Parpbp
entrez
75317
canonical
uniprot
Q6IRT3
canonical
ensembl
ENSMUSG00000035365
resolver
ensp
ENSMUSP00000038375
resolver
ensp
ENSMUSP00000128043
resolver
ensp
ENSMUSP00000268980
resolver
enst
ENSMUST00000048518
resolver
genesymbol
Parpbp
resolver
genesymbol_syn
Pari
resolver
uniprot
A0A0R4J0G5
resolver
uniprot
Q3UAQ9
resolver
uniprot
Q3V278
resolver
uniprot
Q8C0J4
resolver
uniprot_entry
A0A0R4J0G5_MOUSE
resolver
uniprot_entry
PARI_MOUSE
resolver
uniprot_sec
Q3UAQ9
resolver
uniprot_sec
Q3V278
resolver
uniprot_sec
Q8C0J4
resolver
amino_acid_sequence
MAVLNQLPVLGMIKEFRRSWRALCSSERTTLCGPDSMLLALQLSMAENNKQHRGEFTVCLSDVLLTWKYFLHEKLNLPIENMKVVEHYEDIKKTYDDFLKNSNTLDLIDVYKKCSSLTSNYENNMISPIQLRDFLSGTEYAVSDEANPHMPESPVKCSQNDEQVRVLVKKIFFSYLSLLVNSKNDLALASILNIPDRGLGREAFTNLKHAAREKQLSMFLMATSFIRTLELGGKGYAPSPSDPLWAHVKGLSEFINFIDKLDEILGKIPNPSLAGSRILSAIKMQLIKGHSSGEPFYKAVEEVVQDLNLRIKNIINSQEGVAVSANNISPVPPKSFAINHDTAYCGRDAVKILLVLLDEDAASAPTRNKAELLYNDESTVPHSGPSVLTLFRSPTQEKNTSVKPLRERIHKSLQTEKNKMWQTLIRSQFACTYKDDCIMSKNKWHVNSSSKPLSALHLEDDVSEGAQSSVGKARIEASSENAHVGRWKGDKLPRKSTQRQISKGKQLDLDSENLHCDRGNELYQHKNIKIPKVPSGSHSKAGGKLAQGTKGNRCPARGKLIPGQTKLTQFFML
uniprot
proteins
function
FUNCTION: Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
64105
uniprot
proteins
protein_family
PARI family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
31112734
uniprot
proteins
pubmed
34272044
uniprot
proteins
sequence_length
573
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Localizes to chromatin in response to S phase arrest but not in mitosis. Targeted to chromatin via its interaction with PCNA (By similarity). {ECO:0000250}.
uniprot
proteins