Csnk2a2
entrez
13000
canonical
uniprot
O54833
canonical
ensembl
ENSMUSG00000046707
resolver
ensp
ENSMUSP00000055919
resolver
ensp
ENSMUSP00000148404
resolver
ensp
ENSMUSP00000148660
resolver
enst
ENSMUST00000056919
resolver
enst
ENSMUST00000212214
resolver
genesymbol
Csnk2a2
resolver
uniprot
Q545V8
resolver
uniprot
Q8CDH5
resolver
uniprot_entry
CSK22_MOUSE
resolver
uniprot_entry
Q545V8_MOUSE
resolver
uniprot_entry
Q8CDH5_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Constitutively active protein kinase whose activity is not directly affected by phosphorylation. Seems to be regulated by level of expression and localization (By similarity). {ECO:0000250|UniProtKB:P19784}.
uniprot
proteins
amino_acid_sequence
MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGQDNYDQLVRIAKVLGTDELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCAENTVLSSGLTAAR
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Phosphorylates a number of DNA repair proteins in response to DNA damage, such as MDC1, RAD9A, RAD51 and HTATSF1, promoting their recruitment to DNA damage sites. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. May phosphorylate histone H2A on 'Ser-1'. {ECO:0000250|UniProtKB:P19784}.
uniprot
proteins
mass_dalton
41215
uniprot
proteins
protein_family
CK2 subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Ser/Thr protein kinase family
uniprot
proteins
pubmed
10471512
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19273531
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28355567
uniprot
proteins
pubmed
9503019
uniprot
proteins
pubmed
9694889
uniprot
proteins
sequence_length
350
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28355567}. Cytoplasm {ECO:0000269|PubMed:28355567}. Note=Interaction with SIRT6 prevents translocation into the nucleus. {ECO:0000269|PubMed:28355567}.
uniprot
proteins