Apip
entrez
56369
canonical
uniprot
Q9WVQ5
canonical
ensembl
ENSMUSG00000010911
resolver
ensp
ENSMUSP00000011055
resolver
ensp
ENSMUSP00000262798
resolver
enst
ENSMUST00000011055
resolver
genesymbol
Apip
resolver
genesymbol_syn
Mmrp19
resolver
uniprot
Q8BP46
resolver
uniprot_entry
MTNB_MOUSE
resolver
uniprot_sec
Q8BP46
resolver
amino_acid_sequence
MSGCQAQGDCCSRPCGAQDKEHPRFLIPELCKQFYHLGWVTGTGGGISLKHGNEIYIAPSGVQKERIQPEDMFVCDINEQDISGPPASKKLKKSQCTPLFMNAYTMRGAGAVIHTHSKAAVMATLLFPGQEFKITHQEMIKGIRKCTSGGYYRYDDMLVVPIIENTPEEKDLKERMAHAMNEYPDSCAVLVRRHGVYVWGETWEKAKTMCECYDYLFDIAVSMKKMGLDPTQLPVGENGIV
uniprot
proteins
ec_number
4.2.1.109
uniprot
proteins
function
FUNCTION: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. {ECO:0000255|HAMAP-Rule:MF_03116, ECO:0000269|PubMed:15262985, ECO:0000269|PubMed:17086211}.
uniprot
proteins
mass_dalton
26949
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6. {ECO:0000255|HAMAP-Rule:MF_03116}.
uniprot
proteins
protein_family
Aldolase class II family
uniprot
proteins
protein_family
MtnB subfamily
uniprot
proteins
pubmed
15262985
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17086211
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
241
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03116}.
uniprot
proteins