Hcar2
entrez
80885
canonical
uniprot
Q9EP66
canonical
ensembl
ENSMUSG00000045502
resolver
ensp
ENSMUSP00000054104
resolver
enst
ENSMUST00000057145
resolver
genesymbol
Hcar2
resolver
genesymbol_syn
Gpr109
resolver
genesymbol_syn
Gpr109a
resolver
genesymbol_syn
Gpr109b
resolver
genesymbol_syn
Niacr1
resolver
genesymbol_syn
Pumag
resolver
uniprot
Q0VBA6
resolver
uniprot_entry
HCAR2_MOUSE
resolver
uniprot_entry
Q0VBA6_MOUSE
resolver
amino_acid_sequence
MSKSDHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLTDNYVHNWDWRFGGIPCRVMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHFLNKISNRTAAIISCFLWGLTIGLTVHLLYTNMMTKNGEAYLCSSFSICYNFRWHDAMFLLEFFLPLAIILFCSGRIIWSLRQRQMDRHAKIKRAINFIMVVAIVFIICFLPSVAVRIRIFWLLYKYNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPNFFSTCINRCLRKKTLGEPDNNRSTSVELTGDPSTTRSIPGALMADPSEPGSPPYLASTSR
uniprot
proteins
function
FUNCTION: Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. {ECO:0000269|PubMed:15929991}.
uniprot
proteins
mass_dalton
41401
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11745392
uniprot
proteins
pubmed
12646212
uniprot
proteins
pubmed
15929991
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19141678
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
360
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 31..51; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 61..81; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 99..119; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 141..161; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 190..210; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 227..247; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 271..291; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins