Casp3
entrez
25402
canonical
uniprot
P55213
canonical
ensembl
ENSRNOG00000010475
resolver
ensembl
ENSRNOG00055011427
resolver
ensembl
ENSRNOG00060007399
resolver
ensembl
ENSRNOG00065015182
resolver
ensp
ENSRNOP00000014096
resolver
ensp
ENSRNOP00055015619
resolver
ensp
ENSRNOP00060009190
resolver
ensp
ENSRNOP00065019686
resolver
enst
ENSRNOT00000014095
resolver
enst
ENSRNOT00055019386
resolver
enst
ENSRNOT00060012174
resolver
enst
ENSRNOT00065025146
resolver
genesymbol
Casp3
resolver
genesymbol_syn
Cpp32
resolver
uniprot
P70543
resolver
uniprot
P97699
resolver
uniprot
Q62993
resolver
uniprot_entry
CASP3_RAT
resolver
uniprot_sec
P70543
resolver
uniprot_sec
P97699
resolver
uniprot_sec
Q62993
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by BIRC6; following inhibition of BIRC6-caspase binding by DIABLO/SMAC, BIRC6 is subjected to caspase cleavage, leading to an increase in active caspases. {ECO:0000250|UniProtKB:P42574}.
uniprot
proteins
amino_acid_sequence
MDNNETSVDSKSINNFETKTIHGSKSMDSGIYLDSSYKMDYPEMGLCIIINNKNFHKSTGMSARNGTDVDAANLRETFMALKYEVRNKNDLTREEIMELMDSVSKEDHSKRSSFVCVILSHGDEGVIFGTNGPVDLKKLTSFFRGDYCRSLTGKPKLFIIQACRGTELDCGIETDSGTDDDMACQKIPVEADFLYAYSTAPGYYSWRNSRDGSWFIQSLCAMLKLYAHKLEFMHILTRVNRKVATEFESFSLDATFHAKKQIPCIVSMLTKELYFYH
uniprot
proteins
ec_number
3.4.22.56
uniprot
proteins
function
FUNCTION: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis, it proteolytically cleaves poly(ADP-ribose) polymerase PARP1 at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9 (CASP6, CASP7 and CASP9, respectively). Cleaves and inactivates interleukin-18 (IL18). Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Also involved in axon pruning during brain development (By similarity). Cleaves DSG2 in response to apoptosis resulting in a loss of full length DSG2 at desmosome cell junctions and subsequent loss of cell-cell adhesion (By similarity). Also cleaves JUP in response to apoptosis (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes (By similarity). Cleaves and inhibits serine/threonine-protein kinase AKT1 in response to oxidative stress. Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction. Also involved in pyroptosis by mediating cleavage and activation of gasdermin-E (GSDME) (By similarity). Cleaves XRCC4 and phospholipid scramblase proteins XKR4, XKR8 and XKR9, leading to promote phosphatidylserine exposure on apoptotic cell surface (By similarity). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (By similarity). {ECO:0000250|UniProtKB:P42574, ECO:0000250|UniProtKB:P70677}.
uniprot
proteins
mass_dalton
31492
uniprot
proteins
post_translational_modification
PTM: Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa. {ECO:0000250|UniProtKB:P42574}.; PTM: S-nitrosylated on its catalytic site cysteine in unstimulated cell lines and denitrosylated upon activation of the Fas apoptotic pathway, associated with an increase in intracellular caspase activity. Fas therefore activates caspase-3 not only by inducing the cleavage of the caspase zymogen to its active subunits, but also by stimulating the denitrosylation of its active site thiol. {ECO:0000250|UniProtKB:P42574}.; PTM: Ubiquitinated by BIRC6; this activity is inhibited by DIABLO/SMAC. {ECO:0000250|UniProtKB:P42574}.
uniprot
proteins
protein_family
Peptidase C14A family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7588240
uniprot
proteins
pubmed
8761296
uniprot
proteins
pubmed
9030616
uniprot
proteins
sequence_length
277
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P42574}.
uniprot
proteins