Penk
entrez
29237
canonical
uniprot
P04094
canonical
ensembl
ENSRNOG00000008943
resolver
ensembl
ENSRNOG00055020056
resolver
ensembl
ENSRNOG00060010280
resolver
ensembl
ENSRNOG00065015561
resolver
ensp
ENSRNOP00000011892
resolver
ensp
ENSRNOP00055027759
resolver
ensp
ENSRNOP00060013494
resolver
ensp
ENSRNOP00065020326
resolver
enst
ENSRNOT00000011892
resolver
enst
ENSRNOT00055034241
resolver
enst
ENSRNOT00060017366
resolver
enst
ENSRNOT00065025840
resolver
genesymbol
Penk
resolver
genesymbol_syn
Penk-rs
resolver
genesymbol_syn
Penk1
resolver
uniprot
Q53X05
resolver
uniprot_entry
PENK_RAT
resolver
uniprot_sec
Q53X05
resolver
amino_acid_sequence
MAQFLRLCIWLLALGSCLLATVQADCSQDCAKCSYRLVRPGDINFLACTLECEGQLPSFKIWETCKDLLQVSKPEFPWDNIDMYKDSSKQDESHLLAKKYGGFMKRYGGFMKKMDELYPVEPEEEANGGEILAKRYGGFMKKDADEGDTLANSSDLLKELLGTGDNRAKDSHQQESTNNDEDSTSKRYGGFMRGLKRSPQLEDEAKELQKRYGGFMRRVGRPEWWMDYQKRYGGFLKRFAESLPSDEEGESYSKEVPEMEKRYGGFMRF
uniprot
proteins
function
FUNCTION: [Met-enkephalin]: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. {ECO:0000250|UniProtKB:P01210}.; FUNCTION: [Leu-enkephalin]: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. {ECO:0000250|UniProtKB:P01210}.; FUNCTION: [Met-enkephalin-Arg-Phe]: Met-enkephalin-Arg-Phe neuropeptide acts as a strong ligand of Mu-type opioid receptor OPRM1 (PubMed:8624732). Met-enkephalin-Arg-Phe-binding to OPRM1 in the nucleus accumbens of the brain increases activation of OPRM1, leading to long-term synaptic depression of glutamate release (By similarity). {ECO:0000250|UniProtKB:P22005, ECO:0000269|PubMed:8624732}.; FUNCTION: [PENK(114-133)]: Increases glutamate release in the striatum and decreases GABA concentration in the striatum. {ECO:0000269|PubMed:19164277}.; FUNCTION: [PENK(239-260)]: Increases glutamate release in the striatum. {ECO:0000269|PubMed:19164277}.; FUNCTION: [Neuropeptide BAM22]: Neuropeptide that mediates stress-induced opioid analgesia (PubMed:17767492, PubMed:6744032, PubMed:7089582). Also possesses non-opioid action by acting as a ligand for MRGPRX1 receptor to induce itch in a histamine-independent manner (By similarity). {ECO:0000250|UniProtKB:P01210, ECO:0000269|PubMed:17767492, ECO:0000269|PubMed:6744032, ECO:0000269|PubMed:7089582}.; FUNCTION: [Neuropeptide BAM8-22]: Neuropeptide that induces itch in a histamine-independent manner as well as nociceptive sensations. Acts as a ligand for MRGPRX1 receptor in sensory neurons of dorsal root ganglion: MRGPRX1-binding in the peripheral nervous system elicits itch and scratching, while MRGPRX1-binding in the central nervous system dampens chronic pain. {ECO:0000250|UniProtKB:P01210}.
uniprot
proteins
mass_dalton
30932
uniprot
proteins
post_translational_modification
PTM: Proenkephalin-A is cleaved by CTSL to generate Met-enkephalin. {ECO:0000250|UniProtKB:P01211}.; PTM: [Met-enkephalin]: Processed and degraded by ACE. {ECO:0000250|UniProtKB:P01210}.; PTM: [Leu-enkephalin]: Processed and degraded by ACE. {ECO:0000250|UniProtKB:P01210}.; PTM: [Met-enkephalin-Arg-Gly-Leu]: Probably cleaved by ACE. {ECO:0000250|UniProtKB:P01210}.; PTM: [Met-enkephalin-Arg-Phe]: Processed by ACE to generate Met-enkephalin in the nucleus accumbens of the brain. {ECO:0000269|PubMed:20487892}.; PTM: The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing. {ECO:0000250|UniProtKB:P01210}.
uniprot
proteins
protein_family
Opioid neuropeptide precursor family
uniprot
proteins
pubmed
1438982
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17767492
uniprot
proteins
pubmed
19164277
uniprot
proteins
pubmed
20487892
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2707437
uniprot
proteins
pubmed
3093884
uniprot
proteins
pubmed
6094550
uniprot
proteins
pubmed
6548748
uniprot
proteins
pubmed
6594709
uniprot
proteins
pubmed
6744032
uniprot
proteins
pubmed
7089582
uniprot
proteins
pubmed
8624732
uniprot
proteins
sequence_length
269
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:19164277}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen {ECO:0000250|UniProtKB:P01211}.
uniprot
proteins