EPHX1
entrez
2052
canonical
uniprot
P07099
canonical
ensembl
ENSG00000143819
resolver
ensp
ENSP00000272167
resolver
ensp
ENSP00000355802
resolver
ensp
ENSP00000480004
resolver
ensp
ENSP00000539526
resolver
ensp
ENSP00000539527
resolver
ensp
ENSP00000539528
resolver
ensp
ENSP00000539530
resolver
ensp
ENSP00000539531
resolver
ensp
ENSP00000539532
resolver
ensp
ENSP00000539533
resolver
ensp
ENSP00000539534
resolver
ensp
ENSP00000539536
resolver
ensp
ENSP00000539537
resolver
ensp
ENSP00000539539
resolver
ensp
ENSP00000539540
resolver
ensp
ENSP00000539544
resolver
ensp
ENSP00000539547
resolver
ensp
ENSP00000539548
resolver
ensp
ENSP00000539550
resolver
ensp
ENSP00000539551
resolver
ensp
ENSP00000539552
resolver
ensp
ENSP00000539553
resolver
ensp
ENSP00000539554
resolver
ensp
ENSP00000539556
resolver
ensp
ENSP00000539557
resolver
ensp
ENSP00000539558
resolver
ensp
ENSP00000539559
resolver
ensp
ENSP00000539560
resolver
ensp
ENSP00000539563
resolver
ensp
ENSP00000539564
resolver
ensp
ENSP00000539566
resolver
ensp
ENSP00000539571
resolver
ensp
ENSP00000539573
resolver
ensp
ENSP00000539580
resolver
ensp
ENSP00000539581
resolver
ensp
ENSP00000539582
resolver
ensp
ENSP00000539584
resolver
ensp
ENSP00000539585
resolver
ensp
ENSP00000539586
resolver
ensp
ENSP00000539587
resolver
ensp
ENSP00000539588
resolver
ensp
ENSP00000539589
resolver
ensp
ENSP00000615695
resolver
ensp
ENSP00000615696
resolver
ensp
ENSP00000615697
resolver
ensp
ENSP00000765571
resolver
enst
ENST00000272167
resolver
enst
ENST00000366837
resolver
enst
ENST00000614058
resolver
enst
ENST00000869469
resolver
enst
ENST00000869471
resolver
enst
ENST00000869473
resolver
enst
ENST00000869474
resolver
enst
ENST00000869475
resolver
enst
ENST00000869477
resolver
enst
ENST00000869478
resolver
enst
ENST00000869480
resolver
enst
ENST00000869481
resolver
enst
ENST00000869485
resolver
enst
ENST00000869488
resolver
enst
ENST00000869489
resolver
enst
ENST00000869491
resolver
enst
ENST00000869492
resolver
enst
ENST00000869493
resolver
enst
ENST00000869494
resolver
enst
ENST00000869495
resolver
enst
ENST00000869497
resolver
enst
ENST00000869498
resolver
enst
ENST00000869499
resolver
enst
ENST00000869500
resolver
enst
ENST00000869501
resolver
enst
ENST00000869505
resolver
enst
ENST00000869507
resolver
enst
ENST00000869512
resolver
enst
ENST00000869514
resolver
enst
ENST00000869521
resolver
enst
ENST00000869522
resolver
enst
ENST00000869523
resolver
enst
ENST00000869525
resolver
enst
ENST00000869526
resolver
enst
ENST00000869527
resolver
enst
ENST00000869528
resolver
enst
ENST00000869529
resolver
enst
ENST00000869530
resolver
enst
ENST00000945636
resolver
enst
ENST00000945637
resolver
enst
ENST00000945638
resolver
genesymbol
EPHX1
resolver
genesymbol_syn
EPHX
resolver
genesymbol_syn
EPOX
resolver
hgnc
HGNC:3401
resolver
uniprot
A0A024R3P4
resolver
uniprot
B2R8N0
resolver
uniprot
Q5VTJ6
resolver
uniprot
Q9NP75
resolver
uniprot
Q9NPE7
resolver
uniprot
Q9NQU6
resolver
uniprot
Q9NQU7
resolver
uniprot
Q9NQU8
resolver
uniprot
Q9NQU9
resolver
uniprot
Q9NQV0
resolver
uniprot
Q9NQV1
resolver
uniprot
Q9NQV2
resolver
uniprot
R4SBI6
resolver
uniprot_entry
HYEP_HUMAN
resolver
uniprot_entry
R4SBI6_HUMAN
resolver
uniprot_sec
A0A024R3P4
resolver
uniprot_sec
B2R8N0
resolver
uniprot_sec
Q5VTJ6
resolver
uniprot_sec
Q9NP75
resolver
uniprot_sec
Q9NPE7
resolver
uniprot_sec
Q9NQU6
resolver
uniprot_sec
Q9NQU7
resolver
uniprot_sec
Q9NQU8
resolver
uniprot_sec
Q9NQU9
resolver
uniprot_sec
Q9NQV0
resolver
uniprot_sec
Q9NQV1
resolver
uniprot_sec
Q9NQV2
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by 10-hydroxystearamide and methoxy-arachidonyl fluorophosphate. {ECO:0000269|PubMed:24958911}.
uniprot
proteins
amino_acid_sequence
MWLEILLTSVLGFAIYWFISRDKEETLPLEDGWWGPGTRSAAREDDSIRPFKVETSDEEIHDLHQRIDKFRFTPPLEDSCFHYGFNSNYLKKVISYWRNEFDWKKQVEILNRYPHFKTKIEGLDIHFIHVKPPQLPAGHTPKPLLMVHGWPGSFYEFYKIIPLLTDPKNHGLSDEHVFEVICPSIPGYGFSEASSKKGFNSVATARIFYKLMLRLGFQEFYIQGGDWGSLICTNMAQLVPSHVKGLHLNMALVLSNFSTLTLLLGQRFGRFLGLTERDVELLYPVKEKVFYSLMRESGYMHIQCTKPDTVGSALNDSPVGLAAYILEKFSTWTNTEFRYLEDGGLERKFSLDDLLTNVMLYWTTGTIISSQRFYKENLGQGWMTQKHERMKVYVPTGFSAFPFELLHTPEKWVRFKYPKLISYSYMVRGGHFAAFEEPELLAQDIRKFLSVLERQ
uniprot
proteins
disease_involvement
DISEASE: Note=In some populations, the high activity haplotype tyr113/his139 is overrepresented among women suffering from pregnancy-induced hypertension (pre-eclampsia) when compared with healthy controls. {ECO:0000269|PubMed:12173035}.; DISEASE: Note=Variations in EPHX1 gene non-coding regions have been observed in a patient with hypercholanemia. The pathogenicity of these variants has not been confirmed. {ECO:0000269|PubMed:12878321}.
uniprot
proteins
ec_number
3.3.2.9
uniprot
proteins
function
FUNCTION: Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water (By similarity). Plays a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids (PubMed:22798687). Metabolizes the abundant endocannabinoid 2-arachidonoylglycerol (2-AG) to free arachidonic acid (AA) and glycerol (PubMed:24958911). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity). {ECO:0000250|UniProtKB:P07687, ECO:0000250|UniProtKB:Q9D379, ECO:0000269|PubMed:22798687, ECO:0000269|PubMed:24958911}.
uniprot
proteins
mass_dalton
52949
uniprot
proteins
protein_family
Peptidase S33 family
uniprot
proteins
pubmed
11058921
uniprot
proteins
pubmed
12173035
uniprot
proteins
pubmed
12878321
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15535985
uniprot
proteins
pubmed
15618730
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22798687
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24958911
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
2891713
uniprot
proteins
pubmed
3502697
uniprot
proteins
pubmed
7516776
uniprot
proteins
pubmed
7835893
uniprot
proteins
sequence_length
455
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000269|PubMed:24958911}; Single-pass type III membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P07687}; Single-pass type III membrane protein {ECO:0000250|UniProtKB:P07687}.
uniprot
proteins
transmembrane_region
TRANSMEM 1..21; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000250|UniProtKB:P07687
uniprot
proteins