TACR1
entrez
6869
canonical
uniprot
P25103
canonical
ensembl
ENSG00000115353
resolver
ensp
ENSP00000303522
resolver
ensp
ENSP00000386448
resolver
genesymbol
TACR1
resolver
genesymbol_syn
NK1R
resolver
genesymbol_syn
TAC1R
resolver
hgnc
HGNC:11526
resolver
uniprot
A8K150
resolver
uniprot_entry
NK1R_HUMAN
resolver
uniprot_sec
A8K150
resolver
amino_acid_sequence
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
uniprot
proteins
function
FUNCTION: Receptor for the tachykinin substance P, also able to bind and respond to tachynins neurokinin A/substance K and neurokinin B/neuromedin-K (PubMed:1718267, PubMed:15452552). The rank order of affinity of this receptor to tachykinins is: substance P > neurokinin A/substance K > neurokinin B/neuromedin-K (PubMed:1718267). Substance P binding to its receptor triggers G protein-coupled receptor signaling via activation of phosphatidylinositol hydrolysis by phospholipase C. Substance P binding also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP) (By similarity). {ECO:0000250|UniProtKB:P14600, ECO:0000269|PubMed:15452552, ECO:0000269|PubMed:1718267}.
uniprot
proteins
mass_dalton
46251
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11864635
uniprot
proteins
pubmed
1310144
uniprot
proteins
pubmed
1312928
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15452552
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
1657150
uniprot
proteins
pubmed
1659396
uniprot
proteins
pubmed
1718267
uniprot
proteins
pubmed
20937248
uniprot
proteins
pubmed
37968728
uniprot
proteins
pubmed
8384323
uniprot
proteins
sequence_length
407
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:37968728}; Multi-pass membrane protein {ECO:0000255}. Early endosome {ECO:0000250|UniProtKB:P14600}. Note=After signaling cascade initiation, substance P binding results in receptor internalization and localization to early endosomes, followed by receptor recycling to the cell surface. {ECO:0000250|UniProtKB:P14600}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..54; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 65..86; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 107..128; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 149..169; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 195..219; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 249..270; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 284..308; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins