Smad4
entrez
17128
canonical
uniprot
P97471
canonical
ensembl
ENSMUSG00000024515
resolver
ensp
ENSMUSP00000025393
resolver
ensp
ENSMUSP00000110589
resolver
ensp
ENSMUSP00000197747
resolver
ensp
ENSMUSP00000197749
resolver
ensp
ENSMUSP00000197756
resolver
ensp
ENSMUSP00000197762
resolver
enst
ENSMUST00000025393
resolver
enst
ENSMUST00000114939
resolver
genesymbol
Smad4
resolver
genesymbol_syn
Dpc4
resolver
genesymbol_syn
Madh4
resolver
uniprot
E3SRG7
resolver
uniprot
E3SRG8
resolver
uniprot
Q6GTP6
resolver
uniprot
Q9CW56
resolver
uniprot_entry
E3SRG7_MOUSE
resolver
uniprot_entry
E3SRG8_MOUSE
resolver
uniprot_entry
SMAD4_MOUSE
resolver
uniprot_sec
Q6GTP6
resolver
uniprot_sec
Q9CW56
resolver
amino_acid_sequence
MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITAITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFDLKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSMLVKDEYVHDFEGQPSLPTEGHSIQTIQHPPSNRASTETYSAPALLAPAESNATSTTNFPNIPVASTSQPASILAGSHSEGLLQIASGPQPGQQQNGFTAQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPPHPGHYWPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPVVTVDGYVDPSGGDRFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGRAPGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVGGIAPAISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRALQLLDEVLHTMPIADPQPLD
uniprot
proteins
function
FUNCTION: Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in response to TGF-beta. May act as a tumor suppressor. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator (By similarity). Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (PubMed:15329343). Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (PubMed:15329343). In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. {ECO:0000250, ECO:0000269|PubMed:15329343, ECO:0000269|PubMed:24076600}.
uniprot
proteins
mass_dalton
60342
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PDPK1. {ECO:0000250}.; PTM: Monoubiquitinated on Lys-518 by E3 ubiquitin-protein ligase TRIM33. Monoubiquitination hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. Deubiquitination by USP9X restores its competence to mediate TGF-beta signaling (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Dwarfin/SMAD family
uniprot
proteins
pubmed
12370310
uniprot
proteins
pubmed
15329343
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16115198
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20147459
uniprot
proteins
pubmed
21145499
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24076600
uniprot
proteins
pubmed
9166592
uniprot
proteins
sequence_length
551
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q13485}. Nucleus {ECO:0000250|UniProtKB:Q13485}. Note=In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with R-SMAD. PDPK1 prevents its nuclear translocation. {ECO:0000250|UniProtKB:Q13485}.
uniprot
proteins