Hvcn1
entrez
74096
canonical
uniprot
Q3U2S8
canonical
ensembl
ENSMUSG00000064267
resolver
ensp
ENSMUSP00000072401
resolver
ensp
ENSMUSP00000098312
resolver
ensp
ENSMUSP00000299256
resolver
ensp
ENSMUSP00000339241
resolver
enst
ENSMUST00000072602
resolver
enst
ENSMUST00000100747
resolver
genesymbol
Hvcn1
resolver
genesymbol_syn
Bts
resolver
genesymbol_syn
Vsop
resolver
uniprot
Q9DCE4
resolver
uniprot_entry
HVCN1_MOUSE
resolver
uniprot_sec
Q9DCE4
resolver
activity_regulation
ACTIVITY REGULATION: The dimers display cooperative channel gating. The channel activity is inhibited by zinc ions. {ECO:0000269|PubMed:16556803, ECO:0000269|PubMed:19805063, ECO:0000269|PubMed:22569364, ECO:0000269|PubMed:24584463}.
uniprot
proteins
amino_acid_sequence
MTSHDPKAVTRRTKVAPTKRMSRFLKHFTVVGDDYHTWNVNYKKWENEEEEEEPAPTSAEGEGNAEGPDAEAGSASTPRQSLDFRSRLRKLFSSHRFQVIIICLVVLDALLVLAELLLDLKIIEPDEQDYAVTAFHYMSFAILVFFMLEIFFKIFVFRLEFFHHKFEILDAFVVVVSFVLDLVLLFKSHHFEALGLLILLRLWRVARIINGIIISVKTRSERQILRLKQINIQLATKIQHLEFSCSEKEQEIERLNKLLKQNGLLGDVN
uniprot
proteins
function
FUNCTION: Voltage-gated proton-selective channel that conducts outward proton currents in response to intracellular acidification. Lacks a canonical ion-channel pore domain and mediates proton permeability via its voltage sensor domain (PubMed:16556803, PubMed:19805063, PubMed:22569364, PubMed:23165764, PubMed:24584463). Provides for proton efflux that compensates for electron charge generated by NADPH oxidase activity either in the extracellular or phagosomal compartments, thus enabling the production of high levels of bactericidal reactive oxygen species during the respiratory burst (PubMed:19805063, PubMed:20026664, PubMed:24415791). Opens when the pH of airway surface liquid exceeds 7 and contributes to respiratory epithelial acid secretion to maintain pH in the mucosa (By similarity). {ECO:0000250|UniProtKB:Q96D96, ECO:0000269|PubMed:16556803, ECO:0000269|PubMed:19805063, ECO:0000269|PubMed:20026664, ECO:0000269|PubMed:22569364, ECO:0000269|PubMed:23165764, ECO:0000269|PubMed:24415791, ECO:0000269|PubMed:24584463}.
uniprot
proteins
mass_dalton
31242
uniprot
proteins
mutagenesis
MUTAGEN 201; /note="R->Q: Faster channel activation kinetics."; /evidence="ECO:0000269|PubMed:16556803"; MUTAGEN 207; /note="R->Q: Same activation kinetics as wild-type."; /evidence="ECO:0000269|PubMed:16556803"; MUTAGEN 216..218; /note="VKT->GGG: Impairs gating cooperativity."; /evidence="ECO:0000269|PubMed:22569364"; MUTAGEN 230..232; /note="INI->NIN: Slows channel activation."; /evidence="ECO:0000269|PubMed:22569364"; MUTAGEN 231; /note="N->L: No effect on channel activation kinetics."; /evidence="ECO:0000269|PubMed:22569364
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in vitro by PRKCD. Phosphorylation may enhance channel gating. {ECO:0000250|UniProtKB:Q96D96}.
uniprot
proteins
protein_family
Voltage-gated proton channel (VPC) (TC 1.A.51) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16556803
uniprot
proteins
pubmed
19805063
uniprot
proteins
pubmed
20026664
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22569364
uniprot
proteins
pubmed
23165764
uniprot
proteins
pubmed
24415791
uniprot
proteins
pubmed
24584463
uniprot
proteins
pubmed
37669933
uniprot
proteins
sequence_length
269
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q96D96}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q96D96}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome membrane {ECO:0000269|PubMed:24415791}; Multi-pass membrane protein {ECO:0000255}. Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:Q96D96}; Multi-pass membrane protein {ECO:0000255}. Note=Detected within the principal piece of the sperm flagellum. {ECO:0000250|UniProtKB:Q96D96}.
uniprot
proteins
transmembrane_region
TRANSMEM 97..117; /note="Helical; Name=Segment S1"; TRANSMEM 135..157; /note="Helical; Name=Segment S2"; TRANSMEM 166..186; /note="Helical; Name=Segment S3"; TRANSMEM 194..214; /note="Helical; Name=Segment S4
uniprot
proteins