Becn1
entrez
56208
canonical
uniprot
O88597
canonical
ensembl
ENSMUSG00000035086
resolver
ensp
ENSMUSP00000040094
resolver
ensp
ENSMUSP00000119369
resolver
ensp
ENSMUSP00000128413
resolver
ensp
ENSMUSP00000221900
resolver
enst
ENSMUST00000041403
resolver
enst
ENSMUST00000130916
resolver
enst
ENSMUST00000170502
resolver
genesymbol
Becn1
resolver
uniprot
E9QAM0
resolver
uniprot
Q99J03
resolver
uniprot_entry
BECN1_MOUSE
resolver
uniprot_entry
E9QAM0_MOUSE
resolver
uniprot_sec
Q99J03
resolver
amino_acid_sequence
MEGSKASSSTMQVSFVCQRCSQPLKLDTSFKILDRVTIQELTAPLLTTAQAKPGETQEEEANSGEEPFIETRQDGVSRRFIPPARMMSTESANSFTLIGEASDGGTMENLSRRLKVTGDLFDIMSGQTDVDHPLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQLQRELKELALEEERLIQELEDVEKNRKVVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQLELDDELKSVENQVRYAQIQLDKLKKTNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKSKELPLYCSGGLRFFWDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDTGGSGGSYSIKTQFNSEEQWTKALKFMLTNLKWGLAWVSSQFYNK
uniprot
proteins
function
FUNCTION: Plays a central role in autophagy (PubMed:10604474, PubMed:12372286, PubMed:19270693, PubMed:28445460). Acts as a core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed:19270693, PubMed:25275521). Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms (PubMed:25275521). Involved in endocytosis including endosome formation in neuronal cells (PubMed:25275521). May play a role in antiviral host defense (By similarity). {ECO:0000250|UniProtKB:Q14457, ECO:0000269|PubMed:10604474, ECO:0000269|PubMed:12372286, ECO:0000269|PubMed:19270693, ECO:0000269|PubMed:25275521, ECO:0000269|PubMed:28445460}.; FUNCTION: Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors (By similarity). {ECO:0000250|UniProtKB:Q14457}.
uniprot
proteins
mass_dalton
51589
uniprot
proteins
mutagenesis
MUTAGEN 91; /note="S->A: Complete loss of phosphorylation. Complete loss of phosphorylation and defective autophagic function; when associated with Ala-94."; /evidence="ECO:0000269|PubMed:23332761"; MUTAGEN 94; /note="S->A: Partial loss of phosphorylation. Complete loss of phosphorylation and defective autophagic function; when associated with Ala-91."; /evidence="ECO:0000269|PubMed:23332761
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-117 by DAPK1 reduces its interaction with BCL2 and BCL2L1 and promotes induction of autophagy (By similarity). In response to autophagic stimuli, phosphorylated at serine residues by AMPK in an ATG14-dependent manner, and this phosphorylation is critical for maximally efficient autophagy. {ECO:0000250|UniProtKB:Q14457, ECO:0000269|PubMed:23332761}.; PTM: Polyubiquitinated by NEDD4, both with 'Lys-11'- and 'Lys-63'-linkages (By similarity). 'Lys-11'-linked polyubiquitination leads to degradation and is enhanced when the stabilizing interaction partner VPS34 is depleted (By similarity). Deubiquitinated by USP10 and USP13, leading to stabilize the PIK3C3/VPS34-containing complexes (By similarity). Polyubiquitinated at Lys-400 with 'Lys-48'-linkages (PubMed:28445460). 'Lys-48'-linked poyubiquitination of Lys-400 leads to degradation (PubMed:28445460). Deubiquitinated by ATXN3, leading to stabilization (PubMed:28445460). Ubiquitinated at Lys-435 via 'Lys-63'-linkage by the DCX(AMBRA1) complex, thereby increasing the association between BECN1 and PIK3C3 to promote PIK3C3 activity (By similarity). 'Lys-48'-linked ubiquitination by RNF216 leads to proteasomal degradation and autophagy inhibition (By similarity). {ECO:0000250|UniProtKB:Q14457, ECO:0000269|PubMed:28445460}.; PTM: Proteolytically processed by caspases including CASP8 and CASP3; the C-terminal fragments lack autophagy-inducing capacity and are proposed to induce apoptosis. Thus the cleavage is proposed to be an determinant to switch from autophagy to apoptosis pathways affecting cellular homeostasis including viral infections and survival of tumor cells. {ECO:0000305|PubMed:21364619}.
uniprot
proteins
protein_family
Beclin family
uniprot
proteins
pubmed
10604474
uniprot
proteins
pubmed
12372286
uniprot
proteins
pubmed
14657337
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17589504
uniprot
proteins
pubmed
18248095
uniprot
proteins
pubmed
19270693
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20819940
uniprot
proteins
pubmed
21059846
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21364619
uniprot
proteins
pubmed
22493499
uniprot
proteins
pubmed
23332761
uniprot
proteins
pubmed
25275521
uniprot
proteins
pubmed
28445460
uniprot
proteins
pubmed
29604308
uniprot
proteins
pubmed
34428398
uniprot
proteins
pubmed
9765397
uniprot
proteins
sequence_length
448
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12372286}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q14457}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14457}. Endosome membrane {ECO:0000250|UniProtKB:Q14457}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14457}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q14457}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14457}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q14457}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q14457}. Endosome {ECO:0000269|PubMed:25275521}. Cytoplasmic vesicle, autophagosome {ECO:0000305}. Note=Interaction with ATG14 promotes translocation to autophagosomes (By similarity). Expressed in dendrites and cell bodies of cerebellar Purkinje cells. Localized to endosomes in neurons (PubMed:25275521). {ECO:0000250|UniProtKB:Q14457, ECO:0000269|PubMed:12372286, ECO:0000269|PubMed:25275521}.; SUBCELLULAR LOCATION: [Beclin-1-C 35 kDa]: Mitochondrion {ECO:0000269|PubMed:21364619}. Nucleus {ECO:0000250|UniProtKB:Q14457}. Cytoplasm {ECO:0000250|UniProtKB:Q14457}.; SUBCELLULAR LOCATION: [Beclin-1-C 37 kDa]: Mitochondrion {ECO:0000269|PubMed:21364619}.
uniprot
proteins