Adal
entrez
75894
canonical
uniprot
Q80SY6
canonical
ensembl
ENSMUSG00000027259
resolver
ensp
ENSMUSP00000028702
resolver
ensp
ENSMUSP00000067133
resolver
ensp
ENSMUSP00000106290
resolver
ensp
ENSMUSP00000106293
resolver
ensp
ENSMUSP00000113052
resolver
enst
ENSMUST00000110665
resolver
genesymbol
Adal
resolver
genesymbol
Mapda
resolver
genesymbol_syn
Adal
resolver
uniprot
A2ARU3
resolver
uniprot
A2ARU4
resolver
uniprot
Q8BLN3
resolver
uniprot
Q8BX67
resolver
uniprot
Q9D4Q6
resolver
uniprot
Z4YL50
resolver
uniprot_entry
ADAL_MOUSE
resolver
uniprot_entry
Z4YL50_MOUSE
resolver
uniprot_sec
A2ARU3
resolver
uniprot_sec
A2ARU4
resolver
uniprot_sec
Q8BLN3
resolver
uniprot_sec
Q8BX67
resolver
uniprot_sec
Q9D4Q6
resolver
amino_acid_sequence
MEAGQQWPGKTDFYLQLPKVELHAHLNGSISSSTMKKLIAKKPHLNVHGHMTMIDKGKKRTLQECFQMFQVIHQLTTSAEDILMVTKDVIKEFADDGVKYLELRSTPREENATGMTRKTYVESVLEGIKQCKQENLDIDVRYLMAIDRRGGPTIARETVELAKEFFLSTENTVLGLDLSGDPTIGQANDFLEPLLEAKKAGLKLALHLAEIPNREKENQMLLSLLPDRIGHGTFLSASEAGALDQVDFVRQHQIPLELCLTSNIKSQTVPSYDQHHFGFWYSIAHPSVICTDDKGVFATYLSQEYQLAAETFNLTPFQVWDLSYESINYIFACDNTRSELRKRWTHLKQKVLNCNEVNYF
uniprot
proteins
ec_number
3.5.4.-
uniprot
proteins
function
FUNCTION: Deaminase involved in the detoxification of modified adenosines containing N(6)-methylated adenine (m6A) post-transcriptional modification (PubMed:40840445). Modified nucleosides are derived from the degradation of RNAs (mRNAs, rRNAs and tRNAs) and possess intrinsic cytotoxicity and must be cleared to prevent metabolic dysfunction (PubMed:40840445). Acts downstream of ADK and catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotides N(6)-methyl-AMP (m6AMP), N(6),N(6)-dimethyl-AMP (m6,6AMP) and N(6)-isopentenyl-AMP (i6AMP) to produce inositol monophosphate (IMP) (PubMed:40840445). Catalyzes the removal of different alkyl groups not only from N6-substituted purine or 2-aminopurine nucleoside monophosphates but also from O6-substituted compounds in vitro (By similarity). {ECO:0000250|UniProtKB:Q6DHV7, ECO:0000269|PubMed:40840445}.
uniprot
proteins
mass_dalton
41001
uniprot
proteins
protein_family
Adenosine and AMP deaminases family
uniprot
proteins
protein_family
Metallo-dependent hydrolases superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
40840445
uniprot
proteins
sequence_length
360
uniprot
proteins