CYP2A6
entrez
1548
canonical
uniprot
P11509
canonical
ensembl
ENSG00000255974
resolver
ensp
ENSP00000301141
resolver
enst
ENST00000301141
resolver
genesymbol
CYP2A6
resolver
genesymbol_syn
CYP2A3
resolver
hgnc
HGNC:2610
resolver
uniprot
A7YAE5
resolver
uniprot
B2R7F6
resolver
uniprot
P00190
resolver
uniprot
P10890
resolver
uniprot
Q16803
resolver
uniprot
Q4VAT9
resolver
uniprot
Q4VAU0
resolver
uniprot
Q4VAU1
resolver
uniprot
Q9H1Z7
resolver
uniprot
Q9UCU0
resolver
uniprot
Q9UK48
resolver
uniprot_entry
CP2A6_HUMAN
resolver
uniprot_sec
A7YAE5
resolver
uniprot_sec
B2R7F6
resolver
uniprot_sec
P00190
resolver
uniprot_sec
P10890
resolver
uniprot_sec
Q16803
resolver
uniprot_sec
Q4VAT9
resolver
uniprot_sec
Q4VAU0
resolver
uniprot_sec
Q4VAU1
resolver
uniprot_sec
Q9H1Z7
resolver
uniprot_sec
Q9UCU0
resolver
uniprot_sec
Q9UK48
resolver
amino_acid_sequence
MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR
uniprot
proteins
ec_number
1.14.14.-
uniprot
proteins
function
FUNCTION: Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide, ifosphamide and tegafur. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity. {ECO:0000269|PubMed:11695850, ECO:0000269|PubMed:12042667, ECO:0000269|PubMed:16086027, ECO:0000269|PubMed:17125252, ECO:0000269|PubMed:18779312, ECO:0000269|PubMed:1889415, ECO:0000269|PubMed:1944238}.
uniprot
proteins
mass_dalton
56517
uniprot
proteins
mutagenesis
MUTAGEN 208; /note="I->S: Increases phenacetin O-deethylation activity 10 fold; when associated with F-300 and A-301. Increases phenacetin O-deethylation activity 38 fold; when associated with F-300; A-301 and G-369."; /evidence="ECO:0000269|PubMed:18779312"; MUTAGEN 213; /note="S->A: No effect on phenacetin O-deethylation activity."; /evidence="ECO:0000269|PubMed:18779312"; MUTAGEN 300; /note="I->F: Increases phenacetin O-deethylation activity 3 fold. Increases phenacetin O-deethylation activity 8 fold; when associated with A-301. Increases phenacetin O-deethylation activity 10 fold; when associated with S-208 and A-301. Increases phenacetin O-deethylation activity 12 fold; when associated with A-301 and G-369. Increases phenacetin O-deethylation activity 38 fold; when associated with S-208; A-301 and G-369."; /evidence="ECO:0000269|PubMed:18779312"; MUTAGEN 301; /note="G->A: Slightly decreases phenacetin O-deethylation activity. Increases phenacetin O-deethylation activity 8 fold; when associated with F-300. Increases phenacetin O-deethylation activity 10 fold; when associated with S-208 and F-300. Increases phenacetin O-deethylation activity 12 fold; when associated with F-300 and G-369. Increases phenacetin O-deethylation activity 38 fold; when associated with S-208; F-300 and G-369."; /evidence="ECO:0000269|PubMed:18779312"; MUTAGEN 369; /note="S->G: Increases phenacetin O-deethylation activity 3 fold. Increases phenacetin O-deethylation activity 38 fold; when associated with S-208; F-300 and A-301."; /evidence="ECO:0000269|PubMed:18779312"; MUTAGEN 372; /note="R->H: Increases phenacetin O-deethylation activity 2 fold."; /evidence="ECO:0000269|PubMed:18779312
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
10544257
uniprot
proteins
pubmed
11237731
uniprot
proteins
pubmed
11278503
uniprot
proteins
pubmed
11695850
uniprot
proteins
pubmed
12042667
uniprot
proteins
pubmed
12721789
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15469410
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15618701
uniprot
proteins
pubmed
16086027
uniprot
proteins
pubmed
17125252
uniprot
proteins
pubmed
18216723
uniprot
proteins
pubmed
18360915
uniprot
proteins
pubmed
18779312
uniprot
proteins
pubmed
1889415
uniprot
proteins
pubmed
1944238
uniprot
proteins
pubmed
2322567
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2726448
uniprot
proteins
pubmed
2748347
uniprot
proteins
pubmed
3856261
uniprot
proteins
pubmed
9409631
uniprot
proteins
sequence_length
494
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
uniprot
proteins