Mmut
entrez
17850
canonical
uniprot
P16332
canonical
ensembl
ENSMUSG00000023921
resolver
ensp
ENSMUSP00000130941
resolver
enst
ENSMUST00000169611
resolver
genesymbol
Mmut
resolver
genesymbol_syn
Mut
resolver
uniprot
Q3UJU1
resolver
uniprot
Q9CSI4
resolver
uniprot_entry
MUTA_MOUSE
resolver
uniprot_entry
Q9CSI4_MOUSE
resolver
uniprot_sec
Q3UJU1
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by itaconyl-CoA, a metabolite that inactivates the coenzyme B12 cofactor. Inhibited by malyl-coA. {ECO:0000250|UniProtKB:P22033}.
uniprot
proteins
amino_acid_sequence
MLRAKNQLFLLSPHYLKQLNIPSASRWKRLLHQQQPLHPEWAVLAKKQLKGKNPEDLIWHTPEGISIKPLYSRADTLDLPEELPGVKPFTRGPYPTMYTYRPWTIRQYAGFSTVEESNKFYKDNIKAGQQGLSVAFDLATHRGYDSDNPRVRGDVGMAGVAIDTVEDTKILFDGIPLEKMSVSMTMNGAVIPVLATFIVTGEEQGVPKEKLTGTIQNDILKEFMVRNTYIFPPEPSMKIIADIFQYTAQHMPKFNSISISGYHMQEAGADAILELAYTIADGLEYCRTGLQAGLTIDEFAPRLSFFWGIGMNFYMEIAKMRAGRRLWAHLIEKMFQPKNSKSLLLRAHCQTSGWSLTEQDPYNNIVRTAIEAMAAVFGGTQSLHTNSFDEALGLPTVKSARIARNTQIIIQEESGIPKVADPWGGSYMMESLTNDVYEAALKLIYEVEEMGGMAKAVAEGIPKLRIEECAARRQARIDSGSEVIVGVNKYQLEKEDSVEVLAIDNTSVRKKQIEKLKKIKSSRDQALAEQCLSALTQCAASGDGNILALAVDAARARCTVGEITDALKKVFGEHKANDRMVSGAYRQEFGESKEITSAIKRVNKFMEREGRRPRLLVAKMGQDGHDRGAKVIATGFADLGFDVDIGPLFQTPREVAQQAVDADVHAVGVSTLAAGHKTLVPELIKELTALGRPDILVMCGGVIPPQDYEFLYEVGVSNVFGPGTRIPRAAVQVLDDIEKCLAEKQQSV
uniprot
proteins
ec_number
5.4.99.2
uniprot
proteins
function
FUNCTION: Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle. {ECO:0000269|PubMed:1978672}.
uniprot
proteins
mass_dalton
82844
uniprot
proteins
protein_family
Methylmalonyl-CoA mutase family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1978672
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
748
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:P22033}. Mitochondrion {ECO:0000250|UniProtKB:P22033}. Cytoplasm {ECO:0000250|UniProtKB:P22033}.
uniprot
proteins