St6galnac1
entrez
20445
canonical
uniprot
Q9QZ39
canonical
ensembl
ENSMUSG00000009588
resolver
ensp
ENSMUSP00000009732
resolver
enst
ENSMUST00000009732
resolver
genesymbol
St6galnac1
resolver
genesymbol_syn
Siat7a
resolver
uniprot
A2AA23
resolver
uniprot
Q9JJP5
resolver
uniprot_entry
SIA7A_MOUSE
resolver
uniprot_sec
A2AA23
resolver
uniprot_sec
Q9JJP5
resolver
amino_acid_sequence
MTRYCRGLSQRQAFLLLTVLALLFILLFVVKDPRAKDSRCQFIWKNDASAQENQQKAEPQVPIMTLSPRVHNKETTSVSSKDLKKQEREAVQGEQAEGKEKRKLETIRPAPENPQSKAEPAAKTPVSEHLDKLPRAPGALSTRKTPMATGAVPAKKKVVQATKSPASSPHPTTRRRQRLKASEFKSEPRWDFEEEYSLDMSSLQTNCSASVKIKASKSPWLQNIFLPNITLFLDSGRFTQSEWNRLEHFAPPFGFMELNQSLVQKVVTRFPPVRQQQLLLASLPTGYSKCITCAVVGNGGILNDSRVGREIDSHDYVFRLSGAVIKGYEQDVGTRTSFYGFTAFSLTQSILILGRRGFQHVPLGKDVRYLHFLEGTRDYEWLEAMFLNQTLAKTHLSWFRHRPQEAFRNALDLDRYLLLHPDFLRYMKNRFLRSKTLDTAHWRIYRPTTGALLLLTALHLCDKVSAYGFITEGHQRFSDHYYDTSWKRLIFYINHDFRLERMVWKRLHDEGIIWLYQRPQSDKAKN
uniprot
proteins
ec_number
2.4.3.3
uniprot
proteins
function
FUNCTION: Protein sialyltransferase specifically expressed in goblet cells that plays a key role in intestinal host-commensal homeostasis (PubMed:35303419). Conjugates sialic acid with an alpha-2-6 linkage to N-acetylgalactosamine (GalNAc) glycan chains linked to serine or threonine in glycoproteins (PubMed:10788794). Catalyzes the formation of the sialyl-Tn (S-Tn) antigen, an antigen found in intestinal goblet cells (PubMed:35303419, PubMed:16207894). Protein sialylation in globlet cells is essential for mucus integrity and is required to protect the intestinal mucus against excessive bacterial proteolytic degradation (PubMed:35303419). {ECO:0000269|PubMed:10788794, ECO:0000269|PubMed:35303419}.
uniprot
proteins
mass_dalton
60734
uniprot
proteins
mutagenesis
MUTAGEN 319; /note="R->Q: Knockin mice display compromised mucus barriers, dysbiosis with reduced bacterial diversity, as well as susceptibility to intestinal inflammation."; /evidence="ECO:0000269|PubMed:35303419
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000305|PubMed:10788794}.
uniprot
proteins
post_translational_modification
PTM: Glycosylated; autosialylated. {ECO:0000250|UniProtKB:Q9NSC7}.
uniprot
proteins
protein_family
Glycosyltransferase 29 family
uniprot
proteins
pubmed
10788794
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16207894
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
35303419
uniprot
proteins
sequence_length
526
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9NSC7}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9NSC7}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..33; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins