Psmc1
entrez
117263
canonical
uniprot
P62193
canonical
ensembl
ENSRNOG00000003951
resolver
ensembl
ENSRNOG00055014985
resolver
ensembl
ENSRNOG00060004068
resolver
ensembl
ENSRNOG00065014401
resolver
ensp
ENSRNOP00000005329
resolver
ensp
ENSRNOP00055020933
resolver
ensp
ENSRNOP00060005148
resolver
ensp
ENSRNOP00065018534
resolver
enst
ENSRNOT00055025665
resolver
enst
ENSRNOT00060006845
resolver
enst
ENSRNOT00065023815
resolver
genesymbol
Psmc1
resolver
uniprot
P49014
resolver
uniprot
Q03527
resolver
uniprot
Q96AZ3
resolver
uniprot_entry
PRS4_RAT
resolver
uniprot_sec
P49014
resolver
uniprot_sec
Q03527
resolver
uniprot_sec
Q96AZ3
resolver
amino_acid_sequence
MGQSQSGGHGPGGGKKDDKDKKKKYEPPVPTRVGKKKKKTKGPDAASKLPLVTPHTQCRLKLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL
uniprot
proteins
function
FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000250|UniProtKB:P62191}.
uniprot
proteins
mass_dalton
49185
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8607789
uniprot
proteins
sequence_length
440
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Membrane {ECO:0000250|UniProtKB:P62191}; Lipid-anchor {ECO:0000250|UniProtKB:P62191}.
uniprot
proteins