HTR3C
entrez
170572
canonical
uniprot
Q8WXA8
canonical
ensembl
ENSG00000178084
resolver
ensp
ENSP00000322617
resolver
enst
ENST00000318351
resolver
genesymbol
HTR3C
resolver
hgnc
HGNC:24003
resolver
uniprot
A2RRR5
resolver
uniprot_entry
5HT3C_HUMAN
resolver
uniprot_sec
A2RRR5
resolver
amino_acid_sequence
MEGGWPARQSALLCLTVSLLLQGRGDAFTINCSGFDQHGVDPAVFQAVFDRKAFRPFTNYSIPTRVNISFTLSAILGVDAQLQLLTSFLWMDLVWDNPFINWNPKECVGINKLTVLAENLWLPDIFIVESMDVDQTPSGLTAYISSEGRIKYDKPMRVTSICNLDIFYFPFDQQNCTFTFSSFLYTVDSMLLGMDKEVWEITDTSRKVIQTQGEWELLGINKATPKMSMGNNLYDQIMFYVAIRRRPSLYIINLLVPSSFLVAIDALSFYLPAESENRAPFKITLLLGYNVFLLMMNDLLPASGTPLISVYFALCLSLMVVSLLETVFITYLLHVATTQPPPMPRWLHSLLLHCTSPGRCCPTAPQKGNKGLGLTLTHLPGPKEPGELAGKKLGPRETEPDGGSGWTKTQLMELWVQFSHAMDTLLFRLYLLFMASSILTVIVLWNT
uniprot
proteins
function
FUNCTION: Forms serotonin (5-hydroxytryptamine/5-HT3)-activated cation-selective channel complexes, which when activated cause fast, depolarizing responses in neurons. {ECO:0000269|PubMed:17392525}.
uniprot
proteins
mass_dalton
50220
uniprot
proteins
protein_family
5-hydroxytryptamine receptor (TC 1.A.9.2) subfamily
uniprot
proteins
protein_family
HTR3C sub-subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
12801637
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17392525
uniprot
proteins
sequence_length
447
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000305|PubMed:17392525}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:17392525}; Multi-pass membrane protein {ECO:0000255}. Note=Presumably retained within the endoplasmic reticulum unless complexed with HTR3A. {ECO:0000269|PubMed:17392525}.
uniprot
proteins
transmembrane_region
TRANSMEM 249..269; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 283..303; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 307..329; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 425..445; /note="Helical; Name=4"; /evidence="ECO:0000255
uniprot
proteins