EHD2
entrez
30846
canonical
uniprot
Q9NZN4
canonical
ensembl
ENSG00000024422
resolver
ensp
ENSP00000263277
resolver
genesymbol
EHD2
resolver
genesymbol_syn
PAST2
resolver
hgnc
HGNC:3243
resolver
uniprot
B2RDH9
resolver
uniprot
B4DNU6
resolver
uniprot
Q96CB6
resolver
uniprot_entry
EHD2_HUMAN
resolver
uniprot_sec
B2RDH9
resolver
uniprot_sec
B4DNU6
resolver
uniprot_sec
Q96CB6
resolver
activity_regulation
ACTIVITY REGULATION: The very low intrinsic ATPase activity is increased upon interaction with liposomes. {ECO:0000250|UniProtKB:Q8BH64}.
uniprot
proteins
amino_acid_sequence
MFSWLKRGGARGQQPEAIRTVTSALKELYRTKLLPLEEHYRFGAFHSPALEDADFDGKPMVLVAGQYSTGKTSFIQYLLEQEVPGSRVGPEPTTDCFVAVMHGDTEGTVPGNALVVDPDKPFRKLNPFGNTFLNRFMCAQLPNQVLESISIIDTPGILSGAKQRVSRGYDFPAVLRWFAERVDLIILLFDAHKLEISDEFSEAIGALRGHEDKIRVVLNKADMVETQQLMRVYGALMWALGKVVGTPEVLRVYIGSFWSQPLLVPDNRRLFELEEQDLFRDIQGLPRHAALRKLNDLVKRARLVRVHAYIISYLKKEMPSVFGKENKKKQLILKLPVIFAKIQLEHHISPGDFPDCQKMQELLMAHDFTKFHSLKPKLLEALDEMLTHDIAKLMPLLRQEELESTEVGVQGGAFEGTHMGPFVERGPDEAMEDGEEGSDDEAEWVVTKDKSKYDEIFYNLAPADGKLSGSKAKTWMVGTKLPNSVLGRIWKLSDVDRDGMLDDEEFALASHLIEAKLEGHGLPANLPRRLVPPSKRRHKGSAE
uniprot
proteins
function
FUNCTION: ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis (By similarity). Plays a role in membrane trafficking between the plasma membrane and endosomes (PubMed:17233914). Important for the internalization of GLUT4. Required for fusion of myoblasts to skeletal muscle myotubes. Required for normal translocation of FER1L5 to the plasma membrane (By similarity). Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by constraining caveolae at the cell membrane (PubMed:25588833). {ECO:0000250|UniProtKB:Q8BH64, ECO:0000269|PubMed:17233914, ECO:0000269|PubMed:25588833}.
uniprot
proteins
mass_dalton
61161
uniprot
proteins
mutagenesis
MUTAGEN 72; /note="T->A: Incapable of binding membranes and localizing to caveolae."; /evidence="ECO:0000269|PubMed:22323287"; MUTAGEN 94; /note="T->A: Lowers the level of CAV1; distorded caveolae."; /evidence="ECO:0000269|PubMed:22323287"; MUTAGEN 120; /note="K->N: Complete loss of localization to CAV1 positive caveolae."; /evidence="ECO:0000269|PubMed:22323287"; MUTAGEN 122; /note="F->A: Complete loss of localization to CAV1 positive caveolae."; /evidence="ECO:0000269|PubMed:22323287"; MUTAGEN 128; /note="F->A: No effect on caveolae targeting."; /evidence="ECO:0000269|PubMed:22323287"; MUTAGEN 192; /note="H->D: Distorded caveolae."; /evidence="ECO:0000269|PubMed:22323287"; MUTAGEN 193; /note="K->D: Distorded caveolae."; /evidence="ECO:0000269|PubMed:22323287
uniprot
proteins
protein_family
Dynamin/Fzo/YdjA family
uniprot
proteins
protein_family
EHD subfamily
uniprot
proteins
protein_family
TRAFAC class dynamin-like GTPase superfamily
uniprot
proteins
pubmed
10673336
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15242332
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17233914
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18502764
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22323287
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25588833
uniprot
proteins
sequence_length
543
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17233914}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8BH64}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8BH64}. Membrane, caveola {ECO:0000269|PubMed:22323287}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8BH64}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8BH64}. Endosome membrane {ECO:0000250|UniProtKB:Q4V8H8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q4V8H8}; Cytoplasmic side {ECO:0000250|UniProtKB:Q4V8H8}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8BH64}. Note=Colocalizes with GLUT4 in intracellular tubulovesicular structures that are associated with cortical F-actin. Colocalizes with FER1L5 at plasma membrane in myoblasts and myotubes. {ECO:0000250|UniProtKB:Q8BH64}.
uniprot
proteins