Cemip2
entrez
83921
canonical
uniprot
Q5FWI3
canonical
ensembl
ENSMUSG00000024754
resolver
ensp
ENSMUSP00000025663
resolver
ensp
ENSMUSP00000093908
resolver
enst
ENSMUST00000025663
resolver
enst
ENSMUST00000096194
resolver
genesymbol
Cemip2
resolver
genesymbol_syn
Kiaa1412
resolver
genesymbol_syn
Tmem2
resolver
uniprot
Q3UE15
resolver
uniprot
Q3UE98
resolver
uniprot
Q6DFZ0
resolver
uniprot
Q6ZPR7
resolver
uniprot
Q8BS93
resolver
uniprot
Q8VE53
resolver
uniprot
Q9QY22
resolver
uniprot_entry
CEIP2_MOUSE
resolver
uniprot_entry
Q8BS93_MOUSE
resolver
uniprot_sec
Q3UE15
resolver
uniprot_sec
Q3UE98
resolver
uniprot_sec
Q6DFZ0
resolver
uniprot_sec
Q6ZPR7
resolver
uniprot_sec
Q8VE53
resolver
uniprot_sec
Q9QY22
resolver
amino_acid_sequence
MYAAGSRGHSPAFLQPQNGNGHRSPGYVPGKVVPLRPAPPPKNHASAKLTSRSQDAPATFAFSPEEQRTPSESRKRKRHKNTFICFAITSFSFFVALAVILGISSKYAPDENCPDQNPRLRNWDPGQDSAKHIVIKEGDLFRLTSDATVDSIVIQDGGLLVFGDDKDGSKNITLRTRYILIQDGGALHIGAEKCRYRSKATITLYGKSDERESMPIFGKKFIGVEAGGTLELHGAQRTSWTMLARTLHSSGLPFGSYAFEKDFSRGLNVRVIDQDTARVLENEKFDTHEYHNESRRLQEFLRAQEPGRIVAIAVGDSAVKSLLQGTIQMIQDRLGSKLIQGLGYRQAWALVGVIDGGSSSCNESVRNYENHSTGGKALAQGEFYTLDGQKFSVTAYSEWSQGISLSGFRVDIADGVKLHLLDDVSTWEAGDRIVVASTDYSMYQAEELTLLRCPECSRSQVKVKEIPQYLHVGEIIDGIDMRAEVGLLTRNIVIQGEMEDSCYAENHCQFFDYDTFGGHVMIEKNFTSVHLSYVELKHMGQQHMGRYPVHFHLCGDVDSKGGYSQPASVDGLSVHHSFSRCITVHGTSGLLIKDTIGFDTLGHCFFLEDGVEQRNILYHNLGLLTKPGTLLPTDRNSSMCTVMRDGVFGNYVPVPTTDCMAVSTFWIAHPNNHLINNAAAGSQDAGIWYLFHKEPTGESSGLQLLEKPELTPLGIFYNNRVHSNFKAGLFVDKGVKTTNASASDPREYLCLDNSARFRPHQDADPEKPRVAAIIDRLIAFKNNDNGAWVRGGDIIVQNSAFADNGKGLTFASDGSFPSDEGSSQEVTESLFVGESRNYGFQGGQNKYMGTGGIDQKPRTLPRNRTFPIRGFQIYDGPIHLTKSTFKKYVPTPDRYSSAIGFLMKNSWQTTPRNNVSLVKFGPQVSLNVFFGKPGPWFEDCELDGDKNSIFHDIDGSVTGYKDTYVGRMDNYLIRHPNCVNVTKWNAVICSGTYAQVYVQTWNTPNLSMIITRDEYPSHPMVLRGINQRAISPQYQPVVMLEKGYTIHWNGPAPRTTFLYLVNFNKDDWIRVGLCYPANTSFQVTVGFLQRQNGSLSRIEDYEPARSMEELQKKPSERKFYFDSGTGLLFLYLRAHSHRDGHSYCSSQGCERVKIQAATDSKDISNCMAKAYPQYYKKPSAVKRMPAMLTGLCQGCGTHQMVFTSDPHKSYLPVRFQSPGKAEIQRGDPSIISVNGTDFTFRSAGALLLIVDACSVPFRVKEKRMFLSADVSHMEEYFKASIPPRSIVLLSTRGEIKQLNISDSLAVLGLAKPAHLYSKGSVVFLGFSGNFAPSWTKLFTSPDEQGLGVLEQFLPLQMEEYGCSRTGSVHRRDLDLLQQALKVL
uniprot
proteins
ec_number
3.2.1.35
uniprot
proteins
function
FUNCTION: Cell surface hyaluronidase that mediates the initial cleavage of extracellular high-molecular-weight hyaluronan into intermediate-size hyaluronan of approximately 5 kDa fragments (PubMed:28246172, PubMed:37196767, PubMed:37527776). Very specific to hyaluronan; not able to cleave chondroitin sulfate or dermatan sulfate (PubMed:28246172). Has an essential function in systemic hyaluronan catabolism and turnover and regulates cell adhesion and migration via hyaluronan degradation at focal adhesion sites (PubMed:33647313, PubMed:34624311). Acts as a regulator of angiogenesis and heart morphogenesis by mediating degradation of extracellular hyaluronan, thereby regulating VEGF signaling (By similarity). {ECO:0000250|UniProtKB:A3KPQ7, ECO:0000269|PubMed:28246172, ECO:0000269|PubMed:33647313, ECO:0000269|PubMed:34624311, ECO:0000269|PubMed:37196767, ECO:0000269|PubMed:37527776}.
uniprot
proteins
mass_dalton
153801
uniprot
proteins
mutagenesis
MUTAGEN 248; /note="H->N: Slight suppression of hyaluronidase activity. Hyaluronidase activity is abolished; when associated with 303-F."; /evidence="ECO:0000269|PubMed:37196767"; MUTAGEN 260..262; /note="EKD->NKQ: Does not affect hyaluronidase activity."; /evidence="ECO:0000269|PubMed:28246172"; MUTAGEN 265; /note="R->A,C: Strongly decreased hyaluronidase activity."; /evidence="ECO:0000269|PubMed:28246172"; MUTAGEN 273; /note="D->N: Strongly decreased hyaluronidase activity."; /evidence="ECO:0000269|PubMed:28246172"; MUTAGEN 275; /note="D->N: Does not affect hyaluronidase activity."; /evidence="ECO:0000269|PubMed:28246172"; MUTAGEN 279; /note="V->I: Slightly increases of hyaluronidase activity."; /evidence="ECO:0000269|PubMed:37196767"; MUTAGEN 281..283; /note="ENE->QNQ: Does not affect hyaluronidase activity."; /evidence="ECO:0000269|PubMed:28246172"; MUTAGEN 286; /note="D->N: Strongly decreased hyaluronidase activity."; /evidence="ECO:0000269|PubMed:28246172"; MUTAGEN 303; /note="A->F: Slight suppression of hyaluronidase activity. Hyaluronidase activity is abolished; when associated with 248-N."; /evidence="ECO:0000269|PubMed:37196767"; MUTAGEN 337; /note="K->E: Does not affect hyaluronidase activity."; /evidence="ECO:0000269|PubMed:37196767"; MUTAGEN 359; /note="S->T: Does not affect hyaluronidase activity."; /evidence="ECO:0000269|PubMed:37196767
uniprot
proteins
protein_family
CEMIP family
uniprot
proteins
pubmed
10767548
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21896629
uniprot
proteins
pubmed
28246172
uniprot
proteins
pubmed
33647313
uniprot
proteins
pubmed
34624311
uniprot
proteins
pubmed
37196767
uniprot
proteins
pubmed
37527776
uniprot
proteins
sequence_length
1383
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28246172}; Single-pass type II membrane protein {ECO:0000269|PubMed:28246172}.
uniprot
proteins
transmembrane_region
TRANSMEM 83..103; /note="Helical; Signal-anchor for type II membrane protein
uniprot
proteins