Akr1d1
entrez
192242
canonical
uniprot
P31210
canonical
ensembl
ENSRNOG00000013004
resolver
ensp
ENSRNOP00000075542
resolver
ensp
ENSRNOP00000080261
resolver
ensp
ENSRNOP00000111180
resolver
enst
ENSRNOT00000083672
resolver
enst
ENSRNOT00000103598
resolver
enst
ENSRNOT00000161889
resolver
genesymbol
Akr1d1
resolver
uniprot
A0A0G2KAV5
resolver
uniprot
A0A8I5ZSN6
resolver
uniprot
A0ABK0LZM3
resolver
uniprot_entry
A0A0G2KAV5_RAT
resolver
uniprot_entry
A0A8I5ZSN6_RAT
resolver
uniprot_entry
A0ABK0LZM3_RAT
resolver
uniprot_entry
AK1D1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Subject to inhibition by high substrate concentrations. Inhibited by testosterone concentrations above 10 uM. Inhibited by the primary and secondary bile acids chenodeoxycholic acid and ursodeoxycholic acid. {ECO:0000250|UniProtKB:P51857}.
uniprot
proteins
amino_acid_sequence
MNLSTANHHIPLNDGNSIPIIGLGTYSDPRPVPGKTFIAVKTAIDEGYRHIDGAYVYRNEHEVGEAIREKVAEGKVKREEIFYCGKLWSTDHDPEMVRPALERTLQTLKLDYIDLYIIEMPMAFKPGEEFYPKDENGRVIYHKSNLCATWEALEACKDAGLVKSLGVSNFNRRQLEVILNKPGLKYKPVTNQVECHPYFTQTKLLEVSASSMTSFIVAYSPLGTCRNPLWVNVSSPPLLKDELLTSLGKKYNKTQAQIVLRFDIQRGLVVIPKSTTPERIKENFQIFDFSLTKEEMKDIEALNKNVRFVEMLMWSDHPEYPFHDEY
uniprot
proteins
ec_number
1.3.1.3
uniprot
proteins
function
FUNCTION: Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta-hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3-one). {ECO:0000250|UniProtKB:P51857}.
uniprot
proteins
mass_dalton
37378
uniprot
proteins
post_translational_modification
PTM: The N-terminus is blocked.
uniprot
proteins
protein_family
Aldo/keto reductase family
uniprot
proteins
pubmed
1710579
uniprot
proteins
pubmed
1789929
uniprot
proteins
pubmed
8550030
uniprot
proteins
sequence_length
326
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P51857}.
uniprot
proteins