Fbp2
entrez
114508
canonical
uniprot
Q9Z1N1
canonical
ensembl
ENSRNOG00000017637
resolver
ensembl
ENSRNOG00055023493
resolver
ensembl
ENSRNOG00060017963
resolver
ensembl
ENSRNOG00065021884
resolver
ensp
ENSRNOP00000023865
resolver
ensp
ENSRNOP00055032799
resolver
ensp
ENSRNOP00060024955
resolver
ensp
ENSRNOP00065030053
resolver
enst
ENSRNOT00000023865
resolver
enst
ENSRNOT00055040370
resolver
enst
ENSRNOT00060030817
resolver
enst
ENSRNOT00065037247
resolver
genesymbol
Fbp2
resolver
uniprot_entry
F16P2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Subject to complex allosteric regulation. The enzyme can assume an active R-state, or an inactive T-state. Intermediate conformations may exist. AMP acts as an allosteric inhibitor. Fructose 2,6-bisphosphate acts as a competitive inhibitor. Strongly inhibited by Ca(2+) (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MTDRSPFETDMLTLTRYVMEKGRQAKGTGELTQLLNSMLTAIKAISSAVRKAGLANLYGIAGSVNVTGDEVKKLDVLSNSLVINMLQSSYSTCVLVSEENKEAVITAKERRGKYVVCFDPLDGSSNIDCLASIGTIFAIYRKTTEDEPSEKDALQPGRNIVAAGYALYGSATLVALSTGQGVDLFMLDPALGEFVLVEKDIRIKKKGKIFSLNEGYAKYFDAATAEYVQKKKFPEDGSAPYGARYVGSMVADVHRTLVYGGIFMYPANQKSPNGKLRLLYECNPVAYIIEQAGGMATTGTQPVLDVKPESIHQRVPLILGSPEDVQEYLSCVQRNQAGR
uniprot
proteins
ec_number
3.1.3.11
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate.
uniprot
proteins
mass_dalton
36887
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate biosynthesis; gluconeogenesis.
uniprot
proteins
protein_family
FBPase class 1 family
uniprot
proteins
pubmed
16814784
uniprot
proteins
pubmed
21046014
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
339
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction. Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere, Z line. Note=In neonatal cardiomyocytes, distributed throughout the cytosol, accumulating in the intercalated disks which occur at the Z line of cardiomyocytes and connect adjacent cells, and also located in the nucleus; dissociates from the Z line following an increase in cytosolic Ca(2+) concentration. In muscle precursor cells, localizes predominantly to the nucleus and to a lesser extent to the cytoplasm at the proliferative phase, while mainly localizing to the cytoplasm at the differentiation phase. Colocalizes with ALDOA and alpha-actinin on both sides of the Z line of skeletal muscle; dissociates rapidly from the Z line following an increase in cytosolic Ca(2+) concentration.
uniprot
proteins