Atxn10
entrez
54138
canonical
uniprot
P28658
canonical
ensembl
ENSMUSG00000016541
resolver
ensp
ENSMUSP00000132450
resolver
enst
ENSMUST00000163242
resolver
genesymbol
Atxn10
resolver
genesymbol_syn
Sca10
resolver
uniprot
Q543S3
resolver
uniprot
Q99LP5
resolver
uniprot
Q9D1I1
resolver
uniprot_entry
ATX10_MOUSE
resolver
uniprot_sec
Q543S3
resolver
uniprot_sec
Q99LP5
resolver
uniprot_sec
Q9D1I1
resolver
amino_acid_sequence
MAAPRMPPSRLSGIMVPAPIQDLEALRALTALFKEQRNRETAPRTIFQRVLDILKKSTHAVELACRDPSQVEHLASSLQLITECFRCLRNACIECSVNQNSIRNLDTIGVAVDLVLLFRELRVEQDSLLTAFRCGLQFLGNVASRNEESQSIVWVHAFPELFMSCLNHPDKKIVAYCSMILFTSLNAERMKDLEENLNIAINVIEAHQKHPASEWPFLIISDHFLKSPELVEAMYGKLSNQERITLLDIVIAKLVGEEQLTKDDISIFVRHAELIANSFMDQCRNVLKLTSEPHTEDKEALVTIRLLDVLCEMTSNTELLGYLQVFPGLMERVIDVLRVIHEVGKESTNIFSPSDSLKAEGDIEHMTEGFKSHLIRLIGNLCYKNKENQDKVNELDGIPLILDSSNIDDNNPFMMQWVVYAVRNLTEDNSQNQDVIAKMEEQGLADASLLKKMGFEIEKSGDKLILKSNNDIPPP
uniprot
proteins
function
FUNCTION: May play a role in the regulation of cytokinesis (PubMed:34970537). May play a role in signaling by stimulating protein glycosylation. Induces neuritogenesis by activating the Ras-MAP kinase pathway and is necessary for the survival of cerebellar neurons (By similarity). Does not appear to play a major role in ciliogenesis (PubMed:34970537). {ECO:0000250|UniProtKB:Q9ER24, ECO:0000269|PubMed:34970537}.
uniprot
proteins
mass_dalton
53707
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated. {ECO:0000250|UniProtKB:Q9UBB4}.; PTM: Phosphorylation at Ser-12 by AURKB promotes the association of ATXN10 with PLK1. Phosphorylation at Ser-77 and Thr-82 by PLK1 may play a role in the regulation of cytokinesis and may stimulate the proteasome-mediated degradation of ATXN10. {ECO:0000250|UniProtKB:Q9UBB4}.
uniprot
proteins
protein_family
Ataxin-10 family
uniprot
proteins
pubmed
12106288
uniprot
proteins
pubmed
15201271
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16182253
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
34970537
uniprot
proteins
sequence_length
475
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9UBB4}. Midbody {ECO:0000250|UniProtKB:Q9UBB4}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:34970537}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:34970537}. Note=Localizes to the midbody during telophase. {ECO:0000250|UniProtKB:Q9UBB4}.
uniprot
proteins