DAB2
entrez
1601
canonical
uniprot
P98082
canonical
ensembl
ENSG00000153071
resolver
ensp
ENSP00000313391
resolver
ensp
ENSP00000439919
resolver
genesymbol
DAB2
resolver
genesymbol_syn
DOC2
resolver
hgnc
HGNC:2662
resolver
uniprot
A6NES5
resolver
uniprot
B2RAW0
resolver
uniprot
Q13598
resolver
uniprot
Q9BTY0
resolver
uniprot
Q9UK04
resolver
uniprot_entry
B2RAW0_HUMAN
resolver
uniprot_entry
DAB2_HUMAN
resolver
uniprot_sec
A6NES5
resolver
uniprot_sec
Q13598
resolver
uniprot_sec
Q9BTY0
resolver
uniprot_sec
Q9UK04
resolver
amino_acid_sequence
MSNEVETSATNGQPDQQAAPKAPSKKEKKKGPEKTDEYLLARFKGDGVKYKAKLIGIDDVPDARGDKMSQDSMMKLKGMAAAGRSQGQHKQRIWVNISLSGIKIIDEKTGVIEHEHPVNKISFIARDVTDNRAFGYVCGGEGQHQFFAIKTGQQAEPLVVDLKDLFQVIYNVKKKEEEKKKIEEASKAVENGSEALMILDDQTNKLKSGVDQMDLFGDMSTPPDLNSPTESKDILLVDLNSEIDTNQNSLRENPFLTNGITSCSLPRPTPQASFLPENAFSANLNFFPTPNPDPFRDDPFTQPDQSTPSSFDSLKSPDQKKENSSSSSTPLSNGPLNGDVDYFGQQFDQISNRTGKQEAQAGPWPFSSSQTQPAVRTQNGVSEREQNGFSVKSSPNPFVGSPPKGLSIQNGVKQDLESSVQSSPHDSIAIIPPPQSTKPGRGRRTAKSSANDLLASDIFAPPVSEPSGQASPTGQPTALQPNPLDLFKTSAPAPVGPLVGLGGVTVTLPQAGPWNTASLVFNQSPSMAPGAMMGGQPSGFSQPVIFGTSPAVSGWNQPSPFAASTPPPVPVVWGPSASVAPNAWSTTSPLGNPFQSNIFPAPAVSTQPPSMHSSLLVTPPQPPPRAGPPKDISSDAFTALDPLGDKEIKDVKEMFKDFQLRQPPAVPARKGEQTSSGTLSAFASYFNSKVGIPQENADHDDFDANQLLNKINEPPKPAPRQVSLPVTKSTDNAFENPFFKDSFGSSQASVASSQPVSSEMYRDPFGNPFA
uniprot
proteins
function
FUNCTION: Adapter protein that functions as a clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containing non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage adhesion and spreading. May act as a tumor suppressor. {ECO:0000269|PubMed:11387212, ECO:0000269|PubMed:12805222, ECO:0000269|PubMed:16267015, ECO:0000269|PubMed:16984970, ECO:0000269|PubMed:19306879, ECO:0000269|PubMed:21995445, ECO:0000269|PubMed:22323290, ECO:0000269|PubMed:22491013}.
uniprot
proteins
mass_dalton
82448
uniprot
proteins
mutagenesis
MUTAGEN 166; /note="F->A: Impairs TGF-beta receptor signaling, no effect on interaction with SMAD2."; /evidence="ECO:0000269|PubMed:11387212"; MUTAGEN 684..686; /note="SYF->AAA: Greatly reduced binding to MYO6."; /evidence="ECO:0000269|PubMed:11967127"; MUTAGEN 720; /note="R->A: Abolishes interaction with SH3KBP1."; /evidence="ECO:0000269|PubMed:14596919
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation during mitosis is leading to membrane displacement (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
10340382
uniprot
proteins
pubmed
10769163
uniprot
proteins
pubmed
11161789
uniprot
proteins
pubmed
11387212
uniprot
proteins
pubmed
11967127
uniprot
proteins
pubmed
12805222
uniprot
proteins
pubmed
14596919
uniprot
proteins
pubmed
15134832
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16267015
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
16984970
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19306879
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21097498
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21995445
uniprot
proteins
pubmed
22323290
uniprot
proteins
pubmed
22484487
uniprot
proteins
pubmed
22491013
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8314147
uniprot
proteins
pubmed
8660969
uniprot
proteins
pubmed
9620555
uniprot
proteins
sequence_length
770
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Membrane, clathrin-coated pit. Note=Colocalizes with large insert-containing isoforms of MYO6 at clathrin-coated pits/vesicles. During mitosis is progressively displaced from the membrane and translocated to the cytoplasm.
uniprot
proteins