Clk3
entrez
171305
canonical
uniprot
Q63117
canonical
ensembl
ENSRNOG00000030126
resolver
ensp
ENSRNOP00000061691
resolver
enst
ENSRNOT00000068108
resolver
genesymbol
Clk3
resolver
uniprot
A0A8L2QUB6
resolver
uniprot
Q6IRK2
resolver
uniprot_entry
A0A8L2QUB6_RAT
resolver
uniprot_entry
CLK3_RAT
resolver
uniprot_sec
Q6IRK2
resolver
activity_regulation
ACTIVITY REGULATION: Leucettine L41 inhibits its kinase activity and affects the regulation of alternative splicing mediated by phosphorylation of SR proteins. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRIPYQRRYREHRDSDTYRCEERSPSFGEDCYGSSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHSSRNPSR
uniprot
proteins
ec_number
2.7.12.1
uniprot
proteins
function
FUNCTION: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
58485
uniprot
proteins
post_translational_modification
PTM: Autophosphorylates on all three types of residues.
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Lammer subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8679717
uniprot
proteins
sequence_length
490
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250}.
uniprot
proteins