PIGZ
entrez
80235
canonical
uniprot
Q86VD9
canonical
ensembl
ENSG00000119227
resolver
ensp
ENSP00000413405
resolver
ensp
ENSP00000580307
resolver
ensp
ENSP00000580308
resolver
ensp
ENSP00000580309
resolver
ensp
ENSP00000628139
resolver
ensp
ENSP00000628140
resolver
ensp
ENSP00000628141
resolver
enst
ENST00000412723
resolver
enst
ENST00000910248
resolver
enst
ENST00000910249
resolver
enst
ENST00000910250
resolver
enst
ENST00000958080
resolver
enst
ENST00000958081
resolver
enst
ENST00000958082
resolver
genesymbol
PIGZ
resolver
genesymbol_syn
SMP3
resolver
hgnc
HGNC:30596
resolver
uniprot
B4DL68
resolver
uniprot
Q9H9G6
resolver
uniprot_entry
B4DL68_HUMAN
resolver
uniprot_entry
PIGZ_HUMAN
resolver
uniprot_sec
Q9H9G6
resolver
amino_acid_sequence
MQICGSSVASVAAGTSFQVLGPVCWQQLDLKMAVRVLWGGLSLLRVLWCLLPQTGYVHPDEFFQSPEVMAEDILGVQAARPWEFYPSSSCRSVLFPLLISGSTFWLLRLWEELGPWPGLVSGYALLVGPRLLLTALSFALDGAVYHLAPPMGADRWNALALLSGSYVTLVFYTRTFSNTIEGLLFTWLLVLVSSHVTWGPTRKEPAPGPRWRSWLLGGIVAAGFFNRPTFLAFAVVPLYLWGTRGATNPGLKSLTREALVLLPGAALTAAVFVATDSWYFSSPATSRNLVLTPVNFLHYNLNPQNLARHGTHARLTHLAVNGFLLFGVLHAQALQAAWQRLQVGLQASAQMGLLRALGARSLLSSPRSYLLLLYFMPLALLSAFSHQEARFLIPLLVPLVLLCSPQTQPVPWKGTVVLFNALGALLFGCLHQGGLVPGLEYLEQVVHAPVLPSTPTHYTLLFTHTYMPPRHLLHLPGLGAPVEVVDMGGTEDWALCQTLKSFTRQPACQVAGGPWLCRLFVVTPGTTRRAVEKCSFPFKNETLLFPHLTLEDPPALSSLLSGAWRDHLSLHIVELGEET
uniprot
proteins
ec_number
2.4.1.-
uniprot
proteins
function
FUNCTION: Alpha-1,2-mannosyltransferase that catalyzes the transfer of the fourth mannose, via an alpha-1,2 bond, from a dolichol-phosphate-mannose (Dol-P-Man) to a 2-acyl-6-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed H6) intermediate to generate a 2-acyl-6-[alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->2)-alpha-D-mannosyl-(1->6)-2-phosphoethanolamine-alpha-D-mannosyl-(1->4)-alpha-D-glucosaminyl]-1-(1-radyl,2-acyl-sn-glycero-3-phospho)-1D-myo-inositol (also termed M4C) and participates in the twelfth step of the glycosylphosphatidylinositol-anchor biosynthesis (Probable). The presence of a fourth mannose in GPI is facultative, suggesting that it only exists in some tissues (Probable). {ECO:0000305|PubMed:15208306}.
uniprot
proteins
mass_dalton
63471
uniprot
proteins
pathway_participation
PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. {ECO:0000269|PubMed:15208306}.
uniprot
proteins
protein_family
Glycosyltransferase 22 family
uniprot
proteins
protein_family
PIGZ subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15208306
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
sequence_length
579
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15208306}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 131..151; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 156..173; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 180..200; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 216..236; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 258..278; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 369..389; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 391..411; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 416..436; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins