ID3
entrez
3399
canonical
uniprot
Q02535
canonical
ensembl
ENSG00000117318
resolver
ensembl
ENSG00000283060
resolver
ensp
ENSP00000363689
resolver
ensp
ENSP00000489102
resolver
ensp
ENSP00000526256
resolver
ensp
ENSP00000588805
resolver
ensp
ENSP00000588806
resolver
ensp
ENSP00000588807
resolver
ensp
ENSP00000588808
resolver
ensp
ENSP00000626518
resolver
enst
ENST00000374561
resolver
enst
ENST00000634790
resolver
enst
ENST00000856197
resolver
enst
ENST00000918746
resolver
enst
ENST00000918747
resolver
enst
ENST00000918748
resolver
enst
ENST00000918749
resolver
enst
ENST00000956459
resolver
genesymbol
ID3
resolver
genesymbol_syn
1R21
resolver
genesymbol_syn
BHLHB25
resolver
genesymbol_syn
HEIR1
resolver
hgnc
HGNC:5362
resolver
uniprot
A8K1T8
resolver
uniprot
O75641
resolver
uniprot_entry
ID3_HUMAN
resolver
uniprot_sec
A8K1T8
resolver
uniprot_sec
O75641
resolver
amino_acid_sequence
MKALSPVRGCYEAVCCLSERSLAIARGRGKGPAAEEPLSLLDDMNHCYSRLRELVPGVPRGTQLSQVEILQRVIDYILDLQVVLAEPAPGPPDGPHLPIQTAELTPELVISNDKRSFCH
uniprot
proteins
function
FUNCTION: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Involved in myogenesis by inhibiting skeletal muscle and cardiac myocyte differentiation and promoting muscle precursor cells proliferation. Inhibits the binding of E2A-containing protein complexes to muscle creatine kinase E-box enhancer. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:8437843}.
uniprot
proteins
mass_dalton
12999
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1628620
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
20861012
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
7828896
uniprot
proteins
pubmed
8437843
uniprot
proteins
sequence_length
119
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins