PROX1
entrez
5629
canonical
uniprot
Q92786
canonical
ensembl
ENSG00000117707
resolver
ensp
ENSP00000355925
resolver
ensp
ENSP00000400694
resolver
ensp
ENSP00000551078
resolver
ensp
ENSP00000551080
resolver
ensp
ENSP00000551081
resolver
ensp
ENSP00000551083
resolver
ensp
ENSP00000551084
resolver
ensp
ENSP00000551085
resolver
ensp
ENSP00000551086
resolver
ensp
ENSP00000551088
resolver
ensp
ENSP00000551089
resolver
enst
ENST00000366958
resolver
enst
ENST00000435016
resolver
enst
ENST00000881019
resolver
enst
ENST00000881022
resolver
enst
ENST00000881024
resolver
enst
ENST00000881026
resolver
enst
ENST00000881027
resolver
enst
ENST00000881029
resolver
genesymbol
PROX1
resolver
hgnc
HGNC:9459
resolver
uniprot
A6NK29
resolver
uniprot
A8K2B1
resolver
uniprot
Q5SW76
resolver
uniprot
Q8TB91
resolver
uniprot_entry
PROX1_HUMAN
resolver
uniprot_sec
A6NK29
resolver
uniprot_sec
A8K2B1
resolver
uniprot_sec
Q5SW76
resolver
uniprot_sec
Q8TB91
resolver
amino_acid_sequence
MPDHDSTALLSRQTKRRRVDIGVKRTVGTASAFFAKARATFFSAMNPQGSEQDVEYSVVQHADGEKSNVLRKLLKRANSYEDAMMPFPGATIISQLLKNNMNKNGGTEPSFQASGLSSTGSEVHQEDICSNSSRDSPPECLSPFGRPTMSQFDMDRLCDEHLRAKRARVENIIRGMSHSPSVALRGNENEREMAPQSVSPRESYRENKRKQKLPQQQQQSFQQLVSARKEQKREERRQLKQQLEDMQKQLRQLQEKFYQIYDSTDSENDEDGNLSEDSMRSEILDARAQDSVGRSDNEMCELDPGQFIDRARALIREQEMAENKPKREGNNKERDHGPNSLQPEGKHLAETLKQELNTAMSQVVDTVVKVFSAKPSRQVPQVFPPLQIPQARFAVNGENHNFHTANQRLQCFGDVIIPNPLDTFGNVQMASSTDQTEALPLVVRKNSSDQSASGPAAGGHHQPLHQSPLSATTGFTTSTFRHPFPLPLMAYPFQSPLGAPSGSFSGKDRASPESLDLTRDTTSLRTKMSSHHLSHHPCSPAHPPSTAEGLSLSLIKSECGDLQDMSEISPYSGSAMQEGLSPNHLKKAKLMFFYTRYPSSNMLKTYFSDVKFNRCITSQLIKWFSNFREFYYIQMEKYARQAINDGVTSTEELSITRDCELYRALNMHYNKANDFEVPERFLEVAQITLREFFNAIIAGKDVDPSWKKAIYKVICKLDSEVPEIFKSPNCLQELLHE
uniprot
proteins
function
FUNCTION: Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. {ECO:0000269|PubMed:23723244, ECO:0000303|PubMed:22733308}.
uniprot
proteins
mass_dalton
83203
uniprot
proteins
protein_family
Prospero homeodomain family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
22733308
uniprot
proteins
pubmed
22733734
uniprot
proteins
pubmed
23723244
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
8812486
uniprot
proteins
sequence_length
737
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P48437}. Note=RORG promotes its nuclear localization. {ECO:0000250|UniProtKB:P48437}.
uniprot
proteins