ANKRD13
entrez
88455
canonical
uniprot
Q8IZ07
canonical
ensembl
ENSG00000076513
resolver
ensp
ENSP00000261739
resolver
ensp
ENSP00000577347
resolver
ensp
ENSP00000577348
resolver
ensp
ENSP00000577350
resolver
ensp
ENSP00000609904
resolver
enst
ENST00000261739
resolver
genesymbol
ANKRD13
resolver
genesymbol
ANKRD13A
resolver
genesymbol_syn
ANKRD13
resolver
hgnc
HGNC:21268
resolver
uniprot
O60736
resolver
uniprot
Q3ZTS7
resolver
uniprot
Q9Y5A3
resolver
uniprot_entry
AN13A_HUMAN
resolver
uniprot_entry
Q3ZTS7_HUMAN
resolver
uniprot_entry
Q9Y5A3_HUMAN
resolver
uniprot_sec
O60736
resolver
amino_acid_sequence
MSSACDAGDHYPLHLLVWKNDYRQLEKELQGQNVEAVDPRGRTLLHLAVSLGHLESARVLLRHKADVTKENRQGWTVLHEAVSTGDPEMVYTVLQHRDYHNTSMALEGVPELLQKILEAPDFYVQMKWEFTSWVPLVSRICPNDVCRIWKSGAKLRVDITLLGFENMSWIRGRRSFIFKGEDNWAELMEVNHDDKVVTTERFDLSQEMERLTLDLMKPKSREVERRLTSPVINTSLDTKNIAFERTKSGFWGWRTDKAEVVNGYEAKVYTVNNVNVITKIRTEHLTEEEKKRYKADRNPLESLLGTVEHQFGAQGDLTTECATANNPTAITPDEYFNEEFDLKDRDIGRPKELTIRTQKFKAMLWMCEEFPLSLVEQVIPIIDLMARTSAHFARLRDFIKLEFPPGFPVKIEIPLFHVLNARITFGNVNGCSTAEESVSQNVEGTQADSASHITNFEVDQSVFEIPESYYVQDNGRNVHLQDEDYEIMQFAIQQSLLESSRSQELSGPASNGGISQTNTYDAQYERAIQESLLTSTEGLCPSALSETSRFDNDLQLAMELSAKELEEWELRLQEEEAELQQVLQLSLTDK
uniprot
proteins
function
FUNCTION: Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. {ECO:0000269|PubMed:22298428}.
uniprot
proteins
mass_dalton
67619
uniprot
proteins
mutagenesis
MUTAGEN 491..495; /note="AIQQS->GIQQA: No effect on 'Lys-63'-linked ubiquitin binding and interaction with EGFR. No effect on 'Lys-63'-linked ubiquitin binding and interaction with EGFR; when associated with 527-G--A-531. Inhibits 'Lys-63'-linked ubiquitin binding; when associated with 527-G--A-531 and 557-G--A-561. Abolishes 'Lys-63'-linked ubiquitin binding and interaction with EGFR; when associated with 527-G--A-531, 557-G--A-561 and 582-G--A-586."; /evidence="ECO:0000269|PubMed:22298428"; MUTAGEN 527..531; /note="AIQES->GIQEA: No effect on 'Lys-63'-linked ubiquitin binding and interaction with EGFR. No effect on 'Lys-63'-linked ubiquitin binding and interaction with EGFR; when associated with 491-G--A-495. Inhibits 'Lys-63'-linked ubiquitin binding; when associated with 557-G--A-561. Inhibits 'Lys-63'-linked ubiquitin binding; when associated with 491-G--A-495 and 557-G--A-561. Strongly inhibits 'Lys-63'-linked ubiquitin binding; when associated with 557-G--A-561 and 582-G--A-586. Abolishes 'Lys-63'-linked ubiquitin binding and interaction with EGFR; when associated with 491-G--A-495, 557-G--A-561 and 582-G--A-586."; /evidence="ECO:0000269|PubMed:22298428"; MUTAGEN 557..561; /note="AMELS->GMELA: Slightly inhibits 'Lys-63'-linked ubiquitin binding and strongly inhibits interaction with EGFR. No effect on 'Lys-63'-linked ubiquitin binding and interaction with EGFR; when associated with 527-G--A-531. Inhibits 'Lys-63'-linked ubiquitin binding and interaction with EGFR; when associated with 491-G--A-495 and 527-G--A-531. Abolishes 'Lys-63'-linked ubiquitin binding and interaction with EGFR; when associated with 582-V--S-586. Abolishes 'Lys-63'-linked ubiquitin binding and interaction with EGFR; when associated with 491-G--A-495, 527-G--A-531 and 582-G--A-586."; /evidence="ECO:0000269|PubMed:22298428"; MUTAGEN 582..586; /note="VLQLS->GLQLA: Abolishes 'Lys-63'-linked ubiquitin binding and strongly inhibits interaction with EGFR. Abolishes 'Lys-63'-linked ubiquitin binding and interaction with EGFR; when associated with 557-G--A-561. Strongly inhibits 'Lys-63'-linked ubiquitin binding; when associated with 527-G--A-531 and 557-G--A-561. Abolishes 'Lys-63'-linked ubiquitin binding and interaction with EGFR; when associated with 491-G--A-495, 527-G--A-531 and 557-G--A-561."; /evidence="ECO:0000269|PubMed:22298428
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated, inhibits interaction with ubiquitinated EGFR. {ECO:0000269|PubMed:22298428}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22298428
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
590
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22298428}. Late endosome {ECO:0000269|PubMed:22298428}. Note=Interaction with EGFR may enhance association with the cell membrane.
uniprot
proteins