MPST
entrez
4357
canonical
uniprot
P25325
canonical
ensembl
ENSG00000128309
resolver
ensp
ENSP00000342333
resolver
ensp
ENSP00000383950
resolver
ensp
ENSP00000384812
resolver
ensp
ENSP00000411719
resolver
ensp
ENSP00000788098
resolver
genesymbol
MPST
resolver
genesymbol_syn
TST2
resolver
hgnc
HGNC:7223
resolver
uniprot
A0A140VJX3
resolver
uniprot
A8MZ34
resolver
uniprot
B3KP52
resolver
uniprot
J3KPV7
resolver
uniprot
O75750
resolver
uniprot
Q6FHN9
resolver
uniprot_entry
A0A140VJX3_HUMAN
resolver
uniprot_entry
THTM_HUMAN
resolver
uniprot_sec
A8MZ34
resolver
uniprot_sec
B3KP52
resolver
uniprot_sec
J3KPV7
resolver
uniprot_sec
O75750
resolver
uniprot_sec
Q6FHN9
resolver
activity_regulation
ACTIVITY REGULATION: By oxidative stress, and thioredoxin. Under oxidative stress conditions, the catalytic cysteine site is converted to a sulfenate which inhibits the MPST enzyme activity. Reduced thioredoxin cleaves an intersubunit disulfide bond to turn on the redox switch and reactivate the enzyme. {ECO:0000250|UniProtKB:P97532}.
uniprot
proteins
amino_acid_sequence
MASPQLCRALVSAQWVAEALRAPRAGQPLQLLDASWYLPKLGRDARREFEERHIPGAAFFDIDQCSDRTSPYDHMLPGAEHFAEYAGRLGVGAATHVVIYDASDQGLYSAPRVWWMFRAFGHHAVSLLDGGLRHWLRQNLPLSSGKSQPAPAEFRAQLDPAFIKTYEDIKENLESRRFQVVDSRATGRFRGTEPEPRDGIEPGHIPGTVNIPFTDFLSQEGLEKSPEEIRHLFQEKKVDLSKPLVATCGSGVTACHVALGAYLCGKPDVPIYDGSWVEWYMRARPEDVISEGRGKTH
uniprot
proteins
disease_involvement
DISEASE: Note=Aberrant MPST activity is found in a few cases of mercaptolactate-cysteine disulfiduria (MCDU) characterized by the appearance of large quantaties of the sulfur-containing amino acid, beta-mercaptolactate-cysteine disulfide, in the urine (PubMed:4690911, PubMed:4973015, PubMed:6945862). Some cases have associated intellectual disability (PubMed:4973015, PubMed:6945862).
uniprot
proteins
ec_number
2.8.1.2
uniprot
proteins
function
FUNCTION: Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regulated by calcium ions. {ECO:0000250|UniProtKB:P97532}.
uniprot
proteins
mass_dalton
33178
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
1953758
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
4690911
uniprot
proteins
pubmed
4973015
uniprot
proteins
pubmed
6945862
uniprot
proteins
sequence_length
297
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P97532}. Mitochondrion {ECO:0000250|UniProtKB:P97532}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q99J99}.
uniprot
proteins