Pi4k2a
entrez
114554
canonical
uniprot
Q99M64
canonical
ensembl
ENSRNOG00000014675
resolver
ensembl
ENSRNOG00055003993
resolver
ensembl
ENSRNOG00060028264
resolver
ensembl
ENSRNOG00065028245
resolver
ensp
ENSRNOP00000094624
resolver
ensp
ENSRNOP00055004859
resolver
ensp
ENSRNOP00060040998
resolver
ensp
ENSRNOP00065039886
resolver
enst
ENSRNOT00000095169
resolver
enst
ENSRNOT00055006365
resolver
enst
ENSRNOT00060049119
resolver
enst
ENSRNOT00065048649
resolver
genesymbol
Pi4k2a
resolver
genesymbol_syn
Pi4kii
resolver
uniprot
A0A8I6GL94
resolver
uniprot_entry
A0A8I6GL94_RAT
resolver
uniprot_entry
P4K2A_RAT
resolver
amino_acid_sequence
MDETSPLVSPERAQPPEYTFPSVSGAHFPQVPGGAVRVAAAGSGPSPPCSPGHDRERQPLLDRARGAAAQGQTHTVAAQAQALAAQAAVAVHAVQTHRERNDFPEDPEFEVVVRQAEIAIECSIYPERIYQGSSGSYFVKDSQGRIIAVFKPKNEEPYGNLNPKWTKWLQKLCCPCCFGRDCLVLNQGYLSEAGASLVDQKLELNIVPRTKVVYLASETFNYSAIDRVKSRGKRLALEKVPKVGQRFNRIGLPPKVGSFQLFVEGYKDADYWLRRFEAEPLPENTNRQLLLQFERLVVLDYIIRNTDRGNDNWLIKYDYPMDNPNCRDTDWVMVREPVIKVAAIDNGLAFPLKHPDSWRAYPFYWAWLPQAKVPFSQEIKDLILPKISDPNFVKDLEEDLYELFKKDPGFDRGQFHKQIAVMRGQILNLTQALKDNKSPLHLVQMPPVIVETARSHQRSSSESYTQSFQSRKPFFSWW
uniprot
proteins
ec_number
2.7.1.67
uniprot
proteins
function
FUNCTION: Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). {ECO:0000269|PubMed:11244087, ECO:0000305}.
uniprot
proteins
mass_dalton
54305
uniprot
proteins
mutagenesis
MUTAGEN 60; /note="L->A: Reduces targeting to synaptic vesicles and neurite tips; when associated with A-61."; /evidence="ECO:0000269|PubMed:21998198"; MUTAGEN 61; /note="L->A: Reduces targeting to synaptic vesicles and neurite tips; when associated with A-60."; /evidence="ECO:0000269|PubMed:21998198
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by ITCH; this does not lead to proteasomal degradation. {ECO:0000250|UniProtKB:Q9BTU6}.; PTM: Palmitoylated (PubMed:11244087). Palmitoylated by ZDHHC3 and ZDHHC7 in the CCPCC motif. Palmitoylation is cholesterol-dependent, and required for TGN localization (By similarity). {ECO:0000250|UniProtKB:Q9BTU6, ECO:0000269|PubMed:11244087}.
uniprot
proteins
protein_family
PI3/PI4-kinase family
uniprot
proteins
protein_family
Type II PI4K subfamily
uniprot
proteins
pubmed
11244087
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
19581584
uniprot
proteins
pubmed
21998198
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
478
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q9BTU6}; Lipid-anchor {ECO:0000250|UniProtKB:Q9BTU6}. Membrane raft {ECO:0000250|UniProtKB:Q9BTU6}. Endosome {ECO:0000269|PubMed:21998198}. Endosome membrane {ECO:0000250|UniProtKB:Q9BTU6}. Cytoplasmic vesicle {ECO:0000269|PubMed:21998198}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q2TBE6}. Presynaptic cell membrane {ECO:0000250|UniProtKB:Q2TBE6}. Synapse, synaptosome {ECO:0000250|UniProtKB:Q2TBE6}. Mitochondrion {ECO:0000250|UniProtKB:Q2TBE6}. Membrane {ECO:0000269|PubMed:11244087}; Lipid-anchor {ECO:0000269|PubMed:11244087}. Cell membrane {ECO:0000250|UniProtKB:Q9BTU6}. Perikaryon {ECO:0000250|UniProtKB:Q2TBE6}. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q2TBE6}. Note=Found in subdomains of the plasma membrane termed non-caveolar membrane rafts. Transported from neuronal cell body to neuron projections and neurite tips in a BLOC-1- and AP-3-complexes-dependent manner. {ECO:0000250|UniProtKB:Q2TBE6}.
uniprot
proteins