Cox4i1
entrez
12857
canonical
uniprot
P19783
canonical
ensembl
ENSMUSG00000031818
resolver
ensp
ENSMUSP00000034276
resolver
ensp
ENSMUSP00000138019
resolver
enst
ENSMUST00000034276
resolver
enst
ENSMUST00000181586
resolver
genesymbol
Cox4i1
resolver
genesymbol_syn
Cox4
resolver
genesymbol_syn
Cox4a
resolver
genesymbol_syn
Coxiv
resolver
uniprot
A2RSV8
resolver
uniprot
Q545A9
resolver
uniprot_entry
A2RSV8_MOUSE
resolver
uniprot_entry
COX41_MOUSE
resolver
uniprot_sec
Q545A9
resolver
amino_acid_sequence
MLASRALSLIGKRAISTSVCLRAHGSVVKSEDYAFPTYADRRDYPLPDVAHVTMLSASQKALKEKEKADWSSLSRDEKVQLYRIQFNESFAEMNRGTNEWKTVVGMAMFFIGFTALVLIWEKSYVYGPIPHTFDRDWVAMQTKRMLDMKANPIQGFSAKWDYDKNEWKK
uniprot
proteins
function
FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000269|PubMed:34616041, ECO:0000269|PubMed:38575788}.
uniprot
proteins
mass_dalton
19530
uniprot
proteins
pathway_participation
PATHWAY: Energy metabolism; oxidative phosphorylation. {ECO:0000269|PubMed:34616041, ECO:0000269|PubMed:38575788}.
uniprot
proteins
protein_family
Cytochrome c oxidase IV family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1654830
uniprot
proteins
pubmed
20959514
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2173832
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
32973183
uniprot
proteins
pubmed
34616041
uniprot
proteins
pubmed
37195149
uniprot
proteins
pubmed
38575788
uniprot
proteins
sequence_length
169
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:34616041, ECO:0000269|PubMed:37195149, ECO:0000269|PubMed:38575788}; Single-pass membrane protein {ECO:0000269|PubMed:34616041, ECO:0000269|PubMed:38575788}.
uniprot
proteins
transmembrane_region
TRANSMEM 100..125; /note="Helical"; /evidence="ECO:0000269|PubMed:34616041, ECO:0000269|PubMed:38575788, ECO:0007744|PDB:7O37, ECO:0007744|PDB:7O3C
uniprot
proteins