Fat2
entrez
65048
canonical
uniprot
O88277
canonical
ensembl
ENSRNOG00000012575
resolver
ensp
ENSRNOP00000055459
resolver
enst
ENSRNOT00000058665
resolver
genesymbol
Fat2
resolver
genesymbol_syn
Fath2
resolver
genesymbol_syn
Megf1
resolver
uniprot
F1LPM1
resolver
uniprot_entry
F1LPM1_RAT
resolver
uniprot_entry
FAT2_RAT
resolver
amino_acid_sequence
MTLVLLGLAILLLHRAACEKSLEETIPPLSWRFTHSLYNATIYENSAPKTYVESPVKMGMYLAEPHWVVKYRIISGDAAGVFKTEEHVVGNFCFLRIRTKSSNTALLNREVRDSYTLIVQASDKSLEFEALTQVVVHILDQNDLKPLFSPPSYRVTISEDRPLKSPICKVTATDADLGQNAEFYYAFNARSEVFAIHPTSGVVTVAGKLNVTRRGKYELQVLAVDRMRKISEGNGFGNLASLVIRVEPVHRKPPAINLVVLNPPEGDEGDIYAIVTVDTNGSGAEVDSLEVVGGDPGKYFKVLRSYAQGNEFNLVAVRDINWAEHPHGFNISLQTHSWSRFPPHSIIRAFHLPSWKLANLRFEKAVYRVKLSEFSPPGSRVALVKVTTALPNLRYSLKPSSRNTAFKLNARTGLITTTKLVDFHEQNQYQLHVKTSLGQATTTVIIDIVDCNNHAPVFNRSSYEGTLDENIPPGTSVLTVTATDQDHGDNGHITYSIAGPKAVPFSIDPLLGVISTTKPMDYELMKRIYTFRVRASDWGSPFRQEKEVSVSLRLKNLNDNQPMFEEVNCTVSLRQDVPVGKSIMAVSAIDMDELQNLKYEIVSGNEQDYFHLNHFSGVISLKRSFMNLTAVRPTIYSLKITASDGKNYASPTTLKVTVVKDPHSEVPVQCDKTGVLTHITKTILQSAGLQSQELGEEEFTSLSNYQINHHSPQFEDHFPQSIDILEQVPINTPLARLAATDPDTGFHGKLVYVISDGNEEGCFDIELETGLLMVAAALDYETTSFYVLNVTVYDLGTPPKSSWKLLTVTVKDWNDNPPRFPPGGYQLTISEDTEVGTTIAELKTEDADSEDNRRVRYTLLTPTEKFSLHPFTGELVVTGHLDRESESQYILKAEARDQPTKGHQLFSVTDLIVTLEDINDNPPQCITEHRRLKVPEDMPLGTVLTFLDASDPDLGPAGEVKYILVEDAHGTFQVHPMTGALSLEKELDFERRAGYNLSFWASDSGKPLSRRTLCHVEVLVMDVNENLHSPHFSSFVYQGQVQENSPAGTPVMVVTAQDDDSGLDGELQYFLRAGTGLETFSINQDTGMLETLAPLDREFTPYYWLTVLAVDRGSVPLSAVTEVYIEVTDINDNIPSMSRPVFYPSVLEDAPLGTSVLQLEAWDPDSSSQGKLTFNLTSGNHLGHFIVHPFTGLLTTAKQLDRENKDEYVLEVTVQDNGDPSLRSTSRVVVCILDVNDNPPMFSHKLFNVRLSERLSPLSPEPVYRLVASDPDEGLNGSVTYSIEESDEESFRIDPVTGVVSSSSTFAAGEYNILTIKATDSGQPALSTSVRLHIEWIPQPRPSSIPLSFDESYYSFTVMETDPVNHMVGVISVEGRPGLFWFHISDGDKDMDFDIEKTTGSIVIARPLDTRRKSSYNLTVEVTDGFHTIATQVHIFMIANINHHRPQFLQDHYEIRVPQDTLPGVELLRVQATDQDHGKGLIYTILSSQDPGSANLFQLDPSSGVLVTVGTLELHSGPSQHILTVMVRDQEMPIKRNFVWVTIHVEDGNLHSPHFTQLRYEANVPDTTAPGTELLQVRAVDADRGANAEIHYSFLKGNSDGFFNIDSLLGIITVAQRLYHVHLTRHALTVKAEDQGSPRRHDLALVVIHVHPSDSSAPVFSKDEYFIEIPESVPIGSPILLLSAGSSSEVTYELREGNKDSVFSMNSYSGLISTQKRLDHEKVPSYRLRIRGSNMAGVFTEVVALVYIIDENDNPPAFGKPTFLGHISEAAPLHSLILGEDNSPLVVRASDSDREANSLLVYKILEPEALKFFKIDPSMGTLTTTSELDFEDTPLFQFNIYVHDQGTPILFAPRSAKVIIHVRDVNDSPPRFSEQIYEVAVVEPIHPGMGLLTVQAEDNDSRVTYSIKTSNADEAVTIHPTTGQISVVNPATLRLFQKFSIRASDGLYHDTAVVKISLTQVLDKSLQFDQDVYRARVTENTPHRKALVILGVHGNHLNDTLSYFLLNGTDLFHMIESAGVLQTRGGTFDREQQDTHEVAVEVRDNRVPQRVAQALVRVSVEDVNDNIPEFQHLPYYTVIQDGTEPGDVLFQVSATDKDLGANGSVTYGFAEDYAYFRIDPYVGDISLKKPFDYQALNKYHLRVIARDSGIPPLQTEVEVHVTVRNKSNPLFQSPYYKVKVPENITLYTPILHTQARSPEGLRLIYNIVEEEPLMLFTTDFKTGVLTVTGPLDYESKNKHVFTVRATDTALGSFSEATVEVLVEDINDNPPTFSQLVYTTSVSEGSPAQTPVIQLLASDQDSGQNQDVSYQIVEDGSDVSKFFRINGSTGEIFTIQELDYETHQHFRVKVRAMDKGDPPLTGETLVVVNVSDINDNPPKFREPQYEANVSELATCGHLVLKVQALDPDIGDTSRLEYLILSGNQDRHFSINSTSGIISMFNLCKKQLDSSYNLRVGASDGVFRATVPVYINTTNANKYSPEFQQNVYEAELAENAKVGTKVIELLAIDKDSGPYGTVDYTIINKLAGERFFINPRGQITTLQKLDRENSTERVIAIKVMARDGGGKVAFCTVKIILTDENDNAPQFKASGYTVSIPSNVSRDSPIIQVLAYDADEGRNADVTYSVDSTEDLAEEIIEVNPTTGVVKVKESLVGLENRAVDFNIKAQDGGPPHWDSLVPVRLQVVPNEIPLPKFSEPLYTFSAPEDLPEGSEIGSVKAVAAQDPIIYSLVQGTTPESNSDDVFSLDQDTGVLKVRKAMDHESTKWYQIDLMAHCPHEDTDLVSLVSVSIQVEDVNDNRPVFEADPYKAFLTENMPGGTTVIQVTANDQDTGSDGQVSYRLSVEPGSNIHELFAVDSESGWITTLQELDCETQQTYRFYVVAFDHGQTIQLSSQALVEVSITDENDNPPRFASEDYRGSVVENNEPGELVATLKTLDADVSDQNRQVTCYITEGDPLGQFSISQVGDEWRISSRKTLDREHIAKYLLRVTASDGKFQASVPVEVFVVDINDNSPQCSQLLYTGKVREDVTPGHFILKVSAIDVDMDTNAQITYSLHGPGAQEFKLDPHTGELTTLTVLDRERKDVYNLVAKATDGGGQSCQAEVTLHIEDVNDNAPRFFPSHCDVAVFDNTTVKTPVAVVFARDPDQGANAQVVYSLTDSADGQFSIDATSGVIRLEKPLQVRASSAVELTVRASDLGTPIPLSTLGTVTVSVVGLEDYLPIFLNAEHSTQVPEDAPIDMEVLHLATLTRPGSEKTGYHITGGNEQGKFRLDAHTGILYVNGSLDFETNPKYFLSIECSRKSSSSLSDVTTIVINVTDVNEHHPRFTHDLYTVRVLENAVVGDVILTVSASDDDGPVNSAITYSLVGGNQLGHFTINPKKGKLQVAKALDWEQTPSYSLRLRATDSGQPPLHEDTEVAVEVVDVNDNPPRFFQLNYSTSVQENSPIGIKVLQLILDDPDSPQNGPPYFFRITEGNTGSVFRVTPDGWLVTAASLSKKAREWYQLHIEVSDSGLPPLSSSTLVRVQVTEQSRYPPSTLPLEISITKGEEEFQGGMIGKIHATDRDPQDTLTYSLEQEGGLDRYFTVGASDGKIIASQGLPHGRYSFNVTVSDGTFTTTTGVHVHVWHMEPEVPQQAVWLGFHQLTPEELVSDHWRNLQRFLSNLLDVKRANIHLASLQPAEVTAGVDVLLVFERHSGTSYDLQELASAIAHSVREIEHSVGIRMRSALPVVPCQGQSCQDQTCQETVSLEPRVGPSYSTARLSILTPRHHLGRNCSCNGTTLRFSGQSYVQYRPLEAQNWQIHFYLKTLQPWALLMFTNETASISLKLANGFSHLEYHCPGGFYGNLSSRYPVNDGQWHSMLLEERDTSVHLLVDITDNASLVIPEECQGLRTERQLLLGGLVPSNPSSNVSLGFEGCLDAVVVNGERLELLGREKKMEGRLETWALSQCCWPGTACSQSPCLNGGSCSPALGSGYLCRCPPPFSGRNCELGRENCTSAPCQEGGTCVSSPEGTSCNCPHPYTGDRCEMEARGCSGGHCLITPEIKRGDWGQQEFLVITVALPLVIIATVGLLLYCRRRKSHKPVTMEDPDLLARSIGVDTQASPAIELDPLNTSSCNNLNQPEPSKTSVPNELVTFGPSSKQRPMVCSVPPRLPPAAVSSHPGHEPIIKRTWSGEELVYPSGAAVWPPTYSRKKHWEYPHPETMQGTLPPSPRRHVGPAVMPDPTGLYGGFPFPLELENKRAPLPPRYSNQNLEDLMPPRPPSPREHLLAPCLNEYTAISYYHSQFRQGGGGPCLAEGGYKGVSMRLSRAGPSYADCEVNGGPATGRSQPRAPPNYEGSDMVESDYGSCEEVMF
uniprot
proteins
function
FUNCTION: Involved in the regulation of cell migration (PubMed:29053796). May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (PubMed:12213440). {ECO:0000269|PubMed:29053796, ECO:0000303|PubMed:12213440}.
uniprot
proteins
mass_dalton
480654
uniprot
proteins
mutagenesis
MUTAGEN 3588; /note="K->N: Increased localization to Golgi apparatus. Has no effect on cell migration."; /evidence="ECO:0000269|PubMed:29053796"; MUTAGEN 3651; /note="R->Q: Increased localization to Golgi apparatus. Has no effect on cell migration."; /evidence="ECO:0000269|PubMed:29053796
uniprot
proteins
pubmed
12213440
uniprot
proteins
pubmed
29053796
uniprot
proteins
pubmed
9693030
uniprot
proteins
sequence_length
4351
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cell junction {ECO:0000250|UniProtKB:Q9NYQ8}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:12213440, ECO:0000269|PubMed:29053796}. Note=Localized at adhesion zippers (early state of adherens junctions) of keratinocytes. {ECO:0000250|UniProtKB:Q9NYQ8}.
uniprot
proteins
transmembrane_region
TRANSMEM 4051..4071; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins