IRX6
entrez
79190
canonical
uniprot
P78412
canonical
ensembl
ENSG00000159387
resolver
ensp
ENSP00000290552
resolver
ensp
ENSP00000539204
resolver
enst
ENST00000290552
resolver
genesymbol
IRX6
resolver
genesymbol_syn
IRX7
resolver
genesymbol_syn
IRXB3
resolver
hgnc
HGNC:14675
resolver
uniprot
B2RN06
resolver
uniprot
Q7Z2K0
resolver
uniprot_entry
IRX6_HUMAN
resolver
uniprot_sec
B2RN06
resolver
uniprot_sec
Q7Z2K0
resolver
amino_acid_sequence
MSFPHFGHPYRGASQFLASASSSTTCCESTQRSVSDVASGSTPAPALCCAPYDSRLLGSARPELGAALGIYGAPYAAAAAAQSYPGYLPYSPEPPSLYGALNPQYEFKEAAGSFTSSLAQPGAYYPYERTLGQYQYERYGAVELSGAGRRKNATRETTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPKNKGGEERKAEGGEEDSLGCLTADTKEVTASQEARGLRLSDLEDLEEEEEEEEEAEDEEVVATAGDRLTEFRKGAQSLPGPCAAAREGRLERRECGLAAPRFSFNDPSGSEEADFLSAETGSPRLTMHYPCLEKPRIWSLAHTATASAVEGAPPARPRPRSPECRMIPGQPPASARRLSVPRDSACDESSCIPKAFGNPKFALQGLPLNCAPCPRRSEPVVQCQYPSGAEAG
uniprot
proteins
function
FUNCTION: Transcription factor. Binds to the iroquois binding site (IBS) motif of target genes to regulate gene expression; functions as a transcriptional activator or repressor. Modulates expression of RCVRN, VSX1, BHLHE22/BHLHB5 and TACR3/Nk3r. Required downstream of retinal bipolar cell specification for the terminal differentiation of type 2, type 3a and possibly type 6 bipolar cells. {ECO:0000250|UniProtKB:Q9ER75}.
uniprot
proteins
mass_dalton
48240
uniprot
proteins
protein_family
TALE/IRO homeobox family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
446
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins