Cacng3
entrez
54376
canonical
uniprot
Q9JJV5
canonical
ensembl
ENSMUSG00000066189
resolver
ensp
ENSMUSP00000081664
resolver
enst
ENSMUST00000084615
resolver
genesymbol
Cacng3
resolver
uniprot
A6H6R5
resolver
uniprot_entry
CCG3_MOUSE
resolver
uniprot_sec
A6H6R5
resolver
amino_acid_sequence
MRMCDRGIQMLITTVGAFAAFSLMTIAVGTDYWLYSRGVCRTKSTSDNETSRKNEEVMTHSGLWRTCCLEGAFRGVCKKIDHFPEDADYEQDTAEYLLRAVRASSVFPILSVTLLFFGGLCVAASEFHRSRHSVILSAGIFFVSAGLSNIIGIIVYISANAGDPGQRDSKKSYSYGWSFYFGAFSFIIAEIVGVVAVHIYIEKHQQLRARSHSELLKKSTFARLPPYRYRFRRRSSSRSTEPRSRDLSPISKGFHTIPSTDISMFTLSRDPSKLTMGTLLNSDRDHAFLQFHNSTPKEFKESLHNNPANRRTTPV
uniprot
proteins
function
FUNCTION: Regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs) (PubMed:18341993). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state (By similarity). {ECO:0000250|UniProtKB:Q8VHX0, ECO:0000269|PubMed:18341993}.
uniprot
proteins
mass_dalton
35516
uniprot
proteins
mutagenesis
MUTAGEN 227..240; /note="YRYRFRRRSSSRST->ARARARRRAAARAA: Decreased interaction with AP4M1. Has no effect on interaction with GRIA1. Dominant negative mutant which alters AMPARs localization to the somatodendritic compartment."; /evidence="ECO:0000269|PubMed:18341993
uniprot
proteins
protein_family
CACNG subfamily
uniprot
proteins
protein_family
PMP-22/EMP/MP20 family
uniprot
proteins
pubmed
10734232
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18341993
uniprot
proteins
sequence_length
315
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Note=Displays a somatodendritic localization and is excluded from axons in neurons. {ECO:0000269|PubMed:18341993}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 104..124; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 135..155; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 181..201; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins