Slc6a18
entrez
22598
canonical
uniprot
O88576
canonical
ensembl
ENSMUSG00000021612
resolver
ensp
ENSMUSP00000022105
resolver
ensp
ENSMUSP00000105301
resolver
ensp
ENSMUSP00000105302
resolver
ensp
ENSMUSP00000152146
resolver
ensp
ENSMUSP00000152403
resolver
ensp
ENSMUSP00000152525
resolver
enst
ENSMUST00000022105
resolver
genesymbol
Slc6a18
resolver
genesymbol_syn
B0at3
resolver
genesymbol_syn
Xt2
resolver
genesymbol_syn
Xtrp2
resolver
uniprot
A0A217FL56
resolver
uniprot
O88577
resolver
uniprot
O88578
resolver
uniprot
O88579
resolver
uniprot
O88580
resolver
uniprot
O88581
resolver
uniprot
Q91XG6
resolver
uniprot_entry
A0A217FL56_MOUSE
resolver
uniprot_entry
S6A18_MOUSE
resolver
uniprot_sec
O88577
resolver
uniprot_sec
O88578
resolver
uniprot_sec
O88579
resolver
uniprot_sec
O88580
resolver
uniprot_sec
O88581
resolver
uniprot_sec
Q91XG6
resolver
amino_acid_sequence
MAQASGMDPLVDIEDERPKWDNKLQYLLSCIGFAVGLGNIWRFPYLCQTHGGGAFLIPYFIALVFEGIPLFYIELAIGQRLRRGSIGVWKTISPYLGGVGLGCFSVSFLVSLYYNTVLLWVLWFFLNSFQHPLPWSTCPLDLNRTGFVQECQSSGTVSYFWYRQTLNITSDISNTGTIQWKLFLCLVACWSTVYLCVIRGIESTGKVIYFTALFPYLVLTIFLIRGLTLPGATEGLIYLFTPNMKTLQNPRVWLDAATQIFFSLSLAFGGHIAFASYNPPRNNCEKDAVIIALVNSMTSLYASIAIFSVMGFKASNDYGRCLDRNILSLINEFDLPELSISRDEYPSVLMYLNATQTARVAQLPLKTCHLEDFLDKSASGPGLAFIVFTEAVLHMPGASVWSVLFFGMLFTLGLSSMFGNMEGVITPLLDMGILPKGIPKEVMTGVICFACFLSAICFTLQSGGYWLEIFDSFAASLNLIIFAFMEVVGVIHIYGMKRFCDDIEWMTGRRPGLYWQVTWRVVSPMLLFGIFLSYIVLLIQTPPSYKAWNPQYEHFPSREEKFYPGWVQVTCVLLSFLPSLWVPGVALAQLLSQYKQRWKATHLESGLKLQESRGC
uniprot
proteins
function
FUNCTION: Symporter that transports one amino acid molecule together with two sodium and one chloride ions in kidneys and plays a role in the neutral amino acids reabsorption (PubMed:19478081, PubMed:20377526, PubMed:26240152). Preferentially transports neutral amino acids such as L-glycine and L-alanine but also other neutral amino acids (PubMed:19478081, PubMed:20377526, PubMed:26240152). Required CLTRN for cell surface expression and for its amino acid transporter activity (PubMed:20377526, PubMed:26240152). The transport mechanism is pH-independent (PubMed:19478081). {ECO:0000269|PubMed:19478081, ECO:0000269|PubMed:20377526, ECO:0000269|PubMed:26240152}.
