MIS18A
entrez
54069
canonical
uniprot
Q9NYP9
canonical
ensembl
ENSG00000159055
resolver
ensp
ENSP00000290130
resolver
enst
ENST00000290130
resolver
genesymbol
MIS18A
resolver
genesymbol_syn
C21orf45
resolver
genesymbol_syn
C21orf46
resolver
genesymbol_syn
FASP1
resolver
hgnc
HGNC:1286
resolver
uniprot
B2R562
resolver
uniprot
Q542Z0
resolver
uniprot_entry
MS18A_HUMAN
resolver
uniprot_sec
B2R562
resolver
uniprot_sec
Q542Z0
resolver
amino_acid_sequence
MAGVRSLRCSRGCAGGCECGDKGKCSDSSLLGKRLSEDSSRHQLLQKWASMWSSMSEDASVADMERAQLEEEAAAAEERPLVFLCSGCRRPLGDSLSWVASQEDTNCILLRCVSCNVSVDKEQKLSKREKENGCVLETLCCAGCSLNLGYVYRCTPKNLDYKRDLFCLSVEAIESYVLGSSEKQIVSEDKELFNLESRVEIEKSLTQMEDVLKALQMKLWEAESKLSFATCKS
uniprot
proteins
function
FUNCTION: Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis. {ECO:0000269|PubMed:17199038}.
uniprot
proteins
mass_dalton
25863
uniprot
proteins
mutagenesis
MUTAGEN 82; /note="V->E: Abolishes interaction with OIP5; when associated with D-176."; /evidence="ECO:0000269|PubMed:26921242"; MUTAGEN 85; /note="C->A: Abolishes location at the centromere."; /evidence="ECO:0000269|PubMed:17199038"; MUTAGEN 88; /note="C->A: Abolishes location at the centromere."; /evidence="ECO:0000269|PubMed:17199038"; MUTAGEN 134; /note="C->A: No effect."; /evidence="ECO:0000269|PubMed:17199038"; MUTAGEN 141; /note="C->A: Abolishes location at the centromere."; /evidence="ECO:0000269|PubMed:17199038"; MUTAGEN 144; /note="C->A: Abolishes location at the centromere."; /evidence="ECO:0000269|PubMed:17199038"; MUTAGEN 176; /note="Y->D: Abolishes interaction with OIP5; when associated with E-82."; /evidence="ECO:0000269|PubMed:26921242
uniprot
proteins
protein_family
Mis18 family
uniprot
proteins
pubmed
10773462
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
17199038
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26921242
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
233
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17199038}. Chromosome {ECO:0000269|PubMed:17199038}. Chromosome, centromere {ECO:0000269|PubMed:17199038}. Note=Associated with centromeres in interphase cells, from late anaphase to the G1 phase. Not detected on centromeres during earlier phases of mitosis. Associated with chromatin.
uniprot
proteins