APAF1
entrez
317
canonical
uniprot
O14727
canonical
ensembl
ENSG00000120868
resolver
ensp
ENSP00000334558
resolver
ensp
ENSP00000349862
resolver
ensp
ENSP00000353059
resolver
ensp
ENSP00000448165
resolver
ensp
ENSP00000448449
resolver
genesymbol
APAF1
resolver
genesymbol_syn
KIAA0413
resolver
hgnc
HGNC:576
resolver
uniprot
B2RMX8
resolver
uniprot
O43297
resolver
uniprot
Q7Z438
resolver
uniprot
Q9BXZ6
resolver
uniprot
Q9UBZ5
resolver
uniprot
Q9UGN8
resolver
uniprot
Q9UGN9
resolver
uniprot
Q9UGP0
resolver
uniprot
Q9UJ58
resolver
uniprot
Q9UJ59
resolver
uniprot
Q9UJ60
resolver
uniprot
Q9UJ61
resolver
uniprot
Q9UJ62
resolver
uniprot
Q9UJ63
resolver
uniprot
Q9UJ64
resolver
uniprot
Q9UJ65
resolver
uniprot
Q9UJ66
resolver
uniprot
Q9UJ67
resolver
uniprot
Q9UNC9
resolver
uniprot_entry
APAF_HUMAN
resolver
uniprot_sec
B2RMX8
resolver
uniprot_sec
O43297
resolver
uniprot_sec
Q7Z438
resolver
uniprot_sec
Q9BXZ6
resolver
uniprot_sec
Q9UBZ5
resolver
uniprot_sec
Q9UGN8
resolver
uniprot_sec
Q9UGN9
resolver
uniprot_sec
Q9UGP0
resolver
uniprot_sec
Q9UJ58
resolver
uniprot_sec
Q9UJ59
resolver
uniprot_sec
Q9UJ60
resolver
uniprot_sec
Q9UJ61
resolver
uniprot_sec
Q9UJ62
resolver
uniprot_sec
Q9UJ63
resolver
uniprot_sec
Q9UJ64
resolver
uniprot_sec
Q9UJ65
resolver
uniprot_sec
Q9UJ66
resolver
uniprot_sec
Q9UJ67
resolver
uniprot_sec
Q9UNC9
resolver
amino_acid_sequence
MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE
uniprot
proteins
function
FUNCTION: Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis. {ECO:0000269|PubMed:10393175, ECO:0000269|PubMed:12804598}.
uniprot
proteins
mass_dalton
141840
uniprot
proteins
mutagenesis
MUTAGEN 160; /note="K->R: No association with APAF-1. No binding to pro-caspase-9."; /evidence="ECO:0000269|PubMed:10393175"; MUTAGEN 368; /note="M->L: Activation of pro-caspase-9 independent of cytochrome c. Increased ability to induce apoptosis."; /evidence="ECO:0000269|PubMed:10393175
uniprot
proteins
pubmed
10364241
uniprot
proteins
pubmed
10393175
uniprot
proteins
pubmed
10441496
uniprot
proteins
pubmed
10543941
uniprot
proteins
pubmed
10578182
uniprot
proteins
pubmed
11389439
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
12804598
uniprot
proteins
pubmed
15262985
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17244527
uniprot
proteins
pubmed
21371431
uniprot
proteins
pubmed
25716227
uniprot
proteins
pubmed
31498791
uniprot
proteins
pubmed
9267021
uniprot
proteins
pubmed
9455477
uniprot
proteins
pubmed
9651578
uniprot
proteins
sequence_length
1248
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12804598}.
uniprot
proteins