SOCS5
entrez
9655
canonical
uniprot
O75159
canonical
ensembl
ENSG00000171150
resolver
ensp
ENSP00000305133
resolver
ensp
ENSP00000378330
resolver
ensp
ENSP00000531921
resolver
ensp
ENSP00000531922
resolver
ensp
ENSP00000531923
resolver
ensp
ENSP00000531924
resolver
ensp
ENSP00000599655
resolver
ensp
ENSP00000599656
resolver
ensp
ENSP00000622131
resolver
ensp
ENSP00000622132
resolver
enst
ENST00000306503
resolver
enst
ENST00000394861
resolver
enst
ENST00000861862
resolver
enst
ENST00000861863
resolver
enst
ENST00000861864
resolver
enst
ENST00000861865
resolver
enst
ENST00000929596
resolver
enst
ENST00000929597
resolver
enst
ENST00000952072
resolver
enst
ENST00000952073
resolver
genesymbol
SOCS5
resolver
genesymbol_syn
CIS6
resolver
genesymbol_syn
CISH5
resolver
genesymbol_syn
CISH6
resolver
genesymbol_syn
KIAA0671
resolver
hgnc
HGNC:16852
resolver
uniprot
Q53SD4
resolver
uniprot
Q8IYZ4
resolver
uniprot_entry
SOCS5_HUMAN
resolver
uniprot_sec
Q53SD4
resolver
uniprot_sec
Q8IYZ4
resolver
amino_acid_sequence
MDKVGKMWNNFKYRCQNLFGHEGGSRSENVDMNSNRCLSVKEKNISIGDSTPQQQSSPLRENIALQLGLSPSKNSSRRNQNCATEIPQIVEISIEKDNDSCVTPGTRLARRDSYSRHAPWGGKKKHSCSTKTQSSLDADKKFGRTRSGLQRRERRYGVSSVHDMDSVSSRTVGSRSLRQRLQDTVGLCFPMRTYSKQSKPLFSNKRKIHLSELMLEKCPFPAGSDLAQKWHLIKQHTAPVSPHSTFFDTFDPSLVSTEDEEDRLRERRRLSIEEGVDPPPNAQIHTFEATAQVNPLYKLGPKLAPGMTEISGDSSAIPQANCDSEEDTTTLCLQSRRQKQRQISGDSHTHVSRQGAWKVHTQIDYIHCLVPDLLQITGNPCYWGVMDRYEAEALLEGKPEGTFLLRDSAQEDYLFSVSFRRYNRSLHARIEQWNHNFSFDAHDPCVFHSSTVTGLLEHYKDPSSCMFFEPLLTISLNRTFPFSLQYICRAVICRCTTYDGIDGLPLPSMLQDFLKEYHYKQKVRVRWLEREPVKAK
uniprot
proteins
function
FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling. {ECO:0000269|PubMed:15590694}.
uniprot
proteins
mass_dalton
61246
uniprot
proteins
mutagenesis
MUTAGEN 406; /note="R->K: Abrogates the ability to induce EGFR degradation."; /evidence="ECO:0000269|PubMed:15590694"; MUTAGEN 484; /note="L->P: Abrogates the interaction with ELOB and ELOC and the ability to suppress EGFR signaling; when associated with F-488."; /evidence="ECO:0000269|PubMed:15590694"; MUTAGEN 488; /note="C->F: Abrogates the interaction with ELOB and ELOC and the ability to suppress EGFR signaling; when associated with P-484."; /evidence="ECO:0000269|PubMed:15590694
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation is induced by EGF. {ECO:0000269|PubMed:15590694}.
uniprot
proteins
pubmed
10773671
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15590694
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
9734811
uniprot
proteins
sequence_length
536
uniprot
proteins