Marchf7
entrez
311059
canonical
uniprot
Q5XI50
canonical
ensembl
ENSRNOG00000006241
resolver
ensp
ENSRNOP00000104276
resolver
ensp
ENSRNOP00000110946
resolver
enst
ENSRNOT00000127891
resolver
enst
ENSRNOT00000173416
resolver
genesymbol
Marchf7
resolver
genesymbol_syn
March7
resolver
uniprot
A0ABK0M6L9
resolver
uniprot_entry
A0ABK0M6L9_RAT
resolver
uniprot_entry
MARH7_RAT
resolver
amino_acid_sequence
MESKPSRIPRRISVQPSGSLSARMVSGNRGTSLNDSYHSRDSSFRLDSEYQSASASASASPYQSTWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTSTSAGRNIGSGLNTLSDSSWRPGQVPRSSSMVLGSFGTDLMRERRDLERRRDSSISSLMDYSHRSGDFTAPAYVQERVPSSYSQGARPKENAANTLQLNSSTNHQLPSEHQTVPSSRDSSRSSFRSHFSPRQSESFRNSSHPAFSYLSSRNETPTISSSERAGSSQRPFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSSQDSLNTRSLSSENYISPRTLTSQSRNNGASSSEVNDGRASEASQGFRFLRRRWGLSSLSQNHSSEPDAENFNQESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRISPSDVPPRSHLFRRESNEVVHLEAQGDSLGAAASRPQASGASGNASASGSTPDLPQGGRNTGIAGILPGSLFRFAVPPALGSNLTDNVTITVDIIPSGWSSADGKSEKAKSAPSRDPEKLQKIKESLLLEDSDEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQECMKKWLQAKINSGSSLEAVTTCELCKEKLQLNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGNTIEPSTRVRFINLARTLQAHMEDLETSEDEF
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (By similarity). May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis. Promotes 'Lys-6', 'Lys-11' and 'Lys-63'-linked mixed polyubiquitination on ATG14 leading to the inhibition of autophagy by impairing the interaction between ATG14 and STX7. Participates in the dopamine-mediated negative regulation of the NLRP3 inflammasome by promoting its ubiquitination and subsequent degradation (By similarity). {ECO:0000250|UniProtKB:Q9H992, ECO:0000250|UniProtKB:Q9WV66}.
uniprot
proteins
mass_dalton
76351
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
692
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H992}.
uniprot
proteins