Hsd17b6
entrez
286964
canonical
uniprot
O54753
canonical
ensembl
ENSRNOG00000002597
resolver
ensp
ENSRNOP00000094822
resolver
ensp
ENSRNOP00000110093
resolver
genesymbol
Hsd17b6
resolver
genesymbol_syn
Hsd17b9
resolver
uniprot
Q5M8C8
resolver
uniprot_entry
H17B6_RAT
resolver
uniprot_sec
Q5M8C8
resolver
activity_regulation
ACTIVITY REGULATION: Competitively inhibited by 9-cis-retinoic acid and 13-cis-retinoic acid. {ECO:0000269|PubMed:9188497}.
uniprot
proteins
amino_acid_sequence
MWFYLVTLVGLYYLLRWYRERQVVSHLHDKYVFITGCDSGFGNLLARQLDRRGMRVLAACLTEKGAEELKSKTSDRLETVILDVTNTDSISAATQWVKEHVGDKGLWGLVNNAGVFQAFAYIEWCRPEDCMSIFQVNLIGLAQVTLSMLFLVKKARGRIVNVSSVLGRVALFGGFYSCSKYGVEAFSDVLRREIRDFGVKVSIIEPGSFKTRMTDAELIIEKTKKTWEATPEHIRESYGQQFFDDFCNTTRRELKKCSTNLSLVTDCMEHALTSKYPRTRYSAGWDARLFFIPLSYLPTSLVDCLLAISRRKPAQAV
uniprot
proteins
ec_number
1.1.1.105
uniprot
proteins
ec_number
1.1.1.209
uniprot
proteins
ec_number
1.1.1.239
uniprot
proteins
ec_number
1.1.1.53
uniprot
proteins
ec_number
1.1.1.62
uniprot
proteins
function
FUNCTION: NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro) (By similarity). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). {ECO:0000250|UniProtKB:O14756, ECO:0000269|PubMed:9188497}.
uniprot
proteins
mass_dalton
36145
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9188497
uniprot
proteins
sequence_length
317
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000250|UniProtKB:O14756}; Peripheral membrane protein {ECO:0000250|UniProtKB:O14756}; Lumenal side {ECO:0000250|UniProtKB:O14756}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O14756}; Peripheral membrane protein {ECO:0000250|UniProtKB:O14756}; Lumenal side {ECO:0000250|UniProtKB:O14756}.
uniprot
proteins