Sidt2
entrez
315617
canonical
uniprot
D3ZEH5
canonical
ensembl
ENSRNOG00000017871
resolver
ensp
ENSRNOP00000024239
resolver
ensp
ENSRNOP00000035750
resolver
ensp
ENSRNOP00000092236
resolver
enst
ENSRNOT00000024240
resolver
enst
ENSRNOT00000035310
resolver
enst
ENSRNOT00000111154
resolver
genesymbol
Sidt2
resolver
uniprot
A0A0A0MP80
resolver
uniprot
A0A8I6ADA5
resolver
uniprot
A0A8L2QIN5
resolver
uniprot
D3ZSU1
resolver
uniprot_entry
A0A0A0MP80_RAT
resolver
uniprot_entry
A0A8I6ADA5_RAT
resolver
uniprot_entry
A0A8L2QIN5_RAT
resolver
uniprot_entry
SIDT2_RAT
resolver
uniprot_sec
D3ZSU1
resolver
amino_acid_sequence
MIAWRLPLCVLLVAAVESHLGALGPKNVSQKDAEFERTYADDVNSELVNIYTFNHTVTRNRTEGVRVSVNVLNKQKGAPLLFVVRQKEAVVSFQVPLILRGLYQRKYLYQKVERTLCQPPTKNESEIQFFYVDVSTLSPVNTTYQLRVNRVDNFVLRTGELFTFNTTAAQPQYFKYEFPDGVDSVIVKVTSKKAFPCSVISIQDVLCPVYDLDNNVAFIGMYQTMTKKAAITVQRKDFPSNSFYVVVVVKTEDQACGGSLPFYPFVEDEPVDQGHRQKTLSVLVSQAVTSEAYVGGMLFCLGIFLSFYLLTVLLACWENWRQRKKTLLVAIDRACPESGHPRVLADSFPGSAPYEGYNYGSFENGSGSTDGLVESTGSGDLSYSYQDRSFDPVGARPRLDSMSSVEEDDYDTLTDIDSDKNVIRTKQYLCVADLARKDKRVLRKKYQIYFWNIATIAVFYALPVVQLVITYQTVVNVTGNQDICYYNFLCAHPLGNLSAFNNILSNLGYILLGLLFLLIILQREINHNRALLRNDLYALECGIPKHFGLFYAMGTALMMEGLLSACYHVCPNYTNFQFDTSFMYMIAGLCMLKLYQKRHPDINASAYSAYACLAIVIFFSVLGVVFGKGNTAFWIVFSVIHIISTLLLSTQLYYMGRWKLDSGIFRRILHVLYTDCIRQCSGPLYTDRMVLLVMGNIINWSLAAYGLIMRPNDFASYLLAIGICNLLLYFAFYIIMKLRSGERIKLIPLLCIVCTSVVWGFALFFFFQGLSTWQKTPAESREHNRDCILLDFFDDHDIWHFLSSIAMFGSFLVLLTLDDDLDTVQRDKIYVF
uniprot
proteins
function
FUNCTION: Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported into lysosomes in an ATP-dependent manner, and degraded. Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis (By similarity). In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA. Binds long double-stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than 100 bp (By similarity). {ECO:0000250|UniProtKB:Q8CIF6, ECO:0000250|UniProtKB:Q8NBJ9}.
uniprot
proteins
mass_dalton
94527
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:20965152}.
uniprot
proteins
protein_family
SID1 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
20965152
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
832
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q8NBJ9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8NBJ9}. Cell membrane {ECO:0000250|UniProtKB:Q8NBJ9}. Note=Mainly localizes to lysosomes and only partly to the plasma membrane (By similarity). Lysosomal localization is required for SIDT2-mediated intracellular degradation of endogenous RNA (By similarity). {ECO:0000250|UniProtKB:Q8CIF6, ECO:0000250|UniProtKB:Q8NBJ9}.
uniprot
proteins
transmembrane_region
TRANSMEM 294..314; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 448..468; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 500..520; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 547..567; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 606..626; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 632..652; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 689..709; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 716..736; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 747..767; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 797..817; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins