HMGCLL1
entrez
54511
canonical
uniprot
Q8TB92
canonical
ensembl
ENSG00000146151
resolver
ensp
ENSP00000274901
resolver
ensp
ENSP00000309737
resolver
ensp
ENSP00000359887
resolver
ensp
ENSP00000381654
resolver
enst
ENST00000370850
resolver
genesymbol
HMGCLL1
resolver
hgnc
HGNC:21359
resolver
uniprot
B1AQ42
resolver
uniprot
B3KNV0
resolver
uniprot
B7Z1S7
resolver
uniprot
B7Z212
resolver
uniprot
F6WQ54
resolver
uniprot
F8W793
resolver
uniprot
O95896
resolver
uniprot
Q6ZSA9
resolver
uniprot_entry
B7Z212_HUMAN
resolver
uniprot_entry
F6WQ54_HUMAN
resolver
uniprot_entry
HMGC2_HUMAN
resolver
uniprot_entry
O95896_HUMAN
resolver
uniprot_sec
B1AQ42
resolver
uniprot_sec
B3KNV0
resolver
uniprot_sec
B7Z1S7
resolver
uniprot_sec
F8W793
resolver
uniprot_sec
Q6ZSA9
resolver
amino_acid_sequence
MGNVPSAVKHCLSYQQLLREHLWIGDSVAGALDPAQTSLLTNLHCFQPDVSGFSVSLAGTVACIHWETSQLSGLPEFVKIVEVGPRDGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQMADHTEVMKGIHQYPGVRYPVLTPNLQGFHHAVAAGATEISVFGAASESFSKKNINCSIEESMGKFEEVVKSARHMNIPARGYVSCALGCPYEGSITPQKVTEVSKRLYGMGCYEISLGDTIGVGTPGSMKRMLESVMKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSAVSGLGGCPYAKGASGNVATEDLIYMLNGLGLNTGVNLYKVMEAGDFICKAVNKTTNSKVAQASFNA
uniprot
proteins
ec_number
4.1.3.4
uniprot
proteins
function
FUNCTION: Non-mitochondrial 3-hydroxy-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis, the products of which support energy production in nonhepatic animal tissues. {ECO:0000269|PubMed:22847177, ECO:0000269|PubMed:22865860}.
uniprot
proteins
mass_dalton
39514
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="G->A: Abolishes myristoylation and induces a subcellular location change."; /evidence="ECO:0000269|PubMed:22865860"; MUTAGEN 86; /note="R->Q: Abolishes catalytic activity."; /evidence="ECO:0000269|PubMed:22847177"; MUTAGEN 237; /note="L->S: Abolishes catalytic activity."; /evidence="ECO:0000269|PubMed:22847177"; MUTAGEN 278; /note="H->R: Abolishes catalytic activity."; /evidence="ECO:0000269|PubMed:22847177
uniprot
proteins
pathway_participation
PATHWAY: Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.
uniprot
proteins
protein_family
HMG-CoA lyase family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22847177
uniprot
proteins
pubmed
22865860
uniprot
proteins
sequence_length
370
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:22847177}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22847177}; Peripheral membrane protein.
uniprot
proteins