Chchd3
entrez
66075
canonical
uniprot
Q9CRB9
canonical
ensembl
ENSMUSG00000053768
resolver
ensp
ENSMUSP00000070149
resolver
ensp
ENSMUSP00000123220
resolver
ensp
ENSMUSP00000260585
resolver
ensp
ENSMUSP00000328354
resolver
enst
ENSMUST00000066379
resolver
genesymbol
Chchd3
resolver
genesymbol_syn
Mic19
resolver
uniprot_entry
MIC19_MOUSE
resolver
amino_acid_sequence
MGGTASTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSSVYGASVSDEDLKRRVAEELALEQAKKESEHQRRLKQARDLERERAAANEQLTRAVLRERISSEEERMKAKHLARQLEEKDRVMRKQDAFYKEQLARLEERSSEFYKVTTEEYQKAAEEVEAKFKRYEYHPVCADLQTKILQCYRQNTQQTLSCSALASQYMHCVNHAKQSMLEKGG
uniprot
proteins
function
FUNCTION: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Has also been shown to function as a transcription factor which binds to the BAG1 promoter and represses BAG1 transcription. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology. {ECO:0000250|UniProtKB:Q9NX63, ECO:0000269|PubMed:21081504}.
uniprot
proteins
mass_dalton
26335
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="G->A: Loss of SAMM50-binding. Reduced affinity toward OPA1. No effect on IMMT-binding."; /evidence="ECO:0000269|PubMed:21081504
uniprot
proteins
protein_family
MICOS complex subunit Mic19 family
uniprot
proteins
protein_family
Metazoan Mic19 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21081504
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
227
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:21081504}; Lipid-anchor {ECO:0000269|PubMed:21081504}; Intermembrane side {ECO:0000269|PubMed:21081504}. Cytoplasm {ECO:0000250|UniProtKB:Q9NX63}. Nucleus {ECO:0000250|UniProtKB:Q9NX63}. Mitochondrion {ECO:0000250|UniProtKB:Q9NX63}.
uniprot
proteins