TRIM26
entrez
7726
canonical
uniprot
Q12899
canonical
ensembl
ENSG00000137313
resolver
ensembl
ENSG00000226060
resolver
ensembl
ENSG00000228881
resolver
ensembl
ENSG00000230230
resolver
ensembl
ENSG00000231002
resolver
ensembl
ENSG00000231641
resolver
ensembl
ENSG00000234046
resolver
ensembl
ENSG00000234127
resolver
ensp
ENSP00000331131
resolver
ensp
ENSP00000373102
resolver
ensp
ENSP00000379806
resolver
ensp
ENSP00000389203
resolver
ensp
ENSP00000390258
resolver
ensp
ENSP00000391879
resolver
ensp
ENSP00000392805
resolver
ensp
ENSP00000393011
resolver
ensp
ENSP00000394371
resolver
ensp
ENSP00000394421
resolver
ensp
ENSP00000395491
resolver
ensp
ENSP00000396188
resolver
ensp
ENSP00000398545
resolver
ensp
ENSP00000402395
resolver
ensp
ENSP00000406707
resolver
ensp
ENSP00000407294
resolver
ensp
ENSP00000407876
resolver
ensp
ENSP00000408233
resolver
ensp
ENSP00000409182
resolver
ensp
ENSP00000410446
resolver
ensp
ENSP00000414248
resolver
ensp
ENSP00000415328
resolver
ensp
ENSP00000415755
resolver
ensp
ENSP00000416737
resolver
ensp
ENSP00000531776
resolver
ensp
ENSP00000531777
resolver
ensp
ENSP00000531778
resolver
ensp
ENSP00000531780
resolver
ensp
ENSP00000531781
resolver
ensp
ENSP00000531783
resolver
ensp
ENSP00000531786
resolver
ensp
ENSP00000531787
resolver
ensp
ENSP00000531788
resolver
ensp
ENSP00000531789
resolver
ensp
ENSP00000531790
resolver
ensp
ENSP00000531791
resolver
ensp
ENSP00000531792
resolver
ensp
ENSP00000531793
resolver
ensp
ENSP00000531794
resolver
ensp
ENSP00000531795
resolver
ensp
ENSP00000531796
resolver
ensp
ENSP00000531797
resolver
ensp
ENSP00000531798
resolver
ensp
ENSP00000531799
resolver
ensp
ENSP00000531800
resolver
ensp
ENSP00000589619
resolver
ensp
ENSP00000589620
resolver
ensp
ENSP00000589621
resolver
ensp
ENSP00000633493
resolver
ensp
ENSP00000633494
resolver
ensp
ENSP00000633496
resolver
ensp
ENSP00000633497
resolver
ensp
ENSP00000633498
resolver
ensp
ENSP00000633499
resolver
enst
ENST00000327357
resolver
enst
ENST00000383607
resolver
enst
ENST00000396558
resolver
enst
ENST00000415923
resolver
enst
ENST00000422349
resolver
enst
ENST00000425523
resolver
enst
ENST00000425831
resolver
enst
ENST00000427535
resolver
enst
ENST00000428486
resolver
enst
ENST00000432326
resolver
enst
ENST00000433314
resolver
enst
ENST00000436219
resolver
enst
ENST00000437089
resolver
enst
ENST00000438384
resolver
enst
ENST00000438908
resolver
enst
ENST00000439094
resolver
enst
ENST00000445259
resolver
enst
ENST00000447711
resolver
enst
ENST00000450392
resolver
enst
ENST00000453195
resolver
enst
ENST00000454678
resolver
enst
ENST00000455000
resolver
enst
ENST00000456093
resolver
enst
ENST00000456770
resolver
enst
ENST00000861717
resolver
enst
ENST00000861718
resolver
enst
ENST00000861719
resolver
enst
ENST00000861722
resolver
enst
ENST00000861724
resolver
enst
ENST00000861728
resolver
enst
ENST00000861729
resolver
enst
ENST00000861730
resolver
enst
ENST00000861731
resolver
enst
ENST00000861733
resolver
enst
ENST00000861734
resolver
enst
ENST00000861735
resolver
enst
ENST00000861736
resolver
enst
ENST00000861737
resolver
enst
ENST00000861738
resolver
enst
ENST00000861739
resolver
enst
ENST00000861740
resolver
enst
ENST00000919560
resolver
enst
ENST00000919561
resolver
enst
ENST00000919562
resolver
enst
ENST00000963434
resolver
enst
ENST00000963435
resolver
enst
ENST00000963437
resolver
enst
ENST00000963438
resolver
enst
ENST00000963439
resolver
enst
ENST00000963440
resolver
genesymbol
TRIM26
resolver
genesymbol_syn
RNF95
resolver
genesymbol_syn
ZNF173
resolver
hgnc
HGNC:12962
resolver
uniprot
A6NG96
resolver
uniprot
Q5SRL2
resolver
uniprot_entry
TRI26_HUMAN
resolver
uniprot_sec
A6NG96
resolver
uniprot_sec
Q5SRL2
resolver
amino_acid_sequence
MATSAPLRSLEEEVTCSICLDYLRDPVTIDCGHVFCRSCTTDVRPISGSRPVCPLCKKPFKKENIRPVWQLASLVENIERLKVDKGRQPGEVTREQQDAKLCERHREKLHYYCEDDGKLLCVMCRESREHRPHTAVLMEKAAQPHREKILNHLSTLRRDRDKIQGFQAKGEADILAALKKLQDQRQYIVAEFEQGHQFLREREEHLLEQLAKLEQELTEGREKFKSRGVGELARLALVISELEGKAQQPAAELMQDTRDFLNRYPRKKFWVGKPIARVVKKKTGEFSDKLLSLQRGLREFQGKLLRDLEYKTVSVTLDPQSASGYLQLSEDWKCVTYTSLYKSAYLHPQQFDCEPGVLGSKGFTWGKVYWEVEVEREGWSEDEEEGDEEEEGEEEEEEEEAGYGDGYDDWETDEDEESLGDEEEEEEEEEEEVLESCMVGVARDSVKRKGDLSLRPEDGVWALRLSSSGIWANTSPEAELFPALRPRRVGIALDYEGGTVTFTNAESQELIYTFTATFTRRLVPFLWLKWPGTRLLLRP
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Also plays a central role in determining the response to different forms of oxidative stress by controlling levels of DNA glycosylases NEIL1, NEIL3 and NTH1 that are involved in repair of damaged DNA (PubMed:29610152, PubMed:36232914). Promotes nuclear IRF3 ubiquitination and proteasomal degradation (PubMed:25763818). Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1. Positively regulates LPS-mediated inflammatory innate immune response by catalyzing the 'Lys-11'-linked polyubiquitination of TAB1 to enhance its activation and subsequent NF-kappa-B and MAPK signaling (PubMed:34017102). In a manner independent of its catalytic activity, inhibits WWP2, a SOX2-directed E3 ubiquitin ligase, and thus protects SOX2 from polyubiquitination and proteasomal degradation (PubMed:34732716). Ubiquitinates the histone acetyltransferase protein complex component PHF20 and thereby triggers its degradation in the nucleus after its recruitment by the histone demethylase KDM6B, serving as a scaffold protein (PubMed:23452852). Upon induction by TGF-beta, ubiquitinates the TFIID component TAF7 for proteasomal degradation (PubMed:29203640). Induces ferroptosis by ubiquitinating SLC7A11, a critical protein for lipid reactive oxygen species (ROS) scavenging (By similarity). Inhibits directly hepatitis B virus replication by mediating HBX ubiquitination and subsequent degradation (PubMed:35872575). {ECO:0000250|UniProtKB:Q99PN3, ECO:0000269|PubMed:23452852, ECO:0000269|PubMed:25763818, ECO:0000269|PubMed:26611359, ECO:0000269|PubMed:29203640, ECO:0000269|PubMed:29610152, ECO:0000269|PubMed:34017102, ECO:0000269|PubMed:34732716, ECO:0000269|PubMed:35872575, ECO:0000269|PubMed:36232914}.; FUNCTION: (Microbial infection) Promotes herpes simplex virus type 2/HHV-2 infection in vaginal epithelial cells by decreasing the nuclear localization of IRF3, the primary mediator of type I interferon activation. {ECO:0000269|PubMed:33419081}.
uniprot
proteins
mass_dalton
62166
uniprot
proteins
mutagenesis
MUTAGEN 16; /note="C->A: Strong loss of ubiquitination activity."; /evidence="ECO:0000269|PubMed:34017102
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinates upon viral infection. In turn, autoubiquitinated TRIM26 recruits NEMO and bridges TBK1-NEMO interaction. {ECO:0000269|PubMed:26611359}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16702430
uniprot
proteins
pubmed
21750715
uniprot
proteins
pubmed
23452852
uniprot
proteins
pubmed
25763818
uniprot
proteins
pubmed
26611359
uniprot
proteins
pubmed
29203640
uniprot
proteins
pubmed
29610152
uniprot
proteins
pubmed
33419081
uniprot
proteins
pubmed
34017102
uniprot
proteins
pubmed
34732716
uniprot
proteins
pubmed
35872575
uniprot
proteins
pubmed
36232914
uniprot
proteins
pubmed
8530076
uniprot
proteins
sequence_length
539
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25763818, ECO:0000269|PubMed:34017102, ECO:0000269|PubMed:35872575}. Nucleus {ECO:0000269|PubMed:25763818, ECO:0000269|PubMed:33419081}. Note=Viral infection mediates TRIM26 nuclear translocation. {ECO:0000269|PubMed:25763818}.
uniprot
proteins