SERPINF2
entrez
5345
canonical
uniprot
P08697
canonical
ensembl
ENSG00000167711
resolver
ensembl
ENSG00000276838
resolver
ensp
ENSP00000371493
resolver
ensp
ENSP00000402286
resolver
ensp
ENSP00000403877
resolver
ensp
ENSP00000479005
resolver
ensp
ENSP00000481874
resolver
ensp
ENSP00000553674
resolver
ensp
ENSP00000553695
resolver
enst
ENST00000618883
resolver
enst
ENST00000622842
resolver
genesymbol
SERPINF2
resolver
genesymbol_syn
AAP
resolver
genesymbol_syn
PLI
resolver
hgnc
HGNC:9075
resolver
uniprot
B4E1B7
resolver
uniprot
Q8N5U7
resolver
uniprot
Q9UCG2
resolver
uniprot
Q9UCG3
resolver
uniprot_entry
A2AP_HUMAN
resolver
uniprot_sec
B4E1B7
resolver
uniprot_sec
Q8N5U7
resolver
uniprot_sec
Q9UCG2
resolver
uniprot_sec
Q9UCG3
resolver
amino_acid_sequence
MALLWGLLVLSWSCLQGPCSVFSPVSAMEPLGRQLTSGPNQEQVSPLTLLKLGNQEPGGQTALKSPPGVCSRDPTPEQTHRLARAMMAFTADLFSLVAQTSTCPNLILSPLSVALALSHLALGAQNHTLQRLQQVLHAGSGPCLPHLLSRLCQDLGPGAFRLAARMYLQKGFPIKEDFLEQSEQLFGAKPVSLTGKQEDDLANINQWVKEATEGKIQEFLSGLPEDTVLLLLNAIHFQGFWRNKFDPSLTQRDSFHLDEQFTVPVEMMQARTYPLRWFLLEQPEIQVAHFPFKNNMSFVVLVPTHFEWNVSQVLANLSWDTLHPPLVWERPTKVRLPKLYLKHQMDLVATLSQLGLQELFQAPDLRGISEQSLVVSGVQHQSTLELSEVGVEAAAATSIAMSRMSLSSFSVNRPFLFFIFEDTTGLPLFVGSVRNPNPSAPRELKEQQDSPGNKDFLQSLKGFPRGDKLFGPDLKLVPPMEEDYPQFGSPK
uniprot
proteins
disease_involvement
DISEASE: Alpha-2-plasmin inhibitor deficiency (APLID) [MIM:262850]: An autosomal recessive disorder resulting in severe hemorrhagic diathesis. {ECO:0000269|PubMed:10583218, ECO:0000269|PubMed:2572590}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Serine protease inhibitor. The major targets of this inhibitor are plasmin and trypsin, but it also inactivates matriptase-3/TMPRSS7 and chymotrypsin. {ECO:0000269|PubMed:15853774}.
uniprot
proteins
mass_dalton
54566
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved at Pro-39 by both the prolyl endopeptidase FAP form and antiplasmin-cleaving enzyme FAP soluble form to generate mature alpha-2-antiplasmin. {ECO:0000269|PubMed:14751930, ECO:0000269|PubMed:16223769}.
uniprot
proteins
protein_family
Serpin family
uniprot
proteins
pubmed
10583218
uniprot
proteins
pubmed
1385210
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14751930
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15853774
uniprot
proteins
pubmed
16223769
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
21075
uniprot
proteins
pubmed
2433286
uniprot
proteins
pubmed
2434496
uniprot
proteins
pubmed
2440681
uniprot
proteins
pubmed
2456616
uniprot
proteins
pubmed
2572590
uniprot
proteins
pubmed
2830248
uniprot
proteins
pubmed
3166140
uniprot
proteins
pubmed
3818581
uniprot
proteins
pubmed
8484741
uniprot
proteins
pubmed
9169621
uniprot
proteins
sequence_length
491
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins