Kdm7a
entrez
338523
canonical
uniprot
Q3UWM4
canonical
ensembl
ENSMUSG00000042599
resolver
ensp
ENSMUSP00000002305
resolver
enst
ENSMUST00000002305
resolver
genesymbol
Kdm7a
resolver
genesymbol_syn
Jhdm1d
resolver
genesymbol_syn
Kdm7
resolver
genesymbol_syn
Kiaa1718
resolver
uniprot
A6H6E5
resolver
uniprot
Q3UWN8
resolver
uniprot
Q6ZPJ5
resolver
uniprot
Q8C969
resolver
uniprot
Q8C9E0
resolver
uniprot
Q91VX8
resolver
uniprot_entry
KDM7A_MOUSE
resolver
uniprot_sec
A6H6E5
resolver
uniprot_sec
Q3UWN8
resolver
uniprot_sec
Q6ZPJ5
resolver
uniprot_sec
Q8C969
resolver
uniprot_sec
Q8C9E0
resolver
uniprot_sec
Q91VX8
resolver
amino_acid_sequence
MAGAAAAVAAGAAAGAAAAAGSVSAPGRASAPPPPPPVYCVCRQPYDVNRFMIECDVCKDWFHGSCVGVEEHHAVDIDLYHCPDCAALHGSSLMKKRRNWHRHDYTEVDDGSKPVQAGTRAFVKELRSRVFPSADEIIVKMHGSQLTQRYLEKHGFDVPIMVPKLDDLGLRLPSPAFSVMDVERYVGGDKVIDVIDVARQADSKMTLHNYVKYFMNPDRPKVLNVISLEFSDTKMSELVEVPDIARKLSWVENYWPDDSVFPKPFVQKYCLMGVQDSYTDFHIDFGGTSVWYHVLWGEKIFYLIKPTNENLALYESWSSSVTQSEVFFGDKVDKCYKCVVKQGHTLFVPTGWIHAVLTSQDCMAFGGNFLHNLNIGMQLRCYEMEKRLKTPDLFKFPFFEAICWFVAKSLLETLKELKEDGFQPQSYLVQGVKALHTALKLWMKKELVSEHAFEIPDNVRPGHLIKELSKVIRAIEEENGKPVKSQGIPSVCPVSRPSNEASPPYHSRRKMRKLRDHNVRTPSNLDILELHTREVLKRLEMCPWEEDLLSSKLNGKFNKHLQPSSTVPEWRAKDNDLRLLLTNGRIIKDERQLFADRSLYTADSENEEDKKPTQNANMKTEQSSGREEAESQGSPKPLNRIFTSVRSELRSRPSEYSDGSDSEDSGPDCTALKINFATEDSESSGDEKKHEITSHFKEESDIVRNLLQKSQKPSRQEIPVKRECPTSTSTEEEAIQGMLSMAGLHYSSCLQRQIQSTDCSGEKNSLQDPSSCHGSNPEFRQLYRCNKPVEFGYHAKTEDQDLMTSSWNKQFDRTSRFNAQDLSRSQKHIKKESSSEINQKAQSRHCVDSNSSSIQNGKYTLNPSLVSCQISNGSLSPERPIGETSFSMPLHPTKRPASNPPPISNQATKGKRPKKGMATAKQRLGKILKLNRNGHARFFV
uniprot
proteins
ec_number
1.14.11.65
uniprot
proteins
function
FUNCTION: Histone demethylase required for brain development. Specifically demethylates dimethylated 'Lys-9', 'Lys-27' and 'Lys-36' (H3K9me2, H3K27me2, H3K36me2, respectively) of histone H3 and monomethylated histone H4 'Lys-20' residue (H4K20Me1), thereby playing a central role in histone code. Specifically binds trimethylated 'Lys-4' of histone H3 (H3K4me3), affecting histone demethylase specificity: in presence of H3K4me3, it has no demethylase activity toward H3K9me2, while it has high activity toward H3K27me2. Demethylates H3K9me2 in absence of H3K4me3. Has activity toward H4K20Me1 only when nucleosome is used as a substrate and when not histone octamer is used as substrate. {ECO:0000250|UniProtKB:Q6ZMT4, ECO:0000269|PubMed:20194436}.
uniprot
proteins
mass_dalton
106075
uniprot
proteins
mutagenesis
MUTAGEN 39..86; /note="Missing: Has no effect on enzymatic activity."; /evidence="ECO:0000269|PubMed:20194436"; MUTAGEN 230..386; /note="Missing: Abolishes enzymatic activity."; /evidence="ECO:0000269|PubMed:20194436"; MUTAGEN 282; /note="H->A: Abolishes enzymatic activity."; /evidence="ECO:0000269|PubMed:20194436
uniprot
proteins
protein_family
JHDM1 histone demethylase family
uniprot
proteins
protein_family
JHDM1D subfamily
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20194436
uniprot
proteins
sequence_length
940
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins