Tacr2
entrez
21337
canonical
uniprot
P30549
canonical
ensembl
ENSMUSG00000020081
resolver
ensp
ENSMUSP00000020278
resolver
enst
ENSMUST00000020278
resolver
genesymbol
Tacr2
resolver
genesymbol_syn
Tac2r
resolver
uniprot
Q3KP20
resolver
uniprot
Q8BZV9
resolver
uniprot_entry
NK2R_MOUSE
resolver
uniprot_entry
Q3KP20_MOUSE
resolver
uniprot_entry
Q8BZV9_MOUSE
resolver
amino_acid_sequence
MGAHASVTDTNILSGLESNATGVTAFSMPGWQLALWATAYLALVLVAVTGNATVIWIILAHERMRTVTNYFIINLALADLCMAAFNATFNFIYASHNIWYFGSTFCYFQNLFPVTAMFVSIYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAVIWLVALALASPQCFYSTITVDQGATKCVVAWPNDNGGKMLLLYHLVVFVLIYFLPLVVMFAAYSVIGLTLWKRAVPRHQAHGANLRHLQAKKKFVKAMVLVVVTFAICWLPYHLYFILGTFQEDIYYRKFIQQVYLALFWLAMSSTMYNPIIYCCLNHRFRSGFRLAFRCCPWGTPTEEDRLELTHTPSISRRVNRCHTKETLFMTGDMTHSEATNGQVGGPQDGEPAGP
uniprot
proteins
function
FUNCTION: Receptor for the tachykinin substance K (neurokinin A), also able to bind and respond to tachynins substance P and neurokinin B/neuromedin-K (PubMed:1370937). The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P (PubMed:1370937). Substance K binding to its receptor triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C (By similarity). Substance K binding also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP). {ECO:0000250|UniProtKB:P16610, ECO:0000250|UniProtKB:P21452, ECO:0000269|PubMed:1370937}.
uniprot
proteins
mass_dalton
43114
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
1370937
uniprot
proteins
sequence_length
384
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P21452}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 33..56; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 70..90; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 108..129; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 150..170; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 197..218; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 252..272; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 291..310; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins