CSNK2B
entrez
1460
canonical
uniprot
P67870
canonical
ensembl
ENSG00000204435
resolver
ensembl
ENSG00000206406
resolver
ensembl
ENSG00000224398
resolver
ensembl
ENSG00000224774
resolver
ensembl
ENSG00000228875
resolver
ensembl
ENSG00000230700
resolver
ensembl
ENSG00000232960
resolver
ensp
ENSP00000365025
resolver
ensp
ENSP00000365026
resolver
ensp
ENSP00000365042
resolver
ensp
ENSP00000372919
resolver
ensp
ENSP00000372925
resolver
ensp
ENSP00000382980
resolver
ensp
ENSP00000390900
resolver
ensp
ENSP00000391038
resolver
ensp
ENSP00000393756
resolver
ensp
ENSP00000394855
resolver
ensp
ENSP00000395275
resolver
ensp
ENSP00000400188
resolver
ensp
ENSP00000407018
resolver
ensp
ENSP00000407379
resolver
ensp
ENSP00000409510
resolver
ensp
ENSP00000410802
resolver
ensp
ENSP00000411322
resolver
ensp
ENSP00000412520
resolver
ensp
ENSP00000413469
resolver
ensp
ENSP00000415237
resolver
ensp
ENSP00000415303
resolver
ensp
ENSP00000671935
resolver
enst
ENST00000375865
resolver
enst
ENST00000375866
resolver
enst
ENST00000375882
resolver
enst
ENST00000383427
resolver
enst
ENST00000383433
resolver
enst
ENST00000400110
resolver
enst
ENST00000412802
resolver
enst
ENST00000418230
resolver
enst
ENST00000422567
resolver
enst
ENST00000429633
resolver
enst
ENST00000431476
resolver
enst
ENST00000436169
resolver
enst
ENST00000443673
resolver
enst
ENST00000448596
resolver
enst
ENST00000451917
resolver
enst
ENST00000452985
resolver
enst
ENST00000453234
resolver
enst
ENST00000454382
resolver
enst
ENST00000454511
resolver
enst
ENST00000455161
resolver
enst
ENST00000458330
resolver
genesymbol
CSNK2B
resolver
genesymbol_syn
CK2N
resolver
genesymbol_syn
G5A
resolver
hgnc
HGNC:2460
resolver
uniprot
B0UXA9
resolver
uniprot
N0E4C7
resolver
uniprot
P07312
resolver
uniprot
P13862
resolver
uniprot
Q4VX47
resolver
uniprot_entry
CSK2B_HUMAN
resolver
uniprot_entry
N0E4C7_HUMAN
resolver
uniprot_sec
B0UXA9
resolver
uniprot_sec
P07312
resolver
uniprot_sec
P13862
resolver
uniprot_sec
Q4VX47
resolver
amino_acid_sequence
MSSSEEVSWISWFCGLRGNEFFCEVDEDYIQDKFNLTGLNEQVPHYRQALDMILDLEPDEELEDNPNQSDLIEQAAEMLYGLIHARYILTNRGIAQMLEKYQQGDFGYCPRVYCENQPMLPIGLSDIPGEAMVKLYCPKCMDVYTPKSSRHHHTDGAYFGTGFPHMLFMVHPEYRPKRPANQFVPRLYGFKIHPMAYQLQLQAASNFKSPVKTIR
uniprot
proteins
disease_involvement
DISEASE: Poirier-Bienvenu neurodevelopmental syndrome (POBINDS) [MIM:618732]: An autosomal dominant neurodevelopmental disorder characterized by onset of seizures in infancy, developmental delay, impaired intellectual development, and poor or absent speech. {ECO:0000269|PubMed:28585349, ECO:0000269|PubMed:31784560}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine (PubMed:11239457, PubMed:16818610). Participates in Wnt signaling (By similarity). {ECO:0000250|UniProtKB:P67871, ECO:0000269|PubMed:11239457, ECO:0000269|PubMed:16818610}.; FUNCTION: (Microbial infection) Upon infection with Epstein-Barr virus (EBV), the interaction with viral EBNA1 increases the association of CK2 with PML proteins, which increases PML phosphorylation by CK2, triggering the polyubiquitylation and degradation of PML (PubMed:20719947, PubMed:24216761). Seems to also suppress EBV reactivation by mediating ARK2N and JUN at the Z promoter which inhibits BZLF1 transcription (PubMed:31341047). {ECO:0000269|PubMed:20719947, ECO:0000269|PubMed:24216761, ECO:0000269|PubMed:31341047}.
uniprot
proteins
mass_dalton
24942
uniprot
proteins
mutagenesis
MUTAGEN 147..150; /note="KSSR->AAAA: No effect on interaction alpha subunit CSNK2A1. Loss on interaction with ARK2N and Epstein-Barr virus EBNA1."; /evidence="ECO:0000269|PubMed:24216761
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by alpha subunit. {ECO:0000269|PubMed:11574463, ECO:0000269|PubMed:2300566}.
uniprot
proteins
protein_family
Casein kinase 2 subunit beta family
uniprot
proteins
pubmed
10357806
uniprot
proteins
pubmed
11239457
uniprot
proteins
pubmed
11298324
uniprot
proteins
pubmed
11574463
uniprot
proteins
pubmed
11964394
uniprot
proteins
pubmed
12102635
uniprot
proteins
pubmed
12393879
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14656967
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16818610
uniprot
proteins
pubmed
1694965
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
1856204
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20719947
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
2300566
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24216761
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2513884
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
2666134
uniprot
proteins
pubmed
28585349
uniprot
proteins
pubmed
31341047
uniprot
proteins
pubmed
31784560
uniprot
proteins
sequence_length
215
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31341047}.
uniprot
proteins