Hmgcll1
entrez
208982
canonical
uniprot
Q8JZS7
canonical
ensembl
ENSMUSG00000007908
resolver
ensp
ENSMUSP00000008052
resolver
ensp
ENSMUSP00000261207
resolver
ensp
ENSMUSP00000261208
resolver
ensp
ENSMUSP00000261212
resolver
ensp
ENSMUSP00000261214
resolver
enst
ENSMUST00000008052
resolver
genesymbol
Hmgcll1
resolver
uniprot_entry
HMGC2_MOUSE
resolver
amino_acid_sequence
MGNLPSAAKHCLNYQQLLREHLWSGDSVAGALDAAQEASQLPGLPEYVKIVEVGPRDGLQNEKVIVPTDIKIELINQLSQTGLSVIEVTSFVSSRWVPQMADHAEVMRGIRQYPGVRYPVLTPNLQGFQHAVAAGATEIAVFGAASESFSKKNINCSIEESMGRFQEVISSARHMDIPVRGYVSCALGCPYEGSITPQKVTEVSKRLYGMGCYEISLGDTIGVGTPGSMKMMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSAVSGLGGCPYAKGASGNVATEDLIYMLNGMGLNTGVDLYKVMEAGEFICKAVNKTTNSKVAQASFNARLE
uniprot
proteins
ec_number
4.1.3.4
uniprot
proteins
function
FUNCTION: Non-mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues. {ECO:0000250}.
uniprot
proteins
mass_dalton
36650
uniprot
proteins
pathway_participation
PATHWAY: Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.
uniprot
proteins
protein_family
HMG-CoA lyase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
343
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
uniprot
proteins