Nptn
entrez
56064
canonical
uniprot
P97546
canonical
ensembl
ENSRNOG00000009029
resolver
ensp
ENSRNOP00000012091
resolver
ensp
ENSRNOP00000012295
resolver
ensp
ENSRNOP00000105040
resolver
enst
ENSRNOT00000012091
resolver
genesymbol
Nptn
resolver
genesymbol_syn
Sdfr1
resolver
genesymbol_syn
Sdr1
resolver
uniprot
A0A8L2Q5B1
resolver
uniprot
P97547
resolver
uniprot
Q6IRE8
resolver
uniprot_entry
A0A8L2Q5B1_RAT
resolver
uniprot_entry
NPTN_RAT
resolver
uniprot_sec
P97547
resolver
uniprot_sec
Q6IRE8
resolver
amino_acid_sequence
MSGSSLPGALALSLLLVSGSLLPGPGAAQNAGFVKSPMSETKLTGDAFELYCDVVGSPTPEIQWWYAEVNRAESFRQLWDGARKRRVTVNTAYGSNGVSVLRITRLTLEDSGTYECRASNDPKRNDLRQNPSITWIRAQATISVLQKPRIVTSEEVIIRDSLLPVTLQCNLTSSSHTLMYSYWTKNGVELTATRKNASNMEYRINKPRAEDSGEYHCVYHFVSAPKANATIEVKAAPDITGHKRSENKNEGQDAMMYCKSVGYPHPEWMWRKKENGVFEEISNSSGRFFIINKENYTELNIVNLQITEDPGEYECNATNSIGSASVSTVLRVRSHLAPLWPFLGILAEIIILVVIIVVYEKRKRPDEVPDAGPMKTNSTNNHKDKNLRQRNTN
uniprot
proteins
function
FUNCTION: Accessory subunit of plasma membrane calcium-transporting ATPase ATP2B2/PMCA2 that stabilizes the transporter at the cell surface (By similarity). Also acts as a chaperone for ATP2B1; stabilizes ATP2B1 and increases its ATPase activity (By similarity). Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK (PubMed:10759566, PubMed:16925595). May also regulate neurite outgrowth by activating the FGFR1 signaling pathway (PubMed:10759566, PubMed:16925595). May play a role in synaptic plasticity (PubMed:10759566, PubMed:16925595). Promotes localization of XKR8 at the cell membrane (By similarity). {ECO:0000250|UniProtKB:P97300, ECO:0000250|UniProtKB:Q9Y639, ECO:0000269|PubMed:10759566, ECO:0000269|PubMed:16925595}.
uniprot
proteins
mass_dalton
43932
uniprot
proteins
post_translational_modification
PTM: Isoform 1 and isoform 2 are N-glycosylated. {ECO:0000269|PubMed:19952283, ECO:0000269|PubMed:8995369}.
uniprot
proteins
pubmed
10759566
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16925595
uniprot
proteins
pubmed
19952283
uniprot
proteins
pubmed
24090084
uniprot
proteins
pubmed
8995369
uniprot
proteins
sequence_length
393
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P97300}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P97300}.; SUBCELLULAR LOCATION: [Isoform 2]: Postsynaptic density {ECO:0000269|PubMed:10759566}.
uniprot
proteins
transmembrane_region
TRANSMEM 339..359; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P97300
uniprot
proteins