Rce1
entrez
19671
canonical
uniprot
P57791
canonical
ensembl
ENSMUSG00000024889
resolver
ensp
ENSMUSP00000025823
resolver
ensp
ENSMUSP00000153303
resolver
ensp
ENSMUSP00000153695
resolver
ensp
ENSMUSP00000157811
resolver
ensp
ENSMUSP00000241604
resolver
enst
ENSMUST00000025823
resolver
enst
ENSMUST00000224675
resolver
enst
ENSMUST00000224707
resolver
enst
ENSMUST00000237022
resolver
genesymbol
Rce1
resolver
genesymbol_syn
Face2
resolver
genesymbol_syn
Rce1a
resolver
uniprot
A0A286YD70
resolver
uniprot
A0A494B9U4
resolver
uniprot
A0ACM8Q296
resolver
uniprot
Q99KQ3
resolver
uniprot
Q9CSF8
resolver
uniprot
Q9EP68
resolver
uniprot_entry
A0A494B9U4_MOUSE
resolver
uniprot_entry
A0ACM8Q296_MOUSE
resolver
uniprot_entry
FACE2_MOUSE
resolver
uniprot_entry
Q99KQ3_MOUSE
resolver
uniprot_sec
A0A286YD70
resolver
uniprot_sec
Q9CSF8
resolver
uniprot_sec
Q9EP68
resolver
activity_regulation
ACTIVITY REGULATION: Deubiquitination by USP17L2/USP17 negatively regulates the proteolytic activity toward Ras GTPases. {ECO:0000250|UniProtKB:Q9Y256}.
uniprot
proteins
amino_acid_sequence
MAALGGDGLRLLSVSRPERQPESAALSGPGSGLCCWVSVFSCFSLACSYVGSLYVWKSELPRDHPAVIKRRSTSVLVVSSLSPLCVLLWRELTGIQPGTSLLTLMGFRLEGIFPAALLPLLLTMILFLGPLMQLSMDCPCDLTDGLKVVLAPRSWARCLTDMRWLRNQVIAPLTEELVFRACMLPMLAPCTGLGPAVFTCPLFFGVAHFHHIIEQLRFRQSSVGSIFVSAAFQFSYTAVFGAYTAFLFIRTGHLIGPVLCHSFCNYMGFPAVCAALEHPQKWPLLAGYALGVGLFLLLLQPLTDPKLYGSLPLCMLLERTGASETLLCS
uniprot
proteins
ec_number
3.4.26.1
uniprot
proteins
function
FUNCTION: Protease involved in the processing of a variety of prenylated proteins containing the C-terminal CAAX motif, where C is a cysteine modified with an isoprenoid lipid, A is an aliphatic amino acid and X is any C-terminal amino acid. Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins, leaving the prenylated cysteine as the new C-terminus. Is able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1. {ECO:0000250|UniProtKB:Q9Y256, ECO:0000305|PubMed:10085069}.
uniprot
proteins
mass_dalton
35867
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Undergoes 'Lys-48'- and 'Lys-63'-linked ubiquitination. 'Lys-48' ubiquitination induces its degradation. Deubiquitinated by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains (By similarity). {ECO:0000250|UniProtKB:Q9Y256}.
uniprot
proteins
protein_family
Peptidase U48 family
uniprot
proteins
pubmed
10085069
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
329
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Y256}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9Y256}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..56; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 75..95; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 112..132; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 193..213; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 226..246; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 254..274; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 282..302; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins