TATDN3
entrez
128387
canonical
uniprot
Q17R31
canonical
ensembl
ENSG00000203705
resolver
ensp
ENSP00000355940
resolver
ensp
ENSP00000355941
resolver
ensp
ENSP00000431376
resolver
ensp
ENSP00000433755
resolver
ensp
ENSP00000434801
resolver
ensp
ENSP00000436364
resolver
ensp
ENSP00000553618
resolver
ensp
ENSP00000553619
resolver
ensp
ENSP00000620543
resolver
ensp
ENSP00000766843
resolver
enst
ENST00000526997
resolver
genesymbol
TATDN3
resolver
hgnc
HGNC:27010
resolver
uniprot
A6NGS3
resolver
uniprot
B7Z1C1
resolver
uniprot
B7Z2Z9
resolver
uniprot
B7Z978
resolver
uniprot
B7ZLQ6
resolver
uniprot
E9PJE5
resolver
uniprot
E9PNH3
resolver
uniprot
E9PP81
resolver
uniprot
G3V151
resolver
uniprot
Q4G0L1
resolver
uniprot_entry
B7Z2Z9_HUMAN
resolver
uniprot_entry
E9PP81_HUMAN
resolver
uniprot_entry
TATD3_HUMAN
resolver
uniprot_sec
A6NGS3
resolver
uniprot_sec
B7Z1C1
resolver
uniprot_sec
B7Z978
resolver
uniprot_sec
B7ZLQ6
resolver
uniprot_sec
E9PJE5
resolver
uniprot_sec
E9PNH3
resolver
uniprot_sec
G3V151
resolver
uniprot_sec
Q4G0L1
resolver
activity_regulation
ACTIVITY REGULATION: The 3'-exonuclease activity is sensitive to the metal ion present in the active site, whereas the AP endodeoxyribonuclease activity is observed in a variety of divalent metal cofactors. 3'-exoxonuclease activity is suppressed in the presence of Ca(2+), Zn(2+) and Ni(2+). {ECO:0000269|PubMed:36881763}.
uniprot
proteins
amino_acid_sequence
MRAAGVGLVDCHCHLSAPDFDRDLDDVLEKAKKANVVALVAVAEHSGEFEKIMQLSERYNGFVLPCLGVHPVQGLPPEDQRSVTLKDLDVALPIIENYKDRLLAIGEVGLDFSPRFAGTGEQKEEQRQVLIRQIQLAKRLNLPVNVHSRSAGRPTINLLQEQGAEKVLLHAFDGRPSVAMEGVRAGYFFSIPPSIIRSGQKQKLVKQLPLTSICLETDSPALGPEKQVRNEPWNISISAEYIAQVKGISVEEVIEVTTQNALKLFPKLRHLLQK
uniprot
proteins
ec_number
3.1.11.-
uniprot
proteins
ec_number
3.1.21.-
uniprot
proteins
function
FUNCTION: Exhibits 3'-exonuclease and apurinic/apyrimidinic (AP) endonuclease activities (in vitro). Show preferential AP endonuclease activity on double-stranded DNA substrates and 3'- exonuclease activity on single-stranded DNA. {ECO:0000269|PubMed:36881763}.
uniprot
proteins
mass_dalton
30333
uniprot
proteins
mutagenesis
MUTAGEN 107; /note="E->A: Reduces AP endodeoxyribonuclease and 3'-exonuclease activities."; /evidence="ECO:0000269|PubMed:36881763"; MUTAGEN 107; /note="E->Q: Increases both AP endodeoxyribonuclease and 3'-exonuclease activities."; /evidence="ECO:0000269|PubMed:36881763"; MUTAGEN 218; /note="D->A: Reduces both AP endodeoxyribonuclease and 3'-exonuclease activities by 30-fold."; /evidence="ECO:0000269|PubMed:36881763
uniprot
proteins
protein_family
Metallo-dependent hydrolases superfamily
uniprot
proteins
protein_family
TatD-type hydrolase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
36881763
uniprot
proteins
sequence_length
274
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins