Csk
entrez
12988
canonical
uniprot
P41241
canonical
ensembl
ENSMUSG00000032312
resolver
ensp
ENSMUSP00000034863
resolver
ensp
ENSMUSP00000150590
resolver
ensp
ENSMUSP00000150984
resolver
ensp
ENSMUSP00000301735
resolver
ensp
ENSMUSP00000301737
resolver
ensp
ENSMUSP00000301742
resolver
ensp
ENSMUSP00000301743
resolver
ensp
ENSMUSP00000336410
resolver
enst
ENSMUST00000034863
resolver
enst
ENSMUST00000215396
resolver
enst
ENSMUST00000217314
resolver
genesymbol
Csk
resolver
uniprot
Q03143
resolver
uniprot
Q80WU4
resolver
uniprot
Q8VCW1
resolver
uniprot_entry
CSK_MOUSE
resolver
uniprot_sec
Q03143
resolver
uniprot_sec
Q80WU4
resolver
uniprot_sec
Q8VCW1
resolver
amino_acid_sequence
MSAIQAAWPSGTECIAKYNFHGTAEQDLPFCKGDVLTIVAVTKDPNWYKAKNKVGREGIIPANYVQKREGVKAGTKLSLMPWFHGKITREQAERLLYPPETGLFLVRESTNYPGDYTLCVSCEGKVEHYRIMYHASKLSIDEEVYFENLMQLVEHYTTDADGLCTRLIKPKVMEGTVAAQDEFYRSGWALNMKELKLLQTIGKGEFGDVMLGDYRGNKVAVKCIKNDATAQAFLAEASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLRSRGRSVLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQDTGKLPVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPPAVYEVMKNCWHLDAATRPTFLQLREQLEHIKTHELHL
uniprot
proteins
ec_number
2.7.10.4
uniprot
proteins
function
FUNCTION: Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK, SRC, HCK, FYN, LYN, CSK or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK (By similarity). May act as a negative regulator of EGFR and STAT3 signaling pathways (By similarity). {ECO:0000250|UniProtKB:P41240}.
uniprot
proteins
mass_dalton
50716
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-364 by PKA, leading to increased activity. Autophosphorylated (By similarity). {ECO:0000250|UniProtKB:P41240}.
uniprot
proteins
protein_family
CSK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
11685249
uniprot
proteins
pubmed
12218089
uniprot
proteins
pubmed
12612075
uniprot
proteins
pubmed
1281307
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16166631
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23526378
uniprot
proteins
pubmed
28290451
uniprot
proteins
pubmed
7511815
uniprot
proteins
pubmed
7685657
uniprot
proteins
pubmed
8890164
uniprot
proteins
pubmed
9858471
uniprot
proteins
sequence_length
450
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16166631}. Cell membrane {ECO:0000269|PubMed:16166631}. Note=Mainly cytoplasmic, also present in lipid rafts.
uniprot
proteins