SLC35F2
entrez
54733
canonical
uniprot
Q8IXU6
canonical
ensembl
ENSG00000110660
resolver
ensp
ENSP00000364834
resolver
ensp
ENSP00000436785
resolver
genesymbol
SLC35F2
resolver
hgnc
HGNC:23615
resolver
uniprot
Q14963
resolver
uniprot
Q5JPA8
resolver
uniprot
Q6ZRQ3
resolver
uniprot
Q9H947
resolver
uniprot_entry
S35F2_HUMAN
resolver
uniprot_sec
Q14963
resolver
uniprot_sec
Q5JPA8
resolver
uniprot_sec
Q6ZRQ3
resolver
uniprot_sec
Q9H947
resolver
amino_acid_sequence
MEADSPAGPGAPEPLAEGAAAEFSSLLRRIKGKLFTWNILKTIALGQMLSLCICGTAITSQYLAERYKVNTPMLQSFINYCLLFLIYTVMLAFRSGSDNLLVILKRKWWKYILLGLADVEANYVIVRAYQYTTLTSVQLLDCFGIPVLMALSWFILHARYRVIHFIAVAVCLLGVGTMVGADILAGREDNSGSDVLIGDILVLLGASLYAISNVCEEYIVKKLSRQEFLGMVGLFGTIISGIQLLIVEYKDIASIHWDWKIALLFVAFALCMFCLYSFMPLVIKVTSATSVNLGILTADLYSLFVGLFLFGYKFSGLYILSFTVIMVGFILYCSTPTRTAEPAESSVPPVTSIGIDNLGLKLEENLQETHSAVL
uniprot
proteins
function
FUNCTION: High affinity plasma membrane importer of the nucleobase queuine (q) and its nucleoside queuosine (Q), two bacterially derived micronutrients acquired from the gut microbiome and diet. Following cellular uptake, queuosine is incorporated at the wobble base (position 34) of tRNAs that decode histidine, tyrosine, aspartate, and asparagine codons, which is important for efficient translation. Also involved in choline transport, although the underlying transport mechanism remains to be elucidated (PubMed:40972734). {ECO:0000269|PubMed:40526720, ECO:0000269|PubMed:40972734}.
uniprot
proteins
mass_dalton
41212
uniprot
proteins
protein_family
SLC35F solute transporter family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
40526720
uniprot
proteins
pubmed
40972734
uniprot
proteins
pubmed
9119394
uniprot
proteins
sequence_length
374
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:40526720}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:40526720}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 39..59; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 73..93; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 108..125; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 136..156; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 165..185; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 195..215; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 227..247; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 263..283; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 291..311; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 314..334; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins