Nlrx1
entrez
270151
canonical
uniprot
Q3TL44
canonical
ensembl
ENSMUSG00000032109
resolver
ensp
ENSMUSP00000034621
resolver
ensp
ENSMUSP00000126555
resolver
ensp
ENSMUSP00000127531
resolver
enst
ENSMUST00000034621
resolver
enst
ENSMUST00000168499
resolver
enst
ENSMUST00000169651
resolver
genesymbol
Nlrx1
resolver
uniprot
Q3UKJ1
resolver
uniprot
Q80W30
resolver
uniprot
Q8C249
resolver
uniprot_entry
NLRX1_MOUSE
resolver
uniprot_sec
Q3UKJ1
resolver
uniprot_sec
Q80W30
resolver
uniprot_sec
Q8C249
resolver
amino_acid_sequence
MRWGCHLPRTSWGSGLGRTPQLPDEHISFLIQWSWPFKGVHPLRPPRAFIRYHGNSADSAPPPGRHGQLFRSISATEAIQRHRRNLTEWFSRLPREERQFGPTFALDTVHVDPVIRESTPDELLRPSTELATGHQQTQAGLPPLALSQLFDPDSCGRRVQTVVLYGTVGTGKSTLVRKMVLDWCYGRLPAFELLIPFSCEDLSSLGSTPASLCQLVTQRYTPLKEVLPLMTAAGSRLLFVLHGLERLNLDFRLAGTGLCSDPEEPGPPAAIIVNLLRKYMLPEASILVTTRPSTISRIPSKYVGRYGEICGFSDTNLQKLYFQLRLNQPDCGYGAGGASVSVTPAQRDNLIQMLSRNLEGHHQIAAACFLPSYCWLVCATLHFLHAPTPAGQTLTSIYTSFLRLNFSGETLDSTHTSNLSLMSYAARTMGKLAYEGVSSRKTYFSEEDVRGCLEAGIKTEEEFQLLQIFRRDALRFFLAPCVEPGHLGTFVFTVPAMQEYLAALYIVLGLRKTALQRVGKEVVEFVGRVGEDVSLVLGIVAKLLPLRILPLLFNLLKVVPRVFGRMVSKSREAVAQAMVLEMFREEDYYNDDVLDQMGASILGVEGPRRHPDEPSEDEVFELFPMFMGGLLSAHNRAVLAQLGCPIKNLDALENAQAIKKKLGKLGRQVLPPSELLDHLFFHYEFQNQRFSAEVLGSLRQLNLAGVRMTPLKCTVVASVLGSGRHPLDEVNLASCQLDPAGLHTLMPVLLRARKLGLQLNNLGPEACRDLRDLLLHDQCQITTLRLSNNPLTAAGVGLLMDGLAGNTSVTHLSLLHTDLGDEGLELLAAQLDRNKQLQELNVAYNGAGDTVALALAKAAREHPSLELLHLYFNELSSEGRQVLRDLGGSGEGGARVVASLTEGTAVSEYWSVILSEVQRNVHSWDPLRVQRHLKLLLRDLEDSRGATLNPWRKAQLLRVEGEVKTLLEQLGGSGH
uniprot
proteins
function
FUNCTION: Participates in antiviral signaling (PubMed:35651602). Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (By similarity). Instead, promotes autophagy by interacting with TUFM and subsequently recruiting the autophagy-related proteins ATG5 and ATG12 (By similarity). Also regulates MAVS-dependent NLRP3 inflammasome activation to attenuate apoptosis (By similarity). Has no inhibitory function on NF-kappa-B signaling pathway, but enhances NF-kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (By similarity). Regulates viral mediated-inflammation and energy metabolism in a sex-dependent manner (PubMed:35651602). In females, prevents uncontrolled inflammation and energy metabolism and thus, may contribute to the sex differences observed in infectious and inflammatory diseases (PubMed:35651602). {ECO:0000250|UniProtKB:Q86UT6, ECO:0000269|PubMed:35651602}.
uniprot
proteins
mass_dalton
107831
uniprot
proteins
protein_family
NLRP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
35651602
uniprot
proteins
sequence_length
975
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q86UT6}.
uniprot
proteins