Cd81
entrez
12520
canonical
uniprot
P35762
canonical
ensembl
ENSMUSG00000037706
resolver
ensp
ENSMUSP00000043768
resolver
enst
ENSMUST00000037941
resolver
genesymbol
Cd81
resolver
genesymbol_syn
Tapa1
resolver
uniprot
Q91V78
resolver
uniprot_entry
CD81_MOUSE
resolver
uniprot_sec
Q91V78
resolver
amino_acid_sequence
MGVEGCTKCIKYLLFVFNFVFWLAGGVILGVALWLRHDPQTTSLLYLELGNKPAPNTFYVGIYILIAVGAVMMFVGFLGCYGAIQESQCLLGTFFTCLVILFACEVAAGIWGFVNKDQIAKDVKQFYDQALQQAVMDDDANNAKAVVKTFHETLNCCGSNALTTLTTTILRNSLCPSGGNILTPLLQQDCHQKIDELFSGKLYLIGIAAIVVAVIMIFEMILSMVLCCGIRNSSVY
uniprot
proteins
function
FUNCTION: Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the cell surface of activated B cells (PubMed:23499492). Upon initial encounter with a microbial pathogen, enables the assembly of CD19-CR2 and B cell receptor complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and humoral immune response (By similarity). In T cells, associates with CD4 or CD8 coreceptors and defines the maturation state of antigen-induced synapses with B cells (By similarity). Facilitates localization of CD3 in these immune synapses, required for costimulation and sustained activation of T cells, preferentially triggering T helper type 2 immune response (PubMed:11046035). Can act both as positive and negative regulator of homotypic or heterotypic cell-cell fusion processes. In myoblasts, associates with another tetraspanin CD9 in complex with PTGFRN and inhibits myotube fusion during muscle regeneration (PubMed:23575678). In macrophages, associates with CD9 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles. Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption. Positively regulates sperm-egg fusion and may be involved in the acrosome reaction (PubMed:16380109, PubMed:17290409). Regulates protein trafficking in intracellular compartments. In T cells, associates with dNTPase SAMHD1 and defines its subcellular location, enabling its degradation by the proteasome and thereby controlling intracellular dNTP levels (By similarity). Also regulates integrin-dependent migration of macrophages, particularly relevant for inflammatory response in the lung (PubMed:18662991). {ECO:0000250|UniProtKB:P60033, ECO:0000269|PubMed:11046035, ECO:0000269|PubMed:16380109, ECO:0000269|PubMed:17290409, ECO:0000269|PubMed:18662991, ECO:0000269|PubMed:23499492, ECO:0000269|PubMed:23575678}.; FUNCTION: (Microbial infection) Specifically required for Plasmodium yoelii infectivity of hepatocytes, controlling sporozoite entry in hepatocytes via the parasitophorous vacuole and subsequent parasite differentiation to exoerythrocytic forms. {ECO:0000269|PubMed:12483205}.
uniprot
proteins
mass_dalton
25815
uniprot
proteins
post_translational_modification
PTM: Not glycosylated. {ECO:0000305}.; PTM: Likely constitutively palmitoylated at low levels. Protein palmitoylation is up-regulated upon coligation of BCR and CD9-C2R-CD81 complexes in lipid rafts. {ECO:0000250|UniProtKB:P60033}.
uniprot
proteins
protein_family
Tetraspanin (TM4SF) family
uniprot
proteins
pubmed
10915772
uniprot
proteins
pubmed
11046035
uniprot
proteins
pubmed
11673522
uniprot
proteins
pubmed
12483205
uniprot
proteins
pubmed
12796480
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16380109
uniprot
proteins
pubmed
16395393
uniprot
proteins
pubmed
1650385
uniprot
proteins
pubmed
17290409
uniprot
proteins
pubmed
18662991
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23213457
uniprot
proteins
pubmed
23499492
uniprot
proteins
pubmed
23575678
uniprot
proteins
pubmed
23665349
uniprot
proteins
pubmed
26116703
uniprot
proteins
sequence_length
236
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23213457}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:P60033}; Multi-pass membrane protein {ECO:0000255}. Note=Associates with CLDN1 and the CLDN1-CD81 complex localizes to the basolateral cell membrane. {ECO:0000250|UniProtKB:P60033}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..33; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P60033"; TRANSMEM 64..84; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P60033"; TRANSMEM 90..112; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P60033"; TRANSMEM 202..224; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P60033
uniprot
proteins