Ranbp3
entrez
71810
canonical
uniprot
Q9CT10
canonical
ensembl
ENSMUSG00000002372
resolver
ensp
ENSMUSP00000002445
resolver
ensp
ENSMUSP00000156588
resolver
ensp
ENSMUSP00000181967
resolver
ensp
ENSMUSP00000181969
resolver
ensp
ENSMUSP00000181974
resolver
ensp
ENSMUSP00000181989
resolver
enst
ENSMUST00000002445
resolver
enst
ENSMUST00000233319
resolver
genesymbol
Ranbp3
resolver
uniprot
A0A3B2WCL5
resolver
uniprot
A6H6I9
resolver
uniprot
Q3TIS4
resolver
uniprot
Q3U2G4
resolver
uniprot
Q3UYG7
resolver
uniprot_entry
A0A3B2WCL5_MOUSE
resolver
uniprot_entry
RANB3_MOUSE
resolver
uniprot_sec
A6H6I9
resolver
uniprot_sec
Q3TIS4
resolver
uniprot_sec
Q3U2G4
resolver
uniprot_sec
Q3UYG7
resolver
amino_acid_sequence
MADLANEEKPAVAPSVFVFQKDKGQKRSAGSSSPEAGEDSDHEDGNYCPPVKRERTSSLTHSEEKSSGFRLKPPTLIHGQAPSAGLPSQKPREQQRGVLRPAVLQAPQPKVLSQTVPSSGTNGVSMPADCTGPATSVSPENLTQRSPSESAEETHTLEEKVPQKTPHGTSEEGHCEEEQAAPQAFVFGQNLRDRVKLMNENASVADVDSAAHPSSETPSATNYFLQYISSSADNATHSADNSTKFVFGQNMSERVLSPPKLNEANSDTSRETTHAQSGSESSSQEAAPKKESLAESAAAYTKATAWTCLLEKVEVITGEEAESNVLQIQCKLFVFDKTSQSWVERGRGLLRLNDMASTDDGTLQSRLVMRTQGSLRLILNTKLWAQMQMDKASEKSIRITATDAEDQGVKVFLISASSKDTGQLYAALHHRILALRSRAEQEQEAKAPPPEPGATRATEEEDSDEDAVLAPSGVTGAGTGDEGDGQAPGST
uniprot
proteins
function
FUNCTION: Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. {ECO:0000250|UniProtKB:Q9H6Z4}.
uniprot
proteins
mass_dalton
52573
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-58 promotes its import into the nucleus. {ECO:0000250|UniProtKB:Q9H6Z4}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
491
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H6Z4}. Nucleus {ECO:0000250|UniProtKB:Q9H6Z4}. Note=Nuclear import is promoted by phosphorylation at Ser-58 and is dependent on KPNA4. {ECO:0000250|UniProtKB:Q9H6Z4}.
uniprot
proteins