AURKC
entrez
6795
canonical
uniprot
Q9UQB9
canonical
ensembl
ENSG00000105146
resolver
ensp
ENSP00000302898
resolver
ensp
ENSP00000407162
resolver
ensp
ENSP00000471830
resolver
ensp
ENSP00000762677
resolver
genesymbol
AURKC
resolver
genesymbol_syn
AIE2
resolver
genesymbol_syn
AIK3
resolver
genesymbol_syn
AIRK3
resolver
genesymbol_syn
ARK3
resolver
genesymbol_syn
STK13
resolver
hgnc
HGNC:11391
resolver
uniprot
O60681
resolver
uniprot
O75442
resolver
uniprot
Q6AZY8
resolver
uniprot
Q6DLZ0
resolver
uniprot
Q9UPK5
resolver
uniprot_entry
AURKC_HUMAN
resolver
uniprot_sec
O60681
resolver
uniprot_sec
O75442
resolver
uniprot_sec
Q6AZY8
resolver
uniprot_sec
Q6DLZ0
resolver
uniprot_sec
Q9UPK5
resolver
activity_regulation
ACTIVITY REGULATION: Okadaic acid, an inhibitor of protein phosphatase 1 (PP1), protein phosphatase 2A (PP2A) and protein phosphatase 5 (PP5), increases AURKC activity. AURKC is also stabilized through its interaction with INCENP, which also acts as an activator. {ECO:0000269|PubMed:15316025}.
uniprot
proteins
amino_acid_sequence
MSSPRAVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDFEIGRPLGKGKFGNVYLARLKESHFIVALKVLFKSQIEKEGLEHQLRREIEIQAHLQHPNILRLYNYFHDARRVYLILEYAPRGELYKELQKSEKLDEQRTATIIEELADALTYCHDKKVIHRDIKPENLLLGFRGEVKIADFGWSVHTPSLRRKTMCGTLDYLPPEMIEGRTYDEKVDLWCIGVLCYELLVGYPPFESASHSETYRRILKVDVRFPLSMPLGARDLISRLLRYQPLERLPLAQILKHPWVQAHSRRVLPPCAQMAS
uniprot
proteins
disease_involvement
DISEASE: Spermatogenic failure 5 (SPGF5) [MIM:243060]: An infertility disorder caused by spermatogenesis defects. Semen from affected men show close to 100% morphologically abnormal multiflagellar spermatozoa with low motility, oversized irregular heads, and abnormal midpiece and acrosome. {ECO:0000269|PubMed:17435757, ECO:0000269|PubMed:21733974}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. {ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:15499654, ECO:0000269|PubMed:15670791, ECO:0000269|PubMed:15938719, ECO:0000269|PubMed:21493633, ECO:0000269|PubMed:21531210, ECO:0000269|PubMed:27332895}.
uniprot
proteins
mass_dalton
35591
uniprot
proteins
mutagenesis
MUTAGEN 72; /note="K->R: Impairs kinase activity."; /evidence="ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:15499654"; MUTAGEN 166; /note="D->Y: Impairs kinase activity, and keeps AURKC with the chromosomes until the end of mitosis."; /evidence="ECO:0000269|PubMed:15938719"; MUTAGEN 198; /note="T->A: Impairs kinase activity."; /evidence="ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:15670791
uniprot
proteins
protein_family
Aurora subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Ser/Thr protein kinase family
uniprot
proteins
pubmed
10066797
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15316025
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15499654
uniprot
proteins
pubmed
15670791
uniprot
proteins
pubmed
15938719
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17435757
uniprot
proteins
pubmed
21493633
uniprot
proteins
pubmed
21531210
uniprot
proteins
pubmed
21733974
uniprot
proteins
pubmed
27332895
uniprot
proteins
pubmed
9799611
uniprot
proteins
pubmed
9809744
uniprot
proteins
sequence_length
309
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Chromosome. Chromosome, centromere {ECO:0000269|PubMed:27332895}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:15938719}. Note=Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis. {ECO:0000269|PubMed:21531210}.
uniprot
proteins