COIL
entrez
8161
canonical
uniprot
P38432
canonical
ensembl
ENSG00000121058
resolver
ensp
ENSP00000240316
resolver
enst
ENST00000240316
resolver
genesymbol
COIL
resolver
genesymbol_syn
CLN80
resolver
hgnc
HGNC:2184
resolver
uniprot
B2R931
resolver
uniprot_entry
COIL_HUMAN
resolver
uniprot_sec
B2R931
resolver
amino_acid_sequence
MAASETVRLRLQFDYPPPATPHCTAFWLLVDLNRCRVVTDLISLIRQRFGFSSGAFLGLYLEGGLLPPAESARLVRDNDCLRVKLEERGVAENSVVISNGDINLSLRKAKKRAFQLEEGEETEPDCKYSKKHWKSRENNNNNEKVLDLEPKAVTDQTVSKKNKRKNKATCGTVGDDNEEAKRKSPKKKEKCEYKKKAKNPKSPKVQAVKDWANQRCSSPKGSARNSLVKAKRKGSVSVCSKESPSSSSESESCDESISDGPSKVTLEARNSSEKLPTELSKEEPSTKNTTADKLAIKLGFSLTPSKGKTSGTTSSSSDSSAESDDQCLMSSSTPECAAGFLKTVGLFAGRGRPGPGLSSQTAGAAGWRRSGSNGGGQAPGASPSVSLPASLGRGWGREENLFSWKGAKGRGMRGRGRGRGHPVSCVVNRSTDNQRQQQLNDVVKNSSTIIQNPVETPKKDYSLLPLLAAAPQVGEKIAFKLLELTSSYSPDVSDYKEGRILSHNPETQQVDIEILSSLPALREPGKFDLVYHNENGAEVVEYAVTQESKITVFWKELIDPRLIIESPSNTSSTEPA
uniprot
proteins
function
FUNCTION: Component of nuclear coiled bodies, also known as Cajal bodies or CBs, which are involved in the modification and assembly of nucleoplasmic snRNPs. {ECO:0000269|PubMed:7679389}.
uniprot
proteins
mass_dalton
62608
uniprot
proteins
mutagenesis
MUTAGEN 413..419; /note="RGRGRGR->GGGGGGG: Impaired interaction with SMN."; /evidence="ECO:0000269|PubMed:11641277
uniprot
proteins
post_translational_modification
PTM: Symmetrical dimethylation of arginine residues within the RG repeat region enhances affinity for SMN, and thus localization of SMN complexes to CBs.; PTM: Phosphorylated by VRK1 (PubMed:31527692). Phosphorylation during mitosis is associated with disassembly of CBs. {ECO:0000269|PubMed:21920476, ECO:0000269|PubMed:31527692, ECO:0000269|PubMed:7679389}.
uniprot
proteins
protein_family
Coilin family
uniprot
proteins
pubmed
11641277
uniprot
proteins
pubmed
12361597
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15862129
uniprot
proteins
pubmed
16079131
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
2033369
uniprot
proteins
pubmed
20875822
uniprot
proteins
pubmed
21072240
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21920476
uniprot
proteins
pubmed
22547674
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23685356
uniprot
proteins
pubmed
23726919
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
29934401
uniprot
proteins
pubmed
31527692
uniprot
proteins
pubmed
7679389
uniprot
proteins
pubmed
7971277
uniprot
proteins
sequence_length
576
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:7679389}. Nucleus, Cajal body {ECO:0000269|PubMed:16079131, ECO:0000269|PubMed:22547674, ECO:0000269|PubMed:23726919, ECO:0000269|PubMed:7679389}.
uniprot
proteins