Tspyl2
entrez
52808
canonical
uniprot
Q7TQI8
canonical
ensembl
ENSMUSG00000041096
resolver
ensp
ENSMUSP00000046782
resolver
ensp
ENSMUSP00000162947
resolver
enst
ENSMUST00000044509
resolver
genesymbol
Tspyl2
resolver
genesymbol_syn
Cinap
resolver
genesymbol_syn
DXBwg1396e
resolver
genesymbol_syn
Dentt
resolver
genesymbol_syn
Tspx
resolver
uniprot
Q6WRI3
resolver
uniprot
Q9CU22
resolver
uniprot_entry
TSYL2_MOUSE
resolver
uniprot_sec
Q6WRI3
resolver
uniprot_sec
Q9CU22
resolver
amino_acid_sequence
MDRPDEGPPAKTPRLSSSEPRQRDLPPPPPPPLQRLPLPPPQQRPRPQEETEAAQVLADMRGVGPTLPPPLPYVILEEGGIRAYFTLSAESPGWDHAMESGFGEAPSTGIMETLPSSEISGGSLAIDFQVAEPSSLGEKALETCSLGGWGPQMLVGPKRKEEAIIIVEDEDEDDKESVRRRQRRRRRRRKQRKAKESRERSAQRMESILQALESIQMDLEAVNIKAGKAFLRLKRKFIQMRRPFLERRDLIIQHIPGFWVKAFLNHPRISILINQRDRDIFRYLTNLQVQDLRHISMGYKMKLYFQTNPYFTNMVIVKEFQRNRSGRLVSHSTPIRWHRGQEPQAYNRRSHDTRESFFNWFSNHSLPEADRIAEIIKNDLWVNPVRYYMRRGGYRSSRKKQHGKERAKNQYEMVIMEDAHDHYAIEDILSDISEIDEITDNETIHDIKISDFMETTDYFETTDNEVTDANENLCDSENPDHSEGYNTKITDNKGSVAANPDDNSDDPEEKNTYDSEDSNSEKADGDNTTLRDNQQVTNIQDSSDSDNGDEGSDDEDDDGNEGDNEGSDDDDDDNEGSDDDDRDIRYYKNGPEVFDKALDNRTNQNDYEEEVELISEDSVEEEEETSEEASQLSEDSYEDERIYGEERSEVNSEDSDIQEVLPVPKAWASLGKKGKIG
uniprot
proteins
function
FUNCTION: Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. {ECO:0000269|PubMed:15066269}.
uniprot
proteins
mass_dalton
77671
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-333 impairs function on cell proliferation. {ECO:0000250}.
uniprot
proteins
protein_family
Nucleosome assembly protein (NAP) family
uniprot
proteins
pubmed
12112471
uniprot
proteins
pubmed
12619135
uniprot
proteins
pubmed
15066269
uniprot
proteins
pubmed
15241014
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16374801
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
677
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note=Enriched in transcriptionally active regions of chromatin in neurons.
uniprot
proteins