Inhbe
entrez
83711
canonical
uniprot
O88959
canonical
ensembl
ENSRNOG00000007601
resolver
ensp
ENSRNOP00000010106
resolver
enst
ENSRNOT00000010106
resolver
genesymbol
Inhbe
resolver
uniprot
A0A0G2JSJ0
resolver
uniprot
Q9R285
resolver
uniprot_entry
A0A0G2JSJ0_RAT
resolver
uniprot_entry
INHBE_RAT
resolver
uniprot_sec
Q9R285
resolver
amino_acid_sequence
MGLSNVQLWTILLWALAWVQSTRSACPSCGAPTLTPQGERALVLELAKQQILEGLHLTSRPRITRPLPQAALTRALRRLQPRSMVPGNREKVISFATSIDKSTSTYRSVLTFQLSPLWSHHLYHARLWLHVPPSFPATLYLRIFGCGTTRCRGSRTFLAEHQTTSSGWHALTLPSSGLRSEESGVTKLQLEFRPLDLNSTTARLPRLLLDTAGQQRPFLELKIRANEPGAGRARRRTPTCESETPLCCRRDHYVDFQELGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASFHSAVFSLLKANNPWPAGSSCCVPTARRPLSLLYLDHNGNVVKTDVPDMVVEACGCS
uniprot
proteins
function
FUNCTION: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.; FUNCTION: Activin E is a homodimer of INHBE secreted by the liver that plays a crucial role in regulating metabolic homeostasis particularly in lipid metabolism and energy homeostasis. Plays a central role in the regulation of adipose tissue lipolysis by preventing the influx of fatty acids from adipose tissue into the liver. Mechanistically, signals via ACVR1C to activate SMAD2/3 signaling, suppressing PPARG target genes in adipose tissue, thereby reducing liver lipid content and improving glycemic control. Induces beige adipocyte formation and thermogenesis in response to cold exposure. {ECO:0000250|UniProtKB:O08717, ECO:0000250|UniProtKB:P58166}.
uniprot
proteins
mass_dalton
38899
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
10828834
uniprot
proteins
sequence_length
350
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
uniprot
proteins