Tacr2
entrez
25007
canonical
uniprot
P16610
canonical
ensembl
ENSRNOG00000050658
resolver
ensembl
ENSRNOG00055014829
resolver
ensembl
ENSRNOG00060007430
resolver
ensembl
ENSRNOG00065003318
resolver
ensp
ENSRNOP00000067266
resolver
ensp
ENSRNOP00055020727
resolver
ensp
ENSRNOP00060009259
resolver
ensp
ENSRNOP00065003380
resolver
enst
ENSRNOT00000071394
resolver
enst
ENSRNOT00055025387
resolver
enst
ENSRNOT00060012244
resolver
enst
ENSRNOT00065004730
resolver
genesymbol
Tacr2
resolver
genesymbol_syn
Tac2r
resolver
uniprot_entry
NK2R_RAT
resolver
amino_acid_sequence
MGTRAIVSDANILSGLESNATGVTAFSMPGWQLALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAIIAGIWLVALALASPQCFYSTITVDEGATKCVVAWPNDNGGKMLLLYHLVVFVLIYFLPLLVMFGAYSVIGLTLWKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVLTFAICWLPYHLYFILGTFQEDIYYHKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTEEDRLELTHTPSLSRRVNRCHTKETLFMTGDMTHSEATNGQVGSPQDGEPAGPICKAQA
uniprot
proteins
function
FUNCTION: Receptor for the tachykinin substance K (neurokinin A), also able to bind and respond to tachynins substance P and neurokinin B/neuromedin-K (PubMed:1370820). The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P (PubMed:1370820). Substance K binding to its receptor triggers G protein-coupled receptor signaling via activation of phosphatidylinositol hydrolysis by phospholipase C (PubMed:1370820). Substance K binding also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP) (PubMed:1370820). {ECO:0000269|PubMed:1370820}.
uniprot
proteins
mass_dalton
43853
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
1370820
uniprot
proteins
pubmed
2480781
uniprot
proteins
sequence_length
390
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P21452}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 33..56; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 70..90; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 108..129; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 150..170; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 197..218; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 252..272; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 291..310; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins