THAP4
entrez
51078
canonical
uniprot
Q8WY91
canonical
ensembl
ENSG00000176946
resolver
ensp
ENSP00000385006
resolver
ensp
ENSP00000385931
resolver
ensp
ENSP00000533304
resolver
genesymbol
THAP4
resolver
hgnc
HGNC:23187
resolver
uniprot
Q53NU7
resolver
uniprot
Q6GRN0
resolver
uniprot
Q6IPJ3
resolver
uniprot
Q9NW26
resolver
uniprot
Q9Y325
resolver
uniprot_entry
THAP4_HUMAN
resolver
uniprot_sec
Q53NU7
resolver
uniprot_sec
Q6GRN0
resolver
uniprot_sec
Q6IPJ3
resolver
uniprot_sec
Q9NW26
resolver
uniprot_sec
Q9Y325
resolver
amino_acid_sequence
MVICCAAVNCSNRQGKGEKRAVSFHRFPLKDSKRLIQWLKAVQRDNWTPTKYSFLCSEHFTKDSFSKRLEDQHRLLKPTAVPSIFHLTEKKRGAGGHGRTRRKDASKATGGVRGHSSAATSRGAAGWSPSSSGNPMAKPESRRLKQAALQGEATPRAAQEAASQEQAQQALERTPGDGLATMVAGSQGKAEASATDAGDESATSSIEGGVTDKSGISMDDFTPPGSGACKFIGSLHSYSFSSKHTRERPSVPREPIDRKRLKKDVEPSCSGSSLGPDKGLAQSPPSSSLTATPQKPSQSPSAPPADVTPKPATEAVQSEHSDASPMSINEVILSASGACKLIDSLHSYCFSSRQNKSQVCCLREQVEKKNGELKSLRQRVSRSDSQVRKLQEKLDELRRVSVPYPSSLLSPSREPPKMNPVVEPLSWMLGTWLSDPPGAGTYPTLQPFQYLEEVHISHVGQPMLNFSFNSFHPDTRKPMHRECGFIRLKPDTNKVAFVSAQNTGVVEVEEGEVNGQELCIASHSIARISFAKEPHVEQITRKFRLNSEGKLEQTVSMATTTQPMTQHLHVTYKKVTP
uniprot
proteins
ec_number
5.99.-.-
uniprot
proteins
function
FUNCTION: Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo, possibly modulating the transcriptional activity residing in the N-terminal region. {ECO:0000269|PubMed:30524950, ECO:0000269|PubMed:32295384}.
uniprot
proteins
mass_dalton
62890
uniprot
proteins
pathway_participation
PATHWAY: Nitrogen metabolism. {ECO:0000305|PubMed:30524950}.
uniprot
proteins
protein_family
Nitrobindin family
uniprot
proteins
pubmed
10810093
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
21387410
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
30524950
uniprot
proteins
pubmed
32295384
uniprot
proteins
sequence_length
577
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Localizes mainly in the cytoplasm and partially in the nucleus. {ECO:0000269|PubMed:32295384}.
uniprot
proteins