Plxna3
entrez
309280
canonical
uniprot
D3ZPX4
canonical
ensembl
ENSRNOG00000060464
resolver
ensembl
ENSRNOG00055023625
resolver
ensembl
ENSRNOG00060006899
resolver
ensembl
ENSRNOG00065015179
resolver
ensp
ENSRNOP00000068735
resolver
ensp
ENSRNOP00055032980
resolver
ensp
ENSRNOP00060008440
resolver
ensp
ENSRNOP00065019674
resolver
enst
ENSRNOT00000083148
resolver
enst
ENSRNOT00055040594
resolver
enst
ENSRNOT00060011306
resolver
enst
ENSRNOT00065025134
resolver
genesymbol
Plxna3
resolver
uniprot_entry
PLXA3_RAT
resolver
amino_acid_sequence
MHTVCLLPLLFFTIGGCLGSSRPFRTFVVTDTTLTHLAVHRVTGEVFVGAVNRVFKLASNLTELRAHVTGPIEDNARCYPPPSMRVCSHRLVPVDNVNKLLLIDYAARRLVACGSIWQGICQFLRLDDLFKLGEPHHRKEHYLSGAQEPDSMAGVIVEQGQGPSKLFVGTAVDGKSEYFPTLSSRKLIDDEDSGDMFSLVYQDEFVSSQIKIPSDTLSLYPAFDIYYIYGFVSASFVYFLTLQLDTQQTLLDTAGEKFFTSKIVRMCAGDSEFYSYVEFPIGCSWRGVEYRLVQSAHLAKPGLLLAQALGVPADEDVLFTIFSQGQKNRANPPRQTILCLFTLSSINAHIRRRIQSCYRGEGTLALPWLLNKELPCINTPMQINGNFCGLVLNQPLGGLHVIEGLPLLADSTDGMASVAAYTYHQHSVVFIGTRSGNLKKVRVDGSQDAQLYETVSVVQGTPILRDLLFSPDHRHIYLLSEKQVSQLPVETCEQYLSCAACLGSGDPHCGWCVLQHRCCREGACPGASAPHGFAEELNKCIQVRVRPNNVSVTSSGVQLTVAMRNVPDLSLGVSCSFEEVTESEAILLPSGELRCPSPSLQELQTLTRGHGATHTVRLQLLSMETGVRFAGVDFVFYNCSALQSCMSCVGSPYPCHWCKYRHVCTSHPHECSFQEGRVHSPEGCPEILPRGDLLIPVGVMQPLTLRAKNLPQPQSGQKNYECVVRVQGRQHRVPAVRFNSSSVQCQNASYFYEGDEFGDTELDFSVVWDGDFPIDKPPSFRALLYKCWAQRPSCGLCLKADPRFNCGWCISEHRCQLRVHCPAPKSNWMHPSQKGARCSHPRITQIHPLTGPKEGGTRVTIVGENLGLTSREVGLRVAGVRCNSIPTEYVSAERIVCEMEESLVPSPPPGPAELCVGDCSADFRTQSQQLYSFVTPTLDRVSPTRGPASGGTRLTISGTSLDAGSRVTVIIRDGECQFVRRDAEAIVCISPISTLGPSQAPIILAIDHANISSTGVIYTYTQDPTVTHLEPTWSIINGSTSITVSGTHLLTVQEPRVRAKYRGIETTNTCQVINDTAMLCKAPGIFLGHPQPRAQGEHPDEFGFLLDHVQAARSLNRSSFTYYPDPSFEPLGPSGVLDVKPGSHVVLKGKNLIPAAAGSSRLNYTVLIGGQPCALTVSDTQLLCDSPSQTGRQPVMVLVGGLEFWLGTLHITADRALTLPAMVGLAAGGGLLLLAITVVLVAYKRKTQDADRTLKRLQLQMDNLESRVALECKEAFAELQTDINELTNHMDGVQIPFLDYRTYAVRVLFPGIEAHPVLKELDTPPNVEKALRLFGQLLHSRAFLLTFIHTLEAQSSFSMRDRGTVASLTMVALQSRLDYATGLLKQLLADLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLHCVCPESEGSAQVPVKVLNCDSITQAKDKLLDTVYKGIPYSQRPKAEDMDLEWRQGRMARIILQDEDITTKIECDWKRINSLAHYQVTDGSLVALVPKQVSAYNMANSFTFTRSLSRYESLLRAASSPDSLRSRAPMLTPDQEAGTKLWHLVKNHDHADHREGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHRGSALPLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHANDFNVLSALSELYFYVTKYRQEILTSLDRDASCRKHKLRQKLEQIITLVSSSS
uniprot
proteins
function
FUNCTION: Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
207982
uniprot
proteins
protein_family
Plexin family
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
1872
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 1221..1241; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins