Kcnd1
entrez
16506
canonical
uniprot
Q03719
canonical
ensembl
ENSMUSG00000009731
resolver
ensp
ENSMUSP00000009875
resolver
enst
ENSMUST00000009875
resolver
genesymbol
Kcnd1
resolver
uniprot
A2AEX0
resolver
uniprot
Q8CC68
resolver
uniprot_entry
A2AEX0_MOUSE
resolver
uniprot_entry
KCND1_MOUSE
resolver
uniprot_sec
Q8CC68
resolver
amino_acid_sequence
MAAGVATWLPFARAAAVGWLPLAQQPLPPAPEVKASRGDEVLVVNVSGRRFETWKNTLDRYPDTLLGSSEKEFFYDAESGEYFFDRDPDMFRHVLNFYRTGRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRKKENAERLAEDEEAEQAGEGPALPAGSSLRQRLWRAFENPHTSTAALVFYYVTGFFIAVSVIANVVETIPCRGTPRWPSKEQSCGDRFPTAFFCMDTACVLIFTGEYLLRLFAAPSRCRFLRSVMSLIDVVAILPYYIGLFVPKNDDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGTSKTNFTSIPAAFWYTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQQKVRLARIRLAKSGTTNAFLQYKQNGGLEDSGSGDGQMLCVRSRSAFEQQHHHLLHCLEKTTCHEFTDELTFSEALGAVSLGGRTSRSTSVSSQPMGPGSLFSSCCSRRVNRRAIRLANSTASVSRGSMQELDTLAGLRRSPAPQTRSSLNAKPHDSLDLNCDSRDFVAAIISIPTPPANTPDESQPSSPSGGGGSGGTPNTTLRNSSLGTPCLLPETVKISSL
uniprot
proteins
function
FUNCTION: A-type voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes in the brain (PubMed:28560311). Mediates A-type current I(SA) in suprachiasmatic nucleus (SCN) neurons (PubMed:28560311). Exhibits a low-threshold A-type current with a hyperpolarized steady-state inactivation midpoint and the recovery process was steeply voltage-dependent, with recovery being markedly faster at more negative potentials (PubMed:2034678). May regulates repetitive firing rates in the suprachiasmatic nucleus (SCN) neurons and circadian rhythms in neuronal excitability and behavior (PubMed:28560311). Contributes to the regulation of the circadian rhythm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity (PubMed:28560311). The regulatory subunit KCNIP1 modulates the kinetics of channel inactivation, increases the current amplitudes and accelerates recovery from inactivation, shifts activation in a depolarizing direction (PubMed:11423117). The regulatory subunit DPP10 decreases the voltage sensitivity of the inactivation channel gating (By similarity). {ECO:0000250|UniProtKB:Q9NSA2, ECO:0000269|PubMed:11423117, ECO:0000269|PubMed:2034678, ECO:0000269|PubMed:28560311}.
uniprot
proteins
mass_dalton
71698
uniprot
proteins
protein_family
D (Shal) (TC 1.A.1.2) subfamily
uniprot
proteins
protein_family
Kv4.1/KCND1 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
11423117
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19713751
uniprot
proteins
pubmed
2034678
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28560311
uniprot
proteins
sequence_length
651
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9NZV8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NZV8}.
uniprot
proteins
transmembrane_region
TRANSMEM 184..205; /note="Helical; Name=Segment S1"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 231..252; /note="Helical; Name=Segment S2"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 264..284; /note="Helical; Name=Segment S3"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 288..308; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 324..345; /note="Helical; Name=Segment S5"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 387..415; /note="Helical; Name=Segment S6"; /evidence="ECO:0000250|UniProtKB:P63142
uniprot
proteins