Itpa
entrez
311422
canonical
uniprot
D3ZW55
canonical
ensembl
ENSRNOG00000021233
resolver
ensp
ENSRNOP00000028838
resolver
genesymbol
Itpa
resolver
uniprot_entry
ITPA_RAT
resolver
amino_acid_sequence
MAASLVGKKIVFVTGNAKKLEEVIQILGDKFPCTLVAQKIDLPEYQGEPDEISIQKCQEAARQVQGPVLVEDTCLCFNALGGLPGPYIKWFLQKLKPEGLYQLLAGFEDKSAYALCTFALSTGDPSQPVLLFRGKTPGQIVMPRGSRDFGWDPCFQPDGYEQTYAEMPKAEKNTISHRFRALFKLQEYFGVTDGAGDH
uniprot
proteins
ec_number
3.6.1.66
uniprot
proteins
function
FUNCTION: Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. {ECO:0000255|HAMAP-Rule:MF_03148}.
uniprot
proteins
mass_dalton
21927
uniprot
proteins
protein_family
HAM1 NTPase family
uniprot
proteins
sequence_length
198
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03148}.
uniprot
proteins