Hamp
entrez
84604
canonical
uniprot
Q99MH3
canonical
ensembl
ENSRNOG00000021029
resolver
ensp
ENSRNOP00000028545
resolver
genesymbol
Hamp
resolver
genesymbol_syn
Hepc
resolver
uniprot_entry
HEPC_RAT
resolver
amino_acid_sequence
MALSTRIQAACLLLLLLASLSSGAYLRQQTRQTTALQPWHGAESKTDDSALLMLKRRKRDTNFPICLFCCKCCKNSSCGLCCIT
uniprot
proteins
function
FUNCTION: Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes. {ECO:0000250|UniProtKB:P81172}.; FUNCTION: Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa. {ECO:0000250|UniProtKB:P81172}.
uniprot
proteins
mass_dalton
9286
uniprot
proteins
protein_family
Hepcidin family
uniprot
proteins
pubmed
11113132
uniprot
proteins
sequence_length
84
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins