ANKRD9
entrez
122416
canonical
uniprot
Q96BM1
canonical
ensembl
ENSG00000156381
resolver
ensp
ENSP00000286918
resolver
ensp
ENSP00000453650
resolver
ensp
ENSP00000454100
resolver
ensp
ENSP00000549364
resolver
ensp
ENSP00000549365
resolver
ensp
ENSP00000549366
resolver
ensp
ENSP00000549367
resolver
ensp
ENSP00000549368
resolver
ensp
ENSP00000549369
resolver
ensp
ENSP00000549370
resolver
ensp
ENSP00000549371
resolver
ensp
ENSP00000610767
resolver
ensp
ENSP00000610768
resolver
ensp
ENSP00000625371
resolver
ensp
ENSP00000625372
resolver
ensp
ENSP00000625373
resolver
ensp
ENSP00000625374
resolver
ensp
ENSP00000625375
resolver
ensp
ENSP00000625376
resolver
ensp
ENSP00000625377
resolver
ensp
ENSP00000625378
resolver
ensp
ENSP00000625379
resolver
ensp
ENSP00000625380
resolver
ensp
ENSP00000625381
resolver
enst
ENST00000286918
resolver
enst
ENST00000559651
resolver
enst
ENST00000560748
resolver
enst
ENST00000879305
resolver
enst
ENST00000879306
resolver
enst
ENST00000879307
resolver
enst
ENST00000879308
resolver
enst
ENST00000879309
resolver
enst
ENST00000879310
resolver
enst
ENST00000879311
resolver
enst
ENST00000879312
resolver
enst
ENST00000940708
resolver
enst
ENST00000940709
resolver
enst
ENST00000955312
resolver
enst
ENST00000955313
resolver
enst
ENST00000955314
resolver
enst
ENST00000955315
resolver
enst
ENST00000955316
resolver
enst
ENST00000955317
resolver
enst
ENST00000955318
resolver
enst
ENST00000955319
resolver
enst
ENST00000955320
resolver
enst
ENST00000955321
resolver
enst
ENST00000955322
resolver
genesymbol
ANKRD9
resolver
hgnc
HGNC:20096
resolver
uniprot
A8K753
resolver
uniprot_entry
ANKR9_HUMAN
resolver
uniprot_sec
A8K753
resolver
amino_acid_sequence
MPWDARRPGGGADGGPEASGAARSRAQKQCRKSSFAFYQAVRDLLPVWLLEDMRASEAFHWDERGRAAAYSPSEALLYALVHDHQAYAHYLLATFPRRALAPPSAGFRCCAAPGPHVALAVRYNRVGILRRILRTLRDFPAEERARVLDRRGCSRVEGGGTSLHVACELARPECLFLLLGHGASPGLRDGGGLTPLELLLRQLGRDAGATPSAAGAPASAPGEPRQRRLLLLDLLALYTPVGAAGSARQELLGDRPRWQRLLGEDKFQWLAGLAPPSLFARAMQVLVTAISPGRFPEALDELPLPPFLQPLDLTGKG
uniprot
proteins
function
FUNCTION: Substrate receptor subunit of a cullin-RING superfamily E3 ligase complex (CUL5-based E3 ubiquitin ligase complex) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:30293565). Depending of the metabolic state of the cell, promotes the proteasomal degradation of IMPDH2, the rate-limiting enzyme in GTP biosynthesis or protects IMPDH2 by stabilizing IMPDH2 filaments assembly (PubMed:30293565, PubMed:31337707). Implicated in different cellular processes, like copper homeostasis and cell proliferation (PubMed:24522796, PubMed:30293565). {ECO:0000269|PubMed:24522796, ECO:0000269|PubMed:30293565, ECO:0000269|PubMed:31337707}.
uniprot
proteins
mass_dalton
34295
uniprot
proteins
mutagenesis
MUTAGEN 109; /note="C->S: Inhibits the vesicle-to-rods transition under nutrient-limiting conditions. Inhibits the vesicle-to-rods transition under nutrient-limiting conditions; when associated with C-110. Prevents the colocalization of ANKRD9 with IMPDH2 filaments. Increases the abundance of IMPDH2. Increases the abundance of IMPDH2; when associated with C-110."; /evidence="ECO:0000269|PubMed:31337707"; MUTAGEN 110; /note="C->S: Inhibits the vesicle-to-rods transition under nutrient-limiting conditions. Inhibits the vesicle-to-rods transition under nutrient-limiting conditions; when associated with C-109. Does not affect the abundance of IMPDH2."; /evidence="ECO:0000269|PubMed:31337707"; MUTAGEN 125; /note="R->A: Loss the vesicle-like pattern and becomes diffuse in the cytosol."; /evidence="ECO:0000269|PubMed:31337707
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000305|PubMed:30293565}.
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24522796
uniprot
proteins
pubmed
30293565
uniprot
proteins
pubmed
31337707
uniprot
proteins
sequence_length
317
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000269|PubMed:31337707}. Cytoplasm, cytosol {ECO:0000269|PubMed:30293565, ECO:0000269|PubMed:31337707}. Note=Detected in long filamentous cytosolic structures where it colocalizes with IMPDH2 (PubMed:31337707). Under basal conditions ANKRD9 is mainly in vesicle-like structures, upon nutrient limitation (guanine nucleotides deficiency) ANKRD9 loses its vesicular pattern and assembles with IMPDH2 into rodlike filaments (PubMed:31337707). {ECO:0000269|PubMed:31337707}.
uniprot
proteins