Slc22a24
entrez
286961
canonical
uniprot
Q76M99
canonical
ensembl
ENSRNOG00000056396
resolver
ensembl
ENSRNOG00055023422
resolver
ensembl
ENSRNOG00060033003
resolver
ensembl
ENSRNOG00065032327
resolver
ensp
ENSRNOP00000085742
resolver
ensp
ENSRNOP00055032688
resolver
ensp
ENSRNOP00060047338
resolver
ensp
ENSRNOP00065045816
resolver
enst
ENSRNOT00000091992
resolver
enst
ENSRNOT00055040249
resolver
enst
ENSRNOT00060057259
resolver
enst
ENSRNOT00065055650
resolver
genesymbol
Slc22a24
resolver
genesymbol_syn
Slc22a19
resolver
genesymbol_syn
Slc22a9
resolver
uniprot_entry
S22AO_RAT
resolver
amino_acid_sequence
MAFQDLITQIGCLGRFQILHLIFVLICFILVVPHTVLENFTAAIPSHRCWVPILDNNTMSDNNSRILSQDDLLRISIPMDSNLRPEKCRRYIQPQWDLLHLNGTFSTVTEPDTEPCVDGWVYDQSTFLSTTVTQWDLVCGSQTLNSVAKFIYMTGIFIGHLMGGHLSDKFGRKFIVTCGLLTLAVTETSVAFAPTFLIYCSLRFLTGISSSCIRTNSALLILEWTSPKFQAMVMALIFSAGGIGQVLLGVLAFGIRNWQHLQLAMSVPVFFLLIPTRWLSESARWLIITNKPQEGLKELIKVAHINGIKNSRDVLTLEVVKTTMKDELEAAETKPSPLVLFRTPNLRKRICLLSFVRCVSLISTVGLLINLQYLSNKVFLLQCLYGVVCTPANLLGNFSMNYMGRRTTQIIFMSVMGISILSITFLTQEMQIPRLVLASLGGAISSASLTSTAVLSNELVPTVIRATALGVIGIFGSAGAALSPLLMILMTYSASLPWIIYGVLPILSSLVVLLLPETRNQPLPDSIQDVENKRKSSREVKKDAVAKVTPF
uniprot
proteins
function
FUNCTION: Renal transmembrane organic anion/dicarboxylate exchanger that participates in the reabsorption of conjugated steroids, as well as bile acids, driven by an outward gradient of dicarboxylates such as glutarate or succinate (PubMed:16079298). Transports estrone 3-sulfate and estradiol-17-glucuronide (17beta-estradiol 17-O-(beta-D-glucuronate)), but not androstanediol glucuronide (5alpha-androstane-3alpha,17beta-diol 3-O-(beta-D-glucuronate)), nor taurocholate (PubMed:31553721). Prefers sulfate conjugates of steroids rather than glucuronide conjugates (PubMed:16079298). {ECO:0000269|PubMed:16079298, ECO:0000269|PubMed:31553721}.
uniprot
proteins
mass_dalton
60981
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
16079298
uniprot
proteins
pubmed
31553721
uniprot
proteins
sequence_length
551
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:31553721}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 16..36; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 146..166; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 174..194; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 204..222; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 235..255; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 260..280; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 350..370; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 378..398; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 410..430; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 435..455; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 469..489; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 496..516; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins