ECD
entrez
11319
canonical
uniprot
O95905
canonical
ensembl
ENSG00000122882
resolver
ensp
ENSP00000362070
resolver
ensp
ENSP00000395786
resolver
ensp
ENSP00000401566
resolver
genesymbol
ECD
resolver
hgnc
HGNC:17029
resolver
uniprot
C9JX46
resolver
uniprot
E9PAW8
resolver
uniprot_entry
ECD_HUMAN
resolver
uniprot_sec
C9JX46
resolver
uniprot_sec
E9PAW8
resolver
amino_acid_sequence
MEETMKLATMEDTVEYCLFLIPDESRDSDKHKEILQKYIERIITRFAPMLVPYIWQNQPFNLKYKPGKGGVPAHMFGVTKFGDNIEDEWFIVYVIKQITKEFPELVARIEDNDGEFLLIEAADFLPKWLDPENSTNRVFFCHGELCIIPAPRKSGAESWLPTTPPTIPQALNIITAHSEKILASESIRAAVNRRIRGYPEKIQASLHRAHCFLPAGIVAVLKQRPRLVAAAVQAFYLRDPIDLRACRVFKTFLPETRIMTSVTFTKCLYAQLVQQRFVPDRRSGYRLPPPSDPQYRAHELGMKLAHGFEILCSKCSPHFSDCKKSLVTASPLWASFLESLKKNDYFKGLIEGSAQYRERLEMAENYFQLSVDWPESSLAMSPGEEILTLLQTIPFDIEDLKKEAANLPPEDDDQWLDLSPDQLDQLLQEAVGKKESESVSKEEKEQNYDLTEVSESMKAFISKVSTHKGAELPREPSEAPITFDADSFLNYFDKILGPRPNESDSDDLDDEDFECLDSDDDLDFETHEPGEEASLKGTLDNLKSYMAQMDQELAHTCISKSFTTRNQVEPVSQTTDNNSDEEDSGTGESVMAPVDVDLNLVSNILESYSSQAGLAGPASNLLQSMGVQLPDNTDHRPTSKPTKN
uniprot
proteins
function
FUNCTION: Regulator of p53/TP53 stability and function. Inhibits MDM2-mediated degradation of p53/TP53 possibly by cooperating in part with TXNIP (PubMed:16849563, PubMed:23880345). May be involved transcriptional regulation. In vitro has intrinsic transactivation activity enhanced by EP300. May be a transcriptional activator required for the expression of glycolytic genes (PubMed:19919181, PubMed:9928932). Involved in regulation of cell cycle progression. Proposed to disrupt Rb-E2F binding leading to transcriptional activation of E2F proteins (PubMed:19640839). The cell cycle -regulating function may depend on its RUVBL1-mediated association with the R2TP complex (PubMed:26711270). May play a role in regulation of pre-mRNA splicing (PubMed:24722212). Participates together with DDX39A in mRNA nuclear export (PubMed:33941617). {ECO:0000269|PubMed:16849563, ECO:0000269|PubMed:19640839, ECO:0000269|PubMed:19919181, ECO:0000269|PubMed:23880345, ECO:0000269|PubMed:26711270, ECO:0000269|PubMed:33941617, ECO:0000305|PubMed:24722212, ECO:0000305|PubMed:9928932}.
uniprot
proteins
mass_dalton
72758
uniprot
proteins
mutagenesis
MUTAGEN 481; /note="I->A: Decreases transactivation activity."; /evidence="ECO:0000269|PubMed:19919181"; MUTAGEN 484; /note="D->F: Decreases transactivation activity."; /evidence="ECO:0000269|PubMed:19919181"; MUTAGEN 489; /note="L->A: Decreases transactivation activity."; /evidence="ECO:0000269|PubMed:19919181"; MUTAGEN 503; /note="S->A: Greatly impairs in vitro phosphorylation by CK2 and impairs cell cycle regulation activity; when associated with A-505, A-518, A-572, A-579 and A-584."; /evidence="ECO:0000269|PubMed:26711270"; MUTAGEN 505; /note="S->A: Greatly impairs in vitro phosphorylation by CK2 and impairs cell cycle regulation activity; when associated with A-503, A-518, A-572, A-579 and A-584."; /evidence="ECO:0000269|PubMed:26711270"; MUTAGEN 510; /note="D->R: Increases transactivation activity."; /evidence="ECO:0000269|PubMed:19919181"; MUTAGEN 512; /note="D->R: Increases transactivation activity."; /evidence="ECO:0000269|PubMed:19919181"; MUTAGEN 518; /note="S->A: Greatly impairs in vitro phosphorylation by CK2 and impairs cell cycle regulation activity; when associated with A-503, A-505, A-572, A-579 and A-584."; /evidence="ECO:0000269|PubMed:26711270"; MUTAGEN 520; /note="D->P: Increases transactivation activity."; /evidence="ECO:0000269|PubMed:19919181"; MUTAGEN 572; /note="S->A: Greatly impairs in vitro phosphorylation by CK2 and impairs cell cycle regulation activity; when associated with A-503, A-505, A-518, A-579 and A-584."; /evidence="ECO:0000269|PubMed:26711270"; MUTAGEN 579; /note="S->A: Greatly impairs in vitro phosphorylation by CK2 and impairs cell cycle regulation activity; when associated with A-503, A-505, A-518, A-572 and A-584."; /evidence="ECO:0000269|PubMed:26711270"; MUTAGEN 584; /note="S->A: Greatly impairs in vitro phosphorylation by CK2 and impairs cell cycle regulation activity; when associated with A-503, A-505, A-518, A-572 and A-579."; /evidence="ECO:0000269|PubMed:26711270"; MUTAGEN 617; /note="P->G: Complete loss of interaction with DDX39A."; /evidence="ECO:0000269|PubMed:33941617
uniprot
proteins
post_translational_modification
PTM: Phosphorylated predominantly by CK2 on two serine-containing clusters; involved in cell cycle regulation activity. {ECO:0000269|PubMed:26711270}.
uniprot
proteins
protein_family
ECD family
uniprot
proteins
pubmed
11090341
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16849563
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19640839
uniprot
proteins
pubmed
19919181
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22270930
uniprot
proteins
pubmed
22977192
uniprot
proteins
pubmed
23880345
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24656813
uniprot
proteins
pubmed
24722212
uniprot
proteins
pubmed
26711270
uniprot
proteins
pubmed
33941617
uniprot
proteins
pubmed
9928932
uniprot
proteins
sequence_length
644
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16849563, ECO:0000269|PubMed:19919181, ECO:0000269|PubMed:26711270}. Nucleus {ECO:0000269|PubMed:16849563, ECO:0000269|PubMed:19919181, ECO:0000269|PubMed:26711270, ECO:0000269|PubMed:33941617}. Note=Predominantly is located in the cytoplasm. {ECO:0000269|PubMed:16849563, ECO:0000269|PubMed:19919181, ECO:0000269|PubMed:26711270}.
uniprot
proteins