Hbegf
entrez
15200
canonical
uniprot
Q06186
canonical
ensembl
ENSMUSG00000024486
resolver
ensp
ENSMUSP00000025363
resolver
enst
ENSMUST00000025363
resolver
genesymbol
Hbegf
resolver
genesymbol_syn
Dtr
resolver
genesymbol_syn
Hegfl
resolver
uniprot
Q5FW64
resolver
uniprot_entry
HBEGF_MOUSE
resolver
uniprot_entry
Q5FW64_MOUSE
resolver
amino_acid_sequence
MKLLPSVMLKLFLAAVLSALVTGESLERLRRGLAAATSNPDPPTGSTNQLLPTGGDRAQGVQDLEGTDLNLFKVAFSSKPQGLATPSKERNGKKKKKGKGLGKKRDPCLRKYKDYCIHGECRYLQEFRTPSCKCLPGYHGHRCHGLTLPVENPLYTYDHTTVLAVVAVVLSSVCLLVIVGLLMFRYHRRGGYDLESEEKVKLGVASSH
uniprot
proteins
function
FUNCTION: Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
uniprot
proteins
mass_dalton
22808
uniprot
proteins
post_translational_modification
PTM: O-glycosylated. {ECO:0000250}.
uniprot
proteins
pubmed
7678488
uniprot
proteins
pubmed
8647467
uniprot
proteins
sequence_length
208
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Heparin-binding EGF-like growth factor]: Secreted, extracellular space. Note=Mature HB-EGF is released into the extracellular space and probably binds to a receptor.; SUBCELLULAR LOCATION: [Proheparin-binding EGF-like growth factor]: Cell membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 161..184; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins