Ptges
entrez
59103
canonical
uniprot
Q9JHF3
canonical
ensembl
ENSRNOG00000076770
resolver
ensembl
ENSRNOG00055007207
resolver
ensembl
ENSRNOG00065021085
resolver
ensp
ENSRNOP00000109200
resolver
ensp
ENSRNOP00055009461
resolver
ensp
ENSRNOP00065028911
resolver
enst
ENSRNOT00055011957
resolver
enst
ENSRNOT00065035852
resolver
genesymbol
Ptges
resolver
genesymbol_syn
Pges
resolver
genesymbol_syn
Pig12
resolver
uniprot_entry
PTGES_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activity is increased following LPS stimulation and down-regulated by the anti-inflammatory glucocorticoid dexamethasone. {ECO:0000269|PubMed:10869354}.
uniprot
proteins
amino_acid_sequence
MTSLGLVMENSQVLPAFLLCSTLLVIKMYAVAVITGQVRLRKKAFANPEDALKRGGLQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPLIAWIHFLVVLTGRVVHTVAYLGKMNPRIRSGAYVLAQFACFSMALQILWEVAHHL
uniprot
proteins
ec_number
1.11.1.-
uniprot
proteins
ec_number
2.5.1.18
uniprot
proteins
ec_number
5.3.99.3
uniprot
proteins
function
FUNCTION: Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (PubMed:10869354, PubMed:11067848). Similarly, catalyzes the conversion of PGH3 (derived from eicosapentaenoate (EPA, C20:5n-3)) to PGE3, though PGH2 remains the preferred substrate (By similarity). Plays a key role in inflammation response, fever and pain (By similarity). Also catalyzes the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2. In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (By similarity). {ECO:0000250|UniProtKB:O14684, ECO:0000250|UniProtKB:Q9JM51, ECO:0000269|PubMed:10869354, ECO:0000269|PubMed:11067848}.
uniprot
proteins
mass_dalton
17273
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; prostaglandin biosynthesis. {ECO:0000269|PubMed:10869354}.
uniprot
proteins
protein_family
MAPEG family
uniprot
proteins
pubmed
10754227
uniprot
proteins
pubmed
10869354
uniprot
proteins
pubmed
11067848
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
153
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:11067848}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O14684}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O14684}. Note=Colocalizes with PTGS1/COX-1 and PTGS2/COX-2 in the perinuclear compartment. {ECO:0000250|UniProtKB:O14684}.
uniprot
proteins
transmembrane_region
TRANSMEM 14..42; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O14684"; TRANSMEM 62..91; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O14684"; TRANSMEM 99..120; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O14684"; TRANSMEM 125..153; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O14684
uniprot
proteins