Musk
entrez
18198
canonical
uniprot
Q61006
canonical
ensembl
ENSMUSG00000057280
resolver
ensp
ENSMUSP00000081625
resolver
ensp
ENSMUSP00000099957
resolver
ensp
ENSMUSP00000136696
resolver
enst
ENSMUST00000177951
resolver
genesymbol
Musk
resolver
genesymbol_syn
Nsk2
resolver
uniprot
J3QNC9
resolver
uniprot
Q1XD56
resolver
uniprot
Q32S49
resolver
uniprot
Q32S50
resolver
uniprot
Q32SD3
resolver
uniprot
Q497X0
resolver
uniprot
Q61005
resolver
uniprot
Q61987
resolver
uniprot
Q61988
resolver
uniprot_entry
J3QNC9_MOUSE
resolver
uniprot_entry
MUSK_MOUSE
resolver
uniprot_entry
Q1XD56_MOUSE
resolver
uniprot_entry
Q32S49_MOUSE
resolver
uniprot_entry
Q32S50_MOUSE
resolver
uniprot_entry
Q32SD3_MOUSE
resolver
uniprot_entry
Q497X0_MOUSE
resolver
uniprot_sec
Q61005
resolver
uniprot_sec
Q61987
resolver
uniprot_sec
Q61988
resolver
activity_regulation
ACTIVITY REGULATION: Positively regulated by CK2. {ECO:0000269|PubMed:16818610}.
uniprot
proteins
amino_acid_sequence
MRELVNIPLLQMLTLVAFSGTEKLPKAPVITTPLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIRENGQLLTILSVEDSDDGIYCCIANNGVGGAVESCGALQVKMKPKITRPPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDNALRENSRIAVLESGSLRIHNVQKEDAGQYRCVAKNSLGTAYSKLVKLEVEVFARILRAPESHNVTFGSFVTLRCTAIGIPVPTISWIENGNAVSSGSIQESVKDRVIDSRLQLFITKPGLYTCIATNKHGEKFSTAKAAATVSIAEWSKSQKDSQGYCAQYRGEVCDAVLAKDALVFFNTSYRDPEDAQELLIHTAWNELKAVSPLCRPAAEALLCNHLFQECSPGVVPTPMPICREYCLAVKELFCAKEWQAMEGKAHRGLYRSGMHLLPVPECSKLPSMHRDPTACTRLPYLDYKKENITTFPSITSSRPSADIPNLPASTSSFAVSPAYSMTVIISIVSSFALFALLTIATLYCCRRRKEWKNKKRESTAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPKLLSLEYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADFQREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDLSTRARVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGETMVVKIADFGLSRNIYSADYYKADGNDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPYYGMAHEEVIYYVRDGNILACPENCPLELYNLMRLCWSKLPADRPSFCSIHRILQRMCERAEGTVGV
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle. Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role in acetylcholinesterase (AChE) localization at the neuromuscular junctions (NMJ) via its interaction wit COLQ (By similarity). May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation. {ECO:0000250|UniProtKB:Q62838, ECO:0000269|PubMed:11323662, ECO:0000269|PubMed:12756238, ECO:0000269|PubMed:14622576, ECO:0000269|PubMed:15340048, ECO:0000269|PubMed:8653786}.
uniprot
proteins
mass_dalton
96693
uniprot
proteins
mutagenesis
MUTAGEN 553; /note="Y->F: Loss of interaction with DOK7."; /evidence="ECO:0000269|PubMed:16794080
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by PDZRN3. Ubiquitination promotes endocytosis and lysosomal degradation. {ECO:0000269|PubMed:17576800}.; PTM: Phosphorylated (PubMed:16818610). Phosphorylation is induced by AGRIN (PubMed:18848351, PubMed:8653787). Autophosphorylated. Autophosphorylation at Tyr-553 is required for interaction with DOK7 which in turn stimulates the phosphorylation and the activation of MUSK (PubMed:16794080, PubMed:20603078). {ECO:0000269|PubMed:16794080, ECO:0000269|PubMed:16818610, ECO:0000269|PubMed:18848351, ECO:0000269|PubMed:20603078, ECO:0000269|PubMed:8653787}.; PTM: Neddylated. {ECO:0000250}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
11323662
uniprot
proteins
pubmed
12165471
uniprot
proteins
pubmed
12756238
uniprot
proteins
pubmed
14622576
uniprot
proteins
pubmed
14678832
uniprot
proteins
pubmed
15340048
uniprot
proteins
pubmed
16794080
uniprot
proteins
pubmed
16818610
uniprot
proteins
pubmed
17576800
uniprot
proteins
pubmed
18272689
uniprot
proteins
pubmed
18848351
uniprot
proteins
pubmed
19038220
uniprot
proteins
pubmed
19940021
uniprot
proteins
pubmed
20603078
uniprot
proteins
pubmed
7624144
uniprot
proteins
pubmed
8653786
uniprot
proteins
pubmed
8653787
uniprot
proteins
sequence_length
868
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000269|PubMed:19038220}; Single-pass type I membrane protein {ECO:0000269|PubMed:19038220}. Note=Localizes to the postsynaptic cell membrane of the neuromuscular junction.
uniprot
proteins
transmembrane_region
TRANSMEM 495..515; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins