JTB
entrez
10899
canonical
uniprot
O76095
canonical
ensembl
ENSG00000143543
resolver
ensp
ENSP00000271843
resolver
genesymbol
JTB
resolver
hgnc
HGNC:6201
resolver
uniprot
O95442
resolver
uniprot
Q6IB19
resolver
uniprot
Q9P0Q4
resolver
uniprot_entry
JTB_HUMAN
resolver
uniprot_sec
O95442
resolver
uniprot_sec
Q6IB19
resolver
uniprot_sec
Q9P0Q4
resolver
amino_acid_sequence
MLAGAGRPGLPQGRHLCWLLCAFTLKLCQAEAPVQEEKLSASTSNLPCWLVEEFVVAEECSPCSNFRAKTTPECGPTGYVEKITCSSSKRNEFKSCRSALMEQRLFWKFEGAVVCVALIFACLVIIRQRQLDRKALEKVRKQIESI
uniprot
proteins
function
FUNCTION: Required for normal cytokinesis during mitosis. Plays a role in the regulation of cell proliferation. May be a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Increases AURKB activity. Inhibits apoptosis induced by TGFB1 (By similarity). Overexpression induces swelling of mitochondria and reduces mitochondrial membrane potential (By similarity). {ECO:0000250, ECO:0000269|PubMed:21225229}.
uniprot
proteins
mass_dalton
16358
uniprot
proteins
protein_family
JTB family
uniprot
proteins
pubmed
10321732
uniprot
proteins
pubmed
10762645
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17369841
uniprot
proteins
pubmed
21225229
uniprot
proteins
pubmed
22079049
uniprot
proteins
sequence_length
146
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Mitochondrion {ECO:0000250}. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Note=Detected at the centrosome and along spindle fibers during prophase and metaphase. Detected at the midbody during telophase.
uniprot
proteins
transmembrane_region
TRANSMEM 106..126; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins