Gas2l2
entrez
237891
canonical
uniprot
Q5SSG4
canonical
ensembl
ENSMUSG00000020686
resolver
ensp
ENSMUSP00000051907
resolver
enst
ENSMUST00000052521
resolver
genesymbol
Gas2l2
resolver
uniprot
B9EJR3
resolver
uniprot_entry
GA2L2_MOUSE
resolver
uniprot_sec
B9EJR3
resolver
amino_acid_sequence
MSQHVGHGRRPRTPGPPVRSIRPFKSSEQYLEAMKEDLAEWLRDLYGLDIDADNFLRVLETGLVLCRHANTVTEAALAFLAEAPERAQKIPMPQAGVFCNGAAQPGTFQARDNISNFIQWCRKEMGIQEVLMFETEDLVLRKNVKSVVLCLLELGRRAWRFGVAAPALVHLEEEIDEELRRDLALPSPDPPPPIPPARRPCHFHNLDQMVQSLVSHCTCPVQFSMVKISEGKYRVGDSNTLIFIRILRSHVMVRVGGGWDTLGHYLDKHDPCRCTSLSHKPGSFLKPPGPPVQHEVKVQDGPSQPQPTMTISRSQSPLPPVDWKTYTSSSRKLRPPTPSSPGLRSEPPVRARTLREDPLPRSQEKPTPSQRMSSPGPQFSSTCRGPDLQSTLSGKRANRCPGEPPRGRTPTLWVHKEAGSRGTHTKAPTPQRLQIPEATSKRTSARGPSPPPRSSSLASPHMIWVLHQGASPQLSEPMTVHSSSPGKGLTKIPIRLSPARPPTPGRSSLGTEGEYSTGRGSISSRALEGNLDRSTHGHHSVEASGDHQTDIQTTSETEDPRSLGTQKWKERHTSLALGRRREQALYDNLKEEVVANMKLLEVGTAYTQGTRSQAIPRSGVYVPSLGGRWPEPGGPYDKVIRELVQGPPPLLKVDLKAWKVGSECLPRPIVDPGSPKEKLGSRETGTRIKASLNAEDTTVRTVSPARGQGCSTPPVSANLEAPTRSCSDPSSDKASVCLGKGKRTLRKPQKIPSIYKLKLRPRIRPRRDHRPEKRPSRIPKPLPYSCLVLARTAPGSRLLKATLGGKGGVPCQVNGTGKKEEEKKKGGSNISLESSIQPAESQEPLKLGGTPLSPEEESWV
uniprot
proteins
function
FUNCTION: Involved in the cross-linking of microtubules and microfilaments (By similarity). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (By similarity). Enhances ADORA2-mediated adenylyl cyclase activation by acting as a scaffold to recruit trimeric G protein complexes to ADORA2A (PubMed:23994616). Regulates ciliary orientation and performance in cells located in the airway (PubMed:30665704). {ECO:0000250|UniProtKB:Q8NHY3, ECO:0000269|PubMed:23994616, ECO:0000269|PubMed:30665704}.
uniprot
proteins
mass_dalton
94318
uniprot
proteins
protein_family
GAS2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23994616
uniprot
proteins
pubmed
24706950
uniprot
proteins
pubmed
30665704
uniprot
proteins
sequence_length
860
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23994616}. Cell membrane {ECO:0000269|PubMed:23994616}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:Q8NHY3}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:30665704}. Note=Colocalizes with ADORA2A at neuronal processes (By similarity). Colocalizes with and tracks the tips of microtubule plus ends (By similarity). {ECO:0000250|UniProtKB:D3ZUE1, ECO:0000250|UniProtKB:Q8NHY3}.
uniprot
proteins