GOPC
entrez
57120
canonical
uniprot
Q9HD26
canonical
ensembl
ENSG00000047932
resolver
ensp
ENSP00000052569
resolver
ensp
ENSP00000357484
resolver
genesymbol
GOPC
resolver
genesymbol_syn
CAL
resolver
genesymbol_syn
FIG
resolver
hgnc
HGNC:17643
resolver
uniprot
A6NM30
resolver
uniprot
Q59FS4
resolver
uniprot
Q969U8
resolver
uniprot_entry
GOPC_HUMAN
resolver
uniprot_sec
A6NM30
resolver
uniprot_sec
Q59FS4
resolver
uniprot_sec
Q969U8
resolver
amino_acid_sequence
MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSADSGTIKAKLSGPSVEELERELEANKKEKMKEAQLEAEVKLLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTDTHENGDLGTASETPLDDGASKLDDLHTLYHKKSY
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving GOPC is found in a glioblastoma multiforme sample. An intra-chromosomal deletion del(6)(q21q21) is responsible for the formation of GOPC-ROS1 chimeric protein which has a constitutive receptor tyrosine kinase activity. {ECO:0000269|PubMed:12661006}.
uniprot
proteins
function
FUNCTION: Plays a role in intracellular protein trafficking and degradation (PubMed:11707463, PubMed:14570915, PubMed:15358775). May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels (By similarity). May also regulate the intracellular trafficking of the ADR1B receptor (PubMed:15358775). May play a role in autophagy (By similarity). Together with MARCHF2 mediates the ubiquitination and lysosomal degradation of CFTR (PubMed:23818989). Overexpression results in CFTR intracellular retention and lysosomaldegradation in the lysosomes (PubMed:11707463, PubMed:14570915). {ECO:0000250|UniProtKB:Q8BH60, ECO:0000269|PubMed:11707463, ECO:0000269|PubMed:14570915, ECO:0000269|PubMed:15358775, ECO:0000269|PubMed:23818989}.
uniprot
proteins
mass_dalton
50520
uniprot
proteins
mutagenesis
MUTAGEN 175; /note="L->V: No effect on subcellular location; when associated with V-182; V-189 and V-196."; /evidence="ECO:0000269|PubMed:11384996"; MUTAGEN 182; /note="L->V: No effect on subcellular location; when associated with V-175; V-189 and V-196."; /evidence="ECO:0000269|PubMed:11384996"; MUTAGEN 189; /note="L->V: No effect on subcellular location; when associated with V-175; V-182 and V-196."; /evidence="ECO:0000269|PubMed:11384996"; MUTAGEN 196; /note="L->V: No effect on subcellular location; when associated with V-175; V-182 and V-189."; /evidence="ECO:0000269|PubMed:11384996"; MUTAGEN 216..404; /note="Missing: Abolishes interaction with MARCHF2."; /evidence="ECO:0000269|PubMed:23818989
uniprot
proteins
pubmed
11162552
uniprot
proteins
pubmed
11384996
uniprot
proteins
pubmed
11707463
uniprot
proteins
pubmed
12661006
uniprot
proteins
pubmed
14570915
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15317815
uniprot
proteins
pubmed
15358775
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15546864
uniprot
proteins
pubmed
15951434
uniprot
proteins
pubmed
16882988
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23818989
uniprot
proteins
pubmed
36511702
uniprot
proteins
pubmed
36946756
uniprot
proteins
sequence_length
462
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus membrane {ECO:0000269|PubMed:23818989}; Peripheral membrane protein. Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Synapse {ECO:0000250}. Postsynaptic density {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=Enriched in synaptosomal and postsynaptic densities (PSD) fractions. Expressed in cell bodies and dendrites of Purkinje cells. Localized at the trans-Golgi network (TGN) of spermatids and the medulla of round spermatides. {ECO:0000250}.
uniprot
proteins