Slc13a5
entrez
237831
canonical
uniprot
Q67BT3
canonical
ensembl
ENSMUSG00000020805
resolver
ensp
ENSMUSP00000021161
resolver
ensp
ENSMUSP00000237491
resolver
ensp
ENSMUSP00000237492
resolver
ensp
ENSMUSP00000237495
resolver
enst
ENSMUST00000021161
resolver
genesymbol
Slc13a5
resolver
genesymbol_syn
Nact
resolver
uniprot_entry
S13A5_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by Li(+). {ECO:0000269|PubMed:12826022}.
uniprot
proteins
amino_acid_sequence
MDSAKTCVTKFKSFAILLFTPILMLPLVILIPDKFARCAYVIVIMAVYWCTDVIPVAVTSLLPVLLFPLLKVLDSKQVCIQYMKDTNMLFLGSLIVAVAVERWKLHKRVALRMLLFVGTKPSRLMLGFMFVTAFLSMWISNTAATAMMIPIVEAMLQQMIAANTAVEASLGTLELLDKNKTSELPGSQVVFEDPNVQEQEDEETKNMYKAMHLCVCYSASIGGTATLTGTGPNVVLLGQMQELFPDSKDVLNYASWFGFAFPNMVMMLVLAWLWLQCLYMRHNLKKTCICCGEKKRDTEKIAYKVLNEEYQKLGSLSYPECNVLFCFTLLVILWFSRDPGFMPGWLSFAWVEGNTVHITDATVAIFVAILLFIIPSQKPKFNFSSQTEEERKTPFYPPALLDWKVAQEKVPWDIVLLLGGGFAMAKGCETSGLSKWMAAQMEPLRLVKPAVITLILSCLVAMTTECTSNVATTTLFLPIFASMARSIGIHPLYVMIPCTMSASLAFMLPVATPPNAIVFAYGHLRVVDMMKTGLIMNFVGILSVFLSVNTWGRAMFNLDNFPDWANSTSVNT
uniprot
proteins
function
FUNCTION: High-affinity sodium/citrate cotransporter that mediates citrate entry into cells, which is a critical participant of biochemical pathways (PubMed:14656221, PubMed:26324167, PubMed:35448538). May function in various metabolic processes in which citrate has a critical role such as energy production (Krebs cycle), fatty acid synthesis, cholesterol synthesis, glycolysis, and gluconeogenesis (PubMed:12826022). Transports citrate into the cell in a Na(+)-dependent manner, recognizing the trivalent form of citrate (physiological pH) rather than the divalent form (PubMed:12826022, PubMed:14656221, PubMed:26324167). Can recognizes succinate as a substrate, but its affinity for succinate is several fold lower than for citrate (PubMed:14656221, PubMed:26324167). The stoichiometry is probably 4 Na(+) for each carboxylate, irrespective of whether the translocated substrate is divalent or trivalent, rendering the process electrogenic (PubMed:14656221, PubMed:26324167). Involved in the regulation of citrate levels in the brain (PubMed:32682952). {ECO:0000269|PubMed:12826022, ECO:0000269|PubMed:14656221, ECO:0000269|PubMed:26324167, ECO:0000269|PubMed:32682952, ECO:0000269|PubMed:35448538}.
uniprot
proteins
mass_dalton
63823
uniprot
proteins
protein_family
NADC subfamily
uniprot
proteins
protein_family
SLC13A/DASS transporter (TC 2.A.47) family
uniprot
proteins
pubmed
12826022
uniprot
proteins
pubmed
14656221
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
26324167
uniprot
proteins
pubmed
32682952
uniprot
proteins
pubmed
35448538
uniprot
proteins
sequence_length
572
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q86YT5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q86YT5}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..28; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q86YT5"; TRANSMEM 34..49; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q86YT5"; TRANSMEM 56..69; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q86YT5"; TRANSMEM 75..117; /note="Discontinuously helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q86YT5"; TRANSMEM 206..243; /note="Discontinuously helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q86YT5"; TRANSMEM 253..279; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q86YT5"; TRANSMEM 319..336; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q86YT5"; TRANSMEM 360..372; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q86YT5"; TRANSMEM 403..439; /note="Discontinuously helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q86YT5"; TRANSMEM 491..521; /note="Discontinuously helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q86YT5"; TRANSMEM 527..555; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q86YT5
uniprot
proteins