Dtx2
entrez
74198
canonical
uniprot
Q8R3P2
canonical
ensembl
ENSMUSG00000004947
resolver
ensp
ENSMUSP00000005072
resolver
ensp
ENSMUSP00000106772
resolver
ensp
ENSMUSP00000106774
resolver
ensp
ENSMUSP00000106775
resolver
ensp
ENSMUSP00000247906
resolver
ensp
ENSMUSP00000247908
resolver
ensp
ENSMUSP00000247915
resolver
ensp
ENSMUSP00000247916
resolver
ensp
ENSMUSP00000333035
resolver
ensp
ENSMUSP00000333036
resolver
enst
ENSMUST00000005072
resolver
genesymbol
Dtx2
resolver
uniprot
A0A0R4IZY1
resolver
uniprot
Q9CZV3
resolver
uniprot
Q9ER07
resolver
uniprot
Q9ER08
resolver
uniprot_entry
A0A0R4IZY1_MOUSE
resolver
uniprot_entry
DTX2_MOUSE
resolver
uniprot_sec
Q9CZV3
resolver
uniprot_sec
Q9ER07
resolver
uniprot_sec
Q9ER08
resolver
amino_acid_sequence
MAMAPSSSLPQVYPSHVVVAVWEWQDGLGIWHPYSATVCSFIEQHFVRQRGQHFGLGSLAHSIPLGQADPSLAPYIIDLPSWTQFRQNTGTMRSVRRHLFSQNSAPGQGIVWEWLGDDGSWVAYEARICDYLEQQVARGIQVVDLAPLGYNYTVNYATLTQTNKTSSFCRSVRRQVGPVYPVTSDIAVPRQMGLICFCQQCLHGSGTGPVSGRYRHSMTNLPAYPAPQAPHRTTTVSGAHQAFAPYNKPSLSGARSAPRLNTTNPWAAAPPVAGNQSLFHSSLSHLGPQLLPSGPSTSSGASASFPSGPSSSSPGSAPTTVPVQMPKASRVQQALAGMTSVLSAIGLPVCLSRAPRPTGPPASRPASKSHSSVKRLRKMSVKEGAPKPEPEQVIRKYTEELKVAPEEDCIICMEKLAVASGYSDMTDSKALGPMVVGRLTKCSHAFHLLCLLAMYCNGNKDGSLQCPSCKTIYGEKTGTQPWGKMEVFRFQMSLPGHEDCGTILIVYNIPHGIQGPEHPSPGKPFTARGFPRQCYLPDSPQGRKVLELLKVAWKRRLIFTVGTSSTTGETDTVVWNEIHHKTEMDRNVTGHGYPDPNYLQNVLAELAAQGVTEDCLEQQ
uniprot
proteins
disease_involvement
DISEASE: Note=Recurrent site of retroviral integration in murine B-cell lymphomas.
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase that conjugates ubiquitin to ADP-ribosylated cysteine residues, independently of lysine side chains or free N-termini. For example, PARP7 generates an ADP-ribosyl degron within the DNA-binding domain of the androgen receptor (AR), which is recognized by DTX2 and targeted for proteasomal degradation. Functions in genome stability maintenance by acting as an ADP-ribosylation-dependent regulator of DNA double-strand break repair. Mechanistically, recognizes PARylated substrates generated in response to DNA damage and promotes their ubiquitination via its RING and DTC domains. Also regulates additional cellular pathways through ubiquitination of specific substrates. Acts as an E3 ubiquitin ligase for RNA demethylase FTO, promoting its ubiquitination and proteasomal degradation. In turn, regulates antitumor immune responses. Promotes 'Lys-27'-linked ubiquitination of TFRC, thereby modulating iron metabolism and inhibiting ferroptosis (PubMed:41772062). In addition, promotes transcription of telomerase reverse transcriptase by mediating 'Lys-63'-linked ubiquitination of nuclear factor 1 C-type (NFIC) that stabilizes its binding on hTERT promoter. {ECO:0000250|UniProtKB:Q86UW9, ECO:0000269|PubMed:41772062}.
uniprot
proteins
mass_dalton
67195
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q86UW9}.
uniprot
proteins
protein_family
Deltex family
uniprot
proteins
pubmed
11226752
uniprot
proteins
pubmed
12185365
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
41772062
uniprot
proteins
sequence_length
619
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q86UW9}. Cytoplasm {ECO:0000250|UniProtKB:Q86UW9}. Nucleus {ECO:0000250|UniProtKB:Q86UW9}. Note=Predominantly cytoplasmic. Partially nuclear. Is recruited to DSBs in a PARylation-dependent manner. {ECO:0000250|UniProtKB:Q86UW9}.
uniprot
proteins