Glra4
entrez
14657
canonical
uniprot
Q61603
canonical
ensembl
ENSMUSG00000018595
resolver
ensp
ENSMUSP00000018739
resolver
enst
ENSMUST00000018739
resolver
genesymbol
Glra4
resolver
uniprot
A2AEA9
resolver
uniprot
Q2TB05
resolver
uniprot
Q45V76
resolver
uniprot
Q8VHF3
resolver
uniprot_entry
GLRA4_MOUSE
resolver
uniprot_entry
Q2TB05_MOUSE
resolver
uniprot_sec
A2AEA9
resolver
uniprot_sec
Q45V76
resolver
uniprot_sec
Q8VHF3
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by strychnine (PubMed:10762330). {ECO:0000269|PubMed:10762330}.
uniprot
proteins
amino_acid_sequence
MTTLVPASLFLLLWTLPGKVLLSVALAKEDVKSGLKGSQPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNVFLRQQWNDPRLAYREYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLILSCPMDLKNFPMDIQTCTMQLESFGYTMNDLMFEWLEDAPAVQVAEGLTLPQFILRDEKDLGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFMRLRRRQRRQRMEEDIIRESRFYFRGYGLGHCLQARDGGPMEGSSIYSPQPPTPLLKEGETMRKLYVDRAKRIDTISRAVFPFTFLVFNIFYWVVYKVLRSEDIHQAL
uniprot
proteins
function
FUNCTION: Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine (PubMed:10762330). Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (Probable). {ECO:0000269|PubMed:10762330, ECO:0000305}.
uniprot
proteins
mass_dalton
52514
uniprot
proteins
protein_family
GLRA4 sub-subfamily
uniprot
proteins
protein_family
Glycine receptor (TC 1.A.9.3) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
10762330
uniprot
proteins
pubmed
17154252
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22592841
uniprot
proteins
pubmed
7507926
uniprot
proteins
sequence_length
456
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000305|PubMed:17154252}; Multi-pass membrane protein {ECO:0000305}. Synapse {ECO:0000269|PubMed:17154252, ECO:0000269|PubMed:22592841}. Perikaryon {ECO:0000269|PubMed:17154252}. Cell projection, dendrite {ECO:0000269|PubMed:17154252}. Cell membrane {ECO:0000269|PubMed:10762330, ECO:0000269|PubMed:22592841, ECO:0000305|PubMed:17154252}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 257..278; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P23415"; TRANSMEM 284..304; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P23415"; TRANSMEM 316..336; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P23415"; TRANSMEM 424..444; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P23415
uniprot
proteins