SEC11A
entrez
23478
canonical
uniprot
P67812
canonical
ensembl
ENSG00000140612
resolver
ensp
ENSP00000268220
resolver
ensp
ENSP00000413121
resolver
ensp
ENSP00000452684
resolver
ensp
ENSP00000452697
resolver
ensp
ENSP00000452932
resolver
ensp
ENSP00000453930
resolver
enst
ENST00000559729
resolver
genesymbol
SEC11A
resolver
genesymbol_syn
SEC11L1
resolver
genesymbol_syn
SPC18
resolver
genesymbol_syn
SPCS4A
resolver
hgnc
HGNC:17718
resolver
uniprot
B2RAD7
resolver
uniprot
B4DUL4
resolver
uniprot
H0YK72
resolver
uniprot
H0YK83
resolver
uniprot
H0YKT4
resolver
uniprot
O75957
resolver
uniprot
P21378
resolver
uniprot
Q53FQ8
resolver
uniprot_entry
H0YKT4_HUMAN
resolver
uniprot_entry
SC11A_HUMAN
resolver
uniprot_sec
B2RAD7
resolver
uniprot_sec
B4DUL4
resolver
uniprot_sec
H0YK72
resolver
uniprot_sec
H0YK83
resolver
uniprot_sec
O75957
resolver
uniprot_sec
P21378
resolver
uniprot_sec
Q53FQ8
resolver
amino_acid_sequence
MLSLDFLDDVRRMNKRQLYYQVLNFGMIVSSALMIWKGLMVITGSESPIVVVLSGSMEPAFHRGDLLFLTNRVEDPIRVGEIVVFRIEGREIPIVHRVLKIHEKQNGHIKFLTKGDNNAVDDRGLYKQGQHWLEKKDVVGRARGFVPYIGIVTILMNDYPKFKYAVLFLLGLFVLVHRE
uniprot
proteins
ec_number
3.4.21.89
uniprot
proteins
function
FUNCTION: Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (PubMed:34388369). {ECO:0000269|PubMed:34388369}.
uniprot
proteins
mass_dalton
20625
uniprot
proteins
mutagenesis
MUTAGEN 56; /note="S->A: Loss of catalytic activity."; /evidence="ECO:0000269|PubMed:34388369"; MUTAGEN 97; /note="R->D: Slight reduction in catalytic activity; when associated with R-116."; /evidence="ECO:0000269|PubMed:34388369"; MUTAGEN 116; /note="D->N: Moderate reduction in catalytic activity. Reduces protein stability."; /evidence="ECO:0000269|PubMed:34388369"; MUTAGEN 116; /note="D->R: Slight reduction in catalytic activity; when associated with D-97."; /evidence="ECO:0000269|PubMed:34388369"; MUTAGEN 121; /note="D->N: No effect on catalytic activity or protein stability."; /evidence="ECO:0000269|PubMed:34388369"; MUTAGEN 122; /note="D->N: Loss of catalytic activity. Slight reduction in protein stability."; /evidence="ECO:0000269|PubMed:34388369
uniprot
proteins
protein_family
Peptidase S26B family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
34388369
uniprot
proteins
sequence_length
179
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P67811}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P67811}.
uniprot
proteins
transmembrane_region
TRANSMEM 17..36; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins