CLCA2
entrez
9635
canonical
uniprot
Q9UQC9
canonical
ensembl
ENSG00000137975
resolver
ensp
ENSP00000359596
resolver
enst
ENST00000370565
resolver
genesymbol
CLCA2
resolver
genesymbol_syn
CACC3
resolver
hgnc
HGNC:2016
resolver
uniprot
A8K2T3
resolver
uniprot
Q9Y6N2
resolver
uniprot_entry
CLCA2_HUMAN
resolver
uniprot_sec
A8K2T3
resolver
uniprot_sec
Q9Y6N2
resolver
amino_acid_sequence
MTQRSIAGPICNLKFVTLLVALSSELPFLGAGVQLQDNGYNGLLIAINPQVPENQNLISNIKEMITEASFYLFNATKRRVFFRNIKILIPATWKANNNSKIKQESYEKANVIVTDWYGAHGDDPYTLQYRGCGKEGKYIHFTPNFLLNDNLTAGYGSRGRVFVHEWAHLRWGVFDEYNNDKPFYINGQNQIKVTRCSSDITGIFVCEKGPCPQENCIISKLFKEGCTFIYNSTQNATASIMFMQSLSSVVEFCNASTHNQEAPNLQNQMCSLRSAWDVITDSADFHHSFPMNGTELPPPPTFSLVQAGDKVVCLVLDVSSKMAEADRLLQLQQAAEFYLMQIVEIHTFVGIASFDSKGEIRAQLHQINSNDDRKLLVSYLPTTVSAKTDISICSGLKKGFEVVEKLNGKAYGSVMILVTSGDDKLLGNCLPTVLSSGSTIHSIALGSSAAPNLEELSRLTGGLKFFVPDISNSNSMIDAFSRISSGTGDIFQQHIQLESTGENVKPHHQLKNTVTVDNTVGNDTMFLVTWQASGPPEIILFDPDGRKYYTNNFITNLTFRTASLWIPGTAKPGHWTYTLNNTHHSLQALKVTVTSRASNSAVPPATVEAFVERDSLHFPHPVMIYANVKQGFYPILNATVTATVEPETGDPVTLRLLDDGAGADVIKNDGIYSRYFFSFAANGRYSLKVHVNHSPSISTPAHSIPGSHAMYVPGYTANGNIQMNAPRKSVGRNEEERKWGFSRVSSGGSFSVLGVPAGPHPDVFPPCKIIDLEAVKVEEELTLSWTAPGEDFDQGQATSYEIRMSKSLQNIQDDFNNAILVNTSKRNPQQAGIREIFTFSPQISTNGPEHQPNGETHESHRIYVAIRAMDRNSLQSAVSNIAQAPLFIPPNSDPVPARDYLILKGVLTAMGLIGIICLIIVVTHHTLSRKKRADKKENGTKLL
uniprot
proteins
ec_number
3.4.-.-
uniprot
proteins
function
FUNCTION: Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4. {ECO:0000269|PubMed:10554024, ECO:0000269|PubMed:11320086, ECO:0000269|PubMed:11445004, ECO:0000269|PubMed:15707651, ECO:0000269|PubMed:16158324}.
uniprot
proteins
mass_dalton
103941
uniprot
proteins
mutagenesis
MUTAGEN 150; /note="N->Q: Reduction in size by around 2 kDa."; /evidence="ECO:0000269|PubMed:10362588"; MUTAGEN 292; /note="N->Q: No change in size."; /evidence="ECO:0000269|PubMed:10362588"; MUTAGEN 522; /note="N->Q: Reduction in size by around 2 kDa."; /evidence="ECO:0000269|PubMed:10362588"; MUTAGEN 637; /note="N->Q: No change in size."; /evidence="ECO:0000269|PubMed:10362588"; MUTAGEN 822; /note="N->Q: Reduction in size by around 2 kDa."; /evidence="ECO:0000269|PubMed:10362588"; MUTAGEN 938; /note="N->Q: No change in size."; /evidence="ECO:0000269|PubMed:10362588
uniprot
proteins
post_translational_modification
PTM: The 141 kDa mature form is autoproteolytically cleaved by the metalloprotease domain, producing a 109 kDa form and a 35 kDa form. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity. {ECO:0000250|UniProtKB:A8K7I4}.; PTM: N-glycosylated. {ECO:0000269|PubMed:10362588, ECO:0000269|PubMed:16873362}.
uniprot
proteins
protein_family
CLCR family
uniprot
proteins
pubmed
10362588
uniprot
proteins
pubmed
10437792
uniprot
proteins
pubmed
10554024
uniprot
proteins
pubmed
11262615
uniprot
proteins
pubmed
11320086
uniprot
proteins
pubmed
11445004
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14966209
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15707651
uniprot
proteins
pubmed
16158324
uniprot
proteins
pubmed
16873362
uniprot
proteins
pubmed
16959974
uniprot
proteins
sequence_length
943
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Basal cell membrane; Single-pass type I membrane protein. Cell junction.; SUBCELLULAR LOCATION: [Calcium-activated chloride channel regulator 2, 109 kDa form]: Secreted. Note=Remains associated to the 35 kDa form until an unidentified event triggers the release.
uniprot
proteins
transmembrane_region
TRANSMEM 902..922; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins