Mrgpra1
entrez
233221
canonical
uniprot
Q91WW5
canonical
ensembl
ENSMUSG00000050650
resolver
ensp
ENSMUSP00000129978
resolver
enst
ENSMUST00000098438
resolver
genesymbol
Mrgpra1
resolver
genesymbol_syn
Mrga1
resolver
uniprot
A0JNS0
resolver
uniprot
G3UW97
resolver
uniprot_entry
G3UW97_MOUSE
resolver
uniprot_entry
MRGA1_MOUSE
resolver
uniprot_sec
A0JNS0
resolver
activity_regulation
ACTIVITY REGULATION: Bilirubin IXalpha facilites activation, probably by acting as a positive allosteric modulator. {ECO:0000269|PubMed:30657454}.
uniprot
proteins
amino_acid_sequence
MDNTIPGGINITILIPNLMIIIFGLVGLTGNGIVFWLLGFCLHRNAFSVYILNLALADFFFLLGHIIDSILLLLNVFYPITFLLCFYTIMMVLYIAGLSMLSAISTERCLSVLCPIWYHCHRPEHTSTVMCAVIWVLSLLICILNSYFCGFLNTQYKNENGCLALNFFTAAYLMFLFVVLCLSSLALVARLFCGTGQIKLTRLYVTIILSILVFLLCGLPFGIHWFLLFKIKDDFHVFDLGFYLASVVLTAINSCANPIIYFFVGSFRHRLKHQTLKMVLQNALQDTPETAKIMVEMSRSKSEP
uniprot
proteins
function
FUNCTION: G protein-coupled receptor activated by a subset of RFamide-family neuropeptides such as FLRF-amide and FMRF-amide (PubMed:12397184). Also acts as a receptor for substance P, a basic secretagogue neuropeptide released from the terminals of specific sensory nerves (PubMed:28219706). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:12397184). Mrgpra1 is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca2+ ions from intracellular stores, respectively (PubMed:12397184). May regulate the function of nociceptive neurons by modulation of pain perception (PubMed:12397184). Does not act as a receptor for bile acids (PubMed:31068464). May be involved in itch perception following activatuion by substance P (PubMed:28219706, PubMed:30657454). {ECO:0000269|PubMed:12397184, ECO:0000269|PubMed:28219706, ECO:0000269|PubMed:30657454, ECO:0000269|PubMed:31068464}.
uniprot
proteins
mass_dalton
34381
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Mas subfamily
uniprot
proteins
pubmed
11551509
uniprot
proteins
pubmed
12397184
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
28219706
uniprot
proteins
pubmed
30657454
uniprot
proteins
pubmed
31068464
uniprot
proteins
sequence_length
304
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11551509}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 18..38; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 54..74; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 76..96; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 132..152; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 167..187; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 207..227; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 244..264; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins