LAMP3
entrez
27074
canonical
uniprot
Q9UQV4
canonical
ensembl
ENSG00000078081
resolver
ensp
ENSP00000265598
resolver
ensp
ENSP00000785065
resolver
enst
ENST00000265598
resolver
genesymbol
LAMP3
resolver
genesymbol_syn
DCLAMP
resolver
genesymbol_syn
TSC403
resolver
hgnc
HGNC:14582
resolver
uniprot
D3DNS4
resolver
uniprot
O94781
resolver
uniprot
Q8NEC8
resolver
uniprot_entry
LAMP3_HUMAN
resolver
uniprot_sec
D3DNS4
resolver
uniprot_sec
O94781
resolver
uniprot_sec
Q8NEC8
resolver
amino_acid_sequence
MPRQLSAAAALFASLAVILHDGSQMRAKAFPETRDYSQPTAAATVQDIKKPVQQPAKQAPHQTLAARFMDGHITFQTAATVKIPTTTPATTKNTATTSPITYTLVTTQATPNNSHTAPPVTEVTVGPSLAPYSLPPTITPPAHTTGTSSSTVSHTTGNTTQPSNQTTLPATLSIALHKSTTGQKPVQPTHAPGTTAAAHNTTRTAAPASTVPGPTLAPQPSSVKTGIYQVLNGSRLCIKAEMGIQLIVQDKESVFSPRRYFNIDPNATQASGNCGTRKSNLLLNFQGGFVNLTFTKDEESYYISEVGAYLTVSDPETIYQGIKHAVVMFQTAVGHSFKCVSEQSLQLSAHLQVKTTDVQLQAFDFEDDHFGNVDECSSDYTIVLPVIGAIVVGLCLMGMGVYKIRLRCQSSGYQRI
uniprot
proteins
function
FUNCTION: Lysosomal membrane glycoprotein which plays a role in the unfolded protein response (UPR) that contributes to protein degradation and cell survival during proteasomal dysfunction (PubMed:25681212). Plays a role in the process of fusion of the lysosome with the autophagosome, thereby modulating the autophagic process (PubMed:24434718). Promotes hepatocellular lipogenesis through activation of the PI3K/Akt pathway (PubMed:29056532). May also play a role in dendritic cell function and in adaptive immunity (PubMed:9768752). {ECO:0000269|PubMed:24434718, ECO:0000269|PubMed:25681212, ECO:0000269|PubMed:29056532, ECO:0000269|PubMed:9768752}.; FUNCTION: (Microbial infection) Plays a positive role in post-entry steps of influenza A virus replication, either virus uncoating, cytosolic transport, or nuclear import of viral components, and promotes nuclear accumulation of influenza nucleoprotein/NP at early stages of viral infection. {ECO:0000269|PubMed:21810281}.; FUNCTION: (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F. {ECO:0000269|PubMed:32295904}.; FUNCTION: (Microbial infection) Promotes the intracellular proliferation of Salmonella typhimuium. {ECO:0000269|PubMed:27329040}.
uniprot
proteins
mass_dalton
44346
uniprot
proteins
protein_family
LAMP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21810281
uniprot
proteins
pubmed
21930964
uniprot
proteins
pubmed
22809326
uniprot
proteins
pubmed
24434718
uniprot
proteins
pubmed
25681212
uniprot
proteins
pubmed
27329040
uniprot
proteins
pubmed
29056532
uniprot
proteins
pubmed
32295904
uniprot
proteins
pubmed
9721848
uniprot
proteins
pubmed
9768752
uniprot
proteins
sequence_length
416
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell surface {ECO:0000269|PubMed:27329040}. Lysosome membrane {ECO:0000269|PubMed:21930964, ECO:0000269|PubMed:9768752}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:9768752}; Single-pass type I membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000269|PubMed:21810281}; Single-pass type I membrane protein {ECO:0000255}. Note=During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3 (PubMed:9768752). Detected on lysosomes in mature dendritic cells (PubMed:9768752). {ECO:0000269|PubMed:9768752}.
uniprot
proteins
transmembrane_region
TRANSMEM 382..402; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00740
uniprot
proteins