Arx
entrez
11878
canonical
uniprot
O35085
canonical
ensembl
ENSMUSG00000035277
resolver
ensp
ENSMUSP00000049039
resolver
ensp
ENSMUSP00000109580
resolver
enst
ENSMUST00000046565
resolver
enst
ENSMUST00000113947
resolver
genesymbol
Arx
resolver
uniprot
A2A4G9
resolver
uniprot
Q9QYT4
resolver
uniprot_entry
ARX_MOUSE
resolver
uniprot_sec
A2A4G9
resolver
uniprot_sec
Q9QYT4
resolver
amino_acid_sequence
MSNQYQEEGCSERPECKSKSPTLLSSYCIDSILGRRSPCKMRLLGAAQSLPAPLASRADQEKAMQGSPKSSSAPFEAELHLPPKLRRLYGPGGGRLLQGAAAAAAAAAAAAAAATATGTAGPRGEVPPPPPPAARPGERQDSAGAVAAAAAAAAWDTLKISQAPQVSISRSKSYRENGAPFVPPPPALDELSGPGGVAHPEERLSAASGPGSAPAAGGGTGAEDDEEELLEDEEDEEEEEELLEDDDEELLEDDARALLKEPRRCSVATTGTVAAAAAAAAAAVATEGGELSPKEELLLHPEDAEGKDGEDSVCLSAGSDSEEGLLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKAGAQTHPPGLPFPGPLSATHPLSPYLDASPFPPHHPALDSAWTAAAAAAAAAFPSLPPPPGSASLPPSGAPLGLSTFLGAAVFRHPAFISPAFGRLFSTMAPLTSASTAAALLRQPTPAVEGAVASGALADPATAAADRRASSIAALRLKAKEHAAQLTQLNILPGTSTGKEVC
uniprot
proteins
function
FUNCTION: DNA-binding transcription factor that plays a central role in the differentiation and development of type A pancreatic cells, which are located in the islets of Langerhans and secrete glucagon (PubMed:14561778, PubMed:15930104). Binds to specific sequence motif 5'-TAATTA-3' in regulatory elements of target genes (By similarity). Also plays a key role in intestinal enteroendocrine cell differentiation by promoting differentiation of intestinal enteroendocrine cell types L, -N, -D, -I and -G (PubMed:22387004, PubMed:22570716). Required for normal brain development: plays a role in neuronal proliferation, interneuronal migration and differentiation in the embryonic forebrain (PubMed:12379852, PubMed:31691806). May also be involved in axonal guidance in the floor plate (PubMed:9256348). Promotes expression of transcription of KDM5C (PubMed:31691806). Activates expression of KDM5C synergistically with histone lysine demethylase PHF8 and perhaps in competition with transcription regulator ZNF711; synergy may be related to enrichment of histone H3K4me3 in regulatory elements (By similarity). {ECO:0000250|UniProtKB:Q96QS3, ECO:0000269|PubMed:12379852, ECO:0000269|PubMed:14561778, ECO:0000269|PubMed:15930104, ECO:0000269|PubMed:22387004, ECO:0000269|PubMed:22570716, ECO:0000269|PubMed:31691806, ECO:0000269|PubMed:9256348}.
uniprot
proteins
mass_dalton
58490
uniprot
proteins
protein_family
Bicoid subfamily
uniprot
proteins
protein_family
Paired homeobox family
uniprot
proteins
pubmed
12379852
uniprot
proteins
pubmed
14561778
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15930104
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22387004
uniprot
proteins
pubmed
22570716
uniprot
proteins
pubmed
31691806
uniprot
proteins
pubmed
9256348
uniprot
proteins
sequence_length
564
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138}. Chromosome {ECO:0000250|UniProtKB:Q96QS3}.
uniprot
proteins