Mrln
entrez
69563
canonical
uniprot
Q9CV60
canonical
ensembl
ENSMUSG00000019933
resolver
ensp
ENSMUSP00000150523
resolver
ensp
ENSMUSP00000328216
resolver
enst
ENSMUST00000020090
resolver
genesymbol
Mrln
resolver
genesymbol_syn
Mln
resolver
uniprot_entry
MLN_MOUSE
resolver
amino_acid_sequence
MSGKSWVLISTTSPQSLEDEILGRLLKILFVLFVDLMSIMYVVITS
uniprot
proteins
function
FUNCTION: Inhibits the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+), thereby acting as a key regulator of skeletal muscle activity. Its high expression in adult skeletal muscle, suggests that it constitutes the predominant regulator of ATP2A1/SERCA1 in adult skeletal muscle (PubMed:25640239, PubMed:26816378). Also inhibits the activity of ATP2A2/SERCA2 and ATP2A3/SERCA3 (PubMed:27923914, PubMed:31449798). {ECO:0000269|PubMed:25640239, ECO:0000269|PubMed:26816378, ECO:0000269|PubMed:27923914, ECO:0000269|PubMed:31449798}.
uniprot
proteins
mass_dalton
5175
uniprot
proteins
mutagenesis
MUTAGEN 27; /note="K->A: Does not affect interaction with ATP2A1."; /evidence="ECO:0000269|PubMed:25640239"; MUTAGEN 29; /note="L->A: Abolishes interaction with ATP2A1/SERCA1."; /evidence="ECO:0000269|PubMed:25640239"; MUTAGEN 30; /note="F->A: Abolishes interaction with ATP2A1/SERCA1."; /evidence="ECO:0000269|PubMed:25640239"; MUTAGEN 33; /note="F->A: Abolishes interaction with ATP2A1/SERCA1."; /evidence="ECO:0000269|PubMed:25640239"; MUTAGEN 35; /note="D->A: Does not affect interaction with ATP2A1."; /evidence="ECO:0000269|PubMed:25640239
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
25640239
uniprot
proteins
pubmed
26816378
uniprot
proteins
pubmed
27923914
uniprot
proteins
pubmed
31449798
uniprot
proteins
sequence_length
46
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:25640239, ECO:0000305|PubMed:27923914}; Single-pass membrane protein {ECO:0000305|PubMed:25640239}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins