TRPV5
entrez
56302
canonical
uniprot
Q9NQA5
canonical
ensembl
ENSG00000127412
resolver
ensembl
ENSG00000274348
resolver
ensp
ENSP00000265310
resolver
genesymbol
TRPV5
resolver
genesymbol_syn
ECAC1
resolver
hgnc
HGNC:3145
resolver
uniprot
A0A0A6YY98
resolver
uniprot
A4D2H7
resolver
uniprot
E9PBZ6
resolver
uniprot
Q8N4C1
resolver
uniprot
Q8NDW5
resolver
uniprot
Q8NDX7
resolver
uniprot
Q8NDX8
resolver
uniprot
Q96PM6
resolver
uniprot_entry
TRPV5_HUMAN
resolver
uniprot_sec
A0A0A6YY98
resolver
uniprot_sec
A4D2H7
resolver
uniprot_sec
E9PBZ6
resolver
uniprot_sec
Q8N4C1
resolver
uniprot_sec
Q8NDW5
resolver
uniprot_sec
Q8NDX7
resolver
uniprot_sec
Q8NDX8
resolver
uniprot_sec
Q96PM6
resolver
activity_regulation
ACTIVITY REGULATION: Activated by WNK3. {ECO:0000269|PubMed:18768590}.
uniprot
proteins
amino_acid_sequence
MGGFLPKAEGPGSQLQKLLPSFLVREQDWDQHLDKLHMLQQKRILESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRHSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVVSSDKREARQILEQTPVKELVSFKWNKYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRTHSRDITILQQKLLQEAYETREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTILGGPFHVIIITYASLVLVTMVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPTSLGQFYDYPMALFTTFELFLTVIDAPANYDVDLPFMFSIVNFAFTIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKLPRCLWPRSGICGCEFGLGDRWFLRVENHNDQNPLRVLRYVEVFKNSDKEDDQEHPSEKQPSGAESGTLARASLALPTSSLSRTASQSSSHRGWEILRQNTLGHLNLGLNLSEGDGEEVYHF
uniprot
proteins
function
FUNCTION: Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:11549322, PubMed:18768590). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (PubMed:11549322, PubMed:18768590). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity). {ECO:0000250|UniProtKB:P69744, ECO:0000250|UniProtKB:Q9XSM3, ECO:0000269|PubMed:11549322, ECO:0000269|PubMed:18768590}.
uniprot
proteins
mass_dalton
82562
uniprot
proteins
mutagenesis
MUTAGEN 358; /note="N->Q: Loss of glycosylation."; /evidence="ECO:0000269|PubMed:18768590
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:18768590}.
uniprot
proteins
protein_family
TRPV5 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
protein_family
TrpV subfamily
uniprot
proteins
pubmed
10945469
uniprot
proteins
pubmed
11549322
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18768590
uniprot
proteins
sequence_length
729
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:18768590}; Multi-pass membrane protein {ECO:0000269|PubMed:18768590}. Note=Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells (By similarity). The expression of the glycosylated form in the cell membrane is increased in the presence of WNK3 (PubMed:18768590). {ECO:0000250|UniProtKB:P69744, ECO:0000269|PubMed:18768590}.
uniprot
proteins
transmembrane_region
TRANSMEM 328..348; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9XSM3"; TRANSMEM 386..408; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9XSM3"; TRANSMEM 420..442; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9XSM3"; TRANSMEM 449..469; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9XSM3"; TRANSMEM 493..513; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9XSM3"; TRANSMEM 557..577; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9XSM3
uniprot
proteins