TMEM109
entrez
79073
canonical
uniprot
Q9BVC6
canonical
ensembl
ENSG00000110108
resolver
ensp
ENSP00000227525
resolver
ensp
ENSP00000443990
resolver
ensp
ENSP00000520520
resolver
ensp
ENSP00000558831
resolver
ensp
ENSP00000558832
resolver
ensp
ENSP00000558833
resolver
ensp
ENSP00000558834
resolver
ensp
ENSP00000558835
resolver
ensp
ENSP00000558836
resolver
enst
ENST00000227525
resolver
enst
ENST00000536171
resolver
enst
ENST00000715796
resolver
enst
ENST00000888772
resolver
enst
ENST00000888773
resolver
enst
ENST00000888774
resolver
enst
ENST00000888775
resolver
enst
ENST00000888776
resolver
enst
ENST00000888777
resolver
genesymbol
TMEM109
resolver
hgnc
HGNC:28771
resolver
uniprot_entry
TM109_HUMAN
resolver
amino_acid_sequence
MAASSISSPWGKHVFKAILMVLVALILLHSALAQSRRDFAPPGQQKREAPVDVLTQIGRSVRGTLDAWIGPETMHLVSESSSQVLWAISSAISVAFFALSGIAAQLLNALGLAGDYLAQGLKLSPGQVQTFLLWGAGALVVYWLLSLLLGLVLALLGRILWGLKLVIFLAGFVALMRSVPDPSTRALLLLALLILYALLSRLTGSRASGAQLEAKVRGLERQVEELRWRQRRAAKGARSVEEE
uniprot
proteins
function
FUNCTION: Functions as a voltage-gated monoatomic cation channel permeable to both potassium and calcium (By similarity). Plays a role in the cellular response to DNA damage (PubMed:23542032). {ECO:0000250|UniProtKB:O77751, ECO:0000269|PubMed:23542032}.
uniprot
proteins
mass_dalton
26210
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23542032
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
243
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus outer membrane {ECO:0000250|UniProtKB:O77751}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O77751}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O77751}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O77751}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:O77751}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O77751}.
uniprot
proteins
transmembrane_region
TRANSMEM 84..104; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 136..156; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 186..205; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins