TTYH2
entrez
94015
canonical
uniprot
Q9BSA4
canonical
ensembl
ENSG00000141540
resolver
ensp
ENSP00000269346
resolver
ensp
ENSP00000394576
resolver
ensp
ENSP00000433089
resolver
enst
ENST00000529107
resolver
genesymbol
TTYH2
resolver
genesymbol_syn
C17orf29
resolver
hgnc
HGNC:13877
resolver
uniprot
B3KX97
resolver
uniprot
B4DKD1
resolver
uniprot
F6SYS2
resolver
uniprot
Q3B7H8
resolver
uniprot
Q3B7R9
resolver
uniprot
Q6AWB4
resolver
uniprot
Q8NBB7
resolver
uniprot
Q96PK1
resolver
uniprot_entry
B4DKD1_HUMAN
resolver
uniprot_entry
F6SYS2_HUMAN
resolver
uniprot_entry
TTYH2_HUMAN
resolver
uniprot_sec
B3KX97
resolver
uniprot_sec
Q3B7H8
resolver
uniprot_sec
Q3B7R9
resolver
uniprot_sec
Q6AWB4
resolver
uniprot_sec
Q8NBB7
resolver
uniprot_sec
Q96PK1
resolver
amino_acid_sequence
MQAARVDYIAPWWVVWLHSVPHVGLRLQPVNSTFSPGDESYQESLLFLGLVAAVCLGLNLIFLVAYLVCACHCRRDDAVQTKQHHSCCITWTAVVAGLICCAAVGVGFYGNSETNDGAYQLMYSLDDANHTFSGIDALVSGTTQKMKVDLEQHLARLSEIFAARGDYLQTLKFIQQMAGSVVVQLSGLPVWREVTMELTKLSDQTGYVEYYRWLSYLLLFILDLVICLIACLGLAKRSKCLLASMLCCGALSLLLSWASLAADGSAAVATSDFCVAPDTFILNVTEGQISTEVTRYYLYCSQSGSSPFQQTLTTFQRALTTMQIQVAGLLQFAVPLFSTAEEDLLAIQLLLNSSESSLHQLTAMVDCRGLHKDYLDALAGICYDGLQGLLYLGLFSFLAALAFSTMICAGPRAWKHFTTRNRDYDDIDDDDPFNPQAWRMAAHSPPRGQLHSFCSYSSGLGSQTSLQPPAQTISNAPVSEYMNQAMLFGRNPRYENVPLIGRASPPPTYSPSMRATYLSVADEHLRHYGNQFPA
uniprot
proteins
function
FUNCTION: Calcium-independent, swelling-dependent volume-regulated anion channel (VRAC-swell) which plays a pivotal role in the process of regulatory volume decrease (RVD) in the brain through the efflux of anions like chloride and organic osmolytes like glutamate (By similarity). Probable large-conductance Ca(2+)-activated chloride channel (PubMed:15010458). {ECO:0000250|UniProtKB:Q3TH73, ECO:0000269|PubMed:15010458}.
uniprot
proteins
mass_dalton
58772
uniprot
proteins
mutagenesis
MUTAGEN 31; /note="N->Q: Loss of glycosylation. No effect on cell membrane localization, increased ubiquitination and significant decrease in protein levels; when associated with Q-129; Q-283 and Q-352."; /evidence="ECO:0000269|PubMed:18260827"; MUTAGEN 129; /note="N->Q: Loss of glycosylation. No effect on cell membrane localization, increased ubiquitination and significant decrease in protein levels; when associated with Q-31; Q-283 and Q-352."; /evidence="ECO:0000269|PubMed:18260827"; MUTAGEN 283; /note="N->Q: Loss of glycosylation. No effect on cell membrane localization, increased ubiquitination and significant decrease in protein levels; when associated with Q-31; Q-129 and Q-352."; /evidence="ECO:0000269|PubMed:18260827"; MUTAGEN 352; /note="N->Q: Loss of glycosylation. No effect on cell membrane localization, increased ubiquitination and significant decrease in protein levels; when associated with Q-31; Q-129 and Q-283."; /evidence="ECO:0000269|PubMed:18260827"; MUTAGEN 444; /note="S->A: No effect on interaction with NEDD4L and NEDD4L-mediated ubiquitination."; /evidence="ECO:0000269|PubMed:18577513"; MUTAGEN 504; /note="S->A: No effect on interaction with NEDD4L and NEDD4L-mediated ubiquitination."; /evidence="ECO:0000269|PubMed:18577513"; MUTAGEN 509; /note="Y->F: Loss of interaction with NEDD4L and almost complete loss of NEDD4L-mediated ubiquitination. A 3-fold increase in its expression in the cell membrane and a 1.5-fold increase in protein levels."; /evidence="ECO:0000269|PubMed:18577513"; MUTAGEN 510; /note="S->A: Reduced interaction with NEDD4L and reduced NEDD4L-mediated ubiquitination. A 2-fold increase in its expression in the cell membrane and a 1.5-fold increase in protein levels."; /evidence="ECO:0000269|PubMed:18577513
uniprot
proteins
post_translational_modification
PTM: N- Glycosylated. Contains high-mannose, hybrid and complex oligosaccharides. {ECO:0000269|PubMed:18260827}.; PTM: Ubiquitinated by NEDD4L, leading to its proteasomal degradation. {ECO:0000269|PubMed:18260827, ECO:0000269|PubMed:18577513}.
uniprot
proteins
protein_family
Tweety family
uniprot
proteins
pubmed
11597145
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15010458
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17569141
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18260827
uniprot
proteins
pubmed
18577513
uniprot
proteins
pubmed
34385445
uniprot
proteins
sequence_length
534
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18260827, ECO:0000269|PubMed:18577513, ECO:0000269|PubMed:34385445}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 45..65; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 88..108; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 214..234; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 241..261; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 389..409; /note="Helical; Name=5"; /evidence="ECO:0000255
uniprot
proteins