Shank3
entrez
59312
canonical
uniprot
Q9JLU4
canonical
ensembl
ENSRNOG00000052296
resolver
ensp
ENSRNOP00000071295
resolver
ensp
ENSRNOP00000080578
resolver
enst
ENSRNOT00000092413
resolver
genesymbol
Shank3
resolver
genesymbol_syn
Prosap2
resolver
uniprot
A0A8I5ZTC4
resolver
uniprot
Q9WUY7
resolver
uniprot
Q9WV47
resolver
uniprot_entry
A0A8I5ZTC4_RAT
resolver
uniprot_entry
SHAN3_RAT
resolver
uniprot_sec
Q9WUY7
resolver
uniprot_sec
Q9WV47
resolver
amino_acid_sequence
MDGPGASAVVVRVGIPDLQQTKCLRLDPTAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQDYPPNLDTPLPYLEFRYKRRVYAQNLIDDKQFAKLHTKANLKKFMDYVQLHSTDKVARLLDKGLDPNFHDPDSGECPLSLAAQLDNATDLLKVLRNGGAHLDFRTRDGLTAVHCATRQRNAGALTTLLDLGASPDYKDSRGLTPLYHSALGGGDALCCELLLHDHAQLGTTDENGWQEIHQACRFGHVQHLEHLLFYGANMGAQNASGNTALHICALYNQESCARVLLFRGANKDVRNYNSQTAFQVAIIAGNFELAEVIKTHKDSDVVPFRETPSYAKRRRLAGPSGLASPRPLQRSASDINLKGDQPAASPGPTLRSLPHQLLLQRLQEEKDRDRDGEQENDISGPSAGRGGHSKISPSGPGGSGPAPGPGPASPAPPAPPPRGPKRKLYSAVPGRKFIAVKAHSPQGEGEIPLHRGEAVKVLSIGEGGFWEGTVKGRTGWFPADCVEEVQMRQYDTRHETREDRTKRLFRHYTVGSYDSLTSHSDYVIDDKVAILQKRDHEGFGFVLRGAKAETPIEEFTPTPAFPALQYLESVDVEGVAWKAGLRTGDFLIEVNGVNVVKVGHKQVVGLIRQGGNRLVMKVVSVTRKPEEDSARRRAPPPPKRAPSTTLTLRSKSMTAELEELASIRRRKGEKLDEILAVAAEPTLRPDIADADSRAATVKQRPTSRRITPAEISSLFERQGLPGPEKLPGSLRKGIPRTKSVGEDEKLASLLEGRFPRSTSMQDTVREGRGIPPPPQTAPPPPPAPYYFDSGPPPTFSPPPPPPGRAYDTVRSSFKPGLEARLGAGAAGLYDSGTPLGPLPYPERQKRARSMIILQDSAPEVGDVPRPAPAATPPERPKRRPRPSGPDSPYANLGAFSASLFAPSKPQRRKSPLVKQLQVEDAQERAALAVGSPGPVGGSFAREPSPTHRGPRPGGLDYSSGEGLGLTFGGPSPGPVKERRLEERRRSTVFLSVGAIEGSPPSADLPSLQPSRSIDERLLGTGATTGRDLLLPSPVSALKPLVGGPSLGPSGSTFIHPLTGKPLDPSSPLALALAARERALASQTPSRSPTPVHSPDADRPGPLFVDVQTRDSERGPLASPAFSPRSPAWIPVPARREAEKPTREERKSPEDKKSMILSVLDTSLQRPAGLIVVHATSNGQEPNRLGAEEERPGTPELAPTPMQAAAVAEPMPSPRAQPPGSIPADPGPGQGSSEEEPELVFAVNLPPAQLSSSDEETREELARIGLVPPPEEFANGILLATPPPGPGPLPTTVPSPASGKPSSELPPAPESAADSGVEEADTRSSSDPHLETTSTISTVSSMSTLSSESGELTDTHTSFADGHTFLLEKPPVPPKPKLKSPLGKGPVTFRDPLLKQSSDSELMAQQHHATSTGLTSAAGPARPRYLFQRRSKLWGDPVESRGLPGPEDDKPTVISELSSRLQQLNKDTRSLGEEPVGGLGSLLDPAKKSPIAAARCAVVPSAGWLFSSLGELSTISAQRSPGGPGGGASYSVRPSGRYPVARRAPSPVKPASLERVEGLGAGVGGAGRPFGLTPPTILKSSSLSIPHEPKEVRFVVRSVSARSRSPSPSPLPSPSPGSGPSAGPRRPFQQKPLQLWSKFDVGDWLESIHLGEHRDRFEDHEIEGAHLPALTKEDFVELGVTRVGHRMNIERALRQLDGS
uniprot
proteins
function
FUNCTION: Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. {ECO:0000269|PubMed:21606927, ECO:0000269|PubMed:21795692, ECO:0000269|PubMed:23100419, ECO:0000269|PubMed:23897824, ECO:0000269|PubMed:24089484}.
uniprot
proteins
mass_dalton
186376
uniprot
proteins
mutagenesis
MUTAGEN 12; /note="R->C: Disrupts postsynaptic AMPA and NMDA receptor-mediated synaptic transmission as well as transsynaptic signaling and spine maturation."; /evidence="ECO:0000269|PubMed:21606927, ECO:0000269|PubMed:23100419"; MUTAGEN 68; /note="L->P: Slightly increases interaction with SHARPIN and SPTAN1. No effect on localization."; /evidence="ECO:0000269|PubMed:23897824"; MUTAGEN 300; /note="R->C: Disrupts postsynaptic AMPA and NMDA receptor-mediated synaptic transmission as well as transsynaptic signaling and spine maturation. Slightly decreases interaction with SHARPIN and SPTAN1. No effect on localization."; /evidence="ECO:0000269|PubMed:21606927, ECO:0000269|PubMed:23100419, ECO:0000269|PubMed:23897824"; MUTAGEN 321; /note="Q->R: Disrupts postsynaptic AMPA and NMDA receptor-mediated synaptic transmission as well as transsynaptic signaling and spine maturation. Disrupts axonal growth cone motility. Slightly increases interaction with SHARPIN and SPTAN1. No effect on localization."; /evidence="ECO:0000269|PubMed:21606927, ECO:0000269|PubMed:23100419, ECO:0000269|PubMed:23897824"; MUTAGEN 677; /note="P->A: Strongly decreases interaction with ABI1."; /evidence="ECO:0000269|PubMed:17304222"; MUTAGEN 678; /note="P->A: Almost abolishes interaction with ABI1."; /evidence="ECO:0000269|PubMed:17304222"; MUTAGEN 679; /note="P->A: Abolishes interaction with ABI1."; /evidence="ECO:0000269|PubMed:17304222"; MUTAGEN 680; /note="P->A: Abolishes interaction with ABI1."; /evidence="ECO:0000269|PubMed:17304222"; MUTAGEN 684; /note="P->A: Abolishes interaction with ABI1."; /evidence="ECO:0000269|PubMed:17304222"; MUTAGEN 1311; /note="P->L: Abolishes interaction with HOMER1 isoform 3."; /evidence="ECO:0000269|PubMed:10433269"; MUTAGEN 1314; /note="F->C: Abolishes interaction with HOMER1 isoform 3."; /evidence="ECO:0000269|PubMed:10433269
uniprot
proteins
protein_family
SHANK family
uniprot
proteins
pubmed
10433268
uniprot
proteins
pubmed
10433269
uniprot
proteins
pubmed
10527873
uniprot
proteins
pubmed
10806096
uniprot
proteins
pubmed
10958799
uniprot
proteins
pubmed
15014124
uniprot
proteins
pubmed
16439662
uniprot
proteins
pubmed
16522626
uniprot
proteins
pubmed
17304222
uniprot
proteins
pubmed
21606927
uniprot
proteins
pubmed
21795692
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23100419
uniprot
proteins
pubmed
23897824
uniprot
proteins
pubmed
24089484
uniprot
proteins
sequence_length
1740
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Postsynaptic density. Cell projection, dendritic spine. Note=In neuronal cells, extends into the region subjacent to the PSD.
uniprot
proteins