ARMH4
entrez
145407
canonical
uniprot
Q86TY3
canonical
ensembl
ENSG00000139971
resolver
ensp
ENSP00000267485
resolver
genesymbol
ARMH4
resolver
genesymbol
C14orf37
resolver
genesymbol_syn
C14orf37
resolver
hgnc
HGNC:19846
resolver
uniprot
A8K8Z8
resolver
uniprot
B2RUU6
resolver
uniprot
Q6P5Q1
resolver
uniprot
Q86TY1
resolver
uniprot_entry
ARMD4_HUMAN
resolver
uniprot_entry
B2RUU6_HUMAN
resolver
uniprot_sec
A8K8Z8
resolver
uniprot_sec
Q6P5Q1
resolver
uniprot_sec
Q86TY1
resolver
amino_acid_sequence
MRGPIVLHICLAFCSLLLFSVATQCLAFPKIERRREIAHVHAEKGQSDKMNTDDLENSSVTSKQTPQLVVSEDPMMMSAVPSATSLNKAFSINKETQPGQAGLMQTERPGVSTPTESGVPSAEEVFGSSQPERISPESGLAKAMLTIAITATPSLTVDEKEELLTSTNFQPIVEEITETTKGFLKYMDNQSFATESQEGVGLGHSPSSYVNTKEMLTTNPKTEKFEADTDHRTTSFPGAESTAGSEPGSLTPDKEKPSQMTADNTQAAATKQPLETSEYTLSVEPETDSLLGAPEVTVSVSTAVPAASALSDEWDDTKLESVSRIRTPKLGDNEETQVRTEMSQTAQVSHEGMEGGQPWTEAAQVALGLPEGETHTGTALLIAHGNERSPAFTDQSSFTPTSLMEDMKVSIVNLLQSTGDFTESTKENDALFFLETTVSVSVYESEADQLLGNTMKDIITQEMTTAVQEPDATLSMVTQEQVATLELIRDSGKTEEEKEDPSPVSDVPGVTQLSRRWEPLATTISTTVVPLSFEVTPTVEEQMDTVTGPNEEFTPVLGSPVTPPGIMVGEPSISPALPALEASSERRTVVPSITRVNTAASYGLDQLESEEGQEDEDEEDEEDEDEEEEDEEEDEEDKDADSLDEGLDGDTELPGFTLPGITSQEPGLEEGNMDLLEGATYQVPDALEWEQQNQGLVRSWMEKLKDKAGYMSGMLVPVGVGIAGALFILGALYSIKVMNRRRRNGFKRHKRKQREFNSMQDRVMLLADSSEDEF
uniprot
proteins
function
FUNCTION: May modulate immune response and may play a role in inflammation (PubMed:36649229). Down-modulates STAT3 signaling throught direct interaction with IL6ST, resulting in the inhibition of phosphorylation of STAT3 at 'Tyr-705' (PubMed:26927669). May negatively regulates AKT signaling by modulating the activity of mTORC2 complex through RICTOR interaction (By similarity). {ECO:0000250|UniProtKB:Q8BT18, ECO:0000269|PubMed:26927669, ECO:0000269|PubMed:36649229}.
uniprot
proteins
mass_dalton
84173
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
26927669
uniprot
proteins
pubmed
36649229
uniprot
proteins
sequence_length
774
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:36649229}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 715..735; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins