Crk
entrez
54245
canonical
uniprot
Q63768
canonical
ensembl
ENSRNOG00000025792
resolver
ensembl
ENSRNOG00055030050
resolver
ensembl
ENSRNOG00060022412
resolver
ensembl
ENSRNOG00065021729
resolver
ensp
ENSRNOP00000106726
resolver
genesymbol
Crk
resolver
genesymbol_syn
Crko
resolver
uniprot_entry
CRK_RAT
resolver
amino_acid_sequence
MAGNFDSEERSSWYWGRLSRQEAVALLQGQRHGVFLVRDSSTSPGDYVLSVSENSRVSHYIINSSGPRPPVPPSPAQPPPGVSPSRLRIGDQEFDSLPALLEFYKIHYLDTTTLIEPVSRSRQGSGVILRQEEAEYVRALFDFNGNDEEDLPFKKGDILRIRDKPEEQWWNAEDSEGKRGMIPVPYVEKYRPASASVSALIGGNQEGSHPQPLGGPEPGPYAQPSVNTPLPNLQNGPIYARVIQKRVPNAYDKTALALEVGELVKVTKINVSGQWEGECNGKRGHFPFTHVRLLDQQNPEEDFS
uniprot
proteins
function
FUNCTION: Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1. {ECO:0000250|UniProtKB:P46108}.; FUNCTION: [Isoform Crk-II]: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4 (By similarity). May regulate the EFNA5-EPHA3 signaling (By similarity). {ECO:0000250|UniProtKB:P46108, ECO:0000250|UniProtKB:Q64010}.
uniprot
proteins
mass_dalton
33845
uniprot
proteins
mutagenesis
MUTAGEN 221; /note="Y->F: No activation of Rac signaling."; /evidence="ECO:0000269|PubMed:12198159
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Tyr-221 upon cell adhesion. Results in the negative regulation of the association with SH2- and SH3-binding partners, possibly by the formation of an intramolecular interaction of phosphorylated Tyr-221 with the SH2 domain. This leads finally to the down-regulation of the Crk signaling pathway (PubMed:12198159). Isoform Crk-II: Phosphorylated by KIT (By similarity). {ECO:0000250|UniProtKB:P46108, ECO:0000269|PubMed:12198159}.; PTM: Proline isomerization at Pro-237 by PPIA acts as a switch between two conformations: an autoinhibitory conformation in the cis form, where the tandem SH3 domains interact intramolecularly, and an activated conformation in the trans form. {ECO:0000250}.
uniprot
proteins
protein_family
CRK family
uniprot
proteins
pubmed
12198159
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8901553
uniprot
proteins
sequence_length
304
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Note=Translocated to the plasma membrane upon cell adhesion.
uniprot
proteins