Sil1
entrez
291673
canonical
uniprot
Q6P6S4
canonical
genesymbol
Sil1
resolver
uniprot_entry
SIL1_RAT
resolver
amino_acid_sequence
MAPQHLPSTRMAPQGMLLGLLLASCLTFCLSCQNSNNFALTNPEKSTHEDSDTKETRREEELDAEVLEVLNPTQEWQALQPGQAVPAGSHVRMNLQTGVNEVKLQQEDKFQSNWKGFKRGRRLDINTNTYTSQDLKSALAKFKEGTEMENSKDELARQATVKQLFRPIEELKKEFDELNVVLETDMQIMVRLINKFNSSSSSLEEKVAALFDLEYYVHQMDNAQDLLSFGGLQVVINGLNSTEPLVKEYAAFVLGAAFSSNPKVQVEAIEGGALQKLLVILATEQPLPAKKKVLFALCSLLRHFPYAQQQFLKLGGLQVLRSLVQEKSAKVLAVRVVTLLYDLVTEKMFAEEEAELTQESSPEKLQQYRQVQLLPGLREQGWCEITAQLLALPEHDAREKVLQTLGALLATCRDRYRQDLELSRTLGSLQAEYQALASLELQEGEDDGYFRELLASIDSLVKELR
uniprot
proteins
function
FUNCTION: Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5. {ECO:0000250|UniProtKB:Q9H173}.
uniprot
proteins
mass_dalton
52350
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q9H173}.; PTM: Ubiquitinated by the CRL2(FEM1A) and CRL2(FEM1C) complexes, which recognize the -Lys-Xaa-Xaa-Arg C-degron at the C-terminus, leading to its degradation. {ECO:0000250|UniProtKB:Q9H173}.
uniprot
proteins
protein_family
SIL1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
465
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:Q9H173}.
uniprot
proteins