Inpp5k
entrez
19062
canonical
uniprot
Q8C5L6
canonical
ensembl
ENSMUSG00000006127
resolver
ensp
ENSMUSP00000006286
resolver
enst
ENSMUST00000006286
resolver
genesymbol
Inpp5k
resolver
genesymbol_syn
Pps
resolver
genesymbol_syn
Skip
resolver
uniprot
O09040
resolver
uniprot
Q5ND43
resolver
uniprot_entry
INP5K_MOUSE
resolver
uniprot_entry
Q5ND43_MOUSE
resolver
uniprot_sec
O09040
resolver
amino_acid_sequence
MQHGDRNTPGYREGIMSAVSLRRPSAPKGFALSVHVVTWNVASAAPTVDLSDLLQLNNQDLNLDIYIIGLQEMNFGIISLLSDAAFEDPWSSLFMDMLSPLNFVKISQVRMQGLLLLVFAKYQHLPYIQIISTKSTPTGLYGYWGNKGGVNVCLKLYGYYVSIINCHLPPHMYNNDQRLEHFDRILESLTFEGYDVPNILDHDLILWFGDMNFRIEDFGLLFVQESITRKYYKELWEKDQLFIAKKNDQLLREFQEGPLLFPPTYKFDRHSNNYDTSEKKRKPAWTDRILWRLKRQPSQASPLASSVPTSYFLLTLKNYVSHMAYSISDHKPVTGTFDLELNPLMSVPLITMMPEHLWTMENDMLISYTSTPEFLSSSWDWIGLYKVGMRHINDYVAYVWVGDNQVSYGNNPNQVYINISAIPDTEDQFLLCYYSNNLHSVVGISQPFKIPIRSFLREDTLYEPEPQI
uniprot
proteins
ec_number
3.1.3.36
uniprot
proteins
ec_number
3.1.3.56
uniprot
proteins
ec_number
3.1.3.86
uniprot
proteins
function
FUNCTION: Inositol 5-phosphatase which acts on inositol 1,4,5-trisphosphate, inositol 1,3,4,5-tetrakisphosphate, phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. Has 6-fold higher affinity for phosphatidylinositol 4,5-bisphosphate than for inositol 1,4,5-trisphosphate (By similarity). Negatively regulates assembly of the actin cytoskeleton. Controls insulin-dependent glucose uptake among inositol 3,4,5-trisphosphate phosphatases; therefore, is the specific regulator for insulin signaling in skeletal muscle (PubMed:22247557, PubMed:22751929). {ECO:0000250|UniProtKB:Q9BT40, ECO:0000269|PubMed:22247557, ECO:0000269|PubMed:22751929}.
uniprot
proteins
mass_dalton
54159
uniprot
proteins
protein_family
4
uniprot
proteins
protein_family
5-trisphosphate 5-phosphatase type II family
uniprot
proteins
protein_family
Inositol 1
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22247557
uniprot
proteins
pubmed
22751929
uniprot
proteins
pubmed
28190456
uniprot
proteins
pubmed
9182797
uniprot
proteins
sequence_length
468
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:22247557, ECO:0000269|PubMed:22751929}. Cytoplasm {ECO:0000250|UniProtKB:Q9BT40}. Note=Following stimulation with EGF, translocates to membrane ruffles. {ECO:0000250|UniProtKB:Q9BT40}.
uniprot
proteins