Spag4
entrez
245865
canonical
uniprot
Q9JJF2
canonical
ensembl
ENSMUSG00000038180
resolver
ensp
ENSMUSP00000036484
resolver
genesymbol
Spag4
resolver
uniprot
A3KGK4
resolver
uniprot
Q8BLQ4
resolver
uniprot_entry
Q8BLQ4_MOUSE
resolver
uniprot_entry
SPAG4_MOUSE
resolver
uniprot_sec
A3KGK4
resolver
amino_acid_sequence
MRRSPRSGSAASSHNHTPNFYSENSNSSHSATSGDSNGRRSAGPELGEPEGRRARGSSCGEPALSPGMPGGDTWAGSSRPKLAPRSHNGQTACGAATVRGGASEPSGSSVVLEEQLNLLPILDLRQEMPTPRVSKSFLSLLFQVLSMVLSLAVDGLVCVCREICSIRFLFTAVSLLSIFLAALWWGLLYLIPPLENEPTEMLTLSQYHHRVHSQGQQLQQLQAELNKLHKEVSSVRAAHSERVAKLVFQRLNEDFVRKPDYALSSVGASIDLEKTSSDYEDQNTAYFWNRLSFWNYARPPSVILEPDVFPGNCWAFEGDKGQVVIRLPGHVQLSDITLQHPPPTVAHTGGASSAPRDFAVYGLQADDETEVFLGKFIFDVQKSEIQTFHLQNDPPSAFPKVKIQILSNWGHPRFTCLYRVRAHGVRTSEWADDNATGVTGGPH
uniprot
proteins
function
FUNCTION: Involved in spermatogenesis. Required for sperm head formation but not required to establish and maintain general polarity of the sperm head. Required for anchoring and organization of the manchette. Required for targeting of SUN3 and probably SYNE1 through a probable SUN1:SYNE3 LINC complex to the nuclear envelope and involved in accurate posterior sperm head localization of the complex. May anchor SUN3 the nuclear envelope. Involved in maintenance of the nuclear envelope integrity. May assist the organization and assembly of outer dense fibers (ODFs), a specific structure of the sperm tail. {ECO:0000269|PubMed:26621829}.
uniprot
proteins
mass_dalton
48582
uniprot
proteins
pubmed
10373309
uniprot
proteins
pubmed
11042159
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26621829
uniprot
proteins
pubmed
38870534
uniprot
proteins
sequence_length
443
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Expressed at the manchette between steps 9 and 12 of spermiogenesis, then localized to the posterior of the nucleus following manchette detachment from step 13 onwards (at protein level). {ECO:0000269|PubMed:38870534}.; SUBCELLULAR LOCATION: [Isoform 1]: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O55034}. Nucleus envelope {ECO:0000269|PubMed:26621829}. Nucleus inner membrane {ECO:0000305}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:O55034}. Note=In spermatids, localized in the transient manchette and in the axoneme of elongating spermatids and epididymal sperm (By similarity). Conflictingly is not found in axoneme but only associated with the manchette where cytoplasmic microtubules contact the nuclear envelope. Localizes at the posterior lateral side of round and elongating spermatids (PubMed:26621829). {ECO:0000250|UniProtKB:O55034, ECO:0000269|PubMed:26621829}.
uniprot
proteins
transmembrane_region
TRANSMEM 137..157; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 168..188; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins