TMEM181
entrez
57583
canonical
uniprot
Q9P2C4
canonical
ensembl
ENSG00000146433
resolver
ensp
ENSP00000356057
resolver
ensp
ENSP00000507085
resolver
ensp
ENSP00000519409
resolver
ensp
ENSP00000519410
resolver
ensp
ENSP00000519507
resolver
ensp
ENSP00000662647
resolver
ensp
ENSP00000707006
resolver
ensp
ENSP00000707007
resolver
enst
ENST00000714226
resolver
genesymbol
TMEM181
resolver
genesymbol_syn
GPR178
resolver
genesymbol_syn
KIAA1423
resolver
hgnc
HGNC:20958
resolver
uniprot
A0A804HII6
resolver
uniprot
A0AAQ5BHM7
resolver
uniprot
Q5VTU1
resolver
uniprot_entry
A0AAQ5BHM7_HUMAN
resolver
uniprot_entry
TM181_HUMAN
resolver
uniprot_sec
A0A804HII6
resolver
uniprot_sec
Q5VTU1
resolver
amino_acid_sequence
MEPLAPMRLYTLSKRHFVLVFVVFFICFGLTIFVGIRGPKVIQTSAANFSLNNSKKLKPIQILSNPLSTYNQQLWLTCVVELDQSKETSIKTSFPMTVKVDGVAQDGTTMYIHNKVHNRTRTLTCAGKCAEIIVAHLGYLNYTQYTVIVGFEHLKLPIKGMNFTWKTYNPAFSRLEIWFRFFFVVLTFIVTCLFAHSLRKFSMRDWGIEQKWMSVLLPLLLLYNDPFFPLSFLVNSWLPGMLDDLFQSMFLCALLLFWLCVYHGIRVQGERKCLTFYLPKFFIVGLLWLASVTLGIWQTVNELHDPMYQYRVDTGNFQGMKVFFMVVAAVYILYLLFLIVRACSELRHMPYVDLRLKFLTALTFVVLVISIAILYLRFGAQVLQDNFVAELSTHYQNSAEFLSFYGLLNFYLYTLAFVYSPSKNALYESQLKDNPAFSMLNDSDDDVIYGSDYEEMPLQNGQAIRAKYKEESDSD
uniprot
proteins
function
FUNCTION: Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication. {ECO:0000269|PubMed:19965467}.
uniprot
proteins
mass_dalton
55015
uniprot
proteins
protein_family
TMEM181 family
uniprot
proteins
pubmed
10718198
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19965467
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
sequence_length
475
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 16..36; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 131..151; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 175..195; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 214..234; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 245..265; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 276..296; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 320..340; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 356..376; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 401..421; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins