Akap7
entrez
432442
canonical
uniprot
O55074
canonical
uniprot
Q7TN79
canonical
ensembl
ENSMUSG00000039166
resolver
ensp
ENSMUSP00000043624
resolver
ensp
ENSMUSP00000093455
resolver
ensp
ENSMUSP00000097590
resolver
ensp
ENSMUSP00000217834
resolver
ensp
ENSMUSP00000217838
resolver
enst
ENSMUST00000041984
resolver
enst
ENSMUST00000095779
resolver
enst
ENSMUST00000100012
resolver
genesymbol
Akap7
resolver
genesymbol_syn
Akap18
resolver
uniprot
F7CQ62
resolver
uniprot
F8VQ58
resolver
uniprot
G3X9Q5
resolver
uniprot
Q4KL21
resolver
uniprot_entry
AKA7A_MOUSE
resolver
uniprot_entry
AKA7G_MOUSE
resolver
uniprot_entry
F7CQ62_MOUSE
resolver
uniprot_entry
Q4KL21_MOUSE
resolver
uniprot_sec
F8VQ58
resolver
uniprot_sec
G3X9Q5
resolver
amino_acid_sequence
MGQLCCFPFARDEGKICEKDRREPEDAELVRLSKRLVENAVLKAVQQYLEETQNKKQPGEGNSTKAEEGDRNGDGSDNNRK
uniprot
proteins
amino_acid_sequence
MPFAAVDIQDDCGSPDVPQANPKRSKEEEEDRGDKNDHVKKRKKAKKDYQPNYFLSIPITNKKITTGIKVLQNSILQQDKRLTKAMVGDGSFHITLLVMQLLNEDEVNIGTDALLELKPFVEEILEGKHLALPFQGIGTFQGQVGFVKLADGDHVSALLEIAETAKRTFREKGILAGESRTFKPHLTFMKLSKAPMLRKKGVRKIEPGLYEQFIDHRFGEELLYQIDLCSMLKKKQSNGYYHCESSIVIGEKDRREPEDAELVRLSKRLVENAVLKAVQQYLEETQNKKQPGEGNSTKAEEGDRNGDGSDNNRK
uniprot
proteins
function
FUNCTION: Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium (By similarity). {ECO:0000250|UniProtKB:Q9P0M2, ECO:0000305}.
uniprot
proteins
function
FUNCTION: Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium (By similarity). {ECO:0000250, ECO:0000269|PubMed:9620705}.
uniprot
proteins
mass_dalton
35482
uniprot
proteins
mass_dalton
9169
uniprot
proteins
mutagenesis
MUTAGEN 41; /note="K->E: Abolishes nuclear localization; when associated with E-43."; /evidence="ECO:0000269|PubMed:12804576"; MUTAGEN 43; /note="K->E: Abolishes nuclear localization; when associated with E-41."; /evidence="ECO:0000269|PubMed:12804576"; MUTAGEN 265; /note="L->P: Abolishes PKA-RI-alpha binding; when associated with P-269."; /evidence="ECO:0000269|PubMed:12804576"; MUTAGEN 269; /note="L->P: Abolishes PKA-RI-alpha binding; when associated with P-265."; /evidence="ECO:0000269|PubMed:12804576
uniprot
proteins
pubmed
12804576
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9545239
uniprot
proteins
pubmed
9620705
uniprot
proteins
sequence_length
314
uniprot
proteins
sequence_length
81
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lateral cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000269|PubMed:9545239}.
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12804576}. Cytoplasm {ECO:0000269|PubMed:12804576}. Note=In oocytes, localizes to the nucleus, to germinal vesicles and throughout the cytoplasm. {ECO:0000269|PubMed:12804576}.
uniprot
proteins