KIN
entrez
22944
canonical
uniprot
O60870
canonical
ensembl
ENSG00000151657
resolver
ensp
ENSP00000368881
resolver
genesymbol
KIN
resolver
genesymbol_syn
BTCD
resolver
genesymbol_syn
KIN17
resolver
hgnc
HGNC:6327
resolver
uniprot
B4DX32
resolver
uniprot_entry
KIN17_HUMAN
resolver
uniprot_sec
B4DX32
resolver
amino_acid_sequence
MGKSDFLTPKAIANRIKSKGLQKLRWYCQMCQKQCRDENGFKCHCMSESHQRQLLLASENPQQFMDYFSEEFRNDFLELLRRRFGTKRVHNNIVYNEYISHREHIHMNATQWETLTDFTKWLGREGLCKVDETPKGWYIQYIDRDPETIRRQLELEKKKKQDLDDEEKTAKFIEEQVRRGLEGKEQEVPTFTELSRENDEEKVTFNLSKGACSSSGATSSKSSTLGPSALKTIGSSASVKRKESSQSSTQSKEKKKKKSALDEIMEIEEEKKRTARTDYWLQPEIIVKIITKKLGEKYHKKKAIVKEVIDKYTAVVKMIDSGDKLKLDQTHLETVIPAPGKRILVLNGGYRGNEGTLESINEKTFSATIVIETGPLKGRRVEGIQYEDISKLA
uniprot
proteins
function
FUNCTION: Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro. {ECO:0000250|UniProtKB:Q8K339, ECO:0000269|PubMed:11880372, ECO:0000269|PubMed:12359749, ECO:0000269|PubMed:12754299, ECO:0000269|PubMed:12853634, ECO:0000269|PubMed:15831485, ECO:0000269|PubMed:17045609}.
uniprot
proteins
mass_dalton
45374
uniprot
proteins
mutagenesis
MUTAGEN 135; /note="K->R: Almost complete loss of in vitro methylation by METTL22."; /evidence="ECO:0000269|PubMed:23349634"; MUTAGEN 302; /note="K->E: Significant reduction of RNA-binding activity."; /evidence="ECO:0000269|PubMed:17045609"; MUTAGEN 391; /note="K->E: Significant reduction of RNA-binding activity."; /evidence="ECO:0000269|PubMed:17045609
uniprot
proteins
protein_family
KIN17 family
uniprot
proteins
pubmed
10964102
uniprot
proteins
pubmed
11880372
uniprot
proteins
pubmed
12359749
uniprot
proteins
pubmed
12525703
uniprot
proteins
pubmed
12754299
uniprot
proteins
pubmed
12853634
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15831485
uniprot
proteins
pubmed
17045609
uniprot
proteins
pubmed
18029424
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23349634
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
9266022
uniprot
proteins
sequence_length
393
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11880372, ECO:0000269|PubMed:12359749, ECO:0000269|PubMed:12754299, ECO:0000269|PubMed:12853634, ECO:0000269|PubMed:15831485}. Cytoplasm {ECO:0000269|PubMed:11880372, ECO:0000269|PubMed:12359749, ECO:0000269|PubMed:12754299, ECO:0000269|PubMed:12853634, ECO:0000269|PubMed:15831485}. Note=During S phase, strongly associated with the nuclear matrix, and to chromosomal DNA in the presence of DNA damage. Also shows cytoplasmic localization in elongated spermatids. {ECO:0000250|UniProtKB:Q8K339, ECO:0000269|PubMed:11880372, ECO:0000269|PubMed:12359749, ECO:0000269|PubMed:12754299, ECO:0000269|PubMed:12853634, ECO:0000269|PubMed:15831485}.
uniprot
proteins