Spag8
entrez
433700
canonical
uniprot
Q3V0Q6
canonical
ensembl
ENSMUSG00000066196
resolver
ensp
ENSMUSP00000081696
resolver
ensp
ENSMUSP00000103502
resolver
genesymbol
Spag8
resolver
uniprot
B9EKF1
resolver
uniprot
Q5UAV3
resolver
uniprot_entry
SPAG8_MOUSE
resolver
uniprot_sec
B9EKF1
resolver
uniprot_sec
Q5UAV3
resolver
amino_acid_sequence
METTESTEGSLSRSCDVQPSSERLDTPSEPVPSSSSSPRSTAPAEAPAQYSVLTEPSSDSLYGAPCPPAHHRGHGFGFQPFYVSCIPQDPCNMADLSSRADPTSSYPCHSSVHGSGSGTCGLGQSSEPSQGSGPTSGPAPASVPSLVSGPDSASGPDSSASGPALASGPGPADPGQGPKFSTCIPQGYRCIPVDLAPDYNAWCQHLHWKPQRSWEPLQVSEPGVRGPYKPPEPGALGPCEPCEPCEPPEAESEETLCKARPRGQCLLYNWEEERATNQLDQIPPLQDGSESYFFRHGHQGLLTTQPQSPMSSSTTQRDSYQLPRHICQPLRGKREAMLEMLLRHQICKEVQAEQEPARKLFETESVTHHDYRVELVRAAPPASTKPHDYRQEQPETFWIQRAARLPGVSDIRTLDTPFRKNCSFSTPVPLSLGQPLPYELESGPHQVGVISSLACQGGGQGCGRTKTTPI
uniprot
proteins
function
FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:37295417, PubMed:37865089, PubMed:37989994). Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau (PubMed:20488182). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (PubMed:17187156). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis (By similarity). May play a role in fertility and microtubule formation through interaction with RANBP9 (By similarity). {ECO:0000250|UniProtKB:Q99932, ECO:0000269|PubMed:17187156, ECO:0000269|PubMed:20488182, ECO:0000269|PubMed:37295417, ECO:0000269|PubMed:37865089, ECO:0000269|PubMed:37989994}.
uniprot
proteins
mass_dalton
50541
uniprot
proteins
protein_family
SPAG8 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17187156
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20488182
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
37295417
uniprot
proteins
pubmed
37865089
uniprot
proteins
pubmed
37989994
uniprot
proteins
sequence_length
470
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20488182}. Nucleus {ECO:0000269|PubMed:20488182}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:17187156, ECO:0000269|PubMed:20488182}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000250|UniProtKB:Q99932}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q99932}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:E1BNS6}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:37295417, ECO:0000269|PubMed:37865089, ECO:0000269|PubMed:37989994}. Note=In mature sperm cells, detected in the acrosomal region of the head and in the middle piece of the tail (PubMed:20488182). Localized to the nucleus and cytoplasm of spermatocytes and round spermatids while, in elongating spermatids, expressed in the cytoplasm but not in the nucleus (PubMed:20488182). During the cell cycle, localized on the microtubule-organizing center (MTOC) during prophase. In metaphase, extends along spindle microtubules. In anaphase, detected on the astral microtubules and mid-zone. In telophase, remains at the mid-zone. After cytokinesis, returns to the MTOC (By similarity). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme (By similarity). {ECO:0000250|UniProtKB:E1BNS6, ECO:0000250|UniProtKB:Q99932, ECO:0000269|PubMed:20488182}.
uniprot
proteins