Noxo1
entrez
71893
canonical
uniprot
Q8VCM2
canonical
ensembl
ENSMUSG00000019320
resolver
ensp
ENSMUSP00000019464
resolver
ensp
ENSMUSP00000230073
resolver
ensp
ENSMUSP00000230076
resolver
genesymbol
Noxo1
resolver
genesymbol_syn
Snx28
resolver
uniprot
Q3TZA4
resolver
uniprot
Q8BH41
resolver
uniprot
Q9D747
resolver
uniprot_entry
NOXO1_MOUSE
resolver
uniprot_sec
Q3TZA4
resolver
uniprot_sec
Q8BH41
resolver
uniprot_sec
Q9D747
resolver
amino_acid_sequence
MASPRHPVSAHAVALVQMDRLQTFAFSVCWSDNSDTFVRRSWDEFRQLQKTLKKTFPVEAGLLRRSEQVLPKLPDAPLLTRRGHTGRGLVRLRLLDTYVQALLATSEHILRSSALHGFFVPKPLDLEPMLPPGSLVILPTPEEPLSQPRGSLDIHSLEAQSIPCVQPFHTLDIRDRPFHTKAQEILDILLRHPSGWWLVENKDQQVAWFPAPYLEEVATCQGQESGLALQGSGRQFCTTQAYEGSRSDELSVPSGARVHVLETSDRGWWLCRYNGRTGLLPAMSLQPEGLGSLLGRPGFPDSAGADKVAEDRTIPPVVPTRPCMSAIQSRCCSITRRALGQEQGTRVPR
uniprot
proteins
function
FUNCTION: Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. {ECO:0000269|PubMed:12473664, ECO:0000269|PubMed:16431374}.
uniprot
proteins
mass_dalton
38827
uniprot
proteins
pubmed
12473664
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15949904
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16431374
uniprot
proteins
pubmed
17140397
uniprot
proteins
sequence_length
349
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17140397}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8NFA2}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8NFA2}. Note=Associates with the plasma membrane in a lipid-dependent manner. {ECO:0000250|UniProtKB:Q8NFA2}.
uniprot
proteins