Mettl18
entrez
304928
canonical
uniprot
Q4KM84
canonical
ensembl
ENSRNOG00000025189
resolver
ensembl
ENSRNOG00055017640
resolver
ensembl
ENSRNOG00060009175
resolver
ensembl
ENSRNOG00065020550
resolver
ensp
ENSRNOP00000003480
resolver
ensp
ENSRNOP00000110677
resolver
ensp
ENSRNOP00055023983
resolver
ensp
ENSRNOP00060012061
resolver
ensp
ENSRNOP00065027938
resolver
enst
ENSRNOT00000003636
resolver
enst
ENSRNOT00000157956
resolver
enst
ENSRNOT00055029851
resolver
enst
ENSRNOT00060015460
resolver
enst
ENSRNOT00065034796
resolver
genesymbol
Mettl18
resolver
uniprot_entry
MET18_RAT
resolver
amino_acid_sequence
MAFQFNFSIEEDLENKLTSLDDGTCVLKSQKGKEDKNQSTELPGLPQDRLWKCSSLGSAASSEDTDSPPSTADRSGVPEACEKQPSLKPAKEHVIPKDCDQVLENKVLEMLPGSQHVSTAVVKTISLKEKFPGENIVSQSFSSHSDLIPGVYEGGLKIWECTFDLMTYFTKAKVKFAGQKVLDLGCGSGLLGITASKGGAREVHFQDYNGLVIDEVTLPNVVANVPLQGDSNGINEPAGKRQRKSEVAQETCKCRLFSGEWAEFCKLVLSEKLFVKYDLILTSETIYNPDYYSTLHETLLRLLSRNGRVLLASKAHYFGVGGGVHLFQKFVEEKGVFETRTLEVIDEGLKRFLMEMTFKCPS
uniprot
proteins
ec_number
2.1.1.85
uniprot
proteins
function
FUNCTION: Protein-L-histidine N-tele-methyltransferase that specifically monomethylates RPL3, thereby regulating translation elongation. Histidine methylation of RPL3 regulates translation elongation by slowing ribosome traversal on tyrosine codons: slower elongation provides enough time for proper folding of synthesized proteins and prevents cellular aggregation of tyrosine-rich proteins. {ECO:0000250|UniProtKB:O95568}.
uniprot
proteins
mass_dalton
40009
uniprot
proteins
post_translational_modification
PTM: Monomethylated at His-144 through automethylation. Automethylation at His-144 positively regulates the methyltransferase activity toward RPL3. Probably methylated on other residues. {ECO:0000250|UniProtKB:O95568}.
uniprot
proteins
protein_family
METTL18 family
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
362
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O95568}. Nucleus {ECO:0000250|UniProtKB:O95568}. Nucleus, nucleolus {ECO:0000250|UniProtKB:O95568}.
uniprot
proteins