Ripk4
entrez
72388
canonical
uniprot
Q9ERK0
canonical
ensembl
ENSMUSG00000005251
resolver
ensp
ENSMUSP00000019386
resolver
enst
ENSMUST00000019386
resolver
genesymbol
Ripk4
resolver
genesymbol_syn
Ankrd3
resolver
genesymbol_syn
Pkk
resolver
uniprot
Q3UM04
resolver
uniprot_entry
RIPK4_MOUSE
resolver
uniprot_sec
Q3UM04
resolver
amino_acid_sequence
MEGEGRGRWALGLLRTFDAGEFAGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRYILPVYGICQEPVGLVMEYMETGSLEKLLASEPLPWDLRFRIVHETAVGMNFLHCMSPPLLHLDLKPANILLDAHYHVKISDFGLAKCNGMSHSHDLSMDGLFGTIAYLPPERIREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMMKVVKGHRPELPPICRPRPRACASLIGLMQRCWHADPQVRPTFQEITSETEDLCEKPDEEVKDLAHEPGEKSSLESKSEARPESSRLKRASAPPFDNDCSLSELLSQLDSGISQTLEGPEELSRSSSECKLPSSSSGKRLSGVSSVDSAFSSRGSLSLSFEREASTGDLGPTDIQKKKLVDAIISGDTSRLMKILQPQDVDLVLDSSASLLHLAVEAGQEECVKWLLLNNANPNLTNRKGSTPLHMAVERKGRGIVELLLARKTSVNAKDEDQWTALHFAAQNGDEASTRLLLEKNASVNEVDFEGRTPMHVACQHGQENIVRTLLRRGVDVGLQGKDAWLPLHYAAWQGHLPIVKLLAKQPGVSVNAQTLDGRTPLHLAAQRGHYRVARILIDLCSDVNICSLQAQTPLHVAAETGHTSTARLLLHRGAGKEALTSEGYTALHLAAQNGHLATVKLLIEEKADVMARGPLNQTALHLAAARGHSEVVEELVSADLIDLSDEQGLSALHLAAQGRHSQTVETLLKHGAHINLQSLKFQGGQSSAATLLRRSKT
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine protein kinase (PubMed:28507225). Required for embryonic skin development and correct skin homeostasis in adults, via phosphorylation of PKP1 and subsequent promotion of keratinocyte differentiation and cell adhesion (PubMed:28507225). It is a direct transcriptional target of TP63 (PubMed:22197488). Plays a role in NF-kappa-B activation (PubMed:12446564). {ECO:0000269|PubMed:12446564, ECO:0000269|PubMed:22197488, ECO:0000269|PubMed:28507225}.
uniprot
proteins
mass_dalton
86613
uniprot
proteins
post_translational_modification
PTM: May be phosphorylated by MAP3K2 and MAP3K3. {ECO:0000269|PubMed:11278382, ECO:0000269|PubMed:12676934}.; PTM: Proteolytically cleaved by during Fas-induced apoptosis. Cleavage at Asp-342 and Asp-380. {ECO:0000269|PubMed:12446564}.; PTM: Polyubiquitinated with 'Lys-48' and 'Lys-63'-linked chains by BIRC2/c-IAP1 and BIRC3/c-IAP2, leading to activation of NF-kappa-B. {ECO:0000250}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
TKL Ser/Thr protein kinase family
uniprot
proteins
pubmed
11278382
uniprot
proteins
pubmed
12446564
uniprot
proteins
pubmed
12676934
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
22197488
uniprot
proteins
pubmed
28507225
uniprot
proteins
sequence_length
786
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Note=At steady state, a minor portion of this protein is membrane-associated. The major portion is cytoplasmic.
uniprot
proteins