Adgrf1
entrez
77596
canonical
uniprot
Q8VEC3
canonical
ensembl
ENSMUSG00000041293
resolver
ensp
ENSMUSP00000049380
resolver
enst
ENSMUST00000047399
resolver
genesymbol
Adgrf1
resolver
genesymbol_syn
Gpr110
resolver
uniprot
B0V2Q5
resolver
uniprot
Q8BMV8
resolver
uniprot_entry
AGRF1_MOUSE
resolver
uniprot_sec
B0V2Q5
resolver
uniprot_sec
Q8BMV8
resolver
activity_regulation
ACTIVITY REGULATION: Forms a heterodimer of 2 chains generated by proteolytic processing that remain associated through non-covalent interactions mediated by the GAIN-B domain (By similarity). In the inactivated receptor, the Stachel sequence (also named stalk) is embedded in the GAIN-B domain, where it adopts a beta-strand conformation. On activation, the Stachel moves into the 7 transmembrane region and adopts a twisted hook-shaped configuration that forms contacts within the receptor, leading to coupling of a G-alpha protein, which activates signaling. The cleaved GAIN-B and N-terminal domains can then dissociate from the rest of the receptor (By similarity). {ECO:0000250|UniProtKB:Q5T601, ECO:0000255|PROSITE-ProRule:PRU00098}.
uniprot
proteins
amino_acid_sequence
MRIGLLWLVPLFTLTEGTDGFLQQKNDGRRTKEIVSMVEERHPVHEYEVLLQVTYRDPEEKRELKRFLKLLKSPSPSLRGPSKIIRVKATTYCRSRKGFLECACEDSYTWFPPSCLDPQNCCLHTTGPVPSCNCSLRGLRQSINFCERAKVWGTFEIDEKFPEDLWNSSSDVYAHYTVGIENQLKEAYRRVHGFESVRVTQFRKGSIVVGYEVTGSTSPPELLFAIEQEAEKAQEALRRQFPVKYGSFRVFGKAPCNSISFGFGSENDEYTVPCSSGFTGSMTVRCQSSGWQITRESCVLSQLEELKKELRMIAGKITEAGVASLVQNLSTILLQSPSTTVGNLGSVVSLLSNISSLSLANSLTVSNLTLMNVINIADHILDSASITNWTILLQDAKDASSQLLKTLESISSLIPSMALPLNFSGKFIDWKGTPVTQIQSTRGYNYQMEMRQNASLPIRGHVFIEPDQFQKSHPKTIISMASLTFGDILPITQRGNAWVNGPVISTLIQNYSISEIFLNFSKIKGNLTQPRCVFWDFSQLQWSNAGCQLVNETLDTVLCRCSHLTSFSMLMSPFVPSSVVPVVKWITYIGLSISIASLILCLIIESLFWKQTKRSQTSYTRNICLVNIAVSLLIADVWFIIAATVDPSVSPSGVCVAAVFFTHFFYLAVFFWMLVLGILLAYRIILVFHHMALTTMMAIGFCLGYGCPLLISIITLAVTQPSNSYKRNDVCWLNWSDKSKPLLAFVVPALTIVAVNLVVVLLVLRKLWRPAVGERLNQDDKATAIRMGKSLLVLTPLLGLTWGFGIGTMANSHNLAWHVLFALLNAFQGFFIFCFGILLDTKLRQLLSNKLTTLSSWKQTSKRNASDTVTQPKCLRTFNILQHRGMYALSHTGDSSSDITLTQFLSTE
uniprot
proteins
function
FUNCTION: Adhesion G protein-coupled receptor (aGPCR) for N-docosahexaenoylethanolamine (synaptamide), an omega-3 fatty acid lipid highly enriched in the brain (PubMed:27759003). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:27759003). ADGRF1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (PubMed:27759003). Also able to couple to G(q), G(i) and G(12)/G(13) G proteins; additional evidence is however required to confirm this result in vivo (By similarity). Involved in the development of neurons and cognitive function (PubMed:27759003). In liver, involved in fat accumulation (PubMed:37580962). {ECO:0000250|UniProtKB:Q5T601, ECO:0000269|PubMed:27759003, ECO:0000269|PubMed:37580962}.
uniprot
proteins
mass_dalton
101469
uniprot
proteins
post_translational_modification
PTM: Autoproteolytically processed at the GPS region of the GAIN-B domain; this cleavage modulates receptor activity. {ECO:0000250|UniProtKB:Q5T601}.
uniprot
proteins
protein_family
Adhesion G protein-coupled receptor (ADGR) subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22837050
uniprot
proteins
pubmed
27759003
uniprot
proteins
pubmed
37580962
uniprot
proteins
sequence_length
908
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5T601}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q5T601}.
uniprot
proteins
transmembrane_region
TRANSMEM 589..609; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 623..643; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 659..679; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 698..718; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 743..763; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 790..810; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 819..839; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins