RAC3
entrez
5881
canonical
uniprot
P60763
canonical
ensembl
ENSG00000169750
resolver
ensp
ENSP00000304283
resolver
ensp
ENSP00000774015
resolver
enst
ENST00000306897
resolver
genesymbol
RAC3
resolver
hgnc
HGNC:9803
resolver
uniprot
O14658
resolver
uniprot
Q5U0M8
resolver
uniprot_entry
RAC3_HUMAN
resolver
uniprot_sec
O14658
resolver
uniprot_sec
Q5U0M8
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. Regulated by the GEF protein DOCK7. {ECO:0000269|PubMed:16982419}.
uniprot
proteins
amino_acid_sequence
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPHTPILLVGTKLDLRDDKDTIERLRDKKLAPITYPQGLAMAREIGSVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKPGKKCTVF
uniprot
proteins
disease_involvement
DISEASE: Neurodevelopmental disorder with structural brain anomalies and dysmorphic facies (NEDBAF) [MIM:618577]: An autosomal dominant neurodevelopmental disorder characterized by global developmental delay, severe intellectual disability, poor language, seizures, dysmorphic features, and thin corpus callosum. {ECO:0000269|PubMed:29276006, ECO:0000269|PubMed:30293988}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner. {ECO:0000269|PubMed:11756406, ECO:0000269|PubMed:11956649}.
uniprot
proteins
mass_dalton
21379
uniprot
proteins
mutagenesis
MUTAGEN 166; /note="K->R: Reduced FBXL19-mediated ubiquitination and subsequent degradation."; /evidence="ECO:0000269|PubMed:24684802
uniprot
proteins
post_translational_modification
PTM: (Microbial infection) Glycosylated at Tyr-32 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rac and leads to actin disassembly. {ECO:0000269|PubMed:24141704}.; PTM: Ubiquitinated at Lys-166 in a FBXL19-mediated manner; leading to proteasomal degradation. {ECO:0000269|PubMed:24684802}.
uniprot
proteins
protein_family
Rho family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
11756406
uniprot
proteins
pubmed
11956649
uniprot
proteins
pubmed
15107133
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16982419
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24141704
uniprot
proteins
pubmed
24684802
uniprot
proteins
pubmed
29276006
uniprot
proteins
pubmed
30293988
uniprot
proteins
pubmed
9252344
uniprot
proteins
pubmed
9852280
uniprot
proteins
sequence_length
192
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15107133}. Endomembrane system. Cell projection, lamellipodium. Cytoplasm, perinuclear region. Cell membrane. Cytoplasm, cytoskeleton. Note=Membrane-associated when activated. Localizes to actin-based membrane ruffles (PubMed:15107133). Colocalizes with NRBP to endomembranes and at the cell periphery in lamellipodia. Colocalized with CIB1 in the perinuclear area and at the cell periphery. {ECO:0000269|PubMed:15107133}.
uniprot
proteins