Pcif1
entrez
228866
canonical
uniprot
P59114
canonical
ensembl
ENSMUSG00000039849
resolver
ensp
ENSMUSP00000039555
resolver
ensp
ENSMUSP00000221726
resolver
ensp
ENSMUSP00000221731
resolver
ensp
ENSMUSP00000221735
resolver
enst
ENSMUST00000041643
resolver
genesymbol
Pcif1
resolver
uniprot
Q542C3
resolver
uniprot_entry
CAPAM_MOUSE
resolver
uniprot_entry
Q542C3_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Cap-specific adenosine methyltransferase activity is inhibited by zinc. {ECO:0000250|UniProtKB:Q9H4Z3}.
uniprot
proteins
amino_acid_sequence
MANENHGSPREGASLLSHSPGTSSQSQPCSPKPVRLVQDLPEELVHAGWEKCWSRRESRPYYFNRFTNQSLWEMPVLGQHDVLSDPLGLNATPLPQDSSLVETPPVENKSRKRQLSEEQPSGNGVKKPKIEIPVTPTSQSVPSSPSIPGTPTLKIWGSSTEDKQAALLRPTEVYWDLDIQTNAVIKHRGPSEVLPPHPDVELLRSQLILKLRQHYRELCQQREGIEPPRESFNRWMLERKVVDKGCDPLLPSNCEPVVSPSMFREIMNDIPIRLSRIKFREEAKRLLFKYAEAARRLIESRSASPDSRKVVKWNVEDTFSWLRKEHSASKEDYMDRLEHLRRQCGPHVSAAAKDSVEGICSKIYHISLEYVKRIREKHLAVLKENNIPEEVEASELEPRLVYCYPVRLAVSAPPMPSVEMHVENSVVCIRYKGEMVKVSRSYFSKLWLLYRYSCVDDSAFERFLPRVWCLLRRYQMMFGVGLYEGTGLQGSLPVHVFETLHRLFGVSFECFASPLNCYFRQYCSAFPDTDGYFGSRGPCLDFTPLSGSFEANPPFCEELMDAMVSHFEKLLESSAEPLSFIVFIPEWREPPTPALTRMEQSRFKRHQLVLPAFEHEYRSGSQHICKKEEMHYKAVHNTAVLFLQNGPGFAKWGPTPERLQELTAAYKQSGRSHGSSSSSSSSSSSSEAKDRDSGREQGPSREPHPT
uniprot
proteins
ec_number
2.1.1.62
uniprot
proteins
function
FUNCTION: Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2'-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs (PubMed:30487554). Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally (By similarity). {ECO:0000250|UniProtKB:Q9H4Z3, ECO:0000269|PubMed:30487554}.
uniprot
proteins
mass_dalton
80504
uniprot
proteins
protein_family
CAPAM family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30487554
uniprot
proteins
sequence_length
706
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H4Z3}.
uniprot
proteins