FLRT2
entrez
23768
canonical
uniprot
O43155
canonical
ensembl
ENSG00000185070
resolver
ensp
ENSP00000332879
resolver
ensp
ENSP00000451050
resolver
ensp
ENSP00000507088
resolver
ensp
ENSP00000507815
resolver
ensp
ENSP00000562951
resolver
ensp
ENSP00000562952
resolver
ensp
ENSP00000562953
resolver
ensp
ENSP00000626336
resolver
ensp
ENSP00000626337
resolver
enst
ENST00000330753
resolver
enst
ENST00000554746
resolver
enst
ENST00000682132
resolver
enst
ENST00000683129
resolver
enst
ENST00000892892
resolver
enst
ENST00000892893
resolver
enst
ENST00000892894
resolver
enst
ENST00000956277
resolver
enst
ENST00000956278
resolver
genesymbol
FLRT2
resolver
genesymbol_syn
KIAA0405
resolver
hgnc
HGNC:3761
resolver
uniprot
A0AV84
resolver
uniprot
B7ZLP3
resolver
uniprot_entry
FLRT2_HUMAN
resolver
uniprot_sec
A0AV84
resolver
uniprot_sec
B7ZLP3
resolver
amino_acid_sequence
MGLQTTKWPSHGAFFLKSWLIISLGLYSQVSKLLACPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFSNLRKLERLDISNNQLRMLTQGVFDNLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSCPTTTPGLPLFTPAPSTASPTTQPPTLSIPNPSRSYTPPTPTTSKLPTIPDWDGRERVTPPISERIQLSIHFVNDTSIQVSWLSLFTVMAYKLTWVKMGHSLVGGIVQERIVSGEKQHLSLVNLEPRSTYRICLVPLDAFNYRAVEDTICSEATTHASYLNNGSNTASSHEQTTSHSMGSPFLLAGLIGGAVIFVLVVLLSVFCWHMHKKGRYTSQKWKYNRGRRKDDYCEAGTKKDNSILEMTETSFQIVSLNNDQLLKGDFRLQPIYTPNGGINYTDCHIPNNMRYCNSSVPDLEHCHT
uniprot
proteins
function
FUNCTION: Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis. {ECO:0000250|UniProtKB:Q8BLU0}.
uniprot
proteins
mass_dalton
74049
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:10644439, ECO:0000269|PubMed:19159218}.; PTM: Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain. Cleavage is probably effected by a metalloprotease. {ECO:0000250|UniProtKB:Q8BLU0}.
uniprot
proteins
pubmed
10644439
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
9455477
uniprot
proteins
sequence_length
660
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8BLU0}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q8BLU0}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8BLU0}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q8BLU0}. Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q8BLU0}. Microsome membrane {ECO:0000250|UniProtKB:Q8BLU0}. Secreted {ECO:0000250|UniProtKB:Q8BLU0}. Synapse, synaptosome {ECO:0000250|UniProtKB:D3ZTV3}. Note=Proteolytic cleavage gives rise to a shedded ectodomain. {ECO:0000250|UniProtKB:Q8BLU0}.
uniprot
proteins
transmembrane_region
TRANSMEM 542..562; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins