Slc5a2
entrez
246787
canonical
uniprot
Q923I7
canonical
ensembl
ENSMUSG00000030781
resolver
ensp
ENSMUSP00000112597
resolver
enst
ENSMUST00000118169
resolver
genesymbol
Slc5a2
resolver
genesymbol_syn
Sglt2
resolver
uniprot_entry
SC5A2_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Enhanced by the interaction with PDZK1IP1/MAP17. {ECO:0000250|UniProtKB:P31639}.
uniprot
proteins
amino_acid_sequence
MEQHVEAGSELGEQKVLIDNPADILVIAAYFLLVIGVGLWSMFRTNRGTVGGYFLAGRSMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFVPVYLTAGVITMPQYLRKRFGGHRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIALLGITMIYTVTGGLAALMYTDTVQTFVILAGAFILTGYAFHEVGGYSGLFDKYLGAMTSLTVSKDPSVGNISSTCYQPRPDSYHLLRDPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQRCLAGKNLTHIKAGCILCGYLKLMPMFLMVMPGMISRILYPDEVACVVPEVCKRVCGTEVGCSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDKELLLVGRLWVVFIVAVSVAWLPVVQAAQGGQLFDYIQSVSSYLAPPVSAVFVLALFVPRVNEKGAFWGLVGGLLMGLARLIPEFFFGSGSCVRPSACPALFCRVHYLYFAIILFICSGILTLGISLCTAPIPQKHLHRLVFSLRHSKEEREDLDADELEGPAPAPVQNGGQECAMEMEEVQSPAPGLLRRCLLWFCGMSKSGSGSPPPTTEEVAATTRRLEDISEDPRWARVVNLNALLMMTVAVFLWGFYA
uniprot
proteins
function
FUNCTION: Electrogenic Na(+)-coupled sugar symporter that actively transports D-glucose at the plasma membrane, with a Na(+) to sugar coupling ratio of 1:1 (By similarity). Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump (By similarity). Unlike SLC5A1/SGLT1, requires the auxiliary protein PDZK1IP1/MAP17 for full transporter activity (By similarity). Has a primary role in D-glucose reabsorption from glomerular filtrate across the brush border of the early proximal tubules of the kidney (PubMed:20616166). {ECO:0000250|UniProtKB:P31639, ECO:0000269|PubMed:20616166}.
uniprot
proteins
mass_dalton
73008
uniprot
proteins
protein_family
Sodium:solute symporter (SSF) (TC 2.A.21) family
uniprot
proteins
pubmed
11749115
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20616166
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
670
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:20616166}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P31639}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..42; /note="Helical; Name=TM0"; /evidence="ECO:0000250|UniProtKB:P31639"; TRANSMEM 62..83; /note="Helical; Name=TM1"; /evidence="ECO:0000250|UniProtKB:P31639"; TRANSMEM 92..112; /note="Helical; Name=TM2"; /evidence="ECO:0000250|UniProtKB:P31639"; TRANSMEM 135..164; /note="Helical; Name=TM3"; /evidence="ECO:0000250|UniProtKB:P31639"; TRANSMEM 172..193; /note="Helical; Name=TM4"; /evidence="ECO:0000250|UniProtKB:P31639"; TRANSMEM 194..215; /note="Helical; Name=TM5"; /evidence="ECO:0000250|UniProtKB:P31639"; TRANSMEM 274..293; /note="Helical; Name=TM6"; /evidence="ECO:0000250|UniProtKB:P31639"; TRANSMEM 308..329; /note="Helical; Name=TM7"; /evidence="ECO:0000250|UniProtKB:P31639"; TRANSMEM 374..404; /note="Helical; Name=TM8"; /evidence="ECO:0000250|UniProtKB:P31639"; TRANSMEM 423..444; /note="Helical; Name=TM9"; /evidence="ECO:0000250|UniProtKB:P31639"; TRANSMEM 450..475; /note="Helical; Name=TM10"; /evidence="ECO:0000250|UniProtKB:P31639"; TRANSMEM 481..503; /note="Helical; Name=TM11"; /evidence="ECO:0000250|UniProtKB:P31639"; TRANSMEM 522..545; /note="Helical; Name=TM12"; /evidence="ECO:0000250|UniProtKB:P31639"; TRANSMEM 650..668; /note="Helical; Name=TM13"; /evidence="ECO:0000250|UniProtKB:P31639
uniprot
proteins