Ephb2
entrez
13844
canonical
uniprot
P54763
canonical
ensembl
ENSMUSG00000028664
resolver
ensp
ENSMUSP00000058135
resolver
ensp
ENSMUSP00000101471
resolver
ensp
ENSMUSP00000101472
resolver
ensp
ENSMUSP00000223098
resolver
genesymbol
Ephb2
resolver
genesymbol_syn
Epth3
resolver
genesymbol_syn
Nuk
resolver
genesymbol_syn
Sek3
resolver
uniprot
A3KG00
resolver
uniprot
A3KG01
resolver
uniprot
A3KG02
resolver
uniprot
A3KG89
resolver
uniprot
A3KG90
resolver
uniprot
Q62213
resolver
uniprot
Q6GTQ7
resolver
uniprot
Q6P5F1
resolver
uniprot
Q9QVY4
resolver
uniprot_entry
EPHB2_MOUSE
resolver
uniprot_sec
A3KG00
resolver
uniprot_sec
A3KG01
resolver
uniprot_sec
A3KG02
resolver
uniprot_sec
A3KG89
resolver
uniprot_sec
A3KG90
resolver
uniprot_sec
Q62213
resolver
uniprot_sec
Q6GTQ7
resolver
uniprot_sec
Q6P5F1
resolver
uniprot_sec
Q9QVY4
resolver
amino_acid_sequence
MAVRRLGAALLLLPLLAAVEETLMDSTTATAELGWMVHPPSGWEEVSGYDENMNTIRTYQVCNVFESSQNNWLRTKFIRRRGAHRIHVEMKFSVRDCSSIPSVPGSCKETFNLYYYEADFDLATKTFPNWMENPWVKVDTIAADESFSQVDLGGRVMKINTEVRSFGPVSRNGFYLAFQDYGGCMSLIAVRVFYRKCPRIIQNGAIFQETLSGAESTSLVAARGSCIANAEEVDVPIKLYCNGDGEWLVPIGRCMCKAGFEAVENGTVCRGCPSGTFKANQGDEACTHCPINSRTTSEGATNCVCRNGYYRADLDPLDMPCTTIPSAPQAVISSVNETSLMLEWTPPRDSGGREDLVYNIICKSCGSGRGACTRCGDNVQYAPRQLGLTEPRIYISDLLAHTQYTFEIQAVNGVTDQSPFSPQFASVNITTNQAAPSAVSIMHQVSRTVDSITLSWSQPDQPNGVILDYELQYYEKELSEYNATAIKSPTNTVTVQGLKAGAIYVFQVRARTVAGYGRYSGKMYFQTMTEAEYQTSIKEKLPLIVGSSAAGLVFLIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAKEIDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKIPIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTLDKMIRNPNSLKAMAPLSSGINLPLLDRTIPDYTSFNTVDEWLEAIKMGQYKESFANAGFTSFDVVSQMMMEDILRVGVTLAGHQKKILNSIQVMRAQMNQIQSVEV
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor. May be involved in the regulation of platelet activation and blood coagulation (By similarity). {ECO:0000250|UniProtKB:P29323, ECO:0000269|PubMed:10839360, ECO:0000269|PubMed:14691139, ECO:0000269|PubMed:15223334, ECO:0000269|PubMed:21029865, ECO:0000269|PubMed:8689685, ECO:0000269|PubMed:8947026, ECO:0000269|PubMed:9990854}.
uniprot
proteins
mass_dalton
109899
uniprot
proteins
mutagenesis
MUTAGEN 596; /note="Y->F: No loss of interaction with SPSB4; when associated with F-602."; /evidence="ECO:0000269|PubMed:28931592"; MUTAGEN 602; /note="Y->F: No loss of interaction with SPSB4; when associated with F-596."; /evidence="ECO:0000269|PubMed:28931592
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated; ligand binding stimulates autophosphorylation on tyrosine residues. {ECO:0000269|PubMed:17428795}.; PTM: Ligand binding induces cleavage by matrix metalloproteinases (MMPs) such as MMP7/MMP9, producing an EphB2/N-terminal fragment (NTF) and a C-terminal long fragment (EphB2-LF). EphB2-LF is further cleaved by MMPs, producing EphB2/CTF1 which is further cleaved by the PS1/gamma-secretase producing EphB2/CTF2. {ECO:0000269|PubMed:17428795}.; PTM: Polyubiquitinated; ligand binding stimulates ubiquitination (PubMed:17428795, PubMed:28931592). Ubiquitinated by RNF186 at Lys-891, mainly through 'Lys-27'-linked polyubiquitin chains (By similarity). Ubiquitinated by CRL2(KLHDC2) E3 ligase complex (By similarity). {ECO:0000250|UniProtKB:P29323, ECO:0000269|PubMed:17428795, ECO:0000269|PubMed:28931592}.
uniprot
proteins
protein_family
Ephrin receptor subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
10542222
uniprot
proteins
pubmed
10704386
uniprot
proteins
pubmed
10839360
uniprot
proteins
pubmed
11780069
uniprot
proteins
pubmed
14691139
uniprot
proteins
pubmed
15107857
uniprot
proteins
pubmed
15223334
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17428795
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
21029865
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27446912
uniprot
proteins
pubmed
28931592
uniprot
proteins
pubmed
7947319
uniprot
proteins
pubmed
8134103
uniprot
proteins
pubmed
8689685
uniprot
proteins
pubmed
8947026
uniprot
proteins
pubmed
9853759
uniprot
proteins
pubmed
9883737
uniprot
proteins
pubmed
9990854
uniprot
proteins
sequence_length
986
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Cell projection, dendrite.
uniprot
proteins
transmembrane_region
TRANSMEM 544..564; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins