Mybbp1a
entrez
18432
canonical
uniprot
Q7TPV4
canonical
ensembl
ENSMUSG00000040463
resolver
ensp
ENSMUSP00000044827
resolver
enst
ENSMUST00000045633
resolver
genesymbol
Mybbp1a
resolver
genesymbol_syn
P160
resolver
uniprot
O35851
resolver
uniprot
Q3U2W2
resolver
uniprot
Q80Y66
resolver
uniprot
Q8R4X2
resolver
uniprot
Q99KP0
resolver
uniprot_entry
MBB1A_MOUSE
resolver
uniprot_entry
Q3U2W2_MOUSE
resolver
uniprot_sec
O35851
resolver
uniprot_sec
Q80Y66
resolver
uniprot_sec
Q8R4X2
resolver
uniprot_sec
Q99KP0
resolver
amino_acid_sequence
MAEMKSPTKAEPATPAEAAQSDRHSLLEHSREFLDFFWDIAKPDQETRLRATEKLLEYLRTRPNDSEMKYALKRLITGLGVGREAARPCYSLALAQLLQSFEDIPLCDILDQIQEKYSLQAMNKAMMRPSLFANLFGVLALFQSGRLVKDKEALMKSVQLLKILSQHPNHLQGQPIKALVDILSEVPESMFQEILPKVLKGNMKVILRSPKYLELFLLAKQRVPTKLESLMGSVDLFSEDNIPSLVNILKVAANSVKKEHKLPNVALDLLRLALKESRFELFWKKVLEEGLLKNPSWTSSYMCFRLLGASLPLLSEEQLQLVMRGDLIRHFGENMVISKPQNLFKIIPEISTYVGTFLEGCQDDPKRQLTMMVAFTTITNQGLPVMPTFWRVTRFLNAEALQSYVAWLRDMFLQPDLNSLVDFSTANQKRAQDASLNVPERAVFRLRKWIIHRLVSLVDHLHLEKDEAVVEQIARFCLFHAFFKTKKATPQIPETKQHFSFPLDDRNRGVFVSAFFSLLQTLSVKFRQTPDLAENGKPWTYRLVQLADMLLNHNRNVTSVTSLTTQQRQAWDQMMSTLKELEARSSETRAIAFQHLLLLVGLHIFKSPAESCDVLGDIQTCIKKSMEQNPRRSRSRAKASQEPVWVEVMVEILLSLLAQPSNLMRQVVRSVFGHICPHLTPRCLQLILAVLSPVTNEDEDDNVVVTDDADEKQLQHGEDEDSDNEDNKNSESDMDSEDGEESEEEDRDKDVDPGFRQQLMEVLKAGNALGGVDNEEEEELGDEAMMALDQNLASLFKEQKMRIQARNEEKNKLQKEKKLRRDFQIRALDLIEVLVTKQPEHPLILELLEPLLNVIQHSMRSKGSTKQEQDLLHKTARIFMHHLCRARRYCHEVGPCAEALHAQVERLVQQAGSQADASVALYYFNASLYLLRVLKGNTNKRHQDGHKLHGADTEDSEDQAANCLDLDFVTRVYSASLESLLTKRNSSLTVPMFLSLFSRYPVICKNLLPVLAQHVAGPSRPRHQAQACLMLQKTLSARELRVCFEDPEWEQLITQLLGKATQTLQTLGEAQSKGEHQKELSILELLNTLLRTVNHEKLSVDLTAPLGVLQSKQQKLQQSLQQGNHSSGSNRLYDLYWQAMRMLGVQRPKSEKKNAKDIPSDTQSPVSTKRKKKGFLPETKKRKKLKSEGTTPEKNAASQQDAVTEGAMPAATGKDQPPSTGKKKRKRVKASTPSQVNGITGAKSPAPSNPTLSPSTPAKTPKLQKKKEKLSQVNGATPVSPIEPESKKHHQEALSTKEVIRKSPHPQSALPKKRARLSLVSRSPSLLQSGVKKRRVASRRVQTP
uniprot
proteins
function
FUNCTION: May activate or repress transcription via interactions with sequence specific DNA-binding proteins (PubMed:11956195, PubMed:14744933, PubMed:9447996). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (PubMed:14744933). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (PubMed:19129230). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (PubMed:19129230). Has a role in rRNA biogenesis together with PWP1 (By similarity). {ECO:0000250|UniProtKB:Q9BQG0, ECO:0000269|PubMed:11956195, ECO:0000269|PubMed:14744933, ECO:0000269|PubMed:19129230, ECO:0000269|PubMed:9447996}.
uniprot
proteins
mass_dalton
152037
uniprot
proteins
mutagenesis
MUTAGEN 249; /note="L->A: Reduced nuclear export; when associated with A-251."; /evidence="ECO:0000269|PubMed:12941609"; MUTAGEN 251; /note="V->A: Reduced nuclear export; when associated with A-249."; /evidence="ECO:0000269|PubMed:12941609"; MUTAGEN 272; /note="L->A: Reduced nuclear export; when associated with A-274."; /evidence="ECO:0000269|PubMed:12941609"; MUTAGEN 274; /note="L->A: Reduced nuclear export; when associated with A-272."; /evidence="ECO:0000269|PubMed:12941609
uniprot
proteins
post_translational_modification
PTM: Citrullinated by PADI4. {ECO:0000269|PubMed:24463520}.
uniprot
proteins
protein_family
MYBBP1A family
uniprot
proteins
pubmed
11956195
uniprot
proteins
pubmed
12941609
uniprot
proteins
pubmed
14744933
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19129230
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24463520
uniprot
proteins
pubmed
9447996
uniprot
proteins
sequence_length
1344
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12941609}. Nucleus, nucleolus {ECO:0000269|PubMed:12941609, ECO:0000269|PubMed:19129230}. Cytoplasm {ECO:0000269|PubMed:12941609}. Note=Predominantly nucleolar. Also shuttles between the nucleus and cytoplasm. Nuclear import may be mediated by KPNA2, while export appears to depend partially on XPO1/CRM1. {ECO:0000269|PubMed:12941609}.
uniprot
proteins