FGF9
entrez
2254
canonical
uniprot
P31371
canonical
ensembl
ENSG00000102678
resolver
ensp
ENSP00000371790
resolver
enst
ENST00000382353
resolver
genesymbol
FGF9
resolver
hgnc
HGNC:3687
resolver
uniprot
A8K427
resolver
uniprot
Q3SY32
resolver
uniprot_entry
FGF9_HUMAN
resolver
uniprot_sec
A8K427
resolver
uniprot_sec
Q3SY32
resolver
amino_acid_sequence
MAPLGEVGNYFGVQDAVPFGNVPVLPVDSPVLLSDHLGQSEAGGLPRGPAVTDLDHLKGILRRRQLYCRTGFHLEIFPNGTIQGTRKDHSRFGILEFISIAVGLVSIRGVDSGLYLGMNEKGELYGSEKLTQECVFREQFEENWYNTYSSNLYKHVDTGRRYYVALNKDGTPREGTRTKRHQKFTHFLPRPVDPDKVPELYKDILSQS
uniprot
proteins
disease_involvement
DISEASE: Multiple synostoses syndrome 3 (SYNS3) [MIM:612961]: A bone disease characterized by multiple progressive joint fusions that commonly involve proximal interphalangeal, tarsal-carpal, humeroradial and cervical spine joints. Additional features can include progressive conductive deafness and facial dysmorphism. {ECO:0000269|PubMed:19589401}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors. {ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:8663044}.
uniprot
proteins
mass_dalton
23441
uniprot
proteins
post_translational_modification
PTM: Three molecular species were found (30 kDa, 29 kDa and 25 kDa), cleaved at Leu-4, Val-13 and Ser-34 respectively. The smaller ones might be products of proteolytic digestion. Furthermore, there may be a functional signal sequence in the 30 kDa species which is uncleavable in the secretion step.; PTM: N-glycosylated.
uniprot
proteins
protein_family
Heparin-binding growth factors family
uniprot
proteins
pubmed
11060292
uniprot
proteins
pubmed
11223514
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16597617
uniprot
proteins
pubmed
19589401
uniprot
proteins
pubmed
20094046
uniprot
proteins
pubmed
8321227
uniprot
proteins
pubmed
8428960
uniprot
proteins
pubmed
8663044
uniprot
proteins
sequence_length
208
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins