Fgf2
entrez
54250
canonical
uniprot
P13109
canonical
ensembl
ENSRNOG00000017392
resolver
ensembl
ENSRNOG00055002219
resolver
ensembl
ENSRNOG00060006887
resolver
ensembl
ENSRNOG00065008811
resolver
ensp
ENSRNOP00000023388
resolver
ensp
ENSRNOP00055002630
resolver
ensp
ENSRNOP00060008422
resolver
ensp
ENSRNOP00065010489
resolver
enst
ENSRNOT00000023388
resolver
enst
ENSRNOT00055003524
resolver
enst
ENSRNOT00060011282
resolver
enst
ENSRNOT00065014050
resolver
genesymbol
Fgf2
resolver
genesymbol_syn
Fgf-2
resolver
uniprot_entry
FGF2_RAT
resolver
amino_acid_sequence
MAAGSITSLPALPEDGGGAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHVKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTEECFFFERLESNNYNTYRSRKYSSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS
uniprot
proteins
function
FUNCTION: Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Also acts as an integrin ligand which is required for FGF2 signaling (By similarity). Binds to integrin ITGAV:ITGB3 (By similarity). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (By similarity). Functions as a potent mitogen in vitro (By similarity). Can induce angiogenesis (By similarity). Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation (By similarity). {ECO:0000250|UniProtKB:P09038}.
uniprot
proteins
mass_dalton
17139
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Tyr-81 regulates FGF2 unconventional secretion. {ECO:0000250}.
uniprot
proteins
protein_family
Heparin-binding growth factors family
uniprot
proteins
pubmed
1378302
uniprot
proteins
pubmed
3196337
uniprot
proteins
pubmed
3387229
uniprot
proteins
pubmed
9048734
uniprot
proteins
pubmed
9065409
uniprot
proteins
sequence_length
154
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P09038}. Nucleus {ECO:0000250|UniProtKB:P09038}. Note=Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism (By similarity). Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane (By similarity). Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol (By similarity). Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57 (By similarity). {ECO:0000250|UniProtKB:P09038}.
uniprot
proteins