ERG
entrez
2078
canonical
uniprot
P11308
canonical
ensembl
ENSG00000157554
resolver
ensp
ENSP00000288319
resolver
ensp
ENSP00000381871
resolver
ensp
ENSP00000381877
resolver
ensp
ENSP00000381891
resolver
ensp
ENSP00000394694
resolver
ensp
ENSP00000396268
resolver
ensp
ENSP00000414150
resolver
enst
ENST00000398905
resolver
enst
ENST00000453032
resolver
genesymbol
ERG
resolver
hgnc
HGNC:3446
resolver
uniprot
A0A0C4DG41
resolver
uniprot
A0A0D4D914
resolver
uniprot
B4DN83
resolver
uniprot
B4DTW5
resolver
uniprot
B4DVX5
resolver
uniprot
B4E0T4
resolver
uniprot
B5MDW0
resolver
uniprot
Q16113
resolver
uniprot
Q6XXX4
resolver
uniprot
Q6XXX5
resolver
uniprot
Q8IXK9
resolver
uniprot_entry
A0A0C4DG41_HUMAN
resolver
uniprot_entry
A0A0D4D914_HUMAN
resolver
uniprot_entry
B4DN83_HUMAN
resolver
uniprot_entry
B4DVX5_HUMAN
resolver
uniprot_entry
B5MDW0_HUMAN
resolver
uniprot_entry
ERG_HUMAN
resolver
uniprot_sec
B4DTW5
resolver
uniprot_sec
B4E0T4
resolver
uniprot_sec
Q16113
resolver
uniprot_sec
Q6XXX4
resolver
uniprot_sec
Q6XXX5
resolver
uniprot_sec
Q8IXK9
resolver
amino_acid_sequence
MASTIKEALSVVSEDQSLFECAYGTPHLAKTEMTASSSSDYGQTSKMSPRVPQQDWLSQPPARVTIKMECNPSQVNGSRNSPDECSVAKGGKMVGSPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNSPRLMHARNTGGAAFIFPNTSVYPEATQRITTRPDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPSHLGTYY
uniprot
proteins
disease_involvement
DISEASE: Ewing sarcoma (ES) [MIM:612219]: A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. {ECO:0000269|PubMed:8076344}. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving ERG has been found in patients with Erwing sarcoma. Translocation t(21;22)(q22;q12) with EWSR1. {ECO:0000269|PubMed:8076344}.; DISEASE: Note=Chromosomal aberrations involving ERG have been found in acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with FUS (PubMed:8187069). Translocation t(X;21)(q25-26;q22) with ELF4 (PubMed:16303180). {ECO:0000269|PubMed:16303180, ECO:0000269|PubMed:8187069}.; DISEASE: Lymphatic malformation 14 (LMPHM14) [MIM:620602]: A form of primary lymphedema, a disease characterized by swelling of body parts due to developmental anomalies and functional defects of the lymphatic system. Patients with lymphedema may suffer from recurrent local infections. LMPHM14 is an autosomal dominant form. {ECO:0000269|PubMed:36928819}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure.
uniprot
proteins
mass_dalton
53838
uniprot
proteins
protein_family
ETS family
uniprot
proteins
pubmed
14693372
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15351649
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303180
uniprot
proteins
pubmed
17289661
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
3299708
uniprot
proteins
pubmed
3476934
uniprot
proteins
pubmed
36928819
uniprot
proteins
pubmed
8076344
uniprot
proteins
pubmed
8187069
uniprot
proteins
pubmed
8290279
uniprot
proteins
sequence_length
479
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00237, ECO:0000269|PubMed:17289661}. Cytoplasm {ECO:0000269|PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
uniprot
proteins