GPR15
entrez
2838
canonical
uniprot
P49685
canonical
ensembl
ENSG00000154165
resolver
ensp
ENSP00000284311
resolver
enst
ENST00000284311
resolver
genesymbol
GPR15
resolver
hgnc
HGNC:4469
resolver
uniprot
B2R8H6
resolver
uniprot
Q3MIL4
resolver
uniprot
Q6ISN6
resolver
uniprot_entry
B2R8H6_HUMAN
resolver
uniprot_entry
GPR15_HUMAN
resolver
uniprot_sec
Q3MIL4
resolver
uniprot_sec
Q6ISN6
resolver
amino_acid_sequence
MDPEETSVYLDYYYATSPNSDIRETHSHVPYTSVFLPVFYTAVFLTGVLGNLVLMGALHFKPGSRRLIDIFIINLAASDFIFLVTLPLWVDKEASLGLWRTGSFLCKGSSYMISVNMHCSVLLLTCMSVDRYLAIVWPVVSRKFRRTDCAYVVCASIWFISCLLGLPTLLSRELTLIDDKPYCAEKKATPIKLIWSLVALIFTFFVPLLSIVTCYCCIARKLCAHYQQSGKHNKKLKKSIKIIFIVVAAFLVSWLPFNTFKFLAIVSGLRQEHYLPSAILQLGMEVSGPLAFANSCVNPFIYYIFDSYIRRAIVHCLCPCLKNYDFGSSTETSDSHLTKALSTFIHAEDFARRRKRSVSL
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that plays an important role in immune homeostasis (PubMed:33758080, PubMed:38918398). Acts via its natural ligand GPR15LG, a chemokine-like polypeptide strongly expressed in gastrointestinal tissues. GPR15-GPR15LG signaling axis regulates intestinal homeostasis and inflammation through the migration of immune cells (PubMed:33758080, PubMed:38918398). Controls thereby the specific homing of T-cells, particularly FOXP3+ regulatory T-cells (Tregs), to the large intestine lamina propria (By similarity). Also required for skin localization of thymus-derived dendritic epidermal T-cells (By similarity). Plays an important role in mediating cytoprotective function as well as angiogenesis of thrombomodulin (By similarity). Mechanistically, preferentially signals through the Gi/o pathway to inhibit adenylate cyclase activity and activate a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (PubMed:35510660). {ECO:0000250|UniProtKB:Q0VDU3, ECO:0000269|PubMed:33758080, ECO:0000269|PubMed:35510660, ECO:0000269|PubMed:38918398}.; FUNCTION: (Microbial infection) Acts as an alternative coreceptor with CD4 for HIV-1 infection. {ECO:0000269|PubMed:9791028}.
uniprot
proteins
mass_dalton
40787
uniprot
proteins
mutagenesis
MUTAGEN 40; /note="Y->A: Complete loss of ligand-induced receptor activation."; /evidence="ECO:0000269|PubMed:38918398"; MUTAGEN 261; /note="K->A: Complete loss of ligand-induced receptor activation."; /evidence="ECO:0000269|PubMed:38918398"; MUTAGEN 356; /note="R->A: Abolished YWHAE binding."; /evidence="ECO:0000269|PubMed:21189250"; MUTAGEN 359; /note="S->A: Abolished YWHAE binding and substantially reduced cell surface expression."; /evidence="ECO:0000269|PubMed:21189250
uniprot
proteins
post_translational_modification
PTM: Phosphorylation is necessary for YWHAE binding and efficient surface expression. {ECO:0000269|PubMed:21189250}.; PTM: O-glycosylated (PubMed:21189250). Sialylated O-glycans in the N-terminal tail inhibits binding of GPR15LG (PubMed:33758080). {ECO:0000269|PubMed:21189250, ECO:0000269|PubMed:33758080}.; PTM: Sulfation is required for efficient binding of GPR15LG. {ECO:0000269|PubMed:33758080}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21189250
uniprot
proteins
pubmed
33758080
uniprot
proteins
pubmed
35510660
uniprot
proteins
pubmed
38918398
uniprot
proteins
pubmed
8838812
uniprot
proteins
pubmed
9791028
uniprot
proteins
sequence_length
360
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21189250}; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 34..54; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 70..90; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 121..141; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 150..170; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 193..213; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 240..260; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 285..305; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins