SH2D3C
entrez
10044
canonical
uniprot
Q8N5H7
canonical
ensembl
ENSG00000095370
resolver
ensp
ENSP00000317817
resolver
ensp
ENSP00000362373
resolver
ensp
ENSP00000362374
resolver
ensp
ENSP00000388536
resolver
ensp
ENSP00000394632
resolver
ensp
ENSP00000485866
resolver
genesymbol
SH2D3C
resolver
genesymbol_syn
NSP3
resolver
hgnc
HGNC:16884
resolver
uniprot
A8K5S8
resolver
uniprot
B4DG32
resolver
uniprot
E9PG48
resolver
uniprot
Q5HYE5
resolver
uniprot
Q5JU31
resolver
uniprot
Q6UY42
resolver
uniprot
Q8N6X3
resolver
uniprot
Q9Y2X5
resolver
uniprot_entry
B4DG32_HUMAN
resolver
uniprot_entry
SH2D3_HUMAN
resolver
uniprot_sec
A8K5S8
resolver
uniprot_sec
E9PG48
resolver
uniprot_sec
Q5HYE5
resolver
uniprot_sec
Q5JU31
resolver
uniprot_sec
Q6UY42
resolver
uniprot_sec
Q8N6X3
resolver
uniprot_sec
Q9Y2X5
resolver
amino_acid_sequence
MTEGTKKTSKKFKFFKFKGFGSLSNLPRSFTLRRSSASISRQSHLEPDTFEATQDDMVTVPKSPPAYARSSDMYSHMGTMPRPSIKKAQNSQAARQAQEAGPKPNLVPGGVPDPPGLEAAKEVMVKATGPLEDTPAMEPNPSAVEVDPIRKPEVPTGDVEEERPPRDVHSERAAGEPEAGSDYVKFSKEKYILDSSPEKLHKELEEELKLSSTDLRSHAWYHGRIPREVSETLVQRNGDFLIRDSLTSLGDYVLTCRWRNQALHFKINKVVVKAGESYTHIQYLFEQESFDHVPALVRYHVGSRKAVSEQSGAIIYCPVNRTFPLRYLEASYGLGQGSSKPASPVSPSGPKGSHMKRRSVTMTDGLTADKVTRSDGCPTSTSLPRPRDSIRSCALSMDQIPDLHSPMSPISESPSSPAYSTVTRVHAAPAAPSATALPASPVARRSSEPQLCPGSAPKTHGESDKGPHTSPSHTLGKASPSPSLSSYSDPDSGHYCQLQPPVRGSREWAATETSSQQARSYGERLKELSENGAPEGDWGKTFTVPIVEVTSSFNPATFQSLLIPRDNRPLEVGLLRKVKELLAEVDARTLARHVTKVDCLVARILGVTKEMQTLMGVRWGMELLTLPHGRQLRLDLLERFHTMSIMLAVDILGCTGSAEERAALLHKTIQLAAELRGTMGNMFSFAAVMGALDMAQISRLEQTWVTLRQRHTEGAILYEKKLKPFLKSLNEGKEGPPLSNTTFPHVLPLITLLECDSAPPEGPEPWGSTEHGVEVVLAHLEAARTVAHHGGLYHTNAEVKLQGFQARPELLEVFSTEFQMRLLWGSQGASSSQARRYEKFDKVLTALSHKLEPAVRSSEL
uniprot
proteins
function
FUNCTION: Acts as an adapter protein that mediates cell signaling pathways involved in cellular functions such as cell adhesion and migration, tissue organization, and the regulation of the immune response (PubMed:12432078, PubMed:20881139). Plays a role in integrin-mediated cell adhesion through BCAR1-CRK-RAPGEF1 signaling and activation of the small GTPase RAP1 (PubMed:12432078). Promotes cell migration and invasion through the extracellular matrix (PubMed:20881139). Required for marginal zone B-cell development and thymus-independent type 2 immune responses (By similarity). Mediates migration and adhesion of B cells in the splenic marginal zone via promoting hyperphosphorylation of NEDD9/CASL (By similarity). Plays a role in CXCL13-induced chemotaxis of B-cells (By similarity). Plays a role in the migration of olfactory sensory neurons (OSNs) into the forebrain and the innervation of the olfactory bulb by the OSN axons during development (By similarity). Required for the efficient tyrosine phosphorylation of BCAR1 in OSN axons (By similarity). {ECO:0000250|UniProtKB:Q9QZS8, ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:20881139}.; FUNCTION: [Isoform 1]: Important regulator of chemokine-induced, integrin-mediated T lymphocyte adhesion and migration, acting upstream of RAP1 (By similarity). Required for tissue-specific adhesion of T lymphocytes to peripheral tissues (By similarity). Required for basal and CXCL2 stimulated serine-threonine phosphorylation of NEDD9 (By similarity). May be involved in the regulation of T-cell receptor-mediated IL2 production through the activation of the JNK pathway in T-cells (By similarity). {ECO:0000250|UniProtKB:Q9QZS8}.; FUNCTION: [Isoform 2]: May be involved in the BCAR1/CAS-mediated JNK activation pathway. {ECO:0000250|UniProtKB:Q9QZS8}.
uniprot
proteins
mass_dalton
94411
uniprot
proteins
post_translational_modification
PTM: [Isoform 1]: Phosphorylated by MAPK/ERK upon T-cell receptor stimulation in T-cells. {ECO:0000250|UniProtKB:Q9QZS8}.
uniprot
proteins
pubmed
10187783
uniprot
proteins
pubmed
12432078
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17174122
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
20881139
uniprot
proteins
pubmed
22081014
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
860
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12432078, ECO:0000269|PubMed:17174122}. Cell membrane {ECO:0000269|PubMed:12432078}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9QZS8}. Cell projection, axon {ECO:0000250|UniProtKB:Q9QZS8}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q9QZS8}. Note=Associated with the membrane when EGF-stimulated (By similarity). Expressed at the cortical actin ring in B cells (By similarity). {ECO:0000250|UniProtKB:Q9QZS8}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:17174122}; Peripheral membrane protein {ECO:0000269|PubMed:17174122}.
uniprot
proteins