SWAP70
entrez
23075
canonical
uniprot
Q9UH65
canonical
ensembl
ENSG00000133789
resolver
ensp
ENSP00000315630
resolver
ensp
ENSP00000399056
resolver
enst
ENST00000318950
resolver
enst
ENST00000447399
resolver
genesymbol
SWAP70
resolver
genesymbol_syn
KIAA0640
resolver
hgnc
HGNC:17070
resolver
uniprot
B3KUB9
resolver
uniprot
D3DQV1
resolver
uniprot
E7EMB1
resolver
uniprot
O75135
resolver
uniprot
Q7LCY6
resolver
uniprot
Q9P061
resolver
uniprot
Q9P0Z8
resolver
uniprot_entry
B3KUB9_HUMAN
resolver
uniprot_entry
E7EMB1_HUMAN
resolver
uniprot_entry
SWP70_HUMAN
resolver
uniprot_sec
D3DQV1
resolver
uniprot_sec
O75135
resolver
uniprot_sec
Q7LCY6
resolver
uniprot_sec
Q9P061
resolver
uniprot_sec
Q9P0Z8
resolver
amino_acid_sequence
MGSLKEELLKAIWHAFTALDQDHSGKVSKSQLKVLSHNLCTVLKVPHDPVALEEHFRDDDEGPVSNQGYMPYLNRFILEKVQDNFDKIEFNRMCWTLCVKKNLTKNPLLITEEDAFKIWVIFNFLSEDKYPLIIVSEEIEYLLKKLTEAMGGGWQQEQFEHYKINFDDSKNGLSAWELIELIGNGQFSKGMDRQTVSMAINEVFNELILDVLKQGYMMKKGHRRKNWTERWFVLKPNIISYYVSEDLKDKKGDILLDENCCVESLPDKDGKKCLFLVKCFDKTFEISASDKKKKQEWIQAIHSTIHLLKLGSPPPHKEARQRRKELRKKQLAEQEELERQMKELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKLIRQQMEEQVAQKSSELEQYLQRVRELEDMYLKLQEALEDERQARQDEETVRKLQARLLEEESSKRAELEKWHLEQQQAIQTTEAEKQELENQRVLKEQALQEAMEQLEQLELERKQALEQYEEVKKKLEMATNKTKSWKDKVAHHEGLIRLIEPGSKNPHLITNWGPAAFTEAELEEREKNWKEKKTTE
uniprot
proteins
function
FUNCTION: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity). {ECO:0000250, ECO:0000269|PubMed:10681448, ECO:0000269|PubMed:12925760}.
uniprot
proteins
mass_dalton
68998
uniprot
proteins
mutagenesis
MUTAGEN 223..224; /note="RR->EE: Abolishes binding to phosphatidylinositol 3,4-bisphosphate and phosphatidic acid and the localization to the loose actin filament arrays."; /evidence="ECO:0000269|PubMed:12925760"; MUTAGEN 230; /note="R->C: Reduced binding to phosphatidylinositol 3,4-bisphosphate and reduced association with actin filament."; /evidence="ECO:0000269|PubMed:12925760"; MUTAGEN 297; /note="W->A: Abolishes binding to plasma membrane."; /evidence="ECO:0000269|PubMed:10681448"; MUTAGEN 526..585; /note="Missing: Affects targeting to loose actin filament arrays."; /evidence="ECO:0000269|PubMed:12925760
uniprot
proteins
post_translational_modification
PTM: Tyrosine-phosphorylated. {ECO:0000269|PubMed:10681448}.
uniprot
proteins
pubmed
10681448
uniprot
proteins
pubmed
11726218
uniprot
proteins
pubmed
12925760
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
9734811
uniprot
proteins
sequence_length
585
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10681448}. Cell membrane. Nucleus {ECO:0000269|PubMed:10681448}. Cell projection, lamellipodium {ECO:0000269|PubMed:12925760}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12925760}. Note=In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus (PubMed:10681448). In activated, class-switching B-cells it is associated with membrane IgG but not IgM (PubMed:10681448). Localized to loose actin filament arrays located behind actively extending lamellipodia (PubMed:12925760). {ECO:0000269|PubMed:10681448, ECO:0000269|PubMed:12925760}.
uniprot
proteins