Gfi1
entrez
14581
canonical
uniprot
P70338
canonical
ensembl
ENSMUSG00000029275
resolver
ensp
ENSMUSP00000135039
resolver
ensp
ENSMUSP00000135884
resolver
ensp
ENSMUSP00000137229
resolver
enst
ENSMUST00000031205
resolver
enst
ENSMUST00000065478
resolver
enst
ENSMUST00000159164
resolver
genesymbol
Gfi1
resolver
genesymbol_syn
Gfi-1
resolver
uniprot
A0A0R4J292
resolver
uniprot
H3BJM0
resolver
uniprot
O09063
resolver
uniprot_entry
A0A0R4J292_MOUSE
resolver
uniprot_entry
GFI1_MOUSE
resolver
uniprot_entry
H3BJM0_MOUSE
resolver
uniprot_sec
O09063
resolver
amino_acid_sequence
MPRSFLVKSKKAHSYHQPRSPGPDYSLRLETVPAPGRAEGGAVSAGESKMEPRERLSPDSQLTEAPDRASASPNSCEGSVCDPCSEFEDFWRPPSPSVSPASEKSLCRSLDEAQPYTLPFKPYAWSGLAGSDLRHLVQSYRQCSALERSAGLSLFCERGSEPGRPAARYGPEQAAGGAGAGQPGRCGVAGGATSAAGLGLYGDFAPAAAGLYERPSTAAGRLYQDHGHELHADKSVGVKVESELLCTRLLLGGGSYKCIKCSKVFSTPHGLEVHVRRSHSGTRPFACEMCGKTFGHAVSLEQHKAVHSQERSFDCKICGKSFKRSSTLSTHLLIHSDTRPYPCQYCGKRFHQKSDMKKHTFIHTGEKPHKCQVCGKAFSQSSNLITHSRKHTGFKPFGCDLCGKGFQRKVDLRRHRETQHGLK
uniprot
proteins
function
FUNCTION: Transcription repressor essential for hematopoiesis (PubMed:8622900). Functions in a cell-context and development-specific manner (By similarity). Binds to 5'-TAAATCAC[AT]GCA-3' in the promoter region of a large number of genes (By similarity). Component of several complexes, including the EHMT2-GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (PubMed:17707228). Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required for granulocyte development (PubMed:17197705). Inhibits SPI1 transcriptional activity at macrophage-specific genes, repressing macrophage differentiation of myeloid progenitor cells and promoting granulocyte commitment (PubMed:17197705). Mediates, together with U2AF1L4, the alternative splicing of CD45 and controls T-cell receptor signaling (PubMed:16819553). Regulates the endotoxin-mediated Toll-like receptor (TLR) inflammatory response by antagonizing RELA (PubMed:20547752). Cooperates with CBFA2T2 to regulate ITGB1-dependent neurite growth (By similarity). Controls cell-cycle progression by repressing CDKNIA/p21 transcription in response to TGFB1 via recruitment of GFI1 by ZBTB17 to the CDKNIA/p21 and CDKNIB promoters (By similarity). Required for the maintenance of inner ear hair cells (PubMed:12441305). In addition to its role in transcription, acts as a substrate adapter for PRMT1 in the DNA damage response (PubMed:29651020). Facilitates the recognition of TP53BP1 and MRE11 substrates by PRMT1, promoting their methylation and the DNA damage response (By similarity). {ECO:0000250|UniProtKB:Q99684, ECO:0000269|PubMed:12441305, ECO:0000269|PubMed:16819553, ECO:0000269|PubMed:17197705, ECO:0000269|PubMed:17707228, ECO:0000269|PubMed:20547752, ECO:0000269|PubMed:29651020, ECO:0000269|PubMed:8622900}.
uniprot
proteins
mass_dalton
45944
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="P->A: Abrogates transcriptional repression. No change in nuclear location."; /evidence="ECO:0000269|PubMed:8887656"; MUTAGEN 3; /note="R->A: Partial loss of transcription repression. No change in nuclear location."; /evidence="ECO:0000269|PubMed:8887656"; MUTAGEN 4; /note="S->A: Partial loss of transcription repression. No change in nuclear location."; /evidence="ECO:0000269|PubMed:8887656"; MUTAGEN 10; /note="K->A: Abolishes most of the nuclear localization and reduces transcriptional repressor activity; when associated with A-11."; /evidence="ECO:0000269|PubMed:8887656"; MUTAGEN 11; /note="K->A: Abolishes most of the nuclear localization and reduces transcriptional repressor activity; when associated with A-10."; /evidence="ECO:0000269|PubMed:8887656
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. {ECO:0000250}.
uniprot
proteins
pubmed
12441305
uniprot
proteins
pubmed
16819553
uniprot
proteins
pubmed
17197705
uniprot
proteins
pubmed
17707228
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20547752
uniprot
proteins
pubmed
29651020
uniprot
proteins
pubmed
8622900
uniprot
proteins
pubmed
8887656
uniprot
proteins
pubmed
8985317
uniprot
proteins
sequence_length
423
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Note=Colocalizes with PIAS3 and RUNX1T1 in nuclear dots. {ECO:0000250}.
uniprot
proteins