Cd22
entrez
12483
canonical
uniprot
P35329
canonical
ensembl
ENSMUSG00000030577
resolver
ensp
ENSMUSP00000019248
resolver
ensp
ENSMUSP00000139871
resolver
genesymbol
Cd22
resolver
genesymbol_syn
Lyb-8
resolver
genesymbol_syn
Siglec2
resolver
uniprot
Q3UP36
resolver
uniprot
Q9JHL2
resolver
uniprot
Q9JJX9
resolver
uniprot
Q9JJY0
resolver
uniprot
Q9JJY1
resolver
uniprot
Q9R056
resolver
uniprot
Q9R094
resolver
uniprot
Q9WU51
resolver
uniprot_entry
CD22_MOUSE
resolver
uniprot_sec
Q3UP36
resolver
uniprot_sec
Q9JHL2
resolver
uniprot_sec
Q9JJX9
resolver
uniprot_sec
Q9JJY0
resolver
uniprot_sec
Q9JJY1
resolver
uniprot_sec
Q9R056
resolver
uniprot_sec
Q9R094
resolver
uniprot_sec
Q9WU51
resolver
amino_acid_sequence
MRVHYLWLLLILGHVASARYSSANDWTVDHPQTLFAWEGACIRIPCKYKTPLPKARLDNILLFQNYEFDKATKKFTGTVLYNATKTEKDPESELYLSKQGRVTFLGNRIDNCTLKIHPIRANDSGNLGLRMTAGTERWMEPIHLNVSEKPFQPYIQMPSEIRESQSVTLTCGLNFSCFGYDILLKWFLEDSEITSITSSVTSITSSVTSSIKNVYTESKLTFQPKWTDHGKSVKCQVQHSSKVLSERTVRLDVKYTPKLEIKVNPTEVEKNNSVTMTCRVNSSNPKLRTVAVSWFKDGRPLEDQELEQEQQMSKLILHSVTKDMRGKYRCQASNDIGPGESEEVELTVHYAPEPSRVHIYPSPAEEGQSVELICESLASPSATNYTWYHNRKPIPGDTQEKLRIPKVSPWHAGNYSCLAENRLGHGKIDQEAKLDVHYAPKAVTTVIQSFTPILEGDSVTLVCRYNSSNPDVTSYRWNPQGSGSVLKPGVLRIQKVTWDSMPVSCAACNHKCSWALPVILNVHYAPRDVKVLKVSPASEIRAGQRVLLQCDFAESNPAEVRFFWKKNGSLVQEGRYLSFGSVSPEDSGNYNCMVNNSIGETLSQAWNLQVLYAPRRLRVSISPGDHVMEGKKATLSCESDANPPISQYTWFDSSGQDLHSSGQKLRLEPLEVQHTGSYRCKGTNGIGTGESPPSTLTVYYSPETIGKRVALGLGFCLTICILAIWGMKIQKKWKQNRSQQGLQENSSGQSFFVRNKKARRTPLSEGPQSQGCYNPAMDDTVSYAILRFPESDTHNTGDAGTPATQAPPPNNSDSVTYSVIQKRPMGDYENVNPSCPEDESIHYSELVQFGAGKRPQAKEDVDYVTLKH
uniprot
proteins
function
FUNCTION: Most highly expressed siglec (sialic acid-binding immunoglobulin-like lectin) on B-cells that plays a role in various aspects of B-cell biology including differentiation, antigen presentation, and trafficking to bone marrow (PubMed:7533044, PubMed:9016707). Binds to alpha 2,6-linked sialic acid residues of surface molecules such as CD22 itself, CD45 and IgM in a cis configuration. Can also bind to ligands on other cells as an adhesion molecule in a trans configuration. Acts as an inhibitory coreceptor on the surface of B-cells and inhibits B-cell receptor induced signaling, characterized by inhibition of the calcium mobilization and cellular activation (PubMed:9016707). Mechanistically, the immunoreceptor tyrosine-based inhibitory motif domain is phosphorylated by the Src kinase LYN, which in turn leads to the recruitment of the protein tyrosine phosphatase 1/PTPN6, leading to the negative regulation of BCR signaling. If this negative signaling from is of sufficient strength, apoptosis of the B-cell can be induced. {ECO:0000250|UniProtKB:P20273, ECO:0000269|PubMed:7533044, ECO:0000269|PubMed:9016707}.
uniprot
proteins
mass_dalton
97181
uniprot
proteins
mutagenesis
MUTAGEN 828; /note="Y->F: Abolishes binding to GRB2."; /evidence="ECO:0000269|PubMed:10373493
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues by LYN. {ECO:0000269|PubMed:9601638}.; PTM: Phosphorylation of Tyr-783 and Tyr-843 are involved in binding to SYK. Phosphorylation of Tyr-828 is involved in binding to GRB2. Phosphorylation of Tyr-863 is involved in binding to SYK, PLCG2 and PIK3R1/PIK3R2. {ECO:0000269|PubMed:10373493}.
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
protein_family
SIGLEC (sialic acid binding Ig-like lectin) family
uniprot
proteins
pubmed
10373493
uniprot
proteins
pubmed
10501843
uniprot
proteins
pubmed
10748054
uniprot
proteins
pubmed
10975807
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7533044
uniprot
proteins
pubmed
8100843
uniprot
proteins
pubmed
9016707
uniprot
proteins
pubmed
9601638
uniprot
proteins
sequence_length
868
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P20273}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P20273}.
uniprot
proteins
transmembrane_region
TRANSMEM 709..727; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins