Rbm7
entrez
67010
canonical
uniprot
Q9CQT2
canonical
ensembl
ENSMUSG00000042396
resolver
ensp
ENSMUSP00000126374
resolver
ensp
ENSMUSP00000303831
resolver
ensp
ENSMUSP00000303835
resolver
enst
ENSMUST00000170000
resolver
genesymbol
Rbm7
resolver
uniprot
Q14A95
resolver
uniprot
Q3U5M9
resolver
uniprot
Q3UB91
resolver
uniprot
Q7TQE3
resolver
uniprot_entry
Q14A95_MOUSE
resolver
uniprot_entry
Q3U5M9_MOUSE
resolver
uniprot_entry
RBM7_MOUSE
resolver
uniprot_sec
Q3UB91
resolver
uniprot_sec
Q7TQE3
resolver
amino_acid_sequence
MGAAAAEADRTLFVGNLETKVTEELLFELFHQAGPVIKVKIPKDKDGKLKQFAFVNFKHEVSVPYAMNLLNGIKLFGRPIKIQFRSGSSHASQDASVSYPQHHVGNLSPTSTSPNSYERTVGNVSPTAQMVQRSFSSPEDYQRQAVMNSVFRQMSYAGKFGSPHADQLGFSPSAQPHGHTFNQSSSSQWRQDALSSQRKRQNSHPYLADRHYSREQRYSDHGSDYHYRGSREDFYYDDRNHDGWSHDYDNRRDSSRGGKWPSSRH
uniprot
proteins
function
FUNCTION: RNA-binding subunit of the trimeric nuclear exosome targeting (NEXT) complex, a complex that functions as an RNA exosome cofactor that directs a subset of non-coding short-lived RNAs for exosomal degradation. NEXT is involved in surveillance and turnover of aberrant transcripts and non-coding RNAs. Binds preferentially polyuridine sequences and associates with newly synthesized RNAs, including pre-mRNAs and short-lived exosome substrates such as promoter upstream transcripts (PROMPTs), enhancer RNAs (eRNAs), and 3'-extended products from small nuclear RNAs (snRNAs). Participates in several biological processes including DNA damage response (DDR) and stress response. During stress response, activation of the p38MAPK-MK2 pathway decreases RBM7-RNA-binding and subsequently the RNA exosome degradation activities, thereby modulating the turnover of non-coding transcriptome. Participates in DNA damage response (DDR), through its interaction with MEPCE and LARP7, the core subunits of 7SK snRNP complex, that release the positive transcription elongation factor b (P-TEFb) complex from the 7SK snRNP. In turn, activation of P-TEFb complex induces the transcription of P-TEFb-dependent DDR genes to promote cell viability. {ECO:0000250|UniProtKB:Q9Y580}.
uniprot
proteins
mass_dalton
30148
uniprot
proteins
mutagenesis
MUTAGEN 136; /note="S->A: Does not phosphorylated by MAPK14/p38-alpha-activated MAPKAPK2/MK2. Does not affect localization. Does not affect interaction with ZCCHC8."; /evidence="ECO:0000269|PubMed:25525152
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-136 by MAPK14/p38-alpha-activated MAPKAPK2/MK2; this phosphorylation is stress-dependent; this phosphorylation decreases its RNA-binding capacity therefore affecting RNA nuclear exosome-mediated degradation (PubMed:25525152). This phosphorylation mediates YWHAE and YWHAZ interactions (By similarity). {ECO:0000250|UniProtKB:Q9Y580, ECO:0000269|PubMed:25525152}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25525152
uniprot
proteins
sequence_length
265
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9Y580}. Nucleus {ECO:0000269|PubMed:25525152}. Note=Excluded from the nucleolus. {ECO:0000250|UniProtKB:Q9Y580}.
uniprot
proteins