DUS3L
entrez
56931
canonical
uniprot
Q96G46
canonical
ensembl
ENSG00000141994
resolver
ensp
ENSP00000311977
resolver
ensp
ENSP00000315558
resolver
ensp
ENSP00000628773
resolver
ensp
ENSP00000726636
resolver
genesymbol
DUS3L
resolver
hgnc
HGNC:26920
resolver
uniprot
B2RDV7
resolver
uniprot
Q96HM5
resolver
uniprot
Q9BSU4
resolver
uniprot
Q9H877
resolver
uniprot
Q9NPR1
resolver
uniprot_entry
B2RDV7_HUMAN
resolver
uniprot_entry
DUS3L_HUMAN
resolver
uniprot_sec
Q96HM5
resolver
uniprot_sec
Q9BSU4
resolver
uniprot_sec
Q9H877
resolver
uniprot_sec
Q9NPR1
resolver
amino_acid_sequence
MAEGTAEAPLENGGGGDSGAGALERGVAPIKRQYLTTKEQFHQFLEAKGQEKTCRETEVGDPAGNELAEPEAKRIRLEDGQTADGQTEEAAEPGEQLQTQKRARGQNKGRPHVKPTNYDKNRLCPSLIQESAAKCFFGDRCRFLHDVGRYLETKPADLGPRCVLFETFGRCPYGVTCRFAGAHLRPEGQNLVQEELAARGTQPPSIRNGLDKALQQQLRKREVRFERAEQALRRFSQGPTPAAAVPEGTAAEGAPRQENCGAQQVPAGPGTSTPPSSPVRTCGPLTDEDVVRLRPCEKKRLDIRGKLYLAPLTTCGNLPFRRICKRFGADVTCGEMAVCTNLLQGQMSEWALLKRHQCEDIFGVQLEGAFPDTMTKCAELLSRTVEVDFVDINVGCPIDLVYKKGGGCALMNRSTKFQQIVRGMNQVLDVPLTVKIRTGVQERVNLAHRLLPELRDWGVALVTLHGRSREQRYTKLADWQYIEECVQAASPMPLFGNGDILSFEDANRAMQTGVTGIMIARGALLKPWLFTEIKEQRHWDISSSERLDILRDFTNYGLEHWGSDTQGVEKTRRFLLEWLSFLCRYVPVGLLERLPQRINERPPYYLGRDYLETLMASQKAADWIRISEMLLGPVPPSFAFLPKHKANAYK
uniprot
proteins
ec_number
1.3.1.-
uniprot
proteins
ec_number
1.3.1.89
uniprot
proteins
function
FUNCTION: Catalyzes the synthesis of dihydrouridine, a modified base, in various RNAs, such as tRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:34556860). Mainly modifies the uridine in position 47 (U47) in the D-loop of most cytoplasmic tRNAs (PubMed:34556860). Also able to mediate the formation of dihydrouridine in some mRNAs, thereby regulating their translation (PubMed:34556860). {ECO:0000269|PubMed:34556860}.
uniprot
proteins
mass_dalton
72594
uniprot
proteins
mutagenesis
MUTAGEN 396; /note="C->A: Abolished synthesis of dihydrouridine."; /evidence="ECO:0000269|PubMed:34556860
uniprot
proteins
protein_family
Dus family
uniprot
proteins
protein_family
Dus3 subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
34556860
uniprot
proteins
sequence_length
650
uniprot
proteins