TNFRSF10D
entrez
8793
canonical
uniprot
Q9UBN6
canonical
ensembl
ENSG00000173530
resolver
ensp
ENSP00000310263
resolver
enst
ENST00000312584
resolver
genesymbol
TNFRSF10D
resolver
genesymbol_syn
DCR2
resolver
genesymbol_syn
TRAILR4
resolver
genesymbol_syn
TRUNDD
resolver
hgnc
HGNC:11907
resolver
uniprot
B2R8W0
resolver
uniprot
Q9Y6Q4
resolver
uniprot_entry
TR10D_HUMAN
resolver
uniprot_sec
B2R8W0
resolver
uniprot_sec
Q9Y6Q4
resolver
amino_acid_sequence
MGLWGQSVPTASSARAGRYPGARTASGTRPWLLDPKILKFVVFIVAVLLPVRVDSATIPRQDEVPQQTVAPQQQRRSLKEEECPAGSHRSEYTGACNPCTEGVDYTIASNNLPSCLLCTVCKSGQTNKSSCTTTRDTVCQCEKGSFQDKNSPEMCRTCRTGCPRGMVKVSNCTPRSDIKCKNESAASSTGKTPAAEETVTTILGMLASPYHYLIIIVVLVIILAVVVVGFSCRKKFISYLKGICSGGGGGPERVHRVLFRRRSCPSRVPGAEDNARNETLSNRYLQPTQVSEQEIQGQELAELTGVTVELPEEPQRLLEQAEAEGCQRRRLLVPVNDADSADISTLLDASATLEEGHAKETIQDQLVGSEKLFYEEDEAGSATSCL
uniprot
proteins
function
FUNCTION: Receptor for the cytotoxic ligand TRAIL (PubMed:9430226). Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis (PubMed:9537512). Reports are contradictory with regards to its ability to induce the NF-kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway (PubMed:9382840, PubMed:9430226). {ECO:0000269|PubMed:9382840, ECO:0000269|PubMed:9430226, ECO:0000269|PubMed:9537512}.
uniprot
proteins
mass_dalton
41849
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9382840
uniprot
proteins
pubmed
9430226
uniprot
proteins
pubmed
9537512
uniprot
proteins
sequence_length
386
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 212..232; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins