CCNB1
entrez
891
canonical
uniprot
P14635
canonical
ensembl
ENSG00000134057
resolver
ensp
ENSP00000256442
resolver
ensp
ENSP00000424588
resolver
ensp
ENSP00000594479
resolver
genesymbol
CCNB1
resolver
genesymbol_syn
CCNB
resolver
hgnc
HGNC:1579
resolver
uniprot
A8K066
resolver
uniprot
Q5TZP9
resolver
uniprot_entry
CCNB1_HUMAN
resolver
uniprot_sec
A8K066
resolver
uniprot_sec
Q5TZP9
resolver
amino_acid_sequence
MALRVTRNSKINAENKAKINMAGAKRVPTAPAATSKPGLRPRTALGDIGNKVSEQLQAKMPMKKEAKPSATGKVIDKKLPKPLEKVPMLVPVPVSEPVPEPEPEPEPEPVKEEKLSPEPILVDTASPSPMETSGCAPAEEDLCQAFSDVILAVNDVDAEDGADPNLCSEYVKDIYAYLRQLEEEQAVRPKYLLGREVTGNMRAILIDWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTKHQIRQMEMKILRALNFGLGRPLPLHFLRRASKIGEVDVEQHTLAKYLMELTMLDYDMVHFPPSQIAAGAFCLALKILDNGEWTPTLQHYLSYTEESLLPVMQHLAKNVVMVNQGLTKHMTVKNKYATSKHAKISTLPQLNSALVQDLAKAVAKV
uniprot
proteins
function
FUNCTION: Essential for the control of the cell cycle at the G2/M (mitosis) transition (PubMed:27030811, PubMed:17495531, PubMed:17495533). Binds and activates cyclin-dependent protein kinase CDK1/CDC2 (PubMed:41100585). {ECO:0000269|PubMed:17495531, ECO:0000269|PubMed:17495533, ECO:0000269|PubMed:27030811, ECO:0000269|PubMed:41100585}.
uniprot
proteins
mass_dalton
48337
uniprot
proteins
mutagenesis
MUTAGEN 133; /note="S->A: Strongly impairs phosphorylation by PLK1."; /evidence="ECO:0000269|PubMed:12447691, ECO:0000269|PubMed:12524548"; MUTAGEN 147; /note="S->A: Does not affect phosphorylation by PLK1."; /evidence="ECO:0000269|PubMed:12524548
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction (PubMed:16009132). Deubiquitinated by USP22 during G2/M phase (PubMed:27030811). {ECO:0000269|PubMed:16009132, ECO:0000269|PubMed:27030811}.; PTM: Phosphorylated by PLK1 at Ser-133 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear import. Phosphorylation at Ser-147 was also reported to be mediated by PLK1 but Ser-133 seems to be the primary phosphorylation site. {ECO:0000269|PubMed:12447691, ECO:0000269|PubMed:12524548}.
uniprot
proteins
protein_family
Cyclin AB subfamily
uniprot
proteins
protein_family
Cyclin family
uniprot
proteins
pubmed
10716937
uniprot
proteins
pubmed
12447691
uniprot
proteins
pubmed
12524548
uniprot
proteins
pubmed
12612082
uniprot
proteins
pubmed
12775724
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15181148
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15790566
uniprot
proteins
pubmed
16009132
uniprot
proteins
pubmed
17495531
uniprot
proteins
pubmed
17495533
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21540187
uniprot
proteins
pubmed
2570636
uniprot
proteins
pubmed
27030811
uniprot
proteins
pubmed
41100585
uniprot
proteins
pubmed
7843284
uniprot
proteins
sequence_length
433
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
uniprot
proteins