Gpbar1
entrez
338443
canonical
uniprot
Q80T02
canonical
ensembl
ENSRNOG00000087111
resolver
ensembl
ENSRNOG00055009755
resolver
ensembl
ENSRNOG00060007635
resolver
ensembl
ENSRNOG00065008699
resolver
ensp
ENSRNOP00000110717
resolver
ensp
ENSRNOP00055013307
resolver
ensp
ENSRNOP00060009536
resolver
ensp
ENSRNOP00065010284
resolver
enst
ENSRNOT00000134597
resolver
enst
ENSRNOT00055016511
resolver
enst
ENSRNOT00060012586
resolver
enst
ENSRNOT00065013835
resolver
genesymbol
Gpbar1
resolver
genesymbol_syn
Tgr5
resolver
uniprot
U5JAP5
resolver
uniprot_entry
GPBAR_RAT
resolver
uniprot_entry
U5JAP5_RAT
resolver
amino_acid_sequence
MMSHNTTELSAIPRGVQELSLVLASLIVIANLLLALGIVLDRHLRSPPAGCFFLSLLLAGLLTGLALPTLPGLWNRSHQGYWSCLLLHLAPNFCFLSLLANLLLVHGERYMAVLQPLRPHGSVRLALFLTWISSLLFASLPALGWNHWSPGANCSSQAIFPAPYLYLEVYGLLLPAVGATALLSVRVLATAHHQLREIRRLERAVCRDAPSTLARALTWRQARAQAGATLLFLLCWGPYVATLLLSVLAYERRPPLGPVTLLSLISLGSASAAVVPVAMGLGDQRYTAPWRTAAQRWLQVLRGRPKRANPGPSTAYHSSSQCSTDLDLN
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for bile acid. Bile acid-binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. GPBAR1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (By similarity). Activated by bile acids, such as lithocholate, deoxycholate, chenodeoxycholate and cholate, in descending order. Apart from their role in lipid dietary absorption and cholesterol catabolism, bile acids act as an important signaling molecule, involved in processes, such as energy expenditure or tissue inflammation (By similarity). GPBAR1-mediated signaling promotes energy expenditure and adiposity reduction in brown adipose tissue by activating adenylate cyclase, leading to DIO2 activation. Involved in bile acid promoted GLP-1 secretion (By similarity). {ECO:0000250|UniProtKB:Q80SS6, ECO:0000250|UniProtKB:Q8TDU6}.
uniprot
proteins
mass_dalton
35791
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12419312
uniprot
proteins
pubmed
12524422
uniprot
proteins
sequence_length
329
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8TDU6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TDU6}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..40; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q8TDU6"; TRANSMEM 50..71; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q8TDU6"; TRANSMEM 85..107; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q8TDU6"; TRANSMEM 123..143; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q8TDU6"; TRANSMEM 160..185; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q8TDU6"; TRANSMEM 225..248; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q8TDU6"; TRANSMEM 261..282; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q8TDU6
uniprot
proteins