RNF149
entrez
284996
canonical
uniprot
Q8NC42
canonical
ensembl
ENSG00000163162
resolver
ensp
ENSP00000295317
resolver
ensp
ENSP00000660177
resolver
ensp
ENSP00000756271
resolver
ensp
ENSP00000779451
resolver
enst
ENST00000295317
resolver
genesymbol
RNF149
resolver
genesymbol_syn
DNAPTP2
resolver
hgnc
HGNC:23137
resolver
uniprot
Q53S14
resolver
uniprot
Q8N5I8
resolver
uniprot
Q8NBY5
resolver
uniprot
Q8WUU3
resolver
uniprot_entry
RN149_HUMAN
resolver
uniprot_sec
Q53S14
resolver
uniprot_sec
Q8N5I8
resolver
uniprot_sec
Q8NBY5
resolver
uniprot_sec
Q8WUU3
resolver
amino_acid_sequence
MAWRRREASVGARGVLALALLALALCVPGARGRALEWFSAVVNIEYVDPQTNLTVWSVSESGRFGDSSPKEGAHGLVGVPWAPGGDLEGCAPDTRFFVPEPGGRGAAPWVALVARGGCTFKDKVLVAARRNASAVVLYNEERYGNITLPMSHAGTGNIVVIMISYPKGREILELVQKGIPVTMTIGVGTRHVQEFISGQSVVFVAIAFITMMIISLAWLIFYYIQRFLYTGSQIGSQSHRKETKKVIGQLLLHTVKHGEKGIDVDAENCAVCIENFKVKDIIRILPCKHIFHRICIDPWLLDHRTCPMCKLDVIKALGYWGEPGDVQEMPAPESPPGRDPAANLSLALPDDDGSDDSSPPSASPAESEPQCDPSFKGDAGENTALLEAGRSDSRHGGPIS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase. Ubiquitinates BRAF, inducing its proteasomal degradation. {ECO:0000269|PubMed:22628551}.
uniprot
proteins
mass_dalton
43165
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
22628551
uniprot
proteins
sequence_length
400
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 201..221; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins