Mettl5
entrez
75422
canonical
uniprot
Q8K1A0
canonical
ensembl
ENSMUSG00000051730
resolver
ensp
ENSMUSP00000050907
resolver
ensp
ENSMUSP00000121474
resolver
ensp
ENSMUSP00000314800
resolver
ensp
ENSMUSP00000314805
resolver
ensp
ENSMUSP00000356167
resolver
enst
ENSMUST00000060447
resolver
enst
ENSMUST00000142127
resolver
genesymbol
Mettl5
resolver
uniprot
D6RCI3
resolver
uniprot
Q3UZW4
resolver
uniprot_entry
D6RCI3_MOUSE
resolver
uniprot_entry
METL5_MOUSE
resolver
uniprot_entry
Q3UZW4_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: rRNA N6-adenosine-methyltransferase activity is inhibited by zinc. {ECO:0000250|UniProtKB:Q9NRN9}.
uniprot
proteins
amino_acid_sequence
MKKLKLKELESRLQEVDGFEKPKLLLEQYPTRPHIAACMLYTIHNTYDDIENKAVADLGCGCGVLSIGAAMLGAGLCVGFDIDEDALEIFNKNVEEFELTNVDMIQCDVYSLSNRMSKLFDTVIMNPPFGTKNNKGTDMAFLKTALGMARTAVYSLHKSSTREHIQKKAAEWKVKIEIIAELRYDLPALYNFHKKKSVDIEVDLIRFSF
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Catalytic subunit of a heterodimer with TRMT112, which specifically methylates the 6th position of adenine in position 1832 of 18S rRNA (PubMed:32783360, PubMed:35033535). N6-methylation of adenine(1832) in 18S rRNA resides in the decoding center of 18S rRNA and is required for translation and embryonic stem cells (ESCs) pluripotency and differentiation (PubMed:32217665, PubMed:32783360). {ECO:0000269|PubMed:32217665, ECO:0000269|PubMed:32783360, ECO:0000269|PubMed:35033535}.
uniprot
proteins
mass_dalton
23662
uniprot
proteins
mutagenesis
MUTAGEN 126..129; /note="NPPF->APPA: Abolished rRNAN6-adenosine-methyltransferase activity."; /evidence="ECO:0000269|PubMed:32783360
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
protein_family
PrmA family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
31564433
uniprot
proteins
pubmed
32217665
uniprot
proteins
pubmed
32783360
uniprot
proteins
pubmed
35033535
uniprot
proteins
sequence_length
209
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NRN9}. Presynapse {ECO:0000250|UniProtKB:Q9NRN9}. Postsynapse {ECO:0000250|UniProtKB:Q9NRN9}.
uniprot
proteins