FCER1G
entrez
2207
canonical
uniprot
P30273
canonical
ensembl
ENSG00000158869
resolver
ensp
ENSP00000289902
resolver
enst
ENST00000289902
resolver
genesymbol
FCER1G
resolver
hgnc
HGNC:3611
resolver
uniprot
Q5VTW4
resolver
uniprot_entry
FCERG_HUMAN
resolver
uniprot_sec
Q5VTW4
resolver
amino_acid_sequence
MIPAVVLLLLLLVEQAAALGEPQLCYILDAILFLYGIVLTLLYCRLKIQVRKAAITSYEKSDGVYTGLSTRNQETYETLKHEKPPQ
uniprot
proteins
function
FUNCTION: Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a functional signaling complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of ITAM, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. May function cooperatively with other activating receptors. Functionally linked to integrin beta-2/ITGB2-mediated neutrophil activation. Also involved in integrin alpha-2/ITGA2-mediated platelet activation. {ECO:0000250|UniProtKB:P20491}.
uniprot
proteins
mass_dalton
9667
uniprot
proteins
protein_family
CD3Z/FCER1G family
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18776906
uniprot
proteins
pubmed
2138619
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26311901
uniprot
proteins
pubmed
28652325
uniprot
proteins
pubmed
8611682
uniprot
proteins
sequence_length
86
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8611682}; Single-pass type I membrane protein {ECO:0000269|PubMed:8611682}.
uniprot
proteins
transmembrane_region
TRANSMEM 24..44; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins