MTRF1L
entrez
54516
canonical
uniprot
Q9UGC7
canonical
ensembl
ENSG00000112031
resolver
ensp
ENSP00000356199
resolver
ensp
ENSP00000356200
resolver
ensp
ENSP00000356202
resolver
ensp
ENSP00000785272
resolver
genesymbol
MTRF1L
resolver
genesymbol_syn
MTRF1A
resolver
hgnc
HGNC:21051
resolver
uniprot
B3KTA0
resolver
uniprot
B4DMX1
resolver
uniprot
Q3KR06
resolver
uniprot
Q5TF44
resolver
uniprot
Q5TF50
resolver
uniprot
Q96CC5
resolver
uniprot
Q96EX4
resolver
uniprot
Q96K40
resolver
uniprot_entry
B4DMX1_HUMAN
resolver
uniprot_entry
RF1ML_HUMAN
resolver
uniprot_sec
B3KTA0
resolver
uniprot_sec
Q3KR06
resolver
uniprot_sec
Q5TF44
resolver
uniprot_sec
Q5TF50
resolver
uniprot_sec
Q96CC5
resolver
uniprot_sec
Q96EX4
resolver
uniprot_sec
Q96K40
resolver
amino_acid_sequence
MRSRVLWGAARWLWPRRAVGPARRPLSSGSPPLEELFTRGGPLRTFLERQAGSEAHLKVRRPELLAVIKLLNEKERELRETEHLLHDENEDLRKLAENEITLCQKEITQLKHQIILLLVPSEETDENDLILEVTAGVGGQEAMLFTSEIFDMYQQYAAFKRWHFETLEYFPSELGGLRHASASIGGSEAYRHMKFEGGVHRVQRVPKTEKQGRVHTSTMTVAILPQPTEINLVINPKDLRIDTKRASGAGGQHVNTTDSAVRIVHLPTGVVSECQQERSQLKNKELAMTKLRAKLYSMHLEEEINKRQNARKIQIGSKGRSEKIRTYNFPQNRVTDHRINKTLHDLETFMQGDYLLDELVQSLKEYADYESLVEIISQKV
uniprot
proteins
function
FUNCTION: Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain termination codons UAA and UAG. {ECO:0000269|PubMed:17803939, ECO:0000269|PubMed:33878294, ECO:0000269|PubMed:37141370}.
uniprot
proteins
mass_dalton
43600
uniprot
proteins
mutagenesis
MUTAGEN 250..251; /note="GG->AA: Impaired mitochondrial peptide chain release factor activity."; /evidence="ECO:0000269|PubMed:37141370
uniprot
proteins
post_translational_modification
PTM: Methylation of glutamine in the GGQ triplet by HEMK1 is conserved from bacteria to mammals. {ECO:0000269|PubMed:18541145, ECO:0000269|PubMed:35260756}.
uniprot
proteins
protein_family
Prokaryotic/mitochondrial release factor family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17803939
uniprot
proteins
pubmed
18541145
uniprot
proteins
pubmed
20075246
uniprot
proteins
pubmed
33878294
uniprot
proteins
pubmed
35260756
uniprot
proteins
pubmed
37141370
uniprot
proteins
sequence_length
380
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:17803939}.
uniprot
proteins