Fbxo2
entrez
230904
canonical
uniprot
Q80UW2
canonical
ensembl
ENSMUSG00000041556
resolver
ensp
ENSMUSP00000037377
resolver
ensp
ENSMUSP00000238480
resolver
ensp
ENSMUSP00000332593
resolver
enst
ENSMUST00000047951
resolver
genesymbol
Fbxo2
resolver
genesymbol_syn
Fbs1
resolver
genesymbol_syn
Fbx2
resolver
uniprot
Q3USR5
resolver
uniprot
Q8R0D2
resolver
uniprot_entry
FBX2_MOUSE
resolver
uniprot_entry
Q3USR5_MOUSE
resolver
uniprot_sec
Q8R0D2
resolver
amino_acid_sequence
MDGDGDPESVSHPEEASPEEQPEEAGAEASAEEEQLREAEEEEEAEAVEYLAELPEPLLLRVLAELPATELVQACRLVCLRWKELVDGAPLWLLKCQQEGLVPEGSADEERDHWQQFYFLSKRRRNLLRNPCGEEDLEGWSDVEHGGDGWRVEELPGDNGVEFTQDDSVKKYFASSFEWCRKAQVIDLQAEGYWEELLDTTQPAIVVKDWYSGRTDAGSLYELTVRLLSENEDVLAEFATGQVAVPEDGSWMEISHTFIDYGPGVRFVRFEHGGQDSVYWKGWFGARVTNSSVWVEP
uniprot
proteins
function
FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type. {ECO:0000269|PubMed:12140560, ECO:0000269|PubMed:14990996, ECO:0000269|PubMed:15723043, ECO:0000269|PubMed:17215248, ECO:0000269|PubMed:17720138}.
uniprot
proteins
mass_dalton
33676
uniprot
proteins
mutagenesis
MUTAGEN 177; /note="F->A: Abolishes binding of glycoprotein targets."; /evidence="ECO:0000269|PubMed:14990996"; MUTAGEN 279; /note="Y->A: Abolishes binding of glycoprotein targets."; /evidence="ECO:0000269|PubMed:14990996"; MUTAGEN 280; /note="W->A: Abolishes binding of glycoprotein targets. Strongly reduced ubiquitination of glycoprotein targets."; /evidence="ECO:0000269|PubMed:14990996"; MUTAGEN 281; /note="K->A: No effect on carbohydrate binding."; /evidence="ECO:0000269|PubMed:14990996
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
12140560
uniprot
proteins
pubmed
14990996
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15723043
uniprot
proteins
pubmed
17215248
uniprot
proteins
pubmed
17389369
uniprot
proteins
pubmed
17494702
uniprot
proteins
pubmed
17720138
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
297
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Microsome membrane; Peripheral membrane protein; Cytoplasmic side.
uniprot
proteins