Slc10a1
entrez
20493
canonical
uniprot
O08705
canonical
ensembl
ENSMUSG00000021135
resolver
ensp
ENSMUSP00000093229
resolver
ensp
ENSMUSP00000151215
resolver
ensp
ENSMUSP00000151555
resolver
enst
ENSMUST00000218342
resolver
genesymbol
Slc10a1
resolver
genesymbol_syn
Ntcp
resolver
uniprot
A0A8V5KH54
resolver
uniprot
O35940
resolver
uniprot
Q52L86
resolver
uniprot_entry
A0A8V5KH54_MOUSE
resolver
uniprot_entry
NTCP_MOUSE
resolver
uniprot_sec
O35940
resolver
uniprot_sec
Q52L86
resolver
activity_regulation
ACTIVITY REGULATION: The transport of bile acids is sodium-dependent. {ECO:0000250|UniProtKB:Q14973}.
uniprot
proteins
amino_acid_sequence
MEAHNVSAPFNFSLPPGFGHRATDTALSVILVVMLLLIMLSLGCTMEFSKIKAHFWKPKGVIIAIVAQYGIMPLSAFLLGKVFHLTSIEALAILICGCSPGGNLSNLFTLAMKGDMNLSIVMTTCSSFTALGMMPLLLYIYSKGIYDGDLKDKVPYKGIMLSLVMVLIPCAIGIFLKSKRPHYVPYVLKAGMIITFSLSVAVTVLSVINVGNSIMFVMTPHLLATSSLMPFTGFLMGYILSALFRLNPSCRRTISMETGFQNVQLCSTILNVTFPPEVIGPLFFFPLLYMIFQLAEGLLFIIIFRCYLKIKPQKDQTKITYKAAATEDATPAALEKGTHNGNNPPTQPGLSPNGLNSGQMAN
uniprot
proteins
function
FUNCTION: As a major transporter of conjugated bile salts from plasma into the hepatocyte, it plays a key role in the enterohepatic circulation of bile salts necessary for the solubilization and absorption of dietary fat and fat-soluble vitamins (PubMed:10209268). It is strictly dependent on the extracellular presence of sodium (PubMed:10209268, PubMed:34060352). It exhibits broad substrate specificity and transports various bile acids, such as taurocholate, cholate, as well as non-bile acid organic compounds, such as estrone sulfate (PubMed:10209268, PubMed:34060352). Works collaboratively with the ileal transporter (NTCP2), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (By similarity). {ECO:0000250|UniProtKB:Q14973, ECO:0000269|PubMed:10209268, ECO:0000269|PubMed:34060352}.
uniprot
proteins
mass_dalton
39413
uniprot
proteins
protein_family
Bile acid:sodium symporter (BASS) (TC 2.A.28) family
uniprot
proteins
pubmed
10209268
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
34060352
uniprot
proteins
sequence_length
362
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q14973}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q14973}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..44; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q14973"; TRANSMEM 48..83; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q14973"; TRANSMEM 87..112; /note="Discontinuously helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q14973"; TRANSMEM 116..142; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q14973"; TRANSMEM 157..179; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q14973"; TRANSMEM 184..217; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q14973"; TRANSMEM 220..243; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q14973"; TRANSMEM 248..273; /note="Discontinuously helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q14973"; TRANSMEM 281..311; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q14973
uniprot
proteins