TCF15
entrez
6939
canonical
uniprot
Q12870
canonical
ensembl
ENSG00000125878
resolver
ensp
ENSP00000246080
resolver
enst
ENST00000246080
resolver
genesymbol
TCF15
resolver
genesymbol_syn
BHLHA40
resolver
genesymbol_syn
BHLHEC2
resolver
hgnc
HGNC:11627
resolver
uniprot
Q6NVX3
resolver
uniprot
Q9NQQ1
resolver
uniprot_entry
Q6NVX3_HUMAN
resolver
uniprot_entry
TCF15_HUMAN
resolver
uniprot_sec
Q9NQQ1
resolver
amino_acid_sequence
MAFALLRPVGAHVLYPDVRLLSEDEENRSESDASDQSFGCCEGPEAARRGPGPGGGRRAGGGGGAGPVVVVRQRQAANARERDRTQSVNTAFTALRTLIPTEPVDRKLSKIETVRLASSYIAHLANVLLLGDSADDGQPCFRAAGSAKGAVPAAADGGRQPRSICTFCLSNQRKGGGRRDLGGSCLKVRGVAPLRGPRR
uniprot
proteins
function
FUNCTION: Early transcription factor that plays a key role in somitogenesis, paraxial mesoderm development and regulation of stem cell pluripotency. Essential for the mesenchymal to epithelial transition associated with somite formation. Required for somite morphogenesis, thereby regulating patterning of the axial skeleton and skeletal muscles. Required for proper localization of somite epithelium markers during the mesenchymal to epithelial transition. Also plays a key role in regulation of stem cell pluripotency. Promotes pluripotency exit of embryonic stem cells (ESCs) by priming ESCs for differentiation. Acts as a key regulator of self-renewal of hematopoietic stem cells (HSCs) by mediating HSCs quiescence and long-term self-renewal. Together with MEOX2, regulates transcription in heart endothelial cells to regulate fatty acid transport across heart endothelial cells. Acts by forming a heterodimer with another helix-loop-helix (bHLH) protein, such as TCF3/E12, that binds DNA on E-box motifs (5'-CANNTG-3') and activates transcription of target genes. {ECO:0000250|UniProtKB:Q60756}.
uniprot
proteins
mass_dalton
20816
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
8041747
uniprot
proteins
sequence_length
199
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q60756, ECO:0000255|PROSITE-ProRule:PRU00981}.
uniprot
proteins