NRG3
entrez
10718
canonical
uniprot
P56975
canonical
ensembl
ENSG00000185737
resolver
ensp
ENSP00000361214
resolver
ensp
ENSP00000361215
resolver
ensp
ENSP00000384796
resolver
ensp
ENSP00000441201
resolver
ensp
ENSP00000451376
resolver
genesymbol
NRG3
resolver
hgnc
HGNC:7999
resolver
uniprot
A4D7U1
resolver
uniprot
B3KVG8
resolver
uniprot
B9EGV5
resolver
uniprot
D9ZHP6
resolver
uniprot
Q0PEH2
resolver
uniprot
Q5VYH3
resolver
uniprot_entry
B3KVG8_HUMAN
resolver
uniprot_entry
B9EGV5_HUMAN
resolver
uniprot_entry
D9ZHP6_HUMAN
resolver
uniprot_entry
NRG3_HUMAN
resolver
uniprot_sec
A4D7U1
resolver
uniprot_sec
Q0PEH2
resolver
uniprot_sec
Q5VYH3
resolver
amino_acid_sequence
MSEGAAAASPPGAASAAAASAEEGTAAAAAAAAAGGGPDGGGEGAAEPPRELRCSDCIVWNRQQTWLCVVPLFIGFIGLGLSLMLLKWIVVGSVKEYVPTDLVDSKGMGQDPFFLSKPSSFPKAMETTTTTTSTTSPATPSAGGAASSRTPNRISTRLTTITRAPTRFPGHRVPIRASPRSTTARNTAAPATVPSTTAPFFSSSTLGSRPPVPGTPSTQAMPSWPTAAYATSSYLHDSTPSWTLSPFQDAASSSSSSSSSATTTTPETSTSPKFHTTTYSTERSEHFKPCRDKDLAYCLNDGECFVIETLTGSHKHCRCKEGYQGVRCDQFLPKTDSILSDPTDHLGIEFMESEEVYQRQVLSISCIIFGIVIVGMFCAAFYFKSKKQAKQIQEQLKVPQNGKSYSLKASSTMAKSENLVKSHVQLQNYSKVERHPVTALEKMMESSFVGPQSFPEVPSPDRGSQSVKHHRSLSSCCSPGQRSGMLHRNAFRRTPPSPRSRLGGIVGPAYQQLEESRIPDQDTIPCQGIEVRKTISHLPIQLWCVERPLDLKYSSSGLKTQRNTSINMQLPSRETNPYFNSLEQKDLVGYSSTRASSVPIIPSVGLEETCLQMPGISEVKSIKWCKNSYSADVVNVSIPVSDCLIAEQQEVKILLETVQEQIRILTDARRSEDYELASVETEDSASENTAFLPLSPTAKSEREAQFVLRNEIQRDSALTK
uniprot
proteins
function
FUNCTION: Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes. {ECO:0000269|PubMed:16478787, ECO:0000269|PubMed:9275162}.
uniprot
proteins
mass_dalton
77901
uniprot
proteins
post_translational_modification
PTM: Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form.; PTM: Extensive glycosylation precedes the proteolytic cleavage (By similarity). Isoform 3 is glycosylated. {ECO:0000250, ECO:0000269|PubMed:16478787}.
uniprot
proteins
protein_family
Neuregulin family
uniprot
proteins
pubmed
10867024
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
16478787
uniprot
proteins
pubmed
9275162
uniprot
proteins
sequence_length
720
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Pro-neuregulin-3, membrane-bound isoform]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Does not seem to be active. {ECO:0000250}.; SUBCELLULAR LOCATION: [Neuregulin-3]: Secreted {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane; Single-pass type I membrane protein. Note=Isoform 3 is also proteolytically released as a soluble form.
uniprot
proteins
transmembrane_region
TRANSMEM 361..381; /note="Helical; Note=Internal signal sequence"; /evidence="ECO:0000255
uniprot
proteins