Epha4
entrez
13838
canonical
uniprot
Q03137
canonical
ensembl
ENSMUSG00000026235
resolver
ensp
ENSMUSP00000027451
resolver
genesymbol
Epha4
resolver
genesymbol_syn
Sek
resolver
genesymbol_syn
Sek1
resolver
uniprot
Q80VZ2
resolver
uniprot_entry
EPHA4_MOUSE
resolver
uniprot_sec
Q80VZ2
resolver
amino_acid_sequence
MAGIFYFILFSFLFGICDAVTGSRVYPANEVTLLDSRSVQGELGWIASPLEGGWEEVSIMDEKNTPIRTYQVCNVMEASQNNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKETFNLYYYESDNDKERFIRESQFGKIDTIAADESFTQVDIGDRIMKLNTEIRDVGPLSKKGFYLAFQDVGACIALVSVRVFYKKCPLTVRNLAQFPDTITGADTSSLVEVRGSCVNNSEEKDVPKMYCGADGEWLVPIGNCLCNAGHEEQNGECQACKIGYYKALSTDASCAKCPPHSYSVWEGATSCTCDRGFFRADNDAASMPCTRPPSAPLNLISNVNETSVNLEWSSPQNTGGRQDISYNVVCKKCGAGDPSKCRPCGSGVHYTPQQNGLKTTRVSITDLLAHTNYTFEIWAVNGVSKYNPSPDQSVSVTVTTNQAAPSSIALVQAKEVTRYSVALAWLEPDRPNGVILEYEVKYYEKDQNERSYRIVRTAARNTDIKGLNPLTSYVFHVRARTAAGYGDFSEPLEVTTNTVPSRIIGDGANSTVLLVSVSGSVVLVVILIAAFVISRRRSKYSKAKQEADEEKHLNQGVRTYVDPFTYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTVIQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYTTRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNPNSLKRTGSESSRPNTALLDPSSPEFSAVVSVGDWLQAIKMDRYKDNFTAAGYTTLEAVVHMSQDDLARIGITAITHQNKILSSVQAMRTQMQQMHGRMVPV
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity (PubMed:17719550). Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections (PubMed:17719550, PubMed:17785183, PubMed:9789074). May also control the segregation of motor and sensory axons during neuromuscular circuit developmen (PubMed:18403711). In addition to its role in axonal guidance plays a role in synaptic plasticity. Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis (PubMed:17143272). In the nervous system, also plays a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation (PubMed:15537875, PubMed:16802330). Additionally, its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium (PubMed:16818734). During development of the cochlear organ of Corti, regulates pillar cell separation by forming a ternary complex with ADAM10 and CADH1 which facilitates the cleavage of CADH1 by ADAM10 and disruption of adherens junctions (PubMed:30639848). Phosphorylates CAPRIN1, promoting CAPRIN1-dependent formation of a membraneless compartment (PubMed:31439799). {ECO:0000269|PubMed:15537875, ECO:0000269|PubMed:16802330, ECO:0000269|PubMed:16818734, ECO:0000269|PubMed:17143272, ECO:0000269|PubMed:17719550, ECO:0000269|PubMed:17785183, ECO:0000269|PubMed:18094260, ECO:0000269|PubMed:18403711, ECO:0000269|PubMed:30639848, ECO:0000269|PubMed:31439799, ECO:0000269|PubMed:9789074}.
uniprot
proteins
mass_dalton
109814
uniprot
proteins
mutagenesis
MUTAGEN 635; /note="V->M: Kinase dead; loss of autophosphorylation and loss of CHN1 phosphorylation. No effect on interaction with NGEF."; /evidence="ECO:0000269|PubMed:11336673, ECO:0000269|PubMed:17785183
uniprot
proteins
protein_family
Ephrin receptor subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
11336673
uniprot
proteins
pubmed
1281307
uniprot
proteins
pubmed
14516691
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15537875
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16802330
uniprot
proteins
pubmed
16818734
uniprot
proteins
pubmed
17143272
uniprot
proteins
pubmed
17719550
uniprot
proteins
pubmed
17785183
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
18094260
uniprot
proteins
pubmed
18403711
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27446912
uniprot
proteins
pubmed
30639848
uniprot
proteins
pubmed
31439799
uniprot
proteins
pubmed
8455939
uniprot
proteins
pubmed
8622893
uniprot
proteins
pubmed
9789074
uniprot
proteins
sequence_length
986
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17143272}; Single-pass type I membrane protein {ECO:0000269|PubMed:17143272}. Cell projection, axon {ECO:0000269|PubMed:17143272}. Cell projection, dendrite {ECO:0000269|PubMed:17143272}. Postsynaptic density membrane {ECO:0000250}. Early endosome {ECO:0000269|PubMed:17143272}. Cell junction, adherens junction {ECO:0000269|PubMed:30639848}. Note=Clustered upon activation and targeted to early endosome. {ECO:0000269|PubMed:17143272}.
uniprot
proteins
transmembrane_region
TRANSMEM 548..569; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins