MPC2
entrez
25874
canonical
uniprot
O95563
canonical
ensembl
ENSG00000143158
resolver
ensp
ENSP00000271373
resolver
ensp
ENSP00000356820
resolver
ensp
ENSP00000526517
resolver
ensp
ENSP00000526518
resolver
ensp
ENSP00000526519
resolver
ensp
ENSP00000526520
resolver
ensp
ENSP00000526521
resolver
ensp
ENSP00000606527
resolver
ensp
ENSP00000606528
resolver
ensp
ENSP00000606529
resolver
ensp
ENSP00000606530
resolver
enst
ENST00000271373
resolver
enst
ENST00000367846
resolver
enst
ENST00000856458
resolver
enst
ENST00000856459
resolver
enst
ENST00000856460
resolver
enst
ENST00000856461
resolver
enst
ENST00000856462
resolver
enst
ENST00000936468
resolver
enst
ENST00000936469
resolver
enst
ENST00000936470
resolver
enst
ENST00000936471
resolver
genesymbol
MPC2
resolver
genesymbol_syn
BRP44
resolver
hgnc
HGNC:24515
resolver
uniprot
A8K261
resolver
uniprot
Q3SXR6
resolver
uniprot
Q6FIF3
resolver
uniprot_entry
MPC2_HUMAN
resolver
uniprot_sec
A8K261
resolver
uniprot_sec
Q3SXR6
resolver
uniprot_sec
Q6FIF3
resolver
amino_acid_sequence
MSAAGARGLRATYHRLLDKVELMLPEKLRPLYNHPAGPRTVFFWAPIMKWGLVCAGLADMARPAEKLSTAQSAVLMATGFIWSRYSLVIIPKNWSLFAVNFFVGAAGASQLFRIWRYNQELKAKAHK
uniprot
proteins
function
FUNCTION: Mediates the uptake of pyruvate into mitochondria to maintain the balance between glycolysis and oxidative phosphorylation (PubMed:22628558, PubMed:26253029, PubMed:27317664, PubMed:29472561, PubMed:40044865, PubMed:40101766, PubMed:35278701). Plays an essential role in cellular metabolism (PubMed:40044865, PubMed:40101766). {ECO:0000269|PubMed:22628558, ECO:0000269|PubMed:26253029, ECO:0000269|PubMed:27317664, ECO:0000269|PubMed:29472561, ECO:0000269|PubMed:35278701, ECO:0000269|PubMed:40044865, ECO:0000269|PubMed:40101766}.
uniprot
proteins
mass_dalton
14279
uniprot
proteins
mutagenesis
MUTAGEN 49; /note="K->A: Impairs pyruvate uptake."; /evidence="ECO:0000269|PubMed:40101766"; MUTAGEN 66; /note="K->A: Impairs pyruvate uptake."; /evidence="ECO:0000269|PubMed:40101766"; MUTAGEN 71; /note="Q->A: Abolishes pyruvate uptake."; /evidence="ECO:0000269|PubMed:40101766"; MUTAGEN 82; /note="W->A: Impairs pyruvate uptake."; /evidence="ECO:0000269|PubMed:40101766"; MUTAGEN 100; /note="N->A: Impairs pyruvate uptake."; /evidence="ECO:0000269|PubMed:40101766"; MUTAGEN 110; /note="Q->A: Abolishes pyruvate uptake."; /evidence="ECO:0000269|PubMed:40101766
uniprot
proteins
protein_family
Mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22628558
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26253029
uniprot
proteins
pubmed
27317664
uniprot
proteins
pubmed
29472561
uniprot
proteins
pubmed
32403431
uniprot
proteins
pubmed
35278701
uniprot
proteins
pubmed
40044865
uniprot
proteins
pubmed
40101766
uniprot
proteins
sequence_length
127
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:22628558, ECO:0000269|PubMed:26253029, ECO:0000269|PubMed:29472561}; Multi-pass membrane protein {ECO:0000269|PubMed:40044865, ECO:0000269|PubMed:40101766}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..61; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:40044865, ECO:0000269|PubMed:40101766, ECO:0007744|PDB:8YW6, ECO:0007744|PDB:8YW8, ECO:0007744|PDB:8YW9, ECO:0007744|PDB:9KNW, ECO:0007744|PDB:9KNX, ECO:0007744|PDB:9KNY, ECO:0007744|PDB:9MNW, ECO:0007744|PDB:9MNX, ECO:0007744|PDB:9MNY, ECO:0007744|PDB:9MNZ, ECO:0007744|PDB:9MO0"; TRANSMEM 70..90; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:40044865, ECO:0000269|PubMed:40101766, ECO:0007744|PDB:8YW6, ECO:0007744|PDB:8YW8, ECO:0007744|PDB:8YW9, ECO:0007744|PDB:9KNW, ECO:0007744|PDB:9KNX, ECO:0007744|PDB:9KNY, ECO:0007744|PDB:9MNW, ECO:0007744|PDB:9MNX, ECO:0007744|PDB:9MNY, ECO:0007744|PDB:9MNZ, ECO:0007744|PDB:9MO0"; TRANSMEM 94..115; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:40044865, ECO:0000269|PubMed:40101766, ECO:0007744|PDB:8YW6, ECO:0007744|PDB:8YW8, ECO:0007744|PDB:8YW9, ECO:0007744|PDB:9KNW, ECO:0007744|PDB:9KNX, ECO:0007744|PDB:9KNY, ECO:0007744|PDB:9MNW, ECO:0007744|PDB:9MNX, ECO:0007744|PDB:9MNY, ECO:0007744|PDB:9MNZ, ECO:0007744|PDB:9MO0
uniprot
proteins