Pard6a
entrez
56513
canonical
uniprot
Q9Z101
canonical
ensembl
ENSMUSG00000005699
resolver
ensp
ENSMUSP00000090886
resolver
ensp
ENSMUSP00000096043
resolver
ensp
ENSMUSP00000148603
resolver
ensp
ENSMUSP00000148821
resolver
enst
ENSMUST00000098444
resolver
genesymbol
Pard6a
resolver
genesymbol_syn
Par6a
resolver
uniprot
D3Z2R1
resolver
uniprot
Q3TY70
resolver
uniprot
Q5RL03
resolver
uniprot
Q6P8R2
resolver
uniprot_entry
D3Z2R1_MOUSE
resolver
uniprot_entry
PAR6A_MOUSE
resolver
uniprot_entry
Q3TY70_MOUSE
resolver
uniprot_sec
Q5RL03
resolver
uniprot_sec
Q6P8R2
resolver
amino_acid_sequence
MARPQRTPARSPDSIVEVKSKFDAEFRRFALPRTSVRGFQEFSRLLCVVHQIPGLDVLLGYTDAHGDLLPLTNDDSLHRALASGPPPLRLLVQKRAEGDSSGLAFASNSLQRRKKGLLLRPVAPLRTRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTVKPANQRNNVVRGASGRLTGPSSVGPGPTDPDSDDDSSDLVIENRHPPCSNGLSQGPLCWDLQPGCLLPGAGSSLPSLDSREQANSGWGNGMRGDVSGFSL
uniprot
proteins
function
FUNCTION: Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:15761148). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (By similarity). {ECO:0000250|UniProtKB:Q9NPB6, ECO:0000269|PubMed:15761148}.
uniprot
proteins
mass_dalton
37333
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by the TGF-beta receptor. {ECO:0000269|PubMed:15761148}.; PTM: Ubiquitinated by the SCF(FBXO31) complex, leading to its proteasomal degradation. {ECO:0000250|UniProtKB:Q9NPB6}.
uniprot
proteins
protein_family
PAR6 family
uniprot
proteins
pubmed
10934475
uniprot
proteins
pubmed
12629547
uniprot
proteins
pubmed
12813044
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15761148
uniprot
proteins
pubmed
9834192
uniprot
proteins
sequence_length
346
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Cell junction, tight junction {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000250|UniProtKB:Q9NPB6}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9NPB6}. Note=Colocalizes with GTP-bound CDC42 or RAC1 at membrane ruffles and with PARD3 at epithelial tight junctions. Recruited to the centrosome by a microtubule and dynein-dynactin-dependent mechanism. {ECO:0000250|UniProtKB:Q9NPB6}.
uniprot
proteins