Gpr37
entrez
117549
canonical
uniprot
Q9QYC6
canonical
ensembl
ENSRNOG00000002524
resolver
ensembl
ENSRNOG00055021199
resolver
ensembl
ENSRNOG00060018313
resolver
ensembl
ENSRNOG00065024650
resolver
ensp
ENSRNOP00000003593
resolver
ensp
ENSRNOP00055029422
resolver
ensp
ENSRNOP00060025506
resolver
ensp
ENSRNOP00065034633
resolver
enst
ENSRNOT00000003593
resolver
enst
ENSRNOT00055036212
resolver
enst
ENSRNOT00060031435
resolver
enst
ENSRNOT00065042331
resolver
genesymbol
Gpr37
resolver
uniprot_entry
GPR37_RAT
resolver
amino_acid_sequence
MPAPGAPLSRTSRLLLLLLFKVSVSAALSFVPEPRNGTCLGESCSPLIPRRSRDAGGPRNSARDALRVHVPREKLEAEVRGATSWDLPPPRGGDTGVIEEAAASGPLGPPTKPPGAWRWKGAQGKEPSGHLGRREPTDSQLFRQTSERGEMSSKRDEIPQGSQEHSVKTEPEPRDLFYWPRKTGQLQGSHYRPSAVHEGRTLAPPGRALPQNGSADDWVPDQGGPRRGNSTNRRVRLKNPFYPLTQESYGAYAVMCLSVVIFGTGIIGNLAVMCIVCHNYYMRSISNSLLANLAFWDFLIIFFCLPLVIFHELTKKWLLEDFSCKIVPYIEVASLGVTTFTLCALCIDRFRAATNVQMYYEMIENCSSTTAKLAVIWVGALLLALPEVVLRQLSKEDLGFSGQAPAERCVIKISPDLPDTIYVLALTYDGARLWWYFGCYFCLPTLFTITCSLVTARKIRKAEKASTRGNKRQIHLESQMNCTVVALTILYGFCIIPENICNIVTAYMATGVSQQTMDLLNIISQFLLFFKSCVTPVLLFCLCRPFSRAFMECCCCCCEECIQKSSTVTSDDNDNEYTTELELSPFSTIRREMSTFASVGTHC
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that plays a role in several physiological pathways such as resolution of inflammatory pain and oligodendrocyte differentiation (By similarity). Acts as a receptor for several ligands including prosaposin, osteocalcin or neuroprotectin D1. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade (By similarity). Acts as a receptor for osteocalcin (OCN) to regulate oligodendrocyte differentiation and central nervous system myelination. Mechanistically, plays a negative role in oligodendrocyte differentiation and myelination during development via activation of the ERK1/2 signaling pathway. Therefore, regulates the stability of myelin or resistance of myelin itself to demyelination. Upon activation by neuroprotectin D1 (NPD1), promotes the activation of phagocytosis in macrophages as well as the shift in cytokine release toward an anti-inflammatory profile, and thus helps to reverse inflammatory pain. In addition, the increased macrophage phagocytosis mediates protection against sepsis upon pathogen infection. Additionally, extracellular vesicles derived from efferocyte express prosaposin, which binds to macrophage GPR37 to increase expression of the efferocytosis receptor TIM4 via an ERK-AP1-dependent signaling axis, leading to increased macrophage efferocytosis efficiency and accelerated resolution of inflammation (By similarity). May also act as a maturation factor of LRP6, protecting LRP6 from the endoplasmic reticulum (ER)-associated protein degradation (ERAD) and thereby promoting the Wnt/beta-catenin signaling pathway (By similarity). {ECO:0000250|UniProtKB:O15354, ECO:0000250|UniProtKB:Q9QY42}.
uniprot
proteins
mass_dalton
66961
uniprot
proteins
post_translational_modification
PTM: The N-terminus is cleaved by ADAM10 metalloproteinase; mediating limited proteolysis leading to the release of receptor ectodomain by shedding. In addition, cleaved by FURIN between Arg-53 and Asp-54. {ECO:0000250|UniProtKB:O15354}.; PTM: Ubiquitinated by PRKN in the presence of UBE2E1 and UBE2L3 in the endoplasmic reticulum. The unfolded form is specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation and prevents neuronal cell death. {ECO:0000250|UniProtKB:O15354}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10350639
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
603
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, dendrite {ECO:0000250|UniProtKB:O15354}. Synapse {ECO:0000250|UniProtKB:O15354}. Cell membrane {ECO:0000250|UniProtKB:O15354}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O15354}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O15354}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O15354}.
uniprot
proteins
transmembrane_region
TRANSMEM 256..276; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 290..310; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 326..346; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 370..390; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 434..454; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 484..504; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 522..542; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins