Slc30a2
entrez
230810
canonical
uniprot
Q2HJ10
canonical
ensembl
ENSMUSG00000028836
resolver
ensp
ENSMUSP00000079875
resolver
ensp
ENSMUSP00000101498
resolver
ensp
ENSMUSP00000101500
resolver
enst
ENSMUST00000081094
resolver
enst
ENSMUST00000105872
resolver
genesymbol
Slc30a2
resolver
genesymbol_syn
Znt2
resolver
uniprot
D3Z5N0
resolver
uniprot
D3Z5N1
resolver
uniprot_entry
D3Z5N1_MOUSE
resolver
uniprot_entry
ZNT2_MOUSE
resolver
uniprot_sec
D3Z5N0
resolver
amino_acid_sequence
MQTMDKQNLLESTRGARSFLGSLWKSEASRIPPVDLPAVELAVQSNHYCHAQKDSGSHPDPEKQRARRKLYVASAICLVFMIGEIIGGYLAQSLAIMTDAAHLLTDFASMLISLFALWVSSRPATKTMNFGWHRAEILGALLSVLSIWVVTGVLVYLAVQRLISGDYEIKGDTMLITSGCAVAVNLIMGLALHQSGHGHSHGNSRDDSSQQQNPSVRAAFIHVIGDLLQSVGVLVAAYIIYFKPEYKYVDPICTFLFSILVLGTTLTILRDVILVLMEGTPKGVDFTTVKNLLLSVDGVEALHSLHIWALTVAQPVLSVHIAIAQNADAQAVLKVARDRLQGKFNFHTMTIQIEKYSEDMKNCQACQGPLE
uniprot
proteins
function
FUNCTION: [Isoform 1]: Electroneutral proton-coupled antiporter concentrating zinc ions into a variety of intracellular organelles including endosomes, zymogen granules and mitochondria. Thereby, plays a crucial role in cellular zinc homeostasis to confer upon cells protection against its potential cytotoxicity (PubMed:21289295). Regulates the zinc concentration of milk, through the transport of zinc ions into secretory vesicles of mammary cells (Probable). By concentrating zinc ions into lysosomes participates to lysosomal-mediated cell death during early mammary gland involution (By similarity). {ECO:0000250|UniProtKB:Q9BRI3, ECO:0000269|PubMed:21289295, ECO:0000305|PubMed:19496757}.; FUNCTION: [Isoform 2]: Electroneutral proton-coupled antiporter mediating the efflux of zinc ions through the plasma membrane. {ECO:0000305|PubMed:19496757}.
uniprot
proteins
mass_dalton
40639
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-295. Phosphorylation at Ser-295 prevents localization to lysosomes. Dephosphorylation of Ser-295 which triggers localization to lysosomes, accumulation of zinc into lysosomes and lysosomal-mediated cell death is induced by TNF. {ECO:0000250|UniProtKB:Q9BRI3}.
uniprot
proteins
protein_family
Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
uniprot
proteins
protein_family
SLC30A subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19496757
uniprot
proteins
pubmed
20133611
uniprot
proteins
pubmed
21289295
uniprot
proteins
sequence_length
371
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000305|PubMed:19496757}; Multi-pass membrane protein {ECO:0000255}. Zymogen granule membrane {ECO:0000269|PubMed:20133611}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000305|PubMed:19496757}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:Q9BRI3}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion inner membrane {ECO:0000269|PubMed:21289295}; Multi-pass membrane protein {ECO:0000255}. Note=Localization to lysosomes is induced by TNF. {ECO:0000250|UniProtKB:Q9BRI3}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000305|PubMed:19496757}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 70..90; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 100..120; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 137..157; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 173..193; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 220..240; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 249..269; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 304..324; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins