Amotl2
entrez
56332
canonical
uniprot
Q8K371
canonical
ensembl
ENSMUSG00000032531
resolver
ensp
ENSMUSP00000035121
resolver
ensp
ENSMUSP00000317122
resolver
enst
ENSMUST00000035121
resolver
genesymbol
Amotl2
resolver
uniprot
B8JK80
resolver
uniprot
Q3TPM1
resolver
uniprot
Q7TPE4
resolver
uniprot
Q8BP84
resolver
uniprot
Q8BS08
resolver
uniprot
Q9QUS0
resolver
uniprot_entry
AMOL2_MOUSE
resolver
uniprot_sec
B8JK80
resolver
uniprot_sec
Q3TPM1
resolver
uniprot_sec
Q7TPE4
resolver
uniprot_sec
Q8BP84
resolver
uniprot_sec
Q8BS08
resolver
uniprot_sec
Q9QUS0
resolver
amino_acid_sequence
MRTLEDSSGTVLHRLIQEQLRYGNLTETRTLLAIQQQALRGGAGAGGTGSPQASLEIGAPEDSQVLQQATRQEPQGQEHQGGETHLAENRLYRLCPQPSKGEELPTYEEAKAHSQYYAAQQAGSRPHVGDRDPRGGVSGGGRRQDEALRELRHGHVRSLSERLLQLSLERNGARVPSHMSSSHSFPQLARSQQGPQPRGPPAEGPEPRGPPPQYPHAVMAQETAAVTDPRYRPRSSPHFQHAEVRILQAQVPPVFLQQQQYQYLPQPQEHSPPLHPAALGHGPPSSFGPPAVEGPPSAQATLGSAHLAQMETVLRENARLQRDNERLQRELESTSEKAGRIEKLENEIQRLSEAHESLMRTSSKREALEKTMRNKMDGEMRRLQDFNRDLRERLESANRHLASKTQEAQAGSQDMVAKLLAQSYEQQQEQEKLEREMALLRGAIEDQRRHAELLEQALGNAQSRAARAEEELRKKQAYVEKVERLQQALGQLQAACEKREQLELRLRTRLEQELKALRAQQRQTGTLAGGGGSHGGSAELSALRLSEQLREKEEQILALEADMTKWEQKYLEERAMRQFAMDAAATAAAQRDTTLIRHSPQPSPSSSFNEGLLPGNHRHQEMESRLKVLHAQILEKDAVIKVLQQRSRKDPGKATQGTLRPAKSVPSIFAAAVGTQGWQGLVSSERQTDARPAGDRVPAEEPPATAPLPAHTKHGSRDGSTQTDGPADNTSACLASEPDGLLGCNSSQRTPSLDSIAATRVQDLSDMVEILI
uniprot
proteins
function
FUNCTION: Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Plays a role in coupling actin fibers to cell junctions in endothelial cells and is therefore required for correct endothelial cell morphology via facilitating transcellular transmission of mechanical force resulting in endothelial cell elongation (PubMed:24806444). Required for the anchoring of radial actin fibers to CDH1 junction complexes at the cell membrane which facilitates organization of radial actin fiber structure and cellular response to contractile forces (PubMed:28842668). This contributes to maintenance of cell area, size, shape, epithelial sheet organization and trophectoderm cell properties that facilitate blastocyst zona hatching (PubMed:28842668). Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. Activates the Hippo signaling pathway in response to cell contact inhibition via interaction with and ubiquitination by Crumbs complex-bound WWP1 (By similarity). Ubiquitinated AMOTL2 then interacts with LATS2 which in turn phosphorylates YAP1, excluding it from the nucleus and localizing it to the cytoplasm and tight junctions, therefore ultimately repressing YAP1-driven transcription of target genes (By similarity). Acts to inhibit WWTR1/TAZ transcriptional coactivator activity via sequestering WWTR1/TAZ in the cytoplasm and at tight junctions (By similarity). Regulates the size and protein composition of the podosome cortex and core at myofibril neuromuscular junctions (PubMed:23525008). Selectively promotes FGF-induced MAPK activation through SRC (By similarity). May play a role in the polarity, proliferation and migration of endothelial cells. {ECO:0000250, ECO:0000250|UniProtKB:Q9Y2J4, ECO:0000269|PubMed:23525008, ECO:0000269|PubMed:24806444, ECO:0000269|PubMed:28842668}.
uniprot
proteins
mass_dalton
85278
uniprot
proteins
mutagenesis
MUTAGEN 107; /note="Y->A: Abolishes interaction with MAGI1 and ACTB. No effect on interaction with CDH5."; /evidence="ECO:0000269|PubMed:24806444"; MUTAGEN 214; /note="Y->A: No effect on interaction with CDH5, MAGI1 and ACTB."; /evidence="ECO:0000269|PubMed:24806444
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Tyr-107 is necessary for efficient binding to SRC and synergistically functioning with SRC to activate the downstream MAPK pathway. {ECO:0000250|UniProtKB:A1YB07}.; PTM: Monoubiquitinated at Lys-343 and Lys-404 by Crumbs complex-bound WWP1 (By similarity). De-ubiquitinated at Lys-343 and Lys-404 by USP9X; the interaction may be promoted by cell contact inhibition (By similarity). Deubiquitination of AMOTL2 negatively regulates Hippo signaling activation (By similarity). {ECO:0000250|UniProtKB:Q9Y2J4}.
uniprot
proteins
protein_family
Angiomotin family
uniprot
proteins
pubmed
12406577
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21205866
uniprot
proteins
pubmed
23525008
uniprot
proteins
pubmed
24806444
uniprot
proteins
pubmed
28842668
uniprot
proteins
sequence_length
772
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Recycling endosome {ECO:0000250|UniProtKB:A1YB07}. Cytoplasm {ECO:0000269|PubMed:24806444}. Cell projection, podosome {ECO:0000269|PubMed:23525008}. Cell junction {ECO:0000269|PubMed:24806444, ECO:0000269|PubMed:28842668}.
uniprot
proteins