Hsd17b4
entrez
79244
canonical
uniprot
P97852
canonical
ensembl
ENSRNOG00000015840
resolver
ensembl
ENSRNOG00060012603
resolver
ensembl
ENSRNOG00065004039
resolver
ensp
ENSRNOP00000070792
resolver
ensp
ENSRNOP00000081103
resolver
ensp
ENSRNOP00060016963
resolver
ensp
ENSRNOP00065004285
resolver
enst
ENSRNOT00000089750
resolver
enst
ENSRNOT00000115693
resolver
enst
ENSRNOT00060021465
resolver
enst
ENSRNOT00065005980
resolver
genesymbol
Hsd17b4
resolver
genesymbol_syn
Edh17b4
resolver
uniprot
A0A0G2JYU4
resolver
uniprot
A0ACM8Q496
resolver
uniprot
P70523
resolver
uniprot
P70540
resolver
uniprot
Q6IN39
resolver
uniprot_entry
A0ACM8Q496_RAT
resolver
uniprot_entry
DHB4_RAT
resolver
uniprot_entry
Q6IN39_RAT
resolver
uniprot_sec
A0A0G2JYU4
resolver
uniprot_sec
P70523
resolver
uniprot_sec
P70540
resolver
amino_acid_sequence
MASPLRFDGRVVLVTGAGGGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSSAADKVVEEIRRRGGKAVANYDSVEAGEKLVKTALDTFGRIDVVVNNAGILRDRSFSRISDEDWDIIQRVHLRGSFQVTRAAWDHMKKQNYGRIIMTASASGIYGNFGQANYSAAKLGLLGLANTLVIEGRKNNIHCNTIAPNAGSRMTETVMPEDLVEALKPEYVAPLVLWLCHESCEENGGLFEVGAGWIGKLRWERTLGAIVRKRNQPMTPEAVRDNWVKICDFSNASKPKSIQESTGGIIEVLHKIDSEGISQNHTGQVASADASGFAGVVGHKLPSFSSSYTELQCIMYALGVGASVKNPKDLKFVYEGSADFSCLPTFGVIVAQKSLMSGGLAEVPGLSINFAKVLHGEQYLELYKPLPRSGELKCEAVIADILDKGSGIVIVMDVYSYSGKELICYNQFSVFVVGSGGFGGKRTSEKLKAAVAVPSRPPDAVLRDTTSLNQAALYRLSGDSNPLHIDPSFASIAGFEKPILHGLCTFGFSARHVLQQFADNDVSRFKAIKVRFAKPVYPGQTLQTEMWKEGNRIHFQTKVQETGDIVISNAYVDLVPTSGVSAQTPSEGGALQSALVFGEIGRRLKDVGREVVKKVNAVFEWHITKNGNVAAKWTIDLKNGSGEVYQGPAKGSADTTITISDEDFMEVVLGKLNPQNAFFSGRLKARGNIMLSQKLQMILKDYAKL
uniprot
proteins
ec_number
1.1.1.n12
uniprot
proteins
ec_number
4.2.1.107
uniprot
proteins
ec_number
4.2.1.119
uniprot
proteins
function
FUNCTION: Bifunctional enzyme acting on the peroxisomal fatty acid beta-oxidation pathway. Catalyzes two of the four reactions in fatty acid degradation: hydration of 2-enoyl-CoA (trans-2-enoyl-CoA) to produce (3R)-3-hydroxyacyl-CoA, and dehydrogenation of (3R)-3-hydroxyacyl-CoA to produce 3-ketoacyl-CoA (3-oxoacyl-CoA), which is further metabolized by SCPx. Can use straight-chain and branched-chain fatty acids, as well as bile acid intermediates as substrates. May play a role in peroxisomal beta-oxidation step in polyunsaturated fatty acids (PUFAs) biosynthesis. Possibly regulates systemic levels of docosahexaenoic acid (DHA, C22:6n-3) through a process involving endoplasmic reticulum desaturation and elongation of alpha-linolenic acid (ALA, C18:3n-3) to form tetracosahexaenoic acid (THA, C24:6n-3), which is then beta-oxidized to DHA in peroxisomes. {ECO:0000250|UniProtKB:P51659}.
uniprot
proteins
mass_dalton
79428
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid beta-oxidation. {ECO:0000250|UniProtKB:P51659}.
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
12517343
uniprot
proteins
pubmed
8856068
uniprot
proteins
pubmed
8913347
uniprot
proteins
pubmed
9003397
uniprot
proteins
pubmed
9003427
uniprot
proteins
sequence_length
735
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:8856068}.
uniprot
proteins