Ppil2
entrez
66053
canonical
uniprot
Q9D787
canonical
ensembl
ENSMUSG00000022771
resolver
ensp
ENSMUSP00000023455
resolver
ensp
ENSMUSP00000131422
resolver
ensp
ENSMUSP00000155861
resolver
ensp
ENSMUSP00000324435
resolver
ensp
ENSMUSP00000324491
resolver
enst
ENSMUST00000023455
resolver
enst
ENSMUST00000164458
resolver
enst
ENSMUST00000231712
resolver
genesymbol
Ppil2
resolver
uniprot
Q542A2
resolver
uniprot
Q9CZL1
resolver
uniprot_entry
PPIL2_MOUSE
resolver
uniprot_sec
Q542A2
resolver
uniprot_sec
Q9CZL1
resolver
amino_acid_sequence
MGKRQHQKDKMYITCAEYTHFYGGRKPDISQTSFRRLPFDHCSLSLQPFVYPVCTPEGVVFDLLNIVPWLKKYGTNPSTGEKLDGKSLIKLNFAKNSEGQYHCPVLYSVFTDNTHIVAIRTTGNVYTYEAVEQLNIKAKNLRDLLTDEPFSRQDIITLQDPTNLDKFNVSNFFHVKNNMRIIDPDEEKAKQDPSYYLKNTNSETRETLQELYKEFKGDEILAATMRPPEKKKVDQLNAAHYSTGKVSASFTSTAMVPETTHEAAVIDEDVLRYQFVKKKGYVRLHTNKGDLNLELHCDLTPKTCENFIKLCKKQYYDGTIFHRSIRNFVIQGGDPTGTGTGGESFWGKPFKDEFRPNLSHTGRGVLSMANSGPNTNKSQFFITFRSCAYLDKKHTIFGRVVGGFDTLTAMENVESDPKTDRPKEEVLICTTTVFVDPYEEADAQIAQERKKTQHQVDPEAKVKMSQPQPGNQGPQTYRQGVGKYIHPAATKRSAEEEPSTSTATPTAKKRPSRGFGDFSSW
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation. May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance. Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (By similarity). {ECO:0000250|UniProtKB:Q13356}.
uniprot
proteins
mass_dalton
59065
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q13356}.
uniprot
proteins
protein_family
Cyclophilin-type PPIase family
uniprot
proteins
protein_family
PPIL2 subfamily
uniprot
proteins
pubmed
15189447
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
521
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13356}.
uniprot
proteins