CD48
entrez
962
canonical
uniprot
P09326
canonical
ensembl
ENSG00000117091
resolver
ensp
ENSP00000357025
resolver
ensp
ENSP00000484431
resolver
ensp
ENSP00000572651
resolver
ensp
ENSP00000572652
resolver
enst
ENST00000613788
resolver
genesymbol
CD48
resolver
genesymbol_syn
BCM1
resolver
genesymbol_syn
BLAST1
resolver
hgnc
HGNC:1683
resolver
uniprot
A0A087X1S7
resolver
uniprot
Q5U055
resolver
uniprot
Q8MGR0
resolver
uniprot_entry
A0A087X1S7_HUMAN
resolver
uniprot_entry
CD48_HUMAN
resolver
uniprot_sec
Q5U055
resolver
uniprot_sec
Q8MGR0
resolver
amino_acid_sequence
MCSRGWDSCLALELLLLPLSLLVTSIQGHLVHMTVVSGSNVTLNISESLPENYKQLTWFYTFDQKIVEWDSRKSKYFESKFKGRVRLDPQSGALYISKVQKEDNSTYIMRVLKKTGNEQEWKIKLQVLDPVPKPVIKIEKIEDMDDNCYLKLSCVIPGESVNYTWYGDKRPFPKELQNSVLETTLMPHNYSRCYTCQVSNSVSSKNGTVCLSPPCTLARSFGVEWIASWLVVTVPTILGLLLT
uniprot
proteins
function
FUNCTION: Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including CD244/2B4 or CD2 to regulate immune cell function and activation (PubMed:12007789, PubMed:19494291, PubMed:27249817, PubMed:9841922). Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex (PubMed:19494291). In turn, promotes LCK phosphorylation and subsequent activation (PubMed:12007789). Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells (PubMed:27249817). {ECO:0000269|PubMed:12007789, ECO:0000269|PubMed:19494291, ECO:0000269|PubMed:27249817, ECO:0000269|PubMed:9841922}.
uniprot
proteins
mass_dalton
27683
uniprot
proteins
pubmed
12007789
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
1827826
uniprot
proteins
pubmed
1847502
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19494291
uniprot
proteins
pubmed
1999350
uniprot
proteins
pubmed
1999351
uniprot
proteins
pubmed
27249817
uniprot
proteins
pubmed
2828034
uniprot
proteins
pubmed
9041467
uniprot
proteins
pubmed
9418191
uniprot
proteins
pubmed
9841922
uniprot
proteins
pubmed
9893294
uniprot
proteins
sequence_length
243
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1999351, ECO:0000269|PubMed:9041467}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:1999351}. Membrane raft {ECO:0000269|PubMed:12007789}. Secreted {ECO:0000269|PubMed:9418191}.
uniprot
proteins