Sytl2
entrez
83671
canonical
uniprot
Q99N50
canonical
ensembl
ENSMUSG00000030616
resolver
ensp
ENSMUSP00000102828
resolver
ensp
ENSMUSP00000102829
resolver
ensp
ENSMUSP00000139450
resolver
ensp
ENSMUSP00000139865
resolver
ensp
ENSMUSP00000158976
resolver
ensp
ENSMUSP00000158979
resolver
enst
ENSMUST00000190365
resolver
enst
ENSMUST00000239078
resolver
genesymbol
Sytl2
resolver
genesymbol_syn
Slp2
resolver
genesymbol_syn
mKIAA1597
resolver
uniprot
A0A5F8MPH5
resolver
uniprot
A0A5F8MPX2
resolver
uniprot
B2RS48
resolver
uniprot
B7ZNS4
resolver
uniprot
Q69ZF4
resolver
uniprot
Q7TMU6
resolver
uniprot
Q8BT37
resolver
uniprot
Q99J89
resolver
uniprot
Q99J90
resolver
uniprot
Q99N51
resolver
uniprot
Q99N52
resolver
uniprot
Q99N55
resolver
uniprot
Q99N56
resolver
uniprot_entry
A0A5F8MPH5_MOUSE
resolver
uniprot_entry
A0A5F8MPX2_MOUSE
resolver
uniprot_entry
Q69ZF4_MOUSE
resolver
uniprot_entry
Q7TMU6_MOUSE
resolver
uniprot_entry
SYTL2_MOUSE
resolver
uniprot_sec
B2RS48
resolver
uniprot_sec
B7ZNS4
resolver
uniprot_sec
Q8BT37
resolver
uniprot_sec
Q99J89
resolver
uniprot_sec
Q99J90
resolver
uniprot_sec
Q99N51
resolver
uniprot_sec
Q99N52
resolver
uniprot_sec
Q99N55
resolver
uniprot_sec
Q99N56
resolver
amino_acid_sequence
MIDLSFLTEEEQDAILKVLQRDAALKRAEEERVRHLPEKIKDDQQLKNMSGQWFYEAKAKRHRDKIHGADIIRASMRRKKLPAAAEQNKDTAMRAKESWVNNVNKDAVLPPEIAVVEEPEDDTDPAGPSSSLVDPASSVIDMSQESTRTPAVSLPKQRKNPFNSPKLPEDHSLQQTKPEQSKTGKAGLFQISKEGELSESKEKSSIPDMPRQQLEKPKQTVSTEPENASHTKAPIPKARKLIYKSNDLEKDDNQSFPRQRRDSLNARGAPRGILKRNSSSSSTDSETLRLNYNLDPKSKILSPGLTIHERISEKEFSLEDDSSTSSLEPLKHVRFSAVKNELPQSPRPVLGQEVGEFTVLESDQLQNGTEDAGDIEEFQNHPELSHKTPLSHYQLVSSPSDSGREREQLMSSGSAPRDEIPCHSDILPTGPQCVESSSVINGQQEKSSHFTKLPSELSKSPSDELTQCGEPEPSQTADHSFRDHRQGSEEEHSPVLKTLERRAARKLPSKSLEDIPSDSSNQAKVDNLPEELVRSAEDDQKADQEPDTNECIPGISTVPSLPDNQFSHPDKLKRMSKSVPAFLQDESDDRETDTASESSYQLRRYKKSPSSLTNLSSSSGMTSLSSASGSVMSVYSGDFGNLEVKGSVQFALDYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKTYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIERQFLKTQKLNLSVWHRDTFKRNSFLGEVELDLETWDWDSKQNKQLKWYPLKRKTAPVALETENRGEMKLALQYVPEPSPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPVFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWVEATLPLRMLLIAKLSK
uniprot
proteins
function
FUNCTION: Isoform 11 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. Required for cytotoxic granule docking at the immunologic synapse. Isoform 1 may play a role in melanosome transport and vesicle trafficking. It controls melanosome distribution in the cell periphery and regulates melanocyte morphology. Isoform 1 acts as a positive mediator of mucus secretion by the surface mucus cells of the stomach. Mediates basal mucus secretion by gastric surface cells by promoting the proper granule biognesis and docking of mucus granules with the apical plasma membrane. {ECO:0000269|PubMed:15543135, ECO:0000269|PubMed:16716193, ECO:0000269|PubMed:18266782}.
uniprot
proteins
mass_dalton
106806
uniprot
proteins
mutagenesis
MUTAGEN 698; /note="K->Q: Loss of membrane localization; when associated with Q-699; Q-700; Q-705 and Q-706."; /evidence="ECO:0000269|PubMed:15543135"; MUTAGEN 699; /note="K->Q: Loss of membrane localization; when associated with Q-698; Q-700; Q-705 and Q-706."; /evidence="ECO:0000269|PubMed:15543135"; MUTAGEN 700; /note="K->Q: Loss of membrane localization; when associated with Q-698; Q-699; Q-705 and Q-706."; /evidence="ECO:0000269|PubMed:15543135"; MUTAGEN 705; /note="K->Q: Loss of membrane localization; when associated with Q-698; Q-699; Q-700 and Q-706."; /evidence="ECO:0000269|PubMed:15543135"; MUTAGEN 706; /note="K->Q: Loss of membrane localization; when associated with Q-698; Q-699; Q-700 and Q-705."; /evidence="ECO:0000269|PubMed:15543135
uniprot
proteins
post_translational_modification
PTM: Isoform 1 is highly susceptible to proteolytic degradation and is stabilized by the interaction with RAB27A.
uniprot
proteins
pubmed
11243866
uniprot
proteins
pubmed
11327731
uniprot
proteins
pubmed
11773082
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15543135
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16376427
uniprot
proteins
pubmed
16716193
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
17182843
uniprot
proteins
pubmed
18266782
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
950
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Melanosome membrane {ECO:0000269|PubMed:15543135}; Peripheral membrane protein {ECO:0000269|PubMed:15543135}. Note=Bound to melanosomes. Isoform 1 is localized mainly on peripheral melanosomes but not on less mature melanosomes around the nucleus. {ECO:0000269|PubMed:15543135}.; SUBCELLULAR LOCATION: [Isoform 11]: Cell membrane {ECO:0000269|PubMed:11243866, ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782}. Note=In the pancreatic alpha cells distributed in both peripheral and anterior regions. Localizes on the glucagon granules in the cell periphery. {ECO:0000269|PubMed:17182843}.
uniprot
proteins