Mt-co1
entrez
26195
canonical
uniprot
P05503
canonical
genesymbol
Mt-co1
resolver
genesymbol_syn
COX1
resolver
genesymbol_syn
Coi
resolver
genesymbol_syn
Mtco1
resolver
uniprot
Q8HIC9
resolver
uniprot_entry
COX1_RAT
resolver
uniprot_entry
Q8HIC9_RAT
resolver
amino_acid_sequence
MLVNRWLFSTNHKDIGTLYLLFGAWAGMVGTALSILIRAELGQPGALLGDDQIYNVIVTAHAFVMIFFMVMPMMIGGFGNWLVPLMIGAPDMAFPRMNNMSFWLLPPSFLLLLASSMVEAGAGTGWTVYPPLAGNLAHAGASVDLTIFSLHLAGVSSILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLLLSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLFWFFGHPEVYILILPGFGIISHVVTYYSGKKEPFGYMGMVWAMMSIGFLGFIVWAHHMFTVGLDVDTRAYFTSATMIIAIPTGVKVFSWLATLHGGNIKWSPAMLWALGFIFLFTVGGLTGIVLSNSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMAGFVHWFPLFSGYTLNDTWAKAHFAIMFVGVNMTFFPQHFLGLAGMPRRYSDYPDAYTTWNTVSSMGSFISLTAVLVMIFMIWEAFASKREVLSISYSSTNLEWLHGCPPPYHTFEEPSYVKVK
uniprot
proteins
ec_number
7.1.1.9
uniprot
proteins
function
FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00401}.
uniprot
proteins
mass_dalton
56845
uniprot
proteins
pathway_participation
PATHWAY: Energy metabolism; oxidative phosphorylation. {ECO:0000250|UniProtKB:P00401}.
uniprot
proteins
protein_family
Heme-copper respiratory oxidase family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
1664046
uniprot
proteins
pubmed
2504926
uniprot
proteins
pubmed
6300770
uniprot
proteins
sequence_length
514
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00396}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P00396}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..40; /note="Helical; Name=I"; /evidence="ECO:0000250|UniProtKB:P00396"; TRANSMEM 51..86; /note="Helical; Name=II"; /evidence="ECO:0000250|UniProtKB:P00396"; TRANSMEM 95..117; /note="Helical; Name=III"; /evidence="ECO:0000250|UniProtKB:P00396"; TRANSMEM 141..170; /note="Helical; Name=IV"; /evidence="ECO:0000250|UniProtKB:P00396"; TRANSMEM 183..212; /note="Helical; Name=V"; /evidence="ECO:0000250|UniProtKB:P00396"; TRANSMEM 228..261; /note="Helical; Name=VI"; /evidence="ECO:0000250|UniProtKB:P00396"; TRANSMEM 270..286; /note="Helical; Name=VII"; /evidence="ECO:0000250|UniProtKB:P00396"; TRANSMEM 299..327; /note="Helical; Name=VIII"; /evidence="ECO:0000250|UniProtKB:P00396"; TRANSMEM 336..357; /note="Helical; Name=IX"; /evidence="ECO:0000250|UniProtKB:P00396"; TRANSMEM 371..400; /note="Helical; Name=X"; /evidence="ECO:0000250|UniProtKB:P00396"; TRANSMEM 407..433; /note="Helical; Name=XI"; /evidence="ECO:0000250|UniProtKB:P00396"; TRANSMEM 447..478; /note="Helical; Name=XII"; /evidence="ECO:0000250|UniProtKB:P00396
uniprot
proteins