SLC39A5
entrez
283375
canonical
uniprot
Q6ZMH5
canonical
ensembl
ENSG00000139540
resolver
ensp
ENSP00000266980
resolver
ensp
ENSP00000405360
resolver
ensp
ENSP00000552026
resolver
ensp
ENSP00000552027
resolver
ensp
ENSP00000552028
resolver
ensp
ENSP00000552029
resolver
ensp
ENSP00000552030
resolver
ensp
ENSP00000552031
resolver
ensp
ENSP00000552033
resolver
ensp
ENSP00000552036
resolver
ensp
ENSP00000552037
resolver
ensp
ENSP00000552038
resolver
ensp
ENSP00000552039
resolver
ensp
ENSP00000552040
resolver
ensp
ENSP00000552041
resolver
ensp
ENSP00000552051
resolver
ensp
ENSP00000552054
resolver
ensp
ENSP00000625342
resolver
ensp
ENSP00000625343
resolver
ensp
ENSP00000791132
resolver
enst
ENST00000266980
resolver
enst
ENST00000454355
resolver
enst
ENST00000881967
resolver
enst
ENST00000881968
resolver
enst
ENST00000881969
resolver
enst
ENST00000881970
resolver
enst
ENST00000881971
resolver
enst
ENST00000881972
resolver
enst
ENST00000881974
resolver
enst
ENST00000881977
resolver
enst
ENST00000881978
resolver
enst
ENST00000881979
resolver
enst
ENST00000881980
resolver
enst
ENST00000881981
resolver
enst
ENST00000881982
resolver
enst
ENST00000881992
resolver
enst
ENST00000881995
resolver
enst
ENST00000955283
resolver
enst
ENST00000955284
resolver
genesymbol
SLC39A5
resolver
genesymbol_syn
ZIP5
resolver
hgnc
HGNC:20502
resolver
uniprot
B2R808
resolver
uniprot
Q8N6Y3
resolver
uniprot_entry
S39A5_HUMAN
resolver
uniprot_sec
B2R808
resolver
uniprot_sec
Q8N6Y3
resolver
amino_acid_sequence
MMGSPVSHLLAGFCVWVVLGWVGGSVPNLGPAEQEQNHYLAQLFGLYGENGTLTAGGLARLLHSLGLGRVQGLRLGQHGPLTGRAASPAADNSTHRPQNPELSVDVWAGMPLGPSGWGDLEESKAPHLPRGPAPSGLDLLHRLLLLDHSLADHLNEDCLNGSQLLVNFGLSPAAPLTPRQFALLCPALLYQIDSRVCIGAPAPAPPGDLLSALLQSALAVLLLSLPSPLSLLLLRLLGPRLLRPLLGFLGALAVGTLCGDALLHLLPHAQEGRHAGPGGLPEKDLGPGLSVLGGLFLLFVLENMLGLLRHRGLRPRCCRRKRRNLETRNLDPENGSGMALQPLQAAPEPGAQGQREKNSQHPPALAPPGHQGHSHGHQGGTDITWMVLLGDGLHNLTDGLAIGAAFSDGFSSGLSTTLAVFCHELPHELGDFAMLLQSGLSFRRLLLLSLVSGALGLGGAVLGVGLSLGPVPLTPWVFGVTAGVFLYVALVDMLPALLRPPEPLPTPHVLLQGLGLLLGGGLMLAITLLEERLLPVTTEG
uniprot
proteins
disease_involvement
DISEASE: Myopia 24, autosomal dominant (MYP24) [MIM:615946]: A refractive error of the eye, in which parallel rays from a distant object come to focus in front of the retina, vision being better for near objects than for far. {ECO:0000269|PubMed:24891338, ECO:0000269|PubMed:25525168}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Uniporter that transports zinc(2+) into polarized cells of enterocytes, pancreatic acinar and endoderm cells across the basolateral membrane and participates, notably, in zinc excretion from the intestine by the uptake of zinc from the blood into the intestine (By similarity). The transport mechanism is temperature- and concentration-dependent and saturable (By similarity). In addition, is also a high affinity copper transporter in vitro (PubMed:36454509). Also may regulate glucose-stimulated insulin secretion (GSIS) in islets primarily through the zinc-activated SIRT1-PPARGC1A axis (By similarity). Could regulate the BMP/TGF-beta (bone morphogenetic protein/transforming growth factor-beta) signaling pathway and modulates extracellular matrix (ECM) proteins of the sclera (PubMed:24891338). Plays a role in eye development (PubMed:24891338). {ECO:0000250|UniProtKB:Q9D856, ECO:0000269|PubMed:24891338, ECO:0000269|PubMed:36454509}.
uniprot
proteins
mass_dalton
56461
uniprot
proteins
mutagenesis
MUTAGEN 372; /note="G->V: Reduced binding to METTL9."; /evidence="ECO:0000269|PubMed:37015930"; MUTAGEN 373; /note="H->A: Reduced histidine methylation by METTL9."; /evidence="ECO:0000269|PubMed:33563959, ECO:0000269|PubMed:37015930"; MUTAGEN 374; /note="S->R: Reduced binding to METTL9."; /evidence="ECO:0000269|PubMed:37015930"; MUTAGEN 375; /note="H->A: Abolished histidine methylation by METTL9."; /evidence="ECO:0000269|PubMed:33563959, ECO:0000269|PubMed:37015930"; MUTAGEN 377; /note="H->A: Does not affect histidine methylation by METTL9."; /evidence="ECO:0000269|PubMed:33563959
uniprot
proteins
post_translational_modification
PTM: Methylated at His-375 by METTL9. {ECO:0000269|PubMed:33563959, ECO:0000269|PubMed:37015930}.; PTM: N-Glycosylated. {ECO:0000250|UniProtKB:Q9D856}.
uniprot
proteins
protein_family
ZIP transporter (TC 2.A.5) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15322118
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
24891338
uniprot
proteins
pubmed
25525168
uniprot
proteins
pubmed
33563959
uniprot
proteins
pubmed
36454509
uniprot
proteins
pubmed
37015930
uniprot
proteins
sequence_length
540
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000250|UniProtKB:Q9D856}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9D856}. Note=Localized to the basolateral surfaces of enterocytes, pancreatic acinar and endoderm cells. During zinc deficiency diet, the basolateral cell membrane localization is lost in the intestine, the visceral yolk sac and acinar cell. During zinc repletion, is relocalized to the basolateral membrane of enterocytes, visceral endoderm cells and pancreatic acinar cells. Zinc can regulate the turnover of protein at the membrane. During zinc deficiency, is internalized and degraded in enterocytes, acinar cells and endoderm cells. Endocytosed through the endolysosomal degradation pathway RAB5A pathway. {ECO:0000250|UniProtKB:Q9D856}.
uniprot
proteins
transmembrane_region
TRANSMEM 213..233; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 245..265; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 288..308; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 445..465; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 471..491; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 509..529; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins