NUB1
entrez
51667
canonical
uniprot
Q9Y5A7
canonical
ensembl
ENSG00000013374
resolver
ensp
ENSP00000398644
resolver
ensp
ENSP00000418234
resolver
ensp
ENSP00000454264
resolver
ensp
ENSP00000536459
resolver
ensp
ENSP00000536460
resolver
ensp
ENSP00000536464
resolver
ensp
ENSP00000536465
resolver
ensp
ENSP00000536466
resolver
ensp
ENSP00000584468
resolver
enst
ENST00000413040
resolver
enst
ENST00000568733
resolver
genesymbol
NUB1
resolver
genesymbol_syn
NYREN18
resolver
hgnc
HGNC:17623
resolver
uniprot
H3BM14
resolver
uniprot
H3BM74
resolver
uniprot
O95422
resolver
uniprot
Q75MR9
resolver
uniprot
Q8IX22
resolver
uniprot
Q9BXR2
resolver
uniprot_entry
H3BM14_HUMAN
resolver
uniprot_entry
H3BM74_HUMAN
resolver
uniprot_entry
NUB1_HUMAN
resolver
uniprot_sec
O95422
resolver
uniprot_sec
Q75MR9
resolver
uniprot_sec
Q8IX22
resolver
uniprot_sec
Q9BXR2
resolver
amino_acid_sequence
MAQKKYLQAKLTQFLREDRIQLWKPPYTDENKKVGLALKDLAKQYSDRLECCENEVEKVIEEIRCKAIERGTGNDNYRTTGIATIEVFLPPRLKKDRKNLLETRLHITGRELRSKIAETFGLQENYIKIVINKKQLQLGKTLEEQGVAHNVKAMVLELKQSEEDARKNFQLEEEEQNEAKLKEKQIQRTKRGLEILAKRAAETVVDPEMTPYLDIANQTGRSIRIPPSERKALMLAMGYHEKGRAFLKRKEYGIALPCLLDADKYFCECCRELLDTVDNYAVLQLDIVWCYFRLEQLECLDDAEKKLNLAQKCFKNCYGENHQRLVHIKGNCGKEKVLFLRLYLLQGIRNYHSGNDVEAYEYLNKARQLFKELYIDPSKVDNLLQLGFTAQEARLGLRACDGNVDHAATHITNRREELAQIRKEEKEKKRRRLENIRFLKGMGYSTHAAQQVLHAASGNLDEALKILLSNPQMWWLNDSNPETDNRQESPSQENIDRLVYMGFDALVAEAALRVFRGNVQLAAQTLAHNGGSLPPELPLSPEDSLSPPATSPSDSAGTSSASTDEDMETEAVNEILEDIPEHEEDYLDSTLEDEEIIIAEYLSYVENRKSATKKN
uniprot
proteins
function
FUNCTION: Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation. Isoform 1 promotes the degradation of NEDD8 more efficiently than isoform 2. {ECO:0000269|PubMed:16707496}.
uniprot
proteins
mass_dalton
70538
uniprot
proteins
mutagenesis
MUTAGEN 448; /note="A->V: No effect on NEDD8-binding."; /evidence="ECO:0000269|PubMed:12816948"; MUTAGEN 453; /note="L->A: Partial inhibition of NEDD8-binding."; /evidence="ECO:0000269|PubMed:12816948"; MUTAGEN 464; /note="L->A: Partial inhibition of NEDD8-binding."; /evidence="ECO:0000269|PubMed:12816948"; MUTAGEN 468; /note="L->A: Partial inhibition of NEDD8-binding."; /evidence="ECO:0000269|PubMed:12816948"; MUTAGEN 587; /note="L->A: Suppression of NEDD8-binding; when associated with A-464; A-468 and A-591. Suppression of NEDD8-buster function; when associated with A-591."; /evidence="ECO:0000269|PubMed:12816948"; MUTAGEN 591; /note="L->A: Suppression of NEDD8-binding; when associated with A-464; A-468 and A-587. Suppression of NEDD8-buster function; when associated with A-587."; /evidence="ECO:0000269|PubMed:12816948
uniprot
proteins
pubmed
10508479
uniprot
proteins
pubmed
11259415
uniprot
proteins
pubmed
11585840
uniprot
proteins
pubmed
12374762
uniprot
proteins
pubmed
12816948
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14757770
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16707496
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25422469
uniprot
proteins
sequence_length
615
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11259415}. Note=Predominantly nuclear.
uniprot
proteins