Q62953
uniprot
Q62953
canonical
amino_acid_sequence
YCYICHSLQYNADLQPANTCIYLVVTWVMTVLDVLPNVYIGTIEYDPRTYTCYFNYVNNPAFTVTIVCIHFVLPLIIVGYCYTKIWIKVLADRDPAGQNPDNQFAEVRNFLTMFVIFLL
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that plays a role in numerous physiological processes including regulation of energy metabolism, neurite outgrowth or cell migration (By similarity). Promotes self-renewal and neuronal differentiation of neural progenitor cells through activation of the NOTCH and WNT/beta-catenin signaling pathways (By similarity). Modulates the KAT5-dependent glucocorticoid receptor signaling by modulating KAT5 subcellular compartmentalization. Plays also a role in the activation TGFBR1 in the absence of TGFBR2 by interfering with FKBP1A binding to TGFBR1, leading to induction of both canonical and non-canonical SMAD signaling pathways resulting in inhibition of proliferation or promotion of migration (By similarity). {ECO:0000250|UniProtKB:O88495, ECO:0000250|UniProtKB:Q13585}.
uniprot
proteins
mass_dalton
13837
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
8647286
uniprot
proteins
sequence_length
119
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q13585}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q13585}. Postsynaptic density {ECO:0000250|UniProtKB:Q13585}.
uniprot
proteins
transmembrane_region
TRANSMEM 18..38; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 63..83; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 114..>119; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins