Dkc1
entrez
170944
canonical
uniprot
P40615
canonical
ensembl
ENSRNOG00055000727
resolver
ensembl
ENSRNOG00055024200
resolver
ensembl
ENSRNOG00060008746
resolver
ensembl
ENSRNOG00060008779
resolver
ensembl
ENSRNOG00065000181
resolver
ensembl
ENSRNOG00065014381
resolver
ensp
ENSRNOP00055001004
resolver
ensp
ENSRNOP00055033814
resolver
ensp
ENSRNOP00060011292
resolver
ensp
ENSRNOP00060011347
resolver
ensp
ENSRNOP00065000307
resolver
ensp
ENSRNOP00065018484
resolver
enst
ENSRNOT00055001251
resolver
enst
ENSRNOT00055041561
resolver
enst
ENSRNOT00060014638
resolver
enst
ENSRNOT00060014691
resolver
enst
ENSRNOT00065000312
resolver
enst
ENSRNOT00065023745
resolver
genesymbol
Dkc1
resolver
genesymbol_syn
Nap57
resolver
uniprot
Q499M9
resolver
uniprot_entry
DKC1_RAT
resolver
uniprot_sec
Q499M9
resolver
amino_acid_sequence
MADAEAAMTFPKKHKKKKERKPLPEADVAEIQHAEDFLIKPESKAAQLDTSQWPLLLKNFDRLNVRTTHYTPIPCGSNPLKREIGEYVRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGVVRLHNAIEGTAQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESRVVEYDPERRLGVFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVVGERDHMVTMHDVLDAQYLYDHHRDESYLRRVVFPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGLLRYEDGIEVNQEVVVITTKGEAVCVAIALMTTAVISTCDHGVVAKIKRVIMERDTYPRKWGLGPKASQKKQLIKQGLLDKHGRPTDGTPASWTRDYVDYSDSSKKATAAEATPGPGVTADAASIVKRKRDSDSDADEATPTTTPRVKKEKKKKKEKADGGEEAAEDGDGDATRKKKKKKARAAEELSG
uniprot
proteins
ec_number
5.4.99.-
uniprot
proteins
function
FUNCTION: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:12446766). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1 (By similarity). Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs (By similarity). Required for ribosome biogenesis and telomere maintenance (By similarity). Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity). {ECO:0000250|UniProtKB:O60832, ECO:0000269|PubMed:12446766}.
uniprot
proteins
mass_dalton
56615
uniprot
proteins
protein_family
Pseudouridine synthase TruB family
uniprot
proteins
pubmed
12446766
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7798307
uniprot
proteins
sequence_length
509
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:7798307}. Nucleus, Cajal body {ECO:0000269|PubMed:7798307}.
uniprot
proteins