Rbbp6
entrez
19647
canonical
uniprot
P97868
canonical
ensembl
ENSMUSG00000030779
resolver
ensp
ENSMUSP00000049528
resolver
ensp
ENSMUSP00000071519
resolver
ensp
ENSMUSP00000095670
resolver
ensp
ENSMUSP00000155989
resolver
enst
ENSMUST00000098062
resolver
genesymbol
Rbbp6
resolver
genesymbol_syn
P2pr
resolver
genesymbol_syn
Pact
resolver
uniprot
A0A0R4J165
resolver
uniprot
P70287
resolver
uniprot
Q3TTR9
resolver
uniprot
Q3TUM7
resolver
uniprot
Q3UMP7
resolver
uniprot
Q4U217
resolver
uniprot
Q7TT06
resolver
uniprot
Q8BNY8
resolver
uniprot
Q8R399
resolver
uniprot_entry
A0A0R4J165_MOUSE
resolver
uniprot_entry
RBBP6_MOUSE
resolver
uniprot_sec
P70287
resolver
uniprot_sec
Q3TTR9
resolver
uniprot_sec
Q3TUM7
resolver
uniprot_sec
Q3UMP7
resolver
uniprot_sec
Q4U217
resolver
uniprot_sec
Q7TT06
resolver
uniprot_sec
Q8BNY8
resolver
uniprot_sec
Q8R399
resolver
amino_acid_sequence
MSCVHYKFSSKLNYDTVTFDGLHISLCDLKKQIMGREKLKAADSDLQITNAQTKEEYTDDNALIPKNSSVIVRRIPIGGVKSTSKTYVISRTEPVMGTTKAIDDASASISLAQLTKTANLAEANASEEDKIKAMMSQSGHEYDPINYMKKTLVGPPPPSYTCFRCGKPGHYIKNCPTNGDKNFESGPRIKKSTGIPRSFMMEVKDPNMKGAMLTNTGKYAIPTIDAEAYAIGKKEKPPFLPEEPSSSSEEDDPIPDELLCLICKDIMTDAVVIPCCGNSYCDECIRTALLESDEHTCPTCHQNDVSPDALIANKFLRQAVNNFKNETGYTKRLRKQLPPPPPPVPPPRPLMQRNLQPLMRSPISRQQDPLMIPVTSSSAHSAPSISSLTSNPSALAPSVSGNPSSAPAPVPDITATVSISVHSEKSDGPFRDSDNKLLPAAALTSEHSKGASSIAITALMEEKGYQVPVLGTPSLLGQSLLHGQLIPTTGPVRINAARPGGGRPGWEHSNKLGYLVSPPQQIRRGERSCYRSINRGRHHSERSQRTQGPSLPATPVFVPVPPPPLYPPPPHTLPLPPGVPPPQFSPQFPPGQPPPAGYSVPPPGFPPAPANISTPWVSSGVQTAHSNTIPTTQAPPLSREEFYREQRRLKEEEKKKSKLDEFTNDFAKELMEYKKIQKERRRSFSRSKSPYSGSSYSRSSYTYSKSRSGSTRSRSYSRSFSRSHSRSYSRSPPYPRRGRGKSRNYRSRSRSHGYHRSRSRSPPYRRYHSRSRSPQAFRGQSPTKRNVPQGETEREYFNRYREVPPPYDIKAYYGRSVDFRDPFEKERYREWERKYREWYEKYYKGYAVGAQPRPSANREDFSPERLLPLNIRNSPFTRGRREDYAAGQSHRNRNLGGNYPEKLSTRDSHNAKDNPKSKEKESENVPGDGKGNKHKKHRKRRKGEESESFLNPELLETSRKCRESSGIDETKTDTLFVLPSRDDATPVRDEPMDAESITFKSVSDKDKREKDKPKVKSDKTKRKSDGSATAKKDNVLKPSKGPQEKVDGDREKSPRSEPPLKKAKEEATKIDSVKPSSSSQKDEKVTGTPRKAHSKSAKEHQEAKPAKDEKVKKDCSKDIKSEKPASKDEKAKKPEKNKLLDSKGEKRKRKTEEKSVDKDFESSSMKISKVEGTEIVKPSPKRKMEGDVEKLERTPEKDKIASSTTPAKKIKLNRETGKKIGNAENASTTKEPSEKLESTSSKIKQEKVKGKAKRKVAGSEGSSSTLVDYTSTSSTGGSPVRKSEEKTDTKRTVIKTMEEYNNDNTAPAEDVIIMIQVPQSKWDKDDFESEEEDVKTTQPIQSVGKPSSIIKNVTTKPSATAKYTEKESEQPEKLQKLPKEASHELMQHELRSSKGSASSEKGRAKDREHSGSEKDNPDKRKSGAQPDKESTVDRLSEQGHFKTLSQSSKETRTSEKHESVRGSSNKDFTPGRDKKVDYDSRDYSSSKRRDERGELARRKDSPPRGKESLSGQKSKLREERDLPKKGAESKKSNSSPPRDKKPHDHKAPYETKRPCEETKPVDKNSGKEREKHAAEARNGKESSGGKLPCIPNPPDPPMEKELAAGQVEKSAVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSESNVSVKEEEAVASISKDLKEKTTEKAKESLTVATASQPGADRSQSQSSPSVSPSRSHSPSGSQTRSHSSSASSAGSQDSKKKKKKKEKKKHKKHKKHKKHKKHAGADGDVEKSQKHKHKKKKAKKNKDKEKEKDDQKVRSVTV
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (By similarity). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53; may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth retardation (PubMed:17470788). Regulates DNA-replication and common fragile sites (CFS) stability in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359). {ECO:0000250|UniProtKB:Q7Z6E9, ECO:0000269|PubMed:17470788, ECO:0000269|PubMed:24726359}.
uniprot
proteins
mass_dalton
199587
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by NEK6. {ECO:0000250}.
uniprot
proteins
pubmed
12064457
uniprot
proteins
pubmed
12384997
uniprot
proteins
pubmed
14566974
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17470788
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
24726359
uniprot
proteins
pubmed
9010216
uniprot
proteins
pubmed
9037032
uniprot
proteins
sequence_length
1790
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Colocalizes with mitotic chromosomes. Co-localizes with NEK6 in the centrosome (By similarity). {ECO:0000250}.
uniprot
proteins