Adam33
entrez
110751
canonical
uniprot
Q923W9
canonical
ensembl
ENSMUSG00000027318
resolver
ensp
ENSMUSP00000052486
resolver
ensp
ENSMUSP00000105861
resolver
ensp
ENSMUSP00000122608
resolver
ensp
ENSMUSP00000224407
resolver
genesymbol
Adam33
resolver
uniprot
A2AP51
resolver
uniprot
Q8R5G5
resolver
uniprot_entry
A2AP51_MOUSE
resolver
uniprot_entry
ADA33_MOUSE
resolver
uniprot_sec
Q8R5G5
resolver
amino_acid_sequence
MGSRCGRPGGSPVLLLLPLLLPSCPLRSARMFPGNAHGELVTPHWILEGRLWLKVTLEEPILKPDSVLVALEAEGQDLLLELEKKHKLLAPGYTETHYRPDGHPVVLSPNHTDHCQYHGRVRGFRESWVVLSTCSGMSGLIVLSSKVSYYLQPRTPGDTKDFPTHEIFRMEQLFTWRGVQRDKNSQYKAGMASLPHVPQSRVRREARRSPRYLELYIVADHTLFLLQHQNLNHTRQRLLEVANCVDQILRTLDIQLVLTGLEVWTEQDLSRITQDANETLWAFLQWRRGVWARRPHDSTQLLTGRTFQGTTVGLAPVEGICRAESSGGVSTDHSELPIGTAATMAHEIGHSLGLHHDPEGCCVQADAEQGGCVMEAATGHPFPRVFSACSRRQLRTFFRKGGGPCLSNTSAPGLLVLPSRCGNGFLEAGEECDCGSGQKCPDPCCFAHNCSLRAGAQCAHGDCCARCLLKSAGTPCRPAATDCDLPEFCTGTSPYCPADVYLLDGSPCAEGRGYCLDGWCPTLEQQCQQLWGPGSKPAPEPCFQQMNSMGNSQGNCGQDHKGSFLPCAQRDALCGKLLCQGGEPNPLVPHIVTMDSTILLEGREVVCRGAFVLPDSHLDQLDLGLVEPGTGCGPRMVCQDRHCQNATSQELERCLTACHNGGVCNSNRNCHCAAGWAPPFCDKPGLGGSVDSGPAQSANRDAFPLAMLLSFLLPLLPGAGLAWCYYQLPTFCHRRGLCCRRDPLWNRDIPLGSVHPVEFGSIITGEPSPPPPWTSCQQRSHPPSLDLLSDPANSELT
uniprot
proteins
ec_number
3.4.24.-
uniprot
proteins
function
FUNCTION: Metalloprotease that cleaves and sheds the ectodomains of cell-surface proteins and thereby contributes to angiogenesis, cell differentiation, inflammation, and cell proliferation. Modulates the activity of adhesion molecules and cytokines by generating soluble forms, leading to either attenuation of cell-surface signaling or initiation of downstream intracellular signaling pathways. For instance, acts as a constitutive sheddase of kit ligand/KITLG. Promotes and maintains a proliferative phenotype in vascular smooth muscle cells through regulation of the PI3K/AKT and ERK signaling pathways. Additionally, enhances cell migration and regulates cytokine secretion during airway vascular remodeling via the same signaling cascades. {ECO:0000250|UniProtKB:Q9BZ11}.
uniprot
proteins
mass_dalton
86971
uniprot
proteins
post_translational_modification
PTM: The precursor is cleaved by a furin endopeptidase. {ECO:0000250}.
uniprot
proteins
pubmed
11814695
uniprot
proteins
pubmed
16943435
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
797
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9BZ11}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9BZ11}.
uniprot
proteins
transmembrane_region
TRANSMEM 703..723; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins