Ptprd
entrez
19266
canonical
uniprot
Q64487
canonical
ensembl
ENSMUSG00000028399
resolver
ensp
ENSMUSP00000058466
resolver
ensp
ENSMUSP00000102910
resolver
ensp
ENSMUSP00000133468
resolver
ensp
ENSMUSP00000133973
resolver
ensp
ENSMUSP00000134229
resolver
ensp
ENSMUSP00000245283
resolver
ensp
ENSMUSP00000245285
resolver
ensp
ENSMUSP00000245287
resolver
ensp
ENSMUSP00000245298
resolver
ensp
ENSMUSP00000245299
resolver
ensp
ENSMUSP00000245301
resolver
enst
ENSMUST00000173376
resolver
genesymbol
Ptprd
resolver
uniprot
B9EJA3
resolver
uniprot
G3UWY1
resolver
uniprot
G3X9S7
resolver
uniprot
Q64486
resolver
uniprot
Q64488
resolver
uniprot
Q64495
resolver
uniprot
Q8VBV0
resolver
uniprot_entry
B9EJA3_MOUSE
resolver
uniprot_entry
G3UWY1_MOUSE
resolver
uniprot_entry
PTPRD_MOUSE
resolver
uniprot_sec
G3X9S7
resolver
uniprot_sec
Q64486
resolver
uniprot_sec
Q64488
resolver
uniprot_sec
Q64495
resolver
uniprot_sec
Q8VBV0
resolver
amino_acid_sequence
MVPVARPLSLLLTFFLCACAETPPRFTRTPVDQTGVSGGVASFICQATGDPRPKIVWNKKGKKVSNQRFEVIEFDDGSGSVLRIQPLRTPRDEAIYECVASNNVGEISVSTRLTVLREDQIPRGFPTIDMGPQLKVVERTRTATMLCAASGNPDPEITWFKDFLPVDTSNNNGRIKQLRSESIGGTPIRGALQIEQSEESDQGKYECVATNSAGTRYSAPANLYVRELREVRRVPPRFSIPPTNHEIMPGGSVNITCVAVGSPMPYVKWMLGAEDLTPEDDMPIGRNVLELNDVRQSANYTCVAMSTLGVIEAIAQITVKALPKPPGTPVVTESTATSITLTWDSGNPEPVSYYIIQHKPKNSEEPYKEIDGIATTRYSVAGLSPYSDYEFRVVAVNNIGRGPASEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEEPNGQIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTIASYELVYRDGDQGEEQRITIEPGTSYRLQGLKPNSLYYFRLSARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSLKYAAVDGEDFKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTDEDVPSGPPRKVEVEAVNATAVKVSWRSPVPNKQHGQIRGYQVHYVKMENGEPKGQPMLKDVMLADAQWEFDDTTEHDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPGKPRLVINHTQMNTALIQWHPPVDTFGPLQGYRLKFGRKDMEPLTTLEFSEKEDHFTATDIHKGASYVFRLSARNKVGFGEEMVKEISVPEEIPTGFPQNLHSEGTTSTSVQLSWQPPVLAERNGVITKYTLLYRDINVPLLPMEHLIVPADTSMTLTGLKSDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSVLLSWEIPENYNSAMPFKILYDDGKMVEEVDGRATQKLIVNLKPEKSYSFVLTNRGNSAGGLQHRVTAKTAPDVLRTKPAFIGKTNLDGMITVQLPDVPANENIKGYYIIIVPLKKSRGKFIKPWESPDEMELDELLKEISRKRRSIRYGREVELKPYIAAHFDVLPTEFTLGDDKHYGGFTNKQLQSGQEYVFFVLAVMDHAESKMYATSPYSDPVVSMDLDPQPITDEEEGLIWVVGPVLAVVFIICIVIAILLYKRKRAESESRKSSLPNSKEVPSHHPTDPVELRRLNFQTPGMASHPPIPILELADHIERLKANDNLKFSQEYESIDPGQQFTWEHSNLEVNKPKNRYANVIAYDHSRVLLSAIEGIPGSDYVNANYIDGYRKQNAYIATQGSLPETFGDFWRMIWEQRSATVVMMTKLEERSRVKCDQYWPSRGTETHGLVQVTLLDTVELATYCVRTFALYKNGSSEKREVRQFQFTAWPDHGVPEHPTPFLAFLRRVKTCNPPDAGPMVVHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYGHVTLMRAQRNYMVQTEDQYIFIHDALLEAVTCGNTEVPARNLYAYIQKLTQIETGENVTGMELEFKRLASSKAHTSRFISANLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAETTEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKMLRTQRPAMVQTEDQYQFCYRAALEYLGSFDHYAT
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Can bidirectionally induce pre- and post-synaptic differentiation of neurons by mediating interaction with IL1RAP and IL1RAPL1 trans-synaptically (PubMed:25908590). Involved in pre-synaptic differentiation through interaction with SLITRK2 (PubMed:25989451). {ECO:0000269|PubMed:25908590, ECO:0000269|PubMed:25989451}.
uniprot
proteins
mass_dalton
214410
uniprot
proteins
mutagenesis
MUTAGEN 68; /note="R->A: Reduces affinity with IL1RAPL1. Reduces the synaptogenic activity to ~7%."; /evidence="ECO:0000269|PubMed:25908590"; MUTAGEN 189; /note="R->A: Decreases affinity for interaction with IL1RAPL1."; /evidence="ECO:0000269|PubMed:25908590"; MUTAGEN 229; /note="R->E: Abolishes interaction with SLITRK2."; /evidence="ECO:0000269|PubMed:25989451"; MUTAGEN 266; /note="Y->A: No effect on interaction with SLITRK2. Decreases the affinity for IL1RAPL1. Abolishes interaction with IL1RAP."; /evidence="ECO:0000269|PubMed:25908590, ECO:0000269|PubMed:25989451"; MUTAGEN 279; /note="E->A: Decreases affinity for IL1RAP."; /evidence="ECO:0000269|PubMed:25908590
uniprot
proteins
post_translational_modification
PTM: A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
protein_family
Receptor class 2A subfamily
uniprot
proteins
pubmed
11978849
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21940441
uniprot
proteins
pubmed
25908590
uniprot
proteins
pubmed
25989451
uniprot
proteins
pubmed
7832766
uniprot
proteins
pubmed
8355697
uniprot
proteins
sequence_length
1912
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 1267..1287; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins