Fgfr4
entrez
14186
canonical
uniprot
Q03142
canonical
ensembl
ENSMUSG00000005320
resolver
ensp
ENSMUSP00000005452
resolver
enst
ENSMUST00000005452
resolver
genesymbol
Fgfr4
resolver
genesymbol_syn
Fgfr-4
resolver
genesymbol_syn
Mpk-11
resolver
uniprot
A0A0R4IZY3
resolver
uniprot
Q27Q87
resolver
uniprot
Q5J7D9
resolver
uniprot
Q8C3V5
resolver
uniprot
Q8CIB8
resolver
uniprot_entry
A0A0R4IZY3_MOUSE
resolver
uniprot_entry
FGFR4_MOUSE
resolver
uniprot_sec
Q27Q87
resolver
uniprot_sec
Q5J7D9
resolver
uniprot_sec
Q8C3V5
resolver
uniprot_sec
Q8CIB8
resolver
activity_regulation
ACTIVITY REGULATION: Present in an inactive conformation in the absence of bound ligand. Ligand binding leads to dimerization and activation by autophosphorylation on tyrosine residues (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MWLLLALLSIFQGTPALSLEASEEMEQEPCLAPILEQQEQVLTVALGQPVRLCCGRTERGRHWYKEGSRLASAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMTVVHNLTLLMDDSLTSISNDEDPKTLSSSSSGHVYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPMPTIHWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENSLGSIRYSYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHVVINGSSFGADGFPYVQVLKTTDINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDLTWTTATPEARYTDIILYVSGSLVLLVLLLLAGVYHRQVIRGHYSRQPVTIQKLSRFPLARQFSLESRSSGKSSLSLVRGVRLSSSGPPLLTGLVNLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVVRAEAFGMDPSRPDQTSTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPALVSCAYQVARGMQYLESRKCIHRDLAARNVLVTEDDVMKIADFGLARGVHHIDYYKKTSNGRLPVKWMAPEALFDRVYTHQSDVWSFEILLWEIFTLGGSPYPGIPVEELFSLLREGHRMERPPNCPSELYGLMRECWHAAPSQRPTFKQLVEALDKVLLAVSEEYLDLRLTFGPFSPSNGDASSTCSSSDSVFSHDPLPLEPSPFPFSDSQTT
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Plays a role in postnatal lung development. May be involved in the development of skeletal muscle cell lineages. {ECO:0000269|PubMed:10809780, ECO:0000269|PubMed:17664243, ECO:0000269|PubMed:19237543, ECO:0000269|PubMed:21561999, ECO:0000269|PubMed:9716527}.
uniprot
proteins
mass_dalton
88661
uniprot
proteins
mutagenesis
MUTAGEN 385; /note="G->R: Results in increased cell proliferation. Results in STAT3 phosphorylation and signaling activation."; /evidence="ECO:0000269|PubMed:26675719
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. Isoform 1 and isoform 2 are glycosylated. Full maturation of the glycan chains in the Golgi is essential for high affinity interaction with FGF19 (By similarity). {ECO:0000250}.; PTM: Ubiquitinated. Subject to proteasomal degradation when not fully glycosylated (By similarity). {ECO:0000250}.; PTM: Autophosphorylated. Binding of FGF family members together with heparan sulfate proteoglycan or heparin promotes receptor dimerization and autophosphorylation on tyrosine residues. Autophosphorylation occurs in trans between the two FGFR molecules present in the dimer. Isoform 1 and isoform 2 are phosphorylated on tyrosine residues (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Fibroblast growth factor receptor subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
10809780
uniprot
proteins
pubmed
1281307
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1723680
uniprot
proteins
pubmed
17452648
uniprot
proteins
pubmed
17664243
uniprot
proteins
pubmed
18186042
uniprot
proteins
pubmed
19237543
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
21561999
uniprot
proteins
pubmed
26675719
uniprot
proteins
pubmed
9716527
uniprot
proteins
sequence_length
799
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18186042}; Single-pass type I membrane protein {ECO:0000269|PubMed:18186042}. Endosome {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Note=Internalized from the cell membrane to recycling endosomes, and from there back to the cell membrane. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 367..387; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins