Cyb561a3
entrez
361729
canonical
uniprot
Q5U2W7
canonical
ensembl
ENSRNOG00000020702
resolver
ensembl
ENSRNOG00055018128
resolver
ensembl
ENSRNOG00060024068
resolver
ensembl
ENSRNOG00065025268
resolver
ensp
ENSRNOP00000028094
resolver
ensp
ENSRNOP00000078502
resolver
ensp
ENSRNOP00055024706
resolver
ensp
ENSRNOP00060034613
resolver
ensp
ENSRNOP00065035763
resolver
enst
ENSRNOT00000028094
resolver
enst
ENSRNOT00000113027
resolver
enst
ENSRNOT00055030715
resolver
enst
ENSRNOT00060041753
resolver
enst
ENSRNOT00065043575
resolver
genesymbol
Cyb561a3
resolver
genesymbol_syn
Cybasc3
resolver
uniprot
A0A8I5ZL22
resolver
uniprot
A0A8L2QF34
resolver
uniprot_entry
A0A8I5ZL22_RAT
resolver
uniprot_entry
A0A8L2QF34_RAT
resolver
uniprot_entry
CYAC3_RAT
resolver
amino_acid_sequence
MASGWFYMSCMVLGSLGSMCILFTTYWMQYWRGGFAWDGTVLMFNWHPVLMVSGMVVLYGAASLVYRLPASWVGPKLPWKVLHAALHLLAFTVTVVGLTAVFGFHNHSKITHLYSLHSWLGITTVALFACQWFLGFAVFLLPWASQWLRSLLKPVHVFFGACILSLSIASVISGINEKLFFVLKNATRPYSSLPGEAVFANSTGILVVSFGLLVLYILLASSWRRPDPGALTDRQVWLLVSHYRWDKAKKACFAPC
uniprot
proteins
ec_number
7.2.1.3
uniprot
proteins
function
FUNCTION: Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce iron cations Fe(3+) into Fe(2+) in the lumen of the late endosome and lysosome. Reduced iron can then be extruded from the late endosome and lysosome to the cytoplasm by divalent metal-specific transporters. It is therefore most probably involved in endosomal and lysosomal cellular iron homeostasis. {ECO:0000250|UniProtKB:Q6P1H1}.
uniprot
proteins
mass_dalton
28650
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q6P1H1}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
256
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250|UniProtKB:Q6P1H1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q53TN4}. Lysosome membrane {ECO:0000250|UniProtKB:Q6P1H1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q53TN4}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 41..61; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 84..104; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 120..140; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 155..175; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 203..223; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins