ASB9
entrez
140462
canonical
uniprot
Q96DX5
canonical
ensembl
ENSG00000102048
resolver
ensp
ENSP00000369850
resolver
ensp
ENSP00000369852
resolver
ensp
ENSP00000369855
resolver
ensp
ENSP00000438943
resolver
ensp
ENSP00000574669
resolver
genesymbol
ASB9
resolver
hgnc
HGNC:17184
resolver
uniprot
A0A024RBW7
resolver
uniprot
A8K8A5
resolver
uniprot
Q9BVF5
resolver
uniprot
Q9NWS5
resolver
uniprot
Q9Y4T3
resolver
uniprot_entry
A0A024RBW7_HUMAN
resolver
uniprot_entry
ASB9_HUMAN
resolver
uniprot_sec
A8K8A5
resolver
uniprot_sec
Q9BVF5
resolver
uniprot_sec
Q9NWS5
resolver
uniprot_sec
Q9Y4T3
resolver
amino_acid_sequence
MDGKQGGMDGSKPAGPRDFPGIRLLSNPLMGDAVSDWSPMHEAAIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVELVPPESPLAQLFLEREGPPSLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLHL
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:25654263, PubMed:33268465). The ECS(ASB9) complex catalyzes ubiquitination of creatine kinases CKB and CKMT1A (PubMed:20302626, PubMed:22418839, PubMed:25654263, PubMed:33268465). {ECO:0000269|PubMed:20302626, ECO:0000269|PubMed:22418839, ECO:0000269|PubMed:25654263, ECO:0000269|PubMed:33268465}.; FUNCTION: [Isoform 2]: Does not interact with the Elongin BC complex, likely to be a negative regulator of isoform 1. {ECO:0000269|PubMed:20302626}.
uniprot
proteins
mass_dalton
31858
uniprot
proteins
mutagenesis
MUTAGEN 32; /note="D->A: Decreased ability to mediate ubiquitination of CKB."; /evidence="ECO:0000269|PubMed:25654263
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:25654263, ECO:0000269|PubMed:33268465}.
uniprot
proteins
protein_family
Ankyrin SOCS box (ASB) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
20302626
uniprot
proteins
pubmed
22418839
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23837592
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25654263
uniprot
proteins
pubmed
32513959
uniprot
proteins
pubmed
33268465
uniprot
proteins
sequence_length
294
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:20302626}.
uniprot
proteins