MAP4
entrez
4134
canonical
uniprot
P27816
canonical
ensembl
ENSG00000047849
resolver
ensp
ENSP00000353375
resolver
ensp
ENSP00000379083
resolver
ensp
ENSP00000397414
resolver
ensp
ENSP00000407602
resolver
ensp
ENSP00000507895
resolver
ensp
ENSP00000546318
resolver
ensp
ENSP00000546319
resolver
ensp
ENSP00000546321
resolver
ensp
ENSP00000546322
resolver
ensp
ENSP00000546323
resolver
ensp
ENSP00000546324
resolver
ensp
ENSP00000546326
resolver
ensp
ENSP00000546327
resolver
ensp
ENSP00000546328
resolver
ensp
ENSP00000546329
resolver
ensp
ENSP00000546330
resolver
ensp
ENSP00000546331
resolver
ensp
ENSP00000546332
resolver
ensp
ENSP00000546333
resolver
ensp
ENSP00000546334
resolver
ensp
ENSP00000546335
resolver
ensp
ENSP00000546336
resolver
ensp
ENSP00000546338
resolver
ensp
ENSP00000546339
resolver
ensp
ENSP00000546340
resolver
ensp
ENSP00000546341
resolver
ensp
ENSP00000546343
resolver
ensp
ENSP00000546345
resolver
ensp
ENSP00000546346
resolver
ensp
ENSP00000546350
resolver
ensp
ENSP00000546356
resolver
ensp
ENSP00000546358
resolver
ensp
ENSP00000546362
resolver
ensp
ENSP00000546364
resolver
ensp
ENSP00000546365
resolver
ensp
ENSP00000546367
resolver
ensp
ENSP00000546371
resolver
ensp
ENSP00000546372
resolver
ensp
ENSP00000546373
resolver
ensp
ENSP00000592572
resolver
ensp
ENSP00000592573
resolver
ensp
ENSP00000592577
resolver
ensp
ENSP00000592578
resolver
ensp
ENSP00000592582
resolver
ensp
ENSP00000642393
resolver
ensp
ENSP00000642398
resolver
ensp
ENSP00000642400
resolver
ensp
ENSP00000642403
resolver
ensp
ENSP00000642407
resolver
ensp
ENSP00000642409
resolver
ensp
ENSP00000642411
resolver
ensp
ENSP00000642415
resolver
ensp
ENSP00000642416
resolver
ensp
ENSP00000660116
resolver
ensp
ENSP00000660117
resolver
ensp
ENSP00000660118
resolver
ensp
ENSP00000660119
resolver
ensp
ENSP00000660120
resolver
ensp
ENSP00000660121
resolver
ensp
ENSP00000660122
resolver
ensp
ENSP00000660124
resolver
ensp
ENSP00000660125
resolver
ensp
ENSP00000660126
resolver
ensp
ENSP00000660127
resolver
ensp
ENSP00000660132
resolver
ensp
ENSP00000719999
resolver
ensp
ENSP00000720000
resolver
ensp
ENSP00000755786
resolver
ensp
ENSP00000755789
resolver
ensp
ENSP00000755790
resolver
ensp
ENSP00000755791
resolver
ensp
ENSP00000755792
resolver
ensp
ENSP00000755793
resolver
ensp
ENSP00000755794
resolver
ensp
ENSP00000755796
resolver
ensp
ENSP00000755797
resolver
ensp
ENSP00000755800
resolver
ensp
ENSP00000755802
resolver
ensp
ENSP00000755803
resolver
ensp
ENSP00000755805
resolver
ensp
ENSP00000792045
resolver
enst
ENST00000426837
resolver
enst
ENST00000683076
resolver
genesymbol
MAP4
resolver
hgnc
HGNC:6862
resolver
uniprot
A0A804HKE7
resolver
uniprot
E7EVA0
resolver
uniprot
Q13082
resolver
uniprot
Q59FT2
resolver
uniprot
Q68D74
resolver
uniprot
Q6ZUW9
resolver
uniprot
Q86V26
resolver
uniprot
Q96A76
resolver
uniprot
Q96NS9
resolver
uniprot_entry
A0A804HKE7_HUMAN
resolver
uniprot_entry
E7EVA0_HUMAN
resolver
uniprot_entry
MAP4_HUMAN
resolver
uniprot_sec
Q13082
resolver
uniprot_sec
Q59FT2
resolver
uniprot_sec
Q68D74
resolver
uniprot_sec
Q6ZUW9
resolver
uniprot_sec
Q86V26
resolver
uniprot_sec
Q96A76
resolver
uniprot_sec
Q96NS9
resolver
amino_acid_sequence
MADLSLADALTEPSPDIEGEIKRDFIATLEAEAFDDVVGETVGKTDYIPLLDVDEKTGNSESKKKPCSETSQIEDTPSSKPTLLANGGHGVEGSDTTGSPTEFLEEKMAYQEYPNSQNWPEDTNFCFQPEQVVDPIQTDPFKMYHDDDLADLVFPSSATADTSIFAGQNDPLKDSYGMSPCNTAVVPQGWSVEALNSPHSESFVSPEAVAEPPQPTAVPLELAKEIEMASEERPPAQALEIMMGLKTTDMAPSKETEMALAKDMALATKTEVALAKDMESPTKLDVTLAKDMQPSMESDMALVKDMELPTEKEVALVKDVRWPTETDVSSAKNVVLPTETEVAPAKDVTLLKETERASPIKMDLAPSKDMGPPKENKKETERASPIKMDLAPSKDMGPPKENKIVPAKDLVLLSEIEVAQANDIISSTEISSAEKVALSSETEVALARDMTLPPETNVILTKDKALPLEAEVAPVKDMAQLPETEIAPAKDVAPSTVKEVGLLKDMSPLSETEMALGKDVTPPPETEVVLIKNVCLPPEMEVALTEDQVPALKTEAPLAKDGVLTLANNVTPAKDVPPLSETEATPVPIKDMEIAQTQKGISEDSHLESLQDVGQSAAPTFMISPETVTGTGKKCSLPAEEDSVLEKLGERKPCNSQPSELSSETSGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPLATTQPAKTSTSKAKTQPTSLPKQPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKVGSTENIKHQPGGGRAKVEKKTEAAATTRKPESNAVTKTAGPIASAQKQPAGKVQIVSKKVSYSHIQSKCGSKDNIKHVPGGGNVQIQNKKVDISKVSSKCGSKANIKHKPGGGDVKIESQKLNFKEKAQAKVGSLDNVGHLPAGGAVKTEGGGSEAPLCPGPPAGEEPAISEAAPEAGAPTSASGLNGHPTLSGGGDQREAQTLDSQIQETSI
uniprot
proteins
function
FUNCTION: Non-neuronal microtubule-associated protein. Promotes microtubule assembly. {ECO:0000269|PubMed:10791892, ECO:0000269|PubMed:34782749}.
uniprot
proteins
mass_dalton
121005
uniprot
proteins
mutagenesis
MUTAGEN 696; /note="S->E: No change in microtubule binding; no change in microtubule polymerization activity."; /evidence="ECO:0000269|PubMed:10791892"; MUTAGEN 787; /note="S->E: No change in microtubule binding; reduced microtubule polymerization activity."; /evidence="ECO:0000269|PubMed:10791892
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Phosphorylation on Ser-787 negatively regulates MAP4 activity to promote microtubule assembly. Isoform 3 is phosphorylated on Ser-337 and Ser-338. {ECO:0000250, ECO:0000269|PubMed:10791892}.
uniprot
proteins
pubmed
10791892
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14759258
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16093351
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
1718985
uniprot
proteins
pubmed
17487921
uniprot
proteins
pubmed
17693683
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
1905296
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
29180244
uniprot
proteins
pubmed
34782749
uniprot
proteins
pubmed
7857940
uniprot
proteins
sequence_length
1152
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:34782749}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:29180244}. Note=Recruitment to microtubule is inhibited by microtubules polyglutamylation. {ECO:0000269|PubMed:34782749}.
uniprot
proteins