Tmprss12
entrez
75002
canonical
uniprot
Q3V0Q7
canonical
ensembl
ENSMUSG00000045631
resolver
ensp
ENSMUSP00000093914
resolver
enst
ENSMUST00000096200
resolver
genesymbol
Tmprss12
resolver
uniprot_entry
TMPSC_MOUSE
resolver
amino_acid_sequence
MASWALSAALLCLGGAFAYSELHSLSLREGSALGQATVPGPPEEEQPVTKDCGIAPLRGAVEGSRIIGGSQADTGAWPWQVSLQVQDGDILMHVCGGALVRDRWVLTAAHCTKEARDPLKWRAVMGTNDLTRSPYHSRNIRITDIIIPPDFIMETFVNDIALFRLKRAVRYNDYIQPICLPFGVFQKLDQNTACFISGWGRTREEGNGTTILQEAKVHFISREVCSSDQGYSGMIPNTSFCAGHENGTFDSCRGDSGGPLMCYLPEHSRYFVMGITSYGHGCGRRHFPGVYSNPSFFQEWMTHYLSQGNINRLFNMDIVLGQVLTALGSVILLGVT
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Required for male fertility (PubMed:32529245, PubMed:35547804). Plays a critical role in sperm capacitation and acrosome reactions during fertilization, and also plays a role in the regulation of proteins involved in spermatogenesis (PubMed:35547804). Regulates protein pathways that promote chromosomal synapsis formation, double-strand break repair, formation of the inner mitochondrial membrane cristae and apoptosis in developing sperm (PubMed:35547804). Required for normal sperm motility and binding to the zona pellucida, potentially via a role in ADAM3 protein maturation (PubMed:32529245). {ECO:0000269|PubMed:32529245, ECO:0000269|PubMed:35547804}.
uniprot
proteins
mass_dalton
36916
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32529245
uniprot
proteins
pubmed
35547804
uniprot
proteins
sequence_length
336
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q86WS5}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:32529245, ECO:0000269|PubMed:35547804}. Note=Expression in the acrosome decreases after acrosome reaction. {ECO:0000269|PubMed:32529245}.
uniprot
proteins
transmembrane_region
TRANSMEM 313..333; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins