PAFAH1B3
entrez
5050
canonical
uniprot
Q15102
canonical
ensembl
ENSG00000079462
resolver
ensp
ENSP00000262890
resolver
ensp
ENSP00000444935
resolver
ensp
ENSP00000547913
resolver
ensp
ENSP00000547914
resolver
enst
ENST00000262890
resolver
enst
ENST00000538771
resolver
enst
ENST00000877854
resolver
genesymbol
PAFAH1B3
resolver
genesymbol_syn
PAFAHG
resolver
hgnc
HGNC:8576
resolver
uniprot
A0A024R0L6
resolver
uniprot
Q53X88
resolver
uniprot_entry
A0A024R0L6_HUMAN
resolver
uniprot_entry
PA1B3_HUMAN
resolver
uniprot_sec
Q53X88
resolver
activity_regulation
ACTIVITY REGULATION: Beta subunit (PAFAH1B1) inhibits the acetylhydrolase activity of the alpha1/alpha1 catalytic homodimer. {ECO:0000250|UniProtKB:Q29460}.
uniprot
proteins
amino_acid_sequence
MSGEENPASKPTPVQDVQGDGRWMSLHHRFVADSKDKEPEVVFIGDSLVQLMHQCEIWRELFSPLHALNFGIGGDGTQHVLWRLENGELEHIRPKIVVVWVGTNNHGHTAEQVTGGIKAIVQLVNERQPQARVVVLGLLPRGQHPNPLREKNRQVNELVRAALAGHPRAHFLDADPGFVHSDGTISHHDMYDYLHLSRLGYTPVCRALHSLLLRLLAQDQGQGAPLLEPAP
uniprot
proteins
ec_number
3.1.1.47
uniprot
proteins
function
FUNCTION: Alpha1 catalytic subunit of the cytosolic type I platelet-activating factor (PAF) acetylhydrolase (PAF-AH (I)) heterotetrameric enzyme that catalyzes the hydrolyze of the acetyl group at the sn-2 position of PAF and its analogs and modulates the action of PAF. The activity and substrate specificity of PAF-AH (I) are affected by its subunit composition. Both alpha1/alpha1 homodimer (PAFAH1B3/PAFAH1B3 homodimer) and alpha1/alpha2 heterodimer(PAFAH1B3/PAFAH1B2 heterodimer) hydrolyze 1-O-alkyl-2-acetyl-sn-glycero-3-phosphoric acid (AAGPA) more efficiently than PAF, but they have little hydrolytic activity towards 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylethanolamine (AAGPE). Plays an important role during the development of brain. {ECO:0000250|UniProtKB:Q29460}.
uniprot
proteins
mass_dalton
25734
uniprot
proteins
protein_family
'GDSL' lipolytic enzyme family
uniprot
proteins
protein_family
Platelet-activating factor acetylhydrolase IB beta/gamma subunits subfamily
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
7669037
uniprot
proteins
sequence_length
231
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins