Lgmn
entrez
63865
canonical
uniprot
Q9R0J8
canonical
ensembl
ENSRNOG00000007089
resolver
ensp
ENSRNOP00000010101
resolver
enst
ENSRNOT00000010101
resolver
genesymbol
Lgmn
resolver
genesymbol_syn
Prsc1
resolver
uniprot
A0ACM8Q6F0
resolver
uniprot
A6JEK1
resolver
uniprot
Q5PPG2
resolver
uniprot
Q9JLN3
resolver
uniprot_entry
A0ACM8Q6F0_RAT
resolver
uniprot_entry
A6JEK1_RAT
resolver
uniprot_entry
LGMN_RAT
resolver
uniprot_sec
Q5PPG2
resolver
uniprot_sec
Q9JLN3
resolver
amino_acid_sequence
MTWRVAVLLSLVLGAGAVHIGVDDPEDGGKHWVVIVAGSNGWYNYRHQADACHAYQIIHRNGIPDEQIIVMMYDDIANNEENPTPGVVINRPNGTDVYKGVPKDYTGEDVTPENFLAVLRGDEEAVKGKGSGKVLKSGPRDHVFVYFTDHGATGILVFPNEDLHVKDLNKTIRYMYEHKMYQKMVFYIEACESGSMMNHLPDDIDVYATTAANPNESSYACYYDEERSTYLGDWYSVNWMEDSDVEDLTKETLHKQYHLVKSHTNTSHVMQYGNKSISTMKVMQFQGMKHRASSPISLPPVTHLDLTPSPDVPLTILKRKLLRTNNMKESQVLVGQIQHLLDARHIIEKSVQKIVSLLAGFGETAQKHLSERAMLTAHDCHQEAVTHFRTHCFNWHSVTYEHALRYLYVLANLCEKPYPIDRIKMAMDKVCLSHY
uniprot
proteins
ec_number
3.4.22.34
uniprot
proteins
function
FUNCTION: Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. Involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system (By similarity). Also involved in MHC class I antigen presentation in cross-presenting dendritic cells by mediating cleavage and maturation of Perforin-2 (MPEG1), thereby promoting antigen translocation in the cytosol. Required for normal lysosomal protein degradation in renal proximal tubules. Required for normal degradation of internalized EGFR. Plays a role in the regulation of cell proliferation via its role in EGFR degradation (By similarity). {ECO:0000250|UniProtKB:O89017, ECO:0000250|UniProtKB:Q99538}.
uniprot
proteins
mass_dalton
49466
uniprot
proteins
post_translational_modification
PTM: Activated by autocatalytic processing at pH 4. {ECO:0000250|UniProtKB:Q99538}.
uniprot
proteins
protein_family
Peptidase C13 family
uniprot
proteins
pubmed
9742219
uniprot
proteins
sequence_length
435
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:9742219}.
uniprot
proteins