ASH2L
entrez
9070
canonical
uniprot
Q9UBL3
canonical
ensembl
ENSG00000129691
resolver
ensp
ENSP00000340896
resolver
ensp
ENSP00000395310
resolver
ensp
ENSP00000430259
resolver
ensp
ENSP00000443606
resolver
ensp
ENSP00000569928
resolver
ensp
ENSP00000641699
resolver
ensp
ENSP00000651091
resolver
enst
ENST00000545394
resolver
genesymbol
ASH2L
resolver
genesymbol_syn
ASH2L1
resolver
hgnc
HGNC:744
resolver
uniprot
A8K7C3
resolver
uniprot
B4DPT1
resolver
uniprot
D3DSW9
resolver
uniprot
F5H8F7
resolver
uniprot
O60659
resolver
uniprot
O60660
resolver
uniprot
Q96B62
resolver
uniprot_entry
ASH2L_HUMAN
resolver
uniprot_entry
B4DPT1_HUMAN
resolver
uniprot_entry
F5H8F7_HUMAN
resolver
uniprot_sec
A8K7C3
resolver
uniprot_sec
D3DSW9
resolver
uniprot_sec
O60659
resolver
uniprot_sec
O60660
resolver
uniprot_sec
Q96B62
resolver
amino_acid_sequence
MAAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSTSGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLKQTPHSEIIFYKNGVNQGVAYKDIFEGVYFPAISLYKSCTVSINFGPCFKYPPKDLTYRPMSDMGWGAVVEHTLADVLYHVETEVDGRRSPPWEP
uniprot
proteins
function
FUNCTION: Transcriptional regulator (PubMed:12670868). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338). Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated (PubMed:19556245). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (PubMed:19556245). May play a role in hematopoiesis (PubMed:12670868). In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). {ECO:0000269|PubMed:12670868, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:22266653}.
uniprot
proteins
mass_dalton
68723
uniprot
proteins
mutagenesis
MUTAGEN 296; /note="R->K: Abolishes methylation."; /evidence="ECO:0000269|PubMed:21285357"; MUTAGEN 300; /note="R->K: Slightly decreased methylation."; /evidence="ECO:0000269|PubMed:21285357
uniprot
proteins
post_translational_modification
PTM: Both monomethylated and dimethylated on arginine residues in the C-terminus. Arg-296 is the major site. Methylation is not required for nuclear localization, nor for MLL complex integrity or maintenance of global histone H3K4me3 levels. {ECO:0000269|PubMed:21285357}.
uniprot
proteins
pubmed
10393421
uniprot
proteins
pubmed
11466562
uniprot
proteins
pubmed
12670868
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14992727
uniprot
proteins
pubmed
15199122
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15960975
uniprot
proteins
pubmed
16253997
uniprot
proteins
pubmed
17355966
uniprot
proteins
pubmed
17500065
uniprot
proteins
pubmed
17998332
uniprot
proteins
pubmed
18838538
uniprot
proteins
pubmed
19131338
uniprot
proteins
pubmed
19556245
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21220120
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21285357
uniprot
proteins
pubmed
21660059
uniprot
proteins
pubmed
22266653
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
628
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:17355966}.
uniprot
proteins