Kmt5c
entrez
308345
canonical
uniprot
P0C2N6
canonical
ensembl
ENSRNOG00000017508
resolver
ensembl
ENSRNOG00055014386
resolver
ensembl
ENSRNOG00060026588
resolver
ensembl
ENSRNOG00065032308
resolver
ensp
ENSRNOP00000023744
resolver
ensp
ENSRNOP00055020174
resolver
ensp
ENSRNOP00060038235
resolver
ensp
ENSRNOP00065045786
resolver
enst
ENSRNOT00000023744
resolver
enst
ENSRNOT00055024693
resolver
enst
ENSRNOT00060046045
resolver
enst
ENSRNOT00065055620
resolver
genesymbol
Kmt5c
resolver
genesymbol_syn
Suv420h2
resolver
uniprot_entry
KMT5C_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by 6,7-Dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine (A-196). {ECO:0000250|UniProtKB:Q86Y97}.
uniprot
proteins
amino_acid_sequence
MGPDRVTARELCENDDLATSLVLDPYLGFRTHKMNVSPVPTLRRQHHLRSALEAFLRQRDLEAAFRALTLGGWMAHYFQNRAPRQEAALKNHIFCYLRAFLPESGFTILPCTRYSMETNGAKIVSTRAWKKNEKLELLVGCIAELREEDEYLLRAGENDFSVMYSTRKRSAQLWLGPAAFINHDCKPNCKFVPSDGNTACVKVLRDIEPGDEVTCFYGEGFFGEKNEHCECYTCERKGEGAFRLQPREPELRPRPLDKYELRETKRRLQQCLDSSQQNLLSLRACSHLSPLRPDPFCAACQPSCLLPVSPHMDYLPLWLQWVPQPQPRVRPRKRRRRRRRRPRIPQASLSPDLHTACVSLHRWGGCGPHCQLRAEAMVTLHLLPQTRWTPKQDWYWARRYGLPSVVRVELSPLAPALPAAPAPAGNLGPTPTPDLIPKQALAFAPFCPPKRLRLVVSHGSIDLDINSGEP
uniprot
proteins
ec_number
2.1.1.361
uniprot
proteins
ec_number
2.1.1.362
uniprot
proteins
function
FUNCTION: Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity. In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (By similarity). H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5C is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity). Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ)-directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (By similarity). {ECO:0000250|UniProtKB:Q6Q783, ECO:0000250|UniProtKB:Q86Y97}.
uniprot
proteins
mass_dalton
53607
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
Histone-lysine methyltransferase family
uniprot
proteins
protein_family
Suvar4-20 subfamily
uniprot
proteins
pubmed
16497704
uniprot
proteins
pubmed
17182829
uniprot
proteins
sequence_length
470
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Chromosome. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin.
uniprot
proteins