Rnf6
entrez
74132
canonical
uniprot
Q9DBU5
canonical
ensembl
ENSMUSG00000029634
resolver
ensp
ENSMUSP00000067559
resolver
ensp
ENSMUSP00000124293
resolver
ensp
ENSMUSP00000128774
resolver
enst
ENSMUST00000067837
resolver
enst
ENSMUST00000161859
resolver
enst
ENSMUST00000169407
resolver
genesymbol
Rnf6
resolver
uniprot
B2RRR0
resolver
uniprot
Q8K565
resolver
uniprot_entry
RNF6_MOUSE
resolver
uniprot_sec
B2RRR0
resolver
uniprot_sec
Q8K565
resolver
amino_acid_sequence
MDPSRSRSGGSGEESSFQENERRWQQERLHREEAYYQFINELSDEDYRLMRDHNLLGTPGEITSEELQQRLERAKEQLASQPGSDSAASDGDSESLRAHSDEDSLLRWLNTFRRTGNVTRSGQNGNQSWRAVSRTNPNSGEFGFSLEIHINPDNRGSEMHGEDSTDIPLSGVNREHRQQRPSSPVARRTRSQTSMSSSGPRGRRGARRQGSVQGSFATLGRLRNGIGVALGVPRVSAPRTNVINSHTNQSDGSTLRQGGRQRFGAAHIWENGARSNVTVRNTNQRLEPIRLRPAFSSRSRSPIQRQNGTVHHNSQRQGRPVQQTGRNRSVRHRGVTRVFLEQGREHRGTDYTPLSNSRLVSRITVEEGESSRSSAATQRHPAITLDLQVRRIRPGETRDRDSIANRTRSRAGLAESTVESTSGGFHRTISHLERSGVRTYVSTITVPLRRISENDVVEPSSVALRSILRQIMTGFGELSSLMEVEPASENQSNGQRLPEVYLELSNGDAADDSGQHGRASSQASQAQDGAEMLAVREPAPPQARPSGSRSRRQLGRADSVVEAGTLPILRLAHFFLLNEGDDDPIRGLTKEQIDNLSTRSYEQDGVDSELGKVCSVCISDYVAGNKLRQLPCLHEFHIHCIDRWLSENCTCPVCRRPVLEFGATSSG
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation (PubMed:16204183). Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover (PubMed:16204183). Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity (By similarity). May also bind DNA and function as a transcriptional regulator (PubMed:11971979). Mediates polyubiquitination of QKI in macrophages, leading to its degradation (PubMed:36088389). {ECO:0000250|UniProtKB:Q9Y252, ECO:0000269|PubMed:11971979, ECO:0000269|PubMed:16204183, ECO:0000269|PubMed:36088389}.
uniprot
proteins
mass_dalton
74091
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:16204183, ECO:0000269|PubMed:36088389}.
uniprot
proteins
protein_family
RNF12 family
uniprot
proteins
pubmed
11971979
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16204183
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
36088389
uniprot
proteins
sequence_length
667
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11971979}. Cytoplasm {ECO:0000269|PubMed:16204183}. Cell projection, axon {ECO:0000269|PubMed:16204183}. Nucleus, PML body {ECO:0000269|PubMed:11971979}. Note=Localizes to the PML nuclear bodies in Sertoli cells. {ECO:0000269|PubMed:11971979}.
uniprot
proteins