Rftn2
entrez
74013
canonical
uniprot
Q8CHX7
canonical
ensembl
ENSMUSG00000025978
resolver
ensp
ENSMUSP00000027121
resolver
ensp
ENSMUSP00000233842
resolver
ensp
ENSMUSP00000233850
resolver
ensp
ENSMUSP00000233851
resolver
genesymbol
Rftn2
resolver
uniprot
Q8R306
resolver
uniprot
Q9CXJ5
resolver
uniprot_entry
RFTN2_MOUSE
resolver
uniprot_sec
Q8R306
resolver
uniprot_sec
Q9CXJ5
resolver
amino_acid_sequence
MGCGLRKLEDPDESSPGKIFSTLKRPQVETKTEFAYEYALLDFTLQASTNPDVIKINSVLDIVAKVEDYYLKGYVVGAIHPVIQPVGQRKHLPASHLYRAVLSRLKLSPKHSAAGGQRRARLVMEECPLTCEAQANDAAKELMDKINAAAKRGMKFVGLVSQCYLPSMHCNGASHDGVAESGLHVRQDSQDNCKGWNEGALGGHLSESGVEEEPQHESGQHQTERNSSPSYANPKRGEAPDGKLYMVFNAFEEDAASWAYQEGVLSMKVTRKGAVISALDANWLELTTFYYKQGFSLIDSFVCWETPKGDQLPKSLEGFFIYEEEGSGVPGSNRRGNDAIVVEQWTVIEGCEIKTDYGPLLHTLAEFGWLLTSVLPTPILRHDSEGNLATKQVVFLQRPVTWNSAAQTPERKGSRLLKGEDRNKVSSRSLGLDTNASQAAGGRAPLEEGSLSPSRECWTKEERPAQSDSFSGFSSSDSVLRELDDGQFDQEEGVTQVTCM
uniprot
proteins
function
FUNCTION: Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production (PubMed:27022195). May regulate B-cell antigen receptor-mediated signaling. {ECO:0000269|PubMed:19414744, ECO:0000269|PubMed:27022195}.
uniprot
proteins
mass_dalton
54972
uniprot
proteins
protein_family
Raftlin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19414744
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27022195
uniprot
proteins
sequence_length
500
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q14699}; Lipid-anchor {ECO:0000250|UniProtKB:Q14699}.
uniprot
proteins