BZW2
entrez
28969
canonical
uniprot
Q9Y6E2
canonical
ensembl
ENSG00000136261
resolver
ensp
ENSP00000258761
resolver
ensp
ENSP00000384617
resolver
ensp
ENSP00000397249
resolver
ensp
ENSP00000567418
resolver
ensp
ENSP00000567419
resolver
enst
ENST00000407633
resolver
genesymbol
BZW2
resolver
genesymbol_syn
5MP1
resolver
hgnc
HGNC:18808
resolver
uniprot
A4D123
resolver
uniprot
B5MCE7
resolver
uniprot
Q3B779
resolver
uniprot
Q96JW5
resolver
uniprot
Q9H3F7
resolver
uniprot_entry
5MP1_HUMAN
resolver
uniprot_entry
B5MCE7_HUMAN
resolver
uniprot_sec
A4D123
resolver
uniprot_sec
Q3B779
resolver
uniprot_sec
Q96JW5
resolver
uniprot_sec
Q9H3F7
resolver
amino_acid_sequence
MNKHQKPVLTGQRFKTRKRDEKEKFEPTVFRDTLVQGLNEAGDDLEAVAKFLDSTGSRLDYRRYADTLFDILVAGSMLAPGGTRIDDGDKTKMTNHCVFSANEDHETIRNYAQVFNKLIRRYKYLEKAFEDEMKKLLLFLKAFSETEQTKLAMLSGILLGNGTLPATILTSLFTDSLVKEGIAASFAVKLFKAWMAEKDANSVTSSLRKANLDKRLLELFPVNRQSVDHFAKYFTDAGLKELSDFLRVQQSLGTRKELQKELQERLSQECPIKEVVLYVKEEMKRNDLPETAVIGLLWTCIMNAVEWNKKEELVAEQALKHLKQYAPLLAVFSSQGQSELILLQKVQEYCYDNIHFMKAFQKIVVLFYKADVLSEEAILKWYKEAHVAKGKSVFLDQMKKFVEWLQNAEEESESEGEEN
uniprot
proteins
function
FUNCTION: Translation initiation regulator which represses non-AUG initiated translation and repeat-associated non-AUG (RAN) initiated translation by acting as a competitive inhibitor of eukaryotic translation initiation factor 5 (EIF5) function (PubMed:21745818, PubMed:28981728, PubMed:29470543, PubMed:34260931). Increases the accuracy of translation initiation by impeding EIF5-dependent translation from non-AUG codons by competing with it for interaction with EIF2S2 within the 43S pre-initiation complex (PIC) in an EIF3C-binding dependent manner (PubMed:21745818, PubMed:28981728, PubMed:34260931). {ECO:0000269|PubMed:21745818, ECO:0000269|PubMed:28981728, ECO:0000269|PubMed:29470543, ECO:0000269|PubMed:34260931}.
uniprot
proteins
mass_dalton
48162
uniprot
proteins
mutagenesis
MUTAGEN 380..391; /note="KWYKEAHVAKGK->QWYQEAQVAQGQ: Reduced interaction with EIF3C."; /evidence="ECO:0000269|PubMed:34260931"; MUTAGEN 401..411; /note="FVEWLQNAEEE->AAEAAQNAAAA: Reduced interaction with EIF2S2."; /evidence="ECO:0000269|PubMed:21745818, ECO:0000269|PubMed:34260931
uniprot
proteins
protein_family
BZW family
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21745818
uniprot
proteins
pubmed
25147208
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28981728
uniprot
proteins
pubmed
29470543
uniprot
proteins
pubmed
34260931
uniprot
proteins
sequence_length
419
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21745818}.
uniprot
proteins