ST6GALNAC5
entrez
81849
canonical
uniprot
Q9BVH7
canonical
ensembl
ENSG00000117069
resolver
ensp
ENSP00000417583
resolver
ensp
ENSP00000652498
resolver
ensp
ENSP00000790855
resolver
enst
ENST00000477717
resolver
genesymbol
ST6GALNAC5
resolver
genesymbol_syn
SIAT7E
resolver
hgnc
HGNC:19342
resolver
uniprot
B1AK82
resolver
uniprot
B4DV27
resolver
uniprot_entry
B4DV27_HUMAN
resolver
uniprot_entry
SIA7E_HUMAN
resolver
uniprot_sec
B1AK82
resolver
amino_acid_sequence
MKTLMRHGLAVCLALTTMCTSLLLVYSSLGGQKERPPQQQQQQQQQQQQASATGSSQPAAESSTQQRPGVPAGPRPLDGYLGVADHKPLKMHCRDCALVTSSGHLLHSRQGSQIDQTECVIRMNDAPTRGYGRDVGNRTSLRVIAHSSIQRILRNRHDLLNVSQGTVFIFWGPSSYMRRDGKGQVYNNLHLLSQVLPRLKAFMITRHKMLQFDELFKQETGKDRKISNTWLSTGWFTMTIALELCDRINVYGMVPPDFCRDPNHPSVPYHYYEPFGPDECTMYLSHERGRKGSHHRFITEKRVFKNWARTFNIHFFQPDWKPESLAINHPENKPVF
uniprot
proteins
ec_number
2.4.99.-
uniprot
proteins
function
FUNCTION: Predominantly catalyzes the biosynthesis of ganglioside GD1alpha from GM1b in the brain, by transferring the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of GM1b (PubMed:12668675). GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (By similarity). Also shows activity towards sialyl Lc4Cer (N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine) generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen (PubMed:12668675). {ECO:0000250|UniProtKB:Q9QYJ1, ECO:0000269|PubMed:12668675}.
uniprot
proteins
mass_dalton
38443
uniprot
proteins
pathway_participation
PATHWAY: Glycolipid biosynthesis. {ECO:0000305|PubMed:12668675}.
uniprot
proteins
protein_family
Glycosyltransferase 29 family
uniprot
proteins
pubmed
12668675
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
sequence_length
336
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins