CA9
entrez
768
canonical
uniprot
Q16790
canonical
ensembl
ENSG00000107159
resolver
ensp
ENSP00000367608
resolver
enst
ENST00000378357
resolver
genesymbol
CA9
resolver
genesymbol_syn
G250
resolver
genesymbol_syn
MN
resolver
hgnc
HGNC:1383
resolver
uniprot
A0A0S2Z341
resolver
uniprot
A0A0S2Z3D0
resolver
uniprot
Q5T4R1
resolver
uniprot_entry
A0A0S2Z341_HUMAN
resolver
uniprot_entry
A0A0S2Z3D0_HUMAN
resolver
uniprot_entry
CAH9_HUMAN
resolver
uniprot_sec
Q5T4R1
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by coumarins, saccharin, Foscarnet (phosphonoformate trisodium salt), and sulfonamide derivatives such as acetazolamide (AZA), ethoxzolamide and benzolamide. {ECO:0000269|PubMed:11676494, ECO:0000269|PubMed:17314045, ECO:0000269|PubMed:17705204, ECO:0000269|PubMed:18703501, ECO:0000269|PubMed:19186056, ECO:0000269|PubMed:19206230, ECO:0000269|PubMed:19805286}.
uniprot
proteins
amino_acid_sequence
MAPLCPSPWLPLLIPAPAPGLTVQLLLSLLLLVPVHPQRLPRMQEDSPLGGGSSGEDDPLGEEDLPSEEDSPREEDPPGEEDLPGEEDLPGEEDLPEVKPKSEEEGSLKLEDLPTVEAPGDPQEPQNNAHRDKEGDDQSHWRYGGDPPWPRVSPACAGRFQSPVDIRPQLAAFCPALRPLELLGFQLPPLPELRLRNNGHSVQLTLPPGLEMALGPGREYRALQLHLHWGAAGRPGSEHTVEGHRFPAEIHVVHLSTAFARVDEALGRPGGLAVLAAFLEEGPEENSAYEQLLSRLEEIAEEGSETQVPGLDISALLPSDFSRYFQYEGSLTTPPCAQGVIWTVFNQTVMLSAKQLHTLSDTLWGPGDSRLQLNFRATQPLNGRVIEASFPAGVDSSPRAAEPVQLNSCLAAGDILALVFGLLFAVTSVAFLVQMRRQHRRGTKGGVSYRPAEVAETGA
uniprot
proteins
ec_number
4.2.1.1
uniprot
proteins
function
FUNCTION: Catalyzes the interconversion between carbon dioxide and water and the dissociated ions of carbonic acid (i.e. bicarbonate and hydrogen ions). {ECO:0000269|PubMed:11676494, ECO:0000269|PubMed:17314045, ECO:0000269|PubMed:17705204, ECO:0000269|PubMed:18703501, ECO:0000269|PubMed:19186056, ECO:0000269|PubMed:19206230, ECO:0000269|PubMed:19805286}.
uniprot
proteins
mass_dalton
49698
uniprot
proteins
post_translational_modification
PTM: Asn-346 bears high-mannose type glycan structures. {ECO:0000269|PubMed:19805286}.
uniprot
proteins
protein_family
Alpha-carbonic anhydrase family
uniprot
proteins
pubmed
10709109
uniprot
proteins
pubmed
11676494
uniprot
proteins
pubmed
1312272
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16310354
uniprot
proteins
pubmed
17314045
uniprot
proteins
pubmed
17705204
uniprot
proteins
pubmed
18041760
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18703501
uniprot
proteins
pubmed
19186056
uniprot
proteins
pubmed
19206230
uniprot
proteins
pubmed
19805286
uniprot
proteins
pubmed
8084592
uniprot
proteins
pubmed
8486430
uniprot
proteins
sequence_length
459
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8486430}. Nucleus, nucleolus {ECO:0000269|PubMed:8486430}. Cell membrane {ECO:0000269|PubMed:8486430}; Single-pass type I membrane protein {ECO:0000269|PubMed:8486430}. Cell projection, microvillus membrane {ECO:0000269|PubMed:8486430}; Single-pass type I membrane protein {ECO:0000269|PubMed:8486430}. Note=Found on the surface microvilli and in the nucleus, particularly in nucleolus.
uniprot
proteins
transmembrane_region
TRANSMEM 415..435; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins