Nde1
entrez
83836
canonical
uniprot
Q9ES39
canonical
ensembl
ENSRNOG00000058007
resolver
ensembl
ENSRNOG00055005251
resolver
ensembl
ENSRNOG00060012569
resolver
ensembl
ENSRNOG00065002655
resolver
ensp
ENSRNOP00000073786
resolver
ensp
ENSRNOP00055006366
resolver
ensp
ENSRNOP00060016810
resolver
ensp
ENSRNOP00065002460
resolver
enst
ENSRNOT00000086392
resolver
enst
ENSRNOT00055008415
resolver
enst
ENSRNOT00060021308
resolver
enst
ENSRNOT00065003566
resolver
genesymbol
Nde1
resolver
genesymbol_syn
Nude
resolver
genesymbol_syn
Nude1
resolver
uniprot
Q642F3
resolver
uniprot_entry
NDE1_RAT
resolver
uniprot_sec
Q642F3
resolver
amino_acid_sequence
MEDSGKTFGSEEEETNYWRDLAMTYKQRAENTQEELREFQEGSREYEAELETQLQQAETRNRDLLSENNRLRMELESVKEKFEMQHSEGYRQISALEDDLAHTKAIKDQLQKYIRELEQANDDLERAKRATIMSLEDFEQRLNQAIERNAFLESELDEKENLLESVQRLKDEARDLRQELAVQQKQDKPRTPMPSSGETKRTDMAVQATGSAPSTPITHQGSSSGLNTPETFRCGLGSPSSGTPLTPAARISALNIVGDLLRKVGALESKLASCKNFMYDQSPSRKSGPALGRGTKNRDGIDRRPGSTAVGDKGSGKRLEFAKPSSQLSSPALPSTQGVVKLLL
uniprot
proteins
function
FUNCTION: Required for centrosome duplication and formation and function of the mitotic spindle. Essential for the development of the cerebral cortex. May regulate the production of neurons by controlling the orientation of the mitotic spindle during division of cortical neuronal progenitors of the proliferative ventricular zone of the brain. Orientation of the division plane perpendicular to the layers of the cortex gives rise to two proliferative neuronal progenitors whereas parallel orientation of the division plane yields one proliferative neuronal progenitor and a postmitotic neuron. A premature shift towards a neuronal fate within the progenitor population may result in an overall reduction in the final number of neurons and an increase in the number of neurons in the deeper layers of the cortex. Acts as a RAB9A/B effector that tethers RAB9-associated late endosomes to the dynein motor for their retrograde transport to the trans-Golgi network. {ECO:0000250|UniProtKB:Q9NXR1}.
uniprot
proteins
mass_dalton
38528
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in mitosis (By similarity). Phosphorylation at Thr-246 is essential for the G2/M transition (By similarity). {ECO:0000250|UniProtKB:Q9CZA6, ECO:0000250|UniProtKB:Q9NXR1}.
uniprot
proteins
protein_family
NudE family
uniprot
proteins
pubmed
10940388
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
344
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Cleavage furrow {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9NXR1}. Note=Localizes to the interphase and S phase centrosome. During mitosis, partially associated with the mitotic spindle. Concentrates at the plus ends of microtubules coincident with kinetochores in metaphase and anaphase in a CENPF-dependent manner. Also localizes to the cleavage furrow during cytokinesis (By similarity). Also localizes to the cleavage furrow during cytokinesis. Colocalizes with RAB9A to membrane vesicles (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q9NXR1}.
uniprot
proteins