B4GALT5
entrez
9334
canonical
uniprot
O43286
canonical
ensembl
ENSG00000158470
resolver
ensp
ENSP00000360776
resolver
enst
ENST00000371711
resolver
genesymbol
B4GALT5
resolver
hgnc
HGNC:928
resolver
uniprot
E1P625
resolver
uniprot
Q2M394
resolver
uniprot
Q9UJQ8
resolver
uniprot
U6C5D7
resolver
uniprot_entry
B4GT5_HUMAN
resolver
uniprot_sec
E1P625
resolver
uniprot_sec
Q2M394
resolver
uniprot_sec
Q9UJQ8
resolver
uniprot_sec
U6C5D7
resolver
amino_acid_sequence
MRARRGLLRLPRRSLLAALFFFSLSSSLLYFVYVAPGIVNTYLFMMQAQGILIRDNVRTIGAQVYEQVLRSAYAKRNSSVNDSDYPLDLNHSETFLQTTTFLPEDFTYFANHTCPERLPSMKGPIDINMSEIGMDYIHELFSKDPTIKLGGHWKPSDCMPRWKVAILIPFRNRHEHLPVLFRHLLPMLQRQRLQFAFYVVEQVGTQPFNRAMLFNVGFQEAMKDLDWDCLIFHDVDHIPESDRNYYGCGQMPRHFATKLDKYMYLLPYTEFFGGVSGLTVEQFRKINGFPNAFWGWGGEDDDLWNRVQNAGYSVSRPEGDTGKYKSIPHHHRGEVQFLGRYALLRKSKERQGLDGLNNLNYFANITYDALYKNITVNLTPELAQVNEY
uniprot
proteins
ec_number
2.4.1.-
uniprot
proteins
ec_number
2.4.1.274
uniprot
proteins
function
FUNCTION: Catalyzes the synthesis of lactosylceramide (LacCer) via the transfer of galactose from UDP-galactose to glucosylceramide (GlcCer) (PubMed:24498430). LacCer is the starting point in the biosynthesis of all gangliosides (membrane-bound glycosphingolipids) which play pivotal roles in the CNS including neuronal maturation and axonal and myelin formation (By similarity). Plays a role in the glycosylation of BMPR1A and regulation of its protein stability (By similarity). Essential for extraembryonic development during early embryogenesis (By similarity). {ECO:0000250|UniProtKB:Q9JMK0, ECO:0000269|PubMed:24498430}.
uniprot
proteins
mass_dalton
45119
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation.; PATHWAY: Sphingolipid metabolism.
uniprot
proteins
protein_family
Glycosyltransferase 7 family
uniprot
proteins
pubmed
10580128
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24498430
uniprot
proteins
pubmed
29415997
uniprot
proteins
pubmed
9435216
uniprot
proteins
pubmed
9597550
uniprot
proteins
sequence_length
388
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:P15291}; Single-pass type II membrane protein. Golgi apparatus {ECO:0000250|UniProtKB:A0A1S6M251}. Note=Trans cisternae of Golgi stack. {ECO:0000250|UniProtKB:P15291}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..35; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins