METTL2A
entrez
339175
canonical
uniprot
Q96IZ6
canonical
ensembl
ENSG00000087995
resolver
ensp
ENSP00000309610
resolver
genesymbol
METTL2A
resolver
genesymbol_syn
METTL2
resolver
hgnc
HGNC:25755
resolver
uniprot
A6NNC4
resolver
uniprot
B3KM33
resolver
uniprot
Q9H9G9
resolver
uniprot
Q9NUI8
resolver
uniprot
Q9P0B5
resolver
uniprot_entry
B3KM33_HUMAN
resolver
uniprot_entry
MET2A_HUMAN
resolver
uniprot_sec
A6NNC4
resolver
uniprot_sec
Q9H9G9
resolver
uniprot_sec
Q9NUI8
resolver
uniprot_sec
Q9P0B5
resolver
amino_acid_sequence
MAGSYPEGAPAVLADKRQQFGSRFLRDPARVFHHNAWDNVEWSEEQAAAAERKVQENSIQRVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQNHLKDWFLENKSEVPECRNNEDGPGLIMEEQHKCSSKSLEHKTQTLPVEENVTQKISDLEICADEFPGSSATYRILEVGCGVGNTVFPILQTNNDPGLFVYCCDFSSTAIELVQTNSEYDPSRCFAFVHDLCDEEKSYPVPKGSLDIIILIFVLSAIVPDKMQKAINRLSRLLKPGGMMLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKVQNLVDRRLQVNRGKQLTMYRVWIQCKYCKPLLSSTS
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU) (PubMed:28655767, PubMed:34268557). N(3)-methylcytidine methylation by METTL2A requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite (PubMed:34268557). {ECO:0000269|PubMed:28655767, ECO:0000269|PubMed:34268557}.
uniprot
proteins
mass_dalton
43537
uniprot
proteins
protein_family
METL family
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28655767
uniprot
proteins
pubmed
32427860
uniprot
proteins
pubmed
34268557
uniprot
proteins
sequence_length
378
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:34268557}.
uniprot
proteins