Rnf41
entrez
67588
canonical
uniprot
Q8BH75
canonical
ensembl
ENSMUSG00000025373
resolver
ensp
ENSMUSP00000100869
resolver
ensp
ENSMUSP00000132751
resolver
genesymbol
Rnf41
resolver
genesymbol_syn
Flrf
resolver
genesymbol_syn
Nrdp1
resolver
uniprot
Q8BGJ2
resolver
uniprot
Q8BMC9
resolver
uniprot
Q8VEA2
resolver
uniprot
Q9CRK6
resolver
uniprot
Q9D568
resolver
uniprot_entry
RNF41_MOUSE
resolver
uniprot_sec
Q8BGJ2
resolver
uniprot_sec
Q8BMC9
resolver
uniprot_sec
Q8VEA2
resolver
uniprot_sec
Q9CRK6
resolver
uniprot_sec
Q9D568
resolver
amino_acid_sequence
MGYDVTRFQGDVDEDLICPICSGVLEEPVQAPHCEHAFCNACITQWFSQQQTCPVDRSVVTVAHLRPVPRIMRNMLSKLQIACDNAVFGCSAVVRLDNLMSHLSDCEHNPKRPVTCEQGCGLEMPKDELPNHNCIKHLRSVVQQQQSRIAELEKTSAEHKHQLAEQKRDIQLLKAYMRAIRSVNPNLQNLEETIEYNEILEWVNSLQPARVTRWGGMISTPDAVLQAVIKRSLVESGCPASIVNELIENAHERSWPQGLATLETRQMNRRYYENYVAKRIPGKQAVVVMACENQHMGDDMVQEPGLVMIFAHGVEEI
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88 (By similarity). Negatively regulates MYD88-dependent production of pro-inflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus. Also promotes activation of TBK1 and IRF3 (PubMed:19483718). Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (PubMed:18495327). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Also acts as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970). {ECO:0000250, ECO:0000269|PubMed:18495327, ECO:0000269|PubMed:19483718, ECO:0000269|PubMed:24949970}.
uniprot
proteins
mass_dalton
35891
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. Autoubiquitination leads to proteasomal degradation. Deubiquitinated by USP8 to get stabilized which induces apoptosis. {ECO:0000250}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17384230
uniprot
proteins
pubmed
18495327
uniprot
proteins
pubmed
19483718
uniprot
proteins
pubmed
24949970
uniprot
proteins
sequence_length
317
uniprot
proteins