ALDOA
entrez
226
canonical
uniprot
P04075
canonical
ensembl
ENSG00000149925
resolver
ensp
ENSP00000400452
resolver
ensp
ENSP00000455800
resolver
ensp
ENSP00000494188
resolver
ensp
ENSP00000496166
resolver
genesymbol
ALDOA
resolver
genesymbol
HEL-S-87p
resolver
genesymbol_syn
ALDA
resolver
hgnc
HGNC:414
resolver
uniprot
B4DXI7
resolver
uniprot
Q6FH76
resolver
uniprot
Q6FI10
resolver
uniprot
Q96B15
resolver
uniprot
Q9BWD9
resolver
uniprot
Q9UCN2
resolver
uniprot
V9HWN7
resolver
uniprot_entry
ALDOA_HUMAN
resolver
uniprot_entry
V9HWN7_HUMAN
resolver
uniprot_sec
B4DXI7
resolver
uniprot_sec
Q6FH76
resolver
uniprot_sec
Q6FI10
resolver
uniprot_sec
Q96B15
resolver
uniprot_sec
Q9BWD9
resolver
uniprot_sec
Q9UCN2
resolver
amino_acid_sequence
MPYQYPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAIMENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHACTQKFSHEEIAMATVTALRRTVPPAVTGITFLSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAAQEEYVKRALANSLACQGKYTPSGQAGAAASESLFVSNHAY
uniprot
proteins
disease_involvement
DISEASE: Glycogen storage disease 12 (GSD12) [MIM:611881]: A metabolic disorder associated with increased hepatic glycogen and hemolytic anemia. It may lead to myopathy with exercise intolerance and rhabdomyolysis. {ECO:0000269|PubMed:14615364, ECO:0000269|PubMed:14766013, ECO:0000269|PubMed:2229018, ECO:0000269|PubMed:2825199, ECO:0000269|PubMed:8598869}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
4.1.2.13
uniprot
proteins
function
FUNCTION: Catalyzes the reversible conversion of beta-D-fructose 1,6-bisphosphate (FBP) into two triose phosphate and plays a key role in glycolysis and gluconeogenesis (PubMed:14766013). In addition, also functions as a scaffolding protein (By similarity). In response to glucose deprivation, FBP dissociates from aldolase and acts as an adapter that promotes AMP-activated protein kinase (AMPK) activity: mechanistically, associates with transient receptor potential channels TrpV (TRPV1-TRPV4), promoting inhibition of the V-ATPase complex on lysosomes and AMPK activation via the AXIN1-STK11/LKB1 axis (By similarity). {ECO:0000250|UniProtKB:P05064, ECO:0000269|PubMed:14766013}.
uniprot
proteins
mass_dalton
39420
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-39 in response to beta-arrestin-1 (ARRB1) signaling, promoting the fructose-bisphosphate aldolase activity, leading to enhanced glycolysis and improved glucose tolerance. {ECO:0000250|UniProtKB:P05064}.
uniprot
proteins
protein_family
Class I fructose-bisphosphate aldolase family
uniprot
proteins
pubmed
10048322
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
1353685
uniprot
proteins
pubmed
14615364
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14766013
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18214967
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
1999195
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
2056525
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21908771
uniprot
proteins
pubmed
2204832
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
2229018
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
22905912
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2335208
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
2825199
uniprot
proteins
pubmed
29192674
uniprot
proteins
pubmed
29775581
uniprot
proteins
pubmed
3030757
uniprot
proteins
pubmed
3355497
uniprot
proteins
pubmed
3391172
uniprot
proteins
pubmed
3441006
uniprot
proteins
pubmed
3674018
uniprot
proteins
pubmed
3840020
uniprot
proteins
pubmed
6696436
uniprot
proteins
pubmed
8598869
uniprot
proteins
sequence_length
364
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, I band {ECO:0000250|UniProtKB:P00883}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250|UniProtKB:P00883}. Note=In skeletal muscle, accumulates around the M line and within the I band, colocalizing with FBP2 on both sides of the Z line in the absence of Ca(2+). {ECO:0000250|UniProtKB:P00883}.
uniprot
proteins