Os9
entrez
216440
canonical
uniprot
Q8K2C7
canonical
ensembl
ENSMUSG00000040462
resolver
ensp
ENSMUSP00000079770
resolver
ensp
ENSMUSP00000128914
resolver
genesymbol
Os9
resolver
uniprot_entry
OS9_MOUSE
resolver
amino_acid_sequence
MAAEVLLSSLLGLLFLGLLLPARLTGGVGSLNLEELSEMRYGIQILPLPVMGGQSQASDVVVVSSKYKQRYECRLPAGAIHFQREREEETPAYQGPGIPELLSPMRDAPCLLKTKDWWTYEFCYGRHIQQYHMEDSEIKGDVLYLGHYQSSFNWDDETAKASKQHRLKRYHSQTYGNGSKCDLNGKPREAEVRFLCDEGAGISGDYIDRVDEPVSCSYVLTIRTSRLCPHPLLRPPASAAPQAILCHPALQPDEYMAYLQRQAESKQHEEKTTEEVQDTDRQVWSGSKAAGAPPKKEDVSPAKEEKESELWKLQGPEEQAAAREEAQAGEQDLNHEAAADPAPSPPNDFQNNVQVKLIRSPADLIRLIEELKAAEKGKPSVRREQPGDDTTEAPQREAEGTKAKGKDGEPPGLMEEEDGDDEEEEEEEEEDEEEQQLLGEFEKELEGMLLPSNRERLRSEVKAGMERELENIIQETEKELDPEGLRKESEREQAILALTSTLDKLIKRLQENQSPELVQKYKKRRVVPQKPPPSPHPTEEEPEHRVRVRVTKLRPGGPNRDLTVLEMNRENPQLKQIEGLVTEVLEREGLTAEGKIEIKIVRPGAEGKEEDTRWLTDEDTRNLKEIFFNILVQGAEEANKERQRQSELESNYRRVWGSPGGEDTGDLDEFDF
uniprot
proteins
function
FUNCTION: Lectin component of the HRD1 complex, which functions in endoplasmic reticulum (ER) quality control and ER-associated degradation (ERAD). Specifically recognizes and binds improperly folded glycoproteins as well as hyperglycosylated proteins, retain them in the ER, and transfers them to the ubiquitination machinery and promote their degradation. Possible targets include TRPV4 as well as hyperglycosylated HSP90B1. {ECO:0000250|UniProtKB:Q13438}.
uniprot
proteins
mass_dalton
76108
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:19084021}.; PTM: Intramolecular disulfide bonds. {ECO:0000250|UniProtKB:Q13438}.
uniprot
proteins
protein_family
OS-9 family
uniprot
proteins
pubmed
10403379
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19084021
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
672
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:Q13438}.
uniprot
proteins