DBF4
entrez
10926
canonical
uniprot
Q9UBU7
canonical
ensembl
ENSG00000006634
resolver
ensp
ENSP00000265728
resolver
ensp
ENSP00000389397
resolver
enst
ENST00000430279
resolver
genesymbol
DBF4
resolver
genesymbol_syn
ASK
resolver
genesymbol_syn
DBF4A
resolver
genesymbol_syn
ZDBF1
resolver
hgnc
HGNC:17364
resolver
uniprot
A4D1D8
resolver
uniprot
A8K954
resolver
uniprot
B4DXK0
resolver
uniprot
B7Z8C6
resolver
uniprot
F6S2W1
resolver
uniprot
O75226
resolver
uniprot
Q75MS6
resolver
uniprot
Q75N01
resolver
uniprot
Q9Y2M6
resolver
uniprot_entry
B4DXK0_HUMAN
resolver
uniprot_entry
B7Z8C6_HUMAN
resolver
uniprot_entry
DBF4A_HUMAN
resolver
uniprot_entry
F6S2W1_HUMAN
resolver
uniprot_sec
A4D1D8
resolver
uniprot_sec
A8K954
resolver
uniprot_sec
O75226
resolver
uniprot_sec
Q75MS6
resolver
uniprot_sec
Q75N01
resolver
uniprot_sec
Q9Y2M6
resolver
amino_acid_sequence
MNSGAMRIHSKGHFQGGIQVKNEKNRPSLKSLKTDNRPEKSKCKPLWGKVFYLDLPSVTISEKLQKDIKDLGGRVEEFLSKDISYLISNKKEAKFAQTLGRISPVPSPESAYTAETTSPHPSHDGSSFKSPDTVCLSRGKLLVEKAIKDHDFIPSNSILSNALSWGVKILHIDDIRYYIEQKKKELYLLKKSSTSVRDGGKRVGSGAQKTRTGRLKKPFVKVEDMSQLYRPFYLQLTNMPFINYSIQKPCSPFDVDKPSSMQKQTQVKLRIQTDGDKYGGTSIQLQLKEKKKKGYCECCLQKYEDLETHLLSEQHRNFAQSNQYQVVDDIVSKLVFDFVEYEKDTPKKKRIKYSVGSLSPVSASVLKKTEQKEKVELQHISQKDCQEDDTTVKEQNFLYKETQETEKKLLFISEPIPHPSNELRGLNEKMSNKCSMLSTAEDDIRQNFTQLPLHKNKQECILDISEHTLSENDLEELRVDHYKCNIQASVHVSDFSTDNSGSQPKQKSDTVLFPAKDLKEKDLHSIFTHDSGLITINSSQEHLTVQAKAPFHTPPEEPNECDFKNMDSLPSGKIHRKVKIILGRNRKENLEPNAEFDKRTEFITQEENRICSSPVQSLLDLFQTSEEKSEFLGFTSYTEKSGICNVLDIWEEENSDNLLTAFFSSPSTSTFTGF
uniprot
proteins
function
FUNCTION: Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA replication during cell cycle. {ECO:0000269|PubMed:10373557, ECO:0000269|PubMed:10523313, ECO:0000269|PubMed:17062569}.
uniprot
proteins
mass_dalton
76858
uniprot
proteins
mutagenesis
MUTAGEN 625; /note="S->D: Phosphomimetic mutant. Increased interaction with PSIP1."; /evidence="ECO:0000269|PubMed:29997176"; MUTAGEN 631; /note="F->A: Loss of interaction with PSIP1; when associated with A-634."; /evidence="ECO:0000269|PubMed:29997176"; MUTAGEN 634; /note="F->A: Loss of interaction with PSIP1; when associated with A-631."; /evidence="ECO:0000269|PubMed:29997176"; MUTAGEN 667; /note="S->D: Phosphomimetic mutant. Increased interaction with PSIP1; when associated with D-669."; /evidence="ECO:0000269|PubMed:29997176"; MUTAGEN 669; /note="S->D: Phosphomimetic mutant. Increased interaction with PSIP1; when associated with D-667."; /evidence="ECO:0000269|PubMed:29997176
uniprot
proteins
post_translational_modification
PTM: Phosphorylation increases its interaction with PSIP1. {ECO:0000269|PubMed:29997176}.
uniprot
proteins
pubmed
10373557
uniprot
proteins
pubmed
10523313
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15374998
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17062569
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
29997176
uniprot
proteins
sequence_length
674
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10373557}.
uniprot
proteins