SPC25
entrez
57405
canonical
uniprot
Q9HBM1
canonical
ensembl
ENSG00000152253
resolver
ensembl
ENSG00000277909
resolver
ensp
ENSP00000282074
resolver
ensp
ENSP00000481354
resolver
ensp
ENSP00000483050
resolver
ensp
ENSP00000531908
resolver
ensp
ENSP00000531909
resolver
ensp
ENSP00000600012
resolver
enst
ENST00000282074
resolver
enst
ENST00000611144
resolver
enst
ENST00000616584
resolver
enst
ENST00000861849
resolver
enst
ENST00000861850
resolver
enst
ENST00000929953
resolver
genesymbol
SPC25
resolver
genesymbol_syn
SPBC25
resolver
hgnc
HGNC:24031
resolver
uniprot
A8K4X8
resolver
uniprot
D3DPC0
resolver
uniprot_entry
SPC25_HUMAN
resolver
uniprot_sec
A8K4X8
resolver
uniprot_sec
D3DPC0
resolver
amino_acid_sequence
MVEDELALFDKSINEFWNKFKSTDTSCQMAGLRDTYKDSIKAFAEKLSVKLKEEERMVEMFLEYQNQISRQNKLIQEKKDNLLKLIAEVKGKKQELEVLTANIQDLKEEYSRKKETISTANKANAERLKRLQKSADLYKDRLGLEIRKIYGEKLQFIFTNIDPKNPESPFMFSLHLNEARDYEVSDSAPHLEGLAEFQENVRKTNNFSAFLANVRKAFTATVYN
uniprot
proteins
function
FUNCTION: Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity (PubMed:14699129, PubMed:14738735). Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (PubMed:14699129, PubMed:14738735). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (PubMed:23085020). {ECO:0000269|PubMed:14699129, ECO:0000269|PubMed:14738735, ECO:0000269|PubMed:23085020}.
uniprot
proteins
mass_dalton
26153
uniprot
proteins
protein_family
SPC25 family
uniprot
proteins
pubmed
14699129
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14738735
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
15961401
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23085020
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
224
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:14699129, ECO:0000269|PubMed:14738735, ECO:0000269|PubMed:15961401}. Note=Localizes to kinetochores from late prophase to anaphase (PubMed:14738735). Localizes specifically to the outer plate of the kinetochore (PubMed:14699129, PubMed:14738735). {ECO:0000269|PubMed:14699129, ECO:0000269|PubMed:14738735}.
uniprot
proteins