Gabra3
entrez
14396
canonical
uniprot
P26049
canonical
ensembl
ENSMUSG00000031343
resolver
ensp
ENSMUSP00000062638
resolver
ensp
ENSMUSP00000272358
resolver
ensp
ENSMUSP00000272360
resolver
ensp
ENSMUSP00000272366
resolver
enst
ENSMUST00000055966
resolver
genesymbol
Gabra3
resolver
genesymbol_syn
Gabra-3
resolver
uniprot
Q8CAB3
resolver
uniprot_entry
GBRA3_MOUSE
resolver
uniprot_entry
Q8CAB3_MOUSE
resolver
amino_acid_sequence
MIITQMWHFYVTRVVLLLLISILPGTTSQGESRRQEPGDFVKQDIGGLSPKHAPDIPDDSTDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDVFFRQTWHDERLKFDGPMKILPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVDNGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTKAEVIYSWTLGKNKSVEVAQDGSRLNQYDLLGHVVGTEIIRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRSWAWEGKKVPEALEMKKKTPAAPTKKNTTFNIVGTTYPINLAKDTEFSTISKSAAAPSASSTPTAIASPKATYVQDSPAETKTYNSVSKVDKISRIIFPVLFAIFNLVYWATYVNRESAIKGMIRKQ
uniprot
proteins
function
FUNCTION: Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (By similarity). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). {ECO:0000250|UniProtKB:P14867, ECO:0000250|UniProtKB:P34903}.
uniprot
proteins
mass_dalton
55398
uniprot
proteins
protein_family
GABRA3 sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
11528422
uniprot
proteins
pubmed
1356407
uniprot
proteins
pubmed
17369310
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
492
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:P14867}; Multi-pass membrane protein. Cell membrane {ECO:0000250|UniProtKB:P14867}; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 275..295; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 306..325; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 337..357; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 458..478; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins