Klb
entrez
83379
canonical
uniprot
Q99N32
canonical
ensembl
ENSMUSG00000029195
resolver
ensp
ENSMUSP00000031096
resolver
genesymbol
Klb
resolver
genesymbol_syn
Betakl
resolver
uniprot
B2RQN8
resolver
uniprot
Q920J2
resolver
uniprot
Q99N31
resolver
uniprot_entry
KLOTB_MOUSE
resolver
uniprot_sec
B2RQN8
resolver
uniprot_sec
Q920J2
resolver
uniprot_sec
Q99N31
resolver
amino_acid_sequence
MKTGCAAGSPGNEWIFFSSDERNTRSRKTMSNRALQRSAVLSAFVLLRAVTGFSGDGKAIWDKKQYVSPVNPSQLFLYDTFPKNFSWGVGTGAFQVEGSWKTDGRGPSIWDRYVYSHLRGVNGTDRSTDSYIFLEKDLLALDFLGVSFYQFSISWPRLFPNGTVAAVNAQGLRYYRALLDSLVLRNIEPIVTLYHWDLPLTLQEEYGGWKNATMIDLFNDYATYCFQTFGDRVKYWITIHNPYLVAWHGFGTGMHAPGEKGNLTAVYTVGHNLIKAHSKVWHNYDKNFRPHQKGWLSITLGSHWIEPNRTDNMEDVINCQHSMSSVLGWFANPIHGDGDYPEFMKTGAMIPEFSEAEKEEVRGTADFFAFSFGPNNFRPSNTVVKMGQNVSLNLRQVLNWIKLEYDDPQILISENGWFTDSYIKTEDTTAIYMMKNFLNQVLQAIKFDEIRVFGYTAWTLLDGFEWQDAYTTRRGLFYVDFNSEQKERKPKSSAHYYKQIIQDNGFPLKESTPDMKGRFPCDFSWGVTESVLKPEFTVSSPQFTDPHLYVWNVTGNRLLYRVEGVRLKTRPSQCTDYVSIKKRVEMLAKMKVTHYQFALDWTSILPTGNLSKVNRQVLRYYRCVVSEGLKLGVFPMVTLYHPTHSHLGLPLPLLSSGGWLNMNTAKAFQDYAELCFRELGDLVKLWITINEPNRLSDMYNRTSNDTYRAAHNLMIAHAQVWHLYDRQYRPVQHGAVSLSLHCDWAEPANPFVDSHWKAAERFLQFEIAWFADPLFKTGDYPSVMKEYIASKNQRGLSSSVLPRFTAKESRLVKGTVDFYALNHFTTRFVIHKQLNTNRSVADRDVQFLQDITRLSSPSRLAVTPWGVRKLLAWIRRNYRDRDIYITANGIDDLALEDDQIRKYYLEKYVQEALKAYLIDKVKIKGYYAFKLTEEKSKPRFGFFTSDFRAKSSVQFYSKLISSSGLPAENRSPACGQPAEDTDCTICSFLVEKKPLIFFGCCFISTLAVLLSITVFHHQKRRKFQKARNLQNIPLKKGHSRVFS
uniprot
proteins
function
FUNCTION: Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21. {ECO:0000269|PubMed:16075061, ECO:0000269|PubMed:17452648}.
uniprot
proteins
mass_dalton
120189
uniprot
proteins
protein_family
Glycosyl hydrolase 1 family
uniprot
proteins
protein_family
Klotho subfamily
uniprot
proteins
pubmed
11044614
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16075061
uniprot
proteins
pubmed
17452648
uniprot
proteins
sequence_length
1043
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 995..1015; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins