MTRES1
entrez
51250
canonical
uniprot
Q9P0P8
canonical
ensembl
ENSG00000130349
resolver
ensp
ENSP00000310951
resolver
ensp
ENSP00000384867
resolver
ensp
ENSP00000485698
resolver
ensp
ENSP00000548946
resolver
ensp
ENSP00000548947
resolver
ensp
ENSP00000548948
resolver
ensp
ENSP00000548949
resolver
ensp
ENSP00000548950
resolver
ensp
ENSP00000548951
resolver
ensp
ENSP00000548953
resolver
ensp
ENSP00000548954
resolver
ensp
ENSP00000548955
resolver
ensp
ENSP00000548956
resolver
ensp
ENSP00000548957
resolver
ensp
ENSP00000548958
resolver
ensp
ENSP00000583982
resolver
ensp
ENSP00000583983
resolver
ensp
ENSP00000629666
resolver
ensp
ENSP00000629667
resolver
ensp
ENSP00000629668
resolver
ensp
ENSP00000629669
resolver
enst
ENST00000311381
resolver
enst
ENST00000405204
resolver
enst
ENST00000625458
resolver
enst
ENST00000878887
resolver
enst
ENST00000878888
resolver
enst
ENST00000878889
resolver
enst
ENST00000878890
resolver
enst
ENST00000878891
resolver
enst
ENST00000878892
resolver
enst
ENST00000878894
resolver
enst
ENST00000878895
resolver
enst
ENST00000878896
resolver
enst
ENST00000878897
resolver
enst
ENST00000878898
resolver
enst
ENST00000878899
resolver
enst
ENST00000913923
resolver
enst
ENST00000913924
resolver
enst
ENST00000959607
resolver
enst
ENST00000959608
resolver
enst
ENST00000959609
resolver
enst
ENST00000959610
resolver
genesymbol
MTRES1
resolver
genesymbol_syn
C6orf203
resolver
hgnc
HGNC:17971
resolver
uniprot
A0A0D9SEI0
resolver
uniprot
B3KRG9
resolver
uniprot_entry
A0A0D9SEI0_HUMAN
resolver
uniprot_entry
MRES1_HUMAN
resolver
uniprot_sec
B3KRG9
resolver
amino_acid_sequence
MAMASVKLLAGVLRKPDAWIGLWGVLRGTPSSYKLCTSWNRYLYFSSTKLRAPNYKTLFYNIFSLRLPGLLLSPECIFPFSVRLKSNIRSTKSTKKSLQKVDEEDSDEESHHDEMSEQEEELEDDPTVVKNYKDLEKAVQSFRYDVVLKTGLDIGRNKVEDAFYKGELRLNEEKLWKKSRTVKVGDTLDLLIGEDKEAGTETVMRILLKKVFEEKTESEKYRVVLRRWKSLKLPKKRMSK
uniprot
proteins
function
FUNCTION: Mitochondrial RNA-binding protein involved in mitochondrial transcription regulation. Functions as a protective factor to maintain proper mitochondrial RNA level during stress. Acts at the transcription level and its protective function depends on its RNA binding ability (PubMed:31226201). Part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation (PubMed:31396629, PubMed:33243891). As heterodimer with MTRF, ejects the unfinished nascent chain and peptidyl transfer RNA (tRNA), respectively, from stalled ribosomes. Recruitment of mitoribosome biogenesis factors to these quality control intermediates suggests additional roles for MTRES1 and MTRF during mitoribosome rescue (PubMed:33243891). {ECO:0000269|PubMed:31226201, ECO:0000269|PubMed:31396629, ECO:0000269|PubMed:33243891}.
uniprot
proteins
mass_dalton
27941
uniprot
proteins
mutagenesis
MUTAGEN 143; /note="R->A: Decreased RNA-binding; when associated with A-145; A-149: A-156 and A-158. Does not rescue diminished mitochondrial transcription induced by EtBr; when associated with A-145; A-149: A-156 and A-158."; /evidence="ECO:0000269|PubMed:31226201"; MUTAGEN 145; /note="D->A: Decreased RNA-binding; when associated with A-143; A-149: A-156 and A-158. Does not rescue diminished mitochondrial transcription induced by EtBr; when associated with A-143; A-149: A-156 and A-158."; /evidence="ECO:0000269|PubMed:31226201"; MUTAGEN 149; /note="K->A: Decreased RNA-binding; when associated with A-143; A-145: A-156 and A-158. Does not rescue diminished mitochondrial transcription induced by EtBr; when associated with A-143; A-149: A-156 and A-158."; /evidence="ECO:0000269|PubMed:31226201"; MUTAGEN 156; /note="R->A: Decreased RNA-binding; when associated with A-143; A-145: A-149 and A-158. Does not rescue diminished mitochondrial transcription induced by EtBr; when associated with A-143; A-145: A-149 and A-158."; /evidence="ECO:0000269|PubMed:31226201"; MUTAGEN 158; /note="K->A: Decreased RNA-binding; when associated with A-143; A-145: A-149 and A-156. Does not rescue diminished mitochondrial transcription induced by EtBr; when associated with A-143; A-145: A-149 and A-156."; /evidence="ECO:0000269|PubMed:31226201
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
31226201
uniprot
proteins
pubmed
31396629
uniprot
proteins
pubmed
33243891
uniprot
proteins
sequence_length
240
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:31226201, ECO:0000269|PubMed:31396629}.
uniprot
proteins