FGD2
entrez
221472
canonical
uniprot
Q7Z6J4
canonical
ensembl
ENSG00000146192
resolver
ensp
ENSP00000274963
resolver
ensp
ENSP00000520784
resolver
enst
ENST00000718347
resolver
genesymbol
FGD2
resolver
genesymbol_syn
ZFYVE4
resolver
hgnc
HGNC:3664
resolver
uniprot
A0ABB0MVF6
resolver
uniprot
Q5T8I1
resolver
uniprot
Q6P6A8
resolver
uniprot
Q6ZNL5
resolver
uniprot
Q8IZ32
resolver
uniprot
Q8N868
resolver
uniprot
Q9H7M2
resolver
uniprot_entry
A0ABB0MVF6_HUMAN
resolver
uniprot_entry
FGD2_HUMAN
resolver
uniprot_sec
Q5T8I1
resolver
uniprot_sec
Q6P6A8
resolver
uniprot_sec
Q6ZNL5
resolver
uniprot_sec
Q8IZ32
resolver
uniprot_sec
Q8N868
resolver
uniprot_sec
Q9H7M2
resolver
amino_acid_sequence
MKGASEEKLASVSNLVTVFENSRTPEAAPRGQRLEDVHHRPECRPPESPGPREKTNVGEAVGSEPRTVSRRYLNSLKNKLSSEAWRKSCQPVTLSGSGTQEPEKKIVQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQFHSQFFLPELQRRLDDWTANPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEVLTRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFSAAQHSNAAITEMERLQDLWEVYQRLGLEDDIVDPSNTLLREGPVLKISFRRNDPMERYLFLFNNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVRELMDAEFPHSFLVSGKQRTLELQARSQEEMISWMQAFQAAIDQIEKRNETFKAAAQGPEGDIQEQELQSEELGLRAPQWVRDKMVTMCMRCQEPFNALTRRRHHCRACGYVVCARCSDYRAELKYDDNRPNRVCLHCYAFLTGNVLPEAKEDKRRGILEKGSSATPDQSLMCSFLQLIGDKWGKSGPRGWCVIPRDDPLVLYVYAAPQDMRAHTSIPLLGYQVTVGPQGDPRVFQLQQSGQLYTFKAETEELKGRWVKAMERAASGWSPSWPNDGDLSD
uniprot
proteins
function
FUNCTION: Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Activates JNK1 via CDC42 but not RAC1. Binds to phosphatidylinositol 4,5-bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
74892
uniprot
proteins
pubmed
11214971
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
655
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000305}. Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Early endosome {ECO:0000250}. Early endosome membrane {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Note=Recruitment to the endosome and ruffle membrane requires the presence of phosphoinositides. {ECO:0000250}.
uniprot
proteins