MAFK
entrez
7975
canonical
uniprot
O60675
canonical
ensembl
ENSG00000198517
resolver
ensp
ENSP00000344903
resolver
ensp
ENSP00000385437
resolver
ensp
ENSP00000386009
resolver
ensp
ENSP00000555549
resolver
ensp
ENSP00000617355
resolver
ensp
ENSP00000617356
resolver
ensp
ENSP00000617357
resolver
enst
ENST00000343242
resolver
enst
ENST00000403150
resolver
enst
ENST00000406174
resolver
enst
ENST00000885490
resolver
enst
ENST00000947296
resolver
enst
ENST00000947297
resolver
enst
ENST00000947298
resolver
genesymbol
MAFK
resolver
hgnc
HGNC:6782
resolver
uniprot
A4D214
resolver
uniprot_entry
MAFK_HUMAN
resolver
uniprot_sec
A4D214
resolver
amino_acid_sequence
MTTNPKPNKALKVKKEAGENAPVLSDDELVSMSVRELNQHLRGLTKEEVTRLKQRRRTLKNRGYAASCRIKRVTQKEELERQRVELQQEVEKLARENSSMRLELDALRSKYEALQTFARTVARGPVAPSKVATTSVITIVKSTELSSTSVPFSAAS
uniprot
proteins
function
FUNCTION: Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:9150357). However, they act as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2, NFE2L1/NRF1, NFE2L2/NRF2 and NFE2L3/NRF3, and recruiting them to specific DNA-binding sites (PubMed:8932385, PubMed:9150357). Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor (PubMed:9150357). {ECO:0000269|PubMed:8932385, ECO:0000269|PubMed:9150357}.
uniprot
proteins
mass_dalton
17523
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
protein_family
Maf subfamily
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
8932385
uniprot
proteins
pubmed
9150357
uniprot
proteins
sequence_length
156
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins