GPX2
entrez
2877
canonical
uniprot
P18283
canonical
ensembl
ENSG00000176153
resolver
ensp
ENSP00000374265
resolver
enst
ENST00000389614
resolver
genesymbol
GPX2
resolver
hgnc
HGNC:4554
resolver
uniprot
Q6PJ52
resolver
uniprot
Q8WWI7
resolver
uniprot
Q9NRP9
resolver
uniprot_entry
GPX2_HUMAN
resolver
uniprot_sec
Q6PJ52
resolver
uniprot_sec
Q8WWI7
resolver
uniprot_sec
Q9NRP9
resolver
amino_acid_sequence
MAFIAKSFYDLSAISLDGEKVDFNTFRGRAVLIENVASLUGTTTRDFTQLNELQCRFPRRLVVLGFPCNQFGHQENCQNEEILNSLKYVRPGGGYQPTFTLVQKCEVNGQNEHPVFAYLKDKLPYPYDDPFSLMTDPKLIIWSPVRRSDVAWNFEKFLIGPEGEPFRRYSRTFPTINIEPDIKRLLKVAI
uniprot
proteins
ec_number
1.11.1.12
uniprot
proteins
ec_number
1.11.1.9
uniprot
proteins
function
FUNCTION: Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis (PubMed:36608588, PubMed:8428933). Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides (PubMed:36608588, PubMed:8428933). Cannot reduce phosphatidycholine hydroperoxide (PubMed:8428933). {ECO:0000269|PubMed:36608588, ECO:0000269|PubMed:8428933}.
uniprot
proteins
mass_dalton
21954
uniprot
proteins
protein_family
Glutathione peroxidase family
uniprot
proteins
pubmed
10806356
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2388849
uniprot
proteins
pubmed
36608588
uniprot
proteins
pubmed
8428933
uniprot
proteins
sequence_length
190
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:8428933}.
uniprot
proteins