GPR26
entrez
2849
canonical
uniprot
Q8NDV2
canonical
ensembl
ENSG00000154478
resolver
ensp
ENSP00000284674
resolver
enst
ENST00000284674
resolver
genesymbol
GPR26
resolver
hgnc
HGNC:4481
resolver
uniprot
Q2M2E2
resolver
uniprot_entry
GPR26_HUMAN
resolver
uniprot_sec
Q2M2E2
resolver
amino_acid_sequence
MNSWDAGLAGLLVGTMGVSLLSNALVLLCLLHSADIRRQAPALFTLNLTCGNLLCTVVNMPLTLAGVVAQRQPAGDRLCRLAAFLDTFLAANSMLSMAALSIDRWVAVVFPLSYRAKMRLRDAALMVAYTWLHALTFPAAALALSWLGFHQLYASCTLCSRRPDERLRFAVFTGAFHALSFLLSFVVLCCTYLKVLKVARFHCKRIDVITMQTLVLLVDLHPSVRERCLEEQKRRRQRATKKISTFIGTFLVCFAPYVITRLVELFSTVPIGSHWGVLSKCLAYSKAASDPFVYSLLRHQYRKSCKEILNRLLHRRSIHSSGLTGDSHSQNILPVSE
uniprot
proteins
function
FUNCTION: Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. {ECO:0000269|PubMed:17363172}.
uniprot
proteins
mass_dalton
37604
uniprot
proteins
mutagenesis
MUTAGEN 104; /note="R->A: No effect on constitutive activity; when associated with E-236."; /evidence="ECO:0000269|PubMed:17363172"; MUTAGEN 104; /note="R->Q,E: No effect on constitutive activity."; /evidence="ECO:0000269|PubMed:17363172"; MUTAGEN 104; /note="R->Q: No effect on constitutive activity; when associated with E-236."; /evidence="ECO:0000269|PubMed:17363172"; MUTAGEN 236; /note="R->A,Q: No effect on constitutive activity."; /evidence="ECO:0000269|PubMed:17363172"; MUTAGEN 236; /note="R->E: No effect on constitutive activity; when associated with A-104. No effect on constitutive activity; when associated with Q-104."; /evidence="ECO:0000269|PubMed:17363172
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17363172
uniprot
proteins
pubmed
18037267
uniprot
proteins
sequence_length
337
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 11..31; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 48..68; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 82..102; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 124..144; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 169..189; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 246..266; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 277..297; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins