KCNC4
entrez
3749
canonical
uniprot
Q03721
canonical
ensembl
ENSG00000116396
resolver
ensp
ENSP00000358802
resolver
ensp
ENSP00000388029
resolver
ensp
ENSP00000393655
resolver
ensp
ENSP00000668444
resolver
ensp
ENSP00000687758
resolver
ensp
ENSP00000779996
resolver
ensp
ENSP00000791585
resolver
ensp
ENSP00000791586
resolver
enst
ENST00000413138
resolver
genesymbol
KCNC4
resolver
genesymbol_syn
C1orf30
resolver
hgnc
HGNC:6236
resolver
uniprot
H7BZ66
resolver
uniprot
Q3MIM4
resolver
uniprot
Q5TBI6
resolver
uniprot_entry
H7BZ66_HUMAN
resolver
uniprot_entry
KCNC4_HUMAN
resolver
uniprot_sec
Q3MIM4
resolver
uniprot_sec
Q5TBI6
resolver
amino_acid_sequence
MISSVCVSSYRGRKSGNKPPSKTCLKEEMAKGEASEKIIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFDRHPGVFAYVLNYYRTGKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEEALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALFEDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVETEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLSGLSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKRKKHVPRPAQLESPMYCKSEETSPRDSTCSDTSPPAREEGMIERKRADSKQNGDANAVLSDEEGAGLTQPLASSPTPEERRALRRSTTRDRNKKAAACFLLSTGDYACADGSVRKGTFVLRDLPLQHSPEAACPPTAGTLFLPH
uniprot
proteins
function
FUNCTION: Voltage-gated potassium channel that opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient (PubMed:7993631). The channel displays rapid activation and inactivation kinetics (PubMed:7993631). {ECO:0000269|PubMed:7993631}.
uniprot
proteins
mass_dalton
69767
uniprot
proteins
mutagenesis
MUTAGEN 8; /note="S->A: Decreased inhibition of channel closure by PKC. Inhibition of channel closure is nearly abolished; when associated with A-9."; /evidence="ECO:0000269|PubMed:9649584"; MUTAGEN 8; /note="S->D: Decreased rate of channel inactivation. Loss of channel inactivation; when associated with D-9; D-15 and D-21."; /evidence="ECO:0000269|PubMed:9649584"; MUTAGEN 9; /note="S->A: Strong decrease of inhibition of channel closure by PKC. Inhibition of channel closure is nearly abolished; when associated with A-8."; /evidence="ECO:0000269|PubMed:9649584"; MUTAGEN 9; /note="S->D: Decreased rate of channel inactivation. Loss of channel inactivation; when associated with D-8; D-15 and D-21."; /evidence="ECO:0000269|PubMed:9649584"; MUTAGEN 15; /note="S->A: Decreased inhibition of channel closure by PKC."; /evidence="ECO:0000269|PubMed:7993631, ECO:0000269|PubMed:9649584"; MUTAGEN 15; /note="S->D: Slightly decreased rate of channel inactivation. Loss of channel inactivation; when associated with D-8; D-9 and D-21."; /evidence="ECO:0000269|PubMed:7993631, ECO:0000269|PubMed:9649584"; MUTAGEN 21; /note="S->A: Decreased inhibition of channel closure by PKC."; /evidence="ECO:0000269|PubMed:7993631, ECO:0000269|PubMed:9649584"; MUTAGEN 21; /note="S->D: Slightly decreased rate of channel inactivation. Loss of channel inactivation; when associated with D-8; D-9 and D-15."; /evidence="ECO:0000269|PubMed:7993631, ECO:0000269|PubMed:9649584
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of serine residues in the inactivation gate inhibits rapid channel closure. {ECO:0000269|PubMed:7993631, ECO:0000269|PubMed:9649584}.
uniprot
proteins
protein_family
C (Shaw) (TC 1.A.1.2) subfamily
uniprot
proteins
protein_family
Kv3.4/KCNC4 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
10048926
uniprot
proteins
pubmed
1381835
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
7993631
uniprot
proteins
pubmed
9000078
uniprot
proteins
pubmed
9649584
uniprot
proteins
sequence_length
635
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 227..247; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 278..298; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 313..333; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 345..364; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 381..401; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 452..472; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins