Slc18a3
entrez
60422
canonical
uniprot
Q62666
canonical
genesymbol
Slc18a3
resolver
genesymbol_syn
Vacht
resolver
genesymbol_syn
Vat
resolver
uniprot
Q64351
resolver
uniprot_entry
VACHT_RAT
resolver
uniprot_sec
Q64351
resolver
activity_regulation
ACTIVITY REGULATION: Potently inhibited by L-vesamicol. {ECO:0000269|PubMed:15485505, ECO:0000269|PubMed:8071310}.
uniprot
proteins
amino_acid_sequence
MEPTAPTGQARAAATKLSEAVGAALQEPQRQRRLVLVIVCVALLLDNMLYMVIVPIVPDYIAHMRGGSEGPTLVSEVWEPTLPPPTLANASAYLANTSASPTAAGSARSILRPRYPTESEDVKIGVLFASKAILQLLVNPLSGPFIDRMSYDVPLLIGLGVMFASTVMFAFAEDYATLFAARSLQGLGSAFADTSGIAMIADKYPEEPERSRALGVALAFISFGSLVAPPFGGILYEFAGKRVPFLVLAAVSLFDALLLLAVAKPFSAAARARANLPVGTPIHRLMLDPYIAVVAGALTTCNIPLAFLEPTIATWMKHTMAASEWEMGMVWLPAFVPHVLGVYLTVRLAARYPHLQWLYGALGLAVIGVSSCVVPACRSFAPLVVSLCGLCFGIALVDTALLPTLAFLVDVRHVSVYGSVYAIADISYSVAYALGPIVAGHIVHSLGFEQLSLGMGLANLLYAPVLLLLRNVGLLTRSRSERDVLLDEPPQGLYDAVRLREVQGKDGGEPCSPPGPFDGCEDDYNYYSRS
uniprot
proteins
function
FUNCTION: Electrogenic antiporter that exchanges one cholinergic neurotransmitter, acetylcholine or choline, with two intravesicular protons across the membrane of synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to store neurotransmitters inside the vesicles prior to their release via exocytosis (PubMed:15485505, PubMed:8071310). Determines cholinergic vesicular quantal size at presynaptic nerve terminals in developing neuro-muscular junctions with an impact on motor neuron differentiation and innervation pattern (PubMed:9182805). Part of forebrain cholinergic system, regulates hippocampal synapse transmissions that underlie spatial memory formation (By similarity). Can transport serotonin. {ECO:0000250|UniProtKB:O35304, ECO:0000250|UniProtKB:Q16572, ECO:0000269|PubMed:15485505, ECO:0000269|PubMed:8071310, ECO:0000269|PubMed:9182805}.
uniprot
proteins
mass_dalton
56537
uniprot
proteins
mutagenesis
MUTAGEN 193; /note="D->N: Loss of activity."; /evidence="ECO:0000269|PubMed:9182805"; MUTAGEN 398; /note="D->N: Loss of activity."; /evidence="ECO:0000269|PubMed:9182805
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Vesicular transporter family
uniprot
proteins
pubmed
15485505
uniprot
proteins
pubmed
7938002
uniprot
proteins
pubmed
8071310
uniprot
proteins
pubmed
8071313
uniprot
proteins
pubmed
9182805
uniprot
proteins
sequence_length
530
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:9182805}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..54; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 126..146; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 153..173; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 183..203; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 214..234; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 243..263; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 290..310; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 326..346; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 357..377; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 389..409; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 423..443; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 448..468; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins