Osmr
entrez
18414
canonical
uniprot
O70458
canonical
ensembl
ENSMUSG00000022146
resolver
ensp
ENSMUSP00000022746
resolver
ensp
ENSMUSP00000135204
resolver
enst
ENSMUST00000022746
resolver
enst
ENSMUST00000176826
resolver
genesymbol
Osmr
resolver
genesymbol_syn
Osmrb
resolver
uniprot
A0A0R4J268
resolver
uniprot
G3X8V6
resolver
uniprot
O88821
resolver
uniprot
Q3TRK8
resolver
uniprot_entry
A0A0R4J268_MOUSE
resolver
uniprot_entry
G3X8V6_MOUSE
resolver
uniprot_entry
OSMR_MOUSE
resolver
uniprot_entry
Q3TRK8_MOUSE
resolver
uniprot_sec
O88821
resolver
amino_acid_sequence
MAFSVVLHPAFLLAVLSLRASRSEVLEEPLPLTPEIHKVSFQLKLQEVNLEWTVPALTHEELNMIFQIEISRLNISNTIWVENYSTTVKREEAVRWNWTSDIPLECVKHFIRIRALVDDTKSLPQSSWGNWSSWKEVNAKVSVEPDKSLIFPKDKVLEEGSNVTICLMYGQNVYNVSCKLQDEPIHGEQLDSHVSLLKLNNVVFLSDTGTNINCQATKGPKRIFGTVLFVSKVLEEPKNVSCETRDFKTLDCSWEPGVDTTLTWRKQRFQNYTLCESFSKRCEVSNYRNSYTWQITEGSQEMYNFTLTAENQLRKRSVNINFNLTHRVHPKAPQDVTLKIIGATKANMTWKVHSHGNNYTLLCQVKLQYGEVIHEHNVSVHMSANYLFSDLDPDTKYKAFVRCASANHFWKWSDWTQKEFSTPETAPSQALDVWRQVWSENGRRIVTLFWKPLLKSQANGKIISYNIVVENEAKPTESEHYCVWAPALSTNLSLDLQPYKIRITTNNSMGASPESLMVLSNDSGHEEVKEKTIKGIKDAFNISWEPVSGDTMGYVVDWCAHSQDQRCDLQWKNLGPNTTSTTITSDDFKPGVRYNFRIFERSVEHKARLVEKQRGYTQELAPLVNPKVEIPYSTPNSFVLRWPDYDSDFQAGFIKGYLVYVKSKEMQCNQPWERTLLPDNSVLCKYDINGSETKTLTVENLQPESLYEFFVTPYTSAGPGPNETFTKVTTPDARSHMLLQIILPMTLCVLLSIIVCYWKSQWVKEKCYPDIPNPYKSSILSLIKSKKNPHLIMNVKDCIPDVLEVINKAEGSKTQCVGSGKLHIEDVPTKPPIVPTEKDSSGPVPCIFFENFTYDQSAFDSGSHGLIPGPLKDTAHQLGLLAPPNKFQNVLKNDYMKPLVESPTEETSLIYVSQLASPMCGDKDTLATEPPVPVHGSEYKRQMVVPGSLASPSLKEDNSLTSTVLLGQGEQ
uniprot
proteins
function
FUNCTION: Functions as a shared membrane-bound signal-transducing subunit in two distinct receptor complexes, the type II OSM receptor (heterodimer composed of OSMR and IL6ST) and the IL31 receptor complex (heterodimer composed of OSMR and IL31RA) which respectively bind OSM and IL31 (PubMed:9584176, PubMed:9920829). Functionally, OSM signaling via OSMR/IL6ST regulates many processes including cell proliferation, cell differentiation, cytokine production, whereas the IL31 signaling via OSMR/IL31RA is particularly important in skin immunity (By similarity). Mechanistically, in both the OSM-IL6ST/gp130-OSMR and IL31-IL31RA-OSMR complexes, receptor dimerization activates JAK1 and JAK2 (and to a lesser extent TYK2) associated with the intracellular domains of IL6ST/gp130 and OSMR (or IL31RA and OSMR) (PubMed:9584176). These kinases phosphorylate tyrosine residues on IL6ST/gp130 and OSMR (or IL31RA and OSMR), creating docking sites for STAT1, STAT3, and STAT5B, which are then phosphorylated and activated (PubMed:9584176). In addition, the IL31 receptor complex activates the MAPK pathway (MAPK3/ERK1-MAPK1/ERK2) via recruitment of the adapter protein SHC1 (By similarity). {ECO:0000250|UniProtKB:Q99650, ECO:0000269|PubMed:9584176, ECO:0000269|PubMed:9920829}.
uniprot
proteins
mass_dalton
110229
uniprot
proteins
protein_family
Type 2 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
25381841
uniprot
proteins
pubmed
39532904
uniprot
proteins
pubmed
9584176
uniprot
proteins
pubmed
9920829
uniprot
proteins
sequence_length
971
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q99650}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q99650}.
uniprot
proteins
transmembrane_region
TRANSMEM 738..758; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins