Pde6g
entrez
18588
canonical
uniprot
P09174
canonical
ensembl
ENSMUSG00000025386
resolver
ensp
ENSMUSP00000026452
resolver
enst
ENSMUST00000026452
resolver
genesymbol
Pde6g
resolver
genesymbol_syn
Pdeg
resolver
uniprot
Q542R6
resolver
uniprot_entry
CNRG_MOUSE
resolver
uniprot_entry
Q542R6_MOUSE
resolver
amino_acid_sequence
MNLEPPKGEIRSATRVIGGPVTPRKGPPKFKQRQTRQFKSKPPKKGVQGFGDDIPGMEGLGTDITVICPWEAFNHLELHELAQYGII
uniprot
proteins
disease_involvement
DISEASE: Note=Deficiency in GMP-PDE activity cause accumulation of cGMP in visual cells. The elevated cGMP levels are associated with degeneration of the photoreceptors and blindness. {ECO:0000303|PubMed:2835267}.
uniprot
proteins
function
FUNCTION: Inhibitory gamma subunit of the rod-specific cGMP phosphodiesterase (PDE6) complex, which hydrolyzes 3',5'-cyclic GMP in the phototransduction cascade. The PDE6 holoenzyme consists of two catalytic subunits (PDE6A and PDE6B) and two inhibitory gamma subunits. Light-activated GNAT1 relieves gamma subunit-mediated inhibition, enabling the catalytic subunits to hydrolyze cGMP and thereby mediate visual signal transduction and amplification. {ECO:0000250|UniProtKB:P04972}.
uniprot
proteins
mass_dalton
9637
uniprot
proteins
protein_family
Rod/cone cGMP-PDE gamma subunit family
uniprot
proteins
pubmed
11944991
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
2835267
uniprot
proteins
sequence_length
87
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:P04972}.
uniprot
proteins