Bub3
entrez
12237
canonical
uniprot
Q9WVA3
canonical
ensembl
ENSMUSG00000066979
resolver
ensp
ENSMUSP00000081547
resolver
ensp
ENSMUSP00000309598
resolver
enst
ENSMUST00000084502
resolver
genesymbol
Bub3
resolver
uniprot
P97397
resolver
uniprot
Q6ZWM5
resolver
uniprot_entry
BUB3_MOUSE
resolver
uniprot_sec
P97397
resolver
uniprot_sec
Q6ZWM5
resolver
amino_acid_sequence
MTGSNEFKLNQPPEDGISSVKFSPNTSQFLLVSSWDTSVRLYDVPANSMRLKYQHTGAVLDCAFYDPTHAWSGGLDHQLKMHDLNTDQENLVGTHDAPIRCVEYCPEVNVMVTGSWDQTVKLWDPRTPCNAGTFSQPEKVYTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRRESSLKYQTRCIRAFPNKQGYVLSSIEGRVAVEYLDPSPEVQKKKYAFKCHRLKENNIEQIYPVNAISFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTTLAIASSYMYEMDDTEHPEDGIFIRQVTDAETKPKST
uniprot
proteins
function
FUNCTION: Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1 (By similarity). Regulates chromosome segregation during oocyte meiosis. {ECO:0000250, ECO:0000269|PubMed:19888327}.
uniprot
proteins
mass_dalton
36955
uniprot
proteins
post_translational_modification
PTM: Poly-ADP-ribosylated by PARP1. {ECO:0000269|PubMed:12011073}.; PTM: Ubiquitinated by UBR5, promoting disassembly of the mitotic checkpoint complex from the APC/C complex. {ECO:0000250|UniProtKB:O43684}.
uniprot
proteins
protein_family
WD repeat BUB3 family
uniprot
proteins
pubmed
10411903
uniprot
proteins
pubmed
12011073
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19888327
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
326
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:19888327}. Note=Starts to localize at kinetochores in prometaphase I (Pro-MI) stage and maintains the localization until the metaphase I-anaphase I (MI-AI) transition. {ECO:0000250}.
uniprot
proteins