Cyp17a1
entrez
25146
canonical
uniprot
P11715
canonical
ensembl
ENSRNOG00000020035
resolver
ensembl
ENSRNOG00060029516
resolver
ensp
ENSRNOP00000027160
resolver
ensp
ENSRNOP00060042646
resolver
enst
ENSRNOT00000027160
resolver
enst
ENSRNOT00060051262
resolver
genesymbol
Cyp17a1
resolver
genesymbol_syn
Cyp17
resolver
uniprot
A0A0G2JSR8
resolver
uniprot
Q68FY2
resolver
uniprot
Q6LAE5
resolver
uniprot_entry
A0A0G2JSR8_RAT
resolver
uniprot_entry
CP17A_RAT
resolver
uniprot_sec
Q68FY2
resolver
uniprot_sec
Q6LAE5
resolver
activity_regulation
ACTIVITY REGULATION: Regulated predominantly by intracellular cAMP levels. The 17,20-lyase activity is stimulated by cytochrome b5, which acts as an allosteric effector increasing the Vmax of the lyase activity. {ECO:0000250|UniProtKB:P05093}.
uniprot
proteins
amino_acid_sequence
MWELVGLLLLILAYFFWVKSKTPGAKLPRSLPSLPLVGSLPFLPRRGHMHVNFFKLQEKYGPIYSLRLGTTTTVIIGHYQLAREVLIKKGKEFSGRPQMVTQSLLSDQGKGVAFADAGSSWHLHRKLVFSTFSLFKDGQKLEKLICQEAKSLCDMMLAHDKESIDLSTPIFMSVTNIICAICFNISYEKNDPKLTAIKTFTEGIVDATGDRNLVDIFPWLTIFPNKGLEVIKGYAKVRNEVLTGIFEKCREKFDSQSISSLTDILIQAKMNSDNNNSCEGRDPDVFSDRHILATVGDIFGAGIETTTTVLKWILAFLVHNPEVKKKIQKEIDQYVGFSRTPTFNDRSHLLMLEATIREVLRIRPVAPMLIPHKANVDSSIGEFTVPKDTHVVVNLWALHHDENEWDQPDQFMPERFLDPTGSHLITPTQSYLPFGAGPRSCIGEALARQELFVFTALLLQRFDLDVSDDKQLPRLEGDPKVVFLIDPFKVKITVRQAWMDAQAEVST
uniprot
proteins
ec_number
1.14.14.19
uniprot
proteins
ec_number
1.14.14.32
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione. Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). {ECO:0000250|UniProtKB:P05093}.
uniprot
proteins
mass_dalton
57250
uniprot
proteins
pathway_participation
PATHWAY: Steroid hormone biosynthesis. {ECO:0000250|UniProtKB:P05093}.; PATHWAY: Steroid biosynthesis; glucocorticoid biosynthesis. {ECO:0000250|UniProtKB:P05093}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1627653
uniprot
proteins
pubmed
2554289
uniprot
proteins
pubmed
2786990
uniprot
proteins
pubmed
3260774
uniprot
proteins
pubmed
3264499
uniprot
proteins
pubmed
3436956
uniprot
proteins
pubmed
7702752
uniprot
proteins
sequence_length
507
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P05093}. Microsome membrane {ECO:0000250|UniProtKB:P05093}.
uniprot
proteins