CCNT1
entrez
904
canonical
uniprot
O60563
canonical
ensembl
ENSG00000129315
resolver
ensp
ENSP00000261900
resolver
ensp
ENSP00000481035
resolver
ensp
ENSP00000568609
resolver
genesymbol
CCNT1
resolver
hgnc
HGNC:1599
resolver
uniprot
A8K4M5
resolver
uniprot
A9XU13
resolver
uniprot
E7EX76
resolver
uniprot
O60581
resolver
uniprot_entry
A8K4M5_HUMAN
resolver
uniprot_entry
CCNT1_HUMAN
resolver
uniprot_sec
A9XU13
resolver
uniprot_sec
E7EX76
resolver
uniprot_sec
O60581
resolver
amino_acid_sequence
MEGERKNNNKRWYFTREQLENSPSRRFGVDPDKELSYRQQAANLLQDMGQRLNVSQLTINTAIVYMHRFYMIQSFTQFPGNSVAPAALFLAAKVEEQPKKLEHVIKVAHTCLHPQESLPDTRSEAYLQQVQDLVILESIILQTLGFELTIDHPHTHVVKCTQLVRASKDLAQTSYFMATNSLHLTTFSLQYTPPVVACVCIHLACKWSNWEIPVSTDGKHWWEYVDATVTLELLDELTHEFLQILEKTPNRLKRIWNWRACEAAKKTKADDRGTDEKTSEQTILNMISQSSSDTTIAGLMSMSTSTTSAVPSLPVSEESSSNLTSVEMLPGKRWLSSQPSFKLEPTQGHRTSENLALTGVDHSLPQDGSNAFISQKQNSKSVPSAKVSLKEYRAKHAEELAAQKRQLENMEANVKSQYAYAAQNLLSHHDSHSSVILKMPIEGSENPERPFLEKADKTALKMRIPVAGGDKAASSKPEEIKMRIKVHAAADKHNSVEDSVTKSREHKEKHKTHPSNHHHHHNHHSHKHSHSQLPVGTGNKRPGDPKHSSQTSNLAHKTYSLSSSFSSSSSTRKRGPSEETGGAVFDHPAKIAKSTKSSSLNFSFPSLPTMGQMPGHSSDTSGLSFSQPSCKTRVPHSKLDKGPTGANGHNTTQTIDYQDTVNMLHSLLSAQGVQPTQPTAFEFVRPYSDYLNPRSGGISSRSGNTDKPRPPPLPSEPPPPLPPLPK
uniprot
proteins
function
FUNCTION: Regulatory subunit of the cyclin-dependent kinase pair (CDK9/cyclin-T1) complex, also called positive transcription elongation factor B (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNA Pol II) (PubMed:16109376, PubMed:16109377, PubMed:30134174, PubMed:35393539). Required to activate the protein kinase activity of CDK9: acts by mediating formation of liquid-liquid phase separation (LLPS) that enhances binding of P-TEFb to the CTD of RNA Pol II (PubMed:29849146, PubMed:35393539). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:29849146, ECO:0000269|PubMed:30134174, ECO:0000269|PubMed:35393539}.; FUNCTION: (Microbial infection) In case of HIV or SIV infections, binds to the transactivation domain of the viral nuclear transcriptional activator, Tat, thereby increasing Tat's affinity for the transactivating response RNA element (TAR RNA). Serves as an essential cofactor for Tat, by promoting RNA Pol II activation, allowing transcription of viral genes. {ECO:0000269|PubMed:10329125, ECO:0000269|PubMed:10329126}.
uniprot
proteins
mass_dalton
80685
uniprot
proteins
mutagenesis
MUTAGEN 261; /note="C->Y: Loss of HIV-1 Tat transactivation."; /evidence="ECO:0000269|PubMed:10329126"; MUTAGEN 517..527; /note="HHHHHNHHSHK->AAAAANAASAKA: In mutant 9A; impaired formation of phase-separated liquid droplets, leading to decreased ability to activate CDK9."; /evidence="ECO:0000269|PubMed:29849146
uniprot
proteins
post_translational_modification
PTM: ADP-ribosylation on serine residues by PARP1 in response to DNA damage disrupts the phase separation activity of CCNT1, thereby preventing activation of CDK9. {ECO:0000269|PubMed:35393539}.
uniprot
proteins
protein_family
Cyclin C subfamily
uniprot
proteins
protein_family
Cyclin family
uniprot
proteins
pubmed
10329125
uniprot
proteins
pubmed
10329126
uniprot
proteins
pubmed
10364329
uniprot
proteins
pubmed
10393184
uniprot
proteins
pubmed
10913173
uniprot
proteins
pubmed
12065898
uniprot
proteins
pubmed
12944466
uniprot
proteins
pubmed
14972556
uniprot
proteins
pubmed
16109376
uniprot
proteins
pubmed
16109377
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17643375
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23033978
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24360279
uniprot
proteins
pubmed
27189267
uniprot
proteins
pubmed
27292648
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
29849146
uniprot
proteins
pubmed
30134174
uniprot
proteins
pubmed
34696162
uniprot
proteins
pubmed
35393539
uniprot
proteins
pubmed
9491887
uniprot
proteins
pubmed
9499409
uniprot
proteins
pubmed
9832504
uniprot
proteins
sequence_length
726
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12944466, ECO:0000269|PubMed:29849146}.
uniprot
proteins