Htr1a
entrez
15550
canonical
uniprot
Q64264
canonical
ensembl
ENSMUSG00000021721
resolver
ensp
ENSMUSP00000022235
resolver
enst
ENSMUST00000022235
resolver
genesymbol
Htr1a
resolver
genesymbol_syn
Gpcr18
resolver
uniprot
Q60956
resolver
uniprot
Q61617
resolver
uniprot
Q8BGS4
resolver
uniprot_entry
5HT1A_MOUSE
resolver
uniprot_sec
Q60956
resolver
uniprot_sec
Q61617
resolver
uniprot_sec
Q8BGS4
resolver
activity_regulation
ACTIVITY REGULATION: G protein-coupled receptor activity is regulated by lipids: phosphatidylinositol 4-phosphate increases HTR1A-mediated activity (By similarity). Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli (PubMed:11080193, PubMed:17543467, PubMed:18599790, PubMed:21508226, PubMed:8254366, PubMed:9826725). {ECO:0000250|UniProtKB:P08908, ECO:0000269|PubMed:11080193, ECO:0000269|PubMed:17543467, ECO:0000269|PubMed:18599790, ECO:0000269|PubMed:21508226, ECO:0000269|PubMed:8254366, ECO:0000269|PubMed:9826725}.
uniprot
proteins
amino_acid_sequence
MDMFSLGQGNNTTTSLEPFGTGGNDTGLSNVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSNPNECTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKKGAGTSFGTSSAPPPKKSLNGQPGSGDCRRSAENRAVGTPCANGAVRQGEDDATLEVIEVHRVGNSKGHLPLPSESGATSYVPACLERKNERTAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPELLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCR
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:11080193, PubMed:17543467, PubMed:18599790, PubMed:21508226, PubMed:8254366, PubMed:9826725). Also functions as a receptor for various drugs and psychoactive substances (PubMed:11080193, PubMed:17543467, PubMed:18599790, PubMed:21508226, PubMed:8254366, PubMed:9826725). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (By similarity). HTR1A is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission: signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores (By similarity). Beta-arrestin family members regulate signaling by mediating both receptor desensitization and resensitization processes (By similarity). {ECO:0000250|UniProtKB:P08908, ECO:0000269|PubMed:11080193, ECO:0000269|PubMed:17543467, ECO:0000269|PubMed:18599790, ECO:0000269|PubMed:21508226, ECO:0000269|PubMed:8254366, ECO:0000269|PubMed:9826725}.
uniprot
proteins
mass_dalton
46176
uniprot
proteins
protein_family
5-hydroxytryptamine receptor subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
HTR1A sub-subfamily
uniprot
proteins
pubmed
11080193
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17543467
uniprot
proteins
pubmed
18599790
uniprot
proteins
pubmed
21508226
uniprot
proteins
pubmed
8254366
uniprot
proteins
pubmed
8288218
uniprot
proteins
pubmed
8626793
uniprot
proteins
pubmed
9826725
uniprot
proteins
sequence_length
421
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8254366}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P08908}. Cell projection, dendrite {ECO:0000250|UniProtKB:P19327}.
uniprot
proteins
transmembrane_region
TRANSMEM 39..59; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P08908"; TRANSMEM 74..98; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P08908"; TRANSMEM 108..132; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P08908"; TRANSMEM 153..174; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P08908"; TRANSMEM 194..216; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P08908"; TRANSMEM 347..370; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P08908"; TRANSMEM 379..403; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P08908
uniprot
proteins