Psmc2
entrez
25581
canonical
uniprot
Q63347
canonical
ensembl
ENSRNOG00000012026
resolver
ensp
ENSRNOP00000016450
resolver
enst
ENSRNOT00000016450
resolver
genesymbol
Psmc2
resolver
genesymbol_syn
Mss1
resolver
uniprot
G3V7L6
resolver
uniprot
Q62690
resolver
uniprot
Q6P7R9
resolver
uniprot_entry
G3V7L6_RAT
resolver
uniprot_entry
PRS7_RAT
resolver
uniprot_sec
Q62690
resolver
uniprot_sec
Q6P7R9
resolver
amino_acid_sequence
MPDYLGADQRKTKEDEKDDKPIRALDEGDIALLKTYGQSTYSRQIKQVEDDIQQLLKKINELTGIKESDTGLAPPALWDLAADKQTLQSEQPLQVARCTKIINADSEDPKYIINVKQFAKFVVDLSDQVAPTDIEEGMRVGVDRNKYQIHIPLPPKIDPTVTMMQVEEKPDVTYSDVGGCKEQIEKLREVVETPLLHPERFVNLGIEPPKGVLLFGPPGTGKTLCARAVANRTDACFIPVIGSELVQKYVGEGARMVRELFEMARTKKACLIFFDEIDAIGGARFDDGAGGDNEVQRTMLELINQLDGFDPRGNIKVLMATNRPDTLDPALMRPGRLDRKIEFSLPDLEGRTHIFKIHARSMSVERDIRFELLARLCPNSTGAEIRSVCTEAGMFAIRARRKIATEKDFLEAVNKVIKSYAKFSATPRYMTYN
uniprot
proteins
function
FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC2 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000250|UniProtKB:P35998}.
uniprot
proteins
mass_dalton
48575
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated by RNF181. {ECO:0000250|UniProtKB:P35998}.; PTM: Phosphorylated. Dephosphorylated by UBLCP1 which impairs PSMC2 ATPase activity and disrupts 26S proteasome assembly. {ECO:0000250|UniProtKB:P35998}.
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8607789
uniprot
proteins
pubmed
9533861
uniprot
proteins
sequence_length
433
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P35998}. Note=Colocalizes with TRIM5 in cytoplasmic bodies. {ECO:0000250|UniProtKB:P35998}.
uniprot
proteins