ALDH8A1
entrez
64577
canonical
uniprot
Q9H2A2
canonical
ensembl
ENSG00000118514
resolver
ensp
ENSP00000265605
resolver
ensp
ENSP00000356819
resolver
ensp
ENSP00000356821
resolver
genesymbol
ALDH8A1
resolver
genesymbol_syn
ALDH12
resolver
hgnc
HGNC:15471
resolver
uniprot
B7Z521
resolver
uniprot
O60793
resolver
uniprot
Q24JS9
resolver
uniprot
Q53GT3
resolver
uniprot
Q5TI80
resolver
uniprot_entry
AL8A1_HUMAN
resolver
uniprot_sec
B7Z521
resolver
uniprot_sec
O60793
resolver
uniprot_sec
Q24JS9
resolver
uniprot_sec
Q53GT3
resolver
uniprot_sec
Q5TI80
resolver
amino_acid_sequence
MAGTNALLMLENFIDGKFLPCSSYIDSYDPSTGEVYCRVPNSGKDEIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLALARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYLLTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVSHPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSFANQGEICLCTSRIFVQKSIYSEFLKRFVEATRKWKVGIPSDPLVSIGALISKAHLEKVRSYVKRALAEGAQIWCGEGVDKLSLPARNQAGYFMLPTVITDIKDESCCMTEEIFGPVTCVVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNLPFGGMKSSGIGREGAKDSYDFFTEIKTITVKH
uniprot
proteins
ec_number
1.2.1.32
uniprot
proteins
function
FUNCTION: Catalyzes the NAD-dependent oxidation of 2-aminomuconic semialdehyde of the kynurenine metabolic pathway in L-tryptophan degradation. {ECO:0000269|PubMed:29703752}.
uniprot
proteins
mass_dalton
53401
uniprot
proteins
mutagenesis
MUTAGEN 109; /note="R->A: About 65-fold loss of catalytic efficiency."; /evidence="ECO:0000269|PubMed:29703752"; MUTAGEN 155; /note="N->A: Complete loss of activity."; /evidence="ECO:0000269|PubMed:29703752"; MUTAGEN 451; /note="R->A: Complete loss of activity."; /evidence="ECO:0000269|PubMed:29703752
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid degradation; L-kynurenine degradation. {ECO:0000305|PubMed:29703752}.
uniprot
proteins
protein_family
Aldehyde dehydrogenase family
uniprot
proteins
pubmed
11007799
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29703752
uniprot
proteins
sequence_length
487
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins