Slc6a5
entrez
171148
canonical
uniprot
P58295
canonical
ensembl
ENSRNOG00000031662
resolver
ensembl
ENSRNOG00055002912
resolver
ensembl
ENSRNOG00060001487
resolver
ensembl
ENSRNOG00065009070
resolver
ensp
ENSRNOP00000043665
resolver
ensp
ENSRNOP00000105371
resolver
genesymbol
Slc6a5
resolver
genesymbol_syn
Glyt2
resolver
uniprot
F1LNM6
resolver
uniprot
Q6QDB3
resolver
uniprot_entry
SC6A5_RAT
resolver
uniprot_sec
F1LNM6
resolver
uniprot_sec
Q6QDB3
resolver
amino_acid_sequence
MDCSAPKEMNKPPTNILEATVPGHRDSPRAPRTSPEQDLPAAAPAAAVQPPRVPRSASTGAQTFQSADARACEAQRPGVGFCKLSSPQAQATSAALRDLSEGHSAQANPPSGAAGAGNALHCKIPALRGPEEDENVSVGKGTLEHNNTPAVGWVNMSQSTVVLGTDGIASVLPGSVATTTIPEDEQGDENKARGNWSSKLDFILSMVGYAVGLGNVWRFPYLAFQNGGGAFLIPYLMMLALAGLPIFFLEVSLGQFASQGPVSVWKAIPALQGCGIAMLIISVLIAIYYNVIICYTLFYLFASFVSVLPWGSCNNPWNTPECKDKTKLLLDSCVIGDHPKIQIKNSTFCMTAYPNLTMVNFTSQANKTFVSGSEEYFKYFVLKISAGIEYPGEIRWPLAFCLFLAWVIVYASLAKGIKTSGKVVYFTATFPYVVLVILLIRGVTLPGAGAGIWYFITPKWEKLTDATVWKDAATQIFFSLSAAWGGLITLSSYNKFHNNCYRDTLIVTCTNSATSIFAGFVIFSVIGFMANERKVNIENVADQGPGIAFVVYPEALTRLPLSPFWAIIFFLMLLTLGLDTMFATIETIVTSISDEFPKYLRTHKPVFTLGCCICFFIMGFPMITQGGIYMFQLVDTYAASYALVIIAIFELVGISYVYGLQRFCEDIEMMIGFQPNIFWKVCWAFVTPTILTFILCFSFYQWEPMTYGSYRYPNWSMVLGWLMLACSVIWIPIMFVIKMYLAPGRFIERLKLVCSPQPDWGPFLAQHRGERYKNMIDPLGTSSLGLKLPVKDLELGTQC
uniprot
proteins
function
FUNCTION: Sodium- and chloride-dependent glycine transporter (PubMed:25480793, PubMed:8226790, PubMed:40725001). Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals (PubMed:8226790). May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses (PubMed:8226790). {ECO:0000269|PubMed:25480793, ECO:0000269|PubMed:40725001, ECO:0000269|PubMed:8226790}.
uniprot
proteins
mass_dalton
87842
uniprot
proteins
mutagenesis
MUTAGEN 451; /note="G->E: Loss of glycine transport. Loss of localization to the cell membrane."; /evidence="ECO:0000269|PubMed:40725001"; MUTAGEN 512; /note="S->A: Decreased glycine transport."; /evidence="ECO:0000269|PubMed:25480793"; MUTAGEN 512; /note="S->C: Decreased glycine transport."; /evidence="ECO:0000269|PubMed:25480793"; MUTAGEN 512; /note="S->R: Loss of glycine transport. Retained in the endoplasmic reticulum due to defective processing and trafficking to the cell surface."; /evidence="ECO:0000269|PubMed:25480793"; MUTAGEN 512; /note="S->T: No effect on glycine transport."; /evidence="ECO:0000269|PubMed:25480793
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q9Y345}.
uniprot
proteins
protein_family
SLC6A5 subfamily
uniprot
proteins
protein_family
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
25480793
uniprot
proteins
pubmed
40725001
uniprot
proteins
pubmed
8226790
uniprot
proteins
sequence_length
799
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25480793, ECO:0000269|PubMed:40725001}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 202..222; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 230..249; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 273..293; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 396..414; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 423..440; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 476..493; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 505..526; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 559..578; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 606..624; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 640..660; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 681..700; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 719..737; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins