Itln1
entrez
16429
canonical
uniprot
O88310
canonical
ensembl
ENSMUSG00000038209
resolver
ensp
ENSMUSP00000043837
resolver
enst
ENSMUST00000043094
resolver
genesymbol
Itln1
resolver
genesymbol_syn
Intl
resolver
genesymbol_syn
Itln
resolver
genesymbol_syn
Itln1a
resolver
genesymbol_syn
Itlna
resolver
uniprot
D9J349
resolver
uniprot
Q5IWS3
resolver
uniprot_entry
D9J349_MOUSE
resolver
uniprot_entry
ITL1A_MOUSE
resolver
uniprot_sec
Q5IWS3
resolver
amino_acid_sequence
MTQLGFLLFIMVATRGCSAAEENLDTNRWGNSFFSSLPRSCKEIKQEHTKAQDGLYFLRTKNGVIYQTFCDMTTAGGGWTLVASVHENNMRGKCTVGDRWSSQQGNRADYPEGDGNWANYNTFGSAEAATSDDYKNPGYFDIQAENLGIWHVPNKSPLHNWRKSSLLRYRTFTGFLQHLGHNLFGLYKKYPVKYGEGKCWTDNGPALPVVYDFGDARKTASYYSPSGQREFTAGYVQFRVFNNERAASALCAGVRVTGCNTEHHCIGGGGFFPEGNPVQCGDFASFDWDGYGTHNGYSSSRKITEAAVLLFYR
uniprot
proteins
function
FUNCTION: Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed:26148048). Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris. Does not bind mammalian glycans. Probably plays a role in the defense system against microorganisms. May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Increases AKT phosphorylation in the absence and presence of insulin. May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (By similarity). {ECO:0000250|UniProtKB:Q8WWA0, ECO:0000269|PubMed:26148048}.
uniprot
proteins
mass_dalton
34953
uniprot
proteins
pubmed
14720597
uniprot
proteins
pubmed
15222482
uniprot
proteins
pubmed
15265922
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16866365
uniprot
proteins
pubmed
16936804
uniprot
proteins
pubmed
17420014
uniprot
proteins
pubmed
17621593
uniprot
proteins
pubmed
26148048
uniprot
proteins
pubmed
9790983
uniprot
proteins
sequence_length
313
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8WWA0}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q8WWA0}. Secreted {ECO:0000250|UniProtKB:Q8WWA0}. Note=Enriched in lipid rafts. {ECO:0000269|PubMed:16866365}.
uniprot
proteins