Bglap
entrez
12096
canonical
uniprot
P86546
canonical
ensembl
ENSMUSG00000074483
resolver
ensp
ENSMUSP00000075425
resolver
enst
ENSMUST00000076048
resolver
genesymbol
Bglap
resolver
genesymbol_syn
Ocn
resolver
uniprot
P04641
resolver
uniprot_entry
OSTCN_MOUSE
resolver
uniprot_sec
P04641
resolver
amino_acid_sequence
MRTIFLLTLLTLAALCLSDLTDAKPSGPESDKAFMSKQEGNKVVNRLRRYLGASVPSPDPLEPTREQCELNPACDELSDQYGLKTAYKRIYGITI
uniprot
proteins
function
FUNCTION: The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein (By similarity). Acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralization (PubMed:8684484). Binds strongly to apatite and calcium upon gamma-carboxylation; this modification is essential for bone metabolism (PubMed:17693256). {ECO:0000250|UniProtKB:P02818, ECO:0000269|PubMed:17693256, ECO:0000269|PubMed:8684484}.; FUNCTION: The uncarboxylated form acts as a hormone secreted by osteoblasts, which regulates different cellular processes, such as energy metabolism, male fertility and brain development (PubMed:17693256, PubMed:20655470, PubMed:20655471, PubMed:21333348, PubMed:24074871). Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation, insulin secretion and sensitivity and energy expenditure (PubMed:17693256, PubMed:20655470, PubMed:20655471). Uncarboxylated osteocalcin hormone also promotes testosterone production in the testes: acts as a ligand for G protein-coupled receptor GPRC6A at the surface of Leydig cells, initiating a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner (PubMed:21333348). Also acts as a regulator of brain development: osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons, initiating a signaling response that prevents neuronal apoptosis in the hippocampus, favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA) (PubMed:24074871, PubMed:28851741). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development (PubMed:24074871). {ECO:0000269|PubMed:17693256, ECO:0000269|PubMed:20655470, ECO:0000269|PubMed:20655471, ECO:0000269|PubMed:21333348, ECO:0000269|PubMed:24074871, ECO:0000269|PubMed:28851741}.
uniprot
proteins
mass_dalton
10549
uniprot
proteins
post_translational_modification
PTM: Carboxylated by vitamin K-dependent GGCX to form gamma-carboxyglutamate; these residues are essential for the binding of calcium (By similarity). Carboxylated in a Ptprv/Esp-dependent process (PubMed:17693256, PubMed:20655470, PubMed:20655471). Decarboxylation promotes the hormone activity (PubMed:17693256, PubMed:20655470, PubMed:20655471, PubMed:21333348, PubMed:24074871). {ECO:0000250|UniProtKB:P02818, ECO:0000269|PubMed:17693256, ECO:0000269|PubMed:20655470, ECO:0000269|PubMed:20655471, ECO:0000269|PubMed:21333348, ECO:0000269|PubMed:24074871}.
uniprot
proteins
protein_family
Osteocalcin/matrix Gla protein family
uniprot
proteins
pubmed
17693256
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20655470
uniprot
proteins
pubmed
20655471
uniprot
proteins
pubmed
21333348
uniprot
proteins
pubmed
24028588
uniprot
proteins
pubmed
24074871
uniprot
proteins
pubmed
28851741
uniprot
proteins
pubmed
29148101
uniprot
proteins
pubmed
8288580
uniprot
proteins
pubmed
8684484
uniprot
proteins
sequence_length
95
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17693256, ECO:0000269|PubMed:20655470, ECO:0000269|PubMed:20655471, ECO:0000269|PubMed:21333348, ECO:0000269|PubMed:24074871}.
uniprot
proteins