TWSG1
entrez
57045
canonical
uniprot
Q9GZX9
canonical
ensembl
ENSG00000128791
resolver
ensp
ENSP00000262120
resolver
genesymbol
TWSG1
resolver
genesymbol_syn
TSG
resolver
hgnc
HGNC:12429
resolver
uniprot
B2RE08
resolver
uniprot
D3DUH9
resolver
uniprot
Q8NBI7
resolver
uniprot
Q96K46
resolver
uniprot_entry
TWSG1_HUMAN
resolver
uniprot_sec
B2RE08
resolver
uniprot_sec
D3DUH9
resolver
uniprot_sec
Q8NBI7
resolver
uniprot_sec
Q96K46
resolver
amino_acid_sequence
MKLHYVAVLTLAILMFLTWLPESLSCNKALCASDVSKCLIQELCQCRPGEGNCSCCKECMLCLGALWDECCDCVGMCNPRNYSDTPPTSKSTVEELHEPIPSLFRALTEGDTQLNWNIVSFPVAEELSHHENLVSFLETVNQPHHQNVSVPSNNVHAPYSSDKEHMCTVVYFDDCMSIHQCKISCESMGASKYRWFHNACCECIGPECIDYGSKTVKCMNCMF
uniprot
proteins
function
FUNCTION: May be involved in dorsoventral axis formation. Seems to antagonize BMP signaling by forming ternary complexes with CHRD and BMPs, thereby preventing BMPs from binding to their receptors. In addition to the anti-BMP function, also has pro-BMP activity, partly mediated by cleavage and degradation of CHRD, which releases BMPs from ternary complexes. May be an important modulator of BMP-regulated cartilage development and chondrocyte differentiation. May play a role in thymocyte development (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
25017
uniprot
proteins
protein_family
Twisted gastrulation protein family
uniprot
proteins
pubmed
11260715
uniprot
proteins
pubmed
11420619
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
16303743
uniprot
proteins
sequence_length
223
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
uniprot
proteins