P2rx3
entrez
81739
canonical
uniprot
P49654
canonical
ensembl
ENSRNOG00000008552
resolver
ensp
ENSRNOP00000031629
resolver
ensp
ENSRNOP00000071698
resolver
ensp
ENSRNOP00000106307
resolver
enst
ENSRNOT00000077573
resolver
genesymbol
P2rx3
resolver
uniprot
A0A0G2K147
resolver
uniprot
Q9R1K3
resolver
uniprot_entry
A0A0G2K147_RAT
resolver
uniprot_entry
P2RX3_RAT
resolver
uniprot_entry
Q9R1K3_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Has high sensitivity to ATP. Fast activation by external ATP. Exhibits rapid desensitization. Sensitives to the ATP agonist:alpha/beta-methylene-ATP (PubMed:10440098). Subject to allosteric inhibition by AF-219. Mg(2+) and Ca(2+) slow deactivation of P2RX3 (By similarity). {ECO:0000250|UniProtKB:P56373, ECO:0000269|PubMed:10440098}.
uniprot
proteins
amino_acid_sequence
MNCISDFFTYETTKSVVVKSWTIGIINRAVQLLIISYFVGWVFLHEKAYQVRDTAIESSVVTKVKGFGRYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPENEEKYRCVSDSQCGPERFPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVEMPIMMEAENFTIFIKNSIRFPLFNFEKGNLLPNLTDKDIKRCRFHPEKAPFCPILRVGDVVKFAGQDFAKLARTGGVLGIKIGWVCDLDKAWDQCIPKYSFTRLDGVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKAFGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADHYKARKFEEVTETTLKGTASTNPVFASDQATVEKQSTDSGAYSIGH
uniprot
proteins
function
FUNCTION: Extracellular ATP-activated non-selective cation channel (PubMed:10440098, PubMed:7566119, PubMed:7566120). Plays particularly important role in sensory neurons where its activation is critical for gustatory, nociceptive responses, visceral reflexes and sensory hypersensitization (By similarity). {ECO:0000250|UniProtKB:Q3UR32, ECO:0000269|PubMed:10440098, ECO:0000269|PubMed:7566119, ECO:0000269|PubMed:7566120}.
uniprot
proteins
mass_dalton
44392
uniprot
proteins
protein_family
P2X receptor family
uniprot
proteins
pubmed
10440098
uniprot
proteins
pubmed
11181939
uniprot
proteins
pubmed
7566119
uniprot
proteins
pubmed
7566120
uniprot
proteins
pubmed
9721930
uniprot
proteins
sequence_length
397
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7566119, ECO:0000269|PubMed:7566120}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P56373}. Note=Localizes to neuronal cell body of sensory neurons. {ECO:0000269|PubMed:9721930}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..43; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P56373"; TRANSMEM 323..341; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P56373
uniprot
proteins