Pycr2
entrez
69051
canonical
uniprot
Q922Q4
canonical
ensembl
ENSMUSG00000026520
resolver
ensp
ENSMUSP00000027802
resolver
enst
ENSMUST00000027802
resolver
genesymbol
Pycr2
resolver
uniprot
Q3TMZ1
resolver
uniprot_entry
P5CR2_MOUSE
resolver
uniprot_entry
Q3TMZ1_MOUSE
resolver
amino_acid_sequence
MSVGFIGAGQLACALARGFTAAGVLSAHKIIASSPDMDLPTVSALRRMGVNLTRSNKDTVRHSDVLFLAVKPHIIPFILDEIGADVQERHIVVSCAAGVTISSVEKKLMAFQPAPKVIRCMTNTPVVVREGATVYATGTHALVEDGKLLEQLMSSVGFCTEVEEDLIDAITGLSGSGPAYAFMALDALADGGVKMGVPRRLAVRLGAQALLGAAKMLLDSEDHPGQLKDNVCSPGGATIHALHFLESGGFRSLLINAVEASCIRTRELQSMADQEKVSPAALKKTLLDRVKLESPTVSTLAPPSSGKLLTRNPAQGSKKE
uniprot
proteins
ec_number
1.5.1.2
uniprot
proteins
function
FUNCTION: Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate to L-proline using NAD(P)H. At physiologic concentrations, has higher specific activity in the presence of NADH. Involved in cellular response to oxidative stress. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). {ECO:0000250|UniProtKB:Q96C36}.
uniprot
proteins
mass_dalton
33659
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by UBE4B, leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q96C36}.
uniprot
proteins
protein_family
Pyrroline-5-carboxylate reductase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
320
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96C36}. Mitochondrion {ECO:0000250|UniProtKB:Q96C36}.
uniprot
proteins