Plscr3
entrez
360549
canonical
uniprot
Q6QBQ4
canonical
ensembl
ENSRNOG00000027914
resolver
ensembl
ENSRNOG00055029287
resolver
ensembl
ENSRNOG00060031515
resolver
ensembl
ENSRNOG00065029789
resolver
ensp
ENSRNOP00000035566
resolver
ensp
ENSRNOP00055041879
resolver
ensp
ENSRNOP00060045177
resolver
ensp
ENSRNOP00065042426
resolver
enst
ENSRNOT00000031640
resolver
enst
ENSRNOT00055050832
resolver
enst
ENSRNOT00060054640
resolver
enst
ENSRNOT00065051525
resolver
genesymbol
Plscr3
resolver
genesymbol_syn
Pls3
resolver
uniprot
Q4V7A3
resolver
uniprot_entry
PLS3_RAT
resolver
uniprot_sec
Q4V7A3
resolver
amino_acid_sequence
MAGYLPPKGYAPSPPPPYPVPAGYPEAAALHPGPGQAPVPTQGPAPAPGFSLFPSPGPVVPGPPGPFVPLPGVPSGLEFLVQIDQILIHQKAERVETFLGWETCNRYELRSGTGQQLGQAAEESNCCARLCCGARRPLRIRLADPGDREVLRLLRPLHCGCSCCPCGLQEMEVQAPPGTTIGHVLQTWHPFIPKFSILDADRQPVLRVVGPCCTCGCGTDTNFEVKTKDESRSVGRISKQWGGLLREALTDADDFGLQFPVDLDVRVKAVLLGATFLIDYMFFEKRGGAGPSAITS
uniprot
proteins
function
FUNCTION: Catalyzes calcium-induced ATP-independent rapid bidirectional and non-specific movement of the phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer membrane of the mitochondria (PubMed:29171872). Plays an important role in mitochondrial respiratory function, morphology, and apoptotic response (By similarity). Mediates the translocation of cardiolipin from the mitochondrial inner membrane to outer membrane enhancing t-Bid induced cytochrome c release and apoptosis (By similarity). Enhances TNFSF10-induced apoptosis by regulating the distribution of cardiolipin in the mitochondrial membrane resulting in increased release of apoptogenic factors and consequent amplification of the activity of caspases (By similarity). Regulates cardiolipin de novo biosynthesis and its resynthesis (By similarity). {ECO:0000250|UniProtKB:Q9NRY6, ECO:0000269|PubMed:29171872}.
uniprot
proteins
mass_dalton
31646
uniprot
proteins
post_translational_modification
PTM: Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus. {ECO:0000250|UniProtKB:Q9JIZ9}.
uniprot
proteins
protein_family
Phospholipid scramblase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
29171872
uniprot
proteins
sequence_length
296
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:29171872}; Single-pass type II membrane protein {ECO:0000305|PubMed:29171872}. Nucleus {ECO:0000250|UniProtKB:Q9JIZ9}. Note=Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus. {ECO:0000250|UniProtKB:Q9JIZ9}.
uniprot
proteins
transmembrane_region
TRANSMEM 267..283; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins