Mag
entrez
29409
canonical
uniprot
P07722
canonical
ensembl
ENSRNOG00000021023
resolver
ensembl
ENSRNOG00055032453
resolver
ensembl
ENSRNOG00060032180
resolver
ensembl
ENSRNOG00065033423
resolver
ensp
ENSRNOP00000028544
resolver
ensp
ENSRNOP00000041373
resolver
enst
ENSRNOT00000044532
resolver
genesymbol
Mag
resolver
uniprot
A6JA35
resolver
uniprot
G3V9B3
resolver
uniprot
P02685
resolver
uniprot
P07723
resolver
uniprot_entry
A6JA35_RAT
resolver
uniprot_entry
G3V9B3_RAT
resolver
uniprot_entry
MAG_RAT
resolver
uniprot_sec
P02685
resolver
uniprot_sec
P07723
resolver
amino_acid_sequence
MIFLTTLPLFWIMISASRGGHWGAWMPSSISAFEGTCVSIPCRFDFPDELRPAVVHGVWYFNSPYPKNYPPVVFKSRTQVVHESFQGRSRLLGDLGLRNCTLLLSTLSPELGGKYYFRGDLGGYNQYTFSEHSVLDIINTPNIVVPPEVVAGTEVEVSCMVPDNCPELRPELSWLGHEGLGEPTVLGRLREDEGTWVQVSLLHFVPTREANGHRLGCQAAFPNTTLQFEGYASLDVKYPPVIVEMNSSVEAIEGSHVSLLCGADSNPPPLLTWMRDGMVLREAVAESLYLDLEEVTPAEDGIYACLAENAYGQDNRTVELSVMYAPWKPTVNGTVVAVEGETVSILCSTQSNPDPILTIFKEKQILATVIYESQLQLELPAVTPEDDGEYWCVAENQYGQRATAFNLSVEFAPIILLESHCAAARDTVQCLCVVKSNPEPSVAFELPSRNVTVNETEREFVYSERSGLLLTSILTLRGQAQAPPRVICTSRNLYGTQSLELPFQGAHRLMWAKIGPVGAVVAFAILIAIVCYITQTRRKKNVTESPSFSAGDNPHVLYSPEFRISGAPDKYESEKRLGSERRLLGLRGEPPELDLSYSHSDLGKRPTKDSYTLTEELAEYAEIRVK
uniprot
proteins
function
FUNCTION: Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2 (PubMed:8995428, PubMed:9298990). Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury; protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults; this probably depends on binding to gangliosides on the axon cell membrane (By similarity). Negative regulator of neurite outgrowth; in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides (PubMed:17640868). In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides (PubMed:17640868). In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides (PubMed:19367338). Inhibits axon longitudinal growth (PubMed:9298990). Inhibits axon outgrowth by binding to RTN4R (By similarity). Preferentially binds to alpha-2,3-linked sialic acid (PubMed:8995428). Binds ganglioside Gt1b (PubMed:8995428). {ECO:0000250|UniProtKB:P20917, ECO:0000269|PubMed:17640868, ECO:0000269|PubMed:19367338, ECO:0000269|PubMed:8995428, ECO:0000269|PubMed:9298990}.
uniprot
proteins
mass_dalton
69353
uniprot
proteins
mutagenesis
MUTAGEN 118; /note="R->A,D: Abolishes inhibition of neurite outgrowth from CNS neurons."; /evidence="ECO:0000269|PubMed:9298990"; MUTAGEN 118; /note="R->A: No effect on inhibition of neurite outgrowth from sensory neurons."; /evidence="ECO:0000269|PubMed:19367338
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:P20916}.; PTM: Phosphorylated on tyrosine residues. {ECO:0000269|PubMed:16998591}.; PTM: Ubiquitinated, leading to proteasomal degradation. {ECO:0000250|UniProtKB:P20917}.
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
protein_family
SIGLEC (sialic acid binding Ig-like lectin) family
uniprot
proteins
pubmed
16998591
uniprot
proteins
pubmed
1703542
uniprot
proteins
pubmed
17640868
uniprot
proteins
pubmed
19158290
uniprot
proteins
pubmed
19367338
uniprot
proteins
pubmed
19420245
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2432614
uniprot
proteins
pubmed
2435742
uniprot
proteins
pubmed
2438699
uniprot
proteins
pubmed
4020419
uniprot
proteins
pubmed
6347394
uniprot
proteins
pubmed
6586369
uniprot
proteins
pubmed
8995428
uniprot
proteins
pubmed
9298990
uniprot
proteins
sequence_length
626
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16998591, ECO:0000269|PubMed:19367338, ECO:0000269|PubMed:8995428, ECO:0000269|PubMed:9298990}; Single-pass type I membrane protein {ECO:0000269|PubMed:16998591, ECO:0000269|PubMed:19367338, ECO:0000269|PubMed:9298990}. Membrane raft {ECO:0000269|PubMed:16998591}.
uniprot
proteins
transmembrane_region
TRANSMEM 517..536; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins