Svil
entrez
225115
canonical
uniprot
Q8K4L3
canonical
ensembl
ENSMUSG00000024236
resolver
ensp
ENSMUSP00000119803
resolver
ensp
ENSMUSP00000225554
resolver
ensp
ENSMUSP00000225555
resolver
ensp
ENSMUSP00000225557
resolver
ensp
ENSMUSP00000225558
resolver
ensp
ENSMUSP00000225559
resolver
ensp
ENSMUSP00000225560
resolver
ensp
ENSMUSP00000225561
resolver
ensp
ENSMUSP00000225562
resolver
ensp
ENSMUSP00000225563
resolver
ensp
ENSMUSP00000225564
resolver
ensp
ENSMUSP00000225565
resolver
ensp
ENSMUSP00000225566
resolver
ensp
ENSMUSP00000225567
resolver
ensp
ENSMUSP00000225569
resolver
ensp
ENSMUSP00000225570
resolver
ensp
ENSMUSP00000225572
resolver
genesymbol
Svil
resolver
uniprot
E9Q983
resolver
uniprot
Q3TTX5
resolver
uniprot_entry
Q3TTX5_MOUSE
resolver
uniprot_entry
SVIL_MOUSE
resolver
uniprot_sec
E9Q983
resolver
amino_acid_sequence
MKRKERIARRLEGIENDSQPILLQSCTGLVTHRLLEEDTPRYMRATDPASPHIGRSKEEEDTPGSSLEKQTPSKYCIETSGIHSSGSMDTHSLESKAERIARYKAERRRQLAEKYGLTLDPEADSEYLSRYAKSRKDPDVTERRGKSDKQEEQSKDANSRHSRTESGPRTSLVASQDCTPLGSNMSDQEQLLNVENQRRVQDPPLGEDGSSAFFSERSISFPEVPRSPKQIPSSPLQQPASPNHPGDSPLPTEARASTGKPTHEWFLQRDSEGDTPSLINWPSRVKVREKLVKEESARSSPELTSESLTQRRQQPAPAHFLPIQSESSTFDRVTSKAVSSLQPSQSGVLPTDPVHAIKLVTMDTPESTSEFSWVGSATPKVIKSTTLKILEGGSRDAPVLHICESKAEDWLSPEPLERSPKSLLTSEDDRLVRGHKDPSGNKDLDKAIICSIDVESERERQVQHLPTQRTGRSEMLLYVQSGPVSQDATLTSHTKEASPKKRKVLARSLSDYTGPPQLQVPRHKDEAPSQELELQSSRAEGPGAEASVLDTRVSVAQLRNIFMESTRASKKPELQSRVERSAEGIGLPMERERGSRKPRRYLSPGESRKTSERFRTQPITSAERKESDRYPSGSEIPVVEDEEKVDERAKLSVAAKRLLFREMEKSFDEHTVPKRHSRNAAVEQRLRRLQDRSHTQPITTEEVVIAATEPIPASCSGVTHPVTARLPSPTVARSSVQPARLQASAHQKALARDQANEGRESAEPGEPDSSTLSLAEKLALFNKLSQPVSKAISTRNRIDVRQRRMNARYQTQPVTLGEVEQVQSGKLISFSPTVNTSVSIMASAVAPTYAGDLRKLSVDNNTSATDYKSPPAENSDSPVRSILKPQAWRPLVEHSGSKGMPGESGKTESKNALTVAAEDSGVQTRGAFEEEEEPSYPILGRVREGDGQKEPKHVVLRRGSLELGNPSAAHLGDELKEVSTAKSSLQENLDLKDKQASEENTDVETVMRKFSLKEFGETTSEQTEVAARKASVQMATPGAWKQQESSEQLAEKLFKNPCAMFASGEVKVPVGDSFLDSPSKTMSIKERLALLKKSGEEDWKNRLIRKQEYGKATGGLHTQEVEQSLKKKRVTESRESQMTIEERKHLITVREEAWKTKGRGAANDSTQFTVAGRMVKKGLASPTSITPISSPLCSKSRGTTPVSKPLEDIEARPDMQLESDLKLDRLETFLRRLNNKVAGIQETVLTVTGKSVKEVMKLDDDETFAKFYRSVDHSIPRSPVELEEDFDVIFDPYAPKLTSSVAEHKRQVRPKRRVQASKNPLKLLAARDDLLQEYTEQRLNVAFMESKRMKVEKMSSNSNFSEVTLAGLASRENFSNINLRSVNLMEQNSNNSAMPYKKLMLLQIKGRRHVQTRLVEPRASSLNSGDCFLLLSPQYCFLWVGEFSNVIEKAKASELATLIQTKRELGCRATYIQTIEEGINTHTHAAKDFWKLLGGQTSYQSAGDPKEDELYETAIIETNCVYRLTDDKLVPDDDYWGKIPKCSLLQSKEVLVFDFGSEVYVWHGKEVTLAQRKIAFQLAKHLWNGTFDYENCDINPLDPGECNPLIPRKGQGRPDWAIFGRVTEHNETILFKEKFLDWTELKRPTEKNSGEVVQQKDDPRADVKPYDVTRMVATPQITAGTILDGVNVGRGYGLVEGDDRRQFEIATVSVDVWHILEFDYSRLPRQSIGQFHEGDAYVVKWKYMASTAVGSRQKGEHLVRVAGKEKCVYFFWQGRHSTVSEKGTSALMTVELDEERGAQVQVLQGKEPPCFLQCFQGGMVVHSGRREEEEENVQSEWRLYCVRGEVPMEGNLLEVACHCSSLRSRTSMVVLNINKALIYLWHGCKAQGHTKEVGRTAANKIKEECPLEAGLHSSSNVTIHECDEGSEPLGFWDALGRRDRKAYDCMLQDPGSFNFAPRLFILSSSSGDFSATEFVYPAQAPSAVSSMPFLQEDLYSAPQPALFLVDNHHEVYLWQGWWPTENKITGSARIRWASDRKSAMETVLQYCRGKNLKRPPPKSYLIHAGLEPLTFTNMFPSWEHREDIAEITEMDTEVSNQITLVEDVLAKLCKTIYPLADLLARPLPEGVDPLKLEIYLTDEDFEFALDMSRDEFNALPTWKQVNLKKSKGLF
uniprot
proteins
function
FUNCTION: [Isoform 1]: Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function. In addition to its cytoskeletal activities, acts as a cofactor or scaffold for KDM1A, facilitating H3K9me2 demethylation and promoting gene activation, especially in neuronal contexts (By similarity). {ECO:0000250|UniProtKB:O95425}.; FUNCTION: [Isoform 2]: May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6. Plays a role in cytokinesis through KIF14 interaction (By similarity). {ECO:0000250|UniProtKB:O46385}.
uniprot
proteins
mass_dalton
243162
uniprot
proteins
protein_family
Villin/gelsolin family
uniprot
proteins
pubmed
12711699
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
31112734
uniprot
proteins
pubmed
34272044
uniprot
proteins
sequence_length
2170
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O95425}; Peripheral membrane protein {ECO:0000250|UniProtKB:O95425}; Cytoplasmic side {ECO:0000250|UniProtKB:O95425}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O95425}. Cell projection, invadopodium {ECO:0000250|UniProtKB:O95425}. Cell projection, podosome {ECO:0000250|UniProtKB:O95425}. Midbody {ECO:0000250|UniProtKB:O46385}. Cleavage furrow {ECO:0000250|UniProtKB:O46385}. Note=Tightly associated with both actin filaments and plasma membranes. {ECO:0000250|UniProtKB:O95425}.
uniprot
proteins