Tnf
entrez
21926
canonical
uniprot
P06804
canonical
ensembl
ENSMUSG00000024401
resolver
ensp
ENSMUSP00000025263
resolver
ensp
ENSMUSP00000126122
resolver
enst
ENSMUST00000025263
resolver
enst
ENSMUST00000167924
resolver
genesymbol
Tnf
resolver
genesymbol_syn
Tnfa
resolver
genesymbol_syn
Tnfsf2
resolver
uniprot
A0A0R4J210
resolver
uniprot
O35853
resolver
uniprot
Q3U593
resolver
uniprot
Q62326
resolver
uniprot
Q91VF3
resolver
uniprot_entry
A0A0R4J210_MOUSE
resolver
uniprot_entry
Q3U593_MOUSE
resolver
uniprot_entry
TNFA_MOUSE
resolver
uniprot_sec
O35853
resolver
uniprot_sec
Q62326
resolver
uniprot_sec
Q91VF3
resolver
amino_acid_sequence
MSTESMIRDVELAEEALPQKMGGFQNSRRCLCLSLFSFLLVAGATTLFCLLNFGVIGPQRDEKFPNGLPLISSMAQTLTLRSSSQNSSDKPVAHVVANHQVEEQLEWLSQRANALLANGMDLKDNQLVVPADGLYLVYSQVLFKGQGCPDYVLLTHTVSRFAISYQEKVNLLSAVKSPCPKDTPEGAELKPWYEPIYLGGVFQLEKGDQLSAEVNLPKYLDFAESGQVYFGVIAL
uniprot
proteins
function
FUNCTION: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces GKAP42 protein degradation in adipocytes which is partially responsible for TNF-induced insulin resistance (PubMed:25586176). Plays a role in angiogenesis by inducing VEGF production synergistically with IL1B and IL6 (By similarity). Promotes osteoclastogenesis and therefore mediates bone resorption (PubMed:32741026). {ECO:0000250|UniProtKB:P01375, ECO:0000269|PubMed:25586176, ECO:0000269|PubMed:32741026}.; FUNCTION: The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells. {ECO:0000250|UniProtKB:P01375}.
uniprot
proteins
mass_dalton
25896
uniprot
proteins
post_translational_modification
PTM: The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space (By similarity). The soluble form derives from the membrane form by proteolytic processing. {ECO:0000250}.; PTM: The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1 (By similarity). {ECO:0000250}.; PTM: O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid. {ECO:0000250}.; PTM: [Tumor necrosis factor, soluble form]: The soluble form is demyristoylated by SIRT6, promoting its secretion. {ECO:0000250|UniProtKB:P01375}.
uniprot
proteins
protein_family
Tumor necrosis factor family
uniprot
proteins
pubmed
10089307
uniprot
proteins
pubmed
14656967
uniprot
proteins
pubmed
2268312
uniprot
proteins
pubmed
2419912
uniprot
proteins
pubmed
25586176
uniprot
proteins
pubmed
2777790
uniprot
proteins
pubmed
2836146
uniprot
proteins
pubmed
2989794
uniprot
proteins
pubmed
3040015
uniprot
proteins
pubmed
32741026
uniprot
proteins
pubmed
3349526
uniprot
proteins
pubmed
3684584
uniprot
proteins
pubmed
3898078
uniprot
proteins
pubmed
7560085
uniprot
proteins
pubmed
9089109
uniprot
proteins
sequence_length
235
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein.; SUBCELLULAR LOCATION: [Tumor necrosis factor, membrane form]: Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Tumor necrosis factor, soluble form]: Secreted.; SUBCELLULAR LOCATION: [C-domain 1]: Secreted {ECO:0000250}.; SUBCELLULAR LOCATION: [C-domain 2]: Secreted {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..56; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins