TLR3
entrez
7098
canonical
uniprot
O15455
canonical
ensembl
ENSG00000164342
resolver
ensp
ENSP00000296795
resolver
genesymbol
TLR3
resolver
hgnc
HGNC:11849
resolver
uniprot
B2RAI7
resolver
uniprot
B7Z7K0
resolver
uniprot
E6Y0F0
resolver
uniprot
E6Y0F1
resolver
uniprot
E9PGH4
resolver
uniprot
Q4VAL2
resolver
uniprot
Q504W0
resolver
uniprot_entry
TLR3_HUMAN
resolver
uniprot_sec
B2RAI7
resolver
uniprot_sec
B7Z7K0
resolver
uniprot_sec
E6Y0F0
resolver
uniprot_sec
E6Y0F1
resolver
uniprot_sec
E9PGH4
resolver
uniprot_sec
Q4VAL2
resolver
uniprot_sec
Q504W0
resolver
amino_acid_sequence
MRQTLPCIYFWGGLLPFGMLCASSTTKCTVSHEVADCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFNPFDCTCESIAWFVNWINETHTNIPELSSHYLCNTPPHYHGFPVRLFDTSSCKDSAPFELFFMINTSILLIFIFIVLLIHFEGWRISFYWNVSVHRVLGFKEIDRQTEQFEYAAYIIHAYKDKDWVWEHFSSMEKEDQSLKFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCKRFKVHHAVQQAIEQNLDSIILVFLEEIPDYKLNHALCLRRGMFKSHCILNWPVQKERIGAFRHKLQVALGSKNSVH
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency 83, susceptibility to viral infections (IMD83) [MIM:613002]: An immunologic disorder characterized by increased susceptibility to severe viral infections, including herpes simplex virus (HSV), varicella zoster virus (VZV), influenza A virus (IAV), hantavirus, and possibly respiratory syncytial virus (RSV). IMD83 clinical manifestations include acute infection-induced encephalitis and pneumonitis. The susceptibility to encephalitis or pneumonitis appears to result from impaired TLR3-dependent interferon production by nonhematopoietic cells that reside within the central nervous system or lung epithelial cells. IMD83 transmission pattern is consistent with autosomal dominant or autosomal recessive inheritance with incomplete penetrance. {ECO:0000269|PubMed:17872438}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response. {ECO:0000269|PubMed:12471095, ECO:0000269|PubMed:12539043, ECO:0000269|PubMed:16043704, ECO:0000269|PubMed:16144834, ECO:0000269|PubMed:16720699, ECO:0000269|PubMed:16858407, ECO:0000269|PubMed:17178723, ECO:0000269|PubMed:18172197, ECO:0000269|PubMed:22611194}.
uniprot
proteins
mass_dalton
103829
uniprot
proteins
mutagenesis
MUTAGEN 95; /note="C->A: Reduced response to ds-RNA."; /evidence="ECO:0000269|PubMed:16144834"; MUTAGEN 122; /note="C->A: Reduced response to ds-RNA."; /evidence="ECO:0000269|PubMed:16144834"; MUTAGEN 196; /note="N->G: Reduced expression levels; when associated with R-247."; /evidence="ECO:0000269|PubMed:16144834"; MUTAGEN 247; /note="N->R: Reduced response to ds-RNA. Reduced expression levels; when associated with G-196."; /evidence="ECO:0000269|PubMed:16144834"; MUTAGEN 539; /note="H->A: No effect."; /evidence="ECO:0000269|PubMed:16720699"; MUTAGEN 539; /note="H->E: Loss of RNA binding. Constitutive activation of NF-kappa-B."; /evidence="ECO:0000269|PubMed:16720699"; MUTAGEN 541; /note="N->A: Loss of RNA binding. Abolishes activation of NF-kappa-B."; /evidence="ECO:0000269|PubMed:16720699"; MUTAGEN 759; /note="Y->F: Reduced activation of NF-kappa-B in response to ds-RNA. Reduced induction of IL-8 in response to ds-RNA. Loss of interaction with WDFY1."; /evidence="ECO:0000269|PubMed:17178723, ECO:0000269|PubMed:25736436"; MUTAGEN 812; /note="K->R: Loss of ubiquitination by ZNRF1."; /evidence="ECO:0000269|PubMed:37158982"; MUTAGEN 831; /note="K->R: Loss of ubiquitination by TRIM3."; /evidence="ECO:0000269|PubMed:32878999"; MUTAGEN 858; /note="Y->F: Loss of interaction with WDFY1."; /evidence="ECO:0000269|PubMed:25736436
uniprot
proteins
post_translational_modification
PTM: Heavily N-glycosylated, except on that part of the surface of the ectodomain that is involved in ligand binding. {ECO:0000269|PubMed:15961631, ECO:0000269|PubMed:16043704, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:22579623}.; PTM: TLR3 signaling requires a proteolytic cleavage mediated by cathepsins CTSB and CTSH, the cleavage occurs between amino acids 252 and 346. The cleaved form of TLR3 is the predominant form found in endosomes. {ECO:0000269|PubMed:22611194}.; PTM: Ubiquitinated by TRIM3; leading to recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes (PubMed:32878999). Ubiquitinated by ZNRF1 via 'Lys-63'-linked ubiquitin chains; leading to TLR3 lysosomal trafficking and degradation (PubMed:37158982). Ubiquitinated by RNF170 at Lys-765 via 'Lys-48'-linked ubiquitin chains; leading to TLR3 proteasomal degradation (PubMed:31076723). {ECO:0000269|PubMed:31076723, ECO:0000269|PubMed:32878999, ECO:0000269|PubMed:37158982}.
uniprot
proteins
protein_family
Toll-like receptor family
uniprot
proteins
pubmed
12471095
uniprot
proteins
pubmed
12539043
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
15961631
uniprot
proteins
pubmed
16043704
uniprot
proteins
pubmed
16144834
uniprot
proteins
pubmed
16720699
uniprot
proteins
pubmed
16858407
uniprot
proteins
pubmed
17085778
uniprot
proteins
pubmed
17178723
uniprot
proteins
pubmed
17872438
uniprot
proteins
pubmed
18172197
uniprot
proteins
pubmed
18753640
uniprot
proteins
pubmed
18810425
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
22174453
uniprot
proteins
pubmed
22579623
uniprot
proteins
pubmed
22611194
uniprot
proteins
pubmed
25736436
uniprot
proteins
pubmed
31076723
uniprot
proteins
pubmed
32878999
uniprot
proteins
pubmed
32972995
uniprot
proteins
pubmed
33432245
uniprot
proteins
pubmed
37158982
uniprot
proteins
pubmed
9435236
uniprot
proteins
sequence_length
904
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane. Early endosome {ECO:0000269|PubMed:25736436}.
uniprot
proteins
transmembrane_region
TRANSMEM 705..725; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins