P97687
uniprot
P97687
canonical
amino_acid_sequence
MEDIKDSKVKRFCSKNILIILGFSSVLAVIALIAVGLTHNKPLPENVKYGIVLDAGSSHTNLYIYKWPAEKENDTGVVQLLEECQVKGPGISKYAQKTDEIAAYLAECMKMSTERIPASKQHQTPVYLGATAGMRLLRMESKQSADEVLAAVSRSLKSYPFDFQGAKIITGQEEGAYGWITINYLLGRFTQEQSWLNFISDSQKQATFGALDLGGSSTQVTFVPLNQTLEAPETSLQFRLYGTDYTVYTHSFLCYGKDQALWQKLAQDIQVSSGGILKDPCFYPGYKKVVNVSELYGTPCTKRFEKKLPFNQFQVQGTGDYEQCHQSILKFFNNSHCPYSQCAFNGVFLPPLQGSFGAFSAFYFVMDFFKKMANDSVSSQEKMTEITKNFCSKPWEEVKASYPTVKEKYLSEYCFSGTYILSLLLQGYNFTGTSWDQIHFMGKIKDSNAGWTLGYMLNLTNMIPAEQPLSPPLPHSTYISLMVLFSLVLVAMVITGLFIFSKPSYFWKEAV
uniprot
proteins
ec_number
3.6.1.5
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of nucleoside triphosphates (NTPs) and diphosphates (NDPs) (PubMed:22100451, PubMed:9221928, PubMed:9364474). The enzyme sequentially removes phosphate groups in two successive steps, converting NTPs to nucleoside monophosphates (NMPs) via NDP intermediates (PubMed:22100451, PubMed:9221928, PubMed:9364474). This activity contributes to the regulation of extracellular levels of nucleotides (PubMed:22100451, PubMed:9221928, PubMed:9364474). By hydrolyzing proinflammatory ATP and platelet-activating ADP to AMP, it blocks platelet aggregation and supports blood flow (By similarity). {ECO:0000250|UniProtKB:P49961, ECO:0000269|PubMed:22100451, ECO:0000269|PubMed:9221928, ECO:0000269|PubMed:9364474}.
uniprot
proteins
mass_dalton
57408
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:9221928}.; PTM: The N-terminus is blocked. {ECO:0000250|UniProtKB:P49961}.; PTM: Palmitoylated on Cys-13; which is required for caveola targeting. {ECO:0000250|UniProtKB:P49961}.
uniprot
proteins
protein_family
GDA1/CD39 NTPase family
uniprot
proteins
pubmed
22100451
uniprot
proteins
pubmed
9221928
uniprot
proteins
pubmed
9364474
uniprot
proteins
sequence_length
511
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P49961}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P49961}. Membrane, caveola {ECO:0000250|UniProtKB:P49961}.
uniprot
proteins
transmembrane_region
TRANSMEM 17..37; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 479..499; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins