P2RY4
entrez
5030
canonical
uniprot
P51582
canonical
ensembl
ENSG00000186912
resolver
ensp
ENSP00000363643
resolver
enst
ENST00000374519
resolver
genesymbol
P2RY4
resolver
genesymbol_syn
NRU
resolver
hgnc
HGNC:8542
resolver
uniprot
Q4VBB7
resolver
uniprot
Q4VBB8
resolver
uniprot
Q502W2
resolver
uniprot
Q5JT22
resolver
uniprot_entry
P2RY4_HUMAN
resolver
uniprot_sec
Q4VBB7
resolver
uniprot_sec
Q4VBB8
resolver
uniprot_sec
Q502W2
resolver
uniprot_sec
Q5JT22
resolver
amino_acid_sequence
MASTESSLLRSLGLSPGPGSSEVELDCWFDEDFKFILLPVSYAVVFVLGLGLNAPTLWLFIFRLRPWDATATYMFHLALSDTLYVLSLPTLIYYYAAHNHWPFGTEICKFVRFLFYWNLYCSVLFLTCISVHRYLGICHPLRALRWGRPRLAGLLCLAVWLVVAGCLVPNLFFVTTSNKGTTVLCHDTTRPEEFDHYVHFSSAVMGLLFGVPCLVTLVCYGLMARRLYQPLPGSAQSSSRLRSLRTIAVVLTVFAVCFVPFHITRTIYYLARLLEADCRVLNIVNVVYKVTRPLASANSCLDPVLYLLTGDKYRRQLRQLCGGGKPQPRTAASSLALVSLPEDSSCRWAATPQDSSCSTPRADRL
uniprot
proteins
function
FUNCTION: Receptor for UTP and UDP coupled to G proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP.
uniprot
proteins
mass_dalton
40963
uniprot
proteins
mutagenesis
MUTAGEN 243; /note="S->A: No effect."; /evidence="ECO:0000269|PubMed:11114308"; MUTAGEN 333..365; /note="Missing: Abolishes agonist-induced phosphorylation. Prevents agonist-induced desensitization and loss of cell surface receptors."; MUTAGEN 333..359; /note="SSLALVSLPEDSSCRWAATPQDSSCST->AALALVALPEDAACRWAAAPQDAACAA: Greatly reduces agonist-induced desensitization and loss of cell surface receptors."; MUTAGEN 333; /note="S->A: Greatly reduces agonist-induced desensitization and loss of cell surface receptors; when associated with A-334 and A-339."; /evidence="ECO:0000269|PubMed:11114308"; MUTAGEN 334; /note="S->A: Greatly reduces agonist-induced desensitization and loss of cell surface receptors; when associated with A-333 and A-339."; /evidence="ECO:0000269|PubMed:11114308"; MUTAGEN 339; /note="S->A: Greatly reduces agonist-induced desensitization and loss of cell surface receptors; when associated with A-333 and A-334."; /evidence="ECO:0000269|PubMed:11114308"; MUTAGEN 344..365; /note="Missing: No effect on agonist-induced phosphorylation, no functional effect."; MUTAGEN 356..365; /note="Missing: No functional effect.
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Ser-333 and Ser-334 is a key step in agonist-dependent desensitization and loss of surface P2RY4. This phosphorylation does not involve PKC, nor other calcium activated kinases. {ECO:0000269|PubMed:11114308}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11114308
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
8537335
uniprot
proteins
pubmed
8537336
uniprot
proteins
pubmed
8617367
uniprot
proteins
sequence_length
365
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 35..61; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 73..95; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 113..131; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 155..174; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 197..222; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 247..269; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 288..309; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins