Fzd5
entrez
317674
canonical
uniprot
Q8CHL0
canonical
ensembl
ENSRNOG00000014678
resolver
ensp
ENSRNOP00000070441
resolver
ensp
ENSRNOP00000099774
resolver
ensp
ENSRNOP00000107193
resolver
enst
ENSRNOT00000019698
resolver
enst
ENSRNOT00000143661
resolver
enst
ENSRNOT00000154504
resolver
genesymbol
Fzd5
resolver
uniprot
A0A0G2JXX8
resolver
uniprot_entry
A0A0G2JXX8_RAT
resolver
uniprot_entry
FZD5_RAT
resolver
amino_acid_sequence
MARPDPSAPPSLLLLLLAQLVGRAAAASKAPVCQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIHCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGGDAEVLCMDYNRSEATTASPKSFPAKPTLPGPPGAPSSGGECPSGGPSVCTCREPFVPILKESHPLYNKVRTGQVPNCAVPCYQPSFSPDERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACYLCVSLGFLVRLVVGHASVACSREHSHIHYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGVCYVGNQNLNSLRGFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTLLYTVPASIVVACYLYEQHYRESWEAALTCACPGSDAGQPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTLESWRRFTSRCCCSSRRGHKSGGAMVAGDYAEASAALTGRTGPPGPAAAYHKQVSLSHV
uniprot
proteins
function
FUNCTION: Receptor for Wnt proteins (PubMed:20530549). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:20530549). In vitro activates WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 signaling (By similarity). In neurons, activation by WNT7A promotes formation of synapses (PubMed:20530549). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (By similarity). Plays a role in ocular development (By similarity). {ECO:0000250|UniProtKB:Q13467, ECO:0000250|UniProtKB:Q9EQD0, ECO:0000269|PubMed:20530549}.
uniprot
proteins
mass_dalton
64112
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by RNF43 and ZNRF3, leading to its degradation by the proteasome. {ECO:0000250|UniProtKB:Q13467}.
uniprot
proteins
protein_family
G protein-coupled receptor Fz/Smo family
uniprot
proteins
pubmed
20530549
uniprot
proteins
sequence_length
585
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20530549}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q9EQD0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9EQD0}. Synapse {ECO:0000269|PubMed:20530549}. Perikaryon {ECO:0000269|PubMed:20530549}. Cell projection, dendrite {ECO:0000269|PubMed:20530549}. Cell projection, axon {ECO:0000269|PubMed:20530549}. Note=Localized at the plasma membrane and also found at the Golgi apparatus. {ECO:0000250|UniProtKB:Q9EQD0}.
uniprot
proteins
transmembrane_region
TRANSMEM 239..259; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 271..291; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 316..336; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 359..379; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 403..423; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 450..470; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 501..521; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins