Drc1
entrez
381738
canonical
uniprot
Q3USS3
canonical
ensembl
ENSMUSG00000073102
resolver
ensp
ENSMUSP00000098992
resolver
ensp
ENSMUSP00000188545
resolver
enst
ENSMUST00000101448
resolver
genesymbol
Drc1
resolver
genesymbol_syn
Ccdc164
resolver
genesymbol_syn
Gm1060
resolver
uniprot
B9EKF0
resolver
uniprot_entry
DRC1_MOUSE
resolver
uniprot_sec
B9EKF0
resolver
amino_acid_sequence
MNPSGTIGVLEQNGEEHLATPILGPSVHSDNPQERIQARRLRIAARQEARRREALGEYLDGKKESEEEQSKSYKQKEESRLKLTKLLLCGTELVTNIQVAADVREIHRRVEEEETKRQRLEKLENEVKTSQDKFDEITAKWEEGRRKRIPQELWEMLNSQQVHCAELIEDKNKLANELQQELKIKDDQYVKDLKKQSEDITLILERMEEQVKNVMKNFRQELIHIEKAFESERQELLSSNKKKWERALQAHNAKELEYLTNRMKKVEDYEKQLNKQRVWDCEEYNTIKIKLEQDVQILEQQLQQMKATYQLNQEKLEYNFQVLKKRDEESTVIKSQQKRKLNRLHDVVNNLRTKYTKQIRQFQDDNQSLTSDYKRLVTQFKDLQKALRHFIIIDEEKFREIWLMNEAEAKELAQRAFDVDRIIHSQHLGLPWNMPDLWFLNNVGPISLQQQKSVTQILEELLLQTEDEATEAAMSEDEDYMDLPNQISAKTTTKVLMLLCDESGFLIESKLLSLLHPLEKSECYLLRLDAIFSALAIEDEDDLYKLVNFFLRYRAHRLSSAQASSSIHSNVERTSLMSALERLSLMSQTDKGSMVSKSDQEPTEQEDEQEGDNASLSSRELEEQEDLSSPRFIHPNDVLKILEAFVTGLKKPKDAQPVLKLKKETRDNSKDTEYWESLAAVIPFFKQNLWDALYKALEKYYLVLTERAKLLMENESLEQQNAEMQSLLQQYLQAKVNTELQIPPTQGFRMPSK
uniprot
proteins
function
FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes (PubMed:34169321). Coassembles with DRC2 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules. {ECO:0000250|UniProtKB:P0DL09, ECO:0000250|UniProtKB:Q96MC2, ECO:0000269|PubMed:34169321}.
uniprot
proteins
mass_dalton
88507
uniprot
proteins
mutagenesis
MUTAGEN 244..753; /note="Missing: Loss of DRC1 in spermatozoa of homozygous mice. Sperm flagella have a disorganized axoneme and lack N-DRC, radial spokes and dynein arms."; /evidence="ECO:0000269|PubMed:34169321"; MUTAGEN 554..753; /note="Missing: Loss of DRC1 in spermatozoa of homozygous mice. Sperm flagella have a disorganized axoneme and lack N-DRC, radial spokes and dynein arms."; /evidence="ECO:0000269|PubMed:34169321
uniprot
proteins
protein_family
DRC1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23354437
uniprot
proteins
pubmed
34169321
uniprot
proteins
sequence_length
753
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:P0DL09}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:P0DL09}.
uniprot
proteins