Tex19.1
entrez
498033
canonical
uniprot
Q5XHY3
canonical
ensembl
ENSRNOG00000036670
resolver
ensembl
ENSRNOG00055031622
resolver
ensembl
ENSRNOG00060008636
resolver
ensembl
ENSRNOG00065005137
resolver
ensp
ENSRNOP00000051811
resolver
ensp
ENSRNOP00000107445
resolver
ensp
ENSRNOP00055045261
resolver
ensp
ENSRNOP00060011068
resolver
ensp
ENSRNOP00065005218
resolver
enst
ENSRNOT00000054928
resolver
enst
ENSRNOT00000134601
resolver
enst
ENSRNOT00055054755
resolver
enst
ENSRNOT00060014404
resolver
enst
ENSRNOT00065007536
resolver
genesymbol
Tex19.1
resolver
genesymbol_syn
Tex19a
resolver
uniprot_entry
TX19A_RAT
resolver
amino_acid_sequence
MCPPVSVRHGARGMSCLYGAWLYQLVHGEQMKMCFACFKAAFLLNKFYLEMGYWEQEELSEEEEEEEVWDAEPMEHLSESESLESDSKQDAGSEQDAGSEPNTRSEQDAWQGVGSLYVPQSVSEYGGPGALVPTPSWTQWVVFSISVPTELLPQEAVPLDLGPEDVEWTQALPWRLDVLFPCSHRLIPPLSWWDILDVMPSLGQPVLLELRSLWPLDQSVAQTWLQDQKFVLLLDSIHFMCHLLSMHVCWAVRTQVQHWQVLLNPGEMWVAHLKRVLFRPRGLYPWSLSILKSSDLGMELVPAAFYLRKKGFWVGSFLPWNSSIPETWSWDPGERLFITDATICATNYHFARSFFP
uniprot
proteins
function
FUNCTION: Required during spermatogenesis and placenta development, participating in the repression of retrotransposable elements and prevent their mobilization. Collaborates with the Piwi-interacting RNA (piRNA) pathway, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins. Interacts with Piwi proteins and directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Also during spermatogenesis, promotes, with UBR2, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis. Interacts with LINE-1 retrotransposon encoded LIRE1, stimulates LIRE1 polyubiquitination, mediated by UBR2, and degradation, inhibiting LINE-1 retrotransposon mobilization. {ECO:0000250|UniProtKB:Q99MV2}.
uniprot
proteins
mass_dalton
40855
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
356
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99MV2}. Note=Was initially reported to localize in the nucleus. However, it was later shown to localize in cytoplasm only. Cytoplasmic localization is distinct from the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250|UniProtKB:Q99MV2}.
uniprot
proteins