SYNCRIP
entrez
10492
canonical
uniprot
O60506
canonical
ensembl
ENSG00000135316
resolver
ensembl
ENSG00000271793
resolver
ensp
ENSP00000347380
resolver
ensp
ENSP00000358635
resolver
ensp
ENSP00000484577
resolver
ensp
ENSP00000503183
resolver
ensp
ENSP00000503246
resolver
ensp
ENSP00000504086
resolver
ensp
ENSP00000504120
resolver
ensp
ENSP00000504706
resolver
ensp
ENSP00000504816
resolver
ensp
ENSP00000506874
resolver
ensp
ENSP00000507008
resolver
ensp
ENSP00000507581
resolver
ensp
ENSP00000507623
resolver
enst
ENST00000616122
resolver
enst
ENST00000677771
resolver
enst
ENST00000678878
resolver
enst
ENST00000678899
resolver
enst
ENST00000682504
resolver
enst
ENST00000683074
resolver
enst
ENST00000683436
resolver
enst
ENST00000684462
resolver
genesymbol
SYNCRIP
resolver
genesymbol_syn
HNRPQ
resolver
genesymbol_syn
NSAP1
resolver
hgnc
HGNC:16918
resolver
uniprot
A0A7I2V309
resolver
uniprot
A0A7I2YQN2
resolver
uniprot
A0A804HI31
resolver
uniprot
B7Z645
resolver
uniprot
E1P501
resolver
uniprot
E1P502
resolver
uniprot
Q53H05
resolver
uniprot
Q59GL1
resolver
uniprot
Q5TCG2
resolver
uniprot
Q5TCG3
resolver
uniprot
Q8IW78
resolver
uniprot
Q8N599
resolver
uniprot
Q96LC1
resolver
uniprot
Q96LC2
resolver
uniprot
Q9Y583
resolver
uniprot_entry
A0A7I2V309_HUMAN
resolver
uniprot_entry
A0A7I2YQN2_HUMAN
resolver
uniprot_entry
A0A804HI31_HUMAN
resolver
uniprot_entry
B7Z645_HUMAN
resolver
uniprot_entry
HNRPQ_HUMAN
resolver
uniprot_entry
Q59GL1_HUMAN
resolver
uniprot_sec
E1P501
resolver
uniprot_sec
E1P502
resolver
uniprot_sec
Q53H05
resolver
uniprot_sec
Q5TCG2
resolver
uniprot_sec
Q5TCG3
resolver
uniprot_sec
Q8IW78
resolver
uniprot_sec
Q8N599
resolver
uniprot_sec
Q96LC1
resolver
uniprot_sec
Q96LC2
resolver
uniprot_sec
Q9Y583
resolver
amino_acid_sequence
MATEHVNGNGTEEPMDTTSAVIHSENFQTLLDAGLPQKVAEKLDEIYVAGLVAHSDLDERAIEALKEFNEDGALAVLQQFKDSDLSHVQNKSAFLCGVMKTYRQREKQGTKVADSSKGPDEAKIKALLERTGYTLDVTTGQRKYGGPPPDSVYSGQQPSVGTEIFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQILEEFSKVTEGLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEWADPIEDPDPEVMAKVKVLFVRNLANTVTEEILEKAFSQFGKLERVKKLKDYAFIHFDERDGAVKAMEEMNGKDLEGENIEIVFAKPPDQKRKERKAQRQAAKNQMYDDYYYYGPPHMPPPTRGRGRGGRGGYGYPPDYYGYEDYYDYYGYDYHNYRGGYEDPYYGYEDFQVGARGRGGRGARGAAPSRGRGAAPPRGRAGYSQRGGPGSARGVRGARGGAQQQRGRGVRGARGGRGGNVGGKRKADGYNQPDSKRRQTNNQNWGSQPIAQQPLQGGDHSGNYGYKSENQEFYQDTFGQQWK
uniprot
proteins
function
FUNCTION: Heterogeneous nuclear ribonucleoprotein (hnRNP) implicated in mRNA processing mechanisms. Component of the CRD-mediated complex that promotes MYC mRNA stability. Isoform 1, isoform 2 and isoform 3 are associated in vitro with pre-mRNA, splicing intermediates and mature mRNA protein complexes. Isoform 1 binds to apoB mRNA AU-rich sequences. Isoform 1 is part of the APOB mRNA editosome complex and may modulate the postranscriptional C to U RNA-editing of the APOB mRNA through either by binding to A1CF (APOBEC1 complementation factor), to APOBEC1 or to RNA itself. May be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Interacts in vitro preferentially with poly(A) and poly(U) RNA sequences. Isoform 3 may be involved in cytoplasmic vesicle-based mRNA transport through interaction with synaptotagmins. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation; does not seem to be essential for GAIT complex function. {ECO:0000269|PubMed:11051545, ECO:0000269|PubMed:11134005, ECO:0000269|PubMed:11352648, ECO:0000269|PubMed:11574476, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:23071094}.
uniprot
proteins
mass_dalton
69603
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine. The membrane-bound form found in microsomes is phosphorylated in vitro by insulin receptor tyrosine kinase (INSR). Phosphorylation is inhibited upon binding to RNA, whereas the cytoplasmic form is poorly phosphorylated (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
11051545
uniprot
proteins
pubmed
11134005
uniprot
proteins
pubmed
11352648
uniprot
proteins
pubmed
11574476
uniprot
proteins
pubmed
11991638
uniprot
proteins
pubmed
12376575
uniprot
proteins
pubmed
12601080
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15479637
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16765914
uniprot
proteins
pubmed
17289661
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
19029303
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19523114
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19647514
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21515746
uniprot
proteins
pubmed
23071094
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23455924
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
35538151
uniprot
proteins
pubmed
9731529
uniprot
proteins
pubmed
9847309
uniprot
proteins
sequence_length
623
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11574476, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:19029303, ECO:0000269|PubMed:35538151}. Microsome {ECO:0000250|UniProtKB:Q7TMK9}. Endoplasmic reticulum {ECO:0000250}. Nucleus {ECO:0000250|UniProtKB:Q7TMK9}. Note=The tyrosine phosphorylated form bound to RNA is found in microsomes (By similarity). Localized in cytoplasmic mRNP granules containing untranslated mRNAs (By similarity). {ECO:0000250|UniProtKB:O43390, ECO:0000250|UniProtKB:Q7TMK9}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q7TMK9}. Note=Expressed predominantly in the nucleoplasm. {ECO:0000250|UniProtKB:Q7TMK9}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q7TMK9}. Note=Expressed predominantly in the nucleoplasm. {ECO:0000250|UniProtKB:Q7TMK9}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q7TMK9}. Note=Expressed predominantly in the nucleoplasm. {ECO:0000250|UniProtKB:Q7TMK9}.
uniprot
proteins