Aldh3b1
entrez
309147
canonical
uniprot
Q5XI42
canonical
ensembl
ENSRNOG00000017512
resolver
ensembl
ENSRNOG00055021356
resolver
ensembl
ENSRNOG00060032624
resolver
ensembl
ENSRNOG00065032129
resolver
ensp
ENSRNOP00000023789
resolver
ensp
ENSRNOP00055029666
resolver
ensp
ENSRNOP00060046688
resolver
ensp
ENSRNOP00065045509
resolver
enst
ENSRNOT00055036493
resolver
enst
ENSRNOT00060056521
resolver
enst
ENSRNOT00065055319
resolver
genesymbol
Aldh3b1
resolver
uniprot_entry
AL3B1_RAT
resolver
amino_acid_sequence
MDSFEDKLQQLREAFNAGRTRSAEFRAAQLQGLSHFLRDNKQQLQEALAQDLHKSAFESEVSEIAISQAEVDLALRNLRSWMKDEKVSKNLATQLDSAFIRKEPFGLVLIIVPWNYPLNLTLVPLVGAIAAGNCVVLKPSEISKATEKILAEVLPRYLDQSCFAVVLGGPQETGQLLEHRFDYIFFTGNTYVGKIVMAAAAKHLTPITLELGGKNPCYVDDNCDPQTVANRVAWFRYFNAGQTCVAPDYVLCSQEMQERLVPALQNAITRFYGDNPQTSPNLGRIINQKHFERLQGLLGCGRVAIGGQSDEGERYIAPTVLVDVQETEPVMQEEIFGPILPLVTVTNLDEAIEFINRREKPLALYAFSKRSQVIKQVLARTSSGGFCGNDGFMHMTLSSLPFGGVGTSGMGRYHGKFSFDTFSNQRACLLRSPGMEKINDLRYPPYTSRNLRVLLVAMEKRCCSCTLL
uniprot
proteins
ec_number
1.2.1.28
uniprot
proteins
ec_number
1.2.1.48
uniprot
proteins
ec_number
1.2.1.5
uniprot
proteins
ec_number
1.2.1.7
uniprot
proteins
function
FUNCTION: Oxidizes medium and long chain saturated and unsaturated fatty aldehydes generated in the plasma membrane into non-toxic fatty acids. May have a protective role against the cytotoxicity induced by lipid peroxidation. Short-chain fatty aldehydes are not good substrates. Can use both NADP(+) and NAD(+) as electron acceptor in vitro, however in vivo preference will depend on their tissue levels. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. Able to metabolize aromatic aldehydes such as benzaldehyde to their acid form. {ECO:0000250|UniProtKB:P43353}.
uniprot
proteins
mass_dalton
52147
uniprot
proteins
pathway_participation
PATHWAY: Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
uniprot
proteins
post_translational_modification
PTM: Dually lipidated in the C-terminus; prenylation occurs prior to, and is a prerequisite for palmitoylation. It is also required for activity towards long-chain substrates. {ECO:0000250|UniProtKB:Q80VQ0}.
uniprot
proteins
protein_family
Aldehyde dehydrogenase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
468
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Primarily in the plasma membrane as well as in some punctate structures in the cytoplasm. {ECO:0000250}.
uniprot
proteins