Kcnn1
entrez
54261
canonical
uniprot
P70606
canonical
ensembl
ENSRNOG00000029264
resolver
ensembl
ENSRNOG00055010288
resolver
ensembl
ENSRNOG00060010593
resolver
ensembl
ENSRNOG00065023871
resolver
ensp
ENSRNOP00000042517
resolver
ensp
ENSRNOP00000073862
resolver
ensp
ENSRNOP00000108501
resolver
ensp
ENSRNOP00055013996
resolver
ensp
ENSRNOP00060013947
resolver
ensp
ENSRNOP00065033486
resolver
enst
ENSRNOT00000044291
resolver
enst
ENSRNOT00000142781
resolver
enst
ENSRNOT00055017398
resolver
enst
ENSRNOT00060017942
resolver
enst
ENSRNOT00065041005
resolver
genesymbol
Kcnn1
resolver
genesymbol_syn
Sk1
resolver
uniprot
A0A8L2QL77
resolver
uniprot
A0ABK0LCW1
resolver
uniprot_entry
A0A8L2QL77_RAT
resolver
uniprot_entry
A0ABK0LCW1_RAT
resolver
uniprot_entry
KCNN1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by bee venom neurotoxin apamin. Inhibited by d-tubocurarine and tetraethylammonium (TEA). {ECO:0000250|UniProtKB:Q92952}.
uniprot
proteins
amino_acid_sequence
MSSRSHNGSVGRPLGSGPGFLGWEPVDPEAGRPRQPTQGPGLQMMAKGQPAGLSPSGPRGHSQAQEEEEEEEDEDRPGSGKPPTVSHRLGHRRALFEKRKRLSDYALIFGMFGIVVMVTETELSWGVYTKESLCSFALKCLISLSTVILLGLVILYHAREIQLFLVDNGADDWRIAMTWERVSLISLELAVCAIHPVPGHYRFTWTARLAFSLVPSAAEADVDVLLSIPMFLRLYLLARVMLLHSRIFTDASSRSIGALNRVTFNTRFVTKTLMTICPGTVLLVFSISSWIVAAWTVRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQSRVRKHQRKFLQAIHQAQKLRTVKIEQGKVNDQANTLADLAKAQSIAYEVVSELQAQQEELEARLAALESRLDVLGASLQALPSLIAQAICPLPPPWPGPSHLTTAAQSPQSHWLPTTASDCG
uniprot
proteins
function
FUNCTION: Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening (By similarity). The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of about 3 picosiemens (By similarity). Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values, above + 20 mV (By similarity). Activation is followed by membrane hyperpolarization (By similarity). Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization (By similarity). {ECO:0000250|UniProtKB:Q92952, ECO:0000250|UniProtKB:Q9EQR3}.
uniprot
proteins
mass_dalton
59215
uniprot
proteins
protein_family
KCa2.1/KCNN1 subfamily
uniprot
proteins
protein_family
Potassium channel KCNN family
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
8781233
uniprot
proteins
pubmed
9380751
uniprot
proteins
sequence_length
536
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:Q9EQR3}.
uniprot
proteins
transmembrane_region
TRANSMEM 107..127; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 136..156; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 224..244; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 273..293; /note="Helical; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 313..333; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 487..507; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins