Mettl1
entrez
17299
canonical
uniprot
Q9Z120
canonical
ensembl
ENSMUSG00000006732
resolver
ensp
ENSMUSP00000006915
resolver
ensp
ENSMUSP00000113030
resolver
enst
ENSMUST00000006915
resolver
genesymbol
Mettl1
resolver
uniprot
Q3TU83
resolver
uniprot
Q921G5
resolver
uniprot_entry
TRMB_MOUSE
resolver
uniprot_sec
Q3TU83
resolver
uniprot_sec
Q921G5
resolver
amino_acid_sequence
MMAGAEAPQPQKRYYRQRAHSNPMADHTLRYPVKPEEMDWSELYPEFFAPLIQNKSHDDPKDEKEKHSGAQVEFADIGCGYGGLLVALSPLFPDTLILGLEIRVKVSDYVQDRIRALRAAPGGGFQNIACLRSNAMKHLPNFFRKGQLAKMFFLFPDPHFKRTKHKWRIISPTLLAEYAYVLRVGGLVYTVTDVPELHEWMCTHFEEHPLFERVPLEELSEDPIVEHLGSSTEEGKKVLRNGGKNFPAVFRRIQDPLLQAVTPNPTLP
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
ec_number
2.1.1.33
uniprot
proteins
function
FUNCTION: Catalytic component of METTL1-WDR4 methyltransferase complex that mediates the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs) (By similarity). Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in a large subset of tRNAs that contain the 5'-RAGGU-3' motif within the variable loop (By similarity). M7G46 interacts with C13-G22 in the D-loop to stabilize tRNA tertiary structure and protect tRNAs from decay (By similarity). Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs (PubMed:29983320). Internal N(7)-methylguanine methylation of mRNAs in response to stress promotes their relocalization to stress granules, thereby suppressing their translation (PubMed:29983320). Also methylates a specific subset of miRNAs, such as let-7 (By similarity). N(7)-methylguanine methylation of let-7 miRNA promotes let-7 miRNA processing by disrupting an inhibitory secondary structure within the primary miRNA transcript (pri-miRNA) (By similarity). Acts as a regulator of embryonic stem cell self-renewal and differentiation (PubMed:29983320). {ECO:0000255|HAMAP-Rule:MF_03055, ECO:0000269|PubMed:29983320}.
uniprot
proteins
mass_dalton
30603
uniprot
proteins
pathway_participation
PATHWAY: tRNA modification; N(7)-methylguanine-tRNA biosynthesis. {ECO:0000269|PubMed:29983320}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-21 by PKB/AKT1 inactivates its methyltransferase activity via a steric interference mechanism in the active site that locally disrupts the catalytic center (By similarity). Phosphorylation at Ser-21 does not affect the interaction with WDR4 (By similarity). {ECO:0000255|HAMAP-Rule:MF_03055}.
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
TrmB family
uniprot
proteins
pubmed
10329009
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29983320
uniprot
proteins
pubmed
34352206
uniprot
proteins
sequence_length
268
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|HAMAP-Rule:MF_03055}.
uniprot
proteins