MICAL2
entrez
9645
canonical
uniprot
O94851
canonical
ensembl
ENSG00000133816
resolver
ensp
ENSP00000256194
resolver
ensp
ENSP00000433965
resolver
ensp
ENSP00000494982
resolver
ensp
ENSP00000499778
resolver
ensp
ENSP00000502351
resolver
ensp
ENSP00000507067
resolver
ensp
ENSP00000516723
resolver
ensp
ENSP00000534379
resolver
ensp
ENSP00000617396
resolver
ensp
ENSP00000617407
resolver
ensp
ENSP00000617420
resolver
ensp
ENSP00000617425
resolver
genesymbol
MICAL2
resolver
genesymbol_syn
KIAA0750
resolver
genesymbol_syn
MICAL2PV1
resolver
genesymbol_syn
MICAL2PV2
resolver
genesymbol_syn
MICALCL
resolver
hgnc
HGNC:24693
resolver
uniprot
A0A2R8YFA9
resolver
uniprot
B4DGZ0
resolver
uniprot
B7Z849
resolver
uniprot
D3DQW5
resolver
uniprot
G3XAC8
resolver
uniprot
Q5KTR3
resolver
uniprot
Q5KTR4
resolver
uniprot
Q6ZW33
resolver
uniprot
Q7RTP7
resolver
uniprot
Q7Z3A8
resolver
uniprot
Q96JU6
resolver
uniprot_entry
MICA2_HUMAN
resolver
uniprot_sec
A0A2R8YFA9
resolver
uniprot_sec
B4DGZ0
resolver
uniprot_sec
B7Z849
resolver
uniprot_sec
D3DQW5
resolver
uniprot_sec
G3XAC8
resolver
uniprot_sec
Q5KTR3
resolver
uniprot_sec
Q5KTR4
resolver
uniprot_sec
Q6ZW33
resolver
uniprot_sec
Q7RTP7
resolver
uniprot_sec
Q7Z3A8
resolver
uniprot_sec
Q96JU6
resolver
activity_regulation
ACTIVITY REGULATION: Specifically inhibited by CCG-1423, a small molecule inhibitor of SRF:MKL1/MRTF-A-dependent transcription. {ECO:0000269|PubMed:24440334}.
uniprot
proteins
amino_acid_sequence
MGENEDEKQAQAGQVFENFVQASTCKGTLQAFNILTRHLDLDPLDHRNFYSKLKSKVTTWKAKALWYKLDKRGSHKEYKRGKSCTNTKCLIVGGGPCGLRTAIELAYLGAKVVVVEKRDSFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGSIDHISIRQLQLILFKVALMLGVEIHVNVEFVKVLEPPEDQENQKIGWRAEFLPTDHSLSEFEFDVIIGADGRRNTLEGFRRKEFRGKLAIAITANFINRNSTAEAKVEEISGVAFIFNQKFFQDLKEETGIDLENIVYYKDCTHYFVMTAKKQSLLDKGVIINDYIDTEMLLCAENVNQDNLLSYAREAADFATNYQLPSLDFAMNHYGQPDVAMFDFTCMYASENAALVRERQAHQLLVALVGDSLLEPFWPMGTGCARGFLAAFDTAWMVKSWNQGTPPLELLAERESLYRLLPQTTPENINKNFEQYTLDPGTRYPNLNSHCVRPHQVKHLYITKELEHYPLERLGSVRRSVNLSRKESDIRPSKLLTWCQQQTEGYQHVNVTDLTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTGKEMASAQEPDKLSMVMYLSKFYELFRGTPLRPVDSWRKNYGENADLSLAKSSISNNYLNLTFPRKRTPRVDGQTGENDMNKRRRKGFTNLDEPSNFSSRSLGSNQECGSSKEGGNQNKVKSMANQLLAKFEESTRNPSLMKQERRVSGIGKPVLCSSSGPPVHSCCPKPEEATPSPSPPLKRQFPSVVVTGHVLRELKQVSAGSECLSRPWRARAKSDLQLGGTENFATLPSTRPRAQALSGVLWRLQQVEEKILQKRAQNLANREFHTKNIKEKAAHLASMFGHGDFPQNKLLSKGLSHTHPPSPPSRLPSPDPAASSSPSTVDSASPARKEKKSPSGFHFHPSHLRTVHPQLTVGKVSSGIGAAAEVLVNLYMNDHRPKAQATSPDLESMRKSFPLNLGGSDTCYFCKKRVYVMERLSAEGHFFHRECFRCSICATTLRLAAYTFDCDEGKFYCKPHFIHCKTNSKQRKRRAELKQQREEEATWQEQEAPRRDTPTESSCAVAAIGTLEGSPPDEPTSPKRPKSISEPQHSDAEGDAASPLPSEWTSVRISPGEEAAGQDVLAVRVLVTSEDSSSDTESDYGGSEGSHTEPCEEKPWRPGSPHLPHTSLGEALSRAVSPQCPEEPRAVHAALQRANSFQSPTPSKYQNWRREFWWSLTPVNKRTMSPPKDPSPSLPLPSSSSHSSSPPSSSSTSVSGNAPDGSSPPQMTASEPLSQVSRGHPSPPTPNFRRRAVAQGAPREIPLYLPHHPKPEWAEYCLVSPGEDGLSDPAEMTSDECQPAEAPLGDIGSNHRDPHPIWGKDRSWTGQELSPLAGEDREKGSTGARKEEEGGPVLVKEKLGLKKLVLTQEQKTMLLDWNDSIPESVHLKAGERISQKSAENGRGGRVLKPVRPLLLPRAAGEPLPTQRGAQEKMGTPAEQAQGERNVPPPKSPLRLIANAIRRSLEPLLSNSEGGKKAWAKQESKTLPAQACTRSFSLRKTNSNKDGDQHSPGRNQSSAFSPPDPALRTHSLPNRPSKVFPALRSPPCSKIEDVPTLLEKVSLQENFPDASKPPKKRISLFSSLRLKDKSFESFLQESRQRKDIRDLFGSPKRKVLPEDSAQALEKLLQPFKSTSLRQAAPPPPPPPPPPPPPPTAGGADSKNFPLRAQVTEASSSASSTSSSSADEEFDPQLSLQLKEKKTLRRRKKLEKAMKQLVKQEELKRLYKAQAIQRQLEEVEERQRASEIQGVRLEKALRGEADSGTQDEAQLLQEWFKLVLEKNKLMRYESELLIMAQELELEDHQSRLEQKLREKMLKEESQKDEKDLNEEQEVFTELMQVIEQRDKLVDSLEEQRIREKAEDQHFESFVFSRGCQLSRT
uniprot
proteins
ec_number
1.14.13.225
uniprot
proteins
function
FUNCTION: Methionine monooxygenase that promotes depolymerization of F-actin by mediating oxidation of residues 'Met-44' and 'Met-47' on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization (PubMed:24440334, PubMed:29343822). Regulates the disassembly of branched actin networks also by oxidizing ARP3B-containing ARP2/3 complexes leading to ARP3B dissociation from the network (PubMed:34106209). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA (PubMed:24440334). {ECO:0000269|PubMed:24440334, ECO:0000269|PubMed:29343822, ECO:0000269|PubMed:34106209}.
uniprot
proteins
mass_dalton
219061
uniprot
proteins
mutagenesis
MUTAGEN 95; /note="G->V: Blocks FAD binding and abolishes catalytic activity."; /evidence="ECO:0000269|PubMed:24440334"; MUTAGEN 677..681; /note="KRRRK->AAAAA: In MICAL-2NLSMut; abolishes nuclear localization."; /evidence="ECO:0000269|PubMed:24440334
uniprot
proteins
protein_family
Mical family
uniprot
proteins
pubmed
12110185
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15694364
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16675569
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24440334
uniprot
proteins
pubmed
27552051
uniprot
proteins
pubmed
29343822
uniprot
proteins
pubmed
34106209
uniprot
proteins
pubmed
9872452
uniprot
proteins
sequence_length
1957
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24440334}. Cytoplasm {ECO:0000250|UniProtKB:Q8BML1}.
uniprot
proteins