Nek1
entrez
18004
canonical
uniprot
P51954
canonical
ensembl
ENSMUSG00000031644
resolver
ensp
ENSMUSP00000034065
resolver
ensp
ENSMUSP00000113932
resolver
ensp
ENSMUSP00000147258
resolver
ensp
ENSMUSP00000147809
resolver
ensp
ENSMUSP00000301066
resolver
ensp
ENSMUSP00000301067
resolver
enst
ENSMUST00000034065
resolver
enst
ENSMUST00000120689
resolver
enst
ENSMUST00000211256
resolver
enst
ENSMUST00000211672
resolver
genesymbol
Nek1
resolver
uniprot
A0A1B0GQU9
resolver
uniprot
A0A1B0GS64
resolver
uniprot
B2RXQ4
resolver
uniprot
B2RXX0
resolver
uniprot
B7ZWK0
resolver
uniprot
F7CS52
resolver
uniprot
Q3UXI0
resolver
uniprot_entry
A0A1B0GQU9_MOUSE
resolver
uniprot_entry
A0A1B0GS64_MOUSE
resolver
uniprot_entry
B2RXQ4_MOUSE
resolver
uniprot_entry
B2RXX0_MOUSE
resolver
uniprot_entry
B7ZWK0_MOUSE
resolver
uniprot_entry
F7CS52_MOUSE
resolver
uniprot_entry
NEK1_MOUSE
resolver
uniprot_entry
Q3UXI0_MOUSE
resolver
amino_acid_sequence
MEKYVRLQKIGEGSFGKAVLVKSTEDGRHYVIKEINISRMSDKERQESRREVAVLANMKHPNIVQYKESFEENGSLYIVMDYCEGGDLFKRINAQKGALFQEDQILDWFVQICLALKHVHDRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGNMKNLVLKIISGSFPPVSPHYSYDLRSLLSQLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEEFCLKTLSKFGPQPLPGKRPASGQGVSSFVPAQKITKPAAKYGVPLTYKKYGDKKLLEKKPPPKHKQAHQIPVKKMNSGEERKKMSEEAAKKRRLEFIEKEKKQKDQIRFLKAEQMKRQEKQRLERINRAREQGWRNVLRAGGSGEVKASFFGIGGAVSPSPCSPRGQYEHYHAIFDQMQRLRAEDNEARWKGGIYGRWLPERQKGHLAVERANQVEEFLQRKREAMQNKARAEGHVVYLARLRQIRLQNFNERQQIKAKLRGENKEADGTKGQEATEETDMRLKKMESLKAQTNARAAVLKEQLERKRKEAYEREKKVWEEHLVARVKSSDVPLPLELLETGGSPSKQQVKPVISVTSALKEVGLDGSLTDTQEEEMEKSNSAISSKREILRRLNENLKAQEDEKEKQHHSGSCETVGHKDEREYETENAISSDRKKWEMGGQLVIPLDAVTLDTSFSATEKHTVGEVIKLDSNGSPRKVWGKNPTDSVLKILGEAELQLQTELLENTSFKSEVYAEEENYKPLLTEEENLQCISKEINPSATVDSTETKSPKFTEVSPQMSEGNVEEPDDLETEVLQEPSSTHTDGSLPPVLNDVWTREKEAAKETELEDKVAVQQSEVCEDRIPGNVDQSCKDQRDPAVDDSPQSGCDVEKSVQPESIFQKVVHSKDLNLVQAVHCSPEEPIPIRSHSDSPPKTKSKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVHQDSLEIDELEDEPIKEGPSDSEDTVFEETDTDLQELQASMEQLLREQPGDEYSEEEESVLKSSDVEQTARGTDAPDEEDNPSSESALNEEWHSDNSDAETTSECEYDSVFNHLEELRLHLEQEMGFEKFFEVYEKVKAIHEDEDENIEICSTIVENILGNEHQHLYAKILHLVMADGAYQEDNDE
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity (PubMed:1382974). Involved in DNA damage checkpoint control and for proper DNA damage repair (PubMed:18843199). In response to injury that includes DNA damage, NEK1 phosphorylates VDAC1 to limit mitochondrial cell death (By similarity). May be implicated in the control of meiosis (PubMed:1382974). Involved in cilium assembly (By similarity). {ECO:0000250|UniProtKB:Q96PY6, ECO:0000269|PubMed:1382974, ECO:0000269|PubMed:18843199}.
uniprot
proteins
mass_dalton
136690
uniprot
proteins
mutagenesis
MUTAGEN 997; /note="S->A: Loss of 14-3-3 protein-binding."; /evidence="ECO:0000269|PubMed:28235073
uniprot
proteins
protein_family
NEK Ser/Thr protein kinase family
uniprot
proteins
protein_family
NIMA subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
12204287
uniprot
proteins
pubmed
1382974
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
16267153
uniprot
proteins
pubmed
18843199
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28235073
uniprot
proteins
sequence_length
1203
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:16267153}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:16267153}. Note=Associated with the pericentriolar material (By similarity). Localizes to centrosome during interphase and mitosis (PubMed:16267153). {ECO:0000250|UniProtKB:Q96PY6, ECO:0000269|PubMed:16267153}.
uniprot
proteins