Hcn1
entrez
84390
canonical
uniprot
Q9JKB0
canonical
ensembl
ENSRNOG00000055382
resolver
ensp
ENSRNOP00000073952
resolver
enst
ENSRNOT00000089218
resolver
genesymbol
Hcn1
resolver
uniprot
F1LSH6
resolver
uniprot_entry
HCN1_RAT
resolver
uniprot_sec
F1LSH6
resolver
activity_regulation
ACTIVITY REGULATION: Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. cAMP binding promotes tetramerization and formation of an active channel. Compared to other family members, cAMP has less stimulatory effect on HCN1 because part of the molecules already contain bound cAMP and form homotetramers when cAMP levels are low, this inherent tetramerization in HCN1 results in a weaker response to increased cAMP (By similarity). {ECO:0000250|UniProtKB:O88704}.
uniprot
proteins
amino_acid_sequence
MEGGGKPNSASNSRDDGNSVYPSKAPATGPAAADKRLGTPPGGGAAGKEHGNSVCFKVDGGGGEEPAGSFEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEKGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILSELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQIVKHDREMVQAIPPINYPQMTALNCTSSTTTPTSRMRTQSPPVYTATSLSHSNLHSPSPSTQTPQPSAILSPCSYTTAVCSPPIQSPLATRTFHYASPTASQLSLMQQPQPQLQQSQVQQTQPQPQPQPQQPQQQQQQQQQQQQQQQQQQQQQQPQTPGSSTPKNEVHKSTQALHNTNLTREVRPLSASQPSLPHEVSTMISRPHPTVGESLASIPQPMATVHSTGLQAGSRSTVPQRVTLFRQMSSGAIPPNRGVPPAPPPPAAVQRESPSVLNKDPDAEKPRFASNL
uniprot
proteins
function
FUNCTION: Hyperpolarization-activated ion channel that are permeable to sodium and potassium ions. Exhibits weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (By similarity). Participates in cerebellar mechanisms of motor learning (By similarity). May mediate responses to sour stimuli (PubMed:11675786). {ECO:0000250|UniProtKB:O60741, ECO:0000250|UniProtKB:O88704, ECO:0000269|PubMed:11675786}.
uniprot
proteins
mass_dalton
101429
uniprot
proteins
protein_family
Potassium channel HCN family
uniprot
proteins
pubmed
11000485
uniprot
proteins
pubmed
11675786
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
902
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11675786}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O60741}.
uniprot
proteins
transmembrane_region
TRANSMEM 132..153; /note="Helical; Name=Segment S1"; /evidence="ECO:0000250|UniProtKB:O60741"; TRANSMEM 163..183; /note="Helical; Name=Segment S2"; /evidence="ECO:0000250|UniProtKB:O60741"; TRANSMEM 205..225; /note="Helical; Name=Segment S3"; /evidence="ECO:0000250|UniProtKB:O60741"; TRANSMEM 250..270; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000250|UniProtKB:O60741"; TRANSMEM 285..307; /note="Helical; Name=Segment S5"; /evidence="ECO:0000250|UniProtKB:O60741"; TRANSMEM 361..381; /note="Helical; Name=Segment S6"; /evidence="ECO:0000250|UniProtKB:O60741
uniprot
proteins