Ass1
entrez
11898
canonical
uniprot
P16460
canonical
ensembl
ENSMUSG00000076441
resolver
ensp
ENSMUSP00000099904
resolver
enst
ENSMUST00000102840
resolver
genesymbol
Ass1
resolver
genesymbol_syn
Ass
resolver
uniprot
Q3UJ34
resolver
uniprot_entry
ASSY_MOUSE
resolver
uniprot_entry
Q3UJ34_MOUSE
resolver
amino_acid_sequence
MSSKGSVVLAYSGGLDTSCILVWLKEQGYDVIAYLANIGQKEDFEEARKKALKLGAKKVFIEDVSKEFVEEFIWPAVQSSALYEDRYLLGTSLARPCIARRQVEIAQREGAKYVSHGATGKGNDQVRFELTCYSLAPQIKVIAPWRMPEFYNRFKGRNDLMEYAKQHGIPIPVTPKSPWSMDENLMHISYEAGILENPKNQAPPGLYTKTQDPAKAPNSPDVLEIEFKKGVPVKVTNIKDGTTRTTSLELFMYLNEVAGKHGVGRIDIVENRFIGMKSRGIYETPAGTILYHAHLDIEAFTMDREVRKIKQGLGLKFAELVYTGFWHSPECEFVRHCIQKSQERVEGKVQVSVFKGQVYILGRESPLSLYNEELVSMNVQGDYEPIDATGFININSLRLKEYHRLQSKVTAK
uniprot
proteins
ec_number
6.3.4.5
uniprot
proteins
function
FUNCTION: One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues. {ECO:0000250|UniProtKB:P00966}.
uniprot
proteins
mass_dalton
46584
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. {ECO:0000250|UniProtKB:P00966}.; PATHWAY: Nitrogen metabolism; urea cycle; (N(omega)-L-arginino)succinate from L-aspartate and L-citrulline: step 1/1. {ECO:0000250|UniProtKB:P00966}.
uniprot
proteins
post_translational_modification
PTM: Acetylated by CLOCK in a circadian manner which negatively regulates its enzyme activity. Deacetylated by histone deacetylases. {ECO:0000269|PubMed:28985504}.
uniprot
proteins
protein_family
Argininosuccinate synthase family
uniprot
proteins
protein_family
Type 1 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1708740
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22081021
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
28985504
uniprot
proteins
sequence_length
412
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P00966}.
uniprot
proteins