CDHR5
entrez
53841
canonical
uniprot
Q9HBB8
canonical
ensembl
ENSG00000099834
resolver
ensp
ENSP00000345726
resolver
ensp
ENSP00000351118
resolver
ensp
ENSP00000380676
resolver
ensp
ENSP00000542924
resolver
ensp
ENSP00000654084
resolver
genesymbol
CDHR5
resolver
genesymbol
MUPCDH
resolver
genesymbol_syn
MUCDHL
resolver
genesymbol_syn
MUPCDH
resolver
hgnc
HGNC:7521
resolver
uniprot
B4DV98
resolver
uniprot
C9J7X1
resolver
uniprot
Q58EZ6
resolver
uniprot
Q9H746
resolver
uniprot
Q9HAU3
resolver
uniprot
Q9HBB5
resolver
uniprot
Q9HBB6
resolver
uniprot
Q9HBB7
resolver
uniprot
Q9NX86
resolver
uniprot
Q9NXI9
resolver
uniprot_entry
B4DV98_HUMAN
resolver
uniprot_entry
CDHR5_HUMAN
resolver
uniprot_entry
Q58EZ6_HUMAN
resolver
uniprot_sec
C9J7X1
resolver
uniprot_sec
Q9H746
resolver
uniprot_sec
Q9HAU3
resolver
uniprot_sec
Q9HBB5
resolver
uniprot_sec
Q9HBB6
resolver
uniprot_sec
Q9HBB7
resolver
uniprot_sec
Q9NX86
resolver
uniprot_sec
Q9NXI9
resolver
amino_acid_sequence
MGSWALLWPPLLFTGLLVRPPGTMAQAQYCSVNKDIFEVEENTNVTEPLVDIHVPEGQEVTLGALSTPFAFRIQGNQLFLNVTPDYEEKSLLEAQLLCQSGGTLVTQLRVFVSVLDVNDNAPEFPFKTKEIRVEEDTKVNSTVIPETQLQAEDRDKDDILFYTLQEMTAGASDYFSLVSVNRPALRLDRPLDFYERPNMTFWLLVRDTPGENVEPSHTATATLVLNVVPADLRPPWFLPCTFSDGYVCIQAQYHGAVPTGHILPSPLVLRPGPIYAEDGDRGINQPIIYSIFRGNVNGTFIIHPDSGNLTVARSVPSPMTFLLLVKGQQADLARYSVTQVTVEAVAAAGSPPRFPQRLYRGTVARGAGAGVVVKDAAAPSQPLRIQAQDPEFSDLNSAITYRITNHSHFRMEGEVVLTTTTLAQAGAFYAEVEAHNTVTSGTATTVIEIQVSEQEPPSTDVPPSPEAGGTTGPWTSTTSEVPRPPEPSQGPSTTSSGGGTGPHPPSGTTLRPPTSSTPGGPPGAENSTSHQPATPGGDTAQTPKPGTSQPMPPGVGTSTSHQPATPSGGTAQTPEPGTSQPMPPSMGTSTSHQPATPGGGTAQTPEAGTSQPMPPGMGTSTSHQPTTPGGGTAQTPEPGTSQPMPLSKSTPSSGGGPSEDKRFSVVDMAALGGVLGALLLLALLGLAVLVHKHYGPRLKCCCGKAPEPQPQGFDNQAFLPDHKANWAPVPSPTHDPKPAEAPMPAEPAPPGPASPGGAPEPPAAARAGGSPTAVRSILTKERRPEGGYKAVWFGEDIGTEADVVVLNAPTLDVDGASDSGSGDEGEGAGRGGGPYDAPGGDDSYI
uniprot
proteins
function
FUNCTION: Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation. {ECO:0000269|PubMed:24725409}.
uniprot
proteins
mass_dalton
88223
uniprot
proteins
mutagenesis
MUTAGEN 109; /note="R->G: Loss of binding to CDHR2."; /evidence="ECO:0000269|PubMed:24725409"; MUTAGEN 845; /note="I->R: Loss of interaction with USH1C."; /evidence="ECO:0000269|PubMed:24725409
uniprot
proteins
post_translational_modification
PTM: N- and O-glycosylated. {ECO:0000250|UniProtKB:Q9JIK1}.
uniprot
proteins
pubmed
11031102
uniprot
proteins
pubmed
12167596
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24725409
uniprot
proteins
pubmed
26812018
uniprot
proteins
pubmed
32209652
uniprot
proteins
sequence_length
845
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:24725409}; Single-pass type I membrane protein {ECO:0000269|PubMed:24725409}. Cell projection, microvillus membrane {ECO:0000269|PubMed:24725409, ECO:0000269|PubMed:32209652}; Single-pass type I membrane protein {ECO:0000269|PubMed:24725409}.
uniprot
proteins
transmembrane_region
TRANSMEM 670..690; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins