Mt-atp6
entrez
26197
canonical
uniprot
P05504
canonical
genesymbol
Mt-atp6
resolver
genesymbol_syn
ATP6
resolver
genesymbol_syn
Atp6
resolver
genesymbol_syn
Atpase6
resolver
genesymbol_syn
Mtatp6
resolver
genesymbol_syn
mt-Co3
resolver
genesymbol_syn
mt-Nd4l
resolver
uniprot
Q8HIC7
resolver
uniprot
Q9T2E9
resolver
uniprot_entry
ATP6_RAT
resolver
uniprot_entry
Q8HIC7_RAT
resolver
uniprot_sec
Q9T2E9
resolver
amino_acid_sequence
MNENLFASFITPTMMGLPIVVTIIMFPSILFPSSERLISNRLHSFQHWLIKLIIKQMMLIHTPKGRTWALMIVSLIMFIGSTNLLGLLPHTFTPTTQLSMNLSMAIPLWAGAVILGFRHKLKNSLAHFLPQGTPISLIPMLIIIETISLFIQPMALAVRLTANITAGHLLMHLIGGATLVLMDISPPTATITFIILLLLTVLEFAVALIQAYVFTLLVSLYLHDNT
uniprot
proteins
function
FUNCTION: Subunit a, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. With the subunit c (ATP5MC1), forms the proton-conducting channel in the F(0) domain, that contains two crucial half-channels (inlet and outlet) that facilitate proton movement from the mitochondrial intermembrane space (IMS) into the matrix. Protons are taken up via the inlet half-channel and released through the outlet half-channel, following a Grotthuss mechanism. {ECO:0000250|UniProtKB:P00846}.
uniprot
proteins
mass_dalton
25076
uniprot
proteins
protein_family
ATPase A chain family
uniprot
proteins
pubmed
11163232
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
24185961
uniprot
proteins
pubmed
2504926
uniprot
proteins
pubmed
8529844
uniprot
proteins
sequence_length
226
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 6..26; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 68..88; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 97..117; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 138..158; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 164..184; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 189..209; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins