RNF152
entrez
220441
canonical
uniprot
Q8N8N0
canonical
ensembl
ENSG00000176641
resolver
ensp
ENSP00000316628
resolver
ensp
ENSP00000543324
resolver
ensp
ENSP00000543325
resolver
ensp
ENSP00000543326
resolver
ensp
ENSP00000543327
resolver
ensp
ENSP00000543328
resolver
ensp
ENSP00000543329
resolver
ensp
ENSP00000543330
resolver
ensp
ENSP00000543331
resolver
ensp
ENSP00000543332
resolver
ensp
ENSP00000543333
resolver
ensp
ENSP00000543334
resolver
ensp
ENSP00000543335
resolver
ensp
ENSP00000543336
resolver
ensp
ENSP00000543337
resolver
ensp
ENSP00000543338
resolver
ensp
ENSP00000543339
resolver
ensp
ENSP00000639196
resolver
ensp
ENSP00000639197
resolver
ensp
ENSP00000639198
resolver
ensp
ENSP00000639199
resolver
ensp
ENSP00000639200
resolver
ensp
ENSP00000639201
resolver
ensp
ENSP00000639202
resolver
ensp
ENSP00000639203
resolver
enst
ENST00000312828
resolver
enst
ENST00000873265
resolver
enst
ENST00000873266
resolver
enst
ENST00000873267
resolver
enst
ENST00000873268
resolver
enst
ENST00000873269
resolver
enst
ENST00000873270
resolver
enst
ENST00000873271
resolver
enst
ENST00000873272
resolver
enst
ENST00000873273
resolver
enst
ENST00000873274
resolver
enst
ENST00000873275
resolver
enst
ENST00000873276
resolver
enst
ENST00000873277
resolver
enst
ENST00000873278
resolver
enst
ENST00000873279
resolver
enst
ENST00000873280
resolver
enst
ENST00000969137
resolver
enst
ENST00000969138
resolver
enst
ENST00000969139
resolver
enst
ENST00000969140
resolver
enst
ENST00000969141
resolver
enst
ENST00000969142
resolver
enst
ENST00000969143
resolver
enst
ENST00000969144
resolver
genesymbol
RNF152
resolver
hgnc
HGNC:26811
resolver
uniprot
B3KV99
resolver
uniprot
Q52LA4
resolver
uniprot_entry
RN152_HUMAN
resolver
uniprot_sec
B3KV99
resolver
uniprot_sec
Q52LA4
resolver
amino_acid_sequence
METLSQDSLLECQICFNYYSPRRRPKLLDCKHTCCSVCLQQMRTSQKDVRCPWCRGVTKLPPGFSVSQLPDDPEVLAVIAIPHTSEHTPVFIKLPSNGCYMLPLPISKERALLPGDMGCRLLPGSQQKSVTVVTIPAEQQPLQGGAPQEAVEEEQDRRGVVKSSTWSGVCTVILVACVLVFLLGIVLHNMSCISKRFTVISCG
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that acts as a negative regulator of mTORC1 signaling by mediating ubiquitination of RagA/RRAGA and RHEB (PubMed:25936802, PubMed:30514904). Catalyzes 'Lys-63'-linked polyubiquitination of RagA/RRAGA in response to amino acid starvation, thereby regulating mTORC1 signaling (PubMed:25936802). Also mediates monoubiquitination of RHEB, promoting its association with the TSC-TBC complex and subsequent inhibition (PubMed:30514904). Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation (PubMed:21203937). Induces apoptosis when overexpressed (PubMed:21203937). {ECO:0000269|PubMed:21203937, ECO:0000269|PubMed:25936802, ECO:0000269|PubMed:30514904}.
uniprot
proteins
mass_dalton
22357
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:25936802, ECO:0000269|PubMed:30514904}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Autoubiquitinated in vitro, leading to its degradation by the proteasome (Probable). {ECO:0000305|PubMed:21203937}.
uniprot
proteins
protein_family
RNF152 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
21203937
uniprot
proteins
pubmed
25936802
uniprot
proteins
pubmed
30514904
uniprot
proteins
sequence_length
203
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:25936802, ECO:0000305|PubMed:21203937}; Single-pass membrane protein {ECO:0000269|PubMed:25936802, ECO:0000305|PubMed:21203937}.
uniprot
proteins
transmembrane_region
TRANSMEM 167..187; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins