Dsc1
entrez
13505
canonical
uniprot
P55849
canonical
ensembl
ENSMUSG00000044322
resolver
ensp
ENSMUSP00000042303
resolver
ensp
ENSMUSP00000153639
resolver
enst
ENSMUST00000038710
resolver
genesymbol
Dsc1
resolver
uniprot
E9QJX2
resolver
uniprot
F6SP97
resolver
uniprot
Q2VPA9
resolver
uniprot
Q32ME9
resolver
uniprot_entry
DSC1_MOUSE
resolver
uniprot_entry
F6SP97_MOUSE
resolver
uniprot_entry
Q2VPA9_MOUSE
resolver
uniprot_entry
Q32ME9_MOUSE
resolver
uniprot_sec
E9QJX2
resolver
amino_acid_sequence
MAVACAAPGSTFSKQLLFFLLVLVLFCDACQKVSLHVPSHLKAETPVGKVNLEECLKSPSLILSSDPAFRILEDGTIYTTHDLLLSSEKRGFSILLSDGQGQEQKKLEVVLSAREKKVFRKRHTKEPVHNRSKRRWAPIPCSLMENSLGPFPQHIQQIQSDAAQNYTIFYSISGPGVDKEPYNLFYIEKDTGDIYCTRSIDREQYDQFLVYGYATTADGYAPDYPLPLLFKVEDDNDNAPYFETKLTVFSVPENCRSGTSVGQVTAIDKDEPGTLHTRLKYKILQQIPDQPKHFSIHPDTGVITTTTPLLDREKCDTYKLVMEVRDMGGQPFGLFTTGTITISLEDENDNSPYFTQTSYTTEVEENRIDVEILRMVVHDQDLPNTPHSKAVYTILKGNENGNFKITTDPNTNEGVLCVVKPLNYEVSRQVTLQIGVLNEAQFTNAANAQPPTMCTTTVTVKIKDRDEGPECQPPVKVIQSKDGLPAGQELLGYKAVDPETSSGEGLRYEMVGDEDNWFEINKITGDLRTVKVLDRESKFVKNNQYNISVVATDTAGRSCTGTLVVLLEDFNDHPPQIDKEVTICQQEKDFAVLEPIDLDGPDNGPPFQFLLDNSSSKLWTLESQDGKRAILRQRHNLNYNYYSVPIQIQDRHGFSAKHVLSVRVCDCTTPTECRMAVKEERDAKPNIILGKWAILAMVLGSALLLCILFTCFCVTTTKRTVKKCFPDDVAQQNLIVSNTEGPGEEVTEANIRLPTQTANICDTSMSVGTLGGQGIKTQQSFEMVKGGHTLESHKGGVLGAAEPGRYAYTDWQTFTQPRLGEKVYLCGQAEEHKHCEDYVRPYNYEGKGSMAGSVGCCSDRQEEEGLEFLDQLEPKFRTLAKTCVKK
uniprot
proteins
function
FUNCTION: A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:11714727). Required for desmosome adhesion strength between the granular layers of the epidermis, as a result moderates epidermal proliferation and differentiation (PubMed:11714727). Is therefore required to maintain postnatal epidermal barrier function and normal hair follicle morphology into adulthood (PubMed:11714727). {ECO:0000269|PubMed:11714727}.
uniprot
proteins
mass_dalton
98938
uniprot
proteins
pubmed
11714727
uniprot
proteins
pubmed
16170054
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
38395410
uniprot
proteins
pubmed
8823356
uniprot
proteins
sequence_length
886
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q08554}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, desmosome {ECO:0000269|PubMed:11714727, ECO:0000269|PubMed:38395410}.
uniprot
proteins
transmembrane_region
TRANSMEM 692..714; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins