Dao
entrez
114027
canonical
uniprot
O35078
canonical
ensembl
ENSRNOG00000054962
resolver
ensp
ENSRNOP00000079300
resolver
enst
ENSRNOT00000094356
resolver
genesymbol
Dao
resolver
genesymbol_syn
Dao1
resolver
uniprot_entry
OXDA_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by benzoate, anthranilate and luvadaxistat (PubMed:21981077, PubMed:37289348). Inhibited by 3-hydroxyquinolin-2(1h)-one, 4-hydroxy-6-[2-(7-hydroxy-2-oxo-4-phenyl-2h-chromen-6- Yl)ethyl]pyridazin-3(2h)-one and 3-(7-hydroxy-2-oxo-4-phenyl-2h-chromen-6-Yl)propanoic acid (PubMed:19438227, PubMed:25001371). {ECO:0000269|PubMed:19438227, ECO:0000269|PubMed:21981077, ECO:0000269|PubMed:25001371, ECO:0000269|PubMed:37289348}.
uniprot
proteins
amino_acid_sequence
MRVAVIGAGVIGLSTALCIHERYHPAQPLHMKIYADRFTPFTTSDVAAGLWQPYLSDPSNPQEAEWNQQTFDHLQSCLHSPNAEKMGLALISGYNLFRDEVPDPFWKSTVLGFRKLTPSELDMFPDYSYGWFNTSLLLEGKSYLSWLTERLTERGVKFIHRKVASFEEVVRGGVDVIINCTGVWAGALQADASLQPGRGQIIQVEAPWIKHFILTHDPSLGIYNSPYIIPGSKTVTLGGVFQLGNWSELNSVHDHNTIWKSCCQLEPTLKNARIMGELTGFRPVRPQVRLERERLRFGSSSAEVIHNYGHGGYGLTIHWGCAMEAANLFGKILEEKNLSRMPPSHL
uniprot
proteins
ec_number
1.4.3.3
uniprot
proteins
function
FUNCTION: Catalyzes the oxidative deamination of D-amino acids with broad substrate specificity (PubMed:21700703, PubMed:21981077). Required to catabolize D-amino acids synthesized endogenously, of gastrointestinal bacterial origin or obtained from the diet, and to use these as nutrients (By similarity). Regulates the level of D-amino acid neurotransmitters in the brain, such as D-serine, a co-agonist of N-methyl D-aspartate (NMDA) receptors, and may modulate synaptic transmission (PubMed:23631755). Catalyzes the first step of the racemization of D-DOPA to L-DOPA, for possible use in an alternative dopamine biosynthesis pathway (By similarity). Also catalyzes the first step of the chiral inversion of N(gamma)-nitro-D-arginine methyl ester (D-NNA) to its L-enantiomer L-NNA that acts as a nitric oxide synthase inhibitor (By similarity). The hydrogen peroxide produced in the reaction provides protection against microbial infection; it contributes to the oxidative killing activity of phagocytic leukocytes and protects against bacterial colonization of the small intestine (By similarity). Enzyme secreted into the lumen of the intestine may not be catalytically active and could instead be proteolytically cleaved into peptides with antimicrobial activity (By similarity). The hydrogen peroxide produced in the reaction may also play a role in promoting cellular senescence in response to DNA damage (By similarity). Could act as a detoxifying agent which removes D-amino acids accumulated during aging (PubMed:7903300). {ECO:0000250|UniProtKB:P14920, ECO:0000250|UniProtKB:P18894, ECO:0000269|PubMed:21700703, ECO:0000269|PubMed:21981077, ECO:0000269|PubMed:23631755, ECO:0000269|PubMed:7903300}.
uniprot
proteins
mass_dalton
38820
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in the cerebellum; probably not by PRKACA, PRKCA or PRKCE. {ECO:0000250|UniProtKB:P14920}.; PTM: May be S-nitrosylated, which partially inactivates the enzyme. {ECO:0000250|UniProtKB:P14920}.
uniprot
proteins
protein_family
DAMOX/DASOX family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17880399
uniprot
proteins
pubmed
19438227
uniprot
proteins
pubmed
20564560
uniprot
proteins
pubmed
21700703
uniprot
proteins
pubmed
21981077
uniprot
proteins
pubmed
23631755
uniprot
proteins
pubmed
25001371
uniprot
proteins
pubmed
26961980
uniprot
proteins
pubmed
2896644
uniprot
proteins
pubmed
37289348
uniprot
proteins
pubmed
37440119
uniprot
proteins
pubmed
7903300
uniprot
proteins
pubmed
9473656
uniprot
proteins
sequence_length
346
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome matrix {ECO:0000269|PubMed:26961980, ECO:0000269|PubMed:2896644}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P14920}. Presynaptic active zone {ECO:0000269|PubMed:21700703}. Secreted {ECO:0000250|UniProtKB:P18894}. Note=Transiently present in the cytosol before being delivered to the peroxisomes (By similarity). In the cerebellum, a fraction of protein localizes to the presynaptic active zone, where its activity is regulated by protein BSN (PubMed:21700703). Secreted into the lumen of the small intestine (By similarity). {ECO:0000250|UniProtKB:P14920, ECO:0000250|UniProtKB:P18894, ECO:0000269|PubMed:21700703}.
uniprot
proteins