EIF4B
entrez
1975
canonical
uniprot
P23588
canonical
ensembl
ENSG00000063046
resolver
ensp
ENSP00000262056
resolver
ensp
ENSP00000388806
resolver
ensp
ENSP00000412530
resolver
enst
ENST00000420463
resolver
genesymbol
EIF4B
resolver
hgnc
HGNC:3285
resolver
uniprot
B4DRM3
resolver
uniprot
B4DS13
resolver
uniprot
E7EX17
resolver
uniprot
Q4G0E3
resolver
uniprot
Q53HQ2
resolver
uniprot
Q6GPH5
resolver
uniprot
Q6IB46
resolver
uniprot
Q7Z5Y0
resolver
uniprot
Q8WYK5
resolver
uniprot_entry
B4DRM3_HUMAN
resolver
uniprot_entry
E7EX17_HUMAN
resolver
uniprot_entry
IF4B_HUMAN
resolver
uniprot_entry
Q7Z5Y0_HUMAN
resolver
uniprot_sec
B4DS13
resolver
uniprot_sec
Q4G0E3
resolver
uniprot_sec
Q53HQ2
resolver
uniprot_sec
Q6GPH5
resolver
uniprot_sec
Q6IB46
resolver
uniprot_sec
Q8WYK5
resolver
amino_acid_sequence
MAASAKKKNKKGKTISLTDFLAEDGGTGGGSTYVSKPVSWADETDDLEGDVSTTWHSNDDDVYRAPPIDRSILPTAPRAAREPNIDRSRLPKSPPYTAFLGNLPYDVTEESIKEFFRGLNISAVRLPREPSNPERLKGFGYAEFEDLDSLLSALSLNEESLGNRRIRVDVADQAQDKDRDDRSFGRDRNRDSDKTDTDWRARPATDSFDDYPPRRGDDSFGDKYRDRYDSDRYRDGYRDGYRDGPRRDMDRYGGRDRYDDRGSRDYDRGYDSRIGSGRRAFGSGYRRDDDYRGGGDRYEDRYDRRDDRSWSSRDDYSRDDYRRDDRGPPQRPKLNLKPRSTPKEDDSSASTSQSTRAASIFGGAKPVDTAAREREVEERLQKEQEKLQRQLDEPKLERRPRERHPSWRSEETQERERSRTGSESSQTGTSTTSSRNARRRESEKSLENETLNKEEDCHSPTSKPPKPDQPLKVMPAPPPKENAWVKRSSNPPARSQSSDTEQQSPTSGGGKVAPAQPSEEGPGRKDENKVDGMNAPKGQTGNSSRGPGDGGNRDHWKESDRKDGKKDQDSRSAPEPKKPEENPASKFSSASKYAALSVDGEDENEGEDYAE
uniprot
proteins
function
FUNCTION: Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
uniprot
proteins
mass_dalton
69151
uniprot
proteins
mutagenesis
MUTAGEN 406; /note="S->A: Non-phosphorylatable mutant whose expression results in reduced SLC4A7 protein levels in TSC2-deficient cells accompanied by decrease in the bicarbonate-dependent flux into nucleotide synthesis."; /evidence="ECO:0000269|PubMed:35772404"; MUTAGEN 422; /note="S->A: Non-phosphorylatable mutant whose expression results in reduced SLC4A7 protein levels in TSC2-deficient cells accompanied by decrease in the bicarbonate-dependent flux into nucleotide synthesis."; /evidence="ECO:0000269|PubMed:35772404
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-422 by RPS6KA1 and RPS6KB1; phosphorylation enhances the affinity of EIF4B for the EIF3 complex. In response to mTORC1 activation, RPS6KA1-mediated phosphorylation at 'Ser-406' and 'Ser-422' stimulates bicarbonate cotransporter SLC4A7 mRNA translation, increasing SLC4A7 protein abundance and function. {ECO:0000269|PubMed:15071500, ECO:0000269|PubMed:16763566}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15071500
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
16763566
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21248752
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2390971
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
35772404
uniprot
proteins
pubmed
8139536
uniprot
proteins
pubmed
8816444
uniprot
proteins
sequence_length
611
uniprot
proteins