Noto
entrez
384452
canonical
uniprot
Q5TIS6
canonical
ensembl
ENSMUSG00000068302
resolver
ensp
ENSMUSP00000087006
resolver
ensp
ENSMUSP00000134424
resolver
enst
ENSMUST00000089578
resolver
genesymbol
Noto
resolver
genesymbol_syn
Not
resolver
uniprot_entry
NOTO_MOUSE
resolver
amino_acid_sequence
MSSPAPSGTQVQPGSLRPCPGAVSPVVPRRLARGRLESSFSVEAILARPKTRELAATSLPLSTCTSLNLLGAVSQYGVLPWVCSTGSWLPAYLSVGVYPLCSMSCVPGLNVTHHQQGLRLTGSELPYCLGPLKWAPTVDLRDHGTERHTKRVRTTFNLQQLQELEKVFAKQHNLVGKERAQLAARLHLTENQVRIWFQNRRVKYQKQQKLKLPSSSVMEEPSSSSDGNIQSEDAELGIGS
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Noto are the cause of the truncate (tc) phenotype. Truncate (tc) is a recessive mutation that affects the development of the caudal notochord. Mice homozygous for tc are viable but viability is reduced, which is attributed at least in part to spinal injury in the sacral and lower lumbar region. {ECO:0000269|PubMed:15231714}.
uniprot
proteins
function
FUNCTION: Transcription factor that controls node morphogenesis (PubMed:15231714, PubMed:17884984, PubMed:18061569, PubMed:22357932). Acts downstream of both FOXA2 and Brachyury (T) during notochord development (PubMed:15231714). Is essential for cilia formation in the posterior notochord (PNC) and for left-right patterning; acts upstream of FOXJ1 and RFX3 in this process and is required for the expression of various components important for axonemal assembly and function (PubMed:17884984). Plays a role in regulating axial versus paraxial cell fate (PubMed:18061569). Activates the transcription of ciliary proteins C11orf97 homolog, FAM183B and SPACA9 in the embryonic ventral node (PubMed:27914912). {ECO:0000269|PubMed:15231714, ECO:0000269|PubMed:17884984, ECO:0000269|PubMed:18061569, ECO:0000269|PubMed:22357932, ECO:0000269|PubMed:27914912}.
uniprot
proteins
mass_dalton
26322
uniprot
proteins
pubmed
15231714
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17884984
uniprot
proteins
pubmed
18061569
uniprot
proteins
pubmed
22357932
uniprot
proteins
pubmed
27914912
uniprot
proteins
sequence_length
240
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
uniprot
proteins