RCCD1
entrez
91433
canonical
uniprot
A6NED2
canonical
ensembl
ENSG00000166965
resolver
ensp
ENSP00000377801
resolver
ensp
ENSP00000451963
resolver
ensp
ENSP00000523040
resolver
ensp
ENSP00000523041
resolver
ensp
ENSP00000523042
resolver
ensp
ENSP00000523046
resolver
ensp
ENSP00000605414
resolver
ensp
ENSP00000605417
resolver
ensp
ENSP00000684529
resolver
enst
ENST00000394258
resolver
enst
ENST00000556618
resolver
enst
ENST00000852981
resolver
enst
ENST00000852982
resolver
enst
ENST00000852983
resolver
enst
ENST00000852987
resolver
enst
ENST00000935355
resolver
enst
ENST00000935358
resolver
genesymbol
RCCD1
resolver
hgnc
HGNC:30457
resolver
uniprot
B2RTP9
resolver
uniprot
Q29RX6
resolver
uniprot_entry
RCCD1_HUMAN
resolver
uniprot_sec
B2RTP9
resolver
uniprot_sec
Q29RX6
resolver
amino_acid_sequence
MAEERPGAWFGFGFCGFGQELGSGRGRQVHSPSPLRAGVDICRVSASWSYTAFVTRGGRLELSGSASGAAGRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYAVEKGKS
uniprot
proteins
function
FUNCTION: Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8 (PubMed:24981860). Possibly together with KDM8, is involved in proper mitotic spindle organization and chromosome segregation (PubMed:24981860). Plays a role in regulating alpha-tubulin deacetylation and cytoskeletal microtubule stability, thereby promoting cell migration and TGF-beta-induced epithelial to mesenchymal transition (EMT), potentially through the inhibition of KDM8 (PubMed:28455245). {ECO:0000269|PubMed:24981860, ECO:0000269|PubMed:28455245}.
uniprot
proteins
mass_dalton
40079
uniprot
proteins
mutagenesis
MUTAGEN 141; /note="R->A: Abolishes hydroxylation by KDM8."; /evidence="ECO:0000269|PubMed:29563586
uniprot
proteins
post_translational_modification
PTM: Specifically hydroxylated (with R stereochemistry) at C-3 of ARG-141 by KDM8. {ECO:0000269|PubMed:29563586}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24981860
uniprot
proteins
pubmed
28455245
uniprot
proteins
pubmed
28982940
uniprot
proteins
pubmed
29563586
uniprot
proteins
sequence_length
376
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:24981860}. Note=Colocalizes with trimethylated 'Lys-9' of histone H3 (H3K9me3). {ECO:0000269|PubMed:24981860}.
uniprot
proteins