Mbnl1
entrez
56758
canonical
uniprot
Q9JKP5
canonical
ensembl
ENSMUSG00000027763
resolver
ensp
ENSMUSP00000096686
resolver
ensp
ENSMUSP00000141287
resolver
ensp
ENSMUSP00000141474
resolver
ensp
ENSMUSP00000141536
resolver
ensp
ENSMUSP00000141576
resolver
ensp
ENSMUSP00000141915
resolver
ensp
ENSMUSP00000142057
resolver
ensp
ENSMUSP00000142088
resolver
ensp
ENSMUSP00000142095
resolver
ensp
ENSMUSP00000311484
resolver
ensp
ENSMUSP00000311485
resolver
ensp
ENSMUSP00000311487
resolver
ensp
ENSMUSP00000311488
resolver
ensp
ENSMUSP00000311498
resolver
enst
ENSMUST00000099087
resolver
enst
ENSMUST00000191747
resolver
enst
ENSMUST00000192607
resolver
enst
ENSMUST00000192807
resolver
enst
ENSMUST00000193517
resolver
enst
ENSMUST00000194069
resolver
genesymbol
Mbnl1
resolver
genesymbol_syn
Exp
resolver
genesymbol_syn
Mbnl
resolver
uniprot
A0A0A6YVV8
resolver
uniprot
A0A0A6YWB0
resolver
uniprot
A0A0A6YXB1
resolver
uniprot
A0A0A6YXM7
resolver
uniprot
G3X9Q0
resolver
uniprot
Q3U570
resolver
uniprot
Q3U581
resolver
uniprot
Q4VA08
resolver
uniprot_entry
A0A0A6YVV8_MOUSE
resolver
uniprot_entry
A0A0A6YWB0_MOUSE
resolver
uniprot_entry
A0A0A6YXB1_MOUSE
resolver
uniprot_entry
A0A0A6YXM7_MOUSE
resolver
uniprot_entry
G3X9Q0_MOUSE
resolver
uniprot_entry
MBNL1_MOUSE
resolver
uniprot_entry
Q3U570_MOUSE
resolver
uniprot_entry
Q3U581_MOUSE
resolver
uniprot_entry
Q4VA08_MOUSE
resolver
amino_acid_sequence
MAVSVTPIRDTKWLTLEVCREFQRGTCSRPDTECKFAHPSKSCQVENGRVIACFDSLKGRCSRENCKYLHPPPHLKTQLEINGRNNLIQQKNMAMLAQQMQLANAMMPGAPLQPVPMFSVAPSLATSASAAFNPYLGPVSPSLVPAEILPTAPMLVTGNPGVPVPAAAAAAAQKLMRTDRLEVCREYQRGNCNRGENDCRFAHPADSTMIDTNDNTVTVCMDYIKGRCSREKCKYFHPPAHLQAKIKAAQYQVNQAAAAQAAATAAAMGIPQAVLPPLPKRPALEKTNGATAVFNTGIFQYQQALANMQLQQHTAFLPPGSILCMTPATSVDTHNICRTSD
uniprot
proteins
function
FUNCTION: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs (By similarity). Together with RNA binding proteins RBPMS and RBFOX2, activates vascular smooth muscle cells alternative splicing events (By similarity). Regulates NCOR2 alternative splicing (By similarity). {ECO:0000250|UniProtKB:A0A8I6B1J2, ECO:0000250|UniProtKB:Q9NR56}.
uniprot
proteins
mass_dalton
36976
uniprot
proteins
protein_family
Muscleblind family
uniprot
proteins
pubmed
10970838
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
341
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NR56}. Cytoplasm {ECO:0000250|UniProtKB:Q9NR56}. Cytoplasmic granule {ECO:0000250|UniProtKB:Q9NR56}. Note=Localized with DDX1, TIAL1 and YBX1 in stress granules upon stress. Localized in the cytoplasm of multinucleated myotubes. {ECO:0000250|UniProtKB:Q9NR56}.
uniprot
proteins