Hcrtr2
entrez
387285
canonical
uniprot
P58308
canonical
ensembl
ENSMUSG00000032360
resolver
ensp
ENSMUSP00000058230
resolver
ensp
ENSMUSP00000139377
resolver
genesymbol
Hcrtr2
resolver
genesymbol_syn
Mox2r
resolver
uniprot
Q5SGC8
resolver
uniprot
Q6VLX3
resolver
uniprot
Q8BG12
resolver
uniprot_entry
OX2R_MOUSE
resolver
uniprot_sec
Q5SGC8
resolver
uniprot_sec
Q6VLX3
resolver
uniprot_sec
Q8BG12
resolver
amino_acid_sequence
MSSTKLEDSLSRRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVVIWIVSCIIMIPQAIVMECSSMLPGLANKTTLFTVCDEHWGGEVYPKMYHICFFLVTYMAPLCLMILAYLQIFRKLWCRQIPGTSSVVQRKWKQQQPVSQPRGSGQQSKARISAVAAEIKQIRARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCLGVHHRQGDRLARGRTSTESRKSLTTQISNFDNVSKLSEHVVLTSISTLPAANGAGPLQNWYLQQGVPSSLLSTWLEV
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that binds neuropeptides orexin-A and orexin-B, two neuropeptides derived from a common precursor, prepro-orexin (PubMed:15256537). Upon neuropeptide ligand binding, HCRTR2 can couple with both G(q)/11 and G(i)/o heterotrimeric G-proteins thereby initiating distinct downstream signaling cascades (By similarity). Involved in regulating the sleep-wake cycle (PubMed:12797957). Contributes to central regulation of glucose homeostasis (PubMed:34475397). {ECO:0000250|UniProtKB:O43614, ECO:0000269|PubMed:12797957, ECO:0000269|PubMed:15256537, ECO:0000269|PubMed:34475397}.
uniprot
proteins
mass_dalton
52461
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12797957
uniprot
proteins
pubmed
15256537
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
34475397
uniprot
proteins
sequence_length
460
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O43614}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O43614}.
uniprot
proteins
transmembrane_region
TRANSMEM 55..75; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:O43614"; TRANSMEM 89..110; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:O43614"; TRANSMEM 128..150; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:O43614"; TRANSMEM 171..191; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:O43614"; TRANSMEM 223..243; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:O43614"; TRANSMEM 305..326; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:O43614"; TRANSMEM 343..366; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:O43614
uniprot
proteins