SRMS
entrez
6725
canonical
uniprot
Q9H3Y6
canonical
ensembl
ENSG00000125508
resolver
ensp
ENSP00000217188
resolver
enst
ENST00000217188
resolver
genesymbol
SRMS
resolver
genesymbol_syn
C20orf148
resolver
hgnc
HGNC:11298
resolver
uniprot_entry
SRMS_HUMAN
resolver
amino_acid_sequence
MEPFLRRRLAFLSFFWDKIWPAGGEPDHGTPGSLDPNTDPVPTLPAEPCSPFPQLFLALYDFTARCGGELSVRRGDRLCALEEGGGYIFARRLSGQPSAGLVPITHVAKASPETLSDQPWYFSGVSRTQAQQLLLSPPNEPGAFLIRPSESSLGGYSLSVRAQAKVCHYRVSMAADGSLYLQKGRLFPGLEELLTYYKANWKLIQNPLLQPCMPQKAPRQDVWERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGLRHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPPLLGFACQVAEGMSYLEEQRVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDVWSFGVLLHEVFTYGQCPYEGMTNHETLQQIMRGYRLPRPAACPAEVYVLMLECWRSSPEERPSFATLREKLHAIHRCHP
uniprot
proteins
ec_number
2.7.10.2
uniprot
proteins
function
FUNCTION: Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues (PubMed:23822091). Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues (PubMed:29496907). Phosphorylation of KHDRBS1 is EGF-dependent (PubMed:29496907). Phosphorylates OTUB1, promoting deubiquitination of RPTOR (PubMed:35927303). {ECO:0000269|PubMed:23822091, ECO:0000269|PubMed:29496907, ECO:0000269|PubMed:35927303}.
uniprot
proteins
mass_dalton
54507
uniprot
proteins
mutagenesis
MUTAGEN 223; /note="W->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:23822091"; MUTAGEN 258; /note="K->M: Loss of kinase activity. Exhibits a diffused cytoplasmic localization. No effect on interaction with KHDRBS1 or VIM but abolishes tyrosine phosphorylation of both substrates."; /evidence="ECO:0000269|PubMed:23822091, ECO:0000269|PubMed:29496907"; MUTAGEN 380; /note="Y->F: Significant reduction in phosphorylation."; /evidence="ECO:0000269|PubMed:23822091
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
SRC subfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
23822091
uniprot
proteins
pubmed
29496907
uniprot
proteins
pubmed
35927303
uniprot
proteins
sequence_length
488
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23822091, ECO:0000269|PubMed:29496907}. Note=Localizes to punctate cytoplasmic structures. {ECO:0000269|PubMed:23822091, ECO:0000269|PubMed:29496907}.
uniprot
proteins