Fzd10
entrez
93897
canonical
uniprot
Q8BKG4
canonical
ensembl
ENSMUSG00000081683
resolver
ensp
ENSMUSP00000114114
resolver
enst
ENSMUST00000117102
resolver
genesymbol
Fzd10
resolver
genesymbol_syn
Fz10
resolver
uniprot
Q149J3
resolver
uniprot_entry
FZD10_MOUSE
resolver
uniprot_entry
Q149J3_MOUSE
resolver
amino_acid_sequence
MQHPGPRLWLVLQVMIGSCTAISSMDLERPGDGKCQPVEIPMCKDIGYNTTRMPNLMGHENQREAAIQLHEFAPLVEYGCHSHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFKFRWPDSLDCSKLPNKNDPNYLCMEAPNNGSDEPSRGSGMFPPLFRPQRPHSAQEHPLKDGGPGRAGCDNPGKFHHVEKSESCAPLCTPGVDVYWSRDDKRFAVVWLAIWSVLCFFSSAFTVLTFLIDPSRFRYPERPIIFLSMCYCVYSVGYIIRLFAGAESIACDRDSGQLYVIQEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLVPLACYLVIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGVFSLLYTVPATCVIACYFYERLNMDYWKMLATQHKCKMNNQTKTPDCLMTTSIPAVEVFMVKVSMLLVVGITSGVWVWTSKTLQSWQHVCSRGLKRKSRRKPASVVTSAGIYKKAQHPQKPHLGKYELPAQPSACV
uniprot
proteins
function
FUNCTION: Receptor for Wnt proteins (PubMed:15923619). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:15923619). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). {ECO:0000269|PubMed:15923619}.
uniprot
proteins
mass_dalton
65318
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. {ECO:0000250}.
uniprot
proteins
protein_family
G protein-coupled receptor Fz/Smo family
uniprot
proteins
pubmed
14758554
uniprot
proteins
pubmed
15923619
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
582
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15923619}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 227..247; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 264..284; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 313..333; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 353..373; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 395..415; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 445..465; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 504..524; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins