Pcsk4
entrez
171085
canonical
uniprot
Q78EH2
canonical
ensembl
ENSRNOG00000016405
resolver
ensp
ENSRNOP00000022358
resolver
genesymbol
Pcsk4
resolver
genesymbol_syn
Nec-3
resolver
genesymbol_syn
Nec3
resolver
uniprot
A1A4C9
resolver
uniprot
Q07213
resolver
uniprot
Q07214
resolver
uniprot_entry
PCSK4_RAT
resolver
uniprot_sec
A1A4C9
resolver
uniprot_sec
Q07213
resolver
uniprot_sec
Q07214
resolver
amino_acid_sequence
MRPSQTALWLGLVLSLALLAVGWASARPPIYVSSWAVRVTKGYQEAERLARKFGFVNLGQIFPDDQYFHLRHRGVAQQSLTPHWGHRLRLKKEPKVRWFEQQTLRRRVKRSLVVPTDPWFSKQWYMNKEIEQDLNILKVWNQGLTGRGVVVSILDDGIEKDHPDLWANYDPLASYDFNDYDPDPQPRYTPNDENRHGTRCAGEVSATANNGFCGAGVAFNARIGGVRMLDGAITDIVEAQSLSLQPQHIHIYSASWGPEDDGRTVDGPGLLTQEAFRRGVTKGRQGLGTLFIWASGNGGLHYDNCNCDGYTNSIHTLSVGSTTRQGRVPWYSEACASTFTTTFSSGVVTDPQIVTTDLHHQCTDKHTGTSASAPLAAGMIALALEANPLLTWRDLQHLVVRASRPAQLQAEDWRINGVGRQVSHHYGYGLLDAGLLVDLARVWLPTKPQKKCTIRVVHTPTPILPRMLVPKNVTVCCDGSRRRLIRSLEHVQVQLSLSYSRRGDLEIFLTSPMGTRSTLVAIRPLDISGQGYNNWIFMSTHYWDEDPQGLWTLGLENKGYYYNTGTLYYCTLLLYGTAEDMTARPQTPQESHCPLSIVAELCLISSKQWWWLYSHTQQPVTKGQDSCHPPTTPARQLDQRLHCLFPAPHAGSASEPLQGLSPLAAILAISLGPWCCPC
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida (By similarity). Plays also a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing and activation of proteins such as IGF2 (By similarity). May also participate in folliculogenesis in the ovaries (By similarity). {ECO:0000250|UniProtKB:P29121, ECO:0000250|UniProtKB:Q6UW60}.
uniprot
proteins
mass_dalton
75740
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q6UW60}.; PTM: Synthesized in the endoplasmic reticulum as a zymogen, is matured by autocatalytic cleavage between the prodomain and the catalytic domain. {ECO:0000250|UniProtKB:Q6UW60}.
uniprot
proteins
protein_family
Furin subfamily
uniprot
proteins
protein_family
Peptidase S8 family
uniprot
proteins
pubmed
1448111
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21080038
uniprot
proteins
sequence_length
678
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000305|PubMed:21080038}.
uniprot
proteins