Has2
entrez
25694
canonical
uniprot
O35776
canonical
ensembl
ENSRNOG00000004854
resolver
ensembl
ENSRNOG00055021708
resolver
ensembl
ENSRNOG00060003489
resolver
ensembl
ENSRNOG00065015133
resolver
ensp
ENSRNOP00000006517
resolver
ensp
ENSRNOP00055030261
resolver
ensp
ENSRNOP00060004182
resolver
ensp
ENSRNOP00065019609
resolver
enst
ENSRNOT00000006517
resolver
enst
ENSRNOT00055037174
resolver
enst
ENSRNOT00060005727
resolver
enst
ENSRNOT00065025052
resolver
genesymbol
Has2
resolver
uniprot_entry
HYAS2_RAT
resolver
amino_acid_sequence
MHCERFLCVLRIIGTTLFGVSLLLGITAAYIVGYQFIQTDNYYFSFGLYGAFLASHLIIQSLFAFLEHRKMKKSLETPIKLNKTVALCIAAYQEDPDYLRKCLQSVKRLTYPGIKVVMVIDGNSDDDLYMMDIFSEVMGRDKSVTYIWKNNFHERGPGETEESHKESSQHVTQLVLSNKSICIMQKWGGKREVMYTAFRALGRSVDYVQVCDSDTMLDPASSVEMVKVLEEDPMVGGVGGDVQILNKYDSWISFLSSVRYWMAFNIERACQSYFGCVQCISGPLGMYRNSLLHEFVEDWYNQEFMGNQCSFGDDRHLTNRVLSLGYATKYTARSKCLTETPIEYLRWLNQQTRWSKSYFREWLYNAMWFHKHHLWMTYEAVITGFFPFFLIATVIQLFYRGKIWNILLFLLTVQLVGLIKSSFASCLRGNIVMVFMSLYSVLYMSSLLPAKMFAIATINKAGWGTSGRKTIVVNFIGLIPVSVWFTILLGGVIFTIYKESKKPFSESKQTVLIVGTLIYACYWVVLLTLYVVLINKCGRRKKGQQYDMVLDV
uniprot
proteins
ec_number
2.4.1.212
uniprot
proteins
function
FUNCTION: Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation (By similarity). This is one of three isoenzymes responsible for cellular hyaluronan synthesis and it is particularly responsible for the synthesis of high molecular mass hyaluronan (By similarity). {ECO:0000250|UniProtKB:P70312, ECO:0000250|UniProtKB:Q92819}.
uniprot
proteins
mass_dalton
63534
uniprot
proteins
pathway_participation
PATHWAY: Glycan biosynthesis; hyaluronan biosynthesis. {ECO:0000250|UniProtKB:Q92819}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-328 is essential for hyaluronan synthase activity. {ECO:0000250|UniProtKB:Q92819}.; PTM: O-GlcNAcylation at Ser-221 increases the stability of HAS2 and plasma membrane localization. {ECO:0000250|UniProtKB:Q92819}.; PTM: Ubiquitination at Lys-190; this ubiquitination is essential for hyaluronan synthase activity and homo- or heterooligomerization. Can also be poly-ubiquitinated. Deubiquitinated by USP17L22/USP17 and USP4. USP17L22/USP17 efficiently removes 'Lys-63'- and 'Lys-48'-linked polyubiquitin chains, whereas USP4 preferentially removes monoubiquitination and, partially, both 'Lys-63'- and 'Lys-48'-linked polyubiquitin chain. {ECO:0000250|UniProtKB:Q92819}.
uniprot
proteins
protein_family
NodC/HAS family
uniprot
proteins
sequence_length
552
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q92819}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q92819}; Multi-pass membrane protein {ECO:0000255}. Vesicle {ECO:0000250|UniProtKB:Q92819}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q92819}; Multi-pass membrane protein {ECO:0000255}. Lysosome {ECO:0000250|UniProtKB:Q92819}. Note=Travels from endoplasmic reticulum (ER), Golgi to plasma membrane and either back to endosomes and lysosomes, or out into extracellular vesicles. Post-translational modifications control HAS2 trafficking. {ECO:0000250|UniProtKB:Q92819}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 46..66; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 375..395; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 403..423; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 430..450; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 476..496; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 511..531; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins