Hck
entrez
25734
canonical
uniprot
P50545
canonical
ensembl
ENSRNOG00000009331
resolver
ensembl
ENSRNOG00055024615
resolver
ensembl
ENSRNOG00060030764
resolver
ensembl
ENSRNOG00065024295
resolver
ensp
ENSRNOP00000012432
resolver
ensp
ENSRNOP00055034592
resolver
ensp
ENSRNOP00060044415
resolver
ensp
ENSRNOP00065034069
resolver
enst
ENSRNOT00055042361
resolver
enst
ENSRNOT00060053461
resolver
enst
ENSRNOT00065041684
resolver
genesymbol
Hck
resolver
uniprot
Q64647
resolver
uniprot
Q6AYV7
resolver
uniprot_entry
HCK_RAT
resolver
uniprot_sec
Q64647
resolver
uniprot_sec
Q6AYV7
resolver
activity_regulation
ACTIVITY REGULATION: Subject to autoinhibition, mediated by intramolecular interactions involving the SH2 and SH3 domains. Kinase activity is also regulated by phosphorylation at regulatory tyrosine residues. Phosphorylation at Tyr-409 is required for optimal activity. Phosphorylation at Tyr-520 inhibits kinase activity (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MGGRSSCEDPGCPRGEGRVPRMGCVKSRFLREGSKASKIEPNANQKGPVYVPDPTSPKKLGPNSINSLPPGVVEGSEDTIVVALYDYEAIHREDLSFQKGDQMVVLEESGEWWKARSLATKKEGYIPSNYVARVNSLETEEWFFKGISRKDAERHLLAPGNMLGSFMIRDSETTKGSYSLSVRDFDPQHGDTVKHYKIRTLDSGGFYISPRSTFSSLQELVVHYKKGKDGLCQKLSVPCVSPKPQKPWEKDAWEIPRESLQMEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVEAFLAEANLMKTLQHDKLVKLHAVVSQEPIFIVTEFMAKGSLLDFLKSEEGSKQPLPKLIDFSAQISEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARIIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPYPGMSNPEVIRALEHGYRMPRPDNCPEELYSIMIRCWKNRPEERPTFEYIQSVLDDFYTATESQYQQQP
uniprot
proteins
ec_number
2.7.10.2
uniprot
proteins
function
FUNCTION: Non-receptor tyrosine-protein kinase found in hematopoietic cells that transmits signals from cell surface receptors and plays an important role in the regulation of innate immune responses, including neutrophil, monocyte, macrophage and mast cell functions, phagocytosis, cell survival and proliferation, cell adhesion and migration. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as FCGR1A and FCGR2A, but also CSF3R, PLAUR, the receptors for IFNG, IL2, IL6 and IL8, and integrins, such as ITGB1 and ITGB2. During the phagocytic process, mediates mobilization of secretory lysosomes, degranulation, and activation of NADPH oxidase to bring about the respiratory burst. Plays a role in the release of inflammatory molecules. Promotes reorganization of the actin cytoskeleton and actin polymerization, formation of podosomes and cell protrusions. Inhibits TP73-mediated transcription activation and TP73-mediated apoptosis. Phosphorylates CBL in response to activation of immunoglobulin gamma Fc region receptors. Phosphorylates ADAM15, BCR, ELMO1, FCGR2A, GAB1, GAB2, RAPGEF1, STAT5B, TP73, VAV1 and WAS (By similarity). {ECO:0000250, ECO:0000269|PubMed:14551197}.
uniprot
proteins
mass_dalton
59154
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on several tyrosine residues. Autophosphorylated. Becomes rapidly phosphorylated upon activation of the immunoglobulin receptors FCGR1A and FCGR2A. Phosphorylation at Tyr-409 increases kinase activity. Phosphorylation at Tyr-520 inhibits kinase activity. Kinase activity is not required for phosphorylation at Tyr-520, suggesting that this site may be a target of other kinases (By similarity). {ECO:0000250}.; PTM: Ubiquitinated by CBL, leading to its degradation via the proteasome. {ECO:0000250}.; PTM: Isoform 2 palmitoylation at position 2 requires prior myristoylation. Palmitoylation at position 3 is required for caveolar localization of isoform 2. {ECO:0000250|UniProtKB:P08631}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
SRC subfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
14551197
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1764064
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
524
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 1]: Membrane; Lipid-anchor. Membrane, caveola {ECO:0000250}. Lysosome {ECO:0000250}. Cell projection, podosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Associated with specialized secretory lysosomes called azurophil granules. A fraction of this isoform is found in the cytoplasm, some of this fraction is myristoylated (By similarity). {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Lipid-anchor. Membrane, caveola {ECO:0000250}; Lipid-anchor {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Golgi apparatus {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Lysosome {ECO:0000250}. Nucleus {ECO:0000250}. Note=A small fraction of this isoform is associated with caveolae. Localization at the cell membrane and at caveolae requires palmitoylation at Cys-3. Colocalizes with the actin cytoskeleton at focal adhesions (By similarity). {ECO:0000250}.
uniprot
proteins