DSC1
entrez
1823
canonical
uniprot
Q08554
canonical
ensembl
ENSG00000134765
resolver
ensp
ENSP00000257197
resolver
ensp
ENSP00000257198
resolver
genesymbol
DSC1
resolver
genesymbol_syn
CDHF1
resolver
hgnc
HGNC:3035
resolver
uniprot
Q9HB00
resolver
uniprot
Q9HB01
resolver
uniprot_entry
DSC1_HUMAN
resolver
uniprot_entry
Q9HB00_HUMAN
resolver
uniprot_sec
Q9HB01
resolver
amino_acid_sequence
MALASAAPGSIFCKQLLFSLLVLTLLCDACQKVYLRVPSHLQAETLVGKVNLEECLKSASLIRSSDPAFRILEDGSIYTTHDLILSSERKSFSIFLSDGQRREQQEIKVVLSARENKSPKKRHTKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKEPFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAPYFEHRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDTGVITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEVEENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNYEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGFPAGQELLGYKALDPEISSGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKNNQYNISVVAVDAVGRSCTGTLVVHLDDYNDHAPQIDKEVTICQNNEDFAVLKPVDPDGPENGPPFQFFLDNSASKNWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKDRHGLVATHMLTVRVCDCSTPSECRMKDKSTRDVRPNVILGRWAILAMVLGSVLLLCILFTCFCVTAKRTVKKCFPEDIAQQNLIVSNTEGPGEEVTEANIRLPMQTSNICDTSMSVGTVGGQGIKTQQSFEMVKGGYTLDSNKGGGHQTLESVKGVGQGDTGRYAYTDWQSFTQPRLGEKVYLCGQDEEHKHCEDYVCSYNYEGKGSLAGSVGCCSDRQEEEGLEFLDHLEPKFRTLAKTCIKK
uniprot
proteins
function
FUNCTION: A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (By similarity). Required for desmosome adhesion strength between the granular layers of the epidermis, as a result moderates epidermal proliferation and differentiation (By similarity). Is therefore required to maintain postnatal epidermal barrier function and normal hair follicle morphology into adulthood (By similarity). {ECO:0000250|UniProtKB:P55849}.
uniprot
proteins
mass_dalton
99987
uniprot
proteins
pubmed
11027496
uniprot
proteins
pubmed
1713860
uniprot
proteins
pubmed
17487921
uniprot
proteins
pubmed
19136012
uniprot
proteins
pubmed
19759396
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
8288219
uniprot
proteins
pubmed
8507556
uniprot
proteins
sequence_length
894
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1713860}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, desmosome {ECO:0000250|UniProtKB:P55849}.
uniprot
proteins
transmembrane_region
TRANSMEM 692..714; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins