Rab3d
entrez
19340
canonical
uniprot
P35276
canonical
ensembl
ENSMUSG00000019066
resolver
ensp
ENSMUSP00000111008
resolver
ensp
ENSMUSP00000113322
resolver
ensp
ENSMUSP00000191857
resolver
ensp
ENSMUSP00000191862
resolver
enst
ENSMUST00000115351
resolver
enst
ENSMUST00000122211
resolver
genesymbol
Rab3d
resolver
genesymbol_syn
Rab3D
resolver
uniprot
Q543Q4
resolver
uniprot_entry
Q543Q4_MOUSE
resolver
uniprot_entry
RAB3D_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs) which prevent Rab-GDP dissociation. {ECO:0000250|UniProtKB:P20336}.
uniprot
proteins
amino_acid_sequence
MASASEPPASPRDAADQNFDYMFKLLLIGNSSVGKTSFLFRYADDSFTPAFVSTVGIDFKVKTVYRHDKRIKLQIWDTAGQERYRTITTAYYRGAMGFLLMYDIANQESFTAVQDWATQIKTYSWDNAQVILVGNKCDLEDERVVPAEDGRRLADDLGFEFFEASAKENINVKQVFERLVDIICDKMNESLEPSSSPGSNGKGPALGDTPPPQPSSCSC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB3D may be involved in the insulin-induced exocytosis of GLUT4-containing vesicles in adipocytes (PubMed:1594612). {ECO:0000250|UniProtKB:P20336, ECO:0000269|PubMed:1594612}.
uniprot
proteins
mass_dalton
24416
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Thr-86 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM and CHML. {ECO:0000250|UniProtKB:O95716}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10891340
uniprot
proteins
pubmed
11431472
uniprot
proteins
pubmed
12578829
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1594612
uniprot
proteins
pubmed
18849981
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29125462
uniprot
proteins
sequence_length
219
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
uniprot
proteins