Aspm
entrez
12316
canonical
uniprot
Q8CJ27
canonical
ensembl
ENSMUSG00000033952
resolver
ensp
ENSMUSP00000059159
resolver
genesymbol
Aspm
resolver
genesymbol_syn
Calmbp1
resolver
genesymbol_syn
Sha1
resolver
uniprot
A0A0G2JES1
resolver
uniprot
B1ARM7
resolver
uniprot
O88482
resolver
uniprot
Q4G1G9
resolver
uniprot
Q8BJI8
resolver
uniprot
Q8BKT4
resolver
uniprot_entry
ASPM_MOUSE
resolver
uniprot_sec
A0A0G2JES1
resolver
uniprot_sec
B1ARM7
resolver
uniprot_sec
O88482
resolver
uniprot_sec
Q4G1G9
resolver
uniprot_sec
Q8BJI8
resolver
uniprot_sec
Q8BKT4
resolver
amino_acid_sequence
MATMQAASCPEERGRRARPDPEAGDPSPPVLLLSHFCGVPFLCFGDVRVGTSRTRSLVLHNPHEEPLQVELSLLRAAGQGFSVAPNRCELKPKEKLTISVTWTPLREGGVREIVTFLVNDFLKHQAILLGNAEEPKKKKRSLWNTSKKIPASSKHTKRTSKNQHFNESFTISQKDRIRSPLQPCENLAMSECSSPTENKVPTPSISPIRECQSETCLPLFLRESTAYSSLHESENTQNLKVQDASISQTFDFNEEVANETFINPISVCHQSEGDRKLTLAPNCSSPLNSTQTQIHFLSPDSFVNNRYTSDNDLKSMKNVLSDTFRKDPAESVCLESQTVHEVCQTILSPDSFLNDNYGLKKGLNFKSVNPVLSPTQFVKDSMGHVGQQTGKSNEASQDWRINEGLAYTPECQHAQTPSSRSEKQNPVEVKPHTYDFTKQKPKISEFQDAFCHQSKQPHKRRPILSATVTKRKPTNAREKLPEINKPDAKRCLEGLVGERGKEVGSLREKGFHSSLPVVEPGVSKALSYRDEVTPATVVVARKRKSHGTVGDANGKVAAEEWMDMCEVKRIHFSPLESTPSTVARTTKKEGHTSKRISSLERSGLKKKMDSSILKTPLSKTKKKRRSIVAVAQSHLTFIKPLKAAIPRHPMPFAAKNMFYDERWKEKQEQGFTWWLNYILTPDDFTVKTNVSKVNAASLVLGAESQHKISVPKAPTKEEVSLRAYTASCRLNRLRRTACSLFTSEKMVKAIKKVEIEIEVGRLLVRKDRHLWKDIGQRQKVLNWLLSYNPLWLRIGLETVFGELIPLADNSDVTGLAMFILNRLLWNPDIAAEYRHPTVPLLFRDGHEAALSKFTLKKLLLLICFLDHAKISRLIDHDPCLFCKDAEFKASKELLLAFSRDFLSGEGDLSRHLSFLGLPVSHVQTPLDEFDFAVTNLAVDLQCGVRLVRTVELLTQNWNLSDKLRIPAISRVQKMHNVDLVLQVLKSRGVPLTDEHGSAISSKDVVDRHREKTLGLLWKIALAFQVDISLNLDQLKEEIDFLKHTHSIKRAMSALTCPSQAITNKQRDKRISGNFERYGDSVQLLMDWVNAVCAFYNKKVENFTVSFSDGRILCYLIHHYHPCYVPFDAICQRTSQSVACAQTGSVVLNSSSESEGGCLDLSLEALDHESTPEMYKELLENEKKNFHLVRSAARDLGGIPAMIHHSDMSNTIPDEKVVITYLSFLCARLLDLRKEIRAARLIQTTWRKYKLKRDLKHHQERDKAARVIQSVVLNFLSRRRLQKNVSAALVIQKCWRRVSAQRKLRMLKNEKLAKLQNKSAVLIQAYWRRYSTRKRFLRLKHYSVILQSRIRMKIALTSYKRYLWATVTIQRHWRAYLSRKRDQQIFRKLKSSSLVIQFMFRRWKRRKLQLQTKAAVTLQRAFREWHLRKQIRERSAVVIQSWYRMHRELQKYIYIRSCVIVIQRRVRCFQAQKLYKRRKDAILTLQKHYRARQKGKLAHADYLQKRAATIRLQAAFRGMKARHSYRLQIGAACVLQSYWRMRQERVRFLNLKKMVIKLQAHIRKYQQLQKYKKIKKAAITIQTHFRASISARRVLASYQKTRSSVIVLQSACRGMQARKAFRHALASVIKIQSYYRAYICRKTFQNFKNATIKLQSIVKMKQSRKQYLQIRAAALFIQRWYRSQKLASQKRKEYIQVRESCIKLQSHFRGCLVRKQLRLQCKAAISLQSYFRMRTARQRYLKMCKAALVIQSFYCAYRAQISQRKNFLQVKRAAICLQAAYRGCKVRRQIKQQSTAAVTIQRVFRGHSQRMKYQTMLQSAVKIQRWYRAQKVAYDMRIQFLKTREAVVCLQSAYRGWQVRQQLRRQHEAAVKIQSTFRMAVAQQQYKLLRAAAAVIQQHVRARAAGKRQHLAYIQLRHAALVFQAAWKGKMLRRQIARQHQCAALIQSYYRMHIQRRKWSIMKTAALQIQLCYRAYKVGKEQRHLYLKTKAAVVTLQSAYRGMKVRKRVAECHKAAVTIQSKFRAYRTQKKYTTYRTSAIVIQRWYRNIKITTQQHQEYLNLRRAAVQVQAAYRGIRVRRRIQHMHMAATLIEAMFKMRQSRVRYLKMRTAALIIQVRYRAYYLGKIQHEKYLRTLKAIKTLQAGVRGARVRRTVRKMHFAATLIQSHFRGHRQQTYFHRLRKAATMVQQRYRAVKEGSAEFQRYSRLRRSVLLIQAAFRGLRTRRHLKAMHLAATLIQRRFRTFAMRRKFLSLRKTAIWIQRQYRARLYAKYSRQQLLLEKAVIKIQSSYRGWVVRKRVQKMHRAATVIQATFRMHGAYMRYQHLKRASVVIQVHTAAELQRQKHAAVILQAAVRGMKTRSHLKTMHSSATLIQSQFRAFIVRRRFIALRKAAIFVQRKFRATLYAKHKLHQFLQLRKAAITIQSSYRRLMVQKKLQEMHRAAALIQATFRMHRTYVAFHIWKCASIRIQQCYRTYRTIKLQKEKLIREEQHSAAVLIQSTYRMYRQRCFYQQRRWAAKVIQKTYRANKRRQDLLYVCKEETPLLQMHFQGLNTAKQGRQQHGAAMITQKHFRAFKARRLMEAERGFQAGCRKYKAKKYLSKVEAACRIQAWYRRWRAHKKYLTLLKAVNIIEGYLSAQLARRRFLKMRAAAIIIQRKWRATLSVRGARENLKRHRAACVIQAHFRGYQARQSFLQQRSAVLIIQRHVRAMVAAKQERIKYIKLKKSTVVVQALVRGWLVRKRVSEQKAKTRLFHFTAAAYCHMCALKIQRAYRLHVTLRNAKKHMDSVIFIQRWFRKRLQRKRFIEQYHKILSTRREAHACWLQQDRAASVIQKAVRRFLLCRRQEKITSCATRIQALWRGYSWRKKNDHTEIKAIRRSLRAVSTTVEEENKLYRRTERALHHLLTYKHLSAILDALKHLEVVTRLSPLCCENMAESGAVSTIFVVIRSCNRSVPCMEVVGYAVQVLLNVAKYDKTIAAVYEAENCVDTLLELLQVYREKPGDRVAEKSASIFTRTCCLLAVLLKTEQCAFDAQSRSKVTDRIYRLYKFTVPKHKVNTQGLFDKQKQNSCVGFPCIPERTMKTRLVSRLKPQWVLRRDNVEEITNSLQAIQLVMDTLGISY
uniprot
proteins
function
FUNCTION: Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seem to depend on its association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis. {ECO:0000269|PubMed:12355089, ECO:0000269|PubMed:28436967, ECO:0000269|PubMed:9819352}.
uniprot
proteins
mass_dalton
364218
uniprot
proteins
mutagenesis
MUTAGEN 302; /note="F->A: Disrupts interaction with KATNA1:KATNB1; when associated with A-377."; /evidence="ECO:0000269|PubMed:28436967"; MUTAGEN 352; /note="F->A: Disrupts interaction with KATNA1:KATNB1."; /evidence="ECO:0000269|PubMed:28436967"; MUTAGEN 377; /note="F->A: Disrupts interaction with KATNA1:KATNB1; when associated with A-302."; /evidence="ECO:0000269|PubMed:28436967
uniprot
proteins
pubmed
12351193
uniprot
proteins
pubmed
12355089
uniprot
proteins
pubmed
15972725
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
28436967
uniprot
proteins
pubmed
9819352
uniprot
proteins
sequence_length
3122
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9819352}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:28436967}. Nucleus {ECO:0000269|PubMed:9819352}. Note=Localizes to spindle poles during mitosis. Associates with microtubule minus ends (PubMed:28436967). The nuclear-cytoplasmic distribution could be regulated by the availability of calmodulin. {ECO:0000269|PubMed:28436967}.
uniprot
proteins