Pdzk1
entrez
59020
canonical
uniprot
Q9JIL4
canonical
ensembl
ENSMUSG00000038298
resolver
ensp
ENSMUSP00000058936
resolver
ensp
ENSMUSP00000102684
resolver
ensp
ENSMUSP00000102685
resolver
ensp
ENSMUSP00000118846
resolver
ensp
ENSMUSP00000174905
resolver
enst
ENSMUST00000058865
resolver
enst
ENSMUST00000107069
resolver
enst
ENSMUST00000107070
resolver
enst
ENSMUST00000153256
resolver
genesymbol
Pdzk1
resolver
genesymbol_syn
Cap70
resolver
genesymbol_syn
Nherf3
resolver
uniprot
A0A0R4J1V0
resolver
uniprot
Q8CDP5
resolver
uniprot
Q8R4G2
resolver
uniprot
Q9CQ72
resolver
uniprot_entry
A0A0R4J1V0_MOUSE
resolver
uniprot_entry
NHRF3_MOUSE
resolver
uniprot_sec
Q8CDP5
resolver
uniprot_sec
Q8R4G2
resolver
uniprot_sec
Q9CQ72
resolver
amino_acid_sequence
MASTFNPRECKLSKQEGQNYGFFLRIEKDTDGHLIRVIEEGSPAEKAGLLDGDRVLRINGVFVDKEEHAQVVELVRKSGNSVTLLVLDGDSYEKAVKNQVDLKELDQSQREAALNDKKPGPGMNGAVEPCAQPRLCYLVKEGNSFGFSLKTIQGKKGVYLTDIMPQGVAMKAGVLADDHLIEVNGENVENASHEEVVEKVTKSGSRIMFLLVDKETARCHSEQKTQFKRETASLKLLPHQPRVVVIKKGSNGYGFYLRAGPEQKGQIIKDIEPGSPAEAAGLKNNDLVVAVNGKSVEALDHDGVVEMIRKGGDQTTLLVLDKEAESIYSLARFSPLLYCQSQELPNGSVKEGPAPIPAPLEATGSEPTEDAEGHKPKLCRLLKEDDSYGFHLNAIRGQPGSFVKEVQQGGPADKAGLENEDVIIEVNGENVQEEPYDRVVERIKSSGKHVTLLVCGKMAYSYFQAKKIPIVSSMAEPLVAGPDEKGETSAESEHDAHPAKDRTLSTASHSSSNSEDTEM
uniprot
proteins
function
FUNCTION: A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with NHERF1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity (By similarity). Required for normal cell-surface expression of SCARB1. Plays a role in maintaining normal plasma cholesterol levels via its effects on SCARB1. Plays a role in the normal localization and function of the chloride-anion exchanger SLC26A6 to the plasma membrane in the brush border of the proximal tubule of the kidney. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function. {ECO:0000250, ECO:0000269|PubMed:11051556, ECO:0000269|PubMed:12556478, ECO:0000269|PubMed:14531806, ECO:0000269|PubMed:15523054, ECO:0000269|PubMed:16141316, ECO:0000269|PubMed:20739281, ECO:0000269|PubMed:21602281}.
uniprot
proteins
mass_dalton
56499
uniprot
proteins
mutagenesis
MUTAGEN 14; /note="K->A: Impairs interaction of the first PDZ domain with SCARB1."; /evidence="ECO:0000269|PubMed:20739281"; MUTAGEN 20; /note="Y->A: Disrupts interaction of the first PDZ domain with SCARB1. Abolishes interaction with SCARB1; when associated with A-253."; /evidence="ECO:0000269|PubMed:20739281, ECO:0000269|PubMed:21602281"; MUTAGEN 253; /note="Y->A: Disrupts interaction of the third PDZ domain with SCARB1. Abolishes interaction with SCARB1; when associated with A-20."; /evidence="ECO:0000269|PubMed:21602281
uniprot
proteins
protein_family
NHER family
uniprot
proteins
pubmed
11051556
uniprot
proteins
pubmed
11099500
uniprot
proteins
pubmed
12556478
uniprot
proteins
pubmed
14531806
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15523054
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16141316
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
20739281
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21602281
uniprot
proteins
pubmed
23457445
uniprot
proteins
sequence_length
519
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9JJ40}. Cell membrane {ECO:0000269|PubMed:11051556, ECO:0000269|PubMed:16141316}. Note=Localized in the brush border membrane of renal proximal tubule cells (PubMed:11051556, PubMed:16141316). Associated with peripheral membranes (By similarity). Localizes to the apical compartment of proximal cells and to sinusoidal liver membranes (By similarity). {ECO:0000250|UniProtKB:Q9JJ40, ECO:0000269|PubMed:11051556, ECO:0000269|PubMed:16141316}.
uniprot
proteins