A4galt
entrez
239559
canonical
uniprot
Q67BJ4
canonical
ensembl
ENSMUSG00000047878
resolver
ensp
ENSMUSP00000057999
resolver
ensp
ENSMUSP00000129719
resolver
ensp
ENSMUSP00000173802
resolver
ensp
ENSMUSP00000173803
resolver
ensp
ENSMUSP00000173804
resolver
enst
ENSMUST00000049530
resolver
enst
ENSMUST00000164614
resolver
genesymbol
A4galt
resolver
uniprot
Q0R0H6
resolver
uniprot
Q3TRS1
resolver
uniprot
Q3UF00
resolver
uniprot_entry
A4GAT_MOUSE
resolver
uniprot_entry
Q0R0H6_MOUSE
resolver
uniprot_entry
Q3TRS1_MOUSE
resolver
uniprot_entry
Q3UF00_MOUSE
resolver
amino_acid_sequence
MGISCSHLEETMSKPPDCLLRMLRGTPRQRVFTFFIISFKFMFLISILIYWHTVGAPKDQREYSLPVDFSCPQLAFPRVSAPGNIFFLETSDRTSPNFLFMCSVESAARAHPESQVVVLMKGLPRDTTAQPRNLGISLLSCFPNVWIRPLDLQELFEDTPLAAWYSEARHRWEPYQLPVLSDASRIALLWKFGGIYLDTDFIVLKNLLNLTNTLGIQSRYVLNGAFLAFERKHEFLALCLHDFVANYNGWIWGHQGPQLLTRVFKKWCSIQSLEKSHACRGVTALPPEAFYPIPWQNWKKYFEDISPEELTQLLNATYAVHVWNKKSQGTHLEATSKALLAQLHARYCPTTHRAMKMYL
uniprot
proteins
ec_number
2.4.1.228
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of galactose from UDP-alpha-D-galactose in an alpha1,4 linkage to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide(d18:1(4E)) to produce globotriaosylceramide/globoside Gb3Cer (d18:1(4E)), also known as CD77 (By similarity). Globoside Gb3Cer/CD77 is a root structure in biosynthesis pathway of neutral glycosphingolipids of the globo-series. Broadly expressed in cell membranes of immune cells and other tissues, Gb3Cer/CD77 antigen may participate in mechanisms that regulate cell-cell interactions and cell differentiation. In germinal center B cells, Gb3Cer/CD77 interacts with CD19 to drive centroblast-to-centrocyte transition, B cell receptor complex assembly and T follicular helper cell differentiation. In epithelium, Gb3Cer/CD77 regulates CDH1/E-cadherin-dependent cell-cell adhesion counteracting epithelial-to-mesenchymal transition (By similarity) (PubMed:38359115). Also able to transfer galactose to galactosylceramide/beta-D-Gal-(1<->1')-Cer (By similarity). {ECO:0000250|UniProtKB:Q9NPC4, ECO:0000269|PubMed:38359115}.
uniprot
proteins
mass_dalton
41366
uniprot
proteins
pathway_participation
PATHWAY: Glycolipid biosynthesis. {ECO:0000250|UniProtKB:Q9NPC4}.
uniprot
proteins
protein_family
Glycosyltransferase 32 family
uniprot
proteins
pubmed
38359115
uniprot
proteins
sequence_length
359
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 31..51; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins