CEACAM3
entrez
1084
canonical
uniprot
P40198
canonical
ensembl
ENSG00000170956
resolver
ensp
ENSP00000341725
resolver
ensp
ENSP00000349971
resolver
genesymbol
CEACAM3
resolver
genesymbol_syn
CD66D
resolver
genesymbol_syn
CGM1
resolver
hgnc
HGNC:1815
resolver
uniprot
G5E978
resolver
uniprot
Q3KPH9
resolver
uniprot_entry
CEAM3_HUMAN
resolver
uniprot_sec
G5E978
resolver
uniprot_sec
Q3KPH9
resolver
amino_acid_sequence
MGPPSASPHRECIPWQGLLLTASLLNFWNPPTTAKLTIESMPLSVAEGKEVLLLVHNLPQHLFGYSWYKGERVDGNSLIVGYVIGTQQATPGAAYSGRETIYTNASLLIQNVTQNDIGFYTLQVIKSDLVNEEATGQFHVYQENAPGLPVGAVAGIVTGVLVGVALVAALVCFLLLAKTGRTSIQRDLKEQQPQALAPGRGPSHSSAFSMSPLSTAQAPLPNPRTAASIYEELLKHDTNIYCRMDHKAEVAS
uniprot
proteins
function
FUNCTION: Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis. {ECO:0000269|PubMed:12864848, ECO:0000269|PubMed:14707113}.
uniprot
proteins
mass_dalton
27091
uniprot
proteins
mutagenesis
MUTAGEN 230; /note="Y->F: Loss of phosphorylation and 30% reduction in bacterial uptake. More than 60% reduction in bacterial uptake and loss of RAC1 stimulation; when associated with F-241."; /evidence="ECO:0000269|PubMed:12864848, ECO:0000269|PubMed:14707113"; MUTAGEN 241; /note="Y->F: Loss of phosphorylation and 30% reduction in bacterial uptake. More than 60% reduction in bacterial uptake and loss of RAC1 stimulation; when associated with F-230."; /evidence="ECO:0000269|PubMed:12864848, ECO:0000269|PubMed:14707113
uniprot
proteins
post_translational_modification
PTM: Tyrosine-phosphorylated in response to microbial binding. Tyr-230 and Tyr-241 are both required for phosphorylation to be detected. {ECO:0000269|PubMed:12864848}.
uniprot
proteins
protein_family
CEA family
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
11708798
uniprot
proteins
pubmed
12864848
uniprot
proteins
pubmed
1427854
uniprot
proteins
pubmed
14707113
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2050678
uniprot
proteins
pubmed
8508798
uniprot
proteins
sequence_length
252
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 156..176; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins