ABCB9
entrez
23457
canonical
uniprot
Q9NP78
canonical
ensembl
ENSG00000150967
resolver
ensp
ENSP00000280559
resolver
ensp
ENSP00000280560
resolver
ensp
ENSP00000376234
resolver
ensp
ENSP00000440288
resolver
ensp
ENSP00000441734
resolver
ensp
ENSP00000456375
resolver
ensp
ENSP00000456813
resolver
genesymbol
ABCB9
resolver
genesymbol_syn
KIAA1520
resolver
hgnc
HGNC:50
resolver
uniprot
B4E2J0
resolver
uniprot
Q5W9G7
resolver
uniprot
Q769F3
resolver
uniprot
Q769F4
resolver
uniprot
Q96AB1
resolver
uniprot
Q9P208
resolver
uniprot_entry
ABCB9_HUMAN
resolver
uniprot_sec
B4E2J0
resolver
uniprot_sec
Q5W9G7
resolver
uniprot_sec
Q769F3
resolver
uniprot_sec
Q769F4
resolver
uniprot_sec
Q96AB1
resolver
uniprot_sec
Q9P208
resolver
activity_regulation
ACTIVITY REGULATION: Transport activity is limited by threshold levels of luminal peptide (PubMed:25646430). ATP hydrolysis is reduced in the presence of the spatial challenging 18-mer peptide by 50% and the branched 16-mer peptide by 75% (PubMed:31417173). Transport rate of the longer peptides is strongly reduced (PubMed:31417173). {ECO:0000269|PubMed:25646430, ECO:0000269|PubMed:31417173}.
uniprot
proteins
amino_acid_sequence
MRLWKAVVVTLAFMSVDICVTTAIYVFSHLDRSLLEDIRHFNIFDSVLDLWAACLYRSCLLLGATIGVAKNSALGPRRLRASWLVITLVCLFVGIYAMVKLLLFSEVRRPIRDPWFWALFVWTYISLGASFLLWWLLSTVRPGTQALEPGAATEAEGFPGSGRPPPEQASGATLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEPVANGSHKA
uniprot
proteins
ec_number
7.4.2.6
uniprot
proteins
function
FUNCTION: ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen for degradation (PubMed:15863492, PubMed:17977821, PubMed:18434309, PubMed:22641697, PubMed:25646430, PubMed:30353140, PubMed:30877195, PubMed:31417173). Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers (PubMed:15863492, PubMed:25646430). Binds and transports smaller and larger peptides with the same affinity (PubMed:31417173). Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored (PubMed:15863492, PubMed:17977821, PubMed:18434309). {ECO:0000269|PubMed:15863492, ECO:0000269|PubMed:17977821, ECO:0000269|PubMed:18434309, ECO:0000269|PubMed:22641697, ECO:0000269|PubMed:25646430, ECO:0000269|PubMed:30353140, ECO:0000269|PubMed:30877195, ECO:0000269|PubMed:31417173}.
uniprot
proteins
mass_dalton
84475
uniprot
proteins
mutagenesis
MUTAGEN 17; /note="D->N: Loss of lysosomal localization. Does not affect interaction between coreABCB9 and TMD0 domains. Does not affect dimerization. Does not affect peptide transport activity. Decreases interaction with YIF1B."; /evidence="ECO:0000269|PubMed:30877195"; MUTAGEN 17; /note="D->R: Loss of lysosomal localization. Does not affect lysosomal localization; when associated with D-57. Does not affect interaction between coreABCB9 and TMD0 domains. Does not affect interaction between coreABCB9 and TMD0 domains; when associated with D-57. Does not affect interaction between coreABCB9 and TMD0 domains; when associated with D-100."; /evidence="ECO:0000269|PubMed:30877195"; MUTAGEN 45; /note="D->K: Loss of lysosomal localization; when associated with K-49. Loss of lysosomal localization; when associated with K-49 and D-100. Does not affect peptide transport activity; when associated with K-49 and D-100."; /evidence="ECO:0000269|PubMed:30877195"; MUTAGEN 45; /note="D->N: Decreases lysosomal localization; when associated with N-49."; /evidence="ECO:0000269|PubMed:30877195"; MUTAGEN 49; /note="D->K: Loss of lysosomal localization; when associated with K-45. Loss of lysosomal localization; when associated with K-45 and D-100. Does not affect peptide transport activity; when associated with K-45 and D-100."; /evidence="ECO:0000269|PubMed:30877195"; MUTAGEN 49; /note="D->N: Decreases lysosomal localization; when associated with N-45."; /evidence="ECO:0000269|PubMed:30877195"; MUTAGEN 57; /note="R->A: Decreases lysosomal localization. Loss of lysosomal localization; when associated with A-100."; /evidence="ECO:0000269|PubMed:30877195"; MUTAGEN 57; /note="R->D: Loss of lysosomal localization. Does not affect lysosomal localization; when associated with R-17. Does not affect interaction between coreABCB9 and TMD0 domains. Does not affect interaction between coreABCB9 and TMD0 domains; when associated with R-17."; /evidence="ECO:0000269|PubMed:30877195"; MUTAGEN 100; /note="K->A: Decreases lysosomal localization. Loss of lysosomal localization; when associated with A-57."; /evidence="ECO:0000269|PubMed:30877195"; MUTAGEN 100; /note="K->D: Decreases lysosomal localization. Loss of lysosomal localization; when associated with R-17. Loss of lysosomal localization; when associated with K-45 and K-49. Does not affect peptide transport activity; when associated with K-45 and K-49. Does not affect interaction between coreABCB9 and TMD0 domains. Does not affect interaction between coreABCB9 and TMD0 domains; when associated with R-17."; /evidence="ECO:0000269|PubMed:30877195"; MUTAGEN 136..137; /note="LL->AA: No effect on lysosomal localization."; /evidence="ECO:0000269|PubMed:20377823"; MUTAGEN 545; /note="K->A: Loss of peptide transport activity; whena ssociated with A-699."; /evidence="ECO:0000269|PubMed:31417173"; MUTAGEN 699; /note="H->A: Loss of peptide transport activity; whena ssociated with A-545."; /evidence="ECO:0000269|PubMed:31417173
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCB family
uniprot
proteins
protein_family
MHC peptide exporter (TC 3.A.1.209) subfamily
uniprot
proteins
pubmed
10748049
uniprot
proteins
pubmed
10819331
uniprot
proteins
pubmed
11011155
uniprot
proteins
pubmed
11829140
uniprot
proteins
pubmed
13679046
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15491607
uniprot
proteins
pubmed
15577206
uniprot
proteins
pubmed
15863492
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17897319
uniprot
proteins
pubmed
17977821
uniprot
proteins
pubmed
18175933
uniprot
proteins
pubmed
18434309
uniprot
proteins
pubmed
18952056
uniprot
proteins
pubmed
20377823
uniprot
proteins
pubmed
21212514
uniprot
proteins
pubmed
22641697
uniprot
proteins
pubmed
25646430
uniprot
proteins
pubmed
30353140
uniprot
proteins
pubmed
30877195
uniprot
proteins
pubmed
31417173
uniprot
proteins
sequence_length
766
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:10748049, ECO:0000269|PubMed:15577206, ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:17977821, ECO:0000269|PubMed:18175933, ECO:0000269|PubMed:18952056, ECO:0000269|PubMed:20377823, ECO:0000269|PubMed:21212514, ECO:0000269|PubMed:22641697, ECO:0000269|PubMed:30877195}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441, ECO:0000269|PubMed:10748049, ECO:0000269|PubMed:15577206, ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:17977821, ECO:0000269|PubMed:18175933, ECO:0000269|PubMed:18952056, ECO:0000269|PubMed:20377823, ECO:0000269|PubMed:21212514}. Note=May be located in membrane rafts. Takes an intracellular route from the endoplasmic reticulum (ER), via Golgi and early endosomes to late endosomal and lysosomal compartments (PubMed:30877195). {ECO:0000269|PubMed:30877195}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..27; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 47..67; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 84..104; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 116..136; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 185..205; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 225..245; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 319..339; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 416..436; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00441
uniprot
proteins