SMURF1
entrez
57154
canonical
uniprot
Q9HCE7
canonical
ensembl
ENSG00000198742
resolver
ensp
ENSP00000354621
resolver
ensp
ENSP00000355326
resolver
ensp
ENSP00000555347
resolver
ensp
ENSP00000555348
resolver
genesymbol
SMURF1
resolver
genesymbol_syn
KIAA1625
resolver
hgnc
HGNC:16807
resolver
uniprot
A4D279
resolver
uniprot
B7ZMB6
resolver
uniprot
B9EGV3
resolver
uniprot
O75853
resolver
uniprot
Q547Q3
resolver
uniprot
Q9UJT8
resolver
uniprot_entry
SMUF1_HUMAN
resolver
uniprot_sec
A4D279
resolver
uniprot_sec
B7ZMB6
resolver
uniprot_sec
B9EGV3
resolver
uniprot_sec
O75853
resolver
uniprot_sec
Q547Q3
resolver
uniprot_sec
Q9UJT8
resolver
amino_acid_sequence
MSNPGTRRNGSSIKIRLTVLCAKNLAKKDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKTDSITISVWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPSDTDAVRGQIVVSLQTRDRIGTGGSVVDCRGLLENEGTVYEDSGPGRPLSCFMEEPAPYTDSTGAAAGGGNCRFVESPSQDQRLQAQRLRNPDVRGSLQTPQNRPHGHQSPELPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPSPSGTIPGGDAAFLYEFLLQGHTSEPRDLNSVNCDELGPLPPGWEVRSTVSGRIYFVDHNNRTTQFTDPRLHHIMNHQCQLKEPSQPLPLPSEGSLEDEELPAQRYERDLVQKLKVLRHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITPVLDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKHCVADSNIVRWFWQAVETFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAVE
uniprot
proteins
ec_number
2.3.2.26
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of SMAD1 and SMAD5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and RHOA. Promotes ubiquitination and subsequent proteasomal degradation of MAVS (PubMed:23087404). Acts as a positive regulator of smoothened signaling pathway by mediating ubiquitination of PTCH1, leading to endocytosis and lysosomal degradation of PTCH1 (By similarity). Acts as an antagonist of TGF-beta signaling by ubiquitinating TGFBR1 and targeting it for degradation (PubMed:21791611). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250|UniProtKB:Q9CUN6, ECO:0000269|PubMed:10458166, ECO:0000269|PubMed:19937093, ECO:0000269|PubMed:21402695, ECO:0000269|PubMed:21791611, ECO:0000269|PubMed:23087404, ECO:0000269|PubMed:23999003}.
uniprot
proteins
mass_dalton
86114
uniprot
proteins
mutagenesis
MUTAGEN 28; /note="K->A: Fails to ubiquitinate RHOA; when associated with A-85."; /evidence="ECO:0000269|PubMed:21402695"; MUTAGEN 85; /note="K->A: Fails to ubiquitinate RHOA; when associated with A-28."; /evidence="ECO:0000269|PubMed:21402695"; MUTAGEN 350; /note="K->R: Abolishes FBXL15-mediated ubiquitination and degradation; when associated with R-381 and R-381."; /evidence="ECO:0000269|PubMed:21572392"; MUTAGEN 381; /note="K->R: Abolishes FBXL15-mediated ubiquitination and degradation; when associated with R-350 and R-383. Abolishes FBXL15-mediated ubiquitination and degradation; when associated with R-383."; /evidence="ECO:0000269|PubMed:21572392"; MUTAGEN 383; /note="K->R: Abolishes FBXL15-mediated ubiquitination and degradation; when associated with R-350 and R-381. Abolishes FBXL15-mediated ubiquitination and degradation; when associated with R-381."; /evidence="ECO:0000269|PubMed:21572392"; MUTAGEN 725; /note="C->A: Loss of enzyme activity, without abolishing FBXL15-mediated ubiquitination."; /evidence="ECO:0000269|PubMed:19937093, ECO:0000269|PubMed:21572392
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:19937093}.
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated in presence of NDFIP1 (PubMed:23087404). Ubiquitinated by the SCF(FBXL15) complex at Lys-381 and Lys-383, leading to its degradation by the proteasome. Lys-383 is the primary ubiquitination site. {ECO:0000269|PubMed:21572392, ECO:0000269|PubMed:23087404}.
uniprot
proteins
pubmed
10458166
uniprot
proteins
pubmed
10997877
uniprot
proteins
pubmed
11163210
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19937093
uniprot
proteins
pubmed
21402695
uniprot
proteins
pubmed
21572392
uniprot
proteins
pubmed
21791611
uniprot
proteins
pubmed
23087404
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23999003
uniprot
proteins
sequence_length
757
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21572392}. Cell membrane {ECO:0000269|PubMed:21572392}; Peripheral membrane protein {ECO:0000269|PubMed:21572392}; Cytoplasmic side {ECO:0000269|PubMed:21572392}.
uniprot
proteins