GMNC
entrez
647309
canonical
uniprot
A6NCL1
canonical
ensembl
ENSG00000205835
resolver
ensp
ENSP00000406164
resolver
enst
ENST00000442080
resolver
genesymbol
GMNC
resolver
genesymbol_syn
GEMC1
resolver
hgnc
HGNC:40049
resolver
uniprot_entry
GEMC1_HUMAN
resolver
amino_acid_sequence
MNTILPCQDQYFVGGQSYNCPYSTTTSESSVDVSTETWVSFWAAGLLDNRELQQAPQAQESFSDSNFPLPDLCSWEEAQLSSQLYRNKQLQDTLVQKEEELARLHEENNHLRQYLNSALVKCLEEKAKKLLSSDEFSKAYGKFRKGKRKSKEQRYSPAEIPHPKNAKRNLSSEFANCEEQAGPPVDPWVLQTLGLKDLDTIDDTSSANYSALASHPRRVASTFSQFPDDAVDYKNIPREDMPIDYRGDRTTPLHSTATHGEDFHILSQLSNPPVGLKTLPYYTAHVSPNKTEMAFSTSLSPHCNVKTHSFHQGQAFVRRDEEGGWKFTWVPKQS
uniprot
proteins
function
FUNCTION: Regulator of DNA replication. Promotes initiation of chromosomal DNA replication by mediating TOPBP1- and CDK2-dependent recruitment of CDC45L onto replication origins (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
37887
uniprot
proteins
post_translational_modification
PTM: Highly phosphorylated by CDK2; stimulates initiation of DNA replication. {ECO:0000250}.
uniprot
proteins
protein_family
GEMC1 family
uniprot
proteins
pubmed
16641997
uniprot
proteins
sequence_length
334
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Associates with chromatin during pre-replication complex (pre-RC) formation. {ECO:0000250}.
uniprot
proteins