ACSL3
entrez
2181
canonical
uniprot
O95573
canonical
ensembl
ENSG00000123983
resolver
ensp
ENSP00000350012
resolver
ensp
ENSP00000375918
resolver
ensp
ENSP00000504861
resolver
ensp
ENSP00000504907
resolver
ensp
ENSP00000505400
resolver
ensp
ENSP00000505654
resolver
ensp
ENSP00000505793
resolver
ensp
ENSP00000505856
resolver
ensp
ENSP00000505940
resolver
ensp
ENSP00000506361
resolver
ensp
ENSP00000506468
resolver
ensp
ENSP00000573440
resolver
ensp
ENSP00000573441
resolver
ensp
ENSP00000573442
resolver
ensp
ENSP00000573443
resolver
ensp
ENSP00000625435
resolver
ensp
ENSP00000625436
resolver
ensp
ENSP00000625437
resolver
ensp
ENSP00000625438
resolver
ensp
ENSP00000625441
resolver
enst
ENST00000357430
resolver
enst
ENST00000392066
resolver
enst
ENST00000679514
resolver
enst
ENST00000679558
resolver
enst
ENST00000680147
resolver
enst
ENST00000680251
resolver
enst
ENST00000680395
resolver
enst
ENST00000680684
resolver
enst
ENST00000680921
resolver
enst
ENST00000681383
resolver
enst
ENST00000681697
resolver
enst
ENST00000903381
resolver
enst
ENST00000903382
resolver
enst
ENST00000903383
resolver
enst
ENST00000903384
resolver
enst
ENST00000955376
resolver
enst
ENST00000955377
resolver
enst
ENST00000955378
resolver
enst
ENST00000955379
resolver
enst
ENST00000955382
resolver
genesymbol
ACSL3
resolver
genesymbol_syn
ACS3
resolver
genesymbol_syn
FACL3
resolver
genesymbol_syn
LACS3
resolver
hgnc
HGNC:3570
resolver
uniprot
Q60I92
resolver
uniprot
Q8IUM9
resolver
uniprot_entry
ACSL3_HUMAN
resolver
uniprot_sec
Q60I92
resolver
uniprot_sec
Q8IUM9
resolver
amino_acid_sequence
MNNHVSSKPSTMKLKHTINPILLYFIHFLISLYTILTYIPFYFFSESRQEKSNRIKAKPVNSKPDSAYRSVNSLDGLASVLYPGCDTLDKVFTYAKNKFKNKRLLGTREVLNEEDEVQPNGKIFKKVILGQYNWLSYEDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAAQACFMYNFQLVTLYATLGGPAIVHALNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDGKPPTWSEFPKGIIVHTMAAVEALGAKASMENQPHSKPLPSDIAVIMYTSGSTGLPKGVMISHSNIIAGITGMAERIPELGEEDVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQSSKIKKGSKGDTSMLKPTLMAAVPEIMDRIYKNVMNKVSEMSSFQRNLFILAYNYKMEQISKGRNTPLCDSFVFRKVRSLLGGNIRLLLCGGAPLSATTQRFMNICFCCPVGQGYGLTESAGAGTISEVWDYNTGRVGAPLVCCEIKLKNWEEGGYFNTDKPHPRGEILIGGQSVTMGYYKNEAKTKADFFEDENGQRWLCTGDIGEFEPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAALKNLPLVDNICAYANSYHSYVIGFVVPNQKELTELARKKGLKGTWEELCNSCEMENEVLKVLSEAAISASLEKFEIPVKIRLSPEPWTPETGLVTDAFKLKRKELKTHYQADIERMYGRK
uniprot
proteins
ec_number
6.2.1.15
uniprot
proteins
ec_number
6.2.1.2
uniprot
proteins
ec_number
6.2.1.3
uniprot
proteins
function
FUNCTION: Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation (PubMed:22633490). Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL (very low density lipoproteins) (PubMed:18003621). Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity (By similarity). {ECO:0000250|UniProtKB:Q63151, ECO:0000269|PubMed:18003621, ECO:0000269|PubMed:22633490}.
uniprot
proteins
mass_dalton
80420
uniprot
proteins
protein_family
ATP-dependent AMP-binding enzyme family
uniprot
proteins
pubmed
11707336
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18003621
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22633490
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
9177793
uniprot
proteins
sequence_length
720
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..41; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins