Klhdc10
entrez
76788
canonical
uniprot
Q6PAR0
canonical
ensembl
ENSMUSG00000029775
resolver
ensp
ENSMUSP00000064594
resolver
ensp
ENSMUSP00000069669
resolver
genesymbol
Klhdc10
resolver
genesymbol_syn
Kiaa0265
resolver
uniprot
Q6A095
resolver
uniprot
Q8BH94
resolver
uniprot
Q8BPK7
resolver
uniprot
Q8C3Q4
resolver
uniprot
Q8C7G4
resolver
uniprot
Q9CWF4
resolver
uniprot_entry
KLD10_MOUSE
resolver
uniprot_sec
Q6A095
resolver
uniprot_sec
Q8BH94
resolver
uniprot_sec
Q8BPK7
resolver
uniprot_sec
Q8C3Q4
resolver
uniprot_sec
Q8C7G4
resolver
uniprot_sec
Q9CWF4
resolver
amino_acid_sequence
MSAAQGWDRNRRRGGGAAGGASGVSGAGAAGGGRGTGQLNRFVQLSGRPHLPGKKKIRWDPVRRRFIQSCPIIRIPNRFLRGHRPPPARSGHRCVADNTNLYVFGGYNPDYDESGGPDNEDYPLFRELWRYHFATGVWHQMGTDGYMPRELASMSLVLHGNNLLVFGGTGIPFGESNGNDVHVCNVKYKRWALLSCRGKRPSRIYGQAMALINGSLYVFGGTTGYIYSTDLHKLDLNTMVWTQLKPNNLSCDLPEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPATMPEPVYFHCAAVTPAGCMYIHGGVVNIHENKRTGSLFKIWLVVPSLLELAWEKLLAAFPNLANLSRTQLLHLGLTQELIERLK
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C-terminus of target proteins, leading to their ubiquitination and degradation (By similarity). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (By similarity). The CRL2(KLHDC10) complex specifically recognizes proteins with a proline-glycine (Pro-Gly) or an alanine tail (CAT tail) at the C-terminus, leading to their ubiquitination and degradation (By similarity). The CRL2(KLHDC10) complex is involved in the ribosome-associated quality control (RQC) pathway, which mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes: CRL2(KLHDC10) acts downstream of NEMF and recognizes CAT tails associated with stalled nascent chains, leading to their ubiquitination and degradation (By similarity). Participates in the oxidative stress-induced cell death through MAP3K5 activation (By similarity). Inhibits PPP5C phosphatase activity on MAP3K5 (PubMed:23102700). Acts as a regulator of necroptosis (PubMed:27631783). {ECO:0000250|UniProtKB:Q6PID8, ECO:0000269|PubMed:23102700, ECO:0000269|PubMed:27631783}.
uniprot
proteins
mass_dalton
49012
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q6PID8}.
uniprot
proteins
protein_family
KLHDC10 family
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23102700
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
27631783
uniprot
proteins
sequence_length
439
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6PID8}. Cytoplasm {ECO:0000250|UniProtKB:Q6PID8}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:23102700}.
uniprot
proteins