Ogdh
entrez
18293
canonical
uniprot
Q60597
canonical
ensembl
ENSMUSG00000020456
resolver
ensp
ENSMUSP00000003461
resolver
ensp
ENSMUSP00000080569
resolver
ensp
ENSMUSP00000091041
resolver
ensp
ENSMUSP00000099090
resolver
ensp
ENSMUSP00000166306
resolver
ensp
ENSMUSP00000166309
resolver
ensp
ENSMUSP00000166312
resolver
ensp
ENSMUSP00000166313
resolver
ensp
ENSMUSP00000166396
resolver
ensp
ENSMUSP00000327281
resolver
ensp
ENSMUSP00000353884
resolver
enst
ENSMUST00000081894
resolver
genesymbol
Ogdh
resolver
genesymbol_syn
Kiaa4192
resolver
uniprot
Q3UDM7
resolver
uniprot
Q5DTI4
resolver
uniprot
Q5SVX7
resolver
uniprot
Q5SVX9
resolver
uniprot
Q6PFZ2
resolver
uniprot
Q80Y57
resolver
uniprot
Q8K0K7
resolver
uniprot
Q8K2Z3
resolver
uniprot
Q8R3M2
resolver
uniprot
Q91WP2
resolver
uniprot
Z4YJV4
resolver
uniprot_entry
ODO1_MOUSE
resolver
uniprot_entry
Z4YJV4_MOUSE
resolver
uniprot_sec
Q3UDM7
resolver
uniprot_sec
Q5DTI4
resolver
uniprot_sec
Q5SVX7
resolver
uniprot_sec
Q5SVX9
resolver
uniprot_sec
Q6PFZ2
resolver
uniprot_sec
Q80Y57
resolver
uniprot_sec
Q8K0K7
resolver
uniprot_sec
Q8K2Z3
resolver
uniprot_sec
Q8R3M2
resolver
uniprot_sec
Q91WP2
resolver
activity_regulation
ACTIVITY REGULATION: Calcium ions and ADP stimulate, whereas ATP and NADH reduce catalytic activity. {ECO:0000250|UniProtKB:Q02218}.
uniprot
proteins
amino_acid_sequence
MFHLRTCAAKLRPLTASQTVKTFSQNKPAAIRTFQQIRCYSAPVAAEPFLSGTSSNYVEEMYCAWLENPKSVHKSWDIFFRNTNAGAPPGTAYQSPLSLSRSSLATMAHAQSLVEAQPNVDKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSSVPADIISSTDKLGFYGLHESDLDKVFHLPTTTFIGGQEPALPLREIIRRLEMAYCQHIGVEFMFINDLEQCQWIRQKFETPGIMQFTNEEKRTLLARLVRSTRFEEFLQRKWSSEKRFGLEGCEVLIPALKTIIDMSSANGVDYVIMGMPHRGRLNVLANVIRKELEQIFCQFDSKLEAADEGSGDMKYHLGMYHRRINRVTDRNITLSLVANPSHLEAADPVVMGKTKAEQFYCGDTEGKKVMSILLHGDAAFAGQGIVYETFHLSDLPSYTTHGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNSDDPEAVMYVCKVAAEWRNTFHKDVVVDLVCYRRNGHNEMDEPMFTQPLMYKQIRKQKPVLQKYAELLVSQGVVNQPEYEEEISKYDKICEEAFTRSKDEKILHIKHWLDSPWPGFFTLDGQPRSMTCPSTGLEEDVLFHIGKVASSVPVENFTIHGGLSRILKTRRELVTNRTVDWALAEYMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHDQNVDKRTCIPMNHLWPNQAPYTVCNSSLSEYGVLGFELGFAMASPNALVLWEAQFGDFNNMAQCIIDQFICPGQAKWVRQNGIVLLLPHGMEGMGPEHSSARPERFLQMCNDDPDVLPDLQEENFDINQLYDCNWIVVNCSTPGNFFHVLRRQILLPFRKPLIVFTPKSLLRHPEARTSFDEMLPGTHFQRVIPENGPAAQDPHKVKRLLFCTGKVYYDLTRERKARNMEEEVAITRIEQLSPFPFDLLLKEAQKYPNAELAWCQEEHKNQGYYDYVKPRLRTTIDRAKPVWYAGRDPAAAPATGNKKTHLTELQRFLDTAFDLDAFKKFS
uniprot
proteins
ec_number
1.2.4.2
uniprot
proteins
function
FUNCTION: 2-oxoglutarate dehydrogenase (E1o) component of the 2-oxoglutarate dehydrogenase complex (OGDHC). Participates in the first step, rate limiting for the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) catalyzed by the whole OGDHC. Catalyzes the irreversible decarboxylation of 2-oxoglutarate (alpha-ketoglutarate) via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST). Plays a key role in the Krebs (citric acid) cycle, which is a common pathway for oxidation of fuel molecules, including carbohydrates, fatty acids, and amino acids. Can catalyze the decarboxylation of 2-oxoadipate in vitro, but at a much lower rate than 2-oxoglutarate. Can also convert 2-keto-4-hydroxyglutarate (KHG) and CoA into malyl-CoA. Mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. {ECO:0000250|UniProtKB:K9IVI1, ECO:0000250|UniProtKB:Q02218}.
uniprot
proteins
mass_dalton
116449
uniprot
proteins
protein_family
Alpha-ketoglutarate dehydrogenase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1606619
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
36854377
uniprot
proteins
pubmed
8248240
uniprot
proteins
sequence_length
1023
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q5XI78}. Nucleus {ECO:0000250|UniProtKB:Q02218}. Note=Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2-oxoglutarate dehydrogenase complex is required for histone succinylation. {ECO:0000250|UniProtKB:Q02218}.
uniprot
proteins