Cnga3
entrez
12790
canonical
uniprot
Q9JJZ8
canonical
ensembl
ENSMUSG00000026114
resolver
ensp
ENSMUSP00000027288
resolver
ensp
ENSMUSP00000142075
resolver
ensp
ENSMUSP00000142175
resolver
ensp
ENSMUSP00000264660
resolver
ensp
ENSMUSP00000264662
resolver
ensp
ENSMUSP00000264664
resolver
ensp
ENSMUSP00000264665
resolver
enst
ENSMUST00000027288
resolver
enst
ENSMUST00000194195
resolver
enst
ENSMUST00000195272
resolver
genesymbol
Cnga3
resolver
genesymbol_syn
Cng3
resolver
uniprot
A0A0A6YXW9
resolver
uniprot
A0A6H2E2T0
resolver
uniprot
Q8CFV6
resolver
uniprot
Q9WV01
resolver
uniprot_entry
A0A0A6YXW9_MOUSE
resolver
uniprot_entry
A0A6H2E2T0_MOUSE
resolver
uniprot_entry
CNGA3_MOUSE
resolver
uniprot_sec
Q8CFV6
resolver
uniprot_sec
Q9WV01
resolver
amino_acid_sequence
MAKVNTQCSQPSPTQLSIKNADRDLDHVENGLGRVSRLIISIRAWASRHLHDEDQTPDSFLDRFHGSELKEVSTRESNAQPNPGEQKPPDGGEGRKEEPIVVDPSSNIYYRWLTAIALPVFYNWCLLVCRACFDELQSEHLTLWLVLDYSADVLYVLDMLVRARTGFLEQGLMVRDTKRLWKHYTKTLHFKLDILSLIPTDLAYLKLGVNYPELRFNRLLKFSRLFEFFDRTETRTNYPNVFRIGNLVLYTLIIIHWNACIYFAISKFIGFGTDSWVYPNTSKPEYARLSRKYIYSLYWSTLTLTTIGETPPPVKDEEYLFVVIDFLVGILIFATIVGNVGSMISNMNAPRVEFQAKIDSVKQYMQFRKVTKDLETRVIRWFDYLWANRKTVDEKEVLKNLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPDAKRALEEKGRQILMKDNLIDEDLVAARVDTRDVEEKVEYLESSLDILQTRFARLLAEYSASQMKLKQRLTRLESQMNRRCCGFSPDRENSEDASKTD
uniprot
proteins
function
FUNCTION: Pore-forming subunit of the cone cyclic nucleotide-gated channel. Mediates cone photoresponses at bright light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade (By similarity) (PubMed:10377453, PubMed:10662822). Pore-forming subunit of the gustatory cyclic nucleotide-gated channel. In the taste buds, may sense oral extracellular pH and conduct ion currents that modulate the excitability of taste cells (By similarity). Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations (By similarity). {ECO:0000250|UniProtKB:Q16281, ECO:0000250|UniProtKB:Q29441, ECO:0000250|UniProtKB:Q9ER33, ECO:0000269|PubMed:10377453, ECO:0000269|PubMed:10662822}.
uniprot
proteins
mass_dalton
72702
uniprot
proteins
protein_family
CNGA3 subfamily
uniprot
proteins
protein_family
Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family
uniprot
proteins
pubmed
10377453
uniprot
proteins
pubmed
10662822
uniprot
proteins
pubmed
10813773
uniprot
proteins
pubmed
11764791
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
631
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Photoreceptor outer segment membrane {ECO:0000269|PubMed:10813773}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q16281}; Multi-pass membrane protein {ECO:0000255}. Note=Localized in cone outer segment membranes. {ECO:0000269|PubMed:10813773}.
uniprot
proteins
transmembrane_region
TRANSMEM 112..133; /note="Helical; Name=S1"; /evidence="ECO:0000250|UniProtKB:Q16281"; TRANSMEM 140..160; /note="Helical; Name=S2"; /evidence="ECO:0000250|UniProtKB:Q16281"; TRANSMEM 188..207; /note="Helical; Name=S3"; /evidence="ECO:0000250|UniProtKB:Q16281"; TRANSMEM 212..229; /note="Helical; Name=S4"; /evidence="ECO:0000250|UniProtKB:Q16281"; TRANSMEM 240..262; /note="Helical; Name=S5"; /evidence="ECO:0000250|UniProtKB:Q16281"; TRANSMEM 289..319; /note="Helical; Name=P-helix"; /evidence="ECO:0000250|UniProtKB:Q16281"; TRANSMEM 320..344; /note="Helical; Name=S6"; /evidence="ECO:0000250|UniProtKB:Q16281
uniprot
proteins