Med23
entrez
70208
canonical
uniprot
Q80YQ2
canonical
ensembl
ENSMUSG00000019984
resolver
ensp
ENSMUSP00000020159
resolver
ensp
ENSMUSP00000090316
resolver
enst
ENSMUST00000020159
resolver
enst
ENSMUST00000092646
resolver
genesymbol
Med23
resolver
genesymbol_syn
Crsp3
resolver
genesymbol_syn
Kiaa1216
resolver
genesymbol_syn
Sur2
resolver
uniprot
E9QNV2
resolver
uniprot
F8WJB0
resolver
uniprot
Q6ZPV7
resolver
uniprot
Q8CEC3
resolver
uniprot
Q8K587
resolver
uniprot
Q9CXY8
resolver
uniprot_entry
E9QNV2_MOUSE
resolver
uniprot_entry
F8WJB0_MOUSE
resolver
uniprot_entry
MED23_MOUSE
resolver
uniprot_sec
Q6ZPV7
resolver
uniprot_sec
Q8CEC3
resolver
uniprot_sec
Q8K587
resolver
uniprot_sec
Q9CXY8
resolver
amino_acid_sequence
METQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLAAFRQFWSGLSQESHEQCVQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCESLINSDSLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKAILEKILTIPNTVSSAVVQQLLAAREVIAYILERNACLLPAYFAVTEIRKLYPEGKLPHWLLGNLVSDFVDTFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKDLFEPQTALLRYVLEQPYSRDMVCNMLGLNKQHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDINKPQSTHAFAMTCIWIHLNRKAQNGDSTLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRVPLPGTSCLASASVTPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHTKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSHRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLNDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMNFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTDENEIITQFSVQGFPPLFLCLLWKMLLETDHISQIGYKVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQSDWHTKHMSYHKKYPEKLYFEGLAEQVDPPVPIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYEMCLRNRDHLKRKLVHAIIGSLKDNRPQGWCLSDTYLKHAMNAREDNPWVPEDSYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKDVGNALLNVVLKSQPLVPRENITAWMNAIGLIITALPEPYWIVLHDRIVNVISSSSLTSETEWVGYPFRLFDFTACHQSYSEMSCSYTLALAHAVWHHSSIGQLSLIPKFLTEALLPVVKTEFQLLYVYHLVGPFLQRFQQERTRCMIEIGVAFYDMLLNVDQCSTHLNYMDPICDFLYHMKYMFTGDSVKEQVEKIICNLKPALKLRLRFITHISKMEPAVPPQALNSGSPAPQSNQVPASLPVTQ
uniprot
proteins
function
FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity). Also required for transcriptional activation subsequent to the assembly of the pre-initiation complex. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. {ECO:0000250, ECO:0000269|PubMed:11934987, ECO:0000269|PubMed:14759369, ECO:0000269|PubMed:15542641, ECO:0000269|PubMed:15749018}.
uniprot
proteins
mass_dalton
156087
uniprot
proteins
protein_family
Mediator complex subunit 23 family
uniprot
proteins
pubmed
11934987
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
14759369
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15542641
uniprot
proteins
pubmed
15749018
uniprot
proteins
pubmed
16137621
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20111005
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1367
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins