Steap3
entrez
68428
canonical
uniprot
Q8CI59
canonical
ensembl
ENSMUSG00000026389
resolver
ensp
ENSMUSP00000108258
resolver
ensp
ENSMUSP00000108259
resolver
ensp
ENSMUSP00000108260
resolver
ensp
ENSMUSP00000108262
resolver
enst
ENSMUST00000112639
resolver
enst
ENSMUST00000112640
resolver
enst
ENSMUST00000112641
resolver
enst
ENSMUST00000112643
resolver
genesymbol
Steap3
resolver
genesymbol_syn
Tsap6
resolver
uniprot
A0A0R4J1G9
resolver
uniprot
E9QN92
resolver
uniprot
Q3TKE4
resolver
uniprot
Q80ZF3
resolver
uniprot
Q8C5F0
resolver
uniprot
Q924Z1
resolver
uniprot_entry
A0A0R4J1G9_MOUSE
resolver
uniprot_entry
E9QN92_MOUSE
resolver
uniprot_entry
STEA3_MOUSE
resolver
uniprot_sec
Q3TKE4
resolver
uniprot_sec
Q80ZF3
resolver
uniprot_sec
Q8C5F0
resolver
uniprot_sec
Q924Z1
resolver
amino_acid_sequence
MSGEMDKPLISRRLVDSDGSLAEVPKEAPKVGILGSGDFARSLATRLVGSGFSVVVGSRNPKRTAGLFPSLAQVTFQEEAVSSPEVIFVAVFREHYSSLCSLADQLAGKILVDVSNPTEKEHLQHRQSNAEYLASLFPACTVVKAFNVISAWALQAGPRDGNRQVLICSDQPEAKRTISEMARAMGFTPLDMGSLASAREVEAIPLRLLPSWKVPTLLALGLFVCFYTYNFIRDVLQPYIRKDENKFYKMPLSVVNTTLPCVAYVLLSLVYLPGVLAAALQLRRGTKYQRFPDWLDHWLQHRKQIGLLSFFFAMLHALYSFCLPLRRSHRYDLVNLAVKQVLANKSRLWVEEEVWRMEIYLSLGVLALGMLSLLAVTSLPSIANSLNWKEFSFVQSTLGFVALILSTMHTLTYGWTRAFEENHYKFYLPPTFTLTLLLPCVIILAKGLFLLPCLSRRLTKIRRGWEKDGAVKFMLPGDHTQGEKTSHV
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Steap3 are the cause of fragile-red phenotype characterized by hypochromic microcytic anemia. {ECO:0000269|PubMed:18955558}.
uniprot
proteins
ec_number
1.16.1.-
uniprot
proteins
function
FUNCTION: Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (PubMed:16227996, PubMed:16609065, PubMed:18955558). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (PubMed:16609065). Mediates efficient transferrin-dependent iron uptake in erythroid cells (PubMed:16227996). May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression (By similarity). Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP (By similarity). {ECO:0000250|UniProtKB:Q5RKL5, ECO:0000250|UniProtKB:Q658P3, ECO:0000250|UniProtKB:Q687X5, ECO:0000269|PubMed:16227996, ECO:0000269|PubMed:16609065, ECO:0000269|PubMed:18955558}.
uniprot
proteins
mass_dalton
54749
uniprot
proteins
mutagenesis
MUTAGEN 316; /note="H->L: Loss of ferric-chelate reductase activity."; /evidence="ECO:0000269|PubMed:16227996"; MUTAGEN 409; /note="H->L: Loss of ferric-chelate reductase activity."; /evidence="ECO:0000269|PubMed:16227996
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage occurs at multiple sites in a glycosylation-independent manner (By similarity). {ECO:0000250|UniProtKB:Q658P3}.; PTM: Glycosylated. {ECO:0000250|UniProtKB:Q658P3}.
uniprot
proteins
protein_family
STEAP family
uniprot
proteins
pubmed
12606722
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16227996
uniprot
proteins
pubmed
16609065
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18955558
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
488
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000269|PubMed:16227996, ECO:0000269|PubMed:18955558}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 208..228; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 259..279; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 305..325; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 359..379; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 391..411; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 434..454; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins