Rubcn
entrez
100502698
canonical
uniprot
Q80U62
canonical
ensembl
ENSMUSG00000035629
resolver
ensp
ENSMUSP00000048811
resolver
ensp
ENSMUSP00000087114
resolver
ensp
ENSMUSP00000113087
resolver
ensp
ENSMUSP00000316424
resolver
ensp
ENSMUSP00000316425
resolver
ensp
ENSMUSP00000316426
resolver
enst
ENSMUST00000119810
resolver
genesymbol
Rubcn
resolver
genesymbol_syn
1700021K19Rik
resolver
genesymbol_syn
Kiaa0226
resolver
uniprot
D3Z7B1
resolver
uniprot
Q3TAX3
resolver
uniprot
Q3TD96
resolver
uniprot
Q3TDF7
resolver
uniprot
Q3TDU2
resolver
uniprot
Q6NWW8
resolver
uniprot
Q6P9T7
resolver
uniprot
Q6PG18
resolver
uniprot
Q8BMP7
resolver
uniprot
Q8BY22
resolver
uniprot_entry
D3Z7B1_MOUSE
resolver
uniprot_entry
RUBIC_MOUSE
resolver
uniprot_sec
Q3TAX3
resolver
uniprot_sec
Q3TD96
resolver
uniprot_sec
Q3TDF7
resolver
uniprot_sec
Q3TDU2
resolver
uniprot_sec
Q6NWW8
resolver
uniprot_sec
Q6P9T7
resolver
uniprot_sec
Q6PG18
resolver
uniprot_sec
Q8BMP7
resolver
uniprot_sec
Q8BY22
resolver
amino_acid_sequence
MRPEGAGMDLGGGDGERLLEKSRREHWQLLGNLKTTVEGLVSANCPNVWSKYGGLERLCRDMQNILYHGLIHDQVCCRQADYWQFVKDIRWLSPHSALHVEKFISLHESDQSDTDSVSERAVAELWLQHSLQCHCLSAQLRPLLGDRQYIRKFYTETAFLLSDAHVTAMLQCLEAVEQNNPRLLAQIDASMFARKQESPLLVTKSQSLTALPGSTYTPPASYAQHSYFGSSSSLQSMPQSSHSSERRSTSFSLSGPSWQPQEDRECLSPAETQTTPAPLPSDSTLAQDSPLTAQEMSDSTLTSPLEASWVSSQNDSPSDVSEGPEYLAIGNPAPHGRTASCESHSSNGESSSSHLFSSSSSQKLESAASSLGDQEEGRQSQAGSVLRRSSFSEGQTAPVASGTKKSHIRSHSDTNIASRGAAGGPRNITIIVEDPIAEGGQYLCSGEGMFRRPSEGQSLISYLSEQDFGSCADLEKENAHFSISESLIAAIELMKCNMMSQCLEEEEVEEEDSDREIQELKQKIRLRRQQIRTKNLLPAYRETENGSFRVTSSSSQFSSRDSTQLSESGSAEDADDLEIQDADIRRSAVSNGKSSFSQNLSHCFLHSTSAEAVAMGLLKQFEGMQLPAASELEWLVPEHDAPQKLLPIPDSLPISPDDGQHADIYKLRIRVRGNLEWAPPRPQIIFNVHPAPTRKIAVAKQNYRCAGCGIRTDPDYIKRLRYCEYLGKYFCQCCHENAQMVVPSRILRKWDFSKYYVSNFSKDLLLKIWNDPLFNVQDINSALYRKVKLLNQVRLLRVQLYHMKNMFKTCRLAKELLDSFDVVPGHLTEDLHLYSLSDLTATKKGELGPRLAELTRAGAAHVERCMLCQAKGFICEFCQNEEDVIFPFELHKCRTCEECKACYHKTCFKSGRCPRCERLQARRELLAKQSLESYLSDYEEEPTEALALEATVLETT
uniprot
proteins
function
FUNCTION: Inhibits PIK3C3 activity; under basal conditions negatively regulates PI3K complex II (PI3KC3-C2) function in autophagy. Negatively regulates endosome maturation and degradative endocytic trafficking and impairs autophagosome maturation process (PubMed:19270693). Can sequester UVRAG from association with a class C Vps complex (possibly the HOPS complex) and negatively regulates Rab7 activation (By similarity). {ECO:0000250|UniProtKB:Q92622, ECO:0000269|PubMed:19270693}.; FUNCTION: Involved in regulation of pathogen-specific host defense of activated macrophages. Following bacterial infection promotes NADH oxidase activity by association with CYBA thereby affecting TLR2 signaling and probably other TLR-NOX pathways. Stabilizes the CYBA:CYBB NADPH oxidase heterodimer, increases its association with TLR2 and its phagosome trafficking to induce antimicrobial burst of ROS and production of inflammatory cytokines. Following fungal or viral infection (implicating CLEC7A (dectin-1)-mediated myeloid cell activation or RIGI-dependent sensing of RNA viruses) negatively regulates pro-inflammatory cytokine production by association with CARD9 and sequestering it from signaling complexes (By similarity). {ECO:0000250|UniProtKB:Q92622}.
uniprot
proteins
mass_dalton
106860
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19270693
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
956
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome {ECO:0000269|PubMed:19270693}. Lysosome {ECO:0000269|PubMed:19270693}. Early endosome {ECO:0000269|PubMed:19270693}. Note=Predominantly located in late endosomes/lysosomes, only partially detected in early endosome and not at all in the Golgi apparatus.
uniprot
proteins