Mapre2
entrez
679221
canonical
uniprot
Q3B8Q0
canonical
ensembl
ENSRNOG00000049681
resolver
ensembl
ENSRNOG00055018323
resolver
ensembl
ENSRNOG00060012062
resolver
ensembl
ENSRNOG00065015205
resolver
ensp
ENSRNOP00000065460
resolver
ensp
ENSRNOP00000065698
resolver
ensp
ENSRNOP00000111294
resolver
ensp
ENSRNOP00055025073
resolver
ensp
ENSRNOP00060016134
resolver
ensp
ENSRNOP00065019765
resolver
enst
ENSRNOT00000071364
resolver
enst
ENSRNOT00000075444
resolver
enst
ENSRNOT00055031104
resolver
enst
ENSRNOT00060020480
resolver
enst
ENSRNOT00065025237
resolver
genesymbol
Mapre2
resolver
genesymbol_syn
AABR07031491.2
resolver
uniprot
M0R7M8
resolver
uniprot_entry
M0R7M8_RAT
resolver
uniprot_entry
MARE2_RAT
resolver
amino_acid_sequence
MPGPTQTLSPNGENNNDIIQDNGTIIPFRKHTVRGERSYSWGMAVNVYSTSITQETMSRHDIIAWVNDIVSLNYTKVEQLCSGAAYCQFMDMLFPGCISLKKVKFQAKLEHEYIHNFKLLQASFKRMNVDKVIPVEKLVKGRFQDNLDFIQWFKKFYDANYDGKEYDPVEARQGQDAIPPPDPGEQIFNLPKKSHHANSPTAGAAKSSPAAKPGSTPSRPSSAKRASSSGSASRSDKDLETQVIQLNEQVHSLKLALEGVEKERDFYFGKLREIELLCQEHGQENDDLVQRLMEVLYASDEQEGQTEEPEVEEQTHDQQPQQQEEY
uniprot
proteins
function
FUNCTION: Adapter protein that is involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. Therefore, ensures mitotic progression and genome stability (By similarity). Acts as a central regulator of microtubule reorganization in apico-basal epithelial differentiation (By similarity). Plays a role during oocyte meiosis by regulating microtubule dynamics (By similarity). Participates in neurite growth by interacting with plexin B3/PLXNB3 and microtubule reorganization during apico-basal epithelial differentiation. Also plays an essential role for cell migration and focal adhesion dynamics. Mechanistically, recruits HAX1 to microtubules in order to regulate focal adhesion dynamics (By similarity). {ECO:0000250|UniProtKB:Q15555}.
uniprot
proteins
mass_dalton
36988
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-235 by CK2 leading to enhanced cell adhesion. Phosphorylated by CDK1 and AURKB during mitosis reduces the binding affinity of MAPRE2 for microtubules. {ECO:0000250|UniProtKB:Q15555}.; PTM: Ubiquitinated in an ASB14-dependent manner; leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q8R001}.
uniprot
proteins
protein_family
MAPRE family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
326
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Associated with the microtubule network. Accumulates at the plus end of microtubules (By similarity). {ECO:0000250}.
uniprot
proteins