FBXO42
entrez
54455
canonical
uniprot
Q6P3S6
canonical
ensembl
ENSG00000037637
resolver
ensembl
ENSG00000291375
resolver
ensp
ENSP00000364742
resolver
ensp
ENSP00000516839
resolver
ensp
ENSP00000538645
resolver
ensp
ENSP00000538646
resolver
ensp
ENSP00000538647
resolver
ensp
ENSP00000538648
resolver
ensp
ENSP00000538649
resolver
ensp
ENSP00000538652
resolver
ensp
ENSP00000538653
resolver
ensp
ENSP00000627298
resolver
ensp
ENSP00000627300
resolver
ensp
ENSP00000627301
resolver
ensp
ENSP00000627302
resolver
ensp
ENSP00000627303
resolver
ensp
ENSP00000678001
resolver
enst
ENST00000375592
resolver
enst
ENST00000707355
resolver
enst
ENST00000868586
resolver
enst
ENST00000868587
resolver
enst
ENST00000868588
resolver
enst
ENST00000868589
resolver
enst
ENST00000868590
resolver
enst
ENST00000868593
resolver
enst
ENST00000868594
resolver
enst
ENST00000957239
resolver
enst
ENST00000957241
resolver
enst
ENST00000957242
resolver
enst
ENST00000957243
resolver
enst
ENST00000957244
resolver
genesymbol
FBXO42
resolver
genesymbol_syn
FBX42
resolver
genesymbol_syn
JFK
resolver
genesymbol_syn
KIAA1332
resolver
hgnc
HGNC:29249
resolver
uniprot
B3KP30
resolver
uniprot
Q5TEU8
resolver
uniprot
Q86XI0
resolver
uniprot
Q8N3N4
resolver
uniprot
Q8N5F8
resolver
uniprot
Q9BRM0
resolver
uniprot
Q9P2L4
resolver
uniprot_entry
FBX42_HUMAN
resolver
uniprot_sec
B3KP30
resolver
uniprot_sec
Q5TEU8
resolver
uniprot_sec
Q86XI0
resolver
uniprot_sec
Q8N3N4
resolver
uniprot_sec
Q8N5F8
resolver
uniprot_sec
Q9BRM0
resolver
uniprot_sec
Q9P2L4
resolver
amino_acid_sequence
MASSSDSEDDSFMAVDQEETVLEGTMDQDEEPHPVLEAEETRHNRSMSELPEEVLEYILSFLSPYQEHKTAALVCKQWYRLIKGVAHQCYHGFMKAVQEGNIQWESRTYPYPGTPITQRFSHSACYYDANQSMYVFGGCTQSSCNAAFNDLWRLDLNSKEWIRPLASGSYPSPKAGATLVVYKDLLVLFGGWTRPSPYPLHQPERFFDEIHTYSPSKNWWNCIVTTHGPPPMAGHSSCVIDDKMIVFGGSLGSRQMSNDVWVLDLEQWAWSKPNISGPSPHPRGGQSQIVIDDATILILGGCGGPNALFKDAWLLHMHSGPWAWQPLKVENEEHGAPELWCHPACRVGQCVVVFSQAPSGRAPLSPSLNSRPSPISATPPALVPETREYRSQSPVRSMDEAPCVNGRWGTLRPRAQRQTPSGSREGSLSPARGDGSPILNGGSLSPGTAAVGGSSLDSPVQAISPSTPSAPEGYDLKIGLSLAPRRGSLPDQKDLRLGSIDLNWDLKPASSSNPMDGMDNRTVGGSMRHPPEQTNGVHTPPHVASALAGAVSPGALRRSLEAIKAMSSKGPSASAALSPPLGSSPGSPGSQSLSSGETVPIPRPGPAQGDGHSLPPIARRLGHHPPQSLNVGKPLYQSMNCKPMQMYVLDIKDTKEKGRVKWKVFNSSSVVGPPETSLHTVVQGRGELIIFGGLMDKKQNVKYYPKTNALYFVRAKR
uniprot
proteins
function
FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for bipolar spindle formation during mitosis (PubMed:33539788). Recognizes p53/TP53 phosphorylated by CSN-associated kinase, promoting its polyubiquitination and proteasomal degradation (PubMed:19509332, PubMed:21127074, PubMed:39134694). Positively regulates the Notch signaling pathway through 'Lys-63'-linked polyubiquitination of the transcriptional effector RBPJ, stabilizing its chromatin association and potentiating transcriptional activation of Notch target genes (PubMed:36129980). Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of components of the PP4 phosphatase complex, including PP4C, PP4R2, PP4R3A and PP4R3B, thereby restraining PP4 phosphatase activity and ensuring proper DNA damage response signaling (PubMed:41484364). Collaborates with CCDC6 to promote polyubiquitination and proteasomal degradation of the catalytic subunit PP2AC (PubMed:41986709). Recognizes ACAA2, promoting its ubiquitination and proteasomal degradation in hepatocytes, thereby attenuating fatty acid beta-oxidation; this activity is negatively regulated by CAND1, which prevents assembly of the SCF(FBXO42)-ACAA2 degradation complex (By similarity). {ECO:0000250|UniProtKB:Q6PDJ6, ECO:0000269|PubMed:19509332, ECO:0000269|PubMed:21127074, ECO:0000269|PubMed:33539788, ECO:0000269|PubMed:36129980, ECO:0000269|PubMed:39134694, ECO:0000269|PubMed:41484364, ECO:0000269|PubMed:41986709}.
uniprot
proteins
mass_dalton
77839
uniprot
proteins
pubmed
10718198
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19509332
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21127074
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
33539788
uniprot
proteins
pubmed
36129980
uniprot
proteins
pubmed
39134694
uniprot
proteins
pubmed
41484364
uniprot
proteins
pubmed
41986709
uniprot
proteins
sequence_length
717
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:39134694}.
uniprot
proteins