RNF14
entrez
9604
canonical
uniprot
Q9UBS8
canonical
ensembl
ENSG00000013561
resolver
ensp
ENSP00000324956
resolver
ensp
ENSP00000348462
resolver
ensp
ENSP00000378022
resolver
ensp
ENSP00000378027
resolver
ensp
ENSP00000378028
resolver
ensp
ENSP00000575459
resolver
ensp
ENSP00000575460
resolver
ensp
ENSP00000575465
resolver
ensp
ENSP00000575466
resolver
ensp
ENSP00000575467
resolver
ensp
ENSP00000575471
resolver
ensp
ENSP00000575473
resolver
ensp
ENSP00000633090
resolver
ensp
ENSP00000633094
resolver
ensp
ENSP00000767094
resolver
genesymbol
RNF14
resolver
genesymbol_syn
ARA54
resolver
hgnc
HGNC:10058
resolver
uniprot
A0AV26
resolver
uniprot
A6NMR2
resolver
uniprot
A8MTW5
resolver
uniprot
B3KN72
resolver
uniprot
B7Z229
resolver
uniprot
B7ZLV2
resolver
uniprot
D3DQE4
resolver
uniprot
O94793
resolver
uniprot
Q6IBV0
resolver
uniprot_entry
B7Z229_HUMAN
resolver
uniprot_entry
RNF14_HUMAN
resolver
uniprot_sec
A0AV26
resolver
uniprot_sec
A6NMR2
resolver
uniprot_sec
A8MTW5
resolver
uniprot_sec
B3KN72
resolver
uniprot_sec
B7ZLV2
resolver
uniprot_sec
D3DQE4
resolver
uniprot_sec
O94793
resolver
uniprot_sec
Q6IBV0
resolver
amino_acid_sequence
MSSEDREAQEDELLALASIYDGDEFRKAESVQGGETRIYLDLPQNFKIFVSGNSNECLQNSGFEYTICFLPPLVLNFELPPDYPSSSPPSFTLSGKWLSPTQLSALCKHLDNLWEEHRGSVVLFAWMQFLKEETLAYLNIVSPFELKIGSQKKVQRRTAQASPNTELDFGGAAGSDVDQEEIVDERAVQDVESLSNLIQEILDFDQAQQIKCFNSKLFLCSICFCEKLGSECMYFLECRHVYCKACLKDYFEIQIRDGQVQCLNCPEPKCPSVATPGQVKELVEAELFARYDRLLLQSSLDLMADVVYCPRPCCQLPVMQEPGCTMGICSSCNFAFCTLCRLTYHGVSPCKVTAEKLMDLRNEYLQADEANKRLLDQRYGKRVIQKALEEMESKEWLEKNSKSCPCCGTPIEKLDGCNKMTCTGCMQYFCWICMGSLSRANPYKHFNDPGSPCFNRLFYAVDVDDDIWEDEVED
uniprot
proteins
ec_number
2.3.2.31
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that plays a key role in the RNF14-RNF25 translation quality control pathway, a pathway that takes place when a ribosome has stalled during translation, and which promotes ubiquitination and degradation of translation factors on stalled ribosomes (PubMed:36638793, PubMed:37651229, PubMed:37951215, PubMed:37951216). Recruited to stalled ribosomes by the ribosome collision sensor GCN1 and mediates 'Lys-6'-linked ubiquitination of target proteins, leading to their degradation (PubMed:36638793, PubMed:37651229, PubMed:37951215, PubMed:37951216). Mediates ubiquitination of EEF1A1/eEF1A and ETF1/eRF1 translation factors on stalled ribosomes, leading to their degradation (PubMed:36638793, PubMed:37651229). Also catalyzes ubiquitination of ribosomal proteins RPL0, RPL1, RPL12, RPS13 and RPS17 (PubMed:36638793). Specifically required to resolve RNA-protein cross-links caused by reactive aldehydes, which trigger translation stress by stalling ribosomes: acts by catalying 'Lys-6'-linked ubiquitination of RNA-protein cross-links, leading to their removal by the ATP-dependent unfoldase VCP and subsequent degradation by the proteasome (PubMed:37951215, PubMed:37951216). Independently of its function in the response to stalled ribosomes, acts as a regulator of transcription in Wnt signaling via its interaction with TCF transcription factors (TCF7/TCF1, TCF7L1/TCF3 and TCF7L2/TCF4) (PubMed:23449499). May also play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription (PubMed:19345326). {ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:23449499, ECO:0000269|PubMed:36638793, ECO:0000269|PubMed:37651229, ECO:0000269|PubMed:37951215, ECO:0000269|PubMed:37951216}.
uniprot
proteins
mass_dalton
53837
uniprot
proteins
mutagenesis
MUTAGEN 220; /note="C->S: Abolished E3 ubiquitin-protein ligase activity. Loss of interaction with UBE2E2 and of autoubiquitination."; /evidence="ECO:0000269|PubMed:11322894, ECO:0000269|PubMed:37651229"; MUTAGEN 417; /note="C->A: Abolished E3 ubiquitin-protein ligase activity."; /evidence="ECO:0000269|PubMed:36638793
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:36638793, ECO:0000269|PubMed:37651229, ECO:0000269|PubMed:37951215, ECO:0000269|PubMed:37951216}.
uniprot
proteins
post_translational_modification
PTM: RING-type zinc finger-dependent and UBE2E2-dependent autoubiquitination. {ECO:0000269|PubMed:11322894}.
uniprot
proteins
protein_family
RBR family
uniprot
proteins
protein_family
RNF14 subfamily
uniprot
proteins
pubmed
10085091
uniprot
proteins
pubmed
10320776
uniprot
proteins
pubmed
11322894
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19345326
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23449499
uniprot
proteins
pubmed
36638793
uniprot
proteins
pubmed
37651229
uniprot
proteins
pubmed
37951215
uniprot
proteins
pubmed
37951216
uniprot
proteins
pubmed
9853615
uniprot
proteins
sequence_length
474
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9853615}. Nucleus {ECO:0000269|PubMed:9853615}.
uniprot
proteins