Mthfr
entrez
17769
canonical
uniprot
Q9WU20
canonical
ensembl
ENSMUSG00000029009
resolver
ensp
ENSMUSP00000069774
resolver
ensp
ENSMUSP00000095395
resolver
enst
ENSMUST00000069604
resolver
enst
ENSMUST00000097788
resolver
genesymbol
Mthfr
resolver
uniprot
A2A7F7
resolver
uniprot
Q3UDB2
resolver
uniprot
Q497H7
resolver
uniprot
Q8CDE4
resolver
uniprot_entry
A2A7F7_MOUSE
resolver
uniprot_entry
MTHR_MOUSE
resolver
uniprot_entry
Q3UDB2_MOUSE
resolver
uniprot_entry
Q497H7_MOUSE
resolver
uniprot_sec
Q8CDE4
resolver
activity_regulation
ACTIVITY REGULATION: Allosterically regulated by S-adenosylmethionine (SAM). {ECO:0000250|UniProtKB:P42898}.
uniprot
proteins
amino_acid_sequence
MVNEARGSGSPNPRSEGSSSGSESSKDSSRCSTPSLDPERHERLREKMRRRMDSGDKWFSLEFFPPRTAEGAVNLISRFDRMAAGGPLFVDVTWHPAGDPGSDKETSSMMIASTAVNYCGLETILHMTCCQQRPEEITGHLHRAKQLGLKNIMALRGDPVGDHWEAEEGGFSYATDLVKHIRTEFADYFDICVAGYPRGHPDAESFEDDLKHLKEKVSAGADFIITQLFFEASTFFSFVKACTEIGISCPILPGIFPIQGYTSLRQLVKLSKLEVPQKIKDVIEPIKDNDAAIRNYGIELAVSLCRELLDSGLVPGLHFYTLNREVATMEVLKQLGMWTEDPRRPLPWALSAHPKRREEDVRPIFWASRPKSYIYRTQDWDEFPNGRWGNSSSPAFGELKDYYLFYLKSKSPREELLKMWGEELTSEESVFEVFEHYLSGEPNRHGYRVTCLPWNDEPLAAETSLMKEELLRVNRLGILTINSQPNINAKPSSDPVVGWGPSGGYVFQKAYLEFFTSRETVEALLQVLKTYELRVNYHIVDVKGENITNAPELQPNAVTWGIFPGREIIQPTVVDPISFMFWKDEAFALWIEQWGKLYEEESPSRMIIQYIHDNYFLVNLVDNEFPLDSCLWQVVEDTFELLNRHPTERETQAP
uniprot
proteins
ec_number
1.5.1.53
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine. Represents a key regulatory connection between the folate and methionine cycles. {ECO:0000250|UniProtKB:P42898}.
uniprot
proteins
mass_dalton
74580
uniprot
proteins
pathway_participation
PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion. {ECO:0000250|UniProtKB:P42898}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of an N-terminal serine-rich phosphorylation region increases sensitivity to S-adenosylmethionine and inhibition. {ECO:0000250|UniProtKB:P42898}.
uniprot
proteins
protein_family
Methylenetetrahydrofolate reductase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9680386
uniprot
proteins
sequence_length
654
uniprot
proteins