SMIM30
entrez
401397
canonical
uniprot
A4D0T7
canonical
ensembl
ENSG00000214194
resolver
ensp
ENSP00000490064
resolver
ensp
ENSP00000490095
resolver
ensp
ENSP00000551871
resolver
ensp
ENSP00000584361
resolver
enst
ENST00000397764
resolver
enst
ENST00000441359
resolver
enst
ENST00000881812
resolver
enst
ENST00000914302
resolver
genesymbol
SMIM30
resolver
genesymbol_syn
MAVI1
resolver
hgnc
HGNC:48953
resolver
uniprot
Q32Q38
resolver
uniprot_entry
SIM30_HUMAN
resolver
uniprot_sec
Q32Q38
resolver
amino_acid_sequence
MTSVSTQLSLVLMSLLLVLPVVEAVEAGDAIALLLGVVLSITGICACLGVYARKRNGQM
uniprot
proteins
function
FUNCTION: Negatively regulates antiviral innate immune responses (PubMed:37656786). Disrupts the interaction of antiviral protein MAVS with innate immune receptor RIGI and inhibits MAVS aggregation, resulting in the repression of type I interferon signaling and innate immune responses (PubMed:37656786). {ECO:0000269|PubMed:37656786}.
uniprot
proteins
mass_dalton
6102
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
37656786
uniprot
proteins
sequence_length
59
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:37656786}; Single-pass type I membrane protein {ECO:0000269|PubMed:37656786}. Mitochondrion membrane {ECO:0000269|PubMed:37656786}; Single-pass type I membrane protein {ECO:0000269|PubMed:37656786}.
uniprot
proteins
transmembrane_region
TRANSMEM 30..50; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins