PDE7B
entrez
27115
canonical
uniprot
Q9NP56
canonical
ensembl
ENSG00000171408
resolver
ensp
ENSP00000310661
resolver
enst
ENST00000308191
resolver
genesymbol
PDE7B
resolver
hgnc
HGNC:8792
resolver
uniprot
Q5W154
resolver
uniprot_entry
PDE7B_HUMAN
resolver
uniprot_sec
Q5W154
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by dipyridamole, IBMX and SCH 51866 (PubMed:10814504, PubMed:10872825). Insensitive to zaprinast, rolipram, and milrinone (PubMed:10814504, PubMed:10872825). {ECO:0000269|PubMed:10814504, ECO:0000269|PubMed:10872825}.
uniprot
proteins
amino_acid_sequence
MSCLMVERCGEILFENPDQNAKCVCMLGDIRLRGQTGVRAERRGSYPFIDFRLLNSTTYSGEIGTKKKVKRLLSFQRYFHASRLLRGIIPQAPLHLLDEDYLGQARHMLSKVGMWDFDIFLFDRLTNGNSLVTLLCHLFNTHGLIHHFKLDMVTLHRFLVMVQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLASFLTPLDIMLGLLAAAAHDVDHPGVNQPFLIKTNHHLANLYQNMSVLENHHWRSTIGMLRESRLLAHLPKEMTQDIEQQLGSLILATDINRQNEFLTRLKAHLHNKDLRLEDAQDRHFMLQIALKCADICNPCRIWEMSKQWSERVCEEFYRQGELEQKFELEISPLCNQQKDSIPSIQIGFMSYIVEPLFREWAHFTGNSTLSENMLGHLAHNKAQWKSLLPRQHRSRGSSGSGPDHDHAGQGTESEEQEGDSP
uniprot
proteins
ec_number
3.1.4.53
uniprot
proteins
function
FUNCTION: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:10814504, PubMed:10872825). May be involved in the control of cAMP-mediated neural activity and cAMP metabolism in the brain (PubMed:10814504). {ECO:0000269|PubMed:10814504, ECO:0000269|PubMed:10872825}.
uniprot
proteins
mass_dalton
51835
uniprot
proteins
pathway_participation
PATHWAY: Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1. {ECO:0000269|PubMed:10814504, ECO:0000269|PubMed:10872825}.
uniprot
proteins
protein_family
Cyclic nucleotide phosphodiesterase family
uniprot
proteins
protein_family
PDE7 subfamily
uniprot
proteins
pubmed
10814504
uniprot
proteins
pubmed
10872825
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19690332
uniprot
proteins
sequence_length
450
uniprot
proteins