PC4
entrez
10923
canonical
uniprot
P53999
canonical
ensembl
ENSG00000113387
resolver
ensp
ENSP00000265073
resolver
ensp
ENSP00000422078
resolver
ensp
ENSP00000422806
resolver
ensp
ENSP00000426850
resolver
ensp
ENSP00000427100
resolver
ensp
ENSP00000549113
resolver
ensp
ENSP00000549115
resolver
ensp
ENSP00000549118
resolver
ensp
ENSP00000549119
resolver
ensp
ENSP00000549120
resolver
ensp
ENSP00000549121
resolver
ensp
ENSP00000592159
resolver
ensp
ENSP00000625017
resolver
ensp
ENSP00000625018
resolver
enst
ENST00000265073
resolver
enst
ENST00000502897
resolver
enst
ENST00000506237
resolver
enst
ENST00000512913
resolver
enst
ENST00000515355
resolver
enst
ENST00000879054
resolver
enst
ENST00000879056
resolver
enst
ENST00000879059
resolver
enst
ENST00000879060
resolver
enst
ENST00000879061
resolver
enst
ENST00000879062
resolver
enst
ENST00000922100
resolver
enst
ENST00000954958
resolver
enst
ENST00000954959
resolver
genesymbol
PC4
resolver
genesymbol
SUB1
resolver
genesymbol_syn
PC4
resolver
genesymbol_syn
RPO2TC1
resolver
genesymbol_syn
SUB1
resolver
hgnc
HGNC:19985
resolver
uniprot
Q6IBA2
resolver
uniprot
Q96L29
resolver
uniprot_entry
Q6IBA2_HUMAN
resolver
uniprot_entry
TCP4_HUMAN
resolver
uniprot_sec
Q96L29
resolver
amino_acid_sequence
MPKSKELVSSSSSGSDSDSEVDKKLKRKKQVAPEKPVKKQKTGETSRALSSSKQSSSSRDDNMFQIGKMRYVSVRDFKGKVLIDIREYWMDPEGEMKPGRKGISLNPEQWSQLKEQISDIDDAVRKL
uniprot
proteins
function
FUNCTION: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA). {ECO:0000269|PubMed:16605275, ECO:0000269|PubMed:16689930, ECO:0000269|PubMed:7628453, ECO:0000269|PubMed:8062391, ECO:0000269|PubMed:8062392, ECO:0000269|PubMed:9360603, ECO:0000269|PubMed:9482861}.
uniprot
proteins
mass_dalton
14395
uniprot
proteins
mutagenesis
MUTAGEN 68; /note="K->G: Reduced ssDNA binding."; /evidence="ECO:0000269|PubMed:16605275"; MUTAGEN 75; /note="R->G: Reduced ssDNA binding."; /evidence="ECO:0000269|PubMed:16605275"; MUTAGEN 77..80; /note="FKGK->AGG: Loss of ssDNA binding."; /evidence="ECO:0000269|PubMed:16605275"; MUTAGEN 86; /note="R->G: Loss of ssDNA binding."; /evidence="ECO:0000269|PubMed:16605275"; MUTAGEN 101; /note="K->G: Loss of ssDNA binding."; /evidence="ECO:0000269|PubMed:16605275
uniprot
proteins
post_translational_modification
PTM: Activity is controlled by protein kinases that target the regulatory region. Phosphorylation inactivates both ds DNA-binding and cofactor function, but does not affect binding to ssDNA. Seems to be phosphorylated in vivo by CK2 in at least 7 sites in the N-terminal Ser-rich region. {ECO:0000269|PubMed:16689930, ECO:0000269|PubMed:7809103, ECO:0000269|PubMed:9482861}.
uniprot
proteins
protein_family
Transcriptional coactivator PC4 family
uniprot
proteins
pubmed
11389848
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16415882
uniprot
proteins
pubmed
16605275
uniprot
proteins
pubmed
16689930
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
7628453
uniprot
proteins
pubmed
7809103
uniprot
proteins
pubmed
8062391
uniprot
proteins
pubmed
8062392
uniprot
proteins
pubmed
9360603
uniprot
proteins
pubmed
9482861
uniprot
proteins
sequence_length
127
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins