Polr2m
entrez
192147
canonical
uniprot
Q91XQ4
canonical
ensembl
ENSRNOG00000057676
resolver
ensembl
ENSRNOG00055006744
resolver
ensembl
ENSRNOG00060021587
resolver
ensembl
ENSRNOG00065017544
resolver
ensp
ENSRNOP00000072186
resolver
ensp
ENSRNOP00055008611
resolver
ensp
ENSRNOP00060030828
resolver
ensp
ENSRNOP00065023286
resolver
enst
ENSRNOT00000085843
resolver
enst
ENSRNOT00055011027
resolver
enst
ENSRNOT00060037384
resolver
enst
ENSRNOT00065029340
resolver
genesymbol
Polr2m
resolver
genesymbol_syn
Grinl1a
resolver
uniprot_entry
GRL1A_RAT
resolver
amino_acid_sequence
MCSLPRGFEPPAPEDLGRQSSAELRERLRRQERLLRNEKFICKLPDKGKKISDTIAKLKAAISEREEVRGRTELFHPVSVDCKLRHKATTRVDTDIDKAQNSDLMLDTSSLVPECSSVDIESSKTTSETQGPTHLTHKGNEETLATGCTVNTCPSARITTQDPSSEVNEHLPQHSSQVEEISSSVDSLFITKLQKITIADQTEPSEENTSTENFPGLQSETPKKPHYMKVLEMRAKNPVPPPHKFKTNVLPTQQSDSSSHCHKGQSPASSEEHRRRARQHLDDVTAARLLPLHHLPAQLLSIEESLALQKEQKQNYEEMQAKLAAQKLAERLNIKMQSFNPEGESSGRYREVRDEDDAQSSDEC
uniprot
proteins
function
FUNCTION: Appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. May play a role in the Mediator complex-dependent regulation of transcription activation. Acts as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II. {ECO:0000250|UniProtKB:P0CAP2}.
uniprot
proteins
mass_dalton
40874
uniprot
proteins
post_translational_modification
PTM: Dephosphorylated at Ser-266 by the PNUTS-PP1 complex, promoting RNA polymerase II transcription pause-release. {ECO:0000250|UniProtKB:P0CAP2}.
uniprot
proteins
protein_family
GRINL1 family
uniprot
proteins
pubmed
11474202
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
364
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins