Gap43
entrez
14432
canonical
uniprot
P06837
canonical
ensembl
ENSMUSG00000047261
resolver
ensp
ENSMUSP00000099881
resolver
enst
ENSMUST00000102817
resolver
genesymbol
Gap43
resolver
genesymbol_syn
Basp2
resolver
uniprot_entry
NEUM_MOUSE
resolver
amino_acid_sequence
MLCCMRRTKQVEKNDEDQKIEQDGVKPEDKAHKAATKIQASFRGHITRKKLKGEKKGDAPAAEAEAKEKDDAPVADGVEKKEGDGSATTDAAPATSPKAEEPSKAGDAPSEEKKGEGDAAPSEEKAGSAETESAAKATTDNSPSSKAEDGPAKEEPKQADVPAAVTDAAATTPAAEDAATKAAQPPTETAESSQAEEEKDAVDEAKPKESARQDEGKEDPEADQEHA
uniprot
proteins
function
FUNCTION: This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. {ECO:0000250|UniProtKB:P17677}.
uniprot
proteins
mass_dalton
23632
uniprot
proteins
mutagenesis
MUTAGEN 3; /note="C->S: Loss of palmitoylation; when associated with S-4."; /evidence="ECO:0000269|PubMed:27875292"; MUTAGEN 4; /note="C->S: Loss of palmitoylation; when associated with S-3."; /evidence="ECO:0000269|PubMed:27875292
uniprot
proteins
post_translational_modification
PTM: Phosphorylated (PubMed:18493953). Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity (By similarity). {ECO:0000250|UniProtKB:P07936, ECO:0000269|PubMed:18493953}.; PTM: Palmitoylated by ZDHHC3 (PubMed:27875292). Palmitoylation is regulated by ARF6 and is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2 (By similarity). {ECO:0000250|UniProtKB:P17677, ECO:0000269|PubMed:27875292}.
uniprot
proteins
protein_family
Neuromodulin family
uniprot
proteins
pubmed
11433297
uniprot
proteins
pubmed
11573004
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
18493953
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2442159
uniprot
proteins
pubmed
27875292
uniprot
proteins
pubmed
28111162
uniprot
proteins
sequence_length
227
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P17677}; Peripheral membrane protein {ECO:0000250|UniProtKB:P17677}; Cytoplasmic side {ECO:0000250|UniProtKB:P17677}. Cell projection, growth cone membrane {ECO:0000250|UniProtKB:P17677}; Peripheral membrane protein {ECO:0000250|UniProtKB:P17677}; Cytoplasmic side {ECO:0000250|UniProtKB:P17677}. Synapse {ECO:0000250|UniProtKB:P17677}. Cell projection, filopodium membrane {ECO:0000250|UniProtKB:P17677}; Peripheral membrane protein {ECO:0000250|UniProtKB:P17677}. Perikaryon {ECO:0000250|UniProtKB:P07936}. Cell projection, dendrite {ECO:0000250|UniProtKB:P07936}. Cell projection, axon {ECO:0000250|UniProtKB:P07936}. Cytoplasm {ECO:0000250|UniProtKB:P07936}. Note=Cytoplasmic surface of growth cone and synaptic plasma membranes. {ECO:0000250|UniProtKB:P17677}.
uniprot
proteins