Plpp2
entrez
50784
canonical
uniprot
Q9DAX2
canonical
ensembl
ENSMUSG00000052151
resolver
ensp
ENSMUSP00000069670
resolver
ensp
ENSMUSP00000133247
resolver
ensp
ENSMUSP00000151683
resolver
enst
ENSMUST00000166804
resolver
enst
ENSMUST00000218241
resolver
genesymbol
Plpp2
resolver
genesymbol_syn
Lpp2
resolver
genesymbol_syn
Ppap2c
resolver
uniprot
A0A1W2P7I9
resolver
uniprot
G3XA61
resolver
uniprot
Q9WUA4
resolver
uniprot_entry
A0A1W2P7I9_MOUSE
resolver
uniprot_entry
G3XA61_MOUSE
resolver
uniprot_entry
PLPP2_MOUSE
resolver
uniprot_sec
Q9WUA4
resolver
activity_regulation
ACTIVITY REGULATION: Magnesium-independent phospholipid phosphatase. Insensitive to N-ethylmaleimide. {ECO:0000250|UniProtKB:O43688}.
uniprot
proteins
amino_acid_sequence
MERRWVFVLLDVLCVLVASLPFIILTLVNAPYKRGFYCGDDSIRYPYRPDTITHGLMAGVIITATVILVSLGEAYLVYTDRLYSRSNFNNYVAAIYKVLGTFLFGAAVSQSLTDLAKYMIGRLRPSFLAVCDPDWSQVNCSGYVQLEVCRGSPANVTEARLSFYSGHSSFGMYCMLFLALYVQARLCWKWARLLRPTVQFFLVAFAIYVGYTRVSDHKHHWSDVLVGLLQGALVACLTVRYVSDFFKSRPPQPCQEDEVPERKPSLSLTLTLGDRP
uniprot
proteins
ec_number
3.1.3.-
uniprot
proteins
ec_number
3.1.3.4
uniprot
proteins
function
FUNCTION: Magnesium-independent phospholipid phosphatase that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P. Has no apparent extracellular phosphatase activity and therefore most probably acts intracellularly. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Through dephosphorylation of these bioactive lipid mediators produces new bioactive compounds and may regulate signal transduction in different cellular processes (By similarity). Indirectly regulates, for instance, cell cycle G1/S phase transition through its phospholipid phosphatase activity (By similarity). {ECO:0000250|UniProtKB:O43688, ECO:0000250|UniProtKB:Q8K593}.
uniprot
proteins
mass_dalton
31193
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; phospholipid metabolism. {ECO:0000250|UniProtKB:O43688}.
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:O43688}.
uniprot
proteins
protein_family
PA-phosphatase related phosphoesterase family
uniprot
proteins
pubmed
10662554
uniprot
proteins
pubmed
10992322
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19656770
uniprot
proteins
sequence_length
276
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:O43688}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:O43688}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:O43688}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O43688}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..25; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 52..72; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 88..108; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 162..182; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 190..210; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 219..239; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins