Fem1c
entrez
240263
canonical
uniprot
Q8CEF1
canonical
ensembl
ENSMUSG00000033319
resolver
ensp
ENSMUSP00000038816
resolver
enst
ENSMUST00000036226
resolver
genesymbol
Fem1c
resolver
genesymbol_syn
Kiaa1785
resolver
uniprot
B2RRW5
resolver
uniprot
Q3UGV8
resolver
uniprot
Q8C7S4
resolver
uniprot_entry
B2RRW5_MOUSE
resolver
uniprot_entry
FEM1C_MOUSE
resolver
uniprot_sec
Q3UGV8
resolver
uniprot_sec
Q8C7S4
resolver
amino_acid_sequence
MDLKTAVFNAARDGKLRLLTKLLASKSKAEVSSLISEKTNGATPLLMAARYGHLDMVEFLLEQCSASIEVGGSVNFDGETIEGAPPLWAASAAGHLKVVQSLLNHGASVNNTTLTNSTPLRAACFDGHLEIVKYLVEHKADLEVSNRHGHTCLMISCYKGHKEIAQYLLEKGADVNRKSVKGNTALHDCAESGSLDIMKMLLMYCAKMEKDGYGMTPLLSASVTGHTNIVDFLTHHAQTSKTERINALELLGATFVDKKRDLLGALKYWKKAMNMRYSDRTNIISKPVPQTLIMAYDYAKEVNSAEELEGLIADPDEMRMQALLIRERILGPSHPDTSYYIRYRGAVYADSGNFKRCINLWKYALDMQQSNLDPLSPMTASSLLSFAELFSFMLQDRAKGLLGTTVTFDDLMGILCKSVLEIERAIKQTQCPADPLQLNKALSIILHLICLLEKVPCTVEQDHFKKQTIYRFLKLHPRGKNNFSPLHLAVDKNTTCVGRYPVCKFPSLQVTAILIECGADVNVRDSDDNSPLHIAALNNHPDIMNLLIKSGAHFDATNLHKQTASDLLDEKEIAKNLIQPINHTTLQCLAARVIVNHRIYYKGNIPEKLETFVSLHR
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (By similarity). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (By similarity). The CRL2(FEM1C) complex specifically recognizes proteins with an arginine at the C-terminus: recognizes and binds proteins ending with -Lys/Arg-Xaa-Arg and -Lys/Arg-Xaa-Xaa-Arg C-degrons, such as SIL1 or OR51B2, leading to their ubiquitination and degradation (By similarity). The CRL2(FEM1C) complex mediates ubiquitination and degradation of truncated MSRB1/SEPX1 selenoproteins produced by failed UGA/Sec decoding (By similarity). Promotes ubiquitination and degradation of SLBP (By similarity). {ECO:0000250|UniProtKB:Q96JP0}.
uniprot
proteins
mass_dalton
68578
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q96JP0}.
uniprot
proteins
protein_family
Fem-1 family
uniprot
proteins
pubmed
14527725
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15082774
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
617
uniprot
proteins