Kcnj10
entrez
16513
canonical
uniprot
Q9JM63
canonical
ensembl
ENSMUSG00000044708
resolver
ensp
ENSMUSP00000054356
resolver
enst
ENSMUST00000056136
resolver
genesymbol
Kcnj10
resolver
uniprot
Q56VN0
resolver
uniprot
Q8C7Z5
resolver
uniprot_entry
KCJ10_MOUSE
resolver
uniprot_entry
Q56VN0_MOUSE
resolver
uniprot_entry
Q8C7Z5_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Channel activity is strongly regulated by variations of cytosolic pH; channels are activated by alkaline and inhibited by acidic pH values. Activated by phosphatidylinositol 4,5 biphosphate (PtdIns(4,5)P2). Inhibited by Ba(2+) and Cs(+). {ECO:0000250|UniProtKB:P49655}.
uniprot
proteins
amino_acid_sequence
MTSVAKVYYSQTTQTESRPLVAPGIRRRRVLTKDGRSNVRMEHIADKRFLYLKDLWTTFIDMQWRYKLLLFSATFAGTWFLFGVVWYLVAVAHGDLLELGPPANHTPCVVQVHTLTGAFLFSLESQTTIGYGFRYISEECPLAIVLLIAQLVLTTILEIFITGTFLAKIARPKKRAETIRFSQHAVVASHNGKPCLMIRVANMRKSLLIGCQVTGKLLQTHQTKEGENIRLNQVNVTFQVDTASDSPFLILPLTFYHVVDETSPLKDLPLRSGEGDFELVLILSGTVESTSATCQVRTSYLPEEILWGYEFTPAISLSASGKYIADFSLFDQVVKVASPSGLRDSTVRYGDPEKLKLEESLREQAEKEGSALSVRISNV
uniprot
proteins
function
FUNCTION: May be responsible for potassium buffering action of glial cells in the brain (By similarity). Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium (By similarity). In the kidney, together with KCNJ16, mediates basolateral K(+) recycling in distal tubules; this process is critical for Na(+) reabsorption at the tubules (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P49655, ECO:0000250|UniProtKB:P78508}.
uniprot
proteins
mass_dalton
42432
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ10 subfamily
uniprot
proteins
pubmed
11169792
uniprot
proteins
pubmed
19420365
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
33811157
uniprot
proteins
pubmed
9647694
uniprot
proteins
sequence_length
379
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P78508}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P78508}. Basolateral cell membrane {ECO:0000250|UniProtKB:P78508}. Note=In kidney distal convoluted tubules, located in the basolateral membrane where it colocalizes with KCNJ16 (PubMed:33811157). {ECO:0000250|UniProtKB:P78508, ECO:0000269|PubMed:33811157}.
uniprot
proteins
transmembrane_region
TRANSMEM 62..88; /note="Helical; Name=M1"; /evidence="ECO:0000250|UniProtKB:P49655"; TRANSMEM 141..166; /note="Helical; Name=M2"; /evidence="ECO:0000250|UniProtKB:P49655
uniprot
proteins