Q715S9
uniprot
Q715S9
canonical
amino_acid_sequence
MASKKREVQLQSVVNSQNLWDEMLLNKGLTVIDVYQAWCGPCKAVQALFRKLKNELNEDELLHFVVAEADSIVTLQPFRDKCEPVFLFSLNGKIIAKIQGANAPLINRKVIALIDEEKKIAAGEMARPQYVEIPLVDSLDEEYGEVHYESNVEVYNMAVINPDAVLMRKNLEIKEKITKEGFIIEIQENMLLPEEVAREFYNHMIDEPDFEEFVYSMTNRLSCVLIISQGEDTEVIEEEALPQSDDEEEPDPLEEPHVRFAPMLVKKKRDSLQEYMDRQHMSDYCHVEDDAVKVSKFIDILFPDFKTMKSTNVQRTLGLLYPEVCEEEKDNVLDIIQNEGFTILMQRQVVLSEEEARAVCHVHEDEDYFDNLIGYMCSNNSYILVLMREHSVERWKELIGPKTVEEAYASHPDSLCVRFASGNFPVNQFYGSSSKAAAETEIEHFFPPQSTLALIKPHVSHKERMEILKAIRDARFELTQMKEMHLTPEHASKVYFKITGKDFYKNVLDVLSSGMSVVMILTKWNAVGEWRRMMGPVDPEEAKLLSPNSLRARYGIDVLRNAVHGASNMSEAATAISNVFTESNFEN
uniprot
proteins
ec_number
2.7.-.-
uniprot
proteins
ec_number
3.1.11.-
uniprot
proteins
function
FUNCTION: Possesses an intrinsic kinase activity. In vitro, does not exhibit nucleoside diphosphate kinase (NDPK) activity or disulfide bond-reducing activity. Additionally, exhibits a 3'-5'-DNA exonuclease activity that removes single nucleotides from the 3' terminus of single-stranded DNA substrates and digests overhanging mismatched 3' termini from double-stranded DNA substrates, suggesting a role in DNA nucleolytic processing (By similarity). May be required during the final stages of sperm tail maturation in the testis and/or epididymis, where extensive disulfide bonding of fibrous sheath (FS) proteins occurs (Probable). {ECO:0000250|UniProtKB:Q8N427, ECO:0000305|PubMed:12909633}.
uniprot
proteins
mass_dalton
67312
uniprot
proteins
post_translational_modification
PTM: Undergoes autophosphorylation. {ECO:0000250|UniProtKB:Q8N427}.
uniprot
proteins
protein_family
NDK family
uniprot
proteins
pubmed
12909633
uniprot
proteins
sequence_length
587
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12909633}. Note=In spermatozoa, it is an integral component of the fibrous sheath (FS). {ECO:0000269|PubMed:12909633}.
uniprot
proteins