Tprn
entrez
499749
canonical
uniprot
Q5XHX2
canonical
ensembl
ENSRNOG00000010896
resolver
ensembl
ENSRNOG00055000500
resolver
ensembl
ENSRNOG00060031030
resolver
ensembl
ENSRNOG00065025058
resolver
ensp
ENSRNOP00000014489
resolver
ensp
ENSRNOP00055000678
resolver
ensp
ENSRNOP00060044699
resolver
ensp
ENSRNOP00065035288
resolver
enst
ENSRNOT00055000864
resolver
enst
ENSRNOT00060053891
resolver
enst
ENSRNOT00065043090
resolver
genesymbol
Tprn
resolver
uniprot_entry
TPRN_RAT
resolver
amino_acid_sequence
MAGLGRLDPGPRTVMPAWKREILERRRAKLAALSGGPGSGAAPDGPNERLVLAESLGPLSQNPFMRLESERRRGARPAQQLLELYCRVPGVRTIRADNILIIESAPGFPPAVPPASSIRAAEVVVYEEPQPGRVSRLLEKFDSPAAPRRRGSPERFRPALPQLPVAPASAATRAPTNRSLAPAPPVLPSQPAPPISPVPVAQRAGQRSACCEPAHPDGTAGPGARRSDFLQKTGSNSFTVHPRGLPGSAVNRSLSNGPMTQESPAGPANGLSGSPPVPGKWKPKVESKEPSLHPPPSPGTPSATPVGPPAFLAPSPASATPSQRQWVSSATSANDSFEIRPSSKPDMETIPIGDLQARALANLRVNSRNSFVLIPKRKAPGNYPSAAGRQFEEPKGEVGWASQSQGLGSQLVSTVDGAPALEKSSLAAEMQWAVREGGCPRPAISDTDKSVRRQRPASPPPFLPATTEAEPAEGLGVPGLTKNGQEPVRPGLPVTFIDEVDSEEAAFQEAKLPSSAVGVPSQYHLHPSTPGHTSELLNRGSNTFTVVPKRKPGTLQEPHLSQTNGQFQQGAEEQDADSLSGPHTTLENALKKRYPTVNEIEVIGGYLALQKSCLIKAGSSRKKMKISFNDKSLHTTFEYPSESSLAQEEAEEEEEEEEEEEGEDGEEEEVGPDSEKSFTVLLPRATFVSSVGPESSSGLSSYTPKHSMAFSKWQEQTLVQAPTEVELPPKEVMLTPASQNDLSDFRSEPALYF
uniprot
proteins
function
FUNCTION: Essential for hearing (By similarity). Required for maintenance of stereocilia on both inner and outer hair cells (By similarity). Necessary for the integrity of the stereociliary rootlet (By similarity). May act as an actin cytoskeleton regulator involved in the regulation of actin dynamics at the pointed end in hair cells (By similarity). Forms rings at the base of stereocilia and binds actin filaments in the stereocilia which may stabilize the stereocilia (By similarity). Acts as a strong inhibitor of PPP1CA phosphatase activity (By similarity). Recruited to sites of DNA damage and may play a role in DNA damage repair (By similarity). {ECO:0000250|UniProtKB:A2AI08, ECO:0000250|UniProtKB:Q4KMQ1}.
uniprot
proteins
mass_dalton
80272
uniprot
proteins
protein_family
Taperin family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
753
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, stereocilium {ECO:0000250|UniProtKB:A2AI08}. Cell projection, microvillus {ECO:0000250|UniProtKB:A2AI08}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q4KMQ1}. Cytoplasm {ECO:0000250|UniProtKB:Q4KMQ1}. Note=Localized prominently at the basal taper region of hair cell stereocilia (By similarity). Forms organized ring-like structures with diameters ranging from 150 to 200 nm in the stereocilium taper region (By similarity). Detected in microvilli of inner hair cell supporting cells (By similarity). Predominantly nuclear in non-stereocilium cells but can shuttle between the nucleus and the cytoplasm (By similarity). {ECO:0000250|UniProtKB:A2AI08, ECO:0000250|UniProtKB:Q4KMQ1}.
uniprot
proteins