NFKBIE
entrez
4794
canonical
uniprot
O00221
canonical
ensembl
ENSG00000146232
resolver
ensp
ENSP00000275015
resolver
ensp
ENSP00000480216
resolver
enst
ENST00000275015
resolver
enst
ENST00000619360
resolver
genesymbol
NFKBIE
resolver
genesymbol_syn
IKBE
resolver
hgnc
HGNC:7799
resolver
uniprot
B7Z728
resolver
uniprot
Q5T9V9
resolver
uniprot
Q7LC14
resolver
uniprot
Q96F31
resolver
uniprot_entry
B7Z728_HUMAN
resolver
uniprot_entry
IKBE_HUMAN
resolver
uniprot_entry
Q7LC14_HUMAN
resolver
uniprot_entry
Q96F31_HUMAN
resolver
uniprot_sec
Q5T9V9
resolver
amino_acid_sequence
MNQRRSESRPGNHRLQAYAEPGKGDSGGAGPLSGSARRGRGGGGAIRVRRPCWSGGAGRGGGPAWAVRLPTVTAGWTWPALRTLSSLRAGPSEPHSPGRRPPRAGRPLCQADPQPGKAARRSLEPDPAQTGPRPARAAGMSEARKGPDEAEESQYDSGIESLRSLRSLPESTSAPASGPSDGSPQPCTHPPGPVKEPQEKEDADGERADSTYGSSSLTYTLSLLGGPEAEDPAPRLPLPHVGALSPQQLEALTYISEDGDTLVHLAVIHEAPAVLLCCLALLPQEVLDIQNNLYQTALHLAVHLDQPGAVRALVLKGASRALQDRHGDTALHVACQRQHLACARCLLEGRPEPGRGTSHSLDLQLQNWQGLACLHIATLQKNQPLMELLLRNGADIDVQEGTSGKTALHLAVETQERGLVQFLLQAGAQVDARMLNGCTPLHLAAGRGLMGISSTLCKAGADSLLRNVEDETPQDLTEESLVLLPFDDLKISGKLLLCTD
uniprot
proteins
function
FUNCTION: Sequesters NF-kappa-B transcription factor complexes in the cytoplasm, thereby inhibiting their activity (PubMed:9315679). Sequestered complexes include NFKB1-RELA (p50-p65) and NFKB1-REL (p50-c-Rel) complexes (PubMed:9135156, PubMed:9315679). Limits B-cell activation in response to pathogens, and also plays an important role in B-cell development (By similarity). {ECO:0000250|UniProtKB:O54910, ECO:0000269|PubMed:9135156, ECO:0000269|PubMed:9315679}.
uniprot
proteins
mass_dalton
52864
uniprot
proteins
mutagenesis
MUTAGEN 145; /note="K->R: No effect."; /evidence="ECO:0000269|PubMed:9135156"; MUTAGEN 157; /note="S->A: No degradation."; /evidence="ECO:0000269|PubMed:9135156"; MUTAGEN 161; /note="S->A: No degradation."; /evidence="ECO:0000269|PubMed:9135156
uniprot
proteins
post_translational_modification
PTM: Serine phosphorylated; followed by proteasome-dependent degradation.
uniprot
proteins
protein_family
NF-kappa-B inhibitor family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
37643469
uniprot
proteins
pubmed
9135156
uniprot
proteins
pubmed
9315679
uniprot
proteins
sequence_length
500
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9135156}.
uniprot
proteins