ARFGAP3
entrez
26286
canonical
uniprot
Q9NP61
canonical
ensembl
ENSG00000242247
resolver
ensp
ENSP00000263245
resolver
ensp
ENSP00000388791
resolver
ensp
ENSP00000558503
resolver
genesymbol
ARFGAP3
resolver
genesymbol_syn
ARFGAP1
resolver
hgnc
HGNC:661
resolver
uniprot
E9PB03
resolver
uniprot
Q9BSC6
resolver
uniprot
Q9H9J0
resolver
uniprot
Q9NT10
resolver
uniprot
Q9NUP5
resolver
uniprot
Q9Y4V3
resolver
uniprot
Q9Y4V4
resolver
uniprot_entry
ARFG3_HUMAN
resolver
uniprot_sec
E9PB03
resolver
uniprot_sec
Q9BSC6
resolver
uniprot_sec
Q9H9J0
resolver
uniprot_sec
Q9NT10
resolver
uniprot_sec
Q9NUP5
resolver
uniprot_sec
Q9Y4V3
resolver
uniprot_sec
Q9Y4V4
resolver
activity_regulation
ACTIVITY REGULATION: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2). {ECO:0000269|PubMed:11172815}.
uniprot
proteins
amino_acid_sequence
MGDPSKQDILTIFKRLRSVPTNKVCFDCGAKNPSWASITYGVFLCIDCSGSHRSLGVHLSFIRSTELDSNWSWFQLRCMQVGGNASASSFFHQHGCSTNDTNAKYNSRAAQLYREKIKSLASQATRKHGTDLWLDSCVVPPLSPPPKEEDFFASHVSPEVSDTAWASAIAEPSSLTSRPVETTLENNEGGQEQGPSVEGLNVPTKATLEVSSIIKKKPNQAKKGLGAKKGSLGAQKLANTCFNEIEKQAQAADKMKEQEDLAKVVSKEESIVSSLRLAYKDLEIQMKKDEKMNISGKKNVDSDRLGMGFGNCRSVISHSVTSDMQTIEQESPIMAKPRKKYNDDSDDSYFTSSSSYFDEPVELRSSSFSSWDDSSDSYWKKETSKDTETVLKTTGYSDRPTARRKPDYEPVENTDEAQKKFGNVKAISSDMYFGRQSQADYETRARLERLSASSSISSADLFEEPRKQPAGNYSLSSVLPNAPDMAQFKQGVRSVAGKLSVFANGVVTSIQDRYGS
uniprot
proteins
function
FUNCTION: GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1), which is essential for COPI vesicle formation and retrograde transport between the Golgi and the endoplasmic reticulum (PubMed:11172815, PubMed:20858901). Hydrolysis of ARF1-bound GTP leads to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (PubMed:11172815, PubMed:20858901). Promotes the proper assembly of the COPI coat lattice, rather than just acting as a simple curvature-dependent GAP like ARFGAP1 (PubMed:20858901). {ECO:0000269|PubMed:11172815, ECO:0000269|PubMed:20858901}.
uniprot
proteins
mass_dalton
56928
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
10704287
uniprot
proteins
pubmed
11172815
uniprot
proteins
pubmed
12529303
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17760859
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20858901
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
516
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:17760859, ECO:0000269|PubMed:20858901}; Peripheral membrane protein {ECO:0000269|PubMed:17760859, ECO:0000269|PubMed:20858901}; Cytoplasmic side {ECO:0000269|PubMed:17760859}. Cytoplasm {ECO:0000269|PubMed:17760859}. Note=Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment. {ECO:0000269|PubMed:17760859}.
uniprot
proteins