COPS8
entrez
10920
canonical
uniprot
Q99627
canonical
ensembl
ENSG00000198612
resolver
ensp
ENSP00000346340
resolver
ensp
ENSP00000375865
resolver
genesymbol
COPS8
resolver
genesymbol_syn
CSN8
resolver
hgnc
HGNC:24335
resolver
uniprot
A8K1H6
resolver
uniprot
Q53QS9
resolver
uniprot_entry
CSN8_HUMAN
resolver
uniprot_sec
A8K1H6
resolver
uniprot_sec
Q53QS9
resolver
amino_acid_sequence
MPVAVMAESAFSFKKLLDQCENQELEAPGGIATPPVYGQLLALYLLHNDMNNARYLWKRIPPAIKSANSELGGIWSVGQRIWQRDFPGIYTTINAHQWSETVQPIMEALRDATRRRAFALVSQAYTSIIADDFAAFVGLPVEEAVKGILEQGWQADSTTRMVLPRKPVAGALDVSFNKFIPLSEPAPVPPIPNEQQLARLTDYVAFLEN
uniprot
proteins
function
FUNCTION: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}.
uniprot
proteins
mass_dalton
23226
uniprot
proteins
protein_family
CSN8 family
uniprot
proteins
pubmed
11285227
uniprot
proteins
pubmed
11337588
uniprot
proteins
pubmed
12628923
uniprot
proteins
pubmed
12732143
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18850735
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26456823
uniprot
proteins
pubmed
7634324
uniprot
proteins
pubmed
9535219
uniprot
proteins
sequence_length
209
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:9535219}.
uniprot
proteins