ILDR2
entrez
387597
canonical
uniprot
Q71H61
canonical
ensembl
ENSG00000143195
resolver
ensp
ENSP00000271417
resolver
ensp
ENSP00000432750
resolver
ensp
ENSP00000436120
resolver
ensp
ENSP00000436882
resolver
ensp
ENSP00000783374
resolver
enst
ENST00000271417
resolver
enst
ENST00000525740
resolver
enst
ENST00000528703
resolver
enst
ENST00000529071
resolver
genesymbol
ILDR2
resolver
genesymbol_syn
C1orf32
resolver
hgnc
HGNC:18131
resolver
uniprot
E9PNU3
resolver
uniprot
E9PQC8
resolver
uniprot
E9PR23
resolver
uniprot_entry
E9PNU3_HUMAN
resolver
uniprot_entry
E9PQC8_HUMAN
resolver
uniprot_entry
E9PR23_HUMAN
resolver
uniprot_entry
ILDR2_HUMAN
resolver
amino_acid_sequence
MDRVLLRWISLFWLTAMVEGLQVTVPDKKKVAMLFQPTVLRCHFSTSSHQPAVVQWKFKSYCQDRMGESLGMSSTRAQSLSKRNLEWDPYLDCLDSRRTVRVVASKQGSTVTLGDFYRGREITIVHDADLQIGKLMWGDSGLYYCIITTPDDLEGKNEDSVELLVLGRTGLLADLLPSFAVEIMPEWVFVGLVLLGVFLFFVLVGICWCQCCPHSCCCYVRCPCCPDSCCCPQALYEAGKAAKAGYPPSVSGVPGPYSIPSVPLGGAPSSGMLMDKPHPPPLAPSDSTGGSHSVRKGYRIQADKERDSMKVLYYVEKELAQFDPARRMRGRYNNTISELSSLHEEDSNFRQSFHQMRSKQFPVSGDLESNPDYWSGVMGGSSGASRGPSAMEYNKEDRESFRHSQPRSKSEMLSRKNFATGVPAVSMDELAAFADSYGQRPRRADGNSHEARGGSRFERSESRAHSGFYQDDSLEEYYGQRSRSREPLTDADRGWAFSPARRRPAEDAHLPRLVSRTPGTAPKYDHSYLGSARERQARPEGASRGGSLETPSKRSAQLGPRSASYYAWSPPGTYKAGSSQDDQEDASDDALPPYSELELTRGPSYRGRDLPYHSNSEKKRKKEPAKKTNDFPTRMSLVV
uniprot
proteins
function
FUNCTION: May be involved in ER stress pathways with effects on lipid homeostasis and insulin secretion. With ILDR1 and LSR, involved in the maintain of the epithelial barrier function through the recruitment of MARVELD2/tricellulin to tricellular tight junctions (By similarity). Also functions as a B7-like protein family member expressed on immune cells and inflamed tissue and with T-cell inhibitory activity (PubMed:29431694). In the inner ear, may regulate alternative pre-mRNA splicing via binding to TRA2A, TRA2B and SRSF1 (By similarity). {ECO:0000250|UniProtKB:B5TVM2, ECO:0000269|PubMed:29431694}.
uniprot
proteins
mass_dalton
71200
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
protein_family
LISCH7 family
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
29431694
uniprot
proteins
sequence_length
639
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:B5TVM2}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:B5TVM2}. Cell junction, tight junction {ECO:0000250|UniProtKB:B5TVM2}. Nucleus {ECO:0000250|UniProtKB:B5TVM2}.
uniprot
proteins
transmembrane_region
TRANSMEM 187..207; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins