Coq7
entrez
25249
canonical
uniprot
Q63619
canonical
ensembl
ENSRNOG00000017012
resolver
ensp
ENSRNOP00000022988
resolver
genesymbol
Coq7
resolver
uniprot
G3V879
resolver
uniprot
O08887
resolver
uniprot_entry
COQ7_RAT
resolver
uniprot_sec
G3V879
resolver
uniprot_sec
O08887
resolver
amino_acid_sequence
MSGAGAIAAASVGCLRTGVPRPFSAYGRGLIIRCHSTGMTLDNINRAAVDQIIRVDHAGEYGANRIYAGQMAVLGRTSVGPVIQKMWDQEKNHLKKFNELMVAFRVRPTVLMPLWNVAGFALGAGTALLGKEGAMACTVAVEESIAHHYNNQIRMLMEEDAEKYEELLQVIKQFRDEELEHHDTGLEHDAELAPAYTLLKRLIQAGCSAAIYLSERF
uniprot
proteins
ec_number
1.14.13.253
uniprot
proteins
function
FUNCTION: Catalyzes the hydroxylation of the 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzoquinone at the C6 position and participates in the biosynthesis of ubiquinone. Catalyzes the reaction through a substrate-mediated reduction pathway, whereby NADH shuttles electrons to 5-methoxy-2-methyl-3-(all-trans-decaprenyl)benzoquinone, which then transfers the electrons to the two Fe(3+) centers. The binding of 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzoquinone (DMQn) mediates reduction of the diiron center by nicotinamide adenine dinucleotide (NADH) and initiates oxygen activation for subsequent DMQ hydroxylation. The physiological substrates are 5-methoxy-2-methyl-3-(all-trans-nonaprenyl)benzoquinone (DMQ(9)) and 5-methoxy-2-methyl-3-(all-trans-decaprenyl)benzoquinone (DMQ(10)), however in vitro the enzyme does not have any specificity concerning the length of the polyprenyl tail, and accepts tails of various lengths with similar efficiency (By similarity). Also has a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner (By similarity). Plays a role in modulating mitochondrial stress responses, acting in the nucleus, perhaps via regulating gene expression, independent of its characterized mitochondrial function in ubiquinone biosynthesis (By similarity). {ECO:0000250|UniProtKB:Q99807, ECO:0000255|HAMAP-Rule:MF_03194}.
uniprot
proteins
mass_dalton
23870
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis. {ECO:0000255|HAMAP-Rule:MF_03194}.
uniprot
proteins
protein_family
COQ7 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
8660658
uniprot
proteins
sequence_length
217
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03194}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03194}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03194}.
uniprot
proteins