Pip4k2c
entrez
117150
canonical
uniprot
Q91XU3
canonical
ensembl
ENSMUSG00000025417
resolver
ensp
ENSMUSP00000013970
resolver
ensp
ENSMUSP00000161111
resolver
enst
ENSMUST00000013970
resolver
genesymbol
Pip4k2c
resolver
genesymbol_syn
Pip5k2c
resolver
uniprot
Q3UFU5
resolver
uniprot
Q99K02
resolver
uniprot_entry
PI42C_MOUSE
resolver
uniprot_sec
Q3UFU5
resolver
uniprot_sec
Q99K02
resolver
amino_acid_sequence
MASSSVPPATAPAAAGGPGPGFGFASKTKKKHFVQQKVKVFRAADPLVGVFLWGVAHSINELSQVPPPVMLLPDDFKASSKIKVNNHFFHRENLPSHFKFKEYCPQVFRNLRDRFAIDDHDYLVSLTRSPPSETEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVENEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKVFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEGPVREEESEWDGDCNLAGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGAEISTVHPEQYAKRFLDFIANIFA
uniprot
proteins
ec_number
2.7.1.149
uniprot
proteins
function
FUNCTION: Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3. {ECO:0000250|UniProtKB:Q8TBX8}.
uniprot
proteins
mass_dalton
47336
uniprot
proteins
post_translational_modification
PTM: Phosphorylated, phosphorylation is induced by EGF. {ECO:0000250|UniProtKB:O88370}.
uniprot
proteins
pubmed
15018809
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
421
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:O88370}. Cytoplasm {ECO:0000250|UniProtKB:O88370}.
uniprot
proteins