Cyth1
entrez
19157
canonical
uniprot
Q9QX11
canonical
ensembl
ENSMUSG00000017132
resolver
ensp
ENSMUSP00000017276
resolver
ensp
ENSMUSP00000114792
resolver
ensp
ENSMUSP00000341789
resolver
enst
ENSMUST00000151165
resolver
genesymbol
Cyth1
resolver
genesymbol_syn
Pscd1
resolver
genesymbol_syn
mKIAA4240
resolver
uniprot
B1AQE4
resolver
uniprot
O88817
resolver
uniprot
Q3TZ02
resolver
uniprot
Q570Y7
resolver
uniprot
Q76MU4
resolver
uniprot
Q8K3E8
resolver
uniprot_entry
B1AQE4_MOUSE
resolver
uniprot_entry
CYH1_MOUSE
resolver
uniprot_entry
Q3TZ02_MOUSE
resolver
uniprot_entry
Q570Y7_MOUSE
resolver
uniprot_entry
Q8K3E8_MOUSE
resolver
uniprot_sec
O88817
resolver
uniprot_sec
Q76MU4
resolver
amino_acid_sequence
MEDDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKEEIAEVANEIESLGSTEERKNMQRNKQVAMGRKKFNMDPKKGIQFLIENGLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEFSIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNTGVFQSTDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPEEKEDWIKCIKAAISRDPFYEMLAARKKKVSSTKRH
uniprot
proteins
function
FUNCTION: Promotes guanine-nucleotide exchange on ARF1, ARF5 and ARF6 (PubMed:18042453, PubMed:20080746). Promotes the activation of ARF factors through replacement of GDP with GTP (PubMed:18042453). Plays an important role in membrane trafficking, during junctional remodeling and epithelial polarization, through regulation of ARF6 activity (PubMed:20080746, PubMed:29420262). {ECO:0000269|PubMed:18042453, ECO:0000269|PubMed:20080746, ECO:0000269|PubMed:29420262}.
uniprot
proteins
mass_dalton
46274
uniprot
proteins
mutagenesis
MUTAGEN 157; /note="E->K: Impairs epithelium polarity."; /evidence="ECO:0000269|PubMed:20080746"; MUTAGEN 385; /note="L->A: Impairs autoinhibition; when associated with A-389. Impairs translocation to the cell membrane."; /evidence="ECO:0000269|PubMed:18042453"; MUTAGEN 389; /note="K->A: Impairs autoinhibition; when associated with A-385. Impairs translocation to the cell membrane."; /evidence="ECO:0000269|PubMed:18042453"; MUTAGEN 394; /note="S->E: Increases guanine exchange factor activity."; /evidence="ECO:0000269|PubMed:18042453
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by SCF(FBXW11) E3 ubiquitin-protein ligase complex. Ubiquitination induces proteasomal degradation. {ECO:0000269|PubMed:29420262}.
uniprot
proteins
pubmed
10978522
uniprot
proteins
pubmed
18042453
uniprot
proteins
pubmed
20080746
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29420262
uniprot
proteins
pubmed
9744817
uniprot
proteins
pubmed
9745014
uniprot
proteins
sequence_length
398
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18042453, ECO:0000269|PubMed:29420262}; Peripheral membrane protein {ECO:0000269|PubMed:18042453}. Cytoplasm, cytosol {ECO:0000269|PubMed:18042453, ECO:0000269|PubMed:29420262}. Cell junction, tight junction {ECO:0000269|PubMed:20080746}. Cell junction, adherens junction {ECO:0000269|PubMed:20080746}. Note=Colocalized with TJP1 during epithelial polarization (PubMed:20080746). {ECO:0000269|PubMed:20080746}.
uniprot
proteins