Dsg1c
entrez
211924
canonical
uniprot
Q7TSF0
canonical
ensembl
ENSMUSG00000034774
resolver
ensp
ENSMUSP00000054799
resolver
genesymbol
Dsg1c
resolver
genesymbol_syn
Dsg6
resolver
uniprot
Q7TQ61
resolver
uniprot_entry
DSG1C_MOUSE
resolver
uniprot_sec
Q7TQ61
resolver
amino_acid_sequence
MDWHSFRIAALLLTSLVVLEVNSEFQIQVRDHNAKNGTIKWHSIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQPVTYRISGVGIDQPPYGIFIINQKTGEINITSIVDREVTPFFIIYCRALNAQGQDLENPLELRVRVMDINDNPPVFSMTTFLGQIEENSNANTLVMKLNATDADEPNNLNSMIAFKIIRQEPSDSPMFTINRKTGEIRTMNNFLDREQYSQYSLVVRGSDRDGGADGMSAESECSITILDVNDNIPYLEQSSYDITIEENTLHSQLLQIRVIDLDEEFSDNWKAIIFFISGNEGNWFEIEMNERTNVGTLKVVKPLDYEAVKNLQLCIGVRNVAEFHQSIISQYRLTVTLITVTVLNVVKGCVFQPGSKTFIVDSRMEANHTVGEFLATDCETGQATNKFKNVRYRYVMGNNPENLLVVDSGIITLRNRVTMEQYERLNKRYEGTVLSIHDSLQRTCTGTIIMVLCGFWTTTEHPTTSTEKPVTLSITPNVDNVHFGPAGIGLLIMGFLVLGLVPFLLISCDCGGAPGGGAGFEPVPECSDGAIHTWAVEGPQPGGITTICVPQMPPGNANVIEYIDNSGVYTNEYCGREMQDLGGGERTTGFELMDGVKTSAAPEICQEYSGTLRRNSMRECRDGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIEDLDESFLDTLGPKFKKLADISLGKEIDSYPDPDPSWPPQSTEPICPQHMEQLASGHPSISPHFGKTTVISENAYPSGPGVQHPMLIPDPLGYGNITVRESYTTSGTLKPSVHFHDNQQASNVVVTERVVGPISGADLHGMLEIPALRDGTNVIVTERVIAPGSSLPNSLTIPNPRETSNVVVTERVIQPTSGMIGNLSIPP
uniprot
proteins
function
FUNCTION: A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Mediates the interaction between the desmosome and COP9 signalosome complex (CSN) protein complex (By similarity). As a result of this interaction, promotes keratinocyte differentiation via deneddylation of EGFR resulting in a reduction in EGFR protein stabilization and translocation away from the cell membrane (By similarity). Critical for epidermal integrity and barrier function of the skin (PubMed:30660666). May mediate the inflammatory response in the epidermis (PubMed:34905516). Required for esophageal epithelial barrier integrity and correct intercellular spacing in differentiated esophageal epithelium (By similarity). Required for recovery of epidermal architecture and correct expression of differentiation markers following UVB exposure (By similarity). May also be required for OCLN involvement in tight junctions (PubMed:30660666). {ECO:0000250|UniProtKB:Q02413, ECO:0000250|UniProtKB:Q7TSF1, ECO:0000269|PubMed:30660666, ECO:0000269|PubMed:34905516}.
uniprot
proteins
mass_dalton
100516
uniprot
proteins
pubmed
12631243
uniprot
proteins
pubmed
12787123
uniprot
proteins
pubmed
16170054
uniprot
proteins
pubmed
24220297
uniprot
proteins
pubmed
30660666
uniprot
proteins
pubmed
34905516
uniprot
proteins
sequence_length
911
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q7TSF1}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q7TSF1}. Cell junction, desmosome {ECO:0000250|UniProtKB:Q7TSF1}. Cytoplasm {ECO:0000250|UniProtKB:Q02413}. Nucleus {ECO:0000250|UniProtKB:Q02413}.
uniprot
proteins
transmembrane_region
TRANSMEM 520..540; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins