RtcA
entrez
66368
canonical
uniprot
Q9D7H3
canonical
ensembl
ENSMUSG00000000339
resolver
ensp
ENSMUSP00000000348
resolver
enst
ENSMUST00000000348
resolver
genesymbol
RtcA
resolver
genesymbol_syn
Rpc1
resolver
genesymbol_syn
Rtcd1
resolver
uniprot
Q3TVV2
resolver
uniprot_entry
RTCA_MOUSE
resolver
uniprot_sec
Q3TVV2
resolver
amino_acid_sequence
MEGQRVEVDGGIMEGGGQILRVSTALSCLLGLPLRVQKIRAGRSTPGLRPQHLSGLEMVRDLCGGHLEGAEIGSTEITFTPEKIRGGVHTADTKTAGSVCLLMQVSMPCVLFAASPSELRLKGGTNAEMAPQIDYTMMVFKPIAEKFGFTFNCDIKTRGYYPKGGGEVIVRVSPVKRLDPINLTDRGSVTKIYGRAFVAGVLPLKVAKDMAAAAVRCIRKEIRDLYVSIQPVQEARDQAFGNGSGIIIVAETSTGCLFAGSSLGKRGVNADKVGIEAAEMLLANLRHGGTVDEYLQDQLIIFMALANGISRIKTGSVTLHTQTAIHFAEQLAKAKFTVKKSEEEEDATKDTYVIECEGIGMANPHL
uniprot
proteins
ec_number
6.5.1.4
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA (By similarity). The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product (By similarity). Likely functions in some aspects of cellular RNA processing (PubMed:25961792). Function plays an important role in regulating axon regeneration by inhibiting central nervous system (CNS) axon regeneration following optic nerve injury (PubMed:25961792). {ECO:0000250|UniProtKB:O00442, ECO:0000269|PubMed:25961792}.
uniprot
proteins
mass_dalton
39254
uniprot
proteins
protein_family
RNA 3'-terminal cyclase family
uniprot
proteins
protein_family
Type 1 subfamily
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25961792
uniprot
proteins
sequence_length
366
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:O00442}.
uniprot
proteins