BRSK1
entrez
84446
canonical
uniprot
Q8TDC3
canonical
ensembl
ENSG00000160469
resolver
ensp
ENSP00000310649
resolver
genesymbol
BRSK1
resolver
genesymbol_syn
KIAA1811
resolver
genesymbol_syn
SAD1
resolver
genesymbol_syn
SADB
resolver
hgnc
HGNC:18994
resolver
uniprot
F1DG44
resolver
uniprot
Q5J5B5
resolver
uniprot
Q8NDD0
resolver
uniprot
Q8NDR4
resolver
uniprot
Q8TDC2
resolver
uniprot
Q96AV4
resolver
uniprot
Q96JL4
resolver
uniprot_entry
BRSK1_HUMAN
resolver
uniprot_sec
F1DG44
resolver
uniprot_sec
Q5J5B5
resolver
uniprot_sec
Q8NDD0
resolver
uniprot_sec
Q8NDR4
resolver
uniprot_sec
Q8TDC2
resolver
uniprot_sec
Q96AV4
resolver
uniprot_sec
Q96JL4
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation on Thr-189 by STK11/LKB1. {ECO:0000269|PubMed:14976552}.
uniprot
proteins
amino_acid_sequence
MSSGAKEGGGGSPAYHLPHPHPHPPQHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKVAIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFDYLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASLQVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLLEKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLEPAPGRRVAMRSLPSNGELDPDVLESMASLGCFRDRERLHRELRSEEENQEKMIYYLLLDRKERYPSCEDQDLPPRNDVDPPRKRVDSPMLSRHGKRRPERKSMEVLSITDAGGGGSPVPTRRALEMAQHSQRSRSVSGASTGLSSSPLSSPRSPVFSFSPEPGAGDEARGGGSPTSKTQTLPSRGPRGGGAGEQPPPPSARSTPLPGPPGSPRSSGGTPLHSPLHTPRASPTGTPGTTPPPSPGGGVGGAAWRSRLNSIRNSFLGSPRFHRRKMQVPTAEEMSSLTPESSPELAKRSWFGNFISLDKEEQIFLVLKDKPLSSIKADIVHAFLSIPSLSHSVLSQTSFRAEYKASGGPSVFQKPVRFQVDISSSEGPEPSPRRDGSGGGGIYSVTFTLISGPSRRFKRVVETIQAQLLSTHDQPSVQALADEKNGAQTRPAGAPPRSLQPPPGRPDPELSSSPRRGPPKDKKLLATNGTPLP
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
ec_number
2.7.11.26
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C. {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15150265, ECO:0000269|PubMed:20026642, ECO:0000269|PubMed:21985311}.
uniprot
proteins
mass_dalton
85087
uniprot
proteins
mutagenesis
MUTAGEN 59; /note="K->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:15150265"; MUTAGEN 189; /note="T->A: Prevents phosphorylation and activation by STK11/LKB1 complex."; /evidence="ECO:0000269|PubMed:14976552"; MUTAGEN 327; /note="G->A: Abolishes activation of kinase activity."; /evidence="ECO:0000269|PubMed:18339622
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Thr-189 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Not phosphorylated at Thr-189 by CaMKK2. In contrast, it is phosphorylated and activated by CaMKK1. May be inactivated via dephosphorylation of Thr-189 by PP2C. {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:18339622, ECO:0000269|PubMed:19958286}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
SNF1 subfamily
uniprot
proteins
pubmed
11347906
uniprot
proteins
pubmed
14976552
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15150265
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16630837
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18339622
uniprot
proteins
pubmed
19648910
uniprot
proteins
pubmed
19958286
uniprot
proteins
pubmed
20026642
uniprot
proteins
pubmed
21985311
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
778
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15150265}. Nucleus {ECO:0000269|PubMed:15150265}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Synapse {ECO:0000250|UniProtKB:B2DD29}. Presynaptic active zone {ECO:0000250|UniProtKB:B2DD29}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250|UniProtKB:B2DD29}. Note=Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS-induced DNA damage (By similarity). {ECO:0000250}.
uniprot
proteins