PTPRC
entrez
5788
canonical
uniprot
P08575
canonical
ensembl
ENSG00000081237
resolver
ensembl
ENSG00000262418
resolver
ensp
ENSP00000306782
resolver
ensp
ENSP00000405494
resolver
ensp
ENSP00000411355
resolver
ensp
ENSP00000458322
resolver
ensp
ENSP00000461074
resolver
ensp
ENSP00000513363
resolver
ensp
ENSP00000640682
resolver
ensp
ENSP00000640684
resolver
enst
ENST00000413409
resolver
enst
ENST00000573477
resolver
enst
ENST00000573679
resolver
genesymbol
PTPRC
resolver
genesymbol_syn
CD45
resolver
hgnc
HGNC:9666
resolver
uniprot
A0A0A0MT22
resolver
uniprot
A8K7W6
resolver
uniprot
M9MML4
resolver
uniprot
Q16614
resolver
uniprot
Q9H0Y6
resolver
uniprot
X6R433
resolver
uniprot_entry
M9MML4_HUMAN
resolver
uniprot_entry
PTPRC_HUMAN
resolver
uniprot_sec
A0A0A0MT22
resolver
uniprot_sec
A8K7W6
resolver
uniprot_sec
Q16614
resolver
uniprot_sec
Q9H0Y6
resolver
uniprot_sec
X6R433
resolver
amino_acid_sequence
MTMYLWLKLLAFGFAFLDTEVFVTGQSPTPSPTGLTTAKMPSVPLSSDPLPTHTTAFSPASTFERENDFSETTTSLSPDNTSTQVSPDSLDNASAFNTTGVSSVQTPHLPTHADSQTPSAGTDTQTFSGSAANAKLNPTPGSNAISDVPGERSTASTFPTDPVSPLTTTLSLAHHSSAALPARTSNTTITANTSDAYLNASETTTLSPSGSAVISTTTIATTPSKPTCDEKYANITVDYLYNKETKLFTAKLNVNENVECGNNTCTNNEVHNLTECKNASVSISHNSCTAPDKTLILDVPPGVEKFQLHDCTQVEKADTTICLKWKNIETFTCDTQNITYRFQCGNMIFDNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNPPQRSFHNFTLCYIKETEKDCLNLDKNLIKYDLQNLKPYTKYVLSLHAYIIAKVQRNGSAAMCHFTTKSAPPSQVWNMTVSMTSDNSMHVKCRPPRDRNGPHERYHLEVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFKAYFHNGDYPGEPFILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERDDEKQLMNVEPIHADILLETYKRKIADEGRLFLAEFQSIPRVFSKFPIKEARKPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWRMIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKKEKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTYIGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQVEAQYILIHQALVEYNQFGETEVNLSELHPYLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENKSKNRNSNVIPYDYNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASFIMSYWKPEVMIAAQGPLKETIGDFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKDTDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGNKHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKARPGMVSTFEQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTSGTEGPEHSVNGPASPALNQGS
uniprot
proteins
disease_involvement
DISEASE: Multiple sclerosis (MS) [MIM:126200]: A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheath, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. {ECO:0000269|PubMed:11101853}. Note=Disease susceptibility may be associated with variants affecting the gene represented in this entry.; DISEASE: Immunodeficiency 105, severe combined (IMD105) [MIM:619924]: An autosomal recessive disorder characterized by recurrent infections in early infancy, decreased or absent numbers of non-functional T cells, normal or increased levels of B cells, hypogammaglobulinemia, and normal or low NK cells. Clinical manifestations may include pneumonia, dermatitis, and lymphadenopathy. {ECO:0000269|PubMed:10700239, ECO:0000269|PubMed:11145714, ECO:0000269|PubMed:22689986}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor (PubMed:35767951). Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). Interacts with CLEC10A at antigen presenting cell-T cell contact; CLEC10A on immature dendritic cells recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and modulates T cell activation threshold to limit autoreactivity. {ECO:0000250, ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:16998493, ECO:0000269|PubMed:2845400, ECO:0000269|PubMed:35767951}.; FUNCTION: (Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation. {ECO:0000269|PubMed:22174689}.
uniprot
proteins
mass_dalton
147486
uniprot
proteins
mutagenesis
MUTAGEN 853; /note="C->S: Loss of activity. Abolishes interaction with SKAP1."; /evidence="ECO:0000269|PubMed:11909961
uniprot
proteins
post_translational_modification
PTM: Heavily N- and O-glycosylated. {ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19349973}.
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
protein_family
Receptor class 1/6 subfamily
uniprot
proteins
pubmed
10700239
uniprot
proteins
pubmed
11101853
uniprot
proteins
pubmed
11145714
uniprot
proteins
pubmed
11909961
uniprot
proteins
pubmed
11975983
uniprot
proteins
pubmed
12676959
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15684325
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
1695146
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
16998493
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22174689
uniprot
proteins
pubmed
22689986
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2531281
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
2824653
uniprot
proteins
pubmed
2845400
uniprot
proteins
pubmed
2956090
uniprot
proteins
pubmed
2971730
uniprot
proteins
pubmed
35767951
uniprot
proteins
sequence_length
1306
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12676959, ECO:0000269|PubMed:22174689}; Single-pass type I membrane protein {ECO:0000255}. Membrane raft {ECO:0000269|PubMed:12676959}. Synapse {ECO:0000269|PubMed:35767951}. Note=Colocalized with DPP4 in membrane rafts. {ECO:0000269|PubMed:12676959}.
uniprot
proteins
transmembrane_region
TRANSMEM 578..598; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins