Ralgds
entrez
29622
canonical
uniprot
Q03386
canonical
ensembl
ENSRNOG00000010219
resolver
ensp
ENSRNOP00000013809
resolver
ensp
ENSRNOP00000074350
resolver
ensp
ENSRNOP00000087735
resolver
ensp
ENSRNOP00000100430
resolver
ensp
ENSRNOP00000111335
resolver
enst
ENSRNOT00000013809
resolver
enst
ENSRNOT00000096803
resolver
enst
ENSRNOT00000164313
resolver
genesymbol
Ralgds
resolver
uniprot
A0A8I6A8C4
resolver
uniprot
A0ABK0M6J0
resolver
uniprot
F1LN84
resolver
uniprot_entry
A0A8I6A8C4_RAT
resolver
uniprot_entry
A0ABK0M6J0_RAT
resolver
uniprot_entry
F1LN84_RAT
resolver
uniprot_entry
GNDS_RAT
resolver
amino_acid_sequence
MVQRMWAEASGPIGGAEPLFPGSRRSRSVWDAVRLEVGVPDSCPVVLHSFTQLDPDLPRLESSTQEIGEELINGVIYSISLRKVQLYPGATKGQRWLGCENESALNLYETCKVRTVKAGTLEKLVEHLVPAFQGSDLSYVTVFLCTYRAFTTTQQVLDLLFKRYGCILPYSSEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDLERRAHLLLAQLEDLEPSEVEPEALSPAPVLSLKPASQLEPAPALLLTPSRAVASTPVREPAPVPVLASSPVVAPASELEPALEPPLDPEPTLAPAPELDPTVSQSLHLEPAPVPAPALEPSWPLPETTENGLCAKPHLLLFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRAKKGKEHLAPTIRATVAQFNNVANCVITTCLGDQSMKASDRARVVEHWIEVARECRVLKNFSSLYAILSALQSNAIHRLKKTWEEVSRGSFRVFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPRRTQRRQKETGVIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIVPEEHFGAWFRAMGRLSEAESYNLSCELEPPSESASNTLRSKKSTAIVKRWERRQAPSTELSTSSSAHSKSCDQLRCSPYLSSGDITDALSVHSAGSSTSDVEEINMSFVPESPDGQEKKFWESASQSSPETSGISSASSSTSSSSASTTPVSTTRTHKRSVSGVCSYSSSLPLYNQQVGDCCIIRVSLDVDNGNMYKSILVTSQDKAPTVIRKAMDKHNLDEDEPEDYELLQIISEDHKLKIPENANVFYAMNSAANYDFILKKRAFTKGAKVKHGASSTLPRMKQKGLRIARGIF
uniprot
proteins
function
FUNCTION: Functions as a guanine nucleotide exchange factor (GEF) activating either RalA or RalB GTPases and plays an important role in intracellular transport. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap. During bacterial clearance, recognizes 'Lys-33'-linked polyubiquitinated TRAF3 and subsequently mediates assembly of the exocyst complex. {ECO:0000250|UniProtKB:Q03385, ECO:0000250|UniProtKB:Q12967}.
uniprot
proteins
mass_dalton
98869
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Tyr-795 by MET blocks HRAS binding. {ECO:0000250|UniProtKB:Q03385}.
uniprot
proteins
pubmed
8094051
uniprot
proteins
pubmed
9253406
uniprot
proteins
sequence_length
895
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q03385}. Nucleus {ECO:0000250|UniProtKB:Q03385}. Note=Localizes mainly in the peripheral region of the cytoplasmic membrane in oocytes and in preimplantation embryos until the 8-cell stage. Between the late 1-cell and the early 2-cell stages, nuclear localization becomes stronger. After the 4-cell stage, not detected in the nucleus. {ECO:0000250|UniProtKB:Q03385}.
uniprot
proteins