DACH2
entrez
117154
canonical
uniprot
Q96NX9
canonical
ensembl
ENSG00000126733
resolver
ensp
ENSP00000362217
resolver
ensp
ENSP00000362223
resolver
ensp
ENSP00000420896
resolver
genesymbol
DACH2
resolver
hgnc
HGNC:16814
resolver
uniprot
A8K3I1
resolver
uniprot
B1AJV3
resolver
uniprot
B4DQG3
resolver
uniprot
Q8NAY3
resolver
uniprot
Q8ND17
resolver
uniprot
Q96N55
resolver
uniprot_entry
A8K3I1_HUMAN
resolver
uniprot_entry
DACH2_HUMAN
resolver
uniprot_sec
B1AJV3
resolver
uniprot_sec
B4DQG3
resolver
uniprot_sec
Q8NAY3
resolver
uniprot_sec
Q8ND17
resolver
uniprot_sec
Q96N55
resolver
amino_acid_sequence
MAVSASPVISATSSGAGVPGGLFRAEPLYSTPREPPRLTPNMINSFVVNNHSNSAGGGGRGNTNTNECRMVDMHGMKVASFLMDGQELICLPQVFDLFLKHLVGGLHTVYTKLKRLDISPVVCTVEQVRILRGLGAIQPGVNRCKLITRKDFETLFTDCTNARRKRQMTRKQAVNSSRPGRPPKRSLGVLQENARLLTHAVPGLLSPGLITPTGITAAAMAEAMKLQKMKLMAMNTLQGNGSQNGTESEPDDLNSNTGGSESSWDKDKMQSPFAAPGPQHGIAHAALAGQPGIGGAPTLNPLQQNHLLTNRLDLPFMMMPHPLLPVSLPPASVAMAMNQMNHLNTIANMAAAAQIHSPLSRAGTSVIKERIPESPSPAPSLEENHRPGSQTSSHTSSSVSSSPSQMDHHLERMEEVPVQIPIMKSPLDKIQLTPGQALPAGFPGPFIFADSLSSVETLLTNIQGLLKVALDNARIQEKQIQQEKKELRLELYREREIRENLERQLAVELQSRTTMQKRLKKEKKTKRKLQEALEFESKRREQVEQALKQATTSDSGLRMLKDTGIPDIEIENNGTPHDSAAMQGGNYYCLEMAQQLYSA
uniprot
proteins
function
FUNCTION: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression also seems to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression (By similarity). Probably binds to DNA via its DACHbox-N domain. {ECO:0000250}.
uniprot
proteins
mass_dalton
65323
uniprot
proteins
protein_family
DACH/dachshund family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
17974005
uniprot
proteins
sequence_length
599
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins