Rsad2
entrez
58185
canonical
uniprot
Q8CBB9
canonical
ensembl
ENSMUSG00000020641
resolver
ensp
ENSMUSP00000020970
resolver
enst
ENSMUST00000020970
resolver
genesymbol
Rsad2
resolver
genesymbol_syn
Vig1
resolver
uniprot
Q3U5I6
resolver
uniprot
Q3U5T4
resolver
uniprot
Q3U622
resolver
uniprot
Q3U627
resolver
uniprot
Q3U7I6
resolver
uniprot
Q3U7M1
resolver
uniprot
Q3U8F4
resolver
uniprot
Q3U8U7
resolver
uniprot
Q3U941
resolver
uniprot
Q3U977
resolver
uniprot
Q3U9E1
resolver
uniprot
Q3U9J0
resolver
uniprot
Q3U9J3
resolver
uniprot
Q3UBW6
resolver
uniprot
Q3UC07
resolver
uniprot
Q3UDI0
resolver
uniprot
Q6PEU4
resolver
uniprot
Q8VHM2
resolver
uniprot
Q9JHD4
resolver
uniprot_entry
RSAD2_MOUSE
resolver
uniprot_sec
Q3U5I6
resolver
uniprot_sec
Q3U5T4
resolver
uniprot_sec
Q3U622
resolver
uniprot_sec
Q3U627
resolver
uniprot_sec
Q3U7I6
resolver
uniprot_sec
Q3U7M1
resolver
uniprot_sec
Q3U8F4
resolver
uniprot_sec
Q3U8U7
resolver
uniprot_sec
Q3U941
resolver
uniprot_sec
Q3U977
resolver
uniprot_sec
Q3U9E1
resolver
uniprot_sec
Q3U9J0
resolver
uniprot_sec
Q3U9J3
resolver
uniprot_sec
Q3UBW6
resolver
uniprot_sec
Q3UC07
resolver
uniprot_sec
Q3UDI0
resolver
uniprot_sec
Q6PEU4
resolver
uniprot_sec
Q8VHM2
resolver
uniprot_sec
Q9JHD4
resolver
activity_regulation
ACTIVITY REGULATION: IRAK1 and TRAF6 synergistically activate RSAD2 increasing its activity with CTP as substrate about 10-fold. {ECO:0000250|UniProtKB:Q8WXG1}.
uniprot
proteins
amino_acid_sequence
MGMLVPTALAARLLSLFQQQLGSLWSGLAILFCWLRIALGWLDPGKEQPQVRGEPEDTQETQEDGNSTQPTTPVSVNYHFTRQCNYKCGFCFHTAKTSFVLPLEEAKRGLLLLKQAGLEKINFSGGEPFLQDRGEYLGKLVRFCKEELALPSVSIVSNGSLIRERWFKDYGEYLDILAISCDSFDEQVNALIGRGQGKKNHVENLQKLRRWCRDYKVAFKINSVINRFNVDEDMNEHIKALSPVRWKVFQCLLIEGENSGEDALREAERFLISNEEFETFLERHKEVSCLVPESNQKMKDSYLILDEYMRFLNCTGGRKDPSKSILDVGVEEAIKFSGFDEKMFLKRGGKYVWSKADLKLDW
uniprot
proteins
ec_number
4.2.-.-
uniprot
proteins
function
FUNCTION: Interferon-inducible antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Catalyzes the conversion of cytidine triphosphate (CTP) to 3'-deoxy-3',4'-didehydro-CTP (ddhCTP) via a SAM-dependent radical mechanism. In turn, ddhCTP acts as a chain terminator for the RNA-dependent RNA polymerases from multiple viruses and directly inhibits viral replication. Therefore, inhibits a wide range of DNA and RNA viruses (By similarity). Also promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating 'Lys-63'-linked ubiquitination of IRAK1 by TRAF6. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins (By similarity) (PubMed:17686841, PubMed:19047684, PubMed:21435586, PubMed:21880757). {ECO:0000250|UniProtKB:Q8WXG1, ECO:0000269|PubMed:17686841, ECO:0000269|PubMed:19047684, ECO:0000269|PubMed:21435586, ECO:0000269|PubMed:21880757}.
uniprot
proteins
mass_dalton
41524
uniprot
proteins
post_translational_modification
PTM: Acetylated by HAT1. HAT1-mediated acetylation of Lys-198 in turn recruits UBE4A that stimulates RSAD2 polyubiquitination leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q8WXG1}.; PTM: 'Lys-6'-linked polyubiquitination at Lys-207 leads to RSAD2 protein degradation. {ECO:0000250|UniProtKB:Q8WXG1}.
uniprot
proteins
protein_family
RSAD2 family
uniprot
proteins
protein_family
Radical SAM superfamily
uniprot
proteins
pubmed
11038379
uniprot
proteins
pubmed
11752458
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15890971
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16849320
uniprot
proteins
pubmed
17686841
uniprot
proteins
pubmed
19047684
uniprot
proteins
pubmed
19920176
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21435586
uniprot
proteins
pubmed
21880757
uniprot
proteins
pubmed
22177558
uniprot
proteins
pubmed
28607080
uniprot
proteins
pubmed
36387278
uniprot
proteins
sequence_length
362
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8WXG1}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8WXG1}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8WXG1}. Golgi apparatus {ECO:0000250|UniProtKB:Q8WXG1}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8WXG1}. Lipid droplet {ECO:0000269|PubMed:19920176, ECO:0000269|PubMed:21435586}. Mitochondrion {ECO:0000250|UniProtKB:Q8WXG1}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q8WXG1}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q8WXG1}.
uniprot
proteins