DDAH2
entrez
23564
canonical
uniprot
O95865
canonical
ensembl
ENSG00000206395
resolver
ensembl
ENSG00000213722
resolver
ensembl
ENSG00000225635
resolver
ensembl
ENSG00000226634
resolver
ensembl
ENSG00000227317
resolver
ensembl
ENSG00000228128
resolver
ensembl
ENSG00000233076
resolver
ensp
ENSP00000364943
resolver
ensp
ENSP00000364945
resolver
ensp
ENSP00000364949
resolver
ensp
ENSP00000372901
resolver
ensp
ENSP00000382935
resolver
ensp
ENSP00000382936
resolver
ensp
ENSP00000389552
resolver
ensp
ENSP00000391632
resolver
ensp
ENSP00000391833
resolver
ensp
ENSP00000395372
resolver
ensp
ENSP00000395759
resolver
ensp
ENSP00000397466
resolver
ensp
ENSP00000399023
resolver
ensp
ENSP00000399357
resolver
ensp
ENSP00000402594
resolver
ensp
ENSP00000403154
resolver
ensp
ENSP00000404342
resolver
ensp
ENSP00000404851
resolver
ensp
ENSP00000405515
resolver
ensp
ENSP00000408148
resolver
ensp
ENSP00000409396
resolver
ensp
ENSP00000412327
resolver
ensp
ENSP00000412800
resolver
ensp
ENSP00000527451
resolver
ensp
ENSP00000527452
resolver
ensp
ENSP00000527453
resolver
ensp
ENSP00000640386
resolver
enst
ENST00000375787
resolver
enst
ENST00000375789
resolver
enst
ENST00000375792
resolver
enst
ENST00000383409
resolver
enst
ENST00000400062
resolver
enst
ENST00000400063
resolver
enst
ENST00000411456
resolver
enst
ENST00000413532
resolver
enst
ENST00000413655
resolver
enst
ENST00000414455
resolver
enst
ENST00000416410
resolver
enst
ENST00000424790
resolver
enst
ENST00000426149
resolver
enst
ENST00000427126
resolver
enst
ENST00000430482
resolver
enst
ENST00000434464
resolver
enst
ENST00000436437
resolver
enst
ENST00000437889
resolver
enst
ENST00000443533
resolver
enst
ENST00000444699
resolver
enst
ENST00000447101
resolver
enst
ENST00000451411
resolver
enst
ENST00000454138
resolver
enst
ENST00000857392
resolver
enst
ENST00000857393
resolver
enst
ENST00000857394
resolver
enst
ENST00000970327
resolver
genesymbol
DDAH2
resolver
genesymbol
HEL-S-277
resolver
genesymbol_syn
DDAH
resolver
genesymbol_syn
G6A
resolver
genesymbol_syn
NG30
resolver
hgnc
HGNC:2716
resolver
uniprot
A2BEZ7
resolver
uniprot
V9HW53
resolver
uniprot_entry
DDAH2_HUMAN
resolver
uniprot_entry
V9HW53_HUMAN
resolver
uniprot_sec
A2BEZ7
resolver
amino_acid_sequence
MGTPGEGLGRCSHALIRGVPESLASGEGAGAGLPALDLAKAQREHGVLGGKLRQRLGLQLLELPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDGVRKALQDLGLRIVEIGDENATLDGTDVLFTGREFFVGLSKWTNHRGAEIVADTFRDFAVSTVPVSGPSHLRGLCGMGGPRTVVAGSSDAAQKAVRAMAVLTDHPYASLTLPDDAAADCLFLRPGLPGVPPFLLHRGGGDLPNSQEALQKLSDVTLVPVSCSELEKAGAGLSSLCLVLSTRPHS
uniprot
proteins
ec_number
3.-.-.-
uniprot
proteins
function
FUNCTION: Putative hydrolase with unknown substrate (Probable). Does not hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA) which acts as an inhibitor of NOS (PubMed:21493890, PubMed:37296100). In endothelial cells, induces expression of vascular endothelial growth factor (VEGF) via phosphorylation of the transcription factor SP1 by PKA in a process that is independent of NO and NO synthase (By similarity). Similarly, enhances pancreatic insulin secretion through SP1-mediated transcriptional up-regulation of secretagogin/SCGN, an insulin vesicle docking protein (By similarity). Upon viral infection, relocates to mitochondria where it promotes mitochondrial fission through activation of DNM1L leading to the inhibition of innate response activation mediated by MAVS (PubMed:33850055). {ECO:0000250|UniProtKB:Q99LD8, ECO:0000269|PubMed:21493890, ECO:0000269|PubMed:33850055, ECO:0000269|PubMed:37296100, ECO:0000305|PubMed:10493931, ECO:0000305|PubMed:21493890, ECO:0000305|PubMed:37296100}.
uniprot
proteins
mass_dalton
29644
uniprot
proteins
mutagenesis
MUTAGEN 68; /note="S->D: No effect on inhibition of MAVS-mediated innate response activation."; /evidence="ECO:0000269|PubMed:33850055"; MUTAGEN 162; /note="S->D: No effect on inhibition of MAVS-mediated innate response activation."; /evidence="ECO:0000269|PubMed:33850055"; MUTAGEN 163; /note="T->D: No effect on inhibition of MAVS-mediated innate response activation."; /evidence="ECO:0000269|PubMed:33850055"; MUTAGEN 183; /note="T->D: No effect on inhibition of MAVS-mediated innate response activation."; /evidence="ECO:0000269|PubMed:33850055"; MUTAGEN 203; /note="T->D: Loss of mitochondrial translocation upon viral infection. Loss of inhibition of MAVS-mediated innate response activation."; /evidence="ECO:0000269|PubMed:33850055"; MUTAGEN 209; /note="S->D: No effect on inhibition of MAVS-mediated innate response activation."; /evidence="ECO:0000269|PubMed:33850055"; MUTAGEN 211; /note="T->D: Loss of mitochondrial translocation upon viral infection. Loss of inhibition of MAVS-mediated innate response activation."; /evidence="ECO:0000269|PubMed:33850055"; MUTAGEN 245; /note="S->D: Loss of mitochondrial translocation upon viral infection. Loss of inhibition of MAVS-mediated innate response activation."; /evidence="ECO:0000269|PubMed:33850055"; MUTAGEN 253; /note="S->D: Loss of mitochondrial translocation upon viral infection. Loss of inhibition of MAVS-mediated innate response activation."; /evidence="ECO:0000269|PubMed:33850055
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by TBK1. Phosphorylation inhibits the translocation into the mitochondrion upon Sendai viral infection. {ECO:0000269|PubMed:33850055}.
uniprot
proteins
protein_family
DDAH family
uniprot
proteins
pubmed
10384126
uniprot
proteins
pubmed
10493931
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14656967
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21493890
uniprot
proteins
pubmed
21898353
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
33850055
uniprot
proteins
pubmed
37296100
uniprot
proteins
sequence_length
285
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21898353, ECO:0000269|PubMed:33850055}. Mitochondrion {ECO:0000269|PubMed:21898353, ECO:0000269|PubMed:33850055}. Note=Translocates from cytosol to mitochondrion upon IL1B stimulation in chondrocytes.; SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:33850055}. Note=(Microbial infection) Translocates to the mitochondrion upon Sendai viral infection. {ECO:0000269|PubMed:33850055}.
uniprot
proteins