Dhrs4
entrez
266686
canonical
uniprot
Q8VID1
canonical
ensembl
ENSRNOG00000018239
resolver
ensembl
ENSRNOG00055012440
resolver
ensembl
ENSRNOG00060026632
resolver
ensembl
ENSRNOG00065032870
resolver
ensp
ENSRNOP00000024782
resolver
ensp
ENSRNOP00055017149
resolver
ensp
ENSRNOP00060038354
resolver
ensp
ENSRNOP00065046492
resolver
enst
ENSRNOT00000024782
resolver
enst
ENSRNOT00055021208
resolver
enst
ENSRNOT00060046172
resolver
enst
ENSRNOT00065056513
resolver
genesymbol
Dhrs4
resolver
uniprot
Q6IRD4
resolver
uniprot_entry
DHRS4_RAT
resolver
uniprot_sec
Q6IRD4
resolver
amino_acid_sequence
MQKAGLLLRGWTRAWKSVRMASSGLTRQNPLANKVALVTASTDGIGLAIARRLAEDGAHVVISSRKQQNVDRAVATLQGEGLSVTGVVCHVGKAEDREKLVNMALKLHQGIDILVSNAAVNPFFGNLMDVTEEVWNKVLSINVTASAMMIKAVVPAMEKRGGGSVVIVSSVAGFVLFPSLGPYNVSKTALLGLTKNFAAELAPKNIRVNCLAPGLIKTHFSSVLWKEKAREEMIKETMQIRRLGKPEDCVGIVSFLCSEDASYINGETVVVGGGTPSRL
uniprot
proteins
ec_number
1.1.1.184
uniprot
proteins
ec_number
1.1.1.300
uniprot
proteins
function
FUNCTION: NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones. Reduces all-trans-retinal and 9-cis retinal. Reduces 3-ketosteroids and benzil into 3alpha-hydroxysteroids and S-benzoin, respectively, in contrast to the stereoselectivity of primates DHRS4s which produce 3beta-hydroxysteroids and R-benzoin. In the reverse reaction, catalyzes the NADP-dependent oxidation of 3alpha-hydroxysteroids and alcohol, but with much lower efficiency. Involved in the metabolism of 3alpha-hydroxysteroids, retinoid, isatin and xenobiotic carbonyl compounds. {ECO:0000250|UniProtKB:Q8WNV7}.
uniprot
proteins
mass_dalton
29822
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
279
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome {ECO:0000250|UniProtKB:Q8WNV7}.
uniprot
proteins