Gpm6a
entrez
306439
canonical
uniprot
Q812E9
canonical
ensembl
ENSRNOG00000010731
resolver
ensembl
ENSRNOG00055007814
resolver
ensembl
ENSRNOG00060007153
resolver
ensembl
ENSRNOG00065014802
resolver
ensp
ENSRNOP00000075962
resolver
ensp
ENSRNOP00000075966
resolver
ensp
ENSRNOP00000099582
resolver
enst
ENSRNOT00000092968
resolver
genesymbol
Gpm6a
resolver
genesymbol_syn
m6a
resolver
uniprot
A0A1B0GWN8
resolver
uniprot_entry
A0A1B0GWN8_RAT
resolver
uniprot_entry
GPM6A_RAT
resolver
amino_acid_sequence
MEENMEEGQTQKGCFECCIKCLGGIPYASLIATILLYAGVALFCGCGHEALSGTVNILQTYFEMARTAGDTLDVFTMIDIFKYVIYGIAAAFFVYGILLMVEGFFTTGAIKDLYGDFKITTCGRCVSAWFIMLTYLFMLAWLGVTAFTSLPVYMYFNVWTICRNTTLVEGANLCLDLRQFGIVTIGEEKKICTVSENFLRMCESTELNMTFHLFIVALAGAGAAVIAMVHYLMVLSANWAYVKDACRMQKYEDIKSKEEQELHDIHSTRSKERLNAYT
uniprot
proteins
function
FUNCTION: Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells (By similarity). Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. Gpm6a-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor. {ECO:0000250, ECO:0000269|PubMed:12359212, ECO:0000269|PubMed:16286650, ECO:0000269|PubMed:17548356, ECO:0000269|PubMed:19737934, ECO:0000269|PubMed:20074218, ECO:0000269|PubMed:21426347}.
uniprot
proteins
mass_dalton
31196
uniprot
proteins
mutagenesis
MUTAGEN 10; /note="T->A: Reduces motility of Gpm6a-induced filopodia; when associated with A-256, A-267 and A-268."; /evidence="ECO:0000269|PubMed:20074218"; MUTAGEN 162; /note="C->A: Abolishess cell surface expression."; /evidence="ECO:0000269|PubMed:19737934"; MUTAGEN 174; /note="C->A: Impairs Gpm6a-induced filopodium formation."; /evidence="ECO:0000269|PubMed:19737934"; MUTAGEN 174; /note="C->A: Impairs synaptic density in primary hippocampal neurons; when associated with A-192."; /evidence="ECO:0000269|PubMed:19737934"; MUTAGEN 192; /note="C->A: Impairs Gpm6a-induced filopodium formation."; /evidence="ECO:0000269|PubMed:19737934"; MUTAGEN 192; /note="C->A: Impairs synaptic density in primary hippocampal neurons; when associated with A-174."; /evidence="ECO:0000269|PubMed:19737934"; MUTAGEN 202; /note="C->A: Abolishess cell surface expression."; /evidence="ECO:0000269|PubMed:19737934"; MUTAGEN 256; /note="S->A: Reduces motility of Gpm6a-induced filopodia; when associated with A-10, A-267 and A-268."; /evidence="ECO:0000269|PubMed:20074218"; MUTAGEN 267; /note="S->A: Reduces motility of Gpm6a-induced filopodia; when associated with A-10, A-256 and A-268."; /evidence="ECO:0000269|PubMed:20074218"; MUTAGEN 268; /note="T->A: Reduces motility of Gpm6a-induced filopodia; when associated with A-10, A-256 and A-267."; /evidence="ECO:0000269|PubMed:20074218
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:P51674}.; PTM: Palmitoylated by ZDHHC17/HIP14. {ECO:0000250|UniProtKB:P51674}.
uniprot
proteins
protein_family
Myelin proteolipid protein family
uniprot
proteins
pubmed
12359212
uniprot
proteins
pubmed
15326124
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16286650
uniprot
proteins
pubmed
17548356
uniprot
proteins
pubmed
19180239
uniprot
proteins
pubmed
19737934
uniprot
proteins
pubmed
20074218
uniprot
proteins
pubmed
21426347
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
278
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16286650, ECO:0000269|PubMed:21426347}; Multi-pass membrane protein. Cell projection, axon {ECO:0000269|PubMed:20074218}. Cell projection, growth cone {ECO:0000250|UniProtKB:P35802}. Cell projection, dendritic spine {ECO:0000269|PubMed:16286650}. Cell projection, filopodium {ECO:0000269|PubMed:16286650}. Cell projection, neuron projection {ECO:0000269|PubMed:16286650, ECO:0000269|PubMed:21426347}. Note=Localizes to cholesterol-rich lipid rafts of the plasma membrane of hippocampal neurons (PubMed:21426347). Localized to plasma membrane of cell bodies and neurites of hippocampal neurons (PubMed:16286650). Localized in membrane protrusions (filopodia and spines) of primary hippocampal neurons (PubMed:16286650). Localized to the growth cone edge membrane of elongating axons (By similarity). {ECO:0000250|UniProtKB:P35802, ECO:0000269|PubMed:16286650, ECO:0000269|PubMed:21426347}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..43; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 85..105; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 128..148; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 214..234; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins