SNX1
entrez
6642
canonical
uniprot
Q13596
canonical
ensembl
ENSG00000028528
resolver
ensp
ENSP00000261889
resolver
ensp
ENSP00000453567
resolver
ensp
ENSP00000453785
resolver
genesymbol
SNX1
resolver
hgnc
HGNC:11172
resolver
uniprot
A6NM19
resolver
uniprot
A8K6T7
resolver
uniprot
H0Y2M5
resolver
uniprot
O60750
resolver
uniprot
O60751
resolver
uniprot
Q6ZRJ8
resolver
uniprot_entry
SNX1_HUMAN
resolver
uniprot_sec
A6NM19
resolver
uniprot_sec
A8K6T7
resolver
uniprot_sec
H0Y2M5
resolver
uniprot_sec
O60750
resolver
uniprot_sec
O60751
resolver
uniprot_sec
Q6ZRJ8
resolver
amino_acid_sequence
MASGGGGCSASERLPPPFPGLEPESEGAAGGSEPEAGDSDTEGEDIFTGAAVVSKHQSPKITTSLLPINNGSKENGIHEEQDQEPQDLFADATVELSLDSTQNNQKKVLAKTLISLPPQEATNSSKPQPTYEELEEEEQEDQFDLTVGITDPEKIGDGMNAYVAYKVTTQTSLPLFRSKQFAVKRRFSDFLGLYEKLSEKHSQNGFIVPPPPEKSLIGMTKVKVGKEDSSSAEFLEKRRAALERYLQRIVNHPTMLQDPDVREFLEKEELPRAVGTQTLSGAGLLKMFNKATDAVSKMTIKMNESDIWFEEKLQEVECEEQRLRKLHAVVETLVNHRKELALNTAQFAKSLAMLGSSEDNTALSRALSQLAEVEEKIEQLHQEQANNDFFLLAELLSDYIRLLAIVRAAFDQRMKTWQRWQDAQATLQKKREAEARLLWANKPDKLQQAKDEILEWESRVTQYERDFERISTVVRKEVIRFEKEKSKDFKNHVIKYLETLLYSQQQLAKYWEAFLPEAKAIS
uniprot
proteins
function
FUNCTION: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17101778, PubMed:17550970, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation; the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498). {ECO:0000269|PubMed:12198132, ECO:0000269|PubMed:15498486, ECO:0000269|PubMed:16407403, ECO:0000269|PubMed:17101778, ECO:0000269|PubMed:17550970, ECO:0000269|PubMed:18088323, ECO:0000269|PubMed:19816406, ECO:0000269|PubMed:20070609, ECO:0000269|PubMed:20604901, ECO:0000269|PubMed:21040701, ECO:0000269|PubMed:23085988, ECO:0000269|PubMed:23152498, ECO:0000303|PubMed:15498486}.
uniprot
proteins
mass_dalton
59070
uniprot
proteins
mutagenesis
MUTAGEN 214; /note="K->A: Abolishes phosphatidylinositol phosphate binding. Abolishes endosomal location."; /evidence="ECO:0000269|PubMed:12198132, ECO:0000269|PubMed:15498486"; MUTAGEN 287..288; /note="MF->EE: Abolishes membrane remodeling capacity; no effect on dimerization."; /evidence="ECO:0000269|PubMed:23085988"; MUTAGEN 429..431; /note="KKR->EEE: Loss of endosomal location."; /evidence="ECO:0000269|PubMed:15498486"; MUTAGEN 442; /note="K->A: No effect on membrane remodeling and membrane binding; when associated with A-445."; /evidence="ECO:0000269|PubMed:23085988"; MUTAGEN 445; /note="K->A: No effect on membrane remodeling and membrane binding; when associated with A-442."; /evidence="ECO:0000269|PubMed:23085988
uniprot
proteins
protein_family
Sorting nexin family
uniprot
proteins
pubmed
11102511
uniprot
proteins
pubmed
11997453
uniprot
proteins
pubmed
12198132
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498486
uniprot
proteins
pubmed
15673616
uniprot
proteins
pubmed
16407403
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17101778
uniprot
proteins
pubmed
17550970
uniprot
proteins
pubmed
18088323
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19619496
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19816406
uniprot
proteins
pubmed
19874558
uniprot
proteins
pubmed
19935774
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20070609
uniprot
proteins
pubmed
20604901
uniprot
proteins
pubmed
21040701
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22431521
uniprot
proteins
pubmed
23085988
uniprot
proteins
pubmed
23152498
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
37158588
uniprot
proteins
pubmed
39073202
uniprot
proteins
pubmed
8638121
uniprot
proteins
pubmed
9819414
uniprot
proteins
sequence_length
522
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:15498486, ECO:0000269|PubMed:18088323, ECO:0000269|PubMed:22431521}; Peripheral membrane protein; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium {ECO:0000269|PubMed:20604901}. Note=Enriched on tubular elements of the early endosome membrane. Binds preferentially to highly curved membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:15498486). Colocalized with SORT1 to tubular endosomal membrane structures called endosome-to-TGN transport carriers (ETCs) which are budding from early endosome vacuoles just before maturing into late endosome vacuoles (PubMed:18088323). Colocalizes with DNAJC13 and Shiginella dysenteria toxin stxB on early endosomes (PubMed:19874558). Colocalized with F-actin at the leading edge of lamellipodia in a KALRN-dependent manner (PubMed:20604901). {ECO:0000269|PubMed:15498486, ECO:0000269|PubMed:18088323, ECO:0000269|PubMed:20604901}.
uniprot
proteins