BTF3
entrez
689
canonical
uniprot
P20290
canonical
ensembl
ENSG00000145741
resolver
ensp
ENSP00000338516
resolver
ensp
ENSP00000369965
resolver
ensp
ENSP00000503967
resolver
ensp
ENSP00000772536
resolver
genesymbol
BTF3
resolver
genesymbol_syn
NACB
resolver
hgnc
HGNC:1125
resolver
uniprot
A8K510
resolver
uniprot
Q13893
resolver
uniprot
Q76M56
resolver
uniprot_entry
BTF3_HUMAN
resolver
uniprot_sec
A8K510
resolver
uniprot_sec
Q13893
resolver
uniprot_sec
Q76M56
resolver
amino_acid_sequence
MRRTGAPAQADSRGRGRARGGCPGGEATLSQPPPRGGTRGQEPQMKETIMNQEKLAKLQAQVRIGGKGTARRKKKVVHRTATADDKKLQFSLKKLGVNNISGIEEVNMFTNQGTVIHFNNPKVQASLAANTFTITGHAETKQLTEMLPSILNQLGADSLTSLRRLAEALPKQSVDGKAPLATGEDDDDEVPDLVENFDEASKNEAN
uniprot
proteins
function
FUNCTION: When associated with NACA, prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. BTF3 is also a general transcription factor that can form a stable complex with RNA polymerase II. Required for the initiation of transcription. {ECO:0000269|PubMed:10982809}.
uniprot
proteins
mass_dalton
22168
uniprot
proteins
protein_family
NAC-beta family
uniprot
proteins
pubmed
10982809
uniprot
proteins
pubmed
1386332
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
21203952
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2320128
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
206
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10982809}. Nucleus {ECO:0000269|PubMed:10982809}. Note=The heterodimer with NACA is cytoplasmic.
uniprot
proteins