Ido1
entrez
15930
canonical
uniprot
P28776
canonical
ensembl
ENSMUSG00000031551
resolver
ensp
ENSMUSP00000033956
resolver
ensp
ENSMUSP00000106295
resolver
enst
ENSMUST00000033956
resolver
enst
ENSMUST00000110667
resolver
genesymbol
Ido1
resolver
genesymbol_syn
Ido
resolver
genesymbol_syn
Indo
resolver
uniprot
D3YXV1
resolver
uniprot_entry
D3YXV1_MOUSE
resolver
uniprot_entry
I23O1_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Activity is inhibited by and MTH-trp (methylthiohydantoin-DL-tryptophan), modestly inhibited by L-1MT (1-methyl-L-tryptophan) but not D-1MT (1-methyl-D-tryptophan). {ECO:0000250|UniProtKB:P14902}.
uniprot
proteins
amino_acid_sequence
MALSKISPTEGSRRILEDHHIDEDVGFALPHPLVELPDAYSPWVLVARNLPVLIENGQLREEVEKLPTLSTDGLRGHRLQRLAHLALGYITMAYVWNRGDDDVRKVLPRNIAVPYCELSEKLGLPPILSYADCVLANWKKKDPNGPMTYENMDILFSFPGGDCDKGFFLVSLLVEIAASPAIKAIPTVSSAVERQDLKALEKALHDIATSLEKAKEIFKRMRDFVDPDTFFHVLRIYLSGWKCSSKLPEGLLYEGVWDTPKMFSGGSAGQSSIFQSLDVLLGIKHEAGKESPAEFLQEMREYMPPAHRNFLFFLESAPPVREFVISRHNEDLTKAYNECVNGLVSVRKFHLAIVDTYIMKPSKKKPTDGDKSEEPSNVESRGTGGTNPMTFLRSVKDTTEKALLSWP
uniprot
proteins
ec_number
1.13.11.52
uniprot
proteins
function
FUNCTION: Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway. Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses. Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells. Acts as a suppressor of anti-tumor immunity (PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan. Protects the fetus from maternal immune rejection (PubMed:15063630). {ECO:0000250|UniProtKB:P14902, ECO:0000269|PubMed:15063630, ECO:0000303|PubMed:25691885}.
uniprot
proteins
mass_dalton
45641
uniprot
proteins
protein_family
3-dioxygenase family
uniprot
proteins
protein_family
Indoleamine 2
uniprot
proteins
pubmed
15063630
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18026683
uniprot
proteins
pubmed
18384884
uniprot
proteins
pubmed
1937018
uniprot
proteins
pubmed
19741271
uniprot
proteins
pubmed
22157149
uniprot
proteins
pubmed
25691885
uniprot
proteins
sequence_length
407
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:19741271}.
uniprot
proteins