Akap13
entrez
75547
canonical
uniprot
E9Q394
canonical
ensembl
ENSMUSG00000066406
resolver
ensp
ENSMUSP00000129784
resolver
ensp
ENSMUSP00000147237
resolver
enst
ENSMUST00000207750
resolver
genesymbol
Akap13
resolver
genesymbol_syn
Brx
resolver
uniprot
A0A140LJJ5
resolver
uniprot
Q3UEI5
resolver
uniprot_entry
A0A140LJJ5_MOUSE
resolver
uniprot_entry
AKP13_MOUSE
resolver
uniprot_sec
Q3UEI5
resolver
amino_acid_sequence
MKLSPQQAPLYGDCVVTVLLAEEDKVEDDAIFYLIFSGSTLYHCTSTRKVSSDTLETIAPGHDCCETVKVLLCASREGLPVFVVAEEDFHFVQDEAYDAAQFLATSAGNQQALNFTRFLDRSGPPSRDVNSLDEKVALAFRHLKLPAEWNVLGTDHTLHDGGPRETLMHFAVRLGLLRLTWFLLQKPGGRGALSIHNKEGATPVSLALERGYHELHQLLTEENAGEPDSWSSLSYEIPYGDCSVRHHRELDIYTLTSESESHREPHGDSCTGHISKLMNIQQQLMKTNLKQMDNLMPLMVTAQDSSCVPSVPETDGLFLPCVPEPSDHQHPPFEETKSTLCCQRSPGRMAESSCDLSSMVEEENVICSHKKNKDVGRKGEEAEPASAMDSGSASHQDSCLQSVPDCGVKGREGLPSCGNRNEVTGTNYSGVATCQQPLSSRSSVLQDAMVTEPDACQHSSGRELPDSSSTDVGAPEKAGELEHSLLTPDATTQNNKPQVGEGTKERLENSDSSTTETTAVQVLSEPMEKADITNHVFATSAVGVNTPAEASPALSSEEIPTEKPGMETQERGCEGGTTSDQSSPVLPAAAIENKVLGGQEPDTSIAGFCKTASPLDLTMPGPSSDGMPEQNSESHARPAQSLSGQALLCSTAEAGTPSAEATHQPSTVTSSGRLEECGSGKASLPESTMVQPSTQELCTTLCPEDPQADTVTSDTVKNTQKSVGVCHLCVSDAKNQGNGLKQDTPLTNVLEDVPRLPSVVSQTEKELAPDQVSPPASSFSLASSPESESVTKDDALSLVPSQKEKGTATPQLHRTTACRDGPDGRDLSDTDKVGDGATDPPPSSAVELRTSMGNTSPVGIGGEQEGSSPTATLEVLSDSLLHNVDKAALVSDFTLPEEGVSVVVPESSTALGQDGKDRAMSCSSVKEDVHSSEMSREDQRTPPSGQEIPGLCEKPMSALCAEEKAQQHTPSACLKTETKDIKEVAPQVSLLTEGGAAKSLVPPRTSLSADSKQKASSTEQSGSSLLPSGLPGASEALHCNQPSALDVVVENTQFQGETNACEVSRSAMEDVTVADASPATAEPRKKDASHCIKDIPISELLNQEKQMTPSLPEAFLDKGVTDLQEVITPEIEPLDCKRETLEGTDLNCATSNSKETPIEKPMQPLARDLPTETGLSVINNNVPQADMKQVAQASIPAEESNATTVSTQAADVPTRADSIEETATRIVEAVIRQVRASNALMAKVETQNPSLSSPETKQLENAYTESACAFLPGETPQIEKTHEDTTGQCGAETEEPEKIILPESAPGKQGKMPDTRTGDEVDLLSRISAASEEEAVGNGAATPKMKQGPGTQAINRESWCAIEPCPEAASLLASKQSSECRSFIDVGLGTECASKEGMLQRVSGSESDLFHSPSDEMDSIIFPKPEEEQLLCDTTGSSSSTDDTASLDRHSSHGSDVSLPQTSKLNRSRNHQSANGFFSPGVEAPESRESESEPAGSGEMEEEEMDSITEVPANCSFLRSSMRSLSPFRRHSWGPGKNAASDAEMNQRSSMRALGHVVRRPPIHRRSFSLEGLTGGGVGNKPSSSLEMSSANSSELRNPFGGEEQRNSLMSLSEEHLEPDQRQHHRMFDQQTCYRSKQQGFNYCTSAISSPLTKSISLMTISHPGLDSSRPFHSTSANLTESITEENCNFLPPSPSKKNFEEKSGTKVSRTFSYIRNKMSSSKKSKEKEKEKDKIKEKEKDSKEKEKDKKTLNGHTFSPIPIVGPISCSQCMKPFTNKDAYTCAGCGAFVHKGCRENLASCAKVKMKQPKGSLQAHDTSSLPTVIMRNKSSQPKERPRSAVLLADEATAAPMFTNRRSQQSVSLSKSVSIQNITGVGNDENMSNTWKFLSHSTDSLNKICKVNESTESLTDEGVGTDMNEGQLMGDFESDSKQLEAESWSRTVDSKFLKQQKKDVVKRQEVIYELMQTELHHIRTLKIMSDVYSRGMMTDLLFEQQMVEKLFPCLDELISIHSQFFQRILERKKESLVDKSEKNFLIKRIGDVLVSQFSGESAERLKKTYGKFCGQHNQSVNYFKDLYTKDKRFQAFVKKKMSSSVVRRLGIPECILLVTQRITKYPVLFQRILQCTKDNEVEQEDLTQSLSLVKDVIGAVDSKVASYEKKVRLGEIYTKTDSKSIMRMKSGQMFAKEDLRRKKLVRDGSVFLKSTTGRLKEVQAVLLTDILVFLQEKDQKYVFASLDHKSTVISLKKLIVREVAHEEKGLFLISMGVKDPEMVEVHASSREERNSWIQIIQDTINSLNRDEDEGIPSENEEEKKLLDTKARELKEQLQQKDQQILLLLEEKEMIFRDMTECSTPLPEDCSPTHSPRVLFRSNTEEALKGGPLMKSAINEVEILQSLVSGSLGGTLGQSISSPVEQEVMAAPISLPRRAETFGGFDCHQMNASKGGEKEEGDDGQDLRRTESDSGLKKGGNGNLVFMLKRNSEQVVQSIVHLHELLSMLQGVVLQQDSYIEDQKLVLTEKVLTRSASRPSSLIEQEKQRSLEKQRQDLANLQKQQAQHLEEKRRREREWEAREQELRDREAKLAEREETVRRRQQDLERDREELQQKKGTYQCDLERLRAAQKQLEREQEQLRRDTERLSQRQMDQNLCQVSNKHGRLMRIPSFLPNSDEFSSPSAPSVTKSGSLDSELSVSPKRNSISRTQKDKGPFHILGSASQTKVPEGQSQAPSSTSTSTRLFGLSKPKEKKEKKKKSKGSRTQPGDGPASEVPAEGEEIFC
uniprot
proteins
function
FUNCTION: Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor. May also activate other Rho family members (By similarity). Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14. Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity. Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G protein-coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1 (By similarity). Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA) (By similarity). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2. Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3 (By similarity). Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy (PubMed:24161911). Has no guanine nucleotide exchange activity on CDC42, Ras or Rac (By similarity). Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes (PubMed:20139090). Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol (PubMed:24161911). Required for normal adaptive cardiac hypertrophy in response to pressure overload (PubMed:17537920, PubMed:24161911). Plays a role in osteogenesis (PubMed:25892096). {ECO:0000250|UniProtKB:Q12802, ECO:0000269|PubMed:17537920, ECO:0000269|PubMed:20139090, ECO:0000269|PubMed:24161911, ECO:0000269|PubMed:25892096}.
uniprot
proteins
mass_dalton
303976
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16469733
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17537920
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20139090
uniprot
proteins
pubmed
21102438
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23090968
uniprot
proteins
pubmed
23658642
uniprot
proteins
pubmed
24161911
uniprot
proteins
pubmed
25892096
uniprot
proteins
pubmed
38085732
uniprot
proteins
sequence_length
2776
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q12802}. Cytoplasm {ECO:0000250|UniProtKB:Q12802}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q12802}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:20139090}. Nucleus {ECO:0000250|UniProtKB:Q12802}. Membrane {ECO:0000250|UniProtKB:Q12802}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q12802}. Note=Colocalizes with actin and myosin filaments in developing cardiomyocytes (PubMed:20139090). Colocalizes with the actin cytoskeleton at the cell cortex (By similarity). {ECO:0000250|UniProtKB:Q12802, ECO:0000269|PubMed:20139090}.
uniprot
proteins