Best2
entrez
212989
canonical
uniprot
Q8BGM5
canonical
ensembl
ENSMUSG00000052819
resolver
ensp
ENSMUSP00000053408
resolver
ensp
ENSMUSP00000147580
resolver
ensp
ENSMUSP00000147837
resolver
enst
ENSMUST00000059072
resolver
enst
ENSMUST00000209322
resolver
enst
ENSMUST00000209421
resolver
genesymbol
Best2
resolver
genesymbol_syn
Vmd2l1
resolver
uniprot
A0A0R4J0P0
resolver
uniprot
Q6H1U9
resolver
uniprot
Q8VCM0
resolver
uniprot_entry
A0A0R4J0P0_MOUSE
resolver
uniprot_entry
BEST2_MOUSE
resolver
uniprot_sec
Q6H1U9
resolver
uniprot_sec
Q8VCM0
resolver
activity_regulation
ACTIVITY REGULATION: Chloride channel activity is allosterically inhibited by GLUL/glutamine synthase (GS) which affects the gating at the aperture in the absence of intracellular glutamate. Inhibitory effect of GLUL is relieved upon increasing of intracellular level of L-glutamate. {ECO:0000250|UniProtKB:Q8NFU1}.
uniprot
proteins
amino_acid_sequence
MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEEQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFLDPAQGYKDHTLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEMYDDLAMLEKDLYWDAAEARAPYTAATAFLLQQPSFQGSTFDIALAKEDMQFQRLDGVDGPLGEVHGDFLQRLLPAGAGSVGPLGRRLSLLRRKNSCVSEASTAASCGCAGAADGGGVECGCGDPLLDPSLREPELEPPACPEPPAPIPGPTPEPFTTVSIPGPRAPAPPWLPSPIGEEEESPA
uniprot
proteins
function
FUNCTION: Ligand-gated anion channel that allows the movement of anions across cell membranes when activated by calcium (Ca2+) (PubMed:18400985, PubMed:20407206). Transports a large specter of anions, namely mediates the movement of chloride, L-glutamate and iodide (PubMed:18400985, PubMed:20407206). Calcium-binding triggers the dilation of the aperture, but calcium-dependent gating is only effective when the size of the passing anion is bigger than the closed aperture (By similarity). Mediates the calcium-activated hydrogencarbonate movement and participates in colonic hydrogencarbonate secretion concomitant with mucin secretion (PubMed:20407206). In non-pigmented epithelium (NPE), mediates the efflux of intracellular L-glutamate; binding of intracellular L-glutamate activates and open both the neck and the aperture of the channel, leading to L-glutamate exit promoting chloride influx movement from the extracellular side in trans (By similarity). Also exhibits a directional permeability for intracellular glutamine, in a similar manner as for L-glutamate (By similarity). {ECO:0000250|UniProtKB:E1BF86, ECO:0000250|UniProtKB:Q8NFU1, ECO:0000269|PubMed:18400985, ECO:0000269|PubMed:20407206}.
uniprot
proteins
mass_dalton
57023
uniprot
proteins
protein_family
Anion channel-forming bestrophin (TC 1.A.46) family
uniprot
proteins
protein_family
Calcium-sensitive chloride channel subfamily
uniprot
proteins
pubmed
15218265
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18400985
uniprot
proteins
pubmed
20407206
uniprot
proteins
sequence_length
508
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:E1BF86}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8NFU1}. Basolateral cell membrane {ECO:0000269|PubMed:20407206}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8NFU1}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..51; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q8NFU1"; TRANSMEM 61..82; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q8NFU1"; TRANSMEM 239..255; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q8NFU1"; TRANSMEM 275..288; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q8NFU1
uniprot
proteins