Nr6a1
entrez
14536
canonical
uniprot
Q64249
canonical
ensembl
ENSMUSG00000063972
resolver
ensp
ENSMUSP00000075624
resolver
ensp
ENSMUSP00000126009
resolver
ensp
ENSMUSP00000196894
resolver
genesymbol
Nr6a1
resolver
genesymbol_syn
Gcnf
resolver
uniprot
A2AQL8
resolver
uniprot
A2AQM1
resolver
uniprot
Q687Z3
resolver
uniprot_entry
NR6A1_MOUSE
resolver
uniprot_sec
A2AQL8
resolver
uniprot_sec
A2AQM1
resolver
uniprot_sec
Q687Z3
resolver
amino_acid_sequence
MERDERPPSGGGGGGGSAGFLEPPAALPPPPRNGFCQDELAELDPGTNGETDSLTLGQGHIPVSVPDDRAEQRTCLICGDRATGLHYGIISCEGCKGFFKRSICNKRVYRCSRDKNCVMSRKQRNRCQYCRLLKCLQMGMNRKAIREDGMPGGRNKSIGPVQISEEEIERIMSGQEFEEEANHWSNHGDSDHSSPGNRASESNQPSPGSTLSSSRSVELNGFMAFRDQYMGMSVPPHYQYIPHLFSYSGHSPLLPPQARSLDPQSYSLIHQLMSAEDLEPLGTPMLIEDGYAVTQAELFALLCRLADELLFRQIAWIKKLPFFCELSIKDYTCLLSSTWQELILLSSLTVYSKQIFGELADVTAKYSPSDEELHRFSDEGMEVIERLIYLYHKFHQLKVSNEEYACMKAINFLNQDIRGLTSASQLEQLNKRYWYICQDFTEYKYTHQPNRFPDLMMCLPEIRYIAGKMVNVPLEQLPLLFKVVLHSCKTSTVKE
uniprot
proteins
function
FUNCTION: Orphan nuclear receptor that binds to a response element containing the sequence 5'-TCAAGGTCA-3' (PubMed:11702949, PubMed:27984042, PubMed:7854358). Acts as a regulator of embryonic stem cell pluripotency by mediating repression of POU5F1/OCT4: binds to the DR0 element within the POU5F1/OCT4 promoter and inhibits POU5F1/OCT4 expression during embryonic stem cell differentiation (PubMed:11702949, PubMed:27984042). Required to restrict POU5F1/OCT4 expression to the germ cell lineage (PubMed:11702949). Involved in the regulation of gene expression in germ cell development during gametogenesis (PubMed:7854358). {ECO:0000269|PubMed:11702949, ECO:0000269|PubMed:27984042, ECO:0000269|PubMed:7854358}.
uniprot
proteins
mass_dalton
55976
uniprot
proteins
mutagenesis
MUTAGEN 149..151; /note="GMP->RMR: Increased DNA-binding to target genes."; /evidence="ECO:0000269|PubMed:27984042"; MUTAGEN 246..247; /note="SY->GG: Abolishes interaction with RXRIP110."; /evidence="ECO:0000269|PubMed:12080054"; MUTAGEN 254..255; /note="LP->AA: Does not abolish interaction with RXRIP110."; /evidence="ECO:0000269|PubMed:12080054"; MUTAGEN 265..266; /note="SY->AA: Does not abolish interaction with RXRIP110."; /evidence="ECO:0000269|PubMed:12080054
uniprot
proteins
protein_family
NR6 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
11178239
uniprot
proteins
pubmed
11702949
uniprot
proteins
pubmed
12080054
uniprot
proteins
pubmed
12606326
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
27984042
uniprot
proteins
pubmed
40610405
uniprot
proteins
pubmed
7760852
uniprot
proteins
pubmed
7835709
uniprot
proteins
pubmed
7854358
uniprot
proteins
pubmed
9025060
uniprot
proteins
sequence_length
495
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins