NCKAP5L
entrez
57701
canonical
uniprot
Q9HCH0
canonical
ensembl
ENSG00000167566
resolver
ensp
ENSP00000337998
resolver
ensp
ENSP00000576757
resolver
ensp
ENSP00000584492
resolver
ensp
ENSP00000700482
resolver
genesymbol
NCKAP5L
resolver
genesymbol_syn
CEP169
resolver
genesymbol_syn
KIAA1602
resolver
hgnc
HGNC:29321
resolver
uniprot
Q2TB26
resolver
uniprot
Q71RH1
resolver
uniprot
Q8N4W1
resolver
uniprot
Q96HX2
resolver
uniprot_entry
NCK5L_HUMAN
resolver
uniprot_sec
Q2TB26
resolver
uniprot_sec
Q71RH1
resolver
uniprot_sec
Q8N4W1
resolver
uniprot_sec
Q96HX2
resolver
amino_acid_sequence
MSEAMDQPAGGPGNPRPGEGDDGSMEPGTCQELLHRLRELEAENSALAQANENQRETYERCLDEVANHVVQALLNQKDLREECIKLKKRVFDLERQNQMLSALFQQKLQLTTGSLPQIPLTPLQPPSEPPASPSLSSTEGPAAPLPLGHCAGQREVCWEQQLRPGGPGPPAAPPPALDALSPFLRKKAQILEVLRALEETDPLLLCSPATPWRPPGQGPGSPEPINGELCGPPQPEPSPWAPCLLLGPGNLGGLLHWERLLGGLGGEEDTGRPWGPSRGPPQAQGTSSGPNCAPGSSSSSSSDEAGDPNEAPSPDTLLGALARRQLNLGQLLEDTESYLQAFLAGAAGPLNGDHPGPGQSSSPDQAPPQLSKSKGLPKSAWGGGTPEAHRPGFGATSEGQGPLPFLSMFMGAGDAPLGSRPGHPHSSSQVKSKLQIGPPSPGEAQGPLLPSPARGLKFLKLPPTSEKSPSPGGPQLSPQLPRNSRIPCRNSGSDGSPSPLLARRGLGGGELSPEGAQGLPTSPSPCYTTPDSTQLRPPQSALSTTLSPGPVVSPCYENILDLSRSTFRGPSPEPPPSPLQVPTYPQLTLEVPQAPEVLRSPGVPPSPCLPESYPYGSPQEKSLDKAGSESPHPGRRTPGNSSKKPSQGSGRRPGDPGSTPLRDRLAALGKLKTGPEGALGSEKNGVPARPGTEKTRGPGKSGESAGDMVPSIHRPLEQLEAKGGIRGAVALGTNSLKQQEPGLMGDPGARVYSSHSMGARVDLEPVSPRSCLTKVELAKSRLAGALCPQVPRTPAKVPTSAPSLGKPNKSPHSSPTKLPSKSPTKVVPRPGAPLVTKESPKPDKGKGPPWADCGSTTAQSTPLVPGPTDPSQGPEGLAPHSAIEEKVMKGIEENVLRLQGQERAPGAEVKHRNTSSIASWFGLKKSKLPALNRRTEATKNKEGAGGGSPLRREVKMEARKLEAESLNISKLMAKAEDLRRALEEEKAYLSSRARPRPGGPAPGPNTGLGQVQGQLAGMYQGADTFMQQLLNRVDGKELPSKSWREPKPEYGDFQPVSSDPKSPWPACGPRNGLVGPLQGCGKPPGKPSSEPGRREEMPSEDSLAEPVPTSHFTACGSLTRTLDSGIGTFPPPDHGSSGTPSKNLPKTKPPRLDPPPGVPPARPPPLTKVPRRAHTLEREVPGIEELLVSGRHPSMPAFPALLPAAPGHRGHETCPDDPCEDPGPTPPVQLAKNWTFPNTRAAGSSSDPLMCPPRQLEGLPRTPMALPVDRKRSQEPSRPSPTPQGPPFGGSRTPSTSDMAEEGRVASGGPPGLETSESLSDSLYDSLSSCGSQG
uniprot
proteins
function
FUNCTION: Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylation of microtubules (PubMed:26482847, PubMed:26485573). Both tubulin-binding and homodimer formation are required for NCKAP5L-mediated microtubule bundle formation (PubMed:26485573). {ECO:0000269|PubMed:26482847, ECO:0000269|PubMed:26485573}.
uniprot
proteins
mass_dalton
139462
uniprot
proteins
mutagenesis
MUTAGEN 486..487; /note="IP->AA: No decrease in localization to microtubule plus ends. Loss of interaction with MAPRE1 and localization to microtubule plus ends; when associated with 818-A-A-819 and 928-A-A-929."; /evidence="ECO:0000269|PubMed:26482847, ECO:0000269|PubMed:26485573"; MUTAGEN 818..819; /note="LP->AA: No decrease in localization to microtubule plus ends. Loss of interaction with MAPRE1 and localization to microtubule plus ends; when associated with 486-A-A-487 and 928-A-A-929."; /evidence="ECO:0000269|PubMed:26482847, ECO:0000269|PubMed:26485573"; MUTAGEN 928..929; /note="LP->AA: Loss of interaction with MAPRE1 and significantly reduced localization to microtubule plus ends. Loss of interaction with MAPRE1 and localization to microtubule plus ends; when associated with 486-A-A-487 and 818-A-A-819."; /evidence="ECO:0000269|PubMed:26482847, ECO:0000269|PubMed:26485573
uniprot
proteins
post_translational_modification
PTM: CDK1/Cyclin B-dependent phosphorylation mediates its dissociation from centrosomes during mitosis. {ECO:0000269|PubMed:26549230}.
uniprot
proteins
pubmed
10997877
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26482847
uniprot
proteins
pubmed
26485573
uniprot
proteins
pubmed
26549230
uniprot
proteins
sequence_length
1334
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:26482847, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:26549230}. Note=Localizes to microtubule plus ends (PubMed:26482847, PubMed:26485573). Associates with centrosomes during interphase, but dissociates from these structures from the onset of mitosis (PubMed:26549230). {ECO:0000269|PubMed:26482847, ECO:0000269|PubMed:26485573, ECO:0000269|PubMed:26549230}.
uniprot
proteins