CCN3
entrez
4856
canonical
uniprot
P48745
canonical
ensembl
ENSG00000136999
resolver
ensp
ENSP00000259526
resolver
enst
ENST00000259526
resolver
genesymbol
CCN3
resolver
genesymbol_syn
IGFBP9
resolver
genesymbol_syn
NOV
resolver
genesymbol_syn
NOVH
resolver
hgnc
HGNC:7885
resolver
uniprot
B2R5X7
resolver
uniprot
Q6I9S3
resolver
uniprot
Q96BY5
resolver
uniprot
Q9UDE4
resolver
uniprot_entry
CCN3_HUMAN
resolver
uniprot_sec
B2R5X7
resolver
uniprot_sec
Q6I9S3
resolver
uniprot_sec
Q96BY5
resolver
uniprot_sec
Q9UDE4
resolver
amino_acid_sequence
MQSVQSTSFCLRKQCLCLTFLLLHLLGQVAATQRCPPQCPGRCPATPPTCAPGVRAVLDGCSCCLVCARQRGESCSDLEPCDESSGLYCDRSADPSNQTGICTAVEGDNCVFDGVIYRSGEKFQPSCKFQCTCRDGQIGCVPRCQLDVLLPEPNCPAPRKVEVPGECCEKWICGPDEEDSLGGLTLAAYRPEATLGVEVSDSSVNCIEQTTEWTACSKSCGMGFSTRVTNRNRQCEMLKQTRLCMVRPCEQEPEQPTDKKGKKCLRTKKSLKAIHLQFKNCTSLHTYKPRFCGVCSDGRCCTPHNTKTIQAEFQCSPGQIVKKPVMVIGTCTCHTNCPKNNEAFLQELELKTTRGKM
uniprot
proteins
function
FUNCTION: Immediate-early protein playing a role in various cellular processes including proliferation, adhesion, migration, differentiation and survival (PubMed:12050162, PubMed:12695522, PubMed:15181016, PubMed:15611078, PubMed:21344378). Acts by binding to integrins or membrane receptors such as NOTCH1 (PubMed:12695522, PubMed:15611078, PubMed:21344378). Essential regulator of hematopoietic stem and progenitor cell function (PubMed:17463287). Inhibits myogenic differentiation through the activation of Notch-signaling pathway (PubMed:12050162). Inhibits vascular smooth muscle cells proliferation by increasing expression of cell-cycle regulators such as CDKN2B or CDKN1A independently of TGFB1 signaling (PubMed:20139355). Ligand of integrins ITGAV:ITGB3 and ITGA5:ITGB1, acts directly upon endothelial cells to stimulate pro-angiogenic activities and induces angiogenesis. In endothelial cells, supports cell adhesion, induces directed cell migration (chemotaxis) and promotes cell survival (PubMed:12695522). Also plays a role in cutaneous wound healing acting as integrin receptor ligand. Supports skin fibroblast adhesion through ITGA5:ITGB1 and ITGA6:ITGB1 and induces fibroblast chemotaxis through ITGAV:ITGB5. Seems to enhance bFGF-induced DNA synthesis in fibroblasts (PubMed:15611078). Involved in bone regeneration as a negative regulator (By similarity). Enhances the articular chondrocytic phenotype, whereas it repressed the one representing endochondral ossification (PubMed:21871891). Impairs pancreatic beta-cell function, inhibits beta-cell proliferation and insulin secretion (By similarity). Plays a role as negative regulator of endothelial pro-inflammatory activation reducing monocyte adhesion, its anti-inflammatory effects occur secondary to the inhibition of NF-kappaB signaling pathway (PubMed:21063504). Contributes to the control and coordination of inflammatory processes in atherosclerosis (By similarity). Attenuates inflammatory pain through regulation of IL1B- and TNF-induced MMP9, MMP2 and CCL2 expression. Inhibits MMP9 expression through ITGB1 engagement (PubMed:21871891). Brain osteoanabolic hormone (By similarity). Drives osteogenesis in osteochondral skeletal stem cells (PubMed:38987585). During lactation, maintains the maternal skeleton and viability of offspring (By similarity). {ECO:0000250|UniProtKB:Q64299, ECO:0000269|PubMed:12050162, ECO:0000269|PubMed:12695522, ECO:0000269|PubMed:15181016, ECO:0000269|PubMed:15611078, ECO:0000269|PubMed:17463287, ECO:0000269|PubMed:20139355, ECO:0000269|PubMed:21063504, ECO:0000269|PubMed:21344378, ECO:0000269|PubMed:21871891, ECO:0000269|PubMed:38987585}.
uniprot
proteins
mass_dalton
39162
uniprot
proteins
post_translational_modification
PTM: May be palmitoylated on Cys-244, which is important for extracellular secretion. {ECO:0000250|UniProtKB:Q64299}.
uniprot
proteins
protein_family
CCN family
uniprot
proteins
pubmed
12050162
uniprot
proteins
pubmed
12665631
uniprot
proteins
pubmed
12695522
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15181016
uniprot
proteins
pubmed
15213231
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15611078
uniprot
proteins
pubmed
17463287
uniprot
proteins
pubmed
1756408
uniprot
proteins
pubmed
20139355
uniprot
proteins
pubmed
21063504
uniprot
proteins
pubmed
21344378
uniprot
proteins
pubmed
21871891
uniprot
proteins
pubmed
24722330
uniprot
proteins
pubmed
38987585
uniprot
proteins
pubmed
7520150
uniprot
proteins
pubmed
8622864
uniprot
proteins
pubmed
9927660
uniprot
proteins
sequence_length
357
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q64299}. Cytoplasm {ECO:0000269|PubMed:15181016}. Cell junction, gap junction {ECO:0000269|PubMed:15181016}. Note=Localizes at the gap junction in presence of GJA1. {ECO:0000250|UniProtKB:Q9QZQ5}.
uniprot
proteins