Inhibition of host poly(A)-binding protein by virus
uniprot_keyword
KW-1101
canonical
name
Inhibition of host poly(A)-binding protein by virus
uniprot
definition
Viral protein involved in the inhibition of host translation by inhibiting the poly(A)-binding protein PABPC1. Viruses have evolved ways of interacting with the host translational machinery to shutoff host gene expression. This global inhibition of cellular protein synthesis serves to ensure maximal viral gene expression and to evade host immune response. One common target is the translation initiation factor PABPC1. Some viruses proteolytically cleave PABPC1, while others displace PABPC1 from EIF4G1.
uniprot
keywords
is_obsolete
false
uniprot
keywords
ontology_id
uniprot_keywords
uniprot
keywords