TESPA1
entrez
9840
canonical
uniprot
A2RU30
canonical
ensembl
ENSG00000135426
resolver
ensp
ENSP00000312679
resolver
ensp
ENSP00000400892
resolver
ensp
ENSP00000432030
resolver
ensp
ENSP00000433098
resolver
ensp
ENSP00000435622
resolver
ensp
ENSP00000538717
resolver
genesymbol
TESPA1
resolver
genesymbol_syn
KIAA0748
resolver
hgnc
HGNC:29109
resolver
uniprot
B4DHC1
resolver
uniprot
B4DPM3
resolver
uniprot
B4E048
resolver
uniprot
B7Z9K7
resolver
uniprot
O94849
resolver
uniprot
Q4G0P2
resolver
uniprot
Q9P0C4
resolver
uniprot_entry
B4DHC1_HUMAN
resolver
uniprot_entry
TESP1_HUMAN
resolver
uniprot_sec
B4DPM3
resolver
uniprot_sec
B4E048
resolver
uniprot_sec
B7Z9K7
resolver
uniprot_sec
O94849
resolver
uniprot_sec
Q4G0P2
resolver
uniprot_sec
Q9P0C4
resolver
amino_acid_sequence
MEASVLSPTSWEKRRAWLRQSRNWQTQVLEEEAAAALQDVPDPEPSSLDDVFQEGNPINKIEDWLQDCGYSEEGFSEEAGQFIYNGFCSHGTSFEDDLTLGAEATLLAANGKLFSRSFLETARPCQLLDLGCSLASSSMTGGTNKTSSSISEILDKVQEDAEDVLFSLGFGQEDHKDTSRIPARFFTTPSQAKGIDFQLFLKSQVRRIEMEDPCLMLASRFKQVQTLAVTADAFFCLYSYVSKTPVQKFTPSHMFWNCNHPTDVPSIRILSREPEPQSPRDRLRKAISKMCLYTCPRDRPPPPHNTPKRNSLDQVVLEVMDKVKEEKQFLQQDSDLGQFSQEDPVPPAEGKKLPTSPYPCVFCCEEETQQRMSTVLAPSQTLDSNPKVPCCTHSLPIEDPQWSTDPAQIRRELCSLPATNTETHPAKDETFWKRKSRARKSLFQKNLMGRKVKSLDLSITQQKWKQSVDRPELRRSLSQQPQDTFDLEEVQSNSEEEQSQSRWPSRPRHPHHHQTFAGKDS
uniprot
proteins
function
FUNCTION: Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development (By similarity). Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment. {ECO:0000250, ECO:0000269|PubMed:22561606}.
uniprot
proteins
mass_dalton
59213
uniprot
proteins
mutagenesis
MUTAGEN 185; /note="F->A: Loss of ITPR1-binding."; /evidence="ECO:0000269|PubMed:23650607"; MUTAGEN 186; /note="F->A: Strong decrease in ITPR1-binding. Complete loss of ITPR1-binding; when associated with A-185."; /evidence="ECO:0000269|PubMed:23650607
uniprot
proteins
post_translational_modification
PTM: May be phosphorylated in response to store-operated Ca(+2) entry. {ECO:0000250}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
22561606
uniprot
proteins
pubmed
23501103
uniprot
proteins
pubmed
23650607
uniprot
proteins
pubmed
9872452
uniprot
proteins
sequence_length
521
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22561606, ECO:0000269|PubMed:23501103}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23501103}. Note=May localize to mitochondria-associated endoplasmic reticulum membrane (MAM). {ECO:0000269|PubMed:23501103}.
uniprot
proteins