Sgms2
entrez
74442
canonical
uniprot
Q9D4B1
canonical
ensembl
ENSMUSG00000050931
resolver
ensp
ENSMUSP00000087713
resolver
ensp
ENSMUSP00000214271
resolver
ensp
ENSMUSP00000214272
resolver
ensp
ENSMUSP00000214273
resolver
ensp
ENSMUSP00000357945
resolver
enst
ENSMUST00000090246
resolver
genesymbol
Sgms2
resolver
uniprot
Q149I0
resolver
uniprot_entry
SMS2_MOUSE
resolver
uniprot_sec
Q149I0
resolver
amino_acid_sequence
MDIIETAKLEGHLESQTNDSTNTYTSPTEAVEEEGKNGKGKPKTLSNGLRKGAKKYPDYIQISMPNDSKNKFPLEWWKTGIAFVYALFNLILTTVMITVVHERVPPKELSPPLPDKFFDYFDRVKWAFSVSEINGMVLVGLWITQWLFLRYKSIVGRRFFFIMGTLYLYRCITMYVTTLPVPGMHFQCAPKLNGDSQAKIQRILRLISGGGLSITGSHILCGDFLFSGHTVVLTLTYLFIKEYSPRHFWWYHLVCWLLSAAGIICILVAHEHYTVDVIIAYYITTRLFWWYHSMANEKNLKVSSQTNFLSRAWWFPIFYFFEKNVQGSIPCCFSWPLSWPPGCFKSSCRKYSRVQKIGEDNEKST
uniprot
proteins
ec_number
2.7.8.27
uniprot
proteins
function
FUNCTION: Sphingomyelin synthase that primarily contributes to sphingomyelin synthesis and homeostasis at the plasma membrane (PubMed:19590047, PubMed:21844222, PubMed:22580896). Catalyzes the reversible transfer of phosphocholine moiety in sphingomyelin biosynthesis: in the forward reaction transfers phosphocholine head group of phosphatidylcholine (PC) on to ceramide (CER) to form ceramide phosphocholine (sphingomyelin, SM) and diacylglycerol (DAG) as by-product, and in the reverse reaction transfers phosphocholine from SM to DAG to form PC and CER. The direction of the reaction appears to depend on the levels of CER and DAG in the plasma membrane. Does not use free phosphorylcholine or CDP-choline as donors (By similarity). Can also transfer phosphoethanolamine head group of phosphatidylethanolamine (PE) on to ceramide (CER) to form ceramide phosphoethanolamine (CPE) (PubMed:25605874). Regulates receptor-mediated signal transduction via mitogenic DAG and proapoptotic CER, as well as via SM, a structural component of membrane rafts that serve as platforms for signal transduction and protein sorting (PubMed:19590047, PubMed:21844222). To a lesser extent, plays a role in secretory transport via regulation of DAG pool at the Golgi apparatus and its downstream effects on PRKD1. Required for normal bone matrix mineralization (By similarity). {ECO:0000250|UniProtKB:Q8NHU3, ECO:0000269|PubMed:19590047, ECO:0000269|PubMed:21844222, ECO:0000269|PubMed:22580896, ECO:0000269|PubMed:25605874}.
uniprot
proteins
mass_dalton
42248
uniprot
proteins
pathway_participation
PATHWAY: Sphingolipid metabolism. {ECO:0000250|UniProtKB:Q8NHU3}.
uniprot
proteins
post_translational_modification
PTM: Palmitoylated on Cys-331, Cys-332, Cys-343 and Cys-348; which plays an important role in plasma membrane localization. {ECO:0000250}.
uniprot
proteins
protein_family
Sphingomyelin synthase family
uniprot
proteins
pubmed
14685263
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19590047
uniprot
proteins
pubmed
21844222
uniprot
proteins
pubmed
22580896
uniprot
proteins
pubmed
22849442
uniprot
proteins
pubmed
25605874
uniprot
proteins
pubmed
30779713
uniprot
proteins
sequence_length
365
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8NHU3}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8NHU3}; Multi-pass membrane protein {ECO:0000255}. Note=Primarily localized at the plasma membrane with a small fraction at the Golgi apparatus. {ECO:0000250|UniProtKB:Q8NHU3}.
uniprot
proteins
transmembrane_region
TRANSMEM 80..100; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 128..148; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 159..179; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 219..239; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 248..268; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 273..290; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins