RMDN3
entrez
55177
canonical
uniprot
Q96TC7
canonical
ensembl
ENSG00000137824
resolver
ensp
ENSP00000342493
resolver
ensp
ENSP00000453535
resolver
ensp
ENSP00000532190
resolver
ensp
ENSP00000621508
resolver
genesymbol
RMDN3
resolver
genesymbol_syn
FAM82A2
resolver
genesymbol_syn
FAM82C
resolver
genesymbol_syn
PTPIP51
resolver
hgnc
HGNC:25550
resolver
uniprot
A9UMZ9
resolver
uniprot
B3KRR3
resolver
uniprot
Q6ZWE9
resolver
uniprot
Q96H23
resolver
uniprot
Q96SD6
resolver
uniprot
Q9H6G1
resolver
uniprot
Q9NVQ6
resolver
uniprot_entry
RMD3_HUMAN
resolver
uniprot_sec
A9UMZ9
resolver
uniprot_sec
B3KRR3
resolver
uniprot_sec
Q6ZWE9
resolver
uniprot_sec
Q96H23
resolver
uniprot_sec
Q96SD6
resolver
uniprot_sec
Q9H6G1
resolver
uniprot_sec
Q9NVQ6
resolver
amino_acid_sequence
MSRLGALGGARAGLGLLLGTAAGLGFLCLLYSQRWKRTQRHGRSQSLPNSLDYTQTSDPGRHVMLLRAVPGGAGDASVLPSLPREGQEKVLDRLDFVLTSLVALRREVEELRSSLRGLAGEIVGEVRCHMEENQRVARRRRFPFVRERSDSTGSSSVYFTASSGATFTDAESEGGYTTANAESDNERDSDKESEDGEDEVSCETVKMGRKDSLDLEEEAASGASSALEAGGSSGLEDVLPLLQQADELHRGDEQGKREGFQLLLNNKLVYGSRQDFLWRLARAYSDMCELTEEVSEKKSYALDGKEEAEAALEKGDESADCHLWYAVLCGQLAEHESIQRRIQSGFSFKEHVDKAIALQPENPMAHFLLGRWCYQVSHLSWLEKKTATALLESPLSATVEDALQSFLKAEELQPGFSKAGRVYISKCYRELGKNSEARWWMKLALELPDVTKEDLAIQKDLEELEVILRD
uniprot
proteins
function
FUNCTION: Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis. {ECO:0000269|PubMed:16820967, ECO:0000269|PubMed:22131369}.
uniprot
proteins
mass_dalton
52118
uniprot
proteins
mutagenesis
MUTAGEN 157..172; /note="Missing: Reduces interaction with MOSPD2."; /evidence="ECO:0000269|PubMed:29858488
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-160 of the FFAT motif activates interaction with MOSPD2, VAPA and VAPB. {ECO:0000269|PubMed:33124732}.
uniprot
proteins
protein_family
RMDN family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15609043
uniprot
proteins
pubmed
16820967
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17361080
uniprot
proteins
pubmed
18070910
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22131369
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29858488
uniprot
proteins
pubmed
33124732
uniprot
proteins
sequence_length
470
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:16820967, ECO:0000269|PubMed:17361080, ECO:0000269|PubMed:22131369, ECO:0000269|PubMed:29858488}; Single-pass membrane protein {ECO:0000269|PubMed:16820967}. Cytoplasm {ECO:0000269|PubMed:17361080}. Nucleus {ECO:0000269|PubMed:17361080}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18070910}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:18070910}. Note=In interphase localizes in the cytoplasm, and during mitosis localizes to the spindle microtubules and spindle poles. {ECO:0000269|PubMed:18070910}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..35; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins