HTR1D
entrez
3352
canonical
uniprot
P28221
canonical
ensembl
ENSG00000179546
resolver
ensp
ENSP00000363748
resolver
ensp
ENSP00000588634
resolver
ensp
ENSP00000588635
resolver
ensp
ENSP00000588636
resolver
ensp
ENSP00000588637
resolver
ensp
ENSP00000588638
resolver
ensp
ENSP00000588639
resolver
ensp
ENSP00000588640
resolver
ensp
ENSP00000588641
resolver
ensp
ENSP00000588642
resolver
ensp
ENSP00000588643
resolver
ensp
ENSP00000588644
resolver
ensp
ENSP00000588645
resolver
enst
ENST00000374619
resolver
enst
ENST00000918575
resolver
enst
ENST00000918576
resolver
enst
ENST00000918577
resolver
enst
ENST00000918578
resolver
enst
ENST00000918579
resolver
enst
ENST00000918580
resolver
enst
ENST00000918581
resolver
enst
ENST00000918582
resolver
enst
ENST00000918583
resolver
enst
ENST00000918584
resolver
enst
ENST00000918585
resolver
enst
ENST00000918586
resolver
genesymbol
HTR1D
resolver
genesymbol_syn
HTR1DA
resolver
genesymbol_syn
HTRL
resolver
hgnc
HGNC:5289
resolver
uniprot_entry
5HT1D_HUMAN
resolver
amino_acid_sequence
MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVLTTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDITCCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAKAQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFTTAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKATKILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFNEEFRQAFQKIVPFRKAS
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:10452531, PubMed:1565658, PubMed:1652050, PubMed:33762731). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances (PubMed:10452531, PubMed:1565658, PubMed:1652050, PubMed:33762731). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:10452531, PubMed:1565658, PubMed:1652050, PubMed:33762731). HTR1D is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (PubMed:33762731). Regulates the release of 5-hydroxytryptamine in the brain, and thereby affects neural activity (PubMed:18476671, PubMed:20945968). May also play a role in regulating the release of other neurotransmitters (PubMed:18476671, PubMed:20945968). May play a role in vasoconstriction (PubMed:18476671, PubMed:20945968). {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1565658, ECO:0000269|PubMed:1652050, ECO:0000269|PubMed:33762731, ECO:0000303|PubMed:18476671, ECO:0000303|PubMed:20945968}.
uniprot
proteins
mass_dalton
41907
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10391209
uniprot
proteins
pubmed
10452531
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1565658
uniprot
proteins
pubmed
1652050
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
1828434
uniprot
proteins
pubmed
18476671
uniprot
proteins
pubmed
20945968
uniprot
proteins
pubmed
33762731
uniprot
proteins
sequence_length
377
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1565658, ECO:0000269|PubMed:1652050}; Multi-pass membrane protein {ECO:0000269|PubMed:10452531, ECO:0000269|PubMed:1565658, ECO:0000269|PubMed:1652050}.
uniprot
proteins
transmembrane_region
TRANSMEM 39..64; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:33762731, ECO:0007744|PDB:7E32"; TRANSMEM 76..97; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:33762731, ECO:0007744|PDB:7E32"; TRANSMEM 110..134; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:33762731, ECO:0007744|PDB:7E32"; TRANSMEM 155..176; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:33762731, ECO:0007744|PDB:7E32"; TRANSMEM 195..218; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:33762731, ECO:0007744|PDB:7E32"; TRANSMEM 301..326; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:33762731, ECO:0007744|PDB:7E32"; TRANSMEM 336..359; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:33762731, ECO:0007744|PDB:7E32
uniprot
proteins