Eif5
entrez
108348073
canonical
uniprot
Q07205
canonical
ensembl
ENSRNOG00000010218
resolver
ensembl
ENSRNOG00055028084
resolver
ensembl
ENSRNOG00060027016
resolver
ensembl
ENSRNOG00065025212
resolver
ensp
ENSRNOP00000013695
resolver
ensp
ENSRNOP00055039981
resolver
ensp
ENSRNOP00060039008
resolver
ensp
ENSRNOP00065035632
resolver
enst
ENSRNOT00000013695
resolver
enst
ENSRNOT00055048637
resolver
enst
ENSRNOT00060046908
resolver
enst
ENSRNOT00065043439
resolver
genesymbol
Eif5
resolver
uniprot_entry
IF5_RAT
resolver
amino_acid_sequence
MSVNVNRSVSDQFYRYKMPRLIAKVEGKGNGIKTVIVNMVDVAKALNRPPTYPTKYFGCELGAQTQFDVKNDRYIVNGSHEANKLQDMLDGFIKKFVLCPECENPETDLHVNPKKQTIGNSCKACGYRGMLDTHHKLCTFILKNPPENSDIGTGKKEKEKKNRKGKDKENGSVSTSETPPPPPPNEISPPHAVEEEEDDDWGEDTTEEAQRRRMDEISDHAKGLTLSDDLERTVEERVNILFDFVKKKKEEGIIDSSDKDIVAEAERLDVKAMGPLVLTEVLFDEKIREQIKKYRRHFLRFCHNNKKAQRYLLHGLECVVAMHQAQLISKIPHILKEMYDADLLEEEVIISWSEKASKKYVSKELAKEIRVKAEPFIKWLKEAEEESSGGEEEDEDENIEVVYSKTASVPKVETVKSDNKDDDIDIDAI
uniprot
proteins
function
FUNCTION: Component of the 43S pre-initiation complex (43S PIC), which binds to the mRNA cap-proximal region, scans mRNA 5'-untranslated region, and locates the initiation codon. In this complex, acts as a GTPase-activating protein, by promoting GTP hydrolysis by eIF2G (EIF2S3). During scanning, interacts with both EIF1 (via its C-terminal domain (CTD)) and EIF1A (via its NTD). This interaction with EIF1A contributes to the maintenance of EIF1 within the open 43S PIC. When start codon is recognized, EIF5, via its NTD, induces eIF2G (EIF2S3) to hydrolyze the GTP. Start codon recognition also induces a conformational change of the PIC to a closed state. This change increases the affinity of EIF5-CTD for EIF2-beta (EIF2S2), which allows the release, by an indirect mechanism, of EIF1 from the PIC. Finally, EIF5 stabilizes the PIC in its closed conformation. {ECO:0000250|UniProtKB:P55010}.
uniprot
proteins
mass_dalton
48954
uniprot
proteins
protein_family
EIF-2-beta/eIF-5 family
uniprot
proteins
pubmed
11861906
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8464924
uniprot
proteins
sequence_length
429
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
uniprot
proteins