CLEC4C
entrez
170482
canonical
uniprot
Q8WTT0
canonical
ensembl
ENSG00000198178
resolver
ensp
ENSP00000353500
resolver
ensp
ENSP00000440428
resolver
ensp
ENSP00000445338
resolver
genesymbol
CLEC4C
resolver
genesymbol_syn
BDCA2
resolver
genesymbol_syn
CLECSF11
resolver
genesymbol_syn
CLECSF7
resolver
genesymbol_syn
DLEC
resolver
genesymbol_syn
HECL
resolver
hgnc
HGNC:13258
resolver
uniprot
D3DUU3
resolver
uniprot
Q3T1C3
resolver
uniprot
Q6UXS8
resolver
uniprot
Q8WXX8
resolver
uniprot_entry
CLC4C_HUMAN
resolver
uniprot_sec
D3DUU3
resolver
uniprot_sec
Q3T1C3
resolver
uniprot_sec
Q6UXS8
resolver
uniprot_sec
Q8WXX8
resolver
amino_acid_sequence
MVPEEEPQDREKGLWWFQLKVWSMAVVSILLLSVCFTVSSVVPHNFMYSKTVKRLSKLREYQQYHPSLTCVMEGKDIEDWSCCPTPWTSFQSSCYFISTGMQSWTKSQKNCSVMGADLVVINTREEQDFIIQNLKRNSSYFLGLSDPGGRRHWQWVDQTPYNENVTFWHSGEPNNLDERCAIINFRSSEEWGWNDIHCHVPQKSICKMKKIYI
uniprot
proteins
function
FUNCTION: Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells (PubMed:11748283, PubMed:21880719, PubMed:25995448). Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man (PubMed:21880719, PubMed:25995448). Binds to serum IgG (PubMed:25995448). Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells (PubMed:11748283). May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells (PubMed:11748283, PubMed:21880719). May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium (PubMed:11748283). {ECO:0000269|PubMed:11748283, ECO:0000269|PubMed:21880719, ECO:0000269|PubMed:25995448}.
uniprot
proteins
mass_dalton
25038
uniprot
proteins
mutagenesis
MUTAGEN 139; /note="S->A: Significantly impairs carbohydrate binding for the trisaccharide Gal(beta1-3/4)GlcNAc(beta1-2)Man."; /evidence="ECO:0000269|PubMed:25995448"; MUTAGEN 184; /note="N->A: Abolishes carbohydrate binding for the trisaccharide Gal(beta1-3/4)GlcNAc(beta1-2)Man."; /evidence="ECO:0000269|PubMed:25995448"; MUTAGEN 186; /note="R->A: Significantly impairs carbohydrate binding for the trisaccharide Gal(beta1-3/4)GlcNAc(beta1-2)Man."; /evidence="ECO:0000269|PubMed:25995448"; MUTAGEN 200; /note="V->A: Significantly impairs carbohydrate binding for the trisaccharide Gal(beta1-3/4)GlcNAc(beta1-2)Man."; /evidence="ECO:0000269|PubMed:25995448"; MUTAGEN 202; /note="Q->A: Significantly impairs carbohydrate binding for the trisaccharide Gal(beta1-3/4)GlcNAc(beta1-2)Man."; /evidence="ECO:0000269|PubMed:25995448
uniprot
proteins
pubmed
11031109
uniprot
proteins
pubmed
11536172
uniprot
proteins
pubmed
11748283
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21880719
uniprot
proteins
pubmed
24425442
uniprot
proteins
pubmed
25995448
uniprot
proteins
sequence_length
213
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11748283, ECO:0000269|PubMed:21880719}; Single-pass type II membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..44; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins