SHB
entrez
6461
canonical
uniprot
Q15464
canonical
ensembl
ENSG00000107338
resolver
ensembl
ENSG00000255872
resolver
ensp
ENSP00000366936
resolver
genesymbol
SHB
resolver
hgnc
HGNC:10838
resolver
uniprot
B9EGM0
resolver
uniprot
D3DRQ5
resolver
uniprot
Q504U5
resolver
uniprot
Q5VUM8
resolver
uniprot_entry
SHB_HUMAN
resolver
uniprot_sec
B9EGM0
resolver
uniprot_sec
D3DRQ5
resolver
uniprot_sec
Q504U5
resolver
uniprot_sec
Q5VUM8
resolver
amino_acid_sequence
MAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSGSLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGSPHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKVTIADDYSDPFDAKNDLKSKAGKGESAGYMEPYEAQRIMTEFQRQESVRSQHKGIQLYDTPYEPEGQSVDSDSESTVSPRLRESKLPQDDDRPADEYDQPWEWNRVTIPALAAQFNGNEKRQSSPSPSRDRRRQLRAPGGGFKPIKHGSPEFCGILGERVDPAVPLEKQIWYHGAISRGDAENLLRLCKECSYLVRNSQTSKHDYSLSLRSNQGFMHMKLAKTKEKYVLGQNSPPFDSVPEVIHYYTTRKLPIKGAEHLSLLYPVAVRTL
uniprot
proteins
function
FUNCTION: Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. {ECO:0000269|PubMed:10828022, ECO:0000269|PubMed:10837138, ECO:0000269|PubMed:12084069, ECO:0000269|PubMed:12464388, ECO:0000269|PubMed:12520086, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15919073, ECO:0000269|PubMed:8806685, ECO:0000269|PubMed:9484780, ECO:0000269|PubMed:9751119}.
uniprot
proteins
mass_dalton
55042
uniprot
proteins
mutagenesis
MUTAGEN 435; /note="R->K: Loss of interaction with CD3Z. Alters LAT, PLCG1, VAV1 and LCP2 phosphorylation, MAP kinase signaling, Rac1 and JNK activation, intracellular calcium increase, activation of the nuclear factor for activation of T-cells and subsequent interleukin-2 expression which normally occur upon T-cells stimulation."; /evidence="ECO:0000269|PubMed:9484780
uniprot
proteins
post_translational_modification
PTM: Phosphorylated upon PDGFRA, PDGFRB, TCR, IL2 receptor, FGFR1 or VEGFR2 activation. {ECO:0000269|PubMed:10488157}.
uniprot
proteins
pubmed
10488157
uniprot
proteins
pubmed
10828022
uniprot
proteins
pubmed
10837138
uniprot
proteins
pubmed
10964504
uniprot
proteins
pubmed
12084069
uniprot
proteins
pubmed
12181353
uniprot
proteins
pubmed
12200137
uniprot
proteins
pubmed
12464388
uniprot
proteins
pubmed
12520086
uniprot
proteins
pubmed
15026417
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15919073
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
7537362
uniprot
proteins
pubmed
8302579
uniprot
proteins
pubmed
8806685
uniprot
proteins
pubmed
9484780
uniprot
proteins
pubmed
9751119
uniprot
proteins
sequence_length
509
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associates with membrane lipid rafts upon TCR stimulation.
uniprot
proteins