Nmral1
entrez
67824
canonical
uniprot
Q8K2T1
canonical
ensembl
ENSMUSG00000063445
resolver
ensp
ENSMUSP00000074500
resolver
ensp
ENSMUSP00000078132
resolver
ensp
ENSMUSP00000111517
resolver
ensp
ENSMUSP00000112754
resolver
enst
ENSMUST00000115851
resolver
enst
ENSMUST00000120056
resolver
genesymbol
Nmral1
resolver
uniprot
D3YU12
resolver
uniprot
G5E8S7
resolver
uniprot
Q8BVF0
resolver
uniprot
Q9CZP2
resolver
uniprot_entry
D3YU12_MOUSE
resolver
uniprot_entry
G5E8S7_MOUSE
resolver
uniprot_entry
NMRL1_MOUSE
resolver
uniprot_sec
Q8BVF0
resolver
uniprot_sec
Q9CZP2
resolver
amino_acid_sequence
MADRKLVVVFGATGAQGGSVARALLEDGTFRIRVVTRNPEQRAAKELKQQGAEVVRGDQDDAASMELALAGAHATFIVTNYWETCSQDREVQQPHQWDQVFKQGKLLADLAKRLGLHYVVYSGLENIRKLTAGKLAAGHFDGKGEVEEYFRDIGVPMTSVRLPCYFENLLSYFLPQKAADGKSFLLDLPMGDVPMDGMSVSDLGPVVLSLLKKPEEYVGQNIGLSTCRHTAEEYAALLSKHTGKAVHHAKTTPEDYEKLGFQGAQDLANMFRFYTLKPDRNIHLTLRLNPKAQTLDQWLEQHKGDFAQL
uniprot
proteins
function
FUNCTION: Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsequently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
34376
uniprot
proteins
protein_family
NmrA-type oxidoreductase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
309
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Under normal redox growth conditions localizes in the cytoplasm and perinuclear region. Nuclear localization is promoted by increased intracellular nitric oxide and reduced NADPH/NADP(+) ratios (By similarity). {ECO:0000250}.
uniprot
proteins