DENR
entrez
8562
canonical
uniprot
O43583
canonical
ensembl
ENSG00000139726
resolver
ensp
ENSP00000280557
resolver
ensp
ENSP00000633788
resolver
ensp
ENSP00000633789
resolver
ensp
ENSP00000633791
resolver
ensp
ENSP00000633792
resolver
enst
ENST00000280557
resolver
enst
ENST00000963729
resolver
enst
ENST00000963730
resolver
enst
ENST00000963732
resolver
enst
ENST00000963733
resolver
genesymbol
DENR
resolver
genesymbol_syn
DRP1
resolver
hgnc
HGNC:2769
resolver
uniprot
Q9H3U6
resolver
uniprot
Q9UKZ0
resolver
uniprot_entry
DENR_HUMAN
resolver
uniprot_sec
Q9H3U6
resolver
uniprot_sec
Q9UKZ0
resolver
amino_acid_sequence
MAADISESSGADCKGDPRNSAKLDADYPLRVLYCGVCSLPTEYCEYMPDVAKCRQWLEKNFPNEFAKLTVENSPKQEAGISEGQGTAGEEEEKKKQKRGGRGQIKQKKKTVPQKVTIAKIPRAKKKYVTRVCGLATFEIDLKEAQRFFAQKFSCGASVTGEDEIIIQGDFTDDIIDVIQEKWPEVDDDSIEDLGEVKK
uniprot
proteins
function
FUNCTION: Translation regulator forming a complex with MCTS1 to promote translation reinitiation. Translation reinitiation is the process where the small ribosomal subunit remains attached to the mRNA following termination of translation of a regulatory upstream ORF (uORF), and resume scanning on the same mRNA molecule to initiate translation of a downstream ORF, usually the main ORF (mORF). The MCTS1/DENR complex is pivotal to two linked mechanisms essential for translation reinitiation. Firstly, the dissociation of deacylated tRNAs from post-termination 40S ribosomal complexes during ribosome recycling. Secondly, the recruitment in an EIF2-independent manner of aminoacylated initiator tRNA to P site of 40S ribosomes for a new round of translation. This regulatory mechanism governs the translation of more than 150 genes which translation reinitiation is MCTS1/DENR complex-dependent. {ECO:0000269|PubMed:16982740, ECO:0000269|PubMed:20713520, ECO:0000269|PubMed:37875108}.
uniprot
proteins
mass_dalton
22092
uniprot
proteins
protein_family
DENR family
uniprot
proteins
pubmed
10497265
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
16982740
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17878526
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20713520
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
37875108
uniprot
proteins
pubmed
9628587
uniprot
proteins
sequence_length
198
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16982740}.
uniprot
proteins