Stxbp5
entrez
81022
canonical
uniprot
Q9WU70
canonical
ensembl
ENSRNOG00000013351
resolver
ensembl
ENSRNOG00055009440
resolver
ensembl
ENSRNOG00060005920
resolver
ensembl
ENSRNOG00065024826
resolver
ensp
ENSRNOP00000044738
resolver
ensp
ENSRNOP00000049322
resolver
ensp
ENSRNOP00000092947
resolver
ensp
ENSRNOP00000099537
resolver
enst
ENSRNOT00000040559
resolver
enst
ENSRNOT00000115103
resolver
genesymbol
Stxbp5
resolver
genesymbol_syn
Llgl3
resolver
uniprot
A0A8I6AIJ8
resolver
uniprot
A0A8L2QLQ5
resolver
uniprot
Q9WU71
resolver
uniprot
Q9Z152
resolver
uniprot_entry
A0A8I6AIJ8_RAT
resolver
uniprot_entry
A0A8L2QLQ5_RAT
resolver
uniprot_entry
STXB5_RAT
resolver
uniprot_sec
Q9WU71
resolver
uniprot_sec
Q9Z152
resolver
amino_acid_sequence
MRKFNIRKVLDGLTAGSSSASQQQQQQQHPPGNREPEIQETLQSEHFQLCKTVRHGFPYQPSALAFDPVQKILAVGTQTGALRLFGRPGVECYCQHDSGAAVIQLQFLINEGALVSALADDTLHLWNLRQKRPAVLHSLKFCRERVTFCHLPFQSKWLYVGTERGNIHIVNVESFTLSGYVIMWNKAIELSSKSHPGPVVHISDNPMDEGKLLIGFESGTVVLWDLKSKKADYRYTYDEAIHSVAWHHEGKQFICSHSDGTLTIWNVRSPTKPVQTITPHGKQLKDGKKPEPCKPILKVEFKTTRSGEPFIILSGGLSYDTVGRRPCLTVMHGKSTAVLEMDYSIVDFLTLCETPYPNDFQEPYAVVVLLEKDLVLIDLAQNGYPIFENPYPLSIHESPVTCCEYFADCPVDLIPALYSVGARQKRQGYSKKEWPINGGNWGLGAQSYPEIIITGHADGSIKFWDASAITLQVLYKLKTSKVFEKSRNKDDRQNTDIVDEDPYAIQIISWCPESRMLCIAGVSAHVIIYRFSKQEVVTEVIPMLEVRLLYEINDVETPEGEQPPPLSTPVGSSTSQPIPPQSHPSTSSSSSDGLRDNVPCLKVKNSPLKQSPGYQTELVIQLVWVGGEPPQQITSLALNSSYGLVVFGNSNGIAMVDYLQKAVLLNLSTIELYGSNDPYRREPRSPRKSRQPSGAGLCDITEGTVVPEDRCKSPTSGSSSPHNSDDEQKVNNFIEKVKTQSRKFSKMVASDLAKMSRKLSLPTDLKPDLDVKDNSFSRSRSSSVTSIDKESREAISALHFCETFTRKADSSPSPCLWVGTTVGTAFVITLNLPLGPEQRLLQPVIVSPSGTILRLKGAILRMAFLDAAGCLMPPAYEPWTEHNVPEEKDEKEKLKKRRPVSVSPSSSQEISENQYAVICSEKQAKVISLPTQNCAYKQNITETSFVLRGDIVALSNSVCLACFCANGHIMTFSLPSLRPLLDVYYLPLTNMRIARTFCFANSGQALYLVSPTEIQRLTYSQETCENLQEMLGELFTPVETPEAPNRGFFKGLFGGGAQSLDREELFGESSSGKASRSLAQHIPGPGGIEGVKGAASGVVGELARARLALDERGQKLSDLEERTAAMMSSADSFSKHAHEMMLKYKDKKWYQF
uniprot
proteins
function
FUNCTION: Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane (By similarity). Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Competes with STXBP1 for STX1 binding. {ECO:0000250, ECO:0000269|PubMed:9620695}.
uniprot
proteins
mass_dalton
127659
uniprot
proteins
mutagenesis
MUTAGEN 724; /note="S->A: Strongly reduces phosphorylation."; /evidence="ECO:0000269|PubMed:16186257"; MUTAGEN 724; /note="S->D: Reduces interaction with STX1A."; /evidence="ECO:0000269|PubMed:16186257
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by PKA reduces interaction with STX1A and enhances synaptic neurotransmitter release. {ECO:0000269|PubMed:16186257}.
uniprot
proteins
protein_family
WD repeat L(2)GL family
uniprot
proteins
pubmed
10066450
uniprot
proteins
pubmed
15316007
uniprot
proteins
pubmed
16186257
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9620695
uniprot
proteins
sequence_length
1152
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9620695}. Cell membrane {ECO:0000269|PubMed:9620695}; Peripheral membrane protein {ECO:0000269|PubMed:9620695}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:9620695}; Peripheral membrane protein {ECO:0000269|PubMed:9620695}. Synapse {ECO:0000269|PubMed:9620695}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000269|PubMed:9620695}. Note=Cytoplasmic, and associated with vesicular membranes and the plasma membrane. Detected at synapses and on synaptic vesicles.
uniprot
proteins