Hal
entrez
29301
canonical
uniprot
P21213
canonical
ensembl
ENSRNOG00000004502
resolver
ensembl
ENSRNOG00055005880
resolver
ensembl
ENSRNOG00060027612
resolver
ensembl
ENSRNOG00065012257
resolver
ensp
ENSRNOP00000006971
resolver
ensp
ENSRNOP00055007321
resolver
ensp
ENSRNOP00060039850
resolver
ensp
ENSRNOP00065015276
resolver
enst
ENSRNOT00000006971
resolver
enst
ENSRNOT00055009508
resolver
enst
ENSRNOT00060047906
resolver
enst
ENSRNOT00065019927
resolver
genesymbol
Hal
resolver
genesymbol_syn
Huth
resolver
uniprot
Q5EBB8
resolver
uniprot_entry
HUTH_RAT
resolver
uniprot_sec
Q5EBB8
resolver
amino_acid_sequence
MPRYTVHVRGEWLAVPCQDGKLSVGWLGREAVRRYMKNKPDNGGFTSVDEVRFLVRRCKGLGLLDNEDLLEVALEDNEFVEVVIEGDVMSPDFIPSQPEGVFLYSKYREPEKYIALDGDSLSTEDLVNLGKGHYKIKLTSIAEKKVQQSREVIDSIIKERTVVYGITTGFGKFARTVIPANKLQELQVNLVRSHSSGVGKPLSPERCRMLLALRINVLAKGYSGISLETLKQVIEVFNASCLSYVPEKGTVGASGDLAPLSHLALGLIGEGKMWSPKSGWADAKYVLEAHGLKPIVLKPKEGLALINGTQMITSLGCEAVERASAIARQADIVAALTLEVLKGTTKAFDTDIHAVRPHRGQIEVAFRFRSLLDSDHHPSEIAESHRFCDRVQDAYTLRCCPQVHGVVNDTIAFVKDIITTELNSATDNPMVFASRGETISGGNFHGEYPAKALDYLAIGVHELAAISERRIERLCNPSLSELPAFLVAEGGLNSGFMIAHCTAAALVSESKALCHPSSVDSLSTSAATEDHVSMGGWAARKALRVIEHVEQVLAIELLAACQGIEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAPDIEAAHRLLLDQKVWEVAAPYIEKYRMEHIPESRPLSPTAFSLESLRKNSATIPESDDL
uniprot
proteins
ec_number
4.3.1.3
uniprot
proteins
function
FUNCTION: Catalyzes the first reaction in histidine catabolism, the non-oxidative deamination of L-histidine to trans-urocanic. {ECO:0000269|PubMed:7961661, ECO:0000269|PubMed:8486363}.
uniprot
proteins
mass_dalton
72284
uniprot
proteins
mutagenesis
MUTAGEN 223; /note="S->A: 2.4% of activity."; /evidence="ECO:0000269|PubMed:7961661"; MUTAGEN 254; /note="S->A: Complete loss of activity."; /evidence="ECO:0000269|PubMed:7961661"; MUTAGEN 322; /note="R->Q: Reduces protein abundance. Reduces histidine ammonia-lyase activity."; /evidence="ECO:0000269|PubMed:8486363"; MUTAGEN 508; /note="S->A: 75% of activity."; /evidence="ECO:0000269|PubMed:7961661"; MUTAGEN 533; /note="S->A: 16% of activity."; /evidence="ECO:0000269|PubMed:7961661
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.
uniprot
proteins
post_translational_modification
PTM: Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly. {ECO:0000250}.
uniprot
proteins
protein_family
PAL/histidase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2120224
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7961661
uniprot
proteins
pubmed
8486363
uniprot
proteins
sequence_length
657
uniprot
proteins