Q9JJX6
uniprot
Q9JJX6
canonical
activity_regulation
ACTIVITY REGULATION: Activated by ATP (PubMed:27477609). pH-dependent and inhibited by acidic pH (By similarity). {ECO:0000250|UniProtKB:P51577, ECO:0000269|PubMed:27477609}.
uniprot
proteins
amino_acid_sequence
MAGCCSVLGSFLFEYDTPRIVLIRSRKVGLMNRVVQLLILAYVIGWVFVWEKGYQETDSVVSSVTTKAKGVAVTNTSQLGFRIWDVADYVVPAQEENSLFIMTNMIVTVNQTQGTCPEIPDKTSICDSDANCTLGSSDTHSSGIGTGRCVPFNASVKTCEVAAWCPVENDAGVPTPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTSYLKSCIYNARTDPFCPIFRLGQIVADAGHSFQEMAVEGGIMGIQIKWDCNLDRAASHCLPRYSFRRLDTRDLEHNVSPGYNFRFAKYYRDLAGNEQRTLTKAYGIRFDIIVFGKAGKFDIIPTMINVGSGLALLGVATVLCDVIVLYCMKKRYYYRDKKYKYVEDYEQGLSGEMNQ
uniprot
proteins
function
FUNCTION: ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium. CTP, but not GTP or UTP, functions as a weak affinity agonist for P2RX4 (By similarity). Activated by extracellularly released ATP, it plays multiple role in immunity and central nervous system physiology (PubMed:26456657, PubMed:35119925). Plays a key role in initial steps of T-cell activation and Ca(2+) microdomain formation (PubMed:35119925). Also participates in basal T-cell activity without TCR/CD3 stimulation (PubMed:35119925). Promotes the differentiation and activation of Th17 cells via expression of retinoic acid-related orphan receptor C/RORC (By similarity). Upon activation, drives microglia motility via the PI3K/Akt pathway (PubMed:17299767). Could also function as an ATP-gated cation channel of lysosomal membranes (PubMed:27477609). {ECO:0000250|UniProtKB:P51577, ECO:0000250|UniProtKB:Q99571, ECO:0000269|PubMed:17299767, ECO:0000269|PubMed:26456657, ECO:0000269|PubMed:27477609, ECO:0000269|PubMed:35119925}.
uniprot
proteins
mass_dalton
43438
uniprot
proteins
protein_family
P2X receptor family
uniprot
proteins
pubmed
17299767
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26456657
uniprot
proteins
pubmed
27477609
uniprot
proteins
pubmed
35119925
uniprot
proteins
sequence_length
388
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q99571}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F8W463}. Lysosome membrane {ECO:0000269|PubMed:27477609}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..54; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:F8W463"; TRANSMEM 339..359; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:F8W463
uniprot
proteins