APOL1
entrez
8542
canonical
uniprot
O14791
canonical
ensembl
ENSG00000100342
resolver
ensp
ENSP00000317674
resolver
ensp
ENSP00000380448
resolver
ensp
ENSP00000388477
resolver
ensp
ENSP00000391302
resolver
ensp
ENSP00000392514
resolver
ensp
ENSP00000619600
resolver
enst
ENST00000433768
resolver
genesymbol
APOL1
resolver
genesymbol_syn
APOL
resolver
hgnc
HGNC:618
resolver
uniprot
A5PLQ4
resolver
uniprot
B1AH95
resolver
uniprot
B4DJJ0
resolver
uniprot
B4DU12
resolver
uniprot
E9PF24
resolver
uniprot
O60804
resolver
uniprot
Q2KHQ6
resolver
uniprot
Q5R3P7
resolver
uniprot
Q5R3P8
resolver
uniprot
Q96AB8
resolver
uniprot
Q96PM4
resolver
uniprot
Q9BQ03
resolver
uniprot_entry
APOL1_HUMAN
resolver
uniprot_entry
B1AH95_HUMAN
resolver
uniprot_entry
B4DJJ0_HUMAN
resolver
uniprot_entry
Q2KHQ6_HUMAN
resolver
uniprot_sec
A5PLQ4
resolver
uniprot_sec
B4DU12
resolver
uniprot_sec
E9PF24
resolver
uniprot_sec
O60804
resolver
uniprot_sec
Q5R3P7
resolver
uniprot_sec
Q5R3P8
resolver
uniprot_sec
Q96AB8
resolver
uniprot_sec
Q96PM4
resolver
uniprot_sec
Q9BQ03
resolver
amino_acid_sequence
MEGAALLRVSVLCIWMSALFLGVGVRAEEAGARVQQNVPSGTDTGDPQSKPLGDWAAGTMDPESSIFIEDAIKYFKEKVSTQNLLLLLTDNEAWNGFVAAAELPRNEADELRKALDNLARQMIMKDKNWHDKGQQYRNWFLKEFPRLKSELEDNIRRLRALADGVQKVHKGTTIANVVSGSLSISSGILTLVGMGLAPFTEGGSLVLLEPGMELGITAALTGITSSTMDYGKKWWTQAQAHDLVIKSLDKLKEVREFLGENISNFLSLAGNTYQLTRGIGKDIRALRRARANLQSVPHASASRPRVTEPISAESGEQVERVNEPSILEMSRGVKLTDVAPVSFFLVLDVVYLVYESKHLHEGAKSETAEELKKVAQELEEKLNILNNNYKILQADQEL
uniprot
proteins
disease_involvement
DISEASE: Focal segmental glomerulosclerosis 4 (FSGS4) [MIM:612551]: A renal pathology defined by the presence of segmental sclerosis in glomeruli and resulting in proteinuria, reduced glomerular filtration rate and progressive decline in renal function. Renal insufficiency often progresses to end-stage renal disease, a highly morbid state requiring either dialysis therapy or kidney transplantation. {ECO:0000269|PubMed:20635188, ECO:0000269|PubMed:20647424}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: May play a role in lipid exchange and transport throughout the body. May participate in reverse cholesterol transport from peripheral cells to the liver. A component of trypanosome lytic factor of human serum; plays a crucial role in killing Trypanosoma brucei by forming pores in parasite lysosomal membranes and sensitizing T.brucei to oxidation-stimulated osmotic lysis (PubMed:12621437, PubMed:16020735, PubMed:19997494, PubMed:26645690, PubMed:7723792). {ECO:0000269|PubMed:12621437, ECO:0000269|PubMed:16020735, ECO:0000269|PubMed:19997494, ECO:0000269|PubMed:26645690, ECO:0000269|PubMed:7723792}.
uniprot
proteins
mass_dalton
43974
uniprot
proteins
mutagenesis
MUTAGEN 249; /note="D->K: Results in the loss of trypanolytic activity; when associated with K-253 and K-256."; /evidence="ECO:0000269|PubMed:16020735"; MUTAGEN 253; /note="E->K: Results in the loss of trypanolytic activity; when associated with K-249 and K-256."; /evidence="ECO:0000269|PubMed:16020735"; MUTAGEN 256; /note="E->K: Results in the loss of trypanolytic activity; when associated with K-249 and K-253."; /evidence="ECO:0000269|PubMed:16020735"; MUTAGEN 345; /note="L->Y: Reduces interaction with serum resistance-associated protein from Trypanosoma brucei rhodesiense."; /evidence="ECO:0000269|PubMed:12621437"; MUTAGEN 352; /note="L->A: Reduces interaction with serum resistance-associated protein from Trypanosoma brucei rhodesiense."; /evidence="ECO:0000269|PubMed:12621437"; MUTAGEN 354; /note="Y->L: Reduces interaction with serum resistance-associated protein from Trypanosoma brucei rhodesiense."; /evidence="ECO:0000269|PubMed:12621437"; MUTAGEN 378; /note="L->A: Reduces interaction with serum resistance-associated protein from Trypanosoma brucei rhodesiense and trypanolytic but not pore-forming activity; when associated with A-382 and A-385."; /evidence="ECO:0000269|PubMed:19997494"; MUTAGEN 378; /note="L->P: Reduces interaction with serum resistance-associated protein from Trypanosoma brucei rhodesiense and trypanolytic but not pore-forming activity."; /evidence="ECO:0000269|PubMed:19997494"; MUTAGEN 378; /note="L->S: Reduces interaction with serum resistance-associated protein from Trypanosoma brucei rhodesiense and trypanolytic but not pore-forming activity; when associated with S-382 and S-385."; /evidence="ECO:0000269|PubMed:19997494"; MUTAGEN 382; /note="L->A: Reduces interaction with serum resistance-associated protein from Trypanosoma brucei rhodesiense and trypanolytic but not pore-forming activity; when associated with A-378 and A-385."; /evidence="ECO:0000269|PubMed:19997494"; MUTAGEN 382; /note="L->S: Reduces interaction with serum resistance-associated protein from Trypanosoma brucei rhodesiense and trypanolytic but not pore-forming activity; when associated with S-378 and S-385."; /evidence="ECO:0000269|PubMed:19997494"; MUTAGEN 385; /note="L->A: Reduces interaction with serum resistance-associated protein from Trypanosoma brucei rhodesiense and trypanolytic but not pore-forming activity; when associated with A-378 and A-382."; /evidence="ECO:0000269|PubMed:19997494"; MUTAGEN 385; /note="L->S: Reduces interaction with serum resistance-associated protein from Trypanosoma brucei rhodesiense and trypanolytic but not pore-forming activity; when associated with S-378 and S-382."; /evidence="ECO:0000269|PubMed:19997494"; MUTAGEN 386..389; /note="NNNY->TKIQ: Reduces interaction with serum resistance-associated protein from Trypanosoma brucei rhodesiense. Results in the ability to kill human serum-resistant clones of Trypanosoma brucei rhodesiense."; /evidence="ECO:0000269|PubMed:19997494
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by FAM20C in the extracellular medium. {ECO:0000269|PubMed:26091039}.
uniprot
proteins
protein_family
Apolipoprotein L family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
11290834
uniprot
proteins
pubmed
11374903
uniprot
proteins
pubmed
11944986
uniprot
proteins
pubmed
12621437
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16020735
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
19997494
uniprot
proteins
pubmed
20635188
uniprot
proteins
pubmed
20647424
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26091039
uniprot
proteins
pubmed
26645690
uniprot
proteins
pubmed
7723792
uniprot
proteins
pubmed
9325276
uniprot
proteins
sequence_length
398
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted. Note=Internalized through the endocytic pathway into the lysosomes of Trypanosoma brucei. {ECO:0000269|PubMed:12621437, ECO:0000269|PubMed:16020735}.
uniprot
proteins