PDE1B
entrez
5153
canonical
uniprot
Q01064
canonical
ensembl
ENSG00000123360
resolver
ensp
ENSP00000243052
resolver
ensp
ENSP00000442559
resolver
ensp
ENSP00000448519
resolver
enst
ENST00000538346
resolver
genesymbol
PDE1B
resolver
genesymbol_syn
PDES1B
resolver
hgnc
HGNC:8775
resolver
uniprot
B3KX78
resolver
uniprot
B4DK72
resolver
uniprot
F6Y3G2
resolver
uniprot
Q92825
resolver
uniprot
Q96KP3
resolver
uniprot_entry
B3KX78_HUMAN
resolver
uniprot_entry
B4DK72_HUMAN
resolver
uniprot_entry
F6Y3G2_HUMAN
resolver
uniprot_entry
PDE1B_HUMAN
resolver
uniprot_sec
Q92825
resolver
uniprot_sec
Q96KP3
resolver
activity_regulation
ACTIVITY REGULATION: Type I PDE are activated by the binding of calmodulin in the presence of Ca(2+). {ECO:0000269|PubMed:9419816}.
uniprot
proteins
amino_acid_sequence
MELSPRSPPEMLEESDCPSPLELKSAPSKKMWIKLRSLLRYMVKQLENGEINIEELKKNLEYTASLLEAVYIDETRQILDTEDELQELRSDAVPSEVRDWLASTFTQQARAKGRRAEEKPKFRSIVHAVQAGIFVERMFRRTYTSVGPTYSTAVLNCLKNLDLWCFDVFSLNQAADDHALRTIVFELLTRHNLISRFKIPTVFLMSFLDALETGYGKYKNPYHNQIHAADVTQTVHCFLLRTGMVHCLSEIELLAIIFAAAIHDYEHTGTTNSFHIQTKSECAIVYNDRSVLENHHISSVFRLMQDDEMNIFINLTKDEFVELRALVIEMVLATDMSCHFQQVKTMKTALQQLERIDKPKALSLLLHAADISHPTKQWLVHSRWTKALMEEFFRQGDKEAELGLPFSPLCDRTSTLVAQSQIGFIDFIVEPTFSVLTDVAEKSVQPLADEDSKSKNQPSFQWRQPSLDVEVGDPNPDVVSFRSTWVKRIQENKQKWKERAASGITNQMSIDELSPCEEEAPPSPAEDEHNQNGNLD
uniprot
proteins
ec_number
3.1.4.17
uniprot
proteins
function
FUNCTION: Cyclic nucleotide phosphodiesterase with a dual specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (PubMed:15260978, PubMed:8855339, PubMed:9419816). Has a preference for cGMP as a substrate (PubMed:9419816). {ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:8855339, ECO:0000269|PubMed:9419816}.
uniprot
proteins
mass_dalton
61380
uniprot
proteins
protein_family
Cyclic nucleotide phosphodiesterase family
uniprot
proteins
protein_family
PDE1 subfamily
uniprot
proteins
pubmed
11747989
uniprot
proteins
pubmed
1326532
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15260978
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8855339
uniprot
proteins
pubmed
9419816
uniprot
proteins
sequence_length
536
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:8855339}.
uniprot
proteins