Spib
entrez
272382
canonical
uniprot
O35906
canonical
ensembl
ENSMUSG00000008193
resolver
ensp
ENSMUSP00000035539
resolver
ensp
ENSMUSP00000096084
resolver
ensp
ENSMUSP00000145968
resolver
ensp
ENSMUSP00000256083
resolver
genesymbol
Spib
resolver
uniprot
O35907
resolver
uniprot
O35909
resolver
uniprot
O55199
resolver
uniprot_entry
SPIB_MOUSE
resolver
uniprot_sec
O35907
resolver
uniprot_sec
O35909
resolver
uniprot_sec
O55199
resolver
amino_acid_sequence
MLALEAAQLDGPHLSCLYPEGVFYDLDSCKPFSYPDSDGGLDSTWGWTEAPPAPAIAPYEAFDPATAAFSHSQTVQLCYSHGPNPSTYSPMGTLDPAPSLEAPGPGLQVYPPEDFTSQTLGSLAYAPYPSPVLSEEEDIMLDSPALEVSDSESDEALLAGSEGRGSEAGARKKLRLYQFLLGLLLRGDMRECVWWVEPGAGVFQFSSKHKELLARRWGQQKGNRKRMTYQKLARALRNYAKTGEIRKVKRKLTYQFDSALLPASRHV
uniprot
proteins
function
FUNCTION: Sequence specific transcriptional activator which binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. Promotes development of plasmacytoid dendritic cells (pDCs), also known as type 2 DC precursors (pre-DC2) or natural interferon (IFN)-producing cells. These cells have the capacity to produce large amounts of interferon and block viral replication. Required for B-cell receptor (BCR) signaling, which is necessary for normal B-cell development and antigenic stimulation. {ECO:0000269|PubMed:10229183, ECO:0000269|PubMed:11313289, ECO:0000269|PubMed:11672537, ECO:0000269|PubMed:11980719, ECO:0000269|PubMed:12431391, ECO:0000269|PubMed:8691135, ECO:0000269|PubMed:9384589}.
uniprot
proteins
mass_dalton
29365
uniprot
proteins
protein_family
ETS family
uniprot
proteins
pubmed
10229183
uniprot
proteins
pubmed
11313289
uniprot
proteins
pubmed
11672537
uniprot
proteins
pubmed
11980719
uniprot
proteins
pubmed
12431391
uniprot
proteins
pubmed
8626664
uniprot
proteins
pubmed
8691135
uniprot
proteins
pubmed
9384589
uniprot
proteins
pubmed
9511763
uniprot
proteins
sequence_length
267
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q01892}.
uniprot
proteins