Pofut2
entrez
80294
canonical
uniprot
Q8VHI3
canonical
ensembl
ENSMUSG00000020260
resolver
ensp
ENSMUSP00000020493
resolver
enst
ENSMUST00000020493
resolver
genesymbol
Pofut2
resolver
uniprot
B2RV73
resolver
uniprot
Q8VEM2
resolver
uniprot
Q9CV66
resolver
uniprot_entry
B2RV73_MOUSE
resolver
uniprot_entry
OFUT2_MOUSE
resolver
uniprot_sec
Q8VEM2
resolver
uniprot_sec
Q9CV66
resolver
amino_acid_sequence
MAALSVVCLLLAAASWRPVSASGEEFWPGQSAADILSGAASRRRYLLYDVNPPEGFNLRRDVYIRVASLLKTLLKTEEWVLVLPPWGRLYHWQSPDIHQVRIPWSEFFDLPSLNKNIPVIEYEQFIAESGGPFIDQVYVLQGYAEGWKEGTWEEKVDARPCIDPLLYSQDKHEYYRGWFWGYEETRGLNVSCLSVQGSASIVAPVLLKNTSARSVMLDRAENLLHDHYGGREYWDTRRSMVFAKHLRAVGDEFRSQHLNSTDAADKMAPEEDWTKMKVKLGSALGGPYLGVHLRRKDFIWGHREDVPSLEGAVKKIRSLMKTHQLDKVFVATDAIRKEQEELRKLLPEMVRFEPTWEELELYKDGGVAIIDQWICAHARFFIGTSVSTFSFRIHEEREILGLDPKTTYNRFCGDQEKACEQPTHWKIAY
uniprot
proteins
ec_number
2.4.1.221
uniprot
proteins
function
FUNCTION: GDP-fucose protein O-fucosyltransferase involved in one of the two pathways responsible for protein O-linked fucosylation, a unique post-translational modification of cysteine-knotted proteins that regulates various biological functions. This pathway targets proteins with Thrombospondin type-1 (TSP1) repeats (TSR) in the endoplasmic reticulum. Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively (PubMed:20637190). O-fucosylates members of several protein families including the ADAMTS, the thrombospondin (TSP) and spondin families (PubMed:20637190). Required for the proper secretion of ADAMTS family members such as ADAMTSL1 and ADAMTS13 (By similarity). The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm (PubMed:20637190). {ECO:0000250|UniProtKB:Q9Y2G5, ECO:0000269|PubMed:20637190}.
uniprot
proteins
mass_dalton
49429
uniprot
proteins
mutagenesis
MUTAGEN 396; /note="E->A: Abolishes in vitro enzyme activity."; /evidence="ECO:0000269|PubMed:20637190
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:20637190}.
uniprot
proteins
protein_family
Glycosyltransferase 68 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20637190
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
429
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9Y2G5}. Golgi apparatus {ECO:0000250|UniProtKB:Q9Y2G5}. Note=Mainly located in the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q9Y2G5}.
uniprot
proteins