KCNV1
entrez
27012
canonical
uniprot
Q6PIU1
canonical
ensembl
ENSG00000164794
resolver
ensp
ENSP00000297404
resolver
ensp
ENSP00000435954
resolver
enst
ENST00000297404
resolver
enst
ENST00000524391
resolver
genesymbol
KCNV1
resolver
hgnc
HGNC:18861
resolver
uniprot
Q9UHJ4
resolver
uniprot_entry
KCNV1_HUMAN
resolver
uniprot_sec
Q9UHJ4
resolver
amino_acid_sequence
MPSSGRALLDSPLDSGSLTSLDSSVFCSEGEGEPLALGDCFTVNVGGSRFVLSQQALSCFPHTRLGKLAVVVASYRRPGALAAVPSPLELCDDANPVDNEYFFDRSSQAFRYVLHYYRTGRLHVMEQLCALSFLQEIQYWGIDELSIDSCCRDRYFRRKELSETLDFKKDTEDQESQHESEQDFSQGPCPTVRQKLWNILEKPGSSTAARIFGVISIIFVVVSIINMALMSAELSWLDLQLLEILEYVCISWFTGEFVLRFLCVRDRCRFLRKVPNIIDLLAILPFYITLLVESLSGSQTTQELENVGRIVQVLRLLRALRMLKLGRHSTGLRSLGMTITQCYEEVGLLLLFLSVGISIFSTVEYFAEQSIPDTTFTSVPCAWWWATTSMTTVGYGDIRPDTTTGKIVAFMCILSGILVLALPIAIINDRFSACYFTLKLKEAAVRQREALKKLTKNIATDSYISVNLRDVYARSIMEMLRLKGRERASTRSSGGDDFWF
uniprot
proteins
function
FUNCTION: Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes. {ECO:0000269|PubMed:8670833, ECO:0000269|PubMed:9079713}.
uniprot
proteins
mass_dalton
56304
uniprot
proteins
protein_family
Kv8.1/KCNV1 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
protein_family
V (TC 1.A.1.2) subfamily
uniprot
proteins
pubmed
12383276
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8670833
uniprot
proteins
pubmed
9079713
uniprot
proteins
sequence_length
500
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8670833, ECO:0000269|PubMed:9079713}; Multi-pass membrane protein {ECO:0000269|PubMed:8670833, ECO:0000269|PubMed:9079713}. Note=Has to be associated with another potassium channel subunit to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB2.
uniprot
proteins
transmembrane_region
TRANSMEM 211..231; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 239..259; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 277..297; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 310..331; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 346..366; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 407..427; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins