SERPINE1
entrez
5054
canonical
uniprot
P05121
canonical
ensembl
ENSG00000106366
resolver
ensp
ENSP00000223095
resolver
ensp
ENSP00000620119
resolver
ensp
ENSP00000620121
resolver
genesymbol
SERPINE1
resolver
genesymbol_syn
PAI1
resolver
genesymbol_syn
PLANH1
resolver
hgnc
HGNC:8583
resolver
uniprot
B7Z4S0
resolver
uniprot
B7ZAB0
resolver
uniprot
F8WD53
resolver
uniprot_entry
B7ZAB0_HUMAN
resolver
uniprot_entry
PAI1_HUMAN
resolver
uniprot_sec
B7Z4S0
resolver
uniprot_sec
F8WD53
resolver
amino_acid_sequence
MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
uniprot
proteins
disease_involvement
DISEASE: Plasminogen activator inhibitor-1 deficiency (PAI-1D) [MIM:613329]: A hematologic disorder characterized by increased bleeding after trauma, injury, or surgery. Affected females have menorrhagia. The bleeding defect is due to increased fibrinolysis of fibrin blood clots due to deficiency of plasminogen activator inhibitor-1, which inhibits tissue and urinary activators of plasminogen. {ECO:0000269|PubMed:8481516, ECO:0000269|PubMed:9207454}. Note=The disease is caused by variants affecting the gene represented in this entry. A rare PAI-1D mutation resulting in a frameshift and protein truncation has been found in an Old Order Amish community. Homozygous mutation carriers suffer from episodes of major hemorrhage, while heterozygous carriers do not manifest abnormal bleeding (PubMed:9207454). Heterozygosity for the mutation is associated with longer leukocyte telomere length, lower fasting insulin levels, lower prevalence of diabetes mellitus, and a longer life span (PubMed:29152572). {ECO:0000269|PubMed:29152572, ECO:0000269|PubMed:9207454}.
uniprot
proteins
function
FUNCTION: Serine protease inhibitor. Inhibits TMPRSS7 (PubMed:15853774). Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed:17912461, PubMed:8481516, PubMed:9207454, PubMed:21925150). As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed:9175705). Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed:15001579, PubMed:9168821). It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed:18386027). It is involved in cellular and replicative senescence (PubMed:16862142). Plays a role in alveolar type 2 cells senescence in the lung (By similarity). Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed:25808697, PubMed:27046084). {ECO:0000250|UniProtKB:P22777, ECO:0000269|PubMed:15001579, ECO:0000269|PubMed:15853774, ECO:0000269|PubMed:16862142, ECO:0000269|PubMed:17912461, ECO:0000269|PubMed:18386027, ECO:0000269|PubMed:21925150, ECO:0000269|PubMed:25808697, ECO:0000269|PubMed:27046084, ECO:0000269|PubMed:8481516, ECO:0000269|PubMed:9168821, ECO:0000269|PubMed:9175705, ECO:0000269|PubMed:9207454}.
uniprot
proteins
mass_dalton
45060
uniprot
proteins
mutagenesis
MUTAGEN 197; /note="Q->C: Increased half-life of the active form when associated with C-355."; /evidence="ECO:0000269|PubMed:17912461"; MUTAGEN 355; /note="G->C: Increased half-life of the active form when associated with C-197."; /evidence="ECO:0000269|PubMed:17912461
uniprot
proteins
post_translational_modification
PTM: Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg-|-Met-370 bond.
uniprot
proteins
protein_family
Serpin family
uniprot
proteins
pubmed
10368279
uniprot
proteins
pubmed
10391209
uniprot
proteins
pubmed
10731421
uniprot
proteins
pubmed
11384978
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15001579
uniprot
proteins
pubmed
15053742
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15853774
uniprot
proteins
pubmed
16862142
uniprot
proteins
pubmed
1731226
uniprot
proteins
pubmed
17912461
uniprot
proteins
pubmed
18386027
uniprot
proteins
pubmed
21925150
uniprot
proteins
pubmed
22905912
uniprot
proteins
pubmed
24041930
uniprot
proteins
pubmed
2430793
uniprot
proteins
pubmed
25808697
uniprot
proteins
pubmed
2612914
uniprot
proteins
pubmed
27046084
uniprot
proteins
pubmed
2820474
uniprot
proteins
pubmed
28296156
uniprot
proteins
pubmed
29152572
uniprot
proteins
pubmed
3025016
uniprot
proteins
pubmed
3026837
uniprot
proteins
pubmed
3092219
uniprot
proteins
pubmed
3097076
uniprot
proteins
pubmed
3132455
uniprot
proteins
pubmed
3262512
uniprot
proteins
pubmed
7522053
uniprot
proteins
pubmed
7552714
uniprot
proteins
pubmed
8481516
uniprot
proteins
pubmed
9168821
uniprot
proteins
pubmed
9175705
uniprot
proteins
pubmed
9194591
uniprot
proteins
pubmed
9207454
uniprot
proteins
pubmed
9634700
uniprot
proteins
sequence_length
402
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2430793}.
uniprot
proteins