Stat3
entrez
25125
canonical
uniprot
P52631
canonical
ensembl
ENSRNOG00000019742
resolver
ensembl
ENSRNOG00055032275
resolver
ensembl
ENSRNOG00060012887
resolver
ensembl
ENSRNOG00065029490
resolver
ensp
ENSRNOP00000026760
resolver
ensp
ENSRNOP00055045927
resolver
ensp
ENSRNOP00060017357
resolver
ensp
ENSRNOP00065041898
resolver
enst
ENSRNOT00000026760
resolver
enst
ENSRNOT00055055737
resolver
enst
ENSRNOT00060021941
resolver
enst
ENSRNOT00065050949
resolver
genesymbol
Stat3
resolver
uniprot_entry
STAT3_RAT
resolver
amino_acid_sequence
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVDLFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMDLTSECATSPM
uniprot
proteins
function
FUNCTION: Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA (By similarity). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): acetylation promotes its transcription activity and cell differentiation while deacetylation and oxidation of lysine residues by LOXL3 inhibits differentiation (By similarity). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (By similarity). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation. May play an apoptotic role by transactivating BIRC5 expression under LEP activation (By similarity). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (By similarity). Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion. Following JAK/STAT signaling activation and as part of a complex with NFATC3 and NFATC4, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (PubMed:19538478). Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity). {ECO:0000250|UniProtKB:P40763, ECO:0000250|UniProtKB:P42227, ECO:0000269|PubMed:19538478}.
uniprot
proteins
mass_dalton
88040
uniprot
proteins
post_translational_modification
PTM: Activated through tyrosine phosphorylation by BMX. Tyrosine phosphorylated in response to IL6, IL11, CNTF, LIF, KITLG/SCF, CSF1, EGF, PDGF, IFN-alpha and OSM. Activated KIT promotes phosphorylation on tyrosine residues and subsequent translocation to the nucleus. Tyrosine phosphorylated in response to constitutively activated FGFR1, FGFR2, FGFR3 and FGFR4. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding STAT3 homodimers and maximal transcriptional activity. ARL2BP may participate in keeping the phosphorylated state of STAT3 within the nucleus. Tyrosine phosphorylated upon stimulation with EGF. Upon LPS challenge, phosphorylated within the nucleus by IRAK1. Phosphorylated on Ser-727 by RPS6KA5 (By similarity). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates IL6/interleukin-6 signaling (By similarity). Phosphorylation at Tyr-705 by FER, isoform M2 of PKM (PKM2) or PTK6 leads to an increase of its transcriptional activity. Phosphorylation at Tyr-705 is increased in the presence of calcineurin (By similarity). Phosphorylation at Tyr-640 by TYK2 negatively regulates transcriptional activity (By similarity). {ECO:0000250|UniProtKB:P40763, ECO:0000250|UniProtKB:P42227}.; PTM: Acetylated on lysine residues by EP300/p300, promoting its activation (By similarity). Acetylation at Lys-49 and Lys-87 by EP300/p300 promotes its activation (By similarity). Acetylation at Lys-87 by EP300/p300 promotes its association with BRD2 and recruitment to chromatin (By similarity). Deacetylated at Lys-49 and Lys-87 by HDAC1 (By similarity). Acetylation at Lys-685 by EP300/p300 promotes its homodimerization and activation (By similarity). Deacetylated at Lys-685 by HDAC3 (By similarity). Acetylated on lysine residues by CREBBP (By similarity). Deacetylation by LOXL3 leads to disrupt STAT3 dimerization and inhibit STAT3 transcription activity (By similarity). Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated (By similarity). {ECO:0000250|UniProtKB:P40763}.; PTM: 'Lys-63'-linked polyubiquitination at Lys-615, Lys-626, Lys-631 and Lys-642 by RNF220 regulates STAT3 stability, phosphorylation, nuclear translocation, and transcriptional activity. {ECO:0000250|UniProtKB:P40763}.; PTM: Some lysine residues are oxidized to allysine by LOXL3, leading to disrupt STAT3 dimerization and inhibit STAT3 transcription activity. Oxidation of lysine residues to allysine on STAT3 preferentially takes place on lysine residues that are acetylated. {ECO:0000250|UniProtKB:P40763}.; PTM: Methylated at Lys-140. Demethylation at Lys-140 by Jmjd1c facilitates its dephosphorylation by Ptpn6. {ECO:0000250|UniProtKB:P42227}.
uniprot
proteins
protein_family
Transcription factor STAT family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19427337
uniprot
proteins
pubmed
19538478
uniprot
proteins
pubmed
8530402
uniprot
proteins
sequence_length
770
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19538478}. Nucleus {ECO:0000269|PubMed:19538478}. Note=Shuttles between the nucleus and the cytoplasm. Translocated into the nucleus upon tyrosine phosphorylation and dimerization, in response to signaling by activated FGFR1, FGFR2, FGFR3 or FGFR4. Constitutive nuclear presence is independent of tyrosine phosphorylation. Predominantly present in the cytoplasm without stimuli. Upon leukemia inhibitory factor (LIF) stimulation, accumulates in the nucleus. The complex composed of BART and ARL2 plays an important role in the nuclear translocation and retention of STAT3 (By similarity). Translocates to the nucleus in the presence of EDN1 (PubMed:19538478). {ECO:0000250|UniProtKB:P40763, ECO:0000269|PubMed:19538478}.
uniprot
proteins