Proc
entrez
19123
canonical
uniprot
P33587
canonical
ensembl
ENSMUSG00000024386
resolver
ensp
ENSMUSP00000132226
resolver
ensp
ENSMUSP00000157269
resolver
ensp
ENSMUSP00000222980
resolver
ensp
ENSMUSP00000222984
resolver
enst
ENSMUST00000171765
resolver
enst
ENSMUST00000234651
resolver
genesymbol
Proc
resolver
uniprot
O35498
resolver
uniprot
Q91WN8
resolver
uniprot
Q99PC6
resolver
uniprot_entry
PROC_MOUSE
resolver
uniprot_sec
O35498
resolver
uniprot_sec
Q91WN8
resolver
uniprot_sec
Q99PC6
resolver
amino_acid_sequence
MWQFRVFLLLMSTWGISSIPAHPDPVFSSSEHAHQVLRVRRANSFLEEMRPGSLERECMEEICDFEEAQEIFQNVEDTLAFWIKYFDGDQCSAPPLDHQCDSPCCGHGTCIDGIGSFSCSCDKGWEGKFCQQELRFQDCRVNNGGCLHYCLEESNGRRCACAPGYELADDHMRCKSTVNFPCGKLGRWIEKKRKILKRDTDLEDELEPDPRIVNGTLTKQGDSPWQAILLDSKKKLACGGVLIHTSWVLTAAHCVEGTKKLTVRLGEYDLRRRDHWELDLDIKEILVHPNYTRSSSDNDIALLRLAQPATLSKTIVPICLPNNGLAQELTQAGQETVVTGWGYQSDRIKDGRRNRTFILTFIRIPLVARNECVEVMKNVVSENMLCAGIIGDTRDACDGDSGGPMVVFFRGTWFLVGLVSWGEGCGHTNNYGIYTKVGSYLKWIHSYIGEKGVSLKSQKL
uniprot
proteins
ec_number
3.4.21.69
uniprot
proteins
function
FUNCTION: Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids (By similarity). Exerts a protective effect on the endothelial cell barrier function (By similarity). {ECO:0000250|UniProtKB:P04070}.
uniprot
proteins
mass_dalton
51818
uniprot
proteins
post_translational_modification
PTM: Carboxylated by vitamin K-dependent GGCX to form gamma-carboxyglutamate; these residues are essential for the binding of calcium. {ECO:0000250|UniProtKB:P04070}.; PTM: N- and O-glycosylated (By similarity). {ECO:0000250|UniProtKB:P04070}.; PTM: The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. {ECO:0000250}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1618739
uniprot
proteins
pubmed
16944957
uniprot
proteins
pubmed
8043441
uniprot
proteins
pubmed
9493582
uniprot
proteins
sequence_length
460
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P04070}. Golgi apparatus {ECO:0000250|UniProtKB:P04070}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P04070}.
uniprot
proteins