ATF5
entrez
22809
canonical
uniprot
Q9Y2D1
canonical
ensembl
ENSG00000169136
resolver
ensp
ENSP00000396954
resolver
ensp
ENSP00000470633
resolver
ensp
ENSP00000528091
resolver
ensp
ENSP00000528092
resolver
ensp
ENSP00000528093
resolver
ensp
ENSP00000528094
resolver
ensp
ENSP00000528095
resolver
enst
ENST00000423777
resolver
enst
ENST00000595125
resolver
enst
ENST00000858032
resolver
enst
ENST00000858033
resolver
enst
ENST00000858034
resolver
enst
ENST00000858035
resolver
enst
ENST00000858036
resolver
genesymbol
ATF5
resolver
genesymbol_syn
ATFX
resolver
hgnc
HGNC:790
resolver
uniprot
B3KND3
resolver
uniprot
Q9BSA1
resolver
uniprot
Q9UNQ3
resolver
uniprot_entry
ATF5_HUMAN
resolver
uniprot_sec
B3KND3
resolver
uniprot_sec
Q9BSA1
resolver
uniprot_sec
Q9UNQ3
resolver
amino_acid_sequence
MSLLATLGLELDRALLPASGLGWLVDYGKLPPAPAPLAPYEVLGGALEGGLPVGGEPLAGDGFSDWMTERVDFTALLPLEPPLPPGTLPQPSPTPPDLEAMASLLKKELEQMEDFFLDAPPLPPPSPPPLPPPPLPPAPSLPLSLPSFDLPQPPVLDTLDLLAIYCRNEAGQEEVGMPPLPPPQQPPPPSPPQPSRLAPYPHPATTRGDRKQKKRDQNKSAALRYRQRKRAEGEALEGECQGLEARNRELKERAESVEREIQYVKDLLIEVYKARSQRTRSC
uniprot
proteins
function
FUNCTION: Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation (PubMed:10373550, PubMed:15358120, PubMed:20654631, PubMed:21212266). Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4 (PubMed:15358120). Important regulator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons. Must be down-regulated in order for such cells to exit the cycle and differentiate (By similarity). Participates in the pathways by which SHH promotes cerebellar granule neuron progenitor cells proliferation (By similarity). Critical for survival of mature olfactory sensory neurons (OSN), directs expression of OSN-specific genes (By similarity). May be involved in osteogenic differentiation (PubMed:22442021). Promotes cell proliferation and survival by inducing the expression of EGR1 sinergistically with ELK1. Once acetylated by EP300, binds to ARE sequences on target genes promoters, such as BCL2 and EGR1 (PubMed:21791614). Plays an anti-apoptotic role through the transcriptional regulation of BCL2, this function seems to be cell type-dependent (By similarity). Cooperates with NR1I3/CAR in the transcriptional activation of CYP2B6 in liver (PubMed:18332083). In hepatic cells, represses CRE-dependent transcription and inhibits proliferation by blocking at G2/M phase (PubMed:18701499, PubMed:22528486). May act as a negative regulator of IL1B transduction pathway in liver (PubMed:24379400). Upon IL1B stimulus, cooperates with NLK to activate the transactivation activity of C/EBP subfamily members (PubMed:25512613). Besides its function of transcription factor, acts as a cofactor of CEBPB to activate CEBPA and promote adipocyte differentiation (PubMed:24216764). Regulates centrosome dynamics in a cell-cycle- and centriole-age-dependent manner. Forms 9-foci symmetrical ring scaffold around the mother centriole to control centrosome function and the interaction between centrioles and pericentriolar material (PubMed:26213385). {ECO:0000250|UniProtKB:O70191, ECO:0000250|UniProtKB:Q6P788, ECO:0000269|PubMed:10373550, ECO:0000269|PubMed:15358120, ECO:0000269|PubMed:18332083, ECO:0000269|PubMed:18701499, ECO:0000269|PubMed:20654631, ECO:0000269|PubMed:21212266, ECO:0000269|PubMed:21791614, ECO:0000269|PubMed:22442021, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:24216764, ECO:0000269|PubMed:24379400, ECO:0000269|PubMed:25512613, ECO:0000269|PubMed:26213385}.
