Peli1
entrez
67245
canonical
uniprot
Q8C669
canonical
ensembl
ENSMUSG00000020134
resolver
ensp
ENSMUSP00000090979
resolver
ensp
ENSMUSP00000099018
resolver
ensp
ENSMUSP00000239818
resolver
enst
ENSMUST00000093290
resolver
enst
ENSMUST00000101477
resolver
genesymbol
Peli1
resolver
uniprot
Q5SRW7
resolver
uniprot
Q91YL9
resolver
uniprot
Q9CV22
resolver
uniprot
Q9ERJ8
resolver
uniprot_entry
PELI1_MOUSE
resolver
uniprot_entry
Q5SRW7_MOUSE
resolver
uniprot_sec
Q91YL9
resolver
uniprot_sec
Q9CV22
resolver
uniprot_sec
Q9ERJ8
resolver
amino_acid_sequence
MFSPDQENHPSKAPVKYGELIVLGYNGSLPNGDRGRRKSRFALFKRPKANGVKPSTVHIACTPQAAKAISNKDQHSISYTLSRAQTVVVEYTHDSNTDMFQIGRSTESPIDFVVTDTVPGSQSNSDTQSVQSTISRFACRIICERSPPFTARIYAAGFDSSKNIFLGEKAAKWKTSDGQMDGLTTNGVLVMHPRNGFTEDSKPGIWREISVCGNVFSLRETRSAQQRGKMVEIETNQLQDGSLIDLCGATLLWRTAEGLSHTPTVKHLEALRQEINAARPQCPVGFNTLAFPSMKRKDVVDEKQPWVYLNCGHVHGYHNWGNKEERDGKDRECPMCRSVGPYVPLWLGCEAGFYVDAGPPTHAFSPCGHVCSEKTTAYWSQIPLPHGTHTFHAACPFCAHQLAGEQGYIRLIFQGPLD
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:16951688, PubMed:29883609). Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6 (By similarity). Acts as a positive regulator of inflammatory response in microglia through activation of NF-kappa-B and MAP kinase (PubMed:31142803). Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:16951688). Conjugates 'Lys-63'-linked ubiquitin chains to the adapter protein ASC/PYCARD, which in turn is crucial for NLRP3 inflammasome activation (PubMed:34706239). Mediates 'Lys-48'-linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3. Negatively regulates necroptosis by reducing RIPK3 expression. Mediates 'Lys-63'-linked ubiquitination of RIPK1. Following phosphorylation by ATM, catalyzes 'Lys-63'-linked ubiquitination of NBN, promoting DNA repair via homologous recombination. Negatively regulates activation of the metabolic mTORC1 signaling pathway by mediating 'Lys-63'-linked ubiquitination of mTORC1-inhibitory protein TSC1 and thereby promoting TSC1/TSC2 complex stability (PubMed:33215753). {ECO:0000250|UniProtKB:Q96FA3, ECO:0000269|PubMed:16951688, ECO:0000269|PubMed:29883609, ECO:0000269|PubMed:31142803, ECO:0000269|PubMed:33215753, ECO:0000269|PubMed:34706239}.
uniprot
proteins
mass_dalton
46259
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:29883609}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by IRAK1 and IRAK4 enhances its E3 ligase activity. Phosphorylated by ATM in response to DNA damage, promoting localization to DNA double-strand breaks (DSBs) and ability to mediate 'Lys-63'-linked ubiquitination of NBN. {ECO:0000250|UniProtKB:Q96FA3}.; PTM: Sumoylated. {ECO:0000250|UniProtKB:Q96FA3}.
uniprot
proteins
protein_family
Pellino family
uniprot
proteins
pubmed
11306823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16951688
uniprot
proteins
pubmed
29883609
uniprot
proteins
pubmed
31142803
uniprot
proteins
pubmed
33215753
uniprot
proteins
pubmed
34706239
uniprot
proteins
sequence_length
418
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q96FA3}. Note=Localizes to DNA double-strand breaks (DSBs) in response to DNA damage. {ECO:0000250|UniProtKB:Q96FA3}.
uniprot
proteins