Denr
entrez
68184
canonical
uniprot
Q9CQJ6
canonical
ensembl
ENSMUSG00000023106
resolver
ensp
ENSMUSP00000023869
resolver
ensp
ENSMUSP00000228377
resolver
enst
ENSMUST00000023869
resolver
genesymbol
Denr
resolver
uniprot
Q3UXY1
resolver
uniprot_entry
DENR_MOUSE
resolver
uniprot_sec
Q3UXY1
resolver
amino_acid_sequence
MATDISESSGADCKGDTKNSAKLDADYPLRVLYCGVCSLPTEYCEYMPDVAKCRQWLEKNFPNEFAKLTVENSPKQETGITEGQGPVGEEEEKKKQKRGGRGQIKQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASVTGEDEIIIQGDFTDDIIDVIQEKWPEVDDDSIEDLGEVKK
uniprot
proteins
function
FUNCTION: Translation regulator forming a complex with MCTS1 to promote translation reinitiation. Translation reinitiation is the process where the small ribosomal subunit remains attached to the mRNA following termination of translation of a regulatory upstream ORF (uORF), and resume scanning on the same mRNA molecule to initiate translation of a downstream ORF, usually the main ORF (mORF). The MCTS1/DENR complex is pivotal to two linked mechanisms essential for translation reinitiation. Firstly, the dissociation of deacylated tRNAs from post-termination 40S ribosomal complexes during ribosome recycling. Secondly, the recruitment in an EIF2-independent manner of aminoacylated initiator tRNA to P site of 40S ribosomes for a new round of translation. This regulatory mechanism governs the translation of more than 150 genes which translation reinitiation is MCTS1/DENR complex-dependent. {ECO:0000250|UniProtKB:O43583}.
uniprot
proteins
mass_dalton
22166
uniprot
proteins
protein_family
DENR family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
198
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O43583}.
uniprot
proteins