TLE5
entrez
166
canonical
uniprot
Q08117
canonical
ensembl
ENSG00000104964
resolver
ensp
ENSP00000221561
resolver
ensp
ENSP00000317537
resolver
ensp
ENSP00000551152
resolver
genesymbol
TLE5
resolver
genesymbol_syn
AES
resolver
genesymbol_syn
GRG
resolver
genesymbol_syn
GRG5
resolver
hgnc
HGNC:307
resolver
uniprot
B2RBL0
resolver
uniprot
Q12808
resolver
uniprot
Q14CJ1
resolver
uniprot
Q96TG9
resolver
uniprot
Q9UDY9
resolver
uniprot_entry
TLE5_HUMAN
resolver
uniprot_sec
B2RBL0
resolver
uniprot_sec
Q12808
resolver
uniprot_sec
Q14CJ1
resolver
uniprot_sec
Q96TG9
resolver
uniprot_sec
Q9UDY9
resolver
amino_acid_sequence
MMFPQSRHSGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALALPLTPLPVGLQPPSLPAVSAGTGLLSLSALGSQAHLSKEDKNGHDGDTHQEDDGEKSD
uniprot
proteins
function
FUNCTION: Transcriptional corepressor. Acts as a dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development. {ECO:0000269|PubMed:10660609, ECO:0000269|PubMed:10748198}.
uniprot
proteins
mass_dalton
21970
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by XIAP/BIRC4. {ECO:0000269|PubMed:22304967}.
uniprot
proteins
protein_family
WD repeat Groucho/TLE family
uniprot
proteins
pubmed
10660609
uniprot
proteins
pubmed
10748198
uniprot
proteins
pubmed
11390640
uniprot
proteins
pubmed
12441302
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
22304967
uniprot
proteins
pubmed
8365415
uniprot
proteins
pubmed
9809752
uniprot
proteins
sequence_length
197
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins