Lsm11
entrez
72290
canonical
uniprot
Q8BUV6
canonical
ensembl
ENSMUSG00000044847
resolver
ensp
ENSMUSP00000057343
resolver
ensp
ENSMUSP00000117531
resolver
enst
ENSMUST00000062458
resolver
enst
ENSMUST00000129820
resolver
genesymbol
Lsm11
resolver
uniprot
Q5SUH5
resolver
uniprot_entry
LSM11_MOUSE
resolver
uniprot_entry
Q5SUH5_MOUSE
resolver
amino_acid_sequence
MEEREWGARSARAGSPASPPSPRLDVSSYSFDPLLALYAPRLPPIPYPNAPCFNNVAEYESFLKGGRTGRGRARGTGEPASAGTSTGTSTGAGSSSRARRRAAPTPDPERIQRLRRLMVVKEDTDGTAGARRQGPGRSKKAPRNVLTRMPLHEGSPLGELHRCIREGVKVNVHIRTFKGLRGVCTGFLVAFDKFWNMALTDVDETYRKPVLGKAYERDSSLTLTRLFDRLKLQDSSKKEADSKSAVEDSTLSRYSQTSTWKVASVWGRGDTDRSSHRRSRSVPSSLQASAREESRSELSGRTTRTEGSSVGGTFSRATTLSRGQSRKKKRKPKVDYQQVFTRHINQIFIRGENVLLVHLAQ
uniprot
proteins
function
FUNCTION: Component of the U7 snRNP complex that is involved in the histone 3'-end pre-mRNA processing (PubMed:12975319, PubMed:15824063). Increases U7 snRNA levels but not histone 3'-end pre-mRNA processing activity, when overexpressed (PubMed:12975319, PubMed:15824063). Required for cell cycle progression from G1 to S phases (PubMed:16914750). Binds specifically to the Sm-binding site of U7 snRNA. {ECO:0000269|PubMed:12975319, ECO:0000269|PubMed:15824063, ECO:0000269|PubMed:16914750}.
uniprot
proteins
mass_dalton
39907
uniprot
proteins
mutagenesis
MUTAGEN 33..35; /note="PLL->AAA: Does not inhibit interaction with ZNF473. Strongly reduces histone 3' end processing."; /evidence="ECO:0000269|PubMed:15824063"; MUTAGEN 59..61; /note="YES->AAA: Does not inhibit interaction with ZNF473 and histone 3'-end processing."; /evidence="ECO:0000269|PubMed:15824063"; MUTAGEN 108..110; /note="PER->AAA: Does not inhibit interaction with ZNF473. Reduces weakly histone 3' end processing."; /evidence="ECO:0000269|PubMed:15824063"; MUTAGEN 149..151; /note="MPL->AAA: Does not inhibit interaction with ZNF473. Reduces weakly histone 3' end processing."; /evidence="ECO:0000269|PubMed:15824063
uniprot
proteins
post_translational_modification
PTM: Not methylated. {ECO:0000269|PubMed:16087681}.
uniprot
proteins
protein_family
SnRNP Sm proteins family
uniprot
proteins
pubmed
12975319
uniprot
proteins
pubmed
15824063
uniprot
proteins
pubmed
16087681
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16914750
uniprot
proteins
pubmed
19470752
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
361
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P83369}.
uniprot
proteins