TSC22D4
entrez
81628
canonical
uniprot
Q9Y3Q8
canonical
ensembl
ENSG00000166925
resolver
ensp
ENSP00000300181
resolver
genesymbol
TSC22D4
resolver
genesymbol_syn
THG1
resolver
genesymbol_syn
THG1-PIT
resolver
hgnc
HGNC:21696
resolver
uniprot
A4D2C3
resolver
uniprot
A8MWR6
resolver
uniprot
B4DKI8
resolver
uniprot
D6W5V9
resolver
uniprot_entry
B4DKI8_HUMAN
resolver
uniprot_entry
T22D4_HUMAN
resolver
uniprot_sec
A4D2C3
resolver
uniprot_sec
A8MWR6
resolver
uniprot_sec
D6W5V9
resolver
amino_acid_sequence
MSGGKKKSSFQITSVTTDYEGPGSPGASDPPTPQPPTGPPPRLPNGEPSPDPGGKGTPRNGSPPPGAPSSRFRVVKLPHGLGEPYRRGRWTCVDVYERDLEPHSFGGLLEGIRGASGGAGGRSLDSRLELASLGLGAPTPPSGLSQGPTSWLRPPPTSPGPQARSFTGGLGQLVVPSKAKAEKPPLSASSPQQRPPEPETGESAGTSRAATPLPSLRVEAEAGGSGARTPPLSRRKAVDMRLRMELGAPEEMGQVPPLDSRPSSPALYFTHDASLVHKSPDPFGAVAAQKFSLAHSMLAISGHLDSDDDSGSGSLVGIDNKIEQAMDLVKSHLMFAVREEVEVLKEQIRELAERNAALEQENGLLRALASPEQLAQLPSSGVPRLGPPAPNGPSV
uniprot
proteins
function
FUNCTION: Binds DNA and acts as a transcriptional repressor (PubMed:10488076). Involved in the regulation of systematic glucose homeostasis and insulin sensitivity, via transcriptional repression of downstream insulin signaling targets such as OBP2A/LCN13 (By similarity). Acts as a negative regulator of lipogenic gene expression in hepatocytes and thereby mediates the control of very low-density lipoprotein release (PubMed:23307490). May play a role in neurite elongation and survival (By similarity). {ECO:0000250|UniProtKB:Q9EQN3, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:23307490}.
uniprot
proteins
mass_dalton
41026
uniprot
proteins
protein_family
TSC-22/Dip/Bun family
uniprot
proteins
pubmed
10488076
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21448135
uniprot
proteins
pubmed
22510880
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23307490
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27827363
uniprot
proteins
sequence_length
395
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9EQN3}. Cytoplasm {ECO:0000250|UniProtKB:Q9EQN3}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9EQN3}. Synapse {ECO:0000250|UniProtKB:Q9EQN3}. Note=Localizes away from the nucleus to neurite processes and synaptic termini as cerebellar granular neurons differentiate (By similarity). Accumulates in the cytoplasm of differentiated Purkinje cells (By similarity). Localized to both the cytoplasm and nucleus in immature cerebellar granular neurons and atrophic Purkinje cells (By similarity). {ECO:0000250|UniProtKB:Q9EQN3}.
uniprot
proteins