IL10RB
entrez
3588
canonical
uniprot
Q08334
canonical
ensembl
ENSG00000243646
resolver
ensp
ENSP00000290200
resolver
ensp
ENSP00000489716
resolver
ensp
ENSP00000489965
resolver
ensp
ENSP00000788387
resolver
enst
ENST00000290200
resolver
enst
ENST00000609556
resolver
enst
ENST00000637650
resolver
genesymbol
IL10RB
resolver
genesymbol_syn
CRFB4
resolver
genesymbol_syn
D21S58
resolver
genesymbol_syn
D21S66
resolver
hgnc
HGNC:5965
resolver
uniprot
A0A1B0GTI5
resolver
uniprot
A0A1B0GU52
resolver
uniprot
Q9BUU4
resolver
uniprot_entry
A0A1B0GTI5_HUMAN
resolver
uniprot_entry
A0A1B0GU52_HUMAN
resolver
uniprot_entry
I10R2_HUMAN
resolver
uniprot_sec
Q9BUU4
resolver
amino_acid_sequence
MAWSLGSWLGGCLLVSALGMVPPPENVRMNSVNFKNILQWESPAFAKGNLTFTAQYLSYRIFQDKCMNTTLTECDFSSLSKYGDHTLRVRAEFADEHSDWVNITFCPVDDTIIGPPGMQVEVLADSLHMRFLAPKIENEYETWTMKNVYNSWTYNVQYWKNGTDEKFQITPQYDFEVLRNLEPWTTYCVQVRGFLPDRNKAGEWSEPVCEQTTHDETVPSWMVAVILMASVFMVCLALLGCFALLWCVYKKTKYAFSPRNSLPQHLKEFLGHPHHNTLLFFSFPLSDENDVFDKLSVIAEDSESGKQNPGDSCSLGTPPGQGPQS
uniprot
proteins
disease_involvement
DISEASE: Inflammatory bowel disease 25, autosomal recessive (IBD25) [MIM:612567]: A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. {ECO:0000269|PubMed:19890111}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IFNL1. The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. {ECO:0000269|PubMed:12469119, ECO:0000269|PubMed:15123776}.
uniprot
proteins
mass_dalton
36995
uniprot
proteins
protein_family
Type II cytokine receptor family
uniprot
proteins
pubmed
10875937
uniprot
proteins
pubmed
12469119
uniprot
proteins
pubmed
15123776
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16757563
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19890111
uniprot
proteins
pubmed
20462497
uniprot
proteins
pubmed
7563119
uniprot
proteins
pubmed
8314576
uniprot
proteins
pubmed
9312047
uniprot
proteins
sequence_length
325
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 221..242; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins