KLF4
entrez
9314
canonical
uniprot
O43474
canonical
ensembl
ENSG00000136826
resolver
ensp
ENSP00000363804
resolver
genesymbol
KLF4
resolver
genesymbol_syn
EZF
resolver
genesymbol_syn
GKLF
resolver
hgnc
HGNC:6348
resolver
uniprot
B2R8S4
resolver
uniprot
B3KT79
resolver
uniprot
L0R3I6
resolver
uniprot
L0R4N5
resolver
uniprot
P78338
resolver
uniprot
Q5T3J8
resolver
uniprot
Q5T3J9
resolver
uniprot
Q8N717
resolver
uniprot
Q9UNP3
resolver
uniprot_entry
KLF4_HUMAN
resolver
uniprot_sec
B2R8S4
resolver
uniprot_sec
B3KT79
resolver
uniprot_sec
L0R3I6
resolver
uniprot_sec
L0R4N5
resolver
uniprot_sec
P78338
resolver
uniprot_sec
Q5T3J8
resolver
uniprot_sec
Q5T3J9
resolver
uniprot_sec
Q8N717
resolver
uniprot_sec
Q9UNP3
resolver
amino_acid_sequence
MRQPPGESDMAVSDALLPSFSTFASGPAGREKTLRQAGAPNNRWREELSHMKRLPPVLPGRPYDLAAATVATDLESGGAGAACGGSNLAPLPRRETEEFNDLLDLDFILSNSLTHPPESVAATVSSSASASSSSSPSSSGPASAPSTCSFTYPIRAGNDPGVAPGGTGGGLLYGRESAPPPTAPFNLADINDVSPSGGFVAELLRPELDPVYIPPQQPQPPGGGLMGKFVLKASLSAPGSEYGSPSVISVSKGSPDGSHPVVVAPYNGGPPRTCPKIKQEAVSSCTHLGAGPPLSNGHRPAAHDFPLGRQLPSRTTPTLGLEEVLSSRDCHPALPLPPGFHPHPGPNYPSFLPDQMQPQVPPLHYQGQSRGFVARAGEPCVCWPHFGTHGMMLTPPSSPLELMPPGSCMPEEPKPKRGRRSWPRKRTATHTCDYAGCGKTYTKSSHLKAHLRTHTGEKPYHCDWDGCGWKFARSDELTRHYRKHTGHRPFQCQKCDRAFSRSDHLALHMKRHF
uniprot
proteins
function
FUNCTION: Transcription factor; can act both as activator and as repressor. Binds the 5'-CACCC-3' core sequence. Binds to the promoter region of its own gene and can activate its own transcription. Regulates the expression of key transcription factors during embryonic development. Plays an important role in maintaining embryonic stem cells, and in preventing their differentiation. Required for establishing the barrier function of the skin and for postnatal maturation and maintenance of the ocular surface. Involved in the differentiation of epithelial cells and may also function in skeletal and kidney development. Contributes to the down-regulation of p53/TP53 transcription. {ECO:0000269|PubMed:17308127, ECO:0000269|PubMed:20071344}.
uniprot
proteins
mass_dalton
54671
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. 'Lys-48'-linked ubiquitinated and targeted for proteasomal degradation by the SCF(BTRC) E3 ubiquitin-protein ligase complex, thereby negatively regulating cell pluripotency maintenance and embryogenesis. Ubiquitinated in a FBXO32-dependent manner, leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q60793}.; PTM: Polyglutamylated by TTLL1 and TTLL4 at Glu-411, which inhibits KLF4 binding with E3 ligase component BTRC, thereby impeding ubiquitination. Deglutamylated by CCP1 and CCP6; deglutamylation promotes KLF4 ubiquitination. KLF4 glutamylation state plays a critical role in the regulation of its function in cell reprogramming, pluripotency maintenance and embryogenesis. {ECO:0000250|UniProtKB:Q60793}.
uniprot
proteins
protein_family
Krueppel C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
10392904
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17308127
uniprot
proteins
pubmed
17467953
uniprot
proteins
pubmed
18035408
uniprot
proteins
pubmed
18655026
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20071344
uniprot
proteins
pubmed
21654807
uniprot
proteins
pubmed
21746878
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23134681
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
29593216
uniprot
proteins
pubmed
31375868
uniprot
proteins
pubmed
9422764
uniprot
proteins
sequence_length
513
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q60793}. Cytoplasm {ECO:0000250|UniProtKB:Q60793}.
uniprot
proteins