Alyref2
entrez
56009
canonical
uniprot
Q9JJW6
canonical
ensembl
ENSMUSG00000060244
resolver
ensp
ENSMUSP00000080242
resolver
enst
ENSMUST00000081527
resolver
genesymbol
Alyref2
resolver
genesymbol_syn
Ref2
resolver
genesymbol_syn
Refbp2
resolver
uniprot
G3X9I4
resolver
uniprot
Q8C869
resolver
uniprot_entry
ALRF2_MOUSE
resolver
uniprot_entry
G3X9I4_MOUSE
resolver
uniprot_sec
Q8C869
resolver
amino_acid_sequence
MADKMDMSLDDIIKLNRNQRRVNRGGGPRRNRPAIARGGRNRPAPYSRPKPLPDKWQHDLFDSGCGGGEGVETGAKLLVSNLDFGVSDADIQELFAEFGTLKKAAVDYDRSGRSLGTADVHFERRADALKAMKQYKGVPLDGRPMDIQLVASQIDPQRRPAQSGNRGGMTRSRGSGGFGGRGSQGRGRGTGRNSKQQQLSAEELDAQLDAYNARMDTS
uniprot
proteins
function
FUNCTION: Export adapter involved in spliced and unspliced mRNA nuclear export. Binds mRNA which is transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway); enhances NXF1-NXT1 RNA-binding activity. {ECO:0000269|PubMed:10786854, ECO:0000269|PubMed:11158589, ECO:0000269|PubMed:18364396}.
uniprot
proteins
mass_dalton
23730
uniprot
proteins
mutagenesis
MUTAGEN 24; /note="R->E: Impairs interaction with NXF1."; /evidence="ECO:0000269|PubMed:18364396"; MUTAGEN 29; /note="R->E: Abolishes interaction with NXF1; when associated with E-30."; /evidence="ECO:0000269|PubMed:18364396"; MUTAGEN 30; /note="R->E: Abolishes interaction with NXF1; when associated with E-29."; /evidence="ECO:0000269|PubMed:18364396"; MUTAGEN 32; /note="R->E: Impairs interaction with NXF1."; /evidence="ECO:0000269|PubMed:18364396
uniprot
proteins
post_translational_modification
PTM: Arginine methylation reduces RNA binding and enhances mRNA transfer to the NXF1-NXT1 heterodimer for nuclear export. {ECO:0000269|PubMed:20129943}.
uniprot
proteins
pubmed
10786854
uniprot
proteins
pubmed
11158589
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17000901
uniprot
proteins
pubmed
18364396
uniprot
proteins
pubmed
20129943
uniprot
proteins
pubmed
21253573
uniprot
proteins
pubmed
24550725
uniprot
proteins
sequence_length
218
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q86V81}. Cytoplasm {ECO:0000250|UniProtKB:Q86V81}.
uniprot
proteins