Mtln
entrez
67885
canonical
uniprot
Q8BT35
canonical
ensembl
ENSMUSG00000051319
resolver
ensp
ENSMUSP00000141107
resolver
enst
ENSMUST00000135091
resolver
genesymbol
Mtln
resolver
genesymbol_syn
Lemp
resolver
genesymbol_syn
Moxi
resolver
genesymbol_syn
Mpm
resolver
genesymbol_syn
Smim37
resolver
uniprot_entry
MTLN_MOUSE
resolver
amino_acid_sequence
MADVSERTLQVSVLVAFASGVVLGWQANRLRRRYLDWRKRRLQDKLATTQKKLDLA
uniprot
proteins
function
FUNCTION: Positively regulates mitochondrial complex assembly and/or stability (PubMed:29949756). Increases mitochondrial membrane potential while decreasing mitochondrial reactive oxygen species (By similarity). Increases mitochondrial respiration rate (PubMed:31296841). Increased mitochondrial respiratory activity promotes myogenic differentiation which facilitates muscle growth and regeneration (PubMed:31296841, PubMed:32393776). Increases mitochondrial calcium retention capacity (PubMed:29949756). Plays a role in maintenance of cellular lipid composition through its interaction with cytochrome b5 reductase CYB5R3 which is required for mitochondrial respiratory complex I activity (PubMed:30796188). Interacts with the mitochondrial trifunctional enzyme complex (MTE) and enhances fatty acid beta-oxidation (PubMed:29949755, PubMed:32243843). Not required for MTE formation or stability (PubMed:29949755). Modulates triglyceride clearance in adipocytes through its role in regulating fatty acid beta-oxidation and lipolysis (PubMed:32243843). {ECO:0000250|UniProtKB:Q8NCU8, ECO:0000269|PubMed:29949755, ECO:0000269|PubMed:29949756, ECO:0000269|PubMed:30796188, ECO:0000269|PubMed:31296841, ECO:0000269|PubMed:32243843, ECO:0000269|PubMed:32393776}.
uniprot
proteins
mass_dalton
6529
uniprot
proteins
protein_family
Mitoregulin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
29949755
uniprot
proteins
pubmed
29949756
uniprot
proteins
pubmed
30796188
uniprot
proteins
pubmed
31296841
uniprot
proteins
pubmed
32243843
uniprot
proteins
pubmed
32393776
uniprot
proteins
sequence_length
56
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:29949755, ECO:0000269|PubMed:29949756, ECO:0000269|PubMed:30796188, ECO:0000269|PubMed:31296841, ECO:0000269|PubMed:32393776}; Single-pass membrane protein {ECO:0000305}. Note=Preferentially binds to cardiolipin relative to other common cell membrane lipids. {ECO:0000269|PubMed:29949756}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..27; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins