Smad2
entrez
29357
canonical
uniprot
O70436
canonical
ensembl
ENSRNOG00000018140
resolver
ensembl
ENSRNOG00055013852
resolver
ensembl
ENSRNOG00060010583
resolver
ensembl
ENSRNOG00065022764
resolver
ensp
ENSRNOP00000048329
resolver
ensp
ENSRNOP00000071524
resolver
ensp
ENSRNOP00000075341
resolver
ensp
ENSRNOP00000097880
resolver
ensp
ENSRNOP00000105745
resolver
ensp
ENSRNOP00055019469
resolver
ensp
ENSRNOP00060013920
resolver
ensp
ENSRNOP00065031768
resolver
enst
ENSRNOT00000046847
resolver
enst
ENSRNOT00000089468
resolver
enst
ENSRNOT00055023871
resolver
enst
ENSRNOT00060017914
resolver
enst
ENSRNOT00065039114
resolver
genesymbol
Smad2
resolver
genesymbol_syn
Madh2
resolver
uniprot
A0A0G2K0P2
resolver
uniprot
A0JPM1
resolver
uniprot_entry
A0A0G2K0P2_RAT
resolver
uniprot_entry
SMAD2_RAT
resolver
uniprot_sec
A0JPM1
resolver
amino_acid_sequence
MSSILPFTPPVVKRLLGWKKSAGGSGGAGGGEQNGQEEKWCEKAVKSLVKKLKKTGRLDELEKAITTQNCNTKCVTIPSTCSEIWGLSTANTVDQWDTTGLYSFSEQTRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELKAIENCEYAFSLKKDEVCVNPYHYQRVETPVLPPVLVPRHTEILTELPPLDDYTHSIPENTNFPAGIEPQSNYIPETPPPGYISEDGETSDQQLNQSMDTGSPAELSPTTLSPVNHSLDLQPVTYSEPAFWCSIAYYELNQRVGETFHASQPSLTVDGFTDPSNSERFCLGLLSNVNRNATVEMTRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNNQEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQWLDKVLTQMGSPSVRCSSMS
uniprot
proteins
function
FUNCTION: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). {ECO:0000250|UniProtKB:Q15796, ECO:0000250|UniProtKB:Q62432}.
uniprot
proteins
mass_dalton
52239
uniprot
proteins
post_translational_modification
PTM: In response to TGF-beta, phosphorylated on the C-terminal SXS motif by TGF-beta and activin type 1 receptor kinases, phosphorylation declines progressively in a KMT5A-dependent manner. Phosphorylation in this motif is required for interaction with a number of proteins including SMURF2, SNON and SMAD4 in response to TGF-beta. Dephosphorylated in this motif by PPM1A leading to disruption of the SMAD2/3-SMAD4 complex, nuclear export and termination of the TGF-beta signaling. In response to decorin, the naturally occurring inhibitor of TGF-beta signaling, phosphorylated on Ser-240 by CaMK2. Phosphorylated by MAPK3 upon EGF stimulation; which increases transcriptional activity and stability, and is blocked by calmodulin. Phosphorylated by PDPK1 (By similarity). {ECO:0000250|UniProtKB:Q15796}.; PTM: Acetylated on Lys-19 by coactivators in response to TGF-beta signaling, which increases transcriptional activity. {ECO:0000250|UniProtKB:Q15796}.; PTM: In response to TGF-beta, ubiquitinated by NEDD4L; which promotes its degradation. Monoubiquitinated, leading to prevent DNA-binding (By similarity). Deubiquitination by USP15 alleviates inhibition and promotes activation of TGF-beta target genes (By similarity). Ubiquitinated by RNF111, leading to its degradation: only SMAD2 proteins that are 'in use' are targeted by RNF111, RNF111 playing a key role in activating SMAD2 and regulating its turnover (By similarity). {ECO:0000250|UniProtKB:Q15796, ECO:0000250|UniProtKB:Q62432}.
uniprot
proteins
protein_family
Dwarfin/SMAD family
uniprot
proteins
pubmed
10382592
uniprot
proteins
pubmed
10670756
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21791611
uniprot
proteins
sequence_length
467
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q15796}. Nucleus {ECO:0000250|UniProtKB:Q15796}. Note=Cytoplasmic and nuclear in the absence of TGF-beta (By similarity). On TGF-beta stimulation, migrates to the nucleus when complexed with SMAD4 or with IPO7 (By similarity). On dephosphorylation by phosphatase PPM1A, released from the SMAD2/SMAD4 complex, and exported out of the nucleus by interaction with RANBP1 (By similarity). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity). {ECO:0000250|UniProtKB:Q15796, ECO:0000250|UniProtKB:Q62432}.
uniprot
proteins