Pals1
entrez
56217
canonical
uniprot
Q9JLB2
canonical
ensembl
ENSMUSG00000021112
resolver
ensp
ENSMUSP00000080683
resolver
ensp
ENSMUSP00000290059
resolver
enst
ENSMUST00000082024
resolver
genesymbol
Pals1
resolver
genesymbol_syn
Mpp5
resolver
uniprot
B2RRY4
resolver
uniprot_entry
B2RRY4_MOUSE
resolver
uniprot_entry
PALS1_MOUSE
resolver
amino_acid_sequence
MTTSYMNGHVTEESDSGIKNLDLASPEEYPKHREMAVDCPGDLGTRMMPVRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPIFDTEEGIVLESPHYAVNILDVEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNRDFQNAFKIHNAVTVHMSKASPPFPLIANVQDLVQEVQTVLKPVHQKEGQELTALLNAPHIQALLLAHDKVAEQEMQLEPITDERVYESIGHYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDDYDNEEILTYEEMSLYHQPANRKRPIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRNRRDHEVAGRDYHFVSRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQERLRALLAKEGKNPKPEELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLINKLDTEPQWVPSTWLR
uniprot
proteins
function
FUNCTION: Plays a role in tight junction biogenesis and in the establishment of cell polarity in epithelial cells (By similarity). Also involved in adherens junction biogenesis by ensuring correct localization of the exocyst complex protein EXOC4/SEC8 which allows trafficking of adherens junction structural component CDH1 to the cell surface (PubMed:17182851, PubMed:20237282). Plays a role through its interaction with CDH5 in vascular lumen formation and endothelial membrane polarity (By similarity). Required during embryonic and postnatal retinal development (PubMed:22398208). Required for the maintenance of cerebellar progenitor cells in an undifferentiated proliferative state, preventing premature differentiation, and is required for cerebellar histogenesis, fissure formation, cerebellar layer organization and cortical development (PubMed:20399730, PubMed:26404741). Plays a role in neuronal progenitor cell survival, potentially via promotion of mTOR signaling (PubMed:20399730). Plays a role in the radial and longitudinal extension of the myelin sheath in Schwann cells (PubMed:20237282). May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter (PubMed:15234345). May play a role in the T-cell receptor-mediated activation of NF-kappa-B (By similarity). Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (PubMed:15677456). Required for the normal polarized localization of the vesicular marker STX4 (PubMed:20237282). Required for the correct trafficking of the myelin proteins PMP22 and MAG (By similarity). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (PubMed:21145499). {ECO:0000250|UniProtKB:B4F7E7, ECO:0000250|UniProtKB:Q8N3R9, ECO:0000269|PubMed:15234345, ECO:0000269|PubMed:15677456, ECO:0000269|PubMed:17182851, ECO:0000269|PubMed:20237282, ECO:0000269|PubMed:20399730, ECO:0000269|PubMed:21145499, ECO:0000269|PubMed:22398208, ECO:0000269|PubMed:26404741, ECO:0000269|PubMed:26657772}.
uniprot
proteins
mass_dalton
77229
uniprot
proteins
mutagenesis
MUTAGEN 32; /note="H->A: No effect on interaction with PARD6B."; /evidence="ECO:0000269|PubMed:15140881"; MUTAGEN 33; /note="R->A: No effect on interaction with PARD6B."; /evidence="ECO:0000269|PubMed:15140881"; MUTAGEN 34; /note="E->A: No effect on interaction with PARD6B."; /evidence="ECO:0000269|PubMed:15140881"; MUTAGEN 36; /note="A->G: No effect on interaction with PARD6B."; /evidence="ECO:0000269|PubMed:15140881"; MUTAGEN 37; /note="V->G: Prevents interaction with PARD6B. Does not affect localization to the tight junctions."; /evidence="ECO:0000269|PubMed:15140881"; MUTAGEN 37; /note="V->I: No effect on interaction with PARD6B."; /evidence="ECO:0000269|PubMed:15140881"; MUTAGEN 38; /note="D->A: Prevents interaction with PARD6B."; /evidence="ECO:0000269|PubMed:15140881"; MUTAGEN 38; /note="D->E: No effect on interaction with PARD6B."; /evidence="ECO:0000269|PubMed:15140881"; MUTAGEN 39; /note="C->A: No effect on interaction with PARD6B."; /evidence="ECO:0000269|PubMed:15140881"; MUTAGEN 40; /note="P->A: No effect on interaction with PARD6B."; /evidence="ECO:0000269|PubMed:15140881"; MUTAGEN 150; /note="L->G: No effect on PARD6B interaction. Prevents interaction with PATJ; when associated with G-154."; /evidence="ECO:0000269|PubMed:11927608"; MUTAGEN 154; /note="V->G: No effect on PARD6B interaction. Prevents interaction with PATJ; when associated with G-150."; /evidence="ECO:0000269|PubMed:11927608"; MUTAGEN 207; /note="E->Q: No effect on interaction with LIN7C."; /evidence="ECO:0000269|PubMed:10753959"; MUTAGEN 208; /note="L->G: Prevents interaction with LIN7C."; /evidence="ECO:0000269|PubMed:10753959"; MUTAGEN 212; /note="L->G: Prevents interaction with LIN7C."; /evidence="ECO:0000269|PubMed:10753959"; MUTAGEN 216; /note="H->N: No effect on interaction with LIN7C."; /evidence="ECO:0000269|PubMed:10753959"; MUTAGEN 221; /note="L->G: Partially prevents interaction with LIN7C."; /evidence="ECO:0000269|PubMed:10753959"; MUTAGEN 224; /note="H->N: Partially prevents interaction with LIN7C."; /evidence="ECO:0000269|PubMed:10753959"; MUTAGEN 225; /note="D->N: Prevents interaction with LIN7C."; /evidence="ECO:0000269|PubMed:10753959"; MUTAGEN 227; /note="V->G: Prevents interaction with LIN7C."; /evidence="ECO:0000269|PubMed:10753959"; MUTAGEN 379; /note="L->P: Failure to restore localization of PALS1 and PATJ to cell-cell contacts and to restore tight junction and adherens junction formation in cells where PALS1 has been knocked down."; /evidence="ECO:0000269|PubMed:17182851
uniprot
proteins
protein_family
MAGUK family
uniprot
proteins
pubmed
10753959
uniprot
proteins
pubmed
11927608
uniprot
proteins
pubmed
12527193
uniprot
proteins
pubmed
12545177
uniprot
proteins
pubmed
15140881
uniprot
proteins
pubmed
15234345
uniprot
proteins
pubmed
15241471
uniprot
proteins
pubmed
15316081
uniprot
proteins
pubmed
15558731
uniprot
proteins
pubmed
15677456
uniprot
proteins
pubmed
16519681
uniprot
proteins
pubmed
17182851
uniprot
proteins
pubmed
17920587
uniprot
proteins
pubmed
20237282
uniprot
proteins
pubmed
20399730
uniprot
proteins
pubmed
21145499
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22398208
uniprot
proteins
pubmed
23001562
uniprot
proteins
pubmed
23893895
uniprot
proteins
pubmed
26404741
uniprot
proteins
pubmed
26657772
uniprot
proteins
pubmed
27466317
uniprot
proteins
sequence_length
675
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250|UniProtKB:Q8N3R9}. Cell membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Cell junction, tight junction {ECO:0000269|PubMed:21145499}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q8N3R9}. Cell projection, axon {ECO:0000269|PubMed:15234345}. Perikaryon {ECO:0000269|PubMed:15234345}. Apical cell membrane {ECO:0000269|PubMed:26404741, ECO:0000269|PubMed:26657772}. Note=Localized to the tight junctions of epithelial cells (PubMed:10753959, PubMed:11927608, PubMed:15140881, PubMed:15677456). Localized to the Golgi apparatus in T lymphocytes (By similarity). Localized to a subset of intracellular vesicles (PubMed:15234345). Localized to the Purkinje cell body and axon (PubMed:15234345). Localized to intercellular junctions in vascular endothelial cells (By similarity). Localized to Schmidt-Lanterman incisures, the adaxonal domain, and the inner part of paranodal loops in myelinating Schwann cells of the sciatic nerve (PubMed:20237282). Localized to apical membrane domains of the outer limiting membrane (OLM) junctions in the retina (PubMed:15558731). Colocalizes with CRB1 at the OLM, apical to the adherens junction (By similarity). Colocalizes with MPP1 in the retina at the OLM (By similarity). Colocalizes with MPP3 to the subapical region of adherens junctions in the retina OLM (By similarity). {ECO:0000250|UniProtKB:Q8N3R9, ECO:0000269|PubMed:10753959, ECO:0000269|PubMed:11927608, ECO:0000269|PubMed:15140881, ECO:0000269|PubMed:15234345, ECO:0000269|PubMed:15558731, ECO:0000269|PubMed:15677456, ECO:0000269|PubMed:20237282}.
uniprot
proteins