F3
entrez
2152
canonical
uniprot
P13726
canonical
ensembl
ENSG00000117525
resolver
ensp
ENSP00000334145
resolver
ensp
ENSP00000359226
resolver
genesymbol
F3
resolver
hgnc
HGNC:3541
resolver
uniprot
D3DT47
resolver
uniprot
Q6FHG2
resolver
uniprot
Q86WH4
resolver
uniprot_entry
TF_HUMAN
resolver
uniprot_sec
D3DT47
resolver
uniprot_sec
Q6FHG2
resolver
uniprot_sec
Q86WH4
resolver
amino_acid_sequence
METPAWPRVPRPETAVARTLLLGWVFAQVAGASGTTNTVAAYNLTWKSTNFKTILEWEPKPVNQVYTVQISTKSGDWKSKCFYTTDTECDLTDEIVKDVKQTYLARVFSYPAGNVESTGSAGEPLYENSPEFTPYLETNLGQPTIQSFEQVGTKVNVTVEDERTLVRRNNTFLSLRDVFGKDLIYTLYYWKSSSSGKKTAKTNTNEFLIDVDKGENYCFSVQAVIPSRTVNRKSTDSPVECMGQEKGEFREIFYIIGAVVFVVIILVIILAISLHKCRKAGVGQSWKENSPLNVS
uniprot
proteins
function
FUNCTION: Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. {ECO:0000269|PubMed:12652293, ECO:0000269|PubMed:271951}.
uniprot
proteins
mass_dalton
33068
uniprot
proteins
protein_family
Tissue factor family
uniprot
proteins
pubmed
12652293
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19168442
uniprot
proteins
pubmed
20634491
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
271951
uniprot
proteins
pubmed
2719931
uniprot
proteins
pubmed
2823875
uniprot
proteins
pubmed
3037536
uniprot
proteins
pubmed
3166978
uniprot
proteins
pubmed
3297348
uniprot
proteins
pubmed
3424286
uniprot
proteins
pubmed
8086403
uniprot
proteins
pubmed
8598903
uniprot
proteins
pubmed
8609606
uniprot
proteins
pubmed
9925787
uniprot
proteins
sequence_length
295
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Membrane {ECO:0000269|PubMed:12652293}; Single-pass type I membrane protein {ECO:0000269|PubMed:12652293}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:12652293}.
uniprot
proteins
transmembrane_region
TRANSMEM 252..274; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins