Aplnr
entrez
23796
canonical
uniprot
Q9WV08
canonical
ensembl
ENSMUSG00000044338
resolver
ensp
ENSMUSP00000053638
resolver
enst
ENSMUST00000057019
resolver
genesymbol
Aplnr
resolver
genesymbol_syn
Agtrl1
resolver
genesymbol_syn
Apj
resolver
uniprot
Q3TZS9
resolver
uniprot_entry
APJ_MOUSE
resolver
uniprot_sec
Q3TZS9
resolver
amino_acid_sequence
MEDDGYNYYGADNQSECDYADWKPSGALIPAIYMLVFLLGTTGNGLVLWTVFRTSREKRRSADIFIASLAVADLTFVVTLPLWATYTYREFDWPFGTFSCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAVPVMVFRSTDASENGTKIQCYMDYSMVATSNSEWAWEVGLGVSSTAVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDIFLMNVFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCDQSGCKGTPHSSSAEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVD
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for peptide hormones apelin (APLN) and apelin receptor early endogenous ligand (APELA), that plays a role in the regulation of normal cardiovascular function and fluid homeostasis (PubMed:22810587, PubMed:28663440, PubMed:28854362, PubMed:28890073). When acting as apelin receptor, activates both G(i) protein pathway that inhibits adenylate cyclase activity, and the beta-arrestin pathway leading to internalization of the receptor (PubMed:22810587, PubMed:28663440, PubMed:28854362, PubMed:28890073). APLNR/APJ receptor is also activated by mechanical strech in a G-protein-independent fashion to induce beta-arrestin signaling leading to cardiac hypertrophy (PubMed:22810587). However, the presence of apelin ligand blunts cardiac hypertrophic induction from APLNR/APJ on response to pathological stimuli (PubMed:22810587). Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone (PubMed:28663440, PubMed:28854362, PubMed:28890073). May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity). Promotes sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel development (PubMed:28890073). Also plays a role in various processes in adults such as regulation of blood vessel formation, blood pressure and heart contractility and protection from cardiac hypertrophy and heart failure (PubMed:22810587, PubMed:28371822). {ECO:0000250|UniProtKB:Q7SZP9, ECO:0000269|PubMed:22810587, ECO:0000269|PubMed:28371822, ECO:0000269|PubMed:28663440, ECO:0000269|PubMed:28854362, ECO:0000269|PubMed:28890073}.
uniprot
proteins
mass_dalton
42266
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10473142
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
22810587
uniprot
proteins
pubmed
26611206
uniprot
proteins
pubmed
28371822
uniprot
proteins
pubmed
28663440
uniprot
proteins
pubmed
28854362
uniprot
proteins
pubmed
28890073
uniprot
proteins
sequence_length
377
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P35414}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P79960}. Note=After exposure to apelin (APLN) or apelin receptor early endogenous ligand (APELA), internalized from the cell surface into an endosomal recycling compartment, from where it is recycled to the cell membrane. {ECO:0000250|UniProtKB:P35414, ECO:0000250|UniProtKB:Q9JHG3}.
uniprot
proteins
transmembrane_region
TRANSMEM 29..52; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P35414"; TRANSMEM 63..84; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P35414"; TRANSMEM 98..123; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P35414"; TRANSMEM 145..162; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P35414"; TRANSMEM 197..221; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P35414"; TRANSMEM 245..268; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P35414"; TRANSMEM 288..310; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P35414
uniprot
proteins