Tfap2a
entrez
21418
canonical
uniprot
P34056
canonical
ensembl
ENSMUSG00000021359
resolver
ensp
ENSMUSP00000021787
resolver
ensp
ENSMUSP00000105822
resolver
ensp
ENSMUSP00000153149
resolver
ensp
ENSMUSP00000153271
resolver
ensp
ENSMUSP00000153522
resolver
ensp
ENSMUSP00000153667
resolver
enst
ENSMUST00000021787
resolver
enst
ENSMUST00000110193
resolver
enst
ENSMUST00000223869
resolver
enst
ENSMUST00000224665
resolver
enst
ENSMUST00000224999
resolver
enst
ENSMUST00000225180
resolver
genesymbol
Tfap2a
resolver
genesymbol_syn
Ap2tf
resolver
genesymbol_syn
Tcfap2a
resolver
uniprot
A0A0R4J1E6
resolver
uniprot
A0A286YCU0
resolver
uniprot
A0A286YD43
resolver
uniprot
A0A286YDR3
resolver
uniprot
F6SDL9
resolver
uniprot
Q3UL09
resolver
uniprot
Q60740
resolver
uniprot
Q60741
resolver
uniprot
Q60742
resolver
uniprot
Q60743
resolver
uniprot
Q62067
resolver
uniprot
Q62068
resolver
uniprot
Q62069
resolver
uniprot
Q8BPN4
resolver
uniprot
Q91VX0
resolver
uniprot
Q9CRY4
resolver
uniprot_entry
A0A0R4J1E6_MOUSE
resolver
uniprot_entry
A0A286YCU0_MOUSE
resolver
uniprot_entry
A0A286YD43_MOUSE
resolver
uniprot_entry
A0A286YDR3_MOUSE
resolver
uniprot_entry
AP2A_MOUSE
resolver
uniprot_entry
F6SDL9_MOUSE
resolver
uniprot_entry
Q3UL09_MOUSE
resolver
uniprot_entry
Q8BPN4_MOUSE
resolver
uniprot_sec
Q60740
resolver
uniprot_sec
Q60741
resolver
uniprot_sec
Q60742
resolver
uniprot_sec
Q60743
resolver
uniprot_sec
Q62067
resolver
uniprot_sec
Q62068
resolver
uniprot_sec
Q62069
resolver
uniprot_sec
Q91VX0
resolver
uniprot_sec
Q9CRY4
resolver
amino_acid_sequence
MLWKLTDNIKYEDCEDRHDGTSNGTARLPQLGTVGQSPYTSAPPLSHTPNADFQPPYFPPPYQPIYPQSQDPYSHVNDPYSLNPLHAQPQPQHPGWPGQRQSQESGLLHTHRGLPHQLSGLDPRRDYRRHEDLLHGPHALGSGLGDLPIHSLPHAIEDVPHVEDPGINIPDQTVIKKGPVSLSKSNSNAVSAIPINKDNLFGGVVNPNEVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAANVTLLTSLVEGEAVHLARDFGYVCETEFPAKAVAEFLNRQHSDPNEQVARKNMLLATKQICKEFTDLLAQDRSPLGNSRPNPILEPGIQSCLTHFNLISHGFGSPAVCAAVTALQNYLTEALKAMDKMYLSNNPNSHTDNSAKSSDKEEKHRK
uniprot
proteins
function
FUNCTION: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18 and C/EBP alpha. Is involved in the negative regulation of Wnt canonical signaling, and is a transcriptional repressor of MYC (By similarity). AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. {ECO:0000250|UniProtKB:P05549, ECO:0000269|PubMed:15475956}.
uniprot
proteins
mass_dalton
47971
uniprot
proteins
post_translational_modification
PTM: Sumoylated on Lys-10; which inhibits transcriptional activity. {ECO:0000250}.
uniprot
proteins
protein_family
AP-2 family
uniprot
proteins
pubmed
12504852
uniprot
proteins
pubmed
15475956
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1989904
uniprot
proteins
pubmed
7750631
uniprot
proteins
pubmed
8233835
uniprot
proteins
sequence_length
437
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P05549}.
uniprot
proteins