Tgfbr2
entrez
21813
canonical
uniprot
Q62312
canonical
ensembl
ENSMUSG00000032440
resolver
ensp
ENSMUSP00000035014
resolver
ensp
ENSMUSP00000062333
resolver
genesymbol
Tgfbr2
resolver
uniprot
Q3UG22
resolver
uniprot
Q543C0
resolver
uniprot
Q63947
resolver
uniprot
Q8BQS9
resolver
uniprot_entry
Q3UG22_MOUSE
resolver
uniprot_entry
Q543C0_MOUSE
resolver
uniprot_entry
Q8BQS9_MOUSE
resolver
uniprot_entry
TGFR2_MOUSE
resolver
uniprot_sec
Q63947
resolver
amino_acid_sequence
MGRGLLRGLWPLHIVLWTRIASTIPPHVPKSVNSDVMASDNGGAVKLPQLCKFCDVRLSTCDNQKSCMSNCSITAICEKPHEVCVAVWRKNDKNITLETVCHDPKLTYHGFTLEDAASPKCVMKEKKRAGETFFMCACNMEECNDYIIFSEEYTTSSPDLLLVIIQVTGVSLLPPLGIAIAVIIIFYCYRVHRQQKLSPSWESSKPRKLMDFSDNCAIILEDDRSDISSTCANNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFPYEEYSSWKTEKDIFSDINLKHENILQFLTAEERKTELGKQYWLITAFHAKGNLQEYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPCGRPKMPIVHRDLKSSNILVKNDLTCCLCDFGLSLRLDPTLSVDDLANSGQVGTARYMAPEVLESRMNLENVESFKQTDVYSMALVLWEMTSRCNAVGEVKDYEPPFGSKVREHPCVESMKDSVLRDRGRPEIPSFWLNHQGIQIVCETLTECWDHDPEARLTAQCVAERFSELEHPERLSGRSCSQEKIPEDGSLNTTK
uniprot
proteins
ec_number
2.7.11.30
uniprot
proteins
function
FUNCTION: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways (By similarity). {ECO:0000250|UniProtKB:P37173}.; FUNCTION: [Isoform RII-1]: Has transforming growth factor beta-activated receptor activity. {ECO:0000250|UniProtKB:P37173}.; FUNCTION: [Isoform RII-2]: Has transforming growth factor beta-activated receptor activity. {ECO:0000250|UniProtKB:P37173}.
uniprot
proteins
mass_dalton
64219
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on a Ser/Thr residue in the cytoplasmic domain. {ECO:0000250}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
TGFB receptor subfamily
uniprot
proteins
protein_family
TKL Ser/Thr protein kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7957954
uniprot
proteins
pubmed
8119124
uniprot
proteins
sequence_length
567
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P37173}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P37173}. Membrane raft {ECO:0000250|UniProtKB:P37173}.
uniprot
proteins
transmembrane_region
TRANSMEM 167..187; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins