Foxa1
entrez
15375
canonical
uniprot
P35582
canonical
ensembl
ENSMUSG00000035451
resolver
ensp
ENSMUSP00000041118
resolver
enst
ENSMUST00000044380
resolver
genesymbol
Foxa1
resolver
genesymbol_syn
Hnf3a
resolver
genesymbol_syn
Tcf-3a
resolver
genesymbol_syn
Tcf3a
resolver
uniprot
Q4VA63
resolver
uniprot
Q61108
resolver
uniprot_entry
FOXA1_MOUSE
resolver
uniprot_sec
Q4VA63
resolver
uniprot_sec
Q61108
resolver
amino_acid_sequence
MLGTVKMEGHESNDWNSYYADTQEAYSSVPVSNMNSGLGSMNSMNTYMTMNTMTTSGNMTPASFNMSYANTGLGAGLSPGAVAGMPGASAGAMNSMTAAGVTAMGTALSPGGMGSMGAQPATSMNGLGPYAAAMNPCMSPMAYAPSNLGRSRAGGGGDAKTFKRSYPHAKPPYSYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYYRQNQQRWQNSIRHSLSFNDCFVKVARSPDKPGKGSYWTLHPDSGNMFENGCYLRRQKRFKCEKQPGAGGGSGGGGSKGGPESRKDPSGPGNPSAESPLHRGVHGKASQLEGAPAPGPAASPQTLDHSGATATGGASELKSPASSSAPPISSGPGALASVPPSHPAHGLAPHESQLHLKGDPHYSFNHPFSINNLMSSSEQQHKLDFKAYEQALQYSPYGATLPASLPLGSASVATRSPIEPSALEPAYYQGVYSRPVLNTS
uniprot
proteins
function
FUNCTION: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas, lungs and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles. Plays a role in prostate morphogenesis and epithelial cell differentiation. FOXA1 and FOXA2 are essential for hepatic specification. FOXA1 and FOXA2 are required for morphogenesis and cell differentiation during formation of the lung. FOXA1 and FOXA2 are involved in bile duct formation; they positively regulate the binding of glucocorticoid receptor/NR3C1 to the IL6 promoter. FOXA1 and FOXA2 regulate multiple phases of midbrain dopaminergic neuron development; they regulate expression of NEUROG2 at the beginning of mDA neurogenesis and of NR4A2 and EN1 in immature mDA neurons. Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription. Inhibits NKX2-1-mediated transcription from the SFTPC promoter in lung epithel independently from DNA-binding. Involved in regulation of apoptosis. Involved in cell cycle regulation. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; activates the GCG promoter. {ECO:0000250, ECO:0000269|PubMed:10049364, ECO:0000269|PubMed:11864602, ECO:0000269|PubMed:15668254, ECO:0000269|PubMed:15748903, ECO:0000269|PubMed:15959514, ECO:0000269|PubMed:15987773, ECO:0000269|PubMed:17596284, ECO:0000269|PubMed:19141476, ECO:0000269|PubMed:19436110}.
uniprot
proteins
mass_dalton
48854
uniprot
proteins
pubmed
10049364
uniprot
proteins
pubmed
11571307
uniprot
proteins
pubmed
11864602
uniprot
proteins
pubmed
15252040
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15668254
uniprot
proteins
pubmed
15748903
uniprot
proteins
pubmed
15959514
uniprot
proteins
pubmed
15987773
uniprot
proteins
pubmed
17220277
uniprot
proteins
pubmed
17596284
uniprot
proteins
pubmed
19141476
uniprot
proteins
pubmed
19436110
uniprot
proteins
pubmed
8034310
uniprot
proteins
sequence_length
468
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00089, ECO:0000269|PubMed:15987773}.
uniprot
proteins