KLK8
entrez
11202
canonical
uniprot
O60259
canonical
ensembl
ENSG00000129455
resolver
ensp
ENSP00000291726
resolver
ensp
ENSP00000325072
resolver
ensp
ENSP00000341555
resolver
ensp
ENSP00000375682
resolver
ensp
ENSP00000512260
resolver
enst
ENST00000291726
resolver
genesymbol
KLK8
resolver
genesymbol_syn
NRPN
resolver
genesymbol_syn
PRSS19
resolver
genesymbol_syn
TADG14
resolver
hgnc
HGNC:6369
resolver
uniprot
A0A0A0MQY9
resolver
uniprot
Q5V9X1
resolver
uniprot
Q5V9X2
resolver
uniprot
Q8IW69
resolver
uniprot
Q9HCB3
resolver
uniprot
Q9NR68
resolver
uniprot
Q9NR69
resolver
uniprot
Q9UIL9
resolver
uniprot
Q9UQ47
resolver
uniprot_entry
A0A0A0MQY9_HUMAN
resolver
uniprot_entry
KLK8_HUMAN
resolver
uniprot_sec
Q5V9X1
resolver
uniprot_sec
Q5V9X2
resolver
uniprot_sec
Q8IW69
resolver
uniprot_sec
Q9HCB3
resolver
uniprot_sec
Q9NR68
resolver
uniprot_sec
Q9NR69
resolver
uniprot_sec
Q9UIL9
resolver
uniprot_sec
Q9UQ47
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by a range of serine protease inhibitors including antipain, aprotinin, leupeptin, benzamidine and soybean trypsin inhibitor. {ECO:0000269|PubMed:16337200}.
uniprot
proteins
amino_acid_sequence
MGRPRPRAAKTWMFLLLLGGAWAGHSRAQEDKVLGGHECQPHSQPWQAALFQGQQLLCGGVLVGGNWVLTAAHCKKPKYTVRLGDHSLQNKDGPEQEIPVVQSIPHPCYNSSDVEDHNHDLMLLQLRDQASLGSKVKPISLADHCTQPGQKCTVSGWGTVTSPRENFPDTLNCAEVKIFPQKKCEDAYPGQITDGMVCAGSSKGADTCQGDSGGPLVCDGALQGITSWGSDPCGRSDKPGVYTNICRYLDWIKKIIGSKG
uniprot
proteins
ec_number
3.4.21.118
uniprot
proteins
function
FUNCTION: Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury. {ECO:0000269|PubMed:16337200}.
uniprot
proteins
mass_dalton
28048
uniprot
proteins
protein_family
Kallikrein subfamily
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
10102990
uniprot
proteins
pubmed
10485494
uniprot
proteins
pubmed
11054574
uniprot
proteins
pubmed
11309326
uniprot
proteins
pubmed
11522960
uniprot
proteins
pubmed
12147714
uniprot
proteins
pubmed
12782581
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15282331
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16337200
uniprot
proteins
pubmed
17487847
uniprot
proteins
pubmed
17761692
uniprot
proteins
pubmed
19194479
uniprot
proteins
pubmed
9714609
uniprot
proteins
sequence_length
260
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17761692}. Cytoplasm {ECO:0000269|PubMed:17761692}. Note=Shows a cytoplasmic distribution in the keratinocytes.
uniprot
proteins