CRYZ
entrez
1429
canonical
uniprot
Q08257
canonical
ensembl
ENSG00000116791
resolver
ensp
ENSP00000339399
resolver
ensp
ENSP00000359907
resolver
ensp
ENSP00000359908
resolver
ensp
ENSP00000359909
resolver
ensp
ENSP00000558668
resolver
ensp
ENSP00000558695
resolver
genesymbol
CRYZ
resolver
hgnc
HGNC:2419
resolver
uniprot
A6NN60
resolver
uniprot
D3DQ76
resolver
uniprot
Q53FT0
resolver
uniprot
Q59EU7
resolver
uniprot
Q5HYE7
resolver
uniprot
Q6NSK9
resolver
uniprot_entry
QOR_HUMAN
resolver
uniprot_sec
A6NN60
resolver
uniprot_sec
D3DQ76
resolver
uniprot_sec
Q53FT0
resolver
uniprot_sec
Q59EU7
resolver
uniprot_sec
Q5HYE7
resolver
uniprot_sec
Q6NSK9
resolver
amino_acid_sequence
MATGQKLMRAVRVFEFGGPEVLKLRSDIAVPIPKDHQVLIKVHACGVNPVETYIRSGTYSRKPLLPYTPGSDVAGVIEAVGDNASAFKKGDRVFTSSTISGGYAEYALAADHTVYKLPEKLDFKQGAAIGIPYFTAYRALIHSACVKAGESVLVHGASGGVGLAACQIARAYGLKILGTAGTEEGQKIVLQNGAHEVFNHREVNYIDKIKKYVGEKGIDIIIEMLANVNLSKDLSLLSHGGRVIVVGSRGTIEINPRDTMAKESSIIGVTLFSSTKEEFQQYAAALQAGMEIGWLKPVIGSQYPLEKVAEAHENIIHGSGATGKMILLL
uniprot
proteins
ec_number
1.6.5.5
uniprot
proteins
function
FUNCTION: Multifunctional crystallin endowed with unrelated mRNA stabilization and enzymatic oxidoreductase activities (PubMed:17497241, PubMed:20103721). Binds (AU)-rich elements (ARE) in the 3'-UTR of target mRNA to enhance their stability (PubMed:17497241, PubMed:20103721). Upon metabolic acidosis, stabilizes the mRNA encoding SLC12A1 a cotransporter involved in transepithelial NH4(+) reabsorption in the medullary thick ascending limb in kidney (By similarity). In response to acidosis, also participates to the adaptive increase in renal ammoniagenesis by stabilizing the mRNAs of enzymes involved in glutamine catabolism (By similarity). By the same mechanism, it also regulates the expression of the antiapoptotic protein BCL2 (PubMed:20103721). Beside its mRNA stabilization activity, also catalyzes the reduction of orthoquinones such as 1,2-naphthoquinone or 9,10-phenanthrenequinone in the presence of NADPH in vitro and could be involved in the detoxification of xenobiotics and protection against oxidative stress (PubMed:17497241). {ECO:0000250|UniProtKB:P47199, ECO:0000250|UniProtKB:Q6AYT0, ECO:0000269|PubMed:17497241, ECO:0000269|PubMed:20103721}.
uniprot
proteins
mass_dalton
35207
uniprot
proteins
protein_family
Quinone oxidoreductase subfamily
uniprot
proteins
protein_family
Zinc-containing alcohol dehydrogenase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17497241
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20103721
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
8088825
uniprot
proteins
pubmed
8466529
uniprot
proteins
sequence_length
329
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:20103721}.
uniprot
proteins