Homer3
entrez
26558
canonical
uniprot
Q99JP6
canonical
ensembl
ENSMUSG00000003573
resolver
ensp
ENSMUSP00000105751
resolver
ensp
ENSMUSP00000117033
resolver
ensp
ENSMUSP00000258089
resolver
ensp
ENSMUSP00000258090
resolver
ensp
ENSMUSP00000258096
resolver
ensp
ENSMUSP00000258097
resolver
genesymbol
Homer3
resolver
uniprot
D3Z6N9
resolver
uniprot
Q9Z215
resolver
uniprot_entry
HOME3_MOUSE
resolver
uniprot_sec
D3Z6N9
resolver
uniprot_sec
Q9Z215
resolver
amino_acid_sequence
MSTAREQPIFSTRAHVFQIDPTTKRNWIPAGKHALTVSYFYDATRNVYRIISIGGAKAIINSTVTPNMTFTKTSQKFGQWADSRANTVYGLGFASEQQLTQFAEKFQEVKEAARLAREKSQDGGEFTSTGLALASHQVPPSPLVSTNGPGEEKLFRSQSADTPGPTERERLKKMLSEGSVGEVQWEAEFFALQDSNQRLAGALREANAAATQWRQQLEVQRAEAELLRQRVAELEAQVAVEPVRAGEKEATSQSVEQLEARVQTKDQTLKNQSTGTREAPDTAEREETQQQVQDLETRNAELEQQLRSMECNLEEARAERERARAEVGRAAQLLDVRLFELSELREGLARLAEAAP
uniprot
proteins
function
FUNCTION: Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (By similarity). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901). {ECO:0000250|UniProtKB:Q9NSC5, ECO:0000269|PubMed:18218901}.
uniprot
proteins
mass_dalton
39694
uniprot
proteins
protein_family
Homer family
uniprot
proteins
pubmed
11418862
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
18218901
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9808458
uniprot
proteins
pubmed
9808459
uniprot
proteins
sequence_length
356
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Postsynaptic density {ECO:0000250}. Synapse {ECO:0000250}. Note=Postsynaptic density of neuronal cells. {ECO:0000250}.
uniprot
proteins