CREBZF
entrez
58487
canonical
uniprot
Q9NS37
canonical
ensembl
ENSG00000137504
resolver
ensp
ENSP00000433459
resolver
ensp
ENSP00000434281
resolver
ensp
ENSP00000435762
resolver
ensp
ENSP00000507358
resolver
ensp
ENSP00000520895
resolver
enst
ENST00000490820
resolver
enst
ENST00000525639
resolver
enst
ENST00000527447
resolver
enst
ENST00000682836
resolver
enst
ENST00000850607
resolver
genesymbol
CREBZF
resolver
genesymbol_syn
ZF
resolver
hgnc
HGNC:24905
resolver
uniprot
B2R8Q9
resolver
uniprot
E9PIM0
resolver
uniprot
Q0P5U9
resolver
uniprot
Q52LT3
resolver
uniprot_entry
E9PIM0_HUMAN
resolver
uniprot_entry
ZHANG_HUMAN
resolver
uniprot_sec
B2R8Q9
resolver
uniprot_sec
Q0P5U9
resolver
uniprot_sec
Q52LT3
resolver
amino_acid_sequence
MRHSLTKLLAASGSNSPTRSESPEPAATCSLPSDLTRAAAGEEETAAAGSPGRKQQFGDEGELEAGRGSRGGVAVRAPSPEEMEEEAIASLPGEETEDMDFLSGLELADLLDPRQPDWHLDPGLSSPGPLSSSGGGSDSGGLWRGDDDDEAAAAEMQRFSDLLQRLLNGIGGCSSSSDSGSAEKRRRKSPGGGGGGGSGNDNNQAATKSPRKAAAAAARLNRLKKKEYVMGLESRVRGLAAENQELRAENRELGKRVQALQEESRYLRAVLANETGLARLLSRLSGVGLRLTTSLFRDSPAGDHDYALPVGKQKQDLLEEDDSAGGVCLHVDKDKVSVEFCSACARKASSSLKM
uniprot
proteins
function
FUNCTION: Strongly activates transcription when bound to HCFC1. Suppresses the expression of HSV proteins in cells infected with the virus in a HCFC1-dependent manner. Also suppresses the HCFC1-dependent transcriptional activation by CREB3 and reduces the amount of CREB3 in the cell. Able to down-regulate expression of some cellular genes in CREBZF-expressing cells. {ECO:0000269|PubMed:10871379, ECO:0000269|PubMed:15705566}.
uniprot
proteins
mass_dalton
37134
uniprot
proteins
mutagenesis
MUTAGEN 303; /note="D->A: Significantly reduced binding to HCFC1."; /evidence="ECO:0000269|PubMed:10871379"; MUTAGEN 304; /note="H->A: Significantly reduced binding to HCFC1."; /evidence="ECO:0000269|PubMed:10871379"; MUTAGEN 306; /note="Y->A: Does not interact with HCFC1 and is inefficient at inhibiting CREB3 transcriptional activity. Does not colocalize with CREB3 in promyelocytic leukemia protein nuclear bodies (PML-NB)."; /evidence="ECO:0000269|PubMed:10871379, ECO:0000269|PubMed:15705566
uniprot
proteins
protein_family
ATF subfamily
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
pubmed
10871379
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15705566
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
354
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15705566}. Note=Colocalizes in promyelocytic leukemia protein nuclear bodies (PML-NB) with CREB3 and HCFC1.
uniprot
proteins