Limk2
entrez
16886
canonical
uniprot
O54785
canonical
ensembl
ENSMUSG00000020451
resolver
ensp
ENSMUSP00000099162
resolver
ensp
ENSMUSP00000099163
resolver
ensp
ENSMUSP00000099165
resolver
ensp
ENSMUSP00000105656
resolver
ensp
ENSMUSP00000276715
resolver
enst
ENSMUST00000101640
resolver
genesymbol
Limk2
resolver
uniprot
O54776
resolver
uniprot
O55238
resolver
uniprot
Q5NC03
resolver
uniprot
Q8BS94
resolver
uniprot
Q9QUL4
resolver
uniprot_entry
LIMK2_MOUSE
resolver
uniprot_entry
Q5NC03_MOUSE
resolver
uniprot_entry
Q8BS94_MOUSE
resolver
uniprot_sec
O54776
resolver
uniprot_sec
O55238
resolver
uniprot_sec
Q9QUL4
resolver
amino_acid_sequence
MAALAGDEAWRCRGCGTYVPLSQRLYRTANEAWHGSCFRCSECQESLTNWYYEKDGKLYCHKDYWAKFGEFCHGCSLLMTGPAMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQDQLPYSVTLISMPATTECRRGFSVTVESASSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAIKQTSQTLQLLIEHDPVPQRLDQLRLDARLPPHMQSTGHTLMLSTLDTKENQEGTLRRRSLRRSNSISKSPGPSSPKEPLLLSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSVDPFPWQQKVRFAKGISSGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEERKRPPVEKATTKKRTLRKSDRKKRYTVVGNPYWMAPEMLNGKSYDETVDVFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCKLEPESRPAFSKLEDSFEALSLFLGELAIPLPAELEDLDHTVSMEYGLTRDSPP
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP. Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (By similarity). {ECO:0000250|UniProtKB:P53671}.
uniprot
proteins
mass_dalton
72202
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine and/or threonine residues by ROCK1. {ECO:0000250|UniProtKB:P53671}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
TKL Ser/Thr protein kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18332102
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9425257
uniprot
proteins
pubmed
9441759
uniprot
proteins
pubmed
9610354
uniprot
proteins
pubmed
9705845
uniprot
proteins
sequence_length
638
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:P53671}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P53671}.; SUBCELLULAR LOCATION: [Isoform LIMK2a]: Cytoplasm {ECO:0000250|UniProtKB:P53671}. Nucleus {ECO:0000250|UniProtKB:P53671}.; SUBCELLULAR LOCATION: [Isoform LIMK2b]: Cytoplasm {ECO:0000250|UniProtKB:P53671}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P53671}. Nucleus {ECO:0000250|UniProtKB:P53671}.
uniprot
proteins