Tssk4
entrez
71099
canonical
uniprot
Q9D411
canonical
ensembl
ENSMUSG00000007591
resolver
ensp
ENSMUSP00000007735
resolver
ensp
ENSMUSP00000153752
resolver
ensp
ENSMUSP00000154783
resolver
genesymbol
Tssk4
resolver
genesymbol_syn
Tssk5
resolver
uniprot
A3QQQ9
resolver
uniprot
A3QQR0
resolver
uniprot
A3QQR1
resolver
uniprot
A9P6P7
resolver
uniprot
A9P6P9
resolver
uniprot
Q9DA58
resolver
uniprot_entry
TSSK4_MOUSE
resolver
uniprot_sec
A3QQQ9
resolver
uniprot_sec
A3QQR0
resolver
uniprot_sec
A3QQR1
resolver
uniprot_sec
A9P6P7
resolver
uniprot_sec
A9P6P9
resolver
uniprot_sec
Q9DA58
resolver
activity_regulation
ACTIVITY REGULATION: Activated by autophosphorylation on Thr-197. {ECO:0000269|PubMed:23054012}.
uniprot
proteins
amino_acid_sequence
MGKGDTSETASATPAYRSVMEEYGYEVGKIIGHGSYGTVYEAYYTKQKVMVAVKIISKKKASEDYLNKFLPREIQVMKVLRHKYLINFYQAIETTSRVYIILELAQGGDVLEWIQRYGACAETLAGKWFSQMALGIAYLHSKGIVHRDLKLENLLLDKRENVKISDFGFAKMVPSSQPVHSSPSYRQMNSLSHLSQTYCGSFAYACPEILLGLPYNPFLSDTWSMGVILYTLVVARLPFDDTNLKKLLRETQKEVTFPANLTISQECKNLILQLLRQSTKRATILDVLRDPWMLKFQPEQPSNEIRLLEAMYQPTSSAKRHQSLEITT
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: [Isoform 1]: Serine/threonine kinase which is involved in male germ cell development and in mature sperm function (PubMed:17927909, PubMed:23054012, PubMed:23599433, PubMed:25361759, PubMed:26940607). May be involved in the Cre/Creb signaling pathway (PubMed:26940607). Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells (By similarity). Phosphorylates CREM on 'Ser-116' in vitro (PubMed:26940607). Phosphorylates ODF2 on 'Ser-95' (PubMed:26961893). {ECO:0000250|UniProtKB:Q6SA08, ECO:0000269|PubMed:17927909, ECO:0000269|PubMed:23054012, ECO:0000269|PubMed:23599433, ECO:0000269|PubMed:25361759, ECO:0000269|PubMed:26940607, ECO:0000269|PubMed:26961893}.; FUNCTION: [Isoform 2]: Catalytically inactive. {ECO:0000269|PubMed:17927909}.; FUNCTION: [Isoform 3]: Catalytically inactive. {ECO:0000269|PubMed:17927909}.; FUNCTION: [Isoform 4]: Catalytically inactive. {ECO:0000269|PubMed:17927909}.
uniprot
proteins
mass_dalton
37377
uniprot
proteins
mutagenesis
MUTAGEN 54; /note="K->M: Loss of kinase activity and no phosphorylation of ODF2. No effect on interaction with ODF2."; /evidence="ECO:0000269|PubMed:25361759, ECO:0000269|PubMed:26940607"; MUTAGEN 197; /note="T->A: Loss of kinase activity and no phosphorylation of ODF2. No effect on interaction with ODF2."; /evidence="ECO:0000269|PubMed:25361759
uniprot
proteins
post_translational_modification
PTM: Activated by autophosphorylation on Thr-197. ODF2 potentiates the autophosphorylation activity of TSSK4 at Thr-197. {ECO:0000269|PubMed:23054012, ECO:0000269|PubMed:26940607}.; PTM: Ubiquitinated; HSP90 activity negatively regulates ubiquitination and degradation. {ECO:0000269|PubMed:23599433}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17927909
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20729278
uniprot
proteins
pubmed
23054012
uniprot
proteins
pubmed
23599433
uniprot
proteins
pubmed
25361759
uniprot
proteins
pubmed
26940607
uniprot
proteins
pubmed
26961893
uniprot
proteins
sequence_length
328
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:20729278}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:20729278, ECO:0000269|PubMed:23054012, ECO:0000269|PubMed:25361759}. Note=In spermatozoa, present in the sperm head and in the flagellum. {ECO:0000269|PubMed:20729278}.
uniprot
proteins