Glmn
entrez
170823
canonical
uniprot
Q8BZM1
canonical
ensembl
ENSMUSG00000029276
resolver
ensp
ENSMUSP00000077168
resolver
ensp
ENSMUSP00000080766
resolver
ensp
ENSMUSP00000098509
resolver
ensp
ENSMUSP00000276801
resolver
enst
ENSMUST00000078021
resolver
enst
ENSMUST00000082121
resolver
enst
ENSMUST00000100949
resolver
genesymbol
Glmn
resolver
genesymbol_syn
Fap48
resolver
uniprot
F6XNI0
resolver
uniprot
Q3T9A5
resolver
uniprot
Q3TFR5
resolver
uniprot
Q99LB8
resolver
uniprot_entry
F6XNI0_MOUSE
resolver
uniprot_entry
GLMN_MOUSE
resolver
uniprot_entry
Q3T9A5_MOUSE
resolver
uniprot_sec
Q3TFR5
resolver
uniprot_sec
Q99LB8
resolver
amino_acid_sequence
MAVEELQSIIKRCQILEEHDFKEEDFGLFQLAGQRCIEDGYINQLLEIIQDEKNKTIIKSMGWNLVGPVVRCLLRGREEDKREECFLIFDLLVKLCNPKELLLGLLELIEEPSGKQISQIILLLLQPLQTVIQKLPNNKAYSVGLALSTLWSQLSLLPVPHSEEQIQADDYGLCQCCKALIEFTKPFVEEVISDKENKENAKLKDELLKFCFKGLKCPLLTAQFLEQSEDVGNDPFRCFASEIIGFLSKIGHPVPQIILNHGRKKRTWDYLEFEEEEDKQLAESVASLTYLVFVQGIGIDQLPMVLSPSYLLQLNMEHIEVFLQRTEQSIYSKGLELLETSLLRLEDNSLCYQYLEIKSFLAVPQGLVKVMTLCPIETLRKKGLSMLQLFIDKLDSQGKYTLFRCLLNTSNHSGVEAFVIQNIKNQIDLSFKKTYNKWFAGAQLISLLDLVLSLPEGAETDLLQNSDRIMASLNLLRYLVIKDNEDDNQTGLWTELGKIENNFLKPLHIGLNMSKAHYEAEIKNSQQNNQVASMCKGVCSVTVGGEEIPSMPPEMQLKVLHSALFTFDLIESVLARVEELIEIKSKSTSEENVGIK
uniprot
proteins
function
FUNCTION: Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase complexes. Inhibits E3 ubiquitin ligase activity by binding to the RING domain of RBX1 and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34. Inhibits RBX1-mediated neddylation of CUL1 (By similarity). Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thereby contributes to the regulation of CCNE1 and MYC levels (PubMed:22405651). Essential for normal development of the vasculature (PubMed:22405651). Contributes to the regulation of RPS6KB1 phosphorylation (By similarity). {ECO:0000250|UniProtKB:Q92990, ECO:0000269|PubMed:22405651}.
uniprot
proteins
mass_dalton
67756
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues. {ECO:0000250|UniProtKB:Q92990}.
uniprot
proteins
pubmed
15053987
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22405651
uniprot
proteins
sequence_length
596
uniprot
proteins