NINJ2
entrez
4815
canonical
uniprot
Q9NZG7
canonical
ensembl
ENSG00000171840
resolver
ensp
ENSP00000307552
resolver
ensp
ENSP00000380435
resolver
ensp
ENSP00000438831
resolver
ensp
ENSP00000499548
resolver
ensp
ENSP00000527908
resolver
enst
ENST00000305108
resolver
enst
ENST00000397265
resolver
enst
ENST00000542920
resolver
enst
ENST00000662884
resolver
enst
ENST00000857849
resolver
genesymbol
NINJ2
resolver
hgnc
HGNC:7825
resolver
uniprot
A0A590UJR9
resolver
uniprot
B4DJC1
resolver
uniprot
F5H3L1
resolver
uniprot
F8WBZ3
resolver
uniprot_entry
A0A590UJR9_HUMAN
resolver
uniprot_entry
B4DJC1_HUMAN
resolver
uniprot_entry
F5H3L1_HUMAN
resolver
uniprot_entry
F8WBZ3_HUMAN
resolver
uniprot_entry
NINJ2_HUMAN
resolver
amino_acid_sequence
MESARENIDLQPGSSDPRSQPINLNHYATKKSVAESMLDVALFMSNAMRLKAVLEQGPSSHYYTTLVTLISLSLLLQVVIGVLLVVIARLNLNEVEKQWRLNQLNNAATILVFFTVVINVFITAFGAHKTGFLAARASRNPL
uniprot
proteins
function
FUNCTION: Its role in unclear (PubMed:33472215, PubMed:38614101, PubMed:39667936). In contrast to NINJ1 paralog, does not mediate plasma membrane rupture (cytolysis) downstream of necroptotic and pyroptotic programmed cell death (PubMed:33472215, PubMed:38614101, PubMed:39667936). While it is able to oligomerize and form filaments, filaments are curved toward the intracellular space, preventing circularization to mediate plasma membrane rupture (PubMed:39667936). May act as a homophilic transmembrane adhesion molecule involved in nerve regeneration (PubMed:10627596). Promotes axonal growth (PubMed:10627596). {ECO:0000269|PubMed:10627596, ECO:0000269|PubMed:33472215, ECO:0000269|PubMed:38614101, ECO:0000269|PubMed:39667936}.
uniprot
proteins
mass_dalton
15680
uniprot
proteins
mutagenesis
MUTAGEN 62..68; /note="YYTTLVT->FYVPLVV: In mutant M9 + W99A; induces ability to mediate plama membrane rupture; when associated with G-79, F-86, A-99, F-103, L-107 and G-110."; /evidence="ECO:0000269|PubMed:39667936"; MUTAGEN 79; /note="V->G: In mutant M9 + W99A; induces ability to mediate plama membrane rupture; when associated with 62-F--V-68, F-86, A-99, F-103, L-107 and G-110."; /evidence="ECO:0000269|PubMed:39667936"; MUTAGEN 86; /note="V->F: Promotes slight ability to mediate plasma membrane rupture. In mutant M9 + W99A; induces ability to mediate plama membrane rupture; when associated with 62-F--V-68, G-79, A-99, F-103, L-107 and G-110."; /evidence="ECO:0000269|PubMed:38614101, ECO:0000269|PubMed:39667936"; MUTAGEN 99; /note="W->A: In mutant M9 + W99A; induces ability to mediate plama membrane rupture; when associated with 62-F--V-68, G-79, F-86, F-103, L-107 and G-110."; /evidence="ECO:0000269|PubMed:39667936"; MUTAGEN 103; /note="Q->F: Promotes ability to mediate plasma membrane rupture. In mutant M9 + W99A; induces ability to mediate plama membrane rupture; when associated with 62-F--V-68, G-79, F-86, A-99, L-107 and G-110."; /evidence="ECO:0000269|PubMed:38614101, ECO:0000269|PubMed:39667936"; MUTAGEN 107; /note="A->L: In mutant M9 + W99A; induces ability to mediate plama membrane rupture; when associated with 62-F--V-68, G-79, F-86, A-99, F-103 and G-110."; /evidence="ECO:0000269|PubMed:39667936"; MUTAGEN 110; /note="I->G: Promotes ability to mediate plasma membrane rupture. In mutant M9 + W99A; induces ability to mediate plama membrane rupture; when associated with 62-F--V-68, G-79, F-86, A-99, F-103 and L-107."; /evidence="ECO:0000269|PubMed:38614101, ECO:0000269|PubMed:39667936"; MUTAGEN 114; /note="F->I: Promotes ability to mediate plasma membrane rupture."; /evidence="ECO:0000269|PubMed:38614101
uniprot
proteins
protein_family
Ninjurin family
uniprot
proteins
pubmed
10627596
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
33472215
uniprot
proteins
pubmed
38614101
uniprot
proteins
pubmed
39667936
uniprot
proteins
sequence_length
142
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:39667936, ECO:0000305|PubMed:10627596, ECO:0000305|PubMed:38614101}; Multi-pass membrane protein {ECO:0000269|PubMed:39667936}.
uniprot
proteins
transmembrane_region
TRANSMEM 61..92; /note="Helical; Name=Helix alpha3"; /evidence="ECO:0000269|PubMed:39667936, ECO:0007744|PDB:8SZB"; TRANSMEM 97..126; /note="Helical;Name=Helix alpha4"; /evidence="ECO:0000269|PubMed:39667936, ECO:0007744|PDB:8SZB
uniprot
proteins