Rcc2
entrez
108911
canonical
uniprot
Q8BK67
canonical
ensembl
ENSMUSG00000040945
resolver
ensp
ENSMUSP00000038144
resolver
ensp
ENSMUSP00000071163
resolver
ensp
ENSMUSP00000173532
resolver
enst
ENSMUST00000038893
resolver
enst
ENSMUST00000071169
resolver
genesymbol
Rcc2
resolver
genesymbol_syn
Kiaa1470
resolver
uniprot
A2AWQ3
resolver
uniprot
Q6ZPQ0
resolver
uniprot_entry
RCC2_MOUSE
resolver
uniprot_sec
A2AWQ3
resolver
uniprot_sec
Q6ZPQ0
resolver
amino_acid_sequence
MPRKKGAAWEEPSSGNGTARAGPRRRGGPAGRKRERPERCSSSSGGGSSGDEDGPELDGAPGGGKRTARPATAGKAAGAAAIITEPEHTKERVKLEGSKCKGQLLIFGATNWDLIGRKEVPKQQAAYRNLGQNLWGPHRYGCLSGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEALSHEAIVLAACGRNHTLALTDTGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMLMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGATQIYAGYTCSFAVSEVGGLFFWGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARDESEAEKEKLQRLPEYTPRTL
uniprot
proteins
function
FUNCTION: Multifunctional protein that may affect its functions by regulating the activity of small GTPases, such as RAC1 and RALA. Required for normal progress through the cell cycle, both during interphase and during mitosis. Required for the presence of normal levels of MAD2L1, AURKB and BIRC5 on inner centromeres during mitosis, and for normal attachment of kinetochores to mitotic spindles. Required for normal organization of the microtubule cytoskeleton in interphase cells. Functions as a guanine nucleotide exchange factor (GEF) for RALA. Interferes with the activation of RAC1 by guanine nucleotide exchange factors (By similarity). Prevents accumulation of active, GTP-bound RAC1, and suppresses RAC1-mediated reorganization of the actin cytoskeleton and formation of membrane protrusions (PubMed:25074804). Required for normal cellular responses to contacts with the extracellular matrix of adjacent cells, and for directional cell migration in response to a fibronectin gradient (in vitro) (By similarity). {ECO:0000250|UniProtKB:Q9P258, ECO:0000269|PubMed:25074804}.
uniprot
proteins
mass_dalton
55983
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
25074804
uniprot
proteins
pubmed
28869598
uniprot
proteins
sequence_length
520
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9P258}. Nucleus {ECO:0000250|UniProtKB:Q9P258}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9P258}. Chromosome, centromere {ECO:0000250|UniProtKB:Q9P258}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9P258}. Chromosome {ECO:0000250|UniProtKB:Q9P258}. Midbody {ECO:0000250|UniProtKB:Q9P258}. Cell membrane {ECO:0000250|UniProtKB:Q9P258}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9P258}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9P258}. Note=Appears in the nucleus at G2, then concentrates at the inner centromere region of chromosomes during prophase. Redistributes to the midzone of the mitotic spindle during anaphase. Here, the protein covers the entire equatorial diameter from cortex to cortex. Colocalizes with cytoplasmic microtubules in interphase cells. Colocalizes with RAC1 at the cell membrane. {ECO:0000250|UniProtKB:Q9P258}.
uniprot
proteins