DRC9
entrez
84223
canonical
uniprot
Q9H095
canonical
ensembl
ENSG00000114473
resolver
ensp
ENSP00000265239
resolver
ensp
ENSP00000389897
resolver
ensp
ENSP00000407736
resolver
ensp
ENSP00000530835
resolver
enst
ENST00000453254
resolver
genesymbol
DRC9
resolver
genesymbol_syn
IQCG
resolver
hgnc
HGNC:25251
resolver
uniprot
C9JKX8
resolver
uniprot
Q9BST2
resolver
uniprot
Q9H5C8
resolver
uniprot
Q9HAG8
resolver
uniprot_entry
C9JKX8_HUMAN
resolver
uniprot_entry
DRC9_HUMAN
resolver
uniprot_entry
Q9H5C8_HUMAN
resolver
uniprot_sec
Q9BST2
resolver
uniprot_sec
Q9HAG8
resolver
amino_acid_sequence
MEEDSLEDSNLPPKVWHSEMTVSVTGEPPSTVEEEGIPKETDIEIIPEIPETLEPLSLPDVLRISAVLEDTTDQLSILNYIMPVQYEGRQSICVKSREMNLEGTNLDKLPMASTITKIPSPLITEEGPNLPEIRHRGRFAVEFNKMQDLVFKKPTRQTIMTTETLKKIQIDRQFFSDVIADTIKELQDSATYNSLLQALSKERENKMHFYDIIAREEKGRKQIISLQKQLINVKKEWQFEVQSQNEYIANLKDQLQEMKAKSNLENRYMKTNTELQIAQTQKKCNRTEELLVEEIEKLRMKTEEEARTHTEIEMFLRKEQQKLEERLEFWMEKYDKDTEMKQNELNALKATKASDLAHLQDLAKMIREYEQVIIEDRIEKERSKKKVKQDLLELKSVIKLQAWWRGTMIRREIGGFKMPKDKVDSKDSKGKGKGKDKRRGKKK
uniprot
proteins
function
FUNCTION: Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when cellular Ca(2+) levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades. Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility. {ECO:0000250|UniProtKB:A3KQH2, ECO:0000250|UniProtKB:A8HQ54, ECO:0000250|UniProtKB:Q80W32}.
uniprot
proteins
mass_dalton
51918
uniprot
proteins
mutagenesis
MUTAGEN 401; /note="Q->A: Loss of calmodulin binding."; /evidence="ECO:0000269|PubMed:24787902
uniprot
proteins
protein_family
DRC9 family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24787902
uniprot
proteins
sequence_length
443
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24787902}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q80W32}. Cell projection, cilium {ECO:0000250|UniProtKB:Q80W32}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q80W32}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:A8HQ54}. Note=First detected in the cytoplasm of pachytene spermatocytes. Colocalizes with alpha-tubulin at the manchette in developing spermatids. Detected in the flagellum of mature testicular spermatozoa, and in the flagellum and post-acrosomal region of the head of epididymal spermatozoa. Detected in cilia in trachea and oviduct. {ECO:0000250|UniProtKB:Q80W32}.
uniprot
proteins