KCNJ3
entrez
3760
canonical
uniprot
P48549
canonical
ensembl
ENSG00000162989
resolver
ensp
ENSP00000295101
resolver
ensp
ENSP00000438410
resolver
genesymbol
KCNJ3
resolver
genesymbol_syn
GIRK1
resolver
hgnc
HGNC:6264
resolver
uniprot
B4DEW7
resolver
uniprot
D2X9V0
resolver
uniprot
D2XBF0
resolver
uniprot
Q8TBI0
resolver
uniprot_entry
D2X9V0_HUMAN
resolver
uniprot_entry
D2XBF0_HUMAN
resolver
uniprot_entry
KCNJ3_HUMAN
resolver
uniprot_sec
B4DEW7
resolver
uniprot_sec
Q8TBI0
resolver
activity_regulation
ACTIVITY REGULATION: Heteromultimer composed of KCNJ3/GIRK1 and KCNJ5/GIRK4 is activated by phosphatidylinositol 4,5 biphosphate (PtdIns(4,5)P2). {ECO:0000250|UniProtKB:P63251}.
uniprot
proteins
amino_acid_sequence
MSALRRKFGDDYQVVTTSSSGSGLQPQGPGQDPQQQLVPKKKRQRFVDKNGRCNVQHGNLGSETSRYLSDLFTTLVDLKWRWNLFIFILTYTVAWLFMASMWWVIAYTRGDLNKAHVGNYTPCVANVYNFPSAFLFFIETEATIGYGYRYITDKCPEGIILFLFQSILGSIVDAFLIGCMFIKMSQPKKRAETLMFSEHAVISMRDGKLTLMFRVGNLRNSHMVSAQIRCKLLKSRQTPEGEFLPLDQLELDVGFSTGADQLFLVSPLTICHVIDAKSPFYDLSQRSMQTEQFEIVVILEGIVETTGMTCQARTSYTEDEVLWGHRFFPVISLEEGFFKVDYSQFHATFEVPTPPYSVKEQEEMLLMSSPLIAPAITNSKERHNSVECLDGLDDITTKLPSKLQKITGREDFPKKLLRMSSTTSEKAYSLGDLPMKLQRISSVPGNSEEKLVSKTTKMLSDPMSQSVADLPPKLQKMAGGAARMEGNLPAKLRKMNSDRFT
uniprot
proteins
function
FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This potassium channel is controlled by G proteins (PubMed:8804710, PubMed:8868049). This receptor plays a crucial role in regulating the heartbeat (By similarity). {ECO:0000250|UniProtKB:P63251, ECO:0000269|PubMed:8804710, ECO:0000269|PubMed:8868049}.
uniprot
proteins
mass_dalton
56603
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ3 subfamily
uniprot
proteins
pubmed
10659995
uniprot
proteins
pubmed
10889209
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
8804710
uniprot
proteins
pubmed
8868049
uniprot
proteins
sequence_length
501
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 81..105; /note="Helical; Name=M1"; /evidence="ECO:0000250"; TRANSMEM 158..179; /note="Helical; Name=M2"; /evidence="ECO:0000250
uniprot
proteins