ATP6V1G1
entrez
9550
canonical
uniprot
O75348
canonical
ensembl
ENSG00000136888
resolver
ensp
ENSP00000363162
resolver
enst
ENST00000374050
resolver
genesymbol
ATP6V1G1
resolver
genesymbol_syn
ATP6G
resolver
genesymbol_syn
ATP6G1
resolver
genesymbol_syn
ATP6J
resolver
hgnc
HGNC:864
resolver
uniprot
Q6IB33
resolver
uniprot_entry
VATG1_HUMAN
resolver
uniprot_sec
Q6IB33
resolver
amino_acid_sequence
MASQSQGIQQLLQAEKRAAEKVSEARKRKNRRLKQAKEEAQAEIEQYRLQREKEFKAKEAAALGSRGSCSTEVEKETQEKMTILQTYFRQNRDEVLDNLLAFVCDIRPEIHENYRING
uniprot
proteins
function
FUNCTION: Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32001091, PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (PubMed:32001091). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (PubMed:22053050). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (PubMed:28296633). {ECO:0000269|PubMed:22053050, ECO:0000269|PubMed:28296633, ECO:0000269|PubMed:33065002, ECO:0000303|PubMed:32001091}.
uniprot
proteins
mass_dalton
13758
uniprot
proteins
protein_family
V-ATPase G subunit family
uniprot
proteins
pubmed
12384298
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22053050
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28296633
uniprot
proteins
pubmed
29993276
uniprot
proteins
pubmed
32001091
uniprot
proteins
pubmed
33065002
uniprot
proteins
pubmed
9653160
uniprot
proteins
sequence_length
118
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:29993276}.
uniprot
proteins