Kcnj2
entrez
29712
canonical
uniprot
Q64273
canonical
ensembl
ENSRNOG00000064933
resolver
ensembl
ENSRNOG00055030394
resolver
ensembl
ENSRNOG00060029515
resolver
ensembl
ENSRNOG00065020965
resolver
ensp
ENSRNOP00000079758
resolver
ensp
ENSRNOP00000108601
resolver
ensp
ENSRNOP00000109976
resolver
ensp
ENSRNOP00000110101
resolver
ensp
ENSRNOP00000111037
resolver
ensp
ENSRNOP00055043588
resolver
ensp
ENSRNOP00060042613
resolver
ensp
ENSRNOP00065028699
resolver
enst
ENSRNOT00000102334
resolver
enst
ENSRNOT00000133616
resolver
enst
ENSRNOT00000135330
resolver
enst
ENSRNOT00000136217
resolver
enst
ENSRNOT00000144045
resolver
enst
ENSRNOT00055052728
resolver
enst
ENSRNOT00060051222
resolver
enst
ENSRNOT00065035600
resolver
genesymbol
Kcnj2
resolver
genesymbol_syn
Irk1
resolver
uniprot_entry
KCNJ2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphatidylinositol 4,5 biphosphate (PtdIns(4,5)P2). {ECO:0000269|PubMed:9486652}.
uniprot
proteins
amino_acid_sequence
MGSVRTNRYSIVSSEEDGMKLATMAVANGFGNGKSKVHTRQQCRSRFVKKDGHCNVQFINVGEKGQRYLADIFTTCVDIRWRWMLVIFCLAFVLSWLFFGCVFWLIALLHGDLDASKESKACVSEVNSFTAAFLFSIETQTTIGYGFRCVTDECPIAVFMVVFQSIVGCIIDAFIIGAVMAKMAKPKKRNETLVFSHNAVIAMRDGKLCLMWRVGNLRKSHLVEAHVRAQLLKSRITSEGEYIPLDQIDINVGFDSGIDRIFLVSPITIVHEIDEDSPLYDLSKQDIDNADFEIVVILEGMVEATAMTTQCRSSYLANEILWGHRYEPVLFEEKHCYKVDYSRFHKTYEVPNTPLCSARDLAEKKYILSNANSFCYENEVALTSKEEEDSENGVPESTSTDSPPGIDLHNQASVPLEPRPLRRESEI
uniprot
proteins
function
FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (PubMed:7603835, PubMed:9486652). Can be blocked by extracellular barium and cesium. Probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues (By similarity). {ECO:0000250|UniProtKB:P63252, ECO:0000269|PubMed:7603835, ECO:0000269|PubMed:9486652}.
uniprot
proteins
mass_dalton
48200
uniprot
proteins
post_translational_modification
PTM: S-nitrosylation increases the open probability and inward rectifying currents. {ECO:0000250|UniProtKB:P63252}.
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ2 subfamily
uniprot
proteins
pubmed
14960569
uniprot
proteins
pubmed
21209095
uniprot
proteins
pubmed
7603835
uniprot
proteins
pubmed
9486652
uniprot
proteins
pubmed
9533862
uniprot
proteins
sequence_length
427
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21209095}; Multi-pass membrane protein {ECO:0000255}. Cell membrane, sarcolemma, T-tubule {ECO:0000269|PubMed:21209095}.
uniprot
proteins
transmembrane_region
TRANSMEM 82..106; /note="Helical; Name=M1"; /evidence="ECO:0000250"; TRANSMEM 157..178; /note="Helical; Name=M2"; /evidence="ECO:0000250
uniprot
proteins