Mob1b
entrez
68473
canonical
uniprot
Q8BPB0
canonical
ensembl
ENSMUSG00000006262
resolver
ensp
ENSMUSP00000006424
resolver
enst
ENSMUST00000006424
resolver
genesymbol
Mob1b
resolver
genesymbol_syn
Mobkl1a
resolver
uniprot
Q3T9U1
resolver
uniprot_entry
MOB1B_MOUSE
resolver
uniprot_entry
Q3T9U1_MOUSE
resolver
amino_acid_sequence
MSFLFGSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRMAVMLPEGEDLNEWVAVNTVDFFNQINMLYGTITDFCTEESCPVMSAGPKYEYHWADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDPVIQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLTSKDR
uniprot
proteins
function
FUNCTION: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
25091
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1. {ECO:0000250}.
uniprot
proteins
protein_family
MOB1/phocein family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
216
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
uniprot
proteins