Jkamp
entrez
104771
canonical
uniprot
Q8BI36
canonical
ensembl
ENSMUSG00000005078
resolver
ensp
ENSMUSP00000061370
resolver
ensp
ENSMUSP00000113744
resolver
genesymbol
Jkamp
resolver
genesymbol_syn
Jamp
resolver
uniprot
B8JJ79
resolver
uniprot
B8JJ80
resolver
uniprot
Q99LT2
resolver
uniprot
Q9CUZ1
resolver
uniprot_entry
JKAMP_MOUSE
resolver
uniprot_sec
B8JJ79
resolver
uniprot_sec
B8JJ80
resolver
uniprot_sec
Q99LT2
resolver
uniprot_sec
Q9CUZ1
resolver
amino_acid_sequence
MAVDIQPACLGLYCGKTLLFKNGSSEIYGECGVCPRGQRTNAQKYCQPCTESPELYDWLYLGFMAMLPLVLHWFFIEWYSGKKSSSALFQHITALFECTMAAIITLLVSDPVGVLYIRSCRVLMLSDWYTMLYNPSPDYVTTVHCTHEAVYPLYTIVFVYYAFCLVLMMLLRPLLVKKIACGLGKSDRFKSIYAALYFFPILTVLQAVGGGLLYYAFPYIILVLSLVTLAVYMSASEIENCYDLLVRKKRLIVLFSHWLLHAYGIVSISRVDRLEHDLPLLALVPTPALFYLFTAKFTEPSRILSEGANGH
uniprot
proteins
function
FUNCTION: Regulates the duration of MAPK8 activity in response to various stress stimuli (PubMed:16166642). Facilitates the degradation of misfolded endoplasmic reticulum (ER) proteins through the recruitment of components of the proteasome and endoplasmic reticulum-associated degradation (ERAD) system (PubMed:18784250). Is required for proper degradation of prosaposin receptor GPR37 (By similarity). {ECO:0000250|UniProtKB:Q9P055, ECO:0000269|PubMed:16166642, ECO:0000269|PubMed:18784250}.
uniprot
proteins
mass_dalton
35248
uniprot
proteins
mutagenesis
MUTAGEN 24; /note="S->A: Loss of glycosylation."; /evidence="ECO:0000269|PubMed:16166642
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by RNF5 via 'Lys-63'-linked ubiquitin linkage in a UBE2N-dependent manner. Ubiquitination decreases association with components of the proteasome and ERAD. {ECO:0000269|PubMed:19269966}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16166642
uniprot
proteins
pubmed
18784250
uniprot
proteins
pubmed
19269966
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
311
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16166642, ECO:0000269|PubMed:18784250}; Multi-pass membrane protein {ECO:0000269|PubMed:16166642, ECO:0000269|PubMed:18784250}.
uniprot
proteins
transmembrane_region
TRANSMEM 58..78; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 88..108; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 150..170; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 189..209; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 211..231; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 251..271; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 278..298; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins