Ptdss1
entrez
19210
canonical
uniprot
Q99LH2
canonical
ensembl
ENSMUSG00000021518
resolver
ensp
ENSMUSP00000021990
resolver
enst
ENSMUST00000021990
resolver
genesymbol
Ptdss1
resolver
genesymbol_syn
Pssa
resolver
uniprot
O55024
resolver
uniprot
Q3UV14
resolver
uniprot
Q8C2S8
resolver
uniprot_entry
PTSS1_MOUSE
resolver
uniprot_sec
O55024
resolver
uniprot_sec
Q3UV14
resolver
uniprot_sec
Q8C2S8
resolver
activity_regulation
ACTIVITY REGULATION: Potently inhibited by choline in the mitochondria-associated membrane (MAM). Very little inhibition by choline in the endoplasmic reticulum (ER) per se. {ECO:0000269|PubMed:10938271}.
uniprot
proteins
amino_acid_sequence
MASCVGSRTLSKDDVNYRMHFRMINEQQVEDITIDFFYRPHTITLLSFTIISLMYFAFTRDDSVPEDNIWRGILSVIFFFLIISVLAFPNGPFTRPHPALWRMVFGLSVLYFLFLVFLLFLNFEQVKSLMYWLDPNLRYATREADIMEYAVNCHVITWERIVSHFDIFAFGHFWGWAMKALLIRSYGLCWTISITWELTELFFMHLLPNFAECWWDQVILDILLCNGGGIWLGMVVCRFLEMRTYHWASFKDIHTTTGKIKRAVLQFTPASWTYVRWFDPKSSFQRVAGIYLFMIIWQLTELNTFFLKHIFVFQASHPLSWGRILFIGCITAPTVRQYYAYLTDTQCKRVGTQCWVFGVIGFLEAIVCIKFGQDLFSKTQILYVMLWLLCVAFTTFLCLYGMVWYAEHYGHREKTYSECEDGTYSPEISWHHGKGSKGSEDSPPKHSSNHESHSSRRRNRHSKSKVTNGVGKK
uniprot
proteins
ec_number
2.7.8.29
uniprot
proteins
function
FUNCTION: Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine (PubMed:10432300, PubMed:10938271, PubMed:18343815, PubMed:9516423). Catalyzes mainly the conversion of phosphatidylcholine (PubMed:10432300, PubMed:10938271, PubMed:18343815, PubMed:9516423). Also converts, in vitro and to a lesser extent, phosphatidylethanolamine (PubMed:10432300, PubMed:10938271, PubMed:18343815, PubMed:9516423). {ECO:0000269|PubMed:10432300, ECO:0000269|PubMed:10938271, ECO:0000269|PubMed:18343815, ECO:0000269|PubMed:9516423}.
uniprot
proteins
mass_dalton
55604
uniprot
proteins
pathway_participation
PATHWAY: Phospholipid metabolism; phosphatidylserine biosynthesis.
uniprot
proteins
protein_family
Phosphatidyl serine synthase family
uniprot
proteins
pubmed
10432300
uniprot
proteins
pubmed
10938271
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18343815
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9516423
uniprot
proteins
sequence_length
473
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10938271}; Multi-pass membrane protein {ECO:0000269|PubMed:10938271}. Note=Highly enriched in the mitochondria-associated membrane (MAM).
uniprot
proteins
transmembrane_region
TRANSMEM 36..56; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 73..93; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 103..123; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 187..207; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 217..237; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 287..307; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 320..342; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 356..376; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 384..404; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins