Gch1
entrez
29244
canonical
uniprot
P22288
canonical
ensembl
ENSRNOG00000011039
resolver
ensembl
ENSRNOG00055027391
resolver
ensembl
ENSRNOG00060023866
resolver
ensembl
ENSRNOG00065033111
resolver
ensp
ENSRNOP00000014821
resolver
ensp
ENSRNOP00055038992
resolver
ensp
ENSRNOP00060034254
resolver
ensp
ENSRNOP00065046901
resolver
enst
ENSRNOT00000014821
resolver
enst
ENSRNOT00055047412
resolver
enst
ENSRNOT00060041347
resolver
enst
ENSRNOT00065056961
resolver
genesymbol
Gch1
resolver
genesymbol_syn
Gch
resolver
uniprot_entry
GCH1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: GTP shows a positive allosteric effect, and tetrahydrobiopterin inhibits the enzyme activity. Zinc is required for catalytic activity. Inhibited by Mg(2+). {ECO:0000269|PubMed:2557335}.
uniprot
proteins
amino_acid_sequence
MEKPRGVRCTNGFPERELPRPGASRPAEKSRPPEAKGAQPADAWKAGRPRSEEDNELNLPNLAAAYSSILRSLGEDPQRQGLLKTPWRAATAMQFFTKGYQETISDVLNDAIFDEDHDEMVIVKDIDMFSMCEHHLVPFVGRVHIGYLPNKQVLGLSKLARIVEIYSRRLQVQERLTKQIAVAITEALQPAGVGVVIEATHMCMVMRGVQKMNSKTVTSTMLGVFREDPKTREEFLTLIRS
uniprot
proteins
ec_number
3.5.4.16
uniprot
proteins
function
FUNCTION: May positively regulate nitric oxide synthesis in endothelial cells. May be involved in dopamine synthesis (By similarity). May modify pain sensitivity and persistence. {ECO:0000250|UniProtKB:P30793, ECO:0000269|PubMed:17057711}.
uniprot
proteins
mass_dalton
27057
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. {ECO:0000305|PubMed:2557335}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250|UniProtKB:P30793}.
uniprot
proteins
protein_family
GTP cyclohydrolase I family
uniprot
proteins
pubmed
11818540
uniprot
proteins
pubmed
17057711
uniprot
proteins
pubmed
1985963
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2557335
uniprot
proteins
pubmed
7802677
uniprot
proteins
sequence_length
241
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P30793}. Nucleus {ECO:0000250|UniProtKB:P30793}.
uniprot
proteins