Q6IE52
uniprot
Q6IE52
canonical
amino_acid_sequence
MWKNREAQLCLFSVLLAFLPSASLLFGNSKYMVLVPSQLYTETPEKICLHLYHLNETVTVTASLISQRGTRKLFDEPVVDKDLFHCVSFIPRLPSSEEEESLDINIEGAKHKFSKRHVVLVKNKESVVFVQTDKPMYKPGQSVKFRVVSMDKNLYPLKELVQDPKMNRIMQWQDVKTENGLKQLSFSLSAEPIQGPYKIVVLKQSGVKEEHSFTVMEFVLPRFGVDVKVPNAISVYDEIISVTACDRYTYGKPVLGRVKVRLCHGNPSFSSETKSACKEENSQLDNNGCSTQEVNITEFQLKENYLKVRQAFHVNATVTEEGTGMEFGGYGRIEVERTRNKFLFLKADSHFRHGIPFFVKVRLVDIKGDPIPNEQVFIKAQEAGYTNATTTDQHGLAKFSIDTSSISGYSLNIKVYHKEENLCIHSSCTAERHAEAHHTAYAVYSLSKSYIYLDTEAGVLPCNQIHTVQAHFILKGQVLGVLPQIVFHYLVMAQGSILQTGNHTHQVESGAPVQGNFALEIPVEFSMVPMAKMLIYTILPDGEVIADSVKFQVEKCLRNKVHLSFSPSQSLPASQTHMRVTASPQSLCGLRAVDQSVLLLRPEAELSPSLIYDLPGMQDSNFIPRSHHPFEDEDDCLMYQPRDTEELTYSVPYGREKDVYRYVDMGLTAFTNLKIKHPTYCYDLPKEPPRKDPPRKDPEPKDTVVETIRNYFPETWVWDLVTVSSSGVTEVEMTVPDTITEWKAGALCLSNDTGLGLSSVATLQAFQPFFVELTMPYSVIRGEAFTLKATVMNYLPTSLQMTVQLEASPDFTAVPVGNDQDSYCLGANGRHTSSWLVTPKSLGNVNFSVSVEAQQSPEPCGSEVATVPETGRKDTVIKVLIVEPEGIKKEHTFSSLLCASDAELSETLSLLLPPRVVKDSARAHFSVMGDILSSAIKNTQNLIQMPYGCGEQNMVLFAPNIYVLKYLNETQQLTENIKSKALGYLRAGYQRELNYKHKDGSYSAFGDHNGQGQGNTWLTAFVLKSFAQARAFIFIDESHITDAFTWLSKQQKDSGCFRSSGSLFNNAMKGGVDDEITLSAYITMALLESSLPPVVSKALGCLEASWETIEQGRNGSFVYTKALMAYAFTLAGNQEKRNEILKSLDKEAIKEDNSIHWERPQKPMKSEHYLYTPQASSVEVEMSAYVVLARLTAHPAPSPEDLALSTGTIKWLTKQQNSHGGFSSTQDTVVALDALSKYGAATFSKSQKTPSVTVQSSGSFSQKFQVDKSNRLLLQQVSLPDIPGNYTIRVSGEGCVYAQTTLRYNLPLEKQQPAFALKVKTVPLTCNNPKGQNSFQISLEISYTGSRPASNMVIADVKMLSGFIPLKPTVKKLERLEHVSRTEVTTNNVLLYLDQVTNQTLSFSFIIQQDIPVKNLQPAIVKVYDYYETDEVAFAEYSSPCSSDKQNV
uniprot
proteins
function
FUNCTION: A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, for inhibition to be effective. {ECO:0000305}.
uniprot
proteins
mass_dalton
161589
uniprot
proteins
protein_family
Protease inhibitor I39 (alpha-2-macroglobulin) family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15060002
uniprot
proteins
sequence_length
1448
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
uniprot
proteins