Asap2
entrez
211914
canonical
uniprot
Q7SIG6
canonical
ensembl
ENSMUSG00000052632
resolver
ensp
ENSMUSP00000054631
resolver
ensp
ENSMUSP00000063217
resolver
ensp
ENSMUSP00000099098
resolver
enst
ENSMUST00000050990
resolver
enst
ENSMUST00000064595
resolver
genesymbol
Asap2
resolver
genesymbol_syn
Ddef2
resolver
genesymbol_syn
Gm1523
resolver
genesymbol_syn
Gm592
resolver
genesymbol_syn
Itgb1bp1
resolver
uniprot
D3YX85
resolver
uniprot
E9PX52
resolver
uniprot
Q3UH27
resolver
uniprot
Q501K1
resolver
uniprot
Q66JN2
resolver
uniprot_entry
ASAP2_MOUSE
resolver
uniprot_entry
D3YX85_MOUSE
resolver
uniprot_entry
E9PX52_MOUSE
resolver
uniprot_entry
Q3UH27_MOUSE
resolver
uniprot_sec
Q501K1
resolver
uniprot_sec
Q66JN2
resolver
amino_acid_sequence
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKAINISGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDYETKITKIEKEKKEHAKLHGMIRTEISGAEIAEEMEKERRFFQLQMCEYLLKVNEIKVKKGVDLLQNLIKYFHAQCNFFQDGLKAVESLKPSIETLSTDLHTIKQAQDEERRQLIQLRDILKSALQVEQKESRRDSQLRQSTAYSLHQPQGNKEHGTERNGNLYKKSDGIRKVWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQVKTNPEEKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTKEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLAKNIGNAGFNEIMECCLPSEDPVKPNPGSDMIARKDYITAKYMERRYARKKHADTAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDIAKRLKHEHCEELLTQALSGRFNSHVHVEYEWRLLHEDLDESDDDVDEKLQPSPNRREDRPVSFYQLGSSQFQSNAVSLARDTANLTKDKQRGFGPSILQNETYGAILSGSPPSSQSIPPSTTSAPPLPPRNVGKDPLTTTPPPPVAKTSGTLEAMNQPSKSSQPGTSQSKPPPLPPQPPSRLPQKKPASGTDKPTPLTNKGQPRGPEASGPLSNAMALQPPAPMPRKSQATKSKPKRVKALYNCVADNPDELTFSEGDVIIVDGEEDQEWWIGHIDGEPSRKGAFPVSFVHFIAD
uniprot
proteins
function
FUNCTION: Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration (By similarity). {ECO:0000250, ECO:0000269|PubMed:10022920, ECO:0000269|PubMed:11304556}.
uniprot
proteins
mass_dalton
106805
uniprot
proteins
mutagenesis
MUTAGEN 449; /note="W->A: Strongly reduces Arf-GAP mediated stimulation of GTP hydrolysis."; /evidence="ECO:0000269|PubMed:10601011"; MUTAGEN 460; /note="I->A: Reduces Arf-GAP mediated stimulation of GTP hydrolysis 100-fold and abolishes Arf-GAP mediated stimulation of GTP hydrolysis; when associated with A-306."; /evidence="ECO:0000269|PubMed:10601011"; MUTAGEN 467; /note="R->A: Abolishes Arf-GAP mediated stimulation of GTP hydrolysis."; /evidence="ECO:0000269|PubMed:10601011"; MUTAGEN 467; /note="R->K: Reduces Arf-GAP mediated stimulation of GTP hydrolysis more than 10000-fold."; /evidence="ECO:0000269|PubMed:10601011"; MUTAGEN 481; /note="L->A: Reduces Arf-GAP mediated stimulation of GTP hydrolysis 100-fold and abolishes Arf-GAP mediated stimulation of GTP hydrolysis; when associated with A-285."; /evidence="ECO:0000269|PubMed:10601011"; MUTAGEN 482; /note="D->A: Reduces Arf-GAP mediated stimulation of GTP hydrolysis 1000-fold."; /evidence="ECO:0000269|PubMed:10601011
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues by SRC and PTK2B. {ECO:0000250}.
uniprot
proteins
pubmed
10022920
uniprot
proteins
pubmed
10601011
uniprot
proteins
pubmed
11304556
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
958
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Note=Colocalizes with F-actin and ARF6 in phagocytic cups.
uniprot
proteins