Csnk1d
entrez
104318
canonical
uniprot
Q9DC28
canonical
ensembl
ENSMUSG00000025162
resolver
ensp
ENSMUSP00000018274
resolver
ensp
ENSMUSP00000070721
resolver
ensp
ENSMUSP00000158953
resolver
ensp
ENSMUSP00000216380
resolver
ensp
ENSMUSP00000216381
resolver
ensp
ENSMUSP00000216397
resolver
enst
ENSMUST00000239115
resolver
genesymbol
Csnk1d
resolver
genesymbol_syn
Hckid
resolver
uniprot
A0A5F8MPF4
resolver
uniprot
Q3TZK2
resolver
uniprot
Q3UBT6
resolver
uniprot
Q3USK2
resolver
uniprot
Q99KK4
resolver
uniprot_entry
A0A5F8MPF4_MOUSE
resolver
uniprot_entry
KC1D_MOUSE
resolver
uniprot_entry
Q3UBT6_MOUSE
resolver
uniprot_entry
Q3USK2_MOUSE
resolver
uniprot_sec
Q3TZK2
resolver
uniprot_sec
Q99KK4
resolver
activity_regulation
ACTIVITY REGULATION: Exhibits substrate-dependent heparin activation. Drug-mediated inhibition leads to a delay of the oscillations with the magnitude of this effect dependent upon the timing of drug administration. Inhibited by phosphorylation (By similarity). {ECO:0000250|UniProtKB:P48730}.
uniprot
proteins
amino_acid_sequence
MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNVSSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
ec_number
2.7.11.26
uniprot
proteins
function
FUNCTION: Essential serine/threonine-protein kinase that regulates diverse cellular growth and survival processes including Wnt signaling, DNA repair and circadian rhythms. It can phosphorylate a large number of proteins. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates connexin-43/GJA1, MAP1A, SNAPIN, MAPT/TAU, TOP2A, DCK, HIF1A, EIF6, p53/TP53, DVL2, DVL3, ESR1, AIB1/NCOA3, DNMT1, PKD2, YAP1, PER1 and PER2. Central component of the circadian clock. In balance with PP1, determines the circadian period length through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. YAP1 phosphorylation promotes its SCF(beta-TRCP) E3 ubiquitin ligase-mediated ubiquitination and subsequent degradation. DNMT1 phosphorylation reduces its DNA-binding activity. Phosphorylation of ESR1 and AIB1/NCOA3 stimulates their activity and coactivation. Phosphorylation of DVL2 and DVL3 regulates WNT3A signaling pathway that controls neurite outgrowth. Phosphorylates NEDD9/HEF1 (PubMed:29191835). EIF6 phosphorylation promotes its nuclear export. Triggers down-regulation of dopamine receptors in the forebrain. Activates DCK in vitro by phosphorylation. TOP2A phosphorylation favors DNA cleavable complex formation. May regulate the formation of the mitotic spindle apparatus in extravillous trophoblast. Modulates connexin-43/GJA1 gap junction assembly by phosphorylation. Probably involved in lymphocyte physiology. Regulates fast synaptic transmission mediated by glutamate. {ECO:0000269|PubMed:10848614, ECO:0000269|PubMed:16014721, ECO:0000269|PubMed:17101137, ECO:0000269|PubMed:19414593, ECO:0000269|PubMed:19948962, ECO:0000269|PubMed:20145109, ECO:0000269|PubMed:20192920, ECO:0000269|PubMed:20421981, ECO:0000269|PubMed:21930935, ECO:0000269|PubMed:29191835}.
uniprot
proteins
mass_dalton
47316
uniprot
proteins
mutagenesis
MUTAGEN 38; /note="K->M: Abolishes NEDD9 phosphorylation."; /evidence="ECO:0000269|PubMed:29191835"; MUTAGEN 44; /note="T->A: Increases pain sensitivity; reduces threshold for induction of cortical spreading depression; increases arterial dilation during cortical spreading depression and increases spontaneous and evoked calcium signaling in astrocytes."; /evidence="ECO:0000269|PubMed:23636092
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated on serine and threonine residues; this autophosphorylation represses activity. Reactivated by phosphatase-mediated dephosphorylation. May be dephosphorylated by PP1.
uniprot
proteins
protein_family
CK1 Ser/Thr protein kinase family
uniprot
proteins
protein_family
Casein kinase I subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10848614
uniprot
proteins
pubmed
11779462
uniprot
proteins
pubmed
12924632
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16014721
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17101137
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19414593
uniprot
proteins
pubmed
19948962
uniprot
proteins
pubmed
20145109
uniprot
proteins
pubmed
20192920
uniprot
proteins
pubmed
20421981
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21930935
uniprot
proteins
pubmed
23636092
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
29191835
uniprot
proteins
sequence_length
415
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:10848614, ECO:0000269|PubMed:17101137, ECO:0000269|PubMed:19414593}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Localized at mitotic spindle microtubules, and at the centrosomes and interphase in interphase cells. Recruited to the spindle apparatus and the centrosomes in response to DNA-damage. Correct subcellular localization requires kinase activity (By similarity). {ECO:0000250}.
uniprot
proteins