Rmnd5b
entrez
66089
canonical
uniprot
Q91YQ7
canonical
ensembl
ENSMUSG00000001054
resolver
ensp
ENSMUSP00000001081
resolver
enst
ENSMUST00000001081
resolver
genesymbol
Rmnd5b
resolver
uniprot_entry
RMD5B_MOUSE
resolver
amino_acid_sequence
MEQCACVERELDKVLHKFLTYGQHCEQSLEELLHSVGQLRAELASAALQGTPLSATLSLVMSQCCRKIRDTVQKLASDHKDIHSSVSRVGKAIDRNFDSEICGVVSDAVWDSREKQQQILQMAIVEHLYQQGMLSVAEELCQESTLNVDLDFKQPFLELNRILEALHEQDLGPALEWAVSHRQRLLELNSSLEFKLHRLHFIRLLAGGPEKQLEALSYARHFQPFARLHQREIQVMMGSLVYLRLGLEKSPYCHLLDNSHWAEICETFTRDACSLLGLSVESPLSVSFASGCVALPVLMNIKAVIEQRQCTGVWSHKDELPIEIELGMKCWYHSVFACPILRQQTSDSNPPIKLICGHVISRDALNKLINGGKLKCPYCPMEQNPADGKRIIF
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. Catalytic activity of the complex is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1. {ECO:0000250|UniProtKB:Q96G75}.
uniprot
proteins
mass_dalton
44421
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
393
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q96G75}.
uniprot
proteins