Creb3l1
entrez
362165
canonical
uniprot
Q66HA2
canonical
ensembl
ENSRNOG00000005413
resolver
ensp
ENSRNOP00000007771
resolver
enst
ENSRNOT00000007771
resolver
genesymbol
Creb3l1
resolver
genesymbol_syn
Oasis
resolver
uniprot
A0A8L2UHZ0
resolver
uniprot_entry
A0A8L2UHZ0_RAT
resolver
uniprot_entry
CR3L1_RAT
resolver
amino_acid_sequence
MDAVLEPFPADRLFPGSSFLDLGDLNESDFLNNAHFPEHLDHFVENMEDFSNDLFSSFFDDPVLDEKSPLLDMELDSPAPGIQAEHSYSLSGDSAPQSPLVPVKMEDTTQDMEHGAWALGNKLCSIMVKQEQSPELPVDPLAASSAMAAATMATPPLLGLSPISRLPIPHQAPGEMTQLPVIKAEPPEMSQFLKVTQEDLVQMPPTPPSSHGSDSDGSQSPRSLPPSSPVRPMARSSTAISTSPLLTAPHKLQGTSGPLLLTEEEKRTLIAEGYPIPTKLPLTKAEEKALKRVRRKIKNKISAQESRRKKKEYVECLEKKVETYTSENNELWKKVETLETANRTLLQQLQKLQTLVTSKISRPYKMAATQTGTCLMVAALCFVLVLGSLAPCLPAFSSGSKTVKEDPVAADSVYAASQMPSRSLLFYDDGAGSWEDGHRGALLPVEPPEGWELKPGGPAEPRPQDHLRHDHADSIHETTKYLRETWPEDTEDNGASPNFSHPKEWFHDRDLGPNTTIKLS
uniprot
proteins
function
FUNCTION: [Cyclic AMP-responsive element-binding protein 3-like protein 1]: Precursor of the transcription factor form (Processed cyclic AMP-responsive element-binding protein 3-like protein 1), which is embedded in the endoplasmic reticulum membrane with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress or DNA damage, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus where it activates transcription of specific target genes involved in the cell-cycle progression inhibition. {ECO:0000250|UniProtKB:Q9Z125}.; FUNCTION: [Processed cyclic AMP-responsive element-binding protein 3-like protein 1]: Transcription factor involved in cell type specific DNA damage and unfolded protein response (UPR) (By similarity). Binds the DNA consensus sequence 5'-GTGXGCXGC-3' (By similarity). Plays a critical role in bone formation through the transcription of COL1A1, and possibly COL1A2, and the secretion of bone matrix proteins. Directly binds to the UPR element (UPRE)-like sequence in an osteoblast-specific COL1A1 promoter region and induces its transcription. Does not regulate COL1A1 in other tissues, such as skin (By similarity). Required to protect astrocytes from ER stress-induced cell death. In astrocytes, binds to the cAMP response element (CRE) of the BiP/HSPA5 promoter and participate in its transcriptional activation. In astrocytes and osteoblasts, upon DNA damage, inhibits cell-cycle progression after G2/M phase by binding to promoters and activating transcription of genes encoding cell-cycle inhibitors, such as p21/CDKN1A (By similarity). Required for TGFB1 to activate genes involved in the assembly of collagen extracellular matrix (By similarity). {ECO:0000250|UniProtKB:Q96BA8, ECO:0000250|UniProtKB:Q9Z125}.
uniprot
proteins
mass_dalton
57134
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q9Z125}.; PTM: Ubiquitinated by HRD1/SYVN1; undergoes 'Lys-48'-linked ubiquitination, followed by rapid proteasomal degradation under normal conditions. Upon ER stress, SYVN1 E3 ubiquitin-protein ligase dissociates from its substrate, ubiquitination does not occur and CREB3L1 is stabilized. {ECO:0000250|UniProtKB:Q9Z125}.; PTM: Upon ER stress or DNA damage, translocated to the Golgi apparatus, where it is processed by regulated intramembrane proteolysis (RIP) to release the cytosol-facing N-terminal transcription factor domain. The cleavage is performed sequentially by site-1 and site-2 proteases (S1P/MBTPS1 and S2P/MBTPS2). RIP is induced by TGFB1 and ceramide. {ECO:0000250|UniProtKB:Q96BA8, ECO:0000250|UniProtKB:Q9Z125}.
uniprot
proteins
protein_family
ATF subfamily
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
520
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=ER membrane resident protein. Upon ER stress, translocated to the Golgi apparatus where it is cleaved. The cytosolic N-terminal fragment (processed cyclic AMP-responsive element-binding protein 3-like protein 1) is transported into the nucleus. {ECO:0000250|UniProtKB:Q9Z125}.; SUBCELLULAR LOCATION: [Processed cyclic AMP-responsive element-binding protein 3-like protein 1]: Nucleus {ECO:0000250|UniProtKB:Q9Z125}. Note=Upon ER stress or DNA damage, transported into the nucleus. {ECO:0000250|UniProtKB:Q9Z125}.
uniprot
proteins
transmembrane_region
TRANSMEM 376..396; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins