CDCA2
entrez
157313
canonical
uniprot
Q69YH5
canonical
ensembl
ENSG00000184661
resolver
ensp
ENSP00000328228
resolver
ensp
ENSP00000370040
resolver
enst
ENST00000380665
resolver
genesymbol
CDCA2
resolver
hgnc
HGNC:14623
resolver
uniprot
A8K8Z0
resolver
uniprot
B7Z5Q5
resolver
uniprot
E9PEI0
resolver
uniprot
Q3SX74
resolver
uniprot
Q4G0W0
resolver
uniprot
Q5RKN0
resolver
uniprot
Q69YI4
resolver
uniprot
Q6P464
resolver
uniprot
Q8N7C1
resolver
uniprot_entry
A8K8Z0_HUMAN
resolver
uniprot_entry
B7Z5Q5_HUMAN
resolver
uniprot_entry
CDCA2_HUMAN
resolver
uniprot_entry
E9PEI0_HUMAN
resolver
uniprot_sec
Q3SX74
resolver
uniprot_sec
Q4G0W0
resolver
uniprot_sec
Q5RKN0
resolver
uniprot_sec
Q69YI4
resolver
uniprot_sec
Q6P464
resolver
uniprot_sec
Q8N7C1
resolver
amino_acid_sequence
MDANSKDKPPETKESAMNNAGNASFILGTGKIVTPQKHAELPPNPCTPDTFKSPLNFSTVTVEQLGITPESFVRNSAGKSSSYLKKCRRRSAVGARGSPETNHLIRFIARQQNIKNARKSPLAQDSPSQGSPALYRNVNTLRERISAFQSAFHSIKENEKMTGCLEFSEAGKESEMTDLTRKEGLSACQQSGFPAVLSSKRRRISYQRDSDENLTDAEGKVIGLQIFNIDTDRACAVETSVDLSEISSKLGSTQSGFLVEESLPLSELTETSNALKVADCVVGKGSSDAVSPDTFTAEVSSDAVPDVRSPATPACRRDLPTPKTFVLRSVLKKPSVKMCLESLQEHCNNLYDDDGTHPSLISNLPNCCKEKEAEDEENFEAPAFLNMRKRKRVTFGEDLSPEVFDESLPANTPLRKGGTPVCKKDFSGLSSLLLEQSPVPEPLPQPDFDDKGENLENIEPLQVSFAVLSSPNKSSISETLSGTDTFSSSNNHEKISSPKVGRITRTSNRRNQLVSVVEESVCNLLNTEVQPCKEKKINRRKSQETKCTKRALPKKSQVLKSCRKKKGKGKKSVQKSLYGERDIASKKPLLSPIPELPEVPEMTPSIPSIRRLGSGYFSSNGKLEEVKTPKNPVKRKDLLRHDPDLHMHQGYDKYDVSEFCSYIKSSSSLGNATSDEDPNTNIMNINENKNIPKAKNKSESENEPKAGTDSPVSCASVTEERVASDSPKPALTLQQGQEFSAGGQNAENLCQFFKISPDLNIKCERKDDFLGAAEGKLQCNRLMPNSQKDCHCLGDVLIENTKESKSQSEDLGRKPMESSSVVSCRDRKDRRRSMCYSDGRSLHLEKNGNHTPSSSVGSSVEISLENSELFKDLSDAIEQTFQRRNSETKVRRSTRLQKDLENEGLVWISLPLPSTSQKAKRRTICTFDSSGFESMSPIKETVSSRQKPQMAPPVSDPENSQGPAAGSSDEPGKRRKSFCISTLANTKATSQFKGYRRRSSLNGKGESSLTALERIEHNGERKQ
uniprot
proteins
function
FUNCTION: Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phosphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. {ECO:0000269|PubMed:16492807, ECO:0000269|PubMed:16998479}.
uniprot
proteins
mass_dalton
112676
uniprot
proteins
mutagenesis
MUTAGEN 393..395; /note="VTF->ATA: Abolishes interaction with PPP1CC but not subcellular location."; /evidence="ECO:0000269|PubMed:16492807
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CDK1. May regulate its subcellular location. {ECO:0000269|PubMed:16998479}.
uniprot
proteins
pubmed
12188893
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
16492807
uniprot
proteins
pubmed
16998479
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
1023
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16492807}. Note=Excluded from the nucleolus. Present in nucleoplasm throughout the G1, S and G2 stages of the cell cycle. During M phase, it becomes diffuse throughout the cell as the nuclear membrane breaks down, and faintly accumulates later on metaphase chromatin. As the cell progresses to anaphase, it accumulates on chromatin.
uniprot
proteins