Lrrc7
entrez
117284
canonical
uniprot
P70587
canonical
ensembl
ENSRNOG00000011980
resolver
ensp
ENSRNOP00000059517
resolver
ensp
ENSRNOP00000082626
resolver
ensp
ENSRNOP00000093706
resolver
enst
ENSRNOT00000066024
resolver
enst
ENSRNOT00000115389
resolver
genesymbol
Lrrc7
resolver
genesymbol_syn
Lap1
resolver
uniprot
A0A8I6G9P9
resolver
uniprot
F1M4K6
resolver
uniprot
Q9JI42
resolver
uniprot_entry
A0A8I6G9P9_RAT
resolver
uniprot_entry
F1M4K6_RAT
resolver
uniprot_entry
LRRC7_RAT
resolver
uniprot_sec
Q9JI42
resolver
amino_acid_sequence
MTTKRKLIGRLVPCRCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSSLPTSIASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFSELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPPTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQRLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQRVLTNYMFPQQPRGDEDFQSDSDSFNPTLWEEQRQQRMTVAFEFEDKKEDDESAGKVKALSCQAPWDRGQRGITLQPARLSGDCCTPWARCDQQIQDMPVPQSDPQLAWGCISGLQQERSMCAPLPVAAQSTTLPSLSGRQVEINLKRYPTPYPEDLKNMVKSVQNLVGKPSHGVRVENANPTANTEQTVKEKFEHKWPVAPKEITVEDSFVHPANEMRIGELHPSLAETPLYPPKLVLLGKDKKESTDESEVDKTHCLNNSVSSGTYSDYSPSQASSASSNTRVKVGSLQPTTKDAVHNSLWGNRIAPPFPQPLDAKPLLTQREAVPPGNLPQRPDRLPMSDAFPDNWTDGSHYDNTGFVSEEATGENANNNPLLSSKARSVPAHGRRPLIRQERIVGVPLELEQSTHRHTPETEVPPSNPWQNWTRTPSPFEDRTAFPSKLETTPTTSPLPERKDHMKEPTETPGPFSPGVPWEYHDPTPNRSLGNVFSQIHCRPDSSKGVIAISKSTERLSPLMKDIKSNKFKKSQSIDEIDVGTYKVYNIPLENYASGSDHLGSHERPDKFLGPEHGMSSMSRSQSVPMLDDEMLMYGSSKGPPQQKASMTKKVYQFDQSFNPQGAVEVKAEKRIPPPFAHNSEYVQQPGKNIAKDLVSPRAYRGYPPMEQMFSFSQPSVNEDAMVNAQFASQGPRAGFLRRADSLASSTEMAMFRRVSEPHELPPGDRYGRAAYRGGLEGQSSVSMTDPQFLKRNGRYEDEHPSYQEVKAQAGSFPAKNLTQRRPLSARSYSTESYGASQTRPVSARPTMAALLEKIPSDYNLGNYGDKTSDNSDIKTRPTPVKGEESCGKMPADWRQQLLRHIEARRLDRTPSQQSNILDNGQEDVSPSGQWNPYPLGRRDVPPDTITKKAGSHIQTLMGSQSLQHRSREQQPYEGNINKVTIQQFQSPLPIQIPSSQATRGPQPGRCLIQTKGQRSMDGYPEQFCVRIEKNPGLGFSISGGISGQGNPFKPSDKGIFVTRVQPDGPASNLLQPGDKILQANGHSFVHMEHEKAVLLLKSFQNTVDLVIQRELTV
uniprot
proteins
function
FUNCTION: Adapter protein that is required for correct postsynapse architecture and regulates postsynaptic plasticity through interactions with different partners (By similarity). Through its interaction with CACNA1C, it enhances trafficking of voltage-dependent L-type calcium channels to the dendritic cell membrane and increases channel postsynaptic clustering, thereby facilitating excitatory calcium signaling (By similarity). It also serves as a scaffold that brings CAMK2A and PPP1CA into close proximity, probably facilitating rapid dephosphorylation of CAMK2A by PPP1CA and influencing CAMK2A-mediated regulation of postsynaptic plasticity (By similarity). Necessary for DISC1 and GRM5 localization to postsynaptic density complexes and for both N-methyl D-aspartate receptor-dependent and metabotropic glutamate receptor-dependent long term synaptic depression (By similarity). {ECO:0000250|UniProtKB:Q80TE7, ECO:0000250|UniProtKB:Q96NW7}.
uniprot
proteins
mass_dalton
166879
uniprot
proteins
mutagenesis
MUTAGEN 1288; /note="S->D: Decrease in the level of phosphorylation. Strong decrease in the level of phosphorylation; when associated with D-1392."; /evidence="ECO:0000269|PubMed:10827168"; MUTAGEN 1392; /note="S->D: Strong decrease in the level of phosphorylation; when associated with D-1288."; /evidence="ECO:0000269|PubMed:10827168
uniprot
proteins
post_translational_modification
PTM: O-glycosylated and phosphorylated. {ECO:0000269|PubMed:8824323}.
uniprot
proteins
protein_family
LAP (LRR and PDZ) protein family
uniprot
proteins
pubmed
10827168
uniprot
proteins
pubmed
12390249
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
30325965
uniprot
proteins
pubmed
8824323
uniprot
proteins
sequence_length
1490
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96NW7}. Postsynaptic density {ECO:0000269|PubMed:30325965}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q96NW7}. Postsynapse {ECO:0000250|UniProtKB:Q96NW7}.
uniprot
proteins