NAT1
entrez
9
canonical
uniprot
P18440
canonical
ensembl
ENSG00000171428
resolver
ensp
ENSP00000307218
resolver
ensp
ENSP00000428270
resolver
ensp
ENSP00000429341
resolver
ensp
ENSP00000429407
resolver
ensp
ENSP00000443194
resolver
ensp
ENSP00000573059
resolver
ensp
ENSP00000573060
resolver
ensp
ENSP00000573061
resolver
ensp
ENSP00000573062
resolver
ensp
ENSP00000573063
resolver
ensp
ENSP00000573064
resolver
ensp
ENSP00000573065
resolver
ensp
ENSP00000573066
resolver
ensp
ENSP00000573067
resolver
ensp
ENSP00000573068
resolver
ensp
ENSP00000608806
resolver
ensp
ENSP00000608807
resolver
ensp
ENSP00000608808
resolver
enst
ENST00000307719
resolver
enst
ENST00000517492
resolver
enst
ENST00000518029
resolver
enst
ENST00000520546
resolver
enst
ENST00000545197
resolver
enst
ENST00000903000
resolver
enst
ENST00000903001
resolver
enst
ENST00000903002
resolver
enst
ENST00000903003
resolver
enst
ENST00000903004
resolver
enst
ENST00000903005
resolver
enst
ENST00000903006
resolver
enst
ENST00000903007
resolver
enst
ENST00000903008
resolver
enst
ENST00000903009
resolver
enst
ENST00000938747
resolver
enst
ENST00000938748
resolver
enst
ENST00000938749
resolver
genesymbol
NAT1
resolver
genesymbol_syn
AAC1
resolver
hgnc
HGNC:7645
resolver
uniprot
A8K4E7
resolver
uniprot
F5H5R8
resolver
uniprot
O15159
resolver
uniprot
O15300
resolver
uniprot
Q400J6
resolver
uniprot
Q546N1
resolver
uniprot
Q96TE9
resolver
uniprot_entry
ARY1_HUMAN
resolver
uniprot_entry
F5H5R8_HUMAN
resolver
uniprot_entry
Q400J6_HUMAN
resolver
uniprot_sec
A8K4E7
resolver
uniprot_sec
O15159
resolver
uniprot_sec
O15300
resolver
uniprot_sec
Q546N1
resolver
uniprot_sec
Q96TE9
resolver
activity_regulation
ACTIVITY REGULATION: N-acetylation activity is inhibited by phenylglyoxal hydrate (PG); the inactivation is time- and PG concentration- dependent. {ECO:0000269|PubMed:9173883}.
uniprot
proteins
amino_acid_sequence
MDIEAYLERIGYKKSRNKLDLETLTDILQHQIRAVPFENLNIHCGDAMDLGLEAIFDQVVRRNRGGWCLQVNHLLYWALTTIGFETTMLGGYVYSTPAKKYSTGMIHLLLQVTIDGRNYIVDAGFGRSYQMWQPLELISGKDQPQVPCVFRLTEENGFWYLDQIRREQYIPNEEFLHSDLLEDSKYRKIYSFTLKPRTIEDFESMNTYLQTSPSSVFTSKSFCSLQTPDGVHCLVGFTLTHRRFNYKDNTDLIEFKTLSEEEIEKVLKNIFNISLQRKLVPKHGDRFFTI
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
ec_number
2.3.1.118
uniprot
proteins
ec_number
2.3.1.5
uniprot
proteins
function
FUNCTION: Xenobiotic-metabolizing enzyme that catalyzes both N-acetylation (usually detoxification) and O-acetylation (usually bioactivation) of a wide range of species-specific substrates including hydrazines, aromatic amine drugs and aromatic amine carcinogens (Probable) (PubMed:9168895). Transfers an acetyl group from acetyl-coenzyme A to arylamine and N-hydroxyarylamine acceptor substrates (Probable) (PubMed:9168895). Can also transfer an N-acetyl group from an N-hydroxy acetylamine to either N-hydroxyarylamine or arylamine in the absence of acetyl-coenzyme A (PubMed:9168895). Therefore, activates N-hydroxyarylamines to unstable acetoxy intermediates which decompose to electrophiles, bind to DNA, and lead to mutagenesis and carcinogenesis (PubMed:9168895). Plays a significant role in the bioactivation and detoxification of many drugs and carcinogens (Probable) (PubMed:9168895). {ECO:0000269|PubMed:9168895, ECO:0000305|PubMed:1968463, ECO:0000305|PubMed:2340091}.
uniprot
proteins
mass_dalton
33899
uniprot
proteins
mutagenesis
MUTAGEN 64; /note="R->A,M,Q,K: Reduced enzymatic activity."; /evidence="ECO:0000269|PubMed:9173883
uniprot
proteins
protein_family
Arylamine N-acetyltransferase family
uniprot
proteins
pubmed
10862520
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16416399
uniprot
proteins
pubmed
1676262
uniprot
proteins
pubmed
17656365
uniprot
proteins
pubmed
1968463
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
2340091
uniprot
proteins
pubmed
7585580
uniprot
proteins
pubmed
8442668
uniprot
proteins
pubmed
9168895
uniprot
proteins
pubmed
9173883
uniprot
proteins
pubmed
9511182
uniprot
proteins
pubmed
9511183
uniprot
proteins
pubmed
9682272
uniprot
proteins
sequence_length
290
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P50294}.
uniprot
proteins