Memo1
entrez
298787
canonical
uniprot
Q4QQR9
canonical
ensembl
ENSRNOG00000006340
resolver
ensp
ENSRNOP00000008687
resolver
ensp
ENSRNOP00000080510
resolver
enst
ENSRNOT00000008687
resolver
genesymbol
Memo1
resolver
uniprot_entry
MEMO1_RAT
resolver
amino_acid_sequence
MSNRVVCREASHAGSWYTASGPQLNAQLEGWLSQVQSTKRPARAIIAPHAGYTYCGSCAAHAYKQVDPSITRRIFILGPSHHVPLSRCALSSVDIYRTPLYDLRIDQKIYGELWKTGMFERMSLQTDEDEHSIEMHLPYTAKAMESHKDEFTIIPVLVGALSESKEQEFGKLFSKYLADPSNLFVVSSDFCHWGQRFRYSYYDESQGEIYRSIEHLDKMGMSIIEQLDPVSFSNYLKKYHNTICGRHPIGVLLNAITELQKSGMNMSFSFLNYAQSSQCRSWQDSSVSYAAGALTVH
uniprot
proteins
function
FUNCTION: May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
33679
uniprot
proteins
protein_family
MEMO1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
297
uniprot
proteins