TNFRSF25
entrez
8718
canonical
uniprot
Q93038
canonical
ensembl
ENSG00000215788
resolver
ensp
ENSP00000314451
resolver
ensp
ENSP00000326762
resolver
ensp
ENSP00000337713
resolver
ensp
ENSP00000349341
resolver
ensp
ENSP00000367013
resolver
genesymbol
TNFRSF25
resolver
genesymbol_syn
APO3
resolver
genesymbol_syn
DDR3
resolver
genesymbol_syn
DR3
resolver
genesymbol_syn
TNFRSF12
resolver
genesymbol_syn
WSL
resolver
genesymbol_syn
WSL1
resolver
hgnc
HGNC:11910
resolver
uniprot
B1ALX2
resolver
uniprot
B1ALX3
resolver
uniprot
B7ZLL7
resolver
uniprot
O00275
resolver
uniprot
O00276
resolver
uniprot
O00277
resolver
uniprot
O00278
resolver
uniprot
O00279
resolver
uniprot
O00280
resolver
uniprot
O14865
resolver
uniprot
O14866
resolver
uniprot
P78507
resolver
uniprot
P78515
resolver
uniprot
Q17RU4
resolver
uniprot
Q92983
resolver
uniprot
Q93036
resolver
uniprot
Q93037
resolver
uniprot
Q99722
resolver
uniprot
Q99830
resolver
uniprot
Q99831
resolver
uniprot
Q9BY86
resolver
uniprot
Q9UME0
resolver
uniprot
Q9UME1
resolver
uniprot
Q9UME5
resolver
uniprot_entry
TNR25_HUMAN
resolver
uniprot_sec
B1ALX2
resolver
uniprot_sec
B1ALX3
resolver
uniprot_sec
B7ZLL7
resolver
uniprot_sec
O00275
resolver
uniprot_sec
O00276
resolver
uniprot_sec
O00277
resolver
uniprot_sec
O00278
resolver
uniprot_sec
O00279
resolver
uniprot_sec
O00280
resolver
uniprot_sec
O14865
resolver
uniprot_sec
O14866
resolver
uniprot_sec
P78507
resolver
uniprot_sec
P78515
resolver
uniprot_sec
Q17RU4
resolver
uniprot_sec
Q92983
resolver
uniprot_sec
Q93036
resolver
uniprot_sec
Q93037
resolver
uniprot_sec
Q99722
resolver
uniprot_sec
Q99830
resolver
uniprot_sec
Q99831
resolver
uniprot_sec
Q9BY86
resolver
uniprot_sec
Q9UME0
resolver
uniprot_sec
Q9UME1
resolver
uniprot_sec
Q9UME5
resolver
amino_acid_sequence
MEQRPRGCAAVAAALLLVLLGARAQGGTRSPRCDCAGDFHKKIGLFCCRGCPAGHYLKAPCTEPCGNSTCLVCPQDTFLAWENHHNSECARCQACDEQASQVALENCSAVADTRCGCKPGWFVECQVSQCVSSSPFYCQPCLDCGALHRHTRLLCSRRDTDCGTCLPGFYEHGDGCVSCPTSTLGSCPERCAAVCGWRQMFWVQVLLAGLVVPLLLGATLTYTYRHCWPHKPLVTADEAGMEALTPPPATHLSPLDSAHTLLAPPDSSEKICTVQLVGNSWTPGYPETQEALCPQVTWSWDQLPSRALGPAAAPTLSPESPAGSPAMMLQPGPQLYDVMDAVPARRWKEFVRTLGLREAEIEAVEVEIGRFRDQQYEMLKRWRQQQPAGLGAVYAALERMGLDGCVEDLRSRLQRGP
uniprot
proteins
function
FUNCTION: Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis. {ECO:0000269|PubMed:8875942, ECO:0000269|PubMed:8994832, ECO:0000269|PubMed:9052839}.
uniprot
proteins
mass_dalton
45385
uniprot
proteins
mutagenesis
MUTAGEN 354; /note="L->A: Suppresses homodimerization, TNFR1 interaction, and apoptosis induction."; /evidence="ECO:0000269|PubMed:8934525"; MUTAGEN 356; /note="L->A: Suppresses homodimerization, and TNFR1 interaction."; /evidence="ECO:0000269|PubMed:8934525"; MUTAGEN 373; /note="D->A: Suppresses homodimerization, and TNFR1 interaction."; /evidence="ECO:0000269|PubMed:8934525
uniprot
proteins
post_translational_modification
PTM: (Microbial infection) Glycosylated at Arg-352 by enteropathogenic E.coli protein NleB1. {ECO:0000305|PubMed:30979585}.; PTM: Glycosylated. {ECO:0000305}.
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14759258
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
30979585
uniprot
proteins
pubmed
8875942
uniprot
proteins
pubmed
8934525
uniprot
proteins
pubmed
8994832
uniprot
proteins
pubmed
9052839
uniprot
proteins
pubmed
9114039
uniprot
proteins
pubmed
9446802
uniprot
proteins
pubmed
9915703
uniprot
proteins
sequence_length
417
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 9]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 11]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted.; SUBCELLULAR LOCATION: [Isoform 4]: Secreted.; SUBCELLULAR LOCATION: [Isoform 5]: Secreted.; SUBCELLULAR LOCATION: [Isoform 6]: Secreted.; SUBCELLULAR LOCATION: [Isoform 7]: Secreted.; SUBCELLULAR LOCATION: [Isoform 8]: Secreted.; SUBCELLULAR LOCATION: [Isoform 10]: Secreted.; SUBCELLULAR LOCATION: [Isoform 12]: Secreted.
uniprot
proteins
transmembrane_region
TRANSMEM 200..220; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins