STAMBP
entrez
10617
canonical
uniprot
O95630
canonical
ensembl
ENSG00000124356
resolver
ensp
ENSP00000344742
resolver
ensp
ENSP00000377633
resolver
ensp
ENSP00000377636
resolver
ensp
ENSP00000386548
resolver
ensp
ENSP00000506833
resolver
ensp
ENSP00000506958
resolver
ensp
ENSP00000507046
resolver
ensp
ENSP00000507054
resolver
ensp
ENSP00000507081
resolver
ensp
ENSP00000507089
resolver
ensp
ENSP00000507371
resolver
ensp
ENSP00000507643
resolver
ensp
ENSP00000507807
resolver
ensp
ENSP00000507864
resolver
ensp
ENSP00000643422
resolver
enst
ENST00000682423
resolver
enst
ENST00000682799
resolver
enst
ENST00000682851
resolver
enst
ENST00000682998
resolver
enst
ENST00000683349
resolver
genesymbol
STAMBP
resolver
genesymbol_syn
AMSH
resolver
hgnc
HGNC:16950
resolver
uniprot
A0A140VK54
resolver
uniprot
A0A804HIF8
resolver
uniprot
A0A804HII8
resolver
uniprot
A0A804HJ64
resolver
uniprot
B5M0B6
resolver
uniprot
D6W5H7
resolver
uniprot
Q3MJE7
resolver
uniprot_entry
A0A140VK54_HUMAN
resolver
uniprot_entry
A0A804HIF8_HUMAN
resolver
uniprot_entry
A0A804HII8_HUMAN
resolver
uniprot_entry
A0A804HJ64_HUMAN
resolver
uniprot_entry
STABP_HUMAN
resolver
uniprot_sec
B5M0B6
resolver
uniprot_sec
D6W5H7
resolver
uniprot_sec
Q3MJE7
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by N-ethylmaleimide (PubMed:15314065). Strongly and specifically inhibited by ubiquitin variants UbV(SP.2) and UbV(SP.3) (PubMed:34425109). Also inhibited by UbV(SP.1); an ubiquitin variant that also inhibits STAMBPL1 (PubMed:34425109). {ECO:0000269|PubMed:15314065, ECO:0000269|PubMed:34425109}.
uniprot
proteins
amino_acid_sequence
MSDHGDVSLPPEDRVRALSQLGSAVEVNEDIPPRRYFRSGVEIIRMASIYSEEGNIEHAFILYNKYITLFIEKLPKHRDYKSAVIPEKKDTVKKLKEIAFPKAEELKAELLKRYTKEYTEYNEEKKKEAEELARNMAIQQELEKEKQRVAQQKQQQLEQEQFHAFEEMIRNQELEKERLKIVQEFGKVDPGLGGPLVPDLEKPSLDVFPTLTVSSIQPSDCHTTVRPAKPPVVDRSLKPGALSNSESIPTIDGLRHVVVPGRLCPQFLQLASANTARGVETCGILCGKLMRNEFTITHVLIPKQSAGSDYCNTENEEELFLIQDQQGLITLGWIHTHPTQTAFLSSVDLHTHCSYQMMLPESVAIVCSPKFQETGFFKLTDHGLEEISSCRQKGFHPHSKDPPLFCSCSHVTVVDRAVTITDLR
uniprot
proteins
disease_involvement
DISEASE: Microcephaly-capillary malformation syndrome (MICCAP) [MIM:614261]: A congenital disorder characterized by severe progressive microcephaly, early-onset refractory epilepsy, profound developmental delay, and multiple small capillary malformations spread diffusely on the body. Additional more variable features include dysmorphic facial features, distal limb abnormalities, and mild heart defects. {ECO:0000269|PubMed:23542699}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.4.19.-
uniprot
proteins
function
FUNCTION: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:15314065, PubMed:23542699, PubMed:34425109). Does not cleave 'Lys-48'-linked polyubiquitin chains (PubMed:15314065). Plays a role in signal transduction for cell growth and MYC induction mediated by IL-2 and GM-CSF (PubMed:10383417). Potentiates BMP (bone morphogenetic protein) signaling by antagonizing the inhibitory action of SMAD6 and SMAD7 (PubMed:11483516). Has a key role in regulation of cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes (PubMed:15314065, PubMed:17261583). Endosomal localization of STAMBP is required for efficient EGFR degradation but not for its internalization (PubMed:15314065, PubMed:17261583). Involved in the negative regulation of PI3K-AKT-mTOR and RAS-MAP signaling pathways (PubMed:23542699). {ECO:0000269|PubMed:10383417, ECO:0000269|PubMed:11483516, ECO:0000269|PubMed:15314065, ECO:0000269|PubMed:17261583, ECO:0000269|PubMed:23542699, ECO:0000269|PubMed:34425109}.
uniprot
proteins
mass_dalton
48077
uniprot
proteins
mutagenesis
MUTAGEN 348; /note="D->A: Promotes accumulation of ubiquitin on endosomes, ablates enzymatic activity toward polyubiquitin substrate and allows ubiquitinated STAM stabilization."; /evidence="ECO:0000269|PubMed:15314065
uniprot
proteins
post_translational_modification
PTM: Phosphorylated after BMP type I receptor activation. {ECO:0000269|PubMed:11483516}.; PTM: Ubiquitinated by SMURF2 in the presence of RNF11. {ECO:0000269|PubMed:14755250}.
uniprot
proteins
protein_family
Peptidase M67C family
uniprot
proteins
pubmed
10383417
uniprot
proteins
pubmed
11483516
uniprot
proteins
pubmed
12370088
uniprot
proteins
pubmed
14755250
uniprot
proteins
pubmed
15314065
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17146056
uniprot
proteins
pubmed
17261583
uniprot
proteins
pubmed
19906316
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23542699
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
34425109
uniprot
proteins
sequence_length
424
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17261583, ECO:0000305|PubMed:10383417}. Membrane {ECO:0000269|PubMed:17261583}; Peripheral membrane protein {ECO:0000269|PubMed:17261583}. Cytoplasm {ECO:0000269|PubMed:17261583}. Early endosome {ECO:0000269|PubMed:15314065, ECO:0000269|PubMed:17261583}.
uniprot
proteins