Grpel1
entrez
17713
canonical
uniprot
Q99LP6
canonical
ensembl
ENSMUSG00000029198
resolver
ensp
ENSMUSP00000031099
resolver
enst
ENSMUST00000031099
resolver
genesymbol
Grpel1
resolver
uniprot
Q3TSZ3
resolver
uniprot_entry
GRPE1_MOUSE
resolver
uniprot_sec
Q3TSZ3
resolver
amino_acid_sequence
MAARCVRLARRSLPALALSFRPSPRLLCTATKQKNNGQNLDEDLGHCEPKTDPPSADKTLLEEKAKLEEQLRETMEKYKRALADTENLRQRSQKLVEEAKLYGIQGFCKDLLEVADILEKATQSVPKEEISNNNPHLKSLYEGLVMTEVQIQKVFTKHGLLRLDPIGAKFDPYEHEALFHTPVEGKEPGTVALVSKVGYKLHGRTLRPALVGVVKDA
uniprot
proteins
function
FUNCTION: Nucleotide exchange factor (NEF) for mitochondrial HSP70 (HSPA9), facilitating the release of ADP from HSPA9 to allow ATP rebinding, which is essential for the chaperone cycle. Functions as a component of the presequence translocase-associated motor (PAM) complex, which drives ATP-dependent import of proteins into the mitochondrial matrix. In the PAM complex, supports the HSPA9-driven pulling mechanism that translocates polypeptides through the TIM23 complex. May control the nucleotide-dependent binding of HSPA9 to substrate proteins. {ECO:0000250|UniProtKB:Q9HAV7}.
uniprot
proteins
mass_dalton
24307
uniprot
proteins
protein_family
GrpE family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
30098457
uniprot
proteins
sequence_length
217
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:Q9HAV7}.
uniprot
proteins