RAB21
entrez
23011
canonical
uniprot
Q9UL25
canonical
ensembl
ENSG00000080371
resolver
ensp
ENSP00000261263
resolver
enst
ENST00000261263
resolver
genesymbol
RAB21
resolver
genesymbol_syn
KIAA0118
resolver
hgnc
HGNC:18263
resolver
uniprot
Q14466
resolver
uniprot
Q569H3
resolver
uniprot_entry
RAB21_HUMAN
resolver
uniprot_sec
Q14466
resolver
uniprot_sec
Q569H3
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) including ANKRD27 and RABGEF1, which promote the exchange of bound GDP for free GTP (PubMed:16525121, PubMed:17450153). Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity (Probable). Inhibited by GDP dissociation inhibitors (GDIs) (Probable). {ECO:0000269|PubMed:16525121, ECO:0000269|PubMed:17450153, ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MAAAGGGGGGAAAAGRAYSFKVVLLGEGCVGKTSLVLRYCENKFNDKHITTLQASFLTKKLNIGGKRVNLAIWDTAGQERFHALGPIYYRDSNGAILVYDITDEDSFQKVKNWVKELRKMLGNEICLCIVGNKIDLEKERHVSIQEAESYAESVGAKHYHTSAKQNKGIEELFLDLCKRMIETAQVDERAKGNGSSQPGTARRGVQIIDDEPQAQTSGGGCCSSG
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:18804435, PubMed:25648148, PubMed:31455601). RAB21 is involved in membrane trafficking control (PubMed:18804435, PubMed:25648148). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (PubMed:18804435). Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity). As a result, may regulate cell adhesion and migration (By similarity). Involved in neurite growth (By similarity). Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148). Modulates protein levels of the cargo receptors TMED2 and TMED10, and required for appropriate Golgi localization of TMED10 (PubMed:31455601). {ECO:0000250|UniProtKB:P35282, ECO:0000250|UniProtKB:Q6AXT5, ECO:0000269|PubMed:18804435, ECO:0000269|PubMed:25648148, ECO:0000269|PubMed:31455601}.
uniprot
proteins
mass_dalton
24348
uniprot
proteins
mutagenesis
MUTAGEN 33; /note="T->N: Defects in GTP-binding. Abolishes the interaction with VAMP8 in response to starvation. Abolishes the interaction with TMED10."; /evidence="ECO:0000269|PubMed:15561770, ECO:0000269|PubMed:25648148, ECO:0000269|PubMed:31455601"; MUTAGEN 78; /note="Q->L: Defects in GTP hydrolysis. Does not affect the interaction with VAMP8 in response to starvation. Does not affect the interaction with TMED10."; /evidence="ECO:0000269|PubMed:15561770, ECO:0000269|PubMed:31455601
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10887961
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15561770
uniprot
proteins
pubmed
16034420
uniprot
proteins
pubmed
16525121
uniprot
proteins
pubmed
17450153
uniprot
proteins
pubmed
18477474
uniprot
proteins
pubmed
18804435
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19745841
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
25648148
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
31455601
uniprot
proteins
pubmed
7788527
uniprot
proteins
sequence_length
225
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10887961}; Lipid-anchor {ECO:0000305}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:19745841}. Golgi apparatus membrane {ECO:0000305}. Early endosome membrane {ECO:0000269|PubMed:16525121, ECO:0000269|PubMed:25648148}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:10887961}. Cleavage furrow {ECO:0000269|PubMed:18804435}. Cell projection, neuron projection {ECO:0000250|UniProtKB:P35282}. Note=Colocalizes with ANKRD27 and VAMP7 in neurites (By similarity). In nonpolarized epithelial Caco-2 cells, found in the endoplasmic reticulum; in polarized cells, observed in vesicles in the apical cytoplasm (PubMed:10887961). During mitosis, in mid-telophase, localized in the ingressing cleavage furrow (PubMed:18804435). In late telophase, detected at the opposite poles of the daughter cells, in vesicles at the base of lamellipodia formed by the separating daughter cells (PubMed:18804435). {ECO:0000250|UniProtKB:P35282, ECO:0000269|PubMed:10887961, ECO:0000269|PubMed:18804435}.
uniprot
proteins