EMC4
entrez
51234
canonical
uniprot
Q5J8M3
canonical
ensembl
ENSG00000128463
resolver
ensp
ENSP00000249209
resolver
ensp
ENSP00000267750
resolver
genesymbol
EMC4
resolver
genesymbol
TMEM85
resolver
genesymbol_syn
TMEM85
resolver
hgnc
HGNC:28032
resolver
uniprot
A0A024R9N3
resolver
uniprot
A0A0S2Z598
resolver
uniprot
A8K3A9
resolver
uniprot
B4DJQ4
resolver
uniprot
Q96KX9
resolver
uniprot
Q9BUI5
resolver
uniprot
Q9P0T9
resolver
uniprot_entry
A0A024R9N3_HUMAN
resolver
uniprot_entry
A0A0S2Z598_HUMAN
resolver
uniprot_entry
EMC4_HUMAN
resolver
uniprot_sec
A8K3A9
resolver
uniprot_sec
B4DJQ4
resolver
uniprot_sec
Q96KX9
resolver
uniprot_sec
Q9BUI5
resolver
uniprot_sec
Q9P0T9
resolver
amino_acid_sequence
MTAQGGLVANRGRRFKWAIELSGPGGGSRGRSDRGSGQGDSLYPVGYLDKQVPDTSVQETDRILVEKRCWDIALGPLKQIPMNLFIMYMAGNTISIFPTMMVCMMAWRPIQALMAISATFKMLESSSQKFLQGLVYLIGNLMGLALAVYKCQSMGLLPTHASDWLAFIEPPERMEFSGGGLLL
uniprot
proteins
function
FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29242231, PubMed:29809151, PubMed:30415835, PubMed:32439656, PubMed:32459176). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29242231, PubMed:29809151, PubMed:30415835). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151, PubMed:30415835). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29242231, PubMed:29809151). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). {ECO:0000269|PubMed:29242231, ECO:0000269|PubMed:29809151, ECO:0000269|PubMed:30415835, ECO:0000269|PubMed:32439656, ECO:0000269|PubMed:32459176, ECO:0000305|PubMed:18586032}.
uniprot
proteins
mass_dalton
20087
uniprot
proteins
protein_family
EMC4 family
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18586032
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22119785
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25489052
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29242231
uniprot
proteins
pubmed
29809151
uniprot
proteins
pubmed
30415835
uniprot
proteins
pubmed
32439656
uniprot
proteins
pubmed
32459176
uniprot
proteins
sequence_length
183
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:22119785}; Multi-pass membrane protein {ECO:0000305|PubMed:32439656, ECO:0000305|PubMed:32459176}. Note=Could also be a single-pass transmembrane protein with cytosolic N-terminus and lumenal C-terminus. {ECO:0000305|PubMed:32439656, ECO:0000305|PubMed:32459176}.
uniprot
proteins
transmembrane_region
TRANSMEM 67..87; /note="Helical"; /evidence="ECO:0000305|PubMed:32459176"; TRANSMEM 99..120; /note="Helical"; /evidence="ECO:0000305|PubMed:32459176"; TRANSMEM 128..148; /note="Helical"; /evidence="ECO:0000305|PubMed:32459176
uniprot
proteins