Naxe
entrez
246703
canonical
uniprot
Q8K4Z3
canonical
ensembl
ENSMUSG00000028070
resolver
ensp
ENSMUSP00000029708
resolver
ensp
ENSMUSP00000165120
resolver
ensp
ENSMUSP00000165122
resolver
ensp
ENSMUSP00000165125
resolver
ensp
ENSMUSP00000165130
resolver
ensp
ENSMUSP00000165131
resolver
ensp
ENSMUSP00000333750
resolver
ensp
ENSMUSP00000359698
resolver
enst
ENSMUST00000029708
resolver
genesymbol
Naxe
resolver
genesymbol_syn
Aibp
resolver
genesymbol_syn
Apoa1bp
resolver
uniprot_entry
NNRE_MOUSE
resolver
amino_acid_sequence
MSGLRTLLGLGLLVAGSRLPRVISQQSVCRARPIWWGTQRRGSETMAGAAVKYLSQEEAQAVDQELFNEYQFSVDQLMELAGLSCATAIAKAYPPTSMSKSPPTVLVICGPGNNGGDGLVCARHLKLFGYQPTIYYPKRPNKPLFTGLVTQCQKMDIPFLGEMPPEPMMVDELYELVVDAIFGFSFKGDVREPFHSILSVLSGLTVPIASIDIPSGWDVEKGNPSGIQPDLLISLTAPKKSATHFTGRYHYLGGRFVPPALEKKYQLNLPSYPDTECVYRLQ
uniprot
proteins
ec_number
5.1.99.6
uniprot
proteins
function
FUNCTION: Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) (PubMed:21994945). This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity). Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis (By similarity). {ECO:0000250|UniProtKB:Q8NCW5, ECO:0000255|HAMAP-Rule:MF_03159, ECO:0000269|PubMed:21994945}.
uniprot
proteins
mass_dalton
30973
uniprot
proteins
post_translational_modification
PTM: Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation. {ECO:0000255|HAMAP-Rule:MF_03159, ECO:0000269|PubMed:18202122}.
uniprot
proteins
protein_family
NnrE/AIBP family
uniprot
proteins
pubmed
11991719
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18202122
uniprot
proteins
pubmed
18614015
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21994945
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
282
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03159}. Secreted {ECO:0000255|HAMAP-Rule:MF_03159, ECO:0000269|PubMed:18202122, ECO:0000269|PubMed:18614015}. Note=In sperm, secretion gradually increases during capacitation.
uniprot
proteins