Q61618
uniprot
Q61618
canonical
amino_acid_sequence
MEADNTTETDWLNITYITMEAAIGLCAVVGNMLVIWVVKLNPTLRTTTVYFIVSLALADIAVGVLVIPLAIAVSLQVKMHFYACLFMSCVLLIFTHASIMSLLAIAVHRYLRVKLTVRYRTVTTQRRIWLFLGLCWLVSFLVGLTPMFGWNRKATLASSQNSSTLLCHFRSVVSLDYMVFFSFITWILVPLVVMCIIYLDIFYIIRNKLSQNLTGFRETRAFYGREFKTAKSLFLVLFLFALCWLPLSIINFVSYFDVKIPDVAMCLGILLSHANSMMNPIVYACKIKKFKETYFLILRAVRLCQTSDSLDSNMEQTTE
uniprot
proteins
function
FUNCTION: G protein-coupled receptor (GPCR) for adenosine that plays significant roles in various physiological processes including immune regulation, cardioprotection and neuroprotection (PubMed:10660615, PubMed:12817016). Also acts as a receptor for adenosines containing N(6)-methylated adenine (m6A) post-transcriptional modification, which are derived from the degradation of RNAs (mRNAs, rRNAs and tRNAs): activated by N(6)-methyladenosine (m6A), N(6),N(6)-dimethyladenosine (m6,6A) and N(6)-isopentenyladenosine (i6A) (By similarity). Preferentially couples to the inhibitory G protein (Gi), leading to the suppression of adenylate cyclase activity and a reduction in intracellular cyclic AMP levels (PubMed:10660615). Upon adenosine binding, mediates cardioprotection in cardiomyocytes through anti-apoptotic effects primarily via the ERK1/2 pathway as well as the PI3K pathway (By similarity). In the central nervous system, participates in the modulation of synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD) in the hippocampus (By similarity). In lung mast cells, receptor activation contributes to the type I allergic response by facilitating mast cell degranulation and histamine release (PubMed:12817016). Highly expressed in inflammatory cells such as neutrophils and mast cells, inhibits neutrophil degranulation and reduces superoxide production, thereby modulating inflammatory responses (By similarity). {ECO:0000250|UniProtKB:P0DMS8, ECO:0000250|UniProtKB:P28647, ECO:0000269|PubMed:10660615, ECO:0000269|PubMed:12817016}.
uniprot
proteins
mass_dalton
36449
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Thr-317 and Thr-318 may be crucial for rapid desensitization. Phosphorylation on Thr-317 may be necessary for phosphorylation on Thr-318 to occur. {ECO:0000250|UniProtKB:P28647}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10191095
uniprot
proteins
pubmed
10660615
uniprot
proteins
pubmed
12817016
uniprot
proteins
pubmed
8288218
uniprot
proteins
sequence_length
319
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12817016}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 16..39; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P0DMS8"; TRANSMEM 48..70; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P0DMS8"; TRANSMEM 85..107; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P0DMS8"; TRANSMEM 128..150; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P0DMS8"; TRANSMEM 173..198; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P0DMS8"; TRANSMEM 230..255; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P0DMS8"; TRANSMEM 264..285; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P0DMS8
uniprot
proteins