Macrod2
entrez
72899
canonical
uniprot
Q3UYG8
canonical
ensembl
ENSMUSG00000068205
resolver
ensp
ENSMUSP00000041780
resolver
ensp
ENSMUSP00000077174
resolver
ensp
ENSMUSP00000105690
resolver
ensp
ENSMUSP00000105691
resolver
ensp
ENSMUSP00000105694
resolver
ensp
ENSMUSP00000363733
resolver
ensp
ENSMUSP00000363734
resolver
enst
ENSMUST00000043836
resolver
enst
ENSMUST00000078027
resolver
enst
ENSMUST00000110063
resolver
enst
ENSMUST00000110064
resolver
genesymbol
Macrod2
resolver
uniprot
B1AW12
resolver
uniprot
F6XJ44
resolver
uniprot
Q9D117
resolver
uniprot_entry
B1AW12_MOUSE
resolver
uniprot_entry
F6XJ44_MOUSE
resolver
uniprot_entry
MACD2_MOUSE
resolver
uniprot_entry
Q9D117_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Subject to product inhibition by ADP-ribose. {ECO:0000250|UniProtKB:A1Z1Q3}.
uniprot
proteins
amino_acid_sequence
MYPSNKKKKVWREEKERLLKMTLEERRKEYIRDYVSLSTILSWKEEMKSKGQNDEENTQEAPQMKKSLSEKVSLYRGDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPCLLAECRNLNGCETGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYQSSLKLVKENNLRSVAFPCISTGIYGFPNEPAAVIALGTIKEWLAKNHQEVDRIIFCVFLEVDFKIYKKKMNEFFPVDDNNEGTDADMKEDSEGPEPKGLSPPHKKSKAKKPESSKDSSEDESGPEEKQTAEEMEGQSQEAGGLRFLLRNLLGLIHRDGVNTTPVPSPASEDKAEVHKDEDSAKDDNTVKDSDMTNHSVCDQELPNGQENDSAKSEGKTEAESPSSSMETEDLSPNQEDAAIVEQPEVIPLIDDQEAQEGGEAQGKDAPAVFAESQGSSEAENTSGPDVDMNSQVDGVNEPTESLQEDLQ
uniprot
proteins
ec_number
3.2.2.-
uniprot
proteins
ec_number
3.5.1.-
uniprot
proteins
function
FUNCTION: Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. {ECO:0000250|UniProtKB:A1Z1Q3}.
uniprot
proteins
mass_dalton
52145
uniprot
proteins
protein_family
MacroD-type family
uniprot
proteins
protein_family
MacroD1/2-like subfamily
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17586838
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
475
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:A1Z1Q3}. Note=Recruited to DNA lesions, probably via mono-APD-ribosylated proteins. {ECO:0000250|UniProtKB:A1Z1Q3}.
uniprot
proteins