Kansl2
entrez
69612
canonical
uniprot
Q8BQR4
canonical
ensembl
ENSMUSG00000022992
resolver
ensp
ENSMUSP00000112101
resolver
ensp
ENSMUSP00000155089
resolver
ensp
ENSMUSP00000222354
resolver
ensp
ENSMUSP00000222355
resolver
ensp
ENSMUSP00000222356
resolver
ensp
ENSMUSP00000222367
resolver
genesymbol
Kansl2
resolver
genesymbol_syn
Nsl2
resolver
uniprot
Q3TJH8
resolver
uniprot
Q569W7
resolver
uniprot
Q5XJH6
resolver
uniprot
Q8C8F3
resolver
uniprot
Q8C8I6
resolver
uniprot
Q8CEY3
resolver
uniprot
Q99LE5
resolver
uniprot_entry
KANL2_MOUSE
resolver
uniprot_sec
Q3TJH8
resolver
uniprot_sec
Q569W7
resolver
uniprot_sec
Q5XJH6
resolver
uniprot_sec
Q8C8F3
resolver
uniprot_sec
Q8C8I6
resolver
uniprot_sec
Q8CEY3
resolver
uniprot_sec
Q99LE5
resolver
amino_acid_sequence
MNRIRIHVLPTNRGRITPVPRSQEPLSCSFTHRPCSQPRLEGQEFCIKHILEDKNAPFKQCSYVSTKNGKRCPSAAPKPEKKDGVSFCAEHARRNALALHAQMKKSNPGPMGETLLCQLSSYAKTELGSQTPESSRSEASRILDEDSWSDGDQEPITVDQTWRGDPDSEADSIDSDQEDPLKHAGVYTAEEVALIMREKLIRLQSLYIDQFKRLQHLLKEKKRRYLHNRKVEHEALGSSLLTGPEGLLAKERENLKRLKCLRRYRQRYGVEALLHRQLKERRMLATDGAAQQAHTTRSSQRCLAFVDDVRCSNQSLPMTRHCLTHICQDTNQVLFKCCQGSEEVPCNKPVPVSLSEDPCCPLHFQLPPQMYKPEQVLSVPDDLEAGPMDLYLSAAELQPTESLPLEFSDDLDVVGDGMPCPPSPLLFDPSLTLEDHSVTESAGDAGQMQAAGDGCRSQGARSVEKAAFPQRGLATANGKPEPTSIS
uniprot
proteins
function
FUNCTION: Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation (By similarity). Required for NSL complex stability and for transcription of intraciliary transport genes in both ciliated and non-ciliated cells by regulating histone H4 acetylation at 'Lys-5'- and 'Lys-12' (H4K5ac and H4K12ac) (PubMed:37624894). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells (PubMed:37624894). Required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA (PubMed:31576060). {ECO:0000250|UniProtKB:Q9H9L4, ECO:0000269|PubMed:31576060, ECO:0000269|PubMed:37624894}.
uniprot
proteins
mass_dalton
54173
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24842875
uniprot
proteins
pubmed
31576060
uniprot
proteins
pubmed
37624894
uniprot
proteins
pubmed
37813994
uniprot
proteins
sequence_length
486
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H9L4}. Mitochondrion {ECO:0000269|PubMed:37813994}.
uniprot
proteins