Terf2ip
entrez
307861
canonical
uniprot
Q5EAN7
canonical
ensembl
ENSRNOG00000010712
resolver
ensp
ENSRNOP00000014660
resolver
genesymbol
Terf2ip
resolver
genesymbol_syn
Rap1
resolver
uniprot_entry
TE2IP_RAT
resolver
amino_acid_sequence
MAEVMDLGKDPNGPTHSSTLFVREDGSAMSFYVRPSSAKRRLSTLILHGGGILCRVQKPGAVLLAQPGEALAEASGDFISTQYILDCVERNEKLELEAYRLGLTEQASDPKPGASAEGSTEPEPQPLTGRIAYTDADDVAILTYVKENARSPSSVTGNALWKAMEKSSLTQHSWQSLKDRYLKHLQGQEHKYLLGNAPVSPSSQKLKRKAEQDPEAADSGEPQNKRTPDLPEEECVKGETKENGEADNKLFEEATPELGEAVVDESPDFEIHITMCDGDPPTPEEDSETQPDEEEEEPKVSTQEVGTAIKIIRQLMEKFNLDLSTVTQALLKNSGELEATSSFLESGRRPDGFPIWCRQDDLDLQKDDDDTRNALVKKYGAQNVARRIEFRKK
uniprot
proteins
function
FUNCTION: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
43418
uniprot
proteins
protein_family
RAP1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
393
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q91VL8}. Cytoplasm {ECO:0000250|UniProtKB:Q91VL8}. Chromosome {ECO:0000250|UniProtKB:Q91VL8}. Chromosome, telomere {ECO:0000250|UniProtKB:Q91VL8}. Note=Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex. {ECO:0000250|UniProtKB:Q91VL8}.
uniprot
proteins