Nos1ap
entrez
192363
canonical
uniprot
O54960
canonical
genesymbol
Nos1ap
resolver
genesymbol_syn
Capon
resolver
uniprot_entry
CAPON_RAT
resolver
amino_acid_sequence
MPSKTKYNLVDDGHDLRIPLHNEDAFQHGISFEAKYVGSLDVPRPNSRVEIVAAMRRIRYEFKAKNIKKKKVSIMVSVDGVKVILKKKKKKKEWTWDESKMLVMQDPIYRIFYVSHDSQDLKIFSYIARDGASNIFRCNVFKSKKKSQAMRIVRTVGQAFEVCHKLSLQHTQQNADGQEDGESERNSDGSGDPGRQLTGAERVSTATAEETDIDAVEVPLPGNDILEFSRGVTDLDAIGKDGGSHIDTTVSPHPQEPMLAASPRMLLPSSSSSKPPGLGTGTPLSTHHQMQLLQQLLQQQQQQTQVAVAQVHLLKDQLAAEAAARLEAQARVHQLLLQNKDMLQHISLLVKQVQELELKLSGQSTMGSQDSLLEITFRSGALPVLCESTTPKPEDLHSPLLGAGLADFAHPVGSPLGRRDCLVKLECFRFLPAEDNQPMAQGEPLLGGLELIKFRESGIASEYESNTDESEERDSWSQEELPRLLNVLQRQELGDSLDDEIAV
uniprot
proteins
function
FUNCTION: Adapter protein involved in neuronal nitric-oxide (NO) synthesis regulation via its association with nNOS/NOS1. The complex formed with NOS1 and synapsins is necessary for specific NO and synapsin functions at a presynaptic level. Mediates an indirect interaction between NOS1 and RASD1 leading to enhance the ability of NOS1 to activate RASD1. Competes with DLG4 for interaction with NOS1, possibly affecting NOS1 activity by regulating the interaction between NOS1 and DLG4. In kidney podocytes, plays a role in podosomes and filopodia formation through CDC42 activation (PubMed:33523862). {ECO:0000269|PubMed:33523862, ECO:0000269|PubMed:9459447}.
uniprot
proteins
mass_dalton
55864
uniprot
proteins
mutagenesis
MUTAGEN 501; /note="I->S,A: Does not affect interaction with NOS1."; /evidence="ECO:0000269|PubMed:9459447"; MUTAGEN 502; /note="A->D: Abolishes interaction with NOS1."; /evidence="ECO:0000269|PubMed:9459447"; MUTAGEN 503; /note="V->A: Abolishes interaction with NOS1."; /evidence="ECO:0000269|PubMed:9459447
uniprot
proteins
pubmed
10623522
uniprot
proteins
pubmed
11086993
uniprot
proteins
pubmed
11867766
uniprot
proteins
pubmed
33523862
uniprot
proteins
pubmed
9459447
uniprot
proteins
sequence_length
503
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, filopodium {ECO:0000269|PubMed:33523862}. Cell projection, podosome {ECO:0000269|PubMed:33523862}.
uniprot
proteins