Tbxas1
entrez
24886
canonical
uniprot
P49430
canonical
ensembl
ENSRNOG00000007918
resolver
ensembl
ENSRNOG00055030925
resolver
ensembl
ENSRNOG00060008792
resolver
ensembl
ENSRNOG00065016795
resolver
ensp
ENSRNOP00000010796
resolver
ensp
ENSRNOP00055044397
resolver
ensp
ENSRNOP00060011374
resolver
ensp
ENSRNOP00065022159
resolver
enst
ENSRNOT00000010796
resolver
enst
ENSRNOT00055053673
resolver
enst
ENSRNOT00060014722
resolver
enst
ENSRNOT00065028043
resolver
genesymbol
Tbxas1
resolver
genesymbol_syn
Cyp5
resolver
genesymbol_syn
Cyp5a1
resolver
uniprot_entry
THAS_RAT
resolver
amino_acid_sequence
MEVLGLLKFEVSGTVVTVTLSVVLLALLKWYSTSAFSRLRKLGIRHPEPSPFVGNLMFFRQGFWESHLELRERYGPLCGYYLGRRMYIVISDPDMIKEVLVENFSNFSNRMASGLEPKLIADSVLMLRDRRWEEVRGALMSAFSPEKLNEMTPLISQACELLLSHLKHSAASGDAFDIQRCYCCFTTNVVASVAFGIEVNSQDAPEDPFVQHCQRVFAFSTPRPLLALILSFPSIMVPLARILPNKNRDELNGFFNTLIRNVIALRDKQTAEERRGDFLQMVLDAQRSMSSVGVEAFDMVTEALSSAECMGDPPQRCHPTSTAKPLTVDEIAGQAFLFLIAGHEITTNTLSFITYLLATHPECQERLLKEVDLFMEKHPAPEYCNLQEGLPYLDMVVAETLRMYPPAFRFTREAAQDCEVLGQHIPAGSVLEIAVGALHHDPEHWPNPETFDPERFTAEARLQQKPFTYLPFGAGPRSCLGVRLGLLVVKLTLLQVLHKFRFEACPETQVPLQLESKSALCPKNGVYVKIVSR
uniprot
proteins
ec_number
4.2.1.152
uniprot
proteins
ec_number
5.3.99.5
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of prostaglandin H2 (PGH2) to thromboxane A2 (TXA2), a potent inducer of blood vessel constriction and platelet aggregation. Also cleaves PGH2 to 12-hydroxy-heptadecatrienoicacid (12-HHT) and malondialdehyde, which is known to act as a mediator of DNA damage. 12-HHT and malondialdehyde are formed stoichiometrically in the same amounts as TXA2. Additionally, displays dehydratase activity, toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE) producing 15-KETE and 15-HETE. {ECO:0000250|UniProtKB:P24557}.
uniprot
proteins
mass_dalton
59974
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
8131852
uniprot
proteins
pubmed
9261862
uniprot
proteins
sequence_length
533
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P24557}; Multi-pass membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 11..31; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 76..96; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 224..244; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 336..356; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins