Tmprss6
entrez
71753
canonical
uniprot
Q9DBI0
canonical
ensembl
ENSMUSG00000016942
resolver
ensp
ENSMUSP00000017086
resolver
ensp
ENSMUSP00000155401
resolver
ensp
ENSMUSP00000295508
resolver
enst
ENSMUST00000230226
resolver
genesymbol
Tmprss6
resolver
uniprot
A0A2R8W6T9
resolver
uniprot
A8W478
resolver
uniprot
A8W479
resolver
uniprot
Q3KN88
resolver
uniprot
Q6PF94
resolver
uniprot_entry
A0A2R8W6T9_MOUSE
resolver
uniprot_entry
TMPS6_MOUSE
resolver
uniprot_sec
A8W478
resolver
uniprot_sec
A8W479
resolver
uniprot_sec
Q3KN88
resolver
uniprot_sec
Q6PF94
resolver
amino_acid_sequence
MPRCFQLPCSTRMPTTEVPQAADGQGDAGDGEEAAEPEGKFKPPKNTKRKNRDYVRFTPLLLVLAALVSAGVMLWYFLGYKAEVTVSQVYSGSLRVLNRHFSQDLGRRESIAFRSESAKAQKMLQELVASTRLGTYYNSSSVYSFGEGPLTCFFWFILDIPEYQRLTLSPEVVRELLVDELLSNSSTLASYKTEYEVDPEGLVILEASVNDIVVLNSTLGCYRYSYVNPGQVLPLKGPDQQTTSCLWHLQGPEDLMIKVRLEWTRVDCRDRVAMYDAAGPLEKRLITSVYGCSRQEPVMEVLASGSVMAVVWKKGMHSYYDPFLLSVKSVAFQDCQVNLTLEGRLDTQGFLRTPYYPSYYSPSTHCSWHLTVPSLDYGLALWFDAYALRRQKYNRLCTQGQWMIQNRRLCGFRTLQPYAERIPMVASDGVTINFTSQISLTGPGVQVYYSLYNQSDPCPGEFLCSVNGLCVPACDGIKDCPNGLDERNCVCRAMFQCQEDSTCISLPRVCDRQPDCLNGSDEEQCQEGVPCGTFTFQCEDRSCVKKPNPECDGQSDCRDGSDEQHCDCGLQGLSSRIVGGTVSSEGEWPWQASLQIRGRHICGGALIADRWVITAAHCFQEDSMASPKLWTVFLGKMRQNSRWPGEVSFKVSRLFLHPYHEEDSHDYDVALLQLDHPVVYSATVRPVCLPARSHFFEPGQHCWITGWGAQREGGPVSNTLQKVDVQLVPQDLCSEAYRYQVSPRMLCAGYRKGKKDACQGDSGGPLVCREPSGRWFLAGLVSWGLGCGRPNFFGVYTRVTRVINWIQQVLT
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Membrane-bound serine protease (PubMed:18451267). Through the cleavage of cell surface HJV, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis (PubMed:18451267). {ECO:0000269|PubMed:18451267}.
uniprot
proteins
mass_dalton
90978
uniprot
proteins
mutagenesis
MUTAGEN 762; /note="S->A: Protease-dead."; /evidence="ECO:0000269|PubMed:18451267
uniprot
proteins
post_translational_modification
PTM: The single-chain zymogen undergoes autoproteolytic processing. This results in TMPRSS6 shedding from the cell surface and conversion into an activated two-chains form which is released extracellularly. The process involves a trans-activation mechanism that requires TMPRSS6 oligomerization. {ECO:0000250|UniProtKB:Q8IU80}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
12744720
uniprot
proteins
pubmed
12784999
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17981570
uniprot
proteins
pubmed
18451267
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
811
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12744720}; Single-pass type II membrane protein {ECO:0000269|PubMed:12744720}. Note=The processed, activated two-chains form is released in the extracellular space. {ECO:0000250|UniProtKB:Q8IU80}.
uniprot
proteins
transmembrane_region
TRANSMEM 60..80; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins