EDG2
entrez
1902
canonical
uniprot
Q92633
canonical
ensembl
ENSG00000198121
resolver
ensp
ENSP00000351755
resolver
ensp
ENSP00000363552
resolver
ensp
ENSP00000363553
resolver
ensp
ENSP00000506912
resolver
ensp
ENSP00000523493
resolver
ensp
ENSP00000523494
resolver
ensp
ENSP00000523495
resolver
ensp
ENSP00000523496
resolver
ensp
ENSP00000523497
resolver
ensp
ENSP00000523498
resolver
ensp
ENSP00000523499
resolver
ensp
ENSP00000523500
resolver
ensp
ENSP00000523501
resolver
ensp
ENSP00000523502
resolver
ensp
ENSP00000523504
resolver
ensp
ENSP00000523505
resolver
ensp
ENSP00000523506
resolver
ensp
ENSP00000523508
resolver
ensp
ENSP00000523509
resolver
ensp
ENSP00000523515
resolver
ensp
ENSP00000523517
resolver
ensp
ENSP00000635626
resolver
ensp
ENSP00000635630
resolver
ensp
ENSP00000776425
resolver
ensp
ENSP00000776426
resolver
genesymbol
EDG2
resolver
genesymbol
LPAR1
resolver
genesymbol_syn
EDG2
resolver
genesymbol_syn
LPA1
resolver
hgnc
HGNC:3166
resolver
uniprot
B4DK36
resolver
uniprot
O00656
resolver
uniprot
O00722
resolver
uniprot
P78351
resolver
uniprot
Q5VZX0
resolver
uniprot
Q6GPG7
resolver
uniprot_entry
LPAR1_HUMAN
resolver
uniprot_entry
Q5VZX0_HUMAN
resolver
uniprot_entry
Q6GPG7_HUMAN
resolver
uniprot_sec
B4DK36
resolver
uniprot_sec
O00656
resolver
uniprot_sec
O00722
resolver
uniprot_sec
P78351
resolver
amino_acid_sequence
MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTPGLVLLLLDVCCPQCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRSENPTGPTEGSDRSASSLNHTILAGVHSNDHSVV
uniprot
proteins
function
FUNCTION: Receptor for lysophosphatidic acid (LPA) (PubMed:19306925, PubMed:25025571, PubMed:26091040, PubMed:9070858). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as LPA receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to LPA (By similarity). Inhibits the intracellular ciliogenesis pathway in response to LPA and through AKT1 activation (PubMed:31204173). Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity). {ECO:0000250|UniProtKB:P61793, ECO:0000269|PubMed:18066075, ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:19656035, ECO:0000269|PubMed:19733258, ECO:0000269|PubMed:25025571, ECO:0000269|PubMed:26091040, ECO:0000269|PubMed:31204173, ECO:0000269|PubMed:9070858, ECO:0000305|PubMed:11093753, ECO:0000305|PubMed:9069262}.
uniprot
proteins
mass_dalton
41109
uniprot
proteins
mutagenesis
MUTAGEN 85; /note="Y->A: Impairs localization at the cell membrane."; /evidence="ECO:0000269|PubMed:25025571"; MUTAGEN 87; /note="L->A: Impairs localization at the cell membrane."; /evidence="ECO:0000269|PubMed:25025571"; MUTAGEN 325..326; /note="IL->AA: Impairs localization at the cell membrane."; /evidence="ECO:0000269|PubMed:25025571
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:25025571}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11093753
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18066075
uniprot
proteins
pubmed
19306925
uniprot
proteins
pubmed
19656035
uniprot
proteins
pubmed
19733258
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25025571
uniprot
proteins
pubmed
25732591
uniprot
proteins
pubmed
26091040
uniprot
proteins
pubmed
31204173
uniprot
proteins
pubmed
9069262
uniprot
proteins
pubmed
9070858
uniprot
proteins
sequence_length
364
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell surface {ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:25025571}. Cell membrane {ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:25025571, ECO:0000269|PubMed:26091040, ECO:0000269|PubMed:9070858}; Multi-pass membrane protein {ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:26091040}. Endosome {ECO:0000269|PubMed:19306925}. Note=Prior to LPA treatment found predominantly at the cell surface. Internalized after LPA treatment. Colocalizes with RALA in endocytic vesicles after LPA treatment. {ECO:0000269|PubMed:19306925}.
uniprot
proteins
transmembrane_region
TRANSMEM 51..75; /note="Helical; Name=1"; TRANSMEM 84..107; /note="Helical; Name=2"; TRANSMEM 122..144; /note="Helical; Name=3"; TRANSMEM 164..184; /note="Helical; Name=4"; TRANSMEM 205..225; /note="Helical; Name=5"; TRANSMEM 256..280; /note="Helical; Name=6"; TRANSMEM 295..315; /note="Helical; Name=7
uniprot
proteins