STAC2
entrez
342667
canonical
uniprot
Q6ZMT1
canonical
ensembl
ENSG00000141750
resolver
ensp
ENSP00000327509
resolver
ensp
ENSP00000595608
resolver
ensp
ENSP00000615484
resolver
genesymbol
STAC2
resolver
hgnc
HGNC:23990
resolver
uniprot
D0IN09
resolver
uniprot
Q32MA3
resolver
uniprot_entry
D0IN09_HUMAN
resolver
uniprot_entry
STAC2_HUMAN
resolver
uniprot_sec
Q32MA3
resolver
amino_acid_sequence
MTEMSEKENEPDDAATHSPPGTVSALQETKLQRFKRSLSLKTILRSKSLENFFLRSGSELKCPTEVLLTPPTPLPPPSPPPTASDRGLATPSPSPCPVPRPLAALKPVRLHSFQEHVFKRASPCELCHQLIVGNSKQGLRCKMCKVSVHLWCSEEISHQQCPGKTSTSFRRNFSSPLLVHEPPPVCATSKESPPTGDSGKVDPVYETLRYGTSLALMNRSSFSSTSESPTRSLSERDELTEDGEGSIRSSEEGPGDSASPVFTAPAESEGPGPEEKSPGQQLPKATLRKDVGPMYSYVALYKFLPQENNDLALQPGDRIMLVDDSNEDWWKGKIGDRVGFFPANFVQRVRPGENVWRCCQPFSGNKEQGYMSLKENQICVGVGRSKDADGFIRVSSGKKRGLVPVDALTEI
uniprot
proteins
function
FUNCTION: Plays a redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C. Negative regulator of osteoclastogenesis. Following TNFSF11/RANKL stimulation, interacts with TNFRSF11A/RANK and interferes with the formation of the TNFRSF11A signaling complex, leading to the suppression of TNFSF11-initiated NF-kappa-B and MAPK signaling pathways. Impairs TNFSF11-induced, BTK/TEC-catalyzed PLCG2 phosphorylation and activation (By similarity). {ECO:0000250|UniProtKB:Q8R1B0}.
uniprot
proteins
mass_dalton
45009
uniprot
proteins
mutagenesis
MUTAGEN 306; /note="Q->L: Mildly decreased affinity for CACNA1S."; /evidence="ECO:0000269|PubMed:29078335"; MUTAGEN 329; /note="W->S: Loss of interaction with CACNA1S."; /evidence="ECO:0000269|PubMed:29078335"; MUTAGEN 347; /note="Q->I: No effect on the structure of the two SH3 domains."; /evidence="ECO:0000269|PubMed:29078335
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
29078335
uniprot
proteins
sequence_length
411
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8R1B0}. Cell membrane {ECO:0000250|UniProtKB:Q8R1B0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8R1B0}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8R1B0}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:Q8R1B0}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8R1B0}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8R1B0}. Membrane raft {ECO:0000250|UniProtKB:Q8R1B0}. Note=Colocalizes with CACNA1C at the plasma membrane of transfected cells. Following TNFSF11/RANKL stimulation, recruited to lipid rafts along with TNFRSF11A/RANK (By similarity). {ECO:0000250|UniProtKB:Q8R1B0}.
uniprot
proteins