Q8VHH5
uniprot
Q8VHH5
canonical
activity_regulation
ACTIVITY REGULATION: GTPase activity is stimulated by oxidative stress. {ECO:0000269|PubMed:16461359}.
uniprot
proteins
amino_acid_sequence
MNFQAGGGQSPQQQQSLAAPGGGGAAAQQLVCGGQFGGAGPGAGGGGPSQQLAGGPPQQFALSNSAAIRAEIQRFESVHPNIYAIYDLIERIEDLALQNQIREHVISIEDSFVNSQEWTLSRSVPELKVGIVGNLSSGKSALVHRYLTGTYVQEESPEGGRFKKEIVVDGQSYLLLIRDEGGPPELQFAAWVDAVVFVFSLEDEISFQTVYNYFLRLCSFRNASEVPMVLVGTQDAISAANPRVIDDSRARKLSTDLKRCTYYETCATYGLNVERVFQDVAQKVVALRKKQQLAIGPCKSLPNSPSHSAVSAASIPAVHINQATNGGSSAFSDYSSSVPSTPSISQRELRIETIAASSTPTPIRKQSKRRSNIFTSRKGADLDREKKAAECRVDSIGSGRAIPIKQGILLKRSGKSLNKEWKKKYVTLCDNGLLTYHPSLHDYMQNIHGKEIDLLRTTVKVPGKRLPRATPTTAPGTSPRANGLAMERSNTQLGGATGAPHSASSTSLHSERPHSSAWAGSRPGPEGLHQRSCSVSSTDQWSEAAALPASMQHPASGPAESLSSSPKLEPPPSPHSNRKKHRGKKSTGTPRPDGPSSAAEEAEESFEFVVVSLTGQTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQNTALAVQAVRTVRGNSLCIDCEAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAMGNALANSVWEGALDGYSKPGPEACREEKERWIRAKYEQKLFLAPLPSSDVPLGQQLLRAVVEDDLRLLVMLLAHGSKEEVNETYGDGDGRTALHLSSAMANVVFTQLLIWYGVDVRSRDARGLTPLAYARRAGSQECADILIQHGCPGEGCGLAPTPNREPANGTNPSAELHRSPSIL
uniprot
proteins
function
FUNCTION: GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway. {ECO:0000269|PubMed:16461359, ECO:0000305}.
uniprot
proteins
mass_dalton
97965
uniprot
proteins
mutagenesis
MUTAGEN 140; /note="S->N: Abolishes interaction with PML."; /evidence="ECO:0000269|PubMed:16461359"; MUTAGEN 368..369; /note="KR->EE: Abolishes translocation to PML nuclear bodies upon oxidative stress."; /evidence="ECO:0000269|PubMed:16461359
uniprot
proteins
protein_family
Centaurin gamma-like family
uniprot
proteins
pubmed
15381706
uniprot
proteins
pubmed
16461359
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
910
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Note=Upon oxidative stress, translocates to PML nuclear bodies. {ECO:0000250}.
uniprot
proteins