Srd5a2
entrez
64677
canonical
uniprot
P31214
canonical
ensembl
ENSRNOG00000027042
resolver
ensembl
ENSRNOG00055020662
resolver
ensembl
ENSRNOG00060012768
resolver
ensembl
ENSRNOG00065020764
resolver
ensp
ENSRNOP00000108368
resolver
ensp
ENSRNOP00055028595
resolver
ensp
ENSRNOP00060017178
resolver
ensp
ENSRNOP00065028325
resolver
enst
ENSRNOT00000170207
resolver
enst
ENSRNOT00055035273
resolver
enst
ENSRNOT00060021711
resolver
enst
ENSRNOT00065035212
resolver
genesymbol
Srd5a2
resolver
uniprot_entry
S5A2_RAT
resolver
amino_acid_sequence
MQIVCHQVPVLAGSATLATMGTLILCLGKPASYGKHTESVSSGVPFLPARIAWFLQELPSFVVSVGMLAWQPRSLFGPPGNVLLALFSAHYFHRTFIYSLLTRGRPFPAVLFLRATAFCIGNGLLQAYYLVYCAEYPEEWYTDVRFSFGVFLFILGMGINIHSDYTLRQLRKPGEVIYRIPRGGLFTYVSGANFLGEIIEWIGYALATWSVPAFAFAFFTLCFLGMQAFYHHRFYLKMFKDYPKSRKALIPFIF
uniprot
proteins
ec_number
1.3.1.22
uniprot
proteins
function
FUNCTION: Catalyzes the irreversible stereospecific reduction of the delta 4,5 bond (double bond between carbons 4 and 5) of various 3-oxo steroids (3-keto steroids) producing their 5alpha dihydro-3-oxo forms (PubMed:1527072). Converts testosterone into 5-alpha-dihydrotestosterone (DHT), the most active androgen in the prostate, as it is the preferred ligand for androgen receptor (AR) transactivation, making this reaction a key step in male sexual differentiation during development (PubMed:1527072). Besides testosterone, it can also act on other steroids, including progesterone, producing metabolites with diverse roles (PubMed:1527072). Hence, it plays a central role in sexual differentiation and androgen physiology (By similarity). {ECO:0000250|UniProtKB:P31213, ECO:0000269|PubMed:1527072}.
uniprot
proteins
mass_dalton
28772
uniprot
proteins
protein_family
Steroid 5-alpha reductase family
uniprot
proteins
pubmed
1527072
uniprot
proteins
sequence_length
254
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 72..92; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 146..166; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 206..226; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins