Lamp1
entrez
16783
canonical
uniprot
P11438
canonical
ensembl
ENSMUSG00000031447
resolver
ensp
ENSMUSP00000033824
resolver
ensp
ENSMUSP00000179160
resolver
enst
ENSMUST00000033824
resolver
genesymbol
Lamp1
resolver
genesymbol_syn
Lamp-1
resolver
uniprot
Q3TA96
resolver
uniprot
Q3TX84
resolver
uniprot
Q62020
resolver
uniprot
Q9DC13
resolver
uniprot_entry
LAMP1_MOUSE
resolver
uniprot_entry
Q3TA96_MOUSE
resolver
uniprot_entry
Q3TX84_MOUSE
resolver
uniprot_entry
Q9DC13_MOUSE
resolver
uniprot_sec
Q62020
resolver
amino_acid_sequence
MAAPGARRPLLLLLLAGLAHGASALFEVKNNGTTCIMASFSASFLTTYETANGSQIVNISLPASAEVLKNGSSCGKENVSDPSLTITFGRGYLLTLNFTKNTTRYSVQHMYFTYNLSDTEHFPNAISKEIYTMDSTTDIKADINKAYRCVSDIRVYMKNVTVVLRDATIQAYLSSGNFSKEETHCTQDGPSPTTGPPSPSPPLVPTNPTVSKYNVTGNNGTCLLASMALQLNITYLKKDNKTVTRAFNISPNDTSSGSCGINLVTLKVENKNRALELQFGMNASSSLFFLQGVRLNMTLPDALVPTFSISNHSLKALQATVGNSYKCNTEEHIFVSKMLSLNVFSVQVQAFKVDSDRFGSVEECVQDGNNMLIPIAVGGALAGLVLIVLIAYLIGRKRSHAGYQTI
uniprot
proteins
function
FUNCTION: Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis (PubMed:15121881). Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity (By similarity). Also plays an important role in NK-cells cytotoxicity (PubMed:23847195). Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule (By similarity). In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content (PubMed:23847195). Presents carbohydrate ligands to selectins (By similarity). Also implicated in tumor cell metastasis (PubMed:2676155). {ECO:0000250|UniProtKB:P11279, ECO:0000269|PubMed:15121881, ECO:0000269|PubMed:23847195, ECO:0000269|PubMed:2676155}.
uniprot
proteins
mass_dalton
43865
uniprot
proteins
post_translational_modification
PTM: O- and N-glycosylated; some of the N-glycans attached to LAMP-1 are polylactosaminoglycans. {ECO:0000250|UniProtKB:P11279}.
uniprot
proteins
protein_family
LAMP family
uniprot
proteins
pubmed
10212251
uniprot
proteins
pubmed
15121881
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16170054
uniprot
proteins
pubmed
16944957
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2142158
uniprot
proteins
pubmed
22641697
uniprot
proteins
pubmed
2332434
uniprot
proteins
pubmed
23847195
uniprot
proteins
pubmed
2676155
uniprot
proteins
pubmed
27663661
uniprot
proteins
pubmed
32839608
uniprot
proteins
pubmed
3379044
uniprot
proteins
sequence_length
406
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:P11279}; Single-pass type I membrane protein {ECO:0000255}. Endosome membrane {ECO:0000250|UniProtKB:P11279}; Single-pass type I membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000250|UniProtKB:P11279}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:23847195}; Single-pass type I membrane protein {ECO:0000255}. Cytolytic granule membrane {ECO:0000305|PubMed:32839608}; Single-pass type I membrane protein {ECO:0000255}. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane (By similarity). Colocalizes with OSBPL1A at the late endosome (By similarity). {ECO:0000250|UniProtKB:P05300, ECO:0000250|UniProtKB:P11279}.
uniprot
proteins
transmembrane_region
TRANSMEM 371..394; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00740
uniprot
proteins