Cdhr2
entrez
268663
canonical
uniprot
E9Q7P9
canonical
ensembl
ENSMUSG00000034918
resolver
ensp
ENSMUSP00000043596
resolver
enst
ENSMUST00000037145
resolver
genesymbol
Cdhr2
resolver
uniprot
B7ZP46
resolver
uniprot
B9EJ32
resolver
uniprot
Q3UN77
resolver
uniprot_entry
CDHR2_MOUSE
resolver
uniprot_sec
B7ZP46
resolver
uniprot_sec
B9EJ32
resolver
uniprot_sec
Q3UN77
resolver
amino_acid_sequence
MAWLWLLCALLPAFMVSVTANSPPSFGVNMTLVTLPEDLPVGAVAFWLVATDSDNDHLTYGISGPNASYFSVNANTGEVKLASPLDFETVPFFKITISTSDGLNIRTAEMQVIVEDRNDNIPVFLNTEFSTSINETLPVGSVVFSVLAEDKDTGTAGLVQYFIEKVIPSTANSNNLFRILENGSIVLNDTLSYNNKSAFYQLELKACDSGGILDNKPKTQCSQPVFVSISVIDEPDLDPRFIREFYSASVAEDATLGTSVLTVEAVDSDKGINDIVTYSVSNSTRPGWFDIREDGVIFVNGSLDREQLLLENEEVQIQVTATEKNLNIYGQEAKASMWVTIRVTDVNDHKPEFYNCSLPGCSFSPQEAQVNFIGYVDEHASARISIDGLTMVAYDPDQGDNGTFLLSLNGQDAEAFNVSPERAAGSVSVQVVVRNSEMVDYEKETVMVVEVVATDSVSNNYSVATVTIHLRNINDHRPVFSQSLYELTVPEHCPTGYLVTDKIQATDLDGDEWGPITYSLLPGNGADLFEVEPNSGNLTVKNGTLLDREKQAVYYLTLQATDGGNQSTTTALEITLLDINDNPPVVRGSYNVFVPEENGNVSVTIQAYDDDQPDTNNSLLVFSLLPGPYSSNFSLDPNTGLLRNLGPLDREAIDPALEGRIVLTVIVADCGEPSLSTNVNVTITVEDINDNLPVFNQSYEFSVWERVPGAWVGTVKAWDADQTAANNRISFSLSGTGANNFILQGNVLEQGWAEGSLWLLPDVRLDYETQKFFHLTVSAENPGPQGLDSTANVTVTVMDVNDEPPTLDAASLQAISVTENGSEHGQVTRVIAQDVDTAALLRIELVDVICTKAGVDVGSVCHGWFSVDGNGSVYINQSEAIDYEACHLVTLVVRAYDLNTDPGFDAYSSNGSLLINIKDKNDNAPYFLPNNQTFVIIPELVLPNQQVASVQARDEDSEDNGIIMFSILKAEFVRKDGTSNPVQVFRITRSVEAGLFTGSIELVTNLDSTIQGTYQVTVQAQDQPTLGPALETQTTLNLFTVDQSYRVRLQFSTSKEDVGANMEEIKEALIQATRTSVYVVTIQNIDSTARARASSYMDAYFVFSNGTALTLTELNMMIRKDQDALRQLLQLGLVVVSSQESQEPDQQKLLTSVIIGLVVSLVLVLVILITALVCLRKSYHRKLRAMKAGKEARKTPIETTAPTAAIPGTNMYNTDRANPVLDLPTKDLGLECHSSSDLDYDSLNSLDENSVDLDMDSKEFKRKDLPGDPPEPDPEPLTAVLSGRSAGASEQQKKNLSFTNPGLDTTDL
uniprot
proteins
function
FUNCTION: Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation. May also play a role in cell-cell adhesion and contact inhibition in epithelial cells. {ECO:0000250|UniProtKB:Q9BYE9}.
uniprot
proteins
mass_dalton
142633
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26812017
uniprot
proteins
sequence_length
1308
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q9BYE9}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9BYE9}. Cell projection, microvillus membrane {ECO:0000250|UniProtKB:Q9BYE9}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9BYE9}. Cell junction {ECO:0000250|UniProtKB:Q9BYE9}.
uniprot
proteins
transmembrane_region
TRANSMEM 1153..1173; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins