TMEM59
entrez
9528
canonical
uniprot
Q9BXS4
canonical
ensembl
ENSG00000116209
resolver
ensp
ENSP00000234831
resolver
ensp
ENSP00000360388
resolver
ensp
ENSP00000360392
resolver
ensp
ENSP00000360395
resolver
ensp
ENSP00000360399
resolver
ensp
ENSP00000534637
resolver
ensp
ENSP00000773379
resolver
ensp
ENSP00000798746
resolver
enst
ENST00000234831
resolver
enst
ENST00000371337
resolver
enst
ENST00000371341
resolver
enst
ENST00000371344
resolver
enst
ENST00000371348
resolver
genesymbol
TMEM59
resolver
genesymbol_syn
C1orf8
resolver
hgnc
HGNC:1239
resolver
uniprot
A0A9K3Y7R5
resolver
uniprot
B3KQL7
resolver
uniprot
D3DQ49
resolver
uniprot
O75393
resolver
uniprot
Q4VBP9
resolver
uniprot
Q5T6Z8
resolver
uniprot
Q5T703
resolver
uniprot
Q5T705
resolver
uniprot
Q96KX7
resolver
uniprot_entry
Q5T6Z8_HUMAN
resolver
uniprot_entry
Q5T703_HUMAN
resolver
uniprot_entry
TMM59_HUMAN
resolver
uniprot_sec
A0A9K3Y7R5
resolver
uniprot_sec
B3KQL7
resolver
uniprot_sec
D3DQ49
resolver
uniprot_sec
O75393
resolver
uniprot_sec
Q4VBP9
resolver
uniprot_sec
Q5T705
resolver
uniprot_sec
Q96KX7
resolver
amino_acid_sequence
MAAPKGSLWVRTQLGLPPLLLLTMALAGGSGTASAEAFDSVLGDTASCHRACQLTYPLHTYPKEEELYACQRGCRLFSICQFVDDGIDLNRTKLECESACTEAYSQSDEQYACHLGCQNQLPFAELRQEQLMSLMPKMHLLFPLTLVRSFWSDMMDSAQSFITSSWTFYLQADDGKIVIFQSKPEIQYAPHLEQEPTNLRESSLSKMSYLQMRNSQAHRNFLEDGESDGFLRCLSLNSGWILTTTLVLSVMVLLWICCATVATAVEQYVPSEKLSIYGDLEFMNEQKLNRYPASSLVVVRSKTEDHEEAGPLPTKVNLAHSEI
uniprot
proteins
function
FUNCTION: Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy (PubMed:23376921, PubMed:27273576). Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP (PubMed:20427278). Inhibits APP transport to the cell surface and further shedding (PubMed:20427278). {ECO:0000269|PubMed:20427278, ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:27273576}.
uniprot
proteins
mass_dalton
36223
uniprot
proteins
mutagenesis
MUTAGEN 268; /note="Y->A,F: Impaired ability to activate LC3. Impaired interaction with ATG16L1."; /evidence="ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:27273576"; MUTAGEN 268; /note="Y->W: Does not affect ability to activate LC3."; /evidence="ECO:0000269|PubMed:23376921"; MUTAGEN 269; /note="V->A: No effect on interaction with ATG16L1."; /evidence="ECO:0000269|PubMed:27273576"; MUTAGEN 272; /note="E->A,D: Does not affect ability to activate LC3. No effect on interaction with ATG16L1."; /evidence="ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:27273576"; MUTAGEN 273; /note="K->A: No effect on interaction with ATG16L1."; /evidence="ECO:0000269|PubMed:27273576"; MUTAGEN 277; /note="Y->A: Impaired ability to activate LC3. Impaired interaction with ATG16L1."; /evidence="ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:27273576"; MUTAGEN 277; /note="Y->W,F: Does not affect ability to activate LC3."; /evidence="ECO:0000269|PubMed:23376921"; MUTAGEN 278; /note="G->A: No effect on interaction with ATG16L1."; /evidence="ECO:0000269|PubMed:27273576"; MUTAGEN 280; /note="L->A,V: Impaired ability to activate LC3. Impaired interaction with ATG16L1."; /evidence="ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:27273576
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:20427278}.
uniprot
proteins
protein_family
TMEM59 family
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
20427278
uniprot
proteins
pubmed
23376921
uniprot
proteins
pubmed
27273576
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:27273576}; Single-pass type I membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:23376921, ECO:0000269|PubMed:27273576}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:23376921}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:20427278}; Single-pass type I membrane protein {ECO:0000255}. Note=Mainly localizes to late endosomes/lysosomes. Probably first exported to the cell surface and then actively endocytosed to transiently localize in early endosomes on its way to the late endosomal/lysosomal compartment where it becomes quickly degraded. {ECO:0000269|PubMed:23376921}.
uniprot
proteins
transmembrane_region
TRANSMEM 239..259; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins