Pabir1
entrez
309420
canonical
uniprot
Q6AYT4
canonical
ensembl
ENSRNOG00000051051
resolver
ensembl
ENSRNOG00055031640
resolver
ensembl
ENSRNOG00060022618
resolver
ensembl
ENSRNOG00065025486
resolver
ensp
ENSRNOP00000068087
resolver
ensp
ENSRNOP00000108172
resolver
ensp
ENSRNOP00055045274
resolver
ensp
ENSRNOP00060032418
resolver
ensp
ENSRNOP00065035997
resolver
enst
ENSRNOT00000076544
resolver
enst
ENSRNOT00000123517
resolver
enst
ENSRNOT00055054780
resolver
enst
ENSRNOT00060039207
resolver
enst
ENSRNOT00065043890
resolver
genesymbol
Pabir1
resolver
genesymbol_syn
Fam122a
resolver
uniprot_entry
PBIR1_RAT
resolver
amino_acid_sequence
MAQEKMELDLELPAGTGASPAEGGGPGSGGLRRSNSAPLIHGLSDSSPVFQAEAPSARRNSTTFPSRHGLLLPASPVRMHSSRLHQIKQEEGMDLINRETVHEREVQTAMQISHSWEESFSLSDNDVEKSASPKRIDFIPVSPAPSPTRGIGKQCFSPSLQSFVSSNGLPPSPIPSPTTRFTTRRSQSPINCIRPSVLGPLKRKCEMETDYQPKRFFQGITNMLSSDVAQLSEPGVCVSSDTLDGNSSSAGSSCNSPAKVSTTTDSPVSPAQAASPFIPVDELSSK
uniprot
proteins
function
FUNCTION: Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity (By similarity). Inhibits PP2A activity by blocking the substrate binding site on PPP2R2A and the active site of PPP2CA (By similarity). Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) (By similarity). Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby releasing G2/M checkpoint (By similarity). {ECO:0000250|UniProtKB:Q96E09}.
uniprot
proteins
mass_dalton
30472
uniprot
proteins
post_translational_modification
PTM: CHEK1-mediated phosphorylation at Ser-36 negatively regulates its ability to inhibit serine/threonine-protein phosphatase 2A (PP2A) activity. Phosphorylation leads to its release from the PP2A complex and its sequestration by 14-3-3 proteins in the cytoplasm resulting in its inability to translocate to the nucleus, where it otherwise inhibits PP2A. {ECO:0000250|UniProtKB:Q96E09}.
uniprot
proteins
protein_family
FAM122 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
286
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96E09}. Cytoplasm {ECO:0000250|UniProtKB:Q96E09}. Note=The CHEK1-mediated Ser-36 phosphorylated form is sequestered by 14-3-3 proteins in the cytoplasm and fails to translocate to the nucleus, where it otherwise inhibits serine/threonine-protein phosphatase 2A. {ECO:0000250|UniProtKB:Q96E09}.
uniprot
proteins