Sh2d1b2
entrez
545378
canonical
uniprot
Q45HK4
canonical
ensembl
ENSMUSG00000073494
resolver
ensp
ENSMUSP00000125121
resolver
enst
ENSMUST00000162752
resolver
genesymbol
Sh2d1b2
resolver
genesymbol_syn
Eat2b
resolver
genesymbol_syn
Sh2d1c
resolver
uniprot
Q45GR3
resolver
uniprot_entry
SH21C_MOUSE
resolver
uniprot_sec
Q45GR3
resolver
amino_acid_sequence
MDLPYYHGCLTKRECEALLLKGGVDGNFLIRDSESVPGALCLCVSFKKLVYNYRIFREKNGYYRIETEPSTPKTIFPNLEELISKFKTPGQGMVVHLSNPIMRSGFCPGARRLNLEANVYENTDEEYVDVLP
uniprot
proteins
function
FUNCTION: Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family. In SLAM signaling may cooperate with Sh2d1a/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through Cd244/2b4. However, conflicting results are reported which may reflect the use of different strain backgrounds. Proposed to act as an inhibitor of Cd244-mediated NK cell function including cytotoxicity and IFN-gamma production, the latter found also by triggering Klra4 and Klrk1 next to Cd244 (PubMed:16127454). Seems to positively regulate Cd244- and Cd84-dependent NK cell functions implicating Cd244-mediated phosphorylation of Vav1 (PubMed:20962259). {ECO:0000269|PubMed:16127454, ECO:0000269|PubMed:20962259}.
uniprot
proteins
mass_dalton
15044
uniprot
proteins
pubmed
16127454
uniprot
proteins
pubmed
16425036
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20962259
uniprot
proteins
sequence_length
132
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
uniprot
proteins