Trabd2b
entrez
666048
canonical
uniprot
B1ATG9
canonical
ensembl
ENSMUSG00000070867
resolver
ensp
ENSMUSP00000092494
resolver
enst
ENSMUST00000094894
resolver
genesymbol
Trabd2b
resolver
genesymbol_syn
Gm12824
resolver
genesymbol_syn
Hkat
resolver
genesymbol_syn
Tiki2
resolver
uniprot_entry
TIKI2_MOUSE
resolver
amino_acid_sequence
MHAALAGPLLAALLATARARPQPPDGGQCRPPGSQRDLNSFLWTIRRHPPAYLFGTIHVPYTRVWDFIPDNSKAAFQASTHVYFELDLTDPYTISALASCQLLPHGENLQDVLPRELYWRLKRHLDYVKLMIPSWMTPAQRGKGLYADYLFNAIAGNWERKRPVWVMLMVNSLTETDVRSRGVPVLDLYLAQQAEKMKKSTGAVERVEEQCHPLNGLNFSQVLFALNQTLLQHESVRAGSLQAPYTTEDLIKHYNCGDLNAVIFNHDTSQLPNFINTTLPPHEQVTAQEIDSYFRQELIYKRNERMGKRVMALLQENQDKICFFAFGAGHFLGNNTVIDVLRQAGLEVDHTPAGQAIHGPAAVGSPAPPPEITSPASPAPATPAAAVPEATSATPTTPPEEEDPVLSPHLLLPDSLSQLEEFGRQKWRKRLNKHQRPRQFNDLWVRIEDSTTISPPPLPLQPTPSSETTKPFVKSSHQLQQQDAVGPTSSSAPTLGLLHAITASIVAPFLLHSLGPS
uniprot
proteins
ec_number
3.4.-.-
uniprot
proteins
function
FUNCTION: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. {ECO:0000250|UniProtKB:A6NFA1}.
uniprot
proteins
mass_dalton
57368
uniprot
proteins
post_translational_modification
PTM: Attached to the external leaflet of the plasma membrane and enriched in membrane rafts via a GPI anchor. The GPI anchor can be cleaved by GDPD4/GDE6 and GDPD2/GDE3, releasing the protein from membranes. {ECO:0000250|UniProtKB:A6NFA1}.
uniprot
proteins
protein_family
TIKI family
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23152936
uniprot
proteins
sequence_length
517
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23152936}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:A6NFA1}. Membrane raft {ECO:0000250|UniProtKB:A6NFA1}.
uniprot
proteins