Ext2
entrez
14043
canonical
uniprot
P70428
canonical
ensembl
ENSMUSG00000027198
resolver
ensp
ENSMUSP00000028623
resolver
ensp
ENSMUSP00000176368
resolver
ensp
ENSMUSP00000176374
resolver
ensp
ENSMUSP00000176378
resolver
ensp
ENSMUSP00000176381
resolver
enst
ENSMUST00000028623
resolver
genesymbol
Ext2
resolver
uniprot
P70395
resolver
uniprot
Q3TPI7
resolver
uniprot
Q3UDB5
resolver
uniprot
Q923D6
resolver
uniprot_entry
EXT2_MOUSE
resolver
uniprot_entry
Q3UDB5_MOUSE
resolver
uniprot_sec
P70395
resolver
uniprot_sec
Q3TPI7
resolver
uniprot_sec
Q923D6
resolver
amino_acid_sequence
MCASVKSNIRGPALIPRMKTKHRIYYVTLFSIVLLGLIATGMFQFWPHSIESSSDGGVEKRSIREVPVVRLPTDSPIPERGDLSCRMHTCFDVYRCGFNPKNKIKVYIYPLKKYVDDAGVPVSSAISREYNELLTAISDSDYYTDDINRACLFVPSIDVLNQNPLRIKETAQALAQLSRWDRGTNHLLFNMLPGAPPDYNTALDVPRDRALLAGGGFSTWTYRQGYDVSIPVFSPLSAEMALPEKAPGPRRYFLLSSQMAIHPEYREELEALQAKHQESVLVLDKCTNLSEGVLSVRKRCHQHQVFDYPQVLQEATFCTVLRGARLGQAVLSDVLQAGCVPVVIADSYILPFSEVLDWKRASVVVPEEKMSDVYSILQNIPQRQIEEMQRQARWFWEAYFQSIKAIALATLQIINDRIYPYAAISYEEWNDPPAVKWASVSNPLFLPLIPPQSQGFTAIVLTYDRVESLFRVITEVSKVPSLSKLLVVWNNQNKNPPEESLWPKIRVPLKVVRTAENKLSNRFFPYDEIETEAVLAIDDDIIMLTSDELQFGYEVWREFPDRLVGYPGRLHLWDHEMNKWKYESEWTNEVSMVLTGAAFYHKYFNYLYTYKMPGDIKNWVDTHMNCEDIAMNFLVANVTGKAVIKVTPRKKFKCPECTAIDGLSLDQTHMVERSECINKFASVFGTMPLKVVEHRADPVLYKDDFPEKLKSFPNIGSL
uniprot
proteins
ec_number
2.4.1.224
uniprot
proteins
function
FUNCTION: Glycosyltransferase forming with EXT1 the heterodimeric heparan sulfate polymerase which catalyzes the elongation of the heparan sulfate glycan backbone. Glycan backbone extension consists in the alternating transfer of (1->4)-beta-D-GlcA and (1->4)-alpha-D-GlcNAc residues from their respective UDP-sugar donors (PubMed:10639137). Both EXT1 and EXT2 are required for the full activity of the polymerase since EXT1 bears the N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity within the complex while EXT2 carries the glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Heparan sulfate proteoglycans are ubiquitous components of the extracellular matrix and play an important role in tissue homeostasis and signaling (By similarity). {ECO:0000250|UniProtKB:Q93063, ECO:0000269|PubMed:10639137}.
uniprot
proteins
mass_dalton
82064
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:10639137}.
uniprot
proteins
post_translational_modification
PTM: N-glycosylated at Asn-637. {ECO:0000250|UniProtKB:Q93063}.; PTM: A soluble form is generated by proteolytic processing. {ECO:0000250|UniProtKB:O77783}.
uniprot
proteins
protein_family
Glycosyltransferase 47 family
uniprot
proteins
pubmed
10639137
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18337501
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
9110175
uniprot
proteins
pubmed
9232192
uniprot
proteins
sequence_length
718
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:10639137}; Single-pass type II membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q93063}; Single-pass type II membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q93063}; Single-pass type II membrane protein {ECO:0000255}. Secreted {ECO:0000250|UniProtKB:O77783}. Note=The active heparan sulfate polymerase complex composed of EXT1 and EXT2 is localized to the Golgi apparatus. If both proteins are individually detected in the endoplasmic reticulum, the formation of the complex promotes their transport to the Golgi. {ECO:0000269|PubMed:10639137}.
uniprot
proteins
transmembrane_region
TRANSMEM 26..46; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins