TLR7
entrez
51284
canonical
uniprot
Q9NYK1
canonical
ensembl
ENSG00000196664
resolver
ensp
ENSP00000370034
resolver
enst
ENST00000380659
resolver
genesymbol
TLR7
resolver
hgnc
HGNC:15631
resolver
uniprot
B2R9N9
resolver
uniprot
D1CS69
resolver
uniprot
Q9NR98
resolver
uniprot_entry
B2R9N9_HUMAN
resolver
uniprot_entry
TLR7_HUMAN
resolver
uniprot_sec
D1CS69
resolver
uniprot_sec
Q9NR98
resolver
activity_regulation
ACTIVITY REGULATION: Activated by guanosine analogs including deoxyguanosine, 7-thia-8-oxoguanosine or 7-deazaguanosine in a RNA-independent manner. Activated by imiquimod (PubMed:32706371). {ECO:0000269|PubMed:12738885, ECO:0000269|PubMed:31608988, ECO:0000269|PubMed:32706371, ECO:0000269|PubMed:35477763}.
uniprot
proteins
amino_acid_sequence
MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTKDPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQAHPYFWQCLKNALATDNHVAYSQVFKETV
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency 74, COVID19-related, X-linked (IMD74) [MIM:301051]: An X-linked recessive immunologic disorder characterized by impaired type I and type II interferon responses due to defective TLR7 signaling. Individuals with TLR7 deficiency develop severe respiratory insufficiency in response to infection with SARS-CoV-2 coronavirus. Death from respiratory failure may occur. {ECO:0000269|PubMed:32706371}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Systemic lupus erythematosus 17 (SLEB17) [MIM:301080]: A form of systemic lupus erythematosus, a chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. SLEB17 is an X-linked dominant form characterized by onset of systemic autoinflammatory symptoms in the first decades of life. {ECO:0000269|PubMed:35477763}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Endosomal receptor that plays a key role in innate and adaptive immunity (PubMed:14976261, PubMed:32433612). Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs (PubMed:12738885, PubMed:27742543, PubMed:31608988, PubMed:32706371, PubMed:35477763). Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction (PubMed:27742543). In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively (PubMed:27742543, PubMed:32706371). In plasmacytoid dendritic cells, RNASET2 endonuclease cooperates with PLD3 or PLD4 5'->3' exonucleases to process RNA and release 2',3'-cyclic guanosine monophosphate (2',3'-cGMP) and cytidine-rich RNA fragments that occupy TLR7 ligand-binding pockets and trigger a signaling-competent state. {ECO:0000269|PubMed:12738885, ECO:0000269|PubMed:14976261, ECO:0000269|PubMed:27742543, ECO:0000269|PubMed:31608988, ECO:0000269|PubMed:32433612, ECO:0000269|PubMed:32706371, ECO:0000269|PubMed:35477763, ECO:0000269|PubMed:38697119}.
uniprot
proteins
mass_dalton
120922
uniprot
proteins
protein_family
Toll-like receptor family
uniprot
proteins
pubmed
11022119
uniprot
proteins
pubmed
11022120
uniprot
proteins
pubmed
12738885
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14976261
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18250417
uniprot
proteins
pubmed
19924287
uniprot
proteins
pubmed
27742543
uniprot
proteins
pubmed
31608988
uniprot
proteins
pubmed
32433612
uniprot
proteins
pubmed
32706371
uniprot
proteins
pubmed
33432245
uniprot
proteins
pubmed
35477763
uniprot
proteins
pubmed
38697119
uniprot
proteins
sequence_length
1049
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P58681}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P58681}. Endosome {ECO:0000250|UniProtKB:P58681}. Lysosome {ECO:0000250|UniProtKB:P58681}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:P58681}. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist. {ECO:0000250|UniProtKB:P58681}.
uniprot
proteins
transmembrane_region
TRANSMEM 840..860; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins