Erbb3
entrez
13867
canonical
uniprot
Q61526
canonical
ensembl
ENSMUSG00000018166
resolver
ensp
ENSMUSP00000080716
resolver
enst
ENSMUST00000082059
resolver
genesymbol
Erbb3
resolver
uniprot
Q3KQR1
resolver
uniprot
Q68J64
resolver
uniprot
Q810U8
resolver
uniprot
Q8K317
resolver
uniprot_entry
ERBB3_MOUSE
resolver
uniprot_sec
Q3KQR1
resolver
uniprot_sec
Q68J64
resolver
uniprot_sec
Q810U8
resolver
uniprot_sec
Q8K317
resolver
amino_acid_sequence
MSAIGTLQVLGFLLSLARGSEMGNSQAVCPGTLNGLSVTGDADNQYQTLYKLYEKCEVVMGNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSVLPLPNLRVVRGTQVYDGKFAIFVMLNYNTNSSHALRQLRFTQLTEILLGGVYIEKNDKLCHMDTIDWRDIVRVPDAEIVVKNNGGNCPPCHEVCKGRCWGPGPEDCQILTKTICAPQCNGRCFGPNPNQCCHDECAGGCSGPQDTDCFACRHFNDSGACVPRCPAPLVYNKLTFQLEPNPHIKYQYGGVCVASCPHNFVVDQTFCVRACPADKMEVDKNGLKMCEPCRGLCPKACEGTGSGSRYQTVDSSNIDGFVNCTKILGNLDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGGRSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRVYISANQQLCYHHSLNWTRLLRGPAEERLDIKYNRPLGECVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSREGVCVTHCNVLQGEPREFVHEAHCFSCHPECQPMEGTSTCNGSGSDACARCAHFRDGPHCVNSCPHGILGAKGPIYKYPDAQNECRPCHENCTQGCKGPELQDCLGQAEVLMSKPHLVIAVTVGLTVIFLILGGSFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVFGTVHKGIWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAVGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLDHVRQHRETLGPQLLLNWGVQIAKGMYYLEEHSMVHRDLALRNVMLKSPSQVQVADFGVADLLPPDDKQLLHSEAKTPIKWMALESIHFGKYTHQSDVWSYGVTVWELMTFGAEPYAGLRLAEIPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKELANEFTRMARDPPRYLVIKRASGPGIPPAAEPSALSTKELQDAELEPDLDLDLDVEVEEEGLATTLGSALSLPTGTLTRPRGSQSLLSPSSGYMPMNQSNLGEACLDSAVLGGREQFSRPISLHPIPRGRQTSESSEGHVTGSEAELQERVSMCRSRSRSRSPRPRGDSAYHSQRHSLLTPVTPLSPPGLEEEDGNGYVMPDTHLRGTSSSREGTLSSVGLSSVLGTEEEDEDEEYEYMNRKRRGSPARPPRPGSLEELGYEYMDVGSDLSASLGSTQSCPLHPMAIVPSAGTTPDEDYEYMNRRRGAGGSGGDYAAMGACPAAEQGYEEMRAFQGPGHQAPHVRYARLKTLRSLEATDSAFDNPDYWHSRLFPKANAQRI
uniprot
proteins
ec_number
2.7.10.1
uniprot
proteins
function
FUNCTION: Tyrosine kinase receptor that, despite substitutions of key catalytic residues in the kinase domain, retains residual catalytic activity enabling autophosphorylation. Functions primarily as a heterodimer, preferentially partnering with ERBB2/HER2, which phosphorylates ERBB3 on specific tyrosine residues and provides the kinase activity required for downstream signaling. Binds neuregulins NRG1 and NRG2 through its extracellular domain, which induces conformational change from a tethered autoinhibited state to an extended conformation competent for dimerization. Upon heterodimerization and trans-phosphorylation, acts as the most efficient activator of the PI3K/AKT pathway within the ErbB family. Also activates the RAS/MAPK/ERK cascade to promote cell proliferation (By similarity). Plays an essential role in cardiac development; required for normal formation of the endocardial cushion and ventricular trabeculation during embryogenesis (PubMed:9362461). Critical for peripheral nervous system development, where neuregulin-1/ERBB3 signaling drives Schwann cell survival, proliferation, and differentiation, and is required for axonal myelination (PubMed:9338783). Involved in epithelial morphogenesis and mammary gland development (PubMed:19019207). Also involved in the regulation of myeloid cell differentiation. Participates in a regulatory feedback loop whereby pathway activation induces transcriptional up-regulation of ERBB3 expression. Participates in vesicular sorting by stabilizing the ARF6-GGA3-RABEP1 endosomal sorting complex, to promote early recycling of TFRC and ITGB1. May also be activated by additional ligands including CSPG5 and EGFL6; the latter triggers assembly of an ERBB2/ERBB3/ITGB3 signaling complex leading to ERK phosphorylation and cell proliferation (By similarity). {ECO:0000250|UniProtKB:P21860, ECO:0000269|PubMed:19019207, ECO:0000269|PubMed:9338783, ECO:0000269|PubMed:9362461}.
uniprot
proteins
mass_dalton
147613
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase. {ECO:0000250|UniProtKB:P21860}.
uniprot
proteins
protein_family
EGF receptor subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19019207
uniprot
proteins
pubmed
23897819
uniprot
proteins
pubmed
7589796
uniprot
proteins
pubmed
9338783
uniprot
proteins
pubmed
9362461
uniprot
proteins
sequence_length
1339
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 642..662; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins