Pias2
entrez
17344
canonical
uniprot
Q8C5D8
canonical
ensembl
ENSMUSG00000025423
resolver
ensp
ENSMUSP00000110424
resolver
ensp
ENSMUSP00000110425
resolver
ensp
ENSMUSP00000131485
resolver
ensp
ENSMUSP00000226463
resolver
ensp
ENSMUSP00000226464
resolver
ensp
ENSMUSP00000226465
resolver
ensp
ENSMUSP00000226479
resolver
ensp
ENSMUSP00000226480
resolver
ensp
ENSMUSP00000226481
resolver
enst
ENSMUST00000114776
resolver
enst
ENSMUST00000168882
resolver
genesymbol
Pias2
resolver
genesymbol_syn
Miz1
resolver
genesymbol_syn
Piasx
resolver
uniprot
F8WHS8
resolver
uniprot
G3UWE3
resolver
uniprot
O54987
resolver
uniprot
Q3V3U5
resolver
uniprot
Q8C384
resolver
uniprot
Q8CDQ8
resolver
uniprot
Q8K208
resolver
uniprot
Q99JX5
resolver
uniprot
Q9D5W7
resolver
uniprot
Q9QZ63
resolver
uniprot_entry
F8WHS8_MOUSE
resolver
uniprot_entry
G3UWE3_MOUSE
resolver
uniprot_entry
PIAS2_MOUSE
resolver
uniprot_entry
Q3V3U5_MOUSE
resolver
uniprot_sec
O54987
resolver
uniprot_sec
Q8C384
resolver
uniprot_sec
Q8CDQ8
resolver
uniprot_sec
Q8K208
resolver
uniprot_sec
Q99JX5
resolver
uniprot_sec
Q9D5W7
resolver
uniprot_sec
Q9QZ63
resolver
amino_acid_sequence
MADFEELRNMVSSFRVSELQVLLGFAGRNKSGRKHDLLMRALHLLKSGCSPAVQIKIRELYRRRYPRTLEGLCDLSTIKSSVFSLDGSSSPVEPDLPVAGIHSLPSTSITPHSPSSPVGSVLLQDTKPTFEMQQPSPPIPPVHPDVQLKNLPFYDVLDVLIKPTSLVQSSIQRFQEKFFIFALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAVPNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLTADPDSEIATTSLRVSLMCPLGKMRLTIPCRAVTCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDCSDVDEIKFQEDGSWCPMRPKKEAMKVTSQPCTKVESSSVFSKPCSVTVASDASKKKIDVIDLTIESSSDEEEDPPAKRKCIFMSETQSSPTKGVLMYQPSSVRVPSVTSVDPAAIPPSLTDYSVPFHHTPVSSMSSDLPGLDFLSLIPVDPQYCPPMFLDSLTSPLTASSTSVTTTSPHESSTHVSSSSSRSETGVITSSGRNIPDIISLD
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway and the steroid hormone signaling pathway. The effects of this transcriptional coregulation, transactivation or silencing may vary depending upon the biological context and PIAS2 isoform studied. However, it seems to be mostly involved in gene silencing. Binds to sumoylated ELK1 and enhances its transcriptional activity by preventing recruitment of HDAC2 by ELK1, thus reversing SUMO-mediated repression of ELK1 transactivation activity. Isoform PIASx-beta, but not isoform PIASx-alpha, promotes MDM2 sumoylation. Isoform PIASx-alpha promotes PARK7 sumoylation. Isoform PIASx-beta promotes NCOA2 sumoylation more efficiently than isoform PIASx-alpha (By similarity). Sumoylates PML at'Lys-65' and 'Lys-160' (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
68426
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein sumoylation.
uniprot
proteins
post_translational_modification
PTM: Sumoylated. {ECO:0000269|PubMed:12077349}.
uniprot
proteins
protein_family
PIAS family
uniprot
proteins
pubmed
11104669
uniprot
proteins
pubmed
12077349
uniprot
proteins
pubmed
12193603
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15767674
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9256341
uniprot
proteins
sequence_length
621
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:12077349}. Nucleus, PML body {ECO:0000250|UniProtKB:O75928}. Nucleus {ECO:0000269|PubMed:12193603}. Note=Colocalizes at least partially with promyelocytic leukemia nuclear bodies (PML NBs) (By similarity). Colocalizes with SUMO1 in nuclear granules (PubMed:12077349). {ECO:0000250|UniProtKB:O75928, ECO:0000269|PubMed:12077349}.
uniprot
proteins