Fbxw7
entrez
50754
canonical
uniprot
Q8VBV4
canonical
ensembl
ENSMUSG00000028086
resolver
ensp
ENSMUSP00000029727
resolver
ensp
ENSMUSP00000103302
resolver
ensp
ENSMUSP00000103305
resolver
ensp
ENSMUSP00000103306
resolver
enst
ENSMUST00000107675
resolver
genesymbol
Fbxw7
resolver
genesymbol_syn
Fbw7
resolver
genesymbol_syn
Fbwd6
resolver
genesymbol_syn
Fbxw6
resolver
uniprot
A2RRI5
resolver
uniprot
D3YUA5
resolver
uniprot
D3YUA8
resolver
uniprot
Q8CCS5
resolver
uniprot
Q8VHP4
resolver
uniprot_entry
D3YUA8_MOUSE
resolver
uniprot_entry
FBXW7_MOUSE
resolver
uniprot_sec
A2RRI5
resolver
uniprot_sec
D3YUA5
resolver
uniprot_sec
Q8CCS5
resolver
uniprot_sec
Q8VHP4
resolver
amino_acid_sequence
MNQELLSVGSKRRRTGGSLRGNASSSQVDEGQMNRVVEEDPQQQARHQEEEHTARNGELVGANPRPGDQNDTQQGQVEENNNRFISVDEDSSGNQEEQEEDEEHAGEQEEEEEEEEEEEEMDQESDDFDPSDDSSREDEHTHNSNVTNCSSVSDLPAHQLSSPFYTKTTKMKRKLDHGSEVRSFSLGKKPCKVSDYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKIIKPGFIHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPSKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDMK
uniprot
proteins
function
FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:21953459, PubMed:22748924). Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter brings them to the SCF complex for ubiquitination (PubMed:22748924). Mediates ubiquitination and subsequent degradation of CCNE1 and MYC (PubMed:22748924). Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, MLST8, RICTOR and probably PSEN1 (By similarity). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (By similarity). SCF(FBXW7) complex mediates the ubiquitination and subsequent degradation of NFE2L1 (PubMed:21953459). Involved in bone homeostasis and negative regulation of osteoclast differentiation (PubMed:29149593). Regulates the amplitude of the cyclic expression of hepatic core clock genes and genes involved in lipid and glucose metabolism via ubiquitination and proteasomal degradation of their transcriptional repressor NR1D1; CDK1-dependent phosphorylation of NR1D1 is necessary for SCF(FBXW7)-mediated ubiquitination (PubMed:27238018). Also able to promote 'Lys-63'-linked ubiquitination in response to DNA damage (By similarity). The SCF(FBXW7) complex facilitates double-strand break repair following phosphorylation by ATM: phosphorylation promotes localization to sites of double-strand breaks and 'Lys-63'-linked ubiquitination of phosphorylated XRCC4, enhancing DNA non-homologous end joining (By similarity). {ECO:0000250|UniProtKB:Q969H0, ECO:0000269|PubMed:21953459, ECO:0000269|PubMed:22748924, ECO:0000269|PubMed:27238018, ECO:0000269|PubMed:29149593}.
uniprot
proteins
mass_dalton
79848
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:21953459, ECO:0000269|PubMed:22748924}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-208 promotes interaction with PIN1, leading to disrupt FBXW7 dimerization and promoting FBXW7 autoubiquitination and degradation. Phosphorylated by ATM at Ser-26 in response to DNA damage, promoting recruitment to DNA damage sites and 'Lys-63'-linked ubiquitination of phosphorylated XRCC4. {ECO:0000250|UniProtKB:Q969H0}.; PTM: Ubiquitinated: autoubiquitinates following phosphorylation at Thr-208 and subsequent interaction with PIN1 (By similarity). Ubiquitination leads to its proteasomal degradation (PubMed:22748924). {ECO:0000250|UniProtKB:Q969H0, ECO:0000269|PubMed:22748924}.
uniprot
proteins
pubmed
11425854
uniprot
proteins
pubmed
11461910
uniprot
proteins
pubmed
11735228
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21953459
uniprot
proteins
pubmed
22748924
uniprot
proteins
pubmed
27238018
uniprot
proteins
pubmed
29149593
uniprot
proteins
sequence_length
710
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:11461910}. Chromosome {ECO:0000250|UniProtKB:Q969H0}. Note=Localizes to site of double-strand breaks following phosphorylation by ATM. {ECO:0000250|UniProtKB:Q969H0}.
uniprot
proteins