Cmpk2
entrez
22169
canonical
uniprot
Q3U5Q7
canonical
ensembl
ENSMUSG00000020638
resolver
ensp
ENSMUSP00000020969
resolver
enst
ENSMUST00000020969
resolver
genesymbol
Cmpk2
resolver
genesymbol_syn
Tyki
resolver
uniprot
Q3UCI7
resolver
uniprot
Q5XKG5
resolver
uniprot
Q62316
resolver
uniprot
Q6PFG7
resolver
uniprot
Q9DC34
resolver
uniprot_entry
CMPK2_MOUSE
resolver
uniprot_sec
Q3UCI7
resolver
uniprot_sec
Q5XKG5
resolver
uniprot_sec
Q62316
resolver
uniprot_sec
Q6PFG7
resolver
uniprot_sec
Q9DC34
resolver
amino_acid_sequence
MALISRPRAPLWLGRLSRRLCGRHQACMGTMARPRRFTVELPDCSLTHFVLGDATDHRDARLAELLGPPGRSYALCVPLAPGEGCGPRVQAARVHHRLLQQLRRGPLQRCQLSKLLGYGPGDQAGEAQHGFLLRDPCDHPDTRRDLLQLLGSCQEAARPQLAEFQADSQGLLWQRLWELQGDRQVQVDCACVLPAQEPHLHPLLPDLLNSAVFQDRDAARAVLEECTSFIPEARAVLDLVDQCPKEVQKGKFQVIAIEGLDATGKTTLTQSVSESLKAVLLQSPPPCISQWRKIFDDEPTIIRRAFYSLGNYLVASEIAKESTNFPVIVDRYWHSTATYAIATEVSGGLQYLPPAHHPVYQWPGDLLKPDLVLLLTVNSEERVRRLQGRGQEKTKEEAELEANNVFRQKVEMTYQRMENPSCHLVDASPSRETVLQKVLELIQSSGR
uniprot
proteins
ec_number
2.7.4.14
uniprot
proteins
ec_number
2.7.4.6
uniprot
proteins
function
FUNCTION: Mitochondrial nucleotide monophosphate kinase needed for salvage dNTP synthesis that mediates immunomodulatory and antiviral activities through IFN-dependent and IFN-independent pathways. Restricts the replication of multiple viruses including flaviviruses or coronaviruses. Together with viperin/RSAD2 and ddhCTP, suppresses the replication of several coronaviruses through inhibition of the viral RNA-dependent RNA polymerase activities (By similarity). Concerning flaviviruses, restricts RNA translation when localized to the mitochondria independently of its kinase activity (By similarity). Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP while CMP and UMP are poor substrates. Controls therefore mitochondrial DNA synthesis by supplying required deoxyribonucleotides (PubMed:36443312). CMPK2-dependent mitochondrial DNA synthesis is necessary for the production of oxidized mitochondrial DNA fragments after exposure to NLRP3 activators (PubMed:30046112). In turn, cytosolic oxidized mtDNA associates with the NLRP3 inflammasome complex and is required for its activation (PubMed:30046112). {ECO:0000250|UniProtKB:Q5EBM0, ECO:0000269|PubMed:30046112, ECO:0000269|PubMed:36443312}.
uniprot
proteins
mass_dalton
50036
uniprot
proteins
mutagenesis
MUTAGEN 330; /note="D->E: Catalytically inactive with subsequent loss of NLRP3 inflammasome activation."; /evidence="ECO:0000269|PubMed:30046112
uniprot
proteins
protein_family
Thymidylate kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16996144
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30046112
uniprot
proteins
pubmed
36443312
uniprot
proteins
pubmed
7751651
uniprot
proteins
sequence_length
447
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:36443312}.
uniprot
proteins