Rassf5
entrez
54354
canonical
uniprot
Q5EBH1
canonical
ensembl
ENSMUSG00000026430
resolver
ensp
ENSMUSP00000027688
resolver
ensp
ENSMUSP00000067011
resolver
ensp
ENSMUSP00000108061
resolver
enst
ENSMUST00000112442
resolver
genesymbol
Rassf5
resolver
genesymbol_syn
Nore1
resolver
genesymbol_syn
Rapl
resolver
uniprot
D3Z6G2
resolver
uniprot
O70407
resolver
uniprot
Q6KAR0
resolver
uniprot
Q8C2E8
resolver
uniprot_entry
D3Z6G2_MOUSE
resolver
uniprot_entry
RASF5_MOUSE
resolver
uniprot_sec
O70407
resolver
uniprot_sec
Q6KAR0
resolver
uniprot_sec
Q8C2E8
resolver
amino_acid_sequence
MASPAIGQRPYPLLLDPEPPRYLQSLGGTEPPPPARPRRCIPTALIPAAGASEDRGGRRSGRRDPEPTPRDCRHARPVRPGLQPRLRLRPGSHRPRDVRSIFEQPQDPRVLAERGEGHRFVELALRGGPGWCDLCGREVLRQALRCANCKFTCHSECRSLIQLDCRQKGGPALDRRSPESTLTPTLNQNVCKAVEETQHPPTIQEIKQKIDSYNSREKHCLGMKLSEDGTYTGFIKVHLKLRRPVTVPAGIRPQSIYDAIKEVNPAATTDKRTSFYLPLDAIKQLHISSTTTVSEVIQGLLKKFMVVDNPQKFALFKRIHKDGQVLFQKLSIADYPLYLRLLAGPDTDVLSFVLKENETGEVEWDAFSIPELQNFLTILEKEEQDKIHQLQKKYNKFRQKLEEALRESQGKPG
uniprot
proteins
function
FUNCTION: Potential tumor suppressor. Seems to be involved in lymphocyte adhesion by linking RAP1A activation upon T-cell receptor or chemokine stimulation to integrin activation. Isoform 2 stimulates lymphocyte polarization and the patch-like distribution of ITGAL/LFA-1, resulting in an enhanced adhesion to ICAM1. Together with RAP1A may participate in regulation of microtubule growth. The association of isoform 2 with activated RAP1A is required for directional movement of endothelial cells during wound healing (By similarity). May be involved in regulation of Ras apoptotic function. The RASSF5-STK4/MST1 complex may mediate HRAS and KRAS induced apoptosis. {ECO:0000250, ECO:0000269|PubMed:11864565}.
uniprot
proteins
mass_dalton
46714
uniprot
proteins
mutagenesis
MUTAGEN 220; /note="C->A: Reduced interaction with HRAS."; /evidence="ECO:0000269|PubMed:18596699"; MUTAGEN 220; /note="C->D: Strongly reduced interaction with HRAS."; /evidence="ECO:0000269|PubMed:18596699"; MUTAGEN 221; /note="L->A,D: Strongly reduced interaction with HRAS."; /evidence="ECO:0000269|PubMed:18596699"; MUTAGEN 234; /note="F->A: Reduced interaction with HRAS."; /evidence="ECO:0000269|PubMed:18596699"; MUTAGEN 236; /note="K->A: Reduced interaction with HRAS."; /evidence="ECO:0000269|PubMed:18596699"; MUTAGEN 280; /note="D->A: Reduced interaction with HRAS."; /evidence="ECO:0000269|PubMed:18596699"; MUTAGEN 283; /note="K->A: Very strong reduction of the interaction with HRAS."; /evidence="ECO:0000269|PubMed:18596699"; MUTAGEN 284; /note="Q->A: Reduced interaction with HRAS."; /evidence="ECO:0000269|PubMed:18596699"; MUTAGEN 302; /note="K->D: Reduced specificity for HRAS and diminished discrimination between HRAS and RAP1A."; /evidence="ECO:0000269|PubMed:18596699"; MUTAGEN 303; /note="K->A: Strongly reduced interaction with HRAS."; /evidence="ECO:0000269|PubMed:18596699
uniprot
proteins
pubmed
11857081
uniprot
proteins
pubmed
11864565
uniprot
proteins
pubmed
12845325
uniprot
proteins
pubmed
15449545
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16698549
uniprot
proteins
pubmed
18596699
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9488663
uniprot
proteins
sequence_length
413
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Isoform 2 is mainly located in the perinuclear region of unstimulated primary T-cells. Upon stimulation translocates to the leading edge and colocalizes with ITGAL/LFA-1 in the peripheral zone of the immunological synapse. Isoform 2 is localized to growing microtubules in vascular endothelial cells and is dissociated from microtubules by activated RAP1A (By similarity). {ECO:0000250}.
uniprot
proteins