Mbl2
entrez
17195
canonical
uniprot
P41317
canonical
ensembl
ENSMUSG00000024863
resolver
ensp
ENSMUSP00000025797
resolver
ensp
ENSMUSP00000189326
resolver
ensp
ENSMUSP00000189328
resolver
enst
ENSMUST00000025797
resolver
genesymbol
Mbl2
resolver
uniprot
Q3UEK1
resolver
uniprot_entry
MBL2_MOUSE
resolver
uniprot_entry
Q3UEK1_MOUSE
resolver
amino_acid_sequence
MSIFTSFLLLCVVTVVYAETLTEGVQNSCPVVTCSSPGLNGFPGKDGRDGAKGEKGEPGQGLRGLQGPPGKVGPTGPPGNPGLKGAVGPKGDRGDRAEFDTSEIDSEIAALRSELRALRNWVLFSLSEKVGKKYFVSSVKKMSLDRVKALCSEFQGSVATPRNAEENSAIQKVAKDIAYLGITDVRVEGSFEDLTGNRVRYTNWNDGEPNNTGDGEDCVVILGNGKWNDVPCSDSFLAICEFSD
uniprot
proteins
function
FUNCTION: Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. Specifically recognizes and binds the mannose moiety of carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway. {ECO:0000250|UniProtKB:P11226}.
uniprot
proteins
mass_dalton
25957
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1712818
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7766991
uniprot
proteins
sequence_length
244
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P11226}. Cell surface {ECO:0000250|UniProtKB:P11226}. Note=Specifically binds mannose moiety of carbohydrates on the surface of pathogens. {ECO:0000250|UniProtKB:P11226}.
uniprot
proteins