BCL2L10
entrez
10017
canonical
uniprot
Q9HD36
canonical
ensembl
ENSG00000137875
resolver
ensp
ENSP00000260442
resolver
ensp
ENSP00000453562
resolver
enst
ENST00000260442
resolver
enst
ENST00000561198
resolver
genesymbol
BCL2L10
resolver
genesymbol_syn
BCL-B
resolver
genesymbol_syn
BCLB
resolver
genesymbol_syn
BOO
resolver
genesymbol_syn
DIVA
resolver
hgnc
HGNC:993
resolver
uniprot
H0YMD5
resolver
uniprot
Q3SX80
resolver
uniprot
Q52LQ9
resolver
uniprot
Q8TCS9
resolver
uniprot_entry
B2L10_HUMAN
resolver
uniprot_entry
H0YMD5_HUMAN
resolver
uniprot_sec
Q3SX80
resolver
uniprot_sec
Q52LQ9
resolver
uniprot_sec
Q8TCS9
resolver
amino_acid_sequence
MVDQLRERTTMADPLRERTELLLADYLGYCAREPGTPEPAPSTPEAAVLRSAAARLRQIHRSFFSAYLGYPGNRFELVALMADSVLSDSPGPTWGRVVTLVTFAGTLLERGPLVTARWKKWGFQPRLKEQEGDVARDCQRLVALLSSRLMGQHRAWLQAQGGWDGFCHFFRTPFPLAFWRKQLVQAFLSCLLTTAFIYLWTRLL
uniprot
proteins
function
FUNCTION: Promotes cell survival by suppressing apoptosis induced by BAX but not BAK (PubMed:11278245, PubMed:11689480). Increases binding of AHCYL1/IRBIT to ITPR1 (PubMed:27995898). Reduces ITPR1-mediated calcium release from the endoplasmic reticulum cooperatively with AHCYL1/IRBIT under normal cellular conditions (PubMed:27995898). Under apoptotic stress conditions, dissociates from ITPR1 and is displaced from mitochondria-associated endoplasmic reticulum membranes, leading to increased Ca(2+) transfer to mitochondria which promotes apoptosis (PubMed:27995898). Required for the correct formation of the microtubule organizing center during oocyte cell division, potentially via regulation of protein abundance and localization of other microtubule organizing center components such as AURKA and TPX2 (By similarity). {ECO:0000250|UniProtKB:Q9Z0F3, ECO:0000269|PubMed:11278245, ECO:0000269|PubMed:11689480, ECO:0000269|PubMed:27995898}.
uniprot
proteins
mass_dalton
23204
uniprot
proteins
mutagenesis
MUTAGEN 95; /note="G->A: Reduces interaction with BECN1 and BCL2L11."; /evidence="ECO:0000269|PubMed:22498477"; MUTAGEN 118..133; /note="Missing: Abolishes Ca(2+) binding."; /evidence="ECO:0000269|PubMed:21705382"; MUTAGEN 119; /note="K->R: Abolishes ubiquitination. No effect on localization to the mitochondria. No effect on interaction with BCL2L11, BIK, BBC3 or PMAIP1."; /evidence="ECO:0000269|PubMed:23563182"; MUTAGEN 120; /note="K->R: Abolishes ubiquitination. No effect on localization to the mitochondria. No effect on interaction with BCL2L11, BIK, BBC3 or PMAIP1."; /evidence="ECO:0000269|PubMed:23563182"; MUTAGEN 128; /note="K->R: Abolishes ubiquitination. No effect on localization to the mitochondria. No effect on interaction with BCL2L11, BIK, BBC3 or PMAIP1."; /evidence="ECO:0000269|PubMed:23563182"; MUTAGEN 131; /note="E->R: Abolishes Ca(2+) binding; when associated with N-133."; /evidence="ECO:0000269|PubMed:21705382"; MUTAGEN 133; /note="D->N: Abolishes Ca(2+) binding; when associated with R-131."; /evidence="ECO:0000269|PubMed:21705382"; MUTAGEN 178..191; /note="Missing: Abolishes interaction with NME2."; /evidence="ECO:0000269|PubMed:17532299
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated by UBQLN1; results in stabilization of BCL2L10 protein abundance and in relocalization from mitochondria to cytoplasm. {ECO:0000269|PubMed:22233804}.
uniprot
proteins
protein_family
Bcl-2 family
uniprot
proteins
pubmed
11278245
uniprot
proteins
pubmed
11593390
uniprot
proteins
pubmed
11689480
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
17532299
uniprot
proteins
pubmed
19255499
uniprot
proteins
pubmed
21705382
uniprot
proteins
pubmed
22233804
uniprot
proteins
pubmed
22498477
uniprot
proteins
pubmed
23235460
uniprot
proteins
pubmed
23563182
uniprot
proteins
pubmed
27995898
uniprot
proteins
pubmed
34245648
uniprot
proteins
sequence_length
204
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11593390, ECO:0000269|PubMed:21705382, ECO:0000269|PubMed:22233804, ECO:0000269|PubMed:22498477, ECO:0000269|PubMed:23563182}. Nucleus membrane {ECO:0000269|PubMed:11593390}. Endoplasmic reticulum {ECO:0000269|PubMed:22498477, ECO:0000269|PubMed:27995898}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9Z0F3}. Note=Localizes to mitochondria-associated endoplasmic reticulum membranes (MAMs) (PubMed:27995898). Localization to MAMs is greatly reduced under apoptotic stress conditions (PubMed:27995898). {ECO:0000269|PubMed:27995898}.
uniprot
proteins
transmembrane_region
TRANSMEM 183..200; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins