MPP7
entrez
143098
canonical
uniprot
Q5T2T1
canonical
ensembl
ENSG00000150054
resolver
ensp
ENSP00000364871
resolver
ensp
ENSP00000364884
resolver
ensp
ENSP00000507917
resolver
ensp
ENSP00000563221
resolver
ensp
ENSP00000563228
resolver
ensp
ENSP00000563229
resolver
ensp
ENSP00000777842
resolver
ensp
ENSP00000785546
resolver
genesymbol
MPP7
resolver
hgnc
HGNC:26542
resolver
uniprot
B2RCC9
resolver
uniprot
B4DWL9
resolver
uniprot
B5MDZ3
resolver
uniprot
D3DRW3
resolver
uniprot
Q5T2T0
resolver
uniprot
Q8IY28
resolver
uniprot_entry
MPP7_HUMAN
resolver
uniprot_sec
B2RCC9
resolver
uniprot_sec
B4DWL9
resolver
uniprot_sec
B5MDZ3
resolver
uniprot_sec
D3DRW3
resolver
uniprot_sec
Q5T2T0
resolver
uniprot_sec
Q8IY28
resolver
amino_acid_sequence
MPALSTGSGSDTGLYELLAALPAQLQPHVDSQEDLTFLWDMFGEKSLHSLVKIHEKLHYYEKQSPVPILHGAAALADDLAEELQNKPLNSEIRELLKLLSKPNVKALLSVHDTVAQKNYDPVLPPMPEDIDDEEDSVKIIRLVKNREPLGATIKKDEQTGAIIVARIMRGGAADRSGLIHVGDELREVNGIPVEDKRPEEIIQILAQSQGAITFKIIPGSKEETPSKEGKMFIKALFDYNPNEDKAIPCKEAGLSFKKGDILQIMSQDDATWWQAKHEADANPRAGLIPSKHFQERRLALRRPEILVQPLKVSNRKSSGFRKSFRLSRKDKKTNKSMYECKKSDQYDTADVPTYEEVTPYRRQTNEKYRLVVLVGPVGVGLNELKRKLLISDTQHYGVTVPHTTRARRSQESDGVEYIFISKHLFETDVQNNKFIEYGEYKNNYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNAKIISSRDDQGAAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELKTTFDKLETETHWVPVSWLHS
uniprot
proteins
function
FUNCTION: Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact. {ECO:0000269|PubMed:17332497}.
uniprot
proteins
mass_dalton
65524
uniprot
proteins
mutagenesis
MUTAGEN 38; /note="L->S: Abolishes interaction with DLG1."; /evidence="ECO:0000269|PubMed:17332497"; MUTAGEN 95; /note="L->S: Does not affect the interaction with DLG1."; /evidence="ECO:0000269|PubMed:17332497
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by aPKC which promotes dissociation from the cell cortex. {ECO:0000269|PubMed:26481050}.
uniprot
proteins
protein_family
MAGUK family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14719143
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16678097
uniprot
proteins
pubmed
17237226
uniprot
proteins
pubmed
17332497
uniprot
proteins
pubmed
17616219
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20702775
uniprot
proteins
pubmed
26481050
uniprot
proteins
sequence_length
576
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein {ECO:0000269|PubMed:17332497}. Lateral cell membrane; Peripheral membrane protein {ECO:0000269|PubMed:17332497}. Cell junction, tight junction {ECO:0000269|PubMed:17237226, ECO:0000269|PubMed:17332497}. Cell junction, adherens junction {ECO:0000269|PubMed:17237226, ECO:0000269|PubMed:17332497}. Cytoplasm, cell cortex {ECO:0000269|PubMed:26481050}. Cytoplasm {ECO:0000269|PubMed:26481050}. Note=In epidermal cells, detected primarily at the lateral cell membrane. {ECO:0000269|PubMed:17332497}.
uniprot
proteins