Snca
entrez
29219
canonical
uniprot
P37377
canonical
ensembl
ENSRNOG00000008656
resolver
ensembl
ENSRNOG00055011495
resolver
ensembl
ENSRNOG00060022503
resolver
ensembl
ENSRNOG00065011697
resolver
ensp
ENSRNOP00000030609
resolver
ensp
ENSRNOP00000081453
resolver
genesymbol
Snca
resolver
uniprot
P37378
resolver
uniprot
Q53YM9
resolver
uniprot_entry
SYUA_RAT
resolver
uniprot_sec
P37378
resolver
uniprot_sec
Q53YM9
resolver
amino_acid_sequence
MDVFMKGLSKAKEGVVAAAEKTKQGVAEAAGKTKEGVLYVGSKTKEGVVHGVTTVAEKTKEQVTNVGGAVVTGVTAVAQKTVEGAGNIAAATGFVKKDQMGKGEEGYPQEGILEDMPVDPSSEAYEMPSEEGYQDYEPEA
uniprot
proteins
function
FUNCTION: Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release (By similarity). Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (By similarity). Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (By similarity). Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (By similarity). This chaperone activity is important to sustain normal SNARE-complex assembly during aging (By similarity). Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (By similarity). {ECO:0000250|UniProtKB:P37840}.
uniprot
proteins
mass_dalton
14515
uniprot
proteins
post_translational_modification
PTM: Phosphorylated, predominantly on serine residues. Phosphorylated on Tyr-125 upon osmotic stress. {ECO:0000250|UniProtKB:P37840}.; PTM: Ubiquitinated. The predominant conjugate is the diubiquitinated form. {ECO:0000269|PubMed:12408865}.; PTM: Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure. {ECO:0000250|UniProtKB:P37840}.
uniprot
proteins
protein_family
Synuclein family
uniprot
proteins
pubmed
10582622
uniprot
proteins
pubmed
12408865
uniprot
proteins
pubmed
12665621
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1661825
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
3411354
uniprot
proteins
sequence_length
140
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P37840}. Membrane {ECO:0000250|UniProtKB:P37840}. Nucleus {ECO:0000250|UniProtKB:P37840}. Synapse {ECO:0000250|UniProtKB:P37840}. Secreted {ECO:0000250|UniProtKB:P37840}. Cell projection, axon {ECO:0000250|UniProtKB:O55042}. Note=Membrane-bound in dopaminergic neurons (By similarity). Expressed and colocalized with SEPTIN4 in dopaminergic axon terminals, especially at the varicosities (By similarity). {ECO:0000250|UniProtKB:O55042, ECO:0000250|UniProtKB:P37840}.
uniprot
proteins