SHFL
entrez
55337
canonical
uniprot
Q9NUL5
canonical
ensembl
ENSG00000130813
resolver
ensp
ENSP00000253110
resolver
ensp
ENSP00000380978
resolver
ensp
ENSP00000467182
resolver
ensp
ENSP00000657908
resolver
genesymbol
SHFL
resolver
genesymbol_syn
C19orf66
resolver
genesymbol_syn
FLJ11286
resolver
genesymbol_syn
IRAV
resolver
genesymbol_syn
RYDEN
resolver
genesymbol_syn
SFL
resolver
hgnc
HGNC:25649
resolver
uniprot
A8MQT9
resolver
uniprot
Q4G188
resolver
uniprot
Q8IYH6
resolver
uniprot
Q8N8V1
resolver
uniprot_entry
SHFL_HUMAN
resolver
uniprot_sec
A8MQT9
resolver
uniprot_sec
Q4G188
resolver
uniprot_sec
Q8IYH6
resolver
uniprot_sec
Q8N8V1
resolver
amino_acid_sequence
MSQEGVELEKSVRRLREKFHGKVSSKKAGALMRKFGSDHTGVGRSIVYGVKQKDGQELSNDLDAQDPPEDMKQDRDIQAVATSLLPLTEANLRMFQRAQDDLIPAVDRQFACSSCDHVWWRRVPQRKEVSRCRKCRKRYEPVPADKMWGLAEFHCPKCRHNFRGWAQMGSPSPCYGCGFPVYPTRILPPRWDRDPDRRSTHTHSCSAADCYNRREPHVPGTSCAHPKSRKQNHLPKVLHPSNPHISSGSTVATCLSQGGLLEDLDNLILEDLKEEEEEEEEVEDEEGGPRE
uniprot
proteins
function
FUNCTION: Inhibits programmed -1 ribosomal frameshifting (-1PRF) of a variety of mRNAs from viruses, such as HIV1, and cellular genes, such as PEG10. Interacts with the -1PRF signal of target mRNA and translating ribosomes and causes premature translation termination at the frameshifting site (PubMed:30682371). Regulates HIV1 GAG-POL expression by inhibiting -1PRF (PubMed:30682371). Exhibits antiviral activity against dengue virus (DENV) and can inhibit the replication of all DENV serotypes. May block the protein translation of DENV RNA via its association with cellular mRNA-binding proteins and viral RNA. Also interrupts Zika virus replication by promoting viral NS3 degradation via a lysosome-dependent pathway (PubMed:32150556). Can also limit the replication of hepatitis C virus (HCV) by restricting formation of viral replication organelle, West Nile virus (WNV), Chikungunya virus (CHIKV), herpes simplex virus type 1 (HHV-1), herpes virus type 8 (HHV-8) and human adenovirus (PubMed:26735137, PubMed:27974568, PubMed:30944177, PubMed:32294532). Binds nucleic acids with a higher affinity for ssRNA and ssDNA than for dsDNA (PubMed:27974568). {ECO:0000269|PubMed:26735137, ECO:0000269|PubMed:27974568, ECO:0000269|PubMed:30682371, ECO:0000269|PubMed:30944177, ECO:0000269|PubMed:32150556, ECO:0000269|PubMed:32294532}.; FUNCTION: Isoform 4 does not inhibit programmed ribosomal frameshifting (-1PRF). Does not bind to ribosomes. {ECO:0000269|PubMed:30682371}.
uniprot
proteins
mass_dalton
33110
uniprot
proteins
mutagenesis
MUTAGEN 121..137; /note="RRVPQRKEVSRCRKCRK->AAVPQAAEVSACAACAA: Decreased efficiency in the interaction with PABPC1 and reduced inhibitory activity against DENV replication."; /evidence="ECO:0000269|PubMed:26735137
uniprot
proteins
protein_family
SHFL family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26735137
uniprot
proteins
pubmed
27974568
uniprot
proteins
pubmed
30682371
uniprot
proteins
pubmed
30944177
uniprot
proteins
pubmed
32150556
uniprot
proteins
pubmed
32294532
uniprot
proteins
sequence_length
291
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:26735137, ECO:0000269|PubMed:32150556}. Nucleus {ECO:0000269|PubMed:26735137}. Cytoplasm, P-body {ECO:0000269|PubMed:27974568}. Note=Predominantly found in the cytoplasm (PubMed:26735137). After infection, relocalizes to the DENV replication complex in perinuclear regions (PubMed:27974568). {ECO:0000269|PubMed:26735137, ECO:0000269|PubMed:27974568}.
uniprot
proteins