Acrbp
entrez
54137
canonical
uniprot
Q3V140
canonical
ensembl
ENSMUSG00000072770
resolver
ensp
ENSMUSP00000085632
resolver
ensp
ENSMUSP00000108033
resolver
genesymbol
Acrbp
resolver
uniprot
Q62253
resolver
uniprot
Q62254
resolver
uniprot
Q8C621
resolver
uniprot
Q91VQ1
resolver
uniprot_entry
ACRBP_MOUSE
resolver
uniprot_sec
Q62253
resolver
uniprot_sec
Q62254
resolver
uniprot_sec
Q8C621
resolver
uniprot_sec
Q91VQ1
resolver
amino_acid_sequence
MMNLAAGFLLMLLEVLLLPGTPLSAEESPASTPGSPLSSTEYERFFALLTPTWKAETTCRLRATHGCRNPTLVQLDQYENHGLVPDGAVCSDLPYASWFESFCQFAQYRCSNHVYYAKRVRCSQPVSILSPNTLKEVESSAEVPPTSMTTPIVSHATATEHQAFQPWPERLNNNVEELLQSSLSLGGKDQQSSRRPGQEQRKQEQIQEHKLEEAQEQEEQEEEEEEEEAKQEEGQGTEAGLESVSRLQSDSEPKFQSQSLSSNPSFFTPRVREVESAPLMMKNIQELIRSAQEMDEMNELYDDSWRSQSTGSLQQLPHMETLMVLCYSIMENTCTMTPTAKAWSYMEEEILGFGDSVCDNLGRRHTAACPLCAFCSLKLEQCHSEASVLRQKCDASHKIPFISPLLSAQSISTGNQARIPDKGRFAGLEMYGGLSSEFWCNRLAMKGCEDDRVSNWLKAEFLSFQEGDFPTKICDTNYIQYPNYCSFKSQQCLLRNQNRKMSRMRCMLNERYNVLSLAKSEEVILRWSQEFSTLAIGQFG
uniprot
proteins
function
FUNCTION: Acrosomal protein that maintains proacrosin (pro-ACR) as an enzymatically inactive zymogen in the acrosome. Involved also in the acrosome formation. {ECO:0000269|PubMed:27303034}.; FUNCTION: [Acrosin-binding protein, mature form]: Maintains pro-ACR as an enzymatically inactive zymogen in the acrosome until acrosomal exocytosis (PubMed:27303034). Partially also contributes to the assembly of acrosomal proteins to form an acrosomal granule (PubMed:27303034). {ECO:0000269|PubMed:27303034}.; FUNCTION: [Isoform 2]: Rodent specific isoform that participates in the formation of the acrosomal granule into the center of the acrosomal vesicle during early spermiogenesis (PubMed:27303034). In the fertilization process promotes ACR release from the acrosome during acrosomal exocytosis (PubMed:27303034). {ECO:0000269|PubMed:27303034}.
uniprot
proteins
mass_dalton
61141
uniprot
proteins
post_translational_modification
PTM: The N-terminus is blocked. {ECO:0000250|UniProtKB:Q29016}.; PTM: Phosphorylated on Tyr residues in capacitated sperm. {ECO:0000250|UniProtKB:Q29016}.; PTM: [Isoform 1]: Synthesized as a 60-kDa precursor in pachytene spermatocytes, postmeiotic spermatocytes and haploid spermatids and is processed into the mature protein in elongating spermatids. {ECO:0000269|PubMed:23426433}.; PTM: [Isoform 2]: Degraded in elongating spermatid. {ECO:0000269|PubMed:23426433}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22357636
uniprot
proteins
pubmed
23426433
uniprot
proteins
pubmed
27303034
uniprot
proteins
sequence_length
540
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:27303034}. Note=Colocalized with pro-ACR in the acrosomal granules of early round spermatids. {ECO:0000269|PubMed:23426433}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:22357636, ECO:0000269|PubMed:23426433, ECO:0000269|PubMed:27303034}. Secreted {ECO:0000250|UniProtKB:Q29016}. Note=Highly enriched in acrosomal granules of round spermatids, and spread over the apical end of the nucleus in elongating spermatids. Colocalized in the acrosome of epididymal sperm with pro-ACR. {ECO:0000269|PubMed:23426433}.
uniprot
proteins