uniprot
proteins
mass_dalton
69229
uniprot
proteins
mutagenesis
MUTAGEN 21; /note="D->N: No effect on protein abundance. Increases localization to the cell membrane. Increases alanine uptake activity."; /evidence="ECO:0000269|PubMed:26240152"; MUTAGEN 25; /note="Q->D: No effect on protein abundance. Almost complete loss of cell surface localization. Decreases alanine uptake activity."; /evidence="ECO:0000269|PubMed:26240152"; MUTAGEN 25; /note="Q->V: No effect on protein abundance. Strong decrease of cell surface localization. Decreases alanine uptake."; /evidence="ECO:0000269|PubMed:26240152"; MUTAGEN 50; /note="H->Y: No effect on protein abundance. No effect on cell surface localization. Increases alanine uptake activity."; /evidence="ECO:0000269|PubMed:26240152"; MUTAGEN 72; /note="Y->H: No effect on protein abundance. No effect on cell surface localization. No effect on alanine uptake activity."; /evidence="ECO:0000269|PubMed:26240152"; MUTAGEN 78; /note="G->S: No effect on protein abundance. No effect on cell surface expression. Decreases alanine uptake activity."; /evidence="ECO:0000269|PubMed:26240152"; MUTAGEN 90; /note="K->T: No effect on protein abundance. No effect on cell surface localization. No effect on alanine uptake activity."; /evidence="ECO:0000269|PubMed:26240152"; MUTAGEN 158; /note="S->D: No effect on protein abundance. No effect on cell surface localization. No effect on alanine uptake activity."; /evidence="ECO:0000269|PubMed:26240152"; MUTAGEN 213; /note="L->W: No effect on protein abundance. No effect on cell surface localization. Decreases alanine uptake activity."; /evidence="ECO:0000269|PubMed:26240152"; MUTAGEN 225; /note="R->T: No effect on protein abundance. Strong decreases of cell surface localization. Decreases alanine uptake."; /evidence="ECO:0000269|PubMed:26240152"; MUTAGEN 283; /note="N->D: No effect on protein abundance. Strong decreases of cell surface localization. Decreases alanine uptake."; /evidence="ECO:0000269|PubMed:26240152"; MUTAGEN 287; /note="D->K: No effect on protein abundance. Strong decreases of cell surface localization. Decreases alanine uptake."; /evidence="ECO:0000269|PubMed:26240152"; MUTAGEN 287; /note="D->N: No effect on protein abundance. Strong decreases of cell surface localization. Decreases alanine uptake activity."; /evidence="ECO:0000269|PubMed:26240152"; MUTAGEN 296; /note="S->R: No effect on protein abundance. Strong decreases of cell surface localization. Decreases alanine uptake activity."; /evidence="ECO:0000269|PubMed:26240152"; MUTAGEN 297; /note="M->C: No effect on protein abundance. No effect on cell surface localization. No effect on alanine uptake activity."; /evidence="ECO:0000269|PubMed:26240152"; MUTAGEN 297; /note="M->S: No effect on protein abundance. No effect on cell surface localization. No effect on alanine uptake activity."; /evidence="ECO:0000269|PubMed:26240152"; MUTAGEN 456; /note="I->T: No effect on protein abundance. No effect on cell surface localization. No effect on alanine uptake activity."; /evidence="ECO:0000269|PubMed:26240152"; MUTAGEN 464; /note="G->N: No effect on protein abundance. No effect on cell surface localization. No effect on alanine uptake activity."; /evidence="ECO:0000269|PubMed:26240152"; MUTAGEN 477; /note="L->P: No effect on protein abundance. No effect on cell surface localization. No effect on alanine uptake activity."; /evidence="ECO:0000269|PubMed:26240152"; MUTAGEN 495; /note="G->R: No effect on protein abundance. Strong decreases of cell surface localization. Decreases alanine uptake activity."; /evidence="ECO:0000269|PubMed:26240152"; MUTAGEN 502; /note="D->N: Decreases protein abundance. Strong decreases of cell surface localization. Strong decreases on alanine uptake activity."; /evidence="ECO:0000269|PubMed:26240152"; MUTAGEN 568; /note="Q->R: No effect on protein abundance. No effect on cell surface localization. No effect on alanine uptake activity."; /evidence="ECO:0000269|PubMed:26240152
uniprot
proteins
protein_family
SLC6A18 subfamily
uniprot
proteins
protein_family
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
uniprot
proteins
pubmed
15121838
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19478081
uniprot
proteins
pubmed
20377526
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26240152
uniprot
proteins
pubmed
9932288
uniprot
proteins
sequence_length
615
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:19478081, ECO:0000269|PubMed:20377526}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:20377526, ECO:0000269|PubMed:26240152}; Multi-pass membrane protein {ECO:0000255}. Note=In kidneys localizes to the apical membrane in distal segments of the proximal tubule (PubMed:19478081, PubMed:20377526). Cell membrane expression is CLTRN-dependent (PubMed:20377526). {ECO:0000269|PubMed:19478081, ECO:0000269|PubMed:20377526}.
uniprot
proteins
transmembrane_region
TRANSMEM 27..47; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 53..73; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 106..126; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 178..198; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 207..227; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 256..276; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 289..309; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 398..418; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 442..462; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 473..493; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 521..541; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 571..591; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins