Cep55
entrez
74107
canonical
uniprot
Q8BT07
canonical
ensembl
ENSMUSG00000024989
resolver
ensp
ENSMUSP00000093802
resolver
ensp
ENSMUSP00000127961
resolver
ensp
ENSMUSP00000157871
resolver
ensp
ENSMUSP00000157898
resolver
ensp
ENSMUSP00000164407
resolver
ensp
ENSMUSP00000164408
resolver
ensp
ENSMUSP00000164409
resolver
ensp
ENSMUSP00000164412
resolver
ensp
ENSMUSP00000164413
resolver
ensp
ENSMUSP00000164414
resolver
ensp
ENSMUSP00000164415
resolver
ensp
ENSMUSP00000358070
resolver
genesymbol
Cep55
resolver
uniprot
Q8C2J0
resolver
uniprot
Q8K2I8
resolver
uniprot
Q8R2Y4
resolver
uniprot
Q9DBZ8
resolver
uniprot_entry
CEP55_MOUSE
resolver
uniprot_sec
Q8C2J0
resolver
uniprot_sec
Q8K2I8
resolver
uniprot_sec
Q8R2Y4
resolver
uniprot_sec
Q9DBZ8
resolver
amino_acid_sequence
MSSRSPKDLIKSKWGSRPSSSKSDTALEKFKGEIAAFKTSLDEITSGKGKMAEKGRSRLLEKIQVLEAEREKNVYYLLEKDKEIQRLKDHLRSRYSSSSLFEQLEEKTKECEKKQQLLESLSKETDVLKNQLSATTKRLSELESKASTLHLSQSMPANCFNSSMNSIHEKEMQLKDALEKNQQWLVYDQQREAYVKGLLAKIFELEKRTETAAASLTQQMKKIESEGYLQVEKQKYDHLLENAKKDLEVERQAVTQLRLELDEFRRKYEEARKEVEDLNQLLSSQRKADIQHLEEDKQKTERIQKLREESSIFKGKLEEERKRSEELLSQVRILYDSLLKHQEEQARVALLEQQMQACTLDFENEKLDRQNMQHQLYVILKELRKAKSQITQLESLKQLHGFTITEQPFPLQREPESRVKATSPKSPSAALNDSLVECPKCSVQYPATEHRDLLVHVEYCMK
uniprot
proteins
function
FUNCTION: Plays a role in mitotic exit and cytokinesis. Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis. Not required for microtubule nucleation. Plays a role in the development of the brain and kidney. {ECO:0000250|UniProtKB:Q53EZ4}.
uniprot
proteins
mass_dalton
53930
uniprot
proteins
post_translational_modification
PTM: There is a hierachy of phosphorylation, where both Ser-423 and Ser-426 are phosphorylated at the onset of mitosis, prior to Ser-434. Phosphorylation at Ser-423 and Ser-426 is required for dissociation from the centrosome at the G2/M boundary. Phosphorylation at the 3 sites, Ser-423, Ser-426 and Ser-434, is required for protein function at the final stages of cell division to complete cytokinesis successfully (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
462
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q53EZ4}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q53EZ4}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q53EZ4}. Cleavage furrow {ECO:0000250|UniProtKB:Q53EZ4}. Midbody, Midbody ring {ECO:0000250|UniProtKB:Q53EZ4}. Midbody {ECO:0000250|UniProtKB:Q53EZ4}. Note=Present at the centrosomes at interphase. A small portion is associated preferentially with the mother centriole, whereas the majority localizes to the pericentriolar material. During mitosis, loses affinity for the centrosome at the onset of prophase and diffuses throughout the cell. This dissociation from the centrosome is phosphorylation-dependent. May remain localized at the centrosome during mitosis in certain cell types. Appears at the cleavage furrow in late anaphase and in the midbody in cytokinesis. {ECO:0000250|UniProtKB:Q53EZ4}.
uniprot
proteins