Q9Z331
uniprot
Q9Z331
canonical
amino_acid_sequence
MSTKTTIKSQTSHRGYSASSARVPGLNRSGFSSVSVCRSRGSGGSSAMCGGAGFGSRSLYGVGSSKRISIGGGSCGIGGGYGSRFGGAYGSRFGGSFGIGGGAGSGFGFGGGVGFGGGYGGAGFPVCPPGGIQEVTINQNLLTPLNVQIDPTIQRVRTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWALLQEQGTKTVRQNLEPMFEQYISNLRRQLDSIIGERGRLDSELRNMQDTVEDYKSKYEDEINKRTKAENEFVTVKKDVDAAYMTKVELQAKADSLADEINFLRVIYEAELSQMQTHISDTSVVLSMDNNRSLDLDSIIAEVKAQYEDIAQRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEIAEINRMIQRLRSEIDHVKKQCANLQAAIADAEQRGEMALKDARGKLEGLEDALQKAKQEMARLLKEYQELMNVKLALDVEIATYRKLLEGEECRLNGEGVGPVNISVVQSTVSSGYGSAGGASSSLGLGGSSSYSYGSSHGLGGGFSAGSGRAIGGGLSSSGGLSSSTIKYTTSASSSRKSYRH
uniprot
proteins
function
FUNCTION: Structural component of intermediate filaments in epithelial keratinocytes. Forms heteropolymers with the type I keratins KRT16 and KRT17, assembling keratin intermediate filament networks that contribute to the structural integrity and stress resilience of stratified epithelia and appendages (By similarity). Induced during epidermal stress and wound repair, where it regulates keratinocyte migration and epithelial regeneration (PubMed:30389720). Negatively regulates collective keratinocyte migration by stabilizing non-muscle myosin MYH9 and desmoplakin, thereby altering cell-cell and cell-matrix adhesion and reducing the speed and directionality of epithelial sheet movement during wound repair (PubMed:30389720). Required for normal plantar and nail unit integrity (By similarity). {ECO:0000250|UniProtKB:P04259, ECO:0000269|PubMed:30389720}.
uniprot
proteins
mass_dalton
60322
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
30389720
uniprot
proteins
pubmed
8636216
uniprot
proteins
pubmed
9790766
uniprot
proteins
sequence_length
562
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:30389720}.
uniprot
proteins