Q9ESV1
uniprot
Q9ESV1
canonical
amino_acid_sequence
MADIANYKDAASNRHLRFKLQSLSRRLDELEEATKNLQKAEDELLDLQDKVIQAEGSNSSMLAEIEVLRQRVLKIEGKDEEIKRAEDLCHTMKEKLEEEENLTRELKSEIDRLQKRMADLEKLEEALSRSKNECSQLCLSLNEERNLTKKISSELEMLRVKVKELESSEDRLEKTEQSLVSELEKLKSLTLSFVNERKYLNEKEKENEKLIKELTQKLEQNKKINRDHMRNASTFLERNDLRIEDGISSTLPSKESRRKGSLDYLKQVENETRDKSENEKNRNQEDNKVKDLNQEIEKLKTQIKHFESLEEELKKMRAKNNDLQDNYLTELNKNRSLASQLEEVKLQVKKQKELGNGDIEGEDAFLLGRGRHERTKLKGHGGEVSVSKHTSREQSPQHKRERLRNRGFALNDEHCSLSNKQVSSPAFTNKRAAKASNMGVGPDSGTQETKRTEDRLAPGSSQSEGKKGREQPSVLSRYPPAAQDHTKVWRGNPKPGTESGLKGKVEKTTRTFSDSAHGSVPNDVVGKGDKTSDFSSEAHCGKRGQVPGHASQVTQVAESGCSKAIGALASSQRASSEGLSKGKKAANGLETDANFPHSKAPILSKYPYSSRSQENILQGFSVPNKEGVDHSVAVVMEDSSQHEALRCRVIKSSGREKPDSDDDLDIESLVTAKLVNTTITPEPEPKLQPNSREKVKSRGGTRTPLFENDKNAAVENDSAKSMRSSSNAVEFPDANCAGVKNQRPFSPREALRSRAIIKPVIIDKDVKKIMGGSGTEVVLEKQKSTPKSVTSKVTSSITIYPSDSSGPRAVPTEAPRERHTSTSNIQVGPPELTSVSNHISSPLELSIHKHDITLQLTEAERVGDGSPKNRAETVVSRSSILIKPSDSVERNSHAFPAETIRWKSHSTSSEVASSDTRHITVRNAWKSKRDLKCSEDPPTRIGRNVEATNAYTQRSSTDFLELEQPRSHPPEQGTRKVGNSGDAPELSSRRTQSSLTASEVLTRRNRIGDAVTAASWNHSSNVVSLTFLPSALICLTEDLGNTEGWEMLNLR
uniprot
proteins
function
FUNCTION: F-actin cross-linking protein (By similarity). Stabilizes actin and acts as a negative regulator of primary cilium formation (By similarity). Positively regulates the phosphorylation of both myosin II and protein phosphatase 1 regulatory subunit PPP1R12A/MYPT1 and promotes the assembly of myosin II stacks within actin stress fibers (By similarity). Inhibits the phosphorylation of myosin light chain MYL9 by DAPK3 and suppresses the constriction velocity of the contractile ring during cytokinesis (By similarity). Binds to microtubules and promotes epithelial cell apical constriction by up-regulating levels of diphosphorylated myosin light chain (MLC) through microtubule-dependent inhibition of MLC dephosphorylation by myosin phosphatase (By similarity). Involved in regulation of cell migration, nuclear size and centriole number, probably through regulation of the actin cytoskeleton (By similarity). Component of the CERF-1 and CERF-5 chromatin remodeling complexes in embryonic stem cells where it acts to stabilize the complexes (By similarity). Plays a role in embryonic brain and cardiovascular development (By similarity). {ECO:0000250|UniProtKB:Q86V48, ECO:0000250|UniProtKB:Q8R4U7}.
uniprot
proteins
mass_dalton
117176
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8812416
uniprot
proteins
sequence_length
1051
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q86V48}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q86V48}. Midbody {ECO:0000250|UniProtKB:Q86V48}. Chromosome, centromere {ECO:0000250|UniProtKB:Q86V48}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q86V48}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000250|UniProtKB:Q86V48}. Nucleus {ECO:0000269|PubMed:8812416}. Cell projection, dendrite {ECO:0000269|PubMed:8812416}. Perikaryon {ECO:0000269|PubMed:8812416}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q8R4U7}. Note=Localizes to the proximal end of basal bodies (By similarity). During mitosis, localizes at the inner centromere in metaphase, at the central spindle in anaphase, and at the midbody in telophase (By similarity). Central spindle localization requires KIF20A while centromere localization requires the kinase activity of the chromosomal passenger complex (By similarity). {ECO:0000250|UniProtKB:Q86V48, ECO:0000269|PubMed:8812416}.
uniprot
proteins