Scn2b
entrez
72821
canonical
uniprot
Q56A07
canonical
ensembl
ENSMUSG00000070304
resolver
ensp
ENSMUSP00000126826
resolver
enst
ENSMUST00000170998
resolver
genesymbol
Scn2b
resolver
genesymbol_syn
Gm183
resolver
genesymbol_syn
SCN2B
resolver
uniprot
Q1MXF8
resolver
uniprot_entry
Q1MXF8_MOUSE
resolver
uniprot_entry
SCN2B_MOUSE
resolver
amino_acid_sequence
MHRDAWLPRPAFSLTGLSLFFSLVPPGRSMEVTAPTTLSVLNGSDTRLPCTFNSCYTVNHKQFSLNWTYQECNNCTEEMFLQFRMKIINLKLERFGDRVEFSGNPSKYDVSVTLKNVQLEDEGIYNCYITNPPDRHRGHGKIYLQVLLEVPPERDSTVAVIVGASVGGFLAVVILVLMVVKCVRRKKEQKLSTDDLKTEEEGKMDGEGNAEDGTK
uniprot
proteins
function
FUNCTION: Regulatory subunit of multiple voltage-gated sodium (Nav) channels directly mediating the depolarization of excitable membranes. Navs, also called VGSCs (voltage-gated sodium channels) or VDSCs (voltage-dependent sodium channels), operate by switching between closed and open conformations depending on the voltage difference across the membrane. In the open conformation they allow Na(+) ions to selectively pass through the pore, along their electrochemical gradient. The influx of Na+ ions provokes membrane depolarization, initiating the propagation of electrical signals throughout cells and tissues. The accessory beta subunits participate in localization and functional modulation of the Nav channels. Modulates the activity of SCN1A/Nav1.1, SCN2A/Nav1.2, SCN2A/Nav1.3, SCN5A/Nav1.5, SCN8A/Nav1.6, SCN9A/Nav1.7 and SCN10A/Nav1.8. {ECO:0000250|UniProtKB:O60939}.
uniprot
proteins
mass_dalton
24228
uniprot
proteins
protein_family
Sodium channel auxiliary subunit SCN2B (TC 8.A.17) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
215
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P54900}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P54900}. Cell projection, axon {ECO:0000250|UniProtKB:P54900}. Note=Clusters at the axon initial segment and node of Ranvier, the specialized neuronal subcellular domains involved in action potentials generation and propagation. {ECO:0000250|UniProtKB:P54900}.
uniprot
proteins
transmembrane_region
TRANSMEM 158..179; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O60939
uniprot
proteins