ST8SIA4
entrez
7903
canonical
uniprot
Q92187
canonical
ensembl
ENSG00000113532
resolver
ensp
ENSP00000231461
resolver
ensp
ENSP00000428914
resolver
ensp
ENSP00000551426
resolver
ensp
ENSP00000778201
resolver
genesymbol
ST8SIA4
resolver
genesymbol_syn
PST
resolver
genesymbol_syn
PST1
resolver
genesymbol_syn
SIAT8D
resolver
hgnc
HGNC:10871
resolver
uniprot
A8KA07
resolver
uniprot
G3V104
resolver
uniprot
Q8N1F4
resolver
uniprot
Q92693
resolver
uniprot_entry
SIA8D_HUMAN
resolver
uniprot_sec
A8KA07
resolver
uniprot_sec
G3V104
resolver
uniprot_sec
Q8N1F4
resolver
uniprot_sec
Q92693
resolver
amino_acid_sequence
MRSIRKRWTICTISLLLIFYKTKEIARTEEHQETQLIGDGELSLSRSLVNSSDKIIRKAGSSIFQHNVEGWKINSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTTGKCVKQ
uniprot
proteins
ec_number
2.4.3.-
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of a sialic acid from a CMP-linked sialic acid donor onto a terminal alpha-2,3-, alpha-2,6-, or alpha-2,8-linked sialic acid of an N-linked glycan protein acceptor through alpha-2,8-linkages (PubMed:10766765, PubMed:11279095, PubMed:28810663, PubMed:9774483). Therefore, participates in polysialic acid synthesis on various sialylated N-acetyllactosaminyl oligosaccharides, including NCAM1 N-glycans, FETUB N-glycans and AHSG (PubMed:10766765, PubMed:11279095, PubMed:28810663, PubMed:9774483). It is noteworthy that alpha-2,3-linked sialic acid is apparently a better acceptor than alpha-2,6-linked sialic acid (PubMed:9774483). {ECO:0000269|PubMed:10766765, ECO:0000269|PubMed:11279095, ECO:0000269|PubMed:28810663, ECO:0000269|PubMed:9774483}.
uniprot
proteins
mass_dalton
41295
uniprot
proteins
mutagenesis
MUTAGEN 142; /note="C->A: Loss of NCAM1 polysialylation activity. Loss of autopolysialylation. Loss of NCAM1 polysialylation activity; when associated with A-292. Loss of autopolysialylation; when associated with A-292."; /evidence="ECO:0000269|PubMed:11279095"; MUTAGEN 156; /note="C->A: Loss of NCAM1 polysialylation activity. Loss of autopolysialylation. Loss of NCAM1 polysialylation activity; when associated with A-356. Loss of autopolysialylation; when associated with A-356."; /evidence="ECO:0000269|PubMed:11279095"; MUTAGEN 169; /note="C->A: Reduces NCAM1 polysialylation activity. Loss of autopolysialylation."; /evidence="ECO:0000269|PubMed:11279095"; MUTAGEN 292; /note="C->A: Loss of NCAM1 polysialylation activity. Loss of autopolysialylation. Loss of NCAM1 polysialylation activity; when associated with A-142. Loss of autopolysialylation; when associated with A-142."; /evidence="ECO:0000269|PubMed:11279095"; MUTAGEN 356; /note="C->A: Loss of NCAM1 polysialylation activity. Loss of autopolysialylation. Loss of NCAM1 polysialylation activity; when associated with A-156. Loss of autopolysialylation; when associated with A-156."; /evidence="ECO:0000269|PubMed:11279095
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:10766765, ECO:0000269|PubMed:11279095, ECO:0000269|PubMed:28810663, ECO:0000269|PubMed:9774483}.
uniprot
proteins
post_translational_modification
PTM: Autopolysialylated. {ECO:0000269|PubMed:10766765, ECO:0000269|PubMed:9852130}.
uniprot
proteins
protein_family
Glycosyltransferase 29 family
uniprot
proteins
pubmed
10766765
uniprot
proteins
pubmed
11279095
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
28810663
uniprot
proteins
pubmed
30569872
uniprot
proteins
pubmed
7624364
uniprot
proteins
pubmed
9774483
uniprot
proteins
pubmed
9852130
uniprot
proteins
sequence_length
359
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:9852130}; Single-pass type II membrane protein {ECO:0000305}. Secreted {ECO:0000269|PubMed:9852130}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..20; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins