RAB3C
entrez
115827
canonical
uniprot
Q96E17
canonical
ensembl
ENSG00000152932
resolver
ensp
ENSP00000282878
resolver
enst
ENST00000282878
resolver
genesymbol
RAB3C
resolver
hgnc
HGNC:30269
resolver
uniprot_entry
RAB3C_HUMAN
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs) which prevent Rab-GDP dissociation. {ECO:0000250|UniProtKB:P20336}.
uniprot
proteins
amino_acid_sequence
MRHEAPMQMASAQDARYGQKDSSDQNFDYMFKLLIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKTVFKNEKRIKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWSTQIKTYSWDNAQVILVGNKCDMEDERVISTERGQHLGEQLGFEFFETSAKDNINVKQTFERLVDIICDKMSESLETDPAITAAKQNTRLKETPPPPQPNCAC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. {ECO:0000250|UniProtKB:P10949}.
uniprot
proteins
mass_dalton
25952
uniprot
proteins
mutagenesis
MUTAGEN 94; /note="T->A: Loss of phosphorylation. No effect on GDI2, CHM and CHML binding."; /evidence="ECO:0000269|PubMed:29125462"; MUTAGEN 94; /note="T->E: Phosphomimetic mutant. Loss of GDI2, CHM and CHML binding."; /evidence="ECO:0000269|PubMed:29125462
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Thr-94 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitor GDI2. {ECO:0000269|PubMed:29125462}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
12296628
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
29125462
uniprot
proteins
pubmed
35871249
uniprot
proteins
sequence_length
227
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
uniprot
proteins