HDAC7
entrez
51564
canonical
uniprot
Q8WUI4
canonical
ensembl
ENSG00000061273
resolver
ensp
ENSP00000080059
resolver
ensp
ENSP00000351326
resolver
ensp
ENSP00000404394
resolver
ensp
ENSP00000448532
resolver
ensp
ENSP00000573492
resolver
ensp
ENSP00000671658
resolver
genesymbol
HDAC7
resolver
genesymbol_syn
HDAC7A
resolver
hgnc
HGNC:14067
resolver
uniprot
B3KY08
resolver
uniprot
B4DWI0
resolver
uniprot
B4E0Q5
resolver
uniprot
Q6P1W9
resolver
uniprot
Q6W9G7
resolver
uniprot
Q7Z4K2
resolver
uniprot
Q7Z5I1
resolver
uniprot
Q96K01
resolver
uniprot
Q9BR73
resolver
uniprot
Q9H7L0
resolver
uniprot
Q9NW41
resolver
uniprot
Q9NWA9
resolver
uniprot
Q9NYK9
resolver
uniprot
Q9UFU7
resolver
uniprot_entry
HDAC7_HUMAN
resolver
uniprot_sec
B3KY08
resolver
uniprot_sec
B4DWI0
resolver
uniprot_sec
B4E0Q5
resolver
uniprot_sec
Q6P1W9
resolver
uniprot_sec
Q6W9G7
resolver
uniprot_sec
Q7Z4K2
resolver
uniprot_sec
Q7Z5I1
resolver
uniprot_sec
Q96K01
resolver
uniprot_sec
Q9BR73
resolver
uniprot_sec
Q9H7L0
resolver
uniprot_sec
Q9NW41
resolver
uniprot_sec
Q9NWA9
resolver
uniprot_sec
Q9NYK9
resolver
uniprot_sec
Q9UFU7
resolver
amino_acid_sequence
MDLRVGQRPPVEPPPEPTLLALQRPQRLHHHLFLAGLQQQRSVEPMRLSMDTPMPELQVGPQEQELRQLLHKDKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSSFLPPVPSLPSDPPEHFPLRKTVSEPNLKLRYKPKKSLERRKNPLLRKESAPPSLRRRPAETLGDSSPSSSSTPASGCSSPNDSEHGPNPILGSEALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAPARADSDRRTHPTLGPRGPILGSPHTPLFLPHGLEPEAGGTLPSRLQPILLLDPSGSHAPLLTVPGLGPLPFHFAQSLMTTERLSGSGLHWPLSRTRSEPLPPSATAPPPPGPMQPRLEQLKTHVQVIKRSAKPSEKPRLRQIPSAEDLETDGGGPGQVVDDGLEHRELGHGQPEARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVLLPLAQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIYDSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSERHVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGSVTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIVDWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGGLDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMTQQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSLEAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVEAVTALASLSVGILAEDRPSEQLVEEEEPMNL
uniprot
proteins
ec_number
3.5.1.-
uniprot
proteins
ec_number
3.5.1.98
uniprot
proteins
function
FUNCTION: Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C (By similarity). During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity). May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene (PubMed:12239305). Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565). Serves as a corepressor of RARA, causing its deacetylation and inhibition of RARE DNA element binding (PubMed:28167758). In association with RARA, plays a role in the repression of microRNA-10a and thereby in the inflammatory response (PubMed:28167758). Also acetylates non-histone proteins, such as ALKBH5 (PubMed:37369679). {ECO:0000250|UniProtKB:Q8C2B3, ECO:0000269|PubMed:12239305, ECO:0000269|PubMed:17360565, ECO:0000269|PubMed:28167758, ECO:0000269|PubMed:37369679}.
uniprot
proteins
mass_dalton
102927
uniprot
proteins
mutagenesis
MUTAGEN 150; /note="L->A: Abolishes phosphorylation at S-155."; /evidence="ECO:0000269|PubMed:16980613"; MUTAGEN 155; /note="S->A: Abolishes nuclear export; when associated with A-181; A-358 and A-486. Abolishes phosphorylation by MARK2 and MARK3, interaction with 14-3-3 and localization to the cytoplasm."; /evidence="ECO:0000269|PubMed:16980613"; MUTAGEN 181; /note="S->A: Abolishes nuclear export; when associated with A-155; A-358 and A-486."; /evidence="ECO:0000269|PubMed:16980613"; MUTAGEN 358; /note="S->A: Abolishes nuclear export; when associated with A-192; A-1118 and A-486."; /evidence="ECO:0000269|PubMed:16980613"; MUTAGEN 486; /note="S->A: Abolishes nuclear export; when associated with A-192; A-1118 and A-358."; /evidence="ECO:0000269|PubMed:16980613"; MUTAGEN 843; /note="H->A: Enhanced deacetylase activity."; /evidence="ECO:0000269|PubMed:18285338"; MUTAGEN 843; /note="H->F: Enhanced deacetylase activity."; /evidence="ECO:0000269|PubMed:18285338"; MUTAGEN 843; /note="H->Y: 6000 fold increase in deacetylase activity."; /evidence="ECO:0000269|PubMed:18285338
uniprot
proteins
post_translational_modification
PTM: May be phosphorylated by CaMK1. Phosphorylated by the PKC kinases PKN1 and PKN2, impairing nuclear import. Phosphorylation at Ser-155 by MARK2, MARK3 and PRKD1 promotes interaction with 14-3-3 proteins and export from the nucleus. Phosphorylation at Ser-155 is a prerequisite for phosphorylation at Ser-181. {ECO:0000269|PubMed:16980613, ECO:0000269|PubMed:17962809, ECO:0000269|PubMed:20188095}.
uniprot
proteins
protein_family
HD type 2 subfamily
uniprot
proteins
protein_family
Histone deacetylase family
uniprot
proteins
pubmed
11262386
uniprot
proteins
pubmed
11466315
uniprot
proteins
pubmed
12239305
uniprot
proteins
pubmed
12551922
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
16980613
uniprot
proteins
pubmed
17360565
uniprot
proteins
pubmed
17373667
uniprot
proteins
pubmed
17962809
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18285338
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20188095
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22155184
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28167758
uniprot
proteins
pubmed
37369679
uniprot
proteins
sequence_length
952
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11262386, ECO:0000269|PubMed:16980613}. Cytoplasm {ECO:0000269|PubMed:16980613}. Note=In the nucleus, it associates with distinct subnuclear dot-like structures (PubMed:11262386). Shuttles between the nucleus and the cytoplasm (PubMed:16980613). In muscle cells, it shuttles into the cytoplasm during myocyte differentiation (By similarity). The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation (PubMed:16980613). {ECO:0000250|UniProtKB:Q8C2B3, ECO:0000269|PubMed:11262386, ECO:0000269|PubMed:16980613}.
uniprot
proteins