Cplx1
entrez
12889
canonical
uniprot
P63040
canonical
ensembl
ENSMUSG00000033615
resolver
ensp
ENSMUSP00000038502
resolver
enst
ENSMUST00000046892
resolver
genesymbol
Cplx1
resolver
uniprot
O09057
resolver
uniprot
O09142
resolver
uniprot
Q3UYB3
resolver
uniprot
Q64276
resolver
uniprot
Q91WJ3
resolver
uniprot_entry
CPLX1_MOUSE
resolver
uniprot_sec
O09057
resolver
uniprot_sec
O09142
resolver
uniprot_sec
Q3UYB3
resolver
uniprot_sec
Q64276
resolver
uniprot_sec
Q91WJ3
resolver
amino_acid_sequence
MEFVMKQALGGATKDMGKMLGGDEEKDPDAAKKEEERQEALRQAEEERKAKYAKMEAEREVMRQGIRDKYGIKKKEEREAEAQAAMEANSEGSLTRPKKAIPPGCGDEPEEEDESILDTVIKYLPGPLQDMFKK
uniprot
proteins
function
FUNCTION: Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles (PubMed:23345244). Organizes the SNAREs into a cross-linked zigzag topology that, when interposed between the vesicle and plasma membranes, is incompatible with fusion, thereby preventing SNAREs from releasing neurotransmitters until an action potential arrives at the synapse (PubMed:23345244). Also involved in glucose-induced secretion of insulin by pancreatic beta-cells. Essential for motor behavior (PubMed:15126625, PubMed:16000319). {ECO:0000269|PubMed:15126625, ECO:0000269|PubMed:16000319, ECO:0000269|PubMed:23345244}.
uniprot
proteins
mass_dalton
15122
uniprot
proteins
protein_family
Complexin/synaphin family
uniprot
proteins
pubmed
15126625
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15911881
uniprot
proteins
pubmed
16000319
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23345244
uniprot
proteins
pubmed
7635198
uniprot
proteins
sequence_length
134
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:15126625, ECO:0000269|PubMed:7635198}. Perikaryon {ECO:0000269|PubMed:7635198}. Presynapse {ECO:0000269|PubMed:7635198}. Note=Enriched at synaptic-releasing sites in mature neurons. {ECO:0000269|PubMed:7635198}.
uniprot
proteins