Spz1
entrez
79401
canonical
uniprot
Q99MY0
canonical
ensembl
ENSMUSG00000046957
resolver
ensp
ENSMUSP00000054083
resolver
enst
ENSMUST00000050658
resolver
genesymbol
Spz1
resolver
uniprot
Q3V487
resolver
uniprot
Q80X69
resolver
uniprot_entry
SPZ1_MOUSE
resolver
uniprot_sec
Q3V487
resolver
uniprot_sec
Q80X69
resolver
amino_acid_sequence
MSDTDNSAEMPARCPSPNPAPGAKQEPPNSGITISLLEIGSLPTVCYHSFPPPKNSICPVEKRGRVQKFSNLLKDVKDVLKNIAGVEEKSTVGEPFDDAYIPEDLSELNVRGVEKKNKIRFKDDLFIHFDPEREQNTMKQMLLKNQSAKNMVPKFARDLCNAEETRGFDGMLLSVKRPRNGSLHLRGEYRKLRNNMEQLLQEADHWSKQHNELSELMRSYQECQNETQETTDKDRACLQNQPNNGLSTKQKLEEQVKKLSHDTHALHLIAALLENECQVLQQRVDILKDFHLHEAGLGHEKPLQMSCEQDKKCPKLAEADKTDAFKHTTRATEGTIRKPKILRSPDVCFTKKARNNRFNARVAKKSLVGKRRTVSSFR
uniprot
proteins
function
FUNCTION: Transcription factor that binds to the DNA sequence 5'-CANNTG-3'(E box) and the G-box motif. Directly binds to a guanine-rich region of the PCNA promoter and up-regulates its expression which in turn induces cell transformation and tumor formation. May play an important role in the regulation of cell proliferation and differentiation during spermatogenesis. {ECO:0000269|PubMed:11165476, ECO:0000269|PubMed:14980513, ECO:0000269|PubMed:15899793}.
uniprot
proteins
mass_dalton
43091
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MAPK1/ERK2 and MAPK3/ERK1. {ECO:0000269|PubMed:15899793}.
uniprot
proteins
pubmed
11165476
uniprot
proteins
pubmed
14980513
uniprot
proteins
pubmed
15226296
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15899793
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
378
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15226296}. Nucleus {ECO:0000269|PubMed:11165476, ECO:0000269|PubMed:15226296}.
uniprot
proteins