Stam2
entrez
56324
canonical
uniprot
O88811
canonical
ensembl
ENSMUSG00000055371
resolver
ensp
ENSMUSP00000099820
resolver
ensp
ENSMUSP00000278598
resolver
genesymbol
Stam2
resolver
genesymbol_syn
Hbp
resolver
uniprot
A2AU00
resolver
uniprot
Q3TGH8
resolver
uniprot
Q8C8Y4
resolver
uniprot_entry
Q3TGH8_MOUSE
resolver
uniprot_entry
STAM2_MOUSE
resolver
uniprot_sec
A2AU00
resolver
uniprot_sec
Q8C8Y4
resolver
amino_acid_sequence
MPLFTANPFEQDVEKATNEYNTTEDWSLIMDICDRVGSTPSGAKDCLKAIMKRVNHKVPHVALQALTLLGACVANCGKIFHLEVCSRDFATEVRSVIKNKAHPKVCEKLKSLMVEWSEEFQKDPQFSLISATIKSMKEEGVTFPSAGSQTVAAAAKNGTSLNKNKEDEDIAKAIELSLQEQKQQYTETKALYPPAESQLNNKAARRVRALYDFEAVEDNELTFKHGELITVLDDSDANWWQGENHRGTGLFPSNFVTTDLSTEVETATVDKLNVIDDDVEEIKKSEPEPVYIDEGKMDRALQILQSIDPKESKPDSQDLLDLEDVCQQMGPMIDEKLEEIDRKHSELSELNVKVLEALDLYNKLVNEAPVYSVYSKLHPAHYPPAAAGVPVQTYPVQSHGGNYLGHGIHQVSVAQNYNLGPDPMGSLRSLPPNMNSVTAHTVQPPYLSTGQDTVSNPSYMNQSSRLQAAAGTAAYTQPVGMSTDVSSFQNTASGLPQLAGFPVAVPAPVAAQPQASYHQQPLL
uniprot
proteins
function
FUNCTION: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). {ECO:0000250, ECO:0000269|PubMed:12972556}.
uniprot
proteins
mass_dalton
57455
uniprot
proteins
mutagenesis
MUTAGEN 176; /note="L->A: Loss of interaction with UBQLN1; when associated with A-177."; /evidence="ECO:0000269|PubMed:16159959"; MUTAGEN 177; /note="S->A: Loss of interaction with UBQLN1; when associated with A-176."; /evidence="ECO:0000269|PubMed:16159959
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in response to IL-2, GM-CSF, EGF and PDGF. {ECO:0000250}.
uniprot
proteins
protein_family
STAM family
uniprot
proteins
pubmed
10651905
uniprot
proteins
pubmed
10982817
uniprot
proteins
pubmed
12446783
uniprot
proteins
pubmed
12551915
uniprot
proteins
pubmed
12972556
uniprot
proteins
pubmed
13129930
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16159959
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
523
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10651905, ECO:0000269|PubMed:12551915}. Early endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
uniprot
proteins