Slc18a1
entrez
110877
canonical
uniprot
Q8R090
canonical
ensembl
ENSMUSG00000036330
resolver
ensp
ENSMUSP00000046924
resolver
ensp
ENSMUSP00000185663
resolver
enst
ENSMUST00000037478
resolver
genesymbol
Slc18a1
resolver
genesymbol_syn
Vmat1
resolver
uniprot
Q32XG7
resolver
uniprot_entry
Q32XG7_MOUSE
resolver
uniprot_entry
VMAT1_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by reserpine, and the proton ionophore carbonyl cyanide-p-trifluoromethoxyphenylhydrazone (FCCP). {ECO:0000269|PubMed:21712771}.
uniprot
proteins
amino_acid_sequence
MFQVVLGAPQRLLKEGRQSRKLVLVVVFVALLLDNMLLTVVVPIVPTFLYATEFKDINSSLLRGPSVSSQQALTSPAFSTTFSFFDNTTMTVEEHVPFRVAWINGTIPPPVTEAGSVPKNNCLQGIEFLEEENVRIGILFASKALMQLLVNPFVGPLTNRIGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASVYTDNYERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQFCILWPSKVSPESAMGTPLLTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQLGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVGISLLCVPLAHNIFGLIGPNAGLGFAIGMVDSSLMPIMGYLVDLRHTSVYGSVYAIADVAFCVGFAIGPSTGGVIVPVIGFPWLMVIIGTINIIYAPLCCFLQNPPAKEEELAILNQECPTETQMYTIQRPTKEFPLGENSDDPGSEE
uniprot
proteins
function
FUNCTION: Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports catecholamines and indolamines with higher affinity for serotonin (PubMed:21712771). Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates presynaptic monoaminergic vesicle transport in the amygdala and prefrontal brain regions related with emotion processing in response to environmental stimuli (By similarity). {ECO:0000250|UniProtKB:P54219, ECO:0000269|PubMed:21712771}.
uniprot
proteins
mass_dalton
56033
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Vesicular transporter family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21712771
uniprot
proteins
pubmed
23201251
uniprot
proteins
sequence_length
521
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:P54219}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000305|PubMed:23201251}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 136..155; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 165..185; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 195..215; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 225..247; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 254..276; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 297..316; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 333..357; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 363..383; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 395..415; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 420..440; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 446..467; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins