RAB44
entrez
401258
canonical
uniprot
Q7Z6P3
canonical
ensembl
ENSG00000255587
resolver
ensp
ENSP00000481054
resolver
enst
ENST00000612677
resolver
genesymbol
RAB44
resolver
hgnc
HGNC:21068
resolver
uniprot
A0A087WXI0
resolver
uniprot_entry
RAB44_HUMAN
resolver
uniprot_sec
A0A087WXI0
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000250|UniProtKB:P62820}.
uniprot
proteins
amino_acid_sequence
METGQRTSRKVRKLGSNRRRQTREPADGEGAAVAPEPESWSSQAAAELQAFFQDCGAKERGFVTREDLAVAKFSFLGSKEESEMIFDWVDVERKGHLSLEEFSSGLKNIFGSSQSPHRLRRRKPLPSKRVSATTSFPALEEADAEEKEAFLAFMEQLGTGHLLPKQMEIWQLWGQLRQEEPQLAGNLAGFLAKMTSRLQEAQADKEALELTLRKRDSDHHREVQQLYEEMEQQIRQEKQQLQAESDSRGLALTSQMQDVLEAKEREVQRLAEGQRELEAQLSHLRSTHQEAASENQQLQEAKRDLAGRLEEVRGQLQVTRGRLDAARGRVSWQVEEKLSFPGAGEKTPDPQAASPEEAPLPGLFGDNDDWDQLLSNFGSPPHGALQLCWSPPPTPRATSGPQTPRVVRQISISEPQAFLFGQEPSSDPDGAPRTPPGVTFSAKDNKGVDPHEQDIRAEQPVEPHDPDPNQEPGSTPEGRLLWGLSGSLVAPAFKVLIPLEDGPPPPANSPPPQAPAGSSKQIQASDPDDKGPGSWAPPSGAQPGAGAGPQEPTQTPPTMTERETQPGPSPTTALTGVGPAKPPRQRDALQQDLHATGSEPRLGTQRARALTLGPAEPFQGLEFVGPVPTERLEQGQAGPAVQEGLPEGLREAHGQVLGLGELSAFPHQELEEEPRSEEGKQEGRGGQDLSSEQSEQSVEAHGLETAHSELPQQDSLLVSLPSATPQAQVEAEGPTPGKSAPPRGSPPRGAQPGAGAGPQEPTQTPPTMAEQEAQPRPSLTTAHAEEQGPPHSREPRAESRLEDPGMDSREAGLTPSPGDPMAGGGPQANPDYLFHVIFLGDSNVGKTSFLHLLHQNSFATGLTATVGVDFRVKTLLVDNKCFVLQLWDTAGQERYHSMTRQLLRKADGVVLMYDITSQESFAHVRYWLDCLQDAGSDGVVILLLGNKMDCEEERQVSVEAGQQLAQELGVYFGECSAALGHNILEPVVNLARSLRMQEEGLKDSLVKVAPKRPPKRFGCCS
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Promotes mast cell degranulation upon IgE Fc receptor (FcERI)-mediated activation (PubMed:33641252). {ECO:0000250|UniProtKB:P62820, ECO:0000269|PubMed:33641252}.
uniprot
proteins
mass_dalton
110850
uniprot
proteins
mutagenesis
MUTAGEN 847; /note="T->N: Constitutively inactive (GDP-bound) mutant. Increased b-hexosaminidase secretion upon FcERI-mediated activation, similar to WT. No change in b-hexosaminidase secretion upon FcERI-mediated activation, compared to WT. No change in beta-hexosaminidase secretion upon ionomycin/PMA simulation, compared to WT."; /evidence="ECO:0000269|PubMed:33641252"; MUTAGEN 892; /note="Q->L: Constitutively active (GTP-bound) mutant. No change in beta-hexosaminidase secretion upon FcERI-mediated activation, compared to WT. Decreased beta-hexosaminidase secretion upon ionomycin/PMA simulation, compared to WT."; /evidence="ECO:0000269|PubMed:33641252
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
33641252
uniprot
proteins
sequence_length
1021
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Lysosome membrane {ECO:0000269|PubMed:33641252}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Localized mainly to lysosomes. {ECO:0000269|PubMed:33641252}.
uniprot
proteins