Crppa
entrez
493574
canonical
uniprot
Q5S6T3
canonical
ensembl
ENSRNOG00000006199
resolver
ensembl
ENSRNOG00055019678
resolver
ensembl
ENSRNOG00060005002
resolver
ensp
ENSRNOP00000008312
resolver
ensp
ENSRNOP00000073650
resolver
enst
ENSRNOT00000078548
resolver
genesymbol
Crppa
resolver
genesymbol_syn
Ispd
resolver
genesymbol_syn
Nip
resolver
uniprot
A0A0G2K627
resolver
uniprot
Q5S6T4
resolver
uniprot_entry
A0A0G2K627_RAT
resolver
uniprot_entry
ISPD_RAT
resolver
uniprot_sec
Q5S6T4
resolver
amino_acid_sequence
MESGPCSRPAEPRHCVSGRAGAGLAFPAFPLSAAGAEPGSRIGTVAAVLPAGGCGERMGVRTPKQFCRVLERPLISYTLQAMERVCWIKDIVVTVTGENMEAMRSIIQRYGHKRISLAEAGATRHRSIFNGLKALAEDQPGCELTRPEVVIIHDAVRPFVEEDILLRVVLAAKEHGAAGAIRPLVSTVVSPSADGHLDHSLDRAKHRASEMPQAFHFDVIYEAYQKCSDFDLEFGTECLQLALKYCHRKAKLVEGTPDLWKVTYKQDLCAAEAMIKEKISQEICVVVNTKDEESVGHLLEEVLRNELNCIKVTSTVLDRTSGDIENFIDQCYSFICVNVVSSESRETRKLLSILEESSLPLLYPVVVVLVHCFDFTVVPLAQKMENLVWIRELAKEAKGRNVLLSGVLLNHSQDEQKLQESLVQSAAIIAALVKERNSALVGQLLVA
uniprot
proteins
ec_number
2.7.7.40
uniprot
proteins
function
FUNCTION: Cytidylyltransferase required for protein O-linked mannosylation (By similarity). Catalyzes the formation of CDP-ribitol nucleotide sugar from D-ribitol 5-phosphate. CDP-ribitol is a substrate of FKTN during the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity (By similarity). Shows activity toward other pentose phosphate sugars and mediates formation of CDP-ribulose or CDP-ribose using CTP and ribulose-5-phosphate or ribose-5-phosphate, respectively (By similarity). Not involved in dolichol production (By similarity). {ECO:0000250|UniProtKB:A4D126}.
uniprot
proteins
mass_dalton
49192
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:A4D126}.
uniprot
proteins
protein_family
IspD subfamily
uniprot
proteins
protein_family
IspD/TarI cytidylyltransferase family
uniprot
proteins
sequence_length
447
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:A4D126}.
uniprot
proteins