Atp8b1
entrez
54670
canonical
uniprot
Q148W0
canonical
ensembl
ENSMUSG00000039529
resolver
ensp
ENSMUSP00000025482
resolver
ensp
ENSMUSP00000306245
resolver
enst
ENSMUST00000025482
resolver
genesymbol
Atp8b1
resolver
uniprot
Q3U010
resolver
uniprot
Q6R964
resolver
uniprot_entry
AT8B1_MOUSE
resolver
uniprot_sec
Q3U010
resolver
uniprot_sec
Q6R964
resolver
amino_acid_sequence
MSTERDSETTFDEESQPNDEVVPYSDDETEDELEDQGSTVEPEQNRVNREAEKKRETFRKDCTWQVKANDRKFHEQPHFMNTKFFCIKESKYASNAIKTYKYNGFTFLPMNLFEQFKRAANFYFLILLILQAIPQISTLAWYTTLVPLLLVLGITAIKDLVDDVARHKMDKEINNRTCEVIKDGRFKIIKWKDIQVGDVIRLKKNDFIPADILLLSSSEPNSLCYVETAELDGETNLKFKMALEITDQYLQIEDNLATFDGFIECEEPNNRLDKFTGTLFWKNQSFPLDADKILLRGCVIRNTDVCHGLVIFAGADTKIMKNSGKTRFKRTKIDYLMNYMVYTIFIVLILVSAGLAIGHAYWEAQVGNYSWYLYDGENATPSYRGFLNFWGYIIVLNTMVPISLYVSVEVIRLGQSHFINWDLQMYYAEKDTPAKARTTTLNEQLGQIHYIFSDKTGTLTQNIMTFKKCCINGTIYGDHRDASQHSHSKIELVDFSWNTFADGKLAFYDHYLIEQIQSGKEPEVRQFFFLLSICHTVMVDRIDGQINYQAASPDEGALVNAARNFGFAFLARTQNTITVSELGSERTYNVLAILDFNSDRKRMSIIVRTPEGSIRLYCKGADTVIYERLHRMNPTKQETQDALDIFASETLRTLCLCYKEIEEKEFTEWNNKFMAASVASSNRDEALDKVYEEIEKDLILLGATAIEDKLQDGVPETISKLAKADIKIWVLTGDKKETAENIGFACELLTEDTTICYGEDINSLLHTRMENQRNRGGVSAKFAPPVYEPFFPPGENRALIITGSWLNEILLEKKTKRSKILKLKFPRTEEERRMRSQSRRRLEEKKEQRQKNFVDLACECSAVICCRVTPKQKAMVVDLVKRYKKAITLAIGDGANDVNMIKTAHIGVGISGQEGMQAVMSSDYSFAQFRYLQRLLLVHGRWSYIRMCKFLRYFFYKNFAFTLVHFWYSFFNGYSAQTAYEDWFITLYNVLYSSLPVLLMGLLDQDVSDKLSLRFPGLYVVGQRDLLFNYKRFFVSLLHGVLTSMVLFFIPLGAYLQTVGQDGEAPSDYQSFAVTVASALVITVNFQIGLDTSYWTFVNAFSIFGSIALYFGIMFDFHSAGIHVLFPSAFQFTGTASNALRQPYIWLTIILTVAVCLLPVVAIRFLSMTIWPSESDKIQKHRKRLKAEEQWKRRQSVFRRGVSSRRSAYAFSHQRGYADLISSGRSIRKKRSPLDAIIADGTAEYRRTVES
uniprot
proteins
ec_number
7.6.2.1
uniprot
proteins
function
FUNCTION: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of phospholipids, in particular phosphatidylcholines (PC), from the outer to the inner leaflet of the plasma membrane (By similarity). May participate in the establishment of the canalicular membrane integrity by ensuring asymmetric distribution of phospholipids in the canicular membrane (PubMed:21820390). Thus may have a role in the regulation of bile acids transport into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both and protect hepatocytes from bile salts (PubMed:14976163, PubMed:20126555, PubMed:21820390). Involved in the microvillus formation in polarized epithelial cells; the function seems to be independent from its flippase activity (By similarity). Participates in correct apical membrane localization of CDC42, CFTR and SLC10A2 (PubMed:26416959). Enables CDC42 clustering at the apical membrane during enterocyte polarization through the interaction between CDC42 polybasic region and negatively charged membrane lipids provided by ATP8B1 (PubMed:26416959). Together with CDC50A is involved in uptake of the synthetic drug alkylphospholipid perifosine (By similarity). Required for the preservation of cochlear hair cells in the inner ear (PubMed:19478059). According PubMed:20852622 is proposed to act as cardiolipin transporter during inflammatory injury; the function is questioned by PubMed:21475228 (PubMed:20852622, PubMed:21475228). {ECO:0000250|UniProtKB:O43520, ECO:0000269|PubMed:14976163, ECO:0000269|PubMed:19478059, ECO:0000269|PubMed:20126555, ECO:0000269|PubMed:20852622, ECO:0000269|PubMed:21475228, ECO:0000269|PubMed:21820390, ECO:0000269|PubMed:26416959}.
uniprot
proteins
mass_dalton
143798
uniprot
proteins
mutagenesis
MUTAGEN 308; /note="G->V: Markly decreased expression, hearing loss associated with degeneration of cochlear hair cells and spiral ganglion cells."; /evidence="ECO:0000269|PubMed:19478059
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type IV subfamily
uniprot
proteins
pubmed
14976163
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19478059
uniprot
proteins
pubmed
20126555
uniprot
proteins
pubmed
20852622
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21475228
uniprot
proteins
pubmed
21820390
uniprot
proteins
pubmed
26416959
uniprot
proteins
pubmed
30018401
uniprot
proteins
sequence_length
1251
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20852622}; Multi-pass membrane protein {ECO:0000269|PubMed:20852622}. Apical cell membrane {ECO:0000269|PubMed:26416959}. Cell projection, stereocilium {ECO:0000269|PubMed:20852622}. Endoplasmic reticulum {ECO:0000250|UniProtKB:O43520}. Golgi apparatus {ECO:0000250|UniProtKB:O43520}. Note=Exit from the endoplasmic reticulum requires the presence of CDC50A or CDC50B. Localizes to apical membranes in epithelial cells. {ECO:0000250|UniProtKB:O43520}.
uniprot
proteins
transmembrane_region
TRANSMEM 122..142; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 145..165; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 340..360; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 386..406; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 953..973; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 983..1003; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1033..1053; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1072..1092; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1095..1115; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1143..1163; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins