Rnf13
entrez
681578
canonical
uniprot
Q66HG0
canonical
ensembl
ENSRNOG00000029209
resolver
ensembl
ENSRNOG00060005225
resolver
ensp
ENSRNOP00000078956
resolver
ensp
ENSRNOP00000093374
resolver
ensp
ENSRNOP00000105152
resolver
ensp
ENSRNOP00060006560
resolver
enst
ENSRNOT00000113295
resolver
enst
ENSRNOT00000118325
resolver
enst
ENSRNOT00060008714
resolver
genesymbol
Rnf13
resolver
uniprot
A0A8I5ZLW1
resolver
uniprot_entry
A0A8I5ZLW1_RAT
resolver
uniprot_entry
RNF13_RAT
resolver
amino_acid_sequence
MLLSIGMLMLSATQVYTILTVQLFAFLNLLPVEADILAYNFENASQTFEDLPARFGYRLPAEGLKGFLINSKPENACEPIVPPPLKDNSSGTFIVLIRRLDCNFDIKVLNAQRAGYKAAIVHNVDSDDLISMGSNDIDILKKIDIPSVFIGESSANSLKDEFTYEKGGHVILVPELSLPLEYYLIPFLIIVGICLILIVIFMITKFVQDRHRNRRNRLRKDQLKKLPVHKFKKGDEYDVCAICLEEYEDGDKLRILPCSHAYHCKCVDPWLTKTKKTCPVCKQKVVPSQGDSDSDTDSSQEENQVSEHTPLLPPSASARTQSFGSLSESHSHHMTESSDYEDDDNEETDSSDADNEITDHSVVVQLQPNGEPDYNIANTV
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that regulates cell proliferation. Involved in apoptosis regulation. Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA. Also involved in protein trafficking and localization. {ECO:0000250|UniProtKB:O43567}.
uniprot
proteins
mass_dalton
42585
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:O43567}.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. {ECO:0000250|UniProtKB:O43567}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
380
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O43567}; Single-pass type I membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000250|UniProtKB:O54965}; Single-pass type I membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:O43567}; Single-pass type I membrane protein {ECO:0000255}. Nucleus inner membrane {ECO:0000250|UniProtKB:O54965}; Single-pass type I membrane protein {ECO:0000255}. Note=Under certain conditions, relocalizes to recycling endosomes and to the inner nuclear membrane. {ECO:0000250|UniProtKB:O54965}.
uniprot
proteins
transmembrane_region
TRANSMEM 183..203; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins