MROH1
entrez
727957
canonical
uniprot
Q8NDA8
canonical
ensembl
ENSG00000179832
resolver
ensp
ENSP00000321737
resolver
ensp
ENSP00000388174
resolver
ensp
ENSP00000435565
resolver
ensp
ENSP00000436636
resolver
ensp
ENSP00000536181
resolver
ensp
ENSP00000536182
resolver
ensp
ENSP00000536183
resolver
ensp
ENSP00000536184
resolver
ensp
ENSP00000536186
resolver
ensp
ENSP00000536189
resolver
ensp
ENSP00000590130
resolver
ensp
ENSP00000632263
resolver
ensp
ENSP00000632268
resolver
ensp
ENSP00000647912
resolver
ensp
ENSP00000689599
resolver
enst
ENST00000534366
resolver
enst
ENST00000866122
resolver
enst
ENST00000866123
resolver
enst
ENST00000866130
resolver
enst
ENST00000962209
resolver
genesymbol
MROH1
resolver
genesymbol_syn
HEATR7A
resolver
genesymbol_syn
KIAA1833
resolver
hgnc
HGNC:26958
resolver
uniprot
B4DIR5
resolver
uniprot
C9JWM5
resolver
uniprot
D3DWL5
resolver
uniprot
E9PHY8
resolver
uniprot
Q0P612
resolver
uniprot
Q569G6
resolver
uniprot
Q6NVW4
resolver
uniprot
Q8N230
resolver
uniprot
Q8NAD1
resolver
uniprot
Q8ND95
resolver
uniprot
Q96JJ4
resolver
uniprot_entry
B4DIR5_HUMAN
resolver
uniprot_entry
E9PHY8_HUMAN
resolver
uniprot_entry
MROH1_HUMAN
resolver
uniprot_sec
C9JWM5
resolver
uniprot_sec
D3DWL5
resolver
uniprot_sec
Q0P612
resolver
uniprot_sec
Q569G6
resolver
uniprot_sec
Q6NVW4
resolver
uniprot_sec
Q8N230
resolver
uniprot_sec
Q8NAD1
resolver
uniprot_sec
Q8ND95
resolver
uniprot_sec
Q96JJ4
resolver
amino_acid_sequence
MTESSMKKLASTLLDAITDKDPLVQEQVCSALCSLGEARPVETLRACEEYLRQHDKLAHPYRAAVLRAMERVLSSRASELDKDTASTIILLASSEMTKTKDLVWDWQQAASGVLVAVGRQFISKVMEELLRRLHPGTLPHCAVLHTLASLSVANAFGVVPFLPSVLSSLLPVLGVAKQDTVRVAFCSALQRFSEGALEYLANLDRAPDPTVRKDAFATDIFSAYDVLFHQWLQSREAKLRLAVVEALGPMSHLLPSERLEEQLPKLLPGILALYKKHAETFYLSKSLGQILEAAVSVGSRTLETQLDALLAALHSQICVPVESSSPLVMSNQKEVLRCFTVLACSSPDRLLAFLLPRLDTSNERTRVGTLQVVRHVINSAAAQMEDKKPFILSSMRLPLLDTNSKVKRAVVQVISAMAHHGYLEQPGGEAMIEYIVQQCALPPEQEPEKPGPGSKDPKADSVRAISVRTLYLVSTTVDRMSHVLWPYLLQFLTPVRFTGALTPLCRSLVHLAQKRQEAGADAFLIQYDAHASLPSPYAVTGRLLVVSSSPYLGDGRGAAALRLLSVLHPNIHPLLGQHWETTVPLLLGYLDEHTEETLPQEEWEEKLLMFLRDTLAIISDNAWICQLSLELCRQLPCYDEAPQEKNFLYKCIGTTLGAASSKEVVRKHLQELLETARYQEEAEREGLACCFGICAISHLEDTLAQLEDFVRSEVFRKSIGILNIFKDRSENEVEKVKSALILCYGHVAARAPRELVLAKVESDILRNICQHFSTKVLGIKVETKDPALKLCLVQSVCMVSRAICSSTQAGSFHFTRKAELVAQMMEFIRAEPPDSLRTPIRKKAMLTCTYLVSVEPALDEQARADVIHGCLHSIMALLPEPKEEDGGCQKSLYLETLHALEDLLTSLLQRNMTPQGLQIMIEHLSPWIKSPRGHERARALGLSALLLRYFLEHLRVSALVPFHNLGLLIGLFSPRCADLWPATRQEAVDCVYSLLYLQLGYEGFSRDYRDDVAERLLSLKDGLVHPDPAILFHTCHSVGQIIAKRLPPDQLISLLLTMFEALGDPEKNCSRAATVMINCLLQERGGVLQEKVPEIVSVLRSKLQEAQGEHVLPAAQHSVYLLATQHCAAVVSSLLGSPLPLDSHTCMLWRALAVEPRLAAQVLGLLLEKMSRDVPFKESRAFLLGRTPDRVATLLPLSATCALFEVMSTPAAGPAVLELYPQLFVVLLLRVSCTVGVQLPRNLQAQERRGASPALATRNLEPCSSAVDTLRSMLLRSGSEDVVQRMDLEGGWELLRTSAGHEEGATRLARAMAEHAGPRLPLVLKTLACTHSSAYENQRVTTTAFLAELLNSNVANDLMLLDSLLESLAARQKDTCASVRRLVLRGLANLASGCPDKVRTHGPQLLTAMIGGLDDGDNPHSPVALEAMLGLARLVHLVESWDLRSGLLHVAIRIRPFFDSEKMEFRTASIRLFGHLNKVCHGDCEDVFLDQVVGGLAPLLLHLQDPQATVASACRFALRMCGPNLACEELSAAFQKHLQEGRALHFGEFLNTTCKHLMHHFPDLLGRLLTTCLFYFKSSWENVRAAAPLFTGFLVLHSEPRQQPQVDLDQLIAALQILLKDPAPEVRTRAAEALGRLVKLA
uniprot
proteins
function
FUNCTION: Lysosome fission factor (PubMed:38538795). Recruited to lysosomes by RAB7 (RAB7A or RAB7B) at scission sites and homooligomerizes to mediate the constriction and scission of lysosomal tubules (PubMed:38538795). May sever membranes by inserting amphipathic helices into one bilayer leaflet (PubMed:38538795). Lysosome fission is required to maintain their steady-state number, shape, size, composition and function, and to accomplish regeneration (PubMed:38538795). {ECO:0000269|PubMed:38538795}.
uniprot
proteins
mass_dalton
181249
uniprot
proteins
protein_family
MROH1 family
uniprot
proteins
pubmed
11347906
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
38538795
uniprot
proteins
sequence_length
1641
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:38538795}. Note=Recruited to the lysosome membrane by RAB7 (RAB7A or RAB7B). {ECO:0000269|PubMed:38538795}.
uniprot
proteins