NMNAT3
entrez
349565
canonical
uniprot
Q96T66
canonical
ensembl
ENSG00000163864
resolver
ensp
ENSP00000296202
resolver
ensp
ENSP00000340523
resolver
ensp
ENSP00000412953
resolver
ensp
ENSP00000426357
resolver
ensp
ENSP00000494285
resolver
ensp
ENSP00000495112
resolver
ensp
ENSP00000496061
resolver
ensp
ENSP00000496136
resolver
ensp
ENSP00000516041
resolver
ensp
ENSP00000543269
resolver
ensp
ENSP00000543270
resolver
ensp
ENSP00000614298
resolver
ensp
ENSP00000663961
resolver
ensp
ENSP00000663962
resolver
ensp
ENSP00000663964
resolver
ensp
ENSP00000685759
resolver
ensp
ENSP00000685760
resolver
ensp
ENSP00000685762
resolver
enst
ENST00000512391
resolver
enst
ENST00000642987
resolver
enst
ENST00000643695
resolver
enst
ENST00000645290
resolver
enst
ENST00000646611
resolver
genesymbol
NMNAT3
resolver
hgnc
HGNC:20989
resolver
uniprot
A0A2R8Y594
resolver
uniprot
A0A2R8YFG2
resolver
uniprot
A0A2R8YGL3
resolver
uniprot
B3KVR6
resolver
uniprot
D3DNF2
resolver
uniprot
D3DNF3
resolver
uniprot
D6RGH7
resolver
uniprot
Q49AL4
resolver
uniprot
Q8N4G1
resolver
uniprot_entry
A0A2R8Y594_HUMAN
resolver
uniprot_entry
A0A2R8YFG2_HUMAN
resolver
uniprot_entry
A0A2R8YGL3_HUMAN
resolver
uniprot_entry
D6RGH7_HUMAN
resolver
uniprot_entry
NMNA3_HUMAN
resolver
uniprot_entry
Q49AL4_HUMAN
resolver
uniprot_sec
B3KVR6
resolver
uniprot_sec
D3DNF2
resolver
uniprot_sec
D3DNF3
resolver
uniprot_sec
Q8N4G1
resolver
activity_regulation
ACTIVITY REGULATION: Activity is strongly inhibited by galotannin. Inhibited by P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate (Nap4AD). {ECO:0000269|PubMed:17402747}.
uniprot
proteins
amino_acid_sequence
MKSRIPVVLLACGSFNPITNMHLRMFEVARDHLHQTGMYQVIQGIISPVNDTYGKKDLAASHHRVAMARLALQTSDWIRVDPWESEQAQWMETVKVLRHHHSKLLRSPPQMEGPDHGKALFSTPAAVPELKLLCGADVLKTFQTPNLWKDAHIQEIVEKFGLVCVGRVGHDPKGYIAESPILRMHQHNIHLAKEPVQNEISATYIRRALGQGQSVKYLIPDAVITYIKDHGLYTKGSTWKGKSTQSTEGKTS
uniprot
proteins
ec_number
2.7.7.1
uniprot
proteins
ec_number
2.7.7.18
uniprot
proteins
function
FUNCTION: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP (PubMed:16118205, PubMed:17402747, PubMed:26616331). Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD(+), NADH, NaAD, nicotinic acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following injury (PubMed:16118205, PubMed:17402747). May be involved in the maintenance of axonal integrity (By similarity). Also functions as a stress-response chaperone protein that prevents toxic aggregation of proteins; this function may be independent of its NAD(+) synthesis activity (PubMed:18344983). {ECO:0000250|UniProtKB:Q99JR6, ECO:0000269|PubMed:16118205, ECO:0000269|PubMed:17402747, ECO:0000269|PubMed:18344983, ECO:0000269|PubMed:26616331}.
uniprot
proteins
mass_dalton
28322
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1. {ECO:0000305|PubMed:16118205, ECO:0000305|PubMed:17402747}.; PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1. {ECO:0000305|PubMed:16118205, ECO:0000305|PubMed:17402747}.
uniprot
proteins
protein_family
Eukaryotic NMN adenylyltransferase family
uniprot
proteins
pubmed
12574164
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16118205
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17402747
uniprot
proteins
pubmed
18344983
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26616331
uniprot
proteins
sequence_length
252
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:12574164, ECO:0000269|PubMed:16118205}.
uniprot
proteins