CPZ
entrez
8532
canonical
uniprot
Q66K79
canonical
ensembl
ENSG00000109625
resolver
ensp
ENSP00000315074
resolver
ensp
ENSP00000354255
resolver
ensp
ENSP00000371920
resolver
genesymbol
CPZ
resolver
hgnc
HGNC:2333
resolver
uniprot
A0A384MDV6
resolver
uniprot
O00520
resolver
uniprot
Q96MX2
resolver
uniprot_entry
A0A384MDV6_HUMAN
resolver
uniprot_entry
CBPZ_HUMAN
resolver
uniprot_sec
O00520
resolver
uniprot_sec
Q96MX2
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by 2-mercaptomethyl-3-guanidinoethylthiopropanoic acid (MGTA) and guanidinoethylmercaptosuccinic acid (GEMSA). Inhibited by chelating agents such as EDTA and EGTA. {ECO:0000269|PubMed:9099699}.
uniprot
proteins
amino_acid_sequence
MPPPLPLLLLTVLVVAAARPGCEFERNPAGECHRPPAADSATCVDLQLRTCSDAAYNHTTFPNLLQHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEGGWVRRPCRHICEGLREVCQPAFDAIDMAWPYFLDCHRYFTREDEGCYDPLEKLRGGLEADEALPSGLPPTFIRFSHHSYAQMVRVLRRTASRCAHVARTYSIGRSFDGRELLVIEFSSRPGQHELMEPEVKLIGNIHGNEVAGREMLIYLAQYLCSEYLLGNPRIQRLLNTTRIHLLPSMNPDGYEVAAAEGAGYNGWTSGRQNAQNLDLNRNFPDLTSEYYRLAETRGARSDHIPIPQHYWWGKVAPETKAIMKWMQTIPFVLSASLHGGDLVVSYPFDFSKHPQEEKMFSPTPDEKMFKLLSRAYADVHPMMMDRSENRCGGNFLKRGSIINGADWYSFTGGMSDFNYLHTNCFEITVELGCVKFPPEEALYILWQHNKESLLNFVETVHRGIKGVVTDKFGKPVKNARISVKGIRHDITTAPDGDYWRLLPPGIHIVIAQAPGYAKVIKKVIIPARMKRAGRVDFILQPLGMGPKNFIHGLRRTGPHDPLGGASSLGEATEPDPLRARRQPSADGSKPWWWSYFTSLSTHRPRWLLKY
uniprot
proteins
ec_number
3.4.17.-
uniprot
proteins
function
FUNCTION: Specifically cleaves substrates and peptides with C-terminal basic amino acids, especially those containing C-terminal Arg residues. Probably modulates the Wnt signaling pathway, by cleaving some undefined protein. May play a role in cleavage during prohormone processing. {ECO:0000269|PubMed:11766880, ECO:0000269|PubMed:12417617, ECO:0000269|PubMed:33217972, ECO:0000269|PubMed:9099699}.
uniprot
proteins
mass_dalton
73655
uniprot
proteins
protein_family
Peptidase M14 family
uniprot
proteins
pubmed
10080937
uniprot
proteins
pubmed
10671522
uniprot
proteins
pubmed
11766880
uniprot
proteins
pubmed
12417617
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
33217972
uniprot
proteins
pubmed
9099699
uniprot
proteins
sequence_length
652
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000269|PubMed:10671522, ECO:0000269|PubMed:33217972}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:10671522}. Note=Part of the secreted CPZ is bound to the extracellular matrix. {ECO:0000269|PubMed:10671522}.
uniprot
proteins