Grm6
entrez
24419
canonical
uniprot
P35349
canonical
ensembl
ENSRNOG00000000233
resolver
ensp
ENSRNOP00000000249
resolver
genesymbol
Grm6
resolver
genesymbol_syn
Gprc1f
resolver
genesymbol_syn
Mglur6
resolver
uniprot_entry
GRM6_RAT
resolver
amino_acid_sequence
MGRLPVLLLWLAWWLSQAGIACGAGSVRLAGGLTLGGLFPVHARGAAGRACGALKKEQGVHRLEAMLYALDRVNADPELLPGVRLGARLLDTCSRDTYALEQALSFVQALIRGRGDGDEASVRCPGGVPPLRSAPPERVVAVVGASASSVSIMVANVLRLFAIPQISYASTAPELSDSTRYDFFSRVVPPDSYQAQAMVDIVRALGWNYVSTLASEGNYGESGVEAFVQISREAGGVCIAQSIKIPREPKPGEFHKVIRRLMETPNARGIIIFANEDDIRRVLEATRQANLTGHFLWVGSDSWGSKISPILNLEEEAVGAITILPKRASIDGFDQYFMTRSLENNRRNIWFAEFWEENFNCKLTSSGGQSDDSTRKCTGEERIGQDSAYEQEGKVQFVIDAVYAIAHALHSMHQALCPGHTGLCPAMEPTDGRTLLHYIRAVRFNGSAGTPVMFNENGDAPGRYDIFQYQATNGSASSGGYQAVGQWAEALRLDMEVLRWSGDPHEVPPSQCSLPCGPGERKKMVKGVPCCWHCEACDGYRFQVDEFTCEACPGDMRPTPNHTGCRPTPVVRLTWSSPWAALPLLLAVLGIMATTTIMATFMRHNDTPIVRASGRELSYVLLTGIFLIYAITFLMVAEPCAAICAARRLLLGLGTTLSYSALLTKTNRIYRIFEQGKRSVTPPPFISPTSQLVITFGLTSLQVVGVIAWLGAQPPHSVIDYEEQRTVDPEQARGVLKCDMSDLSLIGCLGYSLLLMVTCTVYAIKARGVPETFNEAKPIGFTMYTTCIIWLAFVPIFFGTAQSAEKIYIQTTTLTVSLSLSASVSLGMLYVPKTYVILFHPEQNVQKRKRSLKKTSTMAAPPQNENAEDAK
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity (By similarity). Signaling stimulates TRPM1 channel activity and Ca(2+) uptake. Required for normal vision. {ECO:0000250, ECO:0000269|PubMed:8389366}.
uniprot
proteins
mass_dalton
95089
uniprot
proteins
protein_family
G protein-coupled receptor 3 family
uniprot
proteins
pubmed
8389366
uniprot
proteins
sequence_length
871
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=Subject to trafficking from the endoplasmic reticulum to the Golgi apparatus and then to the cell membrane. Detected at dendritic tips of bipolar cells (By similarity). {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 580..602; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 617..637; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 649..667; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 692..712; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 743..764; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 778..800; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 814..839; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins