Fkbp4
entrez
260321
canonical
uniprot
Q9QVC8
canonical
ensembl
ENSRNOG00000006444
resolver
ensembl
ENSRNOG00055011116
resolver
ensembl
ENSRNOG00060018406
resolver
ensembl
ENSRNOG00065033702
resolver
ensp
ENSRNOP00000008737
resolver
ensp
ENSRNOP00055015217
resolver
ensp
ENSRNOP00060025692
resolver
ensp
ENSRNOP00065047686
resolver
enst
ENSRNOT00000008737
resolver
enst
ENSRNOT00055018859
resolver
enst
ENSRNOT00060031627
resolver
enst
ENSRNOT00065057901
resolver
genesymbol
Fkbp4
resolver
genesymbol_syn
Fkbp52
resolver
uniprot
A6IM14
resolver
uniprot
Q8K3U8
resolver
uniprot_entry
FKBP4_RAT
resolver
uniprot_sec
A6IM14
resolver
uniprot_sec
Q8K3U8
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by FK506. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MTAEEMKVAENGAQSAPLPLEGVDISPKQDEGVLKVIKREGTGTETAMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAVATMKVGEVCHITCKPEYAYGSAGSPPKIPPNATLVFEVELFEFKGEDLTEDEDGGIIRRIRTRGEGYARPNDGAMVEVALEGYYNDRLFDQRELCFEVGEGESLDLPCGLEEAIQRMEKGEHSIVYLKPSYAFGSVGKERFQIPPHAELRYEVHLKSFEKAKASWEMNSEEKLEQSNIVKERGTVYFKEGKYKQALLQYKKIVSWLEYESSFSGEEMQKVHALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFDLARADFQKVLQLYPSNKAAKTQLAVCQQRTRRQLAREKKLYANMFERLAEEEHKAKTEVAAGDHPTDAEMKGEPNNVAGNQAQVKTEA
uniprot
proteins
ec_number
5.2.1.8
uniprot
proteins
function
FUNCTION: Immunophilin protein with PPIase and co-chaperone activities (By similarity). Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90) (By similarity). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. May have a protective role against oxidative stress in mitochondria (By similarity). Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. The PPIase activity controls neuronal growth cones via regulation of TRPC1 channel opening. {ECO:0000250, ECO:0000269|PubMed:17435176, ECO:0000269|PubMed:20133804}.
uniprot
proteins
mass_dalton
51450
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by CK2 results in loss of HSP90 binding activity.
uniprot
proteins
pubmed
1376003
uniprot
proteins
pubmed
17435176
uniprot
proteins
pubmed
20133804
uniprot
proteins
sequence_length
458
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:17435176, ECO:0000269|PubMed:20133804}. Mitochondrion {ECO:0000250|UniProtKB:Q02790}. Nucleus {ECO:0000250|UniProtKB:P30416}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17435176}. Cell projection, axon {ECO:0000269|PubMed:20133804}. Note=Shuttles from mitochondria to nucleus; co-localizes in mitochondria with the glucocorticoid receptor (By similarity). Colocalized with MAPT/TAU in the distal part of the primary cortical neurons (PubMed:20133804). {ECO:0000250|UniProtKB:Q02790, ECO:0000269|PubMed:20133804}.
uniprot
proteins