PARD6A
entrez
50855
canonical
uniprot
Q9NPB6
canonical
ensembl
ENSG00000102981
resolver
ensp
ENSP00000219255
resolver
ensp
ENSP00000392388
resolver
ensp
ENSP00000528757
resolver
ensp
ENSP00000528758
resolver
ensp
ENSP00000528759
resolver
ensp
ENSP00000528760
resolver
ensp
ENSP00000583867
resolver
genesymbol
PARD6A
resolver
genesymbol_syn
PAR6A
resolver
hgnc
HGNC:15943
resolver
uniprot
O14911
resolver
uniprot
Q9NPJ7
resolver
uniprot_entry
PAR6A_HUMAN
resolver
uniprot_sec
O14911
resolver
uniprot_sec
Q9NPJ7
resolver
amino_acid_sequence
MARPQRTPARSPDSIVEVKSKFDAEFRRFALPRASVSGFQEFSRLLRAVHQIPGLDVLLGYTDAHGDLLPLTNDDSLHRALASGPPPLRLLVQKRAEADSSGLAFASNSLQRRKKGLLLRPVAPLRTRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTVKPANQRNNVVRGASGRLTGPPSAGPGPAEPDSDDDSSDLVIENRQPPSSNGLSQGPPCWDLHPGCRHPGTRSSLPSLDDQEQASSGWGSRIRGDGSGFSL
uniprot
proteins
function
FUNCTION: Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in the formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10873802). Regulates centrosome organization and function. Essential for the centrosomal recruitment of key proteins that control centrosomal microtubule organization (PubMed:20719959). {ECO:0000269|PubMed:10873802, ECO:0000269|PubMed:20719959}.
uniprot
proteins
mass_dalton
37388
uniprot
proteins
mutagenesis
MUTAGEN 19; /note="K->A: Loss of interaction with ECT2 and PRKCI."; /evidence="ECO:0000269|PubMed:15590654, ECO:0000269|PubMed:19617897"; MUTAGEN 28; /note="R->A: Slight decrease of interaction with PRKCI. Loss of interaction with PRKCI; when associated with A-89."; /evidence="ECO:0000269|PubMed:15590654"; MUTAGEN 89; /note="R->A: Slight decrease of interaction with PRKCI. Loss of interaction with PRKCI; when associated with A-28."; /evidence="ECO:0000269|PubMed:15590654
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by the TGF-beta receptor. {ECO:0000250|UniProtKB:Q9Z101}.; PTM: Ubiquitinated by the SCF(FBXO31) complex, leading to its proteasomal degradation. {ECO:0000269|PubMed:23469015}.
uniprot
proteins
protein_family
PAR6 family
uniprot
proteins
pubmed
10873802
uniprot
proteins
pubmed
10934474
uniprot
proteins
pubmed
10954424
uniprot
proteins
pubmed
11257119
uniprot
proteins
pubmed
11260256
uniprot
proteins
pubmed
12545177
uniprot
proteins
pubmed
14718572
uniprot
proteins
pubmed
15254234
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15590654
uniprot
proteins
pubmed
15761148
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19617897
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20719959
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23469015
uniprot
proteins
pubmed
9482110
uniprot
proteins
sequence_length
346
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Cell projection, ruffle. Cell junction, tight junction. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:20719959}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20719959}. Note=Colocalizes with GTP-bound CDC42 or RAC1 at membrane ruffles and with PARD3 and PRKCI at epithelial tight junctions. Recruited to the centrosome by a microtubule and dynein-dynactin-dependent mechanism. {ECO:0000269|PubMed:20719959}.
uniprot
proteins