Spry3
entrez
236576
canonical
uniprot
Q3UUD2
canonical
genesymbol
Spry3
resolver
uniprot_entry
SPRY3_MOUSE
resolver
amino_acid_sequence
MDATVIDELQQILPIEQLRSTHASNDYVERPPAPCKQALSSPSLIVQTHKSDWSLATMPTALPRSISQCHQLQPLPQHLSQSSISSSMSQSTTASDQRLLASITPSPSGQSIIRTQPGAGAHPKVDGALKGEAEQSVGHSSDHLFICEECGRCKCVPCTAVRPLPSCWMCNQRCLCSAESLLDYGTCLCCVKGLFYHCSTDDEDNCADEPCSCGPSSCFIRWAAMSLISLFLPCLCCYLPTRGCLHMCQQGYDSLRRPGCRCKRHTNTVCRKISSSSSPFPKAQEKSV
uniprot
proteins
function
FUNCTION: Inhibits neurite branching, arbor length and neurite complexity (PubMed:26089202). Inhibits EGF-mediated p42/44 ERK signaling (PubMed:16877379). Negatively regulates the MAPK cascade, resulting in a reduction of extracellular matrix protein accumulation (By similarity). May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis (By similarity). {ECO:0000250|UniProtKB:O43610, ECO:0000269|PubMed:16877379, ECO:0000269|PubMed:26089202}.
uniprot
proteins
mass_dalton
31363
uniprot
proteins
mutagenesis
MUTAGEN 221; /note="R->D: Abolishes inhibition of EGF-mediated p42/44 ERK signaling."; /evidence="ECO:0000269|PubMed:16877379
uniprot
proteins
protein_family
Sprouty family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16877379
uniprot
proteins
pubmed
26089202
uniprot
proteins
sequence_length
288
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O43610}.
uniprot
proteins