Naip5
entrez
17951
canonical
uniprot
Q9R016
canonical
ensembl
ENSMUSG00000071203
resolver
ensp
ENSMUSP00000058611
resolver
enst
ENSMUST00000049789
resolver
genesymbol
Naip5
resolver
genesymbol_syn
Birc1e
resolver
genesymbol_syn
Naip-rs3
resolver
uniprot
O09121
resolver
uniprot
O09122
resolver
uniprot
P81703
resolver
uniprot
Q8CGT2
resolver
uniprot
Q9R029
resolver
uniprot_entry
BIR1E_MOUSE
resolver
uniprot_sec
O09121
resolver
uniprot_sec
O09122
resolver
uniprot_sec
P81703
resolver
uniprot_sec
Q8CGT2
resolver
uniprot_sec
Q9R029
resolver
amino_acid_sequence
MAEHGESSEDRISEIDYEFLPELSALLGVDAFQVAKSQEEEEHKERMKMKKGFNSQMRSEAKRLKTFETYDTFRSWTPQEMAAAGFYHTGVRLGVQCFCCSLILFGNSLRKLPIERHKKLRPECEFLQGKDVGNIGKYDIRVKRPEKMLRGGKARYHEEEARLESFEDWPFYAHGTSPRVLSAAGFVFTGKRDTVQCFSCGGSLGNWEEGDDPWKEHAKWFPKCEFLQSKKSSEEIAQYIQSYEGFVHVTGEHFVKSWVRRELPMVSAYCNDSVFANEELRMDMFKDWPQESPVGVEALVRAGFFYTGKKDIVRCFSCGGCLEKWAEGDDPMEDHIKFFPECVFLQTLKSSAEVIPTLQSQYALPEATETTRESNHGDAAAVHSTVVDLGRSEAQWFQEARSLSEQLRDNYTKATFRHMNLPEVCSSLGTDHLLSCDVSIISKHISQPVQEALTIPEVFSNLNSVMCVEGETGSGKTTFLKRIAFLWASGCCPLLYRFQLVFYLSLSSITPDQGLANIICAQLLGAGGCISEVCLSSSIQQLQHQVLFLLDDYSGLASLPQALHTLITKNYLSRTCLLIAVHTNRVRDIRLYLGTSLEIQEFPFYNTVSVLRKFFSHDIICVEKLIIYFIDNKDLQGVYKTPLFVAAVCTDWIQNASAQDKFQDVTLFQSYMQYLSLKYKATAEPLQATVSSCGQLALTGLFSSCFEFNSDDLAEAGVDEDEKLTTLLMSKFTAQRLRPVYRFLGPLFQEFLAAVRLTELLSSDRQEDQDLGLYYLRQIDSPLKAINSFNIFLYYVSSHSSSKAAPTVVSHLLQLVDEKESLENMSENEDYMKLHPQTFLWFQFVRGLWLVSPESSSSFVSEHLLRLALIFAYESNTVAECSPFILQFLRGKTLALRVLNLQYFRDHPESLLLLRSLKVSINGNKMSSYVDYSFKTYFENLQPPAIDEEYTSAFEHISEWRRNFAQDEEIIKNYENIRPRALPDISEGYWKLSPKPCKIPKLEVQVNNTDAADQALLQVLMEVFSASQSIEFRLFNSSGFLESICPALELSKASVTKCSMSRLELSRAEQELLLTLPALQSLEVSETNQLPEQLFHNLHKFLGLKELCVRLDGKPNVLSVLPREFPNLLHMEKLSIQTSTESDLSKLVKFIQNFPNLHVFHLKCDFLSNCESLMAVLASCKKLREIEFSGRCFEAMTFVNILPNFVSLKILNLKDQQFPDKETSEKFAQALGSLRNLEELLVPTGDGIHQVAKLIVRQCLQLPCLRVLTFHDILDDDSVIEIARAATSGGFQKLENLDISMNHKITEEGYRNFFQALDNLPNLQELNICRNIPGRIQVQATTVKALGQCVSRLPSLIRLHMLSWLLDEEDMKVINDVKERHPQSKRLIIFWKLIVPFSPVILE
uniprot
proteins
function
FUNCTION: Sensor component of the NLRC4 inflammasome that specifically recognizes and binds flagellin from pathogenic bacteria such as Legionella or Salmonella (PubMed:12526741, PubMed:21874021, PubMed:21918512, PubMed:29146805, PubMed:29182158). Association of pathogenic bacteria proteins drives in turn drive assembly and activation of the NLRC4 inflammasome, promoting caspase-1 activation, cytokine production and macrophage pyroptosis (PubMed:21874021, PubMed:21918512, PubMed:29146805, PubMed:29182158). The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria. The NLRC4 inflammasome senses Gram-negative bacteria such as L.pneumophila and P.aeruginosa, enteric pathogens S.typhimurium (Salmonella) and S.flexneri (PubMed:21874021, PubMed:21918512, PubMed:29146805, PubMed:29182158). May contribute to prevent motor-neuron apoptosis induced by a variety of signals (By similarity). {ECO:0000250|UniProtKB:Q13075, ECO:0000269|PubMed:12526741, ECO:0000269|PubMed:21874021, ECO:0000269|PubMed:21918512, ECO:0000269|PubMed:29146805, ECO:0000269|PubMed:29182158}.
uniprot
proteins
mass_dalton
159839
uniprot
proteins
mutagenesis
MUTAGEN 1..40; /note="Missing: Abolishes production of IL1B in response to bacterial flagellin."; /evidence="ECO:0000269|PubMed:29182158"; MUTAGEN 11; /note="R->I: Strongly reduces production of IL1B in response to bacterial flagellin; then associated with F-15."; /evidence="ECO:0000269|PubMed:29182158"; MUTAGEN 15; /note="I->F: Strongly reduces production of IL1B in response to bacterial flagellin; then associated with I-11."; /evidence="ECO:0000269|PubMed:29182158"; MUTAGEN 106..108; /note="GNS->STR: Strongly reduces production of IL1B in response to bacterial flagellin."; /evidence="ECO:0000269|PubMed:29182158"; MUTAGEN 626..627; /note="II->AA: Strongly reduced interaction with flagellin."; /evidence="ECO:0000269|PubMed:29146805"; MUTAGEN 837..838; /note="QT->AA: Mildly reduced interaction with flagellin."; /evidence="ECO:0000269|PubMed:29146805"; MUTAGEN 839..840; /note="FL->AA: Mildly reduced interaction with flagellin."; /evidence="ECO:0000269|PubMed:29146805"; MUTAGEN 840; /note="L->R: Strongly reduces production of IL1B in response to bacterial flagellin."; /evidence="ECO:0000269|PubMed:29182158"; MUTAGEN 841..842; /note="WF->AA: Mildly reduced interaction with flagellin."; /evidence="ECO:0000269|PubMed:29146805"; MUTAGEN 843..844; /note="QF->AA: Strongly reduced interaction with flagellin."; /evidence="ECO:0000269|PubMed:29146805"; MUTAGEN 844; /note="F->C: Strongly reduces production of IL1B in response to bacterial flagellin."; /evidence="ECO:0000269|PubMed:29182158"; MUTAGEN 847; /note="G->E: Strongly reduces production of IL1B in response to bacterial flagellin."; /evidence="ECO:0000269|PubMed:29182158"; MUTAGEN 847; /note="G->K: Nearly abolishes interaction with flagellin."; /evidence="ECO:0000269|PubMed:29146805"; MUTAGEN 848..849; /note="LW->AA: Strongly reduced interaction with flagellin."; /evidence="ECO:0000269|PubMed:29146805"; MUTAGEN 857; /note="S->Y: No effect on production of IL1B in response to bacterial flagellin."; /evidence="ECO:0000269|PubMed:29182158"; MUTAGEN 974..975; /note="YE->AA: Strongly reduced interaction with flagellin."; /evidence="ECO:0000269|PubMed:29146805"; MUTAGEN 1329..1330; /note="CR->AA: Reduced interaction with flagellin."; /evidence="ECO:0000269|PubMed:29146805"; MUTAGEN 1390..1403; /note="Missing: Abolishes production of IL1B in response to bacterial flagellin."; /evidence="ECO:0000269|PubMed:29182158
uniprot
proteins
pubmed
10486205
uniprot
proteins
pubmed
10501978
uniprot
proteins
pubmed
12526741
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18414036
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21874021
uniprot
proteins
pubmed
21918512
uniprot
proteins
pubmed
29146805
uniprot
proteins
pubmed
29182158
uniprot
proteins
pubmed
8975718
uniprot
proteins
sequence_length
1403
uniprot
proteins