Polr3h
entrez
78929
canonical
uniprot
Q9D2C6
canonical
ensembl
ENSMUSG00000022476
resolver
ensp
ENSMUSP00000023113
resolver
enst
ENSMUST00000023113
resolver
genesymbol
Polr3h
resolver
uniprot
Q91XE5
resolver
uniprot_entry
RPC8_MOUSE
resolver
uniprot_sec
Q91XE5
resolver
amino_acid_sequence
MFVLVEMVDTVRIPPWQFERKLNDSIAEELNKKLANKVVYNVGLCICLFDITKLEDAYVFPGDGASHTKVHFRYVVFHPFLDEILIGKIKGCSPEGVHVSLGFFDDILIPPESLQQPAKFDEAEQVWVWEYETEEGAHDLYMDTGEEIRFRVVDESFVDTSPTGPSSAEAASSSEELPKKEAPYTLVGSISEPGLGLLSWWTSN
uniprot
proteins
function
FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With CRCP/RPC9 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation (By similarity). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:O94285, ECO:0000250|UniProtKB:Q9Y535}.
uniprot
proteins
mass_dalton
22948
uniprot
proteins
protein_family
Eukaryotic RPB7/RPC8 RNA polymerase subunit family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
204
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y535}.
uniprot
proteins