Ciapin1
entrez
109006
canonical
uniprot
Q8WTY4
canonical
ensembl
ENSMUSG00000031781
resolver
ensp
ENSMUSP00000034233
resolver
ensp
ENSMUSP00000125451
resolver
enst
ENSMUST00000034233
resolver
enst
ENSMUST00000162538
resolver
genesymbol
Ciapin1
resolver
uniprot
Q3UJW5
resolver
uniprot
Q8VC24
resolver
uniprot
Q91W83
resolver
uniprot_entry
CPIN1_MOUSE
resolver
uniprot_sec
Q3UJW5
resolver
uniprot_sec
Q8VC24
resolver
uniprot_sec
Q91W83
resolver
amino_acid_sequence
MEEFGISPGQLVAVFWDKSSPEEALKKLVARLQELTGSEGQVFMENVTQLLQSSHKESSFDVILSGVVPGSTSLHSAEVLAEMARILRPGGCLFLKEPVETAEVNNDKMKTASKLCSALTLSGLVEIKELQREALSPEEVQSVQEHLGYHSDSLRSVRVTGKKPNFEVGSSSQLKLPNKKSSSVKPVVDPAAAKLWTLSANDMEDDSVDLIDSDELLDPEDLKRPDPASLKAPSCGEGKKRKACKNCTCGLAEELEREQSKAQSSQPKSACGNCYLGDAFRCANCPYLGMPAFKPGEQVLLSNSNLQDA
uniprot
proteins
function
FUNCTION: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (PubMed:14970183). {ECO:0000255|HAMAP-Rule:MF_03115, ECO:0000269|PubMed:14970183}.
uniprot
proteins
mass_dalton
33429
uniprot
proteins
protein_family
Anamorsin family
uniprot
proteins
pubmed
14970183
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16957168
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
309
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03115}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03115}. Mitochondrion intermembrane space {ECO:0000255|HAMAP-Rule:MF_03115}.
uniprot
proteins