IER3
entrez
8870
canonical
uniprot
P46695
canonical
ensembl
ENSG00000137331
resolver
ensembl
ENSG00000206478
resolver
ensembl
ENSG00000227231
resolver
ensembl
ENSG00000230128
resolver
ensembl
ENSG00000235030
resolver
ensembl
ENSG00000237155
resolver
ensp
ENSP00000259874
resolver
ensp
ENSP00000373054
resolver
ensp
ENSP00000397956
resolver
ensp
ENSP00000398139
resolver
ensp
ENSP00000406245
resolver
ensp
ENSP00000412283
resolver
enst
ENST00000259874
resolver
enst
ENST00000383560
resolver
enst
ENST00000416884
resolver
enst
ENST00000435856
resolver
enst
ENST00000439190
resolver
enst
ENST00000450236
resolver
genesymbol
IER3
resolver
genesymbol_syn
DIF2
resolver
genesymbol_syn
IEX1
resolver
genesymbol_syn
PRG1
resolver
hgnc
HGNC:5392
resolver
uniprot
Q5SU30
resolver
uniprot
Q92691
resolver
uniprot
Q93044
resolver
uniprot_entry
IEX1_HUMAN
resolver
uniprot_sec
Q5SU30
resolver
uniprot_sec
Q92691
resolver
uniprot_sec
Q93044
resolver
amino_acid_sequence
MCHSRSCHPTMTILQAPTPAPSTIPGPRRGSGPEIFTFDPLPEPAAAPAGRPSASRGHRKRSRRVLYPRVVRRQLPVEEPNPAKRLLFLLLTIVFCQILMAEEGVPAPLPPEDAPNAASLAPTPVSAVLEPFNLTSEPSDYALDLSTFLQQHPAAF
uniprot
proteins
function
FUNCTION: May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Also acts as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. {ECO:0000269|PubMed:12356731, ECO:0000269|PubMed:16456541, ECO:0000269|PubMed:22565310}.
uniprot
proteins
mass_dalton
16903
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Thr-18, Thr-123 and Ser-126 by MAPK1/ERK2 and probably MAPK3/ERK1. Upon phosphorylation by MAPK1/ERK2 and MAPK3/ERK1, acquires the ability to inhibit cell death induced by various stimuli. {ECO:0000269|PubMed:12356731}.; PTM: Glycosylated.
uniprot
proteins
protein_family
IER3 family
uniprot
proteins
pubmed
12356731
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16456541
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
22565310
uniprot
proteins
pubmed
8603392
uniprot
proteins
pubmed
8653710
uniprot
proteins
pubmed
9196025
uniprot
proteins
sequence_length
156
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:12356731}; Single-pass type II membrane protein {ECO:0000269|PubMed:12356731}.
uniprot
proteins
transmembrane_region
TRANSMEM 83..99; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins