Mkrn2
entrez
67027
canonical
uniprot
Q9ERV1
canonical
ensembl
ENSMUSG00000000439
resolver
ensp
ENSMUSP00000000449
resolver
enst
ENSMUST00000000449
resolver
genesymbol
Mkrn2
resolver
uniprot
Q6GTY9
resolver
uniprot
Q9D0L9
resolver
uniprot_entry
MKRN2_MOUSE
resolver
uniprot_sec
Q6GTY9
resolver
uniprot_sec
Q9D0L9
resolver
amino_acid_sequence
MSTKQVTCRYFMHGVCREGSQCLFSHDLANSKPSTICKYYQKGYCAYGARCRYDHTKPPAAAGGAVGPAPNPSPSSGLHSPHPSPDIATSVMRTHSNEPGKREKKTLVLRDRNLTGLAEDKTPPSKVNNPGGCSDPQTSPEMKPHSYLDAIRTGLDDLEASSSYSNEPQLCPYAAAGECRFGDACVYLHGDMCEICRLQVLHPFDPEQRKAHEKMCMSTFEHEMEKAFAFQASQDKVCSICMEVILEKASASERRFGILSNCSHTYCLSCIRQWRCAKQFENPIIKSCPECRVISEFVIPSVYWVEDQNKKNELIEAFKQGMGKKACKYFEQGKGTCPFGSKCLYRHAYPDGRLAEPEKPRKQLSSEGTVRFFNSVRLWDFIENRETRQVPSTDDVDVTELGDLFMHLSGVESSEP
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:28378844). Promotes the polyubiquitination and proteasome-dependent degradation of RELA/p65, thereby suppressing RELA-mediated NF-kappa-B transactivation and negatively regulating inflammatory responses (PubMed:28378844). Plays a role in the regulation of spermiation and in male fertility (PubMed:28008940). {ECO:0000269|PubMed:28008940, ECO:0000269|PubMed:28378844}.
uniprot
proteins
mass_dalton
46597
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
11597136
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28008940
uniprot
proteins
pubmed
28378844
uniprot
proteins
sequence_length
416
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28378844}. Nucleus {ECO:0000269|PubMed:28378844}.
uniprot
proteins