TRAF3IP3
entrez
80342
canonical
uniprot
Q9Y228
canonical
ensembl
ENSG00000009790
resolver
ensp
ENSP00000355990
resolver
ensp
ENSP00000355991
resolver
ensp
ENSP00000355992
resolver
ensp
ENSP00000355993
resolver
ensp
ENSP00000383743
resolver
ensp
ENSP00000677679
resolver
ensp
ENSP00000709426
resolver
ensp
ENSP00000709427
resolver
enst
ENST00000367023
resolver
enst
ENST00000400959
resolver
genesymbol
TRAF3IP3
resolver
genesymbol_syn
T3JAM
resolver
hgnc
HGNC:30766
resolver
uniprot
A1L464
resolver
uniprot
A6NIU9
resolver
uniprot
B1AJU2
resolver
uniprot
B3KWQ9
resolver
uniprot
E2QRE5
resolver
uniprot
Q2YDB5
resolver
uniprot
Q4VY06
resolver
uniprot
Q7Z706
resolver
uniprot_entry
B1AJU2_HUMAN
resolver
uniprot_entry
B3KWQ9_HUMAN
resolver
uniprot_entry
E2QRE5_HUMAN
resolver
uniprot_entry
T3JAM_HUMAN
resolver
uniprot_sec
A1L464
resolver
uniprot_sec
A6NIU9
resolver
uniprot_sec
Q2YDB5
resolver
uniprot_sec
Q4VY06
resolver
uniprot_sec
Q7Z706
resolver
amino_acid_sequence
MISPDPRPSPGLARWAESYEAKCERRQEIRESRRCRPNVTTCRQVGKTLRIQQREQLQRARLQQFFRRRNLELEEKGKAQHPQAREQGPSRRPGQVTVLKEPLSCARRISSPREQVTGTSSEVFPAQHPPPSGICRDLSDHLSSQAGGLPPQDTPIKKPPKHHRGTQTKAEGPTIKNDASQQTNYGVAVLDKEIIQLSDYLKEALQRELVLKQKMVILQDLLSTLIQASDSSWKGQLNEDKLKGKLRSLENQLYTCTQKYSPWGMKKVLLEMEDQKNSYEQKAKESLQKVLEEKMNAEQQLQSTQRSLALAEQKCEEWRSQYEALKEDWRTLGTQHRELESQLHVLQSKLQGADSRDLQMNQALRFLENEHQQLQAKIECLQGDRDLCSLDTQDLQDQLKRSEAEKLTLVTRVQQLQGLLQNQSLQLQEQEKLLTKKDQALPVWSPKSFPNEVEPEGTGKEKDWDLRDQLQKKTLQLQAKEKECRELHSELDNLSDEYLSCLRKLQHCREELNQSQQLPPRRQCGRWLPVLMVVIAAALAVFLANKDNLMI
uniprot
proteins
function
FUNCTION: Adapter protein that plays essential roles in both innate and adaptive immunity. Plays a crucial role in the regulation of thymocyte development (PubMed:26195727). Mechanistically, mediates TCR-stimulated activation through recruiting MAP2K1/MEK1 to the Golgi and, thereby, facilitating the interaction of MAP2K1/MEK1 with its activator BRAF (PubMed:26195727). Also plays an essential role in regulatory T-cell stability and function by recruiting the serine-threonine phosphatase catalytic subunit (PPP2CA) to the lysosome, thereby facilitating the interaction of PP2Ac with the mTORC1 component RPTOR and restricting glycolytic metabolism (PubMed:30115741). Positively regulates TLR4 signaling activity in macrophage-mediated inflammation by acting as a molecular clamp to facilitate LPS-induced translocation of TLR4 to lipid rafts (PubMed:30573680). In response to viral infection, facilitates the recruitment of TRAF3 to MAVS within mitochondria leading to IRF3 activation and interferon production (PubMed:31390091). However, participates in the maintenance of immune homeostasis and the prevention of overzealous innate immunity by promoting 'Lys-48'-dependent ubiquitination of TBK1 (PubMed:32366851). {ECO:0000269|PubMed:26195727, ECO:0000269|PubMed:30115741, ECO:0000269|PubMed:30573680, ECO:0000269|PubMed:31390091, ECO:0000269|PubMed:32366851}.
uniprot
proteins
mass_dalton
63626
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26195727
uniprot
proteins
pubmed
30115741
uniprot
proteins
pubmed
30573680
uniprot
proteins
pubmed
31390091
uniprot
proteins
pubmed
32366851
uniprot
proteins
sequence_length
551
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:30573680}. Golgi apparatus membrane {ECO:0000269|PubMed:26195727}; Single-pass type IV membrane protein {ECO:0000305}. Lysosome membrane {ECO:0000250|UniProtKB:Q8C0G2}. Mitochondrion outer membrane {ECO:0000269|PubMed:31390091}. Note=Accumulates on the mitochondria after virus infection. {ECO:0000269|PubMed:31390091}.
uniprot
proteins
transmembrane_region
TRANSMEM 527..544; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins