P2RX4
entrez
5025
canonical
uniprot
Q99571
canonical
ensembl
ENSG00000135124
resolver
ensp
ENSP00000336607
resolver
ensp
ENSP00000353032
resolver
ensp
ENSP00000438329
resolver
ensp
ENSP00000643762
resolver
ensp
ENSP00000688876
resolver
ensp
ENSP00000750676
resolver
genesymbol
P2RX4
resolver
hgnc
HGNC:8535
resolver
uniprot
E7EPF7
resolver
uniprot
F6RU17
resolver
uniprot
O00450
resolver
uniprot
O14722
resolver
uniprot
Q5U089
resolver
uniprot
Q5U090
resolver
uniprot
Q8N4N1
resolver
uniprot
Q9UBG9
resolver
uniprot_entry
P2RX4_HUMAN
resolver
uniprot_sec
E7EPF7
resolver
uniprot_sec
F6RU17
resolver
uniprot_sec
O00450
resolver
uniprot_sec
O14722
resolver
uniprot_sec
Q5U089
resolver
uniprot_sec
Q5U090
resolver
uniprot_sec
Q8N4N1
resolver
uniprot_sec
Q9UBG9
resolver
activity_regulation
ACTIVITY REGULATION: Activated by ATP (PubMed:9016352). pH-dependent and inhibited by acidic pH (By similarity). {ECO:0000250|UniProtKB:P51577, ECO:0000269|PubMed:9016352}.
uniprot
proteins
amino_acid_sequence
MAGCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSVVSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIPDATTVCKSDASCTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLKAAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAGHSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYYRDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYCMKKRLYYREKKYKYVEDYEQGLASELDQ
uniprot
proteins
function
FUNCTION: ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (PubMed:9016352). CTP, but not GTP or UTP, functions as a weak affinity agonist for P2RX4 (By similarity). Activated by extracellularly released ATP, it plays multiple role in immunity and central nervous system physiology (PubMed:35165166). Plays a key role in initial steps of T-cell activation and Ca(2+) microdomain formation (By similarity). Also participates in basal T-cell activity without TCR/CD3 stimulation (By similarity). Promotes the differentiation and activation of Th17 cells via expression of retinoic acid-related orphan receptor C/RORC (PubMed:35165166). Upon activation, drives microglia motility via the PI3K/Akt pathway (By similarity). Could also function as an ATP-gated cation channel of lysosomal membranes (By similarity). {ECO:0000250|UniProtKB:P51577, ECO:0000250|UniProtKB:Q9JJX6, ECO:0000269|PubMed:35165166, ECO:0000269|PubMed:9016352}.
uniprot
proteins
mass_dalton
43369
uniprot
proteins
mutagenesis
MUTAGEN 119; /note="I->V: Does not change ATP-induced inward current. Does not change affinity for ATP."; /evidence="ECO:0000269|PubMed:22068874
uniprot
proteins
protein_family
P2X receptor family
uniprot
proteins
pubmed
10515189
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
22068874
uniprot
proteins
pubmed
23303206
uniprot
proteins
pubmed
24817123
uniprot
proteins
pubmed
26456657
uniprot
proteins
pubmed
28326637
uniprot
proteins
pubmed
35165166
uniprot
proteins
pubmed
9016352
uniprot
proteins
sequence_length
388
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10515189, ECO:0000269|PubMed:23303206, ECO:0000269|PubMed:28326637}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F8W463}. Lysosome membrane {ECO:0000269|PubMed:24817123}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..54; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 339..359; /note="Helical; Name=2"; /evidence="ECO:0000255
uniprot
proteins