CLEC2A
entrez
387836
canonical
uniprot
Q6UVW9
canonical
ensembl
ENSG00000188393
resolver
ensp
ENSP00000339732
resolver
ensp
ENSP00000396163
resolver
genesymbol
CLEC2A
resolver
genesymbol_syn
KACL
resolver
hgnc
HGNC:24191
resolver
uniprot
A5Y4G5
resolver
uniprot
A9QKS2
resolver
uniprot
A9QKS3
resolver
uniprot_entry
CLC2A_HUMAN
resolver
uniprot_sec
A5Y4G5
resolver
uniprot_sec
A9QKS2
resolver
uniprot_sec
A9QKS3
resolver
amino_acid_sequence
MINPELRDGRADGFIHRIVPKLIQNWKIGLMCFLSIIITTVCIIMIATWSKHAKPVACSGDWLGVRDKCFYFSDDTRNWTASKIFCSLQKAELAQIDTQEDMEFLKRYAGTDMHWIGLSRKQGDSWKWTNGTTFNGWFEIIGNGSFAFLSADGVHSSRGFIDIKWICSKPKYFL
uniprot
proteins
function
FUNCTION: Membrane-bound protein expressed mainly on keratinocytes which acts as a ligand to stimulate the activating receptor NKp65/KLRF2, expressed on the surface of natural killer (NK) cells (PubMed:25510854). Facilitates thereby dedicated immune recognition of keratinocytes leading to natural killer cell mediated cytotoxicity (PubMed:20194751). Also plays a role in modulating the extent of T-cell expansion (PubMed:18550855). {ECO:0000269|PubMed:18550855, ECO:0000269|PubMed:20194751, ECO:0000269|PubMed:25510854}.
uniprot
proteins
mass_dalton
19972
uniprot
proteins
mutagenesis
MUTAGEN 78; /note="N->A: Partial loss of glycosylation."; /evidence="ECO:0000269|PubMed:25510854"; MUTAGEN 130; /note="N->A: Partial loss of glycosylation."; /evidence="ECO:0000269|PubMed:25510854"; MUTAGEN 143; /note="N->A: Partial loss of glycosylation."; /evidence="ECO:0000269|PubMed:25510854"; MUTAGEN 148; /note="F->A: Reduces affinity for KLRF2 40-fold."; /evidence="ECO:0000269|PubMed:23803857"; MUTAGEN 152; /note="D->A: No effect on affinity for KLRF2."; /evidence="ECO:0000269|PubMed:23803857"; MUTAGEN 155; /note="H->A: Slightly reduces affinity for KLRF2."; /evidence="ECO:0000269|PubMed:23803857"; MUTAGEN 157..158; /note="SR->AA: Reduces affinity for KLRF2 over 10'000-fold."; /evidence="ECO:0000269|PubMed:23803857"; MUTAGEN 160..161; /note="FI->AA: Reduces affinity for KLRF2 550-fold."; MUTAGEN 161; /note="I->K: Complete abrogation of KLRF2 binding."; /evidence="ECO:0000269|PubMed:25510854"; MUTAGEN 162; /note="D->A: Reduces affinity for KLRF2 360-fold."; /evidence="ECO:0000269|PubMed:23803857
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:20194751, ECO:0000269|PubMed:23803857}.
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
18046548
uniprot
proteins
pubmed
18550855
uniprot
proteins
pubmed
20194751
uniprot
proteins
pubmed
23803857
uniprot
proteins
pubmed
25510854
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
174
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18046548, ECO:0000269|PubMed:18550855}; Single-pass type II membrane protein {ECO:0000269|PubMed:18046548, ECO:0000269|PubMed:18550855}.
uniprot
proteins
transmembrane_region
TRANSMEM 28..48; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins