Prkx
entrez
19108
canonical
uniprot
Q922R0
canonical
ensembl
ENSMUSG00000035725
resolver
ensp
ENSMUSP00000045304
resolver
ensp
ENSMUSP00000320420
resolver
ensp
ENSMUSP00000320421
resolver
ensp
ENSMUSP00000320422
resolver
ensp
ENSMUSP00000320423
resolver
ensp
ENSMUSP00000320424
resolver
ensp
ENSMUSP00000320425
resolver
ensp
ENSMUSP00000320426
resolver
ensp
ENSMUSP00000320428
resolver
enst
ENSMUST00000036333
resolver
genesymbol
Prkx
resolver
genesymbol_syn
Pkare
resolver
uniprot
B1AVU0
resolver
uniprot
Q3UCD1
resolver
uniprot
Q8BHD6
resolver
uniprot
Q9QZ12
resolver
uniprot_entry
PRKX_MOUSE
resolver
uniprot_sec
B1AVU0
resolver
uniprot_sec
Q3UCD1
resolver
uniprot_sec
Q8BHD6
resolver
uniprot_sec
Q9QZ12
resolver
activity_regulation
ACTIVITY REGULATION: Binding of cAMP to the PRKAR1A or PRKAR1B regulatory subunits induces dissociation of the holoenzyme heterotetramer. The released monomeric PRKX is then active and able to phosphorylate its substrates (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MEPPAGAAATVKDPDHDPVKTKVSAPAADPKPRTSSQKAGHSLQDWDTIATVGTGTFGRVNLVKEKTGRQYCALKIMSIPDVIRLKQEQHVQNEKAVLKEINHPFLIKLLWTGHDNRFLYMLMEFVPGGELFTYLRNRGRFSSVASVFYATEIVCAIEYLHSKEIVYRDLKPENILLDREGHIKLTDFGFAKKLVDRTWTLCGTPEYLAPEVIQSKGHGRAVDWWALGILIFEMLSGFPPFFDDNPFGIYQKILACKIDFPRQLDFTSKDLIKKLLVVDRTRRLGNMKNGAEDIKRHRWFRGVEWESVPQRKLKPPIVPKLSGDGDISNFETYPESELDKTPSVSDKDLETFKNF
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation. {ECO:0000269|PubMed:16236808, ECO:0000269|PubMed:19367327, ECO:0000269|PubMed:21684272}.
uniprot
proteins
mass_dalton
40467
uniprot
proteins
post_translational_modification
PTM: Phosphorylated; autophosphorylates in vitro. {ECO:0000250}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
cAMP subfamily
uniprot
proteins
pubmed
10729225
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15879576
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16236808
uniprot
proteins
pubmed
19367327
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20819953
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21684272
uniprot
proteins
sequence_length
355
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=cAMP induces nuclear translocation. {ECO:0000250}.
uniprot
proteins