Esyt2
entrez
52635
canonical
uniprot
Q3TZZ7
canonical
ensembl
ENSMUSG00000021171
resolver
ensp
ENSMUSP00000098548
resolver
ensp
ENSMUSP00000186833
resolver
ensp
ENSMUSP00000186835
resolver
ensp
ENSMUSP00000186836
resolver
ensp
ENSMUSP00000186839
resolver
ensp
ENSMUSP00000186842
resolver
ensp
ENSMUSP00000186853
resolver
genesymbol
Esyt2
resolver
genesymbol_syn
D12Ertd551e
resolver
genesymbol_syn
Fam62b
resolver
uniprot
B2RSN5
resolver
uniprot
Q9D5Y7
resolver
uniprot_entry
ESYT2_MOUSE
resolver
uniprot_sec
B2RSN5
resolver
uniprot_sec
Q9D5Y7
resolver
amino_acid_sequence
MSSAGGEGPEAGPGRAGGRSEPEAPGSALSVDLPGLLGQLARSFALLLPVYALGYLGLSFSWVLLALGLLAWCRRSRGLKASRLCRALALLEDEEQAVRLGVRACDLPAWVHFPDTERAEWLNKTVKHMWPFICQFIEKLFRETIEPAVRGANAHLSTFSFTKVDVGQQPLRVNGVKVYTENVDKRQIILDLQISFVGNCEIDLEIKRYFCRAGVKSIQIHGTMRVILEPLIGDMPLVGALSIFFLRKPLLEINWTGLTNLLDIPGLNGLSDTIILDIISNYLVLPNRITVPLVSEVQIAQLRFPIPKGVLRIHFIEAQDLQGKDTYLKGLVKGKSDPYGIIRVGNQIFQSKVIKENLSPKWNEVYEALVYEHPGQELEIELFDEDPDKDDFLGSLMIDLIEVEKERLLDEWFTLDEVPKGKLHLKLEWLTLMPDAANLDKVLADIRADKDQASDGLSSALLILYLDSARNLPSGKKINSNPNPLVQMSVGHKAQESKIRYKTSEPVWEENFTFFIHNPRRQDLEVEVKDEQHQCSLGSLRIPLSQLLTSDNMTINQRFQLSNSGPNSTLKMKIALRVLHLEKQERPPDYQHSAQVKRPSVSKEGRKMPIKSQMSASPGTGGANTAPSTPVMGVDDKPAMEEKPQPPEASPLGHRDLGRSSSSLLASPSHIAAKEPTPSIASDISLPIATQELRQRLRQLENGTTLGQSPLGQIQLTIRHSSQRNKLIVVVHSCRNLIAFSEDGSDPYVRMYLLPDKRRSGRRKTHVSKKTLNPVFDQSFDFSVSLPEVQRRTLDVAVKNSGGFLSKDKGLLGKVLVVLASEELAKGWTQWYDLTEDGTRPQVIT
uniprot
proteins
function
FUNCTION: Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex (By similarity). Promotes the localization of SACM1L at endoplasmic reticulum-plasma membrane contact sites (EPCS) (By similarity). {ECO:0000250|UniProtKB:A0FGR8}.
uniprot
proteins
mass_dalton
94139
uniprot
proteins
protein_family
Extended synaptotagmin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18977228
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
845
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:A0FGR8}; Peripheral membrane protein {ECO:0000250|UniProtKB:A0FGR8}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:A0FGR8}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS). Recruited to the cell membrane via the third C2 domain (By similarity). {ECO:0000250|UniProtKB:A0FGR8}.
uniprot
proteins
transmembrane_region
TRANSMEM 28..48; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 52..72; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins