Cbx7
entrez
362962
canonical
uniprot
P60889
canonical
ensembl
ENSRNOG00000016875
resolver
ensp
ENSRNOP00000022631
resolver
ensp
ENSRNOP00000074584
resolver
enst
ENSRNOT00000022631
resolver
enst
ENSRNOT00000077731
resolver
genesymbol
Cbx7
resolver
uniprot
A0A8L2QCQ7
resolver
uniprot
A0A8L2UR72
resolver
uniprot_entry
A0A8L2QCQ7_RAT
resolver
uniprot_entry
A0A8L2UR72_RAT
resolver
uniprot_entry
CBX7_RAT
resolver
amino_acid_sequence
MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEEKDRASGYRKRGPKPKRLLLQESAAPDVLQATGDWEPVEQPPEEEAEADLTNGPPPWTPMLPSSEVTVTDITANSVTVTFREAQAAEGFFRDRSGKL
uniprot
proteins
function
FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to histone H3 trimethylated 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3). May possibly also bind trimethylated lysine residues in other proteins (in vitro). Binds non-coding, single-stranded and double-stranded RNA. Plays a role in the timely repression of differentiation-specific genes in pluripotent embryonic stem cells to maintain the undifferentiated state. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity (By similarity). {ECO:0000250|UniProtKB:Q8VDS3}.
uniprot
proteins
mass_dalton
17966
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
158
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8VDS3}. Chromosome {ECO:0000250|UniProtKB:Q8VDS3}. Note=Requires trimethylation at 'Lys-27' (H3K27me3) for the localization to chromatin. Localizes to facultative heterochromatin and to the inactivated X chromosome in females. {ECO:0000250|UniProtKB:Q8VDS3}.
uniprot
proteins