Iws1
entrez
291705
canonical
uniprot
Q3SWT4
canonical
ensembl
ENSRNOG00000014630
resolver
ensembl
ENSRNOG00055025752
resolver
ensembl
ENSRNOG00060028060
resolver
ensembl
ENSRNOG00065012356
resolver
ensp
ENSRNOP00000057730
resolver
ensp
ENSRNOP00000069847
resolver
ensp
ENSRNOP00000085053
resolver
ensp
ENSRNOP00000091736
resolver
ensp
ENSRNOP00055036370
resolver
ensp
ENSRNOP00060040728
resolver
ensp
ENSRNOP00065015446
resolver
enst
ENSRNOT00000061011
resolver
enst
ENSRNOT00000085516
resolver
enst
ENSRNOT00000102322
resolver
enst
ENSRNOT00000112252
resolver
enst
ENSRNOT00055044462
resolver
enst
ENSRNOT00060048817
resolver
enst
ENSRNOT00065020129
resolver
genesymbol
Iws1
resolver
genesymbol_syn
Iws1l
resolver
uniprot
A0A0G2JWE3
resolver
uniprot
A0A8I6A2E0
resolver
uniprot
A0A8I6AF19
resolver
uniprot_entry
A0A0G2JWE3_RAT
resolver
uniprot_entry
A0A8I6A2E0_RAT
resolver
uniprot_entry
A0A8I6AF19_RAT
resolver
uniprot_entry
IWS1_RAT
resolver
amino_acid_sequence
MDSEYYSGDQSDDGGATPVQDERDSGSDGEDDVNEQHSGSDTGSVDRHSENETSDREDGLTKIHNGTDSENDEPSNVHASDSESEELHRPKDSDSESEEHAESPASDSENEAVHQQGSDSEKEELLNGHASDSEKEEGRKHAASDSETEDTLQPQGSESDSEDPPRPQASDSESEEPPKPRISDSESEELPKPRISDSESEDPPRPQVSDSESEELPKPRVSDSESEDPPRPQASDSESEELPKPRVSDSESEDPQKGPASDSEAEDASRHKEKPESEDSDGENKREDSEVQNESDGHADRKGLHSSDSEEEEPKRQKIDSDDDGEKEGDEKVAKRKAAVLSDSEDEDKASAAKKSRVISDADDSDSDVVSDKSGKREKTVASDSEEEVGKEESSVKKSEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEFTGFNQEDLEEEKNETQLKEAEDSDSDDNIKRGKHMDFLSDFEMMLQRKKSMCGKRRRNRDGGTFISDADDVVSAMIVKMNEAAEEDRQLNNQKKPALKKLTLLPTVVMHLKKQDLKETFIDSGVMSAIKEWLSPLPDRSLPALKIREELLKILQELPSVSQETLKHSGIGRAVMYLYKHPKESRSNKDMAGKLINEWSRPIFGLTSNYKGMTREEREQRDLEQMPQRRRMSSTGGQTPRRDLEKVLTGEEKALRPGDPGFCARARVPMPSNKDYVVRPKWNVEMESSRPGILKKGLSRLEKHKRRFAEQKRLSQMHRAVKFSIEGNRMPL
uniprot
proteins
function
FUNCTION: Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
85448
uniprot
proteins
post_translational_modification
PTM: Phosphorylation increases its interaction with PSIP1. {ECO:0000250|UniProtKB:Q96ST2}.
uniprot
proteins
protein_family
IWS1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
764
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00649}.
uniprot
proteins