G2e3
entrez
217558
canonical
uniprot
Q5RJY2
canonical
ensembl
ENSMUSG00000035293
resolver
ensp
ENSMUSP00000054474
resolver
ensp
ENSMUSP00000113191
resolver
ensp
ENSMUSP00000113270
resolver
enst
ENSMUST00000054308
resolver
enst
ENSMUST00000119211
resolver
enst
ENSMUST00000121521
resolver
genesymbol
G2e3
resolver
genesymbol_syn
Kiaa1333
resolver
uniprot
E9Q7C2
resolver
uniprot
E9Q7E5
resolver
uniprot
E9QK24
resolver
uniprot
Q6ZPT7
resolver
uniprot
Q8BNA4
resolver
uniprot_entry
E9Q7C2_MOUSE
resolver
uniprot_entry
E9Q7E5_MOUSE
resolver
uniprot_entry
G2E3_MOUSE
resolver
uniprot_sec
E9QK24
resolver
uniprot_sec
Q6ZPT7
resolver
uniprot_sec
Q8BNA4
resolver
amino_acid_sequence
MNENKPDNSQSLACVFCRKNDDCPNKYGEKKTYEKWNFSVHYYCLLMSSGIWQRGKEEEGVYGFLIEDIRKEVQRASKLKCTVCKKNGASIGCVVPTCKRSYHLPCGLQKECIFQFTDNFASFCWKHRPVQAITSNKYSSSLPCTICLEFVEPIPTYNILQSPCCKNAWFHRDCLQVQAINAGVFFFRCTLCNNTDIFQKEMLRMGIHIPEKDASWELEENAYQELLQSHDRCDIRRCHCKKGRDYNEPNSKWEVKRCQSCGSSGTHLACSSLQSWEQNWECLDCRRITYTSDFQKAPKHPLANSTNVTVTDCLLEESSSKLPRQSTVAQHKELLRQGSKFRRDISTILIELGFQIKKKTKTLYINKANVWRSALEQFQSQKFNPSCSIDVVYVNGNEVGSQHLGSKQEFLSHLMHHLENSSVFEGSLAKNLSLNSQAVKENLYYEVGKMLAISLVHGGPSPGFFSETLFNCLAYGPENTLPTLDDVSDIDVAQIIIKIDSATDLNILNSVISQHYNYLEVSGCLRLTTSLSDKFMLVKDILFYHVINRVKAPFESFKQGLKTLGVLEKIQTYPEAFYKILCHKPENLSAKNLSDLFTIHSVADVQTLRFWNSYLKAIEDGKSATTMEDILIFATGCSSVPPTGFKPSLSVECLHVDFPVADKYRNHLVLPATNTYEEFQENMDFTIRDTLRLEKEERSHILPRTLNVSSNEEMLI
uniprot
proteins
ec_number
2.3.2.26
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase involved in the establishment of constitutive heterochromatin at pericentric regions by catalyzing histone H3 'Lys-14' monoubiquitination (H3K14ub). H3K14ub represents a specific tag for heterochromatin formation by facilitating the deposition of histone H3 trimethylated at 'Lys-9' (H3K9me3). Highly expressed in G2/M phase and associates with mitotic chromosomes in an RNA-dependent manner to catalyze H3K14ub, thereby promoting recruitment of SUV39H (SUV39H1 and/or SUV39H2) and subsequent recruitment of HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. {ECO:0000250|UniProtKB:Q7L622}.
uniprot
proteins
mass_dalton
81784
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:18511420}.
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18511420
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
716
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7L622}. Chromosome {ECO:0000250|UniProtKB:Q7L622}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q7L622}. Cytoplasm {ECO:0000250|UniProtKB:Q7L622}. Note=Shuttles between the nucleus and the cytoplasm. In the nucleus, delocalizes from the nucleolus to the nucleoplasm in response to DNA damage. Associates with mitotic chromosomes; enriched at pericentromeric heterochromatin. {ECO:0000250|UniProtKB:Q7L622}.
uniprot
proteins