NDOR1
entrez
27158
canonical
uniprot
Q9UHB4
canonical
ensembl
ENSG00000188566
resolver
ensp
ENSP00000360576
resolver
ensp
ENSP00000389905
resolver
ensp
ENSP00000394309
resolver
ensp
ENSP00000507194
resolver
genesymbol
NDOR1
resolver
genesymbol_syn
NR1
resolver
hgnc
HGNC:29838
resolver
uniprot
D3YTG6
resolver
uniprot
D3YTH9
resolver
uniprot
Q5VSG4
resolver
uniprot
Q86US9
resolver
uniprot
Q96BC6
resolver
uniprot_entry
NDOR1_HUMAN
resolver
uniprot_sec
D3YTG6
resolver
uniprot_sec
D3YTH9
resolver
uniprot_sec
Q5VSG4
resolver
uniprot_sec
Q86US9
resolver
uniprot_sec
Q96BC6
resolver
amino_acid_sequence
MPSPQLLVLFGSQTGTAQDVSERLGREARRRRLGCRVQALDSYPVVNLINEPLVIFVCATTGQGDPPDNMKNFWRFIFRKNLPSTALCQMDFAVLGLGDSSYAKFNFVAKKLHRRLLQLGGSALLPVCLGDDQHELGPDAAVDPWLRDLWDRVLGLYPPPPGLTEIPPGVPLPSKFTLLFLQEAPSTGSEGQRVAHPGSQEPPSESKPFLAPMISNQRVTGPSHFQDVRLIEFDILGSGISFAAGDVVLIQPSNSAAHVQRFCQVLGLDPDQLFMLQPREPDVSSPTRLPQPCSMRHLVSHYLDIASVPRRSFFELLACLSLHELEREKLLEFSSAQGQEELFEYCNRPRRTILEVLCDFPHTAAAIPPDYLLDLIPVIRPRAFSIASSLLTHPSRLQILVAVVQFQTRLKEPRRGLCSSWLASLDPGQGPVRVPLWVRPGSLAFPETPDTPVIMVGPGTGVAPFRAAIQERVAQGQTGNFLFFGCRWRDQDFYWEAEWQELEKRDCLTLIPAFSREQEQKVYVQHRLRELGSLVWELLDRQGAYFYLAGNAKSMPADVSEALMSIFQEEGGLCSPDAAAYLARLQQTRRFQTETWA
uniprot
proteins
ec_number
1.18.1.-
uniprot
proteins
function
FUNCTION: NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery (PubMed:10625700, PubMed:15900210, PubMed:20802492, PubMed:23596212, PubMed:28648056). Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery (PubMed:20802492, PubMed:23596212, PubMed:28648056). In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins (PubMed:20802492, PubMed:23596212). It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair (PubMed:28648056). In vitro can fully activate methionine synthase/MTR in the presence of soluble cytochrome b5/CYB5A (PubMed:12871938). {ECO:0000255|HAMAP-Rule:MF_03178, ECO:0000269|PubMed:10625700, ECO:0000269|PubMed:12871938, ECO:0000269|PubMed:15900210, ECO:0000269|PubMed:20802492, ECO:0000269|PubMed:23596212, ECO:0000269|PubMed:28648056}.
uniprot
proteins
mass_dalton
66763
uniprot
proteins
protein_family
NADPH-dependent diflavin oxidoreductase NDOR1 family; Flavodoxin family; Flavoprotein pyridine nucleotide cytochrome reductase family
uniprot
proteins
pubmed
10625700
uniprot
proteins
pubmed
12631275
uniprot
proteins
pubmed
12871938
uniprot
proteins
pubmed
12871939
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15900210
uniprot
proteins
pubmed
16140270
uniprot
proteins
pubmed
20802492
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23596212
uniprot
proteins
pubmed
28648056
uniprot
proteins
sequence_length
597
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000255|HAMAP-Rule:MF_03178, ECO:0000269|PubMed:10625700, ECO:0000269|PubMed:12871939}. Note=Concentrated in perinuclear structure. {ECO:0000255|HAMAP-Rule:MF_03178, ECO:0000269|PubMed:12871939}.
uniprot
proteins