Prrx1
entrez
18933
canonical
uniprot
P63013
canonical
ensembl
ENSMUSG00000026586
resolver
ensp
ENSMUSP00000027878
resolver
ensp
ENSMUSP00000075203
resolver
ensp
ENSMUSP00000134338
resolver
ensp
ENSMUSP00000246738
resolver
enst
ENSMUST00000174397
resolver
genesymbol
Prrx1
resolver
genesymbol_syn
Pmx
resolver
genesymbol_syn
Pmx1
resolver
uniprot
G3UZ44
resolver
uniprot
P43271
resolver
uniprot
Q02810
resolver
uniprot
Q569N6
resolver
uniprot_entry
G3UZ44_MOUSE
resolver
uniprot_entry
PRRX1_MOUSE
resolver
uniprot_sec
P43271
resolver
uniprot_sec
Q02810
resolver
uniprot_sec
Q569N6
resolver
amino_acid_sequence
MTSSYGHVLERQPALGGRLDSPGNLDTLQAKKNFSVSHLLDLEEAGDMVAAQADESVGEAGRSLLESPGLTSGSDTPQQDNDQLNSEEKKKRKQRRNRTTFNSSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQVWFQNRRAKFRRNERAMLANKNASLLKSYSGDVTAVEQPIVPRPAPRPTDYLSWGTASPYSAMATYSATCANNSPAQGINMANSIANLRLKAKEYSLQRNQVPTVN
uniprot
proteins
function
FUNCTION: Master transcription factor of stromal fibroblasts for myofibroblastic lineage progression. Orchestrates the functional drift of fibroblasts into myofibroblastic phenotype via TGF-beta signaling by remodeling a super-enhancer landscape. Through this function, plays an essential role in wound healing process (PubMed:35589735). Acts as a transcriptional regulator of muscle creatine kinase (MCK) and so has a role in the establishment of diverse mesodermal muscle types. The protein binds to an A/T-rich element in the muscle creatine enhancer (PubMed:1360403). May play a role in homeostasis and regeneration of bone, white adipose tissue and derm (PubMed:36456880). {ECO:0000269|PubMed:1360403, ECO:0000269|PubMed:35589735, ECO:0000269|PubMed:36456880}.; FUNCTION: [Isoform 1]: Transcriptional activator, when transfected in fibroblastic or myoblastic cell lines. This activity may be masked by the C-terminal OAR domain. {ECO:0000269|PubMed:11373278}.; FUNCTION: [Isoform 2]: Transcriptional repressor, when transfected in fibroblastic or myoblastic cell lines. {ECO:0000269|PubMed:11373278}.
uniprot
proteins
mass_dalton
27269
uniprot
proteins
mutagenesis
MUTAGEN 223; /note="S->P: No effect on transcriptional activity."; /evidence="ECO:0000269|PubMed:11373278"; MUTAGEN 226; /note="N->P: No effect on transcriptional activity."; /evidence="ECO:0000269|PubMed:11373278"; MUTAGEN 228; /note="R->A,P: Increased transcriptional activation. No effect on DNA binding."; /evidence="ECO:0000269|PubMed:11373278
uniprot
proteins
protein_family
Paired homeobox family
uniprot
proteins
pubmed
11373278
uniprot
proteins
pubmed
1360403
uniprot
proteins
pubmed
1383943
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
35589735
uniprot
proteins
pubmed
36456880
uniprot
proteins
pubmed
7910581
uniprot
proteins
sequence_length
245
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:35589735}.
uniprot
proteins