Slc28a3
entrez
140944
canonical
uniprot
Q8VIH3
canonical
ensembl
ENSRNOG00000018853
resolver
ensp
ENSRNOP00000025745
resolver
ensp
ENSRNOP00000102142
resolver
enst
ENSRNOT00000025745
resolver
enst
ENSRNOT00000159704
resolver
genesymbol
Slc28a3
resolver
genesymbol_syn
Cnt3
resolver
uniprot
A0ABK0LC51
resolver
uniprot
G3V8H0
resolver
uniprot_entry
A0ABK0LC51_RAT
resolver
uniprot_entry
G3V8H0_RAT
resolver
uniprot_entry
S28A3_RAT
resolver
amino_acid_sequence
MSRSDPDPGKNSEPSKSKMSLELRPTAPSDQGRLNEAFQDEDLEEQNAPGNSTVRSRVVQSGEQGRAKQDDRQITIEQEPLGPKEGTEEESEDERQKGFLERKYDTVCEFCRKHRVILQHTIWAVLLTGFLALVIAACALNFHRALPLFVITLVTIFFVVWDRLMAKYEQRIDDVLSPGKRLLERHWFWLKWVVWCSLILAVILWLALDTARLGQQQLISFGGLVMYIVLLFLFSKHPTRVYWRPVFWGIGLQFLLGLLILRTRPGFVAFDWMGKQVQTFLGYTDAGAQFVFGEKYTDHFFAFKILPIVVFFSTVMSMLYYLGLMQWIIRKVGWLMLVTMGSSPIESVVAAGNIFVGQTESPLLVQPYLPHVTKSELHTIMTAGFATIAGSVLGAYISFGVSSTHLLTASVMSAPAALAVAKLFWPETEKPKITLKNAMKMENGDSRNLLEAATQGASSSIPLVANIAANLIAFLALLSFVNSALSWFGSMFDYPQLSFELICSYIFMPFSFMMGVDWQDRFMVAKLIGYKTFFNEFVAYEHLSKFINLRKAAGPKFVNGVQQYMSIRSETIATYALCGFANFGSLGIVIGGLTSIAPSRKRDIASGAMRALIAGTIACFMTACIAGMLSDTPVAINCHHVLESSKVLSNTTEVASCCQGLFNSTVARGPNDVLPGGNFSLYTLKSCCNLLKPPTLNCGWIPNIP
uniprot
proteins
function
FUNCTION: Sodium-dependent, pyrimidine- and purine-selective. Involved in the homeostasis of endogenous nucleosides. Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine). Employs a 2:1 sodium/nucleoside ratio. Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine. {ECO:0000250|UniProtKB:Q9HAS3}.
uniprot
proteins
mass_dalton
78374
uniprot
proteins
protein_family
Concentrative nucleoside transporter (CNT) (TC 2.A.41) family
uniprot
proteins
pubmed
16014043
uniprot
proteins
sequence_length
705
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9HAS3}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 120..140; /note="Helical; Name=TM1"; /evidence="ECO:0000250|UniProtKB:Q9HAS3"; TRANSMEM 146..166; /note="Helical; Name=TM2"; /evidence="ECO:0000250|UniProtKB:Q9HAS3"; TRANSMEM 191..211; /note="Helical; Name=TM3"; /evidence="ECO:0000250|UniProtKB:Q9HAS3"; TRANSMEM 215..236; /note="Helical; Name=TM4"; /evidence="ECO:0000250|UniProtKB:Q9HAS3"; TRANSMEM 245..264; /note="Helical; Name=TM5"; /evidence="ECO:0000250|UniProtKB:Q9HAS3"; TRANSMEM 302..322; /note="Helical; Name=TM6"; /evidence="ECO:0000250|UniProtKB:Q9HAS3"; TRANSMEM 379..401; /note="Helical; Name=TM7"; /evidence="ECO:0000250|UniProtKB:Q9HAS3"; TRANSMEM 404..425; /note="Helical; Name=TM8"; /evidence="ECO:0000250|UniProtKB:Q9HAS3"; TRANSMEM 461..486; /note="Helical; Name=TM9"; /evidence="ECO:0000250|UniProtKB:Q9HAS3"; TRANSMEM 584..594; /note="Helical; Name=TM10"; /evidence="ECO:0000250|UniProtKB:Q9HAS3"; TRANSMEM 608..630; /note="Helical; Name=TM11"; /evidence="ECO:0000250|UniProtKB:Q9HAS3
uniprot
proteins