Cd93
entrez
17064
canonical
uniprot
O89103
canonical
ensembl
ENSMUSG00000027435
resolver
ensp
ENSMUSP00000096876
resolver
enst
ENSMUST00000099269
resolver
genesymbol
Cd93
resolver
genesymbol_syn
Aa4
resolver
genesymbol_syn
C1qr1
resolver
genesymbol_syn
C1qrp
resolver
genesymbol_syn
Ly68
resolver
uniprot
A2AVY5
resolver
uniprot
Q3U2X0
resolver
uniprot_entry
C1QR1_MOUSE
resolver
uniprot_sec
A2AVY5
resolver
uniprot_sec
Q3U2X0
resolver
amino_acid_sequence
MAISTGLFLLLGLLGQPWAGAAADSQAVVCEGTACYTAHWGKLSAAEAQHRCNENGGNLATVKSEEEARHVQQALTQLLKTKAPLEAKMGKFWIGLQREKGNCTYHDLPMRGFSWVGGGEDTAYSNWYKASKSSCIFKRCVSLILDLSLTPHPSHLPKWHESPCGTPEAPGNSIEGFLCKFNFKGMCRPLALGGPGRVTYTTPFQATTSSLEAVPFASVANVACGDEAKSETHYFLCNEKTPGIFHWGSSGPLCVSPKFGCSFNNGGCQQDCFEGGDGSFRCGCRPGFRLLDDLVTCASRNPCSSNPCTGGGMCHSVPLSENYTCRCPSGYQLDSSQVHCVDIDECQDSPCAQDCVNTLGSFHCECWVGYQPSGPKEEACEDVDECAAANSPCAQGCINTDGSFYCSCKEGYIVSGEDSTQCEDIDECSDARGNPCDSLCFNTDGSFRCGCPPGWELAPNGVFCSRGTVFSELPARPPQKEDNDDRKESTMPPTEMPSSPSGSKDVSNRAQTTGLFVQSDIPTASVPLEIEIPSEVSDVWFELGTYLPTTSGHSKPTHEDSVSAHSDTDGQNLLLFYILGTVVAISLLLVLALGILIYHKRRAKKEEIKEKKPQNAADSYSWVPERAESQAPENQYSPTPGTDC
uniprot
proteins
function
FUNCTION: Cell surface receptor that plays a role in various physiological processes including inflammation, phagocytosis, and cell adhesion (PubMed:15004139, PubMed:20439917, PubMed:38441970). Plays a role in phagocytosis and enhances the uptake of apoptotic cells and immune complexes by acting as a receptor for defense collagens including surfactant protein A/SFTPA1, C1q, and mannose-binding lectin (MBL2) (PubMed:15004139). Plays a role in the regulation of endothelial cell function and adhesion by activating angiogenesis. Mechanistically, exerts its angiogenic function by associating with beta-dystroglycan, leading to SRC-dependent phosphorylation and subsequent recruitment of CBL. In turn, CBL provides a docking site for downstream signaling components, such as CRKL to enhance cell migration. Participates in angiogenesis also by acting as a receptor for the ECM pan-endothelial glycoprotein multimerin-2/MMRN2 and IGFBP7 ligands. Both ligands play a non-redundant role in CD93-mediated endothelial cell function (By similarity). Acts as a key regulator of endothelial barrier function through modulating VEGFR2 function (PubMed:38441970). {ECO:0000250|UniProtKB:Q9NPY3, ECO:0000269|PubMed:15004139, ECO:0000269|PubMed:20439917, ECO:0000269|PubMed:38441970}.
uniprot
proteins
mass_dalton
69354
uniprot
proteins
post_translational_modification
PTM: N- and O-glycosylated. {ECO:0000250|UniProtKB:Q9NPY3}.; PTM: Phosphorylated on Tyr-620 and Tyr-636 by SRC; these phosphorylations promote endothelial cell adhesion and migration. {ECO:0000250|UniProtKB:Q9NPY3}.
uniprot
proteins
pubmed
10403644
uniprot
proteins
pubmed
10430665
uniprot
proteins
pubmed
11074255
uniprot
proteins
pubmed
15004139
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20439917
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
38441970
uniprot
proteins
sequence_length
644
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:38441970}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9NPY3}.
uniprot
proteins
transmembrane_region
TRANSMEM 573..593; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins