Maf
entrez
54267
canonical
uniprot
P54844
canonical
ensembl
ENSRNOG00000012428
resolver
ensp
ENSRNOP00000016577
resolver
ensp
ENSRNOP00000100324
resolver
ensp
ENSRNOP00000101124
resolver
enst
ENSRNOT00000016577
resolver
enst
ENSRNOT00000153831
resolver
enst
ENSRNOT00000164218
resolver
genesymbol
Maf
resolver
genesymbol_syn
Maf2
resolver
uniprot
A0ABK0KYS8
resolver
uniprot
A0ABK0LHZ6
resolver
uniprot
F1LSV1
resolver
uniprot_entry
A0ABK0KYS8_RAT
resolver
uniprot_entry
A0ABK0LHZ6_RAT
resolver
uniprot_entry
F1LSV1_RAT
resolver
uniprot_entry
MAF_RAT
resolver
amino_acid_sequence
MASELAMNNSDLPTSPLAMEYVNDFDLMKFEVKKEPVETDRIISQCGRLIAGGSLSSTPMSTPCSSVPPSPSFSAPSPASGSEQKAHLEDYYWMTGYPQQLNPEALGFSPEDAVEALISNSHQLQGGFDGYARGAQQLAAAAGAGAGASLGGSGEEMGPAAAVVSAVIAAAAAQSGGAPHYHHHHHHATGHHHHPTAGAPGAAGSASASASGAGGAGGGGPASAGGGGGGGGGGTAGAGGALHPHHAAGGLHFDDRFSDEQLVTMSVRELNRQLRGVSKEEVIRLKQKRRTLKNRGYAQSCRFKRVQQRHVLESEKNQLLQQVDHLKQEISRLVRERDAYKEKYEKLVSSGFRENCSSSDNPSSPEFFM
uniprot
proteins
function
FUNCTION: Acts as a transcriptional activator or repressor. When overexpressed, represses anti-oxidant response element (ARE)-mediated transcription. Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Binds to the ARE sites of detoxifying enzyme gene promoters. Involved in embryonic lens fiber cell development. Recruits the transcriptional coactivators CREBBP and/or EP300 to crystallin promoters leading to up-regulation of crystallin gene during lens fiber cell differentiation. Activates the expression of IL4 in T-helper 2 (Th2) cells. Increases T-cell susceptibility to apoptosis by interacting with MYB and decreasing BCL2 expression. Together with PAX6, transactivates strongly the glucagon gene promoter through the G1 element. Activates transcription of the CD13 proximal promoter in endothelial cells. Represses transcription of the CD13 promoter in early stages of myelopoiesis by affecting the ETS1 and MYB cooperative interaction. Involved in the initial chondrocyte terminal differentiation and the disappearance of hypertrophic chondrocytes during endochondral bone development. Binds to the sequence 5'-[GT]G[GC]N[GT]NCTCAGNN-3' in the L7 promoter. Binds to the T-MARE (Maf response element) sites of lens-specific alpha- and beta-crystallin gene promoters. Binds element G1 on the glucagon promoter. Binds an AT-rich region adjacent to the TGC motif (atypical Maf response element) in the CD13 proximal promoter in endothelial cells. It may interact with additional basic-zipper proteins that determine a subtype of Maf-responsive element binding (By similarity). {ECO:0000250, ECO:0000269|PubMed:9038383}.
uniprot
proteins
mass_dalton
38457
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is triggered by glucocorticoids (By similarity). {ECO:0000250}.; PTM: Phosphorylated by GSK3 and MAPK13 on serine and threonine residues. The phosphorylation status can serve to either stimulate or inhibit transcription (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
protein_family
Maf subfamily
uniprot
proteins
pubmed
9038383
uniprot
proteins
pubmed
9375588
uniprot
proteins
sequence_length
369
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:9038383}.
uniprot
proteins