Marchf5
entrez
69104
canonical
uniprot
Q3KNM2
canonical
ensembl
ENSMUSG00000023307
resolver
ensp
ENSMUSP00000024078
resolver
ensp
ENSMUSP00000108010
resolver
ensp
ENSMUSP00000312125
resolver
ensp
ENSMUSP00000349844
resolver
enst
ENSMUST00000024078
resolver
enst
ENSMUST00000112391
resolver
genesymbol
Marchf5
resolver
genesymbol_syn
March5
resolver
uniprot
A0A0R4J1H0
resolver
uniprot
A2RTC8
resolver
uniprot
Q3KNM3
resolver
uniprot
Q6P230
resolver
uniprot
Q9CPS3
resolver
uniprot
Q9CTI6
resolver
uniprot_entry
A0A0R4J1H0_MOUSE
resolver
uniprot_entry
A2RTC8_MOUSE
resolver
uniprot_entry
MARH5_MOUSE
resolver
uniprot_sec
Q3KNM3
resolver
uniprot_sec
Q6P230
resolver
uniprot_sec
Q9CPS3
resolver
uniprot_sec
Q9CTI6
resolver
amino_acid_sequence
MPDQALQQMLDRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVHQACLQRWVDEKQRGNSTARVACPQCNAEYLIVFPKLGPVVYVLDLADRLISKACPFAAAGIMVGSIYWTAVTYGAVTVMQVVGHKEGLDVMERADPLFLLIGLPTIPVMLILGKMIRWEDYVLRLWRKYSNKLQILNSIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTIATIVGKLMFSSVNSNLQRTILGGIAFVAIKGAFKVYFKQQQYLRQAHRKILNYPEQEEA
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission and as an important regulator of immune response. Plays a crucial role in maintaining mitochondrial homeostasis by regulating the dynamics of mitochondria through the ubiquitination of key proteins involved in fission and fusion such as FIS1, DNM1L and MFN1 (By similarity). Acts as a critical determinant of mitotic apoptosis through both MCL1-dependent and -independent pathways (PubMed:36329234). Turns off persistent immune signaling by degrading oligomeric complexes of retinoic acid-inducible gene I/DDX58 and mitochondrial antiviral-signaling protein/MAVS formed upon RNA virus infection. Promotes STING-mediated type-I interferon production via 'Lys-63'-linked ubiquitination of STING1 thereby preserving its activity and preventing the formation of inactive STING1 polymers. Plays also an essential role in the formation of PEX3-containing vesicles in the de novo biogenesis of peroxisomes from mitochondria. Acts as a regulator of NLRP3 inflammasome activation on the mitochondria by mediating the 'Lys-27'-linked polyubiquitination of NLRP3, positively regulating the NLRP3-NEK7 complex formation and NLRP3 oligomerization (PubMed:37575012). {ECO:0000250|UniProtKB:Q9NX47, ECO:0000269|PubMed:36329234, ECO:0000269|PubMed:37575012}.
uniprot
proteins
mass_dalton
31232
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated leading to degradation. {ECO:0000250|UniProtKB:Q9NX47}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
36329234
uniprot
proteins
pubmed
37575012
uniprot
proteins
sequence_length
278
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9NX47}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9NX47}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 99..119; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 139..159; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 209..229; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 238..258; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins