Smug1
entrez
315344
canonical
uniprot
Q811Q1
canonical
ensembl
ENSRNOG00000036842
resolver
ensembl
ENSRNOG00055028768
resolver
ensembl
ENSRNOG00060016257
resolver
ensembl
ENSRNOG00065023294
resolver
ensp
ENSRNOP00000069685
resolver
ensp
ENSRNOP00055041018
resolver
ensp
ENSRNOP00060022361
resolver
ensp
ENSRNOP00065032372
resolver
enst
ENSRNOT00000082149
resolver
enst
ENSRNOT00055049820
resolver
enst
ENSRNOT00060027833
resolver
enst
ENSRNOT00065039793
resolver
genesymbol
Smug1
resolver
uniprot_entry
SMUG1_RAT
resolver
amino_acid_sequence
MAVSQTFPPGPAHEPASALMEPCARSLAEGFLEEELRLNAELSQLQFPEPVGVIYNPVDYAWEPHRNYVTRYCQGPKEVLFLGMNPGPFGMAQTGVPFGEVNVVRDWLGIGGSVLSPPQEHPKRPVLGLECPQSEVSGARFWGFFRTLCGQPQVFFRHCFVHNLCPLLFLAPSGRNLTPADLPAKHREQLLSICDAALCRQVQLLGVRLVVGVGRLAEQRARRALAGLTPEVQVEGLLHPSPRSPQANKGWETAARERLQELGLLPLLTDEGSVRPTP
uniprot
proteins
ec_number
3.2.2.-
uniprot
proteins
function
FUNCTION: Recognizes base lesions in the genome and initiates base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA with a preference for single-stranded DNA substrates. The activity is greater toward mismatches (U/G) compared to matches (U/A). Excises uracil (U), 5-formyluracil (fU) and uracil derivatives bearing an oxidized group at C5 [5-hydroxyuracil (hoU) and 5-hydroxymethyluracil (hmU)] in ssDNA and dsDNA, but not analogous cytosine derivatives (5-hydroxycytosine and 5-formylcytosine), nor other oxidized bases. The activity is damage-specific and salt-dependent. The substrate preference is the following: ssDNA > dsDNA (G pair) = dsDNA (A pair) at low salt concentration, and dsDNA (G pair) > dsDNA (A pair) > ssDNA at high salt concentration. {ECO:0000269|PubMed:12718543}.
uniprot
proteins
mass_dalton
30562
uniprot
proteins
protein_family
SMUG1 family
uniprot
proteins
protein_family
Uracil-DNA glycosylase (UDG) superfamily
uniprot
proteins
pubmed
12718543
uniprot
proteins
sequence_length
278
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q53HV7}.
uniprot
proteins