OSBPL5
entrez
114879
canonical
uniprot
Q9H0X9
canonical
ensembl
ENSG00000021762
resolver
ensp
ENSP00000263650
resolver
ensp
ENSP00000302872
resolver
ensp
ENSP00000374639
resolver
ensp
ENSP00000635731
resolver
genesymbol
OSBPL5
resolver
genesymbol_syn
KIAA1534
resolver
genesymbol_syn
OBPH1
resolver
genesymbol_syn
ORP5
resolver
hgnc
HGNC:16392
resolver
uniprot
A6NDP0
resolver
uniprot
A6NJS8
resolver
uniprot
A8KAD5
resolver
uniprot
B4DVB0
resolver
uniprot
Q54A90
resolver
uniprot
Q8N596
resolver
uniprot
Q9BZB0
resolver
uniprot
Q9P1Z4
resolver
uniprot_entry
A8KAD5_HUMAN
resolver
uniprot_entry
OSBL5_HUMAN
resolver
uniprot_sec
A6NDP0
resolver
uniprot_sec
A6NJS8
resolver
uniprot_sec
B4DVB0
resolver
uniprot_sec
Q54A90
resolver
uniprot_sec
Q8N596
resolver
uniprot_sec
Q9BZB0
resolver
uniprot_sec
Q9P1Z4
resolver
amino_acid_sequence
MKEEAFLRRRFSLCPPSSTPQKVDPRKLTRNLLLSGDNELYPLSPGKDMEPNGPSLPRDEGPPTPSSATKVPPAEYRLCNGSDKECVSPTARVTKKETLKAQKENYRQEKKRATRQLLSALTDPSVVIMADSLKIRGTLKSWTKLWCVLKPGVLLIYKTPKVGQWVGTVLLHCCELIERPSKKDGFCFKLFHPLDQSVWAVKGPKGESVGSITQPLPSSYLIFRAASESDGRCWLDALELALRCSSLLRLGTCKPGRDGEPGTSPDASPSSLCGLPASATVHPDQDLFPLNGSSLENDAFSDKSERENPEESDTETQDHSRKTESGSDQSETPGAPVRRGTTYVEQVQEELGELGEASQVETVSEENKSLMWTLLKQLRPGMDLSRVVLPTFVLEPRSFLNKLSDYYYHADLLSRAAVEEDAYSRMKLVLRWYLSGFYKKPKGIKKPYNPILGETFRCCWFHPQTDSRTFYIAEQVSHHPPVSAFHVSNRKDGFCISGSITAKSRFYGNSLSALLDGKATLTFLNRAEDYTLTMPYAHCKGILYGTMTLELGGKVTIECAKNNFQAQLEFKLKPFFGGSTSINQISGKITSGEEVLASLSGHWDRDVFIKEEGSGSSALFWTPSGEVRRQRLRQHTVPLEEQTELESERLWQHVTRAISKGDQHRATQEKFALEEAQRQRARERQESLMPWKPQLFHLDPITQEWHYRYEDHSPWDPLKDIAQFEQDGILRTLQQEAVARQTTFLGSPGPRHERSGPDQRLRKASDQPSGHSQATESSGSTPESCPELSDEEQDGDFVPGGESPCPRCRKEARRLQALHEAILSIREAQQELHRHLSAMLSSTARAAQAPTPGLLQSPRSWFLLCVFLACQLFINHILK
uniprot
proteins
function
FUNCTION: Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:23934110, PubMed:26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:21220512, ECO:0000269|PubMed:23934110, ECO:0000269|PubMed:26206935}.
uniprot
proteins
mass_dalton
98616
uniprot
proteins
mutagenesis
MUTAGEN 389; /note="L->D: Impaired lipid countertransport between the endoplasmic reticulum and the plasma membrane."; /evidence="ECO:0000269|PubMed:26206935"; MUTAGEN 478..479; /note="HH->AA: Impaired lipid countertransport between the endoplasmic reticulum and the plasma membrane."; /evidence="ECO:0000269|PubMed:26206935
uniprot
proteins
protein_family
OSBP family
uniprot
proteins
pubmed
10819331
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
11483621
uniprot
proteins
pubmed
11735225
uniprot
proteins
pubmed
12504849
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17428193
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20644730
uniprot
proteins
pubmed
21220512
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23934110
uniprot
proteins
pubmed
26206935
uniprot
proteins
pubmed
30220461
uniprot
proteins
sequence_length
879
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21220512, ECO:0000269|PubMed:26206935}; Single-pass membrane protein {ECO:0000269|PubMed:21220512}. Note=Localizes to endoplasmic reticulum-plasma membrane contact sites (EPCS). Localizes to the cortical endoplasmic reticulum at the EPCS. {ECO:0000269|PubMed:26206935, ECO:0000269|PubMed:30220461}.
uniprot
proteins
transmembrane_region
TRANSMEM 860..878; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins