Aktip
entrez
14339
canonical
uniprot
Q64362
canonical
ensembl
ENSMUSG00000031667
resolver
ensp
ENSMUSP00000105238
resolver
ensp
ENSMUSP00000112375
resolver
ensp
ENSMUSP00000113379
resolver
ensp
ENSMUSP00000113769
resolver
ensp
ENSMUSP00000119277
resolver
ensp
ENSMUSP00000198898
resolver
ensp
ENSMUSP00000198899
resolver
ensp
ENSMUSP00000198906
resolver
ensp
ENSMUSP00000198907
resolver
ensp
ENSMUSP00000198908
resolver
ensp
ENSMUSP00000198909
resolver
ensp
ENSMUSP00000198910
resolver
ensp
ENSMUSP00000198911
resolver
ensp
ENSMUSP00000198921
resolver
ensp
ENSMUSP00000198931
resolver
ensp
ENSMUSP00000198932
resolver
ensp
ENSMUSP00000198933
resolver
ensp
ENSMUSP00000348129
resolver
enst
ENSMUST00000109609
resolver
enst
ENSMUST00000120213
resolver
enst
ENSMUST00000120349
resolver
enst
ENSMUST00000120426
resolver
enst
ENSMUST00000125257
resolver
genesymbol
Aktip
resolver
genesymbol_syn
Fif
resolver
genesymbol_syn
Ft1
resolver
genesymbol_syn
Fts
resolver
uniprot
D3Z632
resolver
uniprot
Q05BP5
resolver
uniprot
Q3TYE3
resolver
uniprot_entry
AKTIP_MOUSE
resolver
uniprot_entry
D3Z632_MOUSE
resolver
uniprot_entry
Q05BP5_MOUSE
resolver
uniprot_sec
Q3TYE3
resolver
amino_acid_sequence
MNPLWSMSAGSVRKRAEGEEKTLAGDVKTSPPRSAPKKQLPSIPKNALPIAKPTSPAPAAQSTNGTHASYGPFYLEYSLLAEFTLVVKQKLPGVYVQPSYRSALVWFGVIFIRHGLYQDGVFKFTVYIPDNYPDGDCPRLLFDIPVFHPLVDPTSGELDVKRAFAKWRRNHNHIWQVLMYARRVFYKIDTTSPLNPEAAVLYEKDIQLFKSKVVDSVKVCTARLFDQPKIEDPYAISFSPWNPSVHDEAREKMLTQKKPDEQHNKSVHVAGLSWVKPGSVQPFSKEEKTVAT
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Aktip are a cause of embryonic death in homozygous animals. Death occurs at about 10 days of development. Symptoms include loss of left-right asymmetry, malformation of the developing brain and of the spinal cord, syndactyly and polydactyly. Heterozygous animals are characterized by polydactyly and thymic hyperplasia. {ECO:0000269|PubMed:7956835}.
uniprot
proteins
function
FUNCTION: Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). Regulates apoptosis by enhancing phosphorylation and activation of AKT1. Increases release of TNFSF6 via the AKT1/GSK3B/NFATC1 signaling cascade. FHF complex promotes the distribution of AP-4 complex to the perinuclear area of the cell. {ECO:0000250|UniProtKB:Q9H8T0}.
uniprot
proteins
mass_dalton
32942
uniprot
proteins
protein_family
FTS subfamily
uniprot
proteins
protein_family
Ubiquitin-conjugating enzyme family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7956835
uniprot
proteins
pubmed
9383278
uniprot
proteins
sequence_length
292
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H8T0}. Cell membrane {ECO:0000250|UniProtKB:Q9H8T0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9H8T0}.
uniprot
proteins