ALKAL1
entrez
389658
canonical
uniprot
Q6UXT8
canonical
ensembl
ENSG00000196711
resolver
ensp
ENSP00000351345
resolver
genesymbol
ALKAL1
resolver
genesymbol_syn
FAM150A
resolver
hgnc
HGNC:33775
resolver
uniprot
B7ZMG9
resolver
uniprot_entry
ALKL1_HUMAN
resolver
uniprot_sec
B7ZMG9
resolver
amino_acid_sequence
MRPLKPGAPLPALFLLALALSPHGAHGRPRGRRGARVTDKEPKPLLFLPAAGAGRTPSGSRSAEIFPRDSNLKDKFIKHFTGPVTFSPECSKHFHRLYYNTRECSTPAYYKRCARLLTRLAVSPLCSQT
uniprot
proteins
function
FUNCTION: Cytokine that acts as a physiological ligand for receptor tyrosine kinase LTK, leading to its activation (PubMed:25331893, PubMed:26418745, PubMed:26630010, PubMed:34646012, PubMed:34819673). Monomeric ALKAL1 binds to LTK, leading to LTK homodimerization and activation (PubMed:34646012, PubMed:34819673). In contrast to ALKAL2, does not act as a potent physiological ligand for ALK (PubMed:26418745, PubMed:34646012). {ECO:0000269|PubMed:25331893, ECO:0000269|PubMed:26418745, ECO:0000269|PubMed:26630010, ECO:0000269|PubMed:34646012, ECO:0000269|PubMed:34819673}.
uniprot
proteins
mass_dalton
14269
uniprot
proteins
mutagenesis
MUTAGEN 76; /note="F->E: Slightly reduced affinity for receptor tyrosine kinase LTK."; /evidence="ECO:0000269|PubMed:34646012"; MUTAGEN 102; /note="R->E: Reduced affinity for receptor tyrosine kinase LTK."; /evidence="ECO:0000269|PubMed:34646012"; MUTAGEN 115; /note="R->E: Reduced affinity for receptor tyrosine kinase LTK."; /evidence="ECO:0000269|PubMed:34646012
uniprot
proteins
protein_family
ALKAL family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
25331893
uniprot
proteins
pubmed
26418745
uniprot
proteins
pubmed
26630010
uniprot
proteins
pubmed
34646012
uniprot
proteins
pubmed
34819673
uniprot
proteins
sequence_length
129
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q6UX46}. Cell membrane {ECO:0000305|PubMed:34646012}. Note=Following interaction with receptor tyrosine kinase LTK, associates with the cell membrane, membrane-binding is required to activate LTK. {ECO:0000250|UniProtKB:Q6UX46}.
uniprot
proteins