Strit1
entrez
102637511
canonical
uniprot
P0DN83
canonical
ensembl
ENSMUSG00000103476
resolver
ensp
ENSMUSP00000147363
resolver
ensp
ENSMUSP00000364790
resolver
enst
ENSMUST00000192926
resolver
genesymbol
Strit1
resolver
uniprot_entry
DWORF_MOUSE
resolver
amino_acid_sequence
MAEKESTSPHLIVPILLLVGWIVGCIIVIYIVFF
uniprot
proteins
function
FUNCTION: Enhances the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by displacing ATP2A1/SERCA1 inhibitors, thereby acting as a key regulator of skeletal muscle activity (PubMed:26816378, PubMed:30299255). Also enhances the activity of the ATP2A2/SERCA2 ATPase (By similarity). Does not directly stimulate SERCA pump activity (PubMed:26816378). Binds preferentially to the phosphorylated E1 and E2 conformational forms of ATP2A2 which predominate at high Ca(2+) concentrations during the systolic phase of the cardiac cycle (PubMed:35605666). Competes with ATP2A2 inhibitor phospholamban (PLN) for binding to ATP2A2 and displaces PLN (By similarity). Can activate ATP2A2 directly in the absence of PLN (By similarity). Also enhances sarcoplasmic reticulum Ca(2+) uptake and myocyte contractility by displacing the SERCA inhibitory peptides sarcolipin (SLN) and myoregulin (MRLN) (PubMed:26816378, PubMed:30299255). {ECO:0000250|UniProtKB:P0DN84, ECO:0000269|PubMed:26816378, ECO:0000269|PubMed:30299255, ECO:0000269|PubMed:35605666}.
uniprot
proteins
mass_dalton
3815
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
26816378
uniprot
proteins
pubmed
30299255
uniprot
proteins
pubmed
31449798
uniprot
proteins
pubmed
35605666
uniprot
proteins
sequence_length
34
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane {ECO:0000269|PubMed:26816378}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins