ANO7
entrez
50636
canonical
uniprot
Q6IWH7
canonical
ensembl
ENSG00000146205
resolver
ensp
ENSP00000383985
resolver
ensp
ENSP00000385418
resolver
ensp
ENSP00000501393
resolver
ensp
ENSP00000550399
resolver
enst
ENST00000402530
resolver
enst
ENST00000674324
resolver
genesymbol
ANO7
resolver
genesymbol_syn
NGEP
resolver
genesymbol_syn
PCANAP5
resolver
genesymbol_syn
TMEM16G
resolver
hgnc
HGNC:31677
resolver
uniprot
A0A6I8PRE6
resolver
uniprot
A0A6Q8JT31
resolver
uniprot
Q6IWH6
resolver
uniprot_entry
A0A6I8PRE6_HUMAN
resolver
uniprot_entry
A0A6Q8JT31_HUMAN
resolver
uniprot_entry
ANO7_HUMAN
resolver
uniprot_sec
Q6IWH6
resolver
amino_acid_sequence
MRMAATAWAGLQGPPLPTLCPAVRTGLYCRDQAHAERWAMTSETSSGSHCARSRMLRRRAQEEDSTVLIDVSPPEAEKRGSYGSTAHASEPGGQQAAACRAGSPAKPRIADFVLVWEEDLKLDRQQDSAARDRTDMHRTWRETFLDNLRAAGLCVDQQDVQDGNTTVHYALLSASWAVLCYYAEDLRLKLPLQELPNQASNWSAGLLAWLGIPNVLLEVVPDVPPEYYSCRFRVNKLPRFLGSDNQDTFFTSTKRHQILFEILAKTPYGHEKKNLLGIHQLLAEGVLSAAFPLHDGPFKTPPEGPQAPRLNQRQVLFQHWARWGKWNKYQPLDHVRRYFGEKVALYFAWLGFYTGWLLPAAVVGTLVFLVGCFLVFSDIPTQELCGSKDSFEMCPLCLDCPFWLLSSACALAQAGRLFDHGGTVFFSLFMALWAVLLLEYWKRKSATLAYRWDCSDYEDTEERPRPQFAASAPMTAPNPITGEDEPYFPERSRARRMLAGSVVIVVMVAVVVMCLVSIILYRAIMAIVVSRSGNTLLAAWASRIASLTGSVVNLVFILILSKIYVSLAHVLTRWEMHRTQTKFEDAFTLKVFIFQFVNFYSSPVYIAFFKGRFVGYPGNYHTLFGVRNEECAAGGCLIELAQELLVIMVGKQVINNMQEVLIPKLKGWWQKFRLRSKKRKAGASAGASQGPWEDDYELVPCEGLFDEYLEMVLQFGFVTIFVAACPLAPLFALLNNWVEIRLDARKFVCEYRRPVAERAQDIGIWFHILAGLTHLAVISNAFLLAFSSDFLPRAYYRWTRAHDLRGFLNFTLARAPSSFAAAHNRTCRYRAFRDDDGHYSQTYWNLLAIRLAFVIVFEHVVFSVGRLLDLLVPDIPESVEIKVKREYYLAKQALAENEVLFGTNGTKDEQPEGSELSSHWTPFTVPKASQLQQ
uniprot
proteins
function
FUNCTION: Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (By similarity). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:22075693). May play a role in cell-cell interactions (PubMed:17308099). {ECO:0000250|UniProtKB:Q14AT5, ECO:0000269|PubMed:17308099, ECO:0000269|PubMed:22075693}.
uniprot
proteins
mass_dalton
105532
uniprot
proteins
protein_family
Anoctamin family
uniprot
proteins
pubmed
10613842
uniprot
proteins
pubmed
14981236
uniprot
proteins
pubmed
15375614
uniprot
proteins
pubmed
15761874
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17308099
uniprot
proteins
pubmed
18676855
uniprot
proteins
pubmed
20056604
uniprot
proteins
pubmed
21607626
uniprot
proteins
pubmed
21642943
uniprot
proteins
pubmed
21984732
uniprot
proteins
pubmed
22075693
uniprot
proteins
pubmed
22302790
uniprot
proteins
pubmed
22946059
uniprot
proteins
sequence_length
933
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:14981236, ECO:0000269|PubMed:17308099, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22946059}; Multi-pass membrane protein {ECO:0000255}. Cell junction {ECO:0000269|PubMed:17308099}. Endoplasmic reticulum {ECO:0000269|PubMed:22075693}. Note=Concentrates at sites of cell-cell contact (PubMed:17308099). Shows an intracellular localization according to PubMed:22075693 and PubMed:20056604. {ECO:0000269|PubMed:17308099, ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22075693}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytosol {ECO:0000269|PubMed:14981236}.
uniprot
proteins
transmembrane_region
TRANSMEM 356..376; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 421..441; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 500..520; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 551..571; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 589..609; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 715..735; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 764..784; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 844..864; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins