Slc13a3
entrez
114644
canonical
uniprot
Q91Y63
canonical
ensembl
ENSMUSG00000018459
resolver
ensp
ENSMUSP00000029208
resolver
enst
ENSMUST00000029208
resolver
genesymbol
Slc13a3
resolver
genesymbol_syn
Nadc3
resolver
genesymbol_syn
Sdct2
resolver
uniprot
Q3UUJ6
resolver
uniprot_entry
Q3UUJ6_MOUSE
resolver
uniprot_entry
S13A3_MOUSE
resolver
amino_acid_sequence
MAALAALAKKVWSARRLLVLLLVPLALLPILFALPPKEGRCLYVILLMAVYWCTEALPLSVTALLPIILFPFMGILPSSKVCPQYFLDTNFLFLSGLIMASAIEEWNLHRRIALKVLMLVGVQPARLILGMMVTTSFLSMWLSNTASTAMMLPIASAILKSLFGQREARKDLPREGDESTAAVQGNGLRTVPTEMQFLASSEGGHTEDAEAPMELPDDSKEEEHRRNIWKGFLISIPYSASIGGTATLTGTAPNLILLGQLKSFFPQCDVVNFGSWFIFAFPLMLLFLLVGWLWISFLYGGMSWRSWRKKKSKIRADAEDQAKAVIQEEFQNLGPIKFAEQAVFILFCTFAILLFSRDPKFIPGWASLFAPGFVSDAVTGVAIVTILFFFPSQKPSLKWWFDFKAPNSETEPLLSWKKAQETVPWNIILLLGGGFAMAKGCEESGLSAWIGGQLHPLEHVPPLLAVLLITVVIAFFTEFASNTATIIIFLPVLAELAIRLHVHPLYLMIPGTVGCSYAFMLPVSTPPNSIAFSTGHLLVKDMVRTGLLMNLMGVLLLSLAMNTWAQTIFQLGTFPDWANTHAANATALPPALTNNTVQTF
uniprot
proteins
function
FUNCTION: High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-6 carbon atoms, such as the citric acid cycle intermediates succinate and alpha-ketoglutarate (2-oxoglutarate), as well as other compounds including N-acetyl-L-aspartate (PubMed:11287335). Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic (PubMed:11287335). Can transport citrate in a Na(+)-dependent manner, recognizing the divalent form of citrate rather than the trivalent form which is normally found in blood (By similarity). Imports itaconate in hepatocytes leading to activation of TFEB-dependent lysosomal biogenesis involved in antibacterial innate immune response (PubMed:39116875). {ECO:0000250|UniProtKB:Q8WWT9, ECO:0000269|PubMed:11287335, ECO:0000269|PubMed:39116875}.
uniprot
proteins
mass_dalton
66143
uniprot
proteins
protein_family
NADC subfamily
uniprot
proteins
protein_family
SLC13A/DASS transporter (TC 2.A.47) family
uniprot
proteins
pubmed
11287335
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
39116875
uniprot
proteins
sequence_length
600
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8WWT9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8WWT9}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..33; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q8WWT9"; TRANSMEM 36..54; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q8WWT9"; TRANSMEM 59..72; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q8WWT9"; TRANSMEM 78..120; /note="Discontinuously helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q8WWT9"; TRANSMEM 218..264; /note="Discontinuously helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q8WWT9"; TRANSMEM 273..332; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q8WWT9"; TRANSMEM 338..355; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q8WWT9"; TRANSMEM 376..388; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q8WWT9"; TRANSMEM 416..457; /note="Discontinuously helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q8WWT9"; TRANSMEM 504..534; /note="Discontinuously helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q8WWT9"; TRANSMEM 539..569; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q8WWT9
uniprot
proteins