Crh
entrez
12918
canonical
uniprot
Q8CIT0
canonical
ensembl
ENSMUSG00000049796
resolver
ensp
ENSMUSP00000061185
resolver
enst
ENSMUST00000061294
resolver
genesymbol
Crh
resolver
genesymbol_syn
Gm1347
resolver
uniprot
Q14AA2
resolver
uniprot_entry
CRH_MOUSE
resolver
uniprot_sec
Q14AA2
resolver
activity_regulation
ACTIVITY REGULATION: Specifically inhibited by CRHBP, which prevents binding to CRH receptors CRHR1 and CRHR2. {ECO:0000269|PubMed:27641503}.
uniprot
proteins
amino_acid_sequence
MRLRLLVSAGMLLVALSSCLPCRALLSRGSVPRAPRAPQPLNFLQPEQPQQPQPVLIRMGEEYFLRLGNLNRSPAARLSPNSTPLTAGRGSRPSHDQAAANFFRVLLQQLQMPQRSLDSRAEPAERGAEDALGGHQGALERERRSEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEIIGK
uniprot
proteins
function
FUNCTION: Hormone that plays a central role in whole body adaptation to stress (PubMed:16682628, PubMed:22992525, PubMed:23470617, PubMed:7830793). Released by the hypothalamus primarily in response to physical or psychological stress and acts by binding to CRH receptor CRHR1, and to a lower extent, CRHR2 (PubMed:22992525). CRH-dependent signaling is a primary mediator of the neuroendocrine, autonomic (fight-or-flight) and behavioral responses to stress, acting as a key regulator of adaptation by activating the hypothalamus-pituitary-adrenal axis, leading to corticotropin hormone (ACTH) production (PubMed:22992525). Also involved in social behavior by triggering a signaling in the prefrontal cortex that favor social interactions with novel conspecifics over familiar ones (PubMed:37669667). Acts as a 'placental clock' during pregnancy, regulating gestational length, fetal development and the timing of labor (By similarity). Also acts as a regulator of blastocyst implantation by promoting decidualization, regulating trophoblast invasion and facilitating maternal immune tolerance (By similarity). {ECO:0000250|UniProtKB:P06850, ECO:0000269|PubMed:16682628, ECO:0000269|PubMed:22992525, ECO:0000269|PubMed:23470617, ECO:0000269|PubMed:37669667, ECO:0000269|PubMed:7830793}.
uniprot
proteins
mass_dalton
20778
uniprot
proteins
post_translational_modification
PTM: The precursor protein is cleaved into corticotropin-releasing hormone (CRH) by neuroendocrine convertases PCSK2. It is then amidated at the C-terminus, completing its activation. {ECO:0000250|UniProtKB:P06850}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16682628
uniprot
proteins
pubmed
19912808
uniprot
proteins
pubmed
22992525
uniprot
proteins
pubmed
23470617
uniprot
proteins
pubmed
27641503
uniprot
proteins
pubmed
37669667
uniprot
proteins
pubmed
7830793
uniprot
proteins
sequence_length
187
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:37669667}.
uniprot
proteins