CKAP2L
entrez
150468
canonical
uniprot
Q8IYA6
canonical
ensembl
ENSG00000169607
resolver
ensp
ENSP00000305204
resolver
genesymbol
CKAP2L
resolver
hgnc
HGNC:26877
resolver
uniprot
A8K915
resolver
uniprot
B4DZE3
resolver
uniprot
B7ZAC6
resolver
uniprot
F5H0M5
resolver
uniprot
Q53QF8
resolver
uniprot
Q53RS8
resolver
uniprot
Q8N1J8
resolver
uniprot_entry
CKP2L_HUMAN
resolver
uniprot_sec
A8K915
resolver
uniprot_sec
B4DZE3
resolver
uniprot_sec
B7ZAC6
resolver
uniprot_sec
F5H0M5
resolver
uniprot_sec
Q53QF8
resolver
uniprot_sec
Q53RS8
resolver
uniprot_sec
Q8N1J8
resolver
amino_acid_sequence
MVGPGPTAAAAVEERQRKLQEYLAAKGKLKSQNTKPYLKSKNNCQNQPPSKSTIRPKNDVTNHVVLPVKPKRSISIKLQPRPPNTAGSQKPKLEPPKLLGKRLTSECVSSNPYSKPSSKSFQQCEAGSSTTGELSRKPVGSLNIEQLKTTKQQLTDQGNGKCIDFMNNIHVENESLDNFLKETNKENLLDILTEPERKPDPKLYTRSKPKTDSYNQTKNSLVPKQALGKSSVNSAVLKDRVNKQFVGETQSRTFPVKSQQLSRGADLARPGVKPSRTVPSHFIRTLSKVQSSKKPVVKNIKDIKVNRSQYERPNETKIRSYPVTEQRVKHTKPRTYPSLLQGEYNNRHPNIKQDQKSSQVCIPQTSCVLQKSKAISQRPNLTVGRFNSAIPSTPSIRPNGTSGNKHNNNGFQQKAQTLDSKLKKAVPQNHFLNKTAPKTQADVTTVNGTQTNPNIKKKATAEDRRKQLEEWQKSKGKTYKRPPMELKTKRKVIKEMNISFWKSIEKEEEEKKAQLELSSKINNTLTECLNLIEGGVPSNEILNILSSIPEAEKFAKFWICKAKLLASKGTFDVIGLYEEAIKNGATPIQELRKVVLNILQDSNRTTEGITSDSLVAETSITSVEELAKKMESVKSCLSPKEREQVTATPRIAKAEQHNYPGIKLQIGPIPRINGMPEVQDMKFITPVRRSSRIERAVSRYPEMLQEHDLVVASLDELLEVEETKCFIFRRNEALPVTLGFQTPES
uniprot
proteins
disease_involvement
DISEASE: Filippi syndrome (FLPIS) [MIM:272440]: A rare disorder characterized by microcephaly, pre- and postnatal growth failure, syndactyly, and distinctive facial features, including a broad nasal bridge and underdeveloped alae nasi. Some affected individuals have intellectual disability, seizures, undescended testicles in males, and teeth and hair abnormalities. {ECO:0000269|PubMed:25439729}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells. {ECO:0000269|PubMed:25439729}.
uniprot
proteins
mass_dalton
83587
uniprot
proteins
mutagenesis
MUTAGEN 198; /note="K->R: Abrogates sumoylation."; /evidence="ECO:0000269|PubMed:20388717
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C). {ECO:0000250}.
uniprot
proteins
protein_family
CKAP2 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20388717
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25439729
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
745
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:25439729}. Note=Uniformly distributed along each microtubule bundle of spindles in addition to centrioles during mitosis, expression promptly diminishes at interphase. {ECO:0000269|PubMed:25439729}.
uniprot
proteins