Serpinb1a
entrez
66222
canonical
uniprot
Q9D154
canonical
ensembl
ENSMUSG00000044734
resolver
ensp
ENSMUSP00000075690
resolver
enst
ENSMUST00000076352
resolver
genesymbol
Serpinb1a
resolver
genesymbol_syn
Serpinb1
resolver
uniprot
Q3TV23
resolver
uniprot
Q5SUV7
resolver
uniprot
Q9D0S8
resolver
uniprot
Q9D7S8
resolver
uniprot_entry
ILEUA_MOUSE
resolver
uniprot_sec
Q3TV23
resolver
uniprot_sec
Q5SUV7
resolver
uniprot_sec
Q9D0S8
resolver
uniprot_sec
Q9D7S8
resolver
amino_acid_sequence
MEQLSSANTLFALELFQTLNESSPTGNIFFSPFSISSALAMVILGAKGSTAAQLSKTFHFDSVEDIHSRFQSLNAEVSKRGASHTLKLANRLYGEKTYNFLPEYLASTQKMYGADLAPVDFLHASEDARKEINQWVKGQTEGKIPELLSVGVVDSMTKLVLVNAIYFKGMWEEKFMTEDTTDAPFRLSKKDTKTVKMMYQKKKFPFGYISDLKCKVLEMPYQGGELSMVILLPKDIEDESTGLKKIEKQITLEKLLEWTKRENLEFIDVHVKLPRFKIEESYTLNSNLGRLGVQDLFSSSKADLSGMSGSRDLFISKIVHKSFVEVNEEGTEAAAATGGIATFCMLLPEEEFTVDHPFIFFIRHNPTSNVLFLGRVCSP
uniprot
proteins
function
FUNCTION: Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis (PubMed:17664292, PubMed:21248149, PubMed:21683252, PubMed:30692621). Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection (PubMed:17664292). These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Also acts as a potent intracellular inhibitor of granzyme H (PubMed:12189154). During inflammation, limits the activity of inflammatory caspases CASP1 and CASP4 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation (PubMed:30692621). In addition, promotes the proliferation of beta-cells when secreted (PubMed:26701651). {ECO:0000269|PubMed:12189154, ECO:0000269|PubMed:17664292, ECO:0000269|PubMed:21248149, ECO:0000269|PubMed:21683252, ECO:0000269|PubMed:26701651, ECO:0000269|PubMed:30692621}.
uniprot
proteins
mass_dalton
42575
uniprot
proteins
protein_family
Ov-serpin subfamily
uniprot
proteins
protein_family
Serpin family
uniprot
proteins
pubmed
11863365
uniprot
proteins
pubmed
12189154
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17664292
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21248149
uniprot
proteins
pubmed
21683252
uniprot
proteins
pubmed
26701651
uniprot
proteins
pubmed
30692621
uniprot
proteins
sequence_length
379
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:26701651}. Cytoplasm {ECO:0000250|UniProtKB:P30740}. Cytolytic granule {ECO:0000250|UniProtKB:P30740}. Early endosome {ECO:0000250|UniProtKB:P30740}.
uniprot
proteins