Hook1
entrez
77963
canonical
uniprot
Q8BIL5
canonical
ensembl
ENSMUSG00000028572
resolver
ensp
ENSMUSP00000030306
resolver
ensp
ENSMUSP00000238464
resolver
genesymbol
Hook1
resolver
uniprot
Q8BIZ2
resolver
uniprot
Q8K0P1
resolver
uniprot
Q8K454
resolver
uniprot
Q9CTN6
resolver
uniprot_entry
HOOK1_MOUSE
resolver
uniprot_sec
Q8BIZ2
resolver
uniprot_sec
Q8K0P1
resolver
uniprot_sec
Q8K454
resolver
uniprot_sec
Q9CTN6
resolver
amino_acid_sequence
MEDPQPLPQSELPLCDSLIIWLQTFKTASPCQDVKQLTNGVTMAQVLHQIDVAWFSESWLSRIKDDVGDNWRIKASNLKKVLHGITSYYHEFLGQQISEELIPDLNQITECADPVELGRLLQLILGCAVNCEKKQEHIKNIMTLEESVQHVVMTAIQELMSKEIVISPASDTVGELEQQLKRALEELQEAIAEKEELKQRCQELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPNTMVAKKYFHVQLQLEQLQEENYRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETRALKDEIDVLRATSDKANKLESTVEVYRQKLQDLNDLRKQVKSLQETNMMYMHNTVSLEEELKKANAARAQLETYKRQVQDLHTKLSSESKRADTLAFEMKRLEEKHETLLKEKERLIEQRDTLKETNEELRCSKAQQDHLNQADASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQQEGTENERIEQLQEQLEQKHRKMNELETEQRLSKERIGELQQQIEDLQKSLQEQGSKSEGESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDISQNAQKISELEAALQKKDEDMKAMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESECKVAKLRDYEEKLIVSAWYNKSLAFQKLGMESRLVSGASACKDSVAAAPARSFLAQQRHITNTRRNLSVKVPAAASD
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Hook1 are the cause of the azh (abnormal spermatozoon head shape) mutant phenotype, which induces spermatozoa with highly abnormal head morphology that differs drastically from the compact and hook-shaped head of the normal sperm, leading to a strong decrease of fertility. {ECO:0000269|PubMed:12075009}.
uniprot
proteins
function
FUNCTION: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell (By similarity). Required for spermatid differentiation. Probably involved in the positioning of the microtubules of the manchette and the flagellum in relation to the membrane skeleton (PubMed:12075009). {ECO:0000250|UniProtKB:Q9UJC3, ECO:0000269|PubMed:12075009}.
uniprot
proteins
mass_dalton
84439
uniprot
proteins
protein_family
Hook family
uniprot
proteins
pubmed
12075009
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
19091768
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28003339
uniprot
proteins
pubmed
28283191
uniprot
proteins
sequence_length
728
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12075009}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12075009, ECO:0000269|PubMed:28003339}. Note=Localizes to punctate cytoplasmic foci which do not appear to overlap with early or late endosomes, the endoplasmic reticulum, multivesicular bodies (MVBs), lysosomes, or mitochondria (PubMed:12075009). Often found in close association with microtubules (PubMed:12075009). Does not associate with the Golgi complex (PubMed:12075009). During spermiogenesis, it localizes to the manchette in spermatids from steps 8-10 (PubMed:12075009). It is also present between the microtubule manchette and the nucleus (PubMed:12075009). During manchette elongation, it is preferentially localized to the nuclear ring of the manchette, whereas the strong localization to the manchette decreases (PubMed:12075009). In more mature spermatids, while the manchette migrates posteriorly, it localizes to punctuates spots (PubMed:12075009). At later stages of spermatid differentiation, the punctuate expression pattern is found at both the attachment site and the proximal end of the elongated manchette (PubMed:12075009). In contrast, it is not present in mature spermatozoa (PubMed:12075009). {ECO:0000269|PubMed:12075009}.
uniprot
proteins