Htr5b
entrez
79247
canonical
uniprot
P35365
canonical
ensembl
ENSRNOG00000002549
resolver
ensembl
ENSRNOG00055013150
resolver
ensembl
ENSRNOG00060005940
resolver
ensembl
ENSRNOG00065009722
resolver
ensp
ENSRNOP00000003441
resolver
ensp
ENSRNOP00055018298
resolver
ensp
ENSRNOP00060007366
resolver
ensp
ENSRNOP00065011789
resolver
enst
ENSRNOT00000003441
resolver
enst
ENSRNOT00055022531
resolver
enst
ENSRNOT00060009826
resolver
enst
ENSRNOT00065015620
resolver
genesymbol
Htr5b
resolver
genesymbol_syn
5ht5b
resolver
uniprot_entry
5HT5B_RAT
resolver
amino_acid_sequence
MEVSNLSGATPGIAFPPGPESCSDSPSSGRSMGSTPGGLILSGREPPFSAFTVLVVTLLVLLIAATFLWNLLVLVTILRVRAFHRVPHNLVASTAVSDVLVAALVMPLSLVSELSAGRRWQLGRSLCHVWISFDVLCCTASIWNVAAIALDRYWTITRHLQYTLRTRRRASALMIAITWALSALIALAPLLFGWGEAYDARLQRCQVSQEPSYAVFSTCGAFYVPLAVVLFVYWKIYKAAKFRFGRRRRAVVPLPATTQAKEAPQESETVFTARCRATVAFQTSGDSWREQKEKRAAMMVGILIGVFVLCWIPFFLTELVSPLCACSLPPIWKSIFLWLGYSNSFFNPLIYTAFNKNYNNAFKSLFTKQR
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:7682702). Also functions as a receptor for ergot alkaloid derivatives and other psychoactive substances (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). Htr5b is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (By similarity). {ECO:0000250|UniProtKB:P47898, ECO:0000269|PubMed:7682702}.
uniprot
proteins
mass_dalton
41122
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
7682702
uniprot
proteins
pubmed
8224165
uniprot
proteins
sequence_length
370
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P47898}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 49..75; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P47898"; TRANSMEM 89..115; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P47898"; TRANSMEM 128..150; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P47898"; TRANSMEM 169..189; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P47898"; TRANSMEM 212..233; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P47898"; TRANSMEM 301..325; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P47898"; TRANSMEM 328..352; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P47898
uniprot
proteins