PLEKHA1
entrez
59338
canonical
uniprot
Q9HB21
canonical
ensembl
ENSG00000107679
resolver
ensp
ENSP00000357985
resolver
ensp
ENSP00000357986
resolver
ensp
ENSP00000376547
resolver
ensp
ENSP00000548274
resolver
ensp
ENSP00000548275
resolver
ensp
ENSP00000548280
resolver
ensp
ENSP00000548281
resolver
ensp
ENSP00000548284
resolver
ensp
ENSP00000548285
resolver
ensp
ENSP00000548288
resolver
ensp
ENSP00000663681
resolver
ensp
ENSP00000663683
resolver
ensp
ENSP00000663686
resolver
ensp
ENSP00000663687
resolver
ensp
ENSP00000663688
resolver
ensp
ENSP00000663690
resolver
ensp
ENSP00000704894
resolver
ensp
ENSP00000704895
resolver
ensp
ENSP00000704902
resolver
ensp
ENSP00000786164
resolver
ensp
ENSP00000789845
resolver
ensp
ENSP00000789846
resolver
ensp
ENSP00000797140
resolver
enst
ENST00000368989
resolver
genesymbol
PLEKHA1
resolver
genesymbol_syn
TAPP1
resolver
hgnc
HGNC:14335
resolver
uniprot
B3KQ55
resolver
uniprot
B3KQL5
resolver
uniprot
D3DRE2
resolver
uniprot
Q5RGS4
resolver
uniprot
Q9BVK0
resolver
uniprot_entry
B3KQL5_HUMAN
resolver
uniprot_entry
PKHA1_HUMAN
resolver
uniprot_entry
Q5RGS4_HUMAN
resolver
uniprot_sec
B3KQ55
resolver
uniprot_sec
D3DRE2
resolver
uniprot_sec
Q9BVK0
resolver
amino_acid_sequence
MPYVDRQNRICGFLDIEENENSGKFLRRYFILDTREDSFVWYMDNPQNLPSGSSRVGAIKLTYISKVSDATKLRPKAEFCFVMNAGMRKYFLQANDQQDLVEWVNVLNKAIKITVPKQSDSQPNSDNLSRHGECGKKQVSYRTDIVGGVPIITPTQKEEVNECGESIDRNNLKRSQSHLPYFTPKPPQDSAVIKAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPLKEVHKVQECKQSDIMMRDNLFEIVTTSRTFYVQADSPEEMHSWIKAVSGAIVAQRGPGRSASSEHPPGPSESKHAFRPTNAATATSHSTASRSNSLVSTFTMEKRGFYESLAKVKPGNFKVQTVSPREPASKVTEQALLRPQSKNGPQEKDCDLVDLDDASLPVSDV
uniprot
proteins
function
FUNCTION: Binds specifically to phosphatidylinositol 3,4-diphosphate (PtdIns3,4P2), but not to other phosphoinositides. May recruit other proteins to the plasma membrane. {ECO:0000269|PubMed:11001876, ECO:0000269|PubMed:11513726, ECO:0000269|PubMed:14516276}.
uniprot
proteins
mass_dalton
45553
uniprot
proteins
mutagenesis
MUTAGEN 28; /note="R->L: No effect on phosphatidylinositide binding."; /evidence="ECO:0000269|PubMed:11001876"; MUTAGEN 203..205; /note="AVM->GGG: Abolishes phosphatidylinositide binding."; MUTAGEN 203..205; /note="AVM->GLV: Binds both PtdIns3,4P2 and PtdIns3,4,5P3."; MUTAGEN 203..204; /note="AV->GG: Binds both PtdIns3,4P2 and PtdIns3,4,5P3."; MUTAGEN 203; /note="A->G: Binds both PtdIns3,4P2 and PtdIns3,4,5P3."; /evidence="ECO:0000269|PubMed:11513726"; MUTAGEN 204; /note="V->L: No effect."; /evidence="ECO:0000269|PubMed:11513726"; MUTAGEN 205; /note="M->V: No effect."; /evidence="ECO:0000269|PubMed:11513726"; MUTAGEN 207; /note="N->T: No effect."; /evidence="ECO:0000269|PubMed:11513726"; MUTAGEN 211; /note="R->L: Abolishes phosphatidylinositide binding."; /evidence="ECO:0000269|PubMed:11001876
uniprot
proteins
pubmed
11001876
uniprot
proteins
pubmed
11513726
uniprot
proteins
pubmed
11802782
uniprot
proteins
pubmed
12101241
uniprot
proteins
pubmed
14516276
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
404
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11802782, ECO:0000269|PubMed:12101241}. Cell membrane {ECO:0000269|PubMed:11802782, ECO:0000269|PubMed:12101241}; Peripheral membrane protein. Nucleus {ECO:0000269|PubMed:11802782, ECO:0000269|PubMed:12101241}. Note=Locates to the plasma membrane after treatments that stimulate the production of PtdIns3,4P2. {ECO:0000269|PubMed:11802782}.
uniprot
proteins