Atxn7
entrez
246103
canonical
uniprot
Q8R4I1
canonical
ensembl
ENSMUSG00000021738
resolver
ensp
ENSMUSP00000022257
resolver
ensp
ENSMUSP00000152934
resolver
ensp
ENSMUSP00000153613
resolver
ensp
ENSMUSP00000168843
resolver
enst
ENSMUST00000022257
resolver
enst
ENSMUST00000223714
resolver
enst
ENSMUST00000223880
resolver
genesymbol
Atxn7
resolver
genesymbol_syn
Sca7
resolver
uniprot
A0A286YDW9
resolver
uniprot
E9QPX9
resolver
uniprot
Q8BL17
resolver
uniprot_entry
A0A286YDW9_MOUSE
resolver
uniprot_entry
ATX7_MOUSE
resolver
uniprot_sec
E9QPX9
resolver
uniprot_sec
Q8BL17
resolver
amino_acid_sequence
MSERAADDVRGEPRRAAGGAAAARQQQQQPQPLQPQRQHPPLRRPRAEDGGTGDTTTSAAAMATVGERRPLPSPEAMLGQSWNLWVEASKLPGKDGTELDESFKEFGKNREVMGLCREDMPIFGLCPAHDDFYLVVCNDCNQVVKPQAFQSHYERRHSSSSKPALAVPHTSVFSLLPSLSKSKGSGAGGSSRPPSGGVLCASSSSKLLRLPKEKLPLRGNMKPMHPVQQIKVPHGRVMTPSVKVEKMHPKMDGTLLKSTVGPACPATMSSAVKPGLNCPSIPKPTLPSPGQILNGKGLPAMPTLEKKSEDSSNNRKFLNKRLSEREFDPDIHCGVIDLDTKKPCTRSLTCKTHSLTQRRAVQGRRKRFDVLLAEHKNKAREKELIRHDSQQVPHPLRDPHPTPPRTPQEPQLPAESKPFLASKPKPQTPSLPRPPGCPAQQGGSTPIDPPPGQESPHPPLPATEPASRLSSEEGEGDDREESVEKLDCHYSGRHPQPASFCTFGSRQIGRGYYVFDSRWNRLRCALNLMVEKHLNAQLWKKIPPVPCTTSPVSARVPHRTNSVPTSQGGISYLAATTVSAPPVLLSSTCISPNSKSVPAHGTTLNAQPAGSGAMDPVCSVQSRQVSASSSPPSTPSGLSSVPSSPLSRKPQKWKPSKSIRPKESSALSTNCHNASSSTSGGSGKKRKNSSPLLVPSSSSSSSSSSSSSHSVNSFRKNCVAHSGTPYLSTAPSSHSIGLNCVTNKTHSVSLRHEQAGRGPAGVSSAEPIKRMSVMVNSSDSTLSLGPFIHQASELPVNPHSHTPLDKLIGKKRKCSPGSSTVGNSGSKPTKVAKLPAMNNVHMKHTGNISGAQGLTNNSLLHQPKARP
uniprot
proteins
function
FUNCTION: Acts as a component of the SAGA (aka STAGA) transcription coactivator-HAT complex (By similarity). Mediates the interaction of SAGA complex with the CRX and is involved in CRX-dependent gene activation (By similarity). Probably involved in tethering the deubiquitination module within the SAGA complex (By similarity). Necessary for microtubule cytoskeleton stabilization (By similarity). Involved in neurodegeneration (Probable). {ECO:0000250|UniProtKB:O15265, ECO:0000305|PubMed:11580893}.
uniprot
proteins
mass_dalton
92697
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved by caspase-7 (CASP7). {ECO:0000250|UniProtKB:O15265}.; PTM: Sumoylation has no effect on subcellular location or interaction with components of the STAGA complex. {ECO:0000250|UniProtKB:O15265}.
uniprot
proteins
protein_family
Ataxin-7 family
uniprot
proteins
pubmed
11580893
uniprot
proteins
pubmed
12039035
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
867
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O15265}. Nucleus, nucleolus {ECO:0000250|UniProtKB:O15265}. Nucleus matrix {ECO:0000250|UniProtKB:O15265}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O15265}. Note=In addition to a diffuse distribution throughout the nucleus, it is associated with the nuclear matrix and the nucleolus. It is able to shuttle between the nucleus and cytoplasm (By similarity). {ECO:0000250|UniProtKB:O15265}.
uniprot
proteins