Aph1b
entrez
208117
canonical
uniprot
Q8C7N7
canonical
ensembl
ENSMUSG00000032375
resolver
ensp
ENSMUSP00000034934
resolver
ensp
ENSMUSP00000211136
resolver
genesymbol
Aph1b
resolver
uniprot
Q3U3B5
resolver
uniprot
Q8CEC9
resolver
uniprot_entry
APH1B_MOUSE
resolver
uniprot_sec
Q3U3B5
resolver
uniprot_sec
Q8CEC9
resolver
amino_acid_sequence
MTAAVFFGCAFIAFGPALALYVFTIATDPLRVIFLIAGAFFWLVSLLLSSVFWFLVRVITDNRDGPVQNYLLIFGVLLSVCIQELFRLAYYKLLKKASEGLKSINPEETAPSMRLLAYVSGLGFGIMSGVFSFVNTLSNSLGPGTVGIHGDSPQFFLNSAFMTLVVIMLHVFWGVVFFDGCEKNKWYTLLTVLLTHLVVSTQTFLSPYYEVNLVTAYIIMVLMGIWAFYVAGGSCRSLKLCLLCQDKDFLLYNQRSR
uniprot
proteins
function
FUNCTION: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
28703
uniprot
proteins
protein_family
APH-1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
257
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..25; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 32..52; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 66..86; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 115..135; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 160..180; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 186..206; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 213..233; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins