AMD1
entrez
262
canonical
uniprot
P17707
canonical
ensembl
ENSG00000123505
resolver
ensp
ENSP00000357870
resolver
ensp
ENSP00000357871
resolver
ensp
ENSP00000357880
resolver
ensp
ENSP00000502112
resolver
ensp
ENSP00000610295
resolver
enst
ENST00000368876
resolver
enst
ENST00000368877
resolver
enst
ENST00000675380
resolver
genesymbol
AMD1
resolver
genesymbol_syn
AMD
resolver
hgnc
HGNC:457
resolver
uniprot
A0A088AWN0
resolver
uniprot
A0A6Q8PG53
resolver
uniprot
A6NNH3
resolver
uniprot
B4DTR6
resolver
uniprot
B4DZ60
resolver
uniprot
B4E2N2
resolver
uniprot
E1P5F7
resolver
uniprot
Q5VXN4
resolver
uniprot
Q5VXN5
resolver
uniprot
Q5VXN6
resolver
uniprot
Q9BWK4
resolver
uniprot_entry
A0A088AWN0_HUMAN
resolver
uniprot_entry
A0A6Q8PG53_HUMAN
resolver
uniprot_entry
B4DZ60_HUMAN
resolver
uniprot_entry
B4E2N2_HUMAN
resolver
uniprot_entry
DCAM_HUMAN
resolver
uniprot_entry
Q5VXN5_HUMAN
resolver
uniprot_sec
A6NNH3
resolver
uniprot_sec
B4DTR6
resolver
uniprot_sec
E1P5F7
resolver
uniprot_sec
Q5VXN4
resolver
uniprot_sec
Q5VXN6
resolver
uniprot_sec
Q9BWK4
resolver
activity_regulation
ACTIVITY REGULATION: Both proenzyme processing and catalytic activity are stimulated by putrescine. Catalytic activity is inhibited by iodoacetic acid.
uniprot
proteins
amino_acid_sequence
MEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRSEWDILLKDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDFPESRVISQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATMFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLASPQKIEGFKRLDCQSAMFNDYNFVFTSFAKKQQQQQS
uniprot
proteins
ec_number
4.1.1.50
uniprot
proteins
function
FUNCTION: Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. {ECO:0000250|UniProtKB:P0DMN7}.
uniprot
proteins
mass_dalton
38340
uniprot
proteins
mutagenesis
MUTAGEN 7; /note="F->A: No effect."; /evidence="ECO:0000269|PubMed:11583147"; MUTAGEN 8; /note="E->Q: Loss of activity. Normal putrescine-stimulated processing."; /evidence="ECO:0000269|PubMed:10029540, ECO:0000269|PubMed:1917972"; MUTAGEN 11; /note="E->Q: Loss of activity. Loss of putrescine-stimulated processing."; /evidence="ECO:0000269|PubMed:1917972"; MUTAGEN 15; /note="E->Q: Little effect."; /evidence="ECO:0000269|PubMed:1917972"; MUTAGEN 49; /note="C->A: Little effect."; /evidence="ECO:0000269|PubMed:1917972"; MUTAGEN 50; /note="S->A: 17 percent decrease in catalytic activity. No effect on processing."; /evidence="ECO:0000269|PubMed:2687270"; MUTAGEN 61; /note="E->Q: Little effect."; /evidence="ECO:0000269|PubMed:1917972"; MUTAGEN 66; /note="S->A: 38 percent decrease in catalytic activity. Slight reduction in processing."; /evidence="ECO:0000269|PubMed:2687270"; MUTAGEN 67; /note="E->Q: Little effect."; /evidence="ECO:0000269|PubMed:1917972"; MUTAGEN 68..69; /note="SS->II: Loss of catalytic activity and processing."; /evidence="ECO:0000269|PubMed:2687270"; MUTAGEN 68; /note="S->A: Loss of catalytic activity and processing."; /evidence="ECO:0000269|PubMed:2687270"; MUTAGEN 69; /note="S->A: 24 percent decrease in catalytic activity. Slight reduction in processing."; /evidence="ECO:0000269|PubMed:2687270"; MUTAGEN 80; /note="K->A: Greatly reduced catalytic activity. No putrescine-stimulated processing."; /evidence="ECO:0000269|PubMed:1917972"; MUTAGEN 82; /note="C->A: Loss of activity. Greatly reduced putrescine-stimulated processing."; /evidence="ECO:0000269|PubMed:1917972"; MUTAGEN 223; /note="F->A: No effect."; /evidence="ECO:0000269|PubMed:11583147"; MUTAGEN 226; /note="C->A: Little effect."; /evidence="ECO:0000269|PubMed:1917972"; MUTAGEN 229; /note="S->A: Loss of processing."; /evidence="ECO:0000269|PubMed:10574985"; MUTAGEN 229; /note="S->C: Greatly reduced processing."; /evidence="ECO:0000269|PubMed:10574985"; MUTAGEN 229; /note="S->T: Greatly reduced catalytic activity but little effect on processing."; /evidence="ECO:0000269|PubMed:10574985"; MUTAGEN 243; /note="H->A: Greatly reduced catalytic activity and processing."; /evidence="ECO:0000269|PubMed:10574985"; MUTAGEN 243; /note="H->E: Greatly reduced catalytic activity and processing."; /evidence="ECO:0000269|PubMed:10574985"; MUTAGEN 243; /note="H->F: Loss of processing."; /evidence="ECO:0000269|PubMed:10574985"; MUTAGEN 243; /note="H->Y: Loss of processing."; /evidence="ECO:0000269|PubMed:10574985"; MUTAGEN 247; /note="E->Q: Little effect."; /evidence="ECO:0000269|PubMed:1917972"; MUTAGEN 249; /note="E->Q: Little effect."; /evidence="ECO:0000269|PubMed:1917972
uniprot
proteins
pathway_participation
PATHWAY: Amine and polyamine biosynthesis; S-adenosylmethioninamine biosynthesis; S-adenosylmethioninamine from S-adenosyl-L-methionine: step 1/1. {ECO:0000269|PubMed:10029540, ECO:0000269|PubMed:10574985, ECO:0000269|PubMed:11583147, ECO:0000269|PubMed:1917972, ECO:0000269|PubMed:2460457, ECO:0000269|PubMed:2687270}.
uniprot
proteins
post_translational_modification
PTM: Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain. {ECO:0000269|PubMed:10574985, ECO:0000269|PubMed:1917972, ECO:0000269|PubMed:2460457, ECO:0000269|PubMed:2687270}.
uniprot
proteins
protein_family
Eukaryotic AdoMetDC family
uniprot
proteins
pubmed
10029540
uniprot
proteins
pubmed
10378277
uniprot
proteins
pubmed
10574985
uniprot
proteins
pubmed
11583147
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
1917972
uniprot
proteins
pubmed
2460457
uniprot
proteins
pubmed
2687270
uniprot
proteins
sequence_length
334
uniprot
proteins