TIGIT
entrez
201633
canonical
uniprot
Q495A1
canonical
ensembl
ENSG00000181847
resolver
ensp
ENSP00000373167
resolver
ensp
ENSP00000561161
resolver
genesymbol
TIGIT
resolver
genesymbol_syn
VSIG9
resolver
genesymbol_syn
VSTM3
resolver
hgnc
HGNC:26838
resolver
uniprot
Q495A3
resolver
uniprot
Q5JPD8
resolver
uniprot
Q6MZS2
resolver
uniprot
Q8N877
resolver
uniprot_entry
TIGIT_HUMAN
resolver
uniprot_sec
Q495A3
resolver
uniprot_sec
Q5JPD8
resolver
uniprot_sec
Q6MZS2
resolver
uniprot_sec
Q8N877
resolver
amino_acid_sequence
MRWCLLLIWAQGLRQAPLASGMMTGTIETTGNISAEKGGSIILQCHLSSTTAQVTQVNWEQQDQLLAICNADLGWHISPSFKDRVAPGPGLGLTLQSLTVNDTGEYFCIYHTYPDGTYTGRIFLEVLESSVAEHGARFQIPLLGAMAATLVVICTAVIVVVALTRKKKALRIHSVEGDLRRKSAGQEEWSPSAPSPPGSCVQAEAAPAGLCGEQRGEDCAELHDYFNVLSYRSLGNCSFFTETG
uniprot
proteins
function
FUNCTION: Inhibitory receptor that plays a role in the modulation of immune responses. Suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells (PubMed:19011627). Upon binding to its ligands PVR/CD155 or NECTIN2/CD112, which are expressed on antigen-presenting cells, sends inhibitory signals to the T-cell or NK cell. Mechanistically, interaction with ligand leads to phosphorylation of the cytoplasmic tail by Src family tyrosine kinases such as FYN or LCK, allowing subsequent binding to adapter GRB2 and SHIP1/INPP5D. In turn, inhibits PI3K and MAPK signaling cascades (PubMed:23154388). In addition, associates with beta-arrestin-2/ARRB2 to recruit SHIP1/INPP5D that suppresses autoubiquitination of TRAF6 and subsequently inhibits NF-kappa-B signaling pathway (PubMed:24817116). Also acts as a receptor for NECTIN4 to inhibit NK cell cytotoxicity (PubMed:32503945). {ECO:0000269|PubMed:19011627, ECO:0000269|PubMed:23154388, ECO:0000269|PubMed:24817116, ECO:0000269|PubMed:32503945}.
uniprot
proteins
mass_dalton
26319
uniprot
proteins
mutagenesis
MUTAGEN 42; /note="I->A: Abrogates interaction with PVR, cell clustering and PVR signaling."; /evidence="ECO:0000269|PubMed:22421438"; MUTAGEN 42; /note="I->D: Abrogates interaction with PVR, cell clustering and PVR signaling."; /evidence="ECO:0000269|PubMed:22421438"; MUTAGEN 225; /note="Y->A: Complete loss of phosphorylation."; /evidence="ECO:0000269|PubMed:23154388"; MUTAGEN 227; /note="N->Q: Complete loss of binding to GRB2."; /evidence="ECO:0000269|PubMed:23154388"; MUTAGEN 231; /note="Y->A: No loss of phosphorylation."; /evidence="ECO:0000269|PubMed:23154388
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19011627
uniprot
proteins
pubmed
22421438
uniprot
proteins
pubmed
23154388
uniprot
proteins
pubmed
24817116
uniprot
proteins
pubmed
32503945
uniprot
proteins
sequence_length
244
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19011627, ECO:0000269|PubMed:23154388}; Single-pass type I membrane protein {ECO:0000269|PubMed:19011627}. Note=Clustered to the immunological synapse where it disrupts granule polarization and cytotoxicity of NK cells once engaged with PVR. {ECO:0000269|PubMed:23154388}.
uniprot
proteins
transmembrane_region
TRANSMEM 142..162; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins