LIPH
entrez
200879
canonical
uniprot
Q8WWY8
canonical
ensembl
ENSG00000163898
resolver
ensp
ENSP00000296252
resolver
ensp
ENSP00000396384
resolver
ensp
ENSP00000567693
resolver
enst
ENST00000296252
resolver
enst
ENST00000424591
resolver
genesymbol
LIPH
resolver
genesymbol_syn
LPDLR
resolver
genesymbol_syn
MPAPLA1
resolver
genesymbol_syn
PLA1B
resolver
hgnc
HGNC:18483
resolver
uniprot
A2IBA6
resolver
uniprot
A2IBA7
resolver
uniprot
F6RI74
resolver
uniprot
Q8TEC7
resolver
uniprot_entry
A2IBA6_HUMAN
resolver
uniprot_entry
F6RI74_HUMAN
resolver
uniprot_entry
LIPH_HUMAN
resolver
uniprot_sec
A2IBA7
resolver
uniprot_sec
Q8TEC7
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by sodium vanadate. {ECO:0000269|PubMed:12963729}.
uniprot
proteins
amino_acid_sequence
MLRFYLFISLLCLSRSDAEETCPSFTRLSFHSAVVGTGLNVRLMLYTRKNLTCAQTINSSAFGNLNVTKKTTFIVHGFRPTGSPPVWMDDLVKGLLSVEDMNVVVVDWNRGATTLIYTHASSKTRKVAMVLKEFIDQMLAEGASLDDIYMIGVSLGAHISGFVGEMYDGWLGRITGLDPAGPLFNGKPHQDRLDPSDAQFVDVIHSDTDALGYKEPLGNIDFYPNGGLDQPGCPKTILGGFQYFKCDHQRSVYLYLSSLRESCTITAYPCDSYQDYRNGKCVSCGTSQKESCPLLGYYADNWKDHLRGKDPPMTKAFFDTAEESPFCMYHYFVDIITWNKNVRRGDITIKLRDKAGNTTESKINHEPTTFQKYHQVSLLARFNQDLDKVAAISLMFSTGSLIGPRYKLRILRMKLRSLAHPERPQLCRYDLVLMENVETVFQPILCPELQL
uniprot
proteins
disease_involvement
DISEASE: Hypotrichosis 7 (HYPT7) [MIM:604379]: A condition characterized by the presence of less than the normal amount of hair. Affected individuals have sparse or absent scalp, axillary and body hair and sparse eyebrows and eyelashes. HYPT7 inheritance is autosomal recessive. {ECO:0000269|PubMed:17095700, ECO:0000269|PubMed:19167195}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Woolly hair autosomal recessive 2 (ARWH2) [MIM:604379]: A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrhexis nodosa and tapered ends. Some individuals may present with hypotrichosis. {ECO:0000269|PubMed:18830268, ECO:0000269|PubMed:21426374, ECO:0000269|PubMed:28425126}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.1.1.-
uniprot
proteins
function
FUNCTION: Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). {ECO:0000269|PubMed:12063250, ECO:0000269|PubMed:12963729}.
uniprot
proteins
mass_dalton
50859
uniprot
proteins
mutagenesis
MUTAGEN 154; /note="S->A: Loss of lipase activity."; /evidence="ECO:0000269|PubMed:12063250
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
protein_family
Lipase family
uniprot
proteins
pubmed
12063250
uniprot
proteins
pubmed
12213196
uniprot
proteins
pubmed
12719377
uniprot
proteins
pubmed
12963729
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17095700
uniprot
proteins
pubmed
18830268
uniprot
proteins
pubmed
19167195
uniprot
proteins
pubmed
21426374
uniprot
proteins
pubmed
28425126
uniprot
proteins
pubmed
32336749
uniprot
proteins
sequence_length
451
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12963729}. Cell membrane {ECO:0000269|PubMed:12063250, ECO:0000269|PubMed:12963729}; Peripheral membrane protein.
uniprot
proteins