Slc30a8
entrez
299903
canonical
uniprot
P0CE46
canonical
ensembl
ENSRNOG00000004747
resolver
ensembl
ENSRNOG00055021677
resolver
ensembl
ENSRNOG00060003155
resolver
ensembl
ENSRNOG00065014921
resolver
ensp
ENSRNOP00000006410
resolver
ensp
ENSRNOP00055030199
resolver
ensp
ENSRNOP00060003825
resolver
ensp
ENSRNOP00065019265
resolver
enst
ENSRNOT00000006410
resolver
enst
ENSRNOT00055037112
resolver
enst
ENSRNOT00060005189
resolver
enst
ENSRNOT00065024677
resolver
genesymbol
Slc30a8
resolver
genesymbol_syn
Znt8
resolver
uniprot_entry
ZNT8_RAT
resolver
amino_acid_sequence
MEFLERTYLVNDQATKMYAFTSDRERGQKPVNKDQCPGDGPERPEAGAIYHCHNSFKATGNRSSKQVHAKWRLCAASAICFFFMVAEVVGGHVAGSLAVLTDAAHLLIDLTSFLLSLFSLWLSSRPPSKRLTFGWYRAEILGALLSVLCIWVVTGVLVYLACERLLYPDYQIQAGIMITVSGCAVAANIVLTLILHQRHLGHNHKDAQANASVRAAFVHALGDVFQSTSVLISALIIYFKPDYKMADPVCTFISSVLALASTVMILKDFSILLMEGVPKGLSYNSVKELLLTVDGVISVHNLHIWSLTVNQVILSVHVATAASQDSQSVRTGIACALSSSFDLHSLTIQIESAADQDPSCLLCEDPQD
uniprot
proteins
function
FUNCTION: Proton-coupled zinc ion antiporter mediating the entry of zinc into the lumen of pancreatic beta cell secretory granules, thereby regulating insulin secretion. {ECO:0000269|PubMed:19479076}.
uniprot
proteins
mass_dalton
40128
uniprot
proteins
protein_family
Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
uniprot
proteins
protein_family
SLC30A subfamily
uniprot
proteins
pubmed
19095428
uniprot
proteins
pubmed
19243577
uniprot
proteins
pubmed
19479076
uniprot
proteins
sequence_length
368
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000269|PubMed:19095428}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q8IWU4}; Multi-pass membrane protein {ECO:0000255}. Note=Associated with insulin and glucagon secretory granules. {ECO:0000250|UniProtKB:Q8IWU4}.
uniprot
proteins
transmembrane_region
TRANSMEM 79..99; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 103..123; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 140..160; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 175..195; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 217..237; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 246..266; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins