CRTAM
entrez
56253
canonical
uniprot
O95727
canonical
ensembl
ENSG00000109943
resolver
ensp
ENSP00000227348
resolver
ensp
ENSP00000433728
resolver
genesymbol
CRTAM
resolver
hgnc
HGNC:24313
resolver
uniprot
Q59EI1
resolver
uniprot
Q6IRX2
resolver
uniprot_entry
CRTAM_HUMAN
resolver
uniprot_sec
Q59EI1
resolver
uniprot_sec
Q6IRX2
resolver
amino_acid_sequence
MWWRVLSLLAWFPLQEASLTNHTETITVEEGQTLTLKCVTSLRKNSSLQWLTPSGFTIFLNEYPALKNSKYQLLHHSANQLSITVPNVTLQDEGVYKCLHYSDSVSTKEVKVIVLATPFKPILEASVIRKQNGEEHVVLMCSTMRSKPPPQITWLLGNSMEVSGGTLHEFETDGKKCNTTSTLIIHTYGKNSTVDCIIRHRGLQGRKLVAPFRFEDLVTDEETASDALERNSLSSQDPQQPTSTVSVTEDSSTSEIDKEEKEQTTQDPDLTTEANPQYLGLARKKSGILLLTLVSFLIFILFIIVQLFIMKLRKAHVIWKKENEVSEHTLESYRSRSNNEETSSEEKNGQSSHPMRCMNYITKLYSEAKTKRKENVQHSKLEEKHIQVPESIV
uniprot
proteins
function
FUNCTION: Mediates heterophilic cell-cell adhesion which regulates the activation, differentiation and tissue retention of various T-cell subsets (By similarity). Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and IFNG/interferon-gamma secretion by CD8+ T-cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM1 in vivo (PubMed:15811952). Regulates CD8+ T-cell proliferation in response to T-cell receptor (TCR) activation (By similarity). Appears to be dispensable for CD8+ T-cell-mediated cytotoxicity (By similarity). Interaction with SCRIB promotes the late phase of cellular polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG, IL17 and IL22 production (By similarity). By interacting with CADM1 on CD8+ dendritic cells, regulates the retention of activated CD8+ T-cells within the draining lymph node (By similarity). Required for the intestinal retention of intraepithelial CD4+ CD8+ T-cells and, to a lesser extent, intraepithelial and lamina propria CD8+ T-cells and CD4+ T-cells (By similarity). Interaction with CADM1 promotes the adhesion to gut-associated CD103+ dendritic cells, which may facilitate the expression of gut-homing and adhesion molecules on T-cells and the conversion of CD4+ T-cells into CD4+ CD8+ T-cells (By similarity). {ECO:0000250|UniProtKB:Q149L7, ECO:0000269|PubMed:15811952}.
uniprot
proteins
mass_dalton
44641
uniprot
proteins
mutagenesis
MUTAGEN 56; /note="F->A: Reduced binding to CADM1. Severely impairs interaction with CADM1; when associated with A-57, A-67 and A-101."; /evidence="ECO:0000269|PubMed:23871486"; MUTAGEN 57; /note="T->A: Reduced binding to CADM1. Severely impairs interaction with CADM1; when associated with A-56, A-67 and A-101."; /evidence="ECO:0000269|PubMed:23871486"; MUTAGEN 67; /note="K->A: Reduced binding to CADM1. Severely impairs interaction with CADM1; when associated with A-56, A-57 and A-101."; /evidence="ECO:0000269|PubMed:23871486"; MUTAGEN 101; /note="Y->A: Reduced binding to CADM1. Severely impairs interaction with CADM1; when associated with A-56, A-57 and A-67."; /evidence="ECO:0000269|PubMed:23871486
uniprot
proteins
protein_family
Nectin family
uniprot
proteins
pubmed
10811014
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15781451
uniprot
proteins
pubmed
15811952
uniprot
proteins
pubmed
16300832
uniprot
proteins
pubmed
23583034
uniprot
proteins
pubmed
23871486
uniprot
proteins
sequence_length
393
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q149L7}; Single-pass type I membrane protein {ECO:0000255}. Note=In a subset of CD4+ T-cells, colocalizes with SCRIB at the immunological synapse during the late phase of T-cell activation. {ECO:0000250|UniProtKB:Q149L7}.
uniprot
proteins
transmembrane_region
TRANSMEM 288..308; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins