Ppil1
entrez
68816
canonical
uniprot
Q9D0W5
canonical
ensembl
ENSMUSG00000024007
resolver
ensp
ENSMUSP00000024802
resolver
enst
ENSMUST00000024802
resolver
genesymbol
Ppil1
resolver
uniprot
B9EJX8
resolver
uniprot
Q3UA03
resolver
uniprot_entry
B9EJX8_MOUSE
resolver
uniprot_entry
PPIL1_MOUSE
resolver
uniprot_sec
Q3UA03
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by Cyclosporin A. {ECO:0000250|UniProtKB:Q9Y3C6}.
uniprot
proteins
amino_acid_sequence
MAAIPPDTWQPPNVYLETSMGVIVLELYWKHAPKTCKNFAELARRGYYNGTKFHRIIKDFMIQGGDPTGTGRGGASIYGKQFEDELHPDLKFTGAGILAMANAGPDTNGSQFFVTLAPTQWLDGKHTIFGRVCQGIGMVNRVGMVETNSQDRPVDDVKILKAYPSG
uniprot
proteins
ec_number
5.2.1.8
uniprot
proteins
function
FUNCTION: Involved in pre-mRNA splicing as component of the spliceosome (PubMed:33220177). PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). Catalyzes prolyl peptide bond isomerization in CDC40/PRP17 (By similarity). Plays an important role in embryonic brain development; this function is independent of its isomerase activity (PubMed:33220177). {ECO:0000250|UniProtKB:Q9Y3C6, ECO:0000269|PubMed:33220177}.
uniprot
proteins
mass_dalton
18237
uniprot
proteins
mutagenesis
MUTAGEN 55; /note="R->A: Loss of isomerase activity. No phenotype when introduced in mice, animals are viable and fertile with no microcephaly or defective cortical lamination; no splicing defect."; /evidence="ECO:0000269|PubMed:33220177
uniprot
proteins
protein_family
Cyclophilin-type PPIase family
uniprot
proteins
protein_family
PPIL1 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
33220177
uniprot
proteins
sequence_length
166
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y3C6}.
uniprot
proteins