Htra1
entrez
56213
canonical
uniprot
Q9R118
canonical
ensembl
ENSMUSG00000006205
resolver
ensp
ENSMUSP00000006367
resolver
enst
ENSMUST00000006367
resolver
genesymbol
Htra1
resolver
genesymbol_syn
Htra
resolver
genesymbol_syn
Prss11
resolver
uniprot
Q8BN04
resolver
uniprot
Q8BN05
resolver
uniprot
Q91WS3
resolver
uniprot
Q9QZK6
resolver
uniprot_entry
HTRA1_MOUSE
resolver
uniprot_sec
Q8BN04
resolver
uniprot_sec
Q8BN05
resolver
uniprot_sec
Q91WS3
resolver
uniprot_sec
Q9QZK6
resolver
amino_acid_sequence
MQSLRTTLLSLLLLLLAAPSLALPSGTGRSAPAATVCPEHCDPTRCAPPPTDCEGGRVRDACGCCEVCGALEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCGSDAKTYTNLCQLRAASRRSEKLRQPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELYRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKNRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAVTKKKYIGIRMMSLTSSKAKELKDRHRDFPDVLSGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVTANDVSDVIKKENTLNMVVRRGNEDIVITVIPEEIDP
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, but it is unclear whether it leads to the proteolytic degradation of TGF-beta proteins themselves (PubMed:18551132) or not (PubMed:14973287). By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets. {ECO:0000269|PubMed:14973287, ECO:0000269|PubMed:15993670, ECO:0000269|PubMed:18551132, ECO:0000269|PubMed:22049084}.
uniprot
proteins
mass_dalton
51214
uniprot
proteins
mutagenesis
MUTAGEN 171; /note="F->D: Loss of efficient trimer formation."; /evidence="ECO:0000269|PubMed:15101818"; MUTAGEN 328; /note="S->A: Loss of enzymatic activity. No effect on BMP4-binding."; /evidence="ECO:0000269|PubMed:14973287
uniprot
proteins
protein_family
Peptidase S1C family
uniprot
proteins
pubmed
14973287
uniprot
proteins
pubmed
15101818
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15993670
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18551132
uniprot
proteins
pubmed
22049084
uniprot
proteins
sequence_length
480
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q92743}. Secreted {ECO:0000250|UniProtKB:Q92743}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q92743}. Note=Predominantly secreted. Also found associated with the plasma membrane. {ECO:0000250|UniProtKB:Q92743}.
uniprot
proteins