Nme3
entrez
79059
canonical
uniprot
Q9WV85
canonical
ensembl
ENSMUSG00000073435
resolver
ensp
ENSMUSP00000024978
resolver
enst
ENSMUST00000024978
resolver
genesymbol
Nme3
resolver
uniprot
Q9D931
resolver
uniprot
Q9EPA2
resolver
uniprot_entry
NDKC_MOUSE
resolver
uniprot_sec
Q9D931
resolver
uniprot_sec
Q9EPA2
resolver
amino_acid_sequence
MICLVLTIFANLFPSAYSGVNERTFLAVKPDGVQRRLVGEIVRRFERKGFKLVALKLVQASEELLREHYVELREKPFYSRLVKYMSSGPVVAMVWQGLDVVHASRALIGATDPGDAMPGTIRGDFCMEVGKNVIHGSDSVESAHREIALWFREAELLCWEDSAGHWLYE
uniprot
proteins
ec_number
2.7.4.6
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside diphosphate via a ping-pong mechanism involving a phosphohistidine intermediate, therefore contributing to the nucleoside triphosphate homeostasis (PubMed:22438820). In vitro, can also use other phosphate donors such as UTP and GTP. Independently of its nucleoside diphosphate kinase activity, involved in mitochondrial membrane tethering, a prerequisite for fusion through direct membrane-binding and hexamerization. Involved in DNA repair of both single- and double-stranded breaks by associating with the ribonucleotide reductase (RNR) complex via interaction with the histone acetyltransferase KAT5, facilitating recruitment to DNA damage sites independently of its kinase activity (By similarity). Inhibits granulocyte differentiation (By similarity). May be required for ciliary function during renal development (By similarity). {ECO:0000250|UniProtKB:Q13232, ECO:0000250|UniProtKB:Q9PTF3, ECO:0000269|PubMed:22438820}.
uniprot
proteins
mass_dalton
19099
uniprot
proteins
mutagenesis
MUTAGEN 89; /note="P->S: Strongly reduced nucleoside diphosphate kinase activity."; /evidence="ECO:0000269|PubMed:22438820
uniprot
proteins
post_translational_modification
PTM: Autophosphorylation is Mg(2+)-dependent. {ECO:0000250|UniProtKB:Q13232}.
uniprot
proteins
protein_family
NDK family
uniprot
proteins
pubmed
12383506
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22438820
uniprot
proteins
pubmed
30111592
uniprot
proteins
sequence_length
169
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q13232}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q13232}. Cytoplasm {ECO:0000250|UniProtKB:Q13232}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:30111592}.
uniprot
proteins