CLCA1
entrez
1179
canonical
uniprot
A8K7I4
canonical
ensembl
ENSG00000016490
resolver
ensp
ENSP00000234701
resolver
ensp
ENSP00000378200
resolver
enst
ENST00000234701
resolver
enst
ENST00000394711
resolver
genesymbol
CLCA1
resolver
genesymbol_syn
CACC1
resolver
hgnc
HGNC:2015
resolver
uniprot
B2RAV5
resolver
uniprot
O95151
resolver
uniprot
Q5TDF4
resolver
uniprot
Q9UNF6
resolver
uniprot
Q9UPC6
resolver
uniprot_entry
CLCA1_HUMAN
resolver
uniprot_sec
B2RAV5
resolver
uniprot_sec
O95151
resolver
uniprot_sec
Q5TDF4
resolver
uniprot_sec
Q9UNF6
resolver
uniprot_sec
Q9UPC6
resolver
amino_acid_sequence
MGPFKSSVFILILHLLEGALSNSLIQLNNNGYEGIVVAIDPNVPEDETLIQQIKDMVTQASLYLLEATGKRFYFKNVAILIPETWKTKADYVRPKLETYKNADVLVAESTPPGNDEPYTEQMGNCGEKGERIHLTPDFIAGKKLAEYGPQGRAFVHEWAHLRWGVFDEYNNDEKFYLSNGRIQAVRCSAGITGTNVVKKCQGGSCYTKRCTFNKVTGLYEKGCEFVLQSRQTEKASIMFAQHVDSIVEFCTEQNHNKEAPNKQNQKCNLRSTWEVIRDSEDFKKTTPMTTQPPNPTFSLLQIGQRIVCLVLDKSGSMATGNRLNRLNQAGQLFLLQTVELGSWVGMVTFDSAAHVQNELIQINSGSDRDTLAKRLPAAASGGTSICSGLRSAFTVIRKKYPTDGSEIVLLTDGEDNTISGCFNEVKQSGAIIHTVALGPSAAQELEELSKMTGGLQTYASDQVQNNGLIDAFGALSSGNGAVSQRSIQLESKGLTLQNSQWMNGTVIVDSTVGKDTLFLITWTMQPPQILLWDPSGQKQGGFVVDKNTKMAYLQIPGIAKVGTWKYSLQASSQTLTLTVTSRASNATLPPITVTSKTNKDTSKFPSPLVVYANIRQGASPILRASVTALIESVNGKTVTLELLDNGAGADATKDDGVYSRYFTTYDTNGRYSVKVRALGGVNAARRRVIPQQSGALYIPGWIENDEIQWNPPRPEINKDDVQHKQVCFSRTSSGGSFVASDVPNAPIPDLFPPGQITDLKAEIHGGSLINLTWTAPGDDYDHGTAHKYIIRISTSILDLRDKFNESLQVNTTALIPKEANSEEVFLFKPENITFENGTDLFIAIQAVDKVDLKSEISNIARVSLFIPPQTPPETPSPDETSAPCPNIHINSTIPGIHILKIMWKWIGELQLSIA
uniprot
proteins
ec_number
3.4.-.-
uniprot
proteins
function
FUNCTION: May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. {ECO:0000269|PubMed:11445004, ECO:0000269|PubMed:11842292, ECO:0000269|PubMed:11956057, ECO:0000269|PubMed:23112050, ECO:0000269|PubMed:9828122}.
uniprot
proteins
mass_dalton
100226
uniprot
proteins
mutagenesis
MUTAGEN 150; /note="Q->A: Reduces proteolytic cleavage."; /evidence="ECO:0000269|PubMed:23112050"; MUTAGEN 156; /note="H->A: Abolishes proteolytic cleavage."; /evidence="ECO:0000269|PubMed:23112050"; MUTAGEN 157; /note="E->Q: Abolishes proteolytic cleavage."; /evidence="ECO:0000269|PubMed:23112050"; MUTAGEN 160; /note="H->A: Abolishes proteolytic cleavage."; /evidence="ECO:0000269|PubMed:23112050"; MUTAGEN 167; /note="D->A: Abolishes proteolytic cleavage."; /evidence="ECO:0000269|PubMed:23112050"; MUTAGEN 168; /note="E->A: Abolishes proteolytic cleavage."; /evidence="ECO:0000269|PubMed:23112050
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:9828122}.; PTM: The 125-kDa product is autoproteolytically processed by the metalloprotease domain and yields to two cell-surface-associated subunits, a 90-kDa protein and a group of 37- to 41-kDa proteins. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity. {ECO:0000269|PubMed:23112050, ECO:0000269|PubMed:9828122}.
uniprot
proteins
protein_family
CLCR family
uniprot
proteins
pubmed
10437792
uniprot
proteins
pubmed
11445004
uniprot
proteins
pubmed
11842292
uniprot
proteins
pubmed
11956057
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15696080
uniprot
proteins
pubmed
15919655
uniprot
proteins
pubmed
16012037
uniprot
proteins
pubmed
16151054
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17622767
uniprot
proteins
pubmed
23112050
uniprot
proteins
pubmed
9828122
uniprot
proteins
sequence_length
914
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000269|PubMed:15919655}. Cell membrane {ECO:0000269|PubMed:15919655}; Peripheral membrane protein {ECO:0000269|PubMed:15919655}; Extracellular side {ECO:0000269|PubMed:15919655}. Note=Protein that remains attached to the plasma membrane appeared to be predominantly localized to microvilli.
uniprot
proteins