H1-1
entrez
291145
canonical
uniprot
D4A3K5
canonical
ensembl
ENSRNOG00065022951
resolver
ensp
ENSRNOP00065031852
resolver
enst
ENSRNOT00065039211
resolver
genesymbol
H1-1
resolver
genesymbol_syn
Hist1h1a
resolver
uniprot_entry
H11_RAT
resolver
amino_acid_sequence
MSETAPVPQPASVAPEKPAATKKTRKPAKAAVPRKKPAGPSVSELIVQAVSSSKERSGVSLAALKKSLAAAGYDVEKNNSRIKLGLKSLVNKGTLVQTKGTGAAGSFKLNKKAESKASTTKVTVKAKASGAAKKPKKTAGAAAKKTVKTPKKPKKPAVSKKTSSKSPKKPKVVKAKKVAKSPAKAKAVKPKAAKVKVTKPKTPAKPKKAAPKKK
uniprot
proteins
function
FUNCTION: Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex. Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. {ECO:0000250|UniProtKB:P10412}.
uniprot
proteins
mass_dalton
22004
uniprot
proteins
post_translational_modification
PTM: Deamidation of Asn-78 and Asn-79 by CTPS1 in response to DNA damage promotes subsequent acetylation of histone H1 at Lys-77 (H1K75ac). {ECO:0000250|UniProtKB:P10412}.; PTM: Acetylated at Lys-77 (H1K75ac) by EP300 following deamidation of Asn-78 and Asn-79 by CTPS1 in response to DNA damage, thereby increasing chromatin accessibility to facilitate the recruitment of DNA repair proteins. {ECO:0000250|UniProtKB:P10412}.; PTM: H1 histones are progressively phosphorylated during the cell cycle, becoming maximally phosphorylated during late G2 phase and M phase, and being dephosphorylated sharply thereafter. {ECO:0000250|UniProtKB:P43275}.; PTM: Citrullination at Arg-56 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. {ECO:0000250|UniProtKB:P43275}.
uniprot
proteins
protein_family
Histone H1/H5 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
214
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00837}. Chromosome {ECO:0000255|PROSITE-ProRule:PRU00837}. Note=Mainly localizes in euchromatin. {ECO:0000250}.
uniprot
proteins