TNFSF10
entrez
8743
canonical
uniprot
P50591
canonical
ensembl
ENSG00000121858
resolver
ensp
ENSP00000241261
resolver
ensp
ENSP00000389931
resolver
ensp
ENSP00000670735
resolver
genesymbol
TNFSF10
resolver
genesymbol_syn
APO2L
resolver
genesymbol_syn
TRAIL
resolver
hgnc
HGNC:11925
resolver
uniprot
A1Y9B3
resolver
uniprot
Q6IBA9
resolver
uniprot_entry
Q6IBA9_HUMAN
resolver
uniprot_entry
TNF10_HUMAN
resolver
uniprot_sec
A1Y9B3
resolver
amino_acid_sequence
MAMMEVQGGPSLGQTCVLIVIFTVLLQSLCVAVTYVYFTNELKQMQDKYSKSGIACFLKEDDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQEKQQNISPLVRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG
uniprot
proteins
function
FUNCTION: Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:10549288, PubMed:26457518). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. {ECO:0000269|PubMed:10549288, ECO:0000269|PubMed:26457518}.
uniprot
proteins
mass_dalton
32509
uniprot
proteins
post_translational_modification
PTM: Tyrosine phosphorylated by PKDCC/VLK. {ECO:0000269|PubMed:25171405}.
uniprot
proteins
protein_family
Tumor necrosis factor family
uniprot
proteins
pubmed
10485660
uniprot
proteins
pubmed
10542098
uniprot
proteins
pubmed
10549288
uniprot
proteins
pubmed
14609566
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
21859711
uniprot
proteins
pubmed
25171405
uniprot
proteins
pubmed
26457518
uniprot
proteins
pubmed
8663110
uniprot
proteins
pubmed
8777713
uniprot
proteins
sequence_length
281
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14609566}; Single-pass type II membrane protein {ECO:0000305}. Secreted {ECO:0000269|PubMed:14609566}. Note=Exists both as membrane-bound and soluble form. {ECO:0000269|PubMed:14609566}.
uniprot
proteins
transmembrane_region
TRANSMEM 18..38; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins