SLC48A1
entrez
55652
canonical
uniprot
Q6P1K1
canonical
ensembl
ENSG00000211584
resolver
ensp
ENSP00000415998
resolver
genesymbol
SLC48A1
resolver
genesymbol_syn
HRG1
resolver
hgnc
HGNC:26035
resolver
uniprot
Q9BUB3
resolver
uniprot
Q9NX17
resolver
uniprot_entry
HRG1_HUMAN
resolver
uniprot_sec
Q9BUB3
resolver
uniprot_sec
Q9NX17
resolver
amino_acid_sequence
MAPSRLQLGLRAAYSGISSVAGFSIFLVWTVVYRQPGTAAMGGLAGVLALWVLVTHVMYMQDYWRTWLKGLRGFFFVGVLFSAVSIAAFCTFLVLAITRHQSLTDPTSYYLSSVWSFISFKWAFLLSLYAHRYRADFADISILSDF
uniprot
proteins
function
FUNCTION: Heme transporter that regulates intracellular heme availability through the endosomal or lysosomal compartment (PubMed:18418376). In macrophages of the reticuloendothelial system, is the heme transporter for heme-iron recycling. Essential for macrophage iron homeostasis, transports heme from the phagolysosome to the cytoplasm during erythrophagocytosis (EP) (PubMed:23395172). {ECO:0000269|PubMed:18418376, ECO:0000269|PubMed:23395172}.
uniprot
proteins
mass_dalton
16419
uniprot
proteins
mutagenesis
MUTAGEN 36; /note="P->L: Strongly decreases heme transport."; /evidence="ECO:0000269|PubMed:23395172"; MUTAGEN 73; /note="G->S: No effect on heme transport."; /evidence="ECO:0000269|PubMed:23395172"; MUTAGEN 82; /note="S->L: No effect on heme transport."; /evidence="ECO:0000269|PubMed:23395172"; MUTAGEN 115; /note="W->C: Slightly decreases heme transport."; /evidence="ECO:0000269|PubMed:23395172
uniprot
proteins
protein_family
HRG family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18418376
uniprot
proteins
pubmed
23395172
uniprot
proteins
sequence_length
146
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:18418376, ECO:0000269|PubMed:23395172}; Multi-pass membrane protein {ECO:0000269|PubMed:18418376}. Lysosome membrane {ECO:0000269|PubMed:18418376, ECO:0000269|PubMed:23395172}; Multi-pass membrane protein {ECO:0000269|PubMed:18418376}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9D8M3}; Multi-pass membrane protein {ECO:0000255}. Note=In macrophages, specifically localizes to the phagolysosomal membranes during erythrophagocytosis. {ECO:0000250|UniProtKB:Q9D8M3}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 40..60; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 74..94; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 110..130; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins