FOXA3
entrez
3171
canonical
uniprot
P55318
canonical
ensembl
ENSG00000170608
resolver
ensp
ENSP00000304004
resolver
enst
ENST00000302177
resolver
genesymbol
FOXA3
resolver
genesymbol_syn
HNF3G
resolver
genesymbol_syn
TCF3G
resolver
hgnc
HGNC:5023
resolver
uniprot
A9LYI5
resolver
uniprot
Q53F16
resolver
uniprot
Q9UMW9
resolver
uniprot_entry
FOXA3_HUMAN
resolver
uniprot_sec
A9LYI5
resolver
uniprot_sec
Q53F16
resolver
uniprot_sec
Q9UMW9
resolver
amino_acid_sequence
MLGSVKMEAHDLAEWSYYPEAGEVYSPVTPVPTMAPLNSYMTLNPLSSPYPPGGLPASPLPSGPLAPPAPAAPLGPTFPGLGVSGGSSSSGYGAPGPGLVHGKEMPKGYRRPLAHAKPPYSYISLITMAIQQAPGKMLTLSEIYQWIMDLFPYYRENQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWALHPSSGNMFENGCYLRRQKRFKLEEKVKKGGSGAATTTRNGTGSAASTTTPAATVTSPPQPPPPAPEPEAQGGEDVGALDCGSPASSTPYFTGLELPGELKLDAPYNFNHPFSINNLMSEQTPAPPKLDVGFGGYGAEGGEPGVYYQGLYSRSLLNAS
uniprot
proteins
function
FUNCTION: Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC1 promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis. {ECO:0000250, ECO:0000269|PubMed:12695546}.
uniprot
proteins
mass_dalton
37140
uniprot
proteins
pubmed
10899756
uniprot
proteins
pubmed
12695546
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19706729
uniprot
proteins
pubmed
19919681
uniprot
proteins
pubmed
8332212
uniprot
proteins
pubmed
8499623
uniprot
proteins
pubmed
9369482
uniprot
proteins
sequence_length
350
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:19706729}.
uniprot
proteins