Clcn3
entrez
12725
canonical
uniprot
P51791
canonical
ensembl
ENSMUSG00000004319
resolver
ensp
ENSMUSP00000004430
resolver
ensp
ENSMUSP00000058648
resolver
ensp
ENSMUSP00000091202
resolver
ensp
ENSMUSP00000105930
resolver
ensp
ENSMUSP00000105931
resolver
ensp
ENSMUSP00000301423
resolver
ensp
ENSMUSP00000301448
resolver
ensp
ENSMUSP00000301450
resolver
enst
ENSMUST00000056508
resolver
enst
ENSMUST00000093490
resolver
enst
ENSMUST00000110301
resolver
enst
ENSMUST00000110302
resolver
genesymbol
Clcn3
resolver
genesymbol_syn
Clc3
resolver
uniprot
A0A6Q6Q7B9
resolver
uniprot
E9Q2I1
resolver
uniprot
Q3TF45
resolver
uniprot
Q790S0
resolver
uniprot
Q8K4W8
resolver
uniprot
Q8K4X0
resolver
uniprot
Q8K4X1
resolver
uniprot_entry
A0A6Q6Q7B9_MOUSE
resolver
uniprot_entry
CLCN3_MOUSE
resolver
uniprot_entry
E9Q2I1_MOUSE
resolver
uniprot_entry
Q790S0_MOUSE
resolver
uniprot_entry
Q8K4W8_MOUSE
resolver
uniprot_sec
Q3TF45
resolver
uniprot_sec
Q8K4X0
resolver
uniprot_sec
Q8K4X1
resolver
activity_regulation
ACTIVITY REGULATION: [Isoform 2]: Inhibited by Cd(2+). {ECO:0000269|PubMed:24603049}.; ACTIVITY REGULATION: [Isoform 5]: Inhibited by Cd(2+). {ECO:0000269|PubMed:24603049}.
uniprot
proteins
amino_acid_sequence
MESEQLFHRGYYRNSYNSITSASSDEELLDGAGAIMDFQTSEDDNLLDGDTAAGTHYTMTNGGSINSSTHLLDLLDEPIPGVGTYDDFHTIDWVREKCKDRERHRRINSKKKESAWEMTKSLYDAWSGWLVVTLTGLASGALAGLIDIAADWMTDLKEGICLSALWYNHEQCCWGSNETTFEERDKCPQWKTWAELIIGQAEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIKTITLVLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYSTNEAKKREVLSAASAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGNSRLVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGKYPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKIVDDIPDRPAGVGVYSAIWQLCLALIFKIIMTVFTFGIKVPSGLFIPSMAIGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVGADCITPGLYAMVGAAACLGGVTRMTVSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLDAKEEFTHTTLAADVMRPRRSDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFALRRDLTIAIESARKKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSILDMSPFTVTDHTPMEIVVDIFRKLGLRQCLVTHNGIVLGIITKKDILRHMAQTANQDPASIMFN
uniprot
proteins
function
FUNCTION: May influence large dense-core vesicle exocytosis in adrenal chromaffin cells. {ECO:0000269|PubMed:16141072}.; FUNCTION: [Isoform 1]: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (PubMed:26342074). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). {ECO:0000250|UniProtKB:P51790, ECO:0000269|PubMed:26342074}.; FUNCTION: [Isoform 2]: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (PubMed:24603049, PubMed:26342074, PubMed:28972156). Facilitates endosomal acidification and chloride accumulation in hepatocytes (PubMed:15504734). {ECO:0000269|PubMed:15504734, ECO:0000269|PubMed:24603049, ECO:0000269|PubMed:26342074, ECO:0000269|PubMed:28972156}.; FUNCTION: [Isoform 4]: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. {ECO:0000269|PubMed:26342074}.
uniprot
proteins
mass_dalton
90812
uniprot
proteins
mutagenesis
MUTAGEN P51791-5:224; /note="E->A: Abolishes outwardly-rectifying currents."; /evidence="ECO:0000269|PubMed:24603049
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:P51790}.
uniprot
proteins
protein_family
Chloride channel (TC 2.A.49) family
uniprot
proteins
protein_family
ClC-3/CLCN3 subfamily
uniprot
proteins
pubmed
15504734
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16222710
uniprot
proteins
pubmed
18923035
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
24603049
uniprot
proteins
pubmed
26342074
uniprot
proteins
pubmed
28972156
uniprot
proteins
pubmed
7665160
uniprot
proteins
pubmed
9678416
uniprot
proteins
sequence_length
818
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:18923035}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 1]: Lysosome membrane {ECO:0000269|PubMed:26342074, ECO:0000269|PubMed:28972156}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:28972156}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:P51792}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:P51790}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 2]: Early endosome membrane {ECO:0000269|PubMed:16222710}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:26342074, ECO:0000269|PubMed:28972156}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:16222710, ECO:0000269|PubMed:28972156}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000269|PubMed:26342074}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000269|PubMed:26342074, ECO:0000269|PubMed:28972156}; Multi-pass membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 5]: Cell membrane {ECO:0000269|PubMed:24603049}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 126..163; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 209..232; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 258..276; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 282..301; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 349..367; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 391..416; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 423..443; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 500..520; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 525..544; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 606..624; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523
uniprot
proteins