P0DJI6
uniprot
P0DJI6
canonical
amino_acid_sequence
MGGPTRRHQEEGSAECLGGPSTRAAPGPGLRDFHFTTAGPSKADRLGDAAQIHRERMRPVQCGDGSGERVFLQSPGSIGTLYIRLDLNSQRSTCCCLLNAGTKGMC
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
function
FUNCTION: Regulator of adipocytes that acts by repressing FOXO1 transcriptional activity. Acts by promoting acetylation of FOXO1, both by preventing the interaction between FOXO1 and SIRT1 deacetylase, and by mediating acetyltransferase activity in vitro. Regulates insulin sensitivity and energy metabolism. {ECO:0000269|PubMed:22510882}.
uniprot
proteins
mass_dalton
11233
uniprot
proteins
mutagenesis
MUTAGEN 78; /note="I->A: Abolishes inhibition of FOXO1 transcriptional activity."; /evidence="ECO:0000269|PubMed:22510882"; MUTAGEN 80; /note="T->A: Abolishes inhibition of FOXO1 transcriptional activity."; /evidence="ECO:0000269|PubMed:22510882"; MUTAGEN 81; /note="L->A: Enhances FOXO1 nuclear translocation but does not abolish inhibition of FOXO1 transcriptional activity in the absence of forskolin."; /evidence="ECO:0000269|PubMed:22510882"; MUTAGEN 85; /note="L->A: Abolishes inhibition of FOXO1 transcriptional activity."; /evidence="ECO:0000269|PubMed:22510882"; MUTAGEN 87; /note="L->A: Abolishes inhibition of FOXO1 transcriptional activity."; /evidence="ECO:0000269|PubMed:22510882"; MUTAGEN 92; /note="S->A: Does not inhibit subcellular localization. Does not affect phosphorylation in response to forskolin."; /evidence="ECO:0000269|PubMed:22510882"; MUTAGEN 93; /note="T->A: Abolishes phosphorylation in response to forskolin. Localizes mainly to the cytosol. Weakly enhances FOXO1 acetylation. Weakly abolishes inhibition of FOXO1 transcriptional activity."; /evidence="ECO:0000269|PubMed:22510882"; MUTAGEN 93; /note="T->D: Mimicks phosphorylation state, localizes mainly to the nucleus. Strongly enhances FOXO1 acetylation. Strongly abolishes inhibition of FOXO1 transcriptional activity."; /evidence="ECO:0000269|PubMed:22510882
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Thr-93 by PKA, leading to import into the nucleus. {ECO:0000269|PubMed:22510882}.
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22510882
uniprot
proteins
sequence_length
106
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:22510882}. Nucleus {ECO:0000269|PubMed:22510882}. Note=Imported into the nucleus following phosphorylation at Thr-93 upon treatment of cells with forskolin. Probably shuttles between the nucleus and the cytoplasm.
uniprot
proteins