Alcam
entrez
79559
canonical
uniprot
O35112
canonical
ensembl
ENSRNOG00000001989
resolver
ensp
ENSRNOP00000002738
resolver
ensp
ENSRNOP00000080494
resolver
enst
ENSRNOT00000002738
resolver
enst
ENSRNOT00000104562
resolver
genesymbol
Alcam
resolver
uniprot
A0A8I5ZQS5
resolver
uniprot
A0A8L2UHD3
resolver
uniprot
O55172
resolver
uniprot_entry
A0A8I5ZQS5_RAT
resolver
uniprot_entry
A0A8L2UHD3_RAT
resolver
uniprot_entry
CD166_RAT
resolver
uniprot_sec
O55172
resolver
amino_acid_sequence
MASKGSPSCRLVFCLLISAAVLRPGLGWYTVNSAYGDTIVMPCRLDVPQNLMFGKWKYEKPDGSPVFIAFRSSTKKSVQYDDVPEYKDRLSLSENYTLSINNAKISDEKRFVCMLVTEDNVFEAPTLVKVFKQPSKPEIVNRAAFLETEQLKKLGDCISRDSYPDGNITWYRNGKVLQPVDGEVSILFKKEIDPGTQLYTMTSSLEYKTTKSDIQMPFTCSVTYYGPSGQKTIYSEQAIFDIYYPTEQVTIQVLPPKNAIKEGDNITLQCLGNGNPPPEEFMFYLPGQAEGIRSSNTYTLTDVRRNATGDYKCSLIDQRNMAASTTITVHYLDLSLNPSGEVTKQIGDTLPVSCTISASRNATVVWMKDNIRLRSSPSFSSLHYQDAGNYVCETALQEVEGLKKRESLTLIVEGKPQIKMTKKTDPSGLSKTIICHVEGFPKPAIQWTITGSGSVINQTEESPYINGRYYSKIIISPEENVTLTCTAENQLERTVNSLNVSAISIPEHDEADDISDENREKVNDQAKLIVGIVVGLLLAALVAGVVYWLYMKKSKTASKHVNKDLGNMEENKKLEENNHKTEA
uniprot
proteins
function
FUNCTION: Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity). Mediates homotypic interactions with cells that express ALCAM. Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions. Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM (By similarity). Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity). {ECO:0000250|UniProtKB:P42292, ECO:0000250|UniProtKB:Q13740, ECO:0000250|UniProtKB:Q61490}.
uniprot
proteins
mass_dalton
65022
uniprot
proteins
post_translational_modification
PTM: The N-terminus is blocked.; PTM: Glycosylated. {ECO:0000250|UniProtKB:Q13740}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24090084
uniprot
proteins
pubmed
8004458
uniprot
proteins
pubmed
9201982
uniprot
proteins
pubmed
9556065
uniprot
proteins
sequence_length
583
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q61490}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q61490}. Cell projection, axon {ECO:0000250|UniProtKB:Q61490}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q61490}. Note=Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells. Colocalizes with CD6 and the TCR/CD3 complex at the immunological synapse. {ECO:0000250|UniProtKB:Q13740}.
uniprot
proteins
transmembrane_region
TRANSMEM 528..549; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins