Cubn
entrez
80848
canonical
uniprot
O70244
canonical
ensembl
ENSRNOG00000029047
resolver
ensp
ENSRNOP00000075097
resolver
enst
ENSRNOT00000090064
resolver
genesymbol
Cubn
resolver
genesymbol_syn
Ifcr
resolver
uniprot
A0A0G2K9R4
resolver
uniprot_entry
A0A0G2K9R4_RAT
resolver
uniprot_entry
CUBN_RAT
resolver
amino_acid_sequence
MSSQFLWGFVTLLMIAELDGKTGKPEQRGQKRIADLHQPRMTTEEGNLVFLTSSTQNIEFRTGSLGKIKLNDEDLGECLHQIQRNKDDIIDLRKNTTGLPQNILSQVHQLNSKLVDLERDFQNLQQNVERKVCSSNPCLNGGTCVNLHDSFVCICPSQWKGLFCSEDVNECVVYSGTPFGCQSGSTCVNTVGSFRCDCTPDTYGPQCASKYNDCEQGSKQLCKHGICEDLQRVHHGQPNFHCICDAGWTTPPNGISCTEDKDECSLQPSPCSEHAQCFNTQGSFYCGACPKGWQGNGYECQDINECEINNGGCSQAPLVPCLNTPGSFSCGNCPAGFSGDGRVCTPVDICSIHNGGCHPEATCSSSPVLGSFLPVCTCPPGYTGNGYGSNGCVRLSNICSRHPCVNGQCIETVSSYFCKCDSGWSGQNCTENINDCSSNPCLNGGTCIDGINGFTCDCTSSWTGYYCQTPQAACGGILSGTQGTFAYHSPNDTYIHNVNCFWIVRTDEEKVLHVTFTFFDLESASNCPREYLQIHDGDSSADFPLGRYCGSRPPQGIHSSANALYFHLYSEYIRSGRGFTARWEAKLPECGGILTDNYGSITSPGYPGNYPPGRDCVWQVLVNPNSLITFTFGTLSLESHNDCSKDYLEIRDGPFHQDPVLGKFCTSLSTPPLKTTGPAARIHFHSDSETSDKGFHITYLTTQSDLDCGGNYTDTDGELLLPPLSGPFSHSRQCVYLITQAQGEQIVINFTHVELESQMGCSHTYIEVGDHDSLLRKICGNETLFPIRSVSNKVWIRLRIDALVQKASFRADYQVACGGMLRGEGFFRSPFYPNAYPGRRTCRWTISQPQRQVVLLNFTDFQIGSSASCDTDYIEIGPSSVLGSPGNEKFCSSNIPSFITSVYNILYVTFVKSSSMENRGFTAKFSSDKLECGEVLTASTGIIESPGHPNVYPRGVNCTWHVVVQRGQLIRLEFSSFYLEFHYNCTNDYLEIYDTAAQTFLGRYCGKSIPPSLTSNSNSIKLIFVSDSALAHEGFSINYEAIDASSVCLYDYTDNFGMLSSPNFPNNYPSNWECIYRITVGLNQQIALHFTDFTLEDYFGSQCVDFVEIRDGGYETSPLVGIYCGSVLPPTIISHSNKLWLKFKSDAALTAKGFSAYWDGSSTGCGGNLTTPTGVLTSPNYPMPYYHSSECYWRLEASHGSPFELEFQDFHLEHHPSCSLDYLAVFDGPTTNSRLIDKLCGDTTPAPIRSNKDVVLLKLRTDAGQQGRGFEINFRQRCDNVVIVNKTSGILESINYPNPYDKNQRCNWTIQATTGNTVNYTFLGFDVESYMNCSTDYVELYDGPQWMGRYCGNNMPPPGATTGSQLHVLFHTDGINSGEKGFKMQWFTHGCGGEMSGTAGSFSSPGYPNSYPHNKECIWNIRVAPGSSIQLTIHDFDVEYHTSCNYDSLEIYAGLDFNSPRIAQLCSQSPSANPMQVSSTGNELAIRFKTDSTLNGRGFNASWRAVPGGCGGIIQLSRGEIHSPNYPNNYRANTECSWIIQVERHHRVLLNITDFDLEAPDSCLRLMDGSSSTNARVASVCGRQQPPNSIIASGNSLFVRFRSGSSSQNRGFRAEFREECGGRIMTDSSDTIFSPLYPHNYLHNQNCSWIIEAQPPFNHITLSFTHFQLQNSTDCTRDFVEILDGNDYDAPVQGRYCGFSLPHPIISFGNALTVRFVTDSTRSFEGFRAIYSASTSSCGGSFYTLDGIFNSPDYPADYHPNAECVWNIASSPGNRLQLSFLSFNLENSLNCNKDFVEIREGNATGHLIGRYCGNSLPGNYSSAEGHSLWVRFVSDGSGTGMGFQARFKNIFGNNNIVGTHGKIASPFWPGKYPYNSNYKWVVNVDAYHIIHGRILEMDIEPTTNCFYDSLKIYDGFDTHSRLIGTYCGTQTESFSSSRNSLTFQFSSDSSVSGRGFLLEWFAVDVSDSTPPTIAPGACGGFMVTGDTPVHIFSPGWPREYANGADCIWIIYAPDSTVELNILSLDIEPQQSCNYDKLIVKDGDSDLSPELAVLCGVSPPGPIRSTGEYMYIRFTSDTSVAGTGFNASFHKSCGGYLHADRGVITSPKYPDTYLPNLNCSWHVLVQTGLTIAVHFEQPFQIQNRDSFCSQGDYLVLRNGPDNHSPPLGPSGRNGRFCGMYAPSTLFTSGNEMFVQFISDSSNGGQGFKIRYEAKSLACGGTVYIHDADSDGYLTSPNYPANYPQHAECIWILEAPPGRSIQLQFEDQFNIEDTPNCSVSYLELRDGANSNARLVSKLCGHTLPHSWVSSRERIYLKFHTDGGSSYMGFKAKYSIASCGGTVSGDSGVIESIGYPTLPYANNVFCQWFIRGLPGHYLTLSFEDFNLQSSPGCTKDFVEIWENHTSGRVLGRYCGNSTPSSVDTSSNVASVKFVTDGSVTASGFRLQFKSSRQVCGGDLHGPTGTFTSPNYPNPNPHARICEWTITVQEGRRIVLTFTNLRLSTQPSCNSEHLIVFNGIRSNSPLLQKLCSRVNVTNEFKSSGNTMKVVFFTDGSRPYGGFTASYTSTEDAVCGGFLPSVSGGNFSSPGYNGIRDYARNLDCEWTLSNPNRENSSISIYFLELSIESHQDCTFDVLEFRVGDADGPLIEKFCSLSAPTAPLVIPYPQVWIHFVSNERVEYTGFYIEYSFTDCGGIRTGDNGVISSPNYPNLYSAWTHCSWLLKAPEGHTITLTFSDFLLEAHPTCTSDSVTVRNGDSPGSPVIGRYCGQSVPRPIQSGSNQLIVTFNTNNQGQTRGFYATWTTNALGCGGTFHSANGTIKSPHWPQTFPENSRCSWTVITHESKHWEISFDSNFRIPSSDSQCQNSFVKVWEGRLMINKTLLATSCGDVAPSPIVTSGNIFTAVFQSEEMAAQGFSASFISRCGRTFNTSPGDIISPNFPKQYDNNMNCTYLIDADPQSLVILTFVSFHLEDRSAITGTCDHDGLHIIKGRNLSSTPLVTICGSETLRPLTVDGPVLLNFYSDAYTTDFGFKISYRAITCGGIYNESSGILRSPSYSYSNYPNNLYCVYSLHVRSSRVIIIRFNDFDVAPSNLCAHDFLEVFDGPSIGNRSLGKFCGSTRPQTVKSTNSSLTLLFKTDSSQTARGWKIFFRETIGPQQGCGGYLTEDNQSFVSPDSDSNGRYDKGLSCIWYIVAPENKLVKLTFNVFTLEGPSSAGSCVYDYVQIADGASINSYLGGKFCGSRMPAPFISSGNFLTFQFVSDVTVEMRGFNATYTFVDMPCGGTYNATSTPQNASSPHLSNIGRPYSTCTWVIAAPPQQQVQITVWDLQLPSQDCSQSYLELQDSVQTGGNRVTQFCGANYTTLPVFYSSMSTAVVVFKSGVLNRNSQVQFSYQIADCNREYNQTFGNLKSPGWPQNYDNNLDCTIILRAPQNHSISLFFYWFQLEDSRQCMNDFLEVRNGGSSTSPLLDKYCSNLLPNPVFSQSNELYLHFHSDHSVTNNGYEIIWTSSAAGCGGTLLGDEGIFTNPGFPDSYPNNTHCEWTIVAPSGRPVSVGFPFLSIDSSGGCDQNYLIVFNGPDANSPPFGPLCGINTGIAPFYASSNRVFIRFHAEYTTRLSGFEIMWSS
uniprot
proteins
function
FUNCTION: Endocytic receptor which plays a role in lipoprotein, vitamin and iron metabolism by facilitating their uptake. Acts together with LRP2 to mediate endocytosis of high-density lipoproteins, GC, hemoglobin, ALB, TF and SCGB1A1. Acts together with AMN to mediate endocytosis of the CBLIF-cobalamin complex. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the CBLIF-cobalamin complex. Ligand binding requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface. {ECO:0000269|PubMed:10811843, ECO:0000269|PubMed:11805171, ECO:0000269|PubMed:12724130, ECO:0000269|PubMed:15616221, ECO:0000269|PubMed:9153271, ECO:0000269|PubMed:9478979}.
uniprot
proteins
mass_dalton
398987
uniprot
proteins
mutagenesis
MUTAGEN 142; /note="G->E: No effect on trafficking to the cell surface."; /evidence="ECO:0000269|PubMed:29402915"; MUTAGEN 222; /note="C->S: Decreased AMN-dependent trafficking to the cell surface."; /evidence="ECO:0000269|PubMed:29402915"; MUTAGEN 334; /note="P->L: No effect on trafficking to the cell surface."; /evidence="ECO:0000269|PubMed:29402915"; MUTAGEN 651; /note="R->G: No effect on trafficking to the cell surface."; /evidence="ECO:0000269|PubMed:29402915"; MUTAGEN 653; /note="G->A,S: No effect on trafficking to the cell surface."; /evidence="ECO:0000269|PubMed:29402915"; MUTAGEN 653; /note="G->R: Decreased AMN-dependent trafficking to the cell surface."; /evidence="ECO:0000269|PubMed:29402915"; MUTAGEN 711; /note="N->D: Impaired glycosylation and loss of export to the cell surface; when associated with D-749; D-781 and D-857."; /evidence="ECO:0000269|PubMed:29402915"; MUTAGEN 749; /note="N->D: Impaired glycosylation and loss of export to the cell surface; when associated with D-711; D-781 and D-857."; /evidence="ECO:0000269|PubMed:29402915"; MUTAGEN 781; /note="N->D: Impaired glycosylation and loss of export to the cell surface; when associated with D-711; D-749 and D-857."; /evidence="ECO:0000269|PubMed:29402915"; MUTAGEN 829; /note="S->L: Decreased AMN-dependent trafficking to the cell surface."; /evidence="ECO:0000269|PubMed:29402915"; MUTAGEN 857; /note="N->D: Impaired glycosylation and loss of export to the cell surface; when associated with D-711; D-749 and D-781."; /evidence="ECO:0000269|PubMed:29402915"; MUTAGEN 865; /note="S->N: No effect on trafficking to the cell surface."; /evidence="ECO:0000269|PubMed:29402915
uniprot
proteins
post_translational_modification
PTM: The precursor is cleaved by a trans-Golgi proteinase furin, removing a propeptide. {ECO:0000250|UniProtKB:O60494}.; PTM: N-glycosylated. {ECO:0000269|PubMed:29402915, ECO:0000269|PubMed:9478979}.
uniprot
proteins
pubmed
10400683
uniprot
proteins
pubmed
10811843
uniprot
proteins
pubmed
11805171
uniprot
proteins
pubmed
12724130
uniprot
proteins
pubmed
14576052
uniprot
proteins
pubmed
15616221
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
20237569
uniprot
proteins
pubmed
29402915
uniprot
proteins
pubmed
9153271
uniprot
proteins
pubmed
9478979
uniprot
proteins
pubmed
9691015
uniprot
proteins
sequence_length
3623
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29402915}; Peripheral membrane protein {ECO:0000305|PubMed:29402915}. Endosome membrane {ECO:0000269|PubMed:9478979}; Peripheral membrane protein {ECO:0000269|PubMed:9478979}. Lysosome membrane {ECO:0000269|PubMed:9478979}; Peripheral membrane protein {ECO:0000269|PubMed:9478979}. Note=Lacks a transmembrane domain and depends on interaction with AMN for location at the plasma membrane (By similarity). Colocalizes with AMN and LRP2 in the endocytotic apparatus of epithelial cells (PubMed:9478979). {ECO:0000250|UniProtKB:O60494, ECO:0000269|PubMed:9478979}.
uniprot
proteins