ABHD17A
entrez
81926
canonical
uniprot
Q96GS6
canonical
ensembl
ENSG00000129968
resolver
ensp
ENSP00000250974
resolver
ensp
ENSP00000292577
resolver
ensp
ENSP00000557390
resolver
ensp
ENSP00000711111
resolver
genesymbol
ABHD17A
resolver
genesymbol_syn
C19orf27
resolver
genesymbol_syn
FAM108A1
resolver
hgnc
HGNC:28756
resolver
uniprot
A8K0G8
resolver
uniprot
D6W5Z9
resolver
uniprot
Q6PJU2
resolver
uniprot
Q8WUH9
resolver
uniprot
Q9BWL0
resolver
uniprot
Q9H7Q9
resolver
uniprot_entry
AB17A_HUMAN
resolver
uniprot_sec
A8K0G8
resolver
uniprot_sec
D6W5Z9
resolver
uniprot_sec
Q6PJU2
resolver
uniprot_sec
Q8WUH9
resolver
uniprot_sec
Q9BWL0
resolver
uniprot_sec
Q9H7Q9
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by palmostatin-B. {ECO:0000269|PubMed:26701913}.
uniprot
proteins
amino_acid_sequence
MNGLSLSELCCLFCCPPCPGRIAAKLAFLPPEATYSLVPEPEPGPGGAGAAPLGTLRASSGAPGRWKLHLTERADFQYSQRELDTIEVFPTKSARGNRVSCMYVRCVPGARYTVLFSHGNAVDLGQMSSFYIGLGSRLHCNIFSYDYSGYGASSGRPSERNLYADIDAAWQALRTRYGISPDSIILYGQSIGTVPTVDLASRYECAAVVLHSPLTSGMRVAFPDTKKTYCFDAFPNIEKVSKITSPVLIIHGTEDEVIDFSHGLALYERCPKAVEPLWVEGAGHNDIELYSQYLERLRRFISQELPSQRA
uniprot
proteins
ec_number
3.1.2.22
uniprot
proteins
function
FUNCTION: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed:26701913). Has depalmitoylating activity towards NRAS (PubMed:26701913). Has depalmitoylating activity towards DLG4/PSD95 (PubMed:26701913). May have depalmitoylating activity towards MAP6 (By similarity). {ECO:0000250|UniProtKB:Q5XIJ5, ECO:0000269|PubMed:26701913}.
uniprot
proteins
mass_dalton
33990
uniprot
proteins
mutagenesis
MUTAGEN 1..19; /note="Missing: Reduces catalytic activity. Loss of membrane localization. No effect on NRAS plasma membrane localization."; /evidence="ECO:0000269|PubMed:26701913"; MUTAGEN 190; /note="S->A: Loss of catalytic activity. No effect on its localization. No effect on NRAS plasma membrane localization."; /evidence="ECO:0000269|PubMed:26701913
uniprot
proteins
post_translational_modification
PTM: Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization (PubMed:26701913). Palmitoylation is required for post-synaptic localization and for depalmitoylating activity towards DLG4/PSD95 (By similarity). {ECO:0000250|UniProtKB:Q7M759, ECO:0000305|PubMed:26701913}.
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
protein_family
ABHD17 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
26701913
uniprot
proteins
sequence_length
310
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26701913}; Lipid-anchor {ECO:0000269|PubMed:26701913}; Cytoplasmic side {ECO:0000269|PubMed:26701913}. Endosome membrane {ECO:0000269|PubMed:26701913}; Lipid-anchor {ECO:0000269|PubMed:26701913}; Cytoplasmic side {ECO:0000269|PubMed:26701913}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q5XIJ5}. Postsynaptic density membrane {ECO:0000250|UniProtKB:Q5XIJ5}.
uniprot
proteins