Fbxo40
entrez
207215
canonical
uniprot
P62932
canonical
ensembl
ENSMUSG00000047746
resolver
ensp
ENSMUSP00000075266
resolver
ensp
ENSMUSP00000110454
resolver
ensp
ENSMUSP00000310845
resolver
enst
ENSMUST00000075869
resolver
enst
ENSMUST00000114806
resolver
genesymbol
Fbxo40
resolver
uniprot
Q3KN92
resolver
uniprot_entry
FBX40_MOUSE
resolver
uniprot_entry
Q3KN92_MOUSE
resolver
amino_acid_sequence
MGRARKPPPALHRHCEGCFNRHCHVPVEPSVSCLVISCHLLCGATFHMCKESEHTLLCPLEQVPCLNSEYGCPLSMARHKLAKHLQVCPASVVCCSMEWIRWPNVDSETFLHENIMKETPSEECLDTALALQDQKVLFRSLKMVELFPETRDATEEEPDMNGDTSWEETGGAVGGVDARLAPNSCLPATSRQMMELSQEERDALAKTKEGMDLDKFGKWESMFSKEHAASVLTGSLGKSEDKNGDVAGKEQCSSNVRIGDAEGSAERRGPQESQKSQELPATMEMTGLAPWQDGVLERLKTAVDAKDYNMYLVHNGRMLIHFGQMPACTPKERDFVYGNLEAQEVKTVYTFKIPVSYCGKRARLGDAMLKCRPSEHKAVDTSDLGISVEDLPKSDLIKTTLQCALERELKGHVISESRSIDGLFMDLATQTYNFEPEQFSSETVLADLLGTAQPGGLHVELHSECVTRRHNKSSSAFTFTCNKFFRRDEFPLHFKNVHTDIQSSLDGWFQHRCPLAYLGCTFVQNHFRPPGQKAKVIYSQELKTFAIKPEVAPELSEKWKSDHLSGRDGKSLNSLTSLPLEVLQYIAGFLDSISLSQLSQVSVLMRNICATLLQERGMVLSQWKKKRYSHGGTSWKVHNQIWQFSSLFSKINSWEFNDVTSMSEHLKTCPFNIVERKTDPIRLTSMCQPQEKARESLVSTFRARPRGRHF
uniprot
proteins
function
FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (PubMed:17928169). Acts as a muscle-specific negative regulator of IGF1 signaling. Mechanistically, promotes polyubiquitination of IRS1 following its IGF1R-induced tyrosine phosphorylation, leading to IRS1 proteasomal degradation and attenuation of the IRS1/PI3K/AKT pathway in differentiated skeletal muscle (PubMed:22033112). Also mediates IRS1 degradation downstream of STAT3 activation in the context of inflammatory insulin resistance (PubMed:32101031). {ECO:0000269|PubMed:17928169, ECO:0000269|PubMed:22033112, ECO:0000269|PubMed:32101031}.
uniprot
proteins
mass_dalton
79951
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17928169
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22033112
uniprot
proteins
pubmed
32101031
uniprot
proteins
sequence_length
710
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17928169}.
uniprot
proteins