Cdc40
entrez
71713
canonical
uniprot
Q9DC48
canonical
ensembl
ENSMUSG00000038446
resolver
ensp
ENSMUSP00000044305
resolver
enst
ENSMUST00000044166
resolver
genesymbol
Cdc40
resolver
genesymbol_syn
Prp17
resolver
genesymbol_syn
Prpf17
resolver
uniprot
B2RY33
resolver
uniprot_entry
PRP17_MOUSE
resolver
uniprot_sec
B2RY33
resolver
amino_acid_sequence
MSAAIAALAASYGSGSGSESDSDSEGSRCPLPAADSLMHLTKSPSAKLSLTVAVDSAPEVAVKEDLETGVHLDPAVKEVQYNPTYETMFAPEFGPENPFRTQQMAAPRNMLSGYAEPAHINDFMFEQQRRTFATYGYALDPSLDNHQVSAKYIGSVEEAEKNQGLTVFETGQKKTEKRKKFKENDASNIDGFLGPWAKYVDEKDVAKPSEEEQKELDEITAKRQKKGKQEEEKPGEEKTILHVKEMYDYQGRSYLHIPQDVGVNLRSSVPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGDRRCLRTFIGHSKAVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCVKFNPDEDKQNLFVAGMSDKKIVQWDIRSGEIVQEYDRHLGAVNTIVFVDENRRFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHSMPAVTLSPNGKWLACQSMDNQILIFGAQNRFRLNKKKIFKGHMVAGYACQVDFSPDMSYVISGDGNGKLNIWDWKTTKLYSRFKAHDKVCIGAVWHPHETSKVITCGWDGLIKLWD
uniprot
proteins
function
FUNCTION: Required for pre-mRNA splicing as component of the activated spliceosome (By similarity). Plays an important role in embryonic brain development; this function does not require proline peptide bond isomerization (PubMed:33220177). {ECO:0000250|UniProtKB:O60508, ECO:0000269|PubMed:33220177}.
uniprot
proteins
mass_dalton
65461
uniprot
proteins
mutagenesis
MUTAGEN 95; /note="P->A: Loss of proline isomerization; no phenotype when introduced in mice, animals are viable and fertile with no microcephaly or defective cortical lamination; no splicing defect."; /evidence="ECO:0000269|PubMed:33220177
uniprot
proteins
post_translational_modification
PTM: Undergoes isomerization of the peptide bond between Gly-94 and Pro-95. The reaction is catalyzed by PPIL1. {ECO:0000269|PubMed:33220177}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
33220177
uniprot
proteins
sequence_length
579
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O60508}. Nucleus speckle {ECO:0000250|UniProtKB:O60508}.
uniprot
proteins