CLIC4
entrez
25932
canonical
uniprot
Q9Y696
canonical
ensembl
ENSG00000169504
resolver
ensp
ENSP00000363500
resolver
ensp
ENSP00000436538
resolver
enst
ENST00000374379
resolver
enst
ENST00000488683
resolver
genesymbol
CLIC4
resolver
hgnc
HGNC:13518
resolver
uniprot
A0A024RAH9
resolver
uniprot
Q6FIC5
resolver
uniprot
Q9UFW9
resolver
uniprot
Q9UQJ6
resolver
uniprot_entry
CLIC4_HUMAN
resolver
uniprot_entry
Q6FIC5_HUMAN
resolver
uniprot_sec
A0A024RAH9
resolver
uniprot_sec
Q9UFW9
resolver
uniprot_sec
Q9UQJ6
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by rapamycin, amphotericin B and IAA-94. {ECO:0000269|PubMed:37759794}.
uniprot
proteins
amino_acid_sequence
MALSMPLNGLKEEDKEPLIELFVKAGSDGESIGNCPFSQRLFMILWLKGVVFSVTTVDLKRKPADLQNLAPGTHPPFITFNSEVKTDVNKIEEFLEEVLCPPKYLKLSPKHPESNTAGMDIFAKFSAYIKNSRPEANEALERGLLKTLQKLDEYLNSPLPDEIDENSMEDIKFSTRKFLDGNEMTLADCNLLPKLHIVKVVAKKYRNFDIPKEMTGIWRYLTNAYSRDEFTNTCPSDKEVEIAYSDVAKRLTK
uniprot
proteins
ec_number
1.8.-.-
uniprot
proteins
function
FUNCTION: In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (PubMed:25581026, PubMed:37759794). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions (By similarity) (PubMed:16176272). Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Promotes cell-surface expression of HRH3. {ECO:0000250|UniProtKB:Q9Z0W7, ECO:0000269|PubMed:12163372, ECO:0000269|PubMed:14569596, ECO:0000269|PubMed:16176272, ECO:0000269|PubMed:16239224, ECO:0000269|PubMed:18302930, ECO:0000269|PubMed:19247789, ECO:0000269|PubMed:25581026, ECO:0000269|PubMed:37759794}.
uniprot
proteins
mass_dalton
28772
uniprot
proteins
protein_family
Chloride channel CLIC family
uniprot
proteins
pubmed
10070163
uniprot
proteins
pubmed
10191309
uniprot
proteins
pubmed
10793131
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12163372
uniprot
proteins
pubmed
12163479
uniprot
proteins
pubmed
14569596
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16176272
uniprot
proteins
pubmed
16239224
uniprot
proteins
pubmed
16581025
uniprot
proteins
pubmed
17200346
uniprot
proteins
pubmed
17636002
uniprot
proteins
pubmed
18302930
uniprot
proteins
pubmed
19247789
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25581026
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
37759794
uniprot
proteins
sequence_length
253
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14569596}. Cytoplasmic vesicle membrane {ECO:0000305|PubMed:17636002}; Single-pass membrane protein {ECO:0000305}. Nucleus {ECO:0000305|PubMed:17636002}. Cell membrane {ECO:0000269|PubMed:18302930}; Single-pass membrane protein {ECO:0000305}. Mitochondrion {ECO:0000250|UniProtKB:Q9Z0W7}. Cell junction {ECO:0000269|PubMed:14569596}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Z0W7}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9Z0W7}. Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles. Might not be present in the nucleus of cardiac cells. {ECO:0000250|UniProtKB:Q9Z0W7, ECO:0000269|PubMed:14569596}.
uniprot
proteins
transmembrane_region
TRANSMEM 37..57; /note="Helical; Note=After insertion into the membrane"; /evidence="ECO:0000250|UniProtKB:Q9Z0W7
uniprot
proteins