ADCYAP1
entrez
116
canonical
uniprot
P18509
canonical
ensembl
ENSG00000141433
resolver
ensp
ENSP00000411658
resolver
ensp
ENSP00000462647
resolver
ensp
ENSP00000794066
resolver
enst
ENST00000450565
resolver
enst
ENST00000579794
resolver
genesymbol
ADCYAP1
resolver
hgnc
HGNC:241
resolver
uniprot
B2R7N4
resolver
uniprot
B7Z222
resolver
uniprot
Q52LQ0
resolver
uniprot_entry
B7Z222_HUMAN
resolver
uniprot_entry
PACA_HUMAN
resolver
uniprot_sec
B2R7N4
resolver
uniprot_sec
Q52LQ0
resolver
amino_acid_sequence
MTMCSGARLALLVYGIIMHSSVYSSPAAAGLRFPGIRPEEEAYGEDGNPLPDFDGSEPPGAGSPASAPRAAAAWYRPAGRRDVAHGILNEAYRKVLDQLSAGKHLQSLVARGVGGSLGGGAGDDAEPLSKRHSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNKGRRIAYL
uniprot
proteins
function
FUNCTION: PACAP is a neuropeptide involved in diverse array of physiological processes through activating the PACAP subfamily of class B1 G protein-coupled receptors: VIP receptor 1 (VIPR1), VIP receptor 2 (VIPR2), and PACAP type I receptor (ADCYAP1R1) (PubMed:11175907, PubMed:23800469, PubMed:32047270, PubMed:32004469, PubMed:36385145). Exerts neuroprotective and general cytoprotective effects due to anti-apoptotic, anti-inflammatory, and antioxidant actions (PubMed:23800469). Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway (PubMed:23800469). In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity). PACAP exists in two bioactive forms from proteolysis of the same precursor protein, PACAP27 and PACAP38, which differ by eleven amino acid residues in the C-terminus (PubMed:32047270, PubMed:32004469). {ECO:0000250|UniProtKB:O70176, ECO:0000250|UniProtKB:P13589, ECO:0000269|PubMed:11175907, ECO:0000269|PubMed:23800469, ECO:0000269|PubMed:32004469, ECO:0000269|PubMed:32047270, ECO:0000269|PubMed:36385145}.
uniprot
proteins
mass_dalton
18835
uniprot
proteins
mutagenesis
MUTAGEN 150; /note="V->G: Strongly reduced affinity for ADCYAP1R1."; /evidence="ECO:0000269|PubMed:17470806"; MUTAGEN 151; /note="K->E: Strongly reduced affinity for ADCYAP1R1."; /evidence="ECO:0000269|PubMed:17470806"; MUTAGEN 152; /note="K->E: Strongly reduced affinity for ADCYAP1R1."; /evidence="ECO:0000269|PubMed:17470806"; MUTAGEN 153; /note="Y->A: Strongly reduced affinity for ADCYAP1R1."; /evidence="ECO:0000269|PubMed:17470806"; MUTAGEN 157; /note="V->A: Strongly reduced affinity for ADCYAP1R1."; /evidence="ECO:0000269|PubMed:17470806"; MUTAGEN 158; /note="L->A: Strongly reduced affinity for ADCYAP1R1."; /evidence="ECO:0000269|PubMed:17470806
uniprot
proteins
protein_family
Glucagon family
uniprot
proteins
pubmed
11175907
uniprot
proteins
pubmed
11968092
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
1483839
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1730060
uniprot
proteins
pubmed
1739432
uniprot
proteins
pubmed
17470806
uniprot
proteins
pubmed
2302217
uniprot
proteins
pubmed
23800469
uniprot
proteins
pubmed
32004469
uniprot
proteins
pubmed
32047270
uniprot
proteins
pubmed
35477937
uniprot
proteins
pubmed
36385145
uniprot
proteins
pubmed
8504103
uniprot
proteins
sequence_length
176
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins