Q460M5
uniprot
Q460M5
canonical
amino_acid_sequence
METLLGGLLAFGMAFAVVDACPKYCVCQNLSESLGTLCPSKGLLFVPPDIDRRTVELRLGGNFIIHIGRQDFANMTGLVDLTLSRNTISHIQPFSFLDLESLRSLHLDSNRLPSLGEDTLRGLVNLQHLIVNNNQLGGIADDAFEDFLLTLEDLDLSYNNLHGLPWDSVRRMVNLHQLSLDHNLLDHIAEGTFADLQKLARLDLTSNRLQKLPPDPIFARSQASLLTATPFAPPLSFSFGGNPLHCNCELLWLRRLERDDDLKTCGSPGGLKGRYFWHIREEEFVCEPPLITQHTHKLLVLEGQAATLKCKAIGDPSPLIHWVAPDDRLVGNSSRTAVYDNGTLDILITTSQDSGPFTCIAANAAGEATATVEVSIVQLPHLSNSTSRMAPPKSRLSDITGSSKTSRGGGGSGAGEPPKSTPERAVLVSDVTTTSALVKWSVSKSAPRVKMYQLQYNCSDDEVLIYRMIPASNKAFVVNNLVSGTGYDLCVLAMWDDTATTLTATNIVGCAQFFTKADYPQCQSMHSQILGGTMILVIGGIIVATLLVFIVILMVRYKVCNHDAPGKMAAATVSNVYSQTNGAQPPPLGGMPVGQLPQAPPKVVVRNELMDFSTSLARACDSSSSSSLGSGEAAGLSRGPWRLPPPAPRPKPSLDRLMGAFASLDLKSQRKEELLDSRTPAGRGAGTSARGHHSDREPLLGPPATRARSLLPLPLEGKAKRSHSFDMGDFAAAAAAAPGGYSPPRRVSNIWTKRSLSVNGMLLPFEENDLVGARGTFGSSEWVMESTV
uniprot
proteins
function
FUNCTION: Promotes neurite outgrowth in hippocampal neurons. Enhances the cell surface expression of GRIN1 and GRIN2A NMDA receptor subunits. May play a role in redistributing DLG4 to the cell periphery (By similarity). {ECO:0000250, ECO:0000269|PubMed:16495444, ECO:0000269|PubMed:18585462}.
uniprot
proteins
mass_dalton
84917
uniprot
proteins
mutagenesis
MUTAGEN 785..788; /note="Missing: Severe decrease in cell surface expression. Loss of neurite outgrowth promotion. Loss of DLG4-binding. No effect on LRFN1-,LRFN3-, and LRFN4-binding, nor on homomeric interactions."; /evidence="ECO:0000269|PubMed:16495444, ECO:0000269|PubMed:18227064
uniprot
proteins
protein_family
LRFN family
uniprot
proteins
pubmed
16495444
uniprot
proteins
pubmed
18227064
uniprot
proteins
pubmed
18585462
uniprot
proteins
sequence_length
788
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:16495444}; Single-pass type I membrane protein {ECO:0000269|PubMed:16495444}. Synapse {ECO:0000269|PubMed:16495444}. Postsynaptic cell membrane {ECO:0000269|PubMed:16495444}.
uniprot
proteins
transmembrane_region
TRANSMEM 535..555; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins