Thg1l
entrez
303067
canonical
uniprot
Q5M965
canonical
ensembl
ENSRNOG00000005539
resolver
ensembl
ENSRNOG00055018247
resolver
ensembl
ENSRNOG00060020188
resolver
ensembl
ENSRNOG00065001317
resolver
ensp
ENSRNOP00000007917
resolver
ensp
ENSRNOP00000078306
resolver
ensp
ENSRNOP00055024906
resolver
ensp
ENSRNOP00060028760
resolver
ensp
ENSRNOP00065001199
resolver
enst
ENSRNOT00055030921
resolver
enst
ENSRNOT00060035007
resolver
enst
ENSRNOT00065001738
resolver
genesymbol
Thg1l
resolver
uniprot_entry
THG1_RAT
resolver
amino_acid_sequence
MWAFSTARIGSPLAATSVTLRRCLRLGVAMAKSKFEYVRDFEVDDTCLPHCWVVVRLDGRNFHRFAEKHNFAKPNDSRALHLMTKCAQTVMQELEDIVIAYGQSDEYSFVFRKRSNWFKRRASKFMTLVASQFASSYVFYWRDYFEDQPLLYPPGFDGRVVLYPSNQTLKDYLSWRQADCHINNLYNTVFWALIQQSGLTPVQAQQRLKGTLTADKNEILFSEFHINYNNEPHMYRKGTVLVWQKVNEVRTQEIRLPAEMEGEKMAVTRTRTKLVALNCDLIGDAFWKEHPEILEGED
uniprot
proteins
ec_number
2.7.7.79
uniprot
proteins
function
FUNCTION: Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis. Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion. By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress. {ECO:0000250|UniProtKB:Q9NWX6}.
uniprot
proteins
mass_dalton
34850
uniprot
proteins
protein_family
TRNA(His) guanylyltransferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
298
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Mitochondrion {ECO:0000250|UniProtKB:Q9NWX6}.
uniprot
proteins