Nkx6-1
entrez
18096
canonical
uniprot
Q99MA9
canonical
ensembl
ENSMUSG00000035187
resolver
ensp
ENSMUSP00000042716
resolver
enst
ENSMUST00000044125
resolver
genesymbol
Nkx6-1
resolver
genesymbol_syn
Nkx6.1
resolver
genesymbol_syn
Nkx6a
resolver
uniprot
B2RQP4
resolver
uniprot
Q9ERQ7
resolver
uniprot_entry
NKX61_MOUSE
resolver
uniprot_sec
B2RQP4
resolver
uniprot_sec
Q9ERQ7
resolver
amino_acid_sequence
MLAVGAMEGPRQSAFLLSSPPLAALHSMAEMKTPLYPAAYPPLPTGPPSSSSSSSSSSSPSPPLGSHNPGGLKPPAAGGLSSLGSPPQQLSAATPHGINDILSRPSMPVASGAALPSASPSGSSSSSSSSASATSASAAAAAAAAAAAAAASSPAGLLAGLPRFSSLSPPPPPPGLYFSPSAAAVAAVGRYPKPLAELPGRTPIFWPGVMQSPPWRDARLACTPHQGSILLDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKKHAAEMATAKKKQDSETERLKGTSENEEDDDDYNKPLDPNSDDEKITQLLKKHKSSGGSLLLHASEAEGSS
uniprot
proteins
function
FUNCTION: Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Required for the development of insulin-producing beta cells in the islets of Langerhans at the secondary transition (PubMed:11076772). Involved in transcriptional regulation of the insulin gene. Together with NKX2-2 and IRX3, restricts the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals. {ECO:0000269|PubMed:10830170, ECO:0000269|PubMed:11076772}.
uniprot
proteins
mass_dalton
37705
uniprot
proteins
pubmed
10830170
uniprot
proteins
pubmed
10938085
uniprot
proteins
pubmed
11076772
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
365
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11076772}.
uniprot
proteins