Pla2g15
entrez
361401
canonical
uniprot
Q675A5
canonical
ensembl
ENSRNOG00000019859
resolver
ensembl
ENSRNOG00055018269
resolver
ensembl
ENSRNOG00060012615
resolver
ensembl
ENSRNOG00065012038
resolver
ensp
ENSRNOP00000026996
resolver
ensp
ENSRNOP00055024953
resolver
ensp
ENSRNOP00060016919
resolver
ensp
ENSRNOP00065015009
resolver
enst
ENSRNOT00000026996
resolver
enst
ENSRNOT00055030969
resolver
enst
ENSRNOT00060021420
resolver
enst
ENSRNOT00065019576
resolver
genesymbol
Pla2g15
resolver
genesymbol_syn
Lypla3
resolver
uniprot_entry
PAG15_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Transacylase activity is inhibited by MJ33. {ECO:0000269|PubMed:15294901}.
uniprot
proteins
amino_acid_sequence
MDRHLCICREIQLRSGLLFPFLLLMMLADLALPAQRHPPVVLVPGDLGNQLEAKLDKPKVVHYLCSKRTDSYFTLWLNLELLLPVIIDCWIDNIRLVYNRTSRTTQFPDGVDVRVPGFGETFSLEFLDPSKRNVGSYFYTMVESLVGWGYTRGEDVRGAPYDWRRAPNENGPYFLALQEMIEEMYQMYGGPVVLVAHSMGNMYMLYFLQRQPQAWKDKYIQAFVSLGAPWGGVAKTLRVLASGDNNRIPVIGPLKIREQQRSAVSTSWLLPYNHTWSHEKVFVYTPTANYTLRDYHRFFQDIGFEDGWFMRQDTQGLVEALVPPGVELHCLYGTGVPTPNSFYYENFPDRDPKICFGDGDGTVNLESVLQCQAWQSRQEHKVSLQELPGSEHIEMLANATTLAYLKRVLLEEP
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
ec_number
3.1.1.32
uniprot
proteins
ec_number
3.1.1.4
uniprot
proteins
ec_number
3.1.1.5
uniprot
proteins
function
FUNCTION: Has dual calcium-independent phospholipase and O-acyltransferase activities with a potential role in glycerophospholipid homeostasis and remodeling of acyl groups of lipophilic alcohols present in acidic cellular compartments (PubMed:15294901). Catalyzes hydrolysis of the ester bond of the fatty acyl group attached at sn-1 or sn-2 position of phospholipids (phospholipase A1 or A2 activity) and transfer it to the hydroxyl group at the first carbon of lipophilic alcohols (O-acyltransferase activity) (PubMed:15294901). Among preferred fatty acyl donors are phosphatidylcholines, phosphatidylethanolamines, phosphatidylglycerols and phosphatidylserines. Favors sn-2 over sn-1 deacylation of unsaturated fatty acyl groups of phosphatidylcholines, phosphatidylethanolamines, and phosphatidylglycerols (By similarity). Among preferred fatty acyl acceptors are natural lipophilic alcohols including short-chain ceramide N-acetyl-sphingosine (C2 ceramide), alkylacylglycerols, monoacylglycerols, and acylethanolamides such as anandamide and oleoylethanolamide. Selectively hydrolyzes the sn-1 fatty acyl group of truncated oxidized phospholipids and may play a role in detoxification of reactive oxidized phospholipids during oxidative stress (By similarity). Required for normal phospholipid degradation in alveolar macrophages with potential implications in the clearance of pulmonary surfactant, which is mainly composed of dipalmitoylphosphatidylcholine (1,2-dihexadecanoyl-sn-glycero-3-phosphocholine) (PubMed:15294901). Involved in the first step of bis(monoacylglycero)phosphate (BMP) de novo synthesis from phosphatidylglycerol (1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol), PG) (By similarity). BMP is an important player in cargo sorting and degradation, regulation of cellular cholesterol levels and intercellular communication. At neutral pH, hydrolyzes the sn-1 fatty acyl group of the lysophosphatidylcholines (By similarity). {ECO:0000250|UniProtKB:Q8NCC3, ECO:0000250|UniProtKB:Q8VEB4, ECO:0000269|PubMed:15294901}.
uniprot
proteins
mass_dalton
47391
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. N-glycosylation is important for maturation of the enzyme and normal subcellular location. {ECO:0000250|UniProtKB:Q8NCC3}.
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
protein_family
Lipase family
uniprot
proteins
pubmed
15294901
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
413
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000250|UniProtKB:Q6XPZ3}. Secreted {ECO:0000250|UniProtKB:Q8NCC3}. Membrane {ECO:0000250|UniProtKB:Q8NCC3}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8NCC3}.
uniprot
proteins