PREB
entrez
10113
canonical
uniprot
Q9HCU5
canonical
ensembl
ENSG00000138073
resolver
ensp
ENSP00000260643
resolver
ensp
ENSP00000384032
resolver
ensp
ENSP00000591703
resolver
ensp
ENSP00000664271
resolver
enst
ENST00000260643
resolver
enst
ENST00000406567
resolver
genesymbol
PREB
resolver
genesymbol_syn
SEC12
resolver
hgnc
HGNC:9356
resolver
uniprot
B5MC98
resolver
uniprot
Q05DB2
resolver
uniprot
Q53SZ8
resolver
uniprot
Q9UH94
resolver
uniprot_entry
B5MC98_HUMAN
resolver
uniprot_entry
Q05DB2_HUMAN
resolver
uniprot_entry
SEC12_HUMAN
resolver
uniprot_sec
Q53SZ8
resolver
uniprot_sec
Q9UH94
resolver
amino_acid_sequence
MGRRRAPELYRAPFPLYALQVDPSTGLLIAAGGGGAAKTGIKNGVHFLQLELINGRLSASLLHSHDTETRATMNLALAGDILAAGQDAHCQLLRFQAHQQQGNKAEKAGSKEQGPRQRKGAAPAEKKCGAETQHEGLELRVENLQAVQTDFSSDPLQKVVCFNHDNTLLATGGTDGYVRVWKVPSLEKVLEFKAHEGEIEDLALGPDGKLVTVGRDLKASVWQKDQLVTQLHWQENGPTFSSTPYRYQACRFGQVPDQPAGLRLFTVQIPHKRLRQPPPCYLTAWDGSNFLPLRTKSCGHEVVSCLDVSESGTFLGLGTVTGSVAIYIAFSLQCLYYVREAHGIVVTDVAFLPEKGRGPELLGSHETALFSVAVDSRCQLHLLPSRRSVPVWLLLLLCVGLIIVTILLLQSAFPGFL
uniprot
proteins
function
FUNCTION: Guanine nucleotide exchange factor (GEF) that regulates the assembly of the coat protein complex II/COPII in endoplasmic reticulum (ER) to Golgi vesicle-mediated transport. Selectively activates SAR1A and SAR1B by promoting the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP) in these small GTPases (PubMed:32358066). In their activated GTP-bound state, SAR1A and SAR1B insert into the membrane of the endoplasmic reticulum where they recruit the remainder of the coat protein complex II/COPII which is responsible for both the sorting of proteins and the deformation and budding of membranes into vesicles destined to the Golgi (PubMed:32358066). {ECO:0000269|PubMed:32358066}.; FUNCTION: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription. {ECO:0000250|UniProtKB:Q9WTV0}.
uniprot
proteins
mass_dalton
45468
uniprot
proteins
pubmed
10920239
uniprot
proteins
pubmed
12735795
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25202031
uniprot
proteins
pubmed
27170179
uniprot
proteins
pubmed
28442536
uniprot
proteins
pubmed
32358066
uniprot
proteins
sequence_length
417
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9WTV0}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9WTV0}. Nucleus {ECO:0000250|UniProtKB:Q9WTV0}. Note=Concentrates at endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). {ECO:0000269|PubMed:25202031, ECO:0000269|PubMed:28442536}.
uniprot
proteins
transmembrane_region
TRANSMEM 389..409; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins