Elavl4
entrez
432358
canonical
uniprot
O09032
canonical
ensembl
ENSRNOG00000023601
resolver
ensembl
ENSRNOG00055028847
resolver
ensembl
ENSRNOG00060025167
resolver
ensembl
ENSRNOG00065026607
resolver
ensp
ENSRNOP00000037614
resolver
ensp
ENSRNOP00000076930
resolver
ensp
ENSRNOP00000086190
resolver
ensp
ENSRNOP00000095267
resolver
enst
ENSRNOT00000035252
resolver
enst
ENSRNOT00000101036
resolver
enst
ENSRNOT00000101531
resolver
enst
ENSRNOT00000109917
resolver
genesymbol
Elavl4
resolver
genesymbol_syn
Hud
resolver
uniprot
A0A140TAF2
resolver
uniprot
A0A8I5Y0H9
resolver
uniprot
A0A8I6A344
resolver
uniprot
A0A8I6APY9
resolver
uniprot
B0BMT8
resolver
uniprot_entry
A0A8I5Y0H9_RAT
resolver
uniprot_entry
A0A8I6A344_RAT
resolver
uniprot_entry
A0A8I6APY9_RAT
resolver
uniprot_entry
B0BMT8_RAT
resolver
uniprot_entry
ELAV4_RAT
resolver
uniprot_sec
A0A140TAF2
resolver
amino_acid_sequence
MEWNGLKMIISTMEPQVSNGPTSNTSNGPSSNNRNCPSPMQTGAATDDSKTNLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINTLNGLRLQTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPSGATEPITVKFANNPSQKSSQALLSQLYQSPNRRYPGPLHHQAQRFRLDNLLNMAYGVKRLMSGPVPPSACPPRFSPITIDGMTSLVGMNIPGHTGTGWCIFVYNLSPDSDESVLWQLFGPFGAVNNVKVIRDFNTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKAHKS
uniprot
proteins
function
FUNCTION: RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs (PubMed:10982410, PubMed:16508003, PubMed:17577668). Plays a role in the regulation of mRNA stability, alternative splicing and translation (PubMed:10982410, PubMed:16508003, PubMed:17577668). Binds to AU-rich element (ARE) sequences in the 3' untranslated region (UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA (PubMed:10982410). Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function (By similarity). By binding to the mRNA 3'UTR, decreases mRNA deadenylation and thereby contributes to the stabilization of mRNA molecules and their protection from decay (By similarity). Also binds to the polyadenylated (poly(A)) tail in the 3'UTR of mRNA, thereby increasing its affinity for mRNA binding (By similarity). Mainly plays a role in neuron-specific RNA processing by stabilization of mRNAs such as GAP43, ACHE and mRNAs of other neuronal proteins, thereby contributing to the differentiation of neural progenitor cells, nervous system development, learning and memory mechanisms (PubMed:10982410, PubMed:17577668). Involved in the negative regulation of the proliferative activity of neuronal stem cells and in the positive regulation of neuronal differentiation of neural progenitor cells (By similarity). Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone of the hippocampus by binding to and stabilizing SATB1 mRNA (By similarity). Binds and stabilizes MSI1 mRNA in neural stem cells (By similarity). Exhibits increased binding to ACHE mRNA during neuronal differentiation, thereby stabilizing ACHE mRNA and enhancing its expression (By similarity). Protects CDKN1A mRNA from decay by binding to its 3'-UTR (PubMed:16508003). May bind to APP and BACE1 mRNAS and the BACE1AS lncRNA and enhance their stabilization (By similarity). Plays a role in neurite outgrowth and in the establishment and maturation of dendritic arbors, thereby contributing to neocortical and hippocampal circuitry function (By similarity). Stabilizes GAP43 mRNA and protects it from decay during postembryonic development in the brain (PubMed:10982410, PubMed:17234598). By promoting the stabilization of GAP43 mRNA, plays a role in NGF-mediated neurite outgrowth (PubMed:10982410). Binds to BDNF long 3'UTR mRNA, thereby leading to its stabilization and increased dendritic translation after activation of PKC (PubMed:25692578). By increasing translation of BDNF after nerve injury, may contribute to nerve regeneration (By similarity). Acts as a stabilizing factor by binding to the 3'UTR of NOVA1 mRNA, thereby increasing its translation and enhancing its functional activity in neuron-specific splicing (By similarity). Stimulates translation of mRNA in a poly(A)- and cap-dependent manner, possibly by associating with the EIF4F cap-binding complex (By similarity). May also negatively regulate translation by binding to the 5'UTR of Ins2 mRNA, thereby repressing its translation (By similarity). Upon glucose stimulation, Ins2 mRNA is released form ELAVL4 and translational inhibition is abolished (By similarity). Also plays a role in the regulation of alternative splicing (By similarity). May regulate alternative splicing of CALCA pre-mRNA into Calcitonin and calcitonin gene-related peptide 1 (CGRP) by competing with splicing regulator TIAR for binding to U-rich sequences of CALCA pre-mRNA (By similarity). {ECO:0000250|UniProtKB:P26378, ECO:0000250|UniProtKB:Q61701, ECO:0000269|PubMed:10982410, ECO:0000269|PubMed:16508003, ECO:0000269|PubMed:17234598, ECO:0000269|PubMed:17577668, ECO:0000269|PubMed:25692578}.
uniprot
proteins
mass_dalton
42368
uniprot
proteins
post_translational_modification
PTM: Methylated by CARM1, which leads to reduced RNA-binding activity and enhanced interaction with SMN (By similarity). Methylation at Arg-248 by CARM1 weakens protective binding to the 3'-UTR of CDKN1A mRNA and down-regulates CDKN1A protein expression, thereby maintaining cells in a proliferative state (PubMed:16508003). Methylation is inhibited by NGF, which facilitates neurite outgrowth (PubMed:16508003). {ECO:0000250|UniProtKB:P26378, ECO:0000269|PubMed:16508003}.
uniprot
proteins
protein_family
RRM elav family
uniprot
proteins
pubmed
10982410
uniprot
proteins
pubmed
11948657
uniprot
proteins
pubmed
12957493
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15519747
uniprot
proteins
pubmed
16508003
uniprot
proteins
pubmed
16554442
uniprot
proteins
pubmed
17234598
uniprot
proteins
pubmed
17577668
uniprot
proteins
pubmed
21389246
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
25692578
uniprot
proteins
pubmed
8717365
uniprot
proteins
sequence_length
385
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11948657, ECO:0000269|PubMed:12957493, ECO:0000269|PubMed:15519747, ECO:0000269|PubMed:16554442}. Perikaryon {ECO:0000269|PubMed:12957493, ECO:0000269|PubMed:25692578}. Cell projection, axon {ECO:0000250|UniProtKB:Q61701}. Cell projection, dendrite {ECO:0000269|PubMed:15519747}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q61701}. Note=Co-localizes with ribosomal RNA in polysomes. {ECO:0000269|PubMed:12957493, ECO:0000269|PubMed:15519747}.
uniprot
proteins