RFK
entrez
55312
canonical
uniprot
Q969G6
canonical
ensembl
ENSG00000135002
resolver
ensp
ENSP00000365926
resolver
enst
ENST00000376736
resolver
genesymbol
RFK
resolver
hgnc
HGNC:30324
resolver
uniprot
B2RDZ2
resolver
uniprot
Q5JSG9
resolver
uniprot
Q9NUT7
resolver
uniprot_entry
B2RDZ2_HUMAN
resolver
uniprot_entry
RIFK_HUMAN
resolver
uniprot_sec
Q5JSG9
resolver
uniprot_sec
Q9NUT7
resolver
amino_acid_sequence
MRHLPYFCRGQVVRGFGRGSKQLGIPTANFPEQVVDNLPADISTGIYYGWASVGSGDVHKMVVSIGWNPYYKNTKKSMETHIMHTFKEDFYGEILNVAIVGYLRPEKNFDSLESLISAIQGDIEEAKKRLELPEHLKIKEDNFFQVSKSKIMNGH
uniprot
proteins
ec_number
2.7.1.26
uniprot
proteins
function
FUNCTION: Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin-mononucleotide (FMN), hence rate-limiting enzyme in the synthesis of FAD. Essential for TNF-induced reactive oxygen species (ROS) production. Through its interaction with both TNFRSF1A and CYBA, physically and functionally couples TNFRSF1A to NADPH oxidase. TNF-activation of RFK may enhance the incorporation of FAD in NADPH oxidase, a critical step for the assembly and activation of NADPH oxidase. {ECO:0000269|PubMed:19641494}.
uniprot
proteins
mass_dalton
17623
uniprot
proteins
mutagenesis
MUTAGEN 79; /note="E->Q: Loss of riboflavin kinase activity. No effect on TNFRSF1A- and CYBA-binding."; /evidence="ECO:0000269|PubMed:19641494
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1. {ECO:0000269|PubMed:19641494}.
uniprot
proteins
pubmed
12623014
uniprot
proteins
pubmed
14580199
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19641494
uniprot
proteins
pubmed
21269460
uniprot
proteins
sequence_length
155
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins