ARGLU1
entrez
55082
canonical
uniprot
Q9NWB6
canonical
ensembl
ENSG00000134884
resolver
ensp
ENSP00000383059
resolver
genesymbol
ARGLU1
resolver
hgnc
HGNC:25482
resolver
uniprot
B4E0Y3
resolver
uniprot
Q5T257
resolver
uniprot
Q6IQ34
resolver
uniprot_entry
ARGL1_HUMAN
resolver
uniprot_sec
B4E0Y3
resolver
uniprot_sec
Q5T257
resolver
uniprot_sec
Q6IQ34
resolver
amino_acid_sequence
MGRSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNTAVSRRERDRERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKIILGKGKSRPKLSFSLKTQD
uniprot
proteins
function
FUNCTION: Dual function regulator of gene expression; regulator of transcription and modulator of alternative splicing (PubMed:30698747). General coactivator of nuclear receptor-induced gene expression, including genes activated by the glucocorticoid receptor NR3C1 (PubMed:30698747). Binds to a subset of pre-mRNAs and to components of the spliceosome machinery to directly modulate basal alternative splicing; involved in simple and complex cassette exon splicing events (PubMed:30698747). Binds its own pre-mRNA and regulates its alternative splicing and degradation; one of the alternatively spliced products is a stable intronic sequence RNA (sisRNA) that binds the protein to regulate its ability to affect splicing (PubMed:27899669, PubMed:36533631). Binding of the sisRNA stimulates phase separation and localization to nuclear speckles, which may contribute to activation of nuclear receptor-induced gene expression (PubMed:36533631). May also indirectly modulate alternative splicing (PubMed:30698747). Regulates transcription of genes involved in heart development, neuronal cell function, protein localization and chromatin localization (By similarity). Regulates splicing of genes involved in neurogenesis and chromatin organization (By similarity). Essential for central nervous system development (By similarity). Required for the estrogen-dependent expression of ESR1 target genes (PubMed:21454576). Can act in cooperation with MED1 (PubMed:21454576). {ECO:0000250|UniProtKB:Q3UL36, ECO:0000269|PubMed:21454576, ECO:0000269|PubMed:27899669, ECO:0000269|PubMed:30698747, ECO:0000269|PubMed:36533631}.
uniprot
proteins
mass_dalton
33216
uniprot
proteins
mutagenesis
MUTAGEN 172..176; /note="LLEEL->AAEEA: Does not disrupt nuclear receptor coactivator activity; on its own or when associated with 201-AERAA-205."; /evidence="ECO:0000269|PubMed:30698747"; MUTAGEN 201..205; /note="LERIL->AERAA: Does not disrupt nuclear receptor coactivator activity; on its own or when associated with 172-AAEEA-176."; /evidence="ECO:0000269|PubMed:30698747
uniprot
proteins
protein_family
ARGLU1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21454576
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27899669
uniprot
proteins
pubmed
30698747
uniprot
proteins
pubmed
36533631
uniprot
proteins
sequence_length
273
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21454576, ECO:0000269|PubMed:30698747}. Nucleus speckle {ECO:0000269|PubMed:30698747, ECO:0000269|PubMed:36533631}. Chromosome {ECO:0000269|PubMed:21454576}. Note=Recruited, in an estrogen-dependent manner, to ESR1 target gene promoters (PubMed:21454576). Colocalizes with MED1 in nuclear speckles (PubMed:21454576, PubMed:36533631). Binding of sisRNA promotes phase separation and localization to nuclear speckles (PubMed:36533631). Associated with glucocorticoid response elements of target genes, even in the absence of glucocorticoid receptor ligands (By similarity). {ECO:0000250|UniProtKB:Q3UL36, ECO:0000269|PubMed:21454576, ECO:0000269|PubMed:36533631}.
uniprot
proteins