Impg2
entrez
224224
canonical
uniprot
Q80XH2
canonical
ensembl
ENSMUSG00000035270
resolver
ensp
ENSMUSP00000063648
resolver
genesymbol
Impg2
resolver
uniprot
Q810Y3
resolver
uniprot
Q8C8E4
resolver
uniprot_entry
IMPG2_MOUSE
resolver
uniprot_sec
Q810Y3
resolver
uniprot_sec
Q8C8E4
resolver
amino_acid_sequence
MIMFLPVGRMSLGILILFLTGGNLVSASEERQEPMHAVSVLSPEKSTDLSLPTRKRQLLDATETGRRWLLRRRRSILFPNGVKICSSETVAEAVANHVKYFKARVCQEAIWEAFRTFWDRLPGRDEYRHWMNLCEDGVTSVFEMGAHFSQSVEHRNLIMKKLAYTREAESSSCKDQSCGPELSFPVPIGETSTLTGAVSSASYPGLASESSAASPQESISNEIENVTEEPTQPAAEQIAEFSIQLLGKRYSEELRDPSSALYRLLVEEFISEVEKAFTGLPGYKGIRVLEFRAPEENDSGIDVHYAVTFNGEAISNTTWDLISLHSNKVENHGLVEMDDKPTAVYTISNFRDYIAETLHQNFLMGNSSLNPDPKSLQLINVRGVLLPQTEDIVWNTQSSSLQVTTSSILDNTLQAEWLSADTTTTTTTTISPFGFSSSSPSATGRELQSQSALRDVVSTSKLASPTKVVLSSLPEILGGSSLTLHSVTPAVLQPDLPVAPEGRTSGSFILEDGLASTEELEDTSIDGLPSSPLIQPVPKETVPPMEDSDTALLSTPHLTSSAIEDLTKDIGTPSGLESLASNISDQLEVIPWFPDTSVEKDFIFESGLGSGSGKDVDVIDWPWSETSLEKTTKPLSKSWSEEQDALLPTEGREKLHIDGRVDSTEQIIESSEHRYGDRPIHFIEEESHVRSTIPIFVESATPPTSPIFSKHTSDVPDIDSYSLTKPPFLPVTIAIPASTKKTDEVLKEDMVHTESSSHKELDSEVPVSRPDMQPVWTMLPESDTVWTRTSSLGKLSRDTLASTPESTDRLWLKASMTQSTELPSTTHSTQLEEEVIMAVQDISLELDQVGTDYYQSELTEEQHGKADSYVEMSTSVHYTEMPIVALPTKGGVLSHTQTAGALVVFFSLRVTNMLFSEDLFNKNSLEYKALEQRFLELLVPYLQSNLSGFQNLEILSFRNGSIVVNSRVRFAESAPPNVNKAMYRILEDFCTTAYQTMNLDIDKYSLDVESGDEANPCKFQACNEFSECLVNPWSGEAKCKCYPGYLSVDELPCQSLCDLQPDFCLNDGKCDIMPGHGAICRCRVGSNWWYRGQHCEEFVSEPFVIGITIASVVSFLLVASAVVFFLVKMLQAQNVRRERQRPTSSSRHPDSLSSVENAMKYNPAYESHLAGCELYEKSYSQHPFYSSASEEVIGGLSREEIRQMYESSDLSKEEIQERMRILELYANDPEFAAFVREHQMEEL
uniprot
proteins
function
FUNCTION: Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix; may participate in the maturation and maintenance of the light-sensitive photoreceptor outer segment. Binds heparin. {ECO:0000250|UniProtKB:Q9BZV3}.
uniprot
proteins
mass_dalton
138102
uniprot
proteins
mutagenesis
MUTAGEN 255; /note="R->H: Decreased-binding affinity to hyaluronan."; /evidence="ECO:0000269|PubMed:15044457"; MUTAGEN 263; /note="R->H: Decreased-binding affinity to hyaluronan."; /evidence="ECO:0000269|PubMed:15044457"; MUTAGEN 1083; /note="R->Q: Decreased-binding affinity to hyaluronan."; /evidence="ECO:0000269|PubMed:15044457"; MUTAGEN 1091; /note="R->Q: Decreased-binding affinity to hyaluronan."; /evidence="ECO:0000269|PubMed:15044457"; MUTAGEN 1136..1139; /note="RRER->SSES: Most important decrease in binding affinity to hyaluronan."; /evidence="ECO:0000269|PubMed:15044457"; MUTAGEN 1147; /note="R->G: Important decrease in binding affinity to hyaluronan."; /evidence="ECO:0000269|PubMed:15044457
uniprot
proteins
pubmed
12589770
uniprot
proteins
pubmed
15044457
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
29777959
uniprot
proteins
sequence_length
1243
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Photoreceptor outer segment membrane {ECO:0000269|PubMed:29777959}; Single-pass type I membrane protein {ECO:0000255}. Photoreceptor inner segment membrane {ECO:0000269|PubMed:29777959}; Single-pass type I membrane protein {ECO:0000255}. Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix {ECO:0000269|PubMed:29777959}.
uniprot
proteins
transmembrane_region
TRANSMEM 1107..1127; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins