Samd8
entrez
67630
canonical
uniprot
Q9DA37
canonical
ensembl
ENSMUSG00000021770
resolver
ensp
ENSMUSP00000022292
resolver
ensp
ENSMUSP00000112803
resolver
enst
ENSMUST00000022292
resolver
enst
ENSMUST00000119430
resolver
genesymbol
Samd8
resolver
uniprot
F6UBF5
resolver
uniprot
Q14AQ4
resolver
uniprot
Q3UH82
resolver
uniprot
Q497L5
resolver
uniprot_entry
F6UBF5_MOUSE
resolver
uniprot_entry
Q14AQ4_MOUSE
resolver
uniprot_entry
Q3UH82_MOUSE
resolver
uniprot_entry
Q497L5_MOUSE
resolver
uniprot_entry
SAMD8_MOUSE
resolver
amino_acid_sequence
MPAGSRAGSRLRSGSLPRPSRLTLKALRPAYAPRTPDSNGDLDTGSELGPGSPAPTAEEVEKEMAGPSQLCIRRWTTKHVAVWLKDEGFFEYVDILCNKHRLDGITLLTLTEYDLRSPPLEIKVLGDIKRLMLSVRKLQKIHTDVLEEMGYNSDSPMSPMTPFLSALQSADWLCNGEPTHSCDGPIPDLSSDQYQYMNGKNKHSARRLDPEYWKTILSCVYVFIVFGFTSFIMVIVHERVPDMQTYPPLPDIFLDSVPRIPWAFSMTEVCGVILCYIWILVLLLHKHRSILLRRLCSLMGTVFLLRCFTMFVTSLSVPGQHLQCTGKIYGSVWEKLRRAFAIWSGFGMTLTGVHTCGDYMFSGHTVVLTMLNFFVTEYTPRSWNFLHTLSWVLNLFGIFFILAAHEHYSIDVFIAFYITTRLFLYYHTLANTRAYHQSRRARIWFPMFSFFECNVNGTVPNEYCWPFSKPAIMKRLIG
uniprot
proteins
ec_number
2.7.8.-
uniprot
proteins
ec_number
3.1.4.62
uniprot
proteins
function
FUNCTION: Has phospholipase C (PLC) activity (PubMed:40998032). Shows specificity for phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE), hydrolyzing PE to produce phosphoethanolamine and diacylglycerol (1,2-diacyl-sn-glycerol, DAG) (PubMed:40998032). This reaction might act as a regulatory switch to activate serine palmitoyltransferase (SPT) and promote sphingolipid metabolism (PubMed:40998032). Can also function as a ceramide phosphoethanolamine (N-acylsphingoid 1-phosphoethanolamine, CPE) synthase when intracellular ceramide levels are elevated (PubMed:25605874). Binds the headgroup from PE, which is smaller and more hydrophilic than the phosphocholine headgroup transferred in the canonical sphingomyelin synthesis (SMS) reaction by SMS1 or SMS2, and transfers it on to the primary hydroxyl of a ceramide in the lumen of the endoplasmic reticulum. Plays a role as a ceramide sensor, helping to regulate ceramide homeostasis in the endoplasmic reticulum, which is critical for maintaining the integrity of the early secretory pathway (By similarity). {ECO:0000250|UniProtKB:Q96LT4, ECO:0000269|PubMed:25605874, ECO:0000269|PubMed:40998032}.
uniprot
proteins
mass_dalton
54713
uniprot
proteins
pathway_participation
PATHWAY: Sphingolipid metabolism. {ECO:0000305|PubMed:25605874}.; PATHWAY: Phospholipid metabolism. {ECO:0000305|PubMed:40998032}.
uniprot
proteins
protein_family
Sphingomyelin synthase family
uniprot
proteins
pubmed
14685263
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
25605874
uniprot
proteins
pubmed
40998032
uniprot
proteins
sequence_length
478
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 216..236; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 264..284; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 295..315; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 341..361; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 385..405; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 410..430; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins