NOC4L
entrez
79050
canonical
uniprot
Q9BVI4
canonical
ensembl
ENSG00000184967
resolver
ensembl
ENSG00000288146
resolver
ensp
ENSP00000328854
resolver
ensp
ENSP00000500901
resolver
ensp
ENSP00000566567
resolver
ensp
ENSP00000566569
resolver
ensp
ENSP00000566570
resolver
ensp
ENSP00000632527
resolver
enst
ENST00000330579
resolver
enst
ENST00000672504
resolver
genesymbol
NOC4L
resolver
hgnc
HGNC:28461
resolver
uniprot
Q8N2S5
resolver
uniprot
Q96I14
resolver
uniprot_entry
NOC4L_HUMAN
resolver
uniprot_sec
Q8N2S5
resolver
uniprot_sec
Q96I14
resolver
amino_acid_sequence
MEREPGAAGVRRALGRRLEAVLASRSEANAVFDILAVLQSEDQEEIQEAVRTCSRLFGALLERGELFVGQLPSEEMVMTGSQGATRKYKVWMRHRYHSCCNRLGELLGHPSFQVKELALSALLKFVQLEGAHPLEKSKWEGNYLFPRELFKLVVGGLLSPEEDQSLLLSQFREYLDYDDTRYHTMQAAVDAVARVTGQHPEVPPAFWNNAFTLLSAVSLPRREPTVSSFYVKRAELWDTWKVAHLKEHRRVFQAMWLSFLKHKLPLSLYKKVLLIVHDAILPQLAQPTLMIDFLTRACDLGGALSLLALNGLFILIHKHNLEYPDFYRKLYGLLDPSVFHVKYRARFFHLADLFLSSSHLPAYLVAAFAKRLARLALTAPPEALLMVLPFICNLLRRHPACRVLVHRPHGPELDADPYDPGEEDPAQSRALESSLWELQALQRHYHPEVSKAASVINQALSMPEVSIAPLLELTAYEIFERDLKKKGPEPVPLEFIPAQGLLGRPGELCAQHFTLS
uniprot
proteins
function
FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit (PubMed:34516797). During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Required for the translation of mRNAs related to activation of regulatory and conventional T cells but is not essential for global translation in regulatory T cells (By similarity). Ensures correct nucleolar localization of small ribosomal subunit processome member EMG1 as part of a complex with NOP14 and UTP14A (PubMed:27798105). Blocks TLR4 endocytosis, causing inhibition of the TICAM1/TRIF signaling pathway (By similarity). This leads to reduced production of inflammatory cytokines which ameliorates local and systemic inflammation and influences insulin sensitivity (By similarity). Inhibits SIRT1-mediated deacetylation of TP53/p53 (PubMed:36030331). Required during early embryogenesis to ensure blastocyst formation (By similarity). {ECO:0000250|UniProtKB:Q8BHY2, ECO:0000269|PubMed:27798105, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:36030331}.
uniprot
proteins
mass_dalton
58468
uniprot
proteins
protein_family
CBF/MAK21 family
uniprot
proteins
pubmed
12429849
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
27798105
uniprot
proteins
pubmed
28012024
uniprot
proteins
pubmed
34516797
uniprot
proteins
pubmed
34675215
uniprot
proteins
pubmed
36030331
uniprot
proteins
sequence_length
516
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:28012024}; Multi-pass membrane protein {ECO:0000269|PubMed:12429849}. Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:36030331}. Nucleus, nucleoplasm {ECO:0000269|PubMed:36030331}. Cytoplasm {ECO:0000269|PubMed:36030331}. Cytoplasmic granule {ECO:0000269|PubMed:28012024}. Early endosome {ECO:0000250|UniProtKB:Q8BHY2}. Note=Localizes to the nucleolus under normal conditions but translocates to the nucleoplasm and cytoplasm under stress conditions. {ECO:0000269|PubMed:36030331}.
uniprot
proteins
transmembrane_region
TRANSMEM 297..317; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 347..367; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 375..395; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins