Pafah2
entrez
100163
canonical
uniprot
Q8VDG7
canonical
ensembl
ENSMUSG00000037366
resolver
ensp
ENSMUSP00000101495
resolver
ensp
ENSMUSP00000101496
resolver
ensp
ENSMUSP00000207186
resolver
ensp
ENSMUSP00000207189
resolver
enst
ENSMUST00000105869
resolver
enst
ENSMUST00000105870
resolver
genesymbol
Pafah2
resolver
uniprot
E9QNW6
resolver
uniprot
E9QNW7
resolver
uniprot
Q8R0Y7
resolver
uniprot_entry
E9QNW6_MOUSE
resolver
uniprot_entry
PAFA2_MOUSE
resolver
uniprot_sec
E9QNW7
resolver
uniprot_sec
Q8R0Y7
resolver
amino_acid_sequence
MGAGQSVCFPPISGPHHIGCTDVMEGHSLEGSLFRLFYPCQASEKCEQPLWIPRYEYSMGLADYLQYNKRWVGLLFNVGIGSCRLPVSWNGPFKAKESGYPLIILSHGLGGFRASYSAFCMELASRGFVVAAVEHRDQSAAATYFCKPTSQESSPAESLEEEWLPFRRIKEGEKEFHVRNPQVHQRVKECVRVLRILQDASAGKTVVNVFPGGLDLMTLKGSIDRNRVAVMGHSFGGATAVLALTQEVQFRCAIALDAWMFPLERDFYPKARGPVFFINVEKFQTVESVNLMKKICAQHEQSRIVTVLGAVHRSQTDFAFVTGNLIAKFFSSNSRGTLDPYESQEVMVRAILAFLQKHLDLKEDYDQWSSFIEGVGPSLIQGAPHYLSSL
uniprot
proteins
ec_number
2.3.1.149
uniprot
proteins
ec_number
3.1.1.47
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolyze of the acetyl group at the sn-2 position of platelet-activating factor (PAF) and its analogs, leading to their inactivation (By similarity). Hydrolyzes propionyl and butyroyl moieties approximately half as effectively as PAF (By similarity). Also catalyzes transacetylation of the acetyl group from platelet-activating factor (PAF) to lysoplasmalogen and to sphingosine, producing plasmalogen analogs of PAF and N-acetylsphingosine (C2-ceramide) respectively. Has a marked selectivity for phospholipids with short acyl chains at the sn-2 position (By similarity). {ECO:0000250|UniProtKB:P79106, ECO:0000250|UniProtKB:P83006}.
uniprot
proteins
mass_dalton
43562
uniprot
proteins
protein_family
Serine esterase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
390
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P79106}. Membrane {ECO:0000250|UniProtKB:P79106}; Lipid-anchor {ECO:0000250|UniProtKB:P79106}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P79106}; Lipid-anchor {ECO:0000250|UniProtKB:P79106}. Note=In resting cells, localizes to intracellular membranes and cytoplasm. Translocates from the cytoplasm to intracellular membranes upon oxidative stress. {ECO:0000250|UniProtKB:P79106}.
uniprot
proteins