Rnaset2b
entrez
68195
canonical
uniprot
C0HKG6
canonical
ensembl
ENSMUSG00000094724
resolver
ensembl
ENSMUSG00000095687
resolver
ensembl
ENSMUSG00000116876
resolver
ensembl
ENSMUSG00000116988
resolver
ensp
ENSMUSP00000086519
resolver
ensp
ENSMUSP00000095031
resolver
ensp
ENSMUSP00000137303
resolver
ensp
ENSMUSP00000156083
resolver
ensp
ENSMUSP00000156290
resolver
ensp
ENSMUSP00000156372
resolver
enst
ENSMUST00000089119
resolver
enst
ENSMUST00000097420
resolver
enst
ENSMUST00000179728
resolver
enst
ENSMUST00000231550
resolver
enst
ENSMUST00000231927
resolver
enst
ENSMUST00000232307
resolver
genesymbol
Rnaset2b
resolver
uniprot
Q5FWA0
resolver
uniprot
Q9CQ01
resolver
uniprot_entry
Q5FWA0_MOUSE
resolver
uniprot_entry
RNT2B_MOUSE
resolver
uniprot_sec
Q9CQ01
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by Zn(2+) and Cu(2+). {ECO:0000250|UniProtKB:O00584}.
uniprot
proteins
amino_acid_sequence
MAPAEARGALPGWISVLGWGLALCSLCGAGPLWSGSHEWKKLILTQHWPPTVCKEVNSCQDSLDYWTIHGLWPDRAEDCNQSWHFNLDEIKDLLRDMKIYWPDVIHRSSNRSQFWKHEWVKHGTCAAQVDALNSEKKYFGKSLDLYKQIDLNSVLQKFGIKPSINYYQLADFKDALTRIYGVVPKIQCLMPEQGESVQTVGQIELCFTKEDLHLRNCTEPGEQLSSRQEAWLAMEASTHGMMVCEDGPIFYPPPTKTQH
uniprot
proteins
ec_number
4.6.1.19
uniprot
proteins
function
FUNCTION: Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8. Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides. In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8. In plasmacytoid dendritic cells, it cooperates with PLD3 or PLD4 5'->3' exonucleases to process RNA fragments and release 2',3'-cyclic guanosine monophosphate (2',3'-cGMP), a potent stimulatory ligand for TLR7. Also plays a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria. Participates as well in degradation of mitochondrion-associated cytosolic rRNAs. {ECO:0000250|UniProtKB:O00584}.
uniprot
proteins
mass_dalton
29609
uniprot
proteins
protein_family
RNase T2 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
259
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:O00584}. Lysosome lumen {ECO:0000250|UniProtKB:O00584}. Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:O00584}. Mitochondrion intermembrane space {ECO:0000250|UniProtKB:O00584}.
uniprot
proteins