Cybrd1
entrez
73649
canonical
uniprot
Q925G2
canonical
ensembl
ENSMUSG00000027015
resolver
ensp
ENSMUSP00000028403
resolver
genesymbol
Cybrd1
resolver
genesymbol_syn
Dcytb
resolver
uniprot
A2AUU8
resolver
uniprot
Q9D7U1
resolver
uniprot_entry
CYBR1_MOUSE
resolver
uniprot_sec
A2AUU8
resolver
uniprot_sec
Q9D7U1
resolver
amino_acid_sequence
MAMEGYRGFLGLLVSALLVGFLSVIFVLIWVLHFREGLGWNGSGLEFNWHPVLAVTGFVFIQGIAIIVYRLPWTWKCSKLLMKSIHAGLNAVAAILAIISVVAVFEYHNVQKVPHMYSLHSWVGLTALILYIQQLVVGFFVFLLPWAPPSLRAIVMPIHVYSGLLLFGTVIATVLMGVTEKLFFVLKHPSYHSFPPEGVFTNTLGLLILVFGALIFWIVTRPQWKRPREPGSVPLQLNGGNAECRMEGAIAISSAHSMDAADPADAESSSEGAARKRTLGLADSGQRSTM
uniprot
proteins
ec_number
7.2.1.3
uniprot
proteins
function
FUNCTION: Plasma membrane reductase that uses cytoplasmic ascorbate as an electron donor to reduce extracellular Fe(3+) into Fe(2+) (PubMed:17068337). Probably functions in dietary iron absorption at the brush border of duodenal enterocytes by producing Fe(2+), the divalent form of iron that can be transported into enterocytes (PubMed:11230685, PubMed:12547225). It is also able to reduce extracellular monodehydro-L-ascorbate and may be involved in extracellular ascorbate regeneration by erythrocytes in blood (PubMed:17068337). May also act as a ferrireductase in airway epithelial cells (By similarity). May also function as a cupric transmembrane reductase (PubMed:18498772). {ECO:0000250|UniProtKB:Q53TN4, ECO:0000269|PubMed:11230685, ECO:0000269|PubMed:12547225, ECO:0000269|PubMed:17068337, ECO:0000269|PubMed:18498772}.
uniprot
proteins
mass_dalton
31844
uniprot
proteins
pubmed
11230685
uniprot
proteins
pubmed
12377801
uniprot
proteins
pubmed
12547225
uniprot
proteins
pubmed
12704390
uniprot
proteins
pubmed
15961514
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16326980
uniprot
proteins
pubmed
17068337
uniprot
proteins
pubmed
18498772
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
290
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q53TN4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q53TN4}. Apical cell membrane {ECO:0000305|PubMed:11230685, ECO:0000305|PubMed:12547225}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q53TN4}. Note=Localized at the brush border of duodenal cells. {ECO:0000269|PubMed:11230685, ECO:0000269|PubMed:12547225}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..32; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q53TN4"; TRANSMEM 48..69; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q53TN4"; TRANSMEM 79..105; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q53TN4"; TRANSMEM 119..144; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q53TN4"; TRANSMEM 152..179; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q53TN4"; TRANSMEM 198..222; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q53TN4
uniprot
proteins