Padi4
entrez
29512
canonical
uniprot
O88807
canonical
ensembl
ENSRNOG00000006855
resolver
ensembl
ENSRNOG00065023578
resolver
ensp
ENSRNOP00000009081
resolver
ensp
ENSRNOP00000099571
resolver
ensp
ENSRNOP00000100592
resolver
ensp
ENSRNOP00065032842
resolver
enst
ENSRNOT00000132511
resolver
enst
ENSRNOT00000133152
resolver
enst
ENSRNOT00065040343
resolver
genesymbol
Padi4
resolver
genesymbol_syn
Pad4
resolver
genesymbol_syn
Pdi4
resolver
uniprot
A0ABK0KXP7
resolver
uniprot
A0ABK0KZ72
resolver
uniprot
O35117
resolver
uniprot_entry
A0ABK0KXP7_RAT
resolver
uniprot_entry
A0ABK0KZ72_RAT
resolver
uniprot_entry
PADI4_RAT
resolver
uniprot_sec
O35117
resolver
amino_acid_sequence
MAQGAVIHVAPEEPTHAVCVVGTATPLDIRGSAPRGSTSFSITASPEVVVDVIHGPPSKKSTTGASKWPLDPKLEVTLQMKAASSRIDDQKVRISYYGPKTSSTQALLYLTGVELSLSADVTRTGKAKPAPAGKDQSTWTWGPDGHGAILLVNCDKEDPKSSGMDFEDDKVLDNKDLQDMSPMTLSTKTPKDFFDKYQLVLQVPKAKMNKVRVFRATRGKLPSRYKVVLGPQQFSHRLELLGGQHSTDFYVEGLAFPDADFKGLIPLTISLLDKSNPELPEALVFQDTVMFRVAPWIMTPNTQPPQEVYVCRFSDNEDFLKSLATFTKKAKCKLTVCPEEENQDDQWMQDEMEIGYIQAPHKTLPVVFDSPRDRGLKDFPVKRVMGPNFGYVTRGLYRAEVTGLDAFGNLEVSPPVTVRGKEYPLGRILIGSSGYSSSESRDMHQILQDFLGAQQVQAPVRLFSDWLFVGHVDEFLSFVPARGKQGFRLLLSSPRACYQMFQELQTEGHGEASLFEGLKRKRQTISDILSSQKLRDQNAYVESCIDWNREVLKRELGLTEGDIIDIPQLFRIVGNSRGNPKAEAFFPNMVNMLVLGKHLGIPKPFGPIINGRCCLEEKVCSLLEPLGLHCTFINDFYSYHMYHGEVHCGTNVRRKPFAFKWWHMVP
uniprot
proteins
ec_number
3.5.3.15
uniprot
proteins
function
FUNCTION: Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54' (to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26' (to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3' (to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1 (H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Involved for the formation of neutrophil extracellular traps (NETs) by mediating citrullination of histone H3 and initiating decondensation of chromatin and nuclear membrane rupture. NETs are mainly composed of DNA fibers and are released by neutrophils to trap pathogens during inflammation. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1. {ECO:0000250|UniProtKB:Q9UM07}.
uniprot
proteins
mass_dalton
74467
uniprot
proteins
post_translational_modification
PTM: Autocitrullination at Arg-372 and Arg-374 inactivates the enzyme. {ECO:0000250|UniProtKB:Q9UM07}.
uniprot
proteins
protein_family
Protein arginine deiminase family
uniprot
proteins
pubmed
9675292
uniprot
proteins
pubmed
9738944
uniprot
proteins
sequence_length
666
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UM07}. Nucleus {ECO:0000250|UniProtKB:Q9UM07}. Cytoplasmic granule {ECO:0000250|UniProtKB:Q9UM07}. Note=Cytoplasmic granules of eosinophils and neutrophils. {ECO:0000250|UniProtKB:Q9UM07}.
uniprot
proteins