Otop3
entrez
69602
canonical
uniprot
Q80UF9
canonical
ensembl
ENSMUSG00000018862
resolver
ensp
ENSMUSP00000019006
resolver
ensp
ENSMUSP00000102153
resolver
enst
ENSMUST00000019006
resolver
genesymbol
Otop3
resolver
uniprot
A2A6S7
resolver
uniprot
B9EKA4
resolver
uniprot
F8VQ32
resolver
uniprot
Q7M736
resolver
uniprot
Q810B4
resolver
uniprot
Q9D7E9
resolver
uniprot_entry
F8VQ32_MOUSE
resolver
uniprot_entry
OTOP3_MOUSE
resolver
uniprot_entry
Q9D7E9_MOUSE
resolver
uniprot_sec
A2A6S7
resolver
uniprot_sec
B9EKA4
resolver
uniprot_sec
Q7M736
resolver
uniprot_sec
Q810B4
resolver
activity_regulation
ACTIVITY REGULATION: Activated by extracellular acidification (PubMed:37023615). Activated by Zn(2+) under non-acidic conditions (PubMed:37023615, PubMed:37053086). {ECO:0000269|PubMed:37023615, ECO:0000269|PubMed:37053086}.
uniprot
proteins
amino_acid_sequence
MASQTSAPAEPAPMPSPEAKTTEGASSYDQADMETKHAGSPCPPKQKSWLARHFSLLLRRDRQAQKAGQLFSGLLALNVVFLGGAFICSMIFNKVSVTLGDVWILLAALKVLSLLWLLYYTVGTTRKPHAVLYRDPHAGPIWVRGSLVLFGSCTVCLNIFRMGYDVSHIHCKSEVELIFPAIEIVFMIIQTWVLWRHCKDCVQVQTNFTRCGLMLTLATNLLMWVLAVTNDSMHREIEAELDALMEKFSGNGTNTCMCLNTTVCEVFRKGYLMLYPFSTEYCLICCAVLFVMWKNVSRSLAAHTGAHPNRSPFRLHGTIFGPLLGLLALVAGVCVFVLFQIEASGPDIARQYFTLYYAFYVAVLPTMSLACLAGTAIHGLEERELDTLKNPTRSLDVVLLMGAALGQMGIAYFSIVAIVATQPHELLNQLILAYSLLLILQHITQNLFIIEGLHRRPLWEPAVSGVMEKQDVELPRRGSLRELGQDLRRASRAYIHSFSHLNWKRRMLKEISLFLILCNITLWMMPAFGIHPEFENGLEKDFYGYRTWFTIVNFGLPLGVFYRMHSVGGLVEVYLGA
uniprot
proteins
function
FUNCTION: Proton-selective channel gated by extracellular protons. {ECO:0000269|PubMed:29371428, ECO:0000269|PubMed:37023615, ECO:0000269|PubMed:37053086}.
uniprot
proteins
mass_dalton
64743
uniprot
proteins
mutagenesis
MUTAGEN 234; /note="H->A: Reduced efficacy of Zn(2+) to potentiate proton channel activity."; /evidence="ECO:0000269|PubMed:37053086"; MUTAGEN 238; /note="E->A: Reduced efficacy of Zn(2+) to potentiate proton channel activity."; /evidence="ECO:0000269|PubMed:37053086"; MUTAGEN 531; /note="H->R,A: Eliminated the ability of Zn(2+) to potentiate proton channel activity."; /evidence="ECO:0000269|PubMed:37053086"; MUTAGEN 535; /note="E->A: Reduced the ability of Zn(2+) to potentiate proton channel activity."; /evidence="ECO:0000269|PubMed:37053086
uniprot
proteins
protein_family
Otopetrin family
uniprot
proteins
pubmed
12651873
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
29371428
uniprot
proteins
pubmed
37023615
uniprot
proteins
pubmed
37053086
uniprot
proteins
sequence_length
577
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:37023615}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A9JTM7}.
uniprot
proteins
transmembrane_region
TRANSMEM 70..90; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:A9JTM7"; TRANSMEM 101..124; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:A9JTM7"; TRANSMEM 141..162; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:A9JTM7"; TRANSMEM 175..198; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:A9JTM7"; TRANSMEM 207..229; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:A9JTM7"; TRANSMEM 277..293; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:A9JTM7"; TRANSMEM 320..339; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:A9JTM7"; TRANSMEM 354..376; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:A9JTM7"; TRANSMEM 395..416; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:A9JTM7"; TRANSMEM 428..450; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:A9JTM7"; TRANSMEM 511..528; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:A9JTM7"; TRANSMEM 548..570; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:A9JTM7
uniprot
proteins