Slc17a9
entrez
228993
canonical
uniprot
Q8VCL5
canonical
ensembl
ENSMUSG00000023393
resolver
ensp
ENSMUSP00000091771
resolver
enst
ENSMUST00000094218
resolver
genesymbol
Slc17a9
resolver
uniprot
A2AJ51
resolver
uniprot
Q9DA66
resolver
uniprot_entry
Q9DA66_MOUSE
resolver
uniprot_entry
S17A9_MOUSE
resolver
uniprot_sec
A2AJ51
resolver
activity_regulation
ACTIVITY REGULATION: Activity is chloride-dependent. {ECO:0000250|UniProtKB:Q9BYT1}.
uniprot
proteins
amino_acid_sequence
MPSQRSSLMQPIPEETRKTPSAAAEDTRWSRPECQAWTGILLLGTCLLYCARVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEKVILLSASAWGFITVTTPLLAHLGSGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQESERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGLTLLWAYYVYRYLLNEKDLVLALGFLAQGLPVTKPSKVPWRQLFRKASVWAAICSQLCSACSFFILLSWLPTFFKETFPNSKGWVFNVVPWMLAIPASLFSGFISDRLISQGYRVITVRKFMQVMGLGLSSIFALCLGHTTSFLKAMIFASASIGFQTFNHSGISVNIQDLAPSCAGFLFGVANTAGALAGVVGVCLSGYLIETTGSWTCVFHLVAIISNLGLGTFLVFGKAQRVDLVPTHEDL
uniprot
proteins
function
FUNCTION: Voltage-gated ATP nucleotide uniporter that can also transport the purine nucleotides ADP and GTP. Uses the membrane potential as the driving force to control ATP accumulation in lysosomes and secretory vesicles (PubMed:23876310, PubMed:24962569, PubMed:27477609). By controlling ATP storage in lysosomes, regulates ATP-dependent proteins of these organelles (PubMed:23832620, PubMed:24962569, PubMed:27477609). Also indirectly regulates the exocytosis of ATP through its import into lysosomes in astrocytes and secretory vesicles such as adrenal chromaffin granules, mucin granules and synaptic vesicles (By similarity). {ECO:0000250|UniProtKB:Q9BYT1, ECO:0000269|PubMed:23832620, ECO:0000269|PubMed:23876310, ECO:0000269|PubMed:24962569, ECO:0000269|PubMed:27477609}.
uniprot
proteins
mass_dalton
48479
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Sodium/anion cotransporter family
uniprot
proteins
pubmed
18375752
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23832620
uniprot
proteins
pubmed
23876310
uniprot
proteins
pubmed
24962569
uniprot
proteins
pubmed
27477609
uniprot
proteins
sequence_length
447
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000269|PubMed:18375752}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:18375752}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:23876310, ECO:0000269|PubMed:24962569}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to mucin granules and vesicles. {ECO:0000250|UniProtKB:Q9BYT1}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..60; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 74..94; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 103..123; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 129..149; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 169..189; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 192..212; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 252..272; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 287..307; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 327..347; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 380..400; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 413..433; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins