ASIC3
entrez
9311
canonical
uniprot
Q9UHC3
canonical
ensembl
ENSG00000213199
resolver
ensp
ENSP00000297512
resolver
ensp
ENSP00000344838
resolver
ensp
ENSP00000350600
resolver
genesymbol
ASIC3
resolver
genesymbol_syn
ACCN3
resolver
genesymbol_syn
DRASIC
resolver
genesymbol_syn
SLNAC1
resolver
genesymbol_syn
TNAC1
resolver
hgnc
HGNC:101
resolver
uniprot
B2R9V0
resolver
uniprot
O60263
resolver
uniprot
O75906
resolver
uniprot
Q59FN9
resolver
uniprot
Q9UER8
resolver
uniprot
Q9UHC4
resolver
uniprot_entry
ASIC3_HUMAN
resolver
uniprot_sec
B2R9V0
resolver
uniprot_sec
O60263
resolver
uniprot_sec
O75906
resolver
uniprot_sec
Q59FN9
resolver
uniprot_sec
Q9UER8
resolver
uniprot_sec
Q9UHC4
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by the diuretic drug amiloride (PubMed:10842183, PubMed:9744806, PubMed:9886053). Inhibited by the diuretic drug triamterene (PubMed:9744806). Potentiated by the vertebrate neuropeptide FF (NPFF) and the related FMRFamide (PubMed:11587714). Specifically and reversibly inhibited by the a sea anemone toxin APETx2 (PubMed:15044953). {ECO:0000269|PubMed:10842183, ECO:0000269|PubMed:11587714, ECO:0000269|PubMed:15044953, ECO:0000269|PubMed:9744806, ECO:0000269|PubMed:9886053}.
uniprot
proteins
amino_acid_sequence
MKPTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAEHAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIFTRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLRKDSCACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQRHSSTNLLQEGLGSHRTQVPHLSLGPRPPTPPCAVTKTLSASHRTCYLVTQL
uniprot
proteins
function
FUNCTION: Forms pH-gated heterotrimeric sodium channels that act as postsynaptic excitatory receptors in the nervous system (PubMed:10842183, PubMed:11587714, PubMed:9744806, PubMed:9886053). Upon extracellular acidification, these channels generate a biphasic current with a fast inactivating and a slow sustained phase (PubMed:10842183, PubMed:9744806, PubMed:9886053). ASIC3 is more sensitive to protons and gates between closed, open, and desensitized states faster than other ASICs (By similarity). Displays high selectivity for sodium ions but can also permit the permeation of other cations (PubMed:9744806, PubMed:9886053). As a neuronal acid sensor, probably contributes to mechanoreception, acid nociception, and heat nociception (By similarity). By forming heterotrimeric channels with ASIC2, generates a biphasic current with a fast inactivating and a slow sustained phase, which in sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissues (By similarity). {ECO:0000250|UniProtKB:O35240, ECO:0000250|UniProtKB:Q6X1Y6, ECO:0000269|PubMed:10842183, ECO:0000269|PubMed:11587714, ECO:0000269|PubMed:9744806, ECO:0000269|PubMed:9886053}.
uniprot
proteins
mass_dalton
58905
uniprot
proteins
mutagenesis
MUTAGEN 528; /note="V->A: No effect on interaction with LIN7B. No effect on interaction with MAGI1. No effect on interaction with GOPC."; /evidence="ECO:0000269|PubMed:15317815"; MUTAGEN 529; /note="T->A: Loss of interaction with LIN7B. Loss of interaction with MAGI1."; /evidence="ECO:0000269|PubMed:15317815"; MUTAGEN 530; /note="Q->A: Loss of interaction with GOPC. No effect on interaction with LIN7B. NO effect on interaction with MAGI1."; /evidence="ECO:0000269|PubMed:15317815"; MUTAGEN 531; /note="L->A: Loss of interaction with LIN7B. Loss of interaction with MAGI1. Loss of interaction with GOPC."; /evidence="ECO:0000269|PubMed:15317815
uniprot
proteins
protein_family
ASIC3 subfamily
uniprot
proteins
protein_family
Amiloride-sensitive sodium channel (TC 1.A.6) family
uniprot
proteins
pubmed
10842183
uniprot
proteins
pubmed
11587714
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15044953
uniprot
proteins
pubmed
15317815
uniprot
proteins
pubmed
9571199
uniprot
proteins
pubmed
9744806
uniprot
proteins
pubmed
9886053
uniprot
proteins
sequence_length
531
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10842183, ECO:0000269|PubMed:15317815, ECO:0000269|PubMed:9744806, ECO:0000269|PubMed:9886053}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q6X1Y6}. Note=Preferentially expressed at the plasma membrane of the soma and cellular processes of neurons (By similarity). In part cytoplasmic in cochlea cells (By similarity). Localized in specialized sensory nerve endings (By similarity). {ECO:0000250|UniProtKB:O35240, ECO:0000250|UniProtKB:Q6X1Y6}.
uniprot
proteins
transmembrane_region
TRANSMEM 44..61; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 442..460; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins