CDC14B
entrez
8555
canonical
uniprot
O60729
canonical
ensembl
ENSG00000081377
resolver
ensp
ENSP00000364388
resolver
ensp
ENSP00000364389
resolver
ensp
ENSP00000364390
resolver
ensp
ENSP00000417897
resolver
ensp
ENSP00000420572
resolver
ensp
ENSP00000516645
resolver
ensp
ENSP00000526475
resolver
ensp
ENSP00000526476
resolver
ensp
ENSP00000526477
resolver
ensp
ENSP00000644189
resolver
enst
ENST00000481149
resolver
genesymbol
CDC14B
resolver
hgnc
HGNC:1719
resolver
uniprot
A0A9L9PY50
resolver
uniprot
A6N5X8
resolver
uniprot
A8MQ20
resolver
uniprot
B1AL31
resolver
uniprot
B1AL32
resolver
uniprot
O43183
resolver
uniprot
O60730
resolver
uniprot
Q5JU08
resolver
uniprot_entry
A0A9L9PY50_HUMAN
resolver
uniprot_entry
CC14B_HUMAN
resolver
uniprot_sec
A6N5X8
resolver
uniprot_sec
A8MQ20
resolver
uniprot_sec
B1AL31
resolver
uniprot_sec
B1AL32
resolver
uniprot_sec
O43183
resolver
uniprot_sec
O60730
resolver
uniprot_sec
Q5JU08
resolver
amino_acid_sequence
MKRKSERRSSWAAAPPCSRRCSSTSPGVKKIRSSTQQDPRRRDPQDDVYLDITDRLCFAILYSRPKSASNVHYFSIDNELEYENFYADFGPLNLAMVYRYCCKINKKLKSITMLRKKIVHFTGSDQRKQANAAFLVGCYMVIYLGRTPEEAYRILIFGETSYIPFRDAAYGSCNFYITLLDCFHAVKKAMQYGFLNFNSFNLDEYEHYEKAENGDLNWIIPDRFIAFCGPHSRARLESGYHQHSPETYIQYFKNHNVTTIIRLNKRMYDAKRFTDAGFDHHDLFFADGSTPTDAIVKEFLDICENAEGAIAVHCKAGLGRTGTLIACYIMKHYRMTAAETIAWVRICRPGSVIGPQQQFLVMKQTNLWLEGDYFRQKLKGQENGQHRAAFSKLLSGVDDISINGVENQDQQEPEPYSDDDEINGVTQGDRLRALKSRRQSKTNAIPLTVILQSSVQSCKTSEPNISGSAGITKRTTRSASRKSSVKSLSISRTKTVLR
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Dual-specificity phosphatase involved in DNA damage response. Essential regulator of the G2 DNA damage checkpoint: following DNA damage, translocates to the nucleus and dephosphorylates FZR1/CDH1, a key activator of the anaphase promoting complex/cyclosome (APC/C). Dephosphorylates SIRT2 around early anaphase. Dephosphorylation of FZR1/CDH1 activates the APC/C, leading to the ubiquitination of PLK1, preventing entry into mitosis. Preferentially dephosphorylates proteins modified by proline-directed kinases. {ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:9367992}.
uniprot
proteins
mass_dalton
56802
uniprot
proteins
protein_family
Non-receptor class CDC14 subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
11901424
uniprot
proteins
pubmed
12134069
uniprot
proteins
pubmed
12853468
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
17488717
uniprot
proteins
pubmed
18662541
uniprot
proteins
pubmed
9367992
uniprot
proteins
sequence_length
498
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Following DNA damage, translocates from the nucleolus to the nucleoplasm and interacts with FZR1/CDH1.
uniprot
proteins