Synpo2
entrez
118449
canonical
uniprot
Q91YE8
canonical
ensembl
ENSMUSG00000050315
resolver
ensp
ENSMUSP00000051570
resolver
ensp
ENSMUSP00000102034
resolver
ensp
ENSMUSP00000142508
resolver
enst
ENSMUST00000051443
resolver
enst
ENSMUST00000106426
resolver
genesymbol
Synpo2
resolver
uniprot
A0A498WGE8
resolver
uniprot
E9Q1U2
resolver
uniprot
Q8C592
resolver
uniprot_entry
A0A498WGE8_MOUSE
resolver
uniprot_entry
E9Q1U2_MOUSE
resolver
uniprot_entry
SYNP2_MOUSE
resolver
uniprot_sec
Q8C592
resolver
amino_acid_sequence
MGTGDFICISMTGGAPWGFRLQGGKEEQQPLQVAKIRSQSKASGSGLREGDEVVSINGNPCADLTYPEVIKLMEGITDSLHLLVKRPSSGTSETLDSESETTNHQHLTHEGPMESTTLQIQQATETQSEDFFLAPVQTKVPLTEDQSNAWGYAECPKEEQAPPMLGSQEGHLVEEVILRQKAEAGQPGHVVELQLSLSKERHQCTSGPIVTLQGNDKSTSPDPDWSSQLERTVHINSIPAPEKADTSLTSSTSSGRELRVIQGRDPGGAGLPQVEVILDCSDRLKAEECRLQTGRGCVASPVEGGRSEAPPSLVSFAVSSEGTEHGEDQRSGKDQSRPHKHRARHARLRRSESLSEKQVKEAKSKCKSIALLLTDAPNPNSKGVLMFKKRRRRARKYTLVSYGTGELEREEEEEEDQEAGDKDEISEVAFLGTSESEVDEELLSDVDDNTQVVNFDWDSGLVDIEKRLNRGDKMEMLPDTTGKGALMFAKRRERMEQFTAQNEEEKTGGMAGGGPDALQTDGLRTMTSYQRKEESVRMQSSVSESSFQMGRSLASVPQQNGFSGVSETAGAQRMFPMNRTAKPFLGSMNQPAAPFSPTRSVTSPISDFPAPPPYSAVSPPPEAFSRGVSSPVAGPAQPPPWPQPAPWSQPAFYDSSEQIASRDERIAVPAKRTGILQEAKRRGTTKPMFTFKETKVSPNPELLSLLQNAEGKRGTGGDSGPEEDYLSLGAEACNFMQSSAKQKTPPPVAPKPAVKSPSSSQPVAPVSPVWSPGVAPAQRPAFSTSNPPNPPQVTAVSSIKIAQPAAPPARPASALNLAGPFKGPQAVVVSHNYTPKPSAPTPLVNAAPAGAGGPSNELPGMSGKGAQLFAKRQSRMEKYVVDSDTVQAHTVRAQSPTPSLPASWKYSSNVRAPPPVAYNPIHSPSYPLAAIKSQPPGAQASKTSKKKGKKPLNTLDVMKHQPYQLNASLFTFQPPDSKDGLPQKSTVKVSSAPAMKQALPPRQANVGSPTNAQASSVYSVPAYTSQPNFFAAEATSPVSASPVPVSVPTSPKQESTSTSYFVAPRPKFSAKKSGVTVQVWKPSVVEE
uniprot
proteins
function
FUNCTION: Has an actin-binding and actin-bundling activity (PubMed:11673475). Can induce the formation of F-actin networks. At the sarcomeric Z lines is proposed to act as adapter protein that links nascent myofibers to the sarcolemma via ZYX and may play a role in early assembly and stabilization of the Z lines. Involved in autophagosome formation. May play a role in chaperone-assisted selective autophagy (CASA) involved in Z lines maintenance in striated muscle under mechanical tension; may link the client-processing CASA chaperone machinery to a membrane-tethering and fusion complex providing autophagosome membranes. Involved in regulation of cell migration. May be a tumor suppressor (By similarity). {ECO:0000250|UniProtKB:D4A702, ECO:0000250|UniProtKB:Q9UMS6, ECO:0000269|PubMed:11673475}.
uniprot
proteins
mass_dalton
116527
uniprot
proteins
mutagenesis
MUTAGEN 555; /note="S->A: Impairs interaction with YWHAB."; /evidence="ECO:0000269|PubMed:15883195"; MUTAGEN 602; /note="T->A: Impairs interaction with YWHAB."; /evidence="ECO:0000269|PubMed:15883195
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKA, and by CaMK2 at multiple sites. Dephosphorylated by calcineurin at Ser-555 and Thr-602; abrogating interaction with YWHAB and impairing nuclear import. {ECO:0000269|PubMed:17923693}.
uniprot
proteins
protein_family
Synaptopodin family
uniprot
proteins
pubmed
11673475
uniprot
proteins
pubmed
15883195
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16309678
uniprot
proteins
pubmed
17923693
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1087
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11673475, ECO:0000269|PubMed:16309678, ECO:0000269|PubMed:17923693}. Cytoplasm {ECO:0000269|PubMed:11673475, ECO:0000269|PubMed:17923693}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:11673475}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q9UMS6}. Note=Shuttles between the nucleus and the cytoplasm in a differentiation-dependent and stress-induced fashion. In undifferentiated myoblasts strongly expressed in the nucleus, after induction of myotube differentiation is located to both nucleus and cytoplasm along acting filaments, and in differentiated myotubes is located at the Z lines. Upon stress redistributes from cytoplasm of myoblasts and myotubes to the nucleus. Nuclear import is KPNA2-dependent and promoted by phosphorylation by PKA and/or CaMK2, and inhibition of calcineurin. The nuclear export is XPO1-dependent (PubMed:11673475, PubMed:15883195, PubMed:17923693). {ECO:0000250|UniProtKB:Q9UMS6, ECO:0000269|PubMed:11673475, ECO:0000269|PubMed:17923693}.
uniprot
proteins