Gnpda1
entrez
26384
canonical
uniprot
O88958
canonical
ensembl
ENSMUSG00000052102
resolver
ensp
ENSMUSP00000069081
resolver
enst
ENSMUST00000063814
resolver
genesymbol
Gnpda1
resolver
genesymbol_syn
Gnpi
resolver
uniprot
Q3TKA0
resolver
uniprot
Q91WJ4
resolver
uniprot
Q9R188
resolver
uniprot_entry
GNPI1_MOUSE
resolver
uniprot_entry
Q3TKA0_MOUSE
resolver
uniprot_sec
Q91WJ4
resolver
uniprot_sec
Q9R188
resolver
activity_regulation
ACTIVITY REGULATION: Allosterically activated by N-acetylglucosamine-6-phosphate (GlcNAc6P). {ECO:0000250|UniProtKB:P46926}.
uniprot
proteins
amino_acid_sequence
MKLIILEHYSQASEWAAKYIRNRIIQFNPGPDKYFTLGLPTGSTPLGCYQKLIEYYKNGDLSFQYVKTFNMDEYVGLPRDHPESYHSFMWNNFFKHIDIHPENTHILDGNAADLQAECDAFEEKIQAAGGIELFVGGIGPDGHIAFNEPGSSLVSRTRVKTLAMDTILANARFFDGDLAKVPTMALTVGVGTVMDAKEVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTVFVCDEDATLELKVKTVKYFKGLMLVHNKLVDPLYSIKEKEIQKSQSAKKPYSD
uniprot
proteins
ec_number
3.5.99.6
uniprot
proteins
function
FUNCTION: Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis (By similarity). Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling (By similarity). Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity). {ECO:0000250|UniProtKB:P46926, ECO:0000250|UniProtKB:Q64422}.
uniprot
proteins
mass_dalton
32549
uniprot
proteins
pathway_participation
PATHWAY: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1. {ECO:0000250|UniProtKB:P46926}.
uniprot
proteins
protein_family
Glucosamine/galactosamine-6-phosphate isomerase family
uniprot
proteins
pubmed
10481053
uniprot
proteins
pubmed
10862010
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
289
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10481053}.
uniprot
proteins