Fer1l5
entrez
100534273
canonical
uniprot
P0DM40
canonical
ensembl
ENSMUSG00000037432
resolver
ensp
ENSMUSP00000142130
resolver
enst
ENSMUST00000179162
resolver
genesymbol
Fer1l5
resolver
uniprot
M1INE8
resolver
uniprot
M1J7P7
resolver
uniprot
M1JB08
resolver
uniprot
M1JB80
resolver
uniprot_entry
FR1L5_MOUSE
resolver
uniprot_entry
M1INE8_MOUSE
resolver
uniprot_entry
M1JB08_MOUSE
resolver
uniprot_entry
M1JB80_MOUSE
resolver
uniprot_sec
M1J7P7
resolver
amino_acid_sequence
MLRVVVESASINPPLSTTPKAFVTVYFRDMMKRTRVEEGHDPIWNETLIWHLWNQPLENDSFLKVILQDSVSKKKERFIGLATVPLKRLAQRPKEVMFVRDLILLNHSMKPTNCTVTLHVAQIYDQDTEMTGNEELLGSTVNEVTQKKLMVSGLPMHRALASKPQHFQVRVKVFEARQLLGNNIKPVVKVNIADQQHLTRIKMGNNPFFNEIFFQNFHEVPAKFFEENISIEVVDSAASRSKAEIGRFQTDIGFIYHSPGHTLLRKWLGLCQRNKTTSGVRGYLKVTICALGVGDQALVDQKLPYEQNTRVQIFKSKEVPVSLAYLQFFIYCAEDLHFGTHKSATPVLEVELIGDKLRTKPQNPSDNPIWNQILTFQIQLPCLSSYIKFRVMDCSKYKCQDEIGSASLCLSQISSTGEEIQGMYSGFLPCFGPSFLTLRGGKKPPFRTSEEGTCIMDAVQHGLAYRGRIFVEIVTKIKSQQDSVMKDLSQEVTQVEMQYYRQKYGLCVIFLSCTMMPKFKDLIQFEVSMGHYGNKTDPNYKPLVSTTQYSPVIYDGTTYHYVPWYNTKPVVAVTSNWEDVGFRMNCLNLLHITRDRLKTNLDILKSIRNPRDPALLQQWEKLLKELQEDCRRPLPCMTDQPRANSLDRNKWQLRSQLLQQLAQMAKEAKPVNMVGTAKEWLHRLNAVIPEPQESLPDVLIWLMSRQQRVAYARVPAHTVLFSPAGPLSSGKFCGKIQNILLQYPEGEGQDTFPASLRVCMWLGNVKYSKNLKLLQQGSMVVYAETYENQAKTRDDWGQQGLYHCPNFSDVMGRKALPKTDFKAPPGWHWKDDWVVEPQRRLLLDIDINKSQVLEEVYENQLRNATGAWVPAAIPNTDVNGQPVEALENVKCPQGWHFKKNWIVKLNHAVDSEGWEYGVGIPPSGLPQIWNSVEKTYHSCRRRRWVRVRFRNHKELGQERSQEQETLSFLQMQDLSEEGKEGWEYGTFDSRFHLDPQPTSRFRRRCWHRQLAPNKDRGVASIFLLEGSLAVEQKDQPRKEMEKTRSWQPWKDLRHTPEDPRIPTTPFIYYILNKPHYYQLFCYIYQARNLMYNQILTFQEPFIQVVFLNHSLCTQTLRSSAAPTWSQSIIFQHLLLFEDPKDTRENPPLVVLELWQHDSRGNKILWGRSMWPPVVWLGLQDWVFTPLRWHPLVRELGEEEGEILASCELILETQKLKELHPPILSIPCKDGIYLLPKNIQPTMKMMAIEIMAWGLRNMTKVRYPQLLLECGGESLKTEPISNFQENPNFPTSTFFFTVFMPLEETHAQPLVVKVVDNQEYGQQIVVGQANIDFLQPYFCDPWSLNYTTVKLPTLSVKKPDTFLDFVYKKFWFDSSKDEEVYEEEVDWWSKLFWATGDADKSLNYNHKSYHTLKVYDCELEAVLTFKGLQDFCQTFKLYQEKPKVDSPVVGEFKGLFRIYPFPEDPEAPKPPRQFSAWPEIEDFPQMCLVRVYLIRAINLQPQDYNGLCDPYVILKLGQTKLGSRDSYYPNTLDPIFGMMYELTCNIPLEKDLEIQLFDFDLITADDEIGSTVIDLENRLLSGFGARCGLSKSYCKSGPFKWRDQMTPSYLLYRYAKQKGLPPPVFDLEGDSLYYNGETFKLQSFESAPPTYKHLGPKKERLALYILNTQGLVPEHVETRTLHSNSQPGIDQGKIQMWVDIFPKMLGPPGPQVNISPRKPKRYQLRCIIWSTAEVDLVQETFSKEKMSDIYVKGWLFGLEEDTQKTDVHYHSLTGEATFNWRFIFTMDYLTTERACVQSQKDYIWSLDPTSTKFPARLMIQIWDNDFFSPDDFLGVLELDLSDMPLPAQNIKQCSLKMMETDSKWPFTPQKRISLFKKTNVTGWWPCQVLDGDKWRLSGKVKMTLEMLSEREALIRPAGRGQSEPNQFPMLHPPERNDSFLLWYQSPIKNFCYAVCKRYRSKIICLVVTLVIGFILLNFVYSAPSYFAMNWIKPQLRLSSPIKIVNLIGTVNTSNINSSILTMEGSTYHASHVFPEAPAP
uniprot
proteins
function
FUNCTION: Plays a crucial role in male fertility, primarily through its involvement in the acrosome reaction of spermatozoa. Required for the Ca(2+)-activated fusion of the acrosomal membrane with the plasma membrane during the acrosome reaction (PubMed:36696506). May play a role in skeletal muscle cell development by ensuring effective myoblast fusion and facilitating membrane repair (PubMed:21177873, PubMed:33182221). {ECO:0000269|PubMed:21177873, ECO:0000269|PubMed:33182221, ECO:0000269|PubMed:36696506}.
uniprot
proteins
mass_dalton
235837
uniprot
proteins
mutagenesis
MUTAGEN 206..208; /note="NPF->SPL: Reduces interaction with EHD2."; /evidence="ECO:0000269|PubMed:21177873"; MUTAGEN 206; /note="N->C: Reduces interaction with EHD2."; /evidence="ECO:0000269|PubMed:21177873
uniprot
proteins
protein_family
Ferlin family
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21177873
uniprot
proteins
pubmed
33182221
uniprot
proteins
pubmed
36696506
uniprot
proteins
sequence_length
2038
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21177873, ECO:0000269|PubMed:33182221}; Single-pass type IV membrane protein {ECO:0000305}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:33182221}; Single-pass type IV membrane protein {ECO:0000305}. Note=Colocalizes with EHD1 and EHD2 at the plasma membrane in myoblasts and myotubes. Localizes into foci at the plasma membrane.
uniprot
proteins
transmembrane_region
TRANSMEM 1961..1981; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins