ANTKMT
entrez
65990
canonical
uniprot
Q9BQD7
canonical
ensembl
ENSG00000103254
resolver
ensp
ENSP00000219535
resolver
ensp
ENSP00000454380
resolver
enst
ENST00000219535
resolver
enst
ENST00000569529
resolver
genesymbol
ANTKMT
resolver
genesymbol_syn
C16orf24
resolver
genesymbol_syn
FAM173A
resolver
hgnc
HGNC:14152
resolver
uniprot
A2IDD4
resolver
uniprot
J3KMW5
resolver
uniprot_entry
ANKMT_HUMAN
resolver
uniprot_entry
J3KMW5_HUMAN
resolver
uniprot_sec
A2IDD4
resolver
amino_acid_sequence
MEQDDPVEALTELRERRLGALELLQAAAGSGLAAYAVWALLLQPGFRRVPLRLQVPYVGASARQVEHVLSLLRGRPGKTVDLGSGDGRIVLAAHRCGLRPAVGYELNPWLVALARLHAWRAGCAGSVCYRRKDLWKVSLRDCRNVSVFLAPSVLPLLEDKLRTELPAGARVVSGRFPLPTWQPVTAVGEGLDRVWAYDVPEGGQAGEAASSRIPIQAAPGPSSAPIPGGLISQAS
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Mitochondrial protein-lysine N-methyltransferase that trimethylates adenine nucleotide translocases ANT2/SLC25A5 and ANT3/SLC25A6, thereby regulating mitochondrial respiration (PubMed:31213526). Probably also trimethylates ANT1/SLC25A4 (PubMed:31213526). {ECO:0000269|PubMed:31213526}.
uniprot
proteins
mass_dalton
25130
uniprot
proteins
mutagenesis
MUTAGEN 1..76; /note="Missing: Abolished mitochondrial localization."; /evidence="ECO:0000269|PubMed:31213526"; MUTAGEN 1..42; /note="Missing: Does not affect mitochondrial localization."; /evidence="ECO:0000269|PubMed:31213526"; MUTAGEN 105; /note="E->A: Abolished methyltransferase activity."; /evidence="ECO:0000269|PubMed:31213526
uniprot
proteins
protein_family
ANT/ATPSC lysine N-methyltransferase family
uniprot
proteins
pubmed
11157797
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
31213526
uniprot
proteins
sequence_length
235
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:31213526}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 20..42; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins