Cox5b
entrez
94194
canonical
uniprot
P12075
canonical
ensembl
ENSRNOG00000016660
resolver
ensp
ENSRNOP00000022487
resolver
genesymbol
Cox5b
resolver
uniprot_entry
COX5B_RAT
resolver
amino_acid_sequence
MASRLLRGVGALAAQALRAHGPRGVAATRSMASGGGVPTDEEQATGLEREIMIAAQRGLDPYNMLPPKAASGTKEDPNLVPSVSNKRIVGCICEEDNCTVIWFWLHQGESQRCPNCGTHYKLVPYQMVH
uniprot
proteins
function
FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P04037}.
uniprot
proteins
mass_dalton
13915
uniprot
proteins
pathway_participation
PATHWAY: Energy metabolism; oxidative phosphorylation. {ECO:0000250|UniProtKB:P04037}.
uniprot
proteins
protein_family
Cytochrome c oxidase subunit 5B family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2549512
uniprot
proteins
pubmed
7601105
uniprot
proteins
pubmed
8206867
uniprot
proteins
sequence_length
129
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00428}; Peripheral membrane protein {ECO:0000250|UniProtKB:P00428}; Matrix side {ECO:0000250|UniProtKB:P00428}.
uniprot
proteins