Q3V3V9
uniprot
Q3V3V9
canonical
amino_acid_sequence
MAQTPDDISCELRGEITRFLWPKEAELLLKTWLPQEGAEQSHILALLRWRAYLLHTCLPLRVDCTFSYLEVQAMALQETPPRVTFELESLPELVLEFPCVAALEQLAQHVAAAIKKVFPRSTLGKLFRKPTPSSLLARLERSHPLESTIPSSPCGGFLETYEALCDYNGFPFREEIQWDVDTIYHRQGCRHFCLGDFSHFGSRDLALSVAALSYNLWFRRLSCEDMKLSLEVSEQILHMTSQSSYLEELVLEACGLRGDFVRRLAQALAGHFNSGLRELSLSGNLLDDRGMRALGRALATNATFDSTLTHLDLSGNPGALGPSQDSGGLYTFLSRPNVLAYLNLAGTDATLGTLFTALAGGCCSSLTHLEASRNIFSRMKSQAAPAALQRFLGGTRMLRHLGLAGCKLPPEALRALLEGLALNTQIHDLHLDLSACELRSVGAQVIQDLVCDAGALSSLDLSDNGFGSDMVTLVLAIGRSRSLKHVALGRNFNVRCKETLDDVLHRIAQLMQDDDCPLQSLSVAESRLKQGASILIRALGTNPKLTALDISGNAIGDAGAKMLAKALRVNTRLRSVIWDRNNTSALGLLDVAQALEQNHSLKSMPLPLNDVTQAHRSRPELTTRAVHQIQACLWRNNQVDSTSDLKPCLQPLGLISDHSEQEVNELCQSVQEHMELLGCGAGPQGEVAVHQAEDAIQNANFSLSILPILYEAGRSPSHHWQLQQKLESLLGQVGEICRQDIQDFTQTTLDTTRSLCPQMLQTPGWRKQLEGVLVGSGGLPELLPEHLLQDAFSRLRDMRLSITGTLAESIVAQALAGLHAARDRLVERLTQQAPVTMAPAVPPLGGNELSPLETGGLEELFFPTEKEEEREKVLLRKRNGTPSWQLRGKMQSRRLGRLHAVAEKHWAAGPRDTPASAVYQRVDVCVGWVPPALLQEGNGLTARVDEGVEEFFSKRLIQQDHFWAPEEDPATEGGATPVPRTLRKKLGTLFAFKKPRSTRGPRPDLETSPGAAARARKSTLGDLLRPPARPGRGEEPGGAEGGTSSPDPARRNRPRYTRESKAYSMILLPAEEEAAVGTRPDKRRPLERGDTELAPSFEQRVQVMLQRIGVSRASGGAESKRKQSKDGEIKKAGSDGDIMDSSTETPPISIKSRTHSVSADPSCRPGPGGQGPESATWKTLGQQLNAELRGRGWGQQDGPGPPSPCPSPSPRRTSPAPDILSLPEDPCLGPRNEERPLRLQRSPVLKRRPKLEAPPSPSLGSGLGSKPLPPYPTEPSSPERSPPSPATDQRGGGPNP
uniprot
proteins
function
FUNCTION: Cell membrane-cytoskeleton-associated protein that plays a role in the regulation of actin polymerization at the barbed end of actin filaments. Prevents F-actin heterodimeric capping protein (CP) activity at the leading edges of migrating cells, and hence generates uncapped barbed ends and enhances actin polymerization. Plays a role in cell protrusion formations; involved in cell polarity, lamellipodial assembly, membrane ruffling and macropinosome formations. Involved as well in cell migration and invadopodia formation during wound healing (By similarity). Required for CD28-mediated stimulation of NF-kappa-B signaling, involved in naive T cells activation, maturation into T memory cells, and differentiation into T helper cells (PubMed:27647348). Required for CD28-mediated differentiation of T regulatory cells (By similarity). {ECO:0000250|UniProtKB:Q6F5E8, ECO:0000269|PubMed:27647348}.
uniprot
proteins
mass_dalton
141372
uniprot
proteins
protein_family
CARMIL family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
27647348
uniprot
proteins
sequence_length
1296
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6F5E8}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q6F5E8}. Cell membrane {ECO:0000250|UniProtKB:Q6F5E8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6F5E8}; Cytoplasmic side {ECO:0000250|UniProtKB:Q6F5E8}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q6F5E8}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q6F5E8}. Note=Colocalizes to dynamic vimentin filaments both in the central cytoplasm and at leading edges of migrating cells. Colocalizes with F-actin, Arp2/3 complex and cortactin to leading edge lamellipodia, ruffles and macropinosomes of migrating cells. {ECO:0000250|UniProtKB:Q6F5E8}.
uniprot
proteins