Hif3a
entrez
53417
canonical
uniprot
Q0VBL6
canonical
ensembl
ENSMUSG00000004328
resolver
ensp
ENSMUSP00000048248
resolver
ensp
ENSMUSP00000104132
resolver
genesymbol
Hif3a
resolver
genesymbol_syn
Mop7
resolver
genesymbol_syn
Nepas
resolver
uniprot
A1IM61
resolver
uniprot
E9QLB1
resolver
uniprot
Q3UN40
resolver
uniprot
Q8VHR1
resolver
uniprot
Q9QX54
resolver
uniprot
Q9Z2I5
resolver
uniprot_entry
HIF3A_MOUSE
resolver
uniprot_sec
A1IM61
resolver
uniprot_sec
E9QLB1
resolver
uniprot_sec
Q3UN40
resolver
uniprot_sec
Q8VHR1
resolver
uniprot_sec
Q9QX54
resolver
uniprot_sec
Q9Z2I5
resolver
amino_acid_sequence
MDWDQDRSNTELRKEKSRDAARSRRSQETEVLYQLAHTLPFARGVSAHLDKASIMRLTISYLRMHRLCAAGEWNQVEKGGEPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDALTPRPNLSKKKLEAPTERHFSLRMKSTLTSRGRTLNLKAATWKVLHCSGHMRAYKPPAQTSPAGSPRSEPPLQCLVLICEAIPHPASLEPPLGRGAFLSRHSLDMKFTYCDERIAEVAGYSPDDLIGCSAYEYIHALDSDAVSRSIHTLLSKGQAVTGQYRFLARTGGYLWTQTQATVVSGGRGPQSESIICVHFLISRVEETGVVLSLEQTEQHTRRPPRLSASSQKGIPGNSVDSPAPRILAFLHPPALSEASLAADPRRFCSPDLRRLMAPILDGPPPAATPSTPQATRRPQSPLPADLPDKLTVGLENAHRLSTAQKNKTVETDLDIAQDPDTLDLEMLAPYISMDDDFQLNSSEQLPKVHRRPPRVARRPRARSFHGLSPPIPEPSLLPRWGSDPRLNCSSPSRGDRPTASLMPGTRKRALAQSSEDKGLELLETKPPKRSPRLEPGSFLLPPLSLSFLLQGRQLPGNQQDPRAPLVHSHEPLGLAPSLLSLCQHEETVQPRNRFPPAAGLGQTH
uniprot
proteins
function
FUNCTION: Acts as a transcriptional regulator in adaptive response to low oxygen tension. Acts as a regulator of hypoxia-inducible gene expression (PubMed:11734856, PubMed:21546903, PubMed:9840812). Plays a role in the development of the cardiorespiratory system (PubMed:18070924). {ECO:0000269|PubMed:11734856, ECO:0000269|PubMed:18070924, ECO:0000269|PubMed:21546903, ECO:0000269|PubMed:9840812}.; FUNCTION: [Isoform 1]: Acts as a positive regulator of hypoxia-inducible gene expression. Associates to core DNA sequence 5'-TACGTG-3' within the hypoxia response element (HRE) of target gene promoters in a ARNT-dependent manner, and hence also participates in the transcriptional activation of reporter genes driven by HRE (PubMed:9840812). {ECO:0000269|PubMed:9840812}.; FUNCTION: [Isoform 2]: Attenuates the ability of transcription factor HIF1A, EPAS1 and the HIF1A-ARNT complex to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. Functions as an inhibitor of angiogenesis in hypoxic cells of the cornea. May act as a tumor suppressor (PubMed:11734856). May also be involved in apoptosis (PubMed:21546903). {ECO:0000269|PubMed:11734856, ECO:0000269|PubMed:21546903}.; FUNCTION: [Isoform 3]: Attenuates the ability of transcription factor HIF1A, EPAS1 and the HIF1A-ARNT complex to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation (PubMed:18070924). Also plays a role in the development of the lung and heart during embryonic and neonatal stages (PubMed:18070924). {ECO:0000269|PubMed:18070924}.
uniprot
proteins
mass_dalton
73044
uniprot
proteins
post_translational_modification
PTM: In normoxia, hydroxylated on Pro-487 in the oxygen-dependent degradation domain (ODD) by PHD. The hydroxylated proline promotes interaction with VHL, initiating rapid ubiquitination and subsequent proteasomal degradation (By similarity). {ECO:0000250|UniProtKB:Q9Y2N7}.; PTM: Ubiquitinated; ubiquitination occurs in a VHL- and oxygen-dependent pathway and subsequently targeted for proteasomal degradation. {ECO:0000250|UniProtKB:Q9Y2N7}.
uniprot
proteins
pubmed
11734856
uniprot
proteins
pubmed
12119283
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17355974
uniprot
proteins
pubmed
18070924
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21546903
uniprot
proteins
pubmed
24092767
uniprot
proteins
pubmed
9840812
uniprot
proteins
sequence_length
662
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y2N7}. Cytoplasm {ECO:0000250|UniProtKB:Q9Y2N7}. Note=In the nuclei of all periportal and perivenous hepatocytes. In the distal perivenous zone, detected in the cytoplasm of the hepatocytes. Localized in the cytoplasm and nuclei under normoxia, but increased in the nucleus under hypoxic conditions. Colocalized with HIF1A in kidney tumors. {ECO:0000250|UniProtKB:Q9JHS2, ECO:0000250|UniProtKB:Q9Y2N7}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:21546903, ECO:0000269|PubMed:24092767}. Cytoplasm {ECO:0000269|PubMed:21546903, ECO:0000269|PubMed:24092767}. Nucleus speckle {ECO:0000269|PubMed:21546903}. Mitochondrion {ECO:0000269|PubMed:21546903}. Note=Colocalizes with BAD in the cytoplasm (PubMed:21546903). Colocalizes with EPAS1 and HIF1A in the nucleus and speckles (PubMed:21546903). Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner (PubMed:24092767). {ECO:0000269|PubMed:21546903, ECO:0000269|PubMed:24092767}.
uniprot
proteins