Kcnd3
entrez
56543
canonical
uniprot
Q9Z0V1
canonical
ensembl
ENSMUSG00000040896
resolver
ensp
ENSMUSP00000078169
resolver
ensp
ENSMUSP00000096357
resolver
genesymbol
Kcnd3
resolver
uniprot
B2RUE0
resolver
uniprot
Q3UH54
resolver
uniprot
Q8CC44
resolver
uniprot
Q9Z0V0
resolver
uniprot_entry
B2RUE0_MOUSE
resolver
uniprot_entry
KCND3_MOUSE
resolver
uniprot_entry
Q3UH54_MOUSE
resolver
uniprot_sec
Q8CC44
resolver
uniprot_sec
Q9Z0V0
resolver
amino_acid_sequence
MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERLMDDNDSENNQESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEQMGKTTSLIESQHHHLLHCLEKTTGLSYLVDDPLLSVRTSTIKNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHSGLTTTCCSRRSKKTTHLPNSNLPATRLRSMQELSTLHIQGSEQPSLTTSRSSLNLKADDGLRPNCKTSQITTAIISIPTPPALTPEGESRPPPASPGPNTNIPSITSNVVKVSAL
uniprot
proteins
function
FUNCTION: Pore-forming (alpha) subunit of voltage-gated A-type potassium channels that mediates transmembrane potassium transport in excitable membranes, in brain and heart (By similarity). In cardiomyocytes, may generate the transient outward potassium current I(To). In neurons, may conduct the transient subthreshold somatodendritic A-type potassium current (ISA) (By similarity). Kinetics properties are characterized by fast activation at subthreshold membrane potentials, rapid inactivation, and quick recovery from inactivation. Channel properties are modulated by interactions with regulatory subunits. Interaction with the regulatory subunits KCNIP1 or KCNIP2 modulates the channel gating kinetics namely channel activation and inactivation kinetics and rate of recovery from inactivation. Likewise, interaction with DPP6 modulates the channel gating kinetics namely channel activation and inactivation kinetics (By similarity). {ECO:0000250|UniProtKB:Q62897, ECO:0000250|UniProtKB:Q9UK17}.
uniprot
proteins
mass_dalton
73462
uniprot
proteins
post_translational_modification
PTM: Regulated through phosphorylation at Ser-569 by CaMK2D. {ECO:0000250|UniProtKB:Q62897}.
uniprot
proteins
protein_family
D (Shal) (TC 1.A.1.2) subfamily
uniprot
proteins
protein_family
Kv4.3/KCND3 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
11598014
uniprot
proteins
pubmed
11909823
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19713751
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
655
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q62897}; Multi-pass membrane protein {ECO:0000255}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q62897}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q62897}. Note=Interaction with palmitoylated KCNIP2 and KCNIP3 enhances cell surface expression. {ECO:0000250|UniProtKB:Q62897}.
uniprot
proteins
transmembrane_region
TRANSMEM 183..204; /note="Helical; Name=Segment S1"; /evidence="ECO:0000250|UniProtKB:Q9UK17"; TRANSMEM 224..246; /note="Helical; Name=Segment S2"; /evidence="ECO:0000250|UniProtKB:Q9UK17"; TRANSMEM 254..277; /note="Helical; Name=Segment S3"; /evidence="ECO:0000250|UniProtKB:Q9UK17"; TRANSMEM 284..306; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000250|UniProtKB:Q9UK17"; TRANSMEM 319..343; /note="Helical; Name=Segment S5"; /evidence="ECO:0000250|UniProtKB:Q9UK17"; TRANSMEM 378..400; /note="Helical; Name=Segment S6"; /evidence="ECO:0000250|UniProtKB:Q9UK17
uniprot
proteins