Armc12
entrez
67645
canonical
uniprot
Q80X86
canonical
ensembl
ENSMUSG00000024223
resolver
ensp
ENSMUSP00000156794
resolver
enst
ENSMUST00000233923
resolver
genesymbol
Armc12
resolver
uniprot
Q9D564
resolver
uniprot
Q9DAN7
resolver
uniprot_entry
ARM12_MOUSE
resolver
uniprot_sec
Q9D564
resolver
uniprot_sec
Q9DAN7
resolver
amino_acid_sequence
MGKTIPRFLEQLDLIKSFVGLATGAGALYLLYKAVRTGLKCHPPLCSNSPICIARLAIERERHGRDSGEIRRLLNSLDCKQDEYTRSMILHNITRCVYLLEAEASSCTMDDIDLVADMLDEKDNSVKIQALNALKAFSGIRKFRLKIQEHCIKVLELISTIWDLELHVAGLRLLNNLPLPDYVHPQLRRVMPALMEIIQSDCILAQVQAVRLLSYLAQKNDLLYDILNCQVRPNFLNLFQSSQPGSLLFEVLVFAEHLSEGRNATHYRAVKWHYNEQSLHEALFGDESRLADRLLSLVIHPEEEVQIQACKVIVSLQCPQDLGSRPSSCRPSHSCFKTGK
uniprot
proteins
function
FUNCTION: Essential for male fertility and sperm mitochondrial sheath formation (PubMed:33536340, PubMed:35534203). Required for proper mitochondrial elongation and coiling along the flagellum during the formation of the mitochondrial sheath (PubMed:33536340). Facilitates the growth and aggressiveness of neuroblastoma cells (By similarity). Increases the EZH2 activity and H3K27me3 levels in a RBBP4-dependent manner, and facilitates the enrichment of polycomb repressive complex 2 and H3K27me3 on gene promoters, resulting in transcriptional repression of tumor suppressors affecting the proliferation, invasion, and metastasis of tumor cells (By similarity). {ECO:0000250|UniProtKB:Q5T9G4, ECO:0000269|PubMed:33536340, ECO:0000269|PubMed:35534203}.
uniprot
proteins
mass_dalton
38530
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
33536340
uniprot
proteins
pubmed
35534203
uniprot
proteins
sequence_length
340
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5T9G4}. Mitochondrion outer membrane {ECO:0000269|PubMed:33536340}; Peripheral membrane protein {ECO:0000269|PubMed:33536340}.
uniprot
proteins