DEK
entrez
7913
canonical
uniprot
P35659
canonical
ensembl
ENSG00000124795
resolver
ensp
ENSP00000244776
resolver
ensp
ENSP00000422380
resolver
ensp
ENSP00000498335
resolver
ensp
ENSP00000498653
resolver
ensp
ENSP00000659370
resolver
enst
ENST00000515770
resolver
genesymbol
DEK
resolver
hgnc
HGNC:2768
resolver
uniprot
B2R6K6
resolver
uniprot
B4DN37
resolver
uniprot
H0Y8X0
resolver
uniprot
Q5TGV4
resolver
uniprot
Q5TGV5
resolver
uniprot_entry
DEK_HUMAN
resolver
uniprot_entry
H0Y8X0_HUMAN
resolver
uniprot_sec
B2R6K6
resolver
uniprot_sec
B4DN37
resolver
uniprot_sec
Q5TGV4
resolver
uniprot_sec
Q5TGV5
resolver
amino_acid_sequence
MSASAPAAEGEGTPTQPASEKEPEMPGPREESEEEEDEDDEEEEEEEKEKSLIVEGKREKKKVERLTMQVSSLQREPFTIAQGKGQKLCEIERIHFFLSKKKTDELRNLHKLLYNRPGTVSSLKKNVGQFSGFPFEKGSVQYKKKEEMLKKFRNAMLKSICEVLDLERSGVNSELVKRILNFLMHPKPSGKPLPKSKKTCSKGSKKERNSSGMARKAKRTKCPEILSDESSSDEDEKKNKEESSDDEDKESEEEPPKKTAKREKPKQKATSKSKKSVKSANVKKADSSTTKKNQNSSKKESESEDSSDDEPLIKKLKKPPTDEELKETIKKLLASANLEEVTMKQICKKVYENYPTYDLTERKDFIKTTVKELIS
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving DEK is found in a subset of acute myeloid leukemia (AML); also known as acute non-lymphocytic leukemia (PubMed:1549122). Translocation t(6;9)(p23;q34) with NUP214/CAN (PubMed:1549122). It results in the formation of a DEK-NUP214 fusion gene (PubMed:1549122). {ECO:0000269|PubMed:1549122}.
uniprot
proteins
function
FUNCTION: Involved in chromatin organization. {ECO:0000269|PubMed:17524367}.
uniprot
proteins
mass_dalton
42674
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CK2. Phosphorylation fluctuates during the cell cycle with a moderate peak during G(1) phase, and weakens the binding of DEK to DNA. {ECO:0000269|PubMed:15199154}.
uniprot
proteins
pubmed
11118221
uniprot
proteins
pubmed
12140263
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15199154
uniprot
proteins
pubmed
15238633
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1549122
uniprot
proteins
pubmed
16603771
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17524367
uniprot
proteins
pubmed
18227428
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19695025
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28190768
uniprot
proteins
sequence_length
375
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17524367, ECO:0000269|PubMed:19695025}. Note=Enriched in regions where chromatin is decondensed or sparse in the interphase nuclei.
uniprot
proteins