Nit1
entrez
27045
canonical
uniprot
Q8VDK1
canonical
ensembl
ENSMUSG00000013997
resolver
ensp
ENSMUSP00000106920
resolver
ensp
ENSMUSP00000106926
resolver
ensp
ENSMUSP00000358385
resolver
genesymbol
Nit1
resolver
uniprot
O88526
resolver
uniprot
Q9R1N4
resolver
uniprot_entry
NIT1_MOUSE
resolver
uniprot_sec
O88526
resolver
uniprot_sec
Q9R1N4
resolver
amino_acid_sequence
MLGFITRPPHQLLCTGYRLLRTPVLCTQPRPRTMSSSTSWELPLVAVCQVTSTPNKQENFKTCAELVQEAARLGACLAFLPEAFDFIARNPAETLLLSEPLNGDLLGQYSQLARECGIWLSLGGFHERGQDWEQNQKIYNCHVLLNSKGSVVASYRKTHLCDVEIPGQGPMRESNYTKPGGTLEPPVKTPAGKVGLAICYDMRFPELSLKLAQAGAEILTYPSAFGSVTGPAHWEVLLRARAIESQCYVIAAAQCGRHHETRASYGHSMVVDPWGTVVARCSEGPGLCLARIDLHFLQQMRQHLPVFQHRRPDLYGSLGHPLS
uniprot
proteins
ec_number
3.5.1.128
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Possesses amidase activity toward deaminated ophthalmate in vitro (PubMed:28373563). Plays a role in cell growth and apoptosis: loss of expression promotes cell growth, resistance to DNA damage stress and increased incidence to NMBA-induced tumors. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells. {ECO:0000269|PubMed:16864578, ECO:0000269|PubMed:19395373, ECO:0000269|PubMed:19479888, ECO:0000269|PubMed:19595734, ECO:0000269|PubMed:19596042, ECO:0000269|PubMed:28373563}.
uniprot
proteins
mass_dalton
35705
uniprot
proteins
protein_family
Carbon-nitrogen hydrolase superfamily
uniprot
proteins
protein_family
NIT1/NIT2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16864578
uniprot
proteins
pubmed
19395373
uniprot
proteins
pubmed
19479888
uniprot
proteins
pubmed
19595734
uniprot
proteins
pubmed
19596042
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28373563
uniprot
proteins
pubmed
9671749
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:19479888, ECO:0000269|PubMed:28373563}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:19479888, ECO:0000269|PubMed:28373563}.
uniprot
proteins