DDO
entrez
8528
canonical
uniprot
Q99489
canonical
ensembl
ENSG00000203797
resolver
ensp
ENSP00000357919
resolver
ensp
ENSP00000357920
resolver
ensp
ENSP00000779209
resolver
ensp
ENSP00000785315
resolver
genesymbol
DDO
resolver
genesymbol
ddo
resolver
hgnc
HGNC:2727
resolver
uniprot
A8KAG4
resolver
uniprot
C9K4X7
resolver
uniprot
Q5JXM4
resolver
uniprot
Q5JXM5
resolver
uniprot
Q5JXM6
resolver
uniprot
Q8N552
resolver
uniprot_entry
C9K4X7_HUMAN
resolver
uniprot_entry
OXDD_HUMAN
resolver
uniprot_sec
A8KAG4
resolver
uniprot_sec
Q5JXM4
resolver
uniprot_sec
Q5JXM5
resolver
uniprot_sec
Q5JXM6
resolver
uniprot_sec
Q8N552
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by the benzodiazepine olanzapine (PubMed:28393897). Inhibited by aminooxyacetic acid, thiolactomycin, malonate and meso-tartrate (PubMed:20603179, PubMed:23391306, PubMed:25747990). Clozapine, haloperidol and chlorpromazine have no effect on activity (PubMed:28393897, PubMed:28560262). Not inhibited by sodium, potassium, magnesium, iron, calcium, cobalt, copper, nickel, manganese or zinc ions (PubMed:25747990). Not inhibited by AMP, ADP, ATP, or cAMP (PubMed:25747990). Not inhibited by pyridoxal 5'-phosphate (PubMed:25747990). {ECO:0000269|PubMed:20603179, ECO:0000269|PubMed:23391306, ECO:0000269|PubMed:25747990, ECO:0000269|PubMed:28393897, ECO:0000269|PubMed:28560262}.
uniprot
proteins
amino_acid_sequence
MDTARIAVVGAGVVGLSTAVCISKLVPRCSVTIISDKFTPDTTSDVAAGMLIPHTYPDTPIHTQKQWFRETFNHLFAIANSAEAGDAGVHLVSGWQIFQSTPTEEVPFWADVVLGFRKMTEAELKKFPQYVFGQAFTTLKCECPAYLPWLEKRIKGSGGWTLTRRIEDLWELHPSFDIVVNCSGLGSRQLAGDSKIFPVRGQVLQVQAPWVEHFIRDGSGLTYIYPGTSHVTLGGTRQKGDWNLSPDAENSREILSRCCALEPSLHGACNIREKVGLRPYRPGVRLQTELLARDGQRLPVVHHYGHGSGGISVHWGTALEAARLVSECVHALRTPIPKSNL
uniprot
proteins
ec_number
1.4.3.1
uniprot
proteins
function
FUNCTION: Selectively catalyzes the oxidative deamination of acidic amino acids (PubMed:1991137, PubMed:20603179, PubMed:23391306, PubMed:25747990, PubMed:28393897, PubMed:28560262, PubMed:28629864, PubMed:29292239, PubMed:31914658, PubMed:32553892, PubMed:9163533). Suppresses the level of D-aspartate in the brain, an amino acid that can act as an agonist for glutamate receptors (PubMed:28560262). Protects the organism from the toxicity of D-amino acids (By similarity). May also function in the intestine (By similarity). {ECO:0000250|UniProtKB:D3ZDM7, ECO:0000250|UniProtKB:Q922Z0, ECO:0000269|PubMed:1991137, ECO:0000269|PubMed:20603179, ECO:0000269|PubMed:23391306, ECO:0000269|PubMed:25747990, ECO:0000269|PubMed:28393897, ECO:0000269|PubMed:28560262, ECO:0000269|PubMed:28629864, ECO:0000269|PubMed:29292239, ECO:0000269|PubMed:31914658, ECO:0000269|PubMed:32553892, ECO:0000269|PubMed:9163533}.
uniprot
proteins
mass_dalton
37535
uniprot
proteins
mutagenesis
MUTAGEN 141..143; /note="CEC->YEG: Slightly decreases activity."; /evidence="ECO:0000269|PubMed:31914658
uniprot
proteins
post_translational_modification
PTM: May be S-nitrosylated. {ECO:0000269|PubMed:37805834}.
uniprot
proteins
protein_family
DAMOX/DASOX family
uniprot
proteins
pubmed
12209855
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
1991137
uniprot
proteins
pubmed
20603179
uniprot
proteins
pubmed
23391306
uniprot
proteins
pubmed
25689573
uniprot
proteins
pubmed
25747990
uniprot
proteins
pubmed
28393897
uniprot
proteins
pubmed
28560262
uniprot
proteins
pubmed
28629864
uniprot
proteins
pubmed
29292239
uniprot
proteins
pubmed
30822420
uniprot
proteins
pubmed
31914658
uniprot
proteins
pubmed
32553892
uniprot
proteins
pubmed
33650155
uniprot
proteins
pubmed
37805834
uniprot
proteins
pubmed
9163533
uniprot
proteins
pubmed
9820813
uniprot
proteins
sequence_length
341
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome matrix {ECO:0000269|PubMed:1991137, ECO:0000269|PubMed:37805834}. Cytoplasm, cytosol {ECO:0000269|PubMed:37805834}. Note=Active in the peroxisomal matrix. {ECO:0000269|PubMed:37805834}.; SUBCELLULAR LOCATION: [Isoform DDO-1]: Peroxisome matrix {ECO:0000269|PubMed:33650155}.; SUBCELLULAR LOCATION: [Isoform 3]: Peroxisome matrix {ECO:0000269|PubMed:33650155}.
uniprot
proteins