Shld3
entrez
113002583
canonical
uniprot
Q9CZV2
canonical
ensembl
ENSMUSG00000118537
resolver
ensp
ENSMUSP00000159139
resolver
enst
ENSMUST00000133280
resolver
genesymbol
Shld3
resolver
genesymbol_syn
Rinn1
resolver
uniprot_entry
SHLD3_MOUSE
resolver
amino_acid_sequence
MDSCRMTTEVILHYRPYENDPKQLAKIAENVIQDFPTHPLPRFIPWFPYDESKLPLKPERLPPVISEEAAESVKQYLAISEPGVKSQSYDCTVDLLEFQPSSKLQHFIQSHTVKEQTNAAHLDKNSGKEKQHKQRSWSVSLASSHCPEKIFPLSRKLQASLRTLHLHSFHRARWTLEYSVCNNQTLEDIWTKLNRLIRRDELPSCNATIQRQLGQIWVFCDIKCCEYVGNLLKERLSLIGKIDLFVHKYGVIFSM
uniprot
proteins
function
FUNCTION: Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection. Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres. {ECO:0000250|UniProtKB:Q6ZNX1}.
uniprot
proteins
mass_dalton
29675
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
255
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q6ZNX1}. Note=Recruited to sites of chromosomal double-stranded breaks during G1 and S phase of the cell cycle. {ECO:0000250|UniProtKB:Q6ZNX1}.
uniprot
proteins