Tex14
entrez
83560
canonical
uniprot
Q7M6U3
canonical
ensembl
ENSMUSG00000010342
resolver
ensp
ENSMUSP00000054444
resolver
ensp
ENSMUSP00000347384
resolver
ensp
ENSMUSP00000347386
resolver
ensp
ENSMUSP00000347390
resolver
genesymbol
Tex14
resolver
uniprot
B2KGL0
resolver
uniprot
Q3UT36
resolver
uniprot
Q5NC10
resolver
uniprot
Q5NC11
resolver
uniprot
Q8CGK1
resolver
uniprot
Q8CGK2
resolver
uniprot
Q99MV8
resolver
uniprot_entry
TEX14_MOUSE
resolver
uniprot_sec
B2KGL0
resolver
uniprot_sec
Q3UT36
resolver
uniprot_sec
Q5NC10
resolver
uniprot_sec
Q5NC11
resolver
uniprot_sec
Q8CGK1
resolver
uniprot_sec
Q8CGK2
resolver
uniprot_sec
Q99MV8
resolver
amino_acid_sequence
MSRGAPFPVPCPVLLGTFTDDSLEAQLHEYAKQGNCVKLKKILKKGVCVDAVNTQGQSALFVAALLGHVKLVDVLVDYGSDPNHRCFDGSTPVHAAAFSGNQWILSKLLTAGGDLRLHDEKGRNPQAWALTAGKDRSTQMVEFMQRCTSHMKAIIQGFSYDLLKKIDSPQRLIGSPPWFGSLIQGSPNSSPNRQLKPGIISAQNIYSFGFGKFYLTSGMQLTYPGSLPVIGEKEVVQADDEPTFSFFSGPYMVMTNLVWNRSRVTVKELNLPTRPHCSRLRLADLLIAEQEHSSNLRHPNLLQLMAVCLSRDLEKIRLVYERITVGTLFSVLHERRSQFPVLHMEVIVHLLLQVADALIYLHSRGFIHRSLSSYAVHIVSAGEARLTNLEYLTESQDSGAHRNVTRMPLPTQLYNWAAPEVVLQKAATVKSDIYSFSVIIQEILTDSIPWNGLDGSLVKETIALGNYLEADVRLPEPYYDIVKSGIHAKQKNRTMNLQDIRYILKNDLKEFIGAQKTQPTESPRGQSYEPHPDVNICLGLTSEYQKDPPDLDIKELKEMGSQPHSPTDHSFLTVKPTLAPQTLDSSLSAQKPDNANVPSPPAACLAEEVRSPTASQDSLCSFEINEIYSGCLTLGTDKEEECLGTAASPEGDRPNQGDELPSLEEELDKMERELHCFCEEDKSISEVDTDLLFEDDDWQSDSLGSLNLPEPTREAKGKTSSWSKTDEYVSKCVLNLKISQVMMQQSAEWLRKLEQEVEELEWAQKELDSQCSSLRDASLKFANAKFQPAVGPPSLAYLPPVMQLPGLKQPENGGTWLTLARSPGNEREFQEGHFSKKPEKLSACGWKPFTQVSEESRGDCSELNNQLPTLRGPGKQSTGEQLPSTQEARESLEKNTNQNSRSMASVSSEIYATKSRNNEDNGEAHLKWRLAVKEMAEKAVSGQLLLPPWNPQSSAPFESKVENESTPLPRPPIRGPESTEWQHILEYQRENDEPKGNTKFGKMDNSDCDKNKHSRWTGLQRFTGIRYPFFRNHEQPEQNEASQASCDTSVGTEKFYSTSSPIGDDFERFQDSFAQRQGYVEENFQIREIFEKNAEILTKPQFQAIQCAEDKQDETLGETPKELKEKNTSLTDIQDLSSITYDQDGYFKETSYKTPKLKHAPTSASTPLSPESISSAASHYEDCLENTTFHVKRGSTFCWNGQEAMRTLSAKFTTVRERAKSLESLLASSKSLPAKLTDSKRLCMLSETGSSNVSAAFVTSTHATKRKSLPRELAEATSQQHLDELPPPAQELLDEIEQLKQQQVSSLASHENTARDLSVTNKDKKHLEEQETNSSKDSSFLSSREIQDLEDTERAHSSLDEDLERFLQSPEENTALLDPTKGSTREKKNKDQDVVEQKRKKKESIKPERRESDSSLGTLEEDELKPCFWKRLGWSEPSRIIVLDQSDLSD
uniprot
proteins
function
FUNCTION: Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro. {ECO:0000269|PubMed:16549803, ECO:0000269|PubMed:19020301, ECO:0000269|PubMed:20176808, ECO:0000269|PubMed:22405274}.
uniprot
proteins
mass_dalton
162541
uniprot
proteins
mutagenesis
MUTAGEN 431; /note="S->A: Reduced phosphorylation by PLK1 and abolishes depletion from kinetochores and subsequent degradation by the APC/C complex."; /evidence="ECO:0000269|PubMed:22405274"; MUTAGEN 431; /note="S->D,E: Mimicks phosphorylation state; inducing early depletion from kinetochores and subsequent degradation by the APC/C complex."; /evidence="ECO:0000269|PubMed:22405274"; MUTAGEN 791; /note="G->A: Does not affect interaction with CEP55."; /evidence="ECO:0000269|PubMed:20176808"; MUTAGEN 792; /note="P->A: Abolishes interaction with CEP55."; /evidence="ECO:0000269|PubMed:20176808"; MUTAGEN 797; /note="Y->A: Abolishes interaction with CEP55."; /evidence="ECO:0000269|PubMed:20176808"; MUTAGEN 889..897; /note="Missing: Prevents degradation during metaphase."; /evidence="ECO:0000269|PubMed:22405274
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Thr residues by CDK1 during early phases of mitosis, promoting the interaction with PLK1 and recruitment to kinetochores. Phosphorylated on Ser-431 by PLK1 during late prometaphase promotes the rapid depletion from kinetochores and its subsequent degradation by the APC/C complex. {ECO:0000269|PubMed:22405274}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11279525
uniprot
proteins
pubmed
12711554
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16549803
uniprot
proteins
pubmed
17383626
uniprot
proteins
pubmed
19020301
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20176808
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21364893
uniprot
proteins
pubmed
22245112
uniprot
proteins
pubmed
22405274
uniprot
proteins
sequence_length
1450
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Midbody. Chromosome, centromere, kinetochore. Note=Detected in the intercellular bridges that connect male germ cell daughter cells after cell division.
uniprot
proteins