Ftsj1
entrez
54632
canonical
uniprot
Q8CBC7
canonical
ensembl
ENSMUSG00000031171
resolver
ensp
ENSMUSP00000033513
resolver
ensp
ENSMUSP00000111258
resolver
genesymbol
Ftsj1
resolver
uniprot
A2ALH2
resolver
uniprot
Q8JZY1
resolver
uniprot
Q91XA6
resolver
uniprot_entry
TRM7_MOUSE
resolver
uniprot_sec
A2ALH2
resolver
uniprot_sec
Q8JZY1
resolver
uniprot_sec
Q91XA6
resolver
amino_acid_sequence
MGRTSKDKRDVYYRLAKENGWRARSAFKLLQLDEEFQLFKGVKRAVDLCAAPGSWSQVLSQKVGGQGSGQVVAVDLQAMAPLPGVIQIQGDITQLSTAKEIIQHFEGCPADLVVCDGAPDVTGLHDVDEYMQAQLLLAALNIATHVLKLGGCFVAKIFRGRDVTLLYSQLRIFFSSVLCAKPKSSRNSSIEAFAVCQGYDPPEGFIPDLTRPLLNHSYDTDFNQLDGPTRVIVPFVACGDLSAYDSDRTYSLDLDGGSEYKYTPPTQPPIAPPYQEACRLKKNGQLAKELLPQECSINSVDKLPQPLAIHTLLDPKVEDNEIHC
uniprot
proteins
ec_number
2.1.1.205
uniprot
proteins
function
FUNCTION: Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs (PubMed:33771871). Requisite for faithful cytoplasmic translation (PubMed:33771871). Requires THADA for methylation of the cytidine at position 32 of the anticodon loop of substrate tRNAs (By similarity). Requires WDR6 for methylation of the nucleotide at position 34 of the anticodon loop of substrate tRNAs (By similarity). Promotes translation efficiency of the UUU codon (PubMed:33771871). Plays a role in neurogenesis (PubMed:33771871, PubMed:36101392). Required for expression of genes involved in neurogenesis and mitochondrial translation and energy generation (PubMed:30557699, PubMed:33771871, PubMed:36101392). Requisite for RNA-mediated gene silencing (By similarity). May modify position 32 in tRNA(Arg(ACG)), tRNA(Gln(CUG)), tRNA(Leu(UAA)), tRNA(Leu(UAG)), tRNA(Leu(AAG)), tRNA(Leu(CAG)), tRNA(Phe(GAA)), tRNA(Trp(CCA)) and tRNA(Val(AAC)), and position 34 in tRNA(Phe(GAA)), tRNA(Leu(CAA)), tRNA(Leu(UAA)), tRNA(Sec(UCA)), and tRNA(Trp(CCA)) (PubMed:33771871). {ECO:0000250|UniProtKB:Q9UET6, ECO:0000269|PubMed:30557699, ECO:0000269|PubMed:33771871, ECO:0000269|PubMed:36101392}.
uniprot
proteins
mass_dalton
35586
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
RNA methyltransferase RlmE family
uniprot
proteins
protein_family
TRM7 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30557699
uniprot
proteins
pubmed
33771871
uniprot
proteins
pubmed
36101392
uniprot
proteins
sequence_length
324
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UET6}. Nucleus {ECO:0000250|UniProtKB:Q9UET6}. Note=Predominantly cytoplasmic. {ECO:0000250|UniProtKB:Q9UET6}.
uniprot
proteins