MCM6
entrez
4175
canonical
uniprot
Q14566
canonical
ensembl
ENSG00000076003
resolver
ensp
ENSP00000264156
resolver
enst
ENST00000264156
resolver
genesymbol
MCM6
resolver
hgnc
HGNC:6949
resolver
uniprot
B2R6H2
resolver
uniprot
Q13504
resolver
uniprot
Q99859
resolver
uniprot_entry
MCM6_HUMAN
resolver
uniprot_sec
B2R6H2
resolver
uniprot_sec
Q13504
resolver
uniprot_sec
Q99859
resolver
amino_acid_sequence
MDLAAAAEPGAGSQHLEVRDEVAEKCQKLFLDFLEEFQSSDGEIKYLQLAEELIRPERNTLVVSFVDLEQFNQQLSTTIQEEFYRVYPYLCRALKTFVKDRKEIPLAKDFYVAFQDLPTRHKIRELTSSRIGLLTRISGQVVRTHPVHPELVSGTFLCLDCQTVIRDVEQQFKYTQPNICRNPVCANRRRFLLDTNKSRFVDFQKVRIQETQAELPRGSIPRSLEVILRAEAVESAQAGDKCDFTGTLIVVPDVSKLSTPGARAETNSRVSGVDGYETEGIRGLRALGVRDLSYRLVFLACCVAPTNPRFGGKELRDEEQTAESIKNQMTVKEWEKVFEMSQDKNLYHNLCTSLFPTIHGNDEVKRGVLLMLFGGVPKTTGEGTSLRGDINVCIVGDPSTAKSQFLKHVEEFSPRAVYTSGKASSAAGLTAAVVRDEESHEFVIEAGALMLADNGVCCIDEFDKMDVRDQVAIHEAMEQQTISITKAGVKATLNARTSILAAANPISGHYDRSKSLKQNINLSAPIMSRFDLFFILVDECNEVTDYAIARRIVDLHSRIEESIDRVYSLDDIRRYLLFARQFKPKISKESEDFIVEQYKHLRQRDGSGVTKSSWRITVRQLESMIRLSEAMARMHCCDEVQPKHVKEAFRLLNKSIIRVETPDVNLDQEEEIQMEVDEGAGGINGHADSPAPVNGINGYNEDINQESAPKASLRLGFSEYCRISNLIVLHLRKVEEEEDESALKRSELVNWYLKEIESEIDSEEELINKKRIIEKVIHRLTHYDHVLIELTQAGLKGSTEGSESYEEDPYLVVNPNYLLED
uniprot
proteins
ec_number
3.6.4.12
uniprot
proteins
function
FUNCTION: Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). {ECO:0000269|PubMed:16899510, ECO:0000269|PubMed:32453425, ECO:0000269|PubMed:34694004, ECO:0000269|PubMed:34700328, ECO:0000269|PubMed:35585232, ECO:0000269|PubMed:9305914}.
uniprot
proteins
mass_dalton
92889
uniprot
proteins
mutagenesis
MUTAGEN 757; /note="E->A,D: Impairs interaction with CTD1."; /evidence="ECO:0000269|PubMed:20202939"; MUTAGEN 763; /note="E->A,D: Impairs interaction with CTD1."; /evidence="ECO:0000269|PubMed:20202939"; MUTAGEN 766; /note="L->A: Impairs interaction with CTD1."; /evidence="ECO:0000269|PubMed:20202939
uniprot
proteins
post_translational_modification
PTM: O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. {ECO:0000269|PubMed:22967762}.
uniprot
proteins
protein_family
MCM family
uniprot
proteins
pubmed
11095689
uniprot
proteins
pubmed
11788828
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16899510
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17116885
uniprot
proteins
pubmed
17159977
uniprot
proteins
pubmed
17296731
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20202939
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
22967762
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25661590
uniprot
proteins
pubmed
29290612
uniprot
proteins
pubmed
32453425
uniprot
proteins
pubmed
34694004
uniprot
proteins
pubmed
34700328
uniprot
proteins
pubmed
35585232
uniprot
proteins
pubmed
37198333
uniprot
proteins
pubmed
8977093
uniprot
proteins
pubmed
9286856
uniprot
proteins
pubmed
9305914
uniprot
proteins
pubmed
9516426
uniprot
proteins
sequence_length
821
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16899510}. Chromosome {ECO:0000269|PubMed:16899510}. Note=Binds to chromatin during G1 and detaches from it during S phase. {ECO:0000269|PubMed:16899510}.
uniprot
proteins