Fscn1
entrez
14086
canonical
uniprot
Q61553
canonical
ensembl
ENSMUSG00000029581
resolver
ensp
ENSMUSP00000031565
resolver
enst
ENSMUST00000031565
resolver
genesymbol
Fscn1
resolver
genesymbol_syn
Fan1
resolver
genesymbol_syn
Snl
resolver
uniprot
O09099
resolver
uniprot
O09156
resolver
uniprot
Q05DK3
resolver
uniprot
Q7TN32
resolver
uniprot
Q80V75
resolver
uniprot_entry
FSCN1_MOUSE
resolver
uniprot_sec
O09099
resolver
uniprot_sec
O09156
resolver
uniprot_sec
Q05DK3
resolver
uniprot_sec
Q7TN32
resolver
uniprot_sec
Q80V75
resolver
amino_acid_sequence
MTANGTAEAVQIQFGLISCGNKYLTAEAFGFKVNASASSLKKKQIWTLEQPPDEAGSAAVCLRSHLGRYLAADKDGNVTCEREVPDGDCRFLVVAHDDGRWSLQSEAHRRYFGGTEDRLSCFAQSVSPAEKWSVHIAMHPQVNIYSVTRKRYAHLSARPADEIAVDRDVPWGVDSLITLAFQDQRYSVQTSDHRFLRHDGRLVARPEPATGFTLEFRSGKVAFRDCEGRYLAPSGPSGTLKAGKATKVGKDELFALEQSCAQVVLQAANERNVSTRQGMDLSANQDEETDQETFQLEIDRDTRKCAFRTHTGKYWTLTATGGVQSTASTKNASCYFDIEWCDRRITLRASNGKFVTAKKNGQLAASVETAGDSELFLMKLINRPIIVFRGEHGFIGCRKVTGTLDANRSSYDVFQLEFNDGAYNIKDSTGKYWTVGSDSSVTSSSDTPVDFFLEFCDYNKVALKVGGRYLKGDHAGVLKACAETIDPASLWEY
uniprot
proteins
function
FUNCTION: Actin-binding protein that contains 2 major actin binding sites (By similarity). Organizes filamentous actin into parallel bundles (PubMed:7738015). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers (By similarity). Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration (PubMed:21685497). Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF (By similarity). {ECO:0000250|UniProtKB:Q16658, ECO:0000269|PubMed:21685497, ECO:0000269|PubMed:7738015}.
uniprot
proteins
mass_dalton
54508
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-39 inhibits actin-binding. Phosphorylation is required for the reorganization of the actin cytoskeleton in response to NGF. {ECO:0000250|UniProtKB:Q16658}.
uniprot
proteins
protein_family
Fascin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20393565
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21685497
uniprot
proteins
pubmed
21706053
uniprot
proteins
pubmed
22155786
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
24720729
uniprot
proteins
pubmed
7738015
uniprot
proteins
pubmed
8794867
uniprot
proteins
sequence_length
493
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q16658}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q16658}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q16658}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:Q16658}. Cell projection, growth cone {ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:24720729}. Cell projection, filopodium {ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:24720729}. Cell projection, invadopodium {ECO:0000269|PubMed:24720729}. Cell projection, microvillus {ECO:0000250|UniProtKB:Q16658}. Cell junction {ECO:0000250|UniProtKB:Q16658}. Note=Colocalized with RUFY3 and F-actin at filipodia of the axonal growth cone (PubMed:24720729). Colocalized with DBN1 and F-actin at the transitional domain of the axonal growth cone (PubMed:24720729). {ECO:0000250|UniProtKB:Q16658, ECO:0000269|PubMed:24720729}.
uniprot
proteins