Ptprh
entrez
545902
canonical
uniprot
E9Q0N2
canonical
ensembl
ENSMUSG00000035429
resolver
ensp
ENSMUSP00000042396
resolver
ensp
ENSMUSP00000125833
resolver
ensp
ENSMUSP00000145543
resolver
enst
ENSMUST00000049113
resolver
enst
ENSMUST00000166650
resolver
enst
ENSMUST00000206999
resolver
genesymbol
Ptprh
resolver
genesymbol_syn
SAP-1
resolver
uniprot
B6ZDS3
resolver
uniprot
Q8BIW7
resolver
uniprot_entry
PTPRH_MOUSE
resolver
uniprot_sec
B6ZDS3
resolver
uniprot_sec
Q8BIW7
resolver
amino_acid_sequence
MARAGGNCGVWRSLVLLGLYGCSVVRAAGTSVTVDRHAPASSYEFSMWVEKDGVSSSPQIPVTTAAPNPVRNLRVEGQNNISISLSWEPPDQSSLQGLTYWTQCSRHGGQTETRNTTDTSVTVDGLDPGSSYECSVWVEKDGLYSKNETLNTSTAPNPVRNLRVEGQNNISISLSWEPPDQPSLQGLTYWAQCSRHGGQTETRNTADTSVTVDGLDPGSSYECSVWVEKDGVYSTNETLNTSTAPNPVRNLRVEGQNNISISLSWEPPDQPSLQGLTYWAQCSRHGGQTETRNTTDTSITVDGLDPGSSYECSVWVEKDGVYSTNETLSNTTAPNPVRNLRVKSQNNFSISLSWEPPDQPSLQGLIYWAQCSRHGGQTETRNTTDTSVTVDGLDPGFLYKCSVWVEKDGVYSTNETLNTSTVPISASNPVRNLRVEGQNNFSISLSWEPPDQSSLQGLTYWAQCSRHGGQTETRNTADTSVTVDGLDPGSSYECSVWVEKDGVYSTNETLNTSTVPAAVNITSCISTSGGYGVLLTWSCPSGGYESFEVKVGRKWRSENGSLCGKGVTVSDLEPAQSYTATVTTVFKDLKAQSLSTTCHTESAAIIAGAIVGILLLFILVGLLIVFLKRRRKKRQPKEVPKDLVCSCPGDILAKDFADHVRENEKDSNCGFAEEYQQLALEGQGQSQITASALENRSKNRYRNVLPYDWSRVPLQPLQEEPGSDYINASFMPGLWSPKEFIATQGPLPNTVGDFWRMVWEQQSHTLVMLTNCMESGRVKCEHYWPLDAQPCIHGQLQVMLISEEASENWTVRHLQLFHMKEQQTLSLRQFHYLAWPDHGVPYSPDPLLAFRKMLRQWMDQTTDGGPPIVHCSAGVGRTGTLIALDVLLRQLECEGLVGPFSFVKKMRESRPLMVQTEAQYVFLHQCILKSLQKPAPALVPEEAMYENVASLVYENASAIMAHESEFSASGC
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Protein phosphatase that may contribute to contact inhibition of cell growth and motility by mediating the dephosphorylation of focal adhesion-associated substrates and thus negatively regulating integrin-promoted signaling processes. Induces apoptotic cell death by at least two distinct mechanisms: inhibition of cell survival signaling mediated by PI 3-kinase, Akt, and ILK and activation of a caspase-dependent proapoptotic pathway. Inhibits the basal activity of LCK and its activation in response to TCR stimulation and TCR-induced activation of MAP kinase and surface expression of CD69. Inhibits TCR-induced tyrosine phosphorylation of LAT and ZAP70. Inhibits both basal activity of DOK1 and its CD2-induced tyrosine phosphorylation. Induces dephosphorylation of BCAR1, focal adhesion kinase and SRC. Reduces migratory activity of Jurkat cells (By similarity). Reduces tyrosine phosphorylation of CEACAM20 and thereby contributes to suppress the intestinal immune response (PubMed:26195794). {ECO:0000250|UniProtKB:Q9HD43, ECO:0000269|PubMed:26195794}.
uniprot
proteins
mass_dalton
106952
uniprot
proteins
mutagenesis
MUTAGEN 837; /note="D->A: Impairs phosphatase activity."; /evidence="ECO:0000269|PubMed:26195794"; MUTAGEN 871; /note="C->S: Impairs phosphatase activity."; /evidence="ECO:0000269|PubMed:26195794"; MUTAGEN 945; /note="Y->S: Reduces tyrosine phosphorylation. Abolishes tyrosine phosphorylation and interaction with GRB2 and FYN; when associated with A-953."; /evidence="ECO:0000269|PubMed:20398064"; MUTAGEN 953; /note="Y->A: Reduces tyrosine phosphorylation. Abolishes tyrosine phosphorylation and interaction with GRB2 and FYN; when associated with A-945."; /evidence="ECO:0000269|PubMed:20398064
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19170756
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20398064
uniprot
proteins
pubmed
26195794
uniprot
proteins
sequence_length
971
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, microvillus membrane {ECO:0000269|PubMed:19170756, ECO:0000269|PubMed:26195794}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000250|UniProtKB:Q9HD43}. Apical cell membrane {ECO:0000269|PubMed:19170756, ECO:0000269|PubMed:26195794}; Single-pass type I membrane protein {ECO:0000305}. Note=Colocalizes with CEACAM20 at the apical brush border of intestinal cells. {ECO:0000269|PubMed:26195794}.
uniprot
proteins
transmembrane_region
TRANSMEM 605..625; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins