Ivd
entrez
56357
canonical
uniprot
Q9JHI5
canonical
ensembl
ENSMUSG00000027332
resolver
ensp
ENSMUSP00000028807
resolver
ensp
ENSMUSP00000173936
resolver
ensp
ENSMUSP00000332410
resolver
enst
ENSMUST00000028807
resolver
genesymbol
Ivd
resolver
uniprot
Q9CYI3
resolver
uniprot
Q9DBD7
resolver
uniprot_entry
IVD_MOUSE
resolver
uniprot_sec
Q9CYI3
resolver
uniprot_sec
Q9DBD7
resolver
amino_acid_sequence
MATAIRLLGRRVSSWRLRPSPSPLAVPRRAHSILPVDDDINGLNEEQKQLRHTISKFLQENLAPKAQEIDQTNDFKNLREFWKQLGSLGVLGITAPVQYGGSGLGYLEHVLVMEEISRASGAVGLSYGAHSNLCVNQIVRNGNEAQKEKYLPKLISGEFIGALAMSEPNAGSDVVSMKLKAEKKGDHYVLNGNKFWITNGPDADILVVYAKTDLTAVPASRGITAFIVEKGMPGFSTSKKLDKLGMRGSNTCELVFEDCKVPAANVLSQESKGVYVLMSGLDLERLVLAGGPLGIMQAVLDHTIPYLHVREAFGQKIGQFQLMQGKMADMYTRLMASRQYVYNVAKACDEGHIIPKDCAGVILYAAECATQVALDGIQCLGGNGYINDFPMGRFLRDAKLYEIGAGTSEVRRLVIGRAFNADFR
uniprot
proteins
ec_number
1.3.8.1
uniprot
proteins
ec_number
1.3.8.4
uniprot
proteins
function
FUNCTION: A mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism, where isovaleryl-CoA (3-methylbutanoyl-CoA) is metabolized to 3-methylbut-2-enoyl-CoA. To a lesser extent, it also participates in the first step in fatty acid beta-oxidation, in which it catalyzes the proR-proR stereospecific alpha,beta-dehydrogenation of other saturated short-chain acyl-CoA thioesters such as pentanoyl-CoA, hexanoyl-CoA and butanoyl-CoA, using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor. {ECO:0000250|UniProtKB:P26440}.
uniprot
proteins
mass_dalton
46325
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 1/3.
uniprot
proteins
post_translational_modification
PTM: Acetylation of Lys-76 is observed in liver mitochondria from fasted mice but not from fed mice.
uniprot
proteins
protein_family
Acyl-CoA dehydrogenase family
uniprot
proteins
pubmed
11404023
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
424
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:P12007}.
uniprot
proteins