GRM2
entrez
2912
canonical
uniprot
Q14416
canonical
ensembl
ENSG00000164082
resolver
ensp
ENSP00000296479
resolver
ensp
ENSP00000378492
resolver
ensp
ENSP00000559687
resolver
ensp
ENSP00000559688
resolver
ensp
ENSP00000611391
resolver
enst
ENST00000296479
resolver
enst
ENST00000395052
resolver
enst
ENST00000889628
resolver
enst
ENST00000889629
resolver
enst
ENST00000941332
resolver
genesymbol
GRM2
resolver
genesymbol_syn
GPRC1B
resolver
genesymbol_syn
MGLUR2
resolver
hgnc
HGNC:4594
resolver
uniprot
B0M0K7
resolver
uniprot
H7BXL3
resolver
uniprot
Q14CU5
resolver
uniprot
Q52MC6
resolver
uniprot
Q9H3N6
resolver
uniprot_entry
GRM2_HUMAN
resolver
uniprot_entry
H7BXL3_HUMAN
resolver
uniprot_sec
B0M0K7
resolver
uniprot_sec
Q14CU5
resolver
uniprot_sec
Q52MC6
resolver
uniprot_sec
Q9H3N6
resolver
amino_acid_sequence
MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALDRINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVIGGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLAASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWEQRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYKDFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASPSAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEYIRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTAVCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVVEAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAARASSSLGQGSGSQFVPTVCNGREVVDSTTSSL
uniprot
proteins
function
FUNCTION: Dimeric G protein-coupled receptor which is activated by the excitatory neurotransmitter L-glutamate (PubMed:37286794). Plays critical roles in modulating synaptic transmission and neuronal excitability. Upon activation by glutamate, inhibits presynaptic calcium channels, reducing further glutamate release and dampening excitatory signaling (By similarity). Mechanistically, ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. {ECO:0000250|UniProtKB:Q14BI2, ECO:0000269|PubMed:18297054, ECO:0000269|PubMed:22300836, ECO:0000269|PubMed:23129762, ECO:0000269|PubMed:37286794, ECO:0000269|PubMed:7620613}.; FUNCTION: (Microbial infection) Plays an important role in influenza virus internalization. {ECO:0000269|PubMed:38849624}.; FUNCTION: (Microbial infection) Acts as a host entry factor for rabies virus that hijacks the endocytosis of GRM2 to enter cells. {ECO:0000269|PubMed:30028877}.; FUNCTION: (Microbial infection) Acts as a host entry factor for SARS-CoV-2 that hijacks the endocytosis of GRM2 to enter cells. {ECO:0000269|PubMed:34903715}.
uniprot
proteins
mass_dalton
95568
uniprot
proteins
mutagenesis
MUTAGEN 677; /note="A->S: Impairs interaction with HTR2A."; /evidence="ECO:0000269|PubMed:23129762"; MUTAGEN 681; /note="A->F: Impairs interaction with HTR2A."; /evidence="ECO:0000269|PubMed:23129762"; MUTAGEN 685; /note="A->G: Impairs interaction with HTR2A."; /evidence="ECO:0000269|PubMed:23129762
uniprot
proteins
protein_family
G protein-coupled receptor 3 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18297054
uniprot
proteins
pubmed
22300836
uniprot
proteins
pubmed
23129762
uniprot
proteins
pubmed
26313429
uniprot
proteins
pubmed
30028877
uniprot
proteins
pubmed
34903715
uniprot
proteins
pubmed
37286794
uniprot
proteins
pubmed
38849624
uniprot
proteins
pubmed
7620613
uniprot
proteins
sequence_length
872
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Synapse {ECO:0000250}. Cell projection, dendrite {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 568..590; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 605..625; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 637..655; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 680..700; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 726..747; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 761..783; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 794..819; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins