P35226
uniprot
P35226
canonical
amino_acid_sequence
MHRTTRIKITELNPHLMCVLCGGYFIDATTIIECLHSFCKTCIVRYLETSKYCPICDVQVHKTRPLLNIRSDKTLQDIVYKLVPGLFKNEMKRRRDFYAAHPSADAANGSNEDRGEVADEDKRIITDDEIISLSIEFFDQNRLDRKVNKDKEKSKEEVNDKRYLRCPAAMTVMHLRKFLRSKMDIPNTFQIDVMYEEEPLKDYYTLMDIAYIYTWRRNGPLPLKYRVRPTCKRMKISHQRDGLTNAGELESDSGSDKANSPAGGIPSTSSCLPSPSTPVQSPHPQFPHISSTMNGTSNSPSGNHQSSFANRPRKSSVNGSSATSSG
uniprot
proteins
function
FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:15386022, PubMed:16359901, PubMed:16714294, PubMed:21772249, PubMed:25355358, PubMed:26151332, PubMed:27827373). The complex composed of RNF2, UB2D3 and BMI1 binds nucleosomes, and has activity only with nucleosomal histone H2A (PubMed:21772249, PubMed:25355358). In the PRC1-like complex, regulates the E3 ubiquitin-protein ligase activity of RNF2/RING2 (PubMed:15386022, PubMed:21772249, PubMed:26151332). {ECO:0000269|PubMed:15386022, ECO:0000269|PubMed:16359901, ECO:0000269|PubMed:16714294, ECO:0000269|PubMed:16882984, ECO:0000269|PubMed:21772249, ECO:0000269|PubMed:25355358, ECO:0000269|PubMed:26151332, ECO:0000269|PubMed:27827373}.
uniprot
proteins
mass_dalton
36949
uniprot
proteins
mutagenesis
MUTAGEN 62; /note="K->A: Strongly decreases histone H2A ubiquitination; when associated with A-64."; /evidence="ECO:0000269|PubMed:21772249"; MUTAGEN 64; /note="R->A: Mildly decreases histone H2A ubiquitination. Strongly decreases histone H2A ubiquitination; when associated with A-62."; /evidence="ECO:0000269|PubMed:21772249, ECO:0000269|PubMed:25355358"; MUTAGEN 73; /note="K->N: Increases stimulation of RNF2 ubiquitin ligase activity; when associated with E-77."; /evidence="ECO:0000269|PubMed:26151332"; MUTAGEN 77; /note="D->E: Increases stimulation of RNF2 ubiquitin ligase activity; when associated with N-73."; /evidence="ECO:0000269|PubMed:26151332"; MUTAGEN 165; /note="R->E: Decreases affinity for PHC2. Abolishes interaction with PHC2; when associated with E-174."; /evidence="ECO:0000269|PubMed:27827373"; MUTAGEN 170; /note="M->E: Strongly decreases affinity for PHC2."; /evidence="ECO:0000269|PubMed:27827373"; MUTAGEN 174; /note="H->E: Strongly decreases affinity for PHC2. Abolishes interaction with PHC2; when associated with E-165."; /evidence="ECO:0000269|PubMed:27827373
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated (By similarity). May be polyubiquitinated; which does not lead to proteasomal degradation. {ECO:0000250, ECO:0000269|PubMed:15897469}.
uniprot
proteins
pubmed
12167701
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15386022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15897469
uniprot
proteins
pubmed
16359901
uniprot
proteins
pubmed
16714294
uniprot
proteins
pubmed
16882984
uniprot
proteins
pubmed
19636380
uniprot
proteins
pubmed
21282530
uniprot
proteins
pubmed
21772249
uniprot
proteins
pubmed
25355358
uniprot
proteins
pubmed
26151332
uniprot
proteins
pubmed
27827373
uniprot
proteins
pubmed
8268912
uniprot
proteins
pubmed
8390036
uniprot
proteins
pubmed
9121482
uniprot
proteins
pubmed
9199346
uniprot
proteins
sequence_length
326
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16882984, ECO:0000269|PubMed:9199346}. Cytoplasm {ECO:0000269|PubMed:16882984}.
uniprot
proteins