Senp1
entrez
223870
canonical
uniprot
P59110
canonical
ensembl
ENSMUSG00000033075
resolver
ensp
ENSMUSP00000046598
resolver
ensp
ENSMUSP00000138056
resolver
ensp
ENSMUSP00000231444
resolver
ensp
ENSMUSP00000327808
resolver
enst
ENSMUST00000044189
resolver
enst
ENSMUST00000180657
resolver
genesymbol
Senp1
resolver
genesymbol_syn
Supr2
resolver
uniprot
M0QWX4
resolver
uniprot
Q8BTV5
resolver
uniprot
Q8BZF1
resolver
uniprot_entry
M0QWX4_MOUSE
resolver
uniprot_entry
SENP1_MOUSE
resolver
uniprot_sec
Q8BTV5
resolver
uniprot_sec
Q8BZF1
resolver
amino_acid_sequence
MDDTADGVKMDAGEVTLVNHGSTFRTHRPPQSGFPEEQLLLSDQQSLPFRQGTLDGSFTCSTRSPAYRPDYHSDNPSSDSFLGSGDVRTFGQSANGQWRNSTPASGSAPQKPRNSRSLCLETRKTSSGLSNTFVGKSNHHCHMSAYEKSFPIKPAPSPSWSGSCRRSLLSPKKTQRRHFSTAEETVQEEEKEIYRQLLQMVTGKQFCVAKPTTHFPLRLSRCLSSNKNSLKDSLLRNGNSCASHVIGSDTSSSGSASILTAQEQLSHSAHSLSSGTPDVAFGSKDSDPHHHLAAPHQPNSLPASNTQSEGSDSVILLKVKESQTPASSPTFFQAELWIKELTSVYDSRARERLRRIEEQKALALQLQNQRLQEQEHAVLDSVELHLRVPLEKEIPVTAAQETRKKSHQLTDSEDEFPEITEEMEKEIKNVFRNGNQDEVLSEAFRLTITRKDIQTLNHLNWLNDEIINFYMNMLMERSKEKGFPSVHAFNTFFFTKLKTAGYQAVKRWTKKVDVFSVDILLVPIHLGVHWCLAVVDFRRKSITYYDSMGGINNEACRILLQYLKQESVDKKRKEFDTNGWQLFSKKSQEIPQQMNGSDCGMFACKYADCITKDRPINFTQQHMPYFRKRMVWEILHRKLL
uniprot
proteins
ec_number
3.4.22.-
uniprot
proteins
function
FUNCTION: Protease that catalyzes two essential functions in the SUMO pathway (PubMed:15923632, PubMed:29499132). The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins (By similarity). The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein (By similarity). Deconjugates SUMO1 from HIPK2 (By similarity). Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity (By similarity). Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity (By similarity). Deconjugates SUMO2 from MTA1 (By similarity). Inhibits N(6)-methyladenosine (m6A) RNA methylation by mediating SUMO1 deconjugation from METTL3 and ALKBH5: METTL3 inhibits the m6A RNA methyltransferase activity, while ALKBH5 desumoylation promotes m6A demethylation (By similarity). Desumoylates CCAR2 which decreases its interaction with SIRT1 (By similarity). Deconjugates SUMO1 from GPS2 (PubMed:29499132). {ECO:0000250|UniProtKB:Q9P0U3, ECO:0000269|PubMed:15923632, ECO:0000269|PubMed:29499132}.
uniprot
proteins
mass_dalton
72511
uniprot
proteins
protein_family
Peptidase C48 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15923632
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
29499132
uniprot
proteins
sequence_length
640
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9P0U3}. Cytoplasm {ECO:0000250|UniProtKB:Q9P0U3}. Note=Shuttles between cytoplasm and nucleus. {ECO:0000250|UniProtKB:Q9P0U3}.
uniprot
proteins