Crhr2
entrez
12922
canonical
uniprot
Q60748
canonical
ensembl
ENSMUSG00000003476
resolver
ensp
ENSMUSP00000003568
resolver
ensp
ENSMUSP00000093586
resolver
ensp
ENSMUSP00000110015
resolver
ensp
ENSMUSP00000148297
resolver
ensp
ENSMUSP00000148408
resolver
enst
ENSMUST00000095898
resolver
enst
ENSMUST00000114374
resolver
genesymbol
Crhr2
resolver
genesymbol_syn
Crf2r
resolver
uniprot
A0A1D5RLK7
resolver
uniprot
B9EHB5
resolver
uniprot
C0K3M3
resolver
uniprot
E9QNK5
resolver
uniprot
F7C3W4
resolver
uniprot
Q3UQP0
resolver
uniprot
Q5ERJ2
resolver
uniprot
Q5GL24
resolver
uniprot
Q60783
resolver
uniprot
Q60808
resolver
uniprot_entry
CRHR2_MOUSE
resolver
uniprot_entry
E9QNK5_MOUSE
resolver
uniprot_entry
F7C3W4_MOUSE
resolver
uniprot_entry
Q5ERJ2_MOUSE
resolver
uniprot_sec
A0A1D5RLK7
resolver
uniprot_sec
B9EHB5
resolver
uniprot_sec
C0K3M3
resolver
uniprot_sec
Q3UQP0
resolver
uniprot_sec
Q5GL24
resolver
uniprot_sec
Q60783
resolver
uniprot_sec
Q60808
resolver
amino_acid_sequence
MDAALLLSLLEANCSLALAEELLLDGWGVPPDPEGPYTYCNTTLDQIGTCWPQSAPGALVERPCPEYFNGIKYNTTRNAYRECLENGTWASRVNYSHCEPILDDKQRKYDLHYRIALIVNYLGHCVSVVALVAAFLLFLVLRSIRCLRNVIHWNLITTFILRNIAWFLLQLIDHEVHEGNEVWCRCITTIFNYFVVTNFFWMFVEGCYLHTAIVMTYSTEHLRKWLFLFIGWCIPCPIIIAWAVGKLYYENEQCWFGKEAGDLVDYIYQGPVMLVLLINFVFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDDLSQIVFIYFNSFLQSFQGFFVSVFYCFFNGEVRAALRKRWHRWQDHHALRVPVARAMSIPTSPTRISFHSIKQTAAV
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for CRH, UCN, UCN2 and UCN3 stress hormones, which plays a central role in whole body adaptation to stress (PubMed:10742107, PubMed:10742108, PubMed:10742109). Has highest affinity for UCN, and much lower affinity for CRH, UNC2 and UCN3 (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and downstream effectors, such as adenylate cyclase (By similarity). CRHR2 is coupled to G(s) G protein (GNAS), mediating activation of adenylate cyclase activity and production of cAMP (By similarity). CRHR2-dependent signaling is a primary mediator of the neuroendocrine, autonomic (fight-or-flight) and behavioral responses to stress, acting as a key regulator of adaptation by activating the hypothalamus-pituitary-adrenal axis, leading to corticotropin hormone (ACTH) production (PubMed:10742107, PubMed:10742108, PubMed:10742109). {ECO:0000250|UniProtKB:Q13324, ECO:0000269|PubMed:10742107, ECO:0000269|PubMed:10742108, ECO:0000269|PubMed:10742109}.
uniprot
proteins
mass_dalton
47623
uniprot
proteins
mutagenesis
MUTAGEN 45; /note="D->A: Disrupts internal salt bridge and abrogates ligand recognition."; /evidence="ECO:0000269|PubMed:16888152
uniprot
proteins
post_translational_modification
PTM: A N-glycosylation site within the signal peptide impedes its proper cleavage and function. {ECO:0000250|UniProtKB:P47866}.
uniprot
proteins
protein_family
G protein-coupled receptor 2 family
uniprot
proteins
pubmed
10742107
uniprot
proteins
pubmed
10742108
uniprot
proteins
pubmed
10742109
uniprot
proteins
pubmed
15326300
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15514029
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16888152
uniprot
proteins
pubmed
17360332
uniprot
proteins
pubmed
19246489
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
7565810
uniprot
proteins
pubmed
7708757
uniprot
proteins
pubmed
7755719
uniprot
proteins
sequence_length
411
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19246489}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:19246489}. Endoplasmic reticulum {ECO:0000269|PubMed:19246489}. Golgi apparatus membrane {ECO:0000269|PubMed:19246489}. Note=In the presence of isoform 3, retained in the endoplasmic reticulum - Golgi complex. {ECO:0000269|PubMed:19246489}.; SUBCELLULAR LOCATION: [Isoform 3]: Endoplasmic reticulum {ECO:0000269|PubMed:19246489}. Golgi apparatus {ECO:0000269|PubMed:19246489}. Note=Contrary to isoform 2, not expressed at the plasma membrane, but remains rather in the endoplasmic reticulum - Golgi complex. {ECO:0000269|PubMed:19246489}.
uniprot
proteins
transmembrane_region
TRANSMEM 114..139; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q13324"; TRANSMEM 150..171; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q13324"; TRANSMEM 183..210; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q13324"; TRANSMEM 224..245; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q13324"; TRANSMEM 264..288; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q13324"; TRANSMEM 308..326; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q13324"; TRANSMEM 335..362; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q13324
uniprot
proteins