BRAP
entrez
8315
canonical
uniprot
Q7Z569
canonical
ensembl
ENSG00000089234
resolver
ensp
ENSP00000330813
resolver
ensp
ENSP00000403524
resolver
ensp
ENSP00000541625
resolver
genesymbol
BRAP
resolver
genesymbol_syn
RNF52
resolver
hgnc
HGNC:1099
resolver
uniprot
B4DRM1
resolver
uniprot
B9EGS8
resolver
uniprot
O43238
resolver
uniprot
O75341
resolver
uniprot
Q59H81
resolver
uniprot_entry
BRAP_HUMAN
resolver
uniprot_entry
Q59H81_HUMAN
resolver
uniprot_sec
B4DRM1
resolver
uniprot_sec
B9EGS8
resolver
uniprot_sec
O43238
resolver
uniprot_sec
O75341
resolver
amino_acid_sequence
MSVSLVVIRLELAEHSPVPAGFGFSAAAGEMSDEEIKKTTLASAVACLEGKSPGEKVAIIHQHLGRREMTDVIIETMKSNPDELKTTVEERKSSEASPTAQRSKDHSKECINAAPDSPSKQLPDQISFFSGNPSVEIVHGIMHLYKTNKMTSLKEDVRRSAMLCILTVPAAMTSHDLMKFVAPFNEVIEQMKIIRDSTPNQYMVLIKFRAQADADSFYMTCNGRQFNSIEDDVCQLVYVERAEVLKSEDGASLPVMDLTELPKCTVCLERMDESVNGILTTLCNHSFHSQCLQRWDDTTCPVCRYCQTPEPVEENKCFECGVQENLWICLICGHIGCGRYVSRHAYKHFEETQHTYAMQLTNHRVWDYAGDNYVHRLVASKTDGKIVQYECEGDTCQEEKIDALQLEYSYLLTSQLESQRIYWENKIVRIEKDTAEEINNMKTKFKETIEKCDNLEHKLNDLLKEKQSVERKCTQLNTKVAKLTNELKEEQEMNKCLRANQVLLQNKLKEEERVLKETCDQKDLQITEIQEQLRDVMFYLETQQKINHLPAETRQEIQEGQINIAMASASSPASSGGSGKLPSRKGRSKRGK
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport. {ECO:0000269|PubMed:14724641, ECO:0000303|PubMed:10777491}.
uniprot
proteins
mass_dalton
67305
uniprot
proteins
mutagenesis
MUTAGEN 264; /note="C->A: Loss of E3 ubiquitin-protein ligase activity."; /evidence="ECO:0000269|PubMed:14724641
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
10508479
uniprot
proteins
pubmed
10777491
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14724641
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9497340
uniprot
proteins
sequence_length
592
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9497340}.
uniprot
proteins