Cbll1
entrez
104836
canonical
uniprot
Q9JIY2
canonical
ensembl
ENSMUSG00000020659
resolver
ensp
ENSMUSP00000063266
resolver
ensp
ENSMUSP00000099038
resolver
ensp
ENSMUSP00000139809
resolver
ensp
ENSMUSP00000141007
resolver
enst
ENSMUST00000064240
resolver
genesymbol
Cbll1
resolver
genesymbol_syn
Hakai
resolver
uniprot
A0A1X7SB71
resolver
uniprot
Q3TMC0
resolver
uniprot
Q8C7W5
resolver
uniprot
Q8VCL9
resolver
uniprot_entry
A0A1X7SB71_MOUSE
resolver
uniprot_entry
HAKAI_MOUSE
resolver
uniprot_sec
Q3TMC0
resolver
uniprot_sec
Q8C7W5
resolver
uniprot_sec
Q8VCL9
resolver
amino_acid_sequence
MDHTDNELQGTNSSGSLGGLDVRRRIPIKLISKQASKVKPAPRTQRTVSRMPAKAPQGDEEGFDYNEEQRYDCKGGELFGNQRRFPGHLFWDFKINILGEKDDTPVHFCDKCGLPIKVYGRMIPCKHVFCYDCAILHEKKGDKMCPGCSDPVQRIEQCTRGSLFMCSIVQGCKRTYLSQRDLQAHINHRHMRAGKPVTRASLENVHPPIAPPPTDIPDRFIMPPDKHHMSHIPPKQHIMMPPPPLQHVPHEHYNQPHEDIRAPPAELSMAPPPPRSVSQETFRISTRKHSNLITVPIQDDSSSGAREPPPPAPAPAHHHPEYQGQPVVSHPHHIMPPQQHYAPPPPPPPPISHPMPHPPQAAGTPHLVYSQAPPPPMTSAPPPITPPPGHIIAQMPPYMNHPPPGPPPPQHGGPPVTAPPPHHYNPNSLPQFTEDQGTLSPPFTQPGGMSPGIWPAPRGPPPPPRMQGPPSQTPLPGPHHPDQTRYRPYYQ
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of several tyrosine-phosphorylated Src substrates, including CDH1, CTTN and DOK1 (PubMed:11836526, PubMed:22252131). Targets CDH1 for endocytosis and degradation (PubMed:11836526). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:29535189, PubMed:29547716). Its function in the WMM complex is unknown (PubMed:29535189, PubMed:29547716). {ECO:0000269|PubMed:11836526, ECO:0000269|PubMed:22252131, ECO:0000269|PubMed:29535189, ECO:0000269|PubMed:29547716}.
uniprot
proteins
mass_dalton
54444
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:11836526}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues. {ECO:0000269|PubMed:11836526}.
uniprot
proteins
protein_family
Hakai family
uniprot
proteins
pubmed
11836526
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
22252131
uniprot
proteins
pubmed
29535189
uniprot
proteins
pubmed
29547716
uniprot
proteins
sequence_length
491
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q75N03}. Nucleus, nucleoplasm {ECO:0000269|PubMed:29547716}. Cytoplasm {ECO:0000269|PubMed:29547716}. Note=Mainly nuclear with some fraction located in the cytoplasm (PubMed:29547716). ZC3H13 is required to anchor component of the MACOM subcomplex, such as VIRMA, in the nucleus (PubMed:29547716). {ECO:0000269|PubMed:29547716}.
uniprot
proteins