CAMK2D
entrez
817
canonical
uniprot
Q13557
canonical
ensembl
ENSG00000145349
resolver
ensp
ENSP00000296402
resolver
ensp
ENSP00000339740
resolver
ensp
ENSP00000369098
resolver
ensp
ENSP00000378030
resolver
ensp
ENSP00000378032
resolver
ensp
ENSP00000422566
resolver
ensp
ENSP00000423482
resolver
ensp
ENSP00000423677
resolver
ensp
ENSP00000424245
resolver
ensp
ENSP00000425824
resolver
ensp
ENSP00000514099
resolver
ensp
ENSP00000514100
resolver
ensp
ENSP00000514338
resolver
ensp
ENSP00000514339
resolver
ensp
ENSP00000514340
resolver
ensp
ENSP00000514341
resolver
ensp
ENSP00000514343
resolver
ensp
ENSP00000514344
resolver
ensp
ENSP00000514345
resolver
ensp
ENSP00000514347
resolver
ensp
ENSP00000514375
resolver
ensp
ENSP00000514376
resolver
ensp
ENSP00000516207
resolver
ensp
ENSP00000516209
resolver
ensp
ENSP00000537857
resolver
ensp
ENSP00000537858
resolver
ensp
ENSP00000537859
resolver
ensp
ENSP00000537861
resolver
ensp
ENSP00000617106
resolver
ensp
ENSP00000617107
resolver
ensp
ENSP00000617116
resolver
ensp
ENSP00000664927
resolver
ensp
ENSP00000664928
resolver
ensp
ENSP00000664929
resolver
ensp
ENSP00000664930
resolver
ensp
ENSP00000664931
resolver
ensp
ENSP00000720990
resolver
ensp
ENSP00000720991
resolver
enst
ENST00000505990
resolver
enst
ENST00000511664
resolver
enst
ENST00000514328
resolver
enst
ENST00000699373
resolver
enst
ENST00000699374
resolver
enst
ENST00000699375
resolver
enst
ENST00000699376
resolver
enst
ENST00000699378
resolver
enst
ENST00000699379
resolver
enst
ENST00000699380
resolver
enst
ENST00000699417
resolver
enst
ENST00000706055
resolver
enst
ENST00000706057
resolver
enst
ENST00000947047
resolver
enst
ENST00000947048
resolver
genesymbol
CAMK2D
resolver
genesymbol_syn
CAMKD
resolver
hgnc
HGNC:1462
resolver
uniprot
A0A8V8TN60
resolver
uniprot
A0A8V8TN65
resolver
uniprot
A0A8V8TN88
resolver
uniprot
A0A8V8TNA1
resolver
uniprot
A0A8V8TNA7
resolver
uniprot
A0A8V8TPJ8
resolver
uniprot
A0A8V8TPY4
resolver
uniprot
A0A994J516
resolver
uniprot
A0A994J5B0
resolver
uniprot
A8MVS8
resolver
uniprot
D6R938
resolver
uniprot
E9PBG7
resolver
uniprot
E9PF82
resolver
uniprot
Q52PK4
resolver
uniprot
Q59G21
resolver
uniprot
Q8N553
resolver
uniprot
Q9UGH6
resolver
uniprot
Q9UQE9
resolver
uniprot_entry
A0A8V8TN60_HUMAN
resolver
uniprot_entry
A0A8V8TN65_HUMAN
resolver
uniprot_entry
A0A8V8TN88_HUMAN
resolver
uniprot_entry
A0A8V8TNA1_HUMAN
resolver
uniprot_entry
A0A8V8TNA7_HUMAN
resolver
uniprot_entry
A0A8V8TPJ8_HUMAN
resolver
uniprot_entry
A0A8V8TPY4_HUMAN
resolver
uniprot_entry
A0A994J516_HUMAN
resolver
uniprot_entry
A0A994J5B0_HUMAN
resolver
uniprot_entry
D6R938_HUMAN
resolver
uniprot_entry
E9PBG7_HUMAN
resolver
uniprot_entry
E9PF82_HUMAN
resolver
uniprot_entry
KCC2D_HUMAN
resolver
uniprot_sec
A8MVS8
resolver
uniprot_sec
Q52PK4
resolver
uniprot_sec
Q59G21
resolver
uniprot_sec
Q8N553
resolver
uniprot_sec
Q9UGH6
resolver
uniprot_sec
Q9UQE9
resolver
activity_regulation
ACTIVITY REGULATION: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity. {ECO:0000269|PubMed:14722083}.
uniprot
proteins
amino_acid_sequence
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKESTESSNTTIEDEDVKARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALSKSNKPIHTIILNPHVHLVGDDAACIAYIRLTQYMDGSGMPKTMQSEETRVWHRRDGKWQNVHFHRSGSPTVPIKPPCIPNGKENFSGGTSLWQNI
uniprot
proteins
ec_number
2.7.11.17
uniprot
proteins
function
FUNCTION: Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17179159). Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis (PubMed:16690701). May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q6PHZ2, ECO:0000269|PubMed:16690701, ECO:0000269|PubMed:17179159}.
uniprot
proteins
mass_dalton
56369
uniprot
proteins
post_translational_modification
PTM: Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state. {ECO:0000269|PubMed:16690701}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
CaMK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10189359
uniprot
proteins
pubmed
10819240
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14722083
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16690701
uniprot
proteins
pubmed
17157285
uniprot
proteins
pubmed
17179159
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19482609
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20668654
uniprot
proteins
pubmed
20673813
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9060999
uniprot
proteins
sequence_length
499
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Sarcoplasmic reticulum membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
uniprot
proteins