SINHCAF
entrez
58516
canonical
uniprot
Q9NP50
canonical
ensembl
ENSG00000139146
resolver
ensembl
ENSG00000276371
resolver
ensp
ENSP00000337477
resolver
ensp
ENSP00000393279
resolver
ensp
ENSP00000617960
resolver
ensp
ENSP00000643264
resolver
ensp
ENSP00000741212
resolver
ensp
ENSP00000741220
resolver
genesymbol
SINHCAF
resolver
genesymbol_syn
C12orf14
resolver
genesymbol_syn
FAM60A
resolver
hgnc
HGNC:30702
resolver
uniprot
D3DUV8
resolver
uniprot
Q9BSZ8
resolver
uniprot_entry
SHCAF_HUMAN
resolver
uniprot_sec
D3DUV8
resolver
uniprot_sec
Q9BSZ8
resolver
amino_acid_sequence
MFGFHKPKMYRSIEGCCICRAKSSSSRFTDSKRYEKDFQSCFGLHETRSGDICNACVLLVKRWKKLPAGSKKNWNHVVDARAGPSLKTTLKPKKVKTLSGNRIKSNQISKLQKEFKRHNSDAHSTTSSASPAQSPCYSNQSDDGSDTEMASGSNRTPVFSFLDLTYWKRQKICCGIIYKGRFGEVLIDTHLFKPCCSNKKAAAEKPEEQGPEPLPISTQEW
uniprot
proteins
function
FUNCTION: Subunit of the Sin3 deacetylase complex (Sin3/HDAC), this subunit is important for the repression of genes encoding components of the TGF-beta signaling pathway (PubMed:22865885, PubMed:22984288). Core component of a SIN3A complex (composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1) present in embryonic stem (ES) cells. Promotes the stability of SIN3A and its presence on chromatin and is essential for maintaining the potential of ES cells to proliferate rapidly, while ensuring a short G1-phase of the cell cycle, thereby preventing premature lineage priming (By similarity). {ECO:0000250|UniProtKB:Q8C8M1, ECO:0000269|PubMed:22865885, ECO:0000269|PubMed:22984288}.
uniprot
proteins
mass_dalton
24852
uniprot
proteins
protein_family
SINHCAF family
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15334068
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
22865885
uniprot
proteins
pubmed
22984288
uniprot
proteins
sequence_length
221
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8C8M1}.
uniprot
proteins