Cx3cr1
entrez
13051
canonical
uniprot
Q9Z0D9
canonical
ensembl
ENSMUSG00000052336
resolver
ensp
ENSMUSP00000063986
resolver
ensp
ENSMUSP00000150463
resolver
enst
ENSMUST00000064165
resolver
enst
ENSMUST00000215016
resolver
genesymbol
Cx3cr1
resolver
uniprot
Q543X3
resolver
uniprot_entry
CX3C1_MOUSE
resolver
uniprot_entry
Q543X3_MOUSE
resolver
amino_acid_sequence
MSTSFPELDLENFEYDDSAEACYLGDIVAFGTIFLSVFYALVFTFGLVGNLLVVLALTNSRKPKSITDIYLLNLALSDLLFVATLPFWTHYLISHEGLHNAMCKLTTAFFFIGFFGGIFFITVISIDRYLAIVLAANSMNNRTVQHGVTISLGVWAAAILVASPQFMFTKRKDNECLGDYPEVLQEMWPVLRNSEVNILGFALPLLIMSFCYFRIIQTLFSCKNRKKARAVRLILLVVFAFFLFWTPYNIMIFLETLKFYNFFPSCDMKRDLRLALSVTETVAFSHCCLNPFIYAFAGEKFRRYLGHLYRKCLAVLCGHPVHTGFSPESQRSRQDSILSSFTHYTSEGDGSLLL
uniprot
proteins
function
FUNCTION: Receptor for the C-X3-C chemokine fractalkine (CX3CL1) present on many early leukocyte cells; CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis (PubMed:10187784, PubMed:9918795). CX3CR1-CX3CL1 signaling mediates cell migratory functions (PubMed:11544273, PubMed:12871640, PubMed:16675847, PubMed:18322241). Responsible for the recruitment of natural killer (NK) cells to inflamed tissues (PubMed:11544273, PubMed:16675847). Acts as a regulator of inflammation process leading to atherogenesis by mediating macrophage and monocyte recruitment to inflamed atherosclerotic plaques, promoting cell survival (PubMed:12569158, PubMed:18971423). Involved in airway inflammation by promoting interleukin 2-producing T helper (Th2) cell survival in inflamed lung (PubMed:21037587). Involved in the migration of circulating monocytes to non-inflamed tissues, where they differentiate into macrophages and dendritic cells (PubMed:12871640). Acts as a negative regulator of angiogenesis, probably by promoting macrophage chemotaxis (PubMed:18322241). Plays a key role in brain microglia by regulating inflammatory response in the central nervous system (CNS) and regulating synapse maturation (PubMed:16732273, PubMed:21778362, PubMed:24487234). Required to restrain the microglial inflammatory response in the CNS and the resulting parenchymal damage in response to pathological stimuli (PubMed:16732273). Involved in brain development by participating in synaptic pruning, a natural process during which brain microglia eliminates extra synapses during postnatal development (PubMed:21778362). Synaptic pruning by microglia is required to promote the maturation of circuit connectivity during brain development (PubMed:24487234). Acts as an important regulator of the gut microbiota by controlling immunity to intestinal bacteria and fungi (PubMed:15653504, PubMed:29326275). Expressed in lamina propria dendritic cells in the small intestine, which form transepithelial dendrites capable of taking up bacteria in order to provide defense against pathogenic bacteria (PubMed:15653504). Required to initiate innate and adaptive immune responses against dissemination of commensal fungi (mycobiota) component of the gut: expressed in mononuclear phagocytes (MNPs) and acts by promoting induction of antifungal IgG antibodies response to confer protection against disseminated C.albicans or C.auris infection (PubMed:29326275, PubMed:33548172). Also acts as a receptor for C-C motif chemokine CCL26, inducing cell chemotaxis (By similarity). {ECO:0000250|UniProtKB:P49238, ECO:0000269|PubMed:10187784, ECO:0000269|PubMed:11544273, ECO:0000269|PubMed:12569158, ECO:0000269|PubMed:12871640, ECO:0000269|PubMed:15653504, ECO:0000269|PubMed:16675847, ECO:0000269|PubMed:16732273, ECO:0000269|PubMed:18322241, ECO:0000269|PubMed:18971423, ECO:0000269|PubMed:21037587, ECO:0000269|PubMed:21778362, ECO:0000269|PubMed:24487234, ECO:0000269|PubMed:29326275, ECO:0000269|PubMed:33548172, ECO:0000269|PubMed:9918795}.
uniprot
proteins
mass_dalton
40266
uniprot
proteins
mutagenesis
MUTAGEN 127..128; /note="DR->NN: In DR/NN; abolished activity without affecting avility to bind CX3CL1."; /evidence="ECO:0000269|PubMed:10187784"; MUTAGEN 128; /note="R->N: Abolished activity without affecting avility to bind CX3CL1."; /evidence="ECO:0000269|PubMed:10187784
uniprot
proteins
post_translational_modification
PTM: This protein is not N-glycosylated which is unusual for G protein-coupled receptors. {ECO:0000250|UniProtKB:P35411}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10187784
uniprot
proteins
pubmed
10805752
uniprot
proteins
pubmed
11544273
uniprot
proteins
pubmed
12569158
uniprot
proteins
pubmed
12871640
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15653504
uniprot
proteins
pubmed
16675847
uniprot
proteins
pubmed
16732273
uniprot
proteins
pubmed
18322241
uniprot
proteins
pubmed
18971423
uniprot
proteins
pubmed
21037587
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21778362
uniprot
proteins
pubmed
24487234
uniprot
proteins
pubmed
29326275
uniprot
proteins
pubmed
33548172
uniprot
proteins
pubmed
9918795
uniprot
proteins
sequence_length
354
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10187784}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 33..60; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 71..91; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 105..126; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 144..168; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 197..216; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 233..257; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 275..298; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins