Tmem100
entrez
497979
canonical
uniprot
Q569C0
canonical
ensembl
ENSRNOG00000002434
resolver
ensembl
ENSRNOG00055026924
resolver
ensembl
ENSRNOG00060025208
resolver
ensembl
ENSRNOG00065020119
resolver
ensp
ENSRNOP00000003297
resolver
ensp
ENSRNOP00000097274
resolver
ensp
ENSRNOP00000103983
resolver
ensp
ENSRNOP00000110583
resolver
ensp
ENSRNOP00055038120
resolver
ensp
ENSRNOP00055038127
resolver
ensp
ENSRNOP00060036176
resolver
ensp
ENSRNOP00060036207
resolver
ensp
ENSRNOP00065027143
resolver
ensp
ENSRNOP00065027149
resolver
enst
ENSRNOT00000003297
resolver
enst
ENSRNOT00000097540
resolver
enst
ENSRNOT00000128992
resolver
enst
ENSRNOT00000168821
resolver
enst
ENSRNOT00055046475
resolver
enst
ENSRNOT00055046486
resolver
enst
ENSRNOT00060043629
resolver
enst
ENSRNOT00060043659
resolver
enst
ENSRNOT00065033923
resolver
enst
ENSRNOT00065033929
resolver
genesymbol
Tmem100
resolver
uniprot_entry
TM100_RAT
resolver
amino_acid_sequence
MTEEPTKENLGGPKSPTPVTMEKSPKSEVVVTTVPLVSEVQLTAATGGAELSCYRCIIPFAVVVFITGIVVTAVAYSFNSHGSVISILGLVLLSSGLFLLASSALCWKVRQRNKKVKRRESQTALVVNQRSLFA
uniprot
proteins
function
FUNCTION: Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex. {ECO:0000250|UniProtKB:Q9CQG9}.
uniprot
proteins
mass_dalton
14352
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
134
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9CQG9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9CQG9}. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Perikaryon {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Note=Colocalized with HSPA5 in the endoplasmic reticulum (ER). Enriched in ER microsome. Colocalized with BMP4 in neural cell bodies and neural fibers of the enteric nervous system (By similarity). {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 56..76; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 84..104; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins