PPIL2
entrez
23759
canonical
uniprot
Q13356
canonical
ensembl
ENSG00000100023
resolver
ensp
ENSP00000334553
resolver
ensp
ENSP00000381812
resolver
ensp
ENSP00000486725
resolver
ensp
ENSP00000506144
resolver
ensp
ENSP00000506328
resolver
ensp
ENSP00000506368
resolver
ensp
ENSP00000506723
resolver
enst
ENST00000679580
resolver
genesymbol
PPIL2
resolver
hgnc
HGNC:9261
resolver
uniprot
A0A7P0TBL3
resolver
uniprot
A8K0I0
resolver
uniprot
Q13357
resolver
uniprot
Q8TAH2
resolver
uniprot
Q9BWR8
resolver
uniprot_entry
A0A7P0TBL3_HUMAN
resolver
uniprot_entry
A8K0I0_HUMAN
resolver
uniprot_entry
PPIL2_HUMAN
resolver
uniprot_sec
Q13357
resolver
uniprot_sec
Q8TAH2
resolver
uniprot_sec
Q9BWR8
resolver
amino_acid_sequence
MGKRQHQKDKMYITCAEYTHFYGGKKPDLPQTNFRRLPFDHCSLSLQPFVYPVCTPDGIVFDLLNIVPWLKKYGTNPSNGEKLDGRSLIKLNFSKNSEGKYHCPVLFTVFTNNTHIVAVRTTGNVYAYEAVEQLNIKAKNFRDLLTDEPFSRQDIITLQDPTNLDKFNVSNFYHVKNNMKIIDPDEEKAKQDPSYYLKNTNAETRETLQELYKEFKGDEILAATMKAPEKKKVDKLNAAHYSTGKVSASFTSTAMVPETTHEAAAIDEDVLRYQFVKKKGYVRLHTNKGDLNLELHCDLTPKTCENFIRLCKKHYYDGTIFHRSIRNFVIQGGDPTGTGTGGESYWGKPFKDEFRPNLSHTGRGILSMANSGPNSNRSQFFITFRSCAYLDKKHTIFGRVVGGFDVLTAMENVESDPKTDRPKEEIRIDATTVFVDPYEEADAQIAQERKTQLKVAPETKVKSSQPQAGSQGPQTFRQGVGKYINPAATKRAAEEEPSTSATVPMSKKKPSRGFGDFSSW
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Has a ubiquitin-protein ligase activity acting as an E3 ubiquitin protein ligase or as an ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates. By mediating 'Lys-48'-linked polyubiquitination of proteins could target them for proteasomal degradation (PubMed:11435423). May also function as a chaperone, playing a role in transport to the cell membrane of BSG/Basigin for instance (PubMed:15946952). Probable inactive PPIase with no peptidyl-prolyl cis-trans isomerase activity (PubMed:20676357). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs (Probable). {ECO:0000269|PubMed:11435423, ECO:0000269|PubMed:15946952, ECO:0000269|PubMed:20676357, ECO:0000305|PubMed:33509932}.
uniprot
proteins
mass_dalton
58823
uniprot
proteins
mutagenesis
MUTAGEN 389; /note="Y->H: No peptidyl-prolyl cis-trans isomerase activity; enables interaction with cyclosporin A."; /evidence="ECO:0000269|PubMed:20676357"; MUTAGEN 389; /note="Y->W: Gain of a peptidyl-prolyl cis-trans isomerase activity; enables interaction with cyclosporin A."; /evidence="ECO:0000269|PubMed:20676357
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:11435423}.
uniprot
proteins
protein_family
Cyclophilin-type PPIase family
uniprot
proteins
protein_family
PPIL2 subfamily
uniprot
proteins
pubmed
11435423
uniprot
proteins
pubmed
15189447
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15946952
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20676357
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
33509932
uniprot
proteins
pubmed
8660300
uniprot
proteins
sequence_length
520
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11435423, ECO:0000269|PubMed:8660300}. Note=May also localize to the cytoplasm and the cell membrane. {ECO:0000269|PubMed:15946952}.
uniprot
proteins