Spef2
entrez
64555
canonical
uniprot
Q9R095
canonical
ensembl
ENSRNOG00000058275
resolver
ensp
ENSRNOP00000070321
resolver
enst
ENSRNOT00000086323
resolver
genesymbol
Spef2
resolver
genesymbol_syn
Kpl2
resolver
uniprot
A0A0G2JXL6
resolver
uniprot
Q4V8M1
resolver
uniprot_entry
A0A0G2JXL6_RAT
resolver
uniprot_entry
SPEF2_RAT
resolver
uniprot_sec
Q4V8M1
resolver
amino_acid_sequence
MSEILCQWLNQELKVSRTVSPKSFAKTFSNGYLIGEVLFKFELQSDFSEFSESRVSTAKLNNFSRLQPTLHLLGVQFDQNVAQSIITEKPGAATKLLYQLYIALQKKKKTGLTGLEIQTMQPQTNQRLQALKSEAFRERLKNLIPRQTDFNLMRVTCRFQEKCKQMKEDLARMHFEKFEKIQKLEEEQRHFNIEKQRLNRRRQNEIMAKIQAAIIQIPKPEPNRTLKAIEAQKLMKKKKEAEDVANEIKKFEALIKKDLQTRESISKTSLDTIDQTAAELLNTYSDDDYIKKIQKRLEEDAFAREQREKRRRRLLMDQLIAHEAQEEAYREEQLIHRLMRQSQQERRIAVQLMHVRHEKEVLWQNRIFREKQFEERRLKDFQDALDREAALTKQAKIDFAEQTLRAKEIHEKIAMERAQQRYEKHYGICAEILDQILDLCTKVADYRLLTNNLIPHKMMRDWKELFFSGNPIYEQTSHTHGQTESTEDHHVELNKRNLLDSKDYEDYKNMTGEWALPEDMANSSPPSNNNILGHVLLRLIENSYPSEKEVADTELPSFAVKGCLLGKTLSGKTTILKALQNDIPIQVLSIDTLVQEAIQAFNDGEKSSKAPSMHEDVKGDPEVDQKEMIIPQDKNELTDTQVPGEAAPQKEGTKSSDFEQFRPSNSFLSLSMRAQLGAKSELMLRRGKSVPDVLLVNILVNAIKKIPVNQSWVLDGFPMTVNQAKLLEEALTGYKRKSLQLKKKKAQMPTLALSPTTSKEVPFLPSAFDFAILLDISDNSSLARINDIIAKEISHEISHENVSGPTITSSEEKSEDRNLRDHIQHRIVGFLDNWPLLEEWFTEPRNILKKVNAEIDEAFLCQKIKEIFATEVSNKKIKVEKKLEEKETEKKSAVSPTEPPTPTPPLASEAEKEKEVHQAKPSGKGKTQSVSPKGKAQGGKISVKKSPIDSTEVSPTLIAMPTTKPGSEEWVYVTEPIPEELPSFLVPYWELIEKTYISHIKTVLRQLRESQHTVLSYLYETRTSFQEFLRRPDHKQDFVSQWQADFNSVPEDLWEDEETKAELHQRVNDLRDRLWDICEARKEEAEQERLDIINESWLQDYIGITMNHFFSLMQAEVNRFQDTKRLLQDYYRAMESRIPLEDNKKFTRIPLVQLDGKEISEHQLRIPLVPRISSSPENVSMRPKVKALLKGRFDPPLESLEANFEGDEKIVLDTWQQASLAISQMVAAEVHQRLAEEEKEQPQLDPKEKSPQSGTNKKAKKEKEQAKKEKEQAKKEKEQAKKEKEPPKKKMAEKKGKGKSSPVVEVSPVTITPEEMAEMERKNELKLKIKEEHLAALQTEEQATQFRLELIKSKALSILEDLVTKVIEVYRFMEKWLGKRYLNEMASIQKLTEVARYHIETATKIQNEIYLSQEDFYINGDIKVFPDPPPPTRPPPVEKEENGTLTIEQLDNLRDQFLDMAPKGIIGNKAFTDILLDLVTLNLGTNNLSSSWMHLTQLDLQEITSLLTVNTEFVDWRKFLMVAAMPWPIPLEEELLETLQRFKATDEAQTGTITFEQYKQAGLWFSGDEDIKIPENPLEPLPFNRQEHLIEFFFRLFADSEKDPPQLDYTQMLLYFACHPDTLEGVYRALSVAVGTHIFRQVETPMLTAEKTSISSVSPNEEFPEAEENSTREELKEEKDERDQKEEEIPENANTEKISMETLLKVFGGGNEVLDANRFASYLKTENIYSENLIKTFQDLGAKNLEPIEVNILLKHPYIQDLITNYVDYKIPDIKMILQRSEHAQGSDGERSPSRLTDEKK
uniprot
proteins
function
FUNCTION: Required for correct axoneme development in spermatozoa. Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis. Plays a role in bone growth where it seems to be required for normal osteoblast differentiation. Required for normal beat frequency of tracheal epithelial cilia and oviduct cilia. {ECO:0000250|UniProtKB:Q8C9J3, ECO:0000250|UniProtKB:Q9C093}.
uniprot
proteins
mass_dalton
208159
uniprot
proteins
pubmed
10100999
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
1801
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9C093}. Cytoplasm, cytoskeleton, flagellum basal body {ECO:0000250|UniProtKB:Q8C9J3}. Cytoplasm {ECO:0000250|UniProtKB:Q8C9J3}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8C9J3}. Golgi apparatus {ECO:0000250|UniProtKB:Q8C9J3}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q9C093}. Note=Shows dynamic localization in developing spermatozoa. Localizes to the manchette in step 10-12 elongating spermatids. Detected in the basal body and neck area of step 13-14 spermatids. Localizes to the midpiece of the sperm tail in step 15-16 spermatids. During the epididymal transport of spermatozoa, expression in the sperm tail reduces and becomes concentrated at the distal part of the midpiece. Detected in the Golgi apparatus of late spermatocytes and round spermatids. Detected in the cytoplasm of Sertoli cells. Detected in the axoneme of ciliated respiratory epithelial cells. {ECO:0000250|UniProtKB:Q8C9J3, ECO:0000250|UniProtKB:Q9C093}.
uniprot
proteins