Jtb
entrez
29439
canonical
uniprot
O88823
canonical
ensembl
ENSRNOG00000016379
resolver
ensembl
ENSRNOG00055021887
resolver
ensembl
ENSRNOG00060029920
resolver
ensembl
ENSRNOG00065028758
resolver
ensp
ENSRNOP00000091899
resolver
ensp
ENSRNOP00055030636
resolver
ensp
ENSRNOP00060043239
resolver
ensp
ENSRNOP00065040741
resolver
enst
ENSRNOT00000104641
resolver
enst
ENSRNOT00055037560
resolver
enst
ENSRNOT00060051988
resolver
enst
ENSRNOT00065049626
resolver
genesymbol
Jtb
resolver
uniprot_entry
JTB_RAT
resolver
amino_acid_sequence
MLVGAGRRGLPRGGHLCWLLCAFTLKLCEAEAPVREEKLSVSTSTSPCWLVEEFVVTEECTPCSNFQIKTTPECGSTGYVEKITCSSSKRNEFKSCRSALLEQHLFWKFEGIVVGVALVFACLVIIRQRQLDRKALEKVRKQIESI
uniprot
proteins
function
FUNCTION: Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1. Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
16385
uniprot
proteins
protein_family
JTB family
uniprot
proteins
pubmed
10321732
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
146
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Mitochondrion {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase (By similarity). {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 106..126; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins