Plce1
entrez
74055
canonical
uniprot
Q8K4S1
canonical
ensembl
ENSMUSG00000024998
resolver
ensp
ENSMUSP00000130604
resolver
ensp
ENSMUSP00000138360
resolver
enst
ENSMUST00000169713
resolver
enst
ENSMUST00000182481
resolver
genesymbol
Plce1
resolver
genesymbol_syn
Kiaa1516
resolver
genesymbol_syn
Plce
resolver
uniprot
B9EHS1
resolver
uniprot
E9Q5G0
resolver
uniprot
Q3TS68
resolver
uniprot
Q80TC4
resolver
uniprot
Q8BZF3
resolver
uniprot
Q9JKM2
resolver
uniprot_entry
PLCE1_MOUSE
resolver
uniprot_sec
B9EHS1
resolver
uniprot_sec
E9Q5G0
resolver
uniprot_sec
Q3TS68
resolver
uniprot_sec
Q80TC4
resolver
uniprot_sec
Q8BZF3
resolver
uniprot_sec
Q9JKM2
resolver
activity_regulation
ACTIVITY REGULATION: Activated by the heterotrimeric G protein subunits GNA12, GNA13 and GNB1-GNG2. Activated by HRAS, RAP1A, RHOA, RHOB, RHOC, RRAS and RRAS2. Activated by the G(s)-coupled GPCRs ADRB2, PTGER1 and CHRM3 through cyclic-AMP formation and RAP2B activation. Inhibited by G(i)-coupled GPCRs (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MTSEEMAASVLIPVTQRKVASAQSVAEERSVKVSDAGIPRARAGRQGALIPPTISQWNKHKEESSRSDLSKVFSIARGELVCDENSNEEGWEENAPDSPENHAMNGNSLVQSHQHQFPRSQLCEARDSVTEDPCLQPGIPSPLERKVLPGIQLEMEDSPMDVSPAGSQPRIMESSGPHSDRNTAVFHFHYEADRTMSDAFHTLSENLILDDCANCVTLPGGQQNKNCMAYACKLVELTRTCGSKNGQVQCEHCTSLRDEYLCFESSCSKADEVCSGGGFCEDGFAHGPAAKTFLNPLEDFSDNCEDVDDFFKSKKERSTLLVRRFCKNDREVKKSVYTGTRAIMRTLPSGCIGPAAWNYVDQKKAGLLWPCGNVMGTLSAMDIRQSGSQRLSEAQWCLIYSAVRRGEEIEDTVGSLLHCSTQLPNSETAHGRIEDGPCLKQCVRDTECEFRATLQRTSIAQYITGSLLEATTSLGARSGLLSSFGGSTGRIMLKERQLGTSMANSNPVPSSSAGISKELIDLQPLIQFPEEVASILTEQEQNIYRRVLPMDYLCFLTRDLSSPECQRSLPRLKASISESILTSQSGEHNALEDLVMRFNEVSSWVTWLILTAGSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGLRSRKVLKMWQFMDQSDIETMRSLKDAMAQHESSVEYKKVVTRALHIPGCKVVPFCGVFLKELCEVLDGASGLLKLCPRYSSQEEALEFVADYSGQDNFLQRVGQNGLKNSEKELTVNSIFQVIRSCSRSLEMEEEDSASEGSGSRKNSLKDKARWQFIIGDLLDSENDIFEKSKECDPHGSEESQKAFDHGTELIPWYVLSIQADVHQFLLQGATVIHYDQDTHLSARCFLQLQPDNSTLTWMKPPTASPAGARPKLGVLSNMAEPGKFPSPGNAGVSGLAEGILDLFSVKAVYMGHPGIDIHTVCVQNKLSSMLLSETGVTLLYGLQTTDNRLLHFVAPKHTAEMLFSGLLELTTAVRKIRRFPDQRQQWLRKQYVSLYQEDGRYEGPTLAHAVELFGGRRWSTRNPSPGMSAKNAEKPNMQRNNTLGISTTKKKKKMLMRGESGEVTDDEMATRKAKMYRECRSRSGSDPQDVNEQEESEANVITNPPNPLHSRRAYSLTTAGSPNLATGMSSPISAWSSSSWHGRIRGGMQGFQSFMVSDSNMSFVEFVELFKSFSIRSRKDLKDIFDIYSVPCNRSASESAPLYTNLTIEENTSDLQPDLDLLTRNVSDLGLFIKSKQQLSDNQRQISDAIAAASIVTNGTGIESTSLGIFGVGILQLNDFLVNCQGEHCTYDEILSIIQKFEPSVSMCHQGLLSFEGFARFLMDKDNFASKNDESRENKKELQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSIELDCWDGDDGMPIIYHGHTLTTKIPFKEVVEAIDRSAFITSDLPIIISIENHCSLPQQRKMAEIFKSVFGEKLVAKFLFETDFSDDPMLPSPDQLRRKVLLKNKKLKAHQTPVDILKQKAHQLASMQAQAFTGGNANPPPASNEEEEDEEDEYDYDYESLSDDNILEDRPENKSCADKLQFEYNEEVPKRIKKADNSSGNKGKVYDMELGEEFYLPQNKKESRQIAPELSDLVIYCQAVKFPGLSTLNSSGSSRGKERKSRKSIFGNNPGRMSPGETAPFNRTSGKGSCEGMRHTWEESSPLSPSTSLSAIIRTPKCYHISSLNENAAKRLCRRGSQKLIQHTAYQLLRTYPAATRIDSSNPNPIMFWLHGIQLVALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKSCPMYQKFSPLERDLDNLDPAIYSLTIISGQNVCPSNSTGSPCIEVDVLGMPLDSCHFRTKPIHRNTLNPMWNEQFLFRVHFEDLVFLRFAVVENNSSAITAQRIIPLRALKRGYRHLQLRNLHNEILEISSLFINSRRMEENPSGSSMPASLMFNTEERKCSQTHKVTVHGVPGPEPFAVFTINEGTKAKQLLQQVLAVDQDTKCTATDYFLMEEKHFISKEKNECRKQPFQRAVGPEEDIVQILNSWFPEEGYVGRIVLKPQQETLEEKSIVFDDKEVILSSEEESFFVQVHDVSPEQPRTVIKAPRVSTAQDVIQQTLCKAKYSYSILNNPNPCDYVLLEEVLKDAANKKSSTPKSSQRILLDQECVFQAQSKWKGAGKFILKLKEQVQASREDKRRGISFASELKKLTKSTKQSRGLPSPPQLVASESVQSKEEKPVGALSSSDTVGYQQ
uniprot
proteins
ec_number
3.1.4.11
uniprot
proteins
function
FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downstream of AVIL to allow ARP2/3 complex assembly (By similarity). {ECO:0000250|UniProtKB:Q9P212, ECO:0000269|PubMed:12721365, ECO:0000269|PubMed:15604236, ECO:0000269|PubMed:15743817, ECO:0000269|PubMed:16293787}.
uniprot
proteins
mass_dalton
255047
uniprot
proteins
pubmed
11146508
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
12721365
uniprot
proteins
pubmed
12752375
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15604236
uniprot
proteins
pubmed
15743817
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16293787
uniprot
proteins
pubmed
17086182
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
2282
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9P212}. Cell membrane {ECO:0000250|UniProtKB:Q9P212}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9P212}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9P212}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9P212}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q9P212}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9P212}. Note=Recruited to plasma membrane by activated HRAS and RAP2. Recruited to perinuclear region by activated RAP1A. Isoform 1 and isoform 2 associates with Golgi membranes. {ECO:0000250|UniProtKB:Q9P212}.
uniprot
proteins