Has2
entrez
15117
canonical
uniprot
P70312
canonical
ensembl
ENSMUSG00000022367
resolver
ensp
ENSMUSP00000062212
resolver
enst
ENSMUST00000050544
resolver
genesymbol
Has2
resolver
uniprot
P70411
resolver
uniprot
Q62405
resolver
uniprot
Q68EF7
resolver
uniprot_entry
HYAS2_MOUSE
resolver
uniprot_sec
P70411
resolver
uniprot_sec
Q62405
resolver
uniprot_sec
Q68EF7
resolver
amino_acid_sequence
MHCERFLCVLRIIGTTLFGVSLLLGITAAYIVGYQFIQTDNYYFSFGLYGAFLASHLIIQSLFAFLEHRKMKKSLETPIKLNKTVALCIAAYQEDPDYLRKCLQSVKRLTYPGIKVVMVIDGNSDDDLYMMDIFSEVMGRDKSATYIWKNNFHEKGPGETEESHKESSQHVTQLVLSNKSICIMQKWGGKREVMYTAFRALGRSVDYVQVCDSDTMLDPASSVEMVKVLEEDPMVGGVGGDVQILNKYDSWISFLSSVRYWMAFNIERACQSYFGCVQCISGPLGMYRNSLLHEFVEDWYNQEFMGNQCSFGDDRHLTNRVLSLGYATKYTARSKCLTETPIEYLRWLNQQTRWSKSYFREWLYNAMWFHKHHLWMTYEAVITGFFPFFLIATVIQLFYRGKIWNILLFLLTVQLVGLIKSSFASCLRGNIVMVFMSLYSVLYMSSLLPAKMFAIATINKAGWGTSGRKTIVVNFIGLIPVSVWFTILLGGVIFTIYKESKKPFSESKQTVLIVGTLIYACYWVMLLTLYVVLINKCGRRKKGQQYDMVLDV
uniprot
proteins
ec_number
2.4.1.212
uniprot
proteins
function
FUNCTION: Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction and it is particularly responsible for the synthesis of high molecular mass hyaluronan (PubMed:10455188). Required for the transition of endocardial cushion cells into mesenchymal cells, a process crucial for heart development (PubMed:10930438). May also play a role in vasculogenesis. High molecular mass hyaluronan also play a role in early contact inhibition a process which stops cell growth when cells come into contact with each other or the extracellular matrix. {ECO:0000269|PubMed:10455188, ECO:0000269|PubMed:10930438}.; FUNCTION: Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation (By similarity). This is one of three isoenzymes responsible for cellular hyaluronan synthesis and it is particularly responsible for the synthesis of high molecular mass hyaluronan (PubMed:10455188). {ECO:0000250|UniProtKB:Q92819, ECO:0000269|PubMed:10455188}.
uniprot
proteins
mass_dalton
63510
uniprot
proteins
pathway_participation
PATHWAY: Glycan biosynthesis; hyaluronan biosynthesis. {ECO:0000269|PubMed:10455188}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-328 is essential for hyaluronan synthase activity. {ECO:0000250|UniProtKB:Q92819}.; PTM: O-GlcNAcylation at Ser-221 increases the stability of HAS2 and plasma membrane localization. {ECO:0000250|UniProtKB:Q92819}.; PTM: Ubiquitination at Lys-190; this ubiquitination is essential for hyaluronan synthase activity and homo- or heterooligomerization. Can also be poly-ubiquitinated. Deubiquitinated by USP17L22/USP17 and USP4. USP17L22/USP17 efficiently removes 'Lys-63'- and 'Lys-48'-linked polyubiquitin chains, whereas USP4 preferentially removes monoubiquitination and, partially, both 'Lys-63'- and 'Lys-48'-linked polyubiquitin chain. {ECO:0000250|UniProtKB:Q92819}.
uniprot
proteins
protein_family
NodC/HAS family
uniprot
proteins
pubmed
10455188
uniprot
proteins
pubmed
10930438
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
8643441
uniprot
proteins
pubmed
8798545
uniprot
proteins
pubmed
9016821
uniprot
proteins
sequence_length
552
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q92819}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q92819}; Multi-pass membrane protein {ECO:0000255}. Vesicle {ECO:0000250|UniProtKB:Q92819}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q92819}; Multi-pass membrane protein {ECO:0000255}. Lysosome {ECO:0000250|UniProtKB:Q92819}. Note=Travels from endoplasmic reticulum (ER), Golgi to plasma membrane and either back to endosomes and lysosomes, or out into extracellular vesicles. Post-translational modifications control HAS2 trafficking. {ECO:0000250|UniProtKB:Q92819}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 46..66; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 375..395; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 403..423; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 430..450; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 476..496; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 511..531; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins