Cops3
entrez
26572
canonical
uniprot
O88543
canonical
ensembl
ENSMUSG00000019373
resolver
ensp
ENSMUSP00000019517
resolver
enst
ENSMUST00000019517
resolver
genesymbol
Cops3
resolver
genesymbol_syn
Csn3
resolver
uniprot
Q3UQL2
resolver
uniprot_entry
CSN3_MOUSE
resolver
uniprot_entry
Q3UQL2_MOUSE
resolver
amino_acid_sequence
MASALEQFVNSVRQLSAQGQMTQLCELINKSGELLAKNLSHLDTVLGALDVQEHSLGVLAVLFVKFSMPSVPDFETLFSQVQLFISTCNGEHIRYATDTFAGLCHQLTNALVERKQPLRGIGILKQAIDKMQMNTNQLTSVHADLCQLCLLAKCFKPALPYLDVDMMDICKENGAYDAKHFLCYYYYGGMIYTGLKNFERALYFYEQAITTPAMAVSHIMLESYKKYILVSLILLGKVQQLPKYTSQIVGRFIKPLSNAYHELAQVYSTNNPSELRNLVSKHSETFTRDNNMGLVKQCLSSLYKKNIQRLTKTFLTLSLQDMASRVQLSGPQEAEKYVLHMIEDGEIFASINQKDGMVSFHDNPEKYNNPAMLHNIDQEMLKCIELDERLKAMDQEITVNPQFVQKSMGSQEDDSGNKPSSYS
uniprot
proteins
function
FUNCTION: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases (By similarity). CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). Essential to maintain the survival of epiblast cells and thus the development of the postimplantation embryo (PubMed:12972600). Mediates the interaction between the desmosome and COP9 signalosome complex (CSN) protein complex (By similarity). As a result of this interaction, promotes keratinocyte differentiation via deneddylation of EGFR resulting in a reduction in EGFR protein stabilization and translocation away from the cell membrane (By similarity). {ECO:0000250|UniProtKB:Q9UNS2, ECO:0000269|PubMed:12972600}.
uniprot
proteins
mass_dalton
47832
uniprot
proteins
protein_family
CSN3 family
uniprot
proteins
pubmed
12972600
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9707402
uniprot
proteins
sequence_length
423
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UNS2}. Nucleus {ECO:0000250|UniProtKB:Q9UNS2}. Cell junction {ECO:0000250|UniProtKB:Q9UNS2}.
uniprot
proteins