Kcnh1
entrez
16510
canonical
uniprot
Q60603
canonical
ensembl
ENSMUSG00000058248
resolver
ensp
ENSMUSP00000077563
resolver
ensp
ENSMUSP00000106468
resolver
enst
ENSMUST00000078470
resolver
enst
ENSMUST00000110844
resolver
genesymbol
Kcnh1
resolver
genesymbol_syn
Eag1
resolver
uniprot
A0A1L1M1J8
resolver
uniprot
F6WD60
resolver
uniprot
Q32MR6
resolver
uniprot
Q3UHC9
resolver
uniprot
Q3USQ9
resolver
uniprot_entry
A0A1L1M1J8_MOUSE
resolver
uniprot_entry
F6WD60_MOUSE
resolver
uniprot_entry
KCNH1_MOUSE
resolver
uniprot_entry
Q3UHC9_MOUSE
resolver
uniprot_sec
Q32MR6
resolver
uniprot_sec
Q3USQ9
resolver
activity_regulation
ACTIVITY REGULATION: Channel activity is inhibited by interaction with Ca(2+)-bound calmodulin. Interaction of a single pore-forming alpha subunit with a calmodulin chain is sufficient to promote channel closure (By similarity). Channel activity is not regulated by cyclic nucleotides (PubMed:19671703). Channel activity is inhibited by binding intracellular phosphatidylinositol-3,5-bisphosphate and phosphatidylinositol-4,5-bisphosphate (PIP2), but is not inhibited by phosphatidylinositol 4-phosphate (By similarity). {ECO:0000250|UniProtKB:O95259, ECO:0000269|PubMed:19671703}.
uniprot
proteins
amino_acid_sequence
MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKSSACSFMYGELTDKDTVEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLALDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNALTDHTSANHSLVKASVVTVRESPATPVSFQAATTSTVSDHAKLHAPGSECLGPKAVSCDPAKRKGWARFKDACGKGEDWNKVSKAESMETLPERTKAPGEATLKKTDSCDSGITKSDLRLDNVGETRSPQDRSPILAEVKHSFYPIPEQTLQATVLEVKYELKEDIKALNAKMTSIEKQLSEILRILMSRGSAQSPQETGEISRPQSPESDRDIFGAS
uniprot
proteins
function
FUNCTION: Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel that mediates outward-rectifying potassium currents which, on depolarization, reaches a steady-state level and do not inactivate (PubMed:19671703, PubMed:23975098). The activation kinetics depend on the prepulse potential and external divalent cation concentration. With negative prepulses, the current activation is delayed and slowed down several fold, whereas more positive prepulses speed up activation. The time course of activation is biphasic with a fast and a slowly activating current component. Activates at more positive membrane potentials and exhibit a steeper activation curve (By similarity). Channel properties are modulated by subunit assembly. Mediates IK(NI) current in myoblasts. Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (By similarity). {ECO:0000250|UniProtKB:O95259, ECO:0000269|PubMed:19671703, ECO:0000269|PubMed:23975098}.
uniprot
proteins
mass_dalton
111282
uniprot
proteins
mutagenesis
MUTAGEN 7..8; /note="RR->AA,EE: Strongly shifts the voltage-dependent channel activation to more depolarized membrane potentials."; /evidence="ECO:0000269|PubMed:23975098"; MUTAGEN 57; /note="R->D: Decreases the rate of channel opening. No effect; when associated with R-642."; /evidence="ECO:0000269|PubMed:23975098"; MUTAGEN 627; /note="E->A,R: Strongly shifts the voltage-dependent channel activation to much more depolarized membrane potentials."; /evidence="ECO:0000269|PubMed:23975098"; MUTAGEN 628; /note="V->A,L: Mildly increases the affinity for CALM."; /evidence="ECO:0000269|PubMed:22732247"; MUTAGEN 642; /note="D->R: Decreases the rate of channel opening. No effect; when associated with D-57."; /evidence="ECO:0000269|PubMed:23975098"; MUTAGEN 697..699; /note="LTY->ATA: Increases the affinity for CALM."; /evidence="ECO:0000269|PubMed:22732247"; MUTAGEN 699..701; /note="YNL->ANA: Increases the affinity for CALM."; /evidence="ECO:0000269|PubMed:22732247"; MUTAGEN 699; /note="Y->W: Mildly increases the affinity for CALM."; /evidence="ECO:0000269|PubMed:22732247"; MUTAGEN 705..707; /note="IVF->AAA: Decreases the affinity for CALM."; /evidence="ECO:0000269|PubMed:22732247"; MUTAGEN 737; /note="V->A: No effect on affinity for CALM; when associated with A-740."; /evidence="ECO:0000269|PubMed:27618660"; MUTAGEN 737; /note="V->S: Decreases affinity for CALM 230-fold; when associated with S-740."; /evidence="ECO:0000269|PubMed:27618660"; MUTAGEN 740; /note="L->A: No effect on affinity for CALM; when associated with A-737."; /evidence="ECO:0000269|PubMed:27618660"; MUTAGEN 740; /note="L->S: Decreases affinity for CALM 230-fold; when associated with S-737."; /evidence="ECO:0000269|PubMed:27618660"; MUTAGEN 741; /note="F->S: Decreases affinity for CALM about 30-fold."; /evidence="ECO:0000269|PubMed:27618660
uniprot
proteins
post_translational_modification
PTM: Channel activity is regulated via tyrosine phosphorylation/dephosphorylation by SRC and PTPN6. {ECO:0000250|UniProtKB:O95259}.
uniprot
proteins
protein_family
H (Eag) (TC 1.A.1.20) subfamily
uniprot
proteins
protein_family
Kv10.1/KCNH1 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19671703
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22732247
uniprot
proteins
pubmed
22841712
uniprot
proteins
pubmed
23424202
uniprot
proteins
pubmed
23555008
uniprot
proteins
pubmed
23975098
uniprot
proteins
pubmed
25556795
uniprot
proteins
pubmed
27618660
uniprot
proteins
pubmed
8159766
uniprot
proteins
sequence_length
989
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19671703, ECO:0000269|PubMed:23975098}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O95259}. Nucleus inner membrane {ECO:0000250|UniProtKB:O95259}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O95259}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q63472}. Cell projection, axon {ECO:0000250|UniProtKB:Q63472}. Presynaptic cell membrane {ECO:0000269|PubMed:25556795}. Perikaryon {ECO:0000250|UniProtKB:Q63472}. Postsynaptic density membrane {ECO:0000250|UniProtKB:Q63472}. Early endosome membrane {ECO:0000250|UniProtKB:O95259}. Note=Perinuclear KCNH1 is located to NPC-free islands. {ECO:0000250|UniProtKB:O95259}.
uniprot
proteins
transmembrane_region
TRANSMEM 221..241; /note="Helical; Name=Segment S1"; /evidence="ECO:0000250|UniProtKB:Q63472"; TRANSMEM 249..269; /note="Helical; Name=Segment S2"; /evidence="ECO:0000250|UniProtKB:Q63472"; TRANSMEM 291..309; /note="Helical; Name=Segment S3"; /evidence="ECO:0000250|UniProtKB:Q63472"; TRANSMEM 346..368; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000250|UniProtKB:Q63472"; TRANSMEM 378..399; /note="Helical; Name=Segment S5"; /evidence="ECO:0000250|UniProtKB:Q63472"; TRANSMEM 478..498; /note="Helical; Name=Segment S6"; /evidence="ECO:0000250|UniProtKB:Q63472
uniprot
proteins