Sf3b4
entrez
295270
canonical
uniprot
Q6AYL5
canonical
ensembl
ENSRNOG00000021181
resolver
ensembl
ENSRNOG00055032295
resolver
ensembl
ENSRNOG00060013946
resolver
ensembl
ENSRNOG00065030977
resolver
ensp
ENSRNOP00000028758
resolver
ensp
ENSRNOP00055045943
resolver
ensp
ENSRNOP00060018971
resolver
ensp
ENSRNOP00065043898
resolver
enst
ENSRNOT00000028758
resolver
enst
ENSRNOT00055055760
resolver
enst
ENSRNOT00060023844
resolver
enst
ENSRNOT00065053409
resolver
genesymbol
Sf3b4
resolver
uniprot_entry
SF3B4_RAT
resolver
amino_acid_sequence
MAAGPISERNQDATVYVGGLDEKVSEPLLWELFLQAGPVVNTHMPKDRVTGQHQGYGFVEFLSEEDADYAIKIMNMIKLYGKPIRVNKASAHNKNLDVGANIFIGNLDPEIDEKLLYDTFSAFGVILQTPKIMRDPDTGNSKGYAFINFASFDASDAAIEAMNGQYLCNRPITVSYAFKKDSKGERHGSAAERLLAAQNPLSQADRPHQLFADAPPPPSAPNPVVSSLGSGLPPPGMPPPGSFPPPVPPPGALPPGIPPAMPPPPMPPGAGGHGPPAAGTPGAGHPGHGHSHPHPFPPGGMPHPGMSQMQLAHHGPHGLGHPHAGPPGSGGQPPPRPPPGMPHPGPPPMGMPPRGPPFGSPMGHPGPMPPHGMRGPPPLMPPHGYTGPPRPPPYGYQRGPLPPPRPTPRPPVPPRGPLRGPLPQ
uniprot
proteins
function
FUNCTION: Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3B4 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA. Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs. {ECO:0000250|UniProtKB:Q15427}.
uniprot
proteins
mass_dalton
44356
uniprot
proteins
protein_family
SF3B4 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
424
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q15427}.
uniprot
proteins