Galnt1
entrez
79214
canonical
uniprot
Q10473
canonical
ensembl
ENSRNOG00000016207
resolver
ensembl
ENSRNOG00055018123
resolver
ensembl
ENSRNOG00060012241
resolver
ensembl
ENSRNOG00065015137
resolver
ensp
ENSRNOP00000022117
resolver
ensp
ENSRNOP00055024716
resolver
ensp
ENSRNOP00060016362
resolver
ensp
ENSRNOP00065019627
resolver
enst
ENSRNOT00000022117
resolver
enst
ENSRNOT00055030725
resolver
enst
ENSRNOT00060020767
resolver
enst
ENSRNOT00065025076
resolver
genesymbol
Galnt1
resolver
uniprot_entry
GALT1_RAT
resolver
amino_acid_sequence
MRKFAYCKVVLATSLVWVLLDMFLLLYFSECNKCEEKKERGLPAGDVLELVQKPHEGPGEMGKPVVIPKEDQEKMKEMFKINQFNLMASEMIAFNRSLPDVRLEGCKTKVYPDSLPTTSVVIVFHNEAWSTLLRTVHSVINRSPRHMIEEIVLVDDASERDFLKRPLESYVKKLKVPVHVIRMEQRSGLIRARLKGAAVSKGQVITFLDAHCECTVGWLEPLLARIKHDRRTVVCPIIDVISDDTFEYMAGSDMTYGGFNWKLNFRWYPVPQREMDRRKGDRTLPVRTPTMAGGLFSIDRDYFQEIGTYDAGMDIWGGENLEISFRIWQCGGTLEIVTCSHVGHVFRKATPYTFPGGTGQIINKNNRRLAEVWMDEFKNFFYIISPGVTKVDYGDISSRVGLRHKLQCKPFSWYLENIYPDSQIPRHYFSLGEIRNVETNQCLDNMARKENEKVGIFNCHGMGGNQVFSYTANKEIRTDDLCLDVSKLNGPVTMLKCHHLKGNQLWEYDPVKLTLQHVNSNQCLDKATEEDSQVPSIRDCTGSRSQQWLLRNVTLPEIF
uniprot
proteins
ec_number
2.4.1.41
uniprot
proteins
function
FUNCTION: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor (PubMed:12199709, PubMed:12364335, PubMed:12419318). Has a broad spectrum of substrates such as apomucin-, MUC5AC-, MUC1- and MUC2-derived peptides (By similarity). {ECO:0000250|UniProtKB:Q10472, ECO:0000269|PubMed:12199709, ECO:0000269|PubMed:12364335, ECO:0000269|PubMed:12419318}.
uniprot
proteins
mass_dalton
64229
uniprot
proteins
mutagenesis
MUTAGEN 106; /note="C->A: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:12199709"; MUTAGEN 212; /note="C->A: Loss of enzyme activity due to absence of interaction between UDP moiety and UDP-GalNAC."; /evidence="ECO:0000269|PubMed:12199709"; MUTAGEN 214; /note="C->A: Loss of enzyme activity due to absence of interaction between UDP moiety and UDP-GalNAC."; /evidence="ECO:0000269|PubMed:12199709"; MUTAGEN 235; /note="C->A: No effect."; /evidence="ECO:0000269|PubMed:12199709"; MUTAGEN 330; /note="C->A: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:12199709"; MUTAGEN 339; /note="C->A: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:12199709"; MUTAGEN 408; /note="C->A: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:12199709"; MUTAGEN 442; /note="C->A: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:12364335"; MUTAGEN 444; /note="D->A: Induces a strong decrease in activity; loss of function; when associated with A-484 and A-525."; /evidence="ECO:0000269|PubMed:12364335, ECO:0000269|PubMed:12419318"; MUTAGEN 455; /note="G->Q: Induces a decrease in activity."; /evidence="ECO:0000269|PubMed:12364335"; MUTAGEN 457; /note="F->A: Little or no effect."; /evidence="ECO:0000269|PubMed:12364335"; MUTAGEN 459; /note="C->A: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:12364335"; MUTAGEN 465; /note="N->A: Little or no effect."; /evidence="ECO:0000269|PubMed:12364335"; MUTAGEN 466; /note="Q->A: Induces a decrease in activity."; /evidence="ECO:0000269|PubMed:12364335"; MUTAGEN 468; /note="F->A: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:12364335"; MUTAGEN 468; /note="F->W,Y: Little or no effect."; /evidence="ECO:0000269|PubMed:12364335"; MUTAGEN 482; /note="C->A: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:12364335"; MUTAGEN 484; /note="D->A: Loss of enzyme activity; when associated with A-444 and A-525."; /evidence="ECO:0000269|PubMed:12364335, ECO:0000269|PubMed:12419318"; MUTAGEN 497; /note="C->A: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:12364335"; MUTAGEN 523; /note="C->A: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:12364335"; MUTAGEN 525; /note="D->A: Loss of enzyme activity; when associated with A-444 and A-484."; /evidence="ECO:0000269|PubMed:12364335, ECO:0000269|PubMed:12419318"; MUTAGEN 540; /note="C->A: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:12364335
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:12199709, ECO:0000269|PubMed:12364335, ECO:0000269|PubMed:12419318}.
uniprot
proteins
protein_family
GalNAc-T subfamily
uniprot
proteins
protein_family
Glycosyltransferase 2 family
uniprot
proteins
pubmed
12199709
uniprot
proteins
pubmed
12364335
uniprot
proteins
pubmed
12419318
uniprot
proteins
pubmed
8748168
uniprot
proteins
sequence_length
559
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Polypeptide N-acetylgalactosaminyltransferase 1]: Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Polypeptide N-acetylgalactosaminyltransferase 1 soluble form]: Secreted {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..28; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins