Stxbp4
entrez
20913
canonical
uniprot
Q9WV89
canonical
ensembl
ENSMUSG00000020546
resolver
ensp
ENSMUSP00000020858
resolver
ensp
ENSMUSP00000116191
resolver
ensp
ENSMUSP00000183946
resolver
ensp
ENSMUSP00000183947
resolver
genesymbol
Stxbp4
resolver
uniprot
Q5SUA6
resolver
uniprot
Q5SUA8
resolver
uniprot
Q5SUA9
resolver
uniprot
Q8CFL1
resolver
uniprot_entry
STXB4_MOUSE
resolver
uniprot_sec
Q5SUA6
resolver
uniprot_sec
Q5SUA8
resolver
uniprot_sec
Q5SUA9
resolver
uniprot_sec
Q8CFL1
resolver
amino_acid_sequence
MSDGTASARSSSPLDRDPAFRVITVTKETGLGLKILGGINRNEGPLVYIHEVIPGGDCYKDGRLKPGDQLVSINKESMIGVSFEEAKSIITRAKLRSESPWEIAFIRQKSYCGHPGNICCPSPQVSEDCGPQTSTFTLLSSPSETLLPKTSSTPQTQDSTFPSCKAIQTKPEHDKTEHSPITSLDNSPADTSNADIAPAWTDDDSGPQGKISLNPSVRLKAEKLEMALNYLGIQPTKEQREALREQVQADSKGTVSFGDFVQVARSLFCLQLDEVNVGVHEIPSILDSQLLPCDSLEADEVGKLRQERNAALEERNVLKEKLLESEKHRKQLIEELQNVKQEAKAVAEETRALRSRIHLAEAAQRQAHGMEMDYEEVIRLLEAEVSELKAQLADYSDQNKESVQDLRKRVTVLDCQLRKSEMARKAFKASTERLLGFIEAIQEVLLDSSAPLSTLSERRAVLASQTSLPLLARNGRSFPATLLLESKELVRSVRAILDMDCLPYGWEEAYTADGIKYFINHVTQTTSWIHPVMSALNLSCAEESEEDCPRELTDPKS
uniprot
proteins
function
FUNCTION: Plays a role in the translocation of transport vesicles from the cytoplasm to the plasma membrane. Inhibits the translocation of SLC2A4 from intracellular vesicles to the plasma membrane by STX4A binding and preventing the interaction between STX4A and VAMP2. Stimulation with insulin disrupts the interaction with STX4A, leading to increased levels of SLC2A4 at the plasma membrane. May also play a role in the regulation of insulin release by pancreatic beta cells after stimulation by glucose. {ECO:0000269|PubMed:10394363, ECO:0000269|PubMed:12855681}.
uniprot
proteins
mass_dalton
61689
uniprot
proteins
mutagenesis
MUTAGEN 97; /note="S->F: No effect."; /evidence="ECO:0000269|PubMed:15753124"; MUTAGEN 99; /note="S->F: Abolishes phosphorylation by PKB/AKT2."; /evidence="ECO:0000269|PubMed:15753124
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser-99 by PKB/AKT2 after insulin treatment. Phosphorylation on Ser-99 abolishes the interaction with STX4A. {ECO:0000269|PubMed:15753124}.
uniprot
proteins
pubmed
10394363
uniprot
proteins
pubmed
12855681
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15753124
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
557
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10394363}.
uniprot
proteins