Anapc11
entrez
66156
canonical
uniprot
Q9CPX9
canonical
ensembl
ENSMUSG00000025135
resolver
ensp
ENSMUSP00000026128
resolver
ensp
ENSMUSP00000097714
resolver
enst
ENSMUST00000026128
resolver
enst
ENSMUST00000093140
resolver
genesymbol
Anapc11
resolver
uniprot
Q3UWH1
resolver
uniprot
Q9CTG0
resolver
uniprot_entry
APC11_MOUSE
resolver
uniprot_sec
Q3UWH1
resolver
uniprot_sec
Q9CTG0
resolver
amino_acid_sequence
MKVKIKCWNGVATWLWVANDENCGICRMAFNGCCPDCKVPGDDCPLVWGQCSHCFHMHCILKWLNAQQVQQHCPMCRQEWKFKE
uniprot
proteins
function
FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (By similarity). Together with ANAPC2, forms the catalytic component of the E3 ubiquitin ligase complex (By similarity). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (By similarity). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (By similarity). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (By similarity). {ECO:0000250|UniProtKB:Q9NYG5}.
uniprot
proteins
mass_dalton
9818
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9NYG5}.
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated. {ECO:0000250}.
uniprot
proteins
protein_family
RING-box family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
84
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
uniprot
proteins