Rin1
entrez
207119
canonical
uniprot
P97680
canonical
ensembl
ENSRNOG00000050223
resolver
ensp
ENSRNOP00000066064
resolver
enst
ENSRNOT00000072261
resolver
genesymbol
Rin1
resolver
uniprot
M0R999
resolver
uniprot_entry
M0R999_RAT
resolver
uniprot_entry
RIN1_RAT
resolver
amino_acid_sequence
MEDPGETEAHPLGATSLNFVPGYQQEEKPSPDPLYDTPDARGVQAGGSQQPARTVSLRERLLITRPVWLQLRANAAAALHVLRTEPPGTFLVRKSNTRQCQTLCVRLPEASGPSFVSSHYLQESPGGISLEGSELTFPDLVQLICAYCHTRDILLLPLPLPRAIHQAATHKELEAISHLGMEFWSSSLNTKNQQRPSEAPQIPRLKARSPQELDQGTGAALCFFNPLFPGDLGPTKREKFKRSFKVRVSTETSSPLSPPAVPPPPVPVLPGTSSSQTERLPPRQLLQRESSVGYRVPGSASGPSLPPLPSLQEVDCCSPSSSEEEGSSGSPTTSPRLSRPRHRRPLLRSMSSAFCSLLAPERQVGRAATMLMQNRYTAVGQLVQDLLTQVRVGPESRELQGIRQALSRARAMLSAELGPEKLLPPERLELVLEKSLHRSVLKPLRPILAARLRRRLSTDGSLGRLAEGFRLARTQGPGAFGSHLNLSSPVEIEPVRQKLLQLLRAYSPSAQIKWLLQACKLLYTALKTQAGENAGADEFLPLLSLVLAQCDLPDLLLEAEYMSELLEPTLLTGEGGYYLTSLSASLALLSGLSQAHALPLSPAQELQRSLALWEQRRLPATHNFQHLLRVAYQDPSTGCTSKTLAVPPGSSIATLSQLCATKFRVTQPDAFGLFLYKDQGYHRLPPEALVHRLPTTGYLIYRRAERPETQRAATEKTKTGNERPERGAWEEEKGGLNGEGKSEIAVDQEGKDQARGGHMQLEEQKAEGCPALEE
uniprot
proteins
function
FUNCTION: Ras effector protein, which may serve as an inhibitory modulator of neuronal plasticity in aversive memory formation. Can affect Ras signaling at different levels. First, by competing with RAF1 protein for binding to activated Ras. Second, by enhancing signaling from ABL1 and ABL2, which regulate cytoskeletal remodeling. Third, by activating RAB5A, possibly by functioning as a guanine nucleotide exchange factor (GEF) for RAB5A, by exchanging bound GDP for free GTP, and facilitating Ras-activated receptor endocytosis (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
84727
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues by ABL1 and ABL2. Phosphorylation at Ser-351 by PRKD1 induces interaction with 14-3-3 proteins (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
RIN (Ras interaction/interference) family
uniprot
proteins
pubmed
9144171
uniprot
proteins
sequence_length
774
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Some amount is membrane-associated. {ECO:0000250}.
uniprot
proteins