Timd4
entrez
276891
canonical
uniprot
Q6U7R4
canonical
ensembl
ENSMUSG00000055546
resolver
ensp
ENSMUSP00000069456
resolver
ensp
ENSMUSP00000288806
resolver
ensp
ENSMUSP00000356572
resolver
enst
ENSMUST00000068877
resolver
genesymbol
Timd4
resolver
genesymbol_syn
Tim4
resolver
uniprot
Q6U7R3
resolver
uniprot
Q8CIC7
resolver
uniprot_entry
TIMD4_MOUSE
resolver
uniprot_sec
Q6U7R3
resolver
uniprot_sec
Q8CIC7
resolver
amino_acid_sequence
MSKGLLLLWLVTELWWLYLTPAASEDTIIGFLGQPVTLPCHYLSWSQSRNSMCWGKGSCPNSKCNAELLRTDGTRIISRKSTKYTLLGKVQFGEVSLTISNTNRGDSGVYCCRIEVPGWFNDVKKNVRLELRRATTTKKPTTTTRPTTTPYVTTTTPELLPTTVMTTSVLPTTTPPQTLATTAFSTAVTTCPSTTPGSFSQETTKGSAFTTESETLPASNHSQRSMMTISTDIAVLRPTGSNPGILPSTSQLTTQKTTLTTSESLQKTTKSHQINSRQTILIIACCVGFVLMVLLFLAFLLRGKVTGANCLQRHKRPDNTEDSDSVLNDMSHGRDDEDGIFTL
uniprot
proteins
function
FUNCTION: Phosphatidylserine receptor that plays different role in immune response including phagocytosis of apoptotic cells and T-cell regulation (PubMed:17960135, PubMed:18354194, PubMed:18367551, PubMed:20368430). Involved in efferocytosis, the process by which apoptotic cells are removed by phagocytic cells by promoting the engulfment of apoptotic cells or exogenous particles (PubMed:17960135, PubMed:20368430). Mechanistically, acts by securing apoptotic cells to phagocytes through direct binding to phosphatidylserine present on apoptotic cells, while other engulfment receptors such as MERTK efficiently recognize apoptotic cells and mediate their ingestion (PubMed:17960135). Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cell cycle arrest, while increasing proliferation of activated T-cells by activating AKT1 and ERK1/2 phosphorylations and subsequent signaling pathways (PubMed:18354194, PubMed:18367551). Also promotes autophagy process by suppressing NLRP3 inflammasome activity via activation of LKB1/PRKAA1 pathway in a phosphatidylserine-dependent mechanism (PubMed:31263038). {ECO:0000269|PubMed:17960135, ECO:0000269|PubMed:18354194, ECO:0000269|PubMed:18367551, ECO:0000269|PubMed:20368430, ECO:0000269|PubMed:31263038}.
uniprot
proteins
mass_dalton
37548
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
protein_family
TIM family
uniprot
proteins
pubmed
14768054
uniprot
proteins
pubmed
15793576
uniprot
proteins
pubmed
17960135
uniprot
proteins
pubmed
18083575
uniprot
proteins
pubmed
18354194
uniprot
proteins
pubmed
18367551
uniprot
proteins
pubmed
20368430
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31263038
uniprot
proteins
sequence_length
343
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q96H15}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 280..300; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins