Arpc5
entrez
360854
canonical
uniprot
Q4KLF8
canonical
ensembl
ENSRNOG00055017932
resolver
ensembl
ENSRNOG00060016816
resolver
ensembl
ENSRNOG00065026466
resolver
ensp
ENSRNOP00055024448
resolver
ensp
ENSRNOP00060023276
resolver
ensp
ENSRNOP00065037543
resolver
enst
ENSRNOT00055030393
resolver
enst
ENSRNOT00060028908
resolver
enst
ENSRNOT00065045771
resolver
genesymbol
Arpc5
resolver
uniprot_entry
ARPC5_RAT
resolver
amino_acid_sequence
MSKNTVSSARFRKVDVDEYDENKFVDEEDGGDGQAGPDEGEVDSCLRQGNMTAALQAALKNPPINTKSQAVKDRAGSIVLKVLISFKANDIEKAVQSLDKNGVDLLMKYIYKGFESPSDNSSAMLLQWHEKALAAGGVGSIVRVLTARKTV
uniprot
proteins
function
FUNCTION: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). {ECO:0000250|UniProtKB:O15511}.
uniprot
proteins
mass_dalton
16320
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated by RNF128 with 'Lys-63'-linked chains, leading to proteasomal degradation. {ECO:0000250|UniProtKB:O15511}.
uniprot
proteins
protein_family
ARPC5 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
151
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O15511}. Cell projection {ECO:0000250|UniProtKB:O15511}. Nucleus {ECO:0000250|UniProtKB:O15511}.
uniprot
proteins