Abhd2
entrez
54608
canonical
uniprot
Q9QXM0
canonical
ensembl
ENSMUSG00000039202
resolver
ensp
ENSMUSP00000038361
resolver
ensp
ENSMUSP00000165174
resolver
enst
ENSMUST00000037315
resolver
genesymbol
Abhd2
resolver
genesymbol_syn
Labh-2
resolver
genesymbol_syn
Labh2
resolver
uniprot
Q3U5E8
resolver
uniprot
Q5FWC6
resolver
uniprot
Q9D7Y8
resolver
uniprot_entry
ABHD2_MOUSE
resolver
uniprot_sec
Q3U5E8
resolver
uniprot_sec
Q5FWC6
resolver
uniprot_sec
Q9D7Y8
resolver
activity_regulation
ACTIVITY REGULATION: Acylglycerol lipase activity is activated upon binding to progesterone. {ECO:0000250|UniProtKB:P08910}.
uniprot
proteins
amino_acid_sequence
MNAMLETPELPAVFDGVKLAAVAAVLYVIVRCLNLKSPTAPPDLYFQDSGLSRFLLKSCPLLTKEYIPPLIWGKSGHIQTALYGKMGRVRSPHPYGHRKFITMSDGATSTFDLFEPLAEHCVGDDITMVICPGIANHSEKQYIRTFVDYAQKNGYRCAVLNHLGALPNIELTSPRMFTYGCTWEFGAMVNYIKRTYPQTQLVVVGFSLGGNIVCKYLGETQANQEKVLCCVSVCQGYSALRAQETFMQWDQCRRFYNFLMADNMKKIILSHRQALFGDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKFHGYNSLKEYYEEESCMRYLHRIYVPLMLVNAADDPLVHESLLTIPKSLSEKRENVMFVLPLHGGHLGFFEGSVLFPEPLTWMDKLVVEYANAICQWERNKSQCSDTEQMEAELE
uniprot
proteins
ec_number
3.1.1.23
uniprot
proteins
ec_number
3.1.1.6
uniprot
proteins
ec_number
3.1.1.79
uniprot
proteins
function
FUNCTION: Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (By similarity). Involved in acrosomal reaction (Probable). May also play a role in smooth muscle cells migration (PubMed:15721306). {ECO:0000250|UniProtKB:P08910, ECO:0000269|PubMed:15721306, ECO:0000305|PubMed:26989199}.
uniprot
proteins
mass_dalton
48378
uniprot
proteins
protein_family
AB hydrolase 4 family
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
pubmed
11922611
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15721306
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19250629
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26989199
uniprot
proteins
sequence_length
425
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P08910}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P08910}. Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000269|PubMed:26989199}. Note=Absent from the sperm flagellum. {ECO:0000269|PubMed:26989199}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..30; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins