Fignl1
entrez
289777
canonical
uniprot
Q6GX84
canonical
ensembl
ENSRNOG00000004440
resolver
ensp
ENSRNOP00000078689
resolver
ensp
ENSRNOP00000101365
resolver
enst
ENSRNOT00000107994
resolver
enst
ENSRNOT00000134653
resolver
genesymbol
Fignl1
resolver
genesymbol_syn
S30
resolver
uniprot_entry
FIGL1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Ability to mediate disassembly of RAD51 filaments is inhibited by SWSAP1. Ability to mediate disassembly of RAD51 filaments is inhibited by BRCA2. {ECO:0000250|UniProtKB:Q6PIW4}.
uniprot
proteins
amino_acid_sequence
METSSSRSVQVDDWQKNYSVVASSICTPKQKADAYRALLLHIQDAYANSEISQVFATNLFKRYTEKYSAIIDSDNVVTGLNNYAESIFALAGSQQADSDKWQSGLSINNVFKMSTVQEMMQAGQKFKESLLEPADASVVMCKEPTIFEVPQLGVCGGSEEADLLSSSVHGTEKTQAIPGNSLRCSPFQSTLFPMATNTKTCLTSSAPSGESTTATFHRTPLFGNTKKEPQSFPKTSTGLNMFLSNPSCVPSGCENPRERKAFNDSDTINMLSNPTLNKAPSKTEDSGQREDNSLPTFKTAKEQLWADQKKRSHQSQHTSKSFNGAIKKSLGAGRSRGIFGKFVPPVSNKQDGSEQNGNVKPKSSRAGSAEPAHLTDDRLKNVEPRMVELIMNEIMDHGPPVHWEDIAGVEFAKATIKEIVVWPMMRPDIFTGLRGPPKGILLFGPPGTGKTLIGKCIASQSGATFFSISASSLTSKWVGEGEKMVRALFAVARCQQPAVIFIDEIDSLLSQRGDGEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARRRLVKRLYIPLPEASARKQIVVNLMSKEQCCLTDEETELVVQQSDGFSGADMTQLCREASLGPIRSLHTADIATISPDQVRPIAYIDFENAFRTVRPSVSPKDLELYENWNKTFGCGK
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: ATPase that maintains genome stability by acting as a key regulator of DNA double-strand break (DSB) repair via homologous recombination (HR). Regulates HR by mediating disassembly of RAD51 filaments from DNA and chromatin, thereby preventing DNA damage-independent RAD51 loading and persistent DNA accumulation of RAD51 recombinases. Also regulates HR during meiosis by mediating dissociation of DMC1 filaments from DNA (By similarity). May regulate osteoblast proliferation and differentiation (By similarity). {ECO:0000250|UniProtKB:Q6PIW4, ECO:0000250|UniProtKB:Q8BPY9}.
uniprot
proteins
mass_dalton
74197
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
pubmed
16288221
uniprot
proteins
sequence_length
677
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q6PIW4}. Nucleus {ECO:0000250|UniProtKB:Q6PIW4}. Cytoplasm {ECO:0000250|UniProtKB:Q6PIW4}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8BPY9}. Note=Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX-dependent manner. {ECO:0000250|UniProtKB:Q6PIW4}.
uniprot
proteins