Slf1
entrez
105377
canonical
uniprot
Q8R3P9
canonical
ensembl
ENSMUSG00000021597
resolver
ensp
ENSMUSP00000118312
resolver
ensp
ENSMUSP00000236041
resolver
ensp
ENSMUSP00000236042
resolver
ensp
ENSMUSP00000236045
resolver
ensp
ENSMUSP00000236048
resolver
ensp
ENSMUSP00000236049
resolver
ensp
ENSMUSP00000236051
resolver
ensp
ENSMUSP00000236052
resolver
genesymbol
Slf1
resolver
genesymbol_syn
Ankrd32
resolver
genesymbol_syn
Brctd1
resolver
genesymbol_syn
Brctx
resolver
uniprot
Q497V2
resolver
uniprot
Q5XK30
resolver
uniprot
Q8BHY5
resolver
uniprot
Q8BQM6
resolver
uniprot
Q921Y9
resolver
uniprot_entry
SLF1_MOUSE
resolver
uniprot_sec
Q497V2
resolver
uniprot_sec
Q5XK30
resolver
uniprot_sec
Q8BHY5
resolver
uniprot_sec
Q8BQM6
resolver
uniprot_sec
Q921Y9
resolver
amino_acid_sequence
MEDSATKHIIQMTGFKMEEKEALVKLLLKLDCTFIKSEKYKNCTHLIAERLCKSEKFLAACAAGKWVLTKDYIIHSAKSGRWLDETTYEWGYKIEKDSHYSPQMQSAPKRWREELKRTGAPGAFHRWKVVLLVRADKRSDSLVRVLEAGKANVILPKNSPSGITHVIASNARISAEREQENFKAPFYPIQYLGDFLLEKEIQNDEHSQISPAWTKYNNQEKGNDVGFPEMKGAGENMYRTQNKMENHNKNVSDRFVLSEHHKKKFKDFRKDIRSVKKRNTLRRHGLENQKETKKKDKNIQRSYILRKKNKKEGYCKTDDAHDTIRSMLKKRGHYREQKEMKNPLLTDGTKESKTKDVKTNMNLIEIKNALKKQIYKDIYRAQAVRYNCIRVDKQPVYNVEVKNSEFPRGILNLIENLIEGQFFKEAIEELSSLQAHYIPPVCLLHAILENVLQDKIDTFSGRYFHILSALLHLHPPWKSPAMLKYYLELFQCPTCMKGAWDFTEVLIRSCLFNEDFCHQISENISTKVVNLTLLKFFFNLLEGEVRHLSQKLCDWSDSQSLKVTEKAILHEIFWSGSETSGLLTKPVNMLLEWTIYSHKEKCKSNDVFKHELSYLLTGILGAAVDYWIFLGIQMGRNVIRHMSDDLGSYISLSCDDFSSKELEIFICSFSSSWLQMFVAEAIFKKLCLQGPTSTCTEPLSLQKIIDSYLPILGKMDIHGAGKMQSPKKLCQRPCLESQRALLMLNGAKRKQAEGRPELLELNRAKCSSSLKKLKKKSEELSCSKENCPSLVTKMNFHKTNLKGETALHRVCIKNQVEKLIILLSLPGIDINVKDNAGWTPLHEACNYGNTECVQEILQRCPEVDLLTQVDGVTPLHDALSNGHVEIGKLLLQRGGPELLQQRNSKGELPLDYVLSPKDKEELFAITNIDDTVDNFHAKTQKHFYHQQLEFGSFLLSRMLINFCSIFDLSSEFILAFKGLGHLNELLMACNSDTEASNAHTDWLLDVYARNIKTLKKLPSVLKELPENLNVCPGVHTEALLVTLKMMCQSITELS
uniprot
proteins
function
FUNCTION: Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance. The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks. Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions. {ECO:0000250|UniProtKB:Q9BQI6}.
uniprot
proteins
mass_dalton
121004
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15632077
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22036607
uniprot
proteins
sequence_length
1054
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15632077, ECO:0000269|PubMed:22036607}. Cytoplasm {ECO:0000269|PubMed:15632077}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15632077}. Note=Relocalizes with RAD18 to nuclear foci in response to DNA damage (PubMed:22036607). Colocalizes with RAD18 in the nucleus and to centrosomes (PubMed:15632077). Associates with chromatin. Accumulates with RAD18 and the SMC5-SMC6 complex at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner. {ECO:0000250|UniProtKB:Q9BQI6, ECO:0000269|PubMed:15632077, ECO:0000269|PubMed:22036607}.
uniprot
proteins