TRPV3
entrez
162514
canonical
uniprot
Q8NET8
canonical
ensembl
ENSG00000167723
resolver
ensp
ENSP00000301365
resolver
ensp
ENSP00000461518
resolver
genesymbol
TRPV3
resolver
hgnc
HGNC:18084
resolver
uniprot
B2KYM6
resolver
uniprot
Q8NDW7
resolver
uniprot
Q8NET9
resolver
uniprot
Q8NFH2
resolver
uniprot_entry
B2KYM6_HUMAN
resolver
uniprot_entry
TRPV3_HUMAN
resolver
uniprot_sec
Q8NDW7
resolver
uniprot_sec
Q8NET9
resolver
uniprot_sec
Q8NFH2
resolver
activity_regulation
ACTIVITY REGULATION: Activated by cannabinoid that binds to the vanilloid binding pocket (PubMed:38691614). Diphenylboronic anhydride induces pore dilation and enhances cation permeability by promoting the conversion to a homopentamer (PubMed:37648856). {ECO:0000269|PubMed:37648856, ECO:0000269|PubMed:38691614}.
uniprot
proteins
amino_acid_sequence
MKAHPKEMVPLMGKRVAAPSGNPAILPEKRPAEITPTKKSAHFFLEIEGFEPNPTVAKTSPPVFSKPMDSNIRQCISGNCDDMDSPQSPQDDVTETPSNPNSPSAQLAKEEQRRKKRRLKKRIFAAVSEGCVEELVELLVELQELCRRRHDEDVPDFLMHKLTASDTGKTCLMKALLNINPNTKEIVRILLAFAEENDILGRFINAEYTEEAYEGQTALNIAIERRQGDIAALLIAAGADVNAHAKGAFFNPKYQHEGFYFGETPLALAACTNQPEIVQLLMEHEQTDITSRDSRGNNILHALVTVAEDFKTQNDFVKRMYDMILLRSGNWELETTRNNDGLTPLQLAAKMGKAEILKYILSREIKEKRLRSLSRKFTDWAYGPVSSSLYDLTNVDTTTDNSVLEITVYNTNIDNRHEMLTLEPLHTLLHMKWKKFAKHMFFLSFCFYFFYNITLTLVSYYRPREEEAIPHPLALTHKMGWLQLLGRMFVLIWAMCISVKEGIAIFLLRPSDLQSILSDAWFHFVFFIQAVLVILSVFLYLFAYKEYLACLVLAMALGWANMLYYTRGFQSMGMYSVMIQKVILHDVLKFLFVYIVFLLGFGVALASLIEKCPKDNKDCSSYGSFSDAVLELFKLTIGLGDLNIQQNSKYPILFLFLLITYVILTFVLLLNMLIALMGETVENVSKESERIWRLQRARTILEFEKMLPEWLRSRFRMGELCKVAEDDFRLCLRINEVKWTEWKTHVSFLNEDPGPVRRTDFNKIQDSSRNNSKTTLNAFEEVEEFPETSV
uniprot
proteins
disease_involvement
DISEASE: Olmsted syndrome 1 (OLMS1) [MIM:614594]: An autosomal dominant, rare congenital disorder characterized by bilateral mutilating palmoplantar keratoderma and periorificial keratotic plaques with severe itching at all lesions. Diffuse alopecia, constriction of digits, and onychodystrophy have also been reported. Infections and squamous cell carcinomas can arise on the keratotic areas. The digital constriction may progress to autoamputation of fingers and toes. {ECO:0000269|PubMed:22405088, ECO:0000269|PubMed:22835024}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Palmoplantar keratoderma, non-epidermolytic, focal 2 (FNEPPK2) [MIM:616400]: A dermatological disorder characterized by non-epidermolytic, abnormal thickening of the skin on the palms and soles. Focal palmoplantar keratoderma consists of localized areas of hyperkeratosis located mainly on pressure points and sites of recurrent friction. {ECO:0000269|PubMed:25285920}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Non-selective calcium permeant cation channel (PubMed:12077604, PubMed:12077606, PubMed:26818531, PubMed:37648856, PubMed:38691614). It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius (PubMed:12077604, PubMed:12077606). Activation exhibits an outward rectification (PubMed:12077604). The channel pore can dilate to provide permeability to larger cations (PubMed:37648856). May associate with TRPV1 and may modulate its activity (PubMed:12077606). Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (PubMed:21593771). {ECO:0000269|PubMed:12077604, ECO:0000269|PubMed:12077606, ECO:0000269|PubMed:21593771, ECO:0000269|PubMed:26818531, ECO:0000269|PubMed:37648856, ECO:0000269|PubMed:38691614}.
uniprot
proteins
mass_dalton
90636
uniprot
proteins
mutagenesis
MUTAGEN 557; /note="L->A: Impairs channel activation by tetrahydrocannabivarin."; /evidence="ECO:0000269|PubMed:38691614"; MUTAGEN 560; /note="A->L,M: Impairs channel activation by tetrahydrocannabivarin."; /evidence="ECO:0000269|PubMed:38691614"; MUTAGEN 561; /note="N->A: Impairs channel activation by tetrahydrocannabivarin."; /evidence="ECO:0000269|PubMed:38691614"; MUTAGEN 563; /note="L->A: Impairs channel activation by tetrahydrocannabivarin."; /evidence="ECO:0000269|PubMed:38691614
uniprot
proteins
protein_family
TRPV3 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
protein_family
TrpV subfamily
uniprot
proteins
pubmed
12077604
uniprot
proteins
pubmed
12077606
uniprot
proteins
pubmed
21593771
uniprot
proteins
pubmed
22405088
uniprot
proteins
pubmed
22835024
uniprot
proteins
pubmed
25285920
uniprot
proteins
pubmed
26818531
uniprot
proteins
pubmed
37648856
uniprot
proteins
pubmed
38691614
uniprot
proteins
sequence_length
790
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26818531, ECO:0000269|PubMed:37648856, ECO:0000269|PubMed:38691614}; Multi-pass membrane protein {ECO:0000269|PubMed:37648856, ECO:0000269|PubMed:38691614}. Cytoplasm {ECO:0000269|PubMed:26818531}. Lysosome {ECO:0000269|PubMed:26818531}. Note=Targeted to lysosome for degradation in a SNX11-dependent manner. {ECO:0000269|PubMed:26818531}.
uniprot
proteins
transmembrane_region
TRANSMEM 431..460; /note="Helical; Name=S1"; /evidence="ECO:0000269|PubMed:37648856, ECO:0000269|PubMed:38691614, ECO:0007744|PDB:8GKA, ECO:0007744|PDB:8V6K, ECO:0007744|PDB:8V6L, ECO:0007744|PDB:8V6M, ECO:0007744|PDB:8V6N, ECO:0007744|PDB:8V6O"; TRANSMEM 480..508; /note="Helical; Name=S2"; /evidence="ECO:0000269|PubMed:37648856, ECO:0000269|PubMed:38691614, ECO:0007744|PDB:8GKA, ECO:0007744|PDB:8V6K, ECO:0007744|PDB:8V6L, ECO:0007744|PDB:8V6M, ECO:0007744|PDB:8V6N, ECO:0007744|PDB:8V6O"; TRANSMEM 520..540; /note="Helical; Name=S3"; /evidence="ECO:0000269|PubMed:37648856, ECO:0000269|PubMed:38691614, ECO:0007744|PDB:8GKA, ECO:0007744|PDB:8V6K, ECO:0007744|PDB:8V6L, ECO:0007744|PDB:8V6M, ECO:0007744|PDB:8V6N, ECO:0007744|PDB:8V6O"; TRANSMEM 546..566; /note="Helical; Name=S4"; /evidence="ECO:0000269|PubMed:37648856, ECO:0000269|PubMed:38691614, ECO:0007744|PDB:8GKA, ECO:0007744|PDB:8V6K, ECO:0007744|PDB:8V6L, ECO:0007744|PDB:8V6M, ECO:0007744|PDB:8V6N, ECO:0007744|PDB:8V6O"; TRANSMEM 570..608; /note="Helical; Name=S5"; /evidence="ECO:0000269|PubMed:37648856, ECO:0000269|PubMed:38691614, ECO:0007744|PDB:8GKA, ECO:0007744|PDB:8V6K, ECO:0007744|PDB:8V6L, ECO:0007744|PDB:8V6M, ECO:0007744|PDB:8V6N, ECO:0007744|PDB:8V6O"; TRANSMEM 650..686; /note="Helical; Name=S6"; /evidence="ECO:0000269|PubMed:37648856, ECO:0000269|PubMed:38691614, ECO:0007744|PDB:8GKA, ECO:0007744|PDB:8V6K, ECO:0007744|PDB:8V6L, ECO:0007744|PDB:8V6M, ECO:0007744|PDB:8V6N, ECO:0007744|PDB:8V6O
uniprot
proteins