Cnot6
entrez
104625
canonical
uniprot
Q8K3P5
canonical
ensembl
ENSMUSG00000020362
resolver
ensp
ENSMUSP00000020624
resolver
ensp
ENSMUSP00000121239
resolver
ensp
ENSMUSP00000324205
resolver
ensp
ENSMUSP00000324207
resolver
ensp
ENSMUSP00000324209
resolver
ensp
ENSMUSP00000324211
resolver
genesymbol
Cnot6
resolver
genesymbol_syn
Ccr4
resolver
genesymbol_syn
Kiaa1194
resolver
uniprot
Q5NCL3
resolver
uniprot
Q80V15
resolver
uniprot_entry
CNOT6_MOUSE
resolver
uniprot_sec
Q5NCL3
resolver
uniprot_sec
Q80V15
resolver
amino_acid_sequence
MPKEKYEPPDPRRMYTIMSSEEAANGKKSHWAELEISGKVRSLSSSLWSLTHLTALHLSDNSLSCIPSDIAKLHNLVYLDLSHNQIQSLPAELGNMVSLRELHLNYNQLRVLPFELGKLFQLQTLSLKGNPLTQDILNLCLEPDGTRRLLNYLLDNLSGTAKRISTEQPPPRSWIMLQEPDRTRPTALFSVMCYNVLCDKYATRQLYGYCPSWALNWDYRKKAIIQEILSCNADIISLQEVETEQYYSFFLVELKERGYNGFFSPKSRARTMSEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQLAMANSEGSEAMLNRVMTKDNIGVAVLLELRKELIEMSSGKPHLGTEKQLILVANAHMHWDPEYSDVKLVQTMMFLSEVKNIIDKASRSLKSSVLGECGTIPLVLCADLNSLPDSGVVEYLSTGGVETNHKDFKELRYNESLTNFSCNGKNGMTNGRITHGFKLKSAYENGLMPYTNYTFDFKGIIDYIFYSKPQLNTLAILGPLDHHWLVENNISGCPHPLIPSDHFSLFAQLELLLPFLPQVNGIHLPGRR
uniprot
proteins
ec_number
3.1.13.4
uniprot
proteins
function
FUNCTION: Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors. Mediates cell proliferation and cell survival and prevents cellular senescence. {ECO:0000250|UniProtKB:Q9ULM6}.
uniprot
proteins
mass_dalton
63304
uniprot
proteins
protein_family
CCR4/nocturin family
uniprot
proteins
pubmed
11747467
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15314026
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22367759
uniprot
proteins
sequence_length
557
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96LI5}. Nucleus {ECO:0000250|UniProtKB:Q96LI5}. Note=Predominantly cytoplasmic. {ECO:0000250|UniProtKB:Q96LI5}.
uniprot
proteins