STMN2
entrez
11075
canonical
uniprot
Q93045
canonical
ensembl
ENSG00000104435
resolver
ensp
ENSP00000220876
resolver
ensp
ENSP00000429243
resolver
genesymbol
STMN2
resolver
genesymbol_syn
SCG10
resolver
genesymbol_syn
SCGN10
resolver
hgnc
HGNC:10577
resolver
uniprot
A8K9M2
resolver
uniprot
G3V110
resolver
uniprot
O14952
resolver
uniprot
Q6PK68
resolver
uniprot_entry
STMN2_HUMAN
resolver
uniprot_sec
A8K9M2
resolver
uniprot_sec
G3V110
resolver
uniprot_sec
O14952
resolver
uniprot_sec
Q6PK68
resolver
amino_acid_sequence
MAKTAMAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEERRKSQEAQVLKQLAEKREHEREVLQKALEENNNFSKMAEEKLILKMEQIKENREANLAAIIERLQEKERHAAEVRRNKELQVELSG
uniprot
proteins
function
FUNCTION: Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
20828
uniprot
proteins
post_translational_modification
PTM: Sumoylated. {ECO:0000269|PubMed:15561718}.; PTM: Phosphorylated mostly by MAPK8, but also by MAPK9 and MAPK10 in the developing brain cortex. {ECO:0000250}.; PTM: N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15. {ECO:0000269|PubMed:21471001}.
uniprot
proteins
protein_family
Stathmin family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15561718
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
18452648
uniprot
proteins
pubmed
20621975
uniprot
proteins
pubmed
21215777
uniprot
proteins
pubmed
21471001
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8622778
uniprot
proteins
sequence_length
179
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell projection, growth cone. Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, axon. Golgi apparatus. Endosome {ECO:0000250}. Cell projection, lamellipodium. Note=Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. SCG10 exists in both soluble and membrane-bound forms. Colocalized with CIB1 in neurites of developing hippocampal primary neurons (By similarity). Colocalized with CIB1 in the cell body, neuritis and growth cones of neurons. Colocalized with CIB1 to the leading edge of lamellipodia. {ECO:0000250}.
uniprot
proteins