Hrg
entrez
94175
canonical
uniprot
Q9ESB3
canonical
ensembl
ENSMUSG00000022877
resolver
ensp
ENSMUSP00000023590
resolver
enst
ENSMUST00000023590
resolver
genesymbol
Hrg
resolver
uniprot
A0A0R4J039
resolver
uniprot
Q6YK32
resolver
uniprot
Q6YKA2
resolver
uniprot
Q99PS5
resolver
uniprot
Q99PS6
resolver
uniprot_entry
A0A0R4J039_MOUSE
resolver
uniprot_entry
HRG_MOUSE
resolver
uniprot_sec
Q6YK32
resolver
uniprot_sec
Q6YKA2
resolver
uniprot_sec
Q99PS5
resolver
uniprot_sec
Q99PS6
resolver
amino_acid_sequence
MKVLTTALLLVTLQCSHALSPTNCDASEPLAEKVLDLINKGRRSGYVFELLRVSDAHLDRAGTATVYYLALDVIESDCWVLSTKAQDDCLPSRWQSEIVIGQCKVIATRYSNESQDLSVNGYNCTTSSVSSALRNTKDSPVLLDFFEDSELYRKQARKALDKYKTDNGDFASFRVERAERVIRARGGERTNYYVEFSMRNCSTQHFPRSPLVFGFCRALLSYSIETSDLETPDSIDINCEVFNIEDHKDTSDMKPHWGHERPLCDKHLCKLSGSRDHHHTHKTDKLGCPPPPEGKDNSDRPRLQEGALPQLPPGYPPHSGANRTHRPSYNHSCNEHPCHGHRPHGHHPHSHHPPGHHSHGHHPHGHHPHSHHSHGHHPPGHHPHGHHPHGHHPHGHHPHGHHPHGHDFLDYGPCDPPSNSQELKGQYHRGYGPPHGHSRKRGPGKGLFPFHHQQIGYVYRLPPLNIGEVLTLPEANFPSFSLPNCNRSLQPEIQPFPQTASRSCPGKFESEFPQISKFFGYTPPK
uniprot
proteins
function
FUNCTION: Plasma glycoprotein that binds a number of ligands such as heme, heparin, heparan sulfate, thrombospondin, plasminogen, and divalent metal ions. Binds heparin and heparin/glycosaminoglycans in a zinc-dependent manner. Binds heparan sulfate on the surface of liver, lung, kidney and heart endothelial cells. Binds to N-sulfated polysaccharide chains on the surface of liver endothelial cells. Inhibits rosette formation. Acts as an adapter protein and is implicated in regulating many processes such as immune complex and pathogen clearance, cell chemotaxis, cell adhesion, angiogenesis, coagulation and fibrinolysis. Mediates clearance of necrotic cells through enhancing the phagocytosis of necrotic cells in a heparan sulfate-dependent pathway. This process can be regulated by the presence of certain HRG ligands such as heparin and zinc ions. Binds to IgG subclasses of immunoglobins containing kappa and lambda light chains with different affinities regulating their clearance and inhibiting the formation of insoluble immune complexes. Tethers plasminogen to the cell surface. Binds T-cells and alters the cell morphology. Acts as a regulator of the vascular endothelial growth factor (VEGF) signaling pathway; inhibits endothelial cell motility by reducing VEGF-induced complex formation between PXN/paxillin and ILK/integrin-linked protein kinase and by promoting inhibition of VEGF-induced tyrosine phosphorylation of focal adhesion kinases and alpha-actinins in endothelial cells. Also plays a role in the regulation of tumor angiogenesis and tumor immune surveillance. Normalizes tumor vessels and promotes antitumor immunity by polarizing tumor-associated macrophages, leading to decreased tumor growth and metastasis (By similarity). Modulates angiogenesis by blocking the CD6-mediated antiangiongenic effect of thrombospondins, THBS1 and THBS2. {ECO:0000250, ECO:0000269|PubMed:15748999, ECO:0000269|PubMed:15869579, ECO:0000269|PubMed:18797515, ECO:0000269|PubMed:19903770, ECO:0000269|PubMed:22374984}.
uniprot
proteins
mass_dalton
59163
uniprot
proteins
post_translational_modification
PTM: Proteolytic cleavage produces several HRG fragments which are mostly disulfide-linked and, therefore, not released. Cleavage by plasmin is inhibited in the presence of heparin, zinc ions or in an acidic environment. Cleavage reduces binding of HRG to heparan sulfate, but enhances the ability of HRG to bind and tether plasminogen to the cell surface. On platelet activation, releases a 33 kDa antiangiogenic peptide which encompasses the HRR. Also cleaved in the C-terminal by plasmin (By similarity). {ECO:0000250}.; PTM: N-glycosylated. {ECO:0000269|PubMed:17330941}.
uniprot
proteins
pubmed
10849117
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15499407
uniprot
proteins
pubmed
15748999
uniprot
proteins
pubmed
15869579
uniprot
proteins
pubmed
17330941
uniprot
proteins
pubmed
18797515
uniprot
proteins
pubmed
19903770
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21264222
uniprot
proteins
pubmed
22374984
uniprot
proteins
sequence_length
525
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins