PLA1A
entrez
51365
canonical
uniprot
Q53H76
canonical
ensembl
ENSG00000144837
resolver
ensp
ENSP00000273371
resolver
ensp
ENSP00000417326
resolver
ensp
ENSP00000418793
resolver
ensp
ENSP00000420625
resolver
enst
ENST00000494440
resolver
genesymbol
PLA1A
resolver
genesymbol_syn
NMD
resolver
genesymbol_syn
PSPLA1
resolver
hgnc
HGNC:17661
resolver
uniprot
B2R8V2
resolver
uniprot
B4DXA2
resolver
uniprot
G5E9W0
resolver
uniprot
O95991
resolver
uniprot
Q86WX6
resolver
uniprot
Q9UPD2
resolver
uniprot_entry
G5E9W0_HUMAN
resolver
uniprot_entry
PLA1A_HUMAN
resolver
uniprot_sec
B2R8V2
resolver
uniprot_sec
B4DXA2
resolver
uniprot_sec
O95991
resolver
uniprot_sec
Q86WX6
resolver
uniprot_sec
Q9UPD2
resolver
amino_acid_sequence
MPPGPWESCFWVGGLILWLSVGSSGDAPPTPQPKCADFQSANLFEGTDLKVQFLLFVPSNPSCGQLVEGSSDLQNSGFNATLGTKLIIHGFRVLGTKPSWIDTFIRTLLRATNANVIAVDWIYGSTGVYFSAVKNVIKLSLEISLFLNKLLVLGVSESSIHIIGVSLGAHVGGMVGQLFGGQLGQITGLDPAGPEYTRASVEERLDAGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGGQDQPGCPTFFYAGYSYLICDHMRAVHLYISALENSCPLMAFPCASYKAFLAGRCLDCFNPFLLSCPRIGLVEQGGVKIEPLPKEVKVYLLTTSSAPYCMHHSLVEFHLKELRNKDTNIEVTFLSSNITSSSKITIPKQQRYGKGIIAHATPQCQINQVKFKFQSSNRVWKKDRTTIIGKFCTALLPVNDREKMVCLPEPVNLQASVTVSCDLKIACV
uniprot
proteins
ec_number
3.1.1.111
uniprot
proteins
function
FUNCTION: Hydrolyzes the ester bond of the acyl group attached at the sn-1 position of phosphatidylserines (phospholipase A1 activity) and 1-acyl-2-lysophosphatidylserines (lysophospholipase activity) in the pathway of phosphatidylserines acyl chain remodeling (PubMed:10196188). Cleaves phosphatidylserines exposed on the outer leaflet of the plasma membrane of apoptotic cells producing 2-acyl-1-lysophosphatidylserines, which in turn enhance mast cell activation and histamine production (By similarity). Has no activity toward other glycerophospholipids including phosphatidylcholines, phosphatidylethanolamines, phosphatidic acids or phosphatidylinositols, or glycerolipids such as triolein (By similarity). {ECO:0000250|UniProtKB:P97535, ECO:0000269|PubMed:10196188}.; FUNCTION: [Isoform 2]: Hydrolyzes lyso-PS but not PS. {ECO:0000269|PubMed:10196188}.
uniprot
proteins
mass_dalton
49715
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
protein_family
Lipase family
uniprot
proteins
pubmed
10196188
uniprot
proteins
pubmed
12436198
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
9074642
uniprot
proteins
sequence_length
456
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P97535}.
uniprot
proteins