Bcl2l1
entrez
12048
canonical
uniprot
Q64373
canonical
ensembl
ENSMUSG00000007659
resolver
ensp
ENSMUSP00000007803
resolver
ensp
ENSMUSP00000105445
resolver
ensp
ENSMUSP00000265842
resolver
ensp
ENSMUSP00000265843
resolver
ensp
ENSMUSP00000265854
resolver
ensp
ENSMUSP00000265855
resolver
ensp
ENSMUSP00000265856
resolver
genesymbol
Bcl2l1
resolver
genesymbol_syn
Bcl2l
resolver
genesymbol_syn
Bclx
resolver
uniprot
O35843
resolver
uniprot
O35844
resolver
uniprot
Q5HZH3
resolver
uniprot
Q60657
resolver
uniprot
Q60658
resolver
uniprot
Q61338
resolver
uniprot_entry
B2CL1_MOUSE
resolver
uniprot_entry
O35843_MOUSE
resolver
uniprot_entry
Q5HZH3_MOUSE
resolver
uniprot_sec
O35844
resolver
uniprot_sec
Q60657
resolver
uniprot_sec
Q60658
resolver
uniprot_sec
Q61338
resolver
amino_acid_sequence
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEETEAERETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIASWMATYLNDHLEPWIQENGGWDTFVDLYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
uniprot
proteins
function
FUNCTION: Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. {ECO:0000269|PubMed:9390687}.; FUNCTION: Isoform Bcl-X(L) also regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availability from mitochondria through regulation of mitochondrial membrane ATP synthase F(1)F(0) activity and regulates endocytic vesicle retrieval in hippocampal neurons through association with DMN1L and stimulation of its GTPase activity in synaptic vesicles (By similarity). May attenuate inflammation impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q07817}.; FUNCTION: Isoform Bcl-X(S) promotes apoptosis. {ECO:0000250}.
uniprot
proteins
mass_dalton
26132
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity. {ECO:0000250}.; PTM: Phosphorylated on Ser-62 by CDK1. This phosphorylation is partial in normal mitotic cells, but complete in G2-arrested cells upon DNA-damage, thus promoting subsequent apoptosis probably by triggering caspases-mediated proteolysis. Phosphorylated by PLK3, leading to regulate the G2 checkpoint and progression to cytokinesis during mitosis. Phosphorylation at Ser-49 appears during the S phase and G2, disappears rapidly in early mitosis during prometaphase, metaphase and early anaphase, and re-appears during telophase and cytokinesis (By similarity). {ECO:0000250}.; PTM: Ubiquitinated by RNF183 during prolonged ER stress, leading to degradation by the proteosome. {ECO:0000250|UniProtKB:Q07817}.
uniprot
proteins
protein_family
Bcl-2 family
uniprot
proteins
pubmed
14499110
uniprot
proteins
pubmed
16509771
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21502331
uniprot
proteins
pubmed
27013495
uniprot
proteins
pubmed
7607090
uniprot
proteins
pubmed
7963517
uniprot
proteins
pubmed
9144489
uniprot
proteins
pubmed
9390687
uniprot
proteins
sequence_length
233
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000269|PubMed:7607090}; Single-pass membrane protein {ECO:0000269|PubMed:7607090}. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:7607090}. Note=Localizes to the centrosome when phosphorylated at Ser-49.; SUBCELLULAR LOCATION: [Isoform Bcl-X(L)]: Mitochondrion inner membrane. Mitochondrion outer membrane. Mitochondrion matrix {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner. {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform Bcl-X(delta-TM)]: Cytoplasm.
uniprot
proteins
transmembrane_region
TRANSMEM 210..226; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins