TRMT112
entrez
51504
canonical
uniprot
Q9UI30
canonical
ensembl
ENSG00000173113
resolver
ensp
ENSP00000309433
resolver
ensp
ENSP00000438349
resolver
ensp
ENSP00000597097
resolver
ensp
ENSP00000635708
resolver
ensp
ENSP00000740058
resolver
genesymbol
TRMT112
resolver
hgnc
HGNC:26940
resolver
uniprot
B2R539
resolver
uniprot
J3KNG5
resolver
uniprot
Q3MHC7
resolver
uniprot
Q8N2Z4
resolver
uniprot_entry
TR112_HUMAN
resolver
uniprot_sec
B2R539
resolver
uniprot_sec
J3KNG5
resolver
uniprot_sec
Q3MHC7
resolver
uniprot_sec
Q8N2Z4
resolver
amino_acid_sequence
MKLLTHNLLSSHVRGVGSRGFPLRLQATEVRICPVEFNPNFVARMIPKVEWSAFLEAADNLRLIQVPKGPVEGYEENEEFLRTMHHLLLEVEVIEGTLQCPESGRMFPISRGIPNMLLSEEETES
uniprot
proteins
function
FUNCTION: Acts as an activator of both rRNA/tRNA and protein methyltransferases (PubMed:18539146, PubMed:20308323, PubMed:25851604, PubMed:31061526, PubMed:31328227, PubMed:31636962, PubMed:37283053). Together with methyltransferase BUD23, methylates the N(7) position of a guanine in 18S rRNA (PubMed:25851604). The heterodimer with N6AMT1/HEMK2 catalyzes N5-methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor (PubMed:18539146, PubMed:31061526, PubMed:31636962). The heterodimer with N6AMT1/HEMK2 also monomethylates 'Lys-12' of histone H4 (H4K12me1) (PubMed:31061526). The heterodimer with ALKBH8 catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA species (PubMed:20308323). Together with methyltransferase THUMPD3, catalyzes the formation of N(2)-methylguanosine at position 6 in a broad range of tRNA substrates and at position 7 of tRNA(Trp) (PubMed:34669960, PubMed:37283053). Involved in the pre-rRNA processing steps leading to small-subunit rRNA production (PubMed:25851604). Together with methyltransferase METTL5, specifically methylates the 6th position of adenine in position 1832 of 18S rRNA (PubMed:31328227, PubMed:33428944, PubMed:35033535, PubMed:37283053). {ECO:0000269|PubMed:18539146, ECO:0000269|PubMed:20308323, ECO:0000269|PubMed:25851604, ECO:0000269|PubMed:31061526, ECO:0000269|PubMed:31328227, ECO:0000269|PubMed:31636962, ECO:0000269|PubMed:33428944, ECO:0000269|PubMed:34669960, ECO:0000269|PubMed:37283053}.
uniprot
proteins
mass_dalton
14199
uniprot
proteins
mutagenesis
MUTAGEN 5; /note="T->A: Abolishes interaction with N6AMT1, METTL5, TRMT11, THUMPD3 and THUMPD2. Reduces interaction with BUD23 and ALKBH8. Reduces expression of exogenous TRMT112."; /evidence="ECO:0000269|PubMed:34948388"; MUTAGEN 5; /note="T->R: Loss of interaction with METTL5, THUMPD3, THUMPD2 and TRMT11."; /evidence="ECO:0000269|PubMed:37283053"; MUTAGEN 8; /note="L->D: Strongly reduced ability to promote N5-methylation of ETF1 together with HEMK2/N6AMT1."; /evidence="ECO:0000269|PubMed:31636962"; MUTAGEN 8; /note="L->W: Abolishes interaction with METTL5 and THUMPD3. Reduces interaction with ALKBH8, THUMPD2 and TRMT11. No effect on interaction with N6AMT1 and BUD23. No effect on expression of exogenous TRMT112."; /evidence="ECO:0000269|PubMed:34948388"; MUTAGEN 9; /note="L->D: Strongly reduced ability to promote N5-methylation of ETF1 together with HEMK2/N6AMT1."; /evidence="ECO:0000269|PubMed:31636962"; MUTAGEN 10; /note="S->F: Abolishes interaction with THUMPD2. Increases expression of exogenous TRMT112. No effect on interaction with N6AMT1, BUD23, METTL5, TRMT11, ALKBH8 and THUMPD3."; /evidence="ECO:0000269|PubMed:34948388"; MUTAGEN 45; /note="M->A: Abolishes interaction with METTL5 and THUMPD3. Reduces interaction with ALKBH8 and THUMPD2. No effect on interaction with N6AMT1, BUD23 and TRMT11. Reduces expression of exogenous TRMT112."; /evidence="ECO:0000269|PubMed:34948388"; MUTAGEN 48; /note="K->A: Abolishes interaction with THUMPD2 and THUMPD3. Reduces interaction with TRMT11, ALKBH8 and N6AMT1. No effect on interaction with BUD23 and METTL5. No effect on expression of exogenous TRMT112."; /evidence="ECO:0000269|PubMed:34948388"; MUTAGEN 50; /note="E->A: Increases interaction with METTL5. No effect on interaction with TRMT11, THUMPD2, THUMPD3, N6AMT1, BUD23 and ALKBH8. No effect on expression of exogenous TRMT112."; /evidence="ECO:0000269|PubMed:34948388"; MUTAGEN 92; /note="E->A: Reduces interaction with THUMPD2, THUMPD3, ALKBH8, TRMT11, N6AMT1 and BUD23. Increases interaction with METTL5. Reduces expression of exogenous TRMT112."; /evidence="ECO:0000269|PubMed:34948388"; MUTAGEN 107; /note="F->A: Abolishes interaction with BUD23, THUMPD2 and THUMPD3. Reduces interaction with TRMT11, N6AMT1, METTL5 and ALKBH8. Reduces expression of exogenous TRMT112."; /evidence="ECO:0000269|PubMed:34948388"; MUTAGEN 113; /note="I->D: Strongly reduced ability to promote N5-methylation of ETF1 together with HEMK2/N6AMT1."; /evidence="ECO:0000269|PubMed:31636962"; MUTAGEN 113; /note="I->F: Abolishes interaction with THUMPD2 and THUMPD3. Reduces interaction with N6AMT1, BUD23, TRMT11 and ALKBH8. Reduces expression of exogenous TRMT112. Increases interaction with METTL5."; /evidence="ECO:0000269|PubMed:34948388
uniprot
proteins
protein_family
TRM112 family
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
18539146
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20308323
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25851604
uniprot
proteins
pubmed
31061526
uniprot
proteins
pubmed
31328227
uniprot
proteins
pubmed
31632689
uniprot
proteins
pubmed
31636962
uniprot
proteins
pubmed
32217665
uniprot
proteins
pubmed
32969463
uniprot
proteins
pubmed
33428944
uniprot
proteins
pubmed
34669960
uniprot
proteins
pubmed
34948388
uniprot
proteins
pubmed
35033535
uniprot
proteins
pubmed
37283053
uniprot
proteins
sequence_length
125
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:25851604}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:25851604}. Note=Localizes to a polarized perinuclear structure, overlapping partially with the Golgi and lysosomes (PubMed:25851604). {ECO:0000269|PubMed:25851604}.
uniprot
proteins