Tmem43
entrez
362401
canonical
uniprot
Q5XIP9
canonical
ensembl
ENSRNOG00000007519
resolver
ensembl
ENSRNOG00055004349
resolver
ensembl
ENSRNOG00060027304
resolver
ensembl
ENSRNOG00065024642
resolver
ensp
ENSRNOP00000095865
resolver
ensp
ENSRNOP00055005196
resolver
ensp
ENSRNOP00060039608
resolver
ensp
ENSRNOP00065034724
resolver
enst
ENSRNOT00055006914
resolver
enst
ENSRNOT00060047611
resolver
enst
ENSRNOT00065042438
resolver
genesymbol
Tmem43
resolver
uniprot_entry
TMM43_RAT
resolver
amino_acid_sequence
MAANYSSTGSRKEHVKVTSDPQPGFLERLSETSGGMFVGLVTFLLSFYLIFTNEGRALKTANLLAEGLSLVVSPDSIHSVAPENEGRLVHIIGALRTSKLLSDPNYGVHLPAVKLRRHVEMYQWVETEESNEYTEDGQVKKETKYSYNTEWRSEIVSSKNFDREIGHKNPSAMAVESFTATAPFVQIGRFFLSAGLIDKIDNFKPLSLAKLEDPHVDIIRRGDFFYHSENPKYPEVGDVRVSFSYAGLSSDDPDLGPAHVVTVIARQRGDQLIPYSTKSGDTLLLLHHGDFSAEEVFRREQKSNSMKTWGLRAAGWMAMFMGLNLMTRILYTLVDWFPVFRDLVNIGLKAFAFCVATSLTLLTVAAGWLFYRPLWAALLGCLALVPIIIARTRVPTKKLE
uniprot
proteins
function
FUNCTION: May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane (By similarity). Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 (By similarity). In addition, functions as a critical signaling component in mediating NF-kappa-B activation by acting downstream of EGFR and upstream of CARD10 (By similarity). Contributes to passive conductance current in cochlear glia-like supporting cells, mediated by gap junctions and necessary for hearing (By similarity). {ECO:0000250|UniProtKB:Q9BTV4}.
uniprot
proteins
mass_dalton
44774
uniprot
proteins
protein_family
TMEM43 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
400
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9BTV4}. Nucleus inner membrane {ECO:0000250|UniProtKB:Q9BTV4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9BTV4}. Cell membrane {ECO:0000250|UniProtKB:Q9BTV4}. Note=Retained in the inner nuclear membrane through interaction with EMD and A- and B-lamins. The N- and C-termini are oriented towards the nucleoplasm. The majority of the hydrophilic domain resides in the endoplasmic reticulum lumen (By similarity). {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..52; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 314..334; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 346..366; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 369..389; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins