BLVRA
entrez
644
canonical
uniprot
P53004
canonical
ensembl
ENSG00000106605
resolver
ensp
ENSP00000265523
resolver
ensp
ENSP00000385757
resolver
ensp
ENSP00000524165
resolver
ensp
ENSP00000524167
resolver
ensp
ENSP00000599473
resolver
ensp
ENSP00000610958
resolver
enst
ENST00000265523
resolver
enst
ENST00000402924
resolver
enst
ENST00000854106
resolver
enst
ENST00000854108
resolver
enst
ENST00000929414
resolver
enst
ENST00000940899
resolver
genesymbol
BLVRA
resolver
genesymbol_syn
BLVR
resolver
genesymbol_syn
BVR
resolver
hgnc
HGNC:1062
resolver
uniprot
A0A140VJF4
resolver
uniprot
A8K747
resolver
uniprot
O95019
resolver
uniprot
Q86UX0
resolver
uniprot
Q96QL4
resolver
uniprot
Q9BRW8
resolver
uniprot_entry
A0A140VJF4_HUMAN
resolver
uniprot_entry
BIEA_HUMAN
resolver
uniprot_sec
A8K747
resolver
uniprot_sec
O95019
resolver
uniprot_sec
Q86UX0
resolver
uniprot_sec
Q96QL4
resolver
uniprot_sec
Q9BRW8
resolver
amino_acid_sequence
MNAEPERKFGVVVVGVGRAGSVRMRDLRNPHPSSAFLNLIGFVSRRELGSIDGVQQISLEDALSSQEVEVAYICSESSSHEDYIRQFLNAGKHVLVEYPMTLSLAAAQELWELAEQKGKVLHEEHVELLMEEFAFLKKEVVGKDLLKGSLLFTAGPLEEERFGFPAFSGISRLTWLVSLFGELSLVSATLEERKEDQYMKMTVCLETEKKSPLSWIEEKGPGLKRNRYLSFHFKSGSLENVPNVGVNKNIFLKDQNIFVQKLLGQFSEKELAAEKKRILHCLGLAEEIQKYCCSRK
uniprot
proteins
disease_involvement
DISEASE: Hyperbiliverdinemia (HBLVD) [MIM:614156]: A condition characterized by a green discoloration of the skin, urine, serum, and other bodily fluids. It is due to increased biliverdin resulting from inefficient conversion to bilirubin. Affected individuals appear to have symptoms only in the context of obstructive cholestasis and/or liver failure. In some cases, green jaundice can resolve after resolution of obstructive cholestasis. {ECO:0000269|PubMed:19580635}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
1.3.1.24
uniprot
proteins
function
FUNCTION: Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor (PubMed:10858451, PubMed:7929092, PubMed:8424666, PubMed:8631357). Does not reduce bilirubin IXbeta (PubMed:10858451). Uses the reactants NADH or NADPH depending on the pH; NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7) (PubMed:7929092, PubMed:8424666, PubMed:8631357). NADPH, however, is the probable reactant in biological systems (PubMed:7929092). {ECO:0000269|PubMed:10858451, ECO:0000269|PubMed:7929092, ECO:0000269|PubMed:8424666, ECO:0000269|PubMed:8631357}.
uniprot
proteins
mass_dalton
33428
uniprot
proteins
pathway_participation
PATHWAY: Porphyrin-containing compound metabolism; protoheme degradation.
uniprot
proteins
protein_family
Biliverdin reductase subfamily
uniprot
proteins
protein_family
Gfo/Idh/MocA family
uniprot
proteins
pubmed
10858451
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19580635
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
7929092
uniprot
proteins
pubmed
8424666
uniprot
proteins
pubmed
8631357
uniprot
proteins
pubmed
8950184
uniprot
proteins
sequence_length
296
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:7929092, ECO:0000269|PubMed:8424666}.
uniprot
proteins