Prdm12
entrez
381359
canonical
uniprot
A2AJ77
canonical
ensembl
ENSMUSG00000079466
resolver
ensp
ENSMUSP00000109098
resolver
enst
ENSMUST00000113470
resolver
genesymbol
Prdm12
resolver
genesymbol_syn
Gm998
resolver
uniprot_entry
PRD12_MOUSE
resolver
amino_acid_sequence
MMGSVLPAEALVLKTGLKAPGLALAEVITSDILHSFLYGRWRNVLGEQLLEDKSHHASPKTAFTAEVLAQSFSGEVQKLSSLVLPVEVIIAQSSIPGEGLGIFSKTWIKAGTEMGPFTGRVIAPEHVDICKNNNLMWEVFNEDGTVRYFIDASQEDHRSWMTYIKCARNEQEQNLEVVQIGTSIFYKAIEMIPPDQELLVWYGNSHNTFLGIPGVPGLEEEQKKNKHEDFHPADSATGTAGRMRCVICHRGFNSRSNLRSHMRIHTLDKPFVCRFCNRRFSQSSTLRNHVRLHTGERPYKCQVCQSAYSQLAGLRAHQKSARHRPPSTALQAHSPALPAPHAHAPALAAAAAAAAAAHHLPAMVL
uniprot
proteins
function
FUNCTION: Transcriptional regulator necessary for the development of nociceptive neurons, playing a key role in determining the nociceptive lineage from neural crest cell progenitors (PubMed:30917305, PubMed:33789102). Initiates neurogenesis and activates downstream pro-neuronal transcription factors, such as NEUROD1, BRN3A, and ISL1, specifically within nociceptive neurons, while repressing non-nociceptor cell fates (PubMed:30917305). Essential for the proper function of nociceptors in adults, influencing both their excitability and their gene expression, thereby impacting how these neurons respond to various pain stimuli (PubMed:34961757). {ECO:0000269|PubMed:26005867, ECO:0000269|PubMed:30917305, ECO:0000269|PubMed:33789102, ECO:0000269|PubMed:34961757}.
uniprot
proteins
mass_dalton
40303
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
26005867
uniprot
proteins
pubmed
30917305
uniprot
proteins
pubmed
33789102
uniprot
proteins
pubmed
34961757
uniprot
proteins
sequence_length
365
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H4Q4}.
uniprot
proteins