KCNJ16
entrez
3773
canonical
uniprot
Q9NPI9
canonical
ensembl
ENSG00000153822
resolver
ensp
ENSP00000283936
resolver
ensp
ENSP00000376438
resolver
ensp
ENSP00000376439
resolver
ensp
ENSP00000465967
resolver
ensp
ENSP00000479817
resolver
ensp
ENSP00000528919
resolver
ensp
ENSP00000528920
resolver
ensp
ENSP00000528921
resolver
ensp
ENSP00000528922
resolver
ensp
ENSP00000528923
resolver
ensp
ENSP00000528924
resolver
ensp
ENSP00000528925
resolver
ensp
ENSP00000528926
resolver
ensp
ENSP00000528927
resolver
ensp
ENSP00000528928
resolver
ensp
ENSP00000528929
resolver
ensp
ENSP00000528930
resolver
ensp
ENSP00000528931
resolver
ensp
ENSP00000528932
resolver
ensp
ENSP00000528933
resolver
ensp
ENSP00000528934
resolver
ensp
ENSP00000528935
resolver
enst
ENST00000283936
resolver
enst
ENST00000392670
resolver
enst
ENST00000392671
resolver
enst
ENST00000589377
resolver
enst
ENST00000615244
resolver
enst
ENST00000858860
resolver
enst
ENST00000858861
resolver
enst
ENST00000858862
resolver
enst
ENST00000858863
resolver
enst
ENST00000858864
resolver
enst
ENST00000858865
resolver
enst
ENST00000858866
resolver
enst
ENST00000858867
resolver
enst
ENST00000858868
resolver
enst
ENST00000858869
resolver
enst
ENST00000858870
resolver
enst
ENST00000858871
resolver
enst
ENST00000858872
resolver
enst
ENST00000858873
resolver
enst
ENST00000858874
resolver
enst
ENST00000858875
resolver
enst
ENST00000858876
resolver
genesymbol
KCNJ16
resolver
hgnc
HGNC:6262
resolver
uniprot
A8K434
resolver
uniprot
Q8N538
resolver
uniprot_entry
A8K434_HUMAN
resolver
uniprot_entry
KCJ16_HUMAN
resolver
uniprot_entry
Q8N538_HUMAN
resolver
activity_regulation
ACTIVITY REGULATION: Channel activity is strongly regulated by variations of cytosolic pH; channels are activated by alkaline and inhibited by acidic pH values. Activated by phosphatidylinositol 4,5 biphosphate (PtdIns(4,5)P2). {ECO:0000250|UniProtKB:P52191}.
uniprot
proteins
amino_acid_sequence
MSYYGSSYHIINADAKYPGYPPEHIIAEKRRARRRLLHKDGSCNVYFKHIFGEWGSYVVDIFTTLVDTKWRHMFVIFSLSYILSWLIFGSVFWLIAFHHGDLLNDPDITPCVDNVHSFTGAFLFSLETQTTIGYGYRCVTEECSVAVLMVILQSILSCIINTFIIGAALAKMATARKRAQTIRFSYFALIGMRDGKLCLMWRIGDFRPNHVVEGTVRAQLLRYTEDSEGRMTMAFKDLKLVNDQIILVTPVTIVHEIDHESPLYALDRKAVAKDNFEILVTFIYTGDSTGTSHQSRSSYVPREILWGHRFNDVLEVKRKYYKVNCLQFEGSVEVYAPFCSAKQLDWKDQQLHIEKAPPVRESCTSDTKARRRSFSAVAIVSSCENPEETTTSATHEYRETPYQKALLTLNRISVESQM
uniprot
proteins
disease_involvement
DISEASE: Hypokalemic tubulopathy and deafness (HKTD) [MIM:619406]: An autosomal recessive disease characterized by renal tubulopathy with hypokalemia, salt wasting, disturbed acid-base homeostasis, and sensorineural deafness. {ECO:0000269|PubMed:33811157}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ16 may be involved in the regulation of fluid and pH balance. In the kidney, together with KCNJ10, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules (PubMed:24561201). {ECO:0000305|PubMed:24561201}.
uniprot
proteins
mass_dalton
47949
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ16 subfamily
uniprot
proteins
pubmed
11060447
uniprot
proteins
pubmed
11240146
uniprot
proteins
pubmed
24561201
uniprot
proteins
pubmed
33811157
uniprot
proteins
sequence_length
418
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:24561201}; Multi-pass membrane protein. Basolateral cell membrane {ECO:0000269|PubMed:24561201}. Note=In kidney distal convoluted tubules, located in the basolateral membrane in the presence of KCNJ10. {ECO:0000269|PubMed:24561201}.
uniprot
proteins
transmembrane_region
TRANSMEM 68..94; /note="Helical; Name=M1"; /evidence="ECO:0000250|UniProtKB:F1NHE9"; TRANSMEM 144..171; /note="Helical; Name=M2"; /evidence="ECO:0000250|UniProtKB:F1NHE9
uniprot
proteins