Q8R4Y4
uniprot
Q8R4Y4
canonical
amino_acid_sequence
MAEPRTLLLLCVLVLCLSDSSFIRGQTVRSKRCDIHTKFVTHTPCTACAAIRRQLCPWGWSRNFPEKILLDCRYELQLRGAAISLSGCSQECWKDVVQKACCPGYWGSQCFECPGGPATPCSGHGTCLDGIEGNGTCVCQGNFSGSVCQECRDPNRFGPDCQSVCNCVHGVCSHGPRGDGSCRCFAGYTGPHCDQELPVCQSLKCPQNSQCSAEAPTCKCLPGYTQQDNVCLAPDPCQPSACSPLARCSVTPQGQAQCQCPENYHGDGKVCLPRDPCLTNFGGCPSNSTFCLYRGPGKATCMCRPGMTSINNNASEGCHVSCKPHSCDRSATCQVTPDRKTSCVCKNDEVGDGHACYGHLLHEVRRANQNGLVFLRLRAAIAMLEQGCQEILTTSGPFTVLVPSMFSVSSVSSNMNATLAQQLCRQHVIAGEHMLENAGPPSTRRWWTLAGQEVTITFKNMRYAYKYEDQPQQFSIHKANYIAANGVFHTVTALRWQLPPPLPGDSKKTVGQILASTEVFTRFETILENCGLPSILDGPGPFTVFAPSNEAVDSLRDGRLIYLFTAGLSKLQELVRYHIYNHGQLTVEKLISKGRVLTMANQVLTVNISEGGRILLGPGGIPVRRVDVPAANGVIHMLEGILLPPTILPILPKHCDEEQHQTVLGSCVDCQALNTSVCPPNSVKMDIFPKECVYIHDPNGLNVLKKGCADYCNQTITKRGCCKGFFGPDCTQCPGGFSNPCYGKGNCSDGVRGNGACLCFPDYKGIACHICSDPKKHGEQCQEDCGCVHGLCDNRPGSGGVCQQGTCAPGFQGRFCNESMGNCGSTGLAQPCHSDAHCVIQEGVARCVCHDGFEGNGFSCKRSNPCSRPDRGGCSENAECVPGDLGTHHCICHKGWSGDGRICVAIDECGLDTRGGCHADALCSYVGPGQSRCTCKLGFAGNGYECSPIDPCRVGNGGCHGLATCKAVGGGQRVCTCPPHFGGDGFSCYGDIIQELEANAHFSAFSQWFKNSSITLPADSRVTALVPSESAIRRLSLEDQAFWLQPKMLPELARAHFLQGAFSEEELARLNGQQVATLSATTRWQIHNISGKVWVQNATVDVPDLLATNGILHIVSQVLLPPRGDMQTGPGLLQQLDSVPAFRLFGEQLKHHKLVAQIEAAKAYTIFVPTNHSLETQGNNSVLGIDTVRHHVILGEALSVEVLRKGGHRNSLLGPAHWLVFYNHSGQPEVNHMPLEGPLLEAPGSSLFGLSGILAVGSSRCLHSHAEALREKCINCTRKFRCTQGFQLQDTPRKSCVYRSGLSFSRGCSYTCAKKIQVPDCCPGFFGTLCEPCPGGLGGVCSGHGQCQDRFLGNGECRCQEGFHGTACEMCELGRYGPTCSGVCDCDHGLCQEGLRGNGSCVCHAGWQGLRCDQKITDHQCPKKCDPNANCIQDSAGIPACVCAAGYSGNGSYCSEVDPCASGHGGCSPYANCTKVAPGQRTCTCQDGYTGDGELCQEINSCLVHNGGCHVHAECIPTGPQQVSCSCREGYSGDGIQTCKLLDPCSQNNGGCSPYAVCKSTGDGQRTCSCDATHTVGDGITCHGRVGLELLRNKYASFFSLHLLEYKELKGDGPFTVFVPHADLISNMSQDELARIRAHRQLVFRYHVVGCRKLWSQEMLDQGYITTLSGHTLRVSEREGSIYLNDFARVVSSDLEVVNGVLHFIDHVLLPPDVLHWESGAIPIPQRNVTAAAESFGYKIFSRLLTVAGLLPMLQDASHRPFTMLWPTDSALQALPPDRKNWLFHEDHRDKLAAILRGHMIRNIEALASDLPNLGQLRTMHGNTISFSCGLTRPGELIVGEDEAHIVQRHLTFEGGLAYGIDQLLEPPDLGARCDRFEPQPLQMKTCSICGLEPPCPRGSREQGSPETCWRHYSKFWTTPLHSISMRGAYWIPSSFWNRNHMSRGCHRNCVTTVWKPSCCPGHYGINCHACPGGPRSPCSDHGVCLDGIRGSGQCNCHPGFAGTACELCAPGAFGPQCQACRCTQHGRCDEGLGGSGSCFCDEGWTGARCEVQLELQPVCTPPCAPQAVCRLGNSCECSLGYEGDGRVCTVADLCQKGHGGCSKHANCSQVGTVVTCTCLPDYEGDGWSCRARDPCLDGHRGGCSEHADCLNTGPNTRRCECHVGYVGDGLQCLEELEPPVDRCLGGSSPCHTDALCTDLHFQEKQAGVFHIQATSGPYGLTFSEAKEACEGQGAVLASLPQLSAAQQLGFHVCFVGWLANGSAAHPVVTPAADCGNNRVGVVSLGVRKNLSELWDAYCYRVQDVACQCRAGFVGDGISTCNGKLLDVLAATANFSTFYGMLLGYANATQRGLEFMDFLEDELTYKTLFVPVNKGFVDNMTLSGPDLELHASNATFLSINASRGTLLPAHSGLSLFISDTGPDNTSLVPLAPGAVVVSHVIVWDIMAFNGIIHALASPLLMPPQTRAVLGSEPPPVALSLGVVVTSGTLLGLVAGALYLRARGKPPGFSFSAFQAEDNADDDFSPWQEGTSPTLVSVPNPVFGSSDIFCEPFDDSVLEEDFPDTQRVLKVK
uniprot
proteins
function
FUNCTION: Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
276257
uniprot
proteins
pubmed
11829752
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
2571
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 2476..2496; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins