Tollip
entrez
54473
canonical
uniprot
Q9QZ06
canonical
ensembl
ENSMUSG00000025139
resolver
ensp
ENSMUSP00000001950
resolver
ensp
ENSMUSP00000117938
resolver
enst
ENSMUST00000001950
resolver
enst
ENSMUST00000130439
resolver
genesymbol
Tollip
resolver
uniprot
F7AT44
resolver
uniprot
Q543N1
resolver
uniprot
Q9D5P5
resolver
uniprot_entry
F7AT44_MOUSE
resolver
uniprot_entry
TOLIP_MOUSE
resolver
uniprot_sec
Q543N1
resolver
uniprot_sec
Q9D5P5
resolver
amino_acid_sequence
MATTVSTQRGPVYIGELPQDFLRITPTQQQQQIQLDAQAAQQLQYGGTVGTVGRLSITVVQAKLAKNYGMTRMDPYCRLRLGYAVYETPTAHNGAKNPRWNKVIQCTVPPGVDSFYLEIFDERAFSMDDRIAWTHITIPESLKQGQVEDEWYSLSGRQGDDKEGMINLVMSYTSLPAAMMMPPQPVVLMPTVYQQGVGYVPIAGMPAVCSPGMVPMAMPPPAVAPQPRCNEEDLKAIQDMFPNMDREVIRSVLEAQRGNKDAAINSLLQMGEES
uniprot
proteins
function
FUNCTION: Component of the signaling pathway of IL-1 and Toll-like receptors (By similarity). Inhibits cell activation by microbial products (By similarity). Recruits IRAK1 to the IL-1 receptor complex (By similarity). Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates (By similarity). The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity). In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes (By similarity). Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P) (By similarity). {ECO:0000250|UniProtKB:Q9H0E2}.
uniprot
proteins
mass_dalton
30345
uniprot
proteins
protein_family
Tollip family
uniprot
proteins
pubmed
10854325
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
274
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H0E2}. Endosome {ECO:0000250|UniProtKB:Q9H0E2}. Early endosome {ECO:0000250|UniProtKB:Q9H0E2}. Note=Localized to endo/exosomal vesicles. {ECO:0000250|UniProtKB:Q9H0E2}.
uniprot
proteins