Enpp3
entrez
54410
canonical
uniprot
P97675
canonical
ensembl
ENSRNOG00000013791
resolver
ensp
ENSRNOP00000018695
resolver
genesymbol
Enpp3
resolver
genesymbol_syn
Npp3
resolver
genesymbol_syn
Pdnp3
resolver
uniprot
P70641
resolver
uniprot
P97676
resolver
uniprot
Q4V8L6
resolver
uniprot
Q63490
resolver
uniprot_entry
ENPP3_RAT
resolver
uniprot_sec
P70641
resolver
uniprot_sec
P97676
resolver
uniprot_sec
Q4V8L6
resolver
uniprot_sec
Q63490
resolver
amino_acid_sequence
MDSRLALATEEPIKKDSLKRYKILCAVLLALLVIVSLGLGLGLGLRKPEEHIGSCRKKCFDSSHRGLEGCRCDSGCTDRGDCCWDFEDTCVKSTQIWTCNSFRCGETRLEAALCSCADDCLQRKDCCTDYKAVCQGEVPWVTEACASSQEPQCPEGFDQPPVILFSMDGFRAEYLQTWSTLLPNINKLKTCGLHSKYMRAMYPTKTFPNHYTIVTGLYPESHGIIDNNMYDVYLNKNFSLSSVEKSNPAWWSGQPIWLTAMYQGLKAASYYWPGSDVAVNGSFPNIYRNYSNSVPYESRIATLLQWLDLPKAERPSFYTIYVEEPDSAGHKSGPVSAGVIKALQLVDDAFGMLMEGLKQRNLHNCVNIIVLADHGMDQTSCDRVEYMTDYFPEINFYMYQGPAPRIRTRNIPQDFFTFNSEEIVRDLSCRKSDQHFKPYLTPDLPKRLHYAKNVRIDKVHLMVDRQWLAYRNKGSSNCEGGTHGYNNEFKSMEAIFLAHGPSFKEKTVIEPFENIEVYNLLCDLLHIQPAPNNGSHGSLNHLLKAPFYQPSHAEELSKSAGCGFTTPLPKDSLNCSCLALQTSGQEEQVNQRLNLSGGEVSATEKTNLPFGRPRVIQKNKDHCLLYHREYVSGFGKAMKMPMWSSYTVPKPGDTSSLPPTVPDCLRADVRVDPSESQKCSFYLADQNIDHGFLYPPAIKGNNESQYDALITSNLVPMYKEFKKMWDYFHKVLLIKYAIERNGVNVVSGPIFDYNYDGHFDAPDEITNYVAGTDVPVPTHYFVVLTSCKNKTHTPDSCPGWLDVLPFVVPHRPTNVESCPENKAEDLWVEERFKAHIARVRDVELLTGLDFYQEKTQPVSEILQLKTYLPTFETII
uniprot
proteins
ec_number
3.1.4.1
uniprot
proteins
ec_number
3.6.1.-
uniprot
proteins
ec_number
3.6.1.9
uniprot
proteins
function
FUNCTION: Hydrolase that metabolizes extracellular nucleotides, including ATP, GTP, UTP and CTP (By similarity). Also hydrolyzes extracellular 2',3'-cGAMP (cyclic GMP-AMP), a second messenger that activates TMEM173/STING and triggers type-I interferon production, and is therefore involved in the regulation of innate immune response (By similarity). 2',3'-cGAMP appears to be further processed to GMP, AMP and inorganic phosphate (By similarity). Limits mast cells and basophils response during inflammation and during the chronic phases of allergic responses by eliminating extracellular ATP, a signaling molecule activating these cells in an autocrine manner. Metabolizes extracellular ATP in the lumen of the small intestine, and thereby prevents ATP-induced apoptosis of intestinal plasmacytoid dendritic cells (By similarity). Has a broad specificity and can also hydrolyze UDP-GlcNAc into UMP and GlcNAc-1-phosphate and potentially several other intracellular nucleotide sugars, including UDP-GalNAc, CMP-NeuAc, GDP-Fuc, and UDP-GlcA. Thereby, could modulate glycan biosynthesis and protein glycosylation (By similarity). Can hydrolyze extracellular dinucleoside polyphosphates, including the vasoactive adenosine polyphosphates as well. In addition, displays an alkaline phosphodiesterase activity in vitro (PubMed:9096610). {ECO:0000250|UniProtKB:O14638, ECO:0000250|UniProtKB:Q6DYE8, ECO:0000269|PubMed:9096610}.
uniprot
proteins
mass_dalton
99072
uniprot
proteins
post_translational_modification
PTM: The N-terminal is blocked.; PTM: N-glycosylated (PubMed:7730366, PubMed:9096610). N-glycosylation is necessary for normal transport to the cell membrane, but is not the apical targeting signal (PubMed:11069764). {ECO:0000269|PubMed:11069764, ECO:0000269|PubMed:7730366, ECO:0000269|PubMed:9096610}.
uniprot
proteins
protein_family
Nucleotide pyrophosphatase/phosphodiesterase family
uniprot
proteins
pubmed
11069764
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7730366
uniprot
proteins
pubmed
9096610
uniprot
proteins
sequence_length
875
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7730366}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O14638}. Apical cell membrane {ECO:0000269|PubMed:11069764, ECO:0000269|PubMed:9096610}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O14638}. Secreted {ECO:0000250|UniProtKB:O14638}. Note=Detected at the cell surface of basophils. Detected at the apical plasma membrane of bile duct cells. Located to the apical surface in intestinal and kidney epithelial cells. Secreted in serum, and in lumen of epithelial cells. {ECO:0000250|UniProtKB:O14638}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..30; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins