Nenf
entrez
66208
canonical
uniprot
Q9CQ45
canonical
ensembl
ENSMUSG00000037499
resolver
ensp
ENSMUSP00000046311
resolver
enst
ENSMUST00000046770
resolver
genesymbol
Nenf
resolver
genesymbol_syn
Spuf
resolver
uniprot
Q5TM91
resolver
uniprot_entry
NENF_MOUSE
resolver
uniprot_sec
Q5TM91
resolver
amino_acid_sequence
MARPAPWWRLRLLAALVLALALVPVPSAWAGQTPRPAERGPPVRLFTEEELARYGGEEEDQPIYLAVKGVVFDVTSGKEFYGRGAPYNALAGKDSSRGVAKMSLDPADLTHDTTGLTAKELEALDDVFSKVYKAKYPIVGYTARRILNEDGSPNLDFKPEDQPHFDIKDEF
uniprot
proteins
function
FUNCTION: Acts as a neurotrophic factor in postnatal mature neurons, enhancing neuronal survival (PubMed:15605373, PubMed:31536960). Promotes cell proliferation and neurogenesis in undifferentiated neural pro-genitor cells at the embryonic stage and inhibits differentiation of astrocytes (PubMed:16547973). Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways (PubMed:15605373, PubMed:16547973). Neurotrophic activity is enhanced by binding to heme (PubMed:18056703). Also acts as an anorexigenic neurotrophic factor that contributes to energy balance (PubMed:23576617). {ECO:0000269|PubMed:15605373, ECO:0000269|PubMed:16547973, ECO:0000269|PubMed:18056703, ECO:0000269|PubMed:23576617, ECO:0000269|PubMed:31536960}.
uniprot
proteins
mass_dalton
18904
uniprot
proteins
mutagenesis
MUTAGEN 73..125; /note="Missing: Does not bind heme."; /evidence="ECO:0000269|PubMed:18056703
uniprot
proteins
protein_family
Cytochrome b5 family
uniprot
proteins
protein_family
MAPR subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15605373
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16547973
uniprot
proteins
pubmed
18056703
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576617
uniprot
proteins
pubmed
31536960
uniprot
proteins
sequence_length
171
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000269|PubMed:15605373}. Mitochondrion {ECO:0000269|PubMed:31536960}. Endoplasmic reticulum {ECO:0000269|PubMed:31536960}. Note=Localized to mitochondria and endoplasmic reticulum by PINK1 and PARK7. {ECO:0000250|UniProtKB:Q9UMX5}.
uniprot
proteins