Srgap2
entrez
14270
canonical
uniprot
Q91Z67
canonical
ensembl
ENSMUSG00000026425
resolver
ensp
ENSMUSP00000095195
resolver
ensp
ENSMUSP00000229044
resolver
enst
ENSMUST00000097588
resolver
genesymbol
Srgap2
resolver
genesymbol_syn
Fbp27
resolver
genesymbol_syn
Fnbp2
resolver
uniprot
B2RY13
resolver
uniprot
Q3V1V8
resolver
uniprot
Q61054
resolver
uniprot_entry
SRGP2_MOUSE
resolver
uniprot_sec
B2RY13
resolver
uniprot_sec
Q3V1V8
resolver
uniprot_sec
Q61054
resolver
amino_acid_sequence
MTSPAKFKKDKEIIAEYDTQVKEIRAQLTEQMKCLDQQCELRVQLLQDLQDFFRKKAEIEMDYSRNLEKLAERFLAKTRSTKDQQFKKDQNVLSPVNCWNLLLNQVKRESRDHTTLSDIYLNNIIPRFVQVSEDSGRLFKKSKEVGQQLQDDLMKVLNELYSVMKTYHMYNADSISAQSKLKEAEKQEEKQIGKSVKQEDRQTPRSPDSTANVRIEEKHVRRSSVKKIEKMKEKRQAKYTENKLKAIKARNEYLLALEATNASVFKYYIHDLSDIIDQCCDLGYHASLNRALRTFLSAELNLEQSKHEGLDAIENAVENLDATSDKQRLMEMYNNVFCPPMKFEFQPHMGDMASQLCAQQPVQSELVQRCQQLQSRLSTLKIENEEVKKTMEATLQTIQDIVTVEDFDVSDCFQYSNSMESVKSTVSETFMSKPSIAKRRANQQETEQFYFTKMKEYLEGRNLITKLQAKHDLLQKTLGESQRTDCSLARRSSTVRKQDSSQAIPLVVESCIRFISRHGLQHEGIFRVSGSQVEVNDIKNAFERGEDPLAGDQNDHDMDSIAGVLKLYFRGLEHPLFPKDIFHDLIACVTMDNLQERAVHIRKVLLVLPKPTLIIMRYLFAFLNHLSQFSEENMMDPYNLAICFGPSLMSVPEGHDQVSCQAHVNELIKTIIIQHENIFPNPRELEGPIYSRGGSMEDYCDSTHGETTSAEDSTQDVTAEHHTSDDECEPIEAIAKFDYVGRTARELSFKKGASLLLYQRASDDWWEGRHNGIDGLIPHQYIVVQDTEDGVVERSSPKSEIEVMSEPPEEKVTARTGASCPSGGHVADIYLANINKQRKRPESGSIRKAFRSDSHGLGSSLTDSSSLGVGASCRPSSQPIMSQNLPKEGPDKCSISGHGSLNSISRHSSLKNRMDSPQIRKTATAGRSKSFNNHRPMDPEVIAQDIEATMNSALNELQELERQSSAKHTPDVVLDTLEPLKTSPVVAPTSEPSSPLHTQLLKDPEPAFQRSASTAGDIACAFRPVKSVKMAAPVKPPATRPKPTVFPKTNATSPGVNSSASPQATDKSCTV
uniprot
proteins
function
FUNCTION: Postsynaptic RAC1 GTPase activating protein (GAP) that plays a key role in neuronal morphogenesis and migration mainly during development of the cerebral cortex (PubMed:19737524, PubMed:22559944, PubMed:27373832). Regulates excitatory and inhibitory synapse maturation and density in cortical pyramidal neurons (PubMed:19737524, PubMed:22559944, PubMed:27373832). SRGAP2/SRGAP2A limits excitatory and inhibitory synapse density through its RAC1-specific GTPase activating activity, while it promotes maturation of both excitatory and inhibitory synapses through its ability to bind to the postsynaptic scaffolding protein HOMER1 at excitatory synapses, and the postsynaptic protein GPHN at inhibitory synapses (PubMed:27373832). Mechanistically, acts by binding and deforming membranes, thereby regulating actin dynamics to regulate cell migration and differentiation (PubMed:19737524, PubMed:22559944, PubMed:26439400). Promotes cell repulsion and contact inhibition of locomotion: localizes to protrusions with curved edges and controls the duration of RAC1 activity in contact protrusions (PubMed:26439400). In non-neuronal cells, may also play a role in cell migration by regulating the formation of lamellipodia and filopodia (PubMed:22559944). {ECO:0000269|PubMed:19737524, ECO:0000269|PubMed:22559944, ECO:0000269|PubMed:26439400, ECO:0000269|PubMed:27373832}.
uniprot
proteins
mass_dalton
120798
uniprot
proteins
mutagenesis
MUTAGEN 340..343; /note="PMKF->LMKC: Abolished interaction with HOMER1."; /evidence="ECO:0000269|PubMed:27373832"; MUTAGEN 527; /note="R->L: Abolished RAC1 GTPase activity. Abolished ability to induce neurite branching. No effect on filopodia biogenesis and neurite outgrowth."; /evidence="ECO:0000269|PubMed:19737524, ECO:0000269|PubMed:27373832"; MUTAGEN 765; /note="W->A: Loss of the ability to induce filopodia and to initiate neurite outgrowth. Abolished interaction with GPHN."; /evidence="ECO:0000269|PubMed:19737524, ECO:0000269|PubMed:27373832
uniprot
proteins
post_translational_modification
PTM: Methylation at Arg-927 is required for the stimulation of cell migration, dimerization and localization at the plasma membrane protrusions. {ECO:0000250|UniProtKB:O75044}.
uniprot
proteins
pubmed
11672528
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19737524
uniprot
proteins
pubmed
21148482
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22126966
uniprot
proteins
pubmed
22559944
uniprot
proteins
pubmed
26439400
uniprot
proteins
pubmed
27373832
uniprot
proteins
pubmed
8605874
uniprot
proteins
sequence_length
1071
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19737524}. Cell projection, dendritic spine {ECO:0000269|PubMed:27373832}. Postsynaptic density {ECO:0000269|PubMed:22559944}. Postsynaptic cell membrane {ECO:0000269|PubMed:22559944}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:O75044}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:21148482}. Nucleus {ECO:0000250|UniProtKB:D4A208}. Cytoplasm, cytosol {ECO:0000269|PubMed:21148482}. Note=Recruited to actin-rich phagosomes during phagocytosis (PubMed:21148482). Translocates from nucleus to cytoplasm during development (By similarity). {ECO:0000250|UniProtKB:D4A208, ECO:0000269|PubMed:21148482}.
uniprot
proteins