Map2k7
entrez
363855
canonical
uniprot
Q4KSH7
canonical
ensembl
ENSRNOG00000001047
resolver
ensembl
ENSRNOG00055004114
resolver
ensembl
ENSRNOG00060002502
resolver
ensembl
ENSRNOG00065005808
resolver
ensp
ENSRNOP00000058535
resolver
ensp
ENSRNOP00000072160
resolver
ensp
ENSRNOP00000086269
resolver
ensp
ENSRNOP00055005034
resolver
ensp
ENSRNOP00060002839
resolver
ensp
ENSRNOP00065006161
resolver
enst
ENSRNOT00000061821
resolver
enst
ENSRNOT00000084460
resolver
enst
ENSRNOT00000104881
resolver
enst
ENSRNOT00055006583
resolver
enst
ENSRNOT00060004015
resolver
enst
ENSRNOT00065008700
resolver
genesymbol
Map2k7
resolver
uniprot
A0A8L2UMW0
resolver
uniprot
A0ACM8QK61
resolver
uniprot
A6KQ64
resolver
uniprot
D3XAM6
resolver
uniprot_entry
A0A8L2UMW0_RAT
resolver
uniprot_entry
A0ACM8QK61_RAT
resolver
uniprot_entry
A6KQ64_RAT
resolver
uniprot_entry
MP2K7_RAT
resolver
uniprot_sec
D3XAM6
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation by specific MAP kinase kinase kinases such as MAP3K1/MEKK1, MAP3K3/MEKK3, MAP3K11/MLK3 and MAP3K12/DLK.
uniprot
proteins
amino_acid_sequence
MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSESSPQHPTPPSRPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHIIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKHYETLEVDVASWFKDVMAKTESPRTSGVLSQHHLPFFR
uniprot
proteins
ec_number
2.7.12.2
uniprot
proteins
function
FUNCTION: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (By similarity). {ECO:0000250|UniProtKB:Q8CE90, ECO:0000269|PubMed:10051439}.
uniprot
proteins
mass_dalton
47536
uniprot
proteins
post_translational_modification
PTM: Activated by phosphorylation on Ser-271 and Thr-275 by MAP kinase kinase kinases (MAP3Ks). {ECO:0000269|PubMed:14575811}.
uniprot
proteins
protein_family
MAP kinase kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
pubmed
10051439
uniprot
proteins
pubmed
14575811
uniprot
proteins
pubmed
17496909
uniprot
proteins
pubmed
20801953
uniprot
proteins
pubmed
21333379
uniprot
proteins
sequence_length
419
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8CE90}. Cytoplasm {ECO:0000250|UniProtKB:Q8CE90}.
uniprot
proteins