IARS
entrez
3376
canonical
uniprot
P41252
canonical
ensembl
ENSG00000196305
resolver
ensembl
ENSG00000291356
resolver
ensp
ENSP00000364794
resolver
ensp
ENSP00000406448
resolver
ensp
ENSP00000415020
resolver
ensp
ENSP00000506798
resolver
ensp
ENSP00000507144
resolver
ensp
ENSP00000507286
resolver
ensp
ENSP00000507577
resolver
ensp
ENSP00000508205
resolver
ensp
ENSP00000516807
resolver
ensp
ENSP00000516808
resolver
ensp
ENSP00000516810
resolver
ensp
ENSP00000516815
resolver
ensp
ENSP00000516819
resolver
ensp
ENSP00000516824
resolver
ensp
ENSP00000579375
resolver
ensp
ENSP00000579376
resolver
ensp
ENSP00000579377
resolver
ensp
ENSP00000579379
resolver
ensp
ENSP00000605970
resolver
ensp
ENSP00000605971
resolver
ensp
ENSP00000691963
resolver
ensp
ENSP00000750708
resolver
enst
ENST00000375643
resolver
enst
ENST00000443024
resolver
enst
ENST00000683469
resolver
enst
ENST00000683565
resolver
enst
ENST00000683679
resolver
enst
ENST00000684557
resolver
enst
ENST00000707248
resolver
enst
ENST00000707249
resolver
enst
ENST00000707251
resolver
enst
ENST00000707263
resolver
enst
ENST00000707274
resolver
enst
ENST00000707281
resolver
enst
ENST00000909316
resolver
enst
ENST00000909317
resolver
enst
ENST00000909320
resolver
enst
ENST00000935912
resolver
genesymbol
IARS
resolver
genesymbol
IARS1
resolver
genesymbol_syn
IARS
resolver
hgnc
HGNC:5330
resolver
uniprot
A0A804HJN6
resolver
uniprot
A0A804HL54
resolver
uniprot
A8KAE9
resolver
uniprot
Q5TCD0
resolver
uniprot
Q6P0M4
resolver
uniprot
Q7L4K8
resolver
uniprot
Q7Z3T4
resolver
uniprot
Q9H588
resolver
uniprot_entry
A0A804HJN6_HUMAN
resolver
uniprot_entry
A0A804HL54_HUMAN
resolver
uniprot_entry
Q6P0M4_HUMAN
resolver
uniprot_entry
Q7L4K8_HUMAN
resolver
uniprot_entry
SYIC_HUMAN
resolver
uniprot_sec
A8KAE9
resolver
uniprot_sec
Q5TCD0
resolver
uniprot_sec
Q7Z3T4
resolver
uniprot_sec
Q9H588
resolver
amino_acid_sequence
MLQQVPENINFPAEEEKILEFWTEFNCFQECLKQSKHKPKFTFYDGPPFATGLPHYGHILAGTIKDIVTRYAHQSGFHVDRRFGWDCHGLPVEYEIDKTLGIRGPEDVAKMGITEYNNQCRAIVMRYSAEWKSTVSRLGRWIDFDNDYKTLYPQFMESVWWVFKQLYDKGLVYRGVKVMPFSTACNTPLSNFESHQNYKDVQDPSVFVTFPLEEDETVSLVAWTTTPWTLPSNLAVCVNPEMQYVKIKDVARGRLLILMEARLSALYKLESDYEILERFPGAYLKGKKYRPLFDYFLKCKENGAFTVLVDNYVKEEEGTGVVHQAPYFGAEDYRVCMDFNIIRKDSLPVCPVDASGCFTTEVTDFAGQYVKDADKSIIRTLKEQGRLLVATTFTHSYPFCWRSDTPLIYKAVPSWFVRVENMVDQLLRNNDLCYWVPELVREKRFGNWLKDARDWTISRNRYWGTPIPLWVSDDFEEVVCIGSVAELEELSGAKISDLHRESVDHLTIPSRCGKGSLHRISEVFDCWFESGSMPYAQVHYPFENKREFEDAFPADFIAEGIDQTRGWFYTLLVLATALFGQPPFKNVIVNGLVLASDGQKMSKRKKNYPDPVSIIQKYGADALRLYLINSPVVRAENLRFKEEGVRDVLKDVLLPWYNAYRFLIQNVLRLQKEEEIEFLYNENTVRESPNITDRWILSFMQSLIGFFETEMAAYRLYTVVPRLVKFVDILTNWYVRMNRRRLKGENGMEDCVMALETLFSVLLSLCRLMAPYTPFLTELMYQNLKVLIDPVSVQDKDTLSIHYLMLPRVREELIDKKTESAVSQMQSVIELGRVIRDRKTIPIKYPLKEIVVIHQDPEALKDIKSLEKYIIEELNVRKVTLSTDKNKYGIRLRAEPDHMVLGKRLKGAFKAVMTSIKQLSSEELEQFQKTGTIVVEGHELHDEDIRLMYTFDQATGGTAQFEAHSDAQALVLLDVTPDQSMVDEGMAREVINRIQKLRKKCNLVPTDEITVYYKAKSEGTYLNSVIESHTEFIFTTIKAPLKPYPVSPSDKVLIQEKTQLKGSELEITLTRGSSLPGPACAYVNLNICANGSEQGGVLLLENPKGDNRLDLLKLKSVVTSIFGVKNTELAVFHDETEIQNQTDLLSLSGKTLCVTAGSAPSLINSSSTLLCQYINLQLLNAKPQECLMGTVGTLLLENPLGQNGLTHQGLLYEAAKVFGLRSRKLKLFLNETQTQEITEDIPVKTLNMKTVYVSVLPTTADF
uniprot
proteins
disease_involvement
DISEASE: Growth retardation, impaired intellectual development, hypotonia, and hepatopathy (GRIDHH) [MIM:617093]: An autosomal recessive disorder characterized by severe growth retardation with prenatal onset, intellectual disability, muscular hypotonia, and hepatic dysfunction. {ECO:0000269|PubMed:27426735}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
6.1.1.5
uniprot
proteins
function
FUNCTION: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. {ECO:0000269|PubMed:8052601}.
uniprot
proteins
mass_dalton
144498
uniprot
proteins
protein_family
Class-I aminoacyl-tRNA synthetase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19131329
uniprot
proteins
pubmed
19289464
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24706940
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27426735
uniprot
proteins
pubmed
7721108
uniprot
proteins
pubmed
8052601
uniprot
proteins
sequence_length
1262
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:27426735, ECO:0000269|PubMed:7721108}. Cytoplasm, cytosol {ECO:0000269|PubMed:19289464}.
uniprot
proteins