SLC6A18
entrez
348932
canonical
uniprot
Q96N87
canonical
ensembl
ENSG00000164363
resolver
ensp
ENSP00000323549
resolver
enst
ENST00000324642
resolver
genesymbol
SLC6A18
resolver
genesymbol_syn
B0AT3
resolver
genesymbol_syn
XTRP2
resolver
hgnc
HGNC:26441
resolver
uniprot_entry
S6A18_HUMAN
resolver
amino_acid_sequence
MAHAPEPDPAACDLGDERPKWDNKAQYLLSCTGFAVGLGNIWRFPYLCQTYGGGAFLIPYVIALVFEGIPIFHVELAIGQRLRKGSVGVWTAISPYLSGVGLGCVTLSFLISLYYNTIVAWVLWYLLNSFQHPLPWSSCPPDLNRTGFVEECQGSSAVSYFWYRQTLNITADINDSGSIQWWLLICLAASWAVVYMCVIRGIETTGKVIYFTALFPYLVLTIFLIRGLTLPGATKGLIYLFTPNMHILQNPRVWLDAATQIFFSLSLAFGGHIAFASYNSPRNDCQKDAVVIALVNRMTSLYASIAVFSVLGFKATNDYEHCLDRNILSLINDFDFPEQSISRDDYPAVLMHLNATWPKRVAQLPLKACLLEDFLDKSASGPGLAFVVFTETDLHMPGAPVWAMLFFGMLFTLGLSTMFGTVEAVITPLLDVGVLPRWVPKEALTGLVCLVCFLSATCFTLQSGNYWLEIFDNFAASPNLLMLAFLEVVGVVYVYGMKRFCDDIAWMTGRRPSPYWRLTWRVVSPLLLTIFVAYIILLFWKPLRYKAWNPKYELFPSRQEKLYPGWARAACVLLSLLPVLWVPVAALAQLLTRRRRTWRDRDARPDTDMRPDTDTRPDTDMRPDTDMR
uniprot
proteins
disease_involvement
DISEASE: Note=Genetic variations in SLC6A18 might contribute to the disease phentotype in some individuals with iminoglycinuria or hyperglycinuria, that carry variants in SLC36A2, SLC6A19 or SLC6A20 (PubMed:19033659). {ECO:0000269|PubMed:19033659}.
uniprot
proteins
function
FUNCTION: Does not show neutral amino acid transporter activity. {ECO:0000269|PubMed:26240152}.
uniprot
proteins
mass_dalton
70897
uniprot
proteins
protein_family
SLC6A18 subfamily
uniprot
proteins
protein_family
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15286787
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16340170
uniprot
proteins
pubmed
19033659
uniprot
proteins
pubmed
26240152
uniprot
proteins
sequence_length
628
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 27..47; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 52..74; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 89..111; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 179..201; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 208..230; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 254..276; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 289..311; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 400..422; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 443..465; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 475..497; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 518..540; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 569..591; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins