EMSY
entrez
56946
canonical
uniprot
Q7Z589
canonical
ensembl
ENSG00000158636
resolver
ensp
ENSP00000334130
resolver
ensp
ENSP00000432010
resolver
ensp
ENSP00000433634
resolver
ensp
ENSP00000436968
resolver
ensp
ENSP00000511840
resolver
ensp
ENSP00000554955
resolver
ensp
ENSP00000554956
resolver
ensp
ENSP00000554957
resolver
ensp
ENSP00000554959
resolver
ensp
ENSP00000554961
resolver
ensp
ENSP00000554964
resolver
ensp
ENSP00000554965
resolver
ensp
ENSP00000554966
resolver
ensp
ENSP00000554968
resolver
ensp
ENSP00000554970
resolver
ensp
ENSP00000554971
resolver
ensp
ENSP00000554973
resolver
ensp
ENSP00000586823
resolver
genesymbol
EMSY
resolver
genesymbol_syn
C11orf30
resolver
hgnc
HGNC:18071
resolver
uniprot
B7ZKT8
resolver
uniprot
B7ZKU0
resolver
uniprot
B7ZKU2
resolver
uniprot
Q17RM7
resolver
uniprot
Q4G109
resolver
uniprot
Q8NBU6
resolver
uniprot
Q8TE50
resolver
uniprot
Q9H8I9
resolver
uniprot
Q9NRH0
resolver
uniprot_entry
EMSY_HUMAN
resolver
uniprot_sec
B7ZKT8
resolver
uniprot_sec
B7ZKU0
resolver
uniprot_sec
B7ZKU2
resolver
uniprot_sec
Q17RM7
resolver
uniprot_sec
Q4G109
resolver
uniprot_sec
Q8NBU6
resolver
uniprot_sec
Q8TE50
resolver
uniprot_sec
Q9H8I9
resolver
uniprot_sec
Q9NRH0
resolver
amino_acid_sequence
MPVVWPTLLDLSRDECKRILRKLELEAYAGVISALRAQGDLTKEKKDLLGELSKVLSISTERHRAEVRRAVNDERLTTIAHNMSGPNSSSEWSIEGRRLVPLMPRLVPQTAFTVTANAVANAAIQHNASLPVPAETGSKEVVCYSYTSTTSTPTSTPVPSGSIATVKSPRPASPASNVVVLPSGSTVYVKSVSCSDEDEKPRKRRRTNSSSSSPVVLKEVPKAVVPVSKTITVPVSGSPKMSNIMQSIANSLPPHMSPVKITFTKPSTQTTNTTTQKVIIVTTSPSSTFVPNILSKSHNYAAVTKLVPTSVIASTTQKPPVVITASQSSLVSNSSSGSSSSTPSPIPNTVAVTAVVSSTPSVVMSTVAQGVSTSAIKMASTRLPSPKSLVSAPTQILAQFPKQHQQSPKQQLYQVQQQTQQQVAQPSPVSHQQQPQQSPLPPGIKPTIQIKQESGVKIITQQVQPSKILPKPVTATLPTSSNSPIMVVSSNGAIMTTKLVTTPTGTQATYTRPTVSPSIGRMAATPGAATYVKTTSGSIITVVPKSLATLGGKIISSNIVSGTTTKITTIPMTSKPNVIVVQKTTGKGTTIQGLPGKNVVTTLLNAGGEKTIQTVPTGAKPAILTATRPITKMIVTQPKGIGSTVQPAAKIIPTKIVYGQQGKTQVLIKPKPVTFQATVVSEQTRQLVTETLQQASRVAEAGNSSIQEGKEEPQNYTDSSSSSTESSQSSQDSQPVVHVIASRRQDWSEHEIAMETSPTIIYQDVSSESQSATSTIKALLELQQTTVKEKLESKPRQPTIDLSQMAVPIQMTQEKRHSPESPSIAVVESELVAEYITTERTDEGTEVAFPLLVSHRSQPQQPSQPQRTLLQHVAQSQTATQTSVVVKSIPASSPGAITHIMQQALSSHTAFTKHSEELGTEEGEVEEMDTLDPQTGLFYRSALTQSQSAKQQKLSQPPLEQTQLQVKTLQCFQTKQKQTIHLQADQLQHKLPQMPQLSIRHQKLTPLQQEQAQPKPDVQHTQHPMVAKDRQLPTLMAQPPQTVVQVLAVKTTQQLPKLQQAPNQPKIYVQPQTPQSQMSLPASSEKQTASQVEQPIITQGSSVTKITFEGRQPPTVTKITGGSSVPKLTSPVTSISPIQASEKTAVSDILKMSLMEAQIDTNVEHMIVDPPKKALATSMLTGEAGSLPSTHMVVAGMANSTPQQQKCRESCSSPSTVGSSLTTRKIDPPAVPATGQFMRIQNVGQKKAEESPAEIIIQAIPQYAIPCHSSSNVVVEPSGLLELNNFTSQQLDDEETAMEQDIDSSTEDGTEPSPSQSSAERS
uniprot
proteins
function
FUNCTION: Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (PubMed:14651845). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (PubMed:14651845). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (PubMed:19131338). {ECO:0000269|PubMed:14651845, ECO:0000269|PubMed:19131338}.
uniprot
proteins
mass_dalton
141468
uniprot
proteins
mutagenesis
MUTAGEN 100..102; /note="VPL->APA: Abolishes interaction with CBX1."; /evidence="ECO:0000269|PubMed:14651845"; MUTAGEN 106; /note="L->A: Abolishes interaction with ZMYND11."; /evidence="ECO:0000269|PubMed:14651845
uniprot
proteins
post_translational_modification
PTM: O-glycosylated during cytokinesis at sites identical or close to phosphorylation sites, this interferes with the phosphorylation status. {ECO:0000269|PubMed:20068230}.
uniprot
proteins
pubmed
14651845
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15947784
uniprot
proteins
pubmed
15978617
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16615912
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19131338
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068230
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
1322
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14651845}. Note=Localizes to DNA damage markers in irradiated cells, suggesting that it participates in DNA repair process.
uniprot
proteins