Slc30a2
entrez
25362
canonical
uniprot
Q62941
canonical
ensembl
ENSRNOG00000054142
resolver
ensp
ENSRNOP00000072908
resolver
enst
ENSRNOT00000082245
resolver
genesymbol
Slc30a2
resolver
genesymbol_syn
Znt2
resolver
uniprot
A0A0G2K450
resolver
uniprot
B4F7D8
resolver
uniprot
Q6P6V5
resolver
uniprot_entry
A0A0G2K450_RAT
resolver
uniprot_entry
B4F7D8_RAT
resolver
uniprot_entry
Q6P6V5_RAT
resolver
uniprot_entry
ZNT2_RAT
resolver
amino_acid_sequence
MASRSFFGALWKSEASRIPPVNLPSVELAVQSNHYCHAQKDSGSHPNSEKQRARRKLYVASAICLVFMIGEIIGGYLAQSLAIMTDAAHLLTDFASMLISLFSLWVSSRPATKTMNFGWQRAEILGALLSVLSIWVVTGVLVYLAVQRLISGDYEIKGDTMLITSGCAVAVNIIMGLALHQSGHGHSHGHSHEDSSQQQQNPSVRAAFIHVVGDLLQSVGVLVAAYIIYFKPEYKYVDPICTFLFSILVLGTTLTILRDVILVLMEGTPKGVDFTTVKNLLLSVDGVEALHSLHIWALTVAQPVLSVHIAIAQNVDAQAVLKVARDRLQGKFNFHTMTIQIESYSEDMKSCQECQGPSE
uniprot
proteins
function
FUNCTION: Electroneutral proton-coupled antiporter concentrating zinc ions into a variety of intracellular organelles including endosomes, zymogen granules and mitochondria. Thereby, plays a crucial role in cellular zinc homeostasis to confer upon cells protection against its potential cytotoxicity (PubMed:20133611, PubMed:8617223). Regulates the zinc concentration of milk, through the transport of zinc ions into secretory vesicles of mammary cells (By similarity). By concentrating zinc ions into lysosomes participates to lysosomal-mediated cell death during early mammary gland involution (By similarity). {ECO:0000250|UniProtKB:Q9BRI3, ECO:0000269|PubMed:20133611, ECO:0000269|PubMed:8617223}.
uniprot
proteins
mass_dalton
39277
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-283. Phosphorylation at Ser-283 prevents localization to lysosomes. Dephosphorylation of Ser-283 which triggers localization to lysosomes, accumulation of zinc into lysosomes and lysosomal-mediated cell death is induced by TNF. {ECO:0000250|UniProtKB:Q9BRI3}.
uniprot
proteins
protein_family
Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
uniprot
proteins
protein_family
SLC30A subfamily
uniprot
proteins
pubmed
20133611
uniprot
proteins
pubmed
8617223
uniprot
proteins
sequence_length
359
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305|PubMed:8617223}; Multi-pass membrane protein {ECO:0000255}. Zymogen granule membrane {ECO:0000305|PubMed:20133611, ECO:0000305|PubMed:8617223}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000305|PubMed:8617223}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000305|PubMed:8617223}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9BRI3}; Multi-pass membrane protein {ECO:0000255}. Note=Localization to lysosomes is induced by TNF. {ECO:0000250|UniProtKB:Q9BRI3}.
uniprot
proteins
transmembrane_region
TRANSMEM 57..77; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 87..107; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 124..144; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 160..180; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 208..228; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 237..257; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 292..312; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins