Ints12
entrez
295448
canonical
uniprot
Q68FR3
canonical
ensembl
ENSRNOG00000011844
resolver
ensp
ENSRNOP00000016066
resolver
ensp
ENSRNOP00000088831
resolver
enst
ENSRNOT00000016066
resolver
enst
ENSRNOT00000116296
resolver
genesymbol
Ints12
resolver
genesymbol_syn
Phf22
resolver
uniprot
A0A0H2UHJ4
resolver
uniprot_entry
A0A0H2UHJ4_RAT
resolver
uniprot_entry
INT12_RAT
resolver
amino_acid_sequence
MAATVNLELDPIFLKALGFLHSKSKDSAEKLKTLLDESLARGIDASYRPAQKDVEPPKISSTKSLSIKQEPKTSSSLPSGSSNGKVLAAEKLKKEAEKRPADKMKDATEGVDVPKKPRLEKPETRSSPITVQTSKDLAMADLSSFEETSADDFAMEMGLACVVCRQMTVASGNQLVECQECHNLYHQDCHKPQVTDKEVNDPRLVWYCARCTRQMKRMAQKTQKPPQKPAPTVVSVAPTVKDPLVKKPETKLKQETTFLAFKRTEVKPSTVISGNSSSNNVSSSVTSGLTGWAAFAAKTSSAGPSTAKLNSTAQNSSGKPAASSASQKPVGLTGLATSSKGGIGSKIGSSNSTSPSVPLKPLPPLTLGKTGLSRSVSCDNVSKVGLPSPSSLVPGGSSQLSGNGNSATAGPTGSITSKTTSETSSSTSASLKGPTSQESQLNAMKRLQMVKKKAAQKKLKK
uniprot
proteins
function
FUNCTION: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the integrator complex. {ECO:0000250|UniProtKB:Q96CB8}.
uniprot
proteins
mass_dalton
48477
uniprot
proteins
post_translational_modification
PTM: Dephosphorylated at Ser-127 by the PNUTS-PP1 complex, promoting RNA polymerase II transcription pause-release. {ECO:0000250|UniProtKB:Q96CB8}.
uniprot
proteins
protein_family
Integrator subunit 12 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
461
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96CB8}.
uniprot
proteins