MDIG
entrez
84864
canonical
uniprot
Q8IUF8
canonical
ensembl
ENSG00000170854
resolver
ensp
ENSP00000328251
resolver
ensp
ENSP00000353395
resolver
ensp
ENSP00000377748
resolver
ensp
ENSP00000424955
resolver
ensp
ENSP00000564098
resolver
ensp
ENSP00000614405
resolver
ensp
ENSP00000647200
resolver
genesymbol
MDIG
resolver
genesymbol
RIOX2
resolver
genesymbol_syn
MDIG
resolver
genesymbol_syn
MINA
resolver
genesymbol_syn
MINA53
resolver
genesymbol_syn
NO52
resolver
hgnc
HGNC:19441
resolver
uniprot
A0A6M8YDW1
resolver
uniprot
D3DN35
resolver
uniprot
Q6AHW4
resolver
uniprot
Q6SKS0
resolver
uniprot
Q8IU69
resolver
uniprot
Q8IUF6
resolver
uniprot
Q8IUF7
resolver
uniprot
Q96C17
resolver
uniprot
Q96KB0
resolver
uniprot_entry
A0A6M8YDW1_HUMAN
resolver
uniprot_entry
RIOX2_HUMAN
resolver
uniprot_sec
D3DN35
resolver
uniprot_sec
Q6AHW4
resolver
uniprot_sec
Q6SKS0
resolver
uniprot_sec
Q8IU69
resolver
uniprot_sec
Q8IUF6
resolver
uniprot_sec
Q8IUF7
resolver
uniprot_sec
Q96C17
resolver
uniprot_sec
Q96KB0
resolver
amino_acid_sequence
MPKKAKPTGSGKEEGPAPCKQMKLEAAGGPSALNFDSPSSLFESLISPIKTETFFKEFWEQKPLLIQRDDPALATYYGSLFKLTDLKSLCSRGMYYGRDVNVCRCVNGKKKVLNKDGKAHFLQLRKDFDQKRATIQFHQPQRFKDELWRIQEKLECYFGSLVGSNVYITPAGSQGLPPHYDDVEVFILQLEGEKHWRLYHPTVPLAREYSVEAEERIGRPVHEFMLKPGDLLYFPRGTIHQADTPAGLAHSTHVTISTYQNNSWGDFLLDTISGLVFDTAKEDVELRTGIPRQLLLQVESTTVATRRLSGFLRTLADRLEGTKELLSSDMKKDFIMHRLPPYSAGDGAELSTPGGKLPRLDSVVRLQFKDHIVLTVLPDQDQSDEAQEKMVYIYHSLKNSRETHMMGNEEETEFHGLRFPLSHLDALKQIWNSPAISVKDLKLTTDEEKESLVLSLWTECLIQVV
uniprot
proteins
ec_number
1.14.11.79
uniprot
proteins
function
FUNCTION: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. Also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. May play an important role in cell growth and survival. May be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles. {ECO:0000269|PubMed:12091391, ECO:0000269|PubMed:14695334, ECO:0000269|PubMed:15534111, ECO:0000269|PubMed:15819408, ECO:0000269|PubMed:15897898, ECO:0000269|PubMed:17317935, ECO:0000269|PubMed:19502796, ECO:0000269|PubMed:23103944}.
uniprot
proteins
mass_dalton
52800
uniprot
proteins
mutagenesis
MUTAGEN 179; /note="H->Y: Abolishes demethylase activity."; /evidence="ECO:0000269|PubMed:19502796
uniprot
proteins
protein_family
MINA53 subfamily
uniprot
proteins
protein_family
ROX family
uniprot
proteins
pubmed
12091391
uniprot
proteins
pubmed
14695334
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14742713
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15534111
uniprot
proteins
pubmed
15819408
uniprot
proteins
pubmed
15897898
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17317935
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19502796
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23103944
uniprot
proteins
sequence_length
465
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12091391, ECO:0000269|PubMed:15819408}. Nucleus, nucleolus {ECO:0000269|PubMed:12091391, ECO:0000269|PubMed:15819408}.
uniprot
proteins