NEK3
entrez
4752
canonical
uniprot
P51956
canonical
ensembl
ENSG00000136098
resolver
ensp
ENSP00000480328
resolver
ensp
ENSP00000484443
resolver
ensp
ENSP00000528846
resolver
ensp
ENSP00000583462
resolver
ensp
ENSP00000632708
resolver
genesymbol
NEK3
resolver
hgnc
HGNC:7746
resolver
uniprot
A8K2J4
resolver
uniprot
Q5TAP2
resolver
uniprot
Q6ZN64
resolver
uniprot
Q8J023
resolver
uniprot
Q8WUN5
resolver
uniprot_entry
NEK3_HUMAN
resolver
uniprot_entry
Q6ZN64_HUMAN
resolver
uniprot_sec
A8K2J4
resolver
uniprot_sec
Q5TAP2
resolver
uniprot_sec
Q8J023
resolver
uniprot_sec
Q8WUN5
resolver
activity_regulation
ACTIVITY REGULATION: Prolactin stimulates its activity. {ECO:0000269|PubMed:15618286}.
uniprot
proteins
amino_acid_sequence
MDDYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPKSFSNTQNSRKEAVLLAKMKHPNIVAFKESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKLFPEDMILNWFTQMCLGVNHIHKKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYNNKSDIWSLGCILYELCTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKRNPSHRPSATTLLSRGIVARLVQKCLPPEIIMEYGEEVLEEIKNSKHNTPRKKTNPSRIRIALGNEASTVQEEEQDRKGSHTDLESINENLVESALRRVNREEKGNKSVHLRKASSPNLHRRQWEKNVPNTALTALENASILTSSLTAEDDRGGSVIKYSKNTTRKQWLKETPDTLLNILKNADLSLAFQTYTIYRPGSEGFLKGPLSEETEASDSVDGGHDSVILDPERLEPGLDEEDTDFEEEDDNPDWVSELKKRAGWQGLCDR
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Protein kinase which influences neuronal morphogenesis and polarity through effects on microtubules. Regulates microtubule acetylation in neurons. Contributes to prolactin-mediated phosphorylation of PXN and VAV2. Implicated in prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells through mechanisms involving RAC1 activation and phosphorylation of PXN and VAV2. {ECO:0000269|PubMed:15618286, ECO:0000269|PubMed:17297458}.
uniprot
proteins
mass_dalton
57705
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-479 regulates its catalytic activity. {ECO:0000250}.
uniprot
proteins
protein_family
NEK Ser/Thr protein kinase family
uniprot
proteins
protein_family
NIMA subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
12063396
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15618286
uniprot
proteins
pubmed
17297458
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
7522034
uniprot
proteins
pubmed
8274451
uniprot
proteins
sequence_length
506
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell projection, axon {ECO:0000250}.
uniprot
proteins