PTPRM
entrez
5797
canonical
uniprot
P28827
canonical
ensembl
ENSG00000173482
resolver
ensp
ENSP00000331418
resolver
ensp
ENSP00000382927
resolver
ensp
ENSP00000463325
resolver
genesymbol
PTPRM
resolver
genesymbol_syn
PTPRL1
resolver
hgnc
HGNC:9675
resolver
uniprot
A7MBN1
resolver
uniprot
D3DUH8
resolver
uniprot
J3QL11
resolver
uniprot_entry
PTPRM_HUMAN
resolver
uniprot_sec
A7MBN1
resolver
uniprot_sec
D3DUH8
resolver
uniprot_sec
J3QL11
resolver
amino_acid_sequence
MRGLGTCLATLAGLLLTAAGETFSGGCLFDEPYSTCGYSQSEGDDFNWEQVNTLTKPTSDPWMPSGSFMLVNASGRPEGQRAHLLLPQLKENDTHCIDFHYFVSSKSNSPPGLLNVYVKVNNGPLGNPIWNISGDPTRTWNRAELAISTFWPNFYQVIFEVITSGHQGYLAIDEVKVLGHPCTRTPHFLRIQNVEVNAGQFATFQCSAIGRTVAGDRLWLQGIDVRDAPLKEIKVTSSRRFIASFNVVNTTKRDAGKYRCMIRTEGGVGISNYAELVVKEPPVPIAPPQLASVGATYLWIQLNANSINGDGPIVAREVEYCTASGSWNDRQPVDSTSYKIGHLDPDTEYEISVLLTRPGEGGTGSPGPALRTRTKCADPMRGPRKLEVVEVKSRQITIRWEPFGYNVTRCHSYNLTVHYCYQVGGQEQVREEVSWDTENSHPQHTITNLSPYTNVSVKLILMNPEGRKESQELIVQTDEDLPGAVPTESIQGSTFEEKIFLQWREPTQTYGVITLYEITYKAVSSFDPEIDLSNQSGRVSKLGNETHFLFFGLYPGTTYSFTIRASTAKGFGPPATNQFTTKISAPSMPAYELETPLNQTDNTVTVMLKPAHSRGAPVSVYQIVVEEERPRRTKKTTEILKCYPVPIHFQNASLLNSQYYFAAEFPADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRIYFQAASRANGETKIDCVQVATKGAATPKPVPEPEKQTDHTVKIAGVIAGILLFVIIFLGVVLVMKKRKLAKKRKETMSSTRQEMTVMVNSMDKSYAEQGTNCDEAFSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSYYPDETHTMASDTSSLVQSHTYKKREPADVPYQTGQLHPAIRVADLLQHITQMKCAEGYGFKEEYESFFEGQSAPWDSAKKDENRMKNRYGNIIAYDHSRVRLQTIEGDTNSDYINGNYIDGYHRPNHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGRVKCCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKRGVHEIREIRQFHFTGWPDHGVPYHATGLLGFVRQVKSKSPPSAGPLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYNCVRELRSRRVNMVQTEEQYVFIHDAILEACLCGDTSVPASQVRSLYYDMNKLDPQTNSSQIKEEFRTLNMVTPTLRVEDCSIALLPRNHEKNRCMDILPPDRCLPFLITIDGESSNYINAALMDSYKQPSAFIVTQHPLPNTVKDFWRLVLDYHCTSVVMLNDVDPAQLCPQYWPENGVHRHGPIQVEFVSADLEEDIISRIFRIYNAARPQDGYRMVQQFQFLGWPMYRDTPVSKRSFLKLIRQVDKWQEEYNGGEGRTVVHCLNGGGRSGTFCAISIVCEMLRHQRTVDVFHAVKTLRNNKPNMVDLLDQYKFCYEVALEYLNSG
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Receptor protein-tyrosine phosphatase that mediates homotypic cell-cell interactions and plays a role in adipogenic differentiation via modulation of p120 catenin/CTNND1 phosphorylation (PubMed:10753936, PubMed:17761881). Promotes CTNND1 dephosphorylation and prevents its cytoplasmic localization where it inhibits SLC2A4 membrane trafficking. In turn, SLC2A4 is directed to the plasma membrane and performs its glucose transporter function (PubMed:21998202). {ECO:0000269|PubMed:10753936, ECO:0000269|PubMed:16456543, ECO:0000269|PubMed:17761881, ECO:0000269|PubMed:21998202}.
uniprot
proteins
mass_dalton
163682
uniprot
proteins
mutagenesis
MUTAGEN 239; /note="R->E: Abolishes dimerization."; /evidence="ECO:0000269|PubMed:17761881"; MUTAGEN 240; /note="R->E: Abolishes dimerization."; /evidence="ECO:0000269|PubMed:17761881"; MUTAGEN 297; /note="Y->A: Abolishes dimerization."; /evidence="ECO:0000269|PubMed:17761881"; MUTAGEN 299; /note="W->A: Abolishes dimerization."; /evidence="ECO:0000269|PubMed:17761881
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
protein_family
Receptor class 2B subfamily
uniprot
proteins
pubmed
10753936
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
16456543
uniprot
proteins
pubmed
1655529
uniprot
proteins
pubmed
17761881
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21998202
uniprot
proteins
pubmed
9346878
uniprot
proteins
sequence_length
1452
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10753936}; Single-pass type I membrane protein. Note=Localizes in regions of cell-cell contact. {ECO:0000269|PubMed:10753936}.
uniprot
proteins
transmembrane_region
TRANSMEM 743..764; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins