Casc3
entrez
259170
canonical
uniprot
Q8K3X0
canonical
ensembl
ENSRNOG00000009716
resolver
ensp
ENSRNOP00000013204
resolver
ensp
ENSRNOP00000099110
resolver
enst
ENSRNOT00000013204
resolver
genesymbol
Casc3
resolver
genesymbol_syn
Mln51
resolver
uniprot
G3V793
resolver
uniprot_entry
CASC3_RAT
resolver
uniprot_entry
G3V793_RAT
resolver
amino_acid_sequence
MADRRRQRASQDTEDEESGASGSDSGSPARGGGSCSGSAGGGGSGSLPSQRGGRGGGLHLRRVESGGAKSAEESECESEDGMEGDAVLSDYESAEDSEGEEEYSEEENSKVELKSEANDAADSSAKEKGEEKPESKGTVTGERQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSRQELIALYGYDIRSAHNPDDIKPRRIRKPRFGSPPQRDPNWIGDRSSKSHRHQGPGGNLPPRTFINRNAAGTGRMSTSRNYSRSGGFKEGRTSFRPVEVGGQHGARSGETLKHEANYRSRRLEQTPMRDPSPEPDAPLLGSPEKEEVASETPAAVPDITPPAPDRPIEKKSYSRARRTRTKVGDAVKAAEEVPPPSEGLTSAATVPESTPPAAKTGNWEAPVDSTTGGLEQDVAQLNIAEQNWSPGQPSFLQPRELRGMPNHIHMGAGPPPQFNRMEEMGVQSGRAKRYSSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGDSPAPLPPQGMIVQPEMHLPHPGLHPHQSPAPLPNPGLYPPPVSMSPGQPPPQQLLAPTYFSAPGVMNFGNPSYPYAPGALPPPPPPHLYPNTQAPSQVYGGVTYYNPAQQQVQPKPSPPRRTPQPVSIKPPPSEVVSRGSS
uniprot
proteins
function
FUNCTION: Required for pre-mRNA splicing as component of the spliceosome (By similarity). Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress response by participating in cytoplasmic stress granules assembly and by favoring cell recovery following stress. Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions. Binds poly(G) and poly(U) RNA homomer (By similarity). Component of the dendritic ribonucleoprotein particles (RNPs) in hippocampal neurons. May play a role in mRNA transport. {ECO:0000250|UniProtKB:O15234, ECO:0000269|PubMed:12843282}.
uniprot
proteins
mass_dalton
75904
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000269|PubMed:12843282}.; PTM: ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination (By similarity). {ECO:0000250}.; PTM: Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation. {ECO:0000250}.
uniprot
proteins
protein_family
CASC3 family
uniprot
proteins
pubmed
12843282
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
699
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12843282}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:12843282}. Nucleus {ECO:0000250|UniProtKB:Q8K3W3}. Nucleus speckle {ECO:0000250|UniProtKB:O15234}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:O15234}. Cell projection, dendrite {ECO:0000269|PubMed:12843282}. Note=Shuttles between the nucleus and the cytoplasm in a XPO1/CRM1-dependent manner (By similarity). Transported to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. In nuclear speckles, colocalizes with MAGOH. Under stress conditions, colocalizes with FMR1 and TIA1, but not MAGOH and RBM8A EJC core factors, in cytoplasmic stress granules (By similarity). In the dendrites of hippocampal neurons, localizes to dendritic ribonucleoprotein granules (Probable). {ECO:0000250|UniProtKB:O15234, ECO:0000250|UniProtKB:Q8K3W3, ECO:0000305|PubMed:12843282}.
uniprot
proteins