Poglut1
entrez
288091
canonical
uniprot
G3V9D0
canonical
ensembl
ENSRNOG00000003014
resolver
ensp
ENSRNOP00000042736
resolver
genesymbol
Poglut1
resolver
genesymbol_syn
Ktelc1
resolver
uniprot
Q5BJN4
resolver
uniprot_entry
PGLT1_RAT
resolver
uniprot_entry
Q5BJN4_RAT
resolver
amino_acid_sequence
MERLSGCRLRPWMLLLLLFPVQGRQKDSGSKWKVFIDQINRALENYEPCSSQNCSCYHGVIEEDLTPFRGGISRKMMAEVVRRRLGTHYQIIKHRLFREDDCMFPSRCSGVEHFILEVIRRLPDMEMVINVRDYPQVPKWMEPTIPVFSFSKTSEYHDIMYPAWTFWEGGPAVWPLYPTGLGRWDLFREDLLRSAAQWPWEKKNSTAYFRGSRTSPERDPLILLSRKNPKLVDAEYTKNQAWKSMKDTLGKPAAKDVHLIDHCKYKYLFNFRGVAASFRFKHLFLCGSLVFHVGDEWVEFFYPQLKPWVHYIPVKTDLSDVQELLQFVKANDDLAQEIAKRGSQFIINHLQMDDITCYWENLLTEYSKFLSYNVTRRKDYYQIIPRRLKTEL
uniprot
proteins
ec_number
2.4.1.376
uniprot
proteins
ec_number
2.4.2.63
uniprot
proteins
function
FUNCTION: Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C. Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2 (By similarity). Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development (By similarity). Notch glucosylation does not affect Notch ligand binding (By similarity). Required during early development to promote gastrulation: acts by mediating O-glucosylation of CRB2, which is required for CRB2 localization to the cell membrane (By similarity). {ECO:0000250|UniProtKB:Q8BYB9, ECO:0000250|UniProtKB:Q8NBL1}.
uniprot
proteins
mass_dalton
46510
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:Q8BYB9}.
uniprot
proteins
protein_family
Glycosyltransferase 90 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
21949356
uniprot
proteins
sequence_length
392
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:21949356}.
uniprot
proteins