SLFN13
entrez
146857
canonical
uniprot
Q68D06
canonical
ensembl
ENSG00000154760
resolver
ensp
ENSP00000285013
resolver
ensp
ENSP00000434439
resolver
ensp
ENSP00000435442
resolver
ensp
ENSP00000525142
resolver
ensp
ENSP00000525143
resolver
ensp
ENSP00000525144
resolver
genesymbol
SLFN13
resolver
hgnc
HGNC:26481
resolver
uniprot
E1P645
resolver
uniprot
Q658M1
resolver
uniprot
Q6ZS51
resolver
uniprot
Q96A81
resolver
uniprot_entry
SLN13_HUMAN
resolver
uniprot_sec
E1P645
resolver
uniprot_sec
Q658M1
resolver
uniprot_sec
Q6ZS51
resolver
uniprot_sec
Q96A81
resolver
amino_acid_sequence
MEANHCSLGVYPSYPDLVIDVGEVTLGEENRKKLQKTQRDQERARVIRAACALLNSGGGVIQMEMANRDERPTEMGLDLEESLRKLIQYPYLQAFFETKQHGRCFYIFVKSWSGDPFLKDGSFNSRICSLSSSLYCRSGTSVLHMNSRQAFDFLKTKERQSKYNLINEGSPPSKIMKAVYQNISESNPAYEVFQTDTIEYGEILSFPESPSIEFKQFSTKHIQQYVENIIPEYISAFANTEGGYLFIGVDDKSRKVLGCAKEQVDPDSLKNVIARAISKLPIVHFCSSKPRVEYSTKIVEVFCGKELYGYLCVIKVKAFCCVVFSEAPKSWMVREKYIRPLTTEEWVEKMMDADPEFPPDFAEAFESQLSLSDSPSLCRPVYSKKGLEHKADLQQHLFPVPPGHLECTPESLWKELSLQHEGLKELIHKQMRPFSQGIVILSRSWAVDLNLQEKPGVICDALLIAQNSTPILYTILREQDAEGQDYCTRTAFTLKQKLVNMGGYTGKVCVRAKVLCLSPESSAEALEAAVSPMDYPASYSLAGTQHMEALLQSLVIVLLGFRSLLSDQLGCEVLNLLTAQQYEIFSRSLRKNRELFVHGLPGSGKTIMAMKIMEKIRNVFHCEAHRILYVCENQPLRNFISDRNICRAETRETFLREKFEHIQHIVIDEAQNFRTEDGDWYRKAKTITQREKDCPGVLWIFLDYFQTSHLGHSGLPPLSAQYPREELTRVVRNADEIAEYIQQEMQLIIENPPINIPHGYLAILSEAKWVPGVPGNTKIIKNFTLEQIVTYVADTCRCFFERGYSPKDVAVLVSTVTEVEQYQSKLLKAMRKKMVVQLSDACDMLGVHIVLDSVRRFSGLERSIVFGIHPRTADPAILPNILICLASRAKQHLYIFL
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: Endoribonuclease that cleaves tRNAs and rRNAs (PubMed:29563550). Cleaves tRNAs 11 nucleotides from the 3'-terminus at the acceptor stem (PubMed:29563550). Does not act on tRNA(Sec) (PubMed:29563550). Able to restrict HIV-1 virus replication; ability to inhibit HIV-1 replication is dependent on endoribonuclease activity (PubMed:29563550). {ECO:0000269|PubMed:29563550}.
uniprot
proteins
mass_dalton
102045
uniprot
proteins
mutagenesis
MUTAGEN 208; /note="E->A: Abolished endoribonuclease activity."; /evidence="ECO:0000269|PubMed:29563550"; MUTAGEN 213; /note="E->A: Abolished endoribonuclease activity."; /evidence="ECO:0000269|PubMed:29563550"; MUTAGEN 251; /note="D->A: Reduced endoribonuclease activity."; /evidence="ECO:0000269|PubMed:29563550
uniprot
proteins
protein_family
Schlafen family
uniprot
proteins
protein_family
Subgroup III subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
29563550
uniprot
proteins
sequence_length
897
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:29563550}.
uniprot
proteins