KRT4
entrez
3851
canonical
uniprot
P19013
canonical
ensembl
ENSG00000170477
resolver
ensp
ENSP00000448220
resolver
enst
ENST00000551956
resolver
genesymbol
KRT4
resolver
genesymbol_syn
CYK4
resolver
hgnc
HGNC:6441
resolver
uniprot
B4DRS2
resolver
uniprot
F8VS64
resolver
uniprot
Q6GTR8
resolver
uniprot
Q96LA7
resolver
uniprot
Q9BTL1
resolver
uniprot_entry
K2C4_HUMAN
resolver
uniprot_sec
B4DRS2
resolver
uniprot_sec
F8VS64
resolver
uniprot_sec
Q6GTR8
resolver
uniprot_sec
Q96LA7
resolver
uniprot_sec
Q9BTL1
resolver
amino_acid_sequence
MIARQQCVRGGPRGFSCGSAIVGGGKRGAFSSVSMSGGAGRCSSGGFGSRSLYNLRGNKSISMSVAGSRQGACFGGAGGFGTGGFGGGFGGSFSGKGGPGFPVCPAGGIQEVTINQSLLTPLHVEIDPEIQKVRTEEREQIKLLNNKFASFIDKVQFLEQQNKVLETKWNLLQQQTTTTSSKNLEPLFETYLSVLRKQLDTLGNDKGRLQSELKTMQDSVEDFKTKYEEEINKRTAAENDFVVLKKDVDAAYLNKVELEAKVDSLNDEINFLKVLYDAELSQMQTHVSDTSVVLSMDNNRNLDLDSIIAEVRAQYEEIAQRSKAEAEALYQTKVQQLQISVDQHGDNLKNTKSEIAELNRMIQRLRAEIENIKKQCQTLQVSVADAEQRGENALKDAHSKRVELEAALQQAKEELARMLREYQELMSVKLALDIEIATYRKLLEGEEYRMSGECQSAVSISVVSGSTSTGGISGGLGSGSGFGLSSGFGSGSGSGFGFGGSVSGSSSSKIISTTTLNKRR
uniprot
proteins
disease_involvement
DISEASE: White sponge nevus 1 (WSN1) [MIM:193900]: A rare disorder characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved. {ECO:0000269|PubMed:10652003, ECO:0000269|PubMed:12828738}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Structural component of intermediate filaments in mucosal stratified squamous epithelia. Forms heteropolymers with the type I keratin KRT13, assembling into keratin intermediate filament networks that provides structural integrity and mechanical stability of the mucosal epithelium. {ECO:0000269|PubMed:10652003}.
uniprot
proteins
mass_dalton
56144
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
10652003
uniprot
proteins
pubmed
12828738
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2452170
uniprot
proteins
pubmed
7684424
uniprot
proteins
sequence_length
520
uniprot
proteins