Sco1
entrez
52892
canonical
uniprot
Q5SUC9
canonical
ensembl
ENSMUSG00000069844
resolver
ensp
ENSMUSP00000090673
resolver
enst
ENSMUST00000092996
resolver
genesymbol
Sco1
resolver
uniprot
Q3UTD6
resolver
uniprot_entry
SCO1_MOUSE
resolver
uniprot_sec
Q3UTD6
resolver
amino_acid_sequence
MAALVRAAVVRSQCRQLWRLFPRGHGLRDVAERPRPEEACSCLRSRAFSAGPPPPGAGPEPKGGQAGSHRPKPGPVSWKSLALTFAIGGSLLAGMKYFKKEKIEKLEKQRHRSIGKPLLGGPFSLTTHNGEPKTDKDYLGQWVLIYFGFTHCPDICPEELEKMIEVVEEIDSIPSLPNLTPLFITIDPERDTKEAIATYVKEFSPKLVGLTGTKEEIDGVARAYRVYYSPGPKDEDEDYIVDHTIIMYLIGPDGEFLDYFGQNKKKAEIAGSIAAHMRSHMKKR
uniprot
proteins
function
FUNCTION: Copper metallochaperone essential for the maturation of cytochrome c oxidase subunit II (MT-CO2/COX2). Together with SCO2, involved in delivering copper to the Cu(A) site on MT-CO2/COX2 (By similarity). Plays an important role in the regulation of copper homeostasis by controlling the abundance and cell membrane localization of copper transporter CTR1 (PubMed:25683716, PubMed:28973536). {ECO:0000250|UniProtKB:O75880, ECO:0000269|PubMed:25683716, ECO:0000269|PubMed:28973536}.
uniprot
proteins
mass_dalton
31617
uniprot
proteins
mutagenesis
MUTAGEN 115; /note="G->S: Knockin mice hearts exhibit a severe combined COX and copper deficiency and a mislocalization of copper transporter protein CTR1 to the cytoplasm."; /evidence="ECO:0000269|PubMed:28973536
uniprot
proteins
protein_family
SCO1/2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25683716
uniprot
proteins
pubmed
28973536
uniprot
proteins
sequence_length
284
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:O75880}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 81..98; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins