Q3UWQ3
uniprot
Q3UWQ3
canonical
amino_acid_sequence
MLTLASKLKWDEDLKGSQTSVSTSDSTRRFSMRDKLLVTEVAELEANLPWTCKVHFPDPNKLHCFQLTVSPDEGYYQGGNFQFEIEVPDAYNMVPPKVKCLTKIWHPNITETGEICLSLLREHSADGTGWAPTRTLKDVVWGLNSLFTDLLNFYDPLNIEAAEHHLQDKEDFRDKVDEYIRRYAR
uniprot
proteins
ec_number
2.3.2.34
uniprot
proteins
function
FUNCTION: Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. Together with the E3 ubiquitin ligase RNF7/RBX2, specifically neddylates cullin-5 (CUL5). Does not neddylate CUL1, CUL2, CUL3, CUL4A or CUL4B. Mediates neddylation of the CUL9-RBX1 complex (By similarity). {ECO:0000250|UniProtKB:Q969M7}.
uniprot
proteins
mass_dalton
21352
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein neddylation. {ECO:0000250|UniProtKB:Q969M7}.
uniprot
proteins
post_translational_modification
PTM: The acetylation of Met-1 increases affinity for DCUN1D3 by about 2 orders of magnitude and is crucial for NEDD8 transfer to cullins. {ECO:0000250|UniProtKB:Q969M7}.
uniprot
proteins
protein_family
UBE2F subfamily
uniprot
proteins
protein_family
Ubiquitin-conjugating enzyme family
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
185
uniprot
proteins