Hnrnpd
entrez
11991
canonical
uniprot
Q60668
canonical
ensembl
ENSMUSG00000000568
resolver
ensp
ENSMUSP00000019128
resolver
ensp
ENSMUSP00000072533
resolver
ensp
ENSMUSP00000108561
resolver
ensp
ENSMUSP00000132735
resolver
ensp
ENSMUSP00000167505
resolver
ensp
ENSMUSP00000167506
resolver
ensp
ENSMUSP00000167507
resolver
ensp
ENSMUSP00000167508
resolver
enst
ENSMUST00000072750
resolver
enst
ENSMUST00000112939
resolver
genesymbol
Hnrnpd
resolver
genesymbol_syn
Auf1
resolver
genesymbol_syn
Hnrpd
resolver
uniprot
G3X9W0
resolver
uniprot
G5E8G0
resolver
uniprot
Q60667
resolver
uniprot
Q80ZJ0
resolver
uniprot
Q91X94
resolver
uniprot_entry
G3X9W0_MOUSE
resolver
uniprot_entry
G5E8G0_MOUSE
resolver
uniprot_entry
HNRPD_MOUSE
resolver
uniprot_sec
Q60667
resolver
uniprot_sec
Q80ZJ0
resolver
uniprot_sec
Q91X94
resolver
amino_acid_sequence
MSEEQFGGDGAAAAATAAVGGSAGEQEGAMVAAAAQGPAAAAGSGSGGGGSAAGGTEGGSAEAEGAKIDASKNEEDEGHSNSSPRHTEAAAAQREEWKMFIGGLSWDTTKKDLKDYFSKFGEVVDCTLKLDPITGRSRGFGFVLFKESESVDKVMDQKEHKLNGKVIDPKRAKAMKTKEPVKKIFVGGLSPDTPEEKIREYFGGFGEVESIELPMDNKTNKRRGFCFITFKEEEPVKKIMEKKYHNVGLSKCEIKVAMSKEQYQQQQQWGSRGGFAGRARGRGGGPSQNWNQGYSNYWNQGYGNYGYNSQGYGGYGGYDYTGYNNYYGYGDYSNQQSGYGKVSRRGGHQNSYKPY
uniprot
proteins
function
FUNCTION: Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Also binds to double- and single-stranded DNA sequences in a specific manner and functions a transcription factor. Each of the RNA-binding domains specifically can bind solely to a single-stranded non-monotonous 5'-UUAG-3' sequence and also weaker to the single-stranded 5'-TTAGGG-3' telomeric DNA repeat. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats. Binding of RRM1 to DNA inhibits the formation of DNA quadruplex structure which may play a role in telomere elongation. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. May play a role in the regulation of the rhythmic expression of circadian clock core genes. Directly binds to the 3'UTR of CRY1 mRNA and induces CRY1 rhythmic translation. May also be involved in the regulation of PER2 translation. {ECO:0000250|UniProtKB:Q14103}.
uniprot
proteins
mass_dalton
38354
uniprot
proteins
post_translational_modification
PTM: Methylated by PRMT1, in an insulin-dependent manner. The PRMT1-mediated methylation regulates its phosphorylation (By similarity). {ECO:0000250|UniProtKB:Q14103}.; PTM: Arg-345 is dimethylated, probably to asymmetric dimethylarginine. {ECO:0000250|UniProtKB:Q14103}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
7959009
uniprot
proteins
sequence_length
355
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q14103}. Cytoplasm {ECO:0000250|UniProtKB:Q14103}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Cytoplasmic localization oscillates diurnally. {ECO:0000250|UniProtKB:Q14103}.
uniprot
proteins