Rp2
entrez
19889
canonical
uniprot
Q9EPK2
canonical
ensembl
ENSMUSG00000060090
resolver
ensp
ENSMUSP00000033372
resolver
ensp
ENSMUSP00000111045
resolver
ensp
ENSMUSP00000111049
resolver
genesymbol
Rp2
resolver
genesymbol_syn
Rp2h
resolver
uniprot
Q8BLN8
resolver
uniprot
Q8BVQ8
resolver
uniprot
Q8BZP9
resolver
uniprot_entry
XRP2_MOUSE
resolver
uniprot_sec
Q8BLN8
resolver
uniprot_sec
Q8BVQ8
resolver
uniprot_sec
Q8BZP9
resolver
amino_acid_sequence
MGCCFTKRRKSEKAEGEEEQPKLYSWDQREKVDPKDYMFSGLKDETVGRLPGKVAGQQFVIQDCENCNIYIFDHSATITIDDCTNCVIFLGPVKGSVFFRNCRDCKCTLACQQFRVRDCRKLEVFLCCATQPIIESSTNIKFGCFQWYYPELAAQFKDAGLSIFNNIWSHVHDFTPVSGELNWSLLPENAVVQDYVPIPMTEEFKAVRISTEANRSIVPVSRGQRQKYSDESCLVVLFADDYTTANARKLIDEMVGKGFSLVQTKEMSMKTEDAQRVFQEKASDFLLLLNKGPVIALEFNGDDAVQECHLIVNGMFNGTKMFVSEKKETASGDVDSFYNFAEIQMGI
uniprot
proteins
function
FUNCTION: Acts as a GTPase-activating protein (GAP) involved in trafficking between the Golgi and the ciliary membrane. Involved in localization of proteins, such as NPHP3, to the cilium membrane by inducing hydrolysis of GTP ARL3, leading to the release of UNC119 (or UNC119B). Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization. Acts as a guanine nucleotide dissociation inhibitor towards ADP-ribosylation factor-like proteins.
uniprot
proteins
mass_dalton
39377
uniprot
proteins
post_translational_modification
PTM: Myristoylated on Gly-2; which may be required for membrane targeting. {ECO:0000305}.; PTM: Palmitoylated on Cys-3; which may be required for plasma membrane targeting. {ECO:0000305}.
uniprot
proteins
protein_family
TBCC family
uniprot
proteins
pubmed
11371510
uniprot
proteins
pubmed
12417528
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
347
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O75695}; Lipid-anchor {ECO:0000250|UniProtKB:O75695}; Cytoplasmic side {ECO:0000250|UniProtKB:O75695}. Cell projection, cilium {ECO:0000250|UniProtKB:O75695}. Note=Detected predominantly at the plasma membrane of rod and cone photoreceptors. Not detected in the nucleus. {ECO:0000250|UniProtKB:O75695}.
uniprot
proteins