Fam89b
entrez
17826
canonical
uniprot
Q9QUI1
canonical
ensembl
ENSMUSG00000024939
resolver
ensp
ENSMUSP00000097538
resolver
ensp
ENSMUSP00000124294
resolver
genesymbol
Fam89b
resolver
genesymbol_syn
C184m
resolver
genesymbol_syn
Lrap25
resolver
genesymbol_syn
Mtvr2
resolver
uniprot
Q7TMI7
resolver
uniprot
Q8K2S5
resolver
uniprot
Q9JHD8
resolver
uniprot
Q9JL54
resolver
uniprot_entry
LRA25_MOUSE
resolver
uniprot_entry
Q7TMI7_MOUSE
resolver
uniprot_sec
Q8K2S5
resolver
uniprot_sec
Q9JHD8
resolver
uniprot_sec
Q9JL54
resolver
amino_acid_sequence
MNGLPATEAPGGAGCALAGLPPLPRGLSGLLNASGGSWRELERVYSQRSRIHDELSRAARAPDGPRHAAGSANSGSAAGPRRPVNLDSALAALRKEMVGLRQLDMSLLCQLWGLYESIQDYKHLCQDLSLCQDLSSSLHSDSSYPPDAGLSDDEEPPDASLPPDPPPLTVPQTHNARDQWLQDAFQISL
uniprot
proteins
function
FUNCTION: Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta (PubMed:12646588). Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (PubMed:25107909). {ECO:0000269|PubMed:12646588, ECO:0000269|PubMed:25107909}.; FUNCTION: [Isoform 2]: (Microbial infection) May be a receptor for mouse mammary tumor virus (MMTV). {ECO:0000269|PubMed:9525630}.
uniprot
proteins
mass_dalton
20140
uniprot
proteins
protein_family
FAM89 family
uniprot
proteins
pubmed
10512749
uniprot
proteins
pubmed
12646588
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25107909
uniprot
proteins
pubmed
9525630
uniprot
proteins
sequence_length
189
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:12646588}. Cell projection, lamellipodium {ECO:0000269|PubMed:25107909}. Note=Co-localizes with CDC42BPA, CDC42BPB and LIMK1 in the lamellipodium. {ECO:0000269|PubMed:25107909}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell surface {ECO:0000269|PubMed:9525630}.
uniprot
proteins