Adh5
entrez
100145871
canonical
uniprot
P12711
canonical
ensembl
ENSRNOG00000089438
resolver
ensp
ENSRNOP00000112328
resolver
enst
ENSRNOT00000139554
resolver
genesymbol
Adh5
resolver
genesymbol_syn
Adh-2
resolver
genesymbol_syn
Adh2
resolver
uniprot
Q5XIF8
resolver
uniprot_entry
ADHX_RAT
resolver
uniprot_sec
Q5XIF8
resolver
amino_acid_sequence
MANQVIRCKAAVAWEAGKPLSIEEIEVAPPQAHEVRIKIIATAVCHTDAYTLSGADPEGCFPVILGHEGAGIVESVGEGVTKLKAGDTVIPLYIPQCGECKFCLNPKTNLCQKIRVTQGKGLMPDGTSRFTCKGKPILHFMGTSTFSEYTVVADISVAKIDPSAPLDKVCLLGCGISTGYGAAVNTAKVEPGSTCAVFGLGGVGLAVIMGCKVAGASRIIGIDINKDKFAKAKEFGATECINPQDFSKSIQEVLIEMTDGGVDFSFECIGNVKVMRSALEAAHKGWGVSVVVGVAASGEEISTRPFQLVTGRTWKGTAFGGWKSVESVPKLVSEYMSKKIKVDEFVTGNLSFDQINKAFDLMHSGNSIRTVLKM
uniprot
proteins
ec_number
1.1.1.-
uniprot
proteins
ec_number
1.1.1.1
uniprot
proteins
ec_number
1.1.1.284
uniprot
proteins
function
FUNCTION: Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage (By similarity). Also acts as a S-nitroso-glutathione reductase by catalyzing the NADH-dependent reduction of S-nitrosoglutathione, thereby regulating protein S-nitrosylation (By similarity). {ECO:0000250|UniProtKB:P11766, ECO:0000250|UniProtKB:P28474}.
uniprot
proteins
mass_dalton
39576
uniprot
proteins
protein_family
Class-III subfamily
uniprot
proteins
protein_family
Zinc-containing alcohol dehydrogenase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1888714
uniprot
proteins
pubmed
3278908
uniprot
proteins
pubmed
3653405
uniprot
proteins
sequence_length
374
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
uniprot
proteins