Nedd8
entrez
25490
canonical
uniprot
Q71UE8
canonical
ensembl
ENSRNOG00000019895
resolver
ensembl
ENSRNOG00055012620
resolver
ensembl
ENSRNOG00060023791
resolver
ensembl
ENSRNOG00065033388
resolver
ensp
ENSRNOP00000061284
resolver
ensp
ENSRNOP00055017443
resolver
ensp
ENSRNOP00060034170
resolver
ensp
ENSRNOP00065047244
resolver
enst
ENSRNOT00000064916
resolver
enst
ENSRNOT00055021529
resolver
enst
ENSRNOT00060041254
resolver
enst
ENSRNOT00065057403
resolver
genesymbol
Nedd8
resolver
uniprot_entry
NEDD8_RAT
resolver
amino_acid_sequence
MLIKVKTLTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQQRLIYSGKQMNDEKTAADYKILGGSVLHLVLALRGGGGLGQ
uniprot
proteins
function
FUNCTION: Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis via its conjugation to a limited number of cellular proteins, such as cullins or p53/TP53. Attachment of NEDD8 to cullins is critical for the recruitment of E2 to the cullin-RING-based E3 ubiquitin-protein ligase complex, thus facilitating polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. Attachment of NEDD8 to p53/TP53 inhibits p53/TP53 transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Neddylates EGFR resulting in protein stabilization and translocation to the cell membrane (By similarity). {ECO:0000250|UniProtKB:Q15843}.
uniprot
proteins
mass_dalton
8972
uniprot
proteins
post_translational_modification
PTM: Cleavage of precursor form by UCHL3 or SENP8 is necessary for function. {ECO:0000250|UniProtKB:Q15843}.
uniprot
proteins
protein_family
Ubiquitin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21808025
uniprot
proteins
sequence_length
81
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q15843}. Note=Mainly nuclear. {ECO:0000250|UniProtKB:Q15843}.
uniprot
proteins