BHMT
entrez
635
canonical
uniprot
Q93088
canonical
ensembl
ENSG00000145692
resolver
ensp
ENSP00000274353
resolver
enst
ENST00000274353
resolver
genesymbol
BHMT
resolver
genesymbol
HEL-S-61p
resolver
genesymbol_syn
BHMT
resolver
hgnc
HGNC:1047
resolver
uniprot
Q9UNI9
resolver
uniprot
V9HWA4
resolver
uniprot_entry
BHMT1_HUMAN
resolver
uniprot_entry
V9HWA4_HUMAN
resolver
uniprot_sec
Q9UNI9
resolver
amino_acid_sequence
MPPVGGKKAKKGILERLNAGEIVIGDGGFVFALEKRGYVKAGPWTPEAAVEHPEAVRQLHREFLRAGSNVMQTFTFYASEDKLENRGNYVLEKISGQEVNEAACDIARQVADEGDALVAGGVSQTPSYLSCKSETEVKKVFLQQLEVFMKKNVDFLIAEYFEHVEEAVWAVETLIASGKPVAATMCIGPEGDLHGVPPGECAVRLVKAGASIIGVNCHFDPTISLKTVKLMKEGLEAARLKAHLMSQPLAYHTPDCNKQGFIDLPEFPFGLEPRVATRWDIQKYAREAYNLGVRYIGGCCGFEPYHIRAIAEELAPERGFLPPASEKHGSWGSGLDMHTKPWVRARARKEYWENLRIASGRPYNPSMSKPDGWGVTKGTAELMQQKEATTEQQLKELFEKQKFKSQ
uniprot
proteins
ec_number
2.1.1.5
uniprot
proteins
function
FUNCTION: Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline. {ECO:0000269|PubMed:10529246, ECO:0000269|PubMed:8798461, ECO:0000269|PubMed:9681996}.
uniprot
proteins
mass_dalton
44998
uniprot
proteins
mutagenesis
MUTAGEN 216; /note="N->A,C: Decreases the catalytic efficiency."; /evidence="ECO:0000269|PubMed:10529246"; MUTAGEN 217; /note="C->A,S,H: Impairs zinc ion binding. Loss of catalytic activity."; /evidence="ECO:0000269|PubMed:10529246"; MUTAGEN 220; /note="D->A: Has no significant effect on catalytic activity."; MUTAGEN 299; /note="C->A,S: Impairs zinc ion binding. Loss of catalytic activity."; /evidence="ECO:0000269|PubMed:10529246"; MUTAGEN 300; /note="C->A,S: Impairs zinc ion binding. Loss of catalytic activity."; /evidence="ECO:0000269|PubMed:10529246"; MUTAGEN 303; /note="E->A: Has no significant effect on catalytic activity."; /evidence="ECO:0000269|PubMed:10529246"; MUTAGEN 306; /note="H->A: Has no significant effect on catalytic activity."; /evidence="ECO:0000269|PubMed:10529246
uniprot
proteins
pathway_participation
PATHWAY: Amine and polyamine degradation; betaine degradation; sarcosine from betaine: step 1/2.; PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1. {ECO:0000269|PubMed:10529246}.
uniprot
proteins
pubmed
10075673
uniprot
proteins
pubmed
10529246
uniprot
proteins
pubmed
12220488
uniprot
proteins
pubmed
12818402
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8798461
uniprot
proteins
pubmed
9281325
uniprot
proteins
pubmed
9681996
uniprot
proteins
sequence_length
406
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O09171}. Nucleus {ECO:0000250|UniProtKB:O09171}. Note=Predominantly localized in the cytoplasm with a small fraction detected in the nucleus. Translocates into the nucleus upon oxidative stress. {ECO:0000250|UniProtKB:O09171}.
uniprot
proteins