CSNK1E
entrez
1454
canonical
uniprot
P49674
canonical
ensembl
ENSG00000213923
resolver
ensembl
ENSG00000283900
resolver
ensp
ENSP00000352929
resolver
ensp
ENSP00000380044
resolver
ensp
ENSP00000383067
resolver
ensp
ENSP00000384074
resolver
ensp
ENSP00000557385
resolver
ensp
ENSP00000557386
resolver
ensp
ENSP00000557387
resolver
ensp
ENSP00000592739
resolver
ensp
ENSP00000592740
resolver
ensp
ENSP00000592742
resolver
ensp
ENSP00000592744
resolver
ensp
ENSP00000592745
resolver
ensp
ENSP00000637589
resolver
ensp
ENSP00000637591
resolver
ensp
ENSP00000637592
resolver
ensp
ENSP00000637593
resolver
ensp
ENSP00000637594
resolver
enst
ENST00000359867
resolver
enst
ENST00000396832
resolver
enst
ENST00000400206
resolver
enst
ENST00000403904
resolver
enst
ENST00000887326
resolver
enst
ENST00000887327
resolver
enst
ENST00000887328
resolver
enst
ENST00000922680
resolver
enst
ENST00000922681
resolver
enst
ENST00000922683
resolver
enst
ENST00000922685
resolver
enst
ENST00000922686
resolver
enst
ENST00000967530
resolver
enst
ENST00000967532
resolver
enst
ENST00000967533
resolver
enst
ENST00000967534
resolver
enst
ENST00000967535
resolver
genesymbol
CSNK1E
resolver
hgnc
HGNC:2453
resolver
uniprot
Q5U045
resolver
uniprot_entry
KC1E_HUMAN
resolver
uniprot_entry
Q5U045_HUMAN
resolver
activity_regulation
ACTIVITY REGULATION: Phosphorylation leads to a decrease of the catalytic activity. {ECO:0000269|PubMed:16790549}.
uniprot
proteins
amino_acid_sequence
MELRVGNKYRLGRKIGSGSFGDIYLGANIASGEEVAIKLECVKTKHPQLHIESKFYKMMQGGVGIPSIKWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFSTYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGAARNPEDVDRERREHEREERMGQLRGSATRALPPGPPTGATANRLRSAAEPVASTPASRIQPAGNTSPRAISRVDRERKVSMRLHRGAPANVSSSDLTGRQEVSRIPASQTSVPFDHLGK
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (Probable). Participates in Wnt signaling (PubMed:12556519, PubMed:23413191). Phosphorylates DVL1 (PubMed:12556519). Phosphorylates DVL2 (PubMed:23413191). Phosphorylates NEDD9/HEF1 (By similarity). Central component of the circadian clock (PubMed:16790549). In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation (PubMed:15917222, PubMed:16790549). Controls PER1 and PER2 nuclear transport and degradation (By similarity). Inhibits cytokine-induced granuloytic differentiation (PubMed:15070676). {ECO:0000250|UniProtKB:Q9JMK2, ECO:0000269|PubMed:12556519, ECO:0000269|PubMed:15070676, ECO:0000269|PubMed:15917222, ECO:0000269|PubMed:16790549, ECO:0000269|PubMed:23413191, ECO:0000305|PubMed:7797465}.
uniprot
proteins
mass_dalton
47315
uniprot
proteins
mutagenesis
MUTAGEN 38; /note="K->R: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:29222110
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. Partially dephosphorylated by PPP5C. May be dephosphorylated by PP1.
uniprot
proteins
protein_family
CK1 Ser/Thr protein kinase family
uniprot
proteins
protein_family
Casein kinase I subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
10790862
uniprot
proteins
pubmed
12556519
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
15070676
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15917222
uniprot
proteins
pubmed
16513652
uniprot
proteins
pubmed
16618118
uniprot
proteins
pubmed
16790549
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20305697
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23106386
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23413191
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29222110
uniprot
proteins
pubmed
29789297
uniprot
proteins
pubmed
7797465
uniprot
proteins
sequence_length
416
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
uniprot
proteins