Dync2i2
entrez
71820
canonical
uniprot
Q5U4F6
canonical
ensembl
ENSMUSG00000039715
resolver
ensp
ENSMUSP00000109340
resolver
enst
ENSMUST00000113711
resolver
genesymbol
Dync2i2
resolver
genesymbol_syn
Wdr34
resolver
uniprot
A2BE91
resolver
uniprot_entry
DC2I2_MOUSE
resolver
uniprot_sec
A2BE91
resolver
amino_acid_sequence
MAMCASPRPFRRVGSAGAAALAAGGAGGAERRGRPAPLQDETLGVASVPSQWRSVQGIRGETKSCQTAGIATAESSAQARTHADAQVQTEAPEEPAAMAPVSQYDTLRLEAFLRRVEAMVIRELNNNWQSHAFDGYEVNWTEQQQTVSCLHTLVYPLAQGQGLHVTGISWNSTGSVLACAYGRLDDGDWSTLKSYVCTWNLDRQGLNPQQPSVVVEVPSAVMCLAFHPTQPSHIAGGLYSGEVLVWDMSRPEDPLLWRTGLTDDTHTDPVYQVLWLPEPRHSHRFQVLSAATDGKVLLWRGSGAGQLRLTKGFALAVQQLPRSTKLKKPPRGETEVGVTSVAFSSFDSSLFVLGTEGGFPLKCSLASEVAALTRMPSSVPLRAPVQFTFSPHGGPVYSVSCSPFHRNLFLSAGTDGHVHLYSMLQAQPLTSLQLSHKYLFAVRWSPVRPLVFAAASGEGDVQLFDLQKSSQKPTVSITQTQDGSPVYCLEFNSQQTQLLAAGDAKGMVKVWQLSTAFTEQGPREVEDLDQLEAEITT
uniprot
proteins
function
FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 2 complex (dynein-2 complex), a motor protein complex that drives the movement of cargos along microtubules within cilia and flagella in concert with the intraflagellar transport (IFT) system. DYNC2I2 plays a major role in retrograde ciliary protein trafficking and in ciliogenesis (PubMed:28379358). Required also to maintain a functional transition zone (By similarity). {ECO:0000250|UniProtKB:Q96EX3, ECO:0000269|PubMed:28379358}.; FUNCTION: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Inhibits the MAP3K7-induced NF-kappa-B activation pathway. Inhibits MAP3K7 phosphorylation at 'Thr-184' and 'Thr-187' upon Il-1 beta stimulation. {ECO:0000250|UniProtKB:Q96EX3}.
uniprot
proteins
mass_dalton
58174
uniprot
proteins
protein_family
Dynein light intermediate chain family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19521662
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24183451
uniprot
proteins
pubmed
28379358
uniprot
proteins
sequence_length
537
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96EX3}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:24183451}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:24183451}. Cell projection, cilium {ECO:0000269|PubMed:28379358}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q96EX3}. Cell projection, filopodium {ECO:0000269|PubMed:28379358}. Note=Concentrates around the centrioles and basal bodies also showing axonemal staining. {ECO:0000269|PubMed:24183451}.
uniprot
proteins