Ints6
entrez
18130
canonical
uniprot
Q6PCM2
canonical
ensembl
ENSMUSG00000035161
resolver
ensp
ENSMUSP00000086788
resolver
ensp
ENSMUSP00000152954
resolver
ensp
ENSMUSP00000322374
resolver
ensp
ENSMUSP00000322375
resolver
ensp
ENSMUSP00000322380
resolver
ensp
ENSMUSP00000322381
resolver
genesymbol
Ints6
resolver
genesymbol_syn
Dbi1
resolver
uniprot
Q3TA02
resolver
uniprot
Q61204
resolver
uniprot
Q6PDL7
resolver
uniprot
Q8BQZ7
resolver
uniprot_entry
INT6_MOUSE
resolver
uniprot_sec
Q3TA02
resolver
uniprot_sec
Q61204
resolver
uniprot_sec
Q6PDL7
resolver
uniprot_sec
Q8BQZ7
resolver
amino_acid_sequence
MPILLFLIDTSASMNQRSHLGTTYLDTAKGAVETFMKLRARDPASRGDRYMLVTFEEPPYAIKAGWKENHATFMNELKNLQAEGLTTLGQSLRTAFDLLNLNRLVTGIDNYGQGRNPFFLEPAIIITITDGSKLTTTSGVQDELHLPLNSPLPGSELTKEPFRWDQRLFALVLRLPGTMSVESEQLTGVPLDDSAITPMCEVTGGRSYSVCSPRMLNQCLESLVQKVQSGVVINFEKAGPDPPPAEEGQPDISRPFGSQPWHSCHKLIYVRPNPKTGVPIGHWPVPESFWPDQNSPTLPPRTSHPVVKFSCTDCEPMVIDKLPFDKYELEPSPLTQFILERKSPQTCWQVYVSNSAKYNELGHPFGYLKASTALTCVNLFVMPYNYPVLLPLLDDLFKVHKAKPTLKWRQSFESYLKTMPPYYLGPLKKAVRMMGAPNLIADSMEYGLSYSVISYLKKLSQQAKIESDRVIGSVGKKVVQETGIKVRSRSHGLSMAHRKGFQVLQGISEDVPHRLLDLNMKEYTGFQVALLNKDLKPQTFRNAYDIPRRNLLDHLTRMRSNLLKSTRKFLKGQDEDQVHSVPIAQMGNYQEYLKQVPSPLRELDPDQPRRLHTFGNPFKLDKKGMMIDEADEFVAGPQNKHKRPGEPSMQGIPKRRRCASPLLRGRRQSPAVNSHIGGKGPPAPMTQAQPGLIKPLPLHKEATNDSIVDDVVENHVADQLSSDMTPNAMDTEFLTSPPNLLEPSTNHTEALGHEHLGNNDLTVGGFLENHEEPRNKEQSAEENIPASSLNKGKKLMHCRSHEEVNTELKAQIMKEIRKPGRKYERIFTLLKHVQGSLQTRLIFLQNVIKEASRFKKRMLIEQLENFLDEIHRRANQINHINSN
uniprot
proteins
function
FUNCTION: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Within the integrator complex, INTS6 acts as a molecular adapter that promotes assembly of protein phosphatase 2A (PP2A) subunits to the integrator core complex, promoting recruitment of PP2A to transcription pause-release checkpoint. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex. {ECO:0000250|UniProtKB:Q9UL03}.
uniprot
proteins
mass_dalton
99661
uniprot
proteins
protein_family
Integrator subunit 6 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9473344
uniprot
proteins
sequence_length
883
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UL03}. Chromosome {ECO:0000250|UniProtKB:Q9UL03}. Note=Associates with chromatin and transcription pause-release checkpoint. {ECO:0000250|UniProtKB:Q9UL03}.
uniprot
proteins