Cadps
entrez
26989
canonical
uniprot
Q62717
canonical
ensembl
ENSRNOG00000008570
resolver
ensp
ENSRNOP00000076873
resolver
ensp
ENSRNOP00000092113
resolver
ensp
ENSRNOP00000093742
resolver
ensp
ENSRNOP00000095354
resolver
enst
ENSRNOT00000098925
resolver
enst
ENSRNOT00000099157
resolver
genesymbol
Cadps
resolver
genesymbol_syn
Caps
resolver
genesymbol_syn
Caps1
resolver
uniprot
A0A8I6AGZ8
resolver
uniprot
A0A8I6B2G7
resolver
uniprot_entry
A0A8I6AGZ8_RAT
resolver
uniprot_entry
A0A8I6B2G7_RAT
resolver
uniprot_entry
CAPS1_RAT
resolver
amino_acid_sequence
MLDPSSSEEESDEILEEESGKEVLGSAASGARLSPSRTNEGSAGSAGMGGSGAGAGVGAGGGGGSGASSGGGAGGLQPSSRAGGGRPSSPSPSVVSEKEKEELERLQKEEEERKKRLQLYVFVMRCIAYPFNAKQPTDMARRPRKISKQQLQTVKDRFQAFLNGETQIVADEAFMNAVQSYYEVFLKSDRVARMVQSGGCSANDSREVFKKHIEKRVRSLPEIDGLSKETVLSSWMAKFDAIYRGEEDPRKQQARMTASAASELILSKEQLYEMFQNILGIKKFEHQLLYNACQLDNPDEQAAQIRRELDGRLQMADQIARERKFPKFVSKEMENMYIEELKSSVNLLMANLESMPVSKGGEFKLQKLKRSHNASIIDMGEESENQLSKSDVLLSFSLEVVIMEVQGLKSLAPNRIVYCTMEVEGGEKLQTDQAEASKPTWGTQGDFSTTHALPAVKVKLFTESTGVLALEDKELGRVILHPTPNSPKQSEWHKMTVSKNCPDQDLKIKLAVRMDKPQNMKHSGYLWTIGKNVWKRWKKRFFVLVQVSQYTFAMCSYREKKAEPQELLQLDGYTVDYTDPQPGLEGGRAFFNAVKEGDTVIFASDDEQDRILWVQAMYRATGQSHKPVPPTQVQKLKPRAETCLSMDAPISQFYADRAQKHGMDEFISSNPCNFDHASLFEMVQRLTLDHRLNDSYSCLGWFSPGQVFVLDEYCARNGVRGCHRHLCYLRDLLERAENGAMIDPTLLHYSFAFCASHVHGNRPDGIGTVTVEEKERFEEIKERLRVLLENQITHFRYCFPFGRPEGALKATLSLLERVLMKDIVTPVPQEEVKTVIRKCLEQAALVNYSRLSEYAKIEENVGRLITPAKKLEDTIRLAELVIEVLQQNEEHHAEAFAWWSDLMVEHAETFLSLFAVDMDAALEVQPPDTWDSFPLFQLLNDFLRTDYNLCNGKFHKHLQDLFAPLVVRYVDLMESSIAQSIHRGFERESWEPVNNGSGTSEDLFWKLDALQTFIRDLHWPEEEFGKHLEQRLKLMASDMIESCVKRTRIAFEVKLQKTSRSTDFRVPQSICTMFNVMVDAKAQSTKLCSMEMGQEHQYHSKIDELIEETVKEMITLLVAKFVTILEGVLAKLSRYDEGTLFSSFLSFTVKAASKYVDVPKPGMDVADAYVTFVRHSQDVLRDKVNEEMYIERLFDQWYNSSMNVICTWLTDRMDLQLHIYQLKTLIRMVKKTYRDFRLQGVLDSTLNSKTYETIRNRLTVEERTASVSEGGGLQGISMKDSDEEDEEDD
uniprot
proteins
function
FUNCTION: Calcium-binding protein involved in exocytosis of vesicles filled with neurotransmitters and neuropeptides. Probably acts upstream of fusion in the biogenesis or maintenance of mature secretory vesicles. Regulates catecholamine loading of DCVs. May specifically mediate the Ca(2+)-dependent exocytosis of large dense-core vesicles (DCVs) and other dense-core vesicles by acting as a PtdIns(4,5)P2-binding protein that acts at prefusion step following ATP-dependent priming and participates in DCVs-membrane fusion. However, it may also participate in small clear synaptic vesicles (SVs) exocytosis and it is unclear whether its function is related to Ca(2+) triggering. {ECO:0000269|PubMed:10792045, ECO:0000269|PubMed:1516133, ECO:0000269|PubMed:15312653, ECO:0000269|PubMed:9162085, ECO:0000269|PubMed:9697858, ECO:0000269|PubMed:9697859}.
uniprot
proteins
mass_dalton
146266
uniprot
proteins
mutagenesis
MUTAGEN 476; /note="G->E: Loss of function."; /evidence="ECO:0000269|PubMed:15312653"; MUTAGEN 531; /note="K->E: No effect."; /evidence="ECO:0000269|PubMed:11927595"; MUTAGEN 537..540; /note="WKKR->SQKE: Affects PtdIns(4,5)P2-binding, plasma membrane-association but not binding to DCVs."; /evidence="ECO:0000269|PubMed:11927595"; MUTAGEN 558..561; /note="REKK->DEEE: Affects PtdIns(4,5)P2-binding, plasma membrane-association but not binding to DCVs."; /evidence="ECO:0000269|PubMed:11927595"; MUTAGEN 561; /note="K->E: Affects PtdIns(4,5)P2-binding, plasma membrane-association but not binding to DCVs."; /evidence="ECO:0000269|PubMed:11927595
uniprot
proteins
pubmed
10792045
uniprot
proteins
pubmed
11927595
uniprot
proteins
pubmed
14530279
uniprot
proteins
pubmed
1516133
uniprot
proteins
pubmed
15312653
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9162085
uniprot
proteins
pubmed
9289490
uniprot
proteins
pubmed
9525942
uniprot
proteins
pubmed
9697858
uniprot
proteins
pubmed
9697859
uniprot
proteins
sequence_length
1289
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Synapse {ECO:0000269|PubMed:10792045, ECO:0000269|PubMed:11927595, ECO:0000269|PubMed:14530279, ECO:0000269|PubMed:1516133, ECO:0000269|PubMed:9697858}. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane {ECO:0000269|PubMed:10792045, ECO:0000269|PubMed:11927595, ECO:0000269|PubMed:9697858}; Peripheral membrane protein {ECO:0000305}. Note=Membrane-associated to vesicles. Strongly enriched in synaptic fractions. Preferentially binds to dense core vesicles but not to synaptic vesicles. Binds phosphoinosides, with a strong selectivity for PtdIns(4,5)P2 over PtdIns(3,4,5)P3. Probably localizes to different vesicles compared to CADPS2. {ECO:0000269|PubMed:10792045, ECO:0000269|PubMed:11927595, ECO:0000269|PubMed:14530279, ECO:0000269|PubMed:1516133, ECO:0000269|PubMed:9697858}.
uniprot
proteins