Tgfbr1
entrez
21812
canonical
uniprot
Q64729
canonical
ensembl
ENSMUSG00000007613
resolver
ensp
ENSMUSP00000007757
resolver
ensp
ENSMUSP00000048501
resolver
ensp
ENSMUSP00000103353
resolver
ensp
ENSMUSP00000123761
resolver
ensp
ENSMUSP00000226979
resolver
enst
ENSMUST00000107725
resolver
enst
ENSMUST00000126171
resolver
genesymbol
Tgfbr1
resolver
uniprot
A2AJN0
resolver
uniprot
E9Q418
resolver
uniprot
F6U9M8
resolver
uniprot
Q4FJL1
resolver
uniprot
Q9D5H8
resolver
uniprot_entry
E9Q418_MOUSE
resolver
uniprot_entry
F6U9M8_MOUSE
resolver
uniprot_entry
Q4FJL1_MOUSE
resolver
uniprot_entry
Q9D5H8_MOUSE
resolver
uniprot_entry
TGFR1_MOUSE
resolver
uniprot_sec
A2AJN0
resolver
activity_regulation
ACTIVITY REGULATION: Kept in an inactive conformation by FKBP1A preventing receptor activation in absence of ligand. CD109 is another inhibitor of the receptor (By similarity). {ECO:0000250|UniProtKB:P36897}.
uniprot
proteins
amino_acid_sequence
MEAAAAAPRRPQLLIVLVAAATLLPGAKALQCFCHLCTKDNFTCETDGLCFVSVTETTDKVIHNSMCIAEIDLIPRDRPFVCAPSSKTGAVTTTYCCNQDHCNKIELPTTGPFSEKQSAGLGPVELAAVIAGPVCFVCIALMLMVYICHNRTVIHHRVPNEEDPSLDRPFISEGTTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFGEVWRGKWRGEEVAVKIFSSREERSWFREAEIYQTVMLRHENILGFIAADNKDNGTWTQLWLVSDYHEHGSLFDYLNRYTVTVEGMIKLALSTASGLAHLHMEIVGTQGKPAIAHRDLKSKNILVKKNGTCCIADLGLAVRHDSATDTIDIAPNHRVGTKRYMAPEVLDDSINMKHFESFKRADIYAMGLVFWEIARRCSIGGIHEDYQLPYYDLVPSDPSVEEMRKVVCEQKLRPNIPNRWQSCEALRVMAKIMRECWYANGAARLTALRIKKTLSQLSQQEGIKM
uniprot
proteins
ec_number
2.7.11.30
uniprot
proteins
function
FUNCTION: Transmembrane serine/threonine kinase forming with the TGF-beta type II serine/threonine kinase receptor, TGFBR2, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFBR1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. For instance, TGFBR1 induces TRAF6 autoubiquitination which in turn results in MAP3K7 ubiquitination and activation to trigger apoptosis. Also regulates epithelial to mesenchymal transition through a SMAD-independent signaling pathway through PARD6A phosphorylation and activation (By similarity). {ECO:0000250|UniProtKB:P36897}.
uniprot
proteins
mass_dalton
56179
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at basal levels in the absence of ligand. Activated upon phosphorylation by TGFBR2, mainly in the GS domain. Phosphorylation in the GS domain abrogates FKBP1A-binding (By similarity). {ECO:0000250|UniProtKB:P36897}.; PTM: N-Glycosylated. {ECO:0000250|UniProtKB:P36897}.; PTM: Ubiquitinated; undergoes ubiquitination catalyzed by several E3 ubiquitin ligases including SMURF1, SMURF2 and NEDD4L2. Results in the proteasomal and/or lysosomal degradation of the receptor thereby negatively regulating its activity. Deubiquitinated by USP15, leading to stabilization of the protein and enhanced TGF-beta signal. Its ubiquitination and proteasome-mediated degradation is negatively regulated by SDCBP. Ubiquitinated by BFAR via'Lys-63'-linked ubiquitination at Lys-268, leading to TGF-beta signaling activation (By similarity). {ECO:0000250|UniProtKB:P36897}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
TGFB receptor subfamily
uniprot
proteins
protein_family
TKL Ser/Thr protein kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
8117261
uniprot
proteins
pubmed
8117262
uniprot
proteins
sequence_length
503
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P36897}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P36897}. Cell junction, tight junction {ECO:0000250|UniProtKB:P36897}. Membrane raft {ECO:0000250|UniProtKB:P36897}. Cell surface {ECO:0000250|UniProtKB:P36897}.
uniprot
proteins
transmembrane_region
TRANSMEM 127..147; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins