Cbx1
entrez
12412
canonical
uniprot
P83917
canonical
ensembl
ENSMUSG00000018666
resolver
ensp
ENSMUSP00000078640
resolver
ensp
ENSMUSP00000091475
resolver
ensp
ENSMUSP00000266052
resolver
ensp
ENSMUSP00000266055
resolver
ensp
ENSMUSP00000266056
resolver
ensp
ENSMUSP00000266057
resolver
ensp
ENSMUSP00000266060
resolver
enst
ENSMUST00000079702
resolver
enst
ENSMUST00000093943
resolver
genesymbol
Cbx1
resolver
genesymbol_syn
Cbx
resolver
uniprot
F6TS40
resolver
uniprot
P23197
resolver
uniprot
Q9CYJ8
resolver
uniprot_entry
CBX1_MOUSE
resolver
uniprot_entry
F6TS40_MOUSE
resolver
uniprot_entry
Q9CYJ8_MOUSE
resolver
uniprot_sec
P23197
resolver
amino_acid_sequence
MGKKQNKKKVEEVLEEEEEEYVVEKVLDRRVVKGKVEYLLKWKGFSDEDNTWEPEENLDCPDLIAEFLQSQKTAHETDKSEGGKRKADSDSEDKGEESKPKKKKEESEKPRGFARGLEPERIIGATDSSGELMFLMKWKNSDEADLVPAKEANVKCPQVVISFYEERLTWHSYPSEDDDKKDDKN
uniprot
proteins
function
FUNCTION: Component of heterochromatin, which recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression (PubMed:11242053). Also recognizes and binds histone H1.4 methylated at 'Lys-26' (H1.4K26me) (By similarity). Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane (PubMed:11571267). {ECO:0000250|UniProtKB:P83916, ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:11571267}.
uniprot
proteins
mass_dalton
21418
uniprot
proteins
mutagenesis
MUTAGEN 23; /note="V->M: Abolishes interaction with SUV39H1."; /evidence="ECO:0000269|PubMed:11242053"; MUTAGEN 26; /note="V->R: Abolishes interaction with SUV39H1."; /evidence="ECO:0000269|PubMed:11242053"; MUTAGEN 161; /note="I->E: Abolishes homodimer formation."; /evidence="ECO:0000269|PubMed:10747027"; MUTAGEN 164; /note="Y->E: Abolishes homodimer formation."; /evidence="ECO:0000269|PubMed:10747027
uniprot
proteins
post_translational_modification
PTM: Not phosphorylated. {ECO:0000250}.; PTM: Ubiquitinated. {ECO:0000250|UniProtKB:P83916}.
uniprot
proteins
pubmed
10202156
uniprot
proteins
pubmed
10562550
uniprot
proteins
pubmed
10747027
uniprot
proteins
pubmed
11242053
uniprot
proteins
pubmed
11571267
uniprot
proteins
pubmed
11882902
uniprot
proteins
pubmed
14765118
uniprot
proteins
pubmed
15145825
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16537907
uniprot
proteins
pubmed
1708124
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8978696
uniprot
proteins
pubmed
9171360
uniprot
proteins
sequence_length
185
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P83916}. Note=Unassociated with chromosomes during mitosis. {ECO:0000250}.
uniprot
proteins