EZHIP
entrez
340602
canonical
uniprot
Q86X51
canonical
ensembl
ENSG00000187690
resolver
ensp
ENSP00000342680
resolver
enst
ENST00000342995
resolver
genesymbol
EZHIP
resolver
genesymbol
KIP75
resolver
genesymbol_syn
CXorf67
resolver
hgnc
HGNC:33738
resolver
uniprot
A0A515VFR0
resolver
uniprot_entry
A0A515VFR0_HUMAN
resolver
uniprot_entry
EZHIP_HUMAN
resolver
amino_acid_sequence
MATQSDMEKEQKHQQDEGQGGLNNETALASGDACGTGNQDPAASVTTVSSQASPSGGAALSSSTAGSSAAAATSAAIFITDEASGLPIIAAVLTERHSDRQDCRSPHEVFGCVVPEGGSQAAVGPQKATGHADEHLAQTKSPGNSRRRKQPCRNQAAPAQKPPGRRLFPEPLPPSSPGFRPSSYPCSGASTSSQATQPGPALLSHASEARPATRSRITLVASALRRRASGPGPVIRGCTAQPGPAFPHRATHLDPARLSPESAPGPARRGRASVPGPARRGCDSAPGPARRGRDSAPVSAPRGRDSAPGSARRGRDSAPGPALRVRTARSDAGHRSTSTTPGTGLRSRSTQQRSALLSRRSLSGSADENPSCGTGSERLAFQSRSGSPDPEVPSRASPPVWHAVRMRASSPSPPGRFFLPIPQQWDESSSSSYASNSSSPSRSPGLSPSSPSPEFLGLRSISTPSPESLRYALMPEFYALSPVPPEEQAEIESTAHPATPPEP
uniprot
proteins
function
FUNCTION: Inhibits PRC2/EED-EZH1 and PRC2/EED-EZH2 complex function by inhibiting EZH1/EZH2 methyltransferase activity, thereby causing down-regulation of histone H3 trimethylation on 'Lys-27' (H3K27me3) (PubMed:29909548, PubMed:30923826, PubMed:31086175, PubMed:31451685). Probably inhibits methyltransferase activity by limiting the stimulatory effect of cofactors such as AEBP2 and JARID2 (PubMed:30923826). Inhibits H3K27me3 deposition during spermatogenesis and oogenesis (By similarity). {ECO:0000250|UniProtKB:B1B0V2, ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175, ECO:0000269|PubMed:31451685}.
uniprot
proteins
mass_dalton
51894
uniprot
proteins
mutagenesis
MUTAGEN 73; /note="T->S: Decreases inhibition of H3K27me3."; /evidence="ECO:0000269|PubMed:29909548"; MUTAGEN 81; /note="D->Y: No effect on H3K27me3 levels."; /evidence="ECO:0000269|PubMed:31086175"; MUTAGEN 88; /note="I->F: Slightly decreases inhibition of H3K27me3."; /evidence="ECO:0000269|PubMed:29909548"; MUTAGEN 184; /note="Y->C: Decreases inhibition of H3K27me3."; /evidence="ECO:0000269|PubMed:29909548"; MUTAGEN 394..417; /note="Missing: Abolishes interaction with the PRC2 complex and causes increased H3K27me3 levels."; /evidence="ECO:0000269|PubMed:31451685"; MUTAGEN 405; /note="R->E: Does not inhibit PRC2/EED-EZH2 complex activity and abolishes ability to decrease H3K27me3 levels."; /evidence="ECO:0000269|PubMed:31086175"; MUTAGEN 406; /note="M->A: Does not act as a substrate of the PRC2/EED-EZH2 complex."; /evidence="ECO:0000269|PubMed:31086175"; MUTAGEN 406; /note="M->E,R: Does not reduce H3K27me3 levels."; /evidence="ECO:0000269|PubMed:31086175"; MUTAGEN 406; /note="M->I: Does not affect inhibition of H3K27me3 levels."; /evidence="ECO:0000269|PubMed:31086175"; MUTAGEN 406; /note="M->K: Acts as a substrate of the PRC2/EED-EZH2 complex and does not reduce H3K27me3 levels."; /evidence="ECO:0000269|PubMed:31086175"; MUTAGEN 407; /note="R->E: No effect on H3K27me3 levels."; /evidence="ECO:0000269|PubMed:31086175
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
29909548
uniprot
proteins
pubmed
30923826
uniprot
proteins
pubmed
31086175
uniprot
proteins
pubmed
31451685
uniprot
proteins
sequence_length
503
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29909548, ECO:0000269|PubMed:30923826, ECO:0000269|PubMed:31086175}. Cytoplasm {ECO:0000269|PubMed:30923826}.
uniprot
proteins