AGTR1
entrez
185
canonical
uniprot
P30556
canonical
ensembl
ENSG00000144891
resolver
ensp
ENSP00000273430
resolver
ensp
ENSP00000385612
resolver
ensp
ENSP00000385641
resolver
ensp
ENSP00000398832
resolver
ensp
ENSP00000418084
resolver
ensp
ENSP00000418851
resolver
ensp
ENSP00000419422
resolver
ensp
ENSP00000419783
resolver
ensp
ENSP00000562913
resolver
ensp
ENSP00000562914
resolver
ensp
ENSP00000562915
resolver
ensp
ENSP00000562916
resolver
ensp
ENSP00000562917
resolver
ensp
ENSP00000562918
resolver
ensp
ENSP00000562919
resolver
ensp
ENSP00000562920
resolver
ensp
ENSP00000562921
resolver
ensp
ENSP00000562922
resolver
ensp
ENSP00000562923
resolver
ensp
ENSP00000562924
resolver
ensp
ENSP00000562925
resolver
ensp
ENSP00000562926
resolver
ensp
ENSP00000562927
resolver
ensp
ENSP00000562928
resolver
ensp
ENSP00000614600
resolver
ensp
ENSP00000614601
resolver
ensp
ENSP00000614602
resolver
enst
ENST00000349243
resolver
enst
ENST00000402260
resolver
enst
ENST00000404754
resolver
enst
ENST00000418473
resolver
enst
ENST00000461609
resolver
enst
ENST00000474935
resolver
enst
ENST00000475347
resolver
enst
ENST00000497524
resolver
enst
ENST00000892854
resolver
enst
ENST00000892855
resolver
enst
ENST00000892856
resolver
enst
ENST00000892857
resolver
enst
ENST00000892858
resolver
enst
ENST00000892859
resolver
enst
ENST00000892860
resolver
enst
ENST00000892861
resolver
enst
ENST00000892862
resolver
enst
ENST00000892863
resolver
enst
ENST00000892864
resolver
enst
ENST00000892865
resolver
enst
ENST00000892866
resolver
enst
ENST00000892867
resolver
enst
ENST00000892868
resolver
enst
ENST00000892869
resolver
enst
ENST00000944541
resolver
enst
ENST00000944542
resolver
enst
ENST00000944543
resolver
genesymbol
AGTR1
resolver
genesymbol_syn
AGTR1A
resolver
genesymbol_syn
AGTR1B
resolver
genesymbol_syn
AT2R1
resolver
genesymbol_syn
AT2R1B
resolver
hgnc
HGNC:336
resolver
uniprot
A0A0A0MSE3
resolver
uniprot
A0A0A0MSP9
resolver
uniprot
D3DNG8
resolver
uniprot
D3DNG9
resolver
uniprot
Q13725
resolver
uniprot
Q53YY0
resolver
uniprot
Q6NUP5
resolver
uniprot
Q8TBK4
resolver
uniprot_entry
A0A0A0MSE3_HUMAN
resolver
uniprot_entry
AGTR1_HUMAN
resolver
uniprot_entry
D3DNG8_HUMAN
resolver
uniprot_entry
Q53YY0_HUMAN
resolver
uniprot_entry
Q6NUP5_HUMAN
resolver
uniprot_sec
A0A0A0MSP9
resolver
uniprot_sec
D3DNG9
resolver
uniprot_sec
Q13725
resolver
uniprot_sec
Q8TBK4
resolver
activity_regulation
ACTIVITY REGULATION: Strongly inhibited by anti-hypertensive drugs losartan, candesartan, valsartan, irbesartan, telmisartan, eprosartan, olmesartan and azilsartan, most of which share a common biphenyl-tetrazole scaffold. {ECO:0000269|PubMed:25913193, ECO:0000269|PubMed:26420482}.
uniprot
proteins
amino_acid_sequence
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
uniprot
proteins
disease_involvement
DISEASE: Renal tubular dysgenesis (RTD) [MIM:267430]: Autosomal recessive severe disorder of renal tubular development characterized by persistent fetal anuria and perinatal death, probably due to pulmonary hypoplasia from early-onset oligohydramnios (the Potter phenotype). {ECO:0000269|PubMed:16116425}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney (PubMed:15611106, PubMed:1567413, PubMed:25913193, PubMed:26420482, PubMed:30639100, PubMed:32079768, PubMed:8987975). The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C (PubMed:15611106). {ECO:0000269|PubMed:15611106, ECO:0000269|PubMed:1567413, ECO:0000269|PubMed:25913193, ECO:0000269|PubMed:26420482, ECO:0000269|PubMed:30639100, ECO:0000269|PubMed:32079768, ECO:0000269|PubMed:8987975}.; FUNCTION: (Microbial infection) During SARS coronavirus-2/SARS-CoV-2 infection, it is able to recognize and internalize the complex formed by secreted ACE2 and SARS-CoV-2 spike protein through DNM2/dynamin 2-dependent endocytosis. {ECO:0000269|PubMed:33713620}.
uniprot
proteins
mass_dalton
41061
uniprot
proteins
mutagenesis
MUTAGEN 35; /note="Y->A,F: Abolished binding to angiotensin II; abolished binding to olmesartan inhibitor."; /evidence="ECO:0000269|PubMed:26420482"; MUTAGEN 84; /note="W->A,I: Abolished binding to angiotensin II; abolished binding to olmesartan inhibitor."; /evidence="ECO:0000269|PubMed:25913193, ECO:0000269|PubMed:26420482"; MUTAGEN 92; /note="Y->A: Decreased binding to telmisartan inhibitor."; /evidence="ECO:0000269|PubMed:25913193"; MUTAGEN 111; /note="N->A,F,I: Reduced affinity for angiotensin II."; /evidence="ECO:0000269|PubMed:8987975"; MUTAGEN 111; /note="N->G: Induces a conformational change in the angiotensin II-binding pocket, leading to constitutive activation of the receptor."; /evidence="ECO:0000269|PubMed:8987975"; MUTAGEN 112; /note="L->A: Increased affinity for angiotensin II."; /evidence="ECO:0000269|PubMed:32079768"; MUTAGEN 135; /note="K->A: Abolished binding to angiotensin II."; /evidence="ECO:0000269|PubMed:25913193"; MUTAGEN 167; /note="R->A: Abolished binding to angiotensin II; abolished binding to olmesartan inhibitor."; /evidence="ECO:0000269|PubMed:25913193, ECO:0000269|PubMed:26420482"; MUTAGEN 182; /note="F->A: Reduced binding to angiotensin II without affecting binding to candesartan inhibitor."; /evidence="ECO:0000269|PubMed:26420482"; MUTAGEN 199; /note="K->R,Q: Abolished binding to angiotensin II."; /evidence="ECO:0000269|PubMed:26420482"; MUTAGEN 284; /note="M->A: Slightly affects binding to eprosartan inhibitor."; /evidence="ECO:0000269|PubMed:25913193"; MUTAGEN 285; /note="P->A: Decreased binding to eprosartan inhibitor."; /evidence="ECO:0000269|PubMed:25913193"; MUTAGEN 288; /note="I->A: Decreased binding to eprosartan inhibitor."; /evidence="ECO:0000269|PubMed:25913193, ECO:0000269|PubMed:26420482"; MUTAGEN 292; /note="Y->A: Mimics the disordered side chain induced by angiotensin II-binding; increased affinity for G protein subunit alpha proteins. Decreased affinity for telmisartan."; /evidence="ECO:0000269|PubMed:26420482, ECO:0000269|PubMed:32079768
uniprot
proteins
post_translational_modification
PTM: C-terminal Ser or Thr residues may be phosphorylated. {ECO:0000303|PubMed:1378723}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
1378723
uniprot
proteins
pubmed
1508224
uniprot
proteins
pubmed
1543512
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1550596
uniprot
proteins
pubmed
15611106
uniprot
proteins
pubmed
1567413
uniprot
proteins
pubmed
15809376
uniprot
proteins
pubmed
16116425
uniprot
proteins
pubmed
19139490
uniprot
proteins
pubmed
25913193
uniprot
proteins
pubmed
26420482
uniprot
proteins
pubmed
26460884
uniprot
proteins
pubmed
30639100
uniprot
proteins
pubmed
32079768
uniprot
proteins
pubmed
33713620
uniprot
proteins
pubmed
7792812
uniprot
proteins
pubmed
8135787
uniprot
proteins
pubmed
8987975
uniprot
proteins
sequence_length
359
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:33713620}; Multi-pass membrane protein {ECO:0000269|PubMed:25913193, ECO:0000269|PubMed:26420482, ECO:0000269|PubMed:30639100, ECO:0000269|PubMed:32079768}.
uniprot
proteins
transmembrane_region
TRANSMEM 26..55; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:25913193, ECO:0000269|PubMed:26420482, ECO:0000269|PubMed:30639100, ECO:0000269|PubMed:32079768, ECO:0007744|PDB:4YAY, ECO:0007744|PDB:4ZUD, ECO:0007744|PDB:6DO1, ECO:0007744|PDB:6OS0, ECO:0007744|PDB:6OS1, ECO:0007744|PDB:6OS2"; TRANSMEM 62..89; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:25913193, ECO:0000269|PubMed:26420482, ECO:0000269|PubMed:30639100, ECO:0000269|PubMed:32079768, ECO:0007744|PDB:4YAY, ECO:0007744|PDB:4ZUD, ECO:0007744|PDB:6DO1, ECO:0007744|PDB:6OS0, ECO:0007744|PDB:6OS1, ECO:0007744|PDB:6OS2"; TRANSMEM 99..125; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:25913193, ECO:0000269|PubMed:26420482, ECO:0000269|PubMed:30639100, ECO:0000269|PubMed:32079768, ECO:0007744|PDB:4YAY, ECO:0007744|PDB:4ZUD, ECO:0007744|PDB:6DO1, ECO:0007744|PDB:6OS0, ECO:0007744|PDB:6OS1, ECO:0007744|PDB:6OS2"; TRANSMEM 142..165; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:25913193, ECO:0000269|PubMed:26420482, ECO:0000269|PubMed:30639100, ECO:0000269|PubMed:32079768, ECO:0007744|PDB:4YAY, ECO:0007744|PDB:4ZUD, ECO:0007744|PDB:6DO1, ECO:0007744|PDB:6OS0, ECO:0007744|PDB:6OS1, ECO:0007744|PDB:6OS2"; TRANSMEM 191..216; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:25913193, ECO:0000269|PubMed:26420482, ECO:0000269|PubMed:30639100, ECO:0000269|PubMed:32079768, ECO:0007744|PDB:4YAY, ECO:0007744|PDB:4ZUD, ECO:0007744|PDB:6DO1, ECO:0007744|PDB:6OS0, ECO:0007744|PDB:6OS1, ECO:0007744|PDB:6OS2"; TRANSMEM 240..268; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:25913193, ECO:0000269|PubMed:26420482, ECO:0007744|PDB:4YAY, ECO:0007744|PDB:4ZUD"; TRANSMEM 279..304; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:25913193, ECO:0000269|PubMed:26420482, ECO:0007744|PDB:4YAY, ECO:0007744|PDB:4ZUD
uniprot
proteins