Rft1
entrez
328370
canonical
uniprot
Q8C3B8
canonical
ensembl
ENSMUSG00000052395
resolver
ensp
ENSMUSP00000064153
resolver
ensp
ENSMUSP00000323892
resolver
ensp
ENSMUSP00000323893
resolver
ensp
ENSMUSP00000323904
resolver
ensp
ENSMUSP00000323906
resolver
genesymbol
Rft1
resolver
uniprot
B2RUN9
resolver
uniprot_entry
RFT1_MOUSE
resolver
uniprot_sec
B2RUN9
resolver
amino_acid_sequence
MGSQEVLGQAARLASSGLLLQVLFRLITFVLNAFILRFLSKEIVGIVNVRLTLLYSTTTFLAREAFRRACLSGGAQRDWSQTLNLLWLTVPLGIFWSSCLGWVWLQLLEVPDPDVVPYYGTGVLFFGLSAVVELLGEPFWVLAQAHMFVKLKVLAESMSVILRSVLTALLVLWLPHWGLYIFSLAQLLYTTVLVLCYAIYLIQLLRSPESAKQLTLPVSRVTQLLPSISRSRAFVNWKEAGLAWSFFKQSFLKQILTEGERYVMTFLNVLNFGDQGVYDIVNNLGSLVARLIFQPVEESFYLFFAKVLEREKDASLQKQDDVAVAAAVLESLLKLALLTGLTMTVFGFAYSQLALDIYGGAMLSSGSGPVLMRCYCLYVLLLAINGVTECFMFAAMSKEEVDRYNFTMLALSSSFLVLSYLLTSWCGSVGFIMANCFNMGIRITQSLSFIHHYFRESPHRPLAGLRLSPVLLGVFILSAGITSVSEAFLCCERGWPARLAHIAVGTICLGVTLGTAFLTETKLIHFLRTQLGRSRLSDKMT
uniprot
proteins
function
FUNCTION: Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues (By similarity). However, the intramembrane lipid transporter activity could not be confirmed in vitro (By similarity). {ECO:0000250|UniProtKB:P38206, ECO:0000250|UniProtKB:Q96AA3}.
uniprot
proteins
mass_dalton
60303
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:Q96AA3}.
uniprot
proteins
protein_family
RFT1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
541
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P38206}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 16..36; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 45..62; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 85..105; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 123..143; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 154..176; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 187..207; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 335..355; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 376..396; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 414..434; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 470..490; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 499..519; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins