Clk1
entrez
12747
canonical
uniprot
P22518
canonical
ensembl
ENSMUSG00000026034
resolver
ensp
ENSMUSP00000034868
resolver
genesymbol
Clk1
resolver
genesymbol_syn
Clk
resolver
genesymbol_syn
Sty
resolver
uniprot
A6H6K2
resolver
uniprot
Q3UXB6
resolver
uniprot_entry
CLK1_MOUSE
resolver
uniprot_sec
A6H6K2
resolver
uniprot_sec
Q3UXB6
resolver
activity_regulation
ACTIVITY REGULATION: Regulates splicing of its own pre-mRNA according to its kinase activity; increased expression of the catalytically active form influences splicing to generate the catalytically inactive splicing variant lacking the kinase domain. Leucettine L41 inhibits its kinase activity and affects the regulation of alternative splicing mediated by phosphorylation of SR proteins. {ECO:0000269|PubMed:21615147, ECO:0000269|PubMed:9315658}.
uniprot
proteins
amino_acid_sequence
MRHSKRTYCPDWDERDWDYGTWRSSSSHKRKKRSHSSAREQKRCRYDHSKTTDSYYLESRSINEKAYHSRRYVDEYRNDYMGYEPGHPYGEPGSRYQMHSSKSSGRSGRSSYKSKHRSRHHTSQHHSHGKSHRRKRSRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKVGGRRVAVKIVKNVDRYCEAAQSEIQVLEHLNTTDPHSTFRCVQMLEWFEHRGHICIVFELLGLSTYDFIKENSFLPFRMDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVKSDYTEAYNPKMKRDERTIVNPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSREHLAMMERILGPLPKHMIQKTRKRRYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDAEHELLFDLIGKMLEYDPAKRITLKEALKHPFFYPLKKHT
uniprot
proteins
ec_number
2.7.12.1
uniprot
proteins
function
FUNCTION: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates (PubMed:1825055, PubMed:1986248, PubMed:9307018). Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1 (PubMed:8617202, PubMed:9307018). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells (By similarity). {ECO:0000250|UniProtKB:P49759, ECO:0000269|PubMed:1825055, ECO:0000269|PubMed:1986248, ECO:0000269|PubMed:8617202, ECO:0000269|PubMed:9307018}.
uniprot
proteins
mass_dalton
57093
uniprot
proteins
mutagenesis
MUTAGEN 190; /note="K->R: Loss of kinase activity and changed localization in the nucleus."; /evidence="ECO:0000269|PubMed:1825055, ECO:0000269|PubMed:8617202
uniprot
proteins
post_translational_modification
PTM: Autophosphorylates on all three types of residues. {ECO:0000269|PubMed:9307018}.
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Lammer subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
1825055
uniprot
proteins
pubmed
1986248
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21615147
uniprot
proteins
pubmed
7665564
uniprot
proteins
pubmed
7990150
uniprot
proteins
pubmed
8617202
uniprot
proteins
pubmed
9307018
uniprot
proteins
pubmed
9315658
uniprot
proteins
sequence_length
483
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8617202, ECO:0000269|PubMed:9307018}.
uniprot
proteins