Tmem165
entrez
21982
canonical
uniprot
P52875
canonical
ensembl
ENSMUSG00000029234
resolver
ensp
ENSMUSP00000031144
resolver
enst
ENSMUST00000031144
resolver
genesymbol
Tmem165
resolver
genesymbol_syn
Tparl
resolver
uniprot
Q9R292
resolver
uniprot_entry
TM165_MOUSE
resolver
uniprot_sec
Q9R292
resolver
amino_acid_sequence
MAAAARGSGRAPTRRLLVLLLLQLLWAPAGVRAGPEEDLSHRNQEPPAPAQQLQPQPAAVQGLEPARAEKGLTPVAPVHTNKEDAAAQTNLGFIHAFVAAISVIIVSELGDKTFFIAAIMAMRYNRLTVLAGAMLALALMTCLSVLFGYATTVIPRVYTYYVSTALFAIFGIRMLREGLKMSPDEGQEELEEVQAELKKKDEEFQRTKLLNGPDVETGTSTAIPQKKWLHFISPIFVQALTLTFLAEWGDRSQLTTIVLAAREDPYGVAVGGTVGHCLCTGLAVIGGRMIAQKISVRTVTIIGGIVFLAFAFSALFISPESGF
uniprot
proteins
function
FUNCTION: Putative divalent cation:proton antiporter that exchanges calcium or manganese ions for protons across the Golgi membrane. Mediates the reversible transport of calcium or manganese to the Golgi lumen driven by the proton gradient and possibly the membrane potential generated by V-ATPase. Provides calcium or manganese cofactors to resident Golgi enzymes and contributes to the maintenance of an acidic luminal Golgi pH required for proper functioning of the secretory pathway (By similarity). Promotes Ca(2+) storage within the Golgi lumen of the mammary epithelial cells to be then secreted into milk (PubMed:30622138). The transport mechanism and stoichiometry remains to be elucidated (By similarity). {ECO:0000250|UniProtKB:P38301, ECO:0000250|UniProtKB:Q9HC07, ECO:0000269|PubMed:30622138}.
uniprot
proteins
mass_dalton
34791
uniprot
proteins
protein_family
GDT1 family
uniprot
proteins
pubmed
11116088
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30622138
uniprot
proteins
pubmed
3202867
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:30622138}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 90..110; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 127..147; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 152..172; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 228..248; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 267..287; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 299..319; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins