Kitlg
entrez
60427
canonical
uniprot
P21581
canonical
ensembl
ENSRNOG00000005386
resolver
ensp
ENSRNOP00000008471
resolver
ensp
ENSRNOP00000109747
resolver
genesymbol
Kitlg
resolver
genesymbol_syn
Kitl
resolver
genesymbol_syn
Mgf
resolver
genesymbol_syn
scf
resolver
uniprot
A0A0A0MXU5
resolver
uniprot
Q54A14
resolver
uniprot
Q9QWZ4
resolver
uniprot
Q9Z2E7
resolver
uniprot_entry
Q54A14_RAT
resolver
uniprot_entry
SCF_RAT
resolver
uniprot_sec
A0A0A0MXU5
resolver
uniprot_sec
Q9QWZ4
resolver
uniprot_sec
Q9Z2E7
resolver
amino_acid_sequence
MKKTQTWIITCIYLQLLLFNPLVKTQEICRNPVTDNVKDITKLVANLPNDYMITLNYVAGMDVLPSHCWLRDMVTHLSVSLTTLLDKFSNISEGLSNYSIIDKLGKIVDDLVACMEENAPKNVKESLKKPETRNFTPEEFFSIFNRSIDAFKDFMVASDTSDCVLSSTLGPEKDSRVSVTKPFMLPPVAASSLRNDSSSSNRKAAKSPEDPGLQWTAMALPALISLVIGFAFGALYWKKKQSSLTRAVENIQINEEDNEISMLQQKEREFQEV
uniprot
proteins
function
FUNCTION: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
uniprot
proteins
mass_dalton
30712
uniprot
proteins
post_translational_modification
PTM: A soluble form is produced by proteolytic processing of isoform 1 in the extracellular domain.; PTM: The identity of N- and O-linked saccharides is not reported in PubMed:1708771. The O-linked polysaccharides are probably the mucin type linked to GalNAc. {ECO:0000269|PubMed:1708771}.
uniprot
proteins
protein_family
SCF family
uniprot
proteins
pubmed
1708771
uniprot
proteins
pubmed
2208278
uniprot
proteins
pubmed
2208279
uniprot
proteins
sequence_length
273
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000250|UniProtKB:P21583}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250|UniProtKB:P21583}; Single-pass type I membrane protein {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P21583}. Cell projection, filopodium {ECO:0000250|UniProtKB:P21583}.; SUBCELLULAR LOCATION: [Soluble KIT ligand]: Secreted {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 215..237; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins