Gnat2
entrez
14686
canonical
uniprot
P50149
canonical
ensembl
ENSMUSG00000009108
resolver
ensp
ENSMUSP00000053818
resolver
ensp
ENSMUSP00000238371
resolver
enst
ENSMUST00000058669
resolver
genesymbol
Gnat2
resolver
uniprot
A2AE33
resolver
uniprot_entry
A2AE33_MOUSE
resolver
uniprot_entry
GNAT2_MOUSE
resolver
amino_acid_sequence
MGSGISAEDKELARRSKELEKKLQEDADKEAKTVKLLLLGAGESGKSTIVKQMKIIHQDGYSPEECLEFKSVIYGNVLQSILAIIRAMSTLGIDYAEPSCADAGRQLNNLADSTEEGTMPPELVDVIRKLWKDGGVQACFDRAAEFQLNDSASYYLNQLDRITDPNYLPNEQDVLRSRVKTTGIIETKFSVKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFCAALSAYDMVLVEDDEVNRMHESLHLFNSICNHKFFAATSIVLFLNKKDLFEEKIKKVHLSICFPEYDGNNSYEDAGNYIKSQFLDLNMRKDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Alpha subunit of the heterotrimeric guanine nucleotide-binding protein (G protein) that transduces signals from the G protein-coupled cone photoreceptors (blue, green and red cones) (By similarity). Functions as a GTPase, cycling between an active GTP-bound state and an inactive GDP-bound state. Upon photoactivation, cone photoreceptors promote GDP release and GTP binding. In its active state, GNAT2 stimulates downstream effectors, including the cone cGMP-phosphodiesterase (PDE6) complex, to mediate the phototransduction cascade. Activation of the PDE6 complex occurs through binding and repositioning of the inhibitory PDE6 gamma subunits (PDE6H), thereby promoting catalytic activity (By similarity). {ECO:0000250|UniProtKB:P04695, ECO:0000250|UniProtKB:P19087}.
uniprot
proteins
mass_dalton
40118
uniprot
proteins
protein_family
G(i/o/t/z) subfamily
uniprot
proteins
protein_family
G-alpha family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8013366
uniprot
proteins
sequence_length
354
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:P19087}. Photoreceptor inner segment {ECO:0000250|UniProtKB:P19087}.
uniprot
proteins