DAD1
entrez
1603
canonical
uniprot
P61803
canonical
ensembl
ENSG00000129562
resolver
ensp
ENSP00000250498
resolver
ensp
ENSP00000530888
resolver
ensp
ENSP00000530889
resolver
ensp
ENSP00000608680
resolver
enst
ENST00000250498
resolver
enst
ENST00000860829
resolver
enst
ENST00000860830
resolver
enst
ENST00000938621
resolver
genesymbol
DAD1
resolver
hgnc
HGNC:2664
resolver
uniprot
D3DS25
resolver
uniprot
O08552
resolver
uniprot
O70364
resolver
uniprot
P46966
resolver
uniprot
P46968
resolver
uniprot
Q53G02
resolver
uniprot
Q6FGA3
resolver
uniprot
Q96GB7
resolver
uniprot_entry
DAD1_HUMAN
resolver
uniprot_entry
Q53G02_HUMAN
resolver
uniprot_sec
D3DS25
resolver
uniprot_sec
O08552
resolver
uniprot_sec
O70364
resolver
uniprot_sec
P46966
resolver
uniprot_sec
P46968
resolver
uniprot_sec
Q6FGA3
resolver
uniprot_sec
Q96GB7
resolver
amino_acid_sequence
MSASVVSVISRFLEEYLSSTPQRLKLLDAYLLYILLTGALQFGYCLLVGTFPFNSFLSGFISCVGSFILAVCLRIQINPQNKADFQGISPERAFADFLFASTILHLVVMNFVG
uniprot
proteins
function
FUNCTION: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:22467853, PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes. Loss of the DAD1 protein triggers apoptosis (PubMed:22467853). {ECO:0000250|UniProtKB:E2R4X3, ECO:0000269|PubMed:22467853, ECO:0000269|PubMed:31831667}.
uniprot
proteins
mass_dalton
12497
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:31831667}.
uniprot
proteins
protein_family
DAD/OST2 family
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22467853
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
25135935
uniprot
proteins
pubmed
25489052
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
31831667
uniprot
proteins
pubmed
36697828
uniprot
proteins
pubmed
38670073
uniprot
proteins
pubmed
8413235
uniprot
proteins
sequence_length
113
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 31..51; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 53..73; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 93..113; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins