Fbxo24
entrez
71176
canonical
uniprot
Q9D417
canonical
ensembl
ENSMUSG00000089984
resolver
ensp
ENSMUSP00000031732
resolver
enst
ENSMUST00000031732
resolver
genesymbol
Fbxo24
resolver
genesymbol_syn
Fbx24
resolver
uniprot_entry
FBX24_MOUSE
resolver
amino_acid_sequence
MVKRSCPSCGLEAGSEKKERGNPISVQLFPPELVEHIVSFLPVKDLVALGQTCHYFHEVCDAEGVWRRICRRLSPRIRDQSSGARPWKRAAILNYTKGLYFQAFGGRRRCLSKSVAPMLAHGYRRFLPTKDHVFILDYVGTLFFLKNALVSSTLGQIQWKRACRYVVLCRGAKDFASDPRCDTVYRKYLYVLATREQPAVVGTTGSRACDCVEVYLQSSGQRVFKMTFHHSMSFKQIVLVGQETQRALLLLTEEGKIYSLVVNETQLDQPRSYTVQLALRKVSRCLPHLRVTCMASNQSSTLYITGGTLIPRKQVPKAAELRAPDPPDQGGVYFEVHTPGVYRDLFGTLQAFDPLDHQMPLALSLPAKVLFCALGYNHLGLVDEFGRIFMQGNNRYGQLGTGDKMDRGEPTQVHYLQRPIALWCGLNHSLVLSQTSDFSKELLGCGCGAGGRLPGWPKGSASFVKLHIKVPLCACSLCSTRECLYMLSSHDIEQCPVYRDLPASRVGGSPEPSQGAGAPQDPGGTAQACEEYLSQIHSCPTLQDRMEKMKEIVGWMPLMAAQKDFFWEALDMLQRAAGGAGPDTSTPES
uniprot
proteins
function
FUNCTION: Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Specifically recognizes the deacetylated form of nucleoside diphosphate kinase A/NME1 and targets it for ubiquitin-mediated degradation. Functions as a key regulator of cell proliferation by targeting PRMT6 for ubiquitination and proteasomal degradation, leading to cell cycle inhibition (By similarity). Also mediates 'Lys-6'-linked polyubiquitination of the mitochondrial S-adenosylmethionine transporter SLC25A26, targeting it for degradation and thereby maintaining mitochondrial function during spermiogenesis (PubMed:40657752). Promotes ubiquitination and degradation of mitochondrial aspartyl-tRNA synthetase DARS2, contributing to immunosuppressive activity (PubMed:39039092). In the nucleus, targets FOXK2 for ubiquitin-mediated degradation, a process that critically modulates mitochondrial respiration and cellular bioenergetics in lung epithelial cells (By similarity). {ECO:0000250|UniProtKB:O75426, ECO:0000269|PubMed:39039092, ECO:0000269|PubMed:40657752}.
uniprot
proteins
mass_dalton
65429
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
39039092
uniprot
proteins
pubmed
40657752
uniprot
proteins
sequence_length
589
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:O75426}. Nucleus {ECO:0000250|UniProtKB:O75426}.
uniprot
proteins