Parp12
entrez
243771
canonical
uniprot
Q8BZ20
canonical
ensembl
ENSMUSG00000038507
resolver
ensp
ENSMUSP00000039704
resolver
enst
ENSMUST00000038398
resolver
genesymbol
Parp12
resolver
genesymbol_syn
Zc3hdc1
resolver
uniprot
Q0VB94
resolver
uniprot
Q80VL6
resolver
uniprot
Q8K333
resolver
uniprot
Q8R3U2
resolver
uniprot_entry
PAR12_MOUSE
resolver
uniprot_sec
Q0VB94
resolver
uniprot_sec
Q80VL6
resolver
uniprot_sec
Q8K333
resolver
uniprot_sec
Q8R3U2
resolver
amino_acid_sequence
MAQAAVAVAEVTQLLCAAGGALELAELRRRLRTSLGTDALERLLRDCGRFVVASRAVVAVGAGREAAAAASERLVLAVSSLRLCRAHQGPKPGCTGLCAQLHLCKFLIYGNCKFLKTGKNCRNGHNLKTDHNLSVLRTHGVDHLTYTELCQLLLQNDPSLLPDICLHYNKGDGPFGSCSFQKQCIKLHICQYFLQGECKFGTSCKRSHEFTNSESLEQLERLGLSSDLVSRLLSTYRNAYDIKNKGSALSKVSPSPAGPQGSSERKDSSGPVSPGTPSQEESEQICLYHIRKSCSFQEKCHRVHFHLPYRWQFLDGGKWKDLDNMELIEEAYSNPSKDRIVYTESAAGFHFDNLDFNSMKFGNTLARRLSTASSVTKPPHFILTTDWIWYWMDEFGSWQEYGRQGSGHPVTTISSSDVERAYLAFCAPGADAQAATLKFQAGKHNYELHFKAFLQKNLVYGTIRKVCRRPKYVSPQDVQMKQSCNTKLHGPKSIPDYWDPAALPDLGFKKITLSSSSEEYQKVWNIFNRTLPFYFVQKIERIQNMGLWEVYQWQKCQMQKQNGGKEVDERQLFHGTSANFVDAICQQNFDWRVCGLHGTSYGKGSYFARDAAYSHHYSKSDTHSHMMFLARVLVGDFVRGSTSFVRPPAKEGQSNAFYDSCVNSMSDPTIFVVFEKHQVYPEYLIQYSTSSKPPASPSIFVALGNLFTSRQ
uniprot
proteins
ec_number
2.4.2.-
uniprot
proteins
function
FUNCTION: Mono-ADP-ribosyltransferase that mediates mono-ADP-ribosylation of target proteins. Displays anti-alphavirus activity during IFN-gamma immune activation by directly ADP-ribosylating the alphaviral non-structural proteins nsP3 and nsP4. Acts as a component of the PRKD1-driven regulatory cascade that selectively controls a major branch of the basolateral transport pathway by catalyzing the MARylation of GOLGA1. Acts also as a key regulator of mitochondrial function, protein translation, and inflammation (PubMed:35916471). Inhibits PINK1/Parkin-dependent mitophagy and promotes cartilage degeneration by inhibiting the ubiquitination and SUMOylation of MFN1/2 by up-regulating ISG15 and ISGylation. {ECO:0000250|UniProtKB:Q9H0J9, ECO:0000269|PubMed:35916471}.
uniprot
proteins
mass_dalton
79917
uniprot
proteins
post_translational_modification
PTM: Auto-mono-ADP-ribosylated. {ECO:0000250|UniProtKB:Q9H0J9}.; PTM: Phosphorylated by PRKD1. {ECO:0000250|UniProtKB:Q9H0J9}.
uniprot
proteins
protein_family
ARTD/PARP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
35916471
uniprot
proteins
sequence_length
711
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H0J9}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q9H0J9}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:Q9H0J9}. Note=Translocates from the Golgi complex to stress granules upon stress conditions. {ECO:0000250|UniProtKB:Q9H0J9}.
uniprot
proteins