TNFSF4
entrez
7292
canonical
uniprot
P23510
canonical
ensembl
ENSG00000117586
resolver
ensp
ENSP00000281834
resolver
ensp
ENSP00000356691
resolver
genesymbol
TNFSF4
resolver
genesymbol
TNLG2B
resolver
genesymbol_syn
TXGP1
resolver
hgnc
HGNC:11934
resolver
uniprot
A0A024R937
resolver
uniprot
A0A0U5CJ97
resolver
uniprot
Q5JZA5
resolver
uniprot
Q8IV74
resolver
uniprot
Q9HCN9
resolver
uniprot_entry
A0A024R937_HUMAN
resolver
uniprot_entry
TNFL4_HUMAN
resolver
uniprot_sec
A0A0U5CJ97
resolver
uniprot_sec
Q5JZA5
resolver
uniprot_sec
Q8IV74
resolver
uniprot_sec
Q9HCN9
resolver
amino_acid_sequence
MERVQPLEENVGNAARPRFERNKLLLVASVIQGLGLLLCFTYICLHFSALQVSHRYPRIQSIKVQFTEYKKEKGFILTSQKEDEIMKVQNNSVIINCDGFYLISLKGYFSQEVNISLHYQKDEEPLFQLKKVRSVNSLMVASLTYKDKVYLNVTTDNTSLDDFHVNGGELILIHQNPGEFCVL
uniprot
proteins
disease_involvement
DISEASE: Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. {ECO:0000269|PubMed:18059267}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry. The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T-cell-APC interaction and the functional consequences of T-cell activation, thereby destabilizing peripheral tolerance.
uniprot
proteins
function
FUNCTION: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.
uniprot
proteins
mass_dalton
21050
uniprot
proteins
protein_family
Tumor necrosis factor family
uniprot
proteins
pubmed
11197696
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16905106
uniprot
proteins
pubmed
18059267
uniprot
proteins
pubmed
1996093
uniprot
proteins
pubmed
7913952
uniprot
proteins
pubmed
8076595
uniprot
proteins
sequence_length
183
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 24..50; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins