KBTBD2
entrez
25948
canonical
uniprot
Q8IY47
canonical
ensembl
ENSG00000170852
resolver
ensp
ENSP00000302586
resolver
ensp
ENSP00000566978
resolver
ensp
ENSP00000566979
resolver
ensp
ENSP00000566980
resolver
ensp
ENSP00000566981
resolver
ensp
ENSP00000566982
resolver
ensp
ENSP00000614882
resolver
ensp
ENSP00000614883
resolver
ensp
ENSP00000614884
resolver
ensp
ENSP00000614885
resolver
ensp
ENSP00000614886
resolver
enst
ENST00000304056
resolver
enst
ENST00000896919
resolver
enst
ENST00000896920
resolver
enst
ENST00000896921
resolver
enst
ENST00000896922
resolver
enst
ENST00000896923
resolver
enst
ENST00000944823
resolver
enst
ENST00000944824
resolver
enst
ENST00000944825
resolver
enst
ENST00000944826
resolver
enst
ENST00000944827
resolver
genesymbol
KBTBD2
resolver
genesymbol_syn
BKLHD1
resolver
genesymbol_syn
KIAA1489
resolver
hgnc
HGNC:21751
resolver
uniprot
A8K9T7
resolver
uniprot
Q86Y62
resolver
uniprot
Q9P239
resolver
uniprot
Q9UFM7
resolver
uniprot
Q9Y382
resolver
uniprot_entry
KBTB2_HUMAN
resolver
uniprot_sec
A8K9T7
resolver
uniprot_sec
Q86Y62
resolver
uniprot_sec
Q9P239
resolver
uniprot_sec
Q9UFM7
resolver
uniprot_sec
Q9Y382
resolver
amino_acid_sequence
MSTQDERQINTEYAVSLLEQLKLFYEQQLFTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSGLSESKQTHVHLRNVDAATLQIIITYAYTGNLAMNDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQDAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLWLEYNTESRSQYLSSVLSQIRIDALSEVTQRAWFQGLPPNDKSVVVQGLYKSMPKFFKPRLGMTKEEMMIFIEASSENPCSLYSSVCYSPQAEKVYKLCSPPADLHKVGTVVTPDNDIYIAGGQVPLKNTKTNHSKTSKLQTAFRTVNCFYWFDAQQNTWFPKTPMLFVRIKPSLVCCEGYIYAIGGDSVGGELNRRTVERYDTEKDEWTMVSPLPCAWQWSAAVVVHDCIYVMTLNLMYCYFPRSDSWVEMAMRQTSRSFASAAAFGDKIFYIGGLHIATNSGIRLPSGTVDGSSVTVEIYDVNKNEWKMAANIPAKRYSDPCVRAVVISNSLCVFMRETHLNERAKYVTYQYDLELDRWSLRQHISERVLWDLGRDFRCTVGKLYPSCLEESPWKPPTYLFSTDGTEEFELDGEMVALPPV
uniprot
proteins
function
FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of the insulin signaling pathway, modulating insulin sensitivity by limiting PIK3R1/p85alpha abundance in adipocytes. Targets PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase (PI3K), for 'Lys-48'-linked polyubiquitination and proteasome-mediated degradation. {ECO:0000269|PubMed:27708159}.
uniprot
proteins
mass_dalton
71331
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:27708159}.
uniprot
proteins
pubmed
10810093
uniprot
proteins
pubmed
10819331
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
27708159
uniprot
proteins
sequence_length
623
uniprot
proteins