Prrt2
entrez
361651
canonical
uniprot
D3ZFB6
canonical
ensembl
ENSRNOG00000029366
resolver
ensp
ENSRNOP00000050996
resolver
enst
ENSRNOT00000049044
resolver
genesymbol
Prrt2
resolver
uniprot_entry
PRRT2_RAT
resolver
amino_acid_sequence
MAASSSEVSEMKGVEDSSNTHSEGPRHSEEGMGPVQVVAENLDQPEALQSGPDTTAAPVDSGPKAELAPETTETPVETPETVQATDLSVNPGEDSKTCPSPKEACQEPASRPEVNREATAEQGAEQQSAAPPEPTSEQALQLNTQSDPQPTSQPPPKPPLQAEPPTQENPTTEVLTESTGEKQENGAVVPLQAGDGEEGPAPQPHSPPSTKTPPANGAPPRVLQKLVEEDRIGRAHGGHPGSPRGSLSRHPSSQLAGPGVEGGEGTQKPRDYIILAILSCFCPMWPVNIVAFAYAVMSRNSLQQGDVDGAQRLGRVAKLLSIVALVGGVLIIIASCVINLGVYK
uniprot
proteins
function
FUNCTION: As a component of the outer core of AMPAR complex, may be involved in synaptic transmission in the central nervous system. In hippocampal neurons, in presynaptic terminals, plays an important role in the final steps of neurotransmitter release, possibly by regulating Ca(2+)-sensing. In the cerebellum, may inhibit SNARE complex formation and down-regulate short-term facilitation. {ECO:0000250|UniProtKB:E9PUL5}.
uniprot
proteins
mass_dalton
35821
uniprot
proteins
protein_family
CD225/Dispanin family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22632720
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
26797119
uniprot
proteins
pubmed
27172900
uniprot
proteins
sequence_length
344
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27172900}; Single-pass membrane protein {ECO:0000250|UniProtKB:E9PUL5}. Presynaptic cell membrane {ECO:0000250|UniProtKB:E9PUL5}; Single-pass membrane protein {ECO:0000250|UniProtKB:E9PUL5}. Synapse {ECO:0000250|UniProtKB:E9PUL5}. Cell projection, axon {ECO:0000250|UniProtKB:Q7Z6L0}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:27172900}. Postsynaptic density membrane {ECO:0000269|PubMed:27172900}. Cell projection, dendritic spine {ECO:0000269|PubMed:27172900}.
uniprot
proteins
transmembrane_region
TRANSMEM 322..342; /note="Helical"; /evidence="ECO:0000250|UniProtKB:E9PUL5, ECO:0000255
uniprot
proteins