Slc22a3
entrez
29504
canonical
uniprot
O88446
canonical
ensembl
ENSRNOG00000022946
resolver
ensembl
ENSRNOG00055027821
resolver
ensembl
ENSRNOG00060009873
resolver
ensembl
ENSRNOG00065029272
resolver
ensp
ENSRNOP00000029748
resolver
ensp
ENSRNOP00055039629
resolver
ensp
ENSRNOP00060013024
resolver
ensp
ENSRNOP00065041553
resolver
enst
ENSRNOT00000037369
resolver
enst
ENSRNOT00055048168
resolver
enst
ENSRNOT00060016671
resolver
enst
ENSRNOT00065050567
resolver
genesymbol
Slc22a3
resolver
genesymbol_syn
Oct3
resolver
uniprot_entry
S22A3_RAT
resolver
amino_acid_sequence
MPTFDQALRKAGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGSQPDYYWCRGPRATALAERCAWSPEEEWNLTTPELHVPAERRGQGHCHRYLLEDTNTSSELSCDPLAAFPNRSAPLVPCSGDWRYVETHSTIVSQFDLVCGNAWMLDLTQAILNLGFLAGAFTLGYAADRYGRLIVYLISCFGVGITGVVVAFAPNFSVFVIFRFLQGVFGKGAWMTCFVIVTEIVGSKQRRIVGIVIQMFFTLGIIILPGIAYFTPSWQGIQLAISLPSFLFLLYYWVVPESPRWLITRKQGEKALQILRRVAKCNGKHLSSNYSEITVTDEEVSNPSCLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGLIGGNLYMDFFISGLVELPGALLILLTIERLGRRLPFAASNIVAGVSCLVTAFLPEGIPWLRTTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAIWLELPLIIFGILASVCGGLVMLLPETKGIALPETVEDVEKLGSSQLHQCGRKKKTQVSTSNV
uniprot
proteins
function
FUNCTION: Electrogenic voltage-dependent uniporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:12538837, PubMed:16581093, PubMed:23458604, PubMed:9830022). Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient (PubMed:9632645, PubMed:9830022). Functions as a Na(+)- and Cl(-)-independent, bidirectional uniporter (PubMed:9830022). Implicated in neuronal monoamine neurotransmitters cellular uptake such as dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine, serotonin and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the brain (PubMed:16581093, PubMed:19416912, PubMed:9830022). Transports dopaminergic neuromodulators cyclo(his-pro) and salsolinol with low efficiency (By similarity). May be involved in the uptake and disposition of cationic compounds by renal clearance from the blood flow (By similarity). May contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (PubMed:17616214). Mediates the transport of polyamine spermidine and putrescine (PubMed:12538837, PubMed:23458604). Mediates the bidirectional transport of polyamine agmatine (PubMed:12538837). Also transports guanidine (PubMed:9632645). Mediates the transport of choline (By similarity). May mediate intracellular transport of organic cations due to its localization on endomembranes, thereby contributing to amine metabolism and intracellular signaling (PubMed:27659446). {ECO:0000250|UniProtKB:O75751, ECO:0000269|PubMed:12538837, ECO:0000269|PubMed:16581093, ECO:0000269|PubMed:17616214, ECO:0000269|PubMed:19416912, ECO:0000269|PubMed:23458604, ECO:0000269|PubMed:27659446, ECO:0000269|PubMed:9632645, ECO:0000269|PubMed:9830022}.
uniprot
proteins
mass_dalton
61050
uniprot
proteins
protein_family
Major facilitator (TC 2.A.1) superfamily
uniprot
proteins
protein_family
Organic cation transporter (TC 2.A.1.19) family
uniprot
proteins
pubmed
12538837
uniprot
proteins
pubmed
15817714
uniprot
proteins
pubmed
16581093
uniprot
proteins
pubmed
17616214
uniprot
proteins
pubmed
18513366
uniprot
proteins
pubmed
19416912
uniprot
proteins
pubmed
23458604
uniprot
proteins
pubmed
27659446
uniprot
proteins
pubmed
9632645
uniprot
proteins
pubmed
9830022
uniprot
proteins
sequence_length
551
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27659446}; Multi-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000269|PubMed:15817714}; Multi-pass membrane protein {ECO:0000305}. Basolateral cell membrane {ECO:0000250|UniProtKB:O75751}; Multi-pass membrane protein {ECO:0000305}. Mitochondrion membrane {ECO:0000269|PubMed:27659446}. Endomembrane system {ECO:0000269|PubMed:27659446}. Nucleus membrane {ECO:0000305|PubMed:27659446}. Nucleus outer membrane {ECO:0000305|PubMed:27659446}. Note=Localized to neuronal and glial plasma membranes (PubMed:27659446). Localized to the luminal/apical membrane of ciliated and brush epithelial cells in the airway (PubMed:15817714). Located to neuronal and glial endomembranes, including mitochondrial and nuclear membranes (PubMed:27659446). {ECO:0000269|PubMed:15817714, ECO:0000269|PubMed:27659446}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..41; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 177..197; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 236..256; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 264..284; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 376..396; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 463..483; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 493..513; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins