Cd4
entrez
12504
canonical
uniprot
P06332
canonical
ensembl
ENSMUSG00000023274
resolver
ensp
ENSMUSP00000024044
resolver
genesymbol
Cd4
resolver
uniprot
Q3TSV7
resolver
uniprot_entry
CD4_MOUSE
resolver
uniprot_entry
Q3TSV7_MOUSE
resolver
amino_acid_sequence
MCRAISLRRLLLLLLQLSQLLAVTQGKTLVLGKEGESAELPCESSQKKITVFTWKFSDQRKILGQHGKGVLIRGGSPSQFDRFDSKKGAWEKGSFPLIINKLKMEDSQTYICELENRKEEVELWVFKVTFSPGTSLLQGQSLTLTLDSNSKVSNPLTECKHKKGKVVSGSKVLSMSNLRVQDSDFWNCTVTLDQKKNWFGMTLSVLGFQSTAITAYKSEGESAEFSFPLNFAEENGWGELMWKAEKDSFFQPWISFSIKNKEVSVQKSTKDLKLQLKETLPLTLKIPQVSLQFAGSGNLTLTLDKGTLHQEVNLVVMKVAQLNNTLTCEVMGPTSPKMRLTLKQENQEARVSEEQKVVQVVAPETGLWQCLLSEGDKVKMDSRIQVLSRGVNQTVFLACVLGGSFGFLGFLGLCILCCVRCRHQQRQAARMSQIKRLLSEKKTCQCPHRMQKSHNLI
uniprot
proteins
function
FUNCTION: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages. {ECO:0000250|UniProtKB:P01730, ECO:0000269|PubMed:16709847, ECO:0000269|PubMed:1832488, ECO:0000269|PubMed:2784195, ECO:0000269|PubMed:3262426}.
uniprot
proteins
mass_dalton
51297
uniprot
proteins
post_translational_modification
PTM: Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts. {ECO:0000250|UniProtKB:P01730}.; PTM: Phosphorylated by PKC; phosphorylation plays an important role for CD4 internalization. {ECO:0000269|PubMed:2512251}.
uniprot
proteins
pubmed
10706685
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16709847
uniprot
proteins
pubmed
1832488
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2512251
uniprot
proteins
pubmed
2784195
uniprot
proteins
pubmed
2823269
uniprot
proteins
pubmed
3027575
uniprot
proteins
pubmed
3082751
uniprot
proteins
pubmed
3086886
uniprot
proteins
pubmed
3094146
uniprot
proteins
pubmed
3262426
uniprot
proteins
pubmed
3326818
uniprot
proteins
pubmed
9445485
uniprot
proteins
sequence_length
457
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P01730}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P01730}.
uniprot
proteins
transmembrane_region
TRANSMEM 395..417; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins