Hcn3
entrez
114245
canonical
uniprot
Q9JKA8
canonical
ensembl
ENSRNOG00000020444
resolver
ensembl
ENSRNOG00055025522
resolver
ensembl
ENSRNOG00060032702
resolver
ensembl
ENSRNOG00065024981
resolver
ensp
ENSRNOP00000027785
resolver
ensp
ENSRNOP00055036026
resolver
ensp
ENSRNOP00060046869
resolver
ensp
ENSRNOP00065035111
resolver
enst
ENSRNOT00055044044
resolver
enst
ENSRNOT00060056704
resolver
enst
ENSRNOT00065042906
resolver
genesymbol
Hcn3
resolver
uniprot_entry
HCN3_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by Cs(1+) and ivabradine. Unlike HCN2 and HCN4, HCN3 is insensitive to cyclic nucleotides, such as cAMP or cGMP. This lack of sensitivity of HCN3, despite harboring a functional cyclic nucleotide-binding domain (CNBD), may be explained by its shorter C-terminal sequence, which may alter the normal autoinhibition of the channel. Phosphatidylinositol-4,5-bisphosphate (PIP(2)) shifts HCN3 activation to more depolarized potentials and accelerated activation kinetics. {ECO:0000250|UniProtKB:O88705}.
uniprot
proteins
amino_acid_sequence
MEEEARPAVGDGEAATPARETPPAAPAQARAASGGVPESAPEPKRRQLGTLLQPTVNKFSLRVFGSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENSPPWIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYMHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPSDCWVSMNRMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLRRIGKKNSILQRKRSEPSPGSSSGGVMEQHLVQHDRDMARGIRGLAPGTGARLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSARRSAGSPASPLVPVRAGPLLARGPWASTSRLPAPPARTLHASLSRTGRSQVSLLGPPPGGGGRRLGPRGRPLSASQPSLPQRATGDGSPRRKGSGSERLPPSGLLAKPPGTVQPSRSSVPEPVTPRGPQISANM
uniprot
proteins
function
FUNCTION: Hyperpolarization-activated ion channel that are permeable to sodium and potassium ions, with an about 3:1 preference for potassium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). In particular, plays a pivotal role in maintaining excitability and promoting rhythmic burst firing within hypothalamic nuclei. Exerts a significant influence on the configuration of the cardiac action potential waveform. Does not appear to play a prominent role in the processing of acute, neuropathic, or inflammatory pain. {ECO:0000250|UniProtKB:O88705}.
uniprot
proteins
mass_dalton
86809
uniprot
proteins
protein_family
Potassium channel HCN family
uniprot
proteins
pubmed
11000485
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
780
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O88705}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 97..117; /note="Helical; Name=Segment S1"; /evidence="ECO:0000250|UniProtKB:O60741"; TRANSMEM 124..144; /note="Helical; Name=Segment S2"; /evidence="ECO:0000250|UniProtKB:O60741"; TRANSMEM 171..191; /note="Helical; Name=Segment S3"; /evidence="ECO:0000250|UniProtKB:O60741"; TRANSMEM 201..221; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000250|UniProtKB:O60741"; TRANSMEM 253..273; /note="Helical; Name=Segment S5"; /evidence="ECO:0000250|UniProtKB:O60741"; TRANSMEM 329..349; /note="Helical; Name=Segment S6"; /evidence="ECO:0000250|UniProtKB:O60741
uniprot
proteins