PDCL3
entrez
79031
canonical
uniprot
Q9H2J4
canonical
ensembl
ENSG00000115539
resolver
ensp
ENSP00000264254
resolver
ensp
ENSP00000520716
resolver
enst
ENST00000264254
resolver
enst
ENST00000718278
resolver
genesymbol
PDCL3
resolver
genesymbol_syn
PhLP2A
resolver
genesymbol_syn
VIAF1
resolver
hgnc
HGNC:28860
resolver
uniprot
B2RA00
resolver
uniprot
Q53S68
resolver
uniprot_entry
PDCL3_HUMAN
resolver
uniprot_sec
B2RA00
resolver
uniprot_sec
Q53S68
resolver
amino_acid_sequence
MQDPNADTEWNDILRKKGILPPKESLKELEEEAEEEQRILQQSVVKTYEDMTLEELEDHEDEFNEEDERAIEMYRRRRLAEWKATKLKNKFGEVLEISGKDYVQEVTKAGEGLWVILHLYKQGIPLCALINQHLSGLARKFPDVKFIKAISTTCIPNYPDRNLPTIFVYLEGDIKAQFIGPLVFGGMNLTRDELEWKLSESGAIMTDLEENPKKPIEDVLLSSVRRSVLMKRDSDSEGD
uniprot
proteins
function
FUNCTION: Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:23792958, PubMed:26059764). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (PubMed:17429077). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (PubMed:15371430). {ECO:0000250|UniProtKB:Q4KLJ8, ECO:0000269|PubMed:15371430, ECO:0000269|PubMed:17429077, ECO:0000269|PubMed:23792958, ECO:0000269|PubMed:26059764}.
uniprot
proteins
mass_dalton
27614
uniprot
proteins
mutagenesis
MUTAGEN 1; /note="Missing: Loss of acetylation. Increases protein stability."; /evidence="ECO:0000269|PubMed:26059764
uniprot
proteins
post_translational_modification
PTM: N-terminal methionine acetylation destabilizes the protein. {ECO:0000269|PubMed:26059764}.
uniprot
proteins
protein_family
Phosducin family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15371430
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17429077
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19012568
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23792958
uniprot
proteins
pubmed
26059764
uniprot
proteins
sequence_length
239
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15371430, ECO:0000269|PubMed:26059764}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:26059764}. Endoplasmic reticulum {ECO:0000269|PubMed:26059764}.
uniprot
proteins