Rtn4rl1
entrez
303311
canonical
uniprot
Q80WD0
canonical
ensembl
ENSRNOG00000003121
resolver
ensembl
ENSRNOG00055027355
resolver
ensembl
ENSRNOG00060030317
resolver
ensembl
ENSRNOG00065021186
resolver
ensp
ENSRNOP00000058866
resolver
ensp
ENSRNOP00000088543
resolver
ensp
ENSRNOP00000089829
resolver
ensp
ENSRNOP00000099059
resolver
ensp
ENSRNOP00000099591
resolver
ensp
ENSRNOP00000101203
resolver
ensp
ENSRNOP00000103900
resolver
ensp
ENSRNOP00000109379
resolver
ensp
ENSRNOP00000112050
resolver
enst
ENSRNOT00000095511
resolver
enst
ENSRNOT00000110559
resolver
enst
ENSRNOT00000122313
resolver
enst
ENSRNOT00000123607
resolver
enst
ENSRNOT00000132062
resolver
enst
ENSRNOT00000148928
resolver
enst
ENSRNOT00000149380
resolver
enst
ENSRNOT00000158282
resolver
genesymbol
Rtn4rl1
resolver
genesymbol_syn
Ngrh2
resolver
uniprot
A0A8I6A6E3
resolver
uniprot
A1L1I9
resolver
uniprot
Q7TQ96
resolver
uniprot_entry
A0A8I6A6E3_RAT
resolver
uniprot_entry
R4RL1_RAT
resolver
uniprot_sec
A1L1I9
resolver
uniprot_sec
Q7TQ96
resolver
amino_acid_sequence
MLRKGCCVELLLLLLAGELPLSGGCPRDCVCYPSPMTVSCQAHNFAAIPEGIPEDSERIFLQNNHITFLQQGHFSPAMVTLWIYSNNITFIAPNTFEGFVHLEELDLGDNRQLRTLAPETFQGLVKLHALYLYKCGLSSLPAGIFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWSLGQGIFRGLVNLDRLLLHENQLQWVHHKAFHDLHRLTTLFLFNNSLTELQGDCLAPLVALEFLRLNGNAWDCGCRARSLWEWLRRFRGSSSVVPCATPELRQGQDLKSLRVEDFRNCTGPASPHQIKSHTLSTSDRAARKEHHPSHGASRDKGHPHGHLPGSRSGSKKPGKNCTSHRNRNQISKGSAGKELPELQDYAPDYQHKFSFDIMPTARPKRKGKCARRTPIRAPSGVQQASSGTALGVSLLAWILGLVVSLR
uniprot
proteins
function
FUNCTION: Cell surface receptor. Plays a functionally redundant role in postnatal brain development and in regulating axon regeneration in the adult central nervous system. Contributes to normal axon migration across the brain midline and normal formation of the corpus callosum. Protects motoneurons against apoptosis; protection against apoptosis is probably mediated by MAG. Plays a role in inhibiting neurite outgrowth and axon regeneration via its binding to neuronal chondroitin sulfate proteoglycans. Binds heparin (By similarity). Like other family members, plays a role in restricting the number dendritic spines and the number of synapses that are formed during brain development (PubMed:22325200). Signaling mediates activation of Rho and downstream reorganization of the actin cytoskeleton (PubMed:22325200). {ECO:0000250|UniProtKB:Q8K0S5, ECO:0000269|PubMed:22325200}.
uniprot
proteins
mass_dalton
49775
uniprot
proteins
protein_family
Nogo receptor family
uniprot
proteins
pubmed
12694398
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15673660
uniprot
proteins
pubmed
22325200
uniprot
proteins
sequence_length
445
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15673660}; Lipid-anchor, GPI-anchor {ECO:0000305}. Membrane raft {ECO:0000250|UniProtKB:Q86UN2}. Perikaryon {ECO:0000269|PubMed:12694398, ECO:0000269|PubMed:15673660}. Cell projection {ECO:0000269|PubMed:15673660}. Note=Localized to the surface of neurons, including axons. {ECO:0000269|PubMed:12694398, ECO:0000269|PubMed:15673660}.
uniprot
proteins
transmembrane_region
TRANSMEM 424..444; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins