Aldh2
entrez
11669
canonical
uniprot
P47738
canonical
ensembl
ENSMUSG00000029455
resolver
ensp
ENSMUSP00000031411
resolver
ensp
ENSMUSP00000142906
resolver
enst
ENSMUST00000031411
resolver
enst
ENSMUST00000129753
resolver
genesymbol
Aldh2
resolver
genesymbol_syn
Ahd-1
resolver
genesymbol_syn
Ahd1
resolver
uniprot
A0A0G2JEU1
resolver
uniprot
Q544B1
resolver
uniprot_entry
A0A0G2JEU1_MOUSE
resolver
uniprot_entry
ALDH2_MOUSE
resolver
uniprot_entry
Q544B1_MOUSE
resolver
amino_acid_sequence
MLRAALTTVRRGPRLSRLLSAAATSAVPAPNHQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGNKEDVDKAVKAARAAFQLGSPWRRMDASDRGRLLYRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEGVDKVAFTGSTEVGHLIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQENVYDEFVERSVARAKSRVVGNPFDSRTEQGPQVDETQFKKILGYIKSGQQEGAKLLCGGGAAADRGYFIQPTVFGDVKDGMTIAKEEIFGPVMQILKFKTIEEVVGRANDSKYGLAAAVFTKDLDKANYLSQALQAGTVWINCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS
uniprot
proteins
ec_number
1.2.1.19
uniprot
proteins
ec_number
1.2.1.24
uniprot
proteins
ec_number
1.2.1.3
uniprot
proteins
ec_number
1.2.1.36
uniprot
proteins
ec_number
1.2.1.46
uniprot
proteins
ec_number
1.7.1.-
uniprot
proteins
function
FUNCTION: Mitochondrial aldehyde dehydrogenase with broad substrate specificity which participates in the detoxification of ethanol-derived acetaldehyde and endogenous aldehydes, including those arising from lipid peroxidation (PubMed:8058062). The reaction mechanism involves a nucleophilic attack on the aldehyde substrate, resulting in formation of a thiohemiacetal intermediate. Subsequent hydride transfer to NAD+, yields a thioester intermediate which is hydrolyzed to the carboxylic acid product through activation of a water molecule by the catalytic glutamate. In vivo, ALDH2 is required for the clearance of formaldehyde, a cytotoxic and carcinogenic endogenous metabolite that induces DNA damage. It also catalyzes the oxidation of 3,4-dihydroxyphenylacetaldehyde (DOPAL), a reactive intermediate of dopamine catabolism, to 3,4-dihydroxyphenylacetate (DOPAC) (By similarity). ALDH2 may also catalyze the oxidation of 4-aminobutanal (gamma-aminobutyraldehyde) to 4-aminobutanoate (GABA), representing an alternative route for GABA biosynthesis from polyamine catabolism (By similarity). In vitro, ALDH2 catalyzes the oxidation of acrolein, malondialdehyde, and 4-hydroxynonenal (4-HNE). It also exhibits esterase activity that is enhanced by NAD+ but does not require it, although the physiological relevance of this activity remains unclear (By similarity). {ECO:0000250|UniProtKB:P05091, ECO:0000250|UniProtKB:P20000, ECO:0000269|PubMed:8058062}.; FUNCTION: Also denitrates nitroglycerin, generating nitric oxide (NO) by a mechanism that remains incompletely understood. {ECO:0000250|UniProtKB:P05091}.
uniprot
proteins
mass_dalton
56538
uniprot
proteins
pathway_participation
PATHWAY: Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2. {ECO:0000250|UniProtKB:P05091}.
uniprot
proteins
post_translational_modification
PTM: In response to mitochondrial stress, the precursor protein is ubiquitinated by the SIFI complex in the cytoplasm before mitochondrial import, leading to its degradation. {ECO:0000250|UniProtKB:P05091}.
uniprot
proteins
protein_family
Aldehyde dehydrogenase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
7937138
uniprot
proteins
pubmed
7958964
uniprot
proteins
pubmed
8058062
uniprot
proteins
sequence_length
519
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P05091}.
uniprot
proteins