SLC28A3
entrez
64078
canonical
uniprot
Q9HAS3
canonical
ensembl
ENSG00000197506
resolver
ensp
ENSP00000365413
resolver
genesymbol
SLC28A3
resolver
genesymbol_syn
CNT3
resolver
hgnc
HGNC:16484
resolver
uniprot
A8K9Y4
resolver
uniprot
B1AML0
resolver
uniprot
B2RA51
resolver
uniprot
B4E2S8
resolver
uniprot
F5GYE3
resolver
uniprot_entry
S28A3_HUMAN
resolver
uniprot_sec
A8K9Y4
resolver
uniprot_sec
B1AML0
resolver
uniprot_sec
B2RA51
resolver
uniprot_sec
B4E2S8
resolver
uniprot_sec
F5GYE3
resolver
amino_acid_sequence
MELRSTAAPRAEGYSNVGFQNEENFLENENTSGNNSIRSRAVQSREHTNTKQDEEQVTVEQDSPRNREHMEDDDEEMQQKGCLERRYDTVCGFCRKHKTTLRHIIWGILLAGYLVMVISACVLNFHRALPLFVITVAAIFFVVWDHLMAKYEHRIDEMLSPGRRLLNSHWFWLKWVIWSSLVLAVIFWLAFDTAKLGQQQLVSFGGLIMYIVLLFLFSKYPTRVYWRPVLWGIGLQFLLGLLILRTDPGFIAFDWLGRQVQTFLEYTDAGASFVFGEKYKDHFFAFKVLPIVVFFSTVMSMLYYLGLMQWIIRKVGWIMLVTTGSSPIESVVASGNIFVGQTESPLLVRPYLPYITKSELHAIMTAGFSTIAGSVLGAYISFGVPSSHLLTASVMSAPASLAAAKLFWPETEKPKITLKNAMKMESGDSGNLLEAATQGASSSISLVANIAVNLIAFLALLSFMNSALSWFGNMFDYPQLSFELICSYIFMPFSFMMGVEWQDSFMVARLIGYKTFFNEFVAYEHLSKWIHLRKEGGPKFVNGVQQYISIRSEIIATYALCGFANIGSLGIVIGGLTSMAPSRKRDIASGAVRALIAGTVACFMTACIAGILSSTPVDINCHHVLENAFNSTFPGNTTKVIACCQSLLSSTVAKGPGEVIPGGNHSLYSLKGCCTLLNPSTFNCNGISNTF
uniprot
proteins
function
FUNCTION: Sodium-dependent, pyrimidine- and purine-selective (PubMed:11032837, PubMed:15861042, PubMed:16446384, PubMed:17140564, PubMed:21998139). Involved in the homeostasis of endogenous nucleosides (PubMed:11032837, PubMed:15861042). Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine) (PubMed:11032837). Employs a 2:1 sodium/nucleoside ratio (PubMed:11032837). Transports uridine (PubMed:21795683). Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine (PubMed:11032837, PubMed:17140564). {ECO:0000269|PubMed:11032837, ECO:0000269|PubMed:15861042, ECO:0000269|PubMed:16446384, ECO:0000269|PubMed:17140564, ECO:0000269|PubMed:21795683, ECO:0000269|PubMed:21998139}.
uniprot
proteins
mass_dalton
76930
uniprot
proteins
mutagenesis
MUTAGEN 568; /note="S->P: Decreased uridine transport. Normal localization to the cell membrane."; /evidence="ECO:0000269|PubMed:21998139
uniprot
proteins
protein_family
Concentrative nucleoside transporter (CNT) (TC 2.A.41) family
uniprot
proteins
pubmed
11032837
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15738947
uniprot
proteins
pubmed
15861042
uniprot
proteins
pubmed
16446384
uniprot
proteins
pubmed
17140564
uniprot
proteins
pubmed
17993510
uniprot
proteins
pubmed
18827020
uniprot
proteins
pubmed
21795683
uniprot
proteins
pubmed
21998139
uniprot
proteins
pubmed
32776918
uniprot
proteins
sequence_length
691
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:21998139}; Multi-pass membrane protein {ECO:0000269|PubMed:32776918}.; SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18827020}; Multi-pass membrane protein {ECO:0000269|PubMed:32776918}.
uniprot
proteins
transmembrane_region
TRANSMEM 103..123; /note="Helical; Name=TM1"; /evidence="ECO:0000269|PubMed:32776918, ECO:0007744|PDB:6KSW"; TRANSMEM 129..149; /note="Helical; Name=TM2"; /evidence="ECO:0000269|PubMed:32776918, ECO:0007744|PDB:6KSW"; TRANSMEM 174..194; /note="Helical; Name=TM3"; /evidence="ECO:0000269|PubMed:32776918, ECO:0007744|PDB:6KSW"; TRANSMEM 198..219; /note="Helical; Name=TM4"; /evidence="ECO:0000269|PubMed:32776918, ECO:0007744|PDB:6KSW"; TRANSMEM 228..247; /note="Helical; Name=TM5"; /evidence="ECO:0000269|PubMed:32776918, ECO:0007744|PDB:6KSW"; TRANSMEM 285..305; /note="Helical; Name=TM6"; /evidence="ECO:0000269|PubMed:32776918, ECO:0007744|PDB:6KSW"; TRANSMEM 362..384; /note="Helical; Name=TM7"; /evidence="ECO:0000269|PubMed:32776918, ECO:0007744|PDB:6KSW"; TRANSMEM 387..408; /note="Helical; Name=TM8"; /evidence="ECO:0000269|PubMed:32776918, ECO:0007744|PDB:6KSW"; TRANSMEM 444..469; /note="Helical; Name=TM9"; /evidence="ECO:0000269|PubMed:32776918, ECO:0007744|PDB:6KSW"; TRANSMEM 567..577; /note="Helical; Name=TM10"; /evidence="ECO:0000269|PubMed:32776918, ECO:0007744|PDB:6KSW"; TRANSMEM 591..613; /note="Helical; Name=TM11"; /evidence="ECO:0000269|PubMed:32776918, ECO:0007744|PDB:6KSW
uniprot
proteins