PHOSPHO1
entrez
162466
canonical
uniprot
Q8TCT1
canonical
ensembl
ENSG00000173868
resolver
ensp
ENSP00000311925
resolver
ensp
ENSP00000406909
resolver
genesymbol
PHOSPHO1
resolver
hgnc
HGNC:16815
resolver
uniprot
E9PAM0
resolver
uniprot
Q17RU6
resolver
uniprot_entry
PHOP1_HUMAN
resolver
uniprot_sec
E9PAM0
resolver
uniprot_sec
Q17RU6
resolver
amino_acid_sequence
MSGCFPVSGLRCLSRDGRMAAQGAPRFLLTFDFDETIVDENSDDSIVRAAPGQRLPESLRATYREGFYNEYMQRVFKYLGEQGVRPRDLSAIYEAIPLSPGMSDLLQFVAKQGACFEVILISDANTFGVESSLRAAGHHSLFRRILSNPSGPDARGLLALRPFHTHSCARCPANMCKHKVLSDYLRERAHDGVHFERLFYVGDGANDFCPMGLLAGGDVAFPRRGYPMHRLIQEAQKAEPSSFRASVVPWETAADVRLHLQQVLKSC
uniprot
proteins
ec_number
3.1.3.75
uniprot
proteins
function
FUNCTION: Phosphatase that has a high activity toward phosphoethanolamine (PEA) and phosphocholine (PCho) (PubMed:15175005). Involved in the generation of inorganic phosphate for bone mineralization (By similarity). Acts in a non-redundant manner with PHOSPHO1 in skeletal mineralization: while PHOSPHO1 mediates the initiation of hydroxyapatite crystallization in the matrix vesicles (MVs), ALPL/TNAP catalyzes the spread of hydroxyapatite crystallization in the extracellular matrix (By similarity). {ECO:0000250|UniProtKB:Q8R2H9, ECO:0000269|PubMed:15175005}.
uniprot
proteins
mass_dalton
29713
uniprot
proteins
mutagenesis
MUTAGEN 32; /note="D->N: Abolishes phosphatase activity."; /evidence="ECO:0000269|PubMed:16054448"; MUTAGEN 43; /note="D->N: Strongly reduces reactivity toward PEA and PCho substrates. Abolishes phosphatase activity; when associated with N-123."; /evidence="ECO:0000269|PubMed:16054448"; MUTAGEN 123; /note="D->N: Strongly reduces reactivity toward PEA and PCho substrates. Abolishes phosphatase activity; when associated with N-43."; /evidence="ECO:0000269|PubMed:16054448"; MUTAGEN 203; /note="D->S: Abolishes phosphatase activity."; /evidence="ECO:0000269|PubMed:16054448
uniprot
proteins
protein_family
HAD-like hydrolase superfamily
uniprot
proteins
protein_family
PHOSPHO family
uniprot
proteins
pubmed
12464021
uniprot
proteins
pubmed
14983068
uniprot
proteins
pubmed
15050893
uniprot
proteins
pubmed
15175005
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16054448
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
18471996
uniprot
proteins
sequence_length
267
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Extracellular vesicle {ECO:0000250|UniProtKB:Q8R2H9}. Note=Localizes to special class of extracellular vesicles, named matrix vesicles (MVs), which are released by osteogenic cells. {ECO:0000250|UniProtKB:Q8R2H9}.
uniprot
proteins