Nit1
entrez
289222
canonical
uniprot
Q7TQ94
canonical
ensembl
ENSRNOG00000003881
resolver
ensp
ENSRNOP00000005194
resolver
ensp
ENSRNOP00000096370
resolver
genesymbol
Nit1
resolver
uniprot
Q5PQK6
resolver
uniprot_entry
NIT1_RAT
resolver
uniprot_sec
Q5PQK6
resolver
amino_acid_sequence
MLGFITRPPHQLLSLLCTGYRLPQISVLCTQPRPRAMAESSSTSWELPLVAVCQVTSTPNKQENFKTCAELVQEATRLGACLAFLPEAFDFIARNPAETLLLSEPLDGDLLGQYSQLARECGIWLSLGGFHERGQDWEQTQKIYNCHVLLNSKGSVVASYRKTHLCDVEIPGQGPMRESNYTMPGYALEPPVKTPAGKVGLAICYDMRFPELSLKLAQAGAEILTYPSAFGSVTGPAHWEVLLRARAIESQCYVIAAAQCGRHHETRASYGHSMVVDPWGTVVASCSEGPGLCLARIDLHFLQQMRQHLPVFQHRRPDLYGSLLPLS
uniprot
proteins
ec_number
3.5.1.128
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Plays a role in cell growth and apoptosis: loss of expression promotes cell growth, resistance to DNA damage stress and increased incidence to NMBA-induced tumors. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells. {ECO:0000250|UniProtKB:Q8VDK1}.
uniprot
proteins
mass_dalton
36094
uniprot
proteins
protein_family
Carbon-nitrogen hydrolase superfamily
uniprot
proteins
protein_family
NIT1/NIT2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
327
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion {ECO:0000250|UniProtKB:Q8VDK1}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000250|UniProtKB:Q8VDK1}.
uniprot
proteins