Tcf3
entrez
21423
canonical
uniprot
P15806
canonical
ensembl
ENSMUSG00000020167
resolver
ensp
ENSMUSP00000020377
resolver
ensp
ENSMUSP00000020379
resolver
ensp
ENSMUSP00000100977
resolver
ensp
ENSMUSP00000100979
resolver
ensp
ENSMUSP00000100980
resolver
ensp
ENSMUSP00000100981
resolver
ensp
ENSMUSP00000100982
resolver
ensp
ENSMUSP00000100983
resolver
ensp
ENSMUSP00000172368
resolver
ensp
ENSMUSP00000172379
resolver
ensp
ENSMUSP00000172383
resolver
ensp
ENSMUSP00000172390
resolver
ensp
ENSMUSP00000172392
resolver
ensp
ENSMUSP00000172393
resolver
ensp
ENSMUSP00000172409
resolver
ensp
ENSMUSP00000172433
resolver
ensp
ENSMUSP00000172434
resolver
enst
ENSMUST00000020377
resolver
enst
ENSMUST00000020379
resolver
enst
ENSMUST00000105340
resolver
enst
ENSMUST00000105342
resolver
enst
ENSMUST00000105343
resolver
enst
ENSMUST00000105344
resolver
genesymbol
Tcf3
resolver
genesymbol_syn
Alf2
resolver
genesymbol_syn
Me2
resolver
genesymbol_syn
Tcfe2a
resolver
uniprot
A0A0R4J011
resolver
uniprot
A0A0R4J014
resolver
uniprot
E9PVV1
resolver
uniprot
E9PVV2
resolver
uniprot
E9PWE2
resolver
uniprot
E9PWE4
resolver
uniprot
Q3U153
resolver
uniprot
Q8CAH9
resolver
uniprot
Q8VCY4
resolver
uniprot
Q922S2
resolver
uniprot
Q99MB8
resolver
uniprot
Q9CYJ4
resolver
uniprot_entry
A0A0R4J011_MOUSE
resolver
uniprot_entry
A0A0R4J014_MOUSE
resolver
uniprot_entry
E9PVV1_MOUSE
resolver
uniprot_entry
E9PVV2_MOUSE
resolver
uniprot_entry
E9PWE2_MOUSE
resolver
uniprot_entry
E9PWE4_MOUSE
resolver
uniprot_entry
TFE2_MOUSE
resolver
uniprot_sec
Q3U153
resolver
uniprot_sec
Q8CAH9
resolver
uniprot_sec
Q8VCY4
resolver
uniprot_sec
Q922S2
resolver
uniprot_sec
Q99MB8
resolver
uniprot_sec
Q9CYJ4
resolver
amino_acid_sequence
MMNQSQRMAPVGSDKELSDLLDFSMMFPLPVANGKSRPASLGGTQFAGSGLEDRPSSGSWGSSDQNSSSFDPSRTYSEGAHFSDSHSSLPPSTFLGAGLGGKGSERNAYATFGRDTSVGTLSQAGFLPGELSLSSPGPLSPSGIKSSSQYYPSFPSNPRRRAADGGLDTQPKKVRKVPPGLPSSVYPPSSGDSYSRDAAAYPSAKTPSSAYPSPFYVADGSLHPSAELWSTPSQVGFGPMLGDGSSPLPLAPGSSSVGSGTFGGLQQQDRMGYQLHGSEVNGSLPAVSSFSAAPGTYSGTSGHTPPVSGAAAESLLGTRGTTASSSGDALGKALASIYSPDHSSNNFSPSPSTPVGSPQGLPGTSQWPRAGAPSALSPNYDAGLHGLSKMEDRLDEAIHVLRSHAVGTASDLHGLLPGHGALTTSFTGPMSLGGRHAGLVGGSHPEEGLTSGASLLHNHASLPSQPSSLPDLSQRPPDSYSGLGRAGTTAGASEIKREEKEDEEIASVADAEEDKKDLKVPRTRTSPDEDEDDLLPPEQKAEREKERRVANNARERLRVRDINEAFKELGRMCQLHLSSEKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVSGVVGDPQLALSAAHPGLGEAHNPAGHL
uniprot
proteins
function
FUNCTION: Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition (PubMed:15226298, PubMed:18214987). Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation (PubMed:18214987). Together with TCF15, required for the mesenchymal to epithelial transition (PubMed:11309385, PubMed:15226298). Dimers bind DNA on E-box motifs: 5'-CANNTG-3' (PubMed:15226298, PubMed:18214987, PubMed:30426815). Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer (By similarity). Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region (PubMed:2181401). {ECO:0000250|UniProtKB:P15923, ECO:0000269|PubMed:11309385, ECO:0000269|PubMed:15226298, ECO:0000269|PubMed:18214987, ECO:0000269|PubMed:2181401}.; FUNCTION: [Isoform E47]: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity. {ECO:0000250|UniProtKB:P15923}.
uniprot
proteins
mass_dalton
67701
uniprot
proteins
post_translational_modification
PTM: Phosphorylated following NGF stimulation. {ECO:0000250}.; PTM: Undergoes Notch-induced ubiquitination and subsequent proteasomal degradation which is mediated by ASB1 or ASB2, the substrate-recognition components of probable ECS E3 ubiquitin-protein ligase complexes. {ECO:0000250|UniProtKB:P15923}.
uniprot
proteins
pubmed
11309385
uniprot
proteins
pubmed
11318877
uniprot
proteins
pubmed
12196028
uniprot
proteins
pubmed
12200424
uniprot
proteins
pubmed
15226298
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16291758
uniprot
proteins
pubmed
16407974
uniprot
proteins
pubmed
18069799
uniprot
proteins
pubmed
18214987
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2181401
uniprot
proteins
pubmed
23395635
uniprot
proteins
pubmed
23938248
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
30426815
uniprot
proteins
pubmed
7589808
uniprot
proteins
pubmed
7875598
uniprot
proteins
pubmed
8112613
uniprot
proteins
pubmed
9409784
uniprot
proteins
sequence_length
651
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12200424}.
uniprot
proteins