Socs3
entrez
12702
canonical
uniprot
O35718
canonical
ensembl
ENSMUSG00000053113
resolver
ensp
ENSMUSP00000059129
resolver
enst
ENSMUST00000054002
resolver
genesymbol
Socs3
resolver
genesymbol_syn
Cis3
resolver
genesymbol_syn
Cish3
resolver
uniprot
P97803
resolver
uniprot
Q3U7X5
resolver
uniprot_entry
SOCS3_MOUSE
resolver
uniprot_sec
P97803
resolver
uniprot_sec
Q3U7X5
resolver
amino_acid_sequence
MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVRKLQESGFYWSAVTGGEANLLLSAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCVLKLVHHYMPPPGTPSFSLPPTEPSSEVPEQPPAQALPGSTPKRAYYIYSGGEKIPLVLSRPLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGPIREFLDQYDAPL
uniprot
proteins
function
FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway (By similarity). Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including IL6ST/gp130, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors (PubMed:10821852, PubMed:12754505, PubMed:9889194). Binding to JAK2 inhibits its kinase activity and regulates IL6 signaling (PubMed:12754505, PubMed:9889194). Suppresses fetal liver erythropoiesis (PubMed:10490101). Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (PubMed:12847520). Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Upon OSM stimulation, negatively regulates the JAK-STAT signaling mediated through type II OSM receptor complex by interacting directly with JAK1 (By similarity). {ECO:0000250|UniProtKB:O14543, ECO:0000269|PubMed:10490101, ECO:0000269|PubMed:10821852, ECO:0000269|PubMed:12754505, ECO:0000269|PubMed:12847520, ECO:0000269|PubMed:9889194}.
uniprot
proteins
mass_dalton
24776
uniprot
proteins
mutagenesis
MUTAGEN 22; /note="L->A: No effect on LIF-induced signal transduction suppression."; /evidence="ECO:0000269|PubMed:10882725"; MUTAGEN 22; /note="L->D: Abolishes binding to JAK2. No effect on binding to EPOR."; /evidence="ECO:0000269|PubMed:10882725"; MUTAGEN 25; /note="F->A: Loss of LIF/EPO-induced signal transduction suppression. Abolishes binding to JAK2 and to EPOR."; /evidence="ECO:0000269|PubMed:10882725"; MUTAGEN 30; /note="E->R: No effect on LIF-induced signal transduction suppression."; MUTAGEN 45; /note="G->A: Abolishes binding to EPOR. No effect on binding to JAK2."; /evidence="ECO:0000269|PubMed:10882725"; MUTAGEN 71; /note="R->K: Little effect on LIF-induced signal transduction suppression. Loss of EPO-induced signal transduction suppression. Abolishes binding to JAK2 and EPOR."; /evidence="ECO:0000269|PubMed:10882725
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues after stimulation by the cytokines, IL-2, EPO or IGF1. {ECO:0000250}.
uniprot
proteins
pubmed
10359822
uniprot
proteins
pubmed
10490101
uniprot
proteins
pubmed
10821852
uniprot
proteins
pubmed
10882725
uniprot
proteins
pubmed
12242343
uniprot
proteins
pubmed
12754505
uniprot
proteins
pubmed
12847520
uniprot
proteins
pubmed
15213237
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16630890
uniprot
proteins
pubmed
16905102
uniprot
proteins
pubmed
23019338
uniprot
proteins
pubmed
9032278
uniprot
proteins
pubmed
9202125
uniprot
proteins
pubmed
9889194
uniprot
proteins
sequence_length
225
uniprot
proteins