Jun
entrez
24516
canonical
uniprot
P17325
canonical
ensembl
ENSRNOG00000026293
resolver
ensembl
ENSRNOG00055007293
resolver
ensembl
ENSRNOG00060014128
resolver
ensembl
ENSRNOG00065018436
resolver
ensp
ENSRNOP00000011732
resolver
ensp
ENSRNOP00000105928
resolver
ensp
ENSRNOP00055009646
resolver
ensp
ENSRNOP00060019273
resolver
ensp
ENSRNOP00065024633
resolver
enst
ENSRNOT00000011731
resolver
enst
ENSRNOT00000142314
resolver
enst
ENSRNOT00055012148
resolver
enst
ENSRNOT00060024157
resolver
enst
ENSRNOT00065030925
resolver
genesymbol
Jun
resolver
genesymbol_syn
Rjg-9
resolver
uniprot_entry
JUN_RAT
resolver
amino_acid_sequence
MTAKMETTFYDDALNASFLQSESGAYGYSNPKILKQSMTLNLADPVGNLKPHLRAKNSDLLTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHSQNTLPSVTSAAQPVSGAGMVAPAVASVAGAGGGGGYSASLHSEPPVYANLSNFNPGALSSGGGAPSYGATGLAFPSQPQQQQQPPQPPHHLPQQIPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
uniprot
proteins
function
FUNCTION: Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' (By similarity). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (By similarity). Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. Involved in activated KRAS-mediated transcriptional activation of USP28. Binds to the USP28 promoter (By similarity). {ECO:0000250|UniProtKB:P05412, ECO:0000250|UniProtKB:P05627}.
uniprot
proteins
mass_dalton
36001
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CaMK4 and PRKDC; phosphorylation enhances the transcriptional activity. Phosphorylated by HIPK3. Phosphorylated by DYRK2 at Ser-246; this primes the protein for subsequent phosphorylation by GSK3B at Thr-242. Phosphorylated at Thr-242, Ser-246 and Ser-252 by GSK3B; phosphorylation reduces its ability to bind DNA. Phosphorylated by PLK3 following hypoxia or UV irradiation, leading to increase DNA-binding activity (By similarity). Phosphorylated by VRK1 (By similarity). {ECO:0000250|UniProtKB:P05412}.; PTM: Ubiquitinated (PubMed:27458189). Ubiquitination by the SCF(FBXW7) is leading to its degradation (By similarity). Ubiquitination takes place following phosphorylation, that promotes interaction with FBXW7 (By similarity). {ECO:0000250|UniProtKB:P05412, ECO:0000269|PubMed:27458189}.; PTM: Acetylated at Lys-271 by EP300. {ECO:0000250|UniProtKB:P05412}.
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
protein_family
Jun subfamily
uniprot
proteins
pubmed
1310930
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20852630
uniprot
proteins
pubmed
2113275
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2507134
uniprot
proteins
pubmed
27458189
uniprot
proteins
pubmed
9154808
uniprot
proteins
sequence_length
334
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P05412}.
uniprot
proteins