TCL1A
entrez
8115
canonical
uniprot
P56279
canonical
ensembl
ENSG00000100721
resolver
ensp
ENSP00000385036
resolver
ensp
ENSP00000450496
resolver
ensp
ENSP00000450701
resolver
ensp
ENSP00000451506
resolver
enst
ENST00000402399
resolver
enst
ENST00000554012
resolver
enst
ENST00000555202
resolver
enst
ENST00000556450
resolver
genesymbol
TCL1A
resolver
genesymbol_syn
TCL1
resolver
hgnc
HGNC:11648
resolver
uniprot
Q6IBK7
resolver
uniprot_entry
TCL1A_HUMAN
resolver
uniprot_sec
Q6IBK7
resolver
amino_acid_sequence
MAECPTLGEAVTDHPDRLWAWEKFVYLDEKQHAWLPLTIEIKDRLQLRVLLRREDVVLGRPMTPTQIGPSLLPIMWQLYPDGRYRSSDSSFWRLVYHIKIDGVEDMLLELLPDD
uniprot
proteins
disease_involvement
DISEASE: Note=Chromosomal aberrations activating TCL1A are found in chronic T-cell leukemias (T-CLL). Translocation t(14;14)(q11;q32); translocation t(7;14)(q35;q32); inversion inv(14)(q11;q32) that involves the T-cell receptor alpha/delta loci.
uniprot
proteins
function
FUNCTION: Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. {ECO:0000269|PubMed:10716693, ECO:0000269|PubMed:10983986, ECO:0000269|PubMed:11707444, ECO:0000269|PubMed:11839817}.
uniprot
proteins
mass_dalton
13460
uniprot
proteins
mutagenesis
MUTAGEN 16; /note="D->G: Greatly reduced binding to AKT1, AKT2 and AKT3. Abolishes nuclear transport of AKT1."; /evidence="ECO:0000269|PubMed:11839817"; MUTAGEN 30; /note="K->M: Slightly reduced binding to AKT2."; /evidence="ECO:0000269|PubMed:11839817"; MUTAGEN 36..38; /note="PLT->AAA: Unable to homodimerize but has no effect on interaction with AKT1, AKT2 or AKT3."; /evidence="ECO:0000269|PubMed:11839817"; MUTAGEN 46; /note="Q->R: Slightly increased binding to AKT2."; /evidence="ECO:0000269|PubMed:11839817"; MUTAGEN 74; /note="I->V: Greatly reduced binding to AKT2. Abolishes nuclear transport of AKT1."; /evidence="ECO:0000269|PubMed:11839817"; MUTAGEN 106; /note="M->V: Slightly increased binding to AKT2."; /evidence="ECO:0000269|PubMed:11839817
uniprot
proteins
protein_family
TCL1 family
uniprot
proteins
pubmed
10716693
uniprot
proteins
pubmed
10983986
uniprot
proteins
pubmed
11707444
uniprot
proteins
pubmed
11839817
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16934922
uniprot
proteins
pubmed
7809072
uniprot
proteins
pubmed
7987816
uniprot
proteins
pubmed
9519406
uniprot
proteins
sequence_length
114
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Microsome {ECO:0000269|PubMed:7987816}. Endoplasmic reticulum {ECO:0000269|PubMed:7987816}. Note=Microsomal fraction.
uniprot
proteins