RPAIN
entrez
84268
canonical
uniprot
Q86UA6
canonical
ensembl
ENSG00000129197
resolver
ensp
ENSP00000315069
resolver
ensp
ENSP00000370605
resolver
ensp
ENSP00000370606
resolver
ensp
ENSP00000385814
resolver
ensp
ENSP00000439939
resolver
ensp
ENSP00000446453
resolver
ensp
ENSP00000702055
resolver
genesymbol
RPAIN
resolver
genesymbol_syn
RIP
resolver
hgnc
HGNC:28641
resolver
uniprot
A0A0B4J1T3
resolver
uniprot
B3KTT3
resolver
uniprot
B4DI36
resolver
uniprot
B4DTX7
resolver
uniprot
E9PDG9
resolver
uniprot
E9PES3
resolver
uniprot
J3KNH8
resolver
uniprot
Q4G2Y0
resolver
uniprot
Q4G2Y5
resolver
uniprot
Q4G2Y8
resolver
uniprot
Q6B4V9
resolver
uniprot
Q6B4W0
resolver
uniprot
Q6B4W1
resolver
uniprot
Q6B4W4
resolver
uniprot
Q86X49
resolver
uniprot
Q9BT00
resolver
uniprot_entry
B3KTT3_HUMAN
resolver
uniprot_entry
RIP_HUMAN
resolver
uniprot_sec
A0A0B4J1T3
resolver
uniprot_sec
B4DI36
resolver
uniprot_sec
B4DTX7
resolver
uniprot_sec
E9PDG9
resolver
uniprot_sec
E9PES3
resolver
uniprot_sec
J3KNH8
resolver
uniprot_sec
Q4G2Y0
resolver
uniprot_sec
Q4G2Y5
resolver
uniprot_sec
Q4G2Y8
resolver
uniprot_sec
Q6B4V9
resolver
uniprot_sec
Q6B4W0
resolver
uniprot_sec
Q6B4W1
resolver
uniprot_sec
Q6B4W4
resolver
uniprot_sec
Q86X49
resolver
uniprot_sec
Q9BT00
resolver
amino_acid_sequence
MAESLRSPRRSLYKLVGSPPWKEAFRQRCLERMRNSRDRLLNRYRQAGSSGPGNSQNSFLVQEVMEEEWNALQSVENCPEDLAQLEELIDMAVLEEIQQELINQEQSIISEYEKSLQFDEKCLSIMLAEWEANPLICPVCTKYNLRITSGVVVCQCGLSIPSHSSELTEQKLRACLEGSINEHSAHCPHTPEFSVTGGTEEKSSLLMSCLACDTWAVIL
uniprot
proteins
function
FUNCTION: Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism. {ECO:0000269|PubMed:16135809}.
uniprot
proteins
mass_dalton
24770
uniprot
proteins
mutagenesis
MUTAGEN 114; /note="K->R: Abolishes sumoylation; when associated with R-121 and R-142."; /evidence="ECO:0000269|PubMed:16135809"; MUTAGEN 121; /note="K->R: Induces a strong decrease in sumoylation; when associated with N-103. Abolishes sumoylation; when associated with R-114 and R-142."; /evidence="ECO:0000269|PubMed:16135809"; MUTAGEN 142; /note="K->R: Abolishes sumoylation; when associated with R-114 and R-121."; /evidence="ECO:0000269|PubMed:16135809
uniprot
proteins
post_translational_modification
PTM: [Isoform 2]: Sumoylated. Sumoylation is required for localization in the nuclear PML body and transport of RPA complex in PML body. Upon UV irradiation and during S phase, it is desumoylated, releasing RPA complex that is translocated to sites of DNA damage. Sumoylation takes place at different Lys residues. Variant 'Lys-103' adds a sumoylation site and increases total sumoylation levels. {ECO:0000269|PubMed:16135809}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16008515
uniprot
proteins
pubmed
16135809
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
219
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus, PML body.
uniprot
proteins