Rab17
entrez
19329
canonical
uniprot
P35292
canonical
ensembl
ENSMUSG00000026304
resolver
ensp
ENSMUSP00000027529
resolver
ensp
ENSMUSP00000122178
resolver
enst
ENSMUST00000027529
resolver
enst
ENSMUST00000131428
resolver
genesymbol
Rab17
resolver
uniprot
Q0PD39
resolver
uniprot
Q921D2
resolver
uniprot
Q9D723
resolver
uniprot_entry
Q0PD39_MOUSE
resolver
uniprot_entry
RAB17_MOUSE
resolver
uniprot_sec
Q921D2
resolver
uniprot_sec
Q9D723
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MAQAAGLPQASTASGQPYVSKLVLLGSSSVGKTSLALRYMKQDFSNVLPTVGCAFFTKVLDLGSSSLKLEIWDTAGQEKYQSVCHLYFRGANAALLVYDITRKDSFHKAQQWLEDLEKEFQPGEVVVMLVGNKTDLGEEREVTFQEGKEFAESKSLLFMETSAKLNYQVSEIFNTVAQELLQRAGDTGSSRPQEGEAVALNQEPPIRQRQCCAR
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB17 is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates, for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface (PubMed:9624171). Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis (PubMed:9490718). Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (PubMed:21291502, PubMed:22291024). May also play a role in cell migration (By similarity). {ECO:0000250|UniProtKB:P20338, ECO:0000250|UniProtKB:Q9H0T7, ECO:0000269|PubMed:21291502, ECO:0000269|PubMed:22291024, ECO:0000269|PubMed:9490718, ECO:0000269|PubMed:9624171}.
uniprot
proteins
mass_dalton
23640
uniprot
proteins
mutagenesis
MUTAGEN 77; /note="Q->L: Probable constitutively active mutant unable to hydrolyze GTP; increases dendrite number and length."; /evidence="ECO:0000269|PubMed:22291024"; MUTAGEN 211..212; /note="CC->AA: Loss of association with membranes and redistribution to the cytosol."; /evidence="ECO:0000269|PubMed:9624171
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1555775
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21291502
uniprot
proteins
pubmed
22291024
uniprot
proteins
pubmed
8486736
uniprot
proteins
pubmed
9490718
uniprot
proteins
pubmed
9624171
uniprot
proteins
sequence_length
214
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000269|PubMed:21291502, ECO:0000269|PubMed:22291024, ECO:0000269|PubMed:9490718, ECO:0000269|PubMed:9624171}; Lipid-anchor {ECO:0000305|PubMed:9624171}; Cytoplasmic side {ECO:0000305|PubMed:9624171}. Melanosome {ECO:0000269|PubMed:21291502}. Cell projection, dendrite {ECO:0000269|PubMed:22291024}. Note=According to a report the protein is localized at the basolateral and apical plasma membrane of kidney epithelial cells (PubMed:8486736). It was later shown to localize to the apical recycling endosome in epithelial cells (PubMed:21291502). In neurons, localizes to the cell body and dendritic shaft and spine (PubMed:22291024). {ECO:0000269|PubMed:21291502, ECO:0000269|PubMed:22291024, ECO:0000269|PubMed:8486736}.
uniprot
proteins