CYP46A1
entrez
10858
canonical
uniprot
Q9Y6A2
canonical
ensembl
ENSG00000036530
resolver
ensp
ENSP00000261835
resolver
ensp
ENSP00000570152
resolver
genesymbol
CYP46A1
resolver
genesymbol_syn
CYP46
resolver
hgnc
HGNC:2641
resolver
uniprot
B4DHP8
resolver
uniprot
E7EQG9
resolver
uniprot
Q8N2B0
resolver
uniprot_entry
CP46A_HUMAN
resolver
uniprot_sec
B4DHP8
resolver
uniprot_sec
E7EQG9
resolver
uniprot_sec
Q8N2B0
resolver
amino_acid_sequence
MSPGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQLREVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRGWQPAPPPPPC
uniprot
proteins
ec_number
1.14.14.25
uniprot
proteins
function
FUNCTION: P450 monooxygenase that plays a major role in cholesterol homeostasis in the brain. Primarily catalyzes the hydroxylation (with S stereochemistry) at C-24 of cholesterol side chain, triggering cholesterol diffusion out of neurons and its further degradation (PubMed:10377398, PubMed:14640697, PubMed:18621681, PubMed:25017465). By promoting constant cholesterol elimination in neurons, may activate the mevalonate pathway and coordinate the synthesis of new cholesterol and nonsterol isoprenoids involved in synaptic activity and learning (By similarity). Further hydroxylates cholesterol derivatives and hormone steroids on both the ring and side chain of these molecules, converting them into active oxysterols involved in lipid signaling and biosynthesis (PubMed:12077124, PubMed:14640697, PubMed:28190002). Acts as an epoxidase converting cholesta-5,24-dien-3beta-ol/desmosterol into (24S),25-epoxycholesterol, an abundant lipid ligand of nuclear NR1H2 and NR1H3 receptors shown to promote neurogenesis in developing brain (PubMed:25017465). May also catalyze the oxidative metabolism of xenobiotics, such as clotrimazole (PubMed:20667828). {ECO:0000250|UniProtKB:Q9WVK8, ECO:0000269|PubMed:10377398, ECO:0000269|PubMed:12077124, ECO:0000269|PubMed:14640697, ECO:0000269|PubMed:18621681, ECO:0000269|PubMed:20667828, ECO:0000269|PubMed:25017465, ECO:0000269|PubMed:28190002}.
uniprot
proteins
mass_dalton
56821
uniprot
proteins
pathway_participation
PATHWAY: Steroid metabolism; cholesterol degradation. {ECO:0000305|PubMed:14640697}.; PATHWAY: Lipid metabolism; C21-steroid hormone metabolism. {ECO:0000305|PubMed:14640697}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
10377398
uniprot
proteins
pubmed
12077124
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14640697
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18621681
uniprot
proteins
pubmed
20667828
uniprot
proteins
pubmed
23288837
uniprot
proteins
pubmed
25017465
uniprot
proteins
pubmed
28190002
uniprot
proteins
sequence_length
500
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9WVK8}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9WVK8}. Microsome membrane {ECO:0000250|UniProtKB:Q9WVK8}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9WVK8}. Postsynapse {ECO:0000250|UniProtKB:Q9WVK8}. Presynapse {ECO:0000250|UniProtKB:Q9WVK8}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9WVK8}.
uniprot
proteins
transmembrane_region
TRANSMEM 3..23; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins