Disc1
entrez
244667
canonical
uniprot
Q811T9
canonical
ensembl
ENSMUSG00000043051
resolver
ensp
ENSMUSP00000095914
resolver
ensp
ENSMUSP00000112410
resolver
ensp
ENSMUSP00000112757
resolver
genesymbol
Disc1
resolver
uniprot
Q7TQ21
resolver
uniprot
Q8CF87
resolver
uniprot
Q8CF88
resolver
uniprot
Q8CHP1
resolver
uniprot
Q8CHP2
resolver
uniprot_entry
DISC1_MOUSE
resolver
uniprot_sec
Q7TQ21
resolver
uniprot_sec
Q8CF87
resolver
uniprot_sec
Q8CF88
resolver
uniprot_sec
Q8CHP1
resolver
uniprot_sec
Q8CHP2
resolver
amino_acid_sequence
MQGGGPRGAPIHSPSHGADSGHGLPPAVAPQRRRLTRRPGYMRSTAGSGIGFLSPAVGMPHPSSAGLTGQQSQHSQSKAGQCGLDPGSHCQASLVGKPFLKSSLVPAVASEGHLHPAQRSMRKRPVHFAVHSKNDSRQSERLTGSFKPGDSGFWQELLSSDSFKSLAPSLDAPWNKGSRGLKTVKPLASPALNGPADIASLPGFQDTFTSSFSFIQLSLGAAGERGEAEGCLPSREAEPLHQRPQEMAAEASSSDRPHGDPRHLWTFSLHAAPGLADLAQVTRSSSRQSECGTVSSSSSDTGFSSQDASSAGGRGDQGGGWADAHGWHTLLREWEPMLQDYLLSNRRQLEVTSLILKLQKCQEKVVEDGDYDTAETLRQRLEELEQEKGRLSWALPSQQPALRSFLGYLAAQIQVALHGATQRAGSDDPEAPLEGQLRTTAQDSLPASITRRDWLIREKQRLQKEIEALQARMSALEAKEKRLSQELEEQEVLLRWPGCDLMALVAQMSPGQLQEVSKALGETLTSANQAPFQVEPPETLRSLRERTKSLNLAVRELTAQVCSGEKLCSSLRRRLSDLDTRLPALLEAKMLALSGSCFSTAKELTEEIWALSSEREGLEMFLGRLLALSSRNSRRLGIVKEDHLRCRQDLALQDAAHKTRMKANTVKCMEVLEGQLSSCRCPLLGRVWKADLETCQLLMQSLQLQEAGSSPHAEDEEQVHSTGEAAQTAALAVPRTPHPEEEKSPLQVLQEWDTHSALSPHCAAGPWKEDSHIVSAEVGEKCEAIGVKLLHLEDQLLGAMYSHDEALFQSLQGELQTVKETLQAMILQLQPTKEAGEASASYPTAGAQETEA
uniprot
proteins
function
FUNCTION: Involved in the regulation of multiple aspects of embryonic and adult neurogenesis (PubMed:17825401, PubMed:19502360, PubMed:31444471). Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus (PubMed:17825401, PubMed:19502360). Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance (PubMed:19303846). Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation (PubMed:19778506). Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A (PubMed:19778506). Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development (PubMed:19502360). Inhibits ATF4 transcription factor activity in neurons by disrupting ATF4 dimerization and DNA-binding (PubMed:31444471). Plays a role, together with PCNT, in the microtubule network formation (By similarity). {ECO:0000250|UniProtKB:Q9NRI5, ECO:0000269|PubMed:17825401, ECO:0000269|PubMed:19303846, ECO:0000269|PubMed:19502360, ECO:0000269|PubMed:19778506, ECO:0000269|PubMed:31444471}.
uniprot
proteins
mass_dalton
92525
uniprot
proteins
mutagenesis
MUTAGEN 822; /note="L->Q: Abolished interaction with ATF4."; /evidence="ECO:0000269|PubMed:31444471
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Ubiquitination with 'Lys-48'-linked polyubiquitin chains leads to its proteasomal degradation. {ECO:0000250|UniProtKB:Q9NRI5}.
uniprot
proteins
pubmed
12504857
uniprot
proteins
pubmed
12506198
uniprot
proteins
pubmed
12573262
uniprot
proteins
pubmed
14962739
uniprot
proteins
pubmed
15797709
uniprot
proteins
pubmed
17825401
uniprot
proteins
pubmed
19303846
uniprot
proteins
pubmed
19502360
uniprot
proteins
pubmed
19778506
uniprot
proteins
pubmed
20956536
uniprot
proteins
pubmed
22072671
uniprot
proteins
pubmed
31444471
uniprot
proteins
sequence_length
852
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14962739}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9NRI5}. Mitochondrion {ECO:0000250|UniProtKB:Q9NRI5}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9NRI5}. Postsynaptic density {ECO:0000269|PubMed:22072671}. Note=Colocalizes with NDEL1 in the perinuclear region and the centrosome (PubMed:14962739). Localizes to punctate cytoplasmic foci which overlap in part with mitochondria. Colocalizes with PCNT at the centrosome (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q9NRI5, ECO:0000269|PubMed:14962739}.
uniprot
proteins