ADI1
entrez
55256
canonical
uniprot
Q9BV57
canonical
ensembl
ENSG00000182551
resolver
ensp
ENSP00000333666
resolver
ensp
ENSP00000371525
resolver
genesymbol
ADI1
resolver
genesymbol_syn
MTCBP1
resolver
hgnc
HGNC:30576
resolver
uniprot
D6W4Y3
resolver
uniprot
Q53HW3
resolver
uniprot
Q53QD3
resolver
uniprot
Q57YV7
resolver
uniprot
Q68CK2
resolver
uniprot
Q6ZSF7
resolver
uniprot
Q7Z512
resolver
uniprot
Q96P85
resolver
uniprot
Q9NV57
resolver
uniprot_entry
MTND_HUMAN
resolver
uniprot_sec
D6W4Y3
resolver
uniprot_sec
Q53HW3
resolver
uniprot_sec
Q53QD3
resolver
uniprot_sec
Q57YV7
resolver
uniprot_sec
Q68CK2
resolver
uniprot_sec
Q6ZSF7
resolver
uniprot_sec
Q7Z512
resolver
uniprot_sec
Q96P85
resolver
uniprot_sec
Q9NV57
resolver
amino_acid_sequence
MVQAWYMDDAPGDPRQPHRPDPGRPVGLEQLRRLGVLYWKLDADKYENDPELEKIRRERNYSWMDIITICKDKLPNYEEKIKMFYEEHLHLDDEIRYILDGSGYFDVRDKEDQWIRIFMEKGDMVTLPAGIYHRFTVDEKNYTKAMRLFVGEPVWTAYNRPADHFEARGQYVKFLAQTA
uniprot
proteins
ec_number
1.13.11.53
uniprot
proteins
ec_number
1.13.11.54
uniprot
proteins
function
FUNCTION: Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site (By similarity). Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway (PubMed:15938715). Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity). Also down-regulates cell migration mediated by MMP14 (PubMed:14718544). Necessary for hepatitis C virus replication in an otherwise non-permissive cell line (PubMed:11602742). {ECO:0000255|HAMAP-Rule:MF_03154, ECO:0000269|PubMed:11602742, ECO:0000269|PubMed:14718544, ECO:0000269|PubMed:15938715}.
uniprot
proteins
mass_dalton
21498
uniprot
proteins
mutagenesis
MUTAGEN 94; /note="E->A: Loss of aci-reductone dioxygenase activity."; /evidence="ECO:0000269|PubMed:15938715
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6. {ECO:0000255|HAMAP-Rule:MF_03154}.
uniprot
proteins
protein_family
Acireductone dioxygenase (ARD) family
uniprot
proteins
pubmed
11602742
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14718544
uniprot
proteins
pubmed
15221005
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
15938715
uniprot
proteins
pubmed
19892738
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
179
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000303|PubMed:14718544}. Nucleus {ECO:0000303|PubMed:14718544}. Cell membrane {ECO:0000303|PubMed:14718544}; Peripheral membrane protein {ECO:0000303|PubMed:14718544}; Cytoplasmic side {ECO:0000303|PubMed:14718544}. Note=Localizes to the plasma membrane when complexed to MMP14. {ECO:0000303|PubMed:14718544}.
uniprot
proteins