Fign
entrez
60344
canonical
uniprot
Q9ERZ6
canonical
ensembl
ENSMUSG00000075324
resolver
ensp
ENSMUSP00000122855
resolver
genesymbol
Fign
resolver
uniprot
Q3TPB0
resolver
uniprot
Q3UP57
resolver
uniprot
Q6PCM0
resolver
uniprot_entry
FIGN_MOUSE
resolver
uniprot_sec
Q3TPB0
resolver
uniprot_sec
Q3UP57
resolver
uniprot_sec
Q6PCM0
resolver
amino_acid_sequence
MISSTSVYGLKMQWTPEHAQWPEQHFDITSTTRSPAHKVEAYRGHLQRTYQYAWANDDISALTASNLLKKYAEKYSGILEGPVDRPVLSNYSDTPSGLVNGRKNDSEPWQPSLNSEAVYPMNCVPDVITASKAGVSSALPPVDVSASIGSSPGVASNLTEPSYSSSTCGSHTVPSLHAGLPSQEYAPGYNGSYLHSTYSSQATPALPSPHPSPLHSSGLLQPPPPPPPPPALVPGYNGTSNLSSYSYPSASYPPQTAVGSGYSPGGAPPPPSAYLPSGIPAPTPLPPTTVPGYTYQGHGLTPIAPSALTNNSASSLKRKAFYMAGQGDMDSSYGNYSYGQQRSTQSPMYRMPDNSISNSNRGNGFDRNAETSSLAFKPTKQLMPSEQQRKFSSQSSRALTPPSYSTAKNSLGSRSSESFGKYTSPVMSEHGDDHRQLLAHPIQGPGLRAATSSNHSVDEQLKNTDTHLIDLVTNEIITQGPPVDWSDIAGLDLVKAVIKEEVLWPVLRSDAFSGLTALPRSILLFGPRGTGKTLLGRCIASQLGATFFKIAGSGLVAKWIGEAEKIIHASFLVARCRQPSVIFVSDIDMLLSSQVSEEHSPVSRMRTEFLMQLDTVLTSAEDQIVVICATSKPEEIDESLRRYFMKRLLIPLPDSTARHQIIVQLLTQHNYCLNDKEFALLVQRTEGFSGLDVAHLCQEAAVGPLHAMPATDLSAIMPSQLRPVTYQDFENAFCKIQPSISQKELDMYVEWNKMFGCSQ
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Fignl1 are the cause of the 'fidget' phenotype, a spontaneous mutation characterized by a side-to-side head-shaking and circling behavior, due to reduced or absent semicircular canals (PubMed:11017077). Fidget mice also have small eyes, associated with cell-cycle delay and insufficient growth of the retinal neural epithelium, and lower penetrance skeletal abnormalities, including pelvic girdle dysgenesis, skull bone fusions and polydactyly (PubMed:11017077). {ECO:0000269|PubMed:11017077}.
uniprot
proteins
function
FUNCTION: ATP-dependent microtubule severing protein. Severs microtubules along their length and depolymerizes their ends, primarily the minus-end, suppressing microtubule growth from and attachment to centrosomes. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
82098
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
pubmed
11017077
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15707573
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16751186
uniprot
proteins
sequence_length
759
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000269|PubMed:15707573, ECO:0000269|PubMed:16751186}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Localizes to centrosomes throughout mitosis and to the spindle midzone during telophase. {ECO:0000250}.
uniprot
proteins