Ajuba
entrez
85265
canonical
uniprot
Q5U2Z2
canonical
ensembl
ENSRNOG00000012791
resolver
ensembl
ENSRNOG00055012018
resolver
ensembl
ENSRNOG00060023233
resolver
ensembl
ENSRNOG00065031012
resolver
ensp
ENSRNOP00000017753
resolver
ensp
ENSRNOP00055016439
resolver
ensp
ENSRNOP00060033153
resolver
ensp
ENSRNOP00065043950
resolver
enst
ENSRNOT00000017753
resolver
enst
ENSRNOT00055020424
resolver
enst
ENSRNOT00060040174
resolver
enst
ENSRNOT00065053463
resolver
genesymbol
Ajuba
resolver
genesymbol_syn
Jub
resolver
uniprot
Q99ND4
resolver
uniprot_entry
AJUBA_RAT
resolver
uniprot_sec
Q99ND4
resolver
amino_acid_sequence
MERLGEKASRLLEKLRLSDSGSAKFGRRKGEASRSGSDGTPGAGKGRLSGLGGPRKSGHRGANGGPGDEALEPAREQGPLDAERNARGSFEAQRFEGSFPGGPPPTRALPLPLSSPPDFRLETTAPALSPRSSFASSSASDASKPSSPRGSLLLDGAGASGAGGSRPCSNRTSGISMGYDQRHGSPLPAGPCLFGLPLTTAPSGYSSGGVPSAYPELHAALDRLCAHRPVGFGCQESRHSYPPALGSPGALTGAVVGTAGPLERRGTQPGRHSVTGYGDCAAGARYQDELTALLRLTVATGGREAGARGEPLGIEPSGLEESPGSFVPEASRSRIREPEAREDYFGTCIKCNKGIYGQSNACQALDSLYHTQCFVCCSCGRTLRCKAFYSVNGSVYCEEDYLFSGFQEAAEKCCVCGHLILEKILQAMGKSYHPGCFRCIVCNKCLDGVPFTVDFSNQVYCVTDYHKNYAPKCAACGQPILPSEGCEDIVRVISMDRDYHFECYHCEDCRMQLSDEEGCCCFPLDGHLLCHGCHMQRLSARQPPTNYI
uniprot
proteins
function
FUNCTION: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, mitosis, cell-cell adhesion, cell differentiation, proliferation and migration. Contributes to the linking and/or strengthening of epithelia cell-cell junctions in part by linking adhesive receptors to the actin cytoskeleton. May be involved in signal transduction from cell adhesion sites to the nucleus. Plays an important role in regulation of the kinase activity of AURKA for mitotic commitment. Also a component of the IL-1 signaling pathway modulating IL-1-induced NFKB1 activation by influencing the assembly and activity of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex. Functions as an HDAC-dependent corepressor for a subset of GFI1 target genes. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1 (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
58081
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by LATS2 during mitosis. Phosphorylated by AURKA (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Zyxin/ajuba family
uniprot
proteins
pubmed
11860269
uniprot
proteins
sequence_length
548
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11860269}. Cell membrane {ECO:0000269|PubMed:11860269}. Cell junction {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, P-body {ECO:0000250}. Note=Shuttles between the cytoplasm and the nucleus (By similarity). Localizes on centrosomes during G2-M phase (By similarity). Colocalizes with GFI1 in the nucleus (By similarity). Preferentially colocalizes with cadherin-adhesive complexes at sites of cell-cell contacts. {ECO:0000250}.
uniprot
proteins