Gabra6
entrez
14399
canonical
uniprot
P16305
canonical
ensembl
ENSMUSG00000020428
resolver
ensp
ENSMUSP00000020703
resolver
ensp
ENSMUSP00000104909
resolver
ensp
ENSMUSP00000126114
resolver
genesymbol
Gabra6
resolver
genesymbol_syn
Gabra-6
resolver
uniprot
Q5SUU5
resolver
uniprot
Q9R0V3
resolver
uniprot
Q9R0V4
resolver
uniprot
Q9R0V5
resolver
uniprot_entry
GBRA6_MOUSE
resolver
uniprot_sec
Q5SUU5
resolver
uniprot_sec
Q9R0V3
resolver
uniprot_sec
Q9R0V4
resolver
uniprot_sec
Q9R0V5
resolver
amino_acid_sequence
MVLLLPWLFIILWLENAQAQLEDEGNFYSENVSRILDNLLEGYDNRLRPGFGGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFKGPAEILSLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRLMQNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYPKTEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSETIKSNTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNLQSQKAERQAQTAATPPVAKSKASESLQAEIVVHSDSKYHLKKRISSLTLPIVPSSEASKALSRTPILKSTPVSPPLLLPATGGTSKIDQYSRILFPVAFAGFNLVYWIVYLSKDTMEVSSTVE
uniprot
proteins
function
FUNCTION: Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (By similarity). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Alpha-6/GABRA6 subunits are found at both synaptic and extrasynaptic sites (By similarity). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). Extrasynaptic alpha-6-containing receptors contribute to the tonic GABAergic inhibition. Alpha-6 subunits are also present on glutamatergic synapses (By similarity). {ECO:0000250|UniProtKB:P08219, ECO:0000250|UniProtKB:P14867, ECO:0000250|UniProtKB:P30191}.
uniprot
proteins
mass_dalton
51106
uniprot
proteins
protein_family
GABRA6 sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
11528422
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2167378
uniprot
proteins
sequence_length
453
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:P30191}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:P30191}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 244..264; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 271..290; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 305..325; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 423..443; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins