Cfdp1
entrez
23837
canonical
uniprot
O88271
canonical
ensembl
ENSMUSG00000031954
resolver
ensp
ENSMUSP00000034432
resolver
ensp
ENSMUSP00000200642
resolver
enst
ENSMUST00000034432
resolver
genesymbol
Cfdp1
resolver
genesymbol_syn
Bcnt
resolver
genesymbol_syn
Cfdp
resolver
genesymbol_syn
Cp27
resolver
uniprot
O70565
resolver
uniprot
Q9JMA5
resolver
uniprot_entry
CFDP1_MOUSE
resolver
uniprot_sec
O70565
resolver
uniprot_sec
Q9JMA5
resolver
amino_acid_sequence
MEEFDSEDFSTSDEDEDYLPSGGEYSEDDVNELVKEDEVDGEEQAEKTKGKRRKAQGIPARKRKQSGLLLEEEEDGKEDSGGSSSEEDEEEQEGGLGSENARKKKEDELWASFLNDVGPKSKAAPGSQTKVAEETEEISSNKPLVKADELDKPRESEKVKITKVFDFAGEEVRVTKEVDAASKEAKSFLKQTEREKPQALVTSPATPLPAGSGIKRASGMSSLLGKIGAKKQKMSTLEKSKLDWESFKEEEGIGEELAIHNRGKEGYIERKAFLDRVDHRQFEIERDLRLSKMKP
uniprot
proteins
function
FUNCTION: Required for the structural stability of pericentromeric heterochromatin (PubMed:38630655). Regulates heterochromatin state by stabilizing CBX5/HP1alpha and H3K9me3 at major satellites and CENPA at minor satellites, and is required for incorporation of histone H2AZ1/H2AZ into chromatin (PubMed:38630655). Maintenance of chromatin structure promotes binding of guanine-nucleotide releasing factor RCC1 to minor and major satellite repeats (PubMed:38630655). Chromatin-bound RCC1 maintains high levels of GTP-bound RAN near the centromeric heterochromatin, facilitating RAN-mediated microtubule nucleation during mitosis (PubMed:38630655). Plays a role in craniofacial development (PubMed:11992732, PubMed:38630655). Required to maintain normal cell function in embryonic development (PubMed:12153613). {ECO:0000269|PubMed:11992732, ECO:0000269|PubMed:12153613, ECO:0000269|PubMed:38630655}.
uniprot
proteins
mass_dalton
32921
uniprot
proteins
protein_family
SWC5/CFDP1/CFDP2 family
uniprot
proteins
pubmed
10415329
uniprot
proteins
pubmed
11368901
uniprot
proteins
pubmed
11992732
uniprot
proteins
pubmed
12153613
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
38630655
uniprot
proteins
pubmed
9602175
uniprot
proteins
sequence_length
295
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q9UEE9}. Nucleus {ECO:0000269|PubMed:38630655}. Chromosome {ECO:0000269|PubMed:38630655}. Note=Colocalizes with heterochromatin at major and minor satellites. {ECO:0000269|PubMed:38630655}.
uniprot
proteins