Phactr1
entrez
218194
canonical
uniprot
Q2M3X8
canonical
ensembl
ENSMUSG00000054728
resolver
ensp
ENSMUSP00000105790
resolver
ensp
ENSMUSP00000115207
resolver
ensp
ENSMUSP00000115228
resolver
ensp
ENSMUSP00000122232
resolver
ensp
ENSMUSP00000123346
resolver
ensp
ENSMUSP00000158985
resolver
enst
ENSMUST00000131942
resolver
genesymbol
Phactr1
resolver
uniprot
B1B1B5
resolver
uniprot
B1B1B6
resolver
uniprot
B1B1B7
resolver
uniprot
B1B1B8
resolver
uniprot
G5E8P7
resolver
uniprot
Q3TLK1
resolver
uniprot
Q80VL9
resolver
uniprot
Q8C873
resolver
uniprot_entry
B1B1B8_MOUSE
resolver
uniprot_entry
PHAR1_MOUSE
resolver
uniprot_entry
Q3TLK1_MOUSE
resolver
uniprot_sec
B1B1B5
resolver
uniprot_sec
B1B1B6
resolver
uniprot_sec
B1B1B7
resolver
uniprot_sec
G5E8P7
resolver
uniprot_sec
Q80VL9
resolver
uniprot_sec
Q8C873
resolver
amino_acid_sequence
MDYPKMDYFLDVESAHRLLDVESAQRFFYSQGAQARRATLLLPPTLMAASSEDDIDRRPIRRVRSKSDTPYLAEARISFNLGAAEEVERLAAMRSDSLVPGTHTPPIRRRSKFANLGRIFKPWKWRKKKSEKFKHTSAALERKISMRQSREELIKRGVLKEIYDKDGELSISNEDDSLENGQSLSSSQLSLPALSEMEPVPMPRDPCSYEVLQASDIMDGPDPGAPVKLPCLPVKLSPPLPPKKVLICMPVGGPELTLASYAAQKSSQQAVAQHHHTVLPSQMQHQLQYGSHGQHLPSSTGTLPMHPSGCRMIDELNKTLAMTMQRLESSEQRVPCSTSYHSSGLHSSDGITKAGPMGLPEIRQVPTVVIECDDNKENVPHEPDYEDSPCLYGREEEEEEEDEDDDASLYTSSLAMKVCRKDSLAIKLSNRPSKRELEEKNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPRNEQEEQEEKREIKRRLTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADKPWTRLTAADKAAIRKELNEFKSTEMEVHELSRHLTRFHRP
uniprot
proteins
function
FUNCTION: Binds actin monomers (G actin) and plays a role in multiple processes including the regulation of actin cytoskeleton dynamics, actin stress fibers formation, cell motility and survival, formation of tubules by endothelial cells, and regulation of PPP1CA activity. Involved in the regulation of cortical neuron migration and dendrite arborization (PubMed:30256902). {ECO:0000250, ECO:0000269|PubMed:22976292, ECO:0000269|PubMed:23041370, ECO:0000269|PubMed:30256902}.
uniprot
proteins
mass_dalton
66286
uniprot
proteins
mutagenesis
MUTAGEN 108..110; /note="RRR->AAA: Abolishes nuclear import."; MUTAGEN 127..129; /note="KKK->AAA: Abolishes nuclear import."; MUTAGEN 147; /note="R->A: Reduces affinity for actin."; /evidence="ECO:0000269|PubMed:22976292"; MUTAGEN 431; /note="R->A: Constitutively nuclear; when associated with A-469 and A-507. Strongly reduced affinity for actin."; /evidence="ECO:0000269|PubMed:22976292"; MUTAGEN 459; /note="G->K: Increases affinity for actin."; /evidence="ECO:0000269|PubMed:23041370"; MUTAGEN 469; /note="R->A: Constitutively nuclear; when associated with A-431 and A-507. Strongly reduced affinity for actin."; /evidence="ECO:0000269|PubMed:22976292"; MUTAGEN 479; /note="N->I: Does not rescue cortical neuron migration defects in PHACTR1 knocked-down mice."; /evidence="ECO:0000269|PubMed:30256902"; MUTAGEN 496; /note="I->A: Reduces affinity for actin."; /evidence="ECO:0000269|PubMed:23041370"; MUTAGEN 500; /note="L->P: Does not rescue cortical neuron migration defects in PHACTR1 knocked-down mice."; /evidence="ECO:0000269|PubMed:30256902"; MUTAGEN 507; /note="R->A: Constitutively nuclear; when associated with A-431 and A-469. Strongly reduced affinity for actin."; /evidence="ECO:0000269|PubMed:22976292"; MUTAGEN 516; /note="R->A: Reduces affinity for actin."; /evidence="ECO:0000269|PubMed:23041370"; MUTAGEN 518; /note="I->N: Does not rescue cortical neuron migration defects in PHACTR1 knocked-down mice."; /evidence="ECO:0000269|PubMed:30256902"; MUTAGEN 521; /note="R->C: Does not rescue cortical neuron migration defects in PHACTR1 knocked-down mice."; /evidence="ECO:0000269|PubMed:30256902
uniprot
proteins
protein_family
Phosphatase and actin regulator family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16359841
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22976292
uniprot
proteins
pubmed
23041370
uniprot
proteins
pubmed
30256902
uniprot
proteins
sequence_length
580
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Synapse {ECO:0000250}. Nucleus. Note=Enriched at synapses (By similarity). Cytoplasmic in resting cells, and is imported into the nucleus upon serum stimulation. Interaction with actin prevents nuclear import. {ECO:0000250}.
uniprot
proteins