Sbds
entrez
288615
canonical
uniprot
Q5RK30
canonical
ensembl
ENSRNOG00000000888
resolver
ensembl
ENSRNOG00055000232
resolver
ensembl
ENSRNOG00060010643
resolver
ensembl
ENSRNOG00065001596
resolver
ensp
ENSRNOP00000001190
resolver
ensp
ENSRNOP00055000277
resolver
ensp
ENSRNOP00060014030
resolver
ensp
ENSRNOP00065001491
resolver
enst
ENSRNOT00000001190
resolver
enst
ENSRNOT00055000391
resolver
enst
ENSRNOT00060018025
resolver
enst
ENSRNOT00065002137
resolver
genesymbol
Sbds
resolver
uniprot_entry
SBDS_RAT
resolver
amino_acid_sequence
MSIFTPTNQIRLTNVAVVRMKRGGKRFEIACYKNKVVGWRSGVEKDLDEVLQTHSVFVNVSKGQVAKKEDLISAFGTDDQTEICKQILTKGEVQVSDKERHTQLEQMFRDIATIVADKCVNPETKRPYTVILIERAMKDIHYSVKPNKSTKQQALEVIKQLKEKMKIERAHMRLRFLLPVNEGKKLKEKLKPLMKVVESEDYSQQLEIVCLIDPGCFREIDELIKKETKGKGSLEVLSLKDVEEGDEKFE
uniprot
proteins
function
FUNCTION: Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
28752
uniprot
proteins
protein_family
SDO1/SBDS family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
250
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Primarily detected in the cytoplasm, and at low levels in nucleus. Detected in the nucleolus during G1 and G2 phase of the cell cycle, and diffusely distributed in the nucleus during S phase. Detected at the mitotic spindle. Colocalizes with the microtubule organizing center during interphase (By similarity). {ECO:0000250}.
uniprot
proteins