Reck
entrez
53614
canonical
uniprot
Q9Z0J1
canonical
ensembl
ENSMUSG00000028476
resolver
ensp
ENSMUSP00000030198
resolver
enst
ENSMUST00000030198
resolver
genesymbol
Reck
resolver
uniprot
A2RSP9
resolver
uniprot
B1AWM3
resolver
uniprot_entry
A2RSP9_MOUSE
resolver
uniprot_entry
RECK_MOUSE
resolver
uniprot_sec
B1AWM3
resolver
amino_acid_sequence
MASVRASPRSALLLLLAAAGVAEVTGGLAPGSAGAVCCNHSKDNQMCRDVCEQIFSSKSESRLKHLLQRAPDYCPETMVEIWSCMNSSLPGVFKKSDGWVGLGCCELAIGLECRQACKQASSKNDISKVCRKEYENALFSCISRNEMGSVCCSYAGHHTNCREFCQAIFRTDSSPGPSQIKAVENYCASISPQLIHCVNNYTQSYPMRNPTDSLYCCDRAEDHACQNACKRILMSKKTEMEIVDGLIEGCKTQPLPQDPLWQCFLESSQSVHPGVTVHPPPSTGLDGAKLHCCSKANTSTCRELCTKLYSMSWGNTQSWQEFDRICEYNPVEVSMLTCLADVREPCQLGCTNLTYCTNFNNRPTELFRSCTAQSDQGAMSDMKLWEKGSIKMPFISIPVLDIKTCQPEMWKAVACSLQIKPCHSKSRGSIICKSDCVEILKKCGDQNKFPEEHTAESICEFLSPADDLESCIPLDTYLRPSALGNIIEEVTHPCNPNPCPANELCEVNRKGCPSADPCLPYSCVQGCKLGEASDFIVRQGTLIQVPSSAGEVGCYKICSCGQSGLLENCMEMHCIDLQKSCIVGGKRKSHGTSFTIDCNVCSCFAGNLVCSTRLCLSEHSSDDDRRTFTGLPCNCADQFVPVCAQNGRTYPSACIARCVGLQDHQFEFGPCISKNPCNPNLCPKSQRCVPKPQVCLTTFDKFGCSQYECVPRQLTCDQARDPVCDTDHMEHSNLCTLYQRGKSLSYRGPCQPFCRAKEPVCGHNGETYSSVCAAYSDRVAVDYYGPCQAVGVLSEYSAVAECAAVKCPSLSAIGCKPIIPPGACCPLCAGMLRVLFDKEKLDTIAKVTSKKPITVVEILQKVRMHVSVPQCDVFGYLSIESEIVILIIPVDHYPKALQIEACNKEAEKIESLINSDSPTLASHVPLSALIISQVQVSSSLPSSAVVGRPLFHSLLLLLSLGLTVHLLWTRP
uniprot
proteins
function
FUNCTION: Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28803732). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (PubMed:26658478, PubMed:28803732). Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7 (By similarity). ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (By similarity). Also acts as a serine protease inhibitor: negatively regulates matrix metalloproteinase-9 (MMP9) by suppressing MMP9 secretion and by direct inhibition of its enzymatic activity (PubMed:11747814). Also inhibits metalloproteinase activity of MMP2, MMP14 (MT1-MMP) and ADAM10 (PubMed:11747814, PubMed:33731436). {ECO:0000250|UniProtKB:O95980, ECO:0000269|PubMed:11747814, ECO:0000269|PubMed:26658478, ECO:0000269|PubMed:28803732, ECO:0000269|PubMed:33731436}.
uniprot
proteins
mass_dalton
106082
uniprot
proteins
mutagenesis
MUTAGEN 68; /note="Q->A: Does not affect interaction with ADGRA2."; /evidence="ECO:0000269|PubMed:28803732"; MUTAGEN 69; /note="R->A: Decreased interaction with ADGRA2."; /evidence="ECO:0000269|PubMed:28803732"; MUTAGEN 71; /note="P->A: Decreased interaction with ADGRA2."; /evidence="ECO:0000269|PubMed:28803732"; MUTAGEN 72; /note="D->A: Does not affect interaction with ADGRA2."; /evidence="ECO:0000269|PubMed:28803732"; MUTAGEN 73; /note="Y->A: Decreased interaction with ADGRA2."; /evidence="ECO:0000269|PubMed:28803732
uniprot
proteins
post_translational_modification
PTM: GPI-anchored. Cleavage of the GPI-anchor by GDPD5 and release of RECK from the plasma membrane negatively regulates its activity toward ADAM10. {ECO:0000269|PubMed:33731436}.
uniprot
proteins
protein_family
RECK family
uniprot
proteins
pubmed
11747814
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26658478
uniprot
proteins
pubmed
28803732
uniprot
proteins
pubmed
33731436
uniprot
proteins
pubmed
9789069
uniprot
proteins
sequence_length
971
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28803732}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:O95980}.
uniprot
proteins