SFTPA2
entrez
729238
canonical
uniprot
Q8IWL1
canonical
ensembl
ENSG00000185303
resolver
ensp
ENSP00000361400
resolver
ensp
ENSP00000361402
resolver
ensp
ENSP00000575144
resolver
ensp
ENSP00000575145
resolver
ensp
ENSP00000575147
resolver
ensp
ENSP00000575148
resolver
ensp
ENSP00000575149
resolver
ensp
ENSP00000575150
resolver
ensp
ENSP00000575152
resolver
ensp
ENSP00000575153
resolver
ensp
ENSP00000575154
resolver
ensp
ENSP00000575156
resolver
ensp
ENSP00000575157
resolver
ensp
ENSP00000575158
resolver
ensp
ENSP00000575159
resolver
ensp
ENSP00000575160
resolver
ensp
ENSP00000575161
resolver
ensp
ENSP00000575162
resolver
ensp
ENSP00000575163
resolver
ensp
ENSP00000575165
resolver
ensp
ENSP00000575166
resolver
ensp
ENSP00000575167
resolver
ensp
ENSP00000575168
resolver
ensp
ENSP00000575169
resolver
ensp
ENSP00000575170
resolver
ensp
ENSP00000575171
resolver
ensp
ENSP00000575172
resolver
ensp
ENSP00000575173
resolver
ensp
ENSP00000575174
resolver
ensp
ENSP00000575175
resolver
ensp
ENSP00000575176
resolver
ensp
ENSP00000575177
resolver
ensp
ENSP00000575178
resolver
ensp
ENSP00000629129
resolver
ensp
ENSP00000629131
resolver
ensp
ENSP00000629132
resolver
ensp
ENSP00000629133
resolver
ensp
ENSP00000629137
resolver
ensp
ENSP00000629138
resolver
ensp
ENSP00000629139
resolver
ensp
ENSP00000629140
resolver
ensp
ENSP00000629142
resolver
ensp
ENSP00000629146
resolver
ensp
ENSP00000629148
resolver
ensp
ENSP00000629149
resolver
ensp
ENSP00000629150
resolver
enst
ENST00000372325
resolver
enst
ENST00000372327
resolver
enst
ENST00000905085
resolver
enst
ENST00000905086
resolver
enst
ENST00000905088
resolver
enst
ENST00000905089
resolver
enst
ENST00000905090
resolver
enst
ENST00000905091
resolver
enst
ENST00000905093
resolver
enst
ENST00000905094
resolver
enst
ENST00000905095
resolver
enst
ENST00000905097
resolver
enst
ENST00000905098
resolver
enst
ENST00000905099
resolver
enst
ENST00000905100
resolver
enst
ENST00000905101
resolver
enst
ENST00000905102
resolver
enst
ENST00000905103
resolver
enst
ENST00000905104
resolver
enst
ENST00000905106
resolver
enst
ENST00000905107
resolver
enst
ENST00000905108
resolver
enst
ENST00000905109
resolver
enst
ENST00000905110
resolver
enst
ENST00000905111
resolver
enst
ENST00000905112
resolver
enst
ENST00000905113
resolver
enst
ENST00000905114
resolver
enst
ENST00000905115
resolver
enst
ENST00000905116
resolver
enst
ENST00000905117
resolver
enst
ENST00000905118
resolver
enst
ENST00000905119
resolver
enst
ENST00000959070
resolver
enst
ENST00000959072
resolver
enst
ENST00000959073
resolver
enst
ENST00000959074
resolver
enst
ENST00000959078
resolver
enst
ENST00000959079
resolver
enst
ENST00000959080
resolver
enst
ENST00000959081
resolver
enst
ENST00000959083
resolver
enst
ENST00000959087
resolver
enst
ENST00000959089
resolver
enst
ENST00000959090
resolver
enst
ENST00000959091
resolver
genesymbol
SFTPA2
resolver
genesymbol_syn
COLEC5
resolver
genesymbol_syn
PSAP
resolver
genesymbol_syn
SFTP1
resolver
genesymbol_syn
SFTPA
resolver
genesymbol_syn
SFTPA2B
resolver
hgnc
HGNC:10799
resolver
uniprot
A4QPA7
resolver
uniprot
B2RXI6
resolver
uniprot
B2RXK9
resolver
uniprot
C9J9I7
resolver
uniprot
E3VLC6
resolver
uniprot
E3VLC7
resolver
uniprot
E3VLC8
resolver
uniprot
E3VLC9
resolver
uniprot
P07714
resolver
uniprot
Q14DV3
resolver
uniprot
Q5RIR8
resolver
uniprot
Q5RIR9
resolver
uniprot_entry
SFPA2_HUMAN
resolver
uniprot_sec
A4QPA7
resolver
uniprot_sec
B2RXI6
resolver
uniprot_sec
B2RXK9
resolver
uniprot_sec
C9J9I7
resolver
uniprot_sec
E3VLC6
resolver
uniprot_sec
E3VLC7
resolver
uniprot_sec
E3VLC8
resolver
uniprot_sec
E3VLC9
resolver
uniprot_sec
P07714
resolver
uniprot_sec
Q14DV3
resolver
uniprot_sec
Q5RIR8
resolver
uniprot_sec
Q5RIR9
resolver
amino_acid_sequence
MWLCPLALTLILMAASGAACEVKDVCVGSPGIPGTPGSHGLPGRDGRDGVKGDPGPPGPMGPPGETPCPPGNNGLPGAPGVPGERGEKGEAGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF
uniprot
proteins
disease_involvement
DISEASE: Interstitial lung disease 2 (ILD2) [MIM:178500]: A form of interstitial lung disease, a heterogeneous group of diseases affecting the distal part of the lung and characterized by a progressive remodeling of the alveolar interstitium. The disease spectrum ranges from idiopathic interstitial pneumonia or pneumonitis to idiopathic pulmonary fibrosis, that is associated with an increased risk of developing lung cancer. Clinical features of interstitial lung disease include dyspnea, clubbing of the fingers, and restrictive lung capacity. ILD2 inheritance is autosomal dominant. {ECO:0000269|PubMed:19100526, ECO:0000269|PubMed:26792177, ECO:0000269|PubMed:32855221}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration.
uniprot
proteins
mass_dalton
26169
uniprot
proteins
post_translational_modification
PTM: N-acetylated. {ECO:0000269|PubMed:3755136}.
uniprot
proteins
protein_family
SFTPA family
uniprot
proteins
pubmed
1372511
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19100526
uniprot
proteins
pubmed
20693318
uniprot
proteins
pubmed
2610270
uniprot
proteins
pubmed
26792177
uniprot
proteins
pubmed
32855221
uniprot
proteins
pubmed
3755136
uniprot
proteins
pubmed
9813381
uniprot
proteins
sequence_length
248
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:26792177, ECO:0000269|PubMed:32855221}. Secreted, extracellular space, extracellular matrix. Secreted, extracellular space, surface film.
uniprot
proteins