Ptgdr2
entrez
309212
canonical
uniprot
Q6XKD3
canonical
ensembl
ENSRNOG00000090389
resolver
ensembl
ENSRNOG00055023574
resolver
ensembl
ENSRNOG00060031117
resolver
ensembl
ENSRNOG00065026651
resolver
ensp
ENSRNOP00000066082
resolver
ensp
ENSRNOP00000099592
resolver
ensp
ENSRNOP00000102756
resolver
ensp
ENSRNOP00000104245
resolver
ensp
ENSRNOP00000104794
resolver
ensp
ENSRNOP00055032905
resolver
ensp
ENSRNOP00060044810
resolver
ensp
ENSRNOP00065037734
resolver
enst
ENSRNOT00000054808
resolver
enst
ENSRNOT00000128375
resolver
enst
ENSRNOT00000143171
resolver
enst
ENSRNOT00000153762
resolver
enst
ENSRNOT00000161378
resolver
enst
ENSRNOT00055040506
resolver
enst
ENSRNOT00060054023
resolver
enst
ENSRNOT00065045984
resolver
genesymbol
Ptgdr2
resolver
genesymbol_syn
Crth2
resolver
genesymbol_syn
Gpr44
resolver
uniprot_entry
PD2R2_RAT
resolver
amino_acid_sequence
MANITLKPLCPLLEEMVQLPNHSNSSLRYIDHVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHRVCLMLWALAVLNTVPYFVFRDTIPRRDGRIMCYYNMLLLNPGSDRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLQLHHRGRQRTGRFVRLVAAIVVAFILCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVLTCPDMLHKLRRSLLTVLESVLVEDSDLSTGPGKRCRRRHRRRASSTTTPASTLLLADRFPQLRPARLIGWMRRGSAELPRRVREQSQEKQGSLSCTLD
uniprot
proteins
function
FUNCTION: Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
45316
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
403
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Internalized receptors colocalized with RAB11A. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 35..55; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 72..92; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 105..125; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 148..168; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 210..230; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 246..266; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 285..305; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins