Osm
entrez
18413
canonical
uniprot
P53347
canonical
ensembl
ENSMUSG00000058755
resolver
ensp
ENSMUSP00000074708
resolver
enst
ENSMUST00000075221
resolver
genesymbol
Osm
resolver
uniprot
Q3U1Y5
resolver
uniprot
Q5SPX6
resolver
uniprot_entry
ONCM_MOUSE
resolver
uniprot_sec
Q3U1Y5
resolver
uniprot_sec
Q5SPX6
resolver
amino_acid_sequence
MQTRLLRTLLSLTLSLLILSMALANRGCSNSSSQLLSQLQNQANLTGNTESLLEPYIRLQNLNTPDLRAACTQHSVAFPSEDTLRQLSKPHFLSTVYTTLDRVLYQLDALRQKFLKTPAFPKLDSARHNILGIRNNVFCMARLLNHSLEIPEPTQTDSGASRSTTTPDVFNTKIGSCGFLWGYHRFMGSVGRVFREWDDGSTRSRRQSPLRARRKGTRRIRVRHKGTRRIRVRRKGTRRIWVRRKGSRKIRPSRSTQSPTTRA
uniprot
proteins
function
FUNCTION: Functions as a cytokine that uses only the type II OSM receptor (heterodimers composed of OSMR and IL6ST) (PubMed:9920829). Functionally, regulates many processes including cell proliferation, cell differentiation, cytokine production (PubMed:39532904, PubMed:8605875, PubMed:9920829). Mechanistically, low affinity ligand binding to IL6ST/gp130, induces heterodimerization with OSMR, activating JAK tyrosine kinases (JAK1 or JAK2 and to a lesser extent TYK2) bound to their intracellular domains. These kinases subsequently phosphorylate IL6ST/gp130 and LIFR or OSMR. The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of STAT3 and STAT5B. Moreover, the type II OSM complex receptor recruits SHC1 through OSMR in a JAK1 mediated phosphotyrosine-dependent manner, leading to SHC1 association with GRB2 and downstream activation of the Ras/Raf/MAPK pathway (By similarity). {ECO:0000250|UniProtKB:P13725, ECO:0000269|PubMed:39532904, ECO:0000269|PubMed:8605875, ECO:0000269|PubMed:9920829}.
uniprot
proteins
mass_dalton
30114
uniprot
proteins
post_translational_modification
PTM: Propeptide processing is not important for receptor binding activity but may be important for growth-inhibitory activity. {ECO:0000250|UniProtKB:P13725}.
uniprot
proteins
protein_family
LIF/OSM family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
39532904
uniprot
proteins
pubmed
8605875
uniprot
proteins
pubmed
9584176
uniprot
proteins
pubmed
9920829
uniprot
proteins
sequence_length
263
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P13725}.
uniprot
proteins