Rgs20
entrez
58175
canonical
uniprot
Q9QZB1
canonical
ensembl
ENSMUSG00000002459
resolver
ensp
ENSMUSP00000002533
resolver
ensp
ENSMUSP00000113324
resolver
ensp
ENSMUSP00000113398
resolver
enst
ENSMUST00000002533
resolver
enst
ENSMUST00000118000
resolver
enst
ENSMUST00000119256
resolver
genesymbol
Rgs20
resolver
genesymbol_syn
Rgsz1
resolver
uniprot
E9Q720
resolver
uniprot
F7CHU0
resolver
uniprot
Q14A97
resolver
uniprot
Q3TY63
resolver
uniprot
Q8C5J7
resolver
uniprot
Q9CUV8
resolver
uniprot
Q9QZB2
resolver
uniprot_entry
E9Q720_MOUSE
resolver
uniprot_entry
F7CHU0_MOUSE
resolver
uniprot_entry
Q8C5J7_MOUSE
resolver
uniprot_entry
RGS20_MOUSE
resolver
uniprot_sec
Q14A97
resolver
uniprot_sec
Q3TY63
resolver
uniprot_sec
Q9CUV8
resolver
uniprot_sec
Q9QZB2
resolver
amino_acid_sequence
MRTANGGPRARASPSASPADPGLPEGSERTEMRMRQMCGGSETQGPAPSQQGGRGSNACCFCWCCCCTCSCLTVRNQEDQRPQRASHEIRTDIPACEESPTPTLEEVCAWAQSFDNLMVTPAGRNAFREFLRTEFSEENMLFWMACEELKREANKSTIEEKARIIYEDYISILSPKEVSLDSRVREVINRNMVDPSQHIFDDAQLQIYTLMHRDSYPRFMNSTVYKDLLTSLAEKTVEA
uniprot
proteins
function
FUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds selectively to G(z)-alpha and G(alpha)-i2 subunits, accelerates their GTPase activity and regulates their signaling activities. The G(z)-alpha activity is inhibited by the phosphorylation and palmitoylation of the G protein. Negatively regulates mu-opioid receptor-mediated activation of the G proteins. {ECO:0000269|PubMed:14997173, ECO:0000269|PubMed:15827571, ECO:0000269|PubMed:16900103}.
uniprot
proteins
mass_dalton
26986
uniprot
proteins
post_translational_modification
PTM: Fatty acylated. Heavily palmitoylated in the cysteine string motif (By similarity). {ECO:0000250}.; PTM: N- and O-glycosylated in synapsomal membranes. {ECO:0000269|PubMed:14997173}.; PTM: Serine phosphorylated in synapsomal membranes. {ECO:0000269|PubMed:16900103}.; PTM: Sumoylated with SUMO1, SUMO2 and SUMO3. Sumoylation increases binding to the G proteins, G(alpha)-i2 and G(z), and interaction with mu-opioid receptors. {ECO:0000269|PubMed:16900103}.
uniprot
proteins
pubmed
14997173
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15827571
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16900103
uniprot
proteins
sequence_length
239
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Lipid-anchor. Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm/cell membrane and the nucleus Anchored to the membrane through palmitoylation. {ECO:0000250}.
uniprot
proteins