CLEC10A
entrez
10462
canonical
uniprot
Q8IUN9
canonical
ensembl
ENSG00000132514
resolver
ensp
ENSP00000254868
resolver
ensp
ENSP00000414938
resolver
ensp
ENSP00000460252
resolver
ensp
ENSP00000544131
resolver
ensp
ENSP00000544134
resolver
ensp
ENSP00000613540
resolver
ensp
ENSP00000613541
resolver
enst
ENST00000416562
resolver
enst
ENST00000874072
resolver
enst
ENST00000943481
resolver
genesymbol
CLEC10A
resolver
genesymbol_syn
CLECSF13
resolver
genesymbol_syn
CLECSF14
resolver
genesymbol_syn
HML
resolver
hgnc
HGNC:16916
resolver
uniprot
A8K8J8
resolver
uniprot
J3KR22
resolver
uniprot
Q14538
resolver
uniprot
Q6PIW3
resolver
uniprot_entry
CLC10_HUMAN
resolver
uniprot_entry
J3KR22_HUMAN
resolver
uniprot_sec
A8K8J8
resolver
uniprot_sec
Q14538
resolver
uniprot_sec
Q6PIW3
resolver
amino_acid_sequence
MTRTYENFQYLENKVKVQGFKNGPLPLQSLLQRLCSGPCHLLLSLGLGLLLLVIICVVGFQNSKFQRDLVTLRTDFSNFTSNTVAEIQALTSQGSSLEETIASLKAEVEGFKQERQAGVSELQEHTTQKAHLGHCPHCPSVCVPVHSEMLLRVQQLVQDLKKLTCQVATLNNNASTEGTCCPVNWVEHQDSCYWFSHSGMSWAEAEKYCQLKNAHLVVINSREEQNFVQKYLGSAYTWMGLSDPEGAWKWVDGTDYATGFQNWKPGQPDDWQGHGLGGGEDCAHFHPDGRWNDDVCQRPYHWVCEAGLGQTSQESH
uniprot
proteins
function
FUNCTION: C-type lectin receptor involved in recognition of N-acetylgalactosamine (GalNAc)-terminated glycans by myeloid antigen presenting cells (APCs) (PubMed:15802303, PubMed:16998493, PubMed:17616966, PubMed:22213806, PubMed:33724805, PubMed:8598452). Binds in a Ca(2+)-dependent manner to alpha- and beta-linked GalNAc residues on glycoprotein and glycolipid antigens, including alphaGalNAc- and Galbeta1->3GalNAc-O-Ser/Thr also known as Tn and T antigens, LacdiNAc epitope GalNAcbeta1->4GlcNAc and its derivative GalNAcbeta1->4-(Fucalpha1->3)GlcNAc, O-linked core 5 and 6 glycans, and GM2 and GD2 gangliosides (PubMed:15802303, PubMed:23507963). Acts as a signaling receptor at the interface of APC-T cell interactions. On immature dendritic cells, recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and down-regulates PTRPN/CD45 phosphatase activity with an impact on T cell activation threshold, cytokine production and proliferation. Modulates dendritic cell maturation toward a tolerogenic phenotype leading to generation of regulatory CD4-positive T cell subset with immune suppressive functions (PubMed:15802303, PubMed:16998493, PubMed:22213806). Acts as an endocytic pattern recognition receptor involved in antitumor immunity. During tumorigenesis, recognizes Tn antigens and its sialylated forms Neu5Ac-Tn and Neu5Gc-Tn expressed on tumor cell mucins. On immature dendritic cells, can internalize Tn-terminated immunogens and target them to endolysosomal compartment for MHC class I and II antigen presentation to CD8-positive and CD4-positive T cells, respectively (PubMed:15802303, PubMed:17616966, PubMed:17804752). {ECO:0000269|PubMed:15802303, ECO:0000269|PubMed:16998493, ECO:0000269|PubMed:17616966, ECO:0000269|PubMed:17804752, ECO:0000269|PubMed:22213806, ECO:0000269|PubMed:23507963, ECO:0000269|PubMed:33724805, ECO:0000269|PubMed:8598452}.
uniprot
proteins
mass_dalton
35446
uniprot
proteins
mutagenesis
MUTAGEN 5; /note="Y->A: Loss of receptor-mediated endocytosis."; /evidence="ECO:0000269|PubMed:17616966"; MUTAGEN 30; /note="L->A: 45% reduction of receptor-mediated endocytosis; when associated with A-31."; /evidence="ECO:0000269|PubMed:17616966"; MUTAGEN 31; /note="L->A: 45% reduction of receptor-mediated endocytosis; when associated with A-30."; /evidence="ECO:0000269|PubMed:17616966
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15802303
uniprot
proteins
pubmed
16998493
uniprot
proteins
pubmed
17616966
uniprot
proteins
pubmed
17804752
uniprot
proteins
pubmed
22213806
uniprot
proteins
pubmed
23507963
uniprot
proteins
pubmed
33724805
uniprot
proteins
pubmed
8598452
uniprot
proteins
sequence_length
316
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16998493, ECO:0000269|PubMed:17616966, ECO:0000269|PubMed:17804752}; Single-pass type II membrane protein. Early endosome membrane {ECO:0000269|PubMed:17616966}; Single-pass type II membrane protein. Lysosome membrane {ECO:0000269|PubMed:17616966}; Single-pass type II membrane protein. Note=Recycles between the plasma membrane and the endolysosomal compartment. Upon antigen binding, internalizes via endocytosis and then dissociates from antigen at acidic pH characteristic of endolysosomal vesicles. {ECO:0000269|PubMed:17616966}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..60; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins