Pdcd4
entrez
18569
canonical
uniprot
Q61823
canonical
ensembl
ENSMUSG00000024975
resolver
ensp
ENSMUSP00000025931
resolver
ensp
ENSMUSP00000073975
resolver
ensp
ENSMUSP00000133135
resolver
ensp
ENSMUSP00000261944
resolver
ensp
ENSMUSP00000261945
resolver
ensp
ENSMUSP00000261946
resolver
enst
ENSMUST00000025931
resolver
enst
ENSMUST00000074371
resolver
enst
ENSMUST00000165617
resolver
genesymbol
Pdcd4
resolver
genesymbol_syn
Ma3
resolver
genesymbol_syn
Tis
resolver
uniprot
P97296
resolver
uniprot
Q3T9A9
resolver
uniprot_entry
PDCD4_MOUSE
resolver
uniprot_sec
P97296
resolver
uniprot_sec
Q3T9A9
resolver
amino_acid_sequence
MDIENEQTLNVNPTDPDNLSDSLFSGDEENAGTEEIKNEINGNWISASTINEARINAKAKRRLRKNSSRDSGRGDSVSDNGSEAVRSGVAVPTSPKGRLLDRRSRSGKGRGLPKKGGAGGKGVWGTPGQVYDVEEVDVKDPNYDDDQENCVYETVVLPLDETAFEKTLTPIIQEYFEHGDTNEVAEMLRDLNLGEMKSGVPVLAVSLALEGKASHREMTSKLLSDLCGTVMSTNDVEKSFDKLLKDLPELALDTPRAPQLVGQFIARAVGDGILCNTYIDSYKGTVDCVQARAALDKATVLLSMSKGGKRKDSVWGSGGGQQPVNHLVKEIDMLLKEYLLSGDISEAEHCLKELEVPHFHHELVYEAIVMVLESTGESAFKMILDLLKSLWKSSTITIDQMKRGYERIYNEIPDINLDVPHSYSVLERFVEECFQAGIISKQLRDLCPSRGRKRFVSEGDGGRLKPESY
uniprot
proteins
disease_involvement
DISEASE: Note=Decreases benign tumor development and malignant progression. {ECO:0000305|PubMed:16024603}.
uniprot
proteins
function
FUNCTION: Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA. {ECO:0000269|PubMed:12482958, ECO:0000269|PubMed:12894233, ECO:0000269|PubMed:16024603, ECO:0000269|PubMed:17060447}.
uniprot
proteins
mass_dalton
51702
uniprot
proteins
mutagenesis
MUTAGEN 414; /note="D->A: Strongly reduced interaction with EIF4A1."; /evidence="ECO:0000269|PubMed:17060447"; MUTAGEN 418; /note="D->A: Strongly reduced interaction with EIF4A1."; /evidence="ECO:0000269|PubMed:17060447"; MUTAGEN 457; /note="S->A,D: No effect on interaction with EIF4A1."; /evidence="ECO:0000269|PubMed:17060447
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated, leading to its proteasomal degradation. Rapidly degraded in response to mitogens. Phosphorylation of the phosphodegron promotes interaction with BTRC and proteasomal degradation (By similarity). {ECO:0000250}.; PTM: Phosphorylated at Ser-67 by RPS6KB1 in response to mitogens; phosphorylation promotes proteasomal degradation of PDCD4. {ECO:0000250}.
uniprot
proteins
protein_family
PDCD4 family
uniprot
proteins
pubmed
12482958
uniprot
proteins
pubmed
12894233
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16024603
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16682971
uniprot
proteins
pubmed
17060447
uniprot
proteins
pubmed
17310995
uniprot
proteins
pubmed
19153607
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8543179
uniprot
proteins
pubmed
8912629
uniprot
proteins
pubmed
9714845
uniprot
proteins
sequence_length
469
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12894233}. Cytoplasm {ECO:0000269|PubMed:12894233}. Note=Shuttles between the nucleus and cytoplasm (PubMed:12894233). Predominantly nuclear under normal growth conditions, and when phosphorylated at Ser-457 (By similarity). {ECO:0000250|UniProtKB:Q53EL6, ECO:0000269|PubMed:12894233}.
uniprot
proteins