CLIC6
entrez
54102
canonical
uniprot
Q96NY7
canonical
ensembl
ENSG00000159212
resolver
ensp
ENSP00000290332
resolver
ensp
ENSP00000353959
resolver
genesymbol
CLIC6
resolver
genesymbol_syn
CLIC1L
resolver
hgnc
HGNC:2065
resolver
uniprot
A8K0U8
resolver
uniprot
Q8IX31
resolver
uniprot_entry
CLIC6_HUMAN
resolver
uniprot_sec
A8K0U8
resolver
uniprot_sec
Q8IX31
resolver
activity_regulation
ACTIVITY REGULATION: Channel activity is redox- and pH-regulated. Inhibited by IAA-94. {ECO:0000269|PubMed:37838179}.
uniprot
proteins
amino_acid_sequence
MAEAAEPEGVAPGPQGPPEVPAPLAERPGEPGAAGGEAEGPEGSEGAEEAPRGAAAVKEAGGGGPDRGPEAEARGTRGAHGETEAEEGAPEGAEVPQGGEETSGAQQVEGASPGRGAQGEPRGEAQREPEDSAAPERQEEAEQRPEVPEGSASGEAGDSVDAEGPLGDNIEAEGPAGDSVEAEGRVGDSVDAEGPAGDSVDAEGPLGDNIQAEGPAGDSVDAEGRVGDSVDAEGPAGDSVDAEGRVGDSVEAGDPAGDGVEAGVPAGDSVEAEGPAGDSMDAEGPAGRARRVSGEPQQSGDGSLSPQAEAIEVAAGESAGRSPGELAWDAAEEAEVPGVKGSEEAAPGDARADAGEDRVGDGPQQEPGEDEERRERSPEGPREEEAAGGEEESPDSSPHGEASRGAAEPEAQLSNHLAEEGPAEGSGEAARVNGRREDGEASEPRALGQEHDITLFVKVKLTALGCSRIAIKKYLRAGYDGESIGNCPFSQRLFMILWLKGVIFNVTTVDLKRKPADLQNLAPGTNPPFMTFDGEVKTDVNKIEEFLEEKLAPPRYPKLGTQHPESNSAGNDVFAKFSAFIKNTKKDANEIHEKNLLKALRKLDNYLNSPLPDEIDAYSTEDVTVSGRKFLDGDELTLADCNLLPKLHIIKIVAKKYRDFEFPSEMTGIWRYLNNAYARDEFTNTCPADQEIEHAYSDVAKRMK
uniprot
proteins
ec_number
1.8.-.-
uniprot
proteins
function
FUNCTION: In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (By similarity). Can insert into membranes and form voltage-dependent chloride-selective channels. The channel opens upon membrane depolarization at positive voltages and closes at negative membrane voltages (PubMed:37838179). May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity). {ECO:0000250|UniProtKB:Q9N2G5, ECO:0000250|UniProtKB:Q9Y696, ECO:0000269|PubMed:37838179}.
uniprot
proteins
mass_dalton
73012
uniprot
proteins
mutagenesis
MUTAGEN 648; /note="H->A: Decreases channel conductance and abolishes its dependence on pH."; /evidence="ECO:0000269|PubMed:37838179
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250|UniProtKB:Q9N2G5}.
uniprot
proteins
protein_family
Chloride channel CLIC family
uniprot
proteins
pubmed
10830953
uniprot
proteins
pubmed
12226712
uniprot
proteins
pubmed
14597386
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
37838179
uniprot
proteins
sequence_length
704
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane (By similarity). {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 489..509; /note="Helical; Note=After insertion into the membrane"; /evidence="ECO:0000255
uniprot
proteins