ROBO2
entrez
6092
canonical
uniprot
Q9HCK4
canonical
ensembl
ENSG00000185008
resolver
ensp
ENSP00000327536
resolver
ensp
ENSP00000417164
resolver
ensp
ENSP00000417335
resolver
ensp
ENSP00000417471
resolver
ensp
ENSP00000418190
resolver
ensp
ENSP00000418446
resolver
ensp
ENSP00000512738
resolver
ensp
ENSP00000512766
resolver
ensp
ENSP00000512767
resolver
ensp
ENSP00000516193
resolver
enst
ENST00000332191
resolver
enst
ENST00000471893
resolver
enst
ENST00000475334
resolver
enst
ENST00000490534
resolver
enst
ENST00000696593
resolver
enst
ENST00000696629
resolver
enst
ENST00000696630
resolver
enst
ENST00000705983
resolver
genesymbol
ROBO2
resolver
genesymbol_syn
KIAA1568
resolver
hgnc
HGNC:10250
resolver
uniprot
A0A8Q3SIU0
resolver
uniprot
A0A8Q3SIW8
resolver
uniprot
A0A8Q3WLE3
resolver
uniprot
A0A994J7I9
resolver
uniprot
F8W703
resolver
uniprot
H7C4J7
resolver
uniprot
H7C4U9
resolver
uniprot
H7C4W9
resolver
uniprot
O43608
resolver
uniprot
Q19AB4
resolver
uniprot
Q19AB5
resolver
uniprot_entry
A0A8Q3SIU0_HUMAN
resolver
uniprot_entry
A0A8Q3SIW8_HUMAN
resolver
uniprot_entry
A0A8Q3WLE3_HUMAN
resolver
uniprot_entry
A0A994J7I9_HUMAN
resolver
uniprot_entry
F8W703_HUMAN
resolver
uniprot_entry
H7C4J7_HUMAN
resolver
uniprot_entry
H7C4U9_HUMAN
resolver
uniprot_entry
H7C4W9_HUMAN
resolver
uniprot_entry
ROBO2_HUMAN
resolver
uniprot_sec
O43608
resolver
uniprot_sec
Q19AB4
resolver
uniprot_sec
Q19AB5
resolver
amino_acid_sequence
MSLLMFTQLLLCGFLYVRVDGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWSAVLDVTESGATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIEAFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGLQATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQITDVVKQPAFIAGIGGACWVILMGFSIWLYWRRKKRKGLSNYAVTFQRGDGGLMSNGSRPGLLNAGDPSYPWLADSWPATSLPVNNSNSGPNEIGNFGRGDVLPPVPGQGDKTATMLSDGAIYSSIDFTTKTSYNSSSQITQATPYATTQILHSNSIHELAVDLPDPQWKSSIQQKTDLMGFGYSLPDQNKGNNGGKGGKKKKNKNSSKPQKNNGSTWANVPLPPPPVQPLPGTELEHYAVEQQENGYDSDSWCPPLPVQTYLHQGLEDELEEDDDRVPTPPVRGVASSPAISFGQQSTATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQSNNQPPQPPVPPLGYVSGALISDLETDVADDDADDEEEALEIPRPLRALDQTPGSSMDNLDSSVTGKAFTSSQRPRPTSPFSTDSNTSAALSQSQRPRPTKKHKGGRMDQQPALPHRREGMTDEEALVPYSKPSFPSPGGHSSSGTASSKGSTGPRKTEVLRAGHQRNASDLLDIGYMGSNSQGQFTGEL
uniprot
proteins
disease_involvement
DISEASE: Vesicoureteral reflux 2 (VUR2) [MIM:610878]: A disease belonging to the group of congenital anomalies of the kidney and urinary tract. It is characterized by the reflux of urine from the bladder into the ureters and sometimes into the kidneys, and is a risk factor for urinary tract infections. Primary disease results from a developmental defect of the ureterovesical junction. In combination with intrarenal reflux, the resulting inflammatory reaction may result in renal injury or scarring, also called reflux nephropathy. Extensive renal scarring impairs renal function and may predispose patients to hypertension, proteinuria, renal insufficiency and end-stage renal disease. {ECO:0000269|PubMed:17357069}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Note=A chromosomal aberration involving ROBO2 is a cause of multiple congenital abnormalities, including severe bilateral VUR with ureterovesical junction defects. Translocation t(Y;3)(p11;p12) with PCDH11Y. This translocation disrupts ROBO2 and produces dominant-negative ROBO2 proteins that abrogate SLIT-ROBO signaling in vitro.
uniprot
proteins
function
FUNCTION: Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development.
uniprot
proteins
mass_dalton
151200
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
protein_family
ROBO family
uniprot
proteins
pubmed
10102268
uniprot
proteins
pubmed
10997877
uniprot
proteins
pubmed
11404413
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
16829019
uniprot
proteins
pubmed
17357069
uniprot
proteins
pubmed
9458045
uniprot
proteins
sequence_length
1378
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 860..880; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins