Mrgprb2
entrez
243979
canonical
uniprot
Q3KNA1
canonical
ensembl
ENSMUSG00000050425
resolver
ensp
ENSMUSP00000061878
resolver
enst
ENSMUST00000052730
resolver
genesymbol
Mrgprb2
resolver
genesymbol_syn
Mrgb2
resolver
uniprot
Q8CDY4
resolver
uniprot
Q91ZC2
resolver
uniprot_entry
MRGB2_MOUSE
resolver
uniprot_sec
Q8CDY4
resolver
uniprot_sec
Q91ZC2
resolver
amino_acid_sequence
MSGDFLIKNLSTSAWKTNITVLNGSYYIDTSVCVTRNQAMILLSIIISLVGMGLNAIVLWFLGIRMHTNAFTVYILNLAMADFLYLCSQFVICLLIAFYIFYSIDINIPLVLYVVPIFAYLSGLSILSTISIERCLSVIWPIWYRCKRPRHTSAITCFVLWVMSLLLGLLEGKACGLLFNSFDSYWCETFDVITNIWSVVFFGVLCGSSLTLLVRIFCGSQRIPMTRLYVTITLTVLVFLIFGLPFGIYWILYQWISNFYYVEICNFYLEILFLSCVNSCMNPIIYFLVGSIRHRRFRRKTLKLLLQRAMQDTPEEEQSGNKSSSEHPEELETVQSCS
uniprot
proteins
function
FUNCTION: Mast cell-specific G protein-coupled receptor for basic secretagogues, which regulates mast cell degranulation and itch-related hypersensitivity reactions (PubMed:25517090). A secretagogue is an agent that promotes the secretion of hormones, neurohormones, chemical neurotransmitters or other compounds synthesized and secreted by cells (PubMed:25517090). Basic secretagogues comprise a set of cationic amphiphilic drugs, as well as endo- or exogenous peptides, consisting of a basic head group and a hydrophobic core (PubMed:25517090). Recognizes and binds small molecules containing a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs), including tubocurarine and atracurium. In response to these compounds, mediates pseudo-allergic reactions characterized by histamine release, inflammation and airway contraction (PubMed:25517090). Acts as a receptor for substance P, a basic secretagogue neuropeptide released from the terminals of specific sensory nerves, initiating a signaling that mediates neurogenic inflammation and pain (PubMed:30686732). Neurogenic inflammation includes mast cell activation, recruitment of immune cells and release of inflammatory mediators, such as cytokines and chemokines (PubMed:30686732). {ECO:0000269|PubMed:25517090, ECO:0000269|PubMed:30686732}.
uniprot
proteins
mass_dalton
38832
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Mas subfamily
uniprot
proteins
pubmed
11551509
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
25517090
uniprot
proteins
pubmed
30686732
uniprot
proteins
sequence_length
338
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 41..61; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 90..110; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 112..132; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 158..178; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 192..212; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 232..252; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 269..289; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins