Spred2
entrez
305539
canonical
uniprot
Q3C2P8
canonical
ensembl
ENSRNOG00000004888
resolver
ensembl
ENSRNOG00055007678
resolver
ensembl
ENSRNOG00060014566
resolver
ensembl
ENSRNOG00065006055
resolver
ensp
ENSRNOP00000071793
resolver
ensp
ENSRNOP00000102473
resolver
ensp
ENSRNOP00055010239
resolver
ensp
ENSRNOP00060019846
resolver
ensp
ENSRNOP00065006557
resolver
enst
ENSRNOT00000079874
resolver
enst
ENSRNOT00000161751
resolver
enst
ENSRNOT00055012847
resolver
enst
ENSRNOT00060024913
resolver
enst
ENSRNOT00065009168
resolver
genesymbol
Spred2
resolver
uniprot
A0ABK0LCU8
resolver
uniprot_entry
A0ABK0LCU8_RAT
resolver
uniprot_entry
SPRE2_RAT
resolver
amino_acid_sequence
MTEETHPDDDSYIVRVKAVVMTRDDSSGGWFPQEGGGISRVGVCKVMHPEGNGRSGFLIHGERQKDKLVVLECYVRKDLVYTKANPTFHHWKVDNRKFGLTFQSPADARAFDRGVRKAIEDLIEGSTTSSSTIHNEAELGDDDVFTTATDSSSNSSQKREPNTRTISSPTSCEHRRIYTLDPYPMDLYHPDQRLPRSYPQVTFPEDDEEIVRINPREKIWMTGYEDYRHAPVRGKYLDSTEDADSYVRFAKGEVPKHEYTYPYVDSSDFGFGEDPKGNVIKTQPPRAKSRRRKENGERSRCVYCRDMFNHEENRRGHCQDAPDAVRTCIRRVSCMWCADSMLYHCMSDPEGDYTDPCSCDTSDEKFCLRWMALIALSFLAPCMCCYLPLRACHHCGVMCRCCGGKHKAAA
uniprot
proteins
function
FUNCTION: Negatively regulates Ras signaling pathways and downstream activation of MAP kinases. Recruits and translocates NF1 to the cell membrane, thereby enabling NF1-dependent hydrolysis of active GTP-bound Ras to inactive GDP-bound Ras (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q7Z698, ECO:0000250|UniProtKB:Q924S7}.
uniprot
proteins
mass_dalton
46805
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine and threonine residues. Phosphorylated on tyrosine. Phosphorylation of Tyr-224 and Tyr-227 are required for ubiquitination. {ECO:0000250|UniProtKB:Q7Z698}.; PTM: Ubiquitinated; leading to degradation by the proteasome. {ECO:0000250|UniProtKB:Q7Z698}.
uniprot
proteins
pubmed
17974561
uniprot
proteins
pubmed
25576668
uniprot
proteins
sequence_length
410
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q924S7}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q924S7}; Cytoplasmic side {ECO:0000250|UniProtKB:Q924S7}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:Q7Z698}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q7Z698}; Cytoplasmic side {ECO:0000250|UniProtKB:Q7Z698}. Cytoplasm {ECO:0000250|UniProtKB:Q7Z698}. Note=Detected in the cytoplasm of the stratum spinosum cells, where it is associated with cytoplasmic vesicles that are supposed to be secretory granules. {ECO:0000250|UniProtKB:Q7Z698}.
uniprot
proteins