Clk3
entrez
102414
canonical
uniprot
O35492
canonical
ensembl
ENSMUSG00000032316
resolver
ensp
ENSMUSP00000067341
resolver
ensp
ENSMUSP00000240068
resolver
ensp
ENSMUSP00000240080
resolver
ensp
ENSMUSP00000240081
resolver
ensp
ENSMUSP00000240082
resolver
ensp
ENSMUSP00000240096
resolver
enst
ENSMUST00000065330
resolver
genesymbol
Clk3
resolver
uniprot
A0A8Z1S2G3
resolver
uniprot
Q3TJU0
resolver
uniprot
Q3UIF5
resolver
uniprot
Q3V463
resolver
uniprot
Q5U4I1
resolver
uniprot
Q8C1V1
resolver
uniprot_entry
A0A8Z1S2G3_MOUSE
resolver
uniprot_entry
CLK3_MOUSE
resolver
uniprot_sec
Q3TJU0
resolver
uniprot_sec
Q3UIF5
resolver
uniprot_sec
Q3V463
resolver
uniprot_sec
Q5U4I1
resolver
uniprot_sec
Q8C1V1
resolver
activity_regulation
ACTIVITY REGULATION: Leucettine L41 inhibits its kinase activity and affects the regulation of alternative splicing mediated by phosphorylation of SR proteins. {ECO:0000269|PubMed:21615147}.
uniprot
proteins
amino_acid_sequence
MHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRIPYQRRYREHRDSDTYRCEERSPSFGEDCYGSSRSRHRRRSRERAPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHSSRNPSR
uniprot
proteins
ec_number
2.7.12.1
uniprot
proteins
function
FUNCTION: Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. {ECO:0000269|PubMed:9307018}.
uniprot
proteins
mass_dalton
58499
uniprot
proteins
post_translational_modification
PTM: Autophosphorylates on all three types of residues. {ECO:0000269|PubMed:9307018}.
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Lammer subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10585269
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21615147
uniprot
proteins
pubmed
9307018
uniprot
proteins
sequence_length
490
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cytoplasmic vesicle, secretory vesicle, acrosome.
uniprot
proteins