RPUSD4
entrez
84881
canonical
uniprot
Q96CM3
canonical
ensembl
ENSG00000165526
resolver
ensp
ENSP00000298317
resolver
ensp
ENSP00000433065
resolver
ensp
ENSP00000575301
resolver
genesymbol
RPUSD4
resolver
hgnc
HGNC:25898
resolver
uniprot
B4DUN4
resolver
uniprot
E9PML2
resolver
uniprot
Q96K56
resolver
uniprot_entry
B4DUN4_HUMAN
resolver
uniprot_entry
RUSD4_HUMAN
resolver
uniprot_sec
E9PML2
resolver
uniprot_sec
Q96K56
resolver
amino_acid_sequence
MAAPRWSASGPWIRGNGQGCGSLFTLVSKPFCAAAAASTAINAQRLAEKLRAQKREQDTKKEPVSTNAVQRRVQEIVRFTRQLQRVHPNVLAKALTRGILHQDKNLVVINKPYGLPVHGGPGVQLCITDVLPILAKMLHGHKAEPLHLCHRLDKETTGVMVLAWDKDMAHQVQELFRTRQVVKKYWAITVHVPMPSAGVVDIPIVEKEAQGQQQHHKMTLSPSYRMDDGKMVKVRRSRNAQVAVTQYQVLSSTLSSALVELQPITGIKHQLRVHLSFGLDCPILGDHKYSDWNRLAPQKLSVGTLKKLGLEQSKARYIPLHLHARQLILPALGSGKEELNLVCKLPRFFVHSLHRLRLEMPNEDQNENNEAKCLGAQ
uniprot
proteins
ec_number
5.4.99.-
uniprot
proteins
function
FUNCTION: Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates (PubMed:27974379, PubMed:28082677, PubMed:41136621). Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA) (PubMed:27974379, PubMed:41136621). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome (PubMed:27974379). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA, controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664). Acts on position 39 in mitochondrial tRNA(Phe) (PubMed:28082677). Also catalyzes pseudouridylation of mRNAs in nucleus: acts as a regulator of pre-mRNA splicing by mediating pseudouridylation of pre-mRNAs at locations associated with alternatively spliced regions (PubMed:35051350). Pseudouridylation of pre-mRNAs near splice sites directly regulates mRNA splicing and mRNA 3'-end processing (PubMed:35051350). {ECO:0000269|PubMed:27667664, ECO:0000269|PubMed:27974379, ECO:0000269|PubMed:28082677, ECO:0000269|PubMed:35051350, ECO:0000269|PubMed:41136621}.
uniprot
proteins
mass_dalton
42205
uniprot
proteins
protein_family
Pseudouridine synthase RluA family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
23435261
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27667664
uniprot
proteins
pubmed
27974379
uniprot
proteins
pubmed
28082677
uniprot
proteins
pubmed
35051350
uniprot
proteins
pubmed
41136621
uniprot
proteins
sequence_length
377
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:23435261, ECO:0000269|PubMed:27974379, ECO:0000269|PubMed:28082677}. Nucleus {ECO:0000269|PubMed:23435261}. Cytoplasm {ECO:0000269|PubMed:23435261}. Note=Mainly localizes to mitochondrion (PubMed:23435261, PubMed:27974379, PubMed:28082677). Localizes to mitochondrial RNA granules, platforms for post-transcriptional RNA modification and ribosome assembly (PubMed:27974379, PubMed:28082677). Also found in nucleus and cytoplasm (PubMed:23435261). {ECO:0000269|PubMed:23435261, ECO:0000269|PubMed:27974379, ECO:0000269|PubMed:28082677}.
uniprot
proteins