Fadd
entrez
14082
canonical
uniprot
Q61160
canonical
ensembl
ENSMUSG00000031077
resolver
ensp
ENSMUSP00000033394
resolver
enst
ENSMUST00000033394
resolver
genesymbol
Fadd
resolver
genesymbol_syn
Mort1
resolver
uniprot
Q3TC37
resolver
uniprot
Q61082
resolver
uniprot_entry
FADD_MOUSE
resolver
uniprot_sec
Q3TC37
resolver
uniprot_sec
Q61082
resolver
amino_acid_sequence
MDPFLVLLHSLSGSLSGNDLMELKFLCRERVSKRKLERVQSGLDLFTVLLEQNDLERGHTGLLRELLASLRRHDLLQRLDDFEAGTATAAPPGEADLQVAFDIVCDNVGRDWKRLARELKVSEAKMDGIEEKYPRSLSERVRESLKVWKNAEKKNASVAGLVKALRTCRLNLVADLVEEAQESVSKSENMSPVLRDSTVSSSETP
uniprot
proteins
function
FUNCTION: Apoptotic adapter molecule that recruits caspases CASP8 or CASP10 to the activated FAS/CD95 or TNFRSF1A/TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. Active CASP8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. {ECO:0000250|UniProtKB:Q13158}.
uniprot
proteins
mass_dalton
22960
uniprot
proteins
pubmed
10347191
uniprot
proteins
pubmed
15383280
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28842570
uniprot
proteins
pubmed
29440439
uniprot
proteins
pubmed
30185824
uniprot
proteins
pubmed
31519887
uniprot
proteins
pubmed
34471287
uniprot
proteins
pubmed
8565075
uniprot
proteins
pubmed
8649383
uniprot
proteins
sequence_length
205
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q13158}.
uniprot
proteins