Cd28
entrez
12487
canonical
uniprot
P31041
canonical
ensembl
ENSMUSG00000026012
resolver
ensp
ENSMUSP00000027165
resolver
enst
ENSMUST00000027165
resolver
genesymbol
Cd28
resolver
uniprot
Q6GSH7
resolver
uniprot
Q8CDB3
resolver
uniprot_entry
CD28_MOUSE
resolver
uniprot_entry
Q8CDB3_MOUSE
resolver
uniprot_sec
Q6GSH7
resolver
amino_acid_sequence
MTLRLLFLALNFFSVQVTENKILVKQSPLLVVDSNEVSLSCRYSYNLLAKEFRASLYKGVNSDVEVCVGNGNFTYQPQFRSNAEFNCDGDFDNETVTFRLWNLHVNHTDIYFCKIEFMYPPPYLDNERSNGTIIHIKEKHLCHTQSSPKLFWALVVVAGVLFCYGLLVTVALCVIWTNSRRNRLLQSDYMNMTPRRPGLTRKPYQPYAPARDFAAYRP
uniprot
proteins
function
FUNCTION: Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis (PubMed:7688139). Functions not only as an amplifier of TCR signals but delivers unique signals that control intracellular biochemical events that alter the gene expression program of T-cells. Stimulation upon engagement of its cognate ligands CD80 or CD86 increases proliferation and expression of various cytokines in particular IL2 production in both CD4(+) and CD8(+) T-cell subsets. Mechanistically, ligation induces recruitment of protein kinase C-theta/PRKCQ and GRB2 leading to NF-kappa-B activation via both PI3K/Akt-dependent and -independent pathways. In conjunction with TCR/CD3 ligation and CD40L costimulation, enhances the production of IL4 and IL10 in T-cells. {ECO:0000250|UniProtKB:P10747, ECO:0000269|PubMed:7688139}.
uniprot
proteins
mass_dalton
25243
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by LCK (PubMed:27460989). Dephosphorylated by PTPN11 (By similarity). {ECO:0000250|UniProtKB:P10747, ECO:0000269|PubMed:27460989}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1713603
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
2157764
uniprot
proteins
pubmed
27460989
uniprot
proteins
pubmed
7688139
uniprot
proteins
sequence_length
218
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27460989}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P10747}.
uniprot
proteins
transmembrane_region
TRANSMEM 151..177; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins