CD226
entrez
10666
canonical
uniprot
Q15762
canonical
ensembl
ENSG00000150637
resolver
ensp
ENSP00000280200
resolver
ensp
ENSP00000461947
resolver
ensp
ENSP00000462453
resolver
ensp
ENSP00000463927
resolver
ensp
ENSP00000464084
resolver
ensp
ENSP00000521269
resolver
ensp
ENSP00000521270
resolver
ensp
ENSP00000621283
resolver
enst
ENST00000280200
resolver
enst
ENST00000577287
resolver
enst
ENST00000581982
resolver
enst
ENST00000582621
resolver
enst
ENST00000851210
resolver
enst
ENST00000851211
resolver
enst
ENST00000951224
resolver
genesymbol
CD226
resolver
genesymbol_syn
DNAM1
resolver
hgnc
HGNC:16961
resolver
uniprot
B2R818
resolver
uniprot
J3QR77
resolver
uniprot_entry
CD226_HUMAN
resolver
uniprot_entry
J3QR77_HUMAN
resolver
uniprot_sec
B2R818
resolver
amino_acid_sequence
MDYPTLLLALLHVYRALCEEVLWHTSVPFAENMSLECVYPSMGILTQVEWFKIGTQQDSIAIFSPTHGMVIRKPYAERVYFLNSTMASNNMTLFFRNASEDDVGYYSCSLYTYPQGTWQKVIQVVQSDSFEAAVPSNSHIVSEPGKNVTLTCQPQMTWPVQAVRWEKIQPRQIDLLTYCNLVHGRNFTSKFPRQIVSNCSHGRWSVIVIPDVTVSDSGLYRCYLQASAGENETFVMRLTVAEGKTDNQYTLFVAGGTVLLLLFVISITTIIVIFLNRRRRRERRDLFTESWDTQKAPNNYRSPISTSQPTNQSMDDTREDIYVNYPTFSRRPKTRV
uniprot
proteins
function
FUNCTION: Cell surface receptor that plays an important role in the immune system, particularly in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-cells and NK cells (PubMed:8673704, PubMed:9712030). Functions as a costimulatory receptor upon recognition of target cells, such as virus-infected or tumor cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112 on target cells, promotes the cytotoxic activity of NK cells and CTLs, enhancing their ability to kill these cells (PubMed:26755705, PubMed:31253644, PubMed:30591568). Mechanistically, phosphorylation by Src kinases such as LYN of FYN, enables binding to adapter GRB2, leading to activation of VAV1, PI3K and PLCG1. Promotes also activation of kinases ERK and AKT, as well as calcium fluxes (By similarity). {ECO:0000250|UniProtKB:Q8K4F0, ECO:0000269|PubMed:26755705, ECO:0000269|PubMed:30591568, ECO:0000269|PubMed:31253644, ECO:0000269|PubMed:8673704, ECO:0000269|PubMed:9712030}.
uniprot
proteins
mass_dalton
38614
uniprot
proteins
mutagenesis
MUTAGEN 113; /note="Y->A: Significantly reduced NK-cell killing."; /evidence="ECO:0000269|PubMed:31253644"; MUTAGEN 322; /note="Y->F: No loss of association with lipid rafts."; /evidence="ECO:0000269|PubMed:15684041"; MUTAGEN 329; /note="S->F: Loss of association with lipid rafts and loss of phosphorylation by PKC."; /evidence="ECO:0000269|PubMed:15684041, ECO:0000269|PubMed:9712030
uniprot
proteins
post_translational_modification
PTM: PKC-mediated phosphorylation at Ser-329 is required for lipid raft recruitment (PubMed:15684041). Phosphorylation of Tyr-322 requires association with lipid rafts and allows GRB2 binding and activation of subsequent signaling (By similarity). {ECO:0000250|UniProtKB:Q8K4F0, ECO:0000269|PubMed:15684041}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15039383
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15607800
uniprot
proteins
pubmed
15684041
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
26755705
uniprot
proteins
pubmed
30591568
uniprot
proteins
pubmed
31253644
uniprot
proteins
pubmed
8673704
uniprot
proteins
pubmed
9712030
uniprot
proteins
sequence_length
336
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15684041}; Single-pass type I membrane protein {ECO:0000305}. Note=Localizes to lipid rafts. {ECO:0000269|PubMed:15684041}.
uniprot
proteins
transmembrane_region
TRANSMEM 255..275; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins