ASMTL
entrez
8623
canonical
uniprot
O95671
canonical
ensembl
ENSG00000169093
resolver
ensembl
ENSG00000292339
resolver
ensp
ENSP00000370718
resolver
ensp
ENSP00000370734
resolver
ensp
ENSP00000446410
resolver
ensp
ENSP00000518598
resolver
ensp
ENSP00000815734
resolver
ensp
ENSP00000815742
resolver
genesymbol
ASMTL
resolver
hgnc
HGNC:751
resolver
uniprot
B3KM43
resolver
uniprot
B4DX75
resolver
uniprot
F5GXH4
resolver
uniprot
J3JS33
resolver
uniprot
Q5JQ53
resolver
uniprot
Q8NBH5
resolver
uniprot
Q96G02
resolver
uniprot
Q9BUL6
resolver
uniprot_entry
ASML_HUMAN
resolver
uniprot_entry
B3KM43_HUMAN
resolver
uniprot_sec
B4DX75
resolver
uniprot_sec
F5GXH4
resolver
uniprot_sec
J3JS33
resolver
uniprot_sec
Q5JQ53
resolver
uniprot_sec
Q8NBH5
resolver
uniprot_sec
Q96G02
resolver
uniprot_sec
Q9BUL6
resolver
amino_acid_sequence
MVLCPVIGKLLHKRVVLASASPRRQEILSNAGLRFEVVPSKFKEKLDKASFATPYGYAMETAKQKALEVANRLYQKDLRAPDVVIGADTIVTVGGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHCSSKDHQLDTRVSEFYEETKVKFSELSEELLWEYVHSGEPMDKAGGYGIQALGGMLVESVHGDFLNVVGFPLNHFCKQLVKLYYPPRPEDLRRSVKHDSIPAADTFEDLSDVEGGGSEPTQRDAGSRDEKAEAGEAGQATAEAECHRTRETLPPFPTRLLELIEGFMLSKGLLTACKLKVFDLLKDEAPQKAADIASKVDASACGMERLLDICAAMGLLEKTEQGYSNTETANVYLASDGEYSLHGFIMHNNDLTWNLFTYLEFAIREGTNQHHRALGKKAEDLFQDAYYQSPETRLRFMRAMHGMTKLTACQVATAFNLSRFSSACDVGGCTGALARELAREYPRMQVTVFDLPDIIELAAHFQPPGPQAVQIHFAAGDFFRDPLPSAELYVLCRILHDWPDDKVHKLLSRVAESCKPGAGLLLVETLLDEEKRVAQRALMQSLNMLVQTEGKERSLGEYQCLLELHGFHQVQVVHLGGVLDAILATKVAP
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
ec_number
3.6.1.9
uniprot
proteins
function
FUNCTION: Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-UTP (m(5)UTP) and 5-methyl-CTP (m(5)CTP). Has weak activity with dCTP, 8-oxo-GTP and N(4)-methyl-dCTP (PubMed:24210219). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219). In addition, the presence of the putative catalytic domain of S-adenosyl-L-methionine binding in the C-terminal region argues for a methyltransferase activity (Probable). {ECO:0000269|PubMed:24210219, ECO:0000305}.
uniprot
proteins
mass_dalton
68857
uniprot
proteins
mutagenesis
MUTAGEN 19; /note="S->A: Loss of pyrophosphatase activity."; /evidence="ECO:0000269|PubMed:24210219"; MUTAGEN 21; /note="S->A: Loss of pyrophosphatase activity."; /evidence="ECO:0000269|PubMed:24210219"; MUTAGEN 23; /note="R->A: Decrease in pyrophosphatase activity."; /evidence="ECO:0000269|PubMed:24210219"; MUTAGEN 24; /note="R->A: Loss of pyrophosphatase activity."; /evidence="ECO:0000269|PubMed:24210219"; MUTAGEN 44; /note="E->A: Loss of pyrophosphatase activity."; /evidence="ECO:0000269|PubMed:24210219"; MUTAGEN 57; /note="Y->A: Loss of pyrophosphatase activity."; /evidence="ECO:0000269|PubMed:24210219"; MUTAGEN 65; /note="K->A: Loss of pyrophosphatase activity."; /evidence="ECO:0000269|PubMed:24210219"; MUTAGEN 88; /note="D->A,N: Loss of pyrophosphatase activity."; /evidence="ECO:0000269|PubMed:24210219"; MUTAGEN 99; /note="E->A: Loss of pyrophosphatase activity."; /evidence="ECO:0000269|PubMed:24210219"; MUTAGEN 179; /note="Q->A: Loss of pyrophosphatase activity."; /evidence="ECO:0000269|PubMed:24210219"; MUTAGEN 179; /note="Q->E: Strong decrease in pyrophosphatase activity."; /evidence="ECO:0000269|PubMed:24210219
uniprot
proteins
protein_family
Cation-independent O-methyltransferase family
uniprot
proteins
protein_family
Maf family
uniprot
proteins
protein_family
YhdE subfamily; Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24210219
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9736779
uniprot
proteins
sequence_length
621
uniprot
proteins