Q9QUH6
uniprot
Q9QUH6
canonical
amino_acid_sequence
MSRSRASIHRGSIPAMSYAPFRDVRGPPMHRTQYVHSPYDRPGWNPRFCIISGNQLLMLDEDEIHPLLIRDRRSESSRNKLLRRTVSVPVEGRPHGEHEYHLGRSRRKSVPGGKQYSMEAAPAAPFRPSQGFLSRRLKSSIKRTKSQPKLDRTSSFRQILPRFRSADHDRARLMQSFKESHSHESLLSPSSAAEALELNLDEDSIIKPVHSSILGQEFCFEVTTSSGTKCFACRSAAERDKWIENLQRAVKPNKDNSRRVDNVLKLWIIEARELPPKKRYYCELCLDDMLYARTTSKPRSASGDTVFWGEHFEFNNLPAVRALRLHLYRDSDKKRKKDKAGYVGLVTVPVATLAGRHFTEQWYPVTLPTGSGGSGGMGSGGGGGSGGGSGGKGKGGCPAVRLKARYQTMSILPMELYKEFAEYVTNHYRMLCAVLEPALNVKGKEEVASALVHILQSTGKAKDFLSDMAMSEVDRFMEREHLIFRENTLATKAIEEYMRLIGQKYLKDAIGEFIRALYESEENCEVDPIKCTASSLAEHQANLRMCCELALCKVVNSHCVFPRELKEVFASWRLRCAERGREDIADRLISASLFLRFLCPAIMSPSLFGLMQEYPDEQTSRTLTLIAKVIQNLANFSKFTSKEDFLGFMNEFLELEWGSMQQFLYEISNLDTLTNSSSFEGYIDLGRELSTLHALLWEVLPQLSKEALLKLGPLPRLLSDISTALRNPNIQRQPSRQSERARSQPMVLRGPSAEMQGYMMRDLNSSIDLQSFMARGLNSSMDMARLPSPTKEKPPPPPPGGGKDLFYVSRPPLARSSPAYCTSSSDITEPEQKMLSVNKSVSMLDLQGDGPGGRLNSSSVSNLAAVGDLLHSSQASLTAALGLRPAPAGRLSQGSGSSITAAGMRLSQMGVTTDGVPAQQLRIPLSFQNPLFHMAADGPGPPAGHGGSSGHGPPSSHHHHHHHHHHRGGEPPGDTFAPFHGYSKSEDLSTGVPKPPAASILHSHSYSDEFGPSGTDFTRRQLSLQDNLQHMLSPPQITIGPQRPAPSGPGGGSGGGSGGGGGGQPPPLQRGKSQQLTVSAAQKPRPSSGNLLQSPEPSYGPARPRQQSLSKEGSIGGSGGSGGGGGGGLKPSITKQHSQTPSTLNPTMPASERTVAWVSNMPHLSADIESAHIEREEYKLKEYSKSMDESRLDRVKEYEEEIHSLKERLHMSNRKLEEYERRLLSQEEQTSKILMQYQARLEQSEKRLRQQQVEKDSQIKSIIGRLMLVEEELRRDHPAMAEPLPEPKKRLLDAQRGSFPPWVQQTRV
uniprot
proteins
function
FUNCTION: Major constituent of the PSD essential for postsynaptic signaling. Inhibitory regulator of the Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity. Regulates AMPAR-mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap. May be involved in certain forms of brain injury, leading to long-term learning and memory deficits. {ECO:0000269|PubMed:15312654, ECO:0000269|PubMed:15500970, ECO:0000269|PubMed:16537406, ECO:0000269|PubMed:18323856}.
uniprot
proteins
mass_dalton
144722
uniprot
proteins
mutagenesis
MUTAGEN 385; /note="S->A: Affects stimulation by PLK2."; /evidence="ECO:0000269|PubMed:21382555"; MUTAGEN 449; /note="S->A: Affects stimulation by PLK2."; /evidence="ECO:0000269|PubMed:21382555"; MUTAGEN 485; /note="R->K: Decreases RapGAP activity by 100-fold."; /evidence="ECO:0000269|PubMed:18323856"; MUTAGEN 485; /note="R->P: Abolishes RapGAP activity."; /evidence="ECO:0000269|PubMed:18323856"; MUTAGEN 487; /note="N->T: Decreases RapGAP activity by 20-fold."; /evidence="ECO:0000269|PubMed:18323856"; MUTAGEN 840; /note="S->A: Blocks the gel mobility shift induced by PLK2 and affects stimulation by PLK2."; /evidence="ECO:0000269|PubMed:21382555"; MUTAGEN 842; /note="S->A: Blocks the gel mobility shift induced by PLK2."; /evidence="ECO:0000269|PubMed:21382555
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CaM-kinase II. Dephosphorylated upon NMDA receptor activation or SYNGAP1/MPDZ complex disruption. Phosphorylation by PLK2 promotes its activity. {ECO:0000269|PubMed:15312654, ECO:0000269|PubMed:21382555}.
uniprot
proteins
pubmed
11278737
uniprot
proteins
pubmed
15312654
uniprot
proteins
pubmed
15500970
uniprot
proteins
pubmed
16054660
uniprot
proteins
pubmed
16507876
uniprot
proteins
pubmed
16537406
uniprot
proteins
pubmed
18323856
uniprot
proteins
pubmed
21382555
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9581761
uniprot
proteins
pubmed
9620694
uniprot
proteins
sequence_length
1308
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein. Synapse. Note=Mostly in excitatory glutamatergic synapses.
uniprot
proteins