Csrp3
entrez
117505
canonical
uniprot
P50463
canonical
ensembl
ENSRNOG00000014327
resolver
ensp
ENSRNOP00000019310
resolver
enst
ENSRNOT00000019311
resolver
genesymbol
Csrp3
resolver
genesymbol_syn
Clp
resolver
genesymbol_syn
Mlp
resolver
uniprot
G3V7U0
resolver
uniprot_entry
CSRP3_RAT
resolver
uniprot_entry
G3V7U0_RAT
resolver
amino_acid_sequence
MPNWGGGAKCGACDKTVYHAEEIQCNGRSFHKTCFHCMACRKALDSTTVAAHESEIYCKVCYGRKYGPKGIGFGQGAGCLSTDTGEHLGLQFQQSPKPARAATTSNPSKFSAKFGESEKCPRCGKSVYAAEKVMGGGKPWHKTCFPCAICGKSLESTNVTDKDGELYCKVCYAKNFGPTGIGFGGLTHQVEKKE
uniprot
proteins
function
FUNCTION: Positive regulator of myogenesis. Acts as a cofactor for myogenic bHLH transcription factors such as MYOD1, and probably MYOG and MYF6. Enhances the DNA-binding activity of the MYOD1:TCF3 isoform E47 complex and may promote formation of a functional MYOD1:TCF3 isoform E47:MEF2A complex involved in myogenesis (PubMed:7954791, PubMed:9234731). Plays a crucial and specific role in the organization of cytosolic structures in cardiomyocytes. Could play a role in mechanical stretch sensing. May be a scaffold protein that promotes the assembly of interacting proteins at Z-line structures. It is essential for calcineurin anchorage to the Z line. Required for stress-induced calcineurin-NFAT activation. The role in regulation of cytoskeleton dynamics by association with CFL2 is reported conflictingly. Proposed to contribute to the maintenance of muscle cell integrity through an actin-based mechanism. Can directly bind to actin filaments, cross-link actin filaments into bundles without polarity selectivity and protect them from dilution- and cofilin-mediated depolymerization; the function seems to involve its self-association. In vitro can inhibit PKC/PRKCA activity. Proposed to be involved in cardiac stress signaling by down-regulating excessive PKC/PRKCA signaling (By similarity). {ECO:0000250|UniProtKB:P50461, ECO:0000250|UniProtKB:P50462, ECO:0000269|PubMed:7954791, ECO:0000269|PubMed:9234731}.
uniprot
proteins
mass_dalton
20803
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKC/PRKCA. {ECO:0000250|UniProtKB:P50461}.
uniprot
proteins
pubmed
10751147
uniprot
proteins
pubmed
12127981
uniprot
proteins
pubmed
16963613
uniprot
proteins
pubmed
18258855
uniprot
proteins
pubmed
19376126
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7954791
uniprot
proteins
pubmed
9234731
uniprot
proteins
sequence_length
194
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16963613, ECO:0000269|PubMed:19376126, ECO:0000269|PubMed:9234731}. Cytoplasm {ECO:0000269|PubMed:16963613, ECO:0000269|PubMed:19376126, ECO:0000269|PubMed:9234731}. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:P50462}. Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:P50461}. Note=Nucleocytoplasmic shuttling protein (PubMed:19376126). Mainly cytoplasmic. In the Z line, found associated with GLRX3 (By similarity). {ECO:0000250|UniProtKB:P50462, ECO:0000269|PubMed:19376126}.
uniprot
proteins