BEX4
entrez
56271
canonical
uniprot
Q9NWD9
canonical
ensembl
ENSG00000102409
resolver
ensp
ENSP00000361776
resolver
ensp
ENSP00000361780
resolver
ensp
ENSP00000576487
resolver
ensp
ENSP00000576488
resolver
ensp
ENSP00000576489
resolver
ensp
ENSP00000576490
resolver
ensp
ENSP00000576491
resolver
ensp
ENSP00000604136
resolver
ensp
ENSP00000604137
resolver
ensp
ENSP00000604138
resolver
ensp
ENSP00000604139
resolver
ensp
ENSP00000604140
resolver
ensp
ENSP00000604141
resolver
ensp
ENSP00000604142
resolver
ensp
ENSP00000604143
resolver
ensp
ENSP00000604144
resolver
ensp
ENSP00000604145
resolver
ensp
ENSP00000632134
resolver
enst
ENST00000372691
resolver
enst
ENST00000372695
resolver
enst
ENST00000906428
resolver
enst
ENST00000906429
resolver
enst
ENST00000906430
resolver
enst
ENST00000906431
resolver
enst
ENST00000906432
resolver
enst
ENST00000934077
resolver
enst
ENST00000934078
resolver
enst
ENST00000934079
resolver
enst
ENST00000934080
resolver
enst
ENST00000934081
resolver
enst
ENST00000934082
resolver
enst
ENST00000934083
resolver
enst
ENST00000934084
resolver
enst
ENST00000934085
resolver
enst
ENST00000934086
resolver
enst
ENST00000962075
resolver
genesymbol
BEX4
resolver
genesymbol_syn
BEXL1
resolver
genesymbol_syn
NADE3
resolver
hgnc
HGNC:25475
resolver
uniprot_entry
BEX4_HUMAN
resolver
amino_acid_sequence
MESKEELAANNLNGENAQQENEGGEQAPTQNEEESRHLGGGEGQKPGGNIRRGRVRRLVPNFRWAIPNRHIEHNEARDDVERFVGQMMEIKRKTREQQMRHYMRFQTPEPDNHYDFCLIP
uniprot
proteins
function
FUNCTION: May play a role in microtubule deacetylation by negatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate in the control of cell cycle progression and genomic stability (PubMed:27512957). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity). {ECO:0000250|UniProtKB:Q9CWT2, ECO:0000269|PubMed:27512957}.
uniprot
proteins
mass_dalton
14067
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated and degraded by the proteasome. {ECO:0000250|UniProtKB:Q3MKP9}.
uniprot
proteins
protein_family
BEX family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
15958283
uniprot
proteins
pubmed
27512957
uniprot
proteins
sequence_length
120
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:27512957}. Nucleus {ECO:0000269|PubMed:27512957}. Cytoplasm {ECO:0000269|PubMed:27512957}. Note=Also localizes to microtubules. {ECO:0000269|PubMed:27512957}.
uniprot
proteins