RRN3
entrez
54700
canonical
uniprot
Q9NYV6
canonical
ensembl
ENSG00000085721
resolver
ensembl
ENSG00000278494
resolver
ensp
ENSP00000198767
resolver
ensp
ENSP00000402027
resolver
ensp
ENSP00000487970
resolver
enst
ENST00000429751
resolver
enst
ENST00000631800
resolver
genesymbol
RRN3
resolver
genesymbol_syn
TIFIA
resolver
hgnc
HGNC:30346
resolver
uniprot
A2RTY9
resolver
uniprot
B4E0J7
resolver
uniprot
B4E3T2
resolver
uniprot
B7ZB55
resolver
uniprot
F5H148
resolver
uniprot
Q3MHU9
resolver
uniprot
Q6IPL4
resolver
uniprot
Q9H4F0
resolver
uniprot_entry
B7ZB55_HUMAN
resolver
uniprot_entry
F5H148_HUMAN
resolver
uniprot_entry
RRN3_HUMAN
resolver
uniprot_sec
A2RTY9
resolver
uniprot_sec
B4E0J7
resolver
uniprot_sec
B4E3T2
resolver
uniprot_sec
Q3MHU9
resolver
uniprot_sec
Q6IPL4
resolver
uniprot_sec
Q9H4F0
resolver
amino_acid_sequence
MAAPLLHTRLPGDAAASSSAVKKLGASRTGISNMRALENDFFNSPPRKTVRFGGTVTEVLLKYKKGETNDFELLKNQLLDPDIKDDQIINWLLEFRSSIMYLTKDFEQLISIILRLPWLNRSQTVVEEYLAFLGNLVSAQTVFLRPCLSMIASHFVPPRVIIKEGDVDVSDSDDEDDNLPANFDTCHRALQIIARYVPSTPWFLMPILVEKFPFVRKSERTLECYVHNLLRISVYFPTLRHEILELIIEKLLKLDVNASRQGIEDAEETATQTCGGTDSTEGLFNMDEDEETEHETKAGPERLDQMVHPVAERLDILMSLVLSYMKDVCYVDGKVDNGKTKDLYRDLINIFDKLLLPTHASCHVQFFMFYLCSFKLGFAEAFLEHLWKKLQDPSNPAIIRQAAGNYIGSFLARAKFIPLITVKSCLDLLVNWLHIYLNNQDSGTKAFCDVALHGPFYSACQAVFYTFVFRHKQLLSGNLKEGLQYLQSLNFERIVMSQLNPLKICLPSVVNFFAAITNKYQLVFCYTIIERNNRQMLPVIRSTAGGDSVQICTNPLDTFFPFDPCVLKRSKKFIDPIYQVWEDMSAEELQEFKKPMKKDIVEDEDDDFLKGEVPQNDTVIGITPSSFDTHFRSPSSSVGSPPVLYMQPSPL
uniprot
proteins
function
FUNCTION: Required for efficient transcription initiation by RNA polymerase I (Pol I). Required for the formation of the competent pre-initiation complex (PIC). {ECO:0000250, ECO:0000269|PubMed:10758157, ECO:0000269|PubMed:11250903, ECO:0000269|PubMed:11265758, ECO:0000269|PubMed:15805466}.
uniprot
proteins
mass_dalton
74107
uniprot
proteins
mutagenesis
MUTAGEN 411..415; /note="Missing: Abolishes interaction with TAF1B and TAF1C."; /evidence="ECO:0000269|PubMed:12393749
uniprot
proteins
post_translational_modification
PTM: Phosphorylation is required for participation in rDNA transcription (By similarity). Phosphorylated at Thr-200 by MAPK9/JNK2, which abrogates initiation complex formation. {ECO:0000250, ECO:0000269|PubMed:15805466}.
uniprot
proteins
protein_family
RRN3 family
uniprot
proteins
pubmed
10758157
uniprot
proteins
pubmed
11250903
uniprot
proteins
pubmed
11265758
uniprot
proteins
pubmed
12393749
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
15805466
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
651
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:11250903}.
uniprot
proteins