Stx17
entrez
252853
canonical
uniprot
Q9Z158
canonical
ensembl
ENSRNOG00000005801
resolver
ensembl
ENSRNOG00055020921
resolver
ensembl
ENSRNOG00060005213
resolver
ensembl
ENSRNOG00065010689
resolver
ensp
ENSRNOP00000007641
resolver
ensp
ENSRNOP00055028960
resolver
ensp
ENSRNOP00060006498
resolver
ensp
ENSRNOP00065013250
resolver
enst
ENSRNOT00000007641
resolver
enst
ENSRNOT00055035702
resolver
enst
ENSRNOT00060008650
resolver
enst
ENSRNOT00065017306
resolver
genesymbol
Stx17
resolver
uniprot_entry
STX17_RAT
resolver
amino_acid_sequence
MSEDEEKVKLRRLEPAIQKFTKIVIPTDLERLKKHQINIEKYQRCRIWDKLHEEHINAGRTVQQLRSNIREMEKLCLKVHKDDLILLKRMIDPMKEAAAAATAEFLQLHLESVEELKKQVKNEEALLQPSLTRSTTIDGVHTGEAEAASQSLTQIYALPEIPRDQNAAESWETLEADLIELSHLVTDMSLLVNSQQEKIDSIADHVNSAAVNVEEGTKNLQKAAKYKLAALPVAGAVIGGVVGGPIGLLAGFKVAGIAAALGGGVLGFTGGKLIQRRKQKMMEKLTSSCPDLPSQSDKKCS
uniprot
proteins
function
FUNCTION: SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (By similarity). {ECO:0000250|UniProtKB:P56962}.
uniprot
proteins
mass_dalton
33182
uniprot
proteins
mutagenesis
MUTAGEN 156; /note="Y->E: Alters interaction with COPB1 but not with SEC24C."; /evidence="ECO:0000269|PubMed:21545355, ECO:0000269|PubMed:23006999"; MUTAGEN 156; /note="Y->F: Prevents phosphorylation by ABL1 and impairs transport from the endoplasmic reticulum to the endoplasmic reticulum-Golgi intermediate compartment."; /evidence="ECO:0000269|PubMed:21545355, ECO:0000269|PubMed:23006999
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Tyr-156 probably by ABL1. Dephosphorylation by PTPN2; regulates exit from the endoplasmic reticulum. {ECO:0000269|PubMed:23006999}.
uniprot
proteins
protein_family
Syntaxin family
uniprot
proteins
pubmed
10930465
uniprot
proteins
pubmed
21545355
uniprot
proteins
pubmed
23006999
uniprot
proteins
pubmed
9852078
uniprot
proteins
sequence_length
301
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21545355}; Multi-pass membrane protein {ECO:0000255}. Smooth endoplasmic reticulum membrane {ECO:0000269|PubMed:10930465}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:21545355}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:P56962}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000269|PubMed:10930465}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, cytosol {ECO:0000269|PubMed:10930465}. Mitochondrion membrane {ECO:0000250|UniProtKB:P56962}; Multi-pass membrane protein {ECO:0000255}. Autolysosome membrane {ECO:0000250|UniProtKB:P56962}; Multi-pass membrane protein {ECO:0000255}. Note=Has a hairpin-like insertion into membranes. Localized into endoplasmic reticulum membranes, it also localizes to the completed autophagosome membrane upon cell starvation (By similarity). Colocalized with RAB39A and RAB39B in autolysosomes in autophagy-induced conditions (By similarity). {ECO:0000250|UniProtKB:P56962}.
uniprot
proteins
transmembrane_region
TRANSMEM 228..248; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 254..274; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins