Rab2b
entrez
76338
canonical
uniprot
P59279
canonical
ensembl
ENSMUSG00000022159
resolver
ensp
ENSMUSP00000022765
resolver
ensp
ENSMUSP00000131145
resolver
enst
ENSMUST00000022765
resolver
enst
ENSMUST00000167116
resolver
genesymbol
Rab2b
resolver
genesymbol_syn
Rab2B
resolver
uniprot
Q0PD64
resolver
uniprot
Q3TV67
resolver
uniprot_entry
Q0PD64_MOUSE
resolver
uniprot_entry
RAB2B_MOUSE
resolver
uniprot_sec
Q3TV67
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors (GDIs) which inhibit the dissociation of the nucleotide from the GTPase. {ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MTYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMVNIDGKQIKLQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRETFNHLTSWLEDARQHSSSNMVIMLIGNKSDLESRRDVKREEGEAFAREHGLIFMETSAKTACNVEEAYINTAKEIYRKIQQGLFDVHNEANGIKIGPQQSITSSVGPCSPQQNVSDIGPDSGCC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states (PubMed:28930687). In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (PubMed:28930687). Regulates the compacted morphology of the Golgi (By similarity). Promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis (PubMed:28930687). Together with RAB2A redundantly required for efficient autophagic flux (PubMed:28063257). {ECO:0000250|UniProtKB:Q8WUD1, ECO:0000269|PubMed:28063257, ECO:0000269|PubMed:28930687}.
uniprot
proteins
mass_dalton
24198
uniprot
proteins
mutagenesis
MUTAGEN 20; /note="S->N: Constitutively inactive. Loss of Golgi apparatus location. Loss of interaction with GARIN1B."; /evidence="ECO:0000269|PubMed:28930687, ECO:0000269|PubMed:34714330"; MUTAGEN 65; /note="Q->L: Constitutively active. Interacts with GARIN1B."; /evidence="ECO:0000269|PubMed:28930687, ECO:0000269|PubMed:34714330
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28063257
uniprot
proteins
pubmed
28930687
uniprot
proteins
pubmed
34714330
uniprot
proteins
sequence_length
216
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:28930687, ECO:0000269|PubMed:34714330}; Lipid-anchor {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:34714330}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:28063257}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Localized in the Golgi apparatus in the round spermatids and in the acrosome in the elongating spermatid. {ECO:0000269|PubMed:34714330}.
uniprot
proteins