Il1rap
entrez
16180
canonical
uniprot
Q61730
canonical
ensembl
ENSMUSG00000022514
resolver
ensp
ENSMUSP00000023156
resolver
ensp
ENSMUSP00000093843
resolver
ensp
ENSMUSP00000128100
resolver
ensp
ENSMUSP00000134202
resolver
ensp
ENSMUSP00000268248
resolver
ensp
ENSMUSP00000268254
resolver
enst
ENSMUST00000166294
resolver
genesymbol
Il1rap
resolver
uniprot
E9Q6I2
resolver
uniprot
Q3UEL3
resolver
uniprot
Q3UVZ1
resolver
uniprot
Q3V2X3
resolver
uniprot
Q8VCB9
resolver
uniprot_entry
E9Q6I2_MOUSE
resolver
uniprot_entry
IL1AP_MOUSE
resolver
uniprot_entry
Q3UEL3_MOUSE
resolver
uniprot_entry
Q3V2X3_MOUSE
resolver
uniprot_sec
Q3UVZ1
resolver
uniprot_sec
Q8VCB9
resolver
amino_acid_sequence
MGLLWYLMSLSFYGILQSHASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKYNYSTAHSSGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSAMRFPVHKMYIEHGIHKITCPNVDGYFPSSVKPSVTWYKGCTEIVDFHNVLPEGMNLSFFIPLVSNNGNYTCVVTYPENGRLFHLTRTVTVKVVGSPKDALPPQIYSPNDRVVYEKEPGEELVIPCKVYFSFIMDSHNEVWWTIDGKKPDDVTVDITINESVSYSSTEDETRTQILSIKKVTPEDLRRNYVCHARNTKGEAEQAAKVKQKVIPPRYTVELACGFGATVFLVVVLIVVYHVYWLEMVLFYRAHFGTDETILDGKEYDIYVSYARNVEEEEFVLLTLRGVLENEFGYKLCIFDRDSLPGGIVTDETLSFIQKSRRLLVVLSPNYVLQGTQALLELKAGLENMASRGNINVILVQYKAVKDMKVKELKRAKTVLTVIKWKGEKSKYPQGRFWKQLQVAMPVKKSPRWSSNDKQGLSYSSLKNV
uniprot
proteins
ec_number
3.2.2.6
uniprot
proteins
function
FUNCTION: Coreceptor for IL1RL2 in the IL-36 signaling system. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (PubMed:25908590). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (By similarity). {ECO:0000250|UniProtKB:Q9NPH3, ECO:0000269|PubMed:11880380, ECO:0000269|PubMed:15986350, ECO:0000269|PubMed:17675517, ECO:0000269|PubMed:18003919, ECO:0000269|PubMed:18450470, ECO:0000269|PubMed:25908590, ECO:0000303|PubMed:21965679}.; FUNCTION: [Isoform 2]: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling. {ECO:0000269|PubMed:15986350, ECO:0000269|PubMed:18450470}.; FUNCTION: [Isoform 3]: Required for Src phosphorylation by IL1B. Required for IL1B-potentiated NMDA-induced calcium influx in neurons acting in cooperation with IL1R1 isoform 2 to mediate Akt kinase activation. {ECO:0000269|PubMed:22159118, ECO:0000269|PubMed:22778412}.
uniprot
proteins
mass_dalton
65741
uniprot
proteins
mutagenesis
MUTAGEN 27; /note="W->A: Reduces affinity for PTPRD."; /evidence="ECO:0000269|PubMed:25908590"; MUTAGEN 30; /note="D->A: Does not affect affinity for PTPRD."; /evidence="ECO:0000269|PubMed:25908590"; MUTAGEN 69..71; /note="IWY->AWA: Abolishes interaction with PTPRD; when associated with 82-A--A-85. Significantly reduces synaptogenesis; when associated with 82-A--A-85."; /evidence="ECO:0000269|PubMed:25908590"; MUTAGEN 82..85; /note="PINF->AINA: Abolishes interaction with PTPRD; when associated with 69-A--A-71 Significantly reduces synaptogenesis; when associated with 82-A--A-85."; /evidence="ECO:0000269|PubMed:25908590"; MUTAGEN 94; /note="K->A: Reduces affinity for PTPRD."; /evidence="ECO:0000269|PubMed:25908590"; MUTAGEN 527..534; /note="KGEKSKYP->AAAAAAAA: Abolishes interaction with MYD88 and IL-1-dependent activation of NF-kappa-B."; /evidence="ECO:0000269|PubMed:11880380
uniprot
proteins
protein_family
Interleukin-1 receptor family
uniprot
proteins
pubmed
10854325
uniprot
proteins
pubmed
11880380
uniprot
proteins
pubmed
12659850
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15986350
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17675517
uniprot
proteins
pubmed
18003919
uniprot
proteins
pubmed
18450470
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19481478
uniprot
proteins
pubmed
20200353
uniprot
proteins
pubmed
21349253
uniprot
proteins
pubmed
21965679
uniprot
proteins
pubmed
22159118
uniprot
proteins
pubmed
22778412
uniprot
proteins
pubmed
25908590
uniprot
proteins
pubmed
7775431
uniprot
proteins
pubmed
9862719
uniprot
proteins
sequence_length
570
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
uniprot
proteins
transmembrane_region
TRANSMEM 368..388; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins