Tgtp1
entrez
21822
canonical
uniprot
Q62293
canonical
ensembl
ENSMUSG00000078921
resolver
ensembl
ENSMUSG00000078922
resolver
ensp
ENSMUSP00000045025
resolver
ensp
ENSMUSP00000069914
resolver
enst
ENSMUST00000046745
resolver
enst
ENSMUST00000068063
resolver
genesymbol
Tgtp1
resolver
genesymbol_syn
Ifggb5
resolver
genesymbol_syn
Irgb6
resolver
genesymbol_syn
Mg21
resolver
uniprot
Q60711
resolver
uniprot
Q8BN19
resolver
uniprot_entry
TGTP1_MOUSE
resolver
uniprot_sec
Q60711
resolver
uniprot_sec
Q8BN19
resolver
amino_acid_sequence
MAWASSFDAFFKNFKRESKIISEYDITLIMTYIEENKLQKAVSVIEKVLRDIESAPLHIAVTGETGAGKSTFINTLRGVGHEEKGAAPTGAIETTMKRTPYPHPKLPNVTIWDLPGIGTTNFTPQNYLTEMKFGEYDFFIIISATRFKENDAQLAKAIAQMGMNFYFVRTKIDSDLDNEQKFKPKSFNKEEVLKNIKDYCSNHLQESLDSEPPVFLVSNVDISKYDFPKLETKLLQDLPAHKRHVFSLSLQSLTEATINYKRDSLKQKVFLEAMKAGALATIPLGGMISDILENLDETFNLYRSYFGLDDASLENIAQDLNMSVDDFKVHLRFPHLFAEHNDESLEDKLFKYIKHISSVTGGPVAAVTYYRMAYYLQNLFLDTAANDAIALLNSKALFEKKVGPYISEPPEYWEA
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Involved in innate cell-autonomous resistance to intracellular pathogens, such as Toxoplasma gondii (PubMed:19265156, PubMed:20109161, PubMed:24563254, PubMed:21147463). During avirulent type II T.gondii infection, recruited to the parasitophorous vacuole (PV) membrane, leading to PV vesiculation and rupture, and subsequent digestion of the parasite within the cytosol (PubMed:19265156, PubMed:24563254, PubMed:24324375, PubMed:22802726, PubMed:21147463). Not recruited to virulent type I T.gondii PV membrane (PubMed:19265156). May confer an antiviral state for vesicular stomatitis virus (PubMed:9725230). {ECO:0000269|PubMed:19265156, ECO:0000269|PubMed:20109161, ECO:0000269|PubMed:21147463, ECO:0000269|PubMed:22802726, ECO:0000269|PubMed:24324375, ECO:0000269|PubMed:24563254, ECO:0000269|PubMed:9725230}.
uniprot
proteins
mass_dalton
47121
uniprot
proteins
post_translational_modification
PTM: (Microbial infection) Phosphorylated by Toxoplasma gondii ROP17; the phosphorylation leads to disassembly of IRGB6 (TGTP1/TGTP2) polymers into monomers and dimers (PubMed:24832449). Phosphorylated by Toxoplasma gondii ROP18 (PubMed:21147463). {ECO:0000269|PubMed:21147463, ECO:0000269|PubMed:24832449}.
uniprot
proteins
protein_family
IRG family
uniprot
proteins
protein_family
TRAFAC class dynamin-like GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16277747
uniprot
proteins
pubmed
19265156
uniprot
proteins
pubmed
19285957
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20109161
uniprot
proteins
pubmed
21147463
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22761577
uniprot
proteins
pubmed
22802726
uniprot
proteins
pubmed
22892676
uniprot
proteins
pubmed
24324375
uniprot
proteins
pubmed
24563254
uniprot
proteins
pubmed
24832449
uniprot
proteins
pubmed
7836757
uniprot
proteins
pubmed
7884320
uniprot
proteins
pubmed
9725230
uniprot
proteins
sequence_length
415
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19285957}. Endoplasmic reticulum {ECO:0000269|PubMed:19285957}. Golgi apparatus {ECO:0000269|PubMed:19285957}. Note=In astrocytes stimulated with IFNG or TNF, diffuse cytoplasmic localization decreases and the protein partially relocalizes to the endoplasmic reticulum and Golgi apparatus (PubMed:19285957). Due to sequence similarity with Tgtp2, it is impossible to assign unambiguously experimental data published in the literature to Tgtp1 or Tgtp2 gene (Probable). {ECO:0000269|PubMed:19285957, ECO:0000305|PubMed:22892676}.; SUBCELLULAR LOCATION: Parasitophorous vacuole membrane; Peripheral membrane protein {ECO:0000269|PubMed:21147463, ECO:0000269|PubMed:22761577, ECO:0000269|PubMed:24324375}. Note=(Microbial infection).
uniprot
proteins