Neu1
entrez
18010
canonical
uniprot
O35657
canonical
ensembl
ENSMUSG00000007038
resolver
ensp
ENSMUSP00000007253
resolver
enst
ENSMUST00000007253
resolver
genesymbol
Neu1
resolver
genesymbol_syn
Neu
resolver
uniprot
O55220
resolver
uniprot
Q3UL64
resolver
uniprot
Q99KG9
resolver
uniprot_entry
NEUR1_MOUSE
resolver
uniprot_entry
Q3UL64_MOUSE
resolver
uniprot_sec
O55220
resolver
uniprot_sec
Q99KG9
resolver
amino_acid_sequence
MVGADPTRPRGPLSYWAGRRGQGLAAIFLLLVSAAESEARAEDDFSLVQPLVTMEQLLWVSGKQIGSVDTFRIPLITATPRGTLLAFAEARKKSASDEGAKFIAMRRSTDQGSTWSSTAFIVDDGEASDGLNLGAVVNDVDTGIVFLIYTLCAHKVNCQVASTMLVWSKDDGISWSPPRNLSVDIGTEMFAPGPGSGIQKQREPGKGRLIVCGHGTLERDGVFCLLSDDHGASWHYGTGVSGIPFGQPKHDHDFNPDECQPYELPDGSVIINARNQNNYHCRCRIVLRSYDACDTLRPRDVTFDPELVDPVVAAGALATSSGIVFFSNPAHPEFRVNLTLRWSFSNGTSWQKERVQVWPGPSGYSSLTALENSTDGKKQPPQLFVLYEKGLNRYTESISMVKISVYGTL
uniprot
proteins
ec_number
3.2.1.18
uniprot
proteins
function
FUNCTION: Lysosomal exo-alpha-sialidase that catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins and glycolipids. To be active, it is strictly dependent on its presence in the multienzyme complex. Appears to have a preference for alpha 2-3 and alpha 2-6 sialyl linkage. {ECO:0000269|PubMed:37205763, ECO:0000269|PubMed:9363440, ECO:0000269|PubMed:9384611}.
uniprot
proteins
mass_dalton
44591
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q99519}.; PTM: Phosphorylation of tyrosine within the internalization signal results in inhibition of sialidase internalization and blockage on the plasma membrane. {ECO:0000250|UniProtKB:Q99519}.
uniprot
proteins
protein_family
Glycosyl hydrolase 33 family
uniprot
proteins
pubmed
14656967
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
37205763
uniprot
proteins
pubmed
9363440
uniprot
proteins
pubmed
9384611
uniprot
proteins
pubmed
9425240
uniprot
proteins
sequence_length
409
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome lumen {ECO:0000269|PubMed:9384611}. Lysosome membrane {ECO:0000269|PubMed:9384611}; Peripheral membrane protein {ECO:0000305|PubMed:9384611}; Lumenal side {ECO:0000305|PubMed:9384611}. Cell membrane {ECO:0000269|PubMed:9384611}; Peripheral membrane protein {ECO:0000305|PubMed:9384611}. Note=Localized not only on the inner side of the lysosomal membrane and in the lysosomal lumen, but also on the plasma membrane and in intracellular vesicles. Was also suggested to have transmembrane topology. {ECO:0000250|UniProtKB:Q99519}.
uniprot
proteins