Prdx1
entrez
18477
canonical
uniprot
P35700
canonical
ensembl
ENSMUSG00000028691
resolver
ensp
ENSMUSP00000102078
resolver
ensp
ENSMUSP00000114159
resolver
enst
ENSMUST00000106470
resolver
enst
ENSMUST00000135573
resolver
genesymbol
Prdx1
resolver
genesymbol_syn
Msp23
resolver
genesymbol_syn
Paga
resolver
genesymbol_syn
Tdpx2
resolver
uniprot
Q3UBV4
resolver
uniprot
Q9CWI2
resolver
uniprot_entry
PRDX1_MOUSE
resolver
uniprot_sec
Q3UBV4
resolver
uniprot_sec
Q9CWI2
resolver
amino_acid_sequence
MSSGNAKIGYPAPNFKATAVMPDGQFKDISLSEYKGKYVVFFFYPLDFTFVCPTEIIAFSDRADEFKKLNCQVIGASVDSHFCHLAWINTPKKQGGLGPMNIPLISDPKRTIAQDYGVLKADEGISFRGLFIIDDKGILRQITINDLPVGRSVDEIIRLVQAFQFTDKHGEVCPAGWKPGSDTIKPDVNKSKEYFSKQK
uniprot
proteins
ec_number
1.11.1.24
uniprot
proteins
function
FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (PubMed:19766572). {ECO:0000250|UniProtKB:Q06830, ECO:0000269|PubMed:19766572}.
uniprot
proteins
mass_dalton
22176
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Thr-90 during the M-phase, which leads to a decrease in enzymatic activity. {ECO:0000250|UniProtKB:Q06830}.; PTM: Acetylation increases reducing activity and resistance to superoxidation. Deacetylated by HDAC6 which decreases reducing activity. {ECO:0000250|UniProtKB:Q06830}.
uniprot
proteins
protein_family
AhpC/Prx1 subfamily
uniprot
proteins
protein_family
Peroxiredoxin family
uniprot
proteins
pubmed
10548725
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19766572
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21969592
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
8089076
uniprot
proteins
pubmed
8360158
uniprot
proteins
sequence_length
199
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q06830}.
uniprot
proteins