PPP1R3C
entrez
5507
canonical
uniprot
Q9UQK1
canonical
ensembl
ENSG00000119938
resolver
ensp
ENSP00000238994
resolver
enst
ENST00000238994
resolver
genesymbol
PPP1R3C
resolver
genesymbol_syn
PPP1R5
resolver
hgnc
HGNC:9293
resolver
uniprot
B2R7X0
resolver
uniprot
O95686
resolver
uniprot_entry
PPR3C_HUMAN
resolver
uniprot_sec
B2R7X0
resolver
uniprot_sec
O95686
resolver
amino_acid_sequence
MSCTRMIQVLDPRPLTSSVMPVDVAMRLCLAHSPPVKSFLGPYDEFQRRHFVNKLKPLKSCLNIKHKAKSQNDWKCSHNQAKKRVVFADSKGLSLTAIHVFSDLPEEPAWDLQFDLLDLNDISSALKHHEEKNLILDFPQPSTDYLSFRSHFQKNFVCLENCSLQERTVTGTVKVKNVSFEKKVQIRITFDSWKNYTDVDCVYMKNVYGGTDSDTFSFAIDLPPVIPTEQKIEFCISYHANGQVFWDNNDGQNYRIVHVQWKPDGVQTQMAPQDCAFHQTSPKTELESTIFGSPRLASGLFPEWQSWGRMENLASYR
uniprot
proteins
function
FUNCTION: Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types. {ECO:0000250|UniProtKB:Q7TMB3, ECO:0000269|PubMed:8985175}.
uniprot
proteins
mass_dalton
36445
uniprot
proteins
mutagenesis
MUTAGEN 85; /note="V->A: No effect on interaction with EPM2A; when associated with A-87."; /evidence="ECO:0000269|PubMed:14532330"; MUTAGEN 87; /note="F->A: No effect on interaction with EPM2A; when associated with A-85."; /evidence="ECO:0000269|PubMed:14532330"; MUTAGEN 247; /note="D->A: No interaction with EPM2A; when associated with A-250."; /evidence="ECO:0000269|PubMed:14532330"; MUTAGEN 250; /note="D->A: No interaction with EPM2A; when associated with A-247."; /evidence="ECO:0000269|PubMed:14532330
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by NHLRC1/malin in a EPM2A/laforin-dependent manner. {ECO:0000269|PubMed:18070875}.
uniprot
proteins
pubmed
10222257
uniprot
proteins
pubmed
14532330
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18070875
uniprot
proteins
pubmed
21738631
uniprot
proteins
pubmed
8985175
uniprot
proteins
sequence_length
317
uniprot
proteins