ICOS
entrez
29851
canonical
uniprot
Q9Y6W8
canonical
ensembl
ENSG00000163600
resolver
ensp
ENSP00000319476
resolver
genesymbol
ICOS
resolver
genesymbol_syn
AILIM
resolver
hgnc
HGNC:5351
resolver
uniprot
Q53QY6
resolver
uniprot
Q8N6W8
resolver
uniprot_entry
ICOS_HUMAN
resolver
uniprot_entry
Q53QY6_HUMAN
resolver
uniprot_sec
Q8N6W8
resolver
amino_acid_sequence
MKSGLWYFFLFCLRIKVLTGEINGSANYEMFIFHNGGVQILCKYPDIVQQFKMQLLKGGQILCDLTKTKGSGNTVSIKSLKFCHSQLSNNSVSFFLYNLDHSHANYYFCNLSIFDPPPFKVTLTGGYLHIYESQLCCQLKFWLPIGCAAFVVVCILGCILICWLTKKKYSSSVHDPNGEYMFMRAVNTAKKSRLTDVTL
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency, common variable, 1 (CVID1) [MIM:607594]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. {ECO:0000269|PubMed:12577056}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Stimulatory receptor expressed in activated or antigen-experienced T-cells that plays an important role in the immune response (PubMed:9930702). Upon binding to its ligand ICOSL expressed on antigen presenting cells (APCs), delivers costimulatory signals that enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines including IL10, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells (PubMed:33033255). Also acts as a costimulatory receptor critical for the differentiation of T follicular regulatory cells upon immune challenges such as viral infection (PubMed:27135603). Mechanistically, potentiates TCR-induced calcium flux by augmenting PLCG1 activation and actin remodeling (By similarity). In addition, activates PI3K signaling pathways independently of calcium flux (PubMed:30523347). Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity). {ECO:0000250|UniProtKB:Q9WVS0, ECO:0000269|PubMed:27135603, ECO:0000269|PubMed:30523347, ECO:0000269|PubMed:33033255, ECO:0000269|PubMed:9930702}.
uniprot
proteins
mass_dalton
22625
uniprot
proteins
mutagenesis
MUTAGEN 110; /note="N->Q: About 4.3-fold improvement in binding affinity to ICOSLG."; /evidence="ECO:0000269|PubMed:33033255
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:11169414}.
uniprot
proteins
pubmed
10779774
uniprot
proteins
pubmed
11006126
uniprot
proteins
pubmed
11169414
uniprot
proteins
pubmed
11735222
uniprot
proteins
pubmed
12577056
uniprot
proteins
pubmed
12753665
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
27135603
uniprot
proteins
pubmed
30523347
uniprot
proteins
pubmed
33033255
uniprot
proteins
pubmed
9930702
uniprot
proteins
sequence_length
199
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:30523347}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 141..161; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins