SETD6
entrez
79918
canonical
uniprot
Q8TBK2
canonical
ensembl
ENSG00000103037
resolver
ensp
ENSP00000219315
resolver
ensp
ENSP00000310082
resolver
ensp
ENSP00000412858
resolver
ensp
ENSP00000735045
resolver
ensp
ENSP00000735048
resolver
genesymbol
SETD6
resolver
hgnc
HGNC:26116
resolver
uniprot
A8K380
resolver
uniprot
B5ME38
resolver
uniprot
Q9H787
resolver
uniprot_entry
SETD6_HUMAN
resolver
uniprot_sec
A8K380
resolver
uniprot_sec
B5ME38
resolver
uniprot_sec
Q9H787
resolver
activity_regulation
ACTIVITY REGULATION: Activated by automethylation. {ECO:0000269|PubMed:30189201}.
uniprot
proteins
amino_acid_sequence
MATQAKRPRVAGPVDGGDLDPVACFLSWCRRVGLELSPKVSERAGGRRTRGGARAALTSPPAQVAVSRQGTVAGYGMVARESVQAGELLFVVPRAALLSQHTCSIGGLLERERVALQSQSGWVPLLLALLHELQAPASRWRPYFALWPELGRLEHPMFWPEEERRCLLQGTGVPEAVEKDLANIRSEYQSIVLPFMEAHPDLFSLRVRSLELYHQLVALVMAYSFQEPLEEEEDEKEPNSPVMVPAADILNHLANHNANLEYSANCLRMVATQPIPKGHEIFNTYGQMANWQLIHMYGFVEPYPDNTDDTADIQMVTVREAALQGTKTEAERHLVYERWDFLCKLEMVGEEGAFVIGREEVLTEEELTTTLKVLCMPAEEFRELKDQDGGGDDKREEGSLTITNIPKLKASWRQLLQNSVLLTLQTYATDLKTDQGLLSNKEVYAKLSWREQQALQVRYGQKMILHQLLELTS
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulation of NF-kappa-B transcription factor activity (PubMed:21131967, PubMed:21515635, PubMed:30189201). Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) (PubMed:23324626). Required for the maintenance of embryonic stem cell self-renewal (By similarity). Methylates PAK4. {ECO:0000250|UniProtKB:Q9CWY3, ECO:0000269|PubMed:21131967, ECO:0000269|PubMed:21515635, ECO:0000269|PubMed:23324626, ECO:0000269|PubMed:30189201}.
uniprot
proteins
mass_dalton
53189
uniprot
proteins
mutagenesis
MUTAGEN 39; /note="K->R: Greatly decreases automethylation. Impairs the methyltransferase activity toward RELA and PAK4; when associated with Arg-179."; /evidence="ECO:0000269|PubMed:30189201"; MUTAGEN 179; /note="K->R: Abolishes automethylation. Impairs the methyltransferase activity toward RELA and PAK4; when associated with Arg-39."; /evidence="ECO:0000269|PubMed:30189201"; MUTAGEN 283; /note="N->A: Impairs the methyltransferase activity toward RELA."; /evidence="ECO:0000269|PubMed:21515635"; MUTAGEN 283; /note="N->F: Decreases the methyltransferase activity toward RELA."; /evidence="ECO:0000269|PubMed:21515635"; MUTAGEN 285; /note="Y->A: Abolishes methyltransferase activity. Greatly decreases the stability of monomeric, homodimeric and homotrimeric structures."; /evidence="ECO:0000269|PubMed:21131967, ECO:0000269|PubMed:30189201"; MUTAGEN 372; /note="K->R: Has little effect on automethylation level."; /evidence="ECO:0000269|PubMed:30189201
uniprot
proteins
post_translational_modification
PTM: Automethylated; Lys-39 and Lys-179 serve as the major automethylation sites. {ECO:0000269|PubMed:30189201}.
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
Histone-lysine methyltransferase family
uniprot
proteins
protein_family
SETD6 subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
21131967
uniprot
proteins
pubmed
21515635
uniprot
proteins
pubmed
23324626
uniprot
proteins
pubmed
30189201
uniprot
proteins
sequence_length
473
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21131967}.
uniprot
proteins