Trnt1
entrez
70047
canonical
uniprot
Q8K1J6
canonical
ensembl
ENSMUSG00000013736
resolver
ensp
ENSMUSP00000060900
resolver
ensp
ENSMUSP00000108873
resolver
ensp
ENSMUSP00000108874
resolver
ensp
ENSMUSP00000292182
resolver
ensp
ENSMUSP00000292189
resolver
genesymbol
Trnt1
resolver
uniprot
Q3TKW1
resolver
uniprot
Q3UX99
resolver
uniprot
Q920N6
resolver
uniprot
Q9CSX0
resolver
uniprot_entry
TRNT1_MOUSE
resolver
uniprot_sec
Q3TKW1
resolver
uniprot_sec
Q3UX99
resolver
uniprot_sec
Q920N6
resolver
uniprot_sec
Q9CSX0
resolver
amino_acid_sequence
MQSVLYPWHRQVLRCSWSRLCLLKRYLFTMKLQSPEFQSLFTEGLKSLTELFAKENHELRIAGGAVRDLLNGVKPQDVDFATTATPTQMKEMFQSAGIRMINNKGEKHGTITARLHEENFEVTTLRIDVTTDGRHAEVEFTTDWQKDAERRDLTINSMFLGFDGTLFDYFNGYADLKNKKVRFVGHAKQRIQEDYLRILRYFRFYGRIVDRPGDHDHETLEAIAENAKGLAGISGERIWVELKKILTGDHVNHLIHLIYDLGVAPHIGLPANANLEEFNKVSKNVEGFSPKPMTLLASLFKVQDDVTKLDLRLKISKEEKNLGLFIVKNRKDLIKATDSSEPLKPYQDFVIDSREPDATARVCELLKYQGEHGLLKEMQQWSVPPFPVSGHDIRKVGISSGKEIGALLQQLREQWKKSGYRMEKDELLSYIKKT
uniprot
proteins
ec_number
2.7.7.72
uniprot
proteins
function
FUNCTION: Nucleotidyltransferase that catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs, which is necessary for the attachment of amino acids to the 3' terminus of tRNA molecules, using CTP and ATP as substrates. tRNA 3'-terminal CCA addition is required both for tRNA processing and repair. Promotes tRNA repair and recycling downstream of the ribosome-associated quality control (RQC) pathway by mediating addition of the tRNA 3'-terminal CCA following cleavage by ANKZF1 and repair by ELAC1. Also involved in tRNA surveillance by mediating tandem CCA addition to generate a CCACCA at the 3' terminus of unstable tRNAs and tRNA-like transcripts. While stable tRNAs receive only 3'-terminal CCA, unstable tRNAs beginning with GG are marked with CCACCA and rapidly degraded. The structural flexibility of RNA controls the choice between CCA versus CCACCA addition: following the first CCA addition cycle, nucleotide-binding to the active site triggers a clockwise screw motion, producing torque on the RNA. This ejects stable RNAs, whereas unstable RNAs are refolded while bound to the enzyme and subjected to a second CCA catalytic cycle. {ECO:0000250|UniProtKB:Q96Q11}.
uniprot
proteins
mass_dalton
49895
uniprot
proteins
protein_family
TRNA nucleotidyltransferase/poly(A) polymerase family
uniprot
proteins
pubmed
11504732
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
434
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q96Q11}. Cytoplasm {ECO:0000250|UniProtKB:Q96Q11}. Nucleus {ECO:0000250|UniProtKB:Q96Q11}.
uniprot
proteins