Bmp8a
entrez
12163
canonical
uniprot
P34821
canonical
ensembl
ENSMUSG00000032726
resolver
ensp
ENSMUSP00000037779
resolver
ensp
ENSMUSP00000099701
resolver
genesymbol
Bmp8a
resolver
genesymbol_syn
Bmp-8
resolver
genesymbol_syn
Bmp8
resolver
uniprot
Q3TZB2
resolver
uniprot
Q80VZ0
resolver
uniprot_entry
BMP8A_MOUSE
resolver
uniprot_entry
Q3TZB2_MOUSE
resolver
uniprot_entry
Q80VZ0_MOUSE
resolver
amino_acid_sequence
MAMRPGPLWLLGLALCALGGGHGPRPPHTCPQRRLGARERRDMQREILAVLGLPGRPRPRAQPAAARQPASAPLFMLDLYHAMTDDDDGGPPQAHLGRADLVMSFVNMVERDRTLGYQEPHWKEFHFDLTQIPAGEAVTAAEFRIYKEPSTHPLNTTLHISMFEVVQEHSNRESDLFFLDLQTLRSGDEGWLVLDITAASDRWLLNHHKDLGLRLYVETADGHSMDPGLAGLLGRQAPRSRQPFMVTFFRASQSPVRAPRAARPLKRRQPKKTNELPHPNKLPGIFDDGHGSRGREVCRRHELYVSFRDLGWLDWVIAPQGYSAYYCEGECAFPLDSCMNATNHAILQSLVHLMKPDVVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGCH
uniprot
proteins
function
FUNCTION: Growth factor of the TGF-beta superfamily that plays important role in various biological processes, including spermatogenesis, osteogenesis, steroidogenesis as well as regulation of energy balance (PubMed:12925636, PubMed:28465413, PubMed:9463357). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A (By similarity). In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. In addition, activates the SMAD2/3 pathway (PubMed:28465413). {ECO:0000250|UniProtKB:Q7Z5Y6, ECO:0000269|PubMed:12925636, ECO:0000269|PubMed:28465413, ECO:0000269|PubMed:9463357}.
uniprot
proteins
mass_dalton
44764
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
12925636
uniprot
proteins
pubmed
1460021
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21277400
uniprot
proteins
pubmed
28465413
uniprot
proteins
pubmed
8843393
uniprot
proteins
pubmed
9463357
uniprot
proteins
sequence_length
399
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
uniprot
proteins