Aicda
entrez
11628
canonical
uniprot
Q9WVE0
canonical
ensembl
ENSMUSG00000040627
resolver
ensp
ENSMUSP00000040524
resolver
enst
ENSMUST00000043301
resolver
genesymbol
Aicda
resolver
genesymbol_syn
Aid
resolver
uniprot_entry
AICDA_MOUSE
resolver
amino_acid_sequence
MDSLLMKQKKFLYHFKNVRWAKGRHETYLCYVVKRRDSATSCSLDFGHLRNKSGCHVELLFLRYISDWDLDPGRCYRVTWFTSWSPCYDCARHVAEFLRWNPNLSLRIFTARLYFCEDRKAEPEGLRRLHRAGVQIGIMTFKDYFYCWNTFVENRERTFKAWEGLHENSVRLTRQLRRILLPLYEVDDLRDAFRMLGF
uniprot
proteins
ec_number
3.5.4.38
uniprot
proteins
function
FUNCTION: Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. {ECO:0000269|PubMed:12692563, ECO:0000269|PubMed:23803409}.
uniprot
proteins
mass_dalton
24031
uniprot
proteins
mutagenesis
MUTAGEN 15; /note="F->L: Severely decreased cytidine deaminase activity. Loss of mutagenic activity."; /evidence="ECO:0000269|PubMed:23803409"; MUTAGEN 56; /note="H->R: Loss of the cytidine deaminase activity; when associated with Q-58."; /evidence="ECO:0000269|PubMed:12692563"; MUTAGEN 58; /note="E->Q: Loss of the cytidine deaminase activity; when associated with R-56."; /evidence="ECO:0000269|PubMed:12692563"; MUTAGEN 143; /note="D->A: 10-fold decrease in MCM3AP-binding affinity, loss of relocalization to the nucleus in the presence of MCM3AP, decreased deamination activity to about 33% of the wild-type protein."; /evidence="ECO:0000269|PubMed:20507984
uniprot
proteins
post_translational_modification
PTM: Ser-38 is the major site whereas Thr-27 is the minor site of phosphorylation. Phosphorylation regulates its class-switch recombination activity (By similarity). {ECO:0000250}.; PTM: Probably monoubiquitinated on several residues by RNF126. {ECO:0000250|UniProtKB:Q9GZX7}.
uniprot
proteins
protein_family
Cytidine and deoxycytidylate deaminase family
uniprot
proteins
pubmed
10373455
uniprot
proteins
pubmed
12692563
uniprot
proteins
pubmed
20507984
uniprot
proteins
pubmed
21518874
uniprot
proteins
pubmed
23803409
uniprot
proteins
sequence_length
198
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20507984}. Cytoplasm {ECO:0000269|PubMed:20507984, ECO:0000269|PubMed:23803409}. Note=Predominantly cytoplasmic. In the presence of MCM3AP/GANP, relocalizes to the nucleus. {ECO:0000269|PubMed:20507984}.
uniprot
proteins