RPL13A
entrez
23521
canonical
uniprot
P40429
canonical
ensembl
ENSG00000142541
resolver
ensp
ENSP00000375730
resolver
ensp
ENSP00000477755
resolver
enst
ENST00000391857
resolver
enst
ENST00000621674
resolver
genesymbol
RPL13A
resolver
genesymbol
RPL13a
resolver
genesymbol_syn
RPL13A
resolver
hgnc
HGNC:10304
resolver
uniprot
A0A087WTC4
resolver
uniprot
A0A384ME37
resolver
uniprot
A8K505
resolver
uniprot
Q8J015
resolver
uniprot_entry
A0A087WTC4_HUMAN
resolver
uniprot_entry
A0A384ME37_HUMAN
resolver
uniprot_entry
Q8J015_HUMAN
resolver
uniprot_entry
RL13A_HUMAN
resolver
uniprot_sec
A8K505
resolver
amino_acid_sequence
MAEVQVLVLDGRGHLLGRLAAIVAKQVLLGRKVVVVRCEGINISGNFYRNKLKYLAFLRKRMNTNPSRGPYHFRAPSRIFWRTVRGMLPHKTKRGQAALDRLKVFDGIPPPYDKKKRMVVPAALKVVRLKPTRKFAYLGRLAHEVGWKYQAVTATLEEKRKEKAKIHYRKKKQLMRLRKQAEKNVEKKIDKYTEVLKTHGLLV
uniprot
proteins
function
FUNCTION: Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions (PubMed:14567916, PubMed:17218275, PubMed:23636399, PubMed:32669547). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (PubMed:23071094). In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex (PubMed:23071094). Involved in methylation of rRNA (PubMed:17921318). {ECO:0000269|PubMed:14567916, ECO:0000269|PubMed:17218275, ECO:0000269|PubMed:17921318, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:23636399, ECO:0000269|PubMed:32669547}.
uniprot
proteins
mass_dalton
23577
uniprot
proteins
mutagenesis
MUTAGEN 77; /note="S->A: Loss of interferon-gamma induced phosphorylation."; /evidence="ECO:0000269|PubMed:18995835
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-77 upon interferon-gamma treatment in monocytes involves a DAPK1-DAPK3 kinase cascade and is causing release from the ribosome, association with the GAIT complex and subsequent involvement in transcript-selective translation inhibition. {ECO:0000269|PubMed:14567916, ECO:0000269|PubMed:18995835}.; PTM: Citrullinated by PADI4. {ECO:0000250|UniProtKB:P19253}.
uniprot
proteins
protein_family
Universal ribosomal protein uL13 family
uniprot
proteins
pubmed
10580157
uniprot
proteins
pubmed
1282492
uniprot
proteins
pubmed
12962325
uniprot
proteins
pubmed
14567916
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15479637
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17218275
uniprot
proteins
pubmed
17921318
uniprot
proteins
pubmed
18995835
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23071094
uniprot
proteins
pubmed
23636399
uniprot
proteins
pubmed
24524803
uniprot
proteins
pubmed
25489052
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
32669547
uniprot
proteins
sequence_length
203
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23636399, ECO:0000305|PubMed:14567916}.
uniprot
proteins