TRPC4AP
entrez
26133
canonical
uniprot
Q8TEL6
canonical
ensembl
ENSG00000100991
resolver
ensp
ENSP00000252015
resolver
ensp
ENSP00000400614
resolver
ensp
ENSP00000558704
resolver
ensp
ENSP00000641047
resolver
ensp
ENSP00000645239
resolver
ensp
ENSP00000645247
resolver
ensp
ENSP00000687368
resolver
ensp
ENSP00000687374
resolver
ensp
ENSP00000687383
resolver
genesymbol
TRPC4AP
resolver
genesymbol_syn
C20orf188
resolver
genesymbol_syn
TRRP4AP
resolver
hgnc
HGNC:16181
resolver
uniprot
B4DW48
resolver
uniprot
E1P5Q0
resolver
uniprot
E1P5Q1
resolver
uniprot
Q96H82
resolver
uniprot
Q9BVB8
resolver
uniprot
Q9H429
resolver
uniprot
Q9UFS6
resolver
uniprot_entry
B4DW48_HUMAN
resolver
uniprot_entry
TP4AP_HUMAN
resolver
uniprot_sec
E1P5Q0
resolver
uniprot_sec
E1P5Q1
resolver
uniprot_sec
Q96H82
resolver
uniprot_sec
Q9BVB8
resolver
uniprot_sec
Q9H429
resolver
uniprot_sec
Q9UFS6
resolver
amino_acid_sequence
MAAAPVAAGSGAGRGRRSAATVAAWGGWGGRPRPGNILLQLRQGQLTGRGLVRAVQFTETFLTERDKQSKWSGIPQLLLKLHTTSHLHSDFVECQNILKEISPLLSMEAMAFVTEERKLTQETTYPNTYIFDLFGGVDLLVEILMRPTISIRGQKLKISDEMSKDCLSILYNTCVCTEGVTKRLAEKNDFVIFLFTLMTSKKTFLQTATLIEDILGVKKEMIRLDEVPNLSSLVSNFDQQQLANFCRILAVTISEMDTGNDDKHTLLAKNAQQKKSLSLGPSAAEINQAALLSIPGFVERLCKLATRKVSESTGTASFLQELEEWYTWLDNALVLDALMRVANEESEHNQASIVFPPPGASEENGLPHTSARTQLPQSMKIMHEIMYKLEVLYVLCVLLMGRQRNQVHRMIAEFKLIPGLNNLFDKLIWRKHSASALVLHGHNQNCDCSPDITLKIQFLRLLQSFSDHHENKYLLLNNQELNELSAISLKANIPEVEAVLNTDRSLVCDGKRGLLTRLLQVMKKEPAESSFRFWQARAVESFLRGTTSYADQMFLLKRGLLEHILYCIVDSECKSRDVLQSYFDLLGELMKFNVDAFKRFNKYINTDAKFQVFLKQINSSLVDSNMLVRCVTLSLDRFENQVDMKVAEVLSECRLLAYISQVPTQMSFLFRLINIIHVQTLTQENVSCLNTSLVILMLARRKERLPLYLRLLQRMEHSKKYPGFLLNNFHNLLRFWQQHYLHKDKDSTCLENSSCISFSYWKETVSILLNPDRQSPSALVSYIEEPYMDIDRDFTEE
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control (PubMed:20551172, PubMed:29779948). The DCX(TRPC4AP) complex specifically mediates the polyubiquitination and subsequent degradation of MYC as part of the DesCEND (destruction via C-end degrons) pathway (PubMed:20551172, PubMed:29779948). The DesCEND (destruction via C-end degrons) pathway recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed:29779948). The DCX(TRPC4AP) complex specifically recognizes proteins with an arginine at the minus 3 position (R-3 motif) at the C-terminus, such as MYC, leading to their ubiquitination and degradation (PubMed:29779948). Also participates in the activation of NFKB1 in response to ligation of TNFRSF1A, possibly by linking TNFRSF1A to the IKK signalosome (By similarity). Involved in JNK activation via its interaction with TRAF2 (By similarity). Also involved in elevation of endoplasmic reticulum Ca(2+) storage reduction in response to CHRM1 (By similarity). {ECO:0000250|UniProtKB:Q9JLV2, ECO:0000269|PubMed:20551172, ECO:0000269|PubMed:29779948}.
uniprot
proteins
mass_dalton
90852
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:20551172}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by GSK3B; phosphorylation is required for ubiquitination. {ECO:0000269|PubMed:26038816}.; PTM: Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase containing SKP2, leading to its degradation (PubMed:26038816). Phosphorylation by GSK3B is required for ubiquitination (PubMed:26038816). {ECO:0000269|PubMed:26038816}.
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19966799
uniprot
proteins
pubmed
20551172
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
26038816
uniprot
proteins
pubmed
29779948
uniprot
proteins
sequence_length
797
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:26038816}.
uniprot
proteins