Grik3
entrez
298521
canonical
uniprot
P42264
canonical
ensembl
ENSRNOG00000008992
resolver
ensp
ENSRNOP00000048216
resolver
ensp
ENSRNOP00000089586
resolver
enst
ENSRNOT00000045513
resolver
genesymbol
Grik3
resolver
genesymbol_syn
Glur7
resolver
uniprot
G3V9I2
resolver
uniprot
O35420
resolver
uniprot_entry
G3V9I2_RAT
resolver
uniprot_entry
GRIK3_RAT
resolver
uniprot_sec
O35420
resolver
amino_acid_sequence
MTAPWRRLRSLVWEYWAGFLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQSLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNAHVSAIVEKWSMERLQAAPRAESGLLDGVMMTDAALLYDAVHIVSVCYQRASQMTVNSLQCHRHKPWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFIYKLRKTAEREQRSFCSTVADEIRFSLTCQRRLKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMSCSTSLAPVFP
uniprot
proteins
function
FUNCTION: Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:1322826, PubMed:1371217, PubMed:21907808). In association with GRIK2, involved in presynaptic facilitation of glutamate release at hippocampal mossy fiber synapses (By similarity). {ECO:0000250|UniProtKB:B1AS29, ECO:0000269|PubMed:1322826, ECO:0000269|PubMed:1371217, ECO:0000269|PubMed:21907808}.; FUNCTION: [Isoform GluR7B]: Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and the glutamatergic agonist kainic acid. {ECO:0000269|PubMed:9390526}.
uniprot
proteins
mass_dalton
104071
uniprot
proteins
post_translational_modification
PTM: Mass spectrometry data suggest the protein is N-glycosylated at five distinct sites. {ECO:0000269|PubMed:20951142}.
uniprot
proteins
protein_family
GRIK3 subfamily
uniprot
proteins
protein_family
Glutamate-gated ion channel (TC 1.A.10.1) family
uniprot
proteins
pubmed
10023812
uniprot
proteins
pubmed
11122333
uniprot
proteins
pubmed
1322826
uniprot
proteins
pubmed
1371217
uniprot
proteins
pubmed
19217376
uniprot
proteins
pubmed
20951142
uniprot
proteins
pubmed
21907808
uniprot
proteins
pubmed
24090084
uniprot
proteins
pubmed
9390526
uniprot
proteins
sequence_length
919
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:10023812}; Multi-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane {ECO:0000305|PubMed:10023812}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 564..584; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 637..657; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 821..841; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins