Arhgap44
entrez
303222
canonical
uniprot
F1LQX4
canonical
ensembl
ENSRNOG00000003603
resolver
ensembl
ENSRNOG00055031138
resolver
ensembl
ENSRNOG00060025258
resolver
ensembl
ENSRNOG00065008210
resolver
ensp
ENSRNOP00000004829
resolver
ensp
ENSRNOP00000066638
resolver
ensp
ENSRNOP00000096546
resolver
ensp
ENSRNOP00000103825
resolver
enst
ENSRNOT00000071595
resolver
genesymbol
Arhgap44
resolver
genesymbol_syn
Rich2
resolver
uniprot
A0A8L2QXS1
resolver
uniprot
F1LST2
resolver
uniprot
M0RAT0
resolver
uniprot_entry
A0A8L2QXS1_RAT
resolver
uniprot_entry
RHG44_RAT
resolver
uniprot_sec
F1LST2
resolver
uniprot_sec
M0RAT0
resolver
amino_acid_sequence
MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGAEADKRSKKLPLTTLAQCLMEGSAILGDDTLLGKMLKLCGETEDELAQELIHFELRVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALREEMEEAANRVEICRDQLSADMYSFVAKEIDYANYFQTLIEVQAEYHRKSLTLLQAVLPQIKAQQEAWVEKPSFGKPLEEHLMISGREIAFPIEACVTMLLECGMQEEGLFRVAPSASKLKKLKAALDCCVVDVQEYSADPHAIAGALKSYLRELPEPLMTFELYDEWIQASNIQEQDKRLQALWNACEKLPKANHNNIRYLIKFLSKLSEYQDVNKMTPSNMAIVLGPNLLWPQSEGNITEMMTTVSLQIVGIIEPIIQHADWFFPGEIEFNITGSYGSPVHVNHNANYSSMPSPDMDPADRRQPEQARRPLSVATDNMMLEFYKKDGLRKIQSMGVRVMDTSWVARRGSSAGRKAACAPPSMQPPAPPSELAAPLPSPLPEQVPDSPATPAPALSPSGASLQPTPERPSVSKSKELSPGSGQKGSPGSIQGTTCPGTQLGPQPAASPSQLPADQSPHTLRKVSKKLAPIPPKVPFVQPGTVSDQPTGQPSPVSLSPTPPSTPSPYGLSYPPGYSMASGQLSPASAPPLASPSVFTSTLAKSRPTPKPRQRPTLPPPQPPSVSLSASSPQSTEHPMLDGMSPGESMSTDLVHFDVPSIHIELGSTLRLSPLEHARRHSVTDKRDSEEESESTAL
uniprot
proteins
function
FUNCTION: GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1 (PubMed:25498153). In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity (PubMed:25498153). Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation (PubMed:25498153). In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation (By similarity). {ECO:0000250|UniProtKB:Q5SSM3, ECO:0000269|PubMed:25498153}.
uniprot
proteins
mass_dalton
89115
uniprot
proteins
mutagenesis
MUTAGEN 291; /note="R->M: Reduces GAP activity. Decreases inhibition of filopodia formation."; /evidence="ECO:0000269|PubMed:25498153
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23739967
uniprot
proteins
pubmed
25498153
uniprot
proteins
sequence_length
814
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, dendritic spine {ECO:0000269|PubMed:23739967, ECO:0000269|PubMed:25498153}. Recycling endosome {ECO:0000250|UniProtKB:Q5SSM3}. Presynapse {ECO:0000269|PubMed:23739967}. Cell projection, dendrite {ECO:0000269|PubMed:25498153}. Note=In CA1 hippocampal synapses, detected at both presynaptic and postsynaptic sites (By similarity). Located in convoluted dendritic plasma membrane sections enriched in polymerized actin and myosin (patches) along dendrites where often emerge filopodia (PubMed:25498153). {ECO:0000250|UniProtKB:Q5SSM3, ECO:0000269|PubMed:25498153}.
uniprot
proteins