Helz
entrez
78455
canonical
uniprot
Q6DFV5
canonical
ensembl
ENSMUSG00000020721
resolver
ensp
ENSMUSP00000074533
resolver
ensp
ENSMUSP00000102357
resolver
ensp
ENSMUSP00000309857
resolver
ensp
ENSMUSP00000309858
resolver
ensp
ENSMUSP00000309861
resolver
genesymbol
Helz
resolver
genesymbol_syn
Kiaa0054
resolver
uniprot
A1L4L4
resolver
uniprot
A2AAU4
resolver
uniprot
Q8BZZ6
resolver
uniprot
Q8CHI3
resolver
uniprot
Q8VDI3
resolver
uniprot_entry
HELZ_MOUSE
resolver
uniprot_sec
A1L4L4
resolver
uniprot_sec
A2AAU4
resolver
uniprot_sec
Q8BZZ6
resolver
uniprot_sec
Q8CHI3
resolver
uniprot_sec
Q8VDI3
resolver
amino_acid_sequence
MEDRRAERSCEQACASLQRQDYDMALQHCTDALLSLGQYSMADFTGPCPVEVERIKIESLLYRIASFLQLKNYGQADEDCRHVLGEGLAKGERAFRAVLCCMQLKGKLQLVSSILAKSLSGESLNGMVTKDLTRLKTLLTETETATSNVLSGCHVEDLDEGSCNGWHFRPPPRGITSSEEYTLCKRFLEQGICRYGAQCTSAHSQEELAEWQKRYASRLIKLKQQSENKQLSGSYMETLIEKWMSSLSPEKVLSECIEGVQVEHSPDLSVTVNTKKSHQTWTFALTCKPARMLYRVALLYDAHRPHFSIIAISAGDSTTQVSQEVPENCQEWIGGKMAQNGLDHYVYKVGIAFNTEIFGTFRQTIVFDFGLEPVLMQRVMIDAASTEDLEYLMHAKRQLVTTAKRWDSSSKTIVDFEPNETTDLEKSLLIRYQIPLSADQLFTQSVLDKSLTKTNYQARLHDLLYIEEIAQYKEVSRFNLKVQLQILASFMLTGVSGGAKYAQNGQLFGRFKLTETLSEDTLAGRLVMTRVNAVYLLPVPKEKLVQSQGTKEKVYEATIEEKTKDYVFLRISRECCEELSLRPDCDIQVELQFQLNRLPLCEMHYALDRIKDNAVLFPDISMTPTIPWSPNRQWDEQLDPRLNAKQKEAVLAITTPLSIQLPPVLIIGPYGTGKTFTLAQAAKHILQQQETRILICTHSNSAADLYIKDYLHPYVEAGNPQARPLRVYFRNRWVKTVHPVVHQYCLISSTQSTFQMPQKEDILKHRVVVVTLSTSQYLCQLDLEPGFFTHVLLDEAAQAMECETIMPLALATKNTRIVLAGDHMQLSPFVYSEFARERNLHVSLLDRLYEHYPAEFPCRILLCENYRSHEAIINYTSELFYEGKLMASGKQPAHKDFYPLTFFTARGEDVQEKNSTAFYNNAEVFEVVERVEELRRKWPVAWGKLDDGSIGVVTPYADQVFRIRAELRKKRLSDVNVERVLNVQGKQFRVLFLSTVRTRHTCKHKQTPIKKKEQLLEDSTEDLDYGFLSNYKLLNTAITRAQSLVAVVGDPVALCSIGRCRKFWERFIALCHENHSLHGITFEQIKAQLEALELKKTYVLNPLAPEFIPRALRLQHSGNSSRQQQSPPKVKSLYHPQSDHFQSDGIVQPNPSVLIGNPIRAYTPPPPLGPHPNLGKSPSPVQRIDPHTGTSILYVPAVYGGNVVMSVPLPVPWTGYQGRFAVDPRIITHQAAMAYNMNLLHTHGRGSPIPYGLGHHPPVSLGQPQSQHAEKDQQEQNRNGKTDTNNPGPEINKIRTPEKKPTEPKQVDLESNPQNRSPESRPGVVYSNTKFPRKDHLNPRHINNLPLPAPHAQYAIPSRHFHPLPQLPRPPFPASQPHTLLNQQQNNLPEQPNQMAPQPNQVAPQPNQMTPQPNQVAPQPNQVVQQQSQAPPQAPQPAPQLSPAFQAGPTNAFFNNAVAHRPQSPAAEAVGPEQPPPPGLPDGHSPLRAITQPGPILASPLNNFVDESSPGLPIEEALDGVHGSVALETLRQQQARLQQWSEHHAYLSQGGIPYSHHHHPHLPHLPHTPIGLHQPPVRAEWKVAGRADDETETTFSRFQDLLRELSHRDQGDTGELAEMPPPQSRLLQYRQVQPRSPPAVPSPPSSTDHSSQFANFNDSSRDIEVANSPAFPQRLPPQLFGSPFSLPSEHLAPPPLKYLAPEGAWNFANLQQNHLIGPGFPYGLPPLPPRPPQNPFIHIQNHQHAAGQEPFHPLSSRTVSASSLPSLEEYEPRGPGRPLYQRRISSSSAQPCVEEASAPQDSLAQGKESQGHSNPPAFNFPAPESWANTTSSAPYQNIPCNGSSRTSQPRELIAPPKTVKPPEDQLKPESGEVSSSFNYSMLQHLGQFPPLMPNKQIAESANCSSQQSPAGSKPAMSYASALRAPPKPRPPPEQAKKGSDPLSLLQELSLGSSPGSNGFYSYFK
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: ATP-dependent RNA helicase that promotes degradation of mRNAs via its association with the CCR4-NOT deadenylase complex, leading to deadenylation, decapping, and subsequent degradation of target mRNAs. Can repress translation independently of mRNA decay in a manner dependent on both the CCR4-NOT complex and the helicase DDX6. Involved in promoting cell proliferation, translation initiation, and ribosomal protein S6 (RPS6) phosphorylation. {ECO:0000250|UniProtKB:P42694}.
uniprot
proteins
mass_dalton
219880
uniprot
proteins
protein_family
DNA2/NAM7 helicase family
uniprot
proteins
pubmed
12465718
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20305823
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21765940
uniprot
proteins
sequence_length
1964
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:21765940}.
uniprot
proteins