Pdk2
entrez
81530
canonical
uniprot
Q64536
canonical
ensembl
ENSRNOG00000004172
resolver
ensp
ENSRNOP00000093282
resolver
enst
ENSRNOT00000102681
resolver
genesymbol
Pdk2
resolver
uniprot
A0A8I6AJH2
resolver
uniprot
Q9JID3
resolver
uniprot_entry
A0A8I6AJH2_RAT
resolver
uniprot_entry
PDK2_RAT
resolver
uniprot_entry
Q9JID3_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activity increases in response to increased acetyl-CoA and NADH levels and upon binding to the pyruvate dehydrogenase subunit DLAT. Inhibited by ADP and pyruvate; these compounds interfere with DLAT binding and thereby inhibit kinase activity. Inhibited by dichloroacetate. Inhibited by AZD7545; this compound interferes with DLAT binding and thereby inhibits kinase activity. Reactive oxygen species cause the formation of disulfide bonds, and thereby inhibit the enzyme. {ECO:0000269|PubMed:22910903, ECO:0000269|PubMed:9405293}.
uniprot
proteins
amino_acid_sequence
MRWFRALLKNASLAGAPKYIEHFSKFSPSPLSMKQFLDFGSSNACEKTSFTFLRQELPVRLANIMKEINLLPDRVLSTPSVQLVQSWYVQSLLDIMEFLDKDPEDHRTLSQFTDALVTIRNRHNDVVPTMAQGVLEYKDTYGDDPVSNQNIQYFLDRFYLSRISIRMLINQHTLIFDGSTNPAHPKHIGSIDPNCSVSDVVKDAYDMAKLLCDKYYMASPDLEIQEVNATNATQPIHMVYVPSHLYHMLFELFKNAMRATVESHESSLTLPPIKIMVALGEEDLSIKMSDRGGGVPLRKIERLFSYMYSTAPTPQPGTGGTPLAGFGYGLPISRLYAKYFQGDLQLFSMEGFGTDAVIYLKALSTDSVERLPVYNKSAWRHYQTIQEAGDWCVPSTEPKNTSTYRVS
uniprot
proteins
ec_number
2.7.11.2
uniprot
proteins
function
FUNCTION: Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis. {ECO:0000269|PubMed:11486000, ECO:0000269|PubMed:12573248, ECO:0000269|PubMed:14641018, ECO:0000269|PubMed:22910903, ECO:0000269|PubMed:7961963}.
uniprot
proteins
mass_dalton
46106
uniprot
proteins
protein_family
PDK/BCKDK protein kinase family
uniprot
proteins
pubmed
11483605
uniprot
proteins
pubmed
11486000
uniprot
proteins
pubmed
11978179
uniprot
proteins
pubmed
12573248
uniprot
proteins
pubmed
14641018
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18387944
uniprot
proteins
pubmed
22910903
uniprot
proteins
pubmed
7961963
uniprot
proteins
pubmed
9405293
uniprot
proteins
sequence_length
407
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:22910903}.
uniprot
proteins