Kcnj14
entrez
211480
canonical
uniprot
Q8JZN3
canonical
ensembl
ENSMUSG00000058743
resolver
ensp
ENSMUSP00000071829
resolver
enst
ENSMUST00000071937
resolver
genesymbol
Kcnj14
resolver
genesymbol_syn
Irk4
resolver
uniprot
Q8BMK3
resolver
uniprot
Q8BXM0
resolver
uniprot_entry
KCJ14_MOUSE
resolver
uniprot_sec
Q8BMK3
resolver
uniprot_sec
Q8BXM0
resolver
activity_regulation
ACTIVITY REGULATION: Channel activity is regulated by variations of cytosolic pH; channels are activated by alkaline and inhibited by acidic pH values. Inhibited by Ba(2+) and Cs(+) in a voltage-dependent manner; sensitivity to those inhibitors is lower than in other Kir channels. {ECO:0000250|UniProtKB:Q9UNX9}.
uniprot
proteins
amino_acid_sequence
MGLARALRRLSGALEPGNSRAGDEEEAGAGLCRNGWAPGPVAGSRRRGRFVKKDGHCNVRFVNLGGQGARYLSDLFTTCVDVRWRWMCLLFSCSFLASWLLFGLTFWLIASLHGDLAAPPPPAPCFSQVASFLAAFLFALETQTSIGYGVRSVTEECPAAVAAVVLQCIAGCVLDAFVVGAVMAKMAKPKKRNETLVFSENAVVALRDHRLCLMWRVGNLRRSHLVEAHVRAQLLQPRVTPEGEYIPLDHQDVDVGFDGGTDRIFLVSPITIVHEIDSASPLYELGRAELARADFELVVILEGMVEATAMTTQCRSSYLPGELLWGHRFEPVLFQRGSQYEVDYRHFHRTYEVPGTPVCSAKELDERAEQASHSPKSSFPGSLTAFCYENELALSCCQEEDEEEDTKEGTSAETPERAASPQALTPTLALTLPP
uniprot
proteins
function
FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. {ECO:0000250|UniProtKB:Q9UNX9}.
uniprot
proteins
mass_dalton
47607
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ14 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
434
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 82..108; /note="Helical; Name=M1"; /evidence="ECO:0000250|UniProtKB:F1NHE9"; TRANSMEM 158..185; /note="Helical; Name=M2"; /evidence="ECO:0000250|UniProtKB:F1NHE9
uniprot
proteins