PLCH2
entrez
9651
canonical
uniprot
O75038
canonical
ensembl
ENSG00000149527
resolver
ensembl
ENSG00000276429
resolver
ensp
ENSP00000367747
resolver
ensp
ENSP00000397289
resolver
genesymbol
PLCH2
resolver
genesymbol_syn
KIAA0450
resolver
genesymbol_syn
PLCL4
resolver
hgnc
HGNC:29037
resolver
uniprot
A2VCM3
resolver
uniprot
B9DI80
resolver
uniprot
Q3LUA8
resolver
uniprot
Q86XJ2
resolver
uniprot
Q86XU1
resolver
uniprot
Q86YU7
resolver
uniprot
Q8TEH5
resolver
uniprot
Q8WUS6
resolver
uniprot_entry
PLCH2_HUMAN
resolver
uniprot_sec
A2VCM3
resolver
uniprot_sec
B9DI80
resolver
uniprot_sec
Q3LUA8
resolver
uniprot_sec
Q86XJ2
resolver
uniprot_sec
Q86XU1
resolver
uniprot_sec
Q86YU7
resolver
uniprot_sec
Q8TEH5
resolver
uniprot_sec
Q8WUS6
resolver
activity_regulation
ACTIVITY REGULATION: Activity is stimulated by GNB1:GNG2. {ECO:0000269|PubMed:18361507}.
uniprot
proteins
amino_acid_sequence
MSGPWPSPDSRTKGTVAWLAEVLLWVGGSVVLSSEWQLGPLVERCMGAMQEGMQMVKLRGGSKGLVRFYYLDEHRSCIRWRPSRKNEKAKISIDSIQEVSEGRQSEVFQRYPDGSFDPNCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGVTLESCQDIIEQFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEIDDDCKLLNGDASTNRKRVENTAKRKLDSLIKESKIRDCEDPNNFSVSTLSPSGKLGRKSKAEEDVESGEDAGASRRNGRLVVGSFSRRKKKGSKLKKAASVEEGDEGQDSPGGQSRGATRQKKTMKLSRALSDLVKYTKSVATHDIEMEAASSWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCMCQGVFNPNSEDPLPGQLKKQLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVVDDNGFNPTWEETLVFMVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQALGLKGLFLRGPKPGSLDSHAAGRPPARPSVSQRILRRTASAPTKSQKPGRRGFPELVLGTRDTGSKGVADDVVPPGPGPAPEAPAQEGPGSGSPRDTRPLSTQRPLPPLCSLETIAEEPAPGPGPPPPAAVPTSSSQGRPPYPTGPGANVASPLEDTEEPRDSRPRPCNGEGAGGAYERAPGSQTDGRSQPRTLGHLPVIRRVKSEGQVPTEPLGGWRPLAAPFPAPAVYSDATGSDPLWQRLEPCGHRDSVSSSSSMSSSDTVIDLSLPSLGLGRSRENLAGAHMGRLPPRPHSASAARPDLPPVTKSKSNPNLRATGQRPPIPDELQPRSLAPRMAGLPFRPPWGCLSLVGVQDCPVAAKSKSLGDLTADDFAPSFEGGSRRLSHSLGLPGGTRRVSGPGVRRDTLTEQLRWLTVFQQAGDITSPTSLGPAGEGVAGGPGFVRRSSSRSHSRVRAIASRARQAQERQQRLQGLGRQGPPEEERGTPEGACSVGHEGSVDAPAPSKGALGPASAAAENLVLLRL
uniprot
proteins
ec_number
3.1.4.11
uniprot
proteins
function
FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (PubMed:18361507). This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain (By similarity). {ECO:0000250|UniProtKB:A2AP18, ECO:0000269|PubMed:18361507}.
uniprot
proteins
mass_dalton
154668
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16107206
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18361507
uniprot
proteins
pubmed
9455484
uniprot
proteins
sequence_length
1416
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A2AP18}. Cell membrane {ECO:0000250|UniProtKB:A2AP18}; Peripheral membrane protein {ECO:0000250|UniProtKB:A2AP18}; Cytoplasmic side {ECO:0000250|UniProtKB:A2AP18}. Note=Localized predominantly at the plasma membrane through the PH domain. {ECO:0000250|UniProtKB:A2AP18}.
uniprot
proteins