Pttg1
entrez
30939
canonical
uniprot
Q9CQJ7
canonical
ensembl
ENSMUSG00000020415
resolver
ensp
ENSMUSP00000020685
resolver
ensp
ENSMUSP00000020687
resolver
ensp
ENSMUSP00000098894
resolver
ensp
ENSMUSP00000112834
resolver
ensp
ENSMUSP00000112841
resolver
ensp
ENSMUSP00000291477
resolver
ensp
ENSMUSP00000325931
resolver
ensp
ENSMUSP00000351308
resolver
ensp
ENSMUSP00000351311
resolver
ensp
ENSMUSP00000351312
resolver
ensp
ENSMUSP00000364306
resolver
genesymbol
Pttg1
resolver
genesymbol_syn
Pttg
resolver
uniprot
O88887
resolver
uniprot
Q9Z2E6
resolver
uniprot_entry
PTTG1_MOUSE
resolver
uniprot_sec
O88887
resolver
uniprot_sec
Q9Z2E6
resolver
amino_acid_sequence
MATLIFVDKDNEEPGRRLASKDGLKLGTGVKALDGKLQVSTPRVGKVFNAPAVPKASRKALGTVNRVAEKPMKTGKPLQPKQPTLTGKKITEKSTKTQSSVPAPDDAYPEIEKFFPFNPLDFESFDLPEEHQISLLPLNGVPLMTLNEERGLEKLLHLGPPSPLKTPFLSWESDPLYSPPSALSTLDVELPPVCYDADI
uniprot
proteins
function
FUNCTION: Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of p53/TP53. The negative regulation of p53/TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
21725
uniprot
proteins
mutagenesis
MUTAGEN 142; /note="P->A,L: Strongly reduces transactivation and transforming capability."; /evidence="ECO:0000269|PubMed:10713046
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-162 by CDC2 during mitosis. {ECO:0000250}.; PTM: Phosphorylated in vitro by ds-DNA kinase. {ECO:0000250}.; PTM: Ubiquitinated through 'Lys-11' linkage of ubiquitin moieties by the anaphase promoting complex (APC) at the onset of anaphase, conducting to its degradation. 'Lys-11'-linked ubiquitination is mediated by the E2 ligase UBE2C/UBCH10 (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Securin family
uniprot
proteins
pubmed
10713046
uniprot
proteins
pubmed
10727870
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
199
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
uniprot
proteins