Sh3bp1
entrez
20401
canonical
uniprot
P55194
canonical
ensembl
ENSMUSG00000022436
resolver
ensp
ENSMUSP00000001226
resolver
ensp
ENSMUSP00000052181
resolver
ensp
ENSMUSP00000105320
resolver
enst
ENSMUST00000001226
resolver
enst
ENSMUST00000061239
resolver
enst
ENSMUST00000109698
resolver
genesymbol
Sh3bp1
resolver
genesymbol_syn
3bp1
resolver
uniprot
A2A5V2
resolver
uniprot
A2A5V3
resolver
uniprot
A2A5V4
resolver
uniprot
E9QMQ2
resolver
uniprot
Q99KK8
resolver
uniprot_entry
3BP1_MOUSE
resolver
uniprot_entry
A2A5V2_MOUSE
resolver
uniprot_entry
A2A5V3_MOUSE
resolver
uniprot_sec
A2A5V4
resolver
uniprot_sec
E9QMQ2
resolver
uniprot_sec
Q99KK8
resolver
amino_acid_sequence
MMKRQLHRMRQLAHTGSSGRTPETAEFLGEDLLQVEQRLEPAKRAAHNVHKRLQACLQGQSGADMDKRVKKLPLMALSTTMAESFKELDPDSSMGKALEMTCAIQNQLARILAEFEMTLERDVLQPLSRLSEEELPAILKHKKSLQKLVSDWNTLKSRLSQAAKNSGSNQGLGGASGSHTHTTTANKVEMLKEEEEELKKKVEQCKDEYLADLYHFSTKEDSYANYFIHLLEIQADYHRKSLTSLDTALAELRDNHSQADHSPLTTAAPFSRVYGVSLRTHLQDLGRDIALPIEACVLLLLSEGMQEEGLFRLAAGASVLKRLKQTMASDPHSLEEFCSDPHAVAGALKSYLRELPEPLMTSDLYDDWMRAASLKEPGARLEALHDVCSRLPQENFNNLRYLMKFLALLAEEQDVNKMTPSNIAIVLGPNLLWPPEKEGDQAQLDAASVSSIQVVGVVEALIQNADTLFPGDINFNVSGIFPGLAPQEKVSSQQVSEELPPVTVPAPATTPAPTPAPASMAVRERTEADLPKPTSPKVSRNPTETAASAEDMTRKTKRPAPARPTMPPPQPSSTRSSPPAPSLPPGSVSPGTPQALPRRLVGTSLRAPTMPPPLPPVPPQPARRQSRRLPASPVISNMPAQVDQGVATEDRGGPEAVGGHPPPPALPPQPRPRGLISETE
uniprot
proteins
function
FUNCTION: GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form (PubMed:7621827). By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration. Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions. Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment. It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (By similarity). {ECO:0000250|UniProtKB:Q9Y3L3, ECO:0000269|PubMed:7621827}.
uniprot
proteins
mass_dalton
74172
uniprot
proteins
pubmed
10508610
uniprot
proteins
pubmed
1379745
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22891260
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
7621827
uniprot
proteins
pubmed
8438166
uniprot
proteins
sequence_length
680
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection {ECO:0000250|UniProtKB:Q9Y3L3}. Cell junction, tight junction {ECO:0000269|PubMed:22891260}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9Y3L3}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:Q9Y3L3}. Nucleus {ECO:0000250|UniProtKB:Q9Y3L3}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9Y3L3}. Note=Localizes at the leading edge of migrating cells. Accumulation at forming phagocytic cups is PI3 kinase/PI3K-dependent and is specific for sites of large particles engagement and their phosphatidylinositol 3,4,5-triphosphate membrane content. {ECO:0000250|UniProtKB:Q9Y3L3}.
uniprot
proteins