Gli1
entrez
14632
canonical
uniprot
P47806
canonical
ensembl
ENSMUSG00000025407
resolver
ensp
ENSMUSP00000026474
resolver
enst
ENSMUST00000026474
resolver
genesymbol
Gli1
resolver
genesymbol_syn
Gli
resolver
uniprot
G5E857
resolver
uniprot
Q9QYK1
resolver
uniprot_entry
GLI1_MOUSE
resolver
uniprot_sec
G5E857
resolver
uniprot_sec
Q9QYK1
resolver
activity_regulation
ACTIVITY REGULATION: Maintained in an inactive state by SUFU, which sequesters GLI1 in the cytoplasm (PubMed:20956384). In presence of hedgehog (DHH, IHH or SHH), smoothened is activated, leading to phosphorylation by MAPK1/ERK2 and dissociation from SUFU and translocation to the nucleus (PubMed:20956384). In absence of hedgehog, smoothened is inhibited, promoting degradation of GLI1 (By similarity). {ECO:0000250|UniProtKB:P08151, ECO:0000269|PubMed:20956384}.
uniprot
proteins
amino_acid_sequence
MFNPMTPPQVNSYSEPCCLRPLHSQGVPSMGTEGLSGLPFCHQANFMSGSQGYGAARETSSCTEGSLFPPPPPPRSSVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSPGGSYGHLSIGTMSPSLGFPPQMSHQKGTSPPYGVQPCVPHDSTRGSMMLHPQSRGPRATCQLKSELDMMVGKCPEDPLEGDMSSPNSTGTQDHLLGMLDGREDLEREEKPEPESVYETDCRWDGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEQEGCSKAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAQPLSTVEPKREREGGSGREESRLTVPESAMPQQSPGAQSSCSSDHSPAGSAANTDSGVEMAGNAGGSTEDLSSLDEGPCVSATGLSTLRRLENLRLDQLHQLRPIGSRGLKLPSLTHAGAPVSRRLGPPVSLDRRSSSSSSMSSAYTVSRRSSLASPFPPGTPPENGASSLPGLTPAQHYMLRARYASARGSGTPPTAAHSLDRMGGLSVPPWRSRTEYPGYNPNAGVTRRASDPARAADHPAPARVQRFKSLGCVHTPPSVATGRNFDPHHPTSVYSPQPPSITENVAMDTRGLQEEPEVGTSVMGNGLNPYMDFSSTDTLGYGGPEGTAAEPYEARGPGSLPLGPGPPTNYGPGHCAQQVSYPDPTPENWGEFPSHAGVYPSNKAPGAAYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEGSPGPQPLFSHHPQLPQPQYPQSGPYPQPPHGYLSTEPRLGLNFNPSSSHSTGQLKAQLVCNYVQSQQELLWEGRNRGGLPNQELPYQSPKFLGGSQVSQSPAKTPAAAAAAYGSGFAPASANHKSGSYPAPSPCHETFTVGVNRPSHRPAAPPRLLPPLSPCYGPLKVGDTNPSCGHPEVGRLGAGPALYPPPEGQVCNALDSLDLDNTQLDFVAILDEAQGLSPPLSHEQGDSSKNTPSPSGPPNMAVGNMSVLLGSLPGETQFLNSSA
uniprot
proteins
function
FUNCTION: Transcription activator that acts as a key effector of the smoothened signaling pathway, and which plays a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract (PubMed:10433919, PubMed:10725236, PubMed:11748151, PubMed:17442700, PubMed:19015273). Binds to the DNA consensus sequence 5'-GACCACCCA-3' (PubMed:17442700). Activated in response to smoothened signaling: in presence of hedgehog (DHH, IHH or SHH) and subsequent activation of smoothened, GLI1 translocates to the nucleus and promotes expression of target genes (PubMed:11748151). In contrast to GLI2 and GLI3, does not contain a repressor domain and only acts as a transcription activator (PubMed:10433919). {ECO:0000269|PubMed:10433919, ECO:0000269|PubMed:10725236, ECO:0000269|PubMed:11748151, ECO:0000269|PubMed:17442700, ECO:0000269|PubMed:19015273}.
uniprot
proteins
mass_dalton
118560
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in vitro by ULK3 (By similarity). Phosphorylation by PRKCD inhibits its activity by decreasing its localization to the nucleus (PubMed:19015273). Phosphorylation at Ser-105, Ser-119 and Ser-133 by MAPK1/ERK2 in response to smoothened activation, promotes GLI1 dissociation from SUFU inhibitor and translocation to the nucleus (By similarity). {ECO:0000250|UniProtKB:P08151, ECO:0000269|PubMed:19015273}.; PTM: Acetylation at Lys-520 down-regulates transcriptional activity. Deacetylated by HDAC1. {ECO:0000250|UniProtKB:P08151}.; PTM: Degradaded by the proteasome in absence of smoothened signaling. {ECO:0000250|UniProtKB:P08151}.; PTM: Ubiquitinated by the CRL2(FEM1B) complex, suppressing GLI1 transcriptional activator activity. {ECO:0000250|UniProtKB:P08151}.
uniprot
proteins
protein_family
GLI C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
10433919
uniprot
proteins
pubmed
10725236
uniprot
proteins
pubmed
11748151
uniprot
proteins
pubmed
17442700
uniprot
proteins
pubmed
19015273
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19592253
uniprot
proteins
pubmed
20956384
uniprot
proteins
pubmed
8364225
uniprot
proteins
pubmed
9524201
uniprot
proteins
sequence_length
1111
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19015273}. Nucleus {ECO:0000269|PubMed:17442700, ECO:0000269|PubMed:19015273}. Cell projection, cilium {ECO:0000269|PubMed:20956384}. Note=Sequestered in the cytoplasm by SUFU in absence of smoothened signaling (By similarity). Accumulates in primary cilia following smoothened activation (PubMed:20956384). It then translocates to the nucleus, where is activates transcription of target genes (PubMed:20956384). Activation and translocation to the nucleus is promoted by interaction with STK36 (By similarity). Phosphorylation by ULK3 may promote nuclear localization (By similarity). Translocation to the nucleus is promoted by interaction with ZIC1 (By similarity). {ECO:0000250|UniProtKB:P08151, ECO:0000269|PubMed:20956384}.
uniprot
proteins