LIN7A
entrez
8825
canonical
uniprot
O14910
canonical
ensembl
ENSG00000111052
resolver
ensp
ENSP00000447488
resolver
ensp
ENSP00000547380
resolver
ensp
ENSP00000547381
resolver
ensp
ENSP00000664818
resolver
enst
ENST00000552864
resolver
enst
ENST00000877321
resolver
enst
ENST00000877322
resolver
genesymbol
LIN7A
resolver
genesymbol_syn
MALS1
resolver
genesymbol_syn
VELI1
resolver
hgnc
HGNC:17787
resolver
uniprot
A4FTY3
resolver
uniprot
Q147W1
resolver
uniprot
Q6LES3
resolver
uniprot
Q7LDS4
resolver
uniprot_entry
LIN7A_HUMAN
resolver
uniprot_sec
A4FTY3
resolver
uniprot_sec
Q147W1
resolver
uniprot_sec
Q6LES3
resolver
uniprot_sec
Q7LDS4
resolver
amino_acid_sequence
MLKPSVTSAPTADMATLTVVQPLTLDRDVARAIELLEKLQESGEVPVHKLQSLKKVLQSEFCTAIREVYQYMHETITVNGCPEFRARATAKATVAAFAASEGHSHPRVVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTPKVLEEMEARFEKLRTARRRQQQQLLIQQQQQQQQQQTQQNHMS
uniprot
proteins
function
FUNCTION: Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 associates with the motor protein KIF17 to transport vesicles containing N-methyl-D-aspartate (NMDA) receptor subunit NR2B along microtubules (By similarity). This complex may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. {ECO:0000250|UniProtKB:Q8JZS0, ECO:0000269|PubMed:12967566}.
uniprot
proteins
mass_dalton
25997
uniprot
proteins
protein_family
Lin-7 family
uniprot
proteins
pubmed
10341223
uniprot
proteins
pubmed
11311936
uniprot
proteins
pubmed
12967566
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17237226
uniprot
proteins
pubmed
9482110
uniprot
proteins
pubmed
9753324
uniprot
proteins
sequence_length
233
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8JZS0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8JZS0}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q8JZS0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8JZS0}. Cell junction {ECO:0000250|UniProtKB:Q8JZS0}. Postsynaptic density membrane {ECO:0000250|UniProtKB:Q8JZS0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8JZS0}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q8JZS0}. Note=Mainly basolateral in renal epithelial cells. {ECO:0000250|UniProtKB:Q8JZS0}.
uniprot
proteins