NR1H3
entrez
10062
canonical
uniprot
Q13133
canonical
ensembl
ENSG00000025434
resolver
ensp
ENSP00000378793
resolver
ensp
ENSP00000384745
resolver
ensp
ENSP00000385073
resolver
ensp
ENSP00000387946
resolver
ensp
ENSP00000420656
resolver
ensp
ENSP00000477707
resolver
ensp
ENSP00000566785
resolver
ensp
ENSP00000566789
resolver
ensp
ENSP00000566801
resolver
ensp
ENSP00000635518
resolver
ensp
ENSP00000635521
resolver
enst
ENST00000405576
resolver
enst
ENST00000616973
resolver
genesymbol
NR1H3
resolver
genesymbol_syn
LXRA
resolver
hgnc
HGNC:7966
resolver
uniprot
A0A087WTA3
resolver
uniprot
A8K3J9
resolver
uniprot
B4DXU5
resolver
uniprot
B5MBY7
resolver
uniprot
D3DQR1
resolver
uniprot
F1D8N1
resolver
uniprot
Q8IW13
resolver
uniprot
Q96H87
resolver
uniprot_entry
A0A087WTA3_HUMAN
resolver
uniprot_entry
B4DXU5_HUMAN
resolver
uniprot_entry
B5MBY7_HUMAN
resolver
uniprot_entry
F1D8N1_HUMAN
resolver
uniprot_entry
NR1H3_HUMAN
resolver
uniprot_sec
A8K3J9
resolver
uniprot_sec
D3DQR1
resolver
uniprot_sec
Q8IW13
resolver
uniprot_sec
Q96H87
resolver
amino_acid_sequence
MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAAEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGFFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKRQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMAPDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIAISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
uniprot
proteins
function
FUNCTION: Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:19481530, PubMed:25661920, PubMed:37478846). Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES (PubMed:37478846). LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides (By similarity). Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 (PubMed:19481530). Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity). {ECO:0000250|UniProtKB:Q9Z0Y9, ECO:0000269|PubMed:19481530, ECO:0000269|PubMed:25661920, ECO:0000269|PubMed:37478846}.
uniprot
proteins
mass_dalton
50396
uniprot
proteins
mutagenesis
MUTAGEN 268..273; /note="IVDFAK->EVDFAE: Abolishes interaction with NCOA2 without affecting interaction with GPS2; when associated with 438-A-A-439."; /evidence="ECO:0000269|PubMed:19481530"; MUTAGEN 438..439; /note="LL->AA: Abolishes interaction with NCOA2 without affecting interaction with GPS2; when associated with 268-A--A-273."; /evidence="ECO:0000269|PubMed:19481530
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by UBR5, leading to its degradation: UBR5 specifically recognizes and binds ligand-bound NR1H3 when it is not associated with coactivators (NCOAs) (PubMed:37478846). In presence of NCOAs, the UBR5-degron is not accessible, preventing its ubiquitination and degradation (PubMed:37478846). {ECO:0000269|PubMed:37478846}.
uniprot
proteins
protein_family
NR1 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
19481530
uniprot
proteins
pubmed
25661920
uniprot
proteins
pubmed
37478846
uniprot
proteins
pubmed
7744246
uniprot
proteins
sequence_length
447
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:25661920}. Cytoplasm {ECO:0000250|UniProtKB:Q9Z0Y9}.
uniprot
proteins