Pspc1
entrez
66645
canonical
uniprot
Q8R326
canonical
ensembl
ENSMUSG00000021938
resolver
ensp
ENSMUSP00000022507
resolver
genesymbol
Pspc1
resolver
genesymbol_syn
Psp1
resolver
uniprot
Q3TUK2
resolver
uniprot
Q9CYH1
resolver
uniprot
Q9D0M8
resolver
uniprot_entry
PSPC1_MOUSE
resolver
uniprot_sec
Q3TUK2
resolver
uniprot_sec
Q9CYH1
resolver
uniprot_sec
Q9D0M8
resolver
amino_acid_sequence
MMLRGNLKQVRIEKNPARLRALESAAGESEPVAAAAMALTLAGEQAPPPAPSEEHPDEELGFTIDIKSFLKPGEKTYTQRCRLFVGNLPTDITEEDFKRLFERYGEPSEVFINRDRGFGFIRLESRTLAEIAKAELDGTILKSRPLRIRFATHGAALTVKNLSPVVSNELLEQAFSQFGPVEKAVVVVDDRGRATGKGFVEFAAKPPARKALERCGDGAFLLTTTPRPVIVEPMEQFDDEDGLPEKLMQKTQQYHKEREQPPRFAQPGTFEFEYASRWKALDEMEKQQREQVDRNIREAKEKLEAEMEAARHEHQLMLMRQDLMRRQEELRRLEELRNQELQKRKQIQLRHEEEHRRREEEMIRHREQEELRRQQEGGFKPNYMENREQEMRMGDMGPRGAINMGDAFSPAPAGTQGPPPMMGMNMNNRGTIPGPPMGPGPAMGPEGAANMGTPMIPDNGAVHNDRFPQGPPSQMGSPMGNRTGSETPQAPMSGVGPVSGGPGGFGRGSQGGNFEGPNKRRRY
uniprot
proteins
function
FUNCTION: RNA-binding protein required for the formation of nuclear paraspeckles. Binds to poly(A), poly(G) and poly(U) RNA homopolymers (By similarity). Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (PubMed:16641145). Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer (PubMed:22966205). Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (By similarity). {ECO:0000250|UniProtKB:Q8WXF1, ECO:0000269|PubMed:16641145, ECO:0000269|PubMed:22966205}.
uniprot
proteins
mass_dalton
58758
uniprot
proteins
mutagenesis
MUTAGEN 118; /note="F->A: Abolishes RNA-binding activity but not AR-mediated transcription coactivation; when associated with A-120; A-197 and A-199."; /evidence="ECO:0000269|PubMed:16641145"; MUTAGEN 120; /note="F->A: Abolishes RNA-binding activity but not AR-mediated transcription coactivation; when associated with A-118; A-197 and A-199."; /evidence="ECO:0000269|PubMed:16641145"; MUTAGEN 197; /note="K->A: Abolishes RNA-binding activity but not AR-mediated transcription coactivation; when associated with A-118; A-120 and A-199."; /evidence="ECO:0000269|PubMed:16641145"; MUTAGEN 199; /note="F->A: Abolishes RNA-binding activity but not AR-mediated transcription coactivation; when associated with A-118; A-120 and A-197."; /evidence="ECO:0000269|PubMed:16641145
uniprot
proteins
protein_family
PSPC family
uniprot
proteins
pubmed
15140795
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16239143
uniprot
proteins
pubmed
16641145
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22966205
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
523
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q8WXF1}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q8WXF1}. Nucleus matrix {ECO:0000269|PubMed:15140795, ECO:0000269|PubMed:16641145}. Cytoplasm {ECO:0000269|PubMed:15140795}. Note=In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. Colocalizes with NONO and SFPQ in paraspeckles and perinucleolar caps in an RNA-dependent manner. May cycle between paraspeckles and nucleolus. In telophase, when daughter nuclei form, localizes to perinucleolar caps. {ECO:0000250|UniProtKB:Q8WXF1}.
uniprot
proteins