E2f6
entrez
50496
canonical
uniprot
O54917
canonical
ensembl
ENSMUSG00000057469
resolver
ensp
ENSMUSP00000020908
resolver
enst
ENSMUST00000020908
resolver
genesymbol
E2f6
resolver
uniprot
Q8K456
resolver
uniprot
Q8VHT4
resolver
uniprot_entry
E2F6_MOUSE
resolver
uniprot_entry
Q8VHT4_MOUSE
resolver
uniprot_sec
Q8K456
resolver
amino_acid_sequence
MSQQRTARRQPSLLVDPAQETVRRRCRDPINVENLLPSKIRINLEENVQYVSMRKALKVKRPRFDVSLVYLTRKFMDLVRSAPGGILDLNKVATKLGVRKRRVYDITNVLDGIELVEKKSKNHIRWIGSDLNNFGAAPQQKKLQAELSDLSAMEDALDELIKDCAQQLLELTDDKENERLAYVTYQDIHGIQAFHEQIVIAVKAPEETRLDVPAPREDSITVHIRSTKGPIDVYLCEVEQNHSNGKTNDGIGASPSKSSHPQCPEKEDEPPQ
uniprot
proteins
function
FUNCTION: Inhibitor of E2F-dependent transcription (PubMed:9403682). Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' (PubMed:18667754, PubMed:9403682). Has a preference for the 5'-TTTCCCGC-3' E2F recognition site (PubMed:9403682). E2F6 lacks the transcriptional activation and pocket protein binding domains (PubMed:9403682). Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression (By similarity). Represses expression of some meiosis-specific genes, including SLC25A31/ANT4 (PubMed:18667754). May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase (By similarity). {ECO:0000250|UniProtKB:O75461, ECO:0000269|PubMed:18667754, ECO:0000269|PubMed:9403682}.
uniprot
proteins
mass_dalton
30852
uniprot
proteins
protein_family
E2F/DP family
uniprot
proteins
pubmed
18667754
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
9403682
uniprot
proteins
sequence_length
272
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O75461}.
uniprot
proteins