Kcnk1
entrez
59324
canonical
uniprot
Q9Z2T2
canonical
ensembl
ENSRNOG00000019937
resolver
ensembl
ENSRNOG00055005422
resolver
ensembl
ENSRNOG00060005448
resolver
ensembl
ENSRNOG00065018842
resolver
ensp
ENSRNOP00000027058
resolver
ensp
ENSRNOP00055006615
resolver
ensp
ENSRNOP00060006814
resolver
ensp
ENSRNOP00065025235
resolver
enst
ENSRNOT00000027058
resolver
enst
ENSRNOT00055008716
resolver
enst
ENSRNOT00060009039
resolver
enst
ENSRNOT00065031644
resolver
genesymbol
Kcnk1
resolver
uniprot_entry
KCNK1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by 100 uM quinine. Slightly inhibited by Ba(+) (PubMed:17452494). Activity is first increased and then decreased when the extracellular pH is lowered to 6.0 (PubMed:17452494, PubMed:22948150). {ECO:0000269|PubMed:17452494, ECO:0000269|PubMed:22948150}.
uniprot
proteins
amino_acid_sequence
MLQSLAGSSCVRLVERHRSAWCFGFLVLGYLLYLVFGAVVFSSVELPYEDLLRQELRKLKRRFLEEHECLSEPQLEQFLGRVLEASNYGVSVLSNASGNWNWDFTSALFFASTVLSTTGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLTAVVQRVTVHVTRRPVLYFHIRWGFSKQVVAIVHAVLLGFVTVSCFFFIPAAVFSVLEDDWNFLESFYFCFISLSTIGLGDYVPGEGYNQKFRELYKIGITCYLLLGLIAMLVVLETFCELHELKKFRKMFYVKKDKDEDQVHIMEHDQLSFSSITEQAAGLKEEQKQNEPFVASQSPPYEDGSANH
uniprot
proteins
function
FUNCTION: Ion channel that contributes to passive transmembrane potassium transport and to the regulation of the resting membrane potential in brain astrocytes, but also in kidney and in other tissues (PubMed:17452494, PubMed:19571146). Forms dimeric channels through which potassium ions pass in accordance with their electrochemical gradient (By similarity). The channel is selective for K(+) ions at physiological potassium concentrations and at neutral pH, but becomes permeable to Na(+) at subphysiological K(+) levels and upon acidification of the extracellular medium (PubMed:22948150). The homodimer has very low potassium channel activity, when expressed in heterologous systems, and can function as weakly inward rectifying potassium channel (By similarity). Channel activity is modulated by activation of serotonin receptors (PubMed:17452494). Heterodimeric channels containing KCNK1 and KCNK2 have much higher activity, and may represent the predominant form in astrocytes (By similarity). Heterodimeric channels containing KCNK1 and KCNK3 or KCNK9 have much higher activity (By similarity). Heterodimeric channels formed by KCNK1 and KCNK9 may contribute to halothane-sensitive currents (By similarity). Mediates outward rectifying potassium currents in dentate gyrus granule cells and contributes to the regulation of their resting membrane potential (By similarity). Contributes to the regulation of action potential firing in dentate gyrus granule cells and down-regulates their intrinsic excitability (By similarity). Contributes to the regulation of the resting membrane potential of pancreatic beta cells (By similarity). In astrocytes, the heterodimer formed by KCNK1 and KCNK2 is required for rapid glutamate release in response to activation of G protein-coupled receptors, such as F2R and CNR1 (By similarity). Required for normal ion and water transport in the kidney (By similarity). The low channel activity of homodimeric KCNK1 may be due to sumoylation (By similarity). The low channel activity may be due to rapid internalization from the cell membrane and retention in recycling endosomes (By similarity). Permeable to monovalent cations with ion selectivity for K(+) > Rb(+) >> NH4(+) >> Cs(+) = Na(+) = Li(+). {ECO:0000250|UniProtKB:O00180, ECO:0000250|UniProtKB:O08581, ECO:0000269|PubMed:17452494, ECO:0000269|PubMed:19571146, ECO:0000269|PubMed:22948150}.
uniprot
proteins
mass_dalton
38228
uniprot
proteins
mutagenesis
MUTAGEN 274; /note="K->E: Strongly increases channel activity."; /evidence="ECO:0000269|PubMed:19571146, ECO:0000269|PubMed:22948150
uniprot
proteins
post_translational_modification
PTM: Sumoylation is controversial. Sumoylated by UBE2I. Not sumoylated when expressed in xenopus oocytes or mammalian cells. Sumoylation inactivates the channel, but does not interfere with expression at the cell membrane. Sumoylation of a single subunit is sufficient to silence the dimeric channel. Sumoylation of KCNK1 is sufficient to silence heterodimeric channels formed by KCNK1 and KCNK3 or KCNK9. Desumoylated by SENP1; this activates the channel. Desumoylated by SENP1; this strongly increases halothane-mediated activation of heterodimeric channels formed with KCNK9. SENP1 treatment has no effect. {ECO:0000250|UniProtKB:O00180}.
uniprot
proteins
protein_family
Two pore domain potassium channel (TC 1.A.1.8) family
uniprot
proteins
pubmed
11567039
uniprot
proteins
pubmed
12855359
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17452494
uniprot
proteins
pubmed
18838117
uniprot
proteins
pubmed
19571146
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
22948150
uniprot
proteins
pubmed
23169818
uniprot
proteins
pubmed
25305496
uniprot
proteins
pubmed
25339226
uniprot
proteins
pubmed
25530075
uniprot
proteins
pubmed
9843722
uniprot
proteins
sequence_length
336
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17452494, ECO:0000269|PubMed:19571146, ECO:0000269|PubMed:22948150}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O00180}. Recycling endosome {ECO:0000250|UniProtKB:O00180}. Apical cell membrane {ECO:0000269|PubMed:12855359, ECO:0000269|PubMed:9843722}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O00180}. Cytoplasmic vesicle {ECO:0000269|PubMed:9843722}. Perikaryon {ECO:0000269|PubMed:18838117, ECO:0000269|PubMed:19571146}. Cell projection, dendrite {ECO:0000250|UniProtKB:O08581}. Cell projection {ECO:0000250|UniProtKB:O08581}. Synaptic cell membrane {ECO:0000269|PubMed:9843722}. Note=The heterodimer with KCNK2 is detected at the astrocyte cell membrane. Not detected at the astrocyte cell membrane when KCNK2 is absent. Detected on neuronal cell bodies, and to a lesser degree on neuronal cell projections (By similarity). Detected in synaptic membranes (PubMed:9843722). Detected at the apical cell membrane in stria vascularis in the cochlea (PubMed:12855359). Detected on hippocampus dentate gyrus granule cell bodies and to a lesser degree on proximal dendrites. Detected at the apical cell membrane of vestibular dark cells situated between the crista and the utricle in the inner ear. Detected at the apical cell membrane in kidney proximal tubule segment S1 and in subapical compartments in segments S1, S2 and S3 (PubMed:9843722). Predominantly in cytoplasmic structures in kidney distal convoluted tubules and collecting ducts (By similarity). Detected at the apical cell membrane of bronchial epithelial cells (By similarity). {ECO:0000250|UniProtKB:O00180, ECO:0000250|UniProtKB:O08581, ECO:0000269|PubMed:12855359, ECO:0000269|PubMed:9843722}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..41; /note="Helical; Name=M1"; /evidence="ECO:0000250|UniProtKB:O00180"; TRANSMEM 133..156; /note="Helical; Name=M2"; /evidence="ECO:0000250|UniProtKB:O00180"; TRANSMEM 182..202; /note="Helical; Name=M3"; /evidence="ECO:0000250|UniProtKB:O00180"; TRANSMEM 244..267; /note="Helical; Name=M4"; /evidence="ECO:0000250|UniProtKB:O00180
uniprot
proteins