Trim3
entrez
55992
canonical
uniprot
Q9R1R2
canonical
ensembl
ENSMUSG00000036989
resolver
ensp
ENSMUSP00000053384
resolver
ensp
ENSMUSP00000102401
resolver
ensp
ENSMUSP00000102403
resolver
ensp
ENSMUSP00000114822
resolver
ensp
ENSMUSP00000245210
resolver
ensp
ENSMUSP00000245213
resolver
enst
ENSMUST00000057525
resolver
enst
ENSMUST00000106789
resolver
enst
ENSMUST00000106791
resolver
enst
ENSMUST00000147044
resolver
genesymbol
Trim3
resolver
genesymbol_syn
Hac1
resolver
genesymbol_syn
Rnf22
resolver
uniprot
F6YMC8
resolver
uniprot
Q3TDT0
resolver
uniprot
Q3UMU5
resolver
uniprot_entry
F6YMC8_MOUSE
resolver
uniprot_entry
Q3TDT0_MOUSE
resolver
uniprot_entry
TRIM3_MOUSE
resolver
uniprot_sec
Q3UMU5
resolver
amino_acid_sequence
MAKREDSPGPEVQPMDKQFLVCSICLDRYRCPKVLPCLHTFCERCLQNYIPPQSLTLSCPVCRQTSILPEQGVSALQNNFFISSLMEAMQQAPEGAHDPEDPHPLSAVAGRPLSCPNHEGKTMEFYCEACETAMCGECRAGEHREHGTVLLRDVVEQHKAALQRQLEAVRGRLPQLSAAIALVGGISQQLQERKAEALAQISAAFEDLEQALQQRKQALVSDLESICGAKQKVLQTQLDTLRQGQEHIGSSCSFAEQALRLGSAPEVLLVRKHMRERLAALAAQAFPERPHENAQLELVLEVDGLRRSVLNLGALLTTSATAHETVATGEGLRQALVGQPASLTVTTKDKDGRLVRTGSAELCAEITGPDGVRLAVPVVDHKNGTYELVYTARTEGDLLLSVLLYGQPVRGSPFRVRALRPGDLPPSPDDVKRRVKSPGGPGSHVRQKAVRRPSSMYSTGGKRKDNPIEDELVFRVGSRGREKGEFTNLQGVSAASSGRIVVADSNNQCIQVFSNEGQFKFRFGVRGRSPGQLQRPTGVAVDTNGDIIVADYDNRWVSIFSPEGKFKTKIGAGRLMGPKGVAVDRNGHIIVVDNKSCCVFTFQPNGKLVGRFGGRGATDRHFAGPHFVAVNNKNEIVVTDFHNHSVKVYSADGEFLFKFGSHGEGNGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDSSGSFLSYINTSAEPLYGPQGLALTSDGHVVVADAGNHCFKAYRYLQ
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase that plays essential roles in neuronal functions such as regulation of neuronal plasticity, learning, and memory (PubMed:24086586, PubMed:26527743). In addition to its neuronal functions, participates in other biological processes such as innate immunity or cell cycle regulation (By similarity). Component of the cytoskeleton-associated recycling or transport complex in neurons, polyubiquitinates gamma-actin, thus regulating neuronal plasticity, learning, and memory (PubMed:26527743). Ubiquitinates postsynaptic scaffold GKAP, a neuronal substrate involved in synaptic remodeling and thereby modulates dendritic spine morphology (By similarity). Positively regulates motility of microtubule-dependent motor protein KIF21B (PubMed:24086586). Induces growth arrest via its RING-dependent E3 ligase activity and ubiquitinates CDKN1A. Positively regulates TLR3-mediated signaling by mediating 'Lys-63'-linked polyubiquitination of TLR3 (PubMed:26527743). In turn, promotes the recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes (By similarity). {ECO:0000250|UniProtKB:O70277, ECO:0000250|UniProtKB:O75382, ECO:0000269|PubMed:24086586, ECO:0000269|PubMed:26527743, ECO:0000269|PubMed:32878999}.
uniprot
proteins
mass_dalton
80774
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
11331580
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24086586
uniprot
proteins
pubmed
26527743
uniprot
proteins
pubmed
32878999
uniprot
proteins
sequence_length
744
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O75382}. Early endosome {ECO:0000250|UniProtKB:O75382}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:24086586}. Cell projection, dendrite {ECO:0000269|PubMed:24086586}. Note=Mainly located in the Golgi apparatus and transported to the early endosomes upon stimulation with dsRNA. {ECO:0000250|UniProtKB:O75382}.
uniprot
proteins