Rnf114
entrez
81018
canonical
uniprot
Q9ET26
canonical
ensembl
ENSMUSG00000006418
resolver
ensp
ENSMUSP00000077197
resolver
ensp
ENSMUSP00000104837
resolver
enst
ENSMUST00000078050
resolver
enst
ENSMUST00000109214
resolver
genesymbol
Rnf114
resolver
genesymbol_syn
Zfp228
resolver
genesymbol_syn
Zfp313
resolver
genesymbol_syn
Znf228
resolver
genesymbol_syn
Znf313
resolver
uniprot
Q3UFU8
resolver
uniprot
Q8K5A2
resolver
uniprot_entry
RN114_MOUSE
resolver
uniprot_sec
Q3UFU8
resolver
uniprot_sec
Q8K5A2
resolver
amino_acid_sequence
MAAAQPESRDGAAQSAKPASETDPLSRFTCPVCLEVFEKPVQVPCGHVFCSACLQECLKPKKPVCGVCRSALAPGVRAVELERQIESIETSCHGCRKNFILSKIRAHVTSCSKYQNYIMEGVKATTKDASLQPRNIPNRYTFPCPYCPEKNFDQEGLVEHCKLTHSTDTKSVVCPICASMPWGDPSYRSANFMEHIQRRHRFSYDTFVDYDVDEDDMINQVLQRSIIDQ
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates. In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity. Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3. May promote the ubiquitination of TRAF6 as well. Also acts as a negative regulator of T-cell activation. Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation. Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C. This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence. May play a role in spermatogenesis. {ECO:0000250|UniProtKB:Q9Y508}.
uniprot
proteins
mass_dalton
25745
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9Y508}.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. Polyubiquitinated in the presence of E2 enzymes UBE2D1, UBE2D2 and UBE2D3, but only monoubiquitinated in the presence of UBE2E1. {ECO:0000250|UniProtKB:Q9Y508}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28625874
uniprot
proteins
sequence_length
229
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Y508}. Nucleus {ECO:0000250|UniProtKB:Q9Y508}.
uniprot
proteins