Cops7b
entrez
26895
canonical
uniprot
Q8BV13
canonical
ensembl
ENSMUSG00000026240
resolver
ensp
ENSMUSP00000027446
resolver
ensp
ENSMUSP00000113587
resolver
ensp
ENSMUSP00000187607
resolver
enst
ENSMUST00000027446
resolver
enst
ENSMUST00000121534
resolver
genesymbol
Cops7b
resolver
genesymbol_syn
Csn7b
resolver
uniprot
O88547
resolver
uniprot
Q3TGG7
resolver
uniprot
Q921G4
resolver
uniprot_entry
CSN7B_MOUSE
resolver
uniprot_sec
O88547
resolver
uniprot_sec
Q3TGG7
resolver
uniprot_sec
Q921G4
resolver
amino_acid_sequence
MAGEQKPSSNLLEQFILLAKGTSGSALTTLISQVLEAPGVYVFGELLELANVQELAEGANAAYLQLLNLFAYGTYPDYIANKESLPELSVAQQNKLKHLTIVSLASRMKCIPYSVLLKDLEMRNLRELEDLIIEAVYTDIIQGKLDQRNQLLEVDFCIGRDIRKKDINNIVKTLHEWCDGCEAVLLGIEQQVLRANQYKENHHRTQQQVEAEVSNIKKTLKATASSSAQEMEQQLAERECPPHTEQRQPTKKMSKVKGLVSSRH
uniprot
proteins
function
FUNCTION: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
29689
uniprot
proteins
protein_family
CSN7 subfamily
uniprot
proteins
protein_family
CSN7/EIF3M family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9707402
uniprot
proteins
sequence_length
264
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
uniprot
proteins