Mtcl2
entrez
320706
canonical
uniprot
E1U8D0
canonical
ensembl
ENSMUSG00000055485
resolver
ensp
ENSMUSP00000066556
resolver
ensp
ENSMUSP00000272325
resolver
ensp
ENSMUSP00000329436
resolver
genesymbol
Mtcl2
resolver
genesymbol_syn
Soga
resolver
genesymbol_syn
Soga1
resolver
uniprot
A2ACV6
resolver
uniprot_entry
MTCL2_MOUSE
resolver
uniprot_sec
A2ACV6
resolver
amino_acid_sequence
METPAGESSARGYGPPPAPAPAAERKKSHRAPSPARPKDVAGWSLAKGRRGTGPGSATACGTASSARPDKKGRAVAPGTRGTGPRVAGVRTGVRAKGRPRPGTGPRPPPPPPSLTDSSSEVSDCASEEARQLGLELALSSDAESAAGGPAGTRTGQPPQPAQSGQQPPRPPASPDEPSVAASSVGSSRLPLSASLAFSDLTEEMLDCGPGGLVRELEELRSENDYLKDEIEELRAEMLEMRDVYMEEDVYQLQELRQQLDQASKTCRILQYRLRKAERRSLRAAQTGQVDGELIRGLEQDVKVSKDISMRLHKELEVVEKKRMRLEEENEGLRQRLIETELAKQVLQTELDRPREHSLKKRGTRSLGKTDKKPTAQEDSADLKCQLHFAKEESALMCKKLTKLAKENDSMKEELLKYRSLYGDLDAALSAEELADAPHSRETELKVHLKLVEEEANLLSRRIVELEVENRGLRAEMDDMKDHGGGGGPEARLAFSSLGGECGESLAELRRHLQFVEEEAELLRRSSAELEDQNKLLLNELAKYRSEHELDVTLSEDSCSVLSEPSQEELAAAKLQIGELSGKVKKLQYENRVLLSNLQRCDLASCQSTRPMLETDAEAGDSAQCVPAPLGETLEPHAARLCRAREAEALPGLREQAALVSKAIDVLVADANGFSVGLRLCLDNECADLRLHEAPDNSEGPRDAKLIHAILVRLSVLQQELNAFTRKADVALGSSGKEQPEPFPALPALGSQGPAKEIMLSKDLGSDFQPPDFRDLLEWEPRIREAFRTGDLESKPDPSRNFRPYRAEDNDSYASEIKDLQLVLAEAHDSLRGLQEQLSQERQLRKEEADSFNQKMVQLKEDQQRALLRREFELQSLSLQRRLEQKFWSQEKNILVQESQQFKHNFLLLFMKLRWFLKRWRQGKVLPSEEDDFLEVNSMKELYLLMEEEEMNAQHSDNKACTGESWTQNTPNECIKTLADMKVTLKELCWLLQDERRGLTELQQQFAKAKATWETERAELKGHASQMELKAGKGASERPGPDWKAALQREREEQQHLLAESYSAVMELTRQLQLSERHWSQEKLQLVERLQGEKQQVEQQVKELQNRLSQLQKAAEPWVLKHSDMEKQDNSWKEARSEKTHDKEGVSEAELGGTGLKRTKSVSSMSEFESLLDCSPYLAGGDARNKKLPNGPAFAFVSTEPVEPEKDAKEKAGLSTRDCSHIGSLACQEPAGRQMQRSYTAPDKTGIRVYYSPPVARRLGVPVVHDKEGKILIEPGFLFTTAKPKESAEADGLAESSYSRWLCNFSRQRLDGGSGASTSGSGPAFPALHDFEMSGNMSDDMKEITNCVRQAMRSGSLERKVKNTSSQTVGVATVGTQTIRTVSVGLQTDPPRSSLHSKSWSPRSSSLVSVRSKQISSSLDKVHSRIERPCCSPKYGSPKLQRRSVSKLDSTKDRSLWNLHQGKQNGSAWARSTTTRDSPVLRNINDGLSSLFSVVEHSGSTESVWKLGMSEARTKPEPPKYGIVQEFFRNVCGRAPSPTTAAGEESCKKPEPLSPASYHQPEGVSRILNKKAAKAGGSEEVRPTMLSQVGKDGILRDGDGSLILPSEDAVCDCSAQSLASCFIRPSRNTIRHSPSKCRLHPSESGWGGEERAAPQ
uniprot
proteins
function
FUNCTION: Microtubule-associated factor that enables integration of the centrosomal and Golgi-associated microtubules on the Golgi membrane, supporting directional migration. Preferentially acts on the perinuclear microtubules accumulated around the Golgi. Associates with the Golgi membrane through the N-terminal coiled-coil region and directly binds microtubules through the C-terminal domain (PubMed:35543016). Required for faithful chromosome segregation during mitosis (By similarity). Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner (PubMed:20813965). {ECO:0000250|UniProtKB:O94964, ECO:0000269|PubMed:20813965, ECO:0000269|PubMed:35543016}.
uniprot
proteins
mass_dalton
183145
uniprot
proteins
mutagenesis
MUTAGEN 212..233; /note="LVRELEELRSENDYLKDEIEEL->AVREAEELRSENDYAKDEIEEA,PVREPEELRSENDYPKDEIEEP: Loss of association with Golgi apparatus membrane."; /evidence="ECO:0000269|PubMed:35543016
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved into a C-terminal SOGA 25 kDa form that is detected in plasma (By similarity). Proteolytically cleaved in primary hepatocytes into a C-terminal SOGA 80 kDa form. {ECO:0000250|UniProtKB:O94964, ECO:0000269|PubMed:20813965}.; PTM: Phosphorylated during mitosis in a CDK1-dependent manner. {ECO:0000250|UniProtKB:O94964}.
uniprot
proteins
protein_family
MTCL family
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20813965
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28550165
uniprot
proteins
pubmed
35543016
uniprot
proteins
sequence_length
1654
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [C-terminal 80 kDa form]: Secreted {ECO:0000269|PubMed:20813965}. Note=Secreted in primary hepatocyte-conditioned media. {ECO:0000269|PubMed:20813965}.; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:28550165, ECO:0000269|PubMed:35543016}. Golgi apparatus membrane {ECO:0000269|PubMed:35543016}. Midbody {ECO:0000250|UniProtKB:O94964}. Note=Co-localizes with CLASP2 in microtubules. {ECO:0000269|PubMed:28550165}.
uniprot
proteins