IL20
entrez
50604
canonical
uniprot
Q9NYY1
canonical
ensembl
ENSG00000162891
resolver
ensp
ENSP00000356065
resolver
ensp
ENSP00000375796
resolver
genesymbol
IL20
resolver
genesymbol_syn
ZCYTO10
resolver
hgnc
HGNC:6002
resolver
uniprot
Q17RB3
resolver
uniprot
Q2THG6
resolver
uniprot
Q96QZ6
resolver
uniprot_entry
IL20_HUMAN
resolver
uniprot_sec
Q17RB3
resolver
uniprot_sec
Q2THG6
resolver
uniprot_sec
Q96QZ6
resolver
amino_acid_sequence
MKASSLAFSLLSAAFYLLWTPSTGLKTLNLGSCVIATNLQEIRNGFSEIRGSVQAKDGNIDIRILRRTESLQDTKPANRCCLLRHLLRLYLDRVFKNYQTPDHYTLRKISSLANSFLTIKKDLRLCHAHMTCHCGEEAMKKYSQILSHFEKLEPQAAVVKALGELDILLQWMEETE
uniprot
proteins
function
FUNCTION: Pro-inflammatory and angiogenic cytokine mainly secreted by monocytes and skin keratinocytes that plays crucial roles in immune responses, regulation of inflammatory responses, hemopoiesis, as well as epidermal cell and keratinocyte differentiation (PubMed:17277128, PubMed:34403503). Enhances tissue remodeling and wound-healing activities and restores the homeostasis of epithelial layers during infection and inflammatory responses to maintain tissue integrity (PubMed:17277128). Affects multiple actin-mediated functions in activated neutrophils leading to inhibition of phagocytosis, granule exocytosis, and migration (PubMed:28424238). Exert its effects via the type I IL-20 receptor complex consisting of IL20RA and IL20RB (PubMed:11706020). Alternatively, can mediate its activity through a second receptor complex called type II IL-20 receptor complex composed of IL22RA1 and IL20RB (PubMed:11564763). Acts as an arteriogenic and vascular remodeling factory by activating a range of signaling processes including phosphorylations of JAK2 and STAT5 as well as activation of the serine and threonine kinases AKT and ERK1/2 (By similarity). Alternatively, can activate STAT3 phosphorylation and transcriptional activity in a JAK2, ERK1/2 and p38 MAPK-dependent manner in keratinocytes (PubMed:23614738). {ECO:0000250|UniProtKB:Q9JKV9, ECO:0000269|PubMed:11564763, ECO:0000269|PubMed:11706020, ECO:0000269|PubMed:16511554, ECO:0000269|PubMed:17277128, ECO:0000269|PubMed:23614738, ECO:0000269|PubMed:28424238, ECO:0000269|PubMed:34403503}.
uniprot
proteins
mass_dalton
20072
uniprot
proteins
protein_family
IL-10 family
uniprot
proteins
pubmed
11163236
uniprot
proteins
pubmed
11564763
uniprot
proteins
pubmed
11706020
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16511554
uniprot
proteins
pubmed
16709143
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16908179
uniprot
proteins
pubmed
17277128
uniprot
proteins
pubmed
22802649
uniprot
proteins
pubmed
23614738
uniprot
proteins
pubmed
28424238
uniprot
proteins
pubmed
34403503
uniprot
proteins
sequence_length
176
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:34403503}.
uniprot
proteins