P21555
uniprot
P21555
canonical
amino_acid_sequence
MNSTLFSRVENYSVHYNVSENSPFLAFENDDCHLPLAVIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAVMCLPFTFVYTLMDHWVFGETMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYIGITVIWVLAVASSLPFVIYQILTDEPFQNVSLAAFKDKYVCFDKFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKIRDSKYRSSETKRINVMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKISMNDNEKI
uniprot
proteins
function
FUNCTION: Receptor for neuropeptide Y (NPY) and peptide YY (PYY). Can also bind with high affinity [Leu-31, Pro-34]NPY, an analog of NPY modified at residues 31 and 34 of the mature form, while having virtually no affinity for pancreatic polypeptide (PP/PPY) at physiological concentrations. NPY or PYY binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production. Receptor activation by ligands also leads to an increase of intracellular Ca(2+) levels. As a receptor for NPY, it is involved in the regulation of eating behavior and NPY-induced stimulation of food intake (By similarity). Involved in the regulation of colonic antisecretory tone, and colonic contractility (By similarity). {ECO:0000250|UniProtKB:P25929, ECO:0000250|UniProtKB:Q04573, ECO:0000250|UniProtKB:Q9WVD0}.
uniprot
proteins
mass_dalton
44117
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
2172008
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
382
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P25929}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P25929}.
uniprot
proteins
transmembrane_region
TRANSMEM 37..62; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P25929"; TRANSMEM 76..98; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P25929"; TRANSMEM 110..135; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P25929"; TRANSMEM 154..174; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P25929"; TRANSMEM 208..232; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P25929"; TRANSMEM 262..284; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P25929"; TRANSMEM 299..322; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P25929
uniprot
proteins