Pdgfc
entrez
79429
canonical
uniprot
Q9EQX6
canonical
ensembl
ENSRNOG00000010695
resolver
ensembl
ENSRNOG00055001486
resolver
ensembl
ENSRNOG00060007117
resolver
ensembl
ENSRNOG00065030449
resolver
ensp
ENSRNOP00000015081
resolver
ensp
ENSRNOP00055001825
resolver
ensp
ENSRNOP00060008801
resolver
ensp
ENSRNOP00065043156
resolver
enst
ENSRNOT00000015081
resolver
enst
ENSRNOT00055002407
resolver
enst
ENSRNOT00060011691
resolver
enst
ENSRNOT00065052511
resolver
genesymbol
Pdgfc
resolver
genesymbol_syn
Scdgf
resolver
uniprot
Q8K429
resolver
uniprot_entry
PDGFC_RAT
resolver
uniprot_sec
Q8K429
resolver
amino_acid_sequence
MLLLGLLLLTSALAGQRTGTRAESNLSSKLQLSSDKEQNGVQDPRHERVVTISGNGSIHSPKFPHTYPRNTVLVWRLVAVDENVRIQLTFDERFGLEDPEDDLCKYDFVEVEEPSDGSVLGRWCGSGTVPGKQTSKGNHIRIRFVSDEYFPSEPGFCIHYSIIMPQVTETTSPSVLPPSALSLDLLNNAVTAFSTVEELIRFLEPDRWQIDLDSLYKPTWPLLGKAFLYGKKSKAVNLNLLKEEVKLYSCTPRNFSVSIREELKRTDTIFWPGCLLVKRCGGNCACCLHNCNECQCVPRKVTKKYHEVLQLRPKIGVKGLHKSLTDVALEHHEECDCVCRGNTEG
uniprot
proteins
function
FUNCTION: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen and chemoattractant for cells of mesenchymal origin. Required for normal skeleton formation during embryonic development, especially for normal development of the craniofacial skeleton and for normal development of the palate. Required for normal skin morphogenesis during embryonic development. Plays an important role in wound healing, where it appears to be involved in three stages: inflammation, proliferation and remodeling. Plays an important role in angiogenesis and blood vessel development. Involved in fibrotic processes, in which transformation of interstitial fibroblasts into myofibroblasts plus collagen deposition occurs. The CUB domain has mitogenic activity in coronary artery smooth muscle cells, suggesting a role beyond the maintenance of the latency of the PDGF domain. In the nucleus, PDGFC seems to have additional function (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
38734
uniprot
proteins
post_translational_modification
PTM: Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after basic residues in the hinge region (region connecting the CUB and growth factor domains) gives rise to the receptor-binding form. Cleaved by PLAT and PLG (By similarity). {ECO:0000250}.; PTM: Sumoylated with SUMO1. {ECO:0000250}.; PTM: N-glycosylated. {ECO:0000250}.
uniprot
proteins
protein_family
PDGF/VEGF growth factor family
uniprot
proteins
pubmed
11162582
uniprot
proteins
pubmed
11850188
uniprot
proteins
pubmed
11912250
uniprot
proteins
pubmed
15267171
uniprot
proteins
pubmed
16039137
uniprot
proteins
pubmed
16612331
uniprot
proteins
pubmed
18272536
uniprot
proteins
sequence_length
345
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9NRA1}. Secreted {ECO:0000250|UniProtKB:Q9NRA1}. Nucleus {ECO:0000250|UniProtKB:Q9NRA1}. Cytoplasmic granule {ECO:0000250|UniProtKB:Q9NRA1}. Cell membrane {ECO:0000250|UniProtKB:Q9NRA1}. Note=Sumoylated form is predominant in the nucleus. Stored in alpha granules in platelets. {ECO:0000250|UniProtKB:Q9NRA1}.
uniprot
proteins