COX7A2L
entrez
9167
canonical
uniprot
O14548
canonical
ensembl
ENSG00000115944
resolver
ensp
ENSP00000234301
resolver
ensp
ENSP00000367938
resolver
ensp
ENSP00000707206
resolver
enst
ENST00000234301
resolver
enst
ENST00000378669
resolver
genesymbol
COX7A2L
resolver
genesymbol_syn
COX7AR
resolver
genesymbol_syn
COX7RP
resolver
genesymbol_syn
SCAF1
resolver
genesymbol_syn
SCAFI
resolver
hgnc
HGNC:2289
resolver
uniprot
D6W5A1
resolver
uniprot
Q6FGA0
resolver
uniprot
Q9P118
resolver
uniprot_entry
CO72L_HUMAN
resolver
uniprot_entry
Q6FGA0_HUMAN
resolver
uniprot_sec
D6W5A1
resolver
uniprot_sec
Q9P118
resolver
amino_acid_sequence
MYYKFSGFTQKLAGAWASEAYSPQGLKPVVSTEAPPIIFATPTKLTSDSTVYDYAGKNKVPELQKFFQKADGVPVYLKRGLPDQMLYRTTMALTVGGTIYCLIALYMASQPKNK
uniprot
proteins
function
FUNCTION: Assembly factor that mediates the formation of some mitochondrial respiratory supercomplexes (respirasomes), thereby promoting oxidative phosphorylation and energy metabolism (PubMed:27545886, PubMed:30428348, PubMed:33727070, PubMed:36198313). Acts as a molecular adapter that associates with both mitochondrial respiratory complexes III (CIII) and IV (CIV), promoting their association (PubMed:27545886, PubMed:36198313). Mediates the formation of various mitochondrial respiratory supercomplexes, such as MCIII(2)IV(2), composed of two CIII and two CIV, and the CS-respirasome (MCI(1)III(2)IV(2)), composed of one CI, two CIII and two CIV (PubMed:27545886, PubMed:30428348). Not involved in the formation of the canonical respirasome (MCI(1)III(2)IV(1)), composed of one CI, two CIII and one CIV (By similarity). The formation of different respirasomes is important for cell adaptation to oxygen conditions and prevent metabolic exhaustion: supercomplexes mediated by COX7A2L/SCAF1 are required to maintain oxidative phosphorylation upon low oxygen conditions and promote metabolic rewiring toward glycolysis (PubMed:36198313). {ECO:0000250|UniProtKB:Q99KD6, ECO:0000269|PubMed:27545886, ECO:0000269|PubMed:30428348, ECO:0000269|PubMed:33727070, ECO:0000269|PubMed:36198313}.
uniprot
proteins
mass_dalton
12615
uniprot
proteins
mutagenesis
MUTAGEN 74..75; /note="Missing: Abolished ability to promote association between both mitochondrial respiratory complexes III (CIII) and IV (CIV)."; /evidence="ECO:0000269|PubMed:30428348
uniprot
proteins
protein_family
Cytochrome c oxidase VIIa family
uniprot
proteins
pubmed
10335655
uniprot
proteins
pubmed
11156535
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
27545886
uniprot
proteins
pubmed
30428348
uniprot
proteins
pubmed
31023583
uniprot
proteins
pubmed
33727070
uniprot
proteins
pubmed
36198313
uniprot
proteins
pubmed
36253618
uniprot
proteins
pubmed
9418891
uniprot
proteins
sequence_length
114
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:27545886}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q99KD6}.
uniprot
proteins
transmembrane_region
TRANSMEM 82..107; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q99KD6
uniprot
proteins