Cbx7
entrez
52609
canonical
uniprot
Q8VDS3
canonical
ensembl
ENSMUSG00000053411
resolver
ensp
ENSMUSP00000086708
resolver
ensp
ENSMUSP00000105244
resolver
ensp
ENSMUSP00000105245
resolver
ensp
ENSMUSP00000290933
resolver
enst
ENSMUST00000089293
resolver
enst
ENSMUST00000109615
resolver
enst
ENSMUST00000109616
resolver
genesymbol
Cbx7
resolver
genesymbol_syn
D15Ertd417e
resolver
uniprot
F8WHN2
resolver
uniprot_entry
CBX7_MOUSE
resolver
uniprot_entry
F8WHN2_MOUSE
resolver
amino_acid_sequence
MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEERDRASGYRKRGPKPRRLLLQESAAPDVVQTPGDWEPMEQAPEEEAEADLTNGPPPWTPTLPSSEVTVTDITANSVTVTFREAQAAEGFFRDRNEKL
uniprot
proteins
function
FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:16537902, PubMed:22226355). PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3) (By similarity). Binds to histone H3 trimethylated at 'Lys-9' (H3K9me3) or at 'Lys-27' (H3K27me3) (PubMed:16537902, PubMed:22226355). Trimethylation at 'Lys-27' (H3K27me3) is important for chromatin recruitment (PubMed:16537902, PubMed:22226355). May possibly also bind trimethylated lysine residues in other proteins (in vitro) (PubMed:16537902). Binds non-coding, single-stranded RNA and double-stranded RNA (PubMed:16537902, PubMed:20541999). Plays a role in the timely repression of differentiation-specific genes in pluripotent embryonic stem cells to maintain the undifferentiated state (PubMed:22226355). Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity (PubMed:14647293). {ECO:0000250|UniProtKB:O95931, ECO:0000269|PubMed:14647293, ECO:0000269|PubMed:16537902, ECO:0000269|PubMed:20541999, ECO:0000269|PubMed:22226355}.
uniprot
proteins
mass_dalton
18109
uniprot
proteins
mutagenesis
MUTAGEN 11; /note="F->A: Abolishes binding to trimethylated histone H3."; /evidence="ECO:0000269|PubMed:16537902"; MUTAGEN 17; /note="R->A,Q: Strongly reduced RNA binding. Prevents cellular senescence and promotes continued cell division."; /evidence="ECO:0000269|PubMed:20541999"; MUTAGEN 31; /note="K->A: Strongly reduced RNA binding."; /evidence="ECO:0000269|PubMed:20541999"; MUTAGEN 35; /note="W->A: Strongly reduced binding to methylated histone H3 (H3K27me3). Causes premature cellular senescence."; /evidence="ECO:0000269|PubMed:16537902, ECO:0000269|PubMed:20541999
uniprot
proteins
pubmed
14647293
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16537902
uniprot
proteins
pubmed
20541999
uniprot
proteins
pubmed
22226355
uniprot
proteins
sequence_length
158
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14647293, ECO:0000269|PubMed:16537902, ECO:0000269|PubMed:20541999}. Chromosome {ECO:0000269|PubMed:16537902, ECO:0000269|PubMed:22226355}. Note=Requires trimethylation at 'Lys-27' (H3K27me3) for the localization to chromatin (PubMed:22226355). Localizes to facultative heterochromatin and to the inactivated X chromosome in females (PubMed:16537902). {ECO:0000269|PubMed:16537902, ECO:0000269|PubMed:22226355}.
uniprot
proteins