GPR6
entrez
2830
canonical
uniprot
P46095
canonical
ensembl
ENSG00000146360
resolver
ensp
ENSP00000275169
resolver
ensp
ENSP00000406986
resolver
genesymbol
GPR6
resolver
hgnc
HGNC:4515
resolver
uniprot
B4DHS9
resolver
uniprot
F1DAM6
resolver
uniprot
J3KQR3
resolver
uniprot
Q17RJ7
resolver
uniprot
Q5SYL0
resolver
uniprot_entry
F1DAM6_HUMAN
resolver
uniprot_entry
GPR6_HUMAN
resolver
uniprot_sec
B4DHS9
resolver
uniprot_sec
J3KQR3
resolver
uniprot_sec
Q17RJ7
resolver
uniprot_sec
Q5SYL0
resolver
amino_acid_sequence
MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQLSAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGIMLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPSEV
uniprot
proteins
function
FUNCTION: Constitutively active G protein-coupled receptor that maintains high cAMP levels and contributes to several processes including neuronal development, through activation of intracellular signaling pathways via G(s). May be activated by lipid-derived agonists such as oleic acid or sphingosine 1-phosphate, leading to activation of the G(s)/cAMP/PKA signaling pathway (PubMed:12220620, PubMed:39626010). {ECO:0000269|PubMed:12220620, ECO:0000269|PubMed:39626010}.
uniprot
proteins
mass_dalton
37881
uniprot
proteins
mutagenesis
MUTAGEN 166; /note="R->A: Strong decrease of GPR6-mediated signaling."; /evidence="ECO:0000269|PubMed:39626010
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12220620
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19059244
uniprot
proteins
pubmed
19286662
uniprot
proteins
pubmed
39626010
uniprot
proteins
pubmed
7832990
uniprot
proteins
pubmed
8530049
uniprot
proteins
sequence_length
362
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:19059244}; Multi-pass membrane protein {ECO:0000305|PubMed:19059244}. Note=Detected in the intracellular compartments. It is currently unclear whether this is a cell surface or intracellular receptor.
uniprot
proteins
transmembrane_region
TRANSMEM 75..94; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 107..130; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 143..164; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 186..205; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 231..249; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 278..304; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 310..331; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins