Timp1
entrez
116510
canonical
uniprot
P30120
canonical
ensembl
ENSRNOG00000010208
resolver
ensembl
ENSRNOG00055016390
resolver
ensembl
ENSRNOG00060020641
resolver
ensembl
ENSRNOG00065020279
resolver
ensp
ENSRNOP00000013745
resolver
ensp
ENSRNOP00055022317
resolver
ensp
ENSRNOP00060029429
resolver
ensp
ENSRNOP00065027434
resolver
enst
ENSRNOT00000013745
resolver
enst
ENSRNOT00055027786
resolver
enst
ENSRNOT00060035770
resolver
enst
ENSRNOT00065034257
resolver
genesymbol
Timp1
resolver
genesymbol_syn
Timp-1
resolver
uniprot
P70533
resolver
uniprot
Q53YM7
resolver
uniprot_entry
TIMP1_RAT
resolver
uniprot_sec
P70533
resolver
uniprot_sec
Q53YM7
resolver
amino_acid_sequence
MAPFASLASGILLLLSLIASSKACSCAPTHPQTAFCNSDLVIRAKFMGSPEIIETTLYQRYEIKMTKMLKGFDAVGNATGFRFAYTPAMESLCGYVHKSQNRSEEFLIAGRLRNGNLHITACSFLVPWHNLSPAQQKAFVKTYSAGCGVCTVFPCSAIPCKLESDSHCLWTDQILMGSEKGYQSDHFACLPRNPDLCTWQYLGVSMTRSLPLAKAEA
uniprot
proteins
function
FUNCTION: Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling. Also stimulates steroidogenesis by Leydig and ovarian granuloma cells; procathepsin L is required for maximal activity. {ECO:0000269|PubMed:1309971, ECO:0000269|PubMed:7777858}.
uniprot
proteins
mass_dalton
23794
uniprot
proteins
post_translational_modification
PTM: The activity of TIMP1 is dependent on the presence of disulfide bonds. {ECO:0000250}.; PTM: N-glycosylated. {ECO:0000269|PubMed:1309971}.
uniprot
proteins
protein_family
Protease inhibitor I35 (TIMP) family
uniprot
proteins
pubmed
1309971
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7777858
uniprot
proteins
pubmed
7926820
uniprot
proteins
pubmed
8707259
uniprot
proteins
sequence_length
217
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1309971, ECO:0000269|PubMed:7777858}.
uniprot
proteins