MAPRE1
entrez
22919
canonical
uniprot
Q15691
canonical
ensembl
ENSG00000101367
resolver
ensp
ENSP00000364721
resolver
ensp
ENSP00000578511
resolver
ensp
ENSP00000578512
resolver
ensp
ENSP00000578513
resolver
ensp
ENSP00000578514
resolver
ensp
ENSP00000578515
resolver
ensp
ENSP00000578516
resolver
ensp
ENSP00000578517
resolver
ensp
ENSP00000578518
resolver
ensp
ENSP00000578519
resolver
ensp
ENSP00000578520
resolver
ensp
ENSP00000578521
resolver
ensp
ENSP00000582334
resolver
ensp
ENSP00000582335
resolver
ensp
ENSP00000582337
resolver
ensp
ENSP00000582338
resolver
ensp
ENSP00000582339
resolver
ensp
ENSP00000582340
resolver
ensp
ENSP00000582341
resolver
ensp
ENSP00000582342
resolver
ensp
ENSP00000582343
resolver
ensp
ENSP00000582344
resolver
ensp
ENSP00000582345
resolver
ensp
ENSP00000582346
resolver
ensp
ENSP00000582347
resolver
ensp
ENSP00000582348
resolver
ensp
ENSP00000582349
resolver
ensp
ENSP00000582350
resolver
ensp
ENSP00000582351
resolver
ensp
ENSP00000582352
resolver
ensp
ENSP00000582353
resolver
ensp
ENSP00000582354
resolver
ensp
ENSP00000582355
resolver
enst
ENST00000375571
resolver
enst
ENST00000908452
resolver
enst
ENST00000908453
resolver
enst
ENST00000908454
resolver
enst
ENST00000908455
resolver
enst
ENST00000908456
resolver
enst
ENST00000908457
resolver
enst
ENST00000908458
resolver
enst
ENST00000908459
resolver
enst
ENST00000908460
resolver
enst
ENST00000908461
resolver
enst
ENST00000908462
resolver
enst
ENST00000912275
resolver
enst
ENST00000912276
resolver
enst
ENST00000912278
resolver
enst
ENST00000912279
resolver
enst
ENST00000912280
resolver
enst
ENST00000912281
resolver
enst
ENST00000912282
resolver
enst
ENST00000912283
resolver
enst
ENST00000912284
resolver
enst
ENST00000912285
resolver
enst
ENST00000912286
resolver
enst
ENST00000912287
resolver
enst
ENST00000912288
resolver
enst
ENST00000912289
resolver
enst
ENST00000912290
resolver
enst
ENST00000912291
resolver
enst
ENST00000912292
resolver
enst
ENST00000912293
resolver
enst
ENST00000912294
resolver
enst
ENST00000912295
resolver
enst
ENST00000912296
resolver
genesymbol
MAPRE1
resolver
hgnc
HGNC:6890
resolver
uniprot
B2R6I7
resolver
uniprot
E1P5M8
resolver
uniprot
Q3KQS8
resolver
uniprot_entry
MARE1_HUMAN
resolver
uniprot_sec
B2R6I7
resolver
uniprot_sec
E1P5M8
resolver
uniprot_sec
Q3KQS8
resolver
amino_acid_sequence
MAVNVYSTSVTSDNLSRHDMLAWINESLQLNLTKIEQLCSGAAYCQFMDMLFPGSIALKKVKFQAKLEHEYIQNFKILQAGFKRMGVDKIIPVDKLVKGKFQDNFEFVQWFKKFFDANYDGKDYDPVAARQGQETAVAPSLVAPALNKPKKPLTSSSAAPQRPISTQRTAAAPKAGPGVVRKNPGVGNGDDEAAELMQQVNVLKLTVEDLEKERDFYFGKLRNIELICQENEGENDPVLQRIVDILYATDEGFVIPDEGGPQEEQEEY
uniprot
proteins
function
FUNCTION: Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:23001180, PubMed:28726242, PubMed:28814570, PubMed:34608293). Recruits other +TIP proteins to microtubules by binding to a conserved Ser-X-Leu-Pro (SXLP) motif in their polypeptide chains (PubMed:19632184, PubMed:36592928). Promotes cytoplasmic microtubule nucleation and elongation (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation (PubMed:12388762, PubMed:34608293). Assists chromosome alignment in metaphase by recruiting the SKA complex to the spindle and stabilizing its interactions with microtubule bundles (K-fibers) (PubMed:27225956, PubMed:36592928). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (PubMed:28726242). Functions downstream of Rho GTPases and DIAPH1 in stable microtubule formation (By similarity). Promotes microtubule-mediated GJA1/CX43 trafficking to cell membranes via its interaction with DSP, thereby facilitating gap junction intracellular communication (PubMed:25225338). May play a role in cell migration (By similarity). {ECO:0000250|UniProtKB:Q61166, ECO:0000269|PubMed:12388762, ECO:0000269|PubMed:16109370, ECO:0000269|PubMed:19632184, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23001180, ECO:0000269|PubMed:25225338, ECO:0000269|PubMed:27225956, ECO:0000269|PubMed:28726242, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:34608293, ECO:0000269|PubMed:36592928}.
uniprot
proteins
mass_dalton
29999
uniprot
proteins
mutagenesis
MUTAGEN 59..60; /note="KK->EE: No effect."; /evidence="ECO:0000269|PubMed:12857735"; MUTAGEN 66; /note="K->R: Abolished crotonylation by KAT5."; /evidence="ECO:0000269|PubMed:34608293"; MUTAGEN 89; /note="K->E: Loss of binding to microtubules."; /evidence="ECO:0000269|PubMed:12857735, ECO:0000305|PubMed:27225956"; MUTAGEN 220; /note="K->R: Abolished acetylation by KAT2B/PCAF, impairing kinetochore-microtubule interactions during mitosis."; /evidence="ECO:0000269|PubMed:23001180
uniprot
proteins
post_translational_modification
PTM: Acetylation at Lys-220 by KAT2B/PCAF promotes dynamic kinetochore-microtubule interactions in early mitosis. {ECO:0000269|PubMed:23001180}.; PTM: Crotonylated by KAT5 during mitosis, promoting astral microtubule plasticity and dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation, thereby ensuring accurate spindle positioning in mitosis (PubMed:34608293). Decrotonylated by HDAC3 (PubMed:34608293). {ECO:0000269|PubMed:34608293}.
uniprot
proteins
protein_family
MAPRE family
uniprot
proteins
pubmed
10188731
uniprot
proteins
pubmed
10226031
uniprot
proteins
pubmed
10644998
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
11943150
uniprot
proteins
pubmed
12388762
uniprot
proteins
pubmed
12857735
uniprot
proteins
pubmed
14514668
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15616574
uniprot
proteins
pubmed
15631994
uniprot
proteins
pubmed
16109370
uniprot
proteins
pubmed
16949363
uniprot
proteins
pubmed
17293347
uniprot
proteins
pubmed
17563362
uniprot
proteins
pubmed
17889670
uniprot
proteins
pubmed
19255245
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19543227
uniprot
proteins
pubmed
19553473
uniprot
proteins
pubmed
19632184
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21303978
uniprot
proteins
pubmed
21646404
uniprot
proteins
pubmed
21820309
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23001180
uniprot
proteins
pubmed
23035123
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23509069
uniprot
proteins
pubmed
23874158
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24706950
uniprot
proteins
pubmed
25217626
uniprot
proteins
pubmed
25225338
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26485573
uniprot
proteins
pubmed
27225956
uniprot
proteins
pubmed
28726242
uniprot
proteins
pubmed
28814570
uniprot
proteins
pubmed
29162697
uniprot
proteins
pubmed
34608293
uniprot
proteins
pubmed
36592928
uniprot
proteins
pubmed
7606712
uniprot
proteins
pubmed
9724749
uniprot
proteins
sequence_length
268
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10188731, ECO:0000269|PubMed:12388762, ECO:0000269|PubMed:21646404, ECO:0000269|PubMed:23001180, ECO:0000269|PubMed:25225338, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:9724749}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:12388762, ECO:0000269|PubMed:14654843}. Golgi apparatus {ECO:0000269|PubMed:25217626}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:23509069, ECO:0000269|PubMed:27225956}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:34608293}. Cell membrane {ECO:0000269|PubMed:25225338}. Note=Associated with the microtubule growing distal tips (PubMed:28814570). In addition to localizing to microtubule plus-ends, also exhibits some localization along the length of the microtubules (PubMed:27225956). Recruitment to the Golgi apparatus requires the presence of PDE4DIP isoform 13/MMG8/SMYLE (PubMed:25217626). {ECO:0000269|PubMed:25217626, ECO:0000269|PubMed:27225956, ECO:0000269|PubMed:28814570}.
uniprot
proteins