NKG7
entrez
4818
canonical
uniprot
Q16617
canonical
ensembl
ENSG00000105374
resolver
ensp
ENSP00000221978
resolver
ensp
ENSP00000468910
resolver
ensp
ENSP00000772821
resolver
enst
ENST00000221978
resolver
enst
ENST00000595217
resolver
genesymbol
NKG7
resolver
genesymbol_syn
GIG1
resolver
hgnc
HGNC:7830
resolver
uniprot
A0A0B4J2A6
resolver
uniprot_entry
A0A0B4J2A6_HUMAN
resolver
uniprot_entry
NKG7_HUMAN
resolver
amino_acid_sequence
MELCRSLALLGGSLGLMFCLIALSTDFWFEAVGPTHSAHSGLWPTGHGDIISGYIHVTQTFSIMAVLWALVSVSFLVLSCFPSLFPPGHGPLVSTTAAFAAAISMVVAMAVYTSERWDQPPHPQIQTFFSWSFYLGWVSAILLLCTGALSLGAHCGGPRPGYETL
uniprot
proteins
function
FUNCTION: Regulates cytotoxic granule exocytosis in effector lymphocytes, thus acting as a critical mediator of inflammation in a broad range of infectious and non-infectious diseases (By similarity). Essential for cytotoxic degranulation of natural killer (NK) cells and CD8(+) T-cells and for the activation of CD4(+) T-cells following infection (By similarity). Plays a critical role in CD8(+) T-cell and NK cell-mediated cytolysis of target cells and contributes to the cytolytic activity via the perforin/granzyme pathway by enhancing exocytosis of LAMP1-carrying lytic granules (By similarity). Contributes to NK cell-mediated control of cancer metastasis (By similarity). {ECO:0000250|UniProtKB:Q99PA5}.
uniprot
proteins
mass_dalton
17665
uniprot
proteins
protein_family
PMP-22/EMP/MP20 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
32839608
uniprot
proteins
pubmed
7510105
uniprot
proteins
pubmed
8458737
uniprot
proteins
pubmed
8570616
uniprot
proteins
sequence_length
165
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8570616}; Multi-pass membrane protein {ECO:0000269|PubMed:8570616}. Cytolytic granule membrane {ECO:0000269|PubMed:8570616}; Multi-pass membrane protein {ECO:0000269|PubMed:8570616}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 61..81; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 92..112; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 133..153; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins