AFTPH
entrez
54812
canonical
uniprot
Q6ULP2
canonical
ensembl
ENSG00000119844
resolver
ensp
ENSP00000238856
resolver
ensp
ENSP00000387071
resolver
ensp
ENSP00000512229
resolver
ensp
ENSP00000512230
resolver
ensp
ENSP00000512231
resolver
ensp
ENSP00000512232
resolver
ensp
ENSP00000512233
resolver
ensp
ENSP00000550297
resolver
ensp
ENSP00000550299
resolver
ensp
ENSP00000612433
resolver
enst
ENST00000695865
resolver
enst
ENST00000695866
resolver
enst
ENST00000695867
resolver
enst
ENST00000695869
resolver
genesymbol
AFTPH
resolver
genesymbol_syn
AFTH
resolver
hgnc
HGNC:25951
resolver
uniprot
A0A8Q3SI61
resolver
uniprot
A0A8Q3SIA4
resolver
uniprot
A0A8Q3WKU6
resolver
uniprot
A0A8Q3WM48
resolver
uniprot
D6W5E9
resolver
uniprot
Q53GW0
resolver
uniprot
Q6ZM66
resolver
uniprot
Q86VW3
resolver
uniprot
Q8TCF3
resolver
uniprot
Q9H7E3
resolver
uniprot
Q9HAB9
resolver
uniprot
Q9NXS4
resolver
uniprot_entry
A0A8Q3SI61_HUMAN
resolver
uniprot_entry
A0A8Q3SIA4_HUMAN
resolver
uniprot_entry
A0A8Q3WKU6_HUMAN
resolver
uniprot_entry
A0A8Q3WM48_HUMAN
resolver
uniprot_entry
AFTIN_HUMAN
resolver
uniprot_entry
Q53GW0_HUMAN
resolver
uniprot_sec
D6W5E9
resolver
uniprot_sec
Q6ZM66
resolver
uniprot_sec
Q86VW3
resolver
uniprot_sec
Q8TCF3
resolver
uniprot_sec
Q9H7E3
resolver
uniprot_sec
Q9HAB9
resolver
uniprot_sec
Q9NXS4
resolver
amino_acid_sequence
MEPDIIRMYSSSPPPLDNGAEDDDDDEFGEFGGFSEVSPSGVGFVDFDTPDYTRPKEEFVPSNHFMPIHEFSENVDSLTSFKSIKNGNDKDITAELSAPVKGQSDVLLSTTSKEIISSEMLATSIDGMERPGNLNKVVEQRQNVGTLESFSPGDFRTNMNVVHQNKQLESCNGEKPPCLEILTNGFAVLETVNPQGTDDLDNVADSKGRKPLSTHSTEYNLDSVPSPAEEFADFATFSKKERIQLEEIECAVLNDREALTIRENNKINRVNELNSVKEVALGRSLDNKGDTDGEDQVCVSEISIVTNRGFSVEKQGLPTLQQDEFLQSGVQSKAWSLVDSADNSEAIRREQCKTEEKLDLLTSKCAHLCMDSVKTSDDEVGSPKEESRKFTNFQSPNIDPTEENDLDDSLSVKNGDSSNDFVTCNDINEDDFGDFGDFGSASGSTPPFVTGTQDSMSDATFEESSEHFPHFSEPGDDFGEFGDINAVSCQEETILTKSDLKQTSDNLSEECQLARKSSGTGTEPVAKLKNGQEGEIGHFDSVPNIQDDCNGFQDSDDFADFSSAGPSQVVDWNAFEDEQKDSCSWAAFGDQQATESHHRKEAWQSHRTDENIDTPGTPKTHSVPSATSKGAVASGHLQESATSVQTALLNRLERIFEACFPSILVPDAEEEVTSLKHLLETSTLPIKTREALPESGELLDVWTELQDIHDAHGLRYQWGGSHSNKKLLSSLGIDTRNILFTGNKKQPVIVPMYAAGLGMLEPTKEPLKPLSAAEKIASIGQTATMSPDMNTCTSDQFQESLPPVQFDWSSSGLTNPLDASGGSTLLNLDFFGPVDDSSSSSSTTIPGVDPELYELTTSKLEISTSSLKVTDAFARLMSTVEKTSTSTRKPKREEHLSEEAIKVIAGLPDLTFMHAKVLMFPATLTPSTSSQEKADG
uniprot
proteins
function
FUNCTION: Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025). {ECO:0000269|PubMed:15758025}.
uniprot
proteins
mass_dalton
102113
uniprot
proteins
mutagenesis
MUTAGEN 716..718; /note="YQW->SQS: Abolishes the interaction with CLTCL1/Clathrin."; /evidence="ECO:0000269|PubMed:15758025
uniprot
proteins
pubmed
14665628
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15758025
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
936
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14665628, ECO:0000269|PubMed:15758025}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:15758025}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:15758025}. Note=Co-localizes with AP1G1/AP-1 in the cytoplasm (PubMed:14665628, PubMed:15758025). Recruited to the perinuclear region by AP1G1/AP-1 (PubMed:15758025). {ECO:0000269|PubMed:14665628, ECO:0000269|PubMed:15758025}.
uniprot
proteins