RRP9
entrez
9136
canonical
uniprot
O43818
canonical
ensembl
ENSG00000114767
resolver
ensp
ENSP00000232888
resolver
enst
ENST00000232888
resolver
genesymbol
RRP9
resolver
genesymbol_syn
RNU3IP2
resolver
genesymbol_syn
U355K
resolver
hgnc
HGNC:16829
resolver
uniprot
B2R996
resolver
uniprot
Q8IZ30
resolver
uniprot_entry
U3IP2_HUMAN
resolver
uniprot_sec
B2R996
resolver
uniprot_sec
Q8IZ30
resolver
amino_acid_sequence
MSATAAARKRGKPASGAGAGAGAGKRRRKADSAGDRGKSKGGGKMNEEISSDSESESLAPRKPEEEEEEELEETAQEKKLRLAKLYLEQLRQQEEEKAEARAFEEDQVAGRLKEDVLEQRGRLQKLVAKEIQAPASADIRVLRGHQLSITCLVVTPDDSAIFSAAKDCSIIKWSVESGRKLHVIPRAKKGAEGKPPGHSSHVLCMAISSDGKYLASGDRSKLILIWEAQSCQHLYTFTGHRDAVSGLAFRRGTHQLYSTSHDRSVKVWNVAENSYVETLFGHQDAVAALDALSRECCVTAGGRDGTVRVWKIPEESQLVFYGHQGSIDCIHLINEEHMVSGADDGSVALWGLSKKRPLALQREAHGLRGEPGLEQPFWISSVAALLNTDLVATGSHSSCVRLWQCGEGFRQLDLLCDIPLVGFINSLKFSSSGDFLVAGVGQEHRLGRWWRIKEARNSVCIIPLRRVPVPPAAGS
uniprot
proteins
function
FUNCTION: Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA (pre-rRNA) (PubMed:26867678). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). {ECO:0000269|PubMed:26867678, ECO:0000269|PubMed:34516797}.
uniprot
proteins
mass_dalton
51841
uniprot
proteins
mutagenesis
MUTAGEN 12; /note="K->Q: Mimics acetylation, leading to impaired rRNA processing; when associated with Q-25."; /evidence="ECO:0000269|PubMed:26867678"; MUTAGEN 12; /note="K->R: Impaired acetylation, leading to promote rRNA processing; when associated with R-25."; /evidence="ECO:0000269|PubMed:26867678"; MUTAGEN 25; /note="K->Q: Mimics acetylation, leading to impaired rRNA processing; when associated with Q-12."; /evidence="ECO:0000269|PubMed:26867678"; MUTAGEN 25; /note="K->R: Impaired acetylation, leading to promote rRNA processing; when associated with R-12."; /evidence="ECO:0000269|PubMed:26867678
uniprot
proteins
post_translational_modification
PTM: Acetylation at Lys-12 and Lys-25 by KAT2B/PCAF under stress impairs pre-rRNA processing (PubMed:26867678). Deacetylation by SIRT7 enhances RRP9-binding to U3 snoRNA, which is a prerequisite for pre-rRNA processing (PubMed:26867678). {ECO:0000269|PubMed:26867678}.
uniprot
proteins
protein_family
WD repeat RRP9 family
uniprot
proteins
pubmed
10982864
uniprot
proteins
pubmed
12381732
uniprot
proteins
pubmed
12429849
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
26867678
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
34516797
uniprot
proteins
pubmed
9418896
uniprot
proteins
sequence_length
475
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:26867678, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:9418896}.
uniprot
proteins