TNFRSF21
entrez
27242
canonical
uniprot
O75509
canonical
ensembl
ENSG00000146072
resolver
ensp
ENSP00000296861
resolver
enst
ENST00000296861
resolver
genesymbol
TNFRSF21
resolver
genesymbol_syn
DR6
resolver
hgnc
HGNC:13469
resolver
uniprot
B2RDI9
resolver
uniprot
Q0D2P5
resolver
uniprot
Q96D86
resolver
uniprot_entry
TNR21_HUMAN
resolver
uniprot_sec
B2RDI9
resolver
uniprot_sec
Q0D2P5
resolver
uniprot_sec
Q96D86
resolver
amino_acid_sequence
MGTSPSSSTALASCSRIARRATATMIAGSLLLLGFLSTTTAQPEQKASNLIGTYRHVDRATGQVLTCDKCPAGTYVSEHCTNTSLRVCSSCPVGTFTRHENGIEKCHDCSQPCPWPMIEKLPCAALTDRECTCPPGMFQSNATCAPHTVCPVGWGVRKKGTETEDVRCKQCARGTFSDVPSSVMKCKAYTDCLSQNLVVIKPGTKETDNVCGTLPSFSSSTSPSPGTAIFPRPEHMETHEVPSSTYVPKGMNSTESNSSASVRPKVLSSIQEGTVPDNTSSARGKEDVNKTLPNLQVVNHQQGPHHRHILKLLPSMEATGGEKSSTPIKGPKRGHPRQNLHKHFDINEHLPWMIVLFLLLVLVVIVVCSIRKSSRTLKKGPRQDPSAIVEKAGLKKSMTPTQNREKWIYYCNGHGIDILKLVAAQVGSQWKDIYQFLCNASEREVAAFSNGYTADHERAYAALQHWTIRGPEASLAQLISALRQHRRNDVVEKIRGLMEDTTQLETDKLALPMSPSPLSPSPIPSPNAKLENSALLTVEPSPQDKNKGFFVDESEPLLRCDSTSSGSSALSRNGSFITKEKKDTVLRQVRLDPCDLQPIFDDMLHFLNPEELRVIEEIPQAEDKLDRLFEIIGVKSQEASQTLLDSVYSHLPDLL
uniprot
proteins
function
FUNCTION: Promotes apoptosis, possibly via a pathway that involves the activation of NF-kappa-B. Can also promote apoptosis mediated by BAX and by the release of cytochrome c from the mitochondria into the cytoplasm. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). Negatively regulates oligodendrocyte survival, maturation and myelination. Plays a role in signaling cascades triggered by stimulation of T-cell receptors, in the adaptive immune response and in the regulation of T-cell differentiation and proliferation. Negatively regulates T-cell responses and the release of cytokines such as IL4, IL5, IL10, IL13 and IFNG by Th2 cells. Negatively regulates the production of IgG, IgM and IgM in response to antigens. May inhibit the activation of JNK in response to T-cell stimulation. Also acts as a regulator of pyroptosis: recruits CASP8 in response to reactive oxygen species (ROS) and subsequent oxidation, leading to activation of GSDMC (PubMed:34012073). {ECO:0000269|PubMed:21725297, ECO:0000269|PubMed:22761420, ECO:0000269|PubMed:34012073, ECO:0000269|PubMed:9714541}.
uniprot
proteins
mass_dalton
71845
uniprot
proteins
mutagenesis
MUTAGEN 82; /note="N->Q: Abolishes one glycosylation site and reduces total N-glycosylation; when associated with Q-252; Q-278 and Q-289."; /evidence="ECO:0000269|PubMed:19654028"; MUTAGEN 141; /note="N->Q: Abolishes one glycosylation site and reduces total N-glycosylation; when associated with Q-82; Q-252; Q-278 and Q-289."; /evidence="ECO:0000269|PubMed:19654028"; MUTAGEN 252; /note="N->Q: Abolishes one glycosylation site and reduces total N-glycosylation; when associated with Q-278 and Q-289."; /evidence="ECO:0000269|PubMed:19654028"; MUTAGEN 257; /note="N->Q: Abolishes one glycosylation site and reduces total N-glycosylation; when associated with Q-82; Q-141; Q-252; Q-278 and Q-289."; /evidence="ECO:0000269|PubMed:19654028"; MUTAGEN 278; /note="N->Q: Abolishes one glycosylation site and reduces total N-glycosylation. Abolishes one glycosylation site and reduces total N-glycosylation; when associated with Q-82; Q-141; Q-252; Q-257 and Q-289."; /evidence="ECO:0000269|PubMed:19654028"; MUTAGEN 289; /note="N->Q: Abolishes one glycosylation site and reduces total N-glycosylation; when associated with Q-278."; /evidence="ECO:0000269|PubMed:19654028"; MUTAGEN 368; /note="C->V: Abolishes palmitoylation.
uniprot
proteins
post_translational_modification
PTM: Oxidized in response to reactive oxygen species (ROS), leading to endocytosis. {ECO:0000269|PubMed:34012073}.
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19654028
uniprot
proteins
pubmed
21463639
uniprot
proteins
pubmed
21725297
uniprot
proteins
pubmed
22525750
uniprot
proteins
pubmed
22761420
uniprot
proteins
pubmed
23559013
uniprot
proteins
pubmed
28743875
uniprot
proteins
pubmed
34012073
uniprot
proteins
pubmed
9714541
uniprot
proteins
sequence_length
655
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19654028}; Single-pass type I membrane protein {ECO:0000269|PubMed:19654028}. Note=Endocytosed following oxidation in response to reactive oxygen species (ROS). {ECO:0000269|PubMed:34012073}.
uniprot
proteins
transmembrane_region
TRANSMEM 350..370; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins