Fitm2
entrez
228859
canonical
uniprot
P59266
canonical
ensembl
ENSMUSG00000048486
resolver
ensp
ENSMUSP00000105045
resolver
enst
ENSMUST00000109418
resolver
genesymbol
Fitm2
resolver
genesymbol_syn
Fit2
resolver
uniprot
B9EHX3
resolver
uniprot
Q5BKP7
resolver
uniprot_entry
FITM2_MOUSE
resolver
uniprot_sec
B9EHX3
resolver
uniprot_sec
Q5BKP7
resolver
amino_acid_sequence
MEHLERCAWFLRGTLVRATVRRHLPWALVAAMLAGSVVKELSPLPESYLSNKRNVLNVYFVKLAWAWTVCLLLPFIALTNYHLTGKTSLVLRRLSTLLVGTAIWYICTALFSNIEHYTGSCYQSPALEGIRQEHRSKQQCHREGGFWHGFDISGHSFLLTFCALMIVEEMAVLHEVKTDRGHHLHAAITTLVVALGFLTFIWVWMFLCTAVYFHDLTQKVFGTMFGLLGWYGTYGYWYLKSFSPGLPPQSCSLTLKRDTYKK
uniprot
proteins
ec_number
3.6.1.-
uniprot
proteins
function
FUNCTION: Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates such as oleoyl-CoA/(9Z)-octadecenoyl-CoA and arachidonoyl-CoA/(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA in the endoplasmic reticulum (ER) lumen (By similarity). This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis (By similarity) (PubMed:18160536, PubMed:26504167). Directly binds to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis (By similarity) (PubMed:22106267). May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). {ECO:0000255|HAMAP-Rule:MF_03230, ECO:0000269|PubMed:18160536, ECO:0000269|PubMed:22106267, ECO:0000269|PubMed:26504167}.
uniprot
proteins
mass_dalton
30016
uniprot
proteins
mutagenesis
MUTAGEN 80; /note="N->A: Decreased specific binding to triglyceride. Decreased lipid droplet size. No change in protein expression levels and subcellular localization to the ER."; /evidence="ECO:0000269|PubMed:22106267
uniprot
proteins
protein_family
FIT family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18160536
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22106267
uniprot
proteins
pubmed
26504167
uniprot
proteins
pubmed
30923760
uniprot
proteins
sequence_length
262
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18160536, ECO:0000269|PubMed:22106267}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03230}.
uniprot
proteins
transmembrane_region
TRANSMEM 24..44; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 58..78; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 94..114; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 146..166; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 191..211; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 219..239; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins