MAP2K7
entrez
5609
canonical
uniprot
O14733
canonical
ensembl
ENSG00000076984
resolver
ensp
ENSP00000381066
resolver
ensp
ENSP00000381068
resolver
ensp
ENSP00000381070
resolver
ensp
ENSP00000553479
resolver
genesymbol
MAP2K7
resolver
genesymbol_syn
JNKK2
resolver
genesymbol_syn
MEK7
resolver
genesymbol_syn
MKK7
resolver
genesymbol_syn
PRKMK7
resolver
genesymbol_syn
SKK4
resolver
hgnc
HGNC:6847
resolver
uniprot
B2R9S5
resolver
uniprot
B4DV95
resolver
uniprot
D6W659
resolver
uniprot
O14648
resolver
uniprot
O14816
resolver
uniprot
O60452
resolver
uniprot
O60453
resolver
uniprot
Q1PG43
resolver
uniprot
Q8IY10
resolver
uniprot_entry
B4DV95_HUMAN
resolver
uniprot_entry
MP2K7_HUMAN
resolver
uniprot_sec
B2R9S5
resolver
uniprot_sec
D6W659
resolver
uniprot_sec
O14648
resolver
uniprot_sec
O14816
resolver
uniprot_sec
O60452
resolver
uniprot_sec
O60453
resolver
uniprot_sec
Q1PG43
resolver
uniprot_sec
Q8IY10
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation by specific MAP kinase kinase kinases such as MAP3K1/MEKK1, MAP3K3/MEKK3, MAP3K11/MLK3 and MAP3K12/DLK. {ECO:0000269|PubMed:16442502, ECO:0000269|PubMed:9312068}.
uniprot
proteins
amino_acid_sequence
MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
uniprot
proteins
ec_number
2.7.12.2
uniprot
proteins
function
FUNCTION: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by pro-inflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Part of a non-canonical MAPK signaling pathway, composed of the upstream MAP3K12 kinase and downstream MAP kinases MAPK1/ERK2 and MAPK3/ERK1, that enhances the AP-1-mediated transcription of APP in response to APOE (PubMed:28111074). {ECO:0000269|PubMed:28111074, ECO:0000269|PubMed:9312068, ECO:0000269|PubMed:9372971, ECO:0000269|PubMed:9535930, ECO:0000269|Ref.5}.
uniprot
proteins
mass_dalton
47485
uniprot
proteins
post_translational_modification
PTM: Activated by phosphorylation on Ser-271 and Thr-275 by MAP kinase kinase kinases (MAP3Ks). {ECO:0000250}.
uniprot
proteins
protein_family
MAP kinase kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
pubmed
10490659
uniprot
proteins
pubmed
11104681
uniprot
proteins
pubmed
12189133
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15866172
uniprot
proteins
pubmed
16442502
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17496909
uniprot
proteins
pubmed
18286207
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20801953
uniprot
proteins
pubmed
21278800
uniprot
proteins
pubmed
21333379
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28111074
uniprot
proteins
pubmed
9207092
uniprot
proteins
pubmed
9312068
uniprot
proteins
pubmed
9372971
uniprot
proteins
pubmed
9535930
uniprot
proteins
sequence_length
419
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm {ECO:0000250}.
uniprot
proteins