Srp54
entrez
24067
canonical
uniprot
P14576
canonical
ensembl
ENSMUSG00000073079
resolver
ensembl
ENSMUSG00000112449
resolver
ensp
ENSMUSP00000021407
resolver
ensp
ENSMUSP00000152764
resolver
ensp
ENSMUSP00000216457
resolver
genesymbol
Srp54
resolver
uniprot
Q3UWX8
resolver
uniprot
Q9CWH7
resolver
uniprot
Q9D008
resolver
uniprot_entry
SRP54_MOUSE
resolver
uniprot_sec
Q3UWX8
resolver
uniprot_sec
Q9CWH7
resolver
uniprot_sec
Q9D008
resolver
amino_acid_sequence
MVLADLGRKITSALRSLSNATIINEEVLNAMLKEVCTALLEADVNIKLVKQLRENVKSAIDLEEMASGLNKRKMIQHAVFKELVKLVDPGVKAWTPTKGKQNVIMFVGLQGSGKTTTCSKLAYYYQRKGWKTCLICADTFRAGAFDQLKQNATKARIPFYGSYTEMDPVIIASEGVEKFKNENFEIIIVDTSGRHKQEDSLFEEMLQVSNAIQPDNIVYVMDASIGQACEAQAKAFKDKVDVASVIVTKLDGHAKGGGALSAVAATKSPIIFIGTGEHIDDFEPFKTQPFISKLLGMGDIEGLIDKVNELKLDDNEALIEKLKHGQFTLRDMYEQFQNIMKMGPFSQILGMIPGFGTDFMSKGNEQESMARLKKLMTIMDSMNDQELDSTDGAKVFSKQPGRIQRVARGSGVSTRDVQELLTQYTKFAQMVKKMGGIKGLFKGGDMSKNVSQSQMAKLNQQMAKMMDPRVLHHMGGMAGLQSMMRQFQQGAAGNMKGMMGFNNM
uniprot
proteins
ec_number
3.6.5.4
uniprot
proteins
function
FUNCTION: Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (By similarity). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane (By similarity). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes (By similarity). Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA (By similarity). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA (By similarity). SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER (By similarity). Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA (By similarity). Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development (By similarity). {ECO:0000250|UniProtKB:P61010, ECO:0000250|UniProtKB:P61011}.
uniprot
proteins
mass_dalton
55721
uniprot
proteins
protein_family
GTP-binding SRP family
uniprot
proteins
protein_family
SRP54 subfamily
uniprot
proteins
pubmed
14985753
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1702385
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2502718
uniprot
proteins
sequence_length
504
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:P61011}. Cytoplasm {ECO:0000250|UniProtKB:P61011}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P61011}.
uniprot
proteins