Tyms
entrez
22171
canonical
uniprot
P07607
canonical
ensembl
ENSMUSG00000025747
resolver
ensp
ENSMUSP00000026846
resolver
enst
ENSMUST00000026846
resolver
genesymbol
Tyms
resolver
uniprot
Q544L2
resolver
uniprot_entry
Q544L2_MOUSE
resolver
uniprot_entry
TYSY_MOUSE
resolver
amino_acid_sequence
MLVVGSELQSDAQQLSAEAPRHGELQYLRQVEHILRCGFKKEDRTGTGTLSVFGMQARYSLRDEFPLLTTKRVFWKGVLEELLWFIKGSTNAKELSSKGVRIWDANGSRDFLDSLGFSARQEGDLGPVYGFQWRHFGAEYKDMDSDYSGQGVDQLQKVIDTIKTNPDDRRIIMCAWNPKDLPLMALPPCHALCQFYVVNGELSCQLYQRSGDMGLGVPFNIASYALLTYMIAHITGLQPGDFVHTLGDAHIYLNHIEPLKIQLQREPRPFPKLKILRKVETIDDFKVEDFQIEGYNPHPTIKMEMAV
uniprot
proteins
ec_number
2.1.1.45
uniprot
proteins
function
FUNCTION: Catalyzes the reductive methylation of 2'-deoxyuridine 5'-monophosphate (dUMP) to thymidine 5'-monophosphate (dTMP), using the cosubstrate, 5,10- methylenetetrahydrofolate (CH2H4folate) as a 1-carbon donor and reductant and contributes to the mitochondrial and nuclear de novo thymidylate biosynthesis pathway. {ECO:0000250|UniProtKB:P04818}.
uniprot
proteins
mass_dalton
34958
uniprot
proteins
pathway_participation
PATHWAY: Pyrimidine metabolism; dTTP biosynthesis. {ECO:0000250|UniProtKB:P45352}.
uniprot
proteins
post_translational_modification
PTM: Sumoylated by UBE2I/UBC9. {ECO:0000250|UniProtKB:P04818}.
uniprot
proteins
protein_family
Thymidylate synthase family
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2915925
uniprot
proteins
pubmed
3444407
uniprot
proteins
pubmed
3782103
uniprot
proteins
sequence_length
307
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P04818}. Cytoplasm {ECO:0000250|UniProtKB:P04818}. Mitochondrion {ECO:0000250|UniProtKB:P04818}. Mitochondrion matrix {ECO:0000250|UniProtKB:P04818}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:P04818}. Note=Localized to the nucleus during S and G2/M phasesof the cell cycle. As a component of the de novo thymidylate synthesis complex, localizes specifically to replication forks during DNA synthesis (By similarity). {ECO:0000250|UniProtKB:P04818}.
uniprot
proteins