ATG9B
entrez
285973
canonical
uniprot
Q674R7
canonical
ensembl
ENSG00000181652
resolver
ensp
ENSP00000475737
resolver
ensp
ENSP00000491504
resolver
genesymbol
ATG9B
resolver
genesymbol_syn
APG9L2
resolver
genesymbol_syn
NOS3AS
resolver
hgnc
HGNC:21899
resolver
uniprot
A1A5D3
resolver
uniprot
Q6JRW5
resolver
uniprot
Q8N8I8
resolver
uniprot_entry
ATG9B_HUMAN
resolver
uniprot_sec
A1A5D3
resolver
uniprot_sec
Q6JRW5
resolver
uniprot_sec
Q8N8I8
resolver
amino_acid_sequence
MVSRMGWGGRRRRLGRWGDLGPGSVPLLPMPLPPPPPPSCRGPGGGRISIFSLSPAPHTRSSPSSFSPPTAGPPCSVLQGTGASQSCHSALPIPATPPTQAQPAMTPASASPSWGSHSTPPLAPATPTPSQQCPQDSPGLRVGPLIPEQDYERLEDCDPEGSQDSPIHGEEQQPLLHVPEGLRGSWHHIQNLDSFFTKIYSYHQRNGFACILLEDVFQLGQFIFIVTFTTFLLRCVDYNVLFANQPSNHTRPGPFHSKVTLSDAILPSAQCAERIRSSPLLVLLLVLAAGFWLVQLLRSVCNLFSYWDIQVFYREALHIPPEELSSVPWAEVQSRLLALQRSGGLCVQPRPLTELDIHHRILRYTNYQVALANKGLLPARCPLPWGGSAAFLSRGLALNVDLLLFRGPFSLFRGGWELPHAYKRSDQRGALAARWGRTVLLLAALNLALSPLVLAWQVLHVFYSHVELLRREPGALGARGWSRLARLQLRHFNELPHELRARLARAYRPAAAFLRTAAPPAPLRTLLARQLVFFAGALFAALLVLTVYDEDVLAVEHVLTAMTALGVTATVARSFIPEEQCQGRAPQLLLQTALAHMHYLPEEPGPGGRDRAYRQMAQLLQYRAVSLLEELLSPLLTPLFLLFWFRPRALEIIDFFHHFTVDVAGVGDICSFALMDVKRHGHPQWLSAGQTEASLSQRAEDGKTELSLMRFSLAHPLWRPPGHSSKFLGHLWGRVQQDAAAWGATSARGPSTPGVLSNCTSPLPEAFLANLFVHPLLPPRDLSPTAPCPAAATASLLASISRIAQDPSSVSPGGTGGQKLAQLPELASAEMSLHVIYLHQLHQQQQQQEPWGEAAASILSRPCSSPSQPPSPDEEKPSWSSDGSSPASSPRQQWGTQKARNLFPGGFQVTTDTQKEPDRASCTD
uniprot
proteins
function
FUNCTION: Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (By similarity). In addition to autophagy, also plays a role in necrotic cell death (By similarity). {ECO:0000250|UniProtKB:Q68FE2, ECO:0000250|UniProtKB:Q7Z3C6}.
uniprot
proteins
mass_dalton
101019
uniprot
proteins
protein_family
ATG9 family
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15234981
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15755735
uniprot
proteins
pubmed
17403686
uniprot
proteins
pubmed
18936157
uniprot
proteins
sequence_length
924
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Preautophagosomal structure membrane {ECO:0000269|PubMed:18936157}; Multi-pass membrane protein {ECO:0000269|PubMed:18936157}. Note=Under amino acid starvation or rapamycin treatment, redistributes from a juxtanuclear clustered pool to a dispersed peripheral cytosolic pool (PubMed:18936157). The starvation-induced redistribution depends on ULK1 and ATG13 (PubMed:18936157). {ECO:0000269|PubMed:18936157}.
uniprot
proteins
transmembrane_region
TRANSMEM 208..228; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 277..297; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 527..547; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 552..572; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins