Ctsg
entrez
290257
canonical
uniprot
P17977
canonical
ensembl
ENSRNOG00000020647
resolver
ensp
ENSRNOP00000056429
resolver
ensp
ENSRNOP00000098990
resolver
enst
ENSRNOT00000059677
resolver
enst
ENSRNOT00000150390
resolver
genesymbol
Ctsg
resolver
uniprot
A0A8I5XFF7
resolver
uniprot
G3V9Q7
resolver
uniprot_entry
A0A8I5XFF7_RAT
resolver
uniprot_entry
CATG_RAT
resolver
uniprot_sec
G3V9Q7
resolver
amino_acid_sequence
MQPLLFLLIFVLFQEDEAGKIIGGREARPNSHPYMAFLLIQSPEGLSACGGFLVREDFVLTAGHCFGSSINVTLGAHNIRRQEGTQQHITVLRAIRHPDYNPPPVIQNDIMLLQLRSRARRSRAVKPVALPQATKRVQPGALCTVAGWGLVSQRRGTNVLQEVKLRVQTDQTCANRFQFYNSQTQICVGNPRERKSAFKGDSGGPLVCNNVAQGIVSYGSSSGNPPAVFTRIQSFMPWIKRTMRRLSSRY
uniprot
proteins
ec_number
3.4.21.20
uniprot
proteins
function
FUNCTION: Serine protease with trypsin- and chymotrypsin-like specificity. Also displays antibacterial activity against Gram-negative and Gram-positive bacteria independent of its protease activity. Prefers Phe and Tyr residues in the P1 position of substrates but also cleaves efficiently after Trp and Leu. Shows a preference for negatively charged amino acids in the P2' position and for aliphatic amino acids both upstream and downstream of the cleavage site. Required for recruitment and activation of platelets which is mediated by the F2RL3/PAR4 platelet receptor. Binds reversibly to and stimulates B cells and CD4(+) and CD8(+) T cells. Also binds reversibly to natural killer (NK) cells and enhances NK cell cytotoxicity through its protease activity. Cleaves complement C3 (By similarity). Cleaves vimentin (By similarity). Cleaves thrombin receptor F2R/PAR1. Cleaves the synovial mucin-type protein PRG4/lubricin. Cleaves and activates IL36G which promotes expression of chemokines CXCL1 and CXLC8 in keratinocytes. Cleaves IL33 into mature forms which have greater activity than the unprocessed form. Cleaves coagulation factor F8 to produce a partially activated form. Also cleaves and activates coagulation factor F10. Cleaves leukocyte cell surface protein SPN/CD43 to release its extracellular domain and trigger its intramembrane proteolysis by gamma-secretase, releasing the CD43 cytoplasmic tail chain (CD43-ct) which translocates to the nucleus. During apoptosis, cleaves SMARCA2/BRM to produce a 160 kDa cleavage product which localizes to the cytosol. Cleaves MBP in B cell lysosomes at '88-Phe-|-Lys-89' and '112-Phe-|-Ser-113', degrading the major immunogenic MBP epitope and preventing the activation of MBP-specific autoreactive T cells. Cleaves annexin ANXA1 and antimicrobial peptide CAMP to produce peptides which act on neutrophil N-formyl peptide receptors to enhance the release of CXCL2. Acts as a ligand for the N-formyl peptide receptor FPR1, enhancing phagocyte chemotaxis. Has antibacterial activity against the Gram-negative bacteria N.gonorrhoeae and P.aeruginosa. Likely to act against N.gonorrhoeae by interacting with N.gonorrhoeae penA/PBP2. Exhibits potent antimicrobial activity against the Gram-positive bacterium L.monocytogenes. Has antibacterial activity against the Gram-positive bacterium S.aureus and degrades S.aureus biofilms, allowing polymorphonuclear leukocytes to penetrate the biofilm and phagocytose bacteria. Has antibacterial activity against M.tuberculosis (By similarity). Induces platelet aggregation which is strongly potentiated in the presence of ELANE (By similarity). {ECO:0000250|UniProtKB:P08311, ECO:0000250|UniProtKB:P28293}.
uniprot
proteins
mass_dalton
27804
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
2222858
uniprot
proteins
sequence_length
250
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P08311}; Peripheral membrane protein {ECO:0000305}. Cytoplasmic granule {ECO:0000250|UniProtKB:P08311}. Secreted {ECO:0000250|UniProtKB:P08311}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P08311}. Lysosome {ECO:0000250|UniProtKB:P08311}. Nucleus {ECO:0000250|UniProtKB:P08311}. Note=Secreted by activated neutrophils. Detected in synovial fluid. Localizes to lysosomes in B cells where it is not endogenously synthesized but is internalized from the cell membrane. Localizes to the nucleus during apoptosis. {ECO:0000250|UniProtKB:P08311}.
uniprot
proteins