Pdp2
entrez
382051
canonical
uniprot
Q504M2
canonical
ensembl
ENSMUSG00000048371
resolver
ensp
ENSMUSP00000092821
resolver
ensp
ENSMUSP00000166759
resolver
enst
ENSMUST00000059588
resolver
genesymbol
Pdp2
resolver
uniprot_entry
PDP2_MOUSE
resolver
amino_acid_sequence
MSSTVSYWIFNSARNRIALLRGGRRLYSRAATSRNLLKWRPFSPALASSALKCGSPPGGFALRKAYRHTSTEEEDFHLQLSPEQVSDLLRAGESSHKVLDFNNGVPNSVLRFESNQLAANSPVEDRQGVATCVQTNGMMFGIFDGHGGHACAQAVSERLFYYMAVSLMSHQTLEQMEEATENMKPLLPILRWLKHPGDSIYKDVTSVHLDHLRVYWQELLDLHMEMGLSIEEALMYSFQRLDSDISLEIQAPLEDEVTRNLSLQVAFSGATACMAHVNGVHLHVANAGDCRAILGVQEENGAWSCLPLTCDHNAWNEAELSRLKREHPESEDRTLIIDDRLLGVLMPCRAFGDVQLKWSKELQRNVLARGFDTEALNIYQFTPPHYYTPPYLTAKPEVTYHRLRRQDKFLVLASDGLWDMLGNEDVVRLVVGHLSKVGRHKPDLDQRPANLGLMQSLLLQRKASGLHAADQNTATHLIRHAIGSNEYGEMEPERLAAMLTLPEDVARMYRDDITVMVVFFNSDSIDTYCKEG
uniprot
proteins
ec_number
3.1.3.43
uniprot
proteins
function
FUNCTION: Mitochondrial enzyme that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex (PDC), thereby stimulating the conversion of pyruvate into acetyl-CoA (By similarity). Acts as a crucial regulator of T cell metabolism and function, with a particular focus on T-helper Th17 (PubMed:30150402). {ECO:0000250|UniProtKB:O88484, ECO:0000269|PubMed:30150402}.
uniprot
proteins
mass_dalton
59947
uniprot
proteins
protein_family
PP2C family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30150402
uniprot
proteins
sequence_length
532
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:O88484}.
uniprot
proteins