Ric8a
entrez
101489
canonical
uniprot
Q3TIR3
canonical
ensembl
ENSMUSG00000025485
resolver
ensp
ENSMUSP00000026558
resolver
enst
ENSMUST00000026558
resolver
genesymbol
Ric8a
resolver
genesymbol_syn
Ric8
resolver
uniprot
Q3TEY3
resolver
uniprot
Q99JW0
resolver
uniprot
Q9ERR6
resolver
uniprot_entry
RIC8A_MOUSE
resolver
uniprot_sec
Q3TEY3
resolver
uniprot_sec
Q99JW0
resolver
uniprot_sec
Q9ERR6
resolver
amino_acid_sequence
MEPRAVADALETGEEDAVTEALRSFNREHSQSFTFDDAQQEDRKRLAKLLVSVLEQGLSPKHRVTWLQTIRILSRDRSCLDSFASRQSLHALACYADITVSEEPIPQSPDMDVLLESLKCLCNLVLSSPTAQMLAAEARLVVRLAERVGLYRKRSYPHEVQFFDLRLLFLLTALRTDVRQQLFQELHGVRLLTDALELTLGVAPKENPPVMLPAQETERAMEILKVLFNITFDSVKREVDEEDAALYRYLGTLLRHCVMVEAAGDRTEEFHGHTVNLLGNLPLKCLDVLLALELHEGSLEFMGVNMDVISALLAFLEKRLHQTHRLKECVAPVLNVLTECARMHRPARKFLKAQVLPPLRDVRTRPEVGDLLRNKLVRLMTHLDTDVKRVAAEFLFVLCSESVPRFIKYTGYGNAAGLLAARGLMAGGRPEGQYSEDEDTDTEEYREAKASINPVTGRVEEKPPNPMEGMTEEQKEHEAMKLVNMFDKLSRHRVIQPMGMSPRGHLTSLQDAMCETMEGQLSSDPDSDPD
uniprot
proteins
function
FUNCTION: Chaperone that specifically binds and folds nascent G alpha proteins prior to G protein heterotrimer formation, promoting their stability and activity: folds GNAI1, GNAO1, GNA13 and GNAQ (PubMed:22114146). Does not fold G(s) G-alpha proteins GNAS nor GNAL (PubMed:22114146). Also acts as a guanine nucleotide exchange factor (GEF) for G alpha proteins by stimulating exchange of bound GDP for free GTP (By similarity). Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein (GNAI1), possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation (By similarity). {ECO:0000250|UniProtKB:Q80ZG1, ECO:0000250|UniProtKB:Q9NPQ8, ECO:0000269|PubMed:22114146}.
uniprot
proteins
mass_dalton
59847
uniprot
proteins
protein_family
Synembryn family
uniprot
proteins
pubmed
10985349
uniprot
proteins
pubmed
12971991
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16221497
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21158412
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22114146
uniprot
proteins
pubmed
29844055
uniprot
proteins
sequence_length
530
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cell cortex {ECO:0000269|PubMed:22114146}. Cytoplasm {ECO:0000250|UniProtKB:Q80ZG1}.
uniprot
proteins