Emc2
entrez
362905
canonical
uniprot
B0BNG0
canonical
ensembl
ENSRNOG00000005123
resolver
ensp
ENSRNOP00000088541
resolver
enst
ENSRNOT00000115694
resolver
genesymbol
Emc2
resolver
genesymbol_syn
Ttc35
resolver
uniprot_entry
EMC2_RAT
resolver
amino_acid_sequence
MAKVTERYDVTWEEMRDKMRKWREENSRNSEQIMEVGEELINDYASKLGDDIWIIYEQVMIAALDYGRDDLALFCLQELRRQFPGSHRVKRLTGMRFEAMERYDDAIQLYDRILQEDPTNTAARKRKIAIRKAQGKNVEAIRELNEYLEQFVGDQEAWHELAELYINEHDYAKAAFCLEELMMTNPHNHLYCQQYAEVKYTQGGLENLELSRKYFAQALKLNNRNMRALFGLYMSASHIASNPKASAKMKKDNIRYAGWAANQINRAYQFAGRSKKETKSSLKAVEDMLETLQITQS
uniprot
proteins
function
FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. {ECO:0000250|UniProtKB:Q15006}.
uniprot
proteins
mass_dalton
34870
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated when soluble in the cytoplasm, leading to its degradation by the proteasome. Interaction with EMC2 prevents its ubiquitination and degradation. {ECO:0000250|UniProtKB:Q15006}.
uniprot
proteins
protein_family
EMC2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
297
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q15006}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q15006}; Cytoplasmic side {ECO:0000250|UniProtKB:Q15006}. Note=May also localize to the nuclear envelope. {ECO:0000250|UniProtKB:Q9CRD2}.
uniprot
proteins