LSM1
entrez
27257
canonical
uniprot
O15116
canonical
ensembl
ENSG00000175324
resolver
ensp
ENSP00000310596
resolver
enst
ENST00000311351
resolver
genesymbol
LSM1
resolver
genesymbol_syn
CASM
resolver
hgnc
HGNC:20472
resolver
uniprot
A0A0S2Z590
resolver
uniprot
B2R5E6
resolver
uniprot_entry
A0A0S2Z590_HUMAN
resolver
uniprot_entry
LSM1_HUMAN
resolver
uniprot_sec
B2R5E6
resolver
amino_acid_sequence
MNYMPGTASLIEDIDKKHLVLLRDGRTLIGFLRSIDQFANLVLHQTVERIHVGKKYGDIPRGIFVVRGENVVLLGEIDLEKESDTPLQQVSIEEILEEQRVEQQTKLEAEKLKVQALKDRGLSIPRADTLDEY
uniprot
proteins
disease_involvement
DISEASE: FICUS syndrome (FICUS) [MIM:621193]: An autosomal recessive disorder characterized by facial dysmorphism, impaired intellectual development, global developmental delay, and multisystem features including cardiovascular, urogenital, skeletal, gastrointestinal, and ophthalmologic abnormalities. {ECO:0000269|PubMed:31010896, ECO:0000269|PubMed:36100156, ECO:0000269|PubMed:40204357}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated (PubMed:18172165). Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation (By similarity). {ECO:0000250|UniProtKB:P47017, ECO:0000269|PubMed:18172165}.
uniprot
proteins
mass_dalton
15179
uniprot
proteins
protein_family
SnRNP Sm proteins family
uniprot
proteins
pubmed
10369684
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18172165
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
31010896
uniprot
proteins
pubmed
36100156
uniprot
proteins
pubmed
40204357
uniprot
proteins
pubmed
9230209
uniprot
proteins
sequence_length
133
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:18172165}. Cytoplasm, P-body {ECO:0000305|PubMed:18172165}.
uniprot
proteins