Acot13
entrez
66834
canonical
uniprot
Q9CQR4
canonical
ensembl
ENSMUSG00000006717
resolver
ensp
ENSMUSP00000006900
resolver
enst
ENSMUST00000006900
resolver
genesymbol
Acot13
resolver
genesymbol_syn
Them2
resolver
uniprot
Q4VA32
resolver
uniprot_entry
ACO13_MOUSE
resolver
uniprot_entry
Q4VA32_MOUSE
resolver
amino_acid_sequence
MSSMTQNLREVMKVMFKVPGFDRVLEKVTLVSAAPEKLICEMKVEEQHTNKLGTLHGGLTATLVDSISTMALMCTERGAPGVSVDMNITYMSPAKIGEEIVITAHILKQGKTLAFASVDLTNKTTGKLIAQGRHTKHLGN
uniprot
proteins
ec_number
3.1.2.-
uniprot
proteins
ec_number
3.1.2.2
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:19405909). Has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates (PubMed:19405909). Can also hydrolyze 3-hydroxyphenylacetyl-CoA and 3,4-dihydroxyphenylacetyl-CoA (in vitro) (By similarity). May play a role in controlling adaptive thermogenesis (PubMed:24072708). {ECO:0000250|UniProtKB:Q9NPJ3, ECO:0000269|PubMed:19405909, ECO:0000269|PubMed:24072708}.
uniprot
proteins
mass_dalton
15183
uniprot
proteins
protein_family
Thioesterase PaaI family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17045243
uniprot
proteins
pubmed
17704541
uniprot
proteins
pubmed
19405909
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22345407
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
24072708
uniprot
proteins
sequence_length
140
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:17045243, ECO:0000269|PubMed:17704541, ECO:0000269|PubMed:19405909}. Mitochondrion {ECO:0000269|PubMed:19405909}. Nucleus {ECO:0000269|PubMed:17045243, ECO:0000269|PubMed:17704541}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:17045243}. Note=During interphase, found both in the nucleus and in the cytoplasm. At mitosis, localizes to the spindle. Colocalizes with tubulin. {ECO:0000269|PubMed:17045243}.
uniprot
proteins