SYNGR2
entrez
9144
canonical
uniprot
O43760
canonical
ensembl
ENSG00000108639
resolver
ensp
ENSP00000225777
resolver
ensp
ENSP00000466204
resolver
ensp
ENSP00000467600
resolver
enst
ENST00000589168
resolver
genesymbol
SYNGR2
resolver
hgnc
HGNC:11499
resolver
uniprot
K7ELS8
resolver
uniprot
O43762
resolver
uniprot
Q3KQZ2
resolver
uniprot
Q658S7
resolver
uniprot_entry
K7ELS8_HUMAN
resolver
uniprot_entry
SNG2_HUMAN
resolver
uniprot_sec
O43762
resolver
uniprot_sec
Q3KQZ2
resolver
uniprot_sec
Q658S7
resolver
amino_acid_sequence
MESGAYGAAKAGGSFDLRRFLTQPQVVARAVCLVFALIVFSCIYGEGYSNAHESKQMYCVFNRNEDACRYGSAIGVLAFLASAFFLVVDAYFPQISNATDRKYLVIGDLLFSALWTFLWFVGFCFLTNQWAVTNPKDVLVGADSVRAAITFSFFSIFSWGVLASLAYQRYKAGVDDFIQNYVDPTPDPNTAYASYPGASVDNYQQPPFTQNAETTEGYQPPPVY
uniprot
proteins
function
FUNCTION: May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane. {ECO:0000250|UniProtKB:O54980}.; FUNCTION: (Microbial infection) May play a role in the assembly of cytoplasmic inclusion bodies required for SFTS phlebovirus replication. {ECO:0000269|PubMed:27226560}.
uniprot
proteins
mass_dalton
24810
uniprot
proteins
post_translational_modification
PTM: May be tyrosine phosphorylated by Src. {ECO:0000250|UniProtKB:O54980}.
uniprot
proteins
protein_family
Synaptogyrin family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
27226560
uniprot
proteins
pubmed
9760194
uniprot
proteins
sequence_length
224
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:O54980}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:O54980}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to cytoplasmic vesicles associated with the recycling endosomes. {ECO:0000250|UniProtKB:O54980}.; SUBCELLULAR LOCATION: Lipid droplet. Note=(Microbial infection) Upon SFTS phlebovirus infection, the protein localizes in lipid droplets and inclusion bodies. {ECO:0000269|PubMed:27226560}.
uniprot
proteins
transmembrane_region
TRANSMEM 26..46; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 73..93; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 105..125; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 147..167; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins