Ttc1
entrez
66827
canonical
uniprot
Q91Z38
canonical
ensembl
ENSMUSG00000041278
resolver
ensp
ENSMUSP00000040779
resolver
enst
ENSMUST00000048578
resolver
genesymbol
Ttc1
resolver
uniprot
Q3TLM0
resolver
uniprot_entry
TTC1_MOUSE
resolver
uniprot_sec
Q3TLM0
resolver
amino_acid_sequence
MEEKSEDCKVPEDLFNGLKVADPQEGESASPMVSDPKGQHCQSKLPKAAEAHPQDDHVEEECFHDCSASFEEEQPGAHVAGSKASDDSSSELDEEYLIELEKNMPEEEKQKRREESAKLKEEGNERFKRGDYMEAESSYSQALQMCPACFQKDRSVLFSNRAAARMKQDKKETAITDCSKAIQLNPTYIRAILRRAELYEKTDKLDEALEDYKSVLEKDPSVHQAREACMRLPKQIEERNERLKEEMLGKLKDLGNLVLRPFGLSTENFQIKQDSSTGSYSINFVQNPNNNR
uniprot
proteins
function
FUNCTION: Adapter protein that plays a role downstream of GNA15 to stimulate Ras activation and subsequent phosphorylation of ERK1/2 independently of phospholipase Cbeta signaling. Mechanistically, interacts with GNA15 and SOS2 to form a macromolecular signaling complex which has a high affinity for HRAS. Additionally, participates in signaling via other G-alpha proteins like GNA14, activating NF-kappa-B through Ras and ERK pathways. Beyond signaling, supports protein homeostasis by cooperating with HSP40 in the HSP70 chaperone cycle, promoting protein folding through the regulated dissociation of the HSP70 inhibitor HSPBP1. {ECO:0000250|UniProtKB:Q99614}.
uniprot
proteins
mass_dalton
33263
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
292
uniprot
proteins