BIRC2
entrez
329
canonical
uniprot
Q13490
canonical
ensembl
ENSG00000110330
resolver
ensp
ENSP00000227758
resolver
ensp
ENSP00000431723
resolver
ensp
ENSP00000477613
resolver
genesymbol
BIRC2
resolver
genesymbol_syn
API1
resolver
genesymbol_syn
MIHB
resolver
genesymbol_syn
RNF48
resolver
hgnc
HGNC:590
resolver
uniprot
B4E026
resolver
uniprot
Q16516
resolver
uniprot
Q4TTG0
resolver
uniprot_entry
BIRC2_HUMAN
resolver
uniprot_sec
B4E026
resolver
uniprot_sec
Q16516
resolver
uniprot_sec
Q4TTG0
resolver
activity_regulation
ACTIVITY REGULATION: The CARD domain inhibits the activation of E3 ubiquitin ligase activity by preventing RING domain dimerization and E2 ubiquitin donor binding and activation. The CARD domain-mediated autoinhibition of the E3 ubiquitin-protein ligase activity suppresses cell proliferation and migration. USP19 regulates the stability of BIRC2/c-IAP1 by preventing its ubiquitination. {ECO:0000269|PubMed:21549626, ECO:0000269|PubMed:21849505}.
uniprot
proteins
amino_acid_sequence
MHKTASQRLFPGPSYQNIKSIMEDSTILSDWTNSNKQKMKYDFSCELYRMSTYSTFPAGVPVSERSLARAGFYYTGVNDKVKCFCCGLMLDNWKLGDSPIQKHKQLYPSCSFIQNLVSASLGSTSKNTSPMRNSFAHSLSPTLEHSSLFSGSYSSLSPNPLNSRAVEDISSSRTNPYSYAMSTEEARFLTYHMWPLTFLSPSELARAGFYYIGPGDRVACFACGGKLSNWEPKDDAMSEHRRHFPNCPFLENSLETLRFSISNLSMQTHAARMRTFMYWPSSVPVQPEQLASAGFYYVGRNDDVKCFCCDGGLRCWESGDDPWVEHAKWFPRCEFLIRMKGQEFVDEIQGRYPHLLEQLLSTSDTTGEENADPPIIHFGPGESSSEDAVMMNTPVVKSALEMGFNRDLVKQTVQSKILTTGENYKTVNDIVSALLNAEDEKREEEKEKQAEEMASDDLSLIRKNRMALFQQLTCVLPILDNLLKANVINKQEHDIIKQKTQIPLQARELIDTILVKGNAAANIFKNCLKEIDSTLYKNLFVDKNMKYIPTEDVSGLSLEEQLRRLQEERTCKVCMDKEVSVVFIPCGHLVVCQECAPSLRKCPICRGIIKGTVRTFLS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling, and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, RIPK2, RIPK3, RIPK4, CASP3, CASP7, CASP8, TRAF2, DIABLO/SMAC, MAP3K14/NIK, MAP3K5/ASK1, IKBKG/NEMO, IKBKE and MXD1/MAD1. Can also function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway, targeting effector caspases for neddylation and inactivation. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs), Nodlike receptors (NLRs) and RIG-I like receptors (RLRs), collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome, a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8. Can stimulate the transcriptional activity of E2F1. Plays a role in the modulation of the cell cycle. {ECO:0000269|PubMed:15665297, ECO:0000269|PubMed:18082613, ECO:0000269|PubMed:21145488, ECO:0000269|PubMed:21653699, ECO:0000269|PubMed:21931591, ECO:0000269|PubMed:23453969}.
uniprot
proteins
mass_dalton
69900
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated and degraded by the proteasome in apoptotic cells.; PTM: Upon stimulation of death receptors, including TNFRSF10B, recruited to receptors and cleaved by caspases. Proteolytic fragments remain associated with the receptors. This cleavage presumably inactivates the protein. {ECO:0000269|PubMed:18846110}.
uniprot
proteins
protein_family
IAP family
uniprot
proteins
pubmed
10404221
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15665297
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
18082613
uniprot
proteins
pubmed
18414036
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18846110
uniprot
proteins
pubmed
19153467
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20651737
uniprot
proteins
pubmed
20888210
uniprot
proteins
pubmed
21145488
uniprot
proteins
pubmed
21447281
uniprot
proteins
pubmed
21549626
uniprot
proteins
pubmed
21653699
uniprot
proteins
pubmed
21849505
uniprot
proteins
pubmed
21931591
uniprot
proteins
pubmed
22095281
uniprot
proteins
pubmed
23453969
uniprot
proteins
pubmed
25486457
uniprot
proteins
pubmed
25681446
uniprot
proteins
pubmed
8548810
uniprot
proteins
pubmed
8552191
uniprot
proteins
pubmed
8643514
uniprot
proteins
sequence_length
618
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Agents that induce either the extrinsic or intrinsic apoptotic pathways promote its redistribution from the nuclear compartment to the cytoplasmic compartment. Associated with the midbody in telophase cells, and found diffusely in the nucleus of interphase cells.
uniprot
proteins