RBBP9
entrez
10741
canonical
uniprot
O75884
canonical
ensembl
ENSG00000089050
resolver
ensp
ENSP00000336866
resolver
genesymbol
RBBP9
resolver
genesymbol_syn
BOG
resolver
genesymbol_syn
RBBP10
resolver
hgnc
HGNC:9892
resolver
uniprot
D3DW31
resolver
uniprot
Q5JPH9
resolver
uniprot
Q9H1D8
resolver
uniprot_entry
RBBP9_HUMAN
resolver
uniprot_sec
D3DW31
resolver
uniprot_sec
Q5JPH9
resolver
uniprot_sec
Q9H1D8
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by the natural product emetine produced by the ipecac root. {ECO:0000269|PubMed:19329999}.
uniprot
proteins
amino_acid_sequence
MASPSKAVIVPGNGGGDVTTHGWYGWVKKELEKIPGFQCLAKNMPDPITARESIWLPFMETELHCDEKTIIIGHSSGAIAAMRYAETHRVYAIVLVSAYTSDLGDENERASGYFTRPWQWEKIKANCPYIVQFGSTDDPFLPWKEQQEVADRLETKLHKFTDCGHFQNTEFHELITVVKSLLKVPA
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: Serine hydrolase (Probable) (PubMed:32196348). Catalyzes the hydrolytic activation of amino acid ester of the antiviral prodrug valacyclovir to its corresponding active drug, acyclovir (PubMed:32196348). May negatively regulate basal or autocrine TGF-beta signaling by suppressing SMAD2-SMAD3 phosphorylation (PubMed:20080647). May play a role in the transformation process due to its capacity to confer resistance to the growth-inhibitory effects of TGF-beta through interaction with RB1 and the subsequent displacement of E2F1 (PubMed:9697699). {ECO:0000269|PubMed:19329999, ECO:0000269|PubMed:20080647, ECO:0000269|PubMed:32196348, ECO:0000269|PubMed:9697699, ECO:0000305|PubMed:19329999, ECO:0000305|PubMed:20080647}.
uniprot
proteins
mass_dalton
21000
uniprot
proteins
mutagenesis
MUTAGEN 75; /note="S->A: Loss of serine hydrolase activity. Fails to block TGF-beta-mediated anti-proliferative signal in tumor cells."; /evidence="ECO:0000269|PubMed:19329999, ECO:0000269|PubMed:20080647
uniprot
proteins
protein_family
RBBP9 family
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12296629
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19004028
uniprot
proteins
pubmed
19329999
uniprot
proteins
pubmed
20080647
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21689726
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
32196348
uniprot
proteins
pubmed
9697699
uniprot
proteins
sequence_length
186
uniprot
proteins