COPS6
entrez
10980
canonical
uniprot
Q7L5N1
canonical
ensembl
ENSG00000168090
resolver
ensp
ENSP00000304102
resolver
ensp
ENSP00000578096
resolver
ensp
ENSP00000578097
resolver
enst
ENST00000303904
resolver
enst
ENST00000908037
resolver
enst
ENST00000908038
resolver
genesymbol
COPS6
resolver
genesymbol_syn
CSN6
resolver
genesymbol_syn
HVIP
resolver
hgnc
HGNC:21749
resolver
uniprot
A4D2A3
resolver
uniprot
O15387
resolver
uniprot_entry
CSN6_HUMAN
resolver
uniprot_sec
A4D2A3
resolver
uniprot_sec
O15387
resolver
amino_acid_sequence
MAAAAAAAAATNGTGGSSGMEVDAAVVPSVMACGVTGSVSVALHPLVILNISDHWIRMRSQEGRPVQVIGALIGKQEGRNIEVMNSFELLSHTVEEKIIIDKEYYYTKEEQFKQVFKELEFLGWYTTGGPPDPSDIHVHKQVCEIIESPLFLKLNPMTKHTDLPVSVFESVIDIINGEATMLFAELTYTLATEEAERIGVDHVARMTATGSGENSTVAEHLIAQHSAIKMLHSRVKLILEYVKASEAGEVPFNHEILREAYALCHCLPVLSTDKFKTDFYDQCNDVGLMAYLGTITKTCNTMNQFVNKFNVLYDRQGIGRRMRGLFF
uniprot
proteins
function
FUNCTION: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity. Stabilizes COP1 through reducing COP1 auto-ubiquitination and decelerating COP1 turnover rate, hence regulates the ubiquitination of COP1 targets. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:21625211, ECO:0000269|PubMed:9535219}.
uniprot
proteins
mass_dalton
36163
uniprot
proteins
protein_family
CSN6 subfamily
uniprot
proteins
protein_family
Peptidase M67A family
uniprot
proteins
pubmed
11285227
uniprot
proteins
pubmed
11337588
uniprot
proteins
pubmed
12220626
uniprot
proteins
pubmed
12237292
uniprot
proteins
pubmed
12628923
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12732143
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18850735
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21625211
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26030138
uniprot
proteins
pubmed
26456823
uniprot
proteins
pubmed
8195203
uniprot
proteins
pubmed
9341143
uniprot
proteins
pubmed
9520381
uniprot
proteins
pubmed
9535219
uniprot
proteins
sequence_length
327
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9535219}. Cytoplasm {ECO:0000269|PubMed:9535219}.; SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:9520381}. Note=(Microbial infection) The interaction with HIV-1 Vpr protein possibly leads its translocation to a perinuclear region. {ECO:0000269|PubMed:9520381}.
uniprot
proteins