H2AZ1
entrez
3015
canonical
uniprot
P0C0S5
canonical
ensembl
ENSG00000164032
resolver
ensp
ENSP00000296417
resolver
enst
ENST00000296417
resolver
genesymbol
H2AZ1
resolver
genesymbol_syn
H2AFZ
resolver
genesymbol_syn
H2AZ
resolver
hgnc
HGNC:4741
resolver
uniprot
B2RD56
resolver
uniprot
P17317
resolver
uniprot
Q6I9U0
resolver
uniprot_entry
H2AZ_HUMAN
resolver
uniprot_sec
B2RD56
resolver
uniprot_sec
P17317
resolver
uniprot_sec
Q6I9U0
resolver
amino_acid_sequence
MAGGKAGKDSGKAKTKAVSRSQRAGLQFPVGRIHRHLKSRTTSHGRVGATAAVYSAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIHKSLIGKKGQQKTV
uniprot
proteins
function
FUNCTION: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division. {ECO:0000269|PubMed:15878876}.
uniprot
proteins
mass_dalton
13553
uniprot
proteins
mutagenesis
MUTAGEN 5..14; /note="KAGKDSGKAK->AAGKDSGAAA: Decreased acetylation by KAT2A."; /evidence="ECO:0000269|PubMed:31527837"; MUTAGEN 5..8; /note="KAGK->AAGA: Decreased acetylation by KAT2A."; /evidence="ECO:0000269|PubMed:31527837"; MUTAGEN 12..14; /note="KAK->AAA: Decreased acetylation by KAT2A."; /evidence="ECO:0000269|PubMed:31527837"; MUTAGEN 83; /note="T->I: Decreases interaction with VPS72. Almost abolishes interaction with VPS72; when associated with N-93. Abolishes interaction with VPS72; when associated with N-93 and IG-101."; /evidence="ECO:0000269|PubMed:26974126"; MUTAGEN 93; /note="G->N: Decreases interaction with VPS72. Almost abolishes interaction with VPS72; when associated with I-83. Abolishes interaction with VPS72; when associated with I-83 and IG-101."; /evidence="ECO:0000269|PubMed:26974126"; MUTAGEN 98; /note="D->N: No effect on interaction with VPS72."; /evidence="ECO:0000269|PubMed:26974126"; MUTAGEN 101; /note="I->IG: Abolishes interaction with VPS72; when associated with I-83 and N-93."; /evidence="ECO:0000269|PubMed:26974126
uniprot
proteins
post_translational_modification
PTM: Monoubiquitination of Lys-122 gives a specific tag for epigenetic transcriptional repression. {ECO:0000269|PubMed:11835281}.; PTM: Acetylated on Lys-5, Lys-8, Lys-12 and Lys-14 by KAT2A; KAT2A is recruited by the XPC complex in absence of DNA damage (PubMed:31527837). Acetylated on Lys-5, Lys-8 and Lys-12 during interphase; acetylation disappears at mitosis (By similarity). Acetylation by the NuA4 histone acetyltransferase complex is required for hematopoietic stem cell maintenance (By similarity). {ECO:0000250|UniProtKB:P0C0S6, ECO:0000269|PubMed:31527837}.; PTM: Monomethylated on Lys-5 and Lys-8 by SETD6. SETD6 predominantly methylates Lys-8, lys-5 being a possible secondary site. {ECO:0000269|PubMed:23324626}.; PTM: Not phosphorylated. {ECO:0000250|UniProtKB:P0C0S4}.; PTM: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. {ECO:0000269|PubMed:31645732}.
uniprot
proteins
protein_family
Histone H2A family
uniprot
proteins
pubmed
11101893
uniprot
proteins
pubmed
11835281
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
15878876
uniprot
proteins
pubmed
16319397
uniprot
proteins
pubmed
16457589
uniprot
proteins
pubmed
16627869
uniprot
proteins
pubmed
1697587
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20473270
uniprot
proteins
pubmed
23324626
uniprot
proteins
pubmed
24463511
uniprot
proteins
pubmed
26237645
uniprot
proteins
pubmed
26974126
uniprot
proteins
pubmed
28645917
uniprot
proteins
pubmed
30327463
uniprot
proteins
pubmed
31527837
uniprot
proteins
pubmed
31645732
uniprot
proteins
pubmed
3344202
uniprot
proteins
pubmed
34961760
uniprot
proteins
sequence_length
128
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Chromosome.
uniprot
proteins