COPRS
entrez
55352
canonical
uniprot
Q9NQ92
canonical
ensembl
ENSG00000172301
resolver
ensp
ENSP00000304327
resolver
ensp
ENSP00000367901
resolver
enst
ENST00000302362
resolver
enst
ENST00000378634
resolver
genesymbol
COPRS
resolver
genesymbol_syn
C17orf79
resolver
genesymbol_syn
COPR5
resolver
hgnc
HGNC:28848
resolver
uniprot
A6NP14
resolver
uniprot
E1P656
resolver
uniprot
H9KV77
resolver
uniprot
Q96EF5
resolver
uniprot
Q96P75
resolver
uniprot_entry
COPRS_HUMAN
resolver
uniprot_entry
H9KV77_HUMAN
resolver
uniprot_sec
A6NP14
resolver
uniprot_sec
E1P656
resolver
uniprot_sec
Q96EF5
resolver
uniprot_sec
Q96P75
resolver
amino_acid_sequence
MDLQAAGAQAQGAAEPSRGPPLPSARGAPPSPEAGFATADHSSQERETEKAMDRLARGTQSIPNDSPARGEGTHSEEEGFAMDEEDSDGELNTWELSEGTNCPPKEQPGDLFNEDWDSELKADQGNPYDADDIQESISQELKPWVCCAPQGDMIYDPSWHHPPPLIPYYSKMVFETGQFDDAED
uniprot
proteins
function
FUNCTION: Histone-binding protein required for histone H4 methyltransferase activity of PRMT5. Specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. Specifically interacts with the N-terminus of histone H4 but not with histone H3, suggesting that it acts by promoting the association between histone H4 and PRMT5. Involved in CCNE1 promoter repression. Plays a role in muscle cell differentiation by modulating the recruitment of PRMT5 to the promoter of genes involved in the coordination between cell cycle exit and muscle differentiation (By similarity). {ECO:0000250, ECO:0000269|PubMed:18404153}.
uniprot
proteins
mass_dalton
20066
uniprot
proteins
pubmed
10843809
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
18404153
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
184
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18404153}.
uniprot
proteins