Pde3b
entrez
18576
canonical
uniprot
Q61409
canonical
ensembl
ENSMUSG00000030671
resolver
ensp
ENSMUSP00000032909
resolver
ensp
ENSMUSP00000221040
resolver
enst
ENSMUST00000032909
resolver
genesymbol
Pde3b
resolver
uniprot
E9QLQ3
resolver
uniprot
Q3UQ25
resolver
uniprot
Q8CIX5
resolver
uniprot
Q9Z1J9
resolver
uniprot_entry
E9QLQ3_MOUSE
resolver
uniprot_entry
PDE3B_MOUSE
resolver
uniprot_entry
Q3UQ25_MOUSE
resolver
uniprot_sec
Q8CIX5
resolver
uniprot_sec
Q9Z1J9
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by cGMP. {ECO:0000250|UniProtKB:Q63085}.
uniprot
proteins
amino_acid_sequence
MRKDERERDAPAMRSPPPPPASAASPPESLRNGYVKSCVSPLRQDPPRSFFFHLCRFCNVEPPAASLRAGARLSLGVLAAFVLAALLGARPERWAAAAAGLRTLLSACSLSLSPLFSIACAFFFLTCFLTRAQRGPGRGAGSWWLLALPACCYLGDFAAWQWWSWLRGEPAAAGRLCLVLSCVGLLTLAPRVRLRHGVLVLLFAGLVWWVSFSGLGALPPALRPLLSCLVGGAGCLLALGLDHFFHVRGASPPPRSASTAEEKVPVIRPRRRSSCVSLGESAAGYYGSGKMFRRPSLPCISREQMILWDWDLKQWCKPHYQNSGGGNGVDLSVLNEARNMVSDLLIDPSLPPQVISSLRSISSLMGAFSGSCRPKINSFTPFPGFYPCSEVEDPVEKGDRKLHKGLSGRTSFPTPQLRRSSGASSLLTNEHCSRWDRSSGKRSYQELSVSSHGCHLNGPFSSNLFTIPKQRSSSVSLTHHAGLRRAGALPSHSLLNSSSHVPVSAGSLTNRSPIGFPDTTDFLTKPNIILHRSLGSVSSAADFHQYLRNSDSNLCSSCGHQILKYVSTCEPDGTDHPSEKSGEEDSSVFSKEPLNIVETQEEETMKKACRELFLEGDSHLMEEAQQPNIDQEVSLDPMLVEDYDSLIEKMNNWNFQIFELVEKMGEKSGRILSQVMYTLFQDTGLLETFKIPTQEFMNYFRALENGYRDIPYHNRVHATDVLHAVWYLTTRPIPGLPQIHNNHETETKADSDGRLGSGQIAYISSKSCCIPDMSYGCLSSNIPALELMALYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLNLDHMEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSSENDRLLVCQVCIKLADINGPAKDRDLHLRWTEGIVNEFYEQGDEEAALGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWIETEEGDDTESDDDDDDDDGDGGEELDSDDEETEDNLNPKPQRRKGRRRIFCQLMHHLTENHKIWKEIIEEEEEKCKAEGNKLQVDNASLPQADEIQVIEEADEEEEQMFE
uniprot
proteins
ec_number
3.1.4.17
uniprot
proteins
function
FUNCTION: Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:10454575). Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling (By similarity). Controls cardiac contractility by reducing cAMP concentration in cardiocytes (PubMed:15294162). {ECO:0000250|UniProtKB:Q13370, ECO:0000269|PubMed:10454575, ECO:0000269|PubMed:15294162}.
uniprot
proteins
mass_dalton
122154
uniprot
proteins
mutagenesis
MUTAGEN 273; /note="S->A: Loss of insulin-induced phosphorylation."; /evidence="ECO:0000269|PubMed:10454575
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-273 mediates insulin-induced activation of PDE3B. {ECO:0000269|PubMed:10454575}.
uniprot
proteins
protein_family
Cyclic nucleotide phosphodiesterase family
uniprot
proteins
protein_family
PDE3 subfamily
uniprot
proteins
pubmed
10454575
uniprot
proteins
pubmed
15294162
uniprot
proteins
pubmed
16702214
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29768196
uniprot
proteins
pubmed
8921398
uniprot
proteins
sequence_length
1100
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:10454575}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 69..89; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 110..130; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 140..160; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 170..190; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 198..218; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 225..245; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins