TENM2
entrez
57451
canonical
uniprot
Q9NT68
canonical
ensembl
ENSG00000145934
resolver
ensp
ENSP00000427874
resolver
ensp
ENSP00000428964
resolver
ensp
ENSP00000429430
resolver
ensp
ENSP00000512239
resolver
ensp
ENSP00000512289
resolver
ensp
ENSP00000512290
resolver
enst
ENST00000519204
resolver
enst
ENST00000520394
resolver
enst
ENST00000695886
resolver
enst
ENST00000695961
resolver
genesymbol
TENM2
resolver
genesymbol_syn
KIAA1127
resolver
genesymbol_syn
ODZ2
resolver
genesymbol_syn
TNM2
resolver
hgnc
HGNC:29943
resolver
uniprot
A0A8Q3SI97
resolver
uniprot
A0A8Q3SIA3
resolver
uniprot
F8VNQ3
resolver
uniprot
G3V106
resolver
uniprot
Q9ULU2
resolver
uniprot_entry
A0A8Q3SI97_HUMAN
resolver
uniprot_entry
A0A8Q3SIA3_HUMAN
resolver
uniprot_entry
F8VNQ3_HUMAN
resolver
uniprot_entry
G3V106_HUMAN
resolver
uniprot_entry
TEN2_HUMAN
resolver
uniprot_sec
Q9ULU2
resolver
amino_acid_sequence
MDVKDRRHRSLTRGRCGKECRYTSSSLDSEDCRVPTQKSYSSSETLKAYDHDSRMHYGNRVTDLIHRESDEFPRQGTNFTLAELGICEPSPHRSGYCSDMGILHQGYSLSTGSDADSDTEGGMSPEHAIRLWGRGIKSRRSSGLSSRENSALTLTDSDNENKSDDENGRPIPPTSSPSLLPSAQLPSSHNPPPVSCQMPLLDSNTSHQIMDTNPDEEFSPNSYLLRACSGPQQASSSGPPNHHSQSTLRPPLPPPHNHTLSHHHSSANSLNRNSLTNRRSQIHAPAPAPNDLATTPESVQLQDSWVLNSNVPLETRHFLFKTSSGSTPLFSSSSPGYPLTSGTVYTPPPRLLPRNTFSRKAFKLKKPSKYCSWKCAALSAIAAALLLAILLAYFIAMHLLGLNWQLQPADGHTFNNGIRTGLPGNDDVATMPSGGKVPWSLKNSSIDSGEAEVGRRVTQEVPPGVFWRSQIHISQPQFLKFNISLGKDALFGVYIRRGLPPSHAQYDFMERLDGKEKWSVVESPRERRSIQTLVQNEAVFVQYLDVGLWHLAFYNDGKDKEMVSFNTVVLDSVQDCPRNCHGNGECVSGVCHCFPGFLGADCAKAACPVLCSGNGQYSKGTCQCYSGWKGAECDVPMNQCIDPSCGGHGSCIDGNCVCSAGYKGEHCEEVDCLDPTCSSHGVCVNGECLCSPGWGGLNCELARVQCPDQCSGHGTYLPDTGLCSCDPNWMGPDCSVEVCSVDCGTHGVCIGGACRCEEGWTGAACDQRVCHPRCIEHGTCKDGKCECREGWNGEHCTIGRQTAGTETDGCPDLCNGNGRCTLGQNSWQCVCQTGWRGPGCNVAMETSCADNKDNEGDGLVDCLDPDCCLQSACQNSLLCRGSRDPLDIIQQGQTDWPAVKSFYDRIKLLAGKDSTHIIPGENPFNSSLVSLIRGQVVTTDGTPLVGVNVSFVKYPKYGYTITRQDGTFDLIANGGASLTLHFERAPFMSQERTVWLPWNSFYAMDTLVMKTEENSIPSCDLSGFVRPDPIIISSPLSTFFSAAPGQNPIVPETQVLHEEIELPGSNVKLRYLSSRTAGYKSLLKITMTQSTVPLNLIRVHLMVAVEGHLFQKSFQASPNLAYTFIWDKTDAYGQRVYGLSDAVVSVGFEYETCPSLILWEKRTALLQGFELDPSNLGGWSLDKHHILNVKSGILHKGTGENQFLTQQPAIITSIMGNGRRRSISCPSCNGLAEGNKLLAPVALAVGIDGSLYVGDFNYIRRIFPSRNVTSILELRNKEFKHSNNPAHKYYLAVDPVSGSLYVSDTNSRRIYRVKSLSGTKDLAGNSEVVAGTGEQCLPFDEARCGDGGKAIDATLMSPRGIAVDKNGLMYFVDATMIRKVDQNGIISTLLGSNDLTAVRPLSCDSSMDVAQVRLEWPTDLAVNPMDNSLYVLENNVILRITENHQVSIIAGRPMHCQVPGIDYSLSKLAIHSALESASAIAISHTGVLYITETDEKKINRLRQVTTNGEICLLAGAASDCDCKNDVNCNCYSGDDAYATDAILNSPSSLAVAPDGTIYIADLGNIRIRAVSKNKPVLNAFNQYEAASPGEQELYVFNADGIHQYTVSLVTGEYLYNFTYSTDNDVTELIDNNGNSLKIRRDSSGMPRHLLMPDNQIITLTVGTNGGLKVVSTQNLELGLMTYDGNTGLLATKSDETGWTTFYDYDHEGRLTNVTRPTGVVTSLHREMEKSITIDIENSNRDDDVTVITNLSSVEASYTVVQDQVRNSYQLCNNGTLRVMYANGMGISFHSEPHVLAGTITPTIGRCNISLPMENGLNSIEWRLRKEQIKGKVTIFGRKLRVHGRNLLSIDYDRNIRTEKIYDDHRKFTLRIIYDQVGRPFLWLPSSGLAAVNVSYFFNGRLAGLQRGAMSERTDIDKQGRIVSRMFADGKVWSYSYLDKSMVLLLQSQRQYIFEYDSSDRLLAVTMPSVARHSMSTHTSIGYIRNIYNPPESNASVIFDYSDDGRILKTSFLGTGRQVFYKYGKLSKLSEIVYDSTAVTFGYDETTGVLKMVNLQSGGFSCTIRYRKIGPLVDKQIYRFSEEGMVNARFDYTYHDNSFRIASIKPVISETPLPVDLYRYDEISGKVEHFGKFGVIYYDINQIITTAVMTLSKHFDTHGRIKEVQYEMFRSLMYWMTVQYDSMGRVIKRELKLGPYANTTKYTYDYDGDGQLQSVAVNDRPTWRYSYDLNGNLHLLNPGNSVRLMPLRYDLRDRITRLGDVQYKIDDDGYLCQRGSDIFEYNSKGLLTRAYNKASGWSVQYRYDGVGRRASYKTNLGHHLQYFYSDLHNPTRITHVYNHSNSEITSLYYDLQGHLFAMESSSGEEYYVASDNTGTPLAVFSINGLMIKQLQYTAYGEIYYDSNPDFQMVIGFHGGLYDPLTKLVHFTQRDYDVLAGRWTSPDYTMWKNVGKEPAPFNLYMFKSNNPLSSELDLKNYVTDVKSWLVMFGFQLSNIIPGFPRAKMYFVPPPYELSESQASENGQLITGVQQTTERHNQAFMALEGQVITKKLHASIREKAGHWFATTTPIIGKGIMFAIKEGRVTTGVSSIASEDSRKVASVLNNAYYLDKMHYSIEGKDTHYFVKIGSADGDLVTLGTTIGRKVLESGVNVTVSQPTLLVNGRTRRFTNIEFQYSTLLLSIRYGLTPDTLDEEKARVLDQARQRALGTAWAKEQQKARDGREGSRLWTEGEKQQLLSTGRVQGYEGYYVLPVEQYPELADSSSNIQFLRQNEMGKR
uniprot
proteins
function
FUNCTION: Involved in neural development, regulating the establishment of proper connectivity within the nervous system (PubMed:21724987). Acts as a ligand of the ADGRL1 and ADGRL3 receptors that are expressed at the surface of adjacent cells (PubMed:21724987). Promotes the formation of filopodia and enlarged growth cone in neuronal cells (PubMed:21724987). Mediates axon guidance and homophilic and heterophilic cell-cell adhesion (PubMed:21724987). May function as a cellular signal transducer (PubMed:21724987). {ECO:0000269|PubMed:21724987}.; FUNCTION: [Isoform 2]: Acts as a ligand of the ADGRL1 receptor. Mediates axon guidance and heterophilic cell-cell adhesion. {ECO:0000269|PubMed:21724987}.; FUNCTION: [Ten-2 intracellular domain]: Induces gene transcription inhibition. {ECO:0000250|UniProtKB:Q9DER5}.
uniprot
proteins
mass_dalton
307787
uniprot
proteins
post_translational_modification
PTM: [Ten-2, soluble form]: Derives from the membrane form by proteolytic processing. {ECO:0000250|UniProtKB:Q9DER5}.; PTM: [Ten-2 intracellular domain]: Derives from the plasma membrane form by proteolytic cleavage and translocates to the nucleus. Homophilic binding of the C-terminal extracellular domain stimulates its proteolytic cleavage and release in the cytoplasmic. Is subjected to rapid degradation by the proteasome pathway (By similarity). {ECO:0000250|UniProtKB:Q9DER5}.
uniprot
proteins
protein_family
Tenascin family
uniprot
proteins
protein_family
Teneurin subfamily
uniprot
proteins
pubmed
10574461
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21724987
uniprot
proteins
sequence_length
2774
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21724987}; Single-pass membrane protein {ECO:0000255}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q9WTS5}; Single-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q9R1K2}; Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9DER5}. Golgi apparatus {ECO:0000250|UniProtKB:Q9DER5}. Synapse {ECO:0000250|UniProtKB:Q9R1K2}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q9R1K2}. Cell projection, filopodium {ECO:0000250|UniProtKB:Q9DER5}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q9DER5}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:21724987}. Note=Colocalizes with ADGRL1 across intercellular junctions. {ECO:0000269|PubMed:21724987}.; SUBCELLULAR LOCATION: [Ten-2 intracellular domain]: Nucleus, PML body {ECO:0000250|UniProtKB:Q9DER5}.
uniprot
proteins
transmembrane_region
TRANSMEM 380..400; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins