Bcl2l10
entrez
12049
canonical
uniprot
Q9Z0F3
canonical
ensembl
ENSMUSG00000032191
resolver
ensp
ENSMUSP00000034709
resolver
enst
ENSMUST00000034709
resolver
genesymbol
Bcl2l10
resolver
genesymbol_syn
Bcl-b
resolver
genesymbol_syn
Boo
resolver
genesymbol_syn
Diva
resolver
uniprot
Q3ULP5
resolver
uniprot
Q7TPY8
resolver
uniprot_entry
B2L10_MOUSE
resolver
uniprot_sec
Q3ULP5
resolver
uniprot_sec
Q7TPY8
resolver
amino_acid_sequence
MADSQDPLHERTRRLLSDYIFFCAREPDTPEPPPTSVEAALLRSVTRQIQQEHQEFFSSFCESRGNRLELVKQMADKLLSKDQDFSWSQLVMLLAFAGTLMNQGPYMAVKQKRDLGNRVIVTRDCCLIVNFLYNLLMGRRHRARLEALGGWDGFCRFFKNPLPLGFWRRLLIQAFLSGFFATAIFFIWKRL
uniprot
proteins
function
FUNCTION: Promotes cell survival by suppressing apoptosis induced by BAX but not BAK (By similarity). Increases binding of AHCYL1/IRBIT to ITPR1 (By similarity). Reduces ITPR1-mediated calcium release from the endoplasmic reticulum cooperatively with AHCYL1/IRBIT under normal cellular conditions (By similarity). Under apoptotic stress conditions, dissociates from ITPR1 and is displaced from mitochondria-associated endoplasmic reticulum membranes, leading to increased Ca(2+) transfer to mitochondria which promotes apoptosis (By similarity). Required for the correct formation of the microtubule organizing center during oocyte cell division, potentially via regulation of protein abundance and localization of other microtubule organizing center components such as AURKA and TPX2 (PubMed:27753540). {ECO:0000250|UniProtKB:Q9HD36, ECO:0000269|PubMed:27753540}.
uniprot
proteins
mass_dalton
22302
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated by UBQLN1; results in stabilization of BCL2L10 protein abundance and in relocalization from mitochondria to cytoplasm. {ECO:0000250|UniProtKB:Q9HD36}.
uniprot
proteins
protein_family
Bcl-2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17532299
uniprot
proteins
pubmed
20455273
uniprot
proteins
pubmed
27753540
uniprot
proteins
pubmed
9829980
uniprot
proteins
pubmed
9878060
uniprot
proteins
sequence_length
191
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9HD36}. Nucleus membrane {ECO:0000250|UniProtKB:Q9HD36}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9HD36}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:27753540}. Note=Localizes to mitochondria-associated endoplasmic reticulum membranes (MAMs) (By similarity). Localization to MAMs is greatly reduced under apoptotic stress conditions (By similarity). {ECO:0000250|UniProtKB:Q9HD36}.
uniprot
proteins
transmembrane_region
TRANSMEM 166..183; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins