ME2
entrez
4200
canonical
uniprot
P23368
canonical
ensembl
ENSG00000082212
resolver
ensp
ENSP00000321070
resolver
ensp
ENSP00000372384
resolver
genesymbol
ME2
resolver
hgnc
HGNC:6984
resolver
uniprot
B2R8J2
resolver
uniprot
Q9BWL6
resolver
uniprot
Q9BYG1
resolver
uniprot
Q9H4B2
resolver
uniprot_entry
MAOM_HUMAN
resolver
uniprot_sec
B2R8J2
resolver
uniprot_sec
Q9BWL6
resolver
uniprot_sec
Q9BYG1
resolver
uniprot_sec
Q9H4B2
resolver
activity_regulation
ACTIVITY REGULATION: Subject to allosteric activation by fumarate. {ECO:0000269|PubMed:12121650, ECO:0000269|PubMed:12962632}.
uniprot
proteins
amino_acid_sequence
MLSRLRVVSTTCTLACRHLHIKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFHRNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLACSQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGLGDLGVYGMGIPVGKLCLYTACAGIRPDRCLPVCIDVGTDNIALLKDPFYMGLYQKRDRTQQYDDLIDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLRKYREKYCTFNDDIQGTAAVALAGLLAAQKVISKPISEHKILFLGAGEAALGIANLIVMSMVENGLSEQEAQKKIWMFDKYGLLVKGRKAKIDSYQEPFTHSAPESIPDTFEDAVNILKPSTIIGVAGAGRLFTPDVIRAMASINERPVIFALSNPTAQAECTAEEAYTLTEGRCLFASGSPFGPVKLTDGRVFTPGQGNNVYIFPGVALAVILCNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANIQEVSINIAIKVTEYLYANKMAFRYPEPEDKAKYVKERTWRSEYDSLLPDVYEWPESASSPPVITE
uniprot
proteins
ec_number
1.1.1.38
uniprot
proteins
function
FUNCTION: NAD-dependent mitochondrial malic enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate. {ECO:0000269|PubMed:12121650, ECO:0000269|PubMed:1993674}.
uniprot
proteins
mass_dalton
65444
uniprot
proteins
mutagenesis
MUTAGEN 67; /note="R->S: Abolishes activation by fumarate."; /evidence="ECO:0000269|PubMed:12121650"; MUTAGEN 91; /note="R->T: Abolishes activation by fumarate."; /evidence="ECO:0000269|PubMed:12121650
uniprot
proteins
protein_family
Malic enzymes family
uniprot
proteins
pubmed
10467136
uniprot
proteins
pubmed
10700286
uniprot
proteins
pubmed
11401430
uniprot
proteins
pubmed
12121650
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
12962632
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
1993674
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
584
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:1993674}.
uniprot
proteins