CTSS
entrez
1520
canonical
uniprot
P25774
canonical
ensembl
ENSG00000163131
resolver
ensp
ENSP00000357981
resolver
ensp
ENSP00000506001
resolver
genesymbol
CTSS
resolver
hgnc
HGNC:2545
resolver
uniprot
B4DWC9
resolver
uniprot
D3DV05
resolver
uniprot
Q5T5I0
resolver
uniprot
Q6FHS5
resolver
uniprot
Q9BUG3
resolver
uniprot_entry
CATS_HUMAN
resolver
uniprot_sec
B4DWC9
resolver
uniprot_sec
D3DV05
resolver
uniprot_sec
Q5T5I0
resolver
uniprot_sec
Q6FHS5
resolver
uniprot_sec
Q9BUG3
resolver
amino_acid_sequence
MKRLVCVLLVCSSAVAQLHKDPTLDHHWHLWKKTYGKQYKEKNEEAVRRLIWEKNLKFVMLHNLEHSMGMHSYDLGMNHLGDMTSEEVMSLMSSLRVPSQWQRNITYKSNPNRILPDSVDWREKGCVTEVKYQGSCGACWAFSAVGALEAQLKLKTGKLVSLSAQNLVDCSTEKYGNKGCNGGFMTTAFQYIIDNKGIDSDASYPYKAMDQKCQYDSKYRAATCSKYTELPYGREDVLKEAVANKGPVSVGVDARHPSFFLYRSGVYYEPSCTQNVNHGVLVVGYGDLNGKEYWLVKNSWGHNFGEEGYIRMARNKGNHCGIASFPSYPEI
uniprot
proteins
ec_number
3.4.22.27
uniprot
proteins
function
FUNCTION: Thiol protease (PubMed:30612035). Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation (PubMed:30612035). The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L (PubMed:30612035). Elicits itch by mediating cleavage and activation of MRGPRX1 (By similarity). {ECO:0000250|UniProtKB:O70370, ECO:0000269|PubMed:30612035}.
uniprot
proteins
mass_dalton
37496
uniprot
proteins
mutagenesis
MUTAGEN 104; /note="N->Q: Abolishes glycosylation."; /evidence="ECO:0000269|PubMed:9524075
uniprot
proteins
protein_family
Peptidase C1 family
uniprot
proteins
pubmed
11856830
uniprot
proteins
pubmed
1373132
uniprot
proteins
pubmed
1377692
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17469812
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
30612035
uniprot
proteins
pubmed
8157683
uniprot
proteins
pubmed
9524075
uniprot
proteins
pubmed
9876921
uniprot
proteins
sequence_length
331
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:1377692}. Secreted {ECO:0000269|PubMed:9524075}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:30612035}.
uniprot
proteins