AOC3
entrez
8639
canonical
uniprot
Q16853
canonical
ensembl
ENSG00000131471
resolver
ensp
ENSP00000312326
resolver
ensp
ENSP00000468632
resolver
ensp
ENSP00000477686
resolver
ensp
ENSP00000484312
resolver
ensp
ENSP00000644974
resolver
genesymbol
AOC3
resolver
genesymbol_syn
VAP1
resolver
hgnc
HGNC:550
resolver
uniprot
B2RCI5
resolver
uniprot
K7ESB3
resolver
uniprot
L0L8N9
resolver
uniprot
Q45F94
resolver
uniprot
Q9UEU7
resolver
uniprot_entry
AOC3_HUMAN
resolver
uniprot_entry
Q9UEU7_HUMAN
resolver
uniprot_sec
B2RCI5
resolver
uniprot_sec
K7ESB3
resolver
uniprot_sec
L0L8N9
resolver
uniprot_sec
Q45F94
resolver
amino_acid_sequence
MNQKTILVLLILAVITIFALVCVLLVGRGGDGGEPSQLPHCPSVSPSAQPWTHPGQSQLFADLSREELTAVMRFLTQRLGPGLVDAAQARPSDNCVFSVELQLPPKAAALAHLDRGSPPPAREALAIVFFGRQPQPNVSELVVGPLPHPSYMRDVTVERHGGPLPYHRRPVLFQEYLDIDQMIFNRELPQASGLLHHCCFYKHRGRNLVTMTTAPRGLQSGDRATWFGLYYNISGAGFFLHHVGLELLVNHKALDPARWTIQKVFYQGRYYDSLAQLEAQFEAGLVNVVLIPDNGTGGSWSLKSPVPPGPAPPLQFYPQGPRFSVQGSRVASSLWTFSFGLGAFSGPRIFDVRFQGERLVYEISLQEALAIYGGNSPAAMTTRYVDGGFGMGKYTTPLTRGVDCPYLATYVDWHFLLESQAPKTIRDAFCVFEQNQGLPLRRHHSDLYSHYFGGLAETVLVVRSMSTLLNYDYVWDTVFHPSGAIEIRFYATGYISSAFLFGATGKYGNQVSEHTLGTVHTHSAHFKVDLDVAGLENWVWAEDMVFVPMAVPWSPEHQLQRLQVTRKLLEMEEQAAFLVGSATPRYLYLASNHSNKWGHPRGYRIQMLSFAGEPLPQNSSMARGFSWERYQLAVTQRKEEEPSSSSVFNQNDPWAPTVDFSDFINNETIAGKDLVAWVTAGFLHIPHAEDIPNTVTVGNGVGFFLRPYNFFDEDPSFYSADSIYFRGDQDAGACEVNPLACLPQAAACAPDLPAFSHGGFSHN
uniprot
proteins
ec_number
1.4.3.21
uniprot
proteins
function
FUNCTION: Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia (PubMed:19588076, PubMed:24304424, PubMed:9653080). Has a preference for the primary monoamines methylamine and benzylamine (PubMed:19588076, PubMed:9653080). Could also act on 2-phenylethylamine but much less efficiently (PubMed:19588076). At endothelial cells surface can also function as a cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion (PubMed:9254657, PubMed:9653080). {ECO:0000269|PubMed:19588076, ECO:0000269|PubMed:24304424, ECO:0000269|PubMed:9254657, ECO:0000269|PubMed:9653080}.; FUNCTION: [Isoform 2]: Has no semicarbazide-sensitive amine oxidase (SSAO) activity. {ECO:0000269|PubMed:23349812}.
uniprot
proteins
mass_dalton
84622
uniprot
proteins
mutagenesis
MUTAGEN 211; /note="M->V: Increased activity towards 2-phenylethylamine, and decreased activity towards methylamine and benzylamine; when associated with N-394 and G-469."; /evidence="ECO:0000269|PubMed:19588076"; MUTAGEN 394; /note="Y->N: Increased activity towards 2-phenylethylamine, and decreased activity towards methylamine and benzylamine; when associated with V-211 and G-469."; /evidence="ECO:0000269|PubMed:19588076"; MUTAGEN 469; /note="L->G: Increased activity towards 2-phenylethylamine, and decreased activity towards methylamine and benzylamine; when associated with V-211 and N-394."; /evidence="ECO:0000269|PubMed:19588076
uniprot
proteins
post_translational_modification
PTM: Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. {ECO:0000269|PubMed:16046623}.; PTM: N- and O-glycosylated. {ECO:0000269|PubMed:16046623, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218}.
uniprot
proteins
protein_family
Copper/topaquinone oxidase family
uniprot
proteins
pubmed
14585497
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15242332
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16046623
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17400359
uniprot
proteins
pubmed
19139490
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19588076
uniprot
proteins
pubmed
23349812
uniprot
proteins
pubmed
24304424
uniprot
proteins
pubmed
8972912
uniprot
proteins
pubmed
9254657
uniprot
proteins
pubmed
9653080
uniprot
proteins
sequence_length
763
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9653080}; Single-pass type II membrane protein {ECO:0000269|PubMed:9653080}.
uniprot
proteins
transmembrane_region
TRANSMEM 6..26; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins