Nox4
entrez
50490
canonical
uniprot
Q9JHI8
canonical
ensembl
ENSMUSG00000030562
resolver
ensp
ENSMUSP00000032781
resolver
genesymbol
Nox4
resolver
genesymbol_syn
Renox
resolver
uniprot
B2RSM1
resolver
uniprot
B5AN18
resolver
uniprot
Q3TF39
resolver
uniprot
Q8C3M1
resolver
uniprot
Q8VCA3
resolver
uniprot_entry
B2RSM1_MOUSE
resolver
uniprot_entry
NOX4_MOUSE
resolver
uniprot_sec
B5AN18
resolver
uniprot_sec
Q3TF39
resolver
uniprot_sec
Q8C3M1
resolver
uniprot_sec
Q8VCA3
resolver
activity_regulation
ACTIVITY REGULATION: Activated by insulin. Inhibited by diphenylene iodonium (By similarity). Inhibited by plumbagin. Activated by phorbol 12-myristate 13-acetate (PMA). {ECO:0000250|UniProtKB:Q9NPH5, ECO:0000269|PubMed:10869423, ECO:0000269|PubMed:15638999}.
uniprot
proteins
amino_acid_sequence
MAVSWRSWLANEGVKHLCLLIWLSLNVLLFWKTFLLYNQGPEYYYIHQMLGLGLCLSRASASVLNLNCSLILLPMCRTVLAYLRGSQKVPSRRTRRLLDKSKTLHITCGVTICIFSGVHVAAHLVNALNFSVNYSEDFLELNAARYQNEDPRKLLFTTIPGLTGVCMVVVLFLMVTASTYAIRVSNYDIFWYTHNLFFVFYMLLLLHVSGGLLKYQTNVDTHPPGCISLNQTSSQNMSIPDYVSEHFHGSLPRGFSKLEDRYQKTLVKICLEEPKFQAHFPQTWIWISGPLCLYCAERLYRCIRSNKPVTIISVINHPSDVMELRMIKENFKARPGQYIILHCPSVSALENHPFTLTMCPTETKATFGVHFKVVGDWTERFRDLLLPPSSQDSEILPFIHSRNYPKLYIDGPFGSPFEESLNYEVSLCVAGGIGVTPFASILNTLLDDWKPYKLRRLYFIWVCRDIQSFQWFADLLCVLHNKFWQENRPDFVNIQLYLSQTDGIQKIIGEKYHTLNSRLFIGRPRWKLLFDEIAKCNRGKTVGVFCCGPSSISKTLHSLSNRNNSYGTKFEYNKESFS
uniprot
proteins
ec_number
1.6.3.1
uniprot
proteins
function
FUNCTION: NADPH oxidase that catalyzes predominantly the reduction of oxygen to H2O2 (By similarity). Can also catalyze to a smaller extent, the reduction of oxygen to superoxide (PubMed:10869423, PubMed:11098048, PubMed:15638999). May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity (By similarity). May regulate insulin signaling cascade (By similarity). May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB (By similarity). May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation (By similarity). Promotes ferroptosis, reactive oxygen species production and reduced glutathione (GSH) levels by activating NLRP3 inflammasome activation and cytokine release (By similarity). {ECO:0000250|UniProtKB:Q9NPH5, ECO:0000269|PubMed:10869423, ECO:0000269|PubMed:11098048, ECO:0000269|PubMed:15638999}.; FUNCTION: [Isoform 5]: NADPH oxidase that catalyzes the reduction of oxygen to H2O2. Reactive oxygen species production activates MAPK1/MAPK3 signaling and leads to the activation of ELK1 transcription factor. {ECO:0000269|PubMed:23393389}.
uniprot
proteins
mass_dalton
66519
uniprot
proteins
mutagenesis
MUTAGEN Q9JHI8-5:130; /note="P->H: Decreased reactive oxygen species production."; /evidence="ECO:0000269|PubMed:23393389
uniprot
proteins
post_translational_modification
PTM: N-glycosylation is required for the function. {ECO:0000250|UniProtKB:Q9NPH5}.
uniprot
proteins
pubmed
10869423
uniprot
proteins
pubmed
11032835
uniprot
proteins
pubmed
11098048
uniprot
proteins
pubmed
15016652
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15638999
uniprot
proteins
pubmed
15802177
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23393389
uniprot
proteins
sequence_length
578
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9NPH5}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23393389}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9NPH5}; Multi-pass membrane protein {ECO:0000255}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q924V1}. Nucleus {ECO:0000250|UniProtKB:Q9NPH5}.; SUBCELLULAR LOCATION: [Isoform 5]: Nucleus {ECO:0000269|PubMed:23393389}. Nucleus, nucleolus {ECO:0000269|PubMed:23393389}.
uniprot
proteins
transmembrane_region
TRANSMEM 17..37; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 63..83; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 105..125; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 155..175; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 189..209; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 425..445; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins