PcgF3
entrez
69587
canonical
uniprot
Q8BTQ0
canonical
ensembl
ENSMUSG00000033623
resolver
ensp
ENSMUSP00000041790
resolver
ensp
ENSMUSP00000286408
resolver
ensp
ENSMUSP00000286418
resolver
genesymbol
PcgF3
resolver
genesymbol_syn
Rnf3
resolver
genesymbol_syn
Rnf3a
resolver
uniprot
Q8BZT0
resolver
uniprot_entry
PCGF3_MOUSE
resolver
uniprot_sec
Q8BZT0
resolver
amino_acid_sequence
MLTRKIKLWDINAHITCRLCSGYLIDATTVTECLHTFCRSCLVKYLEENNTCPTCRIVIHQSHPLQYIGHDRTMQDIVYKLVPGLQEAEMRKQREFYHKLGMEVPGDIKGEACSAKQHLDPRNGETKADDNSNKETAEEKQEEDNDYHRSDEQVSICLECNSSKLRGLKRKWIRCSAQATVLHLKKFIAKKLNLSSFNELDILCNEEILGKDHTLKFVVVTRWRFKKAPLLLHYRPKMDLL
uniprot
proteins
function
FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:28596365). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (By similarity). Plays a redundant role with PCGF5 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (PubMed:28596365). {ECO:0000250|UniProtKB:Q3KNV8, ECO:0000269|PubMed:28596365}.
uniprot
proteins
mass_dalton
28046
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
28596365
uniprot
proteins
sequence_length
241
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28596365}. Nucleus, nucleoplasm {ECO:0000269|PubMed:28596365}. Note=Recruited by the non-coding RNA Xist to specific nuclear foci that probably correspond to the inactivated X chromosome. {ECO:0000269|PubMed:28596365}.
uniprot
proteins