ADGRB2
entrez
576
canonical
uniprot
O60241
canonical
ensembl
ENSG00000121753
resolver
ensp
ENSP00000362759
resolver
ensp
ENSP00000362762
resolver
ensp
ENSP00000381548
resolver
ensp
ENSP00000381550
resolver
ensp
ENSP00000381555
resolver
ensp
ENSP00000381564
resolver
ensp
ENSP00000410921
resolver
ensp
ENSP00000435397
resolver
enst
ENST00000398542
resolver
genesymbol
ADGRB2
resolver
genesymbol_syn
BAI2
resolver
hgnc
HGNC:944
resolver
uniprot
A2A3C1
resolver
uniprot
B9EGK9
resolver
uniprot
Q5T6K0
resolver
uniprot
Q8NGW8
resolver
uniprot
Q96GZ9
resolver
uniprot_entry
A2A3C1_HUMAN
resolver
uniprot_entry
AGRB2_HUMAN
resolver
uniprot_sec
B9EGK9
resolver
uniprot_sec
Q5T6K0
resolver
uniprot_sec
Q8NGW8
resolver
uniprot_sec
Q96GZ9
resolver
activity_regulation
ACTIVITY REGULATION: Receptor activity is regulated by proteolytic processing. The long N-terminal has a an inhibitory effect on the constitutive signaling activity. Removal of the N-terminal region induces an increase of the receptor activity. {ECO:0000269|PubMed:20367554, ECO:0000269|PubMed:28891236}.
uniprot
proteins
amino_acid_sequence
MENTGWMGKGHRMTPACPLLLSVILSLRLATAFDPAPSACSALASGVLYGAFSLQDLFPTIASGCSWTLENPDPTKYSLYLRFNRQEQVCAHFAPRLLPLDHYLVNFTCLRPSPEEAVAQAESEVGRPEEEEAEAAAGLELCSGSGPFTFLHFDKNFVQLCLSAEPSEAPRLLAPAALAFRFVEVLLINNNNSSQFTCGVLCRWSEECGRAAGRACGFAQPGCSCPGEAGAGSTTTTSPGPPAAHTLSNALVPGGPAPPAEADLHSGSSNDLFTTEMRYGEEPEEEPKVKTQWPRSADEPGLYMAQTGDPAAEEWSPWSVCSLTCGQGLQVRTRSCVSSPYGTLCSGPLRETRPCNNSATCPVHGVWEEWGSWSLCSRSCGRGSRSRMRTCVPPQHGGKACEGPELQTKLCSMAACPVEGQWLEWGPWGPCSTSCANGTQQRSRKCSVAGPAWATCTGALTDTRECSNLECPATDSKWGPWNAWSLCSKTCDTGWQRRFRMCQATGTQGYPCEGTGEEVKPCSEKRCPAFHEMCRDEYVMLMTWKKAAAGEIIYNKCPPNASGSASRRCLLSAQGVAYWGLPSFARCISHEYRYLYLSLREHLAKGQRMLAGEGMSQVVRSLQELLARRTYYSGDLLFSVDILRNVTDTFKRATYVPSADDVQRFFQVVSFMVDAENKEKWDDAQQVSPGSVHLLRVVEDFIHLVGDALKAFQSSLIVTDNLVISIQREPVSAVSSDITFPMRGRRGMKDWVRHSEDRLFLPKEVLSLSSPGKPATSGAAGSPGRGRGPGTVPPGPGHSHQRLLPADPDESSYFVIGAVLYRTLGLILPPPRPPLAVTSRVMTVTVRPPTQPPAEPLITVELSYIINGTTDPHCASWDYSRADASSGDWDTENCQTLETQAAHTRCQCQHLSTFAVLAQPPKDLTLELAGSPSVPLVIGCAVSCMALLTLLAIYAAFWRFIKSERSIILLNFCLSILASNILILVGQSRVLSKGVCTMTAAFLHFFFLSSFCWVLTEAWQSYLAVIGRMRTRLVRKRFLCLGWGLPALVVAVSVGFTRTKGYGTSSYCWLSLEGGLLYAFVGPAAVIVLVNMLIGIIVFNKLMARDGISDKSKKQRAGSERCPWASLLLPCSACGAVPSPLLSSASARNAMASLWSSCVVLPLLALTWMSAVLAMTDRRSVLFQALFAVFNSAQGFVITAVHCFLRREVQDVVKCQMGVCRADESEDSPDSCKNGQLQILSDFEKDVDLACQTVLFKEVNTCNPSTITGTLSRLSLDEDEEPKSCLVGPEGSLSFSPLPGNILVPMAASPGLGEPPPPQEANPVYMCGEGGLRQLDLTWLRPTEPGSEGDYMVLPRRTLSLQPGGGGGGGEDAPRARPEGTPRRAAKTVAHTEGYPSFLSVDHSGLGLGPAYGSLQNPYGMTFQPPPPTPSARQVPEPGERSRTMPRTVPGSTMKMGSLERKKLRYSDLDFEKVMHTRKRHSELYHELNQKFHTFDRYRSQSTAKREKRWSVSSGGAAERSVCTDKPSPGERPSLSQHRRHQSWSTFKSMTLGSLPPKPRERLTLHRAAAWEPTEPPDGDFQTEV
uniprot
proteins
function
FUNCTION: Orphan G protein-coupled receptor involved in cell adhesion and probably in cell-cell interactions. Activates NFAT-signaling pathway, a transcription factor, via the G protein GNAZ (PubMed:20367554, PubMed:28891236). Involved in angiogenesis inhibition (By similarity). {ECO:0000250|UniProtKB:Q8CGM1, ECO:0000269|PubMed:20367554, ECO:0000269|PubMed:28891236}.
uniprot
proteins
mass_dalton
172656
uniprot
proteins
mutagenesis
MUTAGEN 889; /note="W->S: Inhibits autoproteolytic cleavage."; /evidence="ECO:0000269|PubMed:20367554"; MUTAGEN 908; /note="C->W: Inhibits autoproteolytic cleavage."; /evidence="ECO:0000269|PubMed:20367554"; MUTAGEN 912; /note="S->P: Inhibits autoproteolytic cleavage."; /evidence="ECO:0000269|PubMed:20367554
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:20367554}.; PTM: Autoproteolytically processed at the GPS region of the GAIN-B domain; this cleavage modulates receptor activity (By similarity). Additionally, furin is involved in the cleavage at another site, in the middle of the extracellular domain, generating a soluble fragment. {ECO:0000255|PROSITE-ProRule:PRU00098, ECO:0000269|PubMed:20367554}.
uniprot
proteins
protein_family
Adhesion G protein-coupled receptor (ADGR) subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
20367554
uniprot
proteins
pubmed
21787750
uniprot
proteins
pubmed
25326458
uniprot
proteins
pubmed
25713288
uniprot
proteins
pubmed
28891236
uniprot
proteins
pubmed
9533023
uniprot
proteins
sequence_length
1585
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28891236}; Multi-pass membrane protein {ECO:0000255}. Secreted {ECO:0000269|PubMed:25326458}.
uniprot
proteins
transmembrane_region
TRANSMEM 937..957; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 966..986; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 995..1015; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 1037..1057; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 1079..1099; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 1122..1142; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 1154..1174; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins