TOB1
entrez
10140
canonical
uniprot
P50616
canonical
ensembl
ENSG00000141232
resolver
ensp
ENSP00000268957
resolver
ensp
ENSP00000427695
resolver
ensp
ENSP00000521251
resolver
ensp
ENSP00000521252
resolver
ensp
ENSP00000521253
resolver
ensp
ENSP00000521254
resolver
ensp
ENSP00000602486
resolver
ensp
ENSP00000617358
resolver
enst
ENST00000268957
resolver
enst
ENST00000499247
resolver
enst
ENST00000851192
resolver
enst
ENST00000851193
resolver
enst
ENST00000851194
resolver
enst
ENST00000851195
resolver
enst
ENST00000932427
resolver
enst
ENST00000947299
resolver
genesymbol
TOB1
resolver
genesymbol_syn
TOB
resolver
genesymbol_syn
TROB1
resolver
hgnc
HGNC:11979
resolver
uniprot
B2R9T0
resolver
uniprot
D3DTY3
resolver
uniprot
Q4KMQ0
resolver
uniprot_entry
TOB1_HUMAN
resolver
uniprot_sec
B2R9T0
resolver
uniprot_sec
D3DTY3
resolver
uniprot_sec
Q4KMQ0
resolver
amino_acid_sequence
MQLEIQVALNFIISYLYNKLPRRRVNIFGEELERLLKKKYEGHWYPEKPYKGSGFRCIHIGEKVDPVIEQASKESGLDIDDVRGNLPQDLSVWIDPFEVSYQIGEKGPVKVLYVDDNNENGCELDKEIKNSFNPEAQVFMPISDPASSVSSSPSPPFGHSAAVSPTFMPRSTQPLTFTTATFAATKFGSTKMKNSGRSNKVARTSPINLGLNVNDLLKQKAISSSMHSLYGLGLGSQQQPQQQQQPAQPPPPPPPPQQQQQQKTSALSPNAKEFIFPNMQGQGSSTNGMFPGDSPLNLSPLQYSNAFDVFAAYGGLNEKSFVDGLNFSLNNMQYSNQQFQPVMAN
uniprot
proteins
function
FUNCTION: Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex (PubMed:23236473, PubMed:8632892). Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay (PubMed:21336257). {ECO:0000269|PubMed:21336257, ECO:0000269|PubMed:23236473, ECO:0000269|PubMed:8632892}.
uniprot
proteins
mass_dalton
38155
uniprot
proteins
mutagenesis
MUTAGEN 45; /note="Y->A: Impairs interaction with CNOT7 and CNOT8."; /evidence="ECO:0000269|PubMed:23236473"; MUTAGEN 55; /note="F->A: Impairs interaction with CNOT7 and CNOT8."; /evidence="ECO:0000269|PubMed:23236473"; MUTAGEN 65; /note="D->A: Impairs interaction with CNOT7 and CNOT8."; /evidence="ECO:0000269|PubMed:23236473"; MUTAGEN 93; /note="W->A: Impairs interaction with CNOT7 and CNOT8."; /evidence="ECO:0000269|PubMed:23236473"; MUTAGEN 95; /note="D->A: Impairs interaction with CNOT7 and CNOT8."; /evidence="ECO:0000269|PubMed:23236473
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser and Thr residues.
uniprot
proteins
protein_family
BTG family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19276069
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21336257
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23236473
uniprot
proteins
pubmed
8632892
uniprot
proteins
sequence_length
345
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Only a small fraction localizes to the cytoplasm except in late S-phase where more than half of proteins become cytoplasmic. {ECO:0000250}.
uniprot
proteins