P2rx1
entrez
25505
canonical
uniprot
P47824
canonical
ensembl
ENSRNOG00000017606
resolver
ensembl
ENSRNOG00055027418
resolver
ensembl
ENSRNOG00060018550
resolver
ensembl
ENSRNOG00065025037
resolver
ensp
ENSRNOP00000024068
resolver
ensp
ENSRNOP00000073411
resolver
ensp
ENSRNOP00055039092
resolver
ensp
ENSRNOP00060026000
resolver
ensp
ENSRNOP00065035303
resolver
enst
ENSRNOT00000024068
resolver
enst
ENSRNOT00000088245
resolver
enst
ENSRNOT00055047515
resolver
enst
ENSRNOT00060031979
resolver
enst
ENSRNOT00065043106
resolver
genesymbol
P2rx1
resolver
uniprot
A0ACM8Q292
resolver
uniprot
A6HGH4
resolver
uniprot
B7U2F3
resolver
uniprot
Q9JIF8
resolver
uniprot_entry
A0ACM8Q292_RAT
resolver
uniprot_entry
A6HGH4_RAT
resolver
uniprot_entry
B7U2F3_RAT
resolver
uniprot_entry
P2RX1_RAT
resolver
uniprot_sec
Q9JIF8
resolver
activity_regulation
ACTIVITY REGULATION: Activated by low concentrations of ATP (<1 uM) (PubMed:7523951). Undergoes rapid desensitization. Sensitives to the ATP agonist:alpha/beta-methylene-ATP. Modulated by cholesterol (By similarity). {ECO:0000250|UniProtKB:P51575, ECO:0000269|PubMed:7523951}.
uniprot
proteins
amino_acid_sequence
MARRLQDELSAFFFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFVYEKGYQTSSDLISSVSVKLKGLAVTQLQGLGPQVWDVADYVFPAHGDSSFVVMTNFIVTPQQTQGHCAENPEGGICQDDSGCTPGKAERKAQGIRTGNCVPFNGTVKTCEIFGWCPVEVDDKIPSPALLREAENFTLFIKNSISFPRFKVNRRNLVEEVNGTYMKKCLYHKIQHPLCPVFNLGYVVRESGQDFRSLAEKGGVVGITIDWKCDLDWHVRHCKPIYQFHGLYGEKNLSPGFNFRFARHFVQNGTNRRHLFKVFGIHFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKRHYYKQKKFKYAEDMGPGEGEHDPVATSSTLGLQENMRTS
uniprot
proteins
function
FUNCTION: ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and with relatively high calcium permeability (PubMed:15686495, PubMed:7523951, PubMed:9606184). Furthermore, CTP functions as a weak affinity agonist for P2RX1 (By similarity). Plays a role a role in urogenital, immune and cardiovascular function (By similarity). Specifically, plays an important role in neurogenic contraction of smooth muscle of the vas deferens, and therefore is essential for normal male reproductive function (By similarity). In addition, contributes to smooth muscle contractions of the urinary bladder (By similarity). On platelets, contributes to platelet activation and aggregation and thereby, also to thrombosis (By similarity). On neutrophils, it is involved in chemotaxis and in mitigating the activation of circulating cells (By similarity). {ECO:0000250|UniProtKB:P51575, ECO:0000250|UniProtKB:P51576, ECO:0000269|PubMed:15686495, ECO:0000269|PubMed:7523951, ECO:0000269|PubMed:9606184}.
uniprot
proteins
mass_dalton
44957
uniprot
proteins
protein_family
P2X receptor family
uniprot
proteins
pubmed
15313628
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15686495
uniprot
proteins
pubmed
2072913
uniprot
proteins
pubmed
7523951
uniprot
proteins
pubmed
9606184
uniprot
proteins
pubmed
9855626
uniprot
proteins
sequence_length
399
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9606184}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P56373}. Note=Detected at plasma membrane lipid rafts. {ECO:0000250|UniProtKB:P51575}.
uniprot
proteins
transmembrane_region
TRANSMEM 29..50; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 339..358; /note="Helical; Name=2"; /evidence="ECO:0000255
uniprot
proteins