ADRA2B
entrez
151
canonical
uniprot
P18089
canonical
ensembl
ENSG00000274286
resolver
ensp
ENSP00000480573
resolver
enst
ENST00000620793
resolver
genesymbol
ADRA2B
resolver
genesymbol_syn
ADRA2L1
resolver
genesymbol_syn
ADRA2RL1
resolver
hgnc
HGNC:282
resolver
uniprot
A2RUS0
resolver
uniprot
Q4TUH9
resolver
uniprot
Q53RF2
resolver
uniprot
Q9BZK0
resolver
uniprot_entry
ADA2B_HUMAN
resolver
uniprot_sec
A2RUS0
resolver
uniprot_sec
Q4TUH9
resolver
uniprot_sec
Q53RF2
resolver
uniprot_sec
Q9BZK0
resolver
amino_acid_sequence
MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASVASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEEEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRPWTQTAW
uniprot
proteins
disease_involvement
DISEASE: Epilepsy, familial adult myoclonic, 2 (FAME2) [MIM:607876]: A form of familial myoclonic epilepsy, a neurologic disorder characterized by cortical hand tremors, myoclonic jerks and occasional generalized or focal seizures with a non-progressive or very slowly progressive disease course. Usually, myoclonic tremor is the presenting symptom, characterized by tremulous finger movements and myoclonic jerks of the limbs increased by action and posture. In a minority of patients, seizures are the presenting symptom. Some patients exhibit mild cognitive impairment. FAME2 inheritance is autosomal dominant. {ECO:0000269|PubMed:24114805}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression (PubMed:11056163, PubMed:2164221, PubMed:2172775, PubMed:23105096, PubMed:26811329). Control a variety of physiological processes, such as regulation of blood pressure, lipolysis and insulin release (PubMed:2164221). The rank order of potency for agonists of ADRA2B is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol (PubMed:2164221, PubMed:2172775). {ECO:0000269|PubMed:11056163, ECO:0000269|PubMed:2164221, ECO:0000269|PubMed:2172775, ECO:0000269|PubMed:23105096, ECO:0000269|PubMed:26811329}.
uniprot
proteins
mass_dalton
49954
uniprot
proteins
protein_family
ADRA2B sub-subfamily
uniprot
proteins
protein_family
Adrenergic receptor subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11056163
uniprot
proteins
pubmed
15037199
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
2164221
uniprot
proteins
pubmed
2172775
uniprot
proteins
pubmed
2173582
uniprot
proteins
pubmed
23105096
uniprot
proteins
pubmed
24114805
uniprot
proteins
pubmed
26811329
uniprot
proteins
pubmed
27901063
uniprot
proteins
pubmed
29069590
uniprot
proteins
pubmed
32152538
uniprot
proteins
sequence_length
450
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23105096, ECO:0000269|PubMed:26811329, ECO:0000269|PubMed:27901063, ECO:0000269|PubMed:29069590}; Multi-pass membrane protein {ECO:0000269|PubMed:23105096, ECO:0000269|PubMed:32152538}. Note=Interaction with RAB26, GGA1, GGA2 and GGA3 mediates transport from the Golgi to the cell membrane. {ECO:0000269|PubMed:23105096, ECO:0000269|PubMed:26811329, ECO:0000269|PubMed:27901063}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..35; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:32152538, ECO:0007744|PDB:6K41"; TRANSMEM 49..74; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:32152538, ECO:0007744|PDB:6K41"; TRANSMEM 86..108; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:32152538, ECO:0007744|PDB:6K41"; TRANSMEM 130..148; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:32152538, ECO:0007744|PDB:6K41"; TRANSMEM 171..193; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:32152538, ECO:0007744|PDB:6K41"; TRANSMEM 373..393; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:32152538, ECO:0007744|PDB:6K41"; TRANSMEM 408..428; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:32152538, ECO:0007744|PDB:6K41
uniprot
proteins