HSD17B8
entrez
7923
canonical
uniprot
Q92506
canonical
ensembl
ENSG00000112474
resolver
ensembl
ENSG00000204228
resolver
ensembl
ENSG00000225312
resolver
ensembl
ENSG00000228357
resolver
ensembl
ENSG00000228712
resolver
ensembl
ENSG00000232357
resolver
ensp
ENSP00000230236
resolver
ensp
ENSP00000363794
resolver
ensp
ENSP00000387753
resolver
ensp
ENSP00000403538
resolver
ensp
ENSP00000406488
resolver
ensp
ENSP00000413950
resolver
enst
ENST00000230236
resolver
enst
ENST00000374662
resolver
enst
ENST00000414463
resolver
enst
ENST00000422433
resolver
enst
ENST00000427295
resolver
enst
ENST00000454191
resolver
genesymbol
HSD17B8
resolver
genesymbol_syn
FABGL
resolver
genesymbol_syn
HKE6
resolver
genesymbol_syn
RING2
resolver
genesymbol_syn
SDR30C1
resolver
hgnc
HGNC:3554
resolver
uniprot
A6NLX7
resolver
uniprot
Q5STP7
resolver
uniprot
Q9UIQ1
resolver
uniprot_entry
DHB8_HUMAN
resolver
uniprot_sec
A6NLX7
resolver
uniprot_sec
Q5STP7
resolver
uniprot_sec
Q9UIQ1
resolver
amino_acid_sequence
MASQLQNRLRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPGSKEGPPRGNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVNLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAARELGRHGIRCNSVLPGFIATPMTQKVPQKVVDKITEMIPMGHLGDPEDVADVVAFLASEDSGYITGTSVEVTGGLFM
uniprot
proteins
ec_number
1.1.1.239
uniprot
proteins
ec_number
1.1.1.62
uniprot
proteins
ec_number
1.1.1.n12
uniprot
proteins
function
FUNCTION: Required for the solubility and assembly of the heterotetramer 3-ketoacyl-[acyl carrier protein] (ACP) reductase functional complex (KAR or KAR1) that forms part of the mitochondrial fatty acid synthase (mtFAS). Alpha-subunit of the KAR complex that acts as a scaffold protein required for the stability of carbonyl reductase type-4 (CBR4, beta-subunit of the KAR complex) and for its 3-ketoacyl-ACP reductase activity, thereby participating in mitochondrial fatty acid biosynthesis. Catalyzes the NAD-dependent conversion of (3R)-3-hydroxyacyl-CoA into 3-ketoacyl-CoA (3-oxoacyl-CoA) with no chain length preference; this enzymatic activity is not needed for the KAR function (PubMed:19571038, PubMed:25203508, PubMed:30508570). Prefers (3R)-3-hydroxyacyl-CoA over (3S)-3-hydroxyacyl-CoA and displays enzymatic activity only in the presence of NAD(+) (PubMed:19571038). Cooperates with enoyl-CoA hydratase 1 in mitochondria, together they constitute an alternative route to the auxiliary enzyme pathways for the breakdown of Z-PUFA (cis polyunsaturated fatty acid) enoyl-esters (Probable) (PubMed:30508570). NAD-dependent 17-beta-hydroxysteroid dehydrogenase with highest activity towards estradiol (17beta-estradiol or E2). Has very low activity towards testosterone and dihydrotestosterone (17beta-hydroxy-5alpha-androstan-3-one). Primarily an oxidative enzyme, it can switch to a reductive mode determined in the appropriate physiologic milieu and catalyze the reduction of estrone (E1) to form biologically active 17beta-estradiol (PubMed:17978863). {ECO:0000269|PubMed:17978863, ECO:0000269|PubMed:19571038, ECO:0000269|PubMed:25203508, ECO:0000303|PubMed:30508570, ECO:0000305|PubMed:25203508}.
uniprot
proteins
mass_dalton
26974
uniprot
proteins
mutagenesis
MUTAGEN 42; /note="D->A: Reduced NADH-dependent reductase activity with acetoacetyl-CoA. Reduced NADH-dependent reductase activity with 9,10-phenanthrene quinone. Increases NADPH-dependent reductase activities. No effect on the ability to restore growth of an OAR1-deficient yeast mutant."; /evidence="ECO:0000269|PubMed:25203508"; MUTAGEN 148; /note="R->E: No effect on the ability to restore growth of an OAR1-deficient yeast mutant."; /evidence="ECO:0000269|PubMed:25203508"; MUTAGEN 169; /note="Y->A: Strongly reduced NADH-dependent reductase activity with acetoacetyl-CoA. Strongly reduced NADH-dependent reductase activity with 9,10-phenanthrene quinone. Decreases NADPH-dependent reductase activity with acetoacetyl-CoA, but increases NADPH-dependent reductase activity with 9,10-phenanthrene quinone. No effect on the ability to restore growth of an OAR1-deficient yeast mutant."; /evidence="ECO:0000269|PubMed:25203508"; MUTAGEN 173; /note="K->A: Abolishes NADH-dependent reductase activity with acetoacetyl-CoA. Strongly reduced NADH-dependent reductase activity with 9,10-phenanthrene quinone. Slightly decreases NADPH-dependent reductase activity with acetoacetyl-CoA, but increases NADPH-dependent reductase activity with 9,10-phenanthrene quinone. No effect on the ability to restore growth of an OAR1-deficient yeast mutant."; /evidence="ECO:0000269|PubMed:25203508"; MUTAGEN 189; /note="R->E: No effect on the ability to restore growth of an OAR1-deficient yeast mutant."; /evidence="ECO:0000269|PubMed:25203508
uniprot
proteins
pathway_participation
PATHWAY: Steroid biosynthesis; estrogen biosynthesis. {ECO:0000269|PubMed:17978863}.; PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000269|PubMed:25203508}.; PATHWAY: Lipid metabolism; mitochondrial fatty acid beta-oxidation. {ECO:0000305|PubMed:25203508}.
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17978863
uniprot
proteins
pubmed
18852215
uniprot
proteins
pubmed
19571038
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25203508
uniprot
proteins
pubmed
30508570
uniprot
proteins
pubmed
8812499
uniprot
proteins
sequence_length
261
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:19571038}.
uniprot
proteins