Smpd4
entrez
77626
canonical
uniprot
Q6ZPR5
canonical
ensembl
ENSMUSG00000005899
resolver
ensp
ENSMUSP00000006053
resolver
ensp
ENSMUSP00000087620
resolver
ensp
ENSMUSP00000130720
resolver
ensp
ENSMUSP00000131867
resolver
ensp
ENSMUSP00000155897
resolver
ensp
ENSMUSP00000156215
resolver
ensp
ENSMUSP00000328951
resolver
genesymbol
Smpd4
resolver
genesymbol_syn
Kiaa1418
resolver
uniprot
Q3TPE0
resolver
uniprot
Q3TPP1
resolver
uniprot
Q8CBJ5
resolver
uniprot
Q8CD12
resolver
uniprot
Q8CD83
resolver
uniprot
Q8R0J3
resolver
uniprot
Q9CX74
resolver
uniprot_entry
NSMA3_MOUSE
resolver
uniprot_sec
Q3TPE0
resolver
uniprot_sec
Q3TPP1
resolver
uniprot_sec
Q8CBJ5
resolver
uniprot_sec
Q8CD12
resolver
uniprot_sec
Q8CD83
resolver
uniprot_sec
Q8R0J3
resolver
uniprot_sec
Q9CX74
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphatidylserine and tumor necrosis factor (TNF) (PubMed:25180167). Inhibited by scyphostatin (By similarity). {ECO:0000250|UniProtKB:Q9NXE4, ECO:0000269|PubMed:25180167}.
uniprot
proteins
amino_acid_sequence
MAFPHLQQPSFLLASLKADSINKPFAQRCQDLVKVIEDFPAKELHAVFPWLVESIFGSLDGVLVGWNLRCLQGRVNPVEYSTAMEFLDPSGPMMKLVYKLQAEDYNFDFPVSCLPGPVKASIQENVLPDSPLYHNKVQFPPTGGLGLNLALNPFEYYMFYFALSLISQKPMSMTLHVRTSDCAYFTLVDRYLSWFLPTEGSVPPPLCSSPGGSSPSPAPRTPAMPFASYGLHTSLLKRHISHQTSVNADPASHEIWRSETLLQVFVEMWLHHYSLEMYQKMQSPHAKLEVLHYRLTVSSALHSPAQPSLQALHAYQESFTPTEEHVLVVRLLLKHLHAFANSLKPDQASPSAHSHATSPLEEFKRAAVPRFVQQKLYVFLQHCFGHWPLDATFRAVLEMWLSYLQPWRYAPEKQAQGSDPQPRCVSEKWAPFIQENLLMYTKLFVSFLNRALRTDLVSPKNALMVFRVAKVFAQPNLAEMIQKGEQLFLEPELIIPHRQHRLFTVTTSFLSPWPPVVTDASFKVKSHVYSLEGQDCKYTPMFGPEIRTLVLRLAQLITQAKQTAKSISDQYVESPTGRSFLSWLTFGLTDTNSCYPANDLDEIGQDSIRKTDEYLEKALEYLRQIFRLSEAQLAQLTLALGSARDENGKQQLPDCIVGEEGLILTPLGRYQIINGLRRFEIEYQGDLELQPIRSYEITSLVRALFRLSSAINRRFAGQMAALCSRNDFLGSFCRYHLTEPALSNRHLLSPVGRRQVTNPARGPRLSLRFLGSYRTLLLLLMAFFVASLFCIGPLSCSLLLVLGYVLYAIAMTLLTERGKLHQL
uniprot
proteins
ec_number
3.1.4.12
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide (PubMed:25180167). It has a relevant role in the homeostasis of membrane sphingolipids, thereby influencing membrane integrity, and endoplasmic reticulum organization and function. May sensitize cells to DNA damage-induced apoptosis. In skeletal muscle, mediates TNF-stimulated oxidant production (PubMed:25180167). {ECO:0000250|UniProtKB:Q9NXE4, ECO:0000269|PubMed:25180167}.
uniprot
proteins
mass_dalton
93276
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25180167
uniprot
proteins
pubmed
31142202
uniprot
proteins
sequence_length
823
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:25180167}; Single-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9NXE4}; Single-pass membrane protein {ECO:0000255}. Nucleus envelope {ECO:0000269|PubMed:31142202}. Cell membrane, sarcolemma {ECO:0000269|PubMed:25180167}.
uniprot
proteins
transmembrane_region
TRANSMEM 776..796; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins