PDE8A
entrez
5151
canonical
uniprot
O60658
canonical
ensembl
ENSG00000073417
resolver
ensp
ENSP00000340679
resolver
ensp
ENSP00000378056
resolver
ensp
ENSP00000453808
resolver
ensp
ENSP00000779379
resolver
genesymbol
PDE8A
resolver
hgnc
HGNC:8793
resolver
uniprot
B3KXE6
resolver
uniprot
H0YMZ7
resolver
uniprot
Q6P9H3
resolver
uniprot
Q969I1
resolver
uniprot
Q96PC9
resolver
uniprot
Q96PD0
resolver
uniprot
Q96PD1
resolver
uniprot
Q96T71
resolver
uniprot
Q9UMB7
resolver
uniprot
Q9UMC3
resolver
uniprot_entry
PDE8A_HUMAN
resolver
uniprot_sec
B3KXE6
resolver
uniprot_sec
H0YMZ7
resolver
uniprot_sec
Q6P9H3
resolver
uniprot_sec
Q969I1
resolver
uniprot_sec
Q96PC9
resolver
uniprot_sec
Q96PD0
resolver
uniprot_sec
Q96PD1
resolver
uniprot_sec
Q96T71
resolver
uniprot_sec
Q9UMB7
resolver
uniprot_sec
Q9UMC3
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by dipyridimole. Insensitive to selective PDE inhibitors including rolipram and zaprinast as well as to the non-selective inhibitor, IBMX. Unaffected by cGMP. {ECO:0000250|UniProtKB:O95263}.
uniprot
proteins
amino_acid_sequence
MGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGSGKKVAVADVQFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACFLDKHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRVDREELSVMPFISAGFTRRYVENPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENSEDAIEITSEDRFIQYANPAFETTMGYQSGELIGKELGEVPINEKKADLLDTINSCIRIGKEWQGIYYAKKKNGDNIQQNVKIIPVIGQGGKIRHYVSIIRVCNGNNKAEKISECVQSDTHTDNQTGKHKDRRKGSLDVKAVASRATEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVLEILRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNTQMVSSNIITPISLDDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRSWLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDHPGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQGIIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRMLIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQISFIDYFITDMFDAWDAFVDLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE
uniprot
proteins
ec_number
3.1.4.53
uniprot
proteins
function
FUNCTION: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167). May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167). Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed:23509299). Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299). {ECO:0000269|PubMed:18983167, ECO:0000269|PubMed:23509299}.
uniprot
proteins
mass_dalton
93304
uniprot
proteins
mutagenesis
MUTAGEN 454..455; /note="RR->AA: Reduces interaction with RAF1; when associated with A-460 and A-461."; /evidence="ECO:0000269|PubMed:23509299"; MUTAGEN 460..461; /note="EY->AA: Reduces interaction with RAF1; when associated with A-454 and A-455."; /evidence="ECO:0000269|PubMed:23509299"; MUTAGEN 748; /note="Y->F: Increases sensitivity to several nonselective or family selective PDE inhibitors."; /evidence="ECO:0000269|PubMed:18983167
uniprot
proteins
pathway_participation
PATHWAY: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-359 by PKA under elevated cAMP conditions, this enhances catalytic activity. {ECO:0000269|PubMed:22673573}.
uniprot
proteins
protein_family
Cyclic nucleotide phosphodiesterase family
uniprot
proteins
protein_family
PDE8 subfamily
uniprot
proteins
pubmed
11371644
uniprot
proteins
pubmed
11738832
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
18983167
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
22673573
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23509299
uniprot
proteins
pubmed
9618252
uniprot
proteins
sequence_length
829
uniprot
proteins