APOC1
entrez
341
canonical
uniprot
P02654
canonical
ensembl
ENSG00000130208
resolver
ensp
ENSP00000465356
resolver
ensp
ENSP00000467368
resolver
ensp
ENSP00000468029
resolver
ensp
ENSP00000468276
resolver
ensp
ENSP00000546468
resolver
ensp
ENSP00000546469
resolver
ensp
ENSP00000598373
resolver
enst
ENST00000588750
resolver
enst
ENST00000588802
resolver
enst
ENST00000592535
resolver
enst
ENST00000592885
resolver
enst
ENST00000876409
resolver
enst
ENST00000876410
resolver
enst
ENST00000928314
resolver
genesymbol
APOC1
resolver
hgnc
HGNC:607
resolver
uniprot
B2R526
resolver
uniprot
K7EPF9
resolver
uniprot
Q6IB97
resolver
uniprot_entry
APOC1_HUMAN
resolver
uniprot_entry
K7EPF9_HUMAN
resolver
uniprot_sec
B2R526
resolver
uniprot_sec
Q6IB97
resolver
amino_acid_sequence
MRLFLSLPVLVVVLSIVLEGPAPAQGTPDVSSALDKLKEFGNTLEDKARELISRIKQSELSAKMREWFSETFQKVKEKLKIDS
uniprot
proteins
function
FUNCTION: Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein. {ECO:0000269|PubMed:17339654, ECO:0000303|PubMed:25160599}.
uniprot
proteins
mass_dalton
9332
uniprot
proteins
protein_family
Apolipoprotein C1 family
uniprot
proteins
pubmed
10391210
uniprot
proteins
pubmed
10520737
uniprot
proteins
pubmed
10545169
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
166984
uniprot
proteins
pubmed
16981907
uniprot
proteins
pubmed
17339654
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25160599
uniprot
proteins
pubmed
2835369
uniprot
proteins
pubmed
28757862
uniprot
proteins
pubmed
2897845
uniprot
proteins
pubmed
2985493
uniprot
proteins
pubmed
4369340
uniprot
proteins
pubmed
6328444
uniprot
proteins
pubmed
7779782
uniprot
proteins
pubmed
9300485
uniprot
proteins
sequence_length
83
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000303|PubMed:2835369}.
uniprot
proteins