Hpd
entrez
29531
canonical
uniprot
P32755
canonical
ensembl
ENSRNOG00000001338
resolver
ensembl
ENSRNOG00055015643
resolver
ensembl
ENSRNOG00060003174
resolver
ensembl
ENSRNOG00065006407
resolver
ensp
ENSRNOP00000085869
resolver
ensp
ENSRNOP00055021625
resolver
ensp
ENSRNOP00060003848
resolver
ensp
ENSRNOP00065007162
resolver
enst
ENSRNOT00055026676
resolver
enst
ENSRNOT00060005212
resolver
enst
ENSRNOT00065009858
resolver
genesymbol
Hpd
resolver
uniprot
O88655
resolver
uniprot_entry
HPPD_RAT
resolver
uniprot_sec
O88655
resolver
amino_acid_sequence
MTTYSNKGPKPERGRFLHFHSVTFWVGNAKQAASFYCNKMGFEPLAYKGLETGSREVVSHVIKQGKIVFVLCSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCEHIVQKARERGAKIVREPWVEEDKFGKVKFAVLQTYGDTTHTLVEKINYTGRFLPGFEAPTYKDTLLPKLPSCNLEIIDHIVGNQPDQEMESASEWYLKNLQFHRFWSVDDTQVHTEYSSLRSIVVANYEESIKMPINEPAPGRKKSQIQEYVDYNGGAGVQHIALRTEDIITTIRHLRERGMEFLAVPSSYYRLLRENLKTSKIQVKENMDVLEELKILVDYDEKGYLLQIFTKPMQDRPTLFLEVIQRHNHQGFGAGNFNSLFKAFEEEQALRGNLTDLETNGVRSGM
uniprot
proteins
ec_number
1.13.11.27
uniprot
proteins
ec_number
2.1.1.348
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism (PubMed:15301540, PubMed:8814303). In addition may act as a N6-methyltransferase that methylates adenosine residues at the N(6) position of some RNAs (By similarity). {ECO:0000250|UniProtKB:P32754, ECO:0000269|PubMed:15301540, ECO:0000269|PubMed:8814303}.
uniprot
proteins
mass_dalton
45112
uniprot
proteins
mutagenesis
MUTAGEN 241; /note="N->S: Results in altered 4-hydroxyphenylpyruvate dioxygenase activity and accumulation of quinolacetic acid."; /evidence="ECO:0000269|PubMed:20677779
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.
uniprot
proteins
protein_family
4HPPD family
uniprot
proteins
pubmed
12867153
uniprot
proteins
pubmed
15301540
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20677779
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2445820
uniprot
proteins
pubmed
8814303
uniprot
proteins
sequence_length
393
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12867153}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:12867153}; Peripheral membrane protein {ECO:0000269|PubMed:12867153}. Golgi apparatus membrane {ECO:0000269|PubMed:12867153}; Peripheral membrane protein {ECO:0000269|PubMed:12867153}. Nucleus {ECO:0000250|UniProtKB:P32754}.
uniprot
proteins