Chtop
entrez
361990
canonical
uniprot
Q498T2
canonical
ensembl
ENSRNOG00000012760
resolver
ensp
ENSRNOP00000010455
resolver
ensp
ENSRNOP00000017561
resolver
ensp
ENSRNOP00000102443
resolver
enst
ENSRNOT00000137072
resolver
genesymbol
Chtop
resolver
genesymbol_syn
Fop
resolver
uniprot
A0ABK0LLY2
resolver
uniprot
Q66H75
resolver
uniprot_entry
A0ABK0LLY2_RAT
resolver
uniprot_entry
CHTOP_RAT
resolver
uniprot_sec
Q66H75
resolver
amino_acid_sequence
MAAQSAPKVVLKSTTKMSLNERFTNMLKNKQPMPVNIWASMQQQQQLASARNRRLAQQMENRPSVQAALKLKQSLKQRLGKSNIQARLGRPIGALARGAIGGRSLPIIQRGLPRGGLRGGRATRTLLRGGMSLRGQNLLRGGRAVAPRMGLRRGGVRGRGGPGRGGLGRGAMGRGGIGGRGRGMIGRGRGGFGGRGRGRGRGRGALTRPVLTKEQLDNQLDAYMSKTKGHLDAELDAYMAQTDPETND
uniprot
proteins
function
FUNCTION: Plays an important role in the ligand-dependent activation of estrogen receptor target genes. May play a role in the silencing of fetal globin genes. Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Required for the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC methylates H4R3 and transactivates genes involved in glioblastomagenesis (By similarity). {ECO:0000250|UniProtKB:Q9CY57, ECO:0000250|UniProtKB:Q9Y3Y2}.
uniprot
proteins
mass_dalton
26517
uniprot
proteins
post_translational_modification
PTM: Asymmetrically methylated by PRMT1. Symmetrically methylated by PRMT5 (By similarity). {ECO:0000250|UniProtKB:Q9CY57}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
248
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y3Y2}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9Y3Y2}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9Y3Y2}. Nucleus speckle {ECO:0000250|UniProtKB:Q9Y3Y2}. Note=Mostly associated with facultative heterochromatin (By similarity). Localizes to regions surrounding nuclear speckles known as perispeckles in which TREX complex assembly seems to occur (By similarity). {ECO:0000250|UniProtKB:Q9CY57, ECO:0000250|UniProtKB:Q9Y3Y2}.
uniprot
proteins