SURF4
entrez
6836
canonical
uniprot
O15260
canonical
ensembl
ENSG00000148248
resolver
ensembl
ENSG00000280951
resolver
ensp
ENSP00000361057
resolver
ensp
ENSP00000419853
resolver
ensp
ENSP00000446061
resolver
ensp
ENSP00000481666
resolver
ensp
ENSP00000483216
resolver
ensp
ENSP00000486033
resolver
ensp
ENSP00000486393
resolver
ensp
ENSP00000545693
resolver
ensp
ENSP00000545694
resolver
enst
ENST00000613129
resolver
enst
ENST00000618229
resolver
enst
ENST00000625213
resolver
enst
ENST00000627384
resolver
genesymbol
SURF4
resolver
genesymbol_syn
SURF-4
resolver
hgnc
HGNC:11476
resolver
uniprot
A0A024R8C4
resolver
uniprot
A0A087WYB1
resolver
uniprot
B7Z1G8
resolver
uniprot
B7Z6A4
resolver
uniprot
B7Z7A8
resolver
uniprot
O60923
resolver
uniprot
Q5T8U6
resolver
uniprot
Q9UNZ0
resolver
uniprot
Q9UNZ1
resolver
uniprot_entry
A0A087WYB1_HUMAN
resolver
uniprot_entry
B7Z1G8_HUMAN
resolver
uniprot_entry
B7Z7A8_HUMAN
resolver
uniprot_entry
SURF4_HUMAN
resolver
uniprot_sec
A0A024R8C4
resolver
uniprot_sec
B7Z6A4
resolver
uniprot_sec
O60923
resolver
uniprot_sec
Q5T8U6
resolver
uniprot_sec
Q9UNZ0
resolver
uniprot_sec
Q9UNZ1
resolver
amino_acid_sequence
MGQNDLMGTAEDFADQFLRVTKQYLPHVARLCLISTFLEDGIRMWFQWSEQRDYIDTTWNCGYLLASSFVFLNLLGQLTGCVLVLSRNFVQYACFGLFGIIALQTIAYSILWDLKFLMRNLALGGGLLLLLAESRSEGKSMFAGVPTMRESSPKQYMQLGGRVLLVLMFMTLLHFDASFFSIVQNIVGTALMILVAIGFKTKLAALTLVVWLFAINVYFNAFWTIPVYKPMHDFLKYDFFQTMSVIGGLLLVVALGPGGVSMDEKKKEW
uniprot
proteins
function
FUNCTION: Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion (PubMed:29643117, PubMed:30251625, PubMed:33186557). Acts as a cargo receptor for lipoproteins bearing both APOB and APOA1, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis (PubMed:29643117, PubMed:33186557). Synergizes with the GTPase SAR1B to mediate transport of circulating lipoproteins (PubMed:33186557). Promotes the secretion of PCSK9 (PubMed:30251625). Also mediates the efficient secretion of erythropoietin (EPO) (PubMed:32989016). May also play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi (PubMed:18287528). {ECO:0000269|PubMed:18287528, ECO:0000269|PubMed:29643117, ECO:0000269|PubMed:30251625, ECO:0000269|PubMed:32989016, ECO:0000269|PubMed:33186557}.
uniprot
proteins
mass_dalton
30394
uniprot
proteins
mutagenesis
MUTAGEN 265..267; /note="KKK->SSS,AAA: Targeted to the Golgi."; /evidence="ECO:0000269|PubMed:18287528, ECO:0000269|PubMed:33186557
uniprot
proteins
protein_family
SURF4 family
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15308636
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18287528
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29251827
uniprot
proteins
pubmed
29643117
uniprot
proteins
pubmed
30251625
uniprot
proteins
pubmed
32989016
uniprot
proteins
pubmed
33186557
uniprot
proteins
pubmed
34015269
uniprot
proteins
pubmed
7540914
uniprot
proteins
pubmed
9740673
uniprot
proteins
sequence_length
269
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15308636, ECO:0000269|PubMed:18287528, ECO:0000269|PubMed:30251625, ECO:0000269|PubMed:33186557}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:18287528}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:18287528, ECO:0000269|PubMed:30251625, ECO:0000269|PubMed:33186557}; Multi-pass membrane protein {ECO:0000255}. Note=Active at endoplasmic reticulum exit sites (ERES) where it is incorporated together with its lipoprotein cargos into COPII-coated vesicles. From the Golgi it is recycled back to the endoplasmic reticulum. {ECO:0000269|PubMed:18287528, ECO:0000269|PubMed:33186557}.
uniprot
proteins
transmembrane_region
TRANSMEM 64..84; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 92..112; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 179..199; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 203..223; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 239..259; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins