Lap3
entrez
66988
canonical
uniprot
Q9CPY7
canonical
ensembl
ENSMUSG00000039682
resolver
ensp
ENSMUSP00000040222
resolver
genesymbol
Lap3
resolver
genesymbol_syn
Lapep
resolver
uniprot
Q3TFS5
resolver
uniprot
Q4FJV1
resolver
uniprot
Q4FK15
resolver
uniprot
Q99P44
resolver
uniprot
Q9CWN8
resolver
uniprot_entry
AMPL_MOUSE
resolver
uniprot_sec
Q3TFS5
resolver
uniprot_sec
Q4FJV1
resolver
uniprot_sec
Q4FK15
resolver
uniprot_sec
Q99P44
resolver
uniprot_sec
Q9CWN8
resolver
amino_acid_sequence
MYLLPLPAAARVALRRLGVRGLWDRGLSTADMTKGLVLGIYAKDKDDDLPQFTSAGESFNKLVSGKLREMLNISGPPLKAGKTRTFYGLHQDFPSVVVVGLGKRSAGVDDQENWHEGKENIRAAVAAGCRQVQDLELPSVEVDPCGDAQAAAEGAVLGLYEYDDLKQKKKVAVSAKLHGSGDLEAWEKGVLFASGQNLARHLMESPANEMTPTRFAEIIEKNLKSASSKTKVHIRPKSWIEEQEMGSFLSVAKGSEEPPVFLEIHYMGSPNATEAPLVFVGKGITFDSGGISIKASANMDLMRADMGGAATICSAIVSAAKLNLPINIIGLAPLCENMPSGKANKPGDVVRARNGKTIQVDNTDAEGRLILADALCYAHTFNPKVIINAATLTGAMDVALGSGATGVFTNSSWLWNKLFEASVETGDRVWRMPLFEHYTRQVIDCQLADVNNLGKYRSAGACTAAAFLREFVTHTKWAHLDIAGVMTNKDEIPYLRKGMSGRPTRTLIEFLLRFSKDSS
uniprot
proteins
ec_number
3.4.11.1
uniprot
proteins
ec_number
3.4.11.5
uniprot
proteins
ec_number
3.4.13.23
uniprot
proteins
function
FUNCTION: Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides. The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme. For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates. Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status. {ECO:0000250|UniProtKB:P00727}.
uniprot
proteins
mass_dalton
56141
uniprot
proteins
protein_family
Peptidase M17 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
519
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q68FS4}.
uniprot
proteins