Spred3
entrez
101809
canonical
uniprot
Q6P6N5
canonical
ensembl
ENSMUSG00000037239
resolver
ensp
ENSMUSP00000046216
resolver
enst
ENSMUST00000048923
resolver
genesymbol
Spred3
resolver
uniprot
A0A0R4J0K0
resolver
uniprot
Q7TNJ8
resolver
uniprot_entry
A0A0R4J0K0_MOUSE
resolver
uniprot_entry
SPRE3_MOUSE
resolver
uniprot_sec
Q7TNJ8
resolver
amino_acid_sequence
MVRVRAVVMARDDSSGGWLPVGGGGLSQVSVCRVRGARPEGGARQGHYVIHGERLRDQKTTLECTLRPGLVYNKVNPIFHHWSLGDCKFGLTFQSPAEADEFQKSLLAALAALSRGSLTPSSSSSSSSPSQDTAETPCPLTSHVDSDSSSSHSRQETPPTAPIATVESAAAFPLATRPQRRRSSAQSYPPLLPFTGIPEPSESLAGAGSQGWGSRGYEDYRRSGPPPPPLALSTCVVRFAKTGALRGAALGPPVSLPAPLTEAAPPAPPARPPPGPGPTPAPAKASPEAEEAARCVHCRALFRRRADGRGGRCAEAPDPGRLLVRRLSCLWCAESLLYHCLSDAEGDFSDPCACEPGHPRPAARWAALAALSLAVPCLCCYAPLRACHWVAARCGCAGCGGRHEEAAR
uniprot
proteins
function
FUNCTION: Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (PubMed:12646235). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (PubMed:29501879). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (PubMed:25576668). {ECO:0000269|PubMed:12646235, ECO:0000269|PubMed:25576668, ECO:0000269|PubMed:29501879}.
uniprot
proteins
mass_dalton
42794
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine. {ECO:0000250|UniProtKB:Q2MJR0}.; PTM: Palmitoylated by ZDHHC17/HIP14. {ECO:0000269|PubMed:24705354}.; PTM: Ubiquitinated. {ECO:0000250|UniProtKB:Q2MJR0}.
uniprot
proteins
pubmed
12646235
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24705354
uniprot
proteins
pubmed
25576668
uniprot
proteins
pubmed
29501879
uniprot
proteins
sequence_length
408
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12646235, ECO:0000269|PubMed:24705354}; Peripheral membrane protein {ECO:0000269|PubMed:12646235}.
uniprot
proteins