Kcmf1
entrez
74287
canonical
uniprot
Q80UY2
canonical
ensembl
ENSMUSG00000055239
resolver
ensp
ENSMUSP00000064410
resolver
ensp
ENSMUSP00000144910
resolver
enst
ENSMUST00000204598
resolver
genesymbol
Kcmf1
resolver
genesymbol_syn
Debt91
resolver
uniprot
A0A0N4SV15
resolver
uniprot
Q9WUM2
resolver
uniprot_entry
A0A0N4SV15_MOUSE
resolver
uniprot_entry
KCMF1_MOUSE
resolver
uniprot_sec
Q9WUM2
resolver
amino_acid_sequence
MSRHEGVSCDACLKGNFRGRRYKCLICYDYDLCASCYESGATTTRHTTDHPMQCILTRVDFDLYYGGEAFSVEQPQSFTCPYCGKMGYTETSLQEHVTSEHAETSTEVICPICAALPGGDPNHVTDDFAAHLTLEHRAPRDLDESSGVRHVRRMFHPGRGLGGPRARRSNMHFTSSSTGGLSSSQSSYSPSSREAMDPIAELLSQLSGVRRSAGGQLNSSGPSASQLQQLQMQLQLERQHAQAARQQLETARNASRRTNTSSVTTTITQATATANTANTENSPQALHNSQFLLTRLNDPKMSEAERQSMESERADRSLFVQELLLSTLVREESSSSDEDDRGEMADFGAMGCVDIMPLDVALENLNLKESNKGNEPPPPPL
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and then transfers it to targeted substrates, promoting their degradation by the proteasome (By similarity). Together with UBR4, component of the N-end rule pathway: ubiquitinates proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their degradation (By similarity). Does not ubiquitinate proteins that are acetylated at the N-terminus (By similarity). Together with UBR4, part of a protein quality control pathway that catalyzes ubiquitination and degradation of proteins that have been oxidized in response to reactive oxygen species (ROS): recognizes proteins with an Arg-CysO3(H) degron at the N-terminus, and mediates assembly of heterotypic 'Lys-63'-/'Lys-27'-linked branched ubiquitin chains on oxidized proteins, leading to their degradation by autophagy (By similarity). Catalytic component of the silencing factor of the integrated stress response (SIFI) complex, a multiprotein complex that turns off the mitochondrial stress response after a specific stress event has been resolved (By similarity). The SIFI complex ubiquitinates and degrades (1) components of the HRI-mediated signaling of the integrated stress response, such as DELE1 and EIF2AK1/HRI, as well as (2) unimported mitochondrial precursors such as ABHD10 (By similarity). Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1 (By similarity). {ECO:0000250|UniProtKB:Q9P0J7}.
uniprot
proteins
mass_dalton
41791
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9P0J7}.
uniprot
proteins
protein_family
KCMF1 family
uniprot
proteins
pubmed
12810064
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
381
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9P0J7}. Late endosome {ECO:0000250|UniProtKB:Q9P0J7}. Lysosome {ECO:0000250|UniProtKB:Q9P0J7}.
uniprot
proteins