SYCE1
entrez
93426
canonical
uniprot
Q8N0S2
canonical
ensembl
ENSG00000171772
resolver
ensp
ENSP00000303978
resolver
ensp
ENSP00000341282
resolver
ensp
ENSP00000357503
resolver
enst
ENST00000303903
resolver
genesymbol
SYCE1
resolver
genesymbol_syn
C10orf94
resolver
hgnc
HGNC:28852
resolver
uniprot
A0A0B4J1R9
resolver
uniprot
B2RC80
resolver
uniprot
Q9BWU3
resolver
uniprot
Q9BWU4
resolver
uniprot_entry
A0A0B4J1R9_HUMAN
resolver
uniprot_entry
SYCE1_HUMAN
resolver
uniprot_sec
B2RC80
resolver
uniprot_sec
Q9BWU3
resolver
uniprot_sec
Q9BWU4
resolver
amino_acid_sequence
MAGRSLTSKAEPTAGAVDRAEKAGGQDTSSQKIEDLMEMVQKLQKVGSLEPRVEVLINRINEVQQAKKKANKDLGEARTICEALQKELDSLHGEKVHLKEILSKKQETLRILRLHCQEKESEAHRKHTMLQECKERISALNLQIEEEKNKQRQLRLAFEEQLEDLMGQHKDLWDFHMPERLAKEICALDSSKEQLLKEEKLVKATLEDVKHQLCSLCGAEGPSTLDEGLFLRSQEAAATVQLFQEEHRKAEELLAAAAQRHQQLQQKCQQQQQKRQRLKEELEKHGMQVPAQAQSTQEEEAGPGDVASPKPLKGERPGAAHQAGPDVLIGQEDTLHPDLSPRGFQEIKELF
uniprot
proteins
disease_involvement
DISEASE: Premature ovarian failure 12 (POF12) [MIM:616947]: An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. {ECO:0000269|PubMed:25062452}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Spermatogenic failure, 15 (SPGF15) [MIM:616950]: An infertility disorder caused by spermatogenesis defects and characterized by non-obstructive azoospermia due to complete meiotic maturation arrest. SPGF15 inheritance is autosomal recessive. {ECO:0000269|PubMed:25899990}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Major component of the transverse central element of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase. Requires SYCP1 in order to be incorporated into the central element. May have a role in the synaptonemal complex assembly, stabilization and recombination. {ECO:0000250|UniProtKB:Q9D495}.
uniprot
proteins
mass_dalton
39699
uniprot
proteins
protein_family
SYCE family
uniprot
proteins
pubmed
11829491
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
25062452
uniprot
proteins
pubmed
25899990
uniprot
proteins
sequence_length
351
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9D495}. Chromosome {ECO:0000250|UniProtKB:Q9D495}. Note=Associates with chromatin. In prophase I stage of meiosis, localizes in the transverse central elements of the central region between lateral elements of the synaptonemal complexes. Found only where the chromosome cores are synapsed. Colocalizes with SYCE2 in the central elements. {ECO:0000250|UniProtKB:Q9D495}.
uniprot
proteins