Aldh3b1
entrez
67689
canonical
uniprot
Q80VQ0
canonical
ensembl
ENSMUSG00000024885
resolver
ensp
ENSMUSP00000056276
resolver
enst
ENSMUST00000051803
resolver
genesymbol
Aldh3b1
resolver
genesymbol_syn
Aldh7
resolver
uniprot
Q3TX25
resolver
uniprot
Q63ZW3
resolver
uniprot
Q8VHW0
resolver
uniprot
Q9CW05
resolver
uniprot_entry
AL3B1_MOUSE
resolver
uniprot_entry
Q3TX25_MOUSE
resolver
uniprot_sec
Q63ZW3
resolver
uniprot_sec
Q8VHW0
resolver
uniprot_sec
Q9CW05
resolver
amino_acid_sequence
MDSFEDKLQQLREAFKEGRTRSAEFRAAQLQGLSHFLRDNKQQLQEALAQDLHKSAFEAEVSEIAISQAEVDLALRNLRSWMKDEKVSKNLATQLDSAFIRKEPFGLVLIIVPWNYPINLTLVPLVGAIAAGNCVVLKPSEISKATEKILAEVLPRYLDQSCFTVVLGGRQETGQLLEHKFDYIFFTGNAYVGKIVMAAAAKHLTPITLELGGKNPCYVDDNCDPQIVANRVAWFRYFNAGQTCVAPDYILCSQEMQERLVPALQNAITRFYGDNPQTSPNLGRIINQKHFKRLQGLLGCGRVAIGGQSDEGERYIAPTVLVDVQETEPVMQEEIFGPILPLVTVRSLDEAIEFMNRREKPLALYAFSKRSQVIKQVLARTSSGGFCGNDGFMHMTLSSLPFGGVGTSGMGRYHGKFSFDTFSNQRACLLRSPGMEKINDLRYPPYSSRNLRVLLVAMEERCCSCTLL
uniprot
proteins
ec_number
1.2.1.28
uniprot
proteins
ec_number
1.2.1.48
uniprot
proteins
ec_number
1.2.1.5
uniprot
proteins
ec_number
1.2.1.7
uniprot
proteins
function
FUNCTION: Oxidizes medium and long chain saturated and unsaturated fatty aldehydes generated in the plasma membrane into non-toxic fatty acids (PubMed:17382292, PubMed:25286108). May have a protective role against the cytotoxicity induced by lipid peroxidation. Short-chain fatty aldehydes are not good substrates. Can use both NADP(+) and NAD(+) as electron acceptor in vitro, however in vivo preference will depend on their tissue levels. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. Able to metabolize aromatic aldehydes such as benzaldehyde to their acid form (By similarity). {ECO:0000250|UniProtKB:P43353, ECO:0000269|PubMed:17382292, ECO:0000269|PubMed:25286108}.
uniprot
proteins
mass_dalton
52292
uniprot
proteins
mutagenesis
MUTAGEN 462..463; /note="CC->SS: Abolishes palmitoylation."; /evidence="ECO:0000269|PubMed:25286108"; MUTAGEN 462; /note="C->S: Reduces palmitoylation."; /evidence="ECO:0000269|PubMed:25286108"; MUTAGEN 463; /note="C->S: Reduces palmitoylation."; /evidence="ECO:0000269|PubMed:25286108
uniprot
proteins
pathway_participation
PATHWAY: Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
uniprot
proteins
post_translational_modification
PTM: Dually lipidated in the C-terminus; prenylation occurs prior to, and is a prerequisite for palmitoylation. It is also required for activity towards long-chain substrates. {ECO:0000269|PubMed:25286108}.
uniprot
proteins
protein_family
Aldehyde dehydrogenase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17382292
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25286108
uniprot
proteins
sequence_length
468
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25286108}; Lipid-anchor {ECO:0000269|PubMed:25286108}. Note=Primarily in the plasma membrane as well as in some punctate structures in the cytoplasm. {ECO:0000269|PubMed:25286108}.
uniprot
proteins