LRCH4
entrez
4034
canonical
uniprot
O75427
canonical
ensembl
ENSG00000077454
resolver
ensp
ENSP00000309689
resolver
ensp
ENSP00000419674
resolver
ensp
ENSP00000547700
resolver
ensp
ENSP00000547701
resolver
ensp
ENSP00000547702
resolver
ensp
ENSP00000547708
resolver
ensp
ENSP00000662678
resolver
ensp
ENSP00000662683
resolver
ensp
ENSP00000710807
resolver
ensp
ENSP00000710809
resolver
enst
ENST00000310300
resolver
enst
ENST00000485554
resolver
genesymbol
LRCH4
resolver
genesymbol_syn
LRN
resolver
genesymbol_syn
LRRN1
resolver
genesymbol_syn
LRRN4
resolver
hgnc
HGNC:6691
resolver
uniprot
A4D2D5
resolver
uniprot
B4DYF8
resolver
uniprot
H7C5D9
resolver
uniprot
Q8WV85
resolver
uniprot
Q96ID0
resolver
uniprot_entry
B4DYF8_HUMAN
resolver
uniprot_entry
H7C5D9_HUMAN
resolver
uniprot_entry
LRCH4_HUMAN
resolver
uniprot_sec
A4D2D5
resolver
uniprot_sec
Q8WV85
resolver
uniprot_sec
Q96ID0
resolver
amino_acid_sequence
MAAAVAAPLAAGGEEAAATTSVPGSPGLPGRRSAERALEEAVATGTLNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQLPLRVLIVSNNKLGALPPDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLPLVRLDFSCNRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQVCLKGKLHIFKYLSTEAGQRGSALGDLAPSRPPSFSPCPAEDLFPGHRYDGGLDSGFHSVDSGSKRWSGNESTDEFSELSFRISELAREPRGPRERKEDGSADGDPVQIDFIDSHVPGEDEERGTVEEQRPPELSPGAGDRERAPSSRREEPAGEERRRPDTLQLWQERERRQQQQSGAWGAPRKDSLLKPGLRAVVGGAAAVSTQAMHNGSPKSSASQAGAAAGQGAPAPAPASQEPLPIAGPATAPAPRPLGSIQRPNSFLFRSSSQSGSGPSSPDSVLRPRRYPQVPDEKDLMTQLRQVLESRLQRPLPEDLAEALASGVILCQLANQLRPRSVPFIHVPSPAVPKLSALKARKNVESFLEACRKMGVPEADLCSPSDLLQGTARGLRTALEAVKRVGGKALPPLWPPSGLGGFVVFYVVLMLLLYVTYTRLLGS
uniprot
proteins
function
FUNCTION: Accessory protein that regulates signaling by multiple TLRs, acting as a broad-spanning regulator of the innate immune response. In macrophages, binds LPS and promotes proper docking of LPS in lipid raft membrane. May be required for lipid raft maintenance. {ECO:0000250|UniProtKB:Q921G6}.
uniprot
proteins
mass_dalton
73450
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9799793
uniprot
proteins
sequence_length
683
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q921G6}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 653..673; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins