Otol1
entrez
229389
canonical
uniprot
Q4ZJM7
canonical
ensembl
ENSMUSG00000027788
resolver
ensp
ENSMUSP00000057607
resolver
enst
ENSMUST00000053013
resolver
genesymbol
Otol1
resolver
genesymbol_syn
Gm414
resolver
uniprot
B9EKG7
resolver
uniprot
Q3TYP6
resolver
uniprot_entry
OTOL1_MOUSE
resolver
uniprot_sec
B9EKG7
resolver
uniprot_sec
Q3TYP6
resolver
amino_acid_sequence
MWIFSSLCAVLTILAMDDVATEAKTTPYTKFTKKSEGKEMLKGLKPSSGFFLDGEETVHTETAAMAEPTTGSPALAMAESTAGPSASATTRLLPFESFSLDTTGFVLNCCHCCSFVTGQKGEPGKMGKQGPKGETGDTGSPGHPGTTGPQGPKGQKGEKGLKGDRGDQGAGGIPGYPGKPGEQGALGPKGDKGTIGPAGTKGQKGSKGELCGNGTKGEKGDPGASGAHGFIGEPGAKGEKGGVGEKGYRGDLGERGEKGQKGEKGMEGEKGSRGDVGSEGKRGSDGLPGLRGDSGPKGEKGEIGSPGFTGPAGPKGELGSKGVRGPTGKKGSRGVKGSKGEATQVPQSAFSALLSKPFPPPNVPIKFDKILSNDQGDYSPVTGKFNCSVPGTYIFSYHVTVRGRPARISLVARNRKQFKSRETLYGQQVDQASLLLILKLSAGDQVWLEVSKDWNGLYVGPEDDSIFSGFLLYPEETFSKSP
uniprot
proteins
function
FUNCTION: Collagen-like protein specifically expressed in the inner ear, which provides an organic scaffold for otoconia, a calcium carbonate structure in the saccule and utricle of the ear (PubMed:21655225, PubMed:24748133, PubMed:29076638). Acts as a scaffold for biomineralization: sequesters calcium and forms interconnecting fibrils between otoconia that are incorporated into the calcium crystal structure (PubMed:21655225, PubMed:24748133, PubMed:29076638). Together with OC90, modulates calcite crystal morphology and growth kinetics (PubMed:24748133). {ECO:0000269|PubMed:21655225, ECO:0000269|PubMed:24748133, ECO:0000269|PubMed:29076638}.
uniprot
proteins
mass_dalton
49601
uniprot
proteins
post_translational_modification
PTM: Not N-glycosylated. {ECO:0000269|PubMed:20856818}.
uniprot
proteins
protein_family
OTOL1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17300776
uniprot
proteins
pubmed
20856818
uniprot
proteins
pubmed
21655225
uniprot
proteins
pubmed
22841569
uniprot
proteins
pubmed
24748133
uniprot
proteins
pubmed
29076638
uniprot
proteins
sequence_length
482
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:20856818}. Note=Localized in both the surrounding otoconial matrix and otoconia. {ECO:0000269|PubMed:20856818}.
uniprot
proteins