Mmp24
entrez
83513
canonical
uniprot
Q99PW6
canonical
ensembl
ENSRNOG00000047028
resolver
ensembl
ENSRNOG00055024534
resolver
ensembl
ENSRNOG00060028218
resolver
ensembl
ENSRNOG00065028413
resolver
ensp
ENSRNOP00000075211
resolver
ensp
ENSRNOP00055034461
resolver
ensp
ENSRNOP00060041008
resolver
ensp
ENSRNOP00065040152
resolver
enst
ENSRNOT00000092194
resolver
enst
ENSRNOT00055042228
resolver
enst
ENSRNOT00060049130
resolver
enst
ENSRNOT00065048964
resolver
genesymbol
Mmp24
resolver
genesymbol_syn
Mt5mmp
resolver
uniprot_entry
MMP24_RAT
resolver
amino_acid_sequence
MPRSRGGRAAPGQAARWSGWRAPGRLLPLLPALCCLAAAAGAGKPAGADAPFAGQNWLKSYGYLLPYESRASALHSGKALQSAVSTMQQFYGIPVTGVLDQTTIEWMKKPRCGVPDHPHLSRRRRNKRYALTGQKWRQKHITYSIHNYTPKVGELDTRKAIRQAFDVWQKVTPLTFEEVPYHEIKSDRKEADIMIFFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNANHDGNDLFLVAVHELGHALGLEHSNDPSAIMAPFYQYMETHNFKLPQDDLQGIQKIYGPPAEPLEPTRPLPTLPVRRIHSPSERKHERQPRPPRPPLGDRPSTPGAKPNICDGNFNTVALFRGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWEPVGKTYFFKGERYWRYSEERRATDPGYPKPITVWKGIPQAPQGAFISKEGYYTYFYKGRDYWKFDNQKLSVEPGYPRNILRDWMGCKQKEVERRKERRLPQDDVDIMVTIDDVPGSVNAVAVVVPCTLSLCLLVLLYTIFQFKNKTGPQPVTYYKRPVQEWV
uniprot
proteins
ec_number
3.4.24.-
uniprot
proteins
function
FUNCTION: Metalloprotease that mediates cleavage of N-cadherin (CDH2) and acts as a regulator of neuro-immune interactions and neural stem cell quiescence. Involved in cell-cell interactions between nociceptive neurites and mast cells, possibly by mediating cleavage of CDH2, thereby acting as a mediator of peripheral thermal nociception and inflammatory hyperalgesia. Key regulator of neural stem cells quiescence by mediating cleavage of CDH2, affecting CDH2-mediated anchorage of neural stem cells to ependymocytes in the adult subependymal zone, leading to modulate their quiescence. May play a role in axonal growth. Able to activate progelatinase A. May also be a proteoglycanase involved in degradation of proteoglycans, such as dermatan sulfate and chondroitin sulfate proteoglycans. Cleaves partially fibronectin, but not collagen type I, nor laminin. {ECO:0000269|PubMed:16495457}.
uniprot
proteins
mass_dalton
70465
uniprot
proteins
mutagenesis
MUTAGEN 616..618; /note="Missing: Impaired interaction with GRIP1 and GRIP2."; /evidence="ECO:0000269|PubMed:16495457
uniprot
proteins
post_translational_modification
PTM: Cleaved by a furin endopeptidase in the trans-Golgi network.
uniprot
proteins
protein_family
Peptidase M10A family
uniprot
proteins
pubmed
10727639
uniprot
proteins
pubmed
16495457
uniprot
proteins
sequence_length
618
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Matrix metalloproteinase-24]: Cell membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Recycled back to the plasma membrane through the trans-Golgi network via interaction with APBA3. {ECO:0000250}.; SUBCELLULAR LOCATION: [Processed matrix metalloproteinase-24]: Secreted, extracellular space, extracellular matrix {ECO:0000250}. Note=Also shed from cell surface as soluble proteinase, by a proteolytic cleavage. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 576..596; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins