Glra2
entrez
24397
canonical
uniprot
P22771
canonical
ensembl
ENSRNOG00000003313
resolver
ensp
ENSRNOP00000004443
resolver
ensp
ENSRNOP00000091317
resolver
enst
ENSRNOT00000004443
resolver
enst
ENSRNOT00000111367
resolver
genesymbol
Glra2
resolver
uniprot
A0A0G2JSH7
resolver
uniprot
A0A8I6GJI2
resolver
uniprot
Q91W28
resolver
uniprot_entry
A0A0G2JSH7_RAT
resolver
uniprot_entry
A0A8I6GJI2_RAT
resolver
uniprot_entry
GLRA2_RAT
resolver
uniprot_sec
Q91W28
resolver
activity_regulation
ACTIVITY REGULATION: Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine (PubMed:2176511). Inhibited by strychnine (PubMed:2176511). Inhibited by picrotoxin (By similarity). {ECO:0000250|UniProtKB:P23416, ECO:0000269|PubMed:2176511}.
uniprot
proteins
amino_acid_sequence
MNRQLVNILTALFAFFLGTNHFREAFCKDHDSRSGKHPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFEYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDADAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK
uniprot
proteins
function
FUNCTION: Subunit of heteromeric glycine-gated chloride channels (PubMed:2176511). Plays a role in synaptic plasticity. Contributes to the generation of inhibitory postsynaptic currents, and is involved in the down-regulation of neuronal excitability. Plays a role in cellular responses to ethanol. {ECO:0000250|UniProtKB:P23416, ECO:0000269|PubMed:2176511}.
uniprot
proteins
mass_dalton
52053
uniprot
proteins
protein_family
GLRA2 sub-subfamily
uniprot
proteins
protein_family
Glycine receptor (TC 1.A.9.3) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
1645300
uniprot
proteins
pubmed
1707830
uniprot
proteins
pubmed
2176511
uniprot
proteins
sequence_length
452
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q7TNC8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7TNC8}. Synapse {ECO:0000250|UniProtKB:Q7TNC8}. Cell membrane {ECO:0000269|PubMed:2176511}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23415}. Cell projection {ECO:0000250|UniProtKB:Q7TNC8}.
uniprot
proteins
transmembrane_region
TRANSMEM 257..278; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P23415"; TRANSMEM 284..304; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P23415"; TRANSMEM 316..336; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P23415"; TRANSMEM 421..441; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P23415
uniprot
proteins