Gpi
entrez
292804
canonical
uniprot
Q6P6V0
canonical
ensembl
ENSRNOG00000023150
resolver
ensembl
ENSRNOG00055033158
resolver
ensembl
ENSRNOG00060027113
resolver
ensembl
ENSRNOG00065031609
resolver
ensp
ENSRNOP00000029515
resolver
ensp
ENSRNOP00055047244
resolver
ensp
ENSRNOP00060039184
resolver
ensp
ENSRNOP00065044842
resolver
enst
ENSRNOT00000032613
resolver
enst
ENSRNOT00055057309
resolver
enst
ENSRNOT00060047108
resolver
enst
ENSRNOT00065054503
resolver
genesymbol
Gpi
resolver
uniprot_entry
G6PI_RAT
resolver
amino_acid_sequence
MAALTRNPEFQKLLEWHRANSANLKLRELFEADPERFNHFSLNLNTNHGHILLDYSKNLVNKEVLHMLVDLAKSRGVEAARDNMFSGLKINSTEDRAVLHVALRNRSNRSIMMDGKDVMPEVNKVLDKMKSFCQRVRSGDWKGYTGKAITDIINIGIGGSDLGPLMVTEALKPYSKGGPRVWFVSNIDGTHIAKTLANLNPESSLFIIASKTFTTQETITNAETAKEWFLQAAKDPSAVAKHFVALSTNTDKVKEFGIDPKNMFEFWDWVGGRYSLWSAIGLSIALHVGFDHFEQLLSGAHWMDQHFMKTPLDKNAPVLLALLGIWYINFYGCETHAMLPYDQYMHRFAAYFQQGDMESNGKYITKSGARVDYQTGPIVWGEPGTNGQHAFYQLIHQGTKMIPCDFLIPVQTQHPIRNGLHHKILLANFLAQTEALMKGKSPEEARKELQAAGKSPEELEKLLPHKVFEGNRPTNSIVFTKLTPFILGALIAMYEHKIFVQGIIWDINSFDQWGVELGKQLAKKIEPELDGSSAVTSHDSSTNGLIGFIKLQRDTKID
uniprot
proteins
ec_number
5.1.3.-
uniprot
proteins
ec_number
5.3.1.9
uniprot
proteins
function
FUNCTION: Isomerase that catalyzes the conversion of alpha-D-glucose-6-phosphate to beta-D-fructose-6-phosphate, the second step in glycolysis, and the reverse reaction in gluconeogenesis, within the cytoplasm (PubMed:2709006). Also shows C2-epimerase activity, interconverting D-glucose-6-phosphate (G6P) and D-mannose-6-phosphate (M6P) (By similarity). Also displays anomerase activity, interconverting alpha and beta-anomeric forms of G6P, D-fructose-6-phosphate and M6P (By similarity). In addition to its metabolic role, this enzyme functions extracellularly as a cytokine: acts as autocrine motility factor (AMF), a secreted angiogenic factor that enhances endothelial cell motility. Functions as neuroleukin, a neurotrophic factor supporting the survival of spinal and sensory neurons. Released by lectin-stimulated T-cells to induce immunoglobulin secretion (By similarity). {ECO:0000250|UniProtKB:P06744, ECO:0000250|UniProtKB:P12709, ECO:0000250|UniProtKB:Q9N1E2, ECO:0000269|PubMed:2709006}.
uniprot
proteins
mass_dalton
62827
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. {ECO:0000269|PubMed:2709006}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-185 by CK2 has been shown to decrease enzymatic activity and may contribute to secretion by a non-classical secretory pathway. {ECO:0000250|UniProtKB:P06744}.; PTM: ISGylated. {ECO:0000250|UniProtKB:P06744}.
uniprot
proteins
protein_family
GPI family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19343716
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2709006
uniprot
proteins
sequence_length
558
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19343716}. Secreted {ECO:0000250|UniProtKB:P06744}.
uniprot
proteins