Slc4a10
entrez
295645
canonical
uniprot
Q80ZA5
canonical
ensembl
ENSRNOG00000005307
resolver
ensp
ENSRNOP00000007218
resolver
ensp
ENSRNOP00000059915
resolver
ensp
ENSRNOP00000062481
resolver
genesymbol
Slc4a10
resolver
genesymbol_syn
NCBE
resolver
genesymbol_syn
Ncbe
resolver
uniprot
A0A097PID6
resolver
uniprot
A0A0G2JYF0
resolver
uniprot
A0A2L1K0J5
resolver
uniprot
D3ZGB5
resolver
uniprot
D3ZY00
resolver
uniprot
D4ADV4
resolver
uniprot
J7FMV4
resolver
uniprot
J7FPF5
resolver
uniprot
J7FRI2
resolver
uniprot
J7FTX0
resolver
uniprot
Q6PU70
resolver
uniprot
Q6PU71
resolver
uniprot
Q6PU72
resolver
uniprot
Q6PU73
resolver
uniprot
Q6PU74
resolver
uniprot
Q80ZA6
resolver
uniprot
W0NXI0
resolver
uniprot_entry
A0A097PID6_RAT
resolver
uniprot_entry
S4A10_RAT
resolver
uniprot_entry
W0NXI0_RAT
resolver
uniprot_sec
A0A0G2JYF0
resolver
uniprot_sec
A0A2L1K0J5
resolver
uniprot_sec
D3ZGB5
resolver
uniprot_sec
D3ZY00
resolver
uniprot_sec
D4ADV4
resolver
uniprot_sec
J7FMV4
resolver
uniprot_sec
J7FPF5
resolver
uniprot_sec
J7FRI2
resolver
uniprot_sec
J7FTX0
resolver
uniprot_sec
Q6PU70
resolver
uniprot_sec
Q6PU71
resolver
uniprot_sec
Q6PU72
resolver
uniprot_sec
Q6PU73
resolver
uniprot_sec
Q6PU74
resolver
uniprot_sec
Q80ZA6
resolver
amino_acid_sequence
MEIKDQGAQMEPLLPTRNDEEAVVDRGGTRSILKTHFEKEDLEGHRTLFIGVHVPLGGRKSHRRHRHRGHKHRKRDRERDSGLEDGGESPSFDTPSQRVQFILGTEDDDEEHIPHDLFTELDEICWREGEDAEWRETARWLKFEEDVEDGGERWSKPYVATLSLHSLFELRSCILNGTVLLDMHANTLEEIADMVLDQQVSSGQLNEDVRHRVHEALMKQHHHQSQKKLTNRIPIVRSFADIGKKQSEPNSMDKNGQVVSPQSAPACAENKNDVSRENSTVDFSKGLGGQQKGHTSPCGMKQRLDKGPPHQQEREVDLHFMKKIPPGAEASNILVGELEFLDRTVVAFVRLSPAVLLQGLAEVPIPSRFLFILLGPLGKGQQYHEIGRSIATLMTDEVFHDVAYKAKDRNDLVSGIDEFLDQVTVLPPGEWDPSIRIEPPKNVPSQEKRKTPSLPNGTAAHGGPEQHGGHSGPELQRTGRIFGGLILDIKRKAPFFWSDFRDAFSLQCLASFLFLYCACMSPVITFGGLLGEATEGRISAIESLFGASMTGIAYSLFGGQPLTILGSTGPVLVFEKILFKFCKEYGLSYLSLRASIGLWTATLCIILVATDASSLVCYITRFTEEAFASLICIIFIYEALEKLFELSESYPINMHNDLELLTQYSCNCMEPHSPSNDTLKEWRESNISASDIIWGNLTVSECRSLHGEYVGRACGHGHPYVPDVLFWSVILFFSTVTMSATLKQFKTSRYFPTKVRSIVSDFAVFLTILCMVLIDYAIGIPSPKLQVPSVFKPTRDDRGWFVTPLGPNPWWTIIAAIIPALLCTILIFMDQQITAVIINRKEHKLKKGCGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSITHVNSLKLESECSAPGEQPKFLGIREQRVTGLMIFILMGSSVFMTSILKFIPMPVLYGVFLYMGASSLKGIQLFDRIKLFWMPAKHQPDFIYLRHVPLRKVHLFTVIQMSCLGLLWIIKVSRAAIVFPMMVLALVFVRKLMDFLFTKRELSWLDDLMPESKKKKLEDAEKEEEQSMLAMEDEGTVQLPLEGHYRDDPSVINISDEMSKTAMWGNLLVTADNSKEKESRFPSKSSPS
uniprot
proteins
function
FUNCTION: Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH (PubMed:20566632, PubMed:23409100). Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (PubMed:10993873, PubMed:20566632). Has also been shown to act as a sodium/biocarbonate cotransporter which does not couple net influx of bicarbonate to net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange (By similarity). Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid (By similarity). Acting on presynaptic intracellular pH, it promotes GABA release, reduces the excitability of CA1 pyramidal neurons, and modulates short-term synaptic plasticity (By similarity). Required in retinal cells to maintain normal pH which is necessary for normal vision (By similarity). In the kidney, likely to mediate bicarbonate reclamation in the apical membrane of the proximal tubules (PubMed:28280139). {ECO:0000250|UniProtKB:Q5DTL9, ECO:0000250|UniProtKB:Q6U841, ECO:0000269|PubMed:20566632, ECO:0000269|PubMed:23409100, ECO:0000269|PubMed:28280139}.; FUNCTION: [Isoform 12]: Sodium/bicarbonate cotransporter which mediates cotransport of sodium and bicarbonate in association with an efflux of intracellular chloride and is involved in NaCl absorption in the small intestine. {ECO:0000269|PubMed:31736772}.
uniprot
proteins
mass_dalton
125639
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q5DTL9}.
uniprot
proteins
protein_family
Anion exchanger (TC 2.A.31) family
uniprot
proteins
pubmed
10993873
uniprot
proteins
pubmed
14592810
uniprot
proteins
pubmed
14656289
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
18061361
uniprot
proteins
pubmed
20566632
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23409100
uniprot
proteins
pubmed
24223558
uniprot
proteins
pubmed
28280139
uniprot
proteins
pubmed
31736772
uniprot
proteins
sequence_length
1117
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:14592810, ECO:0000269|PubMed:18061361, ECO:0000269|PubMed:28280139}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:28280139}; Multi-pass membrane protein {ECO:0000255}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q5DTL9}. Cell projection, axon {ECO:0000250|UniProtKB:Q5DTL9}. Perikaryon {ECO:0000250|UniProtKB:Q5DTL9}. Presynapse {ECO:0000250|UniProtKB:Q5DTL9}. Postsynapse {ECO:0000250|UniProtKB:Q5DTL9}. Note=Detected in dendrites and axon terminals of retinal OFF bipolar cells and in axon terminals of ON bipolar cells. In amacrine cells, located in the perikaryon. Also detected in basal and apical dendrites of hippocampal pyramidal cells (By similarity). Localized to GABAergic inhibitory presynapses (By similarity). In the kidney, isoforms starting with Met-Glu-Ile-Lys localize predominantly to the basolateral membrane of renal thick ascending limbs and inner medullary collecting ducts while isoforms starting with Met-Cys-Asp-Leu localize to the apical membrane of proximal tubules (PubMed:28280139). {ECO:0000250|UniProtKB:Q5DTL9, ECO:0000269|PubMed:28280139}.; SUBCELLULAR LOCATION: [Isoform 12]: Apical cell membrane {ECO:0000269|PubMed:31736772}; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 509..529; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 538..558; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 562..582; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 596..616; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 626..646; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 720..740; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 762..782; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 809..829; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 855..875; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 912..932; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 935..955; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 998..1018; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins