JUN
entrez
3725
canonical
uniprot
P05412
canonical
ensembl
ENSG00000177606
resolver
ensp
ENSP00000360266
resolver
ensp
ENSP00000503132
resolver
enst
ENST00000371222
resolver
enst
ENST00000678696
resolver
genesymbol
JUN
resolver
hgnc
HGNC:6204
resolver
uniprot
Q6FHM7
resolver
uniprot
Q96G93
resolver
uniprot_entry
JUN_HUMAN
resolver
uniprot_sec
Q6FHM7
resolver
uniprot_sec
Q96G93
resolver
amino_acid_sequence
MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDLLTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGALSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
uniprot
proteins
function
FUNCTION: Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (PubMed:10995748, PubMed:22083952). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (PubMed:12618758). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (PubMed:17210646). Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells (PubMed:24623306). Binds to the USP28 promoter in colorectal cancer (CRC) cells (PubMed:24623306). {ECO:0000250|UniProtKB:P05627, ECO:0000269|PubMed:10995748, ECO:0000269|PubMed:12618758, ECO:0000269|PubMed:17210646, ECO:0000269|PubMed:22083952, ECO:0000269|PubMed:24623306}.; FUNCTION: (Microbial infection) Upon Epstein-Barr virus (EBV) infection, binds to viral BZLF1 Z promoter and activates viral BZLF1 expression. {ECO:0000269|PubMed:31341047}.
uniprot
proteins
mass_dalton
35676
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="T->A: Complete loss of PAK2-mediated phosphorylation; when associated with A-8; A-89; A-93; and A-286."; /evidence="ECO:0000269|PubMed:21177766"; MUTAGEN 6..194; /note="Missing: Abolishes activation of FASLG/CD95L transcription."; /evidence="ECO:0000269|PubMed:12618758"; MUTAGEN 8; /note="T->A: Complete loss of PAK2-mediated phosphorylation; when associated with A-2; A-89; A-93; and A-286."; /evidence="ECO:0000269|PubMed:21177766"; MUTAGEN 63; /note="S->A: Greatly reduced ATF7-mediated transcriptional activity; when associated with A-73. Abolishes interaction with FBXW7; when associated with A-73; A-91 and A-93."; /evidence="ECO:0000269|PubMed:10376527, ECO:0000269|PubMed:14739463"; MUTAGEN 73; /note="S->A: Greatly reduced ATF7-mediated transcriptional activity; when associated with A-63. Abolishes interaction with FBXW7; when associated with A-63; A-91 and A-93."; /evidence="ECO:0000269|PubMed:10376527, ECO:0000269|PubMed:14739463"; MUTAGEN 89; /note="T->A: Complete loss of PAK2-mediated phosphorylation; when associated with A-2; A-8; A-93; and A-286."; /evidence="ECO:0000269|PubMed:21177766"; MUTAGEN 91; /note="T->A: Abolishes interaction with FBXW7; when associated with A-63; A-73 and A-93."; /evidence="ECO:0000269|PubMed:14739463"; MUTAGEN 93; /note="T->A: Abolishes interaction with FBXW7; when associated with A-63; A-73 and A-91."; /evidence="ECO:0000269|PubMed:14739463"; MUTAGEN 93; /note="T->A: Complete loss of PAK2-mediated phosphorylation; when associated with A-2; A-8; A-89; and A-286."; /evidence="ECO:0000269|PubMed:21177766"; MUTAGEN 243; /note="S->A: Abolishes phosphorylation by DYRK2. Abolishes phosphorylation by GSK3B at Thr-239."; /evidence="ECO:0000269|PubMed:22307329"; MUTAGEN 272; /note="R->V: Abolishes the synergistic activity with SMAD3 to activate TGF-beta-mediated transcription."; /evidence="ECO:0000269|PubMed:10995748"; MUTAGEN 286; /note="T->A: Complete loss of PAK2-mediated phosphorylation; when associated with A-2; A-8; A-89; and A-93."; /evidence="ECO:0000269|PubMed:21177766
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the SCF(FBXW7), leading to its degradation (PubMed:14739463, PubMed:27458189). Ubiquitination takes place following phosphorylation, that promotes interaction with FBXW7 (PubMed:14739463). {ECO:0000269|PubMed:14739463, ECO:0000269|PubMed:27458189}.; PTM: Phosphorylated by CaMK4 and PRKDC; phosphorylation enhances the transcriptional activity. Phosphorylated by HIPK3. Phosphorylated by DYRK2 at Ser-243; this primes the protein for subsequent phosphorylation by GSK3B at Thr-239. Phosphorylated at Thr-239, Ser-243 and Ser-249 by GSK3B; phosphorylation reduces its ability to bind DNA. Phosphorylated by PAK2 at Thr-2, Thr-8, Thr-89, Thr-93 and Thr-286 thereby promoting JUN-mediated cell proliferation and transformation. Phosphorylated by PLK3 following hypoxia or UV irradiation, leading to increase DNA-binding activity. Phosphorylated by VRK1 (PubMed:31527692). {ECO:0000269|PubMed:14739463, ECO:0000269|PubMed:17210646, ECO:0000269|PubMed:17804415, ECO:0000269|PubMed:1846781, ECO:0000269|PubMed:18650425, ECO:0000269|PubMed:21177766, ECO:0000269|PubMed:22307329, ECO:0000269|PubMed:31527692, ECO:0000269|PubMed:8464713, ECO:0000269|PubMed:8855261}.; PTM: Acetylated at Lys-271 by EP300. {ECO:0000269|PubMed:11689449}.
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
protein_family
Jun subfamily
uniprot
proteins
pubmed
10196196
uniprot
proteins
pubmed
10376527
uniprot
proteins
pubmed
10995748
uniprot
proteins
pubmed
11689449
uniprot
proteins
pubmed
12087103
uniprot
proteins
pubmed
12618758
uniprot
proteins
pubmed
14739463
uniprot
proteins
pubmed
15467742
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16478997
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17210646
uniprot
proteins
pubmed
17804415
uniprot
proteins
pubmed
1846781
uniprot
proteins
pubmed
18650425
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20852630
uniprot
proteins
pubmed
21177766
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22083952
uniprot
proteins
pubmed
22307329
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23624934
uniprot
proteins
pubmed
24263171
uniprot
proteins
pubmed
24559171
uniprot
proteins
pubmed
24623306
uniprot
proteins
pubmed
26242913
uniprot
proteins
pubmed
27458189
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
2825349
uniprot
proteins
pubmed
31341047
uniprot
proteins
pubmed
31527692
uniprot
proteins
pubmed
3194415
uniprot
proteins
pubmed
7816143
uniprot
proteins
pubmed
8464713
uniprot
proteins
pubmed
8662824
uniprot
proteins
pubmed
8663478
uniprot
proteins
pubmed
8837781
uniprot
proteins
pubmed
8855261
uniprot
proteins
pubmed
9732876
uniprot
proteins
sequence_length
331
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins