Hmox1
entrez
24451
canonical
uniprot
P06762
canonical
ensembl
ENSRNOG00000014117
resolver
ensembl
ENSRNOG00055021832
resolver
ensembl
ENSRNOG00060015875
resolver
ensembl
ENSRNOG00065004008
resolver
ensp
ENSRNOP00000019192
resolver
ensp
ENSRNOP00055030521
resolver
ensp
ENSRNOP00060021805
resolver
ensp
ENSRNOP00065004199
resolver
enst
ENSRNOT00055037437
resolver
enst
ENSRNOT00060027191
resolver
enst
ENSRNOT00065005841
resolver
genesymbol
Hmox1
resolver
uniprot
Q5BK87
resolver
uniprot_entry
HMOX1_RAT
resolver
uniprot_sec
Q5BK87
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by metalloporphyrins such as Sn- and Zn-protoporphyrins. {ECO:0000269|PubMed:1575508}.
uniprot
proteins
amino_acid_sequence
MERPQLDSMSQDLSEALKEATKEVHIRAENSEFMRNFQKGQVSREGFKLVMASLYHIYTALEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQEAIPYTPATQHYVKRLHEVGGTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSSGEGLAFFTFPSIDNPTKFKQLYRARMNTLEMTPEVKHRVTEEAKTAFLLNIELFEELQALLTEEHKDQSPSQTEFLRQRPASLVQDTTSAETPRGKSQISTSSSQTPLLRWVLTLSFLLATVAVGIYAM
uniprot
proteins
ec_number
1.14.14.18
uniprot
proteins
function
FUNCTION: [Heme oxygenase 1]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron (PubMed:1575508, PubMed:1935972, PubMed:3865203). Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis (By similarity). {ECO:0000250|UniProtKB:P09601, ECO:0000269|PubMed:1575508, ECO:0000269|PubMed:1935972, ECO:0000269|PubMed:3865203}.; FUNCTION: [Heme oxygenase 1 soluble form]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. {ECO:0000269|PubMed:1935972}.
uniprot
proteins
mass_dalton
33006
uniprot
proteins
post_translational_modification
PTM: A soluble form arises by proteolytic removal of the membrane anchor. {ECO:0000305|PubMed:1935972}.
uniprot
proteins
protein_family
Heme oxygenase family
uniprot
proteins
pubmed
10760513
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1575508
uniprot
proteins
pubmed
1935972
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
3032976
uniprot
proteins
pubmed
3865203
uniprot
proteins
sequence_length
289
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:3865203}; Single-pass type IV membrane protein {ECO:0000255}; Cytoplasmic side {ECO:0000250|UniProtKB:P09601}.
uniprot
proteins
transmembrane_region
TRANSMEM 267..289; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins