ENKD1
entrez
84080
canonical
uniprot
Q9H0I2
canonical
ensembl
ENSG00000124074
resolver
ensp
ENSP00000243878
resolver
ensp
ENSP00000680559
resolver
genesymbol
ENKD1
resolver
genesymbol_syn
C16orf48
resolver
hgnc
HGNC:25246
resolver
uniprot
Q6UWD7
resolver
uniprot_entry
ENKD1_HUMAN
resolver
uniprot_sec
Q6UWD7
resolver
amino_acid_sequence
MCEGPSRISGPIPPDPTLCPDNYRRPTSAQGRLEGNALKLDLLTSDRALDTTAPRGPCIGPGAGEILERGQRGVGDVLLQLEGISLGPGASLKRKDPKDHEKENLRRIREIQKRFREQERSREQGQPRPLKALWRSPKYDKVESRVKAQLQEPGPASGTESAHFLRAHSRCGPGLPPPHVSSPQPTPPGPEAKEPGLGVDFIRHNARAAKRAPRRHSCSLQVLAQVLEQQRQAQEHYNATQKGHVPHYLLERRDLWRREAEARKQSQPDPAMPPGHTRMPENQRLETLTKLLQSQSQLLRELVLLPAGADSLRAQSHRAELDRKLVQVEEAIKIFSRPKVFVKMDD
uniprot
proteins
function
FUNCTION: Microtubule-binding protein which regulates microtubule organization and stability (PubMed:35072334, PubMed:35197565). Promotes the stability of astral microtubules and facilitates the proper orientation of the mitotic spindle (PubMed:35197565). This allows the oriented division of basal keratinocytes and contributes to epidermal stratification (By similarity). Required for the assembly of both primary and motile cilia (PubMed:35301795). Destabilizes the interaction between CCP110 and CEP97 by competing with CEP97 for binding to CCP110 which promotes the removal of CCP110 and CEP97 from the mother centriole and allows the initiation of ciliogenesis (PubMed:35301795). {ECO:0000250|UniProtKB:Q7TSV9, ECO:0000269|PubMed:35072334, ECO:0000269|PubMed:35197565, ECO:0000269|PubMed:35301795}.
uniprot
proteins
mass_dalton
38759
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
35072334
uniprot
proteins
pubmed
35197565
uniprot
proteins
pubmed
35301795
uniprot
proteins
sequence_length
346
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:35072334, ECO:0000269|PubMed:35301795}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:35301795}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:35301795}. Cell projection, cilium {ECO:0000269|PubMed:35072334}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:35072334}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:35072334}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:35072334}. Note=Localized at the centrosome and accumulates at the parental centrioles during centriole duplication in cycling cells (PubMed:35301795). In ciliated cells, detected at the basal body of the cilium (PubMed:35301795). Localizes to the centrosome during interphase, to the primary cilium at G0, to the spindle poles during mitosis and to the centrosomes and central spindle during telophase and cytokinesis (PubMed:35072334). {ECO:0000269|PubMed:35072334, ECO:0000269|PubMed:35301795}.
uniprot
proteins