CCT3
entrez
7203
canonical
uniprot
P49368
canonical
ensembl
ENSG00000163468
resolver
ensp
ENSP00000295688
resolver
ensp
ENSP00000357242
resolver
genesymbol
CCT3
resolver
genesymbol_syn
CCTG
resolver
genesymbol_syn
TRIC5
resolver
hgnc
HGNC:1616
resolver
uniprot
A6NE14
resolver
uniprot
B3KX11
resolver
uniprot
Q59H77
resolver
uniprot
Q5SZY1
resolver
uniprot
Q9BR64
resolver
uniprot_entry
B3KX11_HUMAN
resolver
uniprot_entry
Q59H77_HUMAN
resolver
uniprot_entry
TCPG_HUMAN
resolver
uniprot_sec
A6NE14
resolver
uniprot_sec
Q5SZY1
resolver
uniprot_sec
Q9BR64
resolver
amino_acid_sequence
MMGHRPVLVLSQNTKRESGRKVQSGNINAAKTIADIIRTCLGPKSMMKMLLDPMGGIVMTNDGNAILREIQVQHPAAKSMIEISRTQDEEVGDGTTSVIILAGEMLSVAEHFLEQQMHPTVVISAYRKALDDMISTLKKISIPVDISDSDMMLNIINSSITTKAISRWSSLACNIALDAVKMVQFEENGRKEIDIKKYARVEKIPGGIIEDSCVLRGVMINKDVTHPRMRRYIKNPRIVLLDSSLEYKKGESQTDIEITREEDFTRILQMEEEYIQQLCEDIIQLKPDVVITEKGISDLAQHYLMRANITAIRRVRKTDNNRIARACGARIVSRPEELREDDVGTGAGLLEIKKIGDEYFTFITDCKDPKACTILLRGASKEILSEVERNLQDAMQVCRNVLLDPQLVPGGGASEMAVAHALTEKSKAMTGVEQWPYRAVAQALEVIPRTLIQNCGASTIRLLTSLRAKHTQENCETWGVNGETGTLVDMKELGIWEPLAVKLQTYKTAVETAVLLLRIDDIVSGHKKKGDDQSRQGGAPDAGQE
uniprot
proteins
disease_involvement
DISEASE: Neurodevelopmental disorder with speech or visual impairment and brain hypomyelination (NEDSVH) [MIM:621034]: An autosomal dominant disorder characterized by global developmental delay, impaired intellectual development, poor or absent speech, and brain abnormalities including hypomyelination, cerebellar atrophy, and optic nerve atrophy. Some patients have severe visual impairment, dystonic movements, and seizures. {ECO:0000269|PubMed:39480921}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.6.1.-
uniprot
proteins
function
FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). {ECO:0000269|PubMed:20080638, ECO:0000269|PubMed:25467444, ECO:0000269|PubMed:35449234, ECO:0000269|PubMed:36493755, ECO:0000269|PubMed:37193829}.
uniprot
proteins
mass_dalton
60534
uniprot
proteins
protein_family
TCP-1 chaperonin family
uniprot
proteins
pubmed
14532270
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20080638
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25467444
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
33144677
uniprot
proteins
pubmed
35449234
uniprot
proteins
pubmed
36493755
uniprot
proteins
pubmed
37193829
uniprot
proteins
pubmed
39480921
uniprot
proteins
pubmed
8001976
uniprot
proteins
pubmed
8573069
uniprot
proteins
sequence_length
545
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
uniprot
proteins