Mbnl2
entrez
680445
canonical
uniprot
F2Z3T4
canonical
ensembl
ENSRNOG00000010737
resolver
ensembl
ENSRNOG00055011963
resolver
ensembl
ENSRNOG00060008659
resolver
ensembl
ENSRNOG00065007429
resolver
ensp
ENSRNOP00000014300
resolver
ensp
ENSRNOP00000077342
resolver
ensp
ENSRNOP00000089857
resolver
ensp
ENSRNOP00000094173
resolver
ensp
ENSRNOP00000099124
resolver
ensp
ENSRNOP00000112436
resolver
ensp
ENSRNOP00055016417
resolver
ensp
ENSRNOP00060011186
resolver
ensp
ENSRNOP00065008503
resolver
enst
ENSRNOT00000014300
resolver
enst
ENSRNOT00000095906
resolver
enst
ENSRNOT00000109835
resolver
enst
ENSRNOT00000116108
resolver
enst
ENSRNOT00000173246
resolver
enst
ENSRNOT00055020364
resolver
enst
ENSRNOT00060014529
resolver
enst
ENSRNOT00065011654
resolver
genesymbol
Mbnl2
resolver
uniprot
A0A8I5Y5P3
resolver
uniprot
A0A8I6ACI9
resolver
uniprot
A0A8I6AKC8
resolver
uniprot
A0ABK0KX17
resolver
uniprot_entry
A0A8I5Y5P3_RAT
resolver
uniprot_entry
A0A8I6ACI9_RAT
resolver
uniprot_entry
A0A8I6AKC8_RAT
resolver
uniprot_entry
A0ABK0KX17_RAT
resolver
uniprot_entry
MBNL2_RAT
resolver
amino_acid_sequence
MALNVAPVRDTKWLTLEVCRQYQRGTCSRSDEECKFAHPPKSCQVENGRVIACFDSLKGRCSRENCKYLHPPTHLKTQLEINGRNNLIQQKTAAAMLAQQMQFMFPGTPLHPVPTFPVGPTIGTNAAISFAPYLAPVTPGVGLVPTEVLPTTPVIVPGSPPVTVPGSTATQKLLRTDKLEVCREFQRGNCARGETDCRFAHPADSTMIDTNDNTVTVCMDYIKGRCMREKCKYFHPPAHLQAKIKAAQHQANQAAVAAQAAAAAATVMTQSTAKALKRPLEATVDLAFPPGALHPLPKRQALEKSNGASTVFNPSVLHYQQALTSAQLQQHTAFIPTVPMMHSATSATVSAATTPATSVPFAATATANQIILK
uniprot
proteins
function
FUNCTION: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. RNA-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. Binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target RNAs. Together with RNA binding proteins RBPMS and RBFOX2, activates vascular smooth muscle cells alternative splicing events (PubMed:37548402). Regulates NCOR2 alternative splicing (PubMed:31283468). Seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. May play a role in myotonic dystrophy pathophysiology (DM) (By similarity). {ECO:0000250, ECO:0000269|PubMed:31283468, ECO:0000269|PubMed:37548402}.
uniprot
proteins
mass_dalton
40156
uniprot
proteins
protein_family
Muscleblind family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
19457059
uniprot
proteins
pubmed
31283468
uniprot
proteins
pubmed
37548402
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q5VZF2}. Cytoplasm {ECO:0000250|UniProtKB:Q5VZF2}. Note=Greater concentration in the nucleus. Expressed in or near large cytoplasmic adhesion plaques. Location in the cytoplasm is microtubule-dependent. {ECO:0000250|UniProtKB:Q5VZF2}.
uniprot
proteins