PRKACB
entrez
5567
canonical
uniprot
P22694
canonical
ensembl
ENSG00000142875
resolver
ensp
ENSP00000359714
resolver
ensp
ENSP00000359718
resolver
ensp
ENSP00000359719
resolver
ensp
ENSP00000359722
resolver
ensp
ENSP00000359723
resolver
ensp
ENSP00000378315
resolver
ensp
ENSP00000390906
resolver
ensp
ENSP00000392275
resolver
ensp
ENSP00000397175
resolver
ensp
ENSP00000399326
resolver
ensp
ENSP00000401252
resolver
ensp
ENSP00000479339
resolver
ensp
ENSP00000479722
resolver
ensp
ENSP00000481980
resolver
ensp
ENSP00000653542
resolver
ensp
ENSP00000653543
resolver
enst
ENST00000370680
resolver
enst
ENST00000370684
resolver
enst
ENST00000610457
resolver
genesymbol
PRKACB
resolver
hgnc
HGNC:9381
resolver
uniprot
A0A087WVC4
resolver
uniprot
B1APF9
resolver
uniprot
B1APG3
resolver
uniprot
B1APG4
resolver
uniprot
B2RB89
resolver
uniprot
B4DKB0
resolver
uniprot
B4E2Q1
resolver
uniprot
B7ZA00
resolver
uniprot
D3DT10
resolver
uniprot
Q14VH1
resolver
uniprot
Q59GC0
resolver
uniprot
Q5BNE9
resolver
uniprot
Q5BNF0
resolver
uniprot
Q5BNF1
resolver
uniprot
Q5BNF2
resolver
uniprot
Q5BNF3
resolver
uniprot
Q5CZ92
resolver
uniprot
Q5T1K3
resolver
uniprot
Q7Z3M1
resolver
uniprot
Q8IYR5
resolver
uniprot
Q8IZQ0
resolver
uniprot
Q96B09
resolver
uniprot_entry
A0A087WVC4_HUMAN
resolver
uniprot_entry
B1APF9_HUMAN
resolver
uniprot_entry
B1APG3_HUMAN
resolver
uniprot_entry
B2RB89_HUMAN
resolver
uniprot_entry
B7ZA00_HUMAN
resolver
uniprot_entry
KAPCB_HUMAN
resolver
uniprot_sec
B1APG4
resolver
uniprot_sec
B4DKB0
resolver
uniprot_sec
B4E2Q1
resolver
uniprot_sec
D3DT10
resolver
uniprot_sec
Q14VH1
resolver
uniprot_sec
Q59GC0
resolver
uniprot_sec
Q5BNE9
resolver
uniprot_sec
Q5BNF0
resolver
uniprot_sec
Q5BNF1
resolver
uniprot_sec
Q5BNF2
resolver
uniprot_sec
Q5BNF3
resolver
uniprot_sec
Q5CZ92
resolver
uniprot_sec
Q5T1K3
resolver
uniprot_sec
Q7Z3M1
resolver
uniprot_sec
Q8IYR5
resolver
uniprot_sec
Q8IZQ0
resolver
uniprot_sec
Q96B09
resolver
activity_regulation
ACTIVITY REGULATION: Activated by cAMP. {ECO:0000269|PubMed:33058759}.
uniprot
proteins
amino_acid_sequence
MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF
uniprot
proteins
disease_involvement
DISEASE: Cardioacrofacial dysplasia 2 (CAFD2) [MIM:619143]: An autosomal dominant disease characterized by dysmorphic facial features, congenital cardiac defects, primarily common atrium or atrioventricular septal defect, and limb anomalies, including short limbs, brachydactyly and postaxial polydactyly. CAFD2 patients may show developmental delay of variable severity, intellectual disability, autistic features and focal seizures. {ECO:0000269|PubMed:33058759}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.11.11
uniprot
proteins
function
FUNCTION: Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs (PubMed:12420224, PubMed:21423175, PubMed:31112131). PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux (PubMed:12420224, PubMed:21423175). Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (PubMed:12420224, PubMed:21423175). Phosphorylates GPKOW which regulates its ability to bind RNA (PubMed:21880142). Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR (PubMed:31112131). {ECO:0000269|PubMed:12420224, ECO:0000269|PubMed:21423175, ECO:0000269|PubMed:21880142, ECO:0000269|PubMed:31112131}.
uniprot
proteins
mass_dalton
40623
uniprot
proteins
post_translational_modification
PTM: Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively. {ECO:0000250|UniProtKB:P05383}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
cAMP subfamily
uniprot
proteins
pubmed
11589697
uniprot
proteins
pubmed
12420224
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21423175
uniprot
proteins
pubmed
21880142
uniprot
proteins
pubmed
2342480
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25255805
uniprot
proteins
pubmed
31112131
uniprot
proteins
pubmed
33058759
uniprot
proteins
sequence_length
351
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21423175}. Cell membrane {ECO:0000269|PubMed:21423175}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Nucleus {ECO:0000250|UniProtKB:P05131}. Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm. {ECO:0000250|UniProtKB:P05131}.
uniprot
proteins