SMC2
entrez
10592
canonical
uniprot
O95347
canonical
ensembl
ENSG00000136824
resolver
ensp
ENSP00000286398
resolver
ensp
ENSP00000363919
resolver
ensp
ENSP00000363925
resolver
ensp
ENSP00000556101
resolver
ensp
ENSP00000556102
resolver
ensp
ENSP00000596229
resolver
ensp
ENSP00000596232
resolver
ensp
ENSP00000626365
resolver
ensp
ENSP00000626366
resolver
ensp
ENSP00000721320
resolver
ensp
ENSP00000734247
resolver
ensp
ENSP00000734248
resolver
ensp
ENSP00000734252
resolver
genesymbol
SMC2
resolver
genesymbol_syn
CAPE
resolver
genesymbol_syn
SMC2L1
resolver
hgnc
HGNC:14011
resolver
uniprot
A8K984
resolver
uniprot
B3KMB1
resolver
uniprot
B7ZLZ7
resolver
uniprot
Q05BV1
resolver
uniprot
Q05D74
resolver
uniprot
Q6IEE0
resolver
uniprot
Q6IPS5
resolver
uniprot
Q7Z2X1
resolver
uniprot
Q9P1P2
resolver
uniprot_entry
A8K984_HUMAN
resolver
uniprot_entry
B3KMB1_HUMAN
resolver
uniprot_entry
B7ZLZ7_HUMAN
resolver
uniprot_entry
Q05BV1_HUMAN
resolver
uniprot_entry
Q05D74_HUMAN
resolver
uniprot_entry
Q6IPS5_HUMAN
resolver
uniprot_entry
Q7Z2X1_HUMAN
resolver
uniprot_entry
SMC2_HUMAN
resolver
uniprot_sec
Q6IEE0
resolver
uniprot_sec
Q9P1P2
resolver
amino_acid_sequence
MHIKSIILEGFKSYAQRTEVNGFDPLFNAITGLNGSGKSNILDSICFLLGISNLSQVRASNLQDLVYKNGQAGITKASVSITFDNSDKKQSPLGFEVHDEITVTRQVVIGGRNKYLINGVNANNTRVQDLFCSVGLNVNNPHFLIMQGRITKVLNMKPPEILSMIEEAAGTRMYEYKKIAAQKTIEKKEAKLKEIKTILEEEITPTIQKLKEERSSYLEYQKVMREIEHLSRLYIAYQFLLAEDTKVRSAEELKEMQDKVIKLQEELSENDKKIKALNHEIEELEKRKDKETGGILRSLEDALAEAQRVNTKSQSAFDLKKKNLACEESKRKELEKNMVEDSKTLAAKEKEVKKITDGLHALQEASNKDAEALAAAQQHFNAVSAGLSSNEDGAEATLAGQMMACKNDISKAQTEAKQAQMKLKHAQQELKNKQAEVKKMDSGYRKDQEALEAVKRLKEKLEAEMKKLNYEENKEESLLEKRRQLSRDIGRLKETYEALLARFPNLRFAYKDPEKNWNRNCVKGLVASLISVKDTSATTALELVAGERLYNVVVDTEVTGKKLLERGELKRRYTIIPLNKISARCIAPETLRVAQNLVGPDNVHVALSLVEYKPELQKAMEFVFGTTFVCDNMDNAKKVAFDKRIMTRTVTLGGDVFDPHGTLSGGARSQAASILTKFQELKDVQDELRIKENELRALEEELAGLKNTAEKYRQLKQQWEMKTEEADLLQTKLQQSSYHKQQEELDALKKTIEESEETLKNTKEIQRKAEEKYEVLENKMKNAEAERERELKDAQKKLDCAKTKADASSKKMKEKQQEVEAITLELEELKREHTSYKQQLEAVNEAIKSYESQIEVMAAEVAKNKESVNKAQEEVTKQKEVITAQDTVIKAKYAEVAKHKEQNNDSQLKIKELDHNISKHKREAEDGAAKVSKMLKDYDWINAERHLFGQPNSAYDFKTNNPKEAGQRLQKLQEMKEKLGRNVNMRAMNVLTEAEERYNDLMKKKRIVENDKSKILTTIEDLDQKKNQALNIAWQKVNKDFGSIFSTLLPGANAMLAPPEGQTVLDGLEFKVALGNTWKENLTELSGGQRSLVALSLILSMLLFKPAPIYILDEVDAALDLSHTQNIGQMLRTHFTHSQFIVVSLKEGMFNNANVLFKTKFVDGVSTVARFTQCQNGKISKEAKSKAKPPKGAHVEV
uniprot
proteins
function
FUNCTION: Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. {ECO:0000269|PubMed:11136719}.
uniprot
proteins
mass_dalton
135656
uniprot
proteins
protein_family
SMC family
uniprot
proteins
protein_family
SMC2 subfamily
uniprot
proteins
pubmed
10958694
uniprot
proteins
pubmed
11136719
uniprot
proteins
pubmed
14660695
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23728299
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
9789013
uniprot
proteins
sequence_length
1197
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10958694}. Cytoplasm {ECO:0000269|PubMed:10958694}. Chromosome {ECO:0000269|PubMed:10958694}. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDC2, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
uniprot
proteins