Cd93
entrez
84398
canonical
uniprot
Q9ET61
canonical
ensembl
ENSRNOG00000024799
resolver
ensembl
ENSRNOG00055025333
resolver
ensembl
ENSRNOG00060001976
resolver
ensembl
ENSRNOG00065024335
resolver
ensp
ENSRNOP00000089608
resolver
ensp
ENSRNOP00055035675
resolver
ensp
ENSRNOP00060002071
resolver
ensp
ENSRNOP00065034109
resolver
enst
ENSRNOT00000076493
resolver
enst
ENSRNOT00055043685
resolver
enst
ENSRNOT00060003086
resolver
enst
ENSRNOT00065041732
resolver
genesymbol
Cd93
resolver
genesymbol_syn
C1qr1
resolver
genesymbol_syn
C1qrp
resolver
uniprot
Q9JIZ6
resolver
uniprot_entry
C1QR1_RAT
resolver
uniprot_sec
Q9JIZ6
resolver
amino_acid_sequence
MVTSTGLLLLLGLLGQLWAGAAADSEAVVCEGTACYTAHWGKLSAAEAQHRCNENGGNLATVKSEEEARHVQEALAQLLKTKAPSETKIGKFWIGLQREKGKCTYHDLPMKGFSWVGGGEDTTYSNWYKASKSSCISKRCVSLILDLSLKPHPSHLPKWHESPCGTPDAPGNSIEGFLCKFNFKGMCSPLALGGPGQLTYTTPFQATTSSLKAVPFASVANVVCGDEAESKTNYYLCKETTAGVFHWGSSGPLCVSPKFGCSFNNGGCQQDCFEGGDGSFRCGCRPGFRLLDDLVTCASRNPCSSNPCTGGGMCHSVPLSENYTCHCPRGYQLDSSQVHCVDIDECEDSPCDQECINTPGGFHCECWVGYQSSGSKEEACEDVDECTAAYSPCAQGCTNTDGSFYCSCKEGYIMSGEDSTQCEDIDECLGNPCDTLCINTDGSFRCGCPAGFELAPNGVSCTRGSMFSELPARPPQKEDKGDGKESTVPLTEMPGSLNGSKDVSNRAQTTDLSIQSDSSTASVPLEIEVSSEASDVWLDLGTYLPTTSGHSQPTHEDSVPAHSDSDTDGQKLLLFYILGTVVAISLLLALALGLLIYLKRKAKKEEIKEKKAQNAADSYSWIPERAESRAPENQYSPTPGTDC
uniprot
proteins
function
FUNCTION: Cell surface receptor that plays a role in various physiological processes including inflammation, phagocytosis, and cell adhesion. Plays a role in phagocytosis and enhances the uptake of apoptotic cells and immune complexes by acting as a receptor for defense collagens including surfactant protein A/SFTPA1, C1q, and mannose-binding lectin (MBL2). Plays a role in the regulation of endothelial cell function and adhesion by activating angiogenesis. Mechanistically, exerts its angiogenic function by associating with beta-dystroglycan, leading to SRC-dependent phosphorylation and subsequent recruitment of CBL. In turn, CBL provides a docking site for downstream signaling components, such as CRKL to enhance cell migration. Participates in angiogenesis also by acting as a receptor for the ECM pan-endothelial glycoprotein multimerin-2/MMRN2 and IGFBP7 ligands. Both ligands play a non-redundant role in CD93-mediated endothelial cell function (By similarity). Acts as a key regulator of endothelial barrier function through modulating VEGFR2 function (By similarity). {ECO:0000250|UniProtKB:O89103, ECO:0000250|UniProtKB:Q9NPY3}.
uniprot
proteins
mass_dalton
68782
uniprot
proteins
post_translational_modification
PTM: N- and O-glycosylated. {ECO:0000250|UniProtKB:Q9NPY3}.; PTM: Phosphorylated on Tyr-619 and Tyr-635 by SRC; these phosphorylations promote endothelial cell adhesion and migration. {ECO:0000250|UniProtKB:Q9NPY3}.
uniprot
proteins
pubmed
10934210
uniprot
proteins
pubmed
11093152
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
643
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9NPY3}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9NPY3}.
uniprot
proteins
transmembrane_region
TRANSMEM 572..592; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins