Snx6
entrez
72183
canonical
uniprot
Q6P8X1
canonical
ensembl
ENSMUSG00000005656
resolver
ensp
ENSMUSP00000005798
resolver
ensp
ENSMUSP00000194671
resolver
enst
ENSMUST00000005798
resolver
genesymbol
Snx6
resolver
uniprot
Q9CZ03
resolver
uniprot_entry
SNX6_MOUSE
resolver
uniprot_sec
Q9CZ03
resolver
amino_acid_sequence
MMEGLDDGPDFLSEEDRGLKAINVDLQSDAALQVDISDALSERDRVKFTVHTKSSLPNFKQNEFSVVRQHEEFIWLHDSFVENEDYAGYIIPPAPPRPDFDASREKLQKLGEGEGSMTKEEFTKMKQELEAEYLAIFKKTVAMHEVFLCRVAAHPILRKDLNFHVFLEYNQDLSVRGKNKKEKLEDFFKNMVKSADGVIVSGVKDVDDFFEHERTFLLEYHNRVKDASAKSDRMTRSHKSAADDYNRIGSSLYALGTQDSTDICKFFLKVSELFDKTRKIEARVSADEDLKLSDLLKYYLRESQAAKDLLYRRSRSLVDYENANKALDKARAKNKDVLQAETSQQLCCQKFEKISESAKQELIDFKTRRVAAFRKNLVELAELELKHAKGNLQLLQNCLAVLNGDT
uniprot
proteins
function
FUNCTION: Involved in several stages of intracellular trafficking. Interacts with membranes phosphatidylinositol 3,4-bisphosphate and/or phosphatidylinositol 4,5-bisphosphate (Probable). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC). Does not have in vitro vesicle-to-membrane remodeling activity (By similarity). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptor IGF2R. May function as link between transport vesicles and dynactin. Negatively regulates retrograde transport of BACE1 from the cell surface to the trans-Golgi network. Involved in E-cadherin sorting and degradation; inhibits PIP5K1C-mediated E-cadherin degradation (By similarity). In association with GIT1 involved in EGFR degradation (PubMed:18523162). Promotes lysosomal degradation of CDKN1B (PubMed:20228253). May contribute to transcription regulation (By similarity). {ECO:0000250|UniProtKB:Q9UNH7, ECO:0000269|PubMed:18523162, ECO:0000269|PubMed:20228253}.
uniprot
proteins
mass_dalton
46649
uniprot
proteins
post_translational_modification
PTM: In vitro phosphorylated by PIM1; not affecting PIM1-dependent nuclear translocation (By similarity). {ECO:0000250|UniProtKB:Q9UNH7}.
uniprot
proteins
protein_family
Sorting nexin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18523162
uniprot
proteins
pubmed
20228253
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
406
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:20228253}; Peripheral membrane protein {ECO:0000269|PubMed:20228253}; Cytoplasmic side {ECO:0000269|PubMed:20228253}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q9UNH7}. Cytoplasm {ECO:0000250|UniProtKB:Q9UNH7}. Nucleus {ECO:0000250|UniProtKB:Q9UNH7}. Note=Interaction with SNX1 or SNX2 promotes location at endosome membranes (By similarity). Only a minor proportion is seen in the nucleus (By similarity). {ECO:0000250|UniProtKB:Q9UNH7}.
uniprot
proteins