GLTP
entrez
51228
canonical
uniprot
Q9NZD2
canonical
ensembl
ENSG00000139433
resolver
ensp
ENSP00000315263
resolver
enst
ENST00000318348
resolver
genesymbol
GLTP
resolver
hgnc
HGNC:24867
resolver
uniprot
Q53Z13
resolver
uniprot
Q96J68
resolver
uniprot_entry
GLTP_HUMAN
resolver
uniprot_sec
Q53Z13
resolver
uniprot_sec
Q96J68
resolver
amino_acid_sequence
MALLAEHLLKPLPADKQIETGPFLEAVSHLPPFFDCLGSPVFTPIKADISGNITKIKAVYDTNPAKFRTLQNILEVEKEMYGAEWPKVGATLALMWLKRGLRFIQVFLQSICDGERDENHPNLIRVNATKAYEMALKKYHGWIVQKIFQAALYAAPYKSDFLKALSKGQNVTEEECLEKIRLFLVNYTATIDVIYEMYTQMNAELNYKV
uniprot
proteins
function
FUNCTION: Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides. {ECO:0000269|PubMed:15329726, ECO:0000269|PubMed:15504043, ECO:0000269|PubMed:17980653, ECO:0000269|PubMed:18261224}.
uniprot
proteins
mass_dalton
23850
uniprot
proteins
mutagenesis
MUTAGEN 45; /note="I->N: 18% decrease in activity."; /evidence="ECO:0000269|PubMed:15329726"; MUTAGEN 48; /note="D->V: Significant inactivation; 15% residual activity."; /evidence="ECO:0000269|PubMed:15329726"; MUTAGEN 52; /note="N->I: Significant inactivation; 15% residual activity."; /evidence="ECO:0000269|PubMed:15329726"; MUTAGEN 55; /note="K->I: No loss of activity; 90-97% residual activity."; /evidence="ECO:0000269|PubMed:15329726"; MUTAGEN 96; /note="W->A: Almost complete inactivation; 1-3% residual activity. No effect on autophagy."; /evidence="ECO:0000269|PubMed:15329726, ECO:0000269|PubMed:29164996"; MUTAGEN 96; /note="W->F: Partial inactivation; 63% residual activity."; /evidence="ECO:0000269|PubMed:15329726"; MUTAGEN 103; /note="F->S: About 25% decrease in activity."; /evidence="ECO:0000269|PubMed:15329726"; MUTAGEN 136; /note="L->R: Significant inactivation; 5% residual acti vity."; /evidence="ECO:0000269|PubMed:15329726"; MUTAGEN 140; /note="H->L: Almost complete inactivation; 1-3% residual activity."; /evidence="ECO:0000269|PubMed:15329726"; MUTAGEN 148; /note="F->S: About 50% decrease in activity."; /evidence="ECO:0000269|PubMed:15329726"; MUTAGEN 165; /note="L->R: 46% decrease in activity."; /evidence="ECO:0000269|PubMed:15329726"; MUTAGEN 183; /note="F->S: No loss of activity; 90% residual activity."; /evidence="ECO:0000269|PubMed:15329726"; MUTAGEN 207; /note="Y->L: No loss of activity; 90-97% residual activity."; /evidence="ECO:0000269|PubMed:15329726
uniprot
proteins
protein_family
GLTP family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15287756
uniprot
proteins
pubmed
15329726
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15504043
uniprot
proteins
pubmed
17105344
uniprot
proteins
pubmed
17980653
uniprot
proteins
pubmed
18261224
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
29164996
uniprot
proteins
sequence_length
209
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17980653}.
uniprot
proteins