Peli3
entrez
240518
canonical
uniprot
Q8BXR6
canonical
ensembl
ENSMUSG00000024901
resolver
ensp
ENSMUSP00000025834
resolver
ensp
ENSMUSP00000113193
resolver
ensp
ENSMUSP00000239451
resolver
ensp
ENSMUSP00000239464
resolver
enst
ENSMUST00000025834
resolver
enst
ENSMUST00000120475
resolver
genesymbol
Peli3
resolver
uniprot
A0A0R4J057
resolver
uniprot
D3Z6V8
resolver
uniprot
Q8K329
resolver
uniprot_entry
A0A0R4J057_MOUSE
resolver
uniprot_entry
D3Z6V8_MOUSE
resolver
uniprot_entry
PELI3_MOUSE
resolver
uniprot_sec
Q8K329
resolver
amino_acid_sequence
MVLEGNPDVGSPRTSDLQHPGSQGSCILSCPGEEALAGEEPIKYGELIVLGYNGCLASGDKGRRRSRLALSRRPHANGVKPDVMHHISTPLVSKALSNRGQHSISFTLSRSHSVIVEYTHDSDKDMFQIGRSTENMIDFVVTDTSPGGGATEGPSAQSTISRYACRILCDRRPPYTARIYAAGFDASSNIFLGERAAKWRTPDGLMDGLTTNGVLVMHPAGGFSEDSAPGVWREISVCGNVYTLRDSRSAQQRGKLVENESNVLQDGSLIDLCGATLLWRTPAGLLRAPTLKQLEAQRQEANAARPQCPVGLSTLAFPSPARGRTAPDKQQPWVYVRCGHVHGYHGWGCRRERGPQERECPLCRLVGPYVPLWLGQEAGLCLDPGPPSHAFAPCGHVCSEKTARYWAQTPLPHGTHAFHAACPFCGAWLTGELGCVRLIFQGPLD
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins (PubMed:23892723). Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6 (By similarity). Mediates 'Lys-63'-linked polyubiquitination of IRAK1. Can activate AP1/JUN and ELK1 (By similarity). Acts as a regulator of innate immunity by mediating 'Lys-63'-linked polyubiquitination of RIPK2 downstream of NOD1 and NOD2, thereby transforming RIPK2 into a scaffolding protein for downstream effectors, ultimately leading to activation of the NF-kappa-B and MAP kinases signaling (PubMed:23892723). Catalyzes 'Lys-63'-linked polyubiquitination of RIPK2 in parallel of XIAP (PubMed:23892723). {ECO:0000250|UniProtKB:Q8N2H9, ECO:0000269|PubMed:23892723}.
uniprot
proteins
mass_dalton
48168
uniprot
proteins
mutagenesis
MUTAGEN 131; /note="R->A: Abolished ability to regulate the NOD2 signaling; when associated with A-161."; /evidence="ECO:0000269|PubMed:23892723"; MUTAGEN 161; /note="S->A: Abolished ability to regulate the NOD2 signaling; when associated with A-131."; /evidence="ECO:0000269|PubMed:23892723"; MUTAGEN 360..363; /note="CPLC->APLA: Abolished E3 ubiquitin ligase activity and ability to regulate the NOD2 signaling."; /evidence="ECO:0000269|PubMed:23892723
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:23892723}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by IRAK1 enhancing its E3 ligase activity. {ECO:0000250|UniProtKB:Q8N2H9}.
uniprot
proteins
protein_family
Pellino family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23892723
uniprot
proteins
sequence_length
445
uniprot
proteins