POLA2
entrez
23649
canonical
uniprot
Q14181
canonical
ensembl
ENSG00000014138
resolver
ensp
ENSP00000265465
resolver
ensp
ENSP00000434173
resolver
ensp
ENSP00000516439
resolver
ensp
ENSP00000516440
resolver
ensp
ENSP00000796757
resolver
enst
ENST00000525924
resolver
enst
ENST00000706537
resolver
enst
ENST00000706538
resolver
genesymbol
POLA2
resolver
hgnc
HGNC:30073
resolver
uniprot
A0A9L9PY44
resolver
uniprot
B4DNB4
resolver
uniprot
H0YDR7
resolver
uniprot
Q9BPV3
resolver
uniprot_entry
A0A9L9PY44_HUMAN
resolver
uniprot_entry
DPOA2_HUMAN
resolver
uniprot_entry
H0YDR7_HUMAN
resolver
uniprot_sec
B4DNB4
resolver
uniprot_sec
Q9BPV3
resolver
amino_acid_sequence
MSASAQQLAEELQIFGLDCEEALIEKLVELCVQYGQNEEGMVGELIAFCTSTHKVGLTSEILNSFEHEFLSKRLSKARHSTCKDSGHAGARDIVSIQELIEVEEEEEILLNSYTTPSKGSQKRAISTPETPLTKRSVSTRSPHQLLSPSSFSPSATPSQKYNSRSNRGEVVTSFGLAQGVSWSGRGGAGNISLKVLGCPEALTGSYKSMFQKLPDIREVLTCKIEELGSELKEHYKIEAFTPLLAPAQEPVTLLGQIGCDSNGKLNNKSVILEGDREHSSGAQIPVDLSELKEYSLFPGQVVIMEGINTTGRKLVATKLYEGVPLPFYQPTEEDADFEQSMVLVACGPYTTSDSITYDPLLDLIAVINHDRPDVCILFGPFLDAKHEQVENCLLTSPFEDIFKQCLRTIIEGTRSSGSHLVFVPSLRDVHHEPVYPQPPFSYSDLSREDKKQVQFVSEPCSLSINGVIFGLTSTDLLFHLGAEEISSSSGTSDRFSRILKHILTQRSYYPLYPPQEDMAIDYESFYVYAQLPVTPDVLIIPSELRYFVKDVLGCVCVNPGRLTKGQVGGTFARLYLRRPAADGAERQSPCIAVQVVRI
uniprot
proteins
function
FUNCTION: Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis (PubMed:9705292). During the S phase of the cell cycle, the DNA polymerase alpha complex (composed of a catalytic subunit POLA1, an accessory subunit POLA2 and two primase subunits, the catalytic subunit PRIM1 and the regulatory subunit PRIM2) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1 (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerizing short RNA primers on both leading and lagging strands (By similarity). These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand, respectively (By similarity). {ECO:0000250|UniProtKB:P09884, ECO:0000250|UniProtKB:P20664, ECO:0000269|PubMed:9705292}.
uniprot
proteins
mass_dalton
65948
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in a cell cycle-dependent manner, in G2/M phase. {ECO:0000269|PubMed:1902230}.
uniprot
proteins
protein_family
DNA polymerase alpha subunit B family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
1902230
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26975377
uniprot
proteins
pubmed
8223465
uniprot
proteins
pubmed
9705292
uniprot
proteins
sequence_length
598
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins