Abhd6
entrez
66082
canonical
uniprot
Q8R2Y0
canonical
ensembl
ENSMUSG00000025277
resolver
ensp
ENSMUSP00000129169
resolver
ensp
ENSMUSP00000153068
resolver
ensp
ENSMUSP00000250230
resolver
genesymbol
Abhd6
resolver
uniprot
Q3TGD2
resolver
uniprot
Q9D375
resolver
uniprot
Q9DCD4
resolver
uniprot_entry
ABHD6_MOUSE
resolver
uniprot_entry
Q9D375_MOUSE
resolver
uniprot_sec
Q3TGD2
resolver
uniprot_sec
Q9DCD4
resolver
amino_acid_sequence
MDLDVVNMFVIAGGTLAIPILAFVASFLLWPSALIRIYYWYWRRTLGMQVRYAHHEDYQFCYSFRGRPGHKPSILMLHGFSAHKDMWLSVVKFLPKNLHLVCVDMPGHEGTTRSSLDDLSIVGQVKRIHQFVECLKLNKKPFHLIGTSMGGHVAGVYAAYYPSDVCSLSLVCPAGLQYSTDNPFVQRLKELEESAAIQKIPLIPSTPEEMSEMLQLCSYVRFKVPQQILQGLVDVRIPHNSFYRKLFLEIVNEKSRYSLHENMDKIKVPTQIIWGKQDQVLDVSGADILAKSISNSQVEVLENCGHSVVMERPRKTAKLIVDFLASVHNTDNKKLN
uniprot
proteins
ec_number
3.1.1.23
uniprot
proteins
function
FUNCTION: Lipase that preferentially hydrolysis medium-chain saturated monoacylglycerols including 2-arachidonoylglycerol (PubMed:18096503, PubMed:20657592). Through 2-arachidonoylglycerol degradation may regulate endocannabinoid signaling pathways (PubMed:18096503, PubMed:20657592). Also has a lysophosphatidyl lipase activity with a preference for lysophosphatidylglycerol among other lysophospholipids (PubMed:24095738). Also able to degrade bis(monoacylglycero)phosphate (BMP) and constitutes the major enzyme for BMP catabolism (PubMed:26491015). BMP, also known as lysobisphosphatidic acid, is enriched in late endosomes and lysosomes and plays a key role in the formation of intraluminal vesicles and in lipid sorting (PubMed:26491015). {ECO:0000269|PubMed:18096503, ECO:0000269|PubMed:20657592, ECO:0000269|PubMed:24095738, ECO:0000269|PubMed:26491015}.
uniprot
proteins
mass_dalton
38205
uniprot
proteins
mutagenesis
MUTAGEN 148; /note="S->A: Loss of the lipid hydrolase activity."; /evidence="ECO:0000269|PubMed:24095738
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18096503
uniprot
proteins
pubmed
20657592
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24095738
uniprot
proteins
pubmed
26491015
uniprot
proteins
sequence_length
336
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:26491015}; Single-pass type II membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:26491015}; Single-pass type II membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000269|PubMed:20657592}; Single-pass type II membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins