Adh7
entrez
11529
canonical
uniprot
Q64437
canonical
ensembl
ENSMUSG00000055301
resolver
ensp
ENSMUSP00000087633
resolver
enst
ENSMUST00000090171
resolver
genesymbol
Adh7
resolver
genesymbol_syn
Adh-3
resolver
genesymbol_syn
Adh3
resolver
genesymbol_syn
Adh4
resolver
uniprot
Q9D748
resolver
uniprot_entry
ADH7_MOUSE
resolver
uniprot_entry
Q9D748_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Retinol oxidation is inhibited by the detergent Tween 80. Ethanol inhibits both all-trans-retinol and 9-cis-retinol oxidation. 13-cis-retinol is an effective competitive inhibitor of the 9-cis-retinol oxidation. All-trans-retinoic acid is a powerful inhibitor of all-trans-retinol oxidation. 13-cis-retinoic acid is a powerful inhibitor of all-trans-retinol oxidation. Cimetidine competitively inhibited ethanol oxidation. {ECO:0000250|UniProtKB:P40394}.
uniprot
proteins
amino_acid_sequence
MGTAGKVIKCKAAVLWGVNQPFSIEEIEVAPPKAKEVRVKILATGICRTDDHIIKGSMVSKFPVIVGHEAVGVVESVGEGVTTVRPGDKVIPLFLPQCRECNACLNPEGNLCIRSDLTGRGVLADGTTRFTCKGKPVQHFMNTSTFTEYTVLDESSVAKVDGAAPPEKACLIGCGFSTGYGAAVKTAKVTPGSTCVVFGLGGVGLSVIMGCKAAGASRIIGIDINKDKFQKALAVGATECISPKDSTKPISEVLSDMTGNTIQYTFEVIGRLETMVDALSSCHMNYGTSVVVGAPPSAKMLTYDPMLLFTGRTWKGCVFGGWKSRDDVPKLVTEFLEKKFDLDQLITHTLPFNNINEGFELLYSGKSIRTVLTF
uniprot
proteins
ec_number
1.1.1.1
uniprot
proteins
ec_number
1.1.1.105
uniprot
proteins
ec_number
1.1.1.66
uniprot
proteins
function
FUNCTION: Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, aldehyde and omega-hydroxy fatty acids and their derivatives. Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid. In vitro can also catalyze the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives. Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal. Catalyzes in the oxidative direction with higher efficiency. Therefore may participate in retinoid metabolism, fatty acid omega-oxidation, and elimination of cytotoxic aldehydes produced by lipid peroxidation. {ECO:0000250|UniProtKB:P40394}.
uniprot
proteins
mass_dalton
39904
uniprot
proteins
protein_family
Class-IV subfamily
uniprot
proteins
protein_family
Zinc-containing alcohol dehydrogenase family
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
7738026
uniprot
proteins
pubmed
9126489
uniprot
proteins
sequence_length
374
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins