BAG5
entrez
9529
canonical
uniprot
Q9UL15
canonical
ensembl
ENSG00000166170
resolver
ensp
ENSP00000299204
resolver
ensp
ENSP00000338814
resolver
ensp
ENSP00000391713
resolver
genesymbol
BAG5
resolver
genesymbol_syn
KIAA0873
resolver
hgnc
HGNC:941
resolver
uniprot
A0A024R6M6
resolver
uniprot
O94950
resolver
uniprot
Q86W59
resolver
uniprot_entry
A0A024R6M6_HUMAN
resolver
uniprot_entry
BAG5_HUMAN
resolver
uniprot_sec
O94950
resolver
uniprot_sec
Q86W59
resolver
amino_acid_sequence
MDMGNQHPSISRLQEIQKEVKSVEQQVIGFSGLSDDKNYKKLERILTKQLFEIDSVDTEGKGDIQQARKRAAQETERLLKELEQNANHPHRIEIQNIFEEAQSLVREKIVPFYNGGNCVTDEFEEGIQDIILRLTHVKTGGKISLRKARYHTLTKICAVQEIIEDCMKKQPSLPLSEDAHPSVAKINFVMCEVNKARGVLIALLMGVNNNETCRHLSCVLSGLIADLDALDVCGRTEIRNYRREVVEDINKLLKYLDLEEEADTTKAFDLRQNHSILKIEKVLKRMREIKNELLQAQNPSELYLSSKTELQGLIGQLDEVSLEKNPCIREARRRAVIEVQTLITYIDLKEALEKRKLFACEEHPSHKAVWNVLGNLSEIQGEVLSFDGNRTDKNYIRLEELLTKQLLALDAVDPQGEEKCKAARKQAVRLAQNILSYLDLKSDEWEY
uniprot
proteins
disease_involvement
DISEASE: Cardiomyopathy, dilated, 2F (CMD2F) [MIM:619747]: A form of dilated cardiomyopathy, a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. CMD2F is an autosomal recessive, early-onset form. {ECO:0000269|PubMed:35044787}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Co-chaperone for HSP/HSP70 proteins. It functions as a nucleotide-exchange factor promoting the release of ADP from HSP70, thereby activating HSP70-mediated protein refolding (PubMed:20223214). Has an essential role in maintaining proteostasis at junctional membrane complexes (JMC), where it may function as a scaffold between the HSPA8 chaperone and JMC proteins enabling correct, HSPA8-dependent JMC protein folding (By similarity). Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). {ECO:0000250|UniProtKB:Q5QJC9, ECO:0000250|UniProtKB:Q8CI32, ECO:0000269|PubMed:20223214}.
uniprot
proteins
mass_dalton
51200
uniprot
proteins
pubmed
10048485
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20223214
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24270810
uniprot
proteins
pubmed
35044787
uniprot
proteins
pubmed
9873016
uniprot
proteins
sequence_length
447
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Note=In cardiomyocytes, localized at specialized membrane contact sites between T-tubules and the sarcoplasmic reticulum, known as junctional membrane complexes. {ECO:0000250|UniProtKB:Q8CI32}.
uniprot
proteins