Pim2
entrez
18715
canonical
uniprot
Q62070
canonical
ensembl
ENSMUSG00000031155
resolver
ensp
ENSMUSP00000033495
resolver
genesymbol
Pim2
resolver
genesymbol_syn
Pim-2
resolver
uniprot
A2AER1
resolver
uniprot
Q62071
resolver
uniprot
Q62072
resolver
uniprot
Q8R1Z0
resolver
uniprot
Q8R2P0
resolver
uniprot_entry
PIM2_MOUSE
resolver
uniprot_entry
Q8R1Z0_MOUSE
resolver
uniprot_sec
A2AER1
resolver
uniprot_sec
Q62071
resolver
uniprot_sec
Q62072
resolver
uniprot_sec
Q8R2P0
resolver
amino_acid_sequence
MARATNLNAAPSAGASGPPDSLPSTLAPPSPGSPAALPRASTPCGLSGFSGLNIRSTSSMLTKPLQGHPSPPVTPTQPPGGKDRAAFEAEYRLGPLLGKGGFGTVFAGHRVTDRRQVAIKVISRNRVLGWSTVSDSVTCPLEVALLWKVGEGNGHPGVIRLLDWFETPEGFMLVLERPMPAQDLFDYITEKGPLGESCSRSFFTQVVAAVQHCHARGVVHRDIKDENILIDLCRGSIKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGVLLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPCSRPSLEEILLDPWMQSPAEEKPINSSKGSPTPLPWSLLP
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression, the regulation of cap-dependent protein translation and through survival signaling by phosphorylation of a pro-apoptotic protein, BAD. Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM2 might explain partly the strong synergism between these 2 oncogenes in tumorigenesis. Regulates cap-dependent protein translation in a mammalian target of rapamycin complex 1 (mTORC1)-independent manner and in parallel to the PI3K-Akt pathway. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Promotes cell survival in response to a variety of proliferative signals via positive regulation of the I-kappa-B kinase/NF-kappa-B cascade; this process requires phosphorylation of MAP3K8/COT. Promotes growth factor-independent proliferation by phosphorylation of cell cycle factors such as CDKN1A and CDKN1B. Involved in the positive regulation of chondrocyte survival and autophagy in the epiphyseal growth plate. {ECO:0000269|PubMed:12869584, ECO:0000269|PubMed:12954615, ECO:0000269|PubMed:15199164, ECO:0000269|PubMed:15548703, ECO:0000269|PubMed:15705789, ECO:0000269|PubMed:17476689, ECO:0000269|PubMed:18438430, ECO:0000269|PubMed:9294606}.
uniprot
proteins
mass_dalton
40060
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. {ECO:0000269|PubMed:12869584, ECO:0000269|PubMed:12954615, ECO:0000269|PubMed:15548703}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
PIM subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
12869584
uniprot
proteins
pubmed
12954615
uniprot
proteins
pubmed
15199164
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15548703
uniprot
proteins
pubmed
15642745
uniprot
proteins
pubmed
15705789
uniprot
proteins
pubmed
17476689
uniprot
proteins
pubmed
18438430
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
7781606
uniprot
proteins
pubmed
9294606
uniprot
proteins
sequence_length
370
uniprot
proteins