68918
entrez
68918
canonical
uniprot
Q8K1L6
canonical
ensembl
ENSMUSG00000043687
resolver
ensp
ENSMUSP00000119467
resolver
enst
ENSMUST00000123927
resolver
uniprot
E9PUE0
resolver
uniprot_entry
CP074_MOUSE
resolver
uniprot_sec
E9PUE0
resolver
amino_acid_sequence
MGLKPSCLKGFKMCVSSSNNNHDEAPVLNDKHLSVPNIIITPPTPTGMGLSRDSNKQVWMDELGSYQDDGELEPEA
uniprot
proteins
function
FUNCTION: [Isoform 1]: Associates with and recruits the catalytic subunit of the calcineurin complex (PPP3CA/Calcineurin A) to the plasma membrane, where it functions as a dynamic scaffold and regulator of PPP3CA activity thereby modulating calcineurin signaling (By similarity). In brown adipocytes, regulates thermogenesis by binding to PPP3CA, promoting the dephosphorylation of the PKA regulatory subunit, PRKAR2B. This modulation of PRKAR2B phosphorylation enhances PKA activity, thereby stimulating heat thermogenesis (PubMed:40355556). {ECO:0000250|UniProtKB:Q96GX8, ECO:0000269|PubMed:40355556}.
uniprot
proteins
mass_dalton
8286
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="G->A: Abolishes localization to plasma membrane. Leads to cytosolic relocalization."; /evidence="ECO:0000269|PubMed:40355556
uniprot
proteins
post_translational_modification
PTM: N-myristoylation, in combination with reversible S-acylation promote the association of CLMB with membranes. {ECO:0000250|UniProtKB:Q96GX8}.; PTM: Phosphorylated. Phosphorylation and dephosphorylation of CLMB regulate its interaction with PPP3CA, controlling its recruitment to the plasma membrane and modulate calcineurin signaling. Phosphorylation at Thr-44 increases CLMB binding to PPP3CA. Dephosphorylated by PPP3CA requires two CLMB molecules per PPP3CA allowing one CLMB to bind PPP3CA via its PxIxIT and the other CLMB to undergo LxVP-dependent dephosphorylation. {ECO:0000250|UniProtKB:Q96GX8}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
40355556
uniprot
proteins
sequence_length
76
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:40355556}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytosol {ECO:0000269|PubMed:40355556}.
uniprot
proteins