CSKMT
entrez
751071
canonical
uniprot
A8MUP2
canonical
ensembl
ENSG00000214756
resolver
ensp
ENSP00000431287
resolver
ensp
ENSP00000583156
resolver
enst
ENST00000532971
resolver
enst
ENST00000913097
resolver
genesymbol
CSKMT
resolver
genesymbol_syn
METTL12
resolver
hgnc
HGNC:33113
resolver
uniprot
B7Z4C1
resolver
uniprot_entry
CSKMT_HUMAN
resolver
uniprot_sec
B7Z4C1
resolver
activity_regulation
ACTIVITY REGULATION: Citrate synthase-lysine methyltransferase activity is inhibited by S-adenosylhomocysteine (AdoHcy) and oxaloacetate (OAA) (PubMed:28887308). {ECO:0000269|PubMed:28887308}.
uniprot
proteins
amino_acid_sequence
MAALRRMLHLPSLMMGTCRPFAGSLADSCLADRCLWDRLHAQPRLGTVPTFDWFFGYDEVQGLLLPLLQEAQAASPLRVLDVGCGTSSLCTGLYTKSPHPVDVLGVDFSPVAVAHMNSLLEGGPGQTPLCPGHPASSLHFMHADAQNLGAVASSGSFQLLLDKGTWDAVARGGLPRAYQLLSECLRVLNPQGTLIQFSDEDPDVRLPCLEQGSYGWTVTVQELGPFRGITYFAYLIQGSH
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Protein-lysine methyltransferase that selectively trimethylates citrate synthase (CS) in mitochondria (PubMed:28391595, PubMed:28887308). Seems to conduct trimethylation in a highly distributive manner rather than in a processive manner, and thus introduces a single methyl group per binding event (PubMed:28887308). {ECO:0000269|PubMed:28391595, ECO:0000269|PubMed:28887308}.
uniprot
proteins
mass_dalton
25910
uniprot
proteins
mutagenesis
MUTAGEN 107; /note="D->A: Inhibits citrate synthase-lysine methyltransferase activity."; /evidence="ECO:0000269|PubMed:28887308
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
25023281
uniprot
proteins
pubmed
28391595
uniprot
proteins
pubmed
28887308
uniprot
proteins
sequence_length
240
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:25023281, ECO:0000269|PubMed:28887308}.
uniprot
proteins