CCDC66
entrez
285331
canonical
uniprot
A2RUB6
canonical
ensembl
ENSG00000180376
resolver
ensp
ENSP00000326050
resolver
ensp
ENSP00000378167
resolver
ensp
ENSP00000558415
resolver
ensp
ENSP00000558417
resolver
ensp
ENSP00000558419
resolver
ensp
ENSP00000603025
resolver
ensp
ENSP00000603027
resolver
ensp
ENSP00000603029
resolver
ensp
ENSP00000631393
resolver
ensp
ENSP00000670106
resolver
genesymbol
CCDC66
resolver
hgnc
HGNC:27709
resolver
uniprot
B3KWL8
resolver
uniprot
Q4VC34
resolver
uniprot
Q8N949
resolver
uniprot_entry
CCD66_HUMAN
resolver
uniprot_sec
B3KWL8
resolver
uniprot_sec
Q4VC34
resolver
uniprot_sec
Q8N949
resolver
amino_acid_sequence
MNLGDGLKLETELLDGKTKLILSPYEHKSKISVKMGNKAKIAKCPLRTKTGHILKSTQDTCIGSEKLLQKKPVGSETSQAKGEKNGMTFSSTKDLCKQCIDKDCLHIQKEISPATPNMQKTRNTVNTSLVGKQKPHKKHITAENMKSSLVCLTQDQLQQILMTVNQGNRSLSLTENGKEAKSQYSLYLNSISNQPKDENIMGLFKKTEMVSSVPAENKSVLNEHQETSKQCEQKIAIENEWKPADIFSTLGERECDRSSLEAKKAQWRKELDEQVALKKKEKEVSEKWNDPWKKSESDKIIWEKHQILDQSRETVLLEHPFSAVKQELQRKWIEELNKQIEDDRQRKIEEKIIYSKGEEHDRWAMHFDSLKSYPGSQSQLFSQSTHKQPEYFCVSPDTQELADVSSVCTPTTGSQVEPSEEEHIAKPIKDVVMANSKKTNFLRSMTALLDPAQIEERDRRRQKQLEHQKAITAQVEEKRRKKQLEEEQRKKEEQEEELRLAQEREEMQKQYEEDILKQKQKEEIMTLKTNELFQTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIKNLGVDTIQMEYNASNISNSRHDSDEISGKMNTYMNSTTSKKDTGVQTDDLNIGIFTNAESHCGSLMERDITNCSSPEISAELIGQFSTKKNKQELTQDKGASLEKENNRCNDQCNQFTRIEKQTKHMKKYPKRPDWNINKPPKRYIPASEKYPKQLQKQREEKKVRRQMELLHLVEKNNPGHLSQNRGISPEIFHSSHQETESKLRWHLVKKEEEPLNIHSFSKERSPSSPVPVVKNRTQQTQNTLHLPLKNSSYERENLISGSNQTELSSGISESSHFIPYVRTNEIYYLDPDAPLSGPSTQDPQYQNSQDCGQKRQLFDSDCVRDPLLNPNMVKNRDRQQAILKGLSELRQGLLQKQKELESSLLPLAENQEESFGSSF
uniprot
proteins
function
FUNCTION: Microtubule-binding protein required for ciliogenesis (PubMed:28235840). May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centriolar satellites (PubMed:28235840). Required for the assembly of signaling-competent cilia with proper structure and length (PubMed:36606424). Mediates this function in part by regulating transition zone assembly and basal body recruitment of the IFT-B complex (PubMed:36606424). Cooperates with the ciliopathy proteins CSPP1 and CEP104 during cilium length regulation (PubMed:36606424). Essential for cilium elongation, maintaining ciliary length and stability, and inhibiting disassembly (likely by stabilizing the axoneme) (By similarity). Also plays a role in ciliary Hedgehog pathway activation (By similarity). Plays two important roles during cell division (PubMed:35849559). First, is required for mitotic progression via regulation of spindle assembly, organization and orientation, levels of spindle microtubules (MTs), kinetochore-fiber integrity, and chromosome alignment (PubMed:35849559). Second, functions during cytokinesis in part by regulating assembly and organization of central spindle and midbody MTs (PubMed:35849559). Plays a role in retina morphogenesis and/or homeostasis (By similarity). {ECO:0000250|UniProtKB:Q6NS45, ECO:0000269|PubMed:28235840, ECO:0000269|PubMed:35849559}.
uniprot
proteins
mass_dalton
109411
uniprot
proteins
mutagenesis
MUTAGEN 208..948; /note="Missing: Loss of association with microtubules and localization to centrosomes."; /evidence="ECO:0000269|PubMed:28235840
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19777273
uniprot
proteins
pubmed
21680557
uniprot
proteins
pubmed
28235840
uniprot
proteins
pubmed
32453716
uniprot
proteins
pubmed
35849559
uniprot
proteins
pubmed
36606424
uniprot
proteins
sequence_length
948
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:28235840, ECO:0000269|PubMed:35849559, ECO:0000269|PubMed:36606424}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:28235840, ECO:0000269|PubMed:35849559, ECO:0000269|PubMed:36606424}. Cell projection, cilium {ECO:0000269|PubMed:28235840, ECO:0000269|PubMed:36606424}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:28235840, ECO:0000269|PubMed:36606424}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36606424}. Photoreceptor inner segment {ECO:0000269|PubMed:19777273}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:19777273}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:35849559}. Midbody {ECO:0000269|PubMed:35849559}. Note=Restricted to the centrosomes and the spindle microtubules during mitosis (PubMed:28235840). Enriched in the inner segment of the photoreceptor (PubMed:19777273). {ECO:0000269|PubMed:19777273, ECO:0000269|PubMed:28235840}.
uniprot
proteins