LOX
entrez
4015
canonical
uniprot
P28300
canonical
ensembl
ENSG00000113083
resolver
ensp
ENSP00000231004
resolver
ensp
ENSP00000503104
resolver
ensp
ENSP00000503423
resolver
ensp
ENSP00000609146
resolver
enst
ENST00000231004
resolver
enst
ENST00000503759
resolver
enst
ENST00000513319
resolver
enst
ENST00000939087
resolver
genesymbol
LOX
resolver
hgnc
HGNC:6664
resolver
uniprot
A0A7I2V2U0
resolver
uniprot
A0A7I2V3H4
resolver
uniprot
B0AZT2
resolver
uniprot
B2R5Q3
resolver
uniprot
B7ZAJ4
resolver
uniprot
Q5FWF0
resolver
uniprot_entry
A0A7I2V2U0_HUMAN
resolver
uniprot_entry
A0A7I2V3H4_HUMAN
resolver
uniprot_entry
B0AZT2_HUMAN
resolver
uniprot_entry
B7ZAJ4_HUMAN
resolver
uniprot_entry
LYOX_HUMAN
resolver
uniprot_sec
B2R5Q3
resolver
uniprot_sec
Q5FWF0
resolver
amino_acid_sequence
MRFAWTVLLLGPLQLCALVHCAPPAAGQQQPPREPPAAPGAWRQQIQWENNGQVFSLLSLGSQYQPQRRRDPGAAVPGAANASAQQPRTPILLIRDNRTAAARTRTAGSSGVTAGRPRPTARHWFQAGYSTSRAREAGASRAENQTAPGEVPALSNLRPPSRVDGMVGDDPYNPYKYSDDNPYYNYYDTYERPRPGGRYRPGYGTGYFQYGLPDLVADPYYIQASTYVQKMSMYNLRCAAEENCLASTAYRADVRDYDHRVLLRFPQRVKNQGTSDFLPSRPRYSWEWHSCHQHYHSMDEFSHYDLLDANTQRRVAEGHKASFCLEDTSCDYGYHRRFACTAHTQGLSPGCYDTYGADIDCQWIDITDVKPGNYILKVSVNPSYLVPESDYTNNVVRCDIRYTGHHAYASGCTISPY
uniprot
proteins
disease_involvement
DISEASE: Aortic aneurysm, familial thoracic 10 (AAT10) [MIM:617168]: A form of thoracic aortic aneurysm, a disease characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. It is primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance. {ECO:0000269|PubMed:26838787, ECO:0000269|PubMed:27432961}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
1.4.3.13
uniprot
proteins
function
FUNCTION: Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:26838787). Regulator of Ras expression. May play a role in tumor suppression. Plays a role in the aortic wall architecture (By similarity). {ECO:0000250|UniProtKB:P28301, ECO:0000269|PubMed:26838787}.
uniprot
proteins
mass_dalton
46944
uniprot
proteins
mutagenesis
MUTAGEN 183..184; /note="YY->FF: Abolishes sulfation and reduces binding to collagen; when associated with 186-F-F-187 and F-190."; /evidence="ECO:0000269|PubMed:31152061"; MUTAGEN 186..187; /note="YY->FF: Abolishes sulfation and reduces binding to collagen; when associated with 183-F-F-184 and F-190."; /evidence="ECO:0000269|PubMed:31152061"; MUTAGEN 190; /note="Y->F: Abolishes sulfation and reduces binding to collagen; when associated with 183-F-F-184 and 186-F-F-187."; /evidence="ECO:0000269|PubMed:31152061
uniprot
proteins
post_translational_modification
PTM: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. {ECO:0000250|UniProtKB:P33072}.; PTM: Proteolytically cleaved by BMP1 which removes the propeptide (PubMed:31152061). Also proteolytically cleaved by ADAMTS2 and ADAMTS14, but not by ADAMTS3, at an additional cleavage site downstream of the BMP1 cleavage site (PubMed:31152061). The propeptide plays a role in directing the deposition of this enzyme to elastic fibers, via interaction with tropoelastin (By similarity). Cleavage by BMP1 to remove the propeptide does not increase enzymatic activity but increases binding to collagen (PubMed:31152061). Cleavage by ADAMTS2 produces a form with reduced collagen-binding activity (PubMed:31152061). {ECO:0000250|UniProtKB:P28301, ECO:0000269|PubMed:31152061}.; PTM: Sulfated at Tyr-187 and also at either Tyr-183 or Tyr-184 which enhances binding to collagen. {ECO:0000269|PubMed:31152061}.
uniprot
proteins
protein_family
Lysyl oxidase family
uniprot
proteins
pubmed
10391127
uniprot
proteins
pubmed
1352776
uniprot
proteins
pubmed
1357535
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1685472
uniprot
proteins
pubmed
19570982
uniprot
proteins
pubmed
19855011
uniprot
proteins
pubmed
26601954
uniprot
proteins
pubmed
26838787
uniprot
proteins
pubmed
27432961
uniprot
proteins
pubmed
31152061
uniprot
proteins
pubmed
7706256
uniprot
proteins
pubmed
7902322
uniprot
proteins
pubmed
8100215
uniprot
proteins
sequence_length
417
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:31152061}. Secreted, extracellular space.
uniprot
proteins