Rnf152
entrez
293561
canonical
uniprot
D4A723
canonical
ensembl
ENSRNOG00000014859
resolver
ensembl
ENSRNOG00055011595
resolver
ensembl
ENSRNOG00060008876
resolver
ensembl
ENSRNOG00065013881
resolver
ensp
ENSRNOP00000019921
resolver
ensp
ENSRNOP00000091301
resolver
ensp
ENSRNOP00000093523
resolver
ensp
ENSRNOP00000093936
resolver
ensp
ENSRNOP00000095982
resolver
ensp
ENSRNOP00000097172
resolver
ensp
ENSRNOP00000099755
resolver
ensp
ENSRNOP00000102165
resolver
ensp
ENSRNOP00000105596
resolver
ensp
ENSRNOP00000109601
resolver
ensp
ENSRNOP00055015878
resolver
ensp
ENSRNOP00055015880
resolver
ensp
ENSRNOP00055015882
resolver
ensp
ENSRNOP00055015884
resolver
ensp
ENSRNOP00055015887
resolver
ensp
ENSRNOP00060011512
resolver
ensp
ENSRNOP00060011520
resolver
ensp
ENSRNOP00060011533
resolver
ensp
ENSRNOP00060011541
resolver
ensp
ENSRNOP00060011546
resolver
ensp
ENSRNOP00065017771
resolver
ensp
ENSRNOP00065017774
resolver
ensp
ENSRNOP00065017778
resolver
ensp
ENSRNOP00065017780
resolver
ensp
ENSRNOP00065017782
resolver
enst
ENSRNOT00000019921
resolver
enst
ENSRNOT00000102604
resolver
enst
ENSRNOT00000105259
resolver
enst
ENSRNOT00000105662
resolver
enst
ENSRNOT00000107961
resolver
enst
ENSRNOT00000119715
resolver
enst
ENSRNOT00000132425
resolver
enst
ENSRNOT00000149140
resolver
enst
ENSRNOT00000164598
resolver
enst
ENSRNOT00000166733
resolver
enst
ENSRNOT00055019687
resolver
enst
ENSRNOT00055019689
resolver
enst
ENSRNOT00055019691
resolver
enst
ENSRNOT00055019693
resolver
enst
ENSRNOT00055019696
resolver
enst
ENSRNOT00060014865
resolver
enst
ENSRNOT00060014873
resolver
enst
ENSRNOT00060014886
resolver
enst
ENSRNOT00060014895
resolver
enst
ENSRNOT00060014899
resolver
enst
ENSRNOT00065022879
resolver
enst
ENSRNOT00065022882
resolver
enst
ENSRNOT00065022886
resolver
enst
ENSRNOT00065022888
resolver
enst
ENSRNOT00065022890
resolver
genesymbol
Rnf152
resolver
uniprot_entry
RN152_RAT
resolver
amino_acid_sequence
METLSQDSLLECQICFNYYSPRRRPKLLDCKHTCCSVCLQQMRTSQKDVRCPWCRGITKLPPGFSVSQLPDDPEVLAVIAIPHTSEHTPVFIKLPSNGCYMLPLPISKERTLLPGDMGCRLLPGSQQKSLTVVTIPAEQQPLQGGAPQEAVEEEPDRRGVAKSSTWSGVCTVILVACVLVFLLGIVLHNMSCISKRFTVISCG
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that acts as a negative regulator of mTORC1 signaling by mediating ubiquitination of RagA/RRAGA and RHEB. Catalyzes 'Lys-63'-linked polyubiquitination of RagA/RRAGA in response to amino acid starvation, thereby regulating mTORC1 signaling. Also mediates monoubiquitination of RHEB, promoting its association with the TSC-TBC complex and subsequent inhibition. Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed. {ECO:0000250|UniProtKB:Q8N8N0}.
uniprot
proteins
mass_dalton
22356
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q8N8N0}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Autoubiquitinated in vitro, leading to its degradation by the proteasome. {ECO:0000250|UniProtKB:Q8N8N0}.
uniprot
proteins
protein_family
RNF152 family
uniprot
proteins
sequence_length
203
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q8N8N0}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q8N8N0}.
uniprot
proteins
transmembrane_region
TRANSMEM 167..187; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins