Spty2d1
entrez
101685
canonical
uniprot
Q68FG3
canonical
ensembl
ENSMUSG00000049516
resolver
ensp
ENSMUSP00000059457
resolver
enst
ENSMUST00000061639
resolver
genesymbol
Spty2d1
resolver
uniprot
Q8BIR1
resolver
uniprot_entry
SPT2_MOUSE
resolver
uniprot_sec
Q8BIR1
resolver
amino_acid_sequence
MDFREILLIASKGQGVNHVPKRYSLAVGPPKKDPKVKGVQSAAVQAFLRRKEEELRQKALEEKKRKEELVKKRIELKHDKKARAMAKRTKDNFHGYDGIPVEEKTKKKQLVESHLNQGTDQEYDVEEEDFIDYNQAELDQDYEEEQEPPKAESKPKAPLKSAPSPMNFTDLLRLAEKKQFEPVEIKVVKKAEDRPLTAEELREREFLERKHRKKKPEPDAKLPPPVLKKAPSHKDIMGTKPSRGAGDRQLASKGLPFPQAEKKFRPSTASEKQAALSSPKSLPGERTKVGSGSSTQPSLREGHNRPVFNGAGKPRPSTCSPSVPKTPASGTQKSASEHKAKKPLPSHPSHSKPGPTVLSHNKSKSPGVRQPGSNSGSAPGQPNPGTARPTLSSGPVPRRQNGSSSSGPEQSAGGIRKLASNSHLSGRTLNGTNGPGRPASSSSGPGRPISGSAGSGRPVGSSGGPGQPVNNPHDLRRPMNSLSSPGRAVSGPGRSISGSIPAGRTVNSGPGRPVSSLGPGRAVSNPGLPTKPRCTVVSETISSKNIISRSSNGQINGMKPLLSGYRSAQGPQRLPFPTGYKRPREYEEDDDDEYDSEMDDFIEDEGEPQEEISKHIREIFGYDRKKYKDESDYALRYMESSWKEQQKEEAKSLRLGMQEDLEEMRREEEELKRRKAKKLKRH
uniprot
proteins
function
FUNCTION: Histone chaperone that stabilizes pre-existing histone tetramers and regulates replication-independent histone exchange on chromatin. Required for normal chromatin refolding in the coding region of transcribed genes, and for the suppression of spurious transcription. Binds DNA and histones and promotes nucleosome assembly (in vitro). Facilitates formation of tetrameric histone complexes containing histone H3 and H4 (By similarity). Modulates RNA polymerase 1-mediated transcription (By similarity). Binds DNA, with a preference for branched DNA species, such as Y-form DNA and Holliday junction DNA (By similarity). {ECO:0000250|UniProtKB:E1BUG7, ECO:0000250|UniProtKB:Q68D10}.
uniprot
proteins
mass_dalton
74818
uniprot
proteins
protein_family
SPT2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
682
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:E1BUG7}.
uniprot
proteins