Lztr1
entrez
66863
canonical
uniprot
Q9CQ33
canonical
ensembl
ENSMUSG00000022761
resolver
ensp
ENSMUSP00000023444
resolver
ensp
ENSMUSP00000156018
resolver
ensp
ENSMUSP00000286965
resolver
genesymbol
Lztr1
resolver
genesymbol_syn
Tcfl2
resolver
uniprot_entry
LZTR1_MOUSE
resolver
amino_acid_sequence
MAGSGGPIGSGALTGGVRSKVAPSVDFDHSCSDSVEYLTLNFGPFETVHRWRRLPPCDEFVGARRSKHTVVAYKDAIYVFGGDNGKTMLNDLLRFDVKDCSWCRAFTTGTPPAPRYHHSAVVYGSSMFVFGGYTGDIYSNSNLKNKNDLFEYKFATGQWTEWKIEGRLPVARSAHGATVYSDKLWIFAGYDGNARLNDMWTIGLQDRELTCWEEVAQSGEIPPSCCNFPVAVCRDKMFVFSGQSGAKITNNLFQFEFKDKTWTRIPTEHLLRGSPPPPQRRYGHTMVAFDRHLYVFGGAADNTLPNELHCYDVDFQTWEVVQPSSDSEVGGAEMPERASSSEDASTLTSEERSSFKKSRDVFGLDFGTTSAKQPVHLASELPSGRLFHAAAVISDAMYIFGGTVDNNIRSGEMYRFQFSCYPKCTLHEDYGRLWEGRQFCDVEFVLGEKEECVQGHVAIVTARSRWLRRKIVQAQEWLAQKLEEDGALAPKEAPGPAVGRARPPLLRVAIREAEARPFEVLMQFLYTDKIKYPRKGHVEDVLLIMDVYKLALSFQLCRLEQLCRQYIEASVDLQNVLVVCESAARLQLGQLKEHCLNFIVKESHFNQVIMMKEFERLSSPLIVEIVRRKQQPPPRTPSDQPVDIGTSLIQDMKAYLEGAGSEFCDITLLLDGQPRPAHKAILAARSSYFEAMFRSFMPEDGQVNISIGEMVPSRQAFESMLRYIYYGEVNMPPEDSLYLFAAPYYYGFYNNRLQAYCKQNLEMNVTVQNVLQILEAADKTQALDMKRHCLHIIVHQFTKVSKLPTLRLLSQQLLLDIIDSLASHISDKQCAELGADI
uniprot
proteins
function
FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras GTPases (M-Ras/MRAS, K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS) and Ras-like protein RIT1 (PubMed:30442762). Acts as a negative regulator of RAS-MAPK signaling by controlling Ras levels and decreasing Ras association with membranes (PubMed:30442762). {ECO:0000269|PubMed:30442762}.
uniprot
proteins
mass_dalton
94476
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q8N653}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine upon induction of apoptosis, leading to its degradation by the proteasome. {ECO:0000250|UniProtKB:Q8N653}.
uniprot
proteins
protein_family
LZTR1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16356934
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30442762
uniprot
proteins
sequence_length
837
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250|UniProtKB:Q8N653}. Recycling endosome {ECO:0000250|UniProtKB:Q8N653}. Golgi apparatus {ECO:0000250|UniProtKB:Q8N653}.
uniprot
proteins