Aars1
entrez
234734
canonical
uniprot
Q8BGQ7
canonical
ensembl
ENSMUSG00000031960
resolver
ensp
ENSMUSP00000034441
resolver
ensp
ENSMUSP00000296688
resolver
ensp
ENSMUSP00000326087
resolver
enst
ENSMUST00000034441
resolver
genesymbol
Aars1
resolver
genesymbol_syn
AARS
resolver
genesymbol_syn
Aars
resolver
uniprot
Q3UD67
resolver
uniprot
Q8BXR0
resolver
uniprot_entry
Q3UD67_MOUSE
resolver
uniprot_entry
SYAC_MOUSE
resolver
uniprot_sec
Q8BXR0
resolver
activity_regulation
ACTIVITY REGULATION: The protein lactyltransferase activity is inhibited by beta-alanine. {ECO:0000250|UniProtKB:P49588}.
uniprot
proteins
amino_acid_sequence
MDATLTAREIRERFINFFRRNEHTYVHSSATIPLDDPTLLFANAGMNQFKPIFLNTIDPSHPMAKLSRAANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGSWSFGDYFKELACKMALELLTQEFGIPVERLYVTYFGGDEAAGLEPDLECRQIWQNLGLDEARILPGNMKDNFWEMGDTGPCGPCSEIHYDRIGGRDAAHLVNQDDPNVLEIWNLVFIQYNRESDGVLKPLPKKSIDTGMGLERLVSVLQNKMSNYDTDLFMPYFEAIQKGTGARPYTGKVGAEDADGIDMAYRVLADHARTITVALADGGRPDNTGRGYVLRRILRRAVRYSHEKLNASRGFFATLVDVVVQSLGDAFPELKKDPEMVKDIINEEEVQFLKTLSRGRRILDRKIQSLGDCKTIPGDTAWLLYDTYGFPVDLTGLIAEEKGLVVDMNGFEEERRLAQLKSQGKGAGDEDLIMLDIYAIEELRAKGLEATDDSPKYNYQSDSSGSYVFECTVATVLALRREKMFVDEVVTGQECGVVLDKTCFYAEQGGQIYDEGYLVKVDDSSEDKTEFTVKNAQVRGGYVLHIGTIYGNLKVGDQVRLFIDEPRRRPVMSNHTATHILNFALRSVLGEADQKGSLVAPDRLRFDFTAKGAMSTQQIKKAEEIVNGMIEAAKPVYTQDCPLAAAKAIQGLRAVFDETYPDPVRVVSIGVPVSELLDDPCGPAGSLTSVEFCGGTHLRNSSHAGAFVIVTEEAIAKGIRRIVAVTGAEAQKALRKSETLKKSLSAMEAKVKAQTAPNKDVQREIADLGEALATAVIPQWQKDEQRETLKSLKKVMDDLDRASKADVQKRVLEKTKQLIDSNPNQPLVILEMESGASAKALNEALKLFKTHSPQTSAMLFTVDNEAGKITCLCQVPQNAANRGLKASEWVQQVSGLMDGKGGGKDMSAQATGKNVGCLQEALQLATSFAQLRLGDVKN
uniprot
proteins
disease_involvement
DISEASE: Note=In sticky (sti); homozygous mice display an unkempt sticky appearance of fur and show cerebellar Purkinje cell loss and ataxia. Defects are caused by impaired ability to edit incorrectly charged tRNA(Ala), resulting in a two-fold increase in Ser-mischarged tRNA(Ala). This results in formation of ubiquitinated protein aggregates in cerebellar Purkinje cells and degeneration of these neurons. {ECO:0000269|PubMed:16906134}.
uniprot
proteins
ec_number
6.-.-.-
uniprot
proteins
ec_number
6.1.1.7
uniprot
proteins
function
FUNCTION: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala) (PubMed:16906134, PubMed:20010690, PubMed:25422440, PubMed:27622773). Also edits incorrectly charged tRNA(Ala) via its editing domain (PubMed:16906134, PubMed:20010690, PubMed:25422440, PubMed:29769718). In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as TEAD1, TP53/p53 and YAP1. Protein lactylation takes place in a two-step reaction: lactate is first activated by ATP to form lactate-AMP and then transferred to lysine residues of target proteins. Acts as an inhibitor of TP53/p53 activity by catalyzing lactylation of TP53/p53. Acts as a positive regulator of the Hippo pathway by mediating lactylation of TEAD1 and YAP1. {ECO:0000255|HAMAP-Rule:MF_03133, ECO:0000269|PubMed:16906134, ECO:0000269|PubMed:20010690, ECO:0000269|PubMed:25422440, ECO:0000269|PubMed:27622773, ECO:0000269|PubMed:29769718}.
uniprot
proteins
mass_dalton
106909
uniprot
proteins
mutagenesis
MUTAGEN 448; /note="A->Q: Decreases misincorporation of Cys instead of Ala."; /evidence="ECO:0000269|PubMed:27622773"; MUTAGEN 723; /note="C->A: Homozygous embryos die at midgestation. Defects are caused by a dramatic increase in production of Ser-mischarged tRNA(Ala)."; /evidence="ECO:0000269|PubMed:25422440
uniprot
proteins
post_translational_modification
PTM: ISGylated. {ECO:0000255|HAMAP-Rule:MF_03133, ECO:0000269|PubMed:16139798}.; PTM: Methylation at 'Lys-943' by METTL21C. {ECO:0000250|UniProtKB:P49588}.
uniprot
proteins
protein_family
Class-II aminoacyl-tRNA synthetase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16139798
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16906134
uniprot
proteins
pubmed
20010690
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25422440
uniprot
proteins
pubmed
27622773
uniprot
proteins
pubmed
29769718
uniprot
proteins
pubmed
32611769
uniprot
proteins
sequence_length
968
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03133}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03133}. Note=Translocates to the nucleus in response to increased levels of lactate; nuclear translocation is dependent on KPNA4. {ECO:0000255|HAMAP-Rule:MF_03133}.
uniprot
proteins