Trpc3
entrez
60395
canonical
uniprot
Q9JMI9
canonical
ensembl
ENSRNOG00000016070
resolver
ensembl
ENSRNOG00055002115
resolver
ensembl
ENSRNOG00060007574
resolver
ensembl
ENSRNOG00065008675
resolver
ensp
ENSRNOP00000046270
resolver
ensp
ENSRNOP00000095733
resolver
ensp
ENSRNOP00055002530
resolver
ensp
ENSRNOP00060009485
resolver
ensp
ENSRNOP00065010224
resolver
enst
ENSRNOT00000046700
resolver
enst
ENSRNOT00000109104
resolver
enst
ENSRNOT00055003385
resolver
enst
ENSRNOT00060012517
resolver
enst
ENSRNOT00065013775
resolver
genesymbol
Trpc3
resolver
genesymbol_syn
Trrp3
resolver
uniprot
A0A8I6B383
resolver
uniprot
F1LNQ7
resolver
uniprot_entry
A0A8I6B383_RAT
resolver
uniprot_entry
TRPC3_RAT
resolver
uniprot_sec
F1LNQ7
resolver
activity_regulation
ACTIVITY REGULATION: Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Activated by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May be activated by internal calcium store depletion. Inhibited by intracellular Ca(2+). {ECO:0000250|UniProtKB:Q13507}.
uniprot
proteins
amino_acid_sequence
MSTKVKKCREPARVTLPAPEEEDGEAEGAEPQRRRRGWRGVNGGLEPPCPRAPPSPGPDASSEGSPSRWRTAGMRDKGRRQAVRGPAFMFGARGPSLTAEEERFLDAAEYGNIPVVRKMLEESRTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILGHPGFAASRRLTLSPCEQELRDDDFYAYDEDGTRFSPDITPIILAAHCHKYEVVHLLLLKGARIERPHDYFCRCADCAEKQRLDAFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESVEPLERHGHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVIDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYIVQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSHVQESDLSEVTLPPEVQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFLAFMIGMFILYSYYLGAKVNPAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRITNFSKCRRRRLQKDLELGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKLNPSALRCE
uniprot
proteins
function
FUNCTION: Forms a receptor-activated non-selective calcium permeant cation channel. May be operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G protein coupled receptors. {ECO:0000250|UniProtKB:Q13507}.
uniprot
proteins
mass_dalton
103499
uniprot
proteins
protein_family
STrpC subfamily
uniprot
proteins
protein_family
TRPC3 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
pubmed
10984475
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
909
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q13507}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 448..465; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13507"; TRANSMEM 497..515; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13507"; TRANSMEM 529..550; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13507"; TRANSMEM 595..618; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13507"; TRANSMEM 638..661; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13507"; TRANSMEM 702..727; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13507
uniprot
proteins