FAM168A
entrez
23201
canonical
uniprot
Q92567
canonical
ensembl
ENSG00000054965
resolver
ensp
ENSP00000064778
resolver
ensp
ENSP00000348852
resolver
ensp
ENSP00000390501
resolver
ensp
ENSP00000546845
resolver
genesymbol
FAM168A
resolver
genesymbol_syn
KIAA0280
resolver
genesymbol_syn
TCRP1
resolver
hgnc
HGNC:28999
resolver
uniprot
A2ICY2
resolver
uniprot
A2ID81
resolver
uniprot
Q86UG2
resolver
uniprot_entry
F168A_HUMAN
resolver
uniprot_sec
A2ICY2
resolver
uniprot_sec
A2ID81
resolver
uniprot_sec
Q86UG2
resolver
amino_acid_sequence
MNPVYSPVQPGAPYGNPKNMAYTGYPTAYPAAAPAYNPSLYPTNSPSYAPEFQFLHSAYATLLMKQAWPQNSSSCGTEGTFHLPVDTGTENRTYQASSAAFRYTAGTPYKVPPTQSNTAPPPYSPSPNPYQTAMYPIRSAYPQQNLYAQGAYYTQPVYAAQPHVIHHTTVVQPNSIPSAIYPAPVAAPRTNGVAMGMVAGTTMAMSAGTLLTTPQHTAIGAHPVSMPTYRAQGTPAYSYVPPHW
uniprot
proteins
disease_involvement
DISEASE: Note=Associated with cisplatin (DDP)-resistance and radioresistance in the treatment of lung cancer as well as oral squamous cell carcinoma and poor clinical outcome in patients. {ECO:0000269|PubMed:21334329, ECO:0000269|PubMed:23251525, ECO:0000269|PubMed:25260657}.
uniprot
proteins
function
FUNCTION: In cancer context, decreases POLB ubiquitination and stabilizes its protein levels (PubMed:25260657). Acts, at least in part, through PI3K/AKT/NFKB signaling pathway and by preventing POLB degradation (PubMed:23251525, PubMed:25260657). Results in protection of cells from induced-DNA damage and apoptosis (PubMed:21334329, PubMed:23251525, PubMed:25260657). {ECO:0000269|PubMed:21334329, ECO:0000269|PubMed:23251525, ECO:0000269|PubMed:25260657}.
uniprot
proteins
mass_dalton
26184
uniprot
proteins
protein_family
FAM168 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21334329
uniprot
proteins
pubmed
21603883
uniprot
proteins
pubmed
22771904
uniprot
proteins
pubmed
23251525
uniprot
proteins
pubmed
25260657
uniprot
proteins
pubmed
38656596
uniprot
proteins
pubmed
9039502
uniprot
proteins
sequence_length
244
uniprot
proteins