RHOT1
entrez
55288
canonical
uniprot
Q8IXI2
canonical
ensembl
ENSG00000126858
resolver
ensp
ENSP00000334724
resolver
ensp
ENSP00000346215
resolver
ensp
ENSP00000351132
resolver
ensp
ENSP00000378184
resolver
ensp
ENSP00000439737
resolver
ensp
ENSP00000654110
resolver
ensp
ENSP00000790415
resolver
enst
ENST00000354266
resolver
genesymbol
RHOT1
resolver
genesymbol_syn
ARHT1
resolver
hgnc
HGNC:21168
resolver
uniprot
A4FVB6
resolver
uniprot
A6NFV0
resolver
uniprot
B4DG48
resolver
uniprot
H7BXZ6
resolver
uniprot
J9JIH9
resolver
uniprot
Q6NUR3
resolver
uniprot
Q6P9F8
resolver
uniprot
Q6PJG1
resolver
uniprot
Q6YMW8
resolver
uniprot
Q86UB0
resolver
uniprot
Q8IW28
resolver
uniprot
Q8IXJ7
resolver
uniprot
Q9H067
resolver
uniprot
Q9H9N8
resolver
uniprot
Q9NUZ2
resolver
uniprot_entry
H7BXZ6_HUMAN
resolver
uniprot_entry
MIRO1_HUMAN
resolver
uniprot_sec
A4FVB6
resolver
uniprot_sec
A6NFV0
resolver
uniprot_sec
B4DG48
resolver
uniprot_sec
J9JIH9
resolver
uniprot_sec
Q6NUR3
resolver
uniprot_sec
Q6P9F8
resolver
uniprot_sec
Q6PJG1
resolver
uniprot_sec
Q6YMW8
resolver
uniprot_sec
Q86UB0
resolver
uniprot_sec
Q8IW28
resolver
uniprot_sec
Q8IXJ7
resolver
uniprot_sec
Q9H067
resolver
uniprot_sec
Q9H9N8
resolver
uniprot_sec
Q9NUZ2
resolver
amino_acid_sequence
MKKDVRILLVGEPRVGKTSLIMSLVSEEFPEEVPPRAEEITIPADVTPERVPTHIVDYSEAEQSDEQLHQEISQANVICIVYAVNNKHSIDKVTSRWIPLINERTDKDSRLPLILVGNKSDLVEYSSMETILPIMNQYTEIETCVECSAKNLKNISELFYYAQKAVLHPTGPLYCPEEKEMKPACIKALTRIFKISDQDNDGTLNDAELNFFQRICFNTPLAPQALEDVKNVVRKHISDGVADSGLTLKGFLFLHTLFIQRGRHETTWTVLRRFGYDDDLDLTPEYLFPLLKIPPDCTTELNHHAYLFLQSTFDKHDLDRDCALSPDELKDLFKVFPYIPWGPDVNNTVCTNERGWITYQGFLSQWTLTTYLDVQRCLEYLGYLGYSILTEQESQASAVTVTRDKKIDLQKKQTQRNVFRCNVIGVKNCGKSGVLQALLGRNLMRQKKIREDHKSYYAINTVYVYGQEKYLLLHDISESEFLTEAEIICDVVCLVYDVSNPKSFEYCARIFKQHFMDSRIPCLIVAAKSDLHEVKQEYSISPTDFCRKHKMPPPQAFTCNTADAPSKDIFVKLTTMAMYPHVTQADLKSSTFWLRASFGATVFAVLGFAMYKALLKQR
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Atypical mitochondrial nucleoside-triphosphatase (NTPase) involved in mitochondrial trafficking (PubMed:12482879, PubMed:16630562, PubMed:22396657, PubMed:30513825). Probably involved in control of anterograde transport of mitochondria and their subcellular distribution (PubMed:12482879, PubMed:16630562, PubMed:22396657). Promotes mitochondrial fission during high calcium conditions (PubMed:27716788). Can hydrolyze GTP, ATP and UTP (PubMed:30513825). {ECO:0000269|PubMed:12482879, ECO:0000269|PubMed:16630562, ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:27716788, ECO:0000269|PubMed:30513825}.
uniprot
proteins
mass_dalton
70784
uniprot
proteins
mutagenesis
MUTAGEN 13; /note="P->V: Causes constitutive activation inducing an aggregation of the mitochondrial network."; /evidence="ECO:0000269|PubMed:12482879, ECO:0000269|PubMed:14521508, ECO:0000269|PubMed:16630562"; MUTAGEN 18; /note="T->N: Causes constitutive inactivation."; /evidence="ECO:0000269|PubMed:12482879, ECO:0000269|PubMed:16630562"; MUTAGEN 156; /note="S->A: No effect on PINK1-PRKN-mediated degradation."; /evidence="ECO:0000269|PubMed:22396657"; MUTAGEN 208; /note="E->K: Abolishes the formation of thread-like mitochondria."; /evidence="ECO:0000269|PubMed:16630562"; MUTAGEN 328; /note="E->K: Abolishes the formation of thread-like mitochondria."; /evidence="ECO:0000269|PubMed:16630562"; MUTAGEN 427; /note="K->V: No effect."; /evidence="ECO:0000269|PubMed:16630562"; MUTAGEN 432; /note="S->N: No effect."; /evidence="ECO:0000269|PubMed:16630562
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy (PubMed:22396657, PubMed:24896179, PubMed:27605430). Deubiquitinated by USP30 (PubMed:24896179). {ECO:0000269|PubMed:22396657, ECO:0000269|PubMed:24896179, ECO:0000269|PubMed:27605430}.; PTM: Acetylation on Lys-92 decreases sensitivity of mitochondrial transport to elevated Ca(2+) levels, increases mitochondrial transport and promotes axon growth. Deacetylated by HDAC6 which blocks mitochondrial transport and mediates axon growth inhibition. {ECO:0000250|UniProtKB:A1L1L6}.
uniprot
proteins
protein_family
Mitochondrial Rho GTPase family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12482879
uniprot
proteins
pubmed
12696059
uniprot
proteins
pubmed
14521508
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16630562
uniprot
proteins
pubmed
19528298
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22396657
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24896179
uniprot
proteins
pubmed
24995978
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27605430
uniprot
proteins
pubmed
27716788
uniprot
proteins
pubmed
30513825
uniprot
proteins
pubmed
33132189
uniprot
proteins
sequence_length
618
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:12482879, ECO:0000269|PubMed:19528298}; Single-pass type IV membrane protein {ECO:0000269|PubMed:12482879, ECO:0000269|PubMed:19528298}. Note=Colocalizes with MGARP and RHOT2 at the mitochondria.
uniprot
proteins
transmembrane_region
TRANSMEM 593..615; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins