Retreg2
entrez
227298
canonical
uniprot
Q6NS82
canonical
ensembl
ENSMUSG00000049339
resolver
ensp
ENSMUSP00000095300
resolver
ensp
ENSMUSP00000139410
resolver
genesymbol
Retreg2
resolver
genesymbol_syn
Fam134a
resolver
uniprot
Q3TA48
resolver
uniprot
Q3TMF7
resolver
uniprot
Q8BSD3
resolver
uniprot
Q8CHY1
resolver
uniprot
Q8R0Q3
resolver
uniprot_entry
RETR2_MOUSE
resolver
uniprot_sec
Q3TA48
resolver
uniprot_sec
Q3TMF7
resolver
uniprot_sec
Q8BSD3
resolver
uniprot_sec
Q8CHY1
resolver
uniprot_sec
Q8R0Q3
resolver
amino_acid_sequence
MASSGGGNTGAGGTSGLGLGLGLSLGMGEATGDAEEEAAAAEAVGRLATSLWLRLRGWEAVLAAAQRLLVWEKPLHSLVTAATLNGLFWLLSSSSLRPFFLLSISLLTYFLLDLWHPRFLPDVSAPPPEEPHSDSEGAGSGAQPHLLSVPELCRYLAESWLTFQIHLQELLQYKRQNPAQFCARGCAACAVLAVLGHYVPGVMISYIVLLSILLWPLVVYHELIQRMYTRLEPLLMQLDYSMKAEADALHHKHDKRKRQGKSAPPAGDEPLAETESESEAELAGFSPVVDVKKTALALAITDSELSDEEASILESGGFSVSRATTPQLTDVSEDLDQQSLPSEPEEALNRELGEGEETELASPEDLLSAPPALSKQALDTEEEGAADKEALLQLSSPLHFVNTHFNGAGSPQDGVKCPPGAPVKTLSPEAVSGDLMAPSSTLSPQLCLAESGPVTPLSPSVLPSLPQDSPQPLAAPEEEEALTTEDFELLDQGELEQLNAELGLGPEMPPKPPDVLPPPPLGADSHSLVQSDQEAHAEVEP
uniprot
proteins
function
FUNCTION: Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Required for collagen quality control in a LIR motif-independent manner (PubMed:34338405). {ECO:0000269|PubMed:34338405}.
uniprot
proteins
mass_dalton
57542
uniprot
proteins
mutagenesis
MUTAGEN 487..490; /note="FELL->AELA: Abolishes interaction with ATG8 family proteins. Does not affect collagen degradation."; /evidence="ECO:0000269|PubMed:34338405
uniprot
proteins
protein_family
RETREG family
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19838196
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
34338405
uniprot
proteins
sequence_length
541
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8NC44}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..30; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 87..107; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 199..219; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins