RASGRF1
entrez
5923
canonical
uniprot
Q13972
canonical
ensembl
ENSG00000058335
resolver
ensp
ENSP00000378228
resolver
ensp
ENSP00000405963
resolver
ensp
ENSP00000452781
resolver
genesymbol
RASGRF1
resolver
genesymbol_syn
CDC25
resolver
genesymbol_syn
GNRP
resolver
genesymbol_syn
GRF1
resolver
hgnc
HGNC:9875
resolver
uniprot
A8K270
resolver
uniprot
F8VPA5
resolver
uniprot
H0YKF2
resolver
uniprot
J3KQP9
resolver
uniprot
Q16027
resolver
uniprot
Q8IUU5
resolver
uniprot_entry
A8K270_HUMAN
resolver
uniprot_entry
Q8IUU5_HUMAN
resolver
uniprot_entry
RGRF1_HUMAN
resolver
uniprot_sec
F8VPA5
resolver
uniprot_sec
H0YKF2
resolver
uniprot_sec
J3KQP9
resolver
uniprot_sec
Q16027
resolver
amino_acid_sequence
MQKGIRLNDGHVASLGLLARKDGTRKGYLSKRSSDNTKWQTKWFALLQNLLFYFESDSSSRPSGLYLLEGCVCDRAPSPKPALSAKEPLEKQHYFTVNFSHENQKALELRTEDAKDCDEWVAAIAHASYRTLATEHEALMQKYLHLLQIVETEKTVAKQLRQQIEDGEIEIERLKAEITSLLKDNERIQSTQTVAPNDEDSDIKKIKKVQSFLRGWLCRRKWKTIIQDYIRSPHADSMRKRNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSETIMFLHQIFYQGLKARISSWPTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQNRDFDKLLKHYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAKSKLEELSRIMHDEVSETENIRKNLAIERMIIEGCEILLDTSQTFVRQGSLIQVPMSEKGKITRGRLGSLSLKKEGERQCFLFSKHLIICTRGSGGKLHLTKNGVISLIDCTLLEEPESTEEEAKGSGQDIDHLDFKIGVEPKDSPPFTVILVASSRQEKAAWTSDISQCVDNIRCNGLMMNAFEENSKVTVPQMIKRTREGTREAEMSRSDASLYCDDVDIRFSKTMNSCKVLQIRYASVERLLERLTDLRFLSIDFLNTFLHSYRVFTTAIVVLDKLITIYKKPISAIPARWLRSLELLFASGQNNKLLYGEPPKSPRATRKFSSPPPLSITKTSSPSRRRKLSLNIPIITGGKALDLAALSCNSNGYTSMYSAMSPFSKATLDTSKLYVSSSFTNKIPDEGDTTPEKPEDPSALSKQSSEVSMREESDIDQNQSDDGDTETSPTKSPTTPKSVKNKNSSEFPLFSYNNGVVMTSCRELDNNRSALSAASAFAIATAGANEGTPNKEKYRRMSLASAGFPPDQRNGDKEFVIRRAATNRVLNVLRHWVSKHSQDFETNDELKCKVIGFLEEVMHDPELLTQERKAAANIIRTLTQEDPGDNQITLEEITQMAEGVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEKNERTPYIMKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRSAIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNCDPPCVPYLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYLLDQSFVMDEESLYESSLRIEPKLPT
uniprot
proteins
function
FUNCTION: Promotes the exchange of Ras-bound GDP by GTP. {ECO:0000269|PubMed:11389730}.
uniprot
proteins
mass_dalton
145234
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PLK2, leading to ubiquitination and degradation by the proteasome. {ECO:0000250}.; PTM: Ubiquitinated and degraded following phosphorylation by PLK2. {ECO:0000250}.; PTM: Phosphorylated by SRC and LCK. Phosphorylation by LCK increases its capacity to stimulate the GDP/GTP exchange on Ras, whereas its phosphorylation by SRC does not seem to have an effect on stimulation activity. {ECO:0000269|PubMed:11389730}.
uniprot
proteins
pubmed
10373510
uniprot
proteins
pubmed
11389730
uniprot
proteins
pubmed
1379731
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
7684828
uniprot
proteins
pubmed
7828890
uniprot
proteins
sequence_length
1273
uniprot
proteins