BABAM1
entrez
29086
canonical
uniprot
Q9NWV8
canonical
ensembl
ENSG00000105393
resolver
ensp
ENSP00000352408
resolver
ensp
ENSP00000407826
resolver
ensp
ENSP00000468834
resolver
ensp
ENSP00000470920
resolver
ensp
ENSP00000471605
resolver
ensp
ENSP00000533436
resolver
ensp
ENSP00000592170
resolver
ensp
ENSP00000592175
resolver
ensp
ENSP00000592176
resolver
ensp
ENSP00000592183
resolver
ensp
ENSP00000592189
resolver
enst
ENST00000447614
resolver
enst
ENST00000595632
resolver
enst
ENST00000863377
resolver
enst
ENST00000922111
resolver
enst
ENST00000922116
resolver
enst
ENST00000922117
resolver
enst
ENST00000922124
resolver
enst
ENST00000922130
resolver
genesymbol
BABAM1
resolver
genesymbol_syn
C19orf62
resolver
genesymbol_syn
MERIT40
resolver
genesymbol_syn
NBA1
resolver
hgnc
HGNC:25008
resolver
uniprot
A8MQT0
resolver
uniprot
B4DRY9
resolver
uniprot
B4DVR1
resolver
uniprot
J3KQS6
resolver
uniprot
M0QX07
resolver
uniprot
Q6FIA0
resolver
uniprot
Q9P018
resolver
uniprot_entry
BABA1_HUMAN
resolver
uniprot_entry
J3KQS6_HUMAN
resolver
uniprot_sec
A8MQT0
resolver
uniprot_sec
B4DRY9
resolver
uniprot_sec
B4DVR1
resolver
uniprot_sec
M0QX07
resolver
uniprot_sec
Q6FIA0
resolver
uniprot_sec
Q9P018
resolver
amino_acid_sequence
MEVAEPSSPTEEEEEEEEHSAEPRPRTRSNPEGAEDRAVGAQASVGSRSEGEGEAASADDGSLNTSGAGPKSWQVPPPAPEVQIRTPRVNCPEKVIICLDLSEEMSLPKLESFNGSKTNALNVSQKMIEMFVRTKHKIDKSHEFALVVVNDDTAWLSGLTSDPRELCSCLYDLETASCSTFNLEGLFSLIQQKTELPVTENVQTIPPPYVVRTILVYSRPPCQPQFSLTEPMKKMFQCPYFFFDVVYIHNGTEEKEEEMSWKDMFAFMGSLDTKGTSYKYEVALAGPALELHNCMAKLLAHPLQRPCQSHASYSLLEEEDEAIEVEATV
uniprot
proteins
function
FUNCTION: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:24075985, PubMed:26195665). In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). {ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749}.
uniprot
proteins
mass_dalton
36560
uniprot
proteins
protein_family
BABAM1 family
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19214193
uniprot
proteins
pubmed
19261746
uniprot
proteins
pubmed
19261748
uniprot
proteins
pubmed
19261749
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21282113
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24075985
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25283148
uniprot
proteins
pubmed
26195665
uniprot
proteins
sequence_length
329
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19261749, ECO:0000269|PubMed:24075985}. Nucleus {ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749, ECO:0000269|PubMed:21282113, ECO:0000269|PubMed:24075985}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). {ECO:0000269|PubMed:19261746, ECO:0000269|PubMed:19261748, ECO:0000269|PubMed:19261749, ECO:0000269|PubMed:21282113}.
uniprot
proteins