KCNK16
entrez
83795
canonical
uniprot
Q96T55
canonical
ensembl
ENSG00000095981
resolver
ensp
ENSP00000362324
resolver
ensp
ENSP00000362326
resolver
ensp
ENSP00000391498
resolver
ensp
ENSP00000415375
resolver
ensp
ENSP00000423842
resolver
enst
ENST00000507712
resolver
genesymbol
KCNK16
resolver
genesymbol_syn
TALK1
resolver
hgnc
HGNC:14464
resolver
uniprot
B5TJL9
resolver
uniprot
D6RC57
resolver
uniprot
Q2M2N9
resolver
uniprot
Q5TCF3
resolver
uniprot
Q6X6Z3
resolver
uniprot
Q6X6Z4
resolver
uniprot
Q6X6Z5
resolver
uniprot
Q9H591
resolver
uniprot_entry
D6RC57_HUMAN
resolver
uniprot_entry
KCNKG_HUMAN
resolver
uniprot_sec
B5TJL9
resolver
uniprot_sec
Q2M2N9
resolver
uniprot_sec
Q5TCF3
resolver
uniprot_sec
Q6X6Z3
resolver
uniprot_sec
Q6X6Z4
resolver
uniprot_sec
Q6X6Z5
resolver
uniprot_sec
Q9H591
resolver
activity_regulation
ACTIVITY REGULATION: The channel conductance is stimulated by extracellular alkaline pH. Inhibited by Ba(2+) ions, quinine, quinidine, chloroform and halothane. {ECO:0000269|PubMed:11263999, ECO:0000269|PubMed:12724142, ECO:0000269|PubMed:14985088, ECO:0000269|PubMed:36063992}.
uniprot
proteins
amino_acid_sequence
MPSAGLCSCWGGRVLPLLLAYVCYLLLGATIFQLLERQAEAQSRDQFQLEKLRFLENYTCLDQWAMEQFVQVIMEAWVKGVNPKGNSTNPSNWDFGSSFFFAGTVVTTIGYGNLAPSTEAGQVFCVFYALLGIPLNVIFLNHLGTGLRAHLAAIERWEDRPRRSQVLQVLGLALFLTLGTLVILIFPPMVFSHVEGWSFSEGFYFAFITLSTIGFGDYVVGTDPSKHYISVYRSLAAIWILLGLAWLALILPLGPLLLHRCCQLWLLSLRQGCGAKAAPGRRPRRGSTAARGVQVTPQDFPISKKGLGS
uniprot
proteins
function
FUNCTION: K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate (PubMed:11263999, PubMed:12724142, PubMed:14985088, PubMed:26919430, PubMed:28928238, PubMed:34032641, PubMed:36063992). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:36063992). In pancreatic islets, conducts K(+) countercurrents for Ca(2+) release from the endoplasmic reticulum (ER) and regulates the frequency and duration of cytosolic Ca(2+) oscillations coupled to secretion of pancreatic hormones (PubMed:26239056, PubMed:28928238, PubMed:29402588, PubMed:34032641). In pancreatic beta cells, drives ER Ca(2+) efflux, which in turn activates Ca(2+)-dependent plasma membrane K(+) slow currents and cytosolic Ca(2+) influx, overall contributing to synchronous cytosolic Ca(2+) oscillations. Limits glucose-induced cytosolic Ca(2+) oscillations coupled to second-phase INS secretion (PubMed:26239056, PubMed:28928238, PubMed:34032641). Contributes to beta cell adaptation to acute inflammation by maintaining normal cytosolic Ca(2+) levels and INS secretion (By similarity). May regulate beta cell mitochondrial Ca(2+) levels either indirectly via ER Ca(2+) efflux or directly by hyperpolarizing the mitochondrial membrane potential. Limits mitochondrial Ca(2+) oscillations and ATP production involved in glucose homeostasis upon metabolic stress (By similarity). In pancreatic delta cells, limits Ca(2+)-induced Ca(2+)-release involved in somatostatin secretion and modulates islet paracrine signaling involved in glucagon secretion (PubMed:29402588). Permeable to other monovalent cations such as Rb(+) and Cs(+) (By similarity) (PubMed:26919430). {ECO:0000250|UniProtKB:G5E845, ECO:0000250|UniProtKB:Q96T54, ECO:0000269|PubMed:11263999, ECO:0000269|PubMed:12724142, ECO:0000269|PubMed:14985088, ECO:0000269|PubMed:26239056, ECO:0000269|PubMed:26919430, ECO:0000269|PubMed:28928238, ECO:0000269|PubMed:29402588, ECO:0000269|PubMed:34032641, ECO:0000269|PubMed:36063992}.
uniprot
proteins
mass_dalton
34153
uniprot
proteins
mutagenesis
MUTAGEN 110; /note="G->E: Acts as a dominant negative when it assembles with wild-type KCNK16, KCNK17 and KCNK5 subunits, disrupting the channel K(+) selectivity filter and abolishing K(+) flux. Results in enhanced Ca(2+) levels in the ER stores."; /evidence="ECO:0000269|PubMed:26239056, ECO:0000269|PubMed:28928238, ECO:0000269|PubMed:36063992
uniprot
proteins
protein_family
Two pore domain potassium channel (TC 1.A.1.8) family
uniprot
proteins
pubmed
11263999
uniprot
proteins
pubmed
12724142
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14985088
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18516069
uniprot
proteins
pubmed
22158537
uniprot
proteins
pubmed
26239056
uniprot
proteins
pubmed
26919430
uniprot
proteins
pubmed
28928238
uniprot
proteins
pubmed
29348619
uniprot
proteins
pubmed
29402588
uniprot
proteins
pubmed
34032641
uniprot
proteins
pubmed
36063992
uniprot
proteins
pubmed
38206814
uniprot
proteins
sequence_length
309
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform a]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:28928238}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:26239056}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform b]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:28928238, ECO:0000305|PubMed:38206814}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion inner membrane {ECO:0000305|PubMed:38206814}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 14..34; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 120..140; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 166..186; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 238..258; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins