Bcam
entrez
78958
canonical
uniprot
Q9ESS6
canonical
ensembl
ENSRNOG00000029399
resolver
ensp
ENSRNOP00000047809
resolver
genesymbol
Bcam
resolver
genesymbol_syn
Lu
resolver
uniprot_entry
BCAM_RAT
resolver
amino_acid_sequence
MEPPDARAGLLWLTLLLSGYSGAQAELHVSVPPRVEVMRGEQIALDCTPREHPENYVLEWLLVDASGARHRLASVEPQGSEFLGTIHNSRGRRPPYKIDSLGRLVIAEAQVGDERDYVCVVKAGAAGTSEATSSVRVFATPEATEVAPNKGTLSVMEQFAQEIATCSSNNGNPVPRITWYQNGQRLDVPMELNSKGYMTSRTVREASGLYSLTSTLYLRLHKEDRDASFHCAAHYDLPSGQHGRLDSHTFRLTLHYPTEHVEFWVGSPSTTEGWVREGDAVQLLCQGDGSPSPEYSFFREQGNQEEQLNVNLKGNLTLEGVHRSQSGIYGCRVEDYDADEEVQLVKKLKLHVAYLDPLELSVPEEFSVFLNSSGTVVNCSARGLPAPIVRWTKDSVTVADGPILSLDSVTFDSAGTYTCEASTPTVPLLSRTQSFQLVVQGAPELKPNEIKPKSGTSWTEGDEVMLTCSARGFPEPKLTWSQRGDTTPAEPPFEGRGWMSSSLTLKVTSALSREGVSCEASNIHGKNGHVFHFGSVAPQTAQAGVAVMAVAVSVGLLLLVVAAFYCMRRKGRPGCCQRAEKGAPPAREPELSHSGSERPEHTGLLMGGPSGGGRGGNGGFGDEC
uniprot
proteins
function
FUNCTION: Transmembrane glycoprotein that functions as both a receptor and an adhesion molecule playing a crucial role in cell adhesion, motility, migration and invasion. Extracellular domain enables binding to extracellular matrix proteins, such as laminin, integrin and other ligands while its intracellular domain interacts with cytoskeletal proteins like hemoglobin, facilitating cell signal transduction. Serves as a receptor for laminin alpha-5/LAMA5 to promote cell adhesion. Mechanistically, JAK2 induces BCAM phosphorylation and activates its adhesion to laminin by stimulating a Rap1/AKT signaling pathway in the absence of EPOR. {ECO:0000250|UniProtKB:P50895}.
uniprot
proteins
mass_dalton
67512
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
624
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P50895}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P50895}.
uniprot
proteins
transmembrane_region
TRANSMEM 544..564; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins