MYT1L
entrez
23040
canonical
uniprot
Q9UL68
canonical
ensembl
ENSG00000186487
resolver
ensp
ENSP00000382114
resolver
ensp
ENSP00000396103
resolver
ensp
ENSP00000496210
resolver
ensp
ENSP00000496831
resolver
ensp
ENSP00000496922
resolver
ensp
ENSP00000496986
resolver
ensp
ENSP00000497017
resolver
ensp
ENSP00000497068
resolver
ensp
ENSP00000497115
resolver
ensp
ENSP00000497206
resolver
ensp
ENSP00000497273
resolver
ensp
ENSP00000497479
resolver
ensp
ENSP00000497493
resolver
ensp
ENSP00000497722
resolver
ensp
ENSP00000498096
resolver
enst
ENST00000644820
resolver
enst
ENST00000647755
resolver
enst
ENST00000648318
resolver
enst
ENST00000648339
resolver
enst
ENST00000648665
resolver
enst
ENST00000649663
resolver
enst
ENST00000650485
resolver
genesymbol
MYT1L
resolver
genesymbol_syn
KIAA1106
resolver
hgnc
HGNC:7623
resolver
uniprot
A0A2R8YF72
resolver
uniprot
A0A3B3IRM3
resolver
uniprot
A0A3B3IRX5
resolver
uniprot
A0A3B3IS14
resolver
uniprot
A0A3B3IS61
resolver
uniprot
A0A3B3ISW5
resolver
uniprot
A7E2C7
resolver
uniprot
B2RP54
resolver
uniprot
Q6IQ17
resolver
uniprot
Q9UPP6
resolver
uniprot_entry
A0A2R8YF72_HUMAN
resolver
uniprot_entry
A0A3B3IRM3_HUMAN
resolver
uniprot_entry
A0A3B3IRX5_HUMAN
resolver
uniprot_entry
A0A3B3IS14_HUMAN
resolver
uniprot_entry
A0A3B3IS61_HUMAN
resolver
uniprot_entry
A0A3B3ISW5_HUMAN
resolver
uniprot_entry
MYT1L_HUMAN
resolver
uniprot_sec
A7E2C7
resolver
uniprot_sec
B2RP54
resolver
uniprot_sec
Q6IQ17
resolver
uniprot_sec
Q9UPP6
resolver
amino_acid_sequence
MEVDTEEKRHRTRSKGVRVPVEPAIQELFSCPTPGCDGSGHVSGKYARHRSVYGCPLAKKRKTQDKQPQEPAPKRKPFAVKADSSSVDECDDSDGTEDMDEKEEDEGEEYSEDNDEPGDEDEEDEEGDREEEEEIEEEDEDDDEDGEDVEDEEEEEEEEEEEEEEEENEDHQMNCHNTRIMQDTEKDDNNNDEYDNYDELVAKSLLNLGKIAEDAAYRARTESEMNSNTSNSLEDDSDKNENLGRKSELSLDLDSDVVRETVDSLKLLAQGHGVVLSENMNDRNYADSMSQQDSRNMNYVMLGKPMNNGLMEKMVEESDEEVCLSSLECLRNQCFDLARKLSETNPQERNPQQNMNIRQHVRPEEDFPGRTPDRNYSDMLNLMRLEEQLSPRSRVFASCAKEDGCHERDDDTTSVNSDRSEEVFDMTKGNLTLLEKAIALETERAKAMREKMAMEAGRRDNMRSYEDQSPRQLPGEDRKPKSSDSHVKKPYYGKDPSRTEKKESKCPTPGCDGTGHVTGLYPHHRSLSGCPHKDRVPPEILAMHESVLKCPTPGCTGRGHVNSNRNSHRSLSGCPIAAAEKLAKAQEKHQSCDVSKSSQASDRVLRPMCFVKQLEIPQYGYRNNVPTTTPRSNLAKELEKYSKTSFEYNSYDNHTYGKRAIAPKVQTRDISPKGYDDAKRYCKDPSPSSSSTSSYAPSSSSNLSCGGGSSASSTCSKSSFDYTHDMEAAHMAATAILNLSTRCREMPQNLSTKPQDLCATRNPDMEVDENGTLDLSMNKQRPRDSCCPILTPLEPMSPQQQAVMNNRCFQLGEGDCWDLPVDYTKMKPRRIDEDESKDITPEDLDPFQEALEERRYPGEVTIPSPKPKYPQCKESKKDLITLSGCPLADKSIRSMLATSSQELKCPTPGCDGSGHITGNYASHRSLSGCPRAKKSGIRIAQSKEDKEDQEPIRCPVPGCDGQGHITGKYASHRSASGCPLAAKRQKDGYLNGSQFSWKSVKTEGMSCPTPGCDGSGHVSGSFLTHRSLSGCPRATSAMKKAKLSGEQMLTIKQRASNGIENDEEIKQLDEEIKELNESNSQMEADMIKLRTQITTMESNLKTIEEENKVIEQQNESLLHELANLSQSLIHSLANIQLPHMDPINEQNFDAYVTTLTEMYTNQDRYQSPENKALLENIKQAVRGIQV
uniprot
proteins
disease_involvement
DISEASE: Intellectual developmental disorder, autosomal dominant 39 (MRD39) [MIM:616521]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD39 patients show delayed psychomotor development and autistic features. {ECO:0000269|PubMed:23033978, ECO:0000269|PubMed:23160955}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Transcription factor that plays a key role in neuronal differentiation by specifically repressing expression of non-neuronal genes during neuron differentiation. In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs. Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B. The 5'-AAGTT-3' core motif is absent from the promoter of neural genes. {ECO:0000250|UniProtKB:P97500}.
uniprot
proteins
mass_dalton
133043
uniprot
proteins
protein_family
MYT1 family
uniprot
proteins
pubmed
10470851
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
23033978
uniprot
proteins
pubmed
23160955
uniprot
proteins
sequence_length
1186
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P97500}. Chromosome {ECO:0000250|UniProtKB:P97500}. Note=Preferentially binds to DNA binding sites that are in an open chromatin configuration. {ECO:0000250|UniProtKB:P97500}.
uniprot
proteins