Cyp4a10
entrez
50549
canonical
uniprot
P08516
canonical
ensembl
ENSRNOG00000009597
resolver
ensp
ENSRNOP00000012888
resolver
enst
ENSRNOT00000012888
resolver
genesymbol
Cyp4a10
resolver
genesymbol_syn
Cyp4a-1
resolver
genesymbol_syn
Cyp4a1
resolver
uniprot
Q5EBD8
resolver
uniprot_entry
CP4AA_RAT
resolver
uniprot_sec
Q5EBD8
resolver
amino_acid_sequence
MSVSALSSTRFTGSISGFLQVASVLGLLLLLVKAVQFYLQRQWLLKAFQQFPSPPFHWFFGHKQFQGDKELQQIMTCVENFPSAFPRWFWGSKAYLIVYDPDYMKVILGRSDPKANGVYRLLAPWIGYGLLLLNGQPWFQHRRMLTPAFHYDILKPYVKNMADSIRLMLDKWEQLAGQDSSIEIFQHISLMTLDTVMKCAFSHNGSVQVDGNYKSYIQAIGNLNDLFHSRVRNIFHQNDTIYNFSSNGHLFNRACQLAHDHTDGVIKLRKDQLQNAGELEKVKKKRRLDFLDILLLARMENGDSLSDKDLRAEVDTFMFEGHDTTASGVSWIFYALATHPEHQQRCREEVQSVLGDGSSITWDHLDQIPYTTMCIKEALRLYPPVPGIVRELSTSVTFPDGRSLPKGIQVTLSIYGLHHNPKVWPNPEVFDPSRFAPDSPRHSHSFLPFSGGARNCIGKQFAMSEMKVIVALTLLRFELLPDPTKVPIPLPRLVLKSKNGIYLYLKKLH
uniprot
proteins
ec_number
1.14.14.80
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of long-chain fatty acids (PubMed:10362749, PubMed:10620324, PubMed:3027069). Acts as a major omega-hydroxylase for dodecanoic (lauric) acid in liver (PubMed:3027069). In kidney, may play an important role in omega-hydroxylation of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) to 20-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure (PubMed:10362749, PubMed:10620324, PubMed:16212878). Also participates in the formation of anti-inflammatory hydroxyepoxyeicosatrienoic acids (HEETs) in kidney by converting 8,9-epoxyeicosatrienoic acid (EET) to 20,8,9-HEET, an activator of PPARA (PubMed:14742258). Displays substantially lower fatty acid omega-1 hydroxylase activity (PubMed:10362749, PubMed:10620324). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:10362749, PubMed:10620324, PubMed:3027069). {ECO:0000269|PubMed:10362749, ECO:0000269|PubMed:10620324, ECO:0000269|PubMed:14742258, ECO:0000269|PubMed:16212878, ECO:0000269|PubMed:3027069}.
uniprot
proteins
mass_dalton
58215
uniprot
proteins
mutagenesis
MUTAGEN 320; /note="E->A: Loss of heme binding."; /evidence="ECO:0000269|PubMed:11821421
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
10362749
uniprot
proteins
pubmed
10620324
uniprot
proteins
pubmed
11139583
uniprot
proteins
pubmed
11821421
uniprot
proteins
pubmed
14742258
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1567203
uniprot
proteins
pubmed
16212878
uniprot
proteins
pubmed
2766932
uniprot
proteins
pubmed
3027069
uniprot
proteins
pubmed
3410047
uniprot
proteins
sequence_length
509
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:3027069}; Multi-pass membrane protein {ECO:0000255}. Microsome membrane {ECO:0000269|PubMed:3027069}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 11..31; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 121..141; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins