P0DW81
uniprot
P0DW81
canonical
amino_acid_sequence
MAASGGTKKAQSGGRRLREPSSRPSRRARQRPRRGALRKAGRFL
uniprot
proteins
function
FUNCTION: Micropeptide that acts as a regulator of DNA repair both by preventing KLHL15-mediated ubiquitination and degradation of RBBP8/CtIP, and by promoting the poly-ADP-ribosyltransferase activity of PARP1 (PubMed:35219381). Prevents KLHL15-mediated ubiquitination of RBBP8/CtIP by competitively blocking the association between KLHL15 and RBBP8/CtIP (PubMed:35219381). Recruited to DNA damage sites via association with poly-ADP-ribose chains, and enhances the poly-ADP-ribosyltransferase activity of PARP1 (PubMed:35219381). {ECO:0000269|PubMed:35219381}.
uniprot
proteins
mass_dalton
4877
uniprot
proteins
mutagenesis
MUTAGEN 23..42; /note="RPSRRARQRPRRGALRKAGR->APSAAAAQAPAAGALRAAGA: In 10A mutant; impaired binding to poly-ADP-ribose chains."; /evidence="ECO:0000269|PubMed:35219381"; MUTAGEN 38..42; /note="RKAGR->AAAGA: In 4A mutant; impaired binding to poly-ADP-ribose chains."; /evidence="ECO:0000269|PubMed:35219381
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
35219381
uniprot
proteins
sequence_length
44
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:35219381}. Chromosome {ECO:0000269|PubMed:35219381}. Note=Recruited to DNA damage sites via interaction with poly-ADP-ribose chains. {ECO:0000269|PubMed:35219381}.
uniprot
proteins