TRMT61B
entrez
55006
canonical
uniprot
Q9BVS5
canonical
ensembl
ENSG00000171103
resolver
ensp
ENSP00000302801
resolver
ensp
ENSP00000389617
resolver
ensp
ENSP00000543425
resolver
ensp
ENSP00000543428
resolver
ensp
ENSP00000665522
resolver
ensp
ENSP00000665523
resolver
ensp
ENSP00000678789
resolver
ensp
ENSP00000678794
resolver
ensp
ENSP00000794760
resolver
enst
ENST00000306108
resolver
enst
ENST00000439947
resolver
genesymbol
TRMT61B
resolver
hgnc
HGNC:26070
resolver
uniprot
F8WDR2
resolver
uniprot
Q9H0Q9
resolver
uniprot
Q9NWS7
resolver
uniprot_entry
F8WDR2_HUMAN
resolver
uniprot_entry
TR61B_HUMAN
resolver
uniprot_sec
Q9H0Q9
resolver
uniprot_sec
Q9NWS7
resolver
amino_acid_sequence
MLMAWCRGPVLLCLRQGLGTNSFLHGLGQEPFEGARSLCCRSSPRDLRDGEREHEAAQRKAPGAESCPSLPLSISDIGTGCLSSLENLRLPTLREESSPRELEDSSGDQGRCGPTHQGSEDPSMLSQAQSATEVEERHVSPSCSTSRERPFQAGELILAETGEGETKFKKLFRLNNFGLLNSNWGAVPFGKIVGKFPGQILRSSFGKQYMLRRPALEDYVVLMKRGTAITFPKDINMILSMMDINPGDTVLEAGSGSGGMSLFLSKAVGSQGRVISFEVRKDHHDLAKKNYKHWRDSWKLSHVEEWPDNVDFIHKDISGATEDIKSLTFDAVALDMLNPHVTLPVFYPHLKHGGVCAVYVVNITQVIELLDGIRTCELALSCEKISEVIVRDWLVCLAKQKNGILAQKVESKINTDVQLDSQEKIGVKGELFQEDDHEESHSDFPYGSFPYVARPVHWQPGHTAFLVKLRKVKPQLN
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
ec_number
2.1.1.220
uniprot
proteins
function
FUNCTION: Methyltransferase that catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in various tRNAs in mitochondrion, including tRNA(Leu) (deciphering codons UUA or UUG), tRNA(Lys) and tRNA(Ser) (deciphering codons UCA, UCU, UCG or UCC) (PubMed:23097428). Catalyzes the formation of 1-methyladenosine at position 947 of mitochondrial 16S ribosomal RNA and this modification is most likely important for mitoribosomal structure and function (PubMed:27631568). In addition to tRNA N(1)-methyltransferase activity, also acts as a mRNA N(1)-methyltransferase by mediating methylation of adenosine residues at the N(1) position of MT-ND5 mRNA, leading to interfere with mitochondrial translation (PubMed:29107537). {ECO:0000269|PubMed:23097428, ECO:0000269|PubMed:27631568, ECO:0000269|PubMed:29107537}.
uniprot
proteins
mass_dalton
52965
uniprot
proteins
mutagenesis
MUTAGEN 335; /note="D->A: Loss of ability to catalyze the formation of 1-methyladenosine at position 947 of mitochondrial 16S ribosomal RNA."; /evidence="ECO:0000269|PubMed:27631568
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
TRM61 family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
23097428
uniprot
proteins
pubmed
27184847
uniprot
proteins
pubmed
27631568
uniprot
proteins
pubmed
29072297
uniprot
proteins
pubmed
29107537
uniprot
proteins
sequence_length
477
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:23097428, ECO:0000269|PubMed:27184847}.
uniprot
proteins