Alox12e
entrez
11685
canonical
uniprot
P55249
canonical
ensembl
ENSMUSG00000018907
resolver
ensp
ENSMUSP00000019051
resolver
enst
ENSMUST00000019051
resolver
genesymbol
Alox12e
resolver
genesymbol_syn
Alox12-ps2
resolver
genesymbol_syn
Aloxe
resolver
uniprot
Q5F2E4
resolver
uniprot
Q91YW6
resolver
uniprot_entry
LX12E_MOUSE
resolver
uniprot_entry
Q5F2E4_MOUSE
resolver
uniprot_sec
Q91YW6
resolver
activity_regulation
ACTIVITY REGULATION: Arachidonate 12-lipoxygenase activity is decreased when the pH decreases from 7.4 to 6.0. {ECO:0000269|PubMed:11256953}.
uniprot
proteins
amino_acid_sequence
MVKYKILVATGDSVFAGSANLVHLWLVGEHGEADLGKQLRPLLGRKTELEVDVPLHLGRLLAVKLRKQKGLLDSDWFCKSITVQGPGTQGEAFFPCYSWVQGKETICLTEGTALKVTDDTQNLFRKYREQELENRRNVYRWGSWKEGLILPIAGSTERDLPRNQRFMKDKDLDFSLSLVKELKNFAIKGTLDFVSRVQKLEDYQKVFPHTKTALPERVRGSWKEDALFGYQFLNGANPMLLRRSMRLPARLVLPPGMEDVQTQLEKELKAGSLFEVDFSLLDGVKPNIIIFKQQYVTAPLVMLKLQPDGRLLPMVIQLQPPRHGCPPPLLFLPSDPPMAWLLAKIWVRSSDFQLHQLQSHLLRGHLMAEVISVATMRSLPSLHPIYKLLAPHFRYTMEINTLARNNLVSEWGIFDLVVSTGSGGHVDILQRATSCLTYRSFCPPDDLADRGLVGVKSSLYAQDALRLWEIISRYVERMVELFYRSDTDVKEDPELQVWCREVTEVGLLGAQDRGFPLSLESRAELCRFVAMCIFTCTGQHASTHLGQLDWYAWIPNGPCTMRKPPPISKDVTERDIVDSLPCLQQARMQITVTKFLGRRQPVMVALGQHKEEYFSGPRPRDVLKQFQEELAIMDKEIEVRNASLDLPYEYLRPSLVENSVTI
uniprot
proteins
ec_number
1.13.11.-
uniprot
proteins
ec_number
1.13.11.31
uniprot
proteins
function
FUNCTION: Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:11256953, PubMed:8798535, PubMed:9037187). Shows increasing catalytic activity within the series arachidonic acid < 5,8,11-eicosatrienoic acid < linoleic acid < 8,11,14-eicosatrienoic acid (PubMed:11256953). {ECO:0000269|PubMed:11256953, ECO:0000269|PubMed:8798535, ECO:0000269|PubMed:9037187}.
uniprot
proteins
mass_dalton
75456
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis.
uniprot
proteins
protein_family
Lipoxygenase family
uniprot
proteins
pubmed
11256953
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7492614
uniprot
proteins
pubmed
8798535
uniprot
proteins
pubmed
9037187
uniprot
proteins
sequence_length
662
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00726}.
uniprot
proteins