NFKBIB
entrez
4793
canonical
uniprot
Q15653
canonical
ensembl
ENSG00000104825
resolver
ensembl
ENSG00000282905
resolver
ensp
ENSP00000312988
resolver
ensp
ENSP00000375929
resolver
ensp
ENSP00000459728
resolver
ensp
ENSP00000489191
resolver
ensp
ENSP00000618683
resolver
enst
ENST00000392079
resolver
enst
ENST00000634995
resolver
genesymbol
NFKBIB
resolver
genesymbol_syn
IKBB
resolver
genesymbol_syn
TRIP9
resolver
hgnc
HGNC:7798
resolver
uniprot
A8K3F4
resolver
uniprot
G5E9C2
resolver
uniprot
Q96BJ7
resolver
uniprot_entry
G5E9C2_HUMAN
resolver
uniprot_entry
IKBB_HUMAN
resolver
uniprot_sec
A8K3F4
resolver
uniprot_sec
Q96BJ7
resolver
amino_acid_sequence
MAGVACLGKAADADEWCDSGLGSLGPDAAAPGGPGLGAELGPGLSWAPLVFGYVTEDGDTALHLAVIHQHEPFLDFLLGFSAGTEYMDLQNDLGQTALHLAAILGETSTVEKLYAAGAGLCVAERRGHTALHLACRVGAHACARALLQPRPRRPREAPDTYLAQGPDRTPDTNHTPVALYPDSDLEKEEEESEEDWKLQLEAENYEGHTPLHVAVIHKDVEMVRLLRDAGADLDKPEPTCGRSPLHLAVEAQAADVLELLLRAGANPAARMYGGRTPLGSAMLRPNPILARLLRAHGAPEPEGEDEKSGPCSSSSDSDSGDEGDEYDDIVVHSSRSQTRLPPTPASKPLPDDPRPV
uniprot
proteins
function
FUNCTION: Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation.
uniprot
proteins
mass_dalton
37771
uniprot
proteins
mutagenesis
MUTAGEN 19; /note="S->A: No degradation; when associated with A-23."; /evidence="ECO:0000269|PubMed:8657102"; MUTAGEN 23; /note="S->A: No degradation; when associated with A-19."; /evidence="ECO:0000269|PubMed:8657102
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by RPS6KA1; followed by degradation. Interaction with NKIRAS1 and NKIRAS2 probably prevents phosphorylation. {ECO:0000269|PubMed:8657102, ECO:0000269|PubMed:8887627}.
uniprot
proteins
protein_family
NF-kappa-B inhibitor family
uniprot
proteins
pubmed
10657303
uniprot
proteins
pubmed
12672800
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15024091
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16573520
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
7776974
uniprot
proteins
pubmed
8657102
uniprot
proteins
pubmed
8816457
uniprot
proteins
pubmed
8887627
uniprot
proteins
sequence_length
356
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
uniprot
proteins