Cpb2
entrez
113936
canonical
uniprot
Q9EQV9
canonical
ensembl
ENSRNOG00000010935
resolver
ensembl
ENSRNOG00055015191
resolver
ensembl
ENSRNOG00060017573
resolver
ensembl
ENSRNOG00065009008
resolver
ensp
ENSRNOP00000014909
resolver
ensp
ENSRNOP00055021182
resolver
ensp
ENSRNOP00060024247
resolver
ensp
ENSRNOP00065010792
resolver
enst
ENSRNOT00000014909
resolver
enst
ENSRNOT00055025992
resolver
enst
ENSRNOT00060030042
resolver
enst
ENSRNOT00065014401
resolver
genesymbol
Cpb2
resolver
uniprot
Q3B7V3
resolver
uniprot
Q5BKB8
resolver
uniprot_entry
CBPB2_RAT
resolver
uniprot_sec
Q3B7V3
resolver
uniprot_sec
Q5BKB8
resolver
activity_regulation
ACTIVITY REGULATION: TAFI/CPB2 is unique among carboxypeptidases in that it spontaneously inactivates with a short half-life, a property that is crucial for its role in controlling blood clot lysis. The zymogen is stabilized by interactions with the activation peptide. Release of the activation peptide increases a dynamic flap mobility and in time this leads to conformational changes that disrupt the catalytic site and expose a cryptic thrombin-cleavage site present at Arg-323 (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MKLYGLGVLVAIILYEKHGLAFQSGHVLSALPRTSRQVQLLQNLTTTYEVVLWQPVTAEFIEKKKEVHFFVNASDVNSVKAYLNASRIPFNVLMNNVEDLIQQQTSNDTVSPRASSSYYEQYHSLNEIYSWIEVITEQHPDMLQKIYIGSSYEKYPLYVLKVSGKEHRVKNAIWIDCGIHAREWISPAFCLWFIGYVTQFHGKENTYTRLLRHVDFYIMPVMNVDGYDYTWKKNRMWRKNRSVHMNNRCVGTDLNRNFASKHWCEKGASSFSCSETYCGLYPESEPEVKAVADFLRRNINHIKAYISMHSYSQQILFPYSYNRSKSKDHEELSLVASEAVRAIESINKNTRYTHGSGSESLYLAPGGSDDWIYDLGIKYSFTIELRDTGRYGFLLPERFIKPTCAEALAAVSKIAWHVIRNS
uniprot
proteins
ec_number
3.4.17.20
uniprot
proteins
function
FUNCTION: Cleaves C-terminal arginine or lysine residues from biologically active peptides such as kinins or anaphylatoxins in the circulation thereby regulating their activities. Down-regulates fibrinolysis by removing C-terminal lysine residues from fibrin that has already been partially degraded by plasmin. {ECO:0000269|PubMed:11021404}.
uniprot
proteins
mass_dalton
48827
uniprot
proteins
protein_family
Peptidase M14 family
uniprot
proteins
pubmed
11021404
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
422
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins