Slc4a9
entrez
266612
canonical
uniprot
Q8K4V2
canonical
ensembl
ENSRNOG00000018525
resolver
ensp
ENSRNOP00000025137
resolver
enst
ENSRNOT00000025137
resolver
genesymbol
Slc4a9
resolver
genesymbol_syn
Ae4
resolver
uniprot
F1LR96
resolver
uniprot_entry
B3A4_RAT
resolver
uniprot_entry
F1LR96_RAT
resolver
activity_regulation
ACTIVITY REGULATION: 4,4'-diisothiocyanatodihydrostilbene-2,2'- disulfonic acid (H2DIDS) potently inhibits chloride/hydrogencarbonate antiporter activity with 50% inhibition at about 5 uM (PubMed:12225984). Completely inhibits chloride/hydrogencarbonate antiporter activity at 200 uM of 4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid (DIDS) (PubMed:12225984). {ECO:0000269|PubMed:12225984}.
uniprot
proteins
amino_acid_sequence
MKLPGQEDFEGSDAHENVCSEQLDGDLGPGSGLDGPSDIDNGKAQGCKDPLLFIQLNELLGWPQALEWRETGRWLLFEEKLDIGAGRWSAPHVPTLALPSLQKLRGLLAEGIVLLDCPARSLLELVEQVVRVESLSPELRGQLQALLLQRPQHHIQTTGIRPCRRSNAFRKASRDEDTLLKHQNPLRQKLPPGAEAAAVLAGELGFLEQPLAAFVRLQNPVVLEPLTEVVLPSRFFCLLLGPSTLGRSYHETGRAAAVLLSDPQFQWSVRRASNLHDLLAALDAFLQEVTALPPGRWDRTARIPPPKCLPSQHKRFPSKLQEVTSLSRQSAALAENKHHHGPHTPIPELQRTGRLFGGLVQDVRRKACWYPSDFLDALHPQCFSAVLYIYLATVTNAITFGGLLGDATEGAQGVLESFLGTAVAGATFCLMAGQPLTILSSTGPVLVFERLLFSFSRDYSLDYLPFRLWVGIWVATFCLALVATEASLLVRYFTRFTEEGFCALISLIFIYDAVGKMLNLIRAYPIQRPGSPAYSCFCQYPGTGGNASEFDSTMFKDTEDVLNVHPGLVNASFLPPSECIRQGGYPRGPSCHTVPDIAFFSLLLFFTSFLCAIALKHVKNSRLFPSVVRKVFSDFSSVLAILLGCGLDAFLGLATPKLLVPTEFKPTLPGRGWLVSPFGANPWWLSVAAALPALLLSILIFMDQQITAVILNRAEYRLQKGAGFHLDLFCVAVLMLFTSALGLPWYVSATVISLAHMDSLRRESKACVPGEDPNFLGIREQRLTGLVVFILTGVSIFLAPVLKFIPMPVLYGIFLYMGVAALSSMQFMKRVQLLLMPRKHQPDVLLLRHVPLIRVHLFTAIQLACLGLLWVIKSTPAAIVFPLMLLGLVAVRKALEWIFSPQELLWLDELMPEEEKTIPENRPEPEHLFSGNDSENSELMYQPKAPEINISVN
uniprot
proteins
function
FUNCTION: Electroneutral Cl(-)/HCO3(-) antiporter that favors chloride ion entry and efflux of hydrogencarbonate and sodium ion across the basolateral membrane and may participate in salivary secretion (PubMed:12225984). Also mediates Cl(-)/HCO3(-) exchange activity in the presence of K(+) as well as Cs(+), Li(+), and Rb(+). Does not contribute to Cl(-)/HCO3(-) exchanger in the apical membrane of the upper villous epithelium (By similarity). {ECO:0000250|UniProtKB:A0A494BA31, ECO:0000269|PubMed:12225984}.
uniprot
proteins
mass_dalton
105320
uniprot
proteins
protein_family
Anion exchanger (TC 2.A.31) family
uniprot
proteins
pubmed
12225984
uniprot
proteins
sequence_length
953
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:12225984}; Multi-pass membrane protein {ECO:0000255}. Note=Localized in the basolateral membrane of both alpha-intercalated cells and beta-intercalated cells in the cortical collecting duct (CCD) kidney cells (PubMed:12225984). Localized in the basolateral membrane of the submandibular gland (SMG) duct (By similarity). {ECO:0000250|UniProtKB:A0A494BA31, ECO:0000269|PubMed:12225984}.
uniprot
proteins
transmembrane_region
TRANSMEM 385..405; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 413..433; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 470..490; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 501..521; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 594..614; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 635..655; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 682..702; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 728..748; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 785..805; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 807..827; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 869..889; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins