ALB
entrez
213
canonical
uniprot
P02768
canonical
ensembl
ENSG00000163631
resolver
ensp
ENSP00000295897
resolver
genesymbol
ALB
resolver
hgnc
HGNC:399
resolver
uniprot
E7ESS9
resolver
uniprot
O95574
resolver
uniprot
P04277
resolver
uniprot
Q13140
resolver
uniprot
Q645G4
resolver
uniprot
Q68DN5
resolver
uniprot
Q6UXK4
resolver
uniprot
Q86YG0
resolver
uniprot
Q8IUK7
resolver
uniprot
Q9P157
resolver
uniprot
Q9P1I7
resolver
uniprot
Q9UHS3
resolver
uniprot
Q9UJZ0
resolver
uniprot_entry
ALBU_HUMAN
resolver
uniprot_sec
E7ESS9
resolver
uniprot_sec
O95574
resolver
uniprot_sec
P04277
resolver
uniprot_sec
Q13140
resolver
uniprot_sec
Q645G4
resolver
uniprot_sec
Q68DN5
resolver
uniprot_sec
Q6UXK4
resolver
uniprot_sec
Q86YG0
resolver
uniprot_sec
Q8IUK7
resolver
uniprot_sec
Q9P157
resolver
uniprot_sec
Q9P1I7
resolver
uniprot_sec
Q9UHS3
resolver
uniprot_sec
Q9UJZ0
resolver
amino_acid_sequence
MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIAFAQYLQQCPFEDHVKLVNEVTEFAKTCVADESAENCDKSLHTLFGDKLCTVATLRETYGEMADCCAKQEPERNECFLQHKDDNPNLPRLVRPEVDVMCTAFHDNEETFLKKYLYEIARRHPYFYAPELLFFAKRYKAAFTECCQAADKAACLLPKLDELRDEGKASSAKQRLKCASLQKFGERAFKAWAVARLSQRFPKAEFAEVSKLVTDLTKVHTECCHGDLLECADDRADLAKYICENQDSISSKLKECCEKPLLEKSHCIAEVENDEMPADLPSLAADFVESKDVCKNYAEAKDVFLGMFLYEYARRHPDYSVVLLLRLAKTYETTLEKCCAAADPHECYAKVFDEFKPLVEEPQNLIKQNCELFEQLGEYKFQNALLVRYTKKVPQVSTPTLVEVSRNLGKVGSKCCKHPEAKRMPCAEDYLSVVLNQLCVLHEKTPVSDRVTKCCTESLVNRRPCFSALEVDETYVPKEFNAETFTFHADICTLSEKERQIKKQTALVELVKHKPKATKEQLKAVMDDFAAFVEKCCKADDKETCFAEEGKKLVAASQAALGL
uniprot
proteins
disease_involvement
DISEASE: Hyperthyroxinemia, familial dysalbuminemic (FDAH) [MIM:615999]: A disorder characterized by abnormally elevated levels of total serum thyroxine (T4) in euthyroid patients. It is due to abnormal serum albumin that binds T4 with enhanced affinity. {ECO:0000269|PubMed:7852505, ECO:0000269|PubMed:8048949, ECO:0000269|PubMed:9329347, ECO:0000269|PubMed:9589637}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Analbuminemia (ANALBA) [MIM:616000]: A rare autosomal recessive disorder manifested by the presence of a very low amount of circulating serum albumin. Affected individuals manifest mild edema, hypotension, fatigue, and, occasionally, lower body lipodystrophy (mainly in adult females). The most common biochemical finding is hyperlipidemia, with a significant increase in the total and LDL cholesterol concentrations, but normal concentrations of HDL cholesterol and triglycerides. {ECO:0000269|PubMed:8134387}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs (Probable). Its main function is the regulation of the colloidal osmotic pressure of blood (Probable). Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (PubMed:19021548). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (By similarity). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner (By similarity). The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood (By similarity). The rank order of affinity is zinc > calcium > magnesium (By similarity). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli (PubMed:6234017). Does not prevent iron uptake by the bacterial siderophore aerobactin (PubMed:6234017). {ECO:0000250|UniProtKB:P02769, ECO:0000269|PubMed:19021548, ECO:0000269|PubMed:6234017, ECO:0000305|PubMed:1630489}.
uniprot
proteins
mass_dalton
69367
uniprot
proteins
mutagenesis
MUTAGEN 91; /note="H->A: Impairs metal binding."; /evidence="ECO:0000269|PubMed:28567254
uniprot
proteins
post_translational_modification
PTM: Kenitra variant is partially O-glycosylated at Thr-620. It has two new disulfide bonds Cys-600 to Cys-602 and Cys-601 to Cys-606.; PTM: Glycated in diabetic patients.; PTM: Phosphorylated by FAM20C in the extracellular medium. {ECO:0000269|PubMed:26091039}.; PTM: Acetylated on Lys-223 by acetylsalicylic acid.
uniprot
proteins
protein_family
ALB/AFP/VDB family
uniprot
proteins
pubmed
10388840
uniprot
proteins
pubmed
10940303
uniprot
proteins
pubmed
11168369
uniprot
proteins
pubmed
11483580
uniprot
proteins
pubmed
11680902
uniprot
proteins
pubmed
11743713
uniprot
proteins
pubmed
1225573
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
1347703
uniprot
proteins
pubmed
15047055
uniprot
proteins
pubmed
1518850
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
1630489
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
1859851
uniprot
proteins
pubmed
19021548
uniprot
proteins
pubmed
1946412
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
2068071
uniprot
proteins
pubmed
2104980
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2247440
uniprot
proteins
pubmed
2374930
uniprot
proteins
pubmed
2404284
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
2419329
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2437111
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26091039
uniprot
proteins
pubmed
2727704
uniprot
proteins
pubmed
2762316
uniprot
proteins
pubmed
28330995
uniprot
proteins
pubmed
28567254
uniprot
proteins
pubmed
2911589
uniprot
proteins
pubmed
3009475
uniprot
proteins
pubmed
3087352
uniprot
proteins
pubmed
3474609
uniprot
proteins
pubmed
3479777
uniprot
proteins
pubmed
3759977
uniprot
proteins
pubmed
3828358
uniprot
proteins
pubmed
6171778
uniprot
proteins
pubmed
6234017
uniprot
proteins
pubmed
6275391
uniprot
proteins
pubmed
656055
uniprot
proteins
pubmed
6706980
uniprot
proteins
pubmed
6853480
uniprot
proteins
pubmed
7852505
uniprot
proteins
pubmed
7895732
uniprot
proteins
pubmed
7902134
uniprot
proteins
pubmed
8022807
uniprot
proteins
pubmed
8048949
uniprot
proteins
pubmed
8134387
uniprot
proteins
pubmed
8347685
uniprot
proteins
pubmed
8513793
uniprot
proteins
pubmed
9183005
uniprot
proteins
pubmed
9329347
uniprot
proteins
pubmed
955075
uniprot
proteins
pubmed
9589637
uniprot
proteins
pubmed
9731778
uniprot
proteins
sequence_length
609
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins