GINS4
entrez
84296
canonical
uniprot
Q9BRT9
canonical
ensembl
ENSG00000147536
resolver
ensp
ENSP00000276533
resolver
ensp
ENSP00000428754
resolver
genesymbol
GINS4
resolver
genesymbol_syn
SLD5
resolver
hgnc
HGNC:28226
resolver
uniprot
B2R8H5
resolver
uniprot
D3DSY0
resolver
uniprot
Q8N648
resolver
uniprot_entry
SLD5_HUMAN
resolver
uniprot_sec
B2R8H5
resolver
uniprot_sec
D3DSY0
resolver
uniprot_sec
Q8N648
resolver
amino_acid_sequence
MTEEVDFLGQDSDGGSEEVVLTPAELIERLEQAWMNEKFAPELLESKPEIVECVMEQLEHMEENLRRAKREDLKVSIHQMEMERIRYVLSSYLRCRLMKIEKFFPHVLEKEKTRPEGEPSSLSPEELAFAREFMANTESYLKNVALKHMPPNLQKVDLFRAVPKPDLDSYVFLRVRERQENILVEPDTDEQRDYVIDLEKGSQHLIRYKTIAPLVASGAVQLI
uniprot
proteins
function
FUNCTION: Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks (PubMed:17417653, PubMed:28414293). GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). {ECO:0000269|PubMed:17417653, ECO:0000269|PubMed:28414293, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232}.
uniprot
proteins
mass_dalton
26047
uniprot
proteins
protein_family
GINS4/SLD5 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17170760
uniprot
proteins
pubmed
17417653
uniprot
proteins
pubmed
17545466
uniprot
proteins
pubmed
17557111
uniprot
proteins
pubmed
17611626
uniprot
proteins
pubmed
17652513
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
28414293
uniprot
proteins
pubmed
32453425
uniprot
proteins
pubmed
34694004
uniprot
proteins
pubmed
34700328
uniprot
proteins
pubmed
35585232
uniprot
proteins
sequence_length
223
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:35585232}. Chromosome {ECO:0000305|PubMed:35585232}. Cytoplasm {ECO:0000250|UniProtKB:Q99LZ3}. Note=Associates with chromatin. {ECO:0000305|PubMed:35585232}.
uniprot
proteins