Tlk2
entrez
24086
canonical
uniprot
O55047
canonical
ensembl
ENSMUSG00000020694
resolver
ensp
ENSMUSP00000015107
resolver
ensp
ENSMUSP00000090198
resolver
ensp
ENSMUSP00000102552
resolver
ensp
ENSMUSP00000102554
resolver
ensp
ENSMUSP00000118520
resolver
ensp
ENSMUSP00000275122
resolver
ensp
ENSMUSP00000275123
resolver
ensp
ENSMUSP00000275125
resolver
ensp
ENSMUSP00000275131
resolver
ensp
ENSMUSP00000275133
resolver
ensp
ENSMUSP00000275136
resolver
ensp
ENSMUSP00000275142
resolver
ensp
ENSMUSP00000275144
resolver
enst
ENSMUST00000106941
resolver
enst
ENSMUST00000145048
resolver
genesymbol
Tlk2
resolver
genesymbol_syn
Tlk
resolver
uniprot
B1ASU7
resolver
uniprot
B1ASU8
resolver
uniprot
B1ASU9
resolver
uniprot
B7ZC85
resolver
uniprot
Q6NZC4
resolver
uniprot
Q9D5Y5
resolver
uniprot_entry
B1ASU9_MOUSE
resolver
uniprot_entry
B7ZC85_MOUSE
resolver
uniprot_entry
Q6NZC4_MOUSE
resolver
uniprot_entry
TLK2_MOUSE
resolver
uniprot_sec
B1ASU7
resolver
uniprot_sec
B1ASU8
resolver
uniprot_sec
Q9D5Y5
resolver
activity_regulation
ACTIVITY REGULATION: Cell cycle-regulated, with maximal activity in the S-phase. Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase, probably by CHEK1, possibly at Ser-696. This inhibition is cell cycle checkpoint- and ATM-dependent. {ECO:0000250|UniProtKB:Q86UE8}.
uniprot
proteins
amino_acid_sequence
MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEKKQNDQRNRKRKAEPYDTSQGKGTPRGHKISDYFERRAEQPLYGLDGSAAKEASEEQSALPTLMSVMLAKPRLDTEQLAPRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation (By similarity). Phosphorylates the chromatin assembly factors ASF1A and ASF1B (By similarity). Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly (By similarity). Negative regulator of amino acid starvation-induced autophagy (By similarity). {ECO:0000250|UniProtKB:Q86UE8}.; FUNCTION: Testis-specific isoforms may play a role in spermatogenesis. Highly expressed in embryos throughout development. {ECO:0000269|PubMed:10092119}.
uniprot
proteins
mass_dalton
82261
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-696, probably by CHEK1. {ECO:0000250}.; PTM: Autophosphorylated; phosphorylation promotes the assembly of higher order oligomers and enzymatic activity. {ECO:0000250|UniProtKB:Q86UE8}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Ser/Thr protein kinase family
uniprot
proteins
pubmed
10092119
uniprot
proteins
pubmed
10455159
uniprot
proteins
pubmed
10523312
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
718
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10455159}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q86UE8}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:10455159}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10455159}. Note=Colocalizes with the cytoplasmic intermediate filament system during the G1 phase of the cell cycle. Present in the perinuclear region at S phase and in the nucleus at late G2. {ECO:0000269|PubMed:10455159}.
uniprot
proteins