Bub1
entrez
12235
canonical
uniprot
O08901
canonical
ensembl
ENSMUSG00000027379
resolver
ensp
ENSMUSP00000028858
resolver
ensp
ENSMUSP00000314257
resolver
ensp
ENSMUSP00000314258
resolver
ensp
ENSMUSP00001091667
resolver
enst
ENSMUST00000028858
resolver
enst
ENSMUST00020183811
resolver
genesymbol
Bub1
resolver
uniprot
A0A8I4YXJ8
resolver
uniprot
A2APR8
resolver
uniprot
O09007
resolver
uniprot
Q8K1K8
resolver
uniprot_entry
A0A8I4YXJ8_MOUSE
resolver
uniprot_entry
A2APR8_MOUSE
resolver
uniprot_entry
BUB1_MOUSE
resolver
uniprot_entry
Q8K1K8_MOUSE
resolver
uniprot_sec
O09007
resolver
activity_regulation
ACTIVITY REGULATION: Autophosphorylated when the cells enters mitosis. {ECO:0000250|UniProtKB:O43683}.
uniprot
proteins
amino_acid_sequence
MDNLENVFRMFEAHMQSYTGNDPLGEWESFIKWVEENFPDNKEYLMTLLEHLMKEFLHKKNYHNDSRFINYCLKFAEYNSDRHQFFEFLYNQGIGTKSSYIYMSWAGHLEAQGELQHASAIFQTGIHNEAEPKELLQQQYRLFQARLTGIHLPAQATTSEPLHSAQILNQVMMTNSSPEKNSACVPKSQGSECSGVASSTCDEKSNMEQRVIMISKSECSVSSSVAPKPEAQQVMYCKEKLIRGDSEFSFEELRAQKYNQRKKHEQWVSEDRNYMKRKEANAFEEQLLKQKMDELHKKLHQVVELSHKDLPASENRPDVSLVCVGQNTCSQQELRGPSLSSISHQTSESSGEKPQEEPSVPLMVNAVNSTLLFPAANLPALPVPVSGQSLTDSRCVNQSVHEFMPQCGPETKEVCETNKVASINDFHTTPNTSLGMVQGTPCKVQPSPTVHTKEALGFIMDMFQAPTLPDISDDKDEWPSLDQNEDAFEAQFQKNAVSSGDWGVKKIMTLSSAFPIFEDGNKENYGLPQPKNKPLGARTFGERSLSKYSSRSNEMPHTDEFMDDSTVCGIRCNKTLAPSPKSIGDFTSAAQLSSTPFHKFPADLVQIPEDKENVVATQYTHMALDSCKENIVDLSKGRKLGPIQEKISASLPCPSQPATGGLFTQEAVFGLEAFKCTGIDHATVEDLSDANAGLQVECVQTLGNVNAPSFTVENPWDDELILKLLSGLSKPVTSYSNTFEWQSKLPAIKTKTEYQLGSLLVYVNHLLGEGAFAQVFEAIHGDVRNAKSEQKCILKVQRPANSWEFYIGMQLMERLKPEVHHMFIKFYSAHLFKNGSILVGELYSYGTLLNVINLYKNTSEKVMPQALVLTFAIRMLYMVEQVHSCEIIHGDIKPDNFILGHRFLEQADEDLATGLALIDLGQSIDMKLFPKGTVFTGKCETSGFQCPEMLSNKPWNYQIDYFGVAATIYCMLFGSYMKVKNEGGVWKPEGLFRRLPHLDMWEEFFHIMLNIPDCHNLPSLDFLRQNMKKLLEQQYSNKIKTLRNRLIVMLSEYKRSRK
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Required for centromeric enrichment of AUKRB in prometaphase. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Promotes the centromeric localization of TOP2A (By similarity). Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis. Essential during early and later stages of embryonic development. Necessary for postimplantation embryogenesis and proliferation of primary embryonic fibroblasts and plays an important role in spermatogenesis and fertility. {ECO:0000250|UniProtKB:O43683, ECO:0000269|PubMed:17925231, ECO:0000269|PubMed:17938250, ECO:0000269|PubMed:19772675}.
uniprot
proteins
mass_dalton
119563
uniprot
proteins
post_translational_modification
PTM: Upon spindle-assembly checkpoint activation it is hyperphosphorylated and its kinase activity toward CDC20 is stimulated. Phosphorylation at Thr-595 is required for interaction with PLK1, phosphorylation at this site probably creates a binding site for the POLO-box domain of PLK1, thus enhancing the PLK1-BUB1 interaction (By similarity). {ECO:0000250|UniProtKB:O43683}.; PTM: Ubiquitinated and degraded during mitotic exit by APC/C-Cdh1. {ECO:0000250|UniProtKB:O43683}.
uniprot
proteins
protein_family
BUB1 subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Ser/Thr protein kinase family
uniprot
proteins
pubmed
17925231
uniprot
proteins
pubmed
17938250
uniprot
proteins
pubmed
19772675
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9182760
uniprot
proteins
pubmed
9441741
uniprot
proteins
sequence_length
1058
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:O43683}. Note=Nuclear in interphase cells. Accumulates gradually during G1 and S phase of the cell cycle, peaks at G2/M, and drops dramatically after mitosis. Localizes to the outer kinetochore. Kinetochore localization is required for normal mitotic timing and checkpoint response to spindle damage and occurs very early in prophase. AURKB, KNL1 and INCENP are required for kinetochore localization (By similarity). {ECO:0000250|UniProtKB:O43683}.
uniprot
proteins