GRK6
entrez
2870
canonical
uniprot
P43250
canonical
ensembl
ENSG00000198055
resolver
ensp
ENSP00000347655
resolver
ensp
ENSP00000348230
resolver
genesymbol
GRK6
resolver
genesymbol_syn
GPRK6
resolver
hgnc
HGNC:4545
resolver
uniprot
B3KPS5
resolver
uniprot
O60541
resolver
uniprot
Q13652
resolver
uniprot_entry
B3KPS5_HUMAN
resolver
uniprot_entry
GRK6_HUMAN
resolver
uniprot_sec
O60541
resolver
uniprot_sec
Q13652
resolver
amino_acid_sequence
MELENIVANTVLLKAREGGGGNRKGKSKKWRQMLQFPHISQCEELRLSLERDYHSLCERQPIGRLLFREFCATRPELSRCVAFLDGVAEYEVTPDDKRKACGRQLTQNFLSHTGPDLIPEVPRQLVTNCTQRLEQGPCKDLFQELTRLTHEYLSVAPFADYLDSIYFNRFLQWKWLERQPVTKNTFRQYRVLGKGGFGEVCACQVRATGKMYACKKLEKKRIKKRKGEAMALNEKQILEKVNSRFVVSLAYAYETKDALCLVLTLMNGGDLKFHIYHMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLAVHVPEGQTIKGRVGTVGYMAPEVVKNERYTFSPDWWALGCLLYEMIAGQSPFQQRKKKIKREEVERLVKEVPEEYSERFSPQARSLCSQLLCKDPAERLGCRGGSAREVKEHPLFKKLNFKRLGAGMLEPPFKPDPQAIYCKDVLDIEQFSTVKGVELEPTDQDFYQKFATGSVPIPWQNEMVETECFQELNVFGLDGSVPPDLDWKGQPPAPPKKGLLQRLFSRQDCCGNCSDSEEELPTRL
uniprot
proteins
ec_number
2.7.11.16
uniprot
proteins
function
FUNCTION: Specifically phosphorylates the activated forms of G protein-coupled receptors (PubMed:19423652, PubMed:20048153). Such receptor phosphorylation initiates beta-arrestin-mediated receptor internalization, and signaling events leading to their desensitization (PubMed:19423652, PubMed:20048153). Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (PubMed:20048153). Phosphorylates rhodopsin (RHO) (in vitro) and a non G protein-coupled receptor: LRP6 during Wnt signaling (in vitro) (PubMed:19801552). {ECO:0000269|PubMed:19423652, ECO:0000269|PubMed:19801552, ECO:0000269|PubMed:20048153}.
uniprot
proteins
mass_dalton
65991
uniprot
proteins
mutagenesis
MUTAGEN 6; /note="I->A: 12-13 fold defects in kinase activity; 180-fold defects in kinase activity; when associated with A-7."; /evidence="ECO:0000269|PubMed:20729810"; MUTAGEN 7; /note="V->A: 12-13 fold defects in kinase activity; 180-fold defects in kinase activity; when associated with A-6."; /evidence="ECO:0000269|PubMed:20729810"; MUTAGEN 9; /note="N->A: 140-fold defects in kinase activity."; /evidence="ECO:0000269|PubMed:20729810"; MUTAGEN 12; /note="L->A: 1100-fold defects in kinase activity."; /evidence="ECO:0000269|PubMed:20729810"; MUTAGEN 561; /note="C->S: Abolishes palmitoylation; when associated with S-562 and S-565."; /evidence="ECO:0000269|PubMed:7961702"; MUTAGEN 562; /note="C->S: Abolishes palmitoylation; when associated with S-561 and S-565."; /evidence="ECO:0000269|PubMed:7961702"; MUTAGEN 565; /note="C->S: Abolishes palmitoylation; when associated with S-561 and S-562."; /evidence="ECO:0000269|PubMed:7961702
uniprot
proteins
post_translational_modification
PTM: It is uncertain whether palmitoylation is on Cys-561 and/or Cys-562 and/or Cys-565. {ECO:0000269|PubMed:7961702}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
GPRK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10506199
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16613860
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19423652
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19801552
uniprot
proteins
pubmed
20048153
uniprot
proteins
pubmed
20729810
uniprot
proteins
pubmed
7961702
uniprot
proteins
pubmed
8366096
uniprot
proteins
pubmed
8415712
uniprot
proteins
sequence_length
576
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Lipid-anchor.
uniprot
proteins