Cd80
entrez
12519
canonical
uniprot
Q00609
canonical
ensembl
ENSMUSG00000075122
resolver
ensp
ENSMUSP00000097404
resolver
ensp
ENSMUSP00000156252
resolver
ensp
ENSMUSP00000236989
resolver
ensp
ENSMUSP00000334973
resolver
genesymbol
Cd80
resolver
genesymbol_syn
B7
resolver
genesymbol_syn
Qoo609
resolver
uniprot
Q549R2
resolver
uniprot
Q61332
resolver
uniprot_entry
CD80_MOUSE
resolver
uniprot_entry
Q549R2_MOUSE
resolver
uniprot_sec
Q61332
resolver
amino_acid_sequence
MACNCQLMQDTPLLKFPCPRLILLFVLLIRLSQVSSDVDEQLSKSVKDKVLLPCRYNSPHEDESEDRIYWQKHDKVVLSVIAGKLKVWPEYKNRTLYDNTTYSLIILGLVLSDRGTYSCVVQKKERGTYEVKHLALVKLSIKADFSTPNITESGNPSADTKRITCFASGGFPKPRFSWLENGRELPGINTTISQDPESELYTISSQLDFNTTRNHTIKCLIKYGDAHVSEDFTWEKPPEDPPDSKNTLVLFGAGFGAVITVVVIVVIIKCFCKHRSCFRRNEASRETNNSLTFGPEEALAEQTVFL
uniprot
proteins
function
FUNCTION: Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation (PubMed:16339518, PubMed:1714935). Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells by acting as a ligand for the CD28 receptor which is constitutively expressed on the cell surface of T-cells (PubMed:16339518). In turn, activates different signaling pathways such as NF-kappa-B or MAPK leading to the production of different cytokines (By similarity). Also acts as an inhibitor of T-cell activation by acting as a ligand for CTLA4, a decoy receptor, thereby blocking CD28-mediated T-cell priming (By similarity). In addition, CD28/CD80 costimulatory signal stimulates glucose metabolism and ATP synthesis of T-cells by activating the PI3K/Akt signaling pathway (By similarity). Also acts as a regulator of PDL1/PDCD1 interactions to limit excess engagement of PDL1 and its inhibitory role in immune responses (By similarity). Expressed on B-cells, plays a critical role in regulating interactions between B-cells and T-cells in both early and late germinal center responses, which are crucial for the generation of effective humoral immune responses (PubMed:22450810). {ECO:0000250|UniProtKB:P33681, ECO:0000269|PubMed:16339518, ECO:0000269|PubMed:1714935, ECO:0000269|PubMed:22450810}.
uniprot
proteins
mass_dalton
34590
uniprot
proteins
pubmed
16339518
uniprot
proteins
pubmed
1714935
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
22450810
uniprot
proteins
pubmed
7513163
uniprot
proteins
pubmed
7686531
uniprot
proteins
sequence_length
306
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16339518}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P33681}.
uniprot
proteins
transmembrane_region
TRANSMEM 247..268; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins