P0C1T0
uniprot
P0C1T0
canonical
activity_regulation
ACTIVITY REGULATION: Inhibited by thiorphan and phosphoramidon.
uniprot
proteins
amino_acid_sequence
MGKSESSVGMMERADNCGRRRLGFVECGLLVLLTLLLMGAIVTLGVFYSIGKQLPLLNSLLHVSRHERTVVKRVLRDSSQKSDICTTPSCVIAAARILQNMDQSKKPCDNFYQYACGGWLRHHVIPETNSRYSVFDILRDELEVILKGVLEDSSVQHRPAVEKAKTLYRSCMNQSVIEKRDSEPLLNVLDMIGGWPVAMDKWNETMGPKWELERQLAVLNSQFNRRVLIDLFIWNDDQNSSRHVIYIDQPTLGMPSREYYFKEDSHRVREAYLQFMTSVATMLRRDLNLPGETDLVQEEMAQVLHLETHLANATVPQEKRHDVTALYHRMGLEELQERFGLKGFNWTLFIQNVLSSVQVELLPNEEVVVYGIPYLENLEEIIDVFPAQTLQNYLVWRLVLDRIGSLSQRFKEARVDYRKALYGTTMEEVRWRECVSYVNSNMESAVGSLYIKRAFSKDSKSIVSELIEKIRSVFVDNLDELNWMDEESKKKAQEKALNIREQIGYPDYILEDNNRHLDEEYSSLTFSEDLYFENGLQNLKNNAQRSLKKLREKVDQNLWIIGAAVVNAFYSPNRNLIVFPAGILQPPFFSKDQPQALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMLDWWSNFSARHFRQQSQCMIYQYSNFSWELADNQNVNGFSTLGENIADNGGVRQAYKAYLQWLAEGGRDQRLPGLNLTYAQLFFINYAQVWCGSYRPEFAIQSIKTDVHSPLNAQVLGSLQNLPGFSEAFHCPRGSPMHPMNRCRIW
uniprot
proteins
ec_number
3.4.24.11
uniprot
proteins
function
FUNCTION: Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
89197
uniprot
proteins
mutagenesis
MUTAGEN 131; /note="R->M: Impairs binding of free carboxylate group of substrates."; /evidence="ECO:0000269|PubMed:15294904"; MUTAGEN 133; /note="S->G: Impairs both substrate-binding and enzyme activity."; /evidence="ECO:0000269|PubMed:15294904"; MUTAGEN 567; /note="N->G: Impairs the enzyme specificity."; /evidence="ECO:0000269|PubMed:15294904"; MUTAGEN 739; /note="L->G: Impairs both substrate-binding and enzyme activity."; /evidence="ECO:0000269|PubMed:15294904"; MUTAGEN 751; /note="P->A: Loss of function."; /evidence="ECO:0000269|PubMed:16081046"; MUTAGEN 764; /note="P->Y: Induces a 3-fold decrease of specific activity."; /evidence="ECO:0000269|PubMed:16081046"; MUTAGEN 774; /note="W->F: No effect."; /evidence="ECO:0000269|PubMed:16081046
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:11964170}.
uniprot
proteins
protein_family
Peptidase M13 family
uniprot
proteins
pubmed
10814502
uniprot
proteins
pubmed
11964170
uniprot
proteins
pubmed
12710972
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15294904
uniprot
proteins
pubmed
16081046
uniprot
proteins
sequence_length
774
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein. Secreted. Note=A secreted form produced by proteolytic cleavage also exists. {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 27..47; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins