Atg12
entrez
67526
canonical
uniprot
Q9CQY1
canonical
ensembl
ENSMUSG00000032905
resolver
ensp
ENSMUSP00000038489
resolver
enst
ENSMUST00000035648
resolver
genesymbol
Atg12
resolver
genesymbol_syn
Apg12
resolver
genesymbol_syn
Apg12l
resolver
uniprot
Q3TKE5
resolver
uniprot
Q9D7Y5
resolver
uniprot_entry
ATG12_MOUSE
resolver
uniprot_sec
Q3TKE5
resolver
uniprot_sec
Q9D7Y5
resolver
amino_acid_sequence
MSEDSEVVLQLPSAPVGAGGESLPELSPETATPEPPSSAAVSPGTEEPPGDTKKKIDILLKAVGDTPIMKTKKWAVERTRTIQGLIDFIKKFLKLVASEQLFIYVNQSFAPSPDQEVGTLYECFGSDGKLVLHYCKSQAWG
uniprot
proteins
function
FUNCTION: Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. As part of the ATG8 conjugation system with ATG5 and ATG16L1, required for recruitment of LRRK2 to stressed lysosomes and induction of LRRK2 kinase activity in response to lysosomal stress (PubMed:38227290). {ECO:0000269|PubMed:11266458, ECO:0000269|PubMed:12890687, ECO:0000269|PubMed:20723759, ECO:0000269|PubMed:38227290}.; FUNCTION: (Microbial infection) May act as a proviral factor. In association with ATG5, negatively regulates the innate antiviral immune response by impairing the type I IFN production pathway upon vesicular stomatitis virus (VSV) infection. {ECO:0000269|PubMed:17709747}.
uniprot
proteins
mass_dalton
15207
uniprot
proteins
post_translational_modification
PTM: Acetylated by EP300. {ECO:0000250}.
uniprot
proteins
protein_family
ATG12 family
uniprot
proteins
pubmed
11266458
uniprot
proteins
pubmed
12482611
uniprot
proteins
pubmed
12665549
uniprot
proteins
pubmed
12890687
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17709747
uniprot
proteins
pubmed
18704115
uniprot
proteins
pubmed
18768753
uniprot
proteins
pubmed
19417210
uniprot
proteins
pubmed
20723759
uniprot
proteins
pubmed
22082872
uniprot
proteins
pubmed
25686249
uniprot
proteins
pubmed
38227290
uniprot
proteins
sequence_length
141
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Preautophagosomal structure membrane {ECO:0000250|UniProtKB:O94817}; Peripheral membrane protein {ECO:0000250|UniProtKB:O94817}. Note=TECPR1 recruits the ATG12-ATG5 conjugate to the autolysosomal membrane. {ECO:0000250|UniProtKB:O94817}.
uniprot
proteins