Sertad2
entrez
58172
canonical
uniprot
Q9JJG5
canonical
ensembl
ENSMUSG00000049800
resolver
ensp
ENSMUSP00000090981
resolver
ensp
ENSMUSP00000105214
resolver
ensp
ENSMUSP00000105215
resolver
ensp
ENSMUSP00000363007
resolver
enst
ENSMUST00000093292
resolver
enst
ENSMUST00000109585
resolver
enst
ENSMUST00000109586
resolver
genesymbol
Sertad2
resolver
genesymbol_syn
Kiaa0127
resolver
uniprot
Q3UGZ1
resolver
uniprot
Q8C609
resolver
uniprot
Q91WL3
resolver
uniprot
Q925E5
resolver
uniprot_entry
Q3UGZ1_MOUSE
resolver
uniprot_entry
SRTD2_MOUSE
resolver
uniprot_sec
Q8C609
resolver
uniprot_sec
Q91WL3
resolver
uniprot_sec
Q925E5
resolver
amino_acid_sequence
MLGKGGKRKFDEHEDGLEGKIVSPSDGPSRVSYTLQRQTIFNISLMKLYNHRPLTEPSLQKTVLINNMLRRIQEELKQEGSLRPAFTPSSQPSNSLSDSYQEAPPPAPHPCDLGSTTPLEACLTPASLLEDDNDDTFCTLQAVHPAAPTRLSSAALPAEKDSFSSALDEIEELCPTSTSTEAAHTAAPEGPKGTSSESSVQKPEGPEEGRTDDSRFMDSLPGNFEITTSTGFLTDLTLDDILFADIDTSMYDFDPCTSASGTASKMAPVSADDLLKTLAPYSNQPVAPSQPFKMDLTELDHIMEVLVGS
uniprot
proteins
function
FUNCTION: Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism. {ECO:0000269|PubMed:23291629}.
uniprot
proteins
mass_dalton
33312
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated, which promotes proteasomal degradation. {ECO:0000250}.
uniprot
proteins
pubmed
11331592
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23291629
uniprot
proteins
sequence_length
309
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Exported out of the nucleus via its NES in a XPO1-dependent manner. Once in the cytoplasm, is degraded by the proteasome (By similarity). {ECO:0000250}.
uniprot
proteins