HLA-A
entrez
3105
canonical
uniprot
P04439
canonical
ensembl
ENSG00000206503
resolver
ensembl
ENSG00000224320
resolver
ensembl
ENSG00000229215
resolver
ensp
ENSP00000366005
resolver
ensp
ENSP00000404678
resolver
ensp
ENSP00000406366
resolver
ensp
ENSP00000447614
resolver
ensp
ENSP00000447635
resolver
enst
ENST00000431930
resolver
enst
ENST00000443552
resolver
enst
ENST00000549869
resolver
enst
ENST00000552193
resolver
genesymbol
HLA-A
resolver
genesymbol_syn
HLAA
resolver
hgnc
HGNC:4931
resolver
uniprot
A0A5S8K7B8
resolver
uniprot
B1PKY1
resolver
uniprot
B1PKZ3
resolver
uniprot
B2R7U3
resolver
uniprot
O02939
resolver
uniprot
O02954
resolver
uniprot
O02955
resolver
uniprot
O02963
resolver
uniprot
O19509
resolver
uniprot
O19546
resolver
uniprot
O19598
resolver
uniprot
O19605
resolver
uniprot
O19606
resolver
uniprot
O19619
resolver
uniprot
O19647
resolver
uniprot
O19673
resolver
uniprot
O19687
resolver
uniprot
O19695
resolver
uniprot
O19756
resolver
uniprot
O19794
resolver
uniprot
O19795
resolver
uniprot
O43906
resolver
uniprot
O43907
resolver
uniprot
O46874
resolver
uniprot
O62921
resolver
uniprot
O62924
resolver
uniprot
O77937
resolver
uniprot
O77938
resolver
uniprot
O77964
resolver
uniprot
O78073
resolver
uniprot
O78171
resolver
uniprot
O98009
resolver
uniprot
O98010
resolver
uniprot
O98011
resolver
uniprot
O98137
resolver
uniprot
P01891
resolver
uniprot
P01892
resolver
uniprot
P05534
resolver
uniprot
P06338
resolver
uniprot
P10313
resolver
uniprot
P10314
resolver
uniprot
P10315
resolver
uniprot
P10316
resolver
uniprot
P13746
resolver
uniprot
P16188
resolver
uniprot
P16189
resolver
uniprot
P16190
resolver
uniprot
P18462
resolver
uniprot
P30443
resolver
uniprot
P30444
resolver
uniprot
P30445
resolver
uniprot
P30446
resolver
uniprot
P30447
resolver
uniprot
P30448
resolver
uniprot
P30449
resolver
uniprot
P30450
resolver
uniprot
P30451
resolver
uniprot
P30452
resolver
uniprot
P30453
resolver
uniprot
P30454
resolver
uniprot
P30455
resolver
uniprot
P30456
resolver
uniprot
P30457
resolver
uniprot
P30458
resolver
uniprot
P30459
resolver
uniprot
P30512
resolver
uniprot
P30514
resolver
uniprot
P79505
resolver
uniprot
P79562
resolver
uniprot
P79563
resolver
uniprot
Q09160
resolver
uniprot
Q29680
resolver
uniprot
Q29747
resolver
uniprot
Q29835
resolver
uniprot
Q29837
resolver
uniprot
Q29838
resolver
uniprot
Q29899
resolver
uniprot
Q29908
resolver
uniprot
Q29909
resolver
uniprot
Q29910
resolver
uniprot
Q30208
resolver
uniprot
Q31623
resolver
uniprot
Q5S3G1
resolver
uniprot
Q5SUL5
resolver
uniprot
Q65A82
resolver
uniprot
Q8MHM1
resolver
uniprot
Q8MHN9
resolver
uniprot
Q95352
resolver
uniprot
Q95355
resolver
uniprot
Q95362
resolver
uniprot
Q95377
resolver
uniprot
Q95380
resolver
uniprot
Q95IZ5
resolver
uniprot
Q9BCN0
resolver
uniprot
Q9BD15
resolver
uniprot
Q9BD19
resolver
uniprot
Q9GJE6
resolver
uniprot
Q9GJE7
resolver
uniprot
Q9GJE8
resolver
uniprot
Q9MW42
resolver
uniprot
Q9MY89
resolver
uniprot
Q9MYA3
resolver
uniprot
Q9MYA5
resolver
uniprot
Q9MYC4
resolver
uniprot
Q9MYE6
resolver
uniprot
Q9MYE9
resolver
uniprot
Q9MYG4
resolver
uniprot
Q9MYG5
resolver
uniprot
Q9MYI5
resolver
uniprot
Q9TP25
resolver
uniprot
Q9TPQ3
resolver
uniprot
Q9TPR8
resolver
uniprot
Q9TPX8
resolver
uniprot
Q9TPX9
resolver
uniprot
Q9TPY0
resolver
uniprot
Q9TQ24
resolver
uniprot
Q9TQE8
resolver
uniprot
Q9TQE9
resolver
uniprot
Q9TQF1
resolver
uniprot
Q9TQF5
resolver
uniprot
Q9TQF8
resolver
uniprot
Q9TQF9
resolver
uniprot
Q9TQG0
resolver
uniprot
Q9TQG5
resolver
uniprot
Q9TQG7
resolver
uniprot
Q9TQH5
resolver
uniprot
Q9TQI3
resolver
uniprot
Q9TQK5
resolver
uniprot
Q9TQM6
resolver
uniprot
Q9TQN5
resolver
uniprot
Q9TQP5
resolver
uniprot
Q9TQP6
resolver
uniprot
Q9TQP7
resolver
uniprot
Q9UIN1
resolver
uniprot
Q9UIN2
resolver
uniprot
Q9UIP7
resolver
uniprot
Q9UQU3
resolver
uniprot
Q9UQU6
resolver
uniprot
Q9UQU7
resolver
uniprot_entry
A0A5S8K7B8_HUMAN
resolver
uniprot_entry
B1PKY1_HUMAN
resolver
uniprot_entry
B2R7U3_HUMAN
resolver
uniprot_entry
HLAA_HUMAN
resolver
uniprot_entry
Q5SUL5_HUMAN
resolver
uniprot_sec
B1PKZ3
resolver
uniprot_sec
O02939
resolver
uniprot_sec
O02954
resolver
uniprot_sec
O02955
resolver
uniprot_sec
O02963
resolver
uniprot_sec
O19509
resolver
uniprot_sec
O19546
resolver
uniprot_sec
O19598
resolver
uniprot_sec
O19605
resolver
uniprot_sec
O19606
resolver
uniprot_sec
O19619
resolver
uniprot_sec
O19647
resolver
uniprot_sec
O19673
resolver
uniprot_sec
O19687
resolver
uniprot_sec
O19695
resolver
uniprot_sec
O19756
resolver
uniprot_sec
O19794
resolver
uniprot_sec
O19795
resolver
uniprot_sec
O43906
resolver
uniprot_sec
O43907
resolver
uniprot_sec
O46874
resolver
uniprot_sec
O62921
resolver
uniprot_sec
O62924
resolver
uniprot_sec
O77937
resolver
uniprot_sec
O77938
resolver
uniprot_sec
O77964
resolver
uniprot_sec
O78073
resolver
uniprot_sec
O78171
resolver
uniprot_sec
O98009
resolver
uniprot_sec
O98010
resolver
uniprot_sec
O98011
resolver
uniprot_sec
O98137
resolver
uniprot_sec
P01891
resolver
uniprot_sec
P01892
resolver
uniprot_sec
P05534
resolver
uniprot_sec
P06338
resolver
uniprot_sec
P10313
resolver
uniprot_sec
P10314
resolver
uniprot_sec
P10315
resolver
uniprot_sec
P10316
resolver
uniprot_sec
P13746
resolver
uniprot_sec
P16188
resolver
uniprot_sec
P16189
resolver
uniprot_sec
P16190
resolver
uniprot_sec
P18462
resolver
uniprot_sec
P30443
resolver
uniprot_sec
P30444
resolver
uniprot_sec
P30445
resolver
uniprot_sec
P30446
resolver
uniprot_sec
P30447
resolver
uniprot_sec
P30448
resolver
uniprot_sec
P30449
resolver
uniprot_sec
P30450
resolver
uniprot_sec
P30451
resolver
uniprot_sec
P30452
resolver
uniprot_sec
P30453
resolver
uniprot_sec
P30454
resolver
uniprot_sec
P30455
resolver
uniprot_sec
P30456
resolver
uniprot_sec
P30457
resolver
uniprot_sec
P30458
resolver
uniprot_sec
P30459
resolver
uniprot_sec
P30512
resolver
uniprot_sec
P30514
resolver
uniprot_sec
P79505
resolver
uniprot_sec
P79562
resolver
uniprot_sec
P79563
resolver
uniprot_sec
Q09160
resolver
uniprot_sec
Q29680
resolver
uniprot_sec
Q29747
resolver
uniprot_sec
Q29835
resolver
uniprot_sec
Q29837
resolver
uniprot_sec
Q29838
resolver
uniprot_sec
Q29899
resolver
uniprot_sec
Q29908
resolver
uniprot_sec
Q29909
resolver
uniprot_sec
Q29910
resolver
uniprot_sec
Q30208
resolver
uniprot_sec
Q31623
resolver
uniprot_sec
Q5S3G1
resolver
uniprot_sec
Q65A82
resolver
uniprot_sec
Q8MHM1
resolver
uniprot_sec
Q8MHN9
resolver
uniprot_sec
Q95352
resolver
uniprot_sec
Q95355
resolver
uniprot_sec
Q95362
resolver
uniprot_sec
Q95377
resolver
uniprot_sec
Q95380
resolver
uniprot_sec
Q95IZ5
resolver
uniprot_sec
Q9BCN0
resolver
uniprot_sec
Q9BD15
resolver
uniprot_sec
Q9BD19
resolver
uniprot_sec
Q9GJE6
resolver
uniprot_sec
Q9GJE7
resolver
uniprot_sec
Q9GJE8
resolver
uniprot_sec
Q9MW42
resolver
uniprot_sec
Q9MY89
resolver
uniprot_sec
Q9MYA3
resolver
uniprot_sec
Q9MYA5
resolver
uniprot_sec
Q9MYC4
resolver
uniprot_sec
Q9MYE6
resolver
uniprot_sec
Q9MYE9
resolver
uniprot_sec
Q9MYG4
resolver
uniprot_sec
Q9MYG5
resolver
uniprot_sec
Q9MYI5
resolver
uniprot_sec
Q9TP25
resolver
uniprot_sec
Q9TPQ3
resolver
uniprot_sec
Q9TPR8
resolver
uniprot_sec
Q9TPX8
resolver
uniprot_sec
Q9TPX9
resolver
uniprot_sec
Q9TPY0
resolver
uniprot_sec
Q9TQ24
resolver
uniprot_sec
Q9TQE8
resolver
uniprot_sec
Q9TQE9
resolver
uniprot_sec
Q9TQF1
resolver
uniprot_sec
Q9TQF5
resolver
uniprot_sec
Q9TQF8
resolver
uniprot_sec
Q9TQF9
resolver
uniprot_sec
Q9TQG0
resolver
uniprot_sec
Q9TQG5
resolver
uniprot_sec
Q9TQG7
resolver
uniprot_sec
Q9TQH5
resolver
uniprot_sec
Q9TQI3
resolver
uniprot_sec
Q9TQK5
resolver
uniprot_sec
Q9TQM6
resolver
uniprot_sec
Q9TQN5
resolver
uniprot_sec
Q9TQP5
resolver
uniprot_sec
Q9TQP6
resolver
uniprot_sec
Q9TQP7
resolver
uniprot_sec
Q9UIN1
resolver
uniprot_sec
Q9UIN2
resolver
uniprot_sec
Q9UIP7
resolver
uniprot_sec
Q9UQU3
resolver
uniprot_sec
Q9UQU6
resolver
uniprot_sec
Q9UQU7
resolver
amino_acid_sequence
MAVMAPRTLLLLLSGALALTQTWAGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRAPWIEQEGPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEAGSHTIQIMYGCDVGSDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAAHEAEQLRAYLDGTCVEWLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWELSSQPTIPIVGIIAGLVLLGAVITGAVVAAVMWRRKSSDRKGGSYTQAASSDSAQGSDVSLTACKV
uniprot
proteins
disease_involvement
DISEASE: Note=Alleles A*02:01 and A*24:02 are associated with increased susceptibility to diabetes mellitus, insulin-dependent (IDDM) (PubMed:16731854, PubMed:18802479, PubMed:22245737, PubMed:22522618). In a glucose-dependent way, allele A*02:01 may aberrantly present the signal peptide of preproinsulin (ALWGPDPAAA) on the surface of pancreatic beta cells to autoreactive CD8-positive T cells, potentially driving T-cell mediated cytotoxicity in pancreatic islets (PubMed:18802479, PubMed:22245737). Allele A*24:02 may present the signal peptide of preproinsulin (LWMRLLPLL) and contribute to acute pancreatic beta-cell destruction and early onset of IDDM (PubMed:16731854, PubMed:22522618). {ECO:0000269|PubMed:16731854, ECO:0000269|PubMed:18802479, ECO:0000269|PubMed:22245737, ECO:0000269|PubMed:22522618}.; DISEASE: Note=Allele A*03:01 is associated with increased susceptibility to multiple sclerosis (MS), an autoimmune disease of the central nervous system (PubMed:10746785). May contribute to the initiation phase of the disease by presenting myelin PLP1 self-peptide (KLIETYFSK) to autoreactive CD8-positive T cells capable of initiating the first autoimmune attacks (PubMed:18953350). {ECO:0000269|PubMed:10746785, ECO:0000269|PubMed:18953350}.; DISEASE: Note=Allele A*26:01 is associated with increased susceptibility to Behcet disease (BD) in the Northeast Asian population. Especially in the HLA-B*51-negative BD populations, HLA-A*26 is significantly associated with the onset of BD. {ECO:0000269|PubMed:30872678}.; DISEASE: Note=Allele A*29:02 is associated with increased susceptibility to birdshot chorioretinopathy (BSCR). May aberrantly present retinal autoantigens and induce autoimmune uveitis. {ECO:0000269|PubMed:1728143}.
uniprot
proteins
function
FUNCTION: Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-A-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:10449296, PubMed:12138174, PubMed:12393434, PubMed:1402688, PubMed:15893615, PubMed:17189421, PubMed:19543285, PubMed:21498667, PubMed:24192765, PubMed:24395804, PubMed:2456340, PubMed:2784196, PubMed:28250417, PubMed:7504010, PubMed:7694806, PubMed:9862734). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:25880248, PubMed:7506728, PubMed:7679507). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:12796775, PubMed:18275829, PubMed:19542454, PubMed:28250417). Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via IFNG-induced immunoproteasome or via endopeptidase IDE/insulin-degrading enzyme (PubMed:17079320, PubMed:17189421, PubMed:20364150, PubMed:26929325, PubMed:27049119). Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9 (PubMed:7504010, PubMed:9862734). {ECO:0000269|PubMed:10449296, ECO:0000269|PubMed:12138174, ECO:0000269|PubMed:12393434, ECO:0000269|PubMed:12796775, ECO:0000269|PubMed:1402688, ECO:0000269|PubMed:15893615, ECO:0000269|PubMed:17079320, ECO:0000269|PubMed:17189421, ECO:0000269|PubMed:18275829, ECO:0000269|PubMed:19542454, ECO:0000269|PubMed:19543285, ECO:0000269|PubMed:20364150, ECO:0000269|PubMed:21498667, ECO:0000269|PubMed:24192765, ECO:0000269|PubMed:24395804, ECO:0000269|PubMed:2456340, ECO:0000269|PubMed:25880248, ECO:0000269|PubMed:26929325, ECO:0000269|PubMed:27049119, ECO:0000269|PubMed:2784196, ECO:0000269|PubMed:28250417, ECO:0000269|PubMed:7504010, ECO:0000269|PubMed:7506728, ECO:0000269|PubMed:7679507, ECO:0000269|PubMed:7694806, ECO:0000269|PubMed:9862734}.; FUNCTION: Allele A*01:01: Presents a restricted peptide repertoire including viral epitopes derived from IAV NP/nucleoprotein (CTELKLSDY), IAV PB1/polymerase basic protein 1 (VSDGGPNLY), HAdV-11 capsid L3/hexon protein (LTDLGQNLLY), SARS-CoV-2 3a/ORF3a (FTSDYYQLY) as well as tumor peptide antigens including MAGE1 (EADPTGHSY), MAGEA3 (EVDPIGHLY) and WT1 (TSEKRPFMCAY), all having in common a canonical motif with a negatively charged Asp or Glu residue at position 3 and a Tyr anchor residue at the C-terminus (PubMed:1402688, PubMed:17189421, PubMed:19177349, PubMed:20364150, PubMed:24395804, PubMed:25880248, PubMed:26758806, PubMed:30530481, PubMed:32887977, PubMed:7504010). A number of HLA-A*01:01-restricted peptides carry a post-translational modification with oxidation and N-terminal acetylation being the most frequent (PubMed:25880248). Fails to present highly immunogenic peptides from the EBV latent antigens (PubMed:18779413). {ECO:0000269|PubMed:1402688, ECO:0000269|PubMed:17189421, ECO:0000269|PubMed:18779413, ECO:0000269|PubMed:19177349, ECO:0000269|PubMed:20364150, ECO:0000269|PubMed:24395804, ECO:0000269|PubMed:25880248, ECO:0000269|PubMed:26758806, ECO:0000269|PubMed:30530481, ECO:0000269|PubMed:7504010}.; FUNCTION: Allele A*02:01: A major allele in human populations, presents immunodominant viral epitopes derived from IAV M/matrix protein 1 (GILGFVFTL), HIV-1 env (TLTSCNTSV), HIV-1 gag-pol (ILKEPVHGV), HTLV-1 Tax (LLFGYPVYV), HBV C/core antigen (FLPSDFFPS), HCMV UL83/pp65 (NLVPMVATV) as well as tumor peptide antigens including MAGEA4 (GVYDGREHTV), WT1 (RMFPNAPYL) and CTAG1A/NY-ESO-1 (SLLMWITQC), all having in common hydrophobic amino acids at position 2 and at the C-terminal anchors. {ECO:0000269|PubMed:11502003, ECO:0000269|PubMed:12138174, ECO:0000269|PubMed:12796775, ECO:0000269|PubMed:17079320, ECO:0000269|PubMed:18275829, ECO:0000269|PubMed:19542454, ECO:0000269|PubMed:20619457, ECO:0000269|PubMed:22245737, ECO:0000269|PubMed:26929325, ECO:0000269|PubMed:2784196, ECO:0000269|PubMed:28250417, ECO:0000269|PubMed:7694806, ECO:0000269|PubMed:7935798, ECO:0000269|PubMed:8630735, ECO:0000269|PubMed:8805302, ECO:0000269|PubMed:8906788, ECO:0000269|PubMed:9177355}.; FUNCTION: Allele A*03:01: Presents viral epitopes derived from IAV NP (ILRGSVAHK), HIV-1 nef (QVPLRPMTYK), HIV-1 gag-pol (AIFQSSMTK), SARS-CoV-2 N/nucleoprotein (KTFPPTEPK) as well as tumor peptide antigens including PMEL (LIYRRRLMK), NODAL (HAYIQSLLK), TRP-2 (RMYNMVPFF), all having in common hydrophobic amino acids at position 2 and Lys or Arg anchor residues at the C-terminus (PubMed:19543285, PubMed:21943705, PubMed:2456340, PubMed:32887977, PubMed:7504010, PubMed:7679507, PubMed:9862734). May also display spliced peptides resulting from the ligation of two separate proteasomal cleavage products that are not contiguous in the parental protein (PubMed:27049119). {ECO:0000269|PubMed:19543285, ECO:0000269|PubMed:21943705, ECO:0000269|PubMed:2456340, ECO:0000269|PubMed:27049119, ECO:0000269|PubMed:7504010, ECO:0000269|PubMed:7679507, ECO:0000269|PubMed:9862734}.; FUNCTION: Allele A*11:01: Presents several immunodominant epitopes derived from HIV-1 gag-pol and HHV-4 EBNA4, containing the peptide motif with Val, Ile, Thr, Leu, Tyr or Phe at position 2 and Lys anchor residue at the C-terminus. Important in the control of HIV-1, EBV and HBV infections (PubMed:10449296). Presents an immunodominant epitope derived from SARS-CoV-2 N/nucleoprotein (KTFPPTEPK) (PubMed:32887977). {ECO:0000269|PubMed:10449296, ECO:0000269|PubMed:32887977}.; FUNCTION: Allele A*23:01: Interacts with natural killer (NK) cell receptor KIR3DL1 and may contribute to functional maturation of NK cells and self-nonself discrimination during innate immune response. {ECO:0000269|PubMed:17182537}.; FUNCTION: Allele A*24:02: Presents viral epitopes derived from HIV-1 nef (RYPLTFGWCF), EBV lytic- and latent-cycle antigens BRLF1 (TYPVLEEMF), BMLF1 (DYNFVKQLF) and LMP2 (IYVLVMLVL), SARS-CoV nucleocapsid/N (QFKDNVILL), as well as tumor peptide antigens including PRAME (LYVDSLFFL), all sharing a common signature motif, namely an aromatic residue Tyr or Phe at position 2 and a nonhydrophobic anchor residue Phe, Leu or Iso at the C-terminus (PubMed:12393434, PubMed:20844028, PubMed:24192765, PubMed:9047241). Interacts with natural killer (NK) cell receptor KIR3DL1 and may contribute to functional maturation of NK cells and self-nonself discrimination during innate immune response (PubMed:17182537, PubMed:18502829). {ECO:0000269|PubMed:12393434, ECO:0000269|PubMed:17182537, ECO:0000269|PubMed:18502829, ECO:0000269|PubMed:20844028, ECO:0000269|PubMed:24192765, ECO:0000269|PubMed:9047241}.; FUNCTION: Allele A*26:01: Presents several epitopes derived from HIV-1 gag-pol (EVIPMFSAL, ETKLGKAGY) and env (LVSDGGPNLY), carrying as anchor residues preferentially Glu at position 1, Val or Thr at position 2 and Tyr at the C-terminus. {ECO:0000269|PubMed:15893615}.; FUNCTION: Allele A*29:02: Presents peptides having a common motif, namely a Glu residue at position 2 and Tyr or Leu anchor residues at the C-terminus. {ECO:0000269|PubMed:8622959}.; FUNCTION: Allele A*32:01: Interacts with natural killer (NK) cell receptor KIR3DL1 and may contribute to functional maturation of NK cells and self-nonself discrimination during innate immune response. {ECO:0000269|PubMed:17182537}.; FUNCTION: Allele A*68:01: Presents viral epitopes derived from IAV NP (KTGGPIYKR) and HIV-1 tat (ITKGLGISYGR), having a common signature motif namely, Val or Thr at position 2 and positively charged residues Arg or Lys at the C-terminal anchor. {ECO:0000269|PubMed:1448153, ECO:0000269|PubMed:1448154, ECO:0000269|PubMed:2784196}.; FUNCTION: Allele A*74:01: Presents immunodominant HIV-1 epitopes derived from gag-pol (GQMVHQAISPR, QIYPGIKVR) and rev (RQIHSISER), carrying an aliphatic residue at position 2 and Arg anchor residue at the C-terminus. May contribute to viral load control in chronic HIV-1 infection. {ECO:0000269|PubMed:21498667}.
uniprot
proteins
mass_dalton
40841
uniprot
proteins
mutagenesis
MUTAGEN 110; /note="N->Q: Impairs the recruitment of HLA-A*02 in the peptide-loading complex."; /evidence="ECO:0000269|PubMed:21263072"; MUTAGEN 156; /note="S->C: Impairs the maturation of a peptide-receptive HLA-A*02-B2M complex."; /evidence="ECO:0000269|PubMed:8805302"; MUTAGEN 158; /note="T->K: Impairs binding to TAP1-TAP2 transporter, resulting in impaired presentation of intracellular peptides."; /evidence="ECO:0000269|PubMed:8630735, ECO:0000269|PubMed:8805302
uniprot
proteins
post_translational_modification
PTM: (Microbial infection) Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system. {ECO:0000269|PubMed:12006494}.; PTM: N-linked glycosylation at Asn-110. {ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:21263072}.
