GRB14
entrez
2888
canonical
uniprot
Q14449
canonical
ensembl
ENSG00000115290
resolver
ensp
ENSP00000263915
resolver
ensp
ENSP00000512640
resolver
ensp
ENSP00000647703
resolver
genesymbol
GRB14
resolver
hgnc
HGNC:4565
resolver
uniprot
B7Z7F9
resolver
uniprot
Q7Z6I1
resolver
uniprot_entry
GRB14_HUMAN
resolver
uniprot_sec
B7Z7F9
resolver
uniprot_sec
Q7Z6I1
resolver
amino_acid_sequence
MTTSLQDGQSAASRAAARDSPLAAQVCGAAQGRGDAHDLAPAPWLHARALLPLPDGTRGCAADRRKKKDLDVPEMPSIPNPFPELCCSPFTSVLSADLFPKANSRKKQVIKVYSEDETSRALDVPSDITARDVCQLLILKNHYIDDHSWTLFEHLPHIGVERTIEDHELVIEVLSNWGIEEENKLYFRKNYAKYEFFKNPMYFFPEHMVSFATETNGEISPTQILQMFLSSSTYPEIHGFLHAKEQGKKSWKKIYFFLRRSGLYFSTKGTSKEPRHLQFFSEFGNSDIYVSLAGKKKHGAPTNYGFCFKPNKAGGPRDLKMLCAEEEQSRTCWVTAIRLLKYGMQLYQNYMHPYQGRSGCSSQSISPMRSISENSLVAMDFSGQKSRVIENPTEALSVAVEEGLAWRKKGCLRLGTHGSPTASSQSSATNMAIHRSQPWFHHKISRDEAQRLIIQQGLVDGVFLVRDSQSNPKTFVLSMSHGQKIKHFQIIPVEDDGEMFHTLDDGHTRFTDLIQLVEFYQLNKGVLPCKLKHYCARIAL
uniprot
proteins
function
FUNCTION: Adapter protein which modulates coupling of cell surface receptor kinases with specific signaling pathways. Binds to, and suppresses signals from, the activated insulin receptor (INSR). Potent inhibitor of insulin-stimulated MAPK3 phosphorylation. Plays a critical role regulating PDPK1 membrane translocation in response to insulin stimulation and serves as an adapter protein to recruit PDPK1 to activated insulin receptor, thus promoting PKB/AKT1 phosphorylation and transduction of the insulin signal. {ECO:0000269|PubMed:15210700, ECO:0000269|PubMed:19648926}.
uniprot
proteins
mass_dalton
60988
uniprot
proteins
mutagenesis
MUTAGEN 140; /note="K->A: Partial loss of INSR-binding. Loss of inhibition of AKT1 activation. Loss of inhibition of MAPK3 phosphorylation. Loss of NRAS-binding."; /evidence="ECO:0000269|PubMed:19648926"; MUTAGEN 245; /note="E->G: 4-fold increase in PI(3,4,5)P3-binding affinity; when associated with S-246."; /evidence="ECO:0000269|PubMed:19648926"; MUTAGEN 246; /note="Q->S: 4-fold increase in PI(3,4,5)P3-binding affinity; when associated with G-245."; /evidence="ECO:0000269|PubMed:19648926"; MUTAGEN 252; /note="K->A: Partial loss of INSR-binding. Loss of inhibition of AKT1 activation. Loss of inhibition of MAPK3 phosphorylation. Loss of translocation to the plasma membrane upon insulin-stimulation. More than 3-fold decrease in PI(3,4,5)P3-binding affinity."; /evidence="ECO:0000269|PubMed:19648926"; MUTAGEN 299; /note="G->N: No effect on PI(3,4,5)P3-binding."; /evidence="ECO:0000269|PubMed:19648926"; MUTAGEN 348; /note="Q->A: Loss of inhibition of AKT1 activation; when associated with A-349. Loss of inhibition of MAPK3 phosphorylation; when associated with A-349. No effect on INSR-binding; when associated with A-349."; /evidence="ECO:0000269|PubMed:19648926"; MUTAGEN 349; /note="N->A: Loss of inhibition of AKT1 activation; when associated with A-348. Loss of inhibition of MAPK3 phosphorylation; when associated with A-348. No effect on INSR-binding; when associated with A-348."; /evidence="ECO:0000269|PubMed:19648926
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine residues. Phosphorylated on tyrosine residues by TEK/TIE2. {ECO:0000269|PubMed:20973951}.
uniprot
proteins
protein_family
GRB7/10/14 family
uniprot
proteins
pubmed
11726652
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15210700
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16246733
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19648926
uniprot
proteins
pubmed
20973951
uniprot
proteins
pubmed
21220648
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8647858
uniprot
proteins
sequence_length
540
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15210700, ECO:0000269|PubMed:19648926}. Endosome membrane {ECO:0000269|PubMed:15210700, ECO:0000269|PubMed:19648926}; Peripheral membrane protein {ECO:0000269|PubMed:15210700, ECO:0000269|PubMed:19648926}. Note=Upon insulin stimulation, translocates to the plasma membrane. {ECO:0000269|PubMed:15210700, ECO:0000269|PubMed:19648926}.
uniprot
proteins