Arglu1
entrez
290912
canonical
uniprot
Q5BJT0
canonical
ensembl
ENSRNOG00000024142
resolver
ensembl
ENSRNOG00055015029
resolver
ensembl
ENSRNOG00060004138
resolver
ensembl
ENSRNOG00065002524
resolver
ensp
ENSRNOP00000054160
resolver
ensp
ENSRNOP00055020969
resolver
ensp
ENSRNOP00060005200
resolver
ensp
ENSRNOP00065002265
resolver
enst
ENSRNOT00000057347
resolver
enst
ENSRNOT00055025702
resolver
enst
ENSRNOT00060006903
resolver
enst
ENSRNOT00065003317
resolver
genesymbol
Arglu1
resolver
uniprot
A0JPJ8
resolver
uniprot_entry
ARGL1_RAT
resolver
uniprot_sec
A0JPJ8
resolver
amino_acid_sequence
MGRSRSRSSSRSKHTKSSKHNKKRSRSRSRSRDKERVRKRSKSRESKRNRRRESRSRSRSTNAAASRRERERASSPPDRIDIFGRTVSKRSSLDEKQKREEEEKKAEFERQRKIRQQEIEEKLIEEETARRVEELVAKRVEEELEKRKDEIEREVLRRVEEAKRIMEKQLLEELERQRQAELAAQKAREEEERAKREELERILEENNRKIAEAQAKLAEEQLRIVEEQRKIHEERMKLEQERQRQQKEEQKIILGKGKSRPKLSFSLKTQD
uniprot
proteins
function
FUNCTION: Dual function regulator of gene expression; regulator of transcription and modulator of alternative splicing. General coactivator of nuclear receptor-induced gene expression, including genes activated by the glucocorticoid receptor NR3C1. Binds to a subset of pre-mRNAs and to components of the spliceosome machinery to directly modulate basal alternative splicing; involved in simple and complex cassette exon splicing events (By similarity). Binds its own pre-mRNA and regulates its alternative splicing and degradation; one of the alternatively spliced products is a stable intronic sequence RNA (sisRNA) that binds the protein to regulate its ability to affect splicing (By similarity). Binding of the sisRNA stimulates phase separation and localization to nuclear speckles, which may contribute to activation of nuclear receptor-induced gene expression (By similarity). May also indirectly modulate alternative splicing (By similarity). Regulates transcription of genes involved in heart development, neuronal cell function, protein localization and chromatin localization. Regulates splicing of genes involved in neurogenesis and chromatin organization. Essential for central nervous system development (By similarity). Required for the estrogen-dependent expression of ESR1 target genes. Can act in cooperation with MED1 (By similarity). {ECO:0000250|UniProtKB:Q3UL36, ECO:0000250|UniProtKB:Q9NWB6}.
uniprot
proteins
mass_dalton
32887
uniprot
proteins
protein_family
ARGLU1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
271
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NWB6}. Nucleus speckle {ECO:0000250|UniProtKB:Q9NWB6}. Chromosome {ECO:0000250|UniProtKB:Q9NWB6}. Note=Recruited, in an estrogen-dependent manner, to ESR1 target gene promoters (By similarity). Colocalizes with MED1 in nuclear speckles (By similarity). Binding of sisRNA promotes phase separation and localization to nuclear speckles (By similarity). Associated with glucocorticoid response elements of target genes, even in the absence of glucocorticoid receptor ligands (By similarity). {ECO:0000250|UniProtKB:Q3UL36, ECO:0000250|UniProtKB:Q9NWB6}.
uniprot
proteins