CENPI
entrez
2491
canonical
uniprot
Q92674
canonical
ensembl
ENSG00000102384
resolver
ensp
ENSP00000362017
resolver
ensp
ENSP00000399274
resolver
ensp
ENSP00000507595
resolver
ensp
ENSP00000507927
resolver
ensp
ENSP00000577160
resolver
ensp
ENSP00000577161
resolver
ensp
ENSP00000603841
resolver
ensp
ENSP00000603842
resolver
ensp
ENSP00000603843
resolver
ensp
ENSP00000785565
resolver
enst
ENST00000423383
resolver
enst
ENST00000933783
resolver
enst
ENST00000933784
resolver
genesymbol
CENPI
resolver
genesymbol_syn
FSHPRH1
resolver
genesymbol_syn
ICEN19
resolver
genesymbol_syn
LRPR1
resolver
hgnc
HGNC:3968
resolver
uniprot
A0A8C8KX99
resolver
uniprot
B4DZL4
resolver
uniprot
Q5JWZ9
resolver
uniprot
Q96ED0
resolver
uniprot_entry
A0A8C8KX99_HUMAN
resolver
uniprot_entry
B4DZL4_HUMAN
resolver
uniprot_entry
CENPI_HUMAN
resolver
uniprot_sec
Q5JWZ9
resolver
uniprot_sec
Q96ED0
resolver
amino_acid_sequence
MSPQKRVKNVQAQNRTSQGSSSFQTTLSAWKVKQDPSNSKNISKHGQNNPVGDYEHADDQAEEDALQMAVGYFEKGPIKASQNKDKTLEKHLKTVENVAWKNGLASEEIDILLNIALSGKFGNAVNTRILKCMIPATVISEDSVVKAVSWLCVGKCSGSTKVLFYRWLVAMFDFIDRKEQINLLYGFFFASLQDDALCPYVCHLLYLLTKKENVKPFRVRKLLDLQAKMGMQPHLQALLSLYKFFAPALISVSLPVRKKIYFKNSENLWKTALLAVKQRNRGPSPEPLKLMLGPANVRPLKRKWNSLSVIPVLNSSSYTKECGKKEMSLSDCLNRSGSFPLEQLQSFPQLLQNIHCLELPSQMGSVLNNSLLLHYINCVRDEPVLLRFYYWLSQTLQEECIWYKVNNYEHGKEFTNFLDTIIRAECFLQEGFYSCEAFLYKSLPLWDGLCCRSQFLQLVSWIPFSSFSEVKPLLFDHLAQLFFTSTIYFKCSVLQSLKELLQNWLLWLSMDIHMKPVTNSPLETTLGGSMNSVSKLIHYVGWLSTTAMRLESNNTFLLHFILDFYEKVCDIYINYNLPLVVLFPPGIFYSALLSLDTSILNQLCFIMHRYRKNLTAAKKNELVQKTKSEFNFSSKTYQEFNHYLTSMVGCLWTSKPFGKGIYIDPEILEKTGVAEYKNSLNVVHHPSFLSYAVSFLLQESPEERTVNVSSIRGKKWSWYLDYLFSQGLQGLKLFIRSSVHHSSIPRAEGINCNNQY
uniprot
proteins
function
FUNCTION: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone. {ECO:0000269|PubMed:12640463, ECO:0000269|PubMed:16622420}.
uniprot
proteins
mass_dalton
86720
uniprot
proteins
post_translational_modification
PTM: Sumoylated. Sumoylated form can be polyubiquitinated by RNF4, leading to its degradation. Desumoylation by SENP6 prevents its degradation. {ECO:0000269|PubMed:20212317}.
uniprot
proteins
protein_family
CENP-I/CTF3 family
uniprot
proteins
pubmed
12640463
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
16622419
uniprot
proteins
pubmed
16622420
uniprot
proteins
pubmed
16716197
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20212317
uniprot
proteins
pubmed
8921378
uniprot
proteins
sequence_length
756
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
uniprot
proteins