SCTR
entrez
6344
canonical
uniprot
P47872
canonical
ensembl
ENSG00000080293
resolver
ensp
ENSP00000019103
resolver
ensp
ENSP00000573334
resolver
enst
ENST00000019103
resolver
genesymbol
SCTR
resolver
hgnc
HGNC:10608
resolver
uniprot
Q12961
resolver
uniprot
Q13213
resolver
uniprot
Q53T00
resolver
uniprot
Q8IV17
resolver
uniprot_entry
Q8IV17_HUMAN
resolver
uniprot_entry
SCTR_HUMAN
resolver
uniprot_sec
Q12961
resolver
uniprot_sec
Q13213
resolver
uniprot_sec
Q53T00
resolver
amino_acid_sequence
MRPHLSPPLQQLLLPVLLACAAHSTGALPRLCDVLQVLWEEQDQCLQELSREQTGDLGTEQPVPGCEGMWDNISCWPSSVPGRMVEVECPRFLRMLTSRNGSLFRNCTQDGWSETFPRPNLACGVNVNDSSNEKRHSYLLKLKVMYTVGYSSSLVMLLVALGILCAFRRLHCTRNYIHMHLFVSFILRALSNFIKDAVLFSSDDVTYCDAHRAGCKLVMVLFQYCIMANYSWLLVEGLYLHTLLAISFFSERKYLQGFVAFGWGSPAIFVALWAIARHFLEDVGCWDINANASIWWIIRGPVILSILINFILFINILRILMRKLRTQETRGNEVSHYKRLARSTLLLIPLFGIHYIVFAFSPEDAMEIQLFFELALGSFQGLVVAVLYCFLNGEVQLEVQKKWQQWHLREFPLHPVASFSNSTKASHLEQSQGTCRTSII
uniprot
proteins
function
FUNCTION: G protein-coupled receptor activated by secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis (PubMed:25332973, PubMed:32811827, PubMed:33008599, PubMed:7612008). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and activates cAMP-dependent pathway (PubMed:32811827, PubMed:33008599). Upon binding to secretin, regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (By similarity). In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes. Also plays an important role in cellular osmoregulation by regulating renal water reabsorption. Also plays a role in the central nervous system: required for synaptic plasticity (By similarity). {ECO:0000250|UniProtKB:P11384, ECO:0000250|UniProtKB:Q5FWI2, ECO:0000269|PubMed:32811827, ECO:0000269|PubMed:33008599, ECO:0000269|PubMed:7612008, ECO:0000303|PubMed:25332973}.
uniprot
proteins
mass_dalton
50207
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser and Thr residues at the cytoplasmic C-terminus by G protein-coupled receptor kinases (GRKs). {ECO:0000250|UniProtKB:P23811}.
uniprot
proteins
protein_family
G protein-coupled receptor 2 family
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
25332973
uniprot
proteins
pubmed
32811827
uniprot
proteins
pubmed
33008599
uniprot
proteins
pubmed
7612008
uniprot
proteins
pubmed
7700244
uniprot
proteins
pubmed
7864894
uniprot
proteins
sequence_length
440
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5FWI2}; Multi-pass membrane protein {ECO:0000269|PubMed:32811827}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q5FWI2}; Multi-pass membrane protein {ECO:0000269|PubMed:32811827}.
uniprot
proteins
transmembrane_region
TRANSMEM 142..167; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:32811827, ECO:0007744|PDB:6WI9"; TRANSMEM 175..195; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:32811827, ECO:0007744|PDB:6WI9"; TRANSMEM 217..239; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:32811827, ECO:0007744|PDB:6WI9"; TRANSMEM 255..276; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:32811827, ECO:0007744|PDB:6WI9"; TRANSMEM 292..315; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:32811827, ECO:0007744|PDB:6WI9"; TRANSMEM 341..356; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:32811827, ECO:0007744|PDB:6WI9"; TRANSMEM 368..391; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:32811827, ECO:0007744|PDB:6WI9
uniprot
proteins