Il21
entrez
60505
canonical
uniprot
Q9ES17
canonical
ensembl
ENSMUSG00000027718
resolver
ensp
ENSMUSP00000029273
resolver
ensp
ENSMUSP00000124668
resolver
enst
ENSMUST00000029273
resolver
enst
ENSMUST00000161015
resolver
genesymbol
Il21
resolver
uniprot
E9PX58
resolver
uniprot
Q5SUE2
resolver
uniprot_entry
E9PX58_MOUSE
resolver
uniprot_entry
IL21_MOUSE
resolver
uniprot_entry
Q5SUE2_MOUSE
resolver
amino_acid_sequence
MERTLVCLVVIFLGTVAHKSSPQGPDRLLIRLRHLIDIVEQLKIYENDLDPELLSAPQDVKGHCEHAAFACFQKAKLKPSNPGNNKTFIIDLVAQLRRRLPARRGGKKQKHIAKCPSCDSYEKRTPKEFLERLKWLLQKMIHQHLS
uniprot
proteins
function
FUNCTION: Cytokine with immunoregulatory activity. May promote the transition between innate and adaptive immunity. Induces the production of IgG(1) and IgG(3) in B-cells (PubMed:15100251). Implicated in the generation and maintenance of T follicular helper (Tfh) cells and the formation of germinal-centers. Together with IL6, control the early generation of Tfh cells and are critical for an effective antibody response to acute viral infection (PubMed:23045607). May play a role in proliferation and maturation of natural killer (NK) cells in synergy with IL15 (PubMed:11970879). May regulate proliferation of mature B- and T-cells in response to activating stimuli. In synergy with IL15 and IL18 stimulates interferon gamma production in T-cells and NK cells (By similarity). During T-cell mediated immune response may inhibit dendritic cells (DC) activation and maturation (PubMed:12893770). {ECO:0000250|UniProtKB:Q9HBE4, ECO:0000269|PubMed:11970879, ECO:0000269|PubMed:12893770, ECO:0000269|PubMed:15100251, ECO:0000269|PubMed:23045607}.
uniprot
proteins
mass_dalton
16811
uniprot
proteins
protein_family
IL-15/IL-21 family
uniprot
proteins
pubmed
11081504
uniprot
proteins
pubmed
11970879
uniprot
proteins
pubmed
12893770
uniprot
proteins
pubmed
15100251
uniprot
proteins
pubmed
23045607
uniprot
proteins
sequence_length
146
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11970879}.
uniprot
proteins