Tmem100
entrez
67888
canonical
uniprot
Q9CQG9
canonical
ensembl
ENSMUSG00000069763
resolver
ensp
ENSMUSP00000090464
resolver
ensp
ENSMUSP00000312427
resolver
ensp
ENSMUSP00000312429
resolver
enst
ENSMUST00000092788
resolver
genesymbol
Tmem100
resolver
uniprot_entry
TM100_MOUSE
resolver
amino_acid_sequence
MTEESTKENLGAPKSPTPVTMEKNPKREVVVTTGPLVSEVQLMAATGGAELSCYRCIIPFAVVVFITGIVVTAVAYSFNSHGSIISIFGLVLLSSGLFLLASSALCWKVRQRNKKVKRRESQTALVVNQRCLFA
uniprot
proteins
function
FUNCTION: Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10 (PubMed:22783020). Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons (PubMed:25640077). Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex (PubMed:25640077). {ECO:0000269|PubMed:22783020, ECO:0000269|PubMed:25640077}.
uniprot
proteins
mass_dalton
14504
uniprot
proteins
mutagenesis
MUTAGEN 117..119; /note="KRR->QQQ: Abolishes interaction with TRPA1. Increases interaction with TRPV1. Enhances interaction between TRPA1 and TRPV1."; /evidence="ECO:0000269|PubMed:25640077
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20848592
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22783020
uniprot
proteins
pubmed
23485812
uniprot
proteins
pubmed
25640077
uniprot
proteins
pubmed
31112734
uniprot
proteins
pubmed
34272044
uniprot
proteins
sequence_length
134
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23485812, ECO:0000269|PubMed:25640077}; Multi-pass membrane protein {ECO:0000269|PubMed:23485812, ECO:0000269|PubMed:25640077}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Perikaryon {ECO:0000269|PubMed:23485812}. Cytoplasm, perinuclear region {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Note=Colocalized with HSPA5 in the endoplasmic reticulum (ER). Enriched in ER microsome. Colocalized with BMP4 in neural cell bodies and neural fibers of the enteric nervous system (By similarity). {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 56..76; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 84..104; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins