYGSDTTPCCFAYLSLALPRAHVKEYFYTSSKCSNLAVVFVTRRNRQVCANPEKKWVQEYINYLEMS
uniprot
proteins
function
FUNCTION: Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. {ECO:0000250|UniProtKB:P13501}.
uniprot
proteins
mass_dalton
10071
uniprot
proteins
protein_family
Intercrine beta (chemokine CC) family
uniprot
proteins
pubmed
10438970
uniprot
proteins
pubmed
1375672
uniprot
proteins
pubmed
1376260
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
7507961
uniprot
proteins
pubmed
7513046
uniprot
proteins
sequence_length
91
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins