Sec61a2
entrez
57743
canonical
uniprot
Q9JLR1
canonical
ensembl
ENSMUSG00000025816
resolver
ensp
ENSMUSP00000100046
resolver
ensp
ENSMUSP00000141333
resolver
ensp
ENSMUSP00000176683
resolver
ensp
ENSMUSP00000176686
resolver
ensp
ENSMUSP00000176704
resolver
ensp
ENSMUSP00000357244
resolver
enst
ENSMUST00000102981
resolver
enst
ENSMUST00000193792
resolver
genesymbol
Sec61a2
resolver
uniprot
A0A0A6YVZ9
resolver
uniprot
Q9CYJ6
resolver
uniprot_entry
A0A0A6YVZ9_MOUSE
resolver
uniprot_entry
Q9CYJ6_MOUSE
resolver
uniprot_entry
S61A2_MOUSE
resolver
amino_acid_sequence
MGIKFLEVIKPFCAVLPEIQKPERKIQFREKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMIITIGQAIVYVMTGMYGDPAEMGAGICLLIIIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTINTGRGTEFEGAVIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATVFVFAVVIYFQGFRVDLPIKSARYRGQYSSYPIKLFYTSNIPIILQSALVSNLYVISQMLSVRFSGNFLVNLLGQWADVSGGGPARSYPVGGLCYYLSPPESMGAIFEDPVHVVVYIIFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRDTSMVHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQAEVGGMGALFF
uniprot
proteins
function
FUNCTION: Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. {ECO:0000250|UniProtKB:P61619}.
uniprot
proteins
mass_dalton
52248
uniprot
proteins
protein_family
SecY/SEC61-alpha family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
476
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P61619}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..53; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 77..96; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 118..138; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 145..165; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 173..193; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 241..261; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 289..309; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 355..375; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 421..441; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 446..462; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins