RAB17
entrez
64284
canonical
uniprot
Q9H0T7
canonical
ensembl
ENSG00000124839
resolver
ensp
ENSP00000264601
resolver
ensp
ENSP00000608937
resolver
ensp
ENSP00000656971
resolver
ensp
ENSP00000684445
resolver
genesymbol
RAB17
resolver
hgnc
HGNC:16523
resolver
uniprot
Q53QV6
resolver
uniprot
Q6IA73
resolver
uniprot
Q6PJZ0
resolver
uniprot
Q9BVU1
resolver
uniprot
Q9H9U9
resolver
uniprot_entry
RAB17_HUMAN
resolver
uniprot_sec
Q53QV6
resolver
uniprot_sec
Q6IA73
resolver
uniprot_sec
Q6PJZ0
resolver
uniprot_sec
Q9BVU1
resolver
uniprot_sec
Q9H9U9
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MAQAHRTPQPRAAPSQPRVFKLVLLGSGSVGKSSLALRYVKNDFKSILPTVGCAFFTKVVDVGATSLKLEIWDTAGQEKYHSVCHLYFRGANAALLVYDITRKDSFLKAQQWLKDLEEELHPGEVLVMLVGNKTDLSQEREVTFQEGKEFADSQKLLFMETSAKLNHQVSEVFNTVAQELLQRSDEEGQALRGDAAVALNKGPARQAKCCAH
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB17 is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity). May also play a role in cell migration (PubMed:22328529). {ECO:0000250|UniProtKB:P20338, ECO:0000250|UniProtKB:P35292, ECO:0000269|PubMed:22328529}.
uniprot
proteins
mass_dalton
23491
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
21291502
uniprot
proteins
pubmed
22328529
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
212
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000250|UniProtKB:P35292}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Melanosome {ECO:0000250|UniProtKB:P35292}. Cell projection, dendrite {ECO:0000250|UniProtKB:P35292}. Note=May also localize at the basolateral and apical plasma membrane. In neurons, localizes to the cell body and dendritic shaft and spine. {ECO:0000250|UniProtKB:P35292}.
uniprot
proteins