CXXC5
entrez
51523
canonical
uniprot
Q7LFL8
canonical
ensembl
ENSG00000171604
resolver
ensp
ENSP00000302543
resolver
ensp
ENSP00000427379
resolver
ensp
ENSP00000567283
resolver
ensp
ENSP00000567285
resolver
ensp
ENSP00000567290
resolver
ensp
ENSP00000607665
resolver
ensp
ENSP00000607674
resolver
ensp
ENSP00000634302
resolver
genesymbol
CXXC5
resolver
hgnc
HGNC:26943
resolver
uniprot
B3KND0
resolver
uniprot
C8CBA8
resolver
uniprot
Q8TB79
resolver
uniprot
Q9NV51
resolver
uniprot
Q9P0S8
resolver
uniprot_entry
CXXC5_HUMAN
resolver
uniprot_sec
B3KND0
resolver
uniprot_sec
C8CBA8
resolver
uniprot_sec
Q8TB79
resolver
uniprot_sec
Q9NV51
resolver
uniprot_sec
Q9P0S8
resolver
amino_acid_sequence
MSSLGGGSQDAGGSSSSSTNGSGGSGSSGPKAGAADKSAVVAAAAPASVADDTPPPERRNKSGIISEPLNKSLRRSRPLSHYSSFGSSGGSGGGSMMGGESADKATAAAAAASLLANGHDLAAAMAVDKSNPTSKHKSGAVASLLSKAERATELAAEGQLTLQQFAQSTEMLKRVVQEHLPLMSEAGAGLPDMEAVAGAEALNGQSDFPYLGAFPINPGLFIMTPAGVFLAESALHMAGLAEYPMQGELASAISSGKKKRKRCGMCAPCRRRINCEQCSSCRNRKTGHQICKFRKCEELKKKPSAALEKVMLPTGAAFRWFQ
uniprot
proteins
function
FUNCTION: May indirectly participate in activation of the NF-kappa-B and MAPK pathways. Acts as a mediator of BMP4-mediated modulation of canonical Wnt signaling activity in neural stem cells (By similarity). Required for DNA damage-induced ATM phosphorylation, p53 activation and cell cycle arrest. Involved in myelopoiesis. Transcription factor. Binds to the oxygen responsive element of COX4I2 and represses its transcription under hypoxia conditions (4% oxygen), as well as normoxia conditions (20% oxygen) (PubMed:23303788). May repress COX4I2 transactivation induced by CHCHD2 and RBPJ (PubMed:23303788). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034). {ECO:0000250|UniProtKB:Q5XIQ3, ECO:0000269|PubMed:19182210, ECO:0000269|PubMed:19557330, ECO:0000269|PubMed:23303788, ECO:0000269|PubMed:29276034}.
uniprot
proteins
mass_dalton
32977
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
12761501
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19182210
uniprot
proteins
pubmed
19557330
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23303788
uniprot
proteins
pubmed
29276034
uniprot
proteins
sequence_length
322
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19182210, ECO:0000269|PubMed:19557330}. Cytoplasm {ECO:0000250|UniProtKB:Q5XIQ3}. Note=Colocalizes with DVL1 in large bodies localized just outside the nuclear membrane. {ECO:0000250|UniProtKB:Q5XIQ3}.
uniprot
proteins