COMMD8
entrez
54951
canonical
uniprot
Q9NX08
canonical
ensembl
ENSG00000169019
resolver
ensp
ENSP00000370984
resolver
ensp
ENSP00000530393
resolver
enst
ENST00000381571
resolver
genesymbol
COMMD8
resolver
hgnc
HGNC:26036
resolver
uniprot
Q8WUR4
resolver
uniprot
Q9HC15
resolver
uniprot_entry
COMD8_HUMAN
resolver
uniprot_sec
Q8WUR4
resolver
uniprot_sec
Q9HC15
resolver
amino_acid_sequence
MEPEEGTPLWRLQKLPAELGPQLLHKIIDGICGRAYPVYQDYHTVWESEEWMHVLEDIAKFFKAIVGKNLPDEEIFQQLNQLNSLHQETIMKCVKSRKDEIKQALSREIVAISSAQLQDFDWQVKLALSSDKIAALRMPLLSLHLDVKENGEVKPYSIEMSREELQNLIQSLEAANKVVLQLK
uniprot
proteins
function
FUNCTION: Scaffold protein in the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:38459129). May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). May down-regulate activation of NF-kappa-B (PubMed:15799966). {ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:37172566, ECO:0000269|PubMed:38459129, ECO:0000305|PubMed:21778237}.
uniprot
proteins
mass_dalton
21090
uniprot
proteins
protein_family
COMM domain-containing protein 8 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15799966
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21778237
uniprot
proteins
pubmed
23563313
uniprot
proteins
pubmed
23637203
uniprot
proteins
pubmed
25355947
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28892079
uniprot
proteins
pubmed
37172566
uniprot
proteins
pubmed
38459129
uniprot
proteins
pubmed
38504028
uniprot
proteins
sequence_length
183
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21778237}. Nucleus {ECO:0000269|PubMed:21778237}.
uniprot
proteins