DCAF7
entrez
10238
canonical
uniprot
P61962
canonical
ensembl
ENSG00000136485
resolver
ensembl
ENSG00000288894
resolver
ensp
ENSP00000483236
resolver
genesymbol
DCAF7
resolver
genesymbol_syn
HAN11
resolver
genesymbol_syn
WDR68
resolver
hgnc
HGNC:30915
resolver
uniprot
B4E039
resolver
uniprot
D3DU14
resolver
uniprot
O15491
resolver
uniprot
Q9DAE4
resolver
uniprot_entry
DCAF7_HUMAN
resolver
uniprot_sec
B4E039
resolver
uniprot_sec
D3DU14
resolver
uniprot_sec
O15491
resolver
uniprot_sec
Q9DAE4
resolver
amino_acid_sequence
MSLHGKRKEIYKYEAPWTVYAMNWSVRPDKRFRLALGSFVEEYNNKVQLVGLDEESSEFICRNTFDHPYPTTKLMWIPDTKGVYPDLLATSGDYLRVWRVGETETRLECLLNNNKNSDFCAPLTSFDWNEVDPYLLGTSSIDTTCTIWGLETGQVLGRVNLVSGHVKTQLIAHDKEVYDIAFSRAGGGRDMFASVGADGSVRMFDLRHLEHSTIIYEDPQHHPLLRLCWNKQDPNYLATMAMDGMEVVILDVRVPCTPVARLNNHRACVNGIAWAPHSSCHICTAADDHQALIWDIQQMPRAIEDPILAYTAEGEINNVQWASTQPDWIAICYNNCLEILRV
uniprot
proteins
function
FUNCTION: Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches (By similarity). Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in normal and disease skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. {ECO:0000250, ECO:0000269|PubMed:16887337, ECO:0000269|PubMed:16949367}.
uniprot
proteins
mass_dalton
38926
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
WD repeat DCAF7 family
uniprot
proteins
pubmed
14593110
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16887337
uniprot
proteins
pubmed
16949367
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21328542
uniprot
proteins
pubmed
23864635
uniprot
proteins
pubmed
9192870
uniprot
proteins
sequence_length
342
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Overexpression of DIAHP1 or active RHOA causes translocation from the nucleus to cytoplasm.
uniprot
proteins