NUPR1
entrez
26471
canonical
uniprot
O60356
canonical
ensembl
ENSG00000176046
resolver
ensp
ENSP00000315559
resolver
ensp
ENSP00000379003
resolver
genesymbol
NUPR1
resolver
genesymbol_syn
COM1
resolver
hgnc
HGNC:29990
resolver
uniprot
B2R5C4
resolver
uniprot
O60357
resolver
uniprot
Q6FGG3
resolver
uniprot_entry
NUPR1_HUMAN
resolver
uniprot_sec
B2R5C4
resolver
uniprot_sec
O60357
resolver
uniprot_sec
Q6FGG3
resolver
amino_acid_sequence
MATFPPATSAPQQPPGPEDEDSSLDESDLYSLAHSYLGGGGRKGRTKREAAANTNRPSPGGHERKLVTKLQNSERKKRGARR
uniprot
proteins
function
FUNCTION: Transcription regulator that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Thereby participates in the regulation of many processes namely cell-cycle, apoptosis, autophagy and DNA repair responses (PubMed:11056169, PubMed:11940591, PubMed:16300740, PubMed:16478804, PubMed:18690848, PubMed:19650074, PubMed:19723804, PubMed:20181828, PubMed:22565310, PubMed:22858377, PubMed:30451898). Controls cell cycle progression and protects cells from genotoxic stress induced by doxorubicin through the complex formation with TP53 and EP300 that binds CDKN1A promoter leading to transcriptional induction of CDKN1A (PubMed:18690848). Protects pancreatic cancer cells from stress-induced cell death by binding the RELB promoter and activating its transcription, leading to IER3 transactivation (PubMed:22565310). Negatively regulates apoptosis through interaction with PTMA (PubMed:16478804). Inhibits autophagy-induced apoptosis in cardiac cells through FOXO3 interaction, inducing cytoplasmic translocation of FOXO3 thereby preventing the FOXO3 association with the pro-autophagic BNIP3 promoter (PubMed:20181828). Inhibits cell growth and facilitates programmed cell death by apoptosis after adriamycin-induced DNA damage through transactivation of TP53 (By similarity). Regulates methamphetamine-induced apoptosis and autophagy through DDIT3-mediated endoplasmic reticulum stress pathway (By similarity). Participates in DNA repair following gamma-irradiation by facilitating DNA access of the transcription machinery through interaction with MSL1 leading to inhibition of histone H4 'Lys-16' acetylation (H4K16ac) (PubMed:19650074). Coactivator of PAX2 transcription factor activity, both by recruiting EP300 to increase PAX2 transcription factor activity and by binding PAXIP1 to suppress PAXIP1-induced inhibition on PAX2 (PubMed:11940591). Positively regulates cell cycle progression through interaction with COPS5 inducing cytoplasmic translocation of CDKN1B leading to the CDKN1B degradation (PubMed:16300740). Coordinates, through its interaction with EP300, the association of MYOD1, EP300 and DDX5 to the MYOG promoter, leading to inhibition of cell-cycle progression and myogenic differentiation promotion (PubMed:19723804). Negatively regulates beta cell proliferation via inhibition of cell-cycle regulatory genes expression through the suppression of their promoter activities (By similarity). Also required for LHB expression and ovarian maturation (By similarity). Exacerbates CNS inflammation and demyelination upon cuprizone treatment (By similarity). {ECO:0000250|UniProtKB:O54842, ECO:0000250|UniProtKB:Q9WTK0, ECO:0000269|PubMed:11056169, ECO:0000269|PubMed:11940591, ECO:0000269|PubMed:16300740, ECO:0000269|PubMed:16478804, ECO:0000269|PubMed:18690848, ECO:0000269|PubMed:19650074, ECO:0000269|PubMed:19723804, ECO:0000269|PubMed:20181828, ECO:0000269|PubMed:22565310, ECO:0000269|PubMed:22858377, ECO:0000269|PubMed:30451898}.
uniprot
proteins
mass_dalton
8873
uniprot
proteins
mutagenesis
MUTAGEN 33; /note="A->Q: Impairs interaction with RNF2."; /evidence="ECO:0000269|PubMed:28720707"; MUTAGEN 68; /note="T->Q: Impairs interaction with RNF2."; /evidence="ECO:0000269|PubMed:28720707
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in vitro by PKA and CK. Phosphorylation promotes DNA-binding activity. {ECO:0000269|PubMed:11056169}.; PTM: Acetylated by EP300 in vitro. {ECO:0000269|PubMed:11940591}.
uniprot
proteins
protein_family
NUPR family
uniprot
proteins
pubmed
10092851
uniprot
proteins
pubmed
10493524
uniprot
proteins
pubmed
10493829
uniprot
proteins
pubmed
11056169
uniprot
proteins
pubmed
11940591
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16300740
uniprot
proteins
pubmed
16341674
uniprot
proteins
pubmed
16478804
uniprot
proteins
pubmed
18690848
uniprot
proteins
pubmed
19650074
uniprot
proteins
pubmed
19723804
uniprot
proteins
pubmed
20181828
uniprot
proteins
pubmed
22565310
uniprot
proteins
pubmed
22858377
uniprot
proteins
pubmed
28720707
uniprot
proteins
pubmed
30451898
uniprot
proteins
sequence_length
82
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10092851, ECO:0000269|PubMed:16300740}. Cytoplasm {ECO:0000269|PubMed:16300740}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16300740}.
uniprot
proteins