NCK2
entrez
8440
canonical
uniprot
O43639
canonical
ensembl
ENSG00000071051
resolver
ensp
ENSP00000233154
resolver
ensp
ENSP00000377018
resolver
ensp
ENSP00000410428
resolver
ensp
ENSP00000431109
resolver
ensp
ENSP00000569713
resolver
ensp
ENSP00000569714
resolver
ensp
ENSP00000569715
resolver
ensp
ENSP00000569716
resolver
ensp
ENSP00000569717
resolver
ensp
ENSP00000569718
resolver
ensp
ENSP00000569719
resolver
ensp
ENSP00000569720
resolver
ensp
ENSP00000610695
resolver
ensp
ENSP00000610696
resolver
ensp
ENSP00000610697
resolver
ensp
ENSP00000610698
resolver
ensp
ENSP00000610699
resolver
ensp
ENSP00000610700
resolver
ensp
ENSP00000628333
resolver
ensp
ENSP00000628334
resolver
ensp
ENSP00000628335
resolver
ensp
ENSP00000628336
resolver
ensp
ENSP00000628337
resolver
ensp
ENSP00000628338
resolver
ensp
ENSP00000628340
resolver
ensp
ENSP00000628341
resolver
ensp
ENSP00000628342
resolver
ensp
ENSP00000628343
resolver
ensp
ENSP00000628344
resolver
ensp
ENSP00000628345
resolver
ensp
ENSP00000628346
resolver
ensp
ENSP00000628347
resolver
enst
ENST00000233154
resolver
enst
ENST00000393349
resolver
enst
ENST00000451463
resolver
enst
ENST00000522586
resolver
enst
ENST00000899654
resolver
enst
ENST00000899655
resolver
enst
ENST00000899656
resolver
enst
ENST00000899657
resolver
enst
ENST00000899658
resolver
enst
ENST00000899659
resolver
enst
ENST00000899660
resolver
enst
ENST00000899661
resolver
enst
ENST00000940636
resolver
enst
ENST00000940637
resolver
enst
ENST00000940638
resolver
enst
ENST00000940639
resolver
enst
ENST00000940640
resolver
enst
ENST00000940641
resolver
enst
ENST00000958274
resolver
enst
ENST00000958275
resolver
enst
ENST00000958276
resolver
enst
ENST00000958277
resolver
enst
ENST00000958278
resolver
enst
ENST00000958279
resolver
enst
ENST00000958281
resolver
enst
ENST00000958282
resolver
enst
ENST00000958283
resolver
enst
ENST00000958284
resolver
enst
ENST00000958285
resolver
enst
ENST00000958286
resolver
enst
ENST00000958287
resolver
enst
ENST00000958288
resolver
genesymbol
NCK2
resolver
genesymbol_syn
GRB4
resolver
hgnc
HGNC:7665
resolver
uniprot
A0A0S2Z4L8
resolver
uniprot
A0A0S2Z4M6
resolver
uniprot
D3DVK1
resolver
uniprot
E7ERP6
resolver
uniprot
Q9BWN9
resolver
uniprot
Q9UIC3
resolver
uniprot_entry
A0A0S2Z4L8_HUMAN
resolver
uniprot_entry
A0A0S2Z4M6_HUMAN
resolver
uniprot_entry
E7ERP6_HUMAN
resolver
uniprot_entry
NCK2_HUMAN
resolver
uniprot_sec
D3DVK1
resolver
uniprot_sec
Q9BWN9
resolver
uniprot_sec
Q9UIC3
resolver
amino_acid_sequence
MTEEVIVIAKWDYTAQQDQELDIKKNERLWLLDDSKTWWRVRNAANRTGYVPSNYVERKNSLKKGSLVKNLKDTLGLGKTRRKTSARDASPTPSTDAEYPANGSGADRIYDLNIPAFVKFAYVAEREDELSLVKGSRVTVMEKCSDGWWRGSYNGQIGWFPSNYVLEEVDEAAAESPSFLSLRKGASLSNGQGSRVLHVVQTLYPFSSVTEEELNFEKGETMEVIEKPENDPEWWKCKNARGQVGLVPKNYVVVLSDGPALHPAHAPQISYTGPSSSGRFAGREWYYGNVTRHQAECALNERGVEGDFLIRDSESSPSDFSVSLKASGKNKHFKVQLVDNVYCIGQRRFHTMDELVEHYKKAPIFTSEHGEKLYLVRALQ
uniprot
proteins
function
FUNCTION: Adapter protein which associates with tyrosine-phosphorylated growth factor receptors or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:16835242}.
uniprot
proteins
mass_dalton
42915
uniprot
proteins
mutagenesis
MUTAGEN 148; /note="W->K: Abolishes interaction with DOCK1."; /evidence="ECO:0000269|PubMed:11240126"; MUTAGEN 234; /note="W->K: Abolishes interaction with DOCK1 and IRS1."; /evidence="ECO:0000269|PubMed:11171109, ECO:0000269|PubMed:11240126
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000269|PubMed:10026169}.
uniprot
proteins
pubmed
10026169
uniprot
proteins
pubmed
10330411
uniprot
proteins
pubmed
11171109
uniprot
proteins
pubmed
11240126
uniprot
proteins
pubmed
12470648
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16337946
uniprot
proteins
pubmed
16835242
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19807924
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
9737977
uniprot
proteins
pubmed
9843575
uniprot
proteins
sequence_length
380
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16835242}. Endoplasmic reticulum {ECO:0000269|PubMed:16835242}.
uniprot
proteins