Cd72
entrez
12517
canonical
uniprot
P21855
canonical
ensembl
ENSMUSG00000028459
resolver
ensp
ENSMUSP00000030179
resolver
ensp
ENSMUSP00000095708
resolver
ensp
ENSMUSP00000095709
resolver
ensp
ENSMUSP00000103558
resolver
ensp
ENSMUSP00000103559
resolver
ensp
ENSMUSP00000195674
resolver
ensp
ENSMUSP00000350147
resolver
enst
ENSMUST00000030179
resolver
enst
ENSMUST00000098104
resolver
enst
ENSMUST00000098105
resolver
enst
ENSMUST00000107925
resolver
enst
ENSMUST00000107926
resolver
genesymbol
Cd72
resolver
genesymbol_syn
Ly-32
resolver
genesymbol_syn
Ly32
resolver
genesymbol_syn
Lyb-2
resolver
uniprot
A2AIN5
resolver
uniprot
A2AIN6
resolver
uniprot
F6T7G4
resolver
uniprot
F6WGI1
resolver
uniprot
F6WGK4
resolver
uniprot
Q3UB58
resolver
uniprot
Q3UNJ0
resolver
uniprot
Q3UZ35
resolver
uniprot
Q64225
resolver
uniprot_entry
A2AIN5_MOUSE
resolver
uniprot_entry
CD72_MOUSE
resolver
uniprot_entry
F6T7G4_MOUSE
resolver
uniprot_entry
F6WGI1_MOUSE
resolver
uniprot_entry
F6WGK4_MOUSE
resolver
uniprot_entry
Q3UB58_MOUSE
resolver
uniprot_entry
Q3UNJ0_MOUSE
resolver
uniprot_entry
Q3UZ35_MOUSE
resolver
uniprot_sec
A2AIN6
resolver
uniprot_sec
Q64225
resolver
amino_acid_sequence
MADAITYADLRFVKVPLKNSASNHLGQDCEAYEDGELTYENVQVSPVPGGPPGLASPALADKAGVGSEQPTATWSSVNSSALRQIPRCPTVCLQYFLLGLLVSCLMLGVAVICLGVRYLQVSRQFQEGTRIWEATNSSLQQQLREKISQLGQKEVELQKARKELISSQDTLQEKQRTHEDAEQQLQACQAERAKTKENLKTEEERRRDLDQRLTSTRETLRRFFSDSSDTCCPCGWIPYQERCFYISHTLGSLEESQKYCTSLSSKLAAFDEPSKYYYEVSLPSGLEELLDRSKSYWIQMSKKWRQDSDSQSRHCVRIKTYYQKWERTISKCAELHPCICESEAFRFPDGINLN
uniprot
proteins
function
FUNCTION: Co-receptor of B cell receptor (BCR) that plays both positive and negative roles on B-cell functions (PubMed:10549631). Recognizes the Sm/ribonucleoprotein (RNP) self-antigen ligand, and coligation of CD72 and BCR inhibits BCR signaling (PubMed:27810925). Mechanistically, ligand binding leads to the recruitment of PTPN6/SHP-1 to the BCR complex which is inhibitory to BCR signaling (PubMed:9590210). Acts also as a ligand for CD5 and thereby plays a critical role in maintaining regulatory T and B-cell homeostasis (PubMed:24950378, PubMed:9723705). {ECO:0000269|PubMed:10549631, ECO:0000269|PubMed:24950378, ECO:0000269|PubMed:27810925, ECO:0000269|PubMed:9590210, ECO:0000269|PubMed:9723705}.
uniprot
proteins
mass_dalton
40347
uniprot
proteins
post_translational_modification
PTM: Phosphorylated upon engagement of the B-cell receptor, probably by LYN or SYK. Phosphorylation at Tyr-7 is important for interaction with PTPN6/SHP-1. {ECO:0000269|PubMed:9590210}.
uniprot
proteins
pubmed
10549631
uniprot
proteins
pubmed
1634777
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24950378
uniprot
proteins
pubmed
2645579
uniprot
proteins
pubmed
27810925
uniprot
proteins
pubmed
9590210
uniprot
proteins
pubmed
9723705
uniprot
proteins
sequence_length
354
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 96..116; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins