Q99PN0
uniprot
Q99PN0
canonical
activity_regulation
ACTIVITY REGULATION: Perchlorate inhibits iodide transport activity (PubMed:32084174). Oxyanions inhibit iodide transport activity by blocking the binding sites for iodide and one of the sodium ions (By similarity). {ECO:0000250|UniProtKB:Q63008, ECO:0000269|PubMed:32084174}.
uniprot
proteins
amino_acid_sequence
MEGAEAGARATFGPWDYGVFATMLLVSTGIGLWVGLARGGQRSADDFFTGGRQLAAVPVGLSLAASFMSAVQVLGVPAEAARYGLKFLWMCVGQLLNSLLTALLFLPIFYRLGLTSTYQYLELRFSRAVRLCGTLQYLVATMLYTGIVIYAPALILNQVTGLDIWASLLSTGIICTLYTTVGGMKAVVWTDVFQVVVMLVGFWVILARGVMLMGGPWNVLSLAQNHSRINLMDFDPDPRSRYTFWTFVVGGSLVWLSMYGVNQAQVQRYVACHTERKAKLALLVNQLGLFLIVASAACCGIVMFVYYKDCDPLLTGRIAAPDQYMPLLVLDIFEDLPGVPGLFLACAYSGTLSTASTSINAMAAVTVEDLIKPRMPSLAPRKLVFISKGLSFIYGSTCLTVAALSSLLGGGVLQGSFTVMGVISGPLLGAFTLGMLLPACNTPGVLSGLTAGLAVSLWVAVGATLYPPGEQTMGVLPTSAAGCTNASVLPSPPGAANTSRGIPSSGMDSGRPAFADTFYAVSYLYYGALGTLTTMLCGALISYLTGPTKRSSLGPGLLWWDLARQTASVAPKEDTTTLEDSLVKGPEDIPAATKKPPGFRPEAETHPLYLGHDVETNL
uniprot
proteins
function
FUNCTION: Sodium:iodide symporter that mediates the transport of iodide into the thyroid gland (PubMed:11716040, PubMed:18372236, PubMed:32084174). Can also mediate the transport of chlorate, thiocynate, nitrate and selenocynate (By similarity). {ECO:0000250|UniProtKB:Q92911, ECO:0000269|PubMed:11716040, ECO:0000269|PubMed:18372236, ECO:0000269|PubMed:32084174}.
uniprot
proteins
mass_dalton
65568
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:18372236}.
uniprot
proteins
protein_family
Sodium:solute symporter (SSF) (TC 2.A.21) family
uniprot
proteins
pubmed
11716040
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18372236
uniprot
proteins
pubmed
32084174
uniprot
proteins
sequence_length
618
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18372236}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q63008}. Cytoplasm {ECO:0000269|PubMed:18372236}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..31; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q63008"; TRANSMEM 57..80; /note="Discontinuously helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q63008"; TRANSMEM 85..105; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q63008"; TRANSMEM 131..157; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q63008"; TRANSMEM 164..181; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q63008"; TRANSMEM 190..208; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q63008"; TRANSMEM 244..266; /note="Discontinuously helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q63008"; TRANSMEM 279..301; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q63008"; TRANSMEM 336..363; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q63008"; TRANSMEM 387..408; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q63008"; TRANSMEM 412..437; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q63008"; TRANSMEM 442..465; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:Q63008"; TRANSMEM 521..545; /note="Helical; Name=13"; /evidence="ECO:0000250|UniProtKB:Q63008
uniprot
proteins