Stmn2
entrez
84510
canonical
uniprot
P21818
canonical
ensembl
ENSRNOG00000011705
resolver
ensembl
ENSRNOG00055001898
resolver
ensembl
ENSRNOG00060001848
resolver
ensembl
ENSRNOG00065020105
resolver
ensp
ENSRNOP00000015720
resolver
ensp
ENSRNOP00055002311
resolver
ensp
ENSRNOP00060001854
resolver
ensp
ENSRNOP00065027119
resolver
enst
ENSRNOT00000015720
resolver
enst
ENSRNOT00055003059
resolver
enst
ENSRNOT00060002844
resolver
enst
ENSRNOT00065033898
resolver
genesymbol
Stmn2
resolver
genesymbol_syn
Scg10
resolver
genesymbol_syn
Scgn10
resolver
uniprot
Q9ERH2
resolver
uniprot_entry
STMN2_RAT
resolver
uniprot_sec
Q9ERH2
resolver
amino_acid_sequence
MAKTAMAYKEKMKELSMLSLICSCFYPEPRNINIYTYDDMEVKQINKRASGQAFELILKPPSPISEAPRTLASPKKKDLSLEEIQKKLEAAEGRRKSQEAQVLKQLAEKREHEREVLQKALEENNNFSKMAEEKLILKMEQIKENREANLAAIIERLQEKERHAAEVRRNKELQVELSG
uniprot
proteins
function
FUNCTION: Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone. {ECO:0000269|PubMed:16618812, ECO:0000269|PubMed:21297631, ECO:0000269|PubMed:9012855}.
uniprot
proteins
mass_dalton
20756
uniprot
proteins
mutagenesis
MUTAGEN 62; /note="S->A: Partial loss of phosphorylation. Complete loss of phosphorylation by MAPK8, increased microtubule solubility, and reduced neurite length; when associated with A-73."; /evidence="ECO:0000269|PubMed:16618812"; MUTAGEN 62; /note="S->D: Increased microtubule stability but no effect on neurite length; when associated with A-73."; /evidence="ECO:0000269|PubMed:16618812"; MUTAGEN 73; /note="S->A: Partial loss of phosphorylation. Complete loss of phosphorylation by MAPK8, increased microtubule solubility, and reduced neurite length; when associated with A-62."; /evidence="ECO:0000269|PubMed:16618812"; MUTAGEN 73; /note="S->D: Increased microtubule stability but no effect on neurite length; when associated with A-62."; /evidence="ECO:0000269|PubMed:16618812
uniprot
proteins
post_translational_modification
PTM: Sumoylated. {ECO:0000250}.; PTM: Phosphorylated by MAPK9 and MAPK10 in the developing brain cortex (By similarity). Phosphorylated mostly by MAPK8. {ECO:0000250, ECO:0000269|PubMed:16618812}.; PTM: N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15 (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Stathmin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16618812
uniprot
proteins
pubmed
21215777
uniprot
proteins
pubmed
21297631
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
3272176
uniprot
proteins
pubmed
9012855
uniprot
proteins
sequence_length
179
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, perinuclear region. Cell projection, growth cone. Cell projection, axon. Membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus. Endosome. Cell projection, lamellipodium {ECO:0000250}. Note=Colocalized with CIB1 in the cell body, neuritis and growth cones of neurons. Colocalized with CIB1 to the leading edge of lamellipodia (By similarity). Associated with punctate structures in the perinuclear cytoplasm, axons, and growth cones of developing neurons. Exists in both soluble and membrane-bound forms. Colocalized with CIB1 in neurites of developing hippocampal primary neurons. {ECO:0000250}.
uniprot
proteins