Ralbp1
entrez
84014
canonical
uniprot
Q62796
canonical
ensembl
ENSRNOG00000013461
resolver
ensp
ENSRNOP00000073726
resolver
enst
ENSRNOT00000084884
resolver
genesymbol
Ralbp1
resolver
uniprot
A0A0G2K694
resolver
uniprot
A0A9K3Y7X7
resolver
uniprot
O55195
resolver
uniprot
Q5FVT1
resolver
uniprot_entry
A0A9K3Y7X7_RAT
resolver
uniprot_entry
Q5FVT1_RAT
resolver
uniprot_entry
RBP1_RAT
resolver
uniprot_sec
A0A0G2K694
resolver
uniprot_sec
O55195
resolver
amino_acid_sequence
MTECFLPPTSSPSEHRRAEHGSGLTRTPSSEEISPTKFPELYRTGEPSPPHDILHEPPDIVSDDEKDHGKKKGKFKKKEKRTEGYVAFQEDSSGDEAESPSKMKRSKGIHVFKKPSFSKKKEKDFKIKEKPKEEKHKEEKHKEEKHKEKKCKDFTAADVVKQWKEKKKKKKPTQEPEVPQTDAPSLRPIFGAPFADAVERTMMYDGIRLPAVFRECVDYMEKHGMKCEGIYRVSGIKSKVDELKAAYDREESPNLEEYEPNTVASLLKQYLRDLPENLLTKELMPRFEEACGRTTEVEKVQEFQRLLRELPEYNHLLLSWLIVHMDHVIAKELETKMNIQNISIVLSPTVQISNRVLYVLFTHVQELFGTVLLKQVTRPLRWSNMATMPTLPETQAGIKEEIRRQEFLLNCLHRDLQGGIKDFSKEERLWEVQRILTALKRKLREAKRQECETKIAQEIASLSKEDVSKEETNENEEVINILLAQENEILTEQEELLAMEQFLRRQIASEKEEIDRLRAEIAEIQSRQHGRSETEEYSSDSESESEDEEELQIILEDLQRQNEELEIKNNHLNQAVHEEREAIVELRVQLRLLQMLRAKSEQQLQEEEEPERRGGTGPLPCEGVLEVRAAKEQAKPSPSKDRKETPI
uniprot
proteins
ec_number
7.6.2.2
uniprot
proteins
ec_number
7.6.2.3
uniprot
proteins
function
FUNCTION: Multifunctional protein that functions as a downstream effector of RALA and RALB. As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity (PubMed:7623849, PubMed:9422736). As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis (PubMed:10393179). During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle. During mitosis, also controls mitochondrial fission as an effector of RALA. Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L (By similarity). {ECO:0000250|UniProtKB:Q15311, ECO:0000269|PubMed:10393179, ECO:0000269|PubMed:7623849, ECO:0000269|PubMed:9422736}.; FUNCTION: Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance. {ECO:0000250|UniProtKB:Q15311}.
uniprot
proteins
mass_dalton
75252
uniprot
proteins
post_translational_modification
PTM: Tyrosine-phosphorylated upon stimulation of cells with EGF. {ECO:0000250|UniProtKB:Q62172}.; PTM: May undergo proteolytic cleavage to give peptides which reassemble to form a transporter complex. {ECO:0000250|UniProtKB:Q15311}.
uniprot
proteins
pubmed
10393179
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7623849
uniprot
proteins
pubmed
9395447
uniprot
proteins
pubmed
9422736
uniprot
proteins
pubmed
9973605
uniprot
proteins
sequence_length
647
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q15311}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q15311}. Cytoplasm, cytosol {ECO:0000269|PubMed:9973605}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:9973605}. Nucleus {ECO:0000250|UniProtKB:Q15311}. Mitochondrion {ECO:0000250|UniProtKB:Q15311}. Note=Cytosolic protein that transiently associates with the mitotic spindle poles in early prophase, and dissociates from them after completion of mitosis (PubMed:9973605). Targeted to the plasma membrane through its interaction with RALB, directed by FGF signaling. Docking on the membrane is required to transduce the Ral signal (By similarity). Recruited by RALA to the mitochondrion during mitosis where it regulates mitochondrial fission. Nuclear localization is cell cycle dependent while membrane localization is seen in adherent cells. The region involved in membrane association could form transmembrane domains and expose a part of the protein extracellularly (By similarity). {ECO:0000250|UniProtKB:Q15311, ECO:0000250|UniProtKB:Q9PT60, ECO:0000269|PubMed:9973605}.
uniprot
proteins