LMBR1L
entrez
55716
canonical
uniprot
Q6UX01
canonical
ensembl
ENSG00000139636
resolver
ensp
ENSP00000267102
resolver
ensp
ENSP00000447329
resolver
ensp
ENSP00000562122
resolver
ensp
ENSP00000653724
resolver
ensp
ENSP00000705500
resolver
genesymbol
LMBR1L
resolver
genesymbol_syn
KIAA1174
resolver
genesymbol_syn
LIMR
resolver
hgnc
HGNC:18268
resolver
uniprot
A0A024R0Y9
resolver
uniprot
A0A0S2Z6E3
resolver
uniprot
Q969J4
resolver
uniprot
Q96BY8
resolver
uniprot
Q96HN8
resolver
uniprot
Q9NT09
resolver
uniprot
Q9NVE1
resolver
uniprot
Q9NVU9
resolver
uniprot
Q9ULP6
resolver
uniprot_entry
A0A024R0Y9_HUMAN
resolver
uniprot_entry
A0A0S2Z6E3_HUMAN
resolver
uniprot_entry
LMBRL_HUMAN
resolver
uniprot_sec
Q969J4
resolver
uniprot_sec
Q96BY8
resolver
uniprot_sec
Q96HN8
resolver
uniprot_sec
Q9NT09
resolver
uniprot_sec
Q9NVE1
resolver
uniprot_sec
Q9NVU9
resolver
uniprot_sec
Q9ULP6
resolver
amino_acid_sequence
MEAPDYEVLSVREQLFHERIRECIISTLLFATLYILCHIFLTRFKKPAEFTTVDDEDATVNKIALELCTFTLAIALGAVLLLPFSIISNEVLLSLPRNYYIQWLNGSLIHGLWNLVFLFSNLSLIFLMPFAYFFTESEGFAGSRKGVLGRVYETVVMLMLLTLLVLGMVWVASAIVDKNKANRESLYDFWEYYLPYLYSCISFLGVLLLLVCTPLGLARMFSVTGKLLVKPRLLEDLEEQLYCSAFEEAALTRRICNPTSCWLPLDMELLHRQVLALQTQRVLLEKRRKASAWQRNLGYPLAMLCLLVLTGLSVLIVAIHILELLIDEAAMPRGMQGTSLGQVSFSKLGSFGAVIQVVLIFYLMVSSVVGFYSSPLFRSLRPRWHDTAMTQIIGNCVCLLVLSSALPVFSRTLGLTRFDLLGDFGRFNWLGNFYIVFLYNAAFAGLTTLCLVKTFTAAVRAELIRAFGLDRLPLPVSGFPQASRKTQHQ
uniprot
proteins
function
FUNCTION: Plays an essential role in lymphocyte development by negatively regulating the canonical Wnt signaling pathway (By similarity). In association with UBAC2 and E3 ubiquitin-protein ligase AMFR, promotes the ubiquitin-mediated degradation of CTNNB1 and Wnt receptors FZD6 and LRP6 (By similarity). LMBR1L stabilizes the beta-catenin destruction complex that is required for regulating CTNNB1 levels (By similarity). Acts as a LCN1 receptor and can mediate its endocytosis (PubMed:11287427, PubMed:12591932, PubMed:23964685). {ECO:0000250|UniProtKB:Q9D1E5, ECO:0000269|PubMed:11287427, ECO:0000269|PubMed:12591932, ECO:0000269|PubMed:23964685}.
uniprot
proteins
mass_dalton
55209
uniprot
proteins
protein_family
LIMR family
uniprot
proteins
pubmed
10574461
uniprot
proteins
pubmed
11287427
uniprot
proteins
pubmed
12591932
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16423471
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
17991420
uniprot
proteins
pubmed
23964685
uniprot
proteins
pubmed
31073040
uniprot
proteins
sequence_length
489
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11287427, ECO:0000269|PubMed:17991420, ECO:0000269|PubMed:31073040}; Multi-pass membrane protein {ECO:0000269|PubMed:11287427}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:31073040}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 67..87; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 115..135; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 155..175; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 197..217; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 306..326; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 351..371; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 389..409; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 432..452; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins