PLEKHG6
entrez
55200
canonical
uniprot
Q3KR16
canonical
ensembl
ENSG00000008323
resolver
ensp
ENSP00000011684
resolver
ensp
ENSP00000380185
resolver
ensp
ENSP00000393194
resolver
ensp
ENSP00000442836
resolver
ensp
ENSP00000506982
resolver
ensp
ENSP00000568503
resolver
ensp
ENSP00000598888
resolver
ensp
ENSP00000635636
resolver
enst
ENST00000536531
resolver
genesymbol
PLEKHG6
resolver
hgnc
HGNC:25562
resolver
uniprot
F5H731
resolver
uniprot
Q3SWR1
resolver
uniprot
Q8N1P1
resolver
uniprot
Q8WYY1
resolver
uniprot
Q9H8F4
resolver
uniprot
Q9NVK9
resolver
uniprot_entry
F5H731_HUMAN
resolver
uniprot_entry
PKHG6_HUMAN
resolver
uniprot_sec
Q3SWR1
resolver
uniprot_sec
Q8N1P1
resolver
uniprot_sec
Q8WYY1
resolver
uniprot_sec
Q9H8F4
resolver
uniprot_sec
Q9NVK9
resolver
amino_acid_sequence
MKAFGPPHEGPLQGLVASRIETYGGRHRASAQSTAGRLYPRGYPVLDPSRRRLQQYVPFARGSGQARGLSPMRLRDPEPEKRHGGHVGAGLLHSPKLKELTKAHELEVRLHTFSMFGMPRLPPEDRRHWEIGEGGDSGLTIEKSWRELVPGHKEMSQELCHQQEALWELLTTELIYVRKLKIMTDLLAAGLLNLQRVGLLMEVSAETLFGNVPSLIRTHRSFWDEVLGPTLEETRASGQPLDPIGLQSGFLTFGQRFHPYVQYCLRVKQTMAYAREQQETNPLFHAFVQWCEKHKRSGRQMLCDLLIKPHQRITKYPLLLHAVLKRSPEARAQEALNAMIEAVESFLRHINGQVRQGEEQESLAAAAQRIGPYEVLEPPSDEVEKNLRPFSTLDLTSPMLGVASEHTRQLLLEGPVRVKEGREGKLDVYLFLFSDVLLVTKPQRKADKAKVIRPPLMLEKLVCQPLRDPNSFLLIHLTEFQCVSSALLVHCPSPTDRAQWLEKTQQAQAALQKLKAEEYVQQKRELLTLYRDQDRESPSTRPSTPSLEGSQSSAEGRTPEFSTIIPHLVVTEDTDEDAPLVPDDTSDSGYGTLIPGTPTGSRSPLSRLRQRALRRDPRLTFSTLELRDIPLRPHPPDPQAPQRRSAPELPEGILKGGSLPQEDPPTWSEEEDGASERGNVVVETLHRARLRGQLPSSPTHADSAGESPWESSGEEEEEGPLFLKAGHTSLRPMRAEDMLREIREELASQRIEGAEEPRDSRPRKLTRAQLQRMRGPHIIQLDTPLSASEV
uniprot
proteins
function
FUNCTION: Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis. {ECO:0000269|PubMed:16721066, ECO:0000269|PubMed:17881735}.
uniprot
proteins
mass_dalton
88960
uniprot
proteins
mutagenesis
MUTAGEN 351; /note="N->A: Loss of exchange activity."; /evidence="ECO:0000269|PubMed:17881735
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
16721066
uniprot
proteins
pubmed
17881735
uniprot
proteins
pubmed
19129481
uniprot
proteins
sequence_length
790
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, microvillus {ECO:0000269|PubMed:17881735}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:16721066}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:16721066}. Cleavage furrow {ECO:0000269|PubMed:16721066}. Note=During mitosis, localizes to the spindle pole, central spindle and cleavage furrow (PubMed:16721066). In epithelial cells, recruited to the apical membrane by EZR where it participates in macropinocytosis (PubMed:17881735). {ECO:0000269|PubMed:16721066, ECO:0000269|PubMed:17881735}.
uniprot
proteins