Jade1
entrez
269424
canonical
uniprot
Q6ZPI0
canonical
ensembl
ENSMUSG00000025764
resolver
ensp
ENSMUSP00000026865
resolver
ensp
ENSMUSP00000127113
resolver
ensp
ENSMUSP00000128152
resolver
ensp
ENSMUSP00000131441
resolver
genesymbol
Jade1
resolver
genesymbol_syn
Kiaa1807
resolver
genesymbol_syn
Phf17
resolver
uniprot
Q6IE84
resolver
uniprot
Q8C7S6
resolver
uniprot
Q8CFM2
resolver
uniprot
Q8R362
resolver
uniprot_entry
JADE1_MOUSE
resolver
uniprot_sec
Q6IE84
resolver
uniprot_sec
Q8C7S6
resolver
uniprot_sec
Q8CFM2
resolver
uniprot_sec
Q8R362
resolver
amino_acid_sequence
MKRGRLPSSSEDSDDNGSLSTTWSQHSRSQHGRSSTCSRPEDRKPSEVFRTDLITAMKLHDSYQLNPDDYYVLADPWRQEWEKGVQVPVSPGTIPQPVARVVSEEKSLMFIRPKKYIASSGSEPPALGYVDIRTLADSVCRYDLNDMDAAWLEVTNEEFKEMGMPELDEYTMERVLEEFEQRCYDNMNHAIETEEGLGIEYDEDVVCDVCQSPDGEDGNEMVFCDKCNICVHQACYGILKVPEGSWLCRTCALGVQPKCLLCPKKGGAMKPTRSGTKWVHVSCALWIPEVSIGSPEKMEPITKVSHIPSSRWALVCSLCNEKFGASIQCSVKNCRTAFHVTCAFDRGLEMKTILAENDEVKFKSYCPKHSSHRKPEEGLGEGAAQENGAPESSPQSPLEPYGSLEPNREEAHRVSVRKQKLQQLEDEFYTFVNLLDVARALRLPEEVVDFLYQYWKLKRKINFNKPLITPKKDEEDNLAKREQDVLFRRLQLFTHLRQDLERVRNLTYMVTRREKIKRSVCKVQEQIFTQYTKLLEQEKVSGVPSSCSSALENMLFFNSPSVGPNAPKIEDLKWHSAFFRKQMGTSLVHPLKKSHKRDAVQNSSGTEGKTSHKQPGLCGRREGLEVSESLLSLEKTFAEARLLSSAQQKNGVVTPDHGKRRDNRFHCDLVKGDLKDKSFKQSHKPLRSTDTSQRHLDNTRAATSPGVGQSAPGTRKEIVPKCNGSLVKVPITPASPVKSWGGFRIPKKGERQQQGEAHDGACHQHSDCSHLGVSRAPAKERAKSRLRADSENDGYAPDGEMSDSESEASEKKCIHASSTISRRTDIIRRSILAS
uniprot
proteins
function
FUNCTION: Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity. Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation. May also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function. {ECO:0000250|UniProtKB:Q6IE81}.
uniprot
proteins
mass_dalton
93897
uniprot
proteins
protein_family
JADE family
uniprot
proteins
pubmed
12169691
uniprot
proteins
pubmed
14612400
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
834
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6IE81}. Chromosome {ECO:0000250|UniProtKB:Q6IE81}. Cytoplasm {ECO:0000250|UniProtKB:Q6IE81}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q6IE81}. Note=Localizes to the ciliary transition zone. {ECO:0000250|UniProtKB:Q6IE81}.
uniprot
proteins