Poc1b
entrez
382406
canonical
uniprot
Q8BHD1
canonical
ensembl
ENSMUSG00000019952
resolver
ensp
ENSMUSP00000020113
resolver
enst
ENSMUST00000020113
resolver
genesymbol
Poc1b
resolver
genesymbol_syn
Wdr51b
resolver
uniprot_entry
POC1B_MOUSE
resolver
amino_acid_sequence
MASGLEDPILERSFKGHKAAITSADFSPNCKQIATASWDTFLMLWSLKPHARAYRYVGHKDVVTSLQFSPQGNLLASASRDRTVRLWVLDRKGKSSEFKAHTAPVRSVDFSADGQLLVTASEDKSIKVWSMFRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPNGTCIASAGSDHAVKIWDIRMNKLLQHYQVHSCGVNCLSFHPLGNSLVTASSDGTVKMLDLIEGRLIYTLQGHTGPVFTVSFSKDGELLTSGGADAQVLIWRTNFIHLHCKDPKRNLKRLHFEASPHLLDIYPRSPHSHEDRKETIEINPKREVMDLQSSSPPVVDVLSFDSTTMTDSTYRAVPGKGEDICRYFLNPLLMPECSSTTVKKRPEDVSDVPSESLRSVPLAVADALEHIMEQLNILTQTVSILEQRLSLTEDKLRDCLENQQKLFSAVQQKS
uniprot
proteins
function
FUNCTION: Plays an important role in centriole assembly and/or stability and ciliogenesis. Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Acts in concert with POC1A to ensure centriole integrity and proper mitotic spindle formation. Required for primary cilia formation, ciliary length and also cell proliferation. Required for retinal integrity. Acts as a positive regulator of centriole elongation. {ECO:0000250|UniProtKB:Q8TC44}.
uniprot
proteins
mass_dalton
53504
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in mitotic cells that may be mediated by CDK1. {ECO:0000250}.
uniprot
proteins
protein_family
WD repeat POC1 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
25044745
uniprot
proteins
sequence_length
476
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:25044745}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:25044745}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q8TC44}. Note=Component of both mother and daughter centrioles. Localizes to the basal body and centriole adjacent to the connecting cilium of photoreceptors and in synapses of the outer plexiform layer. Localizes to the inner scaffold in the central region of centrioles. {ECO:0000250|UniProtKB:Q8TC44, ECO:0000269|PubMed:25044745}.
uniprot
proteins