Atp6v1f
entrez
116664
canonical
uniprot
P50408
canonical
ensembl
ENSRNOG00055022311
resolver
ensembl
ENSRNOG00060027198
resolver
ensembl
ENSRNOG00065025658
resolver
ensp
ENSRNOP00055031212
resolver
ensp
ENSRNOP00060039251
resolver
ensp
ENSRNOP00065036298
resolver
enst
ENSRNOT00055038337
resolver
enst
ENSRNOT00060047179
resolver
enst
ENSRNOT00065044216
resolver
genesymbol
Atp6v1f
resolver
genesymbol_syn
Atp6s14
resolver
genesymbol_syn
Vatf
resolver
uniprot_entry
VATF_RAT
resolver
amino_acid_sequence
MAGRGKLIAVIGDEDTVTGFLLGGIGELNKNRHPNFLVVEKDTTINEIEDTFRQFLNRDDIGIILINQYIAEMVRHALDAHQRSIPAVLEIPSKEHPYDAAKDSILRRAKGMFTAEDLR
uniprot
proteins
function
FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32165585). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (PubMed:32165585). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity). {ECO:0000250|UniProtKB:Q16864, ECO:0000269|PubMed:32165585}.
uniprot
proteins
mass_dalton
13370
uniprot
proteins
protein_family
V-ATPase F subunit family
uniprot
proteins
pubmed
32165585
uniprot
proteins
pubmed
8621738
uniprot
proteins
sequence_length
119
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:32165585}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269|PubMed:32165585}; Peripheral membrane protein {ECO:0000305}.
uniprot
proteins