FPGS
entrez
2356
canonical
uniprot
Q05932
canonical
ensembl
ENSG00000136877
resolver
ensp
ENSP00000362322
resolver
ensp
ENSP00000362344
resolver
ensp
ENSP00000377309
resolver
ensp
ENSP00000787197
resolver
genesymbol
FPGS
resolver
hgnc
HGNC:3824
resolver
uniprot
B3KPW4
resolver
uniprot
B7Z2Z3
resolver
uniprot
F5H0K6
resolver
uniprot
Q5JU19
resolver
uniprot
Q5JU22
resolver
uniprot
Q6P2P6
resolver
uniprot_entry
FOLC_HUMAN
resolver
uniprot_sec
B3KPW4
resolver
uniprot_sec
B7Z2Z3
resolver
uniprot_sec
F5H0K6
resolver
uniprot_sec
Q5JU19
resolver
uniprot_sec
Q5JU22
resolver
uniprot_sec
Q6P2P6
resolver
activity_regulation
ACTIVITY REGULATION: Activated by 10 mM sodium bicarbonate. {ECO:0000269|PubMed:8662720}.
uniprot
proteins
amino_acid_sequence
MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAGYLEQVKRQRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVTGTKGKGSTCAFTECILRSYGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHRLEETKDGSCVSMPPYFRFLTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIAWQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCPMLEALEEGGPPLTLGLEGEHQRSNAALALQLAHCWLQRQDRHGAGEPKASRPGLLWQLPLAPVFQPTSHMRLGLRNTEWPGRTQVLRRGPLTWYLDGAHTASSAQACVRWFRQALQGRERPSGGPEVRVLLFNATGDRDPAALLKLLQPCQFDYAVFCPNLTEVSSTGNADQQNFTVTLDQVLLRCLEHQQHWNHLDEEQASPDLWSAPSPEPGGSASLLLAPHPPHTCSASSLVFSCISHALQWISQGRDPIFQPPSPPKGLLTHPVAHSGASILREAAAIHVLVTGSLHLVGGVLKLLEPALSQ
uniprot
proteins
ec_number
6.3.2.17
uniprot
proteins
function
FUNCTION: Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates. {ECO:0000269|PubMed:8408018, ECO:0000269|PubMed:8408019, ECO:0000269|PubMed:8408021, ECO:0000269|PubMed:8662720}.
uniprot
proteins
mass_dalton
64609
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.
uniprot
proteins
protein_family
Folylpolyglutamate synthase family
uniprot
proteins
pubmed
1409616
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16169100
uniprot
proteins
pubmed
17875718
uniprot
proteins
pubmed
18672898
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
7721888
uniprot
proteins
pubmed
8408018
uniprot
proteins
pubmed
8408019
uniprot
proteins
pubmed
8408020
uniprot
proteins
pubmed
8408021
uniprot
proteins
pubmed
8521387
uniprot
proteins
pubmed
8662720
uniprot
proteins
sequence_length
587
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion inner membrane {ECO:0000269|PubMed:16169100}. Mitochondrion matrix {ECO:0000269|PubMed:16169100, ECO:0000269|PubMed:8408020, ECO:0000269|PubMed:8662720}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:8662720}.
uniprot
proteins