Epn1
entrez
13854
canonical
uniprot
Q80VP1
canonical
ensembl
ENSMUSG00000035203
resolver
ensp
ENSMUSP00000043340
resolver
ensp
ENSMUSP00000096445
resolver
ensp
ENSMUSP00000146638
resolver
ensp
ENSMUSP00000189112
resolver
ensp
ENSMUSP00000189113
resolver
ensp
ENSMUSP00000189116
resolver
ensp
ENSMUSP00000189117
resolver
ensp
ENSMUSP00000189118
resolver
ensp
ENSMUSP00000189119
resolver
ensp
ENSMUSP00000189123
resolver
ensp
ENSMUSP00000189124
resolver
ensp
ENSMUSP00000189125
resolver
ensp
ENSMUSP00000189127
resolver
ensp
ENSMUSP00000189128
resolver
ensp
ENSMUSP00000189130
resolver
ensp
ENSMUSP00000189133
resolver
ensp
ENSMUSP00000189135
resolver
ensp
ENSMUSP00000189138
resolver
ensp
ENSMUSP00000189144
resolver
ensp
ENSMUSP00000189146
resolver
ensp
ENSMUSP00000189148
resolver
genesymbol
Epn1
resolver
uniprot
O70446
resolver
uniprot
Q6NX78
resolver
uniprot_entry
EPN1_MOUSE
resolver
uniprot_sec
O70446
resolver
uniprot_sec
Q6NX78
resolver
amino_acid_sequence
MSTSSLRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQGVNVREKAKQLVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQSSGEEELQLQLALAMSKEEADQPPSCGPEDDVQLQLALSLSREEHDKEERIRRGDDLRLQMAIEESKRETGGKEESSLMDLADVFTTPAPPQASDPWGGPASVPTAVPVAAAASDPWGGPAVPPAADPWGGAAPTPASGDPWRPAAPTGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGAPVSGPPSSDPWAPAPAFSDPWGGSPAKPSSNGTAVGGFDTEPDEFSDFDRLRTALPTSGSSTGELELLAGEVPARSPGAFDMSGVGGSLAESVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGSKASNPFLPSGAPPTGPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYISPLGGGPGLPPMMPPGPPAPNTNPFLL
uniprot
proteins
function
FUNCTION: Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis (By similarity). {ECO:0000250|UniProtKB:O88339, ECO:0000250|UniProtKB:Q9Y6I3}.
uniprot
proteins
mass_dalton
60212
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine and/or threonine residues in mitotic cells. Phosphorylation reduces interaction with REPS2, AP-2 and the membrane fraction. Depolarization of synaptosomes results in dephosphorylation. {ECO:0000269|PubMed:9920862}.; PTM: Ubiquitinated. {ECO:0000250}.
uniprot
proteins
protein_family
Epsin family
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
9813051
uniprot
proteins
pubmed
9920862
uniprot
proteins
sequence_length
575
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Membrane, clathrin-coated pit {ECO:0000250}. Note=Associated with the cytoplasmic membrane at sites where clathrin-coated pits are forming. Colocalizes with clathrin and AP-2 in a punctate pattern on the plasma membrane. Detected in presynaptic nerve terminals and in Golgi stacks. May shuttle to the nucleus when associated with ZBTB16/ZNF145 (By similarity). {ECO:0000250}.
uniprot
proteins