Grem1
entrez
23892
canonical
uniprot
O70326
canonical
ensembl
ENSMUSG00000074934
resolver
ensp
ENSMUSP00000097170
resolver
enst
ENSMUST00000099575
resolver
genesymbol
Grem1
resolver
genesymbol_syn
Cktsf1b1
resolver
genesymbol_syn
Drm
resolver
uniprot
Q3TNY7
resolver
uniprot_entry
GREM1_MOUSE
resolver
uniprot_entry
Q3TNY7_MOUSE
resolver
amino_acid_sequence
MNRTAYTVGALLLLLGTLLPTAEGKKKGSQGAIPPPDKAQHNDSEQTQSPPQPGSRTRGRGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD
uniprot
proteins
function
FUNCTION: Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as BMP a antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop (PubMed:12808456, PubMed:15201225). Down-regulates the BMP4 signaling in a dose-dependent manner (PubMed:15133038). Antagonist of BMP2; inhibits BMP2-mediated differentiation of osteoblasts (in vitro) (By similarity). Acts as inhibitor of monocyte chemotaxis (By similarity). {ECO:0000250|UniProtKB:O35793, ECO:0000250|UniProtKB:O60565, ECO:0000269|PubMed:12808456, ECO:0000269|PubMed:15133038, ECO:0000269|PubMed:15201225}.
uniprot
proteins
mass_dalton
20710
uniprot
proteins
protein_family
DAN family
uniprot
proteins
pubmed
10965135
uniprot
proteins
pubmed
12808456
uniprot
proteins
pubmed
15133038
uniprot
proteins
pubmed
15201225
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9660951
uniprot
proteins
sequence_length
184
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
uniprot
proteins