Fas
entrez
246097
canonical
uniprot
Q63199
canonical
ensembl
ENSRNOG00000019142
resolver
ensp
ENSRNOP00000025928
resolver
enst
ENSRNOT00000025928
resolver
genesymbol
Fas
resolver
genesymbol_syn
Apt1
resolver
genesymbol_syn
Tnfrsf6
resolver
uniprot
F1LWQ2
resolver
uniprot_entry
F1LWQ2_RAT
resolver
uniprot_entry
TNR6_RAT
resolver
amino_acid_sequence
MLWIMAVLPLVLAGPELNVRMQGTDSIFEGLELKRSVRETDNNCSEGLYQVGPFCCQPCQPGERKVKDCTTSGGAPTCHPCTEGEEYTDRKHYSDKCRRCAFCDEGHGLEVETNCTRTQNTKCRCKENFYCNASLCDHCYHCTSCGLEDILEPCTRTSNTKCKKQSSNYKLLWLLILPGLAILFVFIYKRYRKRQPGDPESGIPSPESVPMNVSDVNLNKYIWRTAEKMKICDAKKFARQHKIPESKIDEIEHNSPQDAAEQKIQLLQCWYQSHGKTGACQALIQGLRKANRCDIAEEIQAMVWEDHENSISNSRNENEGQSLE
uniprot
proteins
function
FUNCTION: Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity). {ECO:0000250|UniProtKB:P25445}.
uniprot
proteins
mass_dalton
36835
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. Palmitoylation by ZDHHC7 prevents the lysosomal degradation of FAS regulating its expression at the plasma membrane. {ECO:0000250|UniProtKB:P25445}.
uniprot
proteins
pubmed
15383280
uniprot
proteins
pubmed
7507668
uniprot
proteins
sequence_length
324
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P51867}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P51867}. Membrane raft {ECO:0000250|UniProtKB:P25445}.
uniprot
proteins
transmembrane_region
TRANSMEM 172..188; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins