Kcnj14
entrez
276720
canonical
uniprot
O70596
canonical
ensembl
ENSRNOG00000021056
resolver
ensembl
ENSRNOG00000083583
resolver
ensembl
ENSRNOG00055006711
resolver
ensembl
ENSRNOG00060011075
resolver
ensembl
ENSRNOG00065031806
resolver
ensp
ENSRNOP00000028591
resolver
ensp
ENSRNOP00000111788
resolver
ensp
ENSRNOP00055008553
resolver
ensp
ENSRNOP00060014618
resolver
ensp
ENSRNOP00065045051
resolver
enst
ENSRNOT00000028591
resolver
enst
ENSRNOT00000162049
resolver
enst
ENSRNOT00055010969
resolver
enst
ENSRNOT00060018747
resolver
enst
ENSRNOT00065054785
resolver
genesymbol
Kcnj14
resolver
genesymbol_syn
Irk4
resolver
uniprot_entry
KCJ14_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Channel activity is regulated by variations of cytosolic pH; channels are activated by alkaline and inhibited by acidic pH values (By similarity). Inhibited by Ba(2+) and Cs(+) in a voltage-dependent manner; sensitivity to those inhibitors is lower than in other Kir channels (PubMed:9592090). {ECO:0000250|UniProtKB:Q9UNX9, ECO:0000269|PubMed:9592090}.
uniprot
proteins
amino_acid_sequence
MGLARALRRLSGALEPGNSRAGDEEEAGAGLCRNGWAPGPVAGNRRRGRFVKKDGHCNVRFVNLGGQGARYLSDLFTTCVDVRWRWMCLLFSCSFLASWLLFGLTFWLIASLHGDLAAPPPPAPCFSQVASFLAAFLFALETQTSIGYGVRSVTEECPAAVAAVVLQCIAGCVLDAFVVGAVMAKMAKPKKRNETLVFSENAVVALRDRRLCLMWRVGNLRRSHLVEAHVRAQLLQPRVTPEGEYIPLDHQDVDVGFDGGTDRIFLVSPITIVHEIDSASPLYELGRAELARADFELVVILEGMVEATAMTTQCRSSYLPGELLWGHRFEPVLFQRGSQYEVDYRHFHRTYEVPGTPVCSAKELDERAEQASHSPKSSFPGSLAAFCYENELALSCCQEEDEEEDTKEGTSAETPDRAASPQALTPTLALTLPP
uniprot
proteins
function
FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. {ECO:0000269|PubMed:9592090}.
uniprot
proteins
mass_dalton
47609
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ14 subfamily
uniprot
proteins
pubmed
9592090
uniprot
proteins
sequence_length
434
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 82..108; /note="Helical; Name=M1"; /evidence="ECO:0000250|UniProtKB:F1NHE9"; TRANSMEM 158..185; /note="Helical; Name=M2"; /evidence="ECO:0000250|UniProtKB:F1NHE9
uniprot
proteins