ENTPD3
entrez
956
canonical
uniprot
O75355
canonical
ensembl
ENSG00000168032
resolver
ensp
ENSP00000301825
resolver
ensp
ENSP00000401565
resolver
ensp
ENSP00000702204
resolver
ensp
ENSP00000792292
resolver
genesymbol
ENTPD3
resolver
genesymbol_syn
CD39L3
resolver
hgnc
HGNC:3365
resolver
uniprot
B2R8D0
resolver
uniprot
G5E9N0
resolver
uniprot
O60495
resolver
uniprot
Q8N6K2
resolver
uniprot_entry
ENTP3_HUMAN
resolver
uniprot_sec
B2R8D0
resolver
uniprot_sec
G5E9N0
resolver
uniprot_sec
O60495
resolver
uniprot_sec
Q8N6K2
resolver
activity_regulation
ACTIVITY REGULATION: ADP hydrolase activity is lost of about 50% with 1 mM NaN3, and 75% with 20 mM (PubMed:9675246). The ATP hydrolase activity is slightly less sensitive to inhibition at all azide concentrations tested (PubMed:9675246). ADP hydrolase activity is inhibited by cibacron blue with an IC(50) value of 1.5 uM (PubMed:10231536). Approximately 30% of the ATP hydrolase activity and 50% of the ADP hydrolase activity are inhibited by 1 mM azide (PubMed:10231536). {ECO:0000269|PubMed:10231536, ECO:0000269|PubMed:9675246}.
uniprot
proteins
amino_acid_sequence
MFTVLTRQPCEQAGLKALYRTPTIIALVVLLVSIVVLVSITVIQIHKQEVLPPGLKYGIVLDAGSSRTTVYVYQWPAEKENNTGVVSQTFKCSVKGSGISSYGNNPQDVPRAFEECMQKVKGQVPSHLHGSTPIHLGATAGMRLLRLQNETAANEVLESIQSYFKSQPFDFRGAQIISGQEEGVYGWITANYLMGNFLEKNLWHMWVHPHGVETTGALDLGGASTQISFVAGEKMDLNTSDIMQVSLYGYVYTLYTHSFQCYGRNEAEKKFLAMLLQNSPTKNHLTNPCYPRDYSISFTMGHVFDSLCTVDQRPESYNPNDVITFEGTGDPSLCKEKVASIFDFKACHDQETCSFDGVYQPKIKGPFVAFAGFYYTASALNLSGSFSLDTFNSSTWNFCSQNWSQLPLLLPKFDEVYARSYCFSANYIYHLFVNGYKFTEETWPQIHFEKEVGNSSIAWSLGYMLSLTNQIPAESPLIRLPIEPPVFVGTLAFFTAAALLCLAFLAYLCSATRRKRHSEHAFDHAVDSD
uniprot
proteins
ec_number
3.6.1.5
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of nucleoside triphosphates (NTPs) and diphosphates (NDPs) (PubMed:10231536, PubMed:11300774, PubMed:15966724, PubMed:9675246). The enzyme sequentially removes phosphate groups in two successive steps, converting NTPs to nucleoside monophosphates (NMPs) via NDP intermediates (PubMed:10231536, PubMed:11300774, PubMed:15966724, PubMed:9675246). This activity contributes to the regulation of extracellular levels of nucleotides (PubMed:10231536, PubMed:11300774, PubMed:15966724, PubMed:9675246). Has a preference for the hydrolysis of ATP (PubMed:10231536). Does not hydrolyzes AMP (PubMed:9675246). {ECO:0000269|PubMed:10231536, ECO:0000269|PubMed:11300774, ECO:0000269|PubMed:15966724, ECO:0000269|PubMed:9675246}.
uniprot
proteins
mass_dalton
59105
uniprot
proteins
mutagenesis
MUTAGEN 67; /note="R->G: Increase of activity."; /evidence="ECO:0000269|PubMed:11300774"; MUTAGEN 143; /note="R->A: Loss of activity."; /evidence="ECO:0000269|PubMed:11300774"; MUTAGEN 143; /note="R->K: Increase of activity."; /evidence="ECO:0000269|PubMed:11300774"; MUTAGEN 146; /note="R->N: No effect."; /evidence="ECO:0000269|PubMed:11300774"; MUTAGEN 146; /note="R->P: Increase of ATPase activity, decrease of ADPase activity."; /evidence="ECO:0000269|PubMed:11300774"; MUTAGEN 146; /note="R->T: Increase of activity."; /evidence="ECO:0000269|PubMed:11300774"; MUTAGEN 182; /note="E->D: Complete loss of activity."; /evidence="ECO:0000269|PubMed:11300774"; MUTAGEN 182; /note="E->Q: Complete loss of activity."; /evidence="ECO:0000269|PubMed:11300774"; MUTAGEN 187; /note="W->A: Complete loss of activity."; /evidence="ECO:0000269|PubMed:10231536"; MUTAGEN 191; /note="N->A: Loss of ATPase activity, increase of ADPase activity."; /evidence="ECO:0000269|PubMed:11300774"; MUTAGEN 219; /note="D->E: Increase of activity."; /evidence="ECO:0000269|PubMed:10231536"; MUTAGEN 224; /note="S->A: Complete loss of activity."; /evidence="ECO:0000269|PubMed:11300774"; MUTAGEN 226; /note="Q->A: Loss of activity."; /evidence="ECO:0000269|PubMed:11300774"; MUTAGEN 459; /note="W->A: Increase of activity, especially the ATP hydrolysis."; /evidence="ECO:0000269|PubMed:10231536
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:15966724}.
uniprot
proteins
protein_family
GDA1/CD39 NTPase family
uniprot
proteins
pubmed
10231536
uniprot
proteins
pubmed
11300774
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15966724
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
9675246
uniprot
proteins
pubmed
9676430
uniprot
proteins
sequence_length
529
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10231536}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..43; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 486..506; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins