COPS5
entrez
10987
canonical
uniprot
Q92905
canonical
ensembl
ENSG00000121022
resolver
ensp
ENSP00000350512
resolver
enst
ENST00000357849
resolver
genesymbol
COPS5
resolver
genesymbol_syn
CSN5
resolver
genesymbol_syn
JAB1
resolver
hgnc
HGNC:2240
resolver
uniprot
A0A024R7W9
resolver
uniprot
O15386
resolver
uniprot
Q6AW95
resolver
uniprot
Q86WQ4
resolver
uniprot
Q9BQ17
resolver
uniprot_entry
A0A024R7W9_HUMAN
resolver
uniprot_entry
CSN5_HUMAN
resolver
uniprot_sec
O15386
resolver
uniprot_sec
Q6AW95
resolver
uniprot_sec
Q86WQ4
resolver
uniprot_sec
Q9BQ17
resolver
amino_acid_sequence
MAASGSGMAQKTWELANNMQEAQSIDEIYKYDKKQQQEILAAKPWTKDHHYFKYCKISALALLKMVMHARSGGNLEVMGLMLGKVDGETMIIMDSFALPVEGTETRVNAQAAAYEYMAAYIENAKQVGRLENAIGWYHSHPGYGCWLSGIDVSTQMLNQQFQEPFVAVVIDPTRTISAGKVNLGAFRTYPKGYKPPDEGPSEYQTIPLNKIEDFGVHCKQYYALEVSYFKSSLDRKLLELLWNKYWVNTLSSSSLLTNADYTTGQVFDLSEKLEQSEAQLGRGSFMLGLETHDRKSEDKLAKATRDSCKTTIEAIHGLMSQVIKDKLFNQINIS
uniprot
proteins
ec_number
3.4.-.-
uniprot
proteins
function
FUNCTION: Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex. Interacts directly with a large number of proteins that are regulated by the CSN complex, confirming a key role in the complex. Promotes the proteasomal degradation of BRSK2. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:19214193, ECO:0000269|PubMed:20978819, ECO:0000269|PubMed:22609399, ECO:0000269|PubMed:9535219}.
uniprot
proteins
mass_dalton
37579
uniprot
proteins
mutagenesis
MUTAGEN 138; /note="H->Q: Abolishes ability to deneddylate cullins, without affecting the 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex."; /evidence="ECO:0000269|PubMed:19214193
uniprot
proteins
protein_family
CSN5 subfamily
uniprot
proteins
protein_family
Peptidase M67A family
uniprot
proteins
pubmed
10362352
uniprot
proteins
pubmed
10722692
uniprot
proteins
pubmed
10766246
uniprot
proteins
pubmed
11089976
uniprot
proteins
pubmed
11285227
uniprot
proteins
pubmed
11337588
uniprot
proteins
pubmed
11709497
uniprot
proteins
pubmed
11818334
uniprot
proteins
pubmed
12082530
uniprot
proteins
pubmed
12628923
uniprot
proteins
pubmed
12732143
uniprot
proteins
pubmed
14500717
uniprot
proteins
pubmed
14993265
uniprot
proteins
pubmed
15126503
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16300740
uniprot
proteins
pubmed
17050680
uniprot
proteins
pubmed
17123647
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18850735
uniprot
proteins
pubmed
19214193
uniprot
proteins
pubmed
20978819
uniprot
proteins
pubmed
21102408
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21499297
uniprot
proteins
pubmed
22609399
uniprot
proteins
pubmed
23776465
uniprot
proteins
pubmed
26456823
uniprot
proteins
pubmed
8837781
uniprot
proteins
pubmed
9341143
uniprot
proteins
pubmed
9535219
uniprot
proteins
sequence_length
334
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:17050680, ECO:0000269|PubMed:20978819, ECO:0000269|PubMed:22609399, ECO:0000269|PubMed:9535219}. Nucleus {ECO:0000269|PubMed:17050680, ECO:0000269|PubMed:20978819, ECO:0000269|PubMed:22609399}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:9535219}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000269|PubMed:21102408}. Note=Nuclear localization is diminished in the presence of IFIT3. {ECO:0000269|PubMed:17050680}.
uniprot
proteins