Parvb
entrez
170736
canonical
uniprot
Q9ES46
canonical
ensembl
ENSMUSG00000022438
resolver
ensp
ENSMUSP00000023072
resolver
enst
ENSMUST00000023072
resolver
genesymbol
Parvb
resolver
uniprot
Q3UGT9
resolver
uniprot_entry
PARVB_MOUSE
resolver
uniprot_entry
Q3UGT9_MOUSE
resolver
amino_acid_sequence
MSSAPPRSPTPRAPKMKKDESFLGKLGGTLARKKKTREVTDLQEEGKSAINSPMAPALVDIHPEDTQLEENEERTMIDPTSREDPKFKELVKVLLDWINDVLAEERIIVKQLEEDLYDGQVLQKLLEKLAHCKLNVAEVTQSEIGQKQKLQTVLEAVQDLLRPHGWPLRWNVDSIHGKNLVAILHLLVSLAMHFRAPIHLPEHVTVQVVVVRKREGLLHSSHISEELTTTTEIMMGRFERDAFDTLFDHAPDKLNLVKKSLITFVNKHLNKLNLEVTDLETQFADGVYLVLLLGLLEDYFVPLHNFYLTPDSFDQKVHNVAFAFELMLDGGLKKPKARPEDVVNLDLKSTLRVLYTLFTKYKDVE
uniprot
proteins
function
FUNCTION: Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
41669
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by ILK. {ECO:0000250}.
uniprot
proteins
protein_family
Parvin family
uniprot
proteins
pubmed
11171322
uniprot
proteins
pubmed
11722847
uniprot
proteins
pubmed
15835269
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
365
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, focal adhesion. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cytoplasm, myofibril, sarcomere {ECO:0000250}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Constituent of focal adhesions. Detected at the tips of the leading edge of cells. Colocalizes with F-actin at the tips of lamellipodia (By similarity). {ECO:0000250}.
uniprot
proteins