PICK1
entrez
9463
canonical
uniprot
Q9NRD5
canonical
ensembl
ENSG00000100151
resolver
ensp
ENSP00000349465
resolver
ensp
ENSP00000385205
resolver
ensp
ENSP00000553362
resolver
ensp
ENSP00000553363
resolver
ensp
ENSP00000553365
resolver
ensp
ENSP00000621484
resolver
genesymbol
PICK1
resolver
genesymbol_syn
PRKCABP
resolver
hgnc
HGNC:9394
resolver
uniprot
B3KS52
resolver
uniprot
O95906
resolver
uniprot_entry
PICK1_HUMAN
resolver
uniprot_sec
B3KS52
resolver
uniprot_sec
O95906
resolver
amino_acid_sequence
MFADLDYDIEEDKLGIPTVPGKVTLQKDAQNLIGISIGGGAQYCPCLYIVQVFDNTPAALDGTVAAGDEITGVNGRSIKGKTKVEVAKMIQEVKGEVTIHYNKLQADPKQGMSLDIVLKKVKHRLVENMSSGTADALGLSRAILCNDGLVKRLEELERTAELYKGMTEHTKNLLRAFYELSQTHRAFGDVFSVIGVREPQPAASEAFVKFADAHRSIEKFGIRLLKTIKPMLTDLNTYLNKAIPDTRLTIKKYLDVKFEYLSYCLKVKEMDDEEYSCIALGEPLYRVSTGNYEYRLILRCRQEARARFSQMRKDVLEKMELLDQKHVQDIVFQLQRLVSTMSKYYNDCYAVLRDADVFPIEVDLAHTTLAYGLNQEEFTDGEEEEEEEDTAAGEPSRDTRGAAGPLDKGGSWCDS
uniprot
proteins
function
FUNCTION: Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. {ECO:0000269|PubMed:20403402}.
uniprot
proteins
mass_dalton
46600
uniprot
proteins
mutagenesis
MUTAGEN 27..28; /note="KD->AA: Abolishes interaction with other proteins, but not with itself."; /evidence="ECO:0000269|PubMed:10623590, ECO:0000269|PubMed:11343649, ECO:0000269|PubMed:11802773"; MUTAGEN 27; /note="K->E: Abolishes interaction with GRIA2, but not with PRKCA."; /evidence="ECO:0000269|PubMed:15247289
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors. {ECO:0000269|PubMed:20403402}.; PTM: Palmitoylation on Cys-413 is essential for long-term synaptic depression (LTD). {ECO:0000250}.
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
10623590
uniprot
proteins
pubmed
11343649
uniprot
proteins
pubmed
11641419
uniprot
proteins
pubmed
11802773
uniprot
proteins
pubmed
12529303
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15247289
uniprot
proteins
pubmed
15304526
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17384233
uniprot
proteins
pubmed
20403402
uniprot
proteins
sequence_length
415
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9EP80}. Membrane {ECO:0000250|UniProtKB:Q9EP80}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9EP80}. Membrane {ECO:0000250|UniProtKB:Q62083}; Lipid-anchor {ECO:0000250|UniProtKB:Q62083}. Postsynaptic density {ECO:0000250|UniProtKB:Q9EP80}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q9EP80}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9EP80}. Note=Also membrane-associated, present at excitatory synapses. {ECO:0000250|UniProtKB:Q9EP80}.
uniprot
proteins