Fcho1
entrez
74015
canonical
uniprot
Q8K285
canonical
ensembl
ENSMUSG00000070000
resolver
ensp
ENSMUSP00000091151
resolver
ensp
ENSMUSP00000117606
resolver
ensp
ENSMUSP00000317860
resolver
ensp
ENSMUSP00000317883
resolver
ensp
ENSMUSP00000317903
resolver
ensp
ENSMUSP00000330313
resolver
enst
ENSMUST00000093444
resolver
enst
ENSMUST00000146100
resolver
genesymbol
Fcho1
resolver
uniprot
D3Z3Q5
resolver
uniprot_entry
FCHO1_MOUSE
resolver
uniprot_sec
D3Z3Q5
resolver
amino_acid_sequence
MSYFGEHFWGDKNHGFEVLYHCVKQGPVATKELADFIRERANIEETYSKAMAKLSKLASNGTPMGTFAPLWEVFRVSSDKLALCHLELTRKLHDLLKDVLRYGEEQLKTHKKCKEEVLGTVDAVQMLSGVGQLLPKSRENYLSRCMDLERLRRENTSQKEMDKAETKSKKAADSLRRSVDKYNSARADFEIKMLDSALRFQAMEEAHLQHMKALLGSYAHSVEDTHVQIGQVHEEFKQNVENVTVDMLLRKFAESKGTGREKPGPLDFDAYSSAALQEAMKRLRGAKAFRLPGLSRREPRASVDFLESDSGVPPEVDDEGFTVRPDISQNNGAEPPRFSSSDSDFDDEEPRKFYVHIKPAPTRAVACSSEAAAAQLRATAGSLILPPGPGGTMKRHSSRDTSGKPQRPRSAPRTGSCAEKPLASEEPLSKSLFGPPLESAFDHDDFTGSSSLGFTSSPSPFSSSSPENVEDSGLDSPSHAAPGPSPESWVPRPGTPQSPPTCRAQHPEPRGLMPRAPSPGPWGPEGGADSLTPADPTREGLAATLRRPRSRKVSCPLTRSNGDLCRSLSPSPLGSSAPTIPPDRPSFSTQMGHGISRGPSPVVLGSQDALPVATAFTEYVHAYFRGHSPSCLARVTGELTMTFPAGIVRVFSGTPPPPVLSFRLVNTAPVEHFQPNADLIFSDPSQSDPETKDFWLNMAALTEALQHQAEQNPTASYYNLVLLRYQFSRPGPESVPLQMSAHWQCGPTLTRVSVEYSYRAGATAVSTPLTNVQILLPVGEPVTSVRLQPAATWNTEEKRFTWKLPDVCEAGGSGHLSASWQPQSGPSTPSPVAAQFTSEGATLSGLDLELLGGGYRMSLVKRRFATGMYLVSC
uniprot
proteins
function
FUNCTION: Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell proliferation and activation. Affects TCR clustering upon receptor triggering and modulates its internalization, playing a role in TCR-dependent T-cell activation. {ECO:0000250|UniProtKB:O14526}.
uniprot
proteins
mass_dalton
95122
uniprot
proteins
protein_family
FCHO family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21762413
uniprot
proteins
pubmed
22484487
uniprot
proteins
sequence_length
873
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:O14526}; Peripheral membrane protein {ECO:0000250|UniProtKB:O14526}; Cytoplasmic side {ECO:0000250|UniProtKB:O14526}. Note=Associated with forming but not mature clathrin-coated vesicles. The recruitment to coated-pits precede the one of clathrin and the adaptor protein complex AP-2. According to it may also dynamically associate with Golgi/TGN membranes. {ECO:0000250|UniProtKB:O14526}.
uniprot
proteins