Cd86
entrez
12524
canonical
uniprot
P42082
canonical
ensembl
ENSMUSG00000022901
resolver
ensp
ENSMUSP00000087047
resolver
genesymbol
Cd86
resolver
genesymbol_syn
B7-2
resolver
uniprot
Q549Q9
resolver
uniprot
Q61238
resolver
uniprot_entry
CD86_MOUSE
resolver
uniprot_entry
Q549Q9_MOUSE
resolver
uniprot_entry
Q61238_MOUSE
resolver
amino_acid_sequence
MDPRCTMGLAILIFVTVLLISDAVSVETQAYFNGTAYLPCPFTKAQNISLSELVVFWQDQQKLVLYEHYLGTEKLDSVNAKYLGRTSFDRNNWTLRLHNVQIKDMGSYDCFIQKKPPTGSIILQQTLTELSVIANFSEPEIKLAQNVTGNSGINLTCTSKQGHPKPKKMYFLITNSTNEYGDNMQISQDNVTELFSISNSLSLSFPDGVWHMTVVCVLETESMKISSKPLNFTQEFPSPQTYWKEITASVTVALLLVMLLIIVCHKKPNQPSRPSNTASKLERDSNADRETINLKELEPQIASAKPNAE
uniprot
proteins
function
FUNCTION: Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation (By similarity). Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells by acting as a ligand for the CD28 receptor which is constitutively expressed on the cell surface of T-cells (By similarity). May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation (By similarity). Also involved in the regulation of B cells function, plays a role in regulating the level of IgG(1) produced (PubMed:23241883). Upon CD40 engagement, activates NF-kappa-B signaling pathway via phospholipase C and protein kinase C activation (PubMed:23241883). Also acts as an inhibitor of T-cell activation by acting as a ligand for CTLA4, a decoy receptor, thereby blocking CD28-mediated T-cell priming (PubMed:7504059, PubMed:7513726). {ECO:0000250|UniProtKB:P42081, ECO:0000269|PubMed:23241883, ECO:0000269|PubMed:7504059, ECO:0000269|PubMed:7513726}.
uniprot
proteins
mass_dalton
34666
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation. {ECO:0000250|UniProtKB:P42081}.
uniprot
proteins
pubmed
23241883
uniprot
proteins
pubmed
7499829
uniprot
proteins
pubmed
7504059
uniprot
proteins
pubmed
7513726
uniprot
proteins
sequence_length
309
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P42081}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P42081}.
uniprot
proteins
transmembrane_region
TRANSMEM 245..265; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins