CNOT6L
entrez
246175
canonical
uniprot
Q96LI5
canonical
ensembl
ENSG00000138767
resolver
ensp
ENSP00000423750
resolver
ensp
ENSP00000424896
resolver
ensp
ENSP00000425571
resolver
ensp
ENSP00000497467
resolver
ensp
ENSP00000543671
resolver
enst
ENST00000512485
resolver
enst
ENST00000515506
resolver
enst
ENST00000649644
resolver
genesymbol
CNOT6L
resolver
genesymbol_syn
CCR4B
resolver
hgnc
HGNC:18042
resolver
uniprot
B4E0K8
resolver
uniprot
H0Y9C1
resolver
uniprot
H0Y9Z5
resolver
uniprot
Q9UF92
resolver
uniprot_entry
B4E0K8_HUMAN
resolver
uniprot_entry
CNO6L_HUMAN
resolver
uniprot_entry
H0Y9C1_HUMAN
resolver
uniprot_entry
H0Y9Z5_HUMAN
resolver
uniprot_sec
Q9UF92
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by free AMP, and with lesser efficiency also by CMP, GMP, UMP, ATP and neomycin. {ECO:0000269|PubMed:27013054}.
uniprot
proteins
amino_acid_sequence
MRLIGMPKEKYDPPDPRRIYTIMSAEEVANGKKSHWAELEISGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQDILNLYQDPDGTRKLLNFMLDNLAVHPEQLPPRPWITLKERDQILPSASFTVMCYNVLCDKYATRQLYGYCPSWALNWEYRKKGIMEEIVNCDADIISLQEVETEQYFTLFLPALKERGYDGFFSPKSRAKIMSEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQVAMANSDGSEAMLNRVMTKDNIGVAVVLEVHKELFGAGMKPIHAADKQLLIVANAHMHWDPEYSDVKLIQTMMFVSEVKNILEKASSRPGSPTADPNSIPLVLCADLNSLPDSGVVEYLSNGGVADNHKDFKELRYNECLMNFSCNGKNGSSEGRITHGFQLKSAYENNLMPYTNYTFDFKGVIDYIFYSKTHMNVLGVLGPLDPQWLVENNITGCPHPHIPSDHFSLLTQLELHPPLLPLVNGVHLPNRR
uniprot
proteins
ec_number
3.1.13.4
uniprot
proteins
function
FUNCTION: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence. {ECO:0000269|PubMed:17452450, ECO:0000269|PubMed:18377426, ECO:0000269|PubMed:21233283}.
uniprot
proteins
mass_dalton
63001
uniprot
proteins
mutagenesis
MUTAGEN 240; /note="E->A: Loss of deadenylase activity."; /evidence="ECO:0000269|PubMed:20628353, ECO:0000269|PubMed:27013054"; MUTAGEN 365; /note="P->A: Decreased deadenylase activity."; /evidence="ECO:0000269|PubMed:20628353"; MUTAGEN 410; /note="D->A: Loss of deadenylase activity."; /evidence="ECO:0000269|PubMed:17452450"; MUTAGEN 484; /note="F->A: Loss of deadenylase activity."; /evidence="ECO:0000269|PubMed:20628353"; MUTAGEN 489; /note="D->A: Loss of deadenylase activity."; /evidence="ECO:0000269|PubMed:17452450, ECO:0000269|PubMed:20628353"; MUTAGEN 529; /note="H->A: Loss of deadenylase activity."; /evidence="ECO:0000269|PubMed:17452450, ECO:0000269|PubMed:20628353
uniprot
proteins
protein_family
CCR4/nocturin family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17452450
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18377426
uniprot
proteins
pubmed
19558367
uniprot
proteins
pubmed
20628353
uniprot
proteins
pubmed
21233283
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
27013054
uniprot
proteins
pubmed
34611029
uniprot
proteins
sequence_length
555
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17452450, ECO:0000269|PubMed:21233283}. Nucleus {ECO:0000269|PubMed:21233283}. Note=Predominantly cytoplasmic. {ECO:0000269|PubMed:21233283}.
uniprot
proteins