Ido2
entrez
681319
canonical
uniprot
F1LV46
canonical
ensembl
ENSRNOG00000025365
resolver
ensembl
ENSRNOG00060011803
resolver
ensp
ENSRNOP00000036799
resolver
ensp
ENSRNOP00000102049
resolver
ensp
ENSRNOP00060015682
resolver
enst
ENSRNOT00000032116
resolver
enst
ENSRNOT00000149899
resolver
enst
ENSRNOT00060019977
resolver
genesymbol
Ido2
resolver
genesymbol_syn
Indol1
resolver
uniprot
A0A0N4SWI7
resolver
uniprot_entry
A0A0N4SWI7_RAT
resolver
uniprot_entry
I23O2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activity is inhibited by D-1MT (1-methyl-D-tryptophan) and MTH-trp (methylthiohydantoin-DL-tryptophan) but not L-1MT (1-methyl-L-tryptophan). {ECO:0000250|UniProtKB:Q8R0V5}.
uniprot
proteins
amino_acid_sequence
MEAQRQDGKLASSLSLGKYHISEEYGFLLPNPLEELPDHYKPWMEIAHRLPHLIESHQLQAHVYEMPLLDCRFLTSYREQRLAHLVLAAITMGFVWQEGEAQPQKVLPRTLAIPFVEVSRSLGLPPILVHSDLVLTNWTKRNPEGPLEIGNLETIISFPGGESLQGFILVTVLVEKAAVPGIKALVLGVEAIRQHSQDTLLEALQQLRLSIQDITRALAQMHDYVDPEIFYLVIRIFLSGWKDNPVMPVGLVYEGVSTEPLKYSGGSAAQSSVLHAFDEFLGIQHCKESVDFLHRMRDYMPPSHKAFLEDLHSAPSLRDYILDSGPGGCLMAYNQCVEALGELRSYHINMVARYIISAASKARSRMLTRLSPHALEDRGTGGTAVLSFLKSVREKTMEAILCPGA
uniprot
proteins
ec_number
1.13.11.-
uniprot
proteins
function
FUNCTION: Catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism. Involved in immune regulation. {ECO:0000250|UniProtKB:Q8R0V5}.
uniprot
proteins
mass_dalton
45236
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2.
uniprot
proteins
protein_family
3-dioxygenase family
uniprot
proteins
protein_family
Indoleamine 2
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
405
uniprot
proteins