Afg2b
entrez
214616
canonical
uniprot
A0A7N9VSG0
canonical
ensembl
ENSMUSG00000118663
resolver
ensp
ENSMUSP00000159384
resolver
enst
ENSMUST00000239506
resolver
genesymbol
Afg2b
resolver
genesymbol_syn
Spata5l1
resolver
uniprot
Q3TER3
resolver
uniprot_entry
AFG2B_MOUSE
resolver
uniprot_entry
Q3TER3_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: In the context of 55LCC heterohexameric ATPase complex, the ATPase activity is stimulated by DNA binding and inhibited in presence of RNA. {ECO:0000250|UniProtKB:Q9BVQ7}.
uniprot
proteins
amino_acid_sequence
MAPDSGPFPDGQLLKLLPVDPRDRDTQRCRLGPAAFRSLGARLGSPLRISLPAGGCCLCTAWPRRDRVDGFVQLDPQCASPGARVATGRIGMDCLQPVPCPPLRRLEVWPVLRPQAGAPSSAAVLEVVHELLRNRPVSRGHVVTTPPGVPGPVAALHVMGGTPDPEPGGWVTPHTRITLSDKPPPQVEPPGEVTLGGLSETADSLRELLRLPLRYPLALAALGLAVPRGVLLAGPPGVGKTQLVRAVARETGAELLAVSAPALQGSRPGETEENVRRIFQRAQELASRGPSLLFLDEVDALCPRRGGPHRAPESRVVAQVLTLLDGIHRDREFVVVGATNRPDELDPALRRPGRFDREVVIGTPTLKQREAILQVITSKMPISSHIDLGLLAEMTVGYVGADLTALCREAAMCALLKNEKNQDSPKIEETDFLEAFKKIQPSSFRSSTGLMDIKPVGWEQIGGLEDVKLKLKQCVEWPLKFPQEFARMGLTQPKGLLLYGPPGCAKTTLVRALATGCHCSFVSVCGADLFSPFVGDSEKVLSQVFRQARANTPALVFLDEIDSVLGSRSVGTSGCDARERVLSVLLNELDGVGVRTVERRGSKASQQECQEILSRSVMIVVATNRPDVLDDALLRPGRLDKIIYVPPPDQEGRLSILKVCTNNMPVGPDVSLENLAAETCFFSGADLRNLCKEAALFALQENGLEATTVRQEHFTEALKTVKPSLTLKELTFYENLFKKGLSNLEDD
uniprot
proteins
ec_number
3.6.4.10
uniprot
proteins
function
FUNCTION: ATP-dependent chaperone part of the 55LCC heterohexameric ATPase complex which is chromatin-associated and promotes replisome proteostasis to maintain replication fork progression and genome stability. Required for replication fork progression, sister chromatid cohesion, and chromosome stability. The ATPase activity is specifically enhanced by replication fork DNA and is coupled to cysteine protease-dependent cleavage of replisome substrates in response to replication fork damage. Uses ATPase activity to process replisome substrates in S-phase, facilitating their proteolytic turnover from chromatin to ensure DNA replication and mitotic fidelity. Plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles. {ECO:0000250|UniProtKB:Q9BVQ7}.
uniprot
proteins
mass_dalton
80742
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
protein_family
AFG2 subfamily
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
34626583
uniprot
proteins
sequence_length
747
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BVQ7}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9BVQ7}. Nucleus {ECO:0000250|UniProtKB:D4A2B7}.
uniprot
proteins