FAS
entrez
355
canonical
uniprot
P25445
canonical
ensembl
ENSG00000026103
resolver
ensp
ENSP00000347426
resolver
ensp
ENSP00000347979
resolver
ensp
ENSP00000349896
resolver
ensp
ENSP00000498466
resolver
ensp
ENSP00000509810
resolver
ensp
ENSP00000512813
resolver
enst
ENST00000355740
resolver
enst
ENST00000477270
resolver
enst
ENST00000690268
resolver
genesymbol
FAS
resolver
genesymbol_syn
APT1
resolver
genesymbol_syn
FAS1
resolver
genesymbol_syn
TNFRSF6
resolver
hgnc
HGNC:11920
resolver
uniprot
A0A499FID1
resolver
uniprot
A0A8I5KWV4
resolver
uniprot
A0A8Q3SIR6
resolver
uniprot
A9UJX4
resolver
uniprot
B6VNV4
resolver
uniprot
K9J972
resolver
uniprot
Q14292
resolver
uniprot
Q14293
resolver
uniprot
Q14294
resolver
uniprot
Q14295
resolver
uniprot
Q16652
resolver
uniprot
Q59FU8
resolver
uniprot
Q5T9P1
resolver
uniprot
Q5T9P2
resolver
uniprot
Q5T9P3
resolver
uniprot
Q6SSE9
resolver
uniprot_entry
A0A499FID1_HUMAN
resolver
uniprot_entry
A0A8I5KWV4_HUMAN
resolver
uniprot_entry
A0A8Q3SIR6_HUMAN
resolver
uniprot_entry
K9J972_HUMAN
resolver
uniprot_entry
Q59FU8_HUMAN
resolver
uniprot_entry
TNR6_HUMAN
resolver
uniprot_sec
A9UJX4
resolver
uniprot_sec
B6VNV4
resolver
uniprot_sec
Q14292
resolver
uniprot_sec
Q14293
resolver
uniprot_sec
Q14294
resolver
uniprot_sec
Q14295
resolver
uniprot_sec
Q16652
resolver
uniprot_sec
Q5T9P1
resolver
uniprot_sec
Q5T9P2
resolver
uniprot_sec
Q5T9P3
resolver
uniprot_sec
Q6SSE9
resolver
amino_acid_sequence
MLGIWTLLPLVLTSVARLSSKSVNAQVTDINSKGLELRKTVTTVETQNLEGLHHDGQFCHKPCPPGERKARDCTVNGDEPDCVPCQEGKEYTDKAHFSSKCRRCRLCDEGHGLEVEINCTRTQNTKCRCKPNFFCNSTVCEHCDPCTKCEHGIIKECTLTSNTKCKEEGSRSNLGWLCLLLLPIPLIVWVKRKEVQKTCRKHRKENQGSHESPTLNPETVAINLSDVDLSKYITTIAGVMTLSQVKGFVRKNGVNEAKIDEIKNDNVQDTAEQKVQLLRNWHQLHGKKEAYDTLIKDLKKANLCTLAEKIQTIILKDITSDSENSNFRNEIQSLV
uniprot
proteins
disease_involvement
DISEASE: Autoimmune lymphoproliferative syndrome 1A (ALPS1A) [MIM:601859]: A disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia. {ECO:0000269|PubMed:10090885, ECO:0000269|PubMed:10340403, ECO:0000269|PubMed:10515860, ECO:0000269|PubMed:11418480, ECO:0000269|PubMed:17336828, ECO:0000269|PubMed:20935634, ECO:0000269|PubMed:7540117, ECO:0000269|PubMed:8929361, ECO:0000269|PubMed:9028321, ECO:0000269|PubMed:9028957, ECO:0000269|PubMed:9322534, ECO:0000269|PubMed:9821419, ECO:0000269|PubMed:9927496}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). {ECO:0000269|PubMed:19118384, ECO:0000269|PubMed:7533181, ECO:0000269|PubMed:9184224}.
uniprot
proteins
mass_dalton
37732
uniprot
proteins
mutagenesis
MUTAGEN 199; /note="C->V: Loss of palmitoylation."; /evidence="ECO:0000269|PubMed:25301068"; MUTAGEN 250; /note="R->A: Abolished GlcNAcylation by E.coli NleB1."; /evidence="ECO:0000269|PubMed:30979585"; MUTAGEN 250; /note="R->E: Strongly decreased interaction with FADD."; /evidence="ECO:0000269|PubMed:20935634"; MUTAGEN 261; /note="E->K: Loss of interaction with FADD."; /evidence="ECO:0000269|PubMed:20935634"; MUTAGEN 283; /note="Q->K: Loss of interaction with FADD."; /evidence="ECO:0000269|PubMed:20935634"; MUTAGEN 287; /note="K->D: Strongly decreased interaction with FADD."; /evidence="ECO:0000269|PubMed:20935634"; MUTAGEN 291; /note="Y->D: Decreased interaction with FADD."; /evidence="ECO:0000269|PubMed:19118384"; MUTAGEN 313; /note="I->D: Constitutive activation. Promotes apoptosis, both in the presence and in the absence of stimulation by a ligand."; /evidence="ECO:0000269|PubMed:19118384
uniprot
proteins
post_translational_modification
PTM: (Microbial infection) Glycosylated at Arg-250 by enteropathogenic E.coli protein NleB1: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions. {ECO:0000305|PubMed:23955153}.; PTM: Palmitoylated (PubMed:25301068). Palmitoylation by ZDHHC7 prevents the lysosomal degradation of FAS regulating its expression at the plasma membrane (PubMed:25301068). {ECO:0000269|PubMed:25301068}.; PTM: N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. {ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:22171320}.
uniprot
proteins
pubmed
10090885
uniprot
proteins
pubmed
10340403
uniprot
proteins
pubmed
10515860
uniprot
proteins
pubmed
10535980
uniprot
proteins
pubmed
10542291
uniprot
proteins
pubmed
10620127
uniprot
proteins
pubmed
11418480
uniprot
proteins
pubmed
1375228
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14759258
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15465831
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1713127
uniprot
proteins
pubmed
17336828
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
18846110
uniprot
proteins
pubmed
19118384
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20935634
uniprot
proteins
pubmed
21109225
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22171320
uniprot
proteins
pubmed
23955153
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24914971
uniprot
proteins
pubmed
25301068
uniprot
proteins
pubmed
30979585
uniprot
proteins
pubmed
7533181
uniprot
proteins
pubmed
7538908
uniprot
proteins
pubmed
7540117
uniprot
proteins
pubmed
7575433
uniprot
proteins
pubmed
8598453
uniprot
proteins
pubmed
8648105
uniprot
proteins
pubmed
8929361
uniprot
proteins
pubmed
8967952
uniprot
proteins
pubmed
9028321
uniprot
proteins
pubmed
9028957
uniprot
proteins
pubmed
9184224
uniprot
proteins
pubmed
9322534
uniprot
proteins
pubmed
9787134
uniprot
proteins
pubmed
9821419
uniprot
proteins
pubmed
9927496
uniprot
proteins
sequence_length
335
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:1713127, ECO:0000269|PubMed:25301068}; Single-pass type I membrane protein {ECO:0000305}. Membrane raft {ECO:0000269|PubMed:25301068}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted.; SUBCELLULAR LOCATION: [Isoform 6]: Secreted.
uniprot
proteins
transmembrane_region
TRANSMEM 174..190; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins