Ifng
entrez
15978
canonical
uniprot
P01580
canonical
ensembl
ENSMUSG00000055170
resolver
ensp
ENSMUSP00000063800
resolver
enst
ENSMUST00000068592
resolver
genesymbol
Ifng
resolver
genesymbol_syn
If2f
resolver
uniprot
A0A7R8C347
resolver
uniprot
Q542B8
resolver
uniprot_entry
A0A7R8C347_MOUSE
resolver
uniprot_entry
IFNG_MOUSE
resolver
uniprot_sec
Q542B8
resolver
amino_acid_sequence
MNATHCILALQLFLMAVSGCYCHGTVIESLESLNNYFNSSGIDVEEKSLFLDIWRNWQKDGDMKILQSQIISFYLRLFEVLKDNQAISNNISVIESHLITTFFSNSKAKKDAFMSIAKFEVNNPQVQRQAFNELIRVVHQLLPESSLRKRKRSRC
uniprot
proteins
function
FUNCTION: Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial, antiviral, and antitumor responses by activating effector immune cells and enhancing antigen presentation (PubMed:11585387, PubMed:8456301). Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding, IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2, JAK1 and STAT1, leading to STAT1 activation, nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn, increases the quantity, quality, and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the expression of activator PA28 that associates with the proteasome and alters its proteolytic cleavage preference. Up-regulates as well MHC II complexes on the cell surface by promoting expression of several key molecules such as cathepsins B/CTSB, H/CTSH, and L/CTSL (By similarity). Participates in the regulation of hematopoietic stem cells during development and under homeostatic conditions by affecting their development, quiescence, and differentiation (PubMed:20535209, PubMed:25078851). {ECO:0000250|UniProtKB:P01579, ECO:0000269|PubMed:11585387, ECO:0000269|PubMed:20535209, ECO:0000269|PubMed:25078851, ECO:0000269|PubMed:8456301}.
uniprot
proteins
mass_dalton
17907
uniprot
proteins
protein_family
Type II (or gamma) interferon family
uniprot
proteins
pubmed
11585387
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20535209
uniprot
proteins
pubmed
25078851
uniprot
proteins
pubmed
6310596
uniprot
proteins
pubmed
8456301
uniprot
proteins
sequence_length
155
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01579}.
uniprot
proteins