Slc18a2
entrez
214084
canonical
uniprot
Q8BRU6
canonical
ensembl
ENSMUSG00000025094
resolver
ensp
ENSMUSP00000026084
resolver
enst
ENSMUST00000026084
resolver
genesymbol
Slc18a2
resolver
genesymbol_syn
Vmat2
resolver
uniprot
Q8CC55
resolver
uniprot_entry
VMAT2_MOUSE
resolver
uniprot_sec
Q8CC55
resolver
activity_regulation
ACTIVITY REGULATION: Strongly inhibited by reserpine and tetrabenazine (By similarity). Also inhibited to a lesser extent by ketanserin and fenfluramine (By similarity). Reserpine and ketanserin inhibit by blocking the substrate-binding pocket (By similarity). Tetrabenazine traps SLC18A2/VMAT2 in an occluded conformation and its inhibition is specific to SLC18A2/VMAT2 but not SLC18A1/VMAT1 (By similarity). {ECO:0000250|UniProtKB:Q05940}.
uniprot
proteins
amino_acid_sequence
MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPIIPSYLYSIKHEKNTTEIQTARPALTASTSESFHSIFSYYNNSTVFTGNATGGLPGGESPKATTTQHTVTNTTVPPDCPSEDKDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIGYPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDEERGNAMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPSRVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLGVAFLPASISYLIGTNIFGILAHKMGRWLCALLGMIVVGISILCIPFAKNIYGLIAPNFGVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAIGFPWLMTIIGIIDIVFAPLCFFLRSPPAKEEKMAILMDHNCPIKTKMYTQNNVQPYPVGDDEESESD
uniprot
proteins
function
FUNCTION: Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports a variety of catecholamines such as dopamine, adrenaline and noradrenaline, histamine, and indolamines such as serotonin (By similarity) (PubMed:10618388). Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates somatodendritic dopamine release in hippocampal neurons, likely as part of a regulated secretory pathway that integrates retrograde synaptic signals (By similarity). Acts as a primary transporter for striatal dopamine loading ensuring impulse-dependent release of dopamine at the synaptic cleft (PubMed:9427251). Responsible for histamine and serotonin storage and subsequent corelease from mast cell granules (By similarity) (PubMed:10618388). {ECO:0000250|UniProtKB:Q01827, ECO:0000269|PubMed:10618388, ECO:0000269|PubMed:9427251}.
uniprot
proteins
mass_dalton
55754
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Vesicular transporter family
uniprot
proteins
pubmed
10618388
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19357284
uniprot
proteins
pubmed
9427251
uniprot
proteins
sequence_length
517
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:9427251}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q01827}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:Q01827}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q01827}. Note=Sorted to large dense core granules in neuroendocrine cells, presumably at the level of the trans-Golgi network. In neurons it is predominantly detected in somatodendritic tubulovesicular membranes, a distinct population of secretory vesicles that undergo calcium-dependent exocytosis in axons and dendrites upon depolarization. Localized at synaptic vesicles in axons. {ECO:0000250|UniProtKB:Q01827}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..41; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q05940"; TRANSMEM 133..153; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q05940"; TRANSMEM 163..183; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q05940"; TRANSMEM 193..213; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q05940"; TRANSMEM 223..245; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q05940"; TRANSMEM 252..274; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q05940"; TRANSMEM 295..314; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q05940"; TRANSMEM 332..355; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q05940"; TRANSMEM 361..381; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q05940"; TRANSMEM 393..413; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q05940"; TRANSMEM 418..438; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q05940"; TRANSMEM 444..465; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:Q05940
uniprot
proteins