Calm1
entrez
12313
canonical
uniprot
P0DP26
canonical
ensembl
ENSMUSG00000001175
resolver
ensembl
ENSMUSG00000019370
resolver
ensembl
ENSMUSG00000036438
resolver
ensp
ENSMUSP00000019514
resolver
ensp
ENSMUSP00000048857
resolver
ensp
ENSMUSP00000105709
resolver
enst
ENSMUST00000019514
resolver
enst
ENSMUST00000040440
resolver
enst
ENSMUST00000110082
resolver
genesymbol
Calm1
resolver
genesymbol_syn
Calm
resolver
genesymbol_syn
Cam
resolver
genesymbol_syn
Cam1
resolver
uniprot
P02593
resolver
uniprot
P62204
resolver
uniprot
P70667
resolver
uniprot
P99014
resolver
uniprot
Q3TEH7
resolver
uniprot
Q3THK5
resolver
uniprot
Q3U6Z5
resolver
uniprot
Q3U7C7
resolver
uniprot
Q3UKW2
resolver
uniprot
Q498A3
resolver
uniprot
Q61379
resolver
uniprot
Q61380
resolver
uniprot
Q8BNC9
resolver
uniprot
Q91VQ9
resolver
uniprot
Q9D6G4
resolver
uniprot_entry
CALM1_MOUSE
resolver
uniprot_entry
Q3UKW2_MOUSE
resolver
uniprot_sec
P02593
resolver
uniprot_sec
P62204
resolver
uniprot_sec
P70667
resolver
uniprot_sec
P99014
resolver
uniprot_sec
Q3TEH7
resolver
uniprot_sec
Q3THK5
resolver
uniprot_sec
Q3U6Z5
resolver
uniprot_sec
Q3U7C7
resolver
uniprot_sec
Q498A3
resolver
uniprot_sec
Q61379
resolver
uniprot_sec
Q61380
resolver
uniprot_sec
Q8BNC9
resolver
uniprot_sec
Q91VQ9
resolver
uniprot_sec
Q9D6G4
resolver
amino_acid_sequence
MADQLTEEQIAEFKEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGNGTIDFPEFLTMMARKMKDTDSEEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADIDGDGQVNYEEFVQMMTAK
uniprot
proteins
function
FUNCTION: Calmodulin acts as part of a calcium signal transduction pathway by mediating the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding (By similarity). Calcium-binding is required for the activation of calmodulin (By similarity). Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases, such as myosin light-chain kinases and calmodulin-dependent protein kinase type II (CaMK2), and phosphatases (By similarity). Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis (By similarity). Is a regulator of voltage-dependent L-type calcium channels (By similarity). Mediates calcium-dependent inactivation of CACNA1C (By similarity). Positively regulates calcium-activated potassium channel activity of KCNN2 (By similarity). Forms a potassium channel complex with KCNQ1 and regulates electrophysiological activity of the channel via calcium-binding (By similarity). Acts as a sensor to modulate the endoplasmic reticulum contacts with other organelles mediated by VMP1:ATP2A2 (By similarity). Component of the silencing factor of the integrated stress response (SIFI) complex, a multiprotein complex required to turn off the mitochondrial stress response after a specific stress event has been resolved (By similarity). {ECO:0000250|UniProtKB:P0DP23}.
uniprot
proteins
mass_dalton
16838
uniprot
proteins
mutagenesis
MUTAGEN 115; /note="E->A: Decreases interaction with SCN8A in the absence of calcium."; /evidence="ECO:0000269|PubMed:23942337"; MUTAGEN 121; /note="E->A: Decreases interaction with SCN8A in the absence of calcium."; /evidence="ECO:0000269|PubMed:23942337"; MUTAGEN 124; /note="E->A: Decreases interaction with SCN8A in the absence of calcium."; /evidence="ECO:0000269|PubMed:23942337"; MUTAGEN 128; /note="E->A: Decreases interaction with SCN8A in the absence of calcium."; /evidence="ECO:0000269|PubMed:23942337
uniprot
proteins
post_translational_modification
PTM: Ubiquitination results in a strongly decreased activity. {ECO:0000250}.; PTM: Phosphorylation results in a decreased activity. {ECO:0000250|UniProtKB:P0DP29}.
uniprot
proteins
protein_family
Calmodulin family
uniprot
proteins
pubmed
10620513
uniprot
proteins
pubmed
12106288
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16569770
uniprot
proteins
pubmed
17151196
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
18650434
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
23942337
uniprot
proteins
pubmed
24569478
uniprot
proteins
pubmed
25380116
uniprot
proteins
pubmed
29025071
uniprot
proteins
pubmed
31088288
uniprot
proteins
pubmed
3384819
uniprot
proteins
pubmed
36417862
uniprot
proteins
sequence_length
149
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:P0DP23}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:P0DP23}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P0DP23}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:29025071}. Note=Distributed throughout the cell during interphase, but during mitosis becomes dramatically localized to the spindle poles and the spindle microtubules. {ECO:0000250|UniProtKB:P0DP23}.
uniprot
proteins