CATSPER4
entrez
378807
canonical
uniprot
Q7RTX7
canonical
ensembl
ENSG00000188782
resolver
ensp
ENSP00000341006
resolver
ensp
ENSP00000390423
resolver
genesymbol
CATSPER4
resolver
hgnc
HGNC:23220
resolver
uniprot
A1A4W6
resolver
uniprot
Q5VY71
resolver
uniprot_entry
CTSR4_HUMAN
resolver
uniprot_sec
A1A4W6
resolver
uniprot_sec
Q5VY71
resolver
activity_regulation
ACTIVITY REGULATION: The CatSper calcium channel is indirectly activated by extracellular progesterone and prostaglandins following the sequence: progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2 (PubMed:21412338, PubMed:21412339, PubMed:26989199). The CatSper calcium channel is directly inhibited by endocannabinoid 2-arachidonoylglycerol (2AG) (PubMed:26989199). Indirect activation by progesterone takes place via the following mechanism: progesterone binds and activates the acylglycerol lipase ABHD2, which in turn mediates hydrolysis of 2AG inhibitor, relieving inhibition of the CatSper channel (PubMed:26989199). The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second messengers (PubMed:21412338, PubMed:21412339). Sperm capacitation enhances the effect of progesterone by providing additional negative shift. Also activated by the elevation of intracellular pH (PubMed:21412338, PubMed:21412339). {ECO:0000269|PubMed:21412338, ECO:0000269|PubMed:21412339, ECO:0000269|PubMed:26989199}.
uniprot
proteins
amino_acid_sequence
MRDNEKAWWQQWTSHTGLEGWGGTQEDRMGFGGAVAALRGRPSPLQSTIHESYGRPEEQVLINRQEITNKADAWDMQEFITHMYIKQLLRHPAFQLLLALLLVINAITIALRTNSYLDQKHYELFSTIDDIVLTILLCEVLLGWLNGFWIFWKDGWNILNFIIVFILLLRFFINEINIPSINYTLRALRLVHVCMAVEPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAFVPKHFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGINLFVIVVTTNLEQMMKAGEQGQQQRITFSETGAEEEEENDQLPLVHCVVARSEKSGLLQEPLAGGPLSNLSENTCDNFCLVLEAIQENLRQYKEIRDELNMIVEEVRAIRFNQEQESEVLNRRSSTSGSLETTSSKDIRQMSQQQDLLSALVSMEKVHDSSSQILLKKHKSSH
uniprot
proteins
function
FUNCTION: Pore-forming subunit of the CatSper complex, a sperm-specific voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. {ECO:0000269|PubMed:21412338, ECO:0000269|PubMed:21412339}.
uniprot
proteins
mass_dalton
54092
uniprot
proteins
protein_family
Cation channel sperm-associated (TC 1.A.1.19) family
uniprot
proteins
pubmed
12932298
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17347248
uniprot
proteins
pubmed
21412338
uniprot
proteins
pubmed
21412339
uniprot
proteins
pubmed
26989199
uniprot
proteins
sequence_length
472
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:Q8BVN3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8BVN3}. Note=Specifically located in the principal piece of the sperm tail. {ECO:0000250|UniProtKB:Q8BVN3}.
uniprot
proteins
transmembrane_region
TRANSMEM 91..112; /note="Helical; Name=Segment S1"; /evidence="ECO:0000250|UniProtKB:Q8BVN3"; TRANSMEM 123..149; /note="Helical; Name=Segment S2"; /evidence="ECO:0000250|UniProtKB:Q8BVN3"; TRANSMEM 154..177; /note="Helical; Name=Segment S3"; /evidence="ECO:0000250|UniProtKB:Q8BVN3"; TRANSMEM 181..199; /note="Helical; Name=Segment S4"; /evidence="ECO:0000250|UniProtKB:Q8BVN3"; TRANSMEM 213..236; /note="Helical; Name=Segment S5"; /evidence="ECO:0000250|UniProtKB:Q8BVN3"; TRANSMEM 280..307; /note="Helical; Name=Segment S6"; /evidence="ECO:0000250|UniProtKB:Q8BVN3
uniprot
proteins