SLC35G1
entrez
159371
canonical
uniprot
Q2M3R5
canonical
ensembl
ENSG00000176273
resolver
ensp
ENSP00000360462
resolver
ensp
ENSP00000400932
resolver
ensp
ENSP00000569894
resolver
genesymbol
SLC35G1
resolver
genesymbol_syn
C10orf60
resolver
genesymbol_syn
POST
resolver
genesymbol_syn
TMEM20
resolver
hgnc
HGNC:26607
resolver
uniprot
B7ZKP0
resolver
uniprot
Q86YG5
resolver
uniprot
Q8NBA5
resolver
uniprot_entry
B7ZKP0_HUMAN
resolver
uniprot_entry
S35G1_HUMAN
resolver
uniprot_sec
Q86YG5
resolver
uniprot_sec
Q8NBA5
resolver
activity_regulation
ACTIVITY REGULATION: Citrate transport is inhibited by chloride ions at physiologically extracellular concentrations. {ECO:0000269|PubMed:39508819}.
uniprot
proteins
amino_acid_sequence
MRPQDSTGVAELQEPGLPLTDDAPPGATEEPAAAEAAGAPDRGRCWLCLSSPCCSRTEPEAKKKAPCPGLGLFYTLLSAFLFSVGSLFVKKVQDVHAVEISAFRCVFQMLVVIPCLIYRKTGFIGPKGQRIFLILRGVLGSTAMMLIYYAYQTMSLADATVITFSSPVFTSIFAWICLKEKYSPWDALFTVFTITGVILIVRPPFLFGSDTSGMEESYSGHLKGTFAAIGSAVFAASTLVILRKMGKSVDYFLSIWYYVVLGLVESVIILSVLGEWSLPYCGLDRLFLIFIGLFGLGGQIFITKALQIEKAGPVAIMKTMDVVFAFIFQIIFFNNVPTWWTVGGALCVVASNVGAAIRKWYQSSK
uniprot
proteins
function
FUNCTION: Chloride-sensitive citrate transporter localized on the basolateral membrane of enterocytes that mediates efflux of citrate into the bloodstream (PubMed:39508819). May also play a role in intracellular calcium sensing and homeostasis by acting as a negative regulator of plasma membrane calcium-transporting ATPases, thereby preventing calcium efflux from the cell (PubMed:22084111). {ECO:0000269|PubMed:22084111, ECO:0000269|PubMed:39508819}.
uniprot
proteins
mass_dalton
39836
uniprot
proteins
protein_family
SLC35G solute transporter family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22084111
uniprot
proteins
pubmed
39508819
uniprot
proteins
sequence_length
365
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:39508819}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:22084111}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:22084111}; Multi-pass membrane protein {ECO:0000255}. Note=Translocates from the endoplasmic reticulum to the cell membrane in response to a depletion of intracellular calcium and is detected at punctae corresponding to junctions between the endoplasmic reticulum and the cell membrane. {ECO:0000269|PubMed:22084111}.
uniprot
proteins
transmembrane_region
TRANSMEM 69..89; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 97..117; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 131..151; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 156..176; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 187..207; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 222..242; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 252..272; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 286..306; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 311..333; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 338..357; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins