NICOL1
entrez
401115
canonical
uniprot
Q5BLP8
canonical
ensembl
ENSG00000243449
resolver
ensp
ENSP00000386528
resolver
ensp
ENSP00000386807
resolver
genesymbol
NICOL1
resolver
genesymbol_syn
C4orf48
resolver
hgnc
HGNC:34437
resolver
uniprot
B6ZDN0
resolver
uniprot
B7ZBI7
resolver
uniprot
B7ZBI8
resolver
uniprot
X6RBU3
resolver
uniprot_entry
NICOL_HUMAN
resolver
uniprot_sec
B6ZDN0
resolver
uniprot_sec
B7ZBI7
resolver
uniprot_sec
B7ZBI8
resolver
uniprot_sec
X6RBU3
resolver
amino_acid_sequence
MAPPPACRSPMSPPPPPLLLLLLSLALLGARARAEPAGSAVPAQSRPCVDCHAFEFMQRALQDLRKTACSLDARTETLLLQAERRALCACWPAGH
uniprot
proteins
function
FUNCTION: mRNA-binding protein which interacts with a range of target mRNAs including SERPINE1, ACTA2, CCN2 and COL4A1 and may promote extracellular matrix production. Binds to the 3'-UTR of SERPINE1 mRNA and stabilizes the mRNA, possibly by competing for binding with SERBP1 and preventing SERBP1-mediated mRNA degradation. Also binds to the 3'-UTR of ACTA2. Testis-derived lumicrine factor that triggers epididymal differentiation and sperm maturation. {ECO:0000250|UniProtKB:Q3UR78}.
uniprot
proteins
mass_dalton
10170
uniprot
proteins
protein_family
NICOL family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15809229
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
21287218
uniprot
proteins
pubmed
38625739
uniprot
proteins
sequence_length
95
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q3UR78}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q3UR78}. Note=Detected in the perinuclear region of fibroblasts. {ECO:0000250|UniProtKB:Q3UR78}.
uniprot
proteins