EDNRA
entrez
1909
canonical
uniprot
P25101
canonical
ensembl
ENSG00000151617
resolver
ensp
ENSP00000351359
resolver
ensp
ENSP00000498969
resolver
ensp
ENSP00000792647
resolver
genesymbol
EDNRA
resolver
genesymbol_syn
ETA
resolver
genesymbol_syn
ETRA
resolver
hgnc
HGNC:3179
resolver
uniprot
B2R723
resolver
uniprot
B4E2V6
resolver
uniprot
B7Z9G6
resolver
uniprot
D3DP03
resolver
uniprot
E7ER36
resolver
uniprot
O43441
resolver
uniprot
Q16432
resolver
uniprot
Q16433
resolver
uniprot
Q8TBH2
resolver
uniprot_entry
EDNRA_HUMAN
resolver
uniprot_sec
B2R723
resolver
uniprot_sec
B4E2V6
resolver
uniprot_sec
B7Z9G6
resolver
uniprot_sec
D3DP03
resolver
uniprot_sec
E7ER36
resolver
uniprot_sec
O43441
resolver
uniprot_sec
Q16432
resolver
uniprot_sec
Q16433
resolver
uniprot_sec
Q8TBH2
resolver
amino_acid_sequence
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN
uniprot
proteins
disease_involvement
DISEASE: Mandibulofacial dysostosis with alopecia (MFDA) [MIM:616367]: A form of mandibulofacial dysostosis, a disorder characterized by malar and mandibular hypoplasia, typically associated with abnormalities of the ears and eyelids. MFDA features include maxillary dysmorphism with dysplastic zygomatic arch, hypoplastic mandible, scalp alopecia, scant eyebrows and eyelashes, severe hypoplasia or aplasia of eyelids, small cupped dysplastic ears, conductive hearing loss, cleft palate, dental anomalies, micrognathia, and limited jaw mobility. {ECO:0000269|PubMed:25772936}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3.
uniprot
proteins
mass_dalton
48722
uniprot
proteins
protein_family
EDNRA sub-subfamily
uniprot
proteins
protein_family
Endothelin receptor subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11262386
uniprot
proteins
pubmed
1291713
uniprot
proteins
pubmed
1326535
uniprot
proteins
pubmed
1415318
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
1652463
uniprot
proteins
pubmed
1659806
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
1719979
uniprot
proteins
pubmed
25772936
uniprot
proteins
pubmed
8427579
uniprot
proteins
pubmed
8440682
uniprot
proteins
pubmed
8611157
uniprot
proteins
pubmed
9284755
uniprot
proteins
sequence_length
427
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 81..102; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 113..132; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 160..181; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 206..229; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 257..278; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 307..328; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 348..372; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins