FSHR
entrez
2492
canonical
uniprot
P23945
canonical
ensembl
ENSG00000170820
resolver
ensp
ENSP00000306780
resolver
ensp
ENSP00000384708
resolver
genesymbol
FSHR
resolver
genesymbol_syn
LGR1
resolver
hgnc
HGNC:3969
resolver
uniprot
A0A0A0MSC5
resolver
uniprot
A0A1D5RMN4
resolver
uniprot
A8K947
resolver
uniprot
B4DXB5
resolver
uniprot
G5CBS7
resolver
uniprot
G5E967
resolver
uniprot
J3KQ00
resolver
uniprot
Q05AH0
resolver
uniprot
Q16225
resolver
uniprot
Q4QRJ3
resolver
uniprot
Q4ZFZ2
resolver
uniprot
Q53RW2
resolver
uniprot_entry
B4DXB5_HUMAN
resolver
uniprot_entry
FSHR_HUMAN
resolver
uniprot_sec
A0A0A0MSC5
resolver
uniprot_sec
A0A1D5RMN4
resolver
uniprot_sec
A8K947
resolver
uniprot_sec
G5CBS7
resolver
uniprot_sec
G5E967
resolver
uniprot_sec
J3KQ00
resolver
uniprot_sec
Q05AH0
resolver
uniprot_sec
Q16225
resolver
uniprot_sec
Q4QRJ3
resolver
uniprot_sec
Q4ZFZ2
resolver
uniprot_sec
Q53RW2
resolver
amino_acid_sequence
MALLLVSLLAFLSLGSGCHHRICHCSNRVFLCQESKVTEIPSDLPRNAIELRFVLTKLRVIQKGAFSGFGDLEKIEISQNDVLEVIEADVFSNLPKLHEIRIEKANNLLYINPEAFQNLPNLQYLLISNTGIKHLPDVHKIHSLQKVLLDIQDNINIHTIERNSFVGLSFESVILWLNKNGIQEIHNCAFNGTQLDELNLSDNNNLEELPNDVFHGASGPVILDISRTRIHSLPSYGLENLKKLRARSTYNLKKLPTLEKLVALMEASLTYPSHCCAFANWRRQISELHPICNKSILRQEVDYMTQARGQRSSLAEDNESSYSRGFDMTYTEFDYDLCNEVVDVTCSPKPDAFNPCEDIMGYNILRVLIWFISILAITGNIIVLVILTTSQYKLTVPRFLMCNLAFADLCIGIYLLLIASVDIHTKSQYHNYAIDWQTGAGCDAAGFFTVFASELSVYTLTAITLERWHTITHAMQLDCKVQLRHAASVMVMGWIFAFAAALFPIFGISSYMKVSICLPMDIDSPLSQLYVMSLLVLNVLAFVVICGCYIHIYLTVRNPNIVSSSSDTRIAKRMAMLIFTDFLCMAPISFFAISASLKVPLITVSKAKILLVLFHPINSCANPFLYAIFTKNFRRDFFILLSKCGCYEMQAQIYRTETSSTVHNTHPRNGHCSSAPRVTSGSTYILVPLSHLAQN
uniprot
proteins
disease_involvement
DISEASE: Ovarian dysgenesis 1 (ODG1) [MIM:233300]: An autosomal recessive disease characterized by primary amenorrhea, variable development of secondary sex characteristics, poorly developed streak ovaries, and high serum levels of follicle-stimulating hormone (FSH) and luteinizing hormone (LH). {ECO:0000269|PubMed:10551778, ECO:0000269|PubMed:11889179, ECO:0000269|PubMed:12571157, ECO:0000269|PubMed:12915623, ECO:0000269|PubMed:7553856, ECO:0000269|PubMed:9769327, ECO:0000269|PubMed:9851774}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Ovarian hyperstimulation syndrome (OHSS) [MIM:608115]: Disorder which occurs either spontaneously or most often as an iatrogenic complication of ovarian stimulation treatments for in vitro fertilization. The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration. Pathologic features of this syndrome include the presence of multiple serous and hemorrhagic follicular cysts lined by luteinized cells, a condition called hyperreactio luteinalis. {ECO:0000269|PubMed:12930927, ECO:0000269|PubMed:12930928, ECO:0000269|PubMed:15080154, ECO:0000269|PubMed:16278261, ECO:0000269|PubMed:17721928, ECO:0000269|PubMed:24058690, ECO:0000269|PubMed:25581598}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for follitropin, the follicle-stimulating hormone (PubMed:11847099, PubMed:24058690, PubMed:24692546). Mediates FSH signaling through cAMP/protein kinase A (PKA) and phosphatidylinositol-3 kinase (PI3K)/protein kinase B (AKT) pathways to regulate ovarian follicular development and steroidogenesis (PubMed:24058690). Has diverse extragonadal functions: signals via a GNAI2-coupled FSHR on osteoclasts and their precursors, resulting in activation of MEK/ERK, NF-kappa-B, and AKT pathways and thus increases osteoclastogenesis and bone resorption (By similarity). Regulates glucose-stimulated insulin secretion in pancreatic beta-cells in a bell curve manner, with moderate FSH levels promoting insulin secretion via Galphas/cAMP/PKA pathways while high FSH levels inhibit this effect through Galphai coupling (By similarity). In adipose tissue, inhibits thermogenesis by suppressing UCP1 expression and promotes lipogenesis via CREB/PPARgamma pathways (By similarity). Also affects hepatic cholesterol metabolism by increasing serum total and low-density-lipoprotein cholesterol (LDL-C) by inhibiting the expression of LDL receptor (LDLR) (PubMed:26583582). {ECO:0000250|UniProtKB:P35378, ECO:0000269|PubMed:11847099, ECO:0000269|PubMed:24058690, ECO:0000269|PubMed:24692546, ECO:0000269|PubMed:26583582}.
uniprot
proteins
mass_dalton
78238
uniprot
proteins
mutagenesis
MUTAGEN 273; /note="S->I: Enhanced interaction with FSH."; /evidence="ECO:0000269|PubMed:36720854"; MUTAGEN 330; /note="Y->F: No change in intracellular cAMP accumulation."; /evidence="ECO:0000269|PubMed:11847099"; MUTAGEN 335; /note="Y->F: Reduces intracellular cAMP accumulation."; /evidence="ECO:0000269|PubMed:11847099"; MUTAGEN 335; /note="Y->G: More than 10-fold reduction of FSH activation potency."; /evidence="ECO:0000269|PubMed:36720854"; MUTAGEN 615; /note="H->Y: About 4-fold reduction of FSH activation potency."; /evidence="ECO:0000269|PubMed:36720854
uniprot
proteins
post_translational_modification
PTM: Sulfated. {ECO:0000269|PubMed:11847099}.; PTM: N-glycosylated; indirectly required for FSH-binding, possibly via a conformational change that allows high affinity binding of hormone. {ECO:0000250|UniProtKB:P20395}.
uniprot
proteins
protein_family
FSH/LSH/TSH subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10391209
uniprot
proteins
pubmed
10551778
uniprot
proteins
pubmed
11847099
uniprot
proteins
pubmed
11872202
uniprot
proteins
pubmed
11889179
uniprot
proteins
pubmed
12059813
uniprot
proteins
pubmed
12571157
uniprot
proteins
pubmed
12915623
uniprot
proteins
pubmed
12930927
uniprot
proteins
pubmed
12930928
uniprot
proteins
pubmed
1301382
uniprot
proteins
pubmed
1322283
uniprot
proteins
pubmed
1359889
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15080154
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15662415
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16278261
uniprot
proteins
pubmed
17030088
uniprot
proteins
pubmed
1709010
uniprot
proteins
pubmed
17721928
uniprot
proteins
pubmed
24058690
uniprot
proteins
pubmed
24692546
uniprot
proteins
pubmed
25581598
uniprot
proteins
pubmed
26583582
uniprot
proteins
pubmed
36720854
uniprot
proteins
pubmed
7553856
uniprot
proteins
pubmed
7916967
uniprot
proteins
pubmed
7926278
uniprot
proteins
pubmed
8636335
uniprot
proteins
pubmed
8747461
uniprot
proteins
pubmed
9100567
uniprot
proteins
pubmed
9769327
uniprot
proteins
pubmed
9851774
uniprot
proteins
sequence_length
695
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11847099, ECO:0000269|PubMed:24692546}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 367..387; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 399..421; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 444..465; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 486..508; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 529..550; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 574..597; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 609..630; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins