Aldh1a1
entrez
24188
canonical
uniprot
P51647
canonical
ensembl
ENSRNOG00000017619
resolver
ensp
ENSRNOP00000024000
resolver
ensp
ENSRNOP00000090793
resolver
enst
ENSRNOT00000112107
resolver
genesymbol
Aldh1a1
resolver
genesymbol_syn
Aldh
resolver
uniprot
A0A8I6AP49
resolver
uniprot
O09184
resolver
uniprot_entry
A0A8I6AP49_RAT
resolver
uniprot_entry
AL1A1_RAT
resolver
uniprot_sec
O09184
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by chloral hydrate. {ECO:0000269|PubMed:7832787}.
uniprot
proteins
amino_acid_sequence
MSSPAQPAVPAPLANLKIQHTKIFINNEWHDSVSGKKFPVLNPATEEVICHVEEGDKADVDKAVKAARQAFQIGSPWRTMDASERGRLLNKLADLMERDRLLLATIEAINGGKVFANAYLSDLGGSIKALKYCAGWADKIHGQTIPSDGDIFTFTRREPIGVCGQIIPWNFPLLMFIWKIGPALSCGNTVVVKPAEQTPLTALHMASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDVDKVAFTGSTQVGKLIKEAAGKSNLKRVTLELGGKSPCIVFADADLDIAVEFAHHGVFYHQGQCCVAASRIFVEESVYDEFVRKSVERAKKYVLGNPLTQGINQGPQIDKEQHDKILDLIESGKKEGAKLECGGGRWGNKGFFVQPTVFSNVTDEMRIAKEEIFGPVQQIMKFKSIDDVIKRANNTTYGLAAGVFTKDLDRAITVSSALQAGVVWVNCYMILSAQCPFGGFKMSGNGRELGEHGLYEYTELKTVAMKISQKNS
uniprot
proteins
ec_number
1.2.1.19
uniprot
proteins
ec_number
1.2.1.28
uniprot
proteins
ec_number
1.2.1.3
uniprot
proteins
ec_number
1.2.1.36
uniprot
proteins
function
FUNCTION: Cytosolic dehydrogenase that catalyzes the NAD(+)-dependent irreversible oxidation of a wide range of aldehydes to their corresponding carboxylic acid (PubMed:15623782, PubMed:7832787). Functions downstream of retinol dehydrogenases and catalyzes the oxidation of retinaldehyde into retinoic acid, the second step in the oxidation of retinol/vitamin A into retinoic acid. This pathway is crucial to control the levels of retinol and retinoic acid, two important molecules which excess can be teratogenic and cytotoxic (PubMed:7832787). Also oxidizes aldehydes resulting from lipid peroxidation like (E)-4-hydroxynon-2-enal/HNE, malonaldehyde and hexanal that form protein adducts and are highly cytotoxic. By participating for instance to the clearance of (E)-4-hydroxynon-2-enal/HNE in the lens epithelium prevents the formation of HNE-protein adducts and lens opacification (PubMed:15623782). Functions also downstream of fructosamine-3-kinase in the fructosamine degradation pathway by catalyzing the oxidation of 3-deoxyglucosone, the carbohydrate product of fructosamine 3-phosphate decomposition, which is itself a potent glycating agent that may react with lysine and arginine side-chains of proteins (By similarity). Also has an aminobutyraldehyde dehydrogenase activity and is probably part of an alternative pathway for the biosynthesis of GABA/4-aminobutanoate in midbrain, thereby playing a role in GABAergic synaptic transmission (By similarity). {ECO:0000250|UniProtKB:P00352, ECO:0000250|UniProtKB:P24549, ECO:0000269|PubMed:15623782, ECO:0000269|PubMed:7832787}.
uniprot
proteins
mass_dalton
54459
uniprot
proteins
pathway_participation
PATHWAY: Cofactor metabolism; retinol metabolism. {ECO:0000269|PubMed:7832787}.
uniprot
proteins
post_translational_modification
PTM: The N-terminus is blocked most probably by acetylation. {ECO:0000305|PubMed:7832787}.
uniprot
proteins
protein_family
Aldehyde dehydrogenase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15623782
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7832787
uniprot
proteins
pubmed
8543180
uniprot
proteins
pubmed
9059608
uniprot
proteins
pubmed
9218716
uniprot
proteins
pubmed
9240474
uniprot
proteins
sequence_length
501
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P00352}. Cell projection, axon {ECO:0000250|UniProtKB:P24549}.
uniprot
proteins