Parl
entrez
287979
canonical
uniprot
Q3B8P0
canonical
ensembl
ENSRNOG00000023271
resolver
ensp
ENSRNOP00000093736
resolver
ensp
ENSRNOP00000108723
resolver
genesymbol
Parl
resolver
genesymbol_syn
Psarl
resolver
uniprot
B0BMU4
resolver
uniprot
Q5I0L2
resolver
uniprot_entry
B0BMU4_RAT
resolver
uniprot_entry
PARL_RAT
resolver
uniprot_sec
Q5I0L2
resolver
amino_acid_sequence
MALYSWVQRGWRCGQTWAPLLGGGYRELSATQARQLLGRRFNLLLQQKCGFRKAPRKVEPRRSDTGSSGEAYKRSALIPPLEETVFYPSPYPVRTLLKPFFFTVGFTGCAFGSAAIWQYESLKSRVQSYFDGIKADWLDSIRPQKEGNLRKEINKWWNSLSDGQRTVTGIIAANALVFCLWRVPSLHRTMIRYFTSNPASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSTSIVNILGQEQFVAVYLSAGVISNFVSYVCKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIFLPVFTFTAGNALKAIIAMDTAGMILGWKFFDHAAHLGGALFGIWYITYGHELIWKNREPLVKIWHEIRTNGPKKGGGSK
uniprot
proteins
ec_number
3.4.21.105
uniprot
proteins
function
FUNCTION: Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP). Promotes cleavage of serine/threonine-protein phosphatase PGAM5 in damaged mitochondria in response to loss of mitochondrial membrane potential. Mediates differential cleavage of PINK1 and PGAM5 depending on the health status of mitochondria, disassociating from PINK1 and associating with PGAM5 in response to mitochondrial membrane potential loss. Required for processing of CLPB into a form with higher protein disaggregase activity by removing an autoinhibitory N-terminal peptide. Promotes processing of DIABLO/SMAC in the mitochondrion which is required for DIABLO apoptotic activity (By similarity). Mediates STARD7 processing which regulates STARD7 location between mitochondria and cytosol. Also required for cleavage of TTC19. Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (By similarity). {ECO:0000250|UniProtKB:Q5XJY4, ECO:0000250|UniProtKB:Q9H300}.
uniprot
proteins
mass_dalton
42126
uniprot
proteins
post_translational_modification
PTM: P-beta is proteolytically processed (beta-cleavage) in a PARL-dependent manner. {ECO:0000250|UniProtKB:Q9H300}.
uniprot
proteins
protein_family
Peptidase S54 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
377
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9H300}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9H300}.; SUBCELLULAR LOCATION: [P-beta]: Nucleus {ECO:0000250|UniProtKB:Q9H300}. Note=Translocated into the nucleus by an unknown mechanism. {ECO:0000250|UniProtKB:Q9H300}.
uniprot
proteins
transmembrane_region
TRANSMEM 96..116; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 166..186; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 215..235; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 243..263; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 269..289; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 294..314; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 332..352; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins