Tpk1
entrez
29807
canonical
uniprot
Q9R0M5
canonical
ensembl
ENSMUSG00000029735
resolver
ensp
ENSMUSP00000065631
resolver
ensp
ENSMUSP00000110291
resolver
ensp
ENSMUSP00000306916
resolver
ensp
ENSMUSP00000306921
resolver
genesymbol
Tpk1
resolver
uniprot
Q3UWB5
resolver
uniprot
Q8CAB5
resolver
uniprot
Q8CEE8
resolver
uniprot
Q8R1Q6
resolver
uniprot_entry
TPK1_MOUSE
resolver
uniprot_sec
Q3UWB5
resolver
uniprot_sec
Q8CAB5
resolver
uniprot_sec
Q8CEE8
resolver
uniprot_sec
Q8R1Q6
resolver
amino_acid_sequence
MEHAFTPLEPLLPTGNLKYCLVVLNQPLDARFRHLWKKALLRACADGGANHLYDLTEGERESFLPEFVSGDFDSIRPEVKEYYTKKGCDLISTPDQDHTDFTKCLQVLQRKIEEKELQVDVIVTLGGLGGRFDQIMASVNTLFQATHITPVPIIIIQKDSLIYLLQPGKHRLHVDTGMEGSWCGLIPVGQPCNQVTTTGLKWNLTNDVLGFGTLVSTSNTYDGSGLVTVETDHPLLWTMAIKS
uniprot
proteins
ec_number
2.7.6.-
uniprot
proteins
function
FUNCTION: Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate (TPP) utilizing UTP and therefore links the biosynthesis of TPP to pyrimidines metabolism (PubMed:38547260). By producing thiamine pyrophosphate, a cofactor of the mitochondrial pyruvate dehydrogenase indirectly regulates pyruvate oxidation and lipogenesis (PubMed:38547260). Although it can also catalyze thiamine phosphorylation using ATP and CTP in vitro, it does so with significantly lower efficiency and without physiological relevance evidence (PubMed:10567383, PubMed:16365036, PubMed:38547260). {ECO:0000269|PubMed:10567383, ECO:0000269|PubMed:16365036, ECO:0000269|PubMed:38547260}.
uniprot
proteins
mass_dalton
27068
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine: step 1/1. {ECO:0000269|PubMed:38547260}.
uniprot
proteins
protein_family
Thiamine pyrophosphokinase family
uniprot
proteins
pubmed
10567383
uniprot
proteins
pubmed
11419946
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16365036
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
38547260
uniprot
proteins
sequence_length
243
uniprot
proteins