Larp7
entrez
28036
canonical
uniprot
Q05CL8
canonical
ensembl
ENSMUSG00000027968
resolver
ensp
ENSMUSP00000029588
resolver
genesymbol
Larp7
resolver
genesymbol_syn
D3Wsu161e
resolver
uniprot
Q3TSC2
resolver
uniprot
Q8K2Y6
resolver
uniprot
Q8VDW3
resolver
uniprot
Q9CSI2
resolver
uniprot
Q9CSI9
resolver
uniprot
Q9CUQ5
resolver
uniprot_entry
LARP7_MOUSE
resolver
uniprot_sec
Q3TSC2
resolver
uniprot_sec
Q8K2Y6
resolver
uniprot_sec
Q8VDW3
resolver
uniprot_sec
Q9CSI2
resolver
uniprot_sec
Q9CSI9
resolver
uniprot_sec
Q9CUQ5
resolver
amino_acid_sequence
METENQKTMEESTKRKEEKKKRSRVKQVLADIAKQVDFWFGDANLHKDKFLREQIEKSRDGYVDISLLVSFNKMKKLTTDGKLIARALKSSSVVELDLEGTRIRRKKPLGERPKDEEERTVYVELLPKNVTHSWIERVFGKCGNVVYISIPHYKSTGDPKGFAFVEFETKEQAAKAIEFLNNPPEEAPRKPGIFPKTVKNKPIPSLRVAEEKKKKKKKKGRIKKEESVQAKESAVDSSSSGVCKATKRPRTASEGSEAETPEAPKQPAKKKKKRDKVEASSLPEARAGKRERCSAEDEDCLPPRPKAKKRAQKDGVGQAASEVSKESRDLEFCSTEEEKETDRKGDSLSKVKRKHKKKHKERHKMGEEVIPLRVLSKTEWMDLKKEYLALQKASMASLKKTISQIKLESEMETDCKAPTAGSGQECSTQEKVSAQGPQFVTGVIVKIVSGEPLPGRKQVKDILATISEVVYIDLLEGDTECHARFKTPEDAQAVMNAQTEIRKKHSWNLEVLSGDHEQRYWQKILVDRQAKLNQPREKKRGTEKLITKAEKIRLAKTQQASQHIRFSEYD
uniprot
proteins
function
FUNCTION: RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function (PubMed:32017896). Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II (By similarity). The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (By similarity). The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC) (By similarity). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA; on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex (By similarity). LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing (PubMed:32017896). Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes (PubMed:32017896). U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity (PubMed:32017896). Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif (By similarity). U6 snRNA processing is required for spermatogenesis (PubMed:32017896). {ECO:0000250|UniProtKB:Q4G0J3, ECO:0000269|PubMed:32017896}.
uniprot
proteins
mass_dalton
64802
uniprot
proteins
mutagenesis
MUTAGEN 38; /note="F->A: Reduced binding to U6 snRNA without affecting binding to 7SKRNA. Reduced 2'-O-methylation of U6 snRNAs."; /evidence="ECO:0000269|PubMed:32017896
uniprot
proteins
protein_family
LARP7 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22865833
uniprot
proteins
pubmed
23154982
uniprot
proteins
pubmed
32017896
uniprot
proteins
sequence_length
570
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:32017896}.
uniprot
proteins