Heyl
entrez
56198
canonical
uniprot
Q9DBX7
canonical
ensembl
ENSMUSG00000032744
resolver
ensp
ENSMUSP00000040576
resolver
enst
ENSMUST00000040821
resolver
genesymbol
Heyl
resolver
genesymbol_syn
Hesr3
resolver
genesymbol_syn
Hrt3
resolver
uniprot
Q9JJV6
resolver
uniprot
Q9QXW8
resolver
uniprot_entry
HEYL_MOUSE
resolver
uniprot_sec
Q9JJV6
resolver
uniprot_sec
Q9QXW8
resolver
amino_acid_sequence
MKRPRAPSGSDGESDGPIDVGQENDLSQMARPLTTPSPSQMQARKKRRGIIEKRRRDRINSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHASGGTGFFDARALAVDFRSIGFRECLTEVIRYLGVLEGPSSHADPVRIRLLSHLKSYAAEMEPSPTTTSALAFPVWPWSFLHSCPGLPSLNSQLAILGRVPGPVLPSISSPPYPISALRSAPVHRPAGTIPPTRRNLLPSRGVTSTQRAHLPERPAAPPPTALDARAARSIVPIPPCSPTTAPGAGKSDDNVSGSISSPCPSGPTGRPAGAVFYHSWVSEITEIGAF
uniprot
proteins
function
FUNCTION: Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (By similarity). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6. {ECO:0000250, ECO:0000269|PubMed:16199874, ECO:0000269|PubMed:17303760}.
uniprot
proteins
mass_dalton
34929
uniprot
proteins
protein_family
HEY family
uniprot
proteins
pubmed
10588864
uniprot
proteins
pubmed
10860664
uniprot
proteins
pubmed
11044625
uniprot
proteins
pubmed
11160397
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16199874
uniprot
proteins
pubmed
17303760
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
326
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00380, ECO:0000255|PROSITE-ProRule:PRU00981}.
uniprot
proteins