Sh3pxd2b
entrez
268396
canonical
uniprot
A2AAY5
canonical
ensembl
ENSMUSG00000040711
resolver
ensp
ENSMUSP00000044276
resolver
ensp
ENSMUSP00000158896
resolver
enst
ENSMUST00000038753
resolver
enst
ENSMUST00000239041
resolver
genesymbol
Sh3pxd2b
resolver
genesymbol_syn
Fad49
resolver
genesymbol_syn
Tks4
resolver
uniprot
A0A5F8MPP7
resolver
uniprot
B6F0V1
resolver
uniprot
Q1LZL8
resolver
uniprot
Q1LZM5
resolver
uniprot
Q3TB89
resolver
uniprot
Q8BIC6
resolver
uniprot_entry
A0A5F8MPP7_MOUSE
resolver
uniprot_entry
SPD2B_MOUSE
resolver
uniprot_sec
B6F0V1
resolver
uniprot_sec
Q1LZL8
resolver
uniprot_sec
Q1LZM5
resolver
uniprot_sec
Q3TB89
resolver
uniprot_sec
Q8BIC6
resolver
amino_acid_sequence
MPPRRSIVEVKVLDVQKRRVPNKHYVYIIRVTWSSGATEAIYRRYSKFFDLQMQMLDKFPMEGGQKDPKQRIIPFLPGKILFRRSHIRDVAVKRLIPIDEYCKALIQLPPYISQCDEVLQFFETRPEDLNPPKEEHIGKKKSGNDPTSVDPMVLEQYVVVADYQKQESSEISLSVGQVVDIIEKNESGWWFVSTAEEQGWVPATCLEGQDGVQDEFSLQPEEEEKYTVIYPYTARDQDEMNLERGAVVEVVQKNLEGWWKIRYQGKEGWAPASYLKKNSGEPLPPKLGPSSPAHSGALDLDGVSRHQNAMGREKELLNNQRDGRFEGRLVPDGDVKQRSPKMRQRPPPRRDMTIPRGLNLPKPPIPPQVEEEYYTIAEFQTTIPDGISFQAGLKVEVIEKSLSGWWYIQMEDKEGWAPATFIDKYKKTSSASRPNFLAPLPHEMTQLRLGDAAATENNTGPEAVGPSRPLPEAPHGAVDSGMLWSKDWKGGKEAPRKASSDLSASTGYEEISDPTQEEKPSLPPRKESIIKSEEELLERERQKMEPLRGSSPKPPGMILPMIPAKHAPLARDSRKPEPKLDKSKFPLRNDMGLECGHKVLAKEVKKPNLRPISRSKAELSEEKVDPTSQNLFMKSRPQVRPKPTPSPKTEPAQSEDHVDIYNLRSKLRPAKSQEKALLDGESHHAAGSHDTALSRSFLPGEGPGHGQDRSGRQDGLSPKETPCRAPPRPAKTTDPGPKNVPVPVQEATLQQRPVVPPRRPPPPKKTSSSPLSCRPLPEVRGAQREESRVAPAAGRALLVPPKAKPFLSNSSVGQDDMRGKGGLGPRVTGKVGETREKAASFLNADGPKDSLYVAVANFEGDEDTSSFQEGTVFEVREKNSSGWWFCQVLSGAPSWEGWIPSNYLRKKP
uniprot
proteins
function
FUNCTION: Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation. {ECO:0000269|PubMed:18959745, ECO:0000269|PubMed:19144821, ECO:0000269|PubMed:19755710}.
uniprot
proteins
mass_dalton
101517
uniprot
proteins
mutagenesis
MUTAGEN 25; /note="Y->F: Reduced phosphorylation. Almost complete loss of phosphorylation; when associated with F-373 and F-508."; /evidence="ECO:0000269|PubMed:19144821"; MUTAGEN 373; /note="Y->F: Reduced phosphorylation. Almost complete loss of phosphorylation; when associated with F-25 and F-508."; /evidence="ECO:0000269|PubMed:19144821"; MUTAGEN 508; /note="Y->F: Reduced phosphorylation. Almost complete loss of phosphorylation; when associated with F-25 and F-373."; /evidence="ECO:0000269|PubMed:19144821
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in SRC-transformed cells. {ECO:0000269|PubMed:19144821}.
uniprot
proteins
protein_family
SH3PXD2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18959745
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19144821
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19669234
uniprot
proteins
pubmed
19755710
uniprot
proteins
pubmed
20137777
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
908
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cell projection, podosome. Note=Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells.
uniprot
proteins