TEAD3
entrez
7005
canonical
uniprot
Q99594
canonical
ensembl
ENSG00000007866
resolver
ensp
ENSP00000345772
resolver
ensp
ENSP00000492431
resolver
enst
ENST00000338863
resolver
enst
ENST00000639578
resolver
genesymbol
TEAD3
resolver
genesymbol_syn
TEAD5
resolver
genesymbol_syn
TEF5
resolver
hgnc
HGNC:11716
resolver
uniprot
A0A7P0SNI2
resolver
uniprot
O95910
resolver
uniprot
Q5BJG7
resolver
uniprot
Q8N6Y4
resolver
uniprot_entry
A0A7P0SNI2_HUMAN
resolver
uniprot_entry
TEAD3_HUMAN
resolver
uniprot_sec
O95910
resolver
uniprot_sec
Q5BJG7
resolver
uniprot_sec
Q8N6Y4
resolver
amino_acid_sequence
MASNSWNASSSPGEAREDGPEGLDKGLDNDAEGVWSPDIEQSFQEALAIYPPCGRRKIILSDEGKMYGRNELIARYIKLRTGKTRTRKQVSSHIQVLARKKVREYQVGIKAMNLDQVSKDKALQSMASMSSAQIVSASVLQNKFSPPSPLPQAVFSTSSRFWSSPPLLGQQPGPSQDIKPFAQPAYPIQPPLPPTLSSYEPLAPLPSAAASVPVWQDRTIASSRLRLLEYSAFMEVQRDPDTYSKHLFVHIGQTNPAFSDPPLEAVDVRQIYDKFPEKKGGLKELYEKGPPNAFFLVKFWADLNSTIQEGPGAFYGVSSQYSSADSMTISVSTKVCSFGKQVVEKVETEYARLENGRFVYRIHRSPMCEYMINFIHKLKHLPEKYMMNSVLENFTILQVVTSRDSQETLLVIAFVFEVSTSEHGAQHHVYKLVKD
uniprot
proteins
function
FUNCTION: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer. {ECO:0000269|PubMed:18579750, ECO:0000269|PubMed:19324877}.
uniprot
proteins
mass_dalton
48676
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18579750
uniprot
proteins
pubmed
19324877
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
9148898
uniprot
proteins
sequence_length
435
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins