NUDT7
entrez
283927
canonical
uniprot
P0C024
canonical
ensembl
ENSG00000140876
resolver
ensp
ENSP00000268533
resolver
ensp
ENSP00000387707
resolver
ensp
ENSP00000457566
resolver
ensp
ENSP00000479582
resolver
enst
ENST00000613075
resolver
genesymbol
NUDT7
resolver
hgnc
HGNC:8054
resolver
uniprot
A0A087WVP7
resolver
uniprot
B4DLE5
resolver
uniprot
H3BUB8
resolver
uniprot_entry
A0A087WVP7_HUMAN
resolver
uniprot_entry
NUDT7_HUMAN
resolver
uniprot_sec
B4DLE5
resolver
uniprot_sec
H3BUB8
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by fluoride. {ECO:0000250|UniProtKB:Q99P30}.
uniprot
proteins
amino_acid_sequence
MSRLGLPEEPVRNSLLDDAKARLRKYDIGGKYSHLPYNKYSVLLPLVAKEGKLHLLFTVRSEKLRRAPGEVCFPGGKRDPTDMDDAATALREAQEEVGLRPHQVEVVCCLVPCLIDTDTLITPFVGLIDHNFQAQPNPAEVKDVFLVPLAYFLHPQVHDQHYVTRLGHRFINHIFEYTNPEDGVTYQIKGMTANLAVLVAFIILEKKPTFEVQFNLNDVLASSEELFLKVHKKATSRL
uniprot
proteins
ec_number
3.6.1.-
uniprot
proteins
ec_number
3.6.1.77
uniprot
proteins
function
FUNCTION: Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Cleaves CoA, CoA esters and oxidized CoA with similar efficiencies (By similarity). Preferentially hydrolyzes medium-chain acyl-CoAs and bile acid-CoAs (By similarity). Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester (By similarity). May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand (By similarity). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity). {ECO:0000250|UniProtKB:Q99P30}.
uniprot
proteins
mass_dalton
26942
uniprot
proteins
protein_family
Nudix hydrolase family
uniprot
proteins
protein_family
PCD1 subfamily
uniprot
proteins
pubmed
11415433
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15616553
uniprot
proteins
sequence_length
238
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome {ECO:0000250|UniProtKB:Q99P30}.
uniprot
proteins