TBCB
entrez
1155
canonical
uniprot
Q99426
canonical
ensembl
ENSG00000105254
resolver
ensp
ENSP00000221855
resolver
ensp
ENSP00000467487
resolver
genesymbol
TBCB
resolver
genesymbol_syn
CG22
resolver
genesymbol_syn
CKAP1
resolver
hgnc
HGNC:1989
resolver
uniprot
O00111
resolver
uniprot
O00674
resolver
uniprot
O14728
resolver
uniprot
Q6FGY5
resolver
uniprot_entry
TBCB_HUMAN
resolver
uniprot_sec
O00111
resolver
uniprot_sec
O00674
resolver
uniprot_sec
O14728
resolver
uniprot_sec
Q6FGY5
resolver
amino_acid_sequence
MEVTGVSAPTVTVFISSSLNTFRSEKRYSRSLTIAEFKCKLELLVGSPASCMELELYGVDDKFYSKLDQEDALLGSYPVDDGCRIHVIDHSGARLGEYEDVSRVEKYTISQEAYDQRQDTVRSFLKRSKLGRYNEEERAQQEAEAAQRLAEEKAQASSIPVGSRCEVRAAGQSPRRGTVMYVGLTDFKPGYWIGVRYDEPLGKNDGSVNGKRYFECQAKYGAFVKPAVVTVGDFPEEDYGLDEI
uniprot
proteins
disease_involvement
DISEASE: Neurodevelopmental disorder with behavioral abnormalities and childhood-onset spastic paraplegia (NEDBSPG) [MIM:621382]: An autosomal recessive disorder characterized by global developmental delay, behavioral abnormalities, most commonly autism spectrum disorder, and late-childhood onset of slowly progressive spastic paraplegia. {ECO:0000269|PubMed:40856104}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (PubMed:9265649). Involved in regulation of tubulin heterodimer dissociation. May function as a negative regulator of axonal growth (By similarity). {ECO:0000250|UniProtKB:Q9D1E6, ECO:0000269|PubMed:9265649}.
uniprot
proteins
mass_dalton
27326
uniprot
proteins
mutagenesis
MUTAGEN 65; /note="S->A: Reduced phosphorylation by PAK1. Reduced microtubule polymerization and loss of phosphorylation by PAK1; when associated with A-128."; /evidence="ECO:0000269|PubMed:15831477"; MUTAGEN 128; /note="S->A: Reduced phosphorylation by PAK1. Reduced microtubule polymerization and loss of phosphorylation by PAK1; when associated with A-65."; /evidence="ECO:0000269|PubMed:15831477
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by PAK1 is required for normal function. {ECO:0000269|PubMed:15831477}.; PTM: Ubiquitinated in the presence of GAN which targets it for degradation by the proteasome. {ECO:0000269|PubMed:16303566}.; PTM: (Microbial infection) Glycosylated residues by S.typhimurium protein Ssek1: arginine GlcNAcylation promotes microtubule stability. {ECO:0000269|PubMed:32366039}.
uniprot
proteins
protein_family
TBCB family
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15831477
uniprot
proteins
pubmed
16303566
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22777741
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
32366039
uniprot
proteins
pubmed
40856104
uniprot
proteins
pubmed
8978778
uniprot
proteins
pubmed
9265649
uniprot
proteins
sequence_length
244
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15831477, ECO:0000269|PubMed:22777741}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15831477}. Note=Colocalizes with microtubules. In differentiated neurons, located in the cytoplasm. In differentiating neurons, accumulates at the growth cone. {ECO:0000269|PubMed:15831477}.
uniprot
proteins