Ada
entrez
24165
canonical
uniprot
Q920P6
canonical
ensembl
ENSRNOG00000010265
resolver
ensembl
ENSRNOG00055003913
resolver
ensembl
ENSRNOG00060001531
resolver
ensembl
ENSRNOG00065025525
resolver
ensp
ENSRNOP00000014151
resolver
ensp
ENSRNOP00000090362
resolver
ensp
ENSRNOP00055004764
resolver
ensp
ENSRNOP00060001496
resolver
ensp
ENSRNOP00065036097
resolver
enst
ENSRNOT00000014151
resolver
enst
ENSRNOT00000114756
resolver
enst
ENSRNOT00055006244
resolver
enst
ENSRNOT00060002310
resolver
enst
ENSRNOT00065044013
resolver
genesymbol
Ada
resolver
uniprot
A0A8I6GI51
resolver
uniprot_entry
A0A8I6GI51_RAT
resolver
uniprot_entry
ADA_RAT
resolver
amino_acid_sequence
MAQTPAFNKPKVELHVHLDGAIKPETILYYGKKRGIDLPADTVEGLRNIIGMDKPLSLPDFLAKFDYYMPAIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYSPHLLANSKVDPIPWNQAEGDLTPDEVVDLVNQGLQEGEQAFGIKVRSILCCMRHQPSWSPEVLELCKKYHQKTVVAMDLAGDETIEGSSLFPGHVEAYEGAVKDGIHRTVHAGEVGSAEVVREAVDILKTERVGHGYHTIEDEALYNRLLKENMHFEVCPWSSYLTGAWNPKTTHAVVRFKDDQANYSLNSDDPLIFKSTVDTDYQMVKKDMGFTEEEFKRLNINAAKSSFLPEDEKKELLERLYKEYQ
uniprot
proteins
ec_number
3.5.4.4
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine (PubMed:19900420). Plays an important role in purine metabolism and in adenosine homeostasis (By similarity). Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events (By similarity). Acts as a positive regulator of T-cell coactivation, by binding DPP4 (By similarity). Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion (By similarity). Enhances dendritic cell immunogenicity by affecting dendritic cell costimulatory molecule expression and cytokines and chemokines secretion (By similarity). Enhances CD4+ T-cell differentiation and proliferation (By similarity). Acts as a positive modulator of adenosine receptors ADORA1 and ADORA2A, by enhancing their ligand affinity via conformational change (By similarity). Stimulates plasminogen activation (By similarity). Plays a role in male fertility (By similarity). Plays a protective role in early postimplantation embryonic development (By similarity) (PubMed:19900420). Also responsible for the deamination of cordycepin (3'-deoxyadenosine), a fungal natural product that shows antitumor, antibacterial, antifungal, antivirus, and immune regulation properties (By similarity). {ECO:0000250|UniProtKB:P00813, ECO:0000250|UniProtKB:P03958, ECO:0000250|UniProtKB:P56658, ECO:0000269|PubMed:19900420}.
uniprot
proteins
mass_dalton
39899
uniprot
proteins
protein_family
Adenosine and AMP deaminases family
uniprot
proteins
protein_family
Metallo-dependent hydrolases superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19900420
uniprot
proteins
pubmed
8783262
uniprot
proteins
sequence_length
352
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P00813}; Peripheral membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}. Cell junction {ECO:0000250|UniProtKB:P00813}. Cytoplasmic vesicle lumen {ECO:0000269|PubMed:19900420, ECO:0000269|PubMed:8783262}. Cytoplasm {ECO:0000250}. Lysosome {ECO:0000250|UniProtKB:P00813}. Note=Colocalized with DPP4 at the cell surface. {ECO:0000250|UniProtKB:P00813}.
uniprot
proteins