Acot9
entrez
56360
canonical
uniprot
Q9R0X4
canonical
ensembl
ENSMUSG00000025287
resolver
ensp
ENSMUSP00000026324
resolver
enst
ENSMUST00000026324
resolver
genesymbol
Acot9
resolver
genesymbol_syn
Acate2
resolver
uniprot
Q545G7
resolver
uniprot
Q9WTJ0
resolver
uniprot
Q9WUZ8
resolver
uniprot_entry
ACOT9_MOUSE
resolver
uniprot_sec
Q545G7
resolver
uniprot_sec
Q9WTJ0
resolver
uniprot_sec
Q9WUZ8
resolver
activity_regulation
ACTIVITY REGULATION: Strongly inhibited by NADH and CoA. {ECO:0000269|PubMed:23864032}.
uniprot
proteins
amino_acid_sequence
MKRAAIRLWTLNKGLLTHGRGLSQGSQYKISEPLHIHQVRDKLREIVGVSTVWRDHVKAMEERKLLHSFLPKSQKVLPPRKMRDSYIEVLLPLGTDPELRDKYVTVQNTVRFGRILEDLDSLGVLVCYMHNHNHSTKMSPLSIVTVLVDKIDMCKHSLSPEQDIKFTGHVSWVGNTSMEVKMKMFQLHNDEKYWPVLDATFVMVARDSENKGPAFVNPLIPENKEEEELFKQGELNKSRRIAFSTSSLLKVAPSSEERNIIHELFLTTLDPKTISFQSRILPPKAVWMEDTKLKSLDICHPQERNVFNRIFGGFLMRKAYELAWATACSFGGSRPYVVTVDDIMFQKPVEVGSLLFLSSQVCFTQDNYIQVRVHSEVSSLDSREHMTTNVFHFTFMSEKEVPLIFPKTYGESMLYLDGQRHFKSMSTPVTLKKDYPVEP
uniprot
proteins
ec_number
3.1.2.-
uniprot
proteins
ec_number
3.1.2.2
uniprot
proteins
function
FUNCTION: Mitochondrial acyl-CoA thioesterase. Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoA), regulating their respective intracellular levels (PubMed:10383425, PubMed:23864032). Shows a clear preference for hydrophobic short-, medium-, and long-chain saturated acyl-CoAs with some activity also with short-chain dicarboxylic CoA esters (PubMed:10383425, PubMed:23864032). Regulates both mitochondrial lipid and amino acid metabolism (PubMed:23864032, PubMed:31676684, PubMed:32498134). {ECO:0000269|PubMed:10383425, ECO:0000269|PubMed:23864032, ECO:0000269|PubMed:31676684, ECO:0000269|PubMed:32498134}.
uniprot
proteins
mass_dalton
50560
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid metabolism. {ECO:0000269|PubMed:23864032}.
uniprot
proteins
protein_family
Acyl coenzyme A hydrolase family
uniprot
proteins
pubmed
10383425
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21946561
uniprot
proteins
pubmed
23864032
uniprot
proteins
pubmed
31676684
uniprot
proteins
pubmed
32498134
uniprot
proteins
sequence_length
439
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305|PubMed:10383425}. Mitochondrion matrix {ECO:0000269|PubMed:31676684}. Mitochondrion inner membrane {ECO:0000269|PubMed:32498134}.
uniprot
proteins