PLCB2
entrez
5330
canonical
uniprot
Q00722
canonical
ensembl
ENSG00000137841
resolver
ensp
ENSP00000260402
resolver
ensp
ENSP00000411991
resolver
ensp
ENSP00000444652
resolver
ensp
ENSP00000453975
resolver
ensp
ENSP00000552472
resolver
ensp
ENSP00000552473
resolver
ensp
ENSP00000619824
resolver
ensp
ENSP00000619825
resolver
enst
ENST00000543785
resolver
genesymbol
PLCB2
resolver
hgnc
HGNC:9055
resolver
uniprot
A8K6J2
resolver
uniprot
B9EGH5
resolver
uniprot
F6T0Z1
resolver
uniprot
Q59F77
resolver
uniprot
Q9BVT6
resolver
uniprot_entry
F6T0Z1_HUMAN
resolver
uniprot_entry
PLCB2_HUMAN
resolver
uniprot_entry
Q59F77_HUMAN
resolver
uniprot_entry
Q9BVT6_HUMAN
resolver
uniprot_sec
A8K6J2
resolver
uniprot_sec
B9EGH5
resolver
amino_acid_sequence
MSLLNPVLLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLDITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKAWAEDVLALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADRKRVEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGPTSSSKDTGGEAEGSSPPSAPAGEGTVWAGEEGTELEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKLKEAMGGLPEKPFPLASPVASQVNGALAPTSNGSPAARAGAREEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELGPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDGRVRELKDRLELELLRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKKKLETKRLERIQGMTKVTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERHQEKLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLEAEVKESVRACLRTCFPSEAKDKPERACECPPELCEQDPLIAKADAQESRL
uniprot
proteins
ec_number
3.1.4.11
uniprot
proteins
function
FUNCTION: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes (PubMed:1644792, PubMed:9188725). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting RASGRP4 activation by DAG, to promote neutrophil functional responses (By similarity). {ECO:0000250|UniProtKB:A3KGF7, ECO:0000269|PubMed:1644792, ECO:0000269|PubMed:9188725}.
uniprot
proteins
mass_dalton
134024
uniprot
proteins
mutagenesis
MUTAGEN 52; /note="Q->A: Strongly reduces interaction with RAC1."; /evidence="ECO:0000269|PubMed:17115053
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1644792
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
17115053
uniprot
proteins
pubmed
23625927
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9188725
uniprot
proteins
sequence_length
1185
uniprot
proteins