Pdha2
entrez
117098
canonical
uniprot
Q06437
canonical
ensembl
ENSRNOG00000077743
resolver
ensembl
ENSRNOG00055011529
resolver
ensembl
ENSRNOG00060026187
resolver
ensembl
ENSRNOG00065026402
resolver
ensp
ENSRNOP00000099534
resolver
ensp
ENSRNOP00000099911
resolver
ensp
ENSRNOP00000101469
resolver
ensp
ENSRNOP00000105458
resolver
ensp
ENSRNOP00000108975
resolver
ensp
ENSRNOP00000111897
resolver
ensp
ENSRNOP00055015815
resolver
ensp
ENSRNOP00060037638
resolver
ensp
ENSRNOP00065037352
resolver
enst
ENSRNOT00000123491
resolver
enst
ENSRNOT00000128650
resolver
enst
ENSRNOT00000147417
resolver
enst
ENSRNOT00000155332
resolver
enst
ENSRNOT00000164505
resolver
enst
ENSRNOT00000166183
resolver
enst
ENSRNOT00055019595
resolver
enst
ENSRNOT00060045333
resolver
enst
ENSRNOT00065045553
resolver
genesymbol
Pdha2
resolver
uniprot_entry
ODPAT_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Pyruvate dehydrogenase activity is inhibited by phosphorylation of PDHA2; it is reactivated by dephosphorylation. {ECO:0000250|UniProtKB:P08559}.
uniprot
proteins
amino_acid_sequence
MRKMLATVLSQVFSGMVQKPALRGLLSSLKFSNDATCDIKKCDLYLLEQGPPTSTVLTREEALKYYRNMQVIRRMELKADQLYKQKFIRGFCHLCDGQEACNVGLEAGINPTDHIITSYRAHGLCYTRGLSVKSILAELTGRKGGCAKGKGGSMHMYAKNFYGGNGIVGAQVPLGAGVALACKYLKNGQICLALYGDGAANQGQVFEAYNMSALWKLPCVFICENNRYGMGTAIERSAASTDYHKKGFVIPGLRVNGMDILSVREATKFAADHCRSGKGPIVMELQTYRYHGHSMSDPGISYRTREEVQNVRSKSDPIMLLRERMISNNLSSVEELKEIDADVKKEVEEAAQFATTDPEPPLEDLANYLYHQNPPFEVRGAHKWLKFKSVS
uniprot
proteins
ec_number
1.2.4.1
uniprot
proteins
function
FUNCTION: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. {ECO:0000269|PubMed:9787790}.; FUNCTION: Together with PDHB forms the heterotetrameric E1 subunit of the pyruvate dehydrogenase (PDH) complex in testis. The PDH complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links cytoplasmic glycolysis and the mitochondrial tricarboxylic acid (TCA) cycle. It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and dihydrolipoamide dehydrogenase (E3) (By similarity). The E1 subunit catalyzes both the thiamine pyrophosphate (TPP)-dependent decarboxylation of pyruvate and the reductive acetylation of a lipoyl group covalently linked to the lipoyl-bearing domains of E2 (PubMed:9787790). {ECO:0000250|UniProtKB:P29803, ECO:0000269|PubMed:9787790}.
uniprot
proteins
mass_dalton
43393
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7916643
uniprot
proteins
pubmed
9787790
uniprot
proteins
sequence_length
391
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:P26284}.
uniprot
proteins