Opalin
entrez
226115
canonical
uniprot
Q7M750
canonical
ensembl
ENSMUSG00000050121
resolver
ensp
ENSMUSP00000084422
resolver
enst
ENSMUST00000087176
resolver
genesymbol
Opalin
resolver
genesymbol_syn
Tmem10
resolver
uniprot
Q3USW3
resolver
uniprot
Q6P903
resolver
uniprot_entry
OPALI_MOUSE
resolver
uniprot_entry
Q3USW3_MOUSE
resolver
uniprot_sec
Q6P903
resolver
amino_acid_sequence
MSFSLNFTLPSNTTSSPVVTSAKATDCGPSIGLAAGIPSLLATALLVALLFTLIQRRRTIDDEPVEETEIPCEISELYDNPKISENPRRSPTHEMNPRGSQEGHIYVKTVSGSEEPLPDTYRPPEELERRRGLWWLVPSLSLE
uniprot
proteins
function
FUNCTION: Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation. {ECO:0000269|PubMed:30837646}.
uniprot
proteins
mass_dalton
15833
uniprot
proteins
mutagenesis
MUTAGEN 6; /note="N->Q: Impairs cell surface expression."; /evidence="ECO:0000269|PubMed:18490449"; MUTAGEN 12; /note="N->Q: Impairs cell surface expression."; /evidence="ECO:0000269|PubMed:18490449"; MUTAGEN 14; /note="T->A: Impairs cell surface expression."; /evidence="ECO:0000269|PubMed:18490449
uniprot
proteins
pubmed
11814680
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17442045
uniprot
proteins
pubmed
18439243
uniprot
proteins
pubmed
18490449
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27855200
uniprot
proteins
pubmed
30837646
uniprot
proteins
sequence_length
143
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18439243, ECO:0000269|PubMed:18490449, ECO:0000269|PubMed:30837646}; Single-pass type I membrane protein {ECO:0000255}. Note=In the CNS, enriched in the myelin paranodal and inner loop membranes, but not that of the PNS. Enriched in the leading edge of extending processes (PubMed:30837646). {ECO:0000269|PubMed:30837646}.
uniprot
proteins
transmembrane_region
TRANSMEM 31..51; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins