COL8A1
entrez
1295
canonical
uniprot
P27658
canonical
ensembl
ENSG00000144810
resolver
ensp
ENSP00000261037
resolver
ensp
ENSP00000273342
resolver
ensp
ENSP00000498483
resolver
ensp
ENSP00000565812
resolver
ensp
ENSP00000565813
resolver
ensp
ENSP00000565814
resolver
ensp
ENSP00000565816
resolver
ensp
ENSP00000565817
resolver
ensp
ENSP00000565818
resolver
ensp
ENSP00000565820
resolver
ensp
ENSP00000565821
resolver
ensp
ENSP00000565823
resolver
ensp
ENSP00000565825
resolver
ensp
ENSP00000565826
resolver
ensp
ENSP00000565828
resolver
ensp
ENSP00000565829
resolver
ensp
ENSP00000565831
resolver
ensp
ENSP00000565832
resolver
ensp
ENSP00000565833
resolver
ensp
ENSP00000565834
resolver
ensp
ENSP00000639038
resolver
ensp
ENSP00000639039
resolver
ensp
ENSP00000639040
resolver
ensp
ENSP00000639043
resolver
ensp
ENSP00000639044
resolver
ensp
ENSP00000639045
resolver
ensp
ENSP00000639046
resolver
ensp
ENSP00000639047
resolver
ensp
ENSP00000639048
resolver
ensp
ENSP00000639049
resolver
enst
ENST00000261037
resolver
enst
ENST00000273342
resolver
enst
ENST00000652472
resolver
enst
ENST00000895753
resolver
enst
ENST00000895754
resolver
enst
ENST00000895755
resolver
enst
ENST00000895757
resolver
enst
ENST00000895758
resolver
enst
ENST00000895759
resolver
enst
ENST00000895761
resolver
enst
ENST00000895762
resolver
enst
ENST00000895764
resolver
enst
ENST00000895766
resolver
enst
ENST00000895767
resolver
enst
ENST00000895769
resolver
enst
ENST00000895770
resolver
enst
ENST00000895772
resolver
enst
ENST00000895773
resolver
enst
ENST00000895774
resolver
enst
ENST00000895775
resolver
enst
ENST00000968979
resolver
enst
ENST00000968980
resolver
enst
ENST00000968981
resolver
enst
ENST00000968984
resolver
enst
ENST00000968985
resolver
enst
ENST00000968986
resolver
enst
ENST00000968987
resolver
enst
ENST00000968988
resolver
enst
ENST00000968989
resolver
enst
ENST00000968990
resolver
genesymbol
COL8A1
resolver
genesymbol_syn
C3orf7
resolver
hgnc
HGNC:2215
resolver
uniprot
D3DN42
resolver
uniprot
Q53XI6
resolver
uniprot
Q96D07
resolver
uniprot_entry
CO8A1_HUMAN
resolver
uniprot_sec
D3DN42
resolver
uniprot_sec
Q53XI6
resolver
uniprot_sec
Q96D07
resolver
amino_acid_sequence
MAVLPGPLQLLGVLLTISLSSIRLIQAGAYYGIKPLPPQIPPQMPPQIPQYQPLGQQVPHMPLAKDGLAMGKEMPHLQYGKEYPHLPQYMKEIQPAPRMGKEAVPKKGKEIPLASLRGEQGPRGEPGPRGPPGPPGLPGHGIPGIKGKPGPQGYPGVGKPGMPGMPGKPGAMGMPGAKGEIGQKGEIGPMGIPGPQGPPGPHGLPGIGKPGGPGLPGQPGPKGDRGPKGLPGPQGLRGPKGDKGFGMPGAPGVKGPPGMHGPPGPVGLPGVGKPGVTGFPGPQGPLGKPGAPGEPGPQGPIGVPGVQGPPGIPGIGKPGQDGIPGQPGFPGGKGEQGLPGLPGPPGLPGIGKPGFPGPKGDRGMGGVPGALGPRGEKGPIGAPGIGGPPGEPGLPGIPGPMGPPGAIGFPGPKGEGGIVGPQGPPGPKGEPGLQGFPGKPGFLGEVGPPGMRGLPGPIGPKGEAGQKGVPGLPGVPGLLGPKGEPGIPGDQGLQGPPGIPGIGGPSGPIGPPGIPGPKGEPGLPGPPGFPGIGKPGVAGLHGPPGKPGALGPQGQPGLPGPPGPPGPPGPPAVMPPTPPPQGEYLPDMGLGIDGVKPPHAYGAKKGKNGGPAYEMPAFTAELTAPFPPVGAPVKFNKLLYNGRQNYNPQTGIFTCEVPGVYYFAYHVHCKGGNVWVALFKNNEPVMYTYDEYKKGFLDQASGSAVLLLRPGDRVFLQMPSEQAAGLYAGQYVHSSFSGYLLYPM
uniprot
proteins
function
FUNCTION: Macromolecular component of the subendothelium. Major component of the Descemet's membrane (basement membrane) of corneal endothelial cells. Also a component of the endothelia of blood vessels. Necessary for migration and proliferation of vascular smooth muscle cells and thus, has a potential role in the maintenance of vessel wall integrity and structure, in particular in atherogenesis. {ECO:0000269|PubMed:11708810}.; FUNCTION: Vastatin, the C-terminal fragment comprising the NC1 domain, inhibits aortic endothelial cell proliferation and causes cell apoptosis. {ECO:0000269|PubMed:11708810}.
uniprot
proteins
mass_dalton
73364
uniprot
proteins
post_translational_modification
PTM: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.; PTM: Proteolytically cleaved by neutrophil elastase, in vitro. Proteolytic processing produces the C-terminal NC1 domain fragment, vastatin. {ECO:0000269|PubMed:1515454}.
uniprot
proteins
pubmed
10686422
uniprot
proteins
pubmed
11708810
uniprot
proteins
pubmed
14990571
uniprot
proteins
pubmed
1515454
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17888087
uniprot
proteins
pubmed
2029894
uniprot
proteins
pubmed
2376131
uniprot
proteins
pubmed
7734329
uniprot
proteins
sequence_length
744
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane.
uniprot
proteins