MX2
entrez
4600
canonical
uniprot
P20592
canonical
ensembl
ENSG00000183486
resolver
ensp
ENSP00000333657
resolver
ensp
ENSP00000506423
resolver
ensp
ENSP00000580667
resolver
ensp
ENSP00000580668
resolver
ensp
ENSP00000580671
resolver
ensp
ENSP00000580672
resolver
ensp
ENSP00000636031
resolver
genesymbol
MX2
resolver
hgnc
HGNC:7533
resolver
uniprot
B7Z5D3
resolver
uniprot
D3DSI7
resolver
uniprot_entry
MX2_HUMAN
resolver
uniprot_sec
B7Z5D3
resolver
uniprot_sec
D3DSI7
resolver
amino_acid_sequence
MSKAHKPWPYRRRSQFSSRKYLKKEMNSFQQQPPPFGTVPPQMMFPPNWQGAEKDAAFLAKDFNFLTLNNQPPPGNRSQPRAMGPENNLYSQYEQKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKQPCEAWAGRISYRNTELELQDPGQVEKEIHKAQNVMAGNGRGISHELISLEITSPEVPDLTIIDLPGITRVAVDNQPRDIGLQIKALIKKYIQRQQTINLVVVPCNVDIATTEALSMAHEVDPEGDRTIGILTKPDLMDRGTEKSVMNVVRNLTYPLKKGYMIVKCRGQQEITNRLSLAEATKKEITFFQTHPYFRVLLEEGSATVPRLAERLTTELIMHIQKSLPLLEGQIRESHQKATEELRRCGADIPSQEADKMFFLIEKIKMFNQDIEKLVEGEEVVRENETRLYNKIREDFKNWVGILATNTQKVKNIIHEEVEKYEKQYRGKELLGFVNYKTFEIIVHQYIQQLVEPALSMLQKAMEIIQQAFINVAKKHFGEFFNLNQTVQSTIEDIKVKHTAKAENMIQLQFRMEQMVFCQDQIYSVVLKKVREEIFNPLGTPSQNMKLNSHFPSNESSVSSFTEIGIHLNAYFLETSKRLANQIPFIIQYFMLRENGDSLQKAMMQILQEKNRYSWLLQEQSETATKRRILKERIYRLTQARHALCQFSSKEIH
uniprot
proteins
function
FUNCTION: Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression. {ECO:0000269|PubMed:15184662, ECO:0000269|PubMed:24048477, ECO:0000269|PubMed:24055605, ECO:0000269|PubMed:24121441}.
uniprot
proteins
mass_dalton
82089
uniprot
proteins
mutagenesis
MUTAGEN 131; /note="K->A: Loss of GTP-binding and localization to nuclear pore. Disruption of nuclear import."; /evidence="ECO:0000269|PubMed:15184662"; MUTAGEN 151; /note="T->A: Defective GTP-hydrolysis. Disruption of nuclear import and cell-cycle progression."; /evidence="ECO:0000269|PubMed:15184662
uniprot
proteins
protein_family
Dynamin/Fzo/YdjA family
uniprot
proteins
protein_family
TRAFAC class dynamin-like GTPase superfamily
uniprot
proteins
pubmed
10830953
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15184662
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18062906
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2154602
uniprot
proteins
pubmed
24048477
uniprot
proteins
pubmed
24055605
uniprot
proteins
pubmed
24121441
uniprot
proteins
pubmed
24139395
uniprot
proteins
pubmed
2481229
uniprot
proteins
sequence_length
715
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15184662}. Nucleus {ECO:0000269|PubMed:15184662}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:15184662}. Note=Localization to nuclear pores requires GTP-binding.
uniprot
proteins