Q8K4Q9
uniprot
Q8K4Q9
canonical
amino_acid_sequence
MGDWSFLGNILEEVNEHSTVIGRVWLTVLFIFRILILGTAAEFVWGDEQSDFVCNTQQPGCENVCYDEAFPISHIRLWVLQIIFVSTPSLMYVGHAVHHVRMEEKRKDREAEELCQQSRSNGGERVPIAPDQASIRKSSSSSKGTKKFRLEGTLLRTYVCHIIFKTLFEVGFIVGHYFLYGFRILPLYRCSRWPCPNVVDCFVSRPTEKTIFILFMLSVAFVSLFLNIMEMSHLGMKGIRSAFKRPAEQPLGEIAEKSLHSIAVSSIQKAKGYQLLEEEKIVSHYFPLTEVGMVETSPLSAKPFSQFEEKIGTGPLADMSRGYQETLPSYAQVGAQEVEREEQPVEEAVEPEVGEKKQEAEKVAPEGQETVAVPDGEKVETPGVGKDDEKEELQAEKVTKQGLSAEKAPTLCPELTTDDNRPLSRLSKASSRARSDDLTI
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Gja8 are the cause of cataract. {ECO:0000269|PubMed:12356818}.
uniprot
proteins
function
FUNCTION: Structural component of eye lens gap junctions. Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane. Small molecules and ions diffuse from one cell to a neighboring cell via the central pore. {ECO:0000250|UniProtKB:P55917}.
uniprot
proteins
mass_dalton
49401
uniprot
proteins
protein_family
Alpha-type (group II) subfamily
uniprot
proteins
protein_family
Connexin family
uniprot
proteins
pubmed
12356818
uniprot
proteins
pubmed
1325220
uniprot
proteins
sequence_length
440
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P55917}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55917}. Cell junction, gap junction {ECO:0000250|UniProtKB:P55917}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P55917"; TRANSMEM 72..92; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P55917"; TRANSMEM 162..182; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P55917"; TRANSMEM 211..231; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P55917
uniprot
proteins