Rab29
entrez
171122
canonical
uniprot
Q63481
canonical
ensembl
ENSRNOG00000049641
resolver
ensembl
ENSRNOG00055020918
resolver
ensembl
ENSRNOG00060015436
resolver
ensembl
ENSRNOG00065020015
resolver
ensp
ENSRNOP00000067600
resolver
ensp
ENSRNOP00055028959
resolver
ensp
ENSRNOP00060021145
resolver
ensp
ENSRNOP00065027022
resolver
enst
ENSRNOT00000073669
resolver
enst
ENSRNOT00055035701
resolver
enst
ENSRNOT00060026446
resolver
enst
ENSRNOT00065033747
resolver
genesymbol
Rab29
resolver
genesymbol_syn
Rab7l1
resolver
uniprot_entry
RAB7L_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MGSRDHLFKVLVVGDAAVGKTSLVQRYSQDSFSKHYKSTVGVDFALKVLQWSDSEMVRLQLWDIAGQERFTSMTRLYYRDASACVIMFDVTNATTFSNSQRWKQDLDSKLTLPSGEPVPCLLLANKSDLSPWAVSRDQIDRFSKENGFTGWTETSVKENKNINEAMRVLVEKMMNNSREDIMSSSTQGNYINLQTKPSPGWTCC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:23395371). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB29 is essential for maintaining the integrity of endosome-trans-Golgi network structure (PubMed:23395371). Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:23395371). Recruits LRRK2 to the Golgi apparatus and stimulates LRRK2 kinase activity (By similarity). Stimulates phosphorylation of RAB10 'Thr-73' by LRRK2 (By similarity). Also regulates neuronal process morphology in the intact central nervous system (CNS) (PubMed:23395371). {ECO:0000250|UniProtKB:O14966, ECO:0000250|UniProtKB:Q13637, ECO:0000269|PubMed:23395371}.
uniprot
proteins
mass_dalton
23117
uniprot
proteins
mutagenesis
MUTAGEN 21; /note="T->N: Abolishes localization at trans-Golgi network (TGN) and affects the integrity of the TGN. Inhibits retrograde trafficking of M6PR-associated vesicles."; /evidence="ECO:0000269|PubMed:23395371"; MUTAGEN 67; /note="Q->L: Localizes predominantly in the cytosol."; /evidence="ECO:0000269|PubMed:23395371
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
23395371
uniprot
proteins
pubmed
9177482
uniprot
proteins
sequence_length
204
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm {ECO:0000250|UniProtKB:O14966}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O14966}. Golgi apparatus {ECO:0000269|PubMed:23395371}. Golgi apparatus membrane {ECO:0000250|UniProtKB:O14966}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:O14966}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23395371}. Note=Colocalizes with GM130 at the Golgi apparatus (By similarity). Colocalizes with dynamic tubules emerging from and retracting to the Golgi apparatus (By similarity). Colocalizes with TGN46 at the trans-Golgi network (TGN) (By similarity). Colocalized with LRRK2 along tubular structures emerging from Golgi apparatus (PubMed:23395371). {ECO:0000250|UniProtKB:O14966, ECO:0000269|PubMed:23395371}.
uniprot
proteins