Trim71
entrez
636931
canonical
uniprot
Q1PSW8
canonical
ensembl
ENSMUSG00000079259
resolver
ensp
ENSMUSP00000107447
resolver
enst
ENSMUST00000111816
resolver
genesymbol
Trim71
resolver
genesymbol_syn
Gm1127
resolver
genesymbol_syn
Lin41
resolver
uniprot_entry
LIN41_MOUSE
resolver
amino_acid_sequence
MASFPETDFQICLLCKEMCGSPAPLSSNSSASSSSSQTSTSSAGGGGPGAAARRLHVLPCLHAFCRPCLEAHRLPAPGGAGPAEALKLRCPVCDQKVVLAEAAGMDALPSSAFLLSNLLDAVVATAEEPPPKNGRAGGGPGGAGGHSNHRHHAHHPAQRAAAPAPQPPPGPAASPGSLLMRRPHGCSSCDEGNAASSRCLDCQEHLCDNCVRAHQRVRLTKDHYIERGPPGPAAASAAQQLGLGPPFAGAPFSILSVFPERLGFCQHHDDEVLHLYCDTCSVPICRECTLGRHGGHSFAYLQDALQDSRALTIQLLADAQQGRQALQLSIEQAQTVAEQVEMKAKVVQSEVKAVTARHKKALEDRECELLWKVEKIRQVKAKSLFLQVEKLRQSLSKLESTISAVQQVLEEGRALDILLARDRMLAQVQELKTIRGLLQPQEDDRIMFTPPDQALYLALKSIGFVSSGAFAPLTKATGDGIKRALQGKVASFTVMGYDHDGEPRHSGGDLMSVVVLGPDGNLFGAEVSDQQNGTYIVSYRPQLEGEHLVSVTLYNQHIENSPFKVVVKSGRSYVGIGLPGLSFGSEGDGEGKLCRPWGVSVDKEGFIIVADRSNNRIQVFKPCGSFHHKFGTLGSRPGQFDRPAGVACDASRRIIVADKDNHRIQIFTFEGQFLLKFGEKGTKNGQFNYPWDVAVNSEGKILVSDTRNHRIQLFGPDGVFLNKYGFEGSLWKHFDSPRGVAFNNEGHLVVTDFNNHRLLVIHPDCQSARFLGSEGSGNGQFLRPQGVAVDQEGRIIVADSRNHRVQMFEANGSFLCKFGAQGSGFGQMDRPSGIAVTPDGLIVVVDFGNNRILIF
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance (PubMed:19898466). Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression (PubMed:22735451). In addition, participates in post-transcriptional mRNA repression in a miRNA independent mechanism (PubMed:23125361). Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (PubMed:22735451). Specific regulator of miRNA biogenesis. miRNA Binds MIR29A hairpin and postranscriptionally modulates MIR29A levels, which indirectly regulates TET proteins expression (By similarity). {ECO:0000250|UniProtKB:Q2Q1W2, ECO:0000269|PubMed:19898466, ECO:0000269|PubMed:22735451, ECO:0000269|PubMed:23125361}.
uniprot
proteins
mass_dalton
92054
uniprot
proteins
mutagenesis
MUTAGEN 12; /note="C->L: Abolishes E3 ubiquitin-protein ligase activity; when associated with A-15."; /evidence="ECO:0000269|PubMed:19898466"; MUTAGEN 15; /note="C->A: Abolishes E3 ubiquitin-protein ligase activity; when associated with L-12."; /evidence="ECO:0000269|PubMed:19898466
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. {ECO:0000269|PubMed:22508726}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
16245339
uniprot
proteins
pubmed
16247770
uniprot
proteins
pubmed
16477647
uniprot
proteins
pubmed
19098426
uniprot
proteins
pubmed
19898466
uniprot
proteins
pubmed
22508726
uniprot
proteins
pubmed
22735451
uniprot
proteins
pubmed
23125361
uniprot
proteins
pubmed
25883935
uniprot
proteins
sequence_length
855
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, P-body {ECO:0000269|PubMed:19898466, ECO:0000269|PubMed:22508726, ECO:0000269|PubMed:22735451}.
uniprot
proteins