KANK1
entrez
23189
canonical
uniprot
Q14678
canonical
ensembl
ENSG00000107104
resolver
ensp
ENSP00000371730
resolver
ensp
ENSP00000371734
resolver
ensp
ENSP00000371740
resolver
ensp
ENSP00000508451
resolver
ensp
ENSP00000508606
resolver
ensp
ENSP00000508833
resolver
ensp
ENSP00000509034
resolver
ensp
ENSP00000509347
resolver
ensp
ENSP00000509433
resolver
ensp
ENSP00000510058
resolver
ensp
ENSP00000510088
resolver
ensp
ENSP00000510316
resolver
ensp
ENSP00000510515
resolver
ensp
ENSP00000573943
resolver
ensp
ENSP00000573950
resolver
ensp
ENSP00000573952
resolver
ensp
ENSP00000573954
resolver
ensp
ENSP00000573955
resolver
ensp
ENSP00000573956
resolver
ensp
ENSP00000573958
resolver
ensp
ENSP00000573962
resolver
ensp
ENSP00000573963
resolver
ensp
ENSP00000573964
resolver
ensp
ENSP00000573967
resolver
ensp
ENSP00000573968
resolver
ensp
ENSP00000573969
resolver
ensp
ENSP00000587503
resolver
ensp
ENSP00000587504
resolver
ensp
ENSP00000619472
resolver
ensp
ENSP00000619475
resolver
ensp
ENSP00000619478
resolver
ensp
ENSP00000619479
resolver
ensp
ENSP00000619480
resolver
ensp
ENSP00000619481
resolver
ensp
ENSP00000619482
resolver
ensp
ENSP00000619483
resolver
ensp
ENSP00000619485
resolver
ensp
ENSP00000619486
resolver
ensp
ENSP00000619488
resolver
ensp
ENSP00000662030
resolver
ensp
ENSP00000662031
resolver
ensp
ENSP00000662032
resolver
ensp
ENSP00000679863
resolver
enst
ENST00000689926
resolver
enst
ENST00000691319
resolver
enst
ENST00000693021
resolver
enst
ENST00000693143
resolver
enst
ENST00000903897
resolver
enst
ENST00000903899
resolver
enst
ENST00000903903
resolver
enst
ENST00000903904
resolver
enst
ENST00000903905
resolver
enst
ENST00000903908
resolver
enst
ENST00000903909
resolver
enst
ENST00000949413
resolver
enst
ENST00000949416
resolver
enst
ENST00000949419
resolver
enst
ENST00000949420
resolver
enst
ENST00000949421
resolver
enst
ENST00000949422
resolver
enst
ENST00000949423
resolver
enst
ENST00000949424
resolver
enst
ENST00000949426
resolver
enst
ENST00000949427
resolver
enst
ENST00000949429
resolver
genesymbol
KANK1
resolver
genesymbol_syn
ANKRD15
resolver
genesymbol_syn
KANK
resolver
genesymbol_syn
KIAA0172
resolver
hgnc
HGNC:19309
resolver
uniprot
A0A8I5KRP2
resolver
uniprot
A0A8I5KT40
resolver
uniprot
A0A8I5KZ49
resolver
uniprot
A2A2W8
resolver
uniprot
D3DRH3
resolver
uniprot
Q5W0W0
resolver
uniprot
Q8IY65
resolver
uniprot
Q8WX74
resolver
uniprot_entry
A0A8I5KRP2_HUMAN
resolver
uniprot_entry
A0A8I5KT40_HUMAN
resolver
uniprot_entry
A0A8I5KZ49_HUMAN
resolver
uniprot_entry
KANK1_HUMAN
resolver
uniprot_sec
A2A2W8
resolver
uniprot_sec
D3DRH3
resolver
uniprot_sec
Q5W0W0
resolver
uniprot_sec
Q8IY65
resolver
uniprot_sec
Q8WX74
resolver
amino_acid_sequence
MAHTTKVNGSASGKAGDILSGDQDKEQKDPYFVETPYGYQLDLDFLKYVDDIQKGNTIKRLNIQKRRKPSVPCPEPRTTSGQQGIWTSTESLSSSNSDDNKQCPNFLIARSQVTSTPISKPPPPLETSLPFLTIPENRQLPPPSPQLPKHNLHVTKTLMETRRRLEQERATMQMTPGEFRRPRLASFGGMGTTSSLPSFVGSGNHNPAKHQLQNGYQGNGDYGSYAPAAPTTSSMGSSIRHSPLSSGISTPVTNVSPMHLQHIREQMAIALKRLKELEEQVRTIPVLQVKISVLQEEKRQLVSQLKNQRAASQINVCGVRKRSYSAGNASQLEQLSRARRSGGELYIDYEEEEMETVEQSTQRIKEFRQLTADMQALEQKIQDSSCEASSELRENGECRSVAVGAEENMNDIVVYHRGSRSCKDAAVGTLVEMRNCGVSVTEAMLGVMTEADKEIELQQQTIESLKEKIYRLEVQLRETTHDREMTKLKQELQAAGSRKKVDKATMAQPLVFSKVVEAVVQTRDQMVGSHMDLVDTCVGTSVETNSVGISCQPECKNKVVGPELPMNWWIVKERVEMHDRCAGRSVEMCDKSVSVEVSVCETGSNTEESVNDLTLLKTNLNLKEVRSIGCGDCSVDVTVCSPKECASRGVNTEAVSQVEAAVMAVPRTADQDTSTDLEQVHQFTNTETATLIESCTNTCLSTLDKQTSTQTVETRTVAVGEGRVKDINSSTKTRSIGVGTLLSGHSGFDRPSAVKTKESGVGQININDNYLVGLKMRTIACGPPQLTVGLTASRRSVGVGDDPVGESLENPQPQAPLGMMTGLDHYIERIQKLLAEQQTLLAENYSELAEAFGEPHSQMGSLNSQLISTLSSINSVMKSASTEELRNPDFQKTSLGKITGNYLGYTCKCGGLQSGSPLSSQTSQPEQEVGTSEGKPISSLDAFPTQEGTLSPVNLTDDQIAAGLYACTNNESTLKSIMKKKDGNKDSNGAKKNLQFVGINGGYETTSSDDSSSDESSSSESDDECDVIEYPLEEEEEEEDEDTRGMAEGHHAVNIEGLKSARVEDEMQVQECEPEKVEIRERYELSEKMLSACNLLKNTINDPKALTSKDMRFCLNTLQHEWFRVSSQKSAIPAMVGDYIAAFEAISPDVLRYVINLADGNGNTALHYSVSHSNFEIVKLLLDADVCNVDHQNKAGYTPIMLAALAAVEAEKDMRIVEELFGCGDVNAKASQAGQTALMLAVSHGRIDMVKGLLACGADVNIQDDEGSTALMCASEHGHVEIVKLLLAQPGCNGHLEDNDGSTALSIALEAGHKDIAVLLYAHVNFAKAQSPGTPRLGRKTSPGPTHRGSFD
uniprot
proteins
disease_involvement
DISEASE: Cerebral palsy, spastic quadriplegic 2 (CPSQ2) [MIM:612900]: A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals manifest congenital hypotonia evolving over the first year to spastic quadriplegia with accompanying transient nystagmus and varying degrees of intellectual disability. Neuroimaging shows brain atrophy and ventriculomegaly. {ECO:0000269|PubMed:16301218}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Adapter protein that links structural and signaling protein complexes positioned to guide microtubule and actin cytoskeleton dynamics during cell morphogenesis (PubMed:22084092, PubMed:24120883). At focal adhesions (FAs) rims, organizes cortical microtubule stabilizing complexes (CMSCs) and directly interacts with major FA component TLN1, forming macromolecular assemblies positioned to control microtubule-actin crosstalk at the cell edge (PubMed:24120883, PubMed:27410476). Recruits KIF21A in CMSCs at axonal growth cones and regulates axon guidance by suppressing microtubule growth without inducing microtubule disassembly once it reaches the cell cortex (PubMed:24120883). Interacts with ARFGEF1 and participates in establishing microtubule-organizing center (MTOC) orientation and directed cell movement in wound healing (PubMed:22084092). Regulates actin stress fiber formation and cell migration by inhibiting RHOA activation in response to growth factors; this function involves phosphorylation through PI3K/Akt signaling and may depend on the competitive interaction with 14-3-3 adapter proteins to sequester them from active complexes (PubMed:18458160, PubMed:25961457). Inhibits the formation of lamellipodia but not of filopodia; this function may depend on the competitive interaction with BAIAP2 to block its association with activated RAC1. Inhibits fibronectin-mediated cell spreading; this function is partially mediated by BAIAP2 (PubMed:19171758). In the nucleus, is involved in beta-catenin-dependent activation of transcription (PubMed:16968744). During cell division, may regulate DAAM1-dependent RHOA activation that signals centrosome maturation and chromosomal segregation. May also be involved in contractile ring formation during cytokinesis (By similarity). Potential tumor suppressor for renal cell carcinoma (Probable). {ECO:0000250|UniProtKB:E9Q238, ECO:0000269|PubMed:16968744, ECO:0000269|PubMed:18458160, ECO:0000269|PubMed:19171758, ECO:0000269|PubMed:22084092, ECO:0000269|PubMed:24120883, ECO:0000269|PubMed:25961457, ECO:0000269|PubMed:27410476, ECO:0000305|PubMed:12133830}.
uniprot
proteins
mass_dalton
147289
uniprot
proteins
mutagenesis
MUTAGEN 41; /note="L->A: Abolishes binding to TLN1 and impairs CMSC assembly at the focal adhesion rims leading to increased microtubule growth rate at the cell periphery; when associated with A-42, A-43 and A-44."; /evidence="ECO:0000269|PubMed:27410476"; MUTAGEN 42; /note="D->A: Abolishes binding to TLN1 and impairs CMSC assembly at the focal adhesion rims leading to increased microtubule growth rate at the cell periphery; when associated with A-41, A-43 and A-44."; /evidence="ECO:0000269|PubMed:27410476"; MUTAGEN 43; /note="L->A: Nuclear localization; when associated A-52; A-125; A-129; A-134; A-613; A-616; A-620 and A-622. Abolishes binding to TLN1 and impairs CMSC assembly at the focal adhesion rims leading to increased microtubule growth rate at the cell periphery; when associated with A-41, A-42 and A-44."; /evidence="ECO:0000269|PubMed:16968744, ECO:0000269|PubMed:27410476"; MUTAGEN 44; /note="D->A: Abolishes binding to TLN1 and impairs CMSC assembly at the focal adhesion rims leading to increased microtubule growth rate at the cell periphery; when associated with A-41, A-42 and A-43."; /evidence="ECO:0000269|PubMed:27410476"; MUTAGEN 52; /note="I->A: Nuclear localization; when associated A-43; A-125; A-129; A-134; A-613; A-616; A-620 and A-622."; /evidence="ECO:0000269|PubMed:16968744"; MUTAGEN 65..68; /note="KRRK->AAAA: Enhanced cytoplasmic localization; when associated with 979-A--A-981 and 991-A-A-992."; /evidence="ECO:0000269|PubMed:16968744"; MUTAGEN 125; /note="L->A: Nuclear localization; when associated A-43; A-52; A-129; A-134; A-613; A-616; A-620 and A-622."; /evidence="ECO:0000269|PubMed:16968744"; MUTAGEN 129; /note="L->A: Nuclear localization; when associated A-43; A-52; A-125; A-134; A-613; A-616; A-620 and A-622."; /evidence="ECO:0000269|PubMed:16968744"; MUTAGEN 134; /note="I->A: Nuclear localization; when associated A-43; A-52; A-125; A-129; A-613; A-616; A-620 and A-622."; /evidence="ECO:0000269|PubMed:16968744"; MUTAGEN 325; /note="S->A: Abolishes phosphorylation by PKB. Abolishes interaction with YWHAB; YWHAG; YWHAE; YWHAH; YWHAQ; YWHAZ and SFN."; /evidence="ECO:0000269|PubMed:18458160"; MUTAGEN 613; /note="L->A: Nuclear localization; when associated A-43; A-52; A-125; A-129; A-134; A-616; A-620 and A-622."; /evidence="ECO:0000269|PubMed:16968744"; MUTAGEN 616; /note="L->A: Nuclear localization; when associated A-43; A-52; A-125; A-129; A-134; A-613; A-620 and A-622."; /evidence="ECO:0000269|PubMed:16968744"; MUTAGEN 620; /note="L->A: Nuclear localization; when associated A-43; A-52; A-125; A-129; A-134; A-613; A-616 and A-622."; /evidence="ECO:0000269|PubMed:16968744"; MUTAGEN 622; /note="L->A: Nuclear localization; when associated A-43; A-52; A-125; A-129; A-134; A-613; A-616 and A-620."; /evidence="ECO:0000269|PubMed:16968744"; MUTAGEN 979..981; /note="KKK->AAA: Enhanced cytoplasmic localization; when associated with 65-A--A-68 and 991-A-A-992."; /evidence="ECO:0000269|PubMed:16968744"; MUTAGEN 991..992; /note="KK->AA: Enhanced cytoplasmic localization; when associated with 65-A--68 and 979-A--A-981."; /evidence="ECO:0000269|PubMed:16968744"; MUTAGEN 1197; /note="Y->A: 4.5-fold decrease in binding to KIF21A."; /evidence="ECO:0000269|PubMed:29183992"; MUTAGEN 1197; /note="Y->L: Very weak binding affinity for KIF21A."; /evidence="ECO:0000269|PubMed:29183992"; MUTAGEN 1276; /note="E->H: Abolishes binding to KIF21A."; /evidence="ECO:0000269|PubMed:29183992"; MUTAGEN 1298; /note="D->A: 15-fold decrease in binding to KIF21A."; /evidence="ECO:0000269|PubMed:29183992"; MUTAGEN 1300; /note="D->A: 10-fold decrease in binding to KIF21A."; /evidence="ECO:0000269|PubMed:29183992
uniprot
proteins
pubmed
12133830
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15823577
uniprot
proteins
pubmed
16301218
uniprot
proteins
pubmed
16968744
uniprot
proteins
pubmed
18458160
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19171758
uniprot
proteins
pubmed
19559006
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22084092
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24120883
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25961457
uniprot
proteins
pubmed
27410476
uniprot
proteins
pubmed
28284839
uniprot
proteins
pubmed
29183992
uniprot
proteins
pubmed
8724849
uniprot
proteins
sequence_length
1352
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cell cortex {ECO:0000269|PubMed:24120883, ECO:0000269|PubMed:27410476}. Cell projection, ruffle membrane {ECO:0000269|PubMed:19559006}; Peripheral membrane protein {ECO:0000305|PubMed:27410476}. Cytoplasm {ECO:0000269|PubMed:12133830, ECO:0000269|PubMed:16968744}. Nucleus {ECO:0000269|PubMed:16968744}. Note=Shuttles between the cytoplasm and nucleus (PubMed:16968744). Colocalizes with CMSC components at focal adhesion rims. Colocalizes with KIF21A in membrane ruffles (PubMed:19559006, PubMed:27410476). Colocalizes with RHOA at the contractile ring. Colocalizes with RHOA and DAAM1 around centrosomes. {ECO:0000250|UniProtKB:E9Q238, ECO:0000269|PubMed:16968744, ECO:0000269|PubMed:19559006, ECO:0000269|PubMed:27410476}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:16968744, ECO:0000269|PubMed:25961457}. Nucleus {ECO:0000269|PubMed:16968744, ECO:0000269|PubMed:25961457}. Note=Shuttles between the cytoplasm and nucleus. {ECO:0000269|PubMed:16968744}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:16968744}. Nucleus {ECO:0000269|PubMed:16968744}. Note=Shuttles between the cytoplasm and nucleus. {ECO:0000269|PubMed:16968744}.
uniprot
proteins