Nde1
entrez
67203
canonical
uniprot
Q9CZA6
canonical
ensembl
ENSMUSG00000022678
resolver
ensp
ENSMUSP00000023359
resolver
ensp
ENSMUSP00000111461
resolver
ensp
ENSMUSP00000112817
resolver
genesymbol
Nde1
resolver
genesymbol_syn
Nude
resolver
uniprot
Q3UBS6
resolver
uniprot
Q3UIC1
resolver
uniprot
Q9ERR0
resolver
uniprot_entry
NDE1_MOUSE
resolver
uniprot_sec
Q3UBS6
resolver
uniprot_sec
Q3UIC1
resolver
uniprot_sec
Q9ERR0
resolver
amino_acid_sequence
MEDSGKTFESEEEETNYWRDLAMTYKQRAENTQEELREFQEGSREYEAELEAQLQQIETRNRDLLSENNRLRMELESVKEKFEMQHSEGYRQISALEDDLAQTKAIKDQLQKYIRELEQANDDLERAKRATIMSLEDFEQRLNQAIERNAFLESELDEKENLLESVQRLKDEARDLRQELAVQQKQDKPRTPMPGSGQAKRTDMAVQATGSVPSTPVAHRGPSSGLNTPGMFRRGLDSSTSGTPLTPAARISALNIVGDLLRKVGALESKLASCRNFMYDQSPSRTSGPASGRGTKNRDGVDRRPGSTSVGDKGSGKRLEFGKPASEPASPALPSAQGVVKLLL
uniprot
proteins
function
FUNCTION: Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a postmitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. Acts as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network (By similarity). {ECO:0000250|UniProtKB:Q9NXR1, ECO:0000269|PubMed:15473967}.
uniprot
proteins
mass_dalton
38523
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in mitosis (By similarity). Phosphorylation at Thr-246 is essential for the G2/M transition (PubMed:21529751). {ECO:0000250|UniProtKB:Q9NXR1, ECO:0000269|PubMed:21529751}.
uniprot
proteins
protein_family
NudE family
uniprot
proteins
pubmed
11163258
uniprot
proteins
pubmed
11163259
uniprot
proteins
pubmed
15473967
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15939891
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21529751
uniprot
proteins
sequence_length
344
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Cleavage furrow. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9NXR1}. Note=Localizes to the interphase and S phase centrosome. During mitosis, partially associated with the mitotic spindle. Concentrates at the plus ends of microtubules coincident with kinetochores in metaphase and anaphase in a CENPF-dependent manner. Also localizes to the cleavage furrow during cytokinesis. Also localizes to the cleavage furrow during cytokinesis. Colocalizes with RAB9A to membrane vesicles (By similarity). {ECO:0000250|UniProtKB:Q9NXR1}.
uniprot
proteins