Shisa6
entrez
380702
canonical
uniprot
Q3UH99
canonical
ensembl
ENSMUSG00000053930
resolver
ensp
ENSMUSP00000071025
resolver
ensp
ENSMUSP00000120862
resolver
genesymbol
Shisa6
resolver
genesymbol_syn
Gm879
resolver
uniprot
A0A172Q417
resolver
uniprot_entry
SHSA6_MOUSE
resolver
uniprot_sec
A0A172Q417
resolver
amino_acid_sequence
MALRRLLLPPLLLSLLLSLASLHLPPGADAARGRSGNRTLNAGAVGGRRAGGALARGGRELNSTARASGVPEAGSRRGQSAAAAAAAAAAASATVTYETCWGYYDVSGQYDKEFECNNSESGYLYCCGTCYYRFCCKKRHEKLDQRQCTNYQSPVWVQTPSTKVVSPGPENKYDPEKDKTNFTVYITCGVIAFVIVAGVFAKVSYDKAHRPPREMNIHRALADILRQQGPIPIAHCERETISAIDTSPKENTPVRSTSKNHYTPVRTAKQTPGDRQYNHPILSSATQTPTHEKPRMNNILTSATEPYDLSFSRSYQNLAHLPPSYESAVKTNPSKYSSLKRLTDKEADEYYMRRRHLPDLAARGTLPLNVIQMSQQKPLPRERPRRPIRAMSQDRVLSPRRGLPDEFGMPYDRILSDEQLLSTERLHSQDPLLSPERTAFPEQSLSRAISHTDVFVSTPVLDRYRMTKMHSHPSASNNSYATLGQSQTAAKRHAFASRRHNTVEQLHYIPGHHTCYTASKTEVTV
uniprot
proteins
function
FUNCTION: Involved in maintenance of high-frequency synaptic transmission at hippocampal CA3-CA1 synapses. Regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (PubMed:26931375). May play a role in self-renewal and differentiation of spermatogonial stem cells by inhibiting canonical Wnt signaling pathway (PubMed:28196692). {ECO:0000269|PubMed:26931375, ECO:0000269|PubMed:28196692}.
uniprot
proteins
mass_dalton
58426
uniprot
proteins
mutagenesis
MUTAGEN 522..525; /note="Missing: Loss of interaction with PDZ-domain of DLG4."; /evidence="ECO:0000269|PubMed:26931375
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:26931375}.
uniprot
proteins
protein_family
Shisa family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26623514
uniprot
proteins
pubmed
26931375
uniprot
proteins
pubmed
28196692
uniprot
proteins
pubmed
29199957
uniprot
proteins
sequence_length
525
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic density membrane {ECO:0000269|PubMed:26931375}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 181..201; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins