Dhrs7c
entrez
68460
canonical
uniprot
Q8CHS7
canonical
ensembl
ENSMUSG00000033044
resolver
ensp
ENSMUSP00000130924
resolver
enst
ENSMUST00000168612
resolver
genesymbol
Dhrs7c
resolver
genesymbol_syn
Sdr32c2
resolver
genesymbol_syn
Srp-35
resolver
uniprot
B1ATJ2
resolver
uniprot_entry
DRS7C_MOUSE
resolver
uniprot_sec
B1ATJ2
resolver
amino_acid_sequence
MGLMAVLMLPLLLLGISGLLFIYQEASRLWSKSAVQNKVVVITDAISGLGKECARVFHAGGARLVLCGKNWEGLESLYATLTSVADPSKTFTPKLVLLDLSDISCVQDVAKEVLDCYGCVDILINNASVKVKGPAHKISLELDKKIMDANYFGPITLTKVLLPNMISRRTGQIVLVNNIQAKFGIPFRTAYAASKHAVMGFFDCLRAEVEEYDVVVSTVSPTFIRSYRASPEQRNWETSICKFFCRKLAYGVHPVEVAEEVMRTVRRKKQEVFMANPVPKAAVFIRTFFPEFFFAVVACGVKEKLNVPEEG
uniprot
proteins
ec_number
1.1.1.105
uniprot
proteins
function
FUNCTION: NADH-dependent oxidoreductase which catalyzes the oxidation of all-trans-retinol to all-trans-retinal (PubMed:21995425). Plays a role in the regulation of cardiac and skeletal muscle metabolic functions (Probable) (PubMed:21995425, PubMed:27806939, PubMed:29330505). Maintains Ca(2+) intracellular homeostasis by repressing Ca(2+) release from the sarcoplasmic reticulum (SR) in myotubes, possibly through local alternations in NAD/NADH or retinol/retinal (PubMed:21995425). Also plays a role in Ca(2+) homeostasis by controlling Ca(2+) overload in the cytosol and the SR in myotubes (PubMed:27806939). Involved in glucose uptake into skeletal muscles and muscle performance by activating PI3K and mTORC2-mediated AKT1 phosphorylation signaling pathways, possibly through the action of its downstream catalytic product all-trans-retinoic acid (PubMed:29330505). {ECO:0000269|PubMed:21995425, ECO:0000269|PubMed:27806939, ECO:0000269|PubMed:29330505, ECO:0000305|PubMed:22143674}.
uniprot
proteins
mass_dalton
34468
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21995425
uniprot
proteins
pubmed
22143674
uniprot
proteins
pubmed
27806939
uniprot
proteins
pubmed
29330505
uniprot
proteins
sequence_length
311
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane {ECO:0000305|PubMed:21995425, ECO:0000305|PubMed:22143674, ECO:0000305|PubMed:27806939}. Note=The N-terminus region encompasses a short hydrophobic sequence bound to the sarcoplasmic reticulum membrane, whereas the C-terminus catalytic domain faces the myoplasm. In skeletal muscle, enriched in the longitudinal sarcoplasmic reticulum (PubMed:21995425). {ECO:0000269|PubMed:21995425, ECO:0000305|PubMed:21995425}.
uniprot
proteins