Q62520
uniprot
Q62520
canonical
amino_acid_sequence
MLLDAGPQFPAIGVGSFARHHHHSAAAAAAAAAEMQDRELSLAAAQNGFVDSAAAHMGAFKLNPGAHELSPGQSSAFTSQGPGAYPGSAAAAAAAAALGPHAAHVGSYSGPPFNSTRDFLFRSRGFGDSAPGGGQHGLFGPGAGGLHHAHSDAQGHLLFPGLPPEQHGPHASQNVLNGQMRLGLPGEVFGRSEQYRQVASPRTDPYSAAQLHNQYGPMNMNMGMNMAAAAAHHHHHHHHPGAFFRYMRQQCIKQELICKWIDPEQLSNPKKSCNKTFSTMHELVTHVSVEHVGGPEQSNHVCFWEECPREGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFQCEFEGCDRRFANSSDRKKHMHVHTSDKPYLCKMCDKSYTHPSSLRKHMKVHESSPQGSESSPAASSGYESSTPPGLVSPSAEPQSSSNLSPAAAAAAAAAAAAAAAVSAVHRGAGSGSSGSGGGSAAGSGGGGGGAGGGGGGSSGGGSGTTGGHSGLSSNFNEWYV
uniprot
proteins
function
FUNCTION: Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos. {ECO:0000269|PubMed:10677508, ECO:0000269|PubMed:11053430, ECO:0000269|PubMed:11756505, ECO:0000269|PubMed:13678579, ECO:0000269|PubMed:15207726, ECO:0000269|PubMed:15465018, ECO:0000269|PubMed:18417618, ECO:0000269|PubMed:18524895, ECO:0000269|PubMed:20676059}.
uniprot
proteins
mass_dalton
54954
uniprot
proteins
mutagenesis
MUTAGEN 192; /note="S->A: Still phosphorylated."; /evidence="ECO:0000269|PubMed:18068128"; MUTAGEN 200; /note="S->A: Absence of phosphorylation. Inhibits interaction with DHX9. Does not affect DNA-binding affinity or subcellular localization. Inhibits strongly transcriptional activation."; /evidence="ECO:0000269|PubMed:18068128
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000269|PubMed:18068128}.; PTM: Ubiquitinated by RNF180, leading to its degradation. {ECO:0000250}.
uniprot
proteins
protein_family
GLI C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
10677508
uniprot
proteins
pubmed
11053430
uniprot
proteins
pubmed
11238441
uniprot
proteins
pubmed
11756505
uniprot
proteins
pubmed
13678579
uniprot
proteins
pubmed
15207726
uniprot
proteins
pubmed
15465018
uniprot
proteins
pubmed
18068128
uniprot
proteins
pubmed
18363970
uniprot
proteins
pubmed
18417618
uniprot
proteins
pubmed
18524895
uniprot
proteins
pubmed
20676059
uniprot
proteins
pubmed
8557628
uniprot
proteins
sequence_length
530
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Localizes in the cytoplasm in presence of MDFIC overexpression. Both phosphorylated and unphosphorylated forms are localized in the nucleus.
uniprot
proteins