HHLA2
entrez
11148
canonical
uniprot
Q9UM44
canonical
ensembl
ENSG00000114455
resolver
ensp
ENSP00000350402
resolver
ensp
ENSP00000417856
resolver
ensp
ENSP00000418284
resolver
ensp
ENSP00000418345
resolver
ensp
ENSP00000419207
resolver
ensp
ENSP00000566131
resolver
ensp
ENSP00000566133
resolver
ensp
ENSP00000566137
resolver
ensp
ENSP00000566146
resolver
enst
ENST00000491820
resolver
enst
ENST00000896087
resolver
genesymbol
HHLA2
resolver
hgnc
HGNC:4905
resolver
uniprot
B4DKN2
resolver
uniprot
C9J7D0
resolver
uniprot
D3DN60
resolver
uniprot
Q9NWQ6
resolver
uniprot_entry
C9J7D0_HUMAN
resolver
uniprot_entry
HHLA2_HUMAN
resolver
uniprot_sec
B4DKN2
resolver
uniprot_sec
D3DN60
resolver
uniprot_sec
Q9NWQ6
resolver
amino_acid_sequence
MKAQTALSFFLILITSLSGSQGIFPLAFFIYVPMNEQIVIGRLDEDIILPSSFERGSEVVIHWKYQDSYKVHSYYKGSDHLESQDPRYANRTSLFYNEIQNGNASLFFRRVSLLDEGIYTCYVGTAIQVITNKVVLKVGVFLTPVMKYEKRNTNSFLICSVLSVYPRPIITWKMDNTPISENNMEETGSLDSFSINSPLNITGSNSSYECTIENSLLKQTWTGRWTMKDGLHKMQSEHVSLSCQPVNDYFSPNQDFKVTWSRMKSGTFSVLAYYLSSSQNTIINESRFSWNKELINQSDFSMNLMDLNLSDSGEYLCNISSDEYTLLTIHTVHVEPSQETASHNKGLWILVPSAILAAFLLIWSVKCCRAQLEARRSRHPADGAQQERCCVPPGERCPSAPDNGEENVPLSGKV
uniprot
proteins
function
FUNCTION: Through interaction with TMIGD2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. {ECO:0000269|PubMed:23784006}.
uniprot
proteins
mass_dalton
46850
uniprot
proteins
pubmed
10444326
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
23784006
uniprot
proteins
sequence_length
414
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 345..365; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins