Cenpt
entrez
320394
canonical
uniprot
Q3TJM4
canonical
ensembl
ENSMUSG00000036672
resolver
ensp
ENSMUSP00000038188
resolver
ensp
ENSMUSP00000253676
resolver
enst
ENSMUST00000040776
resolver
genesymbol
Cenpt
resolver
uniprot
Q3TPY6
resolver
uniprot
Q3UPD2
resolver
uniprot
Q8BTH0
resolver
uniprot
Q8BTP2
resolver
uniprot
Q8R5E9
resolver
uniprot_entry
CENPT_MOUSE
resolver
uniprot_sec
Q3TPY6
resolver
uniprot_sec
Q3UPD2
resolver
uniprot_sec
Q8BTH0
resolver
uniprot_sec
Q8BTP2
resolver
uniprot_sec
Q8R5E9
resolver
amino_acid_sequence
MADLSFSDGDPTVRTLLRRVLETADSRTPMRRRSTRINAQRRRSQTPYSNRQGSQTKTSARKQSHGARSVGRSTRVQGRGRLEEQTPRTLLRNILLTAPESSTVMPDPVVKPAQVPEVARSSRRESSRGSLELHLPELEPPSTLAPGLTAPGKRKQKLRLSVFQQEVDQGLPLSQEPRRSRSADVSSLASSFNLTFVLPGQPETVERPGLARRRPIRQLVNAGALLQDLEDNSLASALPGDSHRTPVAALPMDVGLEDTQPFSQSLAAFSLSGKHSLPSPSRPGVEDVERVMGPPSSGTRLQSRMSRSGPAASPSPFLEPQPPPAEPREAVGSNEAAEPKDQEGSSGYEETSARPASGELSSSTHDSLPAEQPPPSPGVAVLSSEPLESVTAKCPSRTQTAGPRRRQDPHKAGLSPYVKFFSFCTKMPVEKTALEIVEKCLDKYFQHLCNDLEVFASHAGRKIVKPEDLLLLMRRQGLVTDQVSQHVLVERYLPLEYRQQLIPCAFSGNSVFPAQ
uniprot
proteins
function
FUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP-T-W-S-X complex that binds and supercoils DNA, and plays an important role in kinetochore assembly. CENPT has a fundamental role in kinetochore assembly and function. It is one of the inner kinetochore proteins, with most further proteins binding downstream. Required for normal chromosome organization and normal progress through mitosis. {ECO:0000250|UniProtKB:Q96BT3}.
uniprot
proteins
mass_dalton
56242
uniprot
proteins
post_translational_modification
PTM: Dynamically phosphorylated during the cell cycle. Phosphorylated during G2 phase, metaphase and anaphase, but not during telophase or G1 phase. {ECO:0000250|UniProtKB:Q96BT3}.
uniprot
proteins
protein_family
CENP-T/CNN1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
515
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96BT3}. Chromosome, centromere {ECO:0000250|UniProtKB:Q96BT3}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q96BT3}. Note=Constitutively localizes to centromeres throughout the cell cycle, and to kinetochores during mitosis. Localizes to the inner kinetochore, and may connect it to the outer kinetochore via its N-terminus. {ECO:0000250|UniProtKB:Q96BT3}.
uniprot
proteins