Fermt3
entrez
108101
canonical
uniprot
Q8K1B8
canonical
ensembl
ENSMUSG00000024965
resolver
ensp
ENSMUSP00000037858
resolver
ensp
ENSMUSP00000310474
resolver
enst
ENSMUST00000040772
resolver
genesymbol
Fermt3
resolver
genesymbol_syn
BC032204
resolver
genesymbol_syn
Kind3
resolver
genesymbol_syn
Urp2
resolver
uniprot
Q3TEE6
resolver
uniprot_entry
Q3TEE6_MOUSE
resolver
uniprot_entry
URP2_MOUSE
resolver
amino_acid_sequence
MAGMKTASGDYIDSSWELRVFVGEEDPEAQSVTLRVTGESHIGGVLLKIVEEINRKQDWSDHAIWWEQKRQWLLQTHWTLDKYGILADARLFFGPQHRPVILRLPNRRVLRLRASFSKPLFQTVAAICRLLSIRHPEELSLLRAPEKKEKKKKEKEPEEEVHDLTKVVLAGGVAPTLFRGMPAHFSDSAQTEACYHMLSRPQPAPDPLLLQRLPRPSSLPDKTQLHSRWLDSSRCLMQQGIKAGDVLWLRFKYYSFFDLDPKTDPVRLTQLYEQARWDLLTEEIDCTEEEMMVFAALQYHINKLTLSGDVGELASGDLGLDDLDAALNNLEVKLKGSAPSDMLDSLTTIPELKDHLRIFRPRKLTLKGYRQYWVVFKDTTLSYYKSQDEAPGDPTQQLNLKGCEVVPDVNVSGQKFCIKLLVPSPEGMSEIYLRCQDEQQYAQWMAACRLASKGRTMADSSYASEVQAILAFLSLQRAGGSNGGSGNKPQGPEAPAEGLNPYGLVAPRFQRKFKAKQLTPRILEAHQNVAQLSLTEAQLRFIQAWQSLPDFGISYVMVRFKGSRKDEILGIANNRLIRIDLAVGDVVKTWRFSNMRQWNVNWDIRQVAIEFDEHINVAFSCVSASCRIVHEYIGGYIFLSTRERARGEELDEDLFLQLTGGHEAF
uniprot
proteins
function
FUNCTION: Plays a central role in cell adhesion in hematopoietic cells (By similarity). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (PubMed:18278053). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234461). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (PubMed:18278053). {ECO:0000250|UniProtKB:Q86UX7, ECO:0000269|PubMed:18278053, ECO:0000269|PubMed:18662549, ECO:0000269|PubMed:19234461}.
uniprot
proteins
mass_dalton
75635
uniprot
proteins
mutagenesis
MUTAGEN 597; /note="Q->A: Impairs ability to activate integrins."; /evidence="ECO:0000269|PubMed:18278053
uniprot
proteins
protein_family
Kindlin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16876785
uniprot
proteins
pubmed
18278053
uniprot
proteins
pubmed
18662549
uniprot
proteins
pubmed
19234461
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
665
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, podosome {ECO:0000269|PubMed:16876785}. Note=Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells.
uniprot
proteins