Nudt15
entrez
214254
canonical
uniprot
Q8BG93
canonical
ensembl
ENSMUSG00000033405
resolver
ensp
ENSMUSP00000039537
resolver
ensp
ENSMUSP00000206368
resolver
enst
ENSMUST00000043813
resolver
genesymbol
Nudt15
resolver
genesymbol_syn
Mth2
resolver
uniprot_entry
NUD15_MOUSE
resolver
amino_acid_sequence
MAANAEPRRRPGVGVGVVVLSCEHPRCVLLGKRKGSFGAGSFQLPGGHLEFGETWEECAQRETWEEAGLHLKNVCFASVVNSFVEKENYHYVTILMKGEVDMTHDSEPRNMEPEKNESWEWVPWEEFPPLDQLFWALRCLKEQGYDPFKEDLNHLEGYRGEHLERTTKTP
uniprot
proteins
ec_number
3.6.1.68
uniprot
proteins
ec_number
3.6.1.76
uniprot
proteins
ec_number
3.6.1.9
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP (PubMed:12767940). Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives (By similarity). Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear (PubMed:12767940). Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs (By similarity). May also have a role in DNA synthesis and cell cycle progression by stabilizing PCNA (By similarity). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (PubMed:32432673). In vitro, it catalyzes the hydrolysis of isoprene pyrophosphates, including (2E)-geranyl diphosphate, isopentenyl diphosphate, (2E,6E)-farnesyl diphosphate and dimethylallyl diphosphate. It may therefore play a role in the control of cellular levels of these metabolites that are essential for multiple cellular processes, including isoprenoids synthesis and protein isoprenylation (By similarity). {ECO:0000250|UniProtKB:Q9NV35, ECO:0000269|PubMed:12767940, ECO:0000269|PubMed:32432673}.
uniprot
proteins
mass_dalton
19576
uniprot
proteins
protein_family
Nudix hydrolase family
uniprot
proteins
pubmed
12767940
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19735921
uniprot
proteins
pubmed
32432673
uniprot
proteins
pubmed
8810257
uniprot
proteins
sequence_length
170
uniprot
proteins