RANBP3
entrez
8498
canonical
uniprot
Q9H6Z4
canonical
ensembl
ENSG00000031823
resolver
ensp
ENSP00000034275
resolver
ensp
ENSP00000341483
resolver
ensp
ENSP00000404837
resolver
ensp
ENSP00000465085
resolver
ensp
ENSP00000522176
resolver
ensp
ENSP00000744647
resolver
enst
ENST00000591092
resolver
genesymbol
RANBP3
resolver
hgnc
HGNC:9850
resolver
uniprot
B2RAT8
resolver
uniprot
B7Z7F3
resolver
uniprot
K7EJA2
resolver
uniprot
O60405
resolver
uniprot
O75759
resolver
uniprot
O75760
resolver
uniprot
Q53GE1
resolver
uniprot
Q9BT47
resolver
uniprot
Q9UG74
resolver
uniprot_entry
B7Z7F3_HUMAN
resolver
uniprot_entry
K7EJA2_HUMAN
resolver
uniprot_entry
Q53GE1_HUMAN
resolver
uniprot_entry
RANB3_HUMAN
resolver
uniprot_sec
B2RAT8
resolver
uniprot_sec
O60405
resolver
uniprot_sec
O75759
resolver
uniprot_sec
O75760
resolver
uniprot_sec
Q9BT47
resolver
uniprot_sec
Q9UG74
resolver
amino_acid_sequence
MADLANEEKPAIAPPVFVFQKDKGQKSPAEQKNLSDSGEEPRGEAEAPHHGTGHPESAGEHALEPPAPAGASASTPPPPAPEAQLPPFPRELAGRSAGGSSPEGGEDSDREDGNYCPPVKRERTSSLTQFPPSQSEERSSGFRLKPPTLIHGQAPSAGLPSQKPKEQQRSVLRPAVLQAPQPKALSQTVPSSGTNGVSLPADCTGAVPAASPDTAAWRSPSEAADEVCALEEKEPQKNESSNASEEEACEKKDPATQQAFVFGQNLRDRVKLINESVDEADMENAGHPSADTPTATNYFLQYISSSLENSTNSADASSNKFVFGQNMSERVLSPPKLNEVSSDANRENAAAESGSESSSQEATPEKESLAESAAAYTKATARKCLLEKVEVITGEEAESNVLQMQCKLFVFDKTSQSWVERGRGLLRLNDMASTDDGTLQSRLVMRTQGSLRLILNTKLWAQMQIDKASEKSIRITAMDTEDQGVKVFLISASSKDTGQLYAALHHRILALRSRVEQEQEAKMPAPEPGAAPSNEEDDSDDDDVLAPSGATAAGAGDEGDGQTTGST
uniprot
proteins
function
FUNCTION: Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. {ECO:0000269|PubMed:11425870, ECO:0000269|PubMed:11571268, ECO:0000269|PubMed:11932251, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:9637251}.
uniprot
proteins
mass_dalton
60210
uniprot
proteins
mutagenesis
MUTAGEN 110; /note="R->A: Does not affect nuclear import."; /evidence="ECO:0000269|PubMed:10567565"; MUTAGEN 117..118; /note="PP->AA: Does not affect nuclear import."; /evidence="ECO:0000269|PubMed:10567565"; MUTAGEN 117; /note="P->A: Does not affect nuclear import."; /evidence="ECO:0000269|PubMed:10567565"; MUTAGEN 118; /note="P->A: Does not affect nuclear import."; /evidence="ECO:0000269|PubMed:10567565"; MUTAGEN 120; /note="K->A: Impaired nuclear import."; /evidence="ECO:0000269|PubMed:10567565"; MUTAGEN 121; /note="R->A: Abolished nuclear import."; /evidence="ECO:0000269|PubMed:10567565"; MUTAGEN 126; /note="S->A: Abolished translocation into the nucleus."; /evidence="ECO:0000269|PubMed:18280241"; MUTAGEN 221; /note="S->A: Does not affect translocation into the nucleus."; /evidence="ECO:0000269|PubMed:18280241
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-126 promotes its import into the nucleus. {ECO:0000269|PubMed:18280241}.
uniprot
proteins
pubmed
10567565
uniprot
proteins
pubmed
11425870
uniprot
proteins
pubmed
11571268
uniprot
proteins
pubmed
11932251
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18280241
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19289081
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28760339
uniprot
proteins
pubmed
9637251
uniprot
proteins
sequence_length
567
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10567565, ECO:0000269|PubMed:18280241, ECO:0000269|PubMed:19289081}. Nucleus {ECO:0000269|PubMed:10567565, ECO:0000269|PubMed:18280241, ECO:0000269|PubMed:19289081, ECO:0000269|PubMed:28760339}. Note=Nuclear import is promoted by phosphorylation at Ser-126 and is dependent on KPNA4. {ECO:0000269|PubMed:10567565, ECO:0000269|PubMed:18280241, ECO:0000269|PubMed:28760339}.
uniprot
proteins