Stag3
entrez
114522
canonical
uniprot
Q99M76
canonical
ensembl
ENSRNOG00000001360
resolver
ensp
ENSRNOP00000041918
resolver
ensp
ENSRNOP00000110662
resolver
enst
ENSRNOT00000042006
resolver
enst
ENSRNOT00000162804
resolver
genesymbol
Stag3
resolver
uniprot
A0ABK0M2W7
resolver
uniprot_entry
A0ABK0M2W7_RAT
resolver
uniprot_entry
STAG3_RAT
resolver
amino_acid_sequence
MPTLWSPSTQHHGSSSGSMSSPLRKSVRCAQMALSPCSSNIQPCDDRDSQGTAEWDSSSTSEDSDFEDSLRRNVRKRAAKRPPKAIPVAKHPKKQSHIVPGGNDKNKSVPPTSDLFDAVKAARSCAQSLVDEWLENYKQDENAGFLELVNFFIRACGCKSTVTPEMFKTMSNSEIIQHLTEEFNEDSGDYPLTAPGPSWKKFQGSFCEFVKTLVCQCQYSLLFDGFPMDDLISLLIGLSDSQVRAFRHTSTLAAMKLMTSLVKVALQLSLHKDNNQRQYEAERNKGPEQRAPERLESLLEKRKEFQENQEEIEGMMNAIFRGVFVHRYRDILPEIRAVCIEEIGCWMQSYSTSFLNDSYLKYIGWTLHDKHKEVRLKCVKALAGLYSNQELSSRMELFTNRFKDRMVSMVMDRESEVAVEAIRLLTLILKNMEGVLTSADCEKIYSIVYISNRAMASSAGEFVYWKIFHPECGAKAVSGRERRRSPQAQRTFIYLLLAFFMESEHHDHAAYLVDSLWDCAGSYLKDWESLTSLLLQKDQNLGDMQERMLIEILVSSARQAAEGHPPVGRITGKKSLTAKERKLQAYDKVKLAEHLIPLLPQLLAKFSADAENVAPLLRLLSYFDLNIYCTQRLEKHLELLLQQLQEVVVKHVEPEVLEAAAHALYLLCKPEFTFFSRVDFARSQLVDLLTDRFQQELDDLMQSSFLDEDEVYSLTATLKRLSAFYNAHDLTRWEISEPCSRLLRKAVDTGEVPHQVILPALTLVYFSILWTVTHISESTSQKQLMSLKKRMVAFCELCQSCLSDVDPEIQEQAFVLLSDLLLIFSPQMVVGGRDFLRPLVFFPEATLQSELASFLMDHVFLQPGELGNGQSQEDHVQIELLHQRRRLLAGFCKLLLYGVLELDAASDVFKHYNKFYEDYGDIIKETLTRARQIDRCQCSRILLLSLKQLYTELIQEQGPQDLTELPAFIEMRDLARRFALSFGPQQLHNRDLVVMLHKEGIKFSLSELPPAGSSREPPNIAFLELLSEFSPRLFHQDKQLLLSYLEKCLQRVSMAPSHPWGPVTTYCHSLHLVENTAEASSQGPPHSKKRCIEVPRRLQEEESSSQGESLQLNSGPTTPTLTSTAVKRRQSPRTVGKRQKGGPGPGPGPGPGPGPGPGPGPGPGPGPELICSQQLSGTQRLKMSSAPCFQIRCDPSGSGLGKQMTRLSLMEEDEEEELRLLDEEWQCGDKLLHSPSSPSEHGLDLLDTTELNMEDF
uniprot
proteins
function
FUNCTION: Meiosis specific component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I. {ECO:0000250|UniProtKB:O70576}.
uniprot
proteins
mass_dalton
141951
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250}.
uniprot
proteins
protein_family
SCC3 family
uniprot
proteins
pubmed
11599053
uniprot
proteins
sequence_length
1256
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00750}. Chromosome {ECO:0000250}. Note=Associates with chromatin. In prophase I stage of meiosis, it is found along the axial elements of synaptonemal complexes. In late-pachytene-diplotene, the bulk of protein dissociates from the chromosome arms probably because of phosphorylation by PLK1, except at centromeres, where cohesin complexes remain. It however remains chromatin associated at the centromeres up to metaphase I. During anaphase I, it probably dissociates from centromeres, allowing chromosomes segregation (By similarity). {ECO:0000250}.
uniprot
proteins