PPP2R3C
entrez
55012
canonical
uniprot
Q969Q6
canonical
ensembl
ENSG00000092020
resolver
ensp
ENSP00000261475
resolver
ensp
ENSP00000598367
resolver
ensp
ENSP00000677995
resolver
genesymbol
PPP2R3C
resolver
genesymbol_syn
C14orf10
resolver
genesymbol_syn
G5PR
resolver
hgnc
HGNC:17485
resolver
uniprot
B4DEN7
resolver
uniprot
D3DS97
resolver
uniprot
D3DS98
resolver
uniprot
Q5GJ55
resolver
uniprot
Q5GJ56
resolver
uniprot
Q6P4G2
resolver
uniprot
Q86TZ3
resolver
uniprot
Q9NWR9
resolver
uniprot_entry
P2R3C_HUMAN
resolver
uniprot_sec
B4DEN7
resolver
uniprot_sec
D3DS97
resolver
uniprot_sec
D3DS98
resolver
uniprot_sec
Q5GJ55
resolver
uniprot_sec
Q5GJ56
resolver
uniprot_sec
Q6P4G2
resolver
uniprot_sec
Q86TZ3
resolver
uniprot_sec
Q9NWR9
resolver
amino_acid_sequence
MDWKEVLRRRLATPNTCPNKKKSEQELKDEEMDLFTKYYSEWKGGRKNTNEFYKTIPRFYYRLPAEDEVLLQKLREESRAVFLQRKSRELLDNEELQNLWFLLDKHQTPPMIGEEAMINYENFLKVGEKAGAKCKQFFTAKVFAKLLHTDSYGRISIMQFFNYVMRKVWLHQTRIGLSLYDVAGQGYLRESDLENYILELIPTLPQLDGLEKSFYSFYVCTAVRKFFFFLDPLRTGKIKIQDILACSFLDDLLELRDEELSKESQETNWFSAPSALRVYGQYLNLDKDHNGMLSKEELSRYGTATMTNVFLDRVFQECLTYDGEMDYKTYLDFVLALENRKEPAALQYIFKLLDIENKGYLNVFSLNYFFRAIQELMKIHGQDPVSFQDVKDEIFDMVKPKDPLKISLQDLINSNQGDTVTTILIDLNGFWTYENREALVANDSENSADLDDT
uniprot
proteins
disease_involvement
DISEASE: Myoectodermal gonadal dysgenesis syndrome (MEGD) [MIM:618419]: An autosomal recessive disorder characterized by 46,XY complete gonadal dysgenesis and extragonadal anomalies, including typical facial gestalt, low birth weight, myopathy, rod and cone dystrophy, anal atresia, omphalocele, sensorineural hearing loss, dry and scaly skin, skeletal abnormalities, renal agenesis and neuromotor delay. {ECO:0000269|PubMed:30893644}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Spermatogenic failure 36 (SPGF36) [MIM:618420]: An autosomal dominant infertility disorder due to teratozoospermia, with spermatozoa showing anomalies of the head, acrosome, and nucleus. {ECO:0000269|PubMed:30893644}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: May regulate MCM3AP phosphorylation through phosphatase recruitment (By similarity). May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex (PubMed:24333728). May play a role in the activation-induced cell death of B-cells (By similarity). {ECO:0000250|UniProtKB:Q9JK24, ECO:0000269|PubMed:24333728}.
uniprot
proteins
mass_dalton
53316
uniprot
proteins
pubmed
12167160
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15820313
uniprot
proteins
pubmed
24333728
uniprot
proteins
pubmed
30893644
uniprot
proteins
sequence_length
453
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15820313}. Cytoplasm {ECO:0000269|PubMed:15820313}. Note=Excluded from the nucleoli. Localization is cell cycle-dependent. Localizes to the cytoplasm during cytokinesis. {ECO:0000269|PubMed:15820313}.
uniprot
proteins