Sfn
entrez
55948
canonical
uniprot
O70456
canonical
ensembl
ENSMUSG00000047281
resolver
ensp
ENSMUSP00000050374
resolver
enst
ENSMUST00000057311
resolver
genesymbol
Sfn
resolver
genesymbol_syn
Mkrn3
resolver
uniprot
Q3TEZ1
resolver
uniprot_entry
1433S_MOUSE
resolver
uniprot_sec
Q3TEZ1
resolver
amino_acid_sequence
MERASLIQKAKLAEQAERYEDMAAFMKSAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEGSEEKGPEVKEYREKVETELRGVCDTVLGLLDSHLIKGAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWTADSAGEEGGEAPEEPQS
uniprot
proteins
function
FUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (By similarity). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (By similarity). Binding generally results in the modulation of the activity of the binding partner (By similarity). Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response (By similarity). Also acts as a TP53/p53-regulated inhibitor of G2/M progression (By similarity). When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (PubMed:16710422). Acts to maintain desmosome cell junction adhesion in epithelial cells via interacting with and sequestering PKP3 to the cytoplasm, thereby restricting its translocation to existing desmosome structures and therefore maintaining desmosome protein homeostasis (By similarity). Also acts to facilitate PKP3 exchange at desmosome plaques, thereby maintaining keratinocyte intercellular adhesion (By similarity). May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (By similarity). Upstream regulator of YAP1 localization in keratinocytes: binds and sequester YAP1 in the cytoplasm, limiting YAP1-dependent transcription and driving Hippo signaling and cell differentiation (PubMed:25668240, PubMed:32369015). {ECO:0000250|UniProtKB:P31947, ECO:0000269|PubMed:16710422, ECO:0000269|PubMed:25668240, ECO:0000269|PubMed:32369015}.
uniprot
proteins
mass_dalton
27706
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation. {ECO:0000250|UniProtKB:P31947}.
uniprot
proteins
protein_family
14-3-3 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16710422
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20478393
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25668240
uniprot
proteins
pubmed
26047703
uniprot
proteins
pubmed
29678907
uniprot
proteins
pubmed
32369015
uniprot
proteins
sequence_length
248
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16710422}. Nucleus {ECO:0000269|PubMed:16710422}. Secreted {ECO:0000250|UniProtKB:P31947}. Note=May be secreted by a non-classical secretory pathway. {ECO:0000250|UniProtKB:P31947}.
uniprot
proteins