Ets1
entrez
24356
canonical
uniprot
P41156
canonical
ensembl
ENSRNOG00000008941
resolver
ensembl
ENSRNOG00055009032
resolver
ensembl
ENSRNOG00060011460
resolver
ensembl
ENSRNOG00065016494
resolver
ensp
ENSRNOP00000011925
resolver
ensp
ENSRNOP00000083232
resolver
ensp
ENSRNOP00000090577
resolver
enst
ENSRNOT00000099961
resolver
enst
ENSRNOT00000111888
resolver
genesymbol
Ets1
resolver
genesymbol_syn
Ets-1
resolver
uniprot
A0A8I5ZWK1
resolver
uniprot
A0A8I6AEK6
resolver
uniprot
Q3T1H1
resolver
uniprot_entry
A0A8I5ZWK1_RAT
resolver
uniprot_entry
A0A8I6AEK6_RAT
resolver
uniprot_entry
ETS1_RAT
resolver
uniprot_sec
Q3T1H1
resolver
activity_regulation
ACTIVITY REGULATION: Autoinhibited by a module composed of four alpha helices (HI-1, HI-2, H4, and H5) that flank the DNA-binding ETS domain, reducing the affinity for DNA. Phosphorylation by CaMK2/CaMKII in response to calcium signaling decreases affinity for DNA. {ECO:0000250|UniProtKB:P27577}.
uniprot
proteins
amino_acid_sequence
MKAAVDLKPTLTIIKTEKVDLELFPSPDMECADVPLLTPSSKEMMSQALKATFSGFTKEQQRLGIPKDPRQWTETHVRDWVMWAVNEFSLKGVDFQKFCMNGAALCALGKECFLELAPDFVGDILWEHLEILQKEDVKPYQVNGVNPTYPESRYTSDYFISYGIEHAQCVPPSEFSEPSFITESYQTLHPISSEELLSLKYENDYPSVILRDPLQTDTLQTDYFAIKQEVLTPDNMCMGRASRGKLGGQDSFESIESYDSCDRLTQSWSSQSSFNSLQRVPSYDSFDSEDYPAALPNHKPKGTFKDYVRDRADLNKDKPVIPAAALAGYTGSGPIQLWQFLLELLTDKSCQSFISWTGDGWEFKLSDPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQSLLGYTPEELHAMLDVKPDADE
uniprot
proteins
function
FUNCTION: Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion. {ECO:0000250|UniProtKB:P14921}.
uniprot
proteins
mass_dalton
50423
uniprot
proteins
post_translational_modification
PTM: Sumoylated on Lys-15 and Lys-227, preferentially with SUMO2; which inhibits transcriptional activity. {ECO:0000250|UniProtKB:P27577}.; PTM: Ubiquitinated; which induces proteasomal degradation. {ECO:0000250|UniProtKB:P27577}.; PTM: Phosphorylation at Ser-251, Ser-282 and Ser-285 by CaMK2/CaMKII in response to calcium signaling decreases affinity for DNA: an increasing number of phosphoserines causes DNA-binding to become progressively weaker. {ECO:0000250|UniProtKB:P27577}.
uniprot
proteins
protein_family
ETS family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8139017
uniprot
proteins
sequence_length
441
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P14921}. Cytoplasm {ECO:0000250|UniProtKB:P14921}.
uniprot
proteins