CENPQ
entrez
55166
canonical
uniprot
Q7L2Z9
canonical
ensembl
ENSG00000031691
resolver
ensp
ENSP00000337289
resolver
ensp
ENSP00000538111
resolver
ensp
ENSP00000605163
resolver
ensp
ENSP00000605164
resolver
ensp
ENSP00000624422
resolver
ensp
ENSP00000624423
resolver
enst
ENST00000335783
resolver
enst
ENST00000868052
resolver
enst
ENST00000935104
resolver
enst
ENST00000935105
resolver
enst
ENST00000954363
resolver
enst
ENST00000954364
resolver
genesymbol
CENPQ
resolver
genesymbol_syn
C6orf139
resolver
hgnc
HGNC:21347
resolver
uniprot
A8KAF1
resolver
uniprot
Q6IN61
resolver
uniprot
Q9NVS5
resolver
uniprot_entry
CENPQ_HUMAN
resolver
uniprot_sec
A8KAF1
resolver
uniprot_sec
Q6IN61
resolver
uniprot_sec
Q9NVS5
resolver
amino_acid_sequence
MSGKANASKKNAQQLKRNPKRKKDNEEVVLSENKVRNTVKKNKNHLKDLSSEGQTKHTNLKHGKTAASKRKTWQPLSKSTRDHLQTMMESVIMTILSNSIKEKEEIQYHLNFLKKRLLQQCETLKVPPKKMEDLTNVSSLLNMERARDKANEEGLALLQEEIDKMVETTELMTGNIQSLKNKIQILASEVEEEEERVKQMHQINSSGVLSLPELSQKTLKAPTLQKEILALIPNQNALLKDLDILHNSSQMKSMSTFIEEAYKKLDAS
uniprot
proteins
function
FUNCTION: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (PubMed:16622420). Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores (PubMed:25395579). {ECO:0000269|PubMed:16622420, ECO:0000269|PubMed:25395579}.
uniprot
proteins
mass_dalton
30595
uniprot
proteins
mutagenesis
MUTAGEN 50; /note="S->A: Abolishes the recruitment CENPE to kinetochores but has no effect on recruitment of PLK1 to knetochores."; /evidence="ECO:0000269|PubMed:25395579"; MUTAGEN 50; /note="S->D: No loss of the recruitment CENPE to kinetochores."; /evidence="ECO:0000269|PubMed:25395579
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-50 is essential for CENPE recruitment to kinetochores and orderly chromosome congression. {ECO:0000269|PubMed:25395579}.
uniprot
proteins
protein_family
CENP-Q/OKP1 family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16622419
uniprot
proteins
pubmed
16622420
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25395579
uniprot
proteins
sequence_length
268
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16622420}. Chromosome, centromere {ECO:0000269|PubMed:16622420}. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
uniprot
proteins