Fbxw8
entrez
231672
canonical
uniprot
Q8BIA4
canonical
ensembl
ENSMUSG00000032867
resolver
ensp
ENSMUSP00000047012
resolver
genesymbol
Fbxw8
resolver
uniprot
Q8BI62
resolver
uniprot
Q8BI75
resolver
uniprot
Q8BI76
resolver
uniprot
Q8CID8
resolver
uniprot
Q921Z1
resolver
uniprot_entry
FBXW8_MOUSE
resolver
uniprot_sec
Q8BI62
resolver
uniprot_sec
Q8BI75
resolver
uniprot_sec
Q8BI76
resolver
uniprot_sec
Q8CID8
resolver
uniprot_sec
Q921Z1
resolver
amino_acid_sequence
MDDHNLEEFRRHWQEELAQSQALRRRRRLEAGERRSPRRPEAGARGEPASGYLGLAQGLLEGAGRPPAPRPGRGGDRKDTSSRSRSPPDRDATEPEPLVDQLIRDLNELDDVPFFDVRLPYELAINIFQYLNRRELGLCAQVSKTWKVIAEDEVLWYRLCRQEGHLPHSRFSDYTCWKLILQECLAKEHTLRANWKNRKGAVSELEHVPDAVLCDVRSHDGVVIAGYTSGDVRVWDTRTWDYVAPFLESESEEEDPGMQPYVSFVRINSSLAVAAYEDGILNIWDLRTGRFPIFRFEHDARIQALALSQEKPIVATASAFDVVMLYPNEEGHWHVASEFEVQKLVDYLEIVPNTGRYPVAIATAGDLVYLLKADDSARTLHYVYGQPATCLDVSASQVAFGVKSLGWVYEGNKILVYSLEAERCLSKLGNALGDFTCVNIRDSPPNLMVSGNMDRRVRIHDLRSDKIALSLSAHQLGVSAVQMDDWKVVSGGEEGLVSVWDYRMNQKLWEVHSRHPVRYLSFNSHSLITANVPYEKVLRNSDLDNFACHRRHRGLIHAYEFAVDQLAFQSPLPVCRLPRDIMAGYSYDLALSFPHDSI
uniprot
proteins
function
FUNCTION: Substrate-recognition component of the Cul7-RING(FBXW8) ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain (By similarity). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner: the Cul7-RING(FBXW8) complex recognizes and binds IRS1 previously phosphorylated by S6 kinase (RPS6KB1 or RPS6KB2) (PubMed:23142081). The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation (By similarity). The Cul7-RING(FBXW8) complex also mediates ubiquitination of phosphorylated cyclin-D1 (CCND1) (By similarity). The Cul7-RING(FBXW8) complex is however not a major regulator of CCND1 stability during the G1/S transition (PubMed:22124152). Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (By similarity). {ECO:0000250|UniProtKB:Q8N3Y1, ECO:0000269|PubMed:22124152, ECO:0000269|PubMed:23142081}.
uniprot
proteins
mass_dalton
67956
uniprot
proteins
mutagenesis
MUTAGEN 86; /note="S->A: Abolished phosphorylation by mTORC2, leading to increased protein turnover."; /evidence="ECO:0000269|PubMed:23142081
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:23142081}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-86 by mTORC2 promotes FBXW8 stabilization, allowing its translocation to the cytosol in response to insulin. {ECO:0000269|PubMed:23142081}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16880526
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17998335
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22124152
uniprot
proteins
pubmed
23142081
uniprot
proteins
pubmed
29153991
uniprot
proteins
sequence_length
598
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P0DL28}. Golgi apparatus {ECO:0000250|UniProtKB:P0DL28}. Cytoplasm, cytosol {ECO:0000269|PubMed:23142081}. Note=Localizes to the cytosol when phosphorylated at Ser-86, promoting IRS1 ubiquitination. {ECO:0000269|PubMed:23142081}.
uniprot
proteins