Atp11c
entrez
320940
canonical
uniprot
Q9QZW0
canonical
ensembl
ENSMUSG00000062949
resolver
ensp
ENSMUSP00000033480
resolver
ensp
ENSMUSP00000099066
resolver
ensp
ENSMUSP00000245317
resolver
ensp
ENSMUSP00000245318
resolver
ensp
ENSMUSP00000245319
resolver
enst
ENSMUST00000033480
resolver
genesymbol
Atp11c
resolver
uniprot
E9QKK8
resolver
uniprot
Q3KQR4
resolver
uniprot_entry
AT11C_MOUSE
resolver
uniprot_entry
E9QKK8_MOUSE
resolver
uniprot_sec
Q3KQR4
resolver
amino_acid_sequence
MFRRTLNRLCAGEEKRVGTRTVFVGNHPISGTEPYIAQRFCDNRIVSSKYTLWNFLPKNLFEQFRRIANFYFLIIFLVQVTVDTPTSPVTSGLPLFFVITVTAIKQGYEDWLRHRADNEVNKSAVYIIENAKRVRKESEKIKVGDVVEVQANETFPCDLILLSSCTTDGTCYVTTASLDGESNCKTHYAVRDTIALCTAESIDNLRATIECEQPQPDLYRFVGRISIYSNSIEAVARSLGPENLLLKGATLKNTKKIYGVAVYTGMETKMALNYQGKSQKCSAVEKSINAFLIVYLFILLTKAAVCTTLKYVWQSSPYNDEPWYNQKTQKERETFQVLKMFTDFLSFMVLFNFIIPVSMYVTVEMQKFLGSFFISWDKDFFDEEINEGALVNTSDLNEELGQVDYVFTDKTGTLTENSMEFIECCIDGHKYKGTTQEVDGLSQTDGPLAYFDKADKNREALFLRALCLCHTVEMKTNDDVDGPVEGAGFTYISSSPDEIALVKGAKRFGFTFLGNQNGYIRVENQRKEIEEYELLHTLNFDSVRRRMSVIVRTQKGDILLFCKGADSSIFPRVHSHQIELTKDHVERNAMDGYRTLCVAFKEIPPDDFERINAQLVEAKMALQDREEKLEKVFDEIETNMNLIGATAVEDKLQDQAAETIEALHAAGLKVWVLTGDKMETAKSTCYACRLFQTNTELLELTTKTIEESERKEDRLHELLIEYRKKLLHEFPKSTRSLKKAWTEHQEYGLIIDGSTLSLILNSSQDCSSNNYKSIFLQICMKCTAVLCCRMAPLQKAQIVRMVKNLKGSPITLSIGDGANDVSMILESHVGIGIKGKEGRQAARNSDYSVPKFKHLKKLLLVHGHLYYVRIAHLVQYFFYKNLCFILPQFLYQFFCGFSQQPLYDAAYLTMYNICFTSLPILAYSLLEQHINIDTLTADPRLYMKITGNAMLQLGPFLHWTFLAAFEGTVFFFGTYFLFQTSSLEDNGKIYGNWTFGTIVFTVLVFTVTLKLALDTRFWTWINHFVIWGSLAFYVFFSFFWGGIIWPFLKQQRMYFVFAQMLCSVSTWLAIILLIFISLFPEILLIVVKNVRRRSARRNLSCRRASDSLSARPSVRPLLLRTFSDESNIL
uniprot
proteins
disease_involvement
DISEASE: Note=Mice defective in Atp11c show defective B lymphopoiesis, specifically in mature bone marrow, pronounced stomatocytosis associated with anemia, hyperbilirubinemia linked to mild cholestasis and hepatocellular carcinoma. {ECO:0000269|PubMed:21423173, ECO:0000269|PubMed:21518881, ECO:0000269|PubMed:24898253}.
uniprot
proteins
ec_number
7.6.2.1
uniprot
proteins
function
FUNCTION: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane (PubMed:24898253, PubMed:24904167, PubMed:26799398, PubMed:30018401). Major PS-flippase in immune cell subsets (PubMed:30018401). In erythrocyte plasma membrane, it is required to maintain PS in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for erythrocyte clearance by splenic macrophages (PubMed:24898253). Required for B cell differentiation past the pro-B cell stage (PubMed:21423173). Seems to mediate PS flipping in pro-B cells (PubMed:21423172, PubMed:26799398). May be involved in the transport of cholestatic bile acids (PubMed:21518881). {ECO:0000269|PubMed:21423172, ECO:0000269|PubMed:21423173, ECO:0000269|PubMed:21518881, ECO:0000269|PubMed:24898253, ECO:0000269|PubMed:24904167, ECO:0000269|PubMed:26799398, ECO:0000269|PubMed:30018401}.
uniprot
proteins
mass_dalton
129240
uniprot
proteins
mutagenesis
MUTAGEN 181; /note="E->Q: Impairs ATPase activity."; /evidence="ECO:0000269|PubMed:30018401
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved by CASP3, CASP6 and CASP7. {ECO:0000250|UniProtKB:Q8NB49}.; PTM: Phosphorylated at Ser-1113 likely by PRKCA; this creates a functional di-leucine motif that is sufficient for endocytosis. {ECO:0000250|UniProtKB:Q8NB49}.
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type IV subfamily
uniprot
proteins
pubmed
11015572
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21423172
uniprot
proteins
pubmed
21423173
uniprot
proteins
pubmed
21518881
uniprot
proteins
pubmed
24898253
uniprot
proteins
pubmed
24904167
uniprot
proteins
pubmed
26799398
uniprot
proteins
pubmed
30018401
uniprot
proteins
sequence_length
1129
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8NB49}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8NB49}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:Q8NB49}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q8NB49}; Multi-pass membrane protein {ECO:0000255}. Note=Efficient exit from the endoplasmic reticulum requires the presence of CDC50A. Internalized via clathrin-dependent endocytosis in response to ca(2+) signaling induced by G protein coupled serotonin and histamine receptors, HTR2A and HRH1 respectively. {ECO:0000250|UniProtKB:Q8NB49}.
uniprot
proteins
transmembrane_region
TRANSMEM 84..104; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 288..308; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 344..364; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 877..897; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 906..926; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 953..973; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 989..1009; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1024..1044; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1067..1087; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins