Slc11a1
entrez
18173
canonical
uniprot
P41251
canonical
ensembl
ENSMUSG00000026177
resolver
ensp
ENSMUSP00000027368
resolver
enst
ENSMUST00000027368
resolver
genesymbol
Slc11a1
resolver
genesymbol_syn
Bcg
resolver
genesymbol_syn
Ity
resolver
genesymbol_syn
Lsh
resolver
genesymbol_syn
Nramp1
resolver
uniprot
Q3TB84
resolver
uniprot_entry
NRAM1_MOUSE
resolver
uniprot_sec
Q3TB84
resolver
amino_acid_sequence
MISDKSPPRLSRPSYGSISSLPGPAPQPAPCRETYLSEKIPIPSADQGTFSLRKLWAFTGPGFLMSIAFLDPGNIESDLQAGAVAGFKLLWVLLWATVLGLLCQRLAARLGVVTGKDLGEVCHLYYPKVPRILLWLTIELAIVGSDMQEVIGTAISFNLLSAGRIPLWDGVLITIVDTFFFLFLDNYGLRKLEAFFGLLITIMALTFGYEYVVAHPSQGALLKGLVLPTCPGCGQPELLQAVGIVGAIIMPHNIYLHSALVKSREVDRTRRVDVREANMYFLIEATIALSVSFIINLFVMAVFGQAFYQQTNEEAFNICANSSLQNYAKIFPRDNNTVSVDIYQGGVILGCLFGPAALYIWAVGLLAAGQSSTMTGTYAGQFVMEGFLKLRWSRFARVLLTRSCAILPTVLVAVFRDLKDLSGLNDLLNVLQSLLLPFAVLPILTFTSMPAVMQEFANGRMSKAITSCIMALVCAINLYFVISYLPSLPHPAYFGLVALFAIGYLGLTAYLAWTCCIAHGATFLTHSSHKHFLYGLPNEEQGGVQGSG
uniprot
proteins
function
FUNCTION: Antiporter that transports metal ions against a proton gradient, and which promotes host resistance to infection against intracellular parasites, such as M.bovis, S.typhimurium and L.donovani (PubMed:11067873, PubMed:11237855, PubMed:31753999, PubMed:8757814). Plays a key role in pathogen resistance in macrophages by mediating the export of metal ions from the phagosomal compartment, thereby limiting the nutrients available to intracellular pathogens and restricting their growth (PubMed:31753999). Also promotes antimicrobial activity in neutrophils against pathogens that survive within phagocytic cells (PubMed:38374245). {ECO:0000269|PubMed:11067873, ECO:0000269|PubMed:11237855, ECO:0000269|PubMed:31753999, ECO:0000269|PubMed:38374245, ECO:0000269|PubMed:8757814}.
uniprot
proteins
mass_dalton
59741
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:15202932}.
uniprot
proteins
protein_family
NRAMP (TC 2.A.55) family
uniprot
proteins
pubmed
11067873
uniprot
proteins
pubmed
11237855
uniprot
proteins
pubmed
15202932
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31753999
uniprot
proteins
pubmed
38374245
uniprot
proteins
pubmed
7513015
uniprot
proteins
pubmed
7665187
uniprot
proteins
pubmed
8490962
uniprot
proteins
pubmed
8757814
uniprot
proteins
pubmed
8871656
uniprot
proteins
pubmed
9034150
uniprot
proteins
pubmed
9730978
uniprot
proteins
sequence_length
548
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:11067873, ECO:0000269|PubMed:9034150, ECO:0000269|PubMed:9730978}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:9034150, ECO:0000269|PubMed:9730978}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:9730978}; Multi-pass membrane protein {ECO:0000255}. Note=After onfection, vesicles migrate to the site of bacterial phagosomes. {ECO:0000269|PubMed:9730978}.
uniprot
proteins
transmembrane_region
TRANSMEM 58..77; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P49279"; TRANSMEM 90..107; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P49279"; TRANSMEM 129..156; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P49279"; TRANSMEM 167..184; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P49279"; TRANSMEM 188..208; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P49279"; TRANSMEM 238..257; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P49279"; TRANSMEM 281..299; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P49279"; TRANSMEM 359..380; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P49279"; TRANSMEM 394..413; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:P49279"; TRANSMEM 424..444; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:P49279"; TRANSMEM 459..480; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:P49279"; TRANSMEM 494..516; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:P49279
uniprot
proteins