Morc2a
entrez
74522
canonical
uniprot
Q69ZX6
canonical
ensembl
ENSMUSG00000034543
resolver
ensp
ENSMUSP00000091087
resolver
ensp
ENSMUSP00000094176
resolver
ensp
ENSMUSP00000185011
resolver
enst
ENSMUST00000093389
resolver
enst
ENSMUST00000096441
resolver
genesymbol
Morc2a
resolver
genesymbol_syn
Kiaa0852
resolver
genesymbol_syn
Zcwcc1
resolver
uniprot
Q5QNQ7
resolver
uniprot
Q6P547
resolver
uniprot
Q6PCN6
resolver
uniprot_entry
MOR2A_MOUSE
resolver
uniprot_entry
Q6PCN6_MOUSE
resolver
uniprot_sec
Q5QNQ7
resolver
uniprot_sec
Q6P547
resolver
activity_regulation
ACTIVITY REGULATION: ATPase activity is dependent of phosphorylation by PAK1 and presence of DNA. {ECO:0000250|UniProtKB:Q9Y6X9}.
uniprot
proteins
amino_acid_sequence
MAFTNYSSLNRAQLTFEYLHTNSTTHEFLFGALAELVDNARDADATRIDIYAERREDLRGGFMLCFLDDGAGMDPSDAASVIQFGKSAKRTPESTQIGQYGNGLKSGSMRIGKDFILFTKKEDTMTCLFLSRTFHEEEGIDEVIVPLPTWNARTREPITDNVEKFAIETELVYKYSPFHTEEQVMNQFMKIPGNSGTLVIIFNLKLMDNGEPELDIISNPKDIQMAETSPEGTKPERRSFRAYAAVLYIDPRMRIFIHGHKVQTKRLSCCLYKPRMYKYTSSRFKTRAEQEVKKAEHVARIAEEKAREAESKARTLEVRMGGDLTRDSRVMLRQVQNTAITLRREADVKKRIKDAKQRALKEPKELNFVFGVNIEHRDLDGMFIYNCSRLIKMYEKVGPQLEGGMACGGVVGVVDVPYLVLEPTHNKQDFADAKEYRHLLRAMGEHLAQYWKDIAIAQRGIIKFWDEFGYLSANWNQPPSSELRFKRRRAMEIPTTIQCDLCLKWRTLPFQLSSVETDYPDTWVCSMNPDPEQDRCEASEQKQKVPLGTLKKDPKTQEEKQKQLTEKIRQQQEKLEALQKTTPIRSQADLKKLPLEVTTRPIEEPVRRPQRPRSPPLPAVIKNAPSRPPSIQTPRPSTQLRKTSVISLPKPPTTAARGETSTSRLLQPTEAPRKPANPPIKTVPRPTPPVHTPPLSLIPSSKSLREVPAQKAIKTPVVKKPEPPVKQSVATSGRKRSLAVSDEEEAEEEAEKRRERCKRGKLAVKEEKKEANELSDSAGEDHPAELRKAQKDKGLHVEVRVNREWYTGRVTAVEVGKNAVRWKVKFDYVPTDTTPRDRWVEKGSEDVRLMKPPSPEHQSPDTQQEGGEEEEAMVARQAVALPEPSTSDGLPIEPDTTATSPSHETIDLLVQILRNCLRYFLPPSFPISKKELSVMNSEELISFPLKEYFKQYEVGLQNLCHSYQSRADSRAKASEESLRTSEKKLRETEEKLQKLRTNIVALLQKVQEDIDINTDDELDAYIEDLITKGD
uniprot
proteins
ec_number
3.6.1.-
uniprot
proteins
function
FUNCTION: ATP-dependent chromatin remodeler essential for epigenetic silencing by the HUSH complex. Recruited by HUSH to target site in heterochromatin, the ATPase activity and homodimerization are critical for HUSH-mediated silencing (By similarity). Represses germ cell-related genes and L1 retrotransposons in collaboration with SETDB1 and the HUSH complex, the silencing is dependent of repressive epigenetic modifications, such as H3K9me3 mark (PubMed:29728365). Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression. During DNA damage response, regulates chromatin remodeling through ATP hydrolysis (By similarity). During DNA damage response, may regulate chromatin remodeling through ATP hydrolysis (By similarity). Together with MPHOSPH8, mediates silencing of protocadherin genes in the nervous system (PubMed:36332029). {ECO:0000250|UniProtKB:Q9Y6X9, ECO:0000269|PubMed:29728365, ECO:0000269|PubMed:36332029}.
uniprot
proteins
mass_dalton
117330
uniprot
proteins
mutagenesis
MUTAGEN 68..69; /note="DD->AA: Abolishes repression of germ cell-related genes and L1 retrotransposons."; /evidence="ECO:0000269|PubMed:29728365
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PAK1 at Ser-737 upon DNA damage. Phosphorylation is required for ATPase activity and recruitment to damaged chromatin. {ECO:0000250|UniProtKB:Q9Y6X9}.
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26497905
uniprot
proteins
pubmed
29329290
uniprot
proteins
pubmed
29728365
uniprot
proteins
pubmed
36332029
uniprot
proteins
sequence_length
1030
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29728365}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9Y6X9}. Chromosome {ECO:0000250|UniProtKB:Q9Y6X9}. Nucleus matrix {ECO:0000250|UniProtKB:Q9Y6X9}. Note=Mainly located in the nucleus. Upon phosphorylation at Ser-737, recruited to damaged chromatin. {ECO:0000250|UniProtKB:Q9Y6X9}.
uniprot
proteins