Stx17
entrez
67727
canonical
uniprot
Q9D0I4
canonical
ensembl
ENSMUSG00000061455
resolver
ensp
ENSMUSP00000068087
resolver
ensp
ENSMUSP00000103348
resolver
enst
ENSMUST00000064765
resolver
enst
ENSMUST00000107720
resolver
genesymbol
Stx17
resolver
uniprot
B1AVI3
resolver
uniprot
Q9D330
resolver
uniprot_entry
STX17_MOUSE
resolver
uniprot_sec
B1AVI3
resolver
uniprot_sec
Q9D330
resolver
amino_acid_sequence
MSEDEEKVKLRRLEPAIQKFTKIVIPTDLERLRKHQINIEKYQRCRIWDKLHEEHINAGRTVQQLRSNIREMEKLCLKVHKDDLVLLKRMIDPVKEAAATATAEFLQLHLESVEELKKQVNDEELLQPSLTRSTTVDGVLHTGEAEAASQSLTQIYALPEIPQDQNAAESWETLEADLIELSHLVTDMSLLVSSQQEKIDSIADHVNSAAVNVEEGTKNLQKAAKYKLAALPVAGALIGGVVGGPIGLLAGFKVAGIAAALGGGVLGFTGGKLIQRRKQKMMEKLTSSCPDLPSQSDKKRS
uniprot
proteins
function
FUNCTION: SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (By similarity). {ECO:0000250|UniProtKB:P56962}.
uniprot
proteins
mass_dalton
33221
uniprot
proteins
post_translational_modification
PTM: Dephosphorylation by PTPN2; regulates exit from the endoplasmic reticulum (By similarity). Phosphorylated at Tyr-156 probably by ABL1 (PubMed:23006999). {ECO:0000250|UniProtKB:Q9Z158, ECO:0000269|PubMed:23006999}.
uniprot
proteins
protein_family
Syntaxin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23006999
uniprot
proteins
pubmed
23217709
uniprot
proteins
pubmed
27628032
uniprot
proteins
sequence_length
301
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P56962}; Multi-pass membrane protein {ECO:0000255}. Smooth endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Z158}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:P56962}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:27628032}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000250|UniProtKB:Q9Z158}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9Z158}. Mitochondrion membrane {ECO:0000250|UniProtKB:P56962}; Multi-pass membrane protein {ECO:0000255}. Autolysosome membrane {ECO:0000250|UniProtKB:P56962}; Multi-pass membrane protein {ECO:0000255}. Note=Has a hairpin-like insertion into membranes. Localizes to the completed autophagosome membrane upon cell starvation (By similarity). Colocalized with RAB39A and RAB39B in autolysosomes in autophagy-induced conditions (By similarity). {ECO:0000250|UniProtKB:P56962}.
uniprot
proteins
transmembrane_region
TRANSMEM 228..248; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 254..274; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins