Rock1
entrez
19877
canonical
uniprot
P70335
canonical
ensembl
ENSMUSG00000024290
resolver
ensp
ENSMUSP00000069549
resolver
ensp
ENSMUSP00000214276
resolver
genesymbol
Rock1
resolver
uniprot
Q3UE22
resolver
uniprot
Q8C3G4
resolver
uniprot
Q8C7H0
resolver
uniprot_entry
Q3UE22_MOUSE
resolver
uniprot_entry
ROCK1_MOUSE
resolver
uniprot_sec
Q8C3G4
resolver
uniprot_sec
Q8C7H0
resolver
activity_regulation
ACTIVITY REGULATION: Activated by RHOA binding. Inhibited by Y-27632 (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MSTGDSFETRFEKIDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEDKGDEETFPIPKAFVGNQLPFVGFTYYSNRRYLPSANASENRSSSNVDKSLQESLQKTIYKLEEQLHNEMQLKDEMEQKCRTSNLKLDKIMKELDEEGNQRRNLESAVSQIEKEKMLLQHRINEYQRKVEQENEKRRNIENEVSTLKDQLEDLRKASQTSQLANEKLTQLQKQLEEANDLLRTESDTAVRLRKSHTEMSKSISQLESLNRELQERNRILENSKSQADKDYYQLQAVLEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLERVEGERKEAQDMLNHSEKEKNNLEIDLNYKLKSIQQRLEQEVNEHKVTKARLTDKHQSIEEAKSVAMCEMEKKLKEEREAREKAENRVVETEKQCSMLDVDLKQSQQKLEHLTENKERMEDEVKNLALQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLRKIQELQSEKETLSTQLDLAETKAESEQLARGILEEQYFELTQESKKAASRNRQEITDKDHTVSRLEETNSVLTKDIEMLRKENEELNERMRTAEEEYKLKKEEEINNLKAAFEKNISTERTLKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLVEECTHRNELQMQLASKESDIEQLRAKLLDLSDSTSVASFPSADETDGNLPESRIEGWLSVPNRGNIKRYGWKKQYVVVSSKKILFYNDEQDKEQSSPSMVLDIDKLFHVRPVTQGDVYRAETEEIPKIFQILYANEGECRKDIEVEPVQQGEKTNFQNHKGHEFIPTLYHFPANCEACAKPLWHVFKPPPALECRRCHVKCHRDHLDKKEDLISPCKVSYDVTSARDMLLLACSQDEQKKWVTHLVKKIPKNPPSGFVRASPRTLSTRSTANQSFRKVVKNTSGKTS
uniprot
proteins
ec_number
2.7.11.39
uniprot
proteins
function
FUNCTION: Protein kinase which is a key regulator of the actin cytoskeleton and cell polarity (PubMed:19036714, PubMed:19181962). Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A (PubMed:19036714, PubMed:19181962). Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress (By similarity). Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability (PubMed:20008297). Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis (By similarity). Plays a role in terminal erythroid differentiation (By similarity). Inhibits podocyte motility via regulation of actin cytoskeletal dynamics and phosphorylation of CFL1 (PubMed:30115939). Promotes keratinocyte terminal differentiation (By similarity). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization (PubMed:21768292). May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles (PubMed:15753128). {ECO:0000250|UniProtKB:Q13464, ECO:0000250|UniProtKB:Q8MIT6, ECO:0000269|PubMed:15753128, ECO:0000269|PubMed:19036714, ECO:0000269|PubMed:19181962, ECO:0000269|PubMed:20008297, ECO:0000269|PubMed:21768292, ECO:0000269|PubMed:30115939}.
uniprot
proteins
mass_dalton
158171
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated on serine and threonine residues.; PTM: Cleaved by caspase-3 during apoptosis. This leads to constitutive activation of the kinase and membrane blebbing (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15753128
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16741948
uniprot
proteins
pubmed
17654484
uniprot
proteins
pubmed
19036714
uniprot
proteins
pubmed
19181962
uniprot
proteins
pubmed
20008297
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21768292
uniprot
proteins
pubmed
22493320
uniprot
proteins
pubmed
30115939
uniprot
proteins
pubmed
8772201
uniprot
proteins
sequence_length
1354
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16741948}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:16741948}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q13464}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q13464}. Cell projection, bleb {ECO:0000250|UniProtKB:Q13464}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16741948}. Cell membrane {ECO:0000269|PubMed:16741948}. Cell projection, lamellipodium {ECO:0000269|PubMed:16741948}. Cell projection, ruffle {ECO:0000269|PubMed:16741948}. Note=A small proportion is associated with Golgi membranes (By similarity). Associated with the mother centriole and an intercentriolar linker (PubMed:16741948). Colocalizes with ITGB1BP1 and ITGB1 at the cell membrane predominantly in lamellipodia and membrane ruffles, but also in retraction fibers (PubMed:16741948). Localizes at the cell membrane in an ITGB1BP1-dependent manner (PubMed:16741948). {ECO:0000250|UniProtKB:Q13464, ECO:0000269|PubMed:16741948}.
uniprot
proteins