P11369
uniprot
P11369
canonical
amino_acid_sequence
MPTLTTKIKGSNNYFSLISLNINGLNSPIKRHRLTDWLHKQDPTFCCLQETHLREKDRHYLRVKGWKTIFQANGLKKQAGVAILISDKIDFQPKVIKKDKEGHFILIKGKILQEELSILNIYAPNARAATFIRDTLVKLKAYIAPHTIIVGDFNTPLSSKDRSWKQKLNRDTVKLTEVMKQMDLTDIYRTFYPKTKGYTFFSAPHGTFSKIDHIIGHKTGLNRYKNIEIVPCILSDHHGLRLIFNNNINNGKPTFTWKLNNTLLNDTLVKEGIKKEIKDFLEFNENEATTYPNLWDTMKAFLRGKLIALSASKKKRETAHTSSLTTHLKALEKKEANSPKRSRRQEIIKLRGEINQVETRRTIQRINQTRSWFFEKINKIDKPLARLTKGHRDKILINKIRNEKGDITTDPEEIQNTIRSFYKRLYSTKLENLDEMDKFLDRYQVPKLNQDQVDHLNSPISPKEIEAVINSLPTKKSPGPDGFSAEFYQTFKEDLIPILHKLFHKIEVEGTLPNSFYEATITLIPKPQKDPTKIENFRPISLMNIDAKILNKILANRIQEHIKAIIHPDQVGFIPGMQGWFNIRKSINVIHYINKLKDKNHMIISLDAEKAFDKIQHPFMIKVLERSGIQGPYLNMIKAIYSKPVANIKVNGEKLEAIPLKSGTRQGCPLSPYLFNIVLEVLARAIRQQKEIKGIQIGKEEVKISLLADDMIVYISDPKNSTRELLNLINSFGEVVGYKINSNKSMAFLYTKNKQAEKEIRETTPFSIVTNNIKYLGVTLTKEVKDLYDKNFKSLKKEIKEDLRRWKDLPCSWIGRINIVKMAILPKAIYRFNAIPIKIPTQFFNELEGAICKFVWNNKKPRIAKSLLKDKRTSGGITMPDLKLYYRAIVIKTAWYWYRDRQVDQWNRIEDPEMNPHTYGHLIFDKGAKTIQWKKDSIFNNWCWHNWLLSCRRMRIDPYLSPCTKVKSKWIKELHIKPETLKLIEEKVGKSLEDMGTGEKFLNRTAMACAVRSRIDKWDLMKLQSFCKAKDTVNKTKRPPTDWERIFTYPKSDRGLISNIYKELKKVDFRKSNNPIKKWGSELNKEFSPEEYRMAEKHLKKCSTSLIIREMQIKTTLRFHLTPVRMAKIKNSGDSRCWRGCGERGTLLHCWWECRLVQPLWKSVWRFLRKLDIVLPEDPAIPLLGIYPEDAPTGKKDTCSTMFIAALFIIARSWKEPRCPSTEEWIQKMWYIYTMEYYSAIKKNEFMKFLAKWMDLEGIILSEVTHSQRNSHNMYSLISGY
uniprot
proteins
ec_number
2.7.7.49
uniprot
proteins
ec_number
3.1.21.-
uniprot
proteins
function
FUNCTION: Has reverse transcriptase activity required for target-primed reverse transcription of the LINE-1 element mRNA, a crucial step in LINE-1 retrotransposition (By similarity). Selectively binds and reversely transcribes RNA with a poly(A) tail consisting of at least 20 adenosines (By similarity). Also has endonuclease activity that allows the introduction of nicks in the chromosomal target DNA (By similarity). Cleaves DNA in AT-rich regions between a 5' stretch of purines and a 3' stretch of pyrimidines, corresponding to the sites of LINE-1 integration in the genome (By similarity). Conformational properties of the target DNA sequence rather than specific nucleotides are key determinants of the ORF2p capacity for sequence-specific DNA recognition (By similarity). Unlike related endonucleases, does not bend the DNA helix but causes compression near the cleavage site (By similarity). {ECO:0000250|UniProtKB:O00370}.
uniprot
proteins
mass_dalton
149581
uniprot
proteins
pubmed
28662698
uniprot
proteins
pubmed
3008107
uniprot
proteins
pubmed
3023821
uniprot
proteins
pubmed
7533116
uniprot
proteins
sequence_length
1281
uniprot
proteins