L3mbtl3
entrez
237339
canonical
uniprot
Q8BLB7
canonical
ensembl
ENSMUSG00000039089
resolver
ensp
ENSMUSP00000037619
resolver
ensp
ENSMUSP00000101158
resolver
ensp
ENSMUSP00000133479
resolver
ensp
ENSMUSP00000281338
resolver
ensp
ENSMUSP00000281339
resolver
ensp
ENSMUSP00000281343
resolver
ensp
ENSMUSP00000281344
resolver
genesymbol
L3mbtl3
resolver
genesymbol_syn
Mbt1
resolver
uniprot
Q0VGT0
resolver
uniprot
Q641L7
resolver
uniprot
Q6ZPI2
resolver
uniprot
Q8C0G4
resolver
uniprot_entry
LMBL3_MOUSE
resolver
uniprot_sec
Q0VGT0
resolver
uniprot_sec
Q641L7
resolver
uniprot_sec
Q6ZPI2
resolver
uniprot_sec
Q8C0G4
resolver
amino_acid_sequence
MTESASSTSGQEFDVFSVMDWKDGVGTLPGSDLKFRVNEFGALEVITDESEMESVKKATATTTWMVPTAQDAPTSPPSSRPVFPPAYWTSPPGCPTVFSEKTGVPFRLKEQSKADGLQFCENCCQYGNGDECLSGGKYCSQNCARHAKDKDQKDERDGGEDNDEEDPKCSRKKKPKLSLKADSKDDGEERDDEMENKQDGRILRGSQRARRKRRGDSAVLKQGLPPKGKKTWCWASYLEEEKAVAVPTKLFKEHQSFPYNKNGFKVGMKLEGVDPDHQAMYCVLTVAEVCGYRIKLHFDGYSDCYDFWVNADALDIHPVGWCEKTGHKLRPPKGYKEEEFNWQSYLKTCKAQAAPKSLFENQNITVIPSGFRVGMKLEAADKKSPSVICVATVTDMVDNRFLVHFDNWDESYDYWCESNSPHIHPVGWCKEHRRTLITPPGYSHVKHFSWDKYLEETNSLPAPARAFKVKPPHGFQKKMKLEAVDKRNPLFIRVATVADTDDHRIKVHFDGWSSCYDYWIDADSPDIHPVGWCSKTGHPLQAPLSPAELMEPSETGGCPTLGCRGVGHFKKSRYLGTQSGANCPYSEINLSKERIFPDRLSGDTSPPTTPSFPRSKRMDTRESSSSPETREKHANNFKEDSEKKKENEVKTSAEAKVVREEPTPSVQQSQPPQQVQQVQHAQPPQQAQKAPQAQQAQQAQQAQQAPQAPQTPQPQQAPQVQQAQQAPQAQQAQQPQQAQQPQQAPPVQQPQQVQQAQPTQQQAQTQQQAQRRSAVFLSFKPPIPCLPLRWEQQSKLLPTVAGIPASRVSKWSTDEVSEFIQSLPGCEEHGKVFKDEQIDGEAFLLMTQTDIVKIMSIKLGPALKIFNSILMFKAAEKNSHNEL
uniprot
proteins
function
FUNCTION: Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression. It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation (By similarity). Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins (PubMed:30442713). Also involved in the regulation of ubiquitin-dependent degradation of methylated DNMT1 and E2F1 (By similarity). Required for normal maturation of myeloid progenitor cells. {ECO:0000250|UniProtKB:Q96JM7, ECO:0000269|PubMed:15889154, ECO:0000269|PubMed:30442713}.
uniprot
proteins
mass_dalton
99137
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15889154
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29030483
uniprot
proteins
pubmed
30442713
uniprot
proteins
pubmed
33980486
uniprot
proteins
sequence_length
883
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15889154, ECO:0000269|PubMed:33980486}.
uniprot
proteins