Mcrip1
entrez
360677
canonical
uniprot
B0BN72
canonical
ensembl
ENSRNOG00000036691
resolver
ensembl
ENSRNOG00055032795
resolver
ensembl
ENSRNOG00060008824
resolver
ensembl
ENSRNOG00060030495
resolver
ensembl
ENSRNOG00065003950
resolver
ensp
ENSRNOP00000051843
resolver
ensp
ENSRNOP00055046815
resolver
ensp
ENSRNOP00060011429
resolver
ensp
ENSRNOP00060044022
resolver
ensp
ENSRNOP00065004164
resolver
enst
ENSRNOT00000054960
resolver
enst
ENSRNOT00055056710
resolver
enst
ENSRNOT00060014777
resolver
enst
ENSRNOT00060052955
resolver
enst
ENSRNOT00065005779
resolver
genesymbol
Mcrip1
resolver
genesymbol_syn
Fam195b
resolver
uniprot_entry
MCRI1_RAT
resolver
amino_acid_sequence
MTSSPVSRVVYNGKRNSSPRSPTNSSEIFTPAHEENVRFIYEAWQGVERDLRSQLSSGERCLVEEYVEKVPNPSLKTFKPIDLSDLKRRNTQDAKKS
uniprot
proteins
function
FUNCTION: The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition. {ECO:0000250|UniProtKB:C9JLW8}.
uniprot
proteins
mass_dalton
11101
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by MAPK3/1 (ERK1/2) regulates MCRIP1 binding to CTBP(s). {ECO:0000250|UniProtKB:C9JLW8}.
uniprot
proteins
protein_family
MCRIP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
97
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:C9JLW8}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:C9JLW8}.
uniprot
proteins