Kl
entrez
16591
canonical
uniprot
O35082
canonical
ensembl
ENSMUSG00000058488
resolver
ensp
ENSMUSP00000077899
resolver
genesymbol
Kl
resolver
uniprot
B2RR78
resolver
uniprot
O70175
resolver
uniprot
O70621
resolver
uniprot_entry
KLOT_MOUSE
resolver
uniprot_sec
B2RR78
resolver
uniprot_sec
O70175
resolver
uniprot_sec
O70621
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by D-saccharic acid 1,4-lactone and taurocholic acid. {ECO:0000269|PubMed:14701853}.
uniprot
proteins
amino_acid_sequence
MLARAPPRRPPRLVLLRLLLLHLLLLALRARCLSAEPGQGAQTWARFARAPAPEAAGLLHDTFPDGFLWAVGSAAYQTEGGWRQHGKGASIWDTFTHHSGAAPSDSPIVVAPSGAPSPPLSSTGDVASDSYNNVYRDTEGLRELGVTHYRFSISWARVLPNGTAGTPNREGLRYYRRLLERLRELGVQPVVTLYHWDLPQRLQDTYGGWANRALADHFRDYAELCFRHFGGQVKYWITIDNPYVVAWHGYATGRLAPGVRGSSRLGYLVAHNLLLAHAKVWHLYNTSFRPTQGGRVSIALSSHWINPRRMTDYNIRECQKSLDFVLGWFAKPIFIDGDYPESMKNNLSSLLPDFTESEKRLIRGTADFFALSFGPTLSFQLLDPNMKFRQLESPNLRQLLSWIDLEYNHPPIFIVENGWFVSGTTKRDDAKYMYYLKKFIMETLKAIRLDGVDVIGYTAWSLMDGFEWHRGYSIRRGLFYVDFLSQDKELLPKSSALFYQKLIEDNGFPPLPENQPLEGTFPCDFAWGVVDNYVQVDTTLSQFTDPNVYLWDVHHSKRLIKVDGVVAKKRKPYCVDFSAIRPQITLLREMRVTHFRFSLDWALILPLGNQTQVNHTVLHFYRCMISELVHANITPVVALWQPAAPHQGLPHALAKHGAWENPHTALAFADYANLCFKELGHWVNLWITMNEPNTRNMTYRAGHHLLRAHALAWHLYDDKFRAAQKGKISIALQADWIEPACPFSQNDKEVAERVLEFDIGWLAEPIFGSGDYPRVMRDWLNQKNNFLLPYFTEDEKKLVRGSFDFLAVSHYTTILVDWEKEDPMKYNDYLEVQEMTDITWLNSPSQVAVVPWGLRKVLNWLRFKYGDLPMYVTANGIDDDPHAEQDSLRIYYIKNYVNEALKAYVLDDINLCGYFAYSLSDRSAPKSGFYRYAANQFEPKPSMKHYRKIIDSNGFLGSGTLGRFCPEEYTVCTECGFFQTRKSLLVFISFLVFTFIISLALIFHYSKKGQRSYK
uniprot
proteins
ec_number
3.2.1.31
uniprot
proteins
function
FUNCTION: Exhibits beta-glucuronidase activity in vitro despite lacking canonical catalytic Glu residues of glycosyl hydrolase 1 family enzymes (PubMed:14701853). Hydrolyzes steroid beta-D-glucuronides including estradiol-3-beta-D-glucuronide, estrone-3-beta-D-glucuronide and estriol-3-beta-D-glucuronide (PubMed:14701853). Essential for the interaction between FGF23 and FGFR1 and for FGF23-mediated regulation of renal vitamin D and phosphate homeostasis (PubMed:17086194). {ECO:0000269|PubMed:14701853, ECO:0000269|PubMed:17086194}.; FUNCTION: [Klotho peptide]: The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling. {ECO:0000269|PubMed:16123266}.
uniprot
proteins
mass_dalton
116398
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:15135068}.; PTM: Proteolytic cleavage of the membrane-bound form releases a soluble extracellular domain, also referred to as the Klotho peptide. {ECO:0000269|PubMed:15135068}.
uniprot
proteins
protein_family
Glycosyl hydrolase 1 family
uniprot
proteins
protein_family
Klotho subfamily
uniprot
proteins
pubmed
10631108
uniprot
proteins
pubmed
11016890
uniprot
proteins
pubmed
11095966
uniprot
proteins
pubmed
11411791
uniprot
proteins
pubmed
12204354
uniprot
proteins
pubmed
14528024
uniprot
proteins
pubmed
14701853
uniprot
proteins
pubmed
15135068
uniprot
proteins
pubmed
15485693
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15665504
uniprot
proteins
pubmed
16123266
uniprot
proteins
pubmed
17086194
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9363890
uniprot
proteins
pubmed
9537505
uniprot
proteins
sequence_length
1014
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:10631108, ECO:0000269|PubMed:12204354, ECO:0000269|PubMed:15135068, ECO:0000269|PubMed:9363890}; Single-pass type I membrane protein {ECO:0000305|PubMed:9363890}. Apical cell membrane {ECO:0000269|PubMed:15665504}; Single-pass type I membrane protein {ECO:0000305|PubMed:15665504}. Note=Isoform 1 shedding leads to a soluble peptide. {ECO:0000269|PubMed:16123266}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:10631108, ECO:0000269|PubMed:15135068}.; SUBCELLULAR LOCATION: [Klotho peptide]: Secreted {ECO:0000269|PubMed:16123266}.
uniprot
proteins
transmembrane_region
TRANSMEM 983..1003; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins