Poglut1
entrez
224143
canonical
uniprot
Q8BYB9
canonical
ensembl
ENSMUSG00000034064
resolver
ensp
ENSMUSP00000038166
resolver
enst
ENSMUST00000036210
resolver
genesymbol
Poglut1
resolver
genesymbol_syn
Clp46
resolver
genesymbol_syn
Ktelc1
resolver
uniprot
Q8BLG5
resolver
uniprot
Q8BV60
resolver
uniprot
Q8R0H7
resolver
uniprot_entry
PGLT1_MOUSE
resolver
uniprot_entry
Q8BLG5_MOUSE
resolver
uniprot_entry
Q8BV60_MOUSE
resolver
uniprot_sec
Q8R0H7
resolver
amino_acid_sequence
MERRAGSRLRAWMLLLLLCPVQGRQKDSGSKWKVFLDQINRALENYEPCSSQNCSCYHGVIEEDLTPFRGGISRKMMAEVVRRKLGTHYQIIKNRLFREDDCMFPSRCSGVEHFILEVIHRLPDMEMVINVRDYPQVPKWMEPTIPVFSFSKTSEYHDIMYPAWTFWEGGPAVWPLYPTGLGRWDLFREDLLRSAAQWPWEKKNSTAYFRGSRTSPERDPLILLSRKNPKLVDAEYTKNQAWKSMKDTLGKPAAKDVHLIDHCKYRYLFNFRGVAASFRFKHLFLCGSLVFHVGDEWVEFFYPQLKPWVHYIPVKTDLSNVQELLQFVKANDDIAQEIAKRGSQFIINHLQMDDITCYWENLLTDYSKFLSYNVTRRKDYYQIVPRRLKTEL
uniprot
proteins
ec_number
2.4.1.376
uniprot
proteins
ec_number
2.4.2.63
uniprot
proteins
function
FUNCTION: Dual specificity glycosyltransferase that catalyzes the transfer of glucose and xylose from UDP-glucose and UDP-xylose, respectively, to a serine residue found in the consensus sequence of C-X-S-X-P-C (PubMed:21949356, PubMed:26496195). Specifically targets extracellular EGF repeats of protein such as CRB2, F7, F9 and NOTCH2 (PubMed:21949356, PubMed:26496195). Acts as a positive regulator of Notch signaling by mediating O-glucosylation of Notch, leading to regulate muscle development (By similarity). Notch glucosylation does not affect Notch ligand binding (By similarity). Required during early development to promote gastrulation: acts by mediating O-glucosylation of CRB2, which is required for CRB2 localization to the cell membrane (PubMed:26496195). {ECO:0000250|UniProtKB:Q8NBL1, ECO:0000269|PubMed:21949356, ECO:0000269|PubMed:26496195}.
uniprot
proteins
mass_dalton
46379
uniprot
proteins
mutagenesis
MUTAGEN 389..392; /note="Missing: Significantly more secreted than wild-type."; /evidence="ECO:0000269|PubMed:21949356
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:21949356, ECO:0000269|PubMed:26496195}.
uniprot
proteins
protein_family
Glycosyltransferase 90 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21490058
uniprot
proteins
pubmed
21949356
uniprot
proteins
pubmed
26496195
uniprot
proteins
sequence_length
392
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:Q8NBL1}.
uniprot
proteins