Klrk1
entrez
27007
canonical
uniprot
O54709
canonical
ensembl
ENSMUSG00000030149
resolver
ensp
ENSMUSP00000032252
resolver
ensp
ENSMUSP00000093061
resolver
ensp
ENSMUSP00000130398
resolver
ensp
ENSMUSP00000351964
resolver
enst
ENSMUST00000168919
resolver
genesymbol
Klrk1
resolver
genesymbol_syn
Nkg2d
resolver
uniprot
F6RGL4
resolver
uniprot
Q3TCW7
resolver
uniprot
Q4FJM0
resolver
uniprot_entry
F6RGL4_MOUSE
resolver
uniprot_entry
NKG2D_MOUSE
resolver
uniprot_entry
Q3TCW7_MOUSE
resolver
uniprot_entry
Q4FJM0_MOUSE
resolver
amino_acid_sequence
MALIRDRKSHHSEMSKCHNYDLKPAKWDTSQEQQKQRLALTTSQPGENGIIRGRYPIEKLKISPMFVVRVLAIALAIRFTLNTLMWLAIFKETFQPVLCNKEVPVSSREGYCGPCPNNWICHRNNCYQFFNEEKTWNQSQASCLSQNSSLLKIYSKEEQDFLKLVKSYHWMGLVQIPANGSWQWEDGSSLSYNQLTLVEIPKGSCAVYGSSFKAYTEDCANLNTYICMKRAV
uniprot
proteins
disease_involvement
DISEASE: Note=Involved in autoreactive CD8(+) T-cell-mediated development of autoimmune diabetes. {ECO:0000269|PubMed:15189740}.
uniprot
proteins
function
FUNCTION: Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including RAET1A, RAET1B, RAET1C, RAET1D, RAET1E, H60 and MULT1. {ECO:0000269|PubMed:10894171, ECO:0000269|PubMed:11248803, ECO:0000269|PubMed:11557981, ECO:0000269|PubMed:11567106, ECO:0000269|PubMed:12150888, ECO:0000269|PubMed:12370332, ECO:0000269|PubMed:12426564, ECO:0000269|PubMed:12426565, ECO:0000269|PubMed:15189740, ECO:0000269|PubMed:16086018, ECO:0000269|PubMed:18394936, ECO:0000269|PubMed:19631564, ECO:0000269|PubMed:21898152, ECO:0000269|PubMed:23298206}.
uniprot
proteins
mass_dalton
26710
uniprot
proteins
pubmed
10894171
uniprot
proteins
pubmed
11224525
uniprot
proteins
pubmed
11248803
uniprot
proteins
pubmed
11557981
uniprot
proteins
pubmed
11567106
uniprot
proteins
pubmed
11825567
uniprot
proteins
pubmed
11973127
uniprot
proteins
pubmed
12150888
uniprot
proteins
pubmed
12370332
uniprot
proteins
pubmed
12426564
uniprot
proteins
pubmed
12426565
uniprot
proteins
pubmed
15048723
uniprot
proteins
pubmed
15189740
uniprot
proteins
pubmed
15294961
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16086018
uniprot
proteins
pubmed
18394936
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19631564
uniprot
proteins
pubmed
21898152
uniprot
proteins
pubmed
23298206
uniprot
proteins
pubmed
9464811
uniprot
proteins
pubmed
9600963
uniprot
proteins
sequence_length
232
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12426565, ECO:0000269|PubMed:15294961}; Single-pass type II membrane protein {ECO:0000269|PubMed:12426565, ECO:0000269|PubMed:15294961}. Note=Colocalized with HCST and TYROBP on the cell surface.
uniprot
proteins
transmembrane_region
TRANSMEM 67..89; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins