NOCT
entrez
25819
canonical
uniprot
Q9UK39
canonical
ensembl
ENSG00000151014
resolver
ensp
ENSP00000280614
resolver
enst
ENST00000280614
resolver
genesymbol
NOCT
resolver
genesymbol_syn
CCR4
resolver
genesymbol_syn
CCRN4L
resolver
genesymbol_syn
NOC
resolver
hgnc
HGNC:14254
resolver
uniprot
D3DNY5
resolver
uniprot
Q14D51
resolver
uniprot
Q9HD93
resolver
uniprot
Q9HD94
resolver
uniprot
Q9HD95
resolver
uniprot_entry
NOCT_HUMAN
resolver
uniprot_sec
D3DNY5
resolver
uniprot_sec
Q14D51
resolver
uniprot_sec
Q9HD93
resolver
uniprot_sec
Q9HD94
resolver
uniprot_sec
Q9HD95
resolver
amino_acid_sequence
MFHSPRRLCSALLQRDAPGLRRLPAPGLRRPLSPPAAVPRPASPRLLAAASAASGAARSCSRTVCSMGTGTSRLYSALAKTLNSSAASQHPEYLVSPDPEHLEPIDPKELLEECRAVLHTRPPRFQRDFVDLRTDCPSTHPPIRVMQWNILAQALGEGKDNFVQCPVEALKWEERKCLILEEILAYQPDILCLQEVDHYFDTFQPLLSRLGYQGTFFPKPWSPCLDVEHNNGPDGCALFFLQNRFKLVNSANIRLTAMTLKTNQVAIAQTLECKESGRQFCIAVTHLKARTGWERFRSAQGCDLLQNLQNITQGAKIPLIVCGDFNAEPTEEVYKHFASSSLNLNSAYKLLSADGQSEPPYTTWKIRTSGECRHTLDYIWYSKHALNVRSALDLLTEEQIGPNRLPSFNYPSDHLSLVCDFSFTEESDGLS
uniprot
proteins
ec_number
3.1.3.108
uniprot
proteins
function
FUNCTION: Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH (PubMed:31147539). Shows a small preference for NADPH over NADP(+) (PubMed:31147539). Represses translation and promotes degradation of target mRNA molecules (PubMed:29860338). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (By similarity). Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (By similarity). Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (By similarity). Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (By similarity). Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (By similarity). Critical for proper development of early embryos (By similarity). {ECO:0000250|UniProtKB:O35710, ECO:0000269|PubMed:29860338, ECO:0000269|PubMed:31147539}.
uniprot
proteins
mass_dalton
48196
uniprot
proteins
mutagenesis
MUTAGEN 149; /note="N->A: Slightly decreased activity as transcriptional repressor."; /evidence="ECO:0000269|PubMed:29860338"; MUTAGEN 160; /note="D->A: Lack of catalytic activity."; /evidence="ECO:0000269|PubMed:31147539"; MUTAGEN 195; /note="E->A: Slightly increased activity as transcriptional repressor. Lack of catalytic activity."; /evidence="ECO:0000269|PubMed:29860338, ECO:0000269|PubMed:31147539"; MUTAGEN 219; /note="K->A: Reduced catalytic activity."; /evidence="ECO:0000269|PubMed:31147539"; MUTAGEN 286; /note="H->A: No effect on activity as transcriptional repressor."; /evidence="ECO:0000269|PubMed:29860338"; MUTAGEN 286; /note="H->N: Lack of catalytic activity."; /evidence="ECO:0000269|PubMed:31147539"; MUTAGEN 288; /note="K->A: Reduced catalytic activity."; /evidence="ECO:0000269|PubMed:31147539"; MUTAGEN 290; /note="R->A: Lack of catalytic activity."; /evidence="ECO:0000269|PubMed:31147539"; MUTAGEN 324; /note="D->A: No effect on activity as transcriptional repressor."; /evidence="ECO:0000269|PubMed:29860338"; MUTAGEN 326; /note="N->A: No effect on activity as transcriptional repressor."; /evidence="ECO:0000269|PubMed:29860338"; MUTAGEN 365; /note="K->A: No effect on catalytic activity."; /evidence="ECO:0000269|PubMed:31147539"; MUTAGEN 367; /note="R->A: Reduced catalytic activity."; /evidence="ECO:0000269|PubMed:31147539"; MUTAGEN 377; /note="D->A: Slightly decreased activity as transcriptional repressor."; /evidence="ECO:0000269|PubMed:29860338"; MUTAGEN 414; /note="H->A,N: Decreased activity as transcriptional repressor."; /evidence="ECO:0000269|PubMed:29860338
uniprot
proteins
protein_family
CCR4/nocturin family
uniprot
proteins
pubmed
10521507
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22331129
uniprot
proteins
pubmed
22608110
uniprot
proteins
pubmed
29860338
uniprot
proteins
pubmed
30389976
uniprot
proteins
pubmed
31147539
uniprot
proteins
sequence_length
431
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O35710}. Nucleus {ECO:0000250|UniProtKB:O35710}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O35710}. Mitochondrion {ECO:0000269|PubMed:31147539}.
uniprot
proteins