Cltrn
entrez
57395
canonical
uniprot
Q9ESG3
canonical
ensembl
ENSRNOG00000003960
resolver
ensp
ENSRNOP00000005348
resolver
enst
ENSRNOT00000005348
resolver
genesymbol
Cltrn
resolver
genesymbol_syn
Nx17
resolver
genesymbol_syn
Tmem27
resolver
uniprot
Q6AYY2
resolver
uniprot_entry
CLTRN_RAT
resolver
uniprot_sec
Q6AYY2
resolver
amino_acid_sequence
MLWALFFLVTTIHAELCRPDAENAFKVRLSIKAALGDKAYVWDTDEEYLFRAMVAFSMRKVPNREGTEISHVLLCNVTQRVSFWFVVTDPLKNHTLPAAEVQSAIRMNRNRINSAFFLDDHTLEFLKIPSTLAPPMDPSVPVWIIVFGVIFCIVTVAIALLVLSGIRQRRRNKKGPPGVEDAEDKCENIITIENGIPCDPLDMKGGHINDGFLTEDERLTPL
uniprot
proteins
function
FUNCTION: Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their activity (By similarity). May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane (By similarity). Regulator of SNARE complex function (PubMed:16330323). Stimulator of beta cell replication (By similarity). {ECO:0000250|UniProtKB:Q9ESG4, ECO:0000269|PubMed:16330323}.
uniprot
proteins
mass_dalton
25051
uniprot
proteins
post_translational_modification
PTM: Glycosylated. Glycosylation is required for plasma membrane localization and for its cleavage by BACE2. {ECO:0000250|UniProtKB:Q9HBJ8}.; PTM: Proteolytically processed in pancreatic beta cells by BACE2 leading to the generation and extracellular release of soluble CLTRN, and a corresponding cell-associated C-terminal fragment which is later cleaved by gamma-secretase. This shedding process inactivates CLTRN (By similarity). Three cleavage sites have been identified for BACE2, two clustered sites after Phe-116 and Leu-118 and a more membrane proximal site at Phe-125; the preferred BACE2 cleavage site seems to be between Phe-125 and Leu-126, Phe-116 and Leu-118 act as alternative sites (By similarity). {ECO:0000250|UniProtKB:Q9ESG4, ECO:0000250|UniProtKB:Q9HBJ8}.
uniprot
proteins
protein_family
CLTRN family
uniprot
proteins
pubmed
11278314
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16330323
uniprot
proteins
sequence_length
222
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9ESG4}; Single-pass type I membrane protein {ECO:0000255}. Note=Localizes to the brush border membranes of cells in the proximal tubules of kidney. Colocalized with SLC6A19 in the early proximal S1 tubule. {ECO:0000250|UniProtKB:Q9ESG4}.
uniprot
proteins
transmembrane_region
TRANSMEM 142..162; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU01354
uniprot
proteins