Neurod1
entrez
18012
canonical
uniprot
Q60867
canonical
ensembl
ENSMUSG00000034701
resolver
ensp
ENSMUSP00000040364
resolver
enst
ENSMUST00000041099
resolver
genesymbol
Neurod1
resolver
genesymbol_syn
Neurod
resolver
uniprot
Q545N9
resolver
uniprot
Q60897
resolver
uniprot_entry
NDF1_MOUSE
resolver
uniprot_sec
Q545N9
resolver
uniprot_sec
Q60897
resolver
amino_acid_sequence
MTKSYSESGLMGEPQPQGPPSWTDECLSSQDEEHEADKKEDELEAMNAEEDSLRNGGEEEEEDEDLEEEEEEEEEEEDQKPKRRGPKKKKMTKARLERFKLRRMKANARERNRMHGLNAALDNLRKVVPCYSKTQKLSKIETLRLAKNYIWALSEILRSGKSPDLVSFVQTLCKGLSQPTTNLVAGCLQLNPRTFLPEQNPDMPPHLPTASASFPVHPYSYQSPGLPSPPYGTMDSSHVFHVKPPPHAYSAALEPFFESPLTDCTSPSFDGPLSPPLSINGNFSFKHEPSAEFEKNYAFTMHYPAATLAGPQSHGSIFSSGAAAPRCEIPIDNIMSFDSHSHHERVMSAQLNAIFHD
uniprot
proteins
function
FUNCTION: Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis. {ECO:0000269|PubMed:10398678, ECO:0000269|PubMed:10639171, ECO:0000269|PubMed:11152640, ECO:0000269|PubMed:11861467, ECO:0000269|PubMed:11970861, ECO:0000269|PubMed:12810726, ECO:0000269|PubMed:14697366, ECO:0000269|PubMed:15797719, ECO:0000269|PubMed:18007592, ECO:0000269|PubMed:18339630, ECO:0000269|PubMed:19200230, ECO:0000269|PubMed:19759004, ECO:0000269|PubMed:21593321, ECO:0000269|PubMed:9308961, ECO:0000269|PubMed:9512516}.
uniprot
proteins
mass_dalton
39999
uniprot
proteins
mutagenesis
MUTAGEN 162; /note="S->A: Reduces weakly phosphorylation. Reduces strongly phosphorylation; when associated with A-259 and A-266."; /evidence="ECO:0000269|PubMed:12810726"; MUTAGEN 259; /note="S->A: Reduces weakly phosphorylation. Reduces strongly phosphorylation; when associated with A-162 and A-266. Reduces transactivation on the insulin promoter in glucose-stimulated insulinoma cells; when associated with A-266 and A-274."; /evidence="ECO:0000269|PubMed:12810726, ECO:0000269|PubMed:15797719"; MUTAGEN 266; /note="S->A: Reduces weakly phosphorylation. Reduces strongly phosphorylation; when associated with A-162 and A-259. Reduces transactivation on the insulin promoter in glucose-stimulated insulinoma cells; when associated with A-259 and A-274."; /evidence="ECO:0000269|PubMed:12810726, ECO:0000269|PubMed:15797719"; MUTAGEN 274; /note="S->A: Strongly reduces phosphorylation. Reduces transactivation on the insulin promoter in glucose-stimulated insulinoma cells; when associated with A-259 and A-266."; /evidence="ECO:0000269|PubMed:12810726, ECO:0000269|PubMed:15797719"; MUTAGEN 279; /note="I->V: Promotes the formation of differentiated late retinal amacrine cells.
uniprot
proteins
post_translational_modification
PTM: In islet cells, phosphorylated on Ser-274 upon glucose stimulation; which may be required for nuclear localization. In activated neurons, phosphorylated on Ser-336; which promotes dendritic growth (By similarity). Phosphorylated by MAPK1; phosphorylation regulates heterodimerization and DNA-binding activities. Phosphorylation on Ser-266 and Ser-274 increases transactivation on the insulin promoter in glucose-stimulated insulinoma cells. {ECO:0000250, ECO:0000269|PubMed:12810726, ECO:0000269|PubMed:15797719}.
uniprot
proteins
pubmed
10398678
uniprot
proteins
pubmed
10639171
uniprot
proteins
pubmed
11152640
uniprot
proteins
pubmed
11861467
uniprot
proteins
pubmed
11970861
uniprot
proteins
pubmed
12810726
uniprot
proteins
pubmed
14697366
uniprot
proteins
pubmed
14752053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15797719
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18007592
uniprot
proteins
pubmed
18069799
uniprot
proteins
pubmed
18339630
uniprot
proteins
pubmed
18560595
uniprot
proteins
pubmed
19200230
uniprot
proteins
pubmed
19759004
uniprot
proteins
pubmed
19854889
uniprot
proteins
pubmed
21593321
uniprot
proteins
pubmed
23395635
uniprot
proteins
pubmed
7754368
uniprot
proteins
pubmed
9308961
uniprot
proteins
pubmed
9512516
uniprot
proteins
sequence_length
357
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}. Note=In pancreatic islet cells, shuttles to the nucleus in response to glucose stimulation. Colocalizes with NR0B2 in the nucleus (By similarity). {ECO:0000250}.
uniprot
proteins