Mafb
entrez
16658
canonical
uniprot
P54841
canonical
ensembl
ENSMUSG00000074622
resolver
ensp
ENSMUSP00000096728
resolver
enst
ENSMUST00000099126
resolver
genesymbol
Mafb
resolver
genesymbol_syn
Krml
resolver
genesymbol_syn
Maf1
resolver
uniprot
Q3U3C8
resolver
uniprot
Q3UPT9
resolver
uniprot_entry
MAFB_MOUSE
resolver
uniprot_sec
Q3U3C8
resolver
uniprot_sec
Q3UPT9
resolver
amino_acid_sequence
MAAELSMGQELPTSPLAMEYVNDFDLLKFDVKKEPLGRAERPGRPCTRLQPAGSVSSTPLSTPCSSVPSSPSFSPTEPKTHLEDLYWMASNYQQMNPEALNLTPEDAVEALIGSHPVPQPLQSFDGFRSAHHHHHHHHPHPHHGYPGAGVTHDDLGQHAHPHHHHHHQASPPPSSAASPAQQLPTSHPGPGPHATAAATAAGGNGSVEDRFSDDQLVSMSVRELNRHLRGFTKDEVIRLKQKRRTLKNRGYAQSCRYKRVQQKHHLENEKTQLIQQVEQLKQEVSRLARERDAYKVKCEKLANSGFREAGSTSDSPSSPEFFL
uniprot
proteins
function
FUNCTION: Acts as a transcriptional activator or repressor. Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain (PubMed:11823429). {ECO:0000250|UniProtKB:Q9Y5Q3, ECO:0000269|PubMed:10790365, ECO:0000269|PubMed:11823429, ECO:0000269|PubMed:16443760, ECO:0000269|PubMed:16847325, ECO:0000269|PubMed:17548468, ECO:0000269|PubMed:17901057, ECO:0000269|PubMed:18199433, ECO:0000269|PubMed:19143053, ECO:0000269|PubMed:19440205}.
uniprot
proteins
mass_dalton
35809
uniprot
proteins
mutagenesis
MUTAGEN 32; /note="K->R: Loss of SUMO modification, increases transactivation activity, increases macrophage differentiation and inhibits myeloid progenitor growth; when associated with R-297."; /evidence="ECO:0000269|PubMed:17548468"; MUTAGEN 248; /note="N->A: Reduces ability to activate insulin and glucagon gene expression."; /evidence="ECO:0000269|PubMed:18199433"; MUTAGEN 248; /note="N->S: Loss of transcriptional activity."; /evidence="ECO:0000269|PubMed:18199433"; MUTAGEN 297; /note="K->R: Loss of SUMO modification, increases transactivation activity, increases macrophage differentiation and inhibits myeloid progenitor growth; when associated with R-32."; /evidence="ECO:0000269|PubMed:17548468
uniprot
proteins
post_translational_modification
PTM: Sumoylated. Sumoylation on Lys-32 and Lys-297 stimulates its transcriptional repression activity and promotes macrophage differentiation from myeloid progenitors. {ECO:0000269|PubMed:17548468}.
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
protein_family
Maf subfamily
uniprot
proteins
pubmed
10383433
uniprot
proteins
pubmed
10721736
uniprot
proteins
pubmed
10790365
uniprot
proteins
pubmed
11823429
uniprot
proteins
pubmed
14513037
uniprot
proteins
pubmed
15135046
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16443760
uniprot
proteins
pubmed
16847325
uniprot
proteins
pubmed
16943423
uniprot
proteins
pubmed
17360442
uniprot
proteins
pubmed
17548468
uniprot
proteins
pubmed
17901057
uniprot
proteins
pubmed
17977745
uniprot
proteins
pubmed
18199433
uniprot
proteins
pubmed
19143053
uniprot
proteins
pubmed
19440205
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
27181683
uniprot
proteins
pubmed
8001130
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:15135046}.
uniprot
proteins