NECTIN3
entrez
25945
canonical
uniprot
Q9NQS3
canonical
ensembl
ENSG00000177707
resolver
ensp
ENSP00000321514
resolver
ensp
ENSP00000418070
resolver
ensp
ENSP00000420579
resolver
ensp
ENSP00000688359
resolver
genesymbol
NECTIN3
resolver
genesymbol_syn
PRR3
resolver
genesymbol_syn
PVRL3
resolver
hgnc
HGNC:17664
resolver
uniprot
E9PFR0
resolver
uniprot
Q6NVZ3
resolver
uniprot
Q8NC05
resolver
uniprot
Q8WVU4
resolver
uniprot
Q9BVA9
resolver
uniprot
Q9Y412
resolver
uniprot_entry
NECT3_HUMAN
resolver
uniprot_sec
E9PFR0
resolver
uniprot_sec
Q6NVZ3
resolver
uniprot_sec
Q8NC05
resolver
uniprot_sec
Q8WVU4
resolver
uniprot_sec
Q9BVA9
resolver
uniprot_sec
Q9Y412
resolver
amino_acid_sequence
MARTLRPSPLCPGGGKAQLSSASLLGAGLLLQPPTPPPLLLLLFPLLLFSRLCGALAGPIIVEPHVTAVWGKNVSLKCLIEVNETITQISWEKIHGKSSQTVAVHHPQYGFSVQGEYQGRVLFKNYSLNDATITLHNIGFSDSGKYICKAVTFPLGNAQSSTTVTVLVEPTVSLIKGPDSLIDGGNETVAAICIAATGKPVAHIDWEGDLGEMESTTTSFPNETATIISQYKLFPTRFARGRRITCVVKHPALEKDIRYSFILDIQYAPEVSVTGYDGNWFVGRKGVNLKCNADANPPPFKSVWSRLDGQWPDGLLASDNTLHFVHPLTFNYSGVYICKVTNSLGQRSDQKVIYISDPPTTTTLQPTIQWHPSTADIEDLATEPKKLPFPLSTLATIKDDTIATIIASVVGGALFIVLVSVLAGIFCYRRRRTFRGDYFAKNYIPPSDMQKESQIDVLQQDELDSYPDSVKKENKNPVNNLIRKDYLEEPEKTQWNNVENLNRFERPMDYYEDLKMGMKFVSDEHYDENEDDLVSHVDGSVISRREWYV
uniprot
proteins
function
FUNCTION: Cell adhesion molecule that promotes cell-cell adhesion through heterophilic trans-interactions with nectins-like or other nectins, such as trans-interaction with NECTIN2 at Sertoli-spermatid junctions (PubMed:16216929). Trans-interaction with PVR induces activation of CDC42 and RAC small G proteins through common signaling molecules such as SRC and RAP1 (PubMed:16216929). Induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation (PubMed:16216929). Involved in axon guidance by promoting contacts between the commissural axons and the floor plate cells (By similarity). Also involved in the formation of cell-cell junctions, including adherens junctions and synapses (By similarity). Promotes formation of checkerboard-like cellular pattern of hair cells and supporting cells in the auditory epithelium via heterophilic interaction with NECTIN1: NECTIN1 is present in the membrane of hair cells and associates with NECTIN3 on supporting cells, thereby mediating heterotypic adhesion between these two cell types (By similarity). Plays a role in the morphology of the ciliary body (By similarity). {ECO:0000250|UniProtKB:Q9JLB9, ECO:0000269|PubMed:16216929}.
uniprot
proteins
mass_dalton
61002
uniprot
proteins
protein_family
Nectin family
uniprot
proteins
pubmed
11024295
uniprot
proteins
pubmed
12759359
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16216929
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19011627
uniprot
proteins
pubmed
22902367
uniprot
proteins
pubmed
26038560
uniprot
proteins
pubmed
27680706
uniprot
proteins
sequence_length
549
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26038560}; Single-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9JLB9}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9JLB9}. Note=In the auditory epithelium, specificaly localizes to the apical side of the lateral membranes of supporting cells. {ECO:0000250|UniProtKB:Q9JLB9}.
uniprot
proteins
transmembrane_region
TRANSMEM 405..425; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins