KPNB1
entrez
3837
canonical
uniprot
Q14974
canonical
ensembl
ENSG00000108424
resolver
ensp
ENSP00000290158
resolver
ensp
ENSP00000438964
resolver
genesymbol
KPNB1
resolver
genesymbol_syn
NTF97
resolver
hgnc
HGNC:6400
resolver
uniprot
B7Z752
resolver
uniprot
B7ZAV6
resolver
uniprot
D3DTT3
resolver
uniprot
Q14637
resolver
uniprot
Q53XN2
resolver
uniprot
Q96J27
resolver
uniprot_entry
B7Z752_HUMAN
resolver
uniprot_entry
IMB1_HUMAN
resolver
uniprot_sec
B7ZAV6
resolver
uniprot_sec
D3DTT3
resolver
uniprot_sec
Q14637
resolver
uniprot_sec
Q53XN2
resolver
uniprot_sec
Q96J27
resolver
amino_acid_sequence
MELITILEKTVSPDRLELEAAQKFLERAAVENLPTFLVELSRVLANPGNSQVARVAAGLQIKNSLTSKDPDIKAQYQQRWLAIDANARREVKNYVLQTLGTETYRPSSASQCVAGIACAEIPVNQWPELIPQLVANVTNPNSTEHMKESTLEAIGYICQDIDPEQLQDKSNEILTAIIQGMRKEEPSNNVKLAATNALLNSLEFTKANFDKESERHFIMQVVCEATQCPDTRVRVAALQNLVKIMSLYYQYMETYMGPALFAITIEAMKSDIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAFGCILEGPEPSQLKPLVIQAMPTLIELMKDPSVVVRDTAAWTVGRICELLPEAAINDVYLAPLLQCLIEGLSAEPRVASNVCWAFSSLAEAAYEAADVADDQEEPATYCLSSSFELIVQKLLETTDRPDGHQNNLRSSAYESLMEIVKNSAKDCYPAVQKTTLVIMERLQQVLQMESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDALQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGGEFLKYMEAFKPFLGIGLKNYAEYQVCLAAVGLVGDLCRALQSNIIPFCDEVMQLLLENLGNENVHRSVKPQILSVFGDIALAIGGEFKKYLEVVLNTLQQASQAQVDKSDYDMVDYLNELRESCLEAYTGIVQGLKGDQENVHPDVMLVQPRVEFILSFIDHIAGDEDHTDGVVACAAGLIGDLCTAFGKDVLKLVEARPMIHELLTEGRRSKTNKAKTLATWATKELRKLKNQA
uniprot
proteins
function
FUNCTION: Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). Acting autonomously, serves itself as NLS receptor (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:24699649, PubMed:7615630, PubMed:9687515). Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607, PubMed:9687515). In association with IPO7, mediates the nuclear import of H1 histone (PubMed:10228156). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones (By similarity). Imports MRTFA, SNAI1 and PRKCI into the nucleus (PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649). {ECO:0000250|UniProtKB:P70168, ECO:0000269|PubMed:10228156, ECO:0000269|PubMed:11682607, ECO:0000269|PubMed:11891849, ECO:0000269|PubMed:19386897, ECO:0000269|PubMed:20818336, ECO:0000269|PubMed:24699649, ECO:0000269|PubMed:7615630, ECO:0000269|PubMed:9687515}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. {ECO:0000269|PubMed:16704975, ECO:0000269|PubMed:9405152, ECO:0000269|PubMed:9891055}.
uniprot
proteins
mass_dalton
97170
uniprot
proteins
mutagenesis
MUTAGEN 178; /note="I->A: Largely reduced binding to FxFG repeats and reduced nuclear import."; /evidence="ECO:0000269|PubMed:10929717"; MUTAGEN 178; /note="I->F,D: Loss of binding to FxFG repeats and reduced nuclear import."; /evidence="ECO:0000269|PubMed:10929717
uniprot
proteins
post_translational_modification
PTM: Mono-ADP-ribosylated by PARP16. {ECO:0000269|PubMed:22701565}.
uniprot
proteins
protein_family
Importin beta family
uniprot
proteins
protein_family
Importin beta-1 subfamily
uniprot
proteins
pubmed
10209022
uniprot
proteins
pubmed
10228156
uniprot
proteins
pubmed
10353244
uniprot
proteins
pubmed
10367892
uniprot
proteins
pubmed
10929717
uniprot
proteins
pubmed
11229403
uniprot
proteins
pubmed
11682607
uniprot
proteins
pubmed
11891849
uniprot
proteins
pubmed
12095920
uniprot
proteins
pubmed
12504010
uniprot
proteins
pubmed
12764225
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15297880
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15629770
uniprot
proteins
pubmed
15836774
uniprot
proteins
pubmed
16171404
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16704975
uniprot
proteins
pubmed
17209048
uniprot
proteins
pubmed
18187419
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19386897
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20147401
uniprot
proteins
pubmed
20476751
uniprot
proteins
pubmed
20701745
uniprot
proteins
pubmed
20818336
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22084111
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22500989
uniprot
proteins
pubmed
22701565
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24699649
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
7615630
uniprot
proteins
pubmed
7627554
uniprot
proteins
pubmed
8617227
uniprot
proteins
pubmed
8692944
uniprot
proteins
pubmed
9405152
uniprot
proteins
pubmed
9670026
uniprot
proteins
pubmed
9687515
uniprot
proteins
pubmed
9891055
uniprot
proteins
pubmed
9891056
uniprot
proteins
sequence_length
876
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11891849}. Nucleus envelope {ECO:0000269|PubMed:11891849}.
uniprot
proteins