Hepacam2
entrez
101202
canonical
uniprot
Q4VAH7
canonical
ensembl
ENSMUSG00000044156
resolver
ensp
ENSMUSP00000058882
resolver
enst
ENSMUST00000049985
resolver
genesymbol
Hepacam2
resolver
genesymbol_syn
Miki
resolver
uniprot_entry
HECA2_MOUSE
resolver
amino_acid_sequence
MGQDAFMELLRSMVGLSLCKIHLLLIAGSCLGLKVTVPSYTVHGIRGQALYLPVHYGFHTPASDIQIIWLFERSHTMPKYLLGSVNKSVVPDLEYQHKFTMMPPNASLLINPLQFTDEGNYIVKVNIQGNGTLSASQKIQVTVDDPVMKPMVQFHPASGAVEYVGNITLTCQVEGGTRLVYQWRKSGKPISINSSHSFSPQNNTLWIVPVTKEDIGNYTCLVSNPVSEMESDIIMPTIYYGPYGLQVNSDKGLKVGEVFTVDLGEAVLFDCSADSYPPNTYSWIQRSDNTTHVIKHGPHLEVASEKVAQKTADYVCCAYNNITGRRDETRFTVIITSVGLEKLAQRGKSLSPLASITGISLFLIISMCLLFLWKKYQPYKAIRQKLEGRPESEYRKAQTFSGHEDALSDFGIYEFVTFPDASGVSRMSSRSSPASDGVTGQDIHGTIYEVIQHIPEQQQENTE
uniprot
proteins
function
FUNCTION: Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
51421
uniprot
proteins
post_translational_modification
PTM: Poly-ADP-ribosylated (PARsylated) by tankyrase TNKS during late G2 and prophase, leading to translocation to mitotic centrosomes. {ECO:0000250}.; PTM: N-glycosylated. {ECO:0000250}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
463
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:A8MVW5}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:A8MVW5}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:A8MVW5}. Midbody {ECO:0000250|UniProtKB:A8MVW5}. Note=In interphase, localizes to the Golgi apparatus. Localizes to centrosomes and spindles during prophase, prometaphase, and metaphase of mitosis, and to midbodies at telophase. Translocation to mitotic centrosomes is the result of poly-ADP-ribosylation (PARsylation). {ECO:0000250|UniProtKB:A8MVW5}.
uniprot
proteins
transmembrane_region
TRANSMEM 353..373; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins