Hbp1
entrez
27080
canonical
uniprot
Q62661
canonical
ensembl
ENSRNOG00000008927
resolver
ensp
ENSRNOP00000012004
resolver
enst
ENSRNOT00000012004
resolver
genesymbol
Hbp1
resolver
uniprot
Q5BK86
resolver
uniprot
Z4YNI2
resolver
uniprot_entry
HBP1_RAT
resolver
uniprot_entry
Z4YNI2_RAT
resolver
uniprot_sec
Q5BK86
resolver
amino_acid_sequence
MVWEVKTNQRPHAVQRLLLVMDERATGVSDSLELLQCNENVPSSPGYNSCDEHMELDDLPELQAVQSDPTQSAIYQLSSDVSHQEYPRPSWSQNTSDIPENTHREDEVDWLTELANIATSPQSPLMQCSFYNRSSPVHIIATSKSLHSYARPPPVSSAKSGPAFPHDHWKEETPVRHERANSESESGIFCMSSLSDDDDLGWCNSWPSTVWHCFLKGTRLCFHKESKKEWQDVEDFARAASCDEEEIQMGTHKGYGSDGLKLLSHEESVSFGESVLKLTFDPGTVEDGLLTVECKLDHPFYVKNKGWSSFYPSLTVVQHGIPCCEIHIGDVCLPPGHPDAINFDDSGVFDTFKSYDFTPMDSSAVYVLSSMARQRRASLSCGGPGTGQEFAGSEFSKSCGSPGSSQLSSSSLYTKAVKSHSSGTVSATSPNKCKRPMNAFMLFAKKYRVEYTQMYPGKDNRAISVILGDRWKKMKNEERRMYTLEAKALAEEQKRLNPDCWKRKRTNSGSQQH
uniprot
proteins
function
FUNCTION: Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4 (By similarity). {ECO:0000250|UniProtKB:O60381}.
uniprot
proteins
mass_dalton
57430
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the CTLH E3 ubiquitin-protein ligase complex, leading to subsequent proteasomal degradation. {ECO:0000250|UniProtKB:O60381}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7937077
uniprot
proteins
pubmed
9178770
uniprot
proteins
sequence_length
513
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
uniprot
proteins