Loxl1
entrez
16949
canonical
uniprot
P97873
canonical
ensembl
ENSMUSG00000032334
resolver
ensp
ENSMUSP00000057406
resolver
enst
ENSMUST00000061799
resolver
genesymbol
Loxl1
resolver
genesymbol_syn
Lox2
resolver
genesymbol_syn
Loxl
resolver
uniprot
A0A0R4J0Q4
resolver
uniprot
Q91ZY4
resolver
uniprot
Q99KX3
resolver
uniprot_entry
A0A0R4J0Q4_MOUSE
resolver
uniprot_entry
LOXL1_MOUSE
resolver
uniprot_sec
Q91ZY4
resolver
uniprot_sec
Q99KX3
resolver
amino_acid_sequence
MALAGAGSQLRTLVWSACLCVLVHGQQAQPGQGSDPGRWRQLIQWENNGQVYSLLNSGSEYVPAGPQRGETSSRVLLAGAPQTSQRRSQGGPRRRQAPSLPLPGRVGSDTVRGQTRHPFGFGQVPDNWREVAVGDSTGMARARTSVSQQRHGGSASSSVSASAFATTYRQPSPYPQQFPYPQAPFVNQYENYDPASRTYEQGYVYYRGAGGGMGAGAAAVASAGVIYPFQPRARYEDYGGGGGEEQPEYPAQGFYPAPERPYVPQPQPQPQPQPQPQPQPSDGLDRRYSHSLYNEGTPGFEQAYPDPSTDVSQAPAGAGGTYGGAGDPRLGWYPPYAANVPPEAYVPPRAVEPQPPFRVLEPPYLPVRSSDAPSQGGERNGAQQGRLSVGSVYRPNQNGRGLPDLVPDPNYVQASTYVQRAHLYSLRCAAEEKCLASTAYAPEATDYDLRVLLRFPQRVKNQGTADFLPNRPRHTWEWHSCHQHYHSMDEFSHYDLLDASTGKKVAEGHKASFCLEDSTCDFGNLKRYACTSHTQGLSPGCYDTYNADIDCQWIDITDVQPGNYILKVHVNPKYIVLESDFTNNVVRCNIHYTGRYVSTTNCKIVQS
uniprot
proteins
ec_number
1.4.3.13
uniprot
proteins
function
FUNCTION: Catalyzes the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin, resulting in the formation of covalent cross-linkages, and the stabilization of collagen and elastin fibers (PubMed:14745449). Essential for the elastic fiber homeostasis and for their maintenance at adult age (PubMed:14745449). {ECO:0000269|PubMed:14745449}.
uniprot
proteins
mass_dalton
66506
uniprot
proteins
post_translational_modification
PTM: The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. {ECO:0000250|UniProtKB:P33072}.; PTM: Proteolytic processing by a furin-like protease causes removal of N-terminal propeptide resulting in an enzyme largely inactive, but further proteolytic processing by BMP1 results in enzyme activation. {ECO:0000250|UniProtKB:Q95L39}.
uniprot
proteins
protein_family
Lysyl oxidase family
uniprot
proteins
pubmed
14745449
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9119402
uniprot
proteins
pubmed
9250877
uniprot
proteins
sequence_length
607
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000269|PubMed:14745449}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:14745449}.
uniprot
proteins