Pax6
entrez
18508
canonical
uniprot
P63015
canonical
ensembl
ENSMUSG00000027168
resolver
ensp
ENSMUSP00000087870
resolver
ensp
ENSMUSP00000087878
resolver
ensp
ENSMUSP00000106711
resolver
ensp
ENSMUSP00000106715
resolver
ensp
ENSMUSP00000106716
resolver
ensp
ENSMUSP00000240832
resolver
genesymbol
Pax6
resolver
genesymbol_syn
Pax-6
resolver
genesymbol_syn
Sey
resolver
uniprot
P32117
resolver
uniprot
P70601
resolver
uniprot
Q3UTV5
resolver
uniprot
Q62222
resolver
uniprot
Q64037
resolver
uniprot
Q8CEI5
resolver
uniprot
Q8VBX9
resolver
uniprot
Q8VDB5
resolver
uniprot
Q921Q8
resolver
uniprot_entry
PAX6_MOUSE
resolver
uniprot_entry
Q8VBX9_MOUSE
resolver
uniprot_sec
P32117
resolver
uniprot_sec
P70601
resolver
uniprot_sec
Q3UTV5
resolver
uniprot_sec
Q62222
resolver
uniprot_sec
Q64037
resolver
uniprot_sec
Q8CEI5
resolver
uniprot_sec
Q8VDB5
resolver
uniprot_sec
Q921Q8
resolver
amino_acid_sequence
MQNSHSGVNQLGGVFVNGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATPEVVSKIAQYKRECPSIFAWEIRDRLLSEGVCTNDNIPSVSSINRVLRNLASEKQQMGADGMYDKLRMLNGQTGSWGTRPGWYPGTSVPGQPTQDGCQQQEGGGENTNSISSNGEDSDEAQMRLQLKRKLQRNRTSFTQEQIEALEKEFERTHYPDVFARERLAAKIDLPEARIQVWFSNRRAKWRREEKLRNQRRQASNTPSHIPISSSFSTSVYQPIPQPTTPVSSFTSGSMLGRTDTALTNTYSALPPMPSFTMANNLPMQPPVPSQTSSYSCMLPTSPSVNGRSYDTYTPPHMQTHMNSQPMGTSGTTSTGLISPGVSVPVQVPGSEPDMSQYWPRLQ
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Pax6 are the cause of a condition known as small eye (Sey) which results in the complete lack of eyes and nasal primordia. {ECO:0000269|PubMed:1684639}.
uniprot
proteins
function
FUNCTION: Transcription factor with important functions in the development of the eye, nose, central nervous system and pancreas. Required for the differentiation of pancreatic islet alpha cells (PubMed:9163426). Competes with PAX4 in binding to a common element in the glucagon, insulin and somatostatin promoters. Regulates specification of the ventral neuron subtypes by establishing the correct progenitor domains (By similarity). Acts as a transcriptional repressor of NFATC1-mediated gene expression (PubMed:23990468). {ECO:0000250, ECO:0000269|PubMed:23990468, ECO:0000269|PubMed:9163426}.
uniprot
proteins
mass_dalton
46683
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by TRIM11, leading to ubiquitination and proteasomal degradation. {ECO:0000269|PubMed:18628401}.; PTM: [Isoform 3]: Sumoylated by SUMO1 at 'Lys-91'. {ECO:0000269|PubMed:21084637}.
uniprot
proteins
protein_family
Paired homeobox family
uniprot
proteins
pubmed
11779807
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1612585
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1684639
uniprot
proteins
pubmed
1685142
uniprot
proteins
pubmed
1687460
uniprot
proteins
pubmed
17901057
uniprot
proteins
pubmed
18628401
uniprot
proteins
pubmed
21084637
uniprot
proteins
pubmed
23990468
uniprot
proteins
pubmed
9163426
uniprot
proteins
sequence_length
422
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23990468}.; SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000250|UniProtKB:P63016}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus {ECO:0000269|PubMed:21084637}. Cytoplasm {ECO:0000269|PubMed:21084637}.; SUBCELLULAR LOCATION: [Isoform 5a]: Nucleus {ECO:0000250|UniProtKB:P63016}.
uniprot
proteins