Sgta
entrez
52551
canonical
uniprot
Q8BJU0
canonical
ensembl
ENSMUSG00000004937
resolver
ensp
ENSMUSP00000005067
resolver
ensp
ENSMUSP00000151949
resolver
ensp
ENSMUSP00000279220
resolver
ensp
ENSMUSP00000279223
resolver
genesymbol
Sgta
resolver
genesymbol_syn
Sgt
resolver
uniprot
Q3TN35
resolver
uniprot
Q8BGA6
resolver
uniprot
Q99L52
resolver
uniprot_entry
Q3TN35_MOUSE
resolver
uniprot_entry
SGTA_MOUSE
resolver
uniprot_sec
Q8BGA6
resolver
uniprot_sec
Q99L52
resolver
amino_acid_sequence
MDNRKRLAYAIIQFLHGQLRHGGLSCDAQESLEVAIQCLETAFGVTLEDSDLALPQTLPEIFEAATSSKQEMPQDPRAPDRTPPSEEDSAEAERLKTEGNEQMKLENFEAAVHLYGKAIELNPANAVYFCNRAAAYSKLGNYVGAVQDCERAIGIDPGYSKAYGRMGLALSSLNKHAEAVAYYKKALELDPDNDTYKSNLKIAELKLREAPSPTGGVGSLDIAGLLNNPHFITMASSLMNSPQLQQLMSGMISGGHNPLGTPGSSPQQSDLASLIQAGQQFAQQMQQQNPEFVEQIRSQVVRSRTPSASHEEQQE
uniprot
proteins
function
FUNCTION: Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails. Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module. Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins. It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states. Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex. Binds directly to HSC70 and HSP70 and regulates their ATPase activity. {ECO:0000250|UniProtKB:O43765}.
uniprot
proteins
mass_dalton
34322
uniprot
proteins
protein_family
SGT family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17034881
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
315
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O43765}. Nucleus {ECO:0000250|UniProtKB:O43765}. Note=Co-localizes with HSP90AB1 in the cytoplasm. Increased nuclear accumulation seen during cell apoptosis. {ECO:0000250|UniProtKB:O43765}.
uniprot
proteins