Amh
entrez
25378
canonical
uniprot
P49000
canonical
ensembl
ENSRNOG00000019377
resolver
ensembl
ENSRNOG00055031425
resolver
ensembl
ENSRNOG00060024653
resolver
ensembl
ENSRNOG00065018204
resolver
ensp
ENSRNOP00000026220
resolver
ensp
ENSRNOP00055044981
resolver
ensp
ENSRNOP00060035327
resolver
ensp
ENSRNOP00065024257
resolver
enst
ENSRNOT00000026220
resolver
enst
ENSRNOT00055054410
resolver
enst
ENSRNOT00060042646
resolver
enst
ENSRNOT00065030500
resolver
genesymbol
Amh
resolver
uniprot_entry
AMH_RAT
resolver
amino_acid_sequence
MQGPHLSLLLLLLATMGAVLQADTVEELTNTRGLIFLEDGVWPPSSPPEPLCLVAVRGEGDTSKASLTVVGGLHSYEHAFLEAVQESRWGPQDLATFGVCSTDSQTTLPALQRLGAWLGETGEQQLLVLHLAEVIWEPQLLLKFQEPPPGGASRWEQALLVLYPGPGPQVTVTGAGLQGTQSLCPTRDTRYLVLTVHFPAGAWSGSGLALTLQPSKEGATLTIAQLQAFLFGSDSRCFTRMTPTLVLLPPTGPTPQPAHGQLDTVPFPQPGLSLEPEDLPHSADPFLETLTRLVRALRGPLTRASNTRLALDPGALASFPQGLVNLSDPVALGRLLDGEEPLLLLLSPAAATVGEPMRLHSPTSAPWAAGLARRVAVELQAAASELRDLPGLPPTAPPLLSRLLALCPNDSRSAGDPLRALLLLKALQGLRAEWRGREGRGRAGRSKGTGTDGLCALRELSVDLRAERSVLIPETYQANNCQGACAWPQSDRNPRYGNHVVLLLKMQARGAALGRLPCCVPTAYTGKLLISLSEEHISAHHVPNMVATECGCR
uniprot
proteins
function
FUNCTION: The anti-Muellerian hormone (AMH) plays an important role in several reproductive functions (By similarity). Anti-Muellerian hormone binds and activates AMHR2, its specific type-II receptor, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A) to regulate target gene expression through downstream SMAD protein signal transduction (By similarity). Produced and secreted by Sertoli cells of the male fetus, anti-Muellerian hormone induces Muellerian duct regression during male fetal sexual differentiation (By similarity). In female, it is produced by granulosa cells of the preantral and small antral follicles and acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles (By similarity). Also plays a role in Leydig cell differentiation and function (By similarity). {ECO:0000250|UniProtKB:P03971, ECO:0000250|UniProtKB:P27106}.
uniprot
proteins
mass_dalton
58889
uniprot
proteins
post_translational_modification
PTM: The preproprotein is proteolytically processed to generate the AMH prodomain and the anti-Muellerian hormone (By similarity). Both homodimerize covalently, and homodimers associate to form a non-covalent heterotetrameric complex (By similarity). {ECO:0000250|UniProtKB:P03971}.
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
1572639
uniprot
proteins
pubmed
7588229
uniprot
proteins
sequence_length
553
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P03971}.
uniprot
proteins