Fbxo9
entrez
71538
canonical
uniprot
Q8BK06
canonical
ensembl
ENSMUSG00000001366
resolver
ensp
ENSMUSP00000001402
resolver
ensp
ENSMUSP00000082419
resolver
genesymbol
Fbxo9
resolver
uniprot
Q8VDY6
resolver
uniprot
Q9D349
resolver
uniprot
Q9JJC5
resolver
uniprot_entry
FBX9_MOUSE
resolver
uniprot_sec
Q8VDY6
resolver
uniprot_sec
Q9D349
resolver
uniprot_sec
Q9JJC5
resolver
amino_acid_sequence
MSAEAEEDCHSDADRVGDEGNESPAERDLQAQLQMFRAQWMFELTPGVGSSHGETRPCRAGRSSMLKAAADTKGRQELAKEEKARELFLQAVEEEQNGALYEAIKFYRRAMQLVPDIEFKITYTRSPDGDGVGSGYIEENEDASKMADLLSYFQQQLTLQESVLKLCQPELETSQTHISVLPMEVLMYIFRWVVSSDLDLRSLEQLSLVCRGFYICARDPEIWRLACLKVWGRSCMKLVPYASWREMFLERPRVRFDGVYISKTTYIRQGEQSLDGFYRAWHQVEYYRYMRFFPDGHVMMLTTPEEPPSIVPRLRTRNTRTDAILLGHYRLSQDADNQTKVFAVITKKKEEKPLDHKYRYFRRVPVQEADHSFHVGLQLCSSGHQRFNKLIWIHHSCHITYKATGETAVSAFEIDKMYTPLLFARVRSYTAFSERPL
uniprot
proteins
function
FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Ubiquitinates mTORC1-bound TTI1 and TELO2 when they are phosphorylated by CK2 following growth factor deprivation, leading to their degradation. In contrast, does not mediate ubiquitination of TTI1 and TELO2 when they are part of the mTORC2 complex. As a consequence, mTORC1 is inactivated to restrain cell growth and protein translation, while mTORC2 is the activated due to the relief of feedback inhibition by mTORC1 (By similarity). Plays a role in maintaining epithelial cell survival by regulating the turn-over of chromatin modulator PRMT4 through ubiquitination and degradation by the proteasomal pathway (By similarity). Also regulates PPARgamma stability by facilitating PPARgamma/PPARG ubiquitination and thereby plays a role in adipocyte differentiation (PubMed:23643813, PubMed:27197753). {ECO:0000250|UniProtKB:Q9UK97, ECO:0000269|PubMed:23643813, ECO:0000269|PubMed:27197753}.
uniprot
proteins
mass_dalton
50760
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23643813
uniprot
proteins
pubmed
27197753
uniprot
proteins
sequence_length
437
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UK97}.
uniprot
proteins