Nox1
entrez
114243
canonical
uniprot
Q9WV87
canonical
ensembl
ENSRNOG00000048706
resolver
ensp
ENSRNOP00000065995
resolver
enst
ENSRNOT00000075325
resolver
genesymbol
Nox1
resolver
genesymbol_syn
Mox1
resolver
genesymbol_syn
Noh1
resolver
uniprot
M0R934
resolver
uniprot_entry
M0R934_RAT
resolver
uniprot_entry
NOX1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: The oxidase activity is potentiated by NOXA1 and NOXO1. {ECO:0000250|UniProtKB:Q9Y5S8}.
uniprot
proteins
amino_acid_sequence
MGNWLVNHWLSVLFLVSWLGLNIFLFVYVFLNYEKSDKYYYTREILGTALALARASALCLNFNSMVILIPVCRNLLSFLRGTCSFCNHTLRKPLDHNLTFHKLVAYMICIFTAIHIIAHLFNFERYSRSQQAMDGSLASVLSSLFHPEKEDSWLNPIQSPNVTVMYAAFTSIAGLTGVVATVALVLMVTSAMEFIRRNYFELFWYTHHLFIIYIICLGIHGLGGIVRGQTEESMSESHPRNCSYSFHEWDKYERSCRSPHFVGQPPESWKWILAPIAFYIFERILRFYRSRQKVVITKVVMHPCKVLELQMRKRGFTMGIGQYIFVNCPSISFLEWHPFTLTSAPEEEFFSIHIRAAGDWTENLIRTFEQQHSPMPRIEVDGPFGTVSEDVFQYEVAVLVGAGIGVTPFASFLKSIWYKFQRAHNKLKTQKIYFYWICRETGAFAWFNNLLNSLEQEMDELGKPDFLNYRLFLTGWDSNIAGHAALNFDRATDVLTGLKQKTSFGRPMWDNEFSRIATAHPKSVVGVFLCGPPTLAKSLRKCCRRYSSLDPRKVQFYFNKETF
uniprot
proteins
ec_number
1.6.3.-
uniprot
proteins
function
FUNCTION: NADPH oxidase that catalyzes the generation of superoxide from molecular oxygen utilizing NADPH as an electron donor. {ECO:0000269|PubMed:10485709, ECO:0000269|PubMed:25228390}.
uniprot
proteins
mass_dalton
65177
uniprot
proteins
mutagenesis
MUTAGEN 89; /note="T->A: No effect on catalytic activity."; /evidence="ECO:0000269|PubMed:25228390"; MUTAGEN 429; /note="T->A: Loss of catalytic activity."; /evidence="ECO:0000269|PubMed:25228390
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-429 mediated by PKC/PRKBC positively regulates its interaction with NOXA1 and enzyme activity. {ECO:0000269|PubMed:25228390}.
uniprot
proteins
pubmed
10485709
uniprot
proteins
pubmed
25228390
uniprot
proteins
sequence_length
563
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, invadopodium membrane {ECO:0000250|UniProtKB:Q9Y5S8}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9Y5S8}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..31; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 45..69; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 103..123; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 168..188; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 207..227; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 396..416; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins