GTF2H1
entrez
2965
canonical
uniprot
P32780
canonical
ensembl
ENSG00000110768
resolver
ensembl
ENSG00000288114
resolver
ensp
ENSP00000265963
resolver
ensp
ENSP00000393638
resolver
ensp
ENSP00000621658
resolver
genesymbol
GTF2H1
resolver
genesymbol_syn
BTF2
resolver
hgnc
HGNC:4655
resolver
uniprot
A0A384MTQ8
resolver
uniprot
B3KXE0
resolver
uniprot
D3DQY2
resolver
uniprot
Q6I9Y7
resolver
uniprot
Q9H5K5
resolver
uniprot
Q9NQD9
resolver
uniprot_entry
A0A384MTQ8_HUMAN
resolver
uniprot_entry
TF2H1_HUMAN
resolver
uniprot_sec
B3KXE0
resolver
uniprot_sec
D3DQY2
resolver
uniprot_sec
Q6I9Y7
resolver
uniprot_sec
Q9H5K5
resolver
uniprot_sec
Q9NQD9
resolver
amino_acid_sequence
MATSSEEVLLIVKKVRQKKQDGALYLMAERIAWAPEGKDRFTISHMYADIKCQKISPEGKAKIQLQLVLHAGDTTNFHFSNESTAVKERDAVKDLLQQLLPKFKRKANKELEEKNRMLQEDPVLFQLYKDLVVSQVISAEEFWANRLNVNATDSSSTSNHKQDVGISAAFLADVRPQTDGCNGLRYNLTSDIIESIFRTYPAVKMKYAENVPHNMTEKEFWTRFFQSHYFHRDRLNTGSKDLFAECAKIDEKGLKTMVSLGVKNPLLDLTALEDKPLDEGYGISSVPSASNSKSIKENSNAAIIKRFNHHSAMVLAAGLRKQEAQNEQTSEPSNMDGNSGDADCFQPAVKRAKLQESIEYEDLGKNNSVKTIALNLKKSDRYYHGPTPIQSLQYATSQDIINSFQSIRQEMEAYTPKLTQVLSSSAASSTITALSPGGALMQGGTQQAINQMVPNDIQSELKHLYVAVGELLRHFWSCFPVNTPFLEEKVVKMKSNLERFQVTKLCPFQEKIRRQYLSTNLVSHIEEMLQTAYNKLHTWQSRRLMKKT
uniprot
proteins
function
FUNCTION: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:9852112}.
uniprot
proteins
mass_dalton
62032
uniprot
proteins
post_translational_modification
PTM: (Microbial infection) Upon Rift valley fever virus infection, interacts with NSs leading to ubiquitination by the NSs-FBXO3 E3 ligase and proteasome-dependent degradation. {ECO:0000269|PubMed:39366381}.
uniprot
proteins
protein_family
TFB1 family
uniprot
proteins
pubmed
10024882
uniprot
proteins
pubmed
10882074
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
1529339
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25918396
uniprot
proteins
pubmed
33902107
uniprot
proteins
pubmed
39366381
uniprot
proteins
pubmed
9852112
uniprot
proteins
sequence_length
548
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins