Dgat1
entrez
13350
canonical
uniprot
Q9Z2A7
canonical
ensembl
ENSMUSG00000022555
resolver
ensp
ENSMUSP00000023214
resolver
enst
ENSMUST00000023214
resolver
genesymbol
Dgat1
resolver
genesymbol_syn
Dgat
resolver
uniprot
Q54AA6
resolver
uniprot
Q9D7Q5
resolver
uniprot_entry
DGAT1_MOUSE
resolver
uniprot_entry
Q54AA6_MOUSE
resolver
uniprot_sec
Q9D7Q5
resolver
amino_acid_sequence
MGDRGGAGSSRRRRTGSRVSVQGGSGPKVEEDEVRDAAVSPDLGAGGDAPAPAPAPAHTRDKDGRTSVGDGYWDLRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQVVSLFLKDPYSWPAPCVIIASNIFVVAAFQIEKRLAVGALTEQMGLLLHVVNLATIICFPAAVALLVESITPVGSVFALASYSIMFLKLYSYRDVNLWCRQRRVKAKAVSTGKKVSGAAAQQAVSYPDNLTYRDLYYFIFAPTLCYELNFPRSPRIRKRFLLRRVLEMLFFTQLQVGLIQQWMVPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWFFHSCLNAVAELLQFGDREFYRDWWNAESVTYFWQNWNIPVHKWCIRHFYKPMLRHGSSKWVARTGVFLTSAFFHEYLVSVPLRMFRLWAFTAMMAQVPLAWIVGRFFQGNYGNAAVWVTLIIGQPVAVLMYVHDYYVLNYDAPVGV
uniprot
proteins
ec_number
2.3.1.20
uniprot
proteins
ec_number
2.3.1.76
uniprot
proteins
function
FUNCTION: Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates (PubMed:15834126, PubMed:19028692, PubMed:20876538, PubMed:22493088, PubMed:28420705). Highly expressed in epithelial cells of the small intestine and its activity is essential for the absorption of dietary fats (By similarity). In liver, plays a role in esterifying exogenous fatty acids to glycerol, and is required to synthesize fat for storage (PubMed:15834126). Also present in female mammary glands, where it produces fat in the milk (By similarity). May be involved in VLDL (very low density lipoprotein) assembly (By similarity). In contrast to DGAT2 it is not essential for survival (PubMed:11959864). Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders (PubMed:19028692). Exhibits additional acyltransferase activities, includin acyl CoA:monoacylglycerol acyltransferase (MGAT), wax monoester and wax diester synthases (PubMed:15834126). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705). {ECO:0000250|UniProtKB:O75907, ECO:0000250|UniProtKB:Q8MK44, ECO:0000269|PubMed:11959864, ECO:0000269|PubMed:15834126, ECO:0000269|PubMed:19028692, ECO:0000269|PubMed:20876538, ECO:0000269|PubMed:22493088, ECO:0000269|PubMed:28420705}.
uniprot
proteins
mass_dalton
56790
uniprot
proteins
mutagenesis
MUTAGEN 426; /note="H->A: Impairs the ability to synthesize triacylglycerols, as well as retinyl and wax esters, in an in vitro acyltransferase assay."; /evidence="ECO:0000269|PubMed:20876538
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; glycerolipid metabolism.
uniprot
proteins
protein_family
Membrane-bound acyltransferase family
uniprot
proteins
protein_family
Sterol o-acyltransferase subfamily
uniprot
proteins
pubmed
10802663
uniprot
proteins
pubmed
11956242
uniprot
proteins
pubmed
11959864
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15834126
uniprot
proteins
pubmed
16106050
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19028692
uniprot
proteins
pubmed
20876538
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22493088
uniprot
proteins
pubmed
23066022
uniprot
proteins
pubmed
28420705
uniprot
proteins
pubmed
9789033
uniprot
proteins
sequence_length
498
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:20876538}; Multi-pass membrane protein {ECO:0000269|PubMed:20876538}.
uniprot
proteins
transmembrane_region
TRANSMEM 93..127; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:O75907"; TRANSMEM 140..165; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:O75907"; TRANSMEM 171..193; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:O75907"; TRANSMEM 201..232; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:O75907"; TRANSMEM 285..319; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:O75907"; TRANSMEM 327..364; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:O75907"; TRANSMEM 411..431; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:O75907"; TRANSMEM 440..458; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:O75907"; TRANSMEM 461..492; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:O75907
uniprot
proteins