Mymk
entrez
66139
canonical
uniprot
Q9D1N4
canonical
ensembl
ENSMUSG00000009214
resolver
ensp
ENSMUSP00000009358
resolver
ensp
ENSMUSP00000128491
resolver
enst
ENSMUST00000009358
resolver
enst
ENSMUST00000163967
resolver
genesymbol
Mymk
resolver
genesymbol_syn
Tmem8c
resolver
uniprot
E9QA72
resolver
uniprot_entry
E9QA72_MOUSE
resolver
uniprot_entry
MYMK_MOUSE
resolver
amino_acid_sequence
MGTVVAKLLLPTLSSLAFLPTVSIATKRRFYMEAMVYLFTMFFVAFSHACDGPGLSVLCFMRRDILEYFSIYGTALSMWVSLMALADFDEPQRSTFTMLGVLTIAVRTFHDRWGYGVYSGPIGTATLIIAVKWLKKMKEKKGLYPDKSIYTQQIGPGLCFGALALMLRFFFEEWDYTYVHSFYHCALAMSFVLLLPKVNKKAGNAGAPAKLTFSTLCCTCV
uniprot
proteins
function
FUNCTION: Myoblast-specific protein that mediates myoblast fusion, an essential step for the formation of multi-nucleated muscle fibers (PubMed:23868259, PubMed:28386024, PubMed:28681861, PubMed:30197239). Actively participates in the membrane fusion reaction by mediating the mixing of cell membrane lipids (hemifusion) upstream of MYMX (PubMed:30197239). Acts independently of MYMX (PubMed:30197239). Involved in skeletal muscle regeneration in response to injury by mediating the fusion of satellite cells, a population of muscle stem cells, with injured myofibers (PubMed:25085416). Also involved in skeletal muscle hypertrophy, probably by mediating the fusion of satellite cells with myofibers (PubMed:28186492). {ECO:0000269|PubMed:23868259, ECO:0000269|PubMed:25085416, ECO:0000269|PubMed:28186492, ECO:0000269|PubMed:28386024, ECO:0000269|PubMed:28681861, ECO:0000269|PubMed:30197239}.
uniprot
proteins
mass_dalton
24792
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="G->A: Does not affect subcellular localization."; /evidence="ECO:0000269|PubMed:28860190"; MUTAGEN 215..221; /note="TLCCTCV->AAAAAAA: Abolished localization to the Golgi apparatus."; /evidence="ECO:0000269|PubMed:28860190"; MUTAGEN 215..221; /note="TLCCTCV->AACCACA: Does not affect subcellular localization."; /evidence="ECO:0000269|PubMed:28860190"; MUTAGEN 216..221; /note="LCCTCV->ACCACA: Does not affect subcellular localization."; /evidence="ECO:0000269|PubMed:28860190"; MUTAGEN 217..220; /note="CCTC->AATA,SSTS: Abolished localization to the Golgi apparatus."; /evidence="ECO:0000269|PubMed:28860190"; MUTAGEN 217..218; /note="CC->SS: Abolished localization to the Golgi apparatus."; /evidence="ECO:0000269|PubMed:28860190"; MUTAGEN 218..220; /note="CTC->STS: Abolished localization to the Golgi apparatus."; /evidence="ECO:0000269|PubMed:28860190"; MUTAGEN 219..221; /note="TCV->AAA: Does not affect subcellular localization."; /evidence="ECO:0000269|PubMed:28860190
uniprot
proteins
post_translational_modification
PTM: Palmitoylated at the C-terminus; palmitoylation promotes localization to the Golgi apparatus. {ECO:0000269|PubMed:28860190}.
uniprot
proteins
protein_family
TMEM8 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23868259
uniprot
proteins
pubmed
25085416
uniprot
proteins
pubmed
28186492
uniprot
proteins
pubmed
28386024
uniprot
proteins
pubmed
28579197
uniprot
proteins
pubmed
28681861
uniprot
proteins
pubmed
28860190
uniprot
proteins
pubmed
30197239
uniprot
proteins
sequence_length
221
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23868259, ECO:0000269|PubMed:28860190}; Multi-pass membrane protein {ECO:0000269|PubMed:23868259}. Golgi apparatus membrane {ECO:0000269|PubMed:28860190}; Multi-pass membrane protein {ECO:0000269|PubMed:28860190}. Note=Localizes on the plasma membrane of myoblasts, where it mediates myoblasts fusion (PubMed:23868259, PubMed:28860190). Also localizes in the Golgi apparatus and post-Golgi following palmitoylation; the role of Golgi localization is unclear (PubMed:28860190). {ECO:0000269|PubMed:23868259, ECO:0000269|PubMed:28860190}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 30..50; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 65..85; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 94..110; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 114..134; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 154..174; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 176..196; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins