Kirrel1
entrez
170643
canonical
uniprot
Q80W68
canonical
ensembl
ENSMUSG00000041734
resolver
ensp
ENSMUSP00000103243
resolver
ensp
ENSMUSP00000125525
resolver
ensp
ENSMUSP00000274518
resolver
ensp
ENSMUSP00000274519
resolver
genesymbol
Kirrel1
resolver
genesymbol_syn
Kirrel
resolver
genesymbol_syn
Neph1
resolver
uniprot
Q8CIJ4
resolver
uniprot
Q8CJ59
resolver
uniprot
Q923L4
resolver
uniprot_entry
KIRR1_MOUSE
resolver
uniprot_sec
Q8CIJ4
resolver
uniprot_sec
Q8CJ59
resolver
uniprot_sec
Q923L4
resolver
amino_acid_sequence
MTLESPSTRLMTCQSSLLPEKPRFLSQKMWAPHLVVAYLIFVTLALALPGTQTRFSQEPADQTVVAGQRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEETRIDGGPVILLQAGTPYNLTCRAFNAKPAATIIWFRDGTQQEGAVTSTELLKDGKRETTISQLLIEPTDLDIGRVFTCRSMNEAIPNGKETSIELDVHHPPTVTLSIEPQTVLEGERVIFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVYNKVGSTNVSTLVNVHFAPRIVVYPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQFAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGAGILVVFSFAALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTASISTATRVMKAIYSSFKDDVDLKQDLRCDTIDTREEYEMKDPTNGYYNVRAHEDRPSSRAVLYADYRAPGPTRFDGRPSSRLSHSSGYAQLNTYSRAPASDYGTEPTPSGPSAPGGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTSQHSDYGQRFQQRMQTHV
uniprot
proteins
function
FUNCTION: Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm (PubMed:11416156). Is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1. {ECO:0000269|PubMed:11416156}.
uniprot
proteins
mass_dalton
87176
uniprot
proteins
mutagenesis
MUTAGEN 633; /note="P->S: No effect on interaction with NPHS2."; /evidence="ECO:0000269|PubMed:12424224"; MUTAGEN 637; /note="Y->A: Inhibits interaction with NPHS2."; /evidence="ECO:0000269|PubMed:12424224
uniprot
proteins
post_translational_modification
PTM: Phosphorylation probably regulates the interaction with NPHS2. Phosphorylated at Tyr-637 and Tyr-638 by FYN, leading to GRB2 binding (By similarity). {ECO:0000250}.; PTM: N-glycosylated. {ECO:0000269|PubMed:12660326, ECO:0000269|PubMed:19349973}.
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
11416156
uniprot
proteins
pubmed
12424224
uniprot
proteins
pubmed
12660326
uniprot
proteins
pubmed
12865409
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
789
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Predominantly located at podocyte slit diaphragm.
uniprot
proteins
transmembrane_region
TRANSMEM 532..552; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins