Nudt16l1
entrez
66911
canonical
uniprot
Q8VHN8
canonical
ensembl
ENSMUSG00000022516
resolver
ensp
ENSMUSP00000054201
resolver
ensp
ENSMUSP00000155142
resolver
genesymbol
Nudt16l1
resolver
genesymbol_syn
Sdos
resolver
genesymbol_syn
Tirr
resolver
uniprot
Q3TW47
resolver
uniprot
Q8R039
resolver
uniprot
Q8R3D9
resolver
uniprot
Q9CR90
resolver
uniprot
Q9D8M0
resolver
uniprot_entry
TIRR_MOUSE
resolver
uniprot_sec
Q3TW47
resolver
uniprot_sec
Q8R039
resolver
uniprot_sec
Q8R3D9
resolver
uniprot_sec
Q9CR90
resolver
uniprot_sec
Q9D8M0
resolver
amino_acid_sequence
MSTTTVPELKQISREEAMRLGPGWSHSCHAMLYAANPGQLFGRIPMRFSVLMQMRFDGLLGFPGGFVDRRFWSLEDGLNRVLGLGLGGLRLTEADYLSSHLTEGPHRVVAHLYARQLTLEQLHAVEISAVHSRDHGLEVLGLVRVPLYTQKDRVGGFPNFLSNAFVSTAKYQLLFALKVLNMMPSEKLAEALASATEKQKKALEKLLPPSS
uniprot
proteins
function
FUNCTION: Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin. In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus. Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs). Binds U8 snoRNA. {ECO:0000250|UniProtKB:Q9BRJ7}.
uniprot
proteins
mass_dalton
23414
uniprot
proteins
protein_family
Nudix hydrolase family
uniprot
proteins
protein_family
TIRR subfamily
uniprot
proteins
pubmed
11805099
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26100207
uniprot
proteins
sequence_length
211
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BRJ7}.
uniprot
proteins