Spef2
entrez
320277
canonical
uniprot
Q8C9J3
canonical
ensembl
ENSMUSG00000072663
resolver
ensp
ENSMUSP00000035762
resolver
ensp
ENSMUSP00000124723
resolver
ensp
ENSMUSP00000311478
resolver
genesymbol
Spef2
resolver
genesymbol_syn
Kpl2
resolver
uniprot
A2RSG5
resolver
uniprot
E0CYG3
resolver
uniprot
G0Z098
resolver
uniprot_entry
SPEF2_MOUSE
resolver
uniprot_sec
A2RSG5
resolver
uniprot_sec
E0CYG3
resolver
uniprot_sec
G0Z098
resolver
amino_acid_sequence
MSEILCQWLNQELRVSRTVSPKSFAKAFSNGYLIGEVLFKFELQSDFAEFSESRGSTAKLNNFSRLQPTLHLLGLQFDQNVAQSIITEKPGAATKLLYQLYIALQKKKKTGLTGLEIQTMQPQTNLRLQTLKSEAFREQRLNRRRQNEIMAKIQAAIIQIPKPESNRTLKAIEAQKLMKKKKEAEDVANEIKKFEALIKKDLQIKESVSKTSLETTDQTTAELLNTYSDDDYIKKIQKRLEEDAFAREQREKRRRRLLMDQLMAHEAQEEAYREEQLIHRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQFEERRLKDFQDALDREAALAKQAKIDFAEQTLREKEIHEKISVERAQQRYKKHYGICAEILDQMLDLCTKVADYRLLTNNLIPHKMMHDWKELFFSGIPIYEQTSLTHGQTEPTEDHRAEVKKRNLLDSKDYEDYKNMVGEWALPEDMVNSSPPSNNSILGHVLLRLIEKADPSASNAEATELPSLAVKGCILGKTLSGKTTVLKSLQNDFPVHVLSIDTLVQEAIQAFHERQKSGKTPPTQEDDKRDPVVNQEKVSKTQDKNVLAVSPVPGDRTSQKEGVKINEFEQFRSSDSFLSLSMRAQLGAKSELMLRRGKSIPDILLVSILVNAIKEIPVDQSWVLDGFPITLNQAKLLEEALTGYKRKFLQLKKKKEQMPTLALDPSTSTEVSLLPSALDFVILLDISDNSSLARTNDIIAKEISHEISHENVGRPGTGTSQDNKSEDRNLRDHIQHRIVGFLDNWPLLEEWFTQPKNILTKVNAEIDEALLCQKVKEIFATETVNKKIKVEKTLEEKETEKKAGAPPAEPPAMSPPLSSEAEKDKELHQAKTPGKGKTQSVSPKGKAQGGKVSVKKSPVGSAEVSPTPTAPPPPKAGTEEWVYVNEPIPEELPSFLVPYWELIEKSYINHIKTVLRHLRERQHNVLSYLYETRTSFQEFLRRPDHKQDFVSQWQADFNSVPEDLWEDEETKAELHQRVNDLRDRLWDICEARKEEAEQERLDIINESWLQDSIGITMNHFFSLMQAEVNRFQDTKRLLQDYYRAMESKIPLEDSKKFTRVPLVQLDGKEISESQLRIPLVPRISNSPENSAVKPKVGTFLKGRSDPPLEVLEANFEIDEKILLDTWQQASLAISNMVAAEVHQRLTEEEKEPPQLDSKEKSPQSGANKKAKKEKEAPKKKKTDKKGKGKSSPVAEVSPVTVTPEEMAEMEKRNELRLRIKEEHLAALQTEEQAAQFRLELIKLKALSVLEDLVTKVIDVYRLMEKWLGKRYLNEMASIQKLTELARYHIETATKIQNEIYLSQEDFYINGDIKVFPDPSPPTRPPPVEREENGTLTIEQLDNLRDQFLDMAPKGIIGNKAFSDILLDLITLNLGTNNFPSSWMHLSQLDLQEITSLLTVNTEFVDWRKFLMVTAMPWPMALEDELLDTLQRFKALDEAQTGTITYEQYKQAGLWFSGDEDIKIPENPLEPLPFNRQEHLIEFFFRLFADCEKEPPQLDYTQMLLYFACHPDTLEGVYRALSVAVGTHIFRQVETPMLMAEKTSISTVSPIEEFPETEESSAKEDRELKEEKDDQKEEEIPENANTEKISMETLLKVFGGGNEVLDANRFASYLKSENIYAENFIKTFQDLGARNLEPIAVNILLKHPYIQDLIANYVDYKFPDIKMILQRSEHAQGSDGERSPSRLTDEKK
uniprot
proteins
function
FUNCTION: Required for correct axoneme development in spermatozoa (PubMed:21715716, PubMed:28619825). Important for normal development of the manchette and sperm head morphology (PubMed:28619825). Essential for male fertility (PubMed:21715716, PubMed:28619825, PubMed:31942643). Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis (PubMed:28619825). Plays a role in bone growth where it seems to be required for normal osteoblast differentiation (PubMed:29339787). Required for normal beat frequency of tracheal epithelial cilia and oviduct cilia (PubMed:31942643). {ECO:0000269|PubMed:21715716, ECO:0000269|PubMed:28619825, ECO:0000269|PubMed:29339787, ECO:0000269|PubMed:31942643}.
uniprot
proteins
mass_dalton
197972
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19889948
uniprot
proteins
pubmed
21715716
uniprot
proteins
pubmed
28619825
uniprot
proteins
pubmed
29339787
uniprot
proteins
pubmed
31942643
uniprot
proteins
sequence_length
1724
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9C093}. Cytoplasm, cytoskeleton, flagellum basal body {ECO:0000269|PubMed:19889948}. Cytoplasm {ECO:0000269|PubMed:19889948}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19889948, ECO:0000269|PubMed:28619825}. Golgi apparatus {ECO:0000269|PubMed:19889948}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q9C093}. Note=Shows dynamic localization in developing spermatozoa (PubMed:19889948). Localizes to the manchette in step 10-12 elongating spermatids, where it is mainly found on the basal side below the perinuclear ring (PubMed:19889948, PubMed:28619825). Detected in the basal body and neck area of step 13-14 spermatids (PubMed:19889948). Localizes to the midpiece of the sperm tail in step 15-16 spermatids (PubMed:19889948). During the epididymal transport of spermatozoa, expression in the sperm tail reduces and becomes concentrated at the distal part of the midpiece (PubMed:19889948). Detected in the Golgi apparatus of late spermatocytes and round spermatids (PubMed:19889948). Detected in the cytoplasm of Sertoli cells (PubMed:19889948). Detected in the axoneme of ciliated respiratory epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q9C093, ECO:0000269|PubMed:19889948, ECO:0000269|PubMed:28619825}.
uniprot
proteins