Get3
entrez
288919
canonical
uniprot
G3V9T7
canonical
ensembl
ENSRNOG00000003747
resolver
ensembl
ENSRNOG00055007656
resolver
ensembl
ENSRNOG00060016148
resolver
ensembl
ENSRNOG00065010237
resolver
ensp
ENSRNOP00000059647
resolver
ensp
ENSRNOP00055010208
resolver
ensp
ENSRNOP00060022196
resolver
ensp
ENSRNOP00065012552
resolver
enst
ENSRNOT00000067518
resolver
enst
ENSRNOT00055012807
resolver
enst
ENSRNOT00060027637
resolver
enst
ENSRNOT00065016508
resolver
genesymbol
Get3
resolver
genesymbol_syn
Asna1
resolver
genesymbol_syn
Trc40
resolver
uniprot
Q4G022
resolver
uniprot_entry
GET3_RAT
resolver
uniprot_entry
Q4G022_RAT
resolver
amino_acid_sequence
MAAGVAGWGVEAEEFEDAPDVEPLEPTLSNIIEQRSLKWIFVGGKGGVGKTTCSCSLAVQLSKGRESVLIISTDPAHNISDAFDQKFSKVPTKVKGYDNLFAMEIDPSLGVAELPDEFFEEDNMLSMGKKMMQEAMSAFPGIDEAMSYAEVMRLVKGMNFSVVVFDTAPTGHTLRLLNFPTIVERGLGRLMQIKNQISPFISQMCNMLGLGDMNADQLASKLEETLPVIRSVSEQFKDPEQTTFICVCIAEFLSLYETERLIQELAKCKIDTHNIIVNQLVFPDPEKPCKMCEARHKIQAKYLDQMEDLYEDFHIVKLPLLPHEVRGADKVNTFSALLLEPYKPPSTQ
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-CAMLG receptor, and returning it to the cytosol to initiate a new round of targeting. {ECO:0000255|HAMAP-Rule:MF_03112, ECO:0000269|PubMed:23041287, ECO:0000269|PubMed:27226539}.
uniprot
proteins
mass_dalton
38823
uniprot
proteins
protein_family
ArsA ATPase family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
23041287
uniprot
proteins
pubmed
27226539
uniprot
proteins
sequence_length
348
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O43681, ECO:0000255|HAMAP-Rule:MF_03112}. Endoplasmic reticulum {ECO:0000250|UniProtKB:O43681, ECO:0000255|HAMAP-Rule:MF_03112}. Nucleus, nucleolus {ECO:0000250|UniProtKB:O43681, ECO:0000255|HAMAP-Rule:MF_03112}.
uniprot
proteins