Stim1
entrez
20866
canonical
uniprot
P70302
canonical
ensembl
ENSMUSG00000030987
resolver
ensp
ENSMUSP00000033289
resolver
ensp
ENSMUSP00000147410
resolver
ensp
ENSMUSP00000147443
resolver
enst
ENSMUST00000033289
resolver
enst
ENSMUST00000209255
resolver
enst
ENSMUST00000211457
resolver
genesymbol
Stim1
resolver
genesymbol_syn
Sim
resolver
uniprot
A0A1B0GR78
resolver
uniprot
A0A1B0GRA5
resolver
uniprot
Q8K1E1
resolver
uniprot_entry
A0A1B0GR78_MOUSE
resolver
uniprot_entry
A0A1B0GRA5_MOUSE
resolver
uniprot_entry
STIM1_MOUSE
resolver
uniprot_sec
Q8K1E1
resolver
amino_acid_sequence
MDVCARLALWLLWGLLLHQGQSLSHSHSEKNTGASSGATSEESTEAEFCRIDKPLCHSEDEKLSFEAVRNIHKLMDDDANGDVDVEESDEFLREDLNYHDPTVKHSTFHGEDKLISVEDLWKAWKSSEVYNWTVDEVIQWLITYVELPQYEETFRKLQLTGHAMPRLAVTNTTMTGTVLKMTDRSHRQKLQLKALDTVLFGPPLLTRHNHLKDFMLVVSIVIGVGGCWFAYIQNRYSKEHMKKMMKDLEGLHRAEQSLHDLQERLHKAQEEHRTVEVEKVHLEKKLRDEINLAKQEAQRLKELREGTENERSRQKYAEEELEQVREALRKAEKELESHSSWYAPEALQKWLQLTHEVEVQYYNIKKQNAERQLLVAKEGAEKIKKKRNTLFGTFHVAHSSSLDDVDHKILTAKQALSEVTAALRERLHRWQQIEILCGFQIVNNPGIHSLVAALNIDPSWMGSTRPNPAHFIMTDDVDDMDEEIVSPLSMQSPSLQSSVRQRLTEPQLGLGSQRDLTHSDSESSLHMSDRQRVAPKPPQMGRAADEALNAMPSNGSHRLIEGVHPGSLVEKLPDSPALAKKTFMALNHGLDKAHSLMELNPSVPPGGSPLLDSSHSLSPSSPDPDTPSPVGDNRALQGSRNTRIPHLAGKKAMAEEDNGSIGEETDSSPGRKKFPLKIFKKPLKK
uniprot
proteins
function
FUNCTION: Acts as a Ca(2+) sensor that gates two major inward rectifying Ca(2+) channels at the plasma membrane: Ca(2+) release-activated Ca(2+) (CRAC) channels and arachidonate-regulated Ca(2+)-selective (ARC) channels. Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates CRAC channel pore-forming subunits ORA1, ORA2 and ORAI3 to generate sustained and oscillatory Ca(2+) entry. Involved in enamel formation. Plays a role in regulating the type I interferon response by retaining the signaling adapter STING at the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q13586}.
uniprot
proteins
mass_dalton
77567
uniprot
proteins
post_translational_modification
PTM: Glycosylation is required for cell surface expression. {ECO:0000250|UniProtKB:Q13586}.; PTM: Phosphorylated predominantly on Ser residues. {ECO:0000250|UniProtKB:Q13586}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17208939
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24621671
uniprot
proteins
pubmed
26644563
uniprot
proteins
pubmed
31346090
uniprot
proteins
pubmed
8707854
uniprot
proteins
sequence_length
685
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q13586}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q13586}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q13586}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q13586}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q13586}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q13586}. Note=Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium and is detected at punctae corresponding to junctions between the endoplasmic reticulum and the cell membrane. Associated with the microtubule network at the growing distal tip of microtubules. Colocalizes with ORAI1 at the cell membrane. Colocalizes preferentially with CASQ1 at endoplasmic reticulum in response to a depletion of intracellular calcium. {ECO:0000250|UniProtKB:Q13586}.
uniprot
proteins
transmembrane_region
TRANSMEM 214..234; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins