Cd226
entrez
225825
canonical
uniprot
Q8K4F0
canonical
ensembl
ENSMUSG00000034028
resolver
ensp
ENSMUSP00000043551
resolver
ensp
ENSMUSP00000095104
resolver
ensp
ENSMUSP00000158239
resolver
ensp
ENSMUSP00000158324
resolver
ensp
ENSMUSP00000352919
resolver
enst
ENSMUST00000037142
resolver
enst
ENSMUST00000097496
resolver
enst
ENSMUST00000236452
resolver
enst
ENSMUST00000236828
resolver
genesymbol
Cd226
resolver
genesymbol_syn
Pta1
resolver
genesymbol_syn
dnam-1
resolver
uniprot
A0A494BAV0
resolver
uniprot
F6XEN1
resolver
uniprot
Q5DW69
resolver
uniprot
Q8K4E2
resolver
uniprot
Q8K4E3
resolver
uniprot_entry
A0A494BAV0_MOUSE
resolver
uniprot_entry
CD226_MOUSE
resolver
uniprot_entry
F6XEN1_MOUSE
resolver
uniprot_entry
Q5DW69_MOUSE
resolver
uniprot_entry
Q8K4E2_MOUSE
resolver
uniprot_entry
Q8K4E3_MOUSE
resolver
amino_acid_sequence
MAYVTWLLAILHVHKALCEETLWDTTVRLSETMTLECVYPLTHNLTQVEWTKNTGTKTVSIAVYNPNHNMHIESNYLHRVHFLNSTVGFRNMSLSFYNASEADIGIYSCLFHAFPNGPWEKKIKVVWSDSFEIAAPSDSYLSAEPGQDVTLTCQLPRTWPVQQVIWEKVQPHQVDILASCNLSQETRYTSKYLRQTRSNCSQGSMKSILIIPNAMAADSGLYRCRSEAITGKNKSFVIRLIITDGGTNKHFILPIVGGLVSLLLVILIIIIFILYNRKRRRQVRIPLKEPRDKQSKVATNCRSPTSPIQSTDDEKEDIYVNYPTFSRRPKPRL
uniprot
proteins
function
FUNCTION: Cell surface receptor that plays an important role in the immune system, particularly in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-cells and NK cells (PubMed:19029379, PubMed:24658051, PubMed:26552706). Functions as a costimulatory receptor upon recognition of target cells, such as virus-infected or tumor cells. Upon binding to its ligands PVR/CD155 or NECTIN2/CD112 on target cells, promotes the cytotoxic activity of NK cells and CTLs, enhancing their ability to kill these cells (PubMed:30591568). Mechanistically, phosphorylation by Src kinases such as LYN of FYN, enables binding to adapter GRB2, leading to activation of VAV1, PI3K and PLCG1. Promotes also activation of kinases ERK and AKT, as well as calcium fluxes (By similarity). {ECO:0000250|UniProtKB:Q15762, ECO:0000269|PubMed:19029379, ECO:0000269|PubMed:24658051, ECO:0000269|PubMed:26552706, ECO:0000269|PubMed:30591568}.
uniprot
proteins
mass_dalton
38063
uniprot
proteins
mutagenesis
MUTAGEN 319; /note="Y->F: Abrogates the ability to bind GRB2 and its capacity to signal and enhance cytotoxicity."; /evidence="ECO:0000269|PubMed:26552706
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation of Tyr-319 allows GRB2 binding and activation of subsequent signaling (PubMed:26552706). {ECO:0000269|PubMed:26552706}.
uniprot
proteins
pubmed
19029379
uniprot
proteins
pubmed
24658051
uniprot
proteins
pubmed
26552706
uniprot
proteins
pubmed
30591568
uniprot
proteins
sequence_length
333
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q15762}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q15762}. Note=Localizes to lipid rafts. {ECO:0000250|UniProtKB:Q15762}.
uniprot
proteins
transmembrane_region
TRANSMEM 255..275; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins