DECR2
entrez
26063
canonical
uniprot
Q9NUI1
canonical
ensembl
ENSG00000242612
resolver
ensembl
ENSG00000274296
resolver
ensp
ENSP00000219481
resolver
genesymbol
DECR2
resolver
genesymbol_syn
PDCR
resolver
genesymbol_syn
SDR17C1
resolver
hgnc
HGNC:2754
resolver
uniprot
Q6ZRS7
resolver
uniprot
Q96ET0
resolver
uniprot_entry
DECR2_HUMAN
resolver
uniprot_sec
Q6ZRS7
resolver
uniprot_sec
Q96ET0
resolver
amino_acid_sequence
MAQPPPDVEGDDCLPAYRHLFCPDLLRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAGATGRRCLPLSMDVRAPPAVMAAVDQALKEFGRIDILINCAAGNFLCPAGALSFNAFKTVMDIDTSGTFNVSRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVEWGPQNIRVNSLAPGPISGTEGLRRLGGPQASLSTKVTASPLQRLGNKTEIAHSVLYLASPLASYVTGAVLVADGGAWLTFPNGVKGLPDFASFSAKL
uniprot
proteins
ec_number
1.3.1.124
uniprot
proteins
function
FUNCTION: Auxiliary enzyme of beta-oxidation. Participates in the degradation of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions in peroxisome. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3-enoyl-CoA. Has activity towards short and medium chain 2,4-dienoyl-CoAs, but also towards 2,4,7,10,13,16,19-docosaheptaenoyl-CoA, suggesting that it does not constitute a rate limiting step in the peroxisomal degradation of docosahexaenoic acid. {ECO:0000269|PubMed:11514237, ECO:0000269|PubMed:22745130}.
uniprot
proteins
mass_dalton
30778
uniprot
proteins
mutagenesis
MUTAGEN 86; /note="D->A: Reduces enzyme activity by 98%."; /evidence="ECO:0000269|PubMed:22745130"; MUTAGEN 137; /note="D->A: Reduces enzyme activity by 97%."; /evidence="ECO:0000269|PubMed:22745130"; MUTAGEN 186; /note="D->A: Reduces enzyme activity by about 95%."; /evidence="ECO:0000269|PubMed:22745130"; MUTAGEN 268; /note="D->A: Reduces enzyme activity by 97%."; /evidence="ECO:0000269|PubMed:22745130
uniprot
proteins
protein_family
2
uniprot
proteins
protein_family
4-dienoyl-CoA reductase subfamily
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
11157797
uniprot
proteins
pubmed
11514237
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
22745130
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
292
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome {ECO:0000250|UniProtKB:Q9Z2M4}.
uniprot
proteins