Kcnq1
entrez
16535
canonical
uniprot
P97414
canonical
ensembl
ENSMUSG00000009545
resolver
ensp
ENSMUSP00000009689
resolver
ensp
ENSMUSP00000139548
resolver
ensp
ENSMUSP00000223521
resolver
ensp
ENSMUSP00000223527
resolver
genesymbol
Kcnq1
resolver
genesymbol_syn
Kcna9
resolver
genesymbol_syn
Kvlqt1
resolver
uniprot
O88702
resolver
uniprot
Q3U4H1
resolver
uniprot
Q7TNZ1
resolver
uniprot
Q7TPL7
resolver
uniprot
Q80VR7
resolver
uniprot_entry
KCNQ1_MOUSE
resolver
uniprot_sec
O88702
resolver
uniprot_sec
Q3U4H1
resolver
uniprot_sec
Q7TNZ1
resolver
uniprot_sec
Q7TPL7
resolver
uniprot_sec
Q80VR7
resolver
activity_regulation
ACTIVITY REGULATION: PIP2 molecule is essential to activate KCNQ channels by inducing the coupling of the voltage-sensing domain (VSD) and the pore-forming domain (PD). Upon channel activation, PIP2 disrupts the VSD-calmodulin/CALM interactions, causing the release of CALM from the VSD which triggers the opening of the gate. Calcium potentiates KCNQ1 channel current through calcium-bound CALM. Calcium-bound CALM competes with PIP2 to stabilize the channel open state. {ECO:0000250|UniProtKB:P51787}.
uniprot
proteins
amino_acid_sequence
MDTASSPPSAERKRAGWSRLLGARRGSAVVKKCPFSLELAEGGPEGSTVYAPIAPTGAPGLAPPMSTPVSPAPAPADLGPRPRVSLDPRVSIYSARRPLLARTHIQGRVYNFLERPTGWKCFVYHFTVFLIVLVCLIFSVLSTIEQYAALATGTLFWMEIVLVVFFGTEYVVRLWSAGCRSKYVGIWGRLRFARKPISIIDLIVVVASMVVLCVGSKGQVFATSAIRGIRFLQILRMLHVDRQGGTWRLLGSVVFIHRQELITTLYIGFLGLIFSSYFVYLAEKDAVNESGRIEFGSYADALWWGVVTVTTIGYGDKVPQTWVGKTIASCFSVFAISFFALPAGILGSGFALKVQQKQRQKHFNRQIPAAASLIQTAWRCYAAENPDSATWKIYVRKPARSHTLLSPSPKPKKSVMVKKKKFKLDKDNGMSPGEKMFNVPHITYDPPEDRRPDHFSIDGYDSSVRKSPTLLEVSTPHFLRTNSFAEDLDLEGETLLTPITHVSQLRDHHRATIKVIRRMQYFVAKKKFQQARKPYDVRDVIEQYSQGHLNLMVRIKELQRRLDQSIGKPSLFIPISEKSKDRGSNTIGARLNRVEDKVTQLDQRLVIITDMLHQLLSMQQGGPTCNSRSQVVASNEGGSINPELFLPSNSLPTYEQLTVPQTGPDEGS
uniprot
proteins
function
FUNCTION: Pore-forming subunit of the voltage-gated potassium (Kv) channel involved in the regulation of cardiomyocyte excitability and important in normal development and functions of myocardium, inner ear, stomach and colon (By similarity) (PubMed:11120752, PubMed:15004216, PubMed:16314573). Associates with KCNE beta subunits that modulates current kinetics (By similarity) (PubMed:15004216, PubMed:17597584). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity) (PubMed:8900282). Also promotes a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks) (By similarity) (PubMed:15004216, PubMed:17597584). Muscarinic agonist oxotremorine-M strongly suppresses KCNQ1/KCNE1 current (By similarity). When associated with KCNE3, forms the potassium channel that is important for cyclic AMP-stimulated intestinal secretion of chloride ions (By similarity). This interaction with KCNE3 is reduced by 17beta-estradiol, resulting in the reduction of currents (By similarity). During conditions of increased substrate load, maintains the driving force for proximal tubular and intestinal sodium ions absorption, gastric acid secretion, and cAMP-induced jejunal chloride ions secretion (PubMed:16314573). Allows the provision of potassium ions to the luminal membrane of the secretory canaliculus in the resting state as well as during stimulated acid secretion (PubMed:19491250). When associated with KCNE2, forms a heterooligomer complex leading to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (By similarity). When associated with KCNE4, inhibits voltage-gated potassium channel activity (By similarity). When associated with KCNE5, this complex only conducts current upon strong and continued depolarization (By similarity). Also forms a heterotetramer with KCNQ5; has a voltage-gated potassium channel activity (By similarity). Binds with phosphatidylinositol 4,5-bisphosphate (By similarity). KCNQ1-KCNE2 channel associates with Na(+)-coupled myo-inositol symporter in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (PubMed:24595108). {ECO:0000250|UniProtKB:P51787, ECO:0000250|UniProtKB:Q9Z0N7, ECO:0000269|PubMed:11120752, ECO:0000269|PubMed:15004216, ECO:0000269|PubMed:16314573, ECO:0000269|PubMed:17597584, ECO:0000269|PubMed:19491250, ECO:0000269|PubMed:24595108, ECO:0000269|PubMed:8900282}.
uniprot
proteins
mass_dalton
74514
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-27 by PKA; increases delayed rectifier potassium channel activity of the KCNQ1-KCNE1 complex through a macromolecular complex that includes PKA, PP1, and the targeting protein AKAP9. {ECO:0000250|UniProtKB:P51787}.; PTM: Ubiquitinated by NEDD4L; promotes internalization. The ubiquitinylated form is internalized through a clathrin-mediated endocytosis by interacting with AP2M1 and is recycled back to the cell membrane via RAB4A and RAB11A. {ECO:0000250|UniProtKB:P51787}.; PTM: Deubiquitinated by USP2; counteracts the NEDD4L-specific down-regulation of I(Ks) and restores the membrane localization. {ECO:0000250|UniProtKB:P51787}.
uniprot
proteins
protein_family
KQT (TC 1.A.1.15) subfamily
uniprot
proteins
protein_family
Kv7.1/KCNQ1 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
11120752
uniprot
proteins
pubmed
15004216
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16314573
uniprot
proteins
pubmed
17597584
uniprot
proteins
pubmed
19491250
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24595108
uniprot
proteins
pubmed
8900282
uniprot
proteins
pubmed
9618174
uniprot
proteins
sequence_length
668
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P51787}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P51787}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P51787}. Early endosome {ECO:0000250|UniProtKB:P51787}. Membrane raft {ECO:0000250|UniProtKB:P51787}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P51787}. Basolateral cell membrane {ECO:0000250|UniProtKB:P51787}. Apical cell membrane {ECO:0000269|PubMed:24595108}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalized with KCNE3 at the plasma membrane. Upon 17beta-oestradiol treatment, colocalizes with RAB5A at early endosome. Heterotetramer with KCNQ5 is highly retained at the endoplasmic reticulum and is localized outside of lipid raft microdomains. During the early stages of epithelial cell polarization induced by the calcium switch it is removed from the plasma membrane to the endoplasmic reticulum, where it is retained, and redistributed to the basolateral cell surface in a PI3K-dependent manner at a later stage. Colocalizes with SLC5A3 at the apical membrane of choroid plexus epithelium (PubMed:24595108). {ECO:0000250|UniProtKB:P51787, ECO:0000269|PubMed:24595108}.
uniprot
proteins
transmembrane_region
TRANSMEM 120..141; /note="Helical; Name=Segment S1"; /evidence="ECO:0000250|UniProtKB:P51787"; TRANSMEM 153..175; /note="Helical; Name=Segment S2"; /evidence="ECO:0000250|UniProtKB:P51787"; TRANSMEM 192..217; /note="Helical; Name=Segment S3"; /evidence="ECO:0000250|UniProtKB:P51787"; TRANSMEM 226..241; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000250|UniProtKB:P51787"; TRANSMEM 260..282; /note="Helical; Name=Segment S5"; /evidence="ECO:0000250|UniProtKB:P51787"; TRANSMEM 322..347; /note="Helical; Name=Segment S6"; /evidence="ECO:0000250|UniProtKB:P51787
uniprot
proteins