Lurap1
entrez
68075
canonical
uniprot
Q9D6I9
canonical
ensembl
ENSMUSG00000028701
resolver
ensp
ENSMUSP00000030469
resolver
enst
ENSMUST00000030469
resolver
genesymbol
Lurap1
resolver
genesymbol_syn
1520402A15Rik
resolver
genesymbol_syn
Lrap35a
resolver
genesymbol_syn
Lrp35a
resolver
uniprot
A2A8F6
resolver
uniprot_entry
A2A8F6_MOUSE
resolver
uniprot_entry
LURA1_MOUSE
resolver
amino_acid_sequence
MEGTAESQTPDLRDVEGKVGRKIPEGLLRGLRGECELGTSGDVLLPGAPSTGHGLGDKIMALRMELAYLRAIDVKILQQLVTLNEGIEAVRWLLEERGTLTSHCSSLTSSQYSLTGGSPGRSRRGSWDSLPDTSSTDRLDSVSIGSFLDTVTPRELDEQGLPGPSCPEIDWAKVIPTEDRARTEVDMTSTKLGSLTATWKLPGDGLQCGPPEPSEDGNANQGFEAHWYWGQCQDDVTFL
uniprot
proteins
function
FUNCTION: Acts as an activator of the canonical NF-kappa-B pathway and drive the production of pro-inflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway. In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella (By similarity). {ECO:0000250|UniProtKB:D4A8G3}.
uniprot
proteins
mass_dalton
25830
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250|UniProtKB:D4A8G3}.
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
239
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96LR2}.
uniprot
proteins