SUN5
entrez
140732
canonical
uniprot
Q8TC36
canonical
ensembl
ENSG00000167098
resolver
ensp
ENSP00000348496
resolver
ensp
ENSP00000364673
resolver
enst
ENST00000356173
resolver
enst
ENST00000375523
resolver
genesymbol
SUN5
resolver
genesymbol_syn
SPAG4L
resolver
genesymbol_syn
TSARG4
resolver
hgnc
HGNC:16252
resolver
uniprot
A0A384MDU5
resolver
uniprot
A6NJ82
resolver
uniprot
A9Z1W8
resolver
uniprot
Q5T9R0
resolver
uniprot_entry
A0A384MDU5_HUMAN
resolver
uniprot_entry
A9Z1W8_HUMAN
resolver
uniprot_entry
SUN5_HUMAN
resolver
uniprot_sec
A6NJ82
resolver
uniprot_sec
Q5T9R0
resolver
amino_acid_sequence
MPRSSRSPGDPGALLEDVAHNPRPRRIAQRGRNTSRMAEDTSPNMNDNILLPVRNNDQALGLTQCMLGCVSWFTCFACSLRTQAQQVLFNTCRCKLLCQKLMEKTGILLLCAFGFWMFSIHLPSKMKVWQDDSINGPLQSLRLYQEKVRHHSGEIQDLRGSMNQLIAKLQEMEAMSDEQKMAQKIMKMIHGDYIEKPDFALKSIGASIDFEHTSVTYNHEKAHSYWNWIQLWNYAQPPDVILEPNVTPGNCWAFEGDRGQVTIQLAQKVYLSNLTLQHIPKTISLSGSLDTAPKDFVIYGMEGSPKEEVFLGAFQFQPENIIQMFPLQNQPARAFSAVKVKISSNWGNPGFTCLYRVRVHGSVAPPREQPHQNPYPKRD
uniprot
proteins
disease_involvement
DISEASE: Spermatogenic failure 16 (SPGF16) [MIM:617187]: An infertility disorder caused by spermatogenesis defects and characterized by abnormally shaped spermatozoa in the semen of affected individuals. Most spermatozoa are made up of headless tails, while a small proportion has an abnormal head-tail junction. A few spermatozoa are made up of tailless heads. {ECO:0000269|PubMed:27640305, ECO:0000269|PubMed:28541472, ECO:0000269|PubMed:28945193, ECO:0000269|PubMed:29298896}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Required for male fertility (PubMed:38870534). Plays an essential role in maintenance of sperm head-to-tail attachment during late stages of spermiogenesis, via promoting secure attachment of the nuclear envelope to the flagellum coupling apparatus (Probable) (PubMed:38870534). Component of the LMNB1/SUN5/SEPT12 bridge that connects the sperm proximal centriole to the implantation fossa, the bridge functions to prevent detachment of the proximal centriole from the posterior nucleus during spermiogenesis (PubMed:38870534). Required for localization of SEPT12 at the implantation fossa of sperm cells during spermiogenesis (By similarity). {ECO:0000250|UniProtKB:Q9DA32, ECO:0000269|PubMed:38870534, ECO:0000305|PubMed:28945193}.
uniprot
proteins
mass_dalton
43081
uniprot
proteins
post_translational_modification
PTM: Highly glycosylated in the Golgi apparatus during spermiogenesis. {ECO:0000250|UniProtKB:Q9DA32}.
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12621555
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21711156
uniprot
proteins
pubmed
27640305
uniprot
proteins
pubmed
27912045
uniprot
proteins
pubmed
28541472
uniprot
proteins
pubmed
28945193
uniprot
proteins
pubmed
29298896
uniprot
proteins
pubmed
38870534
uniprot
proteins
sequence_length
379
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000305|PubMed:27640305}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9DA32}. Golgi apparatus {ECO:0000250|UniProtKB:Q9DA32}. Note=During spermiogenesis, traffics through the Golgi apparatus before reaching the round spermatid inner membrane of the nuclear envelope and later migrates to the coupling apparatus of the sperm during sperm head elongation and differentiation. Expressed at the sperm implantation fossa in spermatids during spermiogenesis. In mature spermatozoa, is localized to the coupling apparatus of the sperm head and tail in the implementation fossa (By similarity). Expressed at the neck region in mature sperm (By similarity). {ECO:0000250|UniProtKB:Q9DA32, ECO:0000305|PubMed:27640305}.
uniprot
proteins
transmembrane_region
TRANSMEM 106..122; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins