Arap1
entrez
69710
canonical
uniprot
Q4LDD4
canonical
ensembl
ENSMUSG00000032812
resolver
ensp
ENSMUSP00000081957
resolver
ensp
ENSMUSP00000081958
resolver
ensp
ENSMUSP00000095844
resolver
ensp
ENSMUSP00000102624
resolver
enst
ENSMUST00000098243
resolver
genesymbol
Arap1
resolver
genesymbol_syn
Centd2
resolver
genesymbol_syn
Kiaa0782
resolver
uniprot
B2RUJ3
resolver
uniprot
E9PUB0
resolver
uniprot
Q3UDD2
resolver
uniprot
Q3US99
resolver
uniprot
Q58ET6
resolver
uniprot
Q6PEQ9
resolver
uniprot
Q6ZQ48
resolver
uniprot_entry
ARAP1_MOUSE
resolver
uniprot_entry
E9PUB0_MOUSE
resolver
uniprot_sec
B2RUJ3
resolver
uniprot_sec
Q3UDD2
resolver
uniprot_sec
Q3US99
resolver
uniprot_sec
Q58ET6
resolver
uniprot_sec
Q6PEQ9
resolver
uniprot_sec
Q6ZQ48
resolver
amino_acid_sequence
MAEGYDAALSVAEWLRALHLEQYTALFEQHGLVWATECQGLSDAGLLDMGMHLPGHRRRILAGLHRAHAPPVPLPRPAPRPVPMKRHIFRSPPVPVTPPEPPPTAGEDEGLPAAPPIPPRRSCLPPACFTPTSTAAPDPVLPPLPAKRHLVEPSVPPVPPRTGPPYPQASLLAKEELLLPSVSPRSQPEPAETPSTLLPAFPQGPLQPPSPPPCPPVIPPKPPRLLPEFDDSDYDDVPEEGPGAPASVMTKEEPLPSRVPRAVRVASLLSEGEELSGDDSEDDDDHAYEGIPNGGWPTSGLNPPLRSLIPDLPLHPMDELPGGPTPITPVIKAGWLDKNPPQGSYIYQKRWVRLDADYLRYFDSNKDAYSKRFVPVACICRVAPIGDQKFEVITNNRTFAFRAESDVERNEWMQALQQAVVEHRARFRLSSASVLGVRGSEQPDRAGSLELRGFKNKLYVAVTGDKVQLYKNLEEFHLGIGITFIDMNVGNVKEVDRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALSTSEVAERIWAAAPNRFCADCGAAQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKVWTEALIQLFLHLGNGPGNHFWAANVPPSEALEPSSSPGARRYHLEAKYREGKYRRYHPLFGNQEELDKALCAAVTTTDLAETQALLGCGAGVSCFSGDPAAPTPLALAEQAGQTLQMEFLRNNQSTEVPRLDSVKPLEKHYSVTLPTVSHSGFLYKTASAGKPLQDRRAREEFSRRWCVLSDGVLSYYENERAVTPNGEIRASEIVCLAVSPLDTHGFEHTFEVYTEGERLYLFGLENAELAHEWVKCIAKAFVPPLAEDLLARDFERLGRLPCKAGLSLQQAQEGWFALTGSELRAVFPEGPWEEPLQLRKLQELSIQGDSENQVLVLVERRRTLYIQGERRLDFMAWLGVIQKAAASLGDTLSEQQLGDSDIPVIVYRCVDYITQCGLTSEGIYRKCGQTSKTQRLLDSLRQDARSVHLKEGEQHVDDVSSALKRFLRDLPDGLFTRAQRLAWLEASEIEDEEEKISRYRELLVHLPPVNRATVKALISHLYCVQCFSDTNQMNTHNLAIVFGPTLFQTDGQDYKAGKVVEDLINHYVVVFSVDEEELRKQREEVTAIVKMRVAGTASGTQHAGDFICTVYLEEKKVETEQHVKIPASMTAEELTLEILDRRNVSIREKDYWTCFEVNEKEEAERPLHFAEKVLPIVHGLGIDSHLVVKKYQSMEAMLLYLASRVGDTKHGMMKFREDRSLLGLGLPSGGFHDRYFILNSSCLRLYKEVRSQRPWSGAPETSHRPEKEWPVKSLKVYLGVKKKLRPPTCWGFTVVHETEKHEKQQWYLCCDTQMELREWFATFLSVQHDGLVWPSEPSRVSRAVPEVRMGSVSLIPLRGSENEMRRSVAAFTADPLSLLRHV
uniprot
proteins
function
FUNCTION: Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members (By similarity). Activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding and, to a lesser extent, by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) binding (By similarity). Has a preference for ARF1 and ARF5 (By similarity). Positively regulates the ring size of circular dorsal ruffles and promotes macropinocytosis (By similarity). Acts as a bridging factor in osteoclasts to control actin and membrane dynamics (PubMed:30240610). Regulates the condensing of osteoclast podosomes into sealing zones which segregate the bone-facing membrane from other membrane domains and are required for osteoclast resorption activity (PubMed:30240610). Also regulates recruitment of the AP-3 complex to endosomal membranes and trafficking of lysosomal membrane proteins to the ruffled membrane border of osteoclasts to modulate bone resorption (PubMed:30240610). Regulates the endocytic trafficking of EGFR (By similarity). Regulates the incorporation of CD63 and CD9 into multivesicular bodies (By similarity). Required in the retinal pigment epithelium (RPE) for photoreceptor survival due to its role in promoting RPE phagocytosis (PubMed:28324111, PubMed:35758026). {ECO:0000250|UniProtKB:Q96P48, ECO:0000269|PubMed:28324111, ECO:0000269|PubMed:30240610, ECO:0000269|PubMed:35758026}.
uniprot
proteins
mass_dalton
162276
uniprot
proteins
mutagenesis
MUTAGEN 87; /note="H->A: Does not significantly affect interaction with SH3KBP1."; /evidence="ECO:0000269|PubMed:29589748"; MUTAGEN 87; /note="H->P: Significantly reduces interaction with SH3KBP1."; /evidence="ECO:0000269|PubMed:29589748"; MUTAGEN 90; /note="R->E: Significantly reduces interaction with SH3KBP1."; /evidence="ECO:0000269|PubMed:29589748"; MUTAGEN 90; /note="R->H,K: Does not significantly affect interaction with SH3KBP1."; /evidence="ECO:0000269|PubMed:29589748
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PTK6 following EGF stimulation which enhances EGFR signaling by delaying EGFR down-regulation; the interaction is mediated by the SH2 domain of PTK6. Phosphorylation promotes association with the Golgi apparatus and endosomes. {ECO:0000250|UniProtKB:Q96P48}.
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28324111
uniprot
proteins
pubmed
29589748
uniprot
proteins
pubmed
30240610
uniprot
proteins
pubmed
35758026
uniprot
proteins
sequence_length
1452
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96P48}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q96P48}. Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:Q96P48}. Cell membrane {ECO:0000250|UniProtKB:Q96P48}; Peripheral membrane protein {ECO:0000305}. Endosome, multivesicular body {ECO:0000250|UniProtKB:Q96P48}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q96P48}. Cell projection, podosome {ECO:0000269|PubMed:30240610}. Early endosome {ECO:0000269|PubMed:30240610}. Note=Associated with Golgi stacks in resting cells (By similarity). Throughout the cytoplasm and in surface protrusions in cells that are in the process of attaching to a surface and spreading (By similarity). Localizes to actin-rich podosomes, sealing zones and early endosomes in osteoclasts (PubMed:30240610). {ECO:0000250|UniProtKB:Q96P48, ECO:0000269|PubMed:30240610}.
uniprot
proteins