MEF2D
entrez
4209
canonical
uniprot
Q14814
canonical
ensembl
ENSG00000116604
resolver
ensembl
ENSG00000291761
resolver
ensp
ENSP00000271555
resolver
ensp
ENSP00000353803
resolver
ensp
ENSP00000476788
resolver
ensp
ENSP00000545484
resolver
ensp
ENSP00000545485
resolver
ensp
ENSP00000594833
resolver
ensp
ENSP00000594836
resolver
ensp
ENSP00000594838
resolver
ensp
ENSP00000640851
resolver
ensp
ENSP00000640852
resolver
ensp
ENSP00000640867
resolver
ensp
ENSP00000640870
resolver
ensp
ENSP00000640876
resolver
genesymbol
MEF2D
resolver
hgnc
HGNC:6997
resolver
uniprot
D3DVC0
resolver
uniprot
Q14815
resolver
uniprot
Q5T9U5
resolver
uniprot
Q5T9U6
resolver
uniprot_entry
MEF2D_HUMAN
resolver
uniprot_sec
D3DVC0
resolver
uniprot_sec
Q14815
resolver
uniprot_sec
Q5T9U5
resolver
uniprot_sec
Q5T9U6
resolver
amino_acid_sequence
MGRKKIQIQRITDERNRQVTFTKRKFGLMKKAYELSVLCDCEIALIIFNHSNKLFQYASTDMDKVLLKYTEYNEPHESRTNADIIETLRKKGFNGCDSPEPDGEDSLEQSPLLEDKYRRASEELDGLFRRYGSTVPAPNFAMPVTVPVSNQSSLQFSNPSGSLVTPSLVTSSLTDPRLLSPQQPALQRNSVSPGLPQRPASAGAMLGGDLNSANGACPSPVGNGYVSARASPGLLPVANGNSLNKVIPAKSPPPPTHSTQLGAPSRKPDLRVITSQAGKGLMHHLTEDHLDLNNAQRLGVSQSTHSLTTPVVSVATPSLLSQGLPFSSMPTAYNTDYQLTSAELSSLPAFSSPGGLSLGNVTAWQQPQQPQQPQQPQPPQQQPPQPQQPQPQQPQQPQQPPQQQSHLVPVSLSNLIPGSPLPHVGAALTVTTHPHISIKSEPVSPSRERSPAPPPPAVFPAARPEPGDGLSSPAGGSYETGDRDDGRGDFGPTLGLLRPAPEPEAEGSAVKRMRLDTWTLK
uniprot
proteins
function
FUNCTION: Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). {ECO:0000250, ECO:0000269|PubMed:10849446, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:15834131}.
uniprot
proteins
mass_dalton
55938
uniprot
proteins
mutagenesis
MUTAGEN 180; /note="S->A: Abolishes MAPK7- and EGF-mediated transcriptional activation."; /evidence="ECO:0000269|PubMed:10849446"; MUTAGEN 286; /note="T->A: Same transcriptional activity as for isoforms with beta domain."; /evidence="ECO:0000269|PubMed:15834131"; MUTAGEN 287; /note="E->Q: Abolishes transcriptional activity; when associated with N-288 and N-291."; /evidence="ECO:0000269|PubMed:15834131"; MUTAGEN 288; /note="D->A: Abolishes cleavage by caspase 7."; /evidence="ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:15834131"; MUTAGEN 288; /note="D->N: Abolishes transcriptional activity; when associated with Q-287 and N-291."; /evidence="ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:15834131"; MUTAGEN 289; /note="H->A: Same transcriptional activity as for isoforms with beta domain."; /evidence="ECO:0000269|PubMed:15834131"; MUTAGEN 291; /note="D->N: Abolishes transcriptional activity; when associated with Q-287 and N-288."; /evidence="ECO:0000269|PubMed:15834131"; MUTAGEN 437; /note="S->A: No effect on MAPK7- or EGF-mediated transcriptional activity."; /evidence="ECO:0000269|PubMed:10849446"; MUTAGEN 438; /note="I->A: Abolishes K-439 sumoylation."; /evidence="ECO:0000269|PubMed:16166628"; MUTAGEN 439; /note="K->R: Abolishes sumoylation and acetylation."; /evidence="ECO:0000269|PubMed:16166628, ECO:0000269|PubMed:16356933"; MUTAGEN 444; /note="S->A: Abolishes K-439 sumoylation. Reduced neurotoxin-induced apoptosis of neuronal cells. More resistant to degradation."; /evidence="ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15888658, ECO:0000269|PubMed:16356933"; MUTAGEN 444; /note="S->E: No effect on K-439 sumoylation."; /evidence="ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15888658, ECO:0000269|PubMed:16356933
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser-444 by CDK5 is required for Lys-439 sumoylation and inhibits transcriptional activity. In neurons, enhanced CDK5 activity induced by neurotoxins promotes caspase 3-mediated cleavage leading to neuron apoptosis. Phosphorylation on Ser-180 can be enhanced by EGF. Phosphorylated and activated by CaMK4. {ECO:0000269|PubMed:10617605, ECO:0000269|PubMed:10849446, ECO:0000269|PubMed:11904443, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:15888658, ECO:0000269|PubMed:16166628, ECO:0000269|PubMed:16356933}.; PTM: Acetylated on Lys-439 by CREBBP. Acetylated by EP300. Deacetylated by SIRT1 and HDAC3. {ECO:0000269|PubMed:15831463, ECO:0000269|PubMed:16166628, ECO:0000269|PubMed:21030595}.; PTM: Sumoylated on Lys-439 with SUMO2 but not SUMO1; which inhibits transcriptional activity and myogenic activity. Desumoylated by SENP3. {ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:16166628, ECO:0000269|PubMed:16356933}.; PTM: Proteolytically cleaved in cerebellar granule neurons on several sites by caspase 7 following neurotoxicity. Preferentially cleaves the CDK5-mediated hyperphosphorylated form which leads to neuron apoptosis and transcriptional inactivation (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
MEF2 family
uniprot
proteins
pubmed
10523670
uniprot
proteins
pubmed
10617605
uniprot
proteins
pubmed
10849446
uniprot
proteins
pubmed
11904443
uniprot
proteins
pubmed
12691662
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15743823
uniprot
proteins
pubmed
15831463
uniprot
proteins
pubmed
15834131
uniprot
proteins
pubmed
15888658
uniprot
proteins
pubmed
16166628
uniprot
proteins
pubmed
16356933
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21030595
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8269842
uniprot
proteins
pubmed
9858528
uniprot
proteins
sequence_length
521
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00251, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15743823}. Note=Translocated by HDAC4 to nuclear dots.
uniprot
proteins