Grem1
entrez
50566
canonical
uniprot
O35793
canonical
ensembl
ENSRNOG00000026053
resolver
ensembl
ENSRNOG00055002564
resolver
ensembl
ENSRNOG00060020085
resolver
ensembl
ENSRNOG00065015738
resolver
ensp
ENSRNOP00000035888
resolver
ensp
ENSRNOP00000084612
resolver
ensp
ENSRNOP00000102329
resolver
ensp
ENSRNOP00055003077
resolver
ensp
ENSRNOP00055003080
resolver
ensp
ENSRNOP00060028516
resolver
ensp
ENSRNOP00060028528
resolver
ensp
ENSRNOP00065020543
resolver
ensp
ENSRNOP00065020549
resolver
enst
ENSRNOT00000037895
resolver
enst
ENSRNOT00000104302
resolver
enst
ENSRNOT00000133512
resolver
enst
ENSRNOT00055004073
resolver
enst
ENSRNOT00055004076
resolver
enst
ENSRNOT00060034725
resolver
enst
ENSRNOT00060034741
resolver
enst
ENSRNOT00065026125
resolver
enst
ENSRNOT00065026131
resolver
genesymbol
Grem1
resolver
genesymbol_syn
Cktsf1b1
resolver
genesymbol_syn
Drm
resolver
uniprot_entry
GREM1_RAT
resolver
amino_acid_sequence
MNRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPPQPGSRTRGRGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD
uniprot
proteins
function
FUNCTION: Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (By similarity). Acts as inhibitor of monocyte chemotaxis (PubMed:15528323). Can inhibit the growth or viability of normal cells but not transformed cells when is overexpressed. {ECO:0000250|UniProtKB:O60565, ECO:0000250|UniProtKB:O70326, ECO:0000269|PubMed:15528323, ECO:0000269|PubMed:9234736}.
uniprot
proteins
mass_dalton
20680
uniprot
proteins
mutagenesis
MUTAGEN 42..44; /note="NDS->IEA: No interaction with SLIT1."; /evidence="ECO:0000269|PubMed:15528323
uniprot
proteins
protein_family
DAN family
uniprot
proteins
pubmed
15528323
uniprot
proteins
pubmed
9234736
uniprot
proteins
sequence_length
184
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
uniprot
proteins