Sdcbp
entrez
53378
canonical
uniprot
O08992
canonical
ensembl
ENSMUSG00000028249
resolver
ensp
ENSMUSP00000029912
resolver
ensp
ENSMUSP00000100073
resolver
ensp
ENSMUSP00000206641
resolver
ensp
ENSMUSP00000206648
resolver
ensp
ENSMUSP00000206649
resolver
ensp
ENSMUSP00000206651
resolver
ensp
ENSMUSP00000206656
resolver
ensp
ENSMUSP00000206659
resolver
ensp
ENSMUSP00000206663
resolver
enst
ENSMUST00000029912
resolver
enst
ENSMUST00000103008
resolver
genesymbol
Sdcbp
resolver
uniprot
A2AKJ7
resolver
uniprot
F6U766
resolver
uniprot
Q3TMX0
resolver
uniprot
Q544P5
resolver
uniprot_entry
F6U766_MOUSE
resolver
uniprot_entry
Q3TMX0_MOUSE
resolver
uniprot_entry
SDCB1_MOUSE
resolver
uniprot_sec
A2AKJ7
resolver
uniprot_sec
Q544P5
resolver
amino_acid_sequence
MSLYPSLEDLKVDKVIQAQTAYSANPASQAFVLVDASAALPPDGNLYPKLYPELSQYMGLSLNEAEICESMPMVSGAPAQGQLVARPSSVNYMVAPVTGNDAGIRRAEIKQGIREVILCKDQDGKIGLRLKSIDNGIFVQLVQANSPASLVGLRFGDQVLQINGENCAGWSSDKAHKVLKQAFGEKITMTIRDRPFERTVTMHKDSSGHVGFIFKSGKITSIVKDSSAARNGLLTDHHICEINGQNVIGLKDAQIADILSTAGTVVTITIMPTFIFEHIIKRMAPSIMKSLMDHTIPEV
uniprot
proteins
function
FUNCTION: Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (By similarity). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (By similarity). {ECO:0000250|UniProtKB:O00560, ECO:0000269|PubMed:26539120}.
uniprot
proteins
mass_dalton
32379
uniprot
proteins
mutagenesis
MUTAGEN 4..5; /note="YP->AA: No loss of interaction with PDCD6IP. Loss of interaction with PDCD6IP; when associated with 46-A--A-47 and 50-A--A-51."; /evidence="ECO:0000269|PubMed:22660413"; MUTAGEN 47..48; /note="YP->AA: No loss of interaction with PDCD6IP. Loss of interaction with PDCD6IP; when associated with 4-A--A-5 and 51-A--A-52."; /evidence="ECO:0000269|PubMed:22660413"; MUTAGEN 51..52; /note="YP->AA: No loss of interaction with PDCD6IP. Loss of interaction with PDCD6IP; when associated with 4-A--A-5 and 47-A--A-48."; /evidence="ECO:0000269|PubMed:22660413
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues. {ECO:0000250}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22660413
uniprot
proteins
pubmed
25644602
uniprot
proteins
pubmed
26539120
uniprot
proteins
sequence_length
299
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000250|UniProtKB:O00560}. Cell junction, adherens junction {ECO:0000250|UniProtKB:O00560}. Cell membrane {ECO:0000250|UniProtKB:O00560}; Peripheral membrane protein {ECO:0000250|UniProtKB:O00560}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O00560}; Peripheral membrane protein {ECO:0000250|UniProtKB:O00560}. Nucleus {ECO:0000250|UniProtKB:O00560}. Melanosome {ECO:0000250|UniProtKB:O00560}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:O00560}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O00560}. Secreted, extracellular exosome {ECO:0000250|UniProtKB:O00560}. Membrane raft {ECO:0000250|UniProtKB:O00560}. Note=Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2) (By similarity). {ECO:0000250|UniProtKB:O00560}.
uniprot
proteins