TMEM108
entrez
66000
canonical
uniprot
Q6UXF1
canonical
ensembl
ENSG00000144868
resolver
ensp
ENSP00000324651
resolver
ensp
ENSP00000376838
resolver
ensp
ENSP00000424897
resolver
ensp
ENSP00000600571
resolver
ensp
ENSP00000600572
resolver
ensp
ENSP00000600579
resolver
enst
ENST00000508711
resolver
enst
ENST00000930512
resolver
enst
ENST00000930513
resolver
enst
ENST00000930520
resolver
genesymbol
TMEM108
resolver
genesymbol_syn
KIAA1690
resolver
genesymbol_syn
RTLN
resolver
hgnc
HGNC:28451
resolver
uniprot
A0ACI8TJ86
resolver
uniprot
B3KT64
resolver
uniprot
D3DNC9
resolver
uniprot
Q9BQH1
resolver
uniprot
Q9BW81
resolver
uniprot
Q9C0H3
resolver
uniprot_entry
A0ACI8TJ86_HUMAN
resolver
uniprot_entry
B3KT64_HUMAN
resolver
uniprot_entry
TM108_HUMAN
resolver
uniprot_sec
D3DNC9
resolver
uniprot_sec
Q9BQH1
resolver
uniprot_sec
Q9BW81
resolver
uniprot_sec
Q9C0H3
resolver
amino_acid_sequence
MKRSLQALYCQLLSFLLILALTEALAFAIQEPSPRESLQVLPSGTPPGTMVTAPHSSTRHTSVVMLTPNPDGPPSQAAAPMATPTPRAEGHPPTHTISTIAATVTAPHSESSLSTGPAPAAMATTSSKPEGRPRGQAAPTILLTKPPGATSRPTTAPPRTTTRRPPRPPGSSRKGAGNSSRPVPPAPGGHSRSKEGQRGRNPSSTPLGQKRPLGKIFQIYKGNFTGSVEPEPSTLTPRTPLWGYSSSPQPQTVAATTVPSNTSWAPTTTSLGPAKDKPGLRRAAQGGGSTFTSQGGTPDATAASGAPVSPQAAPVPSQRPHHGDPQDGPSHSDSWLTVTPGTSRPLSTSSGVFTAATGPTPAAFDTSVSAPSQGIPQGASTTPQAPTHPSRVSESTISGAKEETVATLTMTDRVPSPLSTVVSTATGNFLNRLVPAGTWKPGTAGNISHVAEGDKPQHRATICLSKMDIAWVILAISVPISSCSVLLTVCCMKRKKKTANPENNLSYWNNTITMDYFNRHAVELPREIQSLETSEDQLSEPRSPANGDYRDTGMVLVNPFCQETLFVGNDQVSEI
uniprot
proteins
function
FUNCTION: Transmembrane protein required for proper cognitive functions. Involved in the development of dentate gyrus (DG) neuron circuitry, is necessary for AMPA receptors surface expression and proper excitatory postsynaptic currents of DG granule neurons. Regulates the organization and stability of the microtubule network of sensory neurons to allow axonal transport. Through the interaction with DST, mediates the docking of the dynein/dynactin motor complex to vesicle cargos for retrograde axonal transport. In hippocampal neurons, required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 and recruits the WAVE1 complex to facilitate actin-dependent BDNF:NTRK2 early endocytic trafficking and mediate signaling from early endosomes. {ECO:0000250|UniProtKB:Q8BHE4}.
uniprot
proteins
mass_dalton
59948
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:Q8BHE4}.
uniprot
proteins
pubmed
11214970
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
575
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q8BHE4}; Multi-pass membrane protein {ECO:0000255}. Postsynaptic density {ECO:0000250|UniProtKB:Q8BHE4}. Endosome membrane {ECO:0000250|UniProtKB:Q8BHE4}. Cell projection, axon {ECO:0000250|UniProtKB:Q8BHE4}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8BHE4}. Early endosome {ECO:0000250|UniProtKB:Q8BHE4}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 469..489; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins