Fbxw15
entrez
382105
canonical
uniprot
L7N1X6
canonical
ensembl
ENSMUSG00000074060
resolver
ensp
ENSMUSP00000058175
resolver
ensp
ENSMUSP00000143385
resolver
genesymbol
Fbxw15
resolver
genesymbol_syn
Fbxo12J
resolver
uniprot
Q4FZL6
resolver
uniprot
Q4PLJ2
resolver
uniprot
Q8BI39
resolver
uniprot_entry
FBW15_MOUSE
resolver
uniprot_sec
Q4FZL6
resolver
uniprot_sec
Q4PLJ2
resolver
uniprot_sec
Q8BI39
resolver
amino_acid_sequence
MAIHLPCLPMMKILSYLDAYSLLQAAQVNKDWNELASSDVLWRKLCQKRWLYCDMDTLQLQGKETWKQFFIDRIWQERAKFRAKAKDFTYKEIPLMCGLFGYACYISGCGLTRKGQDKSVVCMVNSKNTISTWDVHKSVITWKSPEQPASIKLLTTLPEMHIAVTVDIQSTIKLWDCHNREALATNNLKSPCKSLKAVFTKDGPIVLIGDTLGNIHIFRIPDLYLISTVNVLPYGFDGIYCSPQKKWVLLSKKHPHILPKVFYMSSFLRTSEFSAPVSTVLKLSLYERVFWTPRREDRITLMSRSGFPQVKMFETYDIKLEEFGNKRIVKGKLIASFELQCHKVNPQRFGVSDKNVIVCSTESSLLLFDINGLRLKTFQYCPEMIVKLSVDPLHVIVICNTGSMDVYAWEERSLLLRKCYRLHIERPLPLYGFIYKAACDDVSIIQLITDELSLSSLTSYALNICS
uniprot
proteins
function
FUNCTION: Substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes KAT7 ubiquitination and subsequent degradation in collaboration with MAP2K1 kinase, leading to reduced histone H3K14 acetylation and increased cell proliferation. {ECO:0000269|PubMed:23319590}.
uniprot
proteins
mass_dalton
53586
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:23319590}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18094359
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23319590
uniprot
proteins
sequence_length
466
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18094359, ECO:0000269|PubMed:23319590}. Endoplasmic reticulum {ECO:0000269|PubMed:18094359}. Nucleus {ECO:0000269|PubMed:23319590}.
uniprot
proteins