Majin
entrez
622554
canonical
uniprot
Q9D992
canonical
ensembl
ENSMUSG00000024786
resolver
ensp
ENSMUSP00000025699
resolver
ensp
ENSMUSP00000109156
resolver
ensp
ENSMUSP00000333597
resolver
genesymbol
Majin
resolver
uniprot
E9Q4N4
resolver
uniprot_entry
MAJIN_MOUSE
resolver
uniprot_sec
E9Q4N4
resolver
amino_acid_sequence
MSLKPFTYPFPETRFLHAGPNVYKFKIRYGNSIRGEEIEDKEVIVQELEDSIRAVLANMDSLQPFVTEHFIVFPYKSKWERVSHLKFKHGESILTPYPFVFTLYIEMKWFAEDLPSGKPADDIPLELVLAETEAEEATMRKWKRKLMEEPSSPSRQGPHRAKMETSSEASSNKKPLKESKRSTDEEAQQEYQDTPASNAIAVKEQDAALGHGLQGLVVPPLQHSSPPPPKEPGARGFLGFLSALFPFRYFFKKSGQ
uniprot
proteins
function
FUNCTION: Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane. {ECO:0000269|PubMed:26548954}.
uniprot
proteins
mass_dalton
29175
uniprot
proteins
mutagenesis
MUTAGEN 140..145; /note="RKWKRK->AAWAAA: Impaired DNA-binding activity."; /evidence="ECO:0000269|PubMed:26548954
uniprot
proteins
protein_family
MAJIN family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26548954
uniprot
proteins
sequence_length
256
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000269|PubMed:26548954}; Single-pass membrane protein {ECO:0000305|PubMed:26548954}. Chromosome, telomere {ECO:0000269|PubMed:26548954}. Note=Localizes to telomeres throughout meiotic prophase I and disappears in metaphase I. In leptotene spermatocytes, localizes to telomeres that localize to the nucleus inner membrane. {ECO:0000269|PubMed:26548954}.
uniprot
proteins
transmembrane_region
TRANSMEM 233..251; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins