Gzmb
entrez
14939
canonical
uniprot
P04187
canonical
ensembl
ENSMUSG00000015437
resolver
ensp
ENSMUSP00000015581
resolver
enst
ENSMUST00000015581
resolver
genesymbol
Gzmb
resolver
genesymbol_syn
Ctla-1
resolver
genesymbol_syn
Ctla1
resolver
uniprot
Q3TZH4
resolver
uniprot_entry
GRAB_MOUSE
resolver
uniprot_entry
Q3TZH4_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Inactivated by the serine protease inhibitor diisopropylfluorophosphate. {ECO:0000250|UniProtKB:P10144}.
uniprot
proteins
amino_acid_sequence
MKILLLLLTLSLASRTKAGEIIGGHEVKPHSRPYMALLSIKDQQPEAICGGFLIREDFVLTAAHCEGSIINVTLGAHNIKEQEKTQQVIPMVKCIPHPDYNPKTFSNDIMLLKLKSKAKRTRAVRPLNLPRRNVNVKPGDVCYVAGWGRMAPMGKYSNTLQEVELTVQKDRECESYFKNRYNKTNQICAGDPKTKRASFRGDSGGPLVCKKVAAGIVSYGYKDGSPPRAFTKVSSFLSWIKKTMKSS
uniprot
proteins
ec_number
3.4.21.79
uniprot
proteins
function
FUNCTION: Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse (PubMed:3555842, PubMed:35705808). It cleaves after Asp (PubMed:35705808). Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death (By similarity). Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution (By similarity). Cleaves caspase-3 and -9 (CASP3 and CASP9, respectively) to give rise to active enzymes mediating apoptosis (PubMed:35705808). Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair (PubMed:35705808). {ECO:0000250|UniProtKB:P10144, ECO:0000269|PubMed:3555842, ECO:0000269|PubMed:35705808}.
uniprot
proteins
mass_dalton
27470
uniprot
proteins
protein_family
Granzyme subfamily
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
3090449
uniprot
proteins
pubmed
3237717
uniprot
proteins
pubmed
3264185
uniprot
proteins
pubmed
3518058
uniprot
proteins
pubmed
3555842
uniprot
proteins
pubmed
35705808
uniprot
proteins
pubmed
8043949
uniprot
proteins
sequence_length
247
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P10144}. Cytolytic granule {ECO:0000269|PubMed:3555842}. Note=Delivered into the target cell by perforin. {ECO:0000250|UniProtKB:P10144}.
uniprot
proteins