Pnpla6
entrez
50767
canonical
uniprot
Q3TRM4
canonical
ensembl
ENSMUSG00000004565
resolver
ensp
ENSMUSP00000004681
resolver
ensp
ENSMUSP00000146555
resolver
ensp
ENSMUSP00000146680
resolver
ensp
ENSMUSP00000318585
resolver
ensp
ENSMUSP00000318595
resolver
enst
ENSMUST00000207941
resolver
enst
ENSMUST00000208002
resolver
genesymbol
Pnpla6
resolver
genesymbol_syn
Nte
resolver
uniprot
A0A140LHU9
resolver
uniprot
A0A140LI54
resolver
uniprot
Q7TQD6
resolver
uniprot
Q9R114
resolver
uniprot_entry
A0A140LHU9_MOUSE
resolver
uniprot_entry
A0A140LI54_MOUSE
resolver
uniprot_entry
PLPL6_MOUSE
resolver
uniprot_sec
Q7TQD6
resolver
uniprot_sec
Q9R114
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by a series a OPs such as mipafox (MPX), phenyl saligenin phosphate (PSP), phenyl dipentyl phosphinate (PDPP), diisopropyl fluorophosphate and paraoxon. {ECO:0000269|PubMed:16963094}.
uniprot
proteins
amino_acid_sequence
MGTPSHELNTTSSGAEVIQKTLEEGLGRRICVAQPVPFVPQVLGVMIGAGVAVLVTAVLILLVVRRLRVQKTPAPEGPRYRFRKRDKVLFYGRKIMRKVSQSTSSLVDTSVSTTSRPRMKKKLKMLNIAKKILRIQKETPTLQRKEPPPSVLEADLTEGDLANSHLPSEVLYMLKNVRVLGHFEKPLFLELCRHMVFQRLGQGDYVFRPGQPDASIYVVQDGLLELCLPGPDGKECVVKEVVPGDSVNSLLSILDVITGHQHPQRTVSARAARDSTVLRLPVEAFSAVFTKYPESLVRVVQIIMVRLQRVTFLALHNYLGLTNELFSHEIQPLRLFPSPGLPTRTSPVRGSKRVVSTSGTEDTSKETSGRPLDSIGAPLPGPAGDPVKPTSLEAPPAPLLSRCISMPVDISGLQGGPRSDFDMAYERGRISVSLQEEASGGPQTASPRELREQPAGACEYSYCEDESATGGCPFGPYQGRQTSSIFEAAKRELAKLMRIEDPSLLNSRVLLHHAKAGTIIARQGDQDVSLHFVLWGCLHVYQRMIDKAEEVCLFVAQPGELVGQLAVLTGEPLIFTLRAQRDCTFLRISKSHFYEIMRAQPSVVLSAAHTVAARMSPFVRQMDFAIDWTAVEAGRALYRQGDRSDCTYIVLNGRLRSVIQRGSGKKELVGEYGRGDLIGVVEALTRQPRATTVHAVRDTELAKLPEGTLGHIKRRYPQVVTRLIHLLSQKILGNLQQLQGPFPGSGLSVPQHSELTNPASNLSTVAILPVCAEVPMMAFTLELQHALQAIGPTLLLNSDVIRALLGASALDSIQEFRLSGWLAQQEDAHRIVLYQTDTSLTPWTVRCLRQADCILIVGLGDQEPTVGQLEQMLENTAVRALKQLVLLHREEGPGPTRTVEWLNMRSWCSGHLHLRCPRRLFSRRSPAKLHELYEKVFSRRADRHSDFSRLARVLTGNTIALVLGGGGARGCSHIGVLKALEEAGVPVDLVGGTSIGSFIGALYAEERSASRTKQRAREWAKSMTSVLEPVLDLTYPVTSMFTGSAFNRSIHRVFQDKQIEDLWLPYFNVTTDITASAMRVHKDGSLWRYVRASMTLSGYLPPLCDPKDGHLLMDGGYINNLPADIARSMGAKTVIAIDVGSQDETDLSTYGDSLSGWWLLWKRLNPWADKVKVPDMAEIQSRLAYVSCVRQLEVVKSSSYCEYLRPSIDCFKTMDFGKFDQIYDVGYQYGKAVFGGWTRGEVIEKMLTDRRSTDLNESRRADILAFPSSGFTDLAEIVSRIEPPTSYVSDGCADGEESDCLTEYEEDAGPDCSRDEGGSPEGASPSTASEVEEEKSTLRQRRFLPQETPSSVADA
uniprot
proteins
ec_number
3.1.1.5
uniprot
proteins
function
FUNCTION: Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho) (Probable) (PubMed:18086666). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Catalyzes the hydrolysis of several naturally occurring membrane-associated lipids. Hydrolyzes lysophospholipids and monoacylglycerols, preferring the 1-acyl to the 2-acyl isomer. Does not catalyze hydrolysis of di- or triacylglycerols or fatty acid amides (By similarity). {ECO:0000250|UniProtKB:Q8IY17, ECO:0000269|PubMed:18086666, ECO:0000305|PubMed:16963094}.
uniprot
proteins
mass_dalton
149537
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250}.
uniprot
proteins
protein_family
NTE family
uniprot
proteins
pubmed
10640712
uniprot
proteins
pubmed
12640454
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16963094
uniprot
proteins
pubmed
18086666
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1355
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:16963094}; Single-pass type III membrane protein {ECO:0000305|PubMed:16963094}.
uniprot
proteins
transmembrane_region
TRANSMEM 44..64; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins