Srd5a3
entrez
57357
canonical
uniprot
Q9WUP4
canonical
ensembl
ENSMUSG00000029233
resolver
ensp
ENSMUSP00000031143
resolver
ensp
ENSMUSP00000109134
resolver
genesymbol
Srd5a3
resolver
genesymbol_syn
Srd5a2l
resolver
uniprot
D3YZB6
resolver
uniprot
D3Z3J5
resolver
uniprot
Q3UU82
resolver
uniprot
Q8BGE3
resolver
uniprot_entry
SR5A3_MOUSE
resolver
uniprot_sec
D3YZB6
resolver
uniprot_sec
D3Z3J5
resolver
uniprot_sec
Q3UU82
resolver
uniprot_sec
Q8BGE3
resolver
amino_acid_sequence
MAGWAGFELSALNPLRTLWLALAAAFLFALLLQLAPARLLPSCALFQDLLRYGKTKQSGSRRPAVCRAFDVPKRYFSHFYVISVVWNGSLLWLLSQSLFLGAPFPNWLSALLRTLGATQFQALEMESKASRMPAAELALSAFLVLVFLWVHSLRRLFECFYVSVFSNAAIHVVQYCFGLVYYVLVGLTVLSQVPMDDKNVYVLGKNLLIQARWFHILGMVMFFWSSAHQYKCHVILSNLRRNKKGVVIHCQHRIPFGDWFEYVSSANYLAELMIYISMAVTFGLHNLTWWLVVTYVFSSQALSAFFNHKFYRSTFVSYPKHRKAFLPFLF
uniprot
proteins
ec_number
1.3.1.22
uniprot
proteins
ec_number
1.3.1.94
uniprot
proteins
function
FUNCTION: Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol (PubMed:20637498). Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism (By similarity). Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation (PubMed:20637498). Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT) (By similarity). {ECO:0000250|UniProtKB:Q9H8P0, ECO:0000269|PubMed:20637498}.
uniprot
proteins
mass_dalton
37936
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:20637498}.
uniprot
proteins
protein_family
Polyprenal reductase subfamily
uniprot
proteins
protein_family
Steroid 5-alpha reductase family
uniprot
proteins
pubmed
11116088
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20637498
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
330
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q5RJM1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5RJM1}.
uniprot
proteins
transmembrane_region
TRANSMEM 17..37; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 81..101; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 133..153; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 170..190; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 207..227; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 278..298; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins