ANAPC13
entrez
25847
canonical
uniprot
Q9BS18
canonical
ensembl
ENSG00000129055
resolver
ensp
ENSP00000346987
resolver
ensp
ENSP00000421760
resolver
ensp
ENSP00000421842
resolver
ensp
ENSP00000427327
resolver
ensp
ENSP00000561916
resolver
ensp
ENSP00000561917
resolver
ensp
ENSP00000561918
resolver
ensp
ENSP00000561919
resolver
ensp
ENSP00000561920
resolver
ensp
ENSP00000561921
resolver
ensp
ENSP00000561922
resolver
ensp
ENSP00000561923
resolver
ensp
ENSP00000561924
resolver
ensp
ENSP00000594745
resolver
ensp
ENSP00000594746
resolver
ensp
ENSP00000594747
resolver
ensp
ENSP00000631535
resolver
ensp
ENSP00000631536
resolver
enst
ENST00000354910
resolver
enst
ENST00000510994
resolver
enst
ENST00000511751
resolver
enst
ENST00000514612
resolver
enst
ENST00000891857
resolver
enst
ENST00000891858
resolver
enst
ENST00000891859
resolver
enst
ENST00000891860
resolver
enst
ENST00000891861
resolver
enst
ENST00000891862
resolver
enst
ENST00000891863
resolver
enst
ENST00000891864
resolver
enst
ENST00000891865
resolver
enst
ENST00000924686
resolver
enst
ENST00000924687
resolver
enst
ENST00000924688
resolver
enst
ENST00000961476
resolver
enst
ENST00000961477
resolver
genesymbol
ANAPC13
resolver
hgnc
HGNC:24540
resolver
uniprot
A6NJK6
resolver
uniprot
A8K3Z6
resolver
uniprot
D3DND5
resolver
uniprot
Q9Y3V0
resolver
uniprot_entry
A8K3Z6_HUMAN
resolver
uniprot_entry
APC13_HUMAN
resolver
uniprot_sec
A6NJK6
resolver
uniprot_sec
D3DND5
resolver
uniprot_sec
Q9Y3V0
resolver
amino_acid_sequence
MDSEVQRDGRILDLIDDAWREDKLPYEDVAIPLNELPEPEQDNGGTTESVKEQEMKWTDLALQYLHENVPPIGN
uniprot
proteins
function
FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (PubMed:15060174, PubMed:18485873, PubMed:27120157, PubMed:27509861). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (PubMed:15060174, PubMed:18485873). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (PubMed:29033132). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (PubMed:27120157, PubMed:27509861). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (PubMed:27509861). {ECO:0000269|PubMed:15060174, ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:27120157, ECO:0000269|PubMed:27509861, ECO:0000269|PubMed:29033132}.
uniprot
proteins
mass_dalton
8521
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:15060174, ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:29033132}.
uniprot
proteins
protein_family
APC13 family
uniprot
proteins
pubmed
15060174
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16364912
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18485873
uniprot
proteins
pubmed
25043029
uniprot
proteins
pubmed
26083744
uniprot
proteins
pubmed
27120157
uniprot
proteins
pubmed
27509861
uniprot
proteins
pubmed
29033132
uniprot
proteins
sequence_length
74
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins