Tspo
entrez
12257
canonical
uniprot
P50637
canonical
ensembl
ENSMUSG00000041736
resolver
ensp
ENSMUSP00000037039
resolver
enst
ENSMUST00000047419
resolver
genesymbol
Tspo
resolver
genesymbol_syn
Bzrp
resolver
genesymbol_syn
Mbr
resolver
uniprot
Q541E3
resolver
uniprot
Q62118
resolver
uniprot
Q6LCZ0
resolver
uniprot
Q99M32
resolver
uniprot_entry
TSPO_MOUSE
resolver
uniprot_sec
Q541E3
resolver
uniprot_sec
Q62118
resolver
uniprot_sec
Q6LCZ0
resolver
uniprot_sec
Q99M32
resolver
amino_acid_sequence
MPESWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIVWKELGGFTEDAMVPLGLYTGQLALNWAWPPIFFGARQMGWALADLLLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATVLNYYVWRDNSGRRGGSRLPE
uniprot
proteins
function
FUNCTION: Can bind protoporphyrin IX and may play a role in the transport of porphyrins and heme (By similarity). Was initially identified as peripheral-type benzodiazepine receptor; can also bind isoquinoline carboxamides. Promotes the transport of cholesterol across mitochondrial membranes and may play a role in lipid metabolism (PubMed:9832438, PubMed:24814875), but its precise physiological role is controversial. According to some reports, it is not required for steroid hormone biosynthesis (PubMed:24174323, PubMed:24936060). {ECO:0000250, ECO:0000269|PubMed:24174323, ECO:0000269|PubMed:24814875, ECO:0000269|PubMed:24936060, ECO:0000269|PubMed:8114671, ECO:0000269|PubMed:9832438}.
uniprot
proteins
mass_dalton
18841
uniprot
proteins
mutagenesis
MUTAGEN 147; /note="A->T: No effect."; /evidence="ECO:0000269|PubMed:25974690"; MUTAGEN 153; /note="Y->S: Abolishes cholesterol transport."; /evidence="ECO:0000269|PubMed:9832438"; MUTAGEN 156; /note="R->L: Abolishes cholesterol transport."; /evidence="ECO:0000269|PubMed:9832438
uniprot
proteins
protein_family
TspO/BZRP family
uniprot
proteins
pubmed
11471062
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24174323
uniprot
proteins
pubmed
24653034
uniprot
proteins
pubmed
24814875
uniprot
proteins
pubmed
24936060
uniprot
proteins
pubmed
25974690
uniprot
proteins
pubmed
7721091
uniprot
proteins
pubmed
8114671
uniprot
proteins
pubmed
8125973
uniprot
proteins
pubmed
9832438
uniprot
proteins
sequence_length
169
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 6..26; /note="Helical; Name=1"; TRANSMEM 47..67; /note="Helical; Name=2"; TRANSMEM 80..100; /note="Helical; Name=3"; TRANSMEM 106..126; /note="Helical; Name=4"; TRANSMEM 135..155; /note="Helical; Name=5
uniprot
proteins