Q497V5
uniprot
Q497V5
canonical
amino_acid_sequence
MPSLRKRVKIQAENAEPKDECSFFSELSSGSEEDNKEDSIWEPQKKVPRNRRQPASKGSKRKQGPRAKKSSQQVDDESKDVAVKEELNSPVAIVDADLEEKSHKLQTTKTLKTAAKKQKKPVPRAKKRLKVDEETSQASPLEGGGSNVETPSTSACGNVCKKEESEDSFTFGQSPVKRIRTESCPQGRPARVPDGVSDIKEEVEMNWDVVQVLSERTNIEPWVCANIIRLFNDDNTIPFIVRYRKELINNLDADFLREVRQTLDELRDVAKKVHSRIQKIKKEGKMSECLLQALLNCKTFEELEHVSAPYKMGSKGTKAQRAKQLGLEGAAWTLLENPGQLNLLSYIKPDVKGLSELNDIETGVQHILADMIAKDKDTLDFIRGLCKHRYICIQSSLAKVSSKKVNEKEVDKFQLYQNFSCNIRTIHHHQILAINRGENLKILTVKVNISDGVKNEFCRWCIQNRWRPRGFARPELMKILHNSLDDSFKRLIVPLLCREFRAKLTSDAEKQSVMMFGQNLRQLLLTSPVPGRTLMGVDPGYKHGCKLAIISPTSQILHTDVVYLHCGQGFREAEKIKRLLLHFNCRTVVIGNGTACRETEAYFADLIMKNYFAPLDVVYCIVSEAGASIYSVSPEANKEMPGLDPNLRSAVSIARRVQDPLAELVKFDPKHIGVGMYQHDVSQTLLKATLDSVVEECVSFVGVDINICSEVLLRHIAGLNANRAKNIIEWREKNGPFINREQLKKVKGLGPKSFQQCAGFVRINQDYIRTFCSSQHTDSSGQSQETAMVTNEKLGKKKNKADATLIPNPLDQTCIHPESYDIAVRFLSFIGGTMCEIGKPEMQQKINVSLGKEGIEETAERLQTTVHTLQVIIDGLSQPKTFDIRTDFDKPDFKRSIVCLEDLQVGTVLTGKVENATLFGVFVDIGVGKAGLIPIRFITEAKLSKTKRRRSLGLGPGEKVEVKVLNVDIPRSRISLDLLRVL
uniprot
proteins
function
FUNCTION: DNA- and histone-binding protein that localizes to the central axes of mitotic chromosomes. Promotes chromosome segregation by facilitating TOP2A recruitment to mitotic chromosomes, thereby preventing anaphase failure. During prophase, safeguards the decatenation process to avoid the formation of difficult-to-resolve DNA structures, preventing chromosome missegregation. Also contributes to the regulation of nucleus pulposus cell senescence. {ECO:0000250|UniProtKB:Q8N5C6}.
uniprot
proteins
mass_dalton
110281
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
982
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8N5C6}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q8N5C6}. Cytoplasm {ECO:0000250|UniProtKB:Q8N5C6}. Chromosome {ECO:0000250|UniProtKB:Q8N5C6}.
uniprot
proteins