Pacc1
entrez
66950
canonical
uniprot
Q9D771
canonical
ensembl
ENSMUSG00000026627
resolver
ensp
ENSMUSP00000027940
resolver
enst
ENSMUST00000027940
resolver
genesymbol
Pacc1
resolver
genesymbol_syn
Tmem206
resolver
uniprot_entry
PACC1_MOUSE
resolver
amino_acid_sequence
MIRQELSTSYQELSEELEQVVENSEQADERDKELVQVQGPGVVPGVDNESASSSIRFSKACLKNVFSVLLILIYLLLMAVAVFLVYQTITDFREKLKHPVMSVSYKEVDRYDAPGIAFYPGQAQLLSCKHHYEVIPPLASPGQPGDRNCTTQRINYTHPFFNHTMQSALIVQGPQEVKKRELVFLQFRLNQSNEDFSAIDYLLFSSFREFMQSPDKAGFMQACESAYSSWKFSGGFRTWVKMSLVKTKEEDGREAVEFRQETSVVNYIDQRPAAERSAQLFFVVFEWKDPFIQKVQDIITANPWNTIALLCGAFLALFKAAEFAKLSVKWMIKIRKRYLKRRGQATNHIS
uniprot
proteins
function
FUNCTION: Chloride channel gated by pH that facilitates the entry of chloride ions into cells upon exposure to extracellular acidic pH (PubMed:31023925). Involved in acidosis-induced cell death by mediating chloride influx and subsequent cell swelling (PubMed:31023925). {ECO:0000269|PubMed:31023925}.
uniprot
proteins
mass_dalton
40178
uniprot
proteins
protein_family
Proton-activated chloride channel family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31023925
uniprot
proteins
sequence_length
350
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9H813}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9H813}.
uniprot
proteins
transmembrane_region
TRANSMEM 65..85; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 302..318; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins