Fxyd7
entrez
57780
canonical
uniprot
P59648
canonical
ensembl
ENSMUSG00000036578
resolver
ensp
ENSMUSP00000073555
resolver
enst
ENSMUST00000073892
resolver
genesymbol
Fxyd7
resolver
uniprot
Q8BTD2
resolver
uniprot_entry
FXYD7_MOUSE
resolver
uniprot_sec
Q8BTD2
resolver
amino_acid_sequence
MATPTQSPTNVPEETDPFFYDYATVQTVGMTLATIMFVLGIIIILSKKVKCRKADSRSESPTCKSCKSELPSSAPGGGGV
uniprot
proteins
function
FUNCTION: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane (PubMed:12093728, PubMed:15133029, PubMed:16269407). Reduces the apparent affinity for external K(+), an effect that depends on the presence of external Na(+) and voltage (PubMed:12093728, PubMed:15133029). Increases the apparent affinity for intracellular Na(+) (By similarity). {ECO:0000250|UniProtKB:P58549, ECO:0000269|PubMed:12093728, ECO:0000269|PubMed:15133029, ECO:0000269|PubMed:16269407}.
uniprot
proteins
mass_dalton
8487
uniprot
proteins
mutagenesis
MUTAGEN 3; /note="T->A: Does not affect interaction with NKA; when associated with A-5 and A-9."; /evidence="ECO:0000269|PubMed:12093728"; MUTAGEN 5; /note="T->A: Does not affect interaction with NKA; when associated with A-3 and A-9."; /evidence="ECO:0000269|PubMed:12093728"; MUTAGEN 9; /note="T->A: Does not affect interaction with NKA; when associated with A-3 and A-5."; /evidence="ECO:0000269|PubMed:12093728"; MUTAGEN 80; /note="V->A: Reduces the rate and degree of FXYD7 O-glycosylation. Decreases expression at the plasma membrane."; /evidence="ECO:0000269|PubMed:15133029
uniprot
proteins
post_translational_modification
PTM: O-glycosylated; required for stabilization and translocation to the plasma membrane. {ECO:0000269|PubMed:12093728, ECO:0000269|PubMed:15133029}.
uniprot
proteins
protein_family
FXYD family
uniprot
proteins
pubmed
10950925
uniprot
proteins
pubmed
12093728
uniprot
proteins
pubmed
15133029
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16269407
uniprot
proteins
sequence_length
80
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12093728, ECO:0000269|PubMed:15133029}; Single-pass type I membrane protein {ECO:0000269|PubMed:12093728}. Note=Able to translocate to the plasma membrane of Xenopus oocytes independent of its association with NKA. {ECO:0000250|UniProtKB:P59649}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..45; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins