St6galnac5
entrez
26938
canonical
uniprot
Q9QYJ1
canonical
ensembl
ENSMUSG00000039037
resolver
ensp
ENSMUSP00000036227
resolver
enst
ENSMUST00000044278
resolver
genesymbol
St6galnac5
resolver
genesymbol_syn
Siat7e
resolver
uniprot
F6XXM4
resolver
uniprot
Q6GTI0
resolver
uniprot
Q9R0K6
resolver
uniprot_entry
F6XXM4_MOUSE
resolver
uniprot_entry
Q6GTI0_MOUSE
resolver
uniprot_entry
SIA7E_MOUSE
resolver
uniprot_sec
Q9R0K6
resolver
amino_acid_sequence
MKTLMRHGLAVCLVLTTMCTSLLLVYSSLGSQKERPPQQQQQQQQQQQQAATATGSTQLVESSPQPRRTAPAGPRQLEGYLGVADHKPLKMHCKDCALVTSSGHLLRSQQGPHIDQTECVIRMNDAPTRGYGLDVGNRTSLRVIAHSSIQRILRNRHDLLNVSQGTVFIFWGPSSYMRRDGKGQAYNNLQLLSQVLPRLKAFMITRHRMLQFDELFKQETGKDRKISNTWLSTGWFTMTIALELCDRIDVYGMVPPDFCRDPKHPSVPYHYYEPSGPDECTMYLSHERGRKGSHHRFITEKRVFKNWARTFNIHFFQPDWKPESPAVNHAEGKPVF
uniprot
proteins
ec_number
2.4.99.-
uniprot
proteins
function
FUNCTION: Predominantly catalyzes the biosynthesis of ganglioside GD1alpha from GM1b in the brain, by transferring the sialyl group (N-acetyl-alpha-neuraminyl or NeuAc) from CMP-NeuAc to the GalNAc residue on the NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc sequence of GM1b (PubMed:10521438, PubMed:10601645). GD1alpha is a critical molecule in the communication and interaction between neuronal cells and their supportive cells, particularly in brain tissues, and functions as an adhesion molecule in the process of metastasis (PubMed:9157980). Also shows activity towards sialyl Lc4Cer (N-acetyl-alpha-neuraminosyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acyl-sphing-4-enine) generating disialyl Lc4Cer, which can lead to the synthesis of disialyl Lewis a (Le(a)), suggested to be a cancer-associated antigen (By similarity). {ECO:0000250|UniProtKB:Q9BVH7, ECO:0000269|PubMed:10521438, ECO:0000269|PubMed:10601645, ECO:0000269|PubMed:9157980}.
uniprot
proteins
mass_dalton
38430
uniprot
proteins
pathway_participation
PATHWAY: Glycolipid biosynthesis. {ECO:0000305|PubMed:10521438, ECO:0000305|PubMed:10601645}.
uniprot
proteins
protein_family
Glycosyltransferase 29 family
uniprot
proteins
pubmed
10521438
uniprot
proteins
pubmed
10601645
uniprot
proteins
pubmed
9157980
uniprot
proteins
sequence_length
336
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane; Single-pass type II membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins