NUP62
entrez
23636
canonical
uniprot
P37198
canonical
ensembl
ENSG00000213024
resolver
ensp
ENSP00000305503
resolver
ensp
ENSP00000407331
resolver
ensp
ENSP00000468839
resolver
ensp
ENSP00000468842
resolver
ensp
ENSP00000468884
resolver
ensp
ENSP00000471191
resolver
ensp
ENSP00000473192
resolver
ensp
ENSP00000515006
resolver
ensp
ENSP00000515007
resolver
ensp
ENSP00000515008
resolver
ensp
ENSP00000515009
resolver
ensp
ENSP00000515010
resolver
ensp
ENSP00000515011
resolver
ensp
ENSP00000515012
resolver
ensp
ENSP00000515013
resolver
ensp
ENSP00000515014
resolver
ensp
ENSP00000528044
resolver
ensp
ENSP00000528045
resolver
ensp
ENSP00000528046
resolver
ensp
ENSP00000528047
resolver
ensp
ENSP00000528048
resolver
ensp
ENSP00000528049
resolver
ensp
ENSP00000528050
resolver
ensp
ENSP00000528051
resolver
ensp
ENSP00000528052
resolver
ensp
ENSP00000528053
resolver
ensp
ENSP00000610455
resolver
ensp
ENSP00000610456
resolver
ensp
ENSP00000610457
resolver
ensp
ENSP00000610458
resolver
ensp
ENSP00000610459
resolver
ensp
ENSP00000610460
resolver
ensp
ENSP00000610461
resolver
ensp
ENSP00000610462
resolver
ensp
ENSP00000610463
resolver
ensp
ENSP00000610464
resolver
ensp
ENSP00000610465
resolver
ensp
ENSP00000610466
resolver
ensp
ENSP00000620790
resolver
ensp
ENSP00000620791
resolver
ensp
ENSP00000620792
resolver
ensp
ENSP00000620793
resolver
ensp
ENSP00000620794
resolver
ensp
ENSP00000620795
resolver
ensp
ENSP00000620796
resolver
ensp
ENSP00000620797
resolver
ensp
ENSP00000620798
resolver
ensp
ENSP00000620799
resolver
ensp
ENSP00000620800
resolver
ensp
ENSP00000620801
resolver
ensp
ENSP00000620802
resolver
ensp
ENSP00000620803
resolver
ensp
ENSP00000620804
resolver
ensp
ENSP00000620805
resolver
ensp
ENSP00000620806
resolver
ensp
ENSP00000620807
resolver
ensp
ENSP00000620808
resolver
ensp
ENSP00000620809
resolver
ensp
ENSP00000620810
resolver
ensp
ENSP00000620811
resolver
enst
ENST00000352066
resolver
enst
ENST00000422090
resolver
enst
ENST00000596217
resolver
enst
ENST00000596437
resolver
enst
ENST00000597029
resolver
enst
ENST00000598301
resolver
enst
ENST00000599560
resolver
enst
ENST00000599788
resolver
enst
ENST00000600583
resolver
enst
ENST00000600935
resolver
enst
ENST00000700473
resolver
enst
ENST00000700474
resolver
enst
ENST00000700475
resolver
enst
ENST00000700476
resolver
enst
ENST00000700477
resolver
enst
ENST00000700478
resolver
enst
ENST00000857985
resolver
enst
ENST00000857986
resolver
enst
ENST00000857987
resolver
enst
ENST00000857988
resolver
enst
ENST00000857989
resolver
enst
ENST00000857990
resolver
enst
ENST00000857991
resolver
enst
ENST00000857992
resolver
enst
ENST00000857993
resolver
enst
ENST00000857994
resolver
enst
ENST00000940396
resolver
enst
ENST00000940397
resolver
enst
ENST00000940398
resolver
enst
ENST00000940399
resolver
enst
ENST00000940400
resolver
enst
ENST00000940401
resolver
enst
ENST00000940402
resolver
enst
ENST00000940403
resolver
enst
ENST00000940404
resolver
enst
ENST00000940405
resolver
enst
ENST00000940406
resolver
enst
ENST00000940407
resolver
enst
ENST00000950731
resolver
enst
ENST00000950732
resolver
enst
ENST00000950733
resolver
enst
ENST00000950734
resolver
enst
ENST00000950735
resolver
enst
ENST00000950736
resolver
enst
ENST00000950737
resolver
enst
ENST00000950738
resolver
enst
ENST00000950739
resolver
enst
ENST00000950740
resolver
enst
ENST00000950741
resolver
enst
ENST00000950742
resolver
enst
ENST00000950743
resolver
enst
ENST00000950744
resolver
enst
ENST00000950745
resolver
enst
ENST00000950746
resolver
enst
ENST00000950747
resolver
enst
ENST00000950748
resolver
enst
ENST00000950749
resolver
enst
ENST00000950750
resolver
enst
ENST00000950751
resolver
enst
ENST00000950752
resolver
genesymbol
NUP62
resolver
hgnc
HGNC:8066
resolver
uniprot
B3KWU5
resolver
uniprot
Q503A4
resolver
uniprot
Q6GTM2
resolver
uniprot
Q96C43
resolver
uniprot
Q9NSL1
resolver
uniprot_entry
NUP62_HUMAN
resolver
uniprot_sec
B3KWU5
resolver
uniprot_sec
Q503A4
resolver
uniprot_sec
Q6GTM2
resolver
uniprot_sec
Q96C43
resolver
uniprot_sec
Q9NSL1
resolver
amino_acid_sequence
MSGFNFGGTGAPTGGFTFGTAKTATTTPATGFSFSTSGTGGFNFGAPFQPATSTPSTGLFSLATQTPATQTTGFTFGTATLASGGTGFSLGIGASKLNLSNTAATPAMANPSGFGLGSSNLTNAISSTVTSSQGTAPTGFVFGPSTTSVAPATTSGGFSFTGGSTAQPSGFNIGSAGNSAQPTAPATLPFTPATPAATTAGATQPAAPTPTATITSTGPSLFASIATAPTSSATTGLSLCTPVTTAGAPTAGTQGFSLKAPGAASGTSTTTSTAATATATTTSSSSTTGFALNLKPLAPAGIPSNTAAAVTAPPGPGAAAGAAASSAMTYAQLESLINKWSLELEDQERHFLQQATQVNAWDRTLIENGEKITSLHREVEKVKLDQKRLDQELDFILSQQKELEDLLSPLEELVKEQSGTIYLQHADEEREKTYKLAENIDAQLKRMAQDLKDIIEHLNTSGAPADTSDPLQQICKILNAHMDSLQWIDQNSALLQRKVEEVTKVCEGRRKEQERSFRITFD
uniprot
proteins
disease_involvement
DISEASE: Infantile striatonigral degeneration (SNDI) [MIM:271930]: Neurological disorder characterized by symmetrical degeneration of the caudate nucleus, putamen, and occasionally the globus pallidus, with little involvement of the rest of the brain. The clinical features include developmental regression, choreoathetosis, dystonia, spasticity, dysphagia, failure to thrive, nystagmus, optic atrophy, and intellectual disability. {ECO:0000269|PubMed:16786527}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Essential component of the nuclear pore complex (PubMed:1915414). The N-terminal is probably involved in nucleocytoplasmic transport (PubMed:1915414). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex (PubMed:1915414, PubMed:24107630). Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation (PubMed:24107630). It might be involved in protein recruitment to the centrosome after nuclear breakdown (PubMed:24107630). {ECO:0000269|PubMed:1915414, ECO:0000269|PubMed:24107630}.
uniprot
proteins
mass_dalton
53255
uniprot
proteins
post_translational_modification
PTM: O-glycosylated. Contains about 10 N-acetylglucosamine side chain sites predicted for the entire protein, among which only one in the C-terminal. {ECO:0000305}.; PTM: The inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC. {ECO:0000250}.
uniprot
proteins
protein_family
Nucleoporin NSP1/NUP62 family
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16786527
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18266911
uniprot
proteins
pubmed
1915414
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21698267
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22541429
uniprot
proteins
pubmed
22623767
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23652018
uniprot
proteins
pubmed
24107630
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
30543681
uniprot
proteins
sequence_length
522
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000269|PubMed:1915414}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:24107630}. Nucleus envelope {ECO:0000269|PubMed:24107630}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14654843, ECO:0000269|PubMed:24107630}. Note=Central region of the nuclear pore, within the transporter (PubMed:1915414). During mitotic cell division, it associates with the poles of the mitotic spindle (PubMed:24107630). {ECO:0000269|PubMed:1915414, ECO:0000269|PubMed:24107630}.
uniprot
proteins