MEPE
entrez
56955
canonical
uniprot
Q9NQ76
canonical
ensembl
ENSG00000152595
resolver
ensp
ENSP00000354341
resolver
ensp
ENSP00000378534
resolver
ensp
ENSP00000416984
resolver
genesymbol
MEPE
resolver
hgnc
HGNC:13361
resolver
uniprot
A1A4X9
resolver
uniprot
A8MTA3
resolver
uniprot
D2CFR4
resolver
uniprot
F5H5C5
resolver
uniprot
Q8NC19
resolver
uniprot_entry
MEPE_HUMAN
resolver
uniprot_entry
Q8NC19_HUMAN
resolver
uniprot_sec
A1A4X9
resolver
uniprot_sec
A8MTA3
resolver
uniprot_sec
D2CFR4
resolver
uniprot_sec
F5H5C5
resolver
amino_acid_sequence
MRVFCVGLLLFSVTWAAPTFQPQTEKTKQSCVEEQRQEEKNKDNIGFHHLGKRINQELSSKENIVQERKKDLSLSEASENKGSSKSQNYFTNRQRLNKEYSISNKENTHNGLRMSIYPKSTGNKGFEDGDDAISKLHDQEEYGAALIRNNMQHIMGPVTAIKLLGEENKENTPRNVLNIIPASMNYAKAHSKDKKKPQRDSQAQKSPVKSKSTHRIQHNIDYLKHLSKVKKIPSDFEGSGYTDLQERGDNDISPFSGDGQPFKDIPGKGEATGPDLEGKDIQTGFAGPSEAESTHLDTKKPGYNEIPEREENGGNTIGTRDETAKEADAVDVSLVEGSNDIMGSTNFKELPGREGNRVDAGSQNAHQGKVEFHYPPAPSKEKRKEGSSDAAESTNYNEIPKNGKGSTRKGVDHSNRNQATLNEKQRFPSKGKSQGLPIPSRGLDNEIKNEMDSFNGPSHENIITHGRKYHYVPHRQNNSTRNKGMPQGKGSWGRQPHSNRRFSSRRRDDSSESSDSGSSSESDGD
uniprot
proteins
function
FUNCTION: Promotes renal phosphate excretion and inhibits intestinal phosphate absorption (PubMed:14962809, PubMed:19005008). Promotes bone mineralization by osteoblasts and cartilage mineralization by chondrocytes (PubMed:18162525, PubMed:19998030, PubMed:22766095). Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage (By similarity). Promotes dental pulp stem cell proliferation and differentiation (PubMed:22341070). {ECO:0000250|UniProtKB:Q8K4L6, ECO:0000269|PubMed:14962809, ECO:0000269|PubMed:18162525, ECO:0000269|PubMed:19005008, ECO:0000269|PubMed:19998030, ECO:0000269|PubMed:22341070, ECO:0000269|PubMed:22766095}.
uniprot
proteins
mass_dalton
58419
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine residues in the ASARM motif (in vitro) by FAM20C; the phosphorylation is important for the inhibition of bone mineralization (PubMed:19998030, PubMed:22582013). {ECO:0000269|PubMed:19998030, ECO:0000269|PubMed:22582013}.; PTM: Cleaved by CTSB/cathepsin B; the cleavage is blocked by metalloprotease PHEX. {ECO:0000269|PubMed:12220505}.
uniprot
proteins
protein_family
PF07175/osteoregulin family
uniprot
proteins
pubmed
10945470
uniprot
proteins
pubmed
11414762
uniprot
proteins
pubmed
12220505
uniprot
proteins
pubmed
12489176
uniprot
proteins
pubmed
14962809
uniprot
proteins
pubmed
15040834
uniprot
proteins
pubmed
15108058
uniprot
proteins
pubmed
15153459
uniprot
proteins
pubmed
15329369
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15664000
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18162525
uniprot
proteins
pubmed
18547474
uniprot
proteins
pubmed
18597632
uniprot
proteins
pubmed
19005008
uniprot
proteins
pubmed
19998030
uniprot
proteins
pubmed
20581062
uniprot
proteins
pubmed
22341070
uniprot
proteins
pubmed
22582013
uniprot
proteins
pubmed
22766095
uniprot
proteins
pubmed
37453717
uniprot
proteins
sequence_length
525
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:11414762, ECO:0000269|PubMed:15108058}. Secreted {ECO:0000269|PubMed:37453717}.
uniprot
proteins