Slc7a9
entrez
30962
canonical
uniprot
Q9QXA6
canonical
ensembl
ENSMUSG00000030492
resolver
ensp
ENSMUSP00000032703
resolver
ensp
ENSMUSP00000112726
resolver
ensp
ENSMUSP00000113181
resolver
ensp
ENSMUSP00000244633
resolver
enst
ENSMUST00000032703
resolver
enst
ENSMUST00000118383
resolver
enst
ENSMUST00000118969
resolver
genesymbol
Slc7a9
resolver
genesymbol_syn
Bat1
resolver
uniprot
Q3UQE3
resolver
uniprot_entry
BAT1_MOUSE
resolver
uniprot_entry
Q3UQE3_MOUSE
resolver
amino_acid_sequence
MEETSLRRRREDEKSTHSTELKTTSLQKEVGLLSGICIIVGTIIGSGIFISPKSVLANTESVGPCLIIWAACGILATLGALCFAELGTMITKSGGEYPYLMEAFGPIPAYLFSWTSLIVMKPSSFAIICLSFSEYVCAAFYSGCKPPAVVVKLLAAAAILFITTVNALSVRLGSYVQNVFTAAKMVIVAIIIISGLVFLAQGNVKNFQNSFEGTQTSVGAISLAFYNGLWAYDGWNQLNYITEELRNPYRNLPMAIVIGIPLVTVCYILMNIAYFTVMTPTELLQSQAVAVTFGDRVLYPASWVVPLFVAFSTIGAANGTCFTAGRLIYVAGREGHMLKVLSYISVKRLTPAPALIFYGIIAIIYIIPGDINSLVNYFSFAAWLFYGMTILGLVVMRFTRKDLERPIKVPLFIPIIVILVSLFLILAPIISEPAWEYLYCVLFILSGLIFYFLFVYYKFGWAQRISRPVTKHLQMLMEVVPPEKDPE
uniprot
proteins
function
FUNCTION: Associates with SLC3A1 to form a functional transporter complex that mediates the electrogenic exchange between cationic amino acids and neutral amino acids, with a stoichiometry of 1:1 (By similarity) (PubMed:10588648). Has system b(0,+)-like activity with high affinity for extracellular cationic amino acids and L-cystine and lower affinity for intracellular neutral amino acids (By similarity). Substrate exchange is driven by high concentration of intracellular neutral amino acids and the intracellular reduction of L-cystine to L-cysteine (By similarity). Required for reabsorption of L-cystine and dibasic amino acids across the brush border membrane in renal proximal tubules (By similarity). {ECO:0000250|UniProtKB:P82251, ECO:0000269|PubMed:10588648}.
uniprot
proteins
mass_dalton
53747
uniprot
proteins
protein_family
Amino acid-polyamine-organocation (APC) superfamily
uniprot
proteins
pubmed
10588648
uniprot
proteins
pubmed
10799513
uniprot
proteins
pubmed
12167606
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
487
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000305|PubMed:12167606}; Multi-pass membrane protein {ECO:0000305|PubMed:12167606}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..55; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P82251"; TRANSMEM 63..84; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P82251"; TRANSMEM 111..137; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P82251"; TRANSMEM 148..169; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P82251"; TRANSMEM 170..193; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P82251"; TRANSMEM 218..238; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P82251"; TRANSMEM 252..274; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P82251"; TRANSMEM 303..325; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P82251"; TRANSMEM 352..370; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P82251"; TRANSMEM 371..391; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P82251"; TRANSMEM 411..431; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P82251"; TRANSMEM 435..450; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P82251
uniprot
proteins