Tap2
entrez
24812
canonical
uniprot
P36372
canonical
ensembl
ENSRNOG00000000455
resolver
ensp
ENSRNOP00000000527
resolver
enst
ENSRNOT00000000527
resolver
genesymbol
Tap2
resolver
genesymbol_syn
Abcb3
resolver
genesymbol_syn
Mtp2
resolver
uniprot
A6JJD9
resolver
uniprot
F7EQQ0
resolver
uniprot
Q6MGA3
resolver
uniprot_entry
F7EQQ0_RAT
resolver
uniprot_entry
Q6MGA3_RAT
resolver
uniprot_entry
TAP2_RAT
resolver
uniprot_sec
A6JJD9
resolver
amino_acid_sequence
MALSHPRPWASLLLVDLALLGLLQSSLGTLLPPGLPGLWLEGTLRLGVLWGLLKVGGLLRLVGTFLPLLCLTNPLFFSLRALVGSTMSTSVVRVASASWGWLLADYGAVALSLAVWAVLSPAGAQEKEPGQENNRALMIRLLRLSKPDLPFLIVAFIFLAMAVWWEMFIPHYSGRVIDILGGDFDPDAFASAIFFMCLFSVGSSLSAGCRGGSFLFAESRINLRIREQLFSSLLRQDLAFFQETKTGELNSRLSSDTSLMSQWLSLNANILLRSLVKVVGLYYFMLQVSPRLTFLSLLDLPLTIAAEKVYNPRHQAVLKEIQDAVAKAGQVVREAVGGLQTVRSFGAEEQEVRRYKEALERCRQLWWRRDLEKSLYLVIQRVMALGMQVLILNVGVQQILAGEVTRGGLLSFLLYQEEVGHHVQNLVYMYGDMLSNVGAAEKVFSYLDRRPNLPNPGTLAPPRLEGRVEFQDVSFSYPSRPEKPVLQGLTFTLHPGKVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGEPLVQYDHHYLHRQVVLVGQEPVLFSGSVKDNIAYGLRDCEDAQVMAAAQAACADDFIGEMTNGINTEIGEKGSQLAVGQKQRLAIARALVRNPRVLILDEATSALDAECEQALQTWRSQEDRTMLVIAHRLHTVQNADQVLVLKQGQLVEHDQLRDEQDVYAHLVQQRLEA
uniprot
proteins
ec_number
7.4.2.14
uniprot
proteins
function
FUNCTION: ABC transporter associated with antigen processing (PubMed:17018292). In complex with TAP1 mediates unidirectional translocation of peptide antigens from cytosol to endoplasmic reticulum (ER) for loading onto MHC class I (MHCI) molecules (By similarity). Uses the chemical energy of ATP to export peptides against the concentration gradient (By similarity). During the transport cycle alternates between 'inward-facing' state with peptide binding site facing the cytosol to 'outward-facing' state with peptide binding site facing the ER lumen. Peptide antigen binding to ATP-loaded TAP1-TAP2 induces a switch to hydrolysis-competent 'outward-facing' conformation ready for peptide loading onto nascent MHCI molecules. Subsequently ATP hydrolysis resets the transporter to the 'inward facing' state for a new cycle (By similarity). As a component of the peptide loading complex (PLC), acts as a molecular scaffold essential for peptide-MHCI assembly and antigen presentation (By similarity). {ECO:0000250|UniProtKB:Q03519, ECO:0000269|PubMed:17018292}.
uniprot
proteins
mass_dalton
77713
uniprot
proteins
mutagenesis
MUTAGEN 608..609; /note="AV->SG: Has negligible effect on ATPase activity."; /evidence="ECO:0000269|PubMed:17018292"; MUTAGEN 632; /note="E->D: Impairs peptide loading onto MHCI."; /evidence="ECO:0000269|PubMed:17018292"; MUTAGEN 632; /note="E->Q: Has negligible effect on ATPase activity."; /evidence="ECO:0000269|PubMed:17018292
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCB family
uniprot
proteins
protein_family
MHC peptide exporter (TC 3.A.1.209) subfamily
uniprot
proteins
pubmed
1350326
uniprot
proteins
pubmed
17018292
uniprot
proteins
pubmed
1758495
uniprot
proteins
pubmed
8206525
uniprot
proteins
sequence_length
703
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q03519}; Multi-pass membrane protein {ECO:0000255}. Note=The transmembrane segments seem to form a pore in the membrane. {ECO:0000250|UniProtKB:Q03519}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..27; /note="Helical; Name=1"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 57..77; /note="Helical; Name=2"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 99..119; /note="Helical; Name=3"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 149..169; /note="Helical; Name=4"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 188..208; /note="Helical; Name=5"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 267..287; /note="Helical; Name=6"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 294..314; /note="Helical; Name=7"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 375..395; /note="Helical; Name=8"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 409..429; /note="Helical; Name=9"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441
uniprot
proteins