Mtmr2
entrez
77116
canonical
uniprot
Q9Z2D1
canonical
ensembl
ENSMUSG00000031918
resolver
ensp
ENSMUSP00000034396
resolver
ensp
ENSMUSP00000115906
resolver
ensp
ENSMUSP00000183690
resolver
ensp
ENSMUSP00000183697
resolver
enst
ENSMUST00000034396
resolver
enst
ENSMUST00000155679
resolver
genesymbol
Mtmr2
resolver
uniprot
B8JJF4
resolver
uniprot
F6UJ78
resolver
uniprot
Q6P572
resolver
uniprot
Q8VHA7
resolver
uniprot_entry
F6UJ78_MOUSE
resolver
uniprot_entry
MTMR2_MOUSE
resolver
uniprot_entry
Q6P572_MOUSE
resolver
uniprot_sec
B8JJF4
resolver
uniprot_sec
Q8VHA7
resolver
amino_acid_sequence
MEKSSSCESLGAQLPAARLPSEDSLSSASTSHSENSVHTKSASAISSDSISTSADNFSPDLRVLREANKLAEMEEPALLPGENIKDMAKDVTYICPFTGAVRGTLTVTSYRLYFKSMERDPPFVLDASLGVISRVEKIGGASSRGENSYGLETVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNGLPLFAFEYKEVFPENGWKLYDPLLEYRRQGIPNESWRITKINERYELCDTYPALLVVPANIPDEELKRVASFRSRGRIPVLSWIHPESQATVTRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPTIEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPKKTVSLWSYINSQLEDFTNPLYGSYSNHVLYPVASMRHLELWVGYYIRWNPRMKPQEPIHSRYKELLAKRAELQRKVEELQREISNRSTSSSERASSPAQCVTPVQTVV
uniprot
proteins
ec_number
3.1.3.95
uniprot
proteins
function
FUNCTION: Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:12045210, PubMed:16399794). Regulates the level of these phosphoinositides critical for various biological processes including autophagy initiation and autophagosome maturation (By similarity). {ECO:0000250|UniProtKB:Q13614, ECO:0000269|PubMed:12045210, ECO:0000269|PubMed:16399794}.
uniprot
proteins
mass_dalton
73232
uniprot
proteins
mutagenesis
MUTAGEN 103; /note="G->E: Severely impaired interaction with membranes and strongly reduced catalytic activity."; /evidence="ECO:0000269|PubMed:12045210, ECO:0000269|PubMed:14530412"; MUTAGEN 417; /note="C->A: Loss of activity. Does not affect the interaction with SBF2/MTMR13."; /evidence="ECO:0000269|PubMed:14530412, ECO:0000269|PubMed:16399794"; MUTAGEN 589..643; /note="Missing: Loss of interaction with SBF2/MTMR13 which results in a decrease in SBF2/MTMR13 localization to membranes."; /evidence="ECO:0000269|PubMed:16399794, ECO:0000269|PubMed:23297362
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-58 decreases MTMR2 localization to endocytic vesicular structures. {ECO:0000250|UniProtKB:Q13614}.
uniprot
proteins
protein_family
Non-receptor class myotubularin subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
12045210
uniprot
proteins
pubmed
14530412
uniprot
proteins
pubmed
16399794
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23297362
uniprot
proteins
pubmed
34718573
uniprot
proteins
pubmed
9736772
uniprot
proteins
sequence_length
643
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14530412, ECO:0000269|PubMed:16399794, ECO:0000269|PubMed:23297362}. Early endosome membrane {ECO:0000250|UniProtKB:Q13614}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q13614}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:14530412}. Cell projection, axon {ECO:0000269|PubMed:23297362}. Endosome membrane {ECO:0000269|PubMed:23297362}; Peripheral membrane protein {ECO:0000305}. Note=Partly associated with membranes (PubMed:14530412, PubMed:23297362). Localizes to vacuoles in hypo-osmotic conditions (PubMed:16399794). {ECO:0000269|PubMed:14530412, ECO:0000269|PubMed:16399794, ECO:0000269|PubMed:23297362}.
uniprot
proteins