Robo1
entrez
19876
canonical
uniprot
O89026
canonical
ensembl
ENSMUSG00000022883
resolver
ensp
ENSMUSP00000023600
resolver
ensp
ENSMUSP00000155958
resolver
ensp
ENSMUSP00000231415
resolver
enst
ENSMUST00000023600
resolver
genesymbol
Robo1
resolver
genesymbol_syn
Dutt1
resolver
uniprot
G5E843
resolver
uniprot
Q3UQ03
resolver
uniprot
Q3UXH3
resolver
uniprot_entry
G5E843_MOUSE
resolver
uniprot_entry
Q3UQ03_MOUSE
resolver
uniprot_entry
Q3UXH3_MOUSE
resolver
uniprot_entry
ROBO1_MOUSE
resolver
amino_acid_sequence
MIAEPAHFYLFGLICLCSGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYICVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTLILSCVATGSPAPTILWRKDGVLVSTQDSRIKQLESGVLQIRYAKLGDTGRYTCTASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSKNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTAAENVKTETFAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVPPTSQGVDHKQVQRELGNVVLHLHNPTILSSSSVEVHWTVDQQSQYIQGYKILYRPSGASHGESEWLVFEVRTPTKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPRSVTVSKNDGNGTAILVTWQPPPEDTQNGMVQEYKVWCLGNETKYHINKTVDGSTFSVVIPSLVPGIRYSVEVAASTGAGPGVKSEPQFIQLDSHGNPVSPEDQVSLAQQISDVVRQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGGEAVSSGGRPGLLNISEPATQPWLADTWPNTGNNHNDCSINCCTAGNGNSDSNLTTYSRPADCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQANLSNNMNNGAGDSSEKHWKPPGQQKPEVAPIQYNIMEQNKLNKDYRANDTIPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKAPKQGGMNWADLLPPPPAHPPPHSNSEEYNMSVDESYDQEMPCPVPPAPMYLQQDELQEEEDERGPTPPVRGAASSPAAVSYSHQSTATLTPSPQEELQPMLQDCPEDLGHMPHPPDRRRQPVSPPPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAVVIQKARPAKKQKHQPGHLRREAYADDLPPPPVPPPAIKSPTVQSKAQLEVRPVMVPKLASIEARTDRSSDRKGGSYKGREALDGRQVTDLRTNPSDPREAQEQPNDGKGRGTRQPKRDLPPAKTHLGQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQREQANVGRRNMAEMQVLGGFERGDENNEELEETES
uniprot
proteins
function
FUNCTION: Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10433822, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (By similarity). May be required for lung development (PubMed:11734623). {ECO:0000250|UniProtKB:Q9Y6N7, ECO:0000269|PubMed:10433822, ECO:0000269|PubMed:11734623, ECO:0000269|PubMed:15091338, ECO:0000269|PubMed:24560577}.
uniprot
proteins
mass_dalton
176407
uniprot
proteins
mutagenesis
MUTAGEN 270; /note="I->T: Loss of expression in the kidney of homozygous mice. Mutant mice have severe urogenital defects, congenital heart defects and craniofacial abnormalities."; /evidence="ECO:0000269|PubMed:35227688
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. May be deubiquitinated by USP33. {ECO:0000269|PubMed:19684588}.
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
protein_family
ROBO family
uniprot
proteins
pubmed
10433822
uniprot
proteins
pubmed
11734623
uniprot
proteins
pubmed
12123796
uniprot
proteins
pubmed
15091338
uniprot
proteins
pubmed
19684588
uniprot
proteins
pubmed
19706539
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24560577
uniprot
proteins
pubmed
35227688
uniprot
proteins
pubmed
9608531
uniprot
proteins
sequence_length
1612
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24560577}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000269|PubMed:24560577}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:O55005}; Single-pass membrane protein {ECO:0000250|UniProtKB:O55005}. Note=Detected at growth cones in thalamus neurons (PubMed:24560577). PRRG4 prevents cell surface location and both colocalize in the Endoplasmic reticulum/Golgi adjacent to the cell nucleus (By similarity). {ECO:0000250|UniProtKB:O55005, ECO:0000269|PubMed:24560577}.
uniprot
proteins
transmembrane_region
TRANSMEM 859..879; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins