EREG
entrez
2069
canonical
uniprot
O14944
canonical
ensembl
ENSG00000124882
resolver
ensp
ENSP00000244869
resolver
enst
ENST00000244869
resolver
genesymbol
EREG
resolver
hgnc
HGNC:3443
resolver
uniprot
B2RC66
resolver
uniprot
Q6FH69
resolver
uniprot_entry
EREG_HUMAN
resolver
uniprot_sec
B2RC66
resolver
uniprot_sec
Q6FH69
resolver
amino_acid_sequence
MTAGRRMEMLCAGRVPALLLCLGFHLLQAVLSTTVIPSCIPGESSDNCTALVQTEDNPRVAQVSITKCSSDMNGYCLHGQCIYLVDMSQNYCRCEVGYTGVRCEHFFLTVHQPLSKEYVALTVILIILFLITVVGSTYYFCRWYRNRKSKEPKKEYERVTSGDPELPQV
uniprot
proteins
function
FUNCTION: Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (PubMed:9419975). Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357). {ECO:0000269|PubMed:9419975, ECO:0000303|PubMed:24631357}.
uniprot
proteins
mass_dalton
19044
uniprot
proteins
pubmed
14572630
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
24631357
uniprot
proteins
pubmed
9337852
uniprot
proteins
pubmed
9419975
uniprot
proteins
sequence_length
169
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Epiregulin]: Secreted, extracellular space {ECO:0000269|PubMed:9337852}.; SUBCELLULAR LOCATION: [Proepiregulin]: Cell membrane {ECO:0000269|PubMed:9337852}; Single-pass type I membrane protein {ECO:0000269|PubMed:9337852}.
uniprot
proteins
transmembrane_region
TRANSMEM 120..140; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins