Npsr1
entrez
319239
canonical
uniprot
Q8BZP8
canonical
ensembl
ENSMUSG00000043659
resolver
ensp
ENSMUSP00000056432
resolver
ensp
ENSMUSP00000115126
resolver
ensp
ENSMUSP00000317630
resolver
enst
ENSMUST00000059650
resolver
genesymbol
Npsr1
resolver
genesymbol_syn
Gpr154
resolver
genesymbol_syn
Pgr14
resolver
uniprot
A1KXK3
resolver
uniprot
Q80T64
resolver
uniprot
Q8BYA1
resolver
uniprot_entry
A1KXK3_MOUSE
resolver
uniprot_entry
NPSR1_MOUSE
resolver
uniprot_sec
Q80T64
resolver
uniprot_sec
Q8BYA1
resolver
amino_acid_sequence
MPANLTEGSFHANQTVPMLDSSPVACTEIVTFTEALVAEEWGSFYSSFKTEQLITLWVLFVVTIVGNSVVLFSTCRRKRKSRMTFFVTQLAITDSFTGLINILTDIIWRFTGDFMAPDLVCRVVRYLQVVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEKQAKVLIGIAWSLSFLFSIPTLIIFGKRTLSNGEVQCWALWPDDSYWTPYMTIVAFLVYFIPLAIISVIYGLVIRTIWMKSKTHETVISNCSDGKLCCSYNRGLISKAKIKAIKYSIVIILAFICCWSPYFLFDILDNFNVLPDTKERFYASVIIQNLPALNSAINPLIYCIFSSSICSPCKMQRSQDSRMTYRERSERHEMQILSKPEFI
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for neuropeptide S (NPS) (PubMed:31619542). Receptor activation by NPS initiates a G(q)/GNAQ-dependent phospholipase C-activating signaling pathway, resulting in Ca(2+) mobilization from intracellular stores and increased intracellular Ca(2+) levels. In addition to this pathway, NPS binding to its receptor activates cAMP/PKA signal transduction. Finally, both pathways converge to activate ERK1/ERK2 phosphorylation and signaling cascade. Inhibits cell growth in response to NPS binding. {ECO:0000250|UniProtKB:Q6W5P4, ECO:0000269|PubMed:31619542}.
uniprot
proteins
mass_dalton
42439
uniprot
proteins
mutagenesis
MUTAGEN 206; /note="Y->H: Muant mice show reduced sleep time and their contextual memory is more resilient to sleep loss than in wild-type animals. Increased function in neuropeptide signaling pathway."; /evidence="ECO:0000269|PubMed:31619542
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Vasopressin/oxytocin receptor subfamily
uniprot
proteins
pubmed
12679517
uniprot
proteins
pubmed
15073379
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
31619542
uniprot
proteins
sequence_length
371
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6W5P4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q6W5P4}.
uniprot
proteins
transmembrane_region
TRANSMEM 53..73; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 83..103; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 124..144; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 165..185; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 213..233; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 276..296; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 313..333; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins