Mia2
entrez
338320
canonical
uniprot
Q91ZV0
canonical
ensembl
ENSMUSG00000021000
resolver
ensp
ENSMUSP00000070572
resolver
ensp
ENSMUSP00000126538
resolver
ensp
ENSMUSP00000135001
resolver
ensp
ENSMUSP00000135100
resolver
ensp
ENSMUSP00000135245
resolver
ensp
ENSMUSP00000135251
resolver
ensp
ENSMUSP00000135390
resolver
ensp
ENSMUSP00000135440
resolver
ensp
ENSMUSP00000135618
resolver
ensp
ENSMUSP00000151482
resolver
ensp
ENSMUSP00000194117
resolver
enst
ENSMUST00000069430
resolver
enst
ENSMUST00000170992
resolver
enst
ENSMUST00000175912
resolver
enst
ENSMUST00000176322
resolver
enst
ENSMUST00000176464
resolver
enst
ENSMUST00000176892
resolver
enst
ENSMUST00000177162
resolver
enst
ENSMUST00000219140
resolver
genesymbol
Mia2
resolver
genesymbol_syn
Ctage5
resolver
uniprot
A0A1W2P711
resolver
uniprot
E9PY90
resolver
uniprot
E9Q3S2
resolver
uniprot
H3BJI6
resolver
uniprot
H3BJS0
resolver
uniprot
H3BK44
resolver
uniprot
H3BK48
resolver
uniprot
H3BKH2
resolver
uniprot
Q8CIE3
resolver
uniprot
Q8R311
resolver
uniprot_entry
A0A1W2P711_MOUSE
resolver
uniprot_entry
E9PY90_MOUSE
resolver
uniprot_entry
E9Q3S2_MOUSE
resolver
uniprot_entry
H3BJI6_MOUSE
resolver
uniprot_entry
H3BJS0_MOUSE
resolver
uniprot_entry
H3BK44_MOUSE
resolver
uniprot_entry
H3BK48_MOUSE
resolver
uniprot_entry
H3BKH2_MOUSE
resolver
uniprot_entry
MIA2_MOUSE
resolver
uniprot_sec
Q8CIE3
resolver
uniprot_sec
Q8R311
resolver
amino_acid_sequence
MAEVSVQRILLLVVSLAKCLEGTKLLAHLKKCGDLECETLISRVLALRDYTGPDCRYLNFTTGEEISVYVKLGGDREDLWAGSKGKDFGFFPRDAVEIEEVFISEEVEMPTKSDFLCLLGEGYIFGSEQSELNSEDDEEHMYPYEKDEDQNYNIYEGDFQPEPDLYAAAEGTLLEDQIPASEAPDDFRFSSEWKAWEGAGSQGGGEQDYTADSDQDLPSLSKPERQGWFGLGTEEAEEKVFESDTEPTQELALEEESDLEKLHSGEPQVELEQEPKSETLEFSSVPDEEYELESETESILKPQASGWFGEGLTSYLGFGNEEAGLELLSKESNPPLQDIPSSVPPDEEVPAPCREISTDKEDAVINDSSVLSPSWFYYGFGMLGFTNADEDNIVSDKGENEDGEVDNLKHPIGSDFDPEKEQERKIVTVETEDQAGTESVLEKTDESGSMQYLKKFFDNPWGFQSLPEDTELPFSKKMLDQDDIVENDKIEELSTENSPTGSMKDPVMLASRYVLSDIDSEVELPMEEHEGVHFKPSSSKRNEDDSNSWADPEELSVAQTDGSAEGALLDTQLVSPKEHAADFQLLKYLLQIDVYGFMSSALSPIEILLESVVAALPEDMRADFNPSGFSLELAVCVLSVGLLAVVLFLWRGFRSIRSRFYVGREKKLALELSALIEEKCKLLDKVSIVQKEYEGLESSLKEASFEKESTEAQSLEFVEGSQISEATYENLEQSKSKLEDEILLLEEKLEEERAKHSEQDELMADISKRIQSLEDESKSLKSQVAEAKTTFRIFEINEERLKGAIKDALNENSQLQESQKQLLQETEMMKEQVNDLDKQKVALEESRAQAEQALSEKESQIETLVTSLLKMKDWAAVLGEADDGNLDLDMKSGLENTAALDNQPKGALKKLIYAAKLNASLKALEGERNQVYTQLSEVDQVKEDLTEHIKSLESKQASLQSEKTEFESESQKLQQKLKVITELYQENEMKLHRKLTVEENYRLEKEEKLSKVDEKISHATEELETCRQRAKDLEEELERTIHSYQGQVISHEKKAHDNWLAARTLERNLNDLRKENAHNRQKLTETEFKFELLEKDPYALDVPNTAFGREHSPYGPSPLGRPPSETRAFLSPPTLLEGPLRLSPLLPGGGGRGSRGPENLLDHQMNTERGESSYDRLSDAPRAPSDRSLSPPWEQDRRMTAHPPPGQPYSDPALQRQDRFYPNSGRLSGPAELRSYNMPSLDKVDGPVPSEMESSGNGTKDNLGNSNVPDSPIPAECEAAGRGFFPPPFPPVRDPLFPVDPRSQFMRRGPSFPPPPPGSIYAAPRDYFPPRDFPGPPLPPFPGRTVYAPRGFPPYLPPRAGFFPPPPHPESRSELPPDLIPPSKEPAADPPETQEA
uniprot
proteins
function
FUNCTION: Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. Plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (By similarity). Thereby, may play a role in cholesterol and triglyceride homeostasis (PubMed:21807889). Required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic reticulum exit sites (By similarity). {ECO:0000250|UniProtKB:Q96PC5, ECO:0000269|PubMed:21807889}.
uniprot
proteins
mass_dalton
156461
uniprot
proteins
mutagenesis
MUTAGEN 90; /note="F->S: Decreases expression of isoform 1."; /evidence="ECO:0000269|PubMed:21807889
uniprot
proteins
protein_family
MIA/OTOR family
uniprot
proteins
pubmed
12586826
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21807889
uniprot
proteins
sequence_length
1396
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21807889}; Single-pass membrane protein {ECO:0000305|PubMed:21807889}. Note=Localizes to endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). {ECO:0000269|PubMed:21807889}.
uniprot
proteins
transmembrane_region
TRANSMEM 629..649; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins