SRSF7
entrez
6432
canonical
uniprot
Q16629
canonical
ensembl
ENSG00000115875
resolver
ensp
ENSP00000325905
resolver
ensp
ENSP00000386806
resolver
ensp
ENSP00000402264
resolver
ensp
ENSP00000579019
resolver
enst
ENST00000409276
resolver
genesymbol
SRSF7
resolver
genesymbol_syn
SFRS7
resolver
hgnc
HGNC:10789
resolver
uniprot
B4DLU6
resolver
uniprot
C9JAB2
resolver
uniprot
G5E9M3
resolver
uniprot
Q564D3
resolver
uniprot_entry
C9JAB2_HUMAN
resolver
uniprot_entry
SRSF7_HUMAN
resolver
uniprot_sec
B4DLU6
resolver
uniprot_sec
G5E9M3
resolver
uniprot_sec
Q564D3
resolver
amino_acid_sequence
MSRYGRYGGETKVYVGNLGTGAGKGELERAFSYYGPLRTVWIARNPPGFAFVEFEDPRDAEDAVRGLDGKVICGSRVRVELSTGMPRRSRFDRPPARRPFDPNDRCYECGEKGHYAYDCHRYSRRRRSRSRSRSHSRSRGRRYSRSRSRSRGRRSRSASPRRSRSISLRRSRSASLRRSRSGSIKGSRYFQSPSRSRSRSRSISRPRSSRSKSRSPSPKRSRSPSGSPRRSASPERMD
uniprot
proteins
function
FUNCTION: Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific. {ECO:0000269|PubMed:11336712, ECO:0000269|PubMed:12667464, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:18364396}.
uniprot
proteins
mass_dalton
27367
uniprot
proteins
mutagenesis
MUTAGEN 87..88; /note="RR->EE: Abolishes interaction with NXF1."; /evidence="ECO:0000269|PubMed:17036044"; MUTAGEN 97..98; /note="RR->EE: Abolishes interaction with NXF1."; /evidence="ECO:0000269|PubMed:17036044
uniprot
proteins
post_translational_modification
PTM: Extensively phosphorylated on serine residues in the RS domain. {ECO:0000305}.
uniprot
proteins
protein_family
Splicing factor SR family
uniprot
proteins
pubmed
11336712
uniprot
proteins
pubmed
12501247
uniprot
proteins
pubmed
12667464
uniprot
proteins
pubmed
14684736
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15009664
uniprot
proteins
pubmed
15169763
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17036044
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18364396
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20857263
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
34237909
uniprot
proteins
pubmed
7629084
uniprot
proteins
pubmed
8013463
uniprot
proteins
sequence_length
238
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11336712}. Cytoplasm {ECO:0000269|PubMed:11336712}.
uniprot
proteins