Chpf
entrez
74241
canonical
uniprot
Q6IQX7
canonical
ensembl
ENSMUSG00000032997
resolver
ensp
ENSMUSP00000078199
resolver
ensp
ENSMUSP00000092412
resolver
genesymbol
Chpf
resolver
genesymbol_syn
Css2
resolver
genesymbol_syn
D1Bwg1363e
resolver
uniprot
E9PUB9
resolver
uniprot_entry
CHSS2_MOUSE
resolver
uniprot_sec
E9PUB9
resolver
amino_acid_sequence
MRASLLLSVLRPAGPVAVGISLGFTLSLLSVTWVEEPCGPGPPQPGDSELPPRGNTNAARRPNSVQPGSERERPGAGAGTGESWEPRVLPYHPAQPGQATKKAVRTRYISTELGIRQKLLVAVLTSQATLPTLGVAVNRTLGHRLEHVVFLTGARGRRTPSGMAVVALGEERPIGHLHLALRHLLEQHGDDFDWFFLVPDATYTEAHGLDRLAGHLSLASATHLYLGRPQDFIGGDTTPGRYCHGGFGVLLSRTLLQQLRPHLESCRNDIVSARPDEWLGRCILDATGVGCTGDHEGMHYNYLELSPGEPVQEGDPRFRSALTAHPVRDPVHMYQLHKAFARAELDRTYQEIQELQWEIQNTSRLAADGERASAWPVGIPAPSRPASRFEVLRWDYFTEQYAFSCADGSPRCPLRGADQADVADVLGTALEELNRRYQPALQLQKQQLVNGYRRFDPARGMEYTLDLQLEALTPQGGRWPLTRRVQLLRPLSRVEILPVPYVTEASRLTVLLPLAAAERDLASGFLEAFATAALEPGDAAALTLLLLYEPRQAQRAAHSDVFAPVKAHVAELERRFPGARVPWLSVQTAAPSPLRLMDLLSKKHPLDTLFLLAGPDTVLTPDFLNRCRMHAISGWQAFFPMHFQAFHPAVAPPQGPGPPELGRDTGHFDRQAASEACFYNSDYVAARGRLVAASEQEEELLESLDVYELFLRFSNLHVLRAVEPALLQRYRAQPCSARLSEDLYHRCRQSVLEGLGSRTQLAMLLFEQEQGNST
uniprot
proteins
function
FUNCTION: Non-catalytic component of CHSY1-CHPF2 and CHSY3-CHPF2 chondroitin sulfate synthase complexes. CHPF associates with catalytically active chondroitin synthases (CHSY1/3) within heterodimeric complexes and likely plays a structural or stabilizing role in chondroitin sulfate chain polymerization. Seems to act as a specific activating factor for CHSY1 in chondroitin polymerization. {ECO:0000250|UniProtKB:Q8IZ52}.; FUNCTION: [Isoform 2]: May facilitate PRKN transport into the mitochondria. In collaboration with PRKN, may enhance cell viability and protect cells from oxidative stress. {ECO:0000250|UniProtKB:Q8IZ52}.
uniprot
proteins
mass_dalton
85534
uniprot
proteins
protein_family
Chondroitin N-acetylgalactosaminyltransferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22082830
uniprot
proteins
sequence_length
774
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q8IZ52}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q8IZ52}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8IZ52}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8IZ52}. Mitochondrion {ECO:0000250|UniProtKB:Q8IZ52}.; SUBCELLULAR LOCATION: [Isoform 2]: Mitochondrion matrix {ECO:0000250|UniProtKB:Q8IZ52}.
uniprot
proteins
transmembrane_region
TRANSMEM 16..34; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins