P55043
uniprot
P55043
canonical
amino_acid_sequence
MTLNGGSGAGGSRSAGRERDRRRGSTPWGPAPPLHRRSMPVDERDLQAALTPGSLAATAAGTRTQGQRLDWPEGSSDSLSSGDSGSEDGVYKVHAAGAPGVGKSALARIFGGVEDGPEAEAAGHTYDRSITVDGEEASLMVYDIWEQDGGCWLPGHCMAMGDAYVIVYSITDKGSFEKASELRVQLRARRQTDVPIILVGNKSDLVRSREVSVDEGRACAEVFDCKFIETSAALHHNVQALFEGVVRQIRLRRDSKEDNARRQAGTRRRESLGKKAKLFLGRIVARNSRKMAFLAKSKSCHDLSVL
uniprot
proteins
function
FUNCTION: May regulate basal voltage-dependent L-type Ca(2+) currents and be required for beta-adrenergic augmentation of Ca(2+) influx in cardiomyocytes, thereby regulating increases in heart rate and contractile force. May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-dependent L-type Ca(2+) currents. Regulates voltage-gated L-type calcium channel subunit alpha-1C trafficking to the cell membrane. Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway (By similarity). Inhibits phosphorylation and activation of CAMK2D (By similarity). {ECO:0000250|UniProtKB:O88667, ECO:0000250|UniProtKB:P55042}.
uniprot
proteins
mass_dalton
33038
uniprot
proteins
protein_family
RGK family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
sequence_length
306
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}.
uniprot
proteins