AHCYL2
entrez
23382
canonical
uniprot
Q96HN2
canonical
ensembl
ENSG00000158467
resolver
ensp
ENSP00000315931
resolver
ensp
ENSP00000413639
resolver
ensp
ENSP00000420459
resolver
ensp
ENSP00000420801
resolver
ensp
ENSP00000610617
resolver
genesymbol
AHCYL2
resolver
genesymbol_syn
KIAA0828
resolver
hgnc
HGNC:22204
resolver
uniprot
B4DIZ5
resolver
uniprot
D9N155
resolver
uniprot
O94917
resolver
uniprot_entry
SAHH3_HUMAN
resolver
uniprot_sec
B4DIZ5
resolver
uniprot_sec
D9N155
resolver
uniprot_sec
O94917
resolver
amino_acid_sequence
MSVQVVSAAAAAKVPEVELKDLSPSEAESQLGLSTAAVGAMAPPAGGGDPEAPAPAAERPPVPGPGSGPAAALSPAAGKVPQASAMKRSDPHHQHQRHRDGGEALVSPDGTVTEAPRTVKKQIQFADQKQEFNKRPTKIGRRSLSRSISQSSTDSYSSAASYTDSSDDETSPRDKQQKNSKGSSDFCVKNIKQAEFGRREIEIAEQEMPALMALRKRAQGEKPLAGAKIVGCTHITAQTAVLMETLGALGAQCRWAACNIYSTLNEVAAALAESGFPVFAWKGESEDDFWWCIDRCVNVEGWQPNMILDDGGDLTHWIYKKYPNMFKKIKGIVEESVTGVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDNLYCCRESILDGLKRTTDMMFGGKQVVVCGYGEVGKGCCAALKAMGSIVYVTEIDPICALQACMDGFRLVKLNEVIRQVDIVITCTGNKNVVTREHLDRMKNSCIVCNMGHSNTEIDVASLRTPELTWERVRSQVDHVIWPDGKRIVLLAEGRLLNLSCSTVPTFVLSITATTQALALIELYNAPEGRYKQDVYLLPKKMDEYVASLHLPTFDAHLTELTDEQAKYLGLNKNGPFKPNYYRY
uniprot
proteins
function
FUNCTION: Regulatory protein that interacts with and modulates the activity of membrane ion transporters, including the sodium-bicarbonate cotransporter SLC4A4, through phosphorylation-dependent binding. Functions as a homolog of AHCYL1 to regulate bicarbonate transport and intracellular pH homeostasis via direct interactions rather than enzymatic activity (By similarity). On the contrary of its homolog AHCYL1, does not regulate ITPR1 sensitivity to inositol 1,4,5-trisphosphate (PubMed:19220705). {ECO:0000250|UniProtKB:A6QLP2, ECO:0000250|UniProtKB:Q68FL4, ECO:0000269|PubMed:19220705}.
uniprot
proteins
mass_dalton
66721
uniprot
proteins
post_translational_modification
PTM: Phosphorylated during neuronal differentiation at the LISN domain. {ECO:0000250|UniProtKB:Q68FL4}.
uniprot
proteins
protein_family
Adenosylhomocysteinase family
uniprot
proteins
pubmed
10048485
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19220705
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
31799605
uniprot
proteins
sequence_length
611
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A6QLP2, ECO:0000250|UniProtKB:Q68FL4}. Microsome {ECO:0000250|UniProtKB:Q68FL4}. Note=Associates with membranes when phosphorylated, probably through interaction with ITPR1. {ECO:0000250|UniProtKB:Q68FL4}.
uniprot
proteins