Fcrl5
entrez
329693
canonical
uniprot
Q68SN8
canonical
ensembl
ENSMUSG00000048031
resolver
ensp
ENSMUSP00000141311
resolver
ensp
ENSMUSP00000142210
resolver
genesymbol
Fcrl5
resolver
genesymbol_syn
Fcrh3
resolver
uniprot
E9QLI5
resolver
uniprot
Q80WN2
resolver
uniprot
Q8BJA5
resolver
uniprot_entry
FCRL5_MOUSE
resolver
uniprot_sec
E9QLI5
resolver
uniprot_sec
Q80WN2
resolver
uniprot_sec
Q8BJA5
resolver
amino_acid_sequence
MSGSFSPCVVFTQMWLTLLVVTPVNGQHEAAQQSVVSLQPPWTTFFRGEVVTLTCYRFGFSVPQKTKWYQKRKTVKQTPGALVIKAHTLKVHESGEYWCQADSLLPSMHVNVEFSEDFLVLQAPPAVFEGDSVVLRCYAKKGIEAETLTFYKDGKALTLHPQSSEFYIHRANLKDNGQYKCTSKKKWSFGSLYTSNTVVVQVQELFPRPVLRARPSHPIDGSPVTLTCQTQLSAQKSDARLQFCFFRNLQLLGSGCSRSSEFHIPAIWTEESKRYQCKAETVNSQVSKQSTAFIIPVQRASARFQTHIIPASKLVFEGQLLLLNCSVKGVPGPLKFSWYKKDMLNKETKILKSSNAEFKISQVNISDAGEYYCEANNSRRSFVSRAFPITIKVPVSQPVLTLSTGKTQALEGDLMTLHCQSQRGSPCILYEFFYENVSLGNSSILSGGGAYFNFSMSTERSGNYYCTADNGLGAQCSEAIRISIFDMTKNRSVPMAAGITVGLLIMAVGVFLFYCWFSRKAGGKPTSDDSRNPSDSEPQEPTYYNVPACIELQPVYSNEPEENVIYTEVRRTQPRQKHADQESESPRSRCQMAEKK
uniprot
proteins
function
FUNCTION: Plays an important role in B-cell response to antigen that acts both as a negative or positive coreceptor. Inhibits B-cell receptor (BCR) signaling in the absence of CR2 stimulation but engagement with CR2 and the BCR lead to a superior calcium response compared to CR2 and BCR costimulation (By similarity). May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells. May play a role in fertilization (PubMed:36070373). {ECO:0000250|UniProtKB:Q96RD9, ECO:0000269|PubMed:36070373}.
uniprot
proteins
mass_dalton
66779
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on cytoplasmic tyrosines; required for interaction with protein tyrosine phosphatases and protein tyrosine kinases. {ECO:0000250}.
uniprot
proteins
pubmed
15302849
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
36070373
uniprot
proteins
sequence_length
596
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 497..517; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins