Q9R144
uniprot
Q9R144
canonical
amino_acid_sequence
MEAPGEGPCSESQVIPVLEEDPVDYGCEMQLLQDGAQLQLQLQPEEFVAIADYTATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHLGKQLEEYDPEDTWQDEEYFDSYGTLKLHLEMLADQPRTTKYHSVILQNKESLKDKVILDVGCGTGIISLFCAHHARPKAVYAVEASDMAQHTSQLVLQNGFADTITVFQQKVEDVVLPEKVDVLVSEWMGTCLLFEFMIESILYARDTWLKGDGIIWPTTAALHLVPCSAEKDYHSKVLFWDNAYEFNLSALKSLAIKEFFSRPKSNHILKPEDCLSEPCTILQLDMRTVQVPDLETMRGELRFDIQKAGTLHGFTAWFSVYFQSLEEGQPQQVVSTGPLHPTTHWKQTLFMMDDPVPVHTGDVVHGFCCVTKKSGMEKAHVCLSELGCHVRTRSHVSTELETGSFRSGGDS
uniprot
proteins
ec_number
2.1.1.319
uniprot
proteins
function
FUNCTION: Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4 (PubMed:20798359). May inhibit NF-kappa-B transcription, and promote apoptosis (PubMed:16648481). Represses E2F1 transcriptional activity (in a RB1-dependent manner) (PubMed:16616919). Has a negative regulation effect on G1 to S transition of mitotic cell cycle (PubMed:16616919). Involved in growth regulation (PubMed:20708585). Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation (By similarity) Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation (By similarity). Enhances PGR, PPARG, RARA-mediated transactivation (By similarity). Involved in PRMT2IP-mediated inhibition of the microglial inflammatory responses through suppression of NF-kappa-B signaling, thereby reducing the production of pro-inflammatory cytokines (By similarity). {ECO:0000250|UniProtKB:P55345, ECO:0000269|PubMed:16616919, ECO:0000269|PubMed:16648481, ECO:0000269|PubMed:20708585, ECO:0000269|PubMed:20798359}.
uniprot
proteins
mass_dalton
50476
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
Protein arginine N-methyltransferase family
uniprot
proteins
pubmed
16616919
uniprot
proteins
pubmed
16648481
uniprot
proteins
pubmed
20708585
uniprot
proteins
pubmed
20798359
uniprot
proteins
sequence_length
448
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P55345}. Nucleus {ECO:0000250|UniProtKB:P55345}. Note=Translocates from the cytoplasm to the nucleus, after hormone exposure. {ECO:0000250|UniProtKB:P55345}.
uniprot
proteins