PLCD4
entrez
84812
canonical
uniprot
Q9BRC7
canonical
ensembl
ENSG00000115556
resolver
ensp
ENSP00000388631
resolver
ensp
ENSP00000396185
resolver
ensp
ENSP00000614102
resolver
enst
ENST00000432688
resolver
enst
ENST00000944043
resolver
genesymbol
PLCD4
resolver
hgnc
HGNC:9062
resolver
uniprot
C9JEA7
resolver
uniprot
Q53FS8
resolver
uniprot_entry
C9JEA7_HUMAN
resolver
uniprot_entry
PLCD4_HUMAN
resolver
uniprot_sec
Q53FS8
resolver
amino_acid_sequence
MASLLQDQLTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSELLRSLAEELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLVTSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQAADTSQSGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELALELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSHNTYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVATVAQYAFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQLPSPEELRRKILVKGKKLTLEEDLEYEEEEAEPELEESELALESQFETEPEPQEQNLQNKDKKKKSKPILCPALSSLVIYLKSVSFRSFTHSKEHYHFYEISSFSETKAKRLIKEAGNEFVQHNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCGYVLKPDFLRDIQSSFHPEKPISPFKAQTLLIQVISGQQLPKVDKTKEGSIVDPLVKVQIFGVRLDTARQETNYVENNGFNPYWGQTLCFRVLVPELAMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGYRHIHLLSKDGISLRPASIFVYICIQEGLEGDES
uniprot
proteins
ec_number
3.1.4.11
uniprot
proteins
function
FUNCTION: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation. {ECO:0000269|PubMed:15140260}.; FUNCTION: [Isoform 2]: Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G protein) alpha subunit GNAI3. {ECO:0000269|PubMed:30194280}.
uniprot
proteins
mass_dalton
87585
uniprot
proteins
mutagenesis
MUTAGEN 224..228; /note="LLEFL->ALEAA: Abolishes binding to and activation of GNAI3."; /evidence="ECO:0000269|PubMed:30194280"; MUTAGEN 227..228; /note="FL->AA: Abolishes binding to GNAI3."; /evidence="ECO:0000269|PubMed:30194280"; MUTAGEN 227; /note="F->A: Marked but incomplete decrease in GNAI3 binding and reduced activation of G protein signaling."; /evidence="ECO:0000269|PubMed:30194280
uniprot
proteins
pubmed
10702683
uniprot
proteins
pubmed
15140260
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15505048
uniprot
proteins
pubmed
30194280
uniprot
proteins
sequence_length
762
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q62711}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q62711}; Cytoplasmic side {ECO:0000250|UniProtKB:Q62711}. Nucleus {ECO:0000250|UniProtKB:Q62711}. Cytoplasm {ECO:0000269|PubMed:15140260}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q62711}. Note=The C2 domain mediates pre-localization to the membrane prior to Ca(2+) import and non-selective Ca(2+)-mediated targeting to various cellular membranes (By similarity). Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:Q62711}.
uniprot
proteins