Ehmt1
entrez
77683
canonical
uniprot
Q5DW34
canonical
ensembl
ENSMUSG00000036893
resolver
ensp
ENSMUSP00000046077
resolver
ensp
ENSMUSP00000088906
resolver
ensp
ENSMUSP00000100002
resolver
ensp
ENSMUSP00000110075
resolver
ensp
ENSMUSP00000119057
resolver
ensp
ENSMUSP00000208353
resolver
ensp
ENSMUSP00000208354
resolver
ensp
ENSMUSP00000208355
resolver
ensp
ENSMUSP00000208356
resolver
ensp
ENSMUSP00000208361
resolver
ensp
ENSMUSP00000208362
resolver
ensp
ENSMUSP00000208364
resolver
ensp
ENSMUSP00000208365
resolver
ensp
ENSMUSP00000208369
resolver
ensp
ENSMUSP00000208370
resolver
ensp
ENSMUSP00000208377
resolver
ensp
ENSMUSP00000208378
resolver
ensp
ENSMUSP00000208380
resolver
enst
ENSMUST00000102938
resolver
genesymbol
Ehmt1
resolver
genesymbol_syn
Euhmtase1
resolver
genesymbol_syn
Glp
resolver
genesymbol_syn
Kmt1d
resolver
uniprot
A0A0H2UH19
resolver
uniprot
A2AIS3
resolver
uniprot
A2AIS4
resolver
uniprot
Q5EBR1
resolver
uniprot
Q6PGM0
resolver
uniprot
Q8BHB2
resolver
uniprot
Q8C358
resolver
uniprot_entry
A0A0H2UH19_MOUSE
resolver
uniprot_entry
EHMT1_MOUSE
resolver
uniprot_entry
Q8BHB2_MOUSE
resolver
uniprot_entry
Q8C358_MOUSE
resolver
uniprot_sec
A2AIS3
resolver
uniprot_sec
A2AIS4
resolver
uniprot_sec
Q5EBR1
resolver
uniprot_sec
Q6PGM0
resolver
activity_regulation
ACTIVITY REGULATION: Methyltransferase activity is inhibited by BIX-01294. Efficiently inhibited by compound E72, a BIX-01294 derivative in which the diazepane ring and the benzyl are replaced with a 3-dimethylaminopropyl and a 5-aminopentyl group at sites B and C, respectively (By similarity). {ECO:0000250|UniProtKB:Q9H9B1}.
uniprot
proteins
amino_acid_sequence
MAAADAEQAVLAKQETKQDCCMKTELLREDTPMAADEGSTEKQEGETPMAADGETNGSCEKSGDPSHLNAPKHTQENTRASPQEGTNRVSRVAENGVSERDTEVGKQNHVTADDFMQTSVIGSNGYFLNKPALQGQPLRTPNILTSSLPGHAAKTLPGGASKCRTLSALPQTPTTAPTVPGEGSADTEDRKPTASGTDVRVHRARKTMPKSILGLHAASKDHREVQDHKEPKEDINRNISECGRQQLLPTFPALHQSLPQNQCYMATTKSQTACLPFVLAAAVSRKKKRRMGTYSLVPKKKTKVLKQRTVIEMFKSITHSTVGAKGEKALDDSALHVNGESLEMDSEDEDSDELEDDEDHGAEQAAAFPTEDSRTSKESMSETDRAAKMDGDSEEEQESPDTGEDEDGGDESDLSSESSIKKKFLKRRGKTDSPWIKPARKRRRRSRKKPSSMLGSEACKSSPGSMEQAALGDSAGYMEVSLDSLDLRVRGILSSQTENEGLASGPDVLGTDGLQEVPLCSCRMETPKSREISTLANNQCMATESVDHELGRCTNSVVKYELMRPSNKAPLLVLCEDHRGRMVKHQCCPGCGYFCTAGNFMECQPESSISHRFHKDCASRVNNASYCPHCGEEASKAKEVTIAKADTTSTVTLAPGQEKSLAAEGRADTTTGSIAGAPEDERSQSTAPQAPECFDPAGPAGLVRPTSGLSQGPGKETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQSKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLDAVKYLIKAGAQVDPKDAEGSTCLHLAAKKGHYDVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVELVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCASLSSQVWSALQMSKALRDSAPDKPVAVEKTVSRDIARGYERIPIPCVNAVDSELCPTNYKYVSQNCVTSPMNIDRNITHLQYCVCVDDCSSSTCMCGQLSMRCWYDKDGRLLPEFNMAEPPLIFECNHACSCWRNCRNRVVQNGLRARLQLYRTQDMGWGVRSLQDIPLGTFVCEYVGELISDSEADVREEDSYLFDLDNKDGEVYCIDARFYGNVSRFINHHCEPNLVPVRVFMSHQDLRFPRIAFFSTRLIQAGEQLGFDYGERFWDVKGKLFSCRCGSSKCRHSSAALAQRQASAAQEPQENGLPDTSSAAAADPL
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
ec_number
2.1.1.367
uniprot
proteins
function
FUNCTION: Histone methyltransferase that specifically mono-, di- and trimethylates 'Lys-9' of histone H3 (H3K9me1, H3K9me2 and H3K9me3, respectively) in euchromatin (PubMed:15774718, PubMed:24196706). H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones (PubMed:15774718, PubMed:24196706). Also weakly methylates 'Lys-27' of histone H3 (H3K27me) (PubMed:15774718). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently (PubMed:18818694). Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1 (By similarity). During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle (By similarity). Involved in the differentiation of myoblastic precursors into brown adipose cells: following recruitment to chromatin by PRDM16, mediates formation of H3K9me2 and H3K9me3, inhibiting the expression of white adipose-selective genes (PubMed:24196706). Also involved in the differentiation of beige adipocytes from white adipose cells following recruitment by PRDM16 (PubMed:35978186). EHMT1 also promotes protein stabilization of PRDM16, by preventing PRDM16 ubiquitination and degradation (PubMed:24196706). In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53 (By similarity). Represses the expression of mitochondrial function-related genes, perhaps by occupying their promoter regions, working in concert with probable chromatin reader BAZ2B (PubMed:32103178). {ECO:0000250|UniProtKB:Q9H9B1, ECO:0000269|PubMed:15774718, ECO:0000269|PubMed:18818694, ECO:0000269|PubMed:24196706, ECO:0000269|PubMed:32103178, ECO:0000269|PubMed:35978186}.
uniprot
proteins
mass_dalton
141999
uniprot
proteins
mutagenesis
MUTAGEN 1153; /note="Y->V: In LM7; does not prevent methyltransferase activity; when associated with F-1240."; /evidence="ECO:0000269|PubMed:18818694"; MUTAGEN 1198..1201; /note="Missing: In LM3; does not form heterodimer with EHMT2 and is defective in mediating both H3K9me and DNA methylation."; /evidence="ECO:0000269|PubMed:18818694"; MUTAGEN 1198..1199; /note="NH->LE: Abolished histone methyltransferase activity, preventing differentiation of brown adipose cells."; /evidence="ECO:0000269|PubMed:24196706"; MUTAGEN 1201; /note="C->A: In LM4; does not prevent methyltransferase activity."; /evidence="ECO:0000269|PubMed:18818694"; MUTAGEN 1240; /note="Y->F: In LM7; does not prevent methyltransferase activity; when associated with V-1153."; /evidence="ECO:0000269|PubMed:18818694
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15774718
uniprot
proteins
pubmed
18818694
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21131967
uniprot
proteins
pubmed
22629437
uniprot
proteins
pubmed
24196706
uniprot
proteins
pubmed
32103178
uniprot
proteins
pubmed
35978186
uniprot
proteins
pubmed
37405986
uniprot
proteins
sequence_length
1296
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15774718}. Chromosome {ECO:0000269|PubMed:15774718, ECO:0000269|PubMed:24196706}. Note=Associates with euchromatic regions. {ECO:0000269|PubMed:15774718}.
uniprot
proteins