SRGN
entrez
5552
canonical
uniprot
P10124
canonical
ensembl
ENSG00000122862
resolver
ensp
ENSP00000242465
resolver
ensp
ENSP00000520834
resolver
enst
ENST00000242465
resolver
enst
ENST00000718456
resolver
genesymbol
SRGN
resolver
genesymbol_syn
PRG
resolver
genesymbol_syn
PRG1
resolver
hgnc
HGNC:9361
resolver
uniprot
B2R4L7
resolver
uniprot
Q5VW06
resolver
uniprot_entry
SRGN_HUMAN
resolver
uniprot_sec
B2R4L7
resolver
uniprot_sec
Q5VW06
resolver
amino_acid_sequence
MMQKLLKCSRLVLALALILVLESSVQGYPTRRARYQWVRCNPDSNSANCLEEKGPMFELLPGESNKIPRLRTDLFPKTRIQDLNRIFPLSEDYSGSGFGSGSGSGSGSGSGFLTEMEQDYQLVDESDAFHDNLRSLDRNLPSDSQDLGQHGLEEDFML
uniprot
proteins
function
FUNCTION: Plays a role in formation of mast cell secretory granules and mediates storage of various compounds in secretory vesicles. Required for storage of some proteases in both connective tissue and mucosal mast cells and for storage of granzyme B in T-lymphocytes. Plays a role in localizing neutrophil elastase in azurophil granules of neutrophils. Mediates processing of MMP2. Plays a role in cytotoxic cell granule-mediated apoptosis by forming a complex with granzyme B which is delivered to cells by perforin to induce apoptosis. Regulates the secretion of TNF and may also regulate protease secretion. Inhibits bone mineralization. {ECO:0000269|PubMed:11911826, ECO:0000269|PubMed:16420477, ECO:0000269|PubMed:16870619}.
uniprot
proteins
mass_dalton
17652
uniprot
proteins
post_translational_modification
PTM: O-glycosylated; contains chondroitin sulfate and heparan sulfate. {ECO:0000250}.
uniprot
proteins
protein_family
Serglycin family
uniprot
proteins
pubmed
11154222
uniprot
proteins
pubmed
11911826
uniprot
proteins
pubmed
12388539
uniprot
proteins
pubmed
1377686
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15136585
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16420477
uniprot
proteins
pubmed
16870619
uniprot
proteins
pubmed
2180935
uniprot
proteins
pubmed
2798108
uniprot
proteins
pubmed
2835370
uniprot
proteins
pubmed
3214420
uniprot
proteins
pubmed
3402609
uniprot
proteins
sequence_length
158
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic granule {ECO:0000269|PubMed:11154222}. Cytolytic granule {ECO:0000269|PubMed:11154222}. Secreted, extracellular space {ECO:0000269|PubMed:11154222, ECO:0000269|PubMed:16870619}. Golgi apparatus {ECO:0000269|PubMed:11154222, ECO:0000269|PubMed:15136585}. Note=Found in mast cell granules and in cytoplasmic granules of cytolytic T lymphocytes from where it is secreted upon cell activation (By similarity). Secreted constitutively by endothelial cells and macrophages (PubMed:11154222). Located to Golgi apparatus during neutrophil differentiation (PubMed:15136585). {ECO:0000250|UniProtKB:P13609, ECO:0000269|PubMed:11154222, ECO:0000269|PubMed:15136585}.
uniprot
proteins