Nfatc3
entrez
361400
canonical
uniprot
A0A0G2JTY4
canonical
ensembl
ENSRNOG00000054264
resolver
ensembl
ENSRNOG00055018237
resolver
ensembl
ENSRNOG00060012555
resolver
ensembl
ENSRNOG00065012179
resolver
ensp
ENSRNOP00000069756
resolver
ensp
ENSRNOP00000090103
resolver
ensp
ENSRNOP00000102155
resolver
ensp
ENSRNOP00000104832
resolver
ensp
ENSRNOP00055024914
resolver
ensp
ENSRNOP00060016804
resolver
ensp
ENSRNOP00065015177
resolver
enst
ENSRNOT00000105048
resolver
enst
ENSRNOT00000168212
resolver
enst
ENSRNOT00055030929
resolver
enst
ENSRNOT00060021302
resolver
enst
ENSRNOT00065019804
resolver
genesymbol
Nfatc3
resolver
genesymbol_syn
Nfat4
resolver
uniprot
A0A8I6AB55
resolver
uniprot
A0ABK0LGV6
resolver
uniprot_entry
A0A8I6AB55_RAT
resolver
uniprot_entry
A0ABK0LGV6_RAT
resolver
uniprot_entry
NFAC3_RAT
resolver
amino_acid_sequence
MTTANCGAHDELDFKLVFGEDGAPTPVSQVSRPADLEPDDCASIYIFNVDPPPSTLNSSLGLPHHGLLQSHSSVLSPSFQLQGFKNYEGTDDISESKYSSLSGPKPFECPSIQITSISPNCHQETDAHEDDLHVNDPEREYLERPSRDHLYLPLEPSYRESSLSPSPASSVSSRSWFSDASSCESLSHIYDDVDSELNEAAARFTLGSPLTSPGGSPGGCPGEESWHQQYGPGHSLSPRQSPCHSPRSSITDENWLSPRPASGPSSRPTSPCGKRRHSSAEVCYAGSLSPHHSPVPSPGHSPRGSVTEDTWLTAPVHTGSGLSPAPFPFQYCVETDIPLKTRKTSDDQAAILPGKLEVCSDDQGSLSPSRETSVDDGLGSQYPLKKDSSGDQFLSVPSPFTWSKPKPGHTPIFRTSSLPPLDWPLPTHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYSEKPINLQMFIGTADDRYLRPHAFYQVHRITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVECSQRSAQELPHIEKYSINSCSVNGGHEMIVTGSNFLPESKIIFLEKGQDGRPHWEAEGKIIREKCQGGHIVLEVPPYHNPAVTSAVQVHFYLCNGKRKKSQSQRFTYTPVLMKQEQREDTDLSSVPSLPVPHSAQTQRPSSDTGHPHDSALSAPRSLICPVQPAYASMITSTHLPQLQCRDEGAGKEQHIIPSSVMHQPFQVTPTSPMGSSYQSIQTNMYNGPTCLPMNPASSQEFDPVLFQQDAALSNLVNLGCQPLSPIPFHSSNSDATGHLLAHSPHSVQTPPHLQSMGYHCSSAGQRSLSSPVAAQVTGQPSSHLQPITYCPSHPGSATAASPAASHALSSSPISGPPSPQLQSMPYQSPSSGTASSPSPVTRMHSGQHSTQAQSTGQGGLSVPSSLVCHSLCDPASFPPGGAAVSIKPEPEDQEPNFATIGLQDITLDDVNEIIGRDMSQITVSQGPEVIRDAPLPGPESPDVMSSNSAQ
uniprot
proteins
function
FUNCTION: Acts as a regulator of transcriptional activation. Binds to the TNFSF11/RANKL promoter region and promotes TNFSF11 transcription (By similarity). Binding to the TNFSF11 promoter region is increased by high levels of Ca(2+) which induce NFATC3 expression and may lead to regulation of TNFSF11 expression in osteoblasts (By similarity). Plays a role in promoting mesenteric arterial wall remodeling in response to the intermittent hypoxia-induced increase in EDN1 and ROCK signaling (By similarity). As a result NFATC3 colocalizes with F-actin filaments, translocates to the nucleus and promotes transcription of the smooth muscle hypertrophy and differentiation marker ACTA2 (By similarity). Promotes lipopolysaccharide-induced apoptosis and hypertrophy in cardiomyocytes (PubMed:30980393). Following JAK/STAT signaling activation and as part of a complex with NFATC4 and STAT3, binds to the alpha-beta E4 promoter region of CRYAB and activates transcription in cardiomyocytes (PubMed:19538478). In conjunction with NFATC4, involved in embryonic heart development via maintenance of cardiomyocyte survival, proliferation and differentiation (By similarity). Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (By similarity). Required for thymocyte maturation during DN3 to DN4 transition and during positive selection (By similarity). Positively regulates macrophage-derived polymicrobial clearance, via binding to the promoter region and promoting transcription of NOS2 resulting in subsequent generation of nitric oxide (By similarity). Involved in Ca(2+)-mediated transcriptional responses upon Ca(2+) influx via ORAI1 CRAC channels. {ECO:0000250|UniProtKB:P97305, ECO:0000250|UniProtKB:Q12968, ECO:0000269|PubMed:19538478, ECO:0000269|PubMed:30980393}.
uniprot
proteins
mass_dalton
115656
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by NFATC-kinase; dephosphorylated by calcineurin. {ECO:0000250|UniProtKB:Q12968}.; PTM: Ubiquitinated by STUB1/CHIP, leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q12968}.
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
19538478
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
30980393
uniprot
proteins
sequence_length
1076
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19538478, ECO:0000269|PubMed:30980393}. Nucleus {ECO:0000269|PubMed:19538478, ECO:0000269|PubMed:30980393}. Note=The subcellular localization of NFATC plays a key role in the regulation of gene transcription (By similarity). Rapid nuclear exit of NFATC is thought to be one mechanism by which cells distinguish between sustained and transient calcium signals (By similarity). Cytoplasmic when phosphorylated and nuclear after activation, that is controlled by calcineurin-mediated dephosphorylation (By similarity). Translocation to the nucleus is increased in the presence of calcium in pre-osteoblasts (By similarity). Translocates to the nucleus in the presence of EDN1 following colocalization with F-actin filaments, translocation is ROCK-dependent (PubMed:19538478). Translocates to the nucleus in response to lipopolysaccharide treatment of macrophages (By similarity). {ECO:0000250|UniProtKB:P97305, ECO:0000269|PubMed:19538478}.
uniprot
proteins