Nudt3
entrez
56409
canonical
uniprot
Q9JI46
canonical
ensembl
ENSMUSG00000024213
resolver
ensp
ENSMUSP00000025050
resolver
ensp
ENSMUSP00000110536
resolver
enst
ENSMUST00000025050
resolver
enst
ENSMUST00000114886
resolver
genesymbol
Nudt3
resolver
genesymbol_syn
Dipp
resolver
genesymbol_syn
Dipp1
resolver
uniprot
B2KF67
resolver
uniprot
B2KF68
resolver
uniprot
Q6PG02
resolver
uniprot
Q8BV71
resolver
uniprot_entry
B2KF67_MOUSE
resolver
uniprot_entry
NUDT3_MOUSE
resolver
uniprot_sec
B2KF68
resolver
uniprot_sec
Q6PG02
resolver
uniprot_sec
Q8BV71
resolver
amino_acid_sequence
MMKLKSNQTRTYDGDGYKKRAACLCFRSESEEEVLLVSSSRHPDRWIVPGGGMEPEEEPSVAAVREVCEEAGVKGTLGRLVGIFENQERKHRTYVYVLIVTEVLEDWEDSVNIGRKREWFKIEDAIKVLQCHKPVQASYFETLRQGYPANNGTPVVPTTYSSSVSGIR
uniprot
proteins
ec_number
3.6.1.10
uniprot
proteins
ec_number
3.6.1.52
uniprot
proteins
ec_number
3.6.1.59
uniprot
proteins
ec_number
3.6.1.61
uniprot
proteins
ec_number
3.6.1.62
uniprot
proteins
function
FUNCTION: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction (PubMed:15212765). InsP6 (inositol hexakisphosphate) is not a substrate (By similarity). Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) and diadenosine 5',5'''- P1,P5-pentaphosphate (Ap5A) being the preferred substrates (By similarity). The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A (By similarity). Also able to hydrolyze 5- phosphoribose 1-diphosphate (By similarity). Acts as a negative regulator of the ERK1/2 pathway (PubMed:15212765). Acts as a decapping enzyme that can hydrolyze both monomethylated and unmethylated capped RNAs (PubMed:23353937). Hydrolyzes monomethylated capped RNA after both the alpha- and beta-phosphates generating m7GMP + ppRNA and m7GDP + pRNA (PubMed:23353937). Modulates the stability of a subset of mRNAs implicated in cell motility (By similarity). Divalent cations zinc, magnesium and manganese determine its substrate specificity (By similarity). Exhibits diphosphoinositol polyphosphate phosphohydrolase in the presence of magnesium ions, diadenosine hexaphosphate hydrolase activity in the presence of manganese ions and endopolyphosphatase activity in the presence of zinc ions (By similarity). Plays an important role in limiting DNA damage and maintaining cell survival upon oxidative stress via its endopolyphosphatase activity (By similarity). {ECO:0000250|UniProtKB:O95989, ECO:0000269|PubMed:15212765, ECO:0000269|PubMed:23353937}.
uniprot
proteins
mass_dalton
19030
uniprot
proteins
mutagenesis
MUTAGEN 70; /note="E->Q: Loss of diphosphoinositol polyphosphate phosphohydrolase activity, but retains ability to regulate the ERK1/2 pathway."; /evidence="ECO:0000269|PubMed:15212765
uniprot
proteins
protein_family
DIPP subfamily
uniprot
proteins
protein_family
Nudix hydrolase family
uniprot
proteins
pubmed
15212765
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23353937
uniprot
proteins
sequence_length
168
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O95989}. Nucleus {ECO:0000250|UniProtKB:O95989}.
uniprot
proteins