Tnp1
entrez
21958
canonical
uniprot
P10856
canonical
ensembl
ENSMUSG00000026182
resolver
ensp
ENSMUSP00000027374
resolver
enst
ENSMUST00000027374
resolver
genesymbol
Tnp1
resolver
uniprot
Q545L6
resolver
uniprot_entry
Q545L6_MOUSE
resolver
uniprot_entry
STP1_MOUSE
resolver
amino_acid_sequence
MSTSRKLKTHGMRRGKNRAPHKGVKRGGSKRKYRKSVLKSRKRGDDASRNYRSHL
uniprot
proteins
function
FUNCTION: Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals (PubMed:10781074, PubMed:15083521, PubMed:15163613, PubMed:15189834, PubMed:28366643). In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction (PubMed:28366643). The histone H2AB1-H2BC1/TH2B dimer is required for loading of TNP1 onto chromatin (PubMed:28366643). {ECO:0000269|PubMed:10781074, ECO:0000269|PubMed:15083521, ECO:0000269|PubMed:15163613, ECO:0000269|PubMed:15189834, ECO:0000269|PubMed:28366643}.
uniprot
proteins
mass_dalton
6407
uniprot
proteins
protein_family
Nuclear transition protein 1 family
uniprot
proteins
pubmed
10781074
uniprot
proteins
pubmed
15083521
uniprot
proteins
pubmed
15163613
uniprot
proteins
pubmed
15189834
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1685480
uniprot
proteins
pubmed
28366643
uniprot
proteins
pubmed
3382664
uniprot
proteins
sequence_length
55
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15163613}. Chromosome {ECO:0000269|PubMed:28366643}. Note=Loaded onto the nucleosomes of condensing spermatids (PubMed:28366643). Inclusion of the H2AB1-H2BC1/TH2B dimer into chromatin opens the nucleosomes, releasing the nucleosomal DNA ends and allowing the invasion of nucleosomes by transition protein TNP1 (PubMed:28366643). {ECO:0000269|PubMed:28366643}.
uniprot
proteins