DOK2
entrez
9046
canonical
uniprot
O60496
canonical
ensembl
ENSG00000147443
resolver
ensp
ENSP00000276420
resolver
ensp
ENSP00000522598
resolver
enst
ENST00000276420
resolver
genesymbol
DOK2
resolver
hgnc
HGNC:2991
resolver
uniprot
B4DKQ6
resolver
uniprot
Q8N5A4
resolver
uniprot_entry
B4DKQ6_HUMAN
resolver
uniprot_entry
DOK2_HUMAN
resolver
uniprot_sec
Q8N5A4
resolver
amino_acid_sequence
MGDGAVKQGFLYLQQQQTFGKKWRRFGASLYGGSDCALARLELQEGPEKPRRCEAARKVIRLSDCLRVAEAGGEASSPRDTSAFFLETKERLYLLAAPAAERGDWVQAICLLAFPGQRKELSGPEGKQSRPCMEENELYSSAVTVGPHKEFAVTMRPTEASERCHLRGSYTLRAGESALELWGGPEPGTQLYDWPYRFLRRFGRDKVTFSFEAGRRCVSGEGNFEFETRQGNEIFLALEEAISAQKNAAPATPQPQPATIPASLPRPDSPYSRPHDSLPPPSPTTPVPAPRPRGQEGEYAVPFDAVARSLGKNFRGILAVPPQLLADPLYDSIEETLPPRPDHIYDEPEGVAALSLYDSPQEPRGEAWRRQATADRDPAGLQHVQPAGQDFSASGWQPGTEYDNVVLKKGPK
uniprot
proteins
function
FUNCTION: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK2 may modulate the cellular proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in modulating Bcr-Abl signaling. Attenuates EGF-stimulated MAP kinase activation (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
45379
uniprot
proteins
post_translational_modification
PTM: On immunoreceptor stimulation, phosphorylated on C-terminal tyrosine residues. Phosphorylation on Tyr-345 is required for binding to the SH2 domain of NCK. Phosphorylation on both Tyr-271 and Tyr-299 is required for interaction with RASGAP. Phosphorylated on tyrosine residues by TEK/TIE2 (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
DOK family
uniprot
proteins
protein_family
Type A subfamily
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28841444
uniprot
proteins
pubmed
9478921
uniprot
proteins
sequence_length
412
uniprot
proteins