SLC16A1
entrez
6566
canonical
uniprot
P53985
canonical
ensembl
ENSG00000155380
resolver
ensembl
ENSG00000281917
resolver
ensp
ENSP00000358640
resolver
ensp
ENSP00000399104
resolver
ensp
ENSP00000441065
resolver
genesymbol
SLC16A1
resolver
genesymbol_syn
MCT1
resolver
hgnc
HGNC:10922
resolver
uniprot
B4DKS0
resolver
uniprot
Q49A45
resolver
uniprot
Q5T8R6
resolver
uniprot
Q9NSJ9
resolver
uniprot_entry
B4DKS0_HUMAN
resolver
uniprot_entry
MOT1_HUMAN
resolver
uniprot_sec
Q49A45
resolver
uniprot_sec
Q5T8R6
resolver
uniprot_sec
Q9NSJ9
resolver
activity_regulation
ACTIVITY REGULATION: Selectively inhibited by AZD3965, that acts as a competitive inhibitor binding to the central channel in the outward open conformation. {ECO:0000269|PubMed:33333023}.
uniprot
proteins
amino_acid_sequence
MPPAVGGPVGYTPPDGGWGWAVVIGAFISIGFSYAFPKSITVFFKEIEGIFHATTSEVSWISSIMLAVMYGGGPISSILVNKYGSRIVMIVGGCLSGCGLIAASFCNTVQQLYVCIGVIGGLGLAFNLNPALTMIGKYFYKRRPLANGLAMAGSPVFLCTLAPLNQVFFGIFGWRGSFLILGGLLLNCCVAGALMRPIGPKPTKAGKDKSKASLEKAGKSGVKKDLHDANTDLIGRHPKQEKRSVFQTINQFLDLTLFTHRGFLLYLSGNVIMFFGLFAPLVFLSSYGKSQHYSSEKSAFLLSILAFVDMVARPSMGLVANTKPIRPRIQYFFAASVVANGVCHMLAPLSTTYVGFCVYAGFFGFAFGWLSSVLFETLMDLVGPQRFSSAVGLVTIVECCPVLLGPPLLGRLNDMYGDYKYTYWACGVVLIISGIYLFIGMGINYRLLAKEQKANEQKKESKEEETSIDVAGKPNEVTKAAESPDQKDTDGGPKEEESPV
uniprot
proteins
disease_involvement
DISEASE: Symptomatic deficiency in lactate transport (SDLT) [MIM:245340]: Deficiency of lactate transporter may result in an acidic intracellular environment created by muscle activity with consequent degeneration of muscle and release of myoglobin and creatine kinase. This defect might compromise extreme performance in otherwise healthy individuals. {ECO:0000269|PubMed:10590411}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Hyperinsulinemic hypoglycemia, familial, 7 (HHF7) [MIM:610021]: A form of hyperinsulinemic hypoglycemia, a clinically and genetically heterogeneous disorder characterized by inappropriate insulin secretion from the pancreatic beta-cells in the presence of low blood glucose levels. HHF7 features include exercise-induced hyperinsulinism, loss of consciousness due to hypoglycemia, and hypoglycemic seizures. HHF7 inheritance is autosomal dominant. {ECO:0000269|PubMed:17701893}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Monocarboxylate transporter 1 deficiency (MCT1D) [MIM:616095]: A metabolic disorder characterized by recurrent ketoacidosis, a pathologic state due to ketone formation exceeding ketone utilization. The clinical consequences of ketoacidosis are vomiting, osmotic diuresis, dehydration, and Kussmaul breathing. The condition may progress to decreased consciousness and, ultimately, death. {ECO:0000269|PubMed:25390740, ECO:0000269|PubMed:33333023}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Bidirectional proton-coupled monocarboxylate transporter (PubMed:12946269, PubMed:32946811, PubMed:33333023). Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, acetate and the ketone bodies acetoacetate and beta-hydroxybutyrate, and thus contributes to the maintenance of intracellular pH (PubMed:12946269, PubMed:33333023). The transport direction is determined by the proton motive force and the concentration gradient of the substrate monocarboxylate. MCT1 is a major lactate exporter (By similarity). Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis (By similarity). Facilitates the protonated monocarboxylate form of succinate export, that its transient protonation upon muscle cell acidification in exercising muscle and ischemic heart (PubMed:32946811). Functions via alternate outward- and inward-open conformation states. Protonation and deprotonation of 309-Asp is essential for the conformational transition (PubMed:33333023). {ECO:0000250|UniProtKB:P53986, ECO:0000250|UniProtKB:P53987, ECO:0000269|PubMed:12946269, ECO:0000269|PubMed:32946811, ECO:0000269|PubMed:33333023}.
uniprot
proteins
mass_dalton
53944
uniprot
proteins
mutagenesis
MUTAGEN 34; /note="Y->F: Reduces lactate transmembrane transporter activity."; /evidence="ECO:0000269|PubMed:33333023"; MUTAGEN 38; /note="K->A: Complete loss of transport lactate transmembrane transporter activity."; /evidence="ECO:0000269|PubMed:33333023"; MUTAGEN 70; /note="Y->A: Abolishes binding with AZD3965."; /evidence="ECO:0000269|PubMed:33333023"; MUTAGEN 143; /note="R->H: Does not affect plasma membrane localization."; /evidence="ECO:0000269|PubMed:12946269"; MUTAGEN 143; /note="R->Q,K: Abolishes lactate transmembrane transporter activity. Reduces plasma membrane localization."; /evidence="ECO:0000269|PubMed:12946269"; MUTAGEN 151; /note="M->A: AZD3965 inhibition is reduced by approximately 2 folds. The affinity for AZD3965 is decreased by 10 folds."; /evidence="ECO:0000269|PubMed:33333023"; MUTAGEN 153; /note="G->V: Abolishes lactate transmembrane transporter activity. Abolishes expression at the cell membrane."; /evidence="ECO:0000269|PubMed:12946269"; MUTAGEN 187; /note="N->A: Decreases interaction with BSN isoform 2."; /evidence="ECO:0000269|PubMed:33333023"; MUTAGEN 281; /note="L->P: AZD3965 does not inhibit lactate transmembrane transporter activity. The affinity for AZD3965 is reduced by 55 folds."; /evidence="ECO:0000269|PubMed:33333023"; MUTAGEN 309; /note="D->A: Abolishes binding with AZD3965."; /evidence="ECO:0000269|PubMed:33333023"; MUTAGEN 309; /note="D->N: Complete loss of lactate transmembrane transporter activity."; /evidence="ECO:0000269|PubMed:33333023"; MUTAGEN 313; /note="R->A: Abolishes binding with AZD3965."; /evidence="ECO:0000269|PubMed:33333023"; MUTAGEN 367; /note="F->A: Reduces lactate transmembrane transporter activity."; /evidence="ECO:0000269|PubMed:33333023"; MUTAGEN 367; /note="F->Y: Abolishes lactate transmembrane transporter activity."; /evidence="ECO:0000269|PubMed:33333023"; MUTAGEN 371; /note="S->A: Reduces lactate transmembrane transporter activity by 50%."; /evidence="ECO:0000269|PubMed:33333023"; MUTAGEN 371; /note="S->G: AZD3965 inhibition is reduced by approximately 2 folds. The affinity for AZD3965 is decreased by 10 folds."; /evidence="ECO:0000269|PubMed:33333023
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Monocarboxylate porter (TC 2.A.1.13) family
uniprot
proteins
pubmed
10590411
uniprot
proteins
pubmed
10921872
uniprot
proteins
pubmed
11944921
uniprot
proteins
pubmed
12115955
uniprot
proteins
pubmed
12946269
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15505343
uniprot
proteins
pubmed
15901598
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17127621
uniprot
proteins
pubmed
17701893
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24390345
uniprot
proteins
pubmed
25390740
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
25957687
uniprot
proteins
pubmed
32946811
uniprot
proteins
pubmed
33333023
uniprot
proteins
pubmed
7835905
uniprot
proteins
sequence_length
500
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10921872, ECO:0000269|PubMed:12946269, ECO:0000269|PubMed:15505343, ECO:0000269|PubMed:17127621, ECO:0000269|PubMed:24390345, ECO:0000269|PubMed:25957687}; Multi-pass membrane protein {ECO:0000269|PubMed:33333023}. Basolateral cell membrane {ECO:0000250|UniProtKB:P53987}; Multi-pass membrane protein {ECO:0000269|PubMed:33333023}. Apical cell membrane {ECO:0000269|PubMed:15901598}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P53987}. Note=Expression at the cell surface requires the ancillary proteins BSG and EMB. Binds preferentially to BSG. {ECO:0000269|PubMed:10921872}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..44; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:33333023, ECO:0007744|PDB:7CKO"; TRANSMEM 56..80; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:33333023, ECO:0007744|PDB:7CKO"; TRANSMEM 85..105; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:33333023, ECO:0007744|PDB:7CKO"; TRANSMEM 110..132; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:33333023, ECO:0007744|PDB:7CKO"; TRANSMEM 147..169; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:33333023, ECO:0007744|PDB:7CKO"; TRANSMEM 175..194; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:33333023, ECO:0007744|PDB:7CKO"; TRANSMEM 262..288; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:33333023, ECO:0007744|PDB:7CKO"; TRANSMEM 296..317; /note="Helical; Name=8"; /evidence="ECO:0000269|PubMed:33333023, ECO:0007744|PDB:7CKO"; TRANSMEM 329..349; /note="Helical; Name=9"; /evidence="ECO:0000269|PubMed:33333023, ECO:0007744|PDB:7CKO"; TRANSMEM 354..375; /note="Helical; Name=10"; /evidence="ECO:0000269|PubMed:33333023, ECO:0007744|PDB:7CKO"; TRANSMEM 390..410; /note="Helical; Name=11"; /evidence="ECO:0000269|PubMed:33333023, ECO:0007744|PDB:7CKO"; TRANSMEM 422..443; /note="Helical; Name=12"; /evidence="ECO:0000269|PubMed:33333023, ECO:0007744|PDB:7CKO
uniprot
proteins