TRPC5
entrez
7224
canonical
uniprot
Q9UL62
canonical
ensembl
ENSG00000072315
resolver
ensp
ENSP00000262839
resolver
enst
ENST00000262839
resolver
genesymbol
TRPC5
resolver
genesymbol_syn
TRP5
resolver
hgnc
HGNC:12337
resolver
uniprot
B2RP53
resolver
uniprot
O75233
resolver
uniprot
Q5JXY8
resolver
uniprot
Q9Y514
resolver
uniprot_entry
TRPC5_HUMAN
resolver
uniprot_sec
B2RP53
resolver
uniprot_sec
O75233
resolver
uniprot_sec
Q5JXY8
resolver
uniprot_sec
Q9Y514
resolver
activity_regulation
ACTIVITY REGULATION: Activated by G protein-coupled receptors via direct interaction with GTP-bound GNAI3, which increases the channel sensitivity to phosphatidylinositol bisphosphate (PubMed:37137991). May be activated by intracellular calcium store depletion. Calcium channel activity is enhanced by MYLK, that promotes its subcellular localization at the plasma membrane. {ECO:0000269|PubMed:16284075, ECO:0000269|PubMed:37137991}.
uniprot
proteins
amino_acid_sequence
MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRRPSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRRNLRSFTERNADSLIQNQHYQEVIRNLVKRYVAAMIRNSKTHEGLTEENFKELKQDISSFRYEVLDLLGNRKHPRSFSTSSTELSQRDDNNDGSGGARAKSKSVSFNLGCKKKTCHGPPLIRTMPRSSGAQGKSKAESSSKRSFMGPSLKKLGLLFSKFNGHMSEPSSEPMYTISDGIVQQHCMWQDIRYSQMEKGKAEACSQSEINLSEVELGEVQGAAQSSECPLACSSSLHCASSICSSNSKLLDSSEDVFETWGEACDLLMHKWGDGQEEQVTTRL
uniprot
proteins
disease_involvement
DISEASE: Note=Loss-of-function variants in TRPC5 may be involved in a mental disorder characterized by maladaptive behavior, anxiety, autism, postpartum depression, extreme food-seeking and hoarding behavior, hyperphagia and obesity. {ECO:0000269|PubMed:38959890}.
uniprot
proteins
function
FUNCTION: Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:16284075, PubMed:38959890, PubMed:37137991). Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (By similarity). Acts on distinct neuronal populations in the hypothalamus to regulate innate behaviors including feeding, anxiety (flight/fight/fear), socialization, and maternal care (By similarity). {ECO:0000250|UniProtKB:Q9QX29, ECO:0000269|PubMed:16284075, ECO:0000269|PubMed:37137991, ECO:0000269|PubMed:38959890}.
uniprot
proteins
mass_dalton
111412
uniprot
proteins
protein_family
STrpC subfamily
uniprot
proteins
protein_family
TRPC5 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
pubmed
10493832
uniprot
proteins
pubmed
12032305
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15757897
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
15895247
uniprot
proteins
pubmed
16284075
uniprot
proteins
pubmed
16883570
uniprot
proteins
pubmed
17850865
uniprot
proteins
pubmed
20164195
uniprot
proteins
pubmed
23033978
uniprot
proteins
pubmed
32110987
uniprot
proteins
pubmed
37137991
uniprot
proteins
pubmed
38959890
uniprot
proteins
pubmed
9687496
uniprot
proteins
sequence_length
973
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16284075, ECO:0000269|PubMed:38959890}; Multi-pass membrane protein {ECO:0000269|PubMed:37137991}.
uniprot
proteins
transmembrane_region
TRANSMEM 364..384; /note="Helical; Name=S1"; /evidence="ECO:0000269|PubMed:37137991, ECO:0007744|PDB:7X6C, ECO:0007744|PDB:7X6I, ECO:0007744|PDB:8GVW, ECO:0007744|PDB:8GVX"; TRANSMEM 405..419; /note="Helical; Name=S2"; /evidence="ECO:0000269|PubMed:37137991, ECO:0007744|PDB:7X6C, ECO:0007744|PDB:7X6I, ECO:0007744|PDB:8GVW, ECO:0007744|PDB:8GVX"; TRANSMEM 434..454; /note="Helical; Name=S3"; /evidence="ECO:0000269|PubMed:37137991, ECO:0007744|PDB:7X6C, ECO:0007744|PDB:7X6I, ECO:0007744|PDB:8GVW, ECO:0007744|PDB:8GVX"; TRANSMEM 477..497; /note="Helical; Name=S4"; /evidence="ECO:0000269|PubMed:37137991, ECO:0007744|PDB:7X6C, ECO:0007744|PDB:7X6I, ECO:0007744|PDB:8GVW, ECO:0007744|PDB:8GVX"; TRANSMEM 513..535; /note="Helical; Name=S5"; /evidence="ECO:0000269|PubMed:37137991, ECO:0007744|PDB:7X6C, ECO:0007744|PDB:7X6I, ECO:0007744|PDB:8GVW, ECO:0007744|PDB:8GVX"; TRANSMEM 604..624; /note="Helical; Name=S6"; /evidence="ECO:0000269|PubMed:37137991, ECO:0007744|PDB:7X6C, ECO:0007744|PDB:7X6I, ECO:0007744|PDB:8GVW, ECO:0007744|PDB:8GVX
uniprot
proteins