TIMP3
entrez
7078
canonical
uniprot
P35625
canonical
ensembl
ENSG00000100234
resolver
ensp
ENSP00000266085
resolver
ensp
ENSP00000579043
resolver
enst
ENST00000266085
resolver
enst
ENST00000908984
resolver
genesymbol
TIMP3
resolver
hgnc
HGNC:11822
resolver
uniprot
B2RBY9
resolver
uniprot
Q5THV4
resolver
uniprot
Q9UC74
resolver
uniprot
Q9UGS2
resolver
uniprot_entry
TIMP3_HUMAN
resolver
uniprot_sec
B2RBY9
resolver
uniprot_sec
Q5THV4
resolver
uniprot_sec
Q9UC74
resolver
uniprot_sec
Q9UGS2
resolver
amino_acid_sequence
MTPWLGLIVLLGSWSLGDWGAEACTCSPSHPQDAFCNSDIVIRAKVVGKKLVKEGPFGTLVYTIKQMKMYRGFTKMPHVQYIHTEASESLCGLKLEVNKYQYLLTGRVYDGKMYTGLCNFVERWDQLTLSQRKGLNYRYHLGCNCKIKSCYYLPCFVTSKNECLWTDMLSNFGYPGYQSKHYACIRQKGGYCSWYRGWAPPDKSIINATDP
uniprot
proteins
disease_involvement
DISEASE: Sorsby fundus dystrophy (SFD) [MIM:136900]: Rare autosomal dominant macular disorder with an age of onset in the fourth decade. It is characterized by loss of central vision from subretinal neovascularization and atrophy of the ocular tissues. Generally, macular disciform degeneration develops in the patients eye within 6 months to 6 years. {ECO:0000269|PubMed:7550309, ECO:0000269|PubMed:7894485, ECO:0000269|PubMed:8634721, ECO:0000269|PubMed:8728699, ECO:0000269|PubMed:8981947}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Mediates a variety of processes including matrix regulation and turnover, inflammation, and angiogenesis, through reversible inhibition of zinc protease superfamily enzymes, primarily matrix metalloproteinases (MMPs). Regulates extracellular matrix (ECM) remodeling through inhibition of matrix metalloproteinases (MMP) including MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15. Additionally, modulates the processing of amyloid precursor protein (APP) and apolipoprotein E receptor ApoER2 by inhibiting two alpha-secretases ADAM10 and ADAM17 (PubMed:17913923). Functions as a tumor suppressor and a potent inhibitor of angiogenesis. Exerts its anti-angiogenic effect by directly interacting with vascular endothelial growth factor (VEGF) receptor-2/KDR, preventing its binding to the VEGFA ligand (PubMed:12652295). Selectively induces apoptosis in angiogenic endothelial cells through a caspase-independent cell death pathway (PubMed:25558000). Mechanistically, inhibits matrix-induced focal adhesion kinase PTK2 tyrosine phosphorylation and association with paxillin/PXN and disrupts the incorporation of ITGB3, PTK2 and PXN into focal adhesion contacts on the matrix (PubMed:25558000). {ECO:0000250|UniProtKB:P39876, ECO:0000269|PubMed:12652295, ECO:0000269|PubMed:17913923, ECO:0000269|PubMed:25558000}.
uniprot
proteins
mass_dalton
24145
uniprot
proteins
protein_family
Protease inhibitor I35 (TIMP) family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
12652295
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15123717
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17913923
uniprot
proteins
pubmed
18638486
uniprot
proteins
pubmed
25558000
uniprot
proteins
pubmed
7550309
uniprot
proteins
pubmed
7772252
uniprot
proteins
pubmed
7795886
uniprot
proteins
pubmed
7894485
uniprot
proteins
pubmed
8034652
uniprot
proteins
pubmed
8163205
uniprot
proteins
pubmed
8174111
uniprot
proteins
pubmed
8188246
uniprot
proteins
pubmed
8634721
uniprot
proteins
pubmed
8666262
uniprot
proteins
pubmed
8728699
uniprot
proteins
pubmed
8806658
uniprot
proteins
pubmed
8808469
uniprot
proteins
pubmed
8981947
uniprot
proteins
sequence_length
211
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
uniprot
proteins