APOC3
entrez
345
canonical
uniprot
P02656
canonical
ensembl
ENSG00000110245
resolver
ensp
ENSP00000227667
resolver
ensp
ENSP00000533843
resolver
ensp
ENSP00000533844
resolver
ensp
ENSP00000533845
resolver
ensp
ENSP00000533846
resolver
ensp
ENSP00000533847
resolver
ensp
ENSP00000533848
resolver
ensp
ENSP00000533849
resolver
ensp
ENSP00000533850
resolver
ensp
ENSP00000533851
resolver
ensp
ENSP00000533852
resolver
ensp
ENSP00000533853
resolver
ensp
ENSP00000533854
resolver
ensp
ENSP00000533855
resolver
ensp
ENSP00000533857
resolver
ensp
ENSP00000533860
resolver
ensp
ENSP00000533861
resolver
ensp
ENSP00000533862
resolver
ensp
ENSP00000533864
resolver
ensp
ENSP00000533865
resolver
enst
ENST00000227667
resolver
enst
ENST00000863784
resolver
enst
ENST00000863785
resolver
enst
ENST00000863786
resolver
enst
ENST00000863787
resolver
enst
ENST00000863788
resolver
enst
ENST00000863789
resolver
enst
ENST00000863790
resolver
enst
ENST00000863791
resolver
enst
ENST00000863792
resolver
enst
ENST00000863793
resolver
enst
ENST00000863794
resolver
enst
ENST00000863795
resolver
enst
ENST00000863796
resolver
enst
ENST00000863798
resolver
enst
ENST00000863801
resolver
enst
ENST00000863802
resolver
enst
ENST00000863803
resolver
enst
ENST00000863805
resolver
enst
ENST00000863806
resolver
genesymbol
APOC3
resolver
hgnc
HGNC:610
resolver
uniprot
A3KPE2
resolver
uniprot
Q08E83
resolver
uniprot
Q6Q786
resolver
uniprot_entry
A3KPE2_HUMAN
resolver
uniprot_entry
APOC3_HUMAN
resolver
uniprot_sec
Q08E83
resolver
uniprot_sec
Q6Q786
resolver
amino_acid_sequence
MQPRVLLVVALLALLASARASEAEDASLLSFMQGYMKHATKTAKDALSSVQESQVAQQARGWVTDGFSSLKDYWSTVKDKFSEFWDLDPEVRPTSAVAA
uniprot
proteins
disease_involvement
DISEASE: Hyperalphalipoproteinemia 2 (HALP2) [MIM:614028]: A condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels. {ECO:0000269|PubMed:2022742}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma (PubMed:18201179, PubMed:22510806). Plays a multifaceted role in triglyceride homeostasis (PubMed:18201179, PubMed:22510806). Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs) (PubMed:18201179, PubMed:22510806). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors (PubMed:18201179, PubMed:22510806). Formed of several curved helices connected via semiflexible hinges, so that it can wrap tightly around the curved micelle surface and easily adapt to the different diameters of its natural binding partners (PubMed:18408013). {ECO:0000269|PubMed:18408013, ECO:0000303|PubMed:18201179, ECO:0000303|PubMed:22510806}.
uniprot
proteins
mass_dalton
10852
uniprot
proteins
post_translational_modification
PTM: The most abundant glycoforms are characterized by an O-linked disaccharide galactose linked to N-acetylgalactosamine (Gal-GalNAc), further modified with up to 3 sialic acid residues. Less abundant glycoforms are characterized by more complex and fucosylated glycan moieties. O-glycosylated on Thr-94 with a core 1 or possibly core 8 glycan. {ECO:0000269|PubMed:19838169, ECO:0000269|PubMed:23527852, ECO:0000269|PubMed:3123586}.
uniprot
proteins
protein_family
Apolipoprotein C3 family
uniprot
proteins
pubmed
15108119
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18201179
uniprot
proteins
pubmed
18408013
uniprot
proteins
pubmed
19838169
uniprot
proteins
pubmed
2022742
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22510806
uniprot
proteins
pubmed
23527852
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2989400
uniprot
proteins
pubmed
3123586
uniprot
proteins
pubmed
3949020
uniprot
proteins
pubmed
4846755
uniprot
proteins
pubmed
6328445
uniprot
proteins
pubmed
6439535
uniprot
proteins
pubmed
6548954
uniprot
proteins
sequence_length
99
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:18201179, ECO:0000303|PubMed:22510806}.
uniprot
proteins