Men1
entrez
29417
canonical
uniprot
Q9WVR8
canonical
ensembl
ENSRNOG00000021054
resolver
ensembl
ENSRNOG00055022337
resolver
ensembl
ENSRNOG00060032676
resolver
ensembl
ENSRNOG00065029138
resolver
ensp
ENSRNOP00000028592
resolver
ensp
ENSRNOP00000076697
resolver
enst
ENSRNOT00000028592
resolver
genesymbol
Men1
resolver
uniprot
A0A8L2QI00
resolver
uniprot
D3ZCA2
resolver
uniprot_entry
A0A8L2QI00_RAT
resolver
uniprot_entry
MEN1_RAT
resolver
uniprot_sec
D3ZCA2
resolver
amino_acid_sequence
MGLKAAQKTLFPLRSIDDVVRLFAAELGREEPDLVLLSLVLGFVEHFLAVNRVIPTNVPELTFQPSPAPDPPGGLTYFPVADLSIIAALYARFTAQIRGAVDLSLYPREGGVSSRELVKKVSDVIWNSLSRSYFKDRAHIQSLFSFITGTKLDSSGVAFAVVGACQALGLRDVHLALSEDHAWVVFGSNGEQTAEVTWHGKGNEDRRGQTVNAGVAERSWLYLKGSYMRCDRKMEVAFMVCAINPSIDLHTDSLELLQLQQKLLWLLYDLGHLERYPMALGNLADLEELEPTPGRPDPLTLYHKGIASAKTYYQDEHIYPYMYLAGYHCRNRNVREALQAWADTATVIQDYNYCREDEEIYKEFFEVANDVIPNLLKEAASLLEAGEERPGEQAQGTQGQGSALQDPECFAHLLRFYDGICKWEEGSPTPVLHVGWATFLVQSLGRFEGQVRQKVHIVSREAEAAEAEEPWGDEAREGRRRGPRRESKPEEPPPPKKPALDKGPGSGQSAGSGPPRKTSGTVSGTARGTEVSSAAQAPAPAASPPPEGPVLTFQSEKMKGMKELLVATKINSSAIKLQLTAQSQVQMKKQKVSTPSDYTLSFLKRQRKGL
uniprot
proteins
function
FUNCTION: Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression. May be involved in DNA repair (By similarity). Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. {ECO:0000250|UniProtKB:O00255, ECO:0000250|UniProtKB:O88559, ECO:0000269|PubMed:11274402}.
uniprot
proteins
mass_dalton
67335
uniprot
proteins
pubmed
10524203
uniprot
proteins
pubmed
10612420
uniprot
proteins
pubmed
11274402
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
610
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10612420}.
uniprot
proteins