SPRED3
entrez
399473
canonical
uniprot
Q2MJR0
canonical
ensembl
ENSG00000188766
resolver
ensp
ENSP00000345405
resolver
ensp
ENSP00000510478
resolver
genesymbol
SPRED3
resolver
genesymbol_syn
EVE-3
resolver
hgnc
HGNC:31041
resolver
uniprot
B9EKV1
resolver
uniprot
Q2MJR1
resolver
uniprot_entry
B9EKV1_HUMAN
resolver
uniprot_entry
SPRE3_HUMAN
resolver
uniprot_sec
Q2MJR1
resolver
amino_acid_sequence
MVRVRAVVMARDDSSGGWLPVGGGGLSQVSVCRVRGARPEGGARQGHYVIHGERLRDQKTTLECTLKPGLVYNKVNPIFHHWSLGDCKFGLTFQSPAEADEFQKSLLAALAALGRGSLTPSSSSSSSSPSQDTAETPCPLTSHVDSDSSSSHSRQETPPSAAAAPIITMESASGFGPTTPPQRRRSSAQSYPPLLPFTGIPEPSEPLAGAGGLGWGGRGYEDYRRSGPPAPLALSTCVVRFAKTGALRGAALGPPAALPAPLTEAAPPAPPARPPPGPGPSSAPAKASPEAEEAARCVHCRALFRRRADGRGGRCAEAPDPGRLLVRRLSCLWCAESLLYHCLSDAEGDFSDPCACEPGHPRPAARWAALAALSLAVPCLCCYAPLRACHWVAARCGCAGCGGRHEEAAR
uniprot
proteins
function
FUNCTION: Tyrosine kinase substrate that inhibits growth-factor-mediated activation of MAP kinase (By similarity). Inhibits fibroblast growth factor (FGF)-induced retinal lens fiber differentiation, probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By similarity). Inhibits TGFB-induced epithelial-to-mesenchymal transition in lens epithelial cells (By similarity). {ECO:0000250|UniProtKB:Q6P6N5}.
uniprot
proteins
mass_dalton
42670
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine. {ECO:0000269|PubMed:17094949}.; PTM: Palmitoylated by ZDHHC17/HIP14. {ECO:0000250|UniProtKB:Q6P6N5}.; PTM: Ubiquitinated. {ECO:0000269|PubMed:17094949}.
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
16478641
uniprot
proteins
pubmed
17094949
uniprot
proteins
pubmed
24705354
uniprot
proteins
sequence_length
410
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6P6N5}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q6P6N5}.
uniprot
proteins