P28042
uniprot
P28042
canonical
amino_acid_sequence
MFRRPVLQVFRQFVRQESEVASSLVLERSLNRVQLLGRVGQDPVMRQVEGKNPVTIFSLATNEMWRSGDNEAYQMGDVSQKTTWHRISVFRPGLRDVAYQYVKKGARIFVEGKVDYGEYMDKNNVRRQATTIIADNIIFLSDQAREKPLNG
uniprot
proteins
function
FUNCTION: Binds preferentially and cooperatively to pyrimidine rich single-stranded DNA (ss-DNA). In vitro, required to maintain the copy number of mitochondrial DNA (mtDNA) and plays a crucial role during mtDNA replication by stimulating the activity of the replisome components POLG and TWNK at the replication fork. Promotes the activity of the gamma complex polymerase POLG, largely by organizing the template DNA and eliminating secondary structures to favor ss-DNA conformations that facilitate POLG activity. In addition it is able to promote the 5'-3' unwinding activity of the mtDNA helicase TWNK. May also function in mtDNA repair. {ECO:0000250|UniProtKB:Q04837}.
uniprot
proteins
mass_dalton
17455
uniprot
proteins
pubmed
2221914
uniprot
proteins
pubmed
8482537
uniprot
proteins
pubmed
9611270
uniprot
proteins
sequence_length
151
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q04837}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250|UniProtKB:Q04837}.
uniprot
proteins