Clec4e
entrez
450223
canonical
uniprot
Q67EQ1
canonical
ensembl
ENSRNOG00000061394
resolver
ensembl
ENSRNOG00055009490
resolver
ensembl
ENSRNOG00060028204
resolver
ensembl
ENSRNOG00065033485
resolver
ensp
ENSRNOP00000073160
resolver
ensp
ENSRNOP00000096103
resolver
ensp
ENSRNOP00055012891
resolver
ensp
ENSRNOP00060040928
resolver
ensp
ENSRNOP00065047385
resolver
enst
ENSRNOT00000078725
resolver
enst
ENSRNOT00055016057
resolver
enst
ENSRNOT00060049042
resolver
enst
ENSRNOT00065057561
resolver
genesymbol
Clec4e
resolver
genesymbol_syn
Clecsf9
resolver
genesymbol_syn
Mincle
resolver
uniprot
G3V7B4
resolver
uniprot
Q56TZ4
resolver
uniprot_entry
CLC4E_RAT
resolver
uniprot_entry
G3V7B4_RAT
resolver
uniprot_sec
Q56TZ4
resolver
amino_acid_sequence
MNSTKSPASHHTERECFKNSQVLSWTMAGASILFLSVCFITRCVVTYHSFQIYGQKKLQPHKTIKELSCYLEASGSVKNCCPLNWKHFQSSCYFFSTTTLSWLSSLKNCSDMGAHLVVINTWEEQEFLFRTKPRKKEFYIGLTDQVVEGQWRWVDDTPFTESLSFWDAGEPNNIVFVEDCATMRDSSNPRKNWNDVSCFFSMPWICEMPEISPLD
uniprot
proteins
function
FUNCTION: Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of abnormal self and pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs notably include mycobacterial trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid with potent adjuvant immunomodulatory functions. Interacts with signaling adapter Fc receptor gamma chain/FCER1G to form a functional complex in myeloid cells. Binding of mycobacterial trehalose 6,6'-dimycolate (TDM) to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 (Th1) and T-helper 17 (Th17) cell subtypes. Also recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia and mediates macrophage activation. Through recognition of DAMPs released upon nonhomeostatic cell death, enables immune sensing of damaged self and promotes inflammatory cell infiltration into the damaged tissue. {ECO:0000250|UniProtKB:Q9R0Q8}.
uniprot
proteins
mass_dalton
24911
uniprot
proteins
pubmed
15368084
uniprot
proteins
pubmed
23921530
uniprot
proteins
sequence_length
215
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:23921530}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9R0Q8}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:Q9R0Q8}.
uniprot
proteins
transmembrane_region
TRANSMEM 24..46; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins