Pawr
entrez
114774
canonical
uniprot
Q925B0
canonical
ensembl
ENSMUSG00000035873
resolver
ensp
ENSMUSP00000092951
resolver
genesymbol
Pawr
resolver
genesymbol_syn
Par4
resolver
uniprot
Q0ZHI4
resolver
uniprot
Q2HYJ1
resolver
uniprot_entry
PAWR_MOUSE
resolver
uniprot_sec
Q0ZHI4
resolver
uniprot_sec
Q2HYJ1
resolver
amino_acid_sequence
MATGGYRSGGSTTTDFLEEWKAKREKMRAKQNPAGPGSSGGDPAAKSPAGSLTPTAVAGTSELNHGPAGAAAPAAPAPGALNCAHGSSTLPRAAPGSRRAEDECPSAAAASGAPGSRGDEEEPDSAREKGRSSGPSARKGKGQIEKRKLREKRRSTGVVNIPAAECLDEYEDDEAGQKERKREDAITQQNTIQNEAATLPDPGTSYLPQDPSRTVPGRYKSTTSAPEDEISNRYPRTDRSGFSRHNRDANAPASFSSSSTLEKRIEDLEKEVVRERQENLRLVRLMQDKEEMIGKLKEEIDLLNRDLDDMEDENEQLKQENKTLLKVVGQLTR
uniprot
proteins
function
FUNCTION: Pro-apoptotic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Also seems to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1 (By similarity). {ECO:0000250, ECO:0000269|PubMed:15606896}.
uniprot
proteins
mass_dalton
35908
uniprot
proteins
post_translational_modification
PTM: Preferentially phosphorylated at the Thr-156 by PKC in cancer cells. {ECO:0000250}.
uniprot
proteins
pubmed
15606896
uniprot
proteins
pubmed
16369487
uniprot
proteins
pubmed
16520897
uniprot
proteins
pubmed
20561531
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
333
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis. Nuclear localization includes nucleoplasm and PML nuclear bodies (By similarity). {ECO:0000250}.
uniprot
proteins