KIF4A
entrez
24137
canonical
uniprot
O95239
canonical
ensembl
ENSG00000090889
resolver
ensp
ENSP00000363524
resolver
genesymbol
KIF4A
resolver
genesymbol_syn
KIF4
resolver
hgnc
HGNC:13339
resolver
uniprot
B2R7V5
resolver
uniprot
D3DVU4
resolver
uniprot
Q59HG1
resolver
uniprot
Q86TN3
resolver
uniprot
Q86XX7
resolver
uniprot
Q9NNY6
resolver
uniprot
Q9NY24
resolver
uniprot
Q9UMW3
resolver
uniprot_entry
KIF4A_HUMAN
resolver
uniprot_entry
Q59HG1_HUMAN
resolver
uniprot_sec
B2R7V5
resolver
uniprot_sec
D3DVU4
resolver
uniprot_sec
Q86TN3
resolver
uniprot_sec
Q86XX7
resolver
uniprot_sec
Q9NNY6
resolver
uniprot_sec
Q9NY24
resolver
uniprot_sec
Q9UMW3
resolver
amino_acid_sequence
MKEEVKGIPVRVALRCRPLVPKEISEGCQMCLSFVPGEPQVVVGTDKSFTYDFVFDPSTEQEEVFNTAVAPLIKGVFKGYNATVLAYGQTGSGKTYSMGGAYTAEQENEPTVGVIPRVIQLLFKEIDKKSDFEFTLKVSYLEIYNEEILDLLCPSREKAQINIREDPKEGIKIVGLTEKTVLVALDTVSCLEQGNNSRTVASTAMNSQSSRSHAIFTISLEQRKKSDKNSSFRSKLHLVDLAGSERQKKTKAEGDRLKEGININRGLLCLGNVISALGDDKKGGFVPYRDSKLTRLLQDSLGGNSHTLMIACVSPADSNLEETLNTLRYADRARKIKNKPIVNIDPQTAELNHLKQQVQQLQVLLLQAHGGTLPGSITVEPSENLQSLMEKNQSLVEENEKLSRGLSEAAGQTAQMLERIILTEQANEKMNAKLEELRQHAACKLDLQKLVETLEDQELKENVEIICNLQQLITQLSDETVACMAAAIDTAVEQEAQVETSPETSRSSDAFTTQHALRQAQMSKELVELNKALALKEALARKMTQNDSQLQPIQYQYQDNIKELELEVINLQKEKEELVLELQTAKKDANQAKLSERRRKRLQELEGQIADLKKKLNEQSKLLKLKESTERTVSKLNQEIRMMKNQRVQLMRQMKEDAEKFRQWKQKKDKEVIQLKERDRKRQYELLKLERNFQKQSNVLRRKTEEAAAANKRLKDALQKQREVADKRKETQSRGMEGTAARVKNWLGNEIEVMVSTEEAKRHLNDLLEDRKILAQDVAQLKEKKESGENPPPKLRRRTFSLTEVRGQVSESEDSITKQIESLETEMEFRSAQIADLQQKLLDAESEDRPKQRWENIATILEAKCALKYLIGELVSSKIQVSKLESSLKQSKTSCADMQKMLFEERNHFAEIETELQAELVRMEQQHQEKVLYLLSQLQQSQMAEKQLEESVSEKEQQLLSTLKCQDEELEKMREVCEQNQQLLRENEIIKQKLTLLQVASRQKHLPKDTLLSPDSSFEYVPPKPKPSRVKEKFLEQSMDIEDLKYCSEHSVNEHEDGDGDDDEGDDEEWKPTKLVKVSRKNIQGCSCKGWCGNKQCGCRKQKSDCGVDCCCDPTKCRNRQQGKDSLGTVERTQDSEGSFKLEDPTEVTPGLSFFNPVCATPNSKILKEMCDVEQVLSKKTPPAPSPFDLPELKHVATEYQENKAPGKKKKRALASNTSFFSGCSPIEEEAH
uniprot
proteins
disease_involvement
DISEASE: Intellectual developmental disorder, X-linked 100 (XLID100) [MIM:300923]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked forms, while syndromic forms present with associated physical, neurological and/or psychiatric manifestations. XLID100 clinical features include intellectual disability, epilepsy, microcephaly and cortical malformations. {ECO:0000269|PubMed:24812067}. Note=The disease may be caused by variants affecting the gene represented in this entry.; DISEASE: Taurodontism, microdontia, and dens invaginatus (TMDI) [MIM:313490]: An X-linked recessive disorder characterized by the triad of taurodontism, microdontia, and dens invaginatus. Taurodontism is a rare developmental dental condition that largely affects the molar teeth and may be associated with hypodontia. In taurodontism, the crown of the molar tooth and pulp chamber are disproportionately longer than the roots. Microdontia, a mild form of hypodontia, is defined as smaller than normal teeth with shortened crowns (vertically or mesio-distally) and loss of contact areas between the teeth. Dens invaginatus or dens invagination is a tooth developmental anomaly that results from either the dental papilla folding into the developing tooth or the entire enamel organ folding into the dental papilla. In both instances, this leads to the formation of a tooth within a tooth. {ECO:0000269|PubMed:31616463}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Iron-sulfur (Fe-S) cluster binding motor protein that has a role in chromosome segregation during mitosis (PubMed:29848660). Translocates PRC1 to the plus ends of interdigitating spindle microtubules during the metaphase to anaphase transition, an essential step for the formation of an organized central spindle midzone and midbody and for successful cytokinesis (PubMed:15297875, PubMed:15625105). May play a role in mitotic chromosomal positioning and bipolar spindle stabilization (By similarity). {ECO:0000250|UniProtKB:P33174, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}.
uniprot
proteins
mass_dalton
139881
uniprot
proteins
mutagenesis
MUTAGEN 1086..1144; /note="Missing: Diffuse localization and does not localize to the spindle midzone or midbody during anaphase and telophase. Does not affect the interaction with PRC1."; /evidence="ECO:0000269|PubMed:29848660"; MUTAGEN 1106; /note="C->A: Abolishes chromatin localization; in association with A-1110 and A-1112."; /evidence="ECO:0000269|PubMed:29848660"; MUTAGEN 1110; /note="C->A: Abolishes chromatin localization; in association with A-1106 and A-1112."; /evidence="ECO:0000269|PubMed:29848660"; MUTAGEN 1112; /note="C->A: Abolishes chromatin localization; in association with A-1106 and A-1110."; /evidence="ECO:0000269|PubMed:29848660
uniprot
proteins
protein_family
Chromokinesin subfamily
uniprot
proteins
protein_family
Kinesin family
uniprot
proteins
protein_family
TRAFAC class myosin-kinesin ATPase superfamily
uniprot
proteins
pubmed
10978527
uniprot
proteins
pubmed
11736643
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15297875
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15625105
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24812067
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
29848660
uniprot
proteins
pubmed
31616463
uniprot
proteins
pubmed
9168136
uniprot
proteins
sequence_length
1232
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000269|PubMed:11736643}. Cytoplasm {ECO:0000269|PubMed:11736643}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:29848660}. Midbody {ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:29848660}. Chromosome {ECO:0000269|PubMed:11736643, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:29848660}. Note=Associates with chromosomes at all stage of mitosis (PubMed:11736643, PubMed:15297875, PubMed:15625105). Chromatin localization is dependent on iron-sulfur cluster binding (PubMed:29848660). In anaphase, associates with the mitotic spindle midzone (PubMed:15297875). In telophase and cytokinesis, co-localizes with CIAO2B at the spindle midzone and midbody (PubMed:15297875, PubMed:29848660). Co-localizes with PRC1 in early mitosis and at the spindle midzone from anaphase B to telophase (PubMed:15297875, PubMed:15625105). Does not localize to the nucleolus (PubMed:11736643). {ECO:0000269|PubMed:11736643, ECO:0000269|PubMed:15297875, ECO:0000269|PubMed:15625105, ECO:0000269|PubMed:29848660}.
uniprot
proteins