Oga
entrez
76055
canonical
uniprot
Q9EQQ9
canonical
ensembl
ENSMUSG00000025220
resolver
ensp
ENSMUSP00000026243
resolver
ensp
ENSMUSP00000268522
resolver
ensp
ENSMUSP00000268535
resolver
genesymbol
Oga
resolver
genesymbol_syn
Hexc
resolver
genesymbol_syn
Kiaa0679
resolver
genesymbol_syn
Mgea5
resolver
uniprot
Q3ULY7
resolver
uniprot
Q6ZQ71
resolver
uniprot
Q8BK05
resolver
uniprot
Q8BTT2
resolver
uniprot
Q8CFX2
resolver
uniprot
Q9CSJ4
resolver
uniprot
Q9CUR7
resolver
uniprot_entry
OGA_MOUSE
resolver
uniprot_sec
Q3ULY7
resolver
uniprot_sec
Q6ZQ71
resolver
uniprot_sec
Q8BK05
resolver
uniprot_sec
Q8BTT2
resolver
uniprot_sec
Q8CFX2
resolver
uniprot_sec
Q9CSJ4
resolver
uniprot_sec
Q9CUR7
resolver
amino_acid_sequence
MVQKESQAALEERESERNANPAAASGASLEQSVAPAPGEDNPSGAGAAAVVGAAGGARRFLCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLMTLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHNMCAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPNVSQSPYLRTVGEKLLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRSTELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRKDVVMTDSEDSTVSIQIKLENEGSDEDIETDVLYSPQMALKLALTEWLQEFGVPHQYSSRQVAHSGAKTSVVDGTPLVAAPSLNATTVVTTVYQEPIMSQGAALSGEPSVLTKEEEKKQPDEEPMDMVVEKQEEAEHKNDNQILTEIVEAKMAEELRPMDTDKESMAESKSPEMSMQEDCIPDVAPMQTDEQTQKEQFVPGPNEKPLYTAEPVTLEDLQLLADLFYLPYEHGPKGAQMLREFQWLRANSSVVSVNCKGKDSEKIEEWRSRAAKFEEMCALVMGMFTRLSNCANRTILYDMYSYVWDIKSIMSMVKSFVQWLGCRSHSSAQFLIGDQEPWAFRGGLAGEFQRLLPIDGANDLFFQPPPLTPTSKVYTIRPYFPKDEASVYKICREMYDDGVGFPFQSQPDLIGDKLVGGLLSLSLDYCFVLEDEDGICGYALGTVDVTPFIKKCKISWIPFMQEKYTKPNGDKELSEAEKIMLSFHEEQEVLPETFLANFPSLIKMDIHKKVTDPSVAKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIAKMEGFPKDVVILGRSL
uniprot
proteins
ec_number
3.2.1.169
uniprot
proteins
function
FUNCTION: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins (PubMed:16517082). Deglycosylates a large and diverse number of proteins, such as CRYAB, ELK1, GSDMD, LMNB1 and TAB1 (By similarity). Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro) (PubMed:16517082). Does not bind acetyl-CoA and does not have histone acetyltransferase activity (By similarity). {ECO:0000250|UniProtKB:O60502, ECO:0000269|PubMed:16517082}.
uniprot
proteins
mass_dalton
103162
uniprot
proteins
mutagenesis
MUTAGEN 166; /note="C->S: No change in substrate affinity but 60% reduction in O-GlcNAcase activity."; /evidence="ECO:0000269|PubMed:16517082"; MUTAGEN 174; /note="D->N: 2-fold increase in substrate affinity and 77% reduction in O-GlcNAcase activity. Regains appreciable level of catalytic efficiency in the acidic pH range. No recovery of activity in the presence of sodium azide."; /evidence="ECO:0000269|PubMed:16517082"; MUTAGEN 175; /note="D->A: 3-fold increase in substrate affinity and 90% reduction in O-GlcNAcase activity. Regains appreciable level of catalytic efficiency in the acidic pH range. 70% recovery of activity in the presence of sodium azide."; /evidence="ECO:0000269|PubMed:16517082"; MUTAGEN 177; /note="D->N: 2-fold decrease in substrate affinity and 96% reduction in O-GlcNAcase activity. Regains appreciable level of catalytic efficiency in the acidic pH range. 40% recovery of activity in the presence of sodium azide."; /evidence="ECO:0000269|PubMed:16517082"; MUTAGEN 878; /note="C->S: No effect on O-GlcNAcase activity."; /evidence="ECO:0000269|PubMed:16517082
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved by caspase-3 during apoptosis. The fragments interact with each other; cleavage does not decrease enzyme activity. {ECO:0000250|UniProtKB:O60502}.
uniprot
proteins
protein_family
Glycosyl hydrolase 84 family
uniprot
proteins
pubmed
11341771
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16356930
uniprot
proteins
pubmed
16517082
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23395175
uniprot
proteins
pubmed
24563466
uniprot
proteins
sequence_length
916
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24563466}. Nucleus {ECO:0000250|UniProtKB:Q8VIJ5}.
uniprot
proteins