Serbp1
entrez
66870
canonical
uniprot
Q9CY58
canonical
ensembl
ENSMUSG00000036371
resolver
ensp
ENSMUSP00000039110
resolver
ensp
ENSMUSP00000144713
resolver
ensp
ENSMUSP00000144913
resolver
ensp
ENSMUSP00000145472
resolver
enst
ENSMUST00000203436
resolver
genesymbol
Serbp1
resolver
genesymbol_syn
Pairbp1
resolver
uniprot
A0A0N4SUK0
resolver
uniprot
Q3UEI6
resolver
uniprot
Q3UMP4
resolver
uniprot
Q8BHS2
resolver
uniprot
Q8BHU0
resolver
uniprot
Q91WP3
resolver
uniprot
Q9CSN0
resolver
uniprot
Q9DBY6
resolver
uniprot_entry
A0A0N4SUK0_MOUSE
resolver
uniprot_entry
Q3UEI6_MOUSE
resolver
uniprot_entry
Q3UMP4_MOUSE
resolver
uniprot_entry
SERB1_MOUSE
resolver
uniprot_sec
Q8BHS2
resolver
uniprot_sec
Q8BHU0
resolver
uniprot_sec
Q91WP3
resolver
uniprot_sec
Q9CSN0
resolver
uniprot_sec
Q9DBY6
resolver
amino_acid_sequence
MPGHLQEGFGCVVTNRFDQLFDDESDPFEVLKAAENKKKEAGGGGVGGPGAKSAAQAAAQTNSNAAGKQLRKESQKDRKNPLPPSVGVADKKEETQPPVALKKEGIRRVGRRPDQQLQGDGKLIDRRAERRPPRERRFEKPLEEKGEGGEFSVDRPIIERPIRGRGGLGRGRGGRGRGMGRGDGFDSRGKREFDRHSGSDRSSFSHYSGLKHEDKRGGSGSHNWGTVKDELTESPKYIQKQISYNCSDLDQSNVTEETPEGEEHPVADTENKENEVEEVKEEGPKEMTLDEWKAIQNKDRAKVEFNIRKPNEGADGQWKKGFVLHKSKSEEAHAEDSVMDHHFRKPANDITSQLEINFGDLGRPGRGGRGGRGGRGRGGRPNRGSRTDKSSASAPDVDDPEAFPALA
uniprot
proteins
function
FUNCTION: Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (PubMed:34815424). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (PubMed:34815424). May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay (By similarity). Seems to play a role in PML-nuclear bodies formation (By similarity). {ECO:0000250|UniProtKB:Q8NC51, ECO:0000269|PubMed:34815424}.
uniprot
proteins
mass_dalton
44714
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by MTOR inhibits SERBP1 and relieves ribosome hibernation. {ECO:0000250|UniProtKB:Q8NC51}.
uniprot
proteins
protein_family
SERBP1-HABP4 family
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
23894536
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
34815424
uniprot
proteins
sequence_length
407
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8NC51}. Nucleus {ECO:0000250|UniProtKB:Q8NC51}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8NC51}.
uniprot
proteins