GGCT
entrez
79017
canonical
uniprot
O75223
canonical
ensembl
ENSG00000006625
resolver
ensp
ENSP00000005374
resolver
ensp
ENSP00000275428
resolver
ensp
ENSP00000386610
resolver
ensp
ENSP00000387235
resolver
genesymbol
GGCT
resolver
genesymbol_syn
C7orf24
resolver
genesymbol_syn
CRF21
resolver
hgnc
HGNC:21705
resolver
uniprot
B2RDN0
resolver
uniprot
B8ZZN4
resolver
uniprot
B8ZZR8
resolver
uniprot
Q9BS37
resolver
uniprot_entry
GGCT_HUMAN
resolver
uniprot_sec
B2RDN0
resolver
uniprot_sec
B8ZZN4
resolver
uniprot_sec
B8ZZR8
resolver
uniprot_sec
Q9BS37
resolver
amino_acid_sequence
MANSGCKDVTGPDEESFLYFAYGSNLLTERIHLRNPSAAFFCVARLQDFKLDFGNSQGKTSQTWHGGIATIFQSPGDEVWGVVWKMNKSNLNSLDEQEGVKSGMYVVIEVKVATQEGKEITCRSYLMTNYESAPPSPQYKKIICMGAKENGLPLEYQEKLKAIEPNDYTGKVSEEIEDIIKKGETQTL
uniprot
proteins
ec_number
4.3.2.9
uniprot
proteins
function
FUNCTION: Catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides and may play a significant role in glutathione homeostasis (PubMed:18515354). Induces release of cytochrome c from mitochondria with resultant induction of apoptosis (PubMed:16765912). {ECO:0000269|PubMed:16765912, ECO:0000269|PubMed:18515354}.
uniprot
proteins
mass_dalton
21008
uniprot
proteins
mutagenesis
MUTAGEN 23; /note="G->A: Marked decrease in catalytic efficiency."; /evidence="ECO:0000269|PubMed:18515354"; MUTAGEN 98; /note="E->A,Q: Abolishes activity without altering structure."; /evidence="ECO:0000269|PubMed:18515354"; MUTAGEN 105; /note="Y->F: Marked decrease in catalytic efficiency and specific activity."; /evidence="ECO:0000269|PubMed:18515354"; MUTAGEN 125; /note="Y->F: Little or no change in reaction kinetics."; /evidence="ECO:0000269|PubMed:18515354
uniprot
proteins
protein_family
Gamma-glutamylcyclotransferase family
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16765912
uniprot
proteins
pubmed
17932939
uniprot
proteins
pubmed
18515354
uniprot
proteins
pubmed
21269460
uniprot
proteins
sequence_length
188
uniprot
proteins