TDO2
entrez
6999
canonical
uniprot
P48775
canonical
ensembl
ENSG00000151790
resolver
ensembl
ENSG00000262635
resolver
ensp
ENSP00000444788
resolver
ensp
ENSP00000460086
resolver
enst
ENST00000536354
resolver
enst
ENST00000573403
resolver
genesymbol
TDO2
resolver
genesymbol_syn
TDO
resolver
hgnc
HGNC:11708
resolver
uniprot
A8K053
resolver
uniprot_entry
T23O_HUMAN
resolver
uniprot_sec
A8K053
resolver
amino_acid_sequence
MSGCPFLGNNFGYTFKKLPVEGSEEDKSQTGVNRASKGGLIYGNYLHLEKVLNAQELQSETKGNKIHDEHLFIITHQAYELWFKQILWELDSVREIFQNGHVRDERNMLKVVSRMHRVSVILKLLVQQFSILETMTALDFNDFREYLSPASGFQSLQFRLLENKIGVLQNMRVPYNRRHYRDNFKGEENELLLKSEQEKTLLELVEAWLERTPGLEPHGFNFWGKLEKNITRGLEEEFIRIQAKEESEEKEEQVAEFQKQKEVLLSLFDEKRHEHLLSKGERRLSYRALQGALMIYFYREEPRFQVPFQLLTSLMDIDSLMTKWRYNHVCMVHRMLGSKAGTGGSSGYHYLRSTVSDRYKVFVDLFNLSTYLIPRHWIPKMNPTIHKFLYTAEYCDSSYFSSDESD
uniprot
proteins
disease_involvement
DISEASE: Hypertryptophanemia (HYPTRP) [MIM:600627]: An autosomal recessive condition characterized by persistent hypertryptophanemia and hyperserotoninemia. {ECO:0000269|PubMed:28285122}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
1.13.11.11
uniprot
proteins
function
FUNCTION: Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. {ECO:0000255|HAMAP-Rule:MF_03020, ECO:0000269|PubMed:25066423, ECO:0000269|PubMed:27762317, ECO:0000269|PubMed:28285122}.
uniprot
proteins
mass_dalton
47872
uniprot
proteins
mutagenesis
MUTAGEN 42; /note="Y->A: Reduces enzyme activity by 99%."; /evidence="ECO:0000269|PubMed:25066423"; MUTAGEN 45; /note="Y->A: Reduces enzyme activity by 99%."; /evidence="ECO:0000269|PubMed:25066423"; MUTAGEN 72; /note="F->A: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:25066423"; MUTAGEN 76; /note="H->A: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:25066423"; MUTAGEN 140; /note="F->A: Reduces enzyme activity by 99%."; /evidence="ECO:0000269|PubMed:25066423"; MUTAGEN 144; /note="R->A: Reduces enzyme activity by 99%."; /evidence="ECO:0000269|PubMed:25066423"; MUTAGEN 151; /note="S->A: Reduces enzyme activity by 90%."; /evidence="ECO:0000269|PubMed:25066423"; MUTAGEN 175; /note="Y->G: Reduces enzyme activity."; /evidence="ECO:0000269|PubMed:27762317"; MUTAGEN 328; /note="H->A: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:25066423
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 1/2. {ECO:0000255|HAMAP-Rule:MF_03020, ECO:0000269|PubMed:25066423, ECO:0000269|PubMed:27762317}.
uniprot
proteins
protein_family
3-dioxygenase family
uniprot
proteins
protein_family
Tryptophan 2
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
25066423
uniprot
proteins
pubmed
27762317
uniprot
proteins
pubmed
28285122
uniprot
proteins
pubmed
8666386
uniprot
proteins
sequence_length
406
uniprot
proteins