Auh
entrez
361215
canonical
uniprot
F1LU71
canonical
ensembl
ENSRNOG00000011684
resolver
ensembl
ENSRNOG00055015556
resolver
ensembl
ENSRNOG00060018132
resolver
ensembl
ENSRNOG00065010094
resolver
ensp
ENSRNOP00000015786
resolver
ensp
ENSRNOP00000090436
resolver
ensp
ENSRNOP00055021551
resolver
ensp
ENSRNOP00060025337
resolver
ensp
ENSRNOP00065012329
resolver
enst
ENSRNOT00000015786
resolver
enst
ENSRNOT00000096716
resolver
enst
ENSRNOT00055026562
resolver
enst
ENSRNOT00060031240
resolver
enst
ENSRNOT00065016269
resolver
genesymbol
Auh
resolver
uniprot
A0A8I6AAT9
resolver
uniprot_entry
A0A8I6AAT9_RAT
resolver
uniprot_entry
AUHM_RAT
resolver
amino_acid_sequence
MAAAAAPGALGALSAGRVRLVAACCARLGSAAWARGTAPRRGYSSEVKTEDELRVRHLEEENRGIVVLGINRAYGKNSLSKNLLKMLSKAVDALKSDKKVRTIIIRSEVPGIFCAGADLKERAKMHSSEVGPFVSKIRAVINDIANLPVPTIAAIDGLALGGGLELALACDIRVAASSAKMGLVETKLAIIPGGGGTQRLPRAIGMALAKELIFSARVLDGQEAKAVGLISHVLEQNQEGDAAYRKALDLAREFLPQGPVAMRVAKLAINQGMEVDLVTGLAIEEACYAQTISTKDRLEGLLAFKEKRPPRYKGE
uniprot
proteins
ec_number
4.2.1.18
uniprot
proteins
ec_number
4.2.1.56
uniprot
proteins
function
FUNCTION: Catalyzes the fifth step in the leucine degradation pathway, the reversible hydration of 3-methylglutaconyl-CoA (3-MG-CoA) to 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). Can catalyze the reverse reaction but at a much lower rate in vitro. HMG-CoA is then quickly degraded by another enzyme (such as HMG-CoA lyase) to give acetyl-CoA and acetoacetate. Uses other substrates such as (2E)-glutaconyl-CoA efficiently in vitro, and to a lesser extent 3-methylcrotonyl-CoA (3-methyl-(2E)-butenoyl-CoA), crotonyl-CoA ((2E)-butenoyl-CoA) and 3-hydroxybutanoyl-CoA (the missing carboxylate reduces affinity to the active site). Originally it was identified as an RNA-binding protein as it binds to AU-rich elements (AREs) in vitro. AREs direct rapid RNA degradation and mRNA deadenylation (By similarity). Might have itaconyl-CoA hydratase activity, converting itaconyl-CoA into citramalyl-CoA in the C5-dicarboxylate catabolism pathway. The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, an antimicrobial metabolite and immunomodulator produced by macrophages during certain infections, that can act as a vitamin B12-poisoning metabolite (PubMed:13783048). {ECO:0000250|UniProtKB:Q13825, ECO:0000303|PubMed:13783048}.
uniprot
proteins
mass_dalton
33341
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 3/3. {ECO:0000250|UniProtKB:Q13825}.
uniprot
proteins
protein_family
Enoyl-CoA hydratase/isomerase family
uniprot
proteins
pubmed
13783048
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
315
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9JLZ3}.
uniprot
proteins