Mysm1
entrez
320713
canonical
uniprot
Q69Z66
canonical
ensembl
ENSMUSG00000062627
resolver
ensp
ENSMUSP00000075269
resolver
ensp
ENSMUSP00000182136
resolver
ensp
ENSMUSP00000345385
resolver
genesymbol
Mysm1
resolver
genesymbol_syn
Kiaa1915
resolver
uniprot
A2AJE3
resolver
uniprot
B9EKJ6
resolver
uniprot
Q3TPV7
resolver
uniprot
Q8BRP5
resolver
uniprot
Q8C4N1
resolver
uniprot_entry
MYSM1_MOUSE
resolver
uniprot_sec
A2AJE3
resolver
uniprot_sec
B9EKJ6
resolver
uniprot_sec
Q3TPV7
resolver
uniprot_sec
Q8BRP5
resolver
uniprot_sec
Q8C4N1
resolver
amino_acid_sequence
MEAEEADVDVEGDVAAAAQPGNDESTASVFQDHYLDSTWRRENGCLPWTLDSTISDENRAIIEKMLLEEEYYLSNKSLPGKFWVNQKEDNKKYTNSLQKSSKAMVDSPAKPASHSVKWTVEEKELFEQGLAKFGRRWTKIATLLKSRTVLQVKSYARQYFKNKVKWDVEKETPTQKSSSDLQVKNKDDRTKAWAAACLRGSADPCLNAVKIEKLSDDEDVDITDELDELTSQTSQNSGSHLTLDVPNSKMYTTNQGELCQEGPLAKSSGESLQNVKQGEGEACSSSEIASWAEKQKSTDKNSAELNEKYNKVVEEHTLHRGEVREEAKHSPSPEPCERQDSSGNEMLLPPCQIEEENHEGEELKPPEQEVEIDRNVIQEEEKQAIPEFFEGRQTKTPERYLKIRNYILDQWEICKPKYLNKTSVRPGLKNCGDVNCIGRIHTYLELIGAINFGCEQAVYNRPQPLDKVRAADRKDAEAAYQLAWRLQSMRTRRRRVRDPWGNWCDAKDLEGQTFEHLSVEEMARRKEEEKCKPIKFSKASKLPKSSLDPFQLIPCNFFSEEKQEPFQVKVAAEALLIMNLHAHVSMAEVIGLLGGRYSEADKVLEVCAAEPCNSLSTGLQCEMDPVSQTQASETLALRGYSVIGWYHSHPAFDPNPSLRDIDTQAKYQSYFSRGGAKFIGMIVSPYNRSNPLPYSQITCLVISEEVSPDGTYRLPYKFEVQQMLEEPQWELVFEKTRWIIEKYRLSNSSVPMDRIFRRDSDLTCLQKLLECLRKTLSKVANCFIAEEFLTQIENLFLSNYKSKEENGLAEEDSTKELFM
uniprot
proteins
ec_number
3.4.19.-
uniprot
proteins
function
FUNCTION: Metalloprotease with deubiquitinase activity that plays important regulator roles in hematopoietic stem cell function, blood cell production and immune response (PubMed:26474655, PubMed:27895164, PubMed:30405132). Participates in the normal programming of B-cell responses to antigen after the maturation process (PubMed:27895164). Within the cytoplasm, plays critical roles in the repression of innate immunity and autoimmunity (PubMed:26474655, PubMed:30405132). Removes 'Lys-63'-linked polyubiquitins from TRAF3 and TRAF6 complexes (PubMed:26474655). Attenuates NOD2-mediated inflammation and tissue injury by promoting 'Lys-63'-linked deubiquitination of RIPK2 component (PubMed:30405132). Suppresses the CGAS-STING1 signaling pathway by cleaving STING1 'Lys-63'-linked ubiquitin chains (PubMed:33086059). In the nucleus, acts as a hematopoietic transcription regulator derepressing a range of genes essential for normal stem cell differentiation including EBF1 and PAX5 in B-cells, ID2 in NK-cell progenitor or FLT3 in dendritic cell precursors (PubMed:22169041, PubMed:24062447, PubMed:25217698, PubMed:26348977). Deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, leading to dissociation of histone H1 from the nucleosome (By similarity). {ECO:0000250|UniProtKB:Q5VVJ2, ECO:0000269|PubMed:22169041, ECO:0000269|PubMed:24062447, ECO:0000269|PubMed:25217698, ECO:0000269|PubMed:26348977, ECO:0000269|PubMed:26474655, ECO:0000269|PubMed:27895164, ECO:0000269|PubMed:30405132}.
uniprot
proteins
mass_dalton
93475
uniprot
proteins
protein_family
MYSM1 subfamily
uniprot
proteins
protein_family
Peptidase M67A family
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22169041
uniprot
proteins
pubmed
24062447
uniprot
proteins
pubmed
25217698
uniprot
proteins
pubmed
26348977
uniprot
proteins
pubmed
26474655
uniprot
proteins
pubmed
27895164
uniprot
proteins
pubmed
30405132
uniprot
proteins
pubmed
33086059
uniprot
proteins
sequence_length
819
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26474655, ECO:0000269|PubMed:30405132}. Cytoplasm {ECO:0000269|PubMed:26474655, ECO:0000269|PubMed:30405132}. Note=Localizes to the cytoplasm in response to bacterial infection. {ECO:0000269|PubMed:26474655}.
uniprot
proteins