DDX39A
entrez
10212
canonical
uniprot
O00148
canonical
ensembl
ENSG00000123136
resolver
ensp
ENSP00000242776
resolver
ensp
ENSP00000596098
resolver
genesymbol
DDX39A
resolver
genesymbol_syn
DDX39
resolver
hgnc
HGNC:17821
resolver
uniprot
B1Q2N1
resolver
uniprot
Q8N5M0
resolver
uniprot
Q9BVP6
resolver
uniprot
Q9H5W0
resolver
uniprot_entry
DX39A_HUMAN
resolver
uniprot_sec
B1Q2N1
resolver
uniprot_sec
Q8N5M0
resolver
uniprot_sec
Q9BVP6
resolver
uniprot_sec
Q9H5W0
resolver
amino_acid_sequence
MAEQDVENDLLDYDEEEEPQAPQESTPAPPKKDIKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQIEPVNGQVTVLVMCHTRELAFQISKEYERFSKYMPSVKVSVFFGGLSIKKDEEVLKKNCPHVVVGTPGRILALVRNRSFSLKNVKHFVLDECDKMLEQLDMRRDVQEIFRLTPHEKQCMMFSATLSKDIRPVCRKFMQDPMEVFVDDETKLTLHGLQQYYVKLKDSEKNRKLFDLLDVLEFNQVIIFVKSVQRCMALAQLLVEQNFPAIAIHRGMAQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIVFNYDMPEDSDTYLHRVARAGRFGTKGLAITFVSDENDAKILNDVQDRFEVNVAELPEEIDISTYIEQSR
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: Helicase that plays an essential role in mRNA export and is involved in multiple steps in RNA metabolism including alternative splicing (PubMed:33941617, PubMed:38801080). Regulates nuclear mRNA export to the cytoplasm through association with ECD (PubMed:33941617). Also involved in spliceosomal uridine-rich small nuclear RNA (U snRNA) export by stimulating the RNA binding of adapter PHAX (PubMed:39011894). Plays a role in the negative regulation of type I IFN production by increasing the nuclear retention of antiviral transcripts and thus reducing their protein expression (PubMed:32393512). Independently of the interferon pathway, plays an antiviral role against alphaviruses by binding to a 5' conserved sequence element in the viral genomic RNA (PubMed:37949067). {ECO:0000269|PubMed:15047853, ECO:0000269|PubMed:17548965, ECO:0000269|PubMed:32393512, ECO:0000269|PubMed:33941617, ECO:0000269|PubMed:37949067, ECO:0000269|PubMed:38801080}.
uniprot
proteins
mass_dalton
49130
uniprot
proteins
mutagenesis
MUTAGEN 223; /note="C->S: Exhibits a switch in complex formation from the apo-AREX complex to the apo-TREX complex."; /evidence="ECO:0000269|PubMed:38225262
uniprot
proteins
post_translational_modification
PTM: SUMOylated by RANBP2; SUMOylation modification affects its ability to bind RNA. {ECO:0000269|PubMed:32393512}.
uniprot
proteins
protein_family
DEAD box helicase family
uniprot
proteins
protein_family
DECD subfamily
uniprot
proteins
pubmed
14667819
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15047853
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16478985
uniprot
proteins
pubmed
17196963
uniprot
proteins
pubmed
17548965
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21859714
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23652018
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
32393512
uniprot
proteins
pubmed
33941617
uniprot
proteins
pubmed
37949067
uniprot
proteins
pubmed
38225262
uniprot
proteins
pubmed
38801080
uniprot
proteins
pubmed
39011894
uniprot
proteins
sequence_length
427
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21859714, ECO:0000269|PubMed:32393512, ECO:0000269|PubMed:33941617, ECO:0000269|PubMed:38225262}. Cytoplasm {ECO:0000269|PubMed:21859714, ECO:0000269|PubMed:37949067}. Note=Can translocate to the cytoplasm in the presence of MX1 (PubMed:21859714). Accumulates in the cytoplasm upon infection with chikungunya virus (PubMed:37949067). {ECO:0000269|PubMed:21859714, ECO:0000269|PubMed:37949067}.
uniprot
proteins