ATP1B1
entrez
481
canonical
uniprot
P05026
canonical
ensembl
ENSG00000143153
resolver
ensp
ENSP00000356789
resolver
genesymbol
ATP1B1
resolver
genesymbol_syn
ATP1B
resolver
hgnc
HGNC:804
resolver
uniprot
A3KLL5
resolver
uniprot
Q5TGZ3
resolver
uniprot_entry
A3KLL5_HUMAN
resolver
uniprot_entry
AT1B1_HUMAN
resolver
uniprot_sec
Q5TGZ3
resolver
amino_acid_sequence
MARGKAKEEGSWKKFIWNSEKKEFLGRTGGSWFKILLFYVIFYGCLAGIFIGTIQVMLLTISEFKPTYQDRVAPPGLTQIPQIQKTEISFRPNDPKSYEAYVLNIVRFLEKYKDSAQRDDMIFEDCGDVPSEPKERGDFNHERGERKVCRFKLEWLGNCSGLNDETYGYKEGKPCIIIKLNRVLGFKPKPPKNESLETYPVMKYNPNVLPVQCTGKRDEDKDKVGNVEYFGLGNSPGFPLQYYPYYGKLLQPKYLQPLLAVQFTNLTMDTEIRIECKAYGENIGYSEKDRFQGRFDVKIEVKS
uniprot
proteins
function
FUNCTION: Non-catalytic subunit of the Na(+)/K(+)-ATPase pump that hydrolyzes ATP to exchange ions across the plasma membrane, exporting 3 Na(+) and importing 2 K(+) per cycle against electrochemical gradients. The beta subunit is important for the folding, stability, and targeting of the Na(+)/K(+)-ATPase pump to the plasma membranes (By similarity). In addition, acts as a homotypic cell adhesion molecule in epithelia cells. Interactions between ATP1B1 on neighboring cells are critical for proper lateral polarization of the Na(+)/K(+)-ATPase pump and for stabilizing cell-cell adhesion (By similarity). Plays a role in innate immunity by enhancing virus-triggered induction of interferons (IFNs) and interferon stimulated genes (ISGs). Mechanistically, enhances the ubiquitination of TRAF3 and TRAF6 as well as the phosphorylation of TAK1 and TBK1 (PubMed:34011520). {ECO:0000250|UniProtKB:P06583, ECO:0000250|UniProtKB:Q91580, ECO:0000269|PubMed:19694409, ECO:0000269|PubMed:34011520}.
uniprot
proteins
mass_dalton
35061
uniprot
proteins
post_translational_modification
PTM: Glutathionylated (By similarity). N-glycosylated; promotes the stability of ATP1B1 homotypic interactions (By similarity). {ECO:0000250|UniProtKB:P07340, ECO:0000250|UniProtKB:P14094}.; PTM: Ubiquitinated by RNF183 leading to its lysosomal degradation. {ECO:0000269|PubMed:31732153}.
uniprot
proteins
protein_family
X(+)/potassium ATPases subunit beta family
uniprot
proteins
pubmed
12754519
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19694409
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22328087
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2555225
uniprot
proteins
pubmed
2559024
uniprot
proteins
pubmed
25902260
uniprot
proteins
pubmed
3008098
uniprot
proteins
pubmed
31732153
uniprot
proteins
pubmed
34011520
uniprot
proteins
pubmed
35803952
uniprot
proteins
pubmed
36075933
uniprot
proteins
pubmed
39596464
uniprot
proteins
pubmed
7536695
uniprot
proteins
sequence_length
303
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:34011520}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P05027}. Apical cell membrane {ECO:0000250|UniProtKB:P07340}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P05027}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P14094}. Note=Colocalizes with OBSCN at the intercalated disk and sarcolemma in cardiomyocytes. Localizes in long striations at the level of Z and M lines. {ECO:0000250|UniProtKB:P14094}.
uniprot
proteins
transmembrane_region
TRANSMEM 35..62; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000250|UniProtKB:P05027
uniprot
proteins