Psma4
entrez
29671
canonical
uniprot
P21670
canonical
ensembl
ENSRNOG00000013493
resolver
ensembl
ENSRNOG00055031315
resolver
ensembl
ENSRNOG00060015027
resolver
ensembl
ENSRNOG00065018362
resolver
ensp
ENSRNOP00000018173
resolver
ensp
ENSRNOP00055044881
resolver
ensp
ENSRNOP00060020589
resolver
ensp
ENSRNOP00065024516
resolver
enst
ENSRNOT00000018173
resolver
enst
ENSRNOT00055054272
resolver
enst
ENSRNOT00060025764
resolver
enst
ENSRNOT00065030805
resolver
genesymbol
Psma4
resolver
uniprot_entry
PSA4_RAT
resolver
amino_acid_sequence
MSRRYDSRTTIFSPEGRLYQVEYAMEAIGHAGTCLGILANDGVLLAAERRNIHKLLDEVFFSEKIYKLNEDMACSVAGITSDANVLTNELRLIAQRYLLQYQEPIPCEQLVTALCDIKQAYTQFGGKRPFGVSLLYIGWDKHYGFQLYQSDPSGNYGGWKATCIGNNSAAAVSMLKQDYKEGEMTLKSALALAVKVLNKTMDVSKLSAEKVEIATLTRENGKTVIRVLKQKEVEQLIKKHEEEEAKAEREKKEKEQREKDK
uniprot
proteins
function
FUNCTION: Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). {ECO:0000250|UniProtKB:P25789}.
uniprot
proteins
mass_dalton
29498
uniprot
proteins
protein_family
Peptidase T1A family
uniprot
proteins
pubmed
2249692
uniprot
proteins
pubmed
2358075
uniprot
proteins
sequence_length
261
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P25789}. Nucleus {ECO:0000250|UniProtKB:P25789}. Note=Translocated from the cytoplasm into the nucleus following interaction with AKIRIN2, which bridges the proteasome with the nuclear import receptor IPO9 (By similarity). Colocalizes with TRIM5 in the cytoplasmic bodies (By similarity). {ECO:0000250|UniProtKB:P25789, ECO:0000250|UniProtKB:Q9R1P0}.
uniprot
proteins