LILRA3
entrez
11026
canonical
uniprot
Q8N6C8
canonical
ensembl
ENSG00000273884
resolver
ensembl
ENSG00000275841
resolver
ensembl
ENSG00000276175
resolver
ensembl
ENSG00000278046
resolver
genesymbol
LILRA3
resolver
genesymbol_syn
ILT6
resolver
genesymbol_syn
LIR4
resolver
hgnc
HGNC:6604
resolver
uniprot
J3KPM2
resolver
uniprot
O15469
resolver
uniprot
O15470
resolver
uniprot
O75016
resolver
uniprot
Q8N151
resolver
uniprot
Q8N154
resolver
uniprot
Q8NHJ1
resolver
uniprot
Q8NHJ2
resolver
uniprot
Q8NHJ3
resolver
uniprot
Q8NHJ4
resolver
uniprot_entry
LIRA3_HUMAN
resolver
uniprot_sec
J3KPM2
resolver
uniprot_sec
O15469
resolver
uniprot_sec
O15470
resolver
uniprot_sec
O75016
resolver
uniprot_sec
Q8N151
resolver
uniprot_sec
Q8N154
resolver
uniprot_sec
Q8NHJ1
resolver
uniprot_sec
Q8NHJ2
resolver
uniprot_sec
Q8NHJ3
resolver
uniprot_sec
Q8NHJ4
resolver
amino_acid_sequence
MTPILTVLICLGLSLDPRTHVQAGPLPKPTLWAEPGSVITQGSPVTLRCQGSLETQEYHLYREKKTALWITRIPQELVKKGQFPILSITWEHAGRYCCIYGSHTAGLSESSDPLELVVTGAYSKPTLSALPSPVVTSGGNVTIQCDSQVAFDGFILCKEGEDEHPQCLNSHSHARGSSRAIFSVGPVSPSRRWSYRCYGYDSRAPYVWSLPSDLLGLLVPGVSKKPSLSVQPGPVVAPGEKLTFQCGSDAGYDRFVLYKEWGRDFLQRPGRQPQAGLSQANFTLGPVSRSYGGQYTCSGAYNLSSEWSAPSDPLDILITGQIRARPFLSVRPGPTVASGENVTLLCQSQGGMHTFLLTKEGAADSPLRLKSKRQSHKYQAEFPMSPVTSAHAGTYRCYGSLSSNPYLLTHPSDPLELVVSGAAETLSPPQNKSDSKAGE
uniprot
proteins
function
FUNCTION: Acts as a soluble receptor for class I MHC antigens. Binds both classical and non-classical HLA class I molecules but with reduced affinities compared to LILRB1 or LILRB2. Binds with high affinity to the surface of monocytes, leading to abolish LPS-induced TNF production by monocytes. {ECO:0000269|PubMed:21559424, ECO:0000269|PubMed:24085305}.
uniprot
proteins
mass_dalton
47472
uniprot
proteins
post_translational_modification
PTM: N-glycosylation is required for ligand binding. {ECO:0000269|PubMed:24085305}.
uniprot
proteins
pubmed
12750859
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21559424
uniprot
proteins
pubmed
24085305
uniprot
proteins
pubmed
9079806
uniprot
proteins
pubmed
9278324
uniprot
proteins
pubmed
9548455
uniprot
proteins
sequence_length
439
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
uniprot
proteins