Ngfr
entrez
18053
canonical
uniprot
Q9Z0W1
canonical
ensembl
ENSMUSG00000000120
resolver
ensp
ENSMUSP00000000122
resolver
enst
ENSMUST00000000122
resolver
genesymbol
Ngfr
resolver
genesymbol_syn
Tnfrsf16
resolver
uniprot
Q8CFT3
resolver
uniprot_entry
TNR16_MOUSE
resolver
uniprot_sec
Q8CFT3
resolver
amino_acid_sequence
MRRAGAACSAMDRLRLLLLLLLLLGVSFGGAKETCSTGMYTHSGECCKACNLGEGVAQPCGANQTVCEPCLDSVTFSDVVSATEPCKPCTECLGLQSMSAPCVEADDAVCRCSYGYYQDEETGRCEACSVCGVGSGLVFSCQDKQNTVCEECPEGTYSDEANHVDPCLPCTVCEDTERQLRECTPWADAECEEIPGRWITRSTPPEGSDVTTPSTQEPEAPPERDLIASTVADTVTTVMGSSQPVVTRGTADNLIPVYCSILAAVVVGLVAYIAFKRWNSCKQNKQGANSRPVNQTPPPEGEKLHSDSGISVDSQSLHDQQTHTQTASGQALKGDGNLYSSLPLTKREEVEKLLNGDTWRHLAGELGYQPEHIDSFTHEACPVRALLASWGAQDSATLDALLAALRRIQRADIVESLCSESTATSPV
uniprot
proteins
function
FUNCTION: Low affinity neurotrophin receptor which can bind to mature NGF, BDNF, NTF3, and NTF4 (PubMed:11559852, PubMed:1317267). Forms a heterodimeric receptor with SORCS2 that binds the precursor forms of NGF (proNGF), BDNF (proBDNF) and NTF3 (proNT3) with high affinity, and has much lower affinity for mature NGF and BDNF (PubMed:22155786, PubMed:24908487, PubMed:27457814). Plays an important role in differentiation and survival of specific neuronal populations during development (PubMed:11559852, PubMed:1317267). Can mediate cell survival as well as cell death of neural cells (PubMed:11559852, PubMed:1317267, PubMed:24908487). The heterodimeric receptor formed with SORCS2 plays a role in proBDNF-dependent synaptic plasticity, in hippocampal long term depression (LTD) and long term potentiation (LTP) (PubMed:27457814). Plays a role in the inactivation of RHOA (By similarity). Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (PubMed:22460790). Necessary for the circadian oscillation of the clock genes BMAL1, PER1, PER2 and NR1D1 in the suprachiasmatic nucleus (SCN) of the brain and in liver and of the genes involved in glucose and lipid metabolism in the liver (PubMed:23785138). {ECO:0000250, ECO:0000250|UniProtKB:P08138, ECO:0000269|PubMed:11559852, ECO:0000269|PubMed:1317267, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:22460790, ECO:0000269|PubMed:23785138, ECO:0000269|PubMed:24908487, ECO:0000269|PubMed:27457814}.; FUNCTION: (Microbial infection) Cell surface receptor for rabies virus glycoprotein Gs. {ECO:0000269|PubMed:9857182}.; FUNCTION: [Isoform 2]: Does not bind NGF, BDNF, NTF3, and NTF4. {ECO:0000269|PubMed:11559852}.
uniprot
proteins
mass_dalton
45647
uniprot
proteins
post_translational_modification
PTM: N-glycosylated (PubMed:11559852). O-glycosylated. {ECO:0000250, ECO:0000269|PubMed:11559852}.; PTM: Phosphorylated on serine residues. {ECO:0000250}.
uniprot
proteins
pubmed
11559852
uniprot
proteins
pubmed
11830582
uniprot
proteins
pubmed
1317267
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22155786
uniprot
proteins
pubmed
22460790
uniprot
proteins
pubmed
22923615
uniprot
proteins
pubmed
23785138
uniprot
proteins
pubmed
24908487
uniprot
proteins
pubmed
27457814
uniprot
proteins
pubmed
29909994
uniprot
proteins
pubmed
9857182
uniprot
proteins
sequence_length
427
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11559852, ECO:0000269|PubMed:1317267, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:9857182}; Single-pass type I membrane protein {ECO:0000305}. Cytoplasm {ECO:0000250|UniProtKB:P08138}. Perikaryon {ECO:0000269|PubMed:22155786}. Cell projection, growth cone {ECO:0000269|PubMed:22155786}. Cell projection, dendritic spine {ECO:0000269|PubMed:29909994}.
uniprot
proteins
transmembrane_region
TRANSMEM 255..275; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins