Fbxo6
entrez
192351
canonical
uniprot
Q923V4
canonical
ensembl
ENSRNOG00000009217
resolver
ensembl
ENSRNOG00060029786
resolver
ensp
ENSRNOP00000012301
resolver
ensp
ENSRNOP00060043002
resolver
enst
ENSRNOT00000012301
resolver
enst
ENSRNOT00060051730
resolver
genesymbol
Fbxo6
resolver
genesymbol_syn
Fbg2
resolver
genesymbol_syn
Fbs2
resolver
genesymbol_syn
Fbxo6b
resolver
uniprot
Q6P512
resolver
uniprot_entry
FBX6_RAT
resolver
uniprot_sec
Q6P512
resolver
amino_acid_sequence
MVNINELPENILLELFTHVPAPQLLRNCRLVCSLWRDLIDVMTLWKRKSLREGFVTKDRDEPVDDWKIFYILCSLQRNLLRNPCAEENLRSWRIDSNGGDEWKVESLPGDHGTSFPDTKVKKYFVTSYGMCLKSQMVDLKAEGYSEKLLDTVRPDIVVKDWFAPRADCGCTYHLRVQLASADYIVLASFEPPPVTIEQWNDASWQEISHTFSNYPPGVRHILFQHGGKDTQFWKGWYGPRVTNSSIIVSHRTAKNPAPARTLPEEDTSNRRKILSFGSWEDLSP
uniprot
proteins
function
FUNCTION: Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to ensure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
32786
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
12383498
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
284
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins