RABGEF1
entrez
27342
canonical
uniprot
Q9UJ41
canonical
ensembl
ENSG00000154710
resolver
ensp
ENSP00000284957
resolver
ensp
ENSP00000403429
resolver
ensp
ENSP00000415815
resolver
ensp
ENSP00000571913
resolver
ensp
ENSP00000571914
resolver
ensp
ENSP00000571915
resolver
ensp
ENSP00000571917
resolver
ensp
ENSP00000571919
resolver
ensp
ENSP00000571921
resolver
ensp
ENSP00000571923
resolver
ensp
ENSP00000571924
resolver
ensp
ENSP00000571925
resolver
ensp
ENSP00000571926
resolver
ensp
ENSP00000571930
resolver
ensp
ENSP00000583922
resolver
ensp
ENSP00000583924
resolver
ensp
ENSP00000631427
resolver
ensp
ENSP00000631431
resolver
ensp
ENSP00000646739
resolver
ensp
ENSP00000792317
resolver
genesymbol
RABGEF1
resolver
genesymbol_syn
RABEX5
resolver
hgnc
HGNC:17676
resolver
uniprot
A8K3R3
resolver
uniprot
B3KMF1
resolver
uniprot
B4DZM7
resolver
uniprot
Q3HKR2
resolver
uniprot
Q3HKR3
resolver
uniprot
Q53FG0
resolver
uniprot_entry
A8K3R3_HUMAN
resolver
uniprot_entry
B3KMF1_HUMAN
resolver
uniprot_entry
RABX5_HUMAN
resolver
uniprot_sec
B4DZM7
resolver
uniprot_sec
Q3HKR2
resolver
uniprot_sec
Q3HKR3
resolver
uniprot_sec
Q53FG0
resolver
amino_acid_sequence
MSLKSERRGIHVDQSDLLCKKGCGYYGNPAWQGFCSKCWREEYHKARQKQIQEDWELAERLQREEEEAFASSQSSQGAQSLTFSKFEEKKTNEKTRKVTTVKKFFSASSRVGSKKEIQEAKAPSPSINRQTSIETDRVSKEFIEFLKTFHKTGQEIYKQTKLFLEGMHYKRDLSIEEQSECAQDFYHNVAERMQTRGKVPPERVEKIMDQIEKYIMTRLYKYVFCPETTDDEKKDLAIQKRIRALRWVTPQMLCVPVNEDIPEVSDMVVKAITDIIEMDSKRVPRDKLACITKCSKHIFNAIKITKNEPASADDFLPTLIYIVLKGNPPRLQSNIQYITRFCNPSRLMTGEDGYYFTNLCCAVAFIEKLDAQSLNLSQEDFDRYMSGQTSPRKQEAESWSPDACLGVKQMYKNLDLLSQLNERQERIMNEAKKLEKDLIDWTDGIAREVQDIVEKYPLEIKPPNQPLAAIDSENVENDKLPPPLQPQVYAG
uniprot
proteins
function
FUNCTION: Acts as a guanine-nucleotide releasing factor (GEF) for RAB5A by promoting the conversion of inactive RAB-GDP to the active form RAB-GTP (PubMed:15339665, PubMed:9323142). Forms a complex with RABEP1 that acts as Rab4/Rab5 effector regulating endosome fusion. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes (PubMed:11452015, PubMed:9323142). Also functions as a ubiquitin ligase (By similarity). {ECO:0000250|UniProtKB:O18973, ECO:0000269|PubMed:11452015, ECO:0000269|PubMed:15339665, ECO:0000269|PubMed:9323142}.
uniprot
proteins
mass_dalton
56891
uniprot
proteins
mutagenesis
MUTAGEN 58; /note="A->G: Reduces affinity for ubiquitin 3-fold."; /evidence="ECO:0000269|PubMed:16499958"; MUTAGEN 313; /note="D->A: Strongly reduced activity."; /evidence="ECO:0000269|PubMed:15339665"; MUTAGEN 317; /note="P->A: Strongly reduced activity."; /evidence="ECO:0000269|PubMed:15339665"; MUTAGEN 354; /note="Y->A: Strongly reduced activity."; /evidence="ECO:0000269|PubMed:15339665"; MUTAGEN 357; /note="T->A: Strongly reduced activity."; /evidence="ECO:0000269|PubMed:15339665
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated.
uniprot
proteins
pubmed
11098082
uniprot
proteins
pubmed
11452015
uniprot
proteins
pubmed
12505986
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15339665
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16499958
uniprot
proteins
pubmed
17450153
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9323142
uniprot
proteins
sequence_length
491
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12505986}. Early endosome {ECO:0000269|PubMed:12505986}. Recycling endosome {ECO:0000269|PubMed:12505986}.
uniprot
proteins