Hs3st1
entrez
15476
canonical
uniprot
O35310
canonical
ensembl
ENSMUSG00000051022
resolver
ensp
ENSMUSP00000051055
resolver
ensp
ENSMUSP00000113919
resolver
enst
ENSMUST00000053116
resolver
enst
ENSMUST00000117944
resolver
genesymbol
Hs3st1
resolver
genesymbol_syn
3ost
resolver
genesymbol_syn
3ost1
resolver
uniprot_entry
HS3S1_MOUSE
resolver
amino_acid_sequence
MTLLLLGAVLLVAQPQLVHSHPAAPGPGLKQQELLRKVIILPEDTGEGTASNGSTQQLPQTIIIGVRKGGTRALLEMLSLHPDVAAAENEVHFFDWEEHYSQGLGWYLTQMPFSSPHQLTVEKTPAYFTSPKVPERIHSMNPTIRLLLILRDPSERVLSDYTQVLYNHLQKHKPYPPIEDLLMRDGRLNLDYKALNRSLYHAHMLNWLRFFPLGHIHIVDGDRLIRDPFPEIQKVERFLKLSPQINASNFYFNKTKGFYCLRDSGKDRCLHESKGRAHPQVDPKLLDKLHEYFHEPNKKFFKLVGRTFDWH
uniprot
proteins
ec_number
2.8.2.23
uniprot
proteins
function
FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan (PubMed:15060080, PubMed:9346953). Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact) (PubMed:15060080, PubMed:9346953). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site (PubMed:15060080, PubMed:9346953). {ECO:0000269|PubMed:15060080, ECO:0000269|PubMed:9346953}.
uniprot
proteins
mass_dalton
35899
uniprot
proteins
mutagenesis
MUTAGEN 67; /note="R->E,A: Abolishes the enzymatic activity."; /evidence="ECO:0000269|PubMed:15060080"; MUTAGEN 68; /note="K->A: Abolishes the enzymatic activity."; /evidence="ECO:0000269|PubMed:15060080"; MUTAGEN 72; /note="R->A,E: Abolishes the enzymatic activity."; /evidence="ECO:0000269|PubMed:15060080"; MUTAGEN 76; /note="E->A,Q: Strongly decreases the enzymatic activity."; /evidence="ECO:0000269|PubMed:15060080"; MUTAGEN 88; /note="E->A: Decreases the enzymatic activity."; /evidence="ECO:0000269|PubMed:15060080"; MUTAGEN 89; /note="N->A,D: Decreases the enzymatic activity."; /evidence="ECO:0000269|PubMed:15060080"; MUTAGEN 90; /note="E->Q,A: Abolishes the enzymatic activity."; /evidence="ECO:0000269|PubMed:15060080"; MUTAGEN 92; /note="H->F,A: Abolishes the enzymatic activity."; /evidence="ECO:0000269|PubMed:15060080"; MUTAGEN 95; /note="D->A,N: Abolishes the enzymatic activity."; /evidence="ECO:0000269|PubMed:15060080"; MUTAGEN 96; /note="W->A,F: Decreases the enzymatic activity."; /evidence="ECO:0000269|PubMed:15060080"; MUTAGEN 98; /note="E->A: Decreases the enzymatic activity."; /evidence="ECO:0000269|PubMed:15060080"; MUTAGEN 123; /note="K->A: Abolishes the enzymatic activity."; /evidence="ECO:0000269|PubMed:15060080"; MUTAGEN 132; /note="K->A: Decreases the enzymatic activity."; /evidence="ECO:0000269|PubMed:15060080"; MUTAGEN 163; /note="Q->A: Strongly decreases the enzymatic activity."; /evidence="ECO:0000269|PubMed:15060080"; MUTAGEN 197; /note="R->A: Weakly decrease the enzymatic activity."; /evidence="ECO:0000269|PubMed:15060080"; MUTAGEN 271; /note="H->A: No effect."; /evidence="ECO:0000269|PubMed:15060080"; MUTAGEN 271; /note="H->F: Decreases the enzymatic activity."; /evidence="ECO:0000269|PubMed:15060080"; MUTAGEN 273; /note="S->A: Weakly decrease the enzymatic activity."; /evidence="ECO:0000269|PubMed:15060080"; MUTAGEN 274; /note="K->A: Strongly decrease the enzymatic activity."; /evidence="ECO:0000269|PubMed:15060080"; MUTAGEN 276; /note="R->A: Abolishes the enzymatic activity."; /evidence="ECO:0000269|PubMed:15060080
uniprot
proteins
protein_family
Sulfotransferase 1 family
uniprot
proteins
pubmed
11006120
uniprot
proteins
pubmed
15060080
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
9346953
uniprot
proteins
sequence_length
311
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus lumen {ECO:0000305}.
uniprot
proteins