Irx3
entrez
16373
canonical
uniprot
P81067
canonical
ensembl
ENSMUSG00000031734
resolver
ensp
ENSMUSP00000091002
resolver
ensp
ENSMUSP00000135488
resolver
genesymbol
Irx3
resolver
genesymbol_syn
Irxb1
resolver
uniprot
Q3UPZ3
resolver
uniprot
Q5U3K8
resolver
uniprot_entry
IRX3_MOUSE
resolver
uniprot_sec
Q3UPZ3
resolver
uniprot_sec
Q5U3K8
resolver
amino_acid_sequence
MSFPQLGYQYIRPLYPPERPGAAGGGGGGSSAGGRSGPGAGASELAASGSLSNVLSSVYGAPYAAAAAAAAAAQGYGAFLPYATELPIFPQLGAQYELKDSPGVQHPATAAAFPHPHPAFYPYGQYQFGDPSRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWAPRSRTDEEGNAYGSEREEEDEEEDEEESKRELEMEEEELAGEEEDTGGEGLADDDEDEEIDLENLDSAAAGSELTLAGAAHRNGDFGLGPISDCKTSDSDDSSEGLEDRPLSVLSLAPPPPPVARAPASPPSPPSSLDPCAPAPAPSSALQKPKIWSLAETATSPDNPRRSPPGAGGSPPGAAVAPPTLQLSPAAAAAAAAAHRLVSAPLGKFPAWTNRPFPGPPAGPRPHPLSMLGSAPQHLLGLPGAAGHPAAAAAAYARPAEPESGTDRCSALEVEKKLLKTAFQPVPRRPQNHLDAALVLSALSSS
uniprot
proteins
function
FUNCTION: Transcription factor involved in SHH-dependent neural patterning (PubMed:10830170, PubMed:15201216). Together with NKX2-2 and NKX6-1 acts to restrict the generation of motor neurons to the appropriate region of the neural tube (PubMed:10830170, PubMed:15201216). Belongs to the class I proteins of neuronal progenitor factors, which are repressed by SHH signals (PubMed:10830170, PubMed:15201216). Involved in the transcriptional repression of MNX1 in non-motor neuron cells (PubMed:15201216). Acts as a regulator of energy metabolism (PubMed:24646999). {ECO:0000269|PubMed:10830170, ECO:0000269|PubMed:15201216, ECO:0000269|PubMed:24646999}.
uniprot
proteins
mass_dalton
52693
uniprot
proteins
protein_family
TALE/IRO homeobox family
uniprot
proteins
pubmed
10704856
uniprot
proteins
pubmed
10830170
uniprot
proteins
pubmed
10926765
uniprot
proteins
pubmed
15201216
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17875669
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24646999
uniprot
proteins
pubmed
9427753
uniprot
proteins
pubmed
9486539
uniprot
proteins
sequence_length
507
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins