Cxcl17
entrez
232983
canonical
uniprot
Q5UW37
canonical
ensembl
ENSMUSG00000060188
resolver
ensp
ENSMUSP00000144096
resolver
enst
ENSMUST00000200880
resolver
genesymbol
Cxcl17
resolver
genesymbol_syn
Vcc1
resolver
uniprot_entry
CXL17_MOUSE
resolver
amino_acid_sequence
MKLLASPFLLLLPVMLMSMVFSSPNPGVARSHGDQHLAPRRWLLEGGQECECKDWFLQAPKRKATAVLGPPRKQCPCDHVKGREKKNRHQKHHRKSQRPSRACQQFLKRCHLASFALPL
uniprot
proteins
function
FUNCTION: Chemokine that acts as a chemoattractant for monocytes, macrophages and dendritic cells, and which is involved in immune regulation and lymphocyte trafficking (PubMed:24973458, PubMed:38298146). Activates the C-X-C chemokine receptor GPR25 (By similarity). Plays a key role in lymphocyte homing by activating the receptor GPR25 on lymphocytes, mediating lymphocyte recruitment into the respiratory, upper gastrointestinal, biliary and genito-urinary tracts (By similarity). Plays a role in angiogenesis and possibly in the development of tumors (PubMed:16989774). Acts as an anti-inflammatory in the stomach. May play a role in the innate defense against infections (By similarity). {ECO:0000250|UniProtKB:Q6UXB2, ECO:0000269|PubMed:16989774, ECO:0000269|PubMed:24973458, ECO:0000269|PubMed:38298146}.; FUNCTION: [4-Cys CXCL17]: Seems to exhibit much higher chemoattractant potency on monocytes and macrophages than 6-Cys CXCL17. {ECO:0000250|UniProtKB:Q6UXB2}.
uniprot
proteins
mass_dalton
13627
uniprot
proteins
post_translational_modification
PTM: Likely to undergo an endoproteolytic process to form a four-cysteine-containing mature peptide with a canonical CXC chemokine scaffold after secretion. {ECO:0000250|UniProtKB:D4A875}.
uniprot
proteins
protein_family
Intercrine alpha (chemokine CxC) family
uniprot
proteins
pubmed
16989774
uniprot
proteins
pubmed
24973458
uniprot
proteins
pubmed
30860634
uniprot
proteins
pubmed
38298146
uniprot
proteins
sequence_length
119
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q6UXB2}.
uniprot
proteins