Fcgr4
entrez
246256
canonical
uniprot
A0A0B4J1G0
canonical
ensembl
ENSMUSG00000059089
resolver
ensp
ENSMUSP00000077873
resolver
enst
ENSMUST00000078825
resolver
genesymbol
Fcgr4
resolver
genesymbol_syn
Fcgr3a
resolver
uniprot
Q3TC44
resolver
uniprot
Q8R2R4
resolver
uniprot
Q8R477
resolver
uniprot_entry
FCG3A_MOUSE
resolver
uniprot_sec
Q3TC44
resolver
uniprot_sec
Q8R2R4
resolver
uniprot_sec
Q8R477
resolver
amino_acid_sequence
MWQLLLPTALVLTAFSGIQAGLQKAVVNLDPKWVRVLEEDSVTLRCQGTFSPEDNSIKWFHNESLIPHQDANYVIQSARVKDSGMYRCQTALSTISDPVQLEVHMGWLLLQTTKWLFQEGDPIHLRCHSWQNRPVRKVTYLQNGKGKKYFHENSELLIPKATHNDSGSYFCRGLIGHNNKSSASFRISLGDPGSPSMFPPWHQITFCLLIGLLFAIDTVLYFSVRRGLQSPVADYEEPKIQWSKEPQDK
uniprot
proteins
function
FUNCTION: Receptor for the invariable Fc fragment of immunoglobulin gamma (IgG) (PubMed:16039578). Binds with intermediate affinity to both IgG2a and IgG2b (PubMed:16039578, PubMed:17558411, PubMed:19795417). Can bind to IgG2a and IgG2b monomers (PubMed:18949059). Does not display binding to IgG1 or IgG3 (PubMed:16039578). Recognizes neutralizing virus-specific IgGs displayed on the cell surface of infected cells and triggers antibody-dependent cellular cytotoxicity (ADCC). Confers protection to lethal influenza virus infection (PubMed:24412922). On splenic dendritic cells, uptakes antigen immune complexes and efficiently divert them into MHC class I and II antigen presentation pathways to provide for superior priming of CD4-positive and CD8-positive T cell immune responses (PubMed:28389502). Mediates neutrophil activation by IgG complexes redundantly with FCGR2A (PubMed:18097064). Plays a role in promoting bone resorption by enhancing osteoclast differentiation following binding to IgG2a (PubMed:25824719). Also acts as a receptor for the Fc region of immunoglobulin epsilon (IgE) (PubMed:17558411, PubMed:18949059). Binds with low affinity to both the a and b allotypes of IgE (PubMed:18949059). Has also been shown to bind to IgE allotype a only but not to allotype b (PubMed:17558411). Binds aggregated IgE but not the monomeric form and bound monomeric IgG is readily displaced by IgE complexes (PubMed:18949059). Binding to IgE promotes macrophage-mediated phagocytosis, antigen presentation to T cells, production of pro-inflammatory cytokines and the late phase of cutaneous allergic reactions (PubMed:17558411, PubMed:18949059). Mediates enhanced ADCC in response to afucosylated IgGs (PubMed:34485821). {ECO:0000269|PubMed:16039578, ECO:0000269|PubMed:17558411, ECO:0000269|PubMed:18097064, ECO:0000269|PubMed:18949059, ECO:0000269|PubMed:19795417, ECO:0000269|PubMed:24412922, ECO:0000269|PubMed:25824719, ECO:0000269|PubMed:28389502, ECO:0000269|PubMed:34485821}.
uniprot
proteins
mass_dalton
28398
uniprot
proteins
mutagenesis
MUTAGEN 235; /note="Y->W: Abolishes receptor ligation-induced phosphorylation."; /evidence="ECO:0000269|PubMed:17558411
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:16039578, ECO:0000269|PubMed:18949059}.; PTM: Phosphorylated following receptor ligation. {ECO:0000269|PubMed:17558411}.
uniprot
proteins
pubmed
12389094
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16039578
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17558411
uniprot
proteins
pubmed
18097064
uniprot
proteins
pubmed
18292508
uniprot
proteins
pubmed
18949059
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19795417
uniprot
proteins
pubmed
24412922
uniprot
proteins
pubmed
25824719
uniprot
proteins
pubmed
28389502
uniprot
proteins
pubmed
34485821
uniprot
proteins
pubmed
7955033
uniprot
proteins
sequence_length
249
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16039578, ECO:0000269|PubMed:17558411, ECO:0000269|PubMed:28389502}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 204..224; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins