SLC26A9
entrez
115019
canonical
uniprot
Q7LBE3
canonical
ensembl
ENSG00000174502
resolver
ensp
ENSP00000356102
resolver
ensp
ENSP00000356103
resolver
genesymbol
SLC26A9
resolver
hgnc
HGNC:14469
resolver
uniprot
A7E2V6
resolver
uniprot
B1AVM8
resolver
uniprot
B1AVM9
resolver
uniprot
B3KXK1
resolver
uniprot
B7ZKK2
resolver
uniprot
Q96PK9
resolver
uniprot
Q96RN0
resolver
uniprot_entry
B3KXK1_HUMAN
resolver
uniprot_entry
S26A9_HUMAN
resolver
uniprot_sec
A7E2V6
resolver
uniprot_sec
B1AVM8
resolver
uniprot_sec
B1AVM9
resolver
uniprot_sec
B7ZKK2
resolver
uniprot_sec
Q96PK9
resolver
uniprot_sec
Q96RN0
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by ammonium and thiosulfate. {ECO:0000269|PubMed:11834742, ECO:0000269|PubMed:15800055}.
uniprot
proteins
amino_acid_sequence
MSQPRPRYVVDRAAYSLTLFDDEFEKKDRTYPVGEKLRNAFRCSSAKIKAVVFGLLPVLSWLPKYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGVHQMVPGTFAVISILVGNICLQLAPESKFQVFNNATNESYVDTAAMEAERLHVSATLACLTAIIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFTFIDICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGGCKMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHGYDVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITMLVLGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPYGVAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYFANSEIFRQKVIAKTGMDPQKVLLAKQKYLKKQEKRRMRPTQQRRSLFMKTKTVSLQELQQDFENAPPTDPNNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPPFVTFHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGSLECKHVFPSIHDAVLFAQANARDVTPGHNFQGAPGDAELSLYDSEEDIRSYWDLEQEMFGSMFHAETLTAL
uniprot
proteins
function
FUNCTION: Ion transporter that can act both as an ion channel and anion exchanger (PubMed:15800055, PubMed:17673510, PubMed:26801567, PubMed:32818062). Mainly acts as a chloride channel, which mediate uncoupled chloride anion transport in an alternate-access mechanism where a saturable binding site is alternately exposed to either one or the other side of the membrane (PubMed:17673510, PubMed:26801567, PubMed:32818062). Also acts as a DIDS- and thiosulfate- sensitive anion exchanger the exchange of chloride for bicarbonate ions across the cell membrane (PubMed:11834742, PubMed:15800055). {ECO:0000269|PubMed:11834742, ECO:0000269|PubMed:15800055, ECO:0000269|PubMed:17673510, ECO:0000269|PubMed:26801567, ECO:0000269|PubMed:32818062}.
uniprot
proteins
mass_dalton
86988
uniprot
proteins
mutagenesis
MUTAGEN 88; /note="Q->A: Reduced chloride ion flux."; /evidence="ECO:0000269|PubMed:32818062"; MUTAGEN 131; /note="I->A: Reduced chloride ion flux."; /evidence="ECO:0000269|PubMed:32818062"; MUTAGEN 132; /note="S->A: Reduced chloride ion flux."; /evidence="ECO:0000269|PubMed:32818062"; MUTAGEN 166; /note="E->A: Reduced chloride ion flux."; /evidence="ECO:0000269|PubMed:32818062"; MUTAGEN 201; /note="E->K: Increased current; when associated with A-781."; /evidence="ECO:0000269|PubMed:32818062"; MUTAGEN 775..782; /note="EQEMFGSM->AAAGGG: Increased current."; /evidence="ECO:0000269|PubMed:32818062"; MUTAGEN 775..776; /note="EQ->AA: Increased current."; /evidence="ECO:0000269|PubMed:32818062"; MUTAGEN 781; /note="S->A: Increased current; when associated with K-201."; /evidence="ECO:0000269|PubMed:32818062"; MUTAGEN 783; /note="F->G: Increased current."; /evidence="ECO:0000269|PubMed:32818062
uniprot
proteins
protein_family
SLC26A/SulP transporter (TC 2.A.53) family
uniprot
proteins
pubmed
11834742
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15800055
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17673510
uniprot
proteins
pubmed
22544634
uniprot
proteins
pubmed
26801567
uniprot
proteins
pubmed
32818062
uniprot
proteins
sequence_length
791
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17673510, ECO:0000269|PubMed:26801567}; Multi-pass membrane protein {ECO:0000269|PubMed:32818062}. Endomembrane system {ECO:0000269|PubMed:26801567}; Multi-pass membrane protein {ECO:0000269|PubMed:32818062}. Note=Localization to the cell membrane is inhibited by WNK kinases (WNK1, WNK2, WNK3 or WNK4) in a kinase-independent mechanism. {ECO:0000269|PubMed:17673510}.
uniprot
proteins
transmembrane_region
TRANSMEM 71..96; /note="Helical"; /evidence="ECO:0000269|PubMed:32818062, ECO:0007744|PDB:7CH1"; TRANSMEM 100..117; /note="Helical"; /evidence="ECO:0000269|PubMed:32818062, ECO:0007744|PDB:7CH1"; TRANSMEM 129..142; /note="Helical"; /evidence="ECO:0000269|PubMed:32818062, ECO:0007744|PDB:7CH1"; TRANSMEM 172..190; /note="Helical"; /evidence="ECO:0000269|PubMed:32818062, ECO:0007744|PDB:7CH1"; TRANSMEM 203..224; /note="Helical"; /evidence="ECO:0000269|PubMed:32818062, ECO:0007744|PDB:7CH1"; TRANSMEM 255..273; /note="Helical"; /evidence="ECO:0000269|PubMed:32818062, ECO:0007744|PDB:7CH1"; TRANSMEM 282..297; /note="Helical"; /evidence="ECO:0000269|PubMed:32818062, ECO:0007744|PDB:7CH1"; TRANSMEM 328..348; /note="Helical"; /evidence="ECO:0000269|PubMed:32818062, ECO:0007744|PDB:7CH1"; TRANSMEM 367..382; /note="Helical"; /evidence="ECO:0000269|PubMed:32818062, ECO:0007744|PDB:7CH1"; TRANSMEM 391..400; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q8BU91"; TRANSMEM 405..423; /note="Helical"; /evidence="ECO:0000269|PubMed:32818062, ECO:0007744|PDB:7CH1"; TRANSMEM 429..450; /note="Helical"; /evidence="ECO:0000269|PubMed:32818062, ECO:0007744|PDB:7CH1"; TRANSMEM 465..476; /note="Helical"; /evidence="ECO:0000269|PubMed:32818062, ECO:0007744|PDB:7CH1"; TRANSMEM 478..489; /note="Helical"; /evidence="ECO:0000269|PubMed:32818062, ECO:0007744|PDB:7CH1
uniprot
proteins