Cdc5l
entrez
85434
canonical
uniprot
O08837
canonical
ensembl
ENSRNOG00000019975
resolver
ensembl
ENSRNOG00055007576
resolver
ensembl
ENSRNOG00060020516
resolver
ensembl
ENSRNOG00065026122
resolver
ensp
ENSRNOP00000027264
resolver
ensp
ENSRNOP00055010097
resolver
ensp
ENSRNOP00060029449
resolver
ensp
ENSRNOP00065036992
resolver
enst
ENSRNOT00000027264
resolver
enst
ENSRNOT00055012680
resolver
enst
ENSRNOT00060035789
resolver
enst
ENSRNOT00065045110
resolver
genesymbol
Cdc5l
resolver
genesymbol_syn
Pcdc5rp
resolver
uniprot
B1WBQ0
resolver
uniprot_entry
B1WBQ0_RAT
resolver
uniprot_entry
CDC5L_RAT
resolver
amino_acid_sequence
MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEEEKLLHLAKLMPTQWRTIAPIIGRTAAQCLEHYEFLLDKTAQRDNEEETTDDPRKLKPGEIDPNPETKPARPDPIDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLAALQKRRELRAAGIEIQKKRKKKRGVDYNAEIPFEKKPALGFYDTSEENYQALDADFRKLRQQDLDGELRSEKEGRDRKKDKQHLKRKKESDLPSAILQTSGVSEFTKKRSKLVLPAPQISDAELQEVVKVGQASEVARQTAEESGITNSASSTLLSEYNVTNNSIALRTPRTPASQDRILQEAQNLMALTNVDTPLKGGLNTPLHESDFSGVTPQRQVVQTPNTVLSTPFRTPSNGAEGLTPRSGTTPKPVTNATPGRTPLRDKLNINPEDGMADYSDPSYVKQMERESREHLRLGLLGLPAPKNDFEIVLPENAEKELEEREMDDTYIEDAADVDARKQAIRDAERVKEMKRMHKAVQKDLPRPSEVNETILRPLNVEPPLTDLQKSEELIKKEMITMLHYDLLHHPYEPSGNKKGKNVGFATNNSEHITYLEHSPYEKFSKEDLKKAQDVLVQEMEVVKQGMSHGELSSEAYNQVWEECYSQVLYLPAQSRYTRANLASKKDRIESLEKRLEINRGHMTTEAKRAAKMEKKMKILLGGYQSRAMGLLKQLNDLWDQIEQAHLELRTFEELKKHEDSAIPRRLECLKEDVQRQQEREKELQQRYADLLMEKETLQAKF
uniprot
proteins
function
FUNCTION: DNA-binding protein involved in cell cycle control. May act as a transcription activator. Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. The PRP19-CDC5L complex may also play a role in the response to DNA damage (DDR). As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs. {ECO:0000250|UniProtKB:Q99459}.
uniprot
proteins
mass_dalton
92218
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine and threonine residues. Phosphorylation on Thr-411 and Thr-438 is required for CDC5L-mediated mRNA splicing. Has no effect on subcellular location nor on homodimerization. Phosphorylated in vitro by CDK2 (By similarity). Phosphorylation enhances interaction with PPP1R8. {ECO:0000250, ECO:0000269|PubMed:10827081}.
uniprot
proteins
protein_family
CEF1 family
uniprot
proteins
pubmed
10827081
uniprot
proteins
pubmed
11694351
uniprot
proteins
pubmed
11884640
uniprot
proteins
pubmed
16352598
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
802
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000269|PubMed:11694351, ECO:0000269|PubMed:11884640}. Nucleus speckle {ECO:0000255|PROSITE-ProRule:PRU00625}. Cytoplasm {ECO:0000269|PubMed:11694351}. Note=May shuttle between cytoplasm and nucleus. {ECO:0000303|PubMed:11694351}.
uniprot
proteins