TRMT2A
entrez
27037
canonical
uniprot
Q8IZ69
canonical
ensembl
ENSG00000099899
resolver
ensp
ENSP00000252136
resolver
ensp
ENSP00000384968
resolver
ensp
ENSP00000385807
resolver
ensp
ENSP00000395738
resolver
enst
ENST00000439169
resolver
genesymbol
TRMT2A
resolver
hgnc
HGNC:24974
resolver
uniprot
D3DX25
resolver
uniprot
F2Z2W7
resolver
uniprot
Q32P57
resolver
uniprot
Q96ME6
resolver
uniprot
Q9H732
resolver
uniprot_entry
F2Z2W7_HUMAN
resolver
uniprot_entry
TRM2A_HUMAN
resolver
uniprot_sec
D3DX25
resolver
uniprot_sec
Q32P57
resolver
uniprot_sec
Q96ME6
resolver
uniprot_sec
Q9H732
resolver
amino_acid_sequence
MSENLDNEGPKPMESCGQESSSALSCPTVSVPPAAPAALEEVEKEGAGAATGPGPQPGLYSYIRDDLFTSEIFKLELQNVPRHASFSDVRRFLGRFGLQPHKTKLFGQPPCAFVTFRSAAERDKALRVLHGALWKGRPLSVRLARPKADPMARRRRQEGESEPPVTRVADVVTPLWTVPYAEQLERKQLECEQVLQKLAKEIGSTNRALLPWLLEQRHKHNKACCPLEGVRPSPQQTEYRNKCEFLVGVGVDGEDNTVGCRLGKYKGGTCAVAAPFDTVHIPEATKQVVKAFQEFIRSTPYSAYDPETYTGHWKQLTVRTSRRHQAMAIAYFHPQKLSPEELAELKTSLAQHFTAGPGRASGVTCLYFVEEGQRKTPSQEGLPLEHVAGDRCIHEDLLGLTFRISPHAFFQVNTPAAEVLYTVIQDWAQLDAGSMVLDVCCGTGTIGLALARKVKRVIGVELCPEAVEDARVNAQDNELSNVEFHCGRAEDLVPTLVSRLASQHLVAILDPPRAGLHSKVILAIRRAKNLRRLLYVSCNPRAAMGNFVDLCRAPSNRVKGIPFRPVKAVAVDLFPQTPHCEMLILFERVEHPNGTGVLGPHSPPAQPTPGPPDNTLQETGTFPSS
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
ec_number
2.1.1.35
uniprot
proteins
function
FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine in tRNAs and some mRNAs (PubMed:31361898, PubMed:33799331, PubMed:34556860). Mainly catalyzes the methylation of uridine at position 54 (m5U54) in cytosolic tRNAs (PubMed:31361898, PubMed:33799331). Also able to mediate the formation of 5-methyl-uridine in some mRNAs (PubMed:34123281). {ECO:0000269|PubMed:31361898, ECO:0000269|PubMed:33799331, ECO:0000269|PubMed:34123281, ECO:0000269|PubMed:34556860}.
uniprot
proteins
mass_dalton
68726
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
RNA M5U methyltransferase family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
31361898
uniprot
proteins
pubmed
33799331
uniprot
proteins
pubmed
34123281
uniprot
proteins
pubmed
34556860
uniprot
proteins
sequence_length
625
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305|PubMed:31361898}.
uniprot
proteins