MRLN
entrez
100507027
canonical
uniprot
P0DMT0
canonical
ensembl
ENSG00000227877
resolver
ensp
ENSP00000488299
resolver
ensp
ENSP00000488429
resolver
ensp
ENSP00000488584
resolver
ensp
ENSP00000488748
resolver
enst
ENST00000414264
resolver
enst
ENST00000430431
resolver
enst
ENST00000594536
resolver
enst
ENST00000628562
resolver
genesymbol
MRLN
resolver
genesymbol_syn
MLN
resolver
hgnc
HGNC:48649
resolver
uniprot_entry
MLN_HUMAN
resolver
amino_acid_sequence
MTGKNWILISTTTPKSLEDEIVGRLLKILFVIFVDLISIIYVVITS
uniprot
proteins
function
FUNCTION: Inhibits the activity of ATP2A1/SERCA1 ATPase in sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+), thereby acting as a key regulator of skeletal muscle activity. Its high expression in adult skeletal muscle, suggests that it constitutes the predominant regulator of ATP2A1/SERCA1 in adult skeletal muscle. Also inhibits the activity of ATP2A2/SERCA2 and ATP2A3/SERCA3. {ECO:0000250|UniProtKB:Q9CV60, ECO:0000269|PubMed:25640239}.
uniprot
proteins
mass_dalton
5194
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
25640239
uniprot
proteins
sequence_length
46
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9CV60}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9CV60}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins