Lypla2
entrez
26394
canonical
uniprot
Q9WTL7
canonical
ensembl
ENSMUSG00000028670
resolver
ensp
ENSMUSP00000064204
resolver
ensp
ENSMUSP00000101478
resolver
ensp
ENSMUSP00000248302
resolver
ensp
ENSMUSP00000248317
resolver
enst
ENSMUST00000067567
resolver
enst
ENSMUST00000105852
resolver
genesymbol
Lypla2
resolver
uniprot
Q3TJD6
resolver
uniprot_entry
LYPA2_MOUSE
resolver
uniprot_sec
Q3TJD6
resolver
amino_acid_sequence
MCGNTMSVPLLTDAATVSGAERETAAVIFLHGLGDTGHSWADALSTIRLPHVKYICPHAPRIPVTLNMKMVMPSWFDLMGLSPDAPEDEAGIKKAAENIKALIEHEMKNGIPANRIVLGGFSQGGALSLYTALTCPHPLAGIVALSCWLPLHRNFPQAANGSAKDLAILQCHGELDPMVPVRFGALTAEKLRTVVTPARVQFKTYPGVMHSSCPQEMAAVKEFLEKLLPPV
uniprot
proteins
ec_number
3.1.2.-
uniprot
proteins
ec_number
3.1.2.22
uniprot
proteins
function
FUNCTION: Acts as an acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GSDMD, GAP43, ZDHHC6 or HRAS (PubMed:38538834). Deacylates GAP43 (By similarity). Mediates depalmitoylation of ZDHHC6 (By similarity). Has lysophospholipase activity (PubMed:10064901). Hydrolyzes prostaglandin glycerol esters (PG-Gs) (PubMed:25301951). Hydrolyzes PG-Gs in the following order prostaglandin D2-glycerol ester (PGD2-G) > prostaglandin E2 glycerol ester (PGE2-G) > prostaglandin F2-alpha-glycerol ester (PGF2-alpha-G) (By similarity). Hydrolyzes 1-arachidonoylglycerol but not 2-arachidonoylglycerol or arachidonoylethanolamide (By similarity). {ECO:0000250|UniProtKB:O95372, ECO:0000269|PubMed:10064901, ECO:0000269|PubMed:38538834}.
uniprot
proteins
mass_dalton
24794
uniprot
proteins
protein_family
AB hydrolase 2 family
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
pubmed
10064901
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25301951
uniprot
proteins
pubmed
38538834
uniprot
proteins
sequence_length
231
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O95372}.
uniprot
proteins