Srgn
entrez
56782
canonical
uniprot
P04917
canonical
ensembl
ENSRNOG00055014595
resolver
ensembl
ENSRNOG00060007557
resolver
ensembl
ENSRNOG00065003298
resolver
ensp
ENSRNOP00055020462
resolver
ensp
ENSRNOP00060009431
resolver
ensp
ENSRNOP00065003366
resolver
enst
ENSRNOT00055025032
resolver
enst
ENSRNOT00060012461
resolver
enst
ENSRNOT00065004702
resolver
genesymbol
Srgn
resolver
genesymbol_syn
Pgsg
resolver
genesymbol_syn
Prg
resolver
genesymbol_syn
Prg1
resolver
uniprot_entry
SRGN_RAT
resolver
amino_acid_sequence
MRQVPVGTRLVLALAFVLVWGSSVQGYPARRARYQWVRCKPDGIFANCIEEKGPRFDLIAEESNVGPPMTDPVLMRGFPNDFFPISDDYSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSGSLADMEWEYQPTDENNIVYFNYGPFDRMLTEQNQEQPGDFII
uniprot
proteins
function
FUNCTION: Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF and may also regulate protease secretion. Inhibits bone mineralization (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
18577
uniprot
proteins
post_translational_modification
PTM: O-glycosylated; contains chondroitin sulfate and heparan sulfate. {ECO:0000250}.
uniprot
proteins
protein_family
Serglycin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2352541
uniprot
proteins
pubmed
2427521
uniprot
proteins
pubmed
3366780
uniprot
proteins
pubmed
3919394
uniprot
proteins
sequence_length
179
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic granule {ECO:0000250|UniProtKB:P10124}. Cytolytic granule {ECO:0000250|UniProtKB:P10124}. Secreted, extracellular space {ECO:0000250|UniProtKB:P10124}. Golgi apparatus {ECO:0000250|UniProtKB:P10124}. Note=Found in mast cell granules and in cytoplasmic granules of cytolytic T-lymphocytes from where it is secreted upon cell activation. Secreted constitutively by endothelial cells and macrophages. Located to Golgi apparatus during neutrophil differentiation (By similarity). {ECO:0000250|UniProtKB:P10124, ECO:0000250|UniProtKB:P13609}.
uniprot
proteins