O55126
uniprot
O55126
canonical
amino_acid_sequence
MAARVLLARGGLLRPAAQSAFLPGLRTVTSSSHRAREDSWLKSLFVRKVDPRKDAHSNLLAKKETSSLYKLQFHNVKPECLDAYNKICQEVLPKIHEGKQYPCTLVGTWNTWYGEQDQAVHLWRYEGGYPALTEVMNKLKENQEFVNFRKARSDMLLSRKNQLLLEFSFWNEPVPRPGPNIYELRSYQLRPGTMIEWGNYWARAIRFRQDSNEAIGGFFSQIGQLYMVDHLWAYRDLQTREDIRNAAWHKHGWEELVYYTVPLIQEMESRIMIPLKTSPLQ
uniprot
proteins
function
FUNCTION: Protein involved in mitophagy by facilitating recruitment of the autophagy machinery required for clearance of damaged mitochondria (PubMed:30982665). Accumulates on the mitochondria surface in response to mitochondrial depolarization and acts as a 'eat me' signal by recruiting proteins involved in selective autophagy, such as autophagy receptors (CALCOCO2/NDP52, NBR1, SQSTM1/p62, TAX1BP1 and WDFY3/ALFY) and ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2) (By similarity). May act as a positive regulator of L-type calcium channels (PubMed:22627147). {ECO:0000250|UniProtKB:O75323, ECO:0000269|PubMed:22627147, ECO:0000269|PubMed:30982665}.
uniprot
proteins
mass_dalton
32933
uniprot
proteins
protein_family
NipSnap family
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22627147
uniprot
proteins
pubmed
30982665
uniprot
proteins
pubmed
9661659
uniprot
proteins
sequence_length
281
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:O75323}. Cytoplasm {ECO:0000305|PubMed:22627147}.
uniprot
proteins