Cbr4
entrez
359725
canonical
uniprot
Q7TS56
canonical
ensembl
ENSRNOG00055013156
resolver
ensembl
ENSRNOG00060014978
resolver
ensembl
ENSRNOG00065004127
resolver
ensp
ENSRNOP00055018314
resolver
ensp
ENSRNOP00060020485
resolver
ensp
ENSRNOP00065004306
resolver
enst
ENSRNOT00055022547
resolver
enst
ENSRNOT00060025658
resolver
enst
ENSRNOT00065006019
resolver
genesymbol
Cbr4
resolver
uniprot_entry
CBR4_RAT
resolver
amino_acid_sequence
MDKVCAVFGGSRGIGKAVAQLMAQKGYRLAIVARNLEVAKATASELGGIHLAFRCNIAKEGDVHSTFEEMEKHLGPVNFLVNAAGINRDSLLVRTKTEDMLSQLHTNLLGTMLTCRAAMRTMIQQGGSIVNVGSIIGLKGNVGQAAYSATKGGLIGFSRSLAKEVARKKIRVNVVAPGFIHTDMTKHLKEEHFKKNIPLGRFGEALEVAHAVVFLLESPYITGHVLIVDGGLQLTA
uniprot
proteins
ec_number
1.1.1.100
uniprot
proteins
ec_number
1.6.5.10
uniprot
proteins
function
FUNCTION: Component of the heterotetramer complex KAR (3-ketoacyl-[acyl carrier protein] reductase or 3-ketoacyl-[ACP] reductase) that forms part of the mitochondrial fatty acid synthase (mtFAS). Beta-subunit of the KAR heterotetramer complex, responsible for the 3-ketoacyl-ACP reductase activity of the mtFAS, reduces 3-oxoacyl-[ACP] to (3R)-hydroxyacyl-[ACP] in a NADPH-dependent manner with no chain length preference, thereby participating in mitochondrial fatty acid biosynthesis. The homotetramer has NADPH-dependent quinone reductase activity (in vitro), hence could play a role in protection against cytotoxicity of exogenous quinones. As a heterotetramer, it can also reduce 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro). {ECO:0000250|UniProtKB:Q8N4T8}.
uniprot
proteins
mass_dalton
25287
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000250|UniProtKB:Q8N4T8}.
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
236
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:Q8N4T8}.
uniprot
proteins