KBTBD7
entrez
84078
canonical
uniprot
Q8WVZ9
canonical
ensembl
ENSG00000120696
resolver
ensp
ENSP00000368797
resolver
enst
ENST00000379483
resolver
genesymbol
KBTBD7
resolver
hgnc
HGNC:25266
resolver
uniprot
B5TZ86
resolver
uniprot
Q5T6Y7
resolver
uniprot
Q8NB99
resolver
uniprot
Q9H0I6
resolver
uniprot_entry
KBTB7_HUMAN
resolver
uniprot_sec
B5TZ86
resolver
uniprot_sec
Q5T6Y7
resolver
uniprot_sec
Q8NB99
resolver
uniprot_sec
Q9H0I6
resolver
amino_acid_sequence
MQSREDVPRSRRLASPRGGRRPKRISKPSVSAFFTGPEELKDTAHSAALLAQLKSFYDARLLCDVTIEVVTPGSGPGTGRLFSCNRNVLAAACPYFKSMFTGGMYESQQASVTMHDVDAESFEVLVDYCYTGRVSLSEANVQRLYAASDMLQLEYVREACASFLARRLDLTNCTAILKFADAFDHHKLRSQAQSYIAHNFKQLSRMGSIREETLADLTLAQLLAVLRLDSLDIESERTVCHVAVQWLEAAAKERGPSAAEVFKCVRWMHFTEEDQDYLEGLLTKPIVKKYCLDVIEGALQMRYGDLLYKSLVPVPNSSSSSSSSNSLVSAAENPPQRLGMCAKEMVIFFGHPRDPFLCYDPYSGDIYTMPSPLTSFAHTKTVTSSAVCVSPDHDIYLAAQPRKDLWVYKPAQNSWQQLADRLLCREGMDVAYLNGYIYILGGRDPITGVKLKEVECYSVQRNQWALVAPVPHSFYSFELIVVQNYLYAVNSKRMLCYDPSHNMWLNCASLKRSDFQEACVFNDEIYCICDIPVMKVYNPARGEWRRISNIPLDSETHNYQIVNHDQKLLLITSTTPQWKKNRVTVYEYDTREDQWINIGTMLGLLQFDSGFICLCARVYPSCLEPGQSFITEEDDARSESSTEWDLDGFSELDSESGSSSSFSDDEVWVQVAPQRNAQDQQGSL
uniprot
proteins
function
FUNCTION: As part of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex functions as a substrate adapter for the RAC1 guanine exchange factor (GEF) TIAM1, mediating its 'Lys-48' ubiquitination and proteasomal degradation (PubMed:25684205). By controlling this ubiquitination, regulates RAC1 signal transduction and downstream biological processes including the organization of the cytoskeleton, cell migration and cell proliferation (PubMed:25684205). Ubiquitination of TIAM1 requires the membrane-associated protein GABARAP which may restrict locally the activity of the complex (PubMed:25684205). {ECO:0000269|PubMed:25684205}.
uniprot
proteins
mass_dalton
77163
uniprot
proteins
mutagenesis
MUTAGEN 99; /note="M->A: Loss of interaction with CUL3. Loss of function in TIAM1 degradation."; /evidence="ECO:0000269|PubMed:25684205"; MUTAGEN 668..671; /note="WVQV->AVQA: Decreased interaction with GABARAP and GABARAPL2. Loss of function in TIAM1 ubiquitination and degradation. No effect on assembly of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex."; /evidence="ECO:0000269|PubMed:25684205"; MUTAGEN 668; /note="W->A: Decreased interaction with GABARAP and GABARAPL2."; /evidence="ECO:0000269|PubMed:25684205
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:25684205}.
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25684205
uniprot
proteins
sequence_length
684
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:25684205}. Nucleus {ECO:0000305|PubMed:25684205}.
uniprot
proteins