NEU2
entrez
4759
canonical
uniprot
Q9Y3R4
canonical
ensembl
ENSG00000115488
resolver
ensp
ENSP00000233840
resolver
ensp
ENSP00000521075
resolver
enst
ENST00000233840
resolver
enst
ENST00000851001
resolver
genesymbol
NEU2
resolver
hgnc
HGNC:7759
resolver
uniprot
Q3KNW4
resolver
uniprot
Q6NTB4
resolver
uniprot_entry
NEUR2_HUMAN
resolver
uniprot_sec
Q3KNW4
resolver
uniprot_sec
Q6NTB4
resolver
amino_acid_sequence
MASLPVLQKESVFQSGAHAYRIPALLYLPGQQSLLAFAEQRASKKDEHAELIVLRRGDYDAPTHQVQWQAQEVVAQARLDGHRSMNPCPLYDAQTGTLFLFFIAIPGQVTEQQQLQTRANVTRLCQVTSTDHGRTWSSPRDLTDAAIGPAYREWSTFAVGPGHCLQLHDRARSLVVPAYAYRKLHPIQRPIPSAFCFLSHDHGRTWARGHFVAQDTLECQVAEVETGEQRVVTLNARSHLRARVQAQSTNDGLDFQESQLVKKLVEPPPQGCQGSVISFPSPRSGPGSPAQWLLYTHPTHSWQRADLGAYLNPRPPAPEAWSEPVLLAKGSCAYSDLQSMGTGPDGSPLFGCLYEANDYEEIVFLMFTLKQAFPAEYLPQ
uniprot
proteins
ec_number
3.2.1.18
uniprot
proteins
function
FUNCTION: Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosaccharides (PubMed:14613940, PubMed:22228546). Recognizes sialyl linkage positions of the glycan moiety as well as the supramolecular organization of the sialoglycoconjugate. Displays preference for alpha-(2->3)-sialylated GD1a and GT1B gangliosides over alpha-(2->8)-sialylated GD1b, in both monomeric forms and micelles. Hydrolyzes monomeric GM1 ganglioside, but has no activity toward the miscellar form (PubMed:14613940). Has lower sialidase activity for glycoproteins such as fetuin and TF/transferrin that carry a mixture of alpha-(2->3) and alpha-(2->6)-sialyl linkages. Cleaves milk oligosaccharide alpha-(2->3)-sialyllactose, but is inactive toward alpha-(2->6)-sialyllactose isomer. Has no activity toward colominic acid, a homomer of alpha-(2->8)-linked Neu5Ac residues (PubMed:14613940). {ECO:0000269|PubMed:14613940, ECO:0000269|PubMed:22228546}.
uniprot
proteins
mass_dalton
42254
uniprot
proteins
mutagenesis
MUTAGEN 45; /note="K->A: Changed exo-alpha-sialidase activity depending on the substrate."; /evidence="ECO:0000269|PubMed:22228546"; MUTAGEN 46; /note="D->A: Loss of exo-alpha-sialidase activity."; /evidence="ECO:0000269|PubMed:22228546"; MUTAGEN 218; /note="E->A,Q: Loss of exo-alpha-sialidase activity."; /evidence="ECO:0000269|PubMed:22228546"; MUTAGEN 270; /note="Q->A: Increased exo-alpha-sialidase activity depending on the substrate."; /evidence="ECO:0000269|PubMed:22228546"; MUTAGEN 270; /note="Q->E: No effect on exo-alpha-sialidase activity."; /evidence="ECO:0000269|PubMed:22228546
uniprot
proteins
protein_family
Glycosyl hydrolase 33 family
uniprot
proteins
pubmed
10191093
uniprot
proteins
pubmed
10561456
uniprot
proteins
pubmed
14613940
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15501818
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17426694
uniprot
proteins
pubmed
22228546
uniprot
proteins
pubmed
24591206
uniprot
proteins
sequence_length
380
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10561456}.
uniprot
proteins