SERPINB6
entrez
5269
canonical
uniprot
P35237
canonical
ensembl
ENSG00000124570
resolver
ensp
ENSP00000369891
resolver
ensp
ENSP00000369896
resolver
ensp
ENSP00000369901
resolver
ensp
ENSP00000369912
resolver
ensp
ENSP00000369919
resolver
ensp
ENSP00000481398
resolver
ensp
ENSP00000484343
resolver
ensp
ENSP00000493936
resolver
ensp
ENSP00000494161
resolver
ensp
ENSP00000494650
resolver
ensp
ENSP00000495362
resolver
ensp
ENSP00000496073
resolver
ensp
ENSP00000530536
resolver
ensp
ENSP00000530537
resolver
ensp
ENSP00000530539
resolver
ensp
ENSP00000530540
resolver
ensp
ENSP00000530542
resolver
ensp
ENSP00000530543
resolver
ensp
ENSP00000530544
resolver
ensp
ENSP00000530545
resolver
ensp
ENSP00000530546
resolver
ensp
ENSP00000530547
resolver
ensp
ENSP00000530548
resolver
ensp
ENSP00000530549
resolver
ensp
ENSP00000530550
resolver
ensp
ENSP00000530551
resolver
ensp
ENSP00000530552
resolver
ensp
ENSP00000530553
resolver
ensp
ENSP00000530554
resolver
ensp
ENSP00000530556
resolver
ensp
ENSP00000530557
resolver
ensp
ENSP00000530558
resolver
ensp
ENSP00000530559
resolver
ensp
ENSP00000530560
resolver
ensp
ENSP00000530561
resolver
ensp
ENSP00000530562
resolver
ensp
ENSP00000530563
resolver
ensp
ENSP00000530564
resolver
ensp
ENSP00000530565
resolver
ensp
ENSP00000530566
resolver
ensp
ENSP00000530567
resolver
ensp
ENSP00000530568
resolver
ensp
ENSP00000530569
resolver
ensp
ENSP00000530570
resolver
ensp
ENSP00000530571
resolver
ensp
ENSP00000530572
resolver
ensp
ENSP00000530573
resolver
ensp
ENSP00000530574
resolver
ensp
ENSP00000592647
resolver
ensp
ENSP00000592648
resolver
ensp
ENSP00000592649
resolver
ensp
ENSP00000620870
resolver
ensp
ENSP00000620871
resolver
ensp
ENSP00000620872
resolver
ensp
ENSP00000620873
resolver
ensp
ENSP00000620874
resolver
ensp
ENSP00000620875
resolver
ensp
ENSP00000620876
resolver
ensp
ENSP00000620877
resolver
ensp
ENSP00000620878
resolver
ensp
ENSP00000620879
resolver
ensp
ENSP00000620880
resolver
ensp
ENSP00000620881
resolver
ensp
ENSP00000620882
resolver
ensp
ENSP00000620883
resolver
ensp
ENSP00000620884
resolver
ensp
ENSP00000620885
resolver
ensp
ENSP00000620886
resolver
ensp
ENSP00000620887
resolver
ensp
ENSP00000620888
resolver
ensp
ENSP00000620889
resolver
ensp
ENSP00000620890
resolver
ensp
ENSP00000620891
resolver
ensp
ENSP00000620892
resolver
ensp
ENSP00000620893
resolver
ensp
ENSP00000620894
resolver
ensp
ENSP00000620895
resolver
ensp
ENSP00000620896
resolver
enst
ENST00000380520
resolver
enst
ENST00000380524
resolver
enst
ENST00000380529
resolver
enst
ENST00000380539
resolver
enst
ENST00000380546
resolver
enst
ENST00000612421
resolver
enst
ENST00000616722
resolver
enst
ENST00000642543
resolver
enst
ENST00000643098
resolver
enst
ENST00000644178
resolver
enst
ENST00000644388
resolver
enst
ENST00000645580
resolver
enst
ENST00000860477
resolver
enst
ENST00000860478
resolver
enst
ENST00000860480
resolver
enst
ENST00000860481
resolver
enst
ENST00000860483
resolver
enst
ENST00000860484
resolver
enst
ENST00000860485
resolver
enst
ENST00000860486
resolver
enst
ENST00000860487
resolver
enst
ENST00000860488
resolver
enst
ENST00000860489
resolver
enst
ENST00000860490
resolver
enst
ENST00000860491
resolver
enst
ENST00000860492
resolver
enst
ENST00000860493
resolver
enst
ENST00000860494
resolver
enst
ENST00000860495
resolver
enst
ENST00000860497
resolver
enst
ENST00000860498
resolver
enst
ENST00000860499
resolver
enst
ENST00000860500
resolver
enst
ENST00000860501
resolver
enst
ENST00000860502
resolver
enst
ENST00000860503
resolver
enst
ENST00000860504
resolver
enst
ENST00000860505
resolver
enst
ENST00000860506
resolver
enst
ENST00000860508
resolver
enst
ENST00000860509
resolver
enst
ENST00000860510
resolver
enst
ENST00000860511
resolver
enst
ENST00000860512
resolver
enst
ENST00000860513
resolver
enst
ENST00000860514
resolver
enst
ENST00000860515
resolver
enst
ENST00000922588
resolver
enst
ENST00000922589
resolver
enst
ENST00000922590
resolver
enst
ENST00000950811
resolver
enst
ENST00000950812
resolver
enst
ENST00000950813
resolver
enst
ENST00000950814
resolver
enst
ENST00000950815
resolver
enst
ENST00000950816
resolver
enst
ENST00000950817
resolver
enst
ENST00000950818
resolver
enst
ENST00000950819
resolver
enst
ENST00000950820
resolver
enst
ENST00000950821
resolver
enst
ENST00000950822
resolver
enst
ENST00000950823
resolver
enst
ENST00000950824
resolver
enst
ENST00000950825
resolver
enst
ENST00000950826
resolver
enst
ENST00000950827
resolver
enst
ENST00000950828
resolver
enst
ENST00000950829
resolver
enst
ENST00000950830
resolver
enst
ENST00000950831
resolver
enst
ENST00000950832
resolver
enst
ENST00000950833
resolver
enst
ENST00000950834
resolver
enst
ENST00000950835
resolver
enst
ENST00000950836
resolver
enst
ENST00000950837
resolver
genesymbol
SERPINB6
resolver
genesymbol_syn
PI6
resolver
genesymbol_syn
PTI
resolver
hgnc
HGNC:8950
resolver
uniprot
A0A024QZX5
resolver
uniprot
A0A087X1N8
resolver
uniprot
A0A2R8YD12
resolver
uniprot
B2RBA8
resolver
uniprot
Q59F97
resolver
uniprot
Q5TD06
resolver
uniprot
Q7Z2Y7
resolver
uniprot
Q96J44
resolver
uniprot
Q9UDI7
resolver
uniprot_entry
A0A024QZX5_HUMAN
resolver
uniprot_entry
A0A087X1N8_HUMAN
resolver
uniprot_entry
A0A2R8YD12_HUMAN
resolver
uniprot_entry
SPB6_HUMAN
resolver
uniprot_sec
B2RBA8
resolver
uniprot_sec
Q59F97
resolver
uniprot_sec
Q5TD06
resolver
uniprot_sec
Q7Z2Y7
resolver
uniprot_sec
Q96J44
resolver
uniprot_sec
Q9UDI7
resolver
amino_acid_sequence
MDVLAEANGTFALNLLKTLGKDNSKNVFFSPMSMSCALAMVYMGAKGNTAAQMAQILSFNKSGGGGDIHQGFQSLLTEVNKTGTQYLLRMANRLFGEKSCDFLSSFRDSCQKFYQAEMEELDFISAVEKSRKHINTWVAEKTEGKIAELLSPGSVDPLTRLVLVNAVYFRGNWDEQFDKENTEERLFKVSKNEEKPVQMMFKQSTFKKTYIGEIFTQILVLPYVGKELNMIIMLPDETTDLRTVEKELTYEKFVEWTRLDMMDEEEVEVSLPRFKLEESYDMESVLRNLGMTDAFELGKADFSGMSQTDLSLSKVVHKSFVEVNEEGTEAAAATAAIMMMRCARFVPRFCADHPFLFFIQHSKTNGILFCGRFSSP
uniprot
proteins
disease_involvement
DISEASE: Deafness, autosomal recessive, 91 (DFNB91) [MIM:613453]: A form of non-syndromic deafness characterized by progressive and age-dependent sensorineural hearing loss. Vestibular function is normal. {ECO:0000269|PubMed:20451170}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: May be involved in the regulation of serine proteinases present in the brain or extravasated from the blood (By similarity). Inhibitor of cathepsin G, kallikrein-8 and thrombin. May play an important role in the inner ear in the protection against leakage of lysosomal content during stress and loss of this protection results in cell death and sensorineural hearing loss. {ECO:0000250, ECO:0000269|PubMed:10068683, ECO:0000269|PubMed:17761692, ECO:0000269|PubMed:20451170, ECO:0000269|PubMed:8136380, ECO:0000269|PubMed:8415716}.
uniprot
proteins
mass_dalton
42622
uniprot
proteins
protein_family
Ov-serpin subfamily
uniprot
proteins
protein_family
Serpin family
uniprot
proteins
pubmed
10068683
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14670919
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17761692
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20451170
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8136380
uniprot
proteins
pubmed
8415716
uniprot
proteins
pubmed
8486644
uniprot
proteins
sequence_length
376
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14670919, ECO:0000269|PubMed:17761692, ECO:0000269|PubMed:20451170, ECO:0000269|PubMed:8486644}.
uniprot
proteins