DNTT
entrez
1791
canonical
uniprot
P04053
canonical
ensembl
ENSG00000107447
resolver
ensp
ENSP00000360216
resolver
ensp
ENSP00000486733
resolver
genesymbol
DNTT
resolver
genesymbol_syn
TDT
resolver
hgnc
HGNC:2983
resolver
uniprot
Q53FH1
resolver
uniprot
Q5W103
resolver
uniprot
Q96E50
resolver
uniprot_entry
TDT_HUMAN
resolver
uniprot_sec
Q53FH1
resolver
uniprot_sec
Q5W103
resolver
uniprot_sec
Q96E50
resolver
amino_acid_sequence
MDPPRASHLSPRKKRPRQTGALMASSPQDIKFQDLVVFILEKKMGTTRRAFLMELARRKGFRVENELSDSVTHIVAENNSGSDVLEWLQAQKVQVSSQPELLDVSWLIECIRAGKPVEMTGKHQLVVRRDYSDSTNPGPPKTPPIAVQKISQYACQRRTTLNNCNQIFTDAFDILAENCEFRENEDSCVTFMRAASVLKSLPFTIISMKDTEGIPCLGSKVKGIIEEIIEDGESSEVKAVLNDERYQSFKLFTSVFGVGLKTSEKWFRMGFRTLSKVRSDKSLKFTRMQKAGFLYYEDLVSCVTRAEAEAVSVLVKEAVWAFLPDAFVTMTGGFRRGKKMGHDVDFLITSPGSTEDEEQLLQKVMNLWEKKGLLLYYDLVESTFEKLRLPSRKVDALDHFQKCFLIFKLPRQRVDSDQSSWQEGKTWKAIRVDLVLCPYERRAFALLGWTGSRQFERDLRRYATHERKMILDNHALYDKTKRIFLKAESEEEIFAHLGLDYIEPWERNA
uniprot
proteins
ec_number
2.7.7.31
uniprot
proteins
function
FUNCTION: Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells. {ECO:0000250|UniProtKB:P09838}.
uniprot
proteins
mass_dalton
58536
uniprot
proteins
mutagenesis
MUTAGEN 343; /note="D->E: Nearly abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:8163485
uniprot
proteins
protein_family
DNA polymerase type-X family
uniprot
proteins
pubmed
11473582
uniprot
proteins
pubmed
11554927
uniprot
proteins
pubmed
12786946
uniprot
proteins
pubmed
12960389
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16371131
uniprot
proteins
pubmed
2833741
uniprot
proteins
pubmed
2863268
uniprot
proteins
pubmed
3395350
uniprot
proteins
pubmed
6087320
uniprot
proteins
pubmed
8163485
uniprot
proteins
sequence_length
509
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16371131}.
uniprot
proteins