Psma3
entrez
19167
canonical
uniprot
O70435
canonical
ensembl
ENSMUSG00000060073
resolver
ensp
ENSMUSP00000124894
resolver
ensp
ENSMUSP00000125548
resolver
ensp
ENSMUSP00000318232
resolver
enst
ENSMUST00000160027
resolver
enst
ENSMUST00000160864
resolver
genesymbol
Psma3
resolver
uniprot
E0CX62
resolver
uniprot
Q3TEL1
resolver
uniprot
Q58EV4
resolver
uniprot_entry
E0CX62_MOUSE
resolver
uniprot_entry
PSA3_MOUSE
resolver
uniprot_entry
Q3TEL1_MOUSE
resolver
uniprot_entry
Q58EV4_MOUSE
resolver
amino_acid_sequence
MSSIGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYSAVRPFGCSFMLGSYSANDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTCRDVVKEVAKIIYIVHDEVKDKAFELELSWVGELTKGRHEIVPKDIREEAEKYAKESLKEEDESDDDNM
uniprot
proteins
function
FUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Binds to the C-terminus of CDKN1A and thereby mediates its degradation. Negatively regulates the membrane trafficking of the cell-surface thromboxane A2 receptor (TBXA2R) isoform 2. {ECO:0000269|PubMed:16581775, ECO:0000269|PubMed:22341445}.
uniprot
proteins
mass_dalton
28405
uniprot
proteins
protein_family
Peptidase T1A family
uniprot
proteins
pubmed
10436176
uniprot
proteins
pubmed
16581775
uniprot
proteins
pubmed
16857966
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22341445
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
255
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P25788}. Nucleus {ECO:0000250|UniProtKB:P25788}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9. {ECO:0000250|UniProtKB:P25788}.
uniprot
proteins