Dmap1
entrez
66233
canonical
uniprot
Q9JI44
canonical
ensembl
ENSMUSG00000009640
resolver
ensp
ENSMUSP00000099748
resolver
ensp
ENSMUSP00000249844
resolver
ensp
ENSMUSP00000249845
resolver
ensp
ENSMUSP00000249849
resolver
genesymbol
Dmap1
resolver
genesymbol_syn
Mmtr
resolver
uniprot
Q99LM0
resolver
uniprot
Q9CSS9
resolver
uniprot
Q9DB33
resolver
uniprot_entry
DMAP1_MOUSE
resolver
uniprot_sec
Q99LM0
resolver
uniprot_sec
Q9CSS9
resolver
uniprot_sec
Q9DB33
resolver
amino_acid_sequence
MATGADVRDILELGGPEGDAASGTISKKDIINPDKKKSKKSSETLTFKRPEGMHREVYALLYSDKKDAPPLLPSDTGQGYRTVKAKLGSKKVRPWKWMPFTNPARKDGAMFFHWRRAAEEGKDYPFARFNKTVQVPVYSEQEYQLYLHDDAWTKAETDHLFDLSRRFDLRFVVIHDRYDHQQFKKRSVEDLKERYYHICAKLANVRAVPGTDLKIPVFDAGHERRRKEQLERLYNRTPEQVAEEEYLLQELRKIEARKKEREKRSQDLQKLITAADTTAEQRRTERKAPKKKLPQKKEAEKPAVPETAGIKFPDFKSAGVTLRSQRMKLPSSVGQKKIKALEQMLLELGVELSPTPTEELVHMFNELRSDLVLLYELKQACANCEYELQMLRHRHEALARAGVLGAPAAAAVGPTPASAEPTVSESGLGLDPTKDTIIDVVGAPLTPNSRKRRESASSSSSVKKAKKP
uniprot
proteins
function
FUNCTION: Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:14978102}.
uniprot
proteins
mass_dalton
53130
uniprot
proteins
pubmed
10888872
uniprot
proteins
pubmed
14978102
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
468
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm {ECO:0000250}. Note=Targeted to replication foci throughout S phase by DNMT1.
uniprot
proteins