Tph1
entrez
21990
canonical
uniprot
P17532
canonical
ensembl
ENSMUSG00000040046
resolver
ensp
ENSMUSP00000037752
resolver
ensp
ENSMUSP00000103296
resolver
ensp
ENSMUSP00000128107
resolver
enst
ENSMUST00000049298
resolver
enst
ENSMUST00000107669
resolver
enst
ENSMUST00000168335
resolver
genesymbol
Tph1
resolver
genesymbol_syn
Tph
resolver
uniprot
F6R9U9
resolver
uniprot
Q3TZH2
resolver
uniprot
Q3UK52
resolver
uniprot
Q9JHZ8
resolver
uniprot_entry
F6R9U9_MOUSE
resolver
uniprot_entry
Q3TZH2_MOUSE
resolver
uniprot_entry
Q3UK52_MOUSE
resolver
uniprot_entry
Q9JHZ8_MOUSE
resolver
uniprot_entry
TPH1_MOUSE
resolver
amino_acid_sequence
MIEDNKENKENKDHSSERGRVTLIFSLENEVGGLIKVLKIFQENHVSLLHIESRKSKQRNSEFEIFVDCDISREQLNDIFPLLKSHATVLSVDSPDQLTAKEDVMETVPWFPKKISDLDFCANRVLLYGSELDADHPGFKDNVYRRRRKYFAELAMNYKHGDPIPKIEFTEEEIKTWGTIFRELNKLYPTHACREYLRNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPLYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEETVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKIACKQECLITSFQDVYFVSESFEDAKEKMREFAKTVKRPFGLKYNPYTQSVQVLRDTKSITSAMNELRYDLDVISDALARVTRWPSV
uniprot
proteins
ec_number
1.14.16.4
uniprot
proteins
function
FUNCTION: Oxidizes L-tryptophan to 5-hydroxy-l-tryptophan in the rate-determining step of serotonin biosynthesis. {ECO:0000269|PubMed:14697203, ECO:0000305|PubMed:2110547}.
uniprot
proteins
mass_dalton
51343
uniprot
proteins
pathway_participation
PATHWAY: Aromatic compound metabolism; serotonin biosynthesis; serotonin from L-tryptophan: step 1/2. {ECO:0000305|PubMed:2110547}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, leading to its degradation by the proteasome. Ubiquitinated is triggered by phosphorylation. {ECO:0000250|UniProtKB:P09810}.; PTM: Phosphorylated; triggering degradation by the proteasome. {ECO:0000250|UniProtKB:P09810}.
uniprot
proteins
protein_family
Biopterin-dependent aromatic amino acid hydroxylase family
uniprot
proteins
pubmed
14697203
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2110547
uniprot
proteins
pubmed
39695187
uniprot
proteins
sequence_length
447
uniprot
proteins