Lemd2
entrez
224640
canonical
uniprot
Q6DVA0
canonical
ensembl
ENSMUSG00000044857
resolver
ensp
ENSMUSP00000058221
resolver
enst
ENSMUST00000055117
resolver
genesymbol
Lemd2
resolver
genesymbol_syn
Lem2
resolver
uniprot
Q8C4H8
resolver
uniprot
Q8R0N2
resolver
uniprot_entry
LEMD2_MOUSE
resolver
uniprot_sec
Q8C4H8
resolver
uniprot_sec
Q8R0N2
resolver
amino_acid_sequence
MAGLSDLELRRELQALGFQPGPITDTTRNVYRNKLRRLRGEARLRDDERLREDAGPREDAGPRGPERQREEARLREEAPLRARPAASVLRSEPWPLSPSPPAPSAASDASGPYGNFGASASPWAASRGLSYPPHAGPGPLRRRASVRGSSEDDEDTRTPDRHAPGRGRHWWAPPSASARPHSALLGADARPGLKGSRTGSAGAGRTRPEVGRWLERCLSRLLLWASLGLLLGFLAILWVKMGKPSAPQEAEDNMKLLPVDCERKTDEFCQAKQKAALLELLHELYNFLAIQAGNFECGNPEKLKSKCIPVLEAQEYIANVTSSPSSRFKAALTWILSSNKDVGIWLKGEDPSELATTVDKVVCLESARPRMGIGCRLSRALLTAVTHVLIFFWCLAFLWGLLILLKYRWRKLEEEEQAMYEMVKKIIDVVQDHYVDWEQDMERYPYVGILHVRDSLIPPQSRRRMKRVWDRAVEFLASNESRIQTESHRVAGEDMLVWRWTKPSSFSDSER
uniprot
proteins
function
FUNCTION: Nuclear lamina-associated inner nuclear membrane protein that is involved in nuclear structure organization and maintenance of nuclear envelope (NE) integrity and NE reformation after mitosis (PubMed:16339967). Plays a role as transmembrane adapter for the endosomal sorting complexes required for transport (ESCRT), and is thereby involved in ESCRT-mediated NE reformation (By similarity). Promotes ESCRT-mediated NE closure by recruiting CHMP7 and downstream ESCRT-III proteins IST1/CHMP8 and CHMP2A to the reforming NE during anaphase (By similarity). During nuclear reassembly, condenses into a liquid-like coating around microtubule spindles and coassembles with CHMP7 to form a macromolecular O-ring seal at the confluence between membranes, chromatin, and the spindle to facilitate early nuclear sealing (By similarity). Plays a role in the organization of heterochromatin associated with the NE and in the maintenance of NE organization under mechanical stress (PubMed:36377660). Required for embryonic development and is involved in regulation of several signaling pathways such as MAPK and AKT (PubMed:25790465). Required for myoblast differentiation involving regulation of ERK signaling (PubMed:17062158, PubMed:19720741). Essential for cardiac homeostasis and proper heart function (PubMed:36377660). {ECO:0000250|UniProtKB:Q8NC56, ECO:0000269|PubMed:16339967, ECO:0000269|PubMed:17062158, ECO:0000269|PubMed:19720741, ECO:0000269|PubMed:25790465, ECO:0000269|PubMed:36377660}.
uniprot
proteins
mass_dalton
57507
uniprot
proteins
mutagenesis
MUTAGEN 13; /note="L->R: Reduced Lemd2 protein levels. Disorganization of heterochromatin associated with the nuclear envelope in cardiomyocytes. Increased DNA double-strand breaks in the heart. Dilation of the atrial and ventricular chambers, severe systolic dysfunction and cardiac fibrosis leading to premature death. No defects in skeletal muscle observed."; /evidence="ECO:0000269|PubMed:36377660
uniprot
proteins
post_translational_modification
PTM: Phosphorylated; strongly phosphorylated in mitosis compared to G1/S. {ECO:0000250|UniProtKB:Q8NC56}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16339967
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17062158
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19720741
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25790465
uniprot
proteins
pubmed
36377660
uniprot
proteins
sequence_length
511
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000269|PubMed:16339967, ECO:0000269|PubMed:17062158}; Multi-pass membrane protein {ECO:0000269|PubMed:16339967}. Nucleus envelope {ECO:0000269|PubMed:36377660}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q8NC56}. Note=Lamina-associated protein residing in the inner nuclear membrane (INM) of the nuclear envelope (NE) (PubMed:16339967). The localization to the INM is dependent on LMNA (By similarity). Evenly distributed around the NE during interphase (PubMed:16339967). During metaphase, found in a reticular network (By similarity). Recruited to the reforming NE on chromatin disks in early anaphase (By similarity). In late anaphase, concentrates at the NE core proximal to spindle microtubules, and then broadening to a distributed nuclear rim pattern (By similarity). {ECO:0000250|UniProtKB:Q8NC56, ECO:0000269|PubMed:16339967}.
uniprot
proteins
transmembrane_region
TRANSMEM 221..241; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 385..405; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins