ATP6V0B
entrez
533
canonical
uniprot
Q99437
canonical
ensembl
ENSG00000117410
resolver
ensp
ENSP00000236067
resolver
ensp
ENSP00000431605
resolver
ensp
ENSP00000434094
resolver
ensp
ENSP00000434729
resolver
enst
ENST00000532642
resolver
genesymbol
ATP6V0B
resolver
genesymbol_syn
ATP6F
resolver
hgnc
HGNC:861
resolver
uniprot
D3DPY5
resolver
uniprot
E9PNL3
resolver
uniprot
Q6IB32
resolver
uniprot_entry
E9PNL3_HUMAN
resolver
uniprot_entry
VATO_HUMAN
resolver
uniprot_sec
D3DPY5
resolver
uniprot_sec
Q6IB32
resolver
amino_acid_sequence
MTGLALLYSGVFVAFWACALAVGVCYTIFDLGFRFDVAWFLTETSPFMWSNLGIGLAISLSVVGAAWGIYITGSSIIGGGVKAPRIKTKNLVSIIFCEAVAIYGIIMAIVISNMAEPFSATDPKAIGHRNYHAGYSMFGAGLTVGLSNLFCGVCVGIVGSGAALADAQNPSLFVKILIVEIFGSAIGLFGVIVAILQTSRVKMGD
uniprot
proteins
function
FUNCTION: Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:33065002). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (By similarity). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (PubMed:22053050). {ECO:0000250|UniProtKB:Q2TA24, ECO:0000269|PubMed:22053050, ECO:0000269|PubMed:33065002}.
uniprot
proteins
mass_dalton
21406
uniprot
proteins
protein_family
V-ATPase proteolipid subunit family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
22053050
uniprot
proteins
pubmed
33065002
uniprot
proteins
pubmed
9653649
uniprot
proteins
sequence_length
205
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:Q2TA24}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 52..72; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 91..111; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 138..158; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 176..196; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins