Pi4k2b
entrez
305419
canonical
uniprot
Q5XIL2
canonical
ensembl
ENSRNOG00000003924
resolver
ensembl
ENSRNOG00055010692
resolver
ensembl
ENSRNOG00060016830
resolver
ensembl
ENSRNOG00065002996
resolver
ensp
ENSRNOP00000103557
resolver
ensp
ENSRNOP00055014518
resolver
ensp
ENSRNOP00060023185
resolver
ensp
ENSRNOP00065002988
resolver
enst
ENSRNOT00000171326
resolver
enst
ENSRNOT00055018075
resolver
enst
ENSRNOT00060028812
resolver
enst
ENSRNOT00065004201
resolver
genesymbol
Pi4k2b
resolver
uniprot_entry
P4K2B_RAT
resolver
amino_acid_sequence
MPEPPRDIMAEACEATRPSEDEDEEREPLLPRVAWAQPRRGAPGSAVRLQADQGAAVLREPATEEPPVVSEDRSISASLSTELDRTRNAVSETNTFLEDPEFADVVLKAEQAIEIGVFPERISQGSSGSYFVKDSKRTIIGVFKPKSEEPYGQLNPKWTKYVHKVCCPCCFGRGCLLPNQGYLSEAGAYLVDTKLQLGIVPKTKVVWLVSETFNYSAIDRAKSRGKKYALEKVPKVGRKFHRIGLPPKIGSFQLFVKDYKEAEYWLRRFEAEPLPENIRKQFQSQFERLVILDYIIRNTDRGNDNWLVKYDEMKYAKKIESEESNWIDDKQLLIRIAAIDNGLAFPFKHPDEWRAYPFHWAWLPQAKVPFSEETRNLILPFISDMNFVQDLCEDLYELFKTDKGFDRAAFESQMSVMRGQILNLTQALRDGKSPMQLAQMPCVIVECSKSGGQGRVVHLGSSFTQTVHCRKPFFSSW
uniprot
proteins
ec_number
2.7.1.67
uniprot
proteins
function
FUNCTION: Together with PI4K2A and the type III PI4Ks (PIK4CA and PIK4CB) it contributes to the overall PI4-kinase activity of the cell. This contribution may be especially significant in plasma membrane, endosomal and Golgi compartments. The phosphorylation of phosphatidylinositol (PI) to PI4P is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3). Contributes to the production of InsP3 in stimulated cells and is likely to be involved in the regulation of vesicular trafficking. {ECO:0000250|UniProtKB:Q8TCG2}.
uniprot
proteins
mass_dalton
54464
uniprot
proteins
protein_family
PI3/PI4-kinase family
uniprot
proteins
protein_family
Type II PI4K subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
477
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8TCG2}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q8TCG2}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8TCG2}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8TCG2}. Cell membrane {ECO:0000250|UniProtKB:Q8TCG2}. Early endosome membrane {ECO:0000250|UniProtKB:Q8TCG2}. Note=Mainly cytosolic, association with membranes of the Golgi, endoplasmic and plasma membrane is stimulated by active RAC1. Association with early endosomes has not been confirmed. {ECO:0000250|UniProtKB:Q8TCG2}.
uniprot
proteins