Ssbp1
entrez
381760
canonical
uniprot
Q9CYR0
canonical
ensembl
ENSMUSG00000029911
resolver
ensp
ENSMUSP00000031971
resolver
ensp
ENSMUSP00000110427
resolver
ensp
ENSMUSP00000113563
resolver
ensp
ENSMUSP00000114082
resolver
ensp
ENSMUSP00000273465
resolver
enst
ENSMUST00000031971
resolver
enst
ENSMUST00000114779
resolver
enst
ENSMUST00000117411
resolver
enst
ENSMUST00000121360
resolver
genesymbol
Ssbp1
resolver
uniprot
F7DBD7
resolver
uniprot
Q8R2K3
resolver
uniprot_entry
F7DBD7_MOUSE
resolver
uniprot_entry
Q8R2K3_MOUSE
resolver
uniprot_entry
SSBP_MOUSE
resolver
amino_acid_sequence
MFRRPVLQVFRQFVRHESEVASSLVLERSLNRVQLLGRVGQDPVMRQVEGKNPVTIFSLATNEMWRSGDSEVYQMGDVSQKTTWHRISVFRPGLRDVAYQYVKKGARIFVEGKVDYGEYMDKNNVRRQATTIIAGKKLVVHSVSGCSLEGLA
uniprot
proteins
function
FUNCTION: Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays a crucial role during mtDNA replication by stimulating the activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK. May also function in mtDNA repair. {ECO:0000250|UniProtKB:Q04837}.
uniprot
proteins
mass_dalton
17319
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
31298765
uniprot
proteins
sequence_length
152
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:31298765}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000269|PubMed:31298765}.
uniprot
proteins