Hk2
entrez
25059
canonical
uniprot
P27881
canonical
ensembl
ENSRNOG00000006116
resolver
ensembl
ENSRNOG00055012250
resolver
ensembl
ENSRNOG00060002196
resolver
ensembl
ENSRNOG00065016667
resolver
ensp
ENSRNOP00000008813
resolver
ensp
ENSRNOP00055016824
resolver
ensp
ENSRNOP00060002347
resolver
ensp
ENSRNOP00065021899
resolver
enst
ENSRNOT00000008813
resolver
enst
ENSRNOT00055020846
resolver
enst
ENSRNOT00060003434
resolver
enst
ENSRNOT00065027778
resolver
genesymbol
Hk2
resolver
uniprot
Q9QWR1
resolver
uniprot_entry
HXK2_RAT
resolver
uniprot_sec
Q9QWR1
resolver
activity_regulation
ACTIVITY REGULATION: Hexokinase activity is specifically inhibited by 2,6-disubstituted glucosamines. {ECO:0000250|UniProtKB:P52789}.
uniprot
proteins
amino_acid_sequence
MIASHMIACLFTELNQNQVQKVDQFLYHMRLSDETLLEISRRFRKEMEKGLGATTHPTAAVKMLPTFVRSTPDGTEHGEFLALDLGGTNFRVLRVRVTDNGLQRVEMENQIYAIPEDIMRGSGTQLFDHIAECLANFMDKLQIKEKKLPLGFTFSFPCHQTKLDESFLVSWTKGFKSSGVEGRDVVDLIRKAIQRRGDFDIDIVAVVNDTVGTMMTCGYDDQNCEIGLIVGTGSNACYMEEMRHIDMVEGDEGRMCINMEWGAFGDDGTLNDIRTEFDREIDMGSLNPGKQLFEKMISGMYMGELVRLILVKMAKAELLFQGKLSPELLTTGSFETKDVSDIEEDKDGIEKAYQILMRLGLNPLQEDCVATHRICQIVSTRSASLCAATLAAVLWRIKENKGEERLRSTIGVDGSVYKKHPHFAKRLHKAVRRLVPDCDVRFLRSEDGSGKGAAMVTAVAYRLADQHRARQKTLESLKLSHEQLLEVKRRMKVEMEQGLSKETHAVAPVKMLPTYVCATPDGTEKGDFLALDLGGTNFRVLLVRVRNGKRRGVEMHNKIYSIPQEVMHGTGEELFDHIVQCIADFLEYMGMKGVSLPLGFTFSFPCQQNSLDQSILLKWTKGFKASGCEGEDVVTLLKEAIHRREEFDLDVVAVVNDTVGTMMTCGYEDPHCEVGLIVGTGSNACYMEEMRNVELVDGEEGRMCVNMEWGAFGDNGCLDDLRTVFDVAVDELSLNPGKQRFEKMISGMYLGEIVRNILIDFTKRGLLFRGRISERLKTRGIFETKFLSQIESDCLALLQVRAILRHLGLESTCDDSIIVKEVCTVVARRAAQLCGAGMAAVVDKIRENRGLDNLKVTVGVDGTLYKLHPHFAKVMHETVRDLAPKCDVSFLESEDGSGKGAALITAVACRIREAGQR
uniprot
proteins
ec_number
2.7.1.1
uniprot
proteins
function
FUNCTION: Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D-fructose 6-phosphate, respectively) (PubMed:5871820). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (PubMed:5871820). Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis (By similarity). {ECO:0000250|UniProtKB:P52789, ECO:0000269|PubMed:5871820}.
uniprot
proteins
mass_dalton
102544
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate metabolism; hexose metabolism. {ECO:0000305|PubMed:5871820}.; PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4. {ECO:0000305|PubMed:5871820}.
uniprot
proteins
protein_family
Hexokinase family
uniprot
proteins
pubmed
1897984
uniprot
proteins
pubmed
5871820
uniprot
proteins
pubmed
7044667
uniprot
proteins
pubmed
7622509
uniprot
proteins
pubmed
7873617
uniprot
proteins
sequence_length
917
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:P52789}; Peripheral membrane protein {ECO:0000250|UniProtKB:P52789}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P52789}. Note=The mitochondrial-binding peptide (MBP) region promotes association with the mitochondrial outer membrane. The interaction with the mitochondrial outer membrane via the mitochondrial-binding peptide (MBP) region promotes higher stability of the protein. Release from the mitochondrial outer membrane into the cytosol induces permeability transition pore (PTP) opening and apoptosis. {ECO:0000250|UniProtKB:P52789}.
uniprot
proteins