Trim72
entrez
365377
canonical
uniprot
A0JPQ4
canonical
ensembl
ENSRNOG00000022099
resolver
ensembl
ENSRNOG00055030024
resolver
ensembl
ENSRNOG00060025076
resolver
ensembl
ENSRNOG00065015448
resolver
ensp
ENSRNOP00000030976
resolver
ensp
ENSRNOP00055043004
resolver
ensp
ENSRNOP00060035936
resolver
ensp
ENSRNOP00065020140
resolver
enst
ENSRNOT00000029994
resolver
enst
ENSRNOT00055052068
resolver
enst
ENSRNOT00060043384
resolver
enst
ENSRNOT00065025632
resolver
genesymbol
Trim72
resolver
genesymbol_syn
Mg53
resolver
uniprot_entry
TRI72_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Specifically binds phosphatidylserine (By similarity). The binding to phospholipids enhances ubiquitination activity (By similarity). {ECO:0000250|UniProtKB:Q1XH17}.
uniprot
proteins
amino_acid_sequence
MSTAPGLLRQELSCPLCLQLFDAPVTAECGHSFCRACLIRVAGEPADDGTVACPCCQASTRPQALSTNLQLARLVEGLAQVPQGHCEEHLDPLSIYCEQDRTLVCGVCASLGSHRGHRLLPAAEAHARLKTQLPQQKAQLQEACMRKEKSVAVLEHQLVEVEETVRQFRGAVGEQLGKMRMFLAALESSLDREAERVRGEAGVALRRELSSLNSYLEQLRQMEKVLEEVADKPQTEFLMKFCLVTSRLQKILSESPPPARLDIQLPVISDDFKFQVWKKMFRALMPELEELTFDPSSAHPSLVVSASGRRVECSEQKAPPAGEDTCQFDKTVAVVAKQLLSQGEHYWEVEVGDKPRWALGVMAADASRRGRLHAVPSQGLWLLGLRDGKILEAHVEAKEPRALRTPERPPARIGLYLSFADGVLTFYDASNTDALTPLFSFHERLPGPVYPMFDVCWHDKGKNSQPLLLVGPDSEQA
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Muscle-specific E3 ubiquitin-protein ligase that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites (By similarity). Its ubiquitination activity is mediated by E2 ubiquitin-conjugating enzymes UBE2D1, UBE2D2 and UBE2D3 (By similarity). Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site (By similarity). This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation (By similarity). Probably acts upstream of the Ca(2+)-dependent membrane resealing process (By similarity). Required for transport of DYSF to sites of cell injury during repair patch formation (By similarity). Regulates membrane budding and exocytosis (By similarity). May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity). {ECO:0000250|UniProtKB:Q1XH17}.
uniprot
proteins
mass_dalton
52832
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q1XH17}.
uniprot
proteins
post_translational_modification
PTM: Disulfide bond formation at Cys-242 occurs in case of membrane damage that cause the entry of the oxidized milieu of the extracellular space, resulting in homooligomerization. {ECO:0000250}.; PTM: S-nitrosylation at Cys-144 stabilizes TRIM72 and protects against oxidation-induced protein degradation and cell death. {ECO:0000250|UniProtKB:Q6ZMU5}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
477
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q6ZMU5}. Note=Tethered to plasma membrane and cytoplasmic vesicles via its interaction with phosphatidylserine. {ECO:0000250}.
uniprot
proteins