Defa6
entrez
13240
canonical
uniprot
P50704
canonical
genesymbol
Defa12
resolver
genesymbol
Defa6
resolver
genesymbol_syn
Defcr12
resolver
genesymbol_syn
Defcr6
resolver
uniprot
P50710
resolver
uniprot
P82294
resolver
uniprot_entry
DEFA6_MOUSE
resolver
uniprot_sec
P50710
resolver
uniprot_sec
P82294
resolver
amino_acid_sequence
MKTLILLSALVLLAFQVQADPIQNTDEETKTEEQPGEEDQAVSVSFGDPEGTSLQEESLRDLVCYCRARGCKGRERMNGTCRKGHLLYMLCCR
uniprot
proteins
function
FUNCTION: Has broad-spectrum antimicrobial properties. Has antibacterial activity against the Gram-positive bacterium L.monocytogenes EGD and the Gram-negative bacteria E.coli ML-35p and avirulent S.typhimurium 7953, but not against the mouse-virulent S.typhimurium 14028S. Probably contributes to the antimicrobial barrier function of the small bowel mucosa. {ECO:0000269|PubMed:1500163, ECO:0000269|PubMed:7927786}.
uniprot
proteins
mass_dalton
10426
uniprot
proteins
protein_family
Alpha-defensin family
uniprot
proteins
pubmed
1500163
uniprot
proteins
pubmed
7927786
uniprot
proteins
pubmed
8188287
uniprot
proteins
sequence_length
93
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins