NOL7
entrez
51406
canonical
uniprot
Q9UMY1
canonical
ensembl
ENSG00000225921
resolver
ensp
ENSP00000405674
resolver
ensp
ENSP00000535255
resolver
genesymbol
NOL7
resolver
genesymbol_syn
C6orf90
resolver
genesymbol_syn
NOP27
resolver
hgnc
HGNC:21040
resolver
uniprot
Q5T297
resolver
uniprot
Q9Y3U7
resolver
uniprot_entry
UTP16_HUMAN
resolver
uniprot_sec
Q5T297
resolver
uniprot_sec
Q9Y3U7
resolver
amino_acid_sequence
MVQLRPRASRAPASAEAMVDEGQLASEEEEAEHGLLLGQPSSGAAAEPLEEDEEGDDEFDDEAPEELTFASAQAEAREEERRVRETVRRDKTLLKEKRKRREELFIEQKKRKLLPDTILEKLTTASQTNIKKSPGKVKEVNLQKKNEDCEKGNDSKKVKVQKVQSVSQNKSYLAVRLKDQDLRDSRQQAAQAFIHNSLYGPGTNRTTVNKFLSLANKRLPVKRAAVQFLNNAWGIQKKQNAKRFKRRWMVRKMKTKK
uniprot
proteins
function
FUNCTION: Functions as part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit that coordinates the first two steps of ribosome biogenesis in transcription of the primary transcript pre-RNA and pre-18S processing (PubMed:34516797, PubMed:37246770). During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). This subunit is required for processing of the 5'-external transcribed spacer sequence (5'ETS) of the primary transcript pre-rRNA to yield the 18S rRNA (PubMed:37246770). Also plays a role in maintaining early pre-rRNA levels, either by assisting in its transcription or stability (PubMed:37246770). {ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:37246770}.
uniprot
proteins
mass_dalton
29426
uniprot
proteins
protein_family
UTP16 family
uniprot
proteins
pubmed
11790298
uniprot
proteins
pubmed
12429849
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16205646
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
34516797
uniprot
proteins
pubmed
37246770
uniprot
proteins
sequence_length
257
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:11790298, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:16205646, ECO:0000269|PubMed:34516797}.
uniprot
proteins