Gpr37
entrez
14763
canonical
uniprot
Q9QY42
canonical
ensembl
ENSMUSG00000039904
resolver
ensp
ENSMUSP00000052185
resolver
genesymbol
Gpr37
resolver
uniprot
Q8BKF8
resolver
uniprot
Q8BXP9
resolver
uniprot
Q8C022
resolver
uniprot
Q9Z0G3
resolver
uniprot_entry
GPR37_MOUSE
resolver
uniprot_sec
Q8BKF8
resolver
uniprot_sec
Q8BXP9
resolver
uniprot_sec
Q8C022
resolver
uniprot_sec
Q9Z0G3
resolver
amino_acid_sequence
MPARGAPLSRTSRLLLLLLFKVSVSAALSFVPEPRNGTCLGESCSPLIQRRSRDARGPGNSAKDALRVHVPREKLEAEVRGATSWDLPPPRGGDTGVIEEAAAAGPLGPPTKPPSAWRWKSAQGKEPSGHLRRRDPTDPQLFFPTSEGGEMSSKRDGIPQSRQEHSVKTEPRDLFYWPRRTGQLQDSQHRPSAVHEGRTLAPPGRALPQNGSADDWVPDQGGPRRGNTTRRVRLKNPFYPLTQESYGAYAVMCLSVVIFGTGIIGNLAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLEDFSCKIVPYIEVASLGVTTFTLCALCIDRFRAATNVQMYYEMIENCSSTTAKLAVIWVGALLLALPEVVLRQLSKEDLGFSGQAPAERCVIKISPDLPDTIYVLALTYDGARLWWYFGCYFCLPTLFTITCSLVTARKIRKAEKASTRGNKRQIHLESQMNCTVVALTILYGFCIIPENICNIVTAYMATGVSQQTMDLLNIISQFLLFFKSCVTPVLLFCLCRPFSRAFMECCCCCCEECIQKSSTVTSDDNDNEYTTELELSPFSTIRREMSTFASVGTHC
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that plays a role in several physiological pathways such as resolution of inflammatory pain and oligodendrocyte differentiation (PubMed:26961174, PubMed:28642167, PubMed:30010619). Acts as a receptor for several ligands including prosaposin, osteocalcin or neuroprotectin D1. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade (By similarity). Acts as a receptor for osteocalcin (OCN) to regulate oligodendrocyte differentiation and central nervous system myelination (PubMed:34678058). Mechanistically, plays a negative role in oligodendrocyte differentiation and myelination during development via activation of the ERK1/2 signaling pathway (PubMed:26961174). Therefore, regulates the stability of myelin or resistance of myelin itself to demyelination (PubMed:28642167). Upon activation by neuroprotectin D1 (NPD1), promotes the activation of phagocytosis in macrophages as well as the shift in cytokine release toward an anti-inflammatory profile, and thus helps to reverse inflammatory pain (PubMed:30010619). In addition, the increased macrophage phagocytosis mediates protection against sepsis upon pathogen infection (PubMed:33731716). Additionally, extracellular vesicles derived from efferocyte express prosaposin, which binds to macrophage GPR37 to increase expression of the efferocytosis receptor TIM4 via an ERK-AP1-dependent signaling axis, leading to increased macrophage efferocytosis efficiency and accelerated resolution of inflammation (PubMed:37436891). May also act as a maturation factor of LRP6, protecting LRP6 from the endoplasmic reticulum (ER)-associated protein degradation (ERAD) and thereby promoting the Wnt/beta-catenin signaling pathway (By similarity). {ECO:0000250|UniProtKB:O15354, ECO:0000269|PubMed:26961174, ECO:0000269|PubMed:28642167, ECO:0000269|PubMed:30010619, ECO:0000269|PubMed:33731716, ECO:0000269|PubMed:34678058, ECO:0000269|PubMed:37436891}.
uniprot
proteins
mass_dalton
66775
uniprot
proteins
post_translational_modification
PTM: The N-terminus is cleaved by ADAM10 metalloproteinase; mediating limited proteolysis leading to the release of receptor ectodomain by shedding. In addition, cleaved by FURIN between Arg-53 and Asp-54. {ECO:0000250|UniProtKB:O15354}.; PTM: Ubiquitinated by PRKN in the presence of UBE2E1 and UBE2L3 in the endoplasmic reticulum. The unfolded form is specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation and prevents neuronal cell death. {ECO:0000250|UniProtKB:O15354}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
26961174
uniprot
proteins
pubmed
28642167
uniprot
proteins
pubmed
30010619
uniprot
proteins
pubmed
33731716
uniprot
proteins
pubmed
34678058
uniprot
proteins
pubmed
37436891
uniprot
proteins
pubmed
9799598
uniprot
proteins
sequence_length
600
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, dendrite {ECO:0000250|UniProtKB:O15354}. Synapse {ECO:0000250|UniProtKB:O15354}. Cell membrane {ECO:0000250|UniProtKB:O15354}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O15354}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O15354}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O15354}.
uniprot
proteins
transmembrane_region
TRANSMEM 253..273; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 287..307; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 323..343; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 367..387; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 431..451; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 481..501; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 519..539; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins