Glipr1l1
entrez
69286
canonical
uniprot
Q9DAG6
canonical
ensembl
ENSMUSG00000020213
resolver
ensp
ENSMUSP00000073302
resolver
ensp
ENSMUSP00000360661
resolver
enst
ENSMUST00000073617
resolver
genesymbol
Glipr1l1
resolver
uniprot_entry
GPRL1_MOUSE
resolver
amino_acid_sequence
MALKKKLNFLWTLVLYLIASRLPKAFGKDLPRVPTITDPKFIDAFLNIHNELRRKVQPPAADMNQLFWDQQLAKLAKAWTRECKLAHNPCIKQRYECLEDYDFIGENIYLGRIETQPEDVVINWYNESKYFNFDFNTCSEMCGHYTQVVWAKTVKIGCAVSNCPNLKGFSAGLFVCNYSPAGNFIGFRPYTRGDSCSMCGQKTCENSLCRPMNRKTPHHKAACHVLVLGFILQSLL
uniprot
proteins
function
FUNCTION: Required for optimal fertilization at the stage of sperm-oocyte fusion, plays a role in optimizing acrosome function, the translocation of IZUMO1 during the acrosome reaction and the fertilization process (PubMed:20219979, PubMed:31672133). Component of epididymosomes, one type of membranous microvesicules which mediate the transfer of lipids and proteins to spermatozoa plasma membrane during epididymal maturation. Also component of the CD9-positive microvesicules found in the cauda region. {ECO:0000250|UniProtKB:Q32LB5, ECO:0000269|PubMed:20219979, ECO:0000269|PubMed:31672133}.
uniprot
proteins
mass_dalton
27074
uniprot
proteins
post_translational_modification
PTM: N-glycosylated (PubMed:20219979). N-glycosylation decreases during the transit in the caput. {ECO:0000250|UniProtKB:Q32LB5, ECO:0000269|PubMed:20219979}.
uniprot
proteins
protein_family
CRISP family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20219979
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31672133
uniprot
proteins
sequence_length
236
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:20219979, ECO:0000269|PubMed:31672133}. Cell membrane {ECO:0000305|PubMed:20219979}; Peripheral membrane protein {ECO:0000305|PubMed:20219979}; Extracellular side {ECO:0000305|PubMed:20219979}. Membrane raft {ECO:0000269|PubMed:31672133}. Secreted {ECO:0000269|PubMed:20219979}. Note=Located in the connecting piece of elongated spermatids and sperm (PubMed:20219979, PubMed:31672133). Also located in the apical region of the sperm head after sperm capacitation (PubMed:20219979, PubMed:31672133). Weakly attached to the cell membrane and later secreted into the extracellular space (PubMed:20219979). Located on sperm equatorial segment and neck (By similarity). Associated with epididymosomes from the caput and cauda epididymis (By similarity). {ECO:0000250|UniProtKB:Q32LB5, ECO:0000269|PubMed:20219979, ECO:0000269|PubMed:31672133}.
uniprot
proteins