DIO3
entrez
1735
canonical
uniprot
P55073
canonical
ensembl
ENSG00000197406
resolver
ensp
ENSP00000427336
resolver
enst
ENST00000510508
resolver
genesymbol
DIO3
resolver
genesymbol_syn
ITDI3
resolver
genesymbol_syn
TXDI3
resolver
hgnc
HGNC:2885
resolver
uniprot
G3XAM0
resolver
uniprot
Q86TU3
resolver
uniprot
Q8WVN5
resolver
uniprot_entry
IOD3_HUMAN
resolver
uniprot_entry
Q86TU3_HUMAN
resolver
uniprot_sec
G3XAM0
resolver
uniprot_sec
Q8WVN5
resolver
amino_acid_sequence
MPRQATSRLVVGEGEGSQGASGPAATMLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLGRRRRGQPEPEVELNSEGEEVPPDDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVLPDGFQSQHILDYAQGNRPLVLNFGSCTUPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYIIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLERYDEQLHGARPRRV
uniprot
proteins
ec_number
1.21.99.3
uniprot
proteins
function
FUNCTION: Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination (PubMed:7593630, PubMed:12586771, PubMed:12746313, PubMed:18821722). Catalyzes the deiodination of L-thyroxine (T4) to 3,3',5'-triiodothyronine (rT3), 3,5,3'-triiodothyronine (T3) to 3,3'-diiodothyronine (3,3'-T2), 3,5-diiodothyronine (3,5-T2) to 3-monoiodothyronine (3-T1), rT3 to 3',5'-diiodothyronine (3',5'-T2) and 3,3'-T2 to 3'-monoiodothyronine (3'-T1) via inner-ring deiodination (IRD) (PubMed:7593630, PubMed:12586771, PubMed:12746313, PubMed:18821722, PubMed:18339710). Catalyzes the deiodination of 3-T1 to L-thyronine (T0) via outer-ring deiodination (ORD) (PubMed:18821722). Catalyzes the tyrosyl ring deiodinations of 3,3',5,5'-tetraiodothyronamine, 3,3',5'-triiodothyronamine, 3,5,3'-triiodothyronamine, 3,5-diiodothyronamine, 3,3'-diiodothyronamine and 3-iodothyronamine (PubMed:18339710). {ECO:0000269|PubMed:12586771, ECO:0000269|PubMed:12746313, ECO:0000269|PubMed:18339710, ECO:0000269|PubMed:18821722, ECO:0000269|PubMed:7593630}.
uniprot
proteins
mass_dalton
33947
uniprot
proteins
mutagenesis
MUTAGEN 170; /note="U->A: Complete loss of enzyme activity towards 3,5,3'-triiodothyronine."; /evidence="ECO:0000269|PubMed:12746313
uniprot
proteins
protein_family
Iodothyronine deiodinase family
uniprot
proteins
pubmed
12419801
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
12586771
uniprot
proteins
pubmed
12746313
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18339710
uniprot
proteins
pubmed
18356288
uniprot
proteins
pubmed
18821722
uniprot
proteins
pubmed
7593630
uniprot
proteins
sequence_length
304
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12419801}; Single-pass type II membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:12419801}; Single-pass type II membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 45..67; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins