TARBP2
entrez
6895
canonical
uniprot
Q15633
canonical
ensembl
ENSG00000139546
resolver
ensp
ENSP00000266987
resolver
ensp
ENSP00000377885
resolver
ensp
ENSP00000416077
resolver
ensp
ENSP00000447767
resolver
genesymbol
TARBP2
resolver
genesymbol_syn
TRBP
resolver
hgnc
HGNC:11569
resolver
uniprot
Q12878
resolver
uniprot
Q8WY32
resolver
uniprot
Q8WY33
resolver
uniprot
Q9BRY2
resolver
uniprot_entry
TRBP2_HUMAN
resolver
uniprot_sec
Q12878
resolver
uniprot_sec
Q8WY32
resolver
uniprot_sec
Q8WY33
resolver
uniprot_sec
Q9BRY2
resolver
amino_acid_sequence
MSEEEQGSGTTTGCGLPSIEQMLAANPGKTPISLLQEYGTRIGKTPVYDLLKAEGQAHQPNFTFRVTVGDTSCTGQGPSKKAAKHKAAEVALKHLKGGSMLEPALEDSSSFSPLDSSLPEDIPVFTAAAAATPVPSVVLTRSPPMELQPPVSPQQSECNPVGALQELVVQKGWRLPEYTVTQESGPAHRKEFTMTCRVERFIEIGSGTSKKLAKRNAAAKMLLRVHTVPLDARDGNEVEPDDDHFSIGVGSRLDGLRNRGPGCTWDSLRNSVGEKILSLRSCSLGSLGALGPACCRVLSELSEEQAFHVSYLDIEELSLSGLCQCLVELSTQPATVCHGSATTREAARGEAARRALQYLKIMAGSK
uniprot
proteins
function
FUNCTION: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1 (By similarity) (PubMed:15973356, PubMed:16142218, PubMed:16271387, PubMed:16357216, PubMed:16424907, PubMed:17452327, PubMed:18178619). Binds in vitro to the PRM1 3'-UTR (By similarity). Seems to act as a repressor of translation (By similarity). For some pre-miRNA substrates, may also alter the choice of cleavage site by DICER1 (PubMed:23063653). Negatively regulates IRF7-mediated IFN-beta signaling triggered by viral infection by inhibiting the phosphorylation of IRF7 and promoting its 'Lys'-48-linked ubiquitination and degradation (PubMed:30927622). {ECO:0000250|UniProtKB:P97473, ECO:0000255|HAMAP-Rule:MF_03034, ECO:0000269|PubMed:15973356, ECO:0000269|PubMed:16142218, ECO:0000269|PubMed:16271387, ECO:0000269|PubMed:16357216, ECO:0000269|PubMed:16424907, ECO:0000269|PubMed:17452327, ECO:0000269|PubMed:18178619, ECO:0000269|PubMed:23063653, ECO:0000269|PubMed:30927622}.; FUNCTION: (Microbial infection) Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs (PubMed:11438532, PubMed:12475984, PubMed:2011739). This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha (PubMed:11438532). May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR (PubMed:12475984). Mediates recruitment of FTSJ3 methyltransferase to HIV-1 RNA, leading to 2'-O-methylation of the viral genome, allowing HIV-1 to escape the innate immune system (PubMed:30626973). {ECO:0000269|PubMed:11438532, ECO:0000269|PubMed:12475984, ECO:0000269|PubMed:2011739, ECO:0000269|PubMed:30626973}.
uniprot
proteins
mass_dalton
39039
uniprot
proteins
protein_family
TARBP2 family
uniprot
proteins
pubmed
11438532
uniprot
proteins
pubmed
11641396
uniprot
proteins
pubmed
12475984
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15973356
uniprot
proteins
pubmed
16142218
uniprot
proteins
pubmed
16271387
uniprot
proteins
pubmed
16357216
uniprot
proteins
pubmed
16424907
uniprot
proteins
pubmed
17452327
uniprot
proteins
pubmed
17507929
uniprot
proteins
pubmed
17531811
uniprot
proteins
pubmed
18178619
uniprot
proteins
pubmed
18421256
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19219043
uniprot
proteins
pubmed
2011739
uniprot
proteins
pubmed
21228243
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23063653
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26813765
uniprot
proteins
pubmed
30626973
uniprot
proteins
pubmed
30927622
uniprot
proteins
pubmed
7774957
uniprot
proteins
pubmed
8455607
uniprot
proteins
sequence_length
366
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, perinuclear region. Nucleus.
uniprot
proteins