Scube3
entrez
268935
canonical
uniprot
Q66PY1
canonical
ensembl
ENSMUSG00000038677
resolver
ensp
ENSMUSP00000038366
resolver
ensp
ENSMUSP00000156515
resolver
ensp
ENSMUSP00000314322
resolver
ensp
ENSMUSP00000330895
resolver
enst
ENSMUST00000137147
resolver
genesymbol
Scube3
resolver
uniprot
A0A3B2WCG9
resolver
uniprot
B2KF22
resolver
uniprot
Q68FG9
resolver
uniprot_entry
A0A3B2WCG9_MOUSE
resolver
uniprot_entry
SCUB3_MOUSE
resolver
uniprot_sec
B2KF22
resolver
uniprot_sec
Q68FG9
resolver
amino_acid_sequence
MGSGRVPGLCLLLLLVHARAAQHGKAAQDVDECVEGTDNCHIDAICQNTPRSYKCICKSGYTGDGKHCKDVDECEREDNAGCVHDCVNIPGNYRCTCYDGFHLAHDGHNCLDVDECAEGNGGCQQSCVNMMGSYECHCRDGFFLSDNQHTCIQRPEEGMNCMNKNHGCAHICRETPKGGIACECRPGFELTKNQRDCKLTCNYGNGGCQHTCDDTEQGPRCGCHVKFVLHTDGKTCIETCAVNNGGCDSKCHDAATGVHCSCPVGFMLQPDRKTCKDIDECRLNNGGCDHICRNTVGSFECSCKKGYKLLINERSCQDIDECSFDRTCDHMCVNTPGSFQCLCHRGYLLYGVTHCGDVDECSINKGGCRFGCINTPGSYQCTCPAGQGRLHWNGKDCTEPVKCQSSLGASKAMLSCNRSGKKDTCALTCPSRARFLPESENGFTVSCGTPSPKAAPARVIHSGNSTVSSSCHEAAVLPVKQRASFKIKDAKCRLHLRNKGKAEEASRILGPGSVPCSDCLVTFIHLKCDSSRKGKGRRARTPPGKEVTRLTLELEAEVRAEETTAGCGLPCLRQRMERRLKGSLKMLRKSINQDRFLLRLAGLDYELAHKPGLGAGDRAELVEVCRPGQHRAGTKCVSCPQGTYYHGQTEQCVPCPAGTFQEREGQLSCDLCPGSDAHGPLGATNVTTCAGQCPPGHHSGDGFKPCQPCPRGTYQPEAGRTLCFPCGGGLTTKHEGAVSFQDCDTKVQCSPGHYYNTSIHRCIRCAVGSYQPDFRQNFCTRCPGNTSTDFDGSTSVAQCKNRQCGGELGEFTGYIESPNYPGNYPAGVECVWNINPPPKRKILIVVPEIFLPSEDECGDVLVMRKNSSPSSITTYETCQTYERPIAFTARSRKLWINFKTSEANSARGFQIPYVTYDEDYEQLVEDIVRDGRLYASENHQEILKDKKLIKAFFEVLAHPQNYFKYTEKHKEMLPKSFIKLLRSKVSSFLRPYK
uniprot
proteins
function
FUNCTION: Is a positive regulator of the BMP signaling pathway, required for proper chondrogenesis, osteogenesis and skeletal development (PubMed:33308444). It acts as a coreceptor for BMP ligands, particularly BMP2 and BMP4, facilitating their interactions with BMP type I receptors (By similarity). It is required for ligand-induced recruitment of BMP receptors to lipid rafts (PubMed:33308444). Binds to TGFBR2 and activates TGFB signaling (By similarity). {ECO:0000250|UniProtKB:Q8IX30, ECO:0000269|PubMed:33308444}.
uniprot
proteins
mass_dalton
108984
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:15234972}.; PTM: Proteolytic cleavage produces a CUB-containing C-terminal fragment that retains the ability to bind to TGFBR2. This reaction is catalyzed in vitro by MMP2 and, to a lesser extent, by MMP9 (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
15234972
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
33308444
uniprot
proteins
sequence_length
993
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8IX30}. Cell surface {ECO:0000250|UniProtKB:Q8IX30}.
uniprot
proteins