Dusp7
entrez
235584
canonical
uniprot
Q91Z46
canonical
ensembl
ENSMUSG00000053716
resolver
ensp
ENSMUSP00000126984
resolver
genesymbol
Dusp7
resolver
uniprot
E9PVF4
resolver
uniprot
E9QMS8
resolver
uniprot
Q3TY83
resolver
uniprot
Q3USH2
resolver
uniprot_entry
DUS7_MOUSE
resolver
uniprot_entry
Q3TY83_MOUSE
resolver
uniprot_sec
E9PVF4
resolver
uniprot_sec
E9QMS8
resolver
uniprot_sec
Q3USH2
resolver
activity_regulation
ACTIVITY REGULATION: Strongly inhibited by sodium orthovanadate. {ECO:0000250|UniProtKB:Q16829}.
uniprot
proteins
amino_acid_sequence
MKNQLRGPPVRAHMSTSGAAAAAAAGGTRAGSEPGAGSGSGAGIGAGATTGAGAMPCKSAEWLQEELEARGGASLLLLDCRPHELFESSHIETAINLAIPGLMLRRLRKGNLPIRSIIPNHADKERFATRCKAATVLLYDEATAEWQPEPGAPASVLGLLLQKLRDDGCQAYYLQGGFNKFQTEYSEHCETNVDSSSSPSGSPPTSVLGLGGLRISSDCSDGESDRELPSSATESDGSPVPSSQPAFPVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTLGLSSPCDNHAPSEQLYFSTPTNHNLFPINTLEST
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Dual specificity protein phosphatase (PubMed:27783954). Shows high activity towards MAPK1/ERK2 (By similarity). Also has lower activity towards MAPK14 and MAPK8 (By similarity). In arrested oocytes, plays a role in meiotic resumption (PubMed:27783954). Promotes nuclear envelope breakdown and activation of the CDK1/Cyclin-B complex in oocytes, probably by dephosphorylating and inactivating the conventional protein kinase C (cPKC) isozyme PRKCB (PubMed:27783954). May also inactivate PRKCA and/or PRKCG (PubMed:27783954). Also important in oocytes for normal chromosome alignment on the metaphase plate and progression to anaphase, where it might regulate activity of the spindle-assembly checkpoint (SAC) complex (PubMed:27783954). {ECO:0000250|UniProtKB:Q16829, ECO:0000269|PubMed:27783954}.
uniprot
proteins
mass_dalton
45220
uniprot
proteins
mutagenesis
MUTAGEN 105..106; /note="RR->M: Loss of MAPK1 binding. No effect on nuclear envelope breakdown activity in oocytes."; /evidence="ECO:0000269|PubMed:27783954"; MUTAGEN 334; /note="C->S: No effect on MAPK1 binding. Impairs nuclear envelope breakdown activity in oocytes."; /evidence="ECO:0000269|PubMed:27783954
uniprot
proteins
protein_family
Non-receptor class dual specificity subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
27783954
uniprot
proteins
sequence_length
422
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q16829}.
uniprot
proteins