Samtor
entrez
101148
canonical
uniprot
Q8BXK4
canonical
ensembl
ENSMUSG00000042742
resolver
ensp
ENSMUSP00000040578
resolver
enst
ENSMUST00000045235
resolver
genesymbol
Samtor
resolver
genesymbol_syn
Bmt2
resolver
uniprot
A6H608
resolver
uniprot_entry
SAMTR_MOUSE
resolver
uniprot_sec
A6H608
resolver
amino_acid_sequence
MEPGPGGRGAARGQRPPNAAQPREQERKLEQEKLSGVVKSVHRRLRKKYREVGDFDKIWREHCEDAETLCEYAVAMKNLADNHWAKTCEGEGRIEWCCSVCREYFQNGGKRKALEKDEKRAVLATKTTPALNVHESSKLEGPLTNLSFTSPDFITELLQASGKIRLLDVGSCFNPFLKFEEFLTVGIDIVPAVESVYKCDFLNLQLQQPLQLAQDAIDAFLKQLRNPIDALPGELFHVVVFSLLLSYFPSPYQRWICCKKAHELLVLNGLLLIITPDSSHQNRHAMMMKSWKIAIESLGFKRFKYSKFSHMHLMAFRKTSLKTTSDLVSRNYPGMLYIPQDFNSVEEEEYSNTSCYVRSDLEDEQLAYGFTELPEAPYDSDSGESQASSIPFYELEDPILLLS
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase. {ECO:0000255|HAMAP-Rule:MF_03044}.
uniprot
proteins
mass_dalton
45952
uniprot
proteins
protein_family
BMT2/SAMTOR family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
403
uniprot
proteins