FBXO32
entrez
114907
canonical
uniprot
Q969P5
canonical
ensembl
ENSG00000156804
resolver
ensp
ENSP00000390790
resolver
ensp
ENSP00000428205
resolver
genesymbol
FBXO32
resolver
hgnc
HGNC:16731
resolver
uniprot
A4KYM0
resolver
uniprot
I6L984
resolver
uniprot
Q0VAQ6
resolver
uniprot
Q498Y9
resolver
uniprot_entry
FBX32_HUMAN
resolver
uniprot_entry
I6L984_HUMAN
resolver
uniprot_entry
Q0VAQ6_HUMAN
resolver
uniprot_entry
Q498Y9_HUMAN
resolver
uniprot_sec
A4KYM0
resolver
amino_acid_sequence
MPFLGQDWRSPGQNWVKTADGWKRFLDEKSGSFVSDLSSYCNKEVYNKENLFNSLNYDVAAKKRKKDMLNSKTKTQYFHQEKWIYVHKGSTKERHGYCTLGEAFNRLDFSTAILDSRRFNYVVRLLELIAKSQLTSLSGIAQKNFMNILEKVVLKVLEDQQNIRLIRELLQTLYTSLCTLVQRVGKSVLVGNINMWVYRMETILHWQQQLNNIQITRPAFKGLTFTDLPLCLQLNIMQRLSDGRDLVSLGQAAPDLHVLSEDRLLWKKLCQYHFSERQIRKRLILSDKGQLDWKKMYFKLVRCYPRKEQYGDTLQLCKHCHILSWKGTDHPCTANNPESCSVSLSPQDFINLFKF
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in FBXO32 are associated with susceptibility to dilated cardiomyopathy (DCM). A disorder characterized by ventricular and impaired systolic function, resulting in heart failure and arrhythmia. Patient are at risk of premature death. {ECO:0000269|PubMed:26753747, ECO:0000269|PubMed:26768247}.
uniprot
proteins
function
FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1. Negatively regulates macrophage efferocytosis by promoting the ubiquitination of the transcription factor KLF4, suppressing the receptor tyrosine kinase MERTK transcription (By similarity). Regulates LPS-induced apoptosis and mitochondrial dysfunction through ANXA1 ubiquitination and degradation (By similarity). Mediates cyclin D1 protein stabilization via 'Lys-27'-linked ubiquitination (PubMed:40307251). {ECO:0000250|UniProtKB:Q9CPU7, ECO:0000269|PubMed:15531760, ECO:0000269|PubMed:40307251}.
uniprot
proteins
mass_dalton
41637
uniprot
proteins
mutagenesis
MUTAGEN 169; /note="L->Q: Significantly increases nuclear localization."; /evidence="ECO:0000269|PubMed:22249105
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
11679633
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15531760
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
22249105
uniprot
proteins
pubmed
26753747
uniprot
proteins
pubmed
26768247
uniprot
proteins
pubmed
40307251
uniprot
proteins
sequence_length
355
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22249105, ECO:0000269|PubMed:26768247}. Nucleus {ECO:0000269|PubMed:22249105, ECO:0000269|PubMed:40307251}. Note=Shuttles between cytoplasm and the nucleus.
uniprot
proteins