Camk2a
entrez
25400
canonical
uniprot
P11275
canonical
ensembl
ENSRNOG00000018712
resolver
ensp
ENSRNOP00000093893
resolver
enst
ENSRNOT00000101374
resolver
genesymbol
Camk2a
resolver
uniprot
A0A8I6AKH1
resolver
uniprot_entry
A0A8I6AKH1_RAT
resolver
uniprot_entry
KCC2A_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-286 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity. {ECO:0000269|PubMed:2842767}.
uniprot
proteins
amino_acid_sequence
MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKSGGNKKNDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
uniprot
proteins
ec_number
2.7.11.17
uniprot
proteins
function
FUNCTION: Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (PubMed:15312654). Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (By similarity). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of PSAT1, inhibiting ferroptosis by promoting GPX4 hydroxylation and stability (By similarity). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity). {ECO:0000250|UniProtKB:P11798, ECO:0000250|UniProtKB:Q9UQM7, ECO:0000269|PubMed:11972023, ECO:0000269|PubMed:15312654}.
uniprot
proteins
mass_dalton
54115
uniprot
proteins
mutagenesis
MUTAGEN 432..435; /note="IRIT->MGTA: Loss of interaction with MPDZ."; /evidence="ECO:0000269|PubMed:15312654
uniprot
proteins
post_translational_modification
PTM: Autophosphorylation of Thr-286 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-286 locks the kinase into an activated state. {ECO:0000250|UniProtKB:Q9UQM7}.; PTM: Palmitoylated (PubMed:23687301). Probably palmitoylated by ZDHHC3 and ZDHHC7 (PubMed:23687301). {ECO:0000269|PubMed:23687301}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
CaMK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11182241
uniprot
proteins
pubmed
11972023
uniprot
proteins
pubmed
1328883
uniprot
proteins
pubmed
15312654
uniprot
proteins
pubmed
15659234
uniprot
proteins
pubmed
17923693
uniprot
proteins
pubmed
2153289
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23687301
uniprot
proteins
pubmed
2842767
uniprot
proteins
pubmed
2856087
uniprot
proteins
pubmed
3037704
uniprot
proteins
pubmed
3475713
uniprot
proteins
pubmed
9724800
uniprot
proteins
sequence_length
478
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Synapse {ECO:0000269|PubMed:15659234}. Postsynaptic density {ECO:0000269|PubMed:15659234}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q9UQM7}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9UQM7}. Note=Postsynaptic lipid rafts. {ECO:0000269|PubMed:15659234}.
uniprot
proteins