Glrx3
entrez
30926
canonical
uniprot
Q9CQM9
canonical
ensembl
ENSMUSG00000031068
resolver
ensp
ENSMUSP00000066621
resolver
enst
ENSMUST00000064404
resolver
genesymbol
Glrx3
resolver
genesymbol_syn
Picot
resolver
genesymbol_syn
Txnl2
resolver
uniprot
Q5I0V8
resolver
uniprot
Q9JLZ2
resolver
uniprot_entry
GLRX3_MOUSE
resolver
uniprot_sec
Q5I0V8
resolver
uniprot_sec
Q9JLZ2
resolver
amino_acid_sequence
MAAGAAEAGEAAVAVVEVGSAQQFEELLRLKTKSLLVVHFWAPWAPQCVQMNDVMAELAKEHPHVSFVKLEAEAVPEVSEKYEISSVPTFLFFKNSQKVDRLDGAHAPELTKKVQRHVSSGAFPPSTNEHLKEDLSLRLKKLTHAAPCMLFMKGTPQEPRCGFSKQMVEILHKHNIQFSSFDIFSDEEVRQGLKTYSNWPTYPQLYVSGELIGGLDIIKELEASEELDTICPKAPKLEERLKVLTNKASVMLFMKGNKQEAKCGFSKQILEILNSTGVEYETFDILEDEEVRQGLKTFSNWPTYPQLYVRGDLVGGLDIVKELKDNGELLPILKGEN
uniprot
proteins
function
FUNCTION: Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins (By similarity). Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (PubMed:16809552, PubMed:18258855, PubMed:18929570). Required for hemoglobin maturation. Does not possess any thioredoxin activity since it lacks the conserved motif that is essential for catalytic activity (By similarity). {ECO:0000250|UniProtKB:O76003, ECO:0000269|PubMed:16809552, ECO:0000269|PubMed:18258855, ECO:0000269|PubMed:18929570}.
uniprot
proteins
mass_dalton
37778
uniprot
proteins
pubmed
10636891
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16809552
uniprot
proteins
pubmed
18258855
uniprot
proteins
pubmed
18929570
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
337
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O76003}. Cytoplasm, cell cortex {ECO:0000269|PubMed:18258855}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:18258855}. Note=Under the plasma membrane (PubMed:18258855). After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area (PubMed:18258855). In the Z line, found associated with CSRP3 (PubMed:18258855). {ECO:0000269|PubMed:18258855}.
uniprot
proteins