Dbh
entrez
25699
canonical
uniprot
Q05754
canonical
ensembl
ENSRNOG00000006641
resolver
ensp
ENSRNOP00000057915
resolver
enst
ENSRNOT00000061201
resolver
genesymbol
Dbh
resolver
uniprot
G3V9S4
resolver
uniprot_entry
DOPO_RAT
resolver
uniprot_entry
G3V9S4_RAT
resolver
amino_acid_sequence
MQPHLSHQPCWSLPSPSVREAASMYGTAVAIFLVILVAALQGSEPPESPFPYHIPLDPEGTLELSWNVSYDQEIIHFQLQVQGPRAGVLFGMSDRGEMENADLVMLWTDGDRTYFADAWSDQKGQIHLDTHQDYQLLQAQRVSNSLSLLFKRPFVTCDPKDYVIEDDTVHLVYGILEEPFQSLEAINTSGLHTGLQQVQLLKPEVSTPAMPADVQTMDIRAPDVLIPSTETTYWCYITELPLHFPRHHIIMYEAIVTEGNEALVHHMEVFQCTNESEAFPMFNGPCDSKMKPDRLNYCRHVLAAWALGAKAFYYPEEAGVPLGSSGSSRFLRLEVHYHNPRNIQGRRDSSGIRLHYTASLRPNEAGIMELGLVYTPLMAIPPQETTFVLTGYCTDRCTQMALPKSGIRIFASQLHTHLTGRKVITVLARDGQQREVVNRDNHYSPHFQEIRMLKNAVTVHQGDVLITSCTYNTENRTMATVGGFGILEEMCVNYVHYYPKTELELCKSAVDDGFLQKYFHIVNRFGNEEVCTCPQASVPQQFASVPWNSFNRDMLKALYNYAPISVHCNKTSAVRFPGNWNLQPLPNITSAVEEPDPRCPIRQTRGPAGPFVVITHGGRH
uniprot
proteins
ec_number
1.14.17.1
uniprot
proteins
function
FUNCTION: Catalyzes the hydroxylation of dopamine to noradrenaline (also known as norepinephrine), and is thus vital for regulation of these neurotransmitters. {ECO:0000250|UniProtKB:P09172}.
uniprot
proteins
mass_dalton
69875
uniprot
proteins
pathway_participation
PATHWAY: Catecholamine biosynthesis; (R)-noradrenaline biosynthesis; (R)-noradrenaline from dopamine: step 1/1. {ECO:0000250|UniProtKB:P09172}.
uniprot
proteins
post_translational_modification
PTM: Proteolytic cleavage after the membrane-anchor leads to the release of the soluble form. {ECO:0000250|UniProtKB:P15101}.; PTM: N-glycosylated. {ECO:0000250|UniProtKB:P09172}.
uniprot
proteins
protein_family
Copper type II ascorbate-dependent monooxygenase family
uniprot
proteins
pubmed
11418593
uniprot
proteins
pubmed
2325165
uniprot
proteins
sequence_length
620
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Soluble dopamine beta-hydroxylase]: Cytoplasmic vesicle, secretory vesicle lumen {ECO:0000250|UniProtKB:P09172}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen {ECO:0000250|UniProtKB:P09172}. Secreted {ECO:0000250|UniProtKB:P09172}.; SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:P09172}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P09172}. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane {ECO:0000305|PubMed:11418593}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P09172}.
uniprot
proteins
transmembrane_region
TRANSMEM 20..40; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins