Stx4
entrez
81803
canonical
uniprot
Q08850
canonical
ensembl
ENSRNOG00000019302
resolver
ensp
ENSRNOP00000026224
resolver
ensp
ENSRNOP00000078300
resolver
enst
ENSRNOT00000026224
resolver
enst
ENSRNOT00000095917
resolver
genesymbol
Stx4
resolver
genesymbol_syn
Stx4a
resolver
uniprot
A0A8I5XA32
resolver
uniprot
A0A8I5ZKM3
resolver
uniprot
G3V8I4
resolver
uniprot_entry
A0A8I5XA32_RAT
resolver
uniprot_entry
A0A8I5ZKM3_RAT
resolver
uniprot_entry
STX4_RAT
resolver
uniprot_sec
G3V8I4
resolver
amino_acid_sequence
MRDRTHELRQGDNISDDEDEVRVALVVHSGAARLSSPDDEFFQKVQTIRQTMAKLESKVRELEKQQVTILATPLPEESMKQGLQNLREEIKQLGREVRAQLKAIEPQKEEADENYNSVNTRMKKTQHGVLSQQFVELINKCNSMQSEYREKNVERIRRQLKITNAGMVSDEELEQMLDSGQSEVFVSNILKDTQVTRQALNEISARHSEIQQLERSIRELHEIFTFLATEVEMQGEMINRIEKNILSSADYVERGQEHVKIALENQKKARKKKVMIAICVSVTVLILAVIIGITITVG
uniprot
proteins
function
FUNCTION: Plasma membrane t-SNARE that mediates docking of transport vesicles (By similarity). Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane (By similarity). In neurons, recruited at neurite tips to membrane domains rich in the phospholipid 1-oleoyl-2-palmitoyl-PC (OPPC) which promotes neurite tip surface expression of the dopamine transporter SLC6A3/DAT by facilitating fusion of SLC6A3-containing transport vesicles with the plasma membrane (PubMed:32963038). Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes and in docking of synaptic vesicles at presynaptic active zones (By similarity). Required for normal hearing (By similarity). {ECO:0000250|UniProtKB:P70452, ECO:0000250|UniProtKB:Q12846, ECO:0000269|PubMed:32963038}.
uniprot
proteins
mass_dalton
34195
uniprot
proteins
mutagenesis
MUTAGEN 290; /note="I->F: Mislocalization in neurons from neurite tips to perinuclear region."; /evidence="ECO:0000269|PubMed:32963038
uniprot
proteins
protein_family
Syntaxin family
uniprot
proteins
pubmed
12145319
uniprot
proteins
pubmed
14993220
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
18827011
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
32963038
uniprot
proteins
pubmed
7690687
uniprot
proteins
sequence_length
298
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:32963038}; Single-pass type IV membrane protein {ECO:0000305}. Cell projection, neuron projection {ECO:0000269|PubMed:32963038}. Cell projection, stereocilium {ECO:0000250|UniProtKB:P70452}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P70452}. Note=Localizes to neurite tips in neuronal cells. {ECO:0000269|PubMed:32963038}.
uniprot
proteins
transmembrane_region
TRANSMEM 275..295; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins