Scn11a
entrez
29701
canonical
uniprot
O88457
canonical
ensembl
ENSRNOG00000032884
resolver
ensp
ENSRNOP00000033224
resolver
genesymbol
Scn11a
resolver
genesymbol_syn
Nan
resolver
genesymbol_syn
Sns2
resolver
uniprot_entry
SCNBA_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activity is not sensitive to inhibition by tetrodotoxin. {ECO:0000269|PubMed:10196578}.
uniprot
proteins
amino_acid_sequence
MEERYYPVIFPDERNFRPFTSDSLAAIEKRIAIQKERKKSKDKAAAEPQPRPQLDLKASRKLPKLYGDIPPELVAKPLEDLDPFYKDHKTFMVLNKKRTIYRFSAKRALFILGPFNPLRSLMIRISVHSVFSMFIICTVIINCMFMANSMERSFDNDIPEYVFIGIYILEAVIKILARGFIVDEFSFLRDPWNWLDFIVIGTAIATCFPGSQVNLSALRTFRVFRALKAISVISGLKVIVGALLRSVKKLVDVMVLTLFCLSIFALVGQQLFMGILNQKCIKHNCGPNPASNKDCFEKEKDSEDFIMCGTWLGSRPCPNGSTCDKTTLNPDNNYTKFDNFGWSFLAMFRVMTQDSWERLYRQILRTSGIYFVFFFVVVIFLGSFYLLNLTLAVVTMAYEEQNRNVAAETEAKEKMFQEAQQLLREEKEALVAMGIDRSSLNSLQASSFSPKKRKFFGSKTRKSFFMRGSKTAQASASDSEDDASKNPQLLEQTKRLSQNLPVDLFDEHVDPLHRQRALSAVSILTITMQEQEKFQEPCFPCGKNLASKYLVWDCSPQWLCIKKVLRTIMTDPFTELAITICIIINTVFLAVEHHNMDDNLKTILKIGNWVFTGIFIAEMCLKIIALDPYHYFRHGWNVFDSIVALLSLADVLYNTLSDNNRSFLASLRVLRVFKLAKSWPTLNTLIKIIGHSVGALGNLTVVLTIVVFIFSVVGMRLFGTKFNKTAYATQERPRRRWHMDNFYHSFLVVFRILCGEWIENMWGCMQDMDGSPLCIIVFVLIMVIGKLVVLNLFIALLLNSFSNEEKDGSLEGETRKTKVQLALDRFRRAFSFMLHALQSFCCKKCRRKNSPKPKETTESFAGENKDSILPDARPWKEYDTDMALYTGQAGAPLAPLAEVEDDVEYCGEGGALPTSQHSAGVQAGDLPPETKQLTSPDDQGVEMEVFSEEDLHLSIQSPRKKSDAVSMLSECSTIDLNDIFRNLQKTVSPKKQPDRCFPKGLSCHFLCHKTDKRKSPWVLWWNIRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVNLPSRPQVEKLLRCTDNIFTFIFLLEMILKWVAFGFRRYFTSAWCWLDFLIVVVSVLSLMNLPSLKSFRTLRALRPLRALSQFEGMKVVVYALISAIPAILNVLLVCLIFWLVFCILGVNLFSGKFGRCINGTDINMYLDFTEVPNRSQCNISNYSWKVPQVNFDNVGNAYLALLQVATYKGWLEIMNAAVDSREKDEQPDFEANLYAYLYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGTKKPQKPIPRPLNKCQAFVFDLVTSQVFDVIILGLIVLNMIIMMAESADQPKDVKKTFDILNIAFVVIFTIECLIKVFALRQHYFTNGWNLFDCVVVVLSIISTLVSRLEDSDISFPPTLFRVVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLVMFIYAIFGMSWFSKVKKGSGIDDIFNFETFTGSMLCLFQITTSAGWDTLLNPMLEAKEHCNSSSQDSCQQPQIAVVYFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLGEDDFEIFYEVWEKFDPEASQFIQYSALSDFADALPEPLRVAKPNKFQFLVMDLPMVMGDRLHCMDVLFAFTTRVLGDSSGLDTMKTMMEEKFMEANPFKKLYEPIVTTTKRKEEEQGAAVIQRAYRKHMEKMVKLRLKDRSSSSHQVFCNGDLSSLDVAKVKVHND
uniprot
proteins
function
FUNCTION: Sodium channel mediating the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient (PubMed:10196578). Involved in membrane depolarization during action potential in nociceptors which function as key relay stations for the electrical transmission of pain signals from the periphery to the central nervous system. Also involved in rapid BDNF-evoked neuronal depolarization (By similarity). {ECO:0000250|UniProtKB:Q9UI33, ECO:0000269|PubMed:10196578}.
uniprot
proteins
mass_dalton
201845
uniprot
proteins
protein_family
Nav1.9/SCN11A subfamily
uniprot
proteins
protein_family
Sodium channel (TC 1.A.1.10) family
uniprot
proteins
pubmed
10196578
uniprot
proteins
pubmed
11487631
uniprot
proteins
pubmed
12536125
uniprot
proteins
pubmed
9671787
uniprot
proteins
sequence_length
1765
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10196578}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 127..148; /note="Helical; Name=S1 of repeat I"; /evidence="ECO:0000250"; TRANSMEM 158..177; /note="Helical; Name=S2 of repeat I"; /evidence="ECO:0000250"; TRANSMEM 190..209; /note="Helical; Name=S3 of repeat I"; /evidence="ECO:0000250"; TRANSMEM 217..236; /note="Helical; Voltage-sensor; Name=S4 of repeat I"; /evidence="ECO:0000250"; TRANSMEM 253..266; /note="Helical; Name=S5 of repeat I"; /evidence="ECO:0000250"; TRANSMEM 372..397; /note="Helical; Name=S6 of repeat I"; /evidence="ECO:0000250"; TRANSMEM 568..591; /note="Helical; Name=S1 of repeat II"; /evidence="ECO:0000250"; TRANSMEM 603..626; /note="Helical; Name=S2 of repeat II"; /evidence="ECO:0000250"; TRANSMEM 635..656; /note="Helical; Name=S3 of repeat II"; /evidence="ECO:0000250"; TRANSMEM 663..682; /note="Helical; Voltage-sensor; Name=S4 of repeat II"; /evidence="ECO:0000250"; TRANSMEM 698..720; /note="Helical; Name=S5 of repeat II"; /evidence="ECO:0000250"; TRANSMEM 773..798; /note="Helical; Name=S6 of repeat II"; /evidence="ECO:0000250"; TRANSMEM 1030..1052; /note="Helical; Name=S1 of repeat III"; /evidence="ECO:0000250"; TRANSMEM 1067..1092; /note="Helical; Name=S2 of repeat III"; /evidence="ECO:0000250"; TRANSMEM 1099..1116; /note="Helical; Name=S3 of repeat III"; /evidence="ECO:0000250"; TRANSMEM 1118..1139; /note="Helical; Voltage-sensor; Name=S4 of repeat III"; /evidence="ECO:0000250"; TRANSMEM 1159..1180; /note="Helical; Name=S5 of repeat III"; /evidence="ECO:0000250"; TRANSMEM 1262..1288; /note="Helical; Name=S6 of repeat III"; /evidence="ECO:0000250"; TRANSMEM 1342..1365; /note="Helical; Name=S1 of repeat IV"; /evidence="ECO:0000250"; TRANSMEM 1377..1400; /note="Helical; Name=S2 of repeat IV"; /evidence="ECO:0000250"; TRANSMEM 1407..1430; /note="Helical; Name=S3 of repeat IV"; /evidence="ECO:0000250"; TRANSMEM 1441..1463; /note="Helical; Voltage-sensor; Name=S4 of repeat IV"; /evidence="ECO:0000250"; TRANSMEM 1479..1501; /note="Helical; Name=S5 of repeat IV"; /evidence="ECO:0000250"; TRANSMEM 1560..1584; /note="Helical; Name=S6 of repeat IV"; /evidence="ECO:0000250
uniprot
proteins