Sorcs2
entrez
81840
canonical
uniprot
Q9EPR5
canonical
ensembl
ENSMUSG00000029093
resolver
ensp
ENSMUSP00000041828
resolver
ensp
ENSMUSP00000065292
resolver
ensp
ENSMUSP00000173866
resolver
enst
ENSMUST00000037370
resolver
enst
ENSMUST00000070720
resolver
genesymbol
Sorcs2
resolver
uniprot
B2RSI2
resolver
uniprot
B2RSI4
resolver
uniprot
F6ZSP2
resolver
uniprot
Q8BI61
resolver
uniprot
Q8BI74
resolver
uniprot_entry
F6ZSP2_MOUSE
resolver
uniprot_entry
Q8BI61_MOUSE
resolver
uniprot_entry
Q8BI74_MOUSE
resolver
uniprot_entry
SORC2_MOUSE
resolver
uniprot_sec
B2RSI2
resolver
uniprot_sec
B2RSI4
resolver
amino_acid_sequence
MAHRGPPSAPKRPGPTAPDRSFQALLPPCWPRSWPLLLLLLVLVAACGAMGRSPQPGRQGPGVQITRLLPAGRTESGDRKDPQARESEPSVPGLGPGSASGPSTDGAPAPGKGRRARAVPVAGAASASRAQVSLISTSFVLKGDATHNQAMVHWTGENSSVILILTKYYHADMGKVLESSLWRSSDFGTTYTKLTLQPGVTTVIDNFYICPANKRKIILVSSSLGDREQSLFLSTDEGATFQKYPVPFLVEMLLFHPKEEDKVLAYTKDSKLYVSSDLGKKWTLLQERVTKDHVFWAVSGVDDDPNLVHVEAQDLSGGYRYYTCLIYNCSAQPHIAPFSGPIDRGSLTVQDEYIFLKATSTNRTKYYVSYRRSDFVLMKLPKYALPKDLQIISTDEQQVFVAVQEWNQVDTYNLYQSDLRGVRYSLVLENVRSSRQAEENVVIDILEVRGVKGVFLANQKVDGKVTTVITYNKGRDWDYLRPPSTDMNGKPTNCQPPDCYLHLHLRWADNPYVSGTVHTKDTAPGLIMGAGNLGSQLVEYKEEMYITSDCGHTWRQVFEEEHHVLYLDHGGVIAAIKDTSIPLKILKFSVDEGHTWSTHNFTSTSVFVDGLLSEPGDETLVMTVFGHISFRSDWELVKVDFRPSFPRQCGEDDYSSWDLTDLQGDHCIMGQQRSYRKRKSTSWCVKGRSFTSALTSRVCKCRDSDFLCDYGFERSSSSESTANKCSANFWFNPLSPPEDCVLGQTYTSSLGYRKVVSNVCEGGVDLQQSPVQLQCPLQAPRGLQVSIRGEAVAVRPREDVLFVVRQEQGDVLTTKYQVDLGDGFKAMYVNLTLTGEPIRHHYESPGIYRVSVRAENMAGHDEAVLFVQVNSPLQALYLEVVPVIGVNQEVNLTAVLLPLNPNLTVFYWWIGHSLQPLLSLDNSVTTKFTDAGDVRVTVQAACGNSVLQDSRLVRVLDQFQVVPLRFSRELDTFNPNTPEWREDVGLVVTRLLSKETSIPEELLVTVVKPGLPTIADLYVLLPLPRPTRKRSLTSDKRLAAVQQALNSHRISFILRGGLRILVELRDTDTGPQRPGGSGGYWAVVVLFVIGLFAVGAFILYKFKRKRPGRTVYAQMHNEKEQEMTSPVSHSEDAQSTMQGNHSGVVLSINSREMHSYLVG
uniprot
proteins
function
FUNCTION: The heterodimer formed by NGFR and SORCS2 functions as receptor for the precursor forms of NGF (proNGF) and BDNF (proBDNF) (PubMed:22155786, PubMed:24908487, PubMed:27457814, PubMed:29909994). ProNGF and proBDNF binding both promote axon growth cone collapse (in vitro) (PubMed:24908487). Plays a role in the regulation of dendritic spine density in hippocampus neurons (PubMed:29909994). Required for normal neurite branching and extension in response to BDNF (PubMed:27457814, PubMed:29909994). Plays a role in BDNF-dependent hippocampal synaptic plasticity (PubMed:27457814, PubMed:29909994). Together with NGFR and NTRK2, is required both for BDNF-mediated synaptic long-term depression and long-term potentiation (PubMed:27457814). ProNGF binding promotes dissociation of TRIO from the heterodimer, which leads to inactivation of RAC1 and/or RAC2 and subsequent reorganization of the actin cytoskeleton (By similarity). Together with the retromer complex subunit VPS35, required for normal expression of GRIN2A at synapses and dendritic cell membranes (PubMed:28469074). Required for normal expression of the amino acid transporter SLC1A1 at the cell membrane, and thereby contributes to protect cells against oxidative stress (PubMed:30840898). {ECO:0000250|UniProtKB:Q96PQ0, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:24908487, ECO:0000269|PubMed:27457814, ECO:0000269|PubMed:28469074, ECO:0000269|PubMed:29909994, ECO:0000269|PubMed:30840898}.
uniprot
proteins
mass_dalton
128902
uniprot
proteins
mutagenesis
MUTAGEN 630; /note="F->N: Introduces an N-glycosylation site and disrupts interaction with NGF and BDNF."; /evidence="ECO:0000269|PubMed:30061605
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q96PQ0}.; PTM: Proteolytic cleavage removes a propeptide, giving rise to a 122 kDa chain that includes a cytoplasmic tail. Further cleavage gives rise to a 104 kDa chain that lacks the cytoplasmic tail, and a membrane-bound 18 kDa chain (PubMed:24908487). The 104 kDa chain remains bound to the 18 kDa chain (By similarity). {ECO:0000250|UniProtKB:Q96PQ0, ECO:0000269|PubMed:24908487}.
uniprot
proteins
protein_family
SORCS subfamily
uniprot
proteins
protein_family
VPS10-related sortilin family
uniprot
proteins
pubmed
11165493
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22155786
uniprot
proteins
pubmed
24908487
uniprot
proteins
pubmed
27457814
uniprot
proteins
pubmed
28346477
uniprot
proteins
pubmed
28469074
uniprot
proteins
pubmed
29909994
uniprot
proteins
pubmed
30061605
uniprot
proteins
pubmed
30840898
uniprot
proteins
sequence_length
1159
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:24908487, ECO:0000269|PubMed:27457814, ECO:0000269|PubMed:30840898, ECO:0000305|PubMed:30061605}; Single-pass type I membrane protein {ECO:0000305|PubMed:30061605}. Cell projection {ECO:0000269|PubMed:24908487}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:28469074, ECO:0000269|PubMed:30840898}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q96PQ0}. Early endosome membrane {ECO:0000269|PubMed:30840898}. Recycling endosome membrane {ECO:0000269|PubMed:30840898}. Synapse, synaptosome {ECO:0000269|PubMed:30840898}. Perikaryon {ECO:0000269|PubMed:28469074}. Cell projection, dendrite {ECO:0000269|PubMed:27457814}. Cell projection, dendritic spine {ECO:0000269|PubMed:29909994}. Synapse {ECO:0000269|PubMed:27457814}. Postsynaptic density membrane {ECO:0000269|PubMed:27457814}.
uniprot
proteins
transmembrane_region
TRANSMEM 1079..1099; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins