Gskip
entrez
362778
canonical
uniprot
Q5PPI3
canonical
genesymbol
Gskip
resolver
uniprot_entry
GSKIP_RAT
resolver
amino_acid_sequence
METDCNPVDLSSMSGFEEGSELNGFEGTDMKDMQLEAEAVVNDVLFAVNNMFVSKSLPCADDVAYINVETKERNRYCLELTEAGLRVVGYAFDQVEDHLQTPYHETVYSLLDTLSPAYREAFGNALLQRLEALKRDGQS
uniprot
proteins
function
FUNCTION: A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (By similarity). May play a role in cleft palate formation and is required for postnatal life through modulation of the activity of GSK3B during development (By similarity). {ECO:0000250|UniProtKB:Q8BGR8, ECO:0000250|UniProtKB:Q9P0R6}.
uniprot
proteins
mass_dalton
15557
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by GSK3B. {ECO:0000250|UniProtKB:Q9P0R6}.
uniprot
proteins
protein_family
GSKIP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20007971
uniprot
proteins
sequence_length
139
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9P0R6}. Nucleus {ECO:0000250|UniProtKB:Q9P0R6}.
uniprot
proteins