Kcnk16
entrez
74571
canonical
uniprot
G5E845
canonical
ensembl
ENSMUSG00000023387
resolver
ensp
ENSMUSP00000024155
resolver
enst
ENSMUST00000024155
resolver
genesymbol
Kcnk16
resolver
uniprot_entry
KCNKG_MOUSE
resolver
amino_acid_sequence
MPRAGVCGCWGGQVLPLLLAYICYLLLGATIFQLLEKQAEAQSRDQFQLEKLRFLENYTCLDQQALEQFVQVILEAWVKGVNPKGNSTNPSNWDFGSSFFFAGTVVTTIGYGNLAPSTEAGQVFCVFYALMGIPLNVVFLNHLGTGLRAHLTTLDRWEDHPRHSQLLQVLGLALFLTLGTLVILIFPPMFFSHVEGWSFREGFYFAFITLSTIGFGDYVVGTDPSKHYIAVYRSLAAIWILLGLAWLAVVLSLGSLLLHRCSRLWQLIRGLDLKDGAAPDSEPRSQKIPISA
uniprot
proteins
function
FUNCTION: K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate (By similarity). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (By similarity). In pancreatic islets, conducts K(+) countercurrents for Ca(2+) release from the endoplasmic reticulum (ER) and regulates the frequency and duration of cytosolic Ca(2+) oscillations coupled to secretion of pancreatic hormones (PubMed:26239056, PubMed:28928238, PubMed:29402588). In pancreatic beta cells, drives ER Ca(2+) efflux, which in turn activates Ca(2+)-dependent plasma membrane K(+) slow currents and cytosolic Ca(2+) influx, overall contributing to synchronous cytosolic Ca(2+) oscillations. Limits glucose-induced cytosolic Ca(2+) oscillations coupled to second-phase INS secretion (PubMed:26239056, PubMed:28928238, PubMed:29348619). Contributes to beta cell adaptation to acute inflammation by maintaining normal cytosolic Ca(2+) levels and INS secretion (PubMed:29348619). May regulate beta cell mitochondrial Ca(2+) levels either indirectly via ER Ca(2+) efflux or directly by hyperpolarizing the mitochondrial membrane potential. Limits mitochondrial Ca(2+) oscillations and ATP production involved in glucose homeostasis upon metabolic stress (PubMed:26239056). In pancreatic delta cells, limits Ca(2+)-induced Ca(2+)-release involved in somatostatin secretion and modulates islet paracrine signaling involved in glucagon secretion (PubMed:29402588). Permeable to other monovalent cations such as Rb(+) and Cs(+) (By similarity). {ECO:0000250|UniProtKB:Q96T54, ECO:0000250|UniProtKB:Q96T55, ECO:0000269|PubMed:26239056, ECO:0000269|PubMed:28928238, ECO:0000269|PubMed:29348619, ECO:0000269|PubMed:29402588}.
uniprot
proteins
mass_dalton
32462
uniprot
proteins
protein_family
Two pore domain potassium channel (TC 1.A.1.8) family
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
26239056
uniprot
proteins
pubmed
28928238
uniprot
proteins
pubmed
29348619
uniprot
proteins
pubmed
29402588
uniprot
proteins
pubmed
38206814
uniprot
proteins
sequence_length
292
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q96T55}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:28928238, ECO:0000305|PubMed:29402588}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion inner membrane {ECO:0000305|PubMed:38206814}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 14..34; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 120..140; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 166..186; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 238..258; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins