LAMTOR4
entrez
389541
canonical
uniprot
Q0VGL1
canonical
ensembl
ENSG00000188186
resolver
ensp
ENSP00000343118
resolver
ensp
ENSP00000477680
resolver
ensp
ENSP00000479176
resolver
ensp
ENSP00000740549
resolver
enst
ENST00000341942
resolver
enst
ENST00000460732
resolver
enst
ENST00000474141
resolver
genesymbol
LAMTOR4
resolver
genesymbol_syn
C7orf59
resolver
hgnc
HGNC:33772
resolver
uniprot
A0A087WT92
resolver
uniprot
A0A087WV46
resolver
uniprot_entry
A0A087WT92_HUMAN
resolver
uniprot_entry
A0A087WV46_HUMAN
resolver
uniprot_entry
LTOR4_HUMAN
resolver
amino_acid_sequence
MTSALTQGLERIPDQLGYLVLSEGAVLASSGDLENDEQAASAISELVSTACGFRLHRGMNVPFKRLSVVFGEHTLLVTVSGQRVFVVKRQNRGREPIDV
uniprot
proteins
function
FUNCTION: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:22980980, PubMed:28935770, PubMed:29107538, PubMed:29158492, PubMed:30181260). Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator plays a dual role for the small GTPases Rag (RagA/RRAGA, RagB/RRAGB, RagC/RRAGC and/or RagD/RRAGD): it (1) acts as a guanine nucleotide exchange factor (GEF), activating the small GTPases Rag and (2) mediates recruitment of Rag GTPases to the lysosome membrane (PubMed:22053050, PubMed:22980980, PubMed:28935770, PubMed:29107538, PubMed:29158492, PubMed:30181260). Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated (PubMed:22980980, PubMed:28935770, PubMed:29107538, PubMed:29158492, PubMed:30181260). {ECO:0000269|PubMed:22053050, ECO:0000269|PubMed:22980980, ECO:0000269|PubMed:28935770, ECO:0000269|PubMed:29107538, ECO:0000269|PubMed:29158492, ECO:0000269|PubMed:30181260}.
uniprot
proteins
mass_dalton
10741
uniprot
proteins
mutagenesis
MUTAGEN 34..35; /note="EN->AA: Does not affect Ragulator complex assembly."; /evidence="ECO:0000269|PubMed:31314152"; MUTAGEN 36..37; /note="DE->AA: Does not affect Ragulator complex assembly."; /evidence="ECO:0000269|PubMed:31314152"; MUTAGEN 67; /note="S->D: Mimics phosphorylation; inhibiting Ragulator complex assembly."; /evidence="ECO:0000269|PubMed:31314152
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-67 by PKA inhibits Ragulator complex assembly. {ECO:0000269|PubMed:31314152}.
uniprot
proteins
protein_family
LAMTOR4 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22053050
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
22980980
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25561175
uniprot
proteins
pubmed
25567906
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28935770
uniprot
proteins
pubmed
29107538
uniprot
proteins
pubmed
29123114
uniprot
proteins
pubmed
29158492
uniprot
proteins
pubmed
29285400
uniprot
proteins
pubmed
30181260
uniprot
proteins
pubmed
31314152
uniprot
proteins
pubmed
31601708
uniprot
proteins
pubmed
31672913
uniprot
proteins
pubmed
31704029
uniprot
proteins
pubmed
32868926
uniprot
proteins
pubmed
35338845
uniprot
proteins
pubmed
36103527
uniprot
proteins
pubmed
36697823
uniprot
proteins
sequence_length
99
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:22980980}.
uniprot
proteins