uniprot
proteins
mass_dalton
30674
uniprot
proteins
mutagenesis
MUTAGEN 3..25; /note="LLATLGLELDRALLPASGLGWLV->AAATAGAEADRAAAPASGAGWAA: Highly increases protein levels. No effect on protein stability enhanced by IL1B."; /evidence="ECO:0000269|PubMed:24379400"; MUTAGEN 3..4; /note="LL->AA: Increases protein levels. No effect on protein stability enhanced by IL1B."; /evidence="ECO:0000269|PubMed:24379400"; MUTAGEN 3..4; /note="LL->II: Decreases protein levels."; /evidence="ECO:0000269|PubMed:24379400"; MUTAGEN 3..4; /note="LL->VV: No effect on protein levels. No effect on protein stability enhanced by IL1B."; /evidence="ECO:0000269|PubMed:24379400"; MUTAGEN 7; /note="L->A: Increases protein levels."; /evidence="ECO:0000269|PubMed:24379400"; MUTAGEN 9..11; /note="LEL->AEA: Increases protein levels."; /evidence="ECO:0000269|PubMed:24379400"; MUTAGEN 15..16; /note="LL->AA: Increases protein levels."; /evidence="ECO:0000269|PubMed:24379400"; MUTAGEN 21..25; /note="LGWLV->AGWAA: Increases protein levels."; /evidence="ECO:0000269|PubMed:24379400"; MUTAGEN 92..94; /note="SPT->APA: Not phosphorylated; when associated with A-126 and A-190."; MUTAGEN 126; /note="S->A: Not phosphorylated; when associated with 92-A--A-94 and A-190."; MUTAGEN 157; /note="D->A: Resistant to cleavage by CASP3."; /evidence="ECO:0000269|PubMed:22528486"; MUTAGEN 190; /note="S->A: Not phosphorylated; when associated with 92-A--A-94 and A-126.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by CDC34 and UBE2B in order to be degraded by the proteasome. Cisplatin inhibits ubiquitination and proteasome-mediated degradation by inhibiting the interaction with CDC34 (PubMed:18458088). Ubiquitination and degradation by the proteasome are inhibited by NLK in a kinase-independent manner (PubMed:25512613). {ECO:0000269|PubMed:10373550, ECO:0000269|PubMed:18458088, ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:25512613}.; PTM: Phosphorylated by NLK, probably at Ser-92, Thr-94, Ser-126 and Ser-190. {ECO:0000269|PubMed:25512613}.; PTM: Acetylated at Lys-29 by EP300, the acetylation enhances the interaction with CEBPB, DNA-binding and transactivation activity. {ECO:0000250|UniProtKB:O70191, ECO:0000250|UniProtKB:Q6P788}.
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
pubmed
10373550
uniprot
proteins
pubmed
11087824
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15221005
uniprot
proteins
pubmed
15358120
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18332083
uniprot
proteins
pubmed
18458088
uniprot
proteins
pubmed
18701499
uniprot
proteins
pubmed
20654631
uniprot
proteins
pubmed
21212266
uniprot
proteins
pubmed
21791614
uniprot
proteins
pubmed
22442021
uniprot
proteins
pubmed
22528486
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24216764
uniprot
proteins
pubmed
24379400
uniprot
proteins
pubmed
25512613
uniprot
proteins
pubmed
26213385
uniprot
proteins
sequence_length
282
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15358120}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:15358120, ECO:0000269|PubMed:22528486}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:26213385}. Note=Actively transported to the centrosome and accumulated in the pericentriolar material (PCM) during G1 to M phase via a microtubule-dependent mechanism. During late telophase and cytokinesis, translocates from the centrosome to the midbody. {ECO:0000269|PubMed:26213385}.
uniprot
proteins