Aunip
entrez
689656
canonical
uniprot
D3ZUC4
canonical
ensembl
ENSRNOG00000022030
resolver
ensembl
ENSRNOG00055026565
resolver
ensp
ENSRNOP00000032347
resolver
ensp
ENSRNOP00055037569
resolver
enst
ENSRNOT00000039322
resolver
enst
ENSRNOT00055045834
resolver
genesymbol
Aunip
resolver
uniprot_entry
AUNIP_RAT
resolver
amino_acid_sequence
MSRRGPEEEACGVWLDAAALKRQKMQTHLLKLGTKMLTLLPGERKPSIPFTQRRATRQTSITSFVTSQPGMANGGNQKNASSLKENQINRECKSRSQLDCLDQGLEDDCLVSPLATSTPADIREAGHSPQSSQISGCQSLETTSLTMMSFPQPVVLMGTGESKAPLASSFTQFLERSCLLDQREAKRKREGLCGSKTDCPGMGSHIRPPGGKCHQPLDKAKVEKRATAKENRQAPVHLQTYRFGSHSGKKTLLVTKSPCPLSVFSWDIDRKDRDSWSQLFTEDSQGHQVIAHSTKMPFQDVTNARNQGSGQFPDSPQAQGQDGPTLLHLQPHLLFTQDSEGNRVIRH
uniprot
proteins
function
FUNCTION: DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination. Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair. Inhibits non-homologous end joining (NHEJ). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle. {ECO:0000250|UniProtKB:Q9H7T9}.
uniprot
proteins
mass_dalton
38244
uniprot
proteins
protein_family
AUNIP family
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
347
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H7T9}. Chromosome {ECO:0000250|UniProtKB:Q9H7T9}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9H7T9}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q9H7T9}. Note=Accumulates at sites of DNA damage by binding to DNA substrates that mimick structures generated at stalled replication forks. Localizes to the centrosome in interphase and to the spindle pole in metaphase. {ECO:0000250|UniProtKB:Q9H7T9}.
uniprot
proteins