OPN1MW3
entrez
101060233
canonical
uniprot
P0DN78
canonical
ensembl
ENSG00000166160
resolver
ensembl
ENSG00000268221
resolver
ensembl
ENSG00000269433
resolver
ensp
ENSP00000358945
resolver
ensp
ENSP00000469970
resolver
ensp
ENSP00000472316
resolver
enst
ENST00000369929
resolver
enst
ENST00000595290
resolver
enst
ENST00000599405
resolver
genesymbol
OPN1MW3
resolver
hgnc
HGNC:51831
resolver
uniprot_entry
OPSG3_HUMAN
resolver
amino_acid_sequence
MAQQWSLQRLAGRHPQDSYEDSTQSSIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSVWMIFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISVVNQVYGYFVLGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNVRFDAKLAIVGIAFSWIWAAVWTAPPIFGWSRYWPHGLKTSCGPDVFSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMVLAFCFCWGPYAFFACFAAANPGYPFHPLMAALPAFFAKSATIYNPVIYVFMNRQFRNCILQLFGKKVDDGSELSSASKTEVSSVSSVSPA
uniprot
proteins
function
FUNCTION: G protein-coupled photoreceptor that selectively activates transducin G alpha protein (G(t)) in response to medium-wavelength (green) light, thereby stimulating the G(t)/transducin protein pathway (By similarity). This activation leads to increased cGMP phosphodiesterase activity, resulting in decreased intracellular cGMP and subsequent closure of cGMP-gated ion channels. The process is initiated when the opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers the G protein-mediated phototransduction cascade (By similarity). Mediates visual perception of green light in cone photoreceptor cells (By similarity). {ECO:0000250|UniProtKB:P04000, ECO:0000250|UniProtKB:P04001}.
uniprot
proteins
mass_dalton
40584
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. O-glycosylated. {ECO:0000250|UniProtKB:P04001}.; PTM: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region. {ECO:0000250|UniProtKB:P04001}.; PTM: Contains one retinal chromophore covalently bound to a lysine residue via a Schiff base. Upon light absorption, the bound 11-cis-retinal isomerizes to all-trans-retinal. Following activation, the covalently bound all-trans-retinal is released through hydrolysis of the Schiff base, and OPN1 is regenerated by binding a new 11-cis-retinal molecule. {ECO:0000250|UniProtKB:P04001}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Opsin subfamily
uniprot
proteins
pubmed
15772651
uniprot
proteins
sequence_length
364
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P04001}; Multi-pass membrane protein {ECO:0000255}. Photoreceptor outer segment membrane {ECO:0000250|UniProtKB:O35599}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 53..77; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 90..115; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 130..149; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 169..192; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 219..246; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 269..292; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 301..325; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins