Purb
entrez
498407
canonical
uniprot
Q68A21
canonical
ensembl
ENSRNOG00000062895
resolver
ensp
ENSRNOP00000079672
resolver
genesymbol
Purb
resolver
uniprot_entry
PURB_RAT
resolver
amino_acid_sequence
MADGDSGSERGGGGPGSFQPAPRGGGGPGGEQETQELASKRLDIQNKRFYLDVKQNAKGRFLKIAEVGAGGSKSRLTLSMAVAAEFRDSLGDFIEHYAQLGPSSPEQLAAGAEEGGGPRRALKSEFLVRENRKYYLDLKENQRGRFLRIRQTVNRGGGGFGGGPGPGGLQSGQTIALPAQGLIEFRDALAKLIDDYGGEDDELAGGPGGGAGGPGGGLYGELPEGTSITVDSKRFFFDVGCNKYGVFLRVSEVKPSYRNAITVPFKAWGKFGGAFCRYADEMKEIQERQRDKLYERRGGGSGGGDESEGEEVDED
uniprot
proteins
function
FUNCTION: Transcriptional regulator which can act as an activator or a repressor. Represses the transcription of ACTA2 in fibroblasts and smooth muscle cells via its ability to interact with the purine-rich strand of a MCAT- containing element in the 5' flanking region of the gene. Represses the transcription of MYOCD, capable of repressing all isoforms of MYOCD but the magnitude of the repressive effects is most notable for the SMC- specific isoforms. Promotes hepatic glucose production by activating the transcription of ADCY6, leading to cAMP accumulation, increased PKA activity, CREB activation, and increased transcription of PCK1 and G6PC genes. Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene (By similarity). Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element (PubMed:12933792). Modulates constitutive liver galectin-3 gene transcription by binding to its promoter (PubMed:16309856). May play a role in the dendritic transport of a subset of mRNAs (PubMed:11032866). {ECO:0000250|UniProtKB:O35295, ECO:0000250|UniProtKB:Q96QR8, ECO:0000269|PubMed:11032866, ECO:0000269|PubMed:12933792, ECO:0000269|PubMed:16309856}.
uniprot
proteins
mass_dalton
33418
uniprot
proteins
protein_family
PUR DNA-binding protein family
uniprot
proteins
pubmed
11032866
uniprot
proteins
pubmed
12933792
uniprot
proteins
pubmed
16309856
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
315
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O35295}.
uniprot
proteins