Arfgap1
entrez
246310
canonical
uniprot
Q62848
canonical
ensembl
ENSRNOG00000043150
resolver
ensp
ENSRNOP00000013900
resolver
ensp
ENSRNOP00000051916
resolver
ensp
ENSRNOP00000073451
resolver
enst
ENSRNOT00000013900
resolver
enst
ENSRNOT00000082267
resolver
genesymbol
Arfgap1
resolver
genesymbol_syn
Arf1gap
resolver
uniprot
A0A0G2K5J6
resolver
uniprot
A0A8L2Q6R4
resolver
uniprot
Q3S4A4
resolver
uniprot
Q3S4A5
resolver
uniprot_entry
A0A0G2K5J6_RAT
resolver
uniprot_entry
A0A8L2Q6R4_RAT
resolver
uniprot_entry
ARFG1_RAT
resolver
uniprot_entry
Q3S4A4_RAT
resolver
uniprot_entry
Q3S4A5_RAT
resolver
amino_acid_sequence
MASPRTRKVLKEVRAQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKWKDIELEKMKAGGNAKFREFLEAQDDYEPSWSLQDKYSSRAAALFRDKVATLAEGKEWSLESSPAQNWTPPQPKTLQFTAHRPAGQPQNVTTSGDKAFEDWLNDDLGSYQGAQENRYVGFGNTVPPQKREDDFLNSAMSSLYSGWSSFTTGASKFASAAKEGATKFGSQASQKASELGHSLNENVLKPAQEKVKEGRIFDDVSSGVSQLASKVQGVGSKGWRDVTTFFSGKAEDTSDRPLEGHSYQNSSGDNSQNSTIDQSFWETFGSAEPPKAKSPSSDSWTCADASTGRRSSDSWDIWGSGSASNNKNSNSDGWESWEGASGEGRAKATKKAAPSTAADEGWDNQNW
uniprot
proteins
function
FUNCTION: GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1) (PubMed:7890632, PubMed:8533093). Involved in membrane trafficking and /or vesicle transport (PubMed:19015319, PubMed:7890632, PubMed:8533093). Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment (PubMed:7890632, PubMed:8533093). Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2 (PubMed:11703931). Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated (PubMed:7890632). Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (PubMed:7890632). {ECO:0000269|PubMed:11703931, ECO:0000269|PubMed:19015319, ECO:0000269|PubMed:7890632, ECO:0000269|PubMed:8533093}.
uniprot
proteins
mass_dalton
45442
uniprot
proteins
mutagenesis
MUTAGEN 22; /note="C->A: Loss of GAP activity."; /evidence="ECO:0000269|PubMed:8533093, ECO:0000269|PubMed:9733781"; MUTAGEN 25; /note="C->A: Loss of GAP activity."; /evidence="ECO:0000269|PubMed:8533093
uniprot
proteins
pubmed
10102276
uniprot
proteins
pubmed
11703931
uniprot
proteins
pubmed
11748249
uniprot
proteins
pubmed
19015319
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7890632
uniprot
proteins
pubmed
8533093
uniprot
proteins
pubmed
9405360
uniprot
proteins
pubmed
9733781
uniprot
proteins
sequence_length
415
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:19015319, ECO:0000269|PubMed:8533093}. Cytoplasm {ECO:0000269|PubMed:8533093}. Note=Associates with the Golgi complex. {ECO:0000269|PubMed:8533093}.
uniprot
proteins