SCG5
entrez
6447
canonical
uniprot
P05408
canonical
ensembl
ENSG00000166922
resolver
ensembl
ENSG00000277614
resolver
ensembl
ENSG00000281931
resolver
ensp
ENSP00000300175
resolver
ensp
ENSP00000388560
resolver
ensp
ENSP00000418430
resolver
ensp
ENSP00000420347
resolver
ensp
ENSP00000488565
resolver
ensp
ENSP00000488899
resolver
enst
ENST00000494364
resolver
enst
ENST00000497208
resolver
enst
ENST00000632955
resolver
enst
ENST00000633420
resolver
genesymbol
SCG5
resolver
genesymbol_syn
SGNE1
resolver
hgnc
HGNC:10816
resolver
uniprot
C9J650
resolver
uniprot
C9JNY7
resolver
uniprot
P01164
resolver
uniprot
Q6FHD0
resolver
uniprot
Q9BS38
resolver
uniprot_entry
7B2_HUMAN
resolver
uniprot_entry
C9J650_HUMAN
resolver
uniprot_entry
C9JNY7_HUMAN
resolver
uniprot_sec
P01164
resolver
uniprot_sec
Q6FHD0
resolver
uniprot_sec
Q9BS38
resolver
amino_acid_sequence
MVSRMVSTMLSGLLFWLASGWTPAFAYSPRTPDRVSEADIQRLLHGVMEQLGIARPRVEYPAHQAMNLVGPQSIEGGAHEGLQHLGPFGNIPNIVAELTGDNIPKDFSEDQGYPDPPNPCPVGKTADDGCLENTPDTAEFSREFQLHQHLFDPEHDYPGLGKWNKKLLYEKMKGGERRKRRSVNPYLQGQRLDNVVAKKSVPHFSDEDKDPE
uniprot
proteins
function
FUNCTION: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro (PubMed:7913882). Also capable of preventing aggregation of IAPP/islet amyloid polypeptide (PubMed:24042052). {ECO:0000269|PubMed:24042052, ECO:0000269|PubMed:7913882}.
uniprot
proteins
mass_dalton
23730
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved in the Golgi by a furin-like convertase to generate bioactive peptides. {ECO:0000250|UniProtKB:P12961}.; PTM: Sulfated on tyrosine residues. {ECO:0000250|UniProtKB:P12961}.
uniprot
proteins
protein_family
7B2 family
uniprot
proteins
pubmed
11439082
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1989596
uniprot
proteins
pubmed
24042052
uniprot
proteins
pubmed
3134253
uniprot
proteins
pubmed
6625600
uniprot
proteins
pubmed
7913882
uniprot
proteins
pubmed
8617287
uniprot
proteins
sequence_length
212
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01165}. Note=Neuroendocrine and endocrine secretory granules. {ECO:0000250|UniProtKB:P01165}.
uniprot
proteins