Esyt1
entrez
29579
canonical
uniprot
Q9Z1X1
canonical
ensembl
ENSRNOG00000060753
resolver
ensp
ENSRNOP00000070299
resolver
enst
ENSRNOT00000082107
resolver
genesymbol
Esyt1
resolver
genesymbol_syn
Fam62a
resolver
genesymbol_syn
Mbc2
resolver
uniprot
A0A0G2JXJ7
resolver
uniprot
Q3T1L3
resolver
uniprot_entry
A0A0G2JXJ7_RAT
resolver
uniprot_entry
ESYT1_RAT
resolver
uniprot_sec
Q3T1L3
resolver
amino_acid_sequence
MERSPEEGAGPEPSGQSPATDSTRERDGGSGVPPAGPGAASEALAVLTSFGRRLLVLVPVYLAGAAGLSVGFVLFGLALYLGWRRVRDGKERSLRAARQLLDDEERITAETLYMSHRELPAWVSFPDVEKAEWLNKIVVQVWPFLGQYMEKLLAETVAPAVRGANPHLQTFTFTRVELGEKPVRIIGVKVHPSQRKDQILLDLNVSYVGDLQIDVEVKKYFCKAGVKGMQLHGVLRVILEPLIGDLPIVGAVSMFFIKRPTLDINWTGMTNLLDIPGLSSLSDTMIMDSIAAFLVLPNRLLVPLVPDLQDVAQLRSPLPRGIIRIHLLAARGLSSKDKYVKGLIEGKSDPYALVRVGTQTFCSRVIDEELNPHWGETYEVIVHEVPGQEIEVEVFDKDPDKDDFLGRMKLDVGKVLQAGVLDNWYPLQGGQGQVHLRLEWLSLLPDAEKLDQVLQWNRGITSRPEPPSAAILVVYLDRAQDLPLKKGNKEPNPMVQLSVQDVTQESKATYSTNCPVWEEAFRFFLQDPRSQELDVQVKDDSRALTLGALTLPLARLLTASELTLDQWFQLSSSGPNSRLYMKLVMRILYLDSSEMRLPTEPGAQDWDSESPETGSSVDAPPRPYHTTPNSHFGTENVLRIHVLEAQDLIAKDRFLGGLVKGKSDPYVKLKVAGRSLRTHVVREDLNPRWNEVFEVIVTSIPGQELDIEVFDKDLDKDDFLGRYKVGLTTVLNSGFLDEWLTLEDVPSGRLHLRLERLSPRPTAAELEEVLQVNSLIQTQKSSELAAALLSVYLERSEDLPLRKGTKPPSPYAILTVGETSHKTKTVSQTSAPIWEESASFLIRKPHAESLELQVRGEGTGTLGSISLPLSELLQEEQLCLDRWFALSGQGQVLMRVQLGILVSQHSGVEAHSHSSSSLNEEPEVLGDPTHTASPVLEVRHRLTHGDSPSEALIGPLGQVKLTVWYHSDEQKLISIIHSCRALRQNGRDLPDPYVSVLLLPDKNRGTKRKTSQKKRTLNPEFNERFEWDLPLDGTLRRKLDVSVKSNSSFMSRERELLGKVQLDLAEIDLSQGAAQWYDLIDDRDKGGS
uniprot
proteins
function
FUNCTION: Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Acts as an inhibitor of ADGRD1 G protein-coupled receptor activity in absence of cytosolic calcium (By similarity). Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). {ECO:0000250|UniProtKB:A0FGR8, ECO:0000250|UniProtKB:Q9BSJ8}.
uniprot
proteins
mass_dalton
121159
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser residues in insulin-treated adipocytes (in vitro); this promotes interaction with SLC2A4. {ECO:0000250}.
uniprot
proteins
protein_family
Extended synaptotagmin family
uniprot
proteins
pubmed
10350628
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
1088
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9BSJ8}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9BSJ8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9BSJ8}. Note=Localizes primarily to the endoplasmic reticulum. Recruited to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. {ECO:0000250|UniProtKB:Q9BSJ8}.
uniprot
proteins
transmembrane_region
TRANSMEM 31..51; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 55..75; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins