Tp63
entrez
22061
canonical
uniprot
O88898
canonical
ensembl
ENSMUSG00000022510
resolver
ensp
ENSMUSP00000038117
resolver
ensp
ENSMUSP00000067005
resolver
ensp
ENSMUSP00000110960
resolver
ensp
ENSMUSP00000110961
resolver
ensp
ENSMUSP00000110963
resolver
ensp
ENSMUSP00000110965
resolver
enst
ENSMUST00000115305
resolver
enst
ENSMUST00000115306
resolver
genesymbol
Tp63
resolver
genesymbol
Trp63
resolver
genesymbol_syn
P63
resolver
genesymbol_syn
P73l
resolver
genesymbol_syn
Tp73l
resolver
genesymbol_syn
Trp63
resolver
uniprot
F7ASJ6
resolver
uniprot
F7ASK5
resolver
uniprot
O88897
resolver
uniprot
O88899
resolver
uniprot
O89097
resolver
uniprot
Q3UVI3
resolver
uniprot
Q569E5
resolver
uniprot
Q5CZX0
resolver
uniprot
Q8C826
resolver
uniprot
Q9QWY9
resolver
uniprot
Q9QWZ0
resolver
uniprot_entry
F7ASJ6_MOUSE
resolver
uniprot_entry
F7ASK5_MOUSE
resolver
uniprot_entry
P63_MOUSE
resolver
uniprot_entry
Q3UVI3_MOUSE
resolver
uniprot_entry
Q569E5_MOUSE
resolver
uniprot_entry
Q5CZX0_MOUSE
resolver
uniprot_sec
O88897
resolver
uniprot_sec
O88899
resolver
uniprot_sec
O89097
resolver
uniprot_sec
Q8C826
resolver
uniprot_sec
Q9QWY9
resolver
uniprot_sec
Q9QWZ0
resolver
amino_acid_sequence
MNFETSRCATLQYCPDPYIQRFIETPAHFSWKESYYRSAMSQSTQTSEFLSPEVFQHIWDFLEQPICSVQPIELNFVDEPSENGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIRKQQVSDSAKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSMQSQSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTMPEGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDHRQLHDFSSPPHLLRTPSGASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFDMDSRRNKQQRIKEEGE
uniprot
proteins
function
FUNCTION: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Activates transcription of the p21 promoter (By similarity). Activates RIPK4 transcription. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Binds to an upstream regulatory region of the DSG1 gene and promotes transcription (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q9H3D4, ECO:0000269|PubMed:10227293, ECO:0000269|PubMed:10227294, ECO:0000269|PubMed:11932750, ECO:0000269|PubMed:14729569, ECO:0000269|PubMed:22197488}.
uniprot
proteins
mass_dalton
76789
uniprot
proteins
mutagenesis
MUTAGEN 543; /note="Y->F: Abolishes interaction with WWP1."; /evidence="ECO:0000269|PubMed:18806757"; MUTAGEN 647; /note="R->C: Heterozygous mutant mice have reduced fertility, reduced ovary size and accelerated oocyte loss via apoptosis."; /evidence="ECO:0000269|PubMed:36856110
uniprot
proteins
post_translational_modification
PTM: May be sumoylated. {ECO:0000250}.; PTM: Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein. {ECO:0000269|PubMed:18806757}.
uniprot
proteins
protein_family
P53 family
uniprot
proteins
pubmed
10227293
uniprot
proteins
pubmed
10227294
uniprot
proteins
pubmed
11932750
uniprot
proteins
pubmed
14729569
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18806757
uniprot
proteins
pubmed
22197488
uniprot
proteins
pubmed
32758484
uniprot
proteins
pubmed
36856110
uniprot
proteins
pubmed
9703973
uniprot
proteins
pubmed
9774969
uniprot
proteins
sequence_length
680
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14729569}.
uniprot
proteins