Lmbrd1
entrez
246046
canonical
uniprot
Q6AZ61
canonical
ensembl
ENSRNOG00000012178
resolver
ensembl
ENSRNOG00055001594
resolver
ensembl
ENSRNOG00060015362
resolver
ensembl
ENSRNOG00065018861
resolver
ensp
ENSRNOP00000106228
resolver
ensp
ENSRNOP00055001927
resolver
ensp
ENSRNOP00060021055
resolver
ensp
ENSRNOP00065025256
resolver
enst
ENSRNOT00000133337
resolver
enst
ENSRNOT00055002554
resolver
enst
ENSRNOT00060026321
resolver
enst
ENSRNOT00065031680
resolver
genesymbol
Lmbrd1
resolver
uniprot
Q8R3Z8
resolver
uniprot_entry
LMBD1_RAT
resolver
uniprot_sec
Q8R3Z8
resolver
amino_acid_sequence
MAAAAADLVIGWCIFGLLLLAILAFCWVYVRKYQSQRESEVVSTVTAIFSLAVALITSALLPVDIFLVSYMKNQNGTFKDWANANVTVQIENTVLYGYYTLYSVILFCVFFWIPFVYFYYEEKDDDDTSKCTQVKTALKYTLGFVVICALLLLVGAFVPLNLPNNNNSTEWEKVKLLFEDLGTGQGLAALSFSISSLTLIGMLAAITYTAYGMSALPLNLIKGTRSTAYERLENTEDIEEVEQHIQTIRSKSKDGRPLSARDRRTLKQCEERLRTLRKRERHLEFIENSWWTKFCGALRPLKIIWGIFFILVALLFVISLFLSNLDKALHSAGIDSGFIVFGTNLSNPLNMLLPLLQTVFPLDYILITIIIMYFIFTSMAGIRNIGIWFFWIRLYKIRRGRTRPQALLFLCMILLLIVLHTSYMIYSLAPQYVMYGSQNYLIESNITSDAHKGNSTLAVPKRCDADAPKDQCTVTRTYVFLHKFWFFSAAYYFGNWAFLVVFLIGLIVSCCKGKKSVIEGVDEDSDLSDDEPSAYSA
uniprot
proteins
function
FUNCTION: Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors. Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome. Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane (By similarity). Acts as an adapter protein which plays an important role in mediating and regulating the internalization of the insulin receptor (INSR) (By similarity). Involved in clathrin-mediated endocytosis of INSR via its interaction with adapter protein complex 2 (By similarity). Essential for the initiation of gastrulation and early formation of mesoderm structures during embryogenesis (By similarity). {ECO:0000250|UniProtKB:Q8K0B2, ECO:0000250|UniProtKB:Q9NUN5}.
uniprot
proteins
mass_dalton
61018
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q9NUN5}.
uniprot
proteins
protein_family
LIMR family
uniprot
proteins
protein_family
LMBRD1 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
537
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9NUN5}. Lysosome membrane {ECO:0000250|UniProtKB:Q9NUN5}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q8K0B2}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q8K0B2}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 48..68; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 98..118; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 142..162; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 186..206; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 303..323; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 362..382; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 406..426; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 484..504; /note="Helical; Name=9"; /evidence="ECO:0000255
uniprot
proteins