EIF2S2
entrez
8894
canonical
uniprot
P20042
canonical
ensembl
ENSG00000125977
resolver
ensp
ENSP00000364119
resolver
ensp
ENSP00000544876
resolver
ensp
ENSP00000544878
resolver
enst
ENST00000374980
resolver
genesymbol
EIF2S2
resolver
genesymbol_syn
EIF2B
resolver
hgnc
HGNC:3266
resolver
uniprot
Q6IBR8
resolver
uniprot
Q9BVU0
resolver
uniprot
Q9UJE4
resolver
uniprot_entry
IF2B_HUMAN
resolver
uniprot_entry
Q6IBR8_HUMAN
resolver
uniprot_sec
Q9BVU0
resolver
uniprot_sec
Q9UJE4
resolver
amino_acid_sequence
MSGDEMIFDPTMSKKKKKKKKPFMLDEEGDTQTEETQPSETKEVEPEPTEDKDLEADEEDTRKKDASDDLDDLNFFNQKKKKKKTKKIFDIDEAEEGVKDLKIESDVQEPTEPEDDLDIMLGNKKKKKKNVKFPDEDEILEKDEALEDEDNKKDDGISFSNQTGPAWAGSERDYTYEELLNRVFNIMREKNPDMVAGEKRKFVMKPPQVVRVGTKKTSFVNFTDICKLLHRQPKHLLAFLLAELGTSGSIDGNNQLVIKGRFQQKQIENVLRRYIKEYVTCHTCRSPDTILQKDTRLYFLQCETCHSRCSVASIKTGFQAVTGKRAQLRAKAN
uniprot
proteins
function
FUNCTION: Component of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (PubMed:31836389). This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B (By similarity). {ECO:0000250|UniProtKB:P05198, ECO:0000269|PubMed:31836389}.
uniprot
proteins
mass_dalton
38388
uniprot
proteins
protein_family
EIF-2-beta/eIF-5 family
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21745818
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22813744
uniprot
proteins
pubmed
23063529
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25147208
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
3044606
uniprot
proteins
pubmed
31048492
uniprot
proteins
pubmed
31836389
uniprot
proteins
pubmed
32690955
uniprot
proteins
pubmed
34260931
uniprot
proteins
pubmed
35031321
uniprot
proteins
sequence_length
333
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P56329}.
uniprot
proteins