Gpr143
entrez
18241
canonical
uniprot
P70259
canonical
ensembl
ENSMUSG00000025333
resolver
ensp
ENSMUSP00000026383
resolver
enst
ENSMUST00000026383
resolver
genesymbol
Gpr143
resolver
genesymbol_syn
Oa1
resolver
uniprot
O89031
resolver
uniprot
Q549B6
resolver
uniprot_entry
GP143_MOUSE
resolver
uniprot_entry
Q549B6_MOUSE
resolver
uniprot_sec
O89031
resolver
amino_acid_sequence
MASPRLGIFCCPTWDAATQLVLSFQPRVFHALCLGSGTLRLVLGLLQLLSGRRSVGHRAPATSPAASVHILRAATACDLLGCLGIVIRSTVWIAYPEFIENISNVNATDIWPATFCVGSAMWIQLLYSACFWWLFCYAVDVYLVIRRSAGRSTILLYHIMAWGLAVLLCVEGAVMLYYPSVSRCERGLDHAIPHYVTTYLPLLLVLVANPILFHKTVTSVASLLKGRKGVYTENERLMGAVIKTRFFKIMLVLIACWLSNIINESLLFYLEMQPDIHGGSLKRIQNAARTTWFIMGILNPAQGLLLSLAFYGWTGCSLDVHPPKMVIQWETMTASAAEGTYQTPVRSCVPHQNPRKVVCVGGHTSDEVLSILSEDSDASTVEIHTATGSCNIKEVDSISQAQGEL
uniprot
proteins
function
FUNCTION: Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Also plays a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport. {ECO:0000269|PubMed:18697795}.
uniprot
proteins
mass_dalton
44564
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250}.; PTM: Phosphorylated. {ECO:0000250}.
uniprot
proteins
protein_family
G protein-coupled receptor OA family
uniprot
proteins
pubmed
18697795
uniprot
proteins
pubmed
8889556
uniprot
proteins
pubmed
8921399
uniprot
proteins
sequence_length
405
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Melanosome membrane {ECO:0000250|UniProtKB:P51810}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:P51810}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:P51810}; Multi-pass membrane protein {ECO:0000255}. Note=Distributed throughout the endo-melanosomal system but most of endogenous protein is localized in unpigmented stage II melanosomes. Its expression on the apical cell membrane is sensitive to tyrosine. {ECO:0000250|UniProtKB:P51810}.
uniprot
proteins
transmembrane_region
TRANSMEM 28..48; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 79..99; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 125..145; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 154..174; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 192..212; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 249..269; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 293..313; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins