DESI1
entrez
27351
canonical
uniprot
Q6ICB0
canonical
ensembl
ENSG00000100418
resolver
ensp
ENSP00000263256
resolver
enst
ENST00000263256
resolver
genesymbol
DESI1
resolver
genesymbol_syn
FAM152B
resolver
genesymbol_syn
PPPDE2
resolver
hgnc
HGNC:24577
resolver
uniprot_entry
DESI1_HUMAN
resolver
activity_regulation
ACTIVITY REGULATION: Palmostatin B inhibits its palmitoyl protein thioesterase activity. {ECO:0000269|PubMed:35427157}.
uniprot
proteins
amino_acid_sequence
MEPPNLYPVKLYVYDLSKGLARRLSPIMLGKQLEGIWHTSIVVHKDEFFFGSGGISSCPPGGTLLGPPDSVVDVGSTEVTEEIFLEYLSSLGESLFRGEAYNLFEHNCNTFSNEVAQFLTGRKIPSYITDLPSEVLSTPFGQALRPLLDSIQIQPPGGSSVGRPNGQS
uniprot
proteins
ec_number
3.1.2.22
uniprot
proteins
ec_number
3.4.-.-
uniprot
proteins
function
FUNCTION: Protease which deconjugates SUMO1, SUMO2 and SUMO3 from some substrate proteins. Has isopeptidase but not SUMO-processing activity (By similarity). Desumoylates ZBTB46 (By similarity). Collaborates with UBQLN4 in the export of ubiquitinated proteins from the nucleus to the cytoplasm (PubMed:29666234). Exhibits palmitoyl protein thioesterase (S-depalmitoylation) activity towards synthetic substrates 4-methylumbelliferyl-6-S-palmitoyl-beta-D-glucopyranoside and S-depalmitoylation probe 5 (DPP-5) (PubMed:35427157). {ECO:0000250|UniProtKB:Q9CQT7, ECO:0000269|PubMed:29666234, ECO:0000269|PubMed:35427157}.
uniprot
proteins
mass_dalton
18263
uniprot
proteins
protein_family
DeSI family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
29666234
uniprot
proteins
pubmed
35427157
uniprot
proteins
sequence_length
168
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:29666234}. Nucleus {ECO:0000269|PubMed:29666234}. Note=Shuttles between the nucleus and the cytoplasm; exported from the nucleus in a XPO1/CRM1-dependent manner via its nuclear export signal motifs. {ECO:0000269|PubMed:29666234}.
uniprot
proteins