Syt12
entrez
171180
canonical
uniprot
Q920N7
canonical
ensembl
ENSMUSG00000049303
resolver
ensp
ENSMUSP00000055237
resolver
enst
ENSMUST00000059295
resolver
genesymbol
Syt12
resolver
uniprot
Q14AG7
resolver
uniprot_entry
Q14AG7_MOUSE
resolver
uniprot_entry
SYT12_MOUSE
resolver
amino_acid_sequence
MAVDVTEYHLSVIKSPPGWEVGVYAAGALALLGIAAVSLWKLWTSGSFPSPSPFPNYDYRYLQQKYGEAYVEAKLKRVPPWNDQRTTTRGPPSRKGSLSIEDTFESISELGPLELMGRELDLAPYGTLRKSQSADSLNSISSVSNTFGQDFTLGQVEVSMDYDGASHTLHVAVLQGKDLLEREEATFESCFMRVSLLPDEQIVGISRIQRNAYSIFFDEKFSVPLDPTALEEKSLRFSVFGIDEDERNVSTGVVELKLSVLDLPLQPFSGWLYLQDQNKAADAVGEILLSLSYLPTAERLTVVVVKAKNLIWTNEKSTADPFVKVYLLQDGRKMSKKKTAVKRDDPNPVFNEAMIFSVPAIVLQDLSLRVTVAESSSDGRGDNVGHVIIGPGVSGMGTTHWNQMLATLRRPVSMWHPVRRN
uniprot
proteins
function
FUNCTION: Synaptic vesicle phosphoprotein that enhances spontaneous neurotransmitter release but does not effect induced neurotransmitter release (By similarity). Unlike other synaptotagmins, it does not bind Ca(2+) or phospholipids (By similarity). Essential for mossy-fiber long-term potentiation in the hippocampus (PubMed:23739973). {ECO:0000250|UniProtKB:P97610, ECO:0000269|PubMed:23739973}.
uniprot
proteins
mass_dalton
46680
uniprot
proteins
mutagenesis
MUTAGEN 97; /note="S->A: Loss of phosphorylation by PKA. Reduces long-term potentiation in mossy-fiber synapses in the hippocampus but has no effect on short-term potentiation. Inhibits the effect of forskolin on synaptic transmission and inhibitory post-synaptic currents. No effect on excitatory and inhibitory synaptic transmission in the hippocampus. No effect on brain structure."; /evidence="ECO:0000269|PubMed:23739973
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Ser-97 is required for mossy-fiber long-term potentiation. {ECO:0000269|PubMed:23739973}.
uniprot
proteins
protein_family
Synaptotagmin family
uniprot
proteins
pubmed
11514560
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17190793
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23739973
uniprot
proteins
sequence_length
421
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:17190793}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 19..39; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins