Mmadhc
entrez
109129
canonical
uniprot
Q99LS1
canonical
ensembl
ENSMUSG00000026766
resolver
ensp
ENSMUSP00000099830
resolver
enst
ENSMUST00000102769
resolver
genesymbol
Mmadhc
resolver
uniprot_entry
MMAD_MOUSE
resolver
amino_acid_sequence
MAHVLCNRARLVSYLPGFCSLVKRVINPRAFSTAGSSGSDESHVATAPPDICSRTVWPDETMGPFGPQDQRFQLPGNIGFDCHLNGTASQKKSQAHKTLPDVLAEPLSTERHEFVMAQYVNEFQDSDAPVEQEINSAETYFESAKVECAIQTCPELLRRDFESLFPEVANSKLMILTVTQKTENDMTVWSEEVEVEREVLLEKFISGAKEICYALRAEGYWADFIDPSSGVAFFGPYTNNTLFETDERYRHLGFSVDDLGCCKVIRHSLWGTHVVVGSIFTNATADSSIMRKLSGN
uniprot
proteins
function
FUNCTION: Involved in cobalamin metabolism and trafficking. Plays a role in regulating the biosynthesis and the proportion of two coenzymes, methylcob(III)alamin (MeCbl) and 5'-deoxyadenosylcobalamin (AdoCbl). Promotes oxidation of cob(II)alamin bound to MMACHC. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine. {ECO:0000250|UniProtKB:Q9H3L0}.
uniprot
proteins
mass_dalton
32995
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
26483544
uniprot
proteins
sequence_length
296
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H3L0}. Mitochondrion {ECO:0000250|UniProtKB:Q9H3L0}.
uniprot
proteins