Pacsin1
entrez
23969
canonical
uniprot
Q61644
canonical
ensembl
ENSMUSG00000040276
resolver
ensp
ENSMUSP00000044168
resolver
ensp
ENSMUSP00000094973
resolver
ensp
ENSMUSP00000110523
resolver
ensp
ENSMUSP00000155999
resolver
ensp
ENSMUSP00000156003
resolver
ensp
ENSMUSP00000181471
resolver
enst
ENSMUST00000045896
resolver
enst
ENSMUST00000097360
resolver
enst
ENSMUST00000114873
resolver
enst
ENSMUST00000231669
resolver
enst
ENSMUST00000232437
resolver
genesymbol
Pacsin1
resolver
genesymbol_syn
Pacsin
resolver
uniprot
Q3TYF2
resolver
uniprot
Q543Y7
resolver
uniprot_entry
PACN1_MOUSE
resolver
uniprot_entry
Q3TYF2_MOUSE
resolver
uniprot_entry
Q543Y7_MOUSE
resolver
amino_acid_sequence
MSGSYDEASEEITDSFWEVGNYKRTVKRIDDGHRLCNDLMSCVQERAKIEKAYAQQLTDWAKRWRQLIEKGPQYGSLERAWGAMMTEADKVSELHQEVKNSLLNEDLEKVKNWQKDAYHKQIMGGFKETKEAEDGFRKAQKPWAKKMKELEAAKKAYHLACKEERLAMTREMNSKTEQSVTPEQQKKLVDKVDKCRQDVQKTQEKYEKVLEDVGKTTPQYMEGMEQVFEQCQQFEEKRLVFLKEVLLDIKRHLNLAENSSYMHVYRELEQAIRGADAQEDLRWFRSTSGPGMPMNWPQFEEWNPDLPHTTAKKEKQPKKAEGATLSNATGAVESTSQAGDRGSVSSYDRGQTYATEWSDDESGNPFGGNEANGGANPFEDDAKGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVEAI
uniprot
proteins
function
FUNCTION: Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission. {ECO:0000269|PubMed:11082044, ECO:0000269|PubMed:20404169, ECO:0000269|PubMed:21926968, ECO:0000269|PubMed:23035120}.
uniprot
proteins
mass_dalton
50575
uniprot
proteins
mutagenesis
MUTAGEN 122..123; /note="IM->FF: Increases membrane tubulation."; /evidence="ECO:0000269|PubMed:20404169"; MUTAGEN 122..123; /note="IM->QQ: Abolishes membrane tubulation. No effect on phospholipid binding."; /evidence="ECO:0000269|PubMed:20404169"; MUTAGEN 127; /note="K->E: Abolishes membrane tubulation; when associated with E-130."; /evidence="ECO:0000269|PubMed:20404169"; MUTAGEN 130; /note="K->E: Abolishes membrane tubulation; when associated with E-127."; /evidence="ECO:0000269|PubMed:20404169"; MUTAGEN 145..148; /note="KKMK->EEME: Abolishes membrane tubulation."; /evidence="ECO:0000269|PubMed:20404169"; MUTAGEN 400; /note="E->R: Impairs interaction with DNM1."; MUTAGEN 434; /note="P->L: Abolishes interaction with DNM1, MAPT, SYNJ1 and WASL."; /evidence="ECO:0000269|PubMed:11082044, ECO:0000269|PubMed:20404169, ECO:0000269|PubMed:23035120
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC).
uniprot
proteins
protein_family
PACSIN family
uniprot
proteins
pubmed
11082044
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15930129
uniprot
proteins
pubmed
16627472
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
20404169
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21926968
uniprot
proteins
pubmed
23035120
uniprot
proteins
pubmed
9746365
uniprot
proteins
sequence_length
441
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cell projection {ECO:0000250}. Synapse, synaptosome {ECO:0000250}. Cell projection, ruffle membrane. Membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane; Peripheral membrane protein. Synapse. Cytoplasm, cytosol. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=In primary neuronal cultures, present at a high level in presynaptic nerve terminals and in the cell body. Colocalizes with DNM1 at vesicular structures in the cell body and neurites (By similarity). Colocalizes with MAPT in axons. {ECO:0000250}.
uniprot
proteins