Kdm4d
entrez
244694
canonical
uniprot
Q3U2K5
canonical
ensembl
ENSMUSG00000053914
resolver
ensp
ENSMUSP00000061632
resolver
ensp
ENSMUSP00000111311
resolver
enst
ENSMUST00000058796
resolver
genesymbol
Kdm4d
resolver
genesymbol_syn
Jhdm3d
resolver
genesymbol_syn
Jmjd2d
resolver
uniprot
A2CGB5
resolver
uniprot
B8JK34
resolver
uniprot
Q2M1G7
resolver
uniprot
Q8BI19
resolver
uniprot_entry
KDM4D_MOUSE
resolver
uniprot_sec
A2CGB5
resolver
uniprot_sec
B8JK34
resolver
uniprot_sec
Q2M1G7
resolver
uniprot_sec
Q8BI19
resolver
amino_acid_sequence
MKTKSTCAQNPNCSIMIFRPTKEEFNDFDKYIAYMESQGAHRAGLAKVIPPKEWRARQSYDNISNILIATPLQQVVSGQAGVFTQYHKKKKGMTVGEYRELANSKKYQTPPHLDFEDLERKYWKNRLYESPIYGADVSGSLFDGKTQQWNVGHLGTIQDLLEQECGIVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGQPKTWYAVPPEHGRRLERLARELFPGSSQGCQAFLRHKVALISPTVLKENGIPFGRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKVASQCSCGEARVSFSMDAFVRILQPERYELWKRGQDQAVVDHTETMVSTSQELTTRRVTKAPRKTWGLKRLRLRQVSRSLLPIATVSNVPCNMQVCHTSRQPSDVKGDDVQKSDSARASPHPLSLPSSGHMSTRRCSLGRRPCELGAQESSNGAPVKRQLPAGRDDTSPSPELQPQAVSGDLIVDSGLVNPGPQHLMTASEGGLTSDP
uniprot
proteins
ec_number
1.14.11.66
uniprot
proteins
function
FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. {ECO:0000250|UniProtKB:Q6B0I6}.
uniprot
proteins
mass_dalton
57212
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated via 'Lys-63'-linked ubiquitin chains. Deubiquitinated by USP14 with the help of TRIM14 leading to stabilization. {ECO:0000250|UniProtKB:Q6B0I6}.
uniprot
proteins
protein_family
JHDM3 histone demethylase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
510
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537}.
uniprot
proteins