Ttpa
entrez
50500
canonical
uniprot
Q8BWP5
canonical
ensembl
ENSMUSG00000073988
resolver
ensp
ENSMUSP00000113026
resolver
ensp
ENSMUSP00000113966
resolver
enst
ENSMUST00000117632
resolver
enst
ENSMUST00000121491
resolver
genesymbol
Ttpa
resolver
uniprot
A8Y5N9
resolver
uniprot
Q499J3
resolver
uniprot
Q9CW51
resolver
uniprot
Q9JL07
resolver
uniprot_entry
A8Y5N9_MOUSE
resolver
uniprot_entry
Q499J3_MOUSE
resolver
uniprot_entry
TTPA_MOUSE
resolver
uniprot_sec
Q9CW51
resolver
uniprot_sec
Q9JL07
resolver
amino_acid_sequence
MAEMRPGPLVGKQLNELPDHSPLLQPGLAELRRRVQEAGVPQTPQPLTDAFLLRFLRARDFDLDLAWRLMKNYYKWRAECPELSADLRPRSILGLLKAGYHGVLRSRDSTGSRVLIYRIAYWDPKVFTAYDVFRVSLITSELIVQEVETQRNGVKAIFDLEGWQVSHAFQITPSVAKKIAAVLTDSFPLKVRGIHLINEPVIFHAVFSMIKPFLTEKIKDRIHLHGNNYKSSMLQHFPDILPREYGGKEFSMEDICQEWTNFIMKSEDYLSSISETIQ
uniprot
proteins
function
FUNCTION: Binds (+)-alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells. Binds both phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol. {ECO:0000269|PubMed:23599266}.
uniprot
proteins
mass_dalton
32014
uniprot
proteins
mutagenesis
MUTAGEN 59; /note="R->W: Abolishes binding to phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 4,5-bisphosphate."; /evidence="ECO:0000269|PubMed:23599266"; MUTAGEN 217; /note="K->A: Loss of tocopherol secretion (in vivo). No effect on tocopherol binding and intermembrane transfer (in vitro)."; /evidence="ECO:0000269|PubMed:23599266"; MUTAGEN 221; /note="R->W: Loss of tocopherol secretion (in vivo). No effect on tocopherol binding and intermembrane transfer (in vitro)."; /evidence="ECO:0000269|PubMed:23599266
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23599266
uniprot
proteins
sequence_length
278
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins