DYNC1I1
entrez
1780
canonical
uniprot
O14576
canonical
ensembl
ENSG00000158560
resolver
ensp
ENSP00000320130
resolver
ensp
ENSP00000352348
resolver
ensp
ENSP00000392337
resolver
ensp
ENSP00000398118
resolver
ensp
ENSP00000486363
resolver
genesymbol
DYNC1I1
resolver
genesymbol_syn
DNCI1
resolver
genesymbol_syn
DNCIC1
resolver
hgnc
HGNC:2963
resolver
uniprot
A4D1I7
resolver
uniprot
B4DME3
resolver
uniprot
F5H050
resolver
uniprot
G5E9K1
resolver
uniprot
Q8N542
resolver
uniprot
Q8TBF7
resolver
uniprot
Q9Y2X1
resolver
uniprot_entry
A4D1I7_HUMAN
resolver
uniprot_entry
DC1I1_HUMAN
resolver
uniprot_entry
Q8N542_HUMAN
resolver
uniprot_sec
B4DME3
resolver
uniprot_sec
F5H050
resolver
uniprot_sec
G5E9K1
resolver
uniprot_sec
Q8TBF7
resolver
uniprot_sec
Q9Y2X1
resolver
amino_acid_sequence
MSDKSDLKAELERKKQRLAQIREEKKRKEEERKKKEADMQQKKEPVQDDSDLDRKRRETEALLQSIGISPEPPLVQPLHFLTWDTCYFHYLVPTPMSPSSKSVSTPSEAGSQDSGDLGPLTRTLQWDTDPSVLQLQSDSELGRRLHKLGVSKVTQVDFLPREVVSYSKETQTPLATHQSEEDEEDEEMVESKVGQDSELENQDKKQEVKEAPPRELTEEEKQQILHSEEFLIFFDRTIRVIERALAEDSDIFFDYSGRELEEKDGDVQAGANLSFNRQFYDEHWSKHRVVTCMDWSLQYPELMVASYNNNEDAPHEPDGVALVWNMKFKKTTPEYVFHCQSSVMSVCFARFHPNLVVGGTYSGQIVLWDNRSHRRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLITVSTDGKMCSWSLDMLSTPQESMELVYNKSKPVAVTGMAFPTGDVNNFVVGSEEGTVYTACRHGSKAGIGEVFEGHQGPVTGINCHMAVGPIDFSHLFVTSSFDWTVKLWTTKHNKPLYSFEDNADYVYDVMWSPVHPALFACVDGMGRLDLWNLNNDTEVPTASVAIEGASALNRVRWAQAGKEVAVGDSEGRIWVYDVGELAVPHNDEWTRFARTLVEIRANRADSEEEGTVELSA
uniprot
proteins
function
FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.
uniprot
proteins
mass_dalton
72955
uniprot
proteins
mutagenesis
MUTAGEN 148; /note="L->G: Disrupts interaction with DYNLT1."; /evidence="ECO:0000269|PubMed:27502274"; MUTAGEN 149; /note="G->E: No effect on interaction with DYNLT1."; /evidence="ECO:0000269|PubMed:27502274"; MUTAGEN 150; /note="V->G: Disrupts interaction with DYNLT1."; /evidence="ECO:0000269|PubMed:27502274"; MUTAGEN 150; /note="V->W: No effect on interaction with DYNLT1."; /evidence="ECO:0000269|PubMed:27502274"; MUTAGEN 152; /note="K->A,Y: No effect on interaction with DYNLT1."; /evidence="ECO:0000269|PubMed:27502274"; MUTAGEN 153; /note="V->G: Decreases interaction with DYNLT1."; /evidence="ECO:0000269|PubMed:27502274"; MUTAGEN 155; /note="Q->H,R,T,Y: No effect on interaction with DYNLT1."; /evidence="ECO:0000269|PubMed:27502274"; MUTAGEN 156; /note="V->G: Decreases interaction with DYNLT1."; /evidence="ECO:0000269|PubMed:27502274"; MUTAGEN 157; /note="D->R: No effect on interaction with DYNLT1."; /evidence="ECO:0000269|PubMed:27502274"; MUTAGEN 158; /note="F->G: Disrupts interaction with DYNLT1."; /evidence="ECO:0000269|PubMed:27502274
uniprot
proteins
protein_family
Dynein intermediate chain family
uniprot
proteins
pubmed
10049579
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19229290
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21248752
uniprot
proteins
pubmed
27263857
uniprot
proteins
pubmed
27502274
uniprot
proteins
sequence_length
645
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:19229290}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:19229290}.
uniprot
proteins