MKRN1
entrez
23608
canonical
uniprot
Q9UHC7
canonical
ensembl
ENSG00000133606
resolver
ensp
ENSP00000255977
resolver
ensp
ENSP00000416369
resolver
ensp
ENSP00000417863
resolver
ensp
ENSP00000525525
resolver
genesymbol
MKRN1
resolver
genesymbol_syn
RNF61
resolver
hgnc
HGNC:7112
resolver
uniprot
A4D1T7
resolver
uniprot
B3KXB4
resolver
uniprot
Q256Y7
resolver
uniprot
Q59G11
resolver
uniprot
Q6GSF1
resolver
uniprot
Q9H0G0
resolver
uniprot
Q9UEZ7
resolver
uniprot
Q9UHW2
resolver
uniprot_entry
MKRN1_HUMAN
resolver
uniprot_sec
A4D1T7
resolver
uniprot_sec
B3KXB4
resolver
uniprot_sec
Q256Y7
resolver
uniprot_sec
Q59G11
resolver
uniprot_sec
Q6GSF1
resolver
uniprot_sec
Q9H0G0
resolver
uniprot_sec
Q9UEZ7
resolver
uniprot_sec
Q9UHW2
resolver
amino_acid_sequence
MAEAATPGTTATTSGAGAAAATAAAASPTPIPTVTAPSLGAGGGGGGSDGSGGGWTKQVTCRYFMHGVCKEGDNCRYSHDLSDSPYSVVCKYFQRGYCIYGDRCRYEHSKPLKQEEATATELTTKSSLAASSSLSSIVGPLVEMNTGEAESRNSNFATVGAGSEDWVNAIEFVPGQPYCGRTAPSCTEAPLQGSVTKEESEKEQTAVETKKQLCPYAAVGECRYGENCVYLHGDSCDMCGLQVLHPMDAAQRSQHIKSCIEAHEKDMELSFAVQRSKDMVCGICMEVVYEKANPSERRFGILSNCNHTYCLKCIRKWRSAKQFESKIIKSCPECRITSNFVIPSEYWVEEKEEKQKLILKYKEAMSNKACRYFDEGRGSCPFGGNCFYKHAYPDGRREEPQRQKVGTSSRYRAQRRNHFWELIEERENSNPFDNDEEEVVTFELGEMLLMLLAAGGDDELTDSEDEWDLFHDELEDFYDLDL
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription. {ECO:0000269|PubMed:16785614, ECO:0000269|PubMed:19536131}.
uniprot
proteins
mass_dalton
53349
uniprot
proteins
mutagenesis
MUTAGEN 307; /note="H->E: Loss of E3 ligase activity, but no effect on transcription regulation."; /evidence="ECO:0000269|PubMed:15805468
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:19536131}.
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated; which leads to proteasomal degradation. {ECO:0000269|PubMed:15805468}.
uniprot
proteins
pubmed
10843807
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15805468
uniprot
proteins
pubmed
16785614
uniprot
proteins
pubmed
19536131
uniprot
proteins
pubmed
19604354
uniprot
proteins
sequence_length
482
uniprot
proteins