GDPD5
entrez
81544
canonical
uniprot
Q8WTR4
canonical
ensembl
ENSG00000158555
resolver
ensp
ENSP00000337972
resolver
ensp
ENSP00000434050
resolver
ensp
ENSP00000435196
resolver
ensp
ENSP00000437049
resolver
ensp
ENSP00000557073
resolver
ensp
ENSP00000557077
resolver
ensp
ENSP00000557078
resolver
ensp
ENSP00000596922
resolver
ensp
ENSP00000596924
resolver
ensp
ENSP00000596926
resolver
genesymbol
GDPD5
resolver
genesymbol_syn
GDE2
resolver
hgnc
HGNC:28804
resolver
uniprot
Q49AQ5
resolver
uniprot
Q6UX76
resolver
uniprot
Q7Z4S0
resolver
uniprot
Q8N781
resolver
uniprot
Q8NCB7
resolver
uniprot
Q8TB77
resolver
uniprot_entry
GDE2_HUMAN
resolver
uniprot_sec
Q49AQ5
resolver
uniprot_sec
Q6UX76
resolver
uniprot_sec
Q7Z4S0
resolver
uniprot_sec
Q8N781
resolver
uniprot_sec
Q8NCB7
resolver
uniprot_sec
Q8TB77
resolver
activity_regulation
ACTIVITY REGULATION: Activated by PRDX1 through reduction of an intramolecular disulfide bond. {ECO:0000250|UniProtKB:Q3KTM2}.
uniprot
proteins
amino_acid_sequence
MVRHQPLQYYEPQLCLSCLTGIYGCRWKRYQRSHDDTTPWERLWFLLLTFTFGLTLTWLYFWWEVHNDYDEFNWYLYNRMGYWSDWPVPILVTTAAAFAYIAGLLVLALCHIAVGQQMNLHWLHKIGLVVILASTVVAMSAVAQLWEDEWEVLLISLQGTAPFLHVGAVAAVTMLSWIVAGQFARAERTSSQVTILCTFFTVVFALYLAPLTISSPCIMEKKDLGPKPALIGHRGAPMLAPEHTLMSFRKALEQKLYGLQADITISLDGVPFLMHDTTLRRTTNVEEEFPELARRPASMLNWTTLQRLNAGQWFLKTDPFWTASSLSPSDHREAQNQSICSLAELLELAKGNATLLLNLRDPPREHPYRSSFINVTLEAVLHSGFPQHQVMWLPSRQRPLVRKVAPGFQQTSGSKEAVASLRRGHIQRLNLRYTQVSRQELRDYASWNLSVNLYTVNAPWLFSLLWCAGVPSVTSDNSHALSQVPSPLWIMPPDEYCLMWVTADLVSFTLIVGIFVLQKWRLGGIRSYNPEQIMLSAAVRRTSRDVSIMKEKLIFSEISDGVEVSDVLSVCSDNSYDTYANSTATPVGPRGGGSHTKTLIERSGR
uniprot
proteins
ec_number
3.1.4.-
uniprot
proteins
ec_number
3.1.4.2
uniprot
proteins
function
FUNCTION: Ecto-phospholipase that cleaves the phosphodiester bond in the glycosylphosphatidylinositol (GPI) anchor of various proteins, releasing them from the plasma membrane into the extracellular space (PubMed:27693046, PubMed:31932507, PubMed:33731436). Cleaves the GPI-anchor of glypican-6/GPC6, thereby positively regulating neuron differentiation in a cell-autonomous manner (PubMed:27693046, PubMed:31932507). May also hydrolyze the GPI-anchor of glypican-3/GPC3 (PubMed:27693046). Cleaves the GPI-anchor of the serine protease inhibitor RECK, leading to its inactivation (PubMed:33731436). RECK inactivation inhibits NOTCH signaling in neighboring cells and induces differentiation of spinal motor neurons (By similarity). RECK inactivation can also regulate amyloid-beta precursor protein (APP) processing by ADAM10 (PubMed:33731436). May additionally catalyze the hydrolysis of the phosphodiester bond in sn-glycerol 3-phosphocholine, potentially contributing to osmotic regulation of cellular glycerophosphocholine levels (By similarity). {ECO:0000250|UniProtKB:Q3KTM2, ECO:0000250|UniProtKB:Q640M6, ECO:0000269|PubMed:27693046, ECO:0000269|PubMed:31932507, ECO:0000269|PubMed:33731436}.
uniprot
proteins
mass_dalton
68586
uniprot
proteins
mutagenesis
MUTAGEN 25; /note="C->S: No effect on neuron differentiation."; /evidence="ECO:0000269|PubMed:27693046"; MUTAGEN 233; /note="H->A: Loss of glycerophospholipase activity."; /evidence="ECO:0000269|PubMed:27693046"; MUTAGEN 275; /note="H->A: Decreased glycerophospholipase activity."; /evidence="ECO:0000269|PubMed:27693046"; MUTAGEN 553; /note="L->S: Loss of endosomal recycling."; /evidence="ECO:0000269|PubMed:31932507
uniprot
proteins
post_translational_modification
PTM: The reduction by PRDX1 of an intramolecular disulfide bond between Cys-25 and Cys-571 could activate the phosphodiesterase activity. {ECO:0000250|UniProtKB:Q3KTM2}.
uniprot
proteins
protein_family
Glycerophosphoryl diester phosphodiesterase family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
27693046
uniprot
proteins
pubmed
31932507
uniprot
proteins
pubmed
33731436
uniprot
proteins
sequence_length
605
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27693046, ECO:0000269|PubMed:31932507, ECO:0000269|PubMed:33731436}; Multi-pass membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:27693046}; Multi-pass membrane protein {ECO:0000255}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q640M6}. Note=Colocalizes with recycling endosome as it undergoes constitutive clathrin- and dynamin-mediated internalization and recycling. {ECO:0000269|PubMed:31932507}.
uniprot
proteins
transmembrane_region
TRANSMEM 43..63; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 90..110; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 126..146; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 161..181; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 193..213; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 497..517; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins