Impact
entrez
497198
canonical
uniprot
Q5GFD9
canonical
ensembl
ENSRNOG00000045844
resolver
ensembl
ENSRNOG00055008556
resolver
ensembl
ENSRNOG00060009585
resolver
ensembl
ENSRNOG00065006651
resolver
ensp
ENSRNOP00000078372
resolver
ensp
ENSRNOP00000102236
resolver
ensp
ENSRNOP00055011563
resolver
ensp
ENSRNOP00060012689
resolver
ensp
ENSRNOP00065007520
resolver
enst
ENSRNOT00000116602
resolver
enst
ENSRNOT00055014456
resolver
enst
ENSRNOT00060016243
resolver
enst
ENSRNOT00065010288
resolver
genesymbol
Impact
resolver
uniprot_entry
IMPCT_RAT
resolver
amino_acid_sequence
MAEVESGSNQRQNEEIEAMAAIYGEEWCVIDEVAKIFCIRITDDMDDPKWTLCLQVMLPSEYPGTAPPVYQLNAPWLKGQERAELAKSLEEIYMKNIGESILYQWVEKIRDALIQKSQITEPGPDEKKKTEEEEVEGEDDPILEHPPENPVKTWDLKISESAPEAEELPPIAHGAPITDRRSTFQAHLAPVVCIDQVKKVLAKLYENKKIASATHNIYAYRIYCEDKQTFLQDSEDDGETAAGGRLLHLMEILNVKNVMVVVSRWYGGILLGPDRFKHINNCARNILVEKNFTNSPEESAKSFGKKKVKKDKKKGDH
uniprot
proteins
function
FUNCTION: Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth. {ECO:0000250|UniProtKB:O55091}.
uniprot
proteins
mass_dalton
35995
uniprot
proteins
protein_family
IMPACT family
uniprot
proteins
pubmed
15752730
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
317
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O55091}.
uniprot
proteins