Acss2
entrez
60525
canonical
uniprot
Q9QXG4
canonical
ensembl
ENSMUSG00000027605
resolver
ensp
ENSMUSP00000029135
resolver
enst
ENSMUST00000029135
resolver
genesymbol
Acss2
resolver
genesymbol_syn
Acas2
resolver
genesymbol_syn
Acecs1
resolver
uniprot
Q8BK97
resolver
uniprot_entry
ACSA_MOUSE
resolver
uniprot_sec
Q8BK97
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by acetylation at Lys-661 and activated by deacetylation mediated by the deacetylases SIRT1 and SIRT3. {ECO:0000269|PubMed:16790548}.
uniprot
proteins
amino_acid_sequence
MGLPEERRKSGSGSRAREETGAEGRVRGWSPPPEVRRSAHVPSLQRYRELHRRSVEEPREFWGNIAKEFYWKTACPGPFLQYNFDVTKGKIFTEWMKGATTNICYNVLDRNVHEKKLGDKVAFYWEGNEPGETTKITYRELLVQVCQFSNVLRKQGIQKGDRVAIYMPMILELVVAMLACARLGALHSIVFAGFSAESLCERILDSSCCLLITTDAFYRGEKLVNLKELADESLEKCREKGFPVRCCIVVKHLGRAELGMNDSPSQSPPVKRPCPDVQICWNEGVDLWWHELMQQAGDECEPEWCDAEDPLFILYTSGSTGKPKGVVHTIGGYMLYVATTFKYVFDFHPEDVFWCTADIGWITGHSYVTYGPLANGATSVLFEGIPTYPDEGRLWSIVDKYKVTKFYTAPTAIRMLMKFGDDPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGSQRCPIVDTFWQTETGGHMLTPLPGATPMKPGSASFPFFGVAPAILNESGEELEGEAEGYLVFKQPWPGIMRTVYGNHTRFETTYFKKFPGYYVTGDGCRRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVVGHPHPVKGECLYCFVTLCDGHTFSPTLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSGKIMRRVLRKIAQNDHDLGDTSTVADPSVINHLFSHRCLTTQ
uniprot
proteins
ec_number
6.2.1.-
uniprot
proteins
ec_number
6.2.1.1
uniprot
proteins
ec_number
6.2.1.17
uniprot
proteins
function
FUNCTION: Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (PubMed:11150295, PubMed:16790548, PubMed:28562591). Acetate is the preferred substrate but can also utilize propionate with a much lower affinity (PubMed:11150295). Catalyzes the conversion of lactate into lactoyl-CoA (By similarity). Does not catalyze the conversion of butyrate or crotonate to their corresponding acyl-CoAs (By similarity). Nuclear ACSS2 promotes glucose deprivation-induced lysosomal biogenesis and autophagy, tumor cell survival and brain tumorigenesis (By similarity). Glucose deprivation results in AMPK-mediated phosphorylation of ACSS2 leading to its translocation to the nucleus where it binds to TFEB and locally produces acetyl-CoA for histone acetylation in the promoter regions of TFEB target genes thereby activating their transcription (By similarity). The regulation of genes associated with autophagy and lysosomal activity through ACSS2 is important for brain tumorigenesis and tumor survival (By similarity). Acts as a chromatin-bound transcriptional coactivator that up-regulates histone acetylation and expression of neuronal genes (PubMed:28562591). Can be recruited to the loci of memory-related neuronal genes to maintain a local acetyl-CoA pool, providing the substrate for histone acetylation and promoting the expression of specific genes, which is essential for maintaining long-term spatial memory (PubMed:28562591). {ECO:0000250|UniProtKB:Q9NR19, ECO:0000269|PubMed:11150295, ECO:0000269|PubMed:16790548, ECO:0000269|PubMed:28562591}.
uniprot
proteins
mass_dalton
78862
uniprot
proteins
post_translational_modification
PTM: Reversibly acetylated at Lys-661 (PubMed:16790548). The acetyl-CoA synthase activity is inhibited by acetylation and activated by deacetylation mediated by the deacetylases SIRT1 and SIRT3. {ECO:0000269|PubMed:16790548}.
uniprot
proteins
protein_family
ATP-dependent AMP-binding enzyme family
uniprot
proteins
pubmed
11150295
uniprot
proteins
pubmed
12049778
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16790548
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28552616
uniprot
proteins
pubmed
28562591
uniprot
proteins
sequence_length
701
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:11150295, ECO:0000269|PubMed:28552616}. Cytoplasm {ECO:0000269|PubMed:28562591}. Nucleus {ECO:0000269|PubMed:28552616, ECO:0000269|PubMed:28562591}. Note=Glucose deprivation results in its AMPK-dependent phosphorylation and subsequent nuclear translocation. Phosphorylation at Ser-659, leads to exposure of its nuclear localization signal which is required for its interaction with KPNA1 and subsequent translocation to the nucleus (By similarity). Found in the cytoplasm in undifferentiated neurons and upon differentiation, translocates to nucleus (PubMed:28562591). {ECO:0000250|UniProtKB:Q9NR19, ECO:0000269|PubMed:28562591}.
uniprot
proteins