Rab9a
entrez
84589
canonical
uniprot
Q99P75
canonical
ensembl
ENSRNOG00000030443
resolver
ensembl
ENSRNOG00055029147
resolver
ensembl
ENSRNOG00060020234
resolver
ensembl
ENSRNOG00065024468
resolver
ensp
ENSRNOP00000089377
resolver
ensp
ENSRNOP00000105306
resolver
ensp
ENSRNOP00000109079
resolver
ensp
ENSRNOP00000112583
resolver
ensp
ENSRNOP00055041579
resolver
ensp
ENSRNOP00055041583
resolver
ensp
ENSRNOP00055041589
resolver
ensp
ENSRNOP00055041593
resolver
ensp
ENSRNOP00055041607
resolver
ensp
ENSRNOP00055041616
resolver
ensp
ENSRNOP00060028774
resolver
ensp
ENSRNOP00060028787
resolver
ensp
ENSRNOP00060028802
resolver
ensp
ENSRNOP00060028820
resolver
ensp
ENSRNOP00060028824
resolver
ensp
ENSRNOP00060028829
resolver
ensp
ENSRNOP00065034286
resolver
ensp
ENSRNOP00065034292
resolver
ensp
ENSRNOP00065034309
resolver
ensp
ENSRNOP00065034318
resolver
ensp
ENSRNOP00065034327
resolver
ensp
ENSRNOP00065034337
resolver
enst
ENSRNOT00000109401
resolver
enst
ENSRNOT00000128138
resolver
enst
ENSRNOT00000164607
resolver
enst
ENSRNOT00000171804
resolver
enst
ENSRNOT00055050496
resolver
enst
ENSRNOT00055050500
resolver
enst
ENSRNOT00055050506
resolver
enst
ENSRNOT00055050511
resolver
enst
ENSRNOT00055050525
resolver
enst
ENSRNOT00055050534
resolver
enst
ENSRNOT00060035022
resolver
enst
ENSRNOT00060035036
resolver
enst
ENSRNOT00060035052
resolver
enst
ENSRNOT00060035070
resolver
enst
ENSRNOT00060035074
resolver
enst
ENSRNOT00060035080
resolver
enst
ENSRNOT00065041951
resolver
enst
ENSRNOT00065041957
resolver
enst
ENSRNOT00065041974
resolver
enst
ENSRNOT00065041983
resolver
enst
ENSRNOT00065041992
resolver
enst
ENSRNOT00065042002
resolver
genesymbol
Rab9a
resolver
genesymbol_syn
Rab9
resolver
uniprot
Q6NS34
resolver
uniprot_entry
RAB9A_RAT
resolver
uniprot_sec
Q6NS34
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000250|UniProtKB:P51151}.
uniprot
proteins
amino_acid_sequence
MAGKSSLFKIILLGDGGVGKSSLMNRYVTNKFDSQLFHTIGVEFLNKDLEVDGHFVTMQIWDTAGQERFRSLRTPFYRGSDCCLLTFSVDDSQSFQNLSNWKKEFIYYADVKEPESFPFVILGNKTDIKERQVSTEEAQAWCKDNGDYPYFETSAKDSTNVAAAFEEAVRRILATEDRSDHLIQTDTVNLHRKPKPNSSCC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB9A is involved in the transport of proteins between the endosomes and the trans-Golgi network (TGN). Specifically uses NDE1/NDEL1 as an effector to interact with the dynein motor complex in order to control retrograde trafficking of RAB9-associated late endosomes to the TGN (By similarity). Involved in the recruitment of SGSM2 to melanosomes and is required for the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity). {ECO:0000250|UniProtKB:P24408, ECO:0000250|UniProtKB:P51151, ECO:0000250|UniProtKB:P62820, ECO:0000250|UniProtKB:Q9R0M6}.
uniprot
proteins
mass_dalton
22896
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
12051767
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16885419
uniprot
proteins
sequence_length
201
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P51151}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P51151}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P51151}. Late endosome {ECO:0000269|PubMed:12051767}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:P51151}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:P51151}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9R0M6}. Melanosome {ECO:0000250|UniProtKB:Q9R0M6}. Note=Colocalizes with OSBPL1A at the late endosome. Recruited to phagosomes containing S.aureus or M.tuberculosis. Mainly localizes to late endosomes and partially localizes to Golgi. Colocalizes with NDE1 to membrane vesicles (By similarity). {ECO:0000250|UniProtKB:P51151}.
uniprot
proteins