TOMM20
entrez
9804
canonical
uniprot
Q15388
canonical
ensembl
ENSG00000173726
resolver
ensp
ENSP00000355566
resolver
enst
ENST00000366607
resolver
genesymbol
TOMM20
resolver
genesymbol_syn
KIAA0016
resolver
hgnc
HGNC:20947
resolver
uniprot
A8K195
resolver
uniprot
Q498B3
resolver
uniprot
Q6IBT4
resolver
uniprot_entry
TOM20_HUMAN
resolver
uniprot_sec
A8K195
resolver
uniprot_sec
Q498B3
resolver
uniprot_sec
Q6IBT4
resolver
amino_acid_sequence
MVGRNSAIAAGVCGALFIGYCIYFDRKRRSDPNFKNRLRERRKKQKLAKERAGLSKLPDLKDAEAVQKFFLEEIQLGEELLAQGEYEKGVDHLTNAIAVCGQPQQLLQVLQQTLPPPVFQMLLTKLPTISQRIVSAQSLAEDDVE
uniprot
proteins
function
FUNCTION: Central receptor component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (PubMed:40080546). Together with TOMM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (PubMed:18331822). The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (PubMed:40080546). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases (By similarity). {ECO:0000250|UniProtKB:Q62760, ECO:0000269|PubMed:18331822, ECO:0000269|PubMed:40080546}.
uniprot
proteins
mass_dalton
16298
uniprot
proteins
mutagenesis
MUTAGEN 56; /note="K->R: Defects in mitophagy; when associated with R-61 and R-68."; /evidence="ECO:0000269|PubMed:24896179"; MUTAGEN 61; /note="K->R: Defects in mitophagy; when associated with R-56 and R-68."; /evidence="ECO:0000269|PubMed:24896179"; MUTAGEN 68; /note="K->R: Defects in mitophagy; when associated with R-56 and R-61."; /evidence="ECO:0000269|PubMed:24896179
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. {ECO:0000269|PubMed:24896179, ECO:0000269|PubMed:25621951}.
uniprot
proteins
protein_family
Tom20 family
uniprot
proteins
pubmed
10548729
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18331822
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20231292
uniprot
proteins
pubmed
20628368
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24896179
uniprot
proteins
pubmed
25621951
uniprot
proteins
pubmed
25764979
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
25997101
uniprot
proteins
pubmed
31644573
uniprot
proteins
pubmed
38416681
uniprot
proteins
pubmed
38848361
uniprot
proteins
pubmed
40080546
uniprot
proteins
pubmed
7498524
uniprot
proteins
pubmed
7584026
uniprot
proteins
pubmed
7589431
uniprot
proteins
sequence_length
145
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:20628368, ECO:0000269|PubMed:25764979, ECO:0000269|PubMed:25997101, ECO:0000269|PubMed:31644573}; Single-pass membrane protein {ECO:0000269|PubMed:40080546}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..24; /note="Helical"; /evidence="ECO:0000269|PubMed:40080546, ECO:0007744|PDB:9EIH, ECO:0007744|PDB:9EII, ECO:0007744|PDB:9EIJ
uniprot
proteins