Sil1
entrez
81500
canonical
uniprot
Q9EPK6
canonical
ensembl
ENSMUSG00000024357
resolver
ensp
ENSMUSP00000025215
resolver
ensp
ENSMUSP00000314473
resolver
ensp
ENSMUSP00000314476
resolver
ensp
ENSMUSP00000314479
resolver
ensp
ENSMUSP00000314480
resolver
ensp
ENSMUSP00000314493
resolver
enst
ENSMUST00000025215
resolver
genesymbol
Sil1
resolver
uniprot
Q91V34
resolver
uniprot_entry
SIL1_MOUSE
resolver
uniprot_sec
Q91V34
resolver
amino_acid_sequence
MAPQHLPSTRMASPGMLLGLLLTSCLTLCLSCQNSNNFALTNPEKSIHQESDTKETREEEELDTEILEVFHPTQEWQTLQPGQAVPAGSHVRMNLQTGVNEVKLQQEDKFQNNLKGFKRGRRLDINANTYTSQDLKSALAKFKEGTEMENSKDELARQATVKQLFRPIEELKKEFDELNVVLETDMQIMVRLINKFNSSSSSLEEKVAALFDLEYYVHQMDNAQDLLSFGGLQVVINGLNSTEPLVKEYAAFVLGAAFSSNPKVQVEAIEGGALQKLLVILATNQPLPAKKKVLFALCSLLRHFPYAQQQFLKLGGLQVLRSLVQEKSAKVLAVRVVTLLYDLVTEKMFAEEEAELTQDSSPEKLQQYRQVQLLPGLQEQGWCEITAQLLALPEHDAREKVLQTLGALLTTCRDRYRQDLQLSRTLGRLQAEYQALASLELQEGEDDGYFRELLASINSLMKELR
uniprot
proteins
function
FUNCTION: Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone HSPA5. {ECO:0000250|UniProtKB:Q9H173}.
uniprot
proteins
mass_dalton
52430
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q9H173}.; PTM: Ubiquitinated by the CRL2(FEM1A) and CRL2(FEM1C) complexes, which recognize the -Lys-Xaa-Xaa-Arg C-degron at the C-terminus, leading to its degradation. {ECO:0000250|UniProtKB:Q9H173}.
uniprot
proteins
protein_family
SIL1 family
uniprot
proteins
pubmed
11101517
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16116427
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16282977
uniprot
proteins
pubmed
16282978
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
465
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:16116427}.
uniprot
proteins