SLC12A2
entrez
6558
canonical
uniprot
P55011
canonical
ensembl
ENSG00000064651
resolver
ensp
ENSP00000262461
resolver
ensp
ENSP00000340878
resolver
ensp
ENSP00000486323
resolver
genesymbol
SLC12A2
resolver
genesymbol_syn
NKCC1
resolver
hgnc
HGNC:10911
resolver
uniprot
B7ZM24
resolver
uniprot
Q53ZR1
resolver
uniprot
Q8N713
resolver
uniprot
Q8WWH7
resolver
uniprot_entry
B7ZM24_HUMAN
resolver
uniprot_entry
Q53ZR1_HUMAN
resolver
uniprot_entry
S12A2_HUMAN
resolver
uniprot_sec
Q8N713
resolver
uniprot_sec
Q8WWH7
resolver
activity_regulation
ACTIVITY REGULATION: Activated following phosphorylation by OXSR1/OSR1 and STK39/SPAK downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4) (PubMed:16669787, PubMed:16832045, PubMed:21613606). Inhibited by bumetanide (PubMed:32081947, PubMed:35585053, PubMed:36239040, PubMed:36306358, PubMed:7629105). Inhibited by furosemide (PubMed:36306358). {ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:16832045, ECO:0000269|PubMed:21613606, ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0000269|PubMed:7629105}.
uniprot
proteins
amino_acid_sequence
MEPRPTAPSSGAPGLAGVGETPSAAALAAARVELPGTAVPSVPEDAAPASRDGGGVRDEGPAAAGDGLGRPLGPTPSQSRFQVDLVSENAGRAAAAAAAAAAAAAAAGAGAGAKQTPADGEASGESEPAKGSEEAKGRFRVNFVDPAASSSAEDSLSDAAGVGVDGPNVSFQNGGDTVLSEGSSLHSGGGGGSGHHQHYYYDTHTNTYYLRTFGHNTMDAVPRIDHYRHTAAQLGEKLLRPSLAELHDELEKEPFEDGFANGEESTPTRDAVVTYTAESKGVVKFGWIKGVLVRCMLNIWGVMLFIRLSWIVGQAGIGLSVLVIMMATVVTTITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGAIGLIFAFANAVAVAMYVVGFAETVVELLKEHSILMIDEINDIRIIGAITVVILLGISVAGMEWEAKAQIVLLVILLLAIGDFVIGTFIPLESKKPKGFFGYKSEIFNENFGPDFREEETFFSVFAIFFPAATGILAGANISGDLADPQSAIPKGTLLAILITTLVYVGIAVSVGSCVVRDATGNVNDTIVTELTNCTSAACKLNFDFSSCESSPCSYGLMNNFQVMSMVSGFTPLISAGIFSATLSSALASLVSAPKIFQALCKDNIYPAFQMFAKGYGKNNEPLRGYILTFLIALGFILIAELNVIAPIISNFFLASYALINFSVFHASLAKSPGWRPAFKYYNMWISLLGAILCCIVMFVINWWAALLTYVIVLGLYIYVTYKKPDVNWGSSTQALTYLNALQHSIRLSGVEDHVKNFRPQCLVMTGAPNSRPALLHLVHDFTKNVGLMICGHVHMGPRRQAMKEMSIDQAKYQRWLIKNKMKAFYAPVHADDLREGAQYLMQAAGLGRMKPNTLVLGFKKDWLQADMRDVDMYINLFHDAFDIQYGVVVIRLKEGLDISHLQGQEELLSSQEKSPGTKDVVVSVEYSKKSDLDTSKPLSEKPITHKVEEEDGKTATQPLLKKESKGPIVPLNVADQKLLEASTQFQKKQGKNTIDVWWLFDDGGLTLLIPYLLTTKKKWKDCKIRVFIGGKINRIDHDRRAMATLLSKFRIDFSDIMVLGDINTKPKKENIIAFEEIIEPYRLHEDDKEQDIADKMKEDEPWRITDNELELYKTKTYRQIRLNELLKEHSSTANIIVMSLPVARKGAVSSALYMAWLEALSKDLPPILLVRGNHQSVLTFYS
uniprot
proteins
disease_involvement
DISEASE: Deafness, autosomal dominant, 78 (DFNA78) [MIM:619081]: A form of non-syndromic deafness characterized by congenital, profound bilateral sensorineural hearing loss affecting all frequencies. Some patients may have mild motor delay early in life due to vestibular dysfunction. Sensorineural hearing loss results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269|PubMed:32294086, ECO:0000269|PubMed:32658972}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Delpire-McNeill syndrome (DELMNES) [MIM:619083]: An autosomal dominant neurodevelopmental disorder characterized by global developmental delay, hypotonia with delayed or absent walking, bilateral sensorineural deafness, poor or absent speech, and mild to severe intellectual disability. Additional variable features may include spasticity or minor involvement of other organ systems, such as hip dislocation or ventricular septal defect. {ECO:0000269|PubMed:32658972}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Kilquist syndrome (KILQS) [MIM:619080]: An autosomal recessive, multisystem disorder characterized by severe global developmental delay, sensorineural hearing loss, poor overall growth, mild facial dysmorphism, gastrointestinal anomalies such as gastroesophageal reflux or midgut malrotation, and a striking lack of tear fluid, saliva, and sweat. {ECO:0000269|PubMed:30740830, ECO:0000269|PubMed:32754646}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:33597714, PubMed:35585053, PubMed:36239040, PubMed:36306358, PubMed:7629105). Plays a vital role in the regulation of ionic balance and cell volume (PubMed:16669787, PubMed:32081947, PubMed:32294086, PubMed:7629105). {ECO:0000269|PubMed:16669787, ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:32294086, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0000269|PubMed:7629105}.
uniprot
proteins
mass_dalton
131447
uniprot
proteins
mutagenesis
MUTAGEN 217; /note="T->A,S,E: Impairs transporter activity."; /evidence="ECO:0000269|PubMed:35585053"; MUTAGEN 219; /note="D->A: Impairs transporter activity."; /evidence="ECO:0000269|PubMed:35585053"; MUTAGEN 235; /note="G->A: Impairs transporter activity."; /evidence="ECO:0000269|PubMed:35585053"; MUTAGEN 236..249; /note="EKLLRPSLAELHDE->PKVNRPALLEIHEQ: Decrease in Cl(-) influx and impairs transporter activity."; /evidence="ECO:0000269|PubMed:35585053"; MUTAGEN 236..249; /note="EKLLRPSLAELHDE->PKVNRPSLLEIHEQ: Decrease in Cl(-) influx when mutated to the equivalent sequence in NKCC2."; /evidence="ECO:0000269|PubMed:35585053"; MUTAGEN 237; /note="K->A: Impairs transporter activity."; /evidence="ECO:0000269|PubMed:35585053"; MUTAGEN 238; /note="L->A: Impairs transporter activity."; /evidence="ECO:0000269|PubMed:35585053"; MUTAGEN 240; /note="R->A: Impairs transporter activity."; /evidence="ECO:0000269|PubMed:35585053"; MUTAGEN 241; /note="P->A: Impairs transporter activity."; /evidence="ECO:0000269|PubMed:35585053"; MUTAGEN 242; /note="S->A,E: Impairs transporter activity."; /evidence="ECO:0000269|PubMed:35585053"; MUTAGEN 243; /note="L->A: Abolishes transporter activity."; /evidence="ECO:0000269|PubMed:35585053"; MUTAGEN 244; /note="A->E: Impairs transporter activity."; /evidence="ECO:0000269|PubMed:35585053"; MUTAGEN 246; /note="L->S: Impairs transporter activity."; /evidence="ECO:0000269|PubMed:35585053"; MUTAGEN 247; /note="H->A: Impairs transporter activity."; /evidence="ECO:0000269|PubMed:35585053"; MUTAGEN 248; /note="D->A: Impairs transporter activity."; /evidence="ECO:0000269|PubMed:35585053"; MUTAGEN 250; /note="L->S: Impairs transporter activity."; /evidence="ECO:0000269|PubMed:35585053"; MUTAGEN 252; /note="K->A: Impairs transporter activity."; /evidence="ECO:0000269|PubMed:35585053"; MUTAGEN 289; /note="K->N: Impairs transporter activity. Impairs transporter activity and reduced sensitivity to NKCC inhibitor bumetanide; when associated with E-492 and C-671."; /evidence="ECO:0000269|PubMed:35585053"; MUTAGEN 294; /note="R->A: Severely impairs transporter activity."; /evidence="ECO:0000269|PubMed:32081947"; MUTAGEN 301; /note="G->C: Impairs transporter activity."; /evidence="ECO:0000269|PubMed:35585053"; MUTAGEN 307; /note="R->E: Abolished cation-chloride cotransporter activity."; /evidence="ECO:0000269|PubMed:33597714"; MUTAGEN 358; /note="R->K: Strongly reduced cation-chloride cotransporter activity."; /evidence="ECO:0000269|PubMed:33597714"; MUTAGEN 383; /note="Y->F,S: Impairs transporter activity."; /evidence="ECO:0000269|PubMed:36239040"; MUTAGEN 389; /note="E->Q,R: Strongly reduced cation-chloride cotransporter activity."; /evidence="ECO:0000269|PubMed:33597714"; MUTAGEN 429; /note="E->A: Impairs transporter activity."; /evidence="ECO:0000269|PubMed:36239040"; MUTAGEN 431; /note="E->A,Q: Impairs transporter activity."; /evidence="ECO:0000269|PubMed:36239040"; MUTAGEN 486; /note="T->C: Strongly reduced cation-chloride cotransporter activity."; /evidence="ECO:0000269|PubMed:33597714"; MUTAGEN 487; /note="F->A: Impairs transporter activity."; /evidence="ECO:0000269|PubMed:36239040"; MUTAGEN 487; /note="F->C: Does not affect cation-chloride cotransporter activity."; /evidence="ECO:0000269|PubMed:33597714"; MUTAGEN 488; /note="F->C: Slighly reduced cation-chloride cotransporter activity."; /evidence="ECO:0000269|PubMed:33597714"; MUTAGEN 489; /note="S->C: Slighly reduced cation-chloride cotransporter activity."; /evidence="ECO:0000269|PubMed:33597714"; MUTAGEN 490; /note="V->C: Strongly reduced cation-chloride cotransporter activity."; /evidence="ECO:0000269|PubMed:33597714"; MUTAGEN 491; /note="F->C: Reduced cation-chloride cotransporter activity."; /evidence="ECO:0000269|PubMed:33597714"; MUTAGEN 492; /note="A->C: Reduced cation-chloride cotransporter activity."; /evidence="ECO:0000269|PubMed:33597714"; MUTAGEN 492; /note="A->E: Active at elevated intracellular chloride concentrations that are inhibitory to wild-type. Impairs transporter activity. Impairs transporter activity and reduced sensitivity to NKCC inhibitor bumetanide; when associated with N-289 and C-671."; /evidence="ECO:0000269|PubMed:35585053"; MUTAGEN 493; /note="I->C: Reduced cation-chloride cotransporter activity."; /evidence="ECO:0000269|PubMed:33597714"; MUTAGEN 494; /note="F->C: Reduced cation-chloride cotransporter activity."; /evidence="ECO:0000269|PubMed:33597714"; MUTAGEN 495; /note="F->C: Reduced cation-chloride cotransporter activity."; /evidence="ECO:0000269|PubMed:33597714"; MUTAGEN 497; /note="A->C: Strongly reduced cation-chloride cotransporter activity."; /evidence="ECO:0000269|PubMed:33597714"; MUTAGEN 498; /note="A->C: Strongly reduced cation-chloride cotransporter activity."; /evidence="ECO:0000269|PubMed:33597714"; MUTAGEN 499; /note="T->C: Strongly reduced cation-chloride cotransporter activity."; /evidence="ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053"; MUTAGEN 500; /note="G->C: Strongly reduced cation-chloride cotransporter activity."; /evidence="ECO:0000269|PubMed:33597714"; MUTAGEN 501; /note="I->C: Strongly reduced cation-chloride cotransporter activity."; /evidence="ECO:0000269|PubMed:33597714"; MUTAGEN 502; /note="L->C: Strongly reduced cation-chloride cotransporter activity."; /evidence="ECO:0000269|PubMed:33597714"; MUTAGEN 503; /note="A->C: Reduced cation-chloride cotransporter activity."; /evidence="ECO:0000269|PubMed:33597714"; MUTAGEN 504; /note="G->C: Strongly reduced cation-chloride cotransporter activity."; /evidence="ECO:0000269|PubMed:33597714"; MUTAGEN 505; /note="A->C: Strongly reduced cation-chloride