Lpgat1
entrez
226856
canonical
uniprot
Q91YX5
canonical
ensembl
ENSMUSG00000026623
resolver
ensp
ENSMUSP00000106479
resolver
ensp
ENSMUSP00000106480
resolver
ensp
ENSMUSP00000269397
resolver
ensp
ENSMUSP00000269398
resolver
ensp
ENSMUSP00000269402
resolver
ensp
ENSMUSP00000269405
resolver
enst
ENSMUST00000110855
resolver
enst
ENSMUST00000110856
resolver
genesymbol
Lpgat1
resolver
genesymbol_syn
Fam34a
resolver
genesymbol_syn
mKIAA0205
resolver
uniprot
E9QL80
resolver
uniprot
Q3UZK0
resolver
uniprot
Q6A0A4
resolver
uniprot_entry
E9QL80_MOUSE
resolver
uniprot_entry
LGAT1_MOUSE
resolver
uniprot_entry
Q3UZK0_MOUSE
resolver
uniprot_entry
Q6A0A4_MOUSE
resolver
amino_acid_sequence
MAVTVEEAPWLGWIVAKALMRFAFMVANNLVAIPSYICYVIILQPLRVLDSKRFWYIEGLMYKWLLGMVASWGWYAGYTVMEWGEDIKAIAKDEAVMLVNHQATGDVCTLMMCLQDKGPVVAQMMWLMDHIFKYTNFGIVSLIHGDFFIRQGRAYRDQQLLVLKKHLEHNYRSRDRKWIVLFPEGGFLRKRRETSQAFAKKNNLPFLTHVTLPRFGATNIILKALVARQENGSPAGGDARGLECKSRGLQWIIDTTIAYPKAEPIDIQTWILGYRKPTVTHVHYRIFPIGDVPLETEDLTSWLYQRFIEKEDLLSHFYKTGAFPPPQGQKEAVCREMTLSNMWIFLIQSFAFLSGYLWYHIIQYFYHCLF
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
ec_number
2.3.1.22
uniprot
proteins
ec_number
2.3.1.62
uniprot
proteins
function
FUNCTION: Lysophospholipid acyltransferase involved in fatty acyl chain remodeling of glycerophospholipids in the endoplasmic reticulum membrane (PubMed:35131264). Selectively catalyzes the transfer and esterification of saturated long-chain fatty acids from acyl-CoA to the sn-1 position of 1-lyso-2-acyl phosphatidylethanolamines (1-lyso-PE, LPE), with a preference for stearoyl CoA over palmitoyl CoA as acyl donor (PubMed:36049524). Acts in concert with an unknown phospholipase A1 to convert palmitate PE species into stearate ones. Provides substrates to the PE methylation pathway, controlling stearate/palmitate composition of PE and phosphatidylcholine (PC) species with an overall impact on de novo hepatic lipid synthesis, body fat content and life span (PubMed:35131264). Can acylate lysophosphatidylglycerols (LPG) using various saturated fatty acyl-CoAs as acyl donors (By similarity). Can also acylate monoacylglycerols with a preference for 2-monoacylglycerols over 1-monoacylglycerols (PubMed:20018982, PubMed:35131264). Has no activity toward lysophosphatidic acids (LPA) and lysophosphatidylcholines (LPC) (PubMed:35131264). {ECO:0000250|UniProtKB:Q92604, ECO:0000269|PubMed:20018982, ECO:0000269|PubMed:35131264, ECO:0000269|PubMed:36049524}.
uniprot
proteins
mass_dalton
43088
uniprot
proteins
protein_family
1-acyl-sn-glycerol-3-phosphate acyltransferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20018982
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
34890643
uniprot
proteins
pubmed
35131264
uniprot
proteins
pubmed
36049524
uniprot
proteins
sequence_length
370
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q92604}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q92604}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 342..362; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins