Hira
entrez
15260
canonical
uniprot
Q61666
canonical
ensembl
ENSMUSG00000022702
resolver
ensp
ENSMUSP00000004222
resolver
genesymbol
Hira
resolver
genesymbol_syn
Tuple1
resolver
uniprot
O08845
resolver
uniprot
Q3TFY0
resolver
uniprot
Q3UX35
resolver
uniprot
Q62365
resolver
uniprot
Q7TMW4
resolver
uniprot_entry
HIRA_MOUSE
resolver
uniprot_sec
O08845
resolver
uniprot_sec
Q3TFY0
resolver
uniprot_sec
Q3UX35
resolver
uniprot_sec
Q62365
resolver
uniprot_sec
Q7TMW4
resolver
amino_acid_sequence
MKLLKPTWVNHNGKPIFSVDIHPDGTKFATGGQGQDSGKVVIWNMSPVLQEDDEKDENIPKMLCQMDNHLACVNCVRWSNSGMYLASGGDDKLIMVWKRATYIGPSTVFGSSGKLANVEQWRCVSILRSHSGDVMDVAWSPHDAWLASCSVDNTVVIWNAVKFPEILATLRGHSGLVKGLTWDPVGKYIASQADDRSLKVWRTLDWQLETSITKPFDECGGTTHVLRLSWSPDGHYLVSAHAMNNSGPTAQIIEREGWKTNMDFVGHRKAVTVVKFNPKIFKKKQKNGSSTKPSCPYCCCAVGSKDRSLSVWLTCLKRPLVVIHELFDKSIMDISWTLNGLGILVCSMDGSVAFLDFSQDELGDPLSEEEKSRIHQSTYGKSLAIMTEAQLSTAVIENPEMLKYQRRQQQQQLDQKNATTRETSSASSVTGVVNGESLEDIRKNLLKKQVETRTADGRRRITPLCIAQLDTGDFSTAFFNSIPLSSSLAGTMLSSPSGQQLLPLDSSTPSFGASKPCTEPVAATSARPTGESVSKDSMNATSTPAASSPSVLTTPSKIEPMKAFDSRFTERSKATPGAPSLTSVIPTAVERLKEQNLVKELRSRELESSSDSDEKVHLAKPSSLSKRKLELEVETVEKKKKGRPRKDSRLLPMSLSVQSPAALSTEKEAMCLSAPALALKLPIPGPQRAFTLQVSSDPSMYIEVENEVTTVGGIRLSRLKCNREGKEWETVLSSRVLTAAGSCDVVCVACEKRMLSVFSTCGRRLLPPILLPSPISTLHCTGPYVMALTAAATLSVWDVHRQVVVVKEESLHSILSGSDMTVSQILLTQHGIPVMNLSDGKAYCFNPSLSTWNLVSDKQDSLAQCADFRNSLPSQDAMLCSGPLAIIQGRTSNSGRQAARLFSVPHVVQQETTLAYLENQVAAALTLQSSHEYRHWLLLYARYLVNEGFEYRLREICKDLLGPVHCSTGSQWESTVVGLRKRELLKELLPVIGQNLRFQRLFTECQEQLDILRDK
uniprot
proteins
function
FUNCTION: Required for the periodic repression of histone gene transcription during the cell cycle (By similarity). Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000250, ECO:0000269|PubMed:16399082}.
uniprot
proteins
mass_dalton
111767
uniprot
proteins
post_translational_modification
PTM: Sumoylated. {ECO:0000250}.; PTM: Phosphorylated by CDK2/CCNA1 and CDK2/CCNE1 on Thr-554 in vitro (By similarity). Also phosphorylated on Thr-554 in vivo. {ECO:0000250, ECO:0000269|PubMed:11238922}.
uniprot
proteins
protein_family
WD repeat HIR1 family
uniprot
proteins
pubmed
11238922
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15922569
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16399082
uniprot
proteins
pubmed
8111380
uniprot
proteins
pubmed
8611624
uniprot
proteins
pubmed
9063745
uniprot
proteins
pubmed
9731536
uniprot
proteins
sequence_length
1015
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus, PML body {ECO:0000250}. Note=Primarily, though not exclusively, localized to the nucleus (By similarity). Localizes to PML bodies immediately prior to onset of senescence (By similarity). Localizes specifically to the male nucleus in fertilized eggs. This localization persists from the initiation of sperm nucleus decondensation to pronucleus formation. {ECO:0000250, ECO:0000269|PubMed:15922569, ECO:0000269|PubMed:9731536}.
uniprot
proteins