Cyp46a1
entrez
13116
canonical
uniprot
Q9WVK8
canonical
ensembl
ENSMUSG00000021259
resolver
ensp
ENSMUSP00000021684
resolver
enst
ENSMUST00000021684
resolver
genesymbol
Cyp46a1
resolver
genesymbol_syn
Cyp46
resolver
uniprot
Q3US73
resolver
uniprot_entry
CP46A_MOUSE
resolver
uniprot_entry
Q3US73_MOUSE
resolver
amino_acid_sequence
MSPGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPYFWKKDEDCGRVLQDVFLDWAKKYGPVVRVNVFYKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERLFGQGLVSECDYGRWYKQRKVMDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSMQDMLTCATIDILAKAAFGMETSMLLGAQKPLSQAVKVMLEGISASRNTLAKFMPGKRKQLREIRESIRLLRQVGKDWVQRRREALKRGEDMPADILTQILKAEEGAQDDEVLLDNFVTFFIAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVVGSKRHLDYEDLGRLQYLSQVLKESLRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRIEFRLVPGQRFGLQEQATLKPLDPVLCTLRPRGWQPAPPPPPC
uniprot
proteins
ec_number
1.14.14.25
uniprot
proteins
function
FUNCTION: P450 monooxygenase that plays a major role in cholesterol homeostasis in the brain. Primarily catalyzes the hydroxylation (with S stereochemistry) at C-24 of cholesterol side chain, triggering cholesterol diffusion out of neurons and its further degradation (PubMed:10377398, PubMed:16505352, PubMed:28190002). By promoting constant cholesterol elimination in neurons, may activate the mevalonate pathway and coordinate the synthesis of new cholesterol and nonsterol isoprenoids involved in synaptic activity and learning (PubMed:16505352). Further hydroxylates cholesterol derivatives and hormone steroids on both the ring and side chain of these molecules, converting them into active oxysterols involved in lipid signaling and biosynthesis (By similarity). Acts as an epoxidase converting cholesta-5,24-dien-3beta-ol/desmosterol into (24S),25-epoxycholesterol, an abundant lipid ligand of nuclear NR1H2 and NR1H3 receptors shown to promote neurogenesis in developing brain (By similarity). May also catalyze the oxidative metabolism of xenobiotics, such as clotrimazole (By similarity). {ECO:0000250|UniProtKB:Q9Y6A2, ECO:0000269|PubMed:10377398, ECO:0000269|PubMed:16505352, ECO:0000269|PubMed:28190002}.
uniprot
proteins
mass_dalton
56814
uniprot
proteins
pathway_participation
PATHWAY: Steroid metabolism; cholesterol degradation. {ECO:0000305|PubMed:28190002}.; PATHWAY: Lipid metabolism; C21-steroid hormone metabolism. {ECO:0000250|UniProtKB:Q9Y6A2}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
10377398
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16505352
uniprot
proteins
pubmed
18241055
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28190002
uniprot
proteins
sequence_length
500
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18241055}; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein. Postsynapse {ECO:0000269|PubMed:16505352}. Presynapse {ECO:0000269|PubMed:16505352}. Cell projection, dendrite {ECO:0000269|PubMed:18241055}.
uniprot
proteins
transmembrane_region
TRANSMEM 3..23; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins