IRF1
entrez
3659
canonical
uniprot
P10914
canonical
ensembl
ENSG00000125347
resolver
ensp
ENSP00000245414
resolver
ensp
ENSP00000384406
resolver
ensp
ENSP00000505720
resolver
ensp
ENSP00000506148
resolver
ensp
ENSP00000635435
resolver
enst
ENST00000245414
resolver
enst
ENST00000405885
resolver
enst
ENST00000680139
resolver
enst
ENST00000680903
resolver
enst
ENST00000965376
resolver
genesymbol
IRF-1
resolver
genesymbol
IRF1
resolver
hgnc
HGNC:6116
resolver
uniprot
A0A7P0T9M1
resolver
uniprot
A0A7P0TAL6
resolver
uniprot
Q6FHN8
resolver
uniprot
Q96GG7
resolver
uniprot
X5D3F6
resolver
uniprot_entry
A0A7P0T9M1_HUMAN
resolver
uniprot_entry
A0A7P0TAL6_HUMAN
resolver
uniprot_entry
IRF1_HUMAN
resolver
uniprot_entry
Q6FHN8_HUMAN
resolver
uniprot_entry
X5D3F6_HUMAN
resolver
uniprot_sec
Q96GG7
resolver
activity_regulation
ACTIVITY REGULATION: Activated by MYD88. {ECO:0000250|UniProtKB:P15314}.
uniprot
proteins
amino_acid_sequence
MPITRMRMRPWLEMQINSNQIPGLIWINKEEMIFQIPWKHAAKHGWDINKDACLFRSWAIHTGRYKAGEKEPDPKTWKANFRCAMNSLPDIEEVKDQSRNKGSSAVRVYRMLPPLTKNQRKERKSKSSRDAKSKAKRKSCGDSSPDTFSDGLSSSTLPDDHSSYTVPGYMQDLEVEQALTPALSPCAVSSTLPDWHIPVEVVPDSTSDLYNFQVSPMPSTSEATTDEDEEGKLPEDIMKLLEQSEWQPTNVDGKGYLLNEPGVQPTSVYGDFSCKEEPEIDSPGGDIGLSLQRVFTDLKNMDATWLDSLLTPVRLPSIQAIPCAP
uniprot
proteins
disease_involvement
DISEASE: Gastric cancer (GASC) [MIM:613659]: A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. {ECO:0000269|PubMed:10395927, ECO:0000269|PubMed:9679752}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; DISEASE: Immunodeficiency 117 (IMD117) [MIM:620668]: An autosomal recessive immunologic disorder characterized by increased susceptibility to disseminated mycobacterial infection apparent in early childhood, after exposure to weakly virulent mycobacteria. Affected individuals develop mycobacterial disease after BCG (bacille Calmette-Guerin) vaccination. Immunologic workup shows impaired development of myeloid and lymphoid cell subsets that secrete and respond to gamma-interferon. {ECO:0000269|PubMed:36736301}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses (PubMed:15226432, PubMed:15509808, PubMed:17516545, PubMed:17942705, PubMed:18497060, PubMed:19404407, PubMed:19851330, PubMed:22367195, PubMed:32385160). Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage (PubMed:15226432, PubMed:15509808, PubMed:17516545, PubMed:17942705, PubMed:18497060, PubMed:19404407, PubMed:19851330, PubMed:22367195, PubMed:7687740). Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:15226432, PubMed:15509808, PubMed:17516545, PubMed:17942705, PubMed:18497060, PubMed:19404407, PubMed:19851330, PubMed:21389130, PubMed:22367195). Has an essential role in IFNG-dependent immunity to mycobacteria (PubMed:36736301). Competes with the transcriptional repressor ZBED2 for binding to a common consensus sequence in gene promoters (PubMed:32385160). Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, RIGI, TNFSF10/TRAIL, ZBP1, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as GBP2, GBP5 and NOS2/INOS; anti-proliferative response, such as p53/TP53, LOX and CDKN1A; apoptosis, such as BBC3/PUMA, CASP1, CASP7 and CASP8; immune response, such as IL7, IL12A/B and IL15, PTGS2/COX2 and CYBB; DNA damage responses and DNA repair, such as POLQ/POLH; MHC class I expression, such as TAP1, PSMB9/LMP2, PSME1/PA28A, PSME2/PA28B and B2M and MHC class II expression, such as CIITA; metabolic enzymes, such as ACOD1/IRG1 (PubMed:15226432, PubMed:15509808, PubMed:17516545, PubMed:17942705, PubMed:18497060, PubMed:19404407, PubMed:19851330, PubMed:22367195). Represses genes involved in anti-proliferative response, such as BIRC5/survivin, CCNB1, CCNE1, CDK1, CDK2 and CDK4 and in immune response, such as FOXP3, IL4, ANXA2 and TLR4 (PubMed:18641303, PubMed:22200613). Stimulates p53/TP53-dependent transcription through enhanced recruitment of EP300 leading to increased acetylation of p53/TP53 (PubMed:15509808, PubMed:18084608). Plays an important role in immune response directly affecting NK maturation and activity, macrophage production of IL12, Th1 development and maturation of CD8+ T-cells (PubMed:11244049, PubMed:11846971, PubMed:11846974, PubMed:16932750). Also implicated in the differentiation and maturation of dendritic cells and in the suppression of regulatory T (Treg) cells development (PubMed:11244049, PubMed:11846971, PubMed:11846974, PubMed:16932750). Acts as a tumor suppressor and plays a role not only in antagonism of tumor cell growth but also in stimulating an immune response against tumor cells (PubMed:20049431). {ECO:0000269|PubMed:15226432, ECO:0000269|PubMed:15509808, ECO:0000269|PubMed:17516545, ECO:0000269|PubMed:17942705, ECO:0000269|PubMed:18084608, ECO:0000269|PubMed:18497060, ECO:0000269|PubMed:18641303, ECO:0000269|PubMed:19404407, ECO:0000269|PubMed:19851330, ECO:0000269|PubMed:21389130, ECO:0000269|PubMed:22200613, ECO:0000269|PubMed:22367195, ECO:0000269|PubMed:32385160, ECO:0000269|PubMed:36736301, ECO:0000269|PubMed:7687740, ECO:0000303|PubMed:11244049, ECO:0000303|PubMed:11846971, ECO:0000303|PubMed:11846974, ECO:0000303|PubMed:16932750, ECO:0000303|PubMed:20049431}.
uniprot
proteins
mass_dalton
36502
uniprot
proteins
mutagenesis
MUTAGEN 67; /note="A->P: No effect on transcriptional activity."; /evidence="ECO:0000269|PubMed:36736301"; MUTAGEN 78; /note="K->R: Loss of acetylation. Partial loss of DNA-binding and transcriptional activity."; /evidence="ECO:0000269|PubMed:22367195"; MUTAGEN 275; /note="K->R: Some loss of sumoylation. Partial inhibition of acetylation and activity. Abolishes sumoylation, diminished ubiquitination, higher resistance to degradation, and increased apoptotic activity; when associated with R-299."; /evidence="ECO:0000269|PubMed:17942705"; MUTAGEN 299; /note="K->R: Large loss of sumoylation. Abolishes sumoylation, diminished ubiquitination, higher resistance to degradation, and increased apoptotic activity; when associated with R-275."; /evidence="ECO:0000269|PubMed:17942705
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CK2 and this positively regulates its activity. {ECO:0000269|PubMed:10094406}.; PTM: Sumoylation represses the transcriptional activity and displays enhanced resistance to protein degradation (PubMed:17942705). Sumoylated by UBE2I/UBC9 and SUMO1 (By similarity). Inactivates the tumor suppressor activity (PubMed:17942705). Elevated levels in tumor cells (PubMed:17942705). Major site is Lys-275 (PubMed:17942705). Sumoylation is enhanced by PIAS3 (By similarity). Desumoylated by SENP1 in tumor cells and appears to compete with ubiquitination on C-terminal sites (PubMed:17942705). {ECO:0000250|UniProtKB:P15314, ECO:0000269|PubMed:17942705}.; PTM: Ubiquitinated in a SPOP-dependent manner (PubMed:37622993). Appears to compete with sumoylation on C-terminal sites. {ECO:0000269|PubMed:17942705, ECO:0000269|PubMed:37622993}.
uniprot
proteins
protein_family
IRF family
uniprot
proteins
pubmed
10094406
uniprot
proteins
pubmed
10395927
uniprot
proteins
pubmed
11244049
uniprot
proteins
pubmed
11846971
uniprot
proteins
pubmed
11846974
uniprot
proteins
pubmed
1382447
uniprot
proteins
pubmed
15226432
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15509808
uniprot
proteins
pubmed
16932750
uniprot
proteins
pubmed
17516545
uniprot
proteins
pubmed
17942705
uniprot
proteins
pubmed
18084608
uniprot
proteins
pubmed
18497060
uniprot
proteins
pubmed
18641303
uniprot
proteins
pubmed
19404407
uniprot
proteins
pubmed
19851330
uniprot
proteins
pubmed
20049431
uniprot
proteins
pubmed
21389130
uniprot
proteins
pubmed
22200613
uniprot
proteins
pubmed
22367195
uniprot
proteins
pubmed
2726461
uniprot
proteins
pubmed
32385160
uniprot
proteins
pubmed
3409321
uniprot
proteins
pubmed
36736301
uniprot
proteins
pubmed
37622993
uniprot
proteins
pubmed
7507207
uniprot
proteins
pubmed
7687740
uniprot
proteins
pubmed
8438156
uniprot
proteins
pubmed
9679752
uniprot
proteins
sequence_length
325
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:37622993}. Cytoplasm {ECO:0000250|UniProtKB:P15314}. Note=MYD88-associated IRF1 migrates into the nucleus more efficiently than non-MYD88-associated IRF1. {ECO:0000250|UniProtKB:P15314}.
uniprot
proteins