IL23R
entrez
149233
canonical
uniprot
Q5VWK5
canonical
ensembl
ENSG00000162594
resolver
ensp
ENSP00000321345
resolver
ensp
ENSP00000513153
resolver
ensp
ENSP00000790108
resolver
genesymbol
IL23R
resolver
hgnc
HGNC:19100
resolver
uniprot
C9JGX4
resolver
uniprot
Q4VGP1
resolver
uniprot
Q4VGP2
resolver
uniprot
Q4VGP3
resolver
uniprot
Q4VGP4
resolver
uniprot
Q4VGP5
resolver
uniprot
Q4VGP6
resolver
uniprot
Q5VWK7
resolver
uniprot
Q8IW84
resolver
uniprot
Q8NFQ9
resolver
uniprot
Q96AS1
resolver
uniprot_entry
IL23R_HUMAN
resolver
uniprot_sec
C9JGX4
resolver
uniprot_sec
Q4VGP1
resolver
uniprot_sec
Q4VGP2
resolver
uniprot_sec
Q4VGP3
resolver
uniprot_sec
Q4VGP4
resolver
uniprot_sec
Q4VGP5
resolver
uniprot_sec
Q4VGP6
resolver
uniprot_sec
Q5VWK7
resolver
uniprot_sec
Q8IW84
resolver
uniprot_sec
Q8NFQ9
resolver
uniprot_sec
Q96AS1
resolver
amino_acid_sequence
MNQVTIQWDAVIALYILFSWCHGGITNINCSGHIWVEPATIFKMGMNISIYCQAAIKNCQPRKLHFYKNGIKERFQITRINKTTARLWYKNFLEPHASMYCTAECPKHFQETLICGKDISSGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYIDTKYVVHVKSLETEEEQQYLTSSYINISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDIVIPSAAVISRAETINATVPKTIIYWDSQTTIEKVSCEMRYKATTNQTWNVKEFDTNFTYVQQSEFYLEPNIKYVFQVRCQETGKRYWQPWSSLFFHKTPETVPQVTSKAFQHDTWNSGLTVASISTGHLTSDNRGDIGLLLGMIVFAVMLSILSLIGIFNRSFRTGIKRRILLLIPKWLYEDIPNMKNSNVVKMLQENSELMNNNSSEQVLYVDPMITEIKEIFIPEHKPTDYKKENTGPLETRDYPQNSLFDNTTVVYIPDLNTGYKPQISNFLPEGSHLSNNNEITSLTLKPPVDSLDSGNNPRLQKHPNFAFSVSSVNSLSNTIFLGELSLILNQGECSSPDIQNSVEEETTMLLENDSPSETIPEQTLLPDEFVSCLGIVNEELPSINTYFPQNILESHFNRISLLEK
uniprot
proteins
disease_involvement
DISEASE: Inflammatory bowel disease 17 (IBD17) [MIM:612261]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO:0000269|PubMed:17068223, ECO:0000269|PubMed:17804789}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. {ECO:0000269|PubMed:12023369}.
uniprot
proteins
mass_dalton
71722
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in response to IL23. {ECO:0000269|PubMed:12023369}.
uniprot
proteins
protein_family
Type 2 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
12023369
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16372191
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17068223
uniprot
proteins
pubmed
17587057
uniprot
proteins
pubmed
17804789
uniprot
proteins
pubmed
18800148
uniprot
proteins
pubmed
21053369
uniprot
proteins
sequence_length
629
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12023369}; Single-pass type I membrane protein {ECO:0000269|PubMed:12023369}.
uniprot
proteins
transmembrane_region
TRANSMEM 356..376; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins