TLE4
entrez
7091
canonical
uniprot
Q04727
canonical
ensembl
ENSG00000106829
resolver
ensp
ENSP00000265284
resolver
ensp
ENSP00000365720
resolver
ensp
ENSP00000365727
resolver
ensp
ENSP00000365735
resolver
ensp
ENSP00000516378
resolver
ensp
ENSP00000635946
resolver
ensp
ENSP00000635947
resolver
ensp
ENSP00000635948
resolver
enst
ENST00000706431
resolver
genesymbol
TLE4
resolver
genesymbol_syn
GRG4
resolver
genesymbol_syn
KIAA1261
resolver
hgnc
HGNC:11840
resolver
uniprot
A0A994J7T6
resolver
uniprot
F8W6T6
resolver
uniprot
Q3ZCS1
resolver
uniprot
Q5T1Y2
resolver
uniprot
Q6PCB3
resolver
uniprot
Q9BZ07
resolver
uniprot
Q9BZ08
resolver
uniprot
Q9BZ09
resolver
uniprot
Q9NSL3
resolver
uniprot
Q9ULF9
resolver
uniprot_entry
A0A994J7T6_HUMAN
resolver
uniprot_entry
TLE4_HUMAN
resolver
uniprot_sec
F8W6T6
resolver
uniprot_sec
Q3ZCS1
resolver
uniprot_sec
Q5T1Y2
resolver
uniprot_sec
Q6PCB3
resolver
uniprot_sec
Q9BZ07
resolver
uniprot_sec
Q9BZ08
resolver
uniprot_sec
Q9BZ09
resolver
uniprot_sec
Q9NSL3
resolver
uniprot_sec
Q9ULF9
resolver
amino_acid_sequence
MIRDLSKMYPQTRHPAPHQPAQPFKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNAICAQVIPFLSQEHQQQVVQAVERAKQVTMAELNAIIGQQLQAQHLSHGHGLPVPLTPHPSGLQPPAIPPIGSSAGLLALSSALGGQSHLPIKDEKKHHDNDHQRDRDSIKSSSVSPSASFRGAEKHRNSADYSSESKKQKTEEKEIAARYDSDGEKSDDNLVVDVSNEDPSSPRGSPAHSPRENGLDKTRLLKKDAPISPASIASSSSTPSSKSKELSLNEKSTTPVSKSNTPTPRTDAPTPGSNSTPGLRPVPGKPPGVDPLASSLRTPMAVPCPYPTPFGIVPHAGMNGELTSPGAAYAGLHNISPQMSAAAAAAAAAAAYGRSPVVGFDPHHHMRVPAIPPNLTGIPGGKPAYSFHVSADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLDCLNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMENSNVEVLHVTKPDKYQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY
uniprot
proteins
function
FUNCTION: Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity). Involved in transcriptional repression of GNRHR and enhances MSX1-mediated transcriptional repression of CGA/alpha-GSU (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q62441}.
uniprot
proteins
mass_dalton
83755
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. PAX5 binding increases phosphorylation. {ECO:0000250|UniProtKB:Q62441}.; PTM: Ubiquitinated by XIAP/BIRC4. {ECO:0000269|PubMed:22304967}.
uniprot
proteins
protein_family
WD repeat Groucho/TLE family
uniprot
proteins
pubmed
10574462
uniprot
proteins
pubmed
1303260
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18254933
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21429299
uniprot
proteins
pubmed
22304967
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24676634
uniprot
proteins
sequence_length
773
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins