Lrrc34
entrez
71827
canonical
uniprot
Q9DAM1
canonical
ensembl
ENSMUSG00000027702
resolver
ensp
ENSMUSP00000029252
resolver
enst
ENSMUST00000029252
resolver
genesymbol
Lrrc34
resolver
genesymbol_syn
Spata34
resolver
uniprot
A0AUN5
resolver
uniprot
Q14B04
resolver
uniprot_entry
LRC34_MOUSE
resolver
uniprot_sec
A0AUN5
resolver
uniprot_sec
Q14B04
resolver
amino_acid_sequence
MEKLQAQYCYLCSENIRKTNPFILNILQKLDEEIEKRPKEKFTVNIAGNNRLDSGQRITGEDFWLLSKTLRNQPCISGVDVRYNLIGDVGAFYAAKLLQKQPSITYLNLMFNDIGPEGGELIAKALHKNKTLKYLRMTGNKIENTGGMLFAAMLQMNSSLEKLDLGDCDLGLQCVIAFSTVLTQNQAIKGINLNRPILYGEQEESTVHIGHMLKENHVLVELHMCKHGMKNYGLQQLCNALYLNSSLRYLDVSCNKITRDGMVFLADVLKSNTTLEVLDLSFNRIETAGAKYLSETLTSHNRSLKALSVVSNKIEGEGLVALSQSMKTNLVLSNIYIWGNKFDEDTCVAYSDLIKSGRLKPDNTDVEPYMVDEHIYLSEVSNGLKRHYYWAPTYGETYMPSSSAGFALVPVGEHL
uniprot
proteins
function
FUNCTION: Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro. {ECO:0000269|PubMed:24991885}.
uniprot
proteins
mass_dalton
46635
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24435972
uniprot
proteins
pubmed
24991885
uniprot
proteins
sequence_length
415
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24435972, ECO:0000269|PubMed:24991885}. Nucleus, nucleolus {ECO:0000269|PubMed:24991885}. Cytoplasm {ECO:0000269|PubMed:24435972, ECO:0000269|PubMed:24991885}. Note=As stem cells differentiate, translocates from the nucleolus to the nucleus and then to the cytoplasm. Colocalizes with NPM1 and NCL in the nucleolus. {ECO:0000269|PubMed:24991885}.
uniprot
proteins