Traf3ip2
entrez
103213
canonical
uniprot
Q8N7N6
canonical
ensembl
ENSMUSG00000019842
resolver
ensp
ENSMUSP00000019987
resolver
enst
ENSMUST00000019987
resolver
genesymbol
Traf3ip2
resolver
uniprot
Q8BH33
resolver
uniprot_entry
CIKS_MOUSE
resolver
uniprot_sec
Q8BH33
resolver
amino_acid_sequence
MNRSIPVEVDESEPFPSQLLKPIPEYSPEEELEPPAPNTRNMAPSSLSVLQCPPLKLANHQPVSQQVTCLRAKVLEEGEASFFRRHPELGKDISSCSSGASEPESELGALPPEHRFTLTEKRNRWLGSQLSAASPDTGHESDKSDPSLPNALADSFSGGQEMMPRPRPRPGPHRHRAAPDVPTIDTGYDSQPQDVLGIRQLERPLPLTSSCYLQDLPGPLRSRELPPQFELERYPMNAQLLPPHPSPQAPWNCQYYCPGGPYHHQVPHGHGYPPAAAYQQVLQPALPGQVLPGARARGPRPVQKVILNDSSPQDQEERPAQRDFSFPRLPRDQLYRPPSNGVEAPEESLDLPAELRPHGPQAPSLAAVPRPPSNPLARGTLRTSNLPEELRKVFITYSMDTAMEVVKFVNFLLVNGFQTAIDIFEDRIRGIDIIKWMERYLRDKTVMIIVAISPKYKQDVEGAESQLDEDEHGLHTKYIHRMMQIEFISQGSMNFRFIPVLFPNAKKEHVPTWLQNTHVYSWPKNKKNILLRLLREEEYVAPPRGPLPTLQVVPL
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase that catalyzes 'Lys63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling (By similarity). Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein (By similarity). Essential adapter molecule in IL17A-mediated signaling (PubMed:19825828). Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways (PubMed:19825828). {ECO:0000250|UniProtKB:O43734, ECO:0000269|PubMed:19825828, ECO:0000269|PubMed:33723527}.
uniprot
proteins
mass_dalton
62440
uniprot
proteins
mutagenesis
MUTAGEN 286; /note="L->G: Impairs IL17A-mediated signaling."; /evidence="ECO:0000269|PubMed:19825828
uniprot
proteins
pubmed
12466851
uniprot
proteins
pubmed
12477932
uniprot
proteins
pubmed
19825828
uniprot
proteins
pubmed
33723527
uniprot
proteins
sequence_length
555
uniprot
proteins