SFRP1
entrez
6422
canonical
uniprot
Q8N474
canonical
ensembl
ENSG00000104332
resolver
ensp
ENSP00000220772
resolver
enst
ENST00000220772
resolver
genesymbol
SFRP1
resolver
genesymbol_syn
FRP
resolver
genesymbol_syn
FRP1
resolver
genesymbol_syn
SARP2
resolver
hgnc
HGNC:10776
resolver
uniprot
O00546
resolver
uniprot
O14779
resolver
uniprot_entry
SFRP1_HUMAN
resolver
uniprot_sec
O00546
resolver
uniprot_sec
O14779
resolver
amino_acid_sequence
MGIGRSEGGRRGAALGVLLALGAALLAVGSASEYDYVSFQSDIGPYQSGRFYTKPPQCVDIPADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASKPQGTTVCPPCDNELKSEAIIEHLCASEFALRMKIKEVKKENGDKKIVPKKKKPLKLGPIKKKDLKKLVLYLKNGADCPCHQLDNLSHHFLIMGRKVKSQYLLTAIHKWDKKNKEFKNFMKKMKNHECPTFQSVFK
uniprot
proteins
function
FUNCTION: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels (By similarity). Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase (By similarity). In kidney development, inhibits tubule formation and bud growth in metanephroi (By similarity). Inhibits WNT1/WNT4-mediated TCF-dependent transcription. {ECO:0000250}.
uniprot
proteins
mass_dalton
35386
uniprot
proteins
mutagenesis
MUTAGEN 173; /note="N->Q: Reduced molecular weight."; /evidence="ECO:0000269|PubMed:11741940"; MUTAGEN 263; /note="N->Q: No effect on molecular weight."; /evidence="ECO:0000269|PubMed:11741940
uniprot
proteins
protein_family
Secreted frizzled-related protein (sFRP) family
uniprot
proteins
pubmed
10347172
uniprot
proteins
pubmed
11741940
uniprot
proteins
pubmed
11932307
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9192640
uniprot
proteins
pubmed
9391078
uniprot
proteins
pubmed
9724099
uniprot
proteins
sequence_length
314
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted. Note=Cell membrane or extracellular matrix-associated. Released by heparin-binding.
uniprot
proteins