Kcnj5
entrez
16521
canonical
uniprot
P48545
canonical
ensembl
ENSMUSG00000032034
resolver
ensp
ENSMUSP00000034533
resolver
ensp
ENSMUSP00000149000
resolver
ensp
ENSMUSP00000203223
resolver
ensp
ENSMUSP00000203226
resolver
enst
ENSMUST00000034533
resolver
enst
ENSMUST00000214223
resolver
genesymbol
Kcnj5
resolver
genesymbol_syn
Girk4
resolver
uniprot
P97508
resolver
uniprot
Q3TPX9
resolver
uniprot_entry
KCNJ5_MOUSE
resolver
uniprot_sec
P97508
resolver
uniprot_sec
Q3TPX9
resolver
activity_regulation
ACTIVITY REGULATION: Heteromultimer composed of KCNJ3/GIRK1 and KCNJ5/GIRK4 is activated by phosphatidylinositol 4,5 biphosphate (PtdIns(4,5)P2). {ECO:0000250|UniProtKB:P48548}.
uniprot
proteins
amino_acid_sequence
MAGDSRNAMNQDMEIGVTSQDHKKIPKQARDYIPIATDRTRLLTEGKKPRQRYMEKTGKCNVHHGNVQETYRYLSDLFTTLVDLKWRFNLLVFTMVYTITWLFFGFIWWLIAYVRGDLDHVGDQEWIPCVENLSGFVSAFLFSIETETTIGYGFRVITEKCPEGIILLLVQAILGSIVNAFMVGCMFVKISQPKKRAETLMFSNNAVISMRDEKLCLMFRVGDLRNSHIVEASIRAKLIKSRQTKEGEFIPLNQTDINVGFDTGDDRLFLVSPLIISHEINEKSPFWEMSRAQLEQEEFEVVVILEGMVEATGMTCQARSSYMDTEVLWGHRFTPVLTLEKGFYEVDYNTFHDTYETNTPSCCAKELAEMKRSGRLLQYLPSPPLLGGCAEAGNEAEAEKDEEGEPNGLSVSQATRGSM
uniprot
proteins
function
FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium. This potassium channel is controlled by G proteins (By similarity). Forms a functional channel in association with KCNJ3/GIRK1 (PubMed:10341034). {ECO:0000250|UniProtKB:P48544, ECO:0000269|PubMed:10341034}.
uniprot
proteins
mass_dalton
47669
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ5 subfamily
uniprot
proteins
pubmed
10341034
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
7499385
uniprot
proteins
sequence_length
419
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P48544}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 87..111; /note="Helical; Name=M1"; /evidence="ECO:0000250"; TRANSMEM 164..185; /note="Helical; Name=M2"; /evidence="ECO:0000250
uniprot
proteins