Il36rn
entrez
54450
canonical
uniprot
Q9QYY1
canonical
ensembl
ENSMUSG00000026983
resolver
ensp
ENSMUSP00000028360
resolver
ensp
ENSMUSP00000110134
resolver
ensp
ENSMUSP00000126028
resolver
enst
ENSMUST00000028360
resolver
enst
ENSMUST00000114490
resolver
enst
ENSMUST00000168941
resolver
genesymbol
Il36rn
resolver
genesymbol_syn
Fil1d
resolver
genesymbol_syn
Il1f5
resolver
genesymbol_syn
Il1h3
resolver
genesymbol_syn
Il1hy1
resolver
uniprot
Q9JIG2
resolver
uniprot_entry
I36RA_MOUSE
resolver
uniprot_sec
Q9JIG2
resolver
amino_acid_sequence
MMVLSGALCFRMKDSALKVLYLHNNQLLAGGLHAEKVIKGEEISVVPNRALDASLSPVILGVQGGSQCLSCGTEKGPILKLEPVNIMELYLGAKESKSFTFYRRDMGLTSSFESAAYPGWFLCTSPEADQPVRLTQIPEDPAWDAPITDFYFQQCD
uniprot
proteins
function
FUNCTION: Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2/IL-36R and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. {ECO:0000269|PubMed:17908936, ECO:0000269|PubMed:18284608, ECO:0000269|PubMed:21860022, ECO:0000269|PubMed:21965679}.
uniprot
proteins
mass_dalton
17136
uniprot
proteins
post_translational_modification
PTM: Removal of N-terminal methionine is necessary for full antagonistic activity. {ECO:0000269|PubMed:21965679}.
uniprot
proteins
protein_family
IL-1 family
uniprot
proteins
pubmed
10744718
uniprot
proteins
pubmed
11093146
uniprot
proteins
pubmed
11466363
uniprot
proteins
pubmed
12974628
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17908936
uniprot
proteins
pubmed
18284608
uniprot
proteins
pubmed
21860022
uniprot
proteins
pubmed
21965679
uniprot
proteins
sequence_length
156
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UBH0}. Secreted {ECO:0000250|UniProtKB:Q9UBH0}. Note=The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. {ECO:0000250|UniProtKB:Q9UBH0}.
uniprot
proteins