Rnf212b
entrez
102632837
canonical
uniprot
D3Z423
canonical
ensembl
ENSMUSG00000112858
resolver
ensp
ENSMUSP00000151344
resolver
enst
ENSMUST00000218311
resolver
genesymbol
Rnf212b
resolver
genesymbol_syn
Gm10332
resolver
uniprot
D3Z2T6
resolver
uniprot_entry
R212B_MOUSE
resolver
uniprot_sec
D3Z2T6
resolver
amino_acid_sequence
MDWFHCNQCFRKDGAHFFVTSCGHIFCKKCMTLEKCAVCGNLCKHLALSDNLKPQEKKFFKSPVETALQCFSHISQVWCFQKKQTDLLIAFYKDRITKLEAAVKEAQEMAASQNKELSALRKENGELKKILDILKGSPSCYYGSRLTTPRPVGITSPSQSVAPRPSSHHSSQVVSRSSSMESIPYTVAGMGHVEQGSRGLHVRSTPGDSYTETPSPASTHSLSYRPSSASSGQGVSFRPFFSGDSGHTRVLTPNNSGRRESRTTPESLPGFQLPVLQTFYQQRQMGLARKDGWNISR
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Ubiquitin E3 ligase that acts as a crucial factor for crossing-over (CO) formation during meiosis. Essential for normal prophase I progression and for ensuring appropriate CO designation in meiosis. Recruits key components of the cross-over machinery either directly ou indirectly, leading to the activation of the MutL-gamma complex. The function of RNF212B in CO designation is dependent on its catalytic activity. {ECO:0000269|PubMed:38865271}.
uniprot
proteins
mass_dalton
32990
uniprot
proteins
mutagenesis
MUTAGEN 24; /note="H->A: Abolishes autoubiquitinylation. Spermatocytes recapitulated the phenotype observed in Rnf212b deficient mice, including modest synapsis defects, a reduction in the localization of pro-CO factors (MSH4, TEX11, SHOC1) and absence of late CO-intermediates."; /evidence="ECO:0000269|PubMed:38865271
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:38865271}.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. {ECO:0000269|PubMed:38865271}.
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
38865271
uniprot
proteins
sequence_length
297
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:38865271}. Note=Colocalizes with RNF212. {ECO:0000269|PubMed:38865271}.
uniprot
proteins