SEC61G
entrez
23480
canonical
uniprot
P60059
canonical
ensembl
ENSG00000132432
resolver
ensp
ENSP00000341538
resolver
ensp
ENSP00000378906
resolver
ensp
ENSP00000388337
resolver
ensp
ENSP00000409884
resolver
ensp
ENSP00000543672
resolver
ensp
ENSP00000543673
resolver
ensp
ENSP00000543674
resolver
ensp
ENSP00000543675
resolver
ensp
ENSP00000586432
resolver
ensp
ENSP00000586433
resolver
ensp
ENSP00000586434
resolver
ensp
ENSP00000586435
resolver
ensp
ENSP00000586436
resolver
ensp
ENSP00000586437
resolver
ensp
ENSP00000586438
resolver
ensp
ENSP00000586439
resolver
ensp
ENSP00000586440
resolver
ensp
ENSP00000586441
resolver
ensp
ENSP00000586442
resolver
ensp
ENSP00000586443
resolver
ensp
ENSP00000616062
resolver
enst
ENST00000352861
resolver
enst
ENST00000395535
resolver
enst
ENST00000415949
resolver
enst
ENST00000450622
resolver
enst
ENST00000873613
resolver
enst
ENST00000873614
resolver
enst
ENST00000873615
resolver
enst
ENST00000873616
resolver
enst
ENST00000916373
resolver
enst
ENST00000916374
resolver
enst
ENST00000916375
resolver
enst
ENST00000916376
resolver
enst
ENST00000916377
resolver
enst
ENST00000916378
resolver
enst
ENST00000916379
resolver
enst
ENST00000916380
resolver
enst
ENST00000916381
resolver
enst
ENST00000916382
resolver
enst
ENST00000916383
resolver
enst
ENST00000916384
resolver
enst
ENST00000946003
resolver
genesymbol
SEC61G
resolver
hgnc
HGNC:18277
resolver
uniprot
B2R4J0
resolver
uniprot
P38384
resolver
uniprot
Q6IB25
resolver
uniprot_entry
SC61G_HUMAN
resolver
uniprot_sec
B2R4J0
resolver
uniprot_sec
P38384
resolver
uniprot_sec
Q6IB25
resolver
amino_acid_sequence
MDQVMQFVEPSRQFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIHIPINNIIVGG
uniprot
proteins
function
FUNCTION: Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER) (By similarity). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides (By similarity). The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex (PubMed:32820719, PubMed:36261522). The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (By similarity). {ECO:0000250|UniProtKB:P60058, ECO:0000250|UniProtKB:P61619, ECO:0000269|PubMed:32820719, ECO:0000269|PubMed:36261522}.
uniprot
proteins
mass_dalton
7741
uniprot
proteins
protein_family
SecE/SEC61-gamma family
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
30550790
uniprot
proteins
pubmed
32820719
uniprot
proteins
pubmed
36261522
uniprot
proteins
pubmed
36697828
uniprot
proteins
sequence_length
68
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:36261522}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 33..61; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins