Mixl1
entrez
27217
canonical
uniprot
Q9WUI0
canonical
ensembl
ENSMUSG00000026497
resolver
ensp
ENSMUSP00000027778
resolver
enst
ENSMUST00000027778
resolver
genesymbol
Mixl1
resolver
genesymbol_syn
Mix
resolver
genesymbol_syn
Mml
resolver
uniprot
Q9QZ61
resolver
uniprot_entry
MIXL1_MOUSE
resolver
uniprot_sec
Q9QZ61
resolver
amino_acid_sequence
MAAAGSQQLQFAEGAAFPIFPAAHPGGQLLPAMRPASGLPAAPHDSRAPAATQCFPNRDSSPTAQTPAGLDPPGPSKGSAAPSAPQRRKRTSFSSEQLQLLELVFRQTMYPDIHLRERLAALTLLPESRIQVWFQNRRAKSRRQSGKSFQPLSSRRGVFLHCPAPGTEARCLKPQLPLEADVNHVPDPSMTGGGVCTSGSQSFETYSSLSEDIGSKLDSWEEHIFSALGNF
uniprot
proteins
function
FUNCTION: Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression. {ECO:0000269|PubMed:12117810, ECO:0000269|PubMed:15673572, ECO:0000269|PubMed:16403910, ECO:0000269|PubMed:17060613, ECO:0000269|PubMed:17151016, ECO:0000269|PubMed:17446562}.
uniprot
proteins
mass_dalton
24844
uniprot
proteins
protein_family
Paired homeobox family
uniprot
proteins
pubmed
10495285
uniprot
proteins
pubmed
11084649
uniprot
proteins
pubmed
12095687
uniprot
proteins
pubmed
12117810
uniprot
proteins
pubmed
12619131
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15673572
uniprot
proteins
pubmed
15982639
uniprot
proteins
pubmed
16403910
uniprot
proteins
pubmed
16433620
uniprot
proteins
pubmed
17060613
uniprot
proteins
pubmed
17151016
uniprot
proteins
pubmed
17446562
uniprot
proteins
pubmed
17568773
uniprot
proteins
sequence_length
231
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108, ECO:0000269|PubMed:12619131}.
uniprot
proteins