Pyroxd1
entrez
297708
canonical
uniprot
Q68FS6
canonical
ensembl
ENSRNOG00000012472
resolver
ensp
ENSRNOP00000083610
resolver
genesymbol
Pyroxd1
resolver
uniprot_entry
PYRD1_RAT
resolver
amino_acid_sequence
MEAARPAGTFVVVGGGIAGVTCAEQLAINFPAEDILLVTASPVIKAVTNFKQVSKVLEEFDVEEQPSTMLENRFPNIKVIESGVKQLKSDKHCIFTEDGREYVYKKLCLCAGAKPKLICEGNPYVLGIRDTDSAQEFQKQLTKARRIMIVGNGGIALELAYEVEVCEVIWAIKDKAIGNTFFDAGAAEFLTSRLLSEKSEAKLAHKRTIYTVEEAKKETSTKSKADYVGSALGPDWHGGLALKGTEEFSHSIHIETKCEVKKIYLQEEFKIMKKKSLAFPKDHHKSVTVDKEMWPVYVELTNGSIYGCDFLVSATGVTPNVQPFLHGNDFDLGEDGGLRVDEQMRTSLPDIYAAGDICTACWPPSPVWQQMRLWTQARQMGCYAAKCMAAATMGHPIDMDFSFELFAHVTKFFNYKVVLLGKYNAQGLGVDHELMLRCTRGQEYIKVVMHNGRMMGAVLIGETDLEETFENLILNQMDLSSYGEDLLNPDIDIEDYFD
uniprot
proteins
ec_number
1.6.99.1
uniprot
proteins
function
FUNCTION: Flavoprotein whose role is to protect RTCB, the catalytic subunit of the tRNA ligase complex (tRNA-LC) involved in tRNA splicing and unfolded protein response, from oxidative inactivation. It directly binds and shields the catalytic center of RTCB, prior to guanylylation, when it is inactive and its active site is vulnerable to oxidation under aerobic conditions. The interaction of PYROXD1 with RTCB is allosterically regulated by NAD(P)H binding and reduction of its FAD cofactor, while reoxidation of PYROXD1 thanks to its NADPH dehydrogenase activity triggers the timed release of RTCB, enabling its subsequent activation. Thereby, this protective mechanism may also function as a molecular timer, regulating RTCB activation through controlled release. {ECO:0000250|UniProtKB:Q8WU10}.
uniprot
proteins
mass_dalton
55490
uniprot
proteins
protein_family
Class-I pyridine nucleotide-disulfide oxidoreductase family
uniprot
proteins
protein_family
PYROXD1 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
498
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8WU10}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8WU10}. Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:Q8WU10}.
uniprot
proteins