Rab40c
entrez
224624
canonical
uniprot
Q8VHQ4
canonical
ensembl
ENSMUSG00000025730
resolver
ensp
ENSMUSP00000026826
resolver
ensp
ENSMUSP00000127546
resolver
enst
ENSMUST00000026826
resolver
enst
ENSMUST00000167626
resolver
genesymbol
Rab40c
resolver
genesymbol_syn
Rab40C
resolver
uniprot
Q0PD11
resolver
uniprot_entry
Q0PD11_MOUSE
resolver
uniprot_entry
RB40C_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) including DAB2IP, which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000250|UniProtKB:Q96S21}.
uniprot
proteins
amino_acid_sequence
MGTQGSPVKSYDYLLKFLLVGDSDVGKGEILESLQDGAAESPYAYSNGIDYKTTTILLDGRRVKLELWDTSGQGRFCTIFRSYSRGAQGILLVYDITNRWSFDGIDRWIKEIDEHAPGVPRILVGNRLHLAFKRQVPTEQARAYAEKNCMTFFEVSPLCNFNVIESFTELSRIVLMRHGMEKIWRPNRVFSLQDLCCRAIVSCTPVHLIDKLPLPVTIKSHLKSFSMANGMNAVMMHGRSYSLASGAGGSGSKGNSLKRSKSIRPPQSPPQNCSRSNCKIS
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: RAB40C small GTPase acts as substrate-recognition component of the ECS(RAB40C) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Rab40 subfamily belongs to the Rab family that are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration. Also negatively regulate lipid droplets accumulation in a GTP-dependent manner. {ECO:0000250|UniProtKB:Q96S21}.
uniprot
proteins
mass_dalton
31348
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
281
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q96S21}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q96S21}. Note=Mostly localized in the cytosol and also with actin ruffles. {ECO:0000250|UniProtKB:Q96S21}.
uniprot
proteins