Arf1
entrez
11840
canonical
uniprot
P84078
canonical
ensembl
ENSMUSG00000048076
resolver
ensp
ENSMUSP00000079905
resolver
ensp
ENSMUSP00000126120
resolver
enst
ENSMUST00000061242
resolver
enst
ENSMUST00000163300
resolver
genesymbol
Arf1
resolver
uniprot
P10947
resolver
uniprot
P32889
resolver
uniprot
Q3THZ2
resolver
uniprot
Q3U849
resolver
uniprot
Q3UDG1
resolver
uniprot
Q3UF76
resolver
uniprot_entry
ARF1_MOUSE
resolver
uniprot_sec
P10947
resolver
uniprot_sec
P32889
resolver
uniprot_sec
Q3THZ2
resolver
uniprot_sec
Q3U849
resolver
uniprot_sec
Q3UDG1
resolver
uniprot_sec
Q3UF76
resolver
activity_regulation
ACTIVITY REGULATION: Alternates between an inactive GDP-bound form and an active GTP-bound form (By similarity). Activated by guanine nucleotide-exchange factors (GEFs) and inactivated by GTPase-activating proteins (GAPs) (By similarity). {ECO:0000250|UniProtKB:P84077}.
uniprot
proteins
amino_acid_sequence
MGNIFANLFKGLFGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVNEAREELMRMLAEDELRDAVLLVFANKQDLPNAMNAAEITDKLGLHSLRHRNWYIQATCATSGDGLYEGLDWLSNQLRNQK
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Small GTPase involved in protein trafficking between different compartments (PubMed:11950392). Modulates vesicle budding and uncoating within the Golgi complex (By similarity). In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane (By similarity). The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (By similarity). The GTP-bound form interacts with PICK1 to limit PICK1-mediated inhibition of Arp2/3 complex activity; the function is linked to AMPA receptor (AMPAR) trafficking, regulation of synaptic plasticity of excitatory synapses and spine shrinkage during long-term depression (LTD) (By similarity). Plays a key role in the regulation of intestinal stem cells and gut microbiota, and is essential for maintaining intestinal homeostasis (PubMed:36566324). Also plays a critical role in mast cell expansion but not in mast cell maturation by facilitating optimal mTORC1 activation (PubMed:37392777). {ECO:0000250|UniProtKB:P84077, ECO:0000250|UniProtKB:P84079, ECO:0000269|PubMed:11950392, ECO:0000269|PubMed:36566324, ECO:0000269|PubMed:37392777}.
uniprot
proteins
mass_dalton
20697
uniprot
proteins
protein_family
Arf family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
11950392
uniprot
proteins
pubmed
12679809
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17347647
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27723745
uniprot
proteins
pubmed
36566324
uniprot
proteins
pubmed
37392777
uniprot
proteins
pubmed
8947846
uniprot
proteins
sequence_length
181
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:11950392}; Lipid-anchor {ECO:0000250|UniProtKB:P84080}; Cytoplasmic side {ECO:0000305}. Synapse, synaptosome {ECO:0000250|UniProtKB:P84079}. Postsynaptic density {ECO:0000250|UniProtKB:P84079}. Note=In the GDP-bound form, associates transiently with the membranes via its myristoylated N-terminus where guanine nucleotide-exchange factor (GEF)-mediated nucleotide exchange occurs (By similarity). Following nucleotide exchange, the GTP-bound form undergoes a conformational change, leading to the exposure of a myristoylated N-terminal amphipathic helix that provides stable membrane anchorage (By similarity). {ECO:0000250|UniProtKB:P84080}.
uniprot
proteins