AOC1
entrez
26
canonical
uniprot
P19801
canonical
ensembl
ENSG00000002726
resolver
ensp
ENSP00000354193
resolver
ensp
ENSP00000411613
resolver
ensp
ENSP00000418328
resolver
ensp
ENSP00000534052
resolver
ensp
ENSP00000611468
resolver
genesymbol
AOC1
resolver
genesymbol_syn
ABP
resolver
genesymbol_syn
ABP1
resolver
genesymbol_syn
DAO
resolver
hgnc
HGNC:80
resolver
uniprot
C9J690
resolver
uniprot
Q16683
resolver
uniprot
Q16684
resolver
uniprot
Q56II4
resolver
uniprot
Q6GU42
resolver
uniprot_entry
AOC1_HUMAN
resolver
uniprot_sec
C9J690
resolver
uniprot_sec
Q16683
resolver
uniprot_sec
Q16684
resolver
uniprot_sec
Q56II4
resolver
uniprot_sec
Q6GU42
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by amiloride and amiloride analogs (PubMed:8144586). Inhibited by isoniazid, cimetidine, clonidine, berenil and pentamidine (PubMed:19764817). {ECO:0000269|PubMed:19764817, ECO:0000269|PubMed:8144586}.
uniprot
proteins
amino_acid_sequence
MPALGWAVAAILMLQTAMAEPSPGTLPRKAGVFSDLSNQELKAVHSFLWSKKELRLQPSSTTTMAKNTVFLIEMLLPKKYHVLRFLDKGERHPVREARAVIFFGDQEHPNVTEFAVGPLPGPCYMRALSPRPGYQSSWASRPISTAEYALLYHTLQEATKPLHQFFLNTTGFSFQDCHDRCLAFTDVAPRGVASGQRRSWLIIQRYVEGYFLHPTGLELLVDHGSTDAGHWAVEQVWYNGKFYGSPEELARKYADGEVDVVVLEDPLPGGKGHDSTEEPPLFSSHKPRGDFPSPIHVSGPRLVQPHGPRFRLEGNAVLYGGWSFAFRLRSSSGLQVLNVHFGGERIAYEVSVQEAVALYGGHTPAGMQTKYLDVGWGLGSVTHELAPGIDCPETATFLDTFHYYDADDPVHYPRALCLFEMPTGVPLRRHFNSNFKGGFNFYAGLKGQVLVLRTTSTVYNYDYIWDFIFYPNGVMEAKMHATGYVHATFYTPEGLRHGTRLHTHLIGNIHTHLVHYRVDLDVAGTKNSFQTLQMKLENITNPWSPRHRVVQPTLEQTQYSWERQAAFRFKRKLPKYLLFTSPQENPWGHKRTYRLQIHSMADQVLPPGWQEEQAITWARYPLAVTKYRESELCSSSIYHQNDPWHPPVVFEQFLHNNENIENEDLVAWVTVGFLHIPHSEDIPNTATPGNSVGFLLRPFNFFPEDPSLASRDTVIVWPRDNGPNYVQRWIPEDRDCSMPPPFSYNGTYRPV
uniprot
proteins
ec_number
1.4.3.22
uniprot
proteins
function
FUNCTION: Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia (PubMed:12072962, PubMed:19764817, PubMed:239684, PubMed:8144586). Its preferred substrates are the diamines histamine and 1-methylhistamine and it could therefore play a role in allergic and immune responses (PubMed:12072962). Has a broad specificity for diamines and can also act on cadaverine and putrescine, two products of amino acid catabolism (PubMed:12072962). It could also act on polyamines, like spermidine and spermine though less efficiently, and regulate various biological processes (PubMed:12072962, PubMed:239684). {ECO:0000269|PubMed:12072962, ECO:0000269|PubMed:19764817, ECO:0000269|PubMed:239684, ECO:0000269|PubMed:8144586}.
uniprot
proteins
mass_dalton
85378
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:12072962, ECO:0000269|PubMed:19764817}.; PTM: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. {ECO:0000250|UniProtKB:P12807}.
uniprot
proteins
protein_family
Copper/topaquinone oxidase family
uniprot
proteins
pubmed
12072962
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19764817
uniprot
proteins
pubmed
2217167
uniprot
proteins
pubmed
239684
uniprot
proteins
pubmed
8144586
uniprot
proteins
pubmed
8182053
uniprot
proteins
pubmed
8595053
uniprot
proteins
sequence_length
751
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000269|PubMed:8144586}. Cell membrane {ECO:0000269|PubMed:8144586}; Peripheral membrane protein {ECO:0000305|PubMed:8144586}; Extracellular side {ECO:0000305|PubMed:8144586}.
uniprot
proteins