Fbxo7
entrez
69754
canonical
uniprot
Q3U7U3
canonical
ensembl
ENSMUSG00000001786
resolver
ensp
ENSMUSP00000113222
resolver
ensp
ENSMUSP00000113263
resolver
ensp
ENSMUSP00000120840
resolver
ensp
ENSMUSP00000306087
resolver
enst
ENSMUST00000117597
resolver
enst
ENSMUST00000120344
resolver
enst
ENSMUST00000130320
resolver
genesymbol
Fbxo7
resolver
uniprot
F7CT28
resolver
uniprot
F7CU20
resolver
uniprot
Q3UBC1
resolver
uniprot
Q3UD93
resolver
uniprot
Q3UGI9
resolver
uniprot
Q8K0A5
resolver
uniprot_entry
F7CT28_MOUSE
resolver
uniprot_entry
F7CU20_MOUSE
resolver
uniprot_entry
FBX7_MOUSE
resolver
uniprot_entry
Q3UD93_MOUSE
resolver
uniprot_entry
Q3UGI9_MOUSE
resolver
uniprot_sec
Q3UBC1
resolver
uniprot_sec
Q8K0A5
resolver
amino_acid_sequence
MKLRVRLQKRTQPLEVPESEPTLGQLRAHLSQVLLPTLGFSSDTRFAITLNNKDALTGDEETLASYGIVSGDLICLVLEDDMPAPNLPSSTDTEHSSLQDNDQPSLAATPSQTNIPDEQGTDSSQGQATPFDAWTDDSMEGPSQNVEAESIQDAMSMEEVSGFHPLEPMLCNETEDGQVPHSLETLYQSAGCSNISDALIVLVHLLMLESGYIPQGTETKAVTMPEKWKSSGVYKLQYTHPLCEGGFAVLTCVPLGNLIIINATIKVNGGIKNVKSVQLQPGSYVAAGVEPGESAAKVYKDLKKLSRLFKDQLVYPLLAFTRQVLNLPDVFGLVVLPLELKLRIFRLLDVHSVLALSAVCHDLLIASNDPLLWRCLYLRDFRDGTVRGPDTDWKELYRKKHIQRKEAQRMRHAMFLPSAHPIPFCPIPVYPRAYLPTSLLPPGIIGGEYDERPILPSVGDPVTSLIPRPGELPGQFRPLRPRFDPVDPLPGPHSLLPGRAIPNNRFPFRPGRGRSADSRLPFL
uniprot
proteins
function
FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Recognizes and ubiquitinates BIRC2 and the cell cycle regulator DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination. Mediates the ubiquitination and proteasomal degradation of UXT isoform 2, thereby impairing the NF-kappa-B signaling pathway. Inhibits NF-kappa-B pathway also by promoting the ubiquitination of TRAF2 (By similarity). Affects the assembly state and activity of the proteasome in the cells including neurons by ubiquitinating the proteasomal subunit PSMA2 via 'Lys-63'-linked polyubiquitin chains (PubMed:27497298). Promotes 'Lys-48'-linked polyubiquitination SIRT7, leading to the hydrogen peroxide-induced cell death (By similarity). {ECO:0000250|UniProtKB:Q9Y3I1}.
uniprot
proteins
mass_dalton
57649
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
27497298
uniprot
proteins
sequence_length
523
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Mitochondrion {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Predominantly cytoplasmic. A minor proportion is detected in the nucleus. Relocates from the cytosol to depolarized mitochondria (By similarity). {ECO:0000250}.
uniprot
proteins