Hdgfl2
entrez
171073
canonical
uniprot
Q925G1
canonical
ensembl
ENSRNOG00000049142
resolver
genesymbol
Hdgfl2
resolver
genesymbol_syn
Hdgf3
resolver
genesymbol_syn
Hdgfrp2
resolver
uniprot
Q5PPH2
resolver
uniprot
Q68G63
resolver
uniprot_entry
HDGR2_RAT
resolver
uniprot_sec
Q5PPH2
resolver
uniprot_sec
Q68G63
resolver
amino_acid_sequence
MPHAFKPGDLVFAKMKGYPHWPARIDDIADGAVKPPPNKYPIFFFGTHETAFLGPKDLFPYDKCKDKYGKPNKRKGFNEGLWEIQNNPHASYSAPLPVSSSDSEAPEADLGGGSDADKEKEARRVMTVTAVTTTATSGRTESDSDSDKNSDHSGLKRKTPVLKMSVSKRARKASSDLDQASVSPSEEDSESPSESEKTSDQDFTPEKKTIARAPRRAPLGGRKKKKVPSASDSDSRADSDGAKEEPVVTAQPSPSSSSSSSSSSASDSDVSIKKPPRGRKPAEKPPPKPRGRRSKPERPPSTSSSDSDSDSGEVDRISEWKRRDEERRRELEARRRREQEEELRRLREQEREEKERRKERAERGGSSGEELEDEEPVKKRSRKARGRGTPSSSDSEPEGELGKEGKKLAKKSQLQGSESARKPGQKEKRGRPDEKPRARPVKVERTRKRSEGLSLDRKGEKKKEPSVEERLQKLHSEIKFALKVDNPDVRRCLSALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMAKAAEVYTRLKSRVLGPKVEALQKVNKAGAEKERADGEKVEEQPGEQAPRELAEDEPSTDRSAPVNGEAASQKGENTEDGAQEDGQDLEDGPRGGSSEELHDSPQDSSDPARPGNEHQDHERMQLASESADDDDEDS
uniprot
proteins
function
FUNCTION: Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C) (By similarity). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters (By similarity). Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs (By similarity). Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2 (By similarity). Involved in cellular growth control, through the regulation of cyclin D1 expression (By similarity). {ECO:0000250|UniProtKB:Q7Z4V5}.
uniprot
proteins
mass_dalton
74018
uniprot
proteins
protein_family
HDGF family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
26252862
uniprot
proteins
sequence_length
669
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26252862}. Cytoplasm {ECO:0000269|PubMed:26252862}.
uniprot
proteins