Asl
entrez
109900
canonical
uniprot
Q91YI0
canonical
ensembl
ENSMUSG00000025533
resolver
ensp
ENSMUSP00000123799
resolver
ensp
ENSMUSP00000124274
resolver
ensp
ENSMUSP00000124579
resolver
ensp
ENSMUSP00000125143
resolver
enst
ENSMUST00000159619
resolver
enst
ENSMUST00000160129
resolver
enst
ENSMUST00000161094
resolver
genesymbol
Asl
resolver
uniprot
Q3UFA2
resolver
uniprot_entry
ARLY_MOUSE
resolver
uniprot_sec
Q3UFA2
resolver
activity_regulation
ACTIVITY REGULATION: Enzyme activity is regulated by acetylation. {ECO:0000250|UniProtKB:P04424}.
uniprot
proteins
amino_acid_sequence
MASESGKLWGGRFVGAVDPIMEKFNSSISYDRHLWNVDVQGSKAYSRGLEKAGLLTKAEMQQILQGLDKVAEEWAQGTFKLHPNDEDIHTANERRLKELIGEAAGKLHTGRSRNDQVVTDLRLWMRQTCSKLSALLRVLIGTMVDRAEAERDVLFPGYTHLQRAQPIRWSHWILSHAVALTRDSERLLEVQKRINVLPLGSGAIAGNPLGVDRELLRAELNFGAITLNSMDATSERDFVAEFLFWASLCMTHLSRMAEDLILYGTKEFSFVQLSDAYSTGSSLMPQKKNPDSLELIRSKAGRVFGRCAGLLMTLKGLPSTYNKDLQEDKEAVFEVSDTMIAVLQVATGVISTLQIHRENMKQALSPDMLATDLAYYLVRKGMPFRQAHEASGKAVFMAETKGVALNLLSLQELQTISPLFSGDVSHVWDYSHSVEQYSALGGTAKSSVEWQIRQVRALLQAQEP
uniprot
proteins
ec_number
4.3.2.1
uniprot
proteins
function
FUNCTION: Catalyzes the reversible cleavage of L-argininosuccinate to fumarate and L-arginine, an intermediate step reaction in the urea cycle mostly providing for hepatic nitrogen detoxification into excretable urea as well as de novo L-arginine synthesis in nonhepatic tissues (By similarity). Essential regulator of intracellular and extracellular L-arginine pools. As part of citrulline-nitric oxide cycle, forms tissue-specific multiprotein complexes with argininosuccinate synthase ASS1, transport protein SLC7A1 and nitric oxide synthase NOS1, NOS2 or NOS3, allowing for cell-autonomous L-arginine synthesis while channeling extracellular L-arginine to nitric oxide synthesis pathway (PubMed:22081021). {ECO:0000250|UniProtKB:P04424, ECO:0000269|PubMed:22081021}.
uniprot
proteins
mass_dalton
51739
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. {ECO:0000250|UniProtKB:P04424}.; PATHWAY: Nitrogen metabolism; urea cycle; L-arginine and fumarate from (N(omega)-L-arginino)succinate: step 1/1. {ECO:0000250|UniProtKB:P04424}.
uniprot
proteins
post_translational_modification
PTM: Acetylation modifies enzyme activity in response to alterations of extracellular nutrient availability. Acetylation increased with trichostin A (TSA) or with nicotinamide (NAM). Glucose increases acetylation by about a factor of 3 with decreasing enzyme activity. Acetylation on Lys-288 is decreased on the addition of extra amino acids resulting in activation of enzyme activity. {ECO:0000250|UniProtKB:P04424}.
uniprot
proteins
protein_family
Argininosuccinate lyase subfamily
uniprot
proteins
protein_family
Lyase 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22081021
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
464
uniprot
proteins