Slc25a38
entrez
208638
canonical
uniprot
Q91XD8
canonical
ensembl
ENSMUSG00000032519
resolver
ensp
ENSMUSP00000035106
resolver
ensp
ENSMUSP00000163309
resolver
enst
ENSMUST00000035106
resolver
genesymbol
Slc25a38
resolver
uniprot_entry
S2538_MOUSE
resolver
amino_acid_sequence
MGVSAEPRSLSVAGAGLASPVIEKARSALLQSQDVEDTVETLMLHPVIKAFLCGSISGTCSTLLFQPLDLLKTRLQALQPSDLGPRRVGMLAVFLKVVRTESLLGLWKGMSPSIVRCVPGVGIYFGTLYSSKQYFLRGHPPTALESVILGMGSRSVAGVCMSPITVIKTRYESGTYSYESIYAALRSIYCSEGHRGLFRGLTATLLRDAPFSGLYLMFYSQTRTAVLHGTAQLDAALIPLINFSCGIFAGVLASLVTQPADVIKTHMQLSPVKFQWIGQAATLIFKNHGLRGFFHGSVPRALRRTLMAAMAWTVYEEMMARMGLKS
uniprot
proteins
function
FUNCTION: Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis. {ECO:0000255|HAMAP-Rule:MF_03064}.; FUNCTION: Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis. {ECO:0000269|PubMed:23115192}.
uniprot
proteins
mass_dalton
35390
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
protein_family
SLC25A38 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23115192
uniprot
proteins
sequence_length
326
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:23115192}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03064}.
uniprot
proteins
transmembrane_region
TRANSMEM 51..76; /note="Helical; Name=1"; /evidence="ECO:0000255|HAMAP-Rule:MF_03064"; TRANSMEM 109..135; /note="Helical; Name=2"; /evidence="ECO:0000255|HAMAP-Rule:MF_03064"; TRANSMEM 147..172; /note="Helical; Name=3"; /evidence="ECO:0000255|HAMAP-Rule:MF_03064"; TRANSMEM 200..223; /note="Helical; Name=4"; /evidence="ECO:0000255|HAMAP-Rule:MF_03064"; TRANSMEM 241..267; /note="Helical; Name=5"; /evidence="ECO:0000255|HAMAP-Rule:MF_03064"; TRANSMEM 296..314; /note="Helical; Name=6"; /evidence="ECO:0000255|HAMAP-Rule:MF_03064
uniprot
proteins