Scn4b
entrez
315611
canonical
uniprot
Q7M730
canonical
ensembl
ENSRNOG00000026679
resolver
ensembl
ENSRNOG00055019908
resolver
ensembl
ENSRNOG00060019214
resolver
ensembl
ENSRNOG00065024473
resolver
ensp
ENSRNOP00000033284
resolver
ensp
ENSRNOP00055027614
resolver
ensp
ENSRNOP00060027202
resolver
ensp
ENSRNOP00065034310
resolver
enst
ENSRNOT00000030152
resolver
enst
ENSRNOT00055033998
resolver
enst
ENSRNOT00060033235
resolver
enst
ENSRNOT00065041975
resolver
genesymbol
Scn4b
resolver
uniprot
Q80Z84
resolver
uniprot_entry
SCN4B_RAT
resolver
uniprot_sec
Q80Z84
resolver
amino_acid_sequence
MSRAGNRGNTQARWLGIGLLGLFLLPMYLSLEVSVGKATTIYAINGSAILLPCTFSSCYGFENLYFRWSYNNSETSRILIDGIVKNDKSDPKVRVKDDDRITLEGSTKEKMNNISILLSDLEFSDTGRYTCFVRNPKEKDLNNSATIFLQVVDKLEEVDNTVTLIILAVVGGVIGLLVCILLLKKLITFILKKTREKKKECLVSSSGNDNTENGLPGSKAEEKPPTKV
uniprot
proteins
function
FUNCTION: Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels (PubMed:12930796). Modulates the activity of SCN1A/Nav1.1 (By similarity). Modulates the activity of SCN2A/Nav1.2 (PubMed:12930796). {ECO:0000250|UniProtKB:Q8IWT1, ECO:0000269|PubMed:12930796}.
uniprot
proteins
mass_dalton
25247
uniprot
proteins
post_translational_modification
PTM: Contains an interchain disulfide bond with SCN2A. {ECO:0000250|UniProtKB:Q8IWT1}.
uniprot
proteins
protein_family
Sodium channel auxiliary subunit SCN4B (TC 8.A.17) family
uniprot
proteins
pubmed
12930796
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
24090084
uniprot
proteins
pubmed
26894959
uniprot
proteins
sequence_length
228
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12930796}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q8IWT1}.
uniprot
proteins
transmembrane_region
TRANSMEM 162..182; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins