APIP
entrez
51074
canonical
uniprot
Q96GX9
canonical
ensembl
ENSG00000149089
resolver
ensp
ENSP00000379133
resolver
ensp
ENSP00000607778
resolver
ensp
ENSP00000635135
resolver
genesymbol
APIP
resolver
hgnc
HGNC:17581
resolver
uniprot
A8K9D3
resolver
uniprot
Q6PJX6
resolver
uniprot
Q8WVU2
resolver
uniprot
Q96HK2
resolver
uniprot
Q9Y318
resolver
uniprot_entry
MTNB_HUMAN
resolver
uniprot_sec
A8K9D3
resolver
uniprot_sec
Q6PJX6
resolver
uniprot_sec
Q8WVU2
resolver
uniprot_sec
Q96HK2
resolver
uniprot_sec
Q9Y318
resolver
amino_acid_sequence
MSGCDAREGDCCSRRCGAQDKEHPRYLIPELCKQFYHLGWVTGTGGGISLKHGDEIYIAPSGVQKERIQPEDMFVCDINEKDISGPSPSKKLKKSQCTPLFMNAYTMRGAGAVIHTHSKAAVMATLLFPGREFKITHQEMIKGIKKCTSGGYYRYDDMLVVPIIENTPEEKDLKDRMAHAMNEYPDSCAVLVRRHGVYVWGETWEKAKTMCECYDYLFDIAVSMKKVGLDPSQLPVGENGIV
uniprot
proteins
ec_number
4.2.1.109
uniprot
proteins
function
FUNCTION: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. {ECO:0000255|HAMAP-Rule:MF_03116, ECO:0000269|PubMed:15262985, ECO:0000269|PubMed:22837397, ECO:0000269|PubMed:23285211, ECO:0000269|PubMed:24367089}.
uniprot
proteins
mass_dalton
27125
uniprot
proteins
mutagenesis
MUTAGEN 84; /note="S->A,D: Does not affect ability of cells to grow in media where methionine is replaced by 5-methylthioadenosine; when associated with A,D-87 and A,D-89."; /evidence="ECO:0000269|PubMed:23285211"; MUTAGEN 87; /note="S->A,D: Does not affect ability of cells to grow in media where methionine is replaced by 5-methylthioadenosine; when associated with A,D-84 and A,D-89."; /evidence="ECO:0000269|PubMed:23285211"; MUTAGEN 89; /note="S->A,D: Does not affect ability of cells to grow in media where methionine is replaced by 5-methylthioadenosine; when associated with A,D-84 and A,D-87."; /evidence="ECO:0000269|PubMed:23285211"; MUTAGEN 96; /note="Q->A: Mildly reduced enzyme activity."; /evidence="ECO:0000269|PubMed:24367089"; MUTAGEN 97; /note="C->A: Acts as a dominant negative mutant; unable to use 5'-methylthioadenosine as source of methionine. Does not affect the ability to bind CASP1 and to inhibit cell death induced by CASP9 overexpression."; /evidence="ECO:0000269|PubMed:22837397"; MUTAGEN 97; /note="C->A: Almost complete loss of enzyme activity. Abolishes protection against pyroptosis. No effect on anti-apoptotic activity."; /evidence="ECO:0000269|PubMed:24367089"; MUTAGEN 115; /note="H->A: Almost complete loss of enzyme activity. Abolishes protection against pyroptosis. No effect on anti-apoptotic activity."; /evidence="ECO:0000269|PubMed:24367089"; MUTAGEN 115; /note="H->A: Impaired ability of cells to grow in media where methionine is replaced by 5-methylthioadenosine; when associated with A-117 and A-195. Unable to inhibit both CASP1 and CASP9 mediated cell death."; /evidence="ECO:0000269|PubMed:22837397, ECO:0000269|PubMed:23285211"; MUTAGEN 117; /note="H->A: Impaired ability of cells to grow in media where methionine is replaced by 5-methylthioadenosine; when associated with A-115 and A-195."; /evidence="ECO:0000269|PubMed:23285211"; MUTAGEN 139; /note="E->A: Almost complete loss of enzyme activity. Abolishes protection against pyroptosis. No effect on anti-apoptotic activity."; /evidence="ECO:0000269|PubMed:24367089"; MUTAGEN 195; /note="H->A: Impaired ability of cells to grow in media where methionine is replaced by 5-methylthioadenosine; when associated with 87-A--A-89."; /evidence="ECO:0000269|PubMed:23285211
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6. {ECO:0000255|HAMAP-Rule:MF_03116, ECO:0000269|PubMed:23285211, ECO:0000269|PubMed:24367089}.
uniprot
proteins
protein_family
Aldolase class II family
uniprot
proteins
protein_family
MtnB subfamily
uniprot
proteins
pubmed
10810093
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15262985
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22837397
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23285211
uniprot
proteins
pubmed
24367089
uniprot
proteins
sequence_length
242
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03116, ECO:0000269|PubMed:15262985, ECO:0000269|PubMed:23285211}.
uniprot
proteins