Slc34a3
entrez
142681
canonical
uniprot
Q80SU6
canonical
ensembl
ENSMUSG00000006469
resolver
ensp
ENSMUSP00000006638
resolver
enst
ENSMUST00000006638
resolver
genesymbol
Slc34a3
resolver
genesymbol_syn
Npt2c
resolver
uniprot
Q05AC3
resolver
uniprot_entry
NPT2C_MOUSE
resolver
uniprot_sec
Q05AC3
resolver
amino_acid_sequence
MPNSLAGGQVPNPTLDAFDLVDRSLRNAGISGSIPGLEEGGTDPWTFSPLKNADQLKEVGMASRLRRVVSSFLKACGLLGSLYFFICSLDILSSAFQLLGSKMAGDIFKDNVVLSNPVAGLVIGVLVTVLVQSSSTSSSIVVSMVASKLLTVQVSVPIIMGVNVGTSITSTLVSMAQSGDRDEFQRAFSGSAVHGIFNWLTVLVLLPLESATAALERLSELALGAASLQPGQQAPDILKALTRPFTHLIIQLDSSVITSGITSNTTNSSLIKHWCGFRGETPQGSSEGCGLFSSCTERNSSASPEEDRLLCHHLFAGSKLTDLAVGFILLAGSLLVLCVCLVLIVKLLNSVLKGRIAQAVKTVINADFPFPFGWLSGYLAILVGAGLTFLLQSSSVFTAAIVPLMGVGVIDLERAYPLFLGSNIGTTTTALLAALASPADMLIFAVQVALIHFFFNLAGILLWYLVPVLRLPIPLAKRFGNLTAQYRWVAIVYLLLTFLLLPLAAFGLSLAGGTVLAAVGGPLVGLVLLIILVNVLQQHRPSWLPRCLQSWAWLPLWLHSLEPWDRLVTACCPCRACSNSPMTSKVAHCYENPQVIASQQL
uniprot
proteins
function
FUNCTION: Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (PubMed:12690469, PubMed:16113079). The cotransport has a Na(+):Pi stoichiometry of 2:1 and is electroneutral (PubMed:16113079). {ECO:0000269|PubMed:12690469, ECO:0000269|PubMed:16113079}.
uniprot
proteins
mass_dalton
63939
uniprot
proteins
mutagenesis
MUTAGEN 189..191; /note="SGS->AGA: Change of cotransport Na(+):Pi stoichiometry to 3:1; when associated with D-195."; /evidence="ECO:0000269|PubMed:16113079"; MUTAGEN 195; /note="G->D: Change of cotransport Na(+):Pi stoichiometry to 3:1; when associated with 189-AGA-191."; /evidence="ECO:0000269|PubMed:16113079
uniprot
proteins
protein_family
SLC34A transporter family
uniprot
proteins
pubmed
12690469
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16113079
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
601
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:12690469}; Multi-pass membrane protein {ECO:0000255}. Note=Localized at the brush border membrane in the kidney. {ECO:0000269|PubMed:12690469}.
uniprot
proteins
transmembrane_region
TRANSMEM 76..96; /note="Helical; Name=M1"; /evidence="ECO:0000255"; TRANSMEM 111..131; /note="Helical; Name=M2"; /evidence="ECO:0000255"; TRANSMEM 188..208; /note="Helical; Name=M3"; /evidence="ECO:0000255"; TRANSMEM 325..345; /note="Helical; Name=M4"; /evidence="ECO:0000255"; TRANSMEM 370..390; /note="Helical; Name=M5"; /evidence="ECO:0000255"; TRANSMEM 442..462; /note="Helical; Name=M6"; /evidence="ECO:0000255"; TRANSMEM 488..508; /note="Helical; Name=M7"; /evidence="ECO:0000255"; TRANSMEM 513..533; /note="Helical; Name=M8"; /evidence="ECO:0000255
uniprot
proteins