Fam220a
entrez
67238
canonical
uniprot
Q3ZN08
canonical
ensembl
ENSMUSG00000083012
resolver
ensp
ENSMUSP00000142548
resolver
ensp
ENSMUSP00000143202
resolver
enst
ENSMUST00000196487
resolver
enst
ENSMUST00000200267
resolver
genesymbol
Fam220a
resolver
genesymbol_syn
Acpin1
resolver
genesymbol_syn
Sipar
resolver
uniprot
B2RVG9
resolver
uniprot
Q8BPE1
resolver
uniprot
Q99JV7
resolver
uniprot
Q9D5Z1
resolver
uniprot_entry
F220A_MOUSE
resolver
uniprot_sec
B2RVG9
resolver
uniprot_sec
Q8BPE1
resolver
uniprot_sec
Q99JV7
resolver
uniprot_sec
Q9D5Z1
resolver
amino_acid_sequence
MKAGRGTLGVCLAKQSQGGDPDKLACGLKKRSQKRNPSPSVVPSWTDQPVADSHGKSRATGAAASEMKHGQSKASLLHHGGFKVLQSLKGSVGRSSAPAASLGKAVALSPAPSEEQLAGMSHGIGDALGSDWPGREPRATDNRGQYLKGESWVSGRPGHPKLREVGFLRGEPPSAGPKGLGTWSELSHRYFELGQLPYAYPYYKVLPEGELRCVSLDRFNPGLSEETVEDEKTLKFFRWSADSRGVTGSAIFQISKSLMP
uniprot
proteins
function
FUNCTION: Promotes dephosphorylation of transcriptional activator STAT3 by interacting with both STAT3 and protein phosphatase PTPN2 (PubMed:23917203, PubMed:26026268). This promotes interaction of PTPN2 with STAT3 and mediates STAT3 dephosphorylation by PTPN2, leading to negative regulation of STAT3 transcriptional activator activity (PubMed:23917203, PubMed:26026268). May be required for spermiogenesis or sperm function (PubMed:19659802). {ECO:0000269|PubMed:19659802, ECO:0000269|PubMed:23917203, ECO:0000269|PubMed:26026268}.
uniprot
proteins
mass_dalton
27752
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19659802
uniprot
proteins
pubmed
23917203
uniprot
proteins
pubmed
26026268
uniprot
proteins
sequence_length
260
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23917203, ECO:0000269|PubMed:26026268}. Cytoplasm {ECO:0000269|PubMed:23917203}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:19659802}. Note=Localizes to both nucleus and cytoplasm but located predominantly in the nucleus (PubMed:23917203). Detected in the sperm acrosome prior to the acrosome reaction and is likely to be released from acrosome-reacted sperm (PubMed:19659802). {ECO:0000269|PubMed:19659802, ECO:0000269|PubMed:23917203}.
uniprot
proteins