Agtr1
entrez
24180
canonical
uniprot
P25095
canonical
ensembl
ENSRNOG00000018346
resolver
ensembl
ENSRNOG00055013980
resolver
ensembl
ENSRNOG00060019076
resolver
ensembl
ENSRNOG00065023214
resolver
ensp
ENSRNOP00000034687
resolver
ensp
ENSRNOP00000091615
resolver
ensp
ENSRNOP00055019609
resolver
ensp
ENSRNOP00055019617
resolver
ensp
ENSRNOP00060026955
resolver
ensp
ENSRNOP00060027003
resolver
ensp
ENSRNOP00065032228
resolver
ensp
ENSRNOP00065032252
resolver
enst
ENSRNOT00000038532
resolver
enst
ENSRNOT00000102465
resolver
enst
ENSRNOT00055024035
resolver
enst
ENSRNOT00055024048
resolver
enst
ENSRNOT00060032958
resolver
enst
ENSRNOT00060033009
resolver
enst
ENSRNOT00065039637
resolver
enst
ENSRNOT00065039660
resolver
genesymbol
Agtr1
resolver
genesymbol_syn
Agtr1a
resolver
genesymbol_syn
At1a
resolver
uniprot
Q9QVS5
resolver
uniprot_entry
AGTRA_RAT
resolver
uniprot_sec
Q9QVS5
resolver
amino_acid_sequence
MALNSSAEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYFIENTNITVCAFHYESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCKISDIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKMSTLSYRPSDNMSSSAKKPASCFEVE
uniprot
proteins
function
FUNCTION: Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney (PubMed:10747880, PubMed:2041570). The activated receptor in turn couples to G-alpha proteins G(q) (GNAQ, GNA11, GNA14 or GNA15) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C (PubMed:10747880). {ECO:0000269|PubMed:10747880, ECO:0000269|PubMed:2041570}.
uniprot
proteins
mass_dalton
40890
uniprot
proteins
mutagenesis
MUTAGEN 238; /note="I->A,S,K: Decreased angiotensin II-induced inositol phosphate response."; /evidence="ECO:0000269|PubMed:10747880"; MUTAGEN 238; /note="I->D: Abolished angiotensin II-induced inositol phosphate response."; /evidence="ECO:0000269|PubMed:10747880"; MUTAGEN 239; /note="F->D: Reduced angiotensin II-induced inositol phosphate response."; /evidence="ECO:0000269|PubMed:10747880"; MUTAGEN 239; /note="F->R,K: Increased angiotensin II-induced inositol phosphate response."; /evidence="ECO:0000269|PubMed:10747880
uniprot
proteins
post_translational_modification
PTM: C-terminal Ser or Thr residues may be phosphorylated. {ECO:0000250|UniProtKB:P30556}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10747880
uniprot
proteins
pubmed
11579203
uniprot
proteins
pubmed
1533121
uniprot
proteins
pubmed
1544458
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1599457
uniprot
proteins
pubmed
2041570
uniprot
proteins
pubmed
2043116
uniprot
proteins
pubmed
7713098
uniprot
proteins
sequence_length
359
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P30556}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P30556}.
uniprot
proteins
transmembrane_region
TRANSMEM 26..55; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P30556"; TRANSMEM 62..89; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P30556"; TRANSMEM 99..125; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P30556"; TRANSMEM 142..165; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P30556"; TRANSMEM 191..216; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P30556"; TRANSMEM 240..268; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P30556"; TRANSMEM 279..304; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P30556
uniprot
proteins