Dkk3
entrez
50781
canonical
uniprot
Q9QUN9
canonical
ensembl
ENSMUSG00000030772
resolver
ensp
ENSMUSP00000033036
resolver
ensp
ENSMUSP00000196216
resolver
ensp
ENSMUSP00000196217
resolver
enst
ENSMUST00000033036
resolver
genesymbol
Dkk3
resolver
uniprot_entry
DKK3_MOUSE
resolver
amino_acid_sequence
MQRLGGILLCTLLAAAVPTAPAPSPTVTWTPAEPGPALNYPQEEATLNEMFREVEELMEDTQHKLRSAVEEMEAEEAAAKTSSEVNLASLPPNYHNETSTETRVGNNTVHVHQEVHKITNNQSGQVVFSETVITSVGDEEGKRSHECIIDEDCGPTRYCQFSSFKYTCQPCRDQQMLCTRDSECCGDQLCAWGHCTQKATKGGNGTICDNQRDCQPGLCCAFQRGLLFPVCTPLPVEGELCHDPTSQLLDLITWELEPEGALDRCPCASGLLCQPHSHSLVYMCKPAFVGSHDHSEESQLPREAPDEYEDVGFIGEVRQELEDLERSLAQEMAFEGPAPVESLGGEEEI
uniprot
proteins
function
FUNCTION: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
38388
uniprot
proteins
protein_family
Dickkopf family
uniprot
proteins
pubmed
10495270
uniprot
proteins
pubmed
10570958
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17143291
uniprot
proteins
pubmed
27550540
uniprot
proteins
sequence_length
349
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins