ME3
entrez
10873
canonical
uniprot
Q16798
canonical
ensembl
ENSG00000151376
resolver
ensp
ENSP00000315255
resolver
ensp
ENSP00000376998
resolver
ensp
ENSP00000440246
resolver
ensp
ENSP00000545348
resolver
ensp
ENSP00000545349
resolver
ensp
ENSP00000647505
resolver
ensp
ENSP00000703050
resolver
ensp
ENSP00000784584
resolver
enst
ENST00000323418
resolver
genesymbol
ME3
resolver
hgnc
HGNC:6985
resolver
uniprot
B2R995
resolver
uniprot
B7Z6V0
resolver
uniprot
F8W715
resolver
uniprot
Q6TCH8
resolver
uniprot
Q8TBJ0
resolver
uniprot_entry
B2R995_HUMAN
resolver
uniprot_entry
F8W715_HUMAN
resolver
uniprot_entry
MAON_HUMAN
resolver
uniprot_entry
Q6TCH8_HUMAN
resolver
uniprot_sec
B7Z6V0
resolver
uniprot_sec
Q8TBJ0
resolver
activity_regulation
ACTIVITY REGULATION: Is not subjected to allosteric activation by fumarate. {ECO:0000269|PubMed:36590518}.
uniprot
proteins
amino_acid_sequence
MGAALGTGTRLAPWPGRACGALPRWTPTAPAQGCHSKPGPARPVPLKKRGYDVTRNPHLNKGMAFTLEERLQLGIHGLIPPCFLSQDVQLLRIMRYYERQQSDLDKYIILMTLQDRNEKLFYRVLTSDVEKFMPIVYTPTVGLACQHYGLTFRRPRGLFITIHDKGHLATMLNSWPEDNIKAVVVTDGERILGLGDLGCYGMGIPVGKLALYTACGGVNPQQCLPVLLDVGTNNEELLRDPLYIGLKHQRVHGKAYDDLLDEFMQAVTDKFGINCLIQFEDFANANAFRLLNKYRNKYCMFNDDIQGTASVAVAGILAALRITKNKLSNHVFVFQGAGEAAMGIAHLLVMALEKEGVPKAEATRKIWMVDSKGLIVKGRSHLNHEKEMFAQDHPEVNSLEEVVRLVKPTAIIGVAAIAGAFTEQILRDMASFHERPIIFALSNPTSKAECTAEKCYRVTEGRGIFASGSPFKSVTLEDGKTFIPGQGNNAYVFPGVALGVIAGGIRHIPDEIFLLTAEQIAQEVSEQHLSQGRLYPPLSTIRDVSLRIAIKVLDYAYKHNLASYYPEPKDKEAFVRSLVYTPDYDSFTLDSYTWPKEAMNVQTV
uniprot
proteins
ec_number
1.1.1.40
uniprot
proteins
function
FUNCTION: Catalyzes the oxidative decarboxylation of (S)-malate to pyruvate using NADP(+), and is able to reverse the reaction but only with significantly lower efficiency (PubMed:7818469). Can also catalyze the decarboxylation of oxaloacetate into pyruvate (By similarity). {ECO:0000250|UniProtKB:P48163, ECO:0000269|PubMed:7818469}.
uniprot
proteins
mass_dalton
67068
uniprot
proteins
protein_family
Malic enzymes family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
36590518
uniprot
proteins
pubmed
7818469
uniprot
proteins
sequence_length
604
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix.
uniprot
proteins