Mstn
entrez
17700
canonical
uniprot
O08689
canonical
ensembl
ENSMUSG00000026100
resolver
ensp
ENSMUSP00000027269
resolver
enst
ENSMUST00000027269
resolver
genesymbol
Mstn
resolver
genesymbol_syn
Gdf8
resolver
uniprot
Q540E2
resolver
uniprot_entry
GDF8_MOUSE
resolver
uniprot_entry
Q540E2_MOUSE
resolver
amino_acid_sequence
MMQKLQMYVYIYLFMLIAAGPVDLNEGSEREENVEKEGLCNACAWRQNTRYSRIEAIKIQILSKLRLETAPNISKDAIRQLLPRAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIITMPTESDFLMQADGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVKTPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMSPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS
uniprot
proteins
function
FUNCTION: Acts specifically as a negative regulator of skeletal muscle growth. {ECO:0000269|PubMed:14671324, ECO:0000269|PubMed:24076600, ECO:0000269|PubMed:9139826}.
uniprot
proteins
mass_dalton
42921
uniprot
proteins
mutagenesis
MUTAGEN 99; /note="R->Q: No effect on proteolytic cleavage."; /evidence="ECO:0000269|PubMed:14671324"; MUTAGEN 100; /note="D->A: Blocks proteolytic cleavage; increases muscle mass when injected into adult mice."; /evidence="ECO:0000269|PubMed:14671324
uniprot
proteins
post_translational_modification
PTM: Synthesized as large precursor molecule that undergoes proteolytic cleavage to generate an N-terminal propeptide and a disulfide linked C-terminal dimer, which is the biologically active molecule. The circulating form consists of a latent complex of the C-terminal dimer and other proteins, including its propeptide, which maintain the C-terminal dimer in a latent, inactive state. Ligand activation requires additional cleavage of the prodomain by a tolloid-like metalloproteinase (PubMed:14671324). {ECO:0000269|PubMed:14671324}.
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
12595574
uniprot
proteins
pubmed
14671324
uniprot
proteins
pubmed
19644449
uniprot
proteins
pubmed
22052913
uniprot
proteins
pubmed
24076600
uniprot
proteins
pubmed
9139826
uniprot
proteins
sequence_length
376
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:14671324}.
uniprot
proteins