JDP2
entrez
122953
canonical
uniprot
Q8WYK2
canonical
ensembl
ENSG00000140044
resolver
ensp
ENSP00000267569
resolver
ensp
ENSP00000399587
resolver
ensp
ENSP00000415558
resolver
ensp
ENSP00000498745
resolver
ensp
ENSP00000550034
resolver
genesymbol
JDP2
resolver
hgnc
HGNC:17546
resolver
uniprot
J3KN58
resolver
uniprot
O95430
resolver
uniprot
Q9UIE4
resolver
uniprot_entry
JDP2_HUMAN
resolver
uniprot_sec
J3KN58
resolver
uniprot_sec
O95430
resolver
uniprot_sec
Q9UIE4
resolver
amino_acid_sequence
MMPGQIPDPSVTTGSLPGLGPLTGLPSSALTVEELKYADIRNLGAMIAPLHFLEVKLGKRPQPVKSELDEEEERRKRRREKNKVAAARCRNKKKERTEFLQRESERLELMNAELKTQIEELKQERQQLILMLNRHRPTCIVRTDSVKTPESEGNPLLEQLEKK
uniprot
proteins
function
FUNCTION: Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin. {ECO:0000269|PubMed:12707301, ECO:0000269|PubMed:12903123, ECO:0000269|PubMed:16026868, ECO:0000269|PubMed:16518400}.
uniprot
proteins
mass_dalton
18704
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Thr-148 by MAPK8 in response to different stress conditions such as, UV irradiation, oxidatives stress and anisomycin treatments. {ECO:0000269|PubMed:18307971}.; PTM: Polyubiquitinated; probably by IRF2BP1. {ECO:0000269|PubMed:18671972}.
uniprot
proteins
protein_family
ATF subfamily
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
12707301
uniprot
proteins
pubmed
12903123
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16026868
uniprot
proteins
pubmed
16518400
uniprot
proteins
pubmed
18307971
uniprot
proteins
pubmed
18671972
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
163
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins