OSBPL1A
entrez
114876
canonical
uniprot
Q9BXW6
canonical
ensembl
ENSG00000141447
resolver
ensp
ENSP00000320291
resolver
ensp
ENSP00000349545
resolver
ensp
ENSP00000382372
resolver
genesymbol
OSBPL1A
resolver
genesymbol_syn
ORP1
resolver
genesymbol_syn
OSBP8
resolver
genesymbol_syn
OSBPL1
resolver
genesymbol_syn
OSBPL1B
resolver
hgnc
HGNC:16398
resolver
uniprot
B0YJ56
resolver
uniprot
B3KU11
resolver
uniprot
B7Z7D3
resolver
uniprot
Q6GSK5
resolver
uniprot
Q9BZF5
resolver
uniprot
Q9NW87
resolver
uniprot_entry
B0YJ56_HUMAN
resolver
uniprot_entry
B3KU11_HUMAN
resolver
uniprot_entry
OSBL1_HUMAN
resolver
uniprot_entry
Q6GSK5_HUMAN
resolver
uniprot_sec
B7Z7D3
resolver
uniprot_sec
Q9BZF5
resolver
uniprot_sec
Q9NW87
resolver
amino_acid_sequence
MNTEAEQQLLHHARNGNAEEVRQLLETMARNEVIADINCKGRSKSNLGWTPLHLACYFGHRQVVQDLLKAGAEVNVLNDMGDTPLHRAAFTGRKELVMLLLEYNADTTIVNGSGQTAKEVTHAEEIRSMLEAVERTQQRKLEELLLAAAREGKTTELTALLNRPNPPDVNCSDQLGNTPLHCAAYRAHKQCALKLLRSGADPNLKNKNDQKPLDLAQGAEMKHILVGNKVIYKALKRYEGPLWKSSRFFGWRLFWVVLEHGVLSWYRKQPDAVHNIYRQGCKHLTQAVCTVKSTDSCLFFIKCFDDTIHGFRVPKNSLQQSREDWLEAIEEHSAYSTHYCSQDQLTDEEEEDTVSAADLKKSLEKAQSCQQRLDREISNFLKMIKECDMAKEMLPSFLQKVEVVSEASRETCVALTDCLNLFTKQEGVRNFKLEQEQEKNKILSEALETLATEHHELEQSLVKGSPPASILSEDEFYDALSDSESERSLSRLEAVTARSFEEEGEHLGSRKHRMSEEKDCGGGDALSNGIKKHRTSLPSPMFSRNDFSIWSILRKCIGMELSKITMPVIFNEPLSFLQRLTEYMEHTYLIHKASSLSDPVERMQCVAAFAVSAVASQWERTGKPFNPLLGETYELVRDDLGFRLISEQVSHHPPISAFHAEGLNNDFIFHGSIYPKLKFWGKSVEAEPKGTITLELLEHNEAYTWTNPTCCVHNIIVGKLWIEQYGNVEIINHKTGDKCVLNFKPCGLFGKELHKVEGYIQDKSKKKLCALYGKWTECLYSVDPATFDAYKKNDKKNTEEKKNSKQMSTSEELDEMPVPDSESVFIIPGSVLLWRIAPRPPNSAQMYNFTSFAMVLNEVDKDMESVIPKTDCRLRPDIRAMENGEIDQASEEKKRLEEKQRAARKNRSKSEEDWKTRWFHQGPNPYNGAQDWIYSGSYWDRNYFNLPDIY
uniprot
proteins
function
FUNCTION: Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (By similarity). Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A (PubMed:16176980). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000250, ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:17428193}.
uniprot
proteins
mass_dalton
108470
uniprot
proteins
mutagenesis
MUTAGEN 476..477; /note="FY->AA: Loss of interaction with MOSPD2."; /evidence="ECO:0000269|PubMed:29858488
uniprot
proteins
protein_family
OSBP family
uniprot
proteins
pubmed
11279184
uniprot
proteins
pubmed
11483621
uniprot
proteins
pubmed
11735225
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16176980
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17428193
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
29858488
uniprot
proteins
pubmed
33124732
uniprot
proteins
sequence_length
950
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome {ECO:0000269|PubMed:16176980, ECO:0000269|PubMed:29858488}. Note=Colocalizes with RAB7A, RAB9A and LAMP1 in late endosomes.
uniprot
proteins