Tp53inp1
entrez
297822
canonical
uniprot
Q80YE2
canonical
ensembl
ENSRNOG00000078269
resolver
ensp
ENSRNOP00000105911
resolver
enst
ENSRNOT00000172896
resolver
genesymbol
Tp53inp1
resolver
genesymbol
Trp53inp1
resolver
genesymbol_syn
Sip
resolver
uniprot
A0ABK0LVL3
resolver
uniprot_entry
A0ABK0LVL3_RAT
resolver
uniprot_entry
T53I1_RAT
resolver
amino_acid_sequence
MFQRLNKMFVGEVTTSSSHEPEFSEKEDDEWILVDFIDTCTGFSAEEEEEDEDIGEESSAEHTSVFSCLPTSLECLADTSDSCFLQFESCPMEESWFITPPPCFTAGGLTTIKVETSPMENLLIEHPSMSVYAVHNSCPGLSEASCGNDDYNSSGPRMEAQSELGTHIHCCVAALAAQATFLEQPKSFRPSQWIKGHSERQSLNRNGLRRQNLTRDCHTRQMKHRCWAVHQPCPRQYNY
uniprot
proteins
function
FUNCTION: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
26976
uniprot
proteins
pubmed
15254349
uniprot
proteins
sequence_length
239
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Cytoplasmic vesicle, autophagosome {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation. {ECO:0000250}.
uniprot
proteins