Arl8b
entrez
500282
canonical
uniprot
Q66HA6
canonical
ensembl
ENSRNOG00000055860
resolver
ensembl
ENSRNOG00055019800
resolver
ensembl
ENSRNOG00060014053
resolver
ensembl
ENSRNOG00065012272
resolver
ensp
ENSRNOP00000071470
resolver
ensp
ENSRNOP00055027470
resolver
ensp
ENSRNOP00060019192
resolver
ensp
ENSRNOP00065015322
resolver
enst
ENSRNOT00000080663
resolver
enst
ENSRNOT00055033825
resolver
enst
ENSRNOT00060024074
resolver
enst
ENSRNOT00065019976
resolver
genesymbol
Arl8b
resolver
uniprot_entry
ARL8B_RAT
resolver
amino_acid_sequence
MLALISRLLDWFRSLFWKEEMELTLVGLQYSGKTTFVNVIASGQFSEDMIPTVGFNMRKVTKGNVTIKIWDIGGQPRFRSMWERYCRGVNAIVYMIDAADREKIEASRNELHNLLDKPQLQGIPVLVLGNKRDLPNALDEKQLIEKMNLSAIQDREICCYSISCKEKDNIDITLQWLIQHSKSRRS
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins playing a key role in the regulation of lysosomal positioning which is important for nutrient sensing, natural killer cell-mediated cytotoxicity and antigen presentation. Along with its effectors, orchestrates lysosomal transport and fusion. Localizes specifically to lysosomal membranes and mediates anterograde lysosomal motility by recruiting PLEKHM2, which in turn recruits the motor protein kinesin-1 on lysosomes. Required for lysosomal and cytolytic granule exocytosis. Critical factor involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (By similarity). In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). Also acts as a regulator of endosome to lysosome trafficking pathways of special significance for host defense (By similarity). Recruits RUFY1 onto early endosomes regulating endosomes to trans-Golgi network proteins retrieval (By similarity). Regulates cargo trafficking to lysosomes by binding to PLEKHM1 and recruiting the HOPS subunit VPS41, resulting in functional assembly of the HOPS complex on lysosomal membranes. Plays an important role in cargo delivery to lysosomes for antigen presentation and microbial killing. Directs the intersection of CD1d with lipid antigens in lysosomes, and plays a role in intersecting phagosomes with lysosomes to generate phagolysosomes that kill microbes (By similarity). Involved in the process of MHC II presentation. Regulates the delivery of antigens to lysosomes and the formation of MHC II-peptide complexes through the recruitment of the HOPS complex to lysosomes allowing the fusion of late endosomes to lysosomes (By similarity). May play a role in chromosome segregation (By similarity). {ECO:0000250|UniProtKB:Q9CQW2, ECO:0000250|UniProtKB:Q9NVJ2}.
uniprot
proteins
mass_dalton
21539
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated at Lys-141 by RNF167, leading to its degradation. {ECO:0000250|UniProtKB:Q9NVJ2}.
uniprot
proteins
protein_family
Arf family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
186
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250|UniProtKB:Q9NVJ2}. Lysosome membrane {ECO:0000250|UniProtKB:Q9NVJ2}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9NVJ2}. Cell projection, axon {ECO:0000250|UniProtKB:Q9CQW2}. Synapse {ECO:0000250|UniProtKB:Q9CQW2}. Cytolytic granule membrane {ECO:0000250|UniProtKB:Q9NVJ2}. Early endosome membrane {ECO:0000250|UniProtKB:Q9NVJ2}. Note=GTP-bound form resides on lysosomal membranes, whereas GDP-bound form is likely associated with microtubular structures. Localizes with microtubules at the spindle mid-zone during mitosis (By similarity). In dendritic cells, localizes to MHC II+ compartments (By similarity). {ECO:0000250|UniProtKB:Q9CQW2, ECO:0000250|UniProtKB:Q9NVJ2}.
uniprot
proteins