CHIA
entrez
27159
canonical
uniprot
Q9BZP6
canonical
ensembl
ENSG00000134216
resolver
ensp
ENSP00000338970
resolver
ensp
ENSP00000358755
resolver
ensp
ENSP00000387671
resolver
ensp
ENSP00000390476
resolver
ensp
ENSP00000391132
resolver
ensp
ENSP00000436946
resolver
genesymbol
CHIA
resolver
hgnc
HGNC:17432
resolver
uniprot
A8K3T7
resolver
uniprot
Q1M0P3
resolver
uniprot
Q1M0P4
resolver
uniprot
Q2VT96
resolver
uniprot
Q32W79
resolver
uniprot
Q32W80
resolver
uniprot
Q3B866
resolver
uniprot
Q5U5Z5
resolver
uniprot
Q5VUV4
resolver
uniprot
Q86UD8
resolver
uniprot
Q9ULY3
resolver
uniprot
Q9ULY4
resolver
uniprot_entry
A8K3T7_HUMAN
resolver
uniprot_entry
CHIA_HUMAN
resolver
uniprot_entry
Q1M0P3_HUMAN
resolver
uniprot_entry
Q1M0P4_HUMAN
resolver
uniprot_entry
Q2VT96_HUMAN
resolver
uniprot_sec
Q32W79
resolver
uniprot_sec
Q32W80
resolver
uniprot_sec
Q3B866
resolver
uniprot_sec
Q5U5Z5
resolver
uniprot_sec
Q5VUV4
resolver
uniprot_sec
Q86UD8
resolver
uniprot_sec
Q9ULY3
resolver
uniprot_sec
Q9ULY4
resolver
amino_acid_sequence
MTKLILLTGLVLILNLQLGSAYQLTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAGRQNNEITTIEWNDVTLYQAFNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFITSVIKFLRQYEFDGLDFDWEYPGSRGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMVTAAVAAGISNIQSGYEIPQLSQYLDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAYLNVDYVMNYWKDNGAPAEKLIVGFPTYGHNFILSNPSNTGIGAPTSGAGPAGPYAKESGIWAYYEICTFLKNGATQGWDAPQEVPYAYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVWAIDLDDFTGTFCNQGKFPLISTLKKALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSSGGSSGGSGFCAVRANGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNWA
uniprot
proteins
ec_number
3.2.1.14
uniprot
proteins
function
FUNCTION: Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding. {ECO:0000269|PubMed:11085997, ECO:0000269|PubMed:18824549, ECO:0000269|PubMed:19342690, ECO:0000269|PubMed:19435888}.
uniprot
proteins
mass_dalton
52271
uniprot
proteins
mutagenesis
MUTAGEN 138; /note="D->A: Loss of chitinase activity. No effect on protection against apoptosis or on AKT1 activation."; /evidence="ECO:0000269|PubMed:19342690
uniprot
proteins
protein_family
Chitinase class II subfamily
uniprot
proteins
protein_family
Glycosyl hydrolase 18 family
uniprot
proteins
pubmed
10548734
uniprot
proteins
pubmed
11085997
uniprot
proteins
pubmed
15192232
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18824549
uniprot
proteins
pubmed
19241384
uniprot
proteins
pubmed
19342690
uniprot
proteins
pubmed
19435888
uniprot
proteins
sequence_length
476
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Secreted. Note=Secretion depends on EGFR activity.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm.
uniprot
proteins