Arid4b
entrez
94246
canonical
uniprot
A2CG63
canonical
ensembl
ENSMUSG00000039219
resolver
ensp
ENSMUSP00000043889
resolver
ensp
ENSMUSP00000106163
resolver
ensp
ENSMUSP00000217164
resolver
ensp
ENSMUSP00000217169
resolver
genesymbol
Arid4b
resolver
genesymbol_syn
Sap180
resolver
uniprot
A2CG61
resolver
uniprot
A2CG62
resolver
uniprot
A2CG64
resolver
uniprot
B2RQ67
resolver
uniprot
Q8BMI8
resolver
uniprot
Q8BYA5
resolver
uniprot_entry
ARI4B_MOUSE
resolver
uniprot_sec
A2CG61
resolver
uniprot_sec
A2CG62
resolver
uniprot_sec
A2CG64
resolver
uniprot_sec
B2RQ67
resolver
uniprot_sec
Q8BMI8
resolver
uniprot_sec
Q8BYA5
resolver
amino_acid_sequence
MKALDEPPYLTVGTDVSAKYRGAFCEAKIKTAKRLVKVKVTFRHDSSTVEVQDDHIKGPLKVGAIVEVKNLDGAYQEAVINKLTDASWYTVVFDDGDEKTLRRSSLCLKGERHFAESETLDQLPLTNPEHFGTPVIGKKTNRGRRSNHIPEEESSSSSSDDDEEERKQTDELLGKVVCVDYVSLEKKKAMWFPALVVCPDCSDEIAVKKDNILVRSFKDGKFTSVPRKDVHEITSDTVPKPDAVLKQAFDQALEFHKSRAIPANWKTELKEDSSSSEAEEEEEEEDDEKEKEDNSSEEEEEIEPFPEERENFLQQLYKFMEDRGTPINKRPVLGYRNLNLFKLFRLVHKLGGFDNIESGAVWKQVYQDLGIPVLNSAAGYNVKCAYKKYLYGFEEYCRSANIDFQMALPEKVLNKPCKDCENKEVKVKEESETEIKEVNVEDSKNVMPKEETPAEDESERKENIKPSLGSKKSLLECIPAQSDEEKEAHITKLEENENLEDKDGGRARTEEAFSTEVDGEEEQARSGDETNKEEDEDDEEIEEEEEEDEEEDEDEDDDDNNEEEEFECYPPGMKVQVRYGRGKNQKMYEASIKDSDVEGGEALYLVHYCGWNVRYDEWIKADKIVRPADKNVPKIKHRKKIKNKLDKEKDRDEKYSPKNCKLRRLSKSPFQSNPSPEMVSKLDLADAKNSDTAHIKSIEITSILNGLQASESSAEDSEQEDERCTQDVDNIGKDESKVEHSTHSRNELISKEEQSSPSLLEENKVHTDLVIAKTVSKSPERLRKDMEAISEDTDFEEEDEITKKRKDVKKDTTDKALKPQTKRGKRRYCSADECLQTGSPGKKEDRTKSKEPLCTENSSNSSSDEDEEEKSKAKMTPTKKYNGLEEKRKSLRTTSFYSGFSEVAEKRIKLLNNSDERLQNNRAKDRKDVWSSIQGQWPKKTLKELFSDSDTEAAASPPHPAPDEGAVEESLQTVAEEESCSPIMELEKPLPASVDNKPIEEKPLEVSDRKTEFPSSGSNSVLNTPPTTPESPSSVTITEASQQQSSVTVSVPLPPNQEEVRSIKSETDSTIEVDSVVGELQDLQSEGNSSPAGFDASVSSSSSNQPEPDNPEKACTGQKRVKDTQGVGSSSKKQKRSHKATVVNNKKKGKGTNSSDSEELSAGESVTKTQTIKSVPTGMKTHNSKSPARVQSPGKGGRNGDKDPDLKEPSNRLPKVYKWSFQTSDLENMTSAERISILQEKLQEIRKHYLSLKSEVASIDRRRKRLKKKERESAATSSSSSSPSSSSITAAVMLTLAEPSMSSASQNGMSVECR
uniprot
proteins
function
FUNCTION: Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes (By similarity). Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A (PubMed:17043311). Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier (PubMed:23487765). Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor (PubMed:18728284). {ECO:0000250|UniProtKB:Q4LE39, ECO:0000269|PubMed:17043311, ECO:0000269|PubMed:18728284, ECO:0000269|PubMed:23487765}.
uniprot
proteins
mass_dalton
147643
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17043311
uniprot
proteins
pubmed
18728284
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23487765
uniprot
proteins
sequence_length
1314
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00355}.
uniprot
proteins