SFN
entrez
2810
canonical
uniprot
P31947
canonical
ensembl
ENSG00000175793
resolver
ensp
ENSP00000340989
resolver
genesymbol
SFN
resolver
genesymbol_syn
HME1
resolver
hgnc
HGNC:10773
resolver
uniprot
Q6FH30
resolver
uniprot
Q6FH51
resolver
uniprot
Q96DH0
resolver
uniprot_entry
1433S_HUMAN
resolver
uniprot_sec
Q6FH30
resolver
uniprot_sec
Q6FH51
resolver
uniprot_sec
Q96DH0
resolver
amino_acid_sequence
MERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLLSVAYKNVVGGQRAAWRVLSSIEQKSNEEGSEEKGPEVREYREKVETELQGVCDTVLGLLDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKKEMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTLIMQLLRDNLTLWTADNAGEEGGEAPQEPQS
uniprot
proteins
function
FUNCTION: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Binding generally results in the modulation of the activity of the binding partner (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). Promotes cytosolic retention of GBP1 GTPase by binding to phosphorylated GBP1, thereby inhibiting the innate immune response (PubMed:37797010). Also acts as a TP53/p53-regulated inhibitor of G2/M progression (PubMed:9659898). When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). Acts to maintain desmosome cell junction adhesion in epithelial cells via interacting with and sequestering PKP3 to the cytoplasm, thereby restricting its translocation to existing desmosome structures and therefore maintaining desmosome protein homeostasis (PubMed:24124604). Also acts to facilitate PKP3 exchange at desmosome plaques, thereby maintaining keratinocyte intercellular adhesion (PubMed:29678907). May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (PubMed:18382127). Upstream regulator of YAP1 localization in keratinocytes: binds and sequester YAP1 in the cytoplasm, limiting YAP1-dependent transcription and driving Hippo signaling and cell differentiation (By similarity). {ECO:0000250|UniProtKB:O70456, ECO:0000269|PubMed:15731107, ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:22634725, ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:28202711, ECO:0000269|PubMed:29678907, ECO:0000269|PubMed:37797010, ECO:0000269|PubMed:9659898}.
uniprot
proteins
mass_dalton
27774
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation. {ECO:0000269|PubMed:18382127}.
uniprot
proteins
protein_family
14-3-3 family
uniprot
proteins
pubmed
1286667
uniprot
proteins
pubmed
1390337
uniprot
proteins
pubmed
15282546
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15731107
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
18382127
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19172738
uniprot
proteins
pubmed
19592491
uniprot
proteins
pubmed
19640509
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21625211
uniprot
proteins
pubmed
22634725
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23572552
uniprot
proteins
pubmed
24124604
uniprot
proteins
pubmed
26047703
uniprot
proteins
pubmed
28202711
uniprot
proteins
pubmed
29678907
uniprot
proteins
pubmed
33159816
uniprot
proteins
pubmed
36512409
uniprot
proteins
pubmed
37797010
uniprot
proteins
pubmed
41511042
uniprot
proteins
pubmed
8515476
uniprot
proteins
pubmed
9659898
uniprot
proteins
sequence_length
248
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24124604, ECO:0000269|PubMed:37797010, ECO:0000269|PubMed:41511042}. Nucleus {ECO:0000269|PubMed:41511042}. Secreted {ECO:0000305|PubMed:8515476}. Note=May be secreted by a non-classical secretory pathway. {ECO:0000305|PubMed:8515476}.
uniprot
proteins