SPIN1
entrez
10927
canonical
uniprot
Q9Y657
canonical
ensembl
ENSG00000106723
resolver
ensp
ENSP00000365019
resolver
ensp
ENSP00000523519
resolver
ensp
ENSP00000523520
resolver
ensp
ENSP00000523521
resolver
ensp
ENSP00000523522
resolver
ensp
ENSP00000523523
resolver
ensp
ENSP00000523524
resolver
ensp
ENSP00000523525
resolver
ensp
ENSP00000523526
resolver
ensp
ENSP00000523527
resolver
ensp
ENSP00000523528
resolver
ensp
ENSP00000523529
resolver
ensp
ENSP00000523530
resolver
ensp
ENSP00000523531
resolver
ensp
ENSP00000523532
resolver
ensp
ENSP00000523533
resolver
ensp
ENSP00000523534
resolver
ensp
ENSP00000523535
resolver
ensp
ENSP00000523536
resolver
ensp
ENSP00000523537
resolver
ensp
ENSP00000523538
resolver
ensp
ENSP00000523539
resolver
ensp
ENSP00000523540
resolver
ensp
ENSP00000523541
resolver
ensp
ENSP00000523543
resolver
ensp
ENSP00000523544
resolver
ensp
ENSP00000523545
resolver
ensp
ENSP00000523548
resolver
ensp
ENSP00000523549
resolver
ensp
ENSP00000523550
resolver
ensp
ENSP00000523551
resolver
ensp
ENSP00000523552
resolver
ensp
ENSP00000523553
resolver
ensp
ENSP00000523554
resolver
ensp
ENSP00000523555
resolver
ensp
ENSP00000523556
resolver
ensp
ENSP00000523557
resolver
ensp
ENSP00000523558
resolver
ensp
ENSP00000523559
resolver
ensp
ENSP00000523560
resolver
ensp
ENSP00000523561
resolver
ensp
ENSP00000523562
resolver
ensp
ENSP00000598901
resolver
ensp
ENSP00000598902
resolver
ensp
ENSP00000598903
resolver
ensp
ENSP00000598904
resolver
ensp
ENSP00000598905
resolver
ensp
ENSP00000598906
resolver
ensp
ENSP00000598907
resolver
ensp
ENSP00000598908
resolver
ensp
ENSP00000598909
resolver
ensp
ENSP00000598910
resolver
ensp
ENSP00000598911
resolver
ensp
ENSP00000598912
resolver
ensp
ENSP00000630882
resolver
ensp
ENSP00000630883
resolver
ensp
ENSP00000630884
resolver
ensp
ENSP00000630885
resolver
ensp
ENSP00000630886
resolver
ensp
ENSP00000630887
resolver
ensp
ENSP00000630888
resolver
ensp
ENSP00000630890
resolver
ensp
ENSP00000630891
resolver
ensp
ENSP00000630892
resolver
ensp
ENSP00000630893
resolver
ensp
ENSP00000630894
resolver
ensp
ENSP00000630895
resolver
ensp
ENSP00000630896
resolver
enst
ENST00000375859
resolver
enst
ENST00000853460
resolver
enst
ENST00000853461
resolver
enst
ENST00000853462
resolver
enst
ENST00000853463
resolver
enst
ENST00000853464
resolver
enst
ENST00000853465
resolver
enst
ENST00000853466
resolver
enst
ENST00000853467
resolver
enst
ENST00000853468
resolver
enst
ENST00000853469
resolver
enst
ENST00000853470
resolver
enst
ENST00000853471
resolver
enst
ENST00000853472
resolver
enst
ENST00000853473
resolver
enst
ENST00000853474
resolver
enst
ENST00000853475
resolver
enst
ENST00000853476
resolver
enst
ENST00000853477
resolver
enst
ENST00000853478
resolver
enst
ENST00000853479
resolver
enst
ENST00000853480
resolver
enst
ENST00000853481
resolver
enst
ENST00000853482
resolver
enst
ENST00000853484
resolver
enst
ENST00000853485
resolver
enst
ENST00000853486
resolver
enst
ENST00000853489
resolver
enst
ENST00000853490
