Lmnb2
entrez
16907
canonical
uniprot
P21619
canonical
ensembl
ENSMUSG00000062075
resolver
ensp
ENSMUSP00000057291
resolver
ensp
ENSMUSP00000100969
resolver
ensp
ENSMUSP00000136524
resolver
enst
ENSMUST00000057623
resolver
genesymbol
Lmnb2
resolver
uniprot
A0A0R4J0Q5
resolver
uniprot
P48680
resolver
uniprot
Q3V159
resolver
uniprot
Q8CGB1
resolver
uniprot_entry
A0A0R4J0Q5_MOUSE
resolver
uniprot_entry
LMNB2_MOUSE
resolver
uniprot_entry
Q3V159_MOUSE
resolver
uniprot_sec
P48680
resolver
uniprot_sec
Q8CGB1
resolver
amino_acid_sequence
MASLPPHAGPATPLSPTRLSRLQEKEELRELNDRLAHYIDRVRALELENDRLLLRISEKEEVTTREVSGIKTLYESELADARRVLDETARERARLQIEIGKVQAELEEARKSAKKREGELTVAQGRVKDLESLFHRSEAELATALSDKQGLETEVAELRAQLAKAEDGHAVAKKQLEKETLMRVDLENRCQSLQEELAFSKSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMAQALEDLRSQHDEQVRLYRVELEQTYQAKLDNAKLLSDQNDKAAHAAREELKEARMRVESLSYQLLGLQKQASAAENHIHELEEALAGERDKFRKMLDAKEQEMTEVRDAMQQQLAEYQELLDIKLALDMEISAYRKLLEGEEERLKLSPSPSSRITISRATSSSSSSSGVGMSVGQGRGKRRRLETEDTSGSPSRASRVSSGSRLAQQTVATGVVNIDEVDPEGRFVRLKNSSDKDQSLGNWRIKRQVLEGEDIAYKFTPKYVLRAGQTVTVWAAGAGATHSPPSTLVWKSQTNWGPGESFRTALVSADGEEVAVKAAKHSSVQGRENGEEEEEEEAEFGEEDLFHQQGDPRTTSRGCRLM
uniprot
proteins
function
FUNCTION: Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane (PubMed:28241138). Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics (PubMed:28241138). The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively (PubMed:28241138). {ECO:0000269|PubMed:28241138}.
uniprot
proteins
mass_dalton
67318
uniprot
proteins
post_translational_modification
PTM: B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations. {ECO:0000250|UniProtKB:P20700}.; PTM: Phosphorylation plays a key role in lamin organization, subcellular localization and nuclear envelope disintegration (By similarity). Phosphorylation by CDK1 at Ser-15 and Ser-385 at the onset of mitosis drives lamin disassembly and nuclear envelope breakdown (By similarity). {ECO:0000250|UniProtKB:P02545}.
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
18230648
uniprot
proteins
pubmed
1939065
uniprot
proteins
pubmed
2102440
uniprot
proteins
pubmed
2102682
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2311764
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
28241138
uniprot
proteins
pubmed
8094052
uniprot
proteins
sequence_length
596
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus lamina {ECO:0000269|PubMed:28241138}.
uniprot
proteins