Phb1
entrez
18673
canonical
uniprot
P67778
canonical
ensembl
ENSMUSG00000038845
resolver
ensp
ENSMUSP00000119603
resolver
enst
ENSMUST00000125172
resolver
genesymbol
Phb1
resolver
genesymbol_syn
Phb
resolver
uniprot
P24142
resolver
uniprot
Q3UB75
resolver
uniprot
Q5SQG4
resolver
uniprot_entry
PHB1_MOUSE
resolver
uniprot_sec
P24142
resolver
uniprot_sec
Q3UB75
resolver
uniprot_sec
Q5SQG4
resolver
activity_regulation
ACTIVITY REGULATION: Target of the anti-cancer drug Rocaglamide (Roc-A). {ECO:0000269|PubMed:29324904}.
uniprot
proteins
amino_acid_sequence
MAAKVFESIGKFGLALAVAGGVVNSALYNVDAGHRAVIFDRFRGVQDIVVGEGTHFLIPWVQKPIIFDCRSRPRNVPVITGSKDLQNVNITLRILFRPVASQLPRIYTSIGEDYDERVLPSITTEILKSVVARFDAGELITQRELVSRQVSDDLTERAATFGLILDDVSLTHLTFGKEFTEAVEAKQVAQQEAERARFVVEKAEQQKKAAIISAEGDSKAAELIANSLATAGDGLIELRKLEAAEDIAYQLSRSRNITYLPAGQSVLLQLPQ
uniprot
proteins
function
FUNCTION: Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors in the nucleus (PubMed:11302691, PubMed:20959514, PubMed:23241883, PubMed:24856930, PubMed:29324904). Plays a role in adipose tissue and glucose homeostasis in a sex-specific manner (PubMed:24947361). Contributes to pulmonary vascular remodeling by accelerating proliferation of pulmonary arterial smooth muscle cells (By similarity). {ECO:0000250|UniProtKB:P67779, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:23241883, ECO:0000269|PubMed:24856930, ECO:0000269|PubMed:24947361, ECO:0000269|PubMed:29324904}.; FUNCTION: In the mitochondria, together with PHB2, forms large ring complexes (prohibitin complexes) in the inner mitochondrial membrane (IMM) and functions as a chaperone protein that stabilizes mitochondrial respiratory enzymes and maintains mitochondrial integrity in the IMM, which is required for mitochondrial morphogenesis, neuronal survival, and normal lifespan (Probable). The prohibitin complex, with DNAJC19, regulates cardiolipin remodeling and the protein turnover of OMA1 in a cardiolipin-binding manner (PubMed:24856930). Regulates mitochondrial respiration activity playing a role in cellular aging (PubMed:11302691). The prohibitin complex plays a role of mitophagy receptor involved in targeting mitochondria for autophagic degradation (PubMed:31819158). Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and pro-inflammatory cytokine IL6 (By similarity). {ECO:0000250|UniProtKB:P35232, ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:24856930, ECO:0000269|PubMed:31819158, ECO:0000305}.; FUNCTION: In the nucleus, acts as a transcription coregulator, enhances promoter binding by TP53, a transcription factor it activates, but reduces the promoter binding by E2F1, a transcription factor it represses (By similarity). Interacts with STAT3 to affect IL17 secretion in T-helper Th17 cells (By similarity). {ECO:0000250|UniProtKB:P35232}.; FUNCTION: In the plasma membrane, cooperates with CD86 to mediate CD86-signaling in B lymphocytes that regulates the level of IgG1 produced through the activation of distal signaling intermediates (PubMed:23241883). Upon CD40 engagement, required to activate NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (PubMed:23241883). {ECO:0000269|PubMed:23241883}.; FUNCTION: (Microbial infection) In neuronal cells, cell surface-expressed PHB1 is involved in human enterovirus 71/EV-71 entry into neuronal cells specifically, while membrane-bound mitochondrial PHB1 associates with the virus replication complex and facilitates viral replication (PubMed:29324904). May serve as a receptor for EV71 (PubMed:29324904). {ECO:0000269|PubMed:29324904}.
uniprot
proteins
mass_dalton
29820
uniprot
proteins
protein_family
Prohibitin family
uniprot
proteins
pubmed
11302691
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20959514
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23241883
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
24856930
uniprot
proteins
pubmed
24947361
uniprot
proteins
pubmed
29324904
uniprot
proteins
pubmed
31819158
uniprot
proteins
pubmed
8070406
uniprot
proteins
sequence_length
272
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:11302691, ECO:0000269|PubMed:20959514, ECO:0000269|PubMed:29324904}. Nucleus {ECO:0000269|PubMed:20959514}. Cell membrane {ECO:0000305|PubMed:29324904}. Cytoplasm {ECO:0000269|PubMed:29324904}.
uniprot
proteins