Myt1l
entrez
116668
canonical
uniprot
P70475
canonical
ensembl
ENSRNOG00000004269
resolver
ensembl
ENSRNOG00055005769
resolver
ensembl
ENSRNOG00060009075
resolver
ensembl
ENSRNOG00065010591
resolver
ensp
ENSRNOP00000005905
resolver
ensp
ENSRNOP00000084839
resolver
ensp
ENSRNOP00000109546
resolver
enst
ENSRNOT00000005905
resolver
enst
ENSRNOT00000095119
resolver
enst
ENSRNOT00000148709
resolver
genesymbol
Myt1l
resolver
genesymbol_syn
Nzf1
resolver
uniprot
A0A5H1ZRT6
resolver
uniprot
A0A8I6A056
resolver
uniprot
D4A9W2
resolver
uniprot
P70589
resolver
uniprot_entry
A0A5H1ZRT6_RAT
resolver
uniprot_entry
A0A8I6A056_RAT
resolver
uniprot_entry
MYT1L_RAT
resolver
uniprot_sec
D4A9W2
resolver
uniprot_sec
P70589
resolver
amino_acid_sequence
MDVDAEEKRHRTRSKGVRVPVEPAIQELFSCPTPGCDGSGHVSGKYARHRSVYGCPLAKKRKTQDKQPQEPAPKRKPFAVKADSSSVDECYESDGTEDMDDKEEDDDEEFSEDNDEQGDDDDEDEVDREDEEEIEEEDDEDDEDDDDGDDVEEEEDDDDEEEEEEEEEEENEDHQMSCTRIMQDPEKDDNNNDEYDNYDELVAKSLLNLGKIAEDAAYRARTESEMNSNTSNSLEDDSDKNENLGRKSELSLDLDSDVVRETVDSLKLLAQGHGVVLSENISDRSYAEGMSQQDSRNMNYVMLGKPMNNGLMEKMVEESDEEVCLSSLECLRNQCFDLARKLSETNPQDRSQPPNMSVRQHVRQEDDFPGRTPDRSYSDMMNLMRLEEQLSPRSRTFSSCAKEDGCHERDDDTTSVNSDRSEEVFDMTKGNLTLLEKAIALETERAKAMREKMAMDAGRRDNLRSYEDQSPRQLAGEDRKSKSSDSHVKKPYYDPSRTEKRESKCPTPGCDGTGHVTGLYPHHRSLSGCPHKDRVPPEILAMHENVLKCPTPGCTGRGHVNSNRNSHRSLSGCPIAAAEKLAKAQEKHQSCDVSKSNQASDRVLRPMCFVKQLEIPQYGYRNNVPTTTPRSNLAKELEKYSKTSFEYNSYDNHTYGKRAIAPKVQTRDISPKGYDDAKRYCKNASPSSSTTSSYAPSSSSNLSCGGGSSASSTCSKSSFDYTHDMEAAHMAATAILNLSTRCREMPQNLSTKPQDLCTARNPDMEVDENGTLDLSMNKQRPRDSCCPVLTPLEPMSPQQQAVMSSRCFQLSEGDCWDLPVDYTKMKPRRVDEEDPKEITPEDLDPFQEALEERRYPGEVTIPSPKPKYPQCKESKKDLITLSGCPLADKSIRSMLATSSQELKCPTPGCDGSGHITGNYASHRSLSGCPRAKKSGIRIAQSKEDKEDQEPIRCPVPGCDGQGHITGKYASHRSASGCPLAAKRQKDGYLNGSQFSWKSVKTEGMSCPTPGCDGSGHVSGSFLTHRSLSGCPRATSAMKKAKLSGEQMLTIKQRASNGIENDEEIKQLDEEIKELNESNSQMEADMIKLRTQVTITTMESNLKTIEEENKVIEQQNESLLHELANLSQSLIHSLANIQLPHMDPINEQNFDAYVTTLTEMYTNQDRYQSPENKALLENIKQAVRGIQV
uniprot
proteins
function
FUNCTION: Transcription factor that plays a key role in neuronal differentiation (PubMed:9373037). Acts by specifically repressing expression of non-neuronal genes during neuron differentiation (By similarity). In contrast to other transcription repressors that inhibit specific lineages, mediates repression of multiple differentiation programs (By similarity). Also represses expression of negative regulators of neurogenesis, such as members of the Notch signaling pathway, including HES1 (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (By similarity). Directly binds the 5'-AAGTT-3' core motif present on the promoter of target genes and represses transcription by recruiting a multiprotein complex containing SIN3B (By similarity). The 5'-AAGTT-3' core motif is absent from the promoter of neural genes (By similarity). {ECO:0000250|UniProtKB:P97500, ECO:0000269|PubMed:9373037}.
uniprot
proteins
mass_dalton
132926
uniprot
proteins
protein_family
MYT1 family
uniprot
proteins
pubmed
14744132
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
8631881
uniprot
proteins
pubmed
8980226
uniprot
proteins
pubmed
9373037
uniprot
proteins
sequence_length
1187
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9373037}. Chromosome {ECO:0000250|UniProtKB:P97500}. Note=Preferentially binds to DNA binding sites that are in an open chromatin configuration. {ECO:0000250|UniProtKB:P97500}.
uniprot
proteins