Pdcd1lg2
entrez
58205
canonical
uniprot
Q9WUL5
canonical
ensembl
ENSMUSG00000016498
resolver
ensp
ENSMUSP00000108195
resolver
ensp
ENSMUSP00000158422
resolver
enst
ENSMUST00000112576
resolver
enst
ENSMUST00000235164
resolver
genesymbol
Pdcd1lg2
resolver
genesymbol_syn
B7dc
resolver
genesymbol_syn
Btdc
resolver
genesymbol_syn
Cd273
resolver
genesymbol_syn
Pdl2
resolver
uniprot
Q3U304
resolver
uniprot_entry
PD1L2_MOUSE
resolver
uniprot_entry
Q3U304_MOUSE
resolver
amino_acid_sequence
MLLLLPILNLSLQLHPVAALFTVTAPKEVYTVDVGSSVSLECDFDRRECTELEGIRASLQKVENDTSLQSERATLLEEQLPLGKALFHIPSVQVRDSGQYRCLVICGAAWDYKYLTVKVKASYMRIDTRILEVPGTGEVQLTCQARGYPLAEVSWQNVSVPANTSHIRTPEGLYQVTSVLRLKPQPSRNFSCMFWNAHMKELTSAIIDPLSRMEPKVPRTWPLHVFIPACTIALIFLAIVIIQRKRI
uniprot
proteins
function
FUNCTION: Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11224527, PubMed:11283156, PubMed:12719480, PubMed:18641123). Acts as a ligand for the inhibitory receptor PDCD1/PD-1, inhibiting T-cell proliferation by blocking cell cycle progression and cytokine production (PubMed:11224527, PubMed:11283156, PubMed:12719480, PubMed:18641123). {ECO:0000269|PubMed:11224527, ECO:0000269|PubMed:11283156, ECO:0000269|PubMed:12719480, ECO:0000269|PubMed:18641123}.
uniprot
proteins
mass_dalton
27820
uniprot
proteins
mutagenesis
MUTAGEN 33; /note="D->S: No effect on PDCD1 binding."; /evidence="ECO:0000269|PubMed:12719480"; MUTAGEN 39; /note="S->Y: No effect on PDCD1 binding."; /evidence="ECO:0000269|PubMed:12719480"; MUTAGEN 41; /note="E->S: No effect on PDCD1 binding."; /evidence="ECO:0000269|PubMed:12719480"; MUTAGEN 56; /note="R->S: Significantly reduces the binding to PDCD1."; /evidence="ECO:0000269|PubMed:12719480"; MUTAGEN 58; /note="S->Y: No effect on PDCD1 binding."; /evidence="ECO:0000269|PubMed:12719480"; MUTAGEN 65; /note="D->S: No effect on PDCD1 binding."; /evidence="ECO:0000269|PubMed:12719480"; MUTAGEN 67; /note="S->Y: Significantly reduces the binding to PDCD1."; /evidence="ECO:0000269|PubMed:12719480"; MUTAGEN 71; /note="E->S: Significantly reduces the binding to PDCD1."; /evidence="ECO:0000269|PubMed:12719480"; MUTAGEN 72; /note="R->S: No effect on PDCD1 binding."; /evidence="ECO:0000269|PubMed:12719480"; MUTAGEN 84; /note="K->S: No effect on PDCD1 binding."; /evidence="ECO:0000269|PubMed:12719480"; MUTAGEN 88; /note="H->A: No effect on PDCD1 binding."; /evidence="ECO:0000269|PubMed:12719480"; MUTAGEN 101; /note="R->S: Significantly reduces the binding to PDCD1."; /evidence="ECO:0000269|PubMed:12719480"; MUTAGEN 103; /note="L->A: No effect on PDCD1 binding."; /evidence="ECO:0000269|PubMed:12719480"; MUTAGEN 105; /note="I->A: Abolishes the binding to PDCD1."; /evidence="ECO:0000269|PubMed:12719480"; MUTAGEN 111; /note="D->S: Abolishes the binding to PDCD1. Costimulates proliferation and IFNG production of T-cells."; /evidence="ECO:0000269|PubMed:12719480"; MUTAGEN 113; /note="K->S: Abolishes the binding to PDCD1. Costimulates proliferation and IFNG production of T-cells."; /evidence="ECO:0000269|PubMed:12719480"; MUTAGEN 116; /note="T->Y: No effect on PDCD1 binding."; /evidence="ECO:0000269|PubMed:12719480
uniprot
proteins
protein_family
BTN/MOG family
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
11224527
uniprot
proteins
pubmed
11283156
uniprot
proteins
pubmed
12719480
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18641123
uniprot
proteins
sequence_length
247
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9BQ51}; Single-pass type I membrane protein {ECO:0000305|PubMed:18641123}.
uniprot
proteins
transmembrane_region
TRANSMEM 222..242; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins