KCNAB3
entrez
9196
canonical
uniprot
O43448
canonical
ensembl
ENSG00000170049
resolver
ensp
ENSP00000302719
resolver
ensp
ENSP00000580663
resolver
ensp
ENSP00000580664
resolver
ensp
ENSP00000609172
resolver
enst
ENST00000303790
resolver
genesymbol
KCNAB3
resolver
genesymbol_syn
KCNA3B
resolver
hgnc
HGNC:6230
resolver
uniprot
Q4VAW0
resolver
uniprot_entry
KCAB3_HUMAN
resolver
uniprot_sec
Q4VAW0
resolver
amino_acid_sequence
MQVSIACTEQNLRSRSSEDRLCGPRPGPGGGNGGPAGGGHGNPPGGGGSGPKARAALVPRPPAPAGALRESTGRGTGMKYRNLGKSGLRVSCLGLGTWVTFGSQISDETAEDVLTVAYEHGVNLFDTAEVYAAGKAERTLGNILKSKGWRRSSYVITTKIFWGGQAETERGLSRKHIIEGLRGSLERLQLGYVDIVFANRSDPNCPMEEIVRAMTYVINQGLALYWGTSRWGAAEIMEAYSMARQFNLIPPVCEQAEHHLFQREKVEMQLPELYHKIGVGSVTWYPLACGLITSKYDGRVPDTCRASIKGYQWLKDKVQSEDGKKQQAKVMDLLPVAHQLGCTVAQLAIAWCLRSEGVSSVLLGVSSAEQLIEHLGALQVLSQLTPQTVMEIDGLLGNKPHSKK
uniprot
proteins
ec_number
1.1.1.-
uniprot
proteins
function
FUNCTION: Regulatory subunit of the voltage-gated potassium (Kv) channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunit (PubMed:9857044). The beta-3/KCNAB3 subunit may mediate closure of potassium channels (By similarity). Increases inactivation of Kv1.5/KCNA5 alpha subunit-containing channels (PubMed:9857044). May display nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity (By similarity). The binding of oxidized and reduced NADP(H) cofactors may be required for the regulation of potassium channel activity (By similarity). {ECO:0000250|UniProtKB:P62483, ECO:0000250|UniProtKB:P63144, ECO:0000269|PubMed:9857044}.
uniprot
proteins
mass_dalton
43670
uniprot
proteins
protein_family
Shaker potassium channel beta subunit family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9857044
uniprot
proteins
sequence_length
404
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q14722}.
uniprot
proteins