Slc25a24
entrez
229731
canonical
uniprot
Q8BMD8
canonical
ensembl
ENSMUSG00000040322
resolver
ensp
ENSMUSP00000029477
resolver
enst
ENSMUST00000029477
resolver
genesymbol
Slc25a24
resolver
genesymbol_syn
Scamc1
resolver
uniprot
Q3TCQ2
resolver
uniprot
Q3THY3
resolver
uniprot
Q7TPC2
resolver
uniprot_entry
SCMC1_MOUSE
resolver
uniprot_sec
Q3TCQ2
resolver
uniprot_sec
Q3THY3
resolver
uniprot_sec
Q7TPC2
resolver
activity_regulation
ACTIVITY REGULATION: Activated by an increase in cytosolic calcium levels that induces a conformational change of the N-terminal regulatory domain, uncapping the channel and allowing transport. When calcium levels are high, the amphipathic alpha-helix of the linker region is bound to a cleft in the N-terminal regulatory domain, allowing substrate transport by the carrier domain. When calcium levels drop, the cleft closes and the amphipathic alpha-helix is released to bind to the carrier domain, inhibiting substrate transport. Inhibited by bathophenanthroline, mersalyl, p-hydroxymercuribenzoate, bromcresol purple and tannic acid. {ECO:0000250|UniProtKB:Q6NUK1}.
uniprot
proteins
amino_acid_sequence
MLRWLRAFVLPTAACHDAEPPTRYETLFRALDRNGDGVVDIGELQQGLQSLGIPLGQDAEEKIFTTGDVNKDGKLDFEEFMKYLKDHEKKMKLAFKSLDKNNDGKIEPSEIVQSLQMLGLHISEKQAELILQSIDSDGTMTVDWNEWRDYFLFNPVTDIEEIIRFWKHSTGIDIGDSLTIPDEFTEDEKKSGQWWRQLLAGGVAGAVSRTSTAPLDRLKVMMQVHGSKSMNIFGGFRQMVKEGGIRSLWRGNGTNVIKIAPETAVKFWAYEQYKKLLTEEGQKLGTFERFISGSMAGATAQTFIYPMEVLKTRLAVAKTGQYSGIYGCAKKILKHEGFGAFYKGYIPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLSCGALSSTCGQLASYPLALVRTRMQAQATVEGAPQLSMVGLFQRIVSKEGVSGLYRGITPNFMKVLPAVGISYVVYENMKQTLGVAQK
uniprot
proteins
function
FUNCTION: Electroneutral antiporter that mediates the transport of adenyl nucleotides through the inner mitochondrial membrane. Originally identified as an ATP-magnesium/inorganic phosphate antiporter, it also acts as a broad specificity adenyl nucleotide antiporter. By regulating the mitochondrial matrix adenyl nucleotide pool, could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways. In vitro, a low activity is also observed with guanyl and pyrimidine nucleotides. May play a role in protecting cells against oxidative stress-induced cell death, by buffering calcium levels in the mitochondrial matrix through the formation of calcium-phosphate precipitates. {ECO:0000250|UniProtKB:Q6NUK1}.
uniprot
proteins
mass_dalton
52902
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
15054102
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
475
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:15054102}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 198..215; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 251..270; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 294..307; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 344..363; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 387..404; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 444..463; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins