Ank3
entrez
361833
canonical
uniprot
O70511
canonical
ensembl
ENSRNOG00000053288
resolver
ensp
ENSRNOP00000071942
resolver
ensp
ENSRNOP00000088491
resolver
ensp
ENSRNOP00000095836
resolver
enst
ENSRNOT00000100191
resolver
genesymbol
Ank3
resolver
uniprot
A0A8I6A9I9
resolver
uniprot
Q574D7
resolver
uniprot
Q574D8
resolver
uniprot
Q574D9
resolver
uniprot
Q574E0
resolver
uniprot
Q574E2
resolver
uniprot
Q8VDA0
resolver
uniprot_entry
A0A8I6A9I9_RAT
resolver
uniprot_entry
ANK3_RAT
resolver
uniprot_sec
Q574D7
resolver
uniprot_sec
Q574D8
resolver
uniprot_sec
Q574D9
resolver
uniprot_sec
Q574E0
resolver
uniprot_sec
Q574E2
resolver
uniprot_sec
Q8VDA0
resolver
amino_acid_sequence
MAHAASQLKKNRDLEINAEEETEKKKKHRKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDVNICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVRFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDTNADIESKMVVNRATESGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIRVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVASLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATSLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLSRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALAIARRLGYISVVDTLKVVTEEIMTTTTITEKHKMNVPETMNEVLDMSDDEVGKASAPEKLSDGEYISDGEEGEDAITGDTDKYLGPQDLKELGDDSLPAEGYVGFSLGARSASLRSFSSDRSYTLNRSSYARDSMMIEELLVPSKEQHLPFTREFDSDSLRHYSWAADTLDNVNLVSSPVHSGFLVSFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQFLGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLSELLNGMDEELDSPEELGTKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIRVGLQAQPVPEETVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKGDTTPSLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLASQLYRELICVPYMAKFVVFAKTNDPVESSLRCFCMTDDRVDKTLEQQENFEEVARSKDIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKVRDTSQEPCGRLSFLKEPKTTKGLPQTAVCNLNITLPAHKKAEKADRRQSFTSLALRKRYSYLTEPSMKTVERSSGTARSLPTTYSHKPFFSTRPYQSWTTTPITVPGPAKSGSLSSSPSNTPSASPLKSIWSVSTPSPIKSTLGASTTSSVKSISDVASPIRSFRTISSPIRTVASPSPYNTQVASGTLGRVPTITEATPIKGVAPNSTLSSRTSPVTTAGSLLEKSSITMTPPASPKANITMYSSSLPFKSIITSAAPLISSPLKSVVSPTKSAADVISTAKAAMASTLSSPLKQMSGHAEVALVNGSVSPLKYPSSSALINGCKATATLQDKISTATNAVSSVVSAAPDTVEKALSTTTAMPFSPLRSYVSAAAPSAFQSLRAPSASALYNSLGPSVGVTTSSVTSSIITVPVYSVGNVLAEPALKKLPDSNSLTKSAAALLSPIKTLTTETRPQPHFNRTSSPVKSSLFLASSALKPSVPSSLSSSQEILKDVAEMKEDLMRMTAILQTDVPEEKPFQTDLPREGRIDDEEPFKIVEKVKEDLVKVSEILKKDVCVESKGPPKSPKSDKGHSPEDDWTEFSSEEIREARQAAASHAPSLPERVHGKANLTRVIDYLTNDIGSSSLTNLKYKFEEAKKEGEERQKRILKPAMALQEHKLKMPPASMRPSTSEKELCKMADSFFGTDAILESPDDFSQHDQDKSPLSDSGFETRSEKTPSAPQSAESTGPKPLFHEVPIPPVITETRTEVVHVIRSYEPSTGEIPQSQPEDPVSPKPPPTFMELEPKPTALSIKEKVKAFQMKASSEEEDHSRVLSKGMRVKEETHITTTTRMVYHSPPGSECASERIEETMSVHDIMKAFQSGRDPSKELAGLFEHKSAMSPDVAKSAAETSAQHAEKDNQMKPKLERIIEVHIEKGPQSPCERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSFADENNVFHDPVDGWQNETPSGSLESPAQARRITGGLLDRLDDSSDQVRDPITSYLTGEAGKFEANGNHAEVIPEAKAKAYFPESQNDIGKQSIKENLKPKTHGCGRAEEPVSPLTAYQKSLEETSKLVIEDAPKPCVPVGMKKMTRTPADGKARLNLQEEEGSARSEPKQGEGYKVKTKKEIRNVEKKAH
uniprot
proteins
function
FUNCTION: Required for the organization of specialized membrane domains by linking the membrane to the cytoskeleton (By similarity). In neurons, participates in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments (By similarity). In skeletal muscle, required for the localization of dystrophin (DMD) and beta-dystroglycan (betaDAG1) to costameres (By similarity). In rod photoreceptors, required for the transport of cyclic nucleotide-gated (CNG) channel subunits from the inner segment to the sensory cilium outer segment, which is critical for phototransduction and outer segment morphogenesis (By similarity). Regulates the activity of the potassium channel KCNA1 in response to dietary Mg(2+) levels, contributing to renal Mg(2+) reabsorption (By similarity). Promotes intracellular adhesion and junctional conductance in myocytes by stabilizing GJA1/CX43 protein abundance and facilitating the localization of PKP2, GJA1/CX43, and SCN5A/Nav1.5 to cell-cell junctions (PubMed:21617128). {ECO:0000250|UniProtKB:G5E8K5, ECO:0000250|UniProtKB:Q12955, ECO:0000269|PubMed:21617128}.
uniprot
proteins
mass_dalton
284443
uniprot
proteins
pubmed
11796721
uniprot
proteins
pubmed
15579534
uniprot
proteins
pubmed
15953600
uniprot
proteins
pubmed
21223964
uniprot
proteins
pubmed
21617128
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
36083912
uniprot
proteins
pubmed
9744885
uniprot
proteins
sequence_length
2622
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q12955}. Cell projection, axon {ECO:0000269|PubMed:9744885}. Cell membrane {ECO:0000269|PubMed:21223964}. Cell membrane, sarcolemma {ECO:0000269|PubMed:15953600, ECO:0000269|PubMed:21223964}. Postsynaptic cell membrane {ECO:0000269|PubMed:11796721}. Lysosome {ECO:0000250|UniProtKB:G5E8K5}. Cell membrane, sarcolemma, T-tubule {ECO:0000269|PubMed:15579534}. Photoreceptor outer segment membrane {ECO:0000250|UniProtKB:G5E8K5}. Cell projection, cilium membrane {ECO:0000250|UniProtKB:G5E8K5}. Note=When transfected in root dorsal ganglia, predominantly located in the axolemma of the axon proximal segments (PubMed:9744885). Also associated with the plasma membrane in neuron cell bodies, although at a lower level than in the axon proximal segment (PubMed:9744885). Localized in rod outer segment membranes (By similarity). Localized to the principle piece of the sperm flagellum and to olfactory cilia (By similarity). Isoform 1 is restricted to the axolemma of the axon proximal segment. Isoforms containing the muscle-specific 76 amino-acid insertion localize to the sarcolemma and on the postsynaptic membrane of neuromuscular junctions (PubMed:11796721). {ECO:0000250|UniProtKB:G5E8K5}.
uniprot
proteins