Cx3cr1
entrez
171056
canonical
uniprot
P35411
canonical
ensembl
ENSRNOG00000018509
resolver
ensembl
ENSRNOG00055002443
resolver
ensembl
ENSRNOG00060023023
resolver
ensembl
ENSRNOG00065003671
resolver
ensp
ENSRNOP00000025019
resolver
ensp
ENSRNOP00000097085
resolver
ensp
ENSRNOP00000101892
resolver
ensp
ENSRNOP00000103606
resolver
ensp
ENSRNOP00000110768
resolver
ensp
ENSRNOP00000111344
resolver
ensp
ENSRNOP00000111560
resolver
ensp
ENSRNOP00000112291
resolver
ensp
ENSRNOP00055002930
resolver
ensp
ENSRNOP00055002933
resolver
ensp
ENSRNOP00060032915
resolver
ensp
ENSRNOP00060032934
resolver
ensp
ENSRNOP00065003865
resolver
ensp
ENSRNOP00065003868
resolver
enst
ENSRNOT00000025019
resolver
enst
ENSRNOT00000093935
resolver
enst
ENSRNOT00000137871
resolver
enst
ENSRNOT00000145045
resolver
enst
ENSRNOT00000145300
resolver
enst
ENSRNOT00000149437
resolver
enst
ENSRNOT00000150868
resolver
enst
ENSRNOT00000168395
resolver
enst
ENSRNOT00055003883
resolver
enst
ENSRNOT00055003886
resolver
enst
ENSRNOT00060039829
resolver
enst
ENSRNOT00060039855
resolver
enst
ENSRNOT00065005336
resolver
enst
ENSRNOT00065005339
resolver
genesymbol
Cx3cr1
resolver
genesymbol_syn
Rbs11
resolver
uniprot_entry
CX3C1_RAT
resolver
amino_acid_sequence
MPTSFPELDLENFEYDDSAEACYLGDIVAFGTIFLSIFYSLVFTFGLVGNLLVVLALTNSRKSKSITDIYLLNLALSDLLFVATLPFWTHYLISHEGLHNAMCKLTTAFFFIGFFGGIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVASPQFMFTKRKDNECLGDYPEVLQEIWPVLRNSEVNILGFVLPLLIMSFCYFRIVRTLFSCKNRKKARAIRLILLVVVVFFLFWTPYNIVIFLETLKFYNFFPSCGMKRDLRWALSVTETVAFSHCCLNPFIYAFAGEKFRRYLRHLYNKCLAVLCGRPVHAGFSTESQRSRQDSILSSLTHYTSEGEGSLLL
uniprot
proteins
function
FUNCTION: Receptor for the C-X3-C chemokine fractalkine (CX3CL1) present on many early leukocyte cells; CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis. CX3CR1-CX3CL1 signaling mediates cell migratory functions. Responsible for the recruitment of natural killer (NK) cells to inflamed tissues. Acts as a regulator of inflammation process leading to atherogenesis by mediating macrophage and monocyte recruitment to inflamed atherosclerotic plaques, promoting cell survival. Involved in airway inflammation by promoting interleukin 2-producing T helper (Th2) cell survival in inflamed lung. Involved in the migration of circulating monocytes to non-inflamed tissues, where they differentiate into macrophages and dendritic cells. Acts as a negative regulator of angiogenesis, probably by promoting macrophage chemotaxis. Plays a key role in brain microglia by regulating inflammatory response in the central nervous system (CNS) and regulating synapse maturation. Required to restrain the microglial inflammatory response in the CNS and the resulting parenchymal damage in response to pathological stimuli. Involved in brain development by participating in synaptic pruning, a natural process during which brain microglia eliminates extra synapses during postnatal development. Synaptic pruning by microglia is required to promote the maturation of circuit connectivity during brain development. Acts as an important regulator of the gut microbiota by controlling immunity to intestinal bacteria and fungi. Expressed in lamina propria dendritic cells in the small intestine, which form transepithelial dendrites capable of taking up bacteria in order to provide defense against pathogenic bacteria. Required to initiate innate and adaptive immune responses against dissemination of commensal fungi (mycobiota) component of the gut: expressed in mononuclear phagocytes (MNPs) and acts by promoting induction of antifungal IgG antibodies response to confer protection against disseminated C.albicans or C.auris infection (By similarity). Also acts as a receptor for C-C motif chemokine CCL26, inducing cell chemotaxis (By similarity). {ECO:0000250|UniProtKB:P49238, ECO:0000250|UniProtKB:Q9Z0D9}.
uniprot
proteins
mass_dalton
40327
uniprot
proteins
post_translational_modification
PTM: This protein is not N-glycosylated which is unusual for G protein-coupled receptors. {ECO:0000269|PubMed:8047298}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
8047298
uniprot
proteins
sequence_length
354
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P49238}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 33..60; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 71..91; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 105..126; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 144..168; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 197..216; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 233..257; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 275..298; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins