BFAR
entrez
51283
canonical
uniprot
Q9NZS9
canonical
ensembl
ENSG00000103429
resolver
ensembl
ENSG00000275618
resolver
ensp
ENSP00000261658
resolver
ensp
ENSP00000454476
resolver
ensp
ENSP00000487878
resolver
ensp
ENSP00000571160
resolver
enst
ENST00000563971
resolver
enst
ENST00000632391
resolver
genesymbol
BFAR
resolver
genesymbol_syn
BAR
resolver
genesymbol_syn
RNF47
resolver
hgnc
HGNC:17613
resolver
uniprot
A8K4Z9
resolver
uniprot
B4DUT0
resolver
uniprot
D3DUG8
resolver
uniprot
H3BMP2
resolver
uniprot_entry
BFAR_HUMAN
resolver
uniprot_entry
H3BMP2_HUMAN
resolver
uniprot_sec
A8K4Z9
resolver
uniprot_sec
B4DUT0
resolver
uniprot_sec
D3DUG8
resolver
amino_acid_sequence
MEEPQKSYVNTMDLERDEPLKSTGPQISVSEFSCHCCYDILVNPTTLNCGHSFCRHCLALWWASSKKTECPECREKWEGFPKVSILLRDAIEKLFPDAIRLRFEDIQQNNDIVQSLAAFQKYGNDQIPLAPNTGRANQQMGGGFFSGVLTALTGVAVVLLVYHWSSRESEHDLLVHKAVAKWTAEEVVLWLEQLGPWASLYRERFLSERVNGRLLLTLTEEEFSKTPYTIENSSHRRAILMELERVKALGVKPPQNLWEYKAVNPGRSLFLLYALKSSPRLSLLYLYLFDYTDTFLPFIHTICPLQEDSSGEDIVTKLLDLKEPTWKQWREFLVKYSFLPYQLIAEFAWDWLEVHYWTSRFLIINAMLLSVLELFSFWRIWSRSELKTVPQRMWSHFWKVSTQGLFVAMFWPLIPQFVCNCLFYWALYFNPIINIDLVVKELRRLETQVL
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Membrane-bound E3 ubiquitin ligase that plays a role in several processes including apoptosis regulation or reticulum endoplasmic stress (PubMed:14502241, PubMed:21068390). Has anti-apoptotic activity, both for apoptosis triggered via death-receptors and via mitochondrial factors (PubMed:14502241). Contributes to the dynamic control of IRE1/ERN1 signaling during ER stress by inducing BAX inhibitor 1/TMBIM6 proteasomal degradation (PubMed:21068390). Promotes the activation of TGF-beta signaling by mediating the 'Lys-63'-linked ubiquitination of TGFBR1 which is critical to activate the pathway (PubMed:33914044). Together with NGFR, negatively regulates NF-kappa-B and JNK-related signaling pathways (PubMed:22566094). Promotes the proteasome-mediated degradation of PNPLA3, a protein involveld in lipid metabolism (PubMed:38294943). {ECO:0000269|PubMed:14502241, ECO:0000269|PubMed:21068390, ECO:0000269|PubMed:22566094, ECO:0000269|PubMed:33914044, ECO:0000269|PubMed:38294943}.
uniprot
proteins
mass_dalton
52738
uniprot
proteins
post_translational_modification
PTM: Mediates RING-dependent self-ubiquitination leading to proteasomal degradation. {ECO:0000269|PubMed:21068390}.
uniprot
proteins
pubmed
10716992
uniprot
proteins
pubmed
14502241
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
21068390
uniprot
proteins
pubmed
22566094
uniprot
proteins
pubmed
33914044
uniprot
proteins
pubmed
38294943
uniprot
proteins
sequence_length
450
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:10716992, ECO:0000269|PubMed:14502241, ECO:0000269|PubMed:21068390, ECO:0000269|PubMed:22566094}; Multi-pass membrane protein {ECO:0000269|PubMed:10716992, ECO:0000269|PubMed:14502241}.
uniprot
proteins
transmembrane_region
TRANSMEM 141..161; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 332..352; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 361..381; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 405..425; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins