Sst
entrez
20604
canonical
uniprot
P60041
canonical
ensembl
ENSMUSG00000004366
resolver
ensp
ENSMUSP00000004480
resolver
ensp
ENSMUSP00000290013
resolver
enst
ENSMUST00000004480
resolver
genesymbol
Sst
resolver
genesymbol_syn
Smst
resolver
uniprot
P01167
resolver
uniprot
Q545V6
resolver
uniprot_entry
Q545V6_MOUSE
resolver
uniprot_entry
SMS_MOUSE
resolver
uniprot_sec
P01167
resolver
amino_acid_sequence
MLSCRLQCALAALCIVLALGGVTGAPSDPRLRQFLQKSLAAATGKQELAKYFLAELLSEPNQTENDALEPEDLPQAAEQDEMRLELQRSANSNPAMAPRERKAGCKNFFWKTFTSC
uniprot
proteins
function
FUNCTION: [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH-stimulated secretion of GH1 and LH; the inhibition of ghrelin-stimulated secretion of GH1 can be further increased by neuronostatin. {ECO:0000250|UniProtKB:P61278}.; FUNCTION: [Neuronostatin]: May enhance low-glucose-induced glucagon release by pancreatic alpha cells (PubMed:24735892). This effect may be mediated by binding to GPR107 and PKA activation (PubMed:26561648). May regulate cardiac contractile function (PubMed:25012062). May compromise cardiomyocyte viability (By similarity). In the central nervous system, may impair memory retention and may affect hippocampal excitability (By similarity). May also have anxiolytic and anorexigenic effects (By similarity). May play a role in arterial pressure regulation (By similarity). May inhibit basal, but not ghrelin- or GnRH-stimulated secretion of GH1 or LH, but does not affect the release of other pituitary hormones, including PRL, ACTH, FSH or TSH (By similarity). Potentiates inhibitory action of somatostatin on ghrelin-stimulated secretion of GH1, but not that on GnRH-stimulated secretion of LH (By similarity). {ECO:0000250|UniProtKB:P60042, ECO:0000250|UniProtKB:P61278, ECO:0000269|PubMed:24735892, ECO:0000269|PubMed:25012062, ECO:0000269|PubMed:26561648}.
uniprot
proteins
mass_dalton
12746
uniprot
proteins
post_translational_modification
PTM: C-terminal amidation of the neuronostatin peptide is required for its biological activity, including for the regulation of mean arterial pressure. {ECO:0000250|UniProtKB:P60042}.
uniprot
proteins
protein_family
Somatostatin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18753129
uniprot
proteins
pubmed
1969620
uniprot
proteins
pubmed
24735892
uniprot
proteins
pubmed
25012062
uniprot
proteins
pubmed
26561648
uniprot
proteins
sequence_length
116
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P60042}.
uniprot
proteins