Kat7
entrez
303470
canonical
uniprot
Q810T5
canonical
ensembl
ENSRNOG00000022664
resolver
ensembl
ENSRNOG00055031901
resolver
ensembl
ENSRNOG00060024753
resolver
ensembl
ENSRNOG00065018143
resolver
ensp
ENSRNOP00000090504
resolver
ensp
ENSRNOP00000092089
resolver
ensp
ENSRNOP00000096120
resolver
enst
ENSRNOT00000116805
resolver
genesymbol
Kat7
resolver
genesymbol_syn
Hbo1
resolver
genesymbol_syn
Myst2
resolver
uniprot
A0A8I6GLG6
resolver
uniprot
Q80YN5
resolver
uniprot_entry
A0A8I6GLG6_RAT
resolver
uniprot_entry
KAT7_RAT
resolver
uniprot_sec
Q80YN5
resolver
activity_regulation
ACTIVITY REGULATION: Histone acetyltransferase activity is inhibited by GMNN in the context of a complex with CDT1, inhibiting histone H4 acetylation and DNA replication licensing. {ECO:0000250|UniProtKB:O95251}.
uniprot
proteins
amino_acid_sequence
MAIGVKRNAGSSSDGTEDSDFSTDLEHTDSSESDGTSRRSARVTRSSARLSQSSQDSSPVRNLPSFGTEEPAYSTRRVTRSQQQPTPVTPKKYPLRQTRSSGSETEQAVDFSDRETKNTADHDESPPRTPTGNAPSSESDIDISSPNVSHDESIAKDMSLKDSGSDLSHRPKRRRFHESYNFNMKCPTPGCNSLGHLTGKHERHFSISGCPLYHNLSADECKVRAQSRDKQIEERMLSHRQDDNNRHATRHQAPTERQLRYKEKVAELRKKRNSGLSKEQKEKYMEHRQTYGNTREPLLENLTSEYDLDLFRRAQARASEDLEKLRLQGQITEGSNMIKTIAFGRYELDTWYHSPYPEEYARLGRLYMCEFCLKYMKSQTILRRHMAKCVWKHPPGDEIYRKGSISVFEVDGKKNKIYCQNLCLLAKLFLDHKTLYYDVEPFLFYVMTEADNTGCHLIGYFSKEKNSFLNYNVSCILTMPQYMRQGYGKMLIDFSYLLSKVEEKVGSPERPLSDLGLISYRSYWKEVLLRYLHNFQGKEISIKEISQETAVNPVDIVSTLQALQMLKYWKGKHLVLKRQDLIDEWIAKEAKRSNSNKTMDPSCLKWTPPKGT
uniprot
proteins
ec_number
2.3.1.48
uniprot
proteins
function
FUNCTION: Catalytic subunit of histone acetyltransferase HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), thereby regulating various processes, such as gene transcription, protein ubiquitination, immune regulation, stem cell pluripotent and self-renewal maintenance and embryonic development. Some complexes also catalyze acetylation of histone H4 at 'Lys-5', 'Lys-8' and 'Lys-12' (H4K5ac, H4K8ac and H4K12ac, respectively), regulating DNA replication initiation, regulating DNA replication initiation. Specificity of the HBO1 complexes is determined by the scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE (JADE1, JADE2 and JADE3) scaffold direct KAT7/HBO1 specificity towards histone H4. H3K14ac promotes transcriptional elongation by facilitating the processivity of RNA polymerase II. Acts as a key regulator of hematopoiesis by forming a complex with BRD1/BRPF2, directing KAT7/HBO1 specificity towards H3K14ac and promoting erythroid differentiation (By similarity). H3K14ac is also required for T-cell development (By similarity). KAT7/HBO1-mediated acetylation facilitates two consecutive steps, licensing and activation, in DNA replication initiation: H3K14ac facilitates the activation of replication origins, and histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac) facilitates chromatin loading of MCM complexes, promoting DNA replication licensing. Acts as a positive regulator of centromeric CENPA assembly: recruited to centromeres and mediates histone acetylation, thereby preventing centromere inactivation mediated by SUV39H1, possibly by increasing histone turnover/exchange. Involved in nucleotide excision repair: phosphorylation by ATR in response to ultraviolet irradiation promotes its localization to DNA damage sites, where it mediates histone acetylation to facilitate recruitment of XPC at the damaged DNA sites. Acts as an inhibitor of NF-kappa-B independently of its histone acetyltransferase activity (By similarity). {ECO:0000250|UniProtKB:O95251, ECO:0000250|UniProtKB:Q5SVQ0}.
uniprot
proteins
mass_dalton
70514
uniprot
proteins
pathway_participation
PATHWAY: Protein degradation; proteasomal ubiquitin-dependent pathway. {ECO:0000250|UniProtKB:Q5SVQ0}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-51 and Ser-54 by ATR in response to DNA damage, promoting its ubiquitination by the CRL4(DDB2) complex and subsequent degradation. Phosphorylation at Ser-51 and Ser-54 by ATR in response to ultraviolet-induced DNA, promotes localization to DNA damage sites. Phosphorylation at Ser-58 by PLK1 during mitosis seems important for prereplicative complex formation and DNA replication licensing, and requires prior phosphorylation at Thr-86 and Thr-89 by CDK1 (By similarity). Phosphorylated by MAP2K1, which accelerates its degradation (By similarity). {ECO:0000250|UniProtKB:O95251, ECO:0000250|UniProtKB:Q5SVQ0}.; PTM: Ubiquitinated at Lys-339, leading to proteasomal degradation. Ubiquitinated by the CRL4(DDB2) complex following phosphorylation by ATR, leading to its subsequent degradation. {ECO:0000250|UniProtKB:O95251}.; PTM: Autoacetylation at Lys-433 is required for proper function. {ECO:0000250|UniProtKB:Q9H7Z6}.
uniprot
proteins
protein_family
MYST (SAS/MOZ) family
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
612
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O95251}. Chromosome {ECO:0000250|UniProtKB:O95251}. Chromosome, centromere {ECO:0000250|UniProtKB:O95251}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q5SVQ0}. Note=Associates with replication origins specifically during the G1 phase of the cell cycle. Localizes to transcription start sites. Localizes to ultraviolet-induced DNA damage sites following phosphorylation by ATR. Localizes to centromeres in G1 phase. {ECO:0000250|UniProtKB:O95251}.
uniprot
proteins