Mc3r
entrez
17201
canonical
uniprot
P33033
canonical
ensembl
ENSMUSG00000038537
resolver
ensp
ENSMUSP00000047358
resolver
enst
ENSMUST00000038532
resolver
genesymbol
Mc3r
resolver
uniprot
Q544G7
resolver
uniprot_entry
MC3R_MOUSE
resolver
uniprot_entry
Q544G7_MOUSE
resolver
amino_acid_sequence
MNSSCCLSSVSPMLPNLSEHPAAPPASNRSGSGFCEQVFIKPEVFLALGIVSLMENILVILAVVRNGNLHSPMYFFLCSLAAADMLVSLSNSLETIMIAVINSDSLTLEDQFIQHMDNIFDSMICISLVASICNLLAIAIDRYVTIFYALRYHSIMTVRKALTLIGVIWVCCGICGVMFIIYSESKMVIVCLITMFFAMVLLMGTLYIHMFLFARLHVQRIAVLPPAGVVAPQQHSCMKGAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTFKEILCGCNSMNLG
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for melanocyte-stimulating hormones (alpha, beta, and gamma-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor. Upon activation, couples to G(s) protein, stimulating adenylate cyclase and the cAMP-dependent signaling pathway, which contributes to the regulation of energy homeostasis (PubMed:8172596). Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain (PubMed:19036988). Binding of the Agouti-related protein/AGPR antagonist precludes alpha-MSH-induced signaling, blocking cAMP production (By similarity). {ECO:0000250|UniProtKB:P41968, ECO:0000269|PubMed:19036988, ECO:0000269|PubMed:8172596}.
uniprot
proteins
mass_dalton
35806
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
19036988
uniprot
proteins
pubmed
8172596
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 38..63; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 76..100; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 119..140; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 161..181; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 187..210; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 246..268; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 278..301; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins