SPCS2
entrez
9789
canonical
uniprot
Q15005
canonical
ensembl
ENSG00000118363
resolver
ensp
ENSP00000263672
resolver
enst
ENST00000263672
resolver
genesymbol
SPCS2
resolver
genesymbol_syn
KIAA0102
resolver
genesymbol_syn
SPC25
resolver
hgnc
HGNC:28962
resolver
uniprot
Q15507
resolver
uniprot
Q3KQT0
resolver
uniprot
Q641R4
resolver
uniprot
Q6FG65
resolver
uniprot
Q6IRX0
resolver
uniprot
Q6P1P4
resolver
uniprot
Q96HU9
resolver
uniprot_entry
SPCS2_HUMAN
resolver
uniprot_sec
Q15507
resolver
uniprot_sec
Q3KQT0
resolver
uniprot_sec
Q641R4
resolver
uniprot_sec
Q6FG65
resolver
uniprot_sec
Q6IRX0
resolver
uniprot_sec
Q6P1P4
resolver
uniprot_sec
Q96HU9
resolver
amino_acid_sequence
MAAAAVQGGRSGGSGGCSGAGGASNCGTGSGRSGLLDKWKIDDKPVKIDKWDGSAVKNSLDDSAKKVLLEKYKYVENFGLIDGRLTICTISCFFAIVALIWDYMHPFPESKPVLALCVISYFVMMGILTIYTSYKEKSIFLVAHRKDPTGMDPDDIWQLSSSLKRFDDKYTLKLTFISGRTKQQREAEFTKSIAKFFDHSGTLVMDAYEPEISRLHDSLAIERKIK
uniprot
proteins
function
FUNCTION: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369). Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity). {ECO:0000250|UniProtKB:Q04969, ECO:0000269|PubMed:34388369}.
uniprot
proteins
mass_dalton
25003
uniprot
proteins
protein_family
SPCS2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
34388369
uniprot
proteins
pubmed
7788527
uniprot
proteins
sequence_length
226
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q28250}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q28250}.
uniprot
proteins
transmembrane_region
TRANSMEM 87..107; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 112..132; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins