DDX23
entrez
9416
canonical
uniprot
Q9BUQ8
canonical
ensembl
ENSG00000174243
resolver
ensp
ENSP00000310723
resolver
genesymbol
DDX23
resolver
hgnc
HGNC:17347
resolver
uniprot
B2R600
resolver
uniprot
B3KY11
resolver
uniprot
B4DH15
resolver
uniprot
O43188
resolver
uniprot_entry
B3KY11_HUMAN
resolver
uniprot_entry
DDX23_HUMAN
resolver
uniprot_sec
B2R600
resolver
uniprot_sec
B4DH15
resolver
uniprot_sec
O43188
resolver
amino_acid_sequence
MAGELADKKDRDASPSKEERKRSRTPDRERDRDRDRKSSPSKDRKRHRSRDRRRGGSRSRSRSRSKSAERERRHKERERDKERDRNKKDRDRDKDGHRRDKDRKRSSLSPGRGKDFKSRKDRDSKKDEEDEHGDKKPKAQPLSLEELLAKKKAEEEAEAKPKFLSKAEREAEALKRRQQEVEERQRMLEEERKKRKQFQDLGRKMLEDPQERERRERRERMERETNGNEDEEGRQKIREEKDKSKELHAIKERYLGGIKKRRRTRHLNDRKFVFEWDASEDTSIDYNPLYKERHQVQLLGRGFIAGIDLKQQKREQSRFYGDLMEKRRTLEEKEQEEARLRKLRKKEAKQRWDDRHWSQKKLDEMTDRDWRIFREDYSITTKGGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQKPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSESEKRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKEDSAVFYELKQAILESPVSSCPPELANHPDAQHKPGTILTKKRREETIFA
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: Involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation (PubMed:18425142). Independently of its spliceosome formation function, required for the suppression of incorrect R-loops formed during transcription; R-loops are composed of a DNA:RNA hybrid and the associated non-template single-stranded DNA (PubMed:28076779). {ECO:0000269|PubMed:18425142, ECO:0000269|PubMed:28076779}.
uniprot
proteins
mass_dalton
95583
uniprot
proteins
post_translational_modification
PTM: In vitro phosphorylated by CLK1 and U1 snRNP-associated protein kinase (PubMed:9409622). Phosphorylated by SRPK2 and this phosphorylation is required for its association with the tri-snRNP (U4/U6-U5 tri-small nuclear ribonucleoproteins) and subsequent spliceosomal B complex formation (PubMed:18425142). May be phosphorylated by SRPK2 on Ser residues in the SR domain; the phosphorylation is required for the removal of inappropriate R-loops during transcription (PubMed:28076779). {ECO:0000269|PubMed:18425142, ECO:0000269|PubMed:28076779, ECO:0000269|PubMed:9409622}.
uniprot
proteins
protein_family
DDX23/PRP28 subfamily
uniprot
proteins
protein_family
DEAD box helicase family
uniprot
proteins
pubmed
11991638
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
16723661
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18425142
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20858735
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
26030138
uniprot
proteins
pubmed
28076779
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
9409622
uniprot
proteins
sequence_length
820
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:28076779, ECO:0000269|PubMed:9409622}. Chromosome {ECO:0000269|PubMed:28076779}. Note=During transcription, accumulates at chromatin loci where unscheduled R-loops form and colocalizes with paused 'Ser-5'-phosphorylated POLR2A/RNA polymerase II and kinase SRPK2. {ECO:0000269|PubMed:28076779}.
uniprot
proteins