SEH1L
entrez
81929
canonical
uniprot
Q96EE3
canonical
ensembl
ENSG00000085415
resolver
ensp
ENSP00000262124
resolver
ensp
ENSP00000382779
resolver
ensp
ENSP00000577015
resolver
ensp
ENSP00000665250
resolver
genesymbol
SEH1L
resolver
genesymbol_syn
SEC13L
resolver
genesymbol_syn
SEH1
resolver
hgnc
HGNC:30379
resolver
uniprot
A8K5B1
resolver
uniprot
Q8NFU6
resolver
uniprot
Q96MH3
resolver
uniprot
Q9C069
resolver
uniprot_entry
SEH1_HUMAN
resolver
uniprot_sec
A8K5B1
resolver
uniprot_sec
Q8NFU6
resolver
uniprot_sec
Q96MH3
resolver
uniprot_sec
Q9C069
resolver
activity_regulation
ACTIVITY REGULATION: The GATOR2 complex is negatively regulated by the upstream amino acid sensors CASTOR1 and SESN2, which sequester the GATOR2 complex in absence of amino acids (PubMed:25457612, PubMed:26972053, PubMed:27487210, PubMed:35831510). In the presence of abundant amino acids, GATOR2 is released from CASTOR1 and SESN2 and activated (PubMed:25457612, PubMed:26972053, PubMed:27487210, PubMed:35831510). {ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:26972053, ECO:0000269|PubMed:27487210, ECO:0000269|PubMed:35831510}.
uniprot
proteins
amino_acid_sequence
MFVARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDWHCTASWKTHSGSVWRVTWAHPEFGQVLASCSFDRTAAVWEEIVGESNDKLRGQSHWVKRTTLVDSRTSVTDVKFAPKHMGLMLATCSADGIVRIYEAPDVMNLSQWSLQHEISCKLSCSCISWNPSSSRAHSPMIAVGSDDSSPNAMAKVQIFEYNENTRKYAKAETLMTVTDPVHDIAFAPNLGRSFHILAIATKDVRIFTLKPVRKELTSSGGPTKFEIHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKANYMDNWKCTGILKGNGSPVNGSSQQGTSNPSLGSTIPSLQNSLNGSSAGRKHS
uniprot
proteins
function
FUNCTION: Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC (PubMed:15146057, PubMed:17363900). The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore (PubMed:15146057, PubMed:17363900). {ECO:0000269|PubMed:15146057, ECO:0000269|PubMed:17363900}.; FUNCTION: As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:23723238, PubMed:25457612, PubMed:27487210, PubMed:35831510, PubMed:36528027). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (PubMed:23723238, PubMed:27487210, PubMed:35831510, PubMed:36528027). GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 (PubMed:36528027). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (PubMed:36528027). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (PubMed:25457612, PubMed:26972053, PubMed:27487210). Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex (PubMed:35831510). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:26972053, ECO:0000269|PubMed:27487210, ECO:0000269|PubMed:35831510, ECO:0000269|PubMed:36528027}.
uniprot
proteins
mass_dalton
39649
uniprot
proteins
protein_family
WD repeat SEC13 family
uniprot
proteins
pubmed
12196509
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15146057
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17360435
uniprot
proteins
pubmed
17363900
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23723238
uniprot
proteins
pubmed
25263562
uniprot
proteins
pubmed
25457612
uniprot
proteins
pubmed
26972053
uniprot
proteins
pubmed
27487210
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28199306
uniprot
proteins
pubmed
35831510
uniprot
proteins
pubmed
36528027
uniprot
proteins
sequence_length
360
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore {ECO:0000269|PubMed:15146057, ECO:0000269|PubMed:17363900}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:15146057, ECO:0000269|PubMed:17363900}. Lysosome membrane {ECO:0000269|PubMed:28199306}.
uniprot
proteins