Hsd17b3
entrez
117182
canonical
uniprot
O54939
canonical
ensembl
ENSRNOG00000019096
resolver
ensp
ENSRNOP00000025850
resolver
genesymbol
Hsd17b3
resolver
genesymbol_syn
Edh17b3
resolver
uniprot_entry
DHB3_RAT
resolver
amino_acid_sequence
MEQFLLSVGLLVCLVCLVKCVRFSRYLFLSFCKALPGSFLRSMGQWAVITGAGDGIGKAYSFELARHGLNVVLISRTLEKLQVISEEIERTTGSRVKVVQADFTREDIYDHIEEQLKGLEIGVLVNNVGMLPNLLPSHFLSTSGESQSVIHCNITSVVKMTQLVLKHMESRRRGLILNISSGVGVRPWPLYSLYSASKAFVCTFSKALNVEYRDKGIIIQVLTPYSVSTPMTKYLNTSRVTKTADEFVKESLKYVTIGAETCGCLAHEILAIILNLIPSRIFYSSTTQRFLLKQFSDYLKSNISNR
uniprot
proteins
ec_number
1.1.1.62
uniprot
proteins
ec_number
1.1.1.64
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of 17-oxosteroids to 17beta-hydroxysteroids. Favors the reduction of androstenedione to testosterone. Testosterone is the key androgen driving male development and function (By similarity). Uses NADPH while the two other EDH17B enzymes use NADH. Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17. Can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms (By similarity). Plays a role in the rate-limiting-step for the maximum level of testosterone production by the testis but does not affect basal testosterone production (By similarity). {ECO:0000250|UniProtKB:P37058, ECO:0000250|UniProtKB:P70385}.
uniprot
proteins
mass_dalton
34223
uniprot
proteins
pathway_participation
PATHWAY: Hormone biosynthesis; testosterone biosynthesis. {ECO:0000250|UniProtKB:P37058}.; PATHWAY: Steroid metabolism. {ECO:0000250|UniProtKB:P37058}.
uniprot
proteins
protein_family
17-beta-HSD 3 subfamily
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
sequence_length
306
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:P37058}.
uniprot
proteins