Sh3gl2
entrez
20404
canonical
uniprot
Q62420
canonical
ensembl
ENSMUSG00000028488
resolver
ensp
ENSMUSP00000030212
resolver
ensp
ENSMUSP00000231695
resolver
enst
ENSMUST00000030212
resolver
genesymbol
Sh3gl2
resolver
genesymbol_syn
Een1
resolver
genesymbol_syn
Sh3d2a
resolver
uniprot
Q3UTL7
resolver
uniprot
Q3UY49
resolver
uniprot
Q8BXS6
resolver
uniprot
Q8VBV1
resolver
uniprot_entry
SH3G2_MOUSE
resolver
uniprot_sec
Q3UTL7
resolver
uniprot_sec
Q3UY49
resolver
uniprot_sec
Q8BXS6
resolver
uniprot_sec
Q8VBV1
resolver
amino_acid_sequence
MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDMEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQPKPRMSLEFATGDSTQPNGGLSHTGTPKPPGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGQSGFFPINYVEILVALPH
uniprot
proteins
function
FUNCTION: Implicated in endocytosis (PubMed:10490020, PubMed:21849472, PubMed:29953872). Involved ultrafast endocytosis, by mediating, in a first step, neck formation and in a second step, aids in the removal of clathrin coats from the regenerated vesicles (PubMed:29953872). May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth (PubMed:21849472). Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes (PubMed:21849472). {ECO:0000269|PubMed:10490020, ECO:0000269|PubMed:21849472, ECO:0000269|PubMed:29953872}.
uniprot
proteins
mass_dalton
39955
uniprot
proteins
protein_family
Endophilin family
uniprot
proteins
pubmed
10490020
uniprot
proteins
pubmed
10531379
uniprot
proteins
pubmed
11978849
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16023669
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18602463
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19481455
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21849472
uniprot
proteins
pubmed
28891236
uniprot
proteins
pubmed
29953872
uniprot
proteins
pubmed
9630982
uniprot
proteins
sequence_length
352
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O35179}. Membrane {ECO:0000250|UniProtKB:O35179}; Peripheral membrane protein {ECO:0000250|UniProtKB:O35179}. Early endosome {ECO:0000269|PubMed:21849472}. Presynapse {ECO:0000250|UniProtKB:O35179}.
uniprot
proteins