Apoo
entrez
68316
canonical
uniprot
Q9DCZ4
canonical
ensembl
ENSMUSG00000079508
resolver
ensp
ENSMUSP00000109528
resolver
ensp
ENSMUSP00000109529
resolver
ensp
ENSMUSP00000109530
resolver
ensp
ENSMUSP00000109531
resolver
genesymbol
Apoo
resolver
genesymbol_syn
Fam121b
resolver
genesymbol_syn
Mic23
resolver
genesymbol_syn
Mic26
resolver
uniprot
B1ASQ2
resolver
uniprot
B1ASQ3
resolver
uniprot
Q9D186
resolver
uniprot_entry
MIC26_MOUSE
resolver
uniprot_sec
B1ASQ2
resolver
uniprot_sec
B1ASQ3
resolver
uniprot_sec
Q9D186
resolver
amino_acid_sequence
MFKVIQRSVGPASLSLLTFRVYAAPKKDSPHKSYMKIDELSLYSVPEGQSKYVEEPRTQLEENISQLRHHCEPYTSFCQEIYSHTKPKVDHFVQWGVDNYNYLQNAPPGFFPRLGVIGFAGFVGLLFARGSKIKKLVYPPFFMGLGASVYYPQQAITIAQITGEKLYDWGLRGYIVIEDLWKQNFQKPGNVKNSPGNK
uniprot
proteins
function
FUNCTION: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (By similarity). Can induce cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed:24743151). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (By similarity). {ECO:0000250|UniProtKB:Q9BUR5, ECO:0000269|PubMed:24743151}.
uniprot
proteins
mass_dalton
22604
uniprot
proteins
protein_family
Apolipoprotein O/MICOS complex subunit Mic27 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24743151
uniprot
proteins
sequence_length
198
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9BUR5}; Single-pass membrane protein {ECO:0000255}. Mitochondrion {ECO:0000269|PubMed:24743151}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9BUR5}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9BUR5}. Note=Exists in three distinct forms: a glycosylated and secreted form, an ER/Golgi-resident form and a non-glycosylated mitochondrial form. {ECO:0000250|UniProtKB:Q9BUR5}.
uniprot
proteins
transmembrane_region
TRANSMEM 108..128; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins