Dcaf1
entrez
321006
canonical
uniprot
Q80TR8
canonical
ensembl
ENSMUSG00000040325
resolver
ensp
ENSMUSP00000060025
resolver
ensp
ENSMUSP00000123865
resolver
ensp
ENSMUSP00000166924
resolver
ensp
ENSMUSP00000328219
resolver
genesymbol
Dcaf1
resolver
genesymbol_syn
Kiaa0800
resolver
genesymbol_syn
Vprbp
resolver
uniprot
Q3UXD5
resolver
uniprot
Q6P1E2
resolver
uniprot
Q8CDY3
resolver
uniprot_entry
DCAF1_MOUSE
resolver
uniprot_sec
Q3UXD5
resolver
uniprot_sec
Q6P1E2
resolver
uniprot_sec
Q8CDY3
resolver
amino_acid_sequence
MTTVVVHVDSKAELTTLLEQWEKDHGSGQDMVPILTRMSELIEKETEEYRKGDPDPFDDRHPGRADPECMLGHLLRILFKNDDFMNALVNAYVMTSREPPLNTAACRLLLDIMPGLETAVVFQEKEGIVENLFKWAREADQPLRTYSTGLLGGAMENQDIAANYRDENSQLVAIVLRRLRELQLQEVALRQDSKRPSPRKLSSEPLLPLDEEAVDMDYGDMAVDVVDGEQESSRDMEISFRLDSSHKTSSRVNSATKPEEGGLKKNKSAKHGDRENFRKAKQKLGFSSSDPDRVFVELSNSSWSEMSPWVIGTNYTLYPMTPAIEQRLILQYLTPLGEYQELLPIFMQLGSRELMMFYIDLKQTNDVLLTFEALKHLASLLLHNKFATEFVAHGGVQKLLEIPRPSMAATGVSMCLYYLSYNQDAMERVCMHPHNVLSDVVNYTLWLMECSHASGCCHATMFFSICFSFRAVLELFDRYDGLRRLVNLISTLEILNLEDQGALLSDDEIFASRQTGKHTCMALRKYFEAHLAIKLEQVKQSLQRTEGGILVHPQPPYKACSYTHEQIVEMMEFLIEYGPAQLYWEPAEVFLKLSCVQLLLQLISIACNWKTYYARNDTVRFALDVLAILTVVPKIQLQLAESVDVLDEAGSAVSTVGISIILGVAEGEFFIHDAEIQKSALQIIINCVCGPDNRISSIGKFISGTPRRKLSQTPKSSEHTLAKMWNVVQSNNGIKVLLSLLSIKMPITDADQIRALACKALVGLSRSSTVRQIISKLPLFSSCQIQQLMKEPVLQDKRSDHVKFCKYAAELIERVSGKPLLIGTDVSLARLQKADVVAQSRISFPEKELLLLIRNHLISKGLGETATVLTREADLPMTAASHSSAFTPVTAAASPVSLPRTPRIANGIASRLGSHATVGASAPSAPPAHPPPRPPQGSLPLPGPSYAGNSPLIGRISFIRERPSPCNGRKIRVLRQKSDHGAYSQSPAIKKQLDRHLPSPPTLDSIITEYLREQHARCKNPVATCPPFSLFTPHQCPEPKQRRQAPINFTSRLNRRASFPKYGGVDGGCFDRHLIFSRFRPISVFREANEDESGFTCCAFSARERFLMLGTCTGQLKLYNVFSGQEEASYNCHNSAITHLEPSRDGSLLLTSATWSQPLSALWGMKSVFDMKHSFTEDHYVEFSKHSQDRVIGTKGDIAHIYDIQTGNKLLTLFNPDLANNYKRNCATFNPTDDLVLNDGVLWDVRSAQAIHKFDKFNMNISGVFHPNGLEVIINTEIWDLRTFHLLHTVPALDQCRVVFNHTGTVMYGAMLQADDEDDLLEERMKSPFGSSFRTFNATDYKPIATIDVKRNIFDLCTDTKDCYLAVIENQGSMDALNMDTVCRLYEVGRQRLAEDEDEEEDQEEEEQEEEDDDEDDDDTDDLDELDTDQLLEAELEEDDNNENAGEDGDNDFSPSDEELANLLEEGEEGEDEDSDADEEVELILGDTDSSDNSDLEDDIILSLNE
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification (By similarity). Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2 (By similarity). Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (By similarity). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination (PubMed:22157821). Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition (By similarity). The EDVP complex also mediates ubiquitination and degradation of CCP110 (By similarity). Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription (By similarity). H2AT120ph is present in the regulatory region of many tumor suppresor genes, down-regulates their transcription and is present at high level in a number of tumors (By similarity). Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2 (By similarity). By acting on TET dioxygenses, essential for oocyte maintenance at the primordial follicle stage, hence essential for female fertility (PubMed:24357321). {ECO:0000250|UniProtKB:Q9Y4B6, ECO:0000269|PubMed:22157821, ECO:0000269|PubMed:24357321}.
uniprot
proteins
mass_dalton
168931
uniprot
proteins
mutagenesis
MUTAGEN 1246; /note="R->A: Loss of interaction with DDB1 and strong decrease in TET2 monoubiquitination; when associated with A-1282."; /evidence="ECO:0000269|PubMed:24357321"; MUTAGEN 1282; /note="R->A: Loss of interaction with DDB1 and strong decrease in TET2 monoubiquitination; when associated with A-1246."; /evidence="ECO:0000269|PubMed:24357321
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
VPRBP/DCAF1 family
uniprot
proteins
pubmed
11223251
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18606781
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22157821
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
24357321
uniprot
proteins
pubmed
25557551
uniprot
proteins
pubmed
36056023
uniprot
proteins
sequence_length
1506
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24357321}. Nucleus {ECO:0000269|PubMed:24357321, ECO:0000269|PubMed:25557551, ECO:0000269|PubMed:36056023}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9Y4B6}. Note=Associated with chromatin in a DDB1-independent and cell cycle-dependent manner: recruited to chromatin as DNA is being replicated and is released from chromatin before mitosis (PubMed:36056023). Homogeneous pancellular distribution is observed outside S-phase and a slight cytoplasmic-to-nuclear translocation from early to late S-phase (PubMed:36056023). Colocalizes with TET1 and PCNA at replicating heterochromatin during late S phase (PubMed:36056023). More concentrated in nuclei than in cytoplasm in germinal vesicle (GV) stage oocytes, zygotes and the 2-cell stage, but distributed in the cytoplasm at the MII-stage oocytes (PubMed:24357321). Localizes to centrosomes following interaction with CEP78 (By similarity). {ECO:0000250|UniProtKB:Q9Y4B6, ECO:0000269|PubMed:24357321, ECO:0000269|PubMed:36056023}.
uniprot
proteins