Sct
entrez
24769
canonical
uniprot
P11384
canonical
ensembl
ENSRNOG00000017873
resolver
ensembl
ENSRNOG00055002900
resolver
ensembl
ENSRNOG00055029333
resolver
ensembl
ENSRNOG00060033051
resolver
ensembl
ENSRNOG00065019290
resolver
ensp
ENSRNOP00000024094
resolver
ensp
ENSRNOP00055003351
resolver
ensp
ENSRNOP00055041882
resolver
ensp
ENSRNOP00060047389
resolver
ensp
ENSRNOP00065025919
resolver
enst
ENSRNOT00000024094
resolver
enst
ENSRNOT00055004527
resolver
enst
ENSRNOT00055050835
resolver
enst
ENSRNOT00060057332
resolver
enst
ENSRNOT00065032470
resolver
genesymbol
Sct
resolver
uniprot_entry
SECR_RAT
resolver
amino_acid_sequence
MEPLLPTPPLLLLLLLLLSSSFVLPAPPRTPRHSDGTFTSELSRLQDSARLQRLLQGLVGKRSEEDTENIPENSVARPKPLEDQLCLLWSNTQALQDWLLPRLSLDGSLSLWLPPGPRPAVDHSEWTETTRQPR
uniprot
proteins
function
FUNCTION: Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis (PubMed:19805236, PubMed:3047699, PubMed:7958688, PubMed:8568688, PubMed:9655680). Exerts its biological effects by binding to secretin receptor (SCTR), a G protein-coupled receptor expressed in the basolateral domain of several cells (PubMed:12403838, PubMed:9506976). Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content (PubMed:3047699, PubMed:7958688, PubMed:8568688, PubMed:9655680). Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (PubMed:3047699, PubMed:7958688, PubMed:8568688, PubMed:9655680). Production of bicarbonate is essential to neutralize the pH and ensure no damage is done to the small intestine by the gastric acid (By similarity). In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation (By similarity). Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation (By similarity). Also able to stimulate lipolysis in white adipocytes (By similarity). Also plays an important role in cellular osmoregulation: released into the systemic circulation in response to hyperosmolality and acts at different levels in the hypothalamus, pituitary and kidney to regulate water homeostasis (PubMed:19805236). Also plays a role in the central nervous system, possibly by acting as a neuropeptide hormone: required for hippocampal synaptic function and neural progenitor cells maintenance (By similarity). {ECO:0000250|UniProtKB:Q08535, ECO:0000269|PubMed:12403838, ECO:0000269|PubMed:19805236, ECO:0000269|PubMed:3047699, ECO:0000269|PubMed:7958688, ECO:0000269|PubMed:8568688, ECO:0000269|PubMed:9506976, ECO:0000269|PubMed:9655680}.
uniprot
proteins
mass_dalton
15072
uniprot
proteins
protein_family
Glucagon family
uniprot
proteins
pubmed
12403838
uniprot
proteins
pubmed
15276242
uniprot
proteins
pubmed
1711228
uniprot
proteins
pubmed
19805236
uniprot
proteins
pubmed
2061329
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2315322
uniprot
proteins
pubmed
2719704
uniprot
proteins
pubmed
3047699
uniprot
proteins
pubmed
7958688
uniprot
proteins
pubmed
8568688
uniprot
proteins
pubmed
9506976
uniprot
proteins
pubmed
9655680
uniprot
proteins
sequence_length
134
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19805236, ECO:0000269|PubMed:3047699}.
uniprot
proteins