PTGER4
entrez
5734
canonical
uniprot
P35408
canonical
ensembl
ENSG00000171522
resolver
ensp
ENSP00000302846
resolver
enst
ENST00000302472
resolver
genesymbol
PTGER4
resolver
genesymbol_syn
PTGER2
resolver
hgnc
HGNC:9596
resolver
uniprot
A0PJF5
resolver
uniprot
Q3MJ87
resolver
uniprot_entry
A0PJF5_HUMAN
resolver
uniprot_entry
PE2R4_HUMAN
resolver
uniprot_sec
Q3MJ87
resolver
amino_acid_sequence
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
uniprot
proteins
function
FUNCTION: Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
uniprot
proteins
mass_dalton
53119
uniprot
proteins
post_translational_modification
PTM: Phosphorylation mediates agonist-mediated desensitization by promoting cytoplasmic retention. {ECO:0000269|PubMed:11597569, ECO:0000269|PubMed:14709160}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11597569
uniprot
proteins
pubmed
14709160
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16424369
uniprot
proteins
pubmed
8163486
uniprot
proteins
pubmed
8250933
uniprot
proteins
pubmed
8661119
uniprot
proteins
pubmed
8862514
uniprot
proteins
sequence_length
488
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 20..43; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 56..79; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 97..115; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 136..160; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 185..211; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 268..295; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 313..332; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins