Foxa1
entrez
25098
canonical
uniprot
P23512
canonical
ensembl
ENSRNOG00000009284
resolver
ensp
ENSRNOP00000009940
resolver
ensp
ENSRNOP00000090884
resolver
enst
ENSRNOT00000009940
resolver
enst
ENSRNOT00000119772
resolver
genesymbol
Foxa1
resolver
genesymbol_syn
Hnf3a
resolver
genesymbol_syn
Tcf-3a
resolver
genesymbol_syn
Tcf3a
resolver
uniprot
A0A8I6AF62
resolver
uniprot
F1LR25
resolver
uniprot_entry
A0A8I6AF62_RAT
resolver
uniprot_entry
F1LR25_RAT
resolver
uniprot_entry
FOXA1_RAT
resolver
amino_acid_sequence
MLGTVKMEGHESNDWNSYYADTQEAYSSVPVSNMNSGLGSMNSMNTYMTMNTMTTSGNMTPASFNMSYANPGLGAGLSPGAVAGMPGGSAGAMNSMTAAGVTAMGAALSPGGMGSMGAQPAASMNGLGPYAAAMNPCMSPMAYAPSNLGRSRAGGGGDAKTFKRSYPHAKPPYSYISLITMAIQQAPSKMLTLSEIYQWIMDLFPYYRQNQQRWQNSIRHSLSFNACFVKVARSPDKPGKGSYWTLHPDSGNMFENGCYLRRQKRFKCEKQPGAGGGSGGGGSKGVPENRKDPSGPVNPSAESPIHRGVHGKASQLEGAPAPGPAASPQTLDHSGATATGGGSELKSPASSSAPPISSGPGGWICTPLSPTWLAPHESQLHLKGAPHYSFNHPFSINNLMSSSEQQHKLDFKAYEQALQYSPYGATLPASLPLGGASVATRSPIEPSALEPAYYQGVYSRPVLNTS
uniprot
proteins
function
FUNCTION: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3'. Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Involved in glucose homeostasis; activates the GCG promoter. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas, lungs and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles. Modulates the transcriptional activity of nuclear hormone receptors. Is required for maximal gene activation mediated by AR in the prostate. Negatively regulates AR transactivation via competition with coactivators such as NCOA2. Is involved in ESR1-mediated transcription. Involved in regulation of apoptosis. Involved in cell cycle regulation. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. {ECO:0000269|PubMed:12750453, ECO:0000269|PubMed:15358835, ECO:0000269|PubMed:17220277, ECO:0000269|PubMed:18178153}.
uniprot
proteins
mass_dalton
48775
uniprot
proteins
pubmed
12750453
uniprot
proteins
pubmed
15358835
uniprot
proteins
pubmed
17189638
uniprot
proteins
pubmed
17220277
uniprot
proteins
pubmed
18178153
uniprot
proteins
pubmed
2227418
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
466
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins