CSE1L
entrez
1434
canonical
uniprot
P55060
canonical
ensembl
ENSG00000124207
resolver
ensp
ENSP00000262982
resolver
ensp
ENSP00000379495
resolver
ensp
ENSP00000787793
resolver
genesymbol
CSE1L
resolver
genesymbol_syn
CAS
resolver
genesymbol_syn
XPO2
resolver
hgnc
HGNC:2431
resolver
uniprot
A0A384NKW7
resolver
uniprot
A3RLL6
resolver
uniprot
B2R5T4
resolver
uniprot
E1P5Y0
resolver
uniprot
F8W904
resolver
uniprot
O75432
resolver
uniprot
Q32M40
resolver
uniprot
Q9H5B7
resolver
uniprot
Q9NTS0
resolver
uniprot
Q9UP98
resolver
uniprot
Q9UP99
resolver
uniprot
Q9UPA0
resolver
uniprot_entry
A0A384NKW7_HUMAN
resolver
uniprot_entry
XPO2_HUMAN
resolver
uniprot_sec
A3RLL6
resolver
uniprot_sec
B2R5T4
resolver
uniprot_sec
E1P5Y0
resolver
uniprot_sec
F8W904
resolver
uniprot_sec
O75432
resolver
uniprot_sec
Q32M40
resolver
uniprot_sec
Q9H5B7
resolver
uniprot_sec
Q9NTS0
resolver
uniprot_sec
Q9UP98
resolver
uniprot_sec
Q9UP99
resolver
uniprot_sec
Q9UPA0
resolver
amino_acid_sequence
MELSDANLQTLTEYLKKTLDPDPAIRRPAEKFLESVEGNQNYPLLLLTLLEKSQDNVIKVCASVTFKNYIKRNWRIVEDEPNKICEADRVAIKANIVHLMLSSPEQIQKQLSDAISIIGREDFPQKWPDLLTEMVNRFQSGDFHVINGVLRTAHSLFKRYRHEFKSNELWTEIKLVLDAFALPLTNLFKATIELCSTHANDASALRILFSSLILISKLFYSLNFQDLPEFFEDNMETWMNNFHTLLTLDNKLLQTDDEEEAGLLELLKSQICDNAALYAQKYDEEFQRYLPRFVTAIWNLLVTTGQEVKYDLLVSNAIQFLASVCERPHYKNLFEDQNTLTSICEKVIVPNMEFRAADEEAFEDNSEEYIRRDLEGSDIDTRRRAACDLVRGLCKFFEGPVTGIFSGYVNSMLQEYAKNPSVNWKHKDAAIYLVTSLASKAQTQKHGITQANELVNLTEFFVNHILPDLKSANVNEFPVLKADGIKYIMIFRNQVPKEHLLVSIPLLINHLQAESIVVHTYAAHALERLFTMRGPNNATLFTAAEIAPFVEILLTNLFKALTLPGSSENEYIMKAIMRSFSLLQEAIIPYIPTLITQLTQKLLAVSKNPSKPHFNHYMFEAICLSIRITCKANPAAVVNFEEALFLVFTEILQNDVQEFIPYVFQVMSLLLETHKNDIPSSYMALFPHLLQPVLWERTGNIPALVRLLQAFLERGSNTIASAAADKIPGLLGVFQKLIASKANDHQGFYLLNSIIEHMPPESVDQYRKQIFILLFQRLQNSKTTKFIKSFLVFINLYCIKYGALALQEIFDGIQPKMFGMVLEKIIIPEIQKVSGNVEKKICAVGITKLLTECPPMMDTEYTKLWTPLLQSLIGLFELPEDDTIPDEEHFIDIEDTPGYQTAFSQLAFAGKKEHDPVGQMVNNPKIHLAQSLHKLSTACPGRVPSMVSTSLNAEALQYLQGYLQAASVTLL
uniprot
proteins
function
FUNCTION: Export receptor for importin-alpha. Mediates importin-alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:9323134}.
uniprot
proteins
mass_dalton
110417
uniprot
proteins
protein_family
XPO2/CSE1 family
uniprot
proteins
pubmed
10331944
uniprot
proteins
pubmed
11703094
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20933420
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
7479798
uniprot
proteins
pubmed
9323134
uniprot
proteins
pubmed
9786944
uniprot
proteins
sequence_length
971
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9323134}. Nucleus {ECO:0000269|PubMed:9323134}. Note=Shuttles between the nucleus and the cytoplasm. {ECO:0000269|PubMed:9323134}.
uniprot
proteins