RXFP2
entrez
122042
canonical
uniprot
Q8WXD0
canonical
ensembl
ENSG00000133105
resolver
ensp
ENSP00000298386
resolver
ensp
ENSP00000369670
resolver
genesymbol
RXFP2
resolver
genesymbol_syn
GPR106
resolver
genesymbol_syn
GREAT
resolver
genesymbol_syn
LGR8
resolver
hgnc
HGNC:17318
resolver
uniprot
B1ALE9
resolver
uniprot
Q3KU23
resolver
uniprot_entry
RXFP2_HUMAN
resolver
uniprot_sec
B1ALE9
resolver
uniprot_sec
Q3KU23
resolver
amino_acid_sequence
MIVFLVFKHLFSLRLITMFFLLHFIVLINVKDFALTQGSMITPSCQKGYFPCGNLTKCLPRAFHCDGKDDCGNGADEENCGDTSGWATIFGTVHGNANSVALTQECFLKQYPQCCDCKETELECVNGDLKSVPMISNNVTLLSLKKNKIHSLPDKVFIKYTKLKKIFLQHNCIRHISRKAFFGLCNLQILYLNHNCITTLRPGIFKDLHQLTWLILDDNPITRISQRLFTGLNSLFFLSMVNNYLEALPKQMCAQMPQLNWVDLEGNRIKYLTNSTFLSCDSLTVLFLPRNQIGFVPEKTFSSLKNLGELDLSSNTITELSPHLFKDLKLLQKLNLSSNPLMYLHKNQFESLKQLQSLDLERIEIPNINTRMFQPMKNLSHIYFKNFRYCSYAPHVRICMPLTDGISSFEDLLANNILRIFVWVIAFITCFGNLFVIGMRSFIKAENTTHAMSIKILCCADCLMGVYLFFVGIFDIKYRGQYQKYALLWMESVQCRLMGFLAMLSTEVSVLLLTYLTLEKFLVIVFPFSNIRPGKRQTSVILICIWMAGFLIAVIPFWNKDYFGNFYGKNGVCFPLYYDQTEDIGSKGYSLGIFLGVNLLAFLIIVFSYITMFCSIQKTALQTTEVRNCFGREVAVANRFFFIVFSDAICWIPVFVVKILSLFRVEIPDTMTSWIVIFFLPVNSALNPILYTLTTNFFKDKLKQLLHKHQRKSIFKIKKKSLSTSIVWIEDSSSLKLGVLNKITLGDSIMKPVS
uniprot
proteins
disease_involvement
DISEASE: Cryptorchidism (CRYPTO) [MIM:219050]: One of the most frequent congenital abnormalities in humans, involving 2-5% of male births. Cryptorchidism is associated with increased risk of infertility and testicular cancer. {ECO:0000269|PubMed:12217959}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Receptor for relaxin. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3).
uniprot
proteins
mass_dalton
86453
uniprot
proteins
mutagenesis
MUTAGEN 647; /note="D->Y: Leads to constitutive increase of basal cAMP."; /evidence="ECO:0000269|PubMed:11809971
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11809971
uniprot
proteins
pubmed
12217959
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
16051677
uniprot
proteins
sequence_length
754
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 417..437; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 456..476; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 496..518; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 538..558; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 593..613; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 640..660; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 671..691; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins