Polr2m
entrez
28015
canonical
uniprot
Q6P6I6
canonical
ensembl
ENSMUSG00000032199
resolver
ensp
ENSMUSP00000034720
resolver
ensp
ENSMUSP00000132335
resolver
genesymbol
Polr2m
resolver
genesymbol_syn
Grinl1a
resolver
uniprot
Q8CG13
resolver
uniprot
Q9CXJ7
resolver
uniprot
Q9DCQ9
resolver
uniprot_entry
GRL1A_MOUSE
resolver
uniprot_sec
Q8CG13
resolver
uniprot_sec
Q9CXJ7
resolver
uniprot_sec
Q9DCQ9
resolver
amino_acid_sequence
MFSLPRGFEPPAPEDLGRQSSAELRERLRRQERLLRNEKFICKLPDKGKKISDTVAKLKAAISEREEVRGRSELFHPVSVDCKLRQKATTRADTDVDKAQSSDLMLDTSSLDPDCSSIDIKSSKSTSETQGPTHLTHRGNEETLEAGYTVNSSPAAHIRARAPSSEVKEHLPQHSVSSQEEEISSSIDSLFITKLQKITIADQSEPSEENTSTENFPELQSETPKKPHYMKVLEMRARNPVPPPHKFKTNVLPTQQSDSPSHCQRGQSPASSEEQRRRARQHLDDITAARLLPLHHLPAQLLSIEESLALQREQKQNYEEMQAKLAAQKLAERLNIKMQSYNPEGESSGRYREVRDEADAQSSDEC
uniprot
proteins
function
FUNCTION: Appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. May play a role in the Mediator complex-dependent regulation of transcription activation. Acts as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II. {ECO:0000250|UniProtKB:P0CAP2}.
uniprot
proteins
mass_dalton
41237
uniprot
proteins
post_translational_modification
PTM: Dephosphorylated at Ser-268 by the PNUTS-PP1 complex, promoting RNA polymerase II transcription pause-release. {ECO:0000250|UniProtKB:P0CAP2}.
uniprot
proteins
protein_family
GRINL1 family
uniprot
proteins
pubmed
12063408
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
366
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins