Adra2b
entrez
11552
canonical
uniprot
P30545
canonical
ensembl
ENSMUSG00000058620
resolver
ensp
ENSMUSP00000071798
resolver
ensp
ENSMUSP00000100539
resolver
enst
ENSMUST00000071902
resolver
enst
ENSMUST00000104934
resolver
genesymbol
Adra2b
resolver
uniprot
F6SVH1
resolver
uniprot
F8VQ23
resolver
uniprot
Q925K6
resolver
uniprot_entry
ADA2B_MOUSE
resolver
uniprot_entry
F6SVH1_MOUSE
resolver
uniprot_entry
Q925K6_MOUSE
resolver
uniprot_sec
F8VQ23
resolver
amino_acid_sequence
MSGPAMVHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQRPEPHGLPQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSHCRGLGAKRGSGEGESKKPHPAAGGVPASAKVPTLVSPLSSVGEANGHPKPPREKEEGETPEDPEARALPPNWSALPRSVQDQKKGTSGATAEKGAEEDEEEVEECEPQTLPASPASVFNPPLQQPQTSRVLATLRGQVLLSKNVGVASGQWWRRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRQWTQTGW
uniprot
proteins
function
FUNCTION: Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression (PubMed:1354956). ADRA2B physiological agonists includes norepinephrine and epinephrine (PubMed:1354956). {ECO:0000269|PubMed:1354956}.
uniprot
proteins
mass_dalton
50443
uniprot
proteins
protein_family
ADRA2B sub-subfamily
uniprot
proteins
protein_family
Adrenergic receptor subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
1336396
uniprot
proteins
pubmed
1354956
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
453
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P18089}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P18089}. Note=Interaction with RAB26, GGA1, GGA2 and GGA3 mediates transport from the Golgi to the cell membrane. {ECO:0000250|UniProtKB:P18089}.
uniprot
proteins
transmembrane_region
TRANSMEM 18..40; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P18089"; TRANSMEM 54..79; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P18089"; TRANSMEM 91..113; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P18089"; TRANSMEM 135..153; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P18089"; TRANSMEM 176..198; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P18089"; TRANSMEM 376..396; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P18089"; TRANSMEM 411..431; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P18089
uniprot
proteins