uniprot
proteins
protein_family
MHC class I family
uniprot
proteins
pubmed
10449296
uniprot
proteins
pubmed
10746785
uniprot
proteins
pubmed
11390610
uniprot
proteins
pubmed
11502003
uniprot
proteins
pubmed
12006494
uniprot
proteins
pubmed
12138174
uniprot
proteins
pubmed
12393434
uniprot
proteins
pubmed
12796775
uniprot
proteins
pubmed
1317015
uniprot
proteins
pubmed
1402688
uniprot
proteins
pubmed
1431115
uniprot
proteins
pubmed
1448153
uniprot
proteins
pubmed
1448154
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15893615
uniprot
proteins
pubmed
16041067
uniprot
proteins
pubmed
16731854
uniprot
proteins
pubmed
17079320
uniprot
proteins
pubmed
17092262
uniprot
proteins
pubmed
17182537
uniprot
proteins
pubmed
17189421
uniprot
proteins
pubmed
1728143
uniprot
proteins
pubmed
1729171
uniprot
proteins
pubmed
1782566
uniprot
proteins
pubmed
18275829
uniprot
proteins
pubmed
18502829
uniprot
proteins
pubmed
18779413
uniprot
proteins
pubmed
18802479
uniprot
proteins
pubmed
18953350
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19177349
uniprot
proteins
pubmed
19542454
uniprot
proteins
pubmed
19543285
uniprot
proteins
pubmed
19735485
uniprot
proteins
pubmed
20356336
uniprot
proteins
pubmed
20364150
uniprot
proteins
pubmed
20619457
uniprot
proteins
pubmed
20844028
uniprot
proteins
pubmed
21263072
uniprot
proteins
pubmed
21428769
uniprot
proteins
pubmed
21498667
uniprot
proteins
pubmed
21543847
uniprot
proteins
pubmed
21943705
uniprot
proteins
pubmed
22245737
uniprot
proteins
pubmed
2251137
uniprot
proteins
pubmed
22522618
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2320591
uniprot
proteins
pubmed
24192765
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2431040
uniprot
proteins
pubmed
2437024
uniprot
proteins
pubmed
24395804
uniprot
proteins
pubmed
2456340
uniprot
proteins
pubmed
2460344
uniprot
proteins
pubmed
2461903
uniprot
proteins
pubmed
2478623
uniprot
proteins
pubmed
25880248
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26758806
uniprot
proteins
pubmed
26869717
uniprot
proteins
pubmed
26929325
uniprot
proteins
pubmed
27049119
uniprot
proteins
pubmed
2715640
uniprot
proteins
pubmed
2784196
uniprot
proteins
pubmed
28250417
uniprot
proteins
pubmed
28650991
uniprot
proteins
pubmed
2982951
uniprot
proteins
pubmed
30530481
uniprot
proteins
pubmed
30872678
uniprot
proteins
pubmed
32887977
uniprot
proteins
pubmed
3496393
uniprot
proteins
pubmed
35725941
uniprot
proteins
pubmed
37264229
uniprot
proteins
pubmed
3877632
uniprot
proteins
pubmed
41882355
uniprot
proteins
pubmed
6179086
uniprot
proteins
pubmed
6609814
uniprot
proteins
pubmed
7504010
uniprot
proteins
pubmed
7506728
uniprot
proteins
pubmed
7679507
uniprot
proteins
pubmed
7694806
uniprot
proteins
pubmed
7836067
uniprot
proteins
pubmed
7871528
uniprot
proteins
pubmed
7935798
uniprot
proteins
pubmed
8016845
uniprot
proteins
pubmed
8026990
uniprot
proteins
pubmed
8188325
uniprot
proteins
pubmed
8284791
uniprot
proteins
pubmed
8475492
uniprot
proteins
pubmed
8622959
uniprot
proteins
pubmed
8630735
uniprot
proteins
pubmed
8795145
uniprot
proteins
pubmed
8805302
uniprot
proteins
pubmed
8906788
uniprot
proteins
pubmed
9047241
uniprot
proteins
pubmed
9177355
uniprot
proteins
pubmed
92029
uniprot
proteins
pubmed
9349616
uniprot
proteins
pubmed
9349617
uniprot
proteins
pubmed
9862734
uniprot
proteins
sequence_length
365
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21263072, ECO:0000269|PubMed:25880248, ECO:0000269|PubMed:8805302}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000305|PubMed:8805302}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 309..332; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins