NOP58
entrez
51602
canonical
uniprot
Q9Y2X3
canonical
ensembl
ENSG00000055044
resolver
ensp
ENSP00000264279
resolver
enst
ENST00000264279
resolver
genesymbol
NOP58
resolver
genesymbol_syn
NOL5
resolver
genesymbol_syn
NOP5
resolver
hgnc
HGNC:29926
resolver
uniprot
Q53SA4
resolver
uniprot
Q6PK08
resolver
uniprot
Q9P036
resolver
uniprot
Q9UFN3
resolver
uniprot_entry
NOP58_HUMAN
resolver
uniprot_sec
Q53SA4
resolver
uniprot_sec
Q6PK08
resolver
uniprot_sec
Q9P036
resolver
uniprot_sec
Q9UFN3
resolver
amino_acid_sequence
MLVLFETSVGYAIFKVLNEKKLQEVDSLWKEFETPEKANKIVKLKHFEKFQDTAEALAAFTALMEGKINKQLKKVLKKIVKEAHEPLAVADAKLGGVIKEKLNLSCIHSPVVNELMRGIRSQMDGLIPGVEPREMAAMCLGLAHSLSRYRLKFSADKVDTMIVQAISLLDDLDKELNNYIMRCREWYGWHFPELGKIISDNLTYCKCLQKVGDRKNYASAKLSELLPEEVEAEVKAAAEISMGTEVSEEDICNILHLCTQVIEISEYRTQLYEYLQNRMMAIAPNVTVMVGELVGARLIAHAGSLLNLAKHAASTVQILGAEKALFRALKSRRDTPKYGLIYHASLVGQTSPKHKGKISRMLAAKTVLAIRYDAFGEDSSSAMGVENRAKLEARLRTLEDRGIRKISGTGKALAKTEKYEHKSEVKTYDPSGDSTLPTCSKKRKIEQVDKEDEITEKKAKKAKIKVKVEEEEEEKVAEEEETSVKKKKKRGKKKHIKEEPLSEEEPCTSTAIASPEKKKKKKKKRENED
uniprot
proteins
function
FUNCTION: Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs (PubMed:15574333, PubMed:17636026, PubMed:19620283, PubMed:34516797). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) complexes that function in methylation of multiple sites on ribosomal RNAs (rRNAs) and messenger RNAs (mRNAs) (PubMed:39570315). {ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:17636026, ECO:0000269|PubMed:19620283, ECO:0000269|PubMed:34516797, ECO:0000269|PubMed:39570315}.
uniprot
proteins
mass_dalton
59578
uniprot
proteins
mutagenesis
MUTAGEN 283; /note="A->P: Restricted to nucleoplasm. Abolishes interaction with NOPCHAP1."; /evidence="ECO:0000269|PubMed:33367824"; MUTAGEN 310..313; /note="KHAA->AHAR: Restricted to nucleoplasm. Decreases interaction with NOPCHAP1."; /evidence="ECO:0000269|PubMed:33367824
uniprot
proteins
post_translational_modification
PTM: Sumoylation is essential for high-affinity binding to snoRNAs. {ECO:0000269|PubMed:20797632}.
uniprot
proteins
protein_family
NOP5/NOP56 family
uniprot
proteins
pubmed
10606270
uniprot
proteins
pubmed
10925205
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
12417735
uniprot
proteins
pubmed
12429849
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15574333
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17636026
uniprot
proteins
pubmed
17709390
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19620283
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20797632
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
33367824
uniprot
proteins
pubmed
34516797
uniprot
proteins
pubmed
39570315
uniprot
proteins
sequence_length
529
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:33367824, ECO:0000269|PubMed:34516797}. Nucleus, nucleoplasm {ECO:0000269|PubMed:33367824}. Note=Localizes to the nucleolus with a minor part present in the nucleoplasm. {ECO:0000269|PubMed:33367824}.
uniprot
proteins