O70338
uniprot
O70338
canonical
activity_regulation
ACTIVITY REGULATION: In the presence of magnesium, manganese is inhibitory. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MRWLLPLSRTVTLAVVRLRRGICGLGMFYAVRRGRRTGVFLSWSECKAQVDRFPAARFKKFATEDEAWAFVRSSSSPDGSKGQESAHEQKSQAKTSKRPREPLGEGEELPEPGPKHTRQDTEPAAVVSKDTFSYMGESVIVYTDGCCSSNGRKRARAGIGVYWGPGHPLNVGIRLPGRQTNQRAEIHAACKAIMQAKAQNISKLVLYTDSMFTINGITNWVQGWKKNGWRTSTGKDVINKEDFMELDELTQGMDIQWMHIPGHSGFVGNEEADRLAREGAKQSED
uniprot
proteins
ec_number
3.1.26.4
uniprot
proteins
function
FUNCTION: Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. Plays a role in RNA polymerase II (RNAp II) transcription termination by degrading R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site and behind the elongating RNAp II. {ECO:0000250|UniProtKB:O60930}.
uniprot
proteins
mass_dalton
31805
uniprot
proteins
protein_family
RNase H family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9799596
uniprot
proteins
sequence_length
285
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
uniprot
proteins