Lamtor5
entrez
68576
canonical
uniprot
Q9D1L9
canonical
ensembl
ENSMUSG00000087260
resolver
ensp
ENSMUSP00000129012
resolver
ensp
ENSMUSP00000143494
resolver
enst
ENSMUST00000145735
resolver
enst
ENSMUST00000199317
resolver
genesymbol
Lamtor5
resolver
genesymbol_syn
Hbxip
resolver
genesymbol_syn
Xip
resolver
uniprot
G3UW70
resolver
uniprot
Q3UJV9
resolver
uniprot_entry
G3UW70_MOUSE
resolver
uniprot_entry
LTOR5_MOUSE
resolver
uniprot_sec
Q3UJV9
resolver
amino_acid_sequence
MEATLEQHLEDTMKNPSIVGVLCTDSQGLNLGCRGTLSDEHAGVISVLAQQAARLTSDPTDIPVVCLESDNGNIMIQKHDGITVAVHKMAS
uniprot
proteins
function
FUNCTION: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. When complexed to BIRC5, interferes with apoptosome assembly, preventing recruitment of pro-caspase-9 to oligomerized APAF1, thereby selectively suppressing apoptosis initiated via the mitochondrial/cytochrome c pathway. {ECO:0000250|UniProtKB:O43504}.
uniprot
proteins
mass_dalton
9642
uniprot
proteins
protein_family
LAMTOR5 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
91
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:O43504}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:O43504}.
uniprot
proteins