Ephx1
entrez
25315
canonical
uniprot
P07687
canonical
ensembl
ENSRNOG00000003515
resolver
ensembl
ENSRNOG00055012533
resolver
ensembl
ENSRNOG00060007277
resolver
ensembl
ENSRNOG00065017103
resolver
ensp
ENSRNOP00000004780
resolver
ensp
ENSRNOP00055017286
resolver
ensp
ENSRNOP00060009017
resolver
ensp
ENSRNOP00065022636
resolver
enst
ENSRNOT00000004780
resolver
enst
ENSRNOT00055021371
resolver
enst
ENSRNOT00060011971
resolver
enst
ENSRNOT00065028582
resolver
genesymbol
Ephx1
resolver
genesymbol_syn
Eph-1
resolver
uniprot_entry
HYEP_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by 10-hydroxystearamide and methoxy-arachidonyl fluorophosphate. {ECO:0000250|UniProtKB:P07099}.
uniprot
proteins
amino_acid_sequence
MWLELVLASLLGFVIYWFVSRDKEETLPLGDGWWGPGSKPSAKEDESIRPFKVETSDEEIKDLHQRIDRFRASPPLEGSRFHYGFNSNYMKKVVSYWRNEFDWRKQVEILNQYPHFKTKIEGLDIHFIHVKPPQLPSGRTPKPLLMVHGWPGSFYEFYKIIPLLTDPKSHGLSDEHVFEVICPSIPGYGYSEASSKKGLNSVATARIFYKLMTRLGFQKFYIQGGDWGSLICTNMAQMVPNHVKGLHLNMAFISRSFYTMTPLLGQRFGRFLGYTEKDIELLYPYKEKVFYSIMRESGYLHIQATKPDTVGCALNDSPVGLAAYILEKFSTWTKSEYRELEDGGLERKFSLDDLLVNIMIYWTTGTIVSSQRYYKENLGQGIMVHKHEGMKVFVPTGFSAFPSELLHAPEKWVKVKYPKLISYSYMERGGHFAAFEEPKLLAQDIRKFVSLAELQ
uniprot
proteins
ec_number
3.3.2.9
uniprot
proteins
function
FUNCTION: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids. Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol (By similarity). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity). {ECO:0000250|UniProtKB:P07099, ECO:0000250|UniProtKB:Q9D379, ECO:0000269|PubMed:9854022}.
uniprot
proteins
mass_dalton
52582
uniprot
proteins
mutagenesis
MUTAGEN 226; /note="D->G,N,S: Loss of catalytic activity and loss of covalent substrate binding."; /evidence="ECO:0000269|PubMed:9854022"; MUTAGEN 388; /note="E->A: Slight decrease in catalytic activity."; /evidence="ECO:0000269|PubMed:9854022"; MUTAGEN 404; /note="E->A: Loss of catalytic activity."; /evidence="ECO:0000269|PubMed:9854022"; MUTAGEN 404; /note="E->D: Increases catalytic activity."; /evidence="ECO:0000269|PubMed:9854022"; MUTAGEN 410; /note="E->A: Slight decrease in catalytic activity."; /evidence="ECO:0000269|PubMed:9854022"; MUTAGEN 431; /note="H->Q: Loss of catalytic activity and severe reduction in substrate binding."; /evidence="ECO:0000269|PubMed:9854022
uniprot
proteins
protein_family
Peptidase S33 family
uniprot
proteins
pubmed
15047867
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
3032949
uniprot
proteins
pubmed
3755318
uniprot
proteins
pubmed
9245728
uniprot
proteins
pubmed
9854022
uniprot
proteins
sequence_length
455
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000269|PubMed:9854022}; Single-pass type III membrane protein {ECO:0000269|PubMed:9245728}. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type III membrane protein {ECO:0000269|PubMed:9245728}.
uniprot
proteins
transmembrane_region
TRANSMEM 1..21; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins