Smyd5
entrez
232187
canonical
uniprot
Q3TYX3
canonical
ensembl
ENSMUSG00000033706
resolver
ensp
ENSMUSP00000048537
resolver
enst
ENSMUST00000045693
resolver
genesymbol
Smyd5
resolver
genesymbol_syn
Rai15
resolver
uniprot
Q3TRB2
resolver
uniprot
Q91YL6
resolver
uniprot_entry
SMYD5_MOUSE
resolver
uniprot_sec
Q3TRB2
resolver
uniprot_sec
Q91YL6
resolver
amino_acid_sequence
MAASMCDVFSFCVGVADRARGSVEVRYVDSIKGKGLFATQLIRKGETIFIERPLVAAQFLWNALYQYRACDHCLRALEKAEENAQRLTGKPSQILPHPELCSVRKDLHQNCPHCQVMYCSAECRLAAAEQYHQILCPGPSHDPRHPLNKLQEAWRSVHYPPETASIMLMARMVATVKQAKDKDHWVRLFNHFCSRTANQEQAIVHKLLKGKFKDQLELLLGLFKEALYEEALSLWFTPEGFRSLFALVGTNGQGIGTSSLSQWVHACDALELTPQDREQLDTFIDQLYKDIEAATGEFLNCEGSGLFVLQSCCNHSCVPNAETSFPENNFVLHVTALEDIKPGEEICISYLDCCQRERSRHSRHKILRENYLFNCSCPKCLAEADDPNVTSEEEEEEDEEEGEPEDAELGDEMTDV
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
ec_number
2.1.1.359
uniprot
proteins
ec_number
2.1.1.372
uniprot
proteins
function
FUNCTION: Protein-lysine N-trimethyltransferase that specifically catalyzes trimethylation of 'Lys-22' of the RPL40/eL40 subunit of the 60S ribosome, thereby promoting translation elongation and protein synthesis (By similarity). May also act as a histone methyltransferase in the context of histone octamers, but not on nucleosome substrates: trimethylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4 to form H3K36me3 and H4K20me3, respectively (PubMed:22921934, PubMed:28250819, PubMed:35680905, PubMed:39083378). The histone methyltransferase activity, which is independent of its SET domain, is however unsure in vivo (By similarity). In association with the NCoR corepressor complex, involved in the repression of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages, possibly by catalyzing the formation of H4K20me3 at the gene promoters (PubMed:22921934). Plays an important role in embryonic stem (ES) cell self-renewal and differentiation (PubMed:28951459). Maintains genome stability of ES cells during differentiation through regulation of heterochromatin formation and repression of endogenous repetitive DNA elements by promoting H4K20me3 marks (PubMed:28250819). Acts as a regulator of the hypothermia response: its degradation in response to mild hypothermia relieves the formation of H3K36me3 at gene promoters, allowing expression of the neuroprotective gene SP1 (PubMed:39083378). {ECO:0000250|UniProtKB:Q6GMV2, ECO:0000269|PubMed:22921934, ECO:0000269|PubMed:28250819, ECO:0000269|PubMed:28951459, ECO:0000269|PubMed:35680905, ECO:0000269|PubMed:39083378}.
uniprot
proteins
mass_dalton
47095
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated and degradaed by the proteasome in response to mild hypothermia (32 degrees Celsius), relieving repression of the SP1 gene. {ECO:0000269|PubMed:39083378}.
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22921934
uniprot
proteins
pubmed
28250819
uniprot
proteins
pubmed
28951459
uniprot
proteins
pubmed
35680905
uniprot
proteins
pubmed
39048817
uniprot
proteins
pubmed
39083378
uniprot
proteins
pubmed
39103523
uniprot
proteins
pubmed
8754834
uniprot
proteins
sequence_length
416
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6GMV2}.
uniprot
proteins