Mknk2
entrez
299618
canonical
uniprot
Q5U2N4
canonical
ensembl
ENSRNOG00000029028
resolver
ensembl
ENSRNOG00055031813
resolver
ensembl
ENSRNOG00060028286
resolver
ensembl
ENSRNOG00065018329
resolver
ensp
ENSRNOP00000039672
resolver
ensp
ENSRNOP00000108798
resolver
ensp
ENSRNOP00055045506
resolver
ensp
ENSRNOP00060041096
resolver
ensp
ENSRNOP00065024481
resolver
enst
ENSRNOT00000140938
resolver
enst
ENSRNOT00055055061
resolver
enst
ENSRNOT00060049239
resolver
enst
ENSRNOT00065030769
resolver
genesymbol
Mknk2
resolver
uniprot_entry
MKNK2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by CGP57380 and staurosporine. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MVQKRTAELQGFHRSFKGQNPFELAFTLDPAQHGDSDFSPQCEARPDMPSSQPIDIPDAKKRGRKKKRCRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCVNLITNQEYAVKIIEKQLGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHRRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGHCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWSHISFAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTLPTPLVLQRNSCAKDLTSFAAEAIAMNRQLAQCEEDAGQDQPVLIRATSRCLQLSPPSQSKLAQRRQRASLSATPVVLVGDRV
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Enhances the formation of EIF4F complex in pachytene spermatocytes, thus promoting mRNA translation during spermatogenesis. Displays a high basal kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
51574
uniprot
proteins
post_translational_modification
PTM: Dual phosphorylation of Thr-244 and Thr-249 activates the kinase. Phosphorylation of Thr-379 activates the kinase. Phosphorylated upon arsenic trioxide As(2)O(3) treatment. Phosphorylated by MAPK1/ERK2, MAPK11 and MAPK14. Dephosphorylated by PP2A (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
459
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, PML body {ECO:0000250}.
uniprot
proteins