EFCAB9
entrez
285588
canonical
uniprot
A8MZ26
canonical
ensembl
ENSG00000214360
resolver
ensp
ENSP00000381247
resolver
enst
ENST00000398186
resolver
genesymbol
EFCAB9
resolver
hgnc
HGNC:34530
resolver
uniprot_entry
EFCB9_HUMAN
resolver
amino_acid_sequence
MRLKQGSFLWYLYLDKIYCLLSVRNVKALAEYFHILDVHGKNTLNDVLFYHFLHHVTDLKKAQINIVFDMLDWNAVGEIDFEKFYMLVCMLLAHQNHLEGQFMYRHSRPVFDLLDLKGDLRIGAKNFEMYRFLFNIQKQELKDLFRDFDITGDNRLNYQEFKLYTIIYTDKLQKRQKTEEKEKGERKRSLYSKCHIK
uniprot
proteins
function
FUNCTION: Auxiliary component of the CatSper complex, a complex involved in sperm cell hyperactivation. pH-dependent Ca(2+) sensor required to activate the CatSper channel. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Associates with the CatSper complex via direct interaction with CATSPERZ, and senses intracellular Ca(2+). Together with CATSPERZ, associates with the CatSper channel pore and is required for the two-row structure of each single CatSper channel. {ECO:0000250|UniProtKB:Q9DAM2}.
uniprot
proteins
mass_dalton
23937
uniprot
proteins
pubmed
15372022
uniprot
proteins
sequence_length
197
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9DAM2}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9DAM2}. Note=Localizes to the principal piece of the sperm tail. {ECO:0000250|UniProtKB:Q9DAM2}.
uniprot
proteins