Tirap
entrez
117149
canonical
uniprot
Q99JY1
canonical
ensembl
ENSMUSG00000032041
resolver
ensp
ENSMUSP00000135224
resolver
ensp
ENSMUSP00000135435
resolver
ensp
ENSMUSP00000135462
resolver
ensp
ENSMUSP00000135876
resolver
ensp
ENSMUSP00000283240
resolver
enst
ENSMUST00000175765
resolver
enst
ENSMUST00000176531
resolver
enst
ENSMUST00000176685
resolver
enst
ENSMUST00000177129
resolver
genesymbol
Tirap
resolver
genesymbol_syn
Mal
resolver
uniprot
H3BKL1
resolver
uniprot
Q3UB38
resolver
uniprot
Q542S6
resolver
uniprot
Q91ZW0
resolver
uniprot_entry
H3BKL1_MOUSE
resolver
uniprot_entry
Q3UB38_MOUSE
resolver
uniprot_entry
Q542S6_MOUSE
resolver
uniprot_entry
TIRAP_MOUSE
resolver
uniprot_sec
Q91ZW0
resolver
amino_acid_sequence
MASSSSVPASSTPSKKPRDKIADWFRQALLKKPKKMPISQESHLYDGSQTATQDGLSPSSCSSPPSHSSPESRSSPSSCSSGMSPTSPPTHVDSSSSSSGRWSKDYDVCVCHSEEDLEAAQELVSYLEGSQASLRCFLQLRDAAPGGAIVSELCQALSRSHCRALLITPGFLRDPWCKYQMLQALTEAPASEGCTIPLLSGLSRAAYPPELRFMYYVDGRGKDGGFYQVKEAVIHYLETLS
uniprot
proteins
function
FUNCTION: Adapter involved in the TLR2, TLR4 and RAGE signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response (By similarity). Positively regulates the production of TNF and interleukin-6 (By similarity). {ECO:0000250|UniProtKB:P58753}.
uniprot
proteins
mass_dalton
26035
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by IRAK1 and IRAK4. Also phosphorylated by BTK. {ECO:0000250}.; PTM: Polyubiquitinated. Polyubiquitination follows phosphorylation by BTK and leads to TIRAP degradation (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
11526399
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22187460
uniprot
proteins
sequence_length
241
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Membrane {ECO:0000250}. Note=Colocalizes with DAB2IP at the plasma membrane. {ECO:0000250}.
uniprot
proteins