C1qtnf5
entrez
235312
canonical
uniprot
Q8K479
canonical
ensembl
ENSMUSG00000079592
resolver
ensp
ENSMUSP00000110463
resolver
ensp
ENSMUSP00000110464
resolver
ensp
ENSMUSP00000110466
resolver
ensp
ENSMUSP00000110469
resolver
enst
ENSMUST00000114815
resolver
enst
ENSMUST00000114816
resolver
enst
ENSMUST00000114818
resolver
enst
ENSMUST00000114821
resolver
genesymbol
C1qtnf5
resolver
genesymbol_syn
Ctrp5
resolver
uniprot
F8WHS3
resolver
uniprot
Q4ZJN4
resolver
uniprot_entry
C1QT5_MOUSE
resolver
uniprot_entry
Q4ZJN4_MOUSE
resolver
uniprot_sec
F8WHS3
resolver
amino_acid_sequence
MRPLLALLLLGLVSGSPPLDDNKIPSLCPGQPGLPGTPGHHGSQGLPGRDGRDGRDGAPGAPGEKGEGGRPGLPGPRGEPGPRGEAGPMGAIGPAGECSVPPRSAFSAKRSESRVPPPADTPLPFDRVLLNEQGHYDPTTGKFTCQVPGVYYFAVHATVYRASLQFDLVKNGQSIASFFQYFGGWPKPASLSGGAMVRLEPEDQVWVQVGVGDYIGIYASIKTDSTFSGFLVYSDWHSSPVFA
uniprot
proteins
function
FUNCTION: Involved in cellular energy homeostasis through the regulation of 5'-AMP-activated protein kinase (AMPK) phosphorylation and activation. In myocytes, it induces adiponectin receptors-independent AMPK phosphorylation and activation, thereby increasing the phosphorylation of acetyl-CoA carboxylase (ACC) and stimulating fatty acid oxidation and glucose uptake (By similarity). In the retinal pigment epithelium (RPE), it acts as antagonist of adiponectin receptor protein 1 (ADIPOR1) and negatively regulates ADIPOR1-dependent AMPK activation (By similarity). {ECO:0000250|UniProtKB:Q5FVH0, ECO:0000250|UniProtKB:Q9BXJ0}.
uniprot
proteins
mass_dalton
25437
uniprot
proteins
mutagenesis
MUTAGEN 163; /note="S->R: Heterozygous mice develop slower rod-b wave recovery, early dark adaptation abnormalities, accumulation of hyperautofluorescence spots and retinal pigment epithelium anomalies."; /evidence="ECO:0000269|PubMed:21349921
uniprot
proteins
pubmed
12140190
uniprot
proteins
pubmed
17122142
uniprot
proteins
pubmed
17122143
uniprot
proteins
pubmed
21349921
uniprot
proteins
pubmed
22351773
uniprot
proteins
sequence_length
243
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:17122142}. Secreted {ECO:0000250|UniProtKB:Q9BXJ0}. Note=Associated with the lateral and apical membranes of the ocular ciliary body and retinal pigment epithelium. {ECO:0000269|PubMed:17122142}.
uniprot
proteins