Gzma
entrez
14938
canonical
uniprot
P11032
canonical
ensembl
ENSMUSG00000023132
resolver
ensp
ENSMUSP00000023897
resolver
genesymbol
Gzma
resolver
genesymbol_syn
Ctla-3
resolver
genesymbol_syn
Ctla3
resolver
genesymbol_syn
Mtsp-1
resolver
uniprot
P15118
resolver
uniprot
Q3U0N0
resolver
uniprot_entry
GRAA_MOUSE
resolver
uniprot_entry
Q3U0N0_MOUSE
resolver
uniprot_sec
P15118
resolver
amino_acid_sequence
MRNASGPRGPSLATLLFLLLIPEGGCERIIGGDTVVPHSRPYMALLKLSSNTICAGALIEKNWVLTAAHCNVGKRSKFILGAHSINKEPEQQILTVKKAFPYPCYDEYTREGDLQLVRLKKKATVNRNVAILHLPKKGDDVKPGTRCRVAGWGRFGNKSAPSETLREVNITVIDRKICNDEKHYNFHPVIGLNMICAGDLRGGKDSCNGDSGSPLLCDGILRGITSFGGEKCGDRRWPGVYTFLSDKHLNWIKKIMKGSV
uniprot
proteins
ec_number
3.4.21.78
uniprot
proteins
function
FUNCTION: Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse (PubMed:3555842). It cleaves after Lys or Arg (By similarity). Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity (By similarity). Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA (By similarity). {ECO:0000250|UniProtKB:P12544, ECO:0000269|PubMed:3555842}.
uniprot
proteins
mass_dalton
28599
uniprot
proteins
protein_family
Granzyme subfamily
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
1460043
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1639378
uniprot
proteins
pubmed
2422755
uniprot
proteins
pubmed
2976140
uniprot
proteins
pubmed
3260181
uniprot
proteins
pubmed
3292396
uniprot
proteins
pubmed
3533635
uniprot
proteins
pubmed
3555842
uniprot
proteins
sequence_length
260
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P12544}. Cytoplasmic granule {ECO:0000269|PubMed:3555842}. Note=Delivered into the target cell by perforin. {ECO:0000250|UniProtKB:P12544}.
uniprot
proteins