Kcnk4
entrez
16528
canonical
uniprot
O88454
canonical
ensembl
ENSMUSG00000024957
resolver
ensp
ENSMUSP00000025908
resolver
ensp
ENSMUSP00000159966
resolver
ensp
ENSMUSP00000159967
resolver
enst
ENSMUST00000249872
resolver
genesymbol
Kcnk4
resolver
genesymbol_syn
Traak
resolver
uniprot
A0AAQ4VMR8
resolver
uniprot
Q0VD85
resolver
uniprot_entry
A0AAQ4VMR8_MOUSE
resolver
uniprot_entry
KCNK4_MOUSE
resolver
uniprot_entry
Q0VD85_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Activated by arachidonic acid and other polyunsaturated fatty acids (PubMed:9628867). Not affected by volatile general anesthetics such as chloroform, diethyl ether, halothane and isoflurane (PubMed:10321245). Activated at intracellular and extracellular basic pHs. {ECO:0000269|PubMed:10321245, ECO:0000269|PubMed:27035963, ECO:0000269|PubMed:9628867}.
uniprot
proteins
amino_acid_sequence
MRSTTLLALLALVLLYLVSGALVFQALEQPHEQQAQKKMDHGRDQFLRDHPCVSQKSLEDFIKLLVEALGGGANPETSWTNSSNHSSAWNLGSAFFFSGTIITTIGYGNIVLHTDAGRLFCIFYALVGIPLFGMLLAGVGDRLGSSLRRGIGHIEAIFLKWHVPPGLVRSLSAVLFLLIGCLLFVLTPTFVFSYMESWSKLEAIYFVIVTLTTVGFGDYVPGDGTGQNSPAYQPLVWFWILFGLAYFASVLTTIGNWLRAVSRRTRAEMGGLTAQAASWTGTVTARVTQRTGPSAPPPEKEQPLLPSSLPAPPAVVEPAGRPGSPAPAEKVETPSPPTASALDYPSENLAFIDESSDTQSERGCALPRAPRGRRRPNPSKKPSRPRGPGRLRDKAVPV
uniprot
proteins
function
FUNCTION: K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent 'leak' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, basic pH, temperature and lipids (PubMed:9628867). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (PubMed:27035963, PubMed:27035965). At trigeminal A-beta afferent nerves, the heterodimer of KCNK2/TREK-1 and KCNK4/TRAAK is mostly coexpressed at nodes of Ranvier where it conducts voltage-independent mechanosensitive and thermosensitive currents, allowing rapid action potential repolarization, high speed and high frequence saltatory conduction on myelinated nerves to ensure prompt sensory responses (PubMed:19279663). Permeable to other monovalent cations such as Rb(+) and Cs(+) (By similarity). {ECO:0000250|UniProtKB:G3V8V5, ECO:0000250|UniProtKB:Q9NYG8, ECO:0000269|PubMed:19279663, ECO:0000269|PubMed:27035963, ECO:0000269|PubMed:27035965, ECO:0000269|PubMed:9628867}.
uniprot
proteins
mass_dalton
43052
uniprot
proteins
mutagenesis
MUTAGEN 106; /note="G->E: Decreased channel conductance. Acts as a dominant negative when it assembles with the wild-type subunit. Inactivates KCNK2, KCNK10, and KCNK4 currents by 49%, 32% and 57% respectively. Has weak inhibitory effect on KCNK13, KCNK1 and KCNK9 currents."; /evidence="ECO:0000269|PubMed:27035965
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q9NYG8}.
uniprot
proteins
protein_family
Two pore domain potassium channel (TC 1.A.1.8) family
uniprot
proteins
pubmed
10321245
uniprot
proteins
pubmed
19279663
uniprot
proteins
pubmed
27035963
uniprot
proteins
pubmed
27035965
uniprot
proteins
pubmed
9628867
uniprot
proteins
sequence_length
398
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27035965, ECO:0000269|PubMed:9628867}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:G3V8V5}. Note=Localizes at the Ranvier nodes of myelinated afferent nerves. {ECO:0000250|UniProtKB:G3V8V5}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical; Name=M1"; /evidence="ECO:0000250|UniProtKB:Q9NYG8"; TRANSMEM 119..151; /note="Helical; Name=M2"; /evidence="ECO:0000250|UniProtKB:Q9NYG8"; TRANSMEM 174..195; /note="Helical; Name=M3"; /evidence="ECO:0000250|UniProtKB:Q9NYG8"; TRANSMEM 235..261; /note="Helical; Name=M4"; /evidence="ECO:0000250|UniProtKB:Q9NYG8
uniprot
proteins