DOK3
entrez
79930
canonical
uniprot
Q7L591
canonical
ensembl
ENSG00000146094
resolver
ensp
ENSP00000325174
resolver
ensp
ENSP00000349727
resolver
ensp
ENSP00000366316
resolver
ensp
ENSP00000421688
resolver
ensp
ENSP00000424726
resolver
ensp
ENSP00000552803
resolver
ensp
ENSP00000552804
resolver
ensp
ENSP00000552805
resolver
ensp
ENSP00000552806
resolver
ensp
ENSP00000552808
resolver
ensp
ENSP00000636028
resolver
ensp
ENSP00000636029
resolver
ensp
ENSP00000700468
resolver
enst
ENST00000357198
resolver
enst
ENST00000501403
resolver
enst
ENST00000510898
resolver
enst
ENST00000882744
resolver
enst
ENST00000882745
resolver
enst
ENST00000882746
resolver
enst
ENST00000965969
resolver
enst
ENST00000965970
resolver
genesymbol
DOK3
resolver
hgnc
HGNC:24583
resolver
uniprot
D6RAM3
resolver
uniprot
D6RAV2
resolver
uniprot
E9PAT0
resolver
uniprot
H7BXS0
resolver
uniprot
Q8N864
resolver
uniprot
Q9BQB3
resolver
uniprot
Q9H666
resolver
uniprot_entry
D6RAM3_HUMAN
resolver
uniprot_entry
DOK3_HUMAN
resolver
uniprot_sec
D6RAV2
resolver
uniprot_sec
E9PAT0
resolver
uniprot_sec
H7BXS0
resolver
uniprot_sec
Q8N864
resolver
uniprot_sec
Q9BQB3
resolver
uniprot_sec
Q9H666
resolver
amino_acid_sequence
MTRGARLRSDARAQLNQLSLDGGTGSGQKGKCEEFPSSLSSVSPGLEAAALLLAVTMDPLETPIKDGILYQQHVKFGKKCWRKVWALLYAGGPSGVARLESWEVRDGGLGAAGDRSAGPGRRGERRVIRLADCVSVLPADGESCPRDTGAFLLTTTERSHLLAAQHRQAWMGPICQLAFPGTGEASSGSTDAQSPKRGLVPMEENSIYSSWQEVGEFPVVVQRTEAATRCQLKGPALLVLGPDAIQLREAKGTQALYSWPYHFLRKFGSDKGVFSFEAGRRCHSGEGLFAFSTPCAPDLCRAVAGAIARQRERLPELTRPQPCPLPRATSLPSLDTPGELREMPPGPEPPTSRKMHLAEPGPQSLPLLLGPEPNDLASGLYASVCKRASGPPGNEHLYENLCVLEASPTLHGGEPEPHEGPGSRSPTTSPIYHNGQDLSWPGPANDSTLEAQYRRLLELDQVEGTGRPDPQAGFKAKLVTLLSRERRKGPAPCDRP
uniprot
proteins
function
FUNCTION: DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate ABL1 function (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
53288
uniprot
proteins
post_translational_modification
PTM: Constitutively tyrosine-phosphorylated. {ECO:0000250}.; PTM: On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL1 kinase (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
DOK family
uniprot
proteins
protein_family
Type A subfamily
uniprot
proteins
pubmed
12595900
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
496
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
uniprot
proteins