ADRA2C
entrez
152
canonical
uniprot
P18825
canonical
ensembl
ENSG00000184160
resolver
ensp
ENSP00000386069
resolver
enst
ENST00000330055
resolver
genesymbol
ADRA2C
resolver
genesymbol_syn
ADRA2L2
resolver
genesymbol_syn
ADRA2RL2
resolver
hgnc
HGNC:283
resolver
uniprot
P35369
resolver
uniprot
Q4W594
resolver
uniprot
Q9HB49
resolver
uniprot_entry
ADA2C_HUMAN
resolver
uniprot_entry
Q4W594_HUMAN
resolver
uniprot_sec
P35369
resolver
uniprot_sec
Q9HB49
resolver
amino_acid_sequence
MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGFLIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFGQVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISAVISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLRTRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGALRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRRRRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFKFFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
uniprot
proteins
function
FUNCTION: Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate the G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression (PubMed:2842764). Control a variety of physiological processes, such as regulation of blood pressure, lipolysis and insulin release (PubMed:2842764). ADRA2A and ADRA2C mediates the presynaptic feedback inhibition of neurotransmitter release from noradrenergic nerve terminals in sympathetic and central nervous systems. ADRA2A inhibits transmitter release at high stimulation frequencies, whereas ADRA2C modulates neurotransmission at lower levels of nerve activity (By similarity). The rank order of potency for physiological agonists of ADRA2C is epinephrine > norepinephrine > dopamine (PubMed:2842764). {ECO:0000250|UniProtKB:Q01337, ECO:0000269|PubMed:2842764}.
uniprot
proteins
mass_dalton
49522
uniprot
proteins
protein_family
ADRA2C sub-subfamily
uniprot
proteins
protein_family
Adrenergic receptor subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10801795
uniprot
proteins
pubmed
15319474
uniprot
proteins
pubmed
1849485
uniprot
proteins
pubmed
2842764
uniprot
proteins
pubmed
9371698
uniprot
proteins
sequence_length
462
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein {ECO:0000269|Ref.8}.
uniprot
proteins
transmembrane_region
TRANSMEM 49..74; /note="Helical; Name=1"; /evidence="ECO:0000269|Ref.8, ECO:0007744|PDB:6KUW"; TRANSMEM 88..110; /note="Helical; Name=2"; /evidence="ECO:0000269|Ref.8, ECO:0007744|PDB:6KUW"; TRANSMEM 122..147; /note="Helical; Name=3"; /evidence="ECO:0000269|Ref.8, ECO:0007744|PDB:6KUW"; TRANSMEM 168..187; /note="Helical; Name=4"; /evidence="ECO:0000269|Ref.8, ECO:0007744|PDB:6KUW"; TRANSMEM 209..231; /note="Helical; Name=5"; /evidence="ECO:0000269|Ref.8, ECO:0007744|PDB:6KUW"; TRANSMEM 384..408; /note="Helical; Name=6"; /evidence="ECO:0000269|Ref.8, ECO:0007744|PDB:6KUW"; TRANSMEM 417..440; /note="Helical; Name=7"; /evidence="ECO:0000269|Ref.8, ECO:0007744|PDB:6KUW
uniprot
proteins