Ldb1
entrez
16825
canonical
uniprot
P70662
canonical
ensembl
ENSMUSG00000025223
resolver
ensp
ENSMUSP00000026252
resolver
ensp
ENSMUSP00000053680
resolver
ensp
ENSMUSP00000116909
resolver
ensp
ENSMUSP00000139562
resolver
enst
ENSMUST00000152946
resolver
genesymbol
Ldb1
resolver
genesymbol_syn
Nli
resolver
uniprot
D3Z1C5
resolver
uniprot
O55204
resolver
uniprot
Q1EQX2
resolver
uniprot
Q71V68
resolver
uniprot_entry
D3Z1C5_MOUSE
resolver
uniprot_entry
LDB1_MOUSE
resolver
uniprot_sec
O55204
resolver
uniprot_sec
Q1EQX2
resolver
uniprot_sec
Q71V68
resolver
amino_acid_sequence
MSVGCACPGCSSKSFKLYSPKEPPNGNAFPPFHPGTMLDRDVGPTPMYPPTYLEPGIGRHTPYGNQTDYRIFELNKRLQNWTEECDNLWWDAFTTEFFEDDAMLTITFCLEDGPKRYTIGRTLIPRYFRSIFEGGATELYYVLKHPKEAFHSNFVSLDCDQGSMVTQHGKPMFTQVCVEGRLYLEFMFDDMMRIKTWHFSIRQHRELIPRSILAMHAQDPQMLDQLSKNITRCGLSNSTLNYLRLCVILEPMQELMSRHKTYSLSPRDCLKTCLFQKWQRMVAPPAEPARQQPSKRRKRKMSGGSTMSSGGGNTNNSNSKKKSPASTFALSSQVPDVMVVGEPTLMGGEFGDEDERLITRLENTQFDAANGIDDEDSFNNSPALGANSPWNSKPPSSQESKSENPTSQASQ
uniprot
proteins
function
FUNCTION: Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors (PubMed:8918878, PubMed:9192866). May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions (PubMed:16815859, PubMed:18539116, PubMed:8918878, PubMed:9192866, PubMed:9315627). Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1 (PubMed:12150931, PubMed:18539116, PubMed:8876198). Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression (PubMed:8918878). Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (PubMed:9391090). {ECO:0000269|PubMed:12150931, ECO:0000269|PubMed:16815859, ECO:0000269|PubMed:18539116, ECO:0000269|PubMed:8876198, ECO:0000269|PubMed:8918878, ECO:0000269|PubMed:9192866, ECO:0000269|PubMed:9315627, ECO:0000269|PubMed:9391090}.
uniprot
proteins
mass_dalton
46503
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by RLIM/RNF12, leading to its degradation by the proteasome. {ECO:0000269|PubMed:11882901}.
uniprot
proteins
protein_family
LDB family
uniprot
proteins
pubmed
10330499
uniprot
proteins
pubmed
10393337
uniprot
proteins
pubmed
11882901
uniprot
proteins
pubmed
12150931
uniprot
proteins
pubmed
12727888
uniprot
proteins
pubmed
15343268
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16407974
uniprot
proteins
pubmed
16815859
uniprot
proteins
pubmed
18539116
uniprot
proteins
pubmed
19675209
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23353824
uniprot
proteins
pubmed
8876198
uniprot
proteins
pubmed
8918878
uniprot
proteins
pubmed
9192866
uniprot
proteins
pubmed
9315627
uniprot
proteins
pubmed
9391090
uniprot
proteins
pubmed
9468533
uniprot
proteins
pubmed
9503020
uniprot
proteins
pubmed
9860983
uniprot
proteins
sequence_length
411
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8876198, ECO:0000269|PubMed:9315627, ECO:0000269|PubMed:9391090}. Note=Colocalizes with SLK at leading edges (PubMed:19675209). {ECO:0000269|PubMed:19675209}.
uniprot
proteins