Fn3k
entrez
63828
canonical
uniprot
Q9ER35
canonical
ensembl
ENSMUSG00000025175
resolver
ensp
ENSMUSP00000026175
resolver
ensp
ENSMUSP00000099303
resolver
enst
ENSMUST00000026175
resolver
enst
ENSMUST00000103014
resolver
genesymbol
Fn3k
resolver
uniprot
F6UCJ6
resolver
uniprot
Q7TQJ3
resolver
uniprot
Q9D6N6
resolver
uniprot_entry
F6UCJ6_MOUSE
resolver
uniprot_entry
FN3K_MOUSE
resolver
uniprot_entry
Q7TQJ3_MOUSE
resolver
uniprot_sec
Q9D6N6
resolver
amino_acid_sequence
MEQLLRAQLHTTTLRAFGSSGGGCISEGYAYYTDSGPVFVKVNRRTQARQMFEGEMASLEALRNTGLVRVPKPMKVIDLPGGGAVFVMEHLKMKSLSSQASKLGEQMADLHLYNQKLREKSKTRQNTVGCGAEGAEPQGVTKFGFHTVTCCGFIPQVNEWQEDWPTFFTRHRLQAQLDLIEKDYADRETQELWSRLQVKIPDLFAGIEIVPALLHGDLWSGNVAEDDQGPVIYDPASFYGHSEFELAIASMFGGFPRSFFTAYHRKIPKAPGFDKRLLLYQLFNYLNHWNHFGREYRSPSLGVMRKLLR
uniprot
proteins
ec_number
2.7.1.171
uniprot
proteins
ec_number
2.7.1.172
uniprot
proteins
function
FUNCTION: Fructosamine-3-kinase involved in protein deglycation by mediating phosphorylation of fructoselysine residues on glycated proteins, to generate fructoselysine-3 phosphate (PubMed:11016445, PubMed:16819943). Fructoselysine-3 phosphate adducts are unstable and decompose under physiological conditions (By similarity). Involved in intracellular deglycation in erythrocytes and pancreatic islets (PubMed:16819943, PubMed:20009024). Involved in the response to oxidative stress by mediating deglycation of NFE2L2/NRF2, glycation impairing NFE2L2/NRF2 function (PubMed:31398338). Also able to phosphorylate psicosamines and ribulosamines (By similarity). {ECO:0000250|UniProtKB:Q9H479, ECO:0000269|PubMed:11016445, ECO:0000269|PubMed:16819943, ECO:0000269|PubMed:20009024, ECO:0000269|PubMed:31398338}.
uniprot
proteins
mass_dalton
35032
uniprot
proteins
protein_family
Fructosamine kinase family
uniprot
proteins
pubmed
11016445
uniprot
proteins
pubmed
15331600
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16819943
uniprot
proteins
pubmed
20009024
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31398338
uniprot
proteins
sequence_length
309
uniprot
proteins