NMT1
entrez
4836
canonical
uniprot
P30419
canonical
ensembl
ENSG00000136448
resolver
ensp
ENSP00000258960
resolver
genesymbol
NMT1
resolver
genesymbol_syn
NMT
resolver
hgnc
HGNC:7857
resolver
uniprot
A8K7C1
resolver
uniprot
Q9UE09
resolver
uniprot_entry
NMT1_HUMAN
resolver
uniprot_sec
A8K7C1
resolver
uniprot_sec
Q9UE09
resolver
amino_acid_sequence
MADESETAVKPPAPPLPQMMEGNGNGHEHCSDCENEEDNSYNRGGLSPANDTGAKKKKKKQKKKKEKGSETDSAQDQPVKMNSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLLTRYLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVLQ
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
ec_number
2.3.1.97
uniprot
proteins
function
FUNCTION: Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins (PubMed:22865860, PubMed:25255805, PubMed:32686708, PubMed:34999170, PubMed:9353336, PubMed:9506952). Also able to mediate N-terminal lysine myristoylation of proteins: catalyzes myristoylation of ARF6 on both 'Gly-2' and 'Lys-3' (PubMed:32103017, PubMed:32111831). Lysine myristoylation is required to maintain ARF6 on membranes during the GTPase cycle (PubMed:32103017). {ECO:0000269|PubMed:22865860, ECO:0000269|PubMed:25255805, ECO:0000269|PubMed:32103017, ECO:0000269|PubMed:32111831, ECO:0000269|PubMed:32686708, ECO:0000269|PubMed:34999170, ECO:0000269|PubMed:9353336, ECO:0000269|PubMed:9506952}.
uniprot
proteins
mass_dalton
56806
uniprot
proteins
mutagenesis
MUTAGEN 180; /note="Y->P: Abolished glycine- and lysine-myristoyltransferase activities."; /evidence="ECO:0000269|PubMed:32111831"; MUTAGEN 181; /note="V->L: Reduced glycine N-myristoyltransferase activity."; /evidence="ECO:0000269|PubMed:32111831"; MUTAGEN 192; /note="Y->A: Reduced glycine N-myristoyltransferase activity."; /evidence="ECO:0000269|PubMed:32111831"; MUTAGEN 492; /note="G->D,K: Reduced activity."; /evidence="ECO:0000269|PubMed:1570339
uniprot
proteins
protein_family
NMT family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1570339
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
22865860
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25255805
uniprot
proteins
pubmed
32103017
uniprot
proteins
pubmed
32111831
uniprot
proteins
pubmed
32686708
uniprot
proteins
pubmed
34999170
uniprot
proteins
pubmed
9353336
uniprot
proteins
pubmed
9506952
uniprot
proteins
pubmed
9677304
uniprot
proteins
sequence_length
496
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9353336, ECO:0000269|PubMed:9506952}. Cytoplasm, cytosol {ECO:0000269|PubMed:9353336}. Membrane {ECO:0000269|PubMed:9506952}; Peripheral membrane protein {ECO:0000269|PubMed:9506952}. Note=Copurifies with ribosomes. {ECO:0000269|PubMed:9353336}.
uniprot
proteins