CFLAR
entrez
8837
canonical
uniprot
O15519
canonical
ensembl
ENSG00000003402
resolver
ensp
ENSP00000312455
resolver
ensp
ENSP00000339335
resolver
ensp
ENSP00000345807
resolver
ensp
ENSP00000378580
resolver
ensp
ENSP00000399420
resolver
ensp
ENSP00000406775
resolver
ensp
ENSP00000413270
resolver
ensp
ENSP00000471805
resolver
ensp
ENSP00000648516
resolver
ensp
ENSP00000790030
resolver
enst
ENST00000395148
resolver
genesymbol
CFLAR
resolver
genesymbol_syn
CASH
resolver
genesymbol_syn
CASP8AP1
resolver
genesymbol_syn
CLARP
resolver
genesymbol_syn
MRIT
resolver
hgnc
HGNC:1876
resolver
uniprot
A0A024R3Y4
resolver
uniprot
A0A024R3Z7
resolver
uniprot
A0A336TY74
resolver
uniprot
B4DJE0
resolver
uniprot
B4E361
resolver
uniprot
B7Z9F9
resolver
uniprot
E9PAP3
resolver
uniprot
O14673
resolver
uniprot
O14674
resolver
uniprot
O14675
resolver
uniprot
O15137
resolver
uniprot
O15138
resolver
uniprot
O15356
resolver
uniprot
O15510
resolver
uniprot
O43618
resolver
uniprot
O43619
resolver
uniprot
O43620
resolver
uniprot
O60458
resolver
uniprot
O60459
resolver
uniprot
Q53TS6
resolver
uniprot
Q54AF1
resolver
uniprot
Q59F61
resolver
uniprot
Q96TE4
resolver
uniprot
Q9UEW1
resolver
uniprot_entry
A0A024R3Y4_HUMAN
resolver
uniprot_entry
A0A336TY74_HUMAN
resolver
uniprot_entry
B4E361_HUMAN
resolver
uniprot_entry
CFLAR_HUMAN
resolver
uniprot_entry
E9PAP3_HUMAN
resolver
uniprot_entry
Q59F61_HUMAN
resolver
uniprot_sec
A0A024R3Z7
resolver
uniprot_sec
B4DJE0
resolver
uniprot_sec
B7Z9F9
resolver
uniprot_sec
O14673
resolver
uniprot_sec
O14674
resolver
uniprot_sec
O14675
resolver
uniprot_sec
O15137
resolver
uniprot_sec
O15138
resolver
uniprot_sec
O15356
resolver
uniprot_sec
O15510
resolver
uniprot_sec
O43618
resolver
uniprot_sec
O43619
resolver
uniprot_sec
O43620
resolver
uniprot_sec
O60458
resolver
uniprot_sec
O60459
resolver
uniprot_sec
Q53TS6
resolver
uniprot_sec
Q54AF1
resolver
uniprot_sec
Q96TE4
resolver
uniprot_sec
Q9UEW1
resolver
amino_acid_sequence
MSAEVIHQVEEALDTDEKEMLLFLCRDVAIDVVPPNVRDLLDILRERGKLSVGDLAELLYRVRRFDLLKRILKMDRKAVETHLLRNPHLVSDYRVLMAEIGEDLDKSDVSSLIFLMKDYMGRGKISKEKSFLDLVVELEKLNLVAPDQLDLLEKCLKNIHRIDLKTKIQKYKQSVQGAGTSYRNVLQAAIQKSLKDPSNNFRLHNGRSKEQRLKEQLGAQQEPVKKSIQESEAFLPQSIPEERYKMKSKPLGICLIIDCIGNETELLRDTFTSLGYEVQKFLHLSMHGISQILGQFACMPEHRDYDSFVCVLVSRGGSQSVYGVDQTHSGLPLHHIRRMFMGDSCPYLAGKPKMFFIQNYVVSEGQLEDSSLLEVDGPAMKNVEFKAQKRGLCTVHREADFFWSLCTADMSLLEQSHSSPSLYLQCLSQKLRQERKRPLLDLHIELNGYMYDWNSRVSAKEKYYVWLQHTLRKKLILSYT
uniprot
proteins
function
FUNCTION: Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells (PubMed:31046799). Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity. {ECO:0000269|PubMed:31046799, ECO:0000269|PubMed:9880531}.
uniprot
proteins
mass_dalton
55344
uniprot
proteins
mutagenesis
MUTAGEN 360; /note="Y->F: Decreases apoptosis-inducing activity. Reduces interaction with caspase-3 and proteolytic processing."; /evidence="ECO:0000269|PubMed:9208847"; MUTAGEN 376; /note="D->N,A: Abolishes proteolytic processing."; /evidence="ECO:0000269|PubMed:9228018
uniprot
proteins
post_translational_modification
PTM: Proteolytically processed by CASP8 generating subunit p43 and p12. {ECO:0000269|PubMed:9228018}.; PTM: Deubiquitinated by USP40, leading to stabilization. {ECO:0000269|PubMed:31046799}.
uniprot
proteins
protein_family
Peptidase C14A family
uniprot
proteins
pubmed
10200473
uniprot
proteins
pubmed
10227994
uniprot
proteins
pubmed
11161814
uniprot
proteins
pubmed
12727877
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14759258
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
31046799
uniprot
proteins
pubmed
9208847
uniprot
proteins
pubmed
9211860
uniprot
proteins
pubmed
9217161
uniprot
proteins
pubmed
9228018
uniprot
proteins
pubmed
9289491
uniprot
proteins
pubmed
9326610
uniprot
proteins
pubmed
9380701
uniprot
proteins
pubmed
9880531
uniprot
proteins
sequence_length
480
uniprot
proteins