BPHL
entrez
670
canonical
uniprot
Q86WA6
canonical
ensembl
ENSG00000137274
resolver
ensp
ENSP00000369726
resolver
ensp
ENSP00000369739
resolver
ensp
ENSP00000390472
resolver
ensp
ENSP00000787431
resolver
enst
ENST00000380368
resolver
genesymbol
BPHL
resolver
genesymbol_syn
MCNAA
resolver
hgnc
HGNC:1094
resolver
uniprot
F6VCN3
resolver
uniprot
Q00306
resolver
uniprot
Q13855
resolver
uniprot
Q3KP51
resolver
uniprot
Q49AI2
resolver
uniprot_entry
BPHL_HUMAN
resolver
uniprot_entry
F6VCN3_HUMAN
resolver
uniprot_entry
Q49AI2_HUMAN
resolver
uniprot_sec
Q00306
resolver
uniprot_sec
Q13855
resolver
uniprot_sec
Q3KP51
resolver
amino_acid_sequence
MVAVLGGRGVLRLRLLLSALKPGIHVPRAGPAAAFGTSVTSAKVAVNGVQLHYQQTGEGDHAVLLLPGMLGSGETDFGPQLKNLNKKLFTVVAWDPRGYGHSRPPDRDFPADFFERDAKDAVDLMKALKFKKVSLLGWSDGGITALIAAAKYPSYIHKMVIWGANAYVTDEDSMIYEGIRDVSKWSERTRKPLEALYGYDYFARTCEKWVDGIRQFKHLPDGNICRHLLPRVQCPALIVHGEKDPLVPRFHADFIHKHVKGSRLHLMPEGKHNLHLRFADEFNKLAEDFLQ
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: Specific alpha-amino acid ester serine hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol (PubMed:12732646, PubMed:15832508, PubMed:18256025, PubMed:25333274, PubMed:32196348). Has homocysteine-thiolactonase activity (in vitro) and may play a significant role in the detoxification of homocysteine thiolactone in vivo (PubMed:25333274). Catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir, converting them into their active forms (acyclovir and ganciclovir) (PubMed:15832508, PubMed:18256025). {ECO:0000269|PubMed:12732646, ECO:0000269|PubMed:15832508, ECO:0000269|PubMed:18256025, ECO:0000269|PubMed:25333274, ECO:0000269|PubMed:32196348}.
uniprot
proteins
mass_dalton
32543
uniprot
proteins
mutagenesis
MUTAGEN 139; /note="S->A: <0.1% of wild type valacyclovir hydrolase activity."; /evidence="ECO:0000269|PubMed:18256025"; MUTAGEN 244; /note="D->N: <0.1% of wild type valacyclovir hydrolase activity."; /evidence="ECO:0000269|PubMed:18256025"; MUTAGEN 272; /note="H->A: Complete loss of valacyclovir hydrolase activity."; /evidence="ECO:0000269|PubMed:18256025
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
protein_family
Lipase family
uniprot
proteins
pubmed
12732646
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15832508
uniprot
proteins
pubmed
18256025
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2393862
uniprot
proteins
pubmed
25333274
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
32196348
uniprot
proteins
pubmed
34800366
uniprot
proteins
pubmed
7759552
uniprot
proteins
pubmed
9721218
uniprot
proteins
sequence_length
291
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:34800366}.
uniprot
proteins