SLMAP
entrez
7871
canonical
uniprot
Q14BN4
canonical
ensembl
ENSG00000163681
resolver
ensp
ENSP00000295951
resolver
ensp
ENSP00000373224
resolver
ensp
ENSP00000391886
resolver
ensp
ENSP00000398661
resolver
ensp
ENSP00000412829
resolver
ensp
ENSP00000412945
resolver
ensp
ENSP00000418218
resolver
ensp
ENSP00000419849
resolver
ensp
ENSP00000499241
resolver
ensp
ENSP00000499458
resolver
ensp
ENSP00000499520
resolver
ensp
ENSP00000499553
resolver
ensp
ENSP00000516144
resolver
ensp
ENSP00000516145
resolver
ensp
ENSP00000516148
resolver
ensp
ENSP00000516150
resolver
ensp
ENSP00000535113
resolver
ensp
ENSP00000535114
resolver
ensp
ENSP00000535115
resolver
ensp
ENSP00000535116
resolver
ensp
ENSP00000606774
resolver
ensp
ENSP00000627923
resolver
ensp
ENSP00000649140
resolver
ensp
ENSP00000649141
resolver
ensp
ENSP00000649142
resolver
ensp
ENSP00000649143
resolver
ensp
ENSP00000709458
resolver
ensp
ENSP00000709459
resolver
ensp
ENSP00000709461
resolver
ensp
ENSP00000709462
resolver
ensp
ENSP00000756797
resolver
enst
ENST00000417128
resolver
enst
ENST00000428312
resolver
enst
ENST00000465203
resolver
enst
ENST00000670768
resolver
enst
ENST00000671191
resolver
enst
ENST00000705628
resolver
genesymbol
SLMAP
resolver
genesymbol_syn
KIAA1601
resolver
genesymbol_syn
SLAP
resolver
hgnc
HGNC:16643
resolver
uniprot
A0A590UJK3
resolver
uniprot
A0A590UJS6
resolver
uniprot
A0A5F9VB99
resolver
uniprot
A0A994J5K5
resolver
uniprot
B7Z6C7
resolver
uniprot
B7Z863
resolver
uniprot
B7Z964
resolver
uniprot
H7C3M8
resolver
uniprot
H7C5G9
resolver
uniprot
Q14C95
resolver
uniprot
Q6AI54
resolver
uniprot
Q6UXC9
resolver
uniprot
Q6ZVQ8
resolver
uniprot
Q8NCW9
resolver
uniprot
Q9H297
resolver
uniprot
Q9HCH1
resolver
uniprot
Q9Y681
resolver
uniprot_entry
A0A590UJK3_HUMAN
resolver
uniprot_entry
A0A590UJS6_HUMAN
resolver
uniprot_entry
A0A5F9VB99_HUMAN
resolver
uniprot_entry
A0A994J5K5_HUMAN
resolver
uniprot_entry
B7Z6C7_HUMAN
resolver
uniprot_entry
B7Z863_HUMAN
resolver
uniprot_entry
B7Z964_HUMAN
resolver
uniprot_entry
H7C3M8_HUMAN
resolver
uniprot_entry
H7C5G9_HUMAN
resolver
uniprot_entry
SLMAP_HUMAN
resolver
uniprot_sec
Q14C95
resolver
uniprot_sec
Q6AI54
resolver
uniprot_sec
Q6UXC9
resolver
uniprot_sec
Q6ZVQ8
resolver
uniprot_sec
Q8NCW9
resolver
uniprot_sec
Q9H297
resolver
uniprot_sec
Q9HCH1
resolver
uniprot_sec
Q9Y681
resolver
amino_acid_sequence
MPSALAIFTCRPNSHPFQERHVYLDEPIKIGRSVARCRPAQNNATFDCKVLSRNHALVWFDHKTGKFYLQDTKSSNGTFINSQRLSRGSEESPPCEILSGDIIQFGVDVTENTRKVTHGCIVSTIKLFLPDGMEARLRSDVIHAPLPSPVDKVAANTPSMYSQELFQLSQYLQEALHREQMLEQKLATLQRLLAITQEASDTSWQALIDEDRLLSRLEVMGNQLQACSKNQTEDSLRKELIALQEDKHNYETTAKESLRRVLQEKIEVVRKLSEVERSLSNTEDECTHLKEMNERTQEELRELANKYNGAVNEIKDLSDKLKVAEGKQEEIQQKGQAEKKELQHKIDEMEEKEQELQAKIEALQADNDFTNERLTALQVRLEHLQEKTLKECSSLEHLLSKSGGDCTFIHQFIECQKKLIVEGHLTKAVEETKLSKENQTRAKESDFSDTLSPSKEKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGAQSEIEAKQEIQHLRKELIEAQELARTSKQKCFELQALLEEERKAYRNQVEESTKQIQVLQAQLQRLHIDTENLREEKDSEITSTRDELLSARDEILLLHQAAAKVASERDTDIASLQEELKKVRAELERWRKAASEYEKEITSLQNSFQLRCQQCEDQQREEATRLQGELEKLRKEWNALETECHSLKRENVLLSSELQRQEKELHNSQKQSLELTSDLSILQMSRKELENQVGSLKEQHLRDSADLKTLLSKAENQAKDVQKEYEKTQTVLSELKLKFEMTEQEKQSITDELKQCKNNLKLLREKGNNKPWPWMPMLAALVAVTAIVLYVPGLARASP
uniprot
proteins
function
FUNCTION: Associates with the striatin-interacting phosphatase and kinase (STRIPAK) core complex, forming the extended (SIKE1:SLMAP)STRIPAK complex (PubMed:29063833, PubMed:30622739). The (SIKE1:SLMAP)STRIPAK complex dephosphorylates STK3 leading to the inhibition of Hippo signaling and the control of cell growth (PubMed:29063833, PubMed:30622739). May play a role during myoblast fusion (By similarity). {ECO:0000250|UniProtKB:Q3URD3, ECO:0000269|PubMed:29063833, ECO:0000269|PubMed:30622739}.
uniprot
proteins
mass_dalton
95198
uniprot
proteins
mutagenesis
MUTAGEN 182; /note="L->D: Loss of interaction with SIKE1."; /evidence="ECO:0000269|PubMed:30622739"; MUTAGEN 186; /note="L->D: Loss of interaction with SIKE1."; /evidence="ECO:0000269|PubMed:30622739"; MUTAGEN 189; /note="L->D: Loss of interaction with SIKE1."; /evidence="ECO:0000269|PubMed:30622739"; MUTAGEN 193; /note="L->D: Loss of interaction with SIKE1."; /evidence="ECO:0000269|PubMed:30622739"; MUTAGEN 799; /note="K->L: No effect on location to mitochondrion membrane; when associated with L-825."; /evidence="ECO:0000269|PubMed:19538755"; MUTAGEN 808..815; /note="AALVAVTA->LLLVAVLL: Loss of mitochondrion membrane location."; /evidence="ECO:0000269|PubMed:19538755"; MUTAGEN 808..809; /note="AA->LL: Loss of mitochondrion membrane location."; /evidence="ECO:0000269|PubMed:19538755"; MUTAGEN 825; /note="R->L: No effect on location to mitochondrion membrane; when associated with K-799."; /evidence="ECO:0000269|PubMed:19538755
uniprot
proteins
protein_family
SLMAP family
uniprot
proteins
pubmed
10986292
uniprot
proteins
pubmed
10997877
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19538755
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29063833
uniprot
proteins
pubmed
30622739
uniprot
proteins
sequence_length
828
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P0C219}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:P0C219}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250|UniProtKB:Q3URD3}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:Q3URD3}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q3URD3}. Note=Membrane-associated. Distributed in the transverse tubules and near the junctional sarcoplasmic reticulum (By similarity). Detected along the Z- and M-lines in cardiomyocytes (By similarity). {ECO:0000250|UniProtKB:P0C219, ECO:0000250|UniProtKB:Q3URD3}.; SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19538755}; Single-pass type IV membrane protein {ECO:0000269|PubMed:19538755}. Mitochondrion membrane {ECO:0000269|PubMed:19538755}; Single-pass type IV membrane protein {ECO:0000269|PubMed:19538755}.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19538755}; Single-pass type IV membrane protein {ECO:0000269|PubMed:19538755}. Mitochondrion membrane {ECO:0000269|PubMed:19538755}; Single-pass type IV membrane protein {ECO:0000269|PubMed:19538755}.; SUBCELLULAR LOCATION: [Isoform 3]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19538755}; Single-pass type IV membrane protein {ECO:0000269|PubMed:19538755}. Mitochondrion membrane {ECO:0000269|PubMed:19538755}; Single-pass type IV membrane protein {ECO:0000269|PubMed:19538755}.; SUBCELLULAR LOCATION: [Isoform 4]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19538755}; Single-pass type IV membrane protein {ECO:0000269|PubMed:19538755}. Mitochondrion membrane {ECO:0000269|PubMed:19538755}; Single-pass type IV membrane protein {ECO:0000269|PubMed:19538755}.; SUBCELLULAR LOCATION: [Isoform 5]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:19538755}; Single-pass type IV membrane protein {ECO:0000269|PubMed:19538755}. Note=Do not localize at the mitochondrial membrane. {ECO:0000269|PubMed:19538755}.
uniprot
proteins
transmembrane_region
TRANSMEM 803..823; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255"; TRANSMEM Q14BN4-5:339..359; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000269|PubMed:10986292
uniprot
proteins