Fbxl3
entrez
50789
canonical
uniprot
Q8C4V4
canonical
ensembl
ENSMUSG00000022124
resolver
ensp
ENSMUSP00000022720
resolver
ensp
ENSMUSP00000115843
resolver
ensp
ENSMUSP00000116044
resolver
ensp
ENSMUSP00000177008
resolver
ensp
ENSMUSP00000177012
resolver
ensp
ENSMUSP00000177015
resolver
genesymbol
Fbxl3
resolver
genesymbol_syn
Afh
resolver
genesymbol_syn
Fbl3a
resolver
genesymbol_syn
Fbxl3a
resolver
genesymbol_syn
Ovtm
resolver
uniprot
Q5PRF6
resolver
uniprot
Q80V32
resolver
uniprot
Q8BNS3
resolver
uniprot
Q8K1W0
resolver
uniprot
Q9QXW1
resolver
uniprot_entry
FBXL3_MOUSE
resolver
uniprot_entry
Q5PRF6_MOUSE
resolver
uniprot_entry
Q8BNS3_MOUSE
resolver
uniprot_sec
Q80V32
resolver
uniprot_sec
Q8K1W0
resolver
uniprot_sec
Q9QXW1
resolver
amino_acid_sequence
MKRGGRDSDQDSAEEGTAEKPKRPRTTQERSQPCDWGNLLQDIVLHVFKYLPLLDRAHASQVCRNWNQVFHMPDLWRCFEFELNQPATSYLKATHPELIKQIIKRHSNHLQYVSFKVDSSKESAEAACDILSQLVNCSLKTLGLISTARPSFMDLPKSHFISALTVVFVNSKSLSSLKIDDTPVDDPSLKVLVANNSDTLKLLKMSSCPHVSPAGILCVADQCHGLRELALNYHLLSDELLLALSSEKHVRLEHLRIDVVSENPGQTHFHTIQKSSWDAFIKHSPKVNLVMYFFLYEEEFDPFFRYEIPATHLYFGRSVSKDVLGRVGMTCPRLVELVVCANGLRPLDEELIRIAERCKNLSAIGLGECEVSCSAFVEFVKMCGGRLSQLSIMEEVLIPDQKYSLEQIHWEVSKHLGRVWFPDMMPTW
uniprot
proteins
function
FUNCTION: Substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex involved in circadian rhythm function. Plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The SCF(FBXL3) complex mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2. Activity of the SCF(FBXL3) complex is counteracted by the SCF(FBXL21) complex. {ECO:0000269|PubMed:17462724, ECO:0000269|PubMed:17463252, ECO:0000269|PubMed:18953409, ECO:0000269|PubMed:23452855, ECO:0000269|PubMed:23452856, ECO:0000269|PubMed:23616524, ECO:0000269|PubMed:26776516}.
uniprot
proteins
mass_dalton
48682
uniprot
proteins
mutagenesis
MUTAGEN 22..25; /note="KRPR->AAAA: Induces relocalization to the cytosol."; /evidence="ECO:0000269|PubMed:23452856"; MUTAGEN 143; /note="G->E: No effect."; /evidence="ECO:0000269|PubMed:23452855"; MUTAGEN 358; /note="C->S: In after-hour (afh) mutant; lengthening in circadian periodicity."; /evidence="ECO:0000269|PubMed:17463252"; MUTAGEN 364; /note="I->T: In overtime (ovtm) mutant; loss of function, lengthening of the circadian periodiocity and Cry1 stabilization of protein levels."; /evidence="ECO:0000269|PubMed:17462724
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Undergoes autophagy-mediated degradation in the liver in a time-dependent manner. {ECO:0000269|PubMed:29937374}.
uniprot
proteins
pubmed
10531037
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17462724
uniprot
proteins
pubmed
17463252
uniprot
proteins
pubmed
18953409
uniprot
proteins
pubmed
23452855
uniprot
proteins
pubmed
23452856
uniprot
proteins
pubmed
23616524
uniprot
proteins
pubmed
26776516
uniprot
proteins
pubmed
29937374
uniprot
proteins
pubmed
30500822
uniprot
proteins
sequence_length
428
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26776516}. Cytoplasm. Note=Predominantly nuclear.
uniprot
proteins