Setd3
entrez
52690
canonical
uniprot
Q91WC0
canonical
ensembl
ENSMUSG00000056770
resolver
ensp
ENSMUSP00000066413
resolver
ensp
ENSMUSP00000174697
resolver
ensp
ENSMUSP00000174700
resolver
ensp
ENSMUSP00000174742
resolver
genesymbol
Setd3
resolver
genesymbol_syn
D12Ertd771e
resolver
uniprot
Q6PEN3
resolver
uniprot
Q8CD86
resolver
uniprot
Q8CDX8
resolver
uniprot
Q9CZZ1
resolver
uniprot_entry
SETD3_MOUSE
resolver
uniprot_sec
Q6PEN3
resolver
uniprot_sec
Q8CD86
resolver
uniprot_sec
Q8CDX8
resolver
uniprot_sec
Q9CZZ1
resolver
amino_acid_sequence
MGKKSRVKTQKSGTGATATVSPKEILNLTSELLQKCSSPAPSPGKEWEEYTQIRALVEKIRKKQKGLSVTFDGKREDYFPDLMKWASENGASVEGFEMVNFKEEGFGLRATRDIKAEELFLWVPRKLLMTVESAKNSVLGPLYSQDRILQAMGNIALAFHLLCERASPNSFWQPYIQTLPSEYDTPLYFEEEEVRCLQSTQAIHDVFSQYKNTARQYAYFYKVIQTHPHANKLPLKESFTYEDYRWAVSSVMTRQNQIPTEDGSRVTLALIPLWDMCNHTNGLITTGYNLEDDRCECVALQDFQAGDQIYIFYGTRSNAEFVIHSGFFFDNNSHDRVKIKLGVSKSDRLYAMKAEVLARAGIPTSSVFALHSTEPPISAQLLAFLRVFCMTEEELKEHLLGDSAIDRIFTLGNAEFPVSWDNEVKLWTFLEDRASLLLKTYKTTIEEDKIVLKNPDLSVRATMAIKLRLGEKEILEKAVKSAAVNREYYRKHMEERAPLPRYEESDLGLLEGGVGDSRLPLVLRKLEEEAGVQESLSLTETVSKVKAAENGLVNGENLIPNGTRSENESLSPEESENVTGEESSGSMAKVKERL
uniprot
proteins
ec_number
2.1.1.85
uniprot
proteins
function
FUNCTION: Protein-histidine N-methyltransferase that specifically mediates 3-methylhistidine (tele-methylhistidine) methylation of actin at 'His-73' (PubMed:30626964). Histidine methylation of actin is required for smooth muscle contraction of the laboring uterus during delivery (PubMed:30626964). Does not have protein-lysine N-methyltransferase activity and probably only catalyzes histidine methylation of actin (PubMed:30626964). {ECO:0000269|PubMed:30626964}.
uniprot
proteins
mass_dalton
67176
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by GSK3B, which is required for recognition by the SCF(FBXW7) complex and subsequent degradation. {ECO:0000250|UniProtKB:Q86TU7}.; PTM: Ubiquitinated by the SCF(FBXW7) complex following phosphorylation by GSK3B, leading to its degradation by the proteasome. {ECO:0000250|UniProtKB:Q86TU7}.
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
SETD3 actin-histidine methyltransferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16008511
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21832073
uniprot
proteins
pubmed
30626964
uniprot
proteins
pubmed
30796205
uniprot
proteins
sequence_length
594
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q86TU7}. Nucleus {ECO:0000269|PubMed:21832073}. Note=Localizes mainly in the cytoplasm. {ECO:0000250|UniProtKB:Q86TU7}.
uniprot
proteins