OTUD1
entrez
220213
canonical
uniprot
Q5VV17
canonical
ensembl
ENSG00000165312
resolver
ensp
ENSP00000365678
resolver
enst
ENST00000376495
resolver
genesymbol
OTUD1
resolver
genesymbol_syn
DUBA7
resolver
genesymbol_syn
OTDC1
resolver
hgnc
HGNC:27346
resolver
uniprot_entry
OTUD1_HUMAN
resolver
amino_acid_sequence
MQLYSSVCTHYPAGAPGPTAAAPAPPAAATPFKVSLQPPGAAGAAPEPETGECQPAAAAEHREAAAVPAAKMPAFSSCFEVVSGAAAPASAAAGPPGASCKPPLPPHYTSTAQITVRALGADRLLLHGPDPVPGAAGSAAAPRGRCLLLAPAPAAPVPPRRGSSAWLLEELLRPDCPEPAGLDATREGPDRNFRLSEHRQALAAAKHRGPAATPGSPDPGPGPWGEEHLAERGPRGWERGGDRCDAPGGDAARRPDPEAEAPPAGSIEAAPSSAAEPVIVSRSDPRDEKLALYLAEVEKQDKYLRQRNKYRFHIIPDGNCLYRAVSKTVYGDQSLHRELREQTVHYIADHLDHFSPLIEGDVGEFIIAAAQDGAWAGYPELLAMGQMLNVNIHLTTGGRLESPTVSTMIHYLGPEDSLRPSIWLSWLSNGHYDAVFDHSYPNPEYDNWCKQTQVQRKRDEELAKSMAISLSKMYIEQNACS
uniprot
proteins
ec_number
3.4.19.12
uniprot
proteins
function
FUNCTION: Deubiquitinating enzyme that specifically hydrolyzes 'Lys-63'-linked polyubiquitin to monoubiquitin (PubMed:23827681). Required for the stability and translation of a subset mRNAs with a high abundance of rare codons by mediating deubiquitination of 40S ribosomal protein RPS10/eS10, thereby antagonizing ZNF598-mediated 40S ubiquitination (PubMed:36445135). The abundance of rare codons in mRNAs can limit the translation rate and can lead to ribosome collisions that trigger activation of ribosome quality control (RQC) pathway by ZNF598 (PubMed:36445135). OTUD1-mediated deubiquitination prevents activation of the RQC and subsequent dissociation of ribosomes and stimulates formation of polysomes and translation (PubMed:36445135). {ECO:0000269|PubMed:23827681, ECO:0000269|PubMed:36445135}.
uniprot
proteins
mass_dalton
51063
uniprot
proteins
mutagenesis
MUTAGEN 320; /note="C->R: Abolished deubiquitinase activity."; /evidence="ECO:0000269|PubMed:36445135
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
23827681
uniprot
proteins
pubmed
36445135
uniprot
proteins
sequence_length
481
uniprot
proteins