KCNMB3
entrez
27094
canonical
uniprot
Q9NPA1
canonical
ensembl
ENSG00000171121
resolver
ensp
ENSP00000319370
resolver
ensp
ENSP00000327866
resolver
ensp
ENSP00000376451
resolver
ensp
ENSP00000417091
resolver
ensp
ENSP00000418536
resolver
genesymbol
KCNMB3
resolver
genesymbol_syn
KCNMB2
resolver
genesymbol_syn
KCNMBL
resolver
hgnc
HGNC:6287
resolver
uniprot
B7Z9C9
resolver
uniprot
D3DNR2
resolver
uniprot
E9PER5
resolver
uniprot
Q9NPG7
resolver
uniprot
Q9NRM9
resolver
uniprot
Q9UHN3
resolver
uniprot_entry
KCMB3_HUMAN
resolver
uniprot_sec
B7Z9C9
resolver
uniprot_sec
D3DNR2
resolver
uniprot_sec
E9PER5
resolver
uniprot_sec
Q9NPG7
resolver
uniprot_sec
Q9NRM9
resolver
uniprot_sec
Q9UHN3
resolver
amino_acid_sequence
MDFSPSSELGFHFVAFILLTRHRTAFPASGKKRETDYSDGDPLDVHKRLPSSAGEDRAVMLGFAMMGFSVLMFFLLGTTILKPFMLSIQREESTCTAIHTDIMDDWLDCAFTCGVHCHGQGKYPCLQVFVNLSHPGQKALLHYNEEAVQINPKCFYTPKCHQDRNDLLNSALDIKEFFDHKNGTPFSCFYSPASQSEDVILIKKYDQMAIFHCLFWPSLTLLGGALIVGMVRLTQHLSLLCEKYSTVVRDEVGGKVPYIEQHQFKLCIMRRSKGRAEKS
uniprot
proteins
function
FUNCTION: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer. {ECO:0000269|PubMed:10766764, ECO:0000269|PubMed:10864947}.
uniprot
proteins
mass_dalton
31604
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:10792058}.; PTM: The extracellular domain contains disulfide bond essential for the gating mechanism.
uniprot
proteins
protein_family
KCNMB (TC 8.A.14.1) family
uniprot
proteins
protein_family
KCNMB3 subfamily
uniprot
proteins
pubmed
10585773
uniprot
proteins
pubmed
10692449
uniprot
proteins
pubmed
10766764
uniprot
proteins
pubmed
10792058
uniprot
proteins
pubmed
10828459
uniprot
proteins
pubmed
10864947
uniprot
proteins
pubmed
11382808
uniprot
proteins
pubmed
11382809
uniprot
proteins
pubmed
12136044
uniprot
proteins
pubmed
12740608
uniprot
proteins
pubmed
14612589
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16641997
uniprot
proteins
sequence_length
279
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 61..81; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 208..228; /note="Helical; Name=2"; /evidence="ECO:0000255
uniprot
proteins