Gna12
entrez
81663
canonical
uniprot
Q63210
canonical
ensembl
ENSRNOG00000001235
resolver
ensembl
ENSRNOG00055011424
resolver
ensembl
ENSRNOG00060029967
resolver
ensembl
ENSRNOG00065000095
resolver
ensp
ENSRNOP00000001654
resolver
ensp
ENSRNOP00055015608
resolver
ensp
ENSRNOP00060043300
resolver
ensp
ENSRNOP00065000155
resolver
enst
ENSRNOT00000001654
resolver
enst
ENSRNOT00055019375
resolver
enst
ENSRNOT00060052063
resolver
enst
ENSRNOT00065000156
resolver
genesymbol
Gna12
resolver
uniprot
Q45QM2
resolver
uniprot
Q45QM3
resolver
uniprot_entry
GNA12_RAT
resolver
uniprot_entry
Q45QM3_RAT
resolver
uniprot_sec
Q45QM2
resolver
amino_acid_sequence
MSGVVRTLSRCLLPAEAGARERRAGAARDAEREARRRSRDIDALLARERRAVRRLVKILLLGAGESGKSTFLKQMRIIHGREFDQKALLEFRDTIFDNILKGSRVLVDARDKLGIPWQHSENEKHGMFLMAFENKAGLPVEPATFQLYVPALSALWRDSGIREAFSRRSEFQLGESVKYFLDNLDRIGQLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMVDVGGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSIILFLNKMDLLVEKVKSVSIKKHFPDFKGDPHRLEDVQRYLVQCFDRKRRNRGKPLFHHFTTAIDTENIRFVFHAVKDTILQENLKDIMLQ
uniprot
proteins
function
FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:12176367, PubMed:21212405). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (By similarity). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (PubMed:21212405). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating pro-inflammatory cytokine production. Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (By similarity). Together with NAPA promotes CDH5 localization to plasma membrane (By similarity). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:12176367). {ECO:0000250|UniProtKB:P27600, ECO:0000250|UniProtKB:Q03113, ECO:0000269|PubMed:12176367, ECO:0000269|PubMed:21212405}.
uniprot
proteins
mass_dalton
44065
uniprot
proteins
mutagenesis
MUTAGEN 229; /note="Q->L: Constitutively active. Interacts with PPP5C, activates its phosphatase activity and translocates PPP5C to the plasma membrane."; /evidence="ECO:0000269|PubMed:12176367
uniprot
proteins
protein_family
G(12) subfamily
uniprot
proteins
protein_family
G-alpha family
uniprot
proteins
pubmed
12176367
uniprot
proteins
pubmed
21212405
uniprot
proteins
sequence_length
379
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12176367}; Peripheral membrane protein {ECO:0000269|PubMed:12176367}; Cytoplasmic side {ECO:0000305|PubMed:12176367}. Lateral cell membrane {ECO:0000250|UniProtKB:Q03113}; Peripheral membrane protein {ECO:0000269|PubMed:12176367}; Cytoplasmic side {ECO:0000305|PubMed:12176367}. Cytoplasm {ECO:0000250|UniProtKB:Q03113}. Note=Associated to the plasma membrane via lipid-anchor (By similarity). CDH1 enhances cell membrane localization (By similarity). {ECO:0000250|UniProtKB:P27600, ECO:0000250|UniProtKB:Q03113}.
uniprot
proteins