Rap1a
entrez
109905
canonical
uniprot
P62835
canonical
ensembl
ENSMUSG00000068798
resolver
ensp
ENSMUSP00000088174
resolver
ensp
ENSMUSP00000308133
resolver
ensp
ENSMUSP00000308135
resolver
ensp
ENSMUSP00000361009
resolver
enst
ENSMUST00000090678
resolver
genesymbol
Rap1a
resolver
genesymbol_syn
Krev-1
resolver
uniprot
P10113
resolver
uniprot
Q3U7U8
resolver
uniprot
Q3V3W9
resolver
uniprot_entry
Q3U7U8_MOUSE
resolver
uniprot_entry
Q3V3W9_MOUSE
resolver
uniprot_entry
RAP1A_MOUSE
resolver
uniprot_sec
P10113
resolver
activity_regulation
ACTIVITY REGULATION: Activated by guanine nucleotide-exchange factors (GEF) EPAC and EPAC2 in a cAMP-dependent manner, and GFR. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MREYKLVVLGSGGVGKSALTVQFVQGIFVEKYDPTIEDSYRKQVEVDCQQCMLEILDTAGTEQFTAMRDLYMKNGQGFALVYSITAQSTFNDLQDLREQILRVKDTEDVPMILVGNKCDLEDERVVGKEQGQNLARQWCNCAFLESSAKSKINVNEIFYDLVRQINRKTPVEKKKPKKKSCLLL
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Counteracts the mitogenic function of Ras, at least partly because it can interact with Ras GAPs and RAF in a competitive manner. Together with ITGB1BP1, regulates KRIT1 localization to microtubules and membranes (By similarity). Plays a role in nerve growth factor (NGF)-induced neurite outgrowth. Plays a role in the regulation of embryonic blood vessel formation. Involved in the establishment of basal endothelial barrier function. Facilitates the progressive accumulation of CDH1 at mature desmosome junctions via cAMP-dependent signaling and its interaction with PKP3 (By similarity). May be involved in the regulation of the vascular endothelial growth factor receptor KDR expression at endothelial cell-cell junctions. {ECO:0000250|UniProtKB:P62834, ECO:0000269|PubMed:19635461}.
uniprot
proteins
mass_dalton
20987
uniprot
proteins
protein_family
Ras family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19635461
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30360518
uniprot
proteins
sequence_length
184
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cell junction {ECO:0000269|PubMed:19635461}. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Early endosome {ECO:0000250}. Late endosome {ECO:0000250}. Note=Recruited from early endosome to late endosome compartment after nerve growth factor (NGF) stimulation. Colocalized with RAPGEF2 in the perinuclear region (By similarity). Localized with RAPGEF2 at cell-cell junctions. {ECO:0000250}.
uniprot
proteins