SLURP2
entrez
432355
canonical
uniprot
P0DP57
canonical
ensembl
ENSG00000283992
resolver
ensp
ENSP00000319846
resolver
ensp
ENSP00000428465
resolver
enst
ENST00000317543
resolver
genesymbol
SLURP2
resolver
hgnc
HGNC:25549
resolver
uniprot
D3DWI7
resolver
uniprot
G3XAC2
resolver
uniprot
Q86SR0
resolver
uniprot
Q9BZG9
resolver
uniprot_entry
SLUR2_HUMAN
resolver
uniprot_sec
D3DWI7
resolver
uniprot_sec
G3XAC2
resolver
uniprot_sec
Q86SR0
resolver
uniprot_sec
Q9BZG9
resolver
amino_acid_sequence
MQLGTGLLLAAVLSLQLAAAEAIWCHQCTGFGGCSHGSRCLRDSTHCVTTATRVLSNTEDLPLVTKMCHIGCPDIPSLGLGPYVSIACCQTSLCNHD
uniprot
proteins
function
FUNCTION: Binds and may modulate the functional properties of nicotinic and muscarinic acetylcholine receptors. May regulate keratinocytes proliferation, differentiation and apoptosis. In vitro moderately inhibits ACh-evoked currents of alpha-3:beta-2-containing nAChRs and strongly these of alpha-4:beta-2-containing nAChRs, modulates alpha-7-containing nAChRs, and inhibits nicotine-induced signaling probably implicating alpha-3:beta-4-containing nAChRs. Proposed to act on alpha-3:beta-2 and alpha-7 nAChRs in an orthosteric, and on mAChRs, such as CHRM1 and CHRM3, in an allosteric manner. {ECO:0000269|PubMed:16575903, ECO:0000269|PubMed:27485575}.
uniprot
proteins
mass_dalton
10160
uniprot
proteins
pubmed
12573258
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
16575903
uniprot
proteins
pubmed
26033490
uniprot
proteins
pubmed
27485575
uniprot
proteins
sequence_length
97
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16575903}.
uniprot
proteins