Sun1
entrez
77053
canonical
uniprot
Q9D666
canonical
ensembl
ENSMUSG00000036817
resolver
ensp
ENSMUSP00000056655
resolver
ensp
ENSMUSP00000077756
resolver
ensp
ENSMUSP00000098086
resolver
ensp
ENSMUSP00000106506
resolver
ensp
ENSMUSP00000106507
resolver
ensp
ENSMUSP00000106508
resolver
ensp
ENSMUSP00000312893
resolver
ensp
ENSMUSP00000312895
resolver
ensp
ENSMUSP00000312897
resolver
ensp
ENSMUSP00000312899
resolver
ensp
ENSMUSP00000312910
resolver
ensp
ENSMUSP00000312923
resolver
genesymbol
Sun1
resolver
genesymbol_syn
Unc84a
resolver
uniprot
D3Z0V9
resolver
uniprot
Q3TIW3
resolver
uniprot
Q3TV96
resolver
uniprot
Q6B4H0
resolver
uniprot
Q80SU8
resolver
uniprot
Q8BZ99
resolver
uniprot
Q99P23
resolver
uniprot_entry
SUN1_MOUSE
resolver
uniprot_sec
D3Z0V9
resolver
uniprot_sec
Q3TIW3
resolver
uniprot_sec
Q3TV96
resolver
uniprot_sec
Q6B4H0
resolver
uniprot_sec
Q80SU8
resolver
uniprot_sec
Q8BZ99
resolver
uniprot_sec
Q99P23
resolver
amino_acid_sequence
MDFSRLHTYTPPQCVPENTGYTYALSSSYSSDALDFETEHKLEPVFDSPRMSRRSLRLVTTASYSSGDSQAIDSHISTSRATPAKGRETRTVKQRRSASKPAFSINHLSGKGLSSSTSHDSSCSLRSATVLRHPVLDESLIREQTKVDHFWGLDDDGDLKGGNKAATQGNGELAAEVASSNGYTCRDCRMLSARTDALTAHSAIHGTTSRVYSRDRTLKPRGVSFYLDRTLWLAKSTSSSFASFIVQLFQVVLMKLNFETYKLKGYESRAYESQSYETKSHESEAHLGHCGRMTAGELSRVDGESLCDDCKGKKHLEIHTATHSQLPQPHRVAGAMGRLCIYTGDLLVQALRRTRAAGWSVAEAVWSVLWLAVSAPGKAASGTFWWLGSGWYQFVTLISWLNVFLLTRCLRNICKVFVLLLPLLLLLGAGVSLWGQGNFFSLLPVLNWTAMQPTQRVDDSKGMHRPGPLPPSPPPKVDHKASQWPQESDMGQKVASLSAQCHNHDERLAELTVLLQKLQIRVDQVDDGREGLSLWVKNVVGQHLQEMGTIEPPDAKTDFMTFHHDHEVRLSNLEDVLRKLTEKSEAIQKELEETKLKAGSRDEEQPLLDRVQHLELELNLLKSQLSDWQHLKTSCEQAGARIQETVQLMFSEDQQGGSLEWLLEKLSSRFVSKDELQVLLHDLELKLLQNITHHITVTGQAPTSEAIVSAVNQAGISGITEAQAHIIVNNALKLYSQDKTGMVDFALESGGGSILSTRCSETYETKTALLSLFGVPLWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMKIYPTTFTMEHIPKTLSPTGNISSAPKDFAVYGLETEYQEEGQPLGRFTYDQEGDSLQMFHTLERPDQAFQIVELRVLSNWGHPEYTCLYRFRVHGEPIQ
uniprot
proteins
function
FUNCTION: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton (PubMed:16380439, PubMed:20711465, PubMed:24062341, PubMed:25892231, PubMed:26842404). The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning (PubMed:19874786). Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration (PubMed:19874786). Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly (PubMed:17543860, PubMed:19211677, PubMed:19509342, PubMed:24062341, PubMed:25892231, PubMed:26842404). Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis (PubMed:17543860). Helps to define the distribution of nuclear pore complexes (NPCs) (PubMed:17724119). Required for efficient localization of SYNE4 in the nuclear envelope (PubMed:23348741). May be involved in nuclear remodeling during sperm head formation in spermatogenesis (PubMed:20711465). May play a role in DNA repair by suppressing non-homologous end joining repair to facilitate the repair of DNA cross-links (By similarity). {ECO:0000250|UniProtKB:O94901, ECO:0000269|PubMed:16380439, ECO:0000269|PubMed:17543860, ECO:0000269|PubMed:17724119, ECO:0000269|PubMed:19211677, ECO:0000269|PubMed:19509342, ECO:0000269|PubMed:19874786, ECO:0000269|PubMed:20711465, ECO:0000269|PubMed:23348741, ECO:0000269|PubMed:24062341, ECO:0000269|PubMed:25892231, ECO:0000269|PubMed:26842404}.; FUNCTION: Isoform 5 may be involved in nuclear remodeling during sperm head formation in spermatogenesis. A probable SUN1 isoform 5:SYNE3 LINC complex may tether spermatid nuclei to anterior cytoskeletal structures such as actin filaments present at membraneous junctions of spermatids and Sertoli cells. {ECO:0000305|PubMed:20711465}.
uniprot
proteins
mass_dalton
101976
uniprot
proteins
post_translational_modification
PTM: The disulfide bond with KASH domain-containing nesprins is required for stability of the respective LINC complexes under tensile forces. {ECO:0000250|UniProtKB:Q9UH99}.
uniprot
proteins
pubmed
11593002
uniprot
proteins
pubmed
12036294
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16380439
uniprot
proteins
pubmed
16648470
uniprot
proteins
pubmed
17132086
uniprot
proteins
pubmed
17543860
uniprot
proteins
pubmed
17724119
uniprot
proteins
pubmed
18845190
uniprot
proteins
pubmed
19211677
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19509342
uniprot
proteins
pubmed
19841137
uniprot
proteins
pubmed
19843581
uniprot
proteins
pubmed
19874786
uniprot
proteins
pubmed
19933576
uniprot
proteins
pubmed
20711465
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21966565
uniprot
proteins
pubmed
22826121
uniprot
proteins
pubmed
23348741
uniprot
proteins
pubmed
24062341
uniprot
proteins
pubmed
24413433
uniprot
proteins
pubmed
25892231
uniprot
proteins
pubmed
26842404
uniprot
proteins
pubmed
29878215
uniprot
proteins
sequence_length
913
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000269|PubMed:11593002, ECO:0000269|PubMed:12036294, ECO:0000269|PubMed:16380439, ECO:0000269|PubMed:16648470, ECO:0000269|PubMed:17132086, ECO:0000269|PubMed:17724119, ECO:0000269|PubMed:18845190, ECO:0000269|PubMed:19841137, ECO:0000269|PubMed:19843581, ECO:0000269|PubMed:19874786, ECO:0000269|PubMed:23348741}; Single-pass type II membrane protein {ECO:0000269|PubMed:11593002, ECO:0000269|PubMed:12036294, ECO:0000269|PubMed:16380439, ECO:0000269|PubMed:16648470, ECO:0000269|PubMed:17132086, ECO:0000269|PubMed:17724119, ECO:0000269|PubMed:18845190, ECO:0000269|PubMed:19841137, ECO:0000269|PubMed:19843581, ECO:0000269|PubMed:19874786, ECO:0000269|PubMed:23348741}. Note=At oocyte MI stage localized around the spindle, at MII stage localized to the spindle poles. In round spermatids mainly localizes to the posterior pole of the nucleus. This localization is gradually disappearing during spermiogenesis. In elongated spermatids localizes to anterior regions outside the nucleus indicative for isoform 5. {ECO:0000269|PubMed:20711465, ECO:0000269|PubMed:26842404}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasmic vesicle, secretory vesicle, acrosome outer membrane {ECO:0000305|PubMed:20711465}. Note=Localized to the anterior pole of spermatids. {ECO:0000305|PubMed:20711465}.
uniprot
proteins
transmembrane_region
TRANSMEM 416..436; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins