EFNA1
entrez
1942
canonical
uniprot
P20827
canonical
ensembl
ENSG00000169242
resolver
ensp
ENSP00000357391
resolver
ensp
ENSP00000357392
resolver
genesymbol
EFNA1
resolver
genesymbol_syn
EPLG1
resolver
genesymbol_syn
LERK1
resolver
genesymbol_syn
TNFAIP4
resolver
hgnc
HGNC:3221
resolver
uniprot
D3DV86
resolver
uniprot
Q5SR60
resolver
uniprot
Q5SR61
resolver
uniprot
Q6I9T9
resolver
uniprot
Q8N578
resolver
uniprot_entry
EFNA1_HUMAN
resolver
uniprot_sec
D3DV86
resolver
uniprot_sec
Q5SR60
resolver
uniprot_sec
Q5SR61
resolver
uniprot_sec
Q6I9T9
resolver
uniprot_sec
Q8N578
resolver
amino_acid_sequence
MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPHYEDHSVADAAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSAKHGPEKLSEKFQRFTPFTLGKEFKEGHSYYYISKPIHQHEDRCLRLKVTVSGKITHSPQAHDNPQEKRLAADDPEVRVLHSIGHSAAPRLFPLAWTVLLLPLLLLQTP
uniprot
proteins
function
FUNCTION: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells (PubMed:17332925, PubMed:18794797). Involved in angiogenesis, regulating vascular endothelial cell differentiation and migration through activation of EPHA2. Acts as a ligand for EPHA3, inhibiting epithelial-to-mesenchymal transition of cardiac cells and playing a role in heart development (PubMed:12794130). May also contribute to dendritic spine morphogenesis (By similarity). {ECO:0000250|UniProtKB:P52793, ECO:0000269|PubMed:12794130, ECO:0000269|PubMed:17332925, ECO:0000269|PubMed:18794797}.
uniprot
proteins
mass_dalton
23787
uniprot
proteins
post_translational_modification
PTM: Undergoes proteolysis by a metalloprotease to give rise to a soluble monomeric form.; PTM: N-Glycosylation is required for binding to EPHA2 receptor and inducing its internalization. {ECO:0000269|PubMed:23661698}.
uniprot
proteins
protein_family
Ephrin family
uniprot
proteins
pubmed
12794130
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17332925
uniprot
proteins
pubmed
18794797
uniprot
proteins
pubmed
19525919
uniprot
proteins
pubmed
20505120
uniprot
proteins
pubmed
2233719
uniprot
proteins
pubmed
23661698
uniprot
proteins
pubmed
7838529
uniprot
proteins
sequence_length
205
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18794797}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:18794797}.; SUBCELLULAR LOCATION: [Ephrin-A1, secreted form]: Secreted {ECO:0000269|PubMed:18794797}.
uniprot
proteins