Pde1c
entrez
18575
canonical
uniprot
Q64338
canonical
ensembl
ENSMUSG00000004347
resolver
ensp
ENSMUSP00000046601
resolver
ensp
ENSMUSP00000109966
resolver
ensp
ENSMUSP00000128364
resolver
ensp
ENSMUSP00000129185
resolver
ensp
ENSMUSP00000130139
resolver
ensp
ENSMUSP00000131350
resolver
ensp
ENSMUSP00000131892
resolver
ensp
ENSMUSP00000133170
resolver
ensp
ENSMUSP00000145508
resolver
ensp
ENSMUSP00000158960
resolver
ensp
ENSMUSP00000218804
resolver
ensp
ENSMUSP00000218807
resolver
enst
ENSMUST00000164037
resolver
enst
ENSMUST00000166890
resolver
enst
ENSMUST00000170774
resolver
enst
ENSMUST00000203372
resolver
enst
ENSMUST00000239143
resolver
genesymbol
Pde1c
resolver
uniprot
A0A0N4SWG4
resolver
uniprot
A0A5F8MPG4
resolver
uniprot
E9Q7V6
resolver
uniprot
F6T810
resolver
uniprot
F6ZK45
resolver
uniprot
Q3USZ6
resolver
uniprot
Q5D0E7
resolver
uniprot
Q62045
resolver
uniprot
Q8BSV6
resolver
uniprot
Q8CDV2
resolver
uniprot
Q9D5W0
resolver
uniprot_entry
A0A0N4SWG4_MOUSE
resolver
uniprot_entry
A0A5F8MPG4_MOUSE
resolver
uniprot_entry
E9Q7V6_MOUSE
resolver
uniprot_entry
F6T810_MOUSE
resolver
uniprot_entry
F6ZK45_MOUSE
resolver
uniprot_entry
PDE1C_MOUSE
resolver
uniprot_entry
Q3USZ6_MOUSE
resolver
uniprot_entry
Q5D0E7_MOUSE
resolver
uniprot_entry
Q8CDV2_MOUSE
resolver
uniprot_entry
Q9D5W0_MOUSE
resolver
uniprot_sec
Q62045
resolver
uniprot_sec
Q8BSV6
resolver
activity_regulation
ACTIVITY REGULATION: Type I PDE are activated by the binding of calmodulin in the presence of Ca(2+) (PubMed:8810348). Different splice variants may have different sensitivities to Ca(2+) (PubMed:8810348). {ECO:0000269|PubMed:8810348}.; ACTIVITY REGULATION: [Isoform 3]: Exhibits a higher sensitivity to Ca(2+) stimulation than isoforms 1 and 2 (PubMed:8810348). {ECO:0000269|PubMed:8810348}.
uniprot
proteins
amino_acid_sequence
MESPTKEIEEFESNSLKHLQPEQIEKIWLRLRGLRKYKKTSQRLRSLVKQLERGEASVVDLKKNLEYAATVLESVYIDETRRLLDTEDELSDIQSDAVPSEVRDWLASTFTRQMGMMLRRSDEKPRFKSIVHAVQAGIFVERMYRRTSNMVGLSYPPAVIDALKDVDTWSFDVFSLNEASGDHALKFIFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKNPYHNLMHAADVTQTVHYLLYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRLLQEDEEMNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEAIEKPKALSLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDREAELGLPFSPLCDRKSTMVAQSQVGFIDFIVEPTFTVLTDMTEKIVSPLIDESSQTGGTGQRRSSLNSINSSDAKRSGVKSSGSDGSAPINNSVIPVDYKSFKATWTEVVQINRERWRAKVPKEEKAKKEAEEKARLAAEEKQKEMEAKSQAEQGTTSKGEKKTSGEAKSQVNGTRKGDNPRGKNSKGEKAGEKQQNGDLKDGKNKADKKDHSNTGNESKKTDGTKKRSHGSPAPSTSSTSRITLPVIKPPLRHFKRPAYASSSYAPSVPKKTDDHPVRYKMLDQRIKMKKIQNISHHWNKK
uniprot
proteins
ec_number
3.1.4.17
uniprot
proteins
function
FUNCTION: Calmodulin-dependent cyclic nucleotide phosphodiesterase with a dual specificity for cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:8810348). Exhibits high affinity for both cAMP and cGMP (By similarity). Modulates the amplitude and duration of the cAMP signal in sensory cilia in response to odorant stimulation, hence contributing to the generation of action potentials. Regulates smooth muscle cell proliferation. Regulates the stability of growth factor receptors, including PDGFRB (Probable). In kidney juxtaglomerular granular cells, inhibits renin release by decreasing cAMP levels (PubMed:19741056). {ECO:0000250|UniProtKB:Q14123, ECO:0000269|PubMed:19741056, ECO:0000269|PubMed:8810348, ECO:0000305|PubMed:29860631}.
uniprot
proteins
mass_dalton
80290
uniprot
proteins
protein_family
Cyclic nucleotide phosphodiesterase family
uniprot
proteins
protein_family
PDE1 subfamily
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19741056
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29860631
uniprot
proteins
pubmed
8810348
uniprot
proteins
sequence_length
706
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:29860631}.
uniprot
proteins