Chmp3
entrez
66700
canonical
uniprot
Q9CQ10
canonical
ensembl
ENSMUSG00000053119
resolver
ensp
ENSMUSP00000068410
resolver
ensp
ENSMUSP00000109815
resolver
enst
ENSMUST00000059462
resolver
enst
ENSMUST00000065364
resolver
genesymbol
Chmp3
resolver
genesymbol_syn
Vps24
resolver
uniprot
Q9D2Z2
resolver
uniprot
Q9D7A5
resolver
uniprot_entry
CHMP3_MOUSE
resolver
uniprot_sec
Q9D2Z2
resolver
uniprot_sec
Q9D7A5
resolver
amino_acid_sequence
MGLFGKTQEKPPKELVNEWSLKIRKEMRVVDRQIRDIQREEEKVKRSVKDAAKKGQKEVCVVLAKEMIRSRKAVSKLYASKAHMNSVLMGMKNQLAVLRVAGSLQKSTEVMKAMQSLVKIPEIQATMRELSKEMMKAGIIEEMLEDTFESMDDQEEMEEAAEMEIDRILFEITAGALGKAPSKVTDALPEPEPAGAMAASEEGEEEEDEEDLEAMQSRLATLRS
uniprot
proteins
function
FUNCTION: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Selectively binds to phosphatidylinositol 3,5-bisphosphate PtdIns(3,5)P2 and PtdIns(3,4)P2 in preference to other phosphoinositides tested. Involved in late stages of cytokinesis. Plays a role in endosomal sorting/trafficking of EGF receptor (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
25219
uniprot
proteins
protein_family
SNF7 family
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17331679
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
224
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Endosome {ECO:0000250}. Late endosome membrane {ECO:0000250}. Note=Localizes to the midbody of dividing cells. {ECO:0000250}.
uniprot
proteins