Alx1
entrez
25401
canonical
uniprot
Q63087
canonical
ensembl
ENSRNOG00000004390
resolver
ensp
ENSRNOP00000006007
resolver
genesymbol
Alx1
resolver
genesymbol_syn
Cart1
resolver
uniprot
B0BMW6
resolver
uniprot_entry
ALX1_RAT
resolver
uniprot_entry
B0BMW6_RAT
resolver
amino_acid_sequence
MEFLSEKFALKSPPSKNSDFYMGTGGALEHVMETLDNESFYGKATAGKCVQAFGPLPRAEHHVRLDRTSPCQDSSVNYGITKVEGQPLHTELNRAMDGCNNLRMSPVKGMPEKSELDELGDKCDSNVSSSKKRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTEARVQVWFQNRRAKWRKRERYGQIQQAKSHFAATYDISVLPRTDSYPQIQNNLWAGNTSGGSVVTSCMLPRDASSCMTPYSHSPRTDSSYTGFSNHQNQFGHVPLNNFFTDSLLTGTTNGHAFETKPEFERRSSSIAVLRMKAKEHTANISWAM
uniprot
proteins
function
FUNCTION: Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes (PubMed:12929931). Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures (By similarity). Early on in development, it plays a role in forebrain mesenchyme survival (By similarity). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (By similarity). {ECO:0000250|UniProtKB:Q15699, ECO:0000269|PubMed:12929931}.
uniprot
proteins
mass_dalton
36904
uniprot
proteins
mutagenesis
MUTAGEN 131; /note="K->R: Loss of EP300-mediated transcriptional coactivation."; /evidence="ECO:0000269|PubMed:12929931"; MUTAGEN 133..136; /note="RRHR->GGHG: Loss of transcriptional activity. Loss of DNA-binding. Altered localization to the nucleus."; /evidence="ECO:0000269|PubMed:12390248"; MUTAGEN 188..190; /note="RKR->GKG: Loss of transcriptional activity. No effect on DNA-binding. Loss of homodimerization. Altered localization to the nucleus."; /evidence="ECO:0000269|PubMed:12390248
uniprot
proteins
post_translational_modification
PTM: Acetylated at Lys-131 by EP300; increases interaction with EP300 and stimulates ALX1 transcriptional activity. {ECO:0000269|PubMed:12929931}.
uniprot
proteins
protein_family
Paired homeobox family
uniprot
proteins
pubmed
12390248
uniprot
proteins
pubmed
12559496
uniprot
proteins
pubmed
12929931
uniprot
proteins
pubmed
7690966
uniprot
proteins
sequence_length
326
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12390248, ECO:0000269|PubMed:12929931}.
uniprot
proteins