Rcn3
entrez
494125
canonical
uniprot
I6L9G5
canonical
ensembl
ENSRNOG00000043007
resolver
ensembl
ENSRNOG00055005658
resolver
ensembl
ENSRNOG00060008067
resolver
ensembl
ENSRNOG00065028698
resolver
ensp
ENSRNOP00000027917
resolver
ensp
ENSRNOP00055006960
resolver
ensp
ENSRNOP00060010154
resolver
ensp
ENSRNOP00065040650
resolver
enst
ENSRNOT00000027917
resolver
enst
ENSRNOT00055009117
resolver
enst
ENSRNOT00060013347
resolver
enst
ENSRNOT00065049527
resolver
genesymbol
Rcn3
resolver
uniprot_entry
RCN3_RAT
resolver
amino_acid_sequence
MMWRWTLMLLLLLLRHWALGKPSPDAGPHGQDRVHHGTPLSEAPHDDAHGNFQYDHEAFLGRDVAKEFDQLTPEESQARLGRIVDRMDLAGDSDGWVSLAELRAWIAHTQQRHIRDSVSAAWHTYDTDRDGRVGWEELRNATYGHYEPGEEFHDVEDAETYKKMLARDERRFRVADQDGDSMATREELTAFLHPEEFPHMRDIVVAETLEDLDKNKDGYVQVEEYIADLYSAEPGEEEPAWVQTERQQFRDFRDLNKDGRLDGSEVGYWVLPPSQDQPLVEANHLLHESDTDKDGRLSKAEILSNWNMFVGSQATNYGEDLTRHHDEL
uniprot
proteins
function
FUNCTION: Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (By similarity). Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3 (By similarity). By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (By similarity). Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens (By similarity). This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion (By similarity). {ECO:0000250|UniProtKB:Q8BH97, ECO:0000250|UniProtKB:Q96D15}.
uniprot
proteins
mass_dalton
37942
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:16433634}.; PTM: Degraded by PCSK6 and other endoproteases including FURIN and PCSK5. {ECO:0000250|UniProtKB:Q96D15}.
uniprot
proteins
protein_family
CREC family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16433634
uniprot
proteins
sequence_length
328
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:Q96D15}.
uniprot
proteins