Slc39a7
entrez
14977
canonical
uniprot
Q31125
canonical
ensembl
ENSMUSG00000024327
resolver
ensp
ENSMUSP00000025186
resolver
ensp
ENSMUSP00000130102
resolver
enst
ENSMUST00000025186
resolver
enst
ENSMUST00000169397
resolver
genesymbol
Slc39a7
resolver
genesymbol_syn
H2-Ke4
resolver
genesymbol_syn
Hke4
resolver
uniprot
A0A068BIT0
resolver
uniprot
Q3TVU6
resolver
uniprot
Q9Z1W1
resolver
uniprot_entry
A0A068BIT0_MOUSE
resolver
uniprot_entry
S39A7_MOUSE
resolver
uniprot_sec
Q3TVU6
resolver
uniprot_sec
Q9Z1W1
resolver
amino_acid_sequence
MTMGLRAPHWVAVGLLTWAALGLLVAGHEGHGDLHKDVEEDFHGHSHGHSHEDFHHGHSHGHSHEDFHHGHGHTHESIWHGHAHSHDHGHSREELHHGHSHGHSHDSLHHGGHGHAHREHSHGTSREAGAPGIKHHLDTVTLWAYALGATVLISAAPFFVLFLIPVESNSPRHRSLLQILLSFASGGLLGDAFLHLIPHALEPHSHHAPEQPGHGHSHSGQGPILSVGLWVLSGIVAFLVVEKFVRHVKGGHGHSHGHGDRHAHGDSHTHGDRHECSSKEKPSTEEEKEVGGLRKRRGGNTGPRDGPVKPQSPEEEKAGSDLRVSGYLNLAADLAHNFTDGLAIGASFRGGRGLGILTTMTVLLHEVPHEVGDFAILVQSGCSKKQAMRLQLVTAIGALAGTACALLTEGGAVDSDVAGGAGPGWVLPFTAGGFIYVATVSVLPELLREASPLQSLLEVLGLLGGVAMMVLIAHLE
uniprot
proteins
function
FUNCTION: Transports Zn(2+) from the endoplasmic reticulum (ER)/Golgi apparatus to the cytosol, playing an essential role in the regulation of cytosolic zinc levels (PubMed:15705588). Acts as a gatekeeper of zinc release from intracellular stores, requiring post-translational activation by phosphorylation, resulting in activation of multiple downstream pathways leading to cell growth and proliferation (By similarity). Has an essential role in B cell development and is required for proper B cell receptor signaling (PubMed:30718914). Plays an important role in maintaining intestinal epithelial homeostasis and skin dermis development by regulating ER function (PubMed:27736879, PubMed:28545780). Controls cell signaling pathways involved in glucose metabolism in skeletal muscle (PubMed:31266232). Has a protective role against ER stress in different biological contexts (PubMed:31266232). Mediates Zn(2+)-induced ferroptosis (By similarity). {ECO:0000250|UniProtKB:Q92504, ECO:0000269|PubMed:15705588, ECO:0000269|PubMed:27736879, ECO:0000269|PubMed:28545780, ECO:0000269|PubMed:30718914, ECO:0000269|PubMed:31266232}.
uniprot
proteins
mass_dalton
50657
uniprot
proteins
mutagenesis
MUTAGEN 73; /note="H->A: Abolished METTL9-mediated methylation."; /evidence="ECO:0000269|PubMed:34218407"; MUTAGEN 75; /note="H->A: Abolished METTL9-mediated methylation."; /evidence="ECO:0000269|PubMed:34218407"; MUTAGEN 198; /note="P->A: Homozygous mice have profound B cell immunodeficiency and impaired transition from late pre-B to immature B cell. B cells from mutant mice exhibit a diminished concentration of cytoplasmic free zinc and decreased phosphorylation of signaling molecules downstream of the pre-B cell and B cell receptors."; /evidence="ECO:0000269|PubMed:30718914"; MUTAGEN 204; /note="H->A: Decreased METTL9-mediated methylation; when associated with A-216."; /evidence="ECO:0000269|PubMed:34218407"; MUTAGEN 216; /note="H->A: Decreased METTL9-mediated methylation; when associated with A-204."; /evidence="ECO:0000269|PubMed:34218407"; MUTAGEN 254; /note="H->A: Decreased METTL9-mediated methylation; when associated with A-262."; /evidence="ECO:0000269|PubMed:34218407"; MUTAGEN 262; /note="H->A: Decreased METTL9-mediated methylation; when associated with A-254."; /evidence="ECO:0000269|PubMed:34218407
uniprot
proteins
post_translational_modification
PTM: Methylation at some His residue by METTL9 leads to reduced zinc-binding. {ECO:0000269|PubMed:34218407}.; PTM: Rapidly phosphorylated by CK2 following Zn(2+) treatment. This phosphorylation is required for efficient cytosolic Zn(2+) release. {ECO:0000250|UniProtKB:Q92504}.
uniprot
proteins
protein_family
KE4/Catsup subfamily
uniprot
proteins
protein_family
ZIP transporter (TC 2.A.5) family
uniprot
proteins
pubmed
15705588
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2294398
uniprot
proteins
pubmed
27736879
uniprot
proteins
pubmed
28545780
uniprot
proteins
pubmed
30718914
uniprot
proteins
pubmed
31266232
uniprot
proteins
pubmed
34218407
uniprot
proteins
sequence_length
476
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q92504}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q92504}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..27; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 146..166; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 177..197; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 222..242; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 393..413; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 417..437; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins