Arx
entrez
317268
canonical
uniprot
A6YP92
canonical
ensembl
ENSRNOG00000053562
resolver
ensembl
ENSRNOG00055030029
resolver
ensembl
ENSRNOG00060015194
resolver
ensembl
ENSRNOG00065010046
resolver
ensp
ENSRNOP00000071239
resolver
ensp
ENSRNOP00055042999
resolver
ensp
ENSRNOP00060020858
resolver
ensp
ENSRNOP00065012245
resolver
enst
ENSRNOT00000089828
resolver
enst
ENSRNOT00055052063
resolver
enst
ENSRNOT00060026049
resolver
enst
ENSRNOT00065016166
resolver
genesymbol
Arx
resolver
uniprot_entry
ARX_RAT
resolver
amino_acid_sequence
MSNQYQEEGCSERPECKSKSPTLLSSYCIDSILGRRSPCKMRLLGAAQSLPAPLASRTDQEKAMQGSPKGSSAPFEAELHLPPKLRRLYGPGGGRLLQGAAAAAAAAAAAAAAAATATGTAGPRGEVPPPPPPAARPGERQDSAGAVAAAAAAAWDTLKISQAPQVSISRSKSYRENGAPFVPPPPALDELGGPGGVAHPEERLSAASGPGSAPAAGGGTGTEEDEEELLEDEEDEDEEEELLEDDEEELLEDDARALLKEPRRCSVATTGTVAAAAAAAAAAAAVATEGGELSPKEELLLHPEDAEGKDGEDSVCLSAGSDSEEGLLKRKQRRYRTTFTSYQLEELERAFQKTHYPDVFTREELAMRLDLTEARVQVWFQNRRAKWRKREKAGAQTHPPGLPFPGPLSATHPLSPYLDASPFPPHHPALDSAWTAAAAAAAAAFPSLPPPPGSASLPPSGAPLGLSTFLGAAVFRHPAFISPAFGRLFSTMAPLTSASTAAALLRQPTPAVEGAVASGALADPATAAADRRASSIAALRLKAKEHAAQLTQLNILPGTSTGKEVC
uniprot
proteins
function
FUNCTION: DNA-binding transcription factor that plays a central role in the differentiation and development of type A pancreatic cells, which are located in the islets of Langerhans and secrete glucagon. Binds to specific sequence motif 5'-TAATTA-3' in regulatory elements of target genes. Also plays a key role in intestinal enteroendocrine cell differentiation by promoting differentiation of intestinal enteroendocrine cell types L, -N, -D, -I and -G. Required for normal brain development: plays a role in neuronal proliferation, interneuronal migration and differentiation in the embryonic forebrain. May also be involved in axonal guidance in the floor plate. Promotes expression of transcription of KDM5C (By similarity). Activates expression of KDM5C synergistically with histone lysine demethylase PHF8 and perhaps in competition with transcription regulator ZNF711; synergy may be related to enrichment of histone H3K4me3 in regulatory elements (By similarity). {ECO:0000250|UniProtKB:O35085, ECO:0000250|UniProtKB:Q96QS3}.
uniprot
proteins
mass_dalton
58647
uniprot
proteins
protein_family
Bicoid subfamily
uniprot
proteins
protein_family
Paired homeobox family
uniprot
proteins
sequence_length
566
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000255|PROSITE-ProRule:PRU00138}. Chromosome {ECO:0000250|UniProtKB:Q96QS3}.
uniprot
proteins