CPTP
entrez
80772
canonical
uniprot
Q5TA50
canonical
ensembl
ENSG00000224051
resolver
ensp
ENSP00000343890
resolver
ensp
ENSP00000570337
resolver
ensp
ENSP00000570338
resolver
ensp
ENSP00000570339
resolver
ensp
ENSP00000570340
resolver
ensp
ENSP00000570341
resolver
ensp
ENSP00000570342
resolver
ensp
ENSP00000626352
resolver
enst
ENST00000343938
resolver
enst
ENST00000900278
resolver
enst
ENST00000900279
resolver
enst
ENST00000900280
resolver
enst
ENST00000900281
resolver
enst
ENST00000900282
resolver
enst
ENST00000900283
resolver
enst
ENST00000956293
resolver
genesymbol
CPTP
resolver
genesymbol
GLTPD1
resolver
genesymbol_syn
GLTPD1
resolver
hgnc
HGNC:28116
resolver
uniprot
Q4G0E6
resolver
uniprot
Q7L5A4
resolver
uniprot
S4S694
resolver
uniprot_entry
CPTP_HUMAN
resolver
uniprot_entry
S4S694_HUMAN
resolver
uniprot_sec
Q4G0E6
resolver
uniprot_sec
Q7L5A4
resolver
amino_acid_sequence
MDDSETGFNLKVVLVSFKQCLDEKEEVLLDPYIASWKGLVRFLNSLGTIFSFISKDVVSKLRIMERLRGGPQSEHYRSLQAMVAHELSNRLVDLERRSHHPESGCRTVLRLHRALHWLQLFLEGLRTSPEDARTSALCADSYNASLAAYHPWVVRRAVTVAFCTLPTREVFLEAMNVGPPEQAVQMLGEALPFIQRVYNVSQKLYAEHSLLDLP
uniprot
proteins
function
FUNCTION: Mediates the intracellular transfer of ceramide-1-phosphate (C1P) between organelle membranes and the cell membrane. Required for normal structure of the Golgi stacks. Can bind phosphoceramides with a variety of aliphatic chains, but has a preference for lipids with saturated C16:0 or monounsaturated C18:1 aliphatic chains, and is inefficient with phosphoceramides containing lignoceryl (C24:0). Plays a role in the regulation of the cellular levels of ceramide-1-phosphate, and thereby contributes to the regulation of phospholipase PLA2G4A activity and the release of arachidonic acid. Has no activity with galactosylceramide, lactosylceramide, sphingomyelin, phosphatidylcholine, phosphatidic acid and ceramide. C1P transfer is stimulated by phosphatidylserine in C1P source vesicles (PubMed:28011644). Regulates autophagy, inflammasome mediated IL1B and IL18 processing, and pyroptosis, but not apoptosis (PubMed:29164996). {ECO:0000269|PubMed:23863933, ECO:0000269|PubMed:28011644, ECO:0000269|PubMed:29164996}.
uniprot
proteins
mass_dalton
24365
uniprot
proteins
mutagenesis
MUTAGEN 42; /note="F->A: Increases phosphoceramide transfer."; /evidence="ECO:0000269|PubMed:23863933"; MUTAGEN 43; /note="L->R: Nearly abolishes phosphoceramide transfer."; /evidence="ECO:0000269|PubMed:23863933"; MUTAGEN 50; /note="F->R: Slightly reduces phosphoceramide transfer."; /evidence="ECO:0000269|PubMed:23863933"; MUTAGEN 53; /note="I->N: Slightly decreases phosphoceramide transfer."; /evidence="ECO:0000269|PubMed:23863933"; MUTAGEN 56; /note="D->V: Slightly decreases phosphoceramide transfer."; /evidence="ECO:0000269|PubMed:23863933"; MUTAGEN 60; /note="K->A: Nearly abolishes phosphoceramide transfer. Induces autophagy in a dominant negative manner."; /evidence="ECO:0000269|PubMed:23863933, ECO:0000269|PubMed:29164996"; MUTAGEN 97; /note="R->L: No effect."; /evidence="ECO:0000269|PubMed:23863933"; MUTAGEN 106; /note="R->L: Nearly abolishes phosphoceramide transfer. Induces autophagy in a dominant negative manner."; /evidence="ECO:0000269|PubMed:23863933, ECO:0000269|PubMed:29164996"; MUTAGEN 110; /note="R->L: Reduces phosphoceramide transfer."; /evidence="ECO:0000269|PubMed:23863933"; MUTAGEN 113; /note="R->E,L: Strongly reduces phosphoceramide transfer."; /evidence="ECO:0000269|PubMed:23863933"; MUTAGEN 117; /note="W->A: Slightly reduces phosphoceramide transfer."; /evidence="ECO:0000269|PubMed:23863933"; MUTAGEN 118; /note="L->R: Abolishes phosphoceramide transfer."; /evidence="ECO:0000269|PubMed:23863933"; MUTAGEN 149; /note="Y->A: Reduces phosphoceramide transfer."; /evidence="ECO:0000269|PubMed:23863933"; MUTAGEN 158; /note="V->N: Abolishes phosphoceramide transfer."; /evidence="ECO:0000269|PubMed:23863933
uniprot
proteins
protein_family
GLTP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
23863933
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28011644
uniprot
proteins
pubmed
29164996
uniprot
proteins
sequence_length
214
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:23863933}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:23863933}; Peripheral membrane protein {ECO:0000269|PubMed:23863933}. Cell membrane {ECO:0000269|PubMed:23863933}; Peripheral membrane protein {ECO:0000269|PubMed:23863933}; Cytoplasmic side {ECO:0000269|PubMed:23863933}. Endosome membrane {ECO:0000269|PubMed:23863933}; Peripheral membrane protein {ECO:0000269|PubMed:23863933}. Nucleus outer membrane {ECO:0000269|PubMed:23863933}; Peripheral membrane protein {ECO:0000269|PubMed:23863933}.
uniprot
proteins