Cyp8b1
entrez
13124
canonical
uniprot
O88962
canonical
ensembl
ENSMUSG00000050445
resolver
ensp
ENSMUSP00000052989
resolver
enst
ENSMUST00000062474
resolver
genesymbol
Cyp8b1
resolver
genesymbol_syn
Cyp12
resolver
uniprot
A0A0R4J0N7
resolver
uniprot
Q9R217
resolver
uniprot_entry
A0A0R4J0N7_MOUSE
resolver
uniprot_entry
CP8B1_MOUSE
resolver
uniprot_sec
Q9R217
resolver
amino_acid_sequence
MTLWCTVLGALLTVVGCLCLSLLLRHRRPWEPPLDKGFVPWLGHSMAFRKNMFEFLKGMRAKHGDVFTVQLGGQYFTFVMDPLSFGPIIKNTEKALDFQSYAKELVLKVFGYQSVDGDHRMIHLASTKHLMGQGLEELNQAMLDSLSLVMLGPKGSSLGASSWCEDGLFHFCYRILFKAGFLSLFGYTKDKQQDLDEADELFRKFRRFDFLFPRFVYSLLGPREWVEVSQLQRLFHQRLSVEQNLEKDGISCWLGYMLQFLREQGIASSMQDKFNFMMLWASQGNTGPTCFWVLLFLLKHQDAMKAVREEATRVMGKARLEAKKSFTFTPSALKHTPVLDSVMEESLRLCATPTLLRVVQEDYVLKMASGQEYQIRRGDKVALFPYLSVHMDPDIHPEPTAFKYDRFLNPDGTRKVDFYKSGKKIHHYSMPWGSGVSKCPGRFFALSEMKTFVLLMIMYFDFKLVDPDIPVPPIDPRRWGFGTSQPSHEVRFLYRLKPVQ
uniprot
proteins
ec_number
1.14.14.139
uniprot
proteins
function
FUNCTION: Sterol 12-alpha-hydroxylase involved in primary bile acid biosynthesis by catalyzing the 12alpha-hydroxylation of key intermediates including 7alpha-hydroxycholest-4-en-3-one, 3alpha,7alpha-dihydroxy-5beta-cholestan-26-oate and chenodeoxycholate along the classic pathway (By similarity). May also hydroxylate 5beta-cholestane-3alpha,7alpha-diol. Functions as a monooxygenase, inserting one atom of molecular oxygen into substrates while reducing the second to water, using electrons supplied by NADPH via cytochrome P450 reductase (CPR) (By similarity). Controls biliary balance of cholic acid and chenodeoxycholic acid, thereby regulating intestinal absorption of dietary lipids (PubMed:12393855, PubMed:28377401). {ECO:0000250|UniProtKB:O02766, ECO:0000250|UniProtKB:Q9UNU6, ECO:0000269|PubMed:12393855, ECO:0000269|PubMed:28377401}.
uniprot
proteins
mass_dalton
57706
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; bile acid biosynthesis. {ECO:0000269|PubMed:12393855, ECO:0000269|PubMed:28377401}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
10051404
uniprot
proteins
pubmed
12393855
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28377401
uniprot
proteins
sequence_length
500
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O02766}; Single-pass membrane protein {ECO:0000255}. Microsome membrane {ECO:0000250|UniProtKB:O02766}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins