Glra3
entrez
110304
canonical
uniprot
Q91XP5
canonical
ensembl
ENSMUSG00000038257
resolver
ensp
ENSMUSP00000000275
resolver
ensp
ENSMUSP00000159349
resolver
ensp
ENSMUSP00000187183
resolver
enst
ENSMUST00000000275
resolver
enst
ENSMUST00000239388
resolver
genesymbol
Glra3
resolver
uniprot
G5E811
resolver
uniprot
Q7TSQ2
resolver
uniprot_entry
G5E811_MOUSE
resolver
uniprot_entry
GLRA3_MOUSE
resolver
uniprot_sec
Q7TSQ2
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by prostaglandin E2, probably via PKA-mediated phosphorylation at Ser-379 (PubMed:15131310). {ECO:0000269|PubMed:15131310}.
uniprot
proteins
amino_acid_sequence
MAHVRHFRTLVSGFYFWEAALLLSLVATKETNSARSRSAPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRKNKTEAFALEKFYRFSDTDDEVRESRFSFTAYGMGPCLQAKDGVVPKGPNHAVQVMPKSPDEMRKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIYKILRHEDIHQQQD
uniprot
proteins
function
FUNCTION: Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:15131310, PubMed:20978350). Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (PubMed:15131310). Contributes to increased pain perception in response to increased prostaglandin E2 levels (PubMed:15131310). Plays a role in the regulation of breathing rhythm, especially of the duration of the postinspiratory phase (PubMed:20978350). Plays a role in cellular responses to ethanol (By similarity). {ECO:0000250|UniProtKB:P24524, ECO:0000269|PubMed:15131310, ECO:0000269|PubMed:20978350}.
uniprot
proteins
mass_dalton
53709
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKA; this causes down-regulation of channel activity. Dephosphorylated in response to activation of HTR1A signaling; this increases channel activity (PubMed:20978350). {ECO:0000250|UniProtKB:P24524, ECO:0000269|PubMed:20978350}.
uniprot
proteins
protein_family
GLRA3 sub-subfamily
uniprot
proteins
protein_family
Glycine receptor (TC 1.A.9.3) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
12975813
uniprot
proteins
pubmed
15131310
uniprot
proteins
pubmed
19723286
uniprot
proteins
pubmed
20978350
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
464
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000305|PubMed:12975813, ECO:0000305|PubMed:15131310, ECO:0000305|PubMed:19723286}; Multi-pass membrane protein {ECO:0000305}. Synapse {ECO:0000269|PubMed:12975813, ECO:0000269|PubMed:15131310, ECO:0000269|PubMed:19723286}. Perikaryon {ECO:0000269|PubMed:19723286}. Cell projection, dendrite {ECO:0000250|UniProtKB:P24524}. Cell membrane {ECO:0000269|PubMed:20978350}; Multi-pass membrane protein {ECO:0000305}. Note=Partially colocalizes with GPHN that is known to mediate receptor clustering at postsynaptic membranes. {ECO:0000269|PubMed:15131310}.
uniprot
proteins
transmembrane_region
TRANSMEM 256..277; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:O75311"; TRANSMEM 283..303; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:O75311"; TRANSMEM 315..335; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:O75311"; TRANSMEM 431..451; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:O75311
uniprot
proteins