IL12A
entrez
3592
canonical
uniprot
P29459
canonical
ensembl
ENSG00000168811
resolver
ensp
ENSP00000303231
resolver
ensp
ENSP00000419046
resolver
ensp
ENSP00000420184
resolver
ensp
ENSP00000514529
resolver
enst
ENST00000305579
resolver
enst
ENST00000699704
resolver
genesymbol
IL12A
resolver
genesymbol_syn
NKSF1
resolver
hgnc
HGNC:5969
resolver
uniprot
A0A8Z5A9P2
resolver
uniprot
O60595
resolver
uniprot
Q96QZ1
resolver
uniprot_entry
A0A8Z5A9P2_HUMAN
resolver
uniprot_entry
IL12A_HUMAN
resolver
uniprot_entry
O60595_HUMAN
resolver
uniprot_sec
Q96QZ1
resolver
amino_acid_sequence
MCPARSLLLVATLVLLDHLSLARNLPVATPDPGMFPCLHHSQNLLRAVSNMLQKARQTLEFYPCTSEEIDHEDITKDKTSTVEACLPLELTKNESCLNSRETSFITNGSCLASRKTSFMMALCLSSIYEDLKMYQVEFKTMNAKLLMDPKRQIFLDQNMLAVIDELMQALNFNSETVPQKSSLEEPDFYKTKIKLCILLHAFRIRAVTIDRVMSYLNAS
uniprot
proteins
function
FUNCTION: Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine (PubMed:8605935, PubMed:8943050). IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity (PubMed:1673147, PubMed:1674604, PubMed:8605935). Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits (PubMed:8943050). Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2 (PubMed:7528775). In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes (PubMed:7638186). As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and also functions as an immune-suppressive cytokine (By similarity). Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers (PubMed:22306691). Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites (PubMed:22306691). {ECO:0000250|UniProtKB:P43431, ECO:0000269|PubMed:1673147, ECO:0000269|PubMed:1674604, ECO:0000269|PubMed:2204066, ECO:0000269|PubMed:22306691, ECO:0000269|PubMed:7528775, ECO:0000269|PubMed:7638186, ECO:0000269|PubMed:8605935, ECO:0000269|PubMed:8943050}.
uniprot
proteins
mass_dalton
24874
uniprot
proteins
protein_family
IL-6 superfamily
uniprot
proteins
pubmed
10899108
uniprot
proteins
pubmed
1374259
uniprot
proteins
pubmed
16548883
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
1673147
uniprot
proteins
pubmed
1674604
uniprot
proteins
pubmed
20691190
uniprot
proteins
pubmed
2204066
uniprot
proteins
pubmed
22306691
uniprot
proteins
pubmed
7528775
uniprot
proteins
pubmed
7638186
uniprot
proteins
pubmed
8605935
uniprot
proteins
pubmed
8943050
uniprot
proteins
pubmed
9342359
uniprot
proteins
sequence_length
219
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1674604, ECO:0000269|PubMed:9342359}.
uniprot
proteins