Slc4a7
entrez
117955
canonical
uniprot
Q9R1N3
canonical
ensembl
ENSRNOG00000005957
resolver
ensp
ENSRNOP00000008759
resolver
ensp
ENSRNOP00000063542
resolver
ensp
ENSRNOP00000097556
resolver
genesymbol
Slc4a7
resolver
genesymbol_syn
Nbc
resolver
genesymbol_syn
Nbc2
resolver
genesymbol_syn
Nbc3
resolver
genesymbol_syn
Nbcn1
resolver
genesymbol_syn
slc4a7
resolver
uniprot
A0A0K0WYI6
resolver
uniprot
F1M0J3
resolver
uniprot
Q9QYD5
resolver
uniprot
Q9R1L1
resolver
uniprot_entry
A0A0K0WYI6_RAT
resolver
uniprot_entry
F1M0J3_RAT
resolver
uniprot_entry
S4A7_RAT
resolver
uniprot_sec
Q9QYD5
resolver
uniprot_sec
Q9R1L1
resolver
activity_regulation
ACTIVITY REGULATION: Insensitive to stilbene derivatives. {ECO:0000269|PubMed:14673192, ECO:0000269|PubMed:15075186}.
uniprot
proteins
amino_acid_sequence
MEADGAGEQMRPLLTRGPDEEAVVDLGKTSSTVNTKFEKEELESHRAVYVGVHVPFSKESRRRHRHRGHKHHHRRRKDKDSDKEDGRESPSYDTPSQRVQFILGTEDDDEEHIPHDLFTEMDELCYRDGEEYEWKETARWLKFEEDVEDGGDRWSKPYVATLSLHSLFELRSCILNGTVMLDMRASTLDEIADMVLDNMIASGQLDDSIRENVREALLKRHHHQNEKRFTSRIPLVRSFADIGKKHSDPHLLERNGEGLSASRHSLRTGLSASNLSLRGESPLSLLLSHLLPSSRAGTPAGSRCTTPVPTPQNSPPSSPSLSRLTSRSSQQTQPQAPEVLVSPDRDDIPRVVIHPPEEDIEALKGQEQKNEENTDFTPGILASPQSAPGNLDSSKSGEVKGNGSGGSRENSTVDFSKVDMNFMRKIPTGAEASNVLVGEVDFLERPIIAFVRLAPAVLLSGLTEVPVPTRFLFLLLGPAGKAPQYHEIGRSIATLMTDEIFHDVAYKAKDRNDLLSGIDEFLDQVTVLPPGEWDPSIRIEPPKSVPSQEKRKIPAFPNGSAPVSADPPKEADHHAGPELQRTGRLFGGLILDIKRKAPFFLSDFKDALSLQCLASILFLYCACMSPVITFGGLLGEATEGRISAIESLFGASLTGIAYSLFAGQPLTILGSTGPVLVFEKILFKFCRDYHLSYLSLRTSIGLWTSFLCIVLVATDASSLVCYITRFTEEAFAALICIIFIYEALEKLFHLGEIYAFNMHNNLDALTSYTCVCAEPSNPSNETVELWERKNVTAASISWANLTVSECKTFHGMFVGSACGPHGPYVPDVLFWCVVLFFTTFFLSSFLKQFKTKRYFPTKVRSTISDFAVFLTIVIMVAIDYLVGIPSPKLHVPEKFEPTDPSRGWIISPLGDNPWWTLLIAAVPALLCTILIFMDQQITAVIINRKEHKLKKGAGYHLDLLMVAVMLGVCSIMGLPWFVAATVLSISHVNSLKVESECSAPGEQPKFLGIREQRVTGLMIFILMGLSVFMTSVLKFIPMPVLYGVFLYMGVSSLKGIQFFDRIKLFGMPAKHQPDLIYLRYVPLWKVHVFTVVQLTCLVLLWVIKASAAAVVFPMMVLALVFVRKLMDLCFTKRELSWLDDLMPESKKKKEDDKKKKEKEEAERMLQGDGDTVHLPFERGSLLQIPVKTLKYSPEKPVSVTINFEDEPSKKYMDAETSL
uniprot
proteins
function
FUNCTION: Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry (PubMed:10850716, PubMed:14673192, PubMed:15075186). Mediates the sodium-dependent bicarbonate transport important for pH recovery after acid load as well as for regulation of steady-state pH in the duodenum and vascular smooth muscle cells (By similarity). Plays a key role in macrophage acidification, mediating bicarbonate import into the cytoplasm which is crucial for net acid extrusion and maintenance of cytoplasmic pH during phagocytosis (By similarity). Provides cellular bicarbonate for de novo purine and pyrimidine synthesis and is a key mediator of de novo nucleotide synthesis downstream of mTORC1 signaling in proliferating cells (By similarity). {ECO:0000250|UniProtKB:Q8BTY2, ECO:0000250|UniProtKB:Q9Y6M7, ECO:0000269|PubMed:10850716, ECO:0000269|PubMed:14673192, ECO:0000269|PubMed:15075186}.
uniprot
proteins
mass_dalton
135954
uniprot
proteins
post_translational_modification
PTM: [Isoform 2]: Undergoes lysosome-mediated degradation. {ECO:0000269|PubMed:29743600}.; PTM: N-glycosylated. {ECO:0000269|PubMed:11053051}.
uniprot
proteins
protein_family
Anion exchanger (TC 2.A.31) family
uniprot
proteins
pubmed
10662737
uniprot
proteins
pubmed
10850716
uniprot
proteins
pubmed
10975418
uniprot
proteins
pubmed
11053051
uniprot
proteins
pubmed
12403779
uniprot
proteins
pubmed
14673192
uniprot
proteins
pubmed
15075186
uniprot
proteins
pubmed
15718246
uniprot
proteins
pubmed
16126812
uniprot
proteins
pubmed
16301216
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
29743600
uniprot
proteins
sequence_length
1218
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:10662737, ECO:0000269|PubMed:11053051, ECO:0000269|PubMed:14673192, ECO:0000269|PubMed:15075186, ECO:0000269|PubMed:16126812}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:10662737, ECO:0000269|PubMed:10975418}; Multi-pass membrane protein {ECO:0000255}. Cell projection, stereocilium {ECO:0000269|PubMed:16301216}. Note=Localizes to the stereocilia of cochlear outer hair cells and to the lateral membrane of cochlear inner hair cells. {ECO:0000269|PubMed:16301216}.; SUBCELLULAR LOCATION: [Isoform 2]: Basolateral cell membrane {ECO:0000269|PubMed:29743600}; Multi-pass membrane protein {ECO:0000255}. Note=RACK1 is important for its membrane localization. {ECO:0000269|PubMed:29743600}.; SUBCELLULAR LOCATION: [Isoform 6]: Cell membrane {ECO:0000269|PubMed:15718246}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 613..633; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 642..662; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 700..720; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 730..750; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 822..842; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 866..886; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 913..933; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 959..979; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1016..1036; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1039..1059; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1097..1117; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins