Mif
entrez
17319
canonical
uniprot
P34884
canonical
ensembl
ENSMUSG00000033307
resolver
ensp
ENSMUSP00000041149
resolver
enst
ENSMUST00000038169
resolver
genesymbol
Mif
resolver
uniprot
Q545F0
resolver
uniprot_entry
MIF_MOUSE
resolver
uniprot_entry
Q545F0_MOUSE
resolver
amino_acid_sequence
MPMFIVNTNVPRASVPEGFLSELTQQLAQATGKPAQYIAVHVVPDQLMTFSGTNDPCALCSLHSIGKIGGAQNRNYSKLLCGLLSDRLHISPDRVYINYYDMNAANVGWNGSTFA
uniprot
proteins
ec_number
5.3.2.1
uniprot
proteins
ec_number
5.3.3.12
uniprot
proteins
function
FUNCTION: Pro-inflammatory cytokine involved in the innate immune response to bacterial pathogens (By similarity). The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense (By similarity). Counteracts the anti-inflammatory activity of glucocorticoids (By similarity). Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known (PubMed:10933783, PubMed:16780921, PubMed:19188446). It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (PubMed:10933783, PubMed:16780921, PubMed:19188446). {ECO:0000250|UniProtKB:P14174, ECO:0000269|PubMed:10933783, ECO:0000269|PubMed:16780921, ECO:0000269|PubMed:19188446}.
uniprot
proteins
mass_dalton
12504
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="P->G: Loss of tautomerase activity, reduced activation of intracellular signaling pathways, and reduced interaction with CXCR2 and COPS5."; /evidence="ECO:0000269|PubMed:10933783, ECO:0000269|PubMed:19188446
uniprot
proteins
protein_family
MIF family
uniprot
proteins
pubmed
10360941
uniprot
proteins
pubmed
10933783
uniprot
proteins
pubmed
1508193
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16780921
uniprot
proteins
pubmed
17526494
uniprot
proteins
pubmed
19188446
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
7558020
uniprot
proteins
pubmed
7558021
uniprot
proteins
pubmed
7679497
uniprot
proteins
pubmed
7706726
uniprot
proteins
pubmed
7947826
uniprot
proteins
pubmed
8234256
uniprot
proteins
pubmed
8413654
uniprot
proteins
sequence_length
115
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:8234256}. Cytoplasm {ECO:0000250|UniProtKB:P14174}. Note=Does not have a cleavable signal sequence and is secreted via a specialized, non-classical pathway. Secreted by macrophages upon stimulation by bacterial lipopolysaccharide (LPS), or by M.tuberculosis antigens (By similarity). {ECO:0000250|UniProtKB:P14174}.
uniprot
proteins