Chrm3
entrez
24260
canonical
uniprot
P08483
canonical
ensembl
ENSRNOG00000049410
resolver
ensembl
ENSRNOG00055006531
resolver
ensembl
ENSRNOG00060015814
resolver
ensembl
ENSRNOG00065020850
resolver
ensp
ENSRNOP00000067435
resolver
ensp
ENSRNOP00000080306
resolver
ensp
ENSRNOP00000086603
resolver
ensp
ENSRNOP00000087869
resolver
ensp
ENSRNOP00000090085
resolver
ensp
ENSRNOP00000090433
resolver
ensp
ENSRNOP00000101226
resolver
ensp
ENSRNOP00000110565
resolver
ensp
ENSRNOP00055008232
resolver
ensp
ENSRNOP00055008233
resolver
ensp
ENSRNOP00055008234
resolver
ensp
ENSRNOP00055008235
resolver
ensp
ENSRNOP00055008236
resolver
ensp
ENSRNOP00055008237
resolver
ensp
ENSRNOP00060021705
resolver
ensp
ENSRNOP00060021708
resolver
ensp
ENSRNOP00060021713
resolver
ensp
ENSRNOP00060021718
resolver
ensp
ENSRNOP00060021723
resolver
ensp
ENSRNOP00060021726
resolver
ensp
ENSRNOP00065028502
resolver
ensp
ENSRNOP00065028505
resolver
ensp
ENSRNOP00065028510
resolver
ensp
ENSRNOP00065028513
resolver
ensp
ENSRNOP00065028519
resolver
enst
ENSRNOT00000075651
resolver
enst
ENSRNOT00000102670
resolver
enst
ENSRNOT00000103154
resolver
enst
ENSRNOT00000107962
resolver
enst
ENSRNOT00000113544
resolver
enst
ENSRNOT00000118676
resolver
enst
ENSRNOT00000143201
resolver
enst
ENSRNOT00000160680
resolver
enst
ENSRNOT00055010622
resolver
enst
ENSRNOT00055010623
resolver
enst
ENSRNOT00055010624
resolver
enst
ENSRNOT00055010625
resolver
enst
ENSRNOT00055010626
resolver
enst
ENSRNOT00055010627
resolver
enst
ENSRNOT00060027067
resolver
enst
ENSRNOT00060027072
resolver
enst
ENSRNOT00060027081
resolver
enst
ENSRNOT00060027087
resolver
enst
ENSRNOT00060027093
resolver
enst
ENSRNOT00060027096
resolver
enst
ENSRNOT00065035392
resolver
enst
ENSRNOT00065035397
resolver
enst
ENSRNOT00065035402
resolver
enst
ENSRNOT00065035405
resolver
enst
ENSRNOT00065035411
resolver
genesymbol
Chrm3
resolver
genesymbol_syn
Chrm-3
resolver
uniprot
Q9QWK9
resolver
uniprot_entry
ACM3_RAT
resolver
uniprot_sec
Q9QWK9
resolver
amino_acid_sequence
MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVTQLGSYNISQETGNFSSNDTSSDPLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGVKRSSRRKYGRCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSSILNSTKLPSSDNLQVSNEDLGTVDVERNAHKLQAQKSMGDGDNCQKDFTKLPIQLESAVDTGKTSDTNSSADKTTATLPLSFKEATLAKRFALKTRSQITKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKTLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
uniprot
proteins
function
FUNCTION: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. {ECO:0000269|PubMed:1527051, ECO:0000269|PubMed:1657592, ECO:0000269|PubMed:22358844}.
uniprot
proteins
mass_dalton
66066
uniprot
proteins
mutagenesis
MUTAGEN 148; /note="Y->A: Decreased affinity for acetylcholine."; /evidence="ECO:0000269|PubMed:1657592"; MUTAGEN 231; /note="T->A: Decreased affinity for acetylcholine."; /evidence="ECO:0000269|PubMed:1657592"; MUTAGEN 234; /note="T->A: Strongly decreased affinity for acetylcholine."; /evidence="ECO:0000269|PubMed:1527051, ECO:0000269|PubMed:1657592"; MUTAGEN 506; /note="Y->F: Decreased affinity for acetylcholine."; /evidence="ECO:0000269|PubMed:1527051, ECO:0000269|PubMed:1657592"; MUTAGEN 529; /note="Y->F: Decreased affinity for acetylcholine."; /evidence="ECO:0000269|PubMed:1657592"; MUTAGEN 533; /note="Y->F: Decreased affinity for acetylcholine."; /evidence="ECO:0000269|PubMed:1657592
uniprot
proteins
protein_family
CHRM3 sub-subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Muscarinic acetylcholine receptor subfamily
uniprot
proteins
pubmed
1527051
uniprot
proteins
pubmed
1657592
uniprot
proteins
pubmed
22358844
uniprot
proteins
pubmed
2380182
uniprot
proteins
pubmed
3037705
uniprot
proteins
pubmed
3120722
uniprot
proteins
pubmed
3272174
uniprot
proteins
pubmed
9972520
uniprot
proteins
sequence_length
589
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1527051}; Multi-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:P20309}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P20309}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with TMEM147 in the endoplasmic reticulum (ER) membrane. TMEM147 impairs its trafficking to the cell membrane leading to its retention in the ER membrane. {ECO:0000250|UniProtKB:P20309}.
uniprot
proteins
transmembrane_region
TRANSMEM 67..90; /note="Helical; Name=1"; TRANSMEM 104..129; /note="Helical; Name=2"; TRANSMEM 142..163; /note="Helical; Name=3"; TRANSMEM 184..205; /note="Helical; Name=4"; TRANSMEM 229..251; /note="Helical; Name=5"; TRANSMEM 491..513; /note="Helical; Name=6"; TRANSMEM 526..545; /note="Helical; Name=7
uniprot
proteins