Icos
entrez
64545
canonical
uniprot
Q9R1T7
canonical
ensembl
ENSRNOG00000046196
resolver
ensembl
ENSRNOG00055021865
resolver
ensembl
ENSRNOG00060023212
resolver
ensembl
ENSRNOG00065026477
resolver
ensp
ENSRNOP00000064455
resolver
ensp
ENSRNOP00000079452
resolver
genesymbol
Icos
resolver
genesymbol_syn
Ailim
resolver
uniprot
Q9WVR9
resolver
uniprot_entry
ICOS_RAT
resolver
uniprot_sec
Q9WVR9
resolver
amino_acid_sequence
MKPYFSCVFVFCFLIKLLTGELNDLANHRMFSFHDGGVQISCNYPETVQQLKMQLFKDREVLCDLTKTKGSGNTVSIKNPMSCPYQLSNNSVSFFLDNADSSQGSYFLCSLSIFDPPPFQEKNLSGGYLLIYESQLCCQLKLWLPVGCAAFVAALLFGCIFIVWFAKKKYRSSVHDPNSEYMFMAAVNTNKKSRLAGMTS
uniprot
proteins
function
FUNCTION: Stimulatory receptor expressed in activated or antigen-experienced T-cells that plays an important role in the immune response. Upon binding to its ligand ICOSL expressed on antigen presenting cells (APCs), delivers costimulatory signals that enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines including IL10, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Also acts as a costimulatory receptor critical for the differentiation of T follicular regulatory cells upon immune challenges such as viral infection (By similarity). Mechanistically, potentiates TCR-induced calcium flux by augmenting PLCG1 activation and actin remodeling (By similarity). In addition, activates PI3K signaling pathways independently of calcium flux (By similarity). Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity). {ECO:0000250|UniProtKB:Q9WVS0, ECO:0000250|UniProtKB:Q9Y6W8}.
uniprot
proteins
mass_dalton
22529
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q9Y6W8}.
uniprot
proteins
pubmed
11006126
uniprot
proteins
sequence_length
200
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9Y6W8}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9Y6W8}.
uniprot
proteins
transmembrane_region
TRANSMEM 146..166; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins