RNF114
entrez
55905
canonical
uniprot
Q9Y508
canonical
ensembl
ENSG00000124226
resolver
ensp
ENSP00000244061
resolver
genesymbol
RNF114
resolver
genesymbol_syn
ZNF228
resolver
genesymbol_syn
ZNF313
resolver
hgnc
HGNC:13094
resolver
uniprot
B2RDQ9
resolver
uniprot
B4DWY5
resolver
uniprot
E1P627
resolver
uniprot
Q6N0B0
resolver
uniprot_entry
RN114_HUMAN
resolver
uniprot_sec
B2RDQ9
resolver
uniprot_sec
B4DWY5
resolver
uniprot_sec
E1P627
resolver
uniprot_sec
Q6N0B0
resolver
amino_acid_sequence
MAAQQRDCGGAAQLAGPAAEADPLGRFTCPVCLEVYEKPVQVPCGHVFCSACLQECLKPKKPVCGVCRSALAPGVRAVELERQIESTETSCHGCRKNFFLSKIRSHVATCSKYQNYIMEGVKATIKDASLQPRNVPNRYTFPCPYCPEKNFDQEGLVEHCKLFHSTDTKSVVCPICASMPWGDPNYRSANFREHIQRRHRFSYDTFVDYDVDEEDMMNQVLQRSIIDQ
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates (PubMed:23645206, PubMed:25165885). In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity (PubMed:25165885, PubMed:28708287). Acts as a negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3 (PubMed:25165885). May promote the ubiquitination of TRAF6 as well (PubMed:28708287). Also acts as a negative regulator of T-cell activation (PubMed:25165885). Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation (PubMed:25165885). Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C (PubMed:23645206). This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence. May play a role in spermatogenesis. {ECO:0000269|PubMed:23645206, ECO:0000269|PubMed:25165885, ECO:0000269|PubMed:28625874, ECO:0000269|PubMed:28708287}.
uniprot
proteins
mass_dalton
25694
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:23645206}.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. Polyubiquitinated in the presence of E2 enzymes UBE2D1, UBE2D2 and UBE2D3, but only monoubiquitinated in the presence of UBE2E1. {ECO:0000269|PubMed:23645206}.
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12621547
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18364390
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23645206
uniprot
proteins
pubmed
25165885
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28625874
uniprot
proteins
pubmed
28708287
uniprot
proteins
sequence_length
228
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23645206}. Nucleus {ECO:0000269|PubMed:23645206}.
uniprot
proteins