Gabrp
entrez
81658
canonical
uniprot
O09028
canonical
ensembl
ENSRNOG00000032417
resolver
ensembl
ENSRNOG00055002927
resolver
ensembl
ENSRNOG00060003420
resolver
ensp
ENSRNOP00000048081
resolver
ensp
ENSRNOP00055003388
resolver
ensp
ENSRNOP00060004115
resolver
enst
ENSRNOT00000043036
resolver
enst
ENSRNOT00055004573
resolver
enst
ENSRNOT00060005628
resolver
genesymbol
Gabrp
resolver
uniprot_entry
GBRP_RAT
resolver
amino_acid_sequence
MSYSLYLAFVCLNLLAQRMCIQGNQFNVEVSRSDKLSLPGFENLTAGYNKFLRPNFGGDPVRIALTLDIASISSISESNMDYTATIYLRQRWTDPRLVFEGNKSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVTCNMDLSKYPMDTQTCKLQLESWGYDGNDVEFSWLRGNDSVRGLENLRLAQYTIQQYFTLVTVSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLESVPARTCIGVTTVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAVKDRGPAKDSEEVNITNIINSSISSFKRKISFASIEISGDNVNYSDLTMKASDKFKFVFREKIGRIIDYFTIQNPSNVDRYSKLLFPLIFMLANVFYWAYYMYF
uniprot
proteins
function
FUNCTION: Pi subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA) (PubMed:17003036). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:17003036). Pi-containing GABAARs are mostly located in peripheral tissues (PubMed:17003036). In the uterus, pi subunits modulate uterus contraction by altering the sensitivity of GABAARs to pregnanolone (By similarity). In the lungs, pi-containing GABAARs contribute to pulmonary fluid transport via luminal secretion of chloride (PubMed:17003036). {ECO:0000250|UniProtKB:O00591, ECO:0000250|UniProtKB:P47870, ECO:0000269|PubMed:17003036}.
uniprot
proteins
mass_dalton
50481
uniprot
proteins
protein_family
GABRP sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
17003036
uniprot
proteins
pubmed
9182563
uniprot
proteins
sequence_length
440
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:17003036}; Multi-pass membrane protein {ECO:0000255}. Note=Located on the apical plasma membrane of alveolar epithelial type II cells. {ECO:0000269|PubMed:17003036}.
uniprot
proteins
transmembrane_region
TRANSMEM 242..262; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 271..290; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 302..322; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 420..440; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins