POLR3F
entrez
10621
canonical
uniprot
Q9H1D9
canonical
ensembl
ENSG00000132664
resolver
ensp
ENSP00000366828
resolver
ensp
ENSP00000513372
resolver
ensp
ENSP00000513375
resolver
ensp
ENSP00000513376
resolver
ensp
ENSP00000513383
resolver
ensp
ENSP00000662284
resolver
enst
ENST00000377603
resolver
enst
ENST00000462997
resolver
enst
ENST00000697649
resolver
enst
ENST00000697652
resolver
enst
ENST00000697658
resolver
genesymbol
POLR3F
resolver
hgnc
HGNC:15763
resolver
uniprot
A0A8V8TL53
resolver
uniprot
A0A8V8TMJ2
resolver
uniprot
A0A8V8TMS0
resolver
uniprot
A8K4C7
resolver
uniprot
O15319
resolver
uniprot
Q05DB8
resolver
uniprot_entry
A0A8V8TL53_HUMAN
resolver
uniprot_entry
A0A8V8TMJ2_HUMAN
resolver
uniprot_entry
A0A8V8TMS0_HUMAN
resolver
uniprot_entry
Q05DB8_HUMAN
resolver
uniprot_entry
RPC6_HUMAN
resolver
uniprot_sec
A8K4C7
resolver
uniprot_sec
O15319
resolver
amino_acid_sequence
MAEVKVKVQPPDADPVEIENRIIELCHQFPHGITDQVIQNEMPHIEAQQRAVAINRLLSMGQLDLLRSNTGLLYRIKDSQNAGKMKGSDNQEKLVYQIIEDAGNKGIWSRDIRYKSNLPLTEINKILKNLESKKLIKAVKSVAASKKKVYMLYNLQPDRSVTGGAWYSDQDFESEFVEVLNQQCFKFLQSKAETARESKQNPMIQRNSSFASSHEVWKYICELGISKVELSMEDIETILNTLIYDGKVEMTIIAAKEGTVGSVDGHMKLYRAVNPIIPPTGLVRAPCGLCPVFDDCHEGGEISPSNCIYMTEWLEF
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency 101, varicella zoster virus-specific (IMD101) [MIM:619872]: An autosomal dominant immunologic disorder characterized by reactivation of varicella zoster virus (VZV) infection in adulthood after primary childhood infection with VZV. The viral reactivation manifests as central nervous system vasculitis with stroke-like episodes and lacunar infarcts on brain imaging. Features include headache, hemiparesis, impaired balance, and other neurologic signs. {ECO:0000269|PubMed:30211253}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:20413673, PubMed:21358628, PubMed:33558764, PubMed:34675218). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Part of POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer that coordinates the dynamics of Pol III stalk and clamp modules during the transition from apo to elongation state (PubMed:20413673, PubMed:33558764, PubMed:33558766). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses, including varicella zoster virus. Acts as a nuclear and cytosolic DNA sensor detecting AT-rich DNA, involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370, PubMed:30211253). Preferentially binds double-stranded DNA (dsDNA) (PubMed:21358628). {ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:21358628, ECO:0000269|PubMed:30211253, ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:33558766, ECO:0000269|PubMed:34675218}.
uniprot
proteins
mass_dalton
35684
uniprot
proteins
mutagenesis
MUTAGEN 137..140; /note="KAVK->EAVE: Strongly impaired dsDNA-binding. No effect on interaction with POLR3C."; /evidence="ECO:0000269|PubMed:21358628"; MUTAGEN 173..175; /note="ESE->KSK: Strongly impaired dsDNA-binding. No effect on interaction with POLR3C."; /evidence="ECO:0000269|PubMed:21358628
uniprot
proteins
protein_family
Eukaryotic RPC34/RPC39 RNA polymerase subunit family
uniprot
proteins
pubmed
10523658
uniprot
proteins
pubmed
11416169
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12391170
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18377933
uniprot
proteins
pubmed
19609254
uniprot
proteins
pubmed
19631370
uniprot
proteins
pubmed
20413673
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21358628
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
30211253
uniprot
proteins
pubmed
33335104
uniprot
proteins
pubmed
33558764
uniprot
proteins
pubmed
33558766
uniprot
proteins
pubmed
33674783
uniprot
proteins
pubmed
34675218
uniprot
proteins
pubmed
9171375
uniprot
proteins
sequence_length
316
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:33335104}.
uniprot
proteins