Ivns1abp
entrez
117198
canonical
uniprot
Q920Q8
canonical
ensembl
ENSMUSG00000023150
resolver
ensp
ENSMUSP00000023918
resolver
ensp
ENSMUSP00000095150
resolver
ensp
ENSMUSP00000107518
resolver
genesymbol
Ivns1abp
resolver
genesymbol_syn
Kiaa0850
resolver
genesymbol_syn
Nd1
resolver
genesymbol_syn
Nd1L
resolver
genesymbol_syn
Nd1S
resolver
genesymbol_syn
Ns1
resolver
genesymbol_syn
Ns1bp
resolver
uniprot
Q06BK5
resolver
uniprot
Q06BK6
resolver
uniprot
Q3TXI1
resolver
uniprot
Q3UJE3
resolver
uniprot
Q3UJS1
resolver
uniprot
Q3UKH9
resolver
uniprot
Q3UMK9
resolver
uniprot
Q6ZQ34
resolver
uniprot
Q99KN0
resolver
uniprot
Q9D978
resolver
uniprot_entry
NS1BP_MOUSE
resolver
uniprot_entry
Q06BK5_MOUSE
resolver
uniprot_sec
Q06BK6
resolver
uniprot_sec
Q3TXI1
resolver
uniprot_sec
Q3UJE3
resolver
uniprot_sec
Q3UJS1
resolver
uniprot_sec
Q3UKH9
resolver
uniprot_sec
Q3UMK9
resolver
uniprot_sec
Q6ZQ34
resolver
uniprot_sec
Q99KN0
resolver
uniprot_sec
Q9D978
resolver
amino_acid_sequence
MIPNGYLMFEDENFIESSVAKLNALRKSGQFCDVRLQVCGHEMLAHRAVLACCSPYLFEIFNSDSDPHGVSHVKLDDLNPEAVEVLLNYAYTAQLKADKELVKDVYSAAKKLKMDRVKQVCGDYLLSRMDVTSCISYRNFASCMGDSRLLNKVDAYIQEHLLQISEEEEFLKLPRLKLEVMLEDNVCLPSNGKLYTKVINWVQRSIWENGDSLEELMEEVQTLYYSADHKLLDGNPLDGQAEVFGSDDDHIQFVQKKPPRENGHKQISGSSTGCLSSPNASMQSPKHEWKIVASEKTSNNTYLCLAVLDSTFCVIFLHGRNSPQSSPTSTPKLSKSLSFEMQPDELLEKPMSPMQYARSGLGTAEMNGKLIAAGGYNREECLRTVECYDPHTDHWSFLAPMRTPRARFQMAVLMGQLYVVGGSNGHSDDLSCGEMYDPNIDDWTPVPELRTNRCNAGVCALNGKLYIVGGSDPYGQKGLKNCDVFDPVTKSWTSCAPLNIRRHQSAVCELGGYLYIIGGAESWNCLNTVERYNPENNTWTLIAPMNVARRGAGVAVLDGKLFVGGGFDGSHAISCVEMYDPTRNEWKMMGNMTSPRSNAGITTVGNTIYAVGGFDGNEFLNTVEVYNPQSNEWSPYTKIFQF
uniprot
proteins
function
FUNCTION: Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats (PubMed:12213805, PubMed:16317045). Protects cells from cell death induced by actin destabilization (PubMed:16952015). Functions as a modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription (By similarity). In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors (By similarity). Inhibits pre-mRNA splicing (in vitro) (By similarity). May play a role in mRNA nuclear export (By similarity). {ECO:0000250|UniProtKB:Q9Y6Y0, ECO:0000269|PubMed:12213805, ECO:0000269|PubMed:16317045, ECO:0000269|PubMed:16952015}.; FUNCTION: [Isoform 2]: May play a role in cell cycle progression in the nucleus. {ECO:0000269|PubMed:15684717}.
uniprot
proteins
mass_dalton
71581
uniprot
proteins
protein_family
BTB-kelch protein family
uniprot
proteins
pubmed
11418182
uniprot
proteins
pubmed
12213805
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15485691
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15684717
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16317045
uniprot
proteins
pubmed
16952015
uniprot
proteins
pubmed
17016628
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
642
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12213805}. Note=Associated with actin filaments. {ECO:0000269|PubMed:12213805}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000269|PubMed:15684717}. Note=Not associated with actin filaments. {ECO:0000269|PubMed:15684717}.
uniprot
proteins