ARHGEF26
entrez
26084
canonical
uniprot
Q96DR7
canonical
ensembl
ENSG00000114790
resolver
ensembl
ENSG00000277101
resolver
ensp
ENSP00000348828
resolver
ensp
ENSP00000423418
resolver
ensp
ENSP00000424446
resolver
ensp
ENSP00000559576
resolver
ensp
ENSP00000706752
resolver
genesymbol
ARHGEF26
resolver
genesymbol_syn
SGEF
resolver
hgnc
HGNC:24490
resolver
uniprot
A0A140VJU4
resolver
uniprot
B3KVP8
resolver
uniprot
B3KXG0
resolver
uniprot
E9PBD0
resolver
uniprot
Q68CL1
resolver
uniprot
Q6AZ96
resolver
uniprot
Q6Q8Q8
resolver
uniprot
Q96AW8
resolver
uniprot
Q96DR6
resolver
uniprot
Q9H9D7
resolver
uniprot
Q9H9R2
resolver
uniprot
Q9UFW5
resolver
uniprot_entry
A0A140VJU4_HUMAN
resolver
uniprot_entry
ARHGQ_HUMAN
resolver
uniprot_entry
B3KXG0_HUMAN
resolver
uniprot_sec
B3KVP8
resolver
uniprot_sec
E9PBD0
resolver
uniprot_sec
Q68CL1
resolver
uniprot_sec
Q6AZ96
resolver
uniprot_sec
Q6Q8Q8
resolver
uniprot_sec
Q96AW8
resolver
uniprot_sec
Q96DR6
resolver
uniprot_sec
Q9H9D7
resolver
uniprot_sec
Q9H9R2
resolver
uniprot_sec
Q9UFW5
resolver
amino_acid_sequence
MDGESEVDFSSNSITPLWRRRSIPQPHQVLGRSKPRPQSYQSPNGLLITDFPVEDGGTLLAAQIPAQVPTASDSRTVHRSPLLLGAQRRAVANGGTASPEYRAASPRLRRPKSPKLPKAVPGGSPKSPANGAVTLPAPPPPPVLRPPRTPNAPAPCTPEEDLTGLTASPVPSPTANGLAANNDSPGSGSQSGRKAKDPERGLFPGPQKSSSEQKLPLQRLPSQENELLENPSVVLSTNSPAALKVGKQQIIPKSLASEIKISKSNNQNVEPHKRLLKVRSMVEGLGGPLGHAGEESEVDNDVDSPGSLRRGLRSTSYRRAVVSGFDFDSPTSSKKKNRMSQPVLKVVMEDKEKFSSLGRIKKKMLKGQGTFDGEENAVLYQNYKEKALDIDSDEESEPKEQKSDEKIVIHHKPLRSTWSQLSAVKRKGLSQTVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKNSKELSDTMTKTERHHLFSNITDVCEASKKFFIELEARHQNNIFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLATNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKRALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELTAYVEDTVLFSRRTSKQQVYFFLFNDVLIITKKKSEESYNVNDYSLRDQLLVESCDNEELNSSPGKNSSTMLYSRQSSASHLFTLTVLSNHANEKVEMLLGAETQSERARWITALGHSSGKPPADRTSLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWFPMECAKEITCQATIDKNVERMGRLLGLETNV
uniprot
proteins
function
FUNCTION: Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17074883, ECO:0000269|PubMed:17875742}.
uniprot
proteins
mass_dalton
97346
uniprot
proteins
mutagenesis
MUTAGEN 826; /note="W->R: Fails to localize at sites of membrane ruffling."; /evidence="ECO:0000269|PubMed:15133129
uniprot
proteins
pubmed
12697679
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15133129
uniprot
proteins
pubmed
15221005
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17074883
uniprot
proteins
pubmed
17875742
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
871
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, ruffle {ECO:0000269|PubMed:15133129, ECO:0000269|PubMed:17875742}.
uniprot
proteins