Cdc23
entrez
52563
canonical
uniprot
Q8BGZ4
canonical
ensembl
ENSMUSG00000024370
resolver
ensp
ENSMUSP00000025228
resolver
ensp
ENSMUSP00000122420
resolver
enst
ENSMUST00000025228
resolver
enst
ENSMUST00000133181
resolver
genesymbol
Cdc23
resolver
genesymbol_syn
Anapc8
resolver
uniprot
A0A0R4J1W7
resolver
uniprot
G3X8W7
resolver
uniprot
Q6PD06
resolver
uniprot
Q8C0F1
resolver
uniprot_entry
A0A0R4J1W7_MOUSE
resolver
uniprot_entry
CDC23_MOUSE
resolver
uniprot_entry
G3X8W7_MOUSE
resolver
uniprot_sec
Q6PD06
resolver
uniprot_sec
Q8C0F1
resolver
amino_acid_sequence
MAANSSVVSVAAAATAVPGVSTVADFSDLQEIKKQLLLIAGLTRERGLLHSSKWSAELAFSLPALPLSELQPPPPLTEEDAQDVDAYTLAKAYFDVKEYDRAAHFLHGCNSKKAYFLYMYSRYLSGEKKKDDETVDSLGPLEKGQVKNEALRELRVELSRKHQARGLDGFGLYLYGVVLRKLDLVKEAIDVFVEATHVLPLHWGAWLELCNLITDKEMLKFLSLPDTWMKEFFLAHIYTELQLIEEALQKYQHLIDVGFSKSSYIVSQIAVAYHNIRDIDKALSIFNELRKQDPYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRAYAVGDVEKKALVKLAKLHEQLTESEQAAQCYIKYIQDIYSCGETVEHLEESTAFRYLAQYYFKCKLWDEASTCAQKCCAFNDTREEGKALLRQILQLRNQGETPTSDTPGTFFLPASLSANNTPTRRVSPLNLSSVTP
uniprot
proteins
function
FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (By similarity). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (By similarity). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (By similarity). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (By similarity). {ECO:0000250|UniProtKB:Q9UJX2}.
uniprot
proteins
mass_dalton
68562
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9UJX2}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation on Thr-562 occurs specifically during mitosis (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
APC8/CDC23 family
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
597
uniprot
proteins