Grpel2
entrez
17714
canonical
uniprot
O88396
canonical
ensembl
ENSMUSG00000024580
resolver
ensp
ENSMUSP00000053440
resolver
enst
ENSMUST00000062991
resolver
genesymbol
Grpel2
resolver
genesymbol_syn
Mt-grpel2
resolver
uniprot
Q0VB85
resolver
uniprot
Q3ULH8
resolver
uniprot
Q9CQ97
resolver
uniprot_entry
GRPE2_MOUSE
resolver
uniprot_entry
Q0VB85_MOUSE
resolver
uniprot_sec
Q3ULH8
resolver
uniprot_sec
Q9CQ97
resolver
amino_acid_sequence
MAARSLWAVQRLQRLLASGAMSESRGWLHPFSTATQRTAGEDCSSEDPPDGLGPSLAEQALRLKAVKLEKEVQDLTLRYQRAVADCENIRRRTQRCVEDAKIFGIQSFCKDLVEVADILEKTAKCCSEGAEPEDHRRTLEKVFQGLSLLEARLKSVFTKHGLEKMTPIGDKYDPHEHELICHMPAGVGVQPGTVALVRQDGYKLHGRTIRLAQVEVAVESQRRL
uniprot
proteins
function
FUNCTION: Nucleotide exchange factor (NEF) for mitochondrial HSP70 (HSPA9), facilitating the release of ADP from HSPA9 to allow ATP rebinding, which is essential for the chaperone cycle. Functions as a component of the presequence translocase-associated motor (PAM) complex, which drives ATP-dependent import of proteins into the mitochondrial matrix. In the PAM complex, supports the HSPA9-driven pulling mechanism that translocates polypeptides through the TIM23 complex. Functions as a redox-regulated component of the mitochondrial protein import and folding machinery, with its activity modulated by oxidative stress (By similarity). May control the nucleotide-dependent binding of HSPA9 to substrate proteins (By similarity). {ECO:0000250|UniProtKB:Q8TAA5, ECO:0000250|UniProtKB:Q9HAV7}.
uniprot
proteins
mass_dalton
25030
uniprot
proteins
protein_family
GrpE family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
30098457
uniprot
proteins
pubmed
9694873
uniprot
proteins
sequence_length
224
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:Q8TAA5}.
uniprot
proteins