Edf1
entrez
296570
canonical
uniprot
P69736
canonical
genesymbol
Edf1
resolver
uniprot
B0BNJ5
resolver
uniprot_entry
B0BNJ5_RAT
resolver
uniprot_entry
EDF1_RAT
resolver
amino_acid_sequence
MAESDWDTVTVLRKKGPTAAQAKSKQAILAAQRRGEDVETSKKWAAGQNKQHSITKNTAKLDRETEELHHDRVTLEVGKVIQRGRQSKGLTQKDLATKINEKPQVIADYESGRAIPNNQVLGKIERAIGLKLRGKDIGKPIEKGPKAK
uniprot
proteins
function
FUNCTION: Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. Might function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism (By similarity). {ECO:0000250, ECO:0000269|PubMed:12729799}.
uniprot
proteins
mass_dalton
16369
uniprot
proteins
mutagenesis
MUTAGEN 87; /note="S->D: Loss of binding to CALM."; /evidence="ECO:0000269|PubMed:12729799
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250}.
uniprot
proteins
pubmed
12729799
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9795107
uniprot
proteins
sequence_length
148
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Also nuclear upon binding to NR5A1 and treatment of cells with TPA or forskolin (By similarity). Localized mainly in soma and dendritic processes of neurons. {ECO:0000250, ECO:0000269|PubMed:12729799}.
uniprot
proteins