P20266
uniprot
P20266
canonical
amino_acid_sequence
MMSMNSKQPHFAMHPTLPEHKYPSLHSSSEAIRRACLPTPPLQSNLFASLDETLLARAEALAAVDIAVSQGKSHPFKPDATYHTMNSVPCTSTSTVPLAHHHHHHHHHQALEPGDLLDHISSPSLALMAGAGGAGAAGGGGAPTRPRGAGGPGGGGGPGGGGPGVAGRRRGPGGGGGGPGGGLLGXSAHPHPHMHGXGHLSHPAAAAAMNMPSGLPHPGLVAAAAHHGAAAAAAAAAAGQVAAASAAAAVVGAAGLASICDSDTDPRELEAFAERFKQRRIKLGVTQADVGSALANLKIPGVGSLSQSTICRFESLTLSHNNMIALKPILQAWLEEAEGAQREKMNKPELFNGGEKKRKRTSIAAPEKRSLEAYFAVQPRPSSEKIAAIAEKLDLKKNVVRVWFCNQRQKQKRMKFSATY
uniprot
proteins
function
FUNCTION: Multifunctional transcription factor with different regions mediating its different effects (PubMed:10640682). Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages (PubMed:11053412). It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor. Activates BCL2 expression and protects neuronal cells from apoptosis (via the N-terminal domain). Induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins. Exerts its major developmental effects in somatosensory neurons and in brainstem nuclei involved in motor control. Stimulates the binding affinity of the nuclear estrogene receptor ESR1 to DNA estrogen response element (ERE), and hence modulates ESR1-induced transcriptional activity. May positively regulate POU4F2 and POU4F3. Regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Plays a role in TNFSF11-mediated terminal osteoclast differentiation. Negatively regulates its own expression interacting directly with a highly conserved autoregulatory domain surrounding the transcription initiation site (By similarity). {ECO:0000250|UniProtKB:P17208, ECO:0000269|PubMed:10640682, ECO:0000269|PubMed:11053412}.; FUNCTION: [Isoform 2]: Able to act as a transcription factor, cannot regulate the expression of the same subset of genes as isoform 1. Does not have an antiapoptotic effect on neuronal cells. {ECO:0000250|UniProtKB:P17208}.
uniprot
proteins
mass_dalton
43275
uniprot
proteins
protein_family
Class-4 subfamily
uniprot
proteins
protein_family
POU transcription factor family
uniprot
proteins
pubmed
10640682
uniprot
proteins
pubmed
11053412
uniprot
proteins
pubmed
1383937
uniprot
proteins
pubmed
2739723
uniprot
proteins
pubmed
8835784
uniprot
proteins
sequence_length
420
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P17208}. Cytoplasm {ECO:0000250|UniProtKB:P17208}.
uniprot
proteins