PKD1L3
entrez
342372
canonical
uniprot
Q7Z443
canonical
ensembl
ENSG00000277481
resolver
ensp
ENSP00000480090
resolver
enst
ENST00000620267
resolver
genesymbol
PKD1L3
resolver
hgnc
HGNC:21716
resolver
uniprot_entry
PK1L3_HUMAN
resolver
activity_regulation
ACTIVITY REGULATION: The non-selective cation channel is gated following an off-response property by acid: gated open after the removal of acid stimulus, but not during acid application (PubMed:19464260). Regulation of non-selective cation channel activity by external Ca(2+) is bimodal, first sensitizing and subsequently inactivating the current (PubMed:26066678). {ECO:0000269|PubMed:19464260, ECO:0000269|PubMed:26066678}.
uniprot
proteins
amino_acid_sequence
MFFKGGSWLWLYIRTSIILGSELNSPAPHGQNNCYQLNRFQCSFEEAQHYCHVQRGFLAHIWNKEVQDLIRDYLEEGKKWWIGQNVMPLKKHQDNKYPADVAANGPPKPLSCTYLSRNFIRISSKGDKCLLKYYFICQTGDFLDGDAHYERNGNNSHLYQRHKKTKRGVAIARDKMPPGPGHLPTTCHYPLPAHLSKTLCHPISQFPSVLSSITSQVTSAASEPSSQPLPVITQLTMPVSVTHAGQSLAETTSSPKEEGHPNTFTSYLQVSLQKASGQVIDEIAGNFSRAVHGLQALNKLQEACEFLQKLTALTPRFSKPAQVNLINSLIYLSEELLRIPFQNNNSLGFKVPPTVCPFHSLNNVTKAGEGSWLESKRHTEPVEDILEMSLVEFGNIGEAFLEQNQSPESSVTLTSANATLLLSRQNISTLPLSSYTLGHPAPVRLGFPSALALKELLNKHPGVNVQITGLAFNPFKDLDNRNIVGSIGSVLLSANRKLLQVHDLMEDIEIMLWRNVSLETHPTSLNMSTHQLTITVNVTSLEKSLIVSIDPDSPLLMTLYLGFQYQPNCTHFHLNITLPKDKVWQKDEEYTWVLNPEHLQHGIGTYYITAVLSERQEGAQQTPSLVSVITAVTQCYYWEIHNQTWSSAGCQVGPQSTILRTQCLCNHLTFFASDFFVVPRTVNVEDTIKLFLRVTNNPVGVSLLASLLGFYVITVVWARKKDQADMQKVKVTVLADNDPSAQFHYLIQVYTGYRRSAATTAKVVITLYGSEGRSEPHHLCDPQKTVFERGGLDVFLLTTWTSLGNLHSLRLWHDNSGVSPSWYVSQVIVCDMAVKRKWHFLCNCWLAVDLGDCELDRVFIPVSKRELFSFRHLFSSMIVEKFTQDYLWLSIATRHPWNQFTRVQRLSCCMTLLLCNMVINVMFWKINSTTAKRDEQMRPFAVAWSELLVSIHTAVILFPINLVIGRLFPLIEPQETLPLFPPIQASCLSDASVEPLSATMVVEELKETVRFLLRRNTYLLSKCEQPPWSSWDITKLVKLLSSLVSSHLEGQGCHQQGERHWARVVPENHHHFCCYLHRVLQRLKSHLGTLGLTQGHQSCDFLDAASQLQKLQELLETHILPTEQEPSREVTSFAILSSEEGKKPISNGLSKWLTSVCWLLLGFTSLASAFFTALYSLELSKDQATSWMISIILSVLQNIFISQPVKVVFFTFLYSLMMSRMPRLNKENEQQTKRILALLAKCSSSVPGSRDKNNPVYVAPAINSPTKHPERTLKKKKLFKLTGDILVQILFLTLLMTAIYSAKNSNRFYLHQAIWKTFSHQFSEIKLLQDFYPWANHILLPSLYGDYRGKNAVLEPSHCKCGVQLIFQIPRTKTYEKVDEGQLAFCDNGHTCGRPKSLFPGLHLRRFSYICSPRPMVLIPTDELHERLTSKNENGFSYIMRGAFFTSLRLESFTSLQMSKKGCVWSIISQVIYYLLVCYYAFIQGCQLKQQKWRFFTGKRNILDTSIILISFILLGLDMKSISLHKKNMARYRDDQDRFISFYEAVKVNSAATHLVGFPVLLATVQLWNLLRHSPRLRVISRTLSRAWDEVVGFLLIILILLTGYAIAFNLLFGCSISDYRTFFSSAVTVVGLLMGISHQEEVFALDPVLGTFLILTSVILMVLVVINLFVSAILMAFGKERKSLKKEAALIDTLLQKLSNLLGISWPQKTSSEQAATTAVGSDTEVLDELP
uniprot
proteins
function
FUNCTION: Pore-forming subunit of a heterotetrameric, non-selective cation channel that is permeable to Ca(2+) (PubMed:19464260, PubMed:23212381). Also shows permeability towards NA(1+), K(+) and Mg(2+) (PubMed:23212381). Heterotetrameric complex channel is activated by external low pH and Ca(2+), but opens only when the extracellular pH rises again and after the removal of acid stimulus (PubMed:19464260, PubMed:23212381). May act as a sour taste receptor in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect (PubMed:19812697). {ECO:0000269|PubMed:19464260, ECO:0000269|PubMed:19812697, ECO:0000269|PubMed:23212381}.
uniprot
proteins
mass_dalton
195894
uniprot
proteins
post_translational_modification
PTM: Autoproteolytically processed at the GPS region of the GAIN-B domain; this cleavage modulates receptor activity. {ECO:0000255|PROSITE-ProRule:PRU00098}.
uniprot
proteins
protein_family
Polycystin family
uniprot
proteins
pubmed
12782129
uniprot
proteins
pubmed
19464260
uniprot
proteins
pubmed
19812697
uniprot
proteins
pubmed
23212381
uniprot
proteins
pubmed
26066678
uniprot
proteins
sequence_length
1732
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23212381}; Multi-pass membrane protein {ECO:0000255}. Note=Interaction with PKD2L1 is required for localization to the cell membrane. {ECO:0000269|PubMed:23212381}.
uniprot
proteins
transmembrane_region
TRANSMEM 698..718; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 906..926; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 940..960; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1155..1175; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1199..1219; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1290..1300; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q2EG98"; TRANSMEM 1462..1491; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q2EG98"; TRANSMEM 1501..1519; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q2EG98"; TRANSMEM 1551..1572; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q2EG98"; TRANSMEM 1590..1614; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q2EG98"; TRANSMEM 1648..1667; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q2EG98
uniprot
proteins