Bex1
entrez
19716
canonical
uniprot
Q9R224
canonical
ensembl
ENSMUSG00000050071
resolver
ensp
ENSMUSP00000060005
resolver
ensp
ENSMUSP00000108743
resolver
ensp
ENSMUSP00000108745
resolver
enst
ENSMUST00000058125
resolver
enst
ENSMUST00000113118
resolver
enst
ENSMUST00000113120
resolver
genesymbol
Bex1
resolver
genesymbol_syn
Rex3
resolver
uniprot
A3KGA2
resolver
uniprot
O88858
resolver
uniprot
Q9R1J2
resolver
uniprot_entry
BEX1_MOUSE
resolver
uniprot_sec
A3KGA2
resolver
uniprot_sec
O88858
resolver
uniprot_sec
Q9R1J2
resolver
amino_acid_sequence
MESKDQGVKNLNMENDHQKKEEKEEKPQDTIRREPAVALTSEAGKNCAPRGGRRRFRVRQPIAHYRWDLMQRVGEPQGRMREENVQRFGGDVRQLMEKLRERQLSHSLRAVSTDPPHHDHHDEFCLMP
uniprot
proteins
function
FUNCTION: Signaling adapter molecule involved in p75NTR/NGFR signaling (By similarity). Plays a role in cell cycle progression and neuronal differentiation (By similarity). Inhibits neuronal differentiation in response to nerve growth factor (NGF) (By similarity). May act as a link between the cell cycle and neurotrophic factor signaling, possibly by functioning as an upstream modulator of receptor signaling, coordinating biological responses to external signals with internal cellular states (By similarity). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (PubMed:34562363). {ECO:0000250|UniProtKB:Q3MKQ2, ECO:0000269|PubMed:34562363}.
uniprot
proteins
mass_dalton
15119
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation of Ser-105 protects it from the proteasome. {ECO:0000250|UniProtKB:Q3MKQ2}.; PTM: Ubiquitinated. Degraded by the proteasome. {ECO:0000250|UniProtKB:Q3MKQ2}.
uniprot
proteins
protein_family
BEX family
uniprot
proteins
pubmed
10072429
uniprot
proteins
pubmed
11989783
uniprot
proteins
pubmed
12054873
uniprot
proteins
pubmed
12911636
uniprot
proteins
pubmed
15198671
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15861462
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
34562363
uniprot
proteins
pubmed
9806360
uniprot
proteins
sequence_length
128
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12911636}. Cytoplasm {ECO:0000269|PubMed:12911636}. Note=Shuttles between the cytoplasm and the nucleus. Predominantly nuclear. {ECO:0000269|PubMed:12911636}.
uniprot
proteins