Itm2c
entrez
301575
canonical
uniprot
Q5PQL7
canonical
ensembl
ENSRNOG00000017359
resolver
ensembl
ENSRNOG00055007625
resolver
ensembl
ENSRNOG00060007985
resolver
ensp
ENSRNOP00000108705
resolver
ensp
ENSRNOP00055010182
resolver
ensp
ENSRNOP00060009970
resolver
enst
ENSRNOT00000161256
resolver
enst
ENSRNOT00055012765
resolver
enst
ENSRNOT00060013150
resolver
genesymbol
Itm2c
resolver
uniprot_entry
ITM2C_RAT
resolver
amino_acid_sequence
MVKISFQPAVAGVKAEKADKAAASGPASASAPAAEILLTPAREERPPRHRSRKGGSVGGVCYLSMGMVVLLMGLVFASVYIYRYFFLAQLARDNFFHCGVLYEDSLSSQIRTRLELEEDVKIYLEENYERINVPVPQFGGGDPADIIHDFQRGLTAYHDISLDKCYVIELNTTIVLPPRNFWELLMNVKRGTYLPQTYIIQEEMVVTEHVRDKEALGSFIYHLCNGKDTYRLRRRATRRRINKRGAKNCNAIRHFENTFVVETLICGVV
uniprot
proteins
function
FUNCTION: Negative regulator of amyloid-beta peptide production. May inhibit the processing of APP by blocking its access to alpha- and beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal fragment is negligible, suggesting that ITM2C is a poor gamma-secretase cleavage inhibitor. May play a role in TNF-induced cell death and neuronal differentiation (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
30480
uniprot
proteins
post_translational_modification
PTM: Type I membrane-bound, as well as soluble, furin has a pre-eminent role in ITM2C proteolytic processing. PCSK7 and PCSK5 may also be involved although to a lesser extent. The soluble form of PCSK7 is incapable of processing ITM2C. Fails to undergo shedding by ADAM10 and intramembrane cleavage by SPPL2B (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
ITM2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
269
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 57..77; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins