Fbxo10
entrez
269529
canonical
uniprot
Q7TQF2
canonical
ensembl
ENSMUSG00000048232
resolver
ensp
ENSMUSP00000058233
resolver
ensp
ENSMUSP00000119862
resolver
ensp
ENSMUSP00000261372
resolver
enst
ENSMUST00000052236
resolver
genesymbol
Fbxo10
resolver
genesymbol_syn
Gm634
resolver
uniprot
A2ANI6
resolver
uniprot
Q6AXG0
resolver
uniprot
Q7TQM0
resolver
uniprot_entry
FBX10_MOUSE
resolver
uniprot_sec
A2ANI6
resolver
uniprot_sec
Q6AXG0
resolver
uniprot_sec
Q7TQM0
resolver
amino_acid_sequence
METGGLPLELWRMILAYLHLPDLGRCSLVCRAWYELILSLDSTRWRQLCLGCTECRHPNWPNQPDVEPESWREAFKQHYLASKTWTKNALDLESSICFSLFRRKKERRTLSVGPGHEFDSLGSALAMASLYDRIVLFPGVYEEQGEIILKVPVEIVGQGKLGEVALLASIDQHCSTTRVCNLVFMPAWFSPIMYKTTSGHIQFDNCNFENGHIQVHGPGTCQVKFCTFKNTHVFLHNVPLCMLENCEFVGSENNCVTVEGHPSADKNWAYKYLLGLIKSSPIFLPAEDHDFLMSLDLESRDQAWSPRTCDIVIEGSQSPTSPVCSSPKPGSKEAEVGSDGERVAQTPDSSDGGLSPSGEDEDDEQLTYRLSYQVQGPRPVLGGSFLGPPLPGASIQLPSCLVLNSLHQELQKDKEAMALASSVQGCLIRKCLFRDGKGGVFVCSYGRAKMEGNVFRNLTYAVRCIHNSKIVMLRNDIYRCRASGIFLRLEGGGLIAGNNIYHNAEAGVDIRKKSNPLILCNQIHHGLRSGIVVLGNGKGVIRNNQIFSNKEAGIYILYHGNPIVSGNHIFKGRAAGIAVNENGKGLITENVIRENQWGGVDIRRGGVPILRSNLICFGYSDGVVVGDEGKGLIEGNTIYANKGCGVWMMSSSLPHVTSNHVSYNGLYGVAVFSQKDGEFPGGHGAQENFSEDGDAILWEAELEKEDDPLRRPITVALVESNSINHNGASGIFVQSSEALQVVANVIHANGDRGITIVQSSQLTRVANNSISCNRQSGVKVEFQCKVELRGNGIYDNRGHGIITKGDGTAVVENDIIGNRGSGLQLLPRSDTKVLKNRIHSFRAYGIAVRGRVKALVQENIIFQGKTNKTIFQQITNNRECIMQNNKFLVFKKKSDTWRLVNPPARPHLENSLRGSSAAHSGHKVTAMATRITARVEGGYHSNRSIFCTIL
uniprot
proteins
function
FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2. Targets also the receptor for advanced glycation end products RAGE for ubiquitination and subsequent lysosomal degradation. Directly controls HGAL/GCSAM ubiquitination and degradation and thereby decreases BCR signaling. {ECO:0000250|UniProtKB:Q9UK96}.
uniprot
proteins
mass_dalton
104478
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
33914737
uniprot
proteins
sequence_length
950
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UK96}.
uniprot
proteins