KHDRBS2
entrez
202559
canonical
uniprot
Q5VWX1
canonical
ensembl
ENSG00000112232
resolver
ensp
ENSP00000281156
resolver
ensp
ENSP00000520654
resolver
enst
ENST00000281156
resolver
enst
ENST00000718012
resolver
genesymbol
KHDRBS2
resolver
genesymbol_syn
SLM1
resolver
hgnc
HGNC:18114
resolver
uniprot
A8K7M8
resolver
uniprot
Q8N4I4
resolver
uniprot
Q8TCZ4
resolver
uniprot_entry
KHDR2_HUMAN
resolver
uniprot_sec
A8K7M8
resolver
uniprot_sec
Q8N4I4
resolver
uniprot_sec
Q8TCZ4
resolver
amino_acid_sequence
MEEEKYLPELMAEKDSLDPSFVHASRLLAEEIEKFQGSDGKKEDEEKKYLDVISNKNIKLSERVLIPVKQYPKFNFVGKLLGPRGNSLKRLQEETGAKMSILGKGSMRDKAKEEELRKSGEAKYAHLSDELHVLIEVFAPPGEAYSRMSHALEEIKKFLVPDYNDEIRQEQLRELSYLNGSEDSGRGRGIRGRGIRIAPTAPSRGRGGAIPPPPPPGRGVLTPRGSTVTRGALPVPPVARGVPTPRARGAPTVPGYRAPPPPAHEAYEEYGYDDGYGGEYDDQTYETYDNSYATQTQSVPEYYDYGHGVSEDAYDSYAPEEWATTRSSLKAPPQRSARGGYREHPYGRY
uniprot
proteins
function
FUNCTION: RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. Binds both poly(A) and poly(U) homopolymers. Phosphorylation by PTK6 inhibits its RNA-binding ability (By similarity). Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. Can regulate alternative splicing of NRXN1 in the laminin G-like domain 6 containing the evolutionary conserved neurexin alternative spliced segment 4 (AS4) involved in neurexin selective targeting to postsynaptic partners. Regulates cell-type specific alternative splicing of NRXN1 at AS4 and acts synergystically with SAM68 in exon skipping. In contrast acts antagonistically with SAM68 in NRXN3 exon skipping at AS4. Its phosphorylation by FYN inhibits its ability to regulate splice site selection. May function as an adapter protein for Src kinases during mitosis. {ECO:0000250|UniProtKB:Q920F3, ECO:0000250|UniProtKB:Q9WU01}.
uniprot
proteins
mass_dalton
38927
uniprot
proteins
post_translational_modification
PTM: Methylated. {ECO:0000269|PubMed:12529443}.; PTM: Tyrosine phosphorylated by FYN, PTK6 and SRC. Tyrosine phosphorylated by SRC during mitosis (By similarity). {ECO:0000250|UniProtKB:Q9WU01}.
uniprot
proteins
protein_family
KHDRBS family
uniprot
proteins
pubmed
12529443
uniprot
proteins
pubmed
12549823
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19282290
uniprot
proteins
sequence_length
349
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9WU01}.
uniprot
proteins