Htr7
entrez
65032
canonical
uniprot
P32305
canonical
ensembl
ENSRNOG00000018827
resolver
ensembl
ENSRNOG00055030434
resolver
ensembl
ENSRNOG00060030044
resolver
ensembl
ENSRNOG00065030344
resolver
ensp
ENSRNOP00000025450
resolver
genesymbol
Htr7
resolver
uniprot
P97936
resolver
uniprot_entry
5HT7R_RAT
resolver
uniprot_sec
P97936
resolver
amino_acid_sequence
MMDVNSSGRPDLYGHLRSLILPEVGRGLQDLSPDGGAHPVVSSWMPHLLSGFLEVTASPAPTWDAPPDNVSGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVQPESVISLNGVVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERSEFVLQNSDHCGKKGHDT
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:8394362, PubMed:8397408, PubMed:8398139). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:8394362). HTR7 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:8394362). {ECO:0000269|PubMed:8394362, ECO:0000269|PubMed:8397408, ECO:0000269|PubMed:8398139}.
uniprot
proteins
mass_dalton
49837
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
8394362
uniprot
proteins
pubmed
8397408
uniprot
proteins
pubmed
8398139
uniprot
proteins
pubmed
8517926
uniprot
proteins
pubmed
9084407
uniprot
proteins
sequence_length
448
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P34969}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P34969}.
uniprot
proteins
transmembrane_region
TRANSMEM 87..111; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P34969"; TRANSMEM 122..143; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P34969"; TRANSMEM 156..181; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P34969"; TRANSMEM 202..222; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P34969"; TRANSMEM 241..263; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P34969"; TRANSMEM 330..355; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P34969"; TRANSMEM 367..390; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P34969
uniprot
proteins