A0A8I6ASZ5
uniprot
A0A8I6ASZ5
canonical
amino_acid_sequence
MSRRALRRLRGEQRGQEPLGPDALQFVLLDDDDAEEEGPKTGLGGRRPGGAGKEGVRVNNRFELINIEDLEDDLVVNGERSDCTLPDSASSGNKGRAKHGNPENKQDGDAAAKAGSSEQSNASGKLRKKKKKQKNKKSCTGESSENGLEDIDRILERIEDSSGFSHPGPPPLSSRKHVLYVEHRHLNPDTELKRYFGARAVLGEQRPRQRQRVYPKCTWLTTPKSTWPRYSKPGLSMRLLESKKGLSFFAFEHSEEYQQAQHKFLVAVESMEPNNIVALLQTSPYHVDSLLQLSDACRFQEDQEMARDLIGEPAYPHLLPMEKSWCRRPHWSFYLALYKQMSFLEKRGCPRTALEYCKLILSLEPDEDPLCMLLLIDHMALRARNYEYLIRLFQEWEAHRNLSQLPNFAFSVPLAYFLLSQQTDLPDHELSSARQQASLLIQQALTMFPGVLMPLLEYCSVRPDATVSNHRFFGPDAEISQPPALSQLVSLYLGRSHFLWKEPAIMSWLEENVHEVLEAVDSGDPAVEACENRRKVLYQRAPRNIHRHVILSEIKEAVAALPSDVTTQSVMGFDPLPPVDTIYSYVRPERLSPVSHGNTIALFFRSLLPNYTTEGERLEEGVAGGPNRNQGLNRLMLAVRDMMANFHFNDLEVPREDNPEGEGDWD
uniprot
proteins
function
FUNCTION: Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (By similarity). In the RQC complex, required to promote formation of 'Lys-48'-linked polyubiquitin chains during ubiquitination of incompletely synthesized proteins by LTN1 (By similarity). May negatively regulate the calcineurin-NFAT signaling cascade by suppressing the activity of transcription factor NFATC4 (PubMed:32805187). May play a role in cell death control (By similarity). {ECO:0000250|UniProtKB:Q8R3L2, ECO:0000250|UniProtKB:Q9BQ70, ECO:0000269|PubMed:32805187}.
uniprot
proteins
mass_dalton
75547
uniprot
proteins
protein_family
TCF25 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
32805187
uniprot
proteins
sequence_length
666
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:32805187}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9BQ70}. Note=Mainly nuclear. {ECO:0000269|PubMed:32805187}.
uniprot
proteins