DAZ4
entrez
57135
canonical
uniprot
Q86SG3
canonical
ensembl
ENSG00000188120
resolver
ensembl
ENSG00000205916
resolver
ensp
ENSP00000371751
resolver
ensp
ENSP00000389300
resolver
ensp
ENSP00000508087
resolver
enst
ENST00000682740
resolver
genesymbol
DAZ4
resolver
hgnc
HGNC:15966
resolver
uniprot
A0A804HKV4
resolver
uniprot
Q9NR88
resolver
uniprot
Q9NR89
resolver
uniprot_entry
A0A804HKV4_HUMAN
resolver
uniprot_entry
DAZ4_HUMAN
resolver
uniprot_sec
Q9NR88
resolver
uniprot_sec
Q9NR89
resolver
amino_acid_sequence
MSAANPETPNSTISREASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGSCFGRYGSVKEVKIITNRTGVSKGYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQKLCARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQSAANPETPNSTISREASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGSCFGRYGSVKEVKIITNRTGVSKGYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQKLCARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQAYSAYPHSPGQVITGCQLLVYNYQEYPTYPDSAFQVTTGYQLPVYNYQPFPAYPRSPFQVTAGYQLPVYNYQAFPAYPNSPFQVATGYQFPVYNYQPFPAYPSSPFQVTAGYQLPVYNYQAFPAYPNSPFQVATGYQFPVYNYQAFPAYPNSPVQVTTGYQLPVYNYQAFPAYPSSPFQVTTGYQLPVYNYQAFPAYPNSAVQVTTGYQFHVYNYQMPPQCPVGEQRRNLWTEAYKWWYLVCLIQRRD
uniprot
proteins
disease_involvement
DISEASE: Spermatogenic failure Y-linked 2 (SPGFY2) [MIM:415000]: A disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. {ECO:0000269|PubMed:11095434, ECO:0000269|PubMed:12801575}. Note=The disease may be caused by variants affecting the gene represented in this entry. AZFc deletions in the Yq11.23 region including the DAZ genes are the most common known genetic cause of human male infertility.
uniprot
proteins
function
FUNCTION: RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation.
uniprot
proteins
mass_dalton
64785
uniprot
proteins
protein_family
RRM DAZ family
uniprot
proteins
pubmed
10857750
uniprot
proteins
pubmed
10903443
uniprot
proteins
pubmed
10936047
uniprot
proteins
pubmed
11058556
uniprot
proteins
pubmed
11095434
uniprot
proteins
pubmed
11390979
uniprot
proteins
pubmed
12511597
uniprot
proteins
pubmed
12752250
uniprot
proteins
pubmed
12801575
uniprot
proteins
pubmed
12815422
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16275261
uniprot
proteins
pubmed
18385127
uniprot
proteins
pubmed
19223287
uniprot
proteins
pubmed
31429579
uniprot
proteins
sequence_length
579
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11058556, ECO:0000269|PubMed:31429579}. Nucleus {ECO:0000269|PubMed:11058556}. Note=Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis.
uniprot
proteins