PGRMC1
entrez
10857
canonical
uniprot
O00264
canonical
ensembl
ENSG00000101856
resolver
ensp
ENSP00000217971
resolver
ensp
ENSP00000442821
resolver
genesymbol
PGRMC1
resolver
genesymbol_syn
HPR6.6
resolver
genesymbol_syn
PGRMC
resolver
hgnc
HGNC:16090
resolver
uniprot
B7Z1L3
resolver
uniprot
Q6IB11
resolver
uniprot
Q9UGJ9
resolver
uniprot_entry
PGRC1_HUMAN
resolver
uniprot_entry
Q6IB11_HUMAN
resolver
uniprot_sec
B7Z1L3
resolver
uniprot_sec
Q9UGJ9
resolver
amino_acid_sequence
MAAEDVVATGADPSDLESGGLLHEIFTSPLNLLLLGLCIFLLYKIVRGDQPAASGDSDDDEPPPLPRLKRRDFTPAELRRFDGVQDPRILMAINGKVFDVTKGRKFYGPEGPYGVFAGRDASRGLATFCLDKEALKDEYDDLSDLTAAQQETLSDWESQFTFKYHHVGKLLKEGEEPTVYSDEEEPKDESARKND
uniprot
proteins
function
FUNCTION: Component of a progesterone-binding protein complex (PubMed:28396637). Binds progesterone (PubMed:25675345). Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins (PubMed:27599036). Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization (PubMed:30443021). {ECO:0000250|UniProtKB:O55022, ECO:0000269|PubMed:25675345, ECO:0000269|PubMed:27599036, ECO:0000269|PubMed:30443021, ECO:0000303|PubMed:28396637}.
uniprot
proteins
mass_dalton
21671
uniprot
proteins
mutagenesis
MUTAGEN 113; /note="Y->F: Abolishes interaction with CYP1A1 and CYP3A4."; /evidence="ECO:0000269|PubMed:26988023
uniprot
proteins
post_translational_modification
PTM: O-glycosylated; contains chondroitin sulfate attached to Ser-54. Ser-54 is in the cytoplasmic domain but the glycosylated form was detected in urine, suggesting that the membrane-bound form is cleaved, allowing for production of a secreted form which is glycosylated. {ECO:0000269|PubMed:36213313, ECO:0000269|PubMed:37453717}.
uniprot
proteins
protein_family
Cytochrome b5 family
uniprot
proteins
protein_family
MAPR subfamily
uniprot
proteins
pubmed
11697142
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17487921
uniprot
proteins
pubmed
17924679
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19367720
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21730960
uniprot
proteins
pubmed
22292588
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23763432
uniprot
proteins
pubmed
23793472
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25675345
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26988023
uniprot
proteins
pubmed
27599036
uniprot
proteins
pubmed
28007569
uniprot
proteins
pubmed
28396637
uniprot
proteins
pubmed
28559337
uniprot
proteins
pubmed
30443021
uniprot
proteins
pubmed
36213313
uniprot
proteins
pubmed
37047353
uniprot
proteins
pubmed
37453717
uniprot
proteins
pubmed
9705155
uniprot
proteins
sequence_length
195
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000250|UniProtKB:Q95250}; Single-pass membrane protein {ECO:0000255}. Smooth endoplasmic reticulum membrane {ECO:0000303|PubMed:28396637}; Single-pass membrane protein {ECO:0000255}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:O55022}; Single-pass membrane protein {ECO:0000305}; Extracellular side {ECO:0000250|UniProtKB:O55022}. Secreted {ECO:0000269|PubMed:36213313, ECO:0000269|PubMed:37453717}. Note=Localized at cell membrane, probably in lipid rafts, in serum-starved conditions. {ECO:0000269|PubMed:30443021}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..43; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins