SLC9A8
entrez
23315
canonical
uniprot
Q9Y2E8
canonical
ensembl
ENSG00000197818
resolver
ensp
ENSP00000354966
resolver
ensp
ENSP00000416418
resolver
ensp
ENSP00000521428
resolver
ensp
ENSP00000521430
resolver
genesymbol
SLC9A8
resolver
genesymbol_syn
KIAA0939
resolver
genesymbol_syn
NHE8
resolver
hgnc
HGNC:20728
resolver
uniprot
B4DIX7
resolver
uniprot
B4DTQ8
resolver
uniprot
Q2M1U9
resolver
uniprot
Q68CZ8
resolver
uniprot
Q9BX15
resolver
uniprot
Q9Y507
resolver
uniprot_entry
B4DIX7_HUMAN
resolver
uniprot_entry
SL9A8_HUMAN
resolver
uniprot_sec
B4DTQ8
resolver
uniprot_sec
Q2M1U9
resolver
uniprot_sec
Q68CZ8
resolver
uniprot_sec
Q9BX15
resolver
uniprot_sec
Q9Y507
resolver
activity_regulation
ACTIVITY REGULATION: HOE642 inhibits SLC9A8 activity. {ECO:0000269|PubMed:34288721}.
uniprot
proteins
amino_acid_sequence
MGEKMAEEERFPNTTHEGFNVTLHTTLVVTTKLVLPTPGKPILPVQTGEQAQQEEQSSGMTIFFSLLVLAICIILVHLLIRYRLHFLPESVAVVSLGILMGAVIKIIEFKKLANWKEEEMFRPNMFFLLLLPPIIFESGYSLHKGNFFQNIGSITLFAVFGTAISAFVVGGGIYFLGQADVISKLNMTDSFAFGSLISAVDPVATIAIFNALHVDPVLNMLVFGESILNDAVSIVLTNTAEGLTRKNMSDVSGWQTFLQALDYFLKMFFGSAALGTLTGLISALVLKHIDLRKTPSLEFGMMIIFAYLPYGLAEGISLSGIMAILFSGIVMSHYTHHNLSPVTQILMQQTLRTVAFLCETCVFAFLGLSIFSFPHKFEISFVIWCIVLVLFGRAVNIFPLSYLLNFFRDHKITPKMMFIMWFSGLRGAIPYALSLHLDLEPMEKRQLIGTTTIVIVLFTILLLGGSTMPLIRLMDIEDAKAHRRNKKDVNLSKTEKMGNTVESEHLSELTEEEYEAHYIRRQDLKGFVWLDAKYLNPFFTRRLTQEDLHHGRIQMKTLTNKWYEEVRQGPSGSEDDEQELL
uniprot
proteins
function
FUNCTION: Na(+)/H(+) antiporter. Mediates the electoneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (PubMed:15522866). Acts as an Na(+)/H(+) exchanger in the trans-Golgi. Contributes to the regulation of pH regulation of Golgi apparatus, and consequently, in protein trafficking and endosomal morphology (PubMed:15522866, PubMed:20719963). In germ cells, plays a crucial role in acrosome biogenesis and sperm development, probably by playing a role in the fusion of the Golgi-derived vesicles that form the acrosomal cap (By similarity). Can also be active at the cell surface of specialized cells. In the small intestine, at the cell membrane, plays a major physiological role in transepithelial absorption of Na(+) and regulates intracellular pH homeostasis of intestinal epithelial cells (PubMed:34288721). Acts as an important regulator of mucosal integrity in the intestine and in the stomach, could mediate the pH fluctuation necessary for mucin exocytosis or assist membrane trafficking of other proteins (By similarity). Plays a role in photoreceptor survival and in the maintenance of intracellular pH homeostasis in retinal pigment epithelium (RPE cells) (By similarity). {ECO:0000250|UniProtKB:Q8R4D1, ECO:0000269|PubMed:15522866, ECO:0000269|PubMed:20719963, ECO:0000269|PubMed:34288721}.
uniprot
proteins
mass_dalton
65422
uniprot
proteins
mutagenesis
MUTAGEN 225; /note="E->Q: Induces endosomal clustering."; /evidence="ECO:0000269|PubMed:20719963
uniprot
proteins
protein_family
Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
uniprot
proteins
pubmed
10231032
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15522866
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18209477
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20719963
uniprot
proteins
pubmed
34288721
uniprot
proteins
sequence_length
581
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:15522866}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:15522866, ECO:0000269|PubMed:20719963}; Multi-pass membrane protein {ECO:0000255}. Endosome, multivesicular body membrane {ECO:0000269|PubMed:20719963}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:34288721}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q8R4D1}. Note=Intracellular versus plasma membrane-resident location may vary with cell type. Mainly localized to the mid- to trans-Golgi compartments but a proportion is also localized to multivesicular bodies (PubMed:15522866, PubMed:20719963). Localized at the apical membrane of polarized gastrointestinal epithelial cells (By similarity). Recruitment to the plasma membrane upon acid stimulation (By similarity). {ECO:0000250|UniProtKB:Q4L208, ECO:0000269|PubMed:15522866, ECO:0000269|PubMed:20719963}.
uniprot
proteins
transmembrane_region
TRANSMEM 60..80; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 84..104; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 123..143; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 156..176; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 191..211; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 264..284; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 311..331; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 354..374; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 379..399; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 417..437; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 451..471; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins