PPP1CB
entrez
5500
canonical
uniprot
P62140
canonical
ensembl
ENSG00000213639
resolver
ensp
ENSP00000296122
resolver
ensp
ENSP00000378769
resolver
ensp
ENSP00000398839
resolver
ensp
ENSP00000414918
resolver
ensp
ENSP00000515219
resolver
enst
ENST00000296122
resolver
enst
ENST00000395366
resolver
enst
ENST00000420282
resolver
enst
ENST00000441461
resolver
enst
ENST00000703173
resolver
genesymbol
HEL-S-80p
resolver
genesymbol
PPP1CB
resolver
hgnc
HGNC:9282
resolver
uniprot
B2R5V4
resolver
uniprot
D6W565
resolver
uniprot
P37140
resolver
uniprot
Q5U087
resolver
uniprot
Q6FG45
resolver
uniprot
V9HW04
resolver
uniprot_entry
PP1B_HUMAN
resolver
uniprot_entry
V9HW04_HUMAN
resolver
uniprot_sec
B2R5V4
resolver
uniprot_sec
D6W565
resolver
uniprot_sec
P37140
resolver
uniprot_sec
Q5U087
resolver
uniprot_sec
Q6FG45
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by the toxins okadaic acid, tautomycin and microcystin Leu-Arg (By similarity). The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress. {ECO:0000250, ECO:0000269|PubMed:15705855}.
uniprot
proteins
amino_acid_sequence
MADGELNVDSLITRLLEVRGCRPGKIVQMTEAEVRGLCIKSREIFLSQPILLELEAPLKICGDIHGQYTDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRFNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDTGLLCDLLWSDPDKDVQGWGENDRGVSFTFGADVVSKFLNRHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGGMMSVDETLMCSFQILKPSEKKAKYQYGGLNSGRPVTPPRTANPPKKR
uniprot
proteins
disease_involvement
DISEASE: Noonan syndrome-like disorder with loose anagen hair 2 (NSLH2) [MIM:617506]: A syndrome characterized by Noonan dysmorphic features such as macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck, pectus anomalies, in association with pluckable, sparse, thin and slow-growing hair. {ECO:0000269|PubMed:27264673, ECO:0000269|PubMed:27681385, ECO:0000269|PubMed:27868344, ECO:0000269|PubMed:28211982, ECO:0000269|PubMed:30368668}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.53
uniprot
proteins
function
FUNCTION: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation (PubMed:35768504, PubMed:35831509, PubMed:36175670). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (PubMed:35768504, PubMed:35831509, PubMed:36175670). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (PubMed:35768504, PubMed:36175670). {ECO:0000269|PubMed:20516061, ECO:0000269|PubMed:21712997, ECO:0000269|PubMed:23396208, ECO:0000269|PubMed:35768504, ECO:0000269|PubMed:35831509, ECO:0000269|PubMed:36175670}.
uniprot
proteins
mass_dalton
37187
uniprot
proteins
protein_family
PP-1 subfamily
uniprot
proteins
protein_family
PPP phosphatase family
uniprot
proteins
pubmed
10906760
uniprot
proteins
pubmed
11399775
uniprot
proteins
pubmed
11564868
uniprot
proteins
pubmed
11739654
uniprot
proteins
pubmed
12226088
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15705855
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18586956
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19377461
uniprot
proteins
pubmed
20354225
uniprot
proteins
pubmed
20424263
uniprot
proteins
pubmed
20516061
uniprot
proteins
pubmed
20926688
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21712997
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23396208
uniprot
proteins
pubmed
24336203
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27264673
uniprot
proteins
pubmed
27681385
uniprot
proteins
pubmed
27868344
uniprot
proteins
pubmed
28211982
uniprot
proteins
pubmed
28296156
uniprot
proteins
pubmed
30368668
uniprot
proteins
pubmed
35768504
uniprot
proteins
pubmed
35831509
uniprot
proteins
pubmed
36175670
uniprot
proteins
pubmed
7796987
uniprot
proteins
pubmed
8312365
uniprot
proteins
sequence_length
327
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11739654}. Nucleus {ECO:0000269|PubMed:11739654}. Nucleus, nucleoplasm {ECO:0000269|PubMed:11739654}. Nucleus, nucleolus {ECO:0000269|PubMed:11739654, ECO:0000269|PubMed:20926688}. Note=Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles. {ECO:0000269|PubMed:11739654}.
uniprot
proteins