Tbc1d21
entrez
74286
canonical
uniprot
Q9D9D3
canonical
ensembl
ENSMUSG00000036244
resolver
ensp
ENSMUSP00000037525
resolver
ensp
ENSMUSP00000360091
resolver
enst
ENSMUST00000040217
resolver
genesymbol
Tbc1d21
resolver
genesymbol_syn
MgcRabGAP
resolver
uniprot
B7ZNH3
resolver
uniprot_entry
TBC21_MOUSE
resolver
uniprot_sec
B7ZNH3
resolver
amino_acid_sequence
MTTLSPENSLSARRSATFILEKRNPPIDKAEWDSFFDENGHLAKSRDFICINILERGLHPFVRTEAWKFLTGYYSWQSSRDERLMVDSNRRRNYNSLCQMYEKIQPLLENLHGNFTETRNNIAYDIQRLYDKDPLGNVLIDKKKLEKTLLLSYVCNTKAEYQRGFHEMVMLFQLMVEHDHETFWLFQFFLQKTEHSCVINIGVGKNLDMLNSLITLLDPEFAEHLKGKGSGAVQSLFPWFCLCFQRAFKTFDDVWRLWEVLLTGKPCRNFQVLVAYSMLQMVREQALLECMSGDAILMACNNLIDLDADELISAACVVYSELMQKEVPQPLKEFLL
uniprot
proteins
function
FUNCTION: Acts as a GTPase-activating protein for Rab family protein (s) (PubMed:30360518). Essential for the establishment of male fertility, and is required for both the production of normal sperm number and sperm function (PubMed:32976492). Plays an important role in the formation of intact mitochondria, outer dense fibers and axoneme within the sperm tail (PubMed:32976492). Essential for sperm mitochondrial sheath formation and for the interactions of ARMC12 with VDAC2 and VDAC3 (PubMed:33536340). May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity (PubMed:21128978). {ECO:0000269|PubMed:30360518, ECO:0000269|PubMed:32976492, ECO:0000269|PubMed:33536340, ECO:0000305|PubMed:21128978}.
uniprot
proteins
mass_dalton
39261
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21128978
uniprot
proteins
pubmed
30360518
uniprot
proteins
pubmed
32976492
uniprot
proteins
pubmed
33536340
uniprot
proteins
sequence_length
336
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:21128978}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:21128978}. Note=Located at the edge of the acrosomal region, neck and annulus during spermiogenesis. Colocalizes with RAB3A at the acrosome-acroplaxome and neck regions of spermatids. Colocalizes with ACTB at the neck region in elongated spermatids. {ECO:0000269|PubMed:21128978}.
uniprot
proteins