PTGR2
entrez
145482
canonical
uniprot
Q8N8N7
canonical
ensembl
ENSG00000140043
resolver
ensp
ENSP00000267568
resolver
ensp
ENSP00000450824
resolver
ensp
ENSP00000450975
resolver
ensp
ENSP00000452280
resolver
ensp
ENSP00000529294
resolver
ensp
ENSP00000529297
resolver
ensp
ENSP00000529298
resolver
ensp
ENSP00000529299
resolver
ensp
ENSP00000529301
resolver
ensp
ENSP00000788824
resolver
ensp
ENSP00000798613
resolver
enst
ENST00000553813
resolver
genesymbol
HEL-S-298
resolver
genesymbol
PTGR2
resolver
genesymbol_syn
ZADH1
resolver
hgnc
HGNC:20149
resolver
uniprot
G3V2R9
resolver
uniprot
Q3L8A4
resolver
uniprot
Q6MZH8
resolver
uniprot
V9HW32
resolver
uniprot_entry
G3V2R9_HUMAN
resolver
uniprot_entry
PTGR2_HUMAN
resolver
uniprot_entry
V9HW32_HUMAN
resolver
uniprot_sec
Q3L8A4
resolver
uniprot_sec
Q6MZH8
resolver
amino_acid_sequence
MIVQRVVLNSRPGKNGNPVAENFRMEEVYLPDNINEGQVQVRTLYLSVDPYMRCRMNEDTGTDYITPWQLSQVVDGGGIGIIEESKHTNLTKGDFVTSFYWPWQTKVILDGNSLEKVDPQLVDGHLSYFLGAIGMPGLTSLIGIQEKGHITAGSNKTMVVSGAAGACGSVAGQIGHFLGCSRVVGICGTHEKCILLTSELGFDAAINYKKDNVAEQLRESCPAGVDVYFDNVGGNISDTVISQMNENSHIILCGQISQYNKDVPYPPPLSPAIEAIQKERNITRERFLVLNYKDKFEPGILQLSQWFKEGKLKIKETVINGLENMGAAFQSMMTGGNIGKQIVCISEEISL
uniprot
proteins
ec_number
1.3.1.48
uniprot
proteins
function
FUNCTION: Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest activity towards 15-keto-PGE2 (PubMed:19000823). Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q8VDQ1, ECO:0000269|PubMed:19000823}.
uniprot
proteins
mass_dalton
38499
uniprot
proteins
mutagenesis
MUTAGEN 64; /note="Y->F: Increases affinity for 15-keto-PGE2. Reduces affinity for NADP and Vmax."; /evidence="ECO:0000269|PubMed:19000823"; MUTAGEN 259; /note="Y->F: Increases affinity for 15-keto-PGE2. Reduces affinity for NADP and Vmax."; /evidence="ECO:0000269|PubMed:19000823
uniprot
proteins
protein_family
NADP-dependent oxidoreductase L4BD family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15004468
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19000823
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
351
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins