Slurp1
entrez
57277
canonical
uniprot
Q9Z0K7
canonical
ensembl
ENSMUSG00000022596
resolver
ensp
ENSMUSP00000141013
resolver
enst
ENSMUST00000190433
resolver
genesymbol
Slurp1
resolver
genesymbol_syn
Ars
resolver
uniprot
Q2TA55
resolver
uniprot_entry
SLUR1_MOUSE
resolver
uniprot_sec
Q2TA55
resolver
amino_acid_sequence
MTLRWAMWLLLLAAWSMGYGEAFRCYTCEQPTAINSCKNIAQCKMEDTACKTVLETVEAAFPFNHSPMVTRSCSSSCLATDPDGIGVAHPVFCCFRDLCNSGFPGFVAGL
uniprot
proteins
function
FUNCTION: Has an antitumor activity. Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin. In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner (By similarity). In T cells may be involved in regulation of intracellular Ca(2+) signaling (PubMed:17286989). Seems to have a immunomodulatory function in the cornea. The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation (PubMed:23139280, PubMed:25168896). {ECO:0000250|UniProtKB:P55000, ECO:0000269|PubMed:17286989, ECO:0000269|PubMed:23139280, ECO:0000269|PubMed:25168896}.
uniprot
proteins
mass_dalton
12016
uniprot
proteins
pubmed
14721776
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17286989
uniprot
proteins
pubmed
19396877
uniprot
proteins
pubmed
20621062
uniprot
proteins
pubmed
23139280
uniprot
proteins
pubmed
24499735
uniprot
proteins
pubmed
25168896
uniprot
proteins
sequence_length
110
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P55000}.
uniprot
proteins