Kcns2
entrez
16539
canonical
uniprot
O35174
canonical
ensembl
ENSMUSG00000050963
resolver
ensp
ENSMUSP00000072645
resolver
ensp
ENSMUSP00000153984
resolver
enst
ENSMUST00000072868
resolver
enst
ENSMUST00000228725
resolver
genesymbol
Kcns2
resolver
genesymbol_syn
mKIAA1144
resolver
uniprot
Q543P3
resolver
uniprot
Q69ZQ8
resolver
uniprot_entry
KCNS2_MOUSE
resolver
uniprot_entry
Q69ZQ8_MOUSE
resolver
uniprot_sec
Q543P3
resolver
amino_acid_sequence
MTRQSLWDVSDTDVEDGEIRINVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPELFPYVLHFYHTGKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDEQSDQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWLALDNPGYSVLSRVFSVLSILVVLGSIITMCLNSLPDFQIPDSQGNPGEDPRFEIVEHFGIAWFTFELVARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESSPTLANLGRVAQVLRLMRIFRILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIEKEENEGLATIPACWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYRRQKQLESAMRSCDFGDGMKEVPSVNLRDYYAHKVKSLMASLTNMSRSSPSELSLDDSLH
uniprot
proteins
function
FUNCTION: Potassium channel regulatory subunit that modulate the delayed rectifier voltage-gated potassium channel activity of KCNB1 and KCNB2 by altering their kinetics, expression levels, and shifting the half-inactivation potential to more polarized values (PubMed:9305895). While it does not form functional channels on its own, it can form functional heterotetrameric channels with KCNB1 and KCNB2 (PubMed:9305895). Each regulatory subunit has unique regulatory properties that can lead to extensive inhibition, significant changes in kinetics, and/or substantial shifts in the voltage dependencies of the inactivation process (PubMed:9305895). {ECO:0000269|PubMed:9305895}.
uniprot
proteins
mass_dalton
54289
uniprot
proteins
protein_family
Kv9.2/KCNS2 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
protein_family
S (TC 1.A.1.2) subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
9305895
uniprot
proteins
sequence_length
477
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:9305895}; Multi-pass membrane protein {ECO:0000305}. Note=May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 or KCNB2 (PubMed:9305895). {ECO:0000269|PubMed:9305895}.
uniprot
proteins
transmembrane_region
TRANSMEM 185..206; /note="Helical; Name=Segment S1"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 226..248; /note="Helical; Name=Segment S2"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 260..280; /note="Helical; Name=Segment S3"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 291..311; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 327..348; /note="Helical; Name=Segment S5"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 389..417; /note="Helical; Name=Segment S6"; /evidence="ECO:0000250|UniProtKB:P63142
uniprot
proteins