Rspo2
entrez
239405
canonical
uniprot
Q8BFU0
canonical
ensembl
ENSMUSG00000051920
resolver
ensp
ENSMUSP00000067325
resolver
ensp
ENSMUSP00000154600
resolver
ensp
ENSMUSP00000290824
resolver
ensp
ENSMUSP00000290831
resolver
enst
ENSMUST00000063492
resolver
enst
ENSMUST00000226810
resolver
genesymbol
Rspo2
resolver
uniprot
Q7TPX3
resolver
uniprot_entry
RSPO2_MOUSE
resolver
uniprot_sec
Q7TPX3
resolver
amino_acid_sequence
MRFCLFSFALIILNCMDYSQCQGNRWRRNKRASYVSNPICKGCLSCSKDNGCSRCQQKLFFFLRREGMRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFDECPDGFAPLDETMECVEGCEVGHWSEWGTCSRNNRTCGFKWGLETRTRQIVKKPAKDTIPCPTIAESRRCKMAMRHCPGGKRTPKAKEKRNKKKRRKLIERAQEQHSVFLATDRVNQ
uniprot
proteins
function
FUNCTION: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors (PubMed:21693646). During embryonic development, plays a crucial role in limb specification, amplifying the Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3, hence governing the number of limbs an embryo should form (By similarity). {ECO:0000250|UniProtKB:Q6UXX9, ECO:0000269|PubMed:21693646}.
uniprot
proteins
mass_dalton
28276
uniprot
proteins
protein_family
R-spondin family
uniprot
proteins
pubmed
15469841
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16543246
uniprot
proteins
pubmed
21693646
uniprot
proteins
sequence_length
243
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16543246}.
uniprot
proteins