Baz1b
entrez
22385
canonical
uniprot
Q9Z277
canonical
ensembl
ENSMUSG00000002748
resolver
ensp
ENSMUSP00000002825
resolver
genesymbol
Baz1b
resolver
genesymbol_syn
Wbscr9
resolver
genesymbol_syn
Wstf
resolver
uniprot
B9EJ99
resolver
uniprot
Q3URP5
resolver
uniprot
Q3USR7
resolver
uniprot
Q3UVM2
resolver
uniprot
Q8CAU9
resolver
uniprot
Q9CU68
resolver
uniprot_entry
BAZ1B_MOUSE
resolver
uniprot_sec
B9EJ99
resolver
uniprot_sec
Q3URP5
resolver
uniprot_sec
Q3USR7
resolver
uniprot_sec
Q3UVM2
resolver
uniprot_sec
Q8CAU9
resolver
uniprot_sec
Q9CU68
resolver
amino_acid_sequence
MAPLLGRKPFPLVKPLPGEEPLFTIPHTQEAFRTREEYEARLERYSERIWTCKSTGSSQLTHKEAWEEEQEVAELLKEEFPNWYEKLVLEMVHHNTASLEKLVDSAWLEIMTKYAVGEECDFEVGKEKMLKVKIVKIHPLEKVDEEAVEKKSDGACDSPSSDKENSSQMAQDLQKKETVVKEDEGRRESINDRARRSPRKLPTSLKKGERKWAPPKFLPHKYDVKLQNEDKIISNVPADSLIRTERPPNKEILRYFIRHNALRAGTGENAPWVVEDELVKKYSLPSKFSDFLLDPYKYMTLNPSTKRRNTGSPDRKPSKKPKRDSSSLSSPLNPKLWCHVHLEKSLNGPPLKVKNSKNSKSPEEHLEGVMKIMSPNNNKLHSFHIPKKGPAAKKPGKHSDKPLKAKGRGKGILNGQKSTGNSKSPSKCVKTPKTKMKQMTLLDMAKGTQKMTRTPRSSGGVPRSSGKPHKHLPPAALHLIAYYKENKDKEDKKSALSCVISKTARLLSNEDRARLPEELRALVQKRYELLEHKKRWASMSEEQRKEYLKKKRQELKERLREKAKERREREMLERLEKQKRFEDQELGGRNLPAFRLVDTPEGLPNTLFGDVALVVEFLSCYSGLLLPDAQYPITAVSLMEALSADKGGFLYLNRVLVILLQTLLQDEIAEDYGELGMKLSEIPLTLHSVSELVRLCLRRCDVQEDSEGSETDDNKDSTPFEDNEVQDEFLEKLETSEFFELTSEEKLRILTALCHRILMTYSVQDHMETRQQVSAELWKERLAVLKEENDKKRAEKQKRKEMEARNKENGKEENVLGKVDRKKEIVKIEQQVEVEADDMISAVKSRRLLSMQAKRKREIQERETKVRLEREAEEERMRKHKAAAEKAFQEGIAKAKLVLRRTPIGTDRNHNRYWLFSNEVPGLFIEKGWVHNSIDYRFKHHRKDHSNLPDDDYCPRSKKANLGKNASVNAHHGPALEAVETTVPKQGQNLWFLCDSQKELDELLSCLHPQGIRESQLKERLEKRYQEITHSIYLARKPNLGLKSCDGNQELLNFLRSDLIEVATRLQKGGLGYMEGTSEFEARVISLEKLKDFGECVIALQASVIKKFLQGFMAPKQKKRKLQSEDSTKSEEVDEEKKMVEEAKVASALEKWKTAIREAQTFSRMHVLLGMLDACIKWDMSAENARCKVCRKKGEDDKLILCDECNKAFHLFCLRPALYEVPDGEWQCPACQPPTARRNSRGRNYTEESTSEGSEGDESGEEEEEEEEEEEEEEDYEVAGLRLRPRKTIRGKQSVIPAARPGRPPGKKSHPARRSRPKDDPEVDDLVLQTKRISRRQSLELQKCEDILHKLVKYRFSWPFREPVTRDEAEDYYDVIEHPMDFQTIQNKCSCGNYRSVQEFLTDMKQVFANAELYNCRGSHVLSCMEKTEQCLLALLQKHLPGHPYVRRKRRKFPDRLADDEGDSDSESVGQSRGRRQKK
uniprot
proteins
ec_number
2.7.10.2
uniprot
proteins
function
FUNCTION: Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator (By similarity). Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph) (PubMed:19092802). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress (PubMed:19092802). Regulatory subunit of the ATP-dependent WICH-1 and WICH-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair (PubMed:11980720). Both complexes regulate the spacing of nucleosomes along the chromatin and have the ability to slide mononucleosomes to the center of a DNA template (PubMed:16514417). The WICH-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the WICH-5 ISWI chromatin remodeling complex (By similarity). The WICH-5 ISWI chromatin remodeling complex regulates the transcription of various genes, has a role in RNA polymerase I transcription (PubMed:16514417). Within the B-WICH complex has a role in RNA polymerase III transcription (By similarity). Mediates the recruitment of the WICH-5 ISWI chromatin remodeling complex to replication foci during DNA replication (By similarity). {ECO:0000250|UniProtKB:Q9UIG0, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:16514417, ECO:0000269|PubMed:19092802}.
uniprot
proteins
mass_dalton
170651
uniprot
proteins
protein_family
BAZ1B subfamily
uniprot
proteins
protein_family
WAL family
uniprot
proteins
pubmed
11980720
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16514417
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19092802
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
9858827
uniprot
proteins
sequence_length
1479
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00063, ECO:0000255|PROSITE-ProRule:PRU00475}. Note=Accumulates in pericentromeric heterochromatin during replication. Targeted to replication foci throughout S phase via its association with PCNA (By similarity). Localizes to sites of DNA damage (By similarity). {ECO:0000250|UniProtKB:Q9UIG0}.
uniprot
proteins