Gramd1a
entrez
361550
canonical
uniprot
Q3KR56
canonical
ensembl
ENSRNOG00000021106
resolver
ensp
ENSRNOP00000028660
resolver
ensp
ENSRNOP00000082331
resolver
enst
ENSRNOT00000028660
resolver
genesymbol
Gramd1a
resolver
uniprot
A0A0H2UHS9
resolver
uniprot
Q6Y8E7
resolver
uniprot_entry
A0A0H2UHS9_RAT
resolver
uniprot_entry
ASTRA_RAT
resolver
uniprot_sec
Q6Y8E7
resolver
amino_acid_sequence
MFDTTPHSGRSSPSSSPSLRKRLQLLPPSRPPSAPEPEPGTMVEKGSDSSSEKSGVSGTLSTQSLGSRNFIRNSKKMQSWYSMLCPTYKQRNEDFRKLFSKLPEAERLIVDYSCALQREILLQGRLYLSENWICFYSNIFRWETTISIQLKEVTCLKKEKTAKLIPNAIQICTESEKHFFTSFGARDRCFLLIFRLWQNALLEKTLSPRELWHLVHQCYGSELGLTSEDEDYVCPLQLNGLGSPKEVGDVIALSDISPSGAADRSQEPSPVGSRCGRVTPNLSRASSDADHGAEEDKEDQTDSQLDASSSQTVTPVAEPLSAEPAPPDGPTSNLGPLDLLSREELLTDTSNSSSSTGEEGDLAALLPDLSGRLLINSVFHVGAERLQQMLFSDSPFLQGFLQQRKFTDVTLSPWSSDSKCHQRRVLTYTIPISNQLGPKSASVVETQTLFRRGPQAGGCVVDSEVLTQGIPYQDYFYTAHRYCILGLARNKARLRVSSEIRYRKQPWSLVKSLIEKSSWTGIEDYFHHLDRELAKAEKVSLEEGGKDARGLLSGLRRRKRPLSWRGHRDGPQHPDPDPCTQTSMHTSGSLSSRFSEPSVDQGPGAGIPSALVLISIVLIVLIALNALLFYRLWSLERTAHTFESWHSLALAKGKFPQTATEWAEILALQKHFHSVEVHKWRQILRASVELLDEMKFSLEKLHQGITVPDPPLDTQPHPDDSFP
uniprot
proteins
function
FUNCTION: Cholesterol transporter that mediates non-vesicular transport of cholesterol from the plasma membrane (PM) to the endoplasmic reticulum (ER) (By similarity). Contains unique domains for binding cholesterol and the PM, thereby serving as a molecular bridge for the transfer of cholesterol from the PM to the ER (By similarity). Plays a crucial role in cholesterol homeostasis and has the unique ability to localize to the PM based on the level of membrane cholesterol (By similarity). In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) which is mediated by the GRAM domain (By similarity). At the EPCS, the sterol-binding VASt/ASTER domain binds to the cholesterol in the PM and facilitates its transfer from the PM to ER (By similarity). May play a role in tumor progression (By similarity). Plays a role in autophagy regulation and is required for biogenesis of the autophagosome. This function in autophagy requires its cholesterol-transfer activity (By similarity). {ECO:0000250|UniProtKB:Q8VEF1, ECO:0000250|UniProtKB:Q96CP6}.
uniprot
proteins
mass_dalton
80684
uniprot
proteins
pubmed
15033532
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
723
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q96CP6}; Single-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q96CP6}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:Q96CP6}. Note=In lipid-poor conditions localizes to the ER membrane and in response to excess cholesterol in the PM is recruited to the endoplasmic reticulum-plasma membrane contact sites (EPCS) (By similarity). Localizes to distinct EPCS than GRAMD2A and ESYT2/3 (By similarity). {ECO:0000250|UniProtKB:Q8VEF1, ECO:0000250|UniProtKB:Q96CP6}.
uniprot
proteins
transmembrane_region
TRANSMEM 610..630; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins