Ddit3
entrez
13198
canonical
uniprot
P35639
canonical
ensembl
ENSMUSG00000025408
resolver
ensp
ENSMUSP00000026475
resolver
ensp
ENSMUSP00000118339
resolver
ensp
ENSMUSP00000252905
resolver
ensp
ENSMUSP00000252907
resolver
enst
ENSMUST00000026475
resolver
genesymbol
Ddit3
resolver
genesymbol_syn
Chop
resolver
genesymbol_syn
Chop10
resolver
genesymbol_syn
Gadd153
resolver
uniprot
Q3V405
resolver
uniprot
Q91YW9
resolver
uniprot_entry
DDIT3_MOUSE
resolver
uniprot_entry
Q3V405_MOUSE
resolver
uniprot_sec
Q91YW9
resolver
amino_acid_sequence
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
uniprot
proteins
function
FUNCTION: Multifunctional transcription factor in endoplasmic reticulum (ER) stress response (PubMed:15601821, PubMed:19752026). Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress (PubMed:15601821, PubMed:19752026). Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes (PubMed:1547942). Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes (PubMed:1547942). Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L (PubMed:12706815, PubMed:14684614, PubMed:15775988, PubMed:19919955, PubMed:21159964). Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG) (By similarity). Together with ATF4, mediates ER-mediated cell death by promoting expression of genes involved in cellular amino acid metabolic processes, mRNA translation and the unfolded protein response (UPR) in response to ER stress (PubMed:22242125, PubMed:23624402). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity (By similarity). Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response (PubMed:16670335). Acts as a major regulator of postnatal neovascularization through regulation of endothelial nitric oxide synthase (NOS3)-related signaling (PubMed:22265908). {ECO:0000250|UniProtKB:P35638, ECO:0000269|PubMed:12706815, ECO:0000269|PubMed:14684614, ECO:0000269|PubMed:1547942, ECO:0000269|PubMed:15601821, ECO:0000269|PubMed:15775988, ECO:0000269|PubMed:16670335, ECO:0000269|PubMed:19752026, ECO:0000269|PubMed:19919955, ECO:0000269|PubMed:21159964, ECO:0000269|PubMed:22242125, ECO:0000269|PubMed:22265908, ECO:0000269|PubMed:23624402}.
uniprot
proteins
mass_dalton
19189
uniprot
proteins
mutagenesis
MUTAGEN 14; /note="S->A: Loss of phosphorylation."; /evidence="ECO:0000269|PubMed:12876286"; MUTAGEN 15; /note="S->A: Loss of phosphorylation."; /evidence="ECO:0000269|PubMed:12876286"; MUTAGEN 30; /note="S->A: Loss of phosphorylation."; /evidence="ECO:0000269|PubMed:12876286"; MUTAGEN 31; /note="S->A: Loss of phosphorylation."; /evidence="ECO:0000269|PubMed:12876286
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, leading to its degradation by the proteasome. {ECO:0000250}.; PTM: Phosphorylation at serine residues by MAPK14 enhances its transcriptional activation activity while phosphorylation at serine residues by CK2 inhibits its transcriptional activation activity. {ECO:0000269|PubMed:12876286, ECO:0000269|PubMed:8650547}.
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
pubmed
12706815
uniprot
proteins
pubmed
12876286
uniprot
proteins
pubmed
14684614
uniprot
proteins
pubmed
1547942
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15601821
uniprot
proteins
pubmed
15775988
uniprot
proteins
pubmed
16670335
uniprot
proteins
pubmed
19752026
uniprot
proteins
pubmed
19855386
uniprot
proteins
pubmed
19919955
uniprot
proteins
pubmed
21159964
uniprot
proteins
pubmed
21285359
uniprot
proteins
pubmed
22242125
uniprot
proteins
pubmed
22265908
uniprot
proteins
pubmed
23624402
uniprot
proteins
pubmed
8650547
uniprot
proteins
sequence_length
168
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:1547942}. Nucleus {ECO:0000269|PubMed:22242125}. Note=Present in the cytoplasm under non-stressed conditions and ER stress leads to its nuclear accumulation. {ECO:0000269|PubMed:22242125}.
uniprot
proteins