GAB2
entrez
9846
canonical
uniprot
Q9UQC2
canonical
ensembl
ENSG00000033327
resolver
ensp
ENSP00000343959
resolver
ensp
ENSP00000354952
resolver
genesymbol
GAB2
resolver
genesymbol_syn
KIAA0571
resolver
hgnc
HGNC:14458
resolver
uniprot
A2RRM2
resolver
uniprot
A6NEW9
resolver
uniprot
A7MD36
resolver
uniprot
O60317
resolver
uniprot_entry
GAB2_HUMAN
resolver
uniprot_sec
A2RRM2
resolver
uniprot_sec
A6NEW9
resolver
uniprot_sec
A7MD36
resolver
uniprot_sec
O60317
resolver
amino_acid_sequence
MSGGGDVVCTGWLRKSPPEKKLRRYAWKKRWFILRSGRMSGDPDVLEYYKNDHSKKPLRIINLNFCEQVDAGLTFNKKELQDSFVFDIKTSERTFYLVAETEEDMNKWVQSICQICGFNQAEESTDSLRNVSSAGHGPRSSPAELSSSSQHLLRERKSSAPSHSSQPTLFTFEPPVSNHMQPTLSTSAPQEYLYLHQCISRRAENARSASFSQGTRASFLMRSDTAVQKLAQGNGHCVNGISGQVHGFYSLPKPSRHNTEFRDSTYDLPRSLASHGHTKGSLTGSETDNEDVYTFKTPSNTLCREFGDLLVDNMDVPATPLSAYQIPRTFTLDKNHNAMTVATPGDSAIAPPPRPPKPSQAETPRWGSPQQRPPISENSRSVAATIPRRNTLPAMDNSRLHRASSCETYEYPQRGGESAGRSAESMSDGVGSFLPGKMIVGRSDSTNSEDNYVPMNPGSSTLLAMERAGDNSQSVYIPMSPGAHHFDSLGYPSTTLPVHRGPSRGSEIQPPPVNRNLKPDRKAKPTPLDLRNNTVIDELPFKSPITKSWSRANHTFNSSSSQYCRPISTQSITSTDSGDSEENYVPMQNPVSASPVPSGTNSPAPKKSTGSVDYLALDFQPSSPSPHRKPSTSSVTSDEKVDYVQVDKEKTQALQNTMQEWTDVRQSSEPSKGAKL
uniprot
proteins
function
FUNCTION: Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. {ECO:0000269|PubMed:15750601, ECO:0000269|PubMed:19172738}.
uniprot
proteins
mass_dalton
74458
uniprot
proteins
mutagenesis
MUTAGEN 210; /note="S->A,E: Impaired interaction with 14-3-3 proteins and increased EGF-independent cell proliferation; when associated with A-391."; /evidence="ECO:0000269|PubMed:19172738"; MUTAGEN 391; /note="T->A,E: Impaired interaction with 14-3-3 proteins and increased EGF-independent cell proliferation; when associated with A-210."; /evidence="ECO:0000269|PubMed:19172738
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residue(s) by the thrombopoietin receptor (TPOR), stem cell factor receptor (SCFR), and T-cell and B-cell antigen receptors, gp130, IL-2R and IL-3R (By similarity). Phosphorylated upon stimulation of TNFRSF11A/RANK by TNFSF11/RANKL (By similarity). Phosphorylated upon EGF stimulation. Phosphorylated on tyrosine residues by HCK upon IL6 signaling. {ECO:0000250, ECO:0000269|PubMed:15010462, ECO:0000269|PubMed:19172738}.; PTM: Dephosphorylated by PTPN11.
uniprot
proteins
protein_family
GAB family
uniprot
proteins
pubmed
10068651
uniprot
proteins
pubmed
15010462
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15750601
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19172738
uniprot
proteins
pubmed
19523899
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23478294
uniprot
proteins
pubmed
9628581
uniprot
proteins
sequence_length
676
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19172738}. Cell membrane {ECO:0000269|PubMed:19172738}. Membrane raft {ECO:0000250|UniProtKB:Q9Z1S8}.
uniprot
proteins