Adcy3
entrez
64508
canonical
uniprot
P21932
canonical
ensembl
ENSRNOG00000003999
resolver
ensp
ENSRNOP00000005389
resolver
enst
ENSRNOT00000005389
resolver
genesymbol
Adcy3
resolver
uniprot
G3V6I2
resolver
uniprot_entry
ADCY3_RAT
resolver
uniprot_entry
G3V6I2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Specifically activated by the G alpha protein GNAL/G(olf) in signaling cascades triggered by odorant receptors (PubMed:2255909). Specifically activated by the G alpha protein GNAS/G(s) in primary cilia (By similarity). Activated by forskolin (PubMed:1633161, PubMed:2255909, PubMed:24363043). After forskolin treatment, activity is further increased by calcium/calmodulin (PubMed:1633161). In the absence of forskolin, calcium/calmodulin has little effect on enzyme activity (PubMed:1633161). {ECO:0000250|UniProtKB:O60266, ECO:0000269|PubMed:1633161, ECO:0000269|PubMed:2255909, ECO:0000269|PubMed:24363043}.
uniprot
proteins
amino_acid_sequence
MTEDQGFSDPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPESLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLAPLMVAGVGLVLDIILFVLCKKGLLPDRVSRKVVPYLLWLLITAQIFSYLGLNFSRAHAASDTVGWQAFFVFSFFITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQDELEGMQLLREILANVFLYLCAIIVGIMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQLRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSRCDYLDEKGIETYLIIASKPEVKKTAQNGLNGSALPNGAPASKPSSPALIETKEPNGSAHASGSTSEEAEEQEAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLTMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLFCTAMVEILIDPWLMTNYVTFVVGEVLLLILTICSMAAIFPRAFPKKLVAFSSWIDRTRWARNTWAMLAIFILVMANVVDMLSCLQYYMGPYNVTTGIELDGGCMENPKYYNYVAVLSLIATIMLVQVSHMVKLTLMLLVTGAVTAINLYAWCPVFDEYDHKRFQEKDSPMVALEKMQVLSTPGLNGTDSRLPLVPSKYSMTVMMFVMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQSYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFTSSSKEEKSDKERWQHLADLADFALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDRPAAFPNGSSVTLPHQVVDNP
uniprot
proteins
ec_number
4.6.1.1
uniprot
proteins
function
FUNCTION: Catalyzes the formation of the signaling molecule cAMP in response to G protein signaling (PubMed:1633161, PubMed:2255909, PubMed:24363043). Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis: specifically activated by G alpha protein GNAL/G(olf) in olfactory epithelium (PubMed:2255909). Mediates signaling cascades in primary cilia: specifically activated by G alpha protein GNAS/G(s) in primary cilia. Plays a role in regulating food intake and body fat accumulation in the paraventricular nucleus of the hypothalamus (PVH) by acting downstream of MC4R activation (By similarity). Required for normal sperm motility and normal male fertility (By similarity). {ECO:0000250|UniProtKB:O60266, ECO:0000250|UniProtKB:Q8VHH7, ECO:0000269|PubMed:1633161, ECO:0000269|PubMed:2255909, ECO:0000269|PubMed:24363043}.
uniprot
proteins
mass_dalton
128936
uniprot
proteins
mutagenesis
MUTAGEN 465; /note="K->R: Abolishes sumoylation. Abolishes location at cilia in the olfactory epithelium."; /evidence="ECO:0000269|PubMed:25908845
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:2255909}.; PTM: Sumoylated. Sumoylation is required for targeting to olfactory cilia. {ECO:0000269|PubMed:25908845}.; PTM: Rapidly phosphorylated after stimulation by odorants or forskolin. Phosphorylation by CaMK2 at Ser-1076 down-regulates enzyme activity. {ECO:0000250|UniProtKB:Q8VHH7}.
uniprot
proteins
protein_family
Adenylyl cyclase class-4/guanylyl cyclase family
uniprot
proteins
pubmed
15705663
uniprot
proteins
pubmed
1633161
uniprot
proteins
pubmed
2255909
uniprot
proteins
pubmed
24363043
uniprot
proteins
pubmed
25908845
uniprot
proteins
sequence_length
1144
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15705663, ECO:0000269|PubMed:1633161}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium membrane {ECO:0000269|PubMed:2255909, ECO:0000269|PubMed:25908845}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O60266}. Cytoplasm {ECO:0000250|UniProtKB:O60266}. Golgi apparatus {ECO:0000269|PubMed:15705663}.
uniprot
proteins
transmembrane_region
TRANSMEM 80..100; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 105..125; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 139..159; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 173..193; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 226..246; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 381..401; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 631..651; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 662..682; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 706..726; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 755..775; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 777..797; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 833..853; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins