Tacr1
entrez
24807
canonical
uniprot
P14600
canonical
ensembl
ENSRNOG00000005853
resolver
ensembl
ENSRNOG00055012086
resolver
ensembl
ENSRNOG00060002187
resolver
ensembl
ENSRNOG00065016627
resolver
ensp
ENSRNOP00000007984
resolver
ensp
ENSRNOP00055016542
resolver
ensp
ENSRNOP00060002332
resolver
ensp
ENSRNOP00065021821
resolver
enst
ENSRNOT00000007984
resolver
enst
ENSRNOT00055020541
resolver
enst
ENSRNOT00060003407
resolver
enst
ENSRNOT00065027700
resolver
genesymbol
Tacr1
resolver
genesymbol_syn
Tac1r
resolver
uniprot_entry
NK1R_RAT
resolver
amino_acid_sequence
MDNVLPMDSDLFPNISTNTSESNQFVQPTWQIVLWAAAYTVIVVTSVVGNVVVIWIILAHKRMRTVTNYFLVNLAFAEACMAAFNTVVNFTYAVHNVWYYGLFYCKFHNFFPIAALFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVIFVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNRTYEKAYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHVFFLLPYINPDLYLKKFIQQVYLASMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQSSVYKVSRLETTISTVVGAHEEEPEEGPKATPSSLDLTSNGSSRSNSKTMTESSSFYSNMLA
uniprot
proteins
function
FUNCTION: Receptor for the tachykinin substance P, also able to bind and respond to tachynins neurokinin A/substance K and neurokinin B/neuromedin-K (PubMed:2478537, PubMed:2154852, PubMed:1370820). The rank order of affinity of this receptor to tachykinins is: substance P > neurokinin A/substance K > neurokinin B/neuromedin-K (PubMed:2478537, PubMed:1370820). Substance P binding to its receptor triggers G protein-coupled receptor signaling via activation of phosphatidylinositol hydrolysis by phospholipase C (PubMed:1370820). Substance P binding also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP) (PubMed:1370820). {ECO:0000269|PubMed:1370820, ECO:0000269|PubMed:2154852, ECO:0000269|PubMed:2478537}.
uniprot
proteins
mass_dalton
46366
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
1370820
uniprot
proteins
pubmed
1705552
uniprot
proteins
pubmed
2154852
uniprot
proteins
pubmed
2478537
uniprot
proteins
pubmed
7545030
uniprot
proteins
sequence_length
407
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7545030}; Multi-pass membrane protein {ECO:0000255}. Early endosome {ECO:0000269|PubMed:7545030}. Note=After signaling cascade initiation, substance P binding results in receptor internalization and localization to early endosomes, followed by receptor recycling to the cell surface. {ECO:0000269|PubMed:7545030}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..54; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 65..86; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 107..128; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 149..169; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 195..219; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 249..270; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 284..308; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins