Dntt
entrez
21673
canonical
uniprot
P09838
canonical
ensembl
ENSMUSG00000025014
resolver
ensp
ENSMUSP00000062078
resolver
ensp
ENSMUSP00000107819
resolver
genesymbol
Dntt
resolver
genesymbol_syn
Tdt
resolver
uniprot
Q3UZ80
resolver
uniprot
Q99PD0
resolver
uniprot
Q99PD1
resolver
uniprot_entry
Q3UZ80_MOUSE
resolver
uniprot_entry
TDT_MOUSE
resolver
uniprot_sec
Q99PD0
resolver
uniprot_sec
Q99PD1
resolver
amino_acid_sequence
MDPLQAVHLGPRKKRPRQLGTPVASTPYDIRFRDLVLFILEKKMGTTRRAFLMELARRKGFRVENELSDSVTHIVAENNSGSDVLEWLQLQNIKASSELELLDISWLIECMGAGKPVEMMGRHQLVVNRNSSPSPVPGSQNVPAPAVKKISQYACQRRTTLNNYNQLFTDALDILAENDELRENEGSCLAFMRASSVLKSLPFPITSMKDTEGIPCLGDKVKSIIEGIIEDGESSEAKAVLNDERYKSFKLFTSVFGVGLKTAEKWFRMGFRTLSKIQSDKSLRFTQMQKAGFLYYEDLVSCVNRPEAEAVSMLVKEAVVTFLPDALVTMTGGFRRGKMTGHDVDFLITSPEATEDEEQQLLHKVTDFWKQQGLLLYCDILESTFEKFKQPSRKVDALDHFQKCFLILKLDHGRVHSEKSGQQEGKGWKAIRVDLVMCPYDRRAFALLGWTGSRQFERDLRRYATHERKMMLDNHALYDRTKRVFLEAESEEEIFAHLGLDYIEPWERNA
uniprot
proteins
ec_number
2.7.7.31
uniprot
proteins
ec_number
3.1.11.-
uniprot
proteins
function
FUNCTION: [Isoform TDT-S]: Transferase that catalyzes the nontemplated addition of nucleoside triphosphate to coding ends during V(D)J recombination (N addition). Involved in the generation of diversity in the antigen-binding region of immunoglobulin heavy and light chains and T-cell receptors during B- and T-cell development. Does not act on double-stranded DNA with blunt ends. {ECO:0000269|PubMed:11136823, ECO:0000269|PubMed:11938351, ECO:0000269|PubMed:23856622, ECO:0000269|PubMed:7556063, ECO:0000269|PubMed:8464703}.; FUNCTION: [Isoform TDT-L]: 3'-to-5' DNA exonuclease. Involved in the generation of diversity in the antigen-binding region of immunoglobulin heavy and light chains and T-cell receptors during B- and T-cell development. Acts on single-stranded and double-stranded DNA with 3' or 5' extensions, but not on double-stranded DNA with blunt ends. Attenuates not only isoform TDT-S-catalyzed N addition, but also P (palindromic) addition in coding joins (PubMed:11938351). Lacks terminal transferase activity (PubMed:11136823, PubMed:7556063). {ECO:0000269|PubMed:11136823, ECO:0000269|PubMed:11938351, ECO:0000269|PubMed:7556063}.
uniprot
proteins
mass_dalton
58266
uniprot
proteins
mutagenesis
MUTAGEN 29; /note="D->A: Almost complete loss of exonuclease activity in TDT-L; when associated with A-170 and A-473. Decreased transferase activity in TDT-S; when associated with A-170 and A-473."; /evidence="ECO:0000269|PubMed:11938351"; MUTAGEN 170; /note="D->A: Almost complete loss of exonuclease activity in TDT-L; when associated with A-29 and A-473. Decreased transferase activity in TDT-S; when associated with A-29 and A-473."; /evidence="ECO:0000269|PubMed:11938351"; MUTAGEN 342; /note="H->A: Nearly abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:23856622"; MUTAGEN 398; /note="L->A: Nearly abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:23856622"; MUTAGEN 399; /note="D->A: Nearly abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:23856622"; MUTAGEN 400; /note="H->A: Reduces enzyme activity."; /evidence="ECO:0000269|PubMed:23856622"; MUTAGEN 403; /note="K->A: Nearly abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:23856622"; MUTAGEN 473; /note="D->A: Almost complete loss of exonuclease activity in TDT-L; when associated with A-29 and A-170. Decreased transferase activity in TDT-S; when associated with A-29 and A-170."; /evidence="ECO:0000269|PubMed:11938351"; MUTAGEN 473; /note="D->A: Nearly abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:23856622"; MUTAGEN 475; /note="H->A: Nearly abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:23856622
uniprot
proteins
protein_family
DNA polymerase type-X family
uniprot
proteins
pubmed
10878023
uniprot
proteins
pubmed
11032847
uniprot
proteins
pubmed
11136823
uniprot
proteins
pubmed
11823435
uniprot
proteins
pubmed
11938351
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23856622
uniprot
proteins
pubmed
23968551
uniprot
proteins
pubmed
3755527
uniprot
proteins
pubmed
7556063
uniprot
proteins
pubmed
8464703
uniprot
proteins
sequence_length
510
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform TDT-S]: Nucleus {ECO:0000269|PubMed:7556063}.; SUBCELLULAR LOCATION: [Isoform TDT-L]: Nucleus {ECO:0000269|PubMed:11136823}. Cytoplasm {ECO:0000269|PubMed:7556063}. Note=The subcellular location is controversial. Detected in the nucleus (PubMed:11136823). Found mainly in the cytoplasm (PubMed:7556063). {ECO:0000269|PubMed:11136823, ECO:0000269|PubMed:7556063}.
uniprot
proteins