Cenps
entrez
69928
canonical
uniprot
Q9D084
canonical
ensembl
ENSMUSG00000073705
resolver
ensp
ENSMUSP00000030813
resolver
genesymbol
Cenps
resolver
genesymbol_syn
Apitd1
resolver
genesymbol_syn
FAAP16
resolver
genesymbol_syn
MHF1
resolver
uniprot
A2AH77
resolver
uniprot
Q80ZS2
resolver
uniprot
Q8BH28
resolver
uniprot_entry
CENPS_MOUSE
resolver
uniprot_sec
A2AH77
resolver
uniprot_sec
Q80ZS2
resolver
uniprot_sec
Q8BH28
resolver
amino_acid_sequence
MEEVEAEEPQEFSHRQRLKAAVHYTVGCLCQEVTLNKQVNFSKQTIAAISEVTFRQCENFAKDLEMFARHAKRSTVTTEDVKLLARRNNSLLKYITEKNEEIAQLNLKGKAKKKRKPEDESRSSRESMAEELDGAEELQSES
uniprot
proteins
function
FUNCTION: DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPX (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPX and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked replication forks. In complex with CENPT, CENPW and CENPX (CENP-T-W-S-X heterotetramer), involved in the formation of a functional kinetochore outer plate, which is essential for kinetochore-microtubule attachment and faithful mitotic progression. As a component of MHF and CENP-T-W-S-X complexes, binds DNA and bends it to form a nucleosome-like structure. DNA-binding function is fulfilled in the presence of CENPX, with the following preference for DNA substates: Holliday junction > double-stranded > splay arm > single-stranded. Does not bind DNA on its own. {ECO:0000250|UniProtKB:Q8N2Z9}.
uniprot
proteins
mass_dalton
16335
uniprot
proteins
protein_family
CENP-S/MHF1 subfamily
uniprot
proteins
protein_family
TAF9 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
142
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8N2Z9}. Chromosome, centromere {ECO:0000250|UniProtKB:Q8N2Z9}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q8N2Z9}. Note=Assembly of CENPS and CENPX and its partner subunits CENPT and CENPW at centromeres occurs through a dynamic exchange mechanism. Although exchange is continuous in the cell cycle, de novo assembly starts principally during mid-late S phase and is complete by G2. CENPS is more stably bound at the kinetochore than CENPX. During S phase, rapidly recruited to DNA interstrand cross-links that block replication. Recruited to DNA damage sites about 20 minutes following UV irradiation, reaching a plateau after approximately 40 minutes. {ECO:0000250|UniProtKB:Q8N2Z9}.
uniprot
proteins