Tmc6
entrez
217353
canonical
uniprot
Q7TN60
canonical
ensembl
ENSMUSG00000025572
resolver
ensp
ENSMUSP00000026659
resolver
ensp
ENSMUSP00000256110
resolver
ensp
ENSMUSP00000256112
resolver
ensp
ENSMUSP00000256121
resolver
ensp
ENSMUSP00000256123
resolver
ensp
ENSMUSP00000256133
resolver
ensp
ENSMUSP00000256136
resolver
ensp
ENSMUSP00000338955
resolver
ensp
ENSMUSP00000338957
resolver
enst
ENSMUST00000026659
resolver
genesymbol
Tmc6
resolver
genesymbol_syn
Ever1
resolver
uniprot
B1ATB3
resolver
uniprot
B1ATB4
resolver
uniprot
Q78JR7
resolver
uniprot
Q7TQ68
resolver
uniprot
Q8BP52
resolver
uniprot
Q8C6Z5
resolver
uniprot
Q99J32
resolver
uniprot_entry
B1ATB3_MOUSE
resolver
uniprot_entry
TMC6_MOUSE
resolver
uniprot_sec
B1ATB4
resolver
uniprot_sec
Q78JR7
resolver
uniprot_sec
Q7TQ68
resolver
uniprot_sec
Q8BP52
resolver
uniprot_sec
Q8C6Z5
resolver
uniprot_sec
Q99J32
resolver
amino_acid_sequence
MAQSLALALDVPETTGDEGLEPSPYEESEVHDSFHQLIQEQSLRVAEEGLELLPLGLGRGDQTLPGLEGAPALSSATLRILASMPSRTIGRSRGAIISQYYNRTVRLRRRSSRPLLGNVVPSARPSLRLYDLELDSTILEEDEKRSLLVKELQGLSAAQRDHMVRNMPLSLGEKRCLREKSWSPKGKRRHLQGRSGAFSCCSRLRYTCMLALHSLGLALLSGLYAARPWRYALKQIGGQFGSSVLSYFLFLKTLLAFNALMLLPLLAFLVGVQAAFPPDPAGPVPTFSGLELLTGGGRFTHTVMYYGYYSNSTLSPSCDAPREGGQCSPRLGSLPYNMPLAYLFTMGATFFLTCIILVYSMSHSFGESYRVGSTKGIHALTVFCSWDYKVTQKRASRVQQDSICTQLKELLAEWHLRKRPRSVCGQLRQVVVLGLGWLLCLGSTMGCTVAVLTFSEVMIQRPASGGQGVEALALPLVVSVLNLGASYLFRGLATLERHDSPVLEVYMAICRNLILKMAVLGVLCYHWLGRRVATLQGQCWEDFVGQELYRFMVVDFIFMLLDSLFGELVWRLISEKKLKRGQKPEFDIARNVLDLIYGQTLTWLGVLFSPLLPAVQILRLLFLFHIKKASLMANCQAPRRPWLASHMSTVFLTLLCFPSFLGAAVFLCYAVWQVRPSSTCGPFRTLNTMYEAGTVWVRRLEHAGSGASWLPWLHHFLVENTFFLFLASALLLAVIYFNIQVVKGQRKVICLLKEQIRNEGEDKIFLINKLHSVYEEEGRSRPGRTQDATEPPAWHEDGGDQKEPCNPRSP
uniprot
proteins
function
FUNCTION: Acts as a regulatory protein involved in the regulation of numerous cellular processes (PubMed:32917726, PubMed:38440182). Together with its homolog TMC8/EVER2, forms a complex with calcium-binding protein CIB1 in lymphocytes and keratynocytes where TMC6 and TMC8 stabilize CIB1 and reciprocally (PubMed:32917726). Together with TMC8, also forms a complex with and activates zinc transporter ZNT1 at the ER membrane of keratynocytes, thereby facilitating zinc uptake into the ER (By similarity). Down-regulates the activity of transcription factors induced by zinc and cytokines (By similarity). Also plays a role in thermal sensation by inhibiting the M-channel (KCNQ2-KCNQ3 channel) current in primary sensory neurons (PubMed:38440182). {ECO:0000250|UniProtKB:Q7Z403, ECO:0000269|PubMed:32917726, ECO:0000269|PubMed:38440182}.
uniprot
proteins
mass_dalton
90546
uniprot
proteins
protein_family
TMC family
uniprot
proteins
pubmed
12812529
uniprot
proteins
pubmed
12906855
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
32917726
uniprot
proteins
pubmed
38440182
uniprot
proteins
sequence_length
810
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 206..226; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 254..274; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 339..359; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 430..450; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 469..489; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 505..525; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 553..573; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 604..624; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 650..670; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 722..742; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins