SRPX2
entrez
27286
canonical
uniprot
O60687
canonical
ensembl
ENSG00000102359
resolver
ensp
ENSP00000362095
resolver
enst
ENST00000373004
resolver
genesymbol
SRPX2
resolver
genesymbol_syn
SRPUL
resolver
hgnc
HGNC:30668
resolver
uniprot
B3KQT3
resolver
uniprot
Q8WW85
resolver
uniprot_entry
SRPX2_HUMAN
resolver
uniprot_sec
B3KQT3
resolver
uniprot_sec
Q8WW85
resolver
amino_acid_sequence
MASQLTQRGALFLLFFLTPAVTPTWYAGSGYYPDESYNEVYAEEVPQAPALDYRVPRWCYTLNIQDGEATCYSPKGGNYHSSLGTRCELSCDRGFRLIGRRSVQCLPSRRWSGTAYCRQMRCHALPFITSGTYTCTNGVLLDSRCDYSCSSGYHLEGDRSRICMEDGRWSGGEPVCVDIDPPKIRCPHSREKMAEPEKLTARVYWDPPLVKDSADGTITRVTLRGPEPGSHFPEGEHVIRYTAYDRAYNRASCKFIVKVQVRRCPTLKPPQHGYLTCTSAGDNYGATCEYHCDGGYDRQGTPSRVCQSSRQWSGSPPICAPMKINVNVNSAAGLLDQFYEKQRLLIISAPDPSNRYYKMQISMLQQSTCGLDLRHVTIIELVGQPPQEVGRIREQQLSANIIEELRQFQRLTRSYFNMVLIDKQGIDRDRYMEPVTPEEIFTFIDDYLLSNQELTQRREQRDICE
uniprot
proteins
disease_involvement
DISEASE: Rolandic epilepsy, impaired intellectual development, and speech dyspraxia, X-linked (RESDX) [MIM:300643]: A condition characterized by the association of rolandic seizures with oral and speech dyspraxia, and intellectual disability. Rolandic seizures occur during a period of significant brain maturation. During this time, dysfunction of neural network activities such as focal discharges may be associated with specific developmental disabilities resulting in specific cognitive impairments of language, visuo-spatial abilities or attention. {ECO:0000269|PubMed:16497722}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. May have a role in the perisylvian region, critical for language and cognitive development. {ECO:0000269|PubMed:16497722, ECO:0000269|PubMed:18718938, ECO:0000269|PubMed:19065654, ECO:0000269|PubMed:24179158}.
uniprot
proteins
mass_dalton
52972
uniprot
proteins
post_translational_modification
PTM: Contains chondroitin sulfate chains. {ECO:0000269|PubMed:22242148}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
16497722
uniprot
proteins
pubmed
18718938
uniprot
proteins
pubmed
19065654
uniprot
proteins
pubmed
22242148
uniprot
proteins
pubmed
24179158
uniprot
proteins
pubmed
9864177
uniprot
proteins
sequence_length
465
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22242148}. Cytoplasm. Cell surface. Synapse {ECO:0000250}.
uniprot
proteins