Sh3bp5
entrez
117186
canonical
uniprot
Q91Y80
canonical
ensembl
ENSRNOG00000052391
resolver
ensp
ENSRNOP00000071111
resolver
ensp
ENSRNOP00000078582
resolver
genesymbol
Sh3bp5
resolver
genesymbol_syn
Sab
resolver
genesymbol_syn
Vesp18
resolver
uniprot_entry
3BP5_RAT
resolver
amino_acid_sequence
MDTALKRSRSEEPVELPPPAREAEEKEEEEERMEQGLEEEEEVDPRIQGELEKLNQSTDDINRRETELEDARQKFRSVLVEATVKLDELAKKIGKAVEDSKPYWEARRVARQAQLEAQKATQDFQRATEVLRAAKETISLAEQRLLEDDKRQFDSAWQEMLNHATQRVMEAEQTKTRSELVHKETAARYNAAMGRMRQLEKKLKRAINKSKPYFELKAKYYVQLEQLKKTVDDLQAKLALAKGEYKAALKSLERISDEIHERRRSNAMGPRGCGVGAEGSITSVENLPASKPEPDAISVASEAFEDDNCGNLVSEDDSETQSVSSFSSGPTSPSEMPDQFPAVARPGSLDLPSPVSLSEFGMMFPILGPRSECSGASSPECEVERGDRAEGAENKMSDKANNNRVLSSTSAGGGRSRSQSSTSLEGQALETRMKQLSLQCSKGREGIIADIKTVQIG
uniprot
proteins
function
FUNCTION: Functions as a guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25. Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death. {ECO:0000250|UniProtKB:O60239}.
uniprot
proteins
mass_dalton
50829
uniprot
proteins
mutagenesis
MUTAGEN 353; /note="S->A: Large decrease in phosphorylation by SAPK3."; /evidence="ECO:0000269|PubMed:15158451"; MUTAGEN 423; /note="S->A: Slight decrease in phosphorylation by SAPK3."; /evidence="ECO:0000269|PubMed:15158451
uniprot
proteins
protein_family
SH3BP5 family
uniprot
proteins
pubmed
15158451
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
457
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:O60239}; Peripheral membrane protein {ECO:0000250|UniProtKB:O60239}. Mitochondrion {ECO:0000269|PubMed:15158451}. Note=Colocalizes with RAB11A on cytoplasmic vesicle membranes. {ECO:0000250|UniProtKB:O60239}.
uniprot
proteins