SIGIRR
entrez
59307
canonical
uniprot
Q6IA17
canonical
ensembl
ENSG00000185187
resolver
ensp
ENSP00000333656
resolver
ensp
ENSP00000380756
resolver
ensp
ENSP00000403104
resolver
ensp
ENSP00000433022
resolver
ensp
ENSP00000433530
resolver
ensp
ENSP00000434164
resolver
ensp
ENSP00000557824
resolver
ensp
ENSP00000557825
resolver
ensp
ENSP00000632995
resolver
ensp
ENSP00000742441
resolver
enst
ENST00000526395
resolver
enst
ENST00000528845
resolver
enst
ENST00000531205
resolver
enst
ENST00000887765
resolver
enst
ENST00000887766
resolver
enst
ENST00000962936
resolver
genesymbol
SIGIRR
resolver
hgnc
HGNC:30575
resolver
uniprot
C9JFX4
resolver
uniprot
H0YDF8
resolver
uniprot
H0YDR5
resolver
uniprot
Q3KQY2
resolver
uniprot
Q6UXI3
resolver
uniprot
Q9H733
resolver
uniprot_entry
C9JFX4_HUMAN
resolver
uniprot_entry
H0YDF8_HUMAN
resolver
uniprot_entry
H0YDR5_HUMAN
resolver
uniprot_entry
SIGIR_HUMAN
resolver
uniprot_sec
Q3KQY2
resolver
uniprot_sec
Q6UXI3
resolver
uniprot_sec
Q9H733
resolver
amino_acid_sequence
MPGVCDRAPDFLSPSEDQVLRPALGSSVALNCTAWVVSGPHCSLPSVQWLKDGLPLGIGGHYSLHEYSWVKANLSEVLVSSVLGVNVTSTEVYGAFTCSIQNISFSSFTLQRAGPTSHVAAVLASLLVLLALLLAALLYVKCRLNVLLWYQDAYGEVEINDGKLYDAYVSYSDCPEDRKFVNFILKPQLERRRGYKLFLDDRDLLPRAEPSADLLVNLSRCRRLIVVLSDAFLSRAWCSHSFREGLCRLLELTRRPIFITFEGQRRDPAHPALRLLRQHRHLVTLLLWRPGSVTPSSDFWKEVQLALPRKVQYRPVEGDPQTQLQDDKDPMLILRGRVPEGRALDSEVDPDPEGDLGVRGPVFGEPSAPPHTSGVSLGESRSSEVDVSDLGSRNYSARTDFYCLVSKDDM
uniprot
proteins
function
FUNCTION: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. {ECO:0000269|PubMed:12925853, ECO:0000269|PubMed:14715412, ECO:0000269|PubMed:15866876, ECO:0000269|PubMed:25963006}.
uniprot
proteins
mass_dalton
45679
uniprot
proteins
protein_family
Interleukin-1 receptor family
uniprot
proteins
pubmed
10346978
uniprot
proteins
pubmed
12925853
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14715412
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15866876
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
21077278
uniprot
proteins
pubmed
21187075
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25963006
uniprot
proteins
sequence_length
410
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 119..139; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins