ASB1
entrez
51665
canonical
uniprot
Q9Y576
canonical
ensembl
ENSG00000065802
resolver
ensp
ENSP00000264607
resolver
ensp
ENSP00000387025
resolver
enst
ENST00000264607
resolver
enst
ENST00000409297
resolver
genesymbol
ASB1
resolver
genesymbol_syn
KIAA1146
resolver
hgnc
HGNC:16011
resolver
uniprot
A6NL50
resolver
uniprot
B9A047
resolver
uniprot
Q4ZG29
resolver
uniprot
Q9ULS4
resolver
uniprot_entry
ASB1_HUMAN
resolver
uniprot_entry
B9A047_HUMAN
resolver
uniprot_sec
A6NL50
resolver
uniprot_sec
Q4ZG29
resolver
uniprot_sec
Q9ULS4
resolver
amino_acid_sequence
MAEGGSPDGRAGPGSAGRNLKEWLREQFCDHPLEHCEDTRLHDAAYVGDLQTLRSLLQEESYRSRINEKSVWCCGWLPCTPLRIAATAGHGSCVDFLIRKGAEVDLVDVKGQTALYVAVVNGHLESTQILLEAGADPNGSRHHRSTPVYHASRVGRADILKALIRYGADVDVNHHLTPDVQPRFSRRLTSLVVCPLYISAAYHNLQCFRLLLLAGANPDFNCNGPVNTQGFYRGSPGCVMDAVLRHGCEAAFVSLLVEFGANLNLVKWESLGPESRGRRKVDPEALQVFKEARSVPRTLLCLCRVAVRRALGKHRLHLIPSLPLPDPIKKFLLHE
uniprot
proteins
function
FUNCTION: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:16325183). Mediates Notch-induced ubiquitination and degradation of TCF3/E2A and JAK2 (PubMed:21119685). Functions as a tumor suppressor by enhancing CHCHD3 'Lys-48'-linked ubiquitination, leading to inhibition of the CHCHD3/ROS signaling pathway (PubMed:39113857). Suppresses TAB2-linked 'Lys-48' polyubiquitination and consequently facilitates the initiation of NF-kappa-B and MAPK signaling cascades (PubMed:33431678). May play a role in testis development (By similarity). {ECO:0000250|UniProtKB:Q9WV74, ECO:0000269|PubMed:16325183, ECO:0000269|PubMed:21119685, ECO:0000269|PubMed:33431678, ECO:0000269|PubMed:39113857}.
uniprot
proteins
mass_dalton
37014
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
Ankyrin SOCS box (ASB) family
uniprot
proteins
pubmed
10574461
uniprot
proteins
pubmed
11111040
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16325183
uniprot
proteins
pubmed
21119685
uniprot
proteins
pubmed
33431678
uniprot
proteins
pubmed
39113857
uniprot
proteins
sequence_length
335
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:33431678}.
uniprot
proteins