Gpr12
entrez
14738
canonical
uniprot
P35412
canonical
ensembl
ENSMUSG00000041468
resolver
ensp
ENSMUSP00000038245
resolver
ensp
ENSMUSP00000142889
resolver
ensp
ENSMUSP00000186932
resolver
ensp
ENSMUSP00000362566
resolver
enst
ENSMUST00000036211
resolver
enst
ENSMUST00000197431
resolver
genesymbol
Gpr12
resolver
genesymbol_syn
Gpcr12
resolver
uniprot_entry
GPR12_MOUSE
resolver
amino_acid_sequence
MNEDPKVNLSGLPRDCIDAGAPENISAAVPSQGSVAESEPELVVNPWDIVLCSSGTLICCENAVVVLIIFHSPSLRAPMFLLIGSLALADLLAGLGLIINFVFAYLLQSEATKLVTIGLIVASFSASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDESTCSVVRPLTKNNAAILSISFLFMFALMLQLYIQICKIVMRHAHQIALQHHFLATSHYVTTRKGVSTLALILGTFAACWMPFTLYSLIADYTYPSIYTYATLLPATYNSIINPVIYAFRNQEIQKALCLICCGCIPSSLSQRARSPSDV
uniprot
proteins
function
FUNCTION: Brain-specific G protein-coupled receptor involved in regulating diverse physiological processes including neurite outgrowth, meiotic arrest, and lipid and carbohydrate metabolism (PubMed:16229830, PubMed:16887097). Functions as a receptor with constitutive G(s)-mediated signaling activity that stimulates cyclic AMP (cAMP) production. Also engages the G(i)/G(o) pathway, which counteracts the cAMP increase driven by G(s) activation. Additionally, two lipids sphingosylphosphorylcholine (SPC) and sphingosine-1-phosphate (S1P) may act as endogenous ligand and activate GPR12 (PubMed:12574419). {ECO:0000269|PubMed:12574419, ECO:0000269|PubMed:16229830, ECO:0000269|PubMed:16887097}.
uniprot
proteins
mass_dalton
36589
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12574419
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16229830
uniprot
proteins
pubmed
16887097
uniprot
proteins
pubmed
8262253
uniprot
proteins
sequence_length
334
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 49..71; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P47775"; TRANSMEM 78..103; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P47775"; TRANSMEM 114..136; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P47775"; TRANSMEM 154..176; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P47775"; TRANSMEM 193..217; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P47775"; TRANSMEM 252..274; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P47775"; TRANSMEM 281..303; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P47775
uniprot
proteins