Mcoln2
entrez
68279
canonical
uniprot
Q8K595
canonical
ensembl
ENSMUSG00000011008
resolver
ensp
ENSMUSP00000011152
resolver
ensp
ENSMUSP00000096125
resolver
ensp
ENSMUSP00000193488
resolver
genesymbol
Mcoln2
resolver
uniprot
Q3UCG4
resolver
uniprot
Q8K2T6
resolver
uniprot
Q9CQD3
resolver
uniprot_entry
MCLN2_MOUSE
resolver
uniprot_sec
Q3UCG4
resolver
uniprot_sec
Q8K2T6
resolver
uniprot_sec
Q9CQD3
resolver
activity_regulation
ACTIVITY REGULATION: [Isoform 2]: Fe(2+) channel activity is potentiated by low pH. {ECO:0000269|PubMed:18794901}.
uniprot
proteins
amino_acid_sequence
MPGDEETLDLPAWNRVPDLTWGPHHRSAMASLDSEVREECLREDLKFYFMSPCEKYRARRQIPWKLGLQILKIVMVTTQLVRFGLSNQLVVAFKEDNTVAFKHLFLKGFSGVDEDDYSCSIYTQENTYESIFFAIKQYRHLKNISLATLGYGESEDNRTGLKVCKQHYKTGAMFSSNETLNIDSDIETDCIHLDLQVLTTEPEDWAQTSFFRLDFYRLVQVDISFALKGIDLQAVHSREIPDCYLFQNTITFDNTAHSGKIKIYLNSEANIEECKNMNISGSTQRSTHYLLVFDVFVIMICLASLILCTRSIVLALRLRKRFLNFFLEKYKQRVCGADQWEFVNGWYVLVTISDLMTIIGSILKMEIKAKKLTNYDVCSILLGTSTLFVWVGVIRYLGYFQTYNVLILTMQASLPKVLRFCACAGMIYLGYTFCGWIVLGPYHEKFENLNIVAECLFSLVNGDDMFATFAQIQQKSILVWLFSRLYLYSFISLFIYMVLSLFIALITDSYHTIKKYQQHGFPETDLQKFLKESGSKDGYQKQPSALLSCLCCLRRRRSNDHLILID
uniprot
proteins
function
FUNCTION: Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:19763610). May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway (By similarity). May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (PubMed:17050035). In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration (PubMed:26432893). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events. Also functions as a Fe(2+) permeable channel (PubMed:18794901). {ECO:0000250|UniProtKB:Q8IZK6, ECO:0000269|PubMed:17050035, ECO:0000269|PubMed:18794901, ECO:0000269|PubMed:19763610, ECO:0000269|PubMed:22753890, ECO:0000269|PubMed:26432893, ECO:0000305}.
uniprot
proteins
mass_dalton
65450
uniprot
proteins
mutagenesis
MUTAGEN 424; /note="A->P: Constitutive active channel that mediates strong inwardly rectifying current."; /evidence="ECO:0000269|PubMed:18794901
uniprot
proteins
protein_family
MCOLN2 sub-subfamily
uniprot
proteins
protein_family
Polycystin subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
pubmed
12403827
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17050035
uniprot
proteins
pubmed
18794901
uniprot
proteins
pubmed
19763610
uniprot
proteins
pubmed
22753890
uniprot
proteins
pubmed
26432893
uniprot
proteins
sequence_length
566
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8IZK6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F6RG56}. Lysosome membrane {ECO:0000305|PubMed:17050035}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F6RG56}. Recycling endosome membrane {ECO:0000269|PubMed:26432893}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F6RG56}. Note=Localizes to recycling endosomes in activated macrophages and microglia. {ECO:0000269|PubMed:26432893}.
uniprot
proteins
transmembrane_region
TRANSMEM 66..86; /note="Helical"; /evidence="ECO:0000250|UniProtKB:F6RG56"; TRANSMEM 289..309; /note="Helical"; /evidence="ECO:0000250|UniProtKB:F6RG56"; TRANSMEM 347..367; /note="Helical"; /evidence="ECO:0000250|UniProtKB:F6RG56"; TRANSMEM 377..397; /note="Helical"; /evidence="ECO:0000250|UniProtKB:F6RG56"; TRANSMEM 420..440; /note="Helical"; /evidence="ECO:0000250|UniProtKB:F6RG56"; TRANSMEM 481..502; /note="Helical"; /evidence="ECO:0000250|UniProtKB:F6RG56
uniprot
proteins