Slc16a1
entrez
25027
canonical
uniprot
P53987
canonical
ensembl
ENSRNOG00000019996
resolver
ensembl
ENSRNOG00055019230
resolver
ensembl
ENSRNOG00060025806
resolver
ensembl
ENSRNOG00065032425
resolver
ensp
ENSRNOP00000027234
resolver
ensp
ENSRNOP00055026573
resolver
ensp
ENSRNOP00060037031
resolver
ensp
ENSRNOP00065045972
resolver
enst
ENSRNOT00000027234
resolver
enst
ENSRNOT00055032820
resolver
enst
ENSRNOT00060044679
resolver
enst
ENSRNOT00065055810
resolver
genesymbol
Slc16a1
resolver
genesymbol_syn
Mct1
resolver
uniprot_entry
MOT1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by stilbene disulfonates, such as di-isothiocyanostilbene disulfonate(DIDS), a cross-linking reagent that forms covalent linkages with lysine groups. {ECO:0000269|PubMed:19473976}.
uniprot
proteins
amino_acid_sequence
MPPAIGGPVGYTPPDGGWGWAVVVGAFISIGFSYAFPKSITVFFKEIEIIFSATTSEVSWISSIMLAVMYAGGPISSILVNKYGSRPVMIAGGCLSGCGLIAASFCNTVQELYFCIGVIGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQAFFGIFGWRGSFLILGGLLLNCCVAGSLMRPIGPQQGKVEKLKSKESLQEAGKSDANTDLIGGSPKGEKLSVFQTVNKFLDLSLFTHRGFLLYLSGNVVMFFGLFTPLVFLSNYGKSKHFSSEKSAFLLSILAFVDMVARPSMGLAANTRWIRPRVQYFFAASVVANGVCHLLAPLSTTYVGFCIYAGVFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVILIIAGLYLFIGMGINYRLVAKEQKAEEKKRDGKEDETSTDVDEKPKKTMKETQSPAPLQNSSGDPAEEESPV
uniprot
proteins
function
FUNCTION: Bidirectional proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH. The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate. MCT1 is a major lactate exporter (PubMed:10417314, PubMed:10564700, PubMed:11719518, PubMed:17127621, PubMed:19473976, PubMed:8526936, PubMed:9374487, PubMed:9639576). Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (By similarity). Facilitates the protonated monocarboxylate form of succinate export, that its transient protonation upon muscle cell acidification in exercising muscle and ischemic heart. Functions via alternate outward- and inward-open conformation states. Protonation and deprotonation of 302-Asp is essential for the conformational transition (By similarity). {ECO:0000250|UniProtKB:P53985, ECO:0000250|UniProtKB:P53986, ECO:0000269|PubMed:10417314, ECO:0000269|PubMed:10564700, ECO:0000269|PubMed:11719518, ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:19473976, ECO:0000269|PubMed:8526936, ECO:0000269|PubMed:9374487, ECO:0000269|PubMed:9639576}.
uniprot
proteins
mass_dalton
53238
uniprot
proteins
mutagenesis
MUTAGEN 38; /note="K->Q,R: No effect on expression at the cell membrane, but abolishes lactate transport across the cell membrane."; /evidence="ECO:0000269|PubMed:19473976"; MUTAGEN 45; /note="K->Q,R: No effect on expression at the cell membrane. No effect on lactate transport across the cell membrane."; /evidence="ECO:0000269|PubMed:19473976"; MUTAGEN 86; /note="R->E,Q: No effect on expression at the cell membrane. No effect on lactate transport across the cell membrane."; /evidence="ECO:0000269|PubMed:17127621"; MUTAGEN 196; /note="R->E,Q: No effect on expression at the cell membrane. No effect on lactate transport across the cell membrane."; /evidence="ECO:0000269|PubMed:17127621"; MUTAGEN 282; /note="K->Q,R: No effect on expression at the cell membrane. No effect on lactate transport across the cell membrane."; /evidence="ECO:0000269|PubMed:19473976"; MUTAGEN 284; /note="K->Q,R: No effect on expression at the cell membrane. No effect on lactate transport across the cell membrane."; /evidence="ECO:0000269|PubMed:19473976"; MUTAGEN 290; /note="K->Q,R: No effect on expression at the cell membrane. No effect on lactate transport across the cell membrane."; /evidence="ECO:0000269|PubMed:19473976"; MUTAGEN 302; /note="D->R: Abolishes expression at the cell membrane. Abolishes lactate transport across the cell membrane without affecting expression at the cell membrane; when associated with E-306."; /evidence="ECO:0000269|PubMed:17127621"; MUTAGEN 306; /note="R->E: Abolishes expression at the cell membrane. Abolishes lactate transport across the cell membrane without affecting expression at the cell membrane; when associated with R-302."; /evidence="ECO:0000269|PubMed:17127621"; MUTAGEN 306; /note="R->K: No effect on expression at the cell membrane, but abolishes lactate transport across the cell membrane."; /evidence="ECO:0000269|PubMed:17127621"; MUTAGEN 413; /note="K->Q,R: No effect on expression at the cell membrane. No effect on lactate transport across the cell membrane."; /evidence="ECO:0000269|PubMed:19473976
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Monocarboxylate porter (TC 2.A.1.13) family
uniprot
proteins
pubmed
10417314
uniprot
proteins
pubmed
10564700
uniprot
proteins
pubmed
11719518
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16396499
uniprot
proteins
pubmed
17127621
uniprot
proteins
pubmed
19473976
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7548134
uniprot
proteins
pubmed
8526936
uniprot
proteins
pubmed
9169423
uniprot
proteins
pubmed
9374487
uniprot
proteins
pubmed
9639576
uniprot
proteins
sequence_length
494
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11719518, ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:19473976, ECO:0000269|PubMed:8526936, ECO:0000269|PubMed:9169423}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P53985}. Basolateral cell membrane {ECO:0000269|PubMed:10564700}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P53985}. Apical cell membrane {ECO:0000250|UniProtKB:P53985}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P53985}. Note=Expression at the cell surface requires the ancillary proteins BSG and EMB. {ECO:0000250|UniProtKB:P53985}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..44; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P53985"; TRANSMEM 56..80; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P53985"; TRANSMEM 85..105; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P53985"; TRANSMEM 110..132; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P53985"; TRANSMEM 147..169; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P53985"; TRANSMEM 175..194; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P53985"; TRANSMEM 255..281; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P53985"; TRANSMEM 289..310; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P53985"; TRANSMEM 322..342; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:P53985"; TRANSMEM 347..368; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:P53985"; TRANSMEM 383..403; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:P53985"; TRANSMEM 415..436; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:P53985
uniprot
proteins