SCN10A
entrez
6336
canonical
uniprot
Q9Y5Y9
canonical
ensembl
ENSG00000185313
resolver
ensp
ENSP00000390600
resolver
ensp
ENSP00000495595
resolver
enst
ENST00000449082
resolver
genesymbol
SCN10A
resolver
hgnc
HGNC:10582
resolver
uniprot
A6NDQ1
resolver
uniprot_entry
SCNAA_HUMAN
resolver
uniprot_sec
A6NDQ1
resolver
amino_acid_sequence
MEFPIGSLETNNFRRFTPESLVEIEKQIAAKQGTKKAREKHREQKDQEEKPRPQLDLKACNQLPKFYGELPAELIGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSVHSWFSLFITVTILVNCVCMTRTDLPEKIEYVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMAVNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGKIYMIFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKFQEALEMLRKEQEVLAALGIDTTSLHSHNGSPLTSKNASERRHRIKPRVSEGSTEDNKSPRSDPYNQRRMSFLGLASGKRRASHGSVFHFRSPGRDISLPEGVTDDGVFPGDHESHRGSLLLGGGAGQQGPLPRSPLPQPSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDAGQKKTFLSAEYLDEPFRAQRAMSVVSIITSVLEELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELTITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSLLELGVAKKGSLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGEWIENMWACMEVGQKSICLILFLTVMVLGNLVVLNLFIALLLNSFSADNLTAPEDDGEVNNLQVALARIQVFGHRTKQALCSFFSRSCPFPQPKAEPELVVKLPLSSSKAENHIAANTARGSSGGLQAPRGPRDEHSDFIANPTVWVSVPIAEGESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQQVERCGDHLTPRSPGTGTSSEDLAPSLGETWKDESVPQVPAEGVDDTSSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGCIRHCPCCKLDTTKSPWDVGWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWCWLDFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCINYTDGEFSLVPLSIVNNKSDCKIQNSTGSFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALRQYYFTNGWNVFDFIVVVLSIASLIFSAILKSLQSYFSPTLFRVIRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSSFPHVRWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEATQFITFSALSDFADTLSGPLRIPKPNRNILIQMDLPLVPGDKIHCLDILFAFTKNVLGESGELDSLKANMEEKFMATNLSKSSYEPIATTLRWKQEDISATVIQKAYRSYVLHRSMALSNTPCVPRAEEEAASLPDEGFVAFTANENCVLPDKSETASATSFPPSYESVTRGLSDRVNMRTSSSIQNEDEATSMELIAPGP
uniprot
proteins
disease_involvement
DISEASE: Episodic pain syndrome, familial, 2 (FEPS2) [MIM:615551]: An autosomal dominant neurologic disorder characterized by adult-onset of paroxysmal pain mainly affecting the distal lower extremities. {ECO:0000269|PubMed:23115331}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms. {ECO:0000269|PubMed:23115331, ECO:0000269|PubMed:9839820}.
uniprot
proteins
mass_dalton
220626
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by NEDD4L; which promotes its endocytosis. {ECO:0000250}.; PTM: Phosphorylation at Ser-1451 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents. {ECO:0000250}.; PTM: Lacks the cysteine which covalently binds the conotoxin GVIIJ. This cysteine (position 816) is speculated in other sodium channel subunits alpha to be implied in covalent binding with the sodium channel subunit beta-2 or beta-4. {ECO:0000250|UniProtKB:P15389}.
uniprot
proteins
protein_family
Nav1.8/SCN10A subfamily
uniprot
proteins
protein_family
Sodium channel (TC 1.A.1.10) family
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
21248752
uniprot
proteins
pubmed
23115331
uniprot
proteins
pubmed
9839820
uniprot
proteins
sequence_length
1956
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:D0E0C2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:D0E0C2}. Note=It can be translocated to the cell membrane through association with S100A10. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 126..149; /note="Helical; Name=S1 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 155..174; /note="Helical; Name=S2 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 188..206; /note="Helical; Name=S3 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 213..232; /note="Helical; Voltage-sensor; Name=S4 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 249..272; /note="Helical; Name=S5 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 374..399; /note="Helical; Name=S6 of repeat I"; /evidence="ECO:0000255"; TRANSMEM 660..684; /note="Helical; Name=S1 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 696..719; /note="Helical; Name=S2 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 728..747; /note="Helical; Name=S3 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 754..773; /note="Helical; Voltage-sensor; Name=S4 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 790..810; /note="Helical; Name=S5 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 865..890; /note="Helical; Name=S6 of repeat II"; /evidence="ECO:0000255"; TRANSMEM 1148..1171; /note="Helical; Name=S1 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1185..1210; /note="Helical; Name=S2 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1217..1238; /note="Helical; Name=S3 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1243..1264; /note="Helical; Voltage-sensor; Name=S4 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1284..1311; /note="Helical; Name=S5 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1392..1418; /note="Helical; Name=S6 of repeat III"; /evidence="ECO:0000255"; TRANSMEM 1472..1495; /note="Helical; Name=S1 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1507..1530; /note="Helical; Name=S2 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1537..1560; /note="Helical; Name=S3 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1573..1594; /note="Helical; Voltage-sensor; Name=S4 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1610..1632; /note="Helical; Name=S5 of repeat IV"; /evidence="ECO:0000255"; TRANSMEM 1698..1722; /note="Helical; Name=S6 of repeat IV"; /evidence="ECO:0000255
uniprot
proteins