Slc2a8
entrez
85256
canonical
uniprot
Q9JJZ1
canonical
ensembl
ENSRNOG00000022274
resolver
ensembl
ENSRNOG00065026257
resolver
ensp
ENSRNOP00000022326
resolver
ensp
ENSRNOP00065037167
resolver
enst
ENSRNOT00000022327
resolver
enst
ENSRNOT00065045322
resolver
genesymbol
Slc2a8
resolver
genesymbol_syn
Glut8
resolver
genesymbol_syn
Glutx1
resolver
uniprot
Q9JMA6
resolver
uniprot_entry
SL2A8_RAT
resolver
uniprot_sec
Q9JMA6
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by cytochalasin B. {ECO:0000269|PubMed:10671487}.
uniprot
proteins
amino_acid_sequence
MSPEDPQETQPLLRSPGARAPGGRRVFLATFAAALGPLSFGFALGYSSPAIPSLRRTAPPALRLGDTAASWFGAVVTLGAAAGGVLGGWLLDRAGRKLSLLLCTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILLAYVAGWVLEWRWLAVLGCVPPTLMLLLMCYMPETPRFLLTQHQYQEAMAALRFLWGSEEGWEEPPVGAEHQGFQLAMLRRPGVHKPLIIGICLMVFQQLSGVNAIMFYANTIFEEAKFKDSSLASVTVGIIQVLFTAVAALIMDRAGRKLLLALSGVIMVFSMSAFGTYFKLTQSGPSNSSHVGLLVPISAEPADVHLGLAWLAVGSMCLFIAGFAVGWGPIPWLLMSEIFPLHIKGVATGVCVLTNWFMAFLVTKEFNSIMEILRPYGAFWLTAAFCILSVLFTLTFVPETKGRTLEQITAHFEGR
uniprot
proteins
function
FUNCTION: Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose (PubMed:10671487). Facilitates hepatic influx of dietary trehalose, which in turn inhibits glucose and fructose influx triggering a starvation signal and hepatic autophagy through activation of AMPK and ULK1. Also able to mediate the transport of dehydroascorbate (PubMed:23396969). {ECO:0000269|PubMed:10671487, ECO:0000269|PubMed:23396969}.
uniprot
proteins
mass_dalton
51459
uniprot
proteins
mutagenesis
MUTAGEN 12..13; /note="LL->AA: Changes subcellular location mainly to the plasma membrane, thereby increasing transport activity."; /evidence="ECO:0000269|PubMed:10671487
uniprot
proteins
protein_family
Glucose transporter subfamily
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Sugar transporter (TC 2.A.1.1) family
uniprot
proteins
pubmed
10671487
uniprot
proteins
pubmed
10821868
uniprot
proteins
pubmed
23396969
uniprot
proteins
sequence_length
478
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10671487}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:10671487}; Multi-pass membrane protein {ECO:0000255}. Note=Principally intracellular (PubMed:10671487). May move between intracellular vesicles and the plasma membrane (PubMed:10671487). The dileucine internalization motif is critical for intracellular sequestration (PubMed:10671487). {ECO:0000269|PubMed:10671487}.
uniprot
proteins
transmembrane_region
TRANSMEM 26..46; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 71..91; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 97..117; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 128..148; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 157..177; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 183..203; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 258..278; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 294..314; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 321..341; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 369..389; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 406..426; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 440..460; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins