Q8CEK7
uniprot
Q8CEK7
canonical
amino_acid_sequence
MPWVPREHSHDDVQLQEFSRNFPVGRFPYECLEADIMAKIGLEELNGLEMEVMRRQMQMTSGRLHILEDQDATWCHKEAALFTLLVSVCIANLWLWVHW
uniprot
proteins
function
FUNCTION: Involved in the regulation of endoplasmic reticulum (ER)-mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis. May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling. {ECO:0000250|UniProtKB:Q969F0}.
uniprot
proteins
mass_dalton
11726
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
99
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q969F0}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q969F0}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q969F0}; Single-pass membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000250|UniProtKB:Q969F0}. Note=Localized to specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. Also associated with the outer surface of mitochondria at sites that are not in close contact with the ER. {ECO:0000250|UniProtKB:Q969F0}.
uniprot
proteins
transmembrane_region
TRANSMEM 79..98; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins