Kcnh3
entrez
27150
canonical
uniprot
O89047
canonical
ensembl
ENSRNOG00000057315
resolver
ensembl
ENSRNOG00055025277
resolver
ensembl
ENSRNOG00060009808
resolver
ensembl
ENSRNOG00065021380
resolver
ensp
ENSRNOP00000071001
resolver
ensp
ENSRNOP00055035577
resolver
ensp
ENSRNOP00060012941
resolver
ensp
ENSRNOP00065029291
resolver
enst
ENSRNOT00000086611
resolver
enst
ENSRNOT00055043586
resolver
enst
ENSRNOT00060016565
resolver
enst
ENSRNOT00065036345
resolver
genesymbol
Kcnh3
resolver
genesymbol_syn
Elk2
resolver
uniprot_entry
KCNH3_RAT
resolver
amino_acid_sequence
MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEVMQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEKGEVALFLVSHKDISETKNRGGPDNWKERGGGRRRYGRAGSKGFNANRRRSRAVLYHLSGHLQKQPKGKHKLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVTVPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYVTTWFLLDVIAALPFDLLHAFKVNVYVGAHLLKTVRLLRLLRLLPRLDRYSQYSAVVLTLLMAVFALLAHWVACVWFYIGQQEIENSESELPEIGWLQELARRLETPYYLVSRSPDGGNSSGQSENCSSSGGGSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTELLQSLPDELRADIAMHLHKEVLQLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPQREQVVKANADVKGLTYCVLQCLQLAGLHESLALYPEFAPRFSRGLRGELSYNLGAGGVSAEVDTSSLSGDNTLMSTLEEKETDGEQGHTISPAPADEPSSPLLSPGCTSSSSAAKLLSPRRTAPRPRLGGRGRPSRAGVLKPEAGPSAHPRTLDGLQLPPMPWNVPPDLSPRVVDGIEDGCGSDQHKFSFRVGQSGPECSSSPSPGTESGLLTVPLVPSEARNTDTLDKLRQAVTELSEQVLQMREGLQSLRQAVQLILVPQGEGQCPRVSGEGPCPATASGLLQPLRVDTGASSYCLQPPAGSVLSGTWPHPRPGHPPPLMAPWPWGPPASQSSPWPRATALWTSTSDSEPPGSGDLCSEPSTPASPPPPEEGARTGTPAPVSQAEATSTGEPPPGSGGRALPWDPHSLEMVLIGCHGPGSVQWTQEEGTGV
uniprot
proteins
function
FUNCTION: Pore-forming (alpha) subunit of a voltage-gated inwardly rectifying potassium channel (PubMed:9824707). Charactherized by a fast rate of activation during depolarization followed by a rapid inactivation at much more depolarized value causing inward rectification due to a C-type inactivation mechanism (PubMed:9824707). Exhibits a rapid recovery from inactivation (PubMed:9824707). {ECO:0000269|PubMed:9824707}.
uniprot
proteins
mass_dalton
117580
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. N-glycosylation mediates traffick to the cell membrane but is not necessary for voltage-gated potassium channel activity. {ECO:0000250|UniProtKB:Q9WVJ0}.
uniprot
proteins
protein_family
H (Eag) (TC 1.A.1.20) subfamily
uniprot
proteins
protein_family
Kv12.2/KCNH3 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
10455180
uniprot
proteins
pubmed
10718922
uniprot
proteins
pubmed
9714851
uniprot
proteins
pubmed
9824707
uniprot
proteins
sequence_length
1087
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9WVJ0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9WVJ0}. Note=Expression on the cell membrane requires at least one of the three glycosylation sites to carry a sugar chain irrespective of their positions. {ECO:0000250|UniProtKB:Q9WVJ0}.
uniprot
proteins
transmembrane_region
TRANSMEM 229..249; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 260..280; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 303..323; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 332..352; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 362..382; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 483..503; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins