Sult2a1
entrez
24912
canonical
uniprot
P15709
canonical
ensembl
ENSRNOG00000078002
resolver
ensp
ENSRNOP00000070596
resolver
genesymbol
Sult2a1
resolver
genesymbol_syn
St2a1
resolver
uniprot
A0A0G2JYC0
resolver
uniprot_entry
ST2A1_RAT
resolver
uniprot_sec
A0A0G2JYC0
resolver
amino_acid_sequence
MPDYTWFEGIPFHAFGISKETLQNVCNKFVVKDEDLILLAYPKSGTNWLIEIVCLIQTKGDPKWIQSVTIWDRSPWIETDLGYDMLIKKKGPRLITSHLPMHLFSKSLFSSKAKVIYLVRNPRDVLVSGYYFWGNSTLAKKPDSLGTYVEWFLKGNVLYGSWFEHIRAWLSMREWDNFLLLYYEDMKKDTMGTIKKICDFLGKKLEPDELDLVLKYSSFQVMKENDMSNYSLLMKKSIFTGIGLMRKGTVGDWKNHFTVSQAEAFDKVFQEKMAGFPPGMFPWE
uniprot
proteins
ec_number
2.8.2.14
uniprot
proteins
ec_number
2.8.2.2
uniprot
proteins
function
FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfonation of steroids and bile acids in the liver and adrenal glands (By similarity). Mediates the sulfation of a wide range of steroids and sterols, including pregnenolone, androsterone, DHEA, bile acids, cholesterol and as well many xenobiotics that contain alcohol and phenol functional groups (PubMed:7854148). Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Plays an important role in maintening steroid and lipid homeostasis. Plays a key role in bile acid metabolism (By similarity). In addition, catalyzes the metabolic activation of potent carcinogenic polycyclic arylmethanols (PubMed:7854148). {ECO:0000250|UniProtKB:Q06520, ECO:0000269|PubMed:7854148}.
uniprot
proteins
mass_dalton
33135
uniprot
proteins
protein_family
Sulfotransferase 1 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
2590219
uniprot
proteins
pubmed
7854148
uniprot
proteins
pubmed
8033273
uniprot
proteins
sequence_length
284
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:2590219}.
uniprot
proteins