Tysnd1
entrez
71767
canonical
uniprot
Q9DBA6
canonical
ensembl
ENSMUSG00000020087
resolver
ensp
ENSMUSP00000020284
resolver
enst
ENSMUST00000020284
resolver
genesymbol
Tysnd1
resolver
uniprot
Q0VE90
resolver
uniprot_entry
TYSD1_MOUSE
resolver
uniprot_sec
Q0VE90
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by N-ethylmaleimide (NEM). Not affected by leupeptin or trans-epoxysuccinyl-l-leucylamido-(4-gianidino) butane (E64). {ECO:0000269|PubMed:17255948}.
uniprot
proteins
amino_acid_sequence
MGRQWGPSMRVAEQAGCVVSASRAGQPDAGSWSCSGVILSRNPGLVLCHGGIFTPFLRTGSAALTQTGTAFLPGDSCSDDLRLHVQWGPTAASPAGRADQELPGLCTPQCASLGLEPGAPSRARARPLQPPRPAQLLLLLSCPAFRSHFARLFGADAVDQWHFVSSAPDDAVSEEEEEDQLRALGWFALLRVQRGAAAEERRGPVVTVAPLGAVVKGAPLLACGSPFGAFCPDIFLNTLSRGVLSNAAGPLLLTDARCLPGTEGGGVFAARPAGALVALVAAPLCWKAREWVGLTLLCAAAPLLQVARWALARLHPGSASLSVLLPPPDVSTPRGLPLRDLGPPWAAAAVLVECGTVWGSGVVVAPRLVVTCRHVAPREAARVLVHSATPKNVAIWGQVVFATQETSPYDIAVVSLEEELNGVPTPVPAGHFHEGEPVSVVGFGVFGQACGPSVTSGILSAVVRVDGSPVMLQTTCAVHGGSSGGPLFSSGSGDLLGIVASNTRDNNTGATYPHLNFSIPITVLQPALKQYSQTGDLGGLRELDHTTEPVRVVWRLQRPLSEVPRSKL
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids (By similarity). {ECO:0000250, ECO:0000269|PubMed:17255948}.
uniprot
proteins
mass_dalton
59066
uniprot
proteins
post_translational_modification
PTM: Self-cleavage gives rise to an N-terminal 10-kDa fragment and C-terminal 49-kDa fragment upon import into the peroxisomes. The full-length TYSND1 is the active the proteolytic processing of PTS1- and PTS2-proteins and in self-cleavage, and intermolecular self-cleavage of TYSND1 down-regulates its protease activity. {ECO:0000269|PubMed:17255948}.
uniprot
proteins
protein_family
Peptidase S1B family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17255948
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
568
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome {ECO:0000269|PubMed:17255948}.
uniprot
proteins