SUV39H2
entrez
79723
canonical
uniprot
Q9H5I1
canonical
ensembl
ENSG00000152455
resolver
ensp
ENSP00000319208
resolver
ensp
ENSP00000346997
resolver
ensp
ENSP00000367576
resolver
ensp
ENSP00000388968
resolver
genesymbol
SUV39H2
resolver
genesymbol_syn
KMT1B
resolver
hgnc
HGNC:17287
resolver
uniprot
D3DRT4
resolver
uniprot
Q5JSS4
resolver
uniprot
Q5JSS5
resolver
uniprot
Q6I9Y3
resolver
uniprot
Q8ND06
resolver
uniprot_entry
SUV92_HUMAN
resolver
uniprot_sec
D3DRT4
resolver
uniprot_sec
Q5JSS4
resolver
uniprot_sec
Q5JSS5
resolver
uniprot_sec
Q6I9Y3
resolver
uniprot_sec
Q8ND06
resolver
amino_acid_sequence
MAAVGAEARGAWCVPCLVSLDTLQELCRKEKLTCKSIGITKRNLNNYEVEYLCDYKVVKDMEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLSQVKKGKAITPKDNNKTLKPAIAEYIVKKAKQRIALQRWQDELNRRKNHKGMIFVENTVDLEGPPSDFYYINEYKPAPGISLVNEATFGCSCTDCFFQKCCPAEAGVLLAYNKNQQIKIPPGTPIYECNSRCQCGPDCPNRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNKGITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTRTINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYLN
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Histone methyltransferase that specifically mediates trimethylation of 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' (H3K9me1) as substrate (PubMed:10949293). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones (PubMed:10949293). Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions (PubMed:10949293). H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats (PubMed:10949293, PubMed:41094145). SUV39H2 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length (PubMed:14765126). May participate in regulation of higher-order chromatin organization during spermatogenesis (By similarity). Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation (By similarity). {ECO:0000250|UniProtKB:Q9EQQ0, ECO:0000269|PubMed:10949293, ECO:0000269|PubMed:14765126, ECO:0000269|PubMed:41094145}.
uniprot
proteins
mass_dalton
46682
uniprot
proteins
mutagenesis
MUTAGEN 54; /note="D->A: Abolished ability to recognize and bind histone H3 monoubiquitinated at K-15 (H3K14ub). Does not affect binding to histone H3 trimethylated at K-9 (H3k9me3)."; /evidence="ECO:0000269|PubMed:41094145"; MUTAGEN 68; /note="W->A: Slightly decreased ability to recognize and bind histone H3 monoubiquitinated at K-15 (H3K14ub). Decreased binding to histone H3 trimethylated at K-9 (H3k9me3)."; /evidence="ECO:0000269|PubMed:41094145"; MUTAGEN 78; /note="W->A: Abolished ability to recognize and bind histone H3 monoubiquitinated at K-15 (H3K14ub). Decreased binding to histone H3 trimethylated at K-9 (H3k9me3)."; /evidence="ECO:0000269|PubMed:41094145
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the DCX(DCAF13) E3 ubiquitin ligase complex, leading to its degradation. {ECO:0000269|PubMed:30111536}.
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
Histone-lysine methyltransferase family
uniprot
proteins
protein_family
Suvar3-9 subfamily
uniprot
proteins
pubmed
10949293
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14765126
uniprot
proteins
pubmed
15107829
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20084102
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
30111536
uniprot
proteins
pubmed
41094145
uniprot
proteins
sequence_length
410
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:30111536}. Chromosome {ECO:0000269|PubMed:41094145}. Chromosome, centromere {ECO:0000250|UniProtKB:Q9EQQ0}. Note=Associates with centromeric constitutive heterochromatin (By similarity). Recruited to pericentromeric heterochromatin via its chromo domain, which specifically recognizes and binds histone H3 monoubiquitinated at 'Lys-14' (H3K14ub) (PubMed:41094145). {ECO:0000250|UniProtKB:Q9EQQ0, ECO:0000269|PubMed:41094145}.
uniprot
proteins