Dbnl
entrez
83527
canonical
uniprot
Q9JHL4
canonical
ensembl
ENSRNOG00000012378
resolver
ensp
ENSRNOP00000101080
resolver
genesymbol
Dbnl
resolver
genesymbol_syn
Sh3p7
resolver
uniprot
Q9JM66
resolver
uniprot
Q9JM67
resolver
uniprot
Q9JM74
resolver
uniprot_entry
DBNL_RAT
resolver
uniprot_sec
Q9JM66
resolver
uniprot_sec
Q9JM67
resolver
uniprot_sec
Q9JM74
resolver
amino_acid_sequence
MAVNLSRNGPALQEAYVRVVTEKSPTDWALFTYEGNSNDIRVAGTGEGGLEELVEELNSGKVMYAFCRVKDPNSGLPKFVLINWTGEGVNDVRKGACANHVSTMANFLKGAHVTINARAEEDVEPECIMEKVAKASGANYSFHKESSCFQDVGPQAPVGSVYQKTNAVSEIKRVGKDNFWAKAEKEEENRRLEEKRRAEEEKQRLEEERRERELQEAARREQRYQEQHRSAGPPSPSSRTGELEQEVVSRSRQEWESAGQQAPHPREIFKQKERAMSTTSVSSSQPGKLRSPFLQKQFTQPEASYGREPTSPVSRPAAGVCEELAPSTPPSAQTDDEPTYEVPSEQETLYEEPPPVQQPGAGSGHIDNYMQSQDLSGQGLCARALYDYQAADDTEISFDPENLITGIEVIDEGWWRGYGPDGHFGMFPANYVELIE
uniprot
proteins
function
FUNCTION: Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Required for the formation of organized podosome rosettes. May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse that regulates T-cell activation by bridging TCRs and the actin cytoskeleton to gene activation and endocytic processes (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G-actin and promote actin polymerization by itself. {ECO:0000250, ECO:0000269|PubMed:11309416, ECO:0000269|PubMed:17476322, ECO:0000269|PubMed:17956734, ECO:0000269|PubMed:23223303}.
uniprot
proteins
mass_dalton
48613
uniprot
proteins
protein_family
ABP1 family
uniprot
proteins
pubmed
11309416
uniprot
proteins
pubmed
11595038
uniprot
proteins
pubmed
15014124
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17476322
uniprot
proteins
pubmed
17956734
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23223303
uniprot
proteins
sequence_length
436
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23223303}. Cell projection, lamellipodium {ECO:0000269|PubMed:23223303}. Cell projection, ruffle {ECO:0000269|PubMed:23223303}. Cytoplasm, cell cortex {ECO:0000269|PubMed:23223303}. Cytoplasm, cytosol {ECO:0000269|PubMed:23223303}. Cell membrane {ECO:0000269|PubMed:23223303}; Peripheral membrane protein; Cytoplasmic side. Synapse {ECO:0000269|PubMed:15014124}. Perikaryon {ECO:0000250|UniProtKB:Q62418}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q62418}. Cell projection, dendrite {ECO:0000269|PubMed:15014124}. Postsynaptic density {ECO:0000269|PubMed:15014124}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q62418}; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:Q62418}; Peripheral membrane protein; Cytoplasmic side. Cell projection, podosome {ECO:0000250|UniProtKB:Q62418}. Early endosome {ECO:0000250|UniProtKB:Q9UJU6}. Note=Associates with lamellipodial actin and membrane ruffles. Colocalizes with actin and cortactin at podosome dots and podosome rosettes. {ECO:0000269|PubMed:23223303}.
uniprot
proteins