DGKQ
entrez
1609
canonical
uniprot
P52824
canonical
ensembl
ENSG00000145214
resolver
ensp
ENSP00000273814
resolver
ensp
ENSP00000603004
resolver
ensp
ENSP00000603005
resolver
ensp
ENSP00000700585
resolver
ensp
ENSP00000746539
resolver
enst
ENST00000273814
resolver
genesymbol
DGKQ
resolver
genesymbol_syn
DAGK4
resolver
hgnc
HGNC:2856
resolver
uniprot
A0A140VKC1
resolver
uniprot
Q59FF7
resolver
uniprot
Q6P3W4
resolver
uniprot_entry
A0A140VKC1_HUMAN
resolver
uniprot_entry
DGKQ_HUMAN
resolver
uniprot_entry
Q59FF7_HUMAN
resolver
uniprot_sec
Q6P3W4
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphatidylserine. {ECO:0000269|PubMed:11309392}.
uniprot
proteins
amino_acid_sequence
MAAAAEPGARAWLGGGSPRPGSPACSPVLGSGGRARPGPGPGPGPERAGVRAPGPAAAPGHSFRKVTLTKPTFCHLCSDFIWGLAGFLCDVCNFMSHEKCLKHVRIPCTSVAPSLVRVPVAHCFGPRGLHKRKFCAVCRKVLEAPALHCEVCELHLHPDCVPFACSDCRQCHQDGHQDHDTHHHHWREGNLPSGARCEVCRKTCGSSDVLAGVRCEWCGVQAHSLCSAALAPECGFGRLRSLVLPPACVRLLPGGFSKTQSFRIVEAAEPGEGGDGADGSAAVGPGRETQATPESGKQTLKIFDGDDAVRRSQFRLVTVSRLAGAEEVLEAALRAHHIPEDPGHLELCRLPPSSQACDAWAGGKAGSAVISEEGRSPGSGEATPEAWVIRALPRAQEVLKIYPGWLKVGVAYVSVRVTPKSTARSVVLEVLPLLGRQAESPESFQLVEVAMGCRHVQRTMLMDEQPLLDRLQDIRQMSVRQVSQTRFYVAESRDVAPHVSLFVGGLPPGLSPEEYSSLLHEAGATKATVVSVSHIYSSQGAVVLDVACFAEAERLYMLLKDMAVRGRLLTALVLPDLLHAKLPPDSCPLLVFVNPKSGGLKGRDLLCSFRKLLNPHQVFDLTNGGPLPGLHLFSQVPCFRVLVCGGDGTVGWVLGALEETRYRLACPEPSVAILPLGTGNDLGRVLRWGAGYSGEDPFSVLLSVDEADAVLMDRWTILLDAHEAGSAENDTADAEPPKIVQMSNYCGIGIDAELSLDFHQAREEEPGKFTSRLHNKGVYVRVGLQKISHSRSLHKQIRLQVERQEVELPSIEGLIFINIPSWGSGADLWGSDSDTRFEKPRMDDGLLEVVGVTGVVHMGQVQGGLRSGIRIAQGSYFRVTLLKATPVQVDGEPWVQAPGHMIISAAGPKVHMLRKAKQKPRRAGTTRDARADAAPAPESDPR
uniprot
proteins
ec_number
2.7.1.107
uniprot
proteins
ec_number
2.7.1.93
uniprot
proteins
function
FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11309392, PubMed:22627129, PubMed:9099683). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (PubMed:11309392, PubMed:17664281, PubMed:26748701). Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription (PubMed:17664281). Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor (By similarity). Through its diacylglycerol activity also regulates synaptic vesicle endocytosis (PubMed:26748701). {ECO:0000250|UniProtKB:D3ZEY4, ECO:0000269|PubMed:11309392, ECO:0000269|PubMed:17664281, ECO:0000269|PubMed:22627129, ECO:0000269|PubMed:26748701, ECO:0000269|PubMed:9099683}.
uniprot
proteins
mass_dalton
101155
uniprot
proteins
mutagenesis
MUTAGEN 100; /note="C->G: Abolishes translocation to the plasma membrane."; /evidence="ECO:0000269|PubMed:15632189"; MUTAGEN 160; /note="C->G: Abolishes translocation to the plasma membrane."; /evidence="ECO:0000269|PubMed:15632189"; MUTAGEN 226; /note="C->G: Abolishes translocation to the plasma membrane."; /evidence="ECO:0000269|PubMed:15632189"; MUTAGEN 237; /note="G->R: Loss of diacylglycerol kinase activity. No effect on translocation to the plasma membrane."; /evidence="ECO:0000269|PubMed:15164764, ECO:0000269|PubMed:15632189"; MUTAGEN 241; /note="S->T: No effect on diacylglycerol kinase activity."; /evidence="ECO:0000269|PubMed:15164764"; MUTAGEN 242; /note="L->V: No effect on diacylglycerol kinase activity."; /evidence="ECO:0000269|PubMed:15164764"; MUTAGEN 245; /note="P->A,L: Decreased diacylglycerol kinase activity."; /evidence="ECO:0000269|PubMed:15164764"; MUTAGEN 246; /note="P->L: Loss of diacylglycerol kinase activity."; /evidence="ECO:0000269|PubMed:15164764"; MUTAGEN 648; /note="G->A: Loss of diacylglycerol kinase activity. Loss of function is synaptic endocytosis."; /evidence="ECO:0000269|PubMed:15164764, ECO:0000269|PubMed:26748701
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; glycerolipid metabolism. {ECO:0000305|PubMed:9099683}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PRKCE and PRKCH in vitro. {ECO:0000269|PubMed:15632189}.
uniprot
proteins
protein_family
Eukaryotic diacylglycerol kinase family
uniprot
proteins
pubmed
10066731
uniprot
proteins
pubmed
11309392
uniprot
proteins
pubmed
12799190
uniprot
proteins
pubmed
15164764
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15632189
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17664281
uniprot
proteins
pubmed
22627129
uniprot
proteins
pubmed
23949095
uniprot
proteins
pubmed
26748701
uniprot
proteins
pubmed
7607687
uniprot
proteins
pubmed
9099683
uniprot
proteins
sequence_length
942
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15632189}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q6P5E8}. Cell membrane {ECO:0000269|PubMed:10066731, ECO:0000269|PubMed:15632189}. Synapse {ECO:0000250|UniProtKB:Q6P5E8}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10066731}. Nucleus {ECO:0000269|PubMed:12799190}. Nucleus speckle {ECO:0000269|PubMed:12799190}. Nucleus matrix {ECO:0000250|UniProtKB:D3ZEY4}. Note=Translocates to the plasma membrane in response to steroid hormone receptor stimulation (PubMed:15632189). Translocation to the plasma membrane is dependent on G protein-coupled receptor stimulation and subsequent activation of PRKCE and probably PRKCH (PubMed:15632189). Translocates to the nucleus in response to thrombin stimulation (Probable). Association with the nuclear matrix is regulated by nerve growth factor (By similarity). {ECO:0000250|UniProtKB:D3ZEY4, ECO:0000269|PubMed:15632189, ECO:0000305|PubMed:11309392}.
uniprot
proteins