Or4m1
entrez
258658
canonical
uniprot
Q8VFT4
canonical
ensembl
ENSMUSG00000045306
resolver
ensp
ENSMUSP00000057376
resolver
ensp
ENSMUSP00000150732
resolver
enst
ENSMUST00000050928
resolver
enst
ENSMUST00000217152
resolver
genesymbol
Or4m1
resolver
genesymbol_syn
Olfr734
resolver
uniprot_entry
OR4M1_MOUSE
resolver
amino_acid_sequence
MEPANDTTVTEFILTGLSQTREVQLVLFVIFLSFYLFILPVNILIICTIRLDSHLSSPMYFLLANLAFLDIWYSSITAPKMLVDFFVERKIISFGGCIAQLFFLHFVGASEMFLLTVMAFDRYAAICRPLHYATIMNRRLCCILVALSWTGGFVHSIIQVALIVRLPFCGPNELDNYFCDITQVVRIACANTFLEEMVMIFSSGLISVVCFIALLMSYAFLLTMLKKHSSSGESTSRAISTCYSHITIVVLMFGPSIYIYARPFDSFSLDKVVSVFHTVIFPLLNPIIYTLRNKEVKAAMRKLVNRYIFCKEK
uniprot
proteins
function
FUNCTION: Olfactory receptor that acts as a receptor of Asprosin hormone at the surface of hepatocytes to promote hepatocyte glucose release (PubMed:31230984). Also binds Asprosin in the arcuate nucleus of the hypothalamus, thereby stimulating appetite by promoting orexigenic AgRP neuronal activity (PubMed:32337066). In testis, Asprosin-binding promotes sperm progressive motility and enhances male fertility (PubMed:31798959). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase, resulting in an elevation of intracellular cAMP (PubMed:31230984). {ECO:0000269|PubMed:31230984, ECO:0000269|PubMed:31798959, ECO:0000269|PubMed:32337066}.
uniprot
proteins
mass_dalton
35601
uniprot
proteins
mutagenesis
MUTAGEN 173; /note="E->A: Reduced affinity for Asprosin."; /evidence="ECO:0000269|PubMed:31230984"; MUTAGEN 186; /note="R->D: Reduced affinity for Asprosin."; /evidence="ECO:0000269|PubMed:31230984
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11802173
uniprot
proteins
pubmed
11875048
uniprot
proteins
pubmed
14611657
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
31230984
uniprot
proteins
pubmed
31798959
uniprot
proteins
pubmed
32337066
uniprot
proteins
sequence_length
313
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:31230984}; Multi-pass membrane protein {ECO:0000255|RuleBase:RU363047}.
uniprot
proteins
transmembrane_region
TRANSMEM 26..46; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 58..78; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 98..118; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 143..163; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 205..225; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 239..259; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 271..291; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins