Pkmyt1
entrez
268930
canonical
uniprot
Q9ESG9
canonical
ensembl
ENSMUSG00000023908
resolver
ensp
ENSMUSP00000024701
resolver
ensp
ENSMUSP00000250930
resolver
ensp
ENSMUSP00000250931
resolver
ensp
ENSMUSP00000342723
resolver
enst
ENSMUST00000024701
resolver
genesymbol
Pkmyt1
resolver
genesymbol_syn
Myt1
resolver
uniprot
Q3TNN2
resolver
uniprot
Q8R3L4
resolver
uniprot_entry
PMYT1_MOUSE
resolver
uniprot_sec
Q3TNN2
resolver
uniprot_sec
Q8R3L4
resolver
activity_regulation
ACTIVITY REGULATION: Negatively regulated by hyperphosphorylation during mitosis. The hyperphosphorylated form does not associate with CCNB1-CDC2 complexes. The PLK1 protein kinase may be required for mitotic phosphorylation. {ECO:0000250|UniProtKB:Q99640}.
uniprot
proteins
amino_acid_sequence
MTMPTEGTPPPLSGTPIPVPAYFRHAEPGFSLKRPGGLSRSLPPRPPAKGCIPVSRLFPPRTPGWHQPQPRRVSFLCETSEPLQSPGYDPSRPESFFQQNFQRLSRLGHGSYGEVFKVRSKEDGRLYAVKRYMSPFRGPKDRTRKLAEVGGHEKVGQHPHCVRLERAWEEGGILYLQTELCGPSLQQHCEAWGASLPEAQVWGYLRDILLALDHLHSQGLVHLDVKPANIFLGPRGRCKLGDFGLLVELGSAGAGEAQEGDPRYMAPELLQGSYGTAADVFSLGLTILEVACNMELPHGGEGWQQLRQGYLPPEFTAGLSSELRSVLAMMLEPDPQLRATAEALLALPMLRQPRPWNVLWYMAAEALSRGWALWQALVTLLCWLWHGLVHPASWLQPPGPPATPPGSPPCSPLLDSTLSSSWDNDSIGPSLSPETVLSRITRRTSTPRGRYIPRDALDLTDVDSEPPRGPCPTFEPRNLLSLFEDSLDPA
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. {ECO:0000250|UniProtKB:Q99640}.
uniprot
proteins
mass_dalton
54053
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. Phosphorylated by CDC2-CCNB1 complexes on undefined serine and threonine residues. The phosphorylation by CDC2-CCNB1 complexes may inhibit the catalytic activity. {ECO:0000250|UniProtKB:Q99640}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Ser/Thr protein kinase family
uniprot
proteins
protein_family
WEE1 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
490
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q99640}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q99640}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q99640}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q99640}.
uniprot
proteins