ASGR1
entrez
432
canonical
uniprot
P07306
canonical
ensembl
ENSG00000141505
resolver
ensp
ENSP00000269299
resolver
ensp
ENSP00000481182
resolver
ensp
ENSP00000533820
resolver
genesymbol
ASGR1
resolver
genesymbol_syn
CLEC4H1
resolver
hgnc
HGNC:742
resolver
uniprot
I3L1X1
resolver
uniprot
Q6FGQ5
resolver
uniprot_entry
ASGR1_HUMAN
resolver
uniprot_entry
Q6FGQ5_HUMAN
resolver
uniprot_sec
I3L1X1
resolver
amino_acid_sequence
MTKEYQDLQHLDNEESDHHQLRKGPPPPQPLLQRLCSGPRLLLLSLGLSLLLLVVVCVIGSQNSQLQEELRGLRETFSNFTASTEAQVKGLSTQGGNVGRKMKSLESQLEKQQKDLSEDHSSLLLHVKQFVSDLRSLSCQMAALQGNGSERTCCPVNWVEHERSCYWFSRSGKAWADADNYCRLEDAHLVVVTSWEEQKFVQHHIGPVNTWMGLHDQNGPWKWVDGTDYETGFKNWRPEQPDDWYGHGLGGGEDCAHFTDDGRWNDDVCQRPYRWVCETELDKASQEPPLL
uniprot
proteins
function
FUNCTION: Transmembrane protein predominantly expressed on hepatocytes that plays a key role in endocytosis of plasma glycoproteins that lack terminal sialic acid residues. Specifically recognizes terminal galactose and N-acetylgalactosamine residues, facilitating the clearance of desialylated glycoproteins from circulation. Plays thereby a role in a variety of physiological processes, such as removal of desialylated platelets, elimination of activated lymphocytes and maintenance of serum glycoprotein homeostasis (PubMed:25485912). Plays a role in the removal of desialylated platelets by activating a feedback loop regulating thrombopoietin (TPO) expression via the JAK2-STAT3 signaling pathway (PubMed:25485912). Contributes also to recognition and elimination of activated lymphocytes by hepatocytes that can act as cytotoxic effectors (PubMed:21656538). May also play a physiological role in the regulatory network of lipid homeostasis (By similarity). Upon ligand binding, the receptor-ligand complex is internalized and trafficked to a sorting organelle, where dissociation occurs. The receptor is then recycled back to the cell surface. {ECO:0000250|UniProtKB:P34927, ECO:0000269|PubMed:12171918, ECO:0000269|PubMed:21656538, ECO:0000269|PubMed:25485912}.; FUNCTION: (Microbial infection) Plays an essential role in ACE2-independent SARS-CoV-2 entry by acting as alternate receptor. {ECO:0000269|PubMed:34837059}.
uniprot
proteins
mass_dalton
33186
uniprot
proteins
mutagenesis
MUTAGEN 36; /note="C->S: Complete loss of palmitoylation."; /evidence="ECO:0000269|PubMed:12171918
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on a cytoplasmic Ser residue.; PTM: Palmitoylated at Cys-36. Palmitoylation is essential for coated pit-mediated endocytosis, dissociation, and delivery of ligand to lysosomes. {ECO:0000269|PubMed:11543633}.
uniprot
proteins
pubmed
10891274
uniprot
proteins
pubmed
11543633
uniprot
proteins
pubmed
12171918
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
20886072
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21656538
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25485912
uniprot
proteins
pubmed
27155063
uniprot
proteins
pubmed
2982798
uniprot
proteins
pubmed
34837059
uniprot
proteins
pubmed
3753585
uniprot
proteins
pubmed
8943311
uniprot
proteins
sequence_length
291
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform H1a]: Cell membrane {ECO:0000269|PubMed:12171918}; Single-pass type II membrane protein.; SUBCELLULAR LOCATION: [Isoform H1b]: Secreted {ECO:0000269|PubMed:20886072}.
uniprot
proteins
transmembrane_region
TRANSMEM 41..61; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000305
uniprot
proteins