Trpv5
entrez
116469
canonical
uniprot
Q9JIP0
canonical
ensembl
ENSRNOG00000015394
resolver
ensembl
ENSRNOG00055031046
resolver
ensembl
ENSRNOG00060007584
resolver
ensembl
ENSRNOG00065015961
resolver
ensp
ENSRNOP00000020975
resolver
ensp
ENSRNOP00000046276
resolver
genesymbol
Trpv5
resolver
genesymbol_syn
Cat2
resolver
genesymbol_syn
Ecac
resolver
genesymbol_syn
Ecac1
resolver
uniprot
Q5UC98
resolver
uniprot
Q9JJL2
resolver
uniprot_entry
TRPV5_RAT
resolver
uniprot_sec
Q5UC98
resolver
uniprot_sec
Q9JJL2
resolver
activity_regulation
ACTIVITY REGULATION: Activated by WNK3. {ECO:0000250|UniProtKB:Q9NQA5}.
uniprot
proteins
amino_acid_sequence
MGVKKPWIQLQKRLNWWVREQDWNQHVDQLHMLQQKSIWESPLLRAAKENDMCTLKRLQHDQNCDFRQRGALGETALHVAALYDNLDAAIMLMETAPYLVTESTLCEPFVGQTALHIAIMNQNVNLVRALLARGASASARATGSAFHRSSHNLIYYGEHPLSFAACVGSEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQMYNLLLSHDGGDHLKSLELVPNNQGLTPFKLAGVEGNTVMFQHLMQKRKHIQWSLGPLTSSIYDLTEIDSWGEDLSFLELVVSSKKKEARQILEQTPVKELVSLKWKKYGQPYFCLLGMLYIFYMICFTTCCVYRPLKFRDANRTHVRDNTVLEQKPLQEAYVTYQDKVRLVGELVTVIGAVVILLIEIPDIFRVGASRYFGHTVLGGPFHVIIITYASLVLLIMVMRLTSMNGEVVPISMALVLGWCSVMYFSRGFQMLGPFTIMIQKMIFGDLLRFCWLMAMVILGFASAFYIIFQTEDPESLGEFSDYPTAMFSTFELFLTIIDGPANYSVDLPFMYHLTYFAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKMPRFLWPRSGICGCEYGLGDRWFLRVEHHQEQNPYRVLRYVEAFKSSDKEEVQEQLSEKQPSGTETGTLARGSVVLQTPPLSRTTSLSSNSHRGWEILRRNTLGHLNLGQDLGEGDGEEIYHF
uniprot
proteins
function
FUNCTION: Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine (PubMed:10875938). Required for normal Ca(2+) reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (By similarity). A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity). {ECO:0000250|UniProtKB:P69744, ECO:0000250|UniProtKB:Q9XSM3, ECO:0000269|PubMed:10875938}.
uniprot
proteins
mass_dalton
82454
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:Q9NQA5}.
uniprot
proteins
protein_family
TRPV5 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
protein_family
TrpV subfamily
uniprot
proteins
pubmed
10875938
uniprot
proteins
sequence_length
723
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10875938}; Multi-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000250|UniProtKB:Q9NQA5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NQA5}. Note=Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells (By similarity). The expression of the glycosylated form in the cell membrane is increased in the presence of WNK3 (By similarity). {ECO:0000250|UniProtKB:P69744, ECO:0000250|UniProtKB:Q9NQA5}.
uniprot
proteins
transmembrane_region
TRANSMEM 321..341; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9XSM3"; TRANSMEM 379..401; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9XSM3"; TRANSMEM 413..435; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9XSM3"; TRANSMEM 442..462; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9XSM3"; TRANSMEM 486..506; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9XSM3"; TRANSMEM 550..570; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9XSM3
uniprot
proteins