Aldh7a1
entrez
291450
canonical
uniprot
Q64057
canonical
ensembl
ENSRNOG00000014645
resolver
ensp
ENSRNOP00000020325
resolver
enst
ENSRNOT00000020325
resolver
genesymbol
Aldh7a1
resolver
genesymbol_syn
Ald7a1
resolver
uniprot_entry
AL7A1_RAT
resolver
amino_acid_sequence
MLRLARPLCVQTVKASKLSRLWSRPAALMSTLLIHHPQYAWLQDLGLREDNEGVFNGSWGGRGEVITTYCPANNEPIARVRQASMKDYEETIGKAKKAWNIWADIPAPKRGEIVRKIGDALREKIQLLGRLVSLEMGKILVEGIGEVQEYVDVCDYAAGLSRMIGGPTLPSERPGHALMEQWNPLGLVGIITAFNFPVAVFGWNNAIALITGNVCLWKGAPTTSLVSIAVTKIIAKVLEDNLLPGAICSLTCGGADMGTAMARDERVNLLSFTGSTQVGKQVALMVQERFGKSLLELGGNNAIIAFEDADLSLVLPSALFAAVGTAGQRCTTVRRLFLHESIHDEVVDRLKNAYSQIRVGNPWDPNILYGPLHTKQAVSMFVQAVEEAKKEGGTVVYGGKVMDHPGNYVEPTIVTGLVHDAPIVHKETFAPILYVFKFKNEEEVFEWNNEVKQGLSSSIFTKDLGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRESGSDAWKQYMRRSTCTINYSTALPLAQGIKFQ
uniprot
proteins
ec_number
1.2.1.3
uniprot
proteins
ec_number
1.2.1.31
uniprot
proteins
ec_number
1.2.1.8
uniprot
proteins
function
FUNCTION: Aldehyde dehydrogenase enzyme that mediates important protective effects. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism in the brain by mediating the conversion of L-aminoadipate-semialdehyde ((S)-2-amino-6-oxohexanoate) to L-2-aminoadipate. Acts as a key inhibitor of ferroptosis both by generating membrane NADH and decreasing the level of reactive aldehydes. Recruited to plasma membrane in response to ferroptotic stress and phosphorylation by AMPK, generating membrane NADH to support AIFM2/FSP1 activity, an essential ferroptosis suppressor protein. Also directly inhibits ferroptosis by decreasing lipid peroxidation via consumption of reactive aldehydes, such as 4-hydroxynonenal (4-HNE) and malonaldehyde. Also acts as a regulator of cellular energy homeostasis in response to cellular energy stress, such as starvation and hypoxia, by inhibiting COPI-mediated intracellular transport, thereby reducing cellular energy consumption. Involved in cellular defense against hyperosmotic stress by metabolizing betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. {ECO:0000250|UniProtKB:P49419}.
uniprot
proteins
mass_dalton
58749
uniprot
proteins
pathway_participation
PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. {ECO:0000250|UniProtKB:P49419}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by AMPK in response to cellular stress, such as hypoxia or ferroptotic stress, promotes membrane localization and generation of membrane NADH. {ECO:0000250|UniProtKB:P49419}.
uniprot
proteins
protein_family
Aldehyde dehydrogenase family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
8088832
uniprot
proteins
pubmed
9417906
uniprot
proteins
sequence_length
539
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P49419}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P49419}. Cell membrane {ECO:0000250|UniProtKB:P49419}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P49419}. Nucleus {ECO:0000250|UniProtKB:P49419}. Note=Translocates to membranes in response to cellular stress and phosphorylation by AMPK. {ECO:0000250|UniProtKB:P49419}.
uniprot
proteins