Reep6
entrez
70335
canonical
uniprot
Q9JM62
canonical
ensembl
ENSMUSG00000035504
resolver
ensp
ENSMUSP00000100991
resolver
ensp
ENSMUSP00000100992
resolver
ensp
ENSMUSP00000100995
resolver
genesymbol
Reep6
resolver
genesymbol_syn
Dp1l1
resolver
genesymbol_syn
Tb2l1
resolver
uniprot
Q8K0X2
resolver
uniprot_entry
REEP6_MOUSE
resolver
uniprot_sec
Q8K0X2
resolver
amino_acid_sequence
MDGLRQRFERFLEQKNVATEALGALEARTGVEKRYLAAGALALLGLYLLFGYGASLLCNVIGFVYPAYASVKAIESPSKEDDTVWLTYWVVYALFGLVEFFSDLLLFWFPFYYAGKCAFLLFCMTPGPWNGALLLYHRVIRPLFLKHHMALDSAASQLSGRALDLAAGITRDVLQALARGRALVTPASTSEPPAALELDPK
uniprot
proteins
function
FUNCTION: Required for correct function and survival of retinal photoreceptors (PubMed:24098485, PubMed:24691551, PubMed:28475715). Required for retinal development (PubMed:28369466). In rod photoreceptors, facilitates stability and/or trafficking of guanylate cyclases and is required to maintain endoplasmic reticulum and mitochondrial homeostasis (PubMed:28475715). May play a role in clathrin-coated intracellular vesicle trafficking of proteins from the endoplasmic reticulum to the retinal rod plasma membrane (PubMed:24098485, PubMed:28369466). {ECO:0000269|PubMed:24098485, ECO:0000269|PubMed:24691551, ECO:0000269|PubMed:28369466, ECO:0000269|PubMed:28475715}.
uniprot
proteins
mass_dalton
22204
uniprot
proteins
protein_family
DP1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15550249
uniprot
proteins
pubmed
15728532
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24098485
uniprot
proteins
pubmed
24691551
uniprot
proteins
pubmed
28369466
uniprot
proteins
pubmed
28475715
uniprot
proteins
sequence_length
201
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:24098485, ECO:0000269|PubMed:28475715}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269|PubMed:28369466}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..56; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 89..109; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 117..137; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins