Casp14
entrez
12365
canonical
uniprot
O89094
canonical
ensembl
ENSMUSG00000005355
resolver
ensp
ENSMUSP00000005488
resolver
genesymbol
Casp14
resolver
uniprot
Q542Q1
resolver
uniprot_entry
CASPE_MOUSE
resolver
uniprot_entry
Q542Q1_MOUSE
resolver
amino_acid_sequence
MESEMSDPQPLQEERYDMSGARLALTLCVTKAREGSEVDMEALERMFRYLKFESTMKRDPTAQQFLEELDEFQQTIDNWEEPVSCAFVVLMAHGEEGLLKGEDEKMVRLEDLFEVLNNKNCKALRGKPKVYIIQACRGEHRDPGEELRGNEELGGDEELGGDEVAVLKNNPQSIPTYTDTLHIYSTVEGYLSYRHDEKGSGFIQTLTDVFIHKKGSILELTEEITRLMANTEVMQEGKPRKVNPEVQSTLRKKLYLQ
uniprot
proteins
ec_number
3.4.22.-
uniprot
proteins
function
FUNCTION: Non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and is required for cornification (PubMed:18156206). Regulates maturation of the epidermis by proteolytically processing filaggrin (PubMed:21654840). In vitro is equally active on the synthetic caspase substrates WEHD-ACF and IETD-AFC. Involved in processing of prosaposin in the epidermis (PubMed:24872419). May be involved in retinal pigment epithelium cell barrier function (By similarity). {ECO:0000250|UniProtKB:P31944, ECO:0000269|PubMed:11175259, ECO:0000269|PubMed:17515931, ECO:0000269|PubMed:18156206, ECO:0000269|PubMed:21654840, ECO:0000269|PubMed:24872419}.
uniprot
proteins
mass_dalton
29458
uniprot
proteins
mutagenesis
MUTAGEN 136; /note="C->A: Decrease in death-inducing activity."; /evidence="ECO:0000269|PubMed:9792675
uniprot
proteins
post_translational_modification
PTM: Maturation by proteolytic processing appears to be a two-step process. The precursor is processed by KLK7 to yield the p20/p8 intermediate form which acts the precursor to yield the p17/p10 mature form (By similarity). Initially it was reported that cleavage by granzyme B, caspase-8 and -10 generates the two active subunits, however the physiological relevance has not been established (PubMed:9823333). {ECO:0000250|UniProtKB:P31944, ECO:0000305|PubMed:9823333}.
uniprot
proteins
protein_family
Peptidase C14A family
uniprot
proteins
pubmed
10203698
uniprot
proteins
pubmed
11175259
uniprot
proteins
pubmed
11526440
uniprot
proteins
pubmed
17515931
uniprot
proteins
pubmed
18156206
uniprot
proteins
pubmed
21654840
uniprot
proteins
pubmed
24872419
uniprot
proteins
pubmed
9792675
uniprot
proteins
pubmed
9823333
uniprot
proteins
sequence_length
257
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11175259}. Nucleus {ECO:0000269|PubMed:11175259}.
uniprot
proteins