Sgo1
entrez
72415
canonical
uniprot
Q9CXH7
canonical
ensembl
ENSMUSG00000023940
resolver
ensp
ENSMUSP00000024736
resolver
ensp
ENSMUSP00000298953
resolver
genesymbol
Sgo1
resolver
genesymbol_syn
Sgol1
resolver
uniprot
Q3U4K4
resolver
uniprot
Q588H1
resolver
uniprot
Q8BKW2
resolver
uniprot_entry
SGO1_MOUSE
resolver
uniprot_sec
Q3U4K4
resolver
uniprot_sec
Q588H1
resolver
uniprot_sec
Q8BKW2
resolver
amino_acid_sequence
MAKERCQKRSFQDTLEDIKNRMKEKRNKNLAGIGKRKSFIVAPGQVPTNTATLLRYYQDNNRLLVLALENEKSKVREAQDVILQLRKECYYLTCQLYALKEKLTSRQSEETTQNWKGRPSDVVSSIDNTTRDLSGKSLQQIAVEETDCPYQTTEPSPAVTPETQGCDFDSGKVESTDEVLPRTISIRRHLRKDFSNISHSTTLEDCKASPRVAQSLEVKGSRCREVTVTLHRLENVCLWNKDQISLCSRLINPAKITETEVILSSKPEQIESKHKRARKRRAEQRRTKQRCKSKSSLRSKGNKNKDKQGLPPTTLDGGIGSCDAYDFNLKGTVHPTPFRQKMNNGCNKETDSSNSEVSDLECSTSEDESDDLYLPPSKRLRDYRESERAVTRPRSKRGLQYPDGKERKEVLPSTAPTGIPPETQESPRCSLKDVTNILQCPRVKIRKPSLPPKRREDSPAVALTKRRCSTIKSYKEPTLASKLRRGDPFTDLCFLNSPIFKQKRGMRCPKRRTKQTQ
uniprot
proteins
function
FUNCTION: Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Involved in centromeric enrichment of AUKRB in prometaphase. {ECO:0000250|UniProtKB:Q5FBB7, ECO:0000269|PubMed:18084284, ECO:0000269|PubMed:18331714}.
uniprot
proteins
mass_dalton
58966
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1. {ECO:0000250}.; PTM: Phosphorylation by NEK2 is essential for chromosome congression in mitosis and for the proper attachment of spindle microtubule to the kinetochore. Phosphorylated by PLK1 and AUKRB (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Shugoshin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15737064
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18084284
uniprot
proteins
pubmed
18331714
uniprot
proteins
sequence_length
517
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5FBB7}. Chromosome, centromere {ECO:0000250|UniProtKB:Q5FBB7}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q5FBB7}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q5FBB7}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q5FBB7}. Nucleus speckle {ECO:0000250|UniProtKB:Q5FBB7}. Note=Localizes to the inner centromere throughout prophase until metaphase and disappears at anaphase. Centromeric localization requires the presence of BUB1 and the interaction with PPP2R1A. Colocalizes with NEK2 at the kinetochore. Colocalizes with and SS18L1 at the kinetochore. Phosphorylation by AUKRB and the presence of BUB1 are required for localization to the kinetochore. Isoform 1 primarily localizes to kinetochores during G2 phase and mitotic prophase, metaphase, and anaphase and does not appear to be associated with kinetochores during late mitosis. Isoform 3 is found at the centrosome in interphase and at spindle poles in mitosis and its spindle pole localization is PLK1 dependent. Isoform 3 does not localize to kinetochores during any stages of the cell cycle. {ECO:0000250|UniProtKB:Q5FBB7}.
uniprot
proteins