FCRL5
entrez
83416
canonical
uniprot
Q96RD9
canonical
ensembl
ENSG00000143297
resolver
ensp
ENSP00000354691
resolver
ensp
ENSP00000357172
resolver
ensp
ENSP00000357173
resolver
genesymbol
FCRL5
resolver
genesymbol_syn
FCRH5
resolver
genesymbol_syn
IRTA2
resolver
hgnc
HGNC:18508
resolver
uniprot
A0N0M2
resolver
uniprot
B7WNT9
resolver
uniprot
B7WP94
resolver
uniprot
Q495Q2
resolver
uniprot
Q495Q4
resolver
uniprot
Q5VYK9
resolver
uniprot
Q6UY46
resolver
uniprot_entry
FCRL5_HUMAN
resolver
uniprot_sec
A0N0M2
resolver
uniprot_sec
B7WNT9
resolver
uniprot_sec
B7WP94
resolver
uniprot_sec
Q495Q2
resolver
uniprot_sec
Q495Q4
resolver
uniprot_sec
Q5VYK9
resolver
uniprot_sec
Q6UY46
resolver
amino_acid_sequence
MLLWVILLVLAPVSGQFARTPRPIIFLQPPWTTVFQGERVTLTCKGFRFYSPQKTKWYHRYLGKEILRETPDNILEVQESGEYRCQAQGSPLSSPVHLDFSSASLILQAPLSVFEGDSVVLRCRAKAEVTLNNTIYKNDNVLAFLNKRTDFHIPHACLKDNGAYRCTGYKESCCPVSSNTVKIQVQEPFTRPVLRASSFQPISGNPVTLTCETQLSLERSDVPLRFRFFRDDQTLGLGWSLSPNFQITAMWSKDSGFYWCKAATMPYSVISDSPRSWIQVQIPASHPVLTLSPEKALNFEGTKVTLHCETQEDSLRTLYRFYHEGVPLRHKSVRCERGASISFSLTTENSGNYYCTADNGLGAKPSKAVSLSVTVPVSHPVLNLSSPEDLIFEGAKVTLHCEAQRGSLPILYQFHHEGAALERRSANSAGGVAISFSLTAEHSGNYYCTADNGFGPQRSKAVSLSVTVPVSHPVLTLSSAEALTFEGATVTLHCEVQRGSPQILYQFYHEDMPLWSSSTPSVGRVSFSFSLTEGHSGNYYCTADNGFGPQRSEVVSLFVTVPVSRPILTLRVPRAQAVVGDLLELHCEAPRGSPPILYWFYHEDVTLGSSSAPSGGEASFNLSLTAEHSGNYSCEANNGLVAQHSDTISLSVIVPVSRPILTFRAPRAQAVVGDLLELHCEALRGSSPILYWFYHEDVTLGKISAPSGGGASFNLSLTTEHSGIYSCEADNGLEAQRSEMVTLKVAVPVSRPVLTLRAPGTHAAVGDLLELHCEALRGSPLILYRFFHEDVTLGNRSSPSGGASLNLSLTAEHSGNYSCEADNGLGAQRSETVTLYITGLTANRSGPFATGVAGGLLSIAGLAAGALLLYCWLSRKAGRKPASDPARSPSDSDSQEPTYHNVPAWEELQPVYTNANPRGENVVYSEVRIIQEKKKHAVASDPRHLRNKGSPIIYSEVKVASTPVSGSLFLASSAPHR
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving FCRL5 has been found in cell lines with 1q21 abnormalities derived from Burkitt lymphoma. Duplication dup(1)(q21q32). {ECO:0000269|PubMed:11290337}.
uniprot
proteins
function
FUNCTION: Plays an important role in B-cell response to antigen that acts both as a negative or positive coreceptor. Inhibits B-cell receptor (BCR) signaling in the absence of CR2 stimulation but engagement with CR2 and the BCR lead to a superior calcium response compared to CR2 and BCR costimulation (PubMed:30107486). May be involved in B-cell development and differentiation in peripheral lymphoid organs and may be useful markers of B-cell stages. May have an immunoregulatory role in marginal zone B-cells. May play a role in fertilization (By similarity). {ECO:0000250|UniProtKB:Q68SN8, ECO:0000269|PubMed:11453668}.
uniprot
proteins
mass_dalton
106437
uniprot
proteins
pubmed
11290337
uniprot
proteins
pubmed
11453668
uniprot
proteins
pubmed
11493702
uniprot
proteins
pubmed
11929751
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16849395
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
30107486
uniprot
proteins
sequence_length
977
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16849395}; Single-pass type I membrane protein {ECO:0000269|PubMed:16849395}.
uniprot
proteins
transmembrane_region
TRANSMEM 852..872; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins