Casp9
entrez
12371
canonical
uniprot
Q8C3Q9
canonical
ensembl
ENSMUSG00000028914
resolver
ensp
ENSMUSP00000030747
resolver
ensp
ENSMUSP00000095414
resolver
enst
ENSMUST00000030747
resolver
enst
ENSMUST00000097805
resolver
genesymbol
Casp9
resolver
genesymbol_syn
Mch6
resolver
uniprot
A2AS93
resolver
uniprot_entry
A2AS93_MOUSE
resolver
uniprot_entry
CASP9_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by BIRC6; following inhibition of BIRC6-caspase binding by DIABLO/SMAC, BIRC6 is subjected to caspase cleavage, leading to an increase in active caspases. {ECO:0000250|UniProtKB:P55211}.
uniprot
proteins
amino_acid_sequence
MDEADRQLLRRCRVRLVSELQVAELWDALLSRELFTRDMIEDIQQAGSGSRRDQARQLVTDLETRGRQALPLFISCLEDTGQGTLASLLQSGRQAAKQDPEAVKPLDHLVPVVLGPMGLTAKEQRVVKLDPSQPAVGNLTPVVLGPEELWPARLKPEVLRPETPRPVDIGSGGAHDVCVPGKIRGHADMAYTLDSDPCGHCLIINNVNFCPSSGLGTRTGSNLDRDKLEHRFRWLRFMVEVKNDLTAKKMVTALMEMAHRNHRALDCFVVVILSHGCQASHLQFPGAVYGTDGCSVSIEKIVNIFNGSGCPSLGGKPKLFFIQACGGEQKDHGFEVACTSSQGRTLDSDSEPDAVPYQEGPRPLDQLDAVSSLPTPSDILVSYSTFPGFVSWRDKKSGSWYIETLDGILEQWARSEDLQSLLLRVANAVSAKGTYKQIPGCFNFLRKKLFFKTS
uniprot
proteins
ec_number
3.4.22.62
uniprot
proteins
function
FUNCTION: Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates effector caspases caspase-3 (CASP3) or caspase-7 (CASP7). Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Cleaves BIRC6 following inhibition of BIRC6-caspase binding by DIABLO/SMAC (By similarity). {ECO:0000250|UniProtKB:P55211}.
uniprot
proteins
mass_dalton
49979
uniprot
proteins
post_translational_modification
PTM: Cleavages at Asp-353 by granzyme B and at Asp-368 by caspase-3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events (By similarity). {ECO:0000250|UniProtKB:P55211}.; PTM: Phosphorylated at Thr-163 by MAPK1/ERK2. Phosphorylation at Thr-163 is sufficient to block caspase-9 processing and subsequent caspase-3 activation (By similarity). Phosphorylation on Tyr-191 by ABL1/c-Abl; occurs in the response of cells to DNA damage (PubMed:15657060). {ECO:0000250|UniProtKB:P55211, ECO:0000269|PubMed:15657060}.; PTM: Ubiquitinated by BIRC6; this activity is inhibited by DIABLO/SMAC. {ECO:0000250|UniProtKB:P55211}.
uniprot
proteins
protein_family
Peptidase C14A family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15657060
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
454
uniprot
proteins