ASMT
entrez
438
canonical
uniprot
P46597
canonical
ensembl
ENSG00000196433
resolver
ensembl
ENSG00000292336
resolver
ensp
ENSP00000370627
resolver
ensp
ENSP00000370631
resolver
ensp
ENSP00000370639
resolver
ensp
ENSP00000518605
resolver
ensp
ENSP00000815731
resolver
ensp
ENSP00000815732
resolver
genesymbol
ASMT
resolver
hgnc
HGNC:750
resolver
uniprot
B2RC33
resolver
uniprot
Q16598
resolver
uniprot
Q5JQ72
resolver
uniprot
Q5JQ73
resolver
uniprot
X5D2A4
resolver
uniprot
X5D784
resolver
uniprot_entry
ASMT_HUMAN
resolver
uniprot_entry
X5D2A4_HUMAN
resolver
uniprot_entry
X5D784_HUMAN
resolver
uniprot_sec
B2RC33
resolver
uniprot_sec
Q16598
resolver
uniprot_sec
Q5JQ72
resolver
uniprot_sec
Q5JQ73
resolver
amino_acid_sequence
MGSSEDQAYRLLNDYANGFMVSQVLFAACELGVFDLLAEAPGPLDVAAVAAGVRASAHGTELLLDICVSLKLLKVETRGGKAFYRNTELSSDYLTTVSPTSQCSMLKYMGRTSYRCWGHLADAVREGRNQYLETFGVPAEELFTAIYRSEGERLQFMQALQEVWSVNGRSVLTAFDLSVFPLMCDLGGGAGALAKECMSLYPGCKITVFDIPEVVWTAKQHFSFQEEEQIDFQEGDFFKDPLPEADLYILARVLHDWADGKCSHLLERIYHTCKPGGGILVIESLLDEDRRGPLLTQLYSLNMLVQTEGQERTPTHYHMLLSSAGFRDFQFKKTGAIYDAILARK
uniprot
proteins
ec_number
2.1.1.4
uniprot
proteins
function
FUNCTION: [Isoform 1]: Catalyzes the transfer of a methyl group onto N-acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). {ECO:0000269|PubMed:22775292}.; FUNCTION: [Isoform 2]: Does not show Acetylserotonin O-methyltransferase activity. {ECO:0000269|PubMed:22775292}.; FUNCTION: [Isoform 3]: Does not show Acetylserotonin O-methyltransferase activity. {ECO:0000269|PubMed:22775292}.
uniprot
proteins
mass_dalton
38453
uniprot
proteins
mutagenesis
MUTAGEN 11; /note="L->F: Reduced enzyme activity."; /evidence="ECO:0000269|PubMed:22775292"; MUTAGEN 31; /note="L->H: No effect on enzyme activity."; MUTAGEN 111; /note="R->K: No effect on enzyme activity."; /evidence="ECO:0000269|PubMed:22775292"; MUTAGEN 248; /note="Y->H: Nearly abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:22775292"; MUTAGEN 296; /note="T->M: Nearly abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:22775292"; MUTAGEN 318; /note="H->D: Reduced enzyme activity."; /evidence="ECO:0000269|PubMed:22775292
uniprot
proteins
pathway_participation
PATHWAY: Aromatic compound metabolism; melatonin biosynthesis; melatonin from serotonin: step 1/2. {ECO:0000305|PubMed:22775292}.
uniprot
proteins
protein_family
Cation-independent O-methyltransferase family
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
17505466
uniprot
proteins
pubmed
17957233
uniprot
proteins
pubmed
21251267
uniprot
proteins
pubmed
21615493
uniprot
proteins
pubmed
22694957
uniprot
proteins
pubmed
22775292
uniprot
proteins
pubmed
23349736
uniprot
proteins
pubmed
7989373
uniprot
proteins
pubmed
8397829
uniprot
proteins
pubmed
8574683
uniprot
proteins
pubmed
8752109
uniprot
proteins
pubmed
8842389
uniprot
proteins
sequence_length
345
uniprot
proteins