Rpgr
entrez
19893
canonical
uniprot
Q9R0X5
canonical
ensembl
ENSMUSG00000031174
resolver
ensp
ENSMUSP00000037358
resolver
ensp
ENSMUSP00000073106
resolver
ensp
ENSMUSP00000111194
resolver
ensp
ENSMUSP00000111195
resolver
ensp
ENSMUSP00000111196
resolver
enst
ENSMUST00000044598
resolver
enst
ENSMUST00000073392
resolver
enst
ENSMUST00000115532
resolver
enst
ENSMUST00000115533
resolver
enst
ENSMUST00000115534
resolver
genesymbol
Rpgr
resolver
genesymbol_syn
Srpx
resolver
uniprot
A0A067XG46
resolver
uniprot
A2ADP2
resolver
uniprot
A2ADP3
resolver
uniprot
F6XSE8
resolver
uniprot
F6XSF9
resolver
uniprot
F6XSH1
resolver
uniprot
G9BBQ2
resolver
uniprot
O88408
resolver
uniprot
Q3UTY5
resolver
uniprot
Q8CAJ5
resolver
uniprot
Q8CDM3
resolver
uniprot
Q9CU92
resolver
uniprot_entry
A0A067XG46_MOUSE
resolver
uniprot_entry
A2ADP2_MOUSE
resolver
uniprot_entry
F6XSE8_MOUSE
resolver
uniprot_entry
F6XSF9_MOUSE
resolver
uniprot_entry
F6XSH1_MOUSE
resolver
uniprot_entry
Q3UTY5_MOUSE
resolver
uniprot_entry
Q8CAJ5_MOUSE
resolver
uniprot_entry
Q8CDM3_MOUSE
resolver
uniprot_entry
RPGR_MOUSE
resolver
uniprot_sec
A2ADP3
resolver
uniprot_sec
G9BBQ2
resolver
uniprot_sec
O88408
resolver
uniprot_sec
Q9CU92
resolver
amino_acid_sequence
MAESESLVPDTGAVFTFGKTKFAENIPSKFWFKNDIPICLSCGDEHTAIVTGNNKLYMFGSNNWGQLGLGSKAAIIKPTCIKALKPEKVKLAACGRNHTLVSTDTGGVYAAGGNNEGQLGLGDTDDRDTFHQIVFFTPADTIKQLSAGANTSAALTEDGKLFMWGDNSEGQIGLEDKSNVCIPHEVTVGKPISWISCGYYHSAFVTMDGELYTFGEPENGKLGLPNELLMNHRSPQRVLGIPERVIQVACGGGHTVVLTEKVVYAFGLGQFGQLGLGTFLFETSEPKIIERIKDQKICHISCGENHTALMTELGLLYTFGDGRHGKLGLGMENFTNQFFPTLCSNFLRFAVQLIACGGCHMLVFATPRLGTIDEPKFEDVYEPYISTGSFSINDLSPRSSLNRSLSARLRRRERERPPCSASMVGTLPPLEGTSASTSAYFYPSSPPFHLSVNNYPEKSPSESMEPLDSDYFEDKMNKDTETENSSAVDSENFGETNDILNMTHMMTTSSNEKLLDFSPIQKQQNQDTFEKVMESTPCTENEDSYEYEEMSKIKEVTVYKQYLAKGIYMIRPAEILEAFSDEEVGNGLDQVEEPRVFTDGKGLQSKQVGKESDEEIVSEKKTEVMEVADVKKIRESEENSKSDSLFDDLPDKTMNSESEDNKDIAEERRSSEQNMTFDSETELVEEPDSYMECERHSEQDSAEELEQPKLVEYSSEEKDEKDEKDDDEVETENLWYDRNCTEQETENVFRATRFFPKFDLKHDHLSGIPEEQEGPEDSEGNVVVEQVVQAQKENLEFEGDRKEAKAEAPSDVITEKEAPQLSETVKPEEGEMDEEISILNVEDTVEEERKEGEKEIVEEGSIPETEGSETIDITDEKLDEVLKEEDSASLLQRALREYNENPKGHMYDRVKSSSSEILGGNDPTSKDIKKAKKISFFNRMSLTGQKLMQNTNDPLPEIKPIGDQIALQSDKKDANQNHMGQNLQDSTTPNMEGKSKSCTIL
uniprot
proteins
function
FUNCTION: Acts as a guanine-nucleotide releasing factor (GEF) for RAB8A and RAB37 by promoting the conversion of inactive RAB-GDP to the active form RAB-GTP (PubMed:38536817). GEF activity towards RAB8A may facilitate ciliary trafficking by modulating ciliary intracellular localization of RAB8A (By similarity). GEF activity towards RAB37 maintains autophagic homeostasis and retinal function (PubMed:38536817). Involved in photoreceptor integrity (PubMed:22563472, PubMed:38536817). May control cilia formation by regulating actin stress filaments and cell contractility. May be involved in microtubule organization and regulation of transport in primary cilia (By similarity). {ECO:0000250|UniProtKB:Q92834, ECO:0000269|PubMed:22563472, ECO:0000269|PubMed:38536817}.; FUNCTION: [Isoform 5]: Isoform 5 may play a critical role in spermatogenesis and in intraflagellar transport processes. {ECO:0000269|PubMed:18579752}.
uniprot
proteins
mass_dalton
111801
uniprot
proteins
post_translational_modification
PTM: Prenylated. {ECO:0000269|PubMed:9677393}.
uniprot
proteins
pubmed
10401007
uniprot
proteins
pubmed
11702207
uniprot
proteins
pubmed
12140192
uniprot
proteins
pubmed
15772089
uniprot
proteins
pubmed
16043481
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16632484
uniprot
proteins
pubmed
18579752
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20007830
uniprot
proteins
pubmed
20805823
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21546531
uniprot
proteins
pubmed
22323458
uniprot
proteins
pubmed
22563472
uniprot
proteins
pubmed
29899041
uniprot
proteins
pubmed
38536817
uniprot
proteins
pubmed
9677393
uniprot
proteins
pubmed
9990021
uniprot
proteins
sequence_length
1001
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:15772089, ECO:0000269|PubMed:16043481, ECO:0000269|PubMed:20007830, ECO:0000269|PubMed:9677393}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q92834}. Cell projection, cilium {ECO:0000269|PubMed:29899041, ECO:0000269|PubMed:38536817}. Note=In the retinal photoreceptor cell layer, localizes at the connecting cilium (PubMed:29899041, PubMed:38536817). Colocalizes with WHRN in the photoreceptor connecting cilium (PubMed:22323458). Colocalizes with CEP290 in the photoreceptor connecting cilium (PubMed:16632484). Colocalizes with RPGRIP1 in the photoreceptor connecting cilium (PubMed:15772089). Colocalizes with RPGR at the primary cilia of epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q9N1T2, ECO:0000269|PubMed:15772089, ECO:0000269|PubMed:16632484, ECO:0000269|PubMed:22323458, ECO:0000269|PubMed:29899041, ECO:0000269|PubMed:38536817}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, cilium axoneme. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:20007830}.
uniprot
proteins