SNX18
entrez
112574
canonical
uniprot
Q96RF0
canonical
ensembl
ENSG00000178996
resolver
ensp
ENSP00000317332
resolver
ensp
ENSP00000342276
resolver
ensp
ENSP00000370817
resolver
ensp
ENSP00000522169
resolver
genesymbol
SNX18
resolver
genesymbol_syn
SH3PXD3B
resolver
hgnc
HGNC:19245
resolver
uniprot
B4E2B3
resolver
uniprot
H7BXX3
resolver
uniprot
Q05BB3
resolver
uniprot
Q0VG02
resolver
uniprot_entry
SNX18_HUMAN
resolver
uniprot_sec
B4E2B3
resolver
uniprot_sec
H7BXX3
resolver
uniprot_sec
Q05BB3
resolver
uniprot_sec
Q0VG02
resolver
amino_acid_sequence
MALRARALYDFRSENPGEISLREHEVLSLCSEQDIEGWLEGVNSRGDRGLFPASYVQVIRAPEPGPAGDGGPGAPARYANVPPGGFEPLPVAPPASFKPPPDAFQALLQPQQAPPPSTFQPPGAGFPYGGGALQPSPQQLYGGYQASQGSDDDWDDEWDDSSTVADEPGALGSGAYPDLDGSSSAGVGAAGRYRLSTRSDLSLGSRGGSVPPQHHPSGPKSSATVSRNLNRFSTFVKSGGEAFVLGEASGFVKDGDKLCVVLGPYGPEWQENPYPFQCTIDDPTKQTKFKGMKSYISYKLVPTHTQVPVHRRYKHFDWLYARLAEKFPVISVPHLPEKQATGRFEEDFISKRRKGLIWWMNHMASHPVLAQCDVFQHFLTCPSSTDEKAWKQGKRKAEKDEMVGANFFLTLSTPPAAALDLQEVESKIDGFKCFTKKMDDSALQLNHTANEFARKQVTGFKKEYQKVGQSFRGLSQAFELDQQAFSVGLNQAIAFTGDAYDAIGELFAEQPRQDLDPVMDLLALYQGHLANFPDIIHVQKGKAWPLEQVIWSVLCRLKGATLTAVPLWVSESYSTGEEASRDVDAWVFSLECKLDCSTGSFLLEYLALGNEYSFSKVQRVPLMTVLSF
uniprot
proteins
function
FUNCTION: Involved in endocytosis and intracellular vesicle trafficking, both during interphase and at the end of mitosis (PubMed:18411244, PubMed:20427313, PubMed:21048941, PubMed:22718350). Required for efficient progress through mitosis and cytokinesis (PubMed:22718350). Required for normal formation of the cleavage furrow at the end of mitosis (PubMed:22718350). Plays a role in endocytosis via clathrin-coated pits, but also clathrin-independent, actin-dependent fluid-phase endocytosis (PubMed:20427313). Plays a role in macropinocytosis (PubMed:21048941). Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate and promotes membrane tubulation (PubMed:18411244). Stimulates the GTPase activity of DNM2 (PubMed:20427313). Promotes DNM2 location at the plasma membrane (PubMed:20427313). Together with DNM2, involved in autophagosome assembly by regulating trafficking from recycling endosomes of phospholipid scramblase ATG9A (PubMed:29437695). {ECO:0000269|PubMed:18411244, ECO:0000269|PubMed:20427313, ECO:0000269|PubMed:21048941, ECO:0000269|PubMed:22718350, ECO:0000269|PubMed:29437695}.
uniprot
proteins
mass_dalton
68894
uniprot
proteins
protein_family
Sorting nexin family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18411244
uniprot
proteins
pubmed
20427313
uniprot
proteins
pubmed
20491914
uniprot
proteins
pubmed
21048941
uniprot
proteins
pubmed
22718350
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29437695
uniprot
proteins
sequence_length
628
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endomembrane system {ECO:0000269|PubMed:22718350}; Peripheral membrane protein {ECO:0000269|PubMed:18411244}; Cytoplasmic side {ECO:0000269|PubMed:18411244}. Endosome membrane {ECO:0000269|PubMed:29437695}; Peripheral membrane protein {ECO:0000269|PubMed:18411244}; Cytoplasmic side {ECO:0000269|PubMed:18411244}. Recycling endosome membrane {ECO:0000269|PubMed:29437695}; Peripheral membrane protein {ECO:0000269|PubMed:18411244}; Cytoplasmic side {ECO:0000269|PubMed:18411244}. Cell membrane {ECO:0000269|PubMed:20427313}; Peripheral membrane protein {ECO:0000269|PubMed:18411244}; Cytoplasmic side {ECO:0000269|PubMed:18411244}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:18411244}; Peripheral membrane protein {ECO:0000269|PubMed:18411244}; Cytoplasmic side {ECO:0000269|PubMed:18411244}. Note=Localized at sites of endocytosis at the cell membrane (PubMed:18411244). Detected on newly formed macropinosomes (PubMed:21048941). Partially colocalized with clathrin and dynamin at the cell membrane (PubMed:20427313). Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation (PubMed:18411244). {ECO:0000269|PubMed:18411244, ECO:0000269|PubMed:20427313, ECO:0000269|PubMed:21048941}.
uniprot
proteins