Picalm
entrez
233489
canonical
uniprot
Q7M6Y3
canonical
ensembl
ENSMUSG00000039361
resolver
ensp
ENSMUSP00000051092
resolver
ensp
ENSMUSP00000146386
resolver
ensp
ENSMUSP00000146501
resolver
ensp
ENSMUSP00000146541
resolver
ensp
ENSMUSP00000146659
resolver
ensp
ENSMUSP00000147016
resolver
ensp
ENSMUSP00000161978
resolver
ensp
ENSMUSP00000161979
resolver
ensp
ENSMUSP00000161980
resolver
ensp
ENSMUSP00000161981
resolver
ensp
ENSMUSP00000161982
resolver
ensp
ENSMUSP00000161983
resolver
ensp
ENSMUSP00000161984
resolver
ensp
ENSMUSP00000161985
resolver
ensp
ENSMUSP00000161987
resolver
ensp
ENSMUSP00000161989
resolver
ensp
ENSMUSP00000161991
resolver
ensp
ENSMUSP00000161996
resolver
ensp
ENSMUSP00000161998
resolver
genesymbol
Picalm
resolver
genesymbol_syn
Calm
resolver
genesymbol_syn
Fit1
resolver
genesymbol_syn
mKIAA4114
resolver
uniprot
Q3TD51
resolver
uniprot
Q3TS04
resolver
uniprot
Q570Z8
resolver
uniprot
Q811P1
resolver
uniprot
Q8BUF6
resolver
uniprot
Q8CIH8
resolver
uniprot
Q8R0A9
resolver
uniprot
Q8R3E1
resolver
uniprot
Q8VDN5
resolver
uniprot
Q921L0
resolver
uniprot_entry
PICAL_MOUSE
resolver
uniprot_entry
Q3TD51_MOUSE
resolver
uniprot_entry
Q570Z8_MOUSE
resolver
uniprot_sec
Q3TS04
resolver
uniprot_sec
Q811P1
resolver
uniprot_sec
Q8BUF6
resolver
uniprot_sec
Q8CIH8
resolver
uniprot_sec
Q8R0A9
resolver
uniprot_sec
Q8R3E1
resolver
uniprot_sec
Q8VDN5
resolver
uniprot_sec
Q921L0
resolver
amino_acid_sequence
MSGQSLTDRITAAQHSVTGSAVSKTVCKATTHEIMGPKKKHLDYLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSNFLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFMLLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGKKIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFSTPSSSNSTSKLPNDLLDLQQPTFHPSVHAMSAAPQGASTWGDPFSATLDAVEDAIPSLNPFLTKSSGDVHLPIASDVSTFTTRTPTHEMFVGFSPSPVAQPHSSAGLNVDFESVFGNKSTNVAVDSGGFDELGGLLKPTVASQNQSLPVAKLPPNKLVSDDLDSSLANLVGNLGIGNGTTKNDVSWSQPGEKKLTGGSNWQPKVAPTTAWSAATMNGMHFPQYAPPVMAYPATTPTGMIGYGIPPQMGSVPVMTQPTLIYSQPVMRPPNPFGPVSGAQIQFM
uniprot
proteins
function
FUNCTION: Cytoplasmic adapter protein that plays a critical role in clathrin-mediated endocytosis which is important in processes such as internalization of cell receptors, synaptic transmission or removal of apoptotic cells. Recruits AP-2 and attaches clathrin triskelions to the cytoplasmic side of plasma membrane leading to clathrin-coated vesicles (CCVs) assembly. Furthermore, regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature. In addition to binding to clathrin, mediates the endocytosis of small R-SNARES (Soluble NSF Attachment Protein REceptors) between plasma membranes and endosomes including VAMP2, VAMP3, VAMP4, VAMP7 or VAMP8. In turn, PICALM-dependent SNARE endocytosis is required for the formation and maturation of autophagic precursors. Modulates thereby autophagy and the turnover of autophagy substrates such as MAPT/TAU or amyloid precursor protein cleaved C-terminal fragment (APP-CTF). {ECO:0000250|UniProtKB:Q13492, ECO:0000269|PubMed:12832620, ECO:0000269|PubMed:22363754}.
uniprot
proteins
mass_dalton
71543
uniprot
proteins
protein_family
PICALM/SNAP91 family
uniprot
proteins
pubmed
12832620
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22363754
uniprot
proteins
pubmed
9292517
uniprot
proteins
sequence_length
660
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q13492}. Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:Q13492}. Golgi apparatus {ECO:0000250|UniProtKB:Q13492}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q13492}. Nucleus {ECO:0000250|UniProtKB:Q13492}. Note=Colocalized with clathrin in the Golgi area. Interaction with PIMREG may target PICALM to the nucleus in some cells. {ECO:0000250|UniProtKB:Q13492}.
uniprot
proteins