Leprot
entrez
56766
canonical
uniprot
Q9JLS8
canonical
ensembl
ENSRNOG00055007154
resolver
ensembl
ENSRNOG00060019999
resolver
ensembl
ENSRNOG00065018145
resolver
ensp
ENSRNOP00055009359
resolver
ensp
ENSRNOP00060028472
resolver
ensp
ENSRNOP00065024199
resolver
enst
ENSRNOT00055011848
resolver
enst
ENSRNOT00060034673
resolver
enst
ENSRNOT00065030423
resolver
genesymbol
Leprot
resolver
genesymbol_syn
Lepr
resolver
genesymbol_syn
Obr
resolver
uniprot_entry
OBRG_RAT
resolver
amino_acid_sequence
MAGVKALVALSFSGAIGLTFLMLGCALEDYGVYWPLFVLIFYVISPIPYFIAKRVTYDSDATSSACRELAYFFTTGIVVSAFGFPVILARVAVIKWGACGLVLAGNAVIFLTIQGFFLVFGRGDDFSWEQW
uniprot
proteins
function
FUNCTION: Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin (By similarity). Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability. {ECO:0000250, ECO:0000269|PubMed:19907080}.
uniprot
proteins
mass_dalton
14320
uniprot
proteins
protein_family
OB-RGRP/VPS55 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19907080
uniprot
proteins
pubmed
23772379
uniprot
proteins
sequence_length
131
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..27; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 32..52; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 69..89; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 100..120; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins