TMEM100
entrez
55273
canonical
uniprot
Q9NV29
canonical
ensembl
ENSG00000166292
resolver
ensp
ENSP00000395328
resolver
ensp
ENSP00000465638
resolver
ensp
ENSP00000563848
resolver
ensp
ENSP00000563849
resolver
ensp
ENSP00000563850
resolver
ensp
ENSP00000563851
resolver
ensp
ENSP00000563852
resolver
ensp
ENSP00000563853
resolver
ensp
ENSP00000563854
resolver
ensp
ENSP00000563855
resolver
ensp
ENSP00000563856
resolver
ensp
ENSP00000563857
resolver
ensp
ENSP00000563858
resolver
ensp
ENSP00000563859
resolver
ensp
ENSP00000563860
resolver
ensp
ENSP00000563861
resolver
ensp
ENSP00000563862
resolver
ensp
ENSP00000563863
resolver
ensp
ENSP00000563864
resolver
ensp
ENSP00000563865
resolver
ensp
ENSP00000563866
resolver
ensp
ENSP00000563867
resolver
ensp
ENSP00000563868
resolver
ensp
ENSP00000563869
resolver
ensp
ENSP00000563870
resolver
ensp
ENSP00000563871
resolver
ensp
ENSP00000618330
resolver
ensp
ENSP00000618331
resolver
enst
ENST00000424486
resolver
enst
ENST00000575734
resolver
enst
ENST00000893789
resolver
enst
ENST00000893790
resolver
enst
ENST00000893791
resolver
enst
ENST00000893792
resolver
enst
ENST00000893793
resolver
enst
ENST00000893794
resolver
enst
ENST00000893795
resolver
enst
ENST00000893796
resolver
enst
ENST00000893797
resolver
enst
ENST00000893798
resolver
enst
ENST00000893799
resolver
enst
ENST00000893800
resolver
enst
ENST00000893801
resolver
enst
ENST00000893802
resolver
enst
ENST00000893803
resolver
enst
ENST00000893804
resolver
enst
ENST00000893805
resolver
enst
ENST00000893806
resolver
enst
ENST00000893807
resolver
enst
ENST00000893808
resolver
enst
ENST00000893809
resolver
enst
ENST00000893810
resolver
enst
ENST00000893811
resolver
enst
ENST00000893812
resolver
enst
ENST00000948271
resolver
enst
ENST00000948272
resolver
genesymbol
TMEM100
resolver
hgnc
HGNC:25607
resolver
uniprot
D3DTY7
resolver
uniprot
I3L214
resolver
uniprot
Q96FZ0
resolver
uniprot_entry
TM100_HUMAN
resolver
uniprot_sec
D3DTY7
resolver
uniprot_sec
I3L214
resolver
uniprot_sec
Q96FZ0
resolver
amino_acid_sequence
MTEEPIKEILGAPKAHMAATMEKSPKSEVVITTVPLVSEIQLMAATGGTELSCYRCIIPFAVVVFIAGIVVTAVAYSFNSHGSIISIFGLVVLSSGLFLLASSALCWKVRQRSKKAKRRESQTALVANQRSLFA
uniprot
proteins
function
FUNCTION: Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex. {ECO:0000250|UniProtKB:Q9CQG9}.
uniprot
proteins
mass_dalton
14386
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
22783020
uniprot
proteins
pubmed
23485812
uniprot
proteins
sequence_length
134
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Perikaryon. Cytoplasm, perinuclear region. Endoplasmic reticulum. Note=Colocalized with HSPA5 in the endoplasmic reticulum (ER). Enriched in ER microsome. Colocalized with BMP4 in neural cell bodies and neural fibers of the enteric nervous system.
uniprot
proteins
transmembrane_region
TRANSMEM 56..76; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 84..104; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins