Arl6
entrez
56297
canonical
uniprot
O88848
canonical
ensembl
ENSMUSG00000022722
resolver
ensp
ENSMUSP00000023405
resolver
ensp
ENSMUSP00000097238
resolver
genesymbol
Arl6
resolver
genesymbol_syn
ARL6
resolver
genesymbol_syn
Bbs3
resolver
uniprot
Q3TUM2
resolver
uniprot
Q3TY77
resolver
uniprot_entry
ARL6_MOUSE
resolver
uniprot_entry
Q3TUM2_MOUSE
resolver
uniprot_sec
Q3TY77
resolver
amino_acid_sequence
MGLLDRLSGLLGLKKKEVHVLCLGLDNSGKTTIINKLKPSNAQSQDIVPTIGFSIEKFKSSSLSFTVFDMSGQGRYRNLWEHYYKDGQAIIFVIDSSDKLRMVVAKEELDTLLNHPDIKHRRIPILFFANKMDLRDSVTSVKVSQLLCLESIKDKPWHICASDAIKGEGLQEGVDWLQDQIQAVKT
uniprot
proteins
function
FUNCTION: Involved in membrane protein trafficking at the base of the ciliary organelle (By similarity). Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia (By similarity). Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia (PubMed:24939912). Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation (By similarity). May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade (By similarity). Isoform 2 may be required for proper retinal function and organization (PubMed:20333246). {ECO:0000250|UniProtKB:Q9H0F7, ECO:0000269|PubMed:20333246, ECO:0000269|PubMed:24939912}.
uniprot
proteins
mass_dalton
20959
uniprot
proteins
protein_family
Arf family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10508919
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20333246
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24939912
uniprot
proteins
sequence_length
186
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Note=Appears in a pattern of punctae flanking the microtubule axoneme that likely correspond to small membrane-associated patches. Localizes to the so-called ciliary gate where vesicles carrying ciliary cargo fuse with the membrane (By similarity). {ECO:0000250}.
uniprot
proteins