MRNIP
entrez
51149
canonical
uniprot
Q6NTE8
canonical
ensembl
ENSG00000161010
resolver
ensembl
ENSG00000283918
resolver
ensp
ENSP00000292586
resolver
ensp
ENSP00000366130
resolver
genesymbol
MRNIP
resolver
genesymbol_syn
C5orf45
resolver
hgnc
HGNC:30817
resolver
uniprot
B5MD09
resolver
uniprot
E9PAK6
resolver
uniprot
Q7Z3D8
resolver
uniprot
Q9BUC1
resolver
uniprot
Q9UN54
resolver
uniprot_entry
MRNIP_HUMAN
resolver
uniprot_sec
B5MD09
resolver
uniprot_sec
E9PAK6
resolver
uniprot_sec
Q7Z3D8
resolver
uniprot_sec
Q9BUC1
resolver
uniprot_sec
Q9UN54
resolver
amino_acid_sequence
MASLQRSRVLRCCSCRLFQAHQVKKSVKWTCKACGEKQSFLQAYGEGSGADCRRHVQKLNLLQGQVSELPLRSLEETVSASEEENVGHQQAGNVKQQEKSQPSESRWLKYLEKDSQELELEGTGVCFSKQPSSKMEEPGPRFSQDLPRKRKWSRSTVQPPCSRGVQDSGGSEVAWGPQKGQAGLTWKVKQGSSPCLQENSADCSAGELRGPGKELWSPIQQVTATSSKWAQFVLPPRKSSHVDSEQPRSLQRDPRPAGPAQAKQGTPRAQASREGLSRPTAAVQLPRATHPVTSGSERPCGKTSWDARTPWAEGGPLVLEAQNPRPTRLCDLFITGEDFDDDV
uniprot
proteins
function
FUNCTION: Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex (PubMed:27568553). Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair (PubMed:27568553).
uniprot
proteins
mass_dalton
37743
uniprot
proteins
mutagenesis
MUTAGEN 100; /note="S->A: Does not affect nuclear localization. Decreases weakly the association with the MRN complex. Reduces phosphorylation; when associated with A-115 and A-143."; /evidence="ECO:0000269|PubMed:27568553"; MUTAGEN 115; /note="S->A: Reduces nuclear localization and increases DNA damage accumulation. Decreases weakly the association with the MRN complex. Reduces phosphorylation; when associated with A-100 and A-143."; /evidence="ECO:0000269|PubMed:27568553"; MUTAGEN 115; /note="S->D: Does not affect nuclear localization."; /evidence="ECO:0000269|PubMed:27568553"; MUTAGEN 141; /note="R->A: Reduces nuclear localization and increases DNA damage accumulation and does not affect the association with the MRN complex; when associated with 148-A--A-151 and A-154."; /evidence="ECO:0000269|PubMed:27568553"; MUTAGEN 143; /note="S->A: Reduces phosphorylation; when associated with A-100 and A-115."; /evidence="ECO:0000269|PubMed:27568553"; MUTAGEN 148..151; /note="RKRK->AAAA: Decreases nuclear localization. Reduces nuclear localization and increases DNA damage accumulation and does not affect the association with the MRN complex; when associated with A-141 and A-154."; /evidence="ECO:0000269|PubMed:27568553"; MUTAGEN 154; /note="R->A: Reduces nuclear localization and increases DNA damage accumulation and does not affect the association with the MRN complex; when associated with A-141 and 148-A--A-151."; /evidence="ECO:0000269|PubMed:27568553"; MUTAGEN 213..237; /note="Missing: Reduces the association with the MRN complex."; /evidence="ECO:0000269|PubMed:27568553
uniprot
proteins
post_translational_modification
PTM: Phosphorylated; phosphorylation is constitutive and occurs in the absence of any DNA-damaging stimulus. Phosphorylation on Ser-115 is necessary for its nuclear retention. {ECO:0000269|PubMed:27568553}.
uniprot
proteins
protein_family
MRNIP family
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
27568553
uniprot
proteins
sequence_length
343
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27568553}. Nucleus, nucleoplasm {ECO:0000269|PubMed:27568553}. Note=Recruited to sites of DNA damage (PubMed:27568553). Phosphorylation on Ser-115 induces its nuclear localization and promotes genome stability (PubMed:27568553). {ECO:0000269|PubMed:27568553}.
uniprot
proteins