SAP18
entrez
10284
canonical
uniprot
O00422
canonical
ensembl
ENSG00000150459
resolver
ensp
ENSP00000371973
resolver
genesymbol
SAP18
resolver
hgnc
HGNC:10530
resolver
uniprot
B2R494
resolver
uniprot
Q2TTR4
resolver
uniprot
Q6IAW9
resolver
uniprot
Q8N606
resolver
uniprot
Q9UF14
resolver
uniprot
X6RAL5
resolver
uniprot_entry
SAP18_HUMAN
resolver
uniprot_sec
B2R494
resolver
uniprot_sec
Q2TTR4
resolver
uniprot_sec
Q6IAW9
resolver
uniprot_sec
Q8N606
resolver
uniprot_sec
Q9UF14
resolver
uniprot_sec
X6RAL5
resolver
amino_acid_sequence
MAVESRVTQEEIKKEPEKPIDREKTCPLLLRVFTTNNGRHHRMDEFSRGNVPSSELQIYTWMDATLKELTSLVKEVYPEARKKGTHFNFAIVFTDVKRPGYRVKEIGSTMSGRKGTDDSMTLQSQKFQIGDYLDIAITPPNRAPPPSGRMRPY
uniprot
proteins
function
FUNCTION: Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. {ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:20966198, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:9150135}.
uniprot
proteins
mass_dalton
17561
uniprot
proteins
mutagenesis
MUTAGEN 118; /note="D->A: Abolishes splicing regulation activity and interaction with RNPS1 and ACIN1; when associated with A-121."; /evidence="ECO:0000269|PubMed:20966198"; MUTAGEN 121; /note="T->A: Abolishes splicing regulation activity and interaction with RNPS1 and ACIN1; when associated with A-118."; /evidence="ECO:0000269|PubMed:20966198"; MUTAGEN 126; /note="K->A: No effect on splicing regulation activity."; /evidence="ECO:0000269|PubMed:20966198
uniprot
proteins
protein_family
SAP18 family
uniprot
proteins
pubmed
12665594
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16314458
uniprot
proteins
pubmed
17002296
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20966198
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22203037
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
9150135
uniprot
proteins
sequence_length
153
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16314458}. Cytoplasm {ECO:0000269|PubMed:16314458}. Nucleus speckle {ECO:0000269|PubMed:20966198}. Note=Shuttles between the nucleus and the cytoplasm (PubMed:16314458). Colocalizes with ACIN1 and SRSF2 in nuclear speckles (PubMed:20966198). {ECO:0000269|PubMed:16314458, ECO:0000269|PubMed:20966198}.
uniprot
proteins