OVCA2
entrez
124641
canonical
uniprot
Q8WZ82
canonical
ensembl
ENSG00000262664
resolver
ensp
ENSP00000461388
resolver
enst
ENST00000572195
resolver
genesymbol
OVCA2
resolver
hgnc
HGNC:24203
resolver
uniprot
Q86XN3
resolver
uniprot
Q8IW87
resolver
uniprot
Q9UCX9
resolver
uniprot_entry
OVCA2_HUMAN
resolver
uniprot_sec
Q86XN3
resolver
uniprot_sec
Q8IW87
resolver
uniprot_sec
Q9UCX9
resolver
amino_acid_sequence
MAAQRPLRVLCLAGFRQSERGFREKTGALRKALRGRAELVCLSGPHPVPDPPGPEGARSDFGSCPPEEQPRGWWFSEQEADVFSALEEPAVCRGLEESLGMVAQALNRLGPFDGLLGFSQGAALAALVCALGQAGDPRFPLPRFILLVSGFCPRGIGFKESILQRPLSLPSLHVFGDTDKVIPSQESVQLASQFPGAITLTHSGGHFIPAAAPQRQAYLKFLDQFAE
uniprot
proteins
ec_number
3.1.1.1
uniprot
proteins
function
FUNCTION: Exhibits ester hydrolase activity with a strong preference for long-chain alkyl ester substrates and high selectivity against a variety of short, branched, and substituted esters. Is able to hydrolyze ester bonds within a wide range of p-nitrophenyl derivatives (C2-C14) in vitro, with a strong preference toward substrates of >8 carbons. {ECO:0000269|PubMed:32182256}.
uniprot
proteins
mass_dalton
24418
uniprot
proteins
mutagenesis
MUTAGEN 119; /note="S->A: Abolishes the hydrolase activity against long chain alkyl ester substrates."; /evidence="ECO:0000269|PubMed:32182256"; MUTAGEN 179; /note="D->A: Reduces the hydrolase activity against long chain alkyl ester substrates."; /evidence="ECO:0000269|PubMed:32182256"; MUTAGEN 206; /note="H->A: Abolishes the hydrolase activity against long chain alkyl ester substrates."; /evidence="ECO:0000269|PubMed:32182256
uniprot
proteins
post_translational_modification
PTM: Proteolytically degraded in response to RA and 4HPR treatment in a time- and dose-dependent manner in the promyelocytic leukemia cell line HL-60.
uniprot
proteins
protein_family
LovG family
uniprot
proteins
pubmed
11979432
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
32182256
uniprot
proteins
pubmed
8616839
uniprot
proteins
sequence_length
227
uniprot
proteins