Kit
entrez
16590
canonical
uniprot
P05532
canonical
ensembl
ENSMUSG00000005672
resolver
ensp
ENSMUSP00000005815
resolver
ensp
ENSMUSP00000116465
resolver
genesymbol
Kit
resolver
genesymbol_syn
Sl
resolver
uniprot
Q61415
resolver
uniprot
Q61416
resolver
uniprot
Q61417
resolver
uniprot
Q6LEE9
resolver
uniprot
Q6QJB7
resolver
uniprot
Q6QJB8
resolver
uniprot
Q7TS86
resolver
uniprot
Q8C8K9
resolver
uniprot_entry
KIT_MOUSE
resolver
uniprot_sec
Q61415
resolver
uniprot_sec
Q61416
resolver
uniprot_sec
Q61417
resolver
uniprot_sec
Q6LEE9
resolver
uniprot_sec
Q6QJB7
resolver
uniprot_sec
Q6QJB8
resolver
uniprot_sec
Q7TS86
resolver
uniprot_sec
Q8C8K9
resolver
activity_regulation
ACTIVITY REGULATION: Present in an inactive conformation in the absence of bound ligand. KITLG/SCF binding leads to dimerization and activation by autophosphorylation.
uniprot
proteins
amino_acid_sequence
MRGARGAWDLLCVLLVLLRGQTATSQPSASPGEPSPPSIHPAQSELIVEAGDTLSLTCIDPDFVRWTFKTYFNEMVENKKNEWIQEKAEATRTGTYTCSNSNGLTSSIYVFVRDPAKLFLVGLPLFGKEDSDALVRCPLTDPQVSNYSLIECDGKSLPTDLTFVPNPKAGITIKNVKRAYHRLCVRCAAQRDGTWLHSDKFTLKVRAAIKAIPVVSVPETSHLLKKGDTFTVVCTIKDVSTSVNSMWLKMNPQPQHIAQVKHNSWHRGDFNYERQETLTISSARVDDSGVFMCYANNTFGSANVTTTLKVVEKGFINISPVKNTTVFVTDGENVDLVVEYEAYPKPEHQQWIYMNRTSANKGKDYVKSDNKSNIRYVNQLRLTRLKGTEGGTYTFLVSNSDASASVTFNVYVNTKPEILTYDRLINGMLQCVAEGFPEPTIDWYFCTGAEQRCTTPVSPVDVQVQNVSVSPFGKLVVQSSIDSSVFRHNGTVECKASNDVGKSSAFFNFAFKGNNKEQIQAHTLFTPLLIGFVVAAGAMGIIVMVLTYKYLQKPMYEVQWKVVEEINGNNYVYIDPTQLPYDHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTVGGPTLVITEYCCYGDLLNFLRRKRDSFIFSKQEEQAEAALYKNLLHSTEPSCDSSNEYMDMKPGVSYVVPTKTDKRRSARIDSYIERDVTPAIMEDDELALDLDDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIRNDSNYVVKGNARLPVKWMAPESIFSCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMVSPEHAPAEMYDVMKTCWDADPLKRPTFKQVVQLIEKQISDSTKHIYSNLANCNPNPENPVVVDHSVRVNSVGSSASSTQPLLVHEDA
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Kit are the cause of the white-spotting phenotype (W). White-spotting variants induces severe effects on pigmentation, gametogenesis and hematopoiesis. Mice homozygous for W42 die perinatally of macrocytic anemia. {ECO:0000269|PubMed:1688471, ECO:0000269|PubMed:1693331}.
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Tyrosine-protein kinase that acts as a cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1. {ECO:0000269|PubMed:1698611, ECO:0000269|PubMed:1714377, ECO:0000269|PubMed:18725415, ECO:0000269|PubMed:21037083, ECO:0000269|PubMed:7509796, ECO:0000269|PubMed:9528781, ECO:0000269|PubMed:9722617}.
uniprot
proteins
mass_dalton
109343
uniprot
proteins
mutagenesis
MUTAGEN 571; /note="Y->F: Abolishes interaction with PTPN11/SHP-2."; /evidence="ECO:0000269|PubMed:9528781"; MUTAGEN 573; /note="Y->F: Abolishes interaction with PTPN6/SHP-1."; /evidence="ECO:0000269|PubMed:9528781"; MUTAGEN 573; /note="Missing: Abolishes interaction with PTPN6/SHP-1."; /evidence="ECO:0000269|PubMed:9528781"; MUTAGEN 723; /note="Y->F: Abolishes interaction with PIK3R1."; /evidence="ECO:0000269|PubMed:7527401"; MUTAGEN 860; /note="F->S: Mice display white fur, hearing loss, anemia and mast cell deficiency, plus sterility in both males and females."; /evidence="ECO:0000269|PubMed:15731517
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by SOCS6. KIT is rapidly ubiquitinated after autophosphorylation induced by KITLG/SCF binding, leading to internalization and degradation (By similarity). {ECO:0000250}.; PTM: Autophosphorylated on tyrosine residues. KITLG/SCF binding promotes autophosphorylation of isoform 1 and isoform 2. Isoform 1 shows low levels of tyrosine phosphorylation in the absence of added KITLG/SCF, while isoform 2 requires stimulation by KITLG/SCF for phosphorylation (in vitro). Phosphorylation of Tyr-573 is required for interaction with PTPN6/SHP-1. Phosphorylation of Tyr-571 is required for interaction with PTPN11/SHP-2. Phosphorylated tyrosine residues are important for interaction with specific binding partners. {ECO:0000269|PubMed:1714377, ECO:0000269|PubMed:7527401}.
uniprot
proteins
protein_family
CSF-1/PDGF receptor subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
12558531
uniprot
proteins
pubmed
1378413
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15731517
uniprot
proteins
pubmed
1688471
uniprot
proteins
pubmed
1693331
uniprot
proteins
pubmed
1698611
uniprot
proteins
pubmed
1709486
uniprot
proteins
pubmed
1714377
uniprot
proteins
pubmed
17255936
uniprot
proteins
pubmed
17595334
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
18447649
uniprot
proteins
pubmed
18725415
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20200353
uniprot
proteins
pubmed
21037083
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2456920
uniprot
proteins
pubmed
7509796
uniprot
proteins
pubmed
7527401
uniprot
proteins
pubmed
7682073
uniprot
proteins
pubmed
9528781
uniprot
proteins
pubmed
9722617
uniprot
proteins
sequence_length
979
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. Note=Detected in the cytoplasm of spermatozoa, especially in the equatorial and subacrosomal region of the sperm head. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 528..548; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins