Tnfaip1
entrez
21927
canonical
uniprot
O70479
canonical
ensembl
ENSMUSG00000017615
resolver
ensp
ENSMUSP00000017759
resolver
ensp
ENSMUSP00000103912
resolver
enst
ENSMUST00000017759
resolver
enst
ENSMUST00000108277
resolver
genesymbol
Tnfaip1
resolver
genesymbol_syn
Edp1
resolver
uniprot
Q3TH85
resolver
uniprot
Q3UGQ5
resolver
uniprot
Q8BV61
resolver
uniprot
Q8BZK5
resolver
uniprot_entry
BACD2_MOUSE
resolver
uniprot_sec
Q3TH85
resolver
uniprot_sec
Q3UGQ5
resolver
uniprot_sec
Q8BV61
resolver
uniprot_sec
Q8BZK5
resolver
amino_acid_sequence
MSGDTCLCPASGAKPKISGFKGGGLGNKYVQLNVGGSLYYTTVRALTRHDTMLKAMFSGRMEVLTDKEGWILIDRCGKHFGTILNYLRDDTITLPQSRQEIQELMAEAKYYLIQGLVSTCQTALQDKKDSYQPVCNIPIITSLREEDRLIESSTKPVVKLLYNRSNNKYSYTSNSDDHLLKNIELFDKLSLRFNGRVLFIKDVIGDEICCWSFYGQGRKLAEVCCTSIVYATEKKQTKVEFPEARIYEETLNVLLYETPRVPDNSLLEATSRSRSQASPSEDEDTFELRDRVRRIHVKRYSTYDDRQLGHQSTHRD
uniprot
proteins
function
FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
36134
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-280 by CK2 facilitates the nucleus localization and increases interaction with PCNA. {ECO:0000250}.
uniprot
proteins
protein_family
BACURD family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
9804998
uniprot
proteins
sequence_length
316
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Endosome {ECO:0000250}. Note=Colocalizes with RHOB in endosomes. {ECO:0000250}.
uniprot
proteins