CYP2C8
entrez
1558
canonical
uniprot
P10632
canonical
ensembl
ENSG00000138115
resolver
ensp
ENSP00000360317
resolver
ensp
ENSP00000445062
resolver
ensp
ENSP00000485110
resolver
enst
ENST00000623108
resolver
genesymbol
CYP2C8
resolver
hgnc
HGNC:2622
resolver
uniprot
A0A096LNM3
resolver
uniprot
A8K9N8
resolver
uniprot
B0AZN2
resolver
uniprot
B7Z1F5
resolver
uniprot
B7Z1F6
resolver
uniprot
F5H7Q9
resolver
uniprot
Q5VX93
resolver
uniprot
Q8WWB1
resolver
uniprot
Q9UCZ9
resolver
uniprot_entry
A0A096LNM3_HUMAN
resolver
uniprot_entry
B7Z1F5_HUMAN
resolver
uniprot_entry
CP2C8_HUMAN
resolver
uniprot_sec
A8K9N8
resolver
uniprot_sec
B0AZN2
resolver
uniprot_sec
B7Z1F6
resolver
uniprot_sec
F5H7Q9
resolver
uniprot_sec
Q5VX93
resolver
uniprot_sec
Q8WWB1
resolver
uniprot_sec
Q9UCZ9
resolver
amino_acid_sequence
MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV
uniprot
proteins
ec_number
1.14.14.1
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:11093772, PubMed:14559847, PubMed:15766564, PubMed:19965576, PubMed:7574697). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:11093772, PubMed:14559847, PubMed:15766564, PubMed:19965576, PubMed:7574697). Primarily catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) with a preference for the last double bond (PubMed:15766564, PubMed:19965576, PubMed:7574697). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes all trans-retinoic acid toward its 4-hydroxylated form (PubMed:11093772). Displays 16-alpha hydroxylase activity toward estrogen steroid hormones, 17beta-estradiol (E2) and estrone (E1) (PubMed:14559847). Plays a role in the oxidative metabolism of xenobiotics. It is the principal enzyme responsible for the metabolism of the anti-cancer drug paclitaxel (taxol) (PubMed:26427316). {ECO:0000269|PubMed:11093772, ECO:0000269|PubMed:14559847, ECO:0000269|PubMed:15766564, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:26427316, ECO:0000269|PubMed:7574697}.
uniprot
proteins
mass_dalton
55825
uniprot
proteins
pathway_participation
PATHWAY: Steroid metabolism. {ECO:0000269|PubMed:14559847}.; PATHWAY: Lipid metabolism; arachidonate metabolism. {ECO:0000269|PubMed:15766564, ECO:0000269|PubMed:19965576, ECO:0000269|PubMed:7574697}.; PATHWAY: Cofactor metabolism; retinol metabolism. {ECO:0000269|PubMed:11093772}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
11093772
uniprot
proteins
pubmed
11668219
uniprot
proteins
pubmed
12429347
uniprot
proteins
pubmed
14559847
uniprot
proteins
pubmed
14676196
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15365880
uniprot
proteins
pubmed
15469410
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15766564
uniprot
proteins
pubmed
1707679
uniprot
proteins
pubmed
18413310
uniprot
proteins
pubmed
19965576
uniprot
proteins
pubmed
2009263
uniprot
proteins
pubmed
2216732
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26427316
uniprot
proteins
pubmed
2729895
uniprot
proteins
pubmed
3196692
uniprot
proteins
pubmed
3500169
uniprot
proteins
pubmed
3697070
uniprot
proteins
pubmed
7574697
uniprot
proteins
sequence_length
490
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
uniprot
proteins