Hexim1
entrez
498008
canonical
uniprot
Q5M9G1
canonical
ensembl
ENSRNOG00000003203
resolver
ensembl
ENSRNOG00055031619
resolver
ensembl
ENSRNOG00060015375
resolver
ensembl
ENSRNOG00065033253
resolver
ensp
ENSRNOP00000004272
resolver
ensp
ENSRNOP00000098947
resolver
ensp
ENSRNOP00000100278
resolver
ensp
ENSRNOP00000102925
resolver
ensp
ENSRNOP00000111807
resolver
ensp
ENSRNOP00055045257
resolver
ensp
ENSRNOP00060021053
resolver
ensp
ENSRNOP00065047053
resolver
enst
ENSRNOT00000004272
resolver
enst
ENSRNOT00000122853
resolver
enst
ENSRNOT00000128032
resolver
enst
ENSRNOT00000133772
resolver
enst
ENSRNOT00000161294
resolver
enst
ENSRNOT00055054751
resolver
enst
ENSRNOT00060026319
resolver
enst
ENSRNOT00065057159
resolver
genesymbol
Hexim1
resolver
genesymbol_syn
Clp1
resolver
uniprot_entry
HEXI1_RAT
resolver
amino_acid_sequence
MAEPLLSEHQHQPQTSNCTGAAVVHEEQNSERPPSAEERVPKEDSRWQSRASLQSGSRPGQEGDGGLKHQLPPLQTNACPELSCLEKGEKGQNGEDLSTGGASPSAEGEPMSESLVQPGHDSEATKLEAPVAGVEEPWGQQQRQLGKKKHRRRPSKKKRHWKPYYKLTWEEKKKFDEKQSLRASRVRAEMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTGLYPKRAAAKSDDTSDEDFVEEAGEEDGGSDGMGGDGSEFLQRDFSETYERYHAESLQNMSKQELIKEYLELEKCLSRKEDENNRLRLESKRLGGVDARVRELELELDRLRAENRQLLTENELHRQQERAPPSKFGD
uniprot
proteins
function
FUNCTION: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. {ECO:0000250|UniProtKB:O94992}.
uniprot
proteins
mass_dalton
40317
uniprot
proteins
protein_family
HEXIM family
uniprot
proteins
pubmed
12119119
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
356
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O94992}. Cytoplasm {ECO:0000250|UniProtKB:O94992}. Note=Binds alpha-importin and is mostly nuclear. {ECO:0000250|UniProtKB:O94992}.
uniprot
proteins