Havcr1
entrez
171283
canonical
uniprot
Q5QNS5
canonical
ensembl
ENSMUSG00000040405
resolver
ensp
ENSMUSP00000043827
resolver
ensp
ENSMUSP00000080503
resolver
ensp
ENSMUSP00000104846
resolver
enst
ENSMUST00000047568
resolver
enst
ENSMUST00000081819
resolver
enst
ENSMUST00000109223
resolver
genesymbol
Havcr1
resolver
genesymbol_syn
Kim1
resolver
genesymbol_syn
Tim1
resolver
genesymbol_syn
Timd1
resolver
uniprot
A0A0A0MQ86
resolver
uniprot
F7BLY6
resolver
uniprot
Q3V033
resolver
uniprot
Q7TPU2
resolver
uniprot
Q8VIM1
resolver
uniprot
Q8VIM2
resolver
uniprot_entry
A0A0A0MQ86_MOUSE
resolver
uniprot_entry
F7BLY6_MOUSE
resolver
uniprot_entry
HAVR1_MOUSE
resolver
uniprot_entry
Q3V033_MOUSE
resolver
uniprot_sec
Q7TPU2
resolver
uniprot_sec
Q8VIM1
resolver
uniprot_sec
Q8VIM2
resolver
amino_acid_sequence
MNQIQVFISGLILLLPGAVDSYVEVKGVVGHPVTLPCTYSTYRGITTTCWGRGQCPSSACQNTLIWTNGHRVTYQKSSRYNLKGHISEGDVSLTIENSVESDSGLYCCRVEIPGWFNDQKVTFSLQVKPEIPTRPPTRPTTTRPTATGRPTTISTRSTHVPTSIRVSTSTPPTSTHTWTHKPEPTTFCPHETTAEVTGIPSHTPTDWNGTVTSSGDTWSNHTEAIPPGKPQKNPTKGFYVGICIAALLLLLLVSTVAITRYILMKRKSASLSVVAFRVSKIEALQNAAVVHSRAEDNIYIVEDRP
uniprot
proteins
function
FUNCTION: Phosphatidylserine receptor that plays an important functional role in regulatory B-cell homeostasis including generation, expansion and suppressor functions (PubMed:21821911, PubMed:25645598, PubMed:32668241). Involved in efferocytosis, the process by which apoptotic cells are removed, by binding to phosphatidylserine present on apoptotic cells and promoting their engulfment (By similarity). Confers phagocytic ability on injured kidney epithelial cells, allowing them to bind to and internalize apoptotic bodies and necrotic debris following kidney injury (By similarity). The ectodomain binds to the surface of apoptotic kidney epithelial cells via phosphatidylserine and oxidized phospholipids exposed on the cell membrane of the apoptotic cells (By similarity). HAVCR1-expressing cells are also capable of phagocytosing Gram-negative and Gram-positive bacteria (By similarity). As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses (PubMed:24703780). Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease (PubMed:24703780). Acts as a regulator of T-cell proliferation (PubMed:15793576). Also regulates expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10 (PubMed:25582854, PubMed:25645598). {ECO:0000250|UniProtKB:Q96D42, ECO:0000269|PubMed:15793576, ECO:0000269|PubMed:21821911, ECO:0000269|PubMed:24703780, ECO:0000269|PubMed:25582854, ECO:0000269|PubMed:25645598, ECO:0000269|PubMed:32668241}.
uniprot
proteins
mass_dalton
33361
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
protein_family
TIM family
uniprot
proteins
pubmed
11725301
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15793576
uniprot
proteins
pubmed
17363299
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21821911
uniprot
proteins
pubmed
24703780
uniprot
proteins
pubmed
25582854
uniprot
proteins
pubmed
25645598
uniprot
proteins
pubmed
26726878
uniprot
proteins
pubmed
32668241
uniprot
proteins
sequence_length
305
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q96D42}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:Q96D42}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q96D42}.
uniprot
proteins
transmembrane_region
TRANSMEM 238..258; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins