NEK10
entrez
152110
canonical
uniprot
Q6ZWH5
canonical
ensembl
ENSG00000163491
resolver
ensp
ENSP00000295720
resolver
ensp
ENSP00000343847
resolver
ensp
ENSP00000373281
resolver
ensp
ENSP00000395849
resolver
ensp
ENSP00000509472
resolver
ensp
ENSP00000568365
resolver
ensp
ENSP00000606130
resolver
ensp
ENSP00000615467
resolver
enst
ENST00000691995
resolver
enst
ENST00000898306
resolver
genesymbol
NEK10
resolver
hgnc
HGNC:18592
resolver
uniprot
A0A650C2C8
resolver
uniprot
A0A8I5KTB8
resolver
uniprot
A8MWG1
resolver
uniprot
B9ZVR0
resolver
uniprot
Q45VJ4
resolver
uniprot
Q6ZR11
resolver
uniprot
Q7Z671
resolver
uniprot
Q86XB1
resolver
uniprot
Q8N774
resolver
uniprot
Q96MB3
resolver
uniprot_entry
A0A650C2C8_HUMAN
resolver
uniprot_entry
A0A8I5KTB8_HUMAN
resolver
uniprot_entry
NEK10_HUMAN
resolver
uniprot_entry
Q8N774_HUMAN
resolver
uniprot_sec
A8MWG1
resolver
uniprot_sec
B9ZVR0
resolver
uniprot_sec
Q45VJ4
resolver
uniprot_sec
Q6ZR11
resolver
uniprot_sec
Q7Z671
resolver
uniprot_sec
Q86XB1
resolver
uniprot_sec
Q96MB3
resolver
amino_acid_sequence
MPDQDKKVKTTEKSTDKQQEITIRDYSDLKRLRCLLNVQSSKQQLPAINFDSAQNSMTKSEPAIRAGGHRARGQWHESTEAVELENFSINYKNERNFSKHPQRKLFQEIFTALVKNRLISREWVNRAPSIHFLRVLICLRLLMRDPCYQEILHSLGGIENLAQYMEIVANEYLGYGEEQHTVDKLVNMTYIFQKLAAVKDQREWVTTSGAHKTLVNLLGARDTNVLLGSLLALASLAESQECREKISELNIVENLLMILHEYDLLSKRLTAELLRLLCAEPQVKEQVKLYEGIPVLLSLLHSDHLKLLWSIVWILVQVCEDPETSVEIRIWGGIKQLLHILQGDRNFVSDHSSIGSLSSANAAGRIQQLHLSEDLSPREIQENTFSLQAACCAALTELVLNDTNAHQVVQENGVYTIAKLILPNKQKNAAKSNLLQCYAFRALRFLFSMERNRPLFKRLFPTDLFEIFIDIGHYVRDISAYEELVSKLNLLVEDELKQIAENIESINQNKAPLKYIGNYAILDHLGSGAFGCVYKVRKHSGQNLLAMKEVNLHNPAFGKDKKDRDSSVRNIVSELTIIKEQLYHPNIVRYYKTFLENDRLYIVMELIEGAPLGEHFSSLKEKHHHFTEERLWKIFIQLCLALRYLHKEKRIVHRDLTPNNIMLGDKDKVTVTDFGLAKQKQENSKLTSVVGTILYSCPEVLKSEPYGEKADVWAVGCILYQMATLSPPFYSTNMLSLATKIVEAVYEPVPEGIYSEKVTDTISRCLTPDAEARPDIVEVSSMISDVMMKYLDNLSTSQLSLEKKLERERRRTQRYFMEANRNTVTCHHELAVLSHETFEKASLSSSSSGAASLKSELSESADLPPEGFQASYGKDEDRACDEILSDDNFNLENAEKDTYSEVDDELDISDNSSSSSSSPLKESTFNILKRSFSASGGERQSQTRDFTGGTGSRPRPALLPLDLLLKVPPHMLRAHIKEIEAELVTGWQSHSLPAVILRNLKDHGPQMGTFLWQASAGIAVSQRKVRQISDPIQQILIQLHKIIYITQLPPALHHNLKRRVIERFKKSLFSQQSNPCNLKSEIKKLSQGSPEPIEPNFFTADYHLLHRSSGGNSLSPNDPTGLPTSIELEEGITYEQMQTVIEEVLEESGYYNFTSNRYHSYPWGTKNHPTKR
uniprot
proteins
disease_involvement
DISEASE: Ciliary dyskinesia, primary, 44 (CILD44) [MIM:618781]: A form of primary ciliary dyskinesia, a disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. CILD44 inheritance is autosomal recessive. {ECO:0000269|PubMed:31959991}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Plays a role in the cellular response to UV irradiation. Mediates G2/M cell cycle arrest, MEK autoactivation and ERK1/2-signaling pathway activation in response to UV irradiation. In ciliated cells of airways, it is involved in the regulation of mucociliary transport (PubMed:31959991). {ECO:0000269|PubMed:20956560, ECO:0000269|PubMed:31959991}.
uniprot
proteins
mass_dalton
133259
uniprot
proteins
mutagenesis
MUTAGEN 548; /note="K->R: Catalytically inactive. Impaired mucociliary transport."; /evidence="ECO:0000269|PubMed:20956560, ECO:0000269|PubMed:31959991"; MUTAGEN 684; /note="S->D: Increased mucociliary transport."; /evidence="ECO:0000269|PubMed:31959991
uniprot
proteins
protein_family
NEK Ser/Thr protein kinase family
uniprot
proteins
protein_family
NIMA subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
20956560
uniprot
proteins
pubmed
31959991
uniprot
proteins
sequence_length
1172
uniprot
proteins