SLC15A1
entrez
6564
canonical
uniprot
P46059
canonical
ensembl
ENSG00000088386
resolver
ensp
ENSP00000365686
resolver
enst
ENST00000376503
resolver
genesymbol
SLC15A1
resolver
genesymbol_syn
PEPT1
resolver
hgnc
HGNC:10920
resolver
uniprot
B2CQT6
resolver
uniprot
Q5VW82
resolver
uniprot_entry
B2CQT6_HUMAN
resolver
uniprot_entry
S15A1_HUMAN
resolver
uniprot_sec
Q5VW82
resolver
amino_acid_sequence
MGMSKSHSFFGYPLSIFFIVVNEFCERFSYYGMRAILILYFTNFISWDDNLSTAIYHTFVALCYLTPILGALIADSWLGKFKTIVSLSIVYTIGQAVTSVSSINDLTDHNHDGTPDSLPVHVVLSLIGLALIALGTGGIKPCVSAFGGDQFEEGQEKQRNRFFSIFYLAINAGSLLSTIITPMLRVQQCGIHSKQACYPLAFGVPAALMAVALIVFVLGSGMYKKFKPQGNIMGKVAKCIGFAIKNRFRHRSKAFPKREHWLDWAKEKYDERLISQIKMVTRVMFLYIPLPMFWALFDQQGSRWTLQATTMSGKIGALEIQPDQMQTVNAILIVIMVPIFDAVLYPLIAKCGFNFTSLKKMAVGMVLASMAFVVAAIVQVEIDKTLPVFPKGNEVQIKVLNIGNNTMNISLPGEMVTLGPMSQTNAFMTFDVNKLTRINISSPGSPVTAVTDDFKQGQRHTLLVWAPNHYQVVKDGLNQKPEKGENGIRFVNTFNELITITMSGKVYANISSYNASTYQFFPSGIKGFTISSTEIPPQCQPNFNTFYLEFGSAYTYIVQRKNDSCPEVKVFEDISANTVNMALQIPQYFLLTCGEVVFSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIVAGAGQFSKQWAEYILFAALLLVVCVIFAIMARFYTYINPAEIEAQFDEDEKKNRLEKSNPYFMSGANSQKQM
uniprot
proteins
function
FUNCTION: Electrogenic proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides. Transports neutral and monovalently charged peptides with a proton to peptide stoichiometry of 1:1 or 2:1 (By similarity) (PubMed:15521010, PubMed:18367661, PubMed:19685173, PubMed:26320580, PubMed:7896779, PubMed:8914574, PubMed:9835627). Primarily responsible for the absorption of dietary di- and tripeptides from the small intestinal lumen (By similarity). Mediates transepithelial transport of muramyl and N-formylated bacterial dipeptides contributing to recognition of pathogenic bacteria by the mucosal immune system (PubMed:15521010, PubMed:9835627). {ECO:0000250|UniProtKB:P36836, ECO:0000269|PubMed:15521010, ECO:0000269|PubMed:18367661, ECO:0000269|PubMed:19685173, ECO:0000269|PubMed:7896779, ECO:0000269|PubMed:8914574, ECO:0000269|PubMed:9835627}.
uniprot
proteins
mass_dalton
78806
uniprot
proteins
mutagenesis
MUTAGEN 573; /note="D->A: Does not affect peptide transporter activity."; /evidence="ECO:0000269|PubMed:26320580"; MUTAGEN 588; /note="Y->C: Reduced peptide transporter activity."; /evidence="ECO:0000269|PubMed:19685173"; MUTAGEN 594; /note="G->A: Does not affect peptide transporter activity."; /evidence="ECO:0000269|PubMed:19685173"; MUTAGEN 594; /note="G->C: Nearly abolished peptide transporter activity."; /evidence="ECO:0000269|PubMed:19685173"; MUTAGEN 594; /note="G->V: Abolished peptide transporter activity."; /evidence="ECO:0000269|PubMed:19685173"; MUTAGEN 595; /note="E->C: Nearly abolished peptide transporter activity."; /evidence="ECO:0000269|PubMed:19685173"; MUTAGEN 595; /note="E->D: Does not affect peptide transporter activity."; /evidence="ECO:0000269|PubMed:19685173"; MUTAGEN 595; /note="E->K,R: Abolished peptide transporter activity."; /evidence="ECO:0000269|PubMed:19685173
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family
uniprot
proteins
pubmed
12436193
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15521010
uniprot
proteins
pubmed
16258023
uniprot
proteins
pubmed
18367661
uniprot
proteins
pubmed
19685173
uniprot
proteins
pubmed
26320580
uniprot
proteins
pubmed
28408210
uniprot
proteins
pubmed
7896779
uniprot
proteins
pubmed
8914574
uniprot
proteins
pubmed
9835627
uniprot
proteins
sequence_length
708
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:28408210}; Multi-pass membrane protein {ECO:0000255}. Note=Localized to the apical membrane of enterocytes. {ECO:0000269|PubMed:28408210}.
uniprot
proteins
transmembrane_region
TRANSMEM 1..21; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 54..74; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 83..103; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 119..139; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 162..182; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 199..219; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 277..297; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 328..348; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 362..382; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 585..605; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 620..640; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 646..666; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins