Rnf146
entrez
308051
canonical
uniprot
Q5XIK5
canonical
ensembl
ENSRNOG00000011588
resolver
ensembl
ENSRNOG00055003168
resolver
ensembl
ENSRNOG00060023731
resolver
ensembl
ENSRNOG00065019124
resolver
ensp
ENSRNOP00000015421
resolver
ensp
ENSRNOP00000081042
resolver
ensp
ENSRNOP00055003645
resolver
ensp
ENSRNOP00055003652
resolver
ensp
ENSRNOP00055003654
resolver
ensp
ENSRNOP00060033995
resolver
ensp
ENSRNOP00060034014
resolver
ensp
ENSRNOP00065025657
resolver
ensp
ENSRNOP00065025660
resolver
ensp
ENSRNOP00065025675
resolver
enst
ENSRNOT00000015421
resolver
enst
ENSRNOT00000119984
resolver
enst
ENSRNOT00055004921
resolver
enst
ENSRNOT00055004929
resolver
enst
ENSRNOT00055004931
resolver
enst
ENSRNOT00060041066
resolver
enst
ENSRNOT00060041085
resolver
enst
ENSRNOT00065032146
resolver
enst
ENSRNOT00065032149
resolver
enst
ENSRNOT00065032164
resolver
genesymbol
Rnf146
resolver
uniprot
A0A140TAB2
resolver
uniprot_entry
A0A140TAB2_RAT
resolver
uniprot_entry
RN146_RAT
resolver
amino_acid_sequence
MAGCGEIDHSLNMLPTNKKASETCSNTAPSLTVPECAICLQTCVHPVSLPCKHVFCYLCVKGASWLGKRCALCRQEIPEDFLDKPTLLSPEELKAASRGNGEYVWYYEGRNGWWQYDERTSRELEDAFSKGKKNTEMLIAGFLYVADLENMVQYRRNEHGRRRKIKRDIIDIPKKGVAGLRLDCDSNTVNLARESSADGADSGSAHTGASVQLPVPSSTRPLTSVDGQLTSPVTPSPDAGASLEDSFAHLQLSGDSIAERSHRGEGEEDHESPSSGRVPDTSTEETESDASSDIEDAPVVVAQHSLTQQRLLVSSANQTVAERSDRPVAGGGTMSVNVRSRRPDGQCTVTEV
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated (PARsylated) proteins and mediates their ubiquitination and subsequent degradation. May regulate many important biological processes, such as cell survival and DNA damage response. Acts as an activator of the Wnt signaling pathway by mediating the ubiquitination of PARsylated AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex. Acts in cooperation with tankyrase proteins (TNKS and TNKS2), which mediate PARsylation of target proteins AXIN1, AXIN2, BLZF1, CASC3, TNKS and TNKS2. Recognizes and binds tankyrase-dependent PARsylated proteins via its WWE domain and mediates their ubiquitination, leading to their degradation. Different ubiquitin linkage types have been observed: TNKS2 undergoes ubiquitination at 'Lys-48' and 'Lys-63', while AXIN1 is only ubiquitinated at 'Lys-48'. May regulate TNKS and TNKS2 subcellular location, preventing aggregation at a centrosomal location. Neuroprotective protein (By similarity). Protects the brain against N-methyl-D-aspartate (NMDA) receptor-mediated glutamate excitotoxicity and ischemia, by interfering with PAR-induced cell death, called parthanatos (By similarity). Prevents nuclear translocation of AIFM1 in a PAR-binding dependent manner (By similarity). Does not affect PARP1 activation. Protects against cell death induced by DNA damaging agents, such as N-methyl-N-nitro-N-nitrosoguanidine (MNNG) and rescues cells from G1 arrest (By similarity). Promotes cell survival after gamma-irradiation. Facilitates DNA repair (By similarity). {ECO:0000250|UniProtKB:Q9CZW6, ECO:0000250|UniProtKB:Q9NTX7}.
uniprot
proteins
mass_dalton
38224
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; autoubiquitinated. Autoubiquitination is enhanced upon poly(ADP-ribose)-binding (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
352
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocates to the nucleus after DNA damage, such as laser-induced DNA breaks, and concentrates at DNA breaks. This translocation requires PARP1 activation and PAR-binding (By similarity). {ECO:0000250}.
uniprot
proteins