Psmb8
entrez
16913
canonical
uniprot
P28063
canonical
ensembl
ENSMUSG00000024338
resolver
ensp
ENSMUSP00000025196
resolver
enst
ENSMUST00000025196
resolver
genesymbol
Psmb8
resolver
genesymbol_syn
Lmp7
resolver
genesymbol_syn
Mc13
resolver
uniprot
Q3UK42
resolver
uniprot
Q64300
resolver
uniprot
Q792S8
resolver
uniprot
Q7TMX9
resolver
uniprot
Q91VH7
resolver
uniprot_entry
PSB8_MOUSE
resolver
uniprot_sec
Q3UK42
resolver
uniprot_sec
Q64300
resolver
uniprot_sec
Q792S8
resolver
uniprot_sec
Q7TMX9
resolver
uniprot_sec
Q91VH7
resolver
amino_acid_sequence
MALLDLCGAARGQRPEWAALDAGSGGRSDPGHYSFSAQAPELALPRGMQPTAFLRSFGGDQERNVQIEMAHGTTTLAFKFQHGVIVAVDSRATAGSYISSLRMNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMLQYRGMGLSMGSMICGWDKKGPGLYYVDDNGTRLSGQMFSTGSGNTYAYGVMDSGYRQDLSPEEAYDLGRRAIAYATHRDNYSGGVVNMYHMKEDGWVKVESSDVSDLLYKYGEAAL
uniprot
proteins
ec_number
3.4.25.1
uniprot
proteins
function
FUNCTION: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity. This subunit is involved in antigen processing to generate class I binding peptides. May participate in the inflammatory response pathway. Required for adipocyte differentiation (PubMed:21881205, PubMed:22341445, PubMed:8066463). May be involved in the generation of spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein (By similarity). {ECO:0000250|UniProtKB:P28062, ECO:0000269|PubMed:21881205, ECO:0000269|PubMed:22341445, ECO:0000269|PubMed:8066463}.
uniprot
proteins
mass_dalton
30260
uniprot
proteins
post_translational_modification
PTM: Autocleaved. The resulting N-terminal Thr residue of the mature subunit is responsible for the nucleophile proteolytic activity. {ECO:0000250|UniProtKB:O35955}.
uniprot
proteins
protein_family
Peptidase T1B family
uniprot
proteins
pubmed
15371230
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15907481
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1633842
uniprot
proteins
pubmed
16452686
uniprot
proteins
pubmed
16857966
uniprot
proteins
pubmed
17142736
uniprot
proteins
pubmed
19525961
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21881205
uniprot
proteins
pubmed
22341445
uniprot
proteins
pubmed
23706739
uniprot
proteins
pubmed
8066463
uniprot
proteins
pubmed
8344725
uniprot
proteins
pubmed
8406612
uniprot
proteins
pubmed
8854085
uniprot
proteins
sequence_length
276
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00809}. Nucleus {ECO:0000250}.
uniprot
proteins