Soat1
entrez
81782
canonical
uniprot
O70536
canonical
ensembl
ENSRNOG00000004111
resolver
ensp
ENSRNOP00000005677
resolver
genesymbol
Soat1
resolver
genesymbol_syn
Acact
resolver
genesymbol_syn
Acat
resolver
uniprot_entry
SOAT1_RAT
resolver
amino_acid_sequence
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF
uniprot
proteins
ec_number
2.3.1.26
uniprot
proteins
function
FUNCTION: Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. Preferentially utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) as substrate: shows a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions. {ECO:0000250|UniProtKB:P35610}.
uniprot
proteins
mass_dalton
64146
uniprot
proteins
protein_family
Membrane-bound acyltransferase family
uniprot
proteins
protein_family
Sterol o-acyltransferase subfamily
uniprot
proteins
pubmed
9555010
uniprot
proteins
sequence_length
545
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P35610}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P35610}.
uniprot
proteins
transmembrane_region
TRANSMEM 134..155; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P35610"; TRANSMEM 176..201; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P35610"; TRANSMEM 214..239; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P35610"; TRANSMEM 248..271; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P35610"; TRANSMEM 315..347; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P35610"; TRANSMEM 365..390; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P35610"; TRANSMEM 439..463; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P35610"; TRANSMEM 470..485; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P35610"; TRANSMEM 492..523; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:P35610
uniprot
proteins