TFPI
entrez
7035
canonical
uniprot
P10646
canonical
ensembl
ENSG00000003436
resolver
ensp
ENSP00000233156
resolver
ensp
ENSP00000342306
resolver
ensp
ENSP00000376172
resolver
ensp
ENSP00000386344
resolver
ensp
ENSP00000567957
resolver
ensp
ENSP00000567972
resolver
ensp
ENSP00000567973
resolver
ensp
ENSP00000567983
resolver
genesymbol
TFPI
resolver
genesymbol_syn
LACI
resolver
genesymbol_syn
TFPI1
resolver
hgnc
HGNC:11760
resolver
uniprot
O95103
resolver
uniprot
Q53TS4
resolver
uniprot_entry
TFPI1_HUMAN
resolver
uniprot_sec
O95103
resolver
uniprot_sec
Q53TS4
resolver
amino_acid_sequence
MIYTMKKVHALWASVCLLLNLAPAPLNADSEEDEEHTIITDTELPPLKLMHSFCAFKADDGPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFESLEECKKMCTRDNANRIIKTTLQQEKPDFCFLEEDPGICRGYITRYFYNNQTKQCERFKYGGCLGNMNNFETLEECKNICEDGPNGFQVDNYGTQLNAVNNSLTPQSTKVPSLFEFHGPSWCLTPADRGLCRANENRFYYNSVIGKCRPFKYSGCGGNENNFTSKQECLRACKKGFIQRISKGGLIKTKRKRKKQRVKIAYEEIFVKNM
uniprot
proteins
function
FUNCTION: Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. {ECO:0000269|PubMed:20676107}.
uniprot
proteins
mass_dalton
35015
uniprot
proteins
mutagenesis
MUTAGEN 49; /note="L->A: Results in resistance to MMP9-mediated cleavage."; /evidence="ECO:0000269|PubMed:20676107"; MUTAGEN 64; /note="K->I: Abolishes inhibition of VII(a)/TF."; MUTAGEN 115; /note="T->F: Results in resistant to ELANE-mediated cleavage. Results in resistant to ELANE- and CTSG-mediated cleavage; when associated with A-117."; /evidence="ECO:0000269|PubMed:20676107"; MUTAGEN 117; /note="L->A: Results in resistant to ELANE- and CTSG-mediated cleavage; when associated with A-115."; /evidence="ECO:0000269|PubMed:20676107"; MUTAGEN 135; /note="R->L: Abolishes inhibition of X(a)."; MUTAGEN 227; /note="R->L: Abolishes inhibition of VII(a)/TF.
uniprot
proteins
post_translational_modification
PTM: O-glycosylated. {ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19017259, ECO:0000269|PubMed:8639592}.
uniprot
proteins
pubmed
10391209
uniprot
proteins
pubmed
11772005
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
19017259
uniprot
proteins
pubmed
1993173
uniprot
proteins
pubmed
2002045
uniprot
proteins
pubmed
20676107
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22144186
uniprot
proteins
pubmed
2271516
uniprot
proteins
pubmed
2452157
uniprot
proteins
pubmed
2553722
uniprot
proteins
pubmed
2781520
uniprot
proteins
pubmed
2927510
uniprot
proteins
pubmed
8639592
uniprot
proteins
pubmed
9199408
uniprot
proteins
pubmed
9242660
uniprot
proteins
sequence_length
304
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform Alpha]: Secreted.; SUBCELLULAR LOCATION: [Isoform Beta]: Microsome membrane {ECO:0000269|PubMed:22144186}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:22144186}.
uniprot
proteins