Oprk1
entrez
29335
canonical
uniprot
P34975
canonical
ensembl
ENSRNOG00000007647
resolver
ensembl
ENSRNOG00055017680
resolver
ensembl
ENSRNOG00060009622
resolver
ensembl
ENSRNOG00065018294
resolver
ensp
ENSRNOP00000010255
resolver
ensp
ENSRNOP00055024030
resolver
ensp
ENSRNOP00060012690
resolver
ensp
ENSRNOP00065024397
resolver
enst
ENSRNOT00000010254
resolver
enst
ENSRNOT00055029914
resolver
enst
ENSRNOT00060016244
resolver
enst
ENSRNOT00065030660
resolver
genesymbol
Oprk1
resolver
genesymbol_syn
Ror-d
resolver
uniprot_entry
OPRK_RAT
resolver
amino_acid_sequence
MESPIQIFRGEPGPTCAPSACLLPNSSSWFPNWAESDSNGSVGSEDQQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSAVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLASSVGISAIVLGGTKVREDVDVIECSLQFPDDEYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITKLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAVLSSYYFCIALGYTNSSLNPVLYAFLDENFKRCFRDFCFPIKMRMERQSTNRVRNTVQDPASMRDVGGMNKPV
uniprot
proteins
function
FUNCTION: G protein-coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. {ECO:0000269|PubMed:20358363, ECO:0000269|PubMed:8240267}.
uniprot
proteins
mass_dalton
42688
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
20358363
uniprot
proteins
pubmed
7896774
uniprot
proteins
pubmed
8103466
uniprot
proteins
pubmed
8234341
uniprot
proteins
pubmed
8240267
uniprot
proteins
pubmed
8240268
uniprot
proteins
pubmed
8396539
uniprot
proteins
sequence_length
380
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8240267}; Multi-pass membrane protein {ECO:0000269|PubMed:8240267}.
uniprot
proteins
transmembrane_region
TRANSMEM 58..85; /note="Helical; Name=1"; /evidence="ECO:0000250"; TRANSMEM 96..119; /note="Helical; Name=2"; /evidence="ECO:0000250"; TRANSMEM 133..154; /note="Helical; Name=3"; /evidence="ECO:0000250"; TRANSMEM 174..196; /note="Helical; Name=4"; /evidence="ECO:0000250"; TRANSMEM 223..247; /note="Helical; Name=5"; /evidence="ECO:0000250"; TRANSMEM 275..296; /note="Helical; Name=6"; /evidence="ECO:0000250"; TRANSMEM 312..333; /note="Helical; Name=7"; /evidence="ECO:0000250
uniprot
proteins