ACSS1
entrez
84532
canonical
uniprot
Q9NUB1
canonical
ensembl
ENSG00000154930
resolver
ensp
ENSP00000316924
resolver
ensp
ENSP00000388793
resolver
ensp
ENSP00000439304
resolver
ensp
ENSP00000557223
resolver
ensp
ENSP00000557224
resolver
ensp
ENSP00000668939
resolver
genesymbol
ACSS1
resolver
genesymbol_syn
ACAS2L
resolver
genesymbol_syn
KIAA1846
resolver
hgnc
HGNC:16091
resolver
uniprot
B3KXL2
resolver
uniprot
B4DJZ3
resolver
uniprot
D3DW48
resolver
uniprot
F5H6F4
resolver
uniprot
F8W7Y1
resolver
uniprot
Q1RMZ4
resolver
uniprot
Q5TF42
resolver
uniprot
Q8IV99
resolver
uniprot
Q8N234
resolver
uniprot
Q96JI1
resolver
uniprot
Q96JX6
resolver
uniprot
Q9NU28
resolver
uniprot_entry
ACS2L_HUMAN
resolver
uniprot_entry
Q1RMZ4_HUMAN
resolver
uniprot_sec
B3KXL2
resolver
uniprot_sec
B4DJZ3
resolver
uniprot_sec
D3DW48
resolver
uniprot_sec
F5H6F4
resolver
uniprot_sec
F8W7Y1
resolver
uniprot_sec
Q5TF42
resolver
uniprot_sec
Q8IV99
resolver
uniprot_sec
Q8N234
resolver
uniprot_sec
Q96JI1
resolver
uniprot_sec
Q96JX6
resolver
uniprot_sec
Q9NU28
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by acetylation at Lys-642 and activated by deacetylation mediated by the deacetylase SIRT3. {ECO:0000269|PubMed:16788062}.
uniprot
proteins
amino_acid_sequence
MAARTLGRGVGRLLGSLRGLSGQPARPPCGVSAPRRAASGPSGSAPAVAAAAAQPGSYPALSAQAAREPAAFWGPLARDTLVWDTPYHTVWDCDFSTGKIGWFLGGQLNVSVNCLDQHVRKSPESVALIWERDEPGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVAAMLACARIGAVHTVIFAGFSAESLAGRINDAKCKVVITFNQGLRGGRVVELKKIVDEAVKHCPTVQHVLVAHRTDNKVHMGDLDVPLEQEMAKEDPVCAPESMGSEDMLFMLYTSGSTGMPKGIVHTQAGYLLYAALTHKLVFDHQPGDIFGCVADIGWITGHSYVVYGPLCNGATSVLFESTPVYPNAGRYWETVERLKINQFYGAPTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPINCEAWEWLHRVVGDSRCTLVDTWWQTETGGICIAPRPSEEGAEILPAMAMRPFFGIVPVLMDEKGSVVEGSNVSGALCISQAWPGMARTIYGDHQRFVDAYFKAYPGYYFTGDGAYRTEGGYYQITGRMDDVINISGHRLGTAEIEDAIADHPAVPESAVIGYPHDIKGEAAFAFIVVKDSAGDSDVVVQELKSMVATKIAKYAVPDEILVVKRLPKTRSGKVMRRLLRKIITSEAQELGDTTTLEDPSIIAEILSVYQKCKDKQAAAK
uniprot
proteins
ec_number
6.2.1.1
uniprot
proteins
ec_number
6.2.1.17
uniprot
proteins
function
FUNCTION: Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:16788062). Acetate is the preferred substrate (PubMed:16788062). Can also utilize propionate with a much lower affinity (By similarity). Provides acetyl-CoA that is utilized mainly for oxidation under ketogenic conditions (By similarity). Involved in thermogenesis under ketogenic conditions, using acetate as a vital fuel when carbohydrate availability is insufficient (By similarity). {ECO:0000250|UniProtKB:Q99NB1, ECO:0000269|PubMed:16788062}.
uniprot
proteins
mass_dalton
74857
uniprot
proteins
mutagenesis
MUTAGEN 642; /note="K->Q: Loss of activity."; /evidence="ECO:0000269|PubMed:16788062
uniprot
proteins
post_translational_modification
PTM: Reversibly acetylated on Lys-642 (PubMed:16788062). The acetyl-CoA synthase activity is inhibited by acetylation and activated by deacetylation mediated by the deacetylase SIRT3. {ECO:0000269|PubMed:16788062}.
uniprot
proteins
protein_family
ATP-dependent AMP-binding enzyme family
uniprot
proteins
pubmed
11347906
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16788062
uniprot
proteins
pubmed
19535340
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
689
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:16788062}.
uniprot
proteins