Pou2af1
entrez
18985
canonical
uniprot
Q64693
canonical
ensembl
ENSMUSG00000032053
resolver
ensp
ENSMUSP00000034554
resolver
enst
ENSMUST00000034554
resolver
genesymbol
Pou2af1
resolver
genesymbol_syn
Obf-1
resolver
uniprot
Q542H4
resolver
uniprot_entry
OBF1_MOUSE
resolver
uniprot_entry
Q542H4_MOUSE
resolver
amino_acid_sequence
MLWQKSTAPEQAPAPPRPYQGVRVKEPVKELLRRKRGHTSVGAAGPPTAVVLPHQPLATYSTVGPSCLDMEVSASTVTEEGTLCAGWLSQPAPATLQPLAPWTPYTEYVSHEAVSCPYSTDMYVQPVCPSYTVVGPSSVLTYASPPLITNVTPRSTATPAVGPQLEGPEHQAPLTYFPWPQPLSTLPTSSLQYQPPAPTLSGPQFVQLPISIPEPVLQDMDDPRRAISSLTIDKLLLEEEESNTYELNHTLSVEGF
uniprot
proteins
function
FUNCTION: Transcriptional coactivator that specifically associates with either POU2F1/OCT1 or POU2F2/OCT2. It boosts the POU2F1/OCT1 mediated promoter activity and to a lesser extent, that of POU2F2/OCT2. It recognizes the POU domains of POU2F1/OCT1 and POU2F2/OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers (PubMed:23045607). Regulates IL6 expression in B cells as POU2F2/OCT2 coactivator (PubMed:23045607). {ECO:0000269|PubMed:23045607}.
uniprot
proteins
mass_dalton
27692
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation. {ECO:0000250|UniProtKB:Q16633}.
uniprot
proteins
protein_family
POU2AF family
uniprot
proteins
pubmed
23045607
uniprot
proteins
pubmed
8530384
uniprot
proteins
pubmed
8657574
uniprot
proteins
pubmed
8868069
uniprot
proteins
sequence_length
256
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins