OST4
entrez
100128731
canonical
uniprot
P0C6T2
canonical
ensembl
ENSG00000228474
resolver
ensp
ENSP00000454411
resolver
ensp
ENSP00000455716
resolver
ensp
ENSP00000457935
resolver
ensp
ENSP00000559917
resolver
ensp
ENSP00000559918
resolver
ensp
ENSP00000559919
resolver
ensp
ENSP00000599738
resolver
ensp
ENSP00000599739
resolver
ensp
ENSP00000599740
resolver
enst
ENST00000429985
resolver
enst
ENST00000447619
resolver
enst
ENST00000456793
resolver
enst
ENST00000889858
resolver
enst
ENST00000889859
resolver
enst
ENST00000889860
resolver
enst
ENST00000929679
resolver
enst
ENST00000929680
resolver
enst
ENST00000929681
resolver
genesymbol
OST4
resolver
hgnc
HGNC:32483
resolver
uniprot_entry
OST4_HUMAN
resolver
amino_acid_sequence
MITDVQLAIFANMLGVSLFLLVVLYHYVAVNNPKKQE
uniprot
proteins
function
FUNCTION: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Specifically involved in maintaining stability of STT3A-containing OST complexes. {ECO:0000269|PubMed:23606741, ECO:0000269|PubMed:31831667}.
uniprot
proteins
mass_dalton
4193
uniprot
proteins
mutagenesis
MUTAGEN 23; /note="V->K: Decreases interaction with STT3A, STT3B and RPN1."; /evidence="ECO:0000269|PubMed:23606741
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:31831667}.
uniprot
proteins
protein_family
OST4 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
21609714
uniprot
proteins
pubmed
23606741
uniprot
proteins
pubmed
31831667
uniprot
proteins
pubmed
36697828
uniprot
proteins
pubmed
38670073
uniprot
proteins
sequence_length
37
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000305|PubMed:23606741}. Endoplasmic reticulum membrane; Single-pass type III membrane protein {ECO:0000305}. Note=The single transmembrane helix has a kink in the middle of the transmembrane span.
uniprot
proteins
transmembrane_region
TRANSMEM 5..25; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins