Rnf11
entrez
29864
canonical
uniprot
Q9QYK7
canonical
ensembl
ENSMUSG00000028557
resolver
ensp
ENSMUSP00000030284
resolver
ensp
ENSMUSP00000063798
resolver
enst
ENSMUST00000030284
resolver
enst
ENSMUST00000064167
resolver
genesymbol
Rnf11
resolver
genesymbol_syn
N4wbp2
resolver
genesymbol_syn
Sid1669
resolver
uniprot
B1AU36
resolver
uniprot
B1AU37
resolver
uniprot
Q9EQI1
resolver
uniprot_entry
RNF11_MOUSE
resolver
uniprot_sec
B1AU36
resolver
uniprot_sec
B1AU37
resolver
uniprot_sec
Q9EQI1
resolver
amino_acid_sequence
MGNCLKSPTSDDISLLHESQSDRASFGEGTEPDQEPPPPYQEQVPVPIYHPTPSQTRLATQLTEEEQIRIAQRIGLIQHLPKGVYDPGRDGSEKKIRECVICMMDFVYGDPIRFLPCMHIYHLDCIDDWLMRSFTCPSCMEPVDAALLSSYETN
uniprot
proteins
function
FUNCTION: Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.
uniprot
proteins
mass_dalton
17458
uniprot
proteins
mutagenesis
MUTAGEN 40; /note="Y->A: Abolishes interaction with NEDD4."; /evidence="ECO:0000269|PubMed:11042109
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated in the presence of ITCH, SMURF2 and UBE2D1, as well as WWP1. {ECO:0000250}.; PTM: Phosphorylation by PKB/AKT1 may accelerate degradation by the proteasome. {ECO:0000250}.; PTM: Acylation at both Gly-2 and Cys-4 is required for proper localization to the endosomes. {ECO:0000250}.
uniprot
proteins
pubmed
10673045
uniprot
proteins
pubmed
11042109
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19131965
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
154
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome {ECO:0000250}. Recycling endosome {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic, when unphosphorylated, and nuclear, when phosphorylated by PKB/AKT1. {ECO:0000250}.
uniprot
proteins