Eif3b
entrez
288516
canonical
uniprot
Q4G061
canonical
ensembl
ENSRNOG00000001253
resolver
ensembl
ENSRNOG00055011690
resolver
ensembl
ENSRNOG00060029458
resolver
ensembl
ENSRNOG00065000134
resolver
ensp
ENSRNOP00000057188
resolver
ensp
ENSRNOP00055016021
resolver
ensp
ENSRNOP00060042534
resolver
ensp
ENSRNOP00065000230
resolver
enst
ENSRNOT00055019857
resolver
enst
ENSRNOT00060051124
resolver
enst
ENSRNOT00065000231
resolver
genesymbol
Eif3b
resolver
genesymbol_syn
Eif3s9
resolver
uniprot_entry
EIF3B_RAT
resolver
amino_acid_sequence
MQDAENVAAPEAAEERAEPARQQPVSESPPTDEAAGSGGSEVGRTEDAEEDAEARPEPEVRAKPAAQSEEETAASPAASPTPQSAQEPSAPGKAEAGGEQARHPSARAEEEGGSDGSAAEAEPRALENGEADEPSFSDPEDFVDDVSEEELLGDVLKDRPQEADGIDSVIVVDNVPQVGPDRLEKLKNVIHKIFSKFGKIINDYYPEEDGKTKGYIFLEYASPAHAVDAVKNADGYKLDKQHTFRVNLFTDFDKYMTISDEWDIPEKQPFKDLGNLRYWLEEAECRDQYSVIFESGDRTSIFWNDVKDPVSIEERARWTETYVRWSPKGTYLATFHQRGIALWGGDKFKQIQRFSHQGVQLIDFSPCERYLVTFSPLMDTQDDPQAIIIWDILTGHKKRGFHCESSAHWPIFKWSHDGKFFARMTLDTLSIYETPSMGLLDKKSLKISGIKDFSWSPGGNIIAFWVPEDKDIPARVTLMQLPTRQEIRVRNLFNVVDCKLHWQKNGDYLCVKVDRTPKGTQGVVTNFEIFRMREKQVPVDVVEMKETIIAFAWEPNGSKFAVLHGEAPRISVSFYHVKSNGKIELIKMFDKQQANTIFWSPQGQFVVLAGLRSMNGALAFVDTSDCTVMNIAEHYMASDVEWDPTGRYVVTSVSWWSHKVDNAYWLWTFQGRLLQKNNKDRFCQLLWRPRPPTLLSQDQIKQIKKDLKKYSKIFEQKDRLSQSKASKELVERRRTMMEDFRQYRKMAQELYMKQKNERLELRGGVDTDELDSNVDDWEEETIEFFVTEEVIPLGSQE
uniprot
proteins
function
FUNCTION: RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. {ECO:0000255|HAMAP-Rule:MF_03001}.
uniprot
proteins
mass_dalton
90911
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation is enhanced upon serum stimulation. {ECO:0000255|HAMAP-Rule:MF_03001}.
uniprot
proteins
protein_family
EIF-3 subunit B family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16396499
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
797
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03001}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:P55884}. Note=Localizes to stress granules following cellular stress. {ECO:0000250|UniProtKB:P55884}.
uniprot
proteins