TAF4
entrez
6874
canonical
uniprot
O00268
canonical
ensembl
ENSG00000130699
resolver
ensp
ENSP00000252996
resolver
enst
ENST00000252996
resolver
genesymbol
TAF4
resolver
genesymbol_syn
TAF2C
resolver
genesymbol_syn
TAF2C1
resolver
genesymbol_syn
TAF4A
resolver
genesymbol_syn
TAFII130
resolver
genesymbol_syn
TAFII135
resolver
hgnc
HGNC:11537
resolver
uniprot
A6NGD9
resolver
uniprot
Q5TBP6
resolver
uniprot
Q99721
resolver
uniprot
Q9BR40
resolver
uniprot
Q9BX42
resolver
uniprot_entry
TAF4_HUMAN
resolver
uniprot_sec
A6NGD9
resolver
uniprot_sec
Q5TBP6
resolver
uniprot_sec
Q99721
resolver
uniprot_sec
Q9BR40
resolver
uniprot_sec
Q9BX42
resolver
amino_acid_sequence
MAAGSDLLDEVFFNSEVDEKVVSDLVGSLESQLAASAAHHHHLAPRTPEVRAAAAGALGNHVVSGSPAGAAGAGPAAPAEGAPGAAPEPPPAGRARPGGGGPQRPGPPSPRRPLVPAGPAPPAAKLRPPPEGSAGSCAPVPAAAAVAAGPEPAPAGPAKPAGPAALAARAGPGPGPGPGPGPGPGPGKPAGPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPAAPGTVIQTPPFVGAAAPPAPAAPSPPAAPAPAAPAAAPPPPPPAPATLARPPGHPAGPPTAAPAVPPPAAAQNGGSAGAAPAPAPAAGGPAGVSGQPGPGAAAAAPAPGVKAESPKRVVQAAPPAAQTLAASGPASTAASMVIGPTMQGALPSPAAVPPPAPGTPTGLPKGAAGAVTQSLSRTPTATTSGIRATLTPTVLAPRLPQPPQNPTNIQNFQLPPGMVLVRSENGQLLMIPQQALAQMQAQAHAQPQTTMAPRPATPTSAPPVQISTVQAPGTPIIARQVTPTTIIKQVSQAQTTVQPSATLQRSPGVQPQLVLGGAAQTASLGTATAVQTGTPQRTVPGATTTSSAATETMENVKKCKNFLSTLIKLASSGKQSTETAANVKELVQNLLDGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLPALRQLTPDSAAFIQQSQQQPPPPTSQATTALTAVVLSSSVQRTAGKTAATVTSALQPPVLSLTQPTQVGVGKQGQPTPLVIQQPPKPGALIRPPQVTLTQTPMVALRQPHNRIMLTTPQQIQLNPLQPVPVVKPAVLPGTKALSAVSAQAAAAQKNKLKEPGGGSFRDDDDINDVASMAGVNLSEESARILATNSELVGTLTRSCKDETFLLQAPLQRRILEIGKKHGITELHPDVVSYVSHATQQRLQNLVEKISETAQQKNFSYKDDDRYEQASDVRAQLKFFEQLDQIEKQRKDEQEREILMRAAKSRSRQEDPEQLRLKQKAKEMQQQELAQMRQRDANLTALAAIGPRKKRKVDCPGPGSGAEGSGPGSVVPGSSGVGTPRQFTRQRITRVNLRDLIFCLENERETSHSLLLYKAFLK
uniprot
proteins
disease_involvement
DISEASE: Intellectual developmental disorder, autosomal dominant 73 (MRD73) [MIM:620450]: An autosomal dominant disorder characterized by intellectual disability ranging from mild to severe, developmental delay, speech delay, behavioral abnormalities, and non-specific dysmorphic facial features. {ECO:0000269|PubMed:33875846, ECO:0000269|PubMed:35904126}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:10594036, PubMed:33795473, PubMed:8942982). TAF4 may maintain an association between the TFIID and TFIIA complexes, while bound to the promoter, together with TBP, during PIC assembly (PubMed:33795473). Potentiates transcriptional activation by the AF-2S of the retinoic acid, vitamin D3 and thyroid hormone (PubMed:9192867). {ECO:0000269|PubMed:10594036, ECO:0000269|PubMed:33795473, ECO:0000269|PubMed:8942982, ECO:0000269|PubMed:9192867}.
uniprot
proteins
mass_dalton
110114
uniprot
proteins
protein_family
TAF4 family
uniprot
proteins
pubmed
10373431
uniprot
proteins
pubmed
10594036
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12601814
uniprot
proteins
pubmed
15735663
uniprot
proteins
pubmed
15960975
uniprot
proteins
pubmed
17483474
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
33795473
uniprot
proteins
pubmed
33875846
uniprot
proteins
pubmed
35904126
uniprot
proteins
pubmed
8647434
uniprot
proteins
pubmed
8942982
uniprot
proteins
pubmed
9192867
uniprot
proteins
sequence_length
1085
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins