PIGBOS1
entrez
101928527
canonical
uniprot
A0A0B4J2F0
canonical
ensembl
ENSG00000225973
resolver
ensp
ENSP00000482636
resolver
ensp
ENSP00000484893
resolver
ensp
ENSP00000528509
resolver
ensp
ENSP00000528510
resolver
ensp
ENSP00000589611
resolver
ensp
ENSP00000589612
resolver
enst
ENST00000436697
resolver
enst
ENST00000567948
resolver
enst
ENST00000858450
resolver
enst
ENST00000858451
resolver
enst
ENST00000919552
resolver
enst
ENST00000919553
resolver
genesymbol
PIGBOS1
resolver
hgnc
HGNC:50696
resolver
uniprot_entry
PIOS1_HUMAN
resolver
amino_acid_sequence
MFRRLTFAQLLFATVLGIAGGVYIFQPVFEQYAKDQKELKEKMQLVQESEEKKS
uniprot
proteins
function
FUNCTION: Plays a role in regulation of the unfolded protein response triggered by endoplasmic reticulum (ER) stress resulting from the presence of unfolded proteins in the ER lumen. {ECO:0000269|PubMed:31653868}.
uniprot
proteins
mass_dalton
6313
uniprot
proteins
mutagenesis
MUTAGEN 30..32; /note="EQY->AAA: Does not affect mitochondrial location but reduces interaction with CLCC1."; /evidence="ECO:0000269|PubMed:31653868"; MUTAGEN 34..36; /note="KDQ->AAA: Does not affect mitochondrial location but reduces interaction with CLCC1."; /evidence="ECO:0000269|PubMed:31653868"; MUTAGEN 37..39; /note="KEL->AAA: Does not affect mitochondrial location or interaction with CLCC1."; /evidence="ECO:0000269|PubMed:31653868"; MUTAGEN 40..42; /note="KEK->AAA: Does not affect mitochondrial location or interaction with CLCC1."; /evidence="ECO:0000269|PubMed:31653868"; MUTAGEN 43..45; /note="MQL->AAA: Does not affect mitochondrial location or interaction with CLCC1."; /evidence="ECO:0000269|PubMed:31653868"; MUTAGEN 46..48; /note="VQE->AAA: Does not affect mitochondrial location or interaction with CLCC1."; /evidence="ECO:0000269|PubMed:31653868"; MUTAGEN 49..51; /note="SEE->AAA: Does not affect mitochondrial location or interaction with CLCC1."; /evidence="ECO:0000269|PubMed:31653868"; MUTAGEN 52..54; /note="KKS->AAA: Does not affect mitochondrial location or interaction with CLCC1."; /evidence="ECO:0000269|PubMed:31653868
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
31653868
uniprot
proteins
sequence_length
54
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:31653868}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..25; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins