Fahd1
entrez
302980
canonical
uniprot
Q6AYQ8
canonical
ensembl
ENSRNOG00000014727
resolver
ensembl
ENSRNOG00055028863
resolver
ensembl
ENSRNOG00060010672
resolver
ensembl
ENSRNOG00065010903
resolver
ensp
ENSRNOP00000019767
resolver
ensp
ENSRNOP00055041149
resolver
ensp
ENSRNOP00060014088
resolver
ensp
ENSRNOP00065013566
resolver
enst
ENSRNOT00000019767
resolver
enst
ENSRNOT00055049971
resolver
enst
ENSRNOT00060018083
resolver
enst
ENSRNOT00065017677
resolver
genesymbol
Fahd1
resolver
uniprot_entry
FAHD1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Oxaloacetate decarboxylation is competitively inhibited by oxalate. {ECO:0000250|UniProtKB:Q8R0F8}.
uniprot
proteins
amino_acid_sequence
MASTKPLSRFWEWGKNIVCVGRNYADHVKEMRSTVLSEPVLFLKPSTAYAPEGSPVLMPAYCRNLHHEVELGVLLGRRGEAVPEAAAMDYVAGYALCLDMTARDVQDECKKKGLPWTLAKSFTSSCPVSAFVPKEKIPDPHALRLWLKVNGELRQEGKTSSMIFSIPYIISYVSKIITLEEGDLILTGTPKGVGAVKENDEIEAGIDGVVSMRFKVERSKY
uniprot
proteins
ec_number
3.7.1.5
uniprot
proteins
ec_number
4.1.1.112
uniprot
proteins
ec_number
5.3.2.2
uniprot
proteins
function
FUNCTION: Tautomerase that converts enol-oxaloacetate, a strong inhibitor of succinate dehydrogenase, to the physiological keto form of oxaloacetate. It is thereby required to maximize aerobic respiration efficiency by preventing succinate dehydrogenase inhibition. Also acts as a weak oxaloacetate decarboxylase (ODx), catalyzing the decarboxylation of oxaloacetate (OAA) to pyruvate and CO(2), and as such is likely a regulatory enzyme in the TCA cycle. Also displays acylpyruvase activity, being able to hydrolyze acetylpyruvate and fumarylpyruvate in vitro. {ECO:0000250|UniProtKB:Q6P587}.
uniprot
proteins
mass_dalton
24480
uniprot
proteins
protein_family
FAH family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
221
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q6P587}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q6P587}.
uniprot
proteins