P2rx2
entrez
231602
canonical
uniprot
Q8K3P1
canonical
ensembl
ENSMUSG00000029503
resolver
ensp
ENSMUSP00000054233
resolver
ensp
ENSMUSP00000108097
resolver
ensp
ENSMUSP00000142567
resolver
ensp
ENSMUSP00000143047
resolver
ensp
ENSMUSP00000143554
resolver
genesymbol
P2rx2
resolver
genesymbol_syn
P2x2
resolver
uniprot
Q3KP15
resolver
uniprot
Q3TYV0
resolver
uniprot
Q812E6
resolver
uniprot
Q812E7
resolver
uniprot_entry
P2RX2_MOUSE
resolver
uniprot_sec
Q3KP15
resolver
uniprot_sec
Q3TYV0
resolver
uniprot_sec
Q812E6
resolver
uniprot_sec
Q812E7
resolver
activity_regulation
ACTIVITY REGULATION: Fast activation by external ATP (By similarity). Exhibits slow desensitization during prolonged ATP activation (By similarity). Not sensitive to the ATP agonist:alpha/beta-methylene-ATP (By similarity). {ECO:0000250|UniProtKB:P49653, ECO:0000250|UniProtKB:Q9UBL9}.
uniprot
proteins
amino_acid_sequence
MAAAQPRLPAGAAMVRRLARGCWSAFWDYETPKVIVVRNRRLGFVHRMVQLLILLYFVWYVFIVQKSYQDSETGPESSIITKVKGITMSEHKVWDVEEYVKPPEGGSVVSIITRIEVTPSQTLGTCPESMRVHSSTCHLDDDCVAGQLDMQGNGIRTGRCVPYYHGDSKTCEVSAWCPVEDGTSENHFLGKMAPNFTILIKNSIHYPKFKFSKGNIASQKSDYLKHCTFDQDSDPYCPIFRLGFIVEQAGENFTELAHKGGVIGVIINWNCDLDLSESECNPKYSFRRLDPKYDPASSGYNFRFAKYYKINGTTTTRTLIKAYGIRIDVIVHGQAGKFSLIPTIINLATALTSIGVGSFLCDWILLTFMNKNKLYSHKKFDKVRTPRHPSSRWPVTLALVLGQIPPPPSHYSQDQPPSLPSGEGPALGEGAELPLAVQPPRSCSSSALTEQVVDTLDQHMGQRPPVPEPSQQDSTSTDPKGLAQL
uniprot
proteins
function
FUNCTION: ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and calcium (By similarity). Activation by extracellular ATP induces a variety of cellular responses, such as excitatory postsynaptic responses in sensory neurons, neuromuscular junctions (NMJ) formation, hearing, perception of taste and peristalsis. In the inner ear, regulates sound transduction and auditory neurotransmission, outer hair cell electromotility, inner ear gap junctions, and K(+) recycling. Mediates synaptic transmission between neurons and from neurons to smooth muscle (PubMed:12917379, PubMed:12937291, PubMed:15961431, PubMed:16322458, PubMed:17706883, PubMed:23345450). {ECO:0000250|UniProtKB:Q9UBL9, ECO:0000269|PubMed:12917379, ECO:0000269|PubMed:12937291, ECO:0000269|PubMed:15961431, ECO:0000269|PubMed:16322458, ECO:0000269|PubMed:17706883, ECO:0000269|PubMed:23345450}.
uniprot
proteins
mass_dalton
53937
uniprot
proteins
protein_family
P2X receptor family
uniprot
proteins
pubmed
12917379
uniprot
proteins
pubmed
12937291
uniprot
proteins
pubmed
14672995
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15961431
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16322458
uniprot
proteins
pubmed
16467187
uniprot
proteins
pubmed
17706883
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23345450
uniprot
proteins
sequence_length
485
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17706883}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P56373}.
uniprot
proteins
transmembrane_region
TRANSMEM 44..64; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P56373"; TRANSMEM 340..360; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P56373
uniprot
proteins