resolver
enst
ENST00000853491
resolver
enst
ENST00000853492
resolver
enst
ENST00000853493
resolver
enst
ENST00000853494
resolver
enst
ENST00000853495
resolver
enst
ENST00000853496
resolver
enst
ENST00000853497
resolver
enst
ENST00000853498
resolver
enst
ENST00000853499
resolver
enst
ENST00000853500
resolver
enst
ENST00000853501
resolver
enst
ENST00000853502
resolver
enst
ENST00000853503
resolver
enst
ENST00000928842
resolver
enst
ENST00000928843
resolver
enst
ENST00000928844
resolver
enst
ENST00000928845
resolver
enst
ENST00000928846
resolver
enst
ENST00000928847
resolver
enst
ENST00000928848
resolver
enst
ENST00000928849
resolver
enst
ENST00000928850
resolver
enst
ENST00000928851
resolver
enst
ENST00000928852
resolver
enst
ENST00000928853
resolver
enst
ENST00000960823
resolver
enst
ENST00000960824
resolver
enst
ENST00000960825
resolver
enst
ENST00000960826
resolver
enst
ENST00000960827
resolver
enst
ENST00000960828
resolver
enst
ENST00000960829
resolver
enst
ENST00000960831
resolver
enst
ENST00000960832
resolver
enst
ENST00000960833
resolver
enst
ENST00000960834
resolver
enst
ENST00000960835
resolver
enst
ENST00000960836
resolver
enst
ENST00000960837
resolver
genesymbol
SPIN1
resolver
genesymbol_syn
OCR
resolver
genesymbol_syn
SPIN
resolver
hgnc
HGNC:11243
resolver
uniprot
A8K0X6
resolver
uniprot
B3KRQ4
resolver
uniprot
Q7KZJ8
resolver
uniprot
Q9GZT2
resolver
uniprot
Q9H0N7
resolver
uniprot_entry
SPIN1_HUMAN
resolver
uniprot_sec
A8K0X6
resolver
uniprot_sec
B3KRQ4
resolver
uniprot_sec
Q7KZJ8
resolver
uniprot_sec
Q9GZT2
resolver
uniprot_sec
Q9H0N7
resolver
amino_acid_sequence
MKTPFGKTPGQRSRADAGHAGVSANMMKKRTSHKKHRSSVGPSKPVSQPRRNIVGCRIQHGWKEGNGPVTQWKGTVLDQVPVNPSLYLIKYDGFDCVYGLELNKDERVSALEVLPDRVATSRISDAHLADTMIGKAVEHMFETEDGSKDEWRGMVLARAPVMNTWFYITYEKDPVLYMYQLLDDYKEGDLRIMPDSNDSPPAEREPGEVVDSLVGKQVEYAKEDGSKRTGMVIHQVEAKPSVYFIKFDDDFHIYVYDLVKTS
uniprot
proteins
function
FUNCTION: Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and 'Lys-9' (H3K4me3K9me3) and is involved in piRNA-mediated retrotransposon silencing during spermatogenesis (PubMed:33574238). Plays a key role in the initiation of the PIWIL4-piRNA pathway, a pathway that directs transposon DNA methylation and silencing in the male embryonic germ cells, by promoting recruitment of DNA methylation machinery to transposons: binds young, but not old, LINE1 transposons, which are specifically marked with H3K4me3K9me3, and promotes the recruitment of PIWIL4 and SPOCD1 to transposons, leading to piRNA-directed DNA methylation (By similarity). Also recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway downstream of PRMT2 (PubMed:22258766, PubMed:29061846). In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo (By similarity). Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption (By similarity). {ECO:0000250|UniProtKB:Q61142, ECO:0000269|PubMed:21960006, ECO:0000269|PubMed:22258766, ECO:0000269|PubMed:24589551, ECO:0000269|PubMed:29061846, ECO:0000269|PubMed:33574238}.
uniprot
proteins
mass_dalton
29601
uniprot
proteins
mutagenesis
MUTAGEN 62; /note="W->A: Decreased binding to histone H3 trimethylated at both 'Lys-4' and 'Lys-9' (H3K4me3K9me3)."; /evidence="ECO:0000269|PubMed:33574238"; MUTAGEN 72; /note="W->A,R: Impaired binding to histone H3K4me3 and H3R8me2a and impaired ability to activate the Wnt signaling pathway. ecreased binding to histone H3 trimethylated at both 'Lys-4' and 'Lys-9' (H3K4me3K9me3)."; /evidence="ECO:0000269|PubMed:24589551, ECO:0000269|PubMed:33574238"; MUTAGEN 91; /note="Y->A: Decreased binding to histone H3 trimethylated at both 'Lys-4' and 'Lys-9' (H3K4me3K9me3)."; /evidence="ECO:0000269|PubMed:33574238"; MUTAGEN 98; /note="Y->A: Decreased binding to histone H3 trimethylated at both 'Lys-4' and 'Lys-9' (H3K4me3K9me3)."; /evidence="ECO:0000269|PubMed:33574238"; MUTAGEN 98; /note="Y->R: Impaired binding to histone H3K4me3 and H3R8me2a and impaired ability to activate the Wnt signaling pathway."; /evidence="ECO:0000269|PubMed:24589551"; MUTAGEN 109; /note="S->A: Impaired phosphorylation."; /evidence="ECO:0000269|PubMed:22258766"; MUTAGEN 124; /note="S->A: Impaired phosphorylation."; /evidence="ECO:0000269|PubMed:22258766"; MUTAGEN 141; /note="F->A: Impaired binding to histone H3K4me3 and H3R8me2a and impaired ability to activate the Wnt signaling pathway. Impaired ability to activate expression of pre-rRNA. Nearly abolished binding to histone H3 trimethylated at both 'Lys-4' and 'Lys-9' (H3K4me3K9me3)."; /evidence="ECO:0000269|PubMed:21960006, ECO:0000269|PubMed:24589551, ECO:0000269|PubMed:33574238"; MUTAGEN 142; /note="E->A: Impaired binding to histone H3K4me3 and H3R8me2a."; /evidence="ECO:0000269|PubMed:24589551"; MUTAGEN 170; /note="Y->A: Impaired binding to histone H3K4me3 and H3R8me2a and impaired ability to activate the Wnt signaling pathway. Impaired ability to activate expression of pre-rRNA."; /evidence="ECO:0000269|PubMed:21960006, ECO:0000269|PubMed:24589551"; MUTAGEN 177; /note="Y->A: Impaired binding to histone H3K4me3 and H3R8me2a."; /evidence="ECO:0000269|PubMed:24589551"; MUTAGEN 184; /note="D->A,R: Impaired binding to histone H3K4me3 and H3R8me2a."; /evidence="ECO:0000269|PubMed:23077255, ECO:0000269|PubMed:24589551"; MUTAGEN 189; /note="D->A,R: Impaired binding to histone H3K4me3."; /evidence="ECO:0000269|PubMed:23077255"; MUTAGEN 251; /note="F->R: Impaired binding to histone H3K4me3 and H3R8me2a and impaired ability to activate the Wnt signaling pathway."; /evidence="ECO:0000269|PubMed:24589551
uniprot
proteins
post_translational_modification
PTM: Phosphorylated during oocyte meiotic maturation. {ECO:0000250|UniProtKB:Q61142}.
uniprot
proteins
protein_family
SPIN/STSY family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16098913
uniprot
proteins
pubmed
17082182
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21960006
uniprot
proteins
pubmed
22258766
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23077255
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24589551
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
29061846
uniprot
proteins
pubmed
33574238
uniprot
proteins
sequence_length
262
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16098913, ECO:0000269|PubMed:29061846}. Nucleus, nucleolus {ECO:0000269|PubMed:21960006}.
uniprot
proteins