Dhrs11
entrez
192970
canonical
uniprot
Q3U0B3
canonical
ensembl
ENSMUSG00000034449
resolver
ensp
ENSMUSP00000043467
resolver
enst
ENSMUST00000047560
resolver
genesymbol
Dhrs11
resolver
genesymbol_syn
Sdr24c1
resolver
uniprot
Q5SXB3
resolver
uniprot
Q8R249
resolver
uniprot_entry
DHR11_MOUSE
resolver
uniprot_sec
Q5SXB3
resolver
uniprot_sec
Q8R249
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by flavonoids including apigenin, luteolin, genistein, kaempferol and quercetin and also by carbenoxolone, zearalenone, glycyrrhetinic, curcumin and flufenamic acid. {ECO:0000250|UniProtKB:Q6UWP2}.
uniprot
proteins
amino_acid_sequence
MTRAGMERWRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKSAGYPGTLIPYRCDLSNEEDILSMFSAVRSQHSGVDICINNAGMARPDTLLSGSTSGWKDMFNVNVLALSICTREAYQSMKERNIDDGHIININSMCGHRVPPQSVIHFYSATKYAVTALTEGLRQELLEAQTHIRATCISPGLVETQFAFKLHDKDPGEAAATYEHIKCLRPEDVAEAVIYVLSTPPHVQVGDIQMRPTEQVT
uniprot
proteins
ec_number
1.1.1.270
uniprot
proteins
ec_number
1.1.1.62
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta-hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3beta-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May contribute to the metabolism of adrenal-derived androgen precursors. Reduces 11-keto-4-androstene-3,17-dione (11KA4) and 11-keto-5alpha-androstane-3,17-dione (11K-Adione) into potent androgens 11-ketotestosterone (11KT) and 11-ketodihydrotestosterone (11KDHT), respectively. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones. {ECO:0000250|UniProtKB:Q6UWP2}.
uniprot
proteins
mass_dalton
28274
uniprot
proteins
pathway_participation
PATHWAY: Steroid biosynthesis; estrogen biosynthesis. {ECO:0000250|UniProtKB:Q6UWP2}.
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
260
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
uniprot
proteins