Mei4
entrez
75033
canonical
uniprot
Q8BRM6
canonical
ensembl
ENSMUSG00000043289
resolver
ensp
ENSMUSP00000061341
resolver
ensp
ENSMUSP00000139589
resolver
ensp
ENSMUSP00000140647
resolver
enst
ENSMUST00000189391
resolver
genesymbol
Mei4
resolver
uniprot
A0A087WP18
resolver
uniprot
Q4V9Z7
resolver
uniprot
Q8C4E8
resolver
uniprot_entry
A0A087WP18_MOUSE
resolver
uniprot_entry
MEI4_MOUSE
resolver
uniprot_sec
Q4V9Z7
resolver
uniprot_sec
Q8C4E8
resolver
amino_acid_sequence
MDIQPWYLKTSKLALALAIIHSKPADRSSREYTEYLASLVTQKESTWKSKLEALEAEVLQLRQKLLLSRISSGLFKNGPDVLPTLSDQEPTSSENTLTLMDDSGCVLSNEQRNEPAELSQHFVESTDPPLLPLPLEKRPRTTLENPLSSHMQFFQHLLELKKWTESSSLKVYLTHFEKDSSTVSDSVSQLLDALITFYRNPKLPFSSFWTEAVGTLARLASDFNLSNHIFKRCSKKLEEFEKTLLQAILENNSINRFQVQRYVSQSLVTLGSCSLLRKSIISLLLSEVNSFVDDLGAIDQDQGIYDVTRYENIFSLFWILEQVLQQAPQGDRTAHMDHSIPEMQTFLQKHDEVIFRLSDAFPLFAFYLWRLGVLLNSAEMETVKNESLP
uniprot
proteins
function
FUNCTION: Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination (PubMed:20551173, PubMed:25795304, PubMed:27723721). Probably acts by forming a complex with IHO1 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis (PubMed:27723721). {ECO:0000269|PubMed:20551173, ECO:0000269|PubMed:25795304, ECO:0000269|PubMed:27723721}.
uniprot
proteins
mass_dalton
44471
uniprot
proteins
protein_family
MEI4L family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20551173
uniprot
proteins
pubmed
25795304
uniprot
proteins
pubmed
27723721
uniprot
proteins
pubmed
30569039
uniprot
proteins
sequence_length
389
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:20551173, ECO:0000269|PubMed:25795304, ECO:0000269|PubMed:30569039}. Note=Specifically localizes to unsynapsed chromosomal regions during meiosis (PubMed:25795304, PubMed:27723721). Located in discrete foci on the axes of meiotic chromosomes. The number of foci is highest at leptonema, decreases at zygonema and is strongly reduced in pachynema and subsequent stages (PubMed:20551173). {ECO:0000269|PubMed:20551173, ECO:0000269|PubMed:25795304, ECO:0000269|PubMed:27723721}.
uniprot
proteins