AKAP5
entrez
9495
canonical
uniprot
P24588
canonical
ensembl
ENSG00000179841
resolver
ensp
ENSP00000315615
resolver
ensp
ENSP00000378207
resolver
enst
ENST00000320636
resolver
enst
ENST00000394718
resolver
genesymbol
AKAP5
resolver
genesymbol_syn
AKAP79
resolver
hgnc
HGNC:375
resolver
uniprot
A2RRB8
resolver
uniprot
Q6PG46
resolver
uniprot_entry
AKAP5_HUMAN
resolver
uniprot_entry
Q6PG46_HUMAN
resolver
uniprot_sec
A2RRB8
resolver
amino_acid_sequence
METTISEIHVENKDEKRSAEGSPGAERQKEKASMLCFKRRKKAAKALKPKAGSEAADVARKCPQEAGASDQPEPTRGAWASLKRLVTRRKRSESSKQQKPLEGEMQPAINAEDADLSKKKAKSRLKIPCIKFPRGPKRSNHSKIIEDSDCSIKVQEEAEILDIQTQTPLNDQATKAKSTQDLSEGISRKDGDEVCESNVSNSTTSGEKVISVELGLDNGHSAIQTGTLILEEIETIKEKQDVQPQQASPLETSETDHQQPVLSDVPPLPAIPDQQIVEEASNSTLESAPNGKDYESTEIVAEETKPKDTELSQESDFKENGITEEKSKSEESKRMEPIAIIITDTEISEFDVTKSKNVPKQFLISAENEQVGVFANDNGFEDRTSEQYETLLIETASSLVKNAIQLSIEQLVNEMASDDNKINNLLQ
uniprot
proteins
function
FUNCTION: Multivalent scaffold protein that anchors the cAMP-dependent protein kinase/PKA to cytoskeletal and/or organelle-associated proteins, targeting the signal carried by cAMP to specific intracellular effectors (PubMed:1512224). Association with the beta2-adrenergic receptor (beta2-AR) not only regulates beta2-AR signaling pathway, but also the activation by PKA by switching off the beta2-AR signaling cascade. Plays a role in long term synaptic potentiation by regulating protein trafficking from the dendritic recycling endosomes to the plasma membrane and controlling both structural and functional plasticity at excitatory synapses (PubMed:25589740). In hippocampal pyramidal neurons, recruits KCNK2/TREK-1 channel at postsynaptic dense bodies microdomains and converts it to a leak channel no longer sensitive to stimulation by arachidonic acid, acidic pH or mechanical stress, nor inhibited by Gq-coupled receptors but still under the negative control of Gs-coupled receptors (By similarity). Associates with ORAI1 pore-forming subunit of CRAC channels in Ca(2+) signaling microdomains where it recruits NFATC2/NFAT1 and couples store-operated Ca(2+) influx to calmodulin and calcineurin signaling and activation of NFAT-dependent transcriptional responses (PubMed:33941685). {ECO:0000250|UniProtKB:D3YVF0, ECO:0000269|PubMed:1512224, ECO:0000269|PubMed:25589740, ECO:0000269|PubMed:33941685}.
uniprot
proteins
mass_dalton
47088
uniprot
proteins
mutagenesis
MUTAGEN 36; /note="C->S: Loss of palmitoylation by ZDHHC2; when associated with S-129."; /evidence="ECO:0000269|PubMed:25589740"; MUTAGEN 129; /note="C->S: Loss of palmitoylation by ZDHHC2; when associated with S-36."; /evidence="ECO:0000269|PubMed:25589740"; MUTAGEN 392; /note="L->P: Prevents or diminishes RII binding."; /evidence="ECO:0000269|PubMed:1512224"; MUTAGEN 396; /note="A->P: Prevents or diminishes RII binding."; /evidence="ECO:0000269|PubMed:1512224"; MUTAGEN 400; /note="V->P: Prevents or diminishes RII binding."; /evidence="ECO:0000269|PubMed:1512224"; MUTAGEN 405; /note="Q->P: Prevents or diminishes RII binding."; /evidence="ECO:0000269|PubMed:1512224"; MUTAGEN 408; /note="I->P: Prevents or diminishes RII binding."; /evidence="ECO:0000269|PubMed:1512224
uniprot
proteins
post_translational_modification
PTM: Palmitoylated (PubMed:21771783, PubMed:25589740). Palmitoylation at Cys-36 and Cys-129 play a key role in the targeting of AKAP5 to lipid rafts (PubMed:21771783). Palmitoylation by ZDHHC2 is required for AKAP5 function in LTP-stimulated recycling endosome exocytosis (PubMed:25589740). {ECO:0000269|PubMed:21771783, ECO:0000269|PubMed:25589740}.
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
1512224
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1733921
uniprot
proteins
pubmed
21771783
uniprot
proteins
pubmed
24349250
uniprot
proteins
pubmed
25589740
uniprot
proteins
pubmed
33941685
uniprot
proteins
sequence_length
427
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic recycling endosome membrane {ECO:0000269|PubMed:21771783, ECO:0000269|PubMed:25589740}; Lipid-anchor {ECO:0000269|PubMed:21771783}. Cell projection, dendrite {ECO:0000250|UniProtKB:D3YVF0}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:D3YVF0}; Lipid-anchor. Note=Associates with lipid rafts. {ECO:0000269|PubMed:21771783}.
uniprot
proteins