IL9
entrez
3578
canonical
uniprot
P15248
canonical
ensembl
ENSG00000145839
resolver
ensp
ENSP00000274520
resolver
enst
ENST00000274520
resolver
genesymbol
IL9
resolver
hgnc
HGNC:6029
resolver
uniprot_entry
IL9_HUMAN
resolver
amino_acid_sequence
MLLAMVLTSALLLCSVAGQGCPTLAGILDINFLINKMQEDPASKCHCSANVTSCLCLGIPSDNCTRPCFSERLSQMTNTTMQTRYPLIFSRVKKSVEVLKNNKCPYFSCEQPCNQTTAGNALTFLKSLLEIFQKEKMRGMRGKI
uniprot
proteins
function
FUNCTION: Multifunctional cytokine secreted mainly by T-helper 2 lymphocytes and also mast cells or NKT cells that plays important roles in the immune response against parasites (PubMed:29742432). Affects intestinal epithelial permeability and adaptive immunity (PubMed:29742432). In addition, induces the differentiation of specific T-cell subsets such as IL-17 producing helper T-cells (TH17) and also proliferation and differentiation of mast cells. Mechanistically, exerts its biological effects through a receptor composed of IL9R subunit and a signal transducing subunit IL2RG. Receptor stimulation results in the rapid activation of JAK1 and JAK3 kinase activities leading to STAT1, STAT3 and STAT5-mediated transcriptional programs. Induction of differentiation genes seems to be mediated by STAT1 alone, while protection of cells from apoptosis depends on STAT3 and STAT5. {ECO:0000250|UniProtKB:P15247, ECO:0000269|PubMed:29742432}.
uniprot
proteins
mass_dalton
15909
uniprot
proteins
protein_family
IL-7/IL-9 family
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1901233
uniprot
proteins
pubmed
1971295
uniprot
proteins
pubmed
2129501
uniprot
proteins
pubmed
2508790
uniprot
proteins
pubmed
29742432
uniprot
proteins
sequence_length
144
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins