Cep63
entrez
300963
canonical
uniprot
Q4KLY0
canonical
ensembl
ENSRNOG00000008410
resolver
ensp
ENSRNOP00000029550
resolver
ensp
ENSRNOP00000070249
resolver
ensp
ENSRNOP00000083027
resolver
ensp
ENSRNOP00000092635
resolver
enst
ENSRNOT00000099786
resolver
genesymbol
Cep63
resolver
uniprot
A0A8I5ZV14
resolver
uniprot_entry
A0A8I5ZV14_RAT
resolver
uniprot_entry
CEP63_RAT
resolver
amino_acid_sequence
MEALLEGIQTRGHSGGFLTSCEAELQELMKQIDIMVAHKKSEWEGQTHALETCLDMRDRELKALRSQLDMKHKEVGILHQQIEEQEKTKQEMALEYKEELMKLQEELSRLKRSYEKLQKKQLREFRGNTKSLREDRSEIERLTGKIEEFRQKSLDWEKQRLIYQQQVSSLEAQRKALAEQSEIIQAQLANRKQKLESVELSSQSEIQHLSSKLERAKDTICANELEIERLNIRVKDLMGTNVTILQEQRQKEEKLRESEKLLEALQEEQKELKASLQAQESFILDAKMQEKLQTKLKAVDTKHSVERSLEDCQVERKYSSSGQGVLDNVLSQLDISHSSEELLQAEVTRLEGSLESVSTTCKQLSQELMEKYEELKRMEGHNNEYRTEIKKLKEQILQADQTYSSALEGMKTEISQLTRELHQRDITIASAKCSSSDMERQLKAEMQKAEEKAVEHKEILSQLESLRLENRRLSETVMKLELGLHECSMPVSPLGLIATRFLEEEELRSHHILERLDAHIEELKRESEKTVRQFTALV
uniprot
proteins
function
FUNCTION: Required for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned. Also recruits CDK1 to centrosomes. Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression. Promotes stabilization of FXR1 protein by inhibiting FXR1 ubiquitination. {ECO:0000250|UniProtKB:Q96MT8}.
uniprot
proteins
mass_dalton
62680
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated via 'Lys-48'-linked ubiquitin, leading to its degradation. Deubiquitinated by USP36, promoting its stabilization. {ECO:0000250|UniProtKB:Q96MT8}.
uniprot
proteins
protein_family
CEP63 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
538
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q3UPP8, ECO:0000250|UniProtKB:Q96MT8}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q3UPP8, ECO:0000250|UniProtKB:Q96MT8}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000250|UniProtKB:Q96MT8}. Note=Colocalizes with CDK5RAP2, CEP152 and WDR62 in a discrete ring around the proximal end of the parental centriole. At this site, a cohesive structure is predicted to engage parental centrioles and procentrioles (By similarity). {ECO:0000250|UniProtKB:Q3UPP8, ECO:0000250|UniProtKB:Q96MT8}.
uniprot
proteins