Ets1
entrez
23871
canonical
uniprot
P27577
canonical
ensembl
ENSMUSG00000032035
resolver
ensp
ENSMUSP00000034534
resolver
ensp
ENSMUSP00000051303
resolver
ensp
ENSMUSP00000159086
resolver
ensp
ENSMUSP00000206014
resolver
enst
ENSMUST00000034534
resolver
enst
ENSMUST00000050797
resolver
enst
ENSMUST00000238819
resolver
genesymbol
Ets1
resolver
genesymbol_syn
Ets-1
resolver
uniprot
A0A5F8MPR7
resolver
uniprot
E9PWI8
resolver
uniprot
Q540Q5
resolver
uniprot
Q61403
resolver
uniprot
Q8BVW8
resolver
uniprot
Q8K3Q9
resolver
uniprot_entry
A0A5F8MPR7_MOUSE
resolver
uniprot_entry
E9PWI8_MOUSE
resolver
uniprot_entry
ETS1_MOUSE
resolver
uniprot_entry
Q540Q5_MOUSE
resolver
uniprot_entry
Q8BVW8_MOUSE
resolver
uniprot_entry
Q8K3Q9_MOUSE
resolver
uniprot_sec
Q61403
resolver
activity_regulation
ACTIVITY REGULATION: Autoinhibited by a module composed of four alpha helices (HI-1, HI-2, H4, and H5) that flank the DNA-binding ETS domain, reducing the affinity for DNA (PubMed:15591056, PubMed:15994560). Phosphorylation by CaMK2/CaMKII in response to calcium signaling decreases affinity for DNA (PubMed:15994560). {ECO:0000269|PubMed:15591056, ECO:0000269|PubMed:15994560}.
uniprot
proteins
amino_acid_sequence
MKAAVDLKPTLTIIKTEKVDLELFPSPDMECADVPLLTPSSKEMMSQALKATFSGFTKEQQRLGIPKDPRQWTETHVRDWVMWAVNEFSLKGVDFQKFCMSGAALCALGKECFLELAPDFVGDILWEHLEILQKEDVKPYQVNGANPTYPESCYTSDYFISYGIEHAQCVPPSEFSEPSFITESYQTLHPISSEELLSLKYENDYPSVILQDPLQTDTLQTDYFAIKQEVLTPDNMCLGRASRGKLGGQDSFESVESYDSCDRLTQSWSSQSSFNSLQRVPSYDSFDYEDYPAALPNHKPKGTFKDYVRDRADLNKDKPVIPAAALAGYTGSGPIQLWQFLLELLTDKSCQSFISWTGDGWEFKLSDPDEVARRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRFVCDLQSLLGYTPEELHAMLDVKPDAD
uniprot
proteins
function
FUNCTION: Transcription factor (PubMed:15994560). Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts (By similarity). May control the differentiation, survival and proliferation of lymphoid cells (By similarity). May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion (By similarity). {ECO:0000250|UniProtKB:P14921, ECO:0000269|PubMed:15994560}.
uniprot
proteins
mass_dalton
50202
uniprot
proteins
mutagenesis
MUTAGEN 251; /note="S->A: Decreased phosphorylation, leading to decreased autoinhibition. Strongly decreased phosphorylation, leading to strongly decreased autoinhibition; when associated with 282-A--A-285."; /evidence="ECO:0000269|PubMed:15994560"; MUTAGEN 270; /note="S->A: Does not affect phosphorylation and autoinhibition."; /evidence="ECO:0000269|PubMed:15994560"; MUTAGEN 273; /note="S->A: Does not affect phosphorylation and autoinhibition."; /evidence="ECO:0000269|PubMed:15994560"; MUTAGEN 282..285; /note="SYDS->AYDA: Decreased phosphorylation, leading to decreased autoinhibition. Strongly decreased phosphorylation, leading to strongly decreased autoinhibition; when associated with A-251."; /evidence="ECO:0000269|PubMed:15994560"; MUTAGEN 429; /note="L->A: Reduced autoinhibition."; /evidence="ECO:0000269|PubMed:15994560
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-251, Ser-282 and Ser-285 by CaMK2/CaMKII in response to calcium signaling decreases affinity for DNA: an increasing number of phosphoserines causes DNA-binding to become progressively weaker. {ECO:0000269|PubMed:15994560}.; PTM: Sumoylated on Lys-15 and Lys-227, preferentially with SUMO2; which inhibits transcriptional activity. {ECO:0000269|PubMed:16862185}.; PTM: Ubiquitinated; which induces proteasomal degradation. {ECO:0000269|PubMed:16862185}.
uniprot
proteins
protein_family
ETS family
uniprot
proteins
pubmed
10790365
uniprot
proteins
pubmed
11779502
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15591056
uniprot
proteins
pubmed
15994560
uniprot
proteins
pubmed
16862185
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2163347
uniprot
proteins
pubmed
2204020
uniprot
proteins
pubmed
8598195
uniprot
proteins
pubmed
9566892
uniprot
proteins
pubmed
9770451
uniprot
proteins
sequence_length
440
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P14921}. Cytoplasm {ECO:0000250|UniProtKB:P14921}.
uniprot
proteins