Eml3
entrez
225898
canonical
uniprot
Q8VC03
canonical
ensembl
ENSMUSG00000071647
resolver
ensp
ENSMUSP00000093960
resolver
ensp
ENSMUSP00000153500
resolver
enst
ENSMUST00000096241
resolver
enst
ENSMUST00000224272
resolver
genesymbol
Eml3
resolver
uniprot
A0A286YDN1
resolver
uniprot
Q8R1S1
resolver
uniprot_entry
A0A286YDN1_MOUSE
resolver
uniprot_entry
EMAL3_MOUSE
resolver
uniprot_sec
Q8R1S1
resolver
amino_acid_sequence
MDGAAGPGEGPAHETLQTLSQRLRVQEEEMELVKAALAEALRLLRLHGSTTTLQGSGISAPTRNSSITVPPGLPPTCSPSLVTRGTQTEEELEIVPSSGPPGLSNGPPALQGGSEEPSGTQSEGGCSSSSGAGSPGPPGILRPVQPLQRSDTPRRNSSSSSSPSERPRQKLSRKAASSANLLLRSGSTESRGNKDPLSSPGGPGSRRSNYNLEGISVKMFLRGRPITMYIPSGIRSLEELPSGPPPETLSLDWVYGYRGRDSRSNLFVLRSGEVVYFIACVVVLYRPGGGPGGPGGGGQRHYRGHTDCVRCLAVHPDGVRVASGQTAGVDKDGKPLQPVVHIWDSETLLKLQEIGLGAFERGVGALAFSAADQGAFLCVVDDSNEHMLSVWDCSRGVKLAEIKSTNDSVLAVGFSPRDSSCIVTSGKSHVHFWNWSGGTGAPGNGLLARKQGVFGKYKKPKFIPCFVFLPDGDILTGDSEGNILTWGRSVSDSKTPGRGGAKETYTIVAQAHAHEGSIFALCLRRDGTVLSGGGRDRRLVQWGPGLVALQEAEIPEHFGAVRAIAEGLGSELLVGTTKNALLRGDLAQGFSPVIQGHTDELWGLCTHPSQNRFLTCGHDRQLCLWDGEGHALAWSMDLKETGLCADFHPSGAVVVVGLNTGRWLVLDTETREIVSDVTDGNEQLSVVRYSPDGLYLAIGSHDNMIYIYSVSSCGTKSSRFGRCMGHSSFITHLDWSKDGNFIMSNSGDYEILYWDVAGGCKLLRNRYESRDREWATYTCVLGFHVYGVWPDGSDGTDINSLCRSHNERVVAVADDFCKVHLFQYPCARAKAPSRMYSGHGSHVTSVRFTHDDSYLVSLGGKDASIFQWRVLGAGSSGPAPATPSRTPSLSPASSLDV
uniprot
proteins
function
FUNCTION: Regulates mitotic spindle assembly, microtubule (MT)-kinetochore attachment and chromosome separation via recruitment of HAUS augmin-like complex and TUBG1 to the existing MTs and promoting MT-based MT nucleation (By similarity). Required for proper alignnment of chromosomes during metaphase (By similarity). {ECO:0000250|UniProtKB:Q32P44}.
uniprot
proteins
mass_dalton
95695
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-882 during mitosis is required for interaction with TUBG1, HAUS1, HAUS2, HAUS3, HAUS4, HAUS5, HAUS6, HAUS7 and HAUS8 and their recruitment to spindle microtubules. {ECO:0000250|UniProtKB:Q32P44}.
uniprot
proteins
protein_family
WD repeat EMAP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
897
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}. Cytoplasm {ECO:0000250|UniProtKB:Q32P44}. Nucleus {ECO:0000250|UniProtKB:Q32P44}. Midbody {ECO:0000250|UniProtKB:Q32P44}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q32P44}. Note=Localizes to microtubules throughout all mitotic stages and localizes to the midbody during cytokinesis. {ECO:0000250|UniProtKB:Q32P44}.
uniprot
proteins