Lcat
entrez
24530
canonical
uniprot
P18424
canonical
ensembl
ENSRNOG00000019573
resolver
ensembl
ENSRNOG00055003235
resolver
ensp
ENSRNOP00000026583
resolver
ensp
ENSRNOP00000100686
resolver
ensp
ENSRNOP00055003725
resolver
enst
ENSRNOT00000026585
resolver
enst
ENSRNOT00000163120
resolver
enst
ENSRNOT00055005021
resolver
genesymbol
Lcat
resolver
uniprot
A0ABK0LBW5
resolver
uniprot
O35849
resolver
uniprot_entry
A0ABK0LBW5_RAT
resolver
uniprot_entry
LCAT_RAT
resolver
uniprot_sec
O35849
resolver
amino_acid_sequence
MGLPGSPWQWVLLLLGLLLPPATSFWLLNVLFPPHTTPKAELSNHTRPVILVPGCMGNRLEAKLDKPNVVNWLCYRKTEDFFTIWLDFNMFLPLGVDCWIDNTRVVYNRSSGHMSNAPGVQIRVPGFGKTYSVEYLDDNKLAGYLHTLVQNLVNNGYVRDETVRAAPYDWRLAPRQQDEYYQKLAGLVEEMYAAYGKPVFLIGHSLGCLHVLHFLLRQPQSWKDHFIDGFISLGAPWGGSIKPMRILASGDNQGIPIMSNIKLREEQRITTTSPWMFPAHHVWPEDHVFISTPNFNYTGQDFERFFADLHFEEGWHMFLQSRDLLAGLPAPGVEVYCLYGVGMPTAHTYIYDHNFPYKDPVAALYEDGDDTVATRSTELCGQWQGRQSQAVHLLPMNGTDHLNMVFSNKTLEHINAILLGAYRHGTPKSPTASLGPPTKE
uniprot
proteins
ec_number
2.3.1.43
uniprot
proteins
ec_number
3.1.1.47
uniprot
proteins
function
FUNCTION: Central enzyme in the extracellular metabolism of plasma lipoproteins. Synthesized mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1, plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms (By similarity). Has a preference for plasma 16:0-18:2 or 18:O-18:2 phosphatidylcholines (PubMed:14636062, PubMed:8820107). Catalyzes the hydrolysis of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor or PAF) to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso-PAF) (By similarity). Also catalyzes the transfer of the acetate group from PAF to 1-hexadecanoyl-sn-glycero-3-phosphocholine forming lyso-PAF (By similarity). Catalyzes the esterification of (24S)-hydroxycholesterol (24(S)OH-C), also known as cerebrosterol to produce 24(S)OH-C monoesters (By similarity). {ECO:0000250|UniProtKB:P04180, ECO:0000269|PubMed:14636062, ECO:0000269|PubMed:8820107}.
uniprot
proteins
mass_dalton
49882
uniprot
proteins
mutagenesis
MUTAGEN 173; /note="A->E: Reduced activity with 20-carbon phosphatidylcholine as substrate. Little change with 18-carbon phosphatidylcholine as substrate."; /evidence="ECO:0000269|PubMed:14636062
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
protein_family
Lipase family
uniprot
proteins
pubmed
14636062
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2402469
uniprot
proteins
pubmed
8820107
uniprot
proteins
pubmed
9219904
uniprot
proteins
sequence_length
440
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:14636062, ECO:0000269|PubMed:8820107, ECO:0000269|PubMed:9219904}. Note=Secreted into blood plasma (PubMed:8820107). Produced in astrocytes and secreted into cerebral spinal fluid (CSF) (By similarity). {ECO:0000250|UniProtKB:P04180, ECO:0000269|PubMed:8820107}.
uniprot
proteins