Ackr5
entrez
11536
canonical
uniprot
P43142
canonical
ensembl
ENSMUSG00000058396
resolver
ensp
ENSMUSP00000100882
resolver
genesymbol
Ackr5
resolver
genesymbol_syn
Admr
resolver
genesymbol_syn
Gpcr22
resolver
genesymbol_syn
Gpr182
resolver
uniprot
G3X9R9
resolver
uniprot_entry
ACKR5_MOUSE
resolver
uniprot_sec
G3X9R9
resolver
amino_acid_sequence
MSVIPSPRPVSTLEPDNDFRDIHNWTELLHLFNQTFTDCHIEFNENTKHVVLFVFYLAIFVVGLVENVLVICVNCRRSGRVGMLNLYILNMAIADLGIILSLPVWMLEVMLEYTWLWGSFSCRFIHYFYLVNMYSSIFFLTCLSIDRYVTLTNTSPSWQRHQHRIRRAVCAGVWVLSAIIPLPEVVHIQLLDGSEPMCLFLAPFETYSAWALAVALSATILGFLLPFLLIAVFNILTACRLRRQRQTESRRHCLLMWAYIVVFAICWLPYQVTMLLLTLHGTHIFLHCHLVNLLYFFYEIIDCFSMLHCVANPILYNFLSPSFRGRLLSLVVRYLPKEQARAAGGRASSSSSTQHSIIITKEGSLPAAADLHTHPIRNVQASSPPPNTSPTLCNSVAS
uniprot
proteins
function
FUNCTION: Atypical chemokine receptor that regulates chemokine levels and localization through chemokine binding, independently of activating classical ligand-induced signaling pathways such as G protein activation and Ca(2+) mobilization (PubMed:33875597, PubMed:35013216, PubMed:37554323, PubMed:38026988). Instead, it mediates chemokine sequestration, transport, or internalization to control their availability (PubMed:33875597, PubMed:35013216, PubMed:37554323, PubMed:38026988). Acts as a scavenger for a broad range of chemokines from CXC, CC and XC chemokine ligand families including CXCL9, CXCL10, CXCL12, CXCL13, CXCL11, CXCL14, CCL1, CCL11, CCL19, CCL25, CCL28 and CCL22, CCL24 and CCL27 (PubMed:33875597, PubMed:35013216, PubMed:37554323, PubMed:38026988). Is the only atypical receptor for chemokines CXCL13 and CCL28 (PubMed:37554323). Has a strong constitutive association with beta-arrestins, which is essential for intracellular receptor trafficking and chemokine scavenging, and occurs independently of ligand binding (PubMed:37554323). Cooperates with ACKR3 and ACKR4 in regulating serum levels of CXCL12 and CCL19, respectively (PubMed:37554323). Acts as an important modulator of cellular immunity (PubMed:37554323). {ECO:0000269|PubMed:33875597, ECO:0000269|PubMed:35013216, ECO:0000269|PubMed:37554323, ECO:0000269|PubMed:38026988}.
uniprot
proteins
mass_dalton
45384
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
33875597
uniprot
proteins
pubmed
35013216
uniprot
proteins
pubmed
37554323
uniprot
proteins
pubmed
38026988
uniprot
proteins
pubmed
8288218
uniprot
proteins
sequence_length
398
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:37554323}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:37554323}; Multi-pass membrane protein {ECO:0000255}. Note=Spontaneously traffics between the plasma membrane and endosomes, in a beta-arrestin-dependent manner. {ECO:0000269|PubMed:37554323}.
uniprot
proteins
transmembrane_region
TRANSMEM 54..75; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 87..109; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 124..145; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 167..189; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 214..235; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 255..276; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 296..316; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins