Micu3
entrez
78506
canonical
uniprot
Q9CTY5
canonical
ensembl
ENSMUSG00000039478
resolver
ensp
ENSMUSP00000070241
resolver
ensp
ENSMUSP00000218080
resolver
enst
ENSMUST00000068999
resolver
genesymbol
Micu3
resolver
genesymbol_syn
Efha2
resolver
uniprot_entry
MICU3_MOUSE
resolver
amino_acid_sequence
MAALRRFLWPPPRLSPALAPQQPFLSPWGRPAGTAPGMSGRPFSCREEDEGAVAEAAWRRRRWGELSIAAAAGGGLVGLVCYQLYGDPRADPSELAAPELEDPPRGRGLLPIPVAAAKETVATGRAITEDLDLYATSRERRFRLFASIECEGQLFMTPYDFILAVTTDEPKFAKTWKSLSKQELSQMLSETPPVWKGSSKLFRNLKERGVISYTEYLFLLCILTKPHAGFRIAFNMFDTDGNEMVDKKEFLVLQEIFRKKNEKRETKGDEEKRAMLRLQLYGYHSPTNSVLKTDAGELVSRSYWDTLRRSTSQALFSDLAERADDITSLVADTTLLVHFFGKKGKAELNFEDFYRFMDNLQTEVLEIEFLSYSNGMNTISEEDFAHILLRYTNVENTSVFLENVRYSISEEKGITFDEFRSFFQFLNNLEDFAIALNMYNFASRSIGQDEFKRAVYVATGLKLSPHLVNTVFKIFDVDKDDQLSYKEFIGIMKDRLHRGFRGYKTVQKYPTFKSCLKKELHSR
uniprot
proteins
function
FUNCTION: Tissue-specific calcium sensor of the mitochondrial calcium uniporter (MCU) channel, which specifically regulates MCU channel activity in the central nervous system and skeletal muscle (PubMed:38018177). Senses calcium level via its EF-hand domains: compared to MICU1 and MICU2, MICU3 has a higher affinity for calcium (By similarity). MICU1 and MICU3 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium (By similarity). At low calcium levels, MICU1 occludes the pore of the MCU channel, preventing mitochondrial calcium uptake (By similarity). At higher calcium levels, calcium-binding to MICU1 and MICU3 induces a conformational change that weakens MCU-MICU1 interactions and moves the MICU1-MICU3 heterodimer away from the pore, allowing calcium permeation through the MCU channel (By similarity). The high calcium affinity of MICU3 lowers the calcium threshold necessary for calcium permeation through the MCU channel (By similarity). The MICU1-MICU3 heterodimer promotes flexibility of neurotransmission in neuronal cells by enhancing mitochondrial calcium uptake in presynapses (By similarity). It is also required to increase mitochondrial calcium uptake in skeletal muscle cells, thereby increasing ATP production (PubMed:34845191, PubMed:38018177). {ECO:0000250|UniProtKB:Q86XE3, ECO:0000269|PubMed:34845191, ECO:0000269|PubMed:38018177}.
uniprot
proteins
mass_dalton
59810
uniprot
proteins
protein_family
MICU1 family
uniprot
proteins
protein_family
MICU3 subfamily
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18614015
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23409044
uniprot
proteins
pubmed
34845191
uniprot
proteins
pubmed
38018177
uniprot
proteins
sequence_length
523
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion intermembrane space {ECO:0000305|PubMed:18614015}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q8IYU8}. Note=Recruited to the mitochondrial inner membrane via its association with the uniplex complex. {ECO:0000250|UniProtKB:Q8IYU8}.
uniprot
proteins