Slc9a4
entrez
110895
canonical
uniprot
Q8BUE1
canonical
ensembl
ENSMUSG00000026065
resolver
ensp
ENSMUSP00000027233
resolver
ensp
ENSMUSP00000281071
resolver
ensp
ENSMUSP00000281076
resolver
ensp
ENSMUSP00000281078
resolver
enst
ENSMUST00000027233
resolver
genesymbol
Slc9a4
resolver
genesymbol_syn
Nhe4
resolver
uniprot
Q3TCU9
resolver
uniprot
Q9WUJ6
resolver
uniprot_entry
SL9A4_MOUSE
resolver
uniprot_sec
Q3TCU9
resolver
uniprot_sec
Q9WUJ6
resolver
activity_regulation
ACTIVITY REGULATION: Up-regulated in response to high extracellular sodium concentration. {ECO:0000269|PubMed:32372285}.
uniprot
proteins
amino_acid_sequence
MGPAMFMAFRLWNWLLLLAVLTRSEATSYVNESSNPTAQQAPDARFAASSSDPDEGISVFELDYDYVQIPYEVTLWILLASLAKIGFHLYHRLPHLMPESCLLIIVGALVGGIIFGTHHKSPPVMDSSIYFLYLLPPIVLESGYFMPTRPFFENIGSILWWAGLGALINAFGIGLSLYFICQIKAFGLGDINLLHNLLFGSLISAVDPVAVLAVFEEARVNEQLYMMIFGEALLNDGISVVLYNILIAFTKMHKFEDIEAVDILAGCARFVIVGCGGVFFGIIFGFISAFITRFTQNISAIEPLIVFMFSYLSYLAAETLYLSGILAITACAVTMKKYVEENVSQTSYTTIKYFMKMLSSVSETLIFIFMGVSTIGKNHEWNWAFICFTLLFCQIWRAISVFTLFYVSNQFRTFPFSIKDQFIIFYSGVRGAGSFSLAFLLPLSLFPRKKLFVTATLVVTYFTVFFQGITIGPLVRYLDVRKTNKKESINEELHSRLMDHLKAGIEDVCGQWSHYQVRDKFKKFDHRYLRKILIRRNLPKSSIVSLYKKLEMKQAIEMVETGILSSVASPTPYQSERIQGIKRLSPEDVESMRDILTRSMYQVRQRTLSYNKYNLKPQTSEKQAKEILIRRQNTLRESMRKGQSLPWGKPAGTKNFRYLSFPYSNPQAARREARAAEPTDDDGTDSGFQPLMFSIHSRAGSLQERRQTQAVIPMKRLQRGEKALSFSYRSNTSWEDQAGWRRMDVLRPKPLFYAVAEEYDSGEQTEEETSAILSRWTAEHRHSTEHHKSHSPLLHRK
uniprot
proteins
function
FUNCTION: Electroneutral antiporter that exchanges sodium for protons or ammonium ions at the basolateral membrane of epithelia to regulate cell volume and intracellular pH upon hypertonic conditions (PubMed:15684419, PubMed:20484819). As part of transcellular ammonia transport in renal tubules, mediates basolateral ammonium extrusion in the medullary thick ascending limb, regulating the corticopapillary ammonium gradient and overall renal acid excretion (PubMed:20484819). Mediates sodium:proton exchange in gastric parietal cells secondary to cAMP-dependent acid secretion and hyperosmolarity. Possibly coupled to chloride:bicarbonate antiporter, enables loading of parietal cells with sodium and chloride ions to maintain cell volume and normal gastric acid secretion (PubMed:15684419). Functions as a sodium sensor in neurons of organum vasculosum of the lamina terminalis where it regulates water intake in response to increased sodium concentration in body fluids (PubMed:32372285). {ECO:0000269|PubMed:15684419, ECO:0000269|PubMed:20484819, ECO:0000269|PubMed:32372285}.
uniprot
proteins
mass_dalton
90937
uniprot
proteins
post_translational_modification
PTM: May be phosphorylated. {ECO:0000250}.
uniprot
proteins
protein_family
Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
uniprot
proteins
pubmed
10666043
uniprot
proteins
pubmed
11880326
uniprot
proteins
pubmed
12493726
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15684419
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20484819
uniprot
proteins
pubmed
32372285
uniprot
proteins
pubmed
9691122
uniprot
proteins
sequence_length
797
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:12493726}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:12493726}; Multi-pass membrane protein {ECO:0000255}. Zymogen granule membrane {ECO:0000250|UniProtKB:P26434}; Multi-pass membrane protein {ECO:0000255}. Note=Enrichment at apical or basolateral membrane may be tissue-dependent. {ECO:0000305|PubMed:12493726}.
uniprot
proteins
transmembrane_region
TRANSMEM 95..114; /note="Helical; Name=C/M3"; /evidence="ECO:0000255"; TRANSMEM 128..148; /note="Helical; Name=D/M4"; /evidence="ECO:0000255"; TRANSMEM 155..175; /note="Helical; Name=E/M5"; /evidence="ECO:0000255"; TRANSMEM 195..215; /note="Helical; Name=F/M5A"; /evidence="ECO:0000255"; TRANSMEM 227..247; /note="Helical; Name=G/M5B"; /evidence="ECO:0000255"; TRANSMEM 271..291; /note="Helical; Name=H/M6"; /evidence="ECO:0000255"; TRANSMEM 305..325; /note="Helical; Name=I/M7"; /evidence="ECO:0000255"; TRANSMEM 353..373; /note="Helical; Name=J/M8"; /evidence="ECO:0000255"; TRANSMEM 385..405; /note="Helical; Name=K/M9"; /evidence="ECO:0000255"; TRANSMEM 451..471; /note="Helical; Name=M/M10"; /evidence="ECO:0000255
uniprot
proteins