PRKAG2
entrez
51422
canonical
uniprot
Q9UGJ0
canonical
ensembl
ENSG00000106617
resolver
ensp
ENSP00000287878
resolver
ensp
ENSP00000376549
resolver
ensp
ENSP00000387386
resolver
ensp
ENSP00000419493
resolver
ensp
ENSP00000419577
resolver
ensp
ENSP00000498384
resolver
ensp
ENSP00000498796
resolver
ensp
ENSP00000498886
resolver
ensp
ENSP00000499111
resolver
ensp
ENSP00000671642
resolver
enst
ENST00000492843
resolver
enst
ENST00000650858
resolver
enst
ENST00000652047
resolver
enst
ENST00000652321
resolver
genesymbol
PRKAG2
resolver
hgnc
HGNC:9386
resolver
uniprot
A0A384MDZ2
resolver
uniprot
A0A494C068
resolver
uniprot
A0A494C155
resolver
uniprot
A0A494C1K7
resolver
uniprot
B7Z6X8
resolver
uniprot
E9PGP6
resolver
uniprot
Q53Y07
resolver
uniprot
Q6NUI0
resolver
uniprot
Q75MP4
resolver
uniprot
Q9NUZ9
resolver
uniprot
Q9UDN8
resolver
uniprot
Q9ULX8
resolver
uniprot_entry
A0A384MDZ2_HUMAN
resolver
uniprot_entry
A0A494C068_HUMAN
resolver
uniprot_entry
A0A494C155_HUMAN
resolver
uniprot_entry
A0A494C1K7_HUMAN
resolver
uniprot_entry
AAKG2_HUMAN
resolver
uniprot_entry
B7Z6X8_HUMAN
resolver
uniprot_entry
E9PGP6_HUMAN
resolver
uniprot_sec
Q53Y07
resolver
uniprot_sec
Q6NUI0
resolver
uniprot_sec
Q75MP4
resolver
uniprot_sec
Q9NUZ9
resolver
uniprot_sec
Q9UDN8
resolver
uniprot_sec
Q9ULX8
resolver
amino_acid_sequence
MGSAVMDTKKKKDVSSPGGSGGKKNASQKRRSLRVHIPDLSSFAMPLLDGDLEGSGKHSSRKVDSPFGPGSPSKGFFSRGPQPRPSSPMSAPVRPKTSPGSPKTVFPFSYQESPPRSPRRMSFSGIFRSSSKESSPNSNPATSPGGIRFFSRSRKTSGLSSSPSTPTQVTKQHTFPLESYKHEPERLENRIYASSSPPDTGQRFCPSSFQSPTRPPLASPTHYAPSKAAALAAALGPAEAGMLEKLEFEDEAVEDSESGVYMRFMRSHKCYDIVPTSSKLVVFDTTLQVKKAFFALVANGVRAAPLWESKKQSFVGMLTITDFINILHRYYKSPMVQIYELEEHKIETWRELYLQETFKPLVNISPDASLFDAVYSLIKNKIHRLPVIDPISGNALYILTHKRILKFLQLFMSDMPKPAFMKQNLDELGIGTYHNIAFIHPDTPIIKALNIFVERRISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFEGVVKCNKLEILETIVDRIVRAEVHRLVVVNEADSIVGIISLSDILQALILTPAGAKQKETETE
uniprot
proteins
disease_involvement
DISEASE: Wolff-Parkinson-White syndrome (WPW) [MIM:194200]: A supernormal conduction disorder characterized by the presence of one or several accessory atrioventricular connections, which can lead to episodes of sporadic tachycardia. {ECO:0000269|PubMed:11407343, ECO:0000269|PubMed:11748095, ECO:0000269|PubMed:14722619}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Cardiomyopathy, familial hypertrophic, 6 (CMH6) [MIM:600858]: A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. CMH6 patients present Wolff-Parkinson-White ventricular preexcitation, enlarged myocytes without myofiber disarray, and glycogen-containing cytosolic vacuoles within cardiomyocytes. {ECO:0000269|PubMed:11371514, ECO:0000269|PubMed:11827995}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Glycogen storage disease of heart lethal congenital (GSDH) [MIM:261740]: Rare disease which leads to death within a few weeks to a few months after birth, through heart failure and respiratory compromise. {ECO:0000269|PubMed:15877279}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:14722619, PubMed:24563466). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:14722619, PubMed:24563466). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:14722619, PubMed:24563466). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:14722619, PubMed:24563466). Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits (PubMed:14722619, PubMed:24563466). ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit (PubMed:14722619, PubMed:24563466). ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (PubMed:14722619, PubMed:24563466). {ECO:0000269|PubMed:14722619, ECO:0000269|PubMed:24563466}.
uniprot
proteins
mass_dalton
63066
uniprot
proteins
mutagenesis
MUTAGEN 387; /note="V->S: Induces phosphorylation by AMPK."; /evidence="ECO:0000269|PubMed:17255938
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK. {ECO:0000269|PubMed:21460634}.; PTM: Glycosylated; O-GlcNAcylated by OGT, promoting the AMP-activated protein kinase (AMPK) activity. {ECO:0000269|PubMed:24563466}.
uniprot
proteins
protein_family
5'-AMP-activated protein kinase gamma subunit family
uniprot
proteins
pubmed
10698692
uniprot
proteins
pubmed
11112354
uniprot
proteins
pubmed
11371514
uniprot
proteins
pubmed
11407343
uniprot
proteins
pubmed
11748095
uniprot
proteins
pubmed
11827995
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14722619
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15877279
uniprot
proteins
pubmed
17255938
uniprot
proteins
pubmed
17307971
uniprot
proteins
pubmed
17712357
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21460634
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24563466
uniprot
proteins
pubmed
38424693
uniprot
proteins
sequence_length
569
uniprot
proteins