FCRL3
entrez
115352
canonical
uniprot
Q96P31
canonical
ensembl
ENSG00000160856
resolver
ensp
ENSP00000357167
resolver
ensp
ENSP00000357169
resolver
ensp
ENSP00000540182
resolver
genesymbol
FCRL3
resolver
genesymbol_syn
FCRH3
resolver
genesymbol_syn
IFGP3
resolver
genesymbol_syn
IRTA3
resolver
genesymbol_syn
SPAP2
resolver
hgnc
HGNC:18506
resolver
uniprot
A0N0M4
resolver
uniprot
A8MTH7
resolver
uniprot
D3DVD2
resolver
uniprot
Q5VXZ8
resolver
uniprot
Q8N6S2
resolver
uniprot
Q96LA4
resolver
uniprot
Q96P27
resolver
uniprot
Q96P28
resolver
uniprot
Q96P29
resolver
uniprot
Q96P30
resolver
uniprot_entry
FCRL3_HUMAN
resolver
uniprot_sec
A0N0M4
resolver
uniprot_sec
A8MTH7
resolver
uniprot_sec
D3DVD2
resolver
uniprot_sec
Q5VXZ8
resolver
uniprot_sec
Q8N6S2
resolver
uniprot_sec
Q96LA4
resolver
uniprot_sec
Q96P27
resolver
uniprot_sec
Q96P28
resolver
uniprot_sec
Q96P29
resolver
uniprot_sec
Q96P30
resolver
amino_acid_sequence
MLLWLLLLILTPGREQSGVAPKAVLLLNPPWSTAFKGEKVALICSSISHSLAQGDTYWYHDEKLLKIKHDKIQITEPGNYQCKTRGSSLSDAVHVEFSPDWLILQALHPVFEGDNVILRCQGKDNKNTHQKVYYKDGKQLPNSYNLEKITVNSVSRDNSKYHCTAYRKFYILDIEVTSKPLNIQVQELFLHPVLRASSSTPIEGSPMTLTCETQLSPQRPDVQLQFSLFRDSQTLGLGWSRSPRLQIPAMWTEDSGSYWCEVETVTHSIKKRSLRSQIRVQRVPVSNVNLEIRPTGGQLIEGENMVLICSVAQGSGTVTFSWHKEGRVRSLGRKTQRSLLAELHVLTVKESDAGRYYCAADNVHSPILSTWIRVTVRIPVSHPVLTFRAPRAHTVVGDLLELHCESLRGSPPILYRFYHEDVTLGNSSAPSGGGASFNLSLTAEHSGNYSCDADNGLGAQHSHGVSLRVTVPVSRPVLTLRAPGAQAVVGDLLELHCESLRGSFPILYWFYHEDDTLGNISAHSGGGASFNLSLTTEHSGNYSCEADNGLGAQHSKVVTLNVTGTSRNRTGLTAAGITGLVLSILVLAAAAALLHYARARRKPGGLSATGTSSHSPSECQEPSSSRPSRIDPQEPTHSKPLAPMELEPMYSNVNPGDSNPIYSQIWSIQHTKENSANCPMMHQEHEELTVLYSELKKTHPDDSAGEASSRGRAHEEDDEENYENVPRVLLASDH
uniprot
proteins
disease_involvement
DISEASE: Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. {ECO:0000269|PubMed:15838509, ECO:0000269|PubMed:16176992, ECO:0000269|PubMed:16476711, ECO:0000269|PubMed:16859508, ECO:0000269|PubMed:17133579, ECO:0000269|PubMed:17179172, ECO:0000269|PubMed:17763442, ECO:0000269|PubMed:22392608, ECO:0000269|PubMed:26746625}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; DISEASE: Note=Genetic variation in FCRL3 may influence susceptibility to autoimmune disorders, including Graves disease or multiple sclerosis. Graves disease is an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism. Multiple sclerosis is an autoimmune/inflammatory neurodegenerative disease which mainly affects young adults and is characterized by destruction of myelin in the central nervous system. {ECO:0000269|PubMed:15838509, ECO:0000269|PubMed:16384851, ECO:0000269|PubMed:17952073, ECO:0000269|PubMed:25862376, ECO:0000269|PubMed:26629249}.
uniprot
proteins
function
FUNCTION: Promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells (PubMed:23857366). Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling (PubMed:19843936). Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T-cells (PubMed:19494275, PubMed:20190142). Acts as a human-specific epitope on the cell surface of oocytes (oolemma) and plays a role during sperm-egg adhesion and fusion (PubMed:36070373). Interacts with the IZUMO1-IZUMO1R/JUNO sperm-egg complex and replaces IZUMO1R/JUNO as IZUMO1 receptor during fertilization, thereby permitting species-specific gamete fusion (PubMed:36070373). {ECO:0000269|PubMed:19494275, ECO:0000269|PubMed:19843936, ECO:0000269|PubMed:20190142, ECO:0000269|PubMed:23857366, ECO:0000269|PubMed:36070373}.
uniprot
proteins
mass_dalton
80856
uniprot
proteins
mutagenesis
MUTAGEN 650; /note="Y->F: No effect on inhibition of cell death. No effect on interaction with INPP5D, PTPN6 and PTPN11. Loss of phosphorylation, calcium influx inhibition and interaction with INPP5D, PTPN6 and PTPN11; when associated with F-662; F-692 and F-722. Alters binding with SYK and ZAP70; when associated with F-662. Decreases calcium influx inhibition; when associated with F-662 and F-722. Decreases calcium influx inhibition; when associated with F-692 and F-722."; /evidence="ECO:0000269|PubMed:12051764, ECO:0000269|PubMed:19843936"; MUTAGEN 662; /note="Y->F: Reduces inhibition of cell death. Decreases interaction with INPP5D and PTPN6. No effect on interaction with PTPN11. Loss of phosphorylation, calcium influx inhibition and interaction with INPP5D, PTPN6 and PTPN11; when associated with F-650; F-692 and F-722. Alters binding with SYK and ZAP70; when associated with F-650. Decreases calcium influx inhibition; when associated with F-650 and F-722. Increases calcium influx inhibition; when associated with F-650 and F-722."; /evidence="ECO:0000269|PubMed:12051764, ECO:0000269|PubMed:19843936"; MUTAGEN 692; /note="Y->F: Partially reduces inhibition of cell death. Decreases interaction with INPP5D and PTPN11. No effect on interaction with PTPN6. Loss of phosphorylation, calcium influx inhibition and interaction with INPP5D, PTPN6 and PTPN11; when associated with F-650; F-662 and F-722. Alters binding with PTPN6 and PTPN11; when associated with F-772. Decreases calcium influx inhibition; when associated with F-650 and F-722. Increases calcium influx inhibition; when associated with F-650 and F-662. Decreases calcium influx inhibition; when associated with F-722."; /evidence="ECO:0000269|PubMed:12051764, ECO:0000269|PubMed:19843936"; MUTAGEN 722; /note="Y->F: No effect on inhibition of cell death. No effect on interaction with INPP5D, PTPN6 and PTPN11. Loss of phosphorylation, calcium influx inhibition and interaction with INPP5D, PTPN6 and PTPN11; when associated with F-650; F-662 and F-692. Alters binding with PTPN6 and PTPN11; when associated with F-692. Decreases calcium influx inhibition; when associated with F-650 and F-662. Decreases calcium influx inhibition; when associated with F-650 and F-692. Decreases calcium influx inhibition; when associated with F-692."; /evidence="ECO:0000269|PubMed:12051764, ECO:0000269|PubMed:19843936
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on cytoplasmic tyrosines; required for interaction with protein tyrosine phosphatases and protein tyrosine kinases. {ECO:0000269|PubMed:12051764}.
uniprot
proteins
pubmed
11493702
uniprot
proteins
pubmed
11929751
uniprot
proteins
pubmed
12051764
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15838509
uniprot
proteins
pubmed
16176992
uniprot
proteins
pubmed
16384851
uniprot
proteins
pubmed
16476711
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16849395
uniprot
proteins
pubmed
16859508
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17133579
uniprot
proteins
pubmed
17179172
uniprot
proteins
pubmed
17763442
uniprot
proteins
pubmed
17952073
uniprot
proteins
pubmed
19494275
uniprot
proteins
pubmed
19843936
uniprot
proteins
pubmed
20190142
uniprot
proteins
pubmed
22392608
uniprot
proteins
pubmed
23857366
uniprot
proteins
pubmed
25862376
uniprot
proteins
pubmed
26629249
uniprot
proteins
pubmed
26746625
uniprot
proteins
pubmed
36070373
uniprot
proteins
sequence_length
734
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16849395, ECO:0000269|PubMed:20190142, ECO:0000269|PubMed:36070373}; Single-pass type I membrane protein {ECO:0000269|PubMed:16849395}. Cell projection, microvillus membrane {ECO:0000269|PubMed:36070373}. Note=Localized along the oolemma microvilli of unfertilized oocytes. {ECO:0000269|PubMed:36070373}.
uniprot
proteins
transmembrane_region
TRANSMEM 574..594; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins