Prr5
entrez
109270
canonical
uniprot
Q812A5
canonical
ensembl
ENSMUSG00000036106
resolver
ensp
ENSMUSP00000066396
resolver
ensp
ENSMUSP00000127890
resolver
ensp
ENSMUSP00000169160
resolver
genesymbol
Prr5
resolver
genesymbol_syn
Protor1
resolver
uniprot
Q5EAK2
resolver
uniprot
Q8BIE7
resolver
uniprot
Q8BIK1
resolver
uniprot
Q8R1A0
resolver
uniprot_entry
PRR5_MOUSE
resolver
uniprot_sec
Q5EAK2
resolver
uniprot_sec
Q8BIE7
resolver
uniprot_sec
Q8BIK1
resolver
uniprot_sec
Q8R1A0
resolver
amino_acid_sequence
MRTLRRLKFMSSPSLSDLGKREPGAAGTDERGTQQRRACANATWNSIHNGVIAVFQRKGLPDQELFILNEGVRQLLKTELGSFFTEYLQNQLLTKGMVILRDKIRFYEGQKLLDSLAETWDFFFSDVLPTLQAIFYPVQGKEPSVRQLALLHFRNTITLSVKLEDALARSHARVPPAIAQMLLVLQGVHESRGVTEDYLRLETLIQKVVSPYLGTYGLYSNEGPCTHSCILEKRFLRRSRSGDILAKNPVVRSKSYNTPLLNPVAEHEAEGTAASGTSIRRHSVSEMTSCPEPQGFVDTPGQGPSGTFRSSPTPHSGPCPSRLYPPAHSPEQGPGHGSPSTSSPETLVDQILESADSDSEGIFIDFGRGSRSSVSDFEAPGGRPSVV
uniprot
proteins
function
FUNCTION: Associated subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. PRR5 plays an important role in regulation of PDGFRB expression and in modulation of platelet-derived growth factor signaling. May act as a tumor suppressor in breast cancer. {ECO:0000250|UniProtKB:P85299}.
uniprot
proteins
mass_dalton
42523
uniprot
proteins
protein_family
PROTOR family
uniprot
proteins
pubmed
12559566
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15718101
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20801936
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
387
uniprot
proteins