Adh4
entrez
26876
canonical
uniprot
Q9QYY9
canonical
ensembl
ENSMUSG00000037797
resolver
ensp
ENSMUSP00000013458
resolver
enst
ENSMUST00000013458
resolver
genesymbol
Adh4
resolver
genesymbol_syn
Adh2
resolver
uniprot
Q3V0P5
resolver
uniprot_entry
ADH4_MOUSE
resolver
uniprot_sec
Q3V0P5
resolver
activity_regulation
ACTIVITY REGULATION: Oxidation of 20-HETE is inhibited by low concentrations of N-heptylformamide (PubMed:16081420). Oxidation of 20-HETE is a decreased by 55-65% by either all-trans-retinol or all-trans-retinoic acid (PubMed:16081420). Strongly inhibited by omega-hydroxy fatty acids (PubMed:10514444). {ECO:0000269|PubMed:10514444, ECO:0000269|PubMed:16081420}.
uniprot
proteins
amino_acid_sequence
MGTQGKVIKCKAAIAWKTGSPLCIEEIEVSPPKACEVRIQVIATCVCPTDINATDPKKKALFPVVLGHECAGIVESVGPGVTNFKPGDKVIPFFAPQCKRCKLCLSPLTNLCGKLRNFKYPTIDQELMEDRTSRFTCKGRSIYHFMGVSSFSQYTVVSEANLARVDDEANLERVCLIGCGFSSGYGAAINTAKVTPSSTCAVFGLGCVGLSAIIGCKIAGASRIIAIDINGEKFPKAKALGATDCLNPRELDKPVQDVITELTAGGVDYSLDCAGTAQTLKAAVDCTVLGWGSCTVVGAKVDKMTIPTVDVILGRSINGTFFGGWKSVDSVPNLVSDYKNKKFDLDLLVTHALPFESINDAIDLMKEGKSIRTILTF
uniprot
proteins
ec_number
1.1.1.105
uniprot
proteins
function
FUNCTION: Catalyzes the NAD-dependent oxidation of either all-trans-retinol or 9-cis-retinol (PubMed:17279314). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (PubMed:16081420). Also catalyzes the reduction of benzoquinones (By similarity). {ECO:0000250|UniProtKB:P08319, ECO:0000269|PubMed:16081420, ECO:0000269|PubMed:17279314}.
uniprot
proteins
mass_dalton
40211
uniprot
proteins
mutagenesis
MUTAGEN 48; /note="P->H: Strongly increases NAD-retinol dehydrogenase activity."; /evidence="ECO:0000269|PubMed:10514444, ECO:0000269|PubMed:17279314"; MUTAGEN 52; /note="N->H: No effect."; /evidence="ECO:0000269|PubMed:10514444"; MUTAGEN 183; /note="S->T: Strongly increases activity towards ethanol, increases KM for benzoquinone 10-fold."; /evidence="ECO:0000269|PubMed:10514444
uniprot
proteins
protein_family
Class-II subfamily
uniprot
proteins
protein_family
Zinc-containing alcohol dehydrogenase family
uniprot
proteins
pubmed
10514444
uniprot
proteins
pubmed
10970744
uniprot
proteins
pubmed
16081420
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17279314
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
377
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins