CNTFR
entrez
1271
canonical
uniprot
P26992
canonical
ensembl
ENSG00000122756
resolver
ensp
ENSP00000242338
resolver
ensp
ENSP00000368265
resolver
ensp
ENSP00000480451
resolver
ensp
ENSP00000538749
resolver
ensp
ENSP00000538750
resolver
ensp
ENSP00000538751
resolver
ensp
ENSP00000538752
resolver
ensp
ENSP00000538753
resolver
ensp
ENSP00000538754
resolver
ensp
ENSP00000538755
resolver
ensp
ENSP00000538756
resolver
ensp
ENSP00000538757
resolver
ensp
ENSP00000538759
resolver
ensp
ENSP00000538761
resolver
ensp
ENSP00000538762
resolver
ensp
ENSP00000538763
resolver
ensp
ENSP00000538764
resolver
ensp
ENSP00000538767
resolver
ensp
ENSP00000538768
resolver
ensp
ENSP00000538770
resolver
ensp
ENSP00000538771
resolver
ensp
ENSP00000538772
resolver
ensp
ENSP00000538773
resolver
ensp
ENSP00000538774
resolver
ensp
ENSP00000538775
resolver
ensp
ENSP00000593868
resolver
ensp
ENSP00000593869
resolver
ensp
ENSP00000593870
resolver
ensp
ENSP00000593871
resolver
ensp
ENSP00000593872
resolver
ensp
ENSP00000593873
resolver
ensp
ENSP00000620072
resolver
ensp
ENSP00000620074
resolver
ensp
ENSP00000620075
resolver
ensp
ENSP00000620077
resolver
ensp
ENSP00000620078
resolver
ensp
ENSP00000620079
resolver
ensp
ENSP00000620080
resolver
ensp
ENSP00000620081
resolver
ensp
ENSP00000620082
resolver
ensp
ENSP00000620083
resolver
ensp
ENSP00000620085
resolver
ensp
ENSP00000620087
resolver
ensp
ENSP00000620088
resolver
ensp
ENSP00000620089
resolver
ensp
ENSP00000651231
resolver
enst
ENST00000351266
resolver
enst
ENST00000378980
resolver
enst
ENST00000610543
resolver
enst
ENST00000868690
resolver
enst
ENST00000868691
resolver
enst
ENST00000868692
resolver
enst
ENST00000868693
resolver
enst
ENST00000868694
resolver
enst
ENST00000868695
resolver
enst
ENST00000868696
resolver
enst
ENST00000868697
resolver
enst
ENST00000868698
resolver
enst
ENST00000868700
resolver
enst
ENST00000868702
resolver
enst
ENST00000868703
resolver
enst
ENST00000868704
resolver
enst
ENST00000868705
resolver
enst
ENST00000868708
resolver
enst
ENST00000868709
resolver
enst
ENST00000868711
resolver
enst
ENST00000868712
resolver
enst
ENST00000868713
resolver
enst
ENST00000868714
resolver
enst
ENST00000868715
resolver
enst
ENST00000868716
resolver
enst
ENST00000923809
resolver
enst
ENST00000923810
resolver
enst
ENST00000923811
resolver
enst
ENST00000923812
resolver
enst
ENST00000923813
resolver
enst
ENST00000923814
resolver
enst
ENST00000950013
resolver
enst
ENST00000950015
resolver
enst
ENST00000950016
resolver
enst
ENST00000950018
resolver
enst
ENST00000950019
resolver
enst
ENST00000950020
resolver
enst
ENST00000950021
resolver
enst
ENST00000950022
resolver
enst
ENST00000950023
resolver
enst
ENST00000950024
resolver
enst
ENST00000950026
resolver
enst
ENST00000950028
resolver
enst
ENST00000950029
resolver
enst
ENST00000950030
resolver
genesymbol
CNTFR
resolver
hgnc
HGNC:2170
resolver
uniprot
Q5U050
resolver
uniprot_entry
CNTFR_HUMAN
resolver
uniprot_sec
Q5U050
resolver
amino_acid_sequence
MAAPVPWACCAVLAAAAAVVYAQRHSPQEAPHVQYERLGSDVTLPCGTANWDAAVTWRVNGTDLAPDLLNGSQLVLHGLELGHSGLYACFHRDSWHLRHQVLLHVGLPPREPVLSCRSNTYPKGFYCSWHLPTPTYIPNTFNVTVLHGSKIMVCEKDPALKNRCHIRYMHLFSTIKYKVSISVSNALGHNATAITFDEFTIVKPDPPENVVARPVPSNPRRLEVTWQTPSTWPDPESFPLKFFLRYRPLILDQWQHVELSDGTAHTITDAYAGKEYIIQVAAKDNEIGTWSDWSVAAHATPWTEEPRHLTTEAQAAETTTSTTSSLAPPPTTKICDPGELGSGGGPSAPFLVSVPITLALAAAAATASSLLI
uniprot
proteins
function
FUNCTION: Functions either as a membrane-anchored non-signaling receptor via a GPI anchor or, after proteolytic release, as a soluble ligand-binding chaperone, and mediates signaling of CNTF-related cytokines, including ciliary neurotrophic factor (CNTF), cardiotrophin-like cytokine factor 1 (CLCF1), and the heterodimeric cytokine formed by CLCF1 and the cytokine receptor-like factor 1 (CRLF1) (PubMed:10966616, PubMed:11285233, PubMed:11294841, PubMed:26858303, PubMed:31932351, PubMed:36930708, PubMed:7681218). Involved namely in cell survival of motor neurons and regulation of oligodendrocyte progenitor proliferation (PubMed:11285233, PubMed:19386761, PubMed:31932351). Functions within the ciliary neurotrophic factor receptor (CNTFR) complex as a membrane-anchored non-signaling receptor subunit associated with two other signaling receptor subunits IL6ST/gp130 and LIFR (PubMed:10966616, PubMed:11285233, PubMed:11294841, PubMed:26858303, PubMed:31932351, PubMed:36930708, PubMed:7681218). Also, functions within the humanin receptor complex as a membrane-anchored non-signaling receptor subunit associated with IL6ST/GP130 and IL27RA/WSX1 that mediates the MT-RNR2/humanin signaling which induces neuroprotection (PubMed:19386761). Alternatively functions as a soluble ligand-binding chaperone that binds ligand in the extracellular space, forming a cytokine complex which is delivered to the IL6ST/gp130 and LIFR signaling receptor subunits (PubMed:11285233, PubMed:31932351, PubMed:7681218). Mechanistically, ligand binding to the CNTFR induces dimerization of the IL6ST/gp130 and LIFR (or IL27RA/WSX1 in the case of MT-RNR2/humanin), which activate JAK tyrosine kinases (JAK1 or JAK2 and to lesser extent TYK2) bound to their intracellular domains (PubMed:10966616, PubMed:11285233, PubMed:11294841, PubMed:19386761, PubMed:7681218). These kinases subsequently phosphorylate IL6ST/gp130 and LIFR (or IL27RA/WSX1) (PubMed:10966616, PubMed:11285233, PubMed:11294841, PubMed:7681218). The tyrosine phosphorylated signaling receptors serve in turn as docking sites for recruitment and activation of signal transducer and activators of transcription (STAT3 and to lesser extent STAT1) (PubMed:10966616, PubMed:11285233, PubMed:11294841, PubMed:19386761, PubMed:7681218). {ECO:0000269|PubMed:10966616, ECO:0000269|PubMed:11285233, ECO:0000269|PubMed:11294841, ECO:0000269|PubMed:19386761, ECO:0000269|PubMed:26858303, ECO:0000269|PubMed:31932351, ECO:0000269|PubMed:36930708, ECO:0000269|PubMed:7681218}.
uniprot
proteins
mass_dalton
40633
uniprot
proteins
post_translational_modification
PTM: GPI processing by GDPD2 releases 2 soluble forms, a 100 kDa form and a 90 kDa form (PubMed:31932351). In vitro, GPI processing is also mediated by a phosphatidylinositol (PI) phospholipase C (PI-PLC) releasing a soluble form of 90 kDa (PubMed:1648265, PubMed:31932351). The 100 kDa form is released by extracellular vesicles (PubMed:31932351). {ECO:0000269|PubMed:1648265, ECO:0000269|PubMed:31932351}.
uniprot
proteins
protein_family
Type 3 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
10966616
uniprot
proteins
pubmed
11285233
uniprot
proteins
pubmed
11294841
uniprot
proteins
pubmed
12707266
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1648265
uniprot
proteins
pubmed
19386761
uniprot
proteins
pubmed
26858303
uniprot
proteins
pubmed
31932351
uniprot
proteins
pubmed
36930708
uniprot
proteins
pubmed
7681218
uniprot
proteins
pubmed
7774913
uniprot
proteins
sequence_length
372
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1648265, ECO:0000269|PubMed:31932351}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:1648265, ECO:0000269|PubMed:31932351}. Secreted {ECO:0000269|PubMed:1648265, ECO:0000269|PubMed:31932351, ECO:0000269|PubMed:7681218}. Note=Localized at cell membrane when associated with SORL1 (PubMed:26858303). Released from plasma membrane and extracellular vesicles (EV) by GDPD2 (PubMed:31932351). {ECO:0000269|PubMed:26858303, ECO:0000269|PubMed:31932351}.
uniprot
proteins