Grm2
entrez
108068
canonical
uniprot
Q14BI2
canonical
ensembl
ENSMUSG00000023192
resolver
ensp
ENSMUSP00000023959
resolver
enst
ENSMUST00000023959
resolver
genesymbol
Grm2
resolver
genesymbol_syn
Gprc1b
resolver
genesymbol_syn
Mglur2
resolver
uniprot_entry
GRM2_MOUSE
resolver
amino_acid_sequence
MESLLRFLALLLLRGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEECGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATLSDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAATQRLNASFTWVASDGWGALESVVAGSERAAEGAITIELASYPISDFASYFQNLDPWNNSRNPWFREFWEERFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTDDEVRFDRFGDGIGRYNIFTYLRAGNGRYRYQKVGYWAEGLTLDTSIIPWASPSAGTLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVAAWLVVEAPGIGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAPRASANLGQGSGSQLVPTVCNGREVVDSTTSSL
uniprot
proteins
function
FUNCTION: Dimeric G protein-coupled receptor which is activated by the excitatory neurotransmitter L-glutamate (By similarity). Plays critical roles in modulating synaptic transmission and neuronal excitability. Upon activation by glutamate, inhibits presynaptic calcium channels, reducing further glutamate release and dampening excitatory signaling (PubMed:7965099). Mechanistically, ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization (By similarity). {ECO:0000250|UniProtKB:Q14416, ECO:0000269|PubMed:18297054, ECO:0000269|PubMed:23129762, ECO:0000269|PubMed:7965099}.
uniprot
proteins
mass_dalton
95887
uniprot
proteins
protein_family
G protein-coupled receptor 3 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15753323
uniprot
proteins
pubmed
18297054
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23129762
uniprot
proteins
pubmed
7965099
uniprot
proteins
pubmed
8662555
uniprot
proteins
sequence_length
872
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Synapse. Cell projection, dendrite.
uniprot
proteins
transmembrane_region
TRANSMEM 569..589; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 605..625; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 634..651; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 680..700; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 727..747; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 761..781; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 799..819; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins