MCC
entrez
4163
canonical
uniprot
P23508
canonical
ensembl
ENSG00000171444
resolver
ensp
ENSP00000305617
resolver
ensp
ENSP00000386227
resolver
genesymbol
MCC
resolver
hgnc
HGNC:6935
resolver
uniprot
D3DT05
resolver
uniprot
Q6ZR04
resolver
uniprot_entry
CRCM_HUMAN
resolver
uniprot_sec
D3DT05
resolver
uniprot_sec
Q6ZR04
resolver
amino_acid_sequence
MNSGVAMKYGNDSSAELSELHSAALASLKGDIVELNKRLQQTERERDLLEKKLAKAQCEQSHLMREHEDVQERTTLRYEERITELHSVIAELNKKIDRLQGTTIREEDEYSELRSELSQSQHEVNEDSRSMDQDQTSVSIPENQSTMVTADMDNCSDLNSELQRVLTGLENVVCGRKKSSCSLSVAEVDKHIEQLTTASEHCDLAIKTVEEIEGVLGRDLYPNLAEERSRWEKELAGLREENESLTAMLCSKEEELNRTKATMNAIREERDRLRRRVRELQTRLQSVQATGPSSPGRLTSTNRPINPSTGELSTSSSSNDIPIAKIAERVKLSKTRSESSSSDRPVLGSEISSIGVSSSVAEHLAHSLQDCSNIQEIFQTLYSHGSAISESKIREFEVETERLNSRIEHLKSQNDLLTITLEECKSNAERMSMLVGKYESNATALRLALQYSEQCIEAYELLLALAESEQSLILGQFRAAGVGSSPGDQSGDENITQMLKRAHDCRKTAENAAKALLMKLDGSCGGAFAVAGCSVQPWESLSSNSHTSTTSSTASSCDTEFTKEDEQRLKDYIQQLKNDRAAVKLTMLELESIHIDPLSYDVKPRGDSQRLDLENAVLMQELMAMKEEMAELKAQLYLLEKEKKALELKLSTREAQEQAYLVHIEHLKSEVEEQKEQRMRSLSSTSSGSKDKPGKECADAASPALSLAELRTTCSENELAAEFTNAIRREKKLKARVQELVSALERLTKSSEIRHQQSAEFVNDLKRANSNLVAAYEKAKKKHQNKLKKLESQMMAMVERHETQVRMLKQRIALLEEENSRPHTNETSL
uniprot
proteins
function
FUNCTION: Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780). {ECO:0000269|PubMed:18591935, ECO:0000269|PubMed:19555689, ECO:0000269|PubMed:22480440, ECO:0000269|PubMed:24824780}.
uniprot
proteins
mass_dalton
93027
uniprot
proteins
mutagenesis
MUTAGEN 828; /note="S->A: Reduced binding to SCRIB."; /evidence="ECO:0000269|PubMed:22480440"; MUTAGEN 828; /note="S->D: Higher membrane localization, reduced formation of lamellipodia, accumulation of MYH10 at the cell cortex."; /evidence="ECO:0000269|PubMed:22480440
uniprot
proteins
protein_family
MCC family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1651563
uniprot
proteins
pubmed
1848370
uniprot
proteins
pubmed
18591935
uniprot
proteins
pubmed
19555689
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
22480440
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24824780
uniprot
proteins
pubmed
27932480
uniprot
proteins
sequence_length
829
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane. Cell projection, lamellipodium. Nucleus {ECO:0000269|PubMed:24824780}. Cytoplasm {ECO:0000269|PubMed:24824780}. Note=Colocalizes with actin at the leading edge of polarized cells.
uniprot
proteins