HUS1
entrez
3364
canonical
uniprot
O60921
canonical
ensembl
ENSG00000136273
resolver
ensp
ENSP00000258774
resolver
ensp
ENSP00000416588
resolver
genesymbol
HUS1
resolver
hgnc
HGNC:5309
resolver
uniprot
A4D2F2
resolver
uniprot
B4DFI9
resolver
uniprot_entry
A4D2F2_HUMAN
resolver
uniprot_entry
HUS1_HUMAN
resolver
uniprot_sec
B4DFI9
resolver
amino_acid_sequence
MKFRAKIVDGACLNHFTRISNMIAKLAKTCTLRISPDKLNFILCDKLANGGVSMWCELEQENFFNEFQMEGVSAENNEIYLELTSENLSRALKTAQNARALKIKLTNKHFPCLTVSVELLSMSSSSRIVTHDIPIKVIPRKLWKDLQEPVVPDPDVSIYLPVLKTMKSVVEKMKNISNHLVIEANLDGELNLKIETELVCVTTHFKDLGNPPLASESTHEDRNVEHMAEVHIDIRKLLQFLAGQQVNPTKALCNIVNNKMVHFDLLHEDVSLQYFIPALS
uniprot
proteins
function
FUNCTION: Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:21659603). The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:21659603). Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:21659603). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates (PubMed:21659603). The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (PubMed:21659603). {ECO:0000269|PubMed:21659603}.
uniprot
proteins
mass_dalton
31691
uniprot
proteins
protein_family
HUS1 family
uniprot
proteins
pubmed
10359610
uniprot
proteins
pubmed
10777662
uniprot
proteins
pubmed
10846170
uniprot
proteins
pubmed
10884395
uniprot
proteins
pubmed
11077446
uniprot
proteins
pubmed
11573955
uniprot
proteins
pubmed
12578958
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14500360
uniprot
proteins
pubmed
14611806
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15314187
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15556996
uniprot
proteins
pubmed
15871698
uniprot
proteins
pubmed
15897895
uniprot
proteins
pubmed
16216273
uniprot
proteins
pubmed
21659603
uniprot
proteins
pubmed
31776186
uniprot
proteins
pubmed
36841485
uniprot
proteins
pubmed
9524127
uniprot
proteins
pubmed
9878245
uniprot
proteins
sequence_length
280
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10846170, ECO:0000269|PubMed:11077446}. Cytoplasm, cytosol {ECO:0000269|PubMed:11077446}. Note=In discrete nuclear foci upon DNA damage (PubMed:11077446). According to PubMed:11077446, localized also in the cytoplasm (PubMed:11077446). DNA damage induces its nuclear translocation (PubMed:11077446). Shuttles between the nucleus and the cytoplasm (PubMed:11077446). {ECO:0000269|PubMed:11077446}.
uniprot
proteins