Slc4a8
entrez
59033
canonical
uniprot
Q8JZR6
canonical
ensembl
ENSMUSG00000023032
resolver
ensp
ENSMUSP00000023776
resolver
ensp
ENSMUSP00000125090
resolver
genesymbol
Slc4a8
resolver
genesymbol_syn
AW493845
resolver
genesymbol_syn
Kiaa0739
resolver
genesymbol_syn
Ndcbe
resolver
uniprot
Q3TAV7
resolver
uniprot
Q3UR07
resolver
uniprot
Q6A004
resolver
uniprot
Q8BYI7
resolver
uniprot
Q9JKV6
resolver
uniprot_entry
Q3UR07_MOUSE
resolver
uniprot_entry
S4A8_MOUSE
resolver
uniprot_sec
Q3TAV7
resolver
uniprot_sec
Q6A004
resolver
uniprot_sec
Q8BYI7
resolver
uniprot_sec
Q9JKV6
resolver
amino_acid_sequence
MPAGSNEPDGVLSYQRPDEEAVVDQGGTSTILNIHYEKEELEGHRTLYVGVRMPLGRQSHRHHRTHGQKHRRRGGRGKGASQGEEGLEALAHDTPSQRVQFILGTEEDEEHVPHELFTELDEICMKEGEDAEWKETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCLINGSVLLDMRASSIEEISDLILDQQELLRDLSDSVRVKVREALLKKHHHQNERRRNNLIPIVRSFAEVGKKQSDPHSMDRDGQTVSPQSATNLEVKNGVNCEHSPVDLSKVDLHFMKKIPTGAEASNVLVGEVDTLDRPIVAFVRLSPAVLLSGLTEVPIPTRFLFILLGPVGKGQQYHEIGRSMATIMTDEIFHDVAYKAKERDDLLAGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRKMPGVPNGNVCHIEPEPHGGHSGPELERTGRLFGGLVLDVKRKAPWYWSDYRDALSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFAGQPLTILGSTGPVLVFEKILFKFCKDYALSYLSLRALIGLWTAFLCIVLVATDASSLVCYITRFTEEAFASLICIIFIYEAIEKLIHLAETYPIHMHSQLDHLSLYYCRCVLPENPNNHTLQYWKDHNILAAEVNWANLTVSECQEMHGEFMGSACGHHGPYTPDVLFWSCILFFATFIVSSTLKTFKTSRYFPTRVRSMVSDFAVFLTIFTMVVLDFLIGVPSPKLQVPNVFKPTRDDRGWFINPIGPNPWWTVIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFVLMGCSVFMTAVLKFIPMPVLYGVFLYMGVSSLQGIQFFDRLKLFGMPAKHQPDFIYLRHVPLRKVHLFTLVQLTCLVLLWVIKASPAAIVFPMMVLALVFVRKVMDLCFSKRELSWLDDLMPESKKKKLDDAKKKEEEEAEKMLDIGGDKFPLESRKLLSSPGKSSSFRCDPSEINISDEMPKTTVWKALSINSGNTKEKSPFN
uniprot
proteins
function
FUNCTION: Mediates electroneutral sodium- and carbonate-dependent chloride-HCO3(-) exchange with a Na(+):HCO3(-) stoichiometry of 2:1 (PubMed:20389022). Plays a major role in pH regulation in neurons (PubMed:21593314). Mediates sodium reabsorption in the renal cortical collecting ducts (PubMed:20389022). {ECO:0000269|PubMed:20389022, ECO:0000269|PubMed:21593314}.
uniprot
proteins
mass_dalton
122421
uniprot
proteins
protein_family
Anion exchanger (TC 2.A.31) family
uniprot
proteins
pubmed
11260402
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18359573
uniprot
proteins
pubmed
20389022
uniprot
proteins
pubmed
21593314
uniprot
proteins
pubmed
30355950
uniprot
proteins
sequence_length
1089
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18359573, ECO:0000269|PubMed:21593314}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q2Y0W8}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:30355950}; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q6RVG2}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to synaptic junction cell membrane. {ECO:0000269|PubMed:21593314}.
uniprot
proteins
transmembrane_region
TRANSMEM 477..497; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 506..526; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 564..584; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 594..614; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 686..706; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 730..750; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 777..797; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 823..843; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 880..900; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 903..923; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 961..981; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins