Fndc4
entrez
64339
canonical
uniprot
Q3TR08
canonical
ensembl
ENSMUSG00000038552
resolver
ensp
ENSMUSP00000047185
resolver
ensp
ENSMUSP00000127404
resolver
ensp
ENSMUSP00000235216
resolver
enst
ENSMUST00000041266
resolver
enst
ENSMUST00000172435
resolver
genesymbol
Fndc4
resolver
genesymbol_syn
Fnmp1
resolver
genesymbol_syn
Frcp1
resolver
uniprot
B9EI95
resolver
uniprot
Q810E5
resolver
uniprot
Q9CYY4
resolver
uniprot_entry
B9EI95_MOUSE
resolver
uniprot_entry
FNDC4_MOUSE
resolver
uniprot_sec
Q810E5
resolver
uniprot_sec
Q9CYY4
resolver
amino_acid_sequence
MPLAPPANSVETMASLMPLSPYLSPTVLLLVSCDLGFVRADRPPSPVNVTVTHLRANSATVSWDVPEGNIVIGYSISQQRQNGPGQRVIREVNTTTRACALWGLAEDSDYTVQVRSIGLRGESPPGPRVHFRTLKGSDRLPSNSSSPGDITVEGLDGERPLQTGEVVIIVVVLLMWAAVIGLFCRQYDIIKDNDSNNNPKEKGKGPEQSPQGRPVGTTRQKKSPSINTIDV
uniprot
proteins
function
FUNCTION: [Soluble FNDC4]: Has anti-inflammatory properties. In the colon, acts on macrophages to down-regulate inflammation (PubMed:27066907). May suppress osteoclastogenesis and mature osteoclast resorptive function (PubMed:29977911). In white adipose tissue, decreases local inflammation, via interaction with GPR116 (PubMed:29787756, PubMed:34016966). Also required for proper systemic glucose tolerance, specifically sensitizing white adipocytes to insulin and promoting glucose uptake (PubMed:29787756, PubMed:34016966). The insulin sensitizing function in adipose tissue is mediated by interaction with ADGRF5/GPR116 and activation of cAMP signaling (PubMed:34016966). {ECO:0000269|PubMed:27066907, ECO:0000269|PubMed:29787756, ECO:0000269|PubMed:29977911, ECO:0000269|PubMed:34016966}.
uniprot
proteins
mass_dalton
24933
uniprot
proteins
pubmed
12384288
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
27066907
uniprot
proteins
pubmed
29787756
uniprot
proteins
pubmed
29977911
uniprot
proteins
pubmed
34016966
uniprot
proteins
sequence_length
231
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Fibronectin type III domain-containing protein 4]: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Soluble FNDC4]: Secreted {ECO:0000269|PubMed:27066907, ECO:0000269|PubMed:34016966}.
uniprot
proteins
transmembrane_region
TRANSMEM 164..184; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins