Agxt2
entrez
83784
canonical
uniprot
Q64565
canonical
ensembl
ENSRNOG00000017821
resolver
ensembl
ENSRNOG00055026998
resolver
ensembl
ENSRNOG00060020703
resolver
ensp
ENSRNOP00000024035
resolver
ensp
ENSRNOP00055038288
resolver
ensp
ENSRNOP00060029618
resolver
enst
ENSRNOT00000024035
resolver
enst
ENSRNOT00055046650
resolver
enst
ENSRNOT00060035993
resolver
genesymbol
Agxt2
resolver
genesymbol_syn
Agt2
resolver
uniprot
O08616
resolver
uniprot
Q642F1
resolver
uniprot_entry
AGT2_RAT
resolver
uniprot_sec
O08616
resolver
uniprot_sec
Q642F1
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by 5-fluorouracil and 6-fluorouracil (PubMed:10989446). Inhibited by phenylhydrazine, hydroxylamine, l-amino-L-proline, para-chloromercuribenzoate and HgCl2 (PubMed:2123486). {ECO:0000269|PubMed:10989446, ECO:0000269|PubMed:2123486}.
uniprot
proteins
amino_acid_sequence
MSLAWRTLQKAFYLETSLRILQMRPSLSCASRIYVPKLTLHTKHNMPPCDFSPEKYQSLAYNHVLEIHKQHLSPVNTAYFQKPLLLHQGHMEWLFDSEGNRYLDFFSGIVTVGVGHCHPKVTAVAKKQMDRLWHTSSVFFHSPMHEYAERLSALLPEPLKVIFLVNSGSEANDLAMVMARAYSNHTDIISFRGAYHGCSPYTLGLTNVGIYKMKVPSTIACQSTMCPDVFRGPWGGSHCRDSPVQTVRKCSCAPDGCQAKERYIEQFKDTLNTSVATSIAGFFAEPIQGVNGVVQYPKEFLKEAFALVRERGGVCIADEVQTGFGRLGSHFWGFQTHDTMPDIVTMAKGIGNGFPMAAVVTTPEIASSLAKHLHHFSTFGGSPLACAIGSAVLEVIEEENLQRNSQEVGTYMLLKFAKLRDEFDIVGDVRGKGLMVGIEMVQDKISRQPLPKTEVNQIHEDCKDMGLLVGRGGNFSQTFRIAPPMRVTKLEVDFAFEVFRSALTQHMERRAK
uniprot
proteins
ec_number
2.6.1.18
uniprot
proteins
ec_number
2.6.1.40
uniprot
proteins
ec_number
2.6.1.44
uniprot
proteins
function
FUNCTION: Multifunctional aminotransferase with a broad substrate specificity (PubMed:10989446, PubMed:2123486, PubMed:2393662, PubMed:6803844). Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor (PubMed:2123486, PubMed:6803844). Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine (PubMed:10989446, PubMed:2393662, PubMed:6803844). Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate (PubMed:10989446). Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA) (PubMed:2123486). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity). {ECO:0000250|UniProtKB:Q9BYV1, ECO:0000269|PubMed:10989446, ECO:0000269|PubMed:2123486, ECO:0000269|PubMed:2393662, ECO:0000269|PubMed:6803844}.
uniprot
proteins
mass_dalton
57201
uniprot
proteins
protein_family
Class-III pyridoxal-phosphate-dependent aminotransferase family
uniprot
proteins
pubmed
10989446
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2123486
uniprot
proteins
pubmed
2393662
uniprot
proteins
pubmed
6803844
uniprot
proteins
pubmed
7592550
uniprot
proteins
sequence_length
512
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:2123486, ECO:0000269|PubMed:2393662}.
uniprot
proteins