Sppl2a
entrez
66552
canonical
uniprot
Q9JJF9
canonical
ensembl
ENSMUSG00000027366
resolver
ensp
ENSMUSP00000028844
resolver
enst
ENSMUST00000028844
resolver
genesymbol
Sppl2a
resolver
genesymbol_syn
Imp3
resolver
genesymbol_syn
Psl2
resolver
uniprot
A2AI51
resolver
uniprot
Q8R354
resolver
uniprot_entry
SPP2A_MOUSE
resolver
uniprot_sec
A2AI51
resolver
uniprot_sec
Q8R354
resolver
amino_acid_sequence
MGLLHSLHAPAAALLWSCLLGLAAAQEAILHASTNGVSSLSKDYCMYYNNNWTRLPSSLENATSLSLMNLTGTALCHLSDIPPDGIRNKAVVVHWGPCHFLEKARIAQEGGAAALLIANNSVLIPSSRNKSTFQNVTVLIAVITQKDFKDMKETLGDDITVKMYSPSWPNFDYTLVVIFVIAVFTVALGGYWSGLIELENMKSVEDAEDRETRKKKDDYLTFSPLTVVVFVVICCIMIVLLYFFYRWLVYVMIAIFCIASSMSLYNCLSALIHRMPCGQCTILCCGKNIKVSLIFLSGLCISVAVVWAVFRNEDRWAWILQDILGIAFCLNLIKTMKLPNFMSCVILLGLLLIYDVFFVFITPFITKNGESIMVELAAGPFENAEKLPVVIRVPKLMGYSVMSVCSVPVSVLGFGDIIVPGLLIAYCRRFDVQTGSSIYYISSTIAYAVGMIITFVVLMVMKTGQPALLYLVPCTLITVSVVAWSRKEMKKFWKGSSYQVMDHLDYSTNEENPVTTDEQIVQQ
uniprot
proteins
ec_number
3.4.23.-
uniprot
proteins
function
FUNCTION: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Functions in FASLG, ITM2B and TNF processing. Catalyzes the intramembrane cleavage of the anchored fragment of shed TNF (TNF), which promotes the release of the intracellular domain (ICD) for signaling to the nucleus. Also responsible for the intramembrane cleavage of Fas antigen ligand FASLG, which promotes the release of the intracellular FasL domain (FasL ICD). Essential for degradation of the invariant chain CD74 that plays a central role in the function of antigen-presenting cells in the immune system. Plays a role in the regulation of innate and adaptive immunity. {ECO:0000269|PubMed:30127434, ECO:0000269|PubMed:33239420}.
uniprot
proteins
mass_dalton
58129
uniprot
proteins
mutagenesis
MUTAGEN 498; /note="Y->A: Inhibits lysosomal/late endosomal targeting."; /evidence="ECO:0000269|PubMed:21896273"; MUTAGEN 506; /note="Y->A: Does not inhibit lysosomal/late endosomal targeting."; /evidence="ECO:0000269|PubMed:21896273
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:P49768}.
uniprot
proteins
protein_family
Peptidase A22B family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21896273
uniprot
proteins
pubmed
30127434
uniprot
proteins
pubmed
33239420
uniprot
proteins
sequence_length
523
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:21896273}; Multi-pass membrane protein {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:21896273}; Multi-pass membrane protein {ECO:0000305}. Membrane {ECO:0000250|UniProtKB:Q8TCT8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TCT8}; Lumenal side {ECO:0000250|UniProtKB:Q8TCT8}. Note=Colocalizes with palmitoylated and myristoylated proteins at the plasma membrane. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 176..196; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 225..245; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 248..268; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 289..309; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 316..336; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 345..365; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 404..424; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 441..461; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 464..484; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins