Mcm2
entrez
17216
canonical
uniprot
P97310
canonical
ensembl
ENSMUSG00000002870
resolver
ensp
ENSMUSP00000061923
resolver
enst
ENSMUST00000058011
resolver
genesymbol
Mcm2
resolver
genesymbol_syn
Bm28
resolver
genesymbol_syn
Cdcl1
resolver
genesymbol_syn
Kiaa0030
resolver
genesymbol_syn
Mcmd2
resolver
uniprot
O08971
resolver
uniprot
O89057
resolver
uniprot
Q8C2R0
resolver
uniprot_entry
MCM2_MOUSE
resolver
uniprot_sec
O08971
resolver
uniprot_sec
O89057
resolver
uniprot_sec
Q8C2R0
resolver
amino_acid_sequence
MAESSESLSASSPARQRRRISDPLTSSPGRSSRRADALTSSPGRDLPPFEDESEGLLGTEGPMEEEEDGEELIGDGMERDYRPIPELDVYEAEGLALDDEDVEELTASQREAAERTMRQRDREAGRGLGRMRRGLLYDSSEEDEERPARKRRHVERATEDGEEDEEMIESIENLEDLKGHSVREWVSMAGPRLEIHHRFKNFLRTHVDSHGHNVFKERISDMCKENRESLVVNYEDLAAREHVLAYFLPEAPAELLQIFDEAALEVVLAMYPKYDRITNHIHVRISHLPLVEELRSLRQLHLNQLIRTSGVVTSCTGVLPQLSMVKYNCSKCNFVLGPFCQSQNQEVKPGSCPECQSAGPFEINMEETIYQNYQRIRIQESPGKVAAGRLPRSKDAILLADLVDSCKPGDEIELTGIYHNNYDGSLNTANGFPVFATIILANHVAKKDNKVAVGELTDEDVKMITGLSKDQQIGEKIFASIAPSIYGHEDIKRGLALALFGGEPKNPGGKHKVRGDINVLLCGDPGTAKSQFLKYIEKVSSRAIFTTGQGASAVGLTAYVQRHPVSREWTLEAGALVLADRGVCLIDEFDKMNDQDRTSIHEAMEQQSISISKAGIVTSLQARCTVIAAANPIGGRYDPSLTFSENVDLTEPIISRFDVLCVVRDTVDPVQDEMLARFVVGSHVRHHPSNKKDEGLTNGGTLEPAMPNTYGVEPLPQEVLKKYIIYAKERVRPKLNQMDQDKVARMYSDLRKESMATGSIPITVRHIESMIRMAEAHARMHLRDYVMEDDVNMAIRVMMESFIDTQKFSVMRSMRKTFARYLSFRRDNNDLLLFILKQLVAEQVTYQRNRFGAQQDTIEIPEKDLMDKARQINIHNLSAFYDSDLFKFNKFSRDLKRKLILQQF
uniprot
proteins
ec_number
3.6.4.12
uniprot
proteins
function
FUNCTION: Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. Required for the entry in S phase and for cell division (PubMed:10567526). Plays a role in terminally differentiated hair cells development of the cochlea and induces cells apoptosis (By similarity). {ECO:0000250|UniProtKB:P49736, ECO:0000269|PubMed:10567526}.
uniprot
proteins
mass_dalton
102078
uniprot
proteins
mutagenesis
MUTAGEN 237; /note="L->P: Impairs interaction with KAT7."; /evidence="ECO:0000269|PubMed:11278932
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser-108 by ATR in proliferating cells. Ser-108 proliferation is increased by genotoxic agents. Ser-40 is mediated by the CDC7-DBF4 and CDC7-DBF4B complexes, while Ser-53 phosphorylation is only mediated by the CDC7-DBF4 complex. Phosphorylation by the CDC7-DBF4 complex during G1/S phase is required for the initiation of DNA replication (By similarity). {ECO:0000250|UniProtKB:P49736}.; PTM: Acetylated by MCM3AP. {ECO:0000250|UniProtKB:P25205}.; PTM: O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner. {ECO:0000250|UniProtKB:P25205}.
uniprot
proteins
protein_family
MCM family
uniprot
proteins
pubmed
10517317
uniprot
proteins
pubmed
10567526
uniprot
proteins
pubmed
11278932
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17622165
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
36807739
uniprot
proteins
pubmed
9077461
uniprot
proteins
pubmed
9371513
uniprot
proteins
pubmed
9798653
uniprot
proteins
sequence_length
904
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P49736}. Chromosome {ECO:0000250|UniProtKB:P49736}. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. {ECO:0000250|UniProtKB:P55861}.
uniprot
proteins