INSC
entrez
387755
canonical
uniprot
Q1MX18
canonical
ensembl
ENSG00000188487
resolver
ensp
ENSP00000368872
resolver
ensp
ENSP00000368874
resolver
ensp
ENSP00000389161
resolver
ensp
ENSP00000435022
resolver
ensp
ENSP00000436113
resolver
ensp
ENSP00000436194
resolver
ensp
ENSP00000546249
resolver
ensp
ENSP00000682355
resolver
genesymbol
INSC
resolver
hgnc
HGNC:33116
resolver
uniprot
A0PJX5
resolver
uniprot
Q1MX19
resolver
uniprot
Q3C1V6
resolver
uniprot
Q4AC95
resolver
uniprot
Q4AC96
resolver
uniprot
Q4AC97
resolver
uniprot
Q4AC98
resolver
uniprot_entry
INSC_HUMAN
resolver
uniprot_sec
A0PJX5
resolver
uniprot_sec
Q1MX19
resolver
uniprot_sec
Q3C1V6
resolver
uniprot_sec
Q4AC95
resolver
uniprot_sec
Q4AC96
resolver
uniprot_sec
Q4AC97
resolver
uniprot_sec
Q4AC98
resolver
amino_acid_sequence
MRRPPGNGEAASEGPGGWGLWGVQESRRLCCAGHDRCKQALLQIGINMMALPGGRHLDSVTLPGQRLHLMQVDSVQRWMEDLKLMTECECMCVLQAKPISLEEDAQGDLILAGGPGPGDPLQLLLKRGWVISTELRRIGQKLAQDRWARVHSMSVRLTCHARSMVSEYSAVSRNSLKEMGEIEKLLMEKCSELSAVTERCLQVENEHVLKSMKACVSETLSMLGQHFGQLLELALTREVQALVRKIDASDNIYTTESTTGNLFSLTQEGAPLCRIIAKEGGVVALFKVCRQDSFRCLYPQALRTLASICCVEEGVHQLEKVDGVLCLADILTDNSHSEATRAEAAAVVAQVTSPHLPVTQHLSSFLESMEEIVTALVKLCQEASSGEVFLLASAALANITFFDTMACEMLLQLNAIRVLLEACSDKQRVDTPYTRDQIVTILANMSVLEQCASDIIQENGVQLIMGMLSEKPRSGTPAEVAACERVQQKAAVTLARLSRDPDVAREAVRLSCMSRLIELCRSPSERNSSDAVLVACLAALRRLAGVCPEGLQDSDFQQLVQPRLVDSFLLCSNMEESFV
uniprot
proteins
function
FUNCTION: May function as an adapter linking the Par3 complex to the GPSM1/GPSM2 complex (PubMed:16458856). Involved in spindle orientation during mitosis. May regulate cell proliferation and differentiation in the developing nervous system. May play a role in the asymmetric division of fibroblasts and participate in the process of stratification of the squamous epithelium (By similarity). {ECO:0000250|UniProtKB:Q3HNM7, ECO:0000305|PubMed:16458856}.
uniprot
proteins
mass_dalton
63469
uniprot
proteins
mutagenesis
MUTAGEN 78; /note="W->A: Abolishes interaction with GPSM2."; /evidence="ECO:0000269|PubMed:22074847"; MUTAGEN 89; /note="E->R: Strongly reduces interaction with GPSM2. Abolishes interaction with GPSM2 and GPSM1; when associated with D-97."; /evidence="ECO:0000269|PubMed:22074847"; MUTAGEN 97; /note="K->D: Abolishes interaction with GPSM2 and GPSM1; when associated with R-89."; /evidence="ECO:0000269|PubMed:22074847
uniprot
proteins
pubmed
12469229
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16458856
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
22074847
uniprot
proteins
sequence_length
579
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22074847}. Cytoplasm, cell cortex {ECO:0000269|PubMed:22074847}. Note=Uniformly distributed in the cytoplasm during interphase. During metaphase, detected in the cell cortex, adjacent to the mitotic spindle poles. {ECO:0000269|PubMed:22074847}.
uniprot
proteins