Or51e2
entrez
170639
canonical
uniprot
Q8VBV9
canonical
ensembl
ENSMUSG00000043366
resolver
ensp
ENSMUSP00000058085
resolver
ensp
ENSMUSP00000133255
resolver
ensp
ENSMUSP00000149274
resolver
enst
ENSMUST00000060187
resolver
enst
ENSMUST00000168007
resolver
enst
ENSMUST00000217123
resolver
genesymbol
Or51e2
resolver
genesymbol_syn
Mol2.3
resolver
genesymbol_syn
Olfr78
resolver
genesymbol_syn
Psgr
resolver
uniprot_entry
O51E2_MOUSE
resolver
amino_acid_sequence
MSSCNFTHATFLLIGIPGLEEAHFWFGFPLLSMYAVALFGNCIVVFIVRTERSLHAPMYLFLCMLAAIDLALSTSTMPKILALFWFDSREITFDACLAQMFFIHTLSAIESTILLAMAFDRYVAICHPLRHAAVLNNTVTVQIGMVALVRGSLFFFPLPLLIKRLAFCHSNVLSHSYCVHQDVMKLAYTDTLPNVVYGLTAILLVMGVDVMFISLSYFLIIRTVLQLPSKSERAKAFGTCVSHISVVLAFYVPLIGLSVVHRFGNSLDPIVHVLMGDVYLLLPPVINPIIYGAKTKQIRTRVLAMFKISCDKDIEAGGNT
uniprot
proteins
function
FUNCTION: Olfactory receptor activated by short-chain fatty acids (SCFA), such as acetate and propionate (propanoate) (PubMed:23401498). Ligand-binding causes a conformation change that triggers signaling via G(s)-class of G alpha protein GNAL/G(olf), mediating activation of adenylate cyclase activity and increased production of cAMP, initiating a neuronal response that triggers the perception of a smell (By similarity). Beyond its role in olfaction, may also be activated by steroid hormones and regulate cell proliferation (By similarity). Stimulation of OR51E2 by beta-ionone affects melanocyte proliferation, differentiation, and melanogenesis (By similarity). Activation of OR51E2 by beta-ionone increases proliferation and migration of primary retinal pigment epithelial (RPE) cells (By similarity). In response to SCFA, may positively regulate renin secretion and increase blood pressure (PubMed:23401498). Activated by L-lactate in glomus cells (PubMed:26560302, PubMed:30258151). {ECO:0000250|UniProtKB:Q9H255, ECO:0000269|PubMed:23401498, ECO:0000269|PubMed:26560302, ECO:0000269|PubMed:30258151}.
uniprot
proteins
mass_dalton
35578
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11069588
uniprot
proteins
pubmed
11707321
uniprot
proteins
pubmed
11802173
uniprot
proteins
pubmed
14611657
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23401498
uniprot
proteins
pubmed
26560302
uniprot
proteins
pubmed
30258151
uniprot
proteins
pubmed
30258152
uniprot
proteins
sequence_length
320
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23401498}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:Q9H255}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 24..49; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q9H255"; TRANSMEM 60..85; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q9H255"; TRANSMEM 94..119; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q9H255"; TRANSMEM 140..164; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q9H255"; TRANSMEM 192..218; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q9H255"; TRANSMEM 237..264; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q9H255"; TRANSMEM 270..295; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q9H255
uniprot
proteins