MYG1
entrez
60314
canonical
uniprot
Q9HB07
canonical
ensembl
ENSG00000139637
resolver
ensembl
ENSG00000291835
resolver
ensp
ENSP00000267103
resolver
ensp
ENSP00000517432
resolver
enst
ENST00000267103
resolver
enst
ENST00000708949
resolver
genesymbol
MYG1
resolver
genesymbol_syn
C12orf10
resolver
hgnc
HGNC:17590
resolver
uniprot
Q86UA3
resolver
uniprot_entry
MYG1_HUMAN
resolver
uniprot_sec
Q86UA3
resolver
amino_acid_sequence
MGHRFLRGLLTLLLPPPPLYTRHRMLGPESVPPPKRSRSKLMAPPRIGTHNGTFHCDEALACALLRLLPEYRDAEIVRTRDPEKLASCDIVVDVGGEYDPRRHRYDHHQRSFTETMSSLSPGKPWQTKLSSAGLIYLHFGHKLLAQLLGTSEEDSMVGTLYDKMYENFVEEVDAVDNGISQWAEGEPRYALTTTLSARVARLNPTWNHPDQDTEAGFKRAMDLVQEEFLQRLDFYQHSWLPARALVEEALAQRFQVDPSGEIVELAKGACPWKEHLYHLESGLSPPVAIFFVIYTDQAGQWRIQCVPKEPHSFQSRLPLPEPWRGLRDEALDQVSGIPGCIFVHASGFIGGHRTREGALSMARATLAQRSYLPQIS
uniprot
proteins
disease_involvement
DISEASE: Note=Several works have found that mRNA expression is elevated in the skin of vitiligo patients. {ECO:0000269|PubMed:20377893, ECO:0000269|PubMed:30051642, ECO:0000269|PubMed:31081026}.
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: 3'-5' RNA exonuclease which cleaves in situ on specific transcripts in both nucleus and mitochondrion. Involved in regulating spatially segregated organellar RNA processing, acts as a coordinator of nucleo-mitochondrial crosstalk (PubMed:31081026). In nucleolus, processes pre-ribosomal RNA involved in ribosome assembly and alters cytoplasmic translation. In mitochondrial matrix, processes 3'-termini of the mito-ribosomal and messenger RNAs and controls translation of mitochondrial proteins (Probable). {ECO:0000269|PubMed:31081026, ECO:0000305|PubMed:31081026}.
uniprot
proteins
mass_dalton
42508
uniprot
proteins
mutagenesis
MUTAGEN 106..108; /note="DHH->AAL: Catalytically inactive."; /evidence="ECO:0000269|PubMed:31081026"; MUTAGEN 344; /note="H->Q: Loss of RNase activity and gained single stranded DNase activity."; /evidence="ECO:0000269|PubMed:31081026
uniprot
proteins
protein_family
MYG1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
19014353
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20377893
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
30051642
uniprot
proteins
pubmed
31081026
uniprot
proteins
sequence_length
376
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:19014353, ECO:0000269|PubMed:20377893}. Mitochondrion matrix {ECO:0000269|PubMed:19014353, ECO:0000269|PubMed:20377893}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q9JK81}.
uniprot
proteins