Rdx
entrez
19684
canonical
uniprot
P26043
canonical
ensembl
ENSMUSG00000032050
resolver
ensp
ENSMUSP00000000590
resolver
ensp
ENSMUSP00000055303
resolver
ensp
ENSMUSP00000128249
resolver
ensp
ENSMUSP00000158900
resolver
enst
ENSMUST00000000590
resolver
enst
ENSMUST00000061352
resolver
enst
ENSMUST00000163153
resolver
enst
ENSMUST00000238858
resolver
genesymbol
Rdx
resolver
uniprot
A0A5F8MPB9
resolver
uniprot
F7BTW5
resolver
uniprot
Q3TH46
resolver
uniprot
Q3TS85
resolver
uniprot
Q7TSG6
resolver
uniprot
Q9QW27
resolver
uniprot_entry
A0A5F8MPB9_MOUSE
resolver
uniprot_entry
F7BTW5_MOUSE
resolver
uniprot_entry
Q3TH46_MOUSE
resolver
uniprot_entry
Q7TSG6_MOUSE
resolver
uniprot_entry
RADI_MOUSE
resolver
uniprot_sec
Q3TS85
resolver
uniprot_sec
Q9QW27
resolver
activity_regulation
ACTIVITY REGULATION: A head-to-tail association, of the N-terminal and C-terminal halves results in a closed conformation (inactive form) which is incapable of actin or membrane-binding. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MPKPINVRVTTMDAELEFAIQPNTTGKQLFDQVVKTVGLREVWFFGLQYVDSKGYSTWLKLNKKVTQQDVKKENPLQFKFRAKFFPEDVSEELIQEITQRLFFLQVKEAILNDEIYCPPETAVLLASYAVQAKYGDYNKEIHKPGYLANDRLLPQRVLEQHKLTKEQWEERIQNWHEEHRGMLREDSMMEYLKIAQDLEMYGVNYFEIKNKKGTELWLGVDALGLNIYEHDDKLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQLERAQLENEKKKREIAEKEKERIEREKEELMERLRQIEEQTVKAQKELEEQTRKALELEQERQRAKEEAERLDRERRAAEEAKSAIAKQAADQMKNQEQLAAELAEFTAKIALLEEAKKKKEEEATEWQHKAFAAQEDLEKTKEELKTVMSAPPPPPPPPVIPPTENEHDEQDENSAEASAELSSEGVMNHRSEEERVTETQKNERVKKQLQALSSELAQARDETKKTQNDVLHAENVKAGRDKYKTLRQIRQGNTKQRIDEFEAM
uniprot
proteins
function
FUNCTION: Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane.
uniprot
proteins
mass_dalton
68543
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by tyrosine-protein kinases. Phosphorylation by ROCK2 suppresses the head-to-tail association of the N-terminal and C-terminal halves resulting in an opened conformation which is capable of actin and membrane-binding. {ECO:0000269|PubMed:8479753, ECO:0000269|PubMed:9456324}.
uniprot
proteins
pubmed
10970839
uniprot
proteins
pubmed
12522145
uniprot
proteins
pubmed
12554651
uniprot
proteins
pubmed
15913605
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16582480
uniprot
proteins
pubmed
16615918
uniprot
proteins
pubmed
17459884
uniprot
proteins
pubmed
18614175
uniprot
proteins
pubmed
1955455
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
24285636
uniprot
proteins
pubmed
30159668
uniprot
proteins
pubmed
8479753
uniprot
proteins
pubmed
9456324
uniprot
proteins
pubmed
9472040
uniprot
proteins
sequence_length
583
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Cell projection, microvillus {ECO:0000269|PubMed:24285636, ECO:0000269|PubMed:9472040}. Cell projection, stereocilium {ECO:0000269|PubMed:24285636, ECO:0000269|PubMed:30159668}. Note=Enriched at the stereocilium base with very low levels in the shaft of stereociliary bundles (PubMed:30159668). Highly concentrated in the undercoat of the cell-to-cell adherens junction and the cleavage furrow in the interphase and mitotic phase, respectively. {ECO:0000269|PubMed:30159668}.
uniprot
proteins