KCNK5
entrez
8645
canonical
uniprot
O95279
canonical
ensembl
ENSG00000164626
resolver
ensp
ENSP00000352527
resolver
ensp
ENSP00000577404
resolver
enst
ENST00000359534
resolver
genesymbol
KCNK5
resolver
genesymbol
KCNK5b
resolver
genesymbol_syn
TASK2
resolver
hgnc
HGNC:6280
resolver
uniprot
A0A0B6VPR3
resolver
uniprot
B2RAQ6
resolver
uniprot
B5TJL2
resolver
uniprot
Q5VV76
resolver
uniprot_entry
A0A0B6VPR3_HUMAN
resolver
uniprot_entry
KCNK5_HUMAN
resolver
uniprot_sec
B2RAQ6
resolver
uniprot_sec
B5TJL2
resolver
uniprot_sec
Q5VV76
resolver
activity_regulation
ACTIVITY REGULATION: The channel conductance is stimulated by extracellular alkaline pH. Inhibited by quinine, quinidine and external acidification. {ECO:0000269|PubMed:36063992, ECO:0000269|PubMed:9812978}.
uniprot
proteins
amino_acid_sequence
MVDRGPLLTSAIIFYLAIGAAIFEVLEEPHWKEAKKNYYTQKLHLLKEFPCLGQEGLDKILEVVSDAAGQGVAITGNQTFNNWNWPNAMIFAATVITTIGYGNVAPKTPAGRLFCVFYGLFGVPLCLTWISALGKFFGGRAKRLGQFLTKRGVSLRKAQITCTVIFIVWGVLVHLVIPPFVFMVTEGWNYIEGLYYSFITISTIGFGDFVAGVNPSANYHALYRYFVELWIYLGLAWLSLFVNWKVSMFVEVHKAIKKRRRRRKESFESSPHSRKALQVKGSTASKDVNIFSFLSKKEETYNDLIKQIGKKAMKTSGGGETGPGPGLGPQGGGLPALPPSLVPLVVYSKNRVPTLEEVSQTLRSKGHVSRSPDEEAVARAPEDSSPAPEVFMNQLDRISEECEPWDAQDYHPLIFQDASITFVNTEAGLSDEETSKSSLEDNLAGEESPQQGAEAKAPLNMGEFPSSSESTFTSTESELSVPYEQLMNEYNKANSPKGT
uniprot
proteins
function
FUNCTION: K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate (PubMed:26919430, PubMed:36063992, PubMed:9812978). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:36063992). {ECO:0000269|PubMed:26919430, ECO:0000269|PubMed:36063992, ECO:0000269|PubMed:9812978}.
uniprot
proteins
mass_dalton
55130
uniprot
proteins
mutagenesis
MUTAGEN 98; /note="T->C: Abolishes voltage-dependent gating. Conducts instantaneous currents with linear current-voltage relationship."; /evidence="ECO:0000269|PubMed:26919430"; MUTAGEN 203; /note="T->C: Abolishes voltage-dependent gating. Conducts instantaneous currents with linear current-voltage relationship."; /evidence="ECO:0000269|PubMed:26919430
uniprot
proteins
protein_family
Two pore domain potassium channel (TC 1.A.1.8) family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18516069
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
26919430
uniprot
proteins
pubmed
36063992
uniprot
proteins
pubmed
9812978
uniprot
proteins
sequence_length
499
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..26; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 113..133; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 158..180; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 230..250; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins