BACH1
entrez
571
canonical
uniprot
O14867
canonical
ensembl
ENSG00000156273
resolver
ensp
ENSP00000286800
resolver
ensp
ENSP00000382805
resolver
ensp
ENSP00000558505
resolver
ensp
ENSP00000558506
resolver
ensp
ENSP00000558509
resolver
ensp
ENSP00000597553
resolver
ensp
ENSP00000597554
resolver
ensp
ENSP00000597555
resolver
ensp
ENSP00000597556
resolver
ensp
ENSP00000597557
resolver
ensp
ENSP00000623505
resolver
enst
ENST00000286800
resolver
enst
ENST00000399921
resolver
enst
ENST00000888446
resolver
enst
ENST00000888447
resolver
enst
ENST00000888450
resolver
enst
ENST00000927494
resolver
enst
ENST00000927495
resolver
enst
ENST00000927496
resolver
enst
ENST00000927497
resolver
enst
ENST00000927498
resolver
enst
ENST00000953446
resolver
genesymbol
BACH1
resolver
hgnc
HGNC:935
resolver
uniprot
O43285
resolver
uniprot
Q6ICU0
resolver
uniprot_entry
BACH1_HUMAN
resolver
uniprot_sec
O43285
resolver
uniprot_sec
Q6ICU0
resolver
amino_acid_sequence
MSLSENSVFAYESSVHSTNVLLSLNDQRKKDVLCDVTIFVEGQRFRAHRSVLAACSSYFHSRIVGQADGELNITLPEEVTVKGFEPLIQFAYTAKLILSKENVDEVCKCVEFLSVHNIEESCFQFLKFKFLDSTADQQECPRKKCFSSHCQKTDLKLSLLDQRDLETDEVEEFLENKNVQTPQCKLRRYQGNAKASPPLQDSASQTYESMCLEKDAALALPSLCPKYRKFQKAFGTDRVRTGESSVKDIHASVQPNERSENECLGGVPECRDLQVMLKCDESKLAMEPEETKKDPASQCPTEKSEVTPFPHNSSIDPHGLYSLSLLHTYDQYGDLNFAGMQNTTVLTEKPLSGTDVQEKTFGESQDLPLKSDLGTREDSSVASSDRSSVEREVAEHLAKGFWSDICSTDTPCQMQLSPAVAKDGSEQISQKRSECPWLGIRISESPEPGQRTFTTLSSVNCPFISTLSTEGCSSNLEIGNDDYVSEPQQEPCPYACVISLGDDSETDTEGDSESCSAREQECEVKLPFNAQRIISLSRNDFQSLLKMHKLTPEQLDCIHDIRRRSKNRIAAQRCRKRKLDCIQNLESEIEKLQSEKESLLKERDHILSTLGETKQNLTGLCQKVCKEAALSQEQIQILAKYSAADCPLSFLISEKDKSTPDGELALPSIFSLSDRPPAVLPPCARGNSEPGYARGQESQQMSTATSEQAGPAEQCRQSGGISDFCQQMTDKCTTDE
uniprot
proteins
function
FUNCTION: Transcriptional regulator that acts as a repressor or activator, depending on the context. Binds to NF-E2 DNA binding sites. Plays important roles in coordinating transcription activation and repression by MAFK (By similarity). Together with MAF, represses the transcription of genes under the control of the NFE2L2 oxidative stress pathway (PubMed:24035498). {ECO:0000250|UniProtKB:P97302, ECO:0000269|PubMed:24035498, ECO:0000269|PubMed:39504958}.
uniprot
proteins
mass_dalton
81958
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the SCF(FBXL17) complex or by the by the SCF(FBXO22) complex, leading to its degradation by the proteasome. Under oxidative stress, reactive oxygen species covalently modify cysteine residues on the bZIP domain of BACH1 and release it from chromatin. If the BTB domain of BACH1 remains intact, its beta1-alpha6 degron is recognized by FBXO22, promoting its ubiquitination and degradation. If the structural integrity of the beta1-alpha6 degron is compromised, FBXL17 will transiently associate with the BACH1 BTB dimer and remodel it into stably bound monomer for ubiquitination and degradation (PubMed:39504958). {ECO:0000269|PubMed:24035498, ECO:0000269|PubMed:39504958}.
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
protein_family
CNC subfamily
uniprot
proteins
pubmed
10830953
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24035498
uniprot
proteins
pubmed
39504958
uniprot
proteins
pubmed
9479503
uniprot
proteins
pubmed
9544839
uniprot
proteins
sequence_length
736
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:24035498}.
uniprot
proteins