cotransporter activity."; /evidence="ECO:0000269|PubMed:33597714"; MUTAGEN 506; /note="N->C: Strongly reduced cation-chloride cotransporter activity."; /evidence="ECO:0000269|PubMed:33597714"; MUTAGEN 507; /note="I->C: Strongly reduced cation-chloride cotransporter activity."; /evidence="ECO:0000269|PubMed:33597714"; MUTAGEN 510; /note="D->A,C,Q,K: Strongly reduced cation-chloride cotransporter activity."; /evidence="ECO:0000269|PubMed:33597714"; MUTAGEN 510; /note="D->N: Does not affect cation-chloride cotransporter activity."; /evidence="ECO:0000269|PubMed:33597714"; MUTAGEN 533; /note="Y->F,E: Impairs transporter activity."; /evidence="ECO:0000269|PubMed:36239040"; MUTAGEN 613; /note="S->C,A,D,T: Abolished cation-chloride cotransporter activity."; /evidence="ECO:0000269|PubMed:33597714"; MUTAGEN 614; /note="S->C,A,D,T: Abolished cation-chloride cotransporter activity."; /evidence="ECO:0000269|PubMed:33597714"; MUTAGEN 624; /note="K->A,C,D: Nearly abolished cation-chloride cotransporter activity."; /evidence="ECO:0000269|PubMed:33597714"; MUTAGEN 632; /note="D->A,E: Strongly reduced cation-chloride cotransporter activity."; /evidence="ECO:0000269|PubMed:33597714"; MUTAGEN 670; /note="E->A,C: Slightly reduced cation-chloride cotransporter activity."; /evidence="ECO:0000269|PubMed:33597714"; MUTAGEN 671; /note="L->A,C: Reduced cation-chloride cotransporter activity."; /evidence="ECO:0000269|PubMed:33597714"; MUTAGEN 671; /note="L->C: Active at elevated intracellular chloride concentrations that are inhibitory to wild-type. Impairs transporter activity. Impairs transporter activity and reduced sensitivity to NKCC inhibitor bumetanide; when associated with N-289 and E-492."; /evidence="ECO:0000269|PubMed:35585053"; MUTAGEN 682; /note="F->C: Impairs transporter activity."; /evidence="ECO:0000269|PubMed:35585053"; MUTAGEN 686; /note="Y->S,E: Impairs transporter activity."; /evidence="ECO:0000269|PubMed:36239040"; MUTAGEN 1031; /note="D->A: Impairs transporter activity."; /evidence="ECO:0000269|PubMed:35585053"; MUTAGEN 1174; /note="R->A: Impairs transporter activity."; /evidence="ECO:0000269|PubMed:35585053"; MUTAGEN 1201; /note="R->A: Impairs transporter activity."; /evidence="ECO:0000269|PubMed:35585053
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Thr-203, Thr-207 and Thr-212 by OXSR1/OSR1 and STK39/SPAK downstream of WNK kinases (WNK1, WNK2, WNK3 or WNK4), promoting its activity. {ECO:0000269|PubMed:16669787}.
uniprot
proteins
protein_family
SLC12A transporter family
uniprot
proteins
pubmed
11700976
uniprot
proteins
pubmed
12145305
uniprot
proteins
pubmed
16669787
uniprot
proteins
pubmed
16832045
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21613606
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
30740830
uniprot
proteins
pubmed
32081947
uniprot
proteins
pubmed
32294086
uniprot
proteins
pubmed
32658972
uniprot
proteins
pubmed
32754646
uniprot
proteins
pubmed
33597714
uniprot
proteins
pubmed
35585053
uniprot
proteins
pubmed
36239040
uniprot
proteins
pubmed
36306358
uniprot
proteins
pubmed
7629105
uniprot
proteins
sequence_length
1212
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000305|PubMed:32081947, ECO:0000305|PubMed:7629105}; Multi-pass membrane protein {ECO:0000305|PubMed:32081947, ECO:0000305|PubMed:33597714}.
uniprot
proteins
transmembrane_region
TRANSMEM 287..316; /note="Discontinuously helical; Name=1"; /evidence="ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:6PZT, ECO:0007744|PDB:7D10, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7N3N, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7S1Y, ECO:0007744|PDB:7S1Z, ECO:0007744|PDB:7SFL, ECO:0007744|PDB:7SMP, ECO:0007744|PDB:7ZGO, ECO:0007744|PDB:8STE"; TRANSMEM 317..336; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:6PZT, ECO:0007744|PDB:7D10, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7N3N, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7S1Y, ECO:0007744|PDB:7S1Z, ECO:0007744|PDB:7SFL, ECO:0007744|PDB:7SMP, ECO:0007744|PDB:7ZGO, ECO:0007744|PDB:8STE"; TRANSMEM 368..395; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:6PZT, ECO:0007744|PDB:7D10, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7N3N, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7S1Y, ECO:0007744|PDB:7S1Z, ECO:0007744|PDB:7SFL, ECO:0007744|PDB:7SMP, ECO:0007744|PDB:7ZGO, ECO:0007744|PDB:8STE"; TRANSMEM 406..429; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:6PZT, ECO:0007744|PDB:7D10, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7N3N, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7S1Y, ECO:0007744|PDB:7S1Z, ECO:0007744|PDB:7SFL, ECO:0007744|PDB:7SMP, ECO:0007744|PDB:7ZGO, ECO:0007744|PDB:8STE"; TRANSMEM 433..454; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:6PZT, ECO:0007744|PDB:7D10, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7N3N, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7S1Y, ECO:0007744|PDB:7S1Z, ECO:0007744|PDB:7SFL, ECO:0007744|PDB:7SMP, ECO:0007744|PDB:7ZGO, ECO:0007744|PDB:8STE"; TRANSMEM 487..504; /note="Discontinuously helical; Name=6"; /evidence="ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:6PZT, ECO:0007744|PDB:7D10, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7N3N, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7S1Y, ECO:0007744|PDB:7S1Z, ECO:0007744|PDB:7SFL, ECO:0007744|PDB:7SMP, ECO:0007744|PDB:7ZGO, ECO:0007744|PDB:8STE"; TRANSMEM 520..541; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:6PZT, ECO:0007744|PDB:7D10, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7N3N, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7S1Y, ECO:0007744|PDB:7S1Z, ECO:0007744|PDB:7SFL, ECO:0007744|PDB:7SMP, ECO:0007744|PDB:7ZGO, ECO:0007744|PDB:8STE"; TRANSMEM 599..623; /note="Helical; Name=8"; /evidence="ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:6PZT, ECO:0007744|PDB:7D10, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7N3N, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7S1Y, ECO:0007744|PDB:7S1Z, ECO:0007744|PDB:7SFL, ECO:0007744|PDB:7SMP, ECO:0007744|PDB:7ZGO, ECO:0007744|PDB:8STE"; TRANSMEM 652..672; /note="Helical; Name=9"; /evidence="ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:6PZT, ECO:0007744|PDB:7D10, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7N3N, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7S1Y, ECO:0007744|PDB:7S1Z, ECO:0007744|PDB:7SFL, ECO:0007744|PDB:7SMP, ECO:0007744|PDB:7ZGO, ECO:0007744|PDB:8STE"; TRANSMEM 673..691; /note="Helical; Name=10"; /evidence="ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:6PZT, ECO:0007744|PDB:7D10, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7N3N, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7S1Y, ECO:0007744|PDB:7S1Z, ECO:0007744|PDB:7SFL, ECO:0007744|PDB:7SMP, ECO:0007744|PDB:7ZGO, ECO:0007744|PDB:8STE"; TRANSMEM 715..732; /note="Helical; Name=11"; /evidence="ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:6PZT, ECO:0007744|PDB:7D10, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7N3N, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7S1Y, ECO:0007744|PDB:7S1Z, ECO:0007744|PDB:7SFL, ECO:0007744|PDB:7SMP, ECO:0007744|PDB:7ZGO, ECO:0007744|PDB:8STE"; TRANSMEM 733..745; /note="Helical; Name=12"; /evidence="ECO:0000269|PubMed:32081947, ECO:0000269|PubMed:33597714, ECO:0000269|PubMed:35585053, ECO:0000269|PubMed:36239040, ECO:0000269|PubMed:36306358, ECO:0007744|PDB:6PZT, ECO:0007744|PDB:7D10, ECO:0007744|PDB:7MXO, ECO:0007744|PDB:7N3N, ECO:0007744|PDB:7S1X, ECO:0007744|PDB:7S1Y, ECO:0007744|PDB:7S1Z, ECO:0007744|PDB:7SFL, ECO:0007744|PDB:7SMP, ECO:0007744|PDB:7ZGO, ECO:0007744|PDB:8STE
uniprot
proteins