Dennd1b
entrez
329260
canonical
uniprot
Q3U1T9
canonical
ensembl
ENSMUSG00000056268
resolver
ensp
ENSMUSP00000092082
resolver
ensp
ENSMUSP00000127580
resolver
ensp
ENSMUSP00000296262
resolver
ensp
ENSMUSP00000296264
resolver
ensp
ENSMUSP00000296265
resolver
ensp
ENSMUSP00000296272
resolver
genesymbol
Dennd1b
resolver
uniprot
B2RUR7
resolver
uniprot
E9Q246
resolver
uniprot
Q8CG96
resolver
uniprot
Q9D5B9
resolver
uniprot_entry
DEN1B_MOUSE
resolver
uniprot_sec
B2RUR7
resolver
uniprot_sec
E9Q246
resolver
uniprot_sec
Q8CG96
resolver
uniprot_sec
Q9D5B9
resolver
amino_acid_sequence
MDRRTRENPERTFDLVLKVKCHASENEDPEVLWKFPEDFGDQEVLQSVPKFCFPFDVERVSQNQVGQHFTFVLTDMESKQRFGFCRLTSGGRICLCILSYLPWFEVYYKLLNTLADYLAKELEEDLNETLKSLYNHPVPKANTPVNLSVHSCFITPDITGLPTIPESRNLTEYFVAVDVNNMLRLYASMLHERRIIITSSKLSTLTACLHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVVLNVDTNTLESPFNDLSSLPSDVVSALKNKLKKQSTATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEESFVKHRSSVMKQFLETAVNLQLFKQFIDGRLAKLNAGRGFSDIFEEEITSGGFCGGSPRSYQQWVYTVKKGGALFNTAVTKATPAVRTAYKFAKSHARLGLKEVKSRLKHKDNEEEYGTCSGLVQYTPVYTLHNEKGENREKHKLSQTHLKRPHKSLDGTLYDDDDDDDDIERASKISSEDGEETRAYFYESDDSVEAQVKAPYSGEMDLLGEILDTLSTHSSDQGKLAPAKSLDFFRSMDDIDYKPTNKSNAPSENNLALLCASGDQGEWNLGQDDSALHGRQLPPSPRKRVSSGGLTESLFILKEESREKPLCADSVSGPTVVGKPAPTSGLRSQPAAPEASQTERGRAEVKQTPGQAPLQSEDLSVPGPGSRQSTFVPWEKAGKEDTKPSKDVGLLQEVVSLCHMSCDFQQDLNISEESRSGNQT
uniprot
proteins
function
FUNCTION: Guanine nucleotide exchange factor (GEF) for RAB35 that acts as a regulator of T-cell receptor (TCR) internalization in TH2 cells. Acts by promoting the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Plays a role in clathrin-mediated endocytosis. Controls cytokine production in TH2 lymphocytes by controlling the rate of TCR internalization and routing to endosomes: acts by mediating clathrin-mediated endocytosis of TCR via its interaction with the adapter protein complex 2 (AP-2) and GEF activity. Dysregulation leads to impaired TCR down-modulation and recycling, affecting cytokine production in TH2 cells. {ECO:0000269|PubMed:26774822}.
uniprot
proteins
mass_dalton
85526
uniprot
proteins
mutagenesis
MUTAGEN 246; /note="G->D: Abolishes guanine nucleotide exchange factor (GEF) activity and impaired TCR down-modulation and recycling in TH2 cells."; /evidence="ECO:0000269|PubMed:26774822"; MUTAGEN 482; /note="K->A: Impaired interaction with the AP-2 complex and impaired TCR down-modulation and recycling in TH2 cells; when associated with 547-A--A-549."; /evidence="ECO:0000269|PubMed:26774822"; MUTAGEN 547..549; /note="DLL->AAA: Impaired interaction with the AP-2 complex and impaired TCR down-modulation and recycling in TH2 cells; when associated with A-482."; /evidence="ECO:0000269|PubMed:26774822
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine and/or threonine, possibly regulating the guanine nucleotide exchange factor (GEF) activity. {ECO:0000250|UniProtKB:Q6P3S1}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26774822
uniprot
proteins
sequence_length
766
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q6P3S1}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q6P3S1}.
uniprot
proteins