IFNL3
entrez
282617
canonical
uniprot
Q8IZI9
canonical
ensembl
ENSG00000197110
resolver
ensembl
ENSG00000291876
resolver
ensp
ENSP00000409000
resolver
ensp
ENSP00000481633
resolver
ensp
ENSP00000517480
resolver
ensp
ENSP00000517481
resolver
enst
ENST00000413851
resolver
enst
ENST00000613087
resolver
enst
ENST00000709042
resolver
enst
ENST00000709043
resolver
genesymbol
IFNL3
resolver
genesymbol_syn
IL28B
resolver
genesymbol_syn
IL28C
resolver
genesymbol_syn
ZCYTO22
resolver
hgnc
HGNC:18365
resolver
uniprot
A0A0C4DGW8
resolver
uniprot
A2BDE1
resolver
uniprot
Q6VN56
resolver
uniprot
Q7Z4J3
resolver
uniprot
Q8IWL6
resolver
uniprot_entry
A0A0C4DGW8_HUMAN
resolver
uniprot_entry
IFNL3_HUMAN
resolver
uniprot_sec
A2BDE1
resolver
uniprot_sec
Q6VN56
resolver
uniprot_sec
Q7Z4J3
resolver
uniprot_sec
Q8IWL6
resolver
amino_acid_sequence
MTGDCMPVLVLMAAVLTVTGAVPVARLRGALPDARGCHIAQFKSLSPQELQAFKRAKDALEESLLLKDCKCRSRLFPRTWDLRQLQVRERPVALEAELALTLKVLEATADTDPALGDVLDQPLHTLHHILSQLRACIQPQPTAGPRTRGRLHHWLHRLQEAPKKESPGCLEASVTFNLFRLLTRDLNCVASGDLCV
uniprot
proteins
function
FUNCTION: Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression. {ECO:0000269|PubMed:12469119, ECO:0000269|PubMed:12483210}.
uniprot
proteins
mass_dalton
21706
uniprot
proteins
mutagenesis
MUTAGEN 57; /note="K->A: 51 fold decrease in antiviral activity."; /evidence="ECO:0000269|PubMed:19457860"; MUTAGEN 58; /note="D->A: 43 fold decrease in antiviral activity."; /evidence="ECO:0000269|PubMed:19457860"; MUTAGEN 118; /note="V->A: 68 fold decrease in antiviral activity."; /evidence="ECO:0000269|PubMed:19457860"; MUTAGEN 121; /note="Q->A: 46 fold decrease in antiviral activity."; /evidence="ECO:0000269|PubMed:19457860"; MUTAGEN 176; /note="F->A: 40 fold decrease in antiviral activity."; /evidence="ECO:0000269|PubMed:19457860"; MUTAGEN 179; /note="F->A: 650 fold decrease in antiviral activity."; /evidence="ECO:0000269|PubMed:19457860
uniprot
proteins
protein_family
Type-III (or lambda) interferon family
uniprot
proteins
pubmed
12469119
uniprot
proteins
pubmed
12483210
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16539846
uniprot
proteins
pubmed
19457860
uniprot
proteins
pubmed
20712453
uniprot
proteins
pubmed
24751921
uniprot
proteins
sequence_length
196
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12483210}.
uniprot
proteins