Q7TP90
uniprot
Q7TP90
canonical
amino_acid_sequence
MSSQSSILVDFRPLATSFTGKYGSIQYCVRAVLERPQVPDQSVRRELQVVSHVDVNTPPLLTPMLKTQEKMVGCWLFTSGPVSLSVKIERKGYCNGEAIPIYAEIENCSSRLVVPKAAIFQTQTYLASGKTKTVRHMVANVRGNHIGSGSTDTWNGKMLKIPPVTPSILDCCIIRVYIHIPGAKKLMLELPLVIGTIPYSGFGRRNSSMASQFSMDMCWLALALPEQPEAPPNYADVVSEEEFSRHIPPYPQPSACDGEACYSMFACIQEFRFQPPPLYSESHAQLFCLQPVGPTNRAHF
uniprot
proteins
function
FUNCTION: Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates. Plays a role in endocytosis of activated G protein-coupled receptors (GPCRs) Through an ubiquitination-dependent mechanism also plays a role in the incorporation of SLC11A2 into extracellular vesicles. May play a role in glucose uptake. Participates in innate immune response by promoting IFIH1/MDA5 activation through interaction with TRIM65. {ECO:0000250|UniProtKB:A0A0B4J1F4}.
uniprot
proteins
mass_dalton
33275
uniprot
proteins
protein_family
Arrestin family
uniprot
proteins
sequence_length
300
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome {ECO:0000250|UniProtKB:Q8NCT1}. Cell membrane {ECO:0000250|UniProtKB:Q8NCT1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8NCT1}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8NCT1}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q8NCT1}. Note=Also found in extracellular vesicles different from exosomes. {ECO:0000250|UniProtKB:A0A0B4J1F4}.
uniprot
proteins