SH3GL2
entrez
6456
canonical
uniprot
Q99962
canonical
ensembl
ENSG00000107295
resolver
ensp
ENSP00000369981
resolver
enst
ENST00000380607
resolver
genesymbol
SH3GL2
resolver
genesymbol_syn
CNSA2
resolver
genesymbol_syn
SH3D2A
resolver
hgnc
HGNC:10831
resolver
uniprot
B2R618
resolver
uniprot
Q9NQK5
resolver
uniprot_entry
SH3G2_HUMAN
resolver
uniprot_sec
B2R618
resolver
uniprot_sec
Q9NQK5
resolver
amino_acid_sequence
MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPKPSGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVALPH
uniprot
proteins
function
FUNCTION: Implicated in endocytosis. Involved ultrafast endocytosis, by mediating, in a first step, neck formation and in a second step, aids in the removal of clathrin coats from the regenerated vesicles. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes. {ECO:0000250|UniProtKB:Q62420}.
uniprot
proteins
mass_dalton
39962
uniprot
proteins
mutagenesis
MUTAGEN 63; /note="A->S: Reduced tubulation of liposomes, 3-fold increase in tubule diameter, no effect on liposome binding; when associated with S-66 or with S-66 and Q-70."; /evidence="ECO:0000269|PubMed:16763557"; MUTAGEN 66; /note="A->D: Loss of tubulation of liposomes, no effect on liposome binding."; /evidence="ECO:0000269|PubMed:16763557"; MUTAGEN 66; /note="A->S: Reduced tubulation of liposomes, 3-fold increase in tubule diameter, no effect on liposome binding; when associated with S-63 or with S-63 and Q-70."; /evidence="ECO:0000269|PubMed:16763557"; MUTAGEN 66; /note="A->W: Vesiculation of liposomes, no effect on liposome binding, indol ring located in hydrophobic core of the membrane."; /evidence="ECO:0000269|PubMed:16763557"; MUTAGEN 70; /note="M->Q: Reduced tubulation of liposomes, 3-fold increase in tubule diameter, no effect on liposome binding; when associated with S-63 and S-66."; /evidence="ECO:0000269|PubMed:16763557"; MUTAGEN 202; /note="F->W: No effect. Indol ring not associated with the membrane."; /evidence="ECO:0000269|PubMed:16763557
uniprot
proteins
protein_family
Endophilin family
uniprot
proteins
pubmed
10531379
uniprot
proteins
pubmed
10542231
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
16763557
uniprot
proteins
pubmed
17350572
uniprot
proteins
pubmed
18602463
uniprot
proteins
pubmed
23285027
uniprot
proteins
pubmed
28891236
uniprot
proteins
pubmed
9169142
uniprot
proteins
sequence_length
352
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O35179}. Membrane {ECO:0000250|UniProtKB:O35179}; Peripheral membrane protein {ECO:0000250|UniProtKB:O35179}. Early endosome {ECO:0000250|UniProtKB:Q62420}. Presynapse {ECO:0000250|UniProtKB:O35179}.
uniprot
proteins