Heph
entrez
15203
canonical
uniprot
Q9Z0Z4
canonical
ensembl
ENSMUSG00000031209
resolver
ensp
ENSMUSP00000033553
resolver
ensp
ENSMUSP00000078301
resolver
ensp
ENSMUSP00000109469
resolver
ensp
ENSMUSP00000227801
resolver
enst
ENSMUST00000079322
resolver
genesymbol
Heph
resolver
genesymbol_syn
Kiaa0698
resolver
uniprot
A2AI62
resolver
uniprot
A2AI63
resolver
uniprot
Q6ZQ65
resolver
uniprot
Q80Y80
resolver
uniprot
Q8C4S2
resolver
uniprot_entry
A2AI62_MOUSE
resolver
uniprot_entry
HEPH_MOUSE
resolver
uniprot_sec
A2AI63
resolver
uniprot_sec
Q6ZQ65
resolver
uniprot_sec
Q80Y80
resolver
uniprot_sec
Q8C4S2
resolver
amino_acid_sequence
MKAGHLLWALLLMHSLWSIPTDGAIRNYYLGIQDMQWNYAPKGRNVITNQTLNNDTVASSFLKSGKNRIGSSYKKTVYKEYSDGTYTEEIAKPAWLGFLGPLLQAEVGDVILIHLKNFASRPYTIHPHGVFYEKDSEGSLYPDGSSGYLKADDSVPPGGSHVYNWSIPESHAPTEADPACLTWIYHSHVDAPRDIATGLIGPLITCKRGTLDGNSPPQRKDVDHNFFLLFSVIDENLSWHLDDNIATYCSDPASVDKEDGAFQDSNRMHAINGFVFGNLPELSMCAQKHVAWHLFGMGNEIDVHTAFFHGQMLSIRGHHTDVANIFPATFVTAEMVPQKSGTWLISCEVNSHLRSGMQAFYKVDSCSMDPPVDQLTGKVRQYFIQAHEIQWDYGPIGYDGRTGKSLREPGSGPDKYFQKSSSRIGGTYWKVRYEAFQDETFQERVHQEEETHLGILGPVIRAEVGDTIQVVFYNRASQPFSIQPHGVFYEKNSEGTVYNDGTSHPKVAKSFEKVTYYWTVPPHAGPTAQDPACLTWMYFSAADPTRDTNSGLVGPLLVCKAGALGADGKQKGVDKEFFLLFTVFDENESWYNNANQAAGMLDSRLLSEDVEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFEGNTVQLQGMRKGAVMLFPHTFVTAIMQPDNPGIFEIYCQAGSHREEGMQAIYNVSQCSSHQDSPRQHYQASRVYYIMAEEIEWDYCPDRSWELEWHNTSEKDSYGHVFLSNKDGLLGSKYKKAVFREYTDGTFRIPRPRSGPEEHLGILGPLIRGEVGDILTVVFKNKASRPYSIHAHGVLESNTGGPQAAEPGEVLTYQWNIPERSGPGPSDSACVSWIYYSAVDPIKDMYSGLVGPLVICRNGILEPNGGRNDMDREFALLFLIFDENQSWYLKENIATYGPQESSHVNLKDATFLESNKMHAINGKLYANLRGLTVYQGERVAWYMLAMGQDTDIHTVHFHAESFLYQNGQSYRADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETIFTVLSHEEHFSTMTTITKEIGKAVILRDIGGDNVKMLGMNIPIKDVEILSSALIAICVLLLLIALALGGVVWYQHRQRKLRRNRRSILDDSFKLLSLKQ
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Heph are a cause of the sex-linked anemia (sla) that is characterized by moderate to severe microcytic hypochronic anemia with iron accumulation in the intestinal epithelium. {ECO:0000269|PubMed:9988272}.
uniprot
proteins
ec_number
1.16.3.1
uniprot
proteins
function
FUNCTION: Plasma membrane ferroxidase that mediates the extracellular conversion of ferrous/Fe(2+) iron into its ferric/Fe(3+) form (PubMed:14751926). Couples ferroportin which specifically exports ferrous/Fe(2+) iron from cells to transferrin that only binds and shuttles extracellular ferric/Fe(3+) iron throughout the body. By helping iron transfer from cells to blood mainly contributes to dietary iron absorption by the intestinal epithelium and more generally regulates iron levels in the body (PubMed:14751926, PubMed:30647129, PubMed:9988272). {ECO:0000269|PubMed:14751926, ECO:0000269|PubMed:30647129, ECO:0000269|PubMed:9988272}.
uniprot
proteins
mass_dalton
129666
uniprot
proteins
protein_family
Multicopper oxidase family
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
14751926
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30647129
uniprot
proteins
pubmed
9988272
uniprot
proteins
sequence_length
1157
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000250|UniProtKB:Q9BQS7}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 1110..1130; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins