ECI2
entrez
10455
canonical
uniprot
O75521
canonical
ensembl
ENSG00000198721
resolver
ensp
ENSP00000354737
resolver
ensp
ENSP00000369461
resolver
ensp
ENSP00000369468
resolver
ensp
ENSP00000420309
resolver
enst
ENST00000361538
resolver
enst
ENST00000380125
resolver
enst
ENST00000465828
resolver
genesymbol
ECI2
resolver
genesymbol_syn
DRS1
resolver
genesymbol_syn
HCA88
resolver
genesymbol_syn
PECI
resolver
hgnc
HGNC:14601
resolver
uniprot
A0A0C4DGA2
resolver
uniprot
A0A140VK33
resolver
uniprot
Q5JYK5
resolver
uniprot
Q5JYK7
resolver
uniprot
Q7L124
resolver
uniprot
Q8N0X0
resolver
uniprot
Q9BUE9
resolver
uniprot
Q9H0T9
resolver
uniprot
Q9NQH1
resolver
uniprot
Q9NYH7
resolver
uniprot
Q9UN55
resolver
uniprot_entry
A0A0C4DGA2_HUMAN
resolver
uniprot_entry
A0A140VK33_HUMAN
resolver
uniprot_entry
ECI2_HUMAN
resolver
uniprot_sec
Q5JYK5
resolver
uniprot_sec
Q5JYK7
resolver
uniprot_sec
Q7L124
resolver
uniprot_sec
Q8N0X0
resolver
uniprot_sec
Q9BUE9
resolver
uniprot_sec
Q9H0T9
resolver
uniprot_sec
Q9NQH1
resolver
uniprot_sec
Q9NYH7
resolver
uniprot_sec
Q9UN55
resolver
amino_acid_sequence
MAMAYLAWRLARRSCPSSLQVTSFPVVQLHMNRTAMRASQKDFENSMNQVKLLKKDPGNEVKLKLYALYKQATEGPCNMPKPGVFDLINKAKWDAWNALGSLPKEAARQNYVDLVSSLSPSLESSSQVEPGTDRKSTGFETLVVTSEDGITKIMFNRPKKKNAINTEMYHEIMRALKAASKDDSIITVLTGNGDYYSSGNDLTNFTDIPPGGVEEKAKNNAVLLREFVGCFIDFPKPLIAVVNGPAVGISVTLLGLFDAVYASDRATFHTPFSHLGQSPEGCSSYTFPKIMSPAKATEMLIFGKKLTAGEACAQGLVTEVFPDSTFQKEVWTRLKAFAKLPPNALRISKEVIRKREREKLHAVNAEECNVLQGRWLSDECTNAVVNFLSRKSKL
uniprot
proteins
ec_number
5.3.3.8
uniprot
proteins
function
FUNCTION: Auxiliary enzyme in the beta-oxidation of mono- and polyunsaturated fatty acids (PubMed:10419495). Together with the 2,4-dienoyl-CoA reductase (DECR) and the Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase (ECH), they allow the reentrance of the enoyl-CoA into the beta-oxidation cycle (PubMed:10419495). Able to isomerize both 3-cis (3Z) and 3-trans (3E) double bonds into the 2-trans (2E) form in a range of fatty enoyl-CoA species, with a preference for (3E)-enoyl-CoAs over (3Z)-enoyl-CoAs (PubMed:10419495, PubMed:25515061). Based on its established catalytic mechanism, it is predicted to act also on other fatty acids besides those tested experimentally (Probable). {ECO:0000269|PubMed:10419495, ECO:0000269|PubMed:25515061, ECO:0000305|PubMed:10419495, ECO:0000305|PubMed:25515061}.
uniprot
proteins
mass_dalton
43585
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid beta-oxidation. {ECO:0000269|PubMed:10419495}.
uniprot
proteins
protein_family
Enoyl-CoA hydratase/isomerase family
uniprot
proteins
pubmed
10354522
uniprot
proteins
pubmed
10419495
uniprot
proteins
pubmed
10508479
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
11256614
uniprot
proteins
pubmed
12097419
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15217832
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25515061
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
394
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion {ECO:0000250|UniProtKB:Q5XIC0}.; SUBCELLULAR LOCATION: [Isoform 2]: Peroxisome matrix {ECO:0000269|PubMed:10419495}.
uniprot
proteins