Cenpa
entrez
12615
canonical
uniprot
O35216
canonical
ensembl
ENSMUSG00000029177
resolver
ensp
ENSMUSP00000122831
resolver
ensp
ENSMUSP00000143575
resolver
ensp
ENSMUSP00000185666
resolver
enst
ENSMUST00000144742
resolver
genesymbol
Cenpa
resolver
uniprot
Q545C9
resolver
uniprot_entry
CENPA_MOUSE
resolver
uniprot_sec
Q545C9
resolver
amino_acid_sequence
MGPRRKPQTPRRRPSSPAPGPSRQSSSVGSQTLRRRQKFMWLKEIKTLQKSTDLLFRKKPFSMVVREICEKFSRGVDFWWQAQALLALQEAAEAFLIHLFEDAYLLSLHAGRVTLFPKDIQLTRRIRGFEGGLP
uniprot
proteins
function
FUNCTION: Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well-ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). Required for recruitment and assembly of kinetochore proteins, and as a consequence required for progress through mitosis, chromosome segregation and cytokinesis (PubMed:27499292). {ECO:0000250|UniProtKB:P49450, ECO:0000269|PubMed:27499292}.
uniprot
proteins
mass_dalton
15509
uniprot
proteins
post_translational_modification
PTM: Poly-ADP-ribosylated by PARP1.; PTM: Trimethylated by NTMT1 at the N-terminal glycine after cleavage of Met-1. Methylation is low before incorporation into nucleosomes and increases with cell cycle progression, with the highest levels in mitotic nucleosomes. {ECO:0000250|UniProtKB:P49450}.; PTM: Phosphorylated by CDK1 at Ser-62 during early mitosis; this abolishes association with chromatin and centromeres, prevents interaction with HJURP and thereby prevents premature assembly of CENPA into centromeres. Dephosphorylated at Ser-62 by PPP1CA during late mitosis. {ECO:0000250|UniProtKB:P49450}.
uniprot
proteins
protein_family
Histone H3 family
uniprot
proteins
pubmed
12011073
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
27499292
uniprot
proteins
pubmed
9465302
uniprot
proteins
sequence_length
134
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P49450}. Chromosome, centromere {ECO:0000250|UniProtKB:P49450}. Note=Localizes exclusively to sites of kinetochore assembly in centromeres. Occupies a compact domain at the inner kinetochore plate stretching across 2 thirds of the length of the constriction but encompassing only one third of the constriction width and height. Phosphorylation at Ser-62 during early mitosis abolishes association with chromatin and centromeres and results in dispersed nuclear location. {ECO:0000250|UniProtKB:P49450}.
uniprot
proteins