CBR1
entrez
873
canonical
uniprot
P16152
canonical
ensembl
ENSG00000159228
resolver
ensp
ENSP00000290349
resolver
ensp
ENSP00000434613
resolver
genesymbol
CBR1
resolver
genesymbol_syn
CBR
resolver
genesymbol_syn
CRN
resolver
genesymbol_syn
SDR21C1
resolver
hgnc
HGNC:1548
resolver
uniprot
A0A384NL53
resolver
uniprot
B2RBZ7
resolver
uniprot
B4DFK7
resolver
uniprot
Q3LHW8
resolver
uniprot_entry
A0A384NL53_HUMAN
resolver
uniprot_entry
CBR1_HUMAN
resolver
uniprot_sec
B2RBZ7
resolver
uniprot_sec
B4DFK7
resolver
uniprot_sec
Q3LHW8
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by quercetin, rutenin and its derivatives. {ECO:0000269|PubMed:17344335, ECO:0000269|PubMed:18449627}.
uniprot
proteins
amino_acid_sequence
MSSGIHVALVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGIAFKVADPTPFHIQAEVTMKTNFFGTRDVCTELLPLIKPQGRVVNVSSIMSVRALKSCSPELQQKFRSETITEEELVGLMNKFVEDTKKGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACCPGWVRTDMAGPKATKSPEEGAETPVYLALLPPDAEGPHGQFVSEKRVEQW
uniprot
proteins
ec_number
1.1.1.184
uniprot
proteins
ec_number
1.1.1.189
uniprot
proteins
ec_number
1.1.1.196
uniprot
proteins
ec_number
1.1.1.197
uniprot
proteins
ec_number
1.1.1.71
uniprot
proteins
function
FUNCTION: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol (PubMed:15799708, PubMed:17344335, PubMed:17912391, PubMed:18449627, PubMed:18826943, PubMed:1921984, PubMed:7005231). Can convert prostaglandin E to prostaglandin F2-alpha (By similarity). Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione (PubMed:17344335, PubMed:18826943). In addition, participates in the glucocorticoid metabolism by catalyzing the NADPH-dependent cortisol/corticosterone into 20beta-dihydrocortisol (20b-DHF) or 20beta-corticosterone (20b-DHB), which are weak agonists of NR3C1 and NR3C2 in adipose tissue (PubMed:28878267). {ECO:0000250|UniProtKB:Q28960, ECO:0000269|PubMed:15799708, ECO:0000269|PubMed:17344335, ECO:0000269|PubMed:17912391, ECO:0000269|PubMed:18449627, ECO:0000269|PubMed:18826943, ECO:0000269|PubMed:1921984, ECO:0000269|PubMed:28878267, ECO:0000269|PubMed:7005231}.
uniprot
proteins
mass_dalton
30375
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
10830953
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15799708
uniprot
proteins
pubmed
1597188
uniprot
proteins
pubmed
17344335
uniprot
proteins
pubmed
17912391
uniprot
proteins
pubmed
18449627
uniprot
proteins
pubmed
18826943
uniprot
proteins
pubmed
1921984
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2182121
uniprot
proteins
pubmed
28878267
uniprot
proteins
pubmed
3141401
uniprot
proteins
pubmed
7005231
uniprot
proteins
pubmed
8421682
uniprot
proteins
pubmed
9740676
uniprot
proteins
sequence_length
277
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
uniprot
proteins