CEACAM6
entrez
4680
canonical
uniprot
P40199
canonical
ensembl
ENSG00000086548
resolver
ensp
ENSP00000199764
resolver
ensp
ENSP00000788995
resolver
enst
ENST00000199764
resolver
genesymbol
CEACAM6
resolver
genesymbol_syn
NCA
resolver
hgnc
HGNC:1818
resolver
uniprot
Q13774
resolver
uniprot
Q14920
resolver
uniprot
Q53XP7
resolver
uniprot_entry
CEAM6_HUMAN
resolver
uniprot_sec
Q13774
resolver
uniprot_sec
Q14920
resolver
uniprot_sec
Q53XP7
resolver
amino_acid_sequence
MGPPSAPPCRLHVPWKEVLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLAHNLPQNRIGYSWYKGERVDGNSLIVGYVIGTQQATPGPAYSGRETIYPNASLLIQNVTQNDTGFYTLQVIKSDLVNEEATGQFHVYPELPKPSISSNNSNPVEDKDAVAFTCEPEVQNTTYLWWVNGQSLPVSPRLQLSNGNMTLTLLSVKRNDAGSYECEIQNPASANRSDPVTLNVLYGPDVPTISPSKANYRPGENLNLSCHAASNPPAQYSWFINGTFQQSTQELFIPNITVNNSGSYMCQAHNSATGLNRTTVTMITVSGSAPVLSAVATVGITIGVLARVALI
uniprot
proteins
function
FUNCTION: Cell surface glycoprotein that plays a role in cell adhesion and tumor progression (PubMed:10910050, PubMed:11590190, PubMed:1378450, PubMed:16204051, PubMed:2022629, PubMed:2803308, PubMed:8776764). Intercellular adhesion occurs in a calcium- and fibronectin-independent manner (PubMed:16204051, PubMed:2022629). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM5 and CEACAM8 (PubMed:11590190, PubMed:16204051, PubMed:2022629, PubMed:2803308, PubMed:8776764). Heterophilic interaction with CEACAM8 occurs in activated neutrophils (PubMed:8776764). Plays a role in neutrophil adhesion to cytokine-activated endothelial cells (PubMed:1378450). Plays a role in cell migration and cell adhesion to endothelial cells (PubMed:16204051). {ECO:0000269|PubMed:10910050, ECO:0000269|PubMed:11590190, ECO:0000269|PubMed:1378450, ECO:0000269|PubMed:16204051, ECO:0000269|PubMed:2022629, ECO:0000269|PubMed:2803308, ECO:0000269|PubMed:8776764}.
uniprot
proteins
mass_dalton
37237
uniprot
proteins
mutagenesis
MUTAGEN 38; /note="I->A: Loss of homodimerization and heterodimerization with CEACAM8."; /evidence="ECO:0000269|PubMed:26483485"; MUTAGEN 53; /note="L->A: No effect on homodimerization. Reduces heterodimerization with CEACAM8."; /evidence="ECO:0000269|PubMed:26483485"; MUTAGEN 55; /note="A->V: No effect on homophilic and heterophilic cell adhesion."; /evidence="ECO:0000269|PubMed:11590190"; MUTAGEN 61; /note="N->H: Inhibits homophilic and heterophilic cell adhesion."; /evidence="ECO:0000269|PubMed:11590190"; MUTAGEN 62; /note="R->L: No effect on homophilic cell adhesion. Reduces heterophilic cell adhesion."; /evidence="ECO:0000269|PubMed:11590190"; MUTAGEN 63; /note="I->F: No effect on homophilic cell adhesion. Inhibits heterophilic cell adhesion."; /evidence="ECO:0000269|PubMed:11590190"; MUTAGEN 66; /note="S->N: Inhibits homophilic cell adhesion. Reduces heterophilic cell adhesion."; /evidence="ECO:0000269|PubMed:11590190"; MUTAGEN 78; /note="L->Q: Inhibits homophilic cell adhesion. No effect on heterophilic cell adhesion."; /evidence="ECO:0000269|PubMed:11590190"; MUTAGEN 123; /note="Q->A: No effect on homodimerization. Reduces heterodimerization with CEACAM8."; /evidence="ECO:0000269|PubMed:26483485"; MUTAGEN 129; /note="L->A: Reduces homodimerization. Loss of heterodimerization with CEACAM8."; /evidence="ECO:0000269|PubMed:26483485
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:26483485}.
uniprot
proteins
protein_family
CEA family
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
10436421
uniprot
proteins
pubmed
10910050
uniprot
proteins
pubmed
11590190
uniprot
proteins
pubmed
1378450
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14724575
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16204051
uniprot
proteins
pubmed
16740002
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
2022629
uniprot
proteins
pubmed
2317824
uniprot
proteins
pubmed
26483485
uniprot
proteins
pubmed
2803308
uniprot
proteins
pubmed
2830274
uniprot
proteins
pubmed
3220478
uniprot
proteins
pubmed
3337731
uniprot
proteins
pubmed
36765147
uniprot
proteins
pubmed
8776764
uniprot
proteins
sequence_length
344
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:2317824}. Apical cell membrane {ECO:0000269|PubMed:10436421}. Cell surface {ECO:0000269|PubMed:1378450, ECO:0000269|PubMed:16204051, ECO:0000269|PubMed:2317824, ECO:0000269|PubMed:8776764, ECO:0000305|PubMed:2803308}. Note=Localized to the apical glycocalyx surface. {ECO:0000269|PubMed:10436421}.
uniprot
proteins