Sptssa
entrez
500651
canonical
uniprot
Q4G019
canonical
ensembl
ENSRNOG00000004292
resolver
ensembl
ENSRNOG00055013504
resolver
ensembl
ENSRNOG00060021422
resolver
ensembl
ENSRNOG00065005034
resolver
ensp
ENSRNOP00000005825
resolver
ensp
ENSRNOP00055018790
resolver
ensp
ENSRNOP00060030592
resolver
ensp
ENSRNOP00065005122
resolver
enst
ENSRNOT00000005825
resolver
enst
ENSRNOT00055023151
resolver
enst
ENSRNOT00060037086
resolver
enst
ENSRNOT00065007371
resolver
genesymbol
Sptssa
resolver
genesymbol_syn
Ssspta
resolver
uniprot_entry
SPTSA_RAT
resolver
amino_acid_sequence
MAGMALARAWKQMSWFYYQYLLVTALYMLEPWERTVFNSMLVSVVGMALYTGYVFMPQHIMAILHYFEIVQ
uniprot
proteins
function
FUNCTION: Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is composed of SPTLC1, SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer consisting of SPTLC1 and SPTLC2/SPTLC3 forms the catalytic core. Within the SPT complex, SPTSSA stimulates the catalytic activity and plays a role in substrate specificity, which depends upon the overall complex composition. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. Independently of its action as a SPT component, may be involved in MBOAT7 localization to mitochondria-associated membranes, a membrane bridge between the endoplasmic reticulum and mitochondria, may hence affect MBOAT7-catalyzed incorporation of arachidonic acid into phosphatidylinositol. {ECO:0000250|UniProtKB:Q969W0}.
uniprot
proteins
mass_dalton
8452
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; sphingolipid metabolism.
uniprot
proteins
protein_family
SPTSS family
uniprot
proteins
protein_family
SPTSSA subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
71
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 35..57; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins