TUNAR
entrez
100507043
canonical
uniprot
A0A1B0GTB2
canonical
ensembl
ENSG00000250366
resolver
ensp
ENSP00000489624
resolver
ensp
ENSP00000490254
resolver
ensp
ENSP00000498192
resolver
ensp
ENSP00000504015
resolver
ensp
ENSP00000510004
resolver
ensp
ENSP00000587074
resolver
enst
ENST00000503525
resolver
enst
ENST00000504119
resolver
enst
ENST00000554321
resolver
enst
ENST00000678517
resolver
enst
ENST00000687554
resolver
enst
ENST00000917015
resolver
genesymbol
TUNAR
resolver
hgnc
HGNC:44088
resolver
uniprot
A0A1B0GUV0
resolver
uniprot
A0A7I2V4K3
resolver
uniprot_entry
A0A7I2V4K3_HUMAN
resolver
uniprot_entry
TUNAR_HUMAN
resolver
uniprot_sec
A0A1B0GUV0
resolver
amino_acid_sequence
MVITSENDEDRGGQEKESKEESVLAMLGIIGTILNLIVIIFVYIYTTL
uniprot
proteins
function
FUNCTION: In neurons, plays a role in the regulation of intracellular Ca(2+), possibly by acting as an activator of ATP2A2/SERCA2, thus increasing the efficiency with which Ca(2+) is removed from the cytoplasm (By similarity). Inhibits differentiation of embryonic stem cells into neurons and inhibits neurite outgrowth, likely as a result of its role in intracellular Ca(2+) regulation (By similarity). In pancreatic beta cells, lowers Ca(2+) levels in the endoplasmic reticulum and enhances glucose-stimulated insulin secretion (PubMed:34513312). {ECO:0000250|UniProtKB:A0A1B0GQX2, ECO:0000269|PubMed:34513312}.
uniprot
proteins
mass_dalton
5360
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
34513312
uniprot
proteins
sequence_length
48
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:34513312}; Single-pass membrane protein {ECO:0000255}. Extracellular vesicle membrane {ECO:0000250|UniProtKB:A0A1B0GQX2}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 24..44; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins