CTIF
entrez
9811
canonical
uniprot
O43310
canonical
ensembl
ENSG00000134030
resolver
ensembl
ENSG00000282825
resolver
ensp
ENSP00000256413
resolver
ensp
ENSP00000372459
resolver
ensp
ENSP00000535587
resolver
ensp
ENSP00000535588
resolver
ensp
ENSP00000535592
resolver
ensp
ENSP00000535593
resolver
ensp
ENSP00000535594
resolver
ensp
ENSP00000535595
resolver
ensp
ENSP00000535597
resolver
ensp
ENSP00000535598
resolver
ensp
ENSP00000582241
resolver
ensp
ENSP00000629103
resolver
ensp
ENSP00000629105
resolver
ensp
ENSP00000629107
resolver
ensp
ENSP00000629110
resolver
ensp
ENSP00000629112
resolver
ensp
ENSP00000629114
resolver
genesymbol
CTIF
resolver
genesymbol_syn
KIAA0427
resolver
hgnc
HGNC:23925
resolver
uniprot
B3KTR8
resolver
uniprot
Q8IVD5
resolver
uniprot_entry
CTIF_HUMAN
resolver
uniprot_sec
B3KTR8
resolver
uniprot_sec
Q8IVD5
resolver
amino_acid_sequence
MENSSAASASSEAGSSRSQEIEELERFIDSYVLEYQVQGLLADKTEGDGESERTQSHISQWTADCSEPLDSSCSFSRGRAPPQQNGSKDNSLDMLGTDIWAANTFDSFSGATWDLQPEKLDFTQFHRKVRHTPKQPLPHIDREGCGKGKLEDGDGINLNDIEKVLPAWQGYHPMPHEVEIAHTKKLFRRRRNDRRRQQRPPGGNKPQQHGDHQPGSAKHNRDHQKSYQGGSAPHPSGRPTHHGYSQNRRWHHGNMKHPPGDKGEAGAHRNAKETMTIENPKLEDTAGDTGHSSLEAPRSPDTLAPVASERLPPQQSGGPEVETKRKDSILPERIGERPKITLLQSSKDRLRRRLKEKDEVAVETTTPQQNKMDKLIEILNSMRNNSSDVDTKLTTFMEEAQNSTNSEEMLGEIVRTIYQKAVSDRSFAFTAAKLCDKMALFMVEGTKFRSLLLNMLQKDFTVREELQQQDVERWLGFITFLCEVFGTMRSSTGEPFRVLVCPIYTCLRELLQSQDVKEDAVLCCSMELQSTGRLLEEQLPEMMTELLASARDKMLCPSESMLTRSLLLEVIELHANSWNPLTPPITQYYNRTIQKLTA
uniprot
proteins
function
FUNCTION: Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD). {ECO:0000269|PubMed:19648179}.
uniprot
proteins
mass_dalton
67587
uniprot
proteins
protein_family
CTIF family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19648179
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9455477
uniprot
proteins
sequence_length
598
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:19648179}.
uniprot
proteins