SAP30L
entrez
79685
canonical
uniprot
Q9HAJ7
canonical
ensembl
ENSG00000164576
resolver
ensp
ENSP00000297109
resolver
ensp
ENSP00000390927
resolver
ensp
ENSP00000416393
resolver
genesymbol
SAP30L
resolver
genesymbol_syn
NS4ATP2
resolver
hgnc
HGNC:25663
resolver
uniprot
E9PAU7
resolver
uniprot
E9PAY2
resolver
uniprot_entry
SP30L_HUMAN
resolver
uniprot_sec
E9PAU7
resolver
uniprot_sec
E9PAY2
resolver
amino_acid_sequence
MNGFSTEEDSREGPPAAPAAAAPGYGQSCCLIEDGERCVRPAGNASFSKRVQKSISQKKLKLDIDKSVRHLYICDFHKNFIQSVRNKRKRKTSDDGGDSPEHDTDIPEVDLFQLQVNTLRRYKRHYKLQTRPGFNKAQLAETVSRHFRNIPVNEKETLAYFIYMVKSNKSRLDQKSEGGKQLE
uniprot
proteins
function
FUNCTION: [Isoform 1]: Functions as a transcription repressor, probably via its interaction with histone deacetylase complexes (PubMed:16820529, PubMed:18070604). Involved in the functional recruitment of the class 1 Sin3-histone deacetylase complex (HDAC) to the nucleolus (PubMed:16820529). Binds DNA, apparently without sequence-specificity, and bends bound double-stranded DNA (PubMed:19015240). Binds phosphoinositol phosphates (phosphoinositol 3-phosphate, phosphoinositol 4-phosphate and phosphoinositol 5-phosphate) via the same basic sequence motif that mediates DNA binding and nuclear import (PubMed:19015240, PubMed:26609676). {ECO:0000269|PubMed:16820529, ECO:0000269|PubMed:18070604, ECO:0000269|PubMed:19015240, ECO:0000269|PubMed:26609676}.; FUNCTION: [Isoform 2]: Functions as a transcription repressor; isoform 2 has lower transcription repressor activity than isoform 1 and isoform 3. {ECO:0000269|PubMed:18070604}.; FUNCTION: [Isoform 3]: Functions as a transcription repressor; its activity is marginally lower than that of isoform 1. {ECO:0000269|PubMed:18070604}.
uniprot
proteins
mass_dalton
20877
uniprot
proteins
mutagenesis
MUTAGEN 88..90; /note="RKR->AAA: Strongly reduces affinity for DNA and for phosphoinositides."; /evidence="ECO:0000269|PubMed:19015240"; MUTAGEN 88..89; /note="RK->KS: Impairs nuclear localization."; /evidence="ECO:0000269|PubMed:14680513"; MUTAGEN 109..113; /note="Missing: Reduces transcriptional repressor activity, reduces localization in nucleoli, but has no effect on association with histone deacylase complexes."; /evidence="ECO:0000269|PubMed:18070604"; MUTAGEN 120..127; /note="RRYKRHYK->AAAAAAAA: Abolishes nucleolar localization."; /evidence="ECO:0000269|PubMed:16820529
uniprot
proteins
protein_family
SAP30 family
uniprot
proteins
pubmed
14680513
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16484223
uniprot
proteins
pubmed
16820529
uniprot
proteins
pubmed
18070604
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19015240
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26609676
uniprot
proteins
sequence_length
183
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Nucleus, nucleolus {ECO:0000269|PubMed:14680513, ECO:0000269|PubMed:16820529, ECO:0000269|PubMed:18070604, ECO:0000269|PubMed:19015240}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus, nucleolus {ECO:0000269|PubMed:18070604}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus, nucleolus {ECO:0000269|PubMed:18070604}.
uniprot
proteins