ITGA7
entrez
3679
canonical
uniprot
Q13683
canonical
ensembl
ENSG00000135424
resolver
ensp
ENSP00000257879
resolver
ensp
ENSP00000343009
resolver
ensp
ENSP00000393844
resolver
ensp
ENSP00000450578
resolver
ensp
ENSP00000452120
resolver
ensp
ENSP00000452387
resolver
ensp
ENSP00000558189
resolver
ensp
ENSP00000558194
resolver
ensp
ENSP00000558198
resolver
ensp
ENSP00000558199
resolver
ensp
ENSP00000558207
resolver
ensp
ENSP00000687536
resolver
enst
ENST00000347027
resolver
genesymbol
ITGA7
resolver
hgnc
HGNC:6143
resolver
uniprot
B4E3U0
resolver
uniprot
C9JMD3
resolver
uniprot
C9JMZ6
resolver
uniprot
J3KNV4
resolver
uniprot
O43197
resolver
uniprot
Q86W93
resolver
uniprot
Q9NY89
resolver
uniprot
Q9UET0
resolver
uniprot
Q9UEV2
resolver
uniprot_entry
ITA7_HUMAN
resolver
uniprot_entry
J3KNV4_HUMAN
resolver
uniprot_sec
B4E3U0
resolver
uniprot_sec
C9JMD3
resolver
uniprot_sec
C9JMZ6
resolver
uniprot_sec
O43197
resolver
uniprot_sec
Q86W93
resolver
uniprot_sec
Q9NY89
resolver
uniprot_sec
Q9UET0
resolver
uniprot_sec
Q9UEV2
resolver
amino_acid_sequence
MAGARSRDPWGASGICYLFGSLLVELLFSRAVAFNLDVMGALRKEGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQANRTGGLFACPLSLEETDCYRVDIDQGADMQKESKENQWLGVSVRSQGPGGKIVTCAHRYEARQRVDQILETRDMIGRCFVLSQDLAIRDELDGGEWKFCEGRPQGHEQFGFCQQGTAAAFSPDSHYLLFGAPGTYNWKGTARVELCAQGSADLAHLDDGPYEAGGEKEQDPRLIPVPANSYFGLLFVTNIDSSDPDQLVYKTLDPADRLPGPAGDLALNSYLGFSIDSGKGLVRAEELSFVAGAPRANHKGAVVILRKDSASRLVPEVMLSGERLTSGFGYSLAVADLNSDGWPDLIVGAPYFFERQEELGGAVYVYLNQGGHWAGISPLRLCGSPDSMFGISLAVLGDLNQDGFPDIAVGAPFDGDGKVFIYHGSSLGVVAKPSQVLEGEAVGIKSFGYSLSGSLDMDGNQYPDLLVGSLADTAVLFRARPILHVSHEVSIAPRSIDLEQPNCAGGHSVCVDLRVCFSYIAVPSSYSPTVALDYVLDADTDRRLRGQVPRVTFLSRNLEEPKHQASGTVWLKHQHDRVCGDAMFQLQENVKDKLRAIVVTLSYSLQTPRLRRQAPGQGLPPVAPILNAHQPSTQRAEIHFLKQGCGEDKICQSNLQLVRARFCTRVSDTEFQPLPMDVDGTTALFALSGQPVIGLELMVTNLPSDPAQPQADGDDAHEAQLLVMLPDSLHYSGVRALDPAEKPLCLSNENASHVECELGNPMKRGAQVTFYLILSTSGISIETTELEVELLLATISEQELHPVSARARVFIELPLSIAGMAIPQQLFFSGVVRGERAMQSERDVGSKVKYEVTVSNQGQSLRTLGSAFLNIMWPHEIANGKWLLYPMQVELEGGQGPGQKGLCSPRPNILHLDVDSRDRRRRELEPPEQQEPGERQEPSMSWWPVSSAEKKKNITLDCARGTANCVVFSCPLYSFDRAAVLHVWGRLWNSTFLEEYSAVKSLEVIVRANITVKSSIKNLMLRDASTVIPVMVYLDPMAVVAEGVPWWVILLAVLAGLLVLALLVLLLWKMGFFKRAKHPEATVPQYHAVKIPREDRQQFKEEKTGTILRNNWGSPRREGPDAHPILAADGHPELGPDGHPGPGTA
uniprot
proteins
disease_involvement
DISEASE: Muscular dystrophy congenital due to integrin alpha-7 deficiency (MDCI) [MIM:613204]: A form of congenital muscular dystrophy. Patients present at birth, or within the first few months of life, with hypotonia, muscle weakness and often with joint contractures. {ECO:0000269|PubMed:9590299}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as a Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. {ECO:0000250, ECO:0000269|PubMed:10694445, ECO:0000269|PubMed:17641293, ECO:0000269|PubMed:9307969}.
uniprot
proteins
mass_dalton
128948
uniprot
proteins
post_translational_modification
PTM: ADP-ribosylated on at least two sites of the extracellular domain in skeletal myotubes. {ECO:0000250}.; PTM: A 70 kDa form is created by proteolytic cleavage. Cleavage is elevated during myogenic differentiation and the cleaved form enhances cell adhesion and spreading on laminin. {ECO:0000269|PubMed:18940796}.
uniprot
proteins
protein_family
Integrin alpha chain family
uniprot
proteins
pubmed
10403775
uniprot
proteins
pubmed
10694445
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17641293
uniprot
proteins
pubmed
1839357
uniprot
proteins
pubmed
18940796
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
22779914
uniprot
proteins
pubmed
8126096
uniprot
proteins
pubmed
8626012
uniprot
proteins
pubmed
9307969
uniprot
proteins
pubmed
9352853
uniprot
proteins
pubmed
9473524
uniprot
proteins
pubmed
9590299
uniprot
proteins
sequence_length
1181
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 1083..1103; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins