Clasp2
entrez
76499
canonical
uniprot
Q8BRT1
canonical
ensembl
ENSMUSG00000033392
resolver
ensp
ENSMUSP00000107469
resolver
ensp
ENSMUSP00000128460
resolver
ensp
ENSMUSP00000130201
resolver
ensp
ENSMUSP00000149670
resolver
ensp
ENSMUSP00000150741
resolver
enst
ENSMUST00000111838
resolver
enst
ENSMUST00000166734
resolver
enst
ENSMUST00000214522
resolver
enst
ENSMUST00000216817
resolver
genesymbol
Clasp2
resolver
genesymbol_syn
Kiaa0627
resolver
uniprot
A0A1L1SRX3
resolver
uniprot
A0A1L1SUE6
resolver
uniprot
A2RRR3
resolver
uniprot
B9EJA4
resolver
uniprot
E9Q8N5
resolver
uniprot
F6Q6T0
resolver
uniprot
Q08EB5
resolver
uniprot
Q08EB6
resolver
uniprot
Q3UF57
resolver
uniprot
Q8BSE7
resolver
uniprot
Q8CHE3
resolver
uniprot
Q99JI3
resolver
uniprot
Q9DB80
resolver
uniprot_entry
A0A1L1SRX3_MOUSE
resolver
uniprot_entry
A0A1L1SUE6_MOUSE
resolver
uniprot_entry
A2RRR3_MOUSE
resolver
uniprot_entry
B9EJA4_MOUSE
resolver
uniprot_entry
CLAP2_MOUSE
resolver
uniprot_entry
E9Q8N5_MOUSE
resolver
uniprot_entry
F6Q6T0_MOUSE
resolver
uniprot_entry
Q08EB5_MOUSE
resolver
uniprot_entry
Q08EB6_MOUSE
resolver
uniprot_entry
Q3UF57_MOUSE
resolver
uniprot_entry
Q8BSE7_MOUSE
resolver
uniprot_sec
Q8CHE3
resolver
uniprot_sec
Q99JI3
resolver
uniprot_sec
Q9DB80
resolver
amino_acid_sequence
MRRLICKRICDYKSFDDEESVDGNRPSSAASAFKVPAPKTPGNPVSSARKPGSAGGPKVGGPSKEGGAGAVDEDDFIKAFTDVPSVQIYSSRELEETLNKIREILSDDKHDWDQRANALKKIRSLLVAGAAQYDCFFQHLRLLDGALKLSAKDLRSQVVREACITVAHLSTVLGNKFDHGAEAIVPTLFNLVPNSAKVMATSGCAAIRFIIRHTHVPRLIPLITSNCTSKSVPVRRRSFEFLDLLLQEWQTHSLERHAAVLVETIKKGIHDADAEARVEARKTYMGLRNHFPGEAETLYNSLEPSYQKSLQTYLKSSGSVASLPQSDRSSSSSQESLNRPFSSKWSTANPSTVAGRVSVGGSKANPLPGSLQRSRSDIDVNAAAGAKAHHAAGQAVRSGRLGAGALNPGSYASLEDTSDKMDGTASDDGRVRAKLSTPLVAVGNAKTDSRGRSRTKMVSQSQPGSRSGSPGRVLTTTALSTVSSGAQRVLVNSASAQKRSKIPRSQGCSREASPSRLSVARSSRIPRPSVSQGCSREASRESSRDTSPVRSFQPLGPGYGISQSSRLSSSVSAMRVLNTGSDVEEAVADALLLGDIRTKKKPARRRYESYGMHSDDDANSDASSACSERSYSSRNGSIPTYMRQTEDVAEVLNRCASSNWSERKEGLLGLQNLLKNQRTLSRIELKRLCEIFTRMFADPHGKVFSMFLETLVDFIQVHKDDLQDWLFVLLTQLLKKMGADLLGSVQAKVQKALDITRESFPNDLQFNILMRFTVDQTQTPSLKVKVAILKYIETLAKQMDPRDFTNSSETRLAVSRVITWTTEPKSSDVRKAAQSVLISLFELNTPEFTMLLGALPKTFQDGATKLLHNHLRNTGNGTQSSMGSPLTRPTPRSPANWSSPLTSPTNTSQNTLSPSAFDYDTENMNSEDIYSSLRGVTEAIQNFSFRSQEDMSEPVRRDPKKEDGDTICSGPGMSDPRAGGDAADGSQPALDNKASLLHSMPLHSSPRSRDYNPYNYSDSISPFNKSALKEAMFDDDADQFPDDLSLDHSDLVAELLKELSNHNERIEERKIALYELMKLTQEESFSVWDEHFKTILLLLLETLGDKEPTIRALALKVLKEILRHQPARFKNYAELTVMKTLEAHKDPHKEVVRSAEEAASVLATSISPEQCIKVLCPIIQTADYPINLAAIKMQTKVIERVSKETLNMLLPEIMPGLIQGYDNSESSVRKACVFCLVAVHAVIGDELKPHLSQLTGSKMKLLNLYIKRAQTGSAGADPTADVSGQS
uniprot
proteins
function
FUNCTION: Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. {ECO:0000250|UniProtKB:O75122, ECO:0000269|PubMed:16914514}.
uniprot
proteins
mass_dalton
140739
uniprot
proteins
mutagenesis
MUTAGEN 6; /note="C->S: Impairs Golgi localization; when associated with S-10."; /evidence="ECO:0000269|PubMed:11290329"; MUTAGEN 10; /note="C->S: Impairs Golgi localization; when associated with S-6."; /evidence="ECO:0000269|PubMed:11290329
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by GSK3B. Phosphorylation by GSK3B may negatively regulate binding to microtubule lattices in lamella. Isoform 2 is phosphorylated on Ser-241.
uniprot
proteins
protein_family
CLASP family
uniprot
proteins
pubmed
11290329
uniprot
proteins
pubmed
12465718
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16123238
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16914514
uniprot
proteins
pubmed
18854161
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26003921
uniprot
proteins
pubmed
28550165
uniprot
proteins
sequence_length
1286
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11290329, ECO:0000269|PubMed:28550165}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Golgi apparatus {ECO:0000269|PubMed:11290329}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:O75122}. Cell membrane {ECO:0000250|UniProtKB:O75122}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:O75122}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:O75122}. Note=Localizes to microtubule plus ends (PubMed:11290329). Localizes to centrosomes, kinetochores and the mitotic spindle from prometaphase. Subsequently localizes to the spindle midzone from anaphase and to the midbody from telophase. In migrating cells localizes to the plus ends of microtubules within the cell body and to the entire microtubule lattice within the lamella. Localizes to the cell cortex and this requires ERC1 and PHLDB2 (By similarity). Colocalizes with KANK1 at the cell cortex, likely recruited in cortical microtubule stabilization complexes (CMSC) at focal adhesions rims (By similarity). Also localizes to meiotic spindle poles. The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (By similarity). {ECO:0000250|UniProtKB:O75122, ECO:0000269|PubMed:11290329}.
uniprot
proteins