Pcbd2
entrez
72562
canonical
uniprot
Q9CZL5
canonical
ensembl
ENSMUSG00000021496
resolver
ensp
ENSMUSP00000021958
resolver
ensp
ENSMUSP00000167624
resolver
enst
ENSMUST00000021958
resolver
genesymbol
Pcbd2
resolver
genesymbol_syn
Dcoh2
resolver
genesymbol_syn
Dcohm
resolver
uniprot_entry
PHS2_MOUSE
resolver
amino_acid_sequence
MVAAAAVAVAAVGARSAGRWLAALRSPGASRAAMSSDAQWLTAEERDQLIPGLKAAGWSELSERDAIYKEFSFKNFNQAFGFMSRVALQAEKMNHHPEWFNVYNKVQITLTSHDCGGLTKRDVKLAQFIEKAAASL
uniprot
proteins
ec_number
4.2.1.96
uniprot
proteins
function
FUNCTION: Plays a role in tetrahydrobiopterin biosynthesis which is a cofactor for amino acid hydroxylases (PubMed:15182178). May prevent both the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity). Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (PubMed:24389307). Also acts as a coactivator for HNF1B-dependent transcription (By similarity). {ECO:0000250|UniProtKB:P61459, ECO:0000250|UniProtKB:Q9H0N5, ECO:0000269|PubMed:15182178, ECO:0000269|PubMed:24389307}.
uniprot
proteins
mass_dalton
14830
uniprot
proteins
post_translational_modification
PTM: Acetylated at Lys-124 and Lys-131. Deacetylated by SIRT1, promoting its interaction with HNF1A and inducing DNA binding by HNF1A. {ECO:0000269|PubMed:24389307}.
uniprot
proteins
protein_family
Pterin-4-alpha-carbinolamine dehydratase family
uniprot
proteins
pubmed
15182178
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
24389307
uniprot
proteins
sequence_length
136
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24389307}. Nucleus {ECO:0000269|PubMed:24389307}.
uniprot
proteins