P4HA2
entrez
8974
canonical
uniprot
O15460
canonical
ensembl
ENSG00000072682
resolver
ensp
ENSP00000166534
resolver
ensp
ENSP00000353772
resolver
ensp
ENSP00000368379
resolver
ensp
ENSP00000368394
resolver
ensp
ENSP00000368398
resolver
ensp
ENSP00000559383
resolver
ensp
ENSP00000559414
resolver
ensp
ENSP00000614851
resolver
ensp
ENSP00000668233
resolver
genesymbol
P4HA2
resolver
hgnc
HGNC:8547
resolver
uniprot
D3DQ85
resolver
uniprot
D3DQ86
resolver
uniprot
Q05DA4
resolver
uniprot
Q8WWN0
resolver
uniprot_entry
P4HA2_HUMAN
resolver
uniprot_entry
Q05DA4_HUMAN
resolver
uniprot_sec
D3DQ85
resolver
uniprot_sec
D3DQ86
resolver
uniprot_sec
Q8WWN0
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by poly(L-proline) only at very high concentrations. {ECO:0000269|PubMed:9211872}.
uniprot
proteins
amino_acid_sequence
MKLWVSALLMAWFGVLSCVQAEFFTSIGHMTDLIYAEKELVQSLKEYILVEEAKLSKIKSWANKMEALTSKSAADAEGYLAHPVNAYKLVKRLNTDWPALEDLVLQDSAAGFIANLSVQRQFFPTDEDEIGAAKALMRLQDTYRLDPGTISRGELPGTKYQAMLSVDDCFGMGRSAYNEGDYYHTVLWMEQVLKQLDAGEEATTTKSQVLDYLSYAVFQLGDLHRALELTRRLLSLDPSHERAGGNLRYFEQLLEEEREKTLTNQTEAELATPEGIYERPVDYLPERDVYESLCRGEGVKLTPRRQKRLFCRYHHGNRAPQLLIAPFKEEDEWDSPHIVRYYDVMSDEEIERIKEIAKPKLARATVRDPKTGVLTVASYRVSKSSWLEEDDDPVVARVNRRMQHITGLTVKTAELLQVANYGVGGQYEPHFDFSRNDERDTFKHLGTGNRVATFLNYMSDVEAGGATVFPDLGAAIWPKKGTAVFWYNLLRSGEGDYRTRHAACPVLVGCKWVSNKWFHERGQEFLRPCGSTEVD
uniprot
proteins
disease_involvement
DISEASE: Myopia 25, autosomal dominant (MYP25) [MIM:617238]: A refractive error of the eye, in which parallel rays from a distant object come to focus in front of the retina, vision being better for near objects than for far. {ECO:0000269|PubMed:25741866}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
1.14.11.2
uniprot
proteins
function
FUNCTION: Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. {ECO:0000269|PubMed:9211872}.
uniprot
proteins
mass_dalton
60902
uniprot
proteins
protein_family
P4HA family
uniprot
proteins
pubmed
11606192
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25741866
uniprot
proteins
pubmed
7753822
uniprot
proteins
pubmed
9211872
uniprot
proteins
sequence_length
535
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen.
uniprot
proteins