DCST1
entrez
149095
canonical
uniprot
Q5T197
canonical
ensembl
ENSG00000163357
resolver
ensp
ENSP00000295542
resolver
ensp
ENSP00000387369
resolver
genesymbol
DCST1
resolver
hgnc
HGNC:26539
resolver
uniprot
B4DXA0
resolver
uniprot
B4DXB8
resolver
uniprot
B4DXE3
resolver
uniprot
E9PHV3
resolver
uniprot
Q5T198
resolver
uniprot
Q6P1W6
resolver
uniprot
Q71S70
resolver
uniprot
Q96M70
resolver
uniprot_entry
B4DXB8_HUMAN
resolver
uniprot_entry
B4DXE3_HUMAN
resolver
uniprot_entry
DCST1_HUMAN
resolver
uniprot_sec
B4DXA0
resolver
uniprot_sec
E9PHV3
resolver
uniprot_sec
Q5T198
resolver
uniprot_sec
Q6P1W6
resolver
uniprot_sec
Q71S70
resolver
uniprot_sec
Q96M70
resolver
amino_acid_sequence
MDIKHHQNGTRGQRRKQPHTTVQRLLTWGLPVSCSWFLWRQPGEFPVTALLLGAGAGGLLAIGLFQLLVNPMNIYEEQKIMFLYSLVGLGAMGWGTSPHIRCASLLLVPKMLGKEGRLFVLGYALAAIYVGPVANLRHNLNNVIASLGCTVELQINNTRAAWRISTAPLRAMFKDLLSSKELLRAETRNISATFEDLDAQVNSETGYTPEDTMDSGETAQGREARQAPASRLHLSTQKMYELKTKLRCSYVVNQAILSCRRWFDRKHEQCMKHIWVPLLTHLLCLPMKFKFFCGIAKVMEVWCRNRIPVEGNFGQTYDSLNQSIRGLDGEFSANIDFKEEKQAGVLGLNTSWERVSTEVRDYVYRQEARLEWALGLLHVLLSCTFLLVLHASFSYMDSYNHDIRFDNIYISTYFCQIDDRRKKLGKRTLLPLRKAEEKTVIFPCKPTIQASEMSNVVRELLETLPILLLLVVLCGLDWALYSIFDTIRHHSFLQYSFRSSHKLEVKVGGDSMLARLLRKTIGALNTSSETVMESNNMPCLPQPVGLDARAYWRAAVPIGLLVCLCLLQAFGYRLRRVIAAFYFPKREKKRILFLYNDLLKKRAAFTKLRRAAILRRERQQKAPRHPLADILHRGCPLLRRWLCRRCVVCQAPETPESYVCRTLDCEAVYCWSCWDDMRQRCPVCTPREELSSSAFSDSNDDTAYAG
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase which mediates 'Lys-48'-linked ubiquitination of STAT2 and induces its proteasomal degradation thereby negatively regulating type-I-interferon signaling. Essential sperm cell-surface protein required for sperm-egg fusion and fertilization (By similarity). {ECO:0000250|UniProtKB:Q059Y8, ECO:0000269|PubMed:27782195}.
uniprot
proteins
mass_dalton
80712
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:27782195}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
27782195
uniprot
proteins
sequence_length
706
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27782195}; Multi-pass membrane protein {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:Q059Y8}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes in the anterior acrosome before the acrosome reaction and then translocates to the equatorial segment in acrosome-reacted sperm. {ECO:0000250|UniProtKB:Q059Y8}.
uniprot
proteins
transmembrane_region
TRANSMEM 49..69; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 80..100; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 116..136; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 373..393; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 464..484; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 554..574; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins