Tmem147
entrez
69804
canonical
uniprot
Q9CQG6
canonical
ensembl
ENSMUSG00000006315
resolver
ensp
ENSMUSP00000006478
resolver
ensp
ENSMUSP00000146918
resolver
enst
ENSMUST00000209065
resolver
genesymbol
Tmem147
resolver
uniprot
A0A140LIQ8
resolver
uniprot
B2RVQ1
resolver
uniprot
Q8CI89
resolver
uniprot
Q9D8F0
resolver
uniprot_entry
A0A140LIQ8_MOUSE
resolver
uniprot_entry
B2RVQ1_MOUSE
resolver
uniprot_entry
TM147_MOUSE
resolver
uniprot_sec
Q8CI89
resolver
uniprot_sec
Q9D8F0
resolver
amino_acid_sequence
MTLFHFGNCFALAYFPYFITYKCSGLSEYNAFWKCVQAGVTYLFVQLCKMLFLATFFPTWEGGIYDFIGEFMKASVDVADLIGLNLVMSRNAGKGEYKIMVAALGWATAELIMSRCIPLWVGARGIEFDWKYIQMSIDSNISLVHYIVASAQVWMITRYDLYHTFRPAVLLLMFLSVYKAFVMETFVHLFSLGSWTALLARAVVTGLLALSTLALYVAVVNVHS
uniprot
proteins
function
FUNCTION: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes. The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions. Also acts as a negative regulator of CHRM3 function, most likely by interfering with its trafficking to the cell membrane. Negatively regulates CHRM3-mediated calcium mobilization and activation of RPS6KA1/p90RSK activity. Regulates LBR localization to the nucleus inner membrane. {ECO:0000250|UniProtKB:Q9BVK8}.
uniprot
proteins
mass_dalton
25335
uniprot
proteins
protein_family
TMEM147 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21056967
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
224
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9BVK8}; Multi-pass membrane protein {ECO:0000255}. Nucleus membrane {ECO:0000250|UniProtKB:Q9BVK8}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:I6VSD2}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 1..21; /note="Helical"; /evidence="ECO:0000250|UniProtKB:A0A8I3MKU8"; TRANSMEM 35..58; /note="Helical"; /evidence="ECO:0000250|UniProtKB:A0A8I3MKU8"; TRANSMEM 67..88; /note="Helical"; /evidence="ECO:0000250|UniProtKB:A0A8I3MKU8"; TRANSMEM 99..124; /note="Helical"; /evidence="ECO:0000250|UniProtKB:A0A8I3MKU8"; TRANSMEM 130..155; /note="Helical"; /evidence="ECO:0000250|UniProtKB:A0A8I3MKU8"; TRANSMEM 165..187; /note="Helical"; /evidence="ECO:0000250|UniProtKB:A0A8I3MKU8"; TRANSMEM 195..216; /note="Helical"; /evidence="ECO:0000250|UniProtKB:A0A8I3MKU8
uniprot
proteins