ABCC2
entrez
1244
canonical
uniprot
Q92887
canonical
ensembl
ENSG00000023839
resolver
ensp
ENSP00000497274
resolver
enst
ENST00000647814
resolver
genesymbol
ABCC2
resolver
genesymbol_syn
CMOAT
resolver
genesymbol_syn
CMOAT1
resolver
genesymbol_syn
CMRP
resolver
genesymbol_syn
MRP2
resolver
hgnc
HGNC:53
resolver
uniprot
B2RMT8
resolver
uniprot
Q14022
resolver
uniprot
Q5T2B1
resolver
uniprot
Q92500
resolver
uniprot
Q92798
resolver
uniprot
Q99663
resolver
uniprot
Q9UMS2
resolver
uniprot_entry
MRP2_HUMAN
resolver
uniprot_sec
B2RMT8
resolver
uniprot_sec
Q14022
resolver
uniprot_sec
Q5T2B1
resolver
uniprot_sec
Q92500
resolver
uniprot_sec
Q92798
resolver
uniprot_sec
Q99663
resolver
uniprot_sec
Q9UMS2
resolver
amino_acid_sequence
MLEKFCNSTFWNSSFLDSPEADLPLCFEQTVLVWIPLGYLWLLAPWQLLHVYKSRTKRSSTTKLYLAKQVFVGFLLILAAIELALVLTEDSGQATVPAVRYTNPSLYLGTWLLVLLIQYSRQWCVQKNSWFLSLFWILSILCGTFQFQTLIRTLLQGDNSNLAYSCLFFISYGFQILILIFSAFSENNESSNNPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVSKFETHMKRELQKARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMKALFKTFYMVLLKSFLLKLVNDIFTFVSPQLLKLLISFASDRDTYLWIGYLCAILLFTAALIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMISSMLQASVSTERLEKYLGGDDLDTSAIRHDCNFDKAMQFSEASFTWEHDSEATVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTAYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRSSRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIGLFSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFMAKEAGIENVNSTKF
uniprot
proteins
disease_involvement
DISEASE: Dubin-Johnson syndrome (DJS) [MIM:237500]: Autosomal recessive disorder characterized by conjugated hyperbilirubinemia, an increase in the urinary excretion of coproporphyrin isomer I, deposition of melanin-like pigment in hepatocytes, and prolonged retention of sulfobromophthalein, but otherwise normal liver function. {ECO:0000269|PubMed:10053008, ECO:0000269|PubMed:10464142, ECO:0000269|PubMed:11093739, ECO:0000269|PubMed:11266082, ECO:0000269|PubMed:11477083, ECO:0000269|PubMed:22290738, ECO:0000269|PubMed:25336012, ECO:0000269|PubMed:9425227}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
7.6.2.-
uniprot
proteins
ec_number
7.6.2.2
uniprot
proteins
ec_number
7.6.2.3
uniprot
proteins
function
FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyzes ATP to enable active transport of substrates conjugated with glucuronate, glutathione or sulfate. Operates at apical membranes of polarized cells such as hepatocytes, renal and intestinal epithelial cells where it mediates hepatobiliary and renal excretion of conjugated substrates (PubMed:10220572, PubMed:10421658, PubMed:11500505, PubMed:16332456, PubMed:29175180, PubMed:30959153, PubMed:31704245). Involved in canalicular bile production. Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin, enabling bilirubin detoxification (PubMed:9355767, PubMed:10421658). Mediates the efflux of steroid glucuronates from intestine and liver into the intestinal lumen. Shares substrate specificity with MRP3 but displays lower affinity and higher transport velocity toward androgen conjugates such as testosterone and dihydrotestosterone glucuronates as well as toward estrogen conjugates including estradiol, estrone and estriol glucuronates (PubMed:29175180, PubMed:30959153, PubMed:31704245). Transports glutathione conjugate leukotriene C4 (LTC4) and related cysteinyl leukotrienes (PubMed:11500505). Displays selective transporter activity toward sulfated conjugates, transports sulfated bile salts such as taurolithocholate sulfate but is inactive toward androgen sulfates (PubMed:16332456, PubMed:39993711). Transports various xenobiotics including anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors. Confers resistance to several anticancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine, by decreasing accumulation of these drugs in cells (PubMed:10220572, PubMed:11500505, PubMed:12441801). {ECO:0000269|PubMed:10220572, ECO:0000269|PubMed:10421658, ECO:0000269|PubMed:11500505, ECO:0000269|PubMed:12441801, ECO:0000269|PubMed:16332456, ECO:0000269|PubMed:29175180, ECO:0000269|PubMed:30959153, ECO:0000269|PubMed:31704245, ECO:0000269|PubMed:39993711, ECO:0000269|PubMed:9355767}.
uniprot
proteins
mass_dalton
174207
uniprot
proteins
mutagenesis
MUTAGEN 1254; /note="W->A,C: Fails to transport methotrexate, leukotriene C4 and estradiol glucuronide."; /evidence="ECO:0000269|PubMed:11500505"; MUTAGEN 1254; /note="W->F: Fails to transport methotrexate and leukotriene C4. Does not affect estradiol glucuronide transport."; /evidence="ECO:0000269|PubMed:11500505"; MUTAGEN 1254; /note="W->Y: Fails to transport methotrexate; reduces leukotriene C4 transport. Does not affect estradiol glucuronide transport."; /evidence="ECO:0000269|PubMed:11500505
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCC family
uniprot
proteins
protein_family
Conjugate transporter (TC 3.A.1.208) subfamily
uniprot
proteins
pubmed
10053008
uniprot
proteins
pubmed
10220572
uniprot
proteins
pubmed
10421658
uniprot
proteins
pubmed
10464142
uniprot
proteins
pubmed
11093739
uniprot
proteins
pubmed
11266082
uniprot
proteins
pubmed
11477083
uniprot
proteins
pubmed
11500505
uniprot
proteins
pubmed
12441801
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16332456
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22290738
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25336012
uniprot
proteins
pubmed
28408210
uniprot
proteins
pubmed
29175180
uniprot
proteins
pubmed
30959153
uniprot
proteins
pubmed
31704245
uniprot
proteins
pubmed
39993711
uniprot
proteins
pubmed
8662992
uniprot
proteins
pubmed
8797578
uniprot
proteins
pubmed
9355767
uniprot
proteins
pubmed
9425227
uniprot
proteins
sequence_length
1545
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:10220572, ECO:0000269|PubMed:11093739, ECO:0000269|PubMed:28408210}; Multi-pass membrane protein {ECO:0000255}. Note=Localized to the apical membrane of enterocytes. {ECO:0000269|PubMed:28408210}.
uniprot
proteins
transmembrane_region
TRANSMEM 28..48; /note="Helical; Name=1"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 69..89; /note="Helical; Name=2"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 94..114; /note="Helical; Name=3"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 127..147; /note="Helical; Name=4"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 166..186; /note="Helical; Name=5"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 314..334; /note="Helical; Name=6"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 361..381; /note="Helical; Name=7"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 438..458; /note="Helical; Name=8"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 462..482; /note="Helical; Name=9"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 545..565; /note="Helical; Name=10"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 588..608; /note="Helical; Name=11"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 972..992; /note="Helical; Name=12"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1034..1054; /note="Helical; Name=13"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1098..1118; /note="Helical; Name=14"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1120..1140; /note="Helical; Name=15"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1212..1232; /note="Helical; Name=16"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1235..1255; /note="Helical; Name=17"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441
uniprot
proteins