PCGF1
entrez
84759
canonical
uniprot
Q9BSM1
canonical
ensembl
ENSG00000115289
resolver
ensp
ENSP00000233630
resolver
genesymbol
PCGF1
resolver
genesymbol_syn
NSPC1
resolver
genesymbol_syn
RNF68
resolver
hgnc
HGNC:17615
resolver
uniprot
Q7Z506
resolver
uniprot_entry
PCGF1_HUMAN
resolver
uniprot_sec
Q7Z506
resolver
amino_acid_sequence
MASPQGGQIAIAMRLRNQLQSVYKMDPLRNEEEVRVKIKDLNEHIVCCLCAGYFVDATTITECLHTFCKSCIVKYLQTSKYCPMCNIKIHETQPLLNLKLDRVMQDIVYKLVPGLQDSEEKRIREFYQSRGLDRVTQPTGEEPALSNLGLPFSSFDHSKAHYYRYDEQLNLCLERLSSGKDKNKSVLQNKYVRCSVRAEVRHLRRVLCHRLMLNPQHVQLLFDNEVLPDHMTMKQIWLSRWFGKPSPLLLQYSVKEKRR
uniprot
proteins
function
FUNCTION: Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells (PubMed:26687479). {ECO:0000269|PubMed:15620699, ECO:0000269|PubMed:16943429, ECO:0000269|PubMed:17088287, ECO:0000269|PubMed:26151332, ECO:0000269|PubMed:26687479}.
uniprot
proteins
mass_dalton
30346
uniprot
proteins
mutagenesis
MUTAGEN 109; /note="Y->F: Marked decrease of repressor activity. May be a kinase phosphorylation site."; /evidence="ECO:0000269|PubMed:15620699"; MUTAGEN 191; /note="Y->A: Abolishes interaction with BCOR and BCORL1."; /evidence="ECO:0000269|PubMed:23523425"; MUTAGEN 193; /note="R->A: Abolishes interaction with BCOR and BCORL1."; /evidence="ECO:0000269|PubMed:23523425"; MUTAGEN 195; /note="S->F: Abolishes repressor activity. May be a PKC phosphorylation site."; /evidence="ECO:0000269|PubMed:15620699"; MUTAGEN 206; /note="V->D: Abolishes interaction with BCOR and BCORL1."; /evidence="ECO:0000269|PubMed:23523425
uniprot
proteins
pubmed
11287196
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15620699
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16943429
uniprot
proteins
pubmed
17088287
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21282530
uniprot
proteins
pubmed
23523425
uniprot
proteins
pubmed
26151332
uniprot
proteins
pubmed
26687479
uniprot
proteins
pubmed
27568929
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
259
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15620699, ECO:0000269|PubMed:21282530}.
uniprot
proteins