Pde2a
entrez
207728
canonical
uniprot
Q922S4
canonical
ensembl
ENSMUSG00000030653
resolver
ensembl
ENSMUSG00000110195
resolver
ensp
ENSMUSP00000081956
resolver
ensp
ENSMUSP00000131553
resolver
ensp
ENSMUSP00000147553
resolver
ensp
ENSMUSP00000147847
resolver
enst
ENSMUST00000209537
resolver
enst
ENSMUST00000211368
resolver
genesymbol
Pde2a
resolver
uniprot
A0A1B0GRJ9
resolver
uniprot
A0A1B0GS94
resolver
uniprot
Q3TCR8
resolver
uniprot
Q3TXZ6
resolver
uniprot
Q3TYK5
resolver
uniprot
Q3TYU3
resolver
uniprot
Q5PR72
resolver
uniprot
Q8K2U1
resolver
uniprot_entry
A0A1B0GRJ9_MOUSE
resolver
uniprot_entry
A0A1B0GS94_MOUSE
resolver
uniprot_entry
PDE2A_MOUSE
resolver
uniprot_entry
Q3TYK5_MOUSE
resolver
uniprot_entry
Q3TYU3_MOUSE
resolver
uniprot_entry
Q5PR72_MOUSE
resolver
uniprot_sec
Q3TCR8
resolver
uniprot_sec
Q3TXZ6
resolver
uniprot_sec
Q8K2U1
resolver
activity_regulation
ACTIVITY REGULATION: The 3',5'-cyclic-AMP phosphodiesterase activity is stimulated by 3',5'-cyclic GMP (By similarity). Specifically inhibited by Bay 60-7550 (PubMed:28463107). {ECO:0000250|UniProtKB:O00408, ECO:0000269|PubMed:28463107}.
uniprot
proteins
amino_acid_sequence
MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPQPCADSLQDALLSLGAVIDIAGLRQAARDALSAVLPKVETVYTYLLDGESRLVCEDPPHELPQEGKIREAVISQKRLSCNGLGPSDLLGKPLARLVAPLAPDMQVLVIPLLDKETGSVAAVILVHCGQLSDSEEQSLQVVEKHALVALRRVQALQQRRPEAVQNTSVDASEDQKDEKGYTDHDRKILQLCGELFDLDATSLQLKVLQYLQQETQATHCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTMGRLGQVVEDKQCIQLKDLTSDDVQQLQNMLGCELQAMLCVPVISRATDQVVALACAFNKLGGDFPTSSFTDEDEHVIQHCFHYTGTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFANFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELSNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNRQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPVNGCCSLEG
uniprot
proteins
ec_number
3.1.4.17
uniprot
proteins
function
FUNCTION: cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:21724846). Has a higher efficiency with cGMP compared to cAMP (By similarity). Plays a role in cell growth and migration (By similarity). {ECO:0000250|UniProtKB:O00408, ECO:0000269|PubMed:21724846}.; FUNCTION: [Isoform PDE2A2]: Regulates mitochondrial cAMP levels and respiration (PubMed:21724846). Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L (PubMed:28463107). {ECO:0000269|PubMed:21724846, ECO:0000269|PubMed:28463107}.
uniprot
proteins
mass_dalton
105619
uniprot
proteins
protein_family
Cyclic nucleotide phosphodiesterase family
uniprot
proteins
protein_family
PDE2 subfamily
uniprot
proteins
pubmed
12271124
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21724846
uniprot
proteins
pubmed
28463107
uniprot
proteins
sequence_length
939
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform PDE2A1]: Cytoplasm {ECO:0000250|UniProtKB:O00408}.; SUBCELLULAR LOCATION: [Isoform PDE2A2]: Mitochondrion matrix {ECO:0000269|PubMed:21724846}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:O00408}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:O00408}.; SUBCELLULAR LOCATION: [Isoform PDE2A3]: Cell membrane {ECO:0000250|UniProtKB:O00408}; Lipid-anchor {ECO:0000250|UniProtKB:O00408}.
uniprot
proteins