TSGA10
entrez
80705
canonical
uniprot
Q9BZW7
canonical
ensembl
ENSG00000135951
resolver
ensp
ENSP00000347161
resolver
ensp
ENSP00000377122
resolver
ensp
ENSP00000377123
resolver
ensp
ENSP00000386956
resolver
ensp
ENSP00000501312
resolver
ensp
ENSP00000521827
resolver
ensp
ENSP00000521828
resolver
ensp
ENSP00000521833
resolver
ensp
ENSP00000521837
resolver
ensp
ENSP00000521839
resolver
ensp
ENSP00000641033
resolver
ensp
ENSP00000641036
resolver
genesymbol
TSGA10
resolver
genesymbol_syn
CEP4L
resolver
hgnc
HGNC:14927
resolver
uniprot
A0A218MIY9
resolver
uniprot
B7Z925
resolver
uniprot
D3DVH7
resolver
uniprot
Q8NEP0
resolver
uniprot
Q9BWX0
resolver
uniprot_entry
A0A218MIY9_HUMAN
resolver
uniprot_entry
TSG10_HUMAN
resolver
uniprot_sec
B7Z925
resolver
uniprot_sec
D3DVH7
resolver
uniprot_sec
Q8NEP0
resolver
uniprot_sec
Q9BWX0
resolver
amino_acid_sequence
MMRSRSKSPRRPSPTARGANCDVELLKTTTRDREELKCMLEKYERHLAEIQGNVKVLKSERDKIFLLYEQAQEEITRLRREMMKSCKSPKSTTAHAILRRVETERDVAFTDLRRMTTERDSLRERLKIAQETAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETISTVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILGGTLNDLAKEKECLQACLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQCTEALIVCEQDVSRMRRQLDETNDELAQIARERDILAHDNDNLQEQFAKAKQENQALSKKLNDTHNELNDIKQKVQDTNLEVNKLKNILKSEESENRQMMEQLRKANEDAENWENKARQSEADNNTLKLELITAEAEGNRLKEKVDSLNREVEQHLNAERSYKSQISTLHKSVVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMRENELDSAHSEIELLRSQMANERISMQNLEALLVANRDKEYQSQIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELRRQNYSSNAYHMSSTMKPNTKCHSPERAHHRSPDRGLDRSLEENLCYRDF
uniprot
proteins
disease_involvement
DISEASE: Spermatogenic failure 26 (SPGF26) [MIM:617961]: An autosomal recessive infertility disorder caused by spermatogenesis defects that result in acephalic spermatozoa. {ECO:0000269|PubMed:28905369}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Plays a role in spermatogenesis (PubMed:28905369). When overexpressed, prevents nuclear localization of HIF1A (By similarity). {ECO:0000250|UniProtKB:Q6NY15, ECO:0000269|PubMed:28905369}.
uniprot
proteins
mass_dalton
81421
uniprot
proteins
post_translational_modification
PTM: Processed into N-terminal 27-kDa and C-terminal 55-kDa fragments. {ECO:0000250|UniProtKB:Q6NY15}.
uniprot
proteins
protein_family
CEP135/TSGA10 family
uniprot
proteins
pubmed
11179690
uniprot
proteins
pubmed
14585816
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
28905369
uniprot
proteins
sequence_length
698
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Z220}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:28905369}. Note=In mature spermatozoa, localizes to the centriole and midpiece (PubMed:28905369). The 27-kDa peptide associates with the fibrous sheath in mature spermatozoa and localizes to the principal piece of sperm tail, while the 55-kDa peptide localizes to the midpiece (By similarity). Detected in the cytoplasm of almost all spermatogonial cells within the seminiferous tubules (By similarity). {ECO:0000250|UniProtKB:Q9Z220, ECO:0000269|PubMed:28905369}.
uniprot
proteins