Mfn2
entrez
170731
canonical
uniprot
Q80U63
canonical
ensembl
ENSMUSG00000029020
resolver
ensp
ENSMUSP00000030884
resolver
ensp
ENSMUSP00000101340
resolver
ensp
ENSMUSP00000101341
resolver
ensp
ENSMUSP00000313968
resolver
ensp
ENSMUSP00000313969
resolver
ensp
ENSMUSP00000313972
resolver
ensp
ENSMUSP00000313976
resolver
ensp
ENSMUSP00000313987
resolver
ensp
ENSMUSP00000314017
resolver
ensp
ENSMUSP00000314059
resolver
ensp
ENSMUSP00000314060
resolver
ensp
ENSMUSP00000314068
resolver
ensp
ENSMUSP00000314076
resolver
genesymbol
Mfn2
resolver
genesymbol_syn
Kiaa0214
resolver
genesymbol_syn
Marf
resolver
uniprot
A2A7Y7
resolver
uniprot
A8Y5E4
resolver
uniprot
Q3V3B8
resolver
uniprot
Q80WP4
resolver
uniprot
Q80XK3
resolver
uniprot
Q8BHF0
resolver
uniprot
Q8BKV5
resolver
uniprot
Q8R535
resolver
uniprot
Q923X2
resolver
uniprot_entry
MFN2_MOUSE
resolver
uniprot_sec
A2A7Y7
resolver
uniprot_sec
A8Y5E4
resolver
uniprot_sec
Q3V3B8
resolver
uniprot_sec
Q80WP4
resolver
uniprot_sec
Q80XK3
resolver
uniprot_sec
Q8BHF0
resolver
uniprot_sec
Q8BKV5
resolver
uniprot_sec
Q8R535
resolver
uniprot_sec
Q923X2
resolver
amino_acid_sequence
MSLLFSRCNSIVTVKKDKRHMAEVNASPLKHFVTAKKKINGIFEQLGAYIQESASFLEDTHRNTELDPVTTEEQVLDVKGYLSKVRGISEVLARRHMKVAFFGRTSNGKSTVINAMLWDKVLPSGIGHTTNCFLRVGGTDGHEAFLLTEGSEEKKSVKTVNQLAHALHQDEQLHAGSMVSVMWPNSKCPLLKDDLVLMDSPGIDVTTELDSWIDKFCLDADVFVLVANSESTLMQTEKQFFHKVSERLSRPNIFILNNRWDASASEPEYMEEVRRQHMERCTSFLVDELGVVDRAQAGDRIFFVSAKEVLSARVQKAQGMPEGGGALAEGFQVRMFEFQNFERQFEECISQSAVKTKFEQHTVRAKQIAEAVRLIMDSLHIAAQEQRVYCLEMREERQDRLRFIDKQLELLAQDYKLRIKQITEEVERQVSTAMAEEIRRLSVLVDEYQMDFHPSPVVLKVYKNELHRHIEEGLGRNLSDRCSTAIASSLQTMQQDMIDGLKPLLPVSMRNQIDMLVPRQCFSLSYDLNCDKLCADFQEDIEFHFSLGWTMLVNRFLGPKNSRRALLGYSDQVQRPLPLTPANPSMPPLPQSSLTQEELMVSMVTGLASLTSRTSMGILVVGGVVWKAVGWRLIALSFGLYGLLYVYERLTWTTKAKERAFKRQFVEYASEKLQLIISYTGSNCSHQVQQELSGTFAHLCQQVDITRDNLEQEIAAMNKKVEALDSLQSRAKLLRNKAGWLDSELNMFTHQYLQPSR
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion (PubMed:12527753, PubMed:23620051, PubMed:23921378). Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks. Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (By similarity). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PRKN recruitment to dysfunctional mitochondria (PubMed:23620051). Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (PubMed:23921556). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions (PubMed:23921556). {ECO:0000250|UniProtKB:O95140, ECO:0000250|UniProtKB:Q8R500, ECO:0000269|PubMed:12527753, ECO:0000269|PubMed:23620051, ECO:0000269|PubMed:23921378, ECO:0000269|PubMed:23921556}.
uniprot
proteins
mass_dalton
86188
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PINK1. {ECO:0000269|PubMed:23620051}.; PTM: Ubiquitinated by non-degradative ubiquitin by PRKN, promoting mitochondrial fusion; deubiquitination by USP30 inhibits mitochondrial fusion (PubMed:23620051, PubMed:24513856). Ubiquitinated by HUWE1 when dietary stearate (C18:0) levels are low; ubiquitination inhibits mitochondrial fusion (By similarity). {ECO:0000250|UniProtKB:O95140, ECO:0000269|PubMed:23620051, ECO:0000269|PubMed:24513856}.
uniprot
proteins
protein_family
Dynamin/Fzo/YdjA family
uniprot
proteins
protein_family
Mitofusin subfamily
uniprot
proteins
protein_family
TRAFAC class dynamin-like GTPase superfamily
uniprot
proteins
pubmed
11950885
uniprot
proteins
pubmed
12527753
uniprot
proteins
pubmed
12598526
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15322553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23620051
uniprot
proteins
pubmed
23921378
uniprot
proteins
pubmed
23921556
uniprot
proteins
pubmed
24513856
uniprot
proteins
sequence_length
757
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:O95140}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O95140}. Note=Colocalizes with BAX during apoptosis. {ECO:0000250|UniProtKB:O95140}.
uniprot
proteins
transmembrane_region
TRANSMEM 605..625; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 627..647; /note="Helical; Name=2"; /evidence="ECO:0000255
uniprot
proteins