Aunip
entrez
69885
canonical
uniprot
E9Q6Z5
canonical
ensembl
ENSMUSG00000078521
resolver
ensp
ENSMUSP00000101492
resolver
enst
ENSMUST00000105866
resolver
genesymbol
Aunip
resolver
uniprot
B2RR86
resolver
uniprot_entry
AUNIP_MOUSE
resolver
uniprot_sec
B2RR86
resolver
amino_acid_sequence
MRHRGPEEEACGVWLDAAALKRRKMQTHLIKLGTKMLPLLPGERKPNDPFTQRRGTRQTSIASFVTLQSGMASGGNQKNIFSLKENQTNKECKRTQLDCLDDGLLSPLVTSAPADIQEAGHPRSPQISGCQGLEMSSLTMMSLTQPDVLMGTGESKGPLDSSFSQYLERSCLLDQREAKRKGEGLRESKTDCPGMGSHIRPPGSKCHQPLDKAEMGKRGPTKENRQAPVHLQTYRSGSCSRKKTLLVTESPCPLSLFPWDSERSDRDSWSQLFTEDSQGQQVIAHNTKMPFRDVTNARNQGSGQFPDSPQAQGQDGPAQLHLQSYLLFTQDSEGNRVIRH
uniprot
proteins
function
FUNCTION: DNA-binding protein that accumulates at DNA double-strand breaks (DSBs) following DNA damage and promotes DNA resection and homologous recombination. Serves as a sensor of DNA damage: binds DNA with a strong preference for DNA substrates that mimic structures generated at stalled replication forks, and anchors RBBP8/CtIP to DSB sites to promote DNA end resection and ensuing homologous recombination repair. Inhibits non-homologous end joining (NHEJ). Required for the dynamic movement of AURKA at the centrosomes and spindle apparatus during the cell cycle. {ECO:0000250|UniProtKB:Q9H7T9}.
uniprot
proteins
mass_dalton
37684
uniprot
proteins
protein_family
AUNIP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
340
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H7T9}. Chromosome {ECO:0000250|UniProtKB:Q9H7T9}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9H7T9}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q9H7T9}. Note=Accumulates at sites of DNA damage by binding to DNA substrates that mimick structures generated at stalled replication forks. Localizes to the centrosome in interphase and to the spindle pole in metaphase. {ECO:0000250|UniProtKB:Q9H7T9}.
uniprot
proteins