Hpd
entrez
15445
canonical
uniprot
P49429
canonical
ensembl
ENSMUSG00000029445
resolver
ensp
ENSMUSP00000031398
resolver
enst
ENSMUST00000031398
resolver
genesymbol
Hpd
resolver
uniprot
P97322
resolver
uniprot
Q3UEQ0
resolver
uniprot
Q91WV9
resolver
uniprot_entry
HPPD_MOUSE
resolver
uniprot_sec
P97322
resolver
uniprot_sec
Q3UEQ0
resolver
uniprot_sec
Q91WV9
resolver
amino_acid_sequence
MTTYNNKGPKPERGRFLHFHSVTFWVGNAKQAASFYCNKMGFEPLAYRGLETGSREVVSHVIKQGKIVFVLCSALNPWNKEMGDHLVKHGDGVKDIAFEVEDCDHIVQKARERGAKIVREPWVEQDKFGKVKFAVLQTYGDTTHTLVEKINYTGRFLPGFEAPTYKDTLLPKLPRCNLEIIDHIVGNQPDQEMQSASEWYLKNLQFHRFWSVDDTQVHTEYSSLRSIVVTNYEESIKMPINEPAPGRKKSQIQEYVDYNGGAGVQHIALKTEDIITAIRHLRERGTEFLAAPSSYYKLLRENLKSAKIQVKESMDVLEELHILVDYDEKGYLLQIFTKPMQDRPTLFLEVIQRHNHQGFGAGNFNSLFKAFEEEQALRGNLTDLEPNGVRSGM
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Hpd are the cause of tyrosinemia type III.
uniprot
proteins
ec_number
1.13.11.27
uniprot
proteins
ec_number
2.1.1.348
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism. In addition may act as a N6-methyltransferase that methylates adenosine residues at the N(6) position of some RNAs. {ECO:0000250|UniProtKB:P32754}.
uniprot
proteins
mass_dalton
45054
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.
uniprot
proteins
protein_family
4HPPD family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1709870
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
7774914
uniprot
proteins
sequence_length
393
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P32754}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P32755}; Peripheral membrane protein {ECO:0000250|UniProtKB:P32755}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P32755}; Peripheral membrane protein {ECO:0000250|UniProtKB:P32755}. Nucleus {ECO:0000250|UniProtKB:P32754}.
uniprot
proteins