SMPD2
entrez
6610
canonical
uniprot
O60906
canonical
ensembl
ENSG00000135587
resolver
ensp
ENSP00000258052
resolver
enst
ENST00000258052
resolver
genesymbol
SMPD2
resolver
hgnc
HGNC:11121
resolver
uniprot
Q5TED1
resolver
uniprot
Q9BWR3
resolver
uniprot_entry
NSMA_HUMAN
resolver
uniprot_sec
Q5TED1
resolver
uniprot_sec
Q9BWR3
resolver
amino_acid_sequence
MKPNFSLRLRIFNLNCWGIPYLSKHRADRMRRLGDFLNQESFDLALLEEVWSEQDFQYLRQKLSPTYPAAHHFRSGIIGSGLCVFSKHPIQELTQHIYTLNGYPYMIHHGDWFSGKAVGLLVLHLSGMVLNAYVTHLHAEYNRQKDIYLAHRVAQAWELAQFIHHTSKKADVVLLCGDLNMHPEDLGCCLLKEWTGLHDAYLETRDFKGSEEGNTMVPKNCYVSQQELKPFPFGVRIDYVLYKAVSGFYISCKSFETTTGFDPHRGTPLSDHEALMATLFVRHSPPQQNPSSTHGPAERSPLMCVLKEAWTELGLGMAQARWWATFASYVIGLGLLLLALLCVLAAGGGAGEAAILLWTPSVGLVLWAGAFYLFHVQEVNGLYRAQAELQHVLGRAREAQDLGPEPQPALLLGQQEGDRTKEQ
uniprot
proteins
ec_number
3.1.4.12
uniprot
proteins
function
FUNCTION: Catalyzes, at least in vitro, the hydrolysis of sphingomyelin to form ceramide and phosphocholine (PubMed:10608884). Also hydrolyzes 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor) in vivo (PubMed:10608884). Also acts on 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and sphingosylphosphocholine (PubMed:10608884, PubMed:14741383). {ECO:0000269|PubMed:10608884, ECO:0000269|PubMed:14741383}.
uniprot
proteins
mass_dalton
47646
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; sphingolipid metabolism. {ECO:0000269|PubMed:10608884, ECO:0000269|PubMed:14741383}.
uniprot
proteins
protein_family
Neutral sphingomyelinase family
uniprot
proteins
pubmed
10608884
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14741383
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9520418
uniprot
proteins
sequence_length
423
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O70572}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 330..350; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 354..374; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins