TRIM29
entrez
23650
canonical
uniprot
Q14134
canonical
ensembl
ENSG00000137699
resolver
ensp
ENSP00000343129
resolver
ensp
ENSP00000436015
resolver
ensp
ENSP00000524306
resolver
enst
ENST00000529044
resolver
genesymbol
TRIM29
resolver
genesymbol_syn
ATDC
resolver
hgnc
HGNC:17274
resolver
uniprot
B7Z5V5
resolver
uniprot
B7Z8U9
resolver
uniprot
E9PRL4
resolver
uniprot
Q96AA9
resolver
uniprot
Q9BZY7
resolver
uniprot_entry
B7Z5V5_HUMAN
resolver
uniprot_entry
B7Z8U9_HUMAN
resolver
uniprot_entry
E9PRL4_HUMAN
resolver
uniprot_entry
TRI29_HUMAN
resolver
uniprot_sec
Q96AA9
resolver
uniprot_sec
Q9BZY7
resolver
amino_acid_sequence
MEAADASRSNGSSPEARDARSPSGPSGSLENGTKADGKDAKTTNGHGGEAAEGKSLGSALKPGEGRSALFAGNEWRRPIIQFVESGDDKNSNYFSMDSMEGKRSPYAGLQLGAAKKPPVTFAEKGELRKSIFSESRKPTVSIMEPGETRRNSYPRADTGLFSRSKSGSEEVLCDSCIGNKQKAVKSCLVCQASFCELHLKPHLEGAAFRDHQLLEPIRDFEARKCPVHGKTMELFCQTDQTCICYLCMFQEHKNHSTVTVEEAKAEKETELSLQKEQLQLKIIEIEDEAEKWQKEKDRIKSFTTNEKAILEQNFRDLVRDLEKQKEEVRAALEQREQDAVDQVKVIMDALDERAKVLHEDKQTREQLHSISDSVLFLQEFGALMSNYSLPPPLPTYHVLLEGEGLGQSLGNFKDDLLNVCMRHVEKMCKADLSRNFIERNHMENGGDHRYVNNYTNSFGGEWSAPDTMKRYSMYLTPKGGVRTSYQPSSPGRFTKETTQKNFNNLYGTKGNYTSRVWEYSSSIQNSDNDLPVVQGSSSFSLKGYPSLMRSQSPKAQPQTWKSGKQTMLSHYRPFYVNKGNGIGSNEAP
uniprot
proteins
function
FUNCTION: Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation. {ECO:0000269|PubMed:27695001, ECO:0000269|PubMed:29038422}.
uniprot
proteins
mass_dalton
65835
uniprot
proteins
post_translational_modification
PTM: Constitutively phosphorylated by PKC on serine/threonine in A431 cells. {ECO:0000269|PubMed:8647648}.
uniprot
proteins
pubmed
11331580
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
27695001
uniprot
proteins
pubmed
29038422
uniprot
proteins
pubmed
7644499
uniprot
proteins
pubmed
8188213
uniprot
proteins
pubmed
8647648
uniprot
proteins
sequence_length
588
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:7644499}. Lysosome {ECO:0000269|PubMed:27695001}. Note=Colocalizes with intermediate filaments.
uniprot
proteins