MEST
entrez
4232
canonical
uniprot
Q5EB52
canonical
ensembl
ENSG00000106484
resolver
ensp
ENSP00000223215
resolver
ensp
ENSP00000342749
resolver
ensp
ENSP00000376884
resolver
ensp
ENSP00000408933
resolver
ensp
ENSP00000409505
resolver
ensp
ENSP00000657917
resolver
genesymbol
MEST
resolver
genesymbol_syn
PEG1
resolver
hgnc
HGNC:7028
resolver
uniprot
B2R6S1
resolver
uniprot
B4DQW6
resolver
uniprot
O14973
resolver
uniprot
O15007
resolver
uniprot
Q6AI49
resolver
uniprot
Q92571
resolver
uniprot_entry
B4DQW6_HUMAN
resolver
uniprot_entry
MEST_HUMAN
resolver
uniprot_sec
B2R6S1
resolver
uniprot_sec
O14973
resolver
uniprot_sec
O15007
resolver
uniprot_sec
Q6AI49
resolver
uniprot_sec
Q92571
resolver
amino_acid_sequence
MVRRDRLRRMREWWVQVGLLAVPLLAAYLHIPPPQLSPALHSWKSSGKFFTYKGLRIFYQDSVGVVGSPEIVVLLHGFPTSSYDWYKIWEGLTLRFHRVIALDFLGFGFSDKPRPHHYSIFEQASIVEALLRHLGLQNRRINLLSHDYGDIVAQELLYRYKQNRSGRLTIKSLCLSNGGIFPETHRPLLLQKLLKDGGVLSPILTRLMNFFVFSRGLTPVFGPYTRPSESELWDMWAGIRNNDGNLVIDSLLQYINQRKKFRRRWVGALASVTIPIHFIYGPLDPVNPYPEFLELYRKTLPRSTVSILDDHISHYPQLEDPMGFLNAYMGFINSF
uniprot
proteins
ec_number
3.-.-.-
uniprot
proteins
function
FUNCTION: Plays an important role in enabling neurons to transition from bipolar to multipolar shapes, a process essential for their correct migration toward the cortical plate during brain development. This function is likely achieved through the regulation of N-cadherin-dependent cell adhesion and the modulation of Akt and canonical Wnt signaling pathways. Essential for the development and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. Negatively regulates the canonical Wnt signaling pathway during adipogenic differentiation by reducing the glycosylation, maturation, and cell membrane localization of the Wnt coreceptor LRP6. {ECO:0000250|UniProtKB:Q07646}.
uniprot
proteins
mass_dalton
38830
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
pubmed
10631159
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
8884280
uniprot
proteins
pubmed
9158153
uniprot
proteins
pubmed
9192843
uniprot
proteins
sequence_length
335
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q07646}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..33; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 63..83; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 266..286; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins