S100a1
entrez
20193
canonical
uniprot
P56565
canonical
ensembl
ENSMUSG00000044080
resolver
ensp
ENSMUSP00000058237
resolver
enst
ENSMUST00000060738
resolver
genesymbol
S100a1
resolver
uniprot
F6R0J2
resolver
uniprot
O88949
resolver
uniprot
Q91V77
resolver
uniprot_entry
F6R0J2_MOUSE
resolver
uniprot_entry
Q91V77_MOUSE
resolver
uniprot_entry
S10A1_MOUSE
resolver
uniprot_sec
O88949
resolver
amino_acid_sequence
MGSELESAMETLINVFHAHSGQEGDKYKLSKKELKDLLQTELSGFLDVQKDADAVDKVMKELDENGDGEVDFKEYVVLVAALTVACNNFFWETS
uniprot
proteins
function
FUNCTION: Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed:11909974, PubMed:16952982). In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes. These changes allow interactions with specific target proteins and modulate their activity. Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase (PubMed:17438143). Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole (By similarity). {ECO:0000250|UniProtKB:P23297, ECO:0000269|PubMed:11909974, ECO:0000269|PubMed:16952982, ECO:0000269|PubMed:17438143}.
uniprot
proteins
mass_dalton
10505
uniprot
proteins
post_translational_modification
PTM: Glutathionylated; glutathionylation increases affinity to calcium about 10-fold. {ECO:0000250|UniProtKB:P23297}.
uniprot
proteins
protein_family
S-100 family
uniprot
proteins
pubmed
11909974
uniprot
proteins
pubmed
16952982
uniprot
proteins
pubmed
17438143
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
3276520
uniprot
proteins
pubmed
9920416
uniprot
proteins
sequence_length
94
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P23297}. Sarcoplasmic reticulum {ECO:0000269|PubMed:3276520}. Mitochondrion {ECO:0000269|PubMed:17438143}.
uniprot
proteins