Isyna1
entrez
290651
canonical
uniprot
Q6AYK3
canonical
ensembl
ENSRNOG00000019741
resolver
ensembl
ENSRNOG00055010351
resolver
ensembl
ENSRNOG00060009375
resolver
ensembl
ENSRNOG00065022942
resolver
ensp
ENSRNOP00000026821
resolver
genesymbol
Isyna1
resolver
genesymbol_syn
Ino1
resolver
uniprot_entry
INO1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by 2-deoxyglucitol 6-phosphate (dgtolP) and 2-deoxy-D-glucose 6-phosphate (PubMed:6773943). Inhibited by copper, mercury, cadmium, zinc and copper ions (PubMed:6773943). Activated by potassium and ammonium ions (PubMed:6773943). {ECO:0000269|PubMed:6773943}.
uniprot
proteins
amino_acid_sequence
MEPAAEILVDSPDVIFGPEAIEARYEYRTTRVSREGGVLRVRPTATRFTFRTARQVPRLGVMLVGWGGNNGSTLTAAVLANRLRLTWPTRTGRKEANYYGSLTQAGTVNLGLDGDGREVFVPFSALLPMVAPNDLVFDGWDISSLNLAEAMRRAQVLDCGLQEQLWPHMESLRPRPSVYIPEFIAANQTARADNLIPGTRAQQLEQIRKDIRDFRSSAGLDKVIVLWTANTERFCEVVPGRNDTAENLLRTIQLGLEVSPSTLFAVASILEGCAFLNGSPQNTLVPGALELASQRHVFVGGDDFKSGQTKVKSVLVDFLIGSGLKTMSIVSYNHLGNNDGQNLSAPLQFRSKEVTKSSVVDDMVQSNRVLYAPGEEPDHCVVIKYVPYVGDSKRALDEYTSELMLGGTNTLVLHNTCEDSLLAAPIMLDLVLLTELCQRVSFCTDSDPEPQGFHPVLSVLSFLFKAPLVPPGSPVVNALFRQRSCIENIFRACVGLPPQNHMLLEHKMERPFPGIKPEEVKATSPLPCKKESTPATNGCTGDANGHTQAPTPELSTA
uniprot
proteins
ec_number
5.5.1.4
uniprot
proteins
function
FUNCTION: Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner (PubMed:23504145, PubMed:6773943, PubMed:885873). Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity). {ECO:0000250|UniProtKB:Q9NPH2, ECO:0000269|PubMed:23504145, ECO:0000269|PubMed:6773943, ECO:0000269|PubMed:885873}.; FUNCTION: [Isoform 1]: Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. {ECO:0000269|PubMed:19188364}.; FUNCTION: [Isoform 2]: Competitively inhibits the function of isoform 1, presumably by competing for NAD cofactor. {ECO:0000269|PubMed:19188364}.
uniprot
proteins
mass_dalton
60884
uniprot
proteins
pathway_participation
PATHWAY: Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-524 does not appear to affect enzyme activity, and is detected in brain and testis. {ECO:0000269|PubMed:23504145}.
uniprot
proteins
protein_family
Myo-inositol 1-phosphate synthase family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
19188364
uniprot
proteins
pubmed
23504145
uniprot
proteins
pubmed
6773943
uniprot
proteins
pubmed
885873
uniprot
proteins
sequence_length
557
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P11986}.
uniprot
proteins