Caprin1
entrez
53872
canonical
uniprot
Q60865
canonical
ensembl
ENSMUSG00000027184
resolver
ensp
ENSMUSP00000028607
resolver
ensp
ENSMUSP00000106777
resolver
ensp
ENSMUSP00000187107
resolver
ensp
ENSMUSP00000187109
resolver
ensp
ENSMUSP00000187110
resolver
ensp
ENSMUSP00000187112
resolver
ensp
ENSMUSP00000187115
resolver
ensp
ENSMUSP00000187119
resolver
ensp
ENSMUSP00000187133
resolver
ensp
ENSMUSP00000187134
resolver
ensp
ENSMUSP00000187136
resolver
enst
ENSMUST00000028607
resolver
enst
ENSMUST00000111147
resolver
genesymbol
Caprin1
resolver
genesymbol_syn
Gpiap
resolver
genesymbol_syn
Gpiap1
resolver
genesymbol_syn
Gpip137
resolver
genesymbol_syn
M11s1
resolver
genesymbol_syn
Rng105
resolver
uniprot
Q60758
resolver
uniprot
Q61620
resolver
uniprot
Q6IMN3
resolver
uniprot
Q7TT26
resolver
uniprot_entry
CAPR1_MOUSE
resolver
uniprot_sec
Q60758
resolver
uniprot_sec
Q61620
resolver
uniprot_sec
Q6IMN3
resolver
uniprot_sec
Q7TT26
resolver
activity_regulation
ACTIVITY REGULATION: Ability to mediate liquid-liquid phase separation is regulated by ATP: moderate concentrations of ATP enhance phase separation, whereas high concentrations of ATP lead to inhibition of phase separation. {ECO:0000250|UniProtKB:Q14444}.
uniprot
proteins
amino_acid_sequence
MPSATSHSGSGSKSSGPPPPSGSSGSEAAAGAAAPASQHPATGTGAVQTEAMKQILGVIDKKLRNLEKKKGKLDDYQERMNKGERLNQDQLDAVSKYQEVTNNLEFAKELQRSFMALSQDIQKTIKKTARREQLMREEAEQKRLKTVLELQYVLDKLGDDDVRTDLKQGLSGVPILSEEELSLLDEFYKLVDPERDMSLRLNEQYEHASIHLWDLLEGKEKPVCGTTYKALKEIVERVFQSNYFDSTHNHQNGLCEEEEAASAPTVEDQVAEAEPEPAEEYTEQSEVESTEYVNRQFMAETQFSSGEKEQVDEWTVETVEVVNSLQQQPQAASPSVPEPHSLTPVAQSDPLVRRQRVQDLMAQMQGPYNFIQDSMLDFENQTLDPAIVSAQPMNPTQNMDMPQLVCPQVHSESRLAQSNQVPVQPEATQVPLVSSTSEGYTASQPLYQPSHATEQRPQKEPMDQIQATISLNTDQTTASSSLPAASQPQVFQAGTSKPLHSSGINVNAAPFQSMQTVFNMNAPVPPANEPETLKQQSQYQATYNQSFSSQPHQVEQTELQQDQLQTVVGTYHGSQDQPHQVPGNHQQPPQQNTGFPRSSQPYYNSRGVSRGGSRGARGLMNGYRGPANGFRGGYDGYRPSFSNTPNSGYSQSQFTAPRDYSGYQRDGYQQNFKRGSGQSGPRGAPRGRGGPPRPNRGMPQMNTQQVN
uniprot
proteins
function
FUNCTION: mRNA-binding protein that acts as a regulator of mRNAs transport, translation and/or stability, and which is involved in neurogenesis, synaptic plasticity in neurons and cell proliferation and migration in multiple cell types (PubMed:20516077). Plays an essential role in cytoplasmic stress granule formation (By similarity). Acts as an mRNA regulator by mediating formation of some phase-separated membraneless compartment: undergoes liquid-liquid phase separation upon binding to target mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Undergoes liquid-liquid phase separation following phosphorylation and interaction with FMR1, promoting formation of cytoplasmic ribonucleoprotein granules that concentrate mRNAs with factors that inhibit translation and mediate deadenylation of target mRNAs (By similarity). In these cytoplasmic ribonucleoprotein granules, CAPRIN1 mediates recruitment of CNOT7 deadenylase, leading to mRNA deadenylation and degradation (By similarity). Binds directly and selectively to MYC and CCND2 mRNAs (By similarity). In neuronal cells, directly binds to several mRNAs associated with RNA granules, including BDNF, CAMK2A, CREB1, MAP2, NTRK2 mRNAs, as well as to GRIN1 and KPNB1 mRNAs, but not to rRNAs (By similarity). {ECO:0000250|UniProtKB:Q14444, ECO:0000269|PubMed:20516077}.
uniprot
proteins
mass_dalton
78169
uniprot
proteins
post_translational_modification
PTM: Tyrosine phosphorylation by EPHA4 promotes interaction with FMR1 and liquid-liquid phase separation (LLPS) for the formation of a membraneless compartment that concentrates mRNAs with associated regulatory factors. {ECO:0000250|UniProtKB:Q14444}.; PTM: O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. O-glycosylation by OGT inhibit ability to undergo liquid-liquid phase separation (LLPS). {ECO:0000250|UniProtKB:Q14444}.
uniprot
proteins
protein_family
Caprin family
uniprot
proteins
pubmed
14764709
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17210633
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20516077
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
8786113
uniprot
proteins
sequence_length
707
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000269|PubMed:17210633}. Cytoplasm, cytosol {ECO:0000269|PubMed:14764709, ECO:0000269|PubMed:17210633}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q5M9G3}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q14444}. Note=Mediates formation and localizes to cytoplasmic ribonucleoprotein membraneless compartments (By similarity) (PubMed:17210633). Associated with RNA granules (PubMed:17210633). At the leading edge of migrating fibroblasts, colocalizes with DDX3X (By similarity). {ECO:0000250|UniProtKB:Q14444, ECO:0000269|PubMed:17210633}.
uniprot
proteins