Rad51b
entrez
19363
canonical
uniprot
O35719
canonical
ensembl
ENSMUSG00000059060
resolver
ensp
ENSMUSP00000078490
resolver
ensp
ENSMUSP00000128357
resolver
ensp
ENSMUSP00000345964
resolver
genesymbol
Rad51b
resolver
genesymbol_syn
Rad51l1
resolver
genesymbol_syn
Rec2
resolver
uniprot
Q8BSH6
resolver
uniprot
Q9D555
resolver
uniprot_entry
RA51B_MOUSE
resolver
uniprot_sec
Q8BSH6
resolver
uniprot_sec
Q9D555
resolver
amino_acid_sequence
MSSKKLRRVGLSPELCDRLSRYQIVNCQHFLSLSPLELMKVTGLSYRGVHELLHTVSKACAPQMQTAYELKTRRSAHLSPAFLSTTLCALDEALHGGVPCGSLTEITGPPGCGKTQFCIMMSVLATLPTSLGGLEGAVVYIDTESAFTAERLVEIAESRFPQYFNTEEKLLLTSSRVHLCRELTCEGLLQRLESLEEEIISKGVKLVIVDSIASVVRKEFDPKLQGNIKERNKFLGKGASLLKYLAGEFSIPVILTNQITTHLSGALPSQADLVSPADDLSLSEGTSGSSCLVAALGNTWGHCVNTRLILQYLDSERRQILIAKSPLAAFTSFVYTIKGEGLVLQGHERP
uniprot
proteins
function
FUNCTION: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. {ECO:0000250|UniProtKB:O15315}.
uniprot
proteins
mass_dalton
38152
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues by BCR-ABL. {ECO:0000250|UniProtKB:O15315}.
uniprot
proteins
protein_family
RAD51 subfamily
uniprot
proteins
protein_family
RecA family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
9207106
uniprot
proteins
sequence_length
350
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O15315}.
uniprot
proteins