LPAR2
entrez
9170
canonical
uniprot
Q9HBW0
canonical
ensembl
ENSG00000064547
resolver
ensp
ENSP00000384665
resolver
ensp
ENSP00000443256
resolver
ensp
ENSP00000465280
resolver
ensp
ENSP00000532377
resolver
ensp
ENSP00000532378
resolver
ensp
ENSP00000532379
resolver
ensp
ENSP00000532380
resolver
ensp
ENSP00000532381
resolver
ensp
ENSP00000532382
resolver
ensp
ENSP00000532383
resolver
ensp
ENSP00000532384
resolver
ensp
ENSP00000584059
resolver
ensp
ENSP00000584060
resolver
ensp
ENSP00000584061
resolver
ensp
ENSP00000584062
resolver
ensp
ENSP00000584063
resolver
ensp
ENSP00000584064
resolver
ensp
ENSP00000584065
resolver
ensp
ENSP00000584066
resolver
ensp
ENSP00000584067
resolver
ensp
ENSP00000584068
resolver
ensp
ENSP00000584069
resolver
ensp
ENSP00000584070
resolver
ensp
ENSP00000584071
resolver
ensp
ENSP00000584072
resolver
ensp
ENSP00000584073
resolver
ensp
ENSP00000584074
resolver
ensp
ENSP00000584075
resolver
ensp
ENSP00000584076
resolver
ensp
ENSP00000584077
resolver
ensp
ENSP00000584078
resolver
ensp
ENSP00000584079
resolver
ensp
ENSP00000584080
resolver
ensp
ENSP00000584081
resolver
ensp
ENSP00000584082
resolver
ensp
ENSP00000584083
resolver
ensp
ENSP00000584084
resolver
ensp
ENSP00000584085
resolver
ensp
ENSP00000584086
resolver
ensp
ENSP00000584087
resolver
ensp
ENSP00000584088
resolver
ensp
ENSP00000584089
resolver
ensp
ENSP00000627163
resolver
ensp
ENSP00000627164
resolver
ensp
ENSP00000627165
resolver
ensp
ENSP00000627166
resolver
ensp
ENSP00000627167
resolver
enst
ENST00000407877
resolver
enst
ENST00000542587
resolver
enst
ENST00000586703
resolver
enst
ENST00000862318
resolver
enst
ENST00000862319
resolver
enst
ENST00000862320
resolver
enst
ENST00000862321
resolver
enst
ENST00000862322
resolver
enst
ENST00000862323
resolver
enst
ENST00000862324
resolver
enst
ENST00000862325
resolver
enst
ENST00000914000
resolver
enst
ENST00000914001
resolver
enst
ENST00000914002
resolver
enst
ENST00000914003
resolver
enst
ENST00000914004
resolver
enst
ENST00000914005
resolver
enst
ENST00000914006
resolver
enst
ENST00000914007
resolver
enst
ENST00000914008
resolver
enst
ENST00000914009
resolver
enst
ENST00000914010
resolver
enst
ENST00000914011
resolver
enst
ENST00000914012
resolver
enst
ENST00000914013
resolver
enst
ENST00000914014
resolver
enst
ENST00000914015
resolver
enst
ENST00000914016
resolver
enst
ENST00000914017
resolver
enst
ENST00000914018
resolver
enst
ENST00000914019
resolver
enst
ENST00000914020
resolver
enst
ENST00000914021
resolver
enst
ENST00000914022
resolver
enst
ENST00000914023
resolver
enst
ENST00000914024
resolver
enst
ENST00000914025
resolver
enst
ENST00000914026
resolver
enst
ENST00000914027
resolver
enst
ENST00000914028
resolver
enst
ENST00000914029
resolver
enst
ENST00000914030
resolver
enst
ENST00000957104
resolver
enst
ENST00000957105
resolver
enst
ENST00000957106
resolver
enst
ENST00000957107
resolver
enst
ENST00000957108
resolver
genesymbol
LPAR2
resolver
genesymbol_syn
EDG4
resolver
genesymbol_syn
LPA2
resolver
hgnc
HGNC:3168
resolver
uniprot
O00543
resolver
uniprot
O43431
resolver
uniprot_entry
LPAR2_HUMAN
resolver
uniprot_sec
O00543
resolver
uniprot_sec
O43431
resolver
amino_acid_sequence
MGQCYYNETIGFFYNNSGKELSSHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYLLGNLAAADLFAGVAYLFLMFHTGPRTARLSLEGWFLRQGLLDTSLTASVATLLAIAVERHRSVMAVQLHSRLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSRMAPLLSRSYLAVWALSSLLVFLLMVAVYTRIFFYVRRRVQRMAEHVSCHPRYRETTLSLVKTVVIILGAFVVCWTPGQVVLLLDGLGCESCNVLAVEKYFLLLAEANSLVNAAVYSCRDAEMRRTFRRLLCCACLRQSTRESVHYTSSAQGGASTRIMLPENGHPLMDSTL
uniprot
proteins
function
FUNCTION: Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Plays a key role in phospholipase C-beta (PLC-beta) signaling pathway. Stimulates phospholipase C (PLC) activity in a manner that is independent of RALA activation. {ECO:0000269|PubMed:15143197, ECO:0000269|PubMed:19306925}.
uniprot
proteins
mass_dalton
38741
uniprot
proteins
mutagenesis
MUTAGEN 345; /note="D->A: Abolishes interaction with MAGI3."; /evidence="ECO:0000269|PubMed:16904289"; MUTAGEN 346; /note="S->A: Abolishes interaction with MAGI3."; /evidence="ECO:0000269|PubMed:16904289"; MUTAGEN 347; /note="T->A: Does not affect interaction with MAGI3."; /evidence="ECO:0000269|PubMed:16904289"; MUTAGEN 348; /note="L->A: Abolishes interaction with MAGI3."; /evidence="ECO:0000269|PubMed:16904289
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10729222
uniprot
proteins
pubmed
10922489
uniprot
proteins
pubmed
11093753
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15143197
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16904289
uniprot
proteins
pubmed
19306925
uniprot
proteins
pubmed
9525886
uniprot
proteins
sequence_length
348
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell surface {ECO:0000269|PubMed:19306925}. Cell membrane {ECO:0000269|PubMed:19306925}; Multi-pass membrane protein {ECO:0000269|PubMed:19306925}. Note=Prior to LPA treatment found predominantly at the cell surface but in the presence of LPA colocalizes with RALA in the endocytic vesicles.
uniprot
proteins
transmembrane_region
TRANSMEM 31..51; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 67..87; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 101..123; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 144..164; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 186..206; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 240..260; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 277..294; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins