Camk2d
entrez
108058
canonical
uniprot
Q6PHZ2
canonical
ensembl
ENSMUSG00000053819
resolver
ensp
ENSMUSP00000063359
resolver
ensp
ENSMUSP00000102007
resolver
ensp
ENSMUSP00000102008
resolver
ensp
ENSMUSP00000102009
resolver
ensp
ENSMUSP00000102010
resolver
ensp
ENSMUSP00000129999
resolver
ensp
ENSMUSP00000133019
resolver
ensp
ENSMUSP00000143504
resolver
ensp
ENSMUSP00000143677
resolver
ensp
ENSMUSP00000203410
resolver
ensp
ENSMUSP00000203411
resolver
ensp
ENSMUSP00000203412
resolver
ensp
ENSMUSP00000203413
resolver
ensp
ENSMUSP00000203414
resolver
ensp
ENSMUSP00000203415
resolver
ensp
ENSMUSP00000203416
resolver
ensp
ENSMUSP00000203429
resolver
ensp
ENSMUSP00000203435
resolver
ensp
ENSMUSP00000203439
resolver
ensp
ENSMUSP00000203441
resolver
ensp
ENSMUSP00000203442
resolver
ensp
ENSMUSP00000203447
resolver
ensp
ENSMUSP00000203451
resolver
ensp
ENSMUSP00000203463
resolver
ensp
ENSMUSP00000203464
resolver
ensp
ENSMUSP00000203466
resolver
ensp
ENSMUSP00000203467
resolver
ensp
ENSMUSP00000203469
resolver
ensp
ENSMUSP00000203470
resolver
enst
ENSMUST00000106399
resolver
enst
ENSMUST00000163226
resolver
enst
ENSMUST00000171289
resolver
enst
ENSMUST00000200171
resolver
genesymbol
Camk2d
resolver
genesymbol_syn
Kiaa4163
resolver
uniprot
A0A0G2JGS4
resolver
uniprot
E9Q1T1
resolver
uniprot
E9Q1W0
resolver
uniprot
F6TPW1
resolver
uniprot
Q3UF87
resolver
uniprot
Q3UQH9
resolver
uniprot
Q5DTK4
resolver
uniprot
Q8CAC5
resolver
uniprot
Q8CCM0
resolver
uniprot
Q9CZE2
resolver
uniprot_entry
A0A0G2JGS4_MOUSE
resolver
uniprot_entry
E9Q1T1_MOUSE
resolver
uniprot_entry
E9Q1W0_MOUSE
resolver
uniprot_entry
F6TPW1_MOUSE
resolver
uniprot_entry
KCC2D_MOUSE
resolver
uniprot_entry
Q8CCM0_MOUSE
resolver
uniprot_sec
Q3UF87
resolver
uniprot_sec
Q3UQH9
resolver
uniprot_sec
Q5DTK4
resolver
uniprot_sec
Q8CAC5
resolver
uniprot_sec
Q9CZE2
resolver
activity_regulation
ACTIVITY REGULATION: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity.
uniprot
proteins
amino_acid_sequence
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAYIRLTQYMDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPTVPIKPPCIPNGKENFSGGTSLWQNI
uniprot
proteins
ec_number
2.7.11.17
uniprot
proteins
function
FUNCTION: Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport (PubMed:12676814, PubMed:15456698, PubMed:17124532). Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure (PubMed:12676814, PubMed:19179290, PubMed:19381018). Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808' (PubMed:20194790). In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction (PubMed:15793582). In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure (PubMed:17124532). Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). {ECO:0000269|PubMed:11972023, ECO:0000269|PubMed:12676814, ECO:0000269|PubMed:15456698, ECO:0000269|PubMed:15793582, ECO:0000269|PubMed:17124532, ECO:0000269|PubMed:19179290, ECO:0000269|PubMed:19381018, ECO:0000269|PubMed:20194790}.
uniprot
proteins
mass_dalton
56369
uniprot
proteins
post_translational_modification
PTM: Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
CaMK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10967556
uniprot
proteins
pubmed
11972023
uniprot
proteins
pubmed
12676814
uniprot
proteins
pubmed
15456698
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15793582
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17124532
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19179290
uniprot
proteins
pubmed
19381018
uniprot
proteins
pubmed
20194790
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
499
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Sarcoplasmic reticulum membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
uniprot
proteins