Mief1
entrez
315141
canonical
uniprot
Q5XIS8
canonical
ensembl
ENSRNOG00000017553
resolver
ensembl
ENSRNOG00055029688
resolver
ensembl
ENSRNOG00060021595
resolver
ensembl
ENSRNOG00065033368
resolver
ensp
ENSRNOP00000112118
resolver
ensp
ENSRNOP00055042377
resolver
ensp
ENSRNOP00060030866
resolver
ensp
ENSRNOP00065047211
resolver
enst
ENSRNOT00000146818
resolver
enst
ENSRNOT00055051417
resolver
enst
ENSRNOT00060037452
resolver
enst
ENSRNOT00065057370
resolver
genesymbol
Mief1
resolver
genesymbol_syn
Mid51
resolver
genesymbol_syn
Smcr7l
resolver
uniprot_entry
MID51_RAT
resolver
amino_acid_sequence
MAGAGERKGKKDDNGIGTAIDFVLSNARLVLGVGGAAMLGIATLAVKRMYDRAISAPTSPTRLSHSGKRSWEEPNWMGSPRLLNRDMKTGLSRSLQTLPTDSSAFDTDTFCPPRPKPLARRGQVDLKKSRLRMSLQEKLLSYYRNRAAIPAGEQARAKQAAVDICAELRSFLRAKLPDMPLRDMYLSGSLYDDLQVVTADHIQLIVPLVLEQNLWSCIPGEDTIMNIPGFFLVRRENPEYFPRGSSYWDRCVVGGYLSPKTVADTFEKVVAGSINWPAIGSLLDYVIRPAPPPEALTLEVQYERDKHLVIDFLPSVTLGDTVLVARPHRLAQYDNLWRLSLRPAETARLRALDQADSGCRSLCLKILKAICKSTPALGHLTASQLTNVILHLSQEEADWSPDMLADRFLQALRGLISYLEAGVLPSALNPKVNLFAELTPHEIDELGYTLYCSLSEPEVLLQT
uniprot
proteins
function
FUNCTION: Mitochondrial outer membrane protein which regulates mitochondrial fission/fusion dynamics. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface independently of the mitochondrial fission FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L oligomerization. Binds ADP and can also bind GDP, although with lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits DNM1L GTPase activity in the absence of bound ADP. Requires ADP to stimulate DNM1L GTPase activity and the assembly of DNM1L into long, oligomeric tubules with a spiral pattern, as opposed to the ring-like DNM1L oligomers observed in the absence of bound ADP. Does not require ADP for its function in recruiting DNM1L. {ECO:0000250|UniProtKB:Q9NQG6}.
uniprot
proteins
mass_dalton
51309
uniprot
proteins
protein_family
MID49/MID51 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
463
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9NQG6}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9NQG6}.
uniprot
proteins
transmembrane_region
TRANSMEM 24..46; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins