Hacd4
entrez
66775
canonical
uniprot
A2AKM2
canonical
ensembl
ENSMUSG00000028497
resolver
ensp
ENSMUSP00000030221
resolver
ensp
ENSMUSP00000211404
resolver
ensp
ENSMUSP00000211405
resolver
ensp
ENSMUSP00000211406
resolver
ensp
ENSMUSP00000351983
resolver
ensp
ENSMUSP00000351984
resolver
genesymbol
Hacd4
resolver
genesymbol_syn
Ptplad2
resolver
uniprot
A2AKM1
resolver
uniprot
Q8BG85
resolver
uniprot
Q9CPS2
resolver
uniprot_entry
HACD4_MOUSE
resolver
uniprot_sec
A2AKM1
resolver
uniprot_sec
Q8BG85
resolver
uniprot_sec
Q9CPS2
resolver
amino_acid_sequence
MGPSVLPAWLQPRYRKNVYLFIYYLIQFCGHSWILANMTVRFFSFGKDSMADTFYAIGLVMRVCQSISLLELLHIYIGIESNQLFPRFLQLTERVIILFGVITSQEEVQEKCVVCVLFILWNLLDMVRYTYSMLSVIGTSYAALTWLSQTLWMPIYPLCVLAEAFTIYQSLPYFESFGTNSTVLPFDLSTCFPYVLKLYLMMLFIGMYFTYSHLYTERKDFLRVFSVKQKNV
uniprot
proteins
ec_number
4.2.1.134
uniprot
proteins
function
FUNCTION: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. {ECO:0000250|UniProtKB:Q5VWC8}.
uniprot
proteins
mass_dalton
27235
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000250|UniProtKB:Q5VWC8}.
uniprot
proteins
protein_family
Very long-chain fatty acids dehydratase HACD family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
232
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q5VWC8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5VWC8}.
uniprot
proteins
transmembrane_region
TRANSMEM 20..40; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 57..77; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 113..133; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 136..156; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 158..178; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 190..210; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins