Ankrd16
entrez
320816
canonical
uniprot
A2AS55
canonical
ensembl
ENSMUSG00000047909
resolver
ensp
ENSMUSP00000052056
resolver
ensp
ENSMUSP00000251134
resolver
ensp
ENSMUSP00000251165
resolver
genesymbol
Ankrd16
resolver
uniprot
Q8BH84
resolver
uniprot_entry
ANR16_MOUSE
resolver
uniprot_sec
Q8BH84
resolver
amino_acid_sequence
MALPGDPRRLCRLVQEGRLRDLQEELAVARGCRGPAGDTLLHCAARHGRQDILAYLVEAWSMDIEATNRDYKRPLHEAASMGHRDCVRYLLGRGAVVDSLKKADWTPLMMACTRKNLDVIQDLVEHGANPLLKNKDGWNSFHIASREGHPVILRYLLTVCPDAWKTESNIRRTPLHTAAMHGCLEAVQVLLERCHYEPDCRDNCGVTPFMDAIQCGHVSIAKLLLEQHKACSSAADSMGAQALHRAAVTGQDEAIRFLVCGLGIDVDVRAKSSQLTALHYAAKEGQTNTVQTLLSLGADINSTDERNRSVLHLACAGQHVACTRLLLQSGLKDSEDLTGTLAQQLTRSVDILQDFDHDVKS
uniprot
proteins
function
FUNCTION: Required to prevent the misactivation of serine (Ser) with tRNA(Ala) by promoting the hydrolysis of Ser-mischarged tRNA(Ala), thereby playing a role in translational fidelity (PubMed:29769718). Binds directly to the catalytic domain of AARS/AlaRS and captures Ser that is misactivated by AARS/AlaRS, preventing the charging of Ser adenylates to tRNA(Ala) and precluding Ser misincorporation in nascent peptides (PubMed:29769718). {ECO:0000269|PubMed:29769718}.
uniprot
proteins
mass_dalton
39776
uniprot
proteins
mutagenesis
MUTAGEN 102; /note="K->R: In ANKRD16(3XR); abolished ability to enhance hydrolysis of Ser-mischarged tRNA(Ala); when associated with R-135 and R-165."; /evidence="ECO:0000269|PubMed:29769718"; MUTAGEN 135; /note="K->R: In ANKRD16(3XR); abolished ability to enhance hydrolysis of Ser-mischarged tRNA(Ala); when associated with R-102 and R-165."; /evidence="ECO:0000269|PubMed:29769718"; MUTAGEN 165; /note="K->R: In ANKRD16(3XR); abolished ability to enhance hydrolysis of Ser-mischarged tRNA(Ala); when associated with R-102 and R-135."; /evidence="ECO:0000269|PubMed:29769718
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
29769718
uniprot
proteins
sequence_length
361
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:29769718}. Nucleus {ECO:0000269|PubMed:29769718}.
uniprot
proteins