NTMT2
entrez
149281
canonical
uniprot
Q5VVY1
canonical
ensembl
ENSG00000203740
resolver
ensp
ENSP00000408058
resolver
enst
ENST00000439373
resolver
genesymbol
NTMT2
resolver
genesymbol_syn
C1orf184
resolver
genesymbol_syn
METTL11B
resolver
genesymbol_syn
NRMT2
resolver
hgnc
HGNC:31932
resolver
uniprot
B2RXI0
resolver
uniprot_entry
NTM1B_HUMAN
resolver
uniprot_sec
B2RXI0
resolver
amino_acid_sequence
MAHRGAHFAFRSRWQKTDDELCRHSMSFILHKAIRNDFFQSYLYLLEKIPLVKLYALTSQVINGEMQFYARAKLFYQEVPATEEGMMGNFIELSSPDIQASQKFLRKFVGGPGRAGTDCALDCGSGIGRVSKHVLLPVFNSVELVDMMESFLLEAQNYLQVKGDKVESYHCYSLQEFTPPFRRYDVIWIQWVSGHLTDKDLLAFLSRCRDGLKENGIIILKDNVAREGCILDLSDSSVTRDMDILRSLIRKSGLVVLGQEKQDGFPEQCIPVWMFALHSDRHS
uniprot
proteins
ec_number
2.1.1.299
uniprot
proteins
function
FUNCTION: Alpha N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]-Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif (PubMed:24090352, PubMed:30417120). Predominantly functions as a mono-methyltransferase but is also able to di-/tri-methylate the GPKRIA peptide and di-methylate the PPKRIA peptide (in vitro) (PubMed:30417120). May activate NTMT1 by priming its substrates for trimethylation (PubMed:24090352). {ECO:0000269|PubMed:24090352, ECO:0000269|PubMed:30417120}.
uniprot
proteins
mass_dalton
32400
uniprot
proteins
mutagenesis
MUTAGEN 89; /note="N->G: Increases methylation activity. Higher affinity for mono-methylated peptide than wild-type."; /evidence="ECO:0000269|PubMed:30417120
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
protein_family
NTM1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
24090352
uniprot
proteins
pubmed
30417120
uniprot
proteins
sequence_length
283
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24090352}.
uniprot
proteins