SMU1
entrez
55234
canonical
uniprot
Q2TAY7
canonical
ensembl
ENSG00000122692
resolver
ensp
ENSP00000380336
resolver
ensp
ENSP00000556468
resolver
genesymbol
SMU1
resolver
hgnc
HGNC:18247
resolver
uniprot
A0MNN4
resolver
uniprot
A8MXW4
resolver
uniprot
B4E3L0
resolver
uniprot
Q9BU59
resolver
uniprot
Q9HA96
resolver
uniprot
Q9NVD1
resolver
uniprot_entry
A0MNN4_HUMAN
resolver
uniprot_entry
SMU1_HUMAN
resolver
uniprot_sec
A8MXW4
resolver
uniprot_sec
B4E3L0
resolver
uniprot_sec
Q9BU59
resolver
uniprot_sec
Q9HA96
resolver
uniprot_sec
Q9NVD1
resolver
amino_acid_sequence
MSIEIESSDVIRLIMQYLKENSLHRALATLQEETTVSLNTVDSIESFVADINSGHWDTVLQAIQSLKLPDKTLIDLYEQVVLELIELRELGAARSLLRQTDPMIMLKQTQPERYIHLENLLARSYFDPREAYPDGSSKEKRRAAIAQALAGEVSVVPPSRLMALLGQALKWQQHQGLLPPGMTIDLFRGKAAVKDVEEEKFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNLIATYSEDGLLKLWKP
uniprot
proteins
function
FUNCTION: Involved in pre-mRNA splicing as a component of the spliceosome (PubMed:28781166). Regulates alternative splicing of the HSPG2 pre-mRNA (By similarity). Required for normal accumulation of IK (PubMed:24945353). Required for normal mitotic spindle assembly and normal progress through mitosis (By similarity). {ECO:0000250|UniProtKB:Q76B40, ECO:0000269|PubMed:24945353, ECO:0000269|PubMed:28781166, ECO:0000305}.; FUNCTION: (Microbial infection) Required, together with IK, for normal splicing of influenza A virus NS1 pre-mRNA, which is required for the production of the exportin NS2 and for the production of influenza A virus particles. Not required for the production of VSV virus particles. {ECO:0000269|PubMed:24945353}.
uniprot
proteins
mass_dalton
57544
uniprot
proteins
protein_family
WD repeat SMU1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15878348
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22365833
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24945353
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28781166
uniprot
proteins
sequence_length
513
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99M63}. Nucleus {ECO:0000269|PubMed:24945353, ECO:0000269|PubMed:28781166}. Nucleus speckle {ECO:0000250|UniProtKB:Q76B40}. Note=Colocalizes with SRSF1 in nuclear speckles. {ECO:0000250|UniProtKB:Q76B40}.
uniprot
proteins