Igfbp3
entrez
24484
canonical
uniprot
P15473
canonical
ensembl
ENSRNOG00000061910
resolver
ensp
ENSRNOP00000073137
resolver
enst
ENSRNOT00000088355
resolver
genesymbol
Igfbp3
resolver
genesymbol_syn
Igfbp-3
resolver
uniprot
A0A0G2K4Q9
resolver
uniprot
A1A5Q9
resolver
uniprot_entry
A0A0G2K4Q9_RAT
resolver
uniprot_entry
A1A5Q9_RAT
resolver
uniprot_entry
IBP3_RAT
resolver
amino_acid_sequence
MHPARPALWAAALTALTLLRGPPVARAGAGAVGAGPVVRCEPCDARALAQCAPPPTAPACTELVREPGCGCCLTCALREGDACGVYTERCGTGLRCQPRPAEQYPLKALLNGRGFCANASAASNLSAYLPSQPSPGNTTESEEDHNAGSVESQVVPSTHRVTDSKFHPLHSKMEVIIKGQARDSQRYKVDYESQSTDTQNFSSESKRETEYGPCRREMEDTLNHLKFLNVLSPRGVHIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKYGQPLPGYDTKGKDDVHCLSVQSQ
uniprot
proteins
function
FUNCTION: Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R. Inhibits the positive effect of humanin on insulin sensitivity. Promotes testicular germ cell apoptosis. Acts via LRP-1/alpha2M receptor, also known as TGF-beta type V receptor, to mediate cell growth inhibition independent of IGF1. Mechanistically, induces serine-specific dephosphorylation of IRS1 or IRS2 upon ligation to its receptor, leading to the inhibitory cascade. In the nucleus, interacts with transcription factors such as retinoid X receptor-alpha/RXRA to regulate transcriptional signaling and apoptosis. {ECO:0000250|UniProtKB:P17936}.
uniprot
proteins
mass_dalton
31680
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by FAM20C in the extracellular medium. Phosphorylated by CK2; resulting in decreased nuclear localization. {ECO:0000250|UniProtKB:P17936}.
uniprot
proteins
pubmed
1689154
uniprot
proteins
pubmed
2443135
uniprot
proteins
pubmed
2480123
uniprot
proteins
pubmed
2480787
uniprot
proteins
pubmed
3190697
uniprot
proteins
sequence_length
292
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P17936}. Nucleus {ECO:0000250|UniProtKB:P17936}.
uniprot
proteins