TSEN15
entrez
116461
canonical
uniprot
Q8WW01
canonical
ensembl
ENSG00000198860
resolver
ensp
ENSP00000355299
resolver
ensp
ENSP00000402002
resolver
ensp
ENSP00000436996
resolver
ensp
ENSP00000493902
resolver
ensp
ENSP00000494932
resolver
enst
ENST00000361641
resolver
enst
ENST00000533373
resolver
enst
ENST00000643231
resolver
genesymbol
C1orf19
resolver
genesymbol
TSEN15
resolver
genesymbol_syn
C1orf19
resolver
genesymbol_syn
SEN15
resolver
hgnc
HGNC:16791
resolver
uniprot
A0A2R8YDU8
resolver
uniprot
A0A2U3TZM3
resolver
uniprot
B1ALV0
resolver
uniprot
B4DKP0
resolver
uniprot
E9PPN1
resolver
uniprot
Q9BZQ5
resolver
uniprot_entry
A0A2R8YDU8_HUMAN
resolver
uniprot_entry
A0A2U3TZM3_HUMAN
resolver
uniprot_entry
B1ALV0_HUMAN
resolver
uniprot_entry
E9PPN1_HUMAN
resolver
uniprot_entry
SEN15_HUMAN
resolver
uniprot_sec
B4DKP0
resolver
uniprot_sec
Q9BZQ5
resolver
amino_acid_sequence
MEERGDSEPTPGCSGLGPGGVRGFGDGGGAPSWAPEDAWMGTHPKYLEMMELDIGDATQVYVAFLVYLDLMESKSWHEVNCVGLPELQLICLVGTEIEGEGLQTVVPTPITASLSHNRIREILKASRKLQGDPDLPMSFTLAIVESDSTIVYYKLTDGFMLPDPQNISLRR
uniprot
proteins
disease_involvement
DISEASE: Pontocerebellar hypoplasia 2F (PCH2F) [MIM:617026]: A neurodevelopmental disorder characterized by progressive microcephaly, cognitive and motor delay, poor or absent speech, seizures, and spasticity. PCH2F inheritance is autosomal recessive. {ECO:0000269|PubMed:25558065, ECO:0000269|PubMed:27392077}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini (PubMed:15109492, PubMed:27392077). There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (PubMed:15109492). {ECO:0000269|PubMed:15109492, ECO:0000269|PubMed:27392077}.
uniprot
proteins
mass_dalton
18641
uniprot
proteins
protein_family
SEN15 family
uniprot
proteins
pubmed
11318611
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15109492
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17166513
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25558065
uniprot
proteins
pubmed
27392077
uniprot
proteins
sequence_length
171
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Nucleus, nucleolus {ECO:0000305}. Note=May be transiently localized in the nucleolus. {ECO:0000305}.
uniprot
proteins