Lrrc8b
entrez
433926
canonical
uniprot
Q5DU41
canonical
ensembl
ENSMUSG00000070639
resolver
ensp
ENSMUSP00000108327
resolver
genesymbol
Lrrc8b
resolver
genesymbol_syn
Kiaa0231
resolver
uniprot
B2RSI6
resolver
uniprot_entry
LRC8B_MOUSE
resolver
uniprot_sec
B2RSI6
resolver
amino_acid_sequence
MITLTELKCLADAQSSYHILKPWWDVFWYYITLIMLLVAVLAGALQLTQSRVLCCLPCKVEFDNQCAVPWDLLKGSENASSNSGLLLPLPLRIQNDLHRQQYSYIDAVCYEKQLHWFAKFFPYLVLLHTLIFAACSNFWLHYPSTSSRLEHFVSILHKCFDSPWTTRALSETVAEQSVRPLKLSKSKTLLSTSGGSADIDASKQSLPYPQPGLESPGIESPTSSVLDKKEGEQAKAIFEKVKRFRLHVEQRDIIYRVYLKQIIVKVILFVLIITYVPYFLSYITLEIDCSIDVQAFTGYKRYQCVYSLAEIFKVLASFYVILVMLYGLTSSYSLWWMLRSSLKQYSFEALREKSNYSDIPDVKNDFAFILHLADQYDPLYSKRFSIFLSEVSENKLKQINLNNEWTVERLKSKLVKNSQDKVELHLFMLNGLPDNVFELTEMEVLSLELIPEVKLPAAVAQLVNLRELHVYHSSLVVDHPALAFLEENLRILRLKFTEMGKIPRWVFHLKNLKELYLSGCVLPEQLSSLHLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSLDNEGSKLVVLNNLKKMVNLKSLELLSCDLERIPHSIFSLNNLHELDLKENNLKTVEEIISFQHLPSLSCLKLWHNNIAYIPAQIGALSNLEQLFLGHNNIESLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLTNLQYFAVTNNNIEMLPDGLFQCKKLQCLLLGRNSLTDLSPLVGELSNLTHLELTGNYLETLPVELEGCQSLKRSCLIVEDSLLNSLPLPVAERLQTCLDKC
uniprot
proteins
function
FUNCTION: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:36522427). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:36522427). {ECO:0000250|UniProtKB:Q6P9F7, ECO:0000269|PubMed:36522427}.
uniprot
proteins
mass_dalton
92186
uniprot
proteins
protein_family
LRRC8 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24782309
uniprot
proteins
pubmed
36522427
uniprot
proteins
sequence_length
803
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6P9F7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q6P9F7}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q6P9F7}. Note=In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum. Requires LRRC8A for expression at the cell membrane. {ECO:0000250|UniProtKB:Q6P9F7}.
uniprot
proteins
transmembrane_region
TRANSMEM 26..46; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 120..140; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 262..282; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 308..328; /note="Helical; Name=4"; /evidence="ECO:0000255
uniprot
proteins