Cacng8
entrez
140729
canonical
uniprot
Q8VHW5
canonical
ensembl
ENSRNOG00000057848
resolver
ensembl
ENSRNOG00055031010
resolver
ensembl
ENSRNOG00060025066
resolver
ensembl
ENSRNOG00065030579
resolver
ensp
ENSRNOP00000075354
resolver
ensp
ENSRNOP00055044504
resolver
ensp
ENSRNOP00060035910
resolver
ensp
ENSRNOP00065043311
resolver
enst
ENSRNOT00000078444
resolver
enst
ENSRNOT00055053785
resolver
enst
ENSRNOT00060043356
resolver
enst
ENSRNOT00065052689
resolver
genesymbol
Cacng8
resolver
uniprot_entry
CCG8_RAT
resolver
amino_acid_sequence
MESLKRWNEERGLWCEKGVQVLLTTIGAFAAFGLMTIAISTDYWLYTRALICNTTNLTAGDDGPPHRGGSGSSEKKDPGGLTHSGLWRICCLEGLKRGVCVKINHFPEDTDYDHDSAEYLLRVVRASSIFPILSAILLLLGGVCVAASRVYKSKRNIILGAGILFVAAGLSNIIGVIVYISANAGEPGPKRDEEKKNHYSYGWSFYFGGLSFILAEVIGVLAVNIYIERSREAHCQSRSDLLKAGGGAGGSGGSGPSAILRLPSYRFRYRRRSRSSSRGSSEASPSRDASPGGPGGPGFASTDISMYTLSRDPSKGSVAAGLASAGGGGGGAGVGAYGGAAGAAGGGGTGSERDRGSSAGFLTLHNAFPKEAASGVTVTVTGPPAAPAPAPPAPAAPAPGTLSKEAAASNTNTLNRKTTPV
uniprot
proteins
function
FUNCTION: Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. {ECO:0000250|UniProtKB:Q8VHW2, ECO:0000269|PubMed:17880894, ECO:0000269|PubMed:19234459}.
uniprot
proteins
mass_dalton
43269
uniprot
proteins
post_translational_modification
PTM: Palmitoylated (PubMed:23687301). Probably palmitoylated by ZDHHC3 and ZDHHC7 (PubMed:23687301). {ECO:0000269|PubMed:23687301}.
uniprot
proteins
protein_family
CACNG subfamily
uniprot
proteins
protein_family
PMP-22/EMP/MP20 family
uniprot
proteins
pubmed
11738816
uniprot
proteins
pubmed
17880894
uniprot
proteins
pubmed
19234459
uniprot
proteins
pubmed
19265014
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23687301
uniprot
proteins
sequence_length
421
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8VHW2}; Multi-pass membrane protein {ECO:0000305}. Postsynaptic density membrane {ECO:0000250|UniProtKB:Q8VHW2}.
uniprot
proteins
transmembrane_region
TRANSMEM 19..39; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 127..147; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 157..177; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 207..227; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 318..338; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins