Ptpn4
entrez
19258
canonical
uniprot
Q9WU22
canonical
ensembl
ENSMUSG00000026384
resolver
ensp
ENSMUSP00000067614
resolver
ensp
ENSMUSP00000180376
resolver
ensp
ENSMUSP00000180381
resolver
enst
ENSMUST00000064091
resolver
genesymbol
Ptpn4
resolver
uniprot
G5E8E7
resolver
uniprot
Q8BQQ4
resolver
uniprot_entry
PTN4_MOUSE
resolver
uniprot_entry
Q8BQQ4_MOUSE
resolver
uniprot_sec
G5E8E7
resolver
amino_acid_sequence
MTARFRLPAGRTYNVRASELARDRQHTEVVCNILLLDNTVQAFRVNKHDQGQVLLDIVFKHLDLTERDYFGLQLADDSTDNPRWLDPNKPIRKQLKRGSPYNLNFRVKFFVSDPNKLQEEYTRYQYFLQIKQDILTGRLSCPCNTAALLASFAVQSELGDYNQSENLAGYLSDYSFIPNQPQDFEKEIAKLHQQHVGLSPAEAEFNYLNAARTLELYGVEFHYARDQSNNEILIGVMSGGILIYKNRVRMNTFLWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKTLWKACVEHHTFFRLDRPLPPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLARKLMDWEVVSRNSLSDDRLETQSLPSRSPPGTPNHRNSSFTQEATRVRPSSVGHLVDHVVHMSPSEDFVSQRSPSSTQANSIVLESSPSQETPEDGQPPALPPKQSKKNSWNQIHFSNSQQDLVTHTNESFDVPSSPEKSTPNGGIPHDNLVLIKMKPDENGRFGFNVKGGYDQKMPVIVSRVAPGTPADLCVPRLNEGDQVVLINGRDIAEHTHDQVVLFIKASCEKHSGELVLLVRPNAVYDVVEEKLESEPDFQYIPEKAPLDSVHQDDHSLRESMIQLAEGLITGTVLAQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVLLKGNEDYINANYINMEIPSSSIINQYIACQGPLPHTCKDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPSESSSYGCYQVTCHSEEGNPAYIFRKMTLFNQEKNESRQLTQIQYTAWPDHGVPDDSSDFLDFVCHVRDQRAGKEEPIIVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYEEGFVKPLTTSSNK
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Phosphatase that plays a role in immunity, learning, synaptic plasticity or cell homeostasis (PubMed:17953619, PubMed:25825441). Regulates neuronal cell homeostasis by protecting neurons against apoptosis (By similarity). Negatively regulates TLR4-induced interferon beta production by dephosphorylating adapter TICAM2 and inhibiting subsequent TRAM-TRIF interaction (PubMed:25825441). Dephosphorylates also the immunoreceptor tyrosine-based activation motifs/ITAMs of the TCR zeta subunit and thereby negatively regulates TCR-mediated signaling pathway (PubMed:18614237). May act at junctions between the membrane and the cytoskeleton. {ECO:0000250, ECO:0000250|UniProtKB:P29074, ECO:0000269|PubMed:17953619, ECO:0000269|PubMed:18614237, ECO:0000269|PubMed:25825441}.
uniprot
proteins
mass_dalton
105832
uniprot
proteins
protein_family
Non-receptor class subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
11054567
uniprot
proteins
pubmed
17953619
uniprot
proteins
pubmed
18614237
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25825441
uniprot
proteins
sequence_length
926
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}.
uniprot
proteins