AKAP13
entrez
11214
canonical
uniprot
Q12802
canonical
ensembl
ENSG00000170776
resolver
ensp
ENSP00000354718
resolver
ensp
ENSP00000378018
resolver
ensp
ENSP00000378026
resolver
enst
ENST00000394510
resolver
genesymbol
AKAP13
resolver
genesymbol_syn
BRX
resolver
genesymbol_syn
HT31
resolver
genesymbol_syn
LBC
resolver
hgnc
HGNC:371
resolver
uniprot
A8MYJ1
resolver
uniprot
B0AZU4
resolver
uniprot
Q14572
resolver
uniprot
Q59FP6
resolver
uniprot
Q86W90
resolver
uniprot
Q8WXQ6
resolver
uniprot
Q96JP6
resolver
uniprot
Q96P79
resolver
uniprot
Q9Y5T0
resolver
uniprot
Q9Y5T6
resolver
uniprot_entry
A8MYJ1_HUMAN
resolver
uniprot_entry
AKP13_HUMAN
resolver
uniprot_entry
B0AZU4_HUMAN
resolver
uniprot_sec
Q14572
resolver
uniprot_sec
Q59FP6
resolver
uniprot_sec
Q86W90
resolver
uniprot_sec
Q8WXQ6
resolver
uniprot_sec
Q96JP6
resolver
uniprot_sec
Q96P79
resolver
uniprot_sec
Q9Y5T0
resolver
uniprot_sec
Q9Y5T6
resolver
amino_acid_sequence
MKLNPQQAPLYGDCVVTVLLAEEDKAEDDVVFYLVFLGSTLRHCTSTRKVSSDTLETIAPGHDCCETVKVQLCASKEGLPVFVVAEEDFHFVQDEAYDAAQFLATSAGNQQALNFTRFLDQSGPPSGDVNSLDKKLVLAFRHLKLPTEWNVLGTDQSLHDAGPRETLMHFAVRLGLLRLTWFLLQKPGGRGALSIHNQEGATPVSLALERGYHKLHQLLTEENAGEPDSWSSLSYEIPYGDCSVRHHRELDIYTLTSESDSHHEHPFPGDGCTGPIFKLMNIQQQLMKTNLKQMDSLMPLMMTAQDPSSAPETDGQFLPCAPEPTDPQRLSSSEETESTQCCPGSPVAQTESPCDLSSIVEEENTDRSCRKKNKGVERKGEEVEPAPIVDSGTVSDQDSCLQSLPDCGVKGTEGLSSCGNRNEETGTKSSGMPTDQESLSSGDAVLQRDLVMEPGTAQYSSGGELGGISTTNVSTPDTAGEMEHGLMNPDATVWKNVLQGGESTKERFENSNIGTAGASDVHVTSKPVDKISVPNCAPAASSLDGNKPAESSLAFSNEETSTEKTAETETSRSREESADAPVDQNSVVIPAAAKDKISDGLEPYTLLAAGIGEAMSPSDLALLGLEEDVMPHQNSETNSSHAQSQKGKSSPICSTTGDDKLCADSACQQNTVTSSGDLVAKLCDNIVSESESTTARQPSSQDPPDASHCEDPQAHTVTSDPVRDTQERADFCPFKVVDNKGQRKDVKLDKPLTNMLEVVSHPHPVVPKMEKELVPDQAVISDSTFSLANSPGSESVTKDDALSFVPSQKEKGTATPELHTATDYRDGPDGNSNEPDTRPLEDRAVGLSTSSTAAELQHGMGNTSLTGLGGEHEGPAPPAIPEALNIKGNTDSSLQSVGKATLALDSVLTEEGKLLVVSESSAAQEQDKDKAVTCSSIKENALSSGTLQEEQRTPPPGQDTQQFHEKSISADCAKDKALQLSNSPGASSAFLKAETEHNKEVAPQVSLLTQGGAAQSLVPPGASLATESRQEALGAEHNSSALLPCLLPDGSDGSDALNCSQPSPLDVGVKNTQSQGKTSACEVSGDVTVDVTGVNALQGMAEPRRENISHNTQDILIPNVLLSQEKNAVLGLPVALQDKAVTDPQGVGTPEMIPLDWEKGKLEGADHSCTMGDAEEAQIDDEAHPVLLQPVAKELPTDMELSAHDDGAPAGVREVMRAPPSGRERSTPSLPCMVSAQDAPLPKGADLIEEAASRIVDAVIEQVKAAGALLTEGEACHMSLSSPELGPLTKGLESAFTEKVSTFPPGESLPMGSTPEEATGSLAGCFAGREEPEKIILPVQGPEPAAEMPDVKAEDEVDFRASSISEEVAVGSIAATLKMKQGPMTQAINRENWCTIEPCPDAASLLASKQSPECENFLDVGLGRECTSKQGVLKRESGSDSDLFHSPSDDMDSIIFPKPEEEHLACDITGSSSSTDDTASLDRHSSHGSDVSLSQILKPNRSRDRQSLDGFYSHGMGAEGRESESEPADPGDVEEEEMDSITEVPANCSVLRSSMRSLSPFRRHSWGPGKNAASDAEMNHRSSMRVLGDVVRRPPIHRRSFSLEGLTGGAGVGNKPSSSLEVSSANAEELRHPFSGEERVDSLVSLSEEDLESDQREHRMFDQQICHRSKQQGFNYCTSAISSPLTKSISLMTISHPGLDNSRPFHSTFHNTSANLTESITEENYNFLPHSPSKKDSEWKSGTKVSRTFSYIKNKMSSSKKSKEKEKEKDKIKEKEKDSKDKEKDKKTVNGHTFSSIPVVGPISCSQCMKPFTNKDAYTCANCSAFVHKGCRESLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKPSQPKERPRSAVLLVDETATTPIFANRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNKISKVNESTESLTDEGVGTDMNEGQLLGDFEIESKQLEAESWSRIIDSKFLKQQKKDVVKRQEVIYELMQTEFHHVRTLKIMSGVYSQGMMADLLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVNQFSGENAERLKKTYGKFCGQHNQSVNYFKDLYAKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLAQSLSLVKDVIGAVDSKVASYEKKVRLNEIYTKTDSKSIMRMKSGQMFAKEDLKRKKLVRDGSVFLKNAAGRLKEVQAVLLTDILVFLQEKDQKYIFASLDQKSTVISLKKLIVREVAHEEKGLFLISMGMTDPEMVEVHASSKEERNSWIQIIQDTINTLNRDEDEGIPSENEEEKKMLDTRARELKEQLHQKDQKILLLLEEKEMIFRDMAECSTPLPEDCSPTHSPRVLFRSNTEEALKGGPLMKSAINEVEILQGLVSGNLGGTLGPTVSSPIEQDVVGPVSLPRRAETFGGFDSHQMNASKGGEKEEGDDGQDLRRTESDSGLKKGGNANLVFMLKRNSEQVVQSVVHLYELLSALQGVVLQQDSYIEDQKLVLSERALTRSLSRPSSLIEQEKQRSLEKQRQDLANLQKQQAQYLEEKRRREREWEARERELREREALLAQREEEVQQGQQDLEKEREELQQKKGTYQYDLERLRAAQKQLEREQEQLRREAERLSQRQTERDLCQVSHPHTKLMRIPSFFPSPEEPPSPSAPSIAKSGSLDSELSVSPKRNSISRTHKDKGPFHILSSTSQTNKGPEGQSQAPASTSASTRLFGLTKPKEKKEKKKKNKTSRSQPGDGPASEVSAEGEEIFC
uniprot
proteins
function
FUNCTION: Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor (PubMed:11546812, PubMed:15229649, PubMed:23090968, PubMed:24993829, PubMed:25186459). May also activate other Rho family members (PubMed:11546812). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14 (PubMed:17537920, PubMed:21224381, PubMed:23716597). Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity (PubMed:23090968). Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G protein-coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (PubMed:16469733). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2 (PubMed:11579095, PubMed:9627117). Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (PubMed:21102438). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (By similarity). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (PubMed:11546812). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (By similarity). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:17537920, PubMed:23090968). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:23716597). Plays a role in osteogenesis (By similarity). {ECO:0000250|UniProtKB:E9Q394, ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:11579095, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:21224381, ECO:0000269|PubMed:23716597, ECO:0000269|PubMed:24993829, ECO:0000269|PubMed:25186459, ECO:0000269|PubMed:9627117, ECO:0000269|PubMed:9891067}.
