TNFRSF10A
entrez
8797
canonical
uniprot
O00220
canonical
ensembl
ENSG00000104689
resolver
ensp
ENSP00000221132
resolver
enst
ENST00000221132
resolver
genesymbol
TNFRSF10A
resolver
genesymbol_syn
APO2
resolver
genesymbol_syn
DR4
resolver
genesymbol_syn
TRAILR1
resolver
hgnc
HGNC:11904
resolver
uniprot
A8K5I4
resolver
uniprot
Q53Y72
resolver
uniprot
Q96E62
resolver
uniprot_entry
TR10A_HUMAN
resolver
uniprot_sec
A8K5I4
resolver
uniprot_sec
Q53Y72
resolver
uniprot_sec
Q96E62
resolver
amino_acid_sequence
MAPPPARVHLGAFLAVTPNPGSAASGTEAAAATPSKVWGSSAGRIEPRGGGRGALPTSMGQHGPSARARAGRAPGPRPAREASPRLRVHKTFKFVVVGVLLQVVPSSAATIKLHDQSIGTQQWEHSPLGELCPPGSHRSEHPGACNRCTEGVGYTNASNNLFACLPCTACKSDEEERSPCTTTRNTACQCKPGTFRNDNSAEMCRKCSRGCPRGMVKVKDCTPWSDIECVHKESGNGHNIWVILVVTLVVPLLLVAVLIVCCCIGSGCGGDPKCMDRVCFWRLGLLRGPGAEDNAHNEILSNADSLSTFVSEQQMESQEPADLTGVTVQSPGEAQCLLGPAEAEGSQRRRLLVPANGADPTETLMLFFDKFANIVPFDSWDQLMRQLDLTKNEIDVVRAGTAGPGDALYAMLMKWVNKTGRNASIHTLLDALERMEERHAREKIQDLLVDSGKFIYLEDGTGSAVSLE
uniprot
proteins
function
FUNCTION: Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518, PubMed:38532423). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (PubMed:19090789). Promotes the activation of NF-kappa-B (PubMed:9430227). {ECO:0000269|PubMed:19090789, ECO:0000269|PubMed:38532423, ECO:0000269|PubMed:9430227}.
uniprot
proteins
mass_dalton
50089
uniprot
proteins
mutagenesis
MUTAGEN 261; /note="C->S: No effect on palmitoylation. Loss of palmitoylation, decreased association with membranes, decreased oligomerization, decreased death-induced signaling complex assembly associated with decreased function in TRAIL-induced cell death; when associated with S-262 and S-263."; /evidence="ECO:0000269|PubMed:19090789, ECO:0000269|PubMed:22240897"; MUTAGEN 262; /note="C->S: No effect on palmitoylation. Loss of palmitoylation, decreased association with membranes, decreased oligomerization, decreased death-induced signaling complex assembly associated with decreased function in TRAIL-induced cell death; when associated with S-261 and S-263."; /evidence="ECO:0000269|PubMed:19090789"; MUTAGEN 263; /note="C->S: No effect on palmitoylation. Loss of palmitoylation, decreased association with membranes, decreased oligomerization, decreased death-induced signaling complex assembly associated with decreased function in TRAIL-induced cell death; when associated with S-261 and S-262."; /evidence="ECO:0000269|PubMed:19090789"; MUTAGEN 268; /note="C->S: No effect on palmitoylation."; /evidence="ECO:0000269|PubMed:19090789"; MUTAGEN 274; /note="C->S: No effect on palmitoylation."; /evidence="ECO:0000269|PubMed:19090789"; MUTAGEN 279; /note="C->S: No effect on palmitoylation."; /evidence="ECO:0000269|PubMed:19090789
uniprot
proteins
post_translational_modification
PTM: Palmitoylated (PubMed:19090789). Palmitoylation of TNFRSF10A is required for its association with lipid rafts, oligomerization and function in TRAIL-induced cell death (PubMed:19090789). Palmitoylated by ZDHHC3 (Probable). {ECO:0000269|PubMed:19090789, ECO:0000305|PubMed:22240897}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18165900
uniprot
proteins
pubmed
18846110
uniprot
proteins
pubmed
19090789
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
22240897
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23498957
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
26457518
uniprot
proteins
pubmed
38532423
uniprot
proteins
pubmed
9082980
uniprot
proteins
pubmed
9430227
uniprot
proteins
sequence_length
468
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22240897}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:19090789, ECO:0000269|PubMed:22240897}. Cytoplasm, cytosol {ECO:0000269|PubMed:22240897}. Note=Palmitoylation is required for association with membranes. {ECO:0000269|PubMed:22240897}.
uniprot
proteins
transmembrane_region
TRANSMEM 240..262; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins