Iyd
entrez
70337
canonical
uniprot
Q9DCX8
canonical
ensembl
ENSMUSG00000019762
resolver
ensp
ENSMUSP00000019896
resolver
enst
ENSMUST00000019896
resolver
genesymbol
Iyd
resolver
genesymbol_syn
Dehal1
resolver
uniprot_entry
IYD1_MOUSE
resolver
amino_acid_sequence
MFLLTPVLVAVVCILVVWVFKNADRNLEKKKEEAQVQPWVDEDLKDSTEDLQVEEDAEEWQEAEESVEHIPFSHTRYPEQEMRMRSQEFYELLNKRRSVRFISSEHVPMEVIENVIKAAGTAPSGAHTEPWTFVVVKDPDMKHKIREIIEEEEEINYMKRMGKRWVTDLKKLRTNWIKEYLDTAPVLILIFKQVHGFAANGKKKVHYYNEISVSIACGLLLAALQNAGLVTVTTTPLNCGPRLRVLLGRPSHEKLLVLLPVGYPSRDATVPDLKRKALDQIMVTV
uniprot
proteins
ec_number
1.21.1.1
uniprot
proteins
function
FUNCTION: Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine (By similarity). During thyroid hormone biosynthesis, facilitates iodide salvage by catalysing the oxidative NADPH-dependent deiodination of the halogenated by-products of thyroid hormone production, monoiodotyrosine (L-MIT) and diiodotyrosine (L-DIT) (PubMed:22238141). The scavanged iodide can then reenter the hormone-producing pathways (By similarity). Acts more efficiently on 3-iodo-L-tyrosine than 3,5-diiodo-L-tyrosine (By similarity). {ECO:0000250|UniProtKB:Q6PHW0, ECO:0000269|PubMed:22238141}.
uniprot
proteins
mass_dalton
32814
uniprot
proteins
mutagenesis
MUTAGEN 153; /note="E->Q: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:22238141
uniprot
proteins
protein_family
Nitroreductase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19436071
uniprot
proteins
pubmed
19777994
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22238141
uniprot
proteins
sequence_length
285
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6PHW0}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q6PHW0}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q6PHW0}.
uniprot
proteins
transmembrane_region
TRANSMEM 1..21; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins