Eya2
entrez
14049
canonical
uniprot
O08575
canonical
ensembl
ENSMUSG00000017897
resolver
ensp
ENSMUSP00000066244
resolver
ensp
ENSMUSP00000085455
resolver
ensp
ENSMUSP00000197679
resolver
ensp
ENSMUSP00000197686
resolver
genesymbol
Eya2
resolver
genesymbol_syn
Eab1
resolver
uniprot
A2A5S4
resolver
uniprot
P97925
resolver
uniprot
Q3UR62
resolver
uniprot
Q3UV00
resolver
uniprot
Q811N7
resolver
uniprot_entry
EYA2_MOUSE
resolver
uniprot_entry
Q3UR62_MOUSE
resolver
uniprot_entry
Q3UV00_MOUSE
resolver
uniprot_entry
Q811N7_MOUSE
resolver
uniprot_sec
A2A5S4
resolver
uniprot_sec
P97925
resolver
amino_acid_sequence
MLEVVTSPSLATSSDWSEHGAAVGTLSDREGIAKSAALSVPQLFVKSHPRVPPGQSSTAMAAYGQTQYSTGIQQAPPYTAYPTPAQAYGIPPYSIKTEDSLNHSPSQSGFLSYGPSFSTAPAGQSPYTYPVHSTAGLYQGANGLTNTAGFGSVHQDYPSYPSFSQNQYPQYFSPSYNPPYVPASSLCSSPLSTSTYVLQEAPHNVPSQSSESLAGDYNTHNGPSTPAKEGDTERPHRASDGKLRGRSKRNSDPSPAGDNEIERVFVWDLDETIIIFHSLLTGTFASRYGKDTTTSVRIGLMMEEMIFNLADTHLFFNDLEDCDQIHVDDVSSDDNGQDLSTYNFSTDGFHSTAPGASLCLGTGVHGGVDWMRKLAFRYRRVKEMYNTYRNNVGGLIGAPKRETWLQLRAELEALTDLWLTHSLKALNLINSRPNCVNVLVTTTQLIPALAKVLLYGLGSVFPIENIYSATKTGKESCFERIMQRFGRKAVYIVIGDGVEEEQGAKKHNMPFWRISCHADLEALRHALELEYL
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5 (PubMed:10490620, PubMed:17098221). Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis (By similarity). Plays an important role in hypaxial muscle development together with SIX1 and DACH2; in this it is functionally redundant with EYA1 (By similarity). {ECO:0000250|UniProtKB:O00167, ECO:0000269|PubMed:10490620, ECO:0000269|PubMed:17098221}.
uniprot
proteins
mass_dalton
58246
uniprot
proteins
protein_family
EYA family
uniprot
proteins
protein_family
HAD-like hydrolase superfamily
uniprot
proteins
pubmed
10490620
uniprot
proteins
pubmed
11978764
uniprot
proteins
pubmed
14628052
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16476741
uniprot
proteins
pubmed
17098221
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
9006082
uniprot
proteins
pubmed
9049631
uniprot
proteins
pubmed
9195991
uniprot
proteins
sequence_length
532
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10490620}. Nucleus {ECO:0000269|PubMed:10490620}. Note=Retained in the cytoplasm via interaction with GNAZ and GNAI2 (By similarity). Interaction with SIX1, SIX2, SIX4 or SIX5 is required for translocation to the nucleus. {ECO:0000250|UniProtKB:O00167}.
uniprot
proteins