Nedd1
entrez
17997
canonical
uniprot
P33215
canonical
ensembl
ENSMUSG00000019988
resolver
ensp
ENSMUSP00000020163
resolver
genesymbol
Nedd1
resolver
genesymbol_syn
Nedd-1
resolver
uniprot
Q6NXV3
resolver
uniprot
Q8BN12
resolver
uniprot
Q8BN86
resolver
uniprot
Q8BQL9
resolver
uniprot
Q9CWK2
resolver
uniprot_entry
NEDD1_MOUSE
resolver
uniprot_sec
Q6NXV3
resolver
uniprot_sec
Q8BN12
resolver
uniprot_sec
Q8BN86
resolver
uniprot_sec
Q8BQL9
resolver
uniprot_sec
Q9CWK2
resolver
amino_acid_sequence
MQENLRFASSGDDVKIWDASFLTLVDKFNPHTSPHGISSICWSSNNNFLVTASSSGDKIVVSSCKCKPVPLLELAEGQKQTCVDLNSTSMYLASGGLNNTVNIWDLKSKRLHRSLKDHKCEVTCVAYNWNDCYIASGSLSGEIILHSVTTNTSSTPFGHGSKQPIRHIKYSLFRKSLLGSVSDNGVVTLWDVNSQSSYHTFDSTHKAPASGICFSPVNELLFVTIGLDKRIILYDTSSKKLVKTLVADTPLTAVDFMPDGATLAIGSSRGKIYQYDLRMLKSPVKTISAHKTSVQCIAFQYSTSLTKASLSKGSSNKATAVNKRSVPVSSSSGAAQNSGIVREAPSPSIATVLPQPVTTALGKGSGAAQDEAGLARSKSTDIFSKETDAGKSQDFSSFDDTGKNSLGDMFSPIRDDAVVSKGGDESIGKGDGLDFLPQLNSVFPLRKNAGASSSLVLHSSPLNVLMGSSGKEENESHEPSAESKRAYLGKQEPKDAMKQFTKLISSGAEPGILNTCPSSNQARNLEKFEKPEKDIEAQLIHEPSVNGSSTTVPKAASSVTAGVASSLSEKIVDTLGNSRPGAPLTSVQIRFIQNMIQETLDDFREACHRDIVNLQVEMIKQFHIQLNEMHSLLERYSVNEGLVAEIERLREENKRLRAHF
uniprot
proteins
function
FUNCTION: Required for mitosis progression. Promotes the nucleation of microtubules from the spindle (By similarity). May play an important role during the embryonic development and differentiation of the central nervous system (PubMed:1378265). {ECO:0000250|UniProtKB:Q8NHV4, ECO:0000269|PubMed:1378265}.
uniprot
proteins
mass_dalton
71292
uniprot
proteins
post_translational_modification
PTM: During mitosis, prior phosphorylation on Thr-550 by CDK1 promotes subsequent phosphorylation by PLK1 on Ser-397, Ser-426 and Ser-637. Phosphorylated NEDD1 can interact with gamma-tubulin for targeting the gamma-tubulin ring complex (gTuRC) to the centrosome, an important step for spindle formation. {ECO:0000250|UniProtKB:Q8NHV4}.
uniprot
proteins
pubmed
1378265
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
660
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q8NHV4}.
uniprot
proteins