Kcnmb1
entrez
16533
canonical
uniprot
Q8CAE3
canonical
ensembl
ENSMUSG00000020155
resolver
ensp
ENSMUSP00000020362
resolver
ensp
ENSMUSP00000345053
resolver
enst
ENSMUST00000020362
resolver
genesymbol
Kcnmb1
resolver
uniprot
O35336
resolver
uniprot
O35645
resolver
uniprot
Q5SQK1
resolver
uniprot_entry
KCMB1_MOUSE
resolver
uniprot_entry
Q5SQK1_MOUSE
resolver
uniprot_sec
O35336
resolver
uniprot_sec
O35645
resolver
amino_acid_sequence
MGKKLVMAQKRGETRALCLGVAMVVCAAITYYVLGTTVLPLYQKSVWTQESICHLIETNIKDQEELEGKKVPQYPCLWVNVSAVGRWAMLYHTEDTRDQNQQCSYIPRNLDNYQTALADVKKVRANFYKHHEFYCLSAPQVNETSVVYQRLYGPQVLLFSFFWPTFLLTGGLLLIAMVKLNRSLSILAAQK
uniprot
proteins
function
FUNCTION: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate. {ECO:0000269|PubMed:11057658}.
uniprot
proteins
mass_dalton
21846
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250}.
uniprot
proteins
protein_family
KCNMB (TC 8.A.14.1) family
uniprot
proteins
protein_family
KCNMB1 subfamily
uniprot
proteins
pubmed
11057658
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
9888999
uniprot
proteins
sequence_length
191
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 19..39; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 156..176; /note="Helical; Name=2"; /evidence="ECO:0000255
uniprot
proteins