NECAB3
entrez
63941
canonical
uniprot
Q96P71
canonical
ensembl
ENSG00000125967
resolver
ensp
ENSP00000246190
resolver
ensp
ENSP00000364386
resolver
ensp
ENSP00000475369
resolver
ensp
ENSP00000553804
resolver
genesymbol
NECAB3
resolver
genesymbol_syn
APBA2BP
resolver
genesymbol_syn
NIP1
resolver
genesymbol_syn
SYTIP2
resolver
genesymbol_syn
XB51
resolver
hgnc
HGNC:15851
resolver
uniprot
A8K780
resolver
uniprot
E1P5N2
resolver
uniprot
Q5JWF5
resolver
uniprot
Q5JWF6
resolver
uniprot
Q5JWF7
resolver
uniprot
Q86VV1
resolver
uniprot
Q9H433
resolver
uniprot
Q9H8G8
resolver
uniprot
Q9HBW7
resolver
uniprot
Q9HCQ9
resolver
uniprot_entry
NECA3_HUMAN
resolver
uniprot_sec
A8K780
resolver
uniprot_sec
E1P5N2
resolver
uniprot_sec
Q5JWF5
resolver
uniprot_sec
Q5JWF6
resolver
uniprot_sec
Q5JWF7
resolver
uniprot_sec
Q86VV1
resolver
uniprot_sec
Q9H433
resolver
uniprot_sec
Q9H8G8
resolver
uniprot_sec
Q9HBW7
resolver
uniprot_sec
Q9HCQ9
resolver
amino_acid_sequence
MACAGLLTVCLLRPPAPQPQPQTPRHPQLAPDPGPAGHTLFQDVFRRADKNDDGKLSFEEFQNYFADGVLSLGELQELFSGIDGHLTDNLETEKLCDYFSEHLGVYRPVLAALESLNRAVLAAMDATKLEYERASKVDQFVTRFLLRETVSQLQALQSSLEGASDTLEAQAHGWRSDAESVEAQSRLCGSRRAGRRALRSVSRSSTWSPGSSDTGRSSEAEMQWRLQVNRLQELIDQLECKVRAVGPGPHKGGPSWYPPEPGPCWRPGPHSVPSQAPRLEPLREEDLAKGPDLHILMAQRQVQVAEEGLQDFHRALRCYVDFTGAQSHCLHVSAQKMLDGASFTLYEFWQDEASWRRHQQSPGSKAFQRILIDHLRAPDTLTTVFFPASWWIMNNN
uniprot
proteins
function
FUNCTION: Inhibits the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid-beta. May enhance the activity of HIF1A and thus promote glycolysis under normoxic conditions; the function requires its ABM domain and may implicate the stabilization of the interaction between HIF1AN and APBA3. {ECO:0000269|PubMed:10833507, ECO:0000269|PubMed:26948053}.
uniprot
proteins
mass_dalton
44350
uniprot
proteins
mutagenesis
MUTAGEN 358; /note="H->A: No effect on interaction with APBA3."; /evidence="ECO:0000269|PubMed:26948053
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by NEK2. {ECO:0000305|PubMed:14697346}.
uniprot
proteins
pubmed
10833507
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12044471
uniprot
proteins
pubmed
14697346
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
26948053
uniprot
proteins
sequence_length
396
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:10833507, ECO:0000269|PubMed:14697346, ECO:0000269|PubMed:26948053}.
uniprot
proteins