Txnip
entrez
56338
canonical
uniprot
Q8BG60
canonical
ensembl
ENSMUSG00000038393
resolver
ensp
ENSMUSP00000041467
resolver
ensp
ENSMUSP00000102710
resolver
genesymbol
Txnip
resolver
genesymbol_syn
Vdup1
resolver
uniprot
Q8BGQ0
resolver
uniprot
Q8K2B2
resolver
uniprot
Q9DC00
resolver
uniprot
Q9EP90
resolver
uniprot
Q9R115
resolver
uniprot_entry
TXNIP_MOUSE
resolver
uniprot_sec
Q8BGQ0
resolver
uniprot_sec
Q8K2B2
resolver
uniprot_sec
Q9DC00
resolver
uniprot_sec
Q9EP90
resolver
uniprot_sec
Q9R115
resolver
amino_acid_sequence
MVMFKKIKSFEVVFNDPEKVYGSGEKVAGRVIVEVCEVTRVKAVRILACGVAKVLWMQGSQQCKQTLDYLRYEDTLLLEEQPTAGENEMVIMRPGNKYEYKFGFELPQGPLGTSFKGKYGCVDYWVKAFLDRPSQPTQEAKKNFEVMDLVDVNTPDLMAPVSAKKEKKVSCMFIPDGRVSVSARIDRKGFCEGDDISIHADFENTCSRIVVPKAAIVARHTYLANGQTKVFTQKLSSVRGNHIISGTCASWRGKSLRVQKIRPSILGCNILKVEYSLLIYVSVPGSKKVILDLPLVIGSRSGLSSRTSSMASRTSSEMSWIDLNIPDTPEAPPCYMDIIPEDHRLESPTTPLLDDVDDSQDSPIFMYAPEFQFMPPPTYTEVDPCVLNNNNNNNNVQ
uniprot
proteins
function
FUNCTION: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability (PubMed:10843682). Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm (PubMed:15930262). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest (By similarity). Required for the maturation of natural killer cells (PubMed:15723808). Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). {ECO:0000250|UniProtKB:Q9H3M7, ECO:0000269|PubMed:10843682, ECO:0000269|PubMed:15723808, ECO:0000269|PubMed:15930262}.
uniprot
proteins
mass_dalton
44363
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated; undergoes heterotypic 'Lys-48'-/'Lys-63'-branched polyubiquitination catalyzed by ITCH and UBR5 resulting in proteasomal degradation. Deubiquitinated by USP5, leading to TXNIP stabilization. {ECO:0000250|UniProtKB:Q9H3M7}.
uniprot
proteins
protein_family
Arrestin family
uniprot
proteins
pubmed
10843682
uniprot
proteins
pubmed
11376942
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15723808
uniprot
proteins
pubmed
15930262
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
397
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10843682}.
uniprot
proteins