Racgap1
entrez
26934
canonical
uniprot
Q9WVM1
canonical
ensembl
ENSMUSG00000023015
resolver
ensp
ENSMUSP00000023756
resolver
ensp
ENSMUSP00000126417
resolver
ensp
ENSMUSP00000256317
resolver
ensp
ENSMUSP00000338084
resolver
enst
ENSMUST00000023756
resolver
enst
ENSMUST00000171702
resolver
genesymbol
Racgap1
resolver
genesymbol_syn
Mgcracgap
resolver
uniprot
Q3THR5
resolver
uniprot
Q3TI41
resolver
uniprot
Q3TM81
resolver
uniprot_entry
RGAP1_MOUSE
resolver
uniprot_sec
Q3THR5
resolver
uniprot_sec
Q3TI41
resolver
uniprot_sec
Q3TM81
resolver
amino_acid_sequence
MDTTMVNLWTLFEQLVRRMEIINEGNESIEFIQVVKDFEDFRKKYQRTNQELEKFKDLLLKAETGRSALDVKLKHARNQVDVEIKRRQRAEAECAKLEQQIQLIRDILMCDTSGSIQLSEEQKSALAFLNRGQASSGHAGNNRLSTIDESGSILSDISFDKTDESLDWDSSLVKNFKMKKREKRRSNSRQFIDGPPGPVKKTCSIGSTVDQANESIVAKTTVTVPSDGGPIEAVSTIETLPSWTRSRGKSGPLQPVNSDSALNSRPLEPRTDTDNLGTPQNTGGMRLHDFVSKTVIKPESCVPCGKRIKFGKLSLKCRDCRLVSHPECRDRCPLPCIPPLVGTPVKIGEGMLADFVSQASPMIPAIVVSCVNEIEQRGLTEAGLYRISGCDRTVKELKEKFLKVKTVPLLSKVDDIHVICSLLKDFLRNLKEPLLTFWLSKAFMEAAEITDEDNSTAAMYQAVSELPQANRDTLAFLMIHLQRVSQSPDTKMDIANLAKVFGPTIVAHTVPNPDPVTMFQDIKRQLKVVERLLSLPLEYWNQFMMVDQENIDSQRGNGNSTPRTPDVKVSLLGPVTTPEFQLVKTPLSSSLSQRLYNLSKSTPRFGNKSKSATNLGQQGKFFPAPYLK
uniprot
proteins
function
FUNCTION: Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Sequentially binds to ECT2 and RAB11FIP3 which regulates cleavage furrow ingression and abscission during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Has a critical role in erythropoiesis (By similarity). Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells. {ECO:0000250|UniProtKB:Q9H0H5, ECO:0000269|PubMed:10235109, ECO:0000269|PubMed:10493933, ECO:0000269|PubMed:10979956, ECO:0000269|PubMed:11287179}.
uniprot
proteins
mass_dalton
70158
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at multiple sites in the midbody during cytokinesis (By similarity). Phosphorylation by AURKB on Ser-388 at the midbody is, at least in part, responsible for exerting its latent GAP activity towards RhoA (By similarity). Phosphorylation on multiple serine residues by PLK1 enhances its association with ECT2 and is critical for cleavage furrow formation (By similarity). Phosphorylation on Ser-165 plays a major role in mediating interaction with ECT2 (By similarity). Phosphorylation on Ser-158 does not appear to contribute to binding to ECT2 (By similarity). {ECO:0000250|UniProtKB:Q9H0H5}.
uniprot
proteins
pubmed
10235109
uniprot
proteins
pubmed
10493933
uniprot
proteins
pubmed
10979956
uniprot
proteins
pubmed
11287179
uniprot
proteins
pubmed
12590651
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
628
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12590651}. Cytoplasm {ECO:0000269|PubMed:12590651}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:12590651}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:12590651}. Cleavage furrow {ECO:0000250|UniProtKB:Q9H0H5}. Midbody, Midbody ring {ECO:0000250|UniProtKB:Q9H0H5}. Cell membrane {ECO:0000250|UniProtKB:Q9H0H5}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9H0H5}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9H0H5}. Midbody {ECO:0000250|UniProtKB:Q9H0H5}. Note=During interphase, localized to the nucleus and cytoplasm along with microtubules, in anaphase, is redistributed to the central spindle and, in telophase and cytokinesis, to the midbody ring, also called Flemming body. Colocalizes with RHOA at the myosin contractile ring during cytokinesis. Colocalizes with ECT2 to the mitotic spindles during anaphase/metaphase, the cleavage furrow during telophase and at the midbody at the end of cytokinesis. Colocalizes with Cdc42 to spindle microtubules from prometaphase to telophase (By similarity). Colocalizes with RND2 in Golgi-derived proacrosomal vesicles and the acrosome. Localizes to the midbody in a KIF23 and PRC1-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q9H0H5}.
uniprot
proteins