EIF4G3
entrez
8672
canonical
uniprot
O43432
canonical
ensembl
ENSG00000075151
resolver
ensp
ENSP00000264211
resolver
ensp
ENSP00000364071
resolver
ensp
ENSP00000383274
resolver
ensp
ENSP00000473510
resolver
ensp
ENSP00000489051
resolver
ensp
ENSP00000507662
resolver
ensp
ENSP00000507819
resolver
ensp
ENSP00000509442
resolver
ensp
ENSP00000509547
resolver
ensp
ENSP00000509941
resolver
enst
ENST00000400422
resolver
enst
ENST00000602326
resolver
enst
ENST00000684485
resolver
enst
ENST00000688741
resolver
genesymbol
EIF4G3
resolver
hgnc
HGNC:3298
resolver
uniprot
A0A0A0MSA7
resolver
uniprot
A0A804HJV5
resolver
uniprot
A0A8I5QJH9
resolver
uniprot
A0A8J9G7U8
resolver
uniprot
B4DXR2
resolver
uniprot
B9EGQ7
resolver
uniprot
Q15597
resolver
uniprot
Q504Z1
resolver
uniprot
Q59GJ0
resolver
uniprot
Q5SWC3
resolver
uniprot
Q8NEN1
resolver
uniprot_entry
A0A0A0MSA7_HUMAN
resolver
uniprot_entry
A0A804HJV5_HUMAN
resolver
uniprot_entry
A0A8I5QJH9_HUMAN
resolver
uniprot_entry
A0A8J9G7U8_HUMAN
resolver
uniprot_entry
B4DXR2_HUMAN
resolver
uniprot_entry
IF4G3_HUMAN
resolver
uniprot_entry
Q59GJ0_HUMAN
resolver
uniprot_sec
B9EGQ7
resolver
uniprot_sec
Q15597
resolver
uniprot_sec
Q504Z1
resolver
uniprot_sec
Q5SWC3
resolver
uniprot_sec
Q8NEN1
resolver
amino_acid_sequence
MNSQPQTRSPFFQRPQIQPPRATIPNSSPSIRPGAQTPTAVYQANQHIMMVNHLPMPYPVPQGPQYCIPQYRHSGPPYVGPPQQYPVQPPGPGPFYPGPGPGDFPNAYGTPFYPSQPVYQSAPIIVPTQQQPPPAKREKKTIRIRDPNQGGKDITEEIMSGGGSRNPTPPIGRPTSTPTPPQQLPSQVPEHSPVVYGTVESAHLAASTPVTAASDQKQEEKPKPDPVLKSPSPVLRLVLSGEKKEQEGQTSETTAIVSIAELPLPPSPTTVSSVARSTIAAPTSSALSSQPIFTTAIDDRCELSSPREDTIPIPSLTSCTETSDPLPTNENDDDICKKPCSVAPNDIPLVSSTNLINEINGVSEKLSATESIVEIVKQEVLPLTLELEILENPPEEMKLECIPAPITPSTVPSFPPTPPTPPASPPHTPVIVPAAATTVSSPSAAITVQRVLEEDESIRTCLSEDAKEIQNKIEVEADGQTEEILDSQNLNSRRSPVPAQIAITVPKTWKKPKDRTRTTEEMLEAELELKAEEELSIDKVLESEQDKMSQGFHPERDPSDLKKVKAVEENGEEAEPVRNGAESVSEGEGIDANSGSTDSSGDGVTFPFKPESWKPTDTEGKKQYDREFLLDFQFMPACIQKPEGLPPISDVVLDKINQPKLPMRTLDPRILPRGPDFTPAFADFGRQTPGGRGVPLLNVGSRRSQPGQRREPRKIITVSVKEDVHLKKAENAWKPSQKRDSQADDPENIKTQELFRKVRSILNKLTPQMFNQLMKQVSGLTVDTEERLKGVIDLVFEKAIDEPSFSVAYANMCRCLVTLKVPMADKPGNTVNFRKLLLNRCQKEFEKDKADDDVFEKKQKELEAASAPEERTRLHDELEEAKDKARRRSIGNIKFIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFNQMEKIVKERKTSSRIRFMLQDVIDLRLCNWVSRRADQGPKTIEQIHKEAKIEEQEEQRKVQQLMTKEKRRPGVQRVDEGGWNTVQGAKNSRVLDPSKFLKITKPTIDEKIQLVPKAQLGSWGKGSSGGAKASETDALRSSASSLNRFSALQPPAPSGSTPSTPVEFDSRRTLTSRGSMGREKNDKPLPSATARPNTFMRGGSSKDLLDNQSQEEQRREMLETVKQLTGGVDVERNSTEAERNKTRESAKPEISAMSAHDKAALSEEELERKSKSIIDEFLHINDFKEAMQCVEELNAQGLLHVFVRVGVESTLERSQITRDHMGQLLYQLVQSEKLSKQDFFKGFSETLELADDMAIDIPHIWLYLAELVTPMLKEGGISMRELTIEFSKPLLPVGRAGVLLSEILHLLCKQMSHKKVGALWREADLSWKDFLPEGEDVHNFLLEQKLDFIESDSPCSSEALSKKELSAEELYKRLEKLIIEDKANDEQIFDWVEANLDEIQMSSPTFLRALMTAVCKAAIIADSSTFRVDTAVIKQRVPILLKYLDSDTEKELQALYALQASIVKLDQPANLLRMFFDCLYDEEVISEDAFYKWESSKDPAEQNGKGVALKSVTAFFTWLREAEEESEDN
uniprot
proteins
function
FUNCTION: Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:9418880). Functional homolog of EIF4G1 (PubMed:9418880). {ECO:0000269|PubMed:9418880}.
uniprot
proteins
mass_dalton
176652
uniprot
proteins
mutagenesis
MUTAGEN 756; /note="R->D: Reduces binding to EIF4A; when associated with D-759 and D-764."; /evidence="ECO:0000269|PubMed:11172724"; MUTAGEN 759; /note="R->D: Reduces binding to EIF4A; when associated with D-756 and D-764."; /evidence="ECO:0000269|PubMed:11172724"; MUTAGEN 764; /note="K->D: Reduces binding to EIF4A; when associated with D-756 and D-759."; /evidence="ECO:0000269|PubMed:11172724"; MUTAGEN 814; /note="R->D: Reduces binding to EIF4A; when associated with D-820."; /evidence="ECO:0000269|PubMed:11172724"; MUTAGEN 820; /note="K->D: Reduces binding to EIF4A; when associated with D-814."; /evidence="ECO:0000269|PubMed:11172724"; MUTAGEN 834..835; /note="RK->DD: Reduces binding to IRES."; /evidence="ECO:0000269|PubMed:11172724
uniprot
proteins
post_translational_modification
PTM: Following infection by certain enteroviruses, rhinoviruses and aphthoviruses, EIF4G1 is cleaved by the viral protease 2A, or the leader protease in the case of aphthoviruses. This shuts down the capped cellular mRNA transcription. {ECO:0000269|PubMed:12663812, ECO:0000269|PubMed:15016848}.
uniprot
proteins
protein_family
Eukaryotic initiation factor 4G family
uniprot
proteins
pubmed
10872469
uniprot
proteins
pubmed
11172724
uniprot
proteins
pubmed
12663812
uniprot
proteins
pubmed
12975586
uniprot
proteins
pubmed
14507913
uniprot
proteins
pubmed
15016848
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17693683
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9418880
uniprot
proteins
pubmed
9857202
uniprot
proteins
sequence_length
1585
uniprot
proteins