Gorasp1
entrez
74498
canonical
uniprot
Q91X51
canonical
ensembl
ENSMUSG00000032513
resolver
ensp
ENSMUSP00000035099
resolver
enst
ENSMUST00000035099
resolver
genesymbol
Gorasp1
resolver
uniprot
Q3TCN5
resolver
uniprot
Q9D3L9
resolver
uniprot_entry
GORS1_MOUSE
resolver
uniprot_entry
Q3TCN5_MOUSE
resolver
uniprot_sec
Q9D3L9
resolver
amino_acid_sequence
MGLGASSEQPAGGEGFHLHGVQENSPAQQAGLEPYFDFIITIGHSRLNKENDTLKALLKANVEKPVKLEVFNMKTMKVREVEVVPSNMWGGQGLLGASVRFCSFRRASEHVWHVLDVEPSSPAALAGLCPYTDYIVGSDQILQESEDFFTLIESHEGKPLKLMVYNSESDSCREVTVTPNAAWGGEGSLGCGIGYGYLHRIPTQPSSQHKKPPGATPPGTPATTSQLTAFPLGAPPPWPIPQDSSGPELGSRQSDFMEALPQVPGSFMEGQLLGPGSPSHGAADCGGCLRAMEIPLQPPPPVQRVMDPGFLDVSGMSLLDSSNISVCPSLSSSTVLTSTAVSVSGPEDIGSSSSSHERGGEATWSGSEFEISFPDSPGAQAQADHLPRLTLPDGLTSAASPEEGLSAELLEAQTEEPADTASLDCRAETEGRASQAQATPDPEPGL
uniprot
proteins
function
FUNCTION: Key structural protein of the Golgi apparatus (PubMed:32573693). The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon (PubMed:32573693). Acting in concert with GORASP2/GRASP55, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks (PubMed:32573693). However, other studies suggest that GORASP1 plays an important role in assembly and membrane stacking of the cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis (By similarity). Caspase-mediated cleavage of GORASP1 is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (By similarity). Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (By similarity). {ECO:0000250|UniProtKB:O35254, ECO:0000250|UniProtKB:Q9BQQ3, ECO:0000269|PubMed:32573693}.
uniprot
proteins
mass_dalton
46882
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CDC2/B1 and PLK kinases during mitosis. Phosphorylation cycle correlates with the cisternal stacking cycle. Phosphorylation of the homodimer prevents the association of dimers into higher-order oligomers, leading to cisternal unstacking. {ECO:0000250|UniProtKB:O35254}.; PTM: Target for caspase-3 cleavage during apoptosis. The cleavage contributes to Golgi fragmentation and occurs very early in the execution phase of apoptosis. {ECO:0000250|UniProtKB:O35254}.; PTM: Myristoylated. {ECO:0000250|UniProtKB:O35254}.
uniprot
proteins
protein_family
GORASP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32573693
uniprot
proteins
sequence_length
446
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:O35254}; Peripheral membrane protein {ECO:0000250|UniProtKB:O35254}; Cytoplasmic side {ECO:0000250|UniProtKB:O35254}.
uniprot
proteins