Phospho1
entrez
237928
canonical
uniprot
Q8R2H9
canonical
ensembl
ENSMUSG00000050860
resolver
ensp
ENSMUSP00000057858
resolver
enst
ENSMUST00000054173
resolver
genesymbol
Phospho1
resolver
uniprot
A2A619
resolver
uniprot_entry
PHOP1_MOUSE
resolver
uniprot_sec
A2A619
resolver
amino_acid_sequence
MSGCFPAVGLRCLSRDGRMAAPGAPRFLLTFDFDETIVDENSDDSIVRAAPGQQLPESLRATYREGYYNEYMQRVFKYLGEQGVRPRDLRAVYETIPLSPGMGDLLQFIAKQGSCFEVILISDANTFGVESALRAAGHHSLFRRILSNPSGPDARGLLTLRPFHTHSCSRCPANMCKHKVLSEYLRERARDGVHFERLFYVGDGANDFCPMGLLAGGDVAFPRRGYPMHRLIQEAQKAEPSSFRAHVVPWETAADVRQHLQQVLKMC
uniprot
proteins
ec_number
3.1.3.75
uniprot
proteins
function
FUNCTION: Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho) (By similarity). Involved in the generation of inorganic phosphate for bone mineralization (PubMed:17227223). Acts in a non-redundant manner with PHOSPHO1 in skeletal mineralization: while PHOSPHO1 mediates the initiation of hydroxyapatite crystallization in the matrix vesicles (MVs), ALPL/TNAP catalyzes the spread of hydroxyapatite crystallization in the extracellular matrix (PubMed:20684022, PubMed:26457330). {ECO:0000250|UniProtKB:Q8TCT1, ECO:0000269|PubMed:17227223, ECO:0000269|PubMed:20684022, ECO:0000269|PubMed:26457330}.
uniprot
proteins
mass_dalton
29911
uniprot
proteins
protein_family
HAD-like hydrolase superfamily
uniprot
proteins
protein_family
PHOSPHO family
uniprot
proteins
pubmed
12464021
uniprot
proteins
pubmed
17227223
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20684022
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26457330
uniprot
proteins
sequence_length
267
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Extracellular vesicle {ECO:0000269|PubMed:17227223}. Note=Localizes to special class of extracellular vesicles, named matrix vesicles (MVs), which are released by osteogenic cells. {ECO:0000269|PubMed:17227223}.
uniprot
proteins