GINS2
entrez
51659
canonical
uniprot
Q9Y248
canonical
ensembl
ENSG00000131153
resolver
ensp
ENSP00000253462
resolver
enst
ENST00000253462
resolver
genesymbol
GINS2
resolver
genesymbol_syn
PSF2
resolver
hgnc
HGNC:24575
resolver
uniprot
D3DUM5
resolver
uniprot
Q6IAG9
resolver
uniprot_entry
PSF2_HUMAN
resolver
uniprot_sec
D3DUM5
resolver
uniprot_sec
Q6IAG9
resolver
amino_acid_sequence
MDAAEVEFLAEKELVTIIPNFSLDKIYLIGGDLGPFNPGLPVEVPLWLAINLKQRQKCRLLPPEWMDVEKLEKMRDHERKEETFTPMPSPYYMELTKLLLNHASDNIPKADEIRTLVKDMWDTRIAKLRVSADSFVRQQEAHAKLDNLTLMEINTSGTFLTQALNHMYKLRTNLQPLESTQSQDF
uniprot
proteins
function
FUNCTION: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks (PubMed:17417653). GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). {ECO:0000269|PubMed:17417653, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232}.
uniprot
proteins
mass_dalton
21428
uniprot
proteins
protein_family
GINS2/PSF2 family
uniprot
proteins
pubmed
10810093
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17417653
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
17545466
uniprot
proteins
pubmed
17557111
uniprot
proteins
pubmed
17652513
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
32453425
uniprot
proteins
pubmed
34694004
uniprot
proteins
pubmed
34700328
uniprot
proteins
pubmed
35585232
uniprot
proteins
sequence_length
185
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:35585232}. Chromosome {ECO:0000305|PubMed:35585232}. Note=Associates with chromatin. {ECO:0000305|PubMed:35585232}.
uniprot
proteins