Cnga3
entrez
85257
canonical
uniprot
Q9ER33
canonical
ensembl
ENSRNOG00000051950
resolver
ensembl
ENSRNOG00055018398
resolver
ensembl
ENSRNOG00060020621
resolver
ensembl
ENSRNOG00065029178
resolver
ensp
ENSRNOP00000074533
resolver
ensp
ENSRNOP00000107668
resolver
enst
ENSRNOT00000081250
resolver
genesymbol
Cnga3
resolver
uniprot
A0A0G2K8A7
resolver
uniprot
A0A0G2KB16
resolver
uniprot
Q9ER32
resolver
uniprot
Q9QWN7
resolver
uniprot_entry
A0A0G2K8A7_RAT
resolver
uniprot_entry
A0A0G2KB16_RAT
resolver
uniprot_entry
CNGA3_RAT
resolver
uniprot_entry
Q9ER32_RAT
resolver
uniprot_sec
Q9QWN7
resolver
activity_regulation
ACTIVITY REGULATION: [Isoform 2]: Inhibited at acidic extracellular pH. Mg(2+) ions inhibit both outward and inward currents in a voltage-dependent way. Inhibited by L-cis-diltiazem. {ECO:0000269|PubMed:11387380, ECO:0000269|PubMed:15178415}.
uniprot
proteins
amino_acid_sequence
MAKVNTQCSQPSPRQLSVKDAADRDLDQVENGLGRSHSPCEETSSTVHQGIVMETGELAGAAQSLFTSQGPARVSRFIISIRAWAARHLHHEDPTPDSFLDRFHGAELKEVSSQERNAQPNPGGQEPPEGGKGRKKDPIVVDPSSNIYYRWLTAIALPVFYNWCLLVCRACFDELQSEHLTLWLVLDYSADALYVVDMLVRARTGFLEQGLMVRDTKRLWKHYTKTLHFKLDILSLIPTDLAYLKLGMNYPELRFNRLLRFSRLFEFFDRTETRTNYPNVFRIGNLVLYTLIIIHWNACIYFAISKFIGFGTDSWVYPNTSKPEYGRLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVIDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANRKTVDEKEVLKNLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPAVFSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMETLTEYPDAKRALEEKGRQILMKDNLIDDDLVTARADARNIEEKVEYLESSLDGLQTRFARLLAEYSASQMKLKQRLSQLESQMTRRGHGFSPDRENSEDASKAD
uniprot
proteins
function
FUNCTION: Pore-forming subunit of the cone cyclic nucleotide-gated channel. Mediates cone photoresponses at bright light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade. Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations. {ECO:0000250|UniProtKB:Q16281, ECO:0000250|UniProtKB:Q29441}.; FUNCTION: [Isoform 2]: Pore-forming subunit of the gustatory cyclic nucleotide-gated channel. In the taste buds, may sense oral extracellular pH and conduct ion currents that modulate the excitability of taste cells. {ECO:0000269|PubMed:11387380, ECO:0000269|PubMed:15178415, ECO:0000269|PubMed:9278419}.
uniprot
proteins
mass_dalton
76420
uniprot
proteins
mutagenesis
MUTAGEN Q9ER33-2:289; /note="E->A: Decreases the pH dependence of cGMP-gated channel conductance."; /evidence="ECO:0000269|PubMed:15178415
uniprot
proteins
protein_family
CNGA3 subfamily
uniprot
proteins
protein_family
Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family
uniprot
proteins
pubmed
11387380
uniprot
proteins
pubmed
11764791
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15178415
uniprot
proteins
pubmed
9278419
uniprot
proteins
sequence_length
670
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Photoreceptor outer segment membrane {ECO:0000250|UniProtKB:Q9JJZ8}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q16281}; Multi-pass membrane protein {ECO:0000255}. Note=Localized in cone outer segment membranes. {ECO:0000250|UniProtKB:Q9JJZ8}.
uniprot
proteins
transmembrane_region
TRANSMEM 153..174; /note="Helical; Name=S1"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 185..205; /note="Helical; Name=S2"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 231..249; /note="Helical; Name=S3"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 255..273; /note="Helical; Name=S4"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 281..304; /note="Helical; Name=S5"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 328..362; /note="Helical; Name=P-helix"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 363..387; /note="Helical; Name=S6"; /evidence="ECO:0000250|UniProtKB:P29973
uniprot
proteins