Itpripl1
entrez
73338
canonical
uniprot
A2ASA8
canonical
ensembl
ENSMUSG00000074825
resolver
ensp
ENSMUSP00000106016
resolver
ensp
ENSMUSP00000118487
resolver
ensp
ENSMUSP00000122289
resolver
enst
ENSMUST00000110386
resolver
enst
ENSMUST00000132773
resolver
enst
ENSMUST00000154021
resolver
genesymbol
Itpripl1
resolver
uniprot
A1L3P2
resolver
uniprot
A2ASB0
resolver
uniprot
B7ZCY2
resolver
uniprot_entry
A2ASB0_MOUSE
resolver
uniprot_entry
IPIL1_MOUSE
resolver
uniprot_sec
A1L3P2
resolver
uniprot_sec
B7ZCY2
resolver
amino_acid_sequence
MAVISLMFLAVMYVVHHPLMVSDRMDLDTLARSRQLEKRMSEEMRQLEMEFEERSRAAEQKQKVENFWRGDTSSDQLVLGKKDMGWPFQAGGQDGGPLGWILGNLWNAGLFCLFLIFELLRQSMQHEPAFESSSEEEEEEIRVVPVSSYTRLSDFPSQEALEAFYKHYIQNAIRDLPCTCEFVESFVDDLIEACRVLSRREAHPQLEDCLGFGAAFEKWGTLHETQNFDVLVPIVPPQGTMFILEMRDPALGRRCGCVKVDSECMCKHEKLLGDVLCLVHHRDHSAMLSKCTSSIKAALCTSSHLDVCKTVQWFRNMVSNAWALVAHKYDFKLTFPPSTTSCKLRLGYRSGRSLSISLVLGVQREDTLVYLVSQAPEQEQLTSVDWPESFAACEHLFLKLVGRFAPENTCHLKCLQIVLSLQDHQILPPGASRPILTSYHFKTALMHLLLRLPLTDWQHSMLSLRLQDLLWFLGRGLQQRSLHHFLIGNTYLPLTIPIPKAFRNAEPVNLFQHLVLNPVAHSQAVEEFHNLLAQVKTLPCSPVAGGL
uniprot
proteins
function
FUNCTION: Functions as a ligand of CD3E, inhibiting TCR-CD3 complex signaling to regulate T cell activation. Induces stable CD3E-NCK1 binding, thereby preventing the CD3E-ZAP70 interaction and subsequently inhibiting the activation of the downstream ERK-NFkB signaling cascade and calcium influx. {ECO:0000250|UniProtKB:Q6GPH6}.
uniprot
proteins
mass_dalton
62217
uniprot
proteins
protein_family
ITPRIP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
547
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6GPH6}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 97..117; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins