RPS6KA2
entrez
6196
canonical
uniprot
Q15349
canonical
ensembl
ENSG00000071242
resolver
ensp
ENSP00000265678
resolver
ensp
ENSP00000386050
resolver
ensp
ENSP00000422435
resolver
ensp
ENSP00000422484
resolver
ensp
ENSP00000427015
resolver
ensp
ENSP00000519662
resolver
ensp
ENSP00000793731
resolver
enst
ENST00000405189
resolver
enst
ENST00000481261
resolver
enst
ENST00000510118
resolver
genesymbol
RPS6KA2
resolver
genesymbol_syn
MAPKAPK1C
resolver
genesymbol_syn
RSK3
resolver
hgnc
HGNC:10431
resolver
uniprot
B3KTK9
resolver
uniprot
B7Z3B5
resolver
uniprot
F2Z2J1
resolver
uniprot
F6R826
resolver
uniprot
Q15419
resolver
uniprot
Q59GJ3
resolver
uniprot
Q5TI68
resolver
uniprot
Q96J38
resolver
uniprot
Q9UJN5
resolver
uniprot
X5D337
resolver
uniprot_entry
B7Z3B5_HUMAN
resolver
uniprot_entry
F2Z2J1_HUMAN
resolver
uniprot_entry
F6R826_HUMAN
resolver
uniprot_entry
KS6A2_HUMAN
resolver
uniprot_entry
X5D337_HUMAN
resolver
uniprot_sec
B3KTK9
resolver
uniprot_sec
Q15419
resolver
uniprot_sec
Q59GJ3
resolver
uniprot_sec
Q5TI68
resolver
uniprot_sec
Q96J38
resolver
uniprot_sec
Q9UJN5
resolver
activity_regulation
ACTIVITY REGULATION: Upon extracellular signal or mitogen stimulation, phosphorylated at Thr-570 in the C-terminal kinase domain (CTKD) by MAPK1/ERK2 and MAPK3/ERK1. The activated CTKD then autophosphorylates Ser-377, allowing binding of PDPK1, which in turn phosphorylates Ser-218 in the N-terminal kinase domain (NTDK) leading to the full activation of the protein and subsequent phosphorylation of the substrates by the NTKD. {ECO:0000269|PubMed:10480933}.
uniprot
proteins
amino_acid_sequence
MDLSMKKFAVRRFFSVYLRRKSRSKSSSLSRLEEEGVVKEIDISHHVKEGFEKADPSQFELLKVLGQGSYGKVFLVRKVKGSDAGQLYAMKVLKKATLKVRDRVRSKMERDILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSGEAQSLLRALFKRNPCNRLGAGIDGVEEIKRHPFFVTIDWNTLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSPGVPPSANAHHLFRGFSFVASSLIQEPSQQDLHKVPVHPIVQQLHGNNIHFTDGYEIKEDIGVGSYSVCKRCVHKATDTEYAVKIIDKSKRDPSEEIEILLRYGQHPNIITLKDVYDDGKFVYLVMELMRGGELLDRILRQRYFSEREASDVLCTITKTMDYLHSQGVVHRDLKPSNILYRDESGSPESIRVCDFGFAKQLRAGNGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGILLYTMLAGFTPFANGPDDTPEEILARIGSGKYALSGGNWDSISDAAKDVVSKMLHVDPHQRLTAMQVLKHPWVVNREYLSPNQLSRQDVHLVKGAMAATYFALNRTPQAPRLEPVLSSNLAQRRGMKRLTSTRL
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of transcription factors, regulates translation, and mediates cellular proliferation, survival, and differentiation. May function as tumor suppressor in epithelial ovarian cancer cells. {ECO:0000269|PubMed:16878154, ECO:0000269|PubMed:7623830}.
uniprot
proteins
mass_dalton
83239
uniprot
proteins
post_translational_modification
PTM: Activated by phosphorylation at Ser-218 by PDPK1. Autophosphorylated on Ser-377, as part of the activation process. May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 and MAPK3/ERK1 (By similarity). {ECO:0000250}.; PTM: N-terminal myristoylation results in an activated kinase in the absence of added growth factors. {ECO:0000250}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
S6 kinase subfamily
uniprot
proteins
pubmed
10480933
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16878154
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
18813292
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
7623830
uniprot
proteins
pubmed
8141249
uniprot
proteins
sequence_length
733
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:7623830}. Cytoplasm {ECO:0000269|PubMed:7623830}.
uniprot
proteins