Aimp2
entrez
231872
canonical
uniprot
Q8R010
canonical
ensembl
ENSMUSG00000029610
resolver
ensp
ENSMUSP00000031613
resolver
ensp
ENSMUSP00000098052
resolver
enst
ENSMUST00000031613
resolver
enst
ENSMUST00000100483
resolver
genesymbol
Aimp2
resolver
genesymbol_syn
Jtv1
resolver
uniprot
E9QP67
resolver
uniprot
F6WAT7
resolver
uniprot
Q8R2Y6
resolver
uniprot
Q8R3V2
resolver
uniprot_entry
AIMP2_MOUSE
resolver
uniprot_entry
F6WAT7_MOUSE
resolver
uniprot_entry
Q8R3V2_MOUSE
resolver
uniprot_sec
E9QP67
resolver
uniprot_sec
Q8R2Y6
resolver
amino_acid_sequence
MPMYQVKPYHGGSAPLHVELPTCMYRLPNVHSKTTSPATDAGHVQETSEPSLQALESRQDDILKRLYELKAAVDGLSKMIHTPDADLDVTNILQADEPTTLATNTLDLNSVLGKDYGALKDIVINANPASPPLSLLVLHRLLCERYRVLSTVHTHSSVKNVPENLVKCFGEQARKQSRHEYQLGFTLIWKNVPKTQMKFSVQTMCPIEGEGNIARFLFSLFGQKHNAVTLTLIDSWVDIAMFQLREGSSKEKAAVFRSMNSALGRSPWLVGNELTVADVVLWSVLQQTGGSSGAAPTNVQRWLKSCENLAPFSTALQLLK
uniprot
proteins
function
FUNCTION: Required for assembly and stability of the aminoacyl-tRNA synthase complex (PubMed:12060739). Mediates ubiquitination and degradation of FUBP1, a transcriptional activator of MYC, leading to MYC down-regulation which is required for aveolar type II cell differentiation (PubMed:12819782). Blocks MDM2-mediated ubiquitination and degradation of p53/TP53 (PubMed:18695251). Functions as a proapoptotic factor (PubMed:16135753). {ECO:0000269|PubMed:12060739, ECO:0000269|PubMed:12819782, ECO:0000269|PubMed:16135753, ECO:0000269|PubMed:18695251}.
uniprot
proteins
mass_dalton
35378
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine residues in response to UV irradiation. {ECO:0000269|PubMed:18695251}.; PTM: Ubiquitinated by PRKN, leading to its degradation by the proteasome. {ECO:0000250}.
uniprot
proteins
pubmed
12060739
uniprot
proteins
pubmed
12819782
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16135753
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18695251
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
320
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:18695251}. Nucleus {ECO:0000269|PubMed:18695251}. Note=Following DNA damage, dissociates from the aminoacyl-tRNA synthase complex and translocates from the cytoplasm to the nucleus. {ECO:0000269|PubMed:18695251}.
uniprot
proteins