Acp3
entrez
56780
canonical
uniprot
P20646
canonical
ensembl
ENSRNOG00000011820
resolver
ensembl
ENSRNOG00055012887
resolver
ensembl
ENSRNOG00060008023
resolver
ensembl
ENSRNOG00065007977
resolver
ensp
ENSRNOP00000016222
resolver
ensp
ENSRNOP00000072975
resolver
enst
ENSRNOT00000085585
resolver
genesymbol
Acp3
resolver
genesymbol_syn
Acpp
resolver
uniprot
A0A0G2JSL5
resolver
uniprot
A0A0G2K4B4
resolver
uniprot
A6XJQ5
resolver
uniprot_entry
A0A0G2K4B4_RAT
resolver
uniprot_entry
PPAP_RAT
resolver
uniprot_sec
A0A0G2JSL5
resolver
uniprot_sec
A6XJQ5
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by L(+)-tartrate. {ECO:0000269|PubMed:8077215}.
uniprot
proteins
amino_acid_sequence
MRAVPLHLVGTASLTLGFLLLLSLRLDPGQAKELKFVTLVFRHGDRGPIETFPNDPIKESSWPQGFGQLTKWGMGQHYELGSYIRRRYGRFLNNSYKHDQVYIRSTDVDRTLMSAMTNLAALFPPEGISIWNPRLLWQPIPVHTVSLSEDRLLYLPFRDCPRFQELKSETLKSEEFLKRLQPYKSFIDTLPSLSGFEDQDLFEIWSRLYDPLYCESVHNFTLPTWATEDAMTKLKELSELSLLSLYGIHKQKEKSRLQGGVLVNEILKNMKLATQPQKARKLIMYSAHDTTVSGLQMALDVYNGLLPPYASCHIMELYQDNGGHFVEMYYRNETQNEPYPLTLPGCTHSCPLEKFAELLDPVIPQDWATECMGTSNHQASL
uniprot
proteins
ec_number
3.1.3.2
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
ec_number
3.1.3.5
uniprot
proteins
function
FUNCTION: [Isoform 1]: A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma. {ECO:0000269|PubMed:8077215}.; FUNCTION: [Isoform 2]: In addition to its tyrosine phosphatase activity, also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP. This extracellular adenosine leads to a decrease in chronic pain by activating A1R in nociceptive neurons. {ECO:0000250|UniProtKB:Q8CE08}.
uniprot
proteins
mass_dalton
43739
uniprot
proteins
mutagenesis
MUTAGEN 137; /note="W->E: Abolishes most of enzyme activity and dimer formation. No enzyme activity nor dimer formation; when associated with D-143."; /evidence="ECO:0000269|PubMed:8077215"; MUTAGEN 143; /note="H->D: Abolishes most of enzyme activity and dimer formation. No enzyme activity nor dimer formation; when associated with E-137."; /evidence="ECO:0000269|PubMed:8077215"; MUTAGEN 154; /note="Y->K: PH optimum at 5.4 as for wild type and no change in specific activity. Lower pH maximum around 4.5 and more sensitive to L(+)tartrate inhibition but no change in specific activity; when associated with G-158."; /evidence="ECO:0000269|PubMed:8077215"; MUTAGEN 158; /note="R->G: Broader pH maximum levels around 5.4 but no change in specific activity. Lower pH maximum around 4.5 and more sensitive to L(+)tartrate inhibition but no change in specific activity; when associated with K-154."; /evidence="ECO:0000269|PubMed:8077215"; MUTAGEN 289; /note="D->A,S: Abolishes almost all enzyme activity."; /evidence="ECO:0000269|PubMed:8077215"; MUTAGEN 289; /note="D->N: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:8077215
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:8334986, ECO:0000269|PubMed:8407898}.
uniprot
proteins
protein_family
Histidine acid phosphatase family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
17638863
uniprot
proteins
pubmed
20084276
uniprot
proteins
pubmed
2373368
uniprot
proteins
pubmed
2421214
uniprot
proteins
pubmed
8077215
uniprot
proteins
pubmed
8168503
uniprot
proteins
pubmed
8334986
uniprot
proteins
pubmed
8407898
uniprot
proteins
sequence_length
381
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Secreted {ECO:0000250|UniProtKB:P15309}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000250|UniProtKB:P15309}; Single-pass type I membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:P15309}; Single-pass type I membrane protein {ECO:0000255}. Note=Appears to shuttle between the cell membrane and intracellular vesicles. Colocalizes with FLOT1 at cell membrane and in intracellular vesicles. Colocalizes with LAMP2 on the lysosome membrane. {ECO:0000250|UniProtKB:P15309}.
uniprot
proteins
transmembrane_region
TRANSMEM P20646-2:381..403; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P15309
uniprot
proteins