PFN3
entrez
345456
canonical
uniprot
P60673
canonical
ensembl
ENSG00000196570
resolver
ensp
ENSP00000351379
resolver
enst
ENST00000358571
resolver
genesymbol
PFN3
resolver
hgnc
HGNC:18627
resolver
uniprot
A2RUL3
resolver
uniprot_entry
PROF3_HUMAN
resolver
uniprot_sec
A2RUL3
resolver
amino_acid_sequence
MGDWKVYISAVLRDQRIDDVAIVGHADNSCVWASRPGGLLAAISPQEVGVLTGPDRHTFLQAGLSVGGRRCCVIRDHLLAEGDGVLDARTKGLDARAVCVGRAPRALLVLMGRRGVHGGILNKTVHELIRGLRMQGA
uniprot
proteins
function
FUNCTION: Binds to actin and affects the structure of the cytoskeleton. Slightly reduces actin polymerization. Binds to poly-L-proline, phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtdIns(4)P). May be involved in spermatogenesis. {ECO:0000269|PubMed:19419568}.
uniprot
proteins
mass_dalton
14596
uniprot
proteins
protein_family
Profilin family
uniprot
proteins
pubmed
11867228
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19419568
uniprot
proteins
sequence_length
137
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}.
uniprot
proteins