P31651
uniprot
P31651
canonical
amino_acid_sequence
MDRKVAVHEDGYPVVSWVPEEGEMMDQKGKDQVKDRGQWTNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYFIFFFSCGIPVFFLEVALGQYSSQGSVTAWRKICPLLQGIGMASVVIESYLNIYYIIILAWALFYLFSSFTWELPWTTCTNSWNTEHCVDFLNHSSARGVSSSENFTSPVMEFWERRVLGITSGIHDLGSLRWELALCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLIILLIRGVTLPGAYQGIVFYLKPDLLRLKDPQVWMDAGTQIFFSFAICQGCLTALGSYNKYHNNCYRDSIALCFLNSATSFVAGFVVFSILGFMSQEQGIPISEVAESGPGLAFIAFPKAVTMMPLSQLWSCLFFIMLLFLGLDSQFVCMECLVTASMDMFPQQLRKSGRRDVLILAISVLCYLMGLLLVTEGGMYIFQLFDYYASSGICLLFLSLFEVICIGWVYGADRFYDNVEDMIGYRPWPLVKISWLFLTPGLCLATFFFSLSKYTPLKYNNVYMYPSWGYSIGWLLAFSSMACVPLFIIITFLKTQGSFKKRLRRLITPDPSLPQPGRRPPQDGSSAQNCSSSPAKQELIAWEKETHL
uniprot
proteins
function
FUNCTION: Transporter that mediates cellular uptake of betaine and GABA in a sodium- and chloride-dependent process (By similarity). May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation (Probable). Probably also involved in renal and hepatic osmotic regulation (PubMed:22071246). {ECO:0000250|UniProtKB:P48065, ECO:0000305|PubMed:22071246}.
uniprot
proteins
mass_dalton
69614
uniprot
proteins
protein_family
SLC6A12 subfamily
uniprot
proteins
protein_family
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
uniprot
proteins
pubmed
1517200
uniprot
proteins
pubmed
22071246
uniprot
proteins
sequence_length
614
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:22071246}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:22071246}; Multi-pass membrane protein {ECO:0000255}. Note=In kidney, locates in basolateral membranes of renal medulla. In liver, locates in hepatocytes cell membrane. {ECO:0000269|PubMed:22071246}.
uniprot
proteins
transmembrane_region
TRANSMEM 45..65; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 73..92; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 117..137; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 211..229; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 238..255; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 291..308; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 320..341; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 374..393; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 423..441; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 458..478; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 499..518; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 538..556; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins