Sass6
entrez
72776
canonical
uniprot
Q80UK7
canonical
ensembl
ENSMUSG00000027959
resolver
ensp
ENSMUSP00000143123
resolver
ensp
ENSMUSP00000143233
resolver
ensp
ENSMUSP00000287512
resolver
ensp
ENSMUSP00000287513
resolver
ensp
ENSMUSP00000287515
resolver
enst
ENSMUST00000197335
resolver
genesymbol
Sass6
resolver
genesymbol_syn
Sas6
resolver
uniprot
A0A0G2JFC9
resolver
uniprot
Q9CYT4
resolver
uniprot_entry
A0A0G2JFC9_MOUSE
resolver
uniprot_entry
SAS6_MOUSE
resolver
uniprot_sec
Q9CYT4
resolver
amino_acid_sequence
MSQVLFQQLVPLLVKCKDCEERRGSVRVSIELQSLSNPVHRKDLVIRLTDDTDPFFLYNLVISEEDFQSLKLQQGLLVDFLAFPQKFIDLLQQCMQEHAKETPRFLLQLLSSATLLENSPVLLNVVETNPFKHLIHLSLKLLPGNDVEIKKFLAGCLKCSKEEKLSLTRSLDDVTRQLHITQETLSEKMQELDKLRSEWASHTASLTNKHSQELTAEKEKALQTQVQCQQQHEQQKKELETLHQRNIHQLQSRLSELEAANKELTERKYKGDSTVRELKAKLAGVEEELQRAKQEVLSLRRENCTLDTECHEKEKHINQLQTKVAVLEQEIKDKDQLVLRTKEAFDTIQEQKVALEENGEKNQIQLGKLEATIKSLSAELLKANEIIKKLQGDLKTLMGKLKLKNTVTIQQEKLLAEKEEMLQKERKESQDAGQFLRAKEQEVCRLQEQLETTVQKLEESKQLLKNNEKLITWLNKELNENQLVRKQDTLGTSATPHSTSNSTIRSGLSPNLNVVDRLNYPSCGIGYPVSSALTFQNAFPHVVAAKNTSHPISGPKVHFNLQLTKPSASIDGQPGAAVNRPCSNDKENGETLGLESKYLKRREASIPLRGLSQNLLSDSDHQKDGMLGAFQLSSKPTVLPSSSSAYFPGQLPSS
uniprot
proteins
function
FUNCTION: Central scaffolding component of the centrioles ensuring their 9-fold symmetry (By similarity). Required for centrosome biogenesis and duplication (PubMed:24240477, PubMed:38407237). Required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells (PubMed:24240477). Not required for centriole formation in embryonic stem cells but necessary to maintain centriole architecture (PubMed:38407237). Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification (By similarity). {ECO:0000250|UniProtKB:Q6UVJ0, ECO:0000250|UniProtKB:Q7ZVT3, ECO:0000269|PubMed:24240477, ECO:0000269|PubMed:38407237}.
uniprot
proteins
mass_dalton
74054
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the SCF(FBXW5) E3 ubiquitin-protein ligase complex during S phase, leading to its degradation and preventing centriole reduplication. Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex, leading to its degradation and preventing centriole reduplication. {ECO:0000250|UniProtKB:Q6UVJ0}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
24240477
uniprot
proteins
pubmed
38407237
uniprot
proteins
sequence_length
654
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:38407237}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:24240477, ECO:0000269|PubMed:38407237}. Note=Component of the centrosome. Associated only transiently with nascent procentrioles during centriole biogenesis (By similarity). Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles (PubMed:24240477). {ECO:0000250|UniProtKB:Q6UVJ0, ECO:0000269|PubMed:24240477}.
uniprot
proteins