ATP6V0D1
entrez
9114
canonical
uniprot
P61421
canonical
ensembl
ENSG00000159720
resolver
ensp
ENSP00000290949
resolver
enst
ENST00000290949
resolver
genesymbol
ATP6V0D1
resolver
genesymbol_syn
ATP6D
resolver
genesymbol_syn
VPATPD
resolver
hgnc
HGNC:13724
resolver
uniprot
P12953
resolver
uniprot
Q02547
resolver
uniprot_entry
VA0D1_HUMAN
resolver
uniprot_sec
P12953
resolver
uniprot_sec
Q02547
resolver
amino_acid_sequence
MSFFPELYFNVDNGYLEGLVRGLKAGVLSQADYLNLVQCETLEDLKLHLQSTDYGNFLANEASPLTVSVIDDRLKEKMVVEFRHMRNHAYEPLASFLDFITYSYMIDNVILLITGTLHQRSIAELVPKCHPLGSFEQMEAVNIAQTPAELYNAILVDTPLAAFFQDCISEQDLDEMNIEIIRNTLYKAYLESFYKFCTLLGGTTADAMCPILEFEADRRAFIITINSFGTELSKEDRAKLFPHCGRLYPEGLAQLARADDYEQVKNVADYYPEYKLLFEGAGSNPGDKTLEDRFFEHEVKLNKLAFLNQFHFGVFYAFVKLKEQECRNIVWIAECIAQRHRAKIDNYIPIF
uniprot
proteins
function
FUNCTION: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:28296633, PubMed:30374053, PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (PubMed:30374053). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (PubMed:22053050). May play a role in coupling of proton transport and ATP hydrolysis (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). {ECO:0000250|UniProtKB:P51863, ECO:0000250|UniProtKB:Q6PGV1, ECO:0000269|PubMed:22053050, ECO:0000269|PubMed:28296633, ECO:0000269|PubMed:30374053, ECO:0000269|PubMed:33065002}.
uniprot
proteins
mass_dalton
40329
uniprot
proteins
protein_family
V-ATPase V0D/AC39 subunit family
uniprot
proteins
pubmed
11118322
uniprot
proteins
pubmed
12384298
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21844891
uniprot
proteins
pubmed
22053050
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28296633
uniprot
proteins
pubmed
29644770
uniprot
proteins
pubmed
30374053
uniprot
proteins
pubmed
33065002
uniprot
proteins
pubmed
8250920
uniprot
proteins
sequence_length
351
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:21844891}; Peripheral membrane protein {ECO:0000305|PubMed:21844891}; Cytoplasmic side {ECO:0000305|PubMed:21844891}. Lysosome membrane {ECO:0000305|PubMed:22053050, ECO:0000305|PubMed:30374053}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:P61420}; Peripheral membrane protein {ECO:0000305}. Note=Localizes to centrosome and the base of the cilium. {ECO:0000250|UniProtKB:Q6PGV1}.
uniprot
proteins