TRPC7
entrez
57113
canonical
uniprot
Q9HCX4
canonical
ensembl
ENSG00000069018
resolver
ensp
ENSP00000330322
resolver
ensp
ENSP00000367720
resolver
ensp
ENSP00000424854
resolver
ensp
ENSP00000426070
resolver
enst
ENST00000502753
resolver
genesymbol
TRPC7
resolver
genesymbol_syn
TRP7
resolver
hgnc
HGNC:20754
resolver
uniprot
A0ACM8Q2L7
resolver
uniprot
A1A4Z4
resolver
uniprot
F5H5U9
resolver
uniprot
H0Y9S0
resolver
uniprot
Q70T25
resolver
uniprot
Q70T26
resolver
uniprot
Q8IWP7
resolver
uniprot_entry
A0ACM8Q2L7_HUMAN
resolver
uniprot_entry
Q70T25_HUMAN
resolver
uniprot_entry
TRPC7_HUMAN
resolver
uniprot_sec
A1A4Z4
resolver
uniprot_sec
F5H5U9
resolver
uniprot_sec
H0Y9S0
resolver
uniprot_sec
Q70T26
resolver
uniprot_sec
Q8IWP7
resolver
amino_acid_sequence
MLRNSTFKNMQRRHTTLREKGRRQAIRGPAYMFNEKGTSLTPEEERFLDSAEYGNIPVVRKMLEESKTLNFNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARVGDALLLAISKGYVRIVEAILNHPAFAQGQRLTLSPLEQELRDDDFYAYDEDGTRFSHDITPIILAAHCQEYEIVHILLLKGARIERPHDYFCKCNECTEKQRKDSFSHSRSRMNAYKGLASAAYLSLSSEDPVLTALELSNELARLANIETEFKNDYRKLSMQCKDFVVGVLDLCRDTEEVEAILNGDVNFQVWSDHHRPSLSRIKLAIKYEVKKFVAHPNCQQQLLTMWYENLSGLRQQSIAVKFLAVFGVSIGLPFLAIAYWIAPCSKLGRTLRSPFMKFVAHAVSFTIFLGLLVVNASDRFEGVKTLPNETFTDYPKQIFRVKTTQFSWTEMLIMKWVLGMIWSECKEIWEEGPREYVLHLWNLLDFGMLSIFVASFTARFMAFLKATEAQLYVDQHVQDDTLHNVSLPPEVAYFTYARDKWWPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYRGAKYNPAFTTVEESFKTLFWSIFGLSEVISVVLKYDHKFIENIGYVLYGVYNVTMVVVLLNMLIAMINNSYQEIEEDADVEWKFARAKLWLSYFDEGRTLPAPFNLVPSPKSFYYLIMRIKMCLIKLCKSKAKSCENDLEMGMLNSKFKKTRYQAGMRNSENLTANNTLSKPTRYQKIMKRLIKRYVLKAQVDRENDEVNEGELKEIKQDISSLRYELLEEKSQATGELADLIQQLSEKFGKNLNKDHLRVNKGKDI
uniprot
proteins
function
FUNCTION: Non-selective, calcium-permeable cation channel. Also transports maganese. Contributes to both spontaneous and receptor stimulation-induced cationic currents. Receptor stimulation, including that of G(q)-coupled or receptor tyrosine kinase pathways, triggers phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositides, producing diacylglycerol (DAG) that activates TRPC7. May also be activated by depletion of intracellular calcium stores. Mediates depolarization of intrinsically photosensitive retinal ganglion cells (ipRGCs) in response to light-induced melanopsin (OPN4)-mediated phototransduction via G(q)-PLC signaling, likely by forming heteromeric TRPC6-TRPC7 channels. {ECO:0000250|UniProtKB:Q9WVC5}.
uniprot
proteins
mass_dalton
99562
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by PRKG1 at Thr-15 negatively regulates TRPC7 activity. {ECO:0000269|PubMed:21402151}.
uniprot
proteins
protein_family
STrpC subfamily
uniprot
proteins
protein_family
TRPC7 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15757897
uniprot
proteins
pubmed
17850865
uniprot
proteins
pubmed
21402151
uniprot
proteins
sequence_length
862
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21402151}; Multi-pass membrane protein {ECO:0000269|PubMed:21402151}. Nucleus envelope {ECO:0000269|PubMed:21402151}.
uniprot
proteins
transmembrane_region
TRANSMEM 352..372; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 384..404; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 466..486; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 538..558; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 582..602; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 652..672; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins