Elob
entrez
81807
canonical
uniprot
P62870
canonical
ensembl
ENSRNOG00055027305
resolver
ensembl
ENSRNOG00060008875
resolver
ensembl
ENSRNOG00065009949
resolver
ensp
ENSRNOP00055038860
resolver
ensp
ENSRNOP00060011530
resolver
ensp
ENSRNOP00065012087
resolver
enst
ENSRNOT00055047271
resolver
enst
ENSRNOT00060014883
resolver
enst
ENSRNOT00065015988
resolver
genesymbol
Elob
resolver
genesymbol_syn
Tceb2
resolver
uniprot
Q63529
resolver
uniprot
Q80W20
resolver
uniprot_entry
ELOB_RAT
resolver
uniprot_sec
Q63529
resolver
uniprot_sec
Q80W20
resolver
amino_acid_sequence
MDVFLMIRRHKTTIFTDAKESSTVFELKRIVEGILKRPPEEQRLYKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFRADDTFEALRIEPFSSPPELPDVMKPQDSGGSANEQAVQ
uniprot
proteins
function
FUNCTION: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (By similarity). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity). {ECO:0000250|UniProtKB:P62869, ECO:0000250|UniProtKB:Q15370}.; FUNCTION: Core component of multiple cullin-2 and cullin-5-RING E3 ubiquitin-protein ligase complexes (ECS complexes), which mediate the ubiquitination of target proteins. By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes. Component the von Hippel-Lindau ubiquitination complex CBC(VHL). A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The ECS(ASB9) complex mediates ubiquitination and degradation of CKB. As part of a multisubunit ubiquitin ligase complex, polyubiquitinates monoubiquitinated POLR2A (By similarity). ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (By similarity). As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (By similarity). The ECS(ASB7) complex acts a negative regulator of H3K9me3 histone mark by mediating ubiquitination and degradation of SUV39H1 (By similarity). As part of the ECS(LRRC58) complex, mediates CDO1 ubiquitination and degradation, regulating cysteine catabolism (By similarity). {ECO:0000250|UniProtKB:P62869, ECO:0000250|UniProtKB:Q15370}.
uniprot
proteins
mass_dalton
13170
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q15370}.
uniprot
proteins
protein_family
Elongin B family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7638163
uniprot
proteins
pubmed
8244996
uniprot
proteins
sequence_length
118
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q15370}.
uniprot
proteins