Igf2bp2
entrez
319765
canonical
uniprot
Q5SF07
canonical
ensembl
ENSMUSG00000033581
resolver
ensp
ENSMUSP00000097629
resolver
genesymbol
Igf2bp2
resolver
genesymbol_syn
Imp2
resolver
genesymbol_syn
Vickz2
resolver
uniprot
A6X8Z4
resolver
uniprot
Q3TCU4
resolver
uniprot
Q7TQF9
resolver
uniprot_entry
IF2B2_MOUSE
resolver
uniprot_sec
A6X8Z4
resolver
uniprot_sec
Q3TCU4
resolver
uniprot_sec
Q7TQF9
resolver
amino_acid_sequence
MMNKLYIGNLSPAVTADDLRQLFGDRKLPLAGQVLLKSGYAFVDYPDQNWAIRAIETLSGKVELHGKIMEVDYSVSKKLRSRRIQIRNIPPHLQWEVLDGLLAEYGTVENVEQVNTDTETAVVNVTYMTREEAKLAIEKLSGHQFEDYSFKISYIPDEEVSSPSPPHRAREQGHGPGSSSQARQIDFPLRILVPTQFVGAIIGKEGLTIKNITKQTQSRVDIHRKENSGAAEKPVTIHATPEGTSEACRMILEIMQKEADETKLAEEVPLKILAHNGFVGRLIGKEGRNLKKIEHETGTKITISSLQDLSIYNPERTITVRGTIEACANAEIEIMKKLREAFENDMLAVNQQANLIPGLNLSALGIFSTGLSVLPPPAGPRGVPPSPPYHPFATHSGYFSSLYPHHHFGPFPHHHSYPEQETVSLFIPTQAVGAIIGKKGAHIKQLARFAGASIKIAPAEGPDVSERMVIITGPPEAQFKAQGRIFGKLKEENFFNPKEEVKLEAHIRVPSSTAGRVIGKGGKTVNELQNLTSAEVIVPRDQTPDENEEVIVRIIGHFFASQTAQRKIREIVQQVKQQEQRYPQGVAPQRSK
uniprot
proteins
function
FUNCTION: RNA-binding factor that recruits target transcripts to cytoplasmic protein-RNA complexes (mRNPs). This transcript 'caging' into mRNPs allows mRNA transport and transient storage. It also modulates the rate and location at which target transcripts encounter the translational apparatus and shields them from endonuclease attacks or microRNA-mediated degradation (By similarity). Preferentially binds to N6-methyladenosine (m6A)-containing mRNAs and increases their stability (By similarity). Binds to the 5'-UTR of the insulin-like growth factor 2 (IGF2) mRNAs. Binding is isoform-specific. Binds to beta-actin/ACTB and MYC transcripts (By similarity). Increases MYC mRNA stability by binding to the coding region instability determinant (CRD) and binding is enhanced by m6A-modification of the CRD (By similarity). {ECO:0000250|UniProtKB:Q9Y6M1}.
uniprot
proteins
mass_dalton
65584
uniprot
proteins
protein_family
RRM IMP/VICKZ family
uniprot
proteins
pubmed
10875929
uniprot
proteins
pubmed
15225648
uniprot
proteins
pubmed
15601260
uniprot
proteins
pubmed
16049158
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
592
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasm, P-body {ECO:0000250|UniProtKB:Q9Y6M1}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:Q9Y6M1}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Localizes at the connecting piece and the tail of the spermatozoa. In response to cellular stress, such as oxidative stress, recruited to stress granules (By similarity). {ECO:0000250}.
uniprot
proteins