Msrb1
entrez
685059
canonical
uniprot
Q52KJ8
canonical
ensembl
ENSRNOG00000055314
resolver
ensembl
ENSRNOG00055028205
resolver
ensembl
ENSRNOG00060010653
resolver
ensembl
ENSRNOG00065009290
resolver
ensp
ENSRNOP00000074809
resolver
ensp
ENSRNOP00055040103
resolver
ensp
ENSRNOP00060014058
resolver
ensp
ENSRNOP00065011097
resolver
enst
ENSRNOT00055048792
resolver
enst
ENSRNOT00060018053
resolver
enst
ENSRNOT00065014845
resolver
genesymbol
Msrb1
resolver
genesymbol_syn
Sepx1
resolver
uniprot_entry
MSRB1_RAT
resolver
amino_acid_sequence
MSFCSFFGGEVFQNHFEPGVYVCAKCGYELFSSRSKYAHSSPWPAFTETIHEDSVAKCPEKNRPEALKVSCGKCGNGLGHEFLNDGPKRGQSRFUIFSSSLKFIPKGKEAPASQGD
uniprot
proteins
ec_number
1.8.4.12
uniprot
proteins
ec_number
1.8.4.14
uniprot
proteins
function
FUNCTION: Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages. {ECO:0000250|UniProtKB:Q9JLC3}.
uniprot
proteins
mass_dalton
12797
uniprot
proteins
post_translational_modification
PTM: Truncated MSRB1/SEPX1 proteins produced by failed UGA/Sec decoding are ubiquitinated by the CRL2(FEM1C) E3 ubiquitin-protein ligase complex. {ECO:0000250|UniProtKB:Q9NZV6}.
uniprot
proteins
protein_family
MsrB Met sulfoxide reductase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
116
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9JLC3}. Nucleus {ECO:0000250|UniProtKB:Q9JLC3}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9JLC3}.
uniprot
proteins