DMBT1
entrez
1755
canonical
uniprot
Q9UGM3
canonical
ensembl
ENSG00000187908
resolver
ensp
ENSP00000342210
resolver
ensp
ENSP00000357905
resolver
ensp
ENSP00000357951
resolver
ensp
ENSP00000357952
resolver
ensp
ENSP00000499304
resolver
enst
ENST00000666315
resolver
genesymbol
DMBT1
resolver
genesymbol_syn
GP340
resolver
hgnc
HGNC:2926
resolver
uniprot
A0A590UJ76
resolver
uniprot
A6NDG4
resolver
uniprot
A6NDJ5
resolver
uniprot
A8E4R5
resolver
uniprot
B1ARE7
resolver
uniprot
B1ARE8
resolver
uniprot
B1ARE9
resolver
uniprot
B1ARF0
resolver
uniprot
B7Z8Y2
resolver
uniprot
F8WEF7
resolver
uniprot
Q59EX0
resolver
uniprot
Q5JR26
resolver
uniprot
Q6MZN4
resolver
uniprot
Q96DU4
resolver
uniprot
Q9UGM2
resolver
uniprot
Q9UJ57
resolver
uniprot
Q9UKJ4
resolver
uniprot
Q9Y211
resolver
uniprot
Q9Y4V9
resolver
uniprot_entry
A0A590UJ76_HUMAN
resolver
uniprot_entry
DMBT1_HUMAN
resolver
uniprot_sec
A6NDG4
resolver
uniprot_sec
A6NDJ5
resolver
uniprot_sec
A8E4R5
resolver
uniprot_sec
B1ARE7
resolver
uniprot_sec
B1ARE8
resolver
uniprot_sec
B1ARE9
resolver
uniprot_sec
B1ARF0
resolver
uniprot_sec
B7Z8Y2
resolver
uniprot_sec
F8WEF7
resolver
uniprot_sec
Q59EX0
resolver
uniprot_sec
Q5JR26
resolver
uniprot_sec
Q6MZN4
resolver
uniprot_sec
Q96DU4
resolver
uniprot_sec
Q9UGM2
resolver
uniprot_sec
Q9UJ57
resolver
uniprot_sec
Q9UKJ4
resolver
uniprot_sec
Q9Y211
resolver
uniprot_sec
Q9Y4V9
resolver
amino_acid_sequence
MGISTVILEMCLLWGQVLSTGGWIPRTTDYASLIPSEVPLDPTVAEGSPFPSESTLESTVAEGSPISLESTLESTVAEGSLIPSESTLESTVAEGSDSGLALRLVNGDGRCQGRVEILYRGSWGTVCDDSWDTNDANVVCRQLGCGWAMSAPGNAWFGQGSGPIALDDVRCSGHESYLWSCPHNGWLSHNCGHGEDAGVICSAAQPQSTLRPESWPVRISPPVPTEGSESSLALRLVNGGDRCRGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNAQFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLTHNCGHSEDAGVICSAPQSRPTPSPDTWPTSHASTAGPESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDSWDTSDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGYESYLWSCPHNGWLSHNCQHSEDAGVICSAAHSWSTPSPDTLPTITLPASTVGSESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWAMLAPGNARFGQGSGPIVLDDVRCSGNESYLWSCPHNGWLSHNCGHSEDAGVICSGPESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWSCPNNGWLSHNCGHHEDAGVICSAAQSRSTPRPDTLSTITLPPSTVGSESSLTLRLVNGSDRCQGRVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLSHNCGHHEDAGVICSVSQSRPTPSPDTWPTSHASTAGPESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDSWDTSDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGYESYLWSCPHNGWLSHNCQHSEDAGVICSAAHSWSTPSPDTLPTITLPASTVGSESSLALRLVNGGDRCQGRVEVLYQGSWGTVCDDSWDTNDANVVCRQLGCGWAMSAPGNARFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLSHNCGHSEDAGVICSASQSRPTPSPDTWPTSHASTAGSESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNARFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLSHNCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLSHNCGHHEDAGVICSASQSQPTPSPDTWPTSHASTAGSESSLALRLVNGGDRCQGRVEVLYRGSWGTVCDDYWDTNDANVVCRQLGCGWATSAPGNARFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLSHNCGHHEDAGVICSASQSQPTPSPDTWPTSRASTAGSESTLALRLVNGGDRCRGRVEVLYQGSWGTVCDDYWDTNDANVVCRQLGCGWAMSAPGNAQFGQGSGPIVLDDVRCSGHESYLWSCPHNGWLSHNCGHHEDAGVICSAAQSQSTPRPDTWLTTNLPALTVGSESSLALRLVNGGDRCRGRVEVLYRGSWGTVCDDSWDTNDANVVCRQLGCGWAMSAPGNARFGQGSGPIVLDDVRCSGNESYLWSCPHKGWLTHNCGHHEDAGVICSATQINSTTTDWWHPTTTTTARPSSNCGGFLFYASGTFSSPSYPAYYPNNAKCVWEIEVNSGYRINLGFSNLKLEAHHNCSFDYVEIFDGSLNSSLLLGKICNDTRQIFTSSYNRMTIHFRSDISFQNTGFLAWYNSFPSDATLRLVNLNSSYGLCAGRVEIYHGGTWGTVCDDSWTIQEAEVVCRQLGCGRAVSALGNAYFGSGSGPITLDDVECSGTESTLWQCRNRGWFSHNCNHREDAGVICSGNHLSTPAPFLNITRPNTDYSCGGFLSQPSGDFSSPFYPGNYPNNAKCVWDIEVQNNYRVTVIFRDVQLEGGCNYDYIEVFDGPYRSSPLIARVCDGARGSFTSSSNFMSIRFISDHSITRRGFRAEYYSSPSNDSTNLLCLPNHMQASVSRSYLQSLGFSASDLVISTWNGYYECRPQITPNLVIFTIPYSGCGTFKQADNDTIDYSNFLTAAVSGGIIKRRTDLRIHVSCRMLQNTWVDTMYIANDTIHVANNTIQVEEVQYGNFDVNISFYTSSSFLYPVTSRPYYVDLNQDLYVQAEILHSDAVLTLFVDTCVASPYSNDFTSLTYDLIRSGCVRDDTYGPYSSPSLRIARFRFRAFHFLNRFPSVYLRCKMVVCRAYDPSSRCYRGCVLRSKRDVGSYQEKVDVVLGPIQLQTPPRREEEPR
uniprot
proteins
disease_involvement
DISEASE: Glioma (GLM) [MIM:137800]: Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes. Note=The gene represented in this entry is involved in disease pathogenesis. Homozygous deletions may be the predominant mechanism of DMBT1 inactivation playing a role in carcinogenesis. DMBT1 is deleted in medulloblastoma and glioblastoma cell lines; point mutations have also been reported in patients with glioma. A loss or reduction of DMBT1 expression has been seen in esophageal, gastric, lung and colorectal carcinomas as well.
uniprot
proteins
function
FUNCTION: May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell. {ECO:0000269|PubMed:10485905, ECO:0000269|PubMed:11007786, ECO:0000269|PubMed:11751412, ECO:0000269|PubMed:16796526, ECO:0000269|PubMed:17548659, ECO:0000269|PubMed:17709527, ECO:0000269|PubMed:19189310, ECO:0000269|PubMed:9288095}.
uniprot
proteins
mass_dalton
260735
uniprot
proteins
post_translational_modification
PTM: Highly N- and O-glycosylated. The O-glycans are heavily sulfated (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
DMBT1 family
uniprot
proteins
pubmed
10101009
uniprot
proteins
pubmed
10485905
uniprot
proteins
pubmed
10551316
uniprot
proteins
pubmed
10597221
uniprot
proteins
pubmed
10749143
uniprot
proteins
pubmed
11007786
uniprot
proteins
pubmed
11751412
uniprot
proteins
pubmed
12185598
uniprot
proteins
pubmed
12353266
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15355985
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16740002
uniprot
proteins
pubmed
16796526
uniprot
proteins
pubmed
17548659
uniprot
proteins
pubmed
17709527
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
17983803
uniprot
proteins
pubmed
18713006
uniprot
proteins
pubmed
19189310
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23439307
uniprot
proteins
pubmed
25946035
uniprot
proteins
pubmed
28397838
uniprot
proteins
pubmed
9153228
uniprot
proteins
pubmed
9288095
uniprot
proteins
pubmed
9888459
uniprot
proteins
sequence_length
2413
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Note=Some isoforms may be membrane-bound. Localized to the lumenal aspect of crypt cells in the small intestine. In the colon, seen in the lumenal aspect of surface epithelial cells. Formed in the ducts of von Ebner gland, and released into the fluid bathing the taste buds contained in the taste papillae (By similarity). {ECO:0000250}.
uniprot
proteins