Eif2s3y
entrez
26908
canonical
uniprot
Q9Z0N2
canonical
ensembl
ENSMUSG00000069049
resolver
ensp
ENSMUSP00000088736
resolver
ensp
ENSMUSP00000189016
resolver
enst
ENSMUST00000091197
resolver
genesymbol
Eif2s3y
resolver
uniprot_entry
IF2H_MOUSE
resolver
amino_acid_sequence
MAGGEAGVTLGQPHLSRQDLATLDVTKLTPLSREIISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDSSCPRPECYRSCGSSTPDEFPSDIPGTKGNFRLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPLRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDGEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIGWGQIRRGVTIKPTIDDE
uniprot
proteins
ec_number
3.6.5.3
uniprot
proteins
function
FUNCTION: Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). Along with its paralog on chromosome X, may contribute to spermatogenesis up to the round spermatid stage (PubMed:11528390, PubMed:25579647, PubMed:26823431). {ECO:0000250|UniProtKB:P05198, ECO:0000269|PubMed:11528390, ECO:0000269|PubMed:25579647, ECO:0000269|PubMed:26823431}.
uniprot
proteins
mass_dalton
51131
uniprot
proteins
protein_family
Classic translation factor GTPase family
uniprot
proteins
protein_family
EIF2G subfamily
uniprot
proteins
protein_family
TRAFAC class translation factor GTPase superfamily
uniprot
proteins
pubmed
11528390
uniprot
proteins
pubmed
12023983
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16325480
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25579647
uniprot
proteins
pubmed
26823431
uniprot
proteins
pubmed
9736774
uniprot
proteins
sequence_length
472
uniprot
proteins