POLS
entrez
11044
canonical
uniprot
Q5XG87
canonical
ensembl
ENSG00000112941
resolver
ensp
ENSP00000230859
resolver
ensp
ENSP00000488642
resolver
ensp
ENSP00000602363
resolver
enst
ENST00000631941
resolver
genesymbol
POLS
resolver
genesymbol
TENT4A
resolver
genesymbol_syn
PAPD7
resolver
genesymbol_syn
POLS
resolver
genesymbol_syn
TRF4
resolver
hgnc
HGNC:16705
resolver
uniprot
A0A0X1KG68
resolver
uniprot
A0A9H4DBI9
resolver
uniprot
A8K1E2
resolver
uniprot
B7ZLL4
resolver
uniprot
M1JCE6
resolver
uniprot
O43289
resolver
uniprot
Q17RZ1
resolver
uniprot
Q9Y6C1
resolver
uniprot_entry
A0A9H4DBI9_HUMAN
resolver
uniprot_entry
B7ZLL4_HUMAN
resolver
uniprot_entry
PAPD7_HUMAN
resolver
uniprot_sec
A0A0X1KG68
resolver
uniprot_sec
A8K1E2
resolver
uniprot_sec
M1JCE6
resolver
uniprot_sec
O43289
resolver
uniprot_sec
Q17RZ1
resolver
uniprot_sec
Q9Y6C1
resolver
amino_acid_sequence
MDPRVAWIQPEQKGPANALWMQIWETSQGVGRGGSGFASYFCLNSPALDTAAAAGAAGRGSGGLGPALPAASPPPPGPTAPAALPPALLTALGPAAEGARRLHKSPSLSSSSSSSSSNAESGTESPGCSSSSSSSASLGRPGGGRGGAFFNFADGAPSAPGTANGHPGPRGPAPAGSPSQHQFHPGRRKRENKASTYGLNYLLSGSRAAALSGGGGPGAQAPRPGTPWKSRAYSPGIQGLHEEIIDFYNFMSPCPEEAAMRREVVKRIETVVKDLWPTADVQIFGSFSTGLYLPTSDIDLVVFGKWERPPLQLLEQALRKHNVAEPCSIKVLDKATVPIIKLTDQETEVKVDISFNMETGVRAAEFIKNYMKKYSLLPYLILVLKQFLLQRDLNEVFTGGISSYSLILMAISFLQLHPRIDARRADENLGMLLVEFFELYGRNFNYLKTGIRIKEGGAYIAKEEIMKAMTSGYRPSMLCIEDPLLPGNDVGRSSYGAMQVKQVFDYAYIVLSHAVSPLARSYPNRDAESTLGRIIKVTQEVIDYRRWIKEKWGSKAHPSPGMDSRIKIKERIATCNGEQTQNREPESPYGQRLTLSLSSPQLLSSGSSASSVSSLSGSDVDSDTPPCTTPSVYQFSLQAPAPLMAGLPTALPMPSGKPQPTTSRTLIMTTNNQTRFTIPPPTLGVAPVPCRQAGVEGTASLKAVHHMSSPAIPSASPNPLSSPHLYHKQHNGMKLSMKGSHGHTQGGGYSSVGSGGVRPPVGNRGHHQYNRTGWRRKKHTHTRDSLPVSLSR
uniprot
proteins
ec_number
2.7.7.-
uniprot
proteins
ec_number
2.7.7.19
uniprot
proteins
function
FUNCTION: Terminal nucleotidyltransferase that catalyzes preferentially the transfer of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation (PubMed:23376078, PubMed:30026317). Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation (PubMed:23376078). {ECO:0000269|PubMed:23376078, ECO:0000269|PubMed:30026317}.
uniprot
proteins
mass_dalton
84650
uniprot
proteins
mutagenesis
MUTAGEN 187..250; /note="Missing: Localizes to cytoplasm."; /evidence="ECO:0000269|PubMed:23376078
uniprot
proteins
protein_family
DNA polymerase type-B-like family
uniprot
proteins
pubmed
10066793
uniprot
proteins
pubmed
10926539
uniprot
proteins
pubmed
11459963
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18172165
uniprot
proteins
pubmed
22817747
uniprot
proteins
pubmed
23376078
uniprot
proteins
pubmed
30026317
uniprot
proteins
sequence_length
792
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23376078}. Nucleus, nucleoplasm {ECO:0000269|PubMed:23376078}. Note=Excluded from nucleolus, weak staining detected in the cytoplasm. {ECO:0000269|PubMed:23376078}.
uniprot
proteins