FGB
entrez
2244
canonical
uniprot
P02675
canonical
ensembl
ENSG00000171564
resolver
ensp
ENSP00000306099
resolver
ensp
ENSP00000574999
resolver
ensp
ENSP00000575001
resolver
ensp
ENSP00000575006
resolver
ensp
ENSP00000655022
resolver
ensp
ENSP00000655053
resolver
ensp
ENSP00000655061
resolver
ensp
ENSP00000789121
resolver
enst
ENST00000302068
resolver
genesymbol
FGB
resolver
genesymbol
HEL-S-78p
resolver
genesymbol_syn
FGB
resolver
hgnc
HGNC:3662
resolver
uniprot
A0JLR9
resolver
uniprot
B2R7G3
resolver
uniprot
Q32Q65
resolver
uniprot
Q3KPF2
resolver
uniprot
V9HVY1
resolver
uniprot_entry
FIBB_HUMAN
resolver
uniprot_entry
V9HVY1_HUMAN
resolver
uniprot_sec
A0JLR9
resolver
uniprot_sec
B2R7G3
resolver
uniprot_sec
Q32Q65
resolver
uniprot_sec
Q3KPF2
resolver
amino_acid_sequence
MKRMVSWSFHKLKTMKHLLLLLLCVFLVKSQGVNDNEEGFFSARGHRPLDKKREEAPSLRPAPPPISGGGYRARPAKAAATQKKVERKAPDAGGCLHADPDLGVLCPTGCQLQEALLQQERPIRNSVDELNNNVEAVSQTSSSSFQYMYLLKDLWQKRQKQVKDNENVVNEYSSELEKHQLYIDETVNSNIPTNLRVLRSILENLRSKIQKLESDVSAQMEYCRTPCTVSCNIPVVSGKECEEIIRKGGETSEMYLIQPDSSVKPYRVYCDMNTENGGWTVIQNRQDGSVDFGRKWDPYKQGFGNVATNTDGKNYCGLPGEYWLGNDKISQLTRMGPTELLIEMEDWKGDKVKAHYGGFTVQNEANKYQISVNKYRGTAGNALMDGASQLMGENRTMTIHNGMFFSTYDRDNDGWLTSDPRKQCSKEDGGGWWYNRCHAANPNGRYYWGGQYTWDMAKHGTDDGVVWMNWKGSWYSMRKMSMKIRPFFPQQ
uniprot
proteins
disease_involvement
DISEASE: Congenital afibrinogenemia (CAFBN) [MIM:202400]: Rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. {ECO:0000269|PubMed:10666208, ECO:0000269|PubMed:11468164, ECO:0000269|PubMed:15070683, ECO:0000269|PubMed:25427968}. Note=The disease is caused by variants affecting the gene represented in this entry. Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding.; DISEASE: Dysfibrinogenemia, congenital (DYSFIBRIN) [MIM:616004]: A disorder characterized by qualitative abnormalities (dysfibrinogenemia) of the circulating fibrinogen. Affected individuals are frequently asymptomatic, but some patients have bleeding diathesis, thromboembolic complications, or both. In some cases, dysfibrinogenemia is associated with low circulating fibrinogen levels (hypodysfibrinogenemia). {ECO:0000269|PubMed:1634610}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. {ECO:0000250|UniProtKB:E9PV24}.
uniprot
proteins
mass_dalton
55928
uniprot
proteins
post_translational_modification
PTM: Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers. {ECO:0000269|PubMed:2143188}.
uniprot
proteins
pubmed
10074346
uniprot
proteins
pubmed
10391209
uniprot
proteins
pubmed
10666208
uniprot
proteins
pubmed
11468164
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15070683
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1565641
uniprot
proteins
pubmed
16263699
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
1634610
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19296670
uniprot
proteins
pubmed
2018836
uniprot
proteins
pubmed
2102623
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2143188
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25427968
uniprot
proteins
pubmed
3029722
uniprot
proteins
pubmed
3156856
uniprot
proteins
pubmed
3194892
uniprot
proteins
pubmed
420779
uniprot
proteins
pubmed
6383194
uniprot
proteins
pubmed
6575689
uniprot
proteins
pubmed
6575700
uniprot
proteins
pubmed
6688356
uniprot
proteins
pubmed
7642629
uniprot
proteins
pubmed
891553
uniprot
proteins
pubmed
9333233
uniprot
proteins
pubmed
936108
uniprot
proteins
pubmed
9628725
uniprot
proteins
sequence_length
491
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10074346, ECO:0000269|PubMed:19296670, ECO:0000269|PubMed:9628725}.
uniprot
proteins