Mtnr1a
entrez
17773
canonical
uniprot
Q61184
canonical
ensembl
ENSMUSG00000054764
resolver
ensp
ENSMUSP00000069872
resolver
enst
ENSMUST00000067984
resolver
genesymbol
Mtnr1a
resolver
uniprot
Q14AC3
resolver
uniprot_entry
MTR1A_MOUSE
resolver
uniprot_entry
Q14AC3_MOUSE
resolver
amino_acid_sequence
MKGNVSELLNATQQAPGGGEGGRPRPSWLASTLAFILIFTIVVDILGNLLVILSVYRNKKLRNSGNIFVVSLAVADLVVAVYPYPLVLTSILNNGWNLGYLHCQVSAFLMGLSVIGSIFNITGIAMNRYCYICHSLKYDKIYSNKNSLCYVFLIWMLTLIAIMPNLQTGTLQYDPRIYSCTFTQSVSSAYTIAVVVFHFIVPMIIVIFCYLRIWVLVLQVRRRVKPDNKPKLKPQDFRNFVTMFVVFVLFAICWAPLNLIGLIVASDPATMVPRIPEWLFVASYYLAYFNSCLNAIIYGLLNQNFRKEYKKIIVSLCTAKMFFVESSNEEADKIKCKPSPLIPNNNLIKVDSV
uniprot
proteins
function
FUNCTION: High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity (By similarity). Possibly involved in sleep induction, by melatonin activation of the potassium channel KCNMA1/BK and the dissociation of G-beta and G-gamma subunits, thereby decreasing synaptic transmission (PubMed:32958651). {ECO:0000250, ECO:0000269|PubMed:32958651}.
uniprot
proteins
mass_dalton
39837
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
32958651
uniprot
proteins
pubmed
8754776
uniprot
proteins
sequence_length
353
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 33..53; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 67..87; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 106..126; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 146..166; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 191..211; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 244..264; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 278..298; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins