Bmp7
entrez
12162
canonical
uniprot
P23359
canonical
ensembl
ENSMUSG00000008999
resolver
ensp
ENSMUSP00000009143
resolver
enst
ENSMUST00000009143
resolver
genesymbol
Bmp7
resolver
genesymbol_syn
Bmp-7
resolver
genesymbol_syn
Op1
resolver
uniprot
Q91XF7
resolver
uniprot_entry
BMP7_MOUSE
resolver
uniprot_sec
Q91XF7
resolver
amino_acid_sequence
MHVRSLRAAAPHSFVALWAPLFLLRSALADFSLDNEVHSSFIHRRLRSQERREMQREILSILGLPHRPRPHLQGKHNSAPMFMLDLYNAMAVEESGPDGQGFSYPYKAVFSTQGPPLASLQDSHFLTDADMVMSFVNLVEHDKEFFHPRYHHREFRFDLSKIPEGEAVTAAEFRIYKDYIRERFDNETFQITVYQVLQEHSGRESDLFLLDSRTIWASEEGWLVFDITATSNHWVVNPRHNLGLQLSVETLDGQSINPKLAGLIGRHGPQNKQPFMVAFFKATEVHLRSIRSTGGKQRSQNRSKTPKNQEALRMASVAENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAAYYCEGECAFPLNSYMNATNHAIVQTLVHFINPDTVPKPCCAPTQLNAISVLYFDDSSNVILKKYRNMVVRACGCH
uniprot
proteins
function
FUNCTION: Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including embryogenesis, hematopoiesis, neurogenesis and skeletal morphogenesis (PubMed:22461901, PubMed:9013703). Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2A. Once all three components are bound together in a complex at the cell surface, ACVR2A phosphorylates and activates ACVR1. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. For specific functions such as growth cone collapse in developing spinal neurons and chemotaxis of monocytes, also uses BMPR2 as type II receptor. Can also signal through non-canonical pathways such as P38 MAP kinase signaling cascade that promotes brown adipocyte differentiation through activation of target genes, including members of the SOX family of transcription factors (By similarity). Promotes the expression of HAMP, this is repressed by its interaction with ERFE (PubMed:30097509). {ECO:0000250|UniProtKB:P18075, ECO:0000269|PubMed:22461901, ECO:0000269|PubMed:30097509, ECO:0000269|PubMed:9013703}.
uniprot
proteins
mass_dalton
49199
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
14623234
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15843411
uniprot
proteins
pubmed
1715687
uniprot
proteins
pubmed
22461901
uniprot
proteins
pubmed
30097509
uniprot
proteins
pubmed
9013703
uniprot
proteins
sequence_length
430
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
uniprot
proteins