Sh3glb1
entrez
54673
canonical
uniprot
Q9JK48
canonical
ensembl
ENSMUSG00000037062
resolver
ensp
ENSMUSP00000129800
resolver
ensp
ENSMUSP00000142716
resolver
ensp
ENSMUSP00000143312
resolver
ensp
ENSMUSP00000143433
resolver
ensp
ENSMUSP00000207086
resolver
ensp
ENSMUSP00000207093
resolver
genesymbol
Sh3glb1
resolver
genesymbol_syn
Kiaa0491
resolver
uniprot
Q3TYR7
resolver
uniprot
Q6A059
resolver
uniprot
Q8CDS9
resolver
uniprot
Q8VI52
resolver
uniprot
Q9CT31
resolver
uniprot_entry
SHLB1_MOUSE
resolver
uniprot_sec
Q3TYR7
resolver
uniprot_sec
Q6A059
resolver
uniprot_sec
Q8CDS9
resolver
uniprot_sec
Q8VI52
resolver
uniprot_sec
Q9CT31
resolver
amino_acid_sequence
MNIMDFNVKKLAADAGTFLSRAVQFTEEKLGQAEKTELDAHLENLLSKAECTKIWTEKIMKQTEVLLQPNPNARIEEFVYEKLDRKAPSRINNPELLGQYMIDAGTEFGPGTAYGNALIKCGETQKRIGTADRELIQTSALNFLTPLRNFIEGDYKTIAKERKLLQNKRLDLDAAKTRLKKAKAAETKSSSEQELRITQSEFDRQAEITRLLLEGISSTHAHHLRCLNDFVEAQMTYYAQCYQYMLDLQKQLGSFPSNYLSNNNQTSGTPVPYALSNAIGPSAQASTGSLVITCPSNLNDLKESSNNRKARVLYDYDAANSTELSLLADEVITVFSVVGMDSDWLMGERGNQKGKVPITYLELLN
uniprot
proteins
function
FUNCTION: May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells (PubMed:17086176). May recruit other proteins to membranes with high curvature. May promote membrane fusion (By similarity). Involved in activation of caspase-dependent apoptosis by promoting BAX/BAK1 activation (PubMed:16227588). Isoform 1 acts proapoptotic in fibroblasts (PubMed:24523556). Involved in caspase-independent apoptosis during nutrition starvation and involved in the regulation of autophagy. Activates lipid kinase activity of PIK3C3 during autophagy probably by associating with the PI3K complex II (PI3KC3-C2). Associated with PI3KC3-C2 during autophagy may regulate the trafficking of ATG9A from the Golgi complex to the peripheral cytoplasm for the formation of autophagosomes by inducing Golgi membrane tubulation and fragmentation. Involved in regulation of degradative endocytic trafficking and cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Isoform 2 acts antiapoptotic in neuronal cells; involved in maintenance of mitochondrial morphology and promotes neuronal viability (PubMed:24523556). {ECO:0000250|UniProtKB:Q9Y371, ECO:0000269|PubMed:17086176, ECO:0000269|PubMed:24523556}.
uniprot
proteins
mass_dalton
40855
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Thr-145 by CDK5; this phosphorylation is required for autophagy induction in starved neurons and facilitates homodimerization. {ECO:0000250}.
uniprot
proteins
protein_family
Endophilin family
uniprot
proteins
pubmed
12456676
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16227588
uniprot
proteins
pubmed
17086176
uniprot
proteins
pubmed
17381077
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24523556
uniprot
proteins
sequence_length
365
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17381077}. Golgi apparatus membrane {ECO:0000269|PubMed:17086176}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6AYE2}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9Y371}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9Y371}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:Q9Y371}. Midbody {ECO:0000250|UniProtKB:Q9Y371}. Note=Association with the Golgi apparatus depends on the cell type. Following starvation colocalizes with ATG5 and LC3 autophagy-related protein(s)on autophagosomal membranes. {ECO:0000250|UniProtKB:Q9Y371}.
uniprot
proteins