TNFRSF4
entrez
7293
canonical
uniprot
P43489
canonical
ensembl
ENSG00000186827
resolver
ensp
ENSP00000368538
resolver
ensp
ENSP00000514730
resolver
enst
ENST00000379236
resolver
enst
ENST00000699974
resolver
genesymbol
TNFRSF4
resolver
genesymbol_syn
TXGP1L
resolver
hgnc
HGNC:11918
resolver
uniprot
A0A8V8TQH5
resolver
uniprot
Q13663
resolver
uniprot
Q2M312
resolver
uniprot
Q5T7M0
resolver
uniprot_entry
A0A8V8TQH5_HUMAN
resolver
uniprot_entry
TNR4_HUMAN
resolver
uniprot_sec
Q13663
resolver
uniprot_sec
Q2M312
resolver
uniprot_sec
Q5T7M0
resolver
amino_acid_sequence
MCVGARRLGRGPCAALLLLGLGLSTVTGLHCVGDTYPSNDRCCHECRPGNGMVSRCSRSQNTVCRPCGPGFYNDVVSSKPCKPCTWCNLRSGSERKQLCTATQDTVCRCRAGTQPLDSYKPGVDCAPCPPGHFSPGDNQACKPWTNCTLAGKHTLQPASNSSDAICEDRDPPATQPQETQGPPARPITVQPTEAWPRTSQGPSTRPVEVPGGRAVAAILGLGLVLGLLGPLAILLALYLLRRDQRLPPDAHKPPGGGSFRTPIQEEQADAHSTLAKI
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency 16 (IMD16) [MIM:615593]: An autosomal recessive primary immunodeficiency associated with classic Kaposi sarcoma of childhood and poor T-cell recall immune responses due to complete functional OX40 deficiency. {ECO:0000269|PubMed:23897980}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity. {ECO:0000269|PubMed:7704935}.; FUNCTION: (Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B. {ECO:0000269|PubMed:23674671}.
uniprot
proteins
mass_dalton
29341
uniprot
proteins
pubmed
10861060
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16905106
uniprot
proteins
pubmed
23674671
uniprot
proteins
pubmed
23897980
uniprot
proteins
pubmed
7510240
uniprot
proteins
pubmed
7704935
uniprot
proteins
pubmed
9418902
uniprot
proteins
pubmed
9488716
uniprot
proteins
sequence_length
277
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 215..235; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins