Nfkbiz
entrez
80859
canonical
uniprot
Q9EST8
canonical
ensembl
ENSMUSG00000035356
resolver
ensp
ENSMUSP00000041173
resolver
ensp
ENSMUSP00000110101
resolver
ensp
ENSMUSP00000110102
resolver
genesymbol
Nfkbiz
resolver
genesymbol_syn
Inap
resolver
genesymbol_syn
Mail
resolver
uniprot
Q3TVL7
resolver
uniprot
Q3TWK9
resolver
uniprot
Q3U8Y9
resolver
uniprot
Q3UCI2
resolver
uniprot
Q3URP0
resolver
uniprot
Q3UW99
resolver
uniprot
Q5NT97
resolver
uniprot
Q99NA4
resolver
uniprot_entry
IKBZ_MOUSE
resolver
uniprot_sec
Q3TVL7
resolver
uniprot_sec
Q3TWK9
resolver
uniprot_sec
Q3U8Y9
resolver
uniprot_sec
Q3UCI2
resolver
uniprot_sec
Q3URP0
resolver
uniprot_sec
Q3UW99
resolver
uniprot_sec
Q5NT97
resolver
uniprot_sec
Q99NA4
resolver
amino_acid_sequence
MIVDKLLDDSRGGEGLLDAAGDCGLMTSPLNLAYFYGASPPSAPGAGDTGYLSAVPSAPGSPGSDSSDFSSTSSVSSCGAVESRPRGGARAERPQVEPHMGVGRQQRGPFQGVRVKNSVKELLLHIRSNKQKASGQPVDEFKTQSVNIEQLTDLKSAVSAVGKRKGPDPLSDGPVCKRPALLPSHFVTSPQTPTPGESMEDVRHSESKLDSSAALLQNIINIKNECNPVSLNTVQVSWMSPTVPQNSPRDQCQDFHGGQAFSPPQKYQPFQVSGSPQMMDQASMYQYSPQTQNMQQPPPLPPQQQHQQNYPHNSPLQFSPYSRMSQSPKYDSNLFDTHEPQFCTGQSFVSLLTGPGEPESLAVPVPAPTSIPPQTETQLQTFSLMPSNACEAVVGVHDVGSHSLGTSLSLQNIMGSPMNTTQLGKSFFQWQVEQEESKLANIPQDQFLARDGDGDTFLHIAVAQGRRALSYVLARKMNALHMLDIKEHNGQSAFQVAVAANQHLIVQDLVNLGAQVNTTDCWGRTPLHVCAEKGHSQVLQAIQKGAVRSNQFVDLEATNYDGLTPLHCAVVAHNAVVHELQRNRQSHSPEVQDLLLRNKSLVDTIKCLIQMGAAVEAKDRKSGRTALHLAAEEANLELIRLFLELPSCLSFVNAKAYNGNTALHVAASLQYRVTQLDAVRLLMRKGADPSTRNLENEQPVHLVPDGPVGEQIRRILKGKSIQQRAPPY
uniprot
proteins
function
FUNCTION: Involved in regulation of NF-kappa-B transcription factor complexes (PubMed:11356851, PubMed:15241416, PubMed:15618216, PubMed:17447895). Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation (PubMed:11356851, PubMed:15241416, PubMed:15618216, PubMed:17447895). Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer (PubMed:11356851, PubMed:15241416, PubMed:15618216, PubMed:17447895). Also seems to activate NF-kappa-B-mediated transcription (PubMed:11356851, PubMed:15241416, PubMed:15618216, PubMed:17447895). In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters (By similarity). Promotes transcription of LCN2 and DEFB4 (By similarity). Is recruited to IL-6 promoters and activates IL-6 but decreases TNF production in response to LPS (PubMed:11086164, PubMed:25107474). Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling (PubMed:11086164, PubMed:25107474). Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (PubMed:25282160). {ECO:0000250|UniProtKB:Q9BYH8, ECO:0000269|PubMed:11086164, ECO:0000269|PubMed:11356851, ECO:0000269|PubMed:15241416, ECO:0000269|PubMed:15618216, ECO:0000269|PubMed:17447895, ECO:0000269|PubMed:25107474, ECO:0000269|PubMed:25282160}.
uniprot
proteins
mass_dalton
79007
uniprot
proteins
mutagenesis
MUTAGEN 163; /note="K->A: Abolishes nuclear localization."; /evidence="ECO:0000269|PubMed:15618216"; MUTAGEN 164; /note="R->A: Abolishes nuclear localization."; /evidence="ECO:0000269|PubMed:15618216"; MUTAGEN 177; /note="K->A: Abolishes nuclear localization."; /evidence="ECO:0000269|PubMed:15618216
uniprot
proteins
pubmed
11086164
uniprot
proteins
pubmed
11278262
uniprot
proteins
pubmed
11356851
uniprot
proteins
pubmed
11797098
uniprot
proteins
pubmed
15241416
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15618216
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17447895
uniprot
proteins
pubmed
25107474
uniprot
proteins
pubmed
25282160
uniprot
proteins
sequence_length
728
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11086164, ECO:0000269|PubMed:11278262, ECO:0000269|PubMed:11356851, ECO:0000269|PubMed:15618216}.
uniprot
proteins