Ptger3
entrez
24929
canonical
uniprot
P34980
canonical
ensembl
ENSRNOG00000010325
resolver
ensp
ENSRNOP00000014034
resolver
ensp
ENSRNOP00000014126
resolver
ensp
ENSRNOP00000102793
resolver
ensp
ENSRNOP00000111877
resolver
enst
ENSRNOT00000014034
resolver
enst
ENSRNOT00000014126
resolver
enst
ENSRNOT00000156665
resolver
enst
ENSRNOT00000171890
resolver
genesymbol
Ptger3
resolver
uniprot
A0A0G2JSK4
resolver
uniprot
A0ABK0LEN7
resolver
uniprot
A0ABK0MA05
resolver
uniprot
G3V7D9
resolver
uniprot
Q63194
resolver
uniprot
Q64376
resolver
uniprot_entry
A0A0G2JSK4_RAT
resolver
uniprot_entry
A0ABK0LEN7_RAT
resolver
uniprot_entry
A0ABK0MA05_RAT
resolver
uniprot_entry
G3V7D9_RAT
resolver
uniprot_entry
PE2R3_RAT
resolver
uniprot_sec
Q63194
resolver
uniprot_sec
Q64376
resolver
amino_acid_sequence
MAGVWAPEHSVEAHSNQSSAADGCGSVSVAFPITMMVTGFVGNALAMLLVVRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDPSGRLCTFFGLTMTVFGLSSLLVASAMAVERALAIRAPHWYASHMKTRATPVLLGVWLSVLAFALLPVLGVGRYSVQWPGTWCFISTGPAGNETDSAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRCRAKAAASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSVEQCKTQMGKEKECNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTNYASSSTSLPCPGSSVLMWSDQLER
uniprot
proteins
function
FUNCTION: Receptor for prostaglandin E2 (PGE2) (PubMed:11006128, PubMed:8393672). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal urine volume and osmolality (By similarity). {ECO:0000250|UniProtKB:P30557, ECO:0000269|PubMed:11006128, ECO:0000269|PubMed:8393672}.; FUNCTION: [Isoform Alpha]: Receptor for prostaglandin E2 (PGE2); ligand binding activates a signaling cascade via G(i) proteins that leads to the inhibition of adenylate cyclase. {ECO:0000269|PubMed:11006128}.; FUNCTION: [Isoform Gamma]: Receptor for prostaglandin E2 (PGE2); ligand binding can activate several distinct signaling cascades, resulting in activation or inhibition of adenylate cyclase. {ECO:0000250|UniProtKB:P30557}.
uniprot
proteins
mass_dalton
39942
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11006128
uniprot
proteins
pubmed
8076679
uniprot
proteins
pubmed
8135830
uniprot
proteins
pubmed
8393672
uniprot
proteins
pubmed
8919306
uniprot
proteins
sequence_length
365
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11006128, ECO:0000269|PubMed:8393672}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 31..55; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 69..89; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 109..130; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 152..173; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 204..229; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 260..283; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 304..325; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins