Trmt10c
entrez
52575
canonical
uniprot
Q3UFY8
canonical
ensembl
ENSMUSG00000044763
resolver
ensp
ENSMUSP00000058954
resolver
enst
ENSMUST00000059052
resolver
genesymbol
Trmt10c
resolver
genesymbol_syn
Mrpp1
resolver
genesymbol_syn
Rg9mtd1
resolver
uniprot
Q8R588
resolver
uniprot
Q9DBC1
resolver
uniprot_entry
TM10C_MOUSE
resolver
uniprot_sec
Q8R588
resolver
uniprot_sec
Q9DBC1
resolver
amino_acid_sequence
MNVTVRFLRPFARCLVPYTFHRKRSHLYSGVLQRYMSSKAPSLSCHNKDSASPPEQLELDGWKATMKSSIQEDGVSEVSDKDEDSLASTRELIEMWRLLGKEVPEHITEEDLKTLMECASKSAKKKYLRYLYGKEKAKKAKQVKKEMKAEAREEAKRARLLETTAEEQQQDFMFLRLWDRQINIALGWKGVQAMQFGQPLVFDMAYDNYMKPSELQNTVSQLLESEGWNRRNVDPFHIYFCNLKIDSAYHRELVKRYREKWDKLLLTATEKSPVDLFPKDSIIYLTADSPNVMTTFKHDKIYIIGSFVDKNTQTGTSLAKAKRLNIATECLPLDKYLQWEIGNKNLTLDQMIRILLCLKNTGNWEEALKFVPRRKHTGYLEVSEQSQELVRKLKKTKTLNSFRKGSLNVRTWKR
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
ec_number
2.1.1.218
uniprot
proteins
ec_number
2.1.1.221
uniprot
proteins
function
FUNCTION: Mitochondrial tRNA N(1)-methyltransferase involved in mitochondrial tRNA maturation. Component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and PRORP/MRPP3, which cleaves tRNA molecules in their 5'-ends. Together with HSD17B10/MRPP2, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity. The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; TRMT10C/MRPP1 acting as the catalytic N(1)-methyltransferase subunit. The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme. In addition to tRNA N(1)-methyltransferase activity, TRMT10C/MRPP1 also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly. {ECO:0000250|UniProtKB:Q7L0Y3}.
uniprot
proteins
mass_dalton
48386
uniprot
proteins
protein_family
Class IV-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
TRM10 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
414
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250|UniProtKB:Q7L0Y3}.
uniprot
proteins