Arhgef4
entrez
226970
canonical
uniprot
Q7TNR9
canonical
ensembl
ENSMUSG00000037509
resolver
ensp
ENSMUSP00000035980
resolver
ensp
ENSMUSP00000124213
resolver
enst
ENSMUST00000047664
resolver
enst
ENSMUST00000159747
resolver
genesymbol
Arhgef4
resolver
genesymbol_syn
Kiaa1112
resolver
uniprot
E9PYK8
resolver
uniprot
Q3TQN9
resolver
uniprot
Q80TJ6
resolver
uniprot_entry
ARHG4_MOUSE
resolver
uniprot_entry
E9PYK8_MOUSE
resolver
uniprot_entry
Q3TQN9_MOUSE
resolver
uniprot_sec
Q80TJ6
resolver
amino_acid_sequence
MDDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRLRVNQDEPADDYEAPRAGAREADDSGPEAQSCKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKREDMFSEEQLRTIFGNIEDIYRCQKAFVKALEQKFNTERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLTKLSKYVYFFEACRLLQRMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKNVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIHSGELTRVTQPQARSQQRMFFLFDRQLIYCKKDLLRRDVLYYKGRLDMDDLEVVDVEDGKDRDLHVSVKNAFRLYCGTTGDSHLLCARKPEQKQRWLKAFAREREQVRLDQETGFSITELQRKQAMLNASKQQATGKPKAVGRPGYLTRHKHPSLPASRPQQQVLVLAEPRRKPSNFWHSISRLAPFRK
uniprot
proteins
function
FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Binding of APC may activate RAC1 GEF activity. The APC-ARHGEF4 complex seems to be involved in cell migration as well as in E-cadherin-mediated cell-cell adhesion (By similarity). Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. {ECO:0000250, ECO:0000269|PubMed:19893577}.
uniprot
proteins
mass_dalton
56679
uniprot
proteins
pubmed
10947987
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19893577
uniprot
proteins
sequence_length
484
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10947987}. Note=Colocalized with APC in the synapse of olfactory glomerulus.
uniprot
proteins