Hrh2
entrez
15466
canonical
uniprot
P97292
canonical
ensembl
ENSMUSG00000034987
resolver
ensp
ENSMUSP00000038170
resolver
ensp
ENSMUSP00000148117
resolver
enst
ENSMUST00000038101
resolver
enst
ENSMUST00000209846
resolver
genesymbol
Hrh2
resolver
uniprot
A0A1B0GSX9
resolver
uniprot
Q9D282
resolver
uniprot_entry
A0A1B0GSX9_MOUSE
resolver
uniprot_entry
HRH2_MOUSE
resolver
uniprot_sec
Q9D282
resolver
amino_acid_sequence
MEPNGTVHSCCLDSIALKVTISVVLTTLIFITVAGNVVVCLAVSLNRRLRSLTNCFIVSLAATDLLLGLLVMPFSAIYQLSFKWSFGQVFCNIYTSLDVMLCTASILNLFMISLDRYCAVTDPLRYPVLVTPVRVAISLVFIWVISITLSFLSIHLGWNSRNGTRGGNDTFKCKVQVNEVYGLVDGMVTFYLPLLIMCVTYYRIFKIAREQAKRINHISSWKAATIREHKATVTLAAVMGAFIVCWFPYFTAFVYRGLRGDDAVNEVVEGIVLWLGYANSALNPILYATLNRDFRMAYQQLFHCKLASHNSHKTSLRLNNSLLSRSQSREGRWQEEKPLKLQVWSGTELTHPQGSPVRTRLSHSSCLLSLSLLSFIWKLGTWIHHRRPFQPSLHISA
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for histamine, primarily mediating gastric acid secretion. Predominantly expressed in the gastric mucosa, couples to G(s) G alpha proteins upon histamine binding, leading to activation of adenylate cyclase and increased intracellular cyclic AMP (cAMP) levels (By similarity). This signaling cascade stimulates parietal cells to secrete hydrochloric acid, playing a key role in digestive physiology (PubMed:10862789). Also expressed in other tissues, including the heart and central nervous system, where it may contribute to cardiac stimulation and modulate neurotransmitter release (PubMed:12729842). {ECO:0000250|UniProtKB:P25021, ECO:0000269|PubMed:10862789, ECO:0000269|PubMed:12729842}.
uniprot
proteins
mass_dalton
44794
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10862789
uniprot
proteins
pubmed
12729842
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
8938453
uniprot
proteins
sequence_length
397
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 21..44; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P25021"; TRANSMEM 54..75; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P25021"; TRANSMEM 92..114; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P25021"; TRANSMEM 134..156; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P25021"; TRANSMEM 174..201; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P25021"; TRANSMEM 232..258; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P25021"; TRANSMEM 268..290; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P25021
uniprot
proteins