SNRPA
entrez
6626
canonical
uniprot
P09012
canonical
ensembl
ENSG00000077312
resolver
ensp
ENSP00000243563
resolver
ensp
ENSP00000595612
resolver
ensp
ENSP00000595613
resolver
ensp
ENSP00000595614
resolver
ensp
ENSP00000595615
resolver
ensp
ENSP00000595619
resolver
enst
ENST00000243563
resolver
enst
ENST00000925553
resolver
enst
ENST00000925554
resolver
enst
ENST00000925555
resolver
enst
ENST00000925556
resolver
enst
ENST00000925560
resolver
genesymbol
SNRPA
resolver
hgnc
HGNC:11151
resolver
uniprot_entry
SNRPA_HUMAN
resolver
amino_acid_sequence
MAVPETRPNHTIYINNLNEKIKKDELKKSLYAIFSQFGQILDILVSRSLKMRGQAFVIFKEVSSATNALRSMQGFPFYDKPMRIQYAKTDSDIIAKMKGTFVERDRKREKRKPKSQETPATKKAVQGGGATPVVGAVQGPVPGMPPMTQAPRIMHHMPGQPPYMPPPGMIPPPGLAPGQIPPGAMPPQQLMPGQMPPAQPLSENPPNHILFLTNLPEETNELMLSMLFNQFPGFKEVRLVPGRHDIAFVEFDNEVQAGAARDALQGFKITQNNAMKISFAKK
uniprot
proteins
function
FUNCTION: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1 snRNP is the first snRNP to interact with pre-mRNA. This interaction is required for the subsequent binding of U2 snRNP and the U4/U6/U5 tri-snRNP. SNRPA binds stem loop II of U1 snRNA. In a snRNP-free form (SF-A) may be involved in coupled pre-mRNA splicing and polyadenylation process. May bind preferentially to the 5'-UGCAC-3' motif on RNAs. {ECO:0000269|PubMed:9848648}.
uniprot
proteins
mass_dalton
31280
uniprot
proteins
mutagenesis
MUTAGEN 11; /note="T->V: Abolishes RNA binding."; /evidence="ECO:0000269|PubMed:1833186"; MUTAGEN 13; /note="Y->F: Substantially reduces RNA binding."; /evidence="ECO:0000269|PubMed:1833186"; MUTAGEN 15; /note="N->V: Abolishes RNA binding."; /evidence="ECO:0000269|PubMed:1833186"; MUTAGEN 16; /note="N->V: Substantially reduces RNA binding."; /evidence="ECO:0000269|PubMed:1833186"; MUTAGEN 52; /note="R->Q: Abolishes RNA binding."; /evidence="ECO:0000269|PubMed:1833186
uniprot
proteins
protein_family
RRM U1 A/B'' family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1826055
uniprot
proteins
pubmed
1831431
uniprot
proteins
pubmed
1833186
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19561594
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2147232
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2962859
uniprot
proteins
pubmed
30538201
uniprot
proteins
pubmed
7984237
uniprot
proteins
pubmed
8070414
uniprot
proteins
pubmed
8602269
uniprot
proteins
pubmed
8609632
uniprot
proteins
pubmed
9265619
uniprot
proteins
pubmed
9312034
uniprot
proteins
pubmed
9848648
uniprot
proteins
sequence_length
282
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins