Pdzrn3
entrez
55983
canonical
uniprot
Q69ZS0
canonical
ensembl
ENSMUSG00000035357
resolver
ensp
ENSMUSP00000075376
resolver
genesymbol
Pdzrn3
resolver
genesymbol_syn
Kiaa1095
resolver
genesymbol_syn
Semcap3
resolver
uniprot
Q3UPS8
resolver
uniprot
Q91Z03
resolver
uniprot
Q9QY54
resolver
uniprot
Q9QY55
resolver
uniprot_entry
PZRN3_MOUSE
resolver
uniprot_entry
Q3UPS8_MOUSE
resolver
uniprot_sec
Q91Z03
resolver
uniprot_sec
Q9QY54
resolver
uniprot_sec
Q9QY55
resolver
amino_acid_sequence
MGFELDRFDGDVDPDLKCALCHKVLEDPLTTPCGHVFCAGCVLPWVVQEGSCPARCRGRLSAKELNHVLPLKRLILKLDIKCAHAARGCGRVVKLQDLPEHLERCDFAPARCRHAGCGQLLLRRDVEAHMRDACDARPVGRCQEGCGLPLTHGEQRAGGHCCARALRAHNGALQARLGALHKALKKEALRAGKREKSLVAQLAAAQLELQMTALRYQKKFTEYSARLDSLSRCVAAPPGGKGEETKSLTLVLHRDSGSLGFNIIGGRPCVDNQDGSSSEGIFVSKIVDSGPAAKEGGLQIHDRIIEVNGKDLSRATHDQAVEAFKTAKEPIVVQVLRRTPRTKMFTPASESQLVDTGTQTDITFEHIMALTKMSSPSPPVLDPYLLPEEHPASHDYYDPNDYMGDIHQDMDREELELEEVGLYRMNSQDKLGLTVCYRTDDEDDIGIYISEIDPNSIAAKDGRIREGDRIIQINGIEVQNREEAVALLTSEENKNFSLLIARPELQLDEGWMDDDRNDFLDDLHMDMLEEQHHQAMQFTASVLQQKKHEEDGGTTDTATILSNQHEKDSGVGRTDESTRNDESSEQENNGEDATASANPLAGQRKLTCSQDTLGSGDLPFSNESFISADCTDVDYLGIPEDECERFRELLELKCQVQSASPYSLYYPSSPLDAAGKSDPESVDKELELLNEELRSIELECLSIVRAHKMQQLKEQYRESWMLHHSGFRNYNTSVDVRRHELSDITELPEKSDKDSSSAYNTGESCRSTPLTLEISPDNSLRRVAEGSSEGATANIEAYRPSPKNLLAITEDPEVSTPSYNPSAKELDPSQALEIKERRGSDGSRSPTASPKLGNAYLPSYHHSPYKHAHIPAHAQHYQSYMHLIQQKSAVEYAQSQMSLVSMCKDLNSSNSVEPRMEWKVKIRSDGTRYITKRPVRDRLLRERALKIREERSGLTTDDDAMSEMKMGRYWSKEERKQHLVKAKEQRRRREFMMQSRLDCLKEQQASDDRKEMNILELSHKKMMKKRNKKIFDNWMTIQELLTHGTKSPDGTRVYNSFLSVTTV
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation. {ECO:0000269|PubMed:17118964, ECO:0000269|PubMed:17576800}.
uniprot
proteins
mass_dalton
119401
uniprot
proteins
mutagenesis
MUTAGEN 18; /note="C->A: Loss of E3 ligase activity."; /evidence="ECO:0000269|PubMed:17576800"; MUTAGEN 38; /note="C->A: Loss of E3 ligase activity."; /evidence="ECO:0000269|PubMed:17576800
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:17576800}.
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated. {ECO:0000269|PubMed:17576800}.
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17118964
uniprot
proteins
pubmed
17576800
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1063
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Synapse {ECO:0000269|PubMed:17576800}. Cytoplasm {ECO:0000250|UniProtKB:E7FDW2}. Note=Localizes to the postsynaptic region of neuromuscular junctions. {ECO:0000269|PubMed:17576800}.
uniprot
proteins