DNAJA3
entrez
9093
canonical
uniprot
Q96EY1
canonical
ensembl
ENSG00000103423
resolver
ensembl
ENSG00000276726
resolver
ensp
ENSP00000262375
resolver
ensp
ENSP00000347445
resolver
ensp
ENSP00000393970
resolver
ensp
ENSP00000555932
resolver
genesymbol
DNAJA3
resolver
genesymbol_syn
HCA57
resolver
genesymbol_syn
TID1
resolver
hgnc
HGNC:11808
resolver
uniprot
B2RAJ5
resolver
uniprot
B3KM81
resolver
uniprot
B4DI33
resolver
uniprot
E7ES32
resolver
uniprot
O75472
resolver
uniprot
Q53G26
resolver
uniprot
Q59E88
resolver
uniprot
Q8WUJ6
resolver
uniprot
Q8WXJ3
resolver
uniprot
Q96D76
resolver
uniprot
Q96IV1
resolver
uniprot
Q9NYH8
resolver
uniprot_entry
B3KM81_HUMAN
resolver
uniprot_entry
DNJA3_HUMAN
resolver
uniprot_entry
Q53G26_HUMAN
resolver
uniprot_entry
Q59E88_HUMAN
resolver
uniprot_sec
B2RAJ5
resolver
uniprot_sec
B4DI33
resolver
uniprot_sec
E7ES32
resolver
uniprot_sec
O75472
resolver
uniprot_sec
Q8WUJ6
resolver
uniprot_sec
Q8WXJ3
resolver
uniprot_sec
Q96D76
resolver
uniprot_sec
Q96IV1
resolver
uniprot_sec
Q9NYH8
resolver
amino_acid_sequence
MAARCSTRWLLVVVGTPRLPAISGRGARPPREGVVGAWLSRKLSVPAFASSLTSCGPRALLTLRPGVSLTGTKHNPFICTASFHTSAPLAKEDYYQILGVPRNASQKEIKKAYYQLAKKYHPDTNKDDPKAKEKFSQLAEAYEVLSDEVKRKQYDAYGSAGFDPGASGSQHSYWKGGPTVDPEELFRKIFGEFSSSSFGDFQTVFDQPQEYFMELTFNQAAKGVNKEFTVNIMDTCERCNGKGNEPGTKVQHCHYCGGSGMETINTGPFVMRSTCRRCGGRGSIIISPCVVCRGAGQAKQKKRVMIPVPAGVEDGQTVRMPVGKREIFITFRVQKSPVFRRDGADIHSDLFISIAQALLGGTARAQGLYETINVTIPPGTQTDQKIRMGGKGIPRINSYGYGDHYIHIKIRVPKRLTSRQQSLILSYAEDETDVEGTVNGVTLTSSGGSTMDSSAGSKARREAGEDEEGFLSKLKKMFTS
uniprot
proteins
function
FUNCTION: Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway.
uniprot
proteins
mass_dalton
52489
uniprot
proteins
mutagenesis
MUTAGEN 121; /note="H->Q: Loss of modulation of apoptosis."; /evidence="ECO:0000269|PubMed:10411904
uniprot
proteins
post_translational_modification
PTM: Tyrosine phosphorylated. {ECO:0000250}.
uniprot
proteins
pubmed
10411904
uniprot
proteins
pubmed
11679576
uniprot
proteins
pubmed
12097419
uniprot
proteins
pubmed
12783860
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23455924
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
9683573
uniprot
proteins
sequence_length
480
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix. Cytoplasm, cytosol {ECO:0000250}. Postsynaptic cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Recruited to the postsynaptic cell membrane of the neuromuscular junction through interaction with MUSK. {ECO:0000250}.
uniprot
proteins