Dad1
entrez
13135
canonical
uniprot
P61804
canonical
ensembl
ENSMUSG00000022174
resolver
ensp
ENSMUSP00000022781
resolver
ensp
ENSMUSP00000122366
resolver
enst
ENSMUST00000022781
resolver
enst
ENSMUST00000128231
resolver
genesymbol
Dad1
resolver
uniprot
O08552
resolver
uniprot
O70364
resolver
uniprot
P46966
resolver
uniprot
P46968
resolver
uniprot
Q3V3W6
resolver
uniprot
Q96GB7
resolver
uniprot_entry
DAD1_MOUSE
resolver
uniprot_sec
O08552
resolver
uniprot_sec
O70364
resolver
uniprot_sec
P46966
resolver
uniprot_sec
P46968
resolver
uniprot_sec
Q3V3W6
resolver
uniprot_sec
Q96GB7
resolver
amino_acid_sequence
MSASVVSVISRFLEEYLSSTPQRLKLLDAYLLYILLTGALQFGYCLLVGTFPFNSFLSGFISCVGSFILAVCLRIQINPQNKADFQGISPERAFADFLFASTILHLVVMNFVG
uniprot
proteins
function
FUNCTION: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (By similarity). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. {ECO:0000250|UniProtKB:E2R4X3, ECO:0000250|UniProtKB:P61803}.
uniprot
proteins
mass_dalton
12497
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:P61803}.
uniprot
proteins
protein_family
DAD/OST2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7737422
uniprot
proteins
pubmed
9121464
uniprot
proteins
sequence_length
113
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 31..51; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 53..73; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 93..113; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins