Rpl13a
entrez
22121
canonical
uniprot
P19253
canonical
ensembl
ENSMUSG00000074129
resolver
ensp
ENSMUSP00000115722
resolver
enst
ENSMUST00000150350
resolver
genesymbol
Rpl13a
resolver
genesymbol_syn
P198
resolver
genesymbol_syn
Tstap198-7
resolver
uniprot
Q5M9M0
resolver
uniprot_entry
Q5M9M0_MOUSE
resolver
uniprot_entry
RL13A_MOUSE
resolver
amino_acid_sequence
MAEGQVLVLDGRGHLLGRLAAIVAKQVLLGRKVVVVRCEGINISGNFYRNKLKYLAFLRKRMNTNPSRGPYHFRAPSRIFWRTVRGMLPHKTKRGQAALERLKVLDGIPPPYDKKKRMVVPAALKVVRLKPTRKFAYLGRLAHEVGWKYQAVTATLEEKRKEKAKMHYRKKKQILRLRKQAEKNVEKKICKFTEVLKTNGLLV
uniprot
proteins
function
FUNCTION: Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions (PubMed:36517592). Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes (PubMed:23071094). Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation (By similarity). In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex (By similarity). Involved in methylation of rRNA (By similarity). {ECO:0000250|UniProtKB:P40429, ECO:0000269|PubMed:23071094, ECO:0000269|PubMed:36517592}.
uniprot
proteins
mass_dalton
23464
uniprot
proteins
mutagenesis
MUTAGEN 77; /note="S->A: Loss of interferon-gamma induced phosphorylation."; /evidence="ECO:0000269|PubMed:23071094
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-77 upon interferon-gamma treatment in macrophages involves a DAPK1-DAPK3 kinase cascade and is causing release from the ribosome, association with the GAIT complex and subsequent involvement in transcript-selective translation inhibition. {ECO:0000269|PubMed:23071094}.; PTM: Citrullinated by PADI4. {ECO:0000269|PubMed:24463520}.
uniprot
proteins
protein_family
Universal ribosomal protein uL13 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1694221
uniprot
proteins
pubmed
23071094
uniprot
proteins
pubmed
24463520
uniprot
proteins
pubmed
36517592
uniprot
proteins
pubmed
8188249
uniprot
proteins
sequence_length
203
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:36517592}.
uniprot
proteins