GORASP1
entrez
64689
canonical
uniprot
Q9BQQ3
canonical
ensembl
ENSG00000114745
resolver
ensp
ENSP00000313869
resolver
ensp
ENSP00000392993
resolver
ensp
ENSP00000395709
resolver
ensp
ENSP00000419123
resolver
ensp
ENSP00000511895
resolver
ensp
ENSP00000511911
resolver
ensp
ENSP00000552056
resolver
ensp
ENSP00000692275
resolver
ensp
ENSP00000692277
resolver
enst
ENST00000422110
resolver
enst
ENST00000479927
resolver
enst
ENST00000695414
resolver
enst
ENST00000695430
resolver
genesymbol
GORASP1
resolver
genesymbol_syn
GOLPH5
resolver
genesymbol_syn
GRASP65
resolver
hgnc
HGNC:16769
resolver
uniprot
A0A8Q3SHU6
resolver
uniprot
A0A8Q3WL08
resolver
uniprot
B3KPY8
resolver
uniprot
B3KWC8
resolver
uniprot
B4E1H8
resolver
uniprot
F6S8C4
resolver
uniprot
F6WXU4
resolver
uniprot
Q3SYG7
resolver
uniprot
Q8N272
resolver
uniprot
Q96H42
resolver
uniprot_entry
A0A8Q3SHU6_HUMAN
resolver
uniprot_entry
A0A8Q3WL08_HUMAN
resolver
uniprot_entry
B3KPY8_HUMAN
resolver
uniprot_entry
B4E1H8_HUMAN
resolver
uniprot_entry
F6S8C4_HUMAN
resolver
uniprot_entry
F6WXU4_HUMAN
resolver
uniprot_entry
GORS1_HUMAN
resolver
uniprot_sec
B3KWC8
resolver
uniprot_sec
Q3SYG7
resolver
uniprot_sec
Q8N272
resolver
uniprot_sec
Q96H42
resolver
amino_acid_sequence
MGLGVSAEQPAGGAEGFHLHGVQENSPAQQAGLEPYFDFIITIGHSRLNKENDTLKALLKANVEKPVKLEVFNMKTMRVREVEVVPSNMWGGQGLLGASVRFCSFRRASEQVWHVLDVEPSSPAALAGLRPYTDYVVGSDQILQESEDFFTLIESHEGKPLKLMVYNSKSDSCREVTVTPNAAWGGEGSLGCGIGYGYLHRIPTQPPSYHKKPPGTPPPSALPLGAPPPDALPPGPTPEDSPSLETGSRQSDYMEALLQAPGSSMEDPLPGPGSPSHSAPDPDGLPHFMETPLQPPPPVQRVMDPGFLDVSGISLLDNSNASVWPSLPSSTELTTTAVSTSGPEDICSSSSSHERGGEATWSGSEFEVSFLDSPGAQAQADHLPQLTLPDSLTSAASPEDGLSAELLEAQAEEEPASTEGLDTGTEAEGLDSQAQISTTE
uniprot
proteins
function
FUNCTION: Key structural protein of the Golgi apparatus (PubMed:33301566). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:33301566). Acting in concert with GORASP2/GRASP55, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:33301566). However, other studies suggest that GORASP1 plays an important role in assembly and membrane stacking of the cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis (By similarity). Caspase-mediated cleavage of GORASP1 is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936). {ECO:0000250|UniProtKB:O35254, ECO:0000269|PubMed:16489344, ECO:0000269|PubMed:21884936, ECO:0000269|PubMed:33301566}.
uniprot
proteins
mass_dalton
46482
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CDC2/B1 and PLK kinases during mitosis. Phosphorylation cycle correlates with the cisternal stacking cycle. Phosphorylation of the homodimer prevents the association of dimers into higher-order oligomers, leading to cisternal unstacking. {ECO:0000250|UniProtKB:O35254}.; PTM: Target for caspase-3 cleavage during apoptosis. The cleavage contributes to Golgi fragmentation and occurs very early in the execution phase of apoptosis. {ECO:0000250|UniProtKB:O35254}.; PTM: Myristoylated. {ECO:0000250|UniProtKB:O35254}.
uniprot
proteins
protein_family
GORASP family
uniprot
proteins
pubmed
11781572
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16489344
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21884936
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26363069
uniprot
proteins
pubmed
33301566
uniprot
proteins
sequence_length
440
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane {ECO:0000269|PubMed:11781572}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:11781572}.
uniprot
proteins