Nploc4
entrez
140639
canonical
uniprot
Q9ES54
canonical
ensembl
ENSRNOG00000036698
resolver
ensp
ENSRNOP00000068982
resolver
ensp
ENSRNOP00000100116
resolver
enst
ENSRNOT00000168258
resolver
genesymbol
Nploc4
resolver
genesymbol_syn
Npl4
resolver
uniprot
A0ABK0L642
resolver
uniprot
Q3T1J3
resolver
uniprot_entry
A0ABK0L642_RAT
resolver
uniprot_entry
NPL4_RAT
resolver
uniprot_sec
Q3T1J3
resolver
amino_acid_sequence
MAESIIIRVQSPDGVKRITATKRETAATFLKKVAKEFGFQNNGFSVYINRNKTGEITASSSKSLHLLKIKHGDLLFLFPSSLAGPSSEMETSTSVGLKAFGAPHVVEDEIDQYLSKQDGKIYRSRDPQLCRHGPLGKCVHCVPLEPFDEDYLNHLEPPVKHMSFHAYIRKLTGGADKGKFVALENISCKIKSGCEGHLPWPNGICTKCQPSAITLNRQKYRHVDNIMFENHTVADRFLDFWRKTGNQHFGYLYGRYTEHKDIPLGIRAEVAAIYEPPQIGTQNSLELLEDPKAEVVDEIASKLGLRKVGWIFTDLVSEDTRKGTVRYSRNKDTYFLSSEECITAGDFQNKHPNICRLSPDGHFGSKFVTAVATGGPDNQVHFEGYQVSNQCMALVRDECLLPCKDAPELGYAKESSSEQYVPDVFYKDIDKFGNEITQLARPLPVEYLIIDITTTFPKDPVYTFSISQNPFPIENRDVLGETQDFHSLATYLSQNTSSVFLDTISDFHLLLFLVTNEVMPLQDSISLLLEAVRTRNEELAQTWKKSEQWATIEQLCSTVGVQLPGLHEFGAVGGSARAATSAMWACQHCTFMNQPGTGHCEMCSLPRT
uniprot
proteins
function
FUNCTION: The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (PubMed:10811609, PubMed:11740563, PubMed:11781570, PubMed:12411482, PubMed:12644454, PubMed:14636562). Acts as a negative regulator of type I interferon production via the complex formed with VCP and UFD1, which binds to RIGI and recruits RNF125 to promote ubiquitination and degradation of RIGI (By similarity). {ECO:0000250|UniProtKB:Q8TAT6, ECO:0000269|PubMed:10811609, ECO:0000269|PubMed:11740563, ECO:0000269|PubMed:11781570, ECO:0000269|PubMed:12411482, ECO:0000269|PubMed:12644454, ECO:0000269|PubMed:14636562}.
uniprot
proteins
mass_dalton
68056
uniprot
proteins
pathway_participation
PATHWAY: Protein degradation; proteasomal ubiquitin-dependent pathway.
uniprot
proteins
protein_family
NPL4 family
uniprot
proteins
pubmed
10811609
uniprot
proteins
pubmed
11740563
uniprot
proteins
pubmed
11781570
uniprot
proteins
pubmed
12411482
uniprot
proteins
pubmed
12644454
uniprot
proteins
pubmed
14636562
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
608
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10811609}. Endoplasmic reticulum {ECO:0000269|PubMed:10811609}. Nucleus {ECO:0000269|PubMed:10811609}. Note=Associated with the endoplasmic reticulum and nuclear.
uniprot
proteins