MCAM
entrez
4162
canonical
uniprot
P43121
canonical
ensembl
ENSG00000076706
resolver
ensp
ENSP00000264036
resolver
ensp
ENSP00000526094
resolver
ensp
ENSP00000526095
resolver
ensp
ENSP00000685430
resolver
ensp
ENSP00000685432
resolver
genesymbol
MCAM
resolver
genesymbol_syn
MUC18
resolver
hgnc
HGNC:6934
resolver
uniprot
O95812
resolver
uniprot
Q59E86
resolver
uniprot
Q6PHR3
resolver
uniprot
Q6ZTR2
resolver
uniprot_entry
MUC18_HUMAN
resolver
uniprot_sec
O95812
resolver
uniprot_sec
Q59E86
resolver
uniprot_sec
Q6PHR3
resolver
uniprot_sec
Q6ZTR2
resolver
amino_acid_sequence
MGLPRLVCAFLLAACCCCPRVAGVPGEAEQPAPELVEVEVGSTALLKCGLSQSQGNLSHVDWFSVHKEKRTLIFRVRQGQGQSEPGEYEQRLSLQDRGATLALTQVTPQDERIFLCQGKRPRSQEYRIQLRVYKAPEEPNIQVNPLGIPVNSKEPEEVATCVGRNGYPIPQVIWYKNGRPLKEEKNRVHIQSSQTVESSGLYTLQSILKAQLVKEDKDAQFYCELNYRLPSGNHMKESREVTVPVFYPTEKVWLEVEPVGMLKEGDRVEIRCLADGNPPPHFSISKQNPSTREAEEETTNDNGVLVLEPARKEHSGRYECQGLDLDTMISLLSEPQELLVNYVSDVRVSPAAPERQEGSSLTLTCEAESSQDLEFQWLREETGQVLERGPVLQLHDLKREAGGGYRCVASVPSIPGLNRTQLVNVAIFGPPWMAFKERKVWVKENMVLNLSCEASGHPRPTISWNVNGTASEQDQDPQRVLSTLNVLVTPELLETGVECTASNDLGKNTSILFLELVNLTTLTPDSNTTTGLSTSTASPHTRANSTSTERKLPEPESRGVVIVAVIVCILVLAVLGAVLYFLYKKGKLPCRRSGKQEITLPPSRKSELVVEVKSDKLPEEMGLLQGSSGDKRAPGDQGEKYIDLRH
uniprot
proteins
function
FUNCTION: Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as a surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration. {ECO:0000269|PubMed:11036077, ECO:0000269|PubMed:8292890}.
uniprot
proteins
mass_dalton
71607
uniprot
proteins
pubmed
11036077
uniprot
proteins
pubmed
11709656
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2602381
uniprot
proteins
pubmed
8162602
uniprot
proteins
pubmed
8292890
uniprot
proteins
pubmed
8378324
uniprot
proteins
pubmed
8573133
uniprot
proteins
sequence_length
646
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 560..583; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins