Pgrmc2
entrez
70804
canonical
uniprot
Q80UU9
canonical
ensembl
ENSMUSG00000049940
resolver
ensp
ENSMUSP00000056643
resolver
enst
ENSMUST00000058578
resolver
genesymbol
Pgrmc2
resolver
uniprot_entry
PGRC2_MOUSE
resolver
amino_acid_sequence
MAAGDGDVKLSTLGSGGESGGDGSPGGAGATAARSSWVAALLATGGEMLLNVALVALVLLGAYRLWVRWGRRGLCSGPGAGEESPAATLPRMKKRDFSLEQLRQYDGARTPRILLAVNGKVFDVTKGSKFYGPAGPYGIFAGRDASRGLATFCLDKDALRDEYDDLSDLNAVQMESVREWEMQFKEKYDYVGRLLKPGEEPSEYTDEEDTKDHSKQD
uniprot
proteins
function
FUNCTION: Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (PubMed:28005395). May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus. Plays a role in adipocyte function and systemic glucose homeostasis. In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (PubMed:31748741). {ECO:0000269|PubMed:28005395, ECO:0000269|PubMed:31748741, ECO:0000305|PubMed:28005395}.
uniprot
proteins
mass_dalton
23334
uniprot
proteins
protein_family
Cytochrome b5 family
uniprot
proteins
protein_family
MAPR subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28005395
uniprot
proteins
pubmed
31748741
uniprot
proteins
sequence_length
217
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Nucleus envelope {ECO:0000250|UniProtKB:O15173}. Endoplasmic reticulum {ECO:0000250|UniProtKB:O15173}. Secreted {ECO:0000250|UniProtKB:O15173}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..62; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins