LZTS2
entrez
84445
canonical
uniprot
Q9BRK4
canonical
ensembl
ENSG00000107816
resolver
ensp
ENSP00000359240
resolver
ensp
ENSP00000359243
resolver
ensp
ENSP00000416972
resolver
ensp
ENSP00000523740
resolver
ensp
ENSP00000523741
resolver
ensp
ENSP00000523761
resolver
ensp
ENSP00000523762
resolver
ensp
ENSP00000523763
resolver
ensp
ENSP00000523764
resolver
ensp
ENSP00000523765
resolver
ensp
ENSP00000523766
resolver
ensp
ENSP00000582502
resolver
ensp
ENSP00000582503
resolver
ensp
ENSP00000582504
resolver
ensp
ENSP00000582505
resolver
ensp
ENSP00000582506
resolver
ensp
ENSP00000582507
resolver
ensp
ENSP00000582508
resolver
ensp
ENSP00000582510
resolver
ensp
ENSP00000633054
resolver
ensp
ENSP00000633055
resolver
enst
ENST00000370220
resolver
enst
ENST00000370223
resolver
enst
ENST00000454422
resolver
enst
ENST00000853681
resolver
enst
ENST00000853682
resolver
enst
ENST00000853703
resolver
enst
ENST00000853705
resolver
enst
ENST00000853707
resolver
enst
ENST00000912443
resolver
enst
ENST00000912444
resolver
enst
ENST00000912445
resolver
enst
ENST00000912446
resolver
enst
ENST00000912447
resolver
enst
ENST00000912448
resolver
enst
ENST00000912449
resolver
enst
ENST00000912451
resolver
enst
ENST00000962996
resolver
genesymbol
LZTS2
resolver
genesymbol_syn
KIAA1813
resolver
genesymbol_syn
LAPSER1
resolver
hgnc
HGNC:29381
resolver
uniprot
B1AL14
resolver
uniprot
B4DP66
resolver
uniprot
D3DR72
resolver
uniprot
Q8N3I0
resolver
uniprot
Q96J79
resolver
uniprot
Q96JL2
resolver
uniprot_entry
B4DP66_HUMAN
resolver
uniprot_entry
LZTS2_HUMAN
resolver
uniprot_sec
B1AL14
resolver
uniprot_sec
D3DR72
resolver
uniprot_sec
Q8N3I0
resolver
uniprot_sec
Q96J79
resolver
uniprot_sec
Q96JL2
resolver
amino_acid_sequence
MAIVQTLPVPLEPAPEAATAPQAPVMGSVSSLISGRPCPGGPAPPRHHGPPGPTFFRQQDGLLRGGYEAQEPLCPAVPPRKAVPVTSFTYINEDFRTESPPSPSSDVEDAREQRAHNAHLRGPPPKLIPVSGKLEKNMEKILIRPTAFKPVLPKPRGAPSLPSFMGPRATGLSGSQGSLTQLFGGPASSSSSSSSSSAADKPLAFSGWASGCPSGTLSDSGRNSLSSLPTYSTGGAEPTTSSPGGHLPSHGSGRGALPGPARGVPTGPSHSDSGRSSSSKSTGSLGGRVAGGLLGSGTRASPDSSSCGERSPPPPPPPPSDEALLHCVLEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGLAEQAPCICLEEITATEI
uniprot
proteins
function
FUNCTION: Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. {ECO:0000255|HAMAP-Rule:MF_03026, ECO:0000269|PubMed:17000760, ECO:0000269|PubMed:17351128, ECO:0000269|PubMed:17950943, ECO:0000269|PubMed:18490357}.
uniprot
proteins
mass_dalton
72759
uniprot
proteins
mutagenesis
MUTAGEN 638; /note="L->A: Induces nuclear accumulation. Impairs nuclear exclusion of beta-catenin; when associated with A-640."; /evidence="ECO:0000269|PubMed:17000760"; MUTAGEN 640; /note="L->A: Induces nuclear accumulation. Impairs nuclear exclusion of beta-catenin; when associated with A-38."; /evidence="ECO:0000269|PubMed:17000760
uniprot
proteins
protein_family
LZTS2 family
uniprot
proteins
pubmed
11347906
uniprot
proteins
pubmed
11709705
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17000760
uniprot
proteins
pubmed
17351128
uniprot
proteins
pubmed
17950943
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18490357
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
669
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Localized to the centrosome throughout the cell cycle. Localized to the midbody in cells undergoing cytokinesis.
uniprot
proteins