PRAME
entrez
23532
canonical
uniprot
P78395
canonical
ensembl
ENSG00000185686
resolver
ensembl
ENSG00000275013
resolver
ensp
ENSP00000381726
resolver
ensp
ENSP00000381728
resolver
ensp
ENSP00000384343
resolver
ensp
ENSP00000385198
resolver
ensp
ENSP00000445097
resolver
ensp
ENSP00000445675
resolver
ensp
ENSP00000484066
resolver
ensp
ENSP00000486330
resolver
ensp
ENSP00000486485
resolver
enst
ENST00000398741
resolver
enst
ENST00000398743
resolver
enst
ENST00000402697
resolver
enst
ENST00000405655
resolver
enst
ENST00000539862
resolver
enst
ENST00000543184
resolver
enst
ENST00000617728
resolver
enst
ENST00000626503
resolver
enst
ENST00000628830
resolver
genesymbol
PRAME
resolver
genesymbol_syn
MAPE
resolver
genesymbol_syn
OIP4
resolver
hgnc
HGNC:9336
resolver
uniprot
B2R6Y7
resolver
uniprot
B7Z7K8
resolver
uniprot
B7Z986
resolver
uniprot
B7ZAT0
resolver
uniprot
O43481
resolver
uniprot
Q8IXN8
resolver
uniprot_entry
B7Z7K8_HUMAN
resolver
uniprot_entry
B7Z986_HUMAN
resolver
uniprot_entry
B7ZAT0_HUMAN
resolver
uniprot_entry
PRAME_HUMAN
resolver
uniprot_sec
B2R6Y7
resolver
uniprot_sec
O43481
resolver
uniprot_sec
Q8IXN8
resolver
amino_acid_sequence
MERRRLWGSIQSRYISMSVWTSPRRLVELAGQSLLKDEALAIAALELLPRELFPPLFMAAFDGRHSQTLKAMVQAWPFTCLPLGVLMKGQHLHLETFKAVLDGLDVLLAQEVRPRRWKLQVLDLRKNSHQDFWTVWSGNRASLYSFPEPEAAQPMTKKRKVDGLSTEAEQPFIPVEVLVDLFLKEGACDELFSYLIEKVKRKKNVLRLCCKKLKIFAMPMQDIKMILKMVQLDSIEDLEVTCTWKLPTLAKFSPYLGQMINLRRLLLSHIHASSYISPEKEEQYIAQFTSQFLSLQCLQALYVDSLFFLRGRLDQLLRHVMNPLETLSITNCRLSEGDVMHLSQSPSVSQLSVLSLSGVMLTDVSPEPLQALLERASATLQDLVFDECGITDDQLLALLPSLSHCSQLTTLSFYGNSISISALQSLLQHLIGLSNLTHVLYPVPLESYEDIHGTLHLERLAYLHARLRELLCELGRPSMVWLSANPCPHCGDRTFYDPEPILCPCFMPN
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex, which mediates ubiquitination of target proteins, leading to their degradation (PubMed:21822215, PubMed:26138980). The CRL2(PRAME) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding (PubMed:26138980). In the nucleus, the CRL2(PRAME) complex is recruited to epigenetically and transcriptionally active promoter regions bound by nuclear transcription factor Y (NFY) and probably plays a role in chromstin regulation (PubMed:21822215). Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG: prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis (PubMed:16179254). {ECO:0000269|PubMed:16179254, ECO:0000269|PubMed:21822215, ECO:0000269|PubMed:26138980}.
uniprot
proteins
mass_dalton
57890
uniprot
proteins
mutagenesis
MUTAGEN 26..30; /note="LVELA->PVELF: Impaired formation of the CRL2(PRAME) complex."; /evidence="ECO:0000269|PubMed:21822215"; MUTAGEN 48..49; /note="LP->AA: Impaired formation of the CRL2(PRAME) complex."; /evidence="ECO:0000269|PubMed:21822215"; MUTAGEN 470..471; /note="LL->VV: Loss of interaction with RARA and defective in repressing RARA signaling."; /evidence="ECO:0000269|PubMed:16179254
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:21822215, ECO:0000269|PubMed:26138980}.
uniprot
proteins
protein_family
PRAME family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16179254
uniprot
proteins
pubmed
16620968
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21822215
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23460923
uniprot
proteins
pubmed
26138980
uniprot
proteins
pubmed
9047241
uniprot
proteins
pubmed
9466265
uniprot
proteins
sequence_length
509
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21822215, ECO:0000269|PubMed:23460923, ECO:0000305|PubMed:16620968}. Chromosome {ECO:0000269|PubMed:21822215}. Cytoplasm {ECO:0000269|PubMed:23460923}. Golgi apparatus {ECO:0000269|PubMed:23460923}. Cell membrane {ECO:0000269|PubMed:16620968}. Note=Associates with chromatin; specifically enriched at transcriptionally active promoters that are also bound by nuclear transcription factor Y (composed of NFYA, NFYB and NFYC) and at enhancers (PubMed:21822215). Recruited to the Golgi apparatus in response to interferon gamma (IFNG) treatment (PubMed:23460923). {ECO:0000269|PubMed:21822215, ECO:0000269|PubMed:23460923}.
uniprot
proteins