Trib1
entrez
211770
canonical
uniprot
Q8K4K4
canonical
ensembl
ENSMUSG00000032501
resolver
ensp
ENSMUSP00000068834
resolver
genesymbol
Trib1
resolver
genesymbol_syn
Trb1
resolver
uniprot
Q8BFS7
resolver
uniprot
Q8BJR9
resolver
uniprot
Q8BZX3
resolver
uniprot
Q91W04
resolver
uniprot_entry
TRIB1_MOUSE
resolver
uniprot_sec
Q8BFS7
resolver
uniprot_sec
Q8BJR9
resolver
uniprot_sec
Q8BZX3
resolver
uniprot_sec
Q91W04
resolver
amino_acid_sequence
MRVGPVRFALSGASQPRGPGLLFPAARGTPAKRLLDTDDAGAVAAKCPRLSECSSPPDYLSPPGSPCSPQPPPSTQGTGGSCVSSPGPSRIADYLLLPLAEREHVSRALCIHTGRELRCKEFPIKHYQDKIRPYIQLPSHSNITGIVEVLLGESKAYVFFEKDFGDMHSYVRSRKRLREEEAARLFKQIVSAVAHCHQSAIVLGDLKLRKFVFSTEERTQLRLESLEDTHIIKGEDDALSDKHGCPAYVSPEILNTTGTYSGKAADVWSLGVMLYTLLVGRYPFHDSDPSALFSKIRRGQFCIPEHVSPKARCLIRSLLRREPSERLTAPQILLHPWFEYVLEPGYVDSEIGTSDQIVPEYQEDSDISSFFC
uniprot
proteins
function
FUNCTION: Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:20410507, PubMed:23515163). Promotes CEBPA degradation and inhibits its function (PubMed:20410507). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (PubMed:23515163, PubMed:24003916). Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (PubMed:23515163). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (By similarity). {ECO:0000250|UniProtKB:Q96RU8, ECO:0000269|PubMed:20410507, ECO:0000269|PubMed:23515163, ECO:0000269|PubMed:24003916}.
uniprot
proteins
mass_dalton
41281
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tribbles subfamily
uniprot
proteins
pubmed
15299019
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20410507
uniprot
proteins
pubmed
23515163
uniprot
proteins
pubmed
24003916
uniprot
proteins
sequence_length
372
uniprot
proteins