Atic
entrez
81643
canonical
uniprot
O35567
canonical
ensembl
ENSRNOG00000015511
resolver
ensembl
ENSRNOG00055010094
resolver
ensembl
ENSRNOG00060023906
resolver
ensembl
ENSRNOG00065008770
resolver
ensp
ENSRNOP00000078278
resolver
ensp
ENSRNOP00055013713
resolver
ensp
ENSRNOP00060034616
resolver
ensp
ENSRNOP00065010433
resolver
enst
ENSRNOT00000116844
resolver
enst
ENSRNOT00055017055
resolver
enst
ENSRNOT00060041758
resolver
enst
ENSRNOT00065013989
resolver
genesymbol
Atic
resolver
genesymbol_syn
Purh
resolver
uniprot
Q6IN16
resolver
uniprot_entry
PUR9_RAT
resolver
uniprot_sec
Q6IN16
resolver
activity_regulation
ACTIVITY REGULATION: AMP and XMP inhibit AICAR formyltransferase activity. {ECO:0000250|UniProtKB:P31939}.
uniprot
proteins
amino_acid_sequence
MASSQLALFSVSDKTGLVEFARNLASLGLSLVASGGTAKAIRDAGLAVRDVSELTGFPEMLGGRVKTLHPAVHAGILARNIPEDAADMARLDFNLIRVVVCNLYPFVKTVASPDVTVEAAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYGAVAAEMQGSGNKDTSLETRRHLALKAFTHTAQYDEAISDYFRRQYSKGISQMPLRYGMNPHQTPAQLYTLKPKLPITVLNGAPGFINLCDALNAWQLVTELRGAVDIPAAASFKHVSPAGAAVGVPLSEDEARVCMVYDLYPTLTPLAIAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIVAPGYEEEALKILSKKKNGSYCVLQMDQSYKPDENEVRTLFGLRLSQKRNNGVVDKSLFSNIVTKNKDLPESALRDLIVATIAVKYTQSNSVCYAKDGQVIGIGAGQQSRIHCTRLAGDKANSWWLRHHPRVLSMKFKAGVKRAEVSNAIDQYVTGTIGEGEDLVKWKALFEEVPELLTEAEKKEWVDKLSGVSVSSDAFFPFRDNVDRAKRSGVAYIVAPSGSTADKVVIEACDELGIVLAHTDLRLFHH
uniprot
proteins
ec_number
2.1.2.3
uniprot
proteins
ec_number
3.5.4.10
uniprot
proteins
function
FUNCTION: Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis. Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to inosine monophosphate (IMP) (By similarity). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). {ECO:0000250|UniProtKB:P31939, ECO:0000269|PubMed:25687571}.
uniprot
proteins
mass_dalton
64208
uniprot
proteins
pathway_participation
PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. {ECO:0000250|UniProtKB:P31939}.; PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1. {ECO:0000250|UniProtKB:P31939}.
uniprot
proteins
protein_family
PurH family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
25687571
uniprot
proteins
pubmed
9332377
uniprot
proteins
sequence_length
592
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P54113}.
uniprot
proteins