Q9WVL4
uniprot
Q9WVL4
canonical
activity_regulation
ACTIVITY REGULATION: Inhibited by RCVRN, which prevents the interaction between GRK1 and RHO (By similarity). Inhibition is calcium-dependent (By similarity). {ECO:0000250|UniProtKB:P28327}.
uniprot
proteins
amino_acid_sequence
MDFGSLETVVANSAFIAARGSFDGSSTPSSRDKKYLAKLRLPPLSKCEGLRDNLSLEFESLCSEQPIGKRLFQQFLKTDERHVPALELWKDIEDYDTADDDLRPQKAQAILAEYLDPQGTLFCNFLDQGMVTRVKEGPTGSQDGLFQPLLQATMEHLSQAPFQEYLESLYFLRFLQWKWLEAQPIGEDWFLDFRVLGKGGFGEVSACQMKATGKMYACKKLNKKRLKKKKGYQGAIVEKRILTKVHSRFIVSLAYAFETKTDLCLVMTIMNGGDVRYHIYNVDEDNPGFSEPRAIYYTAQIISGLEHLHQRRIVYRDLKPENVLLDNDGNIRISDLGLAVELKEGQNKTKGYAGTPGFMAPELLRGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRIISEPVKYPEKFSQASKDFCEQLLEKDPEKRLGFRDGTCDALRANVLFKDISWRQLEAGMLIPPFIPDSRTVYAKNIQDVGAFSTVKGVVFDKADTEFFQEFASGNCSIPWQEEMIETGLFGDLNVWRADGQMPDDMKGITTEEAAPTAKSGMCLIS
uniprot
proteins
ec_number
2.7.11.14
uniprot
proteins
function
FUNCTION: Retina-specific kinase involved in the regulation of phototransduction, playing a key role in terminating the light-activated rhodopsin (RHO) signal in rod photoreceptors. Following light activation, it phosphorylates RHO thereby promoting binding of S-arrestin (SAG) which then blocks transducin-mediated opsin signaling (PubMed:10097103, PubMed:10704496, PubMed:26427409). This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (PubMed:10097103, PubMed:10704496). May play a role in the maintenance of the outer nuclear layer in the retina (PubMed:26427409). {ECO:0000250|UniProtKB:P28327, ECO:0000269|PubMed:10097103, ECO:0000269|PubMed:10704496, ECO:0000269|PubMed:26427409}.
uniprot
proteins
mass_dalton
63837
uniprot
proteins
mutagenesis
MUTAGEN 363; /note="L->P: Defects in photoreceptor light response and loss of photoreceptors by one year of age."; /evidence="ECO:0000269|PubMed:26427409
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated, Ser-21 is a minor site of autophosphorylation compared to Ser-491 and Thr-492. Phosphorylation at Ser-21 is regulated by light and activated by cAMP. {ECO:0000250}.; PTM: Farnesylation is required for full activity. {ECO:0000250|UniProtKB:P28327}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
GPRK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10097103
uniprot
proteins
pubmed
10704496
uniprot
proteins
pubmed
11717351
uniprot
proteins
pubmed
15961391
uniprot
proteins
pubmed
21504899
uniprot
proteins
pubmed
26427409
uniprot
proteins
sequence_length
564
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P28327}; Lipid-anchor {ECO:0000250|UniProtKB:P28327}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:15961391}. Note=Subcellular location is not affected by light or dark conditions. {ECO:0000269|PubMed:15961391}.
uniprot
proteins