Katnal1
entrez
231912
canonical
uniprot
Q8K0T4
canonical
ensembl
ENSMUSG00000041298
resolver
ensp
ENSMUSP00000043210
resolver
ensp
ENSMUSP00000313397
resolver
enst
ENSMUST00000047257
resolver
genesymbol
Katnal1
resolver
uniprot_entry
KATL1_MOUSE
resolver
amino_acid_sequence
MNLAEICENAKKGREYALLGNYDSSMVYYQGVIQQIQRHCQSLRDPATKAKWQQVRQELLEEYEQVKSIVSTLESFKMDKPPDFPVSCRDEPFRDPAVWPPPVPAEHRAPPQIRRPNREVRPLRKDVGAGARGLVGRAHQISKSDKPASRDKDYRARGRDDKARKNVQDGASDSEIPKFDGAGYDKDLVEALERDIVSRNPSIHWDDIADLEEAKKLLREAVVLPMWMPDFFKGIRRPWKGVLMVGPPGTGKTMLAKAVATECGTTFFNVSSSTLTSKYRGESEKLVRLLFEMARFYAPTTIFIDEIDSICSRRGTSDEHEASRRVKSELLIQMDGVGGALENDDPSKMVMVLAATNFPWDIDEALRRRLEKRIYIPLPTAKGRAELLKISLREVELDPDVHLEDIADKTEGYSGADITNICRDASLMAMRRRINGLSPEEIRALSKEELQMPVTRGDLELALKKIAKSVSAADLEKYEKWMVEFGSA
uniprot
proteins
ec_number
5.6.1.1
uniprot
proteins
function
FUNCTION: Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (PubMed:22654668). Has microtubule-severing activity in vitro (By similarity). {ECO:0000250|UniProtKB:Q9BW62, ECO:0000269|PubMed:22654668}.
uniprot
proteins
mass_dalton
55165
uniprot
proteins
mutagenesis
MUTAGEN 286; /note="L->V: Males are infertile and show a significant reduction in the number of spermatids in testis, due to premature exfoliation of spermatids from the seminiferous epithelium. Sertoli cells contain reduced numbers of stable microtubules. The protein localizes exclusively to the basal compartment of Sertoli cells."; /evidence="ECO:0000269|PubMed:22654668
uniprot
proteins
protein_family
A-like 1 sub-subfamily
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
protein_family
Katanin p60 subunit A1 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22654668
uniprot
proteins
sequence_length
488
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03024, ECO:0000269|PubMed:22654668}. Cytoplasm {ECO:0000250|UniProtKB:Q9BW62}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q9BW62}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9BW62}. Note=Colocalizes with microtubules throughout the basal and adluminal compartments of Sertoli cells (PubMed:22654668). Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis (By similarity). {ECO:0000250|UniProtKB:Q9BW62, ECO:0000269|PubMed:22654668}.
uniprot
proteins