Ccr3
entrez
12771
canonical
uniprot
P51678
canonical
ensembl
ENSMUSG00000035448
resolver
ensp
ENSMUSP00000039107
resolver
enst
ENSMUST00000039171
resolver
genesymbol
Ccr3
resolver
genesymbol_syn
Cmkbr1l2
resolver
genesymbol_syn
Cmkbr3
resolver
uniprot
Q3U5L7
resolver
uniprot
Q8K3M7
resolver
uniprot_entry
CCR3_MOUSE
resolver
uniprot_entry
Q3U5L7_MOUSE
resolver
uniprot_sec
Q8K3M7
resolver
amino_acid_sequence
MAFNTDEIKTVVESFETTPYEYEWAPPCEKVRIKELGSWLLPPLYSLVFIIGLLGNMMVVLILIKYRKLQIMTNIYLFNLAISDLLFLFTVPFWIHYVLWNEWGFGHYMCKMLSGFYYLALYSEIFFIILLTIDRYLAIVHAVFALRARTVTFATITSIITWGLAGLAALPEFIFHESQDSFGEFSCSPRYPEGEEDSWKRFHALRMNIFGLALPLLIMVICYSGIIKTLLRCPNKKKHKAIRLIFVVMIVFFIFWTPYNLVLLFSAFHSTFLETSCQQSKHLDLAMQVTEVIAYTHCCINPVIYAFVGERFRKHLRLFFHRNVAVYLGKYIPFLPGEKMERTSSVSPSTGEQEISVVF
uniprot
proteins
function
FUNCTION: G protein-coupled receptor (GPCR) that plays a key role in the immune system by regulating the migration and activation of white blood cells in response to chemokines. Selectively interacts with eosinophil-attracting chemokines such as eotaxin/CCL11, eotaxin-2/CCL24 and eotaxin-3/CCL26. Ligand binding triggers intracellular signaling that leads to chemotaxis of immune cells. Mechanistically, signals through GNA14 or GNA16 to induce stimulation of phospholipase Cbeta/PLCB2 and subsequently chemotaxis. Alternatively, transduces signal via GNAI1 resulting in elevated intracellular calcium levels and activation of the PI3K/AKT pathway. May also act as a possible functional receptor for NARS1. {ECO:0000250|UniProtKB:P51677}.
uniprot
proteins
mass_dalton
41783
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11830666
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
35780587
uniprot
proteins
pubmed
7542241
uniprot
proteins
pubmed
7594543
uniprot
proteins
sequence_length
359
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 39..64; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 69..95; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 112..133; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 151..175; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 202..227; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 244..268; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 286..309; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins