MAPK4
entrez
5596
canonical
uniprot
P31152
canonical
ensembl
ENSG00000141639
resolver
ensp
ENSP00000383234
resolver
ensp
ENSP00000439231
resolver
ensp
ENSP00000466233
resolver
ensp
ENSP00000573394
resolver
ensp
ENSP00000573397
resolver
ensp
ENSP00000573399
resolver
ensp
ENSP00000573401
resolver
ensp
ENSP00000573404
resolver
ensp
ENSP00000573406
resolver
ensp
ENSP00000612425
resolver
ensp
ENSP00000612426
resolver
enst
ENST00000400384
resolver
enst
ENST00000540640
resolver
enst
ENST00000592595
resolver
enst
ENST00000903334
resolver
enst
ENST00000903337
resolver
enst
ENST00000903340
resolver
enst
ENST00000903342
resolver
enst
ENST00000903345
resolver
enst
ENST00000903347
resolver
enst
ENST00000942366
resolver
enst
ENST00000942367
resolver
genesymbol
MAPK4
resolver
genesymbol_syn
ERK4
resolver
genesymbol_syn
PRKM4
resolver
hgnc
HGNC:6878
resolver
uniprot
A1A4C4
resolver
uniprot
B4DEW2
resolver
uniprot
F6RKE6
resolver
uniprot
K7ELV1
resolver
uniprot
Q0VG04
resolver
uniprot_entry
B4DEW2_HUMAN
resolver
uniprot_entry
F6RKE6_HUMAN
resolver
uniprot_entry
K7ELV1_HUMAN
resolver
uniprot_entry
MK04_HUMAN
resolver
uniprot_sec
A1A4C4
resolver
uniprot_sec
Q0VG04
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation at Ser-186.
uniprot
proteins
amino_acid_sequence
MAEKGDCIASVYGYDLGGRFVDFQPLGFGVNGLVLSAVDSRACRKVAVKKIALSDARSMKHALREIKIIRRLDHDNIVKVYEVLGPKGTDLQGELFKFSVAYIVQEYMETDLARLLEQGTLAEEHAKLFMYQLLRGLKYIHSANVLHRDLKPANIFISTEDLVLKIGDFGLARIVDQHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCILAEMLTGRMLFAGAHELEQMQLILETIPVIREEDKDELLRVMPSFVSSTWEVKRPLRKLLPEVNSEAIDFLEKILTFNPMDRLTAEMGLQHPYMSPYSCPEDEPTSQHPFRIEDEIDDIVLMAANQSQLSNWDTCSSRYPVSLSSDLEWRPDRCQDASEVQRDPRAGSAPLAEDVQVDPRKDSHSSSERFLEQSHSSMERAFEADYGRSCDYKVGSPSYLDKLLWRDNKPHHYSEPKLILDLSHWKQAAGAPPTATGLADTGAREDEPASLFLEIAQWVKSTQGGPEHASPPADDPERRLSASPPGRPAPVDGGASPQFDLDVFISRALKLCTKPEDLPDNKLGDLNGACIPEHPGDLVQTEAFSKERW
uniprot
proteins
ec_number
2.7.11.24
uniprot
proteins
function
FUNCTION: Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
65922
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-186 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites. {ECO:0000269|PubMed:21177870}.
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
MAP kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
1319925
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21177870
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
587
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocates to the cytoplasm following interaction with MAPKAPK5. {ECO:0000250}.
uniprot
proteins