Fbxo11
entrez
225055
canonical
uniprot
Q7TPD1
canonical
ensembl
ENSMUSG00000005371
resolver
ensp
ENSMUSP00000005504
resolver
ensp
ENSMUSP00000121206
resolver
ensp
ENSMUSP00000212522
resolver
ensp
ENSMUSP00000212525
resolver
ensp
ENSMUSP00000212526
resolver
genesymbol
Fbxo11
resolver
uniprot
A1A595
resolver
uniprot
E9QP06
resolver
uniprot
Q08EB9
resolver
uniprot
Q08EC0
resolver
uniprot
Q80UP0
resolver
uniprot_entry
FBX11_MOUSE
resolver
uniprot_sec
A1A595
resolver
uniprot_sec
E9QP06
resolver
uniprot_sec
Q08EB9
resolver
uniprot_sec
Q08EC0
resolver
uniprot_sec
Q80UP0
resolver
amino_acid_sequence
MNSVRAANRRPRRVSRPRPVQQQQQQPPQQPPPQPPQQQPPPQPPQQPPQQQPPPPPQQQPPPPPPPPPPPPQDRNNAGERDDVPADMVAEESGPGAQNSPYQLRRKTLLPKRTACPTKSSMEGASTSTTENFGHRAKRARVSGKSQDLSAAPAEQYLQEKLPDEVVLKIFSYLLEQDLCRAACVCKRFSELANDPILWKRLYMEVFEYTRPMMHPEPGKFYQINPEEYEHPNPWKESFQQLYKGAHVKPGFAEHFYSNPARYKGRENMLYYDTIEDALGGVQEAHFDGLIFVHSGIYTDEWIYIESPITMIGAAPGKVADKVIIENTRDSTFVFMEGSEDAYVGYMTIRFNPDDKSAQHHNAHHCLEITVNCSPIIDHCIIRSTCTVGSAVCVSGQGACPTIKHCNISDCENVGLYITDHAQGIYEDNEISNNALAGIWVKNHGNPIIRRNHIHHGRDVGVFTFDHGMGYFESCNIHRNRIAGFEVKAYANPTVVRCEIHHGQTGGIYVHEKGRGQFIENKIYANNFAGVWITSNSDPTIRGNSIFNGNQGGVYIFGDGRGLIEGNDIYGNALAGIQIRTNSCPIVRHNKIHDGQHGGIYVHEKGQGVIEENEVYSNTLAGVWVTTGSTPVLRRNRIHSGKQVGVYFYDNGHGVLEDNDIYNHMYSGVQIRTGSNPKIRRNKIWGGQNGGILVYNSGLGCIEDNEIFDNAMAGVWIKTDSNPTLRRNKIHDGRDGGICIFNGGRGLLEENDIFRNAQAGVLISTNSHPVLRKNRIFDGFAAGIEITNHATATLEGNQIFNNRFGGLFLASGVNVTMKDNKIMNNQDAIEKAVSRGQCLYKISSYTSYPMHDFYRCHTCNTTDRNAICVNCIKKCHQGHDVEFIRHDRFFCDCGAGTLSNPCTLAGEPTHDTDTLYDSAPPIESNTLQHN
uniprot
proteins
function
FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6, SNAI1 and PRDM1/BLIMP1 (PubMed:25827072). The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells (By similarity). The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit (By similarity). The SCF(FBXO11) complex also catalyzes ubiquitination and degradation of GSK3B-phosphorylated SNAI1 (PubMed:25827072). Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity (By similarity). Plays a role in the regulatiom of erythropoiesis but not myelopoiesis or megakaryopoiesis (By similarity). Mechanistically, activates erythroid genes by mediating the degradation of BAHD1, a heterochromatin-associated protein that recruits corepressors to H3K27me3 marks (By similarity). Participates in macrophage cell death and inflammation in response to bacterial toxins by regulating the expression of complement 5a receptor 1/C5AR1 and IL-1beta (By similarity). Acts as a critical regulator to determine the level of MHC-II by mediating the recognition of degron at the P/S/T domain of CIITA leading to its ubiquitination and subsequent degradation via the proteasome (By similarity). Participates in the antiviral repsonse by initiating the activation of TBK1-IRF3-IFN-I axis (By similarity). Mediates the 'Lys-63'-linked ubiquitination of TRAF3 to strengthen the interaction between TRAF3 and TBK1 (By similarity). {ECO:0000250|UniProtKB:Q86XK2, ECO:0000269|PubMed:25827072}.
uniprot
proteins
mass_dalton
103728
uniprot
proteins
mutagenesis
MUTAGEN 331; /note="S->L: In Mutt mutant; 13% of heterozygotes show a reduced startle response to a toneburst of 24 kHz and a mild craniofacial abnormality. 17% of homozygotes show perinatal lethality. Surviving homozygotes demonstrate a marked craniofacial abnormality and reduced hearing."; /evidence="ECO:0000269|PubMed:17035249"; MUTAGEN 578; /note="Q->L: In Jeff mutant; heterozygotes are deaf with chronic proliferative otitis media, have a shortened snout and occipital region, and are smaller than wild-type littermates. Homozygotes demonstrate perinatal lethality due to respiratory problems, are born with upper eyelids open and show clefting of the hard or soft palate as well as facial clefting."; /evidence="ECO:0000269|PubMed:12943368, ECO:0000269|PubMed:17035249
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:25827072}.
uniprot
proteins
pubmed
12943368
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17035249
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
25827072
uniprot
proteins
sequence_length
930
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q86XK2}. Chromosome {ECO:0000250|UniProtKB:Q86XK2}.
uniprot
proteins