Tti1
entrez
75425
canonical
uniprot
Q91V83
canonical
ensembl
ENSMUSG00000027650
resolver
ensp
ENSMUSP00000029179
resolver
ensp
ENSMUSP00000105148
resolver
ensp
ENSMUSP00000246883
resolver
enst
ENSMUST00000029179
resolver
enst
ENSMUST00000109522
resolver
genesymbol
Tti1
resolver
uniprot
Q7TS79
resolver
uniprot
Q9CSY0
resolver
uniprot_entry
TTI1_MOUSE
resolver
uniprot_sec
Q7TS79
resolver
uniprot_sec
Q9CSY0
resolver
amino_acid_sequence
MAVFDTPEEAFGVLRPVCVQLTKTQTVENVEHLQTQLQAISDTALQELQQYILFPLRFALKTPGPKRERLVQSVVECLTFVLSSTCVREQELLQELFSELSACLYSPSSQKPAALSEELKLAVIQGLSTLMHSAYRDIILTFYEPSILPRLGFAVSLLLGLAEQEKSKQIKIAALQCLQVLLLQCDCQDHPRPLDELEQQQLGDLLASFLPGISTALTRIITGDFKQGHSIVVSSLKVFYKTVGFIMADEQLTRIPKAQAKPVVEHRVAALMIHREADWVKSTGDKLAIFIKKIIDCVSVHPHWKVRLELVEFVEILLLKCTQSLVESTGPLLKVLVGLVNDESPEVQARCSTVLRRLADQKVVVGSRALADILSESLHSLATSLPRLMNTQDDQGKFSTLSLLLGYLKLLGPKVHVILNSVAHVQRLSRALIQVLELEVTDVKMVEERRWNSDNLSASAEVSAARPWSRVQRRYFRCFTDERVFLLLRKICQLLGYYGDLYLLVDHFMELYHTSVVYRKQAAMILNELVVGAAGLDVEDIHNKCPSMGPEELREIVKSILEEYTSQENWYLITCFEAEEGEEVMMKQQGFQAVTSGVHTCQVVSFPALSKPSPTICSMNSNIWQICIQLEGIGQFAYALGKDFRLLLMSALYPILEKAGDPTLLISQVATSTMVDICHACGYNSVQHLINQNSDYLVNGISLNLRHLALHPHAPKVLEAMLRNADASLLPLVADVVQDVLATLDQFYDKRAASFVSVLHALLAALAHWFPDSGSTGQLQQRSLEEEGRQLPAAGEASTTAEDIEQFVLSYLQEKDVAEGNVSDLEAEEEVQSAPPKVDENDTLPDVEPPLPTHIQIAKDVMERCIHLSADKNLKIRLKVLDVLGLCVEVLQTHKNQLLPLAHRAWPSLVHRLTSDDPLAVLRAFKVLQTLGSRCGDFLRSRFCKDVLPKLTSSLITQAPISARAGPVYSHTLAFKLQLAVLQGLGPLCENLDLGEGDLNKVADACVIYLSTKQPVKLQEAARSVFLHLMRVDPDSTWLLLHELYCPVQQFTAPHPSLHPVQLQGATQPQNPYATNVCHLLLQLQ
uniprot
proteins
function
FUNCTION: Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals (By similarity). {ECO:0000250|UniProtKB:O43156}.
uniprot
proteins
mass_dalton
120814
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-823 by CK2 following growth factor deprivation, leading to its subsequent ubiquitination by the SCF(FBXO9) complex. Phosphorylation by CK2 only takes place when TELO2 is bound to mTORC1, not mTORC2; leading to selective ubiquitination of mTORC1-associated protein (By similarity). {ECO:0000250|UniProtKB:O43156}.; PTM: Ubiquitinated by the SCF(FBXO9) complex following phosphorylation by CK2 in response to growth factor deprivation, leading to its degradation by the proteasome. Only mTORC1-associated protein is ubiquitinated and degraded, leading to selective inactivation of mTORC1 to restrain cell growth and protein translation, while mTORC2 is activated due to the relief of feedback inhibition by mTORC1 (By similarity). {ECO:0000250|UniProtKB:O43156}.
uniprot
proteins
protein_family
Tti1 family
uniprot
proteins
pubmed
11471062
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1085
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O43156}.
uniprot
proteins