EIF3E
entrez
3646
canonical
uniprot
P60228
canonical
ensembl
ENSG00000104408
resolver
ensp
ENSP00000220849
resolver
enst
ENST00000220849
resolver
genesymbol
EIF3E
resolver
genesymbol_syn
EIF3S6
resolver
genesymbol_syn
INT6
resolver
hgnc
HGNC:3277
resolver
uniprot
O43902
resolver
uniprot
Q64058
resolver
uniprot
Q64059
resolver
uniprot
Q64252
resolver
uniprot
Q6FG33
resolver
uniprot
Q8WVK4
resolver
uniprot_entry
EIF3E_HUMAN
resolver
uniprot_sec
O43902
resolver
uniprot_sec
Q64058
resolver
uniprot_sec
Q64059
resolver
uniprot_sec
Q64252
resolver
uniprot_sec
Q6FG33
resolver
uniprot_sec
Q8WVK4
resolver
amino_acid_sequence
MAEYDLTTRIAHFLDRHLVFPLLEFLSVKEIYNEKELLQGKLDLLSDTNMVDFAMDVYKNLYSDDIPHALREKRTTVVAQLKQLQAETEPIVKMFEDPETTRQMQSTRDGRMLFDYLADKHGFRQEYLDTLYRYAKFQYECGNYSGAAEYLYFFRVLVPATDRNALSSLWGKLASEILMQNWDAAMEDLTRLKETIDNNSVSSPLQSLQQRTWLIHWSLFVFFNHPKGRDNIIDLFLYQPQYLNAIQTMCPHILRYLTTAVITNKDVRKRRQVLKDLVKVIQQESYTYKDPITEFVECLYVNFDFDGAQKKLRECESVLVNDFFLVACLEDFIENARLFIFETFCRIHQCISINMLADKLNMTPEEAERWIVNLIRNARLDAKIDSKLGHVVMGNNAVSPYQQVIEKTKSLSFRSQMLAMNIEKKLNQNSRSEAPNWATQDSGFY
uniprot
proteins
function
FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway (PubMed:17468741). May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins (PubMed:17310990, PubMed:17324924). {ECO:0000255|HAMAP-Rule:MF_03004, ECO:0000269|PubMed:17310990, ECO:0000269|PubMed:17324924, ECO:0000269|PubMed:17468741, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.
uniprot
proteins
mass_dalton
52221
uniprot
proteins
mutagenesis
MUTAGEN 312; /note="L->D: Promotes nuclear accumulation."; /evidence="ECO:0000269|PubMed:17761670
uniprot
proteins
protein_family
EIF-3 subunit E family
uniprot
proteins
pubmed
10504338
uniprot
proteins
pubmed
11457827
uniprot
proteins
pubmed
11590142
uniprot
proteins
pubmed
12220626
uniprot
proteins
pubmed
12386384
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15703437
uniprot
proteins
pubmed
16023166
uniprot
proteins
pubmed
16322461
uniprot
proteins
pubmed
16766523
uniprot
proteins
pubmed
16973618
uniprot
proteins
pubmed
17310990
uniprot
proteins
pubmed
17322308
uniprot
proteins
pubmed
17324924
uniprot
proteins
pubmed
17468741
uniprot
proteins
pubmed
17581632
uniprot
proteins
pubmed
17761670
uniprot
proteins
pubmed
18599441
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21745818
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25849773
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27462815
uniprot
proteins
pubmed
8688078
uniprot
proteins
pubmed
9295280
uniprot
proteins
pubmed
9403073
uniprot
proteins
sequence_length
445
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus, PML body.
uniprot
proteins