Atg9a
entrez
245860
canonical
uniprot
Q68FE2
canonical
ensembl
ENSMUSG00000033124
resolver
ensp
ENSMUSP00000047449
resolver
ensp
ENSMUSP00000139641
resolver
ensp
ENSMUSP00000139731
resolver
ensp
ENSMUSP00000275437
resolver
ensp
ENSMUSP00000275455
resolver
genesymbol
Atg9a
resolver
genesymbol_syn
Apg9l1
resolver
uniprot
Q3ZAQ4
resolver
uniprot_entry
ATG9A_MOUSE
resolver
uniprot_sec
Q3ZAQ4
resolver
amino_acid_sequence
MAQFDTEYQRLEASYSDSPPGEEDLLVHVAEGSKSPWHHIENLDLFFSRVYNLHQKNGFTCMLIGEMFELMQFLFVVAFTTFLVSCVDYDILFANKMVNHSLHPTEPVKVTLPDAFLPAQVCSARIQENGSLITILVIAGVFWIHRLIKFIYNICCYWEIHSFYLHALRIPMSALPYCTWQEVQARIVQTQKEHQICIHKRELTELDIYHRILRFQNYMVALVNKSLLPLRFRLPGLGEVVFFTRGLKYNFELILFWGPGSLFLNEWSLKAEYKRGGQRLELAQRLSNRILWIGIANFLLCPLILIWQILYAFFSYAEVLKREPGALGARCWSLYGRCYLRHFNELEHELQSRLNRGYKPASKYMNCFLSPLLTLLAKNGAFFAGSILAVLIALTIYDEDVLAVEHVLTTVTLLGVTVTVCRSFIPDQHMVFCPEQLLRVILAHIHYMPDHWQGNAHRSQTRDEFAQLFQYKAVFILEELLSPIVTPLILIFCLRPRALEIIDFFRNFTVEVVGVGDTCSFAQMDVRQHGHPQWLSGGQTEASVYQQAEDGKTELSLMHFAITNPGWQPPRESTAFLGFLKEQVQRDGAAAGLAQGGLLPENALFTSIQSLQSESEPLSLIANVVAGSSCRGPSLSRDLQGSRHRADVASALRSFSPLQPGAAPQGRVPSTMTGSGVDARTASSGSSVWEGQLQSLVLSEYASTEMSLHALYMHQLHKQQTQAEPERHVWHRRESDESGESAPEEGGEGARAPQPIPRSASYPCATPRPGAPETTALHGGFQRRYGGITDPGTVPRGPSHFSRLPLGGWAEDGQPASRHPEPVPEEGSEDELPPQVHKV
uniprot
proteins
function
FUNCTION: Phospholipid scramblase involved in autophagy by mediating autophagosomal membrane expansion (PubMed:23402761, PubMed:27587839). Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome (By similarity). Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 (ATG2A or ATG2B) from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion (By similarity). Also required to supply phosphatidylinositol 4-phosphate to the autophagosome initiation site by recruiting the phosphatidylinositol 4-kinase beta (PI4KB) in a process dependent on ARFIP2, but not ARFIP1 (By similarity). In addition to autophagy, also plays a role in necrotic cell death (PubMed:27811852). {ECO:0000250|UniProtKB:Q7Z3C6, ECO:0000269|PubMed:23402761, ECO:0000269|PubMed:27587839, ECO:0000269|PubMed:27811852}.
uniprot
proteins
mass_dalton
94425
uniprot
proteins
mutagenesis
MUTAGEN 8..11; /note="YQRL->AAAA: Decreased localization to the Golgi apparatus; when associated with 22-A--A-27."; /evidence="ECO:0000269|PubMed:27587839"; MUTAGEN 22..27; /note="EEDLLV->AAAAA: Decreased localization to the Golgi apparatus; when associated with 8-A--A-11."; /evidence="ECO:0000269|PubMed:27587839
uniprot
proteins
post_translational_modification
PTM: Ufmylated in a DDRGK1 dependent manner. {ECO:0000269|PubMed:37086384}.
uniprot
proteins
protein_family
ATG9 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15755735
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19926846
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23402761
uniprot
proteins
pubmed
26370455
uniprot
proteins
pubmed
27587839
uniprot
proteins
pubmed
27811852
uniprot
proteins
pubmed
28513333
uniprot
proteins
pubmed
37086384
uniprot
proteins
sequence_length
839
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Preautophagosomal structure membrane {ECO:0000250|UniProtKB:Q7Z3C6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7Z3C6}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:15755735}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7Z3C6}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:27587839}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7Z3C6}. Late endosome membrane {ECO:0000250|UniProtKB:Q7Z3C6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7Z3C6}. Recycling endosome membrane {ECO:0000269|PubMed:27587839}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7Z3C6}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q7Z3C6}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q7Z3C6}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q7Z3C6}; Multi-pass membrane protein {ECO:0000255}. Note=Mainly localizes to the trans-Golgi network (TGN) and the endosomal system; cycles between them though vesicle trafficking (PubMed:27587839). Export from the TGN to promote formation of autophagosomes is mediated by the AP-4 complex. Under amino acid starvation or rapamycin treatment, redistributes to preautophagosomal structure/phagophore assembly site (PAS). The starvation-induced redistribution depends on ULK1, ATG13, as well as SH3GLB1. Upon autophagy induction, a portion of transiently localizes to the autophagic membranes (By similarity). Recruited to damaged mitochondria during mitophagy in a RIMOC1-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q7Z3C6, ECO:0000269|PubMed:27587839}.
uniprot
proteins
transmembrane_region
TRANSMEM 62..84; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q7Z3C6"; TRANSMEM 129..154; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q7Z3C6"; TRANSMEM 372..397; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q7Z3C6"; TRANSMEM 407..424; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q7Z3C6
uniprot
proteins