Msl2
entrez
77853
canonical
uniprot
Q69ZF8
canonical
ensembl
ENSMUSG00000066415
resolver
ensp
ENSMUSP00000082270
resolver
enst
ENSMUST00000085177
resolver
genesymbol
Msl2
resolver
genesymbol_syn
Kiaa1585
resolver
genesymbol_syn
Msl2l1
resolver
genesymbol_syn
Rnf184
resolver
uniprot
Q497U7
resolver
uniprot
Q8CBI7
resolver
uniprot_entry
MSL2_MOUSE
resolver
uniprot_sec
Q497U7
resolver
uniprot_sec
Q8CBI7
resolver
amino_acid_sequence
MNPVNATALYISASRLVLNYDPGDPKAFTEINRLLPYFRQSLSCCVCGHLLQDPIAPTNSTCQHYVCKTCKGKKMMMKPSCSWCKDYEQFEENKQLSILVNCYKKLCEYITQTTLARDIIEAVDCSSDILALLNDGSLFCEETEKPSDSSFTLCLTHSPLPSTSEPTADPQASLSPMSESTLSIAIGSSVINGLPTYNGLSIDRFGINIPSPEHPNTIDVCNTVDIKTEDLSDNLPPVCDTVATDLCSTGIDICSFSEDIKPGDSLLLSVEEVLRSLETVSNTEVCCPNLQPNLEATVSNGPFLQLSSQSLSHNVFMSTSPALHGLSCTAATPKVAKLNRKRSRSESDSEKVQPLPISTIIRGPTLGASAPVTVKRESKISLQPIATVPNGGTTPKISKTVLLSTKSMKKSHEHGSKKSHSKSKPGILKKDKAVKEKMPSHHFMPGSPTKTVYKKPQEKKGCKCGRATQNPSVLTCRGQRCPCYSNRKACLDCICRGCQNSYMANGEKKLEAFAVPEKALEQTRLTLGINVTSIAVRNASTSTSVINVTGSPVTTFLAASTHDDKSLDEAIDMRFDC
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:24842875). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (By similarity). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (PubMed:24842875). MSL2 plays a key role in gene dosage by ensuring biallelic expression of a subset of dosage-sensitive genes, including many haploinsufficient genes (PubMed:38030723). Acts by promoting promoter-enhancer contacts, thereby preventing DNA methylation of one allele and creating a methylation-free environment for methylation-sensitive transcription factors such as SP1, KANSL1 and KANSL3 (PubMed:38030723). Also acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A (PubMed:38030723). This activity is greatly enhanced by heterodimerization with MSL1 (By similarity). H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (By similarity). {ECO:0000250|UniProtKB:Q9D1P2, ECO:0000250|UniProtKB:Q9HCI7, ECO:0000269|PubMed:24842875, ECO:0000269|PubMed:38030723}.
uniprot
proteins
mass_dalton
62538
uniprot
proteins
mutagenesis
MUTAGEN 64; /note="H->Y: Abolished E3 ubiquitin ligase activity."; /evidence="ECO:0000269|PubMed:38030723
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:38030723}.
uniprot
proteins
protein_family
MSL2 family
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
24842875
uniprot
proteins
pubmed
38030723
uniprot
proteins
sequence_length
577
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:38030723}. Chromosome {ECO:0000269|PubMed:38030723}. Note=Associates with both promoters and enhancers of target genes, maintaining promoter-enhancer contacts. {ECO:0000269|PubMed:38030723}.
uniprot
proteins