Ggt5
entrez
23887
canonical
uniprot
Q9Z2A9
canonical
ensembl
ENSMUSG00000006344
resolver
ensp
ENSMUSP00000072074
resolver
ensp
ENSMUSP00000161313
resolver
genesymbol
Ggt5
resolver
genesymbol_syn
Ggtla1
resolver
uniprot
Q8C7B4
resolver
uniprot_entry
GGT5_MOUSE
resolver
uniprot_sec
Q8C7B4
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by serine-borate. {ECO:0000250|UniProtKB:P36269}.
uniprot
proteins
amino_acid_sequence
MAWGHRATVCLVLLGVGLGLVIVVLAAVLSPRQASCGPGAFTRAAVAADSKICSDIGRAILQQRGSPVDAAIAALVCTGVVNPQSMGLGGGVVFTIYNASTGKVEIINARETVPASYDQGLLNQCKNVLPLGTGAQWIGVPGELRGYAEAHRRHGRLPWAQLFQPTIALLREGFRVPFILSQFLNNSILRPHLSASTLRQLFFNGTETLRSQDPFPWPALANTLETVAKEGAEVLYTGRLGRMLVEDIAKQGSLLTVQDLAAFQPEVVEPLEMPLGNYTLYSPPPPAGGAILSFILNVLKGFNFSAETVARPGGEVNMYHHLVETLKFAVGQRWRLWDPSSHPGIQNISRDLLREDLAQRIRQQIDGRGDHHQLSHYNLTGVRGNRMGTSHVSVLGEDGSAVAATSTINTPFGAMVYSPRTGILLNNELLDLCWRHMPTSPITPPPVPGERPPSSMVPSILVNKGQGSKLVIGGAGGELIISAVAQTIMNKLWLGFDLTEAIASPILHVNSKGHVEYEPKFNQEVQKGLQDRGQIQSQSQRPVFLNAVQAVFQEGPCVYAASDLRKAGKASGY
uniprot
proteins
ec_number
2.3.2.2
uniprot
proteins
ec_number
3.4.19.13
uniprot
proteins
ec_number
3.4.19.14
uniprot
proteins
function
FUNCTION: Cleaves the gamma-glutamyl bond of extracellular glutathione tripeptide (gamma-Glu-Cys-Gly) and certain glutathione conjugates (PubMed:11463821, PubMed:12163373, PubMed:30842656, PubMed:9774450). Hydrolyzes glutathione releasing L-Glu and Cys-Gly dipeptide which is further metabolized to maintain extracellular cysteine levels but also to provide cysteine necessary for intracellular glutathione synthesis (By similarity). Among glutathione-S-conjugates metabolizes leukotriene C4 (LTC4) and S-geranylgeranyl-glutathione (GGG), but is inactive toward gamma-glutamyl leucine (PubMed:11463821, PubMed:12163373, PubMed:9774450). Converts extracellular LTC4 to LTD4 during acute inflammatory response (PubMed:11463821). Acts as a negative regulator of GGG bioactivity. GGT5 (via GGG catabolism) and ABCC1 (via extracellular transport) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to bone marrow parenchyma (PubMed:30842656, PubMed:34088745). The transpeptidation reaction, i.e. the transfer of gamma-glutamyl moiety to an acceptor molecule to yield a new gamma-glutamyl compound requires high concentration of dipeptide acceptor and is considered nonphysiological (By similarity). {ECO:0000250|UniProtKB:P36269, ECO:0000269|PubMed:11463821, ECO:0000269|PubMed:12163373, ECO:0000269|PubMed:30842656, ECO:0000269|PubMed:34088745, ECO:0000269|PubMed:9774450}.
uniprot
proteins
mass_dalton
61674
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; leukotriene D4 biosynthesis. {ECO:0000269|PubMed:11463821, ECO:0000269|PubMed:12163373, ECO:0000269|PubMed:9774450}.; PATHWAY: Sulfur metabolism; glutathione metabolism. {ECO:0000250|UniProtKB:P36269}.
uniprot
proteins
post_translational_modification
PTM: Cleaved by autocatalysis into a large and a small subunit. {ECO:0000250|UniProtKB:P19440}.; PTM: Glycosylated. {ECO:0000269|PubMed:12163373}.
uniprot
proteins
protein_family
Gamma-glutamyltransferase family
uniprot
proteins
pubmed
11463821
uniprot
proteins
pubmed
12163373
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30842656
uniprot
proteins
pubmed
34088745
uniprot
proteins
pubmed
9774450
uniprot
proteins
sequence_length
573
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:12163373}; Single-pass type II membrane protein {ECO:0000269|PubMed:12163373}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000269|PubMed:12163373
uniprot
proteins