REG3A
entrez
5068
canonical
uniprot
Q06141
canonical
ensembl
ENSG00000172016
resolver
ensp
ENSP00000304311
resolver
ensp
ENSP00000377456
resolver
ensp
ENSP00000386630
resolver
enst
ENST00000305165
resolver
enst
ENST00000393878
resolver
enst
ENST00000409839
resolver
genesymbol
REG3A
resolver
genesymbol_syn
HIP
resolver
genesymbol_syn
PAP
resolver
genesymbol_syn
PAP1
resolver
hgnc
HGNC:8601
resolver
uniprot
D6W5K0
resolver
uniprot
Q53S56
resolver
uniprot_entry
Q53S56_HUMAN
resolver
uniprot_entry
REG3A_HUMAN
resolver
uniprot_sec
D6W5K0
resolver
activity_regulation
ACTIVITY REGULATION: [Regenerating islet-derived protein 3-alpha 15 kDa form]: Lipopolysaccharide inhibits pore-forming activity, explaining why is bactericidal for Gram-positive but not Gram-negative bacteria. {ECO:0000269|PubMed:24256734}.
uniprot
proteins
amino_acid_sequence
MLPPMALPSVSWMLLSCLMLLSQVQGEEPQRELPSARIRCPKGSKAYGSHCYALFLSPKSWTDADLACQKRPSGNLVSVLSGAEGSFVSSLVKSIGNSYSYVWIGLHDPTQGTEPNGEGWEWSSSDVMNYFAWERNPSTISSPGHCASLSRSTAFLRWKDYNCNVRLPYVCKFTD
uniprot
proteins
function
FUNCTION: [Regenerating islet-derived protein 3-alpha 15 kDa form]: Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan (PubMed:16931762). Binds membrane phospholipids and kills bacteria by forming a hexameric membrane-permeabilizing oligomeric pore (PubMed:24256734). {ECO:0000269|PubMed:16931762, ECO:0000269|PubMed:24256734}.; FUNCTION: Acts as a hormone in response to different stimuli like anti-inflammatory signals, such as IL17A, or gut microbiome. Secreted by different cell types to activate its receptor EXTL3 and induce cell specific signaling pathways (PubMed:19158046, PubMed:22727489, PubMed:27830702, PubMed:34099862). Induced by IL17A in keratinocytes, regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway (PubMed:22727489). In parallel, inhibits skin inflammation through the inhibition of inflammatory cytokines such as IL6 and TNF (PubMed:27830702). In pancreas, is able to permealize beta-cells membrane and stimulate their proliferation (PubMed:19158046). {ECO:0000269|PubMed:19158046, ECO:0000269|PubMed:22727489, ECO:0000269|PubMed:27830702, ECO:0000269|PubMed:34099862}.; FUNCTION: [Regenerating islet-derived protein 3-alpha 16.5 kDa form]: Has bacteriostatic activity. {ECO:0000305|PubMed:24256734}.
uniprot
proteins
mass_dalton
19395
uniprot
proteins
mutagenesis
MUTAGEN 93; /note="K->A: Reduces binding to phospholipids and membrane toxicity. Loss of filament formation."; /evidence="ECO:0000269|PubMed:24256734"; MUTAGEN 93; /note="K->Q,H: No effect on binding to phospholipids and membrane toxicity."; /evidence="ECO:0000269|PubMed:24256734"; MUTAGEN 114; /note="E->Q: Reduces peptidoglycan binding and antibacterial activity. No effect on binding to phospholipids and membrane toxicity. No effect on filament formation."; /evidence="ECO:0000269|PubMed:20382864, ECO:0000269|PubMed:24256734"; MUTAGEN 118; /note="E->Q: Reduces antibacterial activity but no effect on peptidoglycan binding."; /evidence="ECO:0000269|PubMed:20382864"; MUTAGEN 166; /note="R->A: Reduces membrane toxicity."; /evidence="ECO:0000269|PubMed:24256734
uniprot
proteins
post_translational_modification
PTM: Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity. {ECO:0000269|PubMed:19254208}.
uniprot
proteins
pubmed
1325291
uniprot
proteins
pubmed
1469087
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16931762
uniprot
proteins
pubmed
19158046
uniprot
proteins
pubmed
19254208
uniprot
proteins
pubmed
20382864
uniprot
proteins
pubmed
22727489
uniprot
proteins
pubmed
24256734
uniprot
proteins
pubmed
27830702
uniprot
proteins
pubmed
34099862
uniprot
proteins
pubmed
7679928
uniprot
proteins
pubmed
8076648
uniprot
proteins
pubmed
8188210
uniprot
proteins
sequence_length
175
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1469087}. Note=Found in the apical region of pancreatic acinar cells. {ECO:0000269|PubMed:1469087}.
uniprot
proteins