KCNE4
entrez
23704
canonical
uniprot
Q8WWG9
canonical
ensembl
ENSG00000152049
resolver
ensp
ENSP00000281830
resolver
genesymbol
KCNE4
resolver
hgnc
HGNC:6244
resolver
uniprot
A5H1P5
resolver
uniprot
B7Z275
resolver
uniprot
Q53SM4
resolver
uniprot
Q96CC4
resolver
uniprot_entry
KCNE4_HUMAN
resolver
uniprot_sec
A5H1P5
resolver
uniprot_sec
B7Z275
resolver
uniprot_sec
Q53SM4
resolver
uniprot_sec
Q96CC4
resolver
amino_acid_sequence
MHFLTIYPNCSSGVVRAQSRTEQKNPLGLDDLGIQNLGQTVSLAPAVEAASMLKMEPLNSTHPGTAASSSPLESRAAGGGSGNGNEYFYILVVMSFYGIFLIGIMLGYMKSKRREKKSSLLLLYKDEERLWGEAMKPLPVVSGLRSVQVPLMLNMLQESVAPALSCTLCSMEGDSVSSESSSPDVHLTIQEEGADDELEETSETPLNESSEGSSENIHQNS
uniprot
proteins
function
FUNCTION: Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits. KCNE4 beta subunit modulates the gating kinetics and enhances stability of the channel complex (PubMed:12096056, PubMed:19687231, PubMed:20533308, PubMed:27162025). Associates with KCNQ1/KVLTQ1 alpha subunit to inhibit potassium currents (PubMed:12096056, PubMed:19687231, PubMed:20533308, PubMed:27162025). {ECO:0000269|PubMed:12096056, ECO:0000269|PubMed:19687231, ECO:0000269|PubMed:20533308, ECO:0000269|PubMed:27162025}.; FUNCTION: [Isoform 2]: May inhibit KCNQ4-mediated potassium currents. {ECO:0000269|PubMed:27162025}.
uniprot
proteins
mass_dalton
23806
uniprot
proteins
protein_family
Potassium channel KCNE family
uniprot
proteins
pubmed
12096056
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
19687231
uniprot
proteins
pubmed
20533308
uniprot
proteins
pubmed
27162025
uniprot
proteins
sequence_length
221
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:27162025}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 87..107; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins