Map1lc3a
entrez
66734
canonical
uniprot
Q91VR7
canonical
ensembl
ENSMUSG00000027602
resolver
ensp
ENSMUSP00000029128
resolver
enst
ENSMUST00000029128
resolver
genesymbol
Map1lc3a
resolver
uniprot
A2AVS1
resolver
uniprot
Q9DC74
resolver
uniprot_entry
MLP3A_MOUSE
resolver
uniprot_sec
A2AVS1
resolver
uniprot_sec
Q9DC74
resolver
amino_acid_sequence
MPSDRPFKQRRSFADRCKEVQQIRDQHPSKIPVIIERYKGEKQLPVLDKTKFLVPDHVNMSELVKIIRRRLQLNPTQAFFLLVNQHSMVSVSTPIADIYEQEKDEDGFLYMVYASQETFGF
uniprot
proteins
function
FUNCTION: Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover. {ECO:0000250|UniProtKB:Q9H492}.
uniprot
proteins
mass_dalton
14272
uniprot
proteins
post_translational_modification
PTM: The precursor molecule is cleaved by ATG4 (ATG4A, ATG4B, ATG4C or ATG4D) to expose the glycine at the C-terminus and form the cytosolic form, LC3-I (PubMed:12207896, PubMed:14530254). The processed form is then activated by APG7L/ATG7, transferred to ATG3 and conjugated to phosphatidylethanolamine (PE) phospholipid to form the membrane-bound form, LC3-II (By similarity). During non-canonical autophagy, the processed form is conjugated to phosphatidylserine (PS) phospholipid (By similarity). ATG4 proteins also mediate the delipidation of PE-conjugated forms (PubMed:33795848). In addition, ATG4B and ATG4D mediate delipidation of ATG8 proteins conjugated to PS during non-canonical autophagy (By similarity). ATG4B constitutes the major protein for proteolytic activation (By similarity). ATG4D is the main enzyme for delipidation activity (PubMed:33795848). {ECO:0000250|UniProtKB:Q9H492, ECO:0000269|PubMed:12207896, ECO:0000269|PubMed:14530254, ECO:0000269|PubMed:33795848}.; PTM: Phosphorylation at Ser-12 by PKA inhibits conjugation to phosphatidylethanolamine (PE). {ECO:0000250|UniProtKB:Q9H492}.
uniprot
proteins
protein_family
ATG8 family
uniprot
proteins
pubmed
11266458
uniprot
proteins
pubmed
12207896
uniprot
proteins
pubmed
14530254
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
33795848
uniprot
proteins
pubmed
34338405
uniprot
proteins
sequence_length
121
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endomembrane system {ECO:0000269|PubMed:14530254}; Lipid-anchor {ECO:0000250|UniProtKB:Q9H492}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:11266458, ECO:0000269|PubMed:12207896}; Lipid-anchor {ECO:0000250|UniProtKB:Q9H492}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:Q9H492}. Cytoplasm, cytoskeleton {ECO:0000305|PubMed:14530254}. Note=LC3-II binds to the autophagic membranes. {ECO:0000250|UniProtKB:Q9H492}.
uniprot
proteins