Trip6
entrez
22051
canonical
uniprot
Q9Z1Y4
canonical
ensembl
ENSMUSG00000023348
resolver
ensp
ENSMUSP00000024119
resolver
enst
ENSMUST00000024119
resolver
genesymbol
Trip6
resolver
genesymbol_syn
Zrp1
resolver
uniprot
B2RS30
resolver
uniprot
Q3TX74
resolver
uniprot_entry
B2RS30_MOUSE
resolver
uniprot_entry
TRIP6_MOUSE
resolver
uniprot_sec
Q3TX74
resolver
amino_acid_sequence
MSGPTWLPPKQPEPSRLPQGRSLPRGALGPPTAHGATLQPHPRVNFCPLPPEHCYQPPGVPEDRGPTWVGSHGTPQRLQGLPPDRGIIRPGSLDAEIDSLTSMLADLDGGRSHAPRRPDRQAFEAPPPHAYRGGSLKPSGGAVPTPMLPASHYGGPTPASYATASTPAGPAFPVQVKVAQPVRGCGLPRRGASQASGPLPGPHFPLTGRGEVWGAGYRSHREPGPGVPEGPSGVHIPAGGGRGGGHEPQGPLGQPPEEELERLTKKLVHDMSHPPSGEYFGRCGGCGEDVVGDGAGVVALDRVFHIGCFVCSTCRAQLRGQHFYAVERRAYCESCYVATLEKCSTCSEPILDRILRAMGKAYHPGCFTCVVCHRGLDGIPFTVDATSQIHCIEDFHRKFAPRCSVCGGAIMPEPGQEETVRIVALDRSFHIGCYKCEECGLLLSSEGECQGCYPLDGHILCKACSAWRIQELSATVTTDC
uniprot
proteins
function
FUNCTION: Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these transcription factors induced by glucocorticoid receptor (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
50934
uniprot
proteins
mutagenesis
MUTAGEN 479..480; /note="Missing: Interacts with PDLIM4. Loss of interaction with PTPN13."; /evidence="ECO:0000269|PubMed:10826496
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Tyr-55 by SRC is required for enhancement of lysophosphatidic acid-induced cell migration. Tyr-55 is dephosphorylated by PTPN13 (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Zyxin/ajuba family
uniprot
proteins
pubmed
10395914
uniprot
proteins
pubmed
10826496
uniprot
proteins
pubmed
11239002
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17095609
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
480
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q15654}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q15654}. Nucleus {ECO:0000250|UniProtKB:Q15654}. Cytoplasm {ECO:0000250|UniProtKB:Q15654}. Note=Shuttles between nucleus and cytoplasm. Colocalizes with actin. {ECO:0000250|UniProtKB:Q15654}.
uniprot
proteins