BLOC1S1
entrez
2647
canonical
uniprot
P78537
canonical
ensembl
ENSG00000135441
resolver
ensp
ENSP00000447537
resolver
genesymbol
BLOC1S1
resolver
genesymbol_syn
BLOS1
resolver
genesymbol_syn
GCN5L1
resolver
genesymbol_syn
RT14
resolver
hgnc
HGNC:4200
resolver
uniprot
A1L4Q9
resolver
uniprot
Q6NZ45
resolver
uniprot_entry
BL1S1_HUMAN
resolver
uniprot_sec
A1L4Q9
resolver
uniprot_sec
Q6NZ45
resolver
amino_acid_sequence
MAPGSRGERSSFRSRRGPGVPSPQPDVTMLSRLLKEHQAKQNERKELQEKRRREAITAATCLTEALVDHLNVGVAQAYMNQRKLDHEVKTLQVQAAQFAKQTGQWIGMVENFNQALKEIGDVENWARSIELDMRTIATALEYVYKGQLQSAPS
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
function
FUNCTION: Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes (PubMed:17182842). In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals (PubMed:17182842). The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension (PubMed:17182842). As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery (PubMed:25898167). Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). {ECO:0000269|PubMed:17182842, ECO:0000269|PubMed:25898167}.; FUNCTION: Acts as a protein acetyltransferase (PubMed:22309213, PubMed:38281616). Negatively regulates aerobic respiration through mitochondrial protein lysine-acetylation (PubMed:22309213). May counteract the action of the deacetylase SIRT3 by acetylating and regulating proteins of the mitochondrial respiratory chain including ATP5F1A and NDUFA9 (PubMed:22309213). Acts as a regulator of mTORC2 signaling in response to hypotoxic stress by mediating acetylation of RICTOR, thereby protecting RICTOR against ubiquitination and subsequent degradation by the proteasome (PubMed:38281616). {ECO:0000269|PubMed:22309213, ECO:0000269|PubMed:38281616}.
uniprot
proteins
mass_dalton
17263
uniprot
proteins
protein_family
BLOC1S1 family
uniprot
proteins
pubmed
15102850
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17182842
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22203680
uniprot
proteins
pubmed
22309213
uniprot
proteins
pubmed
25898167
uniprot
proteins
pubmed
38281616
uniprot
proteins
pubmed
8646881
uniprot
proteins
pubmed
8770567
uniprot
proteins
sequence_length
153
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000269|PubMed:22309213}. Mitochondrion matrix {ECO:0000269|PubMed:22309213}. Cytoplasm, cytosol {ECO:0000269|PubMed:22309213}. Lysosome membrane {ECO:0000305|PubMed:25898167}.
uniprot
proteins