Tex264
entrez
21767
canonical
uniprot
E9Q137
canonical
ensembl
ENSMUSG00000040813
resolver
ensp
ENSMUSP00000044654
resolver
ensp
ENSMUSP00000132247
resolver
ensp
ENSMUSP00000133194
resolver
genesymbol
Tex264
resolver
uniprot
Q3TXY2
resolver
uniprot
Q99LS5
resolver
uniprot
Q9D7D9
resolver
uniprot_entry
TX264_MOUSE
resolver
uniprot_sec
Q3TXY2
resolver
uniprot_sec
Q99LS5
resolver
uniprot_sec
Q9D7D9
resolver
amino_acid_sequence
MPDLLLLGLIGALTLLLLLTLLAFAGYSGLLTGVTVSAGSPPIRNITVAYKFHVGSYGDTGHLFTESCSISPKLRSIAVYYDNPHTVPPEKCRCAVGSILSEGEESPSPELIHLYQKFGFKIFSFPAPSHVVIATFPYTTPISIWLAARRVHPALDTYIKERKLCAHPRLEIYHQDKIHFMCPLARQGDFYVPEVKETERKCRELAEATDTQTDGTGADTSDASSVSLDVRPGSRETSATTLSPGAGNRGWDDGDNRSEHSYSESGASGSSFEELDLEGEGPLGEPRLNPEAKLLGPPRELSTPERGEE
uniprot
proteins
function
FUNCTION: Major reticulophagy (also called ER-phagy) receptor that acts independently of other candidate reticulophagy receptors to remodel subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover. The ATG8-containing isolation membrane (IM) cradles a tubular segment of TEX264-positive ER near a three-way junction, allowing the formation of a synapse of 2 juxtaposed membranes with trans interaction between the TEX264 and ATG8 proteins. Expansion of the IM would extend the capture of ER, possibly through a 'zipper-like' process involving continued trans TEX264-ATG8 interactions, until poorly understood mechanisms lead to the fission of relevant membranes and, ultimately, autophagosomal membrane closure. Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: acts by bridging VCP/p97 to covalent DNA-protein cross-links (DPCs) and initiating resolution of DPCs by SPRTN. {ECO:0000250|UniProtKB:Q9Y6I9}.
uniprot
proteins
mass_dalton
33590
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
309
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Y6I9}; Single-pass type III membrane protein {ECO:0000250|UniProtKB:Q9Y6I9}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:Q9Y6I9}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9Y6I9}. Nucleus {ECO:0000250|UniProtKB:Q9Y6I9}. Chromosome {ECO:0000250|UniProtKB:Q9Y6I9}. Note=Is trafficked from tubular ER to growing autophagosomes via its cytosolic LIR motif. Also found in the cytosol, nucleus and chromatin. In response to formation of covalent DNA-protein cross-links (DPCs), localizes to the nuclear periphery, and associates with DNA replication forks. {ECO:0000250|UniProtKB:Q9Y6I9}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins