Rufy4
entrez
435626
canonical
uniprot
Q3TYX8
canonical
ensembl
ENSMUSG00000061815
resolver
ensp
ENSMUSP00000079062
resolver
ensp
ENSMUSP00000115873
resolver
genesymbol
Rufy4
resolver
uniprot
B2RX43
resolver
uniprot
D3YY30
resolver
uniprot_entry
RUFY4_MOUSE
resolver
uniprot_sec
B2RX43
resolver
uniprot_sec
D3YY30
resolver
amino_acid_sequence
MANNGTILKISRSLKNAVSAILQGYGDGQEPVTETSAELHRLCGCLELLLQFDQKEQRSFLGARKDYWDFLFTALRRHRGYTEQMSFICSQDKLKTSLGKGRAFIRLCLARGQLAESMQLCLLNPQLTREWYGPRSPLLCAELQEDILDSLYALNGVAFNLDLQRPDLDEAWPMFSESRCSSPSRTGKRRPGKPKGFPEEVRCSRGEQLQEPDTGGTSCLQDATREDRTPDLCKPLQPSHLPTFLEEKREDSRSLSCPQSTWETEREGFQLDQKDGGPKPRKFLENSTASIQQQRSRAKDVKMQLTGRKVEGKGSLSGTEDQRTTEGIQKRAADWDLGQGLMAPGLQGREDAELGYRCEWNQPDVLRQSWVLGTKKSSPTEKPQEWTGVTSGTMQEDGSEVPLQQEVIKDPGYGLQLAKEQAQCQEQLRAQEAELQALQEQLSRCQKERALLQVKLEQKQQEAERRDAMYQTELEGQRDLVQAMKRRVLELIHEKDLQWQRLQQLSTVAPGHCIGCNKVFRRLSRRYPCRLCGGLVCHACSVDYKKRERCCPTCAQQEEIQDT
uniprot
proteins
function
FUNCTION: ARL8 effector that promotes the coupling of endolysosomes to dynein-dynactin for retrograde transport along microtubules. Acts by binding both GTP-bound ARL8 and dynein-dynactin. In nonneuronal cells, promotes concentration of endolysosomes in the juxtanuclear area. In hippocampal neurons, drives retrograde transport of endolysosomes from the axon to the soma (By similarity). Positive regulator of macroautophagy in dendritic cells. Increases autophagic flux, probably by stimulating both autophagosome formation and facilitating tethering with lysosomes. Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through its FYVE-type zinc finger (By similarity). Positive regulator of osteoclast bone-resorbing activity, possibly by promoting late endosome-lysosome fusion by acting as an adapter protein between RAB7A on late endosomes and LAMP2 on primary lysosomes (PubMed:38744829). {ECO:0000250|UniProtKB:Q6ZNE9, ECO:0000269|PubMed:38744829}.
uniprot
proteins
mass_dalton
64036
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
26416964
uniprot
proteins
pubmed
38744829
uniprot
proteins
sequence_length
563
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:Q6ZNE9}. Lysosome {ECO:0000250|UniProtKB:Q6ZNE9}. Note=In the presence of ARL8, recruited to endolysosomes. {ECO:0000250|UniProtKB:Q6ZNE9}.
uniprot
proteins