Pgk1
entrez
18655
canonical
uniprot
P09411
canonical
ensembl
ENSMUSG00000062070
resolver
ensp
ENSMUSP00000080302
resolver
enst
ENSMUST00000081593
resolver
genesymbol
Pgk1
resolver
genesymbol_syn
Pgk-1
resolver
uniprot
Q3TPE6
resolver
uniprot
Q3UKV8
resolver
uniprot
Q5XJE7
resolver
uniprot_entry
PGK1_MOUSE
resolver
uniprot_sec
Q3TPE6
resolver
uniprot_sec
Q3UKV8
resolver
uniprot_sec
Q5XJE7
resolver
amino_acid_sequence
MSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAAELKSLLGKDVLFLKDCVGPEVENACANPAAGTVILLENLRFHVEEEGKGKDASGNKVKAEPAKIDAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTSLYDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGTESSKKYAEAVGRAKQIVWNGPVGVFEWEAFARGTKSLMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEGKVLPGVDALSNV
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
ec_number
2.7.2.3
uniprot
proteins
function
FUNCTION: Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. Both L- and D- forms of purine and pyrimidine nucleotides can be used as substrates, but the activity is much lower on pyrimidines. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). Acts as a protein kinase when localized to the mitochondrion where it phosphorylates pyruvate dehydrogenase kinase PDK1 to inhibit pyruvate dehydrogenase complex activity and suppress the formation of acetyl-coenzyme A from pyruvate, and consequently inhibit oxidative phosphorylation and promote glycolysis. May play a role in sperm motility. {ECO:0000250|UniProtKB:P00558}.
uniprot
proteins
mass_dalton
44550
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. {ECO:0000250|UniProtKB:P00558}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-203 by MAPK1/ERK2 under hypoxic conditions, which promotes its mitochondrial targeting. {ECO:0000250|UniProtKB:P00558}.
uniprot
proteins
protein_family
Phosphoglycerate kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
1975492
uniprot
proteins
pubmed
19759366
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2166582
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
3440520
uniprot
proteins
pubmed
3525226
uniprot
proteins
pubmed
3542714
uniprot
proteins
sequence_length
417
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P00558}. Mitochondrion matrix {ECO:0000250|UniProtKB:P00558}. Note=Hypoxic conditions promote mitochondrial targeting. Targeted to the mitochondrion following phosphorylation by MAPK1/ERK2, cis-trans isomerization by PIN1, and binding to mitochondrial circRNA mcPGK1. {ECO:0000250|UniProtKB:P00558}.
uniprot
proteins