ADCY4
entrez
196883
canonical
uniprot
Q8NFM4
canonical
ensembl
ENSG00000129467
resolver
ensembl
ENSG00000284814
resolver
ensp
ENSP00000312126
resolver
ensp
ENSP00000393177
resolver
ensp
ENSP00000452250
resolver
genesymbol
ADCY4
resolver
hgnc
HGNC:235
resolver
uniprot
B3KV74
resolver
uniprot
D3DS75
resolver
uniprot
Q17R40
resolver
uniprot
Q6ZTM6
resolver
uniprot
Q86TZ7
resolver
uniprot
Q96ML7
resolver
uniprot_entry
ADCY4_HUMAN
resolver
uniprot_entry
Q86TZ7_HUMAN
resolver
uniprot_sec
B3KV74
resolver
uniprot_sec
D3DS75
resolver
uniprot_sec
Q17R40
resolver
uniprot_sec
Q6ZTM6
resolver
uniprot_sec
Q96ML7
resolver
activity_regulation
ACTIVITY REGULATION: Activated by forskolin. Insensitive to calcium/calmodulin. Stimulated by GNAS and by the G protein beta and gamma subunit complex. {ECO:0000250|UniProtKB:P26770}.
uniprot
proteins
amino_acid_sequence
MARLFSPRPPPSEDLFYETYYSLSQQYPLLLLLLGIVLCALAALLAVAWASGRELTSDPSFLTTVLCALGGFSLLLGLASREQRLQRWTRPLSGLVWVALLALGHAFLFTGGVVSAWDQVSYFLFVIFTAYAMLPLGMRDAAVAGLASSLSHLLVLGLYLGPQPDSRPALLPQLAANAVLFLCGNVAGVYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLRAATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLALLAGAYAVEDAGMEHRDPYLRELGEPTYLVIDPRAEEEDEKGTAGGLLSSLEGLKMRPSLLMTRYLESWGAAKPFAHLSHGDSPVSTSTPLPEKTLASFSTQWSLDRSRTPRGLDDELDTGDAKFFQVIEQLNSQKQWKQSKDFNPLTLYFREKEMEKEYRLSAIPAFKYYEACTFLVFLSNFIIQMLVTNRPPALAITYSITFLLFLLILFVCFSEDLMRCVLKGPKMLHWLPALSGLVATRPGLRIALGTATILLVFAMAITSLFFFPTSSDCPFQAPNVSSMISNLSWELPGSLPLISVPYSMHCCTLGFLSCSLFLHMSFELKLLLLLLWLAASCSLFLHSHAWLSECLIVRLYLGPLDSRPGVLKEPKLMGAISFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHLGTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAWALQSLGYTCYSRGVIKVKGKGQLCTYFLNTDLTRTGPPSATLG
uniprot
proteins
ec_number
4.6.1.1
uniprot
proteins
function
FUNCTION: Catalyzes the formation of the signaling molecule cAMP in response to G protein signaling. {ECO:0000250|UniProtKB:P26770}.
uniprot
proteins
mass_dalton
119794
uniprot
proteins
protein_family
Adenylyl cyclase class-4/guanylyl cyclase family
uniprot
proteins
pubmed
11549699
uniprot
proteins
pubmed
12503609
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21228062
uniprot
proteins
sequence_length
1077
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21228062}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:11549699}.
uniprot
proteins
transmembrane_region
TRANSMEM 29..50; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 61..80; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 94..117; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 120..138; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 141..162; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 170..190; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 586..607; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 611..633; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 664..687; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 715..736; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 744..764; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 791..807; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins