Sorcs3
entrez
66673
canonical
uniprot
Q8VI51
canonical
ensembl
ENSMUSG00000063434
resolver
ensp
ENSMUSP00000077919
resolver
enst
ENSMUST00000078880
resolver
genesymbol
Sorcs3
resolver
uniprot
Q1HL22
resolver
uniprot
Q9CTR4
resolver
uniprot_entry
Q1HL22_MOUSE
resolver
uniprot_entry
SORC3_MOUSE
resolver
uniprot_sec
Q9CTR4
resolver
amino_acid_sequence
MEAAGTERPAGWPGAPLARTGLLLLSTWVLAGAEITWGATGGPGRLVSPASRPPVLPPLLPRAAENRWPEELASARRAAAPRRRSRLEPLSQASRGEIRTEAAGMSPEGARWVPGIPSPSQAGSARRTRRAQPPSPLERGDSWATALADGAKGSRPHTKGSREEVRATRTGGASTEELRLPSTSFALTGDSAHNQAMVHWSGHNSSVILILTKLYDFNLGSVTESSLWRSVDYGATYEKLNDKVGLKTVLSYLYVNPTNKRKIMLLSDPEMESSVLISSDEGATYQKYRLTFYIQSLLFHPKQEDWVLAYSLDQKLYSSMDFGRRWQLMHERITPNRFYWSVSGLDKEADLVHMEVRTADGYAHYLTCRIQECAETTRSGPFARSIDISSLVVQDEYIFIQVTIGGRASYYVSYRREAFAQIKLPKYSLPKDMHIISTDENQVFAAVQEWNQNDTYNLYISDTRGIYFTLAMENIKSSRGLMGNIIIELYEVAGIKGIFLANKKVDDQVKTYITYNKGRDWRLLQAPDVDLRGSPVHCLLPFCSLHLHLQLSENPYSSGRISSKDTAPGLVVATGNIGSELSYTDIGVFISSDGGNTWRQIFDEEYNVWFLDWGGALVAMKHTPLPVRHLWVSFDEGHSWDKYGFTLLPLFVDGALVEAGVETHIMTVFGHFSLRSEWQLVKVDYKSIFSRRCTKEDFETWHLLNQGEPCVMGERKIFKKRKPGAQCALGREYSGSVVSEPCVCADWDFECDYGYERHGESQCVPAFWYNPASPSKDCSLGQSYLNSTGYRRIVSNNCTDGLRDKYSAKTQLCPGKAPRGLHVVTTDGRLVAEQGHNATFIILMEEGDLQRTNIQLDFGDGVAVSYANFSPIEDGIRHVYKSAGIFQVTAYAENNLGSDTAFLFLHVVCPVEHVHLRVPFVAIRNKDVNISAVVWPSQLGTLTYFWWFGNSTKPLITLDSSISFTFLAEGTNTITVQVAAGNALIQDTKEIAVHEYFQSQLLSFSPNLDYHNPDIPEWRQDIGNVIKRALIKVTSVPEDQILVAVFPGLPTSAELFILPPKNLTERRKGHEGDLEQIVETLFNALNQNLVQFELKPGVQVIVYVTQLTLAPLVDSSAGHSSSAMLMLLSVVFVGLAVFLIYKFKRKIPWINIYAQVQHDKEQEMIGSVSQSENAPKITLSDFTEPEELLDKELDTRVIGSIATIASSESTKEIPNCTSV
uniprot
proteins
function
FUNCTION: Plays an important role in modulating synaptic transmission and plasticity in the hippocampus, probably by affecting the trafficking and localization of AMPA-type glutamate receptors in the postsynaptic density. {ECO:0000269|PubMed:24069373, ECO:0000269|PubMed:27935149}.
uniprot
proteins
mass_dalton
135985
uniprot
proteins
protein_family
SORCS subfamily
uniprot
proteins
protein_family
VPS10-related sortilin family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24069373
uniprot
proteins
pubmed
27935149
uniprot
proteins
sequence_length
1219
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24069373}; Single-pass type I membrane protein {ECO:0000255}. Synaptic cell membrane {ECO:0000269|PubMed:24069373}; Single-pass type I membrane protein {ECO:0000255}. Postsynaptic density {ECO:0000269|PubMed:24069373}.
uniprot
proteins
transmembrane_region
TRANSMEM 1123..1143; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins