Ralgds
entrez
19730
canonical
uniprot
Q03385
canonical
ensembl
ENSMUSG00000026821
resolver
ensp
ENSMUSP00000028170
resolver
ensp
ENSMUSP00000097812
resolver
ensp
ENSMUSP00000109526
resolver
ensp
ENSMUSP00000248636
resolver
ensp
ENSMUSP00000248639
resolver
ensp
ENSMUSP00000248640
resolver
ensp
ENSMUSP00000248642
resolver
ensp
ENSMUSP00000248688
resolver
enst
ENSMUST00000028170
resolver
enst
ENSMUST00000100241
resolver
enst
ENSMUST00000113893
resolver
genesymbol
Ralgds
resolver
genesymbol_syn
Rgds
resolver
genesymbol_syn
mKIAA1308
resolver
uniprot
A2AK33
resolver
uniprot
F6ZAZ0
resolver
uniprot
Q3TWC1
resolver
uniprot
Q3TXZ3
resolver
uniprot
Q3UQY9
resolver
uniprot
Q6ZPU1
resolver
uniprot
Q8R077
resolver
uniprot_entry
A2AK33_MOUSE
resolver
uniprot_entry
F6ZAZ0_MOUSE
resolver
uniprot_entry
GNDS_MOUSE
resolver
uniprot_entry
Q3TWC1_MOUSE
resolver
uniprot_entry
Q3TXZ3_MOUSE
resolver
uniprot_entry
Q3UQY9_MOUSE
resolver
uniprot_entry
Q6ZPU1_MOUSE
resolver
uniprot_sec
Q8R077
resolver
amino_acid_sequence
MMVDCQSSTQEIGEELINGVIYSISLRKVQLHQGATKGQRWLGCENESALNLYETCKVRTVKAGTLEKLVEHLVPAFQGSDLSYVTVFLCTYRAFTTTQQVLDLLFKRYGRCDALTASSRYGCILPYSSEDGGPQDQLKNAISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDLERRAHLLLAQLEDLEPSEAESEALSPAPVLSLKPASQLEPALLLTPSQVVTSTPVREPAAAPVPVLASSPVVAPAPELEPVPEPPQEPEPSLALAPELEPAVSQSLELESAPVPTPALEPSWSLPEATENGLTEKPHLLLFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVAQFNNVANCVITTCLGDQSMKAPDRARVVEHWIEVARECRALKNFSSLYAILSALQSNAIHRLKKTWEEVSRDSFRVFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMNPRRAQRRQKETGVIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPEEHFGTWFRAMERLSEAESYTLSCELEPPSESASNTLRSKKSTAIVKRWSDRQAPSTELSTSSSAHSKSCDQLRCSPYLGSGDITDALSVHSAGSSSSDVEEINMSFVPESPDGQEKKFWESASQSSPETSGISSASSSTSSSSASTTPVSTTRTHKRSVSGVCSYSSSLPLYNQQVGDCCIIRVSLDVDNGNMYKSILVTSQDKAPTVIRKAMDKHNLDEDEPEDYELVQIISEDHKLKIPENANVFYAMNSTANYDFILKKRTFTKGAKVKHGASSTLPRMKQKGLRIAKGIF
uniprot
proteins
function
FUNCTION: Functions as a guanine nucleotide exchange factor (GEF) activating either RalA or RalB GTPases and plays an important role in intracellular transport. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap (PubMed:27773821). During bacterial clearance, recognizes 'Lys-33'-linked polyubiquitinated TRAF3 and subsequently mediates assembly of the exocyst complex (By similarity). {ECO:0000250|UniProtKB:Q12967, ECO:0000269|PubMed:27773821}.
uniprot
proteins
mass_dalton
94202
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Tyr-752 by MET blocks HRAS binding. {ECO:0000269|PubMed:27773821}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16580637
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27773821
uniprot
proteins
pubmed
8094051
uniprot
proteins
sequence_length
852
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16580637}. Nucleus {ECO:0000269|PubMed:16580637}. Note=Localizes mainly in the peripheral region of the cytoplasmic membrane in oocytes and in preimplantation embryos until the 8-cell stage. Between the late 1-cell and the early 2-cell stages, nuclear localization becomes stronger. After the 4-cell stage, not detected in the nucleus. {ECO:0000269|PubMed:16580637}.
uniprot
proteins