Ptcra
entrez
19208
canonical
uniprot
P0C6B2
canonical
ensembl
ENSMUSG00000036858
resolver
ensp
ENSMUSP00000035683
resolver
enst
ENSMUST00000041012
resolver
genesymbol
Ptcra
resolver
uniprot
A0A0R4J0F4
resolver
uniprot_entry
A0A0R4J0F4_MOUSE
resolver
uniprot_entry
PTCRA_MOUSE
resolver
amino_acid_sequence
MARTWLLLLLGVRCQALPSGIAGTPFPSLAPPITLLVDGRQHMLVVCLVLDAAPPGLDNPVWFSAGNGSALDAFTYGPSLAPDGTWTSLAQLSLPSEELEAWEPLVCHTRPGAGGQNRSTHPLQLSGESSTARSCFPEPLGGTQRQVLWLSLLRLLLFKLLLLDVLLTCSHLRLHVLAGQHLQPPPSRKSLPPTHRIWT
uniprot
proteins
function
FUNCTION: Component of the pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) that plays a crucial role in early T-cell development, particularly alpha-beta T cell differentiation (PubMed:9647201, PubMed:7596413). Isoform 1 acts to retain most TCRB intracellularly, while isoform 2 permits higher levels of cell surface TCRB expression and facilitates signaling from the CD3-TCRB complex. {ECO:0000269|PubMed:7596413, ECO:0000269|PubMed:9647201}.
uniprot
proteins
mass_dalton
21491
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7596413
uniprot
proteins
pubmed
7672822
uniprot
proteins
pubmed
7973703
uniprot
proteins
pubmed
9647201
uniprot
proteins
sequence_length
199
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Cell membrane {ECO:0000250|UniProtKB:Q6ISU1}.
uniprot
proteins
transmembrane_region
TRANSMEM 147..167; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins