SPESP1
entrez
246777
canonical
uniprot
Q6UW49
canonical
ensembl
ENSG00000258484
resolver
ensp
ENSP00000312284
resolver
enst
ENST00000310673
resolver
genesymbol
SPESP1
resolver
hgnc
HGNC:15570
resolver
uniprot
Q8NG22
resolver
uniprot
Q8WVH8
resolver
uniprot_entry
SPESP_HUMAN
resolver
uniprot_sec
Q8NG22
resolver
uniprot_sec
Q8WVH8
resolver
amino_acid_sequence
MKPLVLLVALLLWPSSVPAYPSITVTPDEEQNLNHYIQVLENLVRSVPSGEPGREKKSNSPKHVYSIASKGSKFKELVTHGDASTENDVLTNPISEETTTFPTGGFTPEIGKKKHTESTPFWSIKPNNVSIVLHAEEPYIENEEPEPEPEPAAKQTEAPRMLPVVTESSTSPYVTSYKSPVTTLDKSTGIGISTESEDVPQLSGETAIEKPEEFGKHPESWNNDDILKKILDINSQVQQALLSDTSNPAYREDIEASKDHLKRSLALAAAAEHKLKTMYKSQLLPVGRTSNKIDDIETVINMLCNSRSKLYEYLDIKCVPPEMREKAATVFNTLKNMCRSRRVTALLKVY
uniprot
proteins
function
FUNCTION: Involved in fertilization ability of sperm. {ECO:0000250|UniProtKB:Q9D5A0}.
uniprot
proteins
mass_dalton
38931
uniprot
proteins
post_translational_modification
PTM: Glycosylated. In testis there are two predominant forms of 77- and 67-kDa and a form of 47-kDa, whereas in epididymal sperm from caput, corpus, and cauda there are two forms of 47- and 43-kDa. Testis forms contain complex carbohydrate residues. Epididymal sperm forms are N-glycosylated. Then undergoes significant glycosylation in the testis and that the majority of these glycoconjugates are removed by the time sperm reach the caput epididymis. {ECO:0000250|UniProtKB:Q9D5A0}.
uniprot
proteins
protein_family
SPESP1 family
uniprot
proteins
pubmed
12773409
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
sequence_length
350
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:12773409}. Note=Small proacrosomal granules (during the Golgi phase), enlarged acrosomal vesicles (during the cap phase), acrosome (during the elongating phase), equatorial segment of the acrosome (during the maturation phase) (PubMed:12773409). After acrosome reaction localizes to the equatorial segment region in both noncapacitated and capacitated, acrosome-reacted sperm (By similarity). {ECO:0000250|UniProtKB:Q9D5A0, ECO:0000269|PubMed:12773409}.
uniprot
proteins