Mrnip
entrez
68067
canonical
uniprot
Q9D1F5
canonical
ensembl
ENSMUSG00000020381
resolver
ensp
ENSMUSP00000020647
resolver
enst
ENSMUST00000020647
resolver
genesymbol
Mrnip
resolver
uniprot
Q9CX85
resolver
uniprot_entry
MRNIP_MOUSE
resolver
uniprot_sec
Q9CX85
resolver
amino_acid_sequence
MAPAQQSRVLRCCSCHIFQAHQVKKSLKWTCKACGEKQSFVRAYGEGSGADCRRHVQKLNLLQGQVSELSLRSVEEAVNGSEEENAGPLQAEAGSQQAPSKPLESRWLKYLDKGCEDQELDRGRPALKTQLSTSAERPSSPAQPRKRKWNQRTGQPAHSLHGQGVDSVEDNFEHQDSTGLFGTEQQGTSPALSTANHTRELGFPRWKLPSPVTQVNAPSSKWARFLLAPGNSPQVDEKPSPLQEATMLADLAQGTVENKTPVEGHFSRAPAIRPPQAIHTTTPQLDRPDRKTREQPRDMGTPRADGRPLAQGTQKAPPLQLHNLFTTGEDFDDDL
uniprot
proteins
function
FUNCTION: Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex. Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair. {ECO:0000250|UniProtKB:Q6NTE8}.
uniprot
proteins
mass_dalton
36897
uniprot
proteins
post_translational_modification
PTM: Phosphorylated; phosphorylation is constitutive and occurs in the absence of any DNA-damaging stimulus. Phosphorylation is necessary for its nuclear retention. {ECO:0000250|UniProtKB:Q6NTE8}.
uniprot
proteins
protein_family
MRNIP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
335
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6NTE8}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q6NTE8}. Note=Recruited to sites of DNA damage. Phosphorylation induces its nuclear localization and promotes genome stability. {ECO:0000250|UniProtKB:Q6NTE8}.
uniprot
proteins