Apbb1ip
entrez
54519
canonical
uniprot
Q8R5A3
canonical
ensembl
ENSMUSG00000026786
resolver
ensp
ENSMUSP00000014290
resolver
enst
ENSMUST00000014290
resolver
genesymbol
Apbb1ip
resolver
genesymbol_syn
Prel1
resolver
uniprot
B1AYC9
resolver
uniprot
O35329
resolver
uniprot
Q8BRU0
resolver
uniprot
Q99KV8
resolver
uniprot_entry
AB1IP_MOUSE
resolver
uniprot_entry
B1AYC9_MOUSE
resolver
uniprot_sec
O35329
resolver
uniprot_sec
Q8BRU0
resolver
uniprot_sec
Q99KV8
resolver
amino_acid_sequence
MGESNEDIDQMFSTLLGEMDLLTQSLGVDTLPPPDPNPPREEFNYTVGFKDLNESLNALEDQDLDALMADLVADISEAEQRTIQAQKESSQNQDRFALLRASDGQGTASGGYGASAAAIDVSHHEEALPPPPVEPMLDLLPPPPPPPPPELLSKEEEEAKAKADKIKLALEKLKEAKVKKLVVKVHMDDSSTKSLMVDERQLARDVLDNLFEKTHCDCNVDWCLYEIYPELQIERVFEDHENVVEVLSDWTRDTENKVLFLEKEERYAVFKNPQNFYLDNKGKKENKETNEKMNAKNKEYLLEESFCGTSIIVPELEGALYLKEDGKKSWKRRYFLLRASGIYYVPKGKTKTSRDLACFIQFENVNIYYGIQCKMKYKAPTDHCFVLKHPQIQKESQYIKYLCCDDARTLSQWVMGIRIAKYGKTLYDNYQRAVARAGLASRWTNLGTVGTPMPAQPSTVSSGLKTGTSQPNGQMPQAIPSAGPPLQEAQTQIETTKDEKQGLGNHSPGATRENHRPKSSLPPPPPPVRRSSDTCGSPALPSKVKGPGTCTFPHPPENFLPPPPPPPPEEDNSGLLPPPPPPPYLEEPPDFVPPPPPPAAVEDSALPPPPPPPPCLSQEITKSSPLPPKKPLVPPKRQENQGLPGAPGNSEQDFMSDLMKALQKKRGNIP
uniprot
proteins
function
FUNCTION: Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling. Suppresses insulin-induced promoter activities through AP1 and SRE. Mediates Rap1-induced adhesion (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
74319
uniprot
proteins
protein_family
MRL family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15642358
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9407065
uniprot
proteins
sequence_length
670
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15642358}; Peripheral membrane protein {ECO:0000269|PubMed:15642358}. Cell projection, lamellipodium {ECO:0000269|PubMed:15642358}. Cell junction, focal adhesion {ECO:0000269|PubMed:15642358}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15642358}. Note=Colocalizes with ENA/VASP proteins at lamellipodia tips and focal adhesions, and F-actin at the leading edge. At the membrane surface, associates, via the PH domain, preferentially with the inositol phosphates, PtdIns(5)P and PtdIns(3)P. This binding appears to be necessary for the efficient interaction of the RA domain to Ras-GTPases.
uniprot
proteins