Capn2
entrez
29154
canonical
uniprot
Q07009
canonical
ensembl
ENSRNOG00000034015
resolver
ensembl
ENSRNOG00055012648
resolver
ensembl
ENSRNOG00060007713
resolver
ensembl
ENSRNOG00065017813
resolver
ensp
ENSRNOP00000046509
resolver
ensp
ENSRNOP00055017508
resolver
ensp
ENSRNOP00060009674
resolver
ensp
ENSRNOP00065023675
resolver
enst
ENSRNOT00000045326
resolver
enst
ENSRNOT00055021594
resolver
enst
ENSRNOT00060012759
resolver
enst
ENSRNOT00065029816
resolver
genesymbol
Capn2
resolver
uniprot_entry
CAN2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by 200-1000 micromolar concentrations of calcium and inhibited by calpastatin.
uniprot
proteins
amino_acid_sequence
MAGIAMKLAKDREAAEGLGSHERAIKYLNQDYETLRNECLEAGALFQDPSFPALPSSLGFKELGPYSSKTRGIEWKRPTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLDQSFQENYAGIFHFQFWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGIAEWYELRKPPPNLFKIIQKALEKGSLLGCSIDITSAADSEAVTYQKLVKGHAYSVTGAEEVESSGSLQKLIRIRNPWGQVEWTGKWNDNCPSWNTVDPEVRANLTERQEDGEFWMSFSDFLRHYSRLEICNLTPDTLTCDSYKKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQYLIKLEEEDEDDEDGERGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPEELTGQTNIHLSKNFFLTTRARERSDTFINLREVLNRFKLPPGEYVLVPSTFEPHKNGDFCIRVFSEKKADYQTVDDEIEANIEEIEANEEDIGDGFRRLFAQLAGEDAEISAFELQTILRRVLAKREDIKSDGFSIETCKIMVDMLDEDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGTMNSYEMRKALEEAGFKLPCQLHQVIVARFADDELIIDFDNFVRCLVRLEILFKIFKQLDPENTGTIQLDLISWLSFSVL
uniprot
proteins
ec_number
3.4.22.53
uniprot
proteins
function
FUNCTION: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs. {ECO:0000250|UniProtKB:O08529, ECO:0000250|UniProtKB:P17655}.
uniprot
proteins
mass_dalton
79919
uniprot
proteins
mutagenesis
MUTAGEN 105; /note="C->S: Loss of activity."; /evidence="ECO:0000269|PubMed:7635186"; MUTAGEN 226; /note="K->S: 12% decrease in activity."; MUTAGEN 230; /note="K->E: 84% decrease in activity."; /evidence="ECO:0000269|PubMed:11102442"; MUTAGEN 230; /note="K->S: No effect."; /evidence="ECO:0000269|PubMed:11102442"; MUTAGEN 234; /note="K->E: 85% decrease in activity."; /evidence="ECO:0000269|PubMed:11102442"; MUTAGEN 234; /note="K->S: 20% decrease in activity."; /evidence="ECO:0000269|PubMed:11102442"; MUTAGEN 262; /note="H->A: Loss of activity."; /evidence="ECO:0000269|PubMed:7635186"; MUTAGEN 286; /note="N->A: Loss of activity."; /evidence="ECO:0000269|PubMed:7635186"; MUTAGEN 288; /note="W->Y: 95% decrease in activity."; /evidence="ECO:0000269|PubMed:7635186"; MUTAGEN 417; /note="R->A: Decreases catalytic activity."; /evidence="ECO:0000269|PubMed:19020622"; MUTAGEN 420; /note="R->A: Decreases catalytic activity."; /evidence="ECO:0000269|PubMed:19020622"; MUTAGEN 469; /note="R->A: Decreases catalytic activity."; /evidence="ECO:0000269|PubMed:19020622"; MUTAGEN 504; /note="E->S: 10% decrease in activity."; /evidence="ECO:0000269|PubMed:11102442
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated via 'Lys6'-linked chains by the E3 ubiquitin ligase complex at least composed of CUL3, KCTD7 and RBX1 to execute atypical, non-degradative ubiquitination. {ECO:0000250|UniProtKB:P17655}.
uniprot
proteins
protein_family
Peptidase C2 family
uniprot
proteins
pubmed
10601010
uniprot
proteins
pubmed
11102442
uniprot
proteins
pubmed
11342050
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19020622
uniprot
proteins
pubmed
19020623
uniprot
proteins
pubmed
7635186
uniprot
proteins
pubmed
8218419
uniprot
proteins
sequence_length
700
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Translocates to the plasma membrane upon Ca(2+) binding. {ECO:0000250}.
uniprot
proteins