EDA2R
entrez
60401
canonical
uniprot
Q9HAV5
canonical
ensembl
ENSG00000131080
resolver
ensp
ENSP00000253392
resolver
ensp
ENSP00000363851
resolver
ensp
ENSP00000379365
resolver
ensp
ENSP00000415242
resolver
ensp
ENSP00000572789
resolver
ensp
ENSP00000614302
resolver
ensp
ENSP00000643129
resolver
ensp
ENSP00000643130
resolver
ensp
ENSP00000700949
resolver
ensp
ENSP00000700950
resolver
ensp
ENSP00000700951
resolver
ensp
ENSP00000700954
resolver
ensp
ENSP00000700955
resolver
ensp
ENSP00000759946
resolver
ensp
ENSP00000759948
resolver
ensp
ENSP00000759950
resolver
ensp
ENSP00000759951
resolver
ensp
ENSP00000759952
resolver
genesymbol
EDA2R
resolver
genesymbol_syn
TNFRSF27
resolver
genesymbol_syn
XEDAR
resolver
hgnc
HGNC:17756
resolver
uniprot
B2RBZ9
resolver
uniprot
B4DQY6
resolver
uniprot
Q5VYX9
resolver
uniprot
Q5VYY0
resolver
uniprot
Q6UWM2
resolver
uniprot
Q8IZA6
resolver
uniprot_entry
B2RBZ9_HUMAN
resolver
uniprot_entry
B4DQY6_HUMAN
resolver
uniprot_entry
TNR27_HUMAN
resolver
uniprot_sec
Q5VYX9
resolver
uniprot_sec
Q5VYY0
resolver
uniprot_sec
Q6UWM2
resolver
uniprot_sec
Q8IZA6
resolver
amino_acid_sequence
MDCQENEYWDQWGRCVTCQRCGPGQELSKDCGYGEGGDAYCTACPPRRYKSSWGHHRCQSCITCAVINRVQKVNCTATSNAVCGDCLPRFYRKTRIGGLQDQECIPCTKQTPTSEVQCAFQLSLVEADTPTVPPQEATLVALVSSLLVVFTLAFLGLFFLYCKQFFNRHCQRGGLLQFEADKTAKEESLFPVPPSKETSAESQVSENIFQTQPLNPILEDDCSSTSGFPTQESFTMASCTSESHSHWVHSPIECTELDLQKFSSSASYTGAETLGGNTVESTGDRLELNVPFEVPSP
uniprot
proteins
function
FUNCTION: Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6. {ECO:0000269|PubMed:12270937}.
uniprot
proteins
mass_dalton
32759
uniprot
proteins
mutagenesis
MUTAGEN 256; /note="E->R: Abolishes TRAF6 association."; /evidence="ECO:0000269|PubMed:11039935
uniprot
proteins
pubmed
11039935
uniprot
proteins
pubmed
12270937
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
sequence_length
297
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type III membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 139..159; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins