Clk4
entrez
12750
canonical
uniprot
O35493
canonical
ensembl
ENSMUSG00000020385
resolver
ensp
ENSMUSP00000090820
resolver
ensp
ENSMUSP00000104741
resolver
genesymbol
Clk4
resolver
uniprot
O35721
resolver
uniprot
Q4FJV9
resolver
uniprot
Q8CEU9
resolver
uniprot
Q99LU6
resolver
uniprot_entry
CLK4_MOUSE
resolver
uniprot_entry
Q4FJV9_MOUSE
resolver
uniprot_sec
O35721
resolver
uniprot_sec
Q8CEU9
resolver
uniprot_sec
Q99LU6
resolver
activity_regulation
ACTIVITY REGULATION: TG003 inhibits its kinase activity and affects the regulation of alternative splicing mediated by phosphorylation of SR proteins. {ECO:0000269|PubMed:15010457}.
uniprot
proteins
amino_acid_sequence
MRHSKRTHCPDWDSRESWGHESYSGSHKRKRRSHSSTQENRHCKPHHQFKDSDCHYLEARCLNERDYRDRRYIDEYRNDYCEGYVPRHYHRDVESTYRIHCSKSSVRSRRSSPKRKRNRPCASHQSHSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGLHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPAHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPARRITLDEALQHPFFDLLKRK
uniprot
proteins
ec_number
2.7.12.1
uniprot
proteins
function
FUNCTION: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. {ECO:0000269|PubMed:11461155, ECO:0000269|PubMed:9307018}.
uniprot
proteins
mass_dalton
57345
uniprot
proteins
mutagenesis
MUTAGEN 189; /note="K->R: Loss of function."; /evidence="ECO:0000269|PubMed:12169693
uniprot
proteins
post_translational_modification
PTM: Autophosphorylates on all three types of residues. {ECO:0000269|PubMed:9307018}.
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Lammer subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11461155
uniprot
proteins
pubmed
12169693
uniprot
proteins
pubmed
15010457
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9307018
uniprot
proteins
pubmed
9339371
uniprot
proteins
sequence_length
481
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9307018}.
uniprot
proteins