EIF3I
entrez
8668
canonical
uniprot
Q13347
canonical
ensembl
ENSG00000084623
resolver
ensp
ENSP00000502867
resolver
ensp
ENSP00000503348
resolver
ensp
ENSP00000503539
resolver
ensp
ENSP00000503706
resolver
ensp
ENSP00000504034
resolver
ensp
ENSP00000504061
resolver
enst
ENST00000676801
resolver
enst
ENST00000677202
resolver
enst
ENST00000677701
resolver
enst
ENST00000677711
resolver
enst
ENST00000677760
resolver
enst
ENST00000678063
resolver
genesymbol
EIF3I
resolver
genesymbol
EIF3S2
resolver
genesymbol_syn
EIF3I
resolver
genesymbol_syn
EIF3S2
resolver
genesymbol_syn
TRIP1
resolver
hgnc
HGNC:3272
resolver
uniprot
A0A7I2YQI2
resolver
uniprot
Q5U0F4
resolver
uniprot_entry
A0A7I2YQI2_HUMAN
resolver
uniprot_entry
EIF3I_HUMAN
resolver
uniprot_entry
Q5U0F4_HUMAN
resolver
amino_acid_sequence
MKPILLQGHERSITQIKYNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCRLWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQIDNNEPYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSRDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSAALSPNYDHVVLGGGQEAMDVTTTSTRIGKFEARFFHLAFEEEFGRVKGHFGPINSVAFHPDGKSYSSGGEDGYVRIHYFDPQYFEFEFEA
uniprot
proteins
function
FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773). {ECO:0000255|HAMAP-Rule:MF_03008, ECO:0000269|PubMed:17581632, ECO:0000269|PubMed:25849773, ECO:0000269|PubMed:27462815}.
uniprot
proteins
mass_dalton
36502
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by TGF-beta type II receptor. {ECO:0000255|HAMAP-Rule:MF_03008}.
uniprot
proteins
protein_family
EIF-3 subunit I family
uniprot
proteins
pubmed
14519125
uniprot
proteins
pubmed
14688252
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15703437
uniprot
proteins
pubmed
16322461
uniprot
proteins
pubmed
16766523
uniprot
proteins
pubmed
17322308
uniprot
proteins
pubmed
17581632
uniprot
proteins
pubmed
18599441
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25849773
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27462815
uniprot
proteins
pubmed
7566156
uniprot
proteins
pubmed
8995409
uniprot
proteins
sequence_length
325
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03008}.
uniprot
proteins