A7E3N2
uniprot
A7E3N2
canonical
amino_acid_sequence
MSLAEAIRLWNEGVQAADKKDWKGALEAFSEVQDPHSRICFNIGCMYTILDNLQEAEQAFTKSINRDKHLAVAYFQRGMLYYSMEKYRPASVGRKAALLFLGSYNLVARIIVGYPLSPGKVLYNIALMHAKKEEWKKAEEQLALATNMKSEPRHSKIDKAMESIWKRCPTSHLPLDPPQVTMALWFEEGGVGKRSVVASVVHQDNFSGFAPLQPQSAEPPPRPKTPEIFRALEGEAHRVLFGFVPETPEELQVMPGNIVFVLKKGSDNWATVMFNGQKGLVPCNYLEPVELRIHPQSQPQEDTSLESDIPPPPNSSPPERLQLSPGWCQQLGPLRCPPFLLHQEVKRSVPMPYMLKVHYKYTVVMETQLGLPYSQLRNMVSKKLELLPEHTKLSYQRRDSPELLLLSEESMKDAWAQVKNYCLTLWCEHTVGDQGFVDEPKEKENSDADNRTTEPQPKEGTQVVAIFSYDATQPEDLEFVEGDVILVLSHVNEEWLEGECKGKIGIFPKAFVEGCAAKNLEGTPREV
uniprot
proteins
function
FUNCTION: Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction. Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane (By similarity). This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox (By similarity). {ECO:0000250|UniProtKB:P14598, ECO:0000250|UniProtKB:P19878}.
uniprot
proteins
mass_dalton
59573
uniprot
proteins
protein_family
NCF2/NOXA1 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
17612411
uniprot
proteins
sequence_length
527
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
uniprot
proteins