Akr1a1
entrez
58810
canonical
uniprot
Q9JII6
canonical
ensembl
ENSMUSG00000028692
resolver
ensp
ENSMUSP00000030455
resolver
enst
ENSMUST00000030455
resolver
genesymbol
Akr1a1
resolver
genesymbol_syn
Akr1a4
resolver
uniprot
Q540D7
resolver
uniprot
Q80XJ7
resolver
uniprot
Q9CQI5
resolver
uniprot
Q9CQT8
resolver
uniprot
Q9CT53
resolver
uniprot
Q9D012
resolver
uniprot
Q9D016
resolver
uniprot
Q9D0I7
resolver
uniprot
Q9D0P3
resolver
uniprot_entry
AK1A1_MOUSE
resolver
uniprot_entry
Q540D7_MOUSE
resolver
uniprot_entry
Q80XJ7_MOUSE
resolver
uniprot_sec
Q9CQI5
resolver
uniprot_sec
Q9CQT8
resolver
uniprot_sec
Q9CT53
resolver
uniprot_sec
Q9D012
resolver
uniprot_sec
Q9D016
resolver
uniprot_sec
Q9D0I7
resolver
uniprot_sec
Q9D0P3
resolver
amino_acid_sequence
MTASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIVPMITVDGKRVPRDAGHPLYPFNDPY
uniprot
proteins
ec_number
1.1.1.19
uniprot
proteins
ec_number
1.1.1.2
uniprot
proteins
ec_number
1.1.1.20
uniprot
proteins
ec_number
1.1.1.372
uniprot
proteins
ec_number
1.1.1.54
uniprot
proteins
ec_number
1.6.-.-
uniprot
proteins
function
FUNCTION: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:15769935, PubMed:20410296, PubMed:22820017). Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde (PubMed:15769935, PubMed:20410296, PubMed:22820017). Plays an important role in ascorbic acid biosynthesis by catalyzing the reduction of D-glucuronic acid and D-glucurono-gamma-lactone (PubMed:15769935, PubMed:20410296, PubMed:22820017). Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes (By similarity). Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic (By similarity). Involved in the detoxification of lipid-derived aldehydes like acrolein (By similarity). Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs (By similarity). Also acts as an inhibitor of protein S-nitrosylation by mediating degradation of S-nitroso-coenzyme A (S-nitroso-CoA), a cofactor required to S-nitrosylate proteins (PubMed:25512491, PubMed:30487609). S-nitroso-CoA reductase activity is involved in reprogramming intermediary metabolism in renal proximal tubules, notably by inhibiting protein S-nitrosylation of isoform 2 of PKM (PKM2) (PubMed:30487609). Also acts as a S-nitroso-glutathione reductase by catalyzing the NADPH-dependent reduction of S-nitrosoglutathione (PubMed:31649033). Displays no reductase activity towards retinoids (By similarity). {ECO:0000250|UniProtKB:P14550, ECO:0000250|UniProtKB:P50578, ECO:0000250|UniProtKB:P51635, ECO:0000269|PubMed:15769935, ECO:0000269|PubMed:20410296, ECO:0000269|PubMed:22820017, ECO:0000269|PubMed:25512491, ECO:0000269|PubMed:30487609, ECO:0000269|PubMed:31649033}.
uniprot
proteins
mass_dalton
36587
uniprot
proteins
protein_family
Aldo/keto reductase family
uniprot
proteins
pubmed
10842086
uniprot
proteins
pubmed
11533224
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15769935
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20410296
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22820017
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
25512491
uniprot
proteins
pubmed
30487609
uniprot
proteins
pubmed
31649033
uniprot
proteins
sequence_length
325
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:15769935}. Apical cell membrane {ECO:0000269|PubMed:15769935}.
uniprot
proteins