EPC1
entrez
80314
canonical
uniprot
Q9H2F5
canonical
ensembl
ENSG00000120616
resolver
ensp
ENSP00000263062
resolver
ensp
ENSP00000318559
resolver
ensp
ENSP00000364251
resolver
ensp
ENSP00000775690
resolver
genesymbol
EPC1
resolver
hgnc
HGNC:19876
resolver
uniprot
B4DSC3
resolver
uniprot
D3DRX7
resolver
uniprot
Q5VW54
resolver
uniprot
Q5VW56
resolver
uniprot
Q5VW58
resolver
uniprot
Q8NAQ4
resolver
uniprot
Q8NE21
resolver
uniprot
Q96LF4
resolver
uniprot
Q96RR6
resolver
uniprot
Q9H7T7
resolver
uniprot_entry
EPC1_HUMAN
resolver
uniprot_sec
B4DSC3
resolver
uniprot_sec
D3DRX7
resolver
uniprot_sec
Q5VW54
resolver
uniprot_sec
Q5VW56
resolver
uniprot_sec
Q5VW58
resolver
uniprot_sec
Q8NAQ4
resolver
uniprot_sec
Q8NE21
resolver
uniprot_sec
Q96LF4
resolver
uniprot_sec
Q96RR6
resolver
uniprot_sec
Q9H7T7
resolver
amino_acid_sequence
MSKLSFRARALDASKPLPVFRCEDLPDLHEYASINRAVPQMPTGMEKEEESEHHLQRAISAQQVYGEKRDNMVIPVPEAESNIAYYESIYPGEFKMPKQLIHIQPFSLDAEQPDYDLDSEDEVFVNKLKKKMDICPLQFEEMIDRLEKGSGQQPVSLQEAKLLLKEDDELIREVYEYWIKKRKNCRGPSLIPSVKQEKRDGSSTNDPYVAFRRRTEKMQTRKNRKNDEASYEKMLKLRRDLSRAVTILEMIKRREKSKRELLHLTLEIMEKRYNLGDYNGEIMSEVMAQRQPMKPTYAIPIIPITNSSQFKHQEAMDVKEFKVNKQDKADLIRPKRKYEKKPKVLPSSAAATPQQTSPAALPVFNAKDLNQYDFPSSDEEPLSQVLSGSSEAEEDNDPDGPFAFRRKAGCQYYAPHLDQTGNWPWTSPKDGGLGDVRYRYCLTTLTVPQRCIGFARRRVGRGGRVLLDRAHSDYDSVFHHLDLEMLSSPQHSPVNQFANTSETNTSDKSFSKDLSQILVNIKSCRWRHFRPRTPSLHDSDNDELSCRKLYRSINRTGTAQPGTQTCSTSTQSKSSSGSAHFAFTAEQYQQHQQQLALMQKQQLAQIQQQQANSNSSTNTSQNLASNQQKSGFRLNIQGLERTLQGFVSKTLDSASAQFAASALVTSEQLMGFKMKDDVVLGIGVNGVLPASGVYKGLHLSSTTPTALVHTSPSTAGSALLQPSNITQTSSSHSALSHQVTAANSATTQVLIGNNIRLTVPSSVATVNSIAPINARHIPRTLSAVPSSALKLAAAANCQVSKVPSSSSVDSVPRENHESEKPALNNIADNTVAMEVT
uniprot
proteins
function
FUNCTION: Component of the NuA4 histone acetyltransferase (HAT) complex, a multiprotein complex involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A (PubMed:14966270). The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) by promoting homologous recombination (HR) (PubMed:27153538). The NuA4 complex is also required for spermatid development by promoting acetylation of histones: histone acetylation is required for histone replacement during the transition from round to elongating spermatids (By similarity). In the NuA4 complex, EPC1 is required to recruit MBTD1 into the complex (PubMed:32209463). {ECO:0000250|UniProtKB:Q8C9X6, ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:27153538, ECO:0000269|PubMed:32209463}.
uniprot
proteins
mass_dalton
93463
uniprot
proteins
mutagenesis
MUTAGEN 651; /note="L->D: Abolished interaction with MBTD1; when associated with D-660--663-D."; /evidence="ECO:0000269|PubMed:32209463"; MUTAGEN 659..663; /note="AASAL->DASAD: Abolished interaction with MBTD1; when associated with D-651."; /evidence="ECO:0000269|PubMed:32209463
uniprot
proteins
protein_family
Enhancer of polycomb family
uniprot
proteins
pubmed
10976108
uniprot
proteins
pubmed
12963728
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14966270
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15196461
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25787250
uniprot
proteins
pubmed
27153538
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
32209463
uniprot
proteins
sequence_length
836
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10976108}. Cytoplasm {ECO:0000250|UniProtKB:Q8C9X6}.
uniprot
proteins