Dnajb9
entrez
27362
canonical
uniprot
Q9QYI6
canonical
ensembl
ENSMUSG00000014905
resolver
ensp
ENSMUSP00000015049
resolver
enst
ENSMUST00000015049
resolver
genesymbol
Dnajb9
resolver
uniprot
Q5D0C3
resolver
uniprot
Q9DAW1
resolver
uniprot_entry
DNJB9_MOUSE
resolver
uniprot_sec
Q5D0C3
resolver
uniprot_sec
Q9DAW1
resolver
amino_acid_sequence
MATPQSVFVFAICILMITELILASKSYYDILGVPKSASERQIKKAFHKLAMKYHPDKNKSPDAEAKFREIAEAYETLSDANSRKEYDTIGHSAFTNGKGQRGNGSPFEQSFNFNFDDLFKDFNFFGQNQNTRSKKHFENHFHTRQDGSSRQRHHFQEFSFGGGLFDDMFEDMEKMFSFSGFDTTNRHTVQTENRFHGSSKHCRTVTQRRGNMVTTYTDCSGQ
uniprot
proteins
function
FUNCTION: Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins (PubMed:11836248). In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity). Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins (PubMed:22267725). Required for survival of B-cell progenitors and normal antibody production (PubMed:25222125). {ECO:0000250|UniProtKB:G3H0N9, ECO:0000269|PubMed:11836248, ECO:0000269|PubMed:22267725, ECO:0000269|PubMed:25222125}.
uniprot
proteins
mass_dalton
25616
uniprot
proteins
mutagenesis
MUTAGEN 54; /note="H->Q: Abolishes ability to stimulate ATPase activity of HSPA5/BiP."; /evidence="ECO:0000269|PubMed:11836248
uniprot
proteins
post_translational_modification
PTM: Not N-glycosylated. {ECO:0000269|PubMed:11836248}.
uniprot
proteins
pubmed
11147971
uniprot
proteins
pubmed
11836248
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22267725
uniprot
proteins
pubmed
24336520
uniprot
proteins
pubmed
25222125
uniprot
proteins
pubmed
27546788
uniprot
proteins
sequence_length
222
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:22267725, ECO:0000305|PubMed:11836248}.
uniprot
proteins