C3ar1
entrez
84007
canonical
uniprot
O55197
canonical
ensembl
ENSRNOG00000009211
resolver
ensp
ENSRNOP00000012216
resolver
ensp
ENSRNOP00000094051
resolver
ensp
ENSRNOP00000104182
resolver
ensp
ENSRNOP00000112598
resolver
enst
ENSRNOT00000012216
resolver
enst
ENSRNOT00000106930
resolver
enst
ENSRNOT00000135206
resolver
enst
ENSRNOT00000153946
resolver
genesymbol
C3ar1
resolver
uniprot
G3V759
resolver
uniprot_entry
C3AR_RAT
resolver
uniprot_entry
G3V759_RAT
resolver
amino_acid_sequence
MESFTADTNSTDLHSRPLFKPQDIASMVILSLTCLLGLPGNGLVLWVAGVKMKRTVNTVWFLHLTLADFLCCLSLPFSVAHLILRGHWPYGLFLCKLIPSVIILNMFASVFLLTAISLDRCLMVHKPIWCQNHRSVRTAFAVCGCVWVVTFVMCIPVFVYRDLLVVDDYSVCGYNFDSSRAYDYWDYMYNSHLPEINPPDNSTGHVDDRTAPSSSVPARDLWTATTALQSQTFHTSPEDPFSQDSASQQPHYGGKPPTVLIATIPGGFPVEDHKSNTLNTGAFLSAHTEPSLTASSSPLYAHDFPDDYFDQLMYGNHAWTPQVAITISRLVVGFLVPFFIMITCYSLIVFRMRKTNLTKSRNKTLRVAVAVVTVFFVCWIPYHIVGILLVITDQESALREVVLPWDHMSIALASANSCFNPFLYALLGKDFRKKARQSVKGILEAAFSEELTHSTSCTQDKAPSKRNHMSTDV
uniprot
proteins
function
FUNCTION: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a, stimulating chemotaxis, granule enzyme release and superoxide anion production. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. C3AR1 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G alpha proteins and mediates inhibition of adenylate cyclase. {ECO:0000250|UniProtKB:Q16581}.
uniprot
proteins
mass_dalton
52896
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of the C-terminus by GRK2 or GRK3 promotes association with beta-arrestin (ARRB1), leading to receptor desensitization and negative regulation of G protein-coupled receptor signaling. {ECO:0000250|UniProtKB:Q16581}.; PTM: Among the sulfation sites Tyr-174 is essential for binding of C3a anaphylatoxin. {ECO:0000250|UniProtKB:Q16581}.; PTM: O-glycosylated. {ECO:0000250|UniProtKB:Q16581}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
23940034
uniprot
proteins
pubmed
9464274
uniprot
proteins
sequence_length
473
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q16581}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q16581}.
uniprot
proteins
transmembrane_region
TRANSMEM 24..46; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 58..80; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 97..118; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 140..160; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 330..349; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 367..389; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 407..427; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins