Cyp17a1
entrez
13074
canonical
uniprot
P27786
canonical
ensembl
ENSMUSG00000003555
resolver
ensp
ENSMUSP00000026012
resolver
enst
ENSMUST00000026012
resolver
genesymbol
Cyp17a1
resolver
genesymbol_syn
Cyp17
resolver
uniprot
Q3UYU1
resolver
uniprot
Q53YJ1
resolver
uniprot_entry
CP17A_MOUSE
resolver
uniprot_entry
Q3UYU1_MOUSE
resolver
uniprot_entry
Q53YJ1_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Both 17alpha-hydroxylation and 17,20 lyase activities are significantly stimulated by the presence of cytochrome b5. {ECO:0000269|PubMed:36640554}.
uniprot
proteins
amino_acid_sequence
MWELVGLLLLILAYFFWPKSKTPNAKFPRSLPFLPLVGSLPFLPRRGHMHANFFKLQEKYGPIYSLRLGTTTAVIVGHYQLAREVLVKKGKEFSGRPQMVTLGLLSDQGKGVAFADSSSSWQLHRKLVFSTFSLFRDDQKLEKMICQEANSLCDLILTYDGESRDLSTLIFKSVINIICTICFNISFENKDPILTTIQTFTEGIVDVLGHSDLVDIFPWLKIFPNKNLEMIKEHTKIREKTLVEMFEKCKEKFNSESLSSLTDILIQAKMNAENNNTGEGQDPSVFSDKHILVTVGDIFGAGIETTSSVLNWILAFLVHNPEVKRKIQKEIDQYVGFSRTPSFNDRTHLLMLEATIREVLRIRPVAPLLIPHKANIDSSIGEFAIPKDTHVIINLWALHHDKNEWDQPDRFMPERFLDPTGSHLITPTPSYLPFGAGPRSCIGEALARQELFIFMALLLQRFDFDVSDDKQLPCLVGDPKVVFLIDPFKVKITVRQAWKDAQVEVST
uniprot
proteins
ec_number
1.14.14.19
uniprot
proteins
ec_number
1.14.14.32
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione (PubMed:36640554). Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (By similarity). {ECO:0000250|UniProtKB:P05093, ECO:0000269|PubMed:36640554}.
uniprot
proteins
mass_dalton
57638
uniprot
proteins
mutagenesis
MUTAGEN 346; /note="R->H: 49% and 41% of wild-type 17alpha-hydroxylase activity with progesterone and pregnenolone respectively. 36% and 27% of wild type 17,20-lyase activity with 17alpha-hydroxyprogesterone and 17alpha-hydroxypregnenolone respectively."; /evidence="ECO:0000269|PubMed:36640554"; MUTAGEN 357; /note="R->Q: 68% and 45% of wild-type 17alpha-hydroxylase activity with progesterone and pregnenolone respectively. 64% of wild type 17,20-lyase activity with 17alpha-hydroxyprogesterone."; /evidence="ECO:0000269|PubMed:36640554
uniprot
proteins
pathway_participation
PATHWAY: Steroid hormone biosynthesis. {ECO:0000250|UniProtKB:P05093}.; PATHWAY: Steroid biosynthesis; glucocorticoid biosynthesis. {ECO:0000250|UniProtKB:P05093}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
1840559
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
36640554
uniprot
proteins
sequence_length
507
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P05093}. Microsome membrane {ECO:0000250|UniProtKB:P05093}.
uniprot
proteins