Hemk2
entrez
67768
canonical
uniprot
Q6SKR2
canonical
ensembl
ENSMUSG00000044442
resolver
ensp
ENSMUSP00000061835
resolver
ensp
ENSMUSP00000113229
resolver
genesymbol
Hemk2
resolver
genesymbol_syn
Kmt9
resolver
genesymbol_syn
N6amt1
resolver
genesymbol_syn
Pred28
resolver
uniprot
D3Z6J0
resolver
uniprot
E9PXT7
resolver
uniprot
Q4KMV5
resolver
uniprot
Q6PRU9
resolver
uniprot_entry
HEMK2_MOUSE
resolver
uniprot_sec
D3Z6J0
resolver
uniprot_sec
E9PXT7
resolver
uniprot_sec
Q4KMV5
resolver
uniprot_sec
Q6PRU9
resolver
amino_acid_sequence
MAAPSVPTPLYGHVGRGAFRDVYEPAEDTFLLLDALEAAAAELAGVEICLEVGAGSGVVSAFLASMIGPRALYMCTDINPEAAACTLETARCNRVHVQPVITDLVHGLLPRLKGKVDLLVFNPPYVVTPPEEVGSRGIEAAWAGGRNGREVMDRFFPLAPELLSPRGLFYLVTVKENNPEEIFKTMKTRGLQGTTALCRQAGQEALSVLRFSKS
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Methyltransferase that can methylate proteins and, to a lower extent, arsenic (PubMed:20606008, PubMed:26797129). Catalytic subunit of a heterodimer with TRMT112, which monomethylates 'Lys-12' of histone H4 (H4K12me1), a modification present at the promoters of numerous genes encoding cell cycle regulators (By similarity). Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif (PubMed:26797129). Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated (PubMed:20606008, PubMed:26797129). May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid (By similarity). It however only plays a limited role in arsenic metabolism compared with AS3MT (By similarity). {ECO:0000250|UniProtKB:Q9Y5N5, ECO:0000269|PubMed:20606008, ECO:0000269|PubMed:26797129}.
uniprot
proteins
mass_dalton
22984
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, leading to its degradation by the proteasome. {ECO:0000250|UniProtKB:Q9Y5N5}.
uniprot
proteins
protein_family
Eukaryotic/archaeal PrmC-related family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16684535
uniprot
proteins
pubmed
19116772
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20606008
uniprot
proteins
pubmed
26797129
uniprot
proteins
sequence_length
214
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16684535, ECO:0000269|PubMed:19116772}.
uniprot
proteins