Slc22a17
entrez
59049
canonical
uniprot
Q9D9E0
canonical
ensembl
ENSMUSG00000022199
resolver
ensp
ENSMUSP00000049676
resolver
ensp
ENSMUSP00000154165
resolver
ensp
ENSMUSP00000154217
resolver
enst
ENSMUST00000228495
resolver
genesymbol
Slc22a17
resolver
genesymbol_syn
Boct
resolver
uniprot
A0A2I3BQG7
resolver
uniprot
Q9WTM1
resolver
uniprot_entry
A0A2I3BQG7_MOUSE
resolver
uniprot_entry
S22AH_MOUSE
resolver
uniprot_sec
Q9WTM1
resolver
amino_acid_sequence
MPSARFGRRGIVLLTLGLVGPCGVGGAAAGSSTGIMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGHFLFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERNRPHGQMLGEEAQEALQELENTCPLPATSTFSFASLLNYRNIWKNLLILGFTNFIAHAIRHCYQPVGGGGSPSDFYLCSLLASGTAALACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLWDYLNDAAITTFSVLGLFSSQASAILSTLLASEVIPTTVRGRGLGLIMALGALGGLSCPAQRLHMGHGAFLQHVVLAACALLCILSIMLLPETKRKLLPEVLRDGELCRRPSLLRQPPPNRCDHVPLLATPNPAL
uniprot
proteins
function
FUNCTION: Cell surface receptor for LCN2 (24p3) that plays a key role in iron homeostasis and transport. Able to bind iron-bound LCN2 (holo-24p3), followed by internalization of holo-24p3 and release of iron, thereby increasing intracellular iron concentration and leading to inhibition of apoptosis. Also binds iron-free LCN2 (apo-24p3), followed by internalization of apo-24p3 and its association with an intracellular siderophore, leading to iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration and resulting in apoptosis. {ECO:0000269|PubMed:16377569}.
uniprot
proteins
mass_dalton
43195
uniprot
proteins
protein_family
Major facilitator (TC 2.A.1) superfamily
uniprot
proteins
protein_family
Organic cation transporter (TC 2.A.1.19) family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16377569
uniprot
proteins
sequence_length
401
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Vacuole membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Upon LCN2-binding, it is internalized. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..30; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 35..55; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 69..89; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 100..120; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 184..203; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 218..238; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 247..267; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 277..297; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 309..329; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 336..356; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins