Dkk1
entrez
13380
canonical
uniprot
O54908
canonical
ensembl
ENSMUSG00000024868
resolver
ensp
ENSMUSP00000025803
resolver
enst
ENSMUST00000025803
resolver
genesymbol
Dkk1
resolver
uniprot
Q80UL5
resolver
uniprot_entry
DKK1_MOUSE
resolver
uniprot_sec
Q80UL5
resolver
amino_acid_sequence
MMVVCAAAAVRFLAVFTMMALCSLPLLGASATLNSVLINSNAIKNLPPPLGGAGGQPGSAVSVAPGVLYEGGNKYQTLDNYQPYPCAEDEECGSDEYCSSPSRGAAGVGGVQICLACRKRRKRCMRHAMCCPGNYCKNGICMPSDHSHFPRGEIEESIIENLGNDHNAAAGDGYPRRTTLTSKIYHTKGQEGSVCLRSSDCAAGLCCARHFWSKICKPVLKEGQVCTKHKRKGSHGLEIFQRCYCGEGLACRIQKDHHQASNSSRLHTCQRH
uniprot
proteins
function
FUNCTION: Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6 (PubMed:18524778). Inhibits the pro-apoptotic function of KREMEN1 in a Wnt-independent manner, and has anti-apoptotic activity (PubMed:26206087). Plays a role in limb development; attenuates Wnt signaling in the developing limb to allow normal limb patterning (PubMed:18505822). {ECO:0000269|PubMed:18505822, ECO:0000269|PubMed:18524778, ECO:0000269|PubMed:26206087}.
uniprot
proteins
mass_dalton
29298
uniprot
proteins
mutagenesis
MUTAGEN 210; /note="H->E: 50% reduced binding to LRP6."; /evidence="ECO:0000269|PubMed:18524778"; MUTAGEN 217; /note="K->E: 50% reduced binding to LRP6."; /evidence="ECO:0000269|PubMed:18524778"; MUTAGEN 242; /note="R->E: 50% reduced binding to LRP6."; /evidence="ECO:0000269|PubMed:18524778"; MUTAGEN 267; /note="H->E: 43% reduced binding to LRP6."; /evidence="ECO:0000269|PubMed:18524778
uniprot
proteins
protein_family
Dickkopf family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17143291
uniprot
proteins
pubmed
18505822
uniprot
proteins
pubmed
18524778
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
26206087
uniprot
proteins
pubmed
27550540
uniprot
proteins
pubmed
9450748
uniprot
proteins
sequence_length
272
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins