Rpl5
entrez
81763
canonical
uniprot
P09895
canonical
ensembl
ENSRNOG00000023529
resolver
ensembl
ENSRNOG00055023963
resolver
ensembl
ENSRNOG00060011542
resolver
ensembl
ENSRNOG00065012667
resolver
ensp
ENSRNOP00000036514
resolver
ensp
ENSRNOP00055033494
resolver
ensp
ENSRNOP00060015346
resolver
ensp
ENSRNOP00065015887
resolver
enst
ENSRNOT00000030428
resolver
enst
ENSRNOT00055041165
resolver
enst
ENSRNOT00060019530
resolver
enst
ENSRNOT00065020643
resolver
genesymbol
Rpl5
resolver
uniprot_entry
RL5_RAT
resolver
amino_acid_sequence
MGFVKVVKNKAYFKRYQVRFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYEGQVEVNGDEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNNVTPDMMEEMYKKAHAAIRENPVYEKKPKREVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAAES
uniprot
proteins
function
FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs. It also couples ribosome biogenesis to p53/TP53 activation. As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53. {ECO:0000250|UniProtKB:P46777}.
uniprot
proteins
mass_dalton
34459
uniprot
proteins
protein_family
Universal ribosomal protein uL18 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
3117543
uniprot
proteins
pubmed
3624282
uniprot
proteins
pubmed
8626719
uniprot
proteins
sequence_length
297
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P46777}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P46777}. Note=Although RP5 is functional within the cytoplasm, the assembly of ribosomal subunits occurs in the nucleus. RPL5 nuclear import is mediated by IPO5/RanBP5, IPO7/RanBP7, KPNB1/importin-beta or TPNO1/Trn. {ECO:0000250|UniProtKB:P46777}.
uniprot
proteins