IFI44L
entrez
10964
canonical
uniprot
Q53G44
canonical
ensembl
ENSG00000137959
resolver
ensp
ENSP00000359787
resolver
ensp
ENSP00000504938
resolver
ensp
ENSP00000505974
resolver
ensp
ENSP00000506000
resolver
ensp
ENSP00000506096
resolver
ensp
ENSP00000506384
resolver
ensp
ENSP00000506722
resolver
ensp
ENSP00000539131
resolver
enst
ENST00000459784
resolver
enst
ENST00000679848
resolver
enst
ENST00000679998
resolver
enst
ENST00000680110
resolver
enst
ENST00000680295
resolver
enst
ENST00000681613
resolver
genesymbol
IFI44L
resolver
genesymbol_syn
C1orf29
resolver
hgnc
HGNC:17817
resolver
uniprot
A0A7P0TBR4
resolver
uniprot
B4E019
resolver
uniprot
Q86TE1
resolver
uniprot
Q96B64
resolver
uniprot
Q99984
resolver
uniprot_entry
A0A7P0TBR4_HUMAN
resolver
uniprot_entry
B4E019_HUMAN
resolver
uniprot_entry
IF44L_HUMAN
resolver
uniprot_sec
Q86TE1
resolver
uniprot_sec
Q96B64
resolver
uniprot_sec
Q99984
resolver
amino_acid_sequence
MEVTTRLTWNDENHLRKLLGNVSLSLLYKSSVHGGSIEDMVERCSRQGCTITMAYIDYNMIVAFMLGNYINLHESSTEPNDSLWFSLQKKNDTTEIETLLLNTAPKIIDEQLVCRLSKTDIFIICRDNKIYLDKMITRNLKLRFYGHRQYLECEVFRVEGIKDNLDDIKRIIKAREHRNRLLADIRDYRPYADLVSEIRILLVGPVGSGKSSFFNSVKSIFHGHVTGQAVVGSDITSITERYRIYSVKDGKNGKSLPFMLCDTMGLDGAEGAGLCMDDIPHILKGCMPDRYQFNSRKPITPEHSTFITSPSLKDRIHCVAYVLDINSIDNLYSKMLAKVKQVHKEVLNCGIAYVALLTKVDDCSEVLQDNFLNMSRSMTSQSRVMNVHKMLGIPISNILMVGNYASDLELDPMKDILILSALRQMLRAADDFLEDLPLEETGAIERALQPCI
uniprot
proteins
function
FUNCTION: Type I interferon-stimulated gene (ISG) that plays a critical role in antiviral and antibacterial activity (PubMed:34722780). During bacterial infection, promotes macrophage differentiation and facilitates inflammatory cytokine secretion (PubMed:34722780). Plays a role in the control of respiratory syncytial virus/RSV infection, reducing the ability of the virus to replicate (PubMed:32611756). Exhibits a low antiviral activity against hepatitis C virus (PubMed:21478870). Also acts as a feedback regulator of IFN responses by negatively regulating IKBKB and IKBKE kinase activities through interaction with FKBP5 (PubMed:31434731). {ECO:0000269|PubMed:21478870, ECO:0000269|PubMed:31434731, ECO:0000269|PubMed:32611756, ECO:0000269|PubMed:34722780}.
uniprot
proteins
mass_dalton
51322
uniprot
proteins
protein_family
IFI44 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21478870
uniprot
proteins
pubmed
31434731
uniprot
proteins
pubmed
32611756
uniprot
proteins
pubmed
34722780
uniprot
proteins
sequence_length
452
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
uniprot
proteins