IL1RN
entrez
3557
canonical
uniprot
P18510
canonical
ensembl
ENSG00000136689
resolver
ensp
ENSP00000259206
resolver
ensp
ENSP00000329072
resolver
ensp
ENSP00000354816
resolver
ensp
ENSP00000387173
resolver
ensp
ENSP00000387210
resolver
ensp
ENSP00000512947
resolver
ensp
ENSP00000512949
resolver
genesymbol
IL1RN
resolver
genesymbol_syn
IL1F3
resolver
genesymbol_syn
IL1RA
resolver
hgnc
HGNC:6000
resolver
uniprot
A8K4G1
resolver
uniprot
Q14628
resolver
uniprot
Q53SC2
resolver
uniprot
Q7RTZ4
resolver
uniprot
Q96GD6
resolver
uniprot
Q9UPC0
resolver
uniprot_entry
IL1RA_HUMAN
resolver
uniprot_sec
A8K4G1
resolver
uniprot_sec
Q14628
resolver
uniprot_sec
Q53SC2
resolver
uniprot_sec
Q7RTZ4
resolver
uniprot_sec
Q96GD6
resolver
uniprot_sec
Q9UPC0
resolver
amino_acid_sequence
MEICRGLRSHLITLLLFLFHSETICRPSGRKSSKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE
uniprot
proteins
disease_involvement
DISEASE: Microvascular complications of diabetes 4 (MVCD4) [MIM:612628]: Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. {ECO:0000269|PubMed:8786086}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; DISEASE: Chronic recurrent multifocal osteomyelitis 2, with periostitis and pustulosis (CRMO2) [MIM:612852]: An autosomal recessive, autoinflammatory disease of skin and bone resulting in sterile multifocal osteomyelitis, periostitis, and pustulosis from birth. The term autoinflammatory disease describes a group of disorders characterized by attacks of seemingly unprovoked inflammation without significant levels of autoantibodies and autoreactive T-cells. {ECO:0000269|PubMed:19494218}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens. {ECO:0000250|UniProtKB:P25085, ECO:0000269|PubMed:7775431}.
uniprot
proteins
mass_dalton
20055
uniprot
proteins
protein_family
IL-1 family
uniprot
proteins
pubmed
11991722
uniprot
proteins
pubmed
1385987
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
1534997
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
1827201
uniprot
proteins
pubmed
1828896
uniprot
proteins
pubmed
18987736
uniprot
proteins
pubmed
19494218
uniprot
proteins
pubmed
2137200
uniprot
proteins
pubmed
2137201
uniprot
proteins
pubmed
2139180
uniprot
proteins
pubmed
2143761
uniprot
proteins
pubmed
32384874
uniprot
proteins
pubmed
7629520
uniprot
proteins
pubmed
7775431
uniprot
proteins
pubmed
7867645
uniprot
proteins
pubmed
7989776
uniprot
proteins
pubmed
8045306
uniprot
proteins
pubmed
8175703
uniprot
proteins
pubmed
8786086
uniprot
proteins
pubmed
8992991
uniprot
proteins
pubmed
9062194
uniprot
proteins
pubmed
9514884
uniprot
proteins
sequence_length
177
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Secreted {ECO:0000269|PubMed:32384874}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm.
uniprot
proteins