Skp1
entrez
21402
canonical
uniprot
Q9WTX5
canonical
ensembl
ENSMUSG00000036309
resolver
ensp
ENSMUSP00000038744
resolver
ensp
ENSMUSP00000104700
resolver
enst
ENSMUST00000037324
resolver
enst
ENSMUST00000109072
resolver
genesymbol
Skp1
resolver
genesymbol_syn
Skp1a
resolver
uniprot
Q5SUR3
resolver
uniprot
Q8C5H6
resolver
uniprot_entry
Q5SUR3_MOUSE
resolver
uniprot_entry
SKP1_MOUSE
resolver
uniprot_sec
Q8C5H6
resolver
activity_regulation
ACTIVITY REGULATION: In oocytes and preimplantation embryos, SCF ubiquitin ligase complexes are maintained inactive by cytoplasmic lattices. {ECO:0000269|PubMed:41845018, ECO:0000269|PubMed:41917274, ECO:0000269|PubMed:41951593}.
uniprot
proteins
amino_acid_sequence
MPTIKLQSSDGEIFEVDVEIAKQSVTIKTMLEDLGMDDEGDDDPVPLPNVNAAILKKVIQWCTHHKDDPPPPEDDENKEKRTDDIPVWDQEFLKVDQGTLFELILAANYLDIKGLLDVTCKTVANMIKGKTPEEIRKTFNIKNDFTEEEEAQVRKENQWCEEK
uniprot
proteins
function
FUNCTION: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2 (By similarity). Core component of the Cul7-RING(FBXW8) ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Also acts as a core component of the Cul1-RING(FBXL4) ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of BNIP3 and BNIP3L (By similarity). {ECO:0000250|UniProtKB:P63208, ECO:0000269|PubMed:10097128, ECO:0000269|PubMed:12140560, ECO:0000269|PubMed:9990853}.
uniprot
proteins
mass_dalton
18672
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Undergoes autophagy-mediated degradation in the liver in a time-dependent manner. {ECO:0000269|PubMed:29937374}.
uniprot
proteins
protein_family
SKP1 family
uniprot
proteins
pubmed
10097128
uniprot
proteins
pubmed
11735228
uniprot
proteins
pubmed
12140560
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19996097
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23319590
uniprot
proteins
pubmed
29937374
uniprot
proteins
pubmed
41845018
uniprot
proteins
pubmed
41917274
uniprot
proteins
pubmed
41951593
uniprot
proteins
pubmed
9990853
uniprot
proteins
sequence_length
163
uniprot
proteins