Cadm1
entrez
54725
canonical
uniprot
Q8R5M8
canonical
ensembl
ENSMUSG00000032076
resolver
ensp
ENSMUSP00000034581
resolver
ensp
ENSMUSP00000083073
resolver
ensp
ENSMUSP00000110194
resolver
ensp
ENSMUSP00000110195
resolver
ensp
ENSMUSP00000124119
resolver
ensp
ENSMUSP00000124555
resolver
enst
ENSMUST00000152459
resolver
genesymbol
Cadm1
resolver
genesymbol_syn
Igsf4
resolver
genesymbol_syn
Necl2
resolver
genesymbol_syn
Ra175
resolver
genesymbol_syn
SynCam1
resolver
genesymbol_syn
Syncam
resolver
genesymbol_syn
Tslc1
resolver
uniprot
E9PYN1
resolver
uniprot
J7IJ87
resolver
uniprot
Q6F3J3
resolver
uniprot
Q7TNL1
resolver
uniprot
Q80VG4
resolver
uniprot
Q8K3T6
resolver
uniprot
Q8R4L1
resolver
uniprot
Q9QYL5
resolver
uniprot
Q9QYL6
resolver
uniprot
Q9Z2H8
resolver
uniprot_entry
CADM1_MOUSE
resolver
uniprot_entry
E9PYN1_MOUSE
resolver
uniprot_entry
J7IJ87_MOUSE
resolver
uniprot_sec
Q6F3J3
resolver
uniprot_sec
Q7TNL1
resolver
uniprot_sec
Q80VG4
resolver
uniprot_sec
Q8K3T6
resolver
uniprot_sec
Q8R4L1
resolver
uniprot_sec
Q9QYL5
resolver
uniprot_sec
Q9QYL6
resolver
uniprot_sec
Q9Z2H8
resolver
amino_acid_sequence
MASAVLPSGSQCAAAAAVAAAAAPPGLRLRLLLLLLSAAALIPTGDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQLLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMIDIQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNKELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHPAVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDAFELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFINNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILTIITDTTATTEPAVHDSRAGEEGTIGAVDHAVIGGVVAVVVFAMLCLLIILGRYFARHKGTYFTHEAKGADDAADADTAIINAEGGQNNSEEKKEYFI
uniprot
proteins
function
FUNCTION: Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner (PubMed:12202822, PubMed:12799182, PubMed:12826663). Also mediates heterophilic cell-cell adhesion with CADM3 and NECTIN3 in a Ca(2+)-independent manner (PubMed:12826663). Interaction with CRTAM promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952). In mast cells, may mediate attachment to and promote communication with nerves (By similarity). CADM1, together with MITF, is essential for development and survival of mast cells in vivo (PubMed:15158462, PubMed:16605125). By interacting with CRTAM and thus promoting the adhesion between CD8+ T-cells and CD8+ dendritic cells, regulates the retention of activated CD8+ T-cell within the draining lymph node (PubMed:19752223). Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (PubMed:24687959). Interaction with CRTAM promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (PubMed:24687959). Acts as a synaptic cell adhesion molecule and plays a role in the formation of dendritic spines and in synapse assembly (PubMed:12202822, PubMed:23209303). May be involved in neuronal migration, axon growth, pathfinding, and fasciculation on the axons of differentiating neurons (PubMed:15707673). May play diverse roles in the spermatogenesis including in the adhesion of spermatocytes and spermatids to Sertoli cells and for their normal differentiation into mature spermatozoa (PubMed:12606335, PubMed:16612000). {ECO:0000250|UniProtKB:Q9BY67, ECO:0000269|PubMed:12202822, ECO:0000269|PubMed:12606335, ECO:0000269|PubMed:12799182, ECO:0000269|PubMed:12826663, ECO:0000269|PubMed:15158462, ECO:0000269|PubMed:15707673, ECO:0000269|PubMed:15811952, ECO:0000269|PubMed:16605125, ECO:0000269|PubMed:16612000, ECO:0000269|PubMed:19752223, ECO:0000269|PubMed:23209303, ECO:0000269|PubMed:24687959}.
uniprot
proteins
mass_dalton
49788
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:12606335, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:19656770, ECO:0000269|PubMed:20739279}.; PTM: Glycosylation at Asn-70 and Asn-104 promotes adhesive binding and synapse induction. {ECO:0000250}.
uniprot
proteins
protein_family
Nectin family
uniprot
proteins
pubmed
12202822
uniprot
proteins
pubmed
12242005
uniprot
proteins
pubmed
12606335
uniprot
proteins
pubmed
12799182
uniprot
proteins
pubmed
12826663
uniprot
proteins
pubmed
15158462
uniprot
proteins
pubmed
15707673
uniprot
proteins
pubmed
15781451
uniprot
proteins
pubmed
15811952
uniprot
proteins
pubmed
15893517
uniprot
proteins
pubmed
16382161
uniprot
proteins
pubmed
16605125
uniprot
proteins
pubmed
16611999
uniprot
proteins
pubmed
16612000
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
19752223
uniprot
proteins
pubmed
20739279
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23209303
uniprot
proteins
pubmed
24687959
uniprot
proteins
sequence_length
456
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12826663, ECO:0000269|PubMed:19752223, ECO:0000269|PubMed:20739279, ECO:0000269|PubMed:24687959}; Single-pass type I membrane protein {ECO:0000269|PubMed:12826663, ECO:0000269|PubMed:20739279}. Synaptic cell membrane {ECO:0000269|PubMed:20739279, ECO:0000269|PubMed:23209303}; Single-pass type I membrane protein {ECO:0000305}. Note=Localized to the basolateral plasma membrane of epithelial cells in gall bladder. {ECO:0000269|PubMed:12826663}.
uniprot
proteins
transmembrane_region
TRANSMEM 389..409; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins