Gucy2f
entrez
245650
canonical
uniprot
Q5SDA5
canonical
ensembl
ENSMUSG00000042282
resolver
ensp
ENSMUSP00000044521
resolver
ensp
ENSMUSP00000305216
resolver
enst
ENSMUST00000042530
resolver
genesymbol
Gucy2f
resolver
uniprot
Q8BLL8
resolver
uniprot_entry
GUC2F_MOUSE
resolver
uniprot_sec
Q8BLL8
resolver
activity_regulation
ACTIVITY REGULATION: Activated by GUCA1B when free calcium ions concentration is low, and inhibited by GUCA1B when free calcium ions concentration is high (By similarity). Inhibited by RD3 (By similarity). {ECO:0000250|UniProtKB:O02740, ECO:0000250|UniProtKB:P51841}.
uniprot
proteins
amino_acid_sequence
MFLGPWPFSRLLSWFAISSRLSGQHGLPSSKFLRCLCLLALLPLLRWGQALPYKIGVIGPWTCDPFFSKALPEVAAALAIERISRDKTFDRSYSFEYVILNEDCQTSKALASFISHQQMASGFVGPANPGFCEAASLLGTSWDKGIFSWACVNHELDNKHSFPTFSRTLPSPIRVLVTVMKYFQWAHAGVISSDEDIWMHTANRVSSALRSQGLPVGVVLTSGRDSQSIQKALQQIRQADRIRIIIMCMHSALIGGETQTHFLELAHDLKMTDGTYVFVPYDVLLYSLPYKHSPYQVLRNNPKLREAYDAVLTITVESHEKTFYEAYAEAAARGEIPEKPDSNQVSPLFGTIYNSIYFIAQAMNNAMKKNGRASAASLVQHSRNMQFYGFNQLIKTDSNGNGISEYVILDTNGKEWELRGTYTVDMETELLRFRGTPIHFPGGRPTSADAKCWFAERKICQGGIDPALAMMVCFALLIALLSINGFAYFIRRRINKIQLIKGPNRILLTLEDVTFINPHFGSKRGSRASVSFQIISEVQSGRSPRLSFSSGSLTPATYENSNIAIYEGDWVWLKKFPPGDFGDIKSIKSSASDVFEMMKDLRHENVNPLLGFFYDSGMFAIVSEFCSRRSLEDILTNDDVKLDWMFKSSLLLDLIKGMKYLHHREFIHGRLKSRNCVVDGRFVLKVTDYGFNDILEMLRLSEEEPSEEELLWTAPELLRAPGGIRLGSFAGDVYSFAIIMQEVMVRGAPFCMMDLPAKEIIDRLKMPPPVYRPVVSPEYAPAECLQLMKQCWAEASEQRPTFDEIFNQFKTFNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEIEKQKTEKLLTQMLPLSVAESLKKGCTVEPEGFDLVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPKRNGSRHAAEIANMSLDILSSVGTFKMRHMPEVPVRIRIGLHSGPVVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVSLSTVTILQTLSEGYEVELRGRTELKGKGTEETFWLVGKKGFTKPLPVPPPVGKDGQVGHGLQPAEIAAFQRRKAERQLVRNKP
uniprot
proteins
ec_number
4.6.1.2
uniprot
proteins
function
FUNCTION: Responsible for the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors (By similarity). Plays an essential role in phototransduction, by mediating cGMP replenishment. May also participate in the trafficking of membrane-associated proteins to the photoreceptor outer segment membrane (PubMed:17255100). {ECO:0000250|UniProtKB:O02740, ECO:0000269|PubMed:17255100}.
uniprot
proteins
mass_dalton
124425
uniprot
proteins
post_translational_modification
PTM: There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds. {ECO:0000250}.
uniprot
proteins
protein_family
Adenylyl cyclase class-4/guanylyl cyclase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15718098
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17255100
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21078983
uniprot
proteins
sequence_length
1108
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P51842}; Single-pass type I membrane protein {ECO:0000255}. Photoreceptor outer segment membrane {ECO:0000269|PubMed:21078983}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 470..490; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins