CIAO2B
entrez
51647
canonical
uniprot
Q9Y3D0
canonical
ensembl
ENSG00000166595
resolver
ensp
ENSP00000387471
resolver
enst
ENST00000422424
resolver
genesymbol
CIAO2B
resolver
genesymbol_syn
CIAB
resolver
genesymbol_syn
FAM96B
resolver
genesymbol_syn
MIP18
resolver
hgnc
HGNC:24261
resolver
uniprot_entry
CIA2B_HUMAN
resolver
amino_acid_sequence
MVGGGGVGGGLLENANPLIYQRSGERPVTAGEEDEQVPDSIDAREIFDLIRSINDPEHPLTLEELNVVEQVRVQVSDPESTVAVAFTPTIPHCSMATLIGLSIKVKLLRSLPQRFKMDVHITPGTHASEHAVNKQLADKERVAAALENTHLLEVVNQCLSARS
uniprot
proteins
function
FUNCTION: Component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins (PubMed:22678361, PubMed:22678362, PubMed:23891004, PubMed:29848660). As a CIA complex component and in collaboration with CIAO1 and MMS19, binds to and facilitates the assembly of most cytosolic-nuclear Fe/S proteins (PubMed:23891004, PubMed:29848660). As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD (PubMed:20797633). Together with MMS19, facilitates the transfer of Fe-S clusters to the motor protein KIF4A, which ensures proper localization of KIF4A to mitotic machinery components to promote the progression of mitosis (PubMed:29848660). {ECO:0000269|PubMed:20797633, ECO:0000269|PubMed:22678361, ECO:0000269|PubMed:22678362, ECO:0000269|PubMed:23891004, ECO:0000269|PubMed:29848660}.
uniprot
proteins
mass_dalton
17663
uniprot
proteins
protein_family
MIP18 family
uniprot
proteins
pubmed
10810093
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20797633
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22678361
uniprot
proteins
pubmed
22678362
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23585563
uniprot
proteins
pubmed
23891004
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29320706
uniprot
proteins
pubmed
29848660
uniprot
proteins
pubmed
30742009
uniprot
proteins
sequence_length
163
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20797633}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:20797633, ECO:0000269|PubMed:29848660}. Midbody {ECO:0000269|PubMed:29848660}. Note=In mitosis, localizes to the spindle during metaphase and the spindle midbody during telophase (PubMed:29848660). Co-localizes with KIF4A to the spindle midzone and midbody during telophase and cytokinesis (PubMed:29848660). {ECO:0000269|PubMed:29848660}.
uniprot
proteins