AQP1
entrez
358
canonical
uniprot
P29972
canonical
ensembl
ENSG00000240583
resolver
ensp
ENSP00000311165
resolver
genesymbol
AQP1
resolver
genesymbol_syn
CHIP28
resolver
hgnc
HGNC:633
resolver
uniprot
B5BU39
resolver
uniprot
E7EM69
resolver
uniprot
E9PC21
resolver
uniprot
F5GY19
resolver
uniprot
Q8TBI5
resolver
uniprot
Q8TDC1
resolver
uniprot_entry
AQP1_HUMAN
resolver
uniprot_sec
B5BU39
resolver
uniprot_sec
E7EM69
resolver
uniprot_sec
E9PC21
resolver
uniprot_sec
F5GY19
resolver
uniprot_sec
Q8TBI5
resolver
uniprot_sec
Q8TDC1
resolver
activity_regulation
ACTIVITY REGULATION: The water channel activity is inhibited by P-choloromercuribenzene sulphonate and diethylpyrocarbonate(DPPC) (PubMed:8584435). The glycerol channel activity is inhibited by P-choloromercuribenzene sulphonate, diethylpyrocarbonate(DPPC), phloretin and Cu(2+) (PubMed:8584435). Inhibited by mercury (PubMed:7677994). {ECO:0000269|PubMed:7677994, ECO:0000269|PubMed:8584435}.
uniprot
proteins
amino_acid_sequence
MASEFKKKLFWRAVVAEFLATTLFVFISIGSALGFKYPVGNNQTAVQDNVKVSLAFGLSIATLAQSVGHISGAHLNPAVTLGLLLSCQISIFRALMYIIAQCVGAIVATAILSGITSSLTGNSLGRNDLADGVNSGQGLGIEIIGTLQLVLCVLATTDRRRRDLGGSAPLAIGLSVALGHLLAIDYTGCGINPARSFGSAVITHNFSNHWIFWVGPFIGGALAVLIYDFILAPRSSDLTDRVKVWTSGQVEEYDLDADDINSRVEMKPK
uniprot
proteins
function
FUNCTION: Forms a water channel that facilitates the transport of water across cell membranes, playing a crucial role in water homeostasis in various tissues (PubMed:1373524, PubMed:23219802). Could also be permeable to small solutes including hydrogen peroxide, glycerol and gases such as amonnia (NH3), nitric oxide (NO) and carbon dioxide (CO2) (PubMed:16682607, PubMed:17012249, PubMed:19273840, PubMed:33028705, PubMed:8584435). Recruited to the ankyrin-1 complex, a multiprotein complex of the erythrocyte membrane, it could be part of a CO2 metabolon, linking facilitated diffusion of CO2 across the membrane, anion exchange of Cl(-)/HCO3(-) and interconversion of dissolved CO2 and carbonic acid in the cytosol (PubMed:17012249, PubMed:35835865). In vitro, it shows non-selective gated cation channel activity and may be permeable to cations like K(+) and Na(+) in vivo (PubMed:36949749, PubMed:8703053). {ECO:0000269|PubMed:1373524, ECO:0000269|PubMed:16682607, ECO:0000269|PubMed:17012249, ECO:0000269|PubMed:19273840, ECO:0000269|PubMed:23219802, ECO:0000269|PubMed:33028705, ECO:0000269|PubMed:35835865, ECO:0000269|PubMed:36949749, ECO:0000269|PubMed:8584435, ECO:0000269|PubMed:8703053}.
uniprot
proteins
mass_dalton
28526
uniprot
proteins
mutagenesis
MUTAGEN 180; /note="H->A: No effect on water channel activity."; /evidence="ECO:0000269|PubMed:8584435"; MUTAGEN 189; /note="C->S: No effect on water channel activity."; /evidence="ECO:0000269|PubMed:8584435"; MUTAGEN 209; /note="H->A: Decreased water channel activity."; /evidence="ECO:0000269|PubMed:8584435
uniprot
proteins
protein_family
MIP/aquaporin (TC 1.A.8) family
uniprot
proteins
pubmed
11034202
uniprot
proteins
pubmed
11171962
uniprot
proteins
pubmed
11532455
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
1373524
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16682607
uniprot
proteins
pubmed
17012249
uniprot
proteins
pubmed
1722319
uniprot
proteins
pubmed
19054851
uniprot
proteins
pubmed
19273840
uniprot
proteins
pubmed
2007592
uniprot
proteins
pubmed
23219802
uniprot
proteins
pubmed
33028705
uniprot
proteins
pubmed
35835865
uniprot
proteins
pubmed
36949749
uniprot
proteins
pubmed
7507481
uniprot
proteins
pubmed
7517253
uniprot
proteins
pubmed
7518771
uniprot
proteins
pubmed
7521540
uniprot
proteins
pubmed
7521882
uniprot
proteins
pubmed
7677994
uniprot
proteins
pubmed
8340403
uniprot
proteins
pubmed
8584435
uniprot
proteins
pubmed
8703053
uniprot
proteins
pubmed
8703970
uniprot
proteins
pubmed
9177353
uniprot
proteins
sequence_length
269
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23219802}; Multi-pass membrane protein {ECO:0000269|PubMed:7507481}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..29; /note="Helical; Name=Helix 1"; /evidence="ECO:0000305|PubMed:35835865, ECO:0007744|PDB:8CT2"; TRANSMEM 47..65; /note="Helical; Name=Helix 2"; /evidence="ECO:0000305|PubMed:35835865, ECO:0007744|PDB:8CT2"; TRANSMEM 91..109; /note="Helical; Name=Helix 3"; /evidence="ECO:0000305|PubMed:35835865, ECO:0007744|PDB:8CT2"; TRANSMEM 134..153; /note="Helical; Name=Helix 4"; /evidence="ECO:0000305|PubMed:35835865, ECO:0007744|PDB:8CT2"; TRANSMEM 164..181; /note="Helical; Name=Helix 5"; /evidence="ECO:0000305|PubMed:35835865, ECO:0007744|PDB:8CT2"; TRANSMEM 207..224; /note="Helical; Name=Helix 6"; /evidence="ECO:0000305|PubMed:35835865, ECO:0007744|PDB:8CT2
uniprot
proteins