Lag3
entrez
297596
canonical
uniprot
Q5BK54
canonical
ensembl
ENSRNOG00000021334
resolver
ensembl
ENSRNOG00055010718
resolver
ensembl
ENSRNOG00060032619
resolver
ensembl
ENSRNOG00065029695
resolver
ensp
ENSRNOP00000036771
resolver
ensp
ENSRNOP00055014563
resolver
ensp
ENSRNOP00060046677
resolver
ensp
ENSRNOP00065042222
resolver
enst
ENSRNOT00000028965
resolver
enst
ENSRNOT00055018122
resolver
enst
ENSRNOT00060056510
resolver
enst
ENSRNOT00065051284
resolver
genesymbol
Lag3
resolver
uniprot_entry
LAG3_RAT
resolver
amino_acid_sequence
MRQDLFLDLLLLQLLWEAPVVSSGPGKELSVVWAQEGAPVHLPCSLEFPHLDPNFLRRGWVTWQHRPDSDQPASIPALDLLQGMPSTRRHPPHRYTVLSVAPGGLRSGRQPLLSHVQLEKRGPQRGDFSLWLRPATRKDAGEYHAFVRLPDRDFSCSLRLRVGQASMIASPPGTLKPSDWVILNCSFSRPDRPVSVHWFQGQSRVPVHNSPRHYLAESFLLLPQVSPLDSGTWGCVLTYRDGFNVSITYNLKVQGLEPVAPLTVYAAEGSRVELPCHLPPVVGTPSLLIAKWTPPGGGPELPVTGKSGNFTLQLENVGRAQAGTYTCSIHLQGRQLSAAVTLAVITVTPKSFGLPGSPQKLLCEVVPASGEGRFVWRPLSDLSRSSLGPVLELQEAKLLAEQWQCQLYEGQKLLGATVYTAESSSGAWSAKRISGDLKGGHLFLSLILGALALFLLVTGAFGFHLWRRQLLRRRFSALEHGIRPPPVQSKIEELEREPETEMEPETEPDPEPQPEPELEPESRQL
uniprot
proteins
function
FUNCTION: Lymphocyte activation gene 3 protein: Inhibitory receptor on antigen activated T-cells. Delivers inhibitory signals upon binding to ligands, such as FGL1. FGL1 constitutes a major ligand of LAG3 and is responsible for LAG3 T-cell inhibitory function. Following TCR engagement, LAG3 associates with TCR-CD3 in the immunological synapse and directly inhibits T-cell activation. May inhibit antigen-specific T-cell activation in synergy with PDCD1/PD-1, possibly by acting as a coreceptor for PDCD1/PD-1. Negatively regulates the proliferation, activation, effector function and homeostasis of both CD8(+) and CD4(+) T-cells. Also mediates immune tolerance: constitutively expressed on a subset of regulatory T-cells (Tregs) and contributes to their suppressive function. Also acts as a negative regulator of plasmacytoid dendritic cell (pDCs) activation. Binds MHC class II (MHC-II); the precise role of MHC-II-binding is however unclear. {ECO:0000250|UniProtKB:Q61790}.; FUNCTION: [Secreted lymphocyte activation gene 3 protein]: May function as a ligand for MHC class II (MHC-II) on antigen-presenting cells (APC), promoting APC activation/maturation and driving Th1 immune response. {ECO:0000250|UniProtKB:Q61790}.
uniprot
proteins
mass_dalton
57988
uniprot
proteins
post_translational_modification
PTM: [Lymphocyte activation gene 3 protein]: Ubiquitinated by CBL and CBLB in response to ligand-binding, initiating a signaling that prevents TCR activation: ubiquitination at Lys-490 via 'Lys-63'-linked ubiquitin chains unleashes the RRFSALE motif from the membrane (By similarity). MHC class II and membrane-bound FGL1 promote ubiquitination by CBL and CBLB; in contrast secreted FGL1 is not able to trigger LAG3 ubiquitination (By similarity). {ECO:0000250|UniProtKB:P18627}.; PTM: [Lymphocyte activation gene 3 protein]: Proteolytically cleaved by ADAM10 and ADAM17 within the connecting peptide region, leading to release of Secreted lymphocyte activation gene 3 protein (sLAG-3). ADAM10 mediates constitutive cleavage, but cleavage increases following T-cell activation, whereas shedding by ADAM17 is induced by TCR signaling in a PRKCQ-dependent manner. {ECO:0000250|UniProtKB:Q61790}.
uniprot
proteins
protein_family
LAG3 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
525
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Lymphocyte activation gene 3 protein]: Cell membrane {ECO:0000250|UniProtKB:Q61790}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Secreted lymphocyte activation gene 3 protein]: Secreted {ECO:0000250|UniProtKB:Q61790}. Note=Produced following cleavage of the main chain. {ECO:0000250|UniProtKB:Q61790}.
uniprot
proteins
transmembrane_region
TRANSMEM 443..463; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins