Ifi44l
entrez
15061
canonical
uniprot
Q9BDB7
canonical
ensembl
ENSMUSG00000039146
resolver
ensp
ENSMUSP00000044765
resolver
genesymbol
Ifi44l
resolver
genesymbol_syn
H28
resolver
uniprot
Q8SP46
resolver
uniprot_entry
IF44L_MOUSE
resolver
uniprot_sec
Q8SP46
resolver
amino_acid_sequence
MKVTARLTWIEEKILEKLLGNASLTLLYQSSAHKNCVSEMTQKYSLQGSTMTVFHLEKDVVVGVFILENFPRLVSEKPCTCAWFSLKRNNSSGISALFLNTKVIVDSEELIIFSLDGLSLSVTPLRGFTLALNDTVMNGLELNLGHGFLPVECEIFRVDGIKKNPSFIKKMVTAEQHRGKLLSALRAYKPYKDLVSEVRILLVGPVGSGKSSFFNSVKSAFQGHLTRQAIVGSDESSITKQYRVYSIKDGKSGETLPFMLCDSMGLEEGEEAGLCIDDIPHILQGCVPDRYQFNPCEPMKPKHSPHAASPPLKDRIHCVAFVLHINSVNTLSDKMVAKLKKIRKDVVDCGIGYVALLTNVEEYDEVLDDSFANMTETVTSLSQVQNVQKWLNIPIANILMVSNYASERRLEPMKDILVFAALRQMLRAADDALEDLPLEDTGNLAPF
uniprot
proteins
function
FUNCTION: Type I interferon-stimulated gene (ISG) that plays a critical role in antiviral and antibacterial activity. During bacterial infection, promotes macrophage differentiation and facilitates inflammatory cytokine secretion (By similarity). Plays a role in the control of respiratory syncycial virus/RSV infection, reducing the ability of the virus to replicate (PubMed:32611756). Acts as a feedback regulator of IFN responses by negatively regulating IKBKB kinase activity through interaction with FKBP5 (By similarity). {ECO:0000250|UniProtKB:Q53G44, ECO:0000269|PubMed:32611756}.; FUNCTION: Precursor of the histocompatibility antigen HA-28 in BALB.B mice. More generally, minor histocompatibility antigens refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD). More specifically, HA-28 minor antigen is transcribed in the BALB.B donor but not in host C57BL/6 cells. HA-28 is presented to the donor BALB.B cell surface by Kb MHC. This complex HA-28/Kb MHC elicits cytotoxic T-cell response in C57BL/6 mice immunized with BALB.B spleen cells. It induces C57BL/6 mice cells recognition and lysis by CD8 T-cell from BALB.B mice. {ECO:0000269|PubMed:11021531}.
uniprot
proteins
mass_dalton
49680
uniprot
proteins
protein_family
IFI44 family
uniprot
proteins
pubmed
11021531
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
32611756
uniprot
proteins
sequence_length
447
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11021531}.
uniprot
proteins