SPATA13
entrez
221178
canonical
uniprot
Q96N96
canonical
ensembl
ENSG00000182957
resolver
ensp
ENSP00000343631
resolver
ensp
ENSP00000371527
resolver
ensp
ENSP00000371542
resolver
ensp
ENSP00000382830
resolver
ensp
ENSP00000386471
resolver
enst
ENST00000409126
resolver
genesymbol
SPATA13
resolver
hgnc
HGNC:23222
resolver
uniprot
A2VEA9
resolver
uniprot
A6NF85
resolver
uniprot
B4DMC2
resolver
uniprot
B4DQB1
resolver
uniprot
B4DSZ0
resolver
uniprot
B4DVM8
resolver
uniprot
E9PFR9
resolver
uniprot
J3KPJ7
resolver
uniprot
J3KQH2
resolver
uniprot
Q5VX68
resolver
uniprot
Q6ZML1
resolver
uniprot
Q8N873
resolver
uniprot
Q8TEK6
resolver
uniprot_entry
B4DMC2_HUMAN
resolver
uniprot_entry
E9PFR9_HUMAN
resolver
uniprot_entry
SPT13_HUMAN
resolver
uniprot_sec
A2VEA9
resolver
uniprot_sec
A6NF85
resolver
uniprot_sec
B4DQB1
resolver
uniprot_sec
B4DSZ0
resolver
uniprot_sec
B4DVM8
resolver
uniprot_sec
J3KPJ7
resolver
uniprot_sec
J3KQH2
resolver
uniprot_sec
Q5VX68
resolver
uniprot_sec
Q6ZML1
resolver
uniprot_sec
Q8N873
resolver
uniprot_sec
Q8TEK6
resolver
activity_regulation
ACTIVITY REGULATION: Both the ABR and the SH3 domains contribute to maintaining the protein in an inhibited conformation by associating with the C-terminal tail. Binding of these domains to the C-terminal tail inhibits the activity of the protein by blocking a region that is required for its GEF activity. {ECO:0000269|PubMed:17145773}.
uniprot
proteins
amino_acid_sequence
MTSASPEDQNAPVGCPKGARRRRPISVIGGVSLYGTNQTEELDNLLTQPASRPPMPAHQVPPYKAVSARFRPFTFSQSTPIGLDRVGRRRQMRASNVSSDGGTEPSALVDDNGSEEDFSYEDLCQASPRYLQPGGEQLAINELISDGNVVCAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWFPASFVRLRVNQEELSENSSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYNKEEPHLSEIGSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQGKYRHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIARWQVSIVGWEGLDILDRSSELIHSGELTKITKQGKSQQRTFFLFDHQLVSCKKDLLRRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYLFCAKKQEDKARWLQACADERRRVQEDKEMGMEISENQKKLAMLNAQKAGHGKSKGYNRCPVAPPHQGLHPIHQRHITMPTSVPQQQVFGLAEPKRKSSLFWHTFNRLTPFRK
uniprot
proteins
function
FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. {ECO:0000269|PubMed:17145773, ECO:0000269|PubMed:17599059, ECO:0000269|PubMed:19151759, ECO:0000269|PubMed:19893577, ECO:0000269|PubMed:19934221}.
uniprot
proteins
mass_dalton
74820
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17145773
uniprot
proteins
pubmed
17599059
uniprot
proteins
pubmed
19151759
uniprot
proteins
pubmed
19893577
uniprot
proteins
pubmed
19934221
uniprot
proteins
pubmed
28397838
uniprot
proteins
sequence_length
652
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cell projection, filopodium. Cell projection, lamellipodium. Cell projection, ruffle membrane. Cell projection, podosome {ECO:0000250|UniProtKB:Q5DU57}. Note=Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. Localized to the core of myotube podosomes (By similarity). {ECO:0000250|UniProtKB:Q5DU57}.
uniprot
proteins