P12336
uniprot
P12336
canonical
activity_regulation
ACTIVITY REGULATION: D-glucose and maltose competitively inhibit fructose transport. D-glucose, D-fructose and maltose inhibit deoxyglucose transport. {ECO:0000250|UniProtKB:P11168}.
uniprot
proteins
amino_acid_sequence
MSEDKITGTLAFTVFTAVLGSFQFGYDIGVINAPQEVIISHYRHVLGVPLDDRRATINYDINGTDTPLIVTPAHTTPDAWEEETEGSAHIVTMLWSLSVSSFAVGGMVASFFGGWLGDKLGRIKAMLAANSLSLTGALLMGCSKFGPAHALIIAGRSVSGLYCGLISGLVPMYIGEIAPTTLRGALGTLHQLALVTGILISQIAGLSFILGNQDYWHILLGLSAVPALLQCLLLLFCPESPRYLYLNLEEEVRAKKSLKRLRGTEDITKDINEMRKEKEEASTEQKVSVIQLFTDPNYRQPIVVALMLHLAQQFSGINGIFYYSTSIFQTAGISQPVYATIGVGAINMIFTAVSVLLVEKAGRRTLFLAGMIGMFFCAVFMSLGLVLLDKFTWMSYVSMTAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRPTALALAAFSNWVCNFIIALCFQYIADFLGPYVFFLFAGVVLVFTLFTFFKVPETKGKSFDEIAAEFRKKSGSAPPRKATVQMEFLGSSETV
uniprot
proteins
function
FUNCTION: Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose (PubMed:3048704). Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cells (PubMed:3048704). May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (By similarity). Also able to mediate the transport of dehydroascorbate and urate (By similarity). {ECO:0000250|UniProtKB:P11168, ECO:0000269|PubMed:3048704}.
uniprot
proteins
mass_dalton
57086
uniprot
proteins
post_translational_modification
PTM: N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells. {ECO:0000250|UniProtKB:P14246}.
uniprot
proteins
protein_family
Glucose transporter subfamily
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Sugar transporter (TC 2.A.1.1) family
uniprot
proteins
pubmed
3048704
uniprot
proteins
pubmed
7487103
uniprot
proteins
sequence_length
522
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:3048704}; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 11..31; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 97..117; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 126..146; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 157..177; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 186..206; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 216..236; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 302..322; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 338..358; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 366..386; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 402..422; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 432..452; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 460..480; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins