Casq2
entrez
12373
canonical
uniprot
O09161
canonical
ensembl
ENSMUSG00000027861
resolver
ensp
ENSMUSP00000029454
resolver
ensp
ENSMUSP00000130482
resolver
enst
ENSMUST00000029454
resolver
enst
ENSMUST00000165540
resolver
genesymbol
Casq2
resolver
uniprot
F6QYE1
resolver
uniprot
O88505
resolver
uniprot
Q56A03
resolver
uniprot_entry
CASQ2_MOUSE
resolver
uniprot_entry
F6QYE1_MOUSE
resolver
uniprot_sec
O88505
resolver
uniprot_sec
Q56A03
resolver
amino_acid_sequence
MKRIYLLMVGVYLLSLSGAEEGLNFPTYDGKDRVVSLSEKNLKQMLKRYDLLCLYYHEPVSSDKVSQKQFQLKEIVLELVAQVLEHKNIGFVMVDSRKEAKLAKRLGFSEEGSLYVLKGDRTIEFDGEFAADVLVEFLLDLIEDPVEIVNNKLEVQAFERIEDQTKLLGFFKNEDSEYYKAFQEAAEHFQPYIKFFATFDKAVAKKLSLKMNEVGFYEPFMDEPNVIPNKPYTEEELVEFVKEHQRPTLRRLRPEDMFETWEDDLNGIHIVAFAEKSDPDGYEFLEILKQVARDNTDNPDLSILWIDPDDFPLLVAYWEKTFKIDLFKPQIGVVNVTDADSIWMEIPDDDDLPTAEELEDWIEDVLSGKINTEDDDNEDEDDDGDDNDDDDDDDDDNDNSDEDNEDSDDDDDDDE
uniprot
proteins
function
FUNCTION: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, especially at the interface between subunits. Can bind around 60 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR2; this plays an important role in triggering muscle contraction. Plays a role in excitation-contraction coupling in the heart and in regulating the rate of heart beats. {ECO:0000269|PubMed:16932808, ECO:0000269|PubMed:17607358, ECO:0000269|PubMed:19920148}.
uniprot
proteins
mass_dalton
48176
uniprot
proteins
mutagenesis
MUTAGEN 307; /note="D->H: Impairs calcium-dependent oligomerization and promotes ventricular tachycardia."; /evidence="ECO:0000269|PubMed:17607358, ECO:0000269|PubMed:19920148
uniprot
proteins
post_translational_modification
PTM: Phosphorylation in the C-terminus moderately increases calcium buffering capacity. {ECO:0000250|UniProtKB:O14958}.; PTM: N-glycosylated. {ECO:0000250|UniProtKB:O14958}.
uniprot
proteins
protein_family
Calsequestrin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16932808
uniprot
proteins
pubmed
17607358
uniprot
proteins
pubmed
19920148
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9795116
uniprot
proteins
sequence_length
415
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Sarcoplasmic reticulum lumen {ECO:0000269|PubMed:16932808, ECO:0000269|PubMed:19920148}. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of cardiac and slow skeletal muscle cells. {ECO:0000269|PubMed:16932808, ECO:0000269|PubMed:19920148}.
uniprot
proteins