Tesk1
entrez
29460
canonical
uniprot
Q63572
canonical
ensembl
ENSRNOG00000053729
resolver
ensembl
ENSRNOG00055016877
resolver
ensembl
ENSRNOG00060004800
resolver
ensembl
ENSRNOG00065009759
resolver
ensp
ENSRNOP00000071965
resolver
ensp
ENSRNOP00055023093
resolver
ensp
ENSRNOP00060005982
resolver
ensp
ENSRNOP00065011864
resolver
enst
ENSRNOT00000080909
resolver
enst
ENSRNOT00055028670
resolver
enst
ENSRNOT00060007993
resolver
enst
ENSRNOT00065015695
resolver
genesymbol
Tesk1
resolver
uniprot_entry
TESK1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by autophosphorylation on Ser-215. Kinase activity is inhibited by SPRED1. {ECO:0000269|PubMed:10207045, ECO:0000269|PubMed:18216281}.
uniprot
proteins
amino_acid_sequence
MAGERPPLRGPGPGETPVEGPGGAGGGPGRGRPSSYRALRSAVSSLARVDDFDCAEKIGAGFFSEVYKVRHRQSGQVMVLKMNKLPSNRSNTLREVQLMNRLRHPNILRFMGVCVHQGQLHALTEYMNGGTLEQLLSSPEPLSWPVRLHLALDIAQGLRYLHAKGVFHRDLTSKNCLVRREDGGFTAVVGDFGLAEKIPVYREGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDFGLDVPAFRTLVGNDCPLPFLLLAIHCCSMEPSARAPFTEITQHLEQILEQLPEPTPLAKMPLAKAPLTYNQGSVPRGGPSATLPRSDPRLSRSRSDLFLPPSPESPPSWGDNLTRVNPFSLREDLRGGKIKLLDTPCKPATPLPLVPPSPLTSTQLPLVASPESLVQPETPVRRCRSLPSSPELPRRMETALPGPGPSPVGPSTEERMDCEGSSPEPEPPGPAPQLPLAVATDNFISTCSSASQPWSARPGPSLNNNPPAVVVNSPQGWAREPWNRAQHSLPRAAALERTEPSPPPSAPREQEEGLPCPGCCLSPFSFGFLSMCPRPTPAVARYRNLNCEAGSLLCHRGHHAKPPTPSLQLPGARS
uniprot
proteins
ec_number
2.7.12.1
uniprot
proteins
function
FUNCTION: Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues (PubMed:10207045). Regulates the cellular cytoskeleton by enhancing actin stress fiber formation via phosphorylation of cofilin and by preventing microtubule breakdown via inhibition of TAOK1/MARKK kinase activity (PubMed:11555644, PubMed:18216281). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (By similarity). Positively regulates integrin-mediated cell spreading, via phosphorylation of cofilin (By similarity). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of ciliary vesicle directional trafficking to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (By similarity). Probably plays a central role at and after the meiotic phase of spermatogenesis (PubMed:8537404). {ECO:0000250|UniProtKB:O70146, ECO:0000250|UniProtKB:Q15569, ECO:0000269|PubMed:10207045, ECO:0000269|PubMed:11555644, ECO:0000269|PubMed:18216281, ECO:0000269|PubMed:8537404}.
uniprot
proteins
mass_dalton
67988
uniprot
proteins
mutagenesis
MUTAGEN 170; /note="D->A: Loss of kinase and autophosphorylating activity. Abolishes TESK1-induced actin stress fiber formation. No effect on interaction with YWHAB, SPRY2 or SPRED1. No effect on TESK1-mediated dephosphorylation of SPRY2."; /evidence="ECO:0000269|PubMed:10207045, ECO:0000269|PubMed:11555644, ECO:0000269|PubMed:17974561, ECO:0000269|PubMed:18216281"; MUTAGEN 201; /note="Y->A: No effect on autophosphorylation."; /evidence="ECO:0000269|PubMed:10207045"; MUTAGEN 215; /note="S->A: Loss of autophosphorylation site, loss of kinase activity."; /evidence="ECO:0000269|PubMed:10207045"; MUTAGEN 215; /note="S->E: Loss of autophosphorylation site, no effect on kinase activity."; /evidence="ECO:0000269|PubMed:10207045"; MUTAGEN 217; /note="Y->A: No effect on autophosphorylation."; /evidence="ECO:0000269|PubMed:10207045"; MUTAGEN 439; /note="S->A: Abolishes interaction with YWHAB."; /evidence="ECO:0000269|PubMed:11555644
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated on serine and tyrosine residues. {ECO:0000269|PubMed:10207045}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
TKL Ser/Thr protein kinase family
uniprot
proteins
pubmed
10207045
uniprot
proteins
pubmed
11555644
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15817463
uniprot
proteins
pubmed
17974561
uniprot
proteins
pubmed
18216281
uniprot
proteins
pubmed
22302232
uniprot
proteins
pubmed
8537404
uniprot
proteins
sequence_length
628
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22302232}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:22302232}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q15569}. Cell projection, lamellipodium {ECO:0000269|PubMed:22302232}. Note=Colocalizes with SPRY4 in vesicular spots in the cytoplasm (By similarity). Localized to F-actin-rich lamellipodia at the cell periphery following fibronectin-mediated cell adhesion of Schwann cells (PubMed:22302232). {ECO:0000250|UniProtKB:Q15569, ECO:0000269|PubMed:22302232}.
uniprot
proteins