Clcn4
entrez
12727
canonical
uniprot
Q61418
canonical
ensembl
ENSMUSG00000000605
resolver
ensp
ENSMUSP00000000619
resolver
ensp
ENSMUSP00000147562
resolver
ensp
ENSMUSP00000148174
resolver
ensp
ENSMUSP00000169887
resolver
ensp
ENSMUSP00000169888
resolver
ensp
ENSMUSP00000169890
resolver
ensp
ENSMUSP00000169894
resolver
ensp
ENSMUSP00000169896
resolver
enst
ENSMUST00000000619
resolver
enst
ENSMUST00000210061
resolver
enst
ENSMUST00000210594
resolver
genesymbol
Clcn4
resolver
genesymbol_syn
Clc4
resolver
genesymbol_syn
Clcn4-2
resolver
uniprot
A0A1B0GRK7
resolver
uniprot
A0A1B0GT29
resolver
uniprot
Q2TAX6
resolver
uniprot
Q3LRV6
resolver
uniprot
Q8BQG0
resolver
uniprot
Q8CBL5
resolver
uniprot_entry
A0A1B0GRK7_MOUSE
resolver
uniprot_entry
A0A1B0GT29_MOUSE
resolver
uniprot_entry
CLCN4_MOUSE
resolver
uniprot_entry
Q3LRV6_MOUSE
resolver
uniprot_entry
Q8BQG0_MOUSE
resolver
uniprot_entry
Q8CBL5_MOUSE
resolver
uniprot_sec
Q2TAX6
resolver
amino_acid_sequence
MDFLEEPFPDVGTYEDFHTIDWLREKSRDTDRHRKITSKSKESIWEFIKSLLDAWSGWVVMLLIGLLAGTLAGVIDLAVDWMTDLKEGVCLSAFWYSHEQCCWTSNETTFEDRDKCPLWQKWSELLLSQSEGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLLIKTVTLVLVVSSGLSLGKEGPLVHVACCCGNFFSSLFSKYSKNEGKRREVLSAAAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRLVLFYVEYHTPWYMAELFPFILLGVFGGLWGTLFTRCNIAWCRRRKTTRLGRYPVLEVIAVTAVTAIVAYPNPYTRQSTSELISELFNDCGALESSQLCDYINDPNMTRPVDDIPDRPAGVGVYTAMWQLALALIFKIVITIFTFGMKIPSGLFIPSMAVGAMAGRMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVTRMTVSLVVIMFELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVKDEFTHRTLATDVMRPRRGEPPLSVLTQDSMTVEDVETLIKETDYNGFPVLVSRDSERLIGFAQRRELILAIKNARQRQEGIVSNSIMYFTEEPPELPANSPHPLKLRRILNLSPFTVTDHTPMETVVDIFRKLGLRQCLVTRSGRLLGIITKKDVLRHMAQMANQDPESIMFN
uniprot
proteins
function
FUNCTION: Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). {ECO:0000250|UniProtKB:P51793}.
uniprot
proteins
mass_dalton
83733
uniprot
proteins
protein_family
Chloride channel (TC 2.A.49) family
uniprot
proteins
protein_family
ClC-4/CLCN4 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17023393
uniprot
proteins
pubmed
7670496
uniprot
proteins
sequence_length
747
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000250|UniProtKB:P51794}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000250|UniProtKB:P51794}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P51793}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:P51793}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000250|UniProtKB:P51793}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to late endosome membrane, lysosome membrane and recycling endosome membrane in the presence of CLCN3. {ECO:0000250|UniProtKB:P51793}.
uniprot
proteins
transmembrane_region
TRANSMEM 55..92; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 138..161; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 187..205; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 211..230; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 278..296; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 320..345; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 352..372; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 429..449; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 454..473; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523"; TRANSMEM 535..553; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P35523
uniprot
proteins