Lmx1a
entrez
110648
canonical
uniprot
Q9JKU8
canonical
ensembl
ENSMUSG00000026686
resolver
ensp
ENSMUSP00000028003
resolver
ensp
ENSMUSP00000107008
resolver
enst
ENSMUST00000028003
resolver
enst
ENSMUST00000111377
resolver
genesymbol
Lmx1a
resolver
uniprot
Q543W2
resolver
uniprot_entry
LMX1A_MOUSE
resolver
uniprot_entry
Q543W2_MOUSE
resolver
amino_acid_sequence
MLDGLKMEENFQSAIETSASFSSLLGRAVSPKSVCEGCQRVISDRFLLRLNDSFWHEQCVQCASCKEPLETTCFYRDKKLYCKYHYEKLFAVKCGGCFEAIAPNEFVMRAQKSVYHLSCFCCCVCERQLQKGDEFVLKEGQLLCKGDYEKERELLSLVSPAASDSGKSDDEESLCKSAHGAGKGASEDGKDHKRPKRPRTILTTQQRRAFKASFEVSSKPCRKVRETLAAETGLSVRVVQVWFQNQRAKMKKLARRQQQQQQDQQNTQRLTSAQTNGSGNAGMEGIMNPYTTLPTPQQLLAIEQSVYNSDPFRQGLTPPQMPGDHMHPYGAEPLFHDLDSDDTSLSNLGDCFLATSEAGPLQSRVGNPIDHLYSMQNSYFTS
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Lmx1a are the cause of the spontaneous neurologic mutant mouse, called 'dreher' (dr) and results from a failure of the roof plate to develop.
uniprot
proteins
function
FUNCTION: Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae.
uniprot
proteins
mass_dalton
42857
uniprot
proteins
pubmed
10693804
uniprot
proteins
sequence_length
382
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
uniprot
proteins