Kiss1r
entrez
114229
canonical
uniprot
Q91V45
canonical
ensembl
ENSMUSG00000035773
resolver
ensp
ENSMUSP00000040516
resolver
ensp
ENSMUSP00000151936
resolver
ensp
ENSMUSP00000308077
resolver
enst
ENSMUST00000045529
resolver
enst
ENSMUST00000219745
resolver
genesymbol
Kiss1r
resolver
genesymbol_syn
Gpr54
resolver
uniprot
A0A1W2P847
resolver
uniprot
B2CP06
resolver
uniprot
C5H7S2
resolver
uniprot
Q8K3P2
resolver
uniprot_entry
A0A1W2P847_MOUSE
resolver
uniprot_entry
B2CP06_MOUSE
resolver
uniprot_entry
C5H7S2_MOUSE
resolver
uniprot_entry
KISSR_MOUSE
resolver
uniprot_sec
Q8K3P2
resolver
amino_acid_sequence
MATEATLAPNVTWWAPSNASGCPGCGVNASDDPGSAPRPLDAWLVPLFFATLMLLGLVGNSLVIYVICRHKHMQTVTNFYIANLAATDVTFLLCCVPFTALLYPLPAWVLGDFMCKFVNYIQQVSVQATCATLTAMSVDRWYVTVFPLRALHRRTPRLALAVSLSIWVGSAAVSAPVLALHRLSPGPRTYCSEAFPSRALERAFALYNLLALYLLPLLATCACYGAMLRHLGRAAVRPAPTDGALQGQLLAQRAGAVRTKVSRLVAAVVLLFAACWGPIQLFLVLQALGPSGAWHPRSYAAYAVKIWAHCMSYSNSALNPLLYAFLGSHFRQAFCRVCPCCRQRQRRPHTSAHSDRAATHTVPHSRAAHPVRIRSPEPGNPVVRSPCAQSERTASL
uniprot
proteins
function
FUNCTION: Receptor for kisspeptins (kisspeptin-10, kisspeptin-13, kisspeptin-14 and metastin/kisspeptin-54) (PubMed:12359743). The hypothalamic KISS1/KISS1R signaling system plays a central role in the regulation of the hypothalamic-pituitary-gonadal reproductive axis by modulating the secretion of gonadotropin-releasing hormone (GnRH) from GnRH neurons (PubMed:14573733, PubMed:14652023, PubMed:15665093). In these neurons, kisspeptin binding to its receptor activates G(q)-dependent signaling, leading to phospholipase C (PLC) activation, and hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2). The subsequent rise in intracellular calcium levels results in the inhibition of inward rectifier potassium channels and activation of TRPC-like cation channels, leading to GnRH neurons depolarization and stimulation (PubMed:18434521, PubMed:18483150). In addition to this pathway, kisspeptin also triggers G(q)-independent signaling via beta-arrestin, leading to MAPK cascade activation and ERK1/ERK2 phosphorylation (PubMed:25147978). In bone tissue, activation of KISS1R by kisspeptin-10 recruits phosphatase DUSP18 and SRC to the KISS1R C-terminus through a G(q)-dependent signaling pathway. This leads to DUSP18-mediated dephosphorylation of SRC, down-regulation of osteoclast differentiation and activity, and consequently suppression of bone resorption (PubMed:38346942). KISS1R is also involved in the regulation of other processes, including cell proliferation and cell migration (PubMed:12359743). {ECO:0000269|PubMed:12359743, ECO:0000269|PubMed:14573733, ECO:0000269|PubMed:14652023, ECO:0000269|PubMed:15665093, ECO:0000269|PubMed:18434521, ECO:0000269|PubMed:18483150, ECO:0000269|PubMed:25147978, ECO:0000269|PubMed:38346942}.
uniprot
proteins
mass_dalton
43061
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11414709
uniprot
proteins
pubmed
12359743
uniprot
proteins
pubmed
14573733
uniprot
proteins
pubmed
14652023
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15519892
uniprot
proteins
pubmed
15665093
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18434521
uniprot
proteins
pubmed
18483150
uniprot
proteins
pubmed
25147978
uniprot
proteins
pubmed
38346942
uniprot
proteins
pubmed
39702286
uniprot
proteins
sequence_length
396
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q969F8}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 44..66; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 79..101; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 117..138; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 158..180; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 204..224; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 261..283; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 306..330; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins