SLC6A12
entrez
6539
canonical
uniprot
P48065
canonical
ensembl
ENSG00000111181
resolver
ensp
ENSP00000352702
resolver
ensp
ENSP00000380464
resolver
ensp
ENSP00000399136
resolver
ensp
ENSP00000444268
resolver
ensp
ENSP00000508194
resolver
ensp
ENSP00000525804
resolver
ensp
ENSP00000525805
resolver
ensp
ENSP00000525806
resolver
ensp
ENSP00000525807
resolver
ensp
ENSP00000525808
resolver
ensp
ENSP00000525809
resolver
ensp
ENSP00000525812
resolver
ensp
ENSP00000525813
resolver
ensp
ENSP00000525814
resolver
ensp
ENSP00000525815
resolver
ensp
ENSP00000525816
resolver
ensp
ENSP00000777211
resolver
ensp
ENSP00000777212
resolver
ensp
ENSP00000777213
resolver
ensp
ENSP00000777217
resolver
enst
ENST00000359674
resolver
enst
ENST00000397296
resolver
enst
ENST00000424061
resolver
enst
ENST00000536824
resolver
enst
ENST00000684302
resolver
enst
ENST00000855745
resolver
enst
ENST00000855746
resolver
enst
ENST00000855747
resolver
enst
ENST00000855748
resolver
enst
ENST00000855749
resolver
enst
ENST00000855750
resolver
enst
ENST00000855753
resolver
enst
ENST00000855754
resolver
enst
ENST00000855755
resolver
enst
ENST00000855756
resolver
enst
ENST00000855757
resolver
genesymbol
SLC6A12
resolver
genesymbol_syn
BGT1
resolver
hgnc
HGNC:11045
resolver
uniprot
A0AV52
resolver
uniprot
B2R992
resolver
uniprot
D3DUN8
resolver
uniprot_entry
S6A12_HUMAN
resolver
uniprot_sec
A0AV52
resolver
uniprot_sec
B2R992
resolver
uniprot_sec
D3DUN8
resolver
amino_acid_sequence
MDGKVAVQECGPPAVSWVPEEGEKLDQEDEDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFVCGIPVFFLEVALGQYTSQGSVTAWRKICPLFQGIGLASVVIESYLNVYYIIILAWALFYLFSSFTSELPWTTCNNFWNTEHCTDFLNHSGAGTVTPFENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWVICYFCIWKGVKSTGKVVYFTATFPYLMLVILLIRGVTLPGAYQGIIYYLKPDLFRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYKDCIALCFLNSATSFVAGFVVFSILGFMSQEQGVPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLIFLGLDSQFVCVECLVTASIDMFPRQLRKSGRRELLILTIAVMCYLIGLFLVTEGGMYIFQLFDYYASSGICLLFLSLFEVVCISWVYGADRFYDNIEDMIGYRPWPLVKISWLFLTPGLCLATFLFSLSKYTPLKYNNVYVYPPWGYSIGWFLALSSMVCVPLFVVITLLKTRGPFRKRLRQLITPDSSLPQPKQHPCLDGSAGRNFGPSPTREGLIAGEKETHL
uniprot
proteins
function
FUNCTION: Transporter that mediates cellular uptake of betaine and GABA in a sodium- and chloride-dependent process (PubMed:7589472). May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation. Probably also involved in renal and hepatic osmotic regulation (By similarity). {ECO:0000250|UniProtKB:P31651, ECO:0000269|PubMed:7589472}.
uniprot
proteins
mass_dalton
69368
uniprot
proteins
protein_family
SLC6A12 subfamily
uniprot
proteins
protein_family
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
7589472
uniprot
proteins
pubmed
7861179
uniprot
proteins
sequence_length
614
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000250|UniProtKB:P31651}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:P31651}; Multi-pass membrane protein {ECO:0000255}. Note=In kidney, locates in basolateral membranes of renal medulla. In liver, locates in hepatocytes cell membrane. {ECO:0000250|UniProtKB:P31651}.
uniprot
proteins
transmembrane_region
TRANSMEM 45..65; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 73..92; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 117..137; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 211..229; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 238..255; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 291..308; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 320..341; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 374..393; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 423..441; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 458..478; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 499..518; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 538..556; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins