Mbd3
entrez
17192
canonical
uniprot
Q9Z2D8
canonical
ensembl
ENSMUSG00000035478
resolver
ensp
ENSMUSP00000089948
resolver
ensp
ENSMUSP00000100986
resolver
genesymbol
Mbd3
resolver
uniprot
Q792D3
resolver
uniprot
Q8CFJ1
resolver
uniprot_entry
MBD3_MOUSE
resolver
uniprot_sec
Q792D3
resolver
uniprot_sec
Q8CFJ1
resolver
amino_acid_sequence
MERKRWECPALPQGWEREEVPRRSGLSAGHRDVFYYSPSGKKFRSKPQLARYLGGSMDLSTFDFRTGKMLMNKMNKSRQRVRYDSSNQVKGKPDLNTALPVRQTASIFKQPVTKITNHPSNKVKSDPQKAVDQPRQLFWEKKLSGLSAFDIAEELVRTMDLPKGLQGVGPGCTDETLLSAIASALHTSTLPITGQLSAAVEKNPGVWLNTAQPLCKAFMVTDDDIRKQEELVQQVRKRLEEALMADMLAHVEELARDGEAPLDKACAEEEEEEEEEEEEPEPERV
uniprot
proteins
function
FUNCTION: Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (By similarity). Acts as transcriptional repressor and plays a role in gene silencing (By similarity). Does not bind methylated DNA by itself (PubMed:9774669). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides (By similarity). Recruits histone deacetylases and DNA methyltransferases (By similarity). {ECO:0000250|UniProtKB:O95983, ECO:0000269|PubMed:9774669}.
uniprot
proteins
mass_dalton
32168
uniprot
proteins
pubmed
10441743
uniprot
proteins
pubmed
14610093
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30228260
uniprot
proteins
pubmed
30327463
uniprot
proteins
pubmed
9774669
uniprot
proteins
sequence_length
285
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14610093, ECO:0000269|PubMed:9774669}. Chromosome {ECO:0000250|UniProtKB:O95983}. Note=Detected on chromatin, at promoter regions of active genes (By similarity). Nuclear, in discrete foci (PubMed:9774669). {ECO:0000250|UniProtKB:O95983, ECO:0000269|PubMed:9774669}.
uniprot
proteins