Lck
entrez
313050
canonical
uniprot
Q01621
canonical
ensembl
ENSRNOG00000009705
resolver
ensp
ENSRNOP00000012936
resolver
ensp
ENSRNOP00000111801
resolver
enst
ENSRNOT00000012936
resolver
enst
ENSRNOT00000145835
resolver
genesymbol
Lck
resolver
uniprot
A0A0H2UHH7
resolver
uniprot
B1H265
resolver
uniprot_entry
A0A0H2UHH7_RAT
resolver
uniprot_entry
LCK_RAT
resolver
uniprot_sec
B1H265
resolver
activity_regulation
ACTIVITY REGULATION: The relative activities of the inhibitory tyrosine-protein kinase CSK and the activating tyrosine-protein phosphatase PTPRC/CD45 determine the level of LCK activity. These interactions allow rapid and efficient activation of LCK in response to TCR stimulation (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MGCVCSSNPEDDWMENIDVCENCHYPIVPLDSKSTLPIRTGSEVRDPLVTYEGSLPPASPLQDNLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHDLVRHYTNASDGLCTKLSRPCQTQKPQKPWWEDEWEVPRETLKLVERLGAGQFGEVWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHPRLVRLYAVVTQEPIYIITEYMENGSLVDFLKTPSGIKLNVNKLLDMAAQIAEGMAFIEEQNYIHRDLRAANILVSDTLSCKIADFGLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPEVIQNLEKGYRMVRPDNCPEELYHLMMLCWKERPEDRPTFDYLRSVLDDFFTATEGQYQPQP
uniprot
proteins
disease_involvement
DISEASE: Note=Proviral insertion upstream of the Lck gene causes overexpression, leading to the development of thymic lymphoma.
uniprot
proteins
ec_number
2.7.10.2
uniprot
proteins
function
FUNCTION: Non-receptor tyrosine-protein kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T-cell antigen receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK protein to the vicinity of the TCR-CD3 complex. LCK then phosphorylates tyrosine residues within the immunoreceptor tyrosine-based activation motifs (ITAM) of the cytoplasmic tails of the TCR-gamma chains and CD3 subunits, initiating the TCR-CD3 signaling pathway. Once stimulated, the TCR recruits the tyrosine kinase ZAP70, that becomes phosphorylated and activated by LCK. Following this, a large number of signaling molecules are recruited, ultimately leading to lymphokine production. LCK also contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, which leads to hyperphosphorylation and activation of LCK. Also plays a role in the IL2 receptor-linked signaling pathway that controls the T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2, the microtubule-associated protein MAPT, RHOH or TYROBP (By similarity). Interacts with UNC119; this interaction plays a crucial role in activation of LCK (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
57890
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated on Tyr-394, increasing enzymatic activity, this site is dephosphorylated by PTN22. Phosphorylated on Tyr-505 by CSK, decreasing activity. Dephosphorylated by PTPRC/CD45. Dephosphorylation at Tyr-394 by PTPN2 negatively regulates T-cells differentiation (By similarity). Dephosphorylation at Tyr-394 by DUSP22 negatively regulates T-cell receptor signaling (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P06239}.; PTM: Myristoylation is required prior to palmitoylation. {ECO:0000250}.; PTM: Palmitoylation regulates association with the plasma membrane and could be mediated by ZDHHC2. {ECO:0000250|UniProtKB:P06239}.; PTM: 'Lys-63'-linked ubiquitinated at Lys-99 and Lys-276 by UBR2; this modification is required for autophosphorylation at Tyr-394. {ECO:0000250|UniProtKB:P06239}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
SRC subfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8423992
uniprot
proteins
sequence_length
509
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P06239}; Lipid-anchor {ECO:0000250|UniProtKB:P06239}; Cytoplasmic side {ECO:0000250|UniProtKB:P06239}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P06239}. Note=Present in lipid rafts in an inactive form. {ECO:0000250|UniProtKB:P06239}.
uniprot
proteins