Slc6a19
entrez
74338
canonical
uniprot
Q9D687
canonical
ensembl
ENSMUSG00000021565
resolver
ensp
ENSMUSP00000022048
resolver
enst
ENSMUST00000022048
resolver
genesymbol
Slc6a19
resolver
genesymbol_syn
B0at1
resolver
genesymbol_syn
Xt3
resolver
uniprot
Q3KN89
resolver
uniprot
Q3TRY2
resolver
uniprot_entry
Q3KN89_MOUSE
resolver
uniprot_entry
Q3TRY2_MOUSE
resolver
uniprot_entry
S6A19_MOUSE
resolver
amino_acid_sequence
MVRLVLPNPGLEERIPSLDELEVIEKEEAGSRPKWDNKAQYMLTCVGFCVGLGNVWRFPYLCQSHGGGAFMIPFLILLVFEGIPLLYLEFAIGQRLRKGSMGVWSSIHPALKGIGIASMFVSFMVGLYYNTIIAWVMWYFFNSFQEPLPWSECPLNQNQTGYVEECAKSSSVDYFWYRETLNISTSISDSGSIQWWILLCLTCAWSVLYVCIIRGIETTGKAVYITSTLPYVVLTIFLIRGLTLKGATNGIVFLFTPNITELSNPNTWLDAGAQVFYSFSLAFGGLISFSSYNSVHNNCEMDSVIVSVINGFTSVYAATVVYSIIGFRATERFDDCVNTNILTLINGFDLPEGNVTSENFEAYQQWCNATNPQAYAQLKFQTCDINSFLSEGVEGTGLAFIVFTEAITKMPVSPLWSVLFFIMLFCLGLSSMFGNMEGVVVPLQDLNITPKKWPKELLTGLICLGTYLIAFIFTLNSGQYWLSLLDSFAGSIPLLIIAFCEMFAVVYVYGVDRFNKDIEFMIGHKPNIFWQVTWRVVSPLIMLVIFLFFFVIEVNKTLMYSIWDPNYEEFPKSQKIPYPNWVYAVVVTVAGVPCLSIPCFAIYKFIRNCCQKSDDHHGLVNTLSTASVNGDLKN
uniprot
proteins
function
FUNCTION: Transporter that mediates resorption of neutral amino acids across the apical membrane of renal and intestinal epithelial cells (PubMed:15044460, PubMed:17167413, PubMed:18424768, PubMed:19185582, PubMed:26240152). This uptake is sodium-dependent and chloride-independent (PubMed:15044460, PubMed:18424768, PubMed:19185582, PubMed:21636576, PubMed:26240152). Requires CLTRN in kidney or ACE2 in intestine for cell surface expression and amino acid transporter activity (PubMed:17167413, PubMed:18424768, PubMed:19185582, PubMed:22677001). {ECO:0000269|PubMed:15044460, ECO:0000269|PubMed:17167413, ECO:0000269|PubMed:18424768, ECO:0000269|PubMed:19185582, ECO:0000269|PubMed:21636576, ECO:0000269|PubMed:22677001, ECO:0000269|PubMed:26240152}.
uniprot
proteins
mass_dalton
71367
uniprot
proteins
protein_family
SLC6A19 subfamily
uniprot
proteins
protein_family
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
uniprot
proteins
pubmed
15044460
uniprot
proteins
pubmed
15804236
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17167413
uniprot
proteins
pubmed
18424768
uniprot
proteins
pubmed
19185582
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21636576
uniprot
proteins
pubmed
22677001
uniprot
proteins
pubmed
26240152
uniprot
proteins
sequence_length
634
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18424768}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes in small intestine brush border membranes (at protein level). {ECO:0000269|PubMed:19185582}.
uniprot
proteins
transmembrane_region
TRANSMEM 42..62; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 68..88; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 120..140; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 193..213; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 222..242; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 269..289; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 305..325; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 414..434; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 457..477; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 488..508; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 532..552; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 582..602; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins