Arhgef25
entrez
52666
canonical
uniprot
Q9CWR0
canonical
ensembl
ENSMUSG00000019467
resolver
ensp
ENSMUSP00000019611
resolver
ensp
ENSMUSP00000126339
resolver
ensp
ENSMUSP00000151325
resolver
ensp
ENSMUSP00000161515
resolver
enst
ENSMUST00000019611
resolver
enst
ENSMUST00000167353
resolver
enst
ENSMUST00000218654
resolver
genesymbol
Arhgef25
resolver
genesymbol_syn
D10Ertd610e
resolver
genesymbol_syn
Geft
resolver
uniprot
A0A0R4J211
resolver
uniprot
A0A1W2P6R9
resolver
uniprot
G5E825
resolver
uniprot
Q3TYF3
resolver
uniprot
Q8R1Q4
resolver
uniprot_entry
A0A0R4J211_MOUSE
resolver
uniprot_entry
A0A1W2P6R9_MOUSE
resolver
uniprot_entry
ARHGP_MOUSE
resolver
uniprot_entry
G5E825_MOUSE
resolver
uniprot_sec
Q3TYF3
resolver
uniprot_sec
Q8R1Q4
resolver
amino_acid_sequence
MKPPDRPTPGRTDRILGVMGGMLRACAVPGQEGPPERDPLGPGSTKTESDCIEEDQTGQREPEVLAWAPQPESYSIAVSEGSMSASAVSGLAALSGPSSGLSSDPCSPIPPGPVTGLRRWLDHSKHCLSVETEAESGQTGQCENWTLGPTLTTGQELPELTLLTTLLEGPGDKAQPAEEETLSQAPKNEEEQKKMALERSMFVLGELVETERTYEDDLGQIVEGYMATMATQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQQCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVLSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYRRAGKDTEELEQAVEVMCFVPKRCNDMMSLGRLRGFEGKLTAQGKLLGQDTFLVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALGGGGRGGAQPGYVYKNSIKVSCLGLEGNLQGNPCRFALTSRGPEGGIQRYVLQASDPAVSQAWIKQVAQILESQRDFLNALQSPIEYQRRESQTNSLGRPGGPWVGSPGRMRPGDLAQASMHTPINGSLPSLLLLPRGEVSRVLLPLDTQALSDTPQTPHDSPALPTVNTPPCQARLAKLDEDEL
uniprot
proteins
function
FUNCTION: May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation (By similarity). May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis. {ECO:0000250, ECO:0000269|PubMed:15322108, ECO:0000269|PubMed:16314529, ECO:0000269|PubMed:16496360}.
uniprot
proteins
mass_dalton
68262
uniprot
proteins
pubmed
12547822
uniprot
proteins
pubmed
15322108
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16314529
uniprot
proteins
pubmed
16496360
uniprot
proteins
pubmed
18541910
uniprot
proteins
sequence_length
618
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere {ECO:0000250}. Cell membrane {ECO:0000269|PubMed:18541910}. Cytoplasm, myofibril {ECO:0000269|PubMed:18541910}. Note=Highly colocalizes with actin regions. {ECO:0000250}.
uniprot
proteins