Lfng
entrez
16848
canonical
uniprot
O09010
canonical
ensembl
ENSMUSG00000029570
resolver
ensp
ENSMUSP00000031555
resolver
enst
ENSMUST00000031555
resolver
genesymbol
Lfng
resolver
uniprot
B2RRW2
resolver
uniprot
Q3U659
resolver
uniprot
Q8K3F1
resolver
uniprot
Q9DC10
resolver
uniprot_entry
B2RRW2_MOUSE
resolver
uniprot_entry
LFNG_MOUSE
resolver
uniprot_sec
Q3U659
resolver
uniprot_sec
Q8K3F1
resolver
uniprot_sec
Q9DC10
resolver
amino_acid_sequence
MLQRCGRRLLLALVGALLACLLVLTADPPPTPMPAERGRRALRSLAGSSGGAPASGSRAAVDPGVLTREVHSLSEYFSLLTRARRDADPPPGVASRQGDGHPRPPAEVLSPRDVFIAVKTTRKFHRARLDLLFETWISRHKEMTFIFTDGEDEALAKLTGNVVLTNCSSAHSRQALSCKMAVEYDRFIESGKKWFCHVDDDNYVNLRALLRLLASYPHTQDVYIGKPSLDRPIQATERISEHKVRPVHFWFATGGAGFCISRGLALKMGPWASGGHFMSTAERIRLPDDCTIGYIVEALLGVPLIRSGLFHSHLENLQQVPTTELHEQVTLSYGMFENKRNAVHIKGPFSVEADPSRFRSVHCHLYPDTPWCPRSAIF
uniprot
proteins
ec_number
2.4.1.222
uniprot
proteins
function
FUNCTION: Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules (PubMed:10935626). Modulates NOTCH1 activity by modifying O-fucose residues at specific EGF-like domains resulting in inhibition of NOTCH1 activation by JAG1 and enhancement of NOTCH1 activation by DLL1 via an increase in its binding to DLL1 (PubMed:16385447, PubMed:28089369). Decreases the binding of JAG1 to NOTCH2 but not that of DLL1 (By similarity). Essential mediator of somite segmentation and patterning. During somite boundary formation, it restricts Notch activity in the presomitic mesoderm to a boundary-forming territory in the posterior half of the prospective somite. In this region, Notch function activates a set of genes that are involved in boundary formation and in anterior-posterior somite identity (PubMed:10330372). Ectopically expressed in the thymus, Lfgn inhibits Notch signaling which results in inhibition of T-cell commitment and promotes B-cell development in lymphoid progenitors (PubMed:11520458). May play a role in boundary formation of the enamel knot (PubMed:12167404). {ECO:0000250|UniProtKB:Q8NES3, ECO:0000269|PubMed:10330372, ECO:0000269|PubMed:10935626, ECO:0000269|PubMed:11520458, ECO:0000269|PubMed:12167404, ECO:0000269|PubMed:16385447, ECO:0000269|PubMed:28089369}.
uniprot
proteins
mass_dalton
41952
uniprot
proteins
mutagenesis
MUTAGEN 187; /note="F->L: Unable to modulate Notch signaling in a cell-based assay. Loss of acetylglucosaminyltransferase activity. Does not localize to Golgi apparatus. No effect on protein expression."; /evidence="ECO:0000269|PubMed:16385447"; MUTAGEN 201; /note="D->A: Unable to modulate Notch signaling in a cell-based assay. Loss of acetylglucosaminyltransferase activity. Does not affect localization to Golgi apparatus. No effect on protein expression."; /evidence="ECO:0000269|PubMed:16385447
uniprot
proteins
post_translational_modification
PTM: A soluble form may be derived from the membrane form by proteolytic processing.
uniprot
proteins
protein_family
Glycosyltransferase 31 family
uniprot
proteins
pubmed
10330372
uniprot
proteins
pubmed
10341080
uniprot
proteins
pubmed
10935626
uniprot
proteins
pubmed
11520458
uniprot
proteins
pubmed
12110168
uniprot
proteins
pubmed
12110169
uniprot
proteins
pubmed
12167404
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16221665
uniprot
proteins
pubmed
16385447
uniprot
proteins
pubmed
28089369
uniprot
proteins
pubmed
9187150
uniprot
proteins
pubmed
9207795
uniprot
proteins
pubmed
9690473
uniprot
proteins
sequence_length
378
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:16385447}. Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins