POU5F1
entrez
5460
canonical
uniprot
Q01860
canonical
ensembl
ENSG00000204531
resolver
ensembl
ENSG00000206454
resolver
ensembl
ENSG00000229094
resolver
ensembl
ENSG00000230336
resolver
ensembl
ENSG00000233911
resolver
ensembl
ENSG00000235068
resolver
ensembl
ENSG00000237582
resolver
ensp
ENSP00000259915
resolver
ensp
ENSP00000389359
resolver
ensp
ENSP00000425083
resolver
ensp
ENSP00000425479
resolver
ensp
ENSP00000475512
resolver
ensp
ENSP00000475880
resolver
enst
ENST00000441888
resolver
enst
ENST00000471529
resolver
enst
ENST00000512818
resolver
enst
ENST00000513407
resolver
enst
ENST00000606567
resolver
genesymbol
POU5F1
resolver
genesymbol_syn
OCT3
resolver
genesymbol_syn
OCT4
resolver
genesymbol_syn
OTF3
resolver
hgnc
HGNC:9221
resolver
uniprot
A0A0K0KMG8
resolver
uniprot
A0A1B1FIV4
resolver
uniprot
A6NCS1
resolver
uniprot
A6NLL8
resolver
uniprot
D2IYK3
resolver
uniprot
D2IYK4
resolver
uniprot
F2Z381
resolver
uniprot
M1S623
resolver
uniprot
P31359
resolver
uniprot
Q15167
resolver
uniprot
Q15168
resolver
uniprot
Q16422
resolver
uniprot
Q5STF3
resolver
uniprot
Q5STF4
resolver
uniprot
U3KQH6
resolver
uniprot_entry
A0A0K0KMG8_HUMAN
resolver
uniprot_entry
A0A1B1FIV4_HUMAN
resolver
uniprot_entry
D2IYK3_HUMAN
resolver
uniprot_entry
F2Z381_HUMAN
resolver
uniprot_entry
M1S623_HUMAN
resolver
uniprot_entry
PO5F1_HUMAN
resolver
uniprot_sec
A6NCS1
resolver
uniprot_sec
A6NLL8
resolver
uniprot_sec
D2IYK4
resolver
uniprot_sec
P31359
resolver
uniprot_sec
Q15167
resolver
uniprot_sec
Q15168
resolver
uniprot_sec
Q16422
resolver
uniprot_sec
Q5STF3
resolver
uniprot_sec
Q5STF4
resolver
uniprot_sec
U3KQH6
resolver
amino_acid_sequence
MAGHLASDFAFSPPPGGGGDGPGGPEPGWVDPRTWLSFQGPPGGPGIGPGVGPGSEVWGIPPCPPPYEFCGGMAYCGPQVGVGLVPQGGLETSQPEGEAGVGVESNSDGASPEPCTVTPGAVKLEKEKLEQNPEESQDIKALQKELEQFAKLLKQKRITLGYTQADVGLTLGVLFGKVFSQTTICRFEALQLSFKNMCKLRPLLQKWVEEADNNENLQEICKAETLVQARKRKRTSIENRVRGNLENLFLQCPKPTLQQISHIAQQLGLEKDVVRVWFCNRRQKGKRSSSDYAQREDFEAAGSPFSGGPVSFPLAPGPHFGTPGYGSPHFTALYSSVPFPEGEAFPPVSVTTLGSPMHSN
uniprot
proteins
function
FUNCTION: Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. {ECO:0000269|PubMed:18035408}.
uniprot
proteins
mass_dalton
38571
uniprot
proteins
post_translational_modification
PTM: Sumoylation enhances the protein stability, DNA binding and transactivation activity. Sumoylation is required for enhanced YES1 expression. {ECO:0000250|UniProtKB:P20263}.; PTM: Ubiquitinated; undergoes 'Lys-63'-linked polyubiquitination by WWP2 leading to proteasomal degradation. {ECO:0000250|UniProtKB:P20263}.; PTM: ERK1/2-mediated phosphorylation at Ser-111 promotes nuclear exclusion and proteasomal degradation. Phosphorylation at Thr-235 and Ser-236 decrease DNA-binding and alters ability to activate transcription. {ECO:0000269|PubMed:22474382, ECO:0000269|PubMed:23024368}.
uniprot
proteins
protein_family
Class-5 subfamily
uniprot
proteins
protein_family
POU transcription factor family
uniprot
proteins
pubmed
1408763
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16229821
uniprot
proteins
pubmed
16702430
uniprot
proteins
pubmed
18035408
uniprot
proteins
pubmed
18191611
uniprot
proteins
pubmed
19274063
uniprot
proteins
pubmed
20604894
uniprot
proteins
pubmed
22474382
uniprot
proteins
pubmed
23024368
uniprot
proteins
pubmed
26687479
uniprot
proteins
pubmed
26769970
uniprot
proteins
pubmed
34342803
uniprot
proteins
pubmed
7908264
uniprot
proteins
pubmed
8567814
uniprot
proteins
sequence_length
360
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Expressed in a diffuse and slightly punctuate pattern. Colocalizes with MAPK8 and MAPK9 in the nucleus. {ECO:0000250|UniProtKB:P20263, ECO:0000269|PubMed:18191611, ECO:0000269|PubMed:19274063, ECO:0000269|PubMed:23024368}.
uniprot
proteins