MAP3K8
entrez
1326
canonical
uniprot
P41279
canonical
ensembl
ENSG00000107968
resolver
ensp
ENSP00000263056
resolver
ensp
ENSP00000364470
resolver
ensp
ENSP00000443610
resolver
ensp
ENSP00000567752
resolver
ensp
ENSP00000567754
resolver
ensp
ENSP00000589605
resolver
ensp
ENSP00000641404
resolver
genesymbol
MAP3K8
resolver
genesymbol_syn
COT
resolver
genesymbol_syn
ESTF
resolver
hgnc
HGNC:6860
resolver
uniprot
A8K2Q5
resolver
uniprot
D3DRX1
resolver
uniprot
Q14275
resolver
uniprot
Q5T855
resolver
uniprot
Q6FG25
resolver
uniprot
Q9HC81
resolver
uniprot_entry
M3K8_HUMAN
resolver
uniprot_entry
Q6FG25_HUMAN
resolver
uniprot_sec
A8K2Q5
resolver
uniprot_sec
D3DRX1
resolver
uniprot_sec
Q14275
resolver
uniprot_sec
Q5T855
resolver
uniprot_sec
Q9HC81
resolver
amino_acid_sequence
MEYMSTGSDNKEEIDLLIKHLNVSDVIDIMENLYASEEPAVYEPSLMTMCQDSNQNDERSKSLLLSGQEVPWLSSVRYGTVEDLLAFANHISNTAKHFYGQRPQESGILLNMVITPQNGRYQIDSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKHEALNPPREDQPRCQSLDSALLERKRLLSRKELELPENIADSSCTGSTEESEMLKRQRSLYIDLGALAGYFNLVRGPPTLEYG
uniprot
proteins
ec_number
2.7.11.25
uniprot
proteins
function
FUNCTION: Required for lipopolysaccharide (LPS)-induced, TLR4-mediated activation of the MAPK/ERK pathway in macrophages, thus being critical for production of the pro-inflammatory cytokine TNF (TNF) during immune responses. Involved in the regulation of T-helper cell differentiation and IFNG expression in T-cells. Involved in mediating host resistance to bacterial infection through negative regulation of type I interferon (IFN) production. In vitro, activates MAPK/ERK pathway in response to IL1 in an IRAK1-independent manner, leading to up-regulation of IL8 and CCL4. Transduces CD40 and TNFRSF1A signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. May also play a role in the transduction of TNF signals that activate JNK and NF-kappa-B in some cell types. In adipocytes, activates MAPK/ERK pathway in an IKBKB-dependent manner in response to IL1B and TNF, but not insulin, leading to induction of lipolysis. Plays a role in the cell cycle. Isoform 1 shows some transforming activity, although it is much weaker than that of the activated oncogenic variant. {ECO:0000269|PubMed:11342626, ECO:0000269|PubMed:12667451, ECO:0000269|PubMed:15169888, ECO:0000269|PubMed:16371247, ECO:0000269|PubMed:1833717, ECO:0000269|PubMed:19001140, ECO:0000269|PubMed:19808894}.
uniprot
proteins
mass_dalton
52925
uniprot
proteins
mutagenesis
MUTAGEN 290; /note="T->A: Loss of MEK phosphorylation activity and almost abolished autophosphorylation activity. Loss of IL1-stimulated MEK phosphorylation activity but not of IL1-stimulated autophosphorylation activity. No effect on KSR2 binding."; /evidence="ECO:0000269|PubMed:15466476"; MUTAGEN 290; /note="T->D: Impaired MEK phosphorylation and autophosphorylation activities. No effect on KSR2 binding."; /evidence="ECO:0000269|PubMed:15466476"; MUTAGEN 290; /note="T->E: Loss of MEK phosphorylation activity and almost abolished autophosphorylation activity. No effect on KSR2 binding."; /evidence="ECO:0000269|PubMed:15466476
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated (PubMed:1833717, PubMed:8226782). Isoform 1 undergoes phosphorylation mainly on Ser residues, and isoform 2 on both Ser and Thr residues (PubMed:8226782). Phosphorylated on Thr-290; the phosphorylation is necessary but not sufficient for full kinase activity in vitro and for the dissociation of isoform 1 from NFKB1, leading to its degradation (PubMed:15466476, PubMed:15699325). Phosphorylated on Ser-400 by IKBKB; the phosphorylation is required for LPS-stimulated activation of the MAPK/ERK pathway in macrophages (PubMed:17472361, PubMed:22988300). {ECO:0000269|PubMed:15466476, ECO:0000269|PubMed:15699325, ECO:0000269|PubMed:17472361, ECO:0000269|PubMed:1833717, ECO:0000269|PubMed:22988300, ECO:0000269|PubMed:8226782}.
uniprot
proteins
protein_family
MAP kinase kinase kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
pubmed
10896655
uniprot
proteins
pubmed
11342626
uniprot
proteins
pubmed
12667451
uniprot
proteins
pubmed
12975377
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15169888
uniprot
proteins
pubmed
15466476
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15699325
uniprot
proteins
pubmed
16371247
uniprot
proteins
pubmed
17472361
uniprot
proteins
pubmed
1833717
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19001140
uniprot
proteins
pubmed
19754427
uniprot
proteins
pubmed
19808894
uniprot
proteins
pubmed
2072910
uniprot
proteins
pubmed
22988300
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24325551
uniprot
proteins
pubmed
8226782
uniprot
proteins
pubmed
8479752
uniprot
proteins
pubmed
9950430
uniprot
proteins
sequence_length
467
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:1833717, ECO:0000269|PubMed:8226782}.
uniprot
proteins