CXCL10
entrez
3627
canonical
uniprot
P02778
canonical
ensembl
ENSG00000169245
resolver
ensp
ENSP00000305651
resolver
enst
ENST00000306602
resolver
genesymbol
CXCL10
resolver
genesymbol_syn
INP10
resolver
genesymbol_syn
SCYB10
resolver
hgnc
HGNC:10637
resolver
uniprot
Q96QJ5
resolver
uniprot_entry
CXL10_HUMAN
resolver
uniprot_sec
Q96QJ5
resolver
amino_acid_sequence
MNQTAILICCLIFLTLSGIQGVPLSRTVRCTCISISNQPVNPRSLEKLEIIPASQFCPRVEIIATMKKKGEKRCLNPESKAIKNLLKAVSKERSKRSP
uniprot
proteins
function
FUNCTION: Pro-inflammatory cytokine that is involved in a wide variety of processes such as chemotaxis, differentiation, and activation of peripheral immune cells, regulation of cell growth, apoptosis and modulation of angiostatic effects (PubMed:11157474, PubMed:22652417, PubMed:7540647). Plays thereby an important role during viral infections by stimulating the activation and migration of immune cells to the infected sites (By similarity). Mechanistically, binding of CXCL10 to the CXCR3 receptor activates G protein-mediated signaling and results in downstream activation of phospholipase C-dependent pathway, an increase in intracellular calcium production and actin reorganization (PubMed:12750173, PubMed:19151743). In turn, recruitment of activated Th1 lymphocytes occurs at sites of inflammation (PubMed:12663757, PubMed:12750173). Activation of the CXCL10/CXCR3 axis also plays an important role in neurons in response to brain injury for activating microglia, the resident macrophage population of the central nervous system, and directing them to the lesion site. This recruitment is an essential element for neuronal reorganization (By similarity). {ECO:0000250|UniProtKB:P17515, ECO:0000269|PubMed:11157474, ECO:0000269|PubMed:12663757, ECO:0000269|PubMed:12750173, ECO:0000269|PubMed:19151743, ECO:0000269|PubMed:22652417, ECO:0000269|PubMed:7540647}.
uniprot
proteins
mass_dalton
10881
uniprot
proteins
post_translational_modification
PTM: Several proteases can mediate post-secretion cleavages. DPP4 cleaves CXCL10 on its N-terminal 2 amino acids leading to an antagonist form of CXCL10. This dominant negative form is capable of binding CXCR3 but does not induce signaling. MMP9 cleaves 9 amino acids instead. {ECO:0000269|PubMed:21183794}.
uniprot
proteins
protein_family
Intercrine alpha (chemokine CxC) family
uniprot
proteins
pubmed
10233762
uniprot
proteins
pubmed
11157474
uniprot
proteins
pubmed
11559369
uniprot
proteins
pubmed
12173928
uniprot
proteins
pubmed
12663757
uniprot
proteins
pubmed
12737818
uniprot
proteins
pubmed
12750173
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18645041
uniprot
proteins
pubmed
19151743
uniprot
proteins
pubmed
21183794
uniprot
proteins
pubmed
22652417
uniprot
proteins
pubmed
3925348
uniprot
proteins
pubmed
7540647
uniprot
proteins
pubmed
8423327
uniprot
proteins
pubmed
9064356
uniprot
proteins
sequence_length
98
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21183794}.
uniprot
proteins