uniprot
proteins
mass_dalton
307550
uniprot
proteins
mutagenesis
MUTAGEN 1251; /note="A->P: Abolishes interaction with PRKAR2A and leads to constitutive activation of RHOA; when associated with P-1260."; /evidence="ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:15229649"; MUTAGEN 1260; /note="I->P: Abolishes interaction with PRKAR2Aand leads to constitutive activation of RHOA; when associated with P-1251."; /evidence="ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:15229649"; MUTAGEN 1265; /note="A->P: Abolishes interaction with PRKAR2A."; /evidence="ECO:0000269|PubMed:1618839"; MUTAGEN 1565; /note="S->A: Abolishes interaction with YWHAB, leading to constitutive activation of RHOA and MAPK14."; /evidence="ECO:0000269|PubMed:15229649, ECO:0000269|PubMed:21224381"; MUTAGEN 2001; /note="E->A: Decreases guanyl nucleotide exchange activity toward RHOA."; /evidence="ECO:0000269|PubMed:24993829"; MUTAGEN 2136; /note="R->G: Decreases guanyl nucleotide exchange activity toward RHOA."; /evidence="ECO:0000269|PubMed:24993829"; MUTAGEN 2148; /note="Q->Y: Abolishes guanyl nucleotide exchange activity toward RHOA."; /evidence="ECO:0000269|PubMed:25186459"; MUTAGEN 2152; /note="K->Y: Abolishes guanyl nucleotide exchange activity toward RHOA."; /evidence="ECO:0000269|PubMed:25186459"; MUTAGEN 2153; /note="Y->F: Loss of guanyl nucleotide exchange activity toward RHOA."; /evidence="ECO:0000269|PubMed:11546812"; MUTAGEN 2189; /note="D->A: Reduces guanyl nucleotide exchange activity toward RHOA."; /evidence="ECO:0000269|PubMed:25186459"; MUTAGEN 2189; /note="D->Y: Abolishes guanyl nucleotide exchange activity toward RHOA."; /evidence="ECO:0000269|PubMed:25186459"; MUTAGEN 2289; /note="R->A: Decreases guanyl nucleotide exchange activity toward RHOA."; /evidence="ECO:0000269|PubMed:24993829"; MUTAGEN 2299; /note="F->A: Decreases guanyl nucleotide exchange activity toward RHOA."; /evidence="ECO:0000269|PubMed:24993829"; MUTAGEN 2324; /note="W->L: Impairs interaction with IKBKB."; /evidence="ECO:0000269|PubMed:23090968
uniprot
proteins
pubmed
11285229
uniprot
proteins
pubmed
11546812
uniprot
proteins
pubmed
11579095
uniprot
proteins
pubmed
11696353
uniprot
proteins
pubmed
15229649
uniprot
proteins
pubmed
15249197
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1618839
uniprot
proteins
pubmed
16469733
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17537920
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21102438
uniprot
proteins
pubmed
21224381
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23090968
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23716597
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24993829
uniprot
proteins
pubmed
25186459
uniprot
proteins
pubmed
8290273
uniprot
proteins
pubmed
9627117
uniprot
proteins
pubmed
9891067
uniprot
proteins
sequence_length
2813
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:11546812, ECO:0000269|PubMed:9891067}. Cytoplasm {ECO:0000269|PubMed:9627117}. Cytoplasm, cell cortex {ECO:0000269|PubMed:11546812}. Nucleus {ECO:0000269|PubMed:9627117}. Membrane {ECO:0000269|PubMed:11696353, ECO:0000269|PubMed:9891067}; Peripheral membrane protein {ECO:0000269|PubMed:11696353, ECO:0000305|PubMed:9891067}. Note=Colocalizes with the actin cytoskeleton at the cell cortex. {ECO:0000269|PubMed:11546812}.
uniprot
proteins