Sla
entrez
338477
canonical
uniprot
P59622
canonical
ensembl
ENSRNOG00000056714
resolver
ensp
ENSRNOP00000072624
resolver
enst
ENSRNOT00000087116
resolver
genesymbol
Sla
resolver
genesymbol_syn
Slap
resolver
genesymbol_syn
Slap1
resolver
uniprot
A0A0G2K3G1
resolver
uniprot
A0A1W2Q6L4
resolver
uniprot_entry
A0A0G2K3G1_RAT
resolver
uniprot_entry
SLAP1_RAT
resolver
uniprot_sec
A0A1W2Q6L4
resolver
amino_acid_sequence
MLCRLPGPSTSRGEKEMGNSMKSTPAPLERPLSNTEGLESDFLAVLNDYPSPDISPPIFRRGEKLRVISDEGGWWKAISLSTGRESYIPGICVARVYHGWLFEGLGRDKAEELLQLPDTKIGSFMIRESETKKGFYSLSVRHRQVKHYRIFRLPNNWYYISPRLTFQCLEDLVTHYSEVADGLCCVLTTPCLAQNTPAPTAQPSPCTSPGSPVTLRQKTFDWKRVSSLQEGPEGAENPLRVDESLFSYGLRESIASYLSLTGDDSSNFDRKKKSLSLIYSGSKRKSSFFSAPNTLKINALAGTQKTKALTAT
uniprot
proteins
function
FUNCTION: Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
34745
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250}.
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
312
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Endosome {ECO:0000250}. Note=Colocalizes with endosomes. {ECO:0000250}.
uniprot
proteins