Erfe
entrez
227358
canonical
uniprot
Q6PGN1
canonical
ensembl
ENSMUSG00000047443
resolver
ensp
ENSMUSP00000084073
resolver
ensp
ENSMUSP00000316348
resolver
enst
ENSMUST00000086861
resolver
genesymbol
Erfe
resolver
genesymbol_syn
C1qtnf15
resolver
genesymbol_syn
Ctrp15
resolver
genesymbol_syn
Fam132b
resolver
uniprot
E3VWA0
resolver
uniprot
Q8CE11
resolver
uniprot_entry
ERFE_MOUSE
resolver
uniprot_sec
E3VWA0
resolver
uniprot_sec
Q8CE11
resolver
amino_acid_sequence
MASTRRPVGARTLLACASLLAAMGLGVPESAEPVGTHARPQPPGAELPAPPANSPPEPTIAHAHSVDPRDAWMLFVKQSDKGINSKRRSKARRLKLGLPGPPGPPGPQGPPGPFIPSEVLLKEFQLLLKGAVRQRESHLEHCTRDLTTPASGSPSRVPAAQELDSQDPGALLALLAATLAQGPRAPRVEAAFHCRLRRDVQVDRRALHELGIYYLPEVEGAFHRGPGLNLTSGQYTAPVAGFYALAATLHVALTEQPRKGPTRPRDRLRLLICIQSLCQHNASLETVMGLENSSELFTISVNGVLYLQAGHYTSVFLDNASGSSLTVRSGSHFSAILLGL
uniprot
proteins
function
FUNCTION: Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores (PubMed:24880340, PubMed:30097509, PubMed:31800957, PubMed:34002695). Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake (PubMed:22351773). Inhibits apoptosis and inflammatory response in cardiomyocytes via promotion of sphingosine-1-phosphate (S1P) and cAMP-dependent activation of AKT signaling (PubMed:30566056). Inhibits autophagy induced by nutrient deficiency in hepatocytes via promoting the phosphorylation of IRS1, AKT, and MTOR, and thereby subsequent activation of the AKT-MTOR signaling pathway (PubMed:24187137). Negatively regulates the differentiation of osteoblasts, potentially via sequestering BMP2, and thereby inhibits the activation of SMAD signaling (PubMed:34002695). The reduction in BMP2 signaling in osteoblasts also results in an increase in expression of the osteoclastogenesis-promoting factors TNFSF11/RANKL and SOST, thereby indirectly promotes bone resorption (PubMed:34002695). {ECO:0000269|PubMed:22351773, ECO:0000269|PubMed:24187137, ECO:0000269|PubMed:24880340, ECO:0000269|PubMed:30097509, ECO:0000269|PubMed:30566056, ECO:0000269|PubMed:31800957, ECO:0000269|PubMed:34002695}.
uniprot
proteins
mass_dalton
36265
uniprot
proteins
mutagenesis
MUTAGEN 142; /note="C->A: Enhances secretion and favors trimer formation."; /evidence="ECO:0000269|PubMed:32602701"; MUTAGEN 194; /note="C->A: Enhances secretion and reduces the formation of higher molecular weight oligomers."; /evidence="ECO:0000269|PubMed:32602701"; MUTAGEN 229; /note="N->Q: Abolishes glycosylation. Abolishes secretion; when associated with Q-281."; /evidence="ECO:0000269|PubMed:32602701"; MUTAGEN 273; /note="C->A: Abolishes secretion."; /evidence="ECO:0000269|PubMed:32602701"; MUTAGEN 278; /note="C->A: Abolishes secretion."; /evidence="ECO:0000269|PubMed:32602701"; MUTAGEN 281; /note="N->Q: Abolishes glycosylation. Abolishes secretion; when associated with Q-229."; /evidence="ECO:0000269|PubMed:32602701"; MUTAGEN 292; /note="N->Q: No effect on secretion."; /evidence="ECO:0000269|PubMed:32602701"; MUTAGEN 319; /note="N->Q: Abolishes secretion as a result of protein misfolding, protein is retained in the endoplasmic reticulum."; /evidence="ECO:0000269|PubMed:32602701"; MUTAGEN 321; /note="S->Q: No effect on secretion or protein folding."; /evidence="ECO:0000269|PubMed:32602701
uniprot
proteins
post_translational_modification
PTM: N-glycosylated; required for secretion of the mature protein. {ECO:0000269|PubMed:22351773, ECO:0000269|PubMed:32602701}.
uniprot
proteins
protein_family
Adipolin/erythroferrone family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
22351773
uniprot
proteins
pubmed
24187137
uniprot
proteins
pubmed
24880340
uniprot
proteins
pubmed
30097509
uniprot
proteins
pubmed
30566056
uniprot
proteins
pubmed
31800957
uniprot
proteins
pubmed
32602701
uniprot
proteins
pubmed
34002695
uniprot
proteins
sequence_length
340
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22351773, ECO:0000269|PubMed:24880340, ECO:0000269|PubMed:32602701, ECO:0000269|PubMed:34002695}. Note=Secreted when glycosylated at Asn-229 and Asn-281 (PubMed:32602701). Hydroxylation promotes secretion (PubMed:32602701). {ECO:0000269|PubMed:32602701}.
uniprot
proteins