Rab34
entrez
19376
canonical
uniprot
Q64008
canonical
ensembl
ENSMUSG00000002059
resolver
ensp
ENSMUSP00000002128
resolver
ensp
ENSMUSP00000103958
resolver
enst
ENSMUST00000002128
resolver
enst
ENSMUST00000108322
resolver
genesymbol
Rab34
resolver
genesymbol_syn
Rab39
resolver
genesymbol_syn
Rah
resolver
genesymbol_syn
Rah1
resolver
uniprot
F6UIA8
resolver
uniprot
Q0PD20
resolver
uniprot
Q8BHJ0
resolver
uniprot
Q99P59
resolver
uniprot
Q99P90
resolver
uniprot_entry
F6UIA8_MOUSE
resolver
uniprot_entry
Q0PD20_MOUSE
resolver
uniprot_entry
RAB34_MOUSE
resolver
uniprot_sec
Q8BHJ0
resolver
uniprot_sec
Q99P59
resolver
uniprot_sec
Q99P90
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MNILAPVRRDRVLAELPQCLKKEAALHVRKDFHPRVTCACQEHRTGTVGFKISKVIVVGDLSVGKTCLINRFCKDTFDKNYKATIGVDFEMERFEVLGVPFSLQLWDTAGQERFKCIASTYYRGAQAIIIVFNLNDVASLEHTKQWLTDALKENDPSNVLLFLVGSKKDLSTPAQYSLMEKDALKVAQEIKAEYWAVSSLTGENVREFFFRVAALTFEANVLADVEKSGARHIADVVRINSDDKNLYLTASKKKATCCP
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (By similarity). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB34 transports protein involved in the redistribution of lysosomes to the peri-Golgi region (PubMed:12475955). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (By similarity). Plays a role in the fusion of phagosomes with lysosomes (By similarity). Required for the early steps of intracellular ciliogenesis, the cilium assembly pathway initiated by trafficking and docking of ciliary vesicles to the centrioles in the cytoplasm, followed by axoneme formation in the cytoplasm. After axoneme elongation, the centrioles migrate close to the cell surface so that ciliary vesicles can fuse with the plasma membrane to expose cilia to the extracellular space (PubMed:30301781, PubMed:33989524). It seems dispensable for ciliogenesis via the extracellular pathway where cilium assembly begins after migration and docking of the centriole to the plasma membrane (PubMed:33989524). Also acts as a positive regulator of hedgehog signaling and regulates ciliary function (PubMed:29290584). {ECO:0000250|UniProtKB:P20340, ECO:0000250|UniProtKB:Q9BZG1, ECO:0000269|PubMed:12475955, ECO:0000269|PubMed:29290584, ECO:0000269|PubMed:30301781, ECO:0000269|PubMed:33989524}.
uniprot
proteins
mass_dalton
29101
uniprot
proteins
mutagenesis
MUTAGEN 66; /note="T->N: Fails to rescue loss of ciliogenesis in RAB34-deficient fibroblasts. Does not localize to cilia."; /evidence="ECO:0000269|PubMed:30301781, ECO:0000269|PubMed:33989524"; MUTAGEN 82; /note="K->Q: Abolishes interaction with RILP and localization to the peri-Golgi region."; /evidence="ECO:0000269|PubMed:12475955"; MUTAGEN 82; /note="K->Y: Does not abolish interaction with RILP and localization to the peri-Golgi region."; /evidence="ECO:0000269|PubMed:12475955"; MUTAGEN 111; /note="Q->L: Able to rescue loss of ciliogenesis in RAB34-deficient fibroblasts. Unchanged localization to cilium."; /evidence="ECO:0000269|PubMed:30301781, ECO:0000269|PubMed:33989524"; MUTAGEN 257..258; /note="CC->AA: Fails to rescue loss of ciliogenesis in RAB34-deficient fibroblasts."; /evidence="ECO:0000269|PubMed:33989524
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
12475955
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1752434
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29290584
uniprot
proteins
pubmed
30301781
uniprot
proteins
pubmed
33989524
uniprot
proteins
sequence_length
259
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12475955}. Golgi apparatus {ECO:0000269|PubMed:12475955, ECO:0000269|PubMed:33989524}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q9BZG1}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9BZG1}; Lipid-anchor {ECO:0000250|UniProtKB:Q9BZG1}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9BZG1}. Cell projection, cilium {ECO:0000269|PubMed:29290584, ECO:0000269|PubMed:30301781, ECO:0000269|PubMed:33989524}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q9BZG1}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:33989524}. Note=Recruited to phagosomes containing S.aureus or Mycobacterium. {ECO:0000250|UniProtKB:Q9BZG1}.
uniprot
proteins