NEURL3
entrez
93082
canonical
uniprot
Q96EH8
canonical
ensembl
ENSG00000163121
resolver
ensp
ENSP00000478591
resolver
ensp
ENSP00000479456
resolver
ensp
ENSP00000480933
resolver
ensp
ENSP00000576009
resolver
enst
ENST00000310865
resolver
enst
ENST00000435380
resolver
enst
ENST00000451794
resolver
enst
ENST00000905950
resolver
genesymbol
NEURL3
resolver
genesymbol_syn
LINCR
resolver
hgnc
HGNC:25162
resolver
uniprot
A0A087WVI2
resolver
uniprot
A0A087WXE0
resolver
uniprot_entry
A0A087WVI2_HUMAN
resolver
uniprot_entry
A0A087WXE0_HUMAN
resolver
uniprot_entry
NEUL3_HUMAN
resolver
amino_acid_sequence
MGAQLCFEANAKAPREALRFHAEAKGAQVRLDTRGCIAHRRTTFHDGIVFSQRPVRLGERVALRVLREESGWCGGLRVGFTRLDPACVSVPSLPPFLCPDLEEQSPTWAAVLPEGCALTGDLVRFWVDRRGCLFAKVNAGCRLLLREGVPVGAPLWAVMDVYGTTKAIELLDPTASRLPTPMPWDLSNKAVPEPKATPGEECAICFYHAANTRLVPCGHTYFCRYCAWRVFSDTAKCPVCRWQIEAVAPAQGPPALRVEEGS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that plays a role in various biological processes such as lung development or innate immunity (PubMed:30111563). Seems to utilize UBE2E1. Promotes innate antiviral response by catalyzing 'Lys-63'-linked ubiquitination of IRF7 (PubMed:35792897). Also inhibits hepatitis C virus assembly by directly binding to viral E1 envelope glycoprotein to disrupt its interaction with E2 (PubMed:30111563). Plays an essential role in TLR4-mediated activation of MAPK pathways by promoting 'Lys-48'-linked polyubiquitination of the phosphatase DUSP1/MKP1 (PubMed:38667302). {ECO:0000269|PubMed:30111563, ECO:0000269|PubMed:35792897, ECO:0000269|PubMed:38667302}.
uniprot
proteins
mass_dalton
28789
uniprot
proteins
mutagenesis
MUTAGEN 202; /note="C->S: Complete loss of E3 ligase activity; when associated with S-205."; /evidence="ECO:0000269|PubMed:38667302"; MUTAGEN 205; /note="C->S: Complete loss of E3 ligase activity; when associated with S-202."; /evidence="ECO:0000269|PubMed:38667302
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:35792897}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
30111563
uniprot
proteins
pubmed
35792897
uniprot
proteins
pubmed
38667302
uniprot
proteins
sequence_length
262
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:30111563, ECO:0000269|PubMed:35792897}.
uniprot
proteins