Slc25a10
entrez
27376
canonical
uniprot
Q9QZD8
canonical
ensembl
ENSMUSG00000025792
resolver
ensp
ENSMUSP00000026899
resolver
enst
ENSMUST00000026899
resolver
genesymbol
Slc25a10
resolver
genesymbol_syn
Dic
resolver
uniprot
Q543J6
resolver
uniprot
Q99LJ9
resolver
uniprot
Q9D8G8
resolver
uniprot_entry
DIC_MOUSE
resolver
uniprot_sec
Q543J6
resolver
uniprot_sec
Q99LJ9
resolver
uniprot_sec
Q9D8G8
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by circadian protein CLOCK (Circadian Locomotor Output Cycles Kaput). {ECO:0000269|PubMed:30943427}.
uniprot
proteins
amino_acid_sequence
MAEARASRWYFGGLASCGAACCTHPLDLLKVHLQTQQEVKLRMTGMALQVVRTDGFLALYNGLSASLCRQMTYSLTRFAIYETMRDYMTKDSQGPLPFYNKVLLGGISGLTGGFVGTPADLVNVRMQNDMKLPPSQRRNYSHALDGLYRVAREESLRKLFSGATMASSRGALVTVGQLSCYDQAKQLVLSTGYLSDNIFTHFVSSFIAGGCATFLCQPLDVLKTRLMNSKGEYQGVFHCAMETAKLGPQAFFKGLFPAGIRLIPHTVLTFMFLEQLRKHFGIKVPTT
uniprot
proteins
function
FUNCTION: Catalyzes the electroneutral exchange or flux of physiologically important metabolites such as dicarboxylates (malonate, malate, succinate), inorganic sulfur-containing anions, and phosphate, across the mitochondrial inner membrane (PubMed:33746082). Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction (By similarity). Does not transport glutathione (By similarity). Plays an important role in gluconeogenesis, fatty acid metabolism, urea synthesis, and sulfur metabolism, particularly in liver, by supplying the substrates for the different metabolic processes (PubMed:16027120, PubMed:30943427, PubMed:33746082). Regulates fatty acid release from adipocytes, and contributes to systemic insulin sensitivity (PubMed:33746082). {ECO:0000250|UniProtKB:Q06143, ECO:0000250|UniProtKB:Q9UBX3, ECO:0000269|PubMed:16027120, ECO:0000269|PubMed:30943427, ECO:0000269|PubMed:33746082}.
uniprot
proteins
mass_dalton
31715
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
10567211
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16027120
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
30943427
uniprot
proteins
pubmed
33746082
uniprot
proteins
sequence_length
287
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:10567211}; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 62..81; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 102..122; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 162..181; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 202..222; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 254..274; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins