PTPN22
entrez
26191
canonical
uniprot
Q9Y2R2
canonical
ensembl
ENSG00000134242
resolver
ensp
ENSP00000352833
resolver
ensp
ENSP00000435176
resolver
ensp
ENSP00000439372
resolver
ensp
ENSP00000580105
resolver
ensp
ENSP00000580108
resolver
ensp
ENSP00000580109
resolver
enst
ENST00000538253
resolver
genesymbol
PTPN22
resolver
genesymbol_syn
PTPN8
resolver
hgnc
HGNC:9652
resolver
uniprot
A0N0K6
resolver
uniprot
B1ALC8
resolver
uniprot
B4DZW8
resolver
uniprot
D4NZ71
resolver
uniprot
E9PLD8
resolver
uniprot
E9PPI1
resolver
uniprot
F5H2S8
resolver
uniprot
G3K0T4
resolver
uniprot
O95063
resolver
uniprot
O95064
resolver
uniprot
Q6IPX8
resolver
uniprot
Q8WVM1
resolver
uniprot_entry
B4DZW8_HUMAN
resolver
uniprot_entry
F5H2S8_HUMAN
resolver
uniprot_entry
G3K0T4_HUMAN
resolver
uniprot_entry
PTN22_HUMAN
resolver
uniprot_sec
A0N0K6
resolver
uniprot_sec
B1ALC8
resolver
uniprot_sec
D4NZ71
resolver
uniprot_sec
E9PLD8
resolver
uniprot_sec
E9PPI1
resolver
uniprot_sec
O95063
resolver
uniprot_sec
O95064
resolver
uniprot_sec
Q6IPX8
resolver
uniprot_sec
Q8WVM1
resolver
activity_regulation
ACTIVITY REGULATION: Down-regulated by phosphorylation.
uniprot
proteins
amino_acid_sequence
MDQREILQKFLDEAQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDVIRDKHSGTESQAKHCIPEKNHTLQADSYSPNLPKSTTKAAKMMNQQRTKMEIKESSSFDFRTSEISAKEELVLHPAKSSTSFDFLELNYSFDKNADTTMKWQTKAFPIVGEPLQKHQSLDLGSLLFEGCSNSKPVNAAGRYFNSKVPITRTKSTPFELIQQRETKEVDSKENFSYLESQPHDSCFVEMQAQKVMHVSSAELNYSLPYDSKHQIRNASNVKHHDSSALGVYSYIPLVENPYFSSWPPSGTSSKMSLDLPEKQDGTVFPSSLLPTSSTSLFSYYNSHDSLSLNSPTNISSLLNQESAVLATAPRIDDEIPPPLPVRTPESFIVVEEAGEFSPNVPKSLSSAVKVKIGTSLEWGGTSEPKKFDDSVILRPSKSVKLRSPKSELHQDRSSPPPPLPERTLESFFLADEDCMQAQSIETYSTSYPDTMENSTSSKQTLKTPGKSFTRSKSLKILRNMKKSICNSCPPNKPAESVQSNNSSSFLNFGFANRFSKPKGPRNPPPTWNI
uniprot
proteins
disease_involvement
DISEASE: Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269|PubMed:15273934}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; DISEASE: Type 1 diabetes mellitus (T1D) [MIM:222100]: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269|PubMed:15004560}. Note=Disease susceptibility may be associated with variants affecting the gene represented in this entry.; DISEASE: Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. {ECO:0000269|PubMed:15208781}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; DISEASE: Vitiligo (VTLG) [MIM:193200]: A pigmentary disorder of the skin and mucous membranes. It is characterized by circumscribed depigmented macules and patches, commonly on extensor aspects of extremities, on the face or neck and in skin folds. Vitiligo is a progressive disorder in which some or all of the melanocytes in the affected skin are selectively destroyed. It is a multifactorial disorder with a complex etiology probably including autoimmune mechanisms, and is associated with an elevated risk of other autoimmune diseases. {ECO:0000269|PubMed:16015369}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Acts as a negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules (PubMed:16461343, PubMed:18056643). Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue (PubMed:21719704). Dephosphorylates ZAP70 at its activating 'Tyr-493' residue (PubMed:16461343). Dephosphorylates the immune system activator SKAP2 (PubMed:21719704). Positively regulates toll-like receptor (TLR)-induced type 1 interferon production (PubMed:23871208). Promotes host antiviral responses mediated by type 1 interferon (By similarity). Regulates NOD2-induced pro-inflammatory cytokine secretion and autophagy (PubMed:23991106). Acts as an activator of NLRP3 inflammasome assembly by mediating dephosphorylation of 'Tyr-861' of NLRP3 (PubMed:27043286). Dephosphorylates phospho-anandamide (p-AEA), an endocannabinoid to anandamide (also called N-arachidonoylethanolamide) (By similarity). {ECO:0000250|UniProtKB:P29352, ECO:0000269|PubMed:16461343, ECO:0000269|PubMed:18056643, ECO:0000269|PubMed:19167335, ECO:0000269|PubMed:21719704, ECO:0000269|PubMed:23871208, ECO:0000269|PubMed:23991106, ECO:0000269|PubMed:27043286}.
uniprot
proteins
mass_dalton
91705
uniprot
proteins
mutagenesis
MUTAGEN 35; /note="S->E: Loss of phosphorylation by PKC/PRKCD."; /evidence="ECO:0000269|PubMed:18056643"; MUTAGEN 36; /note="T->E: No effect on phosphorylation by PKC/PRKCD."; /evidence="ECO:0000269|PubMed:18056643"; MUTAGEN 129; /note="C->S: Decreases activity 2 fold."; /evidence="ECO:0000269|PubMed:19371084"; MUTAGEN 231; /note="C->S: Decreases activity 7 fold."; /evidence="ECO:0000269|PubMed:19371084
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Ser-35 by PKC/PRKCD abrogates its ability to dephosphorylate and inactivate the SRC family kinases. {ECO:0000269|PubMed:18056643}.
uniprot
proteins
protein_family
Non-receptor class 4 subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
10068674
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15004560
uniprot
proteins
pubmed
15208781
uniprot
proteins
pubmed
15273934
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15531553
uniprot
proteins
pubmed
15719322
uniprot
proteins
pubmed
16015369
uniprot
proteins
pubmed
16461343
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17729039
uniprot
proteins
pubmed
18056643
uniprot
proteins
pubmed
18981062
uniprot
proteins
pubmed
19167335
uniprot
proteins
pubmed
19265110
uniprot
proteins
pubmed
19371084
uniprot
proteins
pubmed
21044313
uniprot
proteins
pubmed
21287672
uniprot
proteins
pubmed
21719704
uniprot
proteins
pubmed
22427951
uniprot
proteins
pubmed
22952725
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23871208
uniprot
proteins
pubmed
23991106
uniprot
proteins
pubmed
27043286
uniprot
proteins
sequence_length
807
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P29352}.
uniprot
proteins