Bcl2l1
entrez
24888
canonical
uniprot
P53563
canonical
ensembl
ENSRNOG00000007946
resolver
ensp
ENSRNOP00000043542
resolver
ensp
ENSRNOP00000105017
resolver
ensp
ENSRNOP00000106948
resolver
enst
ENSRNOT00000047416
resolver
enst
ENSRNOT00000129836
resolver
enst
ENSRNOT00000170561
resolver
genesymbol
Bcl2l1
resolver
genesymbol_syn
Bcl-x
resolver
genesymbol_syn
Bclx
resolver
genesymbol_syn
Blc2l
resolver
uniprot
A0ABK0LMV6
resolver
uniprot
A6KHR6
resolver
uniprot
P70613
resolver
uniprot
P70614
resolver
uniprot
Q52KS0
resolver
uniprot
Q548R7
resolver
uniprot
Q62678
resolver
uniprot
Q62836
resolver
uniprot
Q64087
resolver
uniprot
Q64128
resolver
uniprot
Q7TS62
resolver
uniprot_entry
A0ABK0LMV6_RAT
resolver
uniprot_entry
B2CL1_RAT
resolver
uniprot_entry
Q548R7_RAT
resolver
uniprot_entry
Q7TS62_RAT
resolver
uniprot_sec
A6KHR6
resolver
uniprot_sec
P70613
resolver
uniprot_sec
P70614
resolver
uniprot_sec
Q52KS0
resolver
uniprot_sec
Q62678
resolver
uniprot_sec
Q62836
resolver
uniprot_sec
Q64087
resolver
uniprot_sec
Q64128
resolver
amino_acid_sequence
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEETEPERETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIASWMATYLNDHLEPWIQENGGWDTFVDLYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
uniprot
proteins
function
FUNCTION: Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis.; FUNCTION: Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles. May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity). {ECO:0000250|UniProtKB:Q07817, ECO:0000269|PubMed:18250306, ECO:0000269|PubMed:21926988, ECO:0000269|PubMed:23792689, ECO:0000269|PubMed:7828536, ECO:0000269|PubMed:8662675}.; FUNCTION: Isoform Bcl-X(S) promotes apoptosis.
uniprot
proteins
mass_dalton
26158
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity (By similarity). {ECO:0000250}.; PTM: Phosphorylated on Ser-62 by CDK1. This phosphorylation is partial in normal mitotic cells, but complete in G2-arrested cells upon DNA-damage, thus promoting subsequent apoptosis probably by triggering caspases-mediated proteolysis. Phosphorylated by PLK3, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Phosphorylation at Ser-49 appears during the S phase and G2, disappears rapidly in early mitosis during prometaphase, metaphase and early anaphase, and re-appears during telophase and cytokinesis (By similarity). {ECO:0000250}.; PTM: Ubiquitinated by RNF183 during prolonged ER stress, leading to degradation by the proteosome. {ECO:0000250|UniProtKB:Q07817}.
uniprot
proteins
protein_family
Bcl-2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18250306
uniprot
proteins
pubmed
21926988
uniprot
proteins
pubmed
23792689
uniprot
proteins
pubmed
7828536
uniprot
proteins
pubmed
8662675
uniprot
proteins
pubmed
9346936
uniprot
proteins
sequence_length
233
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform Bcl-X(L)]: Mitochondrion inner membrane. Mitochondrion outer membrane. Mitochondrion matrix. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Localizes to the centrosome when phosphorylated at Ser-49 (By similarity). After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 210..226; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins