NCOA6
entrez
23054
canonical
uniprot
Q14686
canonical
ensembl
ENSG00000198646
resolver
ensp
ENSP00000351894
resolver
ensp
ENSP00000363929
resolver
ensp
ENSP00000481177
resolver
ensp
ENSP00000481935
resolver
ensp
ENSP00000557814
resolver
ensp
ENSP00000557815
resolver
ensp
ENSP00000557816
resolver
ensp
ENSP00000601710
resolver
ensp
ENSP00000601711
resolver
ensp
ENSP00000601712
resolver
ensp
ENSP00000601713
resolver
ensp
ENSP00000601714
resolver
ensp
ENSP00000601715
resolver
enst
ENST00000359003
resolver
enst
ENST00000374796
resolver
enst
ENST00000612493
resolver
enst
ENST00000887756
resolver
enst
ENST00000887757
resolver
enst
ENST00000931654
resolver
genesymbol
NCOA6
resolver
genesymbol_syn
AIB3
resolver
genesymbol_syn
KIAA0181
resolver
genesymbol_syn
RAP250
resolver
genesymbol_syn
TRBP
resolver
hgnc
HGNC:15936
resolver
uniprot
A0A087WXP1
resolver
uniprot
A6NLF1
resolver
uniprot
B2RMN5
resolver
uniprot
E1P5P7
resolver
uniprot
F6M2K2
resolver
uniprot
F6M2K3
resolver
uniprot
Q9NTZ9
resolver
uniprot
Q9UH74
resolver
uniprot
Q9UK86
resolver
uniprot_entry
A0A087WXP1_HUMAN
resolver
uniprot_entry
F6M2K2_HUMAN
resolver
uniprot_entry
F6M2K3_HUMAN
resolver
uniprot_entry
NCOA6_HUMAN
resolver
uniprot_sec
A6NLF1
resolver
uniprot_sec
B2RMN5
resolver
uniprot_sec
E1P5P7
resolver
uniprot_sec
Q9NTZ9
resolver
uniprot_sec
Q9UH74
resolver
uniprot_sec
Q9UK86
resolver
amino_acid_sequence
MVLDDLPNLEDIYTSLCSSTMEDSEMDFDSGLEDDDTKSDSILEDSTIFVAFKGNIDDKDFKWKLDAILKNVPNLLHMESSKLKVQKVEPWNSVRVTFNIPREAAERLRILAQSNNQQLRDLGILSVQIEGEGAINLALAQNRSQDVRMNGPMGAGNSVRMEAGFPMASGPGIIRMNNPATVMIPPGGNVSSSMMAPGPNPELQPRTPRPASQSDAMDPLLSGLHIQQQSHPSGSLAPPHHPMQPVSVNRQMNPANFPQLQQQQQQQQQQQQQQQQQQQQQQQQQLQARPPQQHQQQQPQGIRPQFTAPTQVPVPPGWNQLPSGALQPPPAQGSLGTMTANQGWKKAPLPGPMQQQLQARPSLATVQTPSHPPPPYPFGSQQASQAHTNFPQMSNPGQFTAPQMKSLQGGPSRVPTPLQQPHLTNKSPASSPSSFQQGSPASSPTVNQTQQQMGPRPPQNNPLPQGFQQPVSSPGRNPMVQQGNVPPNFMVMQQQPPNQGPQSLHPGLGGMPKRLPPGFSAGQANPNFMQGQVPSTTATTPGNSGAPQLQANQNVQHAGGQGAGPPQNQMQVSHGPPNMMQPSLMGIHGNMNNQQAGTSGVPQVNLSNMQGQPQQGPPSQLMGMHQQIVPSQGQMVQQQGTLNPQNPMILSRAQLMPQGQMMVNPPSQNLGPSPQRMTPPKQMLSQQGPQMMAPHNQMMGPQGQVLLQQNPMIEQIMTNQMQGNKQQFNTQNQSNVMPGPAQIMRGPTPNMQGNMVQFTGQMSGQMLPQQGPVNNSPSQVMGIQGQVLRPPGPSPHMAQQHGDPATTANNDVSLSQMMPDVSIQQTNMVPPHVQAMQGNSASGNHFSGHGMSFNAPFSGAPNGNQMSCGQNPGFPVNKDVTLTSPLLVNLLQSDISAGHFGVNNKQNNTNANKPKKKKPPRKKKNSQQDLNTPDTRPAGLEEADQPPLPGEQGINLDNSGPKLPEFSNRPPGYPSQPVEQRPLQQMPPQLMQHVAPPPQPPQQQPQPQLPQQQQPPPPSQPQSQQQQQQQQQMMMMLMMQQDPKSVRLPVSQNVHPPRGPLNPDSQRMPMQQSGSVPVMVSLQGPASVPPSPDKQRMPMPVNTPLGSNSRKMVYQESPQNPSSSPLAEMASLPEASGSEAPSVPGGPNNMPSHVVLPQNQLMMTGPKPGPSPLSATQGATPQQPPVNSLPSSHGHHFPNVAAPTQTSRPKTPNRASPRPYYPQTPNNRPPSTEPSEISLSPERLNASIAGLFPPQINIPLPPRPNLNRGFDQQGLNPTTLKAIGQAPSNLTMNPSNFATPQTHKLDSVVVNSGKQSNSGATKRASPSNSRRSSPGSSRKTTPSPGRQNSKAPKLTLASQTNAALLQNVELPRNVLVSPTPLANPPVPGSFPNNSGLNPQNSTVSVAAVGGVVEDNKESLNVPQDSDCQNSQSRKEQVNIELKAVPAQEVKMVVPEDQSKKDGQPSDPNKLPSVEENKNLVSPAMREAPTSLSQLLDNSGAPNVTIKPPGLTDLEVTPPVVSGEDLKKASVIPTLQDLSSSKEPSNSLNLPHSNELCSSLVHPELSEVSSNVAPSIPPVMSRPVSSSSISTPLPPNQITVFVTSNPITTSANTSAALPTHLQSALMSTVVTMPNAGSKVMVSEGQSAAQSNARPQFITPVFINSSSIIQVMKGSQPSTIPAAPLTTNSGLMPPSVAVVGPLHIPQNIKFSSAPVPPNALSSSPAPNIQTGRPLVLSSRATPVQLPSPPCTSSPVVPSHPPVQQVKELNPDEASPQVNTSADQNTLPSSQSTTMVSPLLTNSPGSSGNRRSPVSSSKGKGKVDKIGQILLTKACKKVTGSLEKGEEQYGADGETEGQGLDTTAPGLMGTEQLSTELDSKTPTPPAPTLLKMTSSPVGPGTASAGPSLPGGALPTSVRSIVTTLVPSELISAVPTTKSNHGGIASESLAGGLVEEKVGSHPELLPSIAPSQNLVSKETSTTALQASVARPELEVNAAIVSGQSSEPKEIVEKSKIPGRRNSRTEEPTVASESVENGHRKRSSRPASASSSTKDITSAVQSKRRKSK
uniprot
proteins
function
FUNCTION: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.
uniprot
proteins
mass_dalton
219145
uniprot
proteins
mutagenesis
MUTAGEN 883..894; /note="TSPLLVNLLQSD->ENPLLVNLLQFI: Reduced binding to THRB, RXRA, ESR2 and ESR1."; /evidence="ECO:0000269|PubMed:11773444"; MUTAGEN 883..894; /note="TSPLLVNLLQSD->NLPLLVNLLQHT: Reduced binding to THRB, RXRA, ESR2 and ESR1."; /evidence="ECO:0000269|PubMed:11773444"; MUTAGEN 883..894; /note="TSPLLVNLLQSD->VNPLLVNLLQFI: Reduced binding to THRB, RXRA, ESR2 and ESR1."; /evidence="ECO:0000269|PubMed:11773444"; MUTAGEN 883..884; /note="TS->SY: Strong increase in binding to THRB, RXRA and ESR2, but dramatic decrease in binding to ESR1."; MUTAGEN 884..894; /note="SPLLVNLLQSD->NPLLVNLLQLL: Reduced binding to THRB, RXRA, ESR2 and ESR1.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PRKDC.; PTM: Phosphorylation on Ser-884 leads to a strong decrease in binding to ESR1 and ESR2. {ECO:0000269|PubMed:10823961, ECO:0000269|PubMed:11773444}.
uniprot
proteins
pubmed
10567404
uniprot
proteins
pubmed
10681503
uniprot
proteins
pubmed
10823961
uniprot
proteins
pubmed
10866662
uniprot
proteins
pubmed
11443112
uniprot
proteins
pubmed
11517327
uniprot
proteins
pubmed
11773444
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12039952
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
12215545
uniprot
proteins
pubmed
12482968
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17021013
uniprot
proteins
pubmed
17500065
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8724849
uniprot
proteins
sequence_length
2063
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins