Fgr
entrez
79113
canonical
uniprot
Q6P6U0
canonical
ensembl
ENSRNOG00000009912
resolver
ensembl
ENSRNOG00055024231
resolver
ensembl
ENSRNOG00060027348
resolver
ensembl
ENSRNOG00065028857
resolver
ensp
ENSRNOP00000013779
resolver
ensp
ENSRNOP00055033841
resolver
ensp
ENSRNOP00060039519
resolver
ensp
ENSRNOP00065040893
resolver
enst
ENSRNOT00000013778
resolver
enst
ENSRNOT00055041597
resolver
enst
ENSRNOT00060047477
resolver
enst
ENSRNOT00065049807
resolver
genesymbol
Fgr
resolver
uniprot
Q63206
resolver
uniprot_entry
FGR_RAT
resolver
uniprot_sec
Q63206
resolver
activity_regulation
ACTIVITY REGULATION: Activated by autophosphorylation. Prior phosphorylation at Tyr-511 by SRC inhibits ulterior autophosphorylation at Tyr-400. Activated by phorbol myristate acetate, phosphatidic acid and poly-Lys. Binding (via SH2 domain) of HCLS1 that is already phosphorylated by SYK strongly increases kinase activity. {ECO:0000269|PubMed:7515063, ECO:0000269|PubMed:9183008}.
uniprot
proteins
amino_acid_sequence
MGCVFCKKLEPAPKEDVGLEGDFRSQGAEERYYPDPTQGRSSSISPQPISPAFLNVGNIRSVSGTGVTIFVALYDYEARTGDDLTFTKGEKFHILNNTEYDWWEARSLSSGRTGYVPSNYVAPVDSIQAEEWYFGKISRKDAERQLLSDGNPQGAFLIRESETTKGAYSLSIRDWDQNRGDHIKHYKIRKLDMGGYYITTRAQFESVQDLVRHYMEVNDGLCYLLTAPCMVMKPQTLGLAKDAWEIDRNSIALDRRLGTGCFGDVWLGTWNCSTKVAVKTLKPGTMSPKAFLEEAQIMKLLRHDKLVQLYAVVSEEPIYIVTEFMCYGSLLDFLKDRKGHNLMLPNLVDMAAQVAEGMAYMERMNYIHRDLRAANILVGEHLICKIADFGLARLIVDDEYNPQQGTKFPIKWTAPEAALFGRFTVKSDVWSFGILLTELITKGRVPYPGMNNREVLEQVEHGYHMPCPPGCPVSLYEVMEQTWRLDPEERPTFEYLQSFLEDYFTSTEPQYQPGDQT
uniprot
proteins
ec_number
2.7.10.2
uniprot
proteins
function
FUNCTION: Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors devoid of kinase activity and contributes to the regulation of immune responses, including neutrophil, monocyte, macrophage and mast cell functions, cytoskeleton remodeling in response to extracellular stimuli, phagocytosis, cell adhesion and migration. Promotes mast cell degranulation, release of inflammatory cytokines and IgE-mediated anaphylaxis. Acts downstream of receptors that bind the Fc region of immunoglobulins, such as MS4A2/FCER1B, FCER1G and FCGR2. Acts downstream of ITGB1 and ITGB2, and regulates actin cytoskeleton reorganization, cell spreading and adhesion. Depending on the context, activates or inhibits cellular responses. Functions as a negative regulator of ITGB2 signaling, phagocytosis and SYK activity in monocytes. Required for normal ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in neutrophils and macrophages. Functions as a positive regulator of cell migration and regulates cytoskeleton reorganization via RAC1 activation. Phosphorylates SYK (in vitro) and promotes SYK-dependent activation of AKT1 and MAP kinase signaling. Phosphorylates PLD2 in antigen-stimulated mast cells, leading to PLD2 activation and the production of the signaling molecules lysophosphatidic acid and diacylglycerol. Promotes activation of PIK3R1. Phosphorylates FASLG, and thereby regulates its ubiquitination and subsequent internalization. Phosphorylates ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1, PTK2B/PYK2 and VAV2 (By similarity). Phosphorylates HCLS1 that has already been phosphorylated by SYK, but not unphosphorylated HCLS1. Together with CLNK, it acts as a negative regulator of natural killer cell-activating receptors and inhibits interferon-gamma production (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P14234, ECO:0000269|PubMed:10066823, ECO:0000269|PubMed:15282299, ECO:0000269|PubMed:21746961, ECO:0000269|PubMed:8611520, ECO:0000269|PubMed:9183008}.
uniprot
proteins
mass_dalton
58821
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Becomes ubiquitinated in response to ITGB2 signaling; this does not lead to degradation (By similarity). {ECO:0000250}.; PTM: Phosphorylated. Autophosphorylated on tyrosine residues. Becomes phosphorylated in response to FCGR2 engagement, cell adhesion and signaling by ITGB2 (By similarity). Prior phosphorylation at Tyr-511 by SRC inhibits ulterior autophosphorylation at Tyr-400. {ECO:0000250, ECO:0000269|PubMed:7515063}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
SRC subfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
10066823
uniprot
proteins
pubmed
15282299
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18247338
uniprot
proteins
pubmed
21746961
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7515063
uniprot
proteins
pubmed
8611520
uniprot
proteins
pubmed
9183008
uniprot
proteins
sequence_length
517
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, ruffle membrane {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Mitochondrion inner membrane. Mitochondrion intermembrane space. Note=Colocalizes with actin fibers at membrane ruffles (By similarity). Detected at plasma membrane lipid rafts. Detected in mitochondrial intermembrane space and at inner membranes. {ECO:0000250}.
uniprot
proteins