PDK4
entrez
5166
canonical
uniprot
Q16654
canonical
ensembl
ENSG00000004799
resolver
ensp
ENSP00000005178
resolver
ensp
ENSP00000556108
resolver
enst
ENST00000005178
resolver
enst
ENST00000886049
resolver
genesymbol
PDK4
resolver
genesymbol_syn
PDHK4
resolver
hgnc
HGNC:8812
resolver
uniprot
A4D1H4
resolver
uniprot_entry
A4D1H4_HUMAN
resolver
uniprot_entry
PDK4_HUMAN
resolver
amino_acid_sequence
MKAARFVLRSAGSLNGAGLVPREVEHFSRYSPSPLSMKQLLDFGSENACERTSFAFLRQELPVRLANILKEIDILPTQLVNTSSVQLVKSWYIQSLMDLVEFHEKSPDDQKALSDFVDTLIKVRNRHHNVVPTMAQGIIEYKDACTVDPVTNQNLQYFLDRFYMNRISTRMLMNQHILIFSDSQTGNPSHIGSIDPNCDVVAVVQDAFECSRMLCDQYYLSSPELKLTQVNGKFPDQPIHIVYVPSHLHHMLFELFKNAMRATVEHQENQPSLTPIEVIVVLGKEDLTIKISDRGGGVPLRIIDRLFSYTYSTAPTPVMDNSRNAPLAGFGYGLPISRLYAKYFQGDLNLYSLSGYGTDAIIYLKALSSESIEKLPVFNKSAFKHYQMSSEADDWCIPSREPKNLAKEVAM
uniprot
proteins
ec_number
2.7.11.2
uniprot
proteins
function
FUNCTION: Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism. {ECO:0000269|PubMed:15955060, ECO:0000269|PubMed:18658136, ECO:0000269|PubMed:21816445, ECO:0000269|PubMed:21852536}.
uniprot
proteins
mass_dalton
46469
uniprot
proteins
mutagenesis
MUTAGEN 157; /note="Y->F: Loss of activity."; /evidence="ECO:0000269|PubMed:18658136"; MUTAGEN 161; /note="R->A: Loss of activity."; /evidence="ECO:0000269|PubMed:18658136"; MUTAGEN 394; /note="D->A: Loss of activity; when associated with A-395."; /evidence="ECO:0000269|PubMed:18658136"; MUTAGEN 395; /note="W->A: Loss of activity; when associated with A-394."; /evidence="ECO:0000269|PubMed:18658136
uniprot
proteins
protein_family
PDK/BCKDK protein kinase family
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14966024
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15955060
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17669420
uniprot
proteins
pubmed
18658136
uniprot
proteins
pubmed
20715114
uniprot
proteins
pubmed
21816445
uniprot
proteins
pubmed
21852536
uniprot
proteins
pubmed
21904029
uniprot
proteins
pubmed
8798399
uniprot
proteins
sequence_length
411
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix.
uniprot
proteins