Kctd10
entrez
494521
canonical
uniprot
Q7TPL3
canonical
ensembl
ENSRNOG00000047896
resolver
ensp
ENSRNOP00000065635
resolver
ensp
ENSRNOP00000086565
resolver
enst
ENSRNOT00000073019
resolver
enst
ENSRNOT00000103729
resolver
genesymbol
Kctd10
resolver
uniprot
A0A8I6GF35
resolver
uniprot
A0A8L2QWU8
resolver
uniprot_entry
A0A8I6GF35_RAT
resolver
uniprot_entry
BACD3_RAT
resolver
uniprot_sec
A0A8L2QWU8
resolver
amino_acid_sequence
MEEMSGESVVTSAVPAAATRTTSFKGASPSSKYVKLNVGGALYYTTMQTLTKQDTMLKAMFSGRMEVLTDSEGWILIDRCGKHFGTILNYLRDGAVPLPESRREIEELLAEAKYYLVQGLLEECQAALQNKDTYEPFCKVPVITSSKEEQRLIATSDKPAVKLLYNRSNNKYSYTSNSDDNMLKNIELFDKLSLRFNGRVLFIKDVIGDEICCWSFYGQGRKIAEVCCTSIVYATEKKQTKVEFPEARIYEETLNILLYEAQDGRGPDNALLEATGGAAGRSHHLDEDEERERERIERVRRIHIKRPDDRAHLHQ
uniprot
proteins
function
FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates the ubiquitination of multiple substrates, leading to either their proteasomal or lysosomal degradation, or modulating their activity through non-degradative ubiquitination. Controls endothelial barrier function by mediating 'Lys-63'-linked polyubiquitination of RHOB, promoting its lysosomal degradation. Mediates polyubiquitination of CEP97, targeting it for proteasomal degradation. CEP97 degradation upon serum starvation is essential for primary cilium formation by enabling removal of the CEP97-CP110 complex from mother centrioles. Acts as a positive regulator of ferroptosis by destabilizing SLC7A11. Decreased SLC7A11 levels reduce cystine uptake and glutathione (GSH) biosynthesis, thereby promoting iron-dependent lipid peroxidation and ferroptotic cell death. In the innate immune response, mediates 'Lys-27'-linked polyubiquitination of TICAM1/TRIF at Lys-523 upon stimulation with LPS. This ubiquitination is essential for recruitment of TICAM1 to TLR3/4, thereby promoting TLR3/4-mediated immune signaling (By similarity). Negatively regulates KCTD13 stability through the ubiquitin/proteasome degradation pathway within the developing brain to control neuronal progenitor cell proliferation and differentiation (By similarity). Acts as a sensor for co-directional transcription-replication conflicts, where it helps coordinate the interaction between the replication machinery and RNA polymerase to allow DNA replication to continue through actively transcribed regions. Promotes recruitment of ubiquitin ligase complexes that remove stalled transcription factors, thereby maintaining genome stability by resolving these conflicts. Ubiquitinates TCEA2 to remodel the RNAP complex (By similarity). {ECO:0000250|UniProtKB:Q922M3, ECO:0000250|UniProtKB:Q9H3F6}.
uniprot
proteins
mass_dalton
35745
uniprot
proteins
mutagenesis
MUTAGEN 242..244; /note="VEF->AEA: Loss of PCNA binding."; /evidence="ECO:0000269|PubMed:15982757
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9H3F6}.
uniprot
proteins
protein_family
BACURD family
uniprot
proteins
pubmed
15982757
uniprot
proteins
sequence_length
315
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H3F6}.
uniprot
proteins