STX11
entrez
8676
canonical
uniprot
O75558
canonical
ensembl
ENSG00000135604
resolver
ensp
ENSP00000356540
resolver
ensp
ENSP00000513678
resolver
ensp
ENSP00000513679
resolver
ensp
ENSP00000513680
resolver
ensp
ENSP00000542570
resolver
ensp
ENSP00000542571
resolver
ensp
ENSP00000542572
resolver
ensp
ENSP00000542573
resolver
ensp
ENSP00000542574
resolver
ensp
ENSP00000542575
resolver
ensp
ENSP00000542576
resolver
ensp
ENSP00000542577
resolver
ensp
ENSP00000542578
resolver
ensp
ENSP00000621939
resolver
ensp
ENSP00000621940
resolver
ensp
ENSP00000621941
resolver
ensp
ENSP00000621942
resolver
enst
ENST00000367568
resolver
enst
ENST00000698355
resolver
enst
ENST00000698356
resolver
enst
ENST00000698357
resolver
enst
ENST00000872511
resolver
enst
ENST00000872512
resolver
enst
ENST00000872513
resolver
enst
ENST00000872514
resolver
enst
ENST00000872515
resolver
enst
ENST00000872516
resolver
enst
ENST00000872517
resolver
enst
ENST00000872518
resolver
enst
ENST00000872519
resolver
enst
ENST00000951880
resolver
enst
ENST00000951881
resolver
enst
ENST00000951882
resolver
enst
ENST00000951883
resolver
genesymbol
STX11
resolver
hgnc
HGNC:11429
resolver
uniprot
E1P598
resolver
uniprot
O75378
resolver
uniprot
O95148
resolver
uniprot
Q5TCL6
resolver
uniprot_entry
STX11_HUMAN
resolver
uniprot_sec
E1P598
resolver
uniprot_sec
O75378
resolver
uniprot_sec
O95148
resolver
uniprot_sec
Q5TCL6
resolver
amino_acid_sequence
MKDRLAELLDLSKQYDQQFPDGDDEFDSPHEDIVFETDHILESLYRDIRDIQDENQLLVADVKRLGKQNARFLTSMRRLSSIKRDTNSIAKAIKARGEVIHCKLRAMKELSEAAEAQHGPHSAVARISRAQYNALTLTFQRAMHDYNQAEMKQRDNCKIRIQRQLEIMGKEVSGDQIEDMFEQGKWDVFSENLLADVKGARAALNEIESRHRELLRLESRIRDVHELFLQMAVLVEKQADTLNVIELNVQKTVDYTGQAKAQVRKAVQYEEKNPCRTLCCFCCPCLK
uniprot
proteins
disease_involvement
DISEASE: Hemophagocytic lymphohistiocytosis, familial, 4 (FHL4) [MIM:603552]: A rare disorder characterized by immune dysregulation with hypercytokinemia, defective function of natural killer cell, and massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits and ataxia. {ECO:0000269|PubMed:15703195, ECO:0000269|PubMed:16582076, ECO:0000269|PubMed:24459464}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: SNAREs (soluble N-ethylmaleimide-sensitive factor-attachment protein receptors) are essential proteins for intracellular membrane fusion. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four-helix bundle whose assembly releases energy that drives membrane fusion. The core SNARE complex typically consists of four alpha-helical domains, three from target membrane SNAREs (t-SNAREs) and one from a vesicle SNARE (v-SNARE) (PubMed:10036234, PubMed:24227526, PubMed:26771955, PubMed:28265073). Syntaxin-11/STX11 is an atypical lipid-anchored t-SNARE that forms a SNARE complex with the t-SNARE SNAP23 and the v-SNARE VAMP8. This SNARE complex plays a critical role in the regulated exocytosis of cytotoxic granules by natural killer (NK) cells and cytotoxic T-lymphocytes (PubMed:17525286, PubMed:19804848, PubMed:19884660, PubMed:24227526, PubMed:26771955, PubMed:28265073). In macrophages, STX11 regulates stimulus-dependent vesicular transport of TLR4 from recycling endosomes to the plasma membrane by cooperating with SNAP23, thereby playing a critical role in microbial component recognition and the induction of innate and adaptive immunity (By similarity). In skeletal muscle satellite cells, STX11 cooperates with its cognate SNAREs VAMP4 and SNAP23 to facilitate CD36 vesicular transport from endosomes to the plasma membrane, an essential step in muscle regeneration (By similarity). In another proposed mechanism, STX11 may function as a regulator of the SNARE VTI1B on late endosomes to regulate trafficking from late endosomes to lysosomes (PubMed:21388490). {ECO:0000250|UniProtKB:Q9D3G5, ECO:0000269|PubMed:10036234, ECO:0000269|PubMed:17525286, ECO:0000269|PubMed:19804848, ECO:0000269|PubMed:19884660, ECO:0000269|PubMed:21388490, ECO:0000269|PubMed:24227526, ECO:0000269|PubMed:26771955, ECO:0000269|PubMed:28265073}.
uniprot
proteins
mass_dalton
33196
uniprot
proteins
mutagenesis
MUTAGEN 279..285; /note="CCFCCPC->AFAAPA: Loss of association with membranes."; /evidence="ECO:0000269|PubMed:24910990
uniprot
proteins
post_translational_modification
PTM: Palmitoylation by ZDHHC20 releases STX11 from a locked inactive conformation, facilitating the formation of the STX11/SNAP23/VAMP4 SNARE complex and the subsequent fusion of membranes. STX11 is depalmitoylated by ABDHD17A. Palmitoylation and depalmitoylation of STX11 regulate its activity in vesicular transport from endosomes to the plasma membrane (By similarity). The palmitoylation of STX11 is also responsible for its membrane association and localization to the immunological synapse (PubMed:24910990). {ECO:0000250|UniProtKB:Q9D3G5, ECO:0000269|PubMed:24910990}.
uniprot
proteins
protein_family
Syntaxin family
uniprot
proteins
pubmed
10036234
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15703195
uniprot
proteins
pubmed
16582076
uniprot
proteins
pubmed
17525286
uniprot
proteins
pubmed
19804848
uniprot
proteins
pubmed
19884660
uniprot
proteins
pubmed
21388490
uniprot
proteins
pubmed
24227526
uniprot
proteins
pubmed
24459464
uniprot
proteins
pubmed
24910990
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26771955
uniprot
proteins
pubmed
28265073
uniprot
proteins
pubmed
9553086
uniprot
proteins
pubmed
9571206
uniprot
proteins
sequence_length
287
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24227526, ECO:0000269|PubMed:26771955}; Lipid-anchor {ECO:0000269|PubMed:10036234, ECO:0000269|PubMed:15703195, ECO:0000269|PubMed:21388490, ECO:0000269|PubMed:24910990}. Late endosome membrane {ECO:0000269|PubMed:10036234, ECO:0000269|PubMed:21388490}. Note=Palmitoylation participates to membrane anchorage (PubMed:10036234, PubMed:15703195, PubMed:24910990). Localizes at the immunological synapse in activated immune cells (PubMed:24910990, PubMed:26771955). Detected in trans-Golgi network, recycling and late endosomes when overexpressed (PubMed:10036234, PubMed:21388490). {ECO:0000269|PubMed:10036234, ECO:0000269|PubMed:15703195, ECO:0000269|PubMed:21388490, ECO:0000269|PubMed:24910990, ECO:0000269|PubMed:26771955}.
uniprot
proteins