TCF25
entrez
22980
canonical
uniprot
Q9BQ70
canonical
ensembl
ENSG00000141002
resolver
ensp
ENSP00000263346
resolver
ensp
ENSP00000491638
resolver
enst
ENST00000263346
resolver
enst
ENST00000640279
resolver
genesymbol
TCF25
resolver
genesymbol_syn
KIAA1049
resolver
genesymbol_syn
NULP1
resolver
hgnc
HGNC:29181
resolver
uniprot
Q2MK75
resolver
uniprot
Q9UPV3
resolver
uniprot_entry
TCF25_HUMAN
resolver
uniprot_sec
Q2MK75
resolver
uniprot_sec
Q9UPV3
resolver
amino_acid_sequence
MSRRALRRLRGEQRGQEPLGPGALHFDLRDDDDAEEEGPKRELGVRRPGGAGKEGVRVNNRFELINIDDLEDDPVVNGERSGCALTDAVAPGNKGRGQRGNTESKTDGDDTETVPSEQSHASGKLRKKKKKQKNKKSSTGEASENGLEDIDRILERIEDSTGLNRPGPAPLSSRKHVLYVEHRHLNPDTELKRYFGARAILGEQRPRQRQRVYPKCTWLTTPKSTWPRYSKPGLSMRLLESKKGLSFFAFEHSEEYQQAQHKFLVAVESMEPNNIVVLLQTSPYHVDSLLQLSDACRFQEDQEMARDLVERALYSMECAFHPLFSLTSGACRLDYRRPENRSFYLALYKQMSFLEKRGCPRTALEYCKLILSLEPDEDPLCMLLLIDHLALRARNYEYLIRLFQEWEAHRNLSQLPNFAFSVPLAYFLLSQQTDLPECEQSSARQKASLLIQQALTMFPGVLLPLLESCSVRPDASVSSHRFFGPNAEISQPPALSQLVNLYLGRSHFLWKEPATMSWLEENVHEVLQAVDAGDPAVEACENRRKVLYQRAPRNIHRHVILSEIKEAVAALPPDVTTQSVMGFDPLPPSDTIYSYVRPERLSPISHGNTIALFFRSLLPNYTMEGERPEEGVAGGLNRNQGLNRLMLAVRDMMANFHLNDLEAPHEDDAEGEGEWD
uniprot
proteins
function
FUNCTION: Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:30244831). In the RQC complex, required to promote formation of 'Lys-48'-linked polyubiquitin chains during ubiquitination of incompletely synthesized proteins by LTN1 (PubMed:30244831). May negatively regulate the calcineurin-NFAT signaling cascade by suppressing the activity of transcription factor NFATC4 (By similarity). May play a role in cell death control (By similarity). {ECO:0000250|UniProtKB:A0A8I6ASZ5, ECO:0000250|UniProtKB:Q8R3L2, ECO:0000269|PubMed:30244831}.
uniprot
proteins
mass_dalton
76667
uniprot
proteins
protein_family
TCF25 family
uniprot
proteins
pubmed
10470851
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16574069
uniprot
proteins
pubmed
18068114
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
30244831
uniprot
proteins
pubmed
32805187
uniprot
proteins
sequence_length
676
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16574069, ECO:0000269|PubMed:18068114}. Cytoplasm, cytosol {ECO:0000269|PubMed:18068114}. Note=Mainly nuclear. {ECO:0000269|PubMed:18068114}.
uniprot
proteins