PRXL2A
entrez
84293
canonical
uniprot
Q9BRX8
canonical
ensembl
ENSG00000122378
resolver
ensp
ENSP00000361259
resolver
ensp
ENSP00000361261
resolver
ensp
ENSP00000361262
resolver
ensp
ENSP00000478152
resolver
ensp
ENSP00000482445
resolver
ensp
ENSP00000540498
resolver
ensp
ENSP00000540509
resolver
genesymbol
PRXL2A
resolver
genesymbol_syn
C10orf58
resolver
genesymbol_syn
FAM213A
resolver
genesymbol_syn
PAMM
resolver
hgnc
HGNC:28651
resolver
uniprot
B2RD81
resolver
uniprot
Q6UW08
resolver
uniprot
Q8N2K3
resolver
uniprot
Q8NBK9
resolver
uniprot
Q96JR0
resolver
uniprot_entry
PXL2A_HUMAN
resolver
uniprot_sec
B2RD81
resolver
uniprot_sec
Q6UW08
resolver
uniprot_sec
Q8N2K3
resolver
uniprot_sec
Q8NBK9
resolver
uniprot_sec
Q96JR0
resolver
amino_acid_sequence
MSFLQDPSFFTMGMWSIGAGALGAAALALLLANTDVFLSKPQKAALEYLEDIDLKTLEKEPRTFKAKELWEKNGAVIMAVRRPGCFLCREEAADLSSLKSMLDQLGVPLYAVVKEHIRTEVKDFQPYFKGEIFLDEKKKFYGPQRRKMMFMGFIRLGVWYNFFRAWNGGFSGNLEGEGFILGGVFVVGSGKQGILLEHREKEFGDKVNLLSVLEAAKMIKPQTLASEKK
uniprot
proteins
function
FUNCTION: Involved in redox regulation of the cell (PubMed:19951071, PubMed:26438880). Acts as an antioxidant (PubMed:19951071, PubMed:26438880). Inhibits TNFSF11-induced NFKB1 and JUN activation and osteoclast differentiation (PubMed:19951071). May affect bone resorption and help to maintain bone mass (PubMed:19951071). Acts as a negative regulator of macrophage-mediated inflammation by inhibiting macrophage production of inflammatory cytokines, probably through suppression of the MAPK signaling pathway (PubMed:26438880). {ECO:0000269|PubMed:19951071, ECO:0000269|PubMed:26438880}.
uniprot
proteins
mass_dalton
25764
uniprot
proteins
mutagenesis
MUTAGEN 85; /note="C->G: Decrease of about 38% in antioxidant activity in TNFSF11-stimulated osteoclasts and reduced inhibition of TNFSF11-induced osteoclast formation. Does not change anti-inflammatory properties."; /evidence="ECO:0000269|PubMed:19951071, ECO:0000269|PubMed:26438880"; MUTAGEN 88; /note="C->G: Decrease of about 125% in antioxidant activity in TNFSF11-stimulated osteoclasts and reduced inhibition of TNFSF11-induced osteoclast formation."; /evidence="ECO:0000269|PubMed:19951071
uniprot
proteins
protein_family
PRXL2A subfamily
uniprot
proteins
protein_family
Peroxiredoxin-like PRXL2 family
uniprot
proteins
pubmed
11483580
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
19951071
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26438880
uniprot
proteins
sequence_length
229
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19951071}. Secreted {ECO:0000269|PubMed:26438880}. Note=Secreted from mature adipocytes but not from preadipocytes. {ECO:0000269|PubMed:26438880}.
uniprot
proteins