POLI
entrez
11201
canonical
uniprot
Q9UNA4
canonical
ensembl
ENSG00000101751
resolver
ensp
ENSP00000217800
resolver
ensp
ENSP00000385196
resolver
ensp
ENSP00000462664
resolver
ensp
ENSP00000462681
resolver
ensp
ENSP00000524709
resolver
ensp
ENSP00000611453
resolver
ensp
ENSP00000648529
resolver
enst
ENST00000406285
resolver
enst
ENST00000579434
resolver
enst
ENST00000579534
resolver
genesymbol
POLI
resolver
genesymbol_syn
RAD30B
resolver
hgnc
HGNC:9182
resolver
uniprot
J3KQ09
resolver
uniprot
J3KSW2
resolver
uniprot
Q8N590
resolver
uniprot
Q9H0S1
resolver
uniprot
Q9NYH6
resolver
uniprot_entry
J3KQ09_HUMAN
resolver
uniprot_entry
J3KSW2_HUMAN
resolver
uniprot_entry
POLI_HUMAN
resolver
uniprot_sec
Q8N590
resolver
uniprot_sec
Q9H0S1
resolver
uniprot_sec
Q9NYH6
resolver
amino_acid_sequence
MEKLGVEPEEEGGGDDDEEDAEAWAMELADVGAAASSQGVHDQVLPTPNASSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGFDENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLVGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGISVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELLASLLNRVCQDGRKPHTVRLIIRRYSSEKHYGRESRQCPIPSHVIQKLGTGNYDVMTPMVDILMKLFRNMVNVKMPFHLTLLSVCFCNLKALNTAKKGLIDYYLMPSLSTTSRSGKHSFKMKDTHMEDFPKDKETNRDFLPSGRIESTRTRESPLDTTNFSKEKDINEFPLCSLPEGVDQEVFKQLPVDIQEEILSGKSREKFQGKGSVSCPLHASRGVLSFFSKKQMQDIPINPRDHLSSSKQVSSVSPCEPGTSGFNSSSSSYMSSQKDYSYYLDNRLKDERISQGPKEPQGFHFTNSNPAVSAFHSFPNLQSEQLFSRNHTTDSHKQTVATDSHEGLTENREPDSVDEKITFPSDIDPQVFYELPEAVQKELLAEWKRAGSDFHIGHK
uniprot
proteins
ec_number
2.7.7.7
uniprot
proteins
function
FUNCTION: Error-prone DNA polymerase specifically involved in DNA repair (PubMed:11013228, PubMed:11387224). Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls (PubMed:11013228, PubMed:11387224, PubMed:14630940, PubMed:15199127, PubMed:20388628). Favors Hoogsteen base-pairing in the active site (PubMed:15254543). Inserts the correct base with high-fidelity opposite an adenosine template (PubMed:15254543). Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine (PubMed:11013228). May play a role in hypermutation of immunoglobulin genes (PubMed:12410315). Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity (PubMed:11251121, PubMed:14630940). {ECO:0000269|PubMed:11013228, ECO:0000269|PubMed:11251121, ECO:0000269|PubMed:11387224, ECO:0000269|PubMed:12410315, ECO:0000269|PubMed:14630940, ECO:0000269|PubMed:15199127, ECO:0000269|PubMed:15254543, ECO:0000269|PubMed:20388628}.
uniprot
proteins
mass_dalton
83006
uniprot
proteins
mutagenesis
MUTAGEN 1..25; /note="Missing: Small decrease in catalytic activity efficiency which is partially rescued by the presence of Mn(2+) instead Mg(2+)."; /evidence="ECO:0000269|PubMed:27555320
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated. Protein monoubiquitination prevents POLI binding to ubiquitin via the ubiquitin-binding motif 1 and ubiquitin-binding motif 2. {ECO:0000250|UniProtKB:Q6R3M4}.
uniprot
proteins
protein_family
DNA polymerase type-Y family
uniprot
proteins
pubmed
10458907
uniprot
proteins
pubmed
11013228
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
11251121
uniprot
proteins
pubmed
11387224
uniprot
proteins
pubmed
12410315
uniprot
proteins
pubmed
12606586
uniprot
proteins
pubmed
14630940
uniprot
proteins
pubmed
15199127
uniprot
proteins
pubmed
15254543
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
20388628
uniprot
proteins
pubmed
27555320
uniprot
proteins
sequence_length
740
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12606586}. Note=Binding to ubiquitin mediates localization to replication forks after UV-induced DNA damage. {ECO:0000250|UniProtKB:Q6R3M4}.
uniprot
proteins