Gfi1
entrez
24388
canonical
uniprot
Q07120
canonical
ensembl
ENSRNOG00000002042
resolver
ensembl
ENSRNOG00055024076
resolver
ensembl
ENSRNOG00060011588
resolver
ensembl
ENSRNOG00065012750
resolver
ensp
ENSRNOP00000002807
resolver
ensp
ENSRNOP00055033663
resolver
ensp
ENSRNOP00060015446
resolver
ensp
ENSRNOP00065016011
resolver
enst
ENSRNOT00000002807
resolver
enst
ENSRNOT00055041363
resolver
enst
ENSRNOT00060019630
resolver
enst
ENSRNOT00065020805
resolver
genesymbol
Gfi1
resolver
genesymbol_syn
Gfi-1
resolver
uniprot_entry
GFI1_RAT
resolver
amino_acid_sequence
MPRSFLVKSKKAHSYHQPRSPGPDYSLRLETVPVPGRADGGAVSAGESKMEPRERLSPESQLTEAPDRASASPNSCEGSVCDPSSEFEDYWRPPSPSVSPASEKSLCRSLDEAQPYTLPFKPYAWSGLAGSDLRHLVQSYRQCSALERSAGLSLFCERGAESGRPAARYGSEQAAGGAGAGQPGSCGAASGATSAGGLGLYGDFAPAAAGLFERPSTAAGRLYQDRGHELHADKSVGVKVESELLCTRLLLGGGSYKCIKCSKVFSTPHGLEVHVRRSHSGTRPFACEMCGKTFGHAVSLEQHKAVHSQERSFDCKICGKSFKRSSTLSTHLLIHSDTRPYPCQYCGKRFHQKSDMKKHTFIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFGCDLCGKGFQRKVDLRRHRETQHGLK
uniprot
proteins
function
FUNCTION: Transcription repressor essential for hematopoiesis (By similarity). Functions in a cell-context and development-specific manner (By similarity). Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes (By similarity). Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development (By similarity). Inhibits SPI1 transcriptional activity at macrophage-specific genes, repressing macrophage differentiation of myeloid progenitor cells and promoting granulocyte commitment (By similarity). Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling (By similarity). Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA (By similarity). Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth (By similarity). Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters (PubMed:20190815). Required for the maintenance of inner ear hair cells (By similarity). In addition to its role in transcription, acts as a substrate adapter for PRMT1 in the DNA damage response: facilitates the recognition of TP53BP1 and MRE11 substrates by PRMT1, promoting their methylation and the DNA damage response (By similarity). {ECO:0000250|UniProtKB:P70338, ECO:0000250|UniProtKB:Q99684, ECO:0000269|PubMed:20190815}.
uniprot
proteins
mass_dalton
45858
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. {ECO:0000250}.
uniprot
proteins
pubmed
20153336
uniprot
proteins
pubmed
20190815
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8441411
uniprot
proteins
sequence_length
423
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Colocalizes with PIAS3 and RUNX1T1 in nuclear dots. {ECO:0000250}.
uniprot
proteins