Pth1r
entrez
56813
canonical
uniprot
P25961
canonical
ensembl
ENSRNOG00000020948
resolver
ensembl
ENSRNOG00055007695
resolver
ensembl
ENSRNOG00060020032
resolver
ensembl
ENSRNOG00065004853
resolver
ensp
ENSRNOP00000028435
resolver
ensp
ENSRNOP00000080822
resolver
ensp
ENSRNOP00000094940
resolver
ensp
ENSRNOP00000111934
resolver
ensp
ENSRNOP00055010265
resolver
ensp
ENSRNOP00060028487
resolver
ensp
ENSRNOP00065004870
resolver
enst
ENSRNOT00000028435
resolver
enst
ENSRNOT00000135570
resolver
enst
ENSRNOT00055012880
resolver
enst
ENSRNOT00060034689
resolver
enst
ENSRNOT00065007057
resolver
genesymbol
Pth1r
resolver
genesymbol_syn
Pthr
resolver
genesymbol_syn
Pthr1
resolver
uniprot
A0ABK0M1G5
resolver
uniprot_entry
A0ABK0M1G5_RAT
resolver
uniprot_entry
PTH1R_RAT
resolver
amino_acid_sequence
MGAARIAPSLALLLCCPVLSSAYALVDADDVFTKEEQIFLLHRAQAQCDKLLKEVLHTAANIMESDKGWTPASTSGKPRKEKASGKFYPESKENKDVPTGSRRRGRPCLPEWDNIVCWPLGAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWEVVPGHNRTWANYSECLKFMTNETREREVFDRLGMIYTVGYSMSLASLTVAVLILAYFRRLHCTRNYIHMHMFLSFMLRAASIFVKDAVLYSGFTLDEAERLTEEELHIIAQVPPPPAAAAVGYAGCRVAVTFFLYFLATNYYWILVEGLYLHSLIFMAFFSEKKYLWGFTIFGWGLPAVFVAVWVGVRATLANTGCWDLSSGHKKWIIQVPILASVVLNFILFINIIRVLATKLRETNAGRCDTRQQYRKLLRSTLVLVPLFGVHYTVFMALPYTEVSGTLWQIQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIRKSWSRWTLALDFKRKARSGSSSYSYGPMVSHTSVTNVGPRAGLSLPLSPRLPPATTNGHSQLPGHAKPGAPATETETLPVTMAVPKDDGFLNGSCSGLDEEASGSARPPPLLQEEWETVM
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for parathyroid hormone (PTH) and for parathyroid hormone-related peptide (PTHLH) (PubMed:1313566). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP) (By similarity). PTH1R is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (By similarity). PTHLH dissociates from PTH1R more rapidly than PTH; as consequence, the cAMP response induced by PTHLH decays faster than the response induced by PTH (By similarity). {ECO:0000250|UniProtKB:Q03431, ECO:0000269|PubMed:1313566}.
uniprot
proteins
mass_dalton
66261
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q03431}.; PTM: Phosphorylated on multiple serine residues; these phosphorylations are important for PTH-dependent internalization. {ECO:0000250|UniProtKB:Q03431}.
uniprot
proteins
protein_family
G protein-coupled receptor 2 family
uniprot
proteins
pubmed
1313566
uniprot
proteins
pubmed
8020952
uniprot
proteins
sequence_length
591
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1313566}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 189..212; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 220..239; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 283..306; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 321..342; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 362..382; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 410..428; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 441..463; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins