Kng1
entrez
16644
canonical
uniprot
O08677
canonical
ensembl
ENSMUSG00000022875
resolver
ensp
ENSMUSP00000023589
resolver
ensp
ENSMUSP00000040485
resolver
ensp
ENSMUSP00000087346
resolver
ensp
ENSMUSP00000228197
resolver
enst
ENSMUST00000023589
resolver
enst
ENSMUST00000089902
resolver
genesymbol
Kng1
resolver
genesymbol_syn
Kng
resolver
uniprot
A0A0R4J038
resolver
uniprot
D3YTY9
resolver
uniprot
O08676
resolver
uniprot
Q32MX7
resolver
uniprot
Q6S9I1
resolver
uniprot
Q91XK5
resolver
uniprot_entry
A0A0R4J038_MOUSE
resolver
uniprot_entry
D3YTY9_MOUSE
resolver
uniprot_entry
KNG1_MOUSE
resolver
uniprot_sec
O08676
resolver
uniprot_sec
Q32MX7
resolver
uniprot_sec
Q6S9I1
resolver
uniprot_sec
Q91XK5
resolver
amino_acid_sequence
MKLITTLLLCSGLLLTLTQGEEAQEIDCNDEAVFQAVDFSLKQFNPGVKSGNQYMLHRVIEGTKTDGSPTFYSFKYLIKEGNCSAQSGLAWQDCDFKDAEEAATGECTATVGKRENEFFIVTQTCKIAPSKAPILKAYFPCIGCVHAISTDSPDLEPVLKHSIEHFNNNTDHSHLFTLRKVKSAHRQVVAGLNFDITYTIVQTNCSKERFPSLHGDCVALPNGDDGECRGNLFMDINNKIANFSQSCTLYSGDDLVEALPKPCPGCPRDIPVDSPELKEVLGHSIAQLNAENDHPFYYKIDTVKKATSQVVAGTKYVIEFIARETKCSKESNTELAEDCEIKHLGQSLDCNANVYMRPWENKVVPTVKCQALDMTEMARRPPGFSPFRSVTVQETKEGRTVSPPYIAREQEERDAETEQGPTHGHGWLHEKQIKANKNHRGHKHGHDHGHWSPRRHGLGHGHQKPHGLGHGHQLKLDYLRHQREDGDDHTHTVGHGHGHGHGHGHGHGHGHGHGHGHGHGHGHGKHTNKDKNSVKQTTQRTESLASSSEYSTTSTQMQGRTEGPTLTPPRAQPTVTSSGFQDSDFIEDVVATTPPYDTGAHDDLIPDIHVQPDSLSFKLISDFPEATSPKCPGRPWKPASWEDPNTETTEFSDFDLLDALS
uniprot
proteins
function
FUNCTION: Kininogens are inhibitors of thiol proteases. HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; HMW-kininogen inhibits the thrombin- and plasmin-induced aggregation of thrombocytes. LMW-kininogen inhibits the aggregation of thrombocytes. LMW-kininogen is in contrast to HMW-kininogen not involved in blood clotting.; FUNCTION: [Bradykinin]: The active peptide bradykinin is a potent vasodilatator that is released from HMW-kininogen shows a variety of physiological effects: (A) influence in smooth muscle contraction, (B) induction of hypotension, (C) natriuresis and diuresis, (D) decrease in blood glucose level, (E) it is a mediator of inflammation and causes (E1) increase in vascular permeability, (E2) stimulation of nociceptors (4E3) release of other mediators of inflammation (e.g. prostaglandins), (F) it has a cardioprotective effect (directly via bradykinin action, indirectly via endothelium-derived relaxing factor action). {ECO:0000250|UniProtKB:P01042}.
uniprot
proteins
mass_dalton
73102
uniprot
proteins
post_translational_modification
PTM: Bradykinin is released from kininogen by plasma kallikrein.; PTM: Phosphorylated by FAM20C in the extracellular medium. {ECO:0000250|UniProtKB:P01042}.; PTM: [Bradykinin]: Bradykinin is inactivated by ACE, which removes the dipeptide Arg-Phe from its C-terminus. {ECO:0000250|UniProtKB:P01042}.
uniprot
proteins
pubmed
15134344
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16944957
uniprot
proteins
pubmed
17330941
uniprot
proteins
pubmed
20116414
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9199253
uniprot
proteins
sequence_length
661
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space.
uniprot
proteins