Plekhg5
entrez
269608
canonical
uniprot
Q66T02
canonical
ensembl
ENSMUSG00000039713
resolver
ensp
ENSMUSP00000101286
resolver
ensp
ENSMUSP00000101287
resolver
ensp
ENSMUSP00000112707
resolver
ensp
ENSMUSP00000158992
resolver
ensp
ENSMUSP00000212424
resolver
ensp
ENSMUSP00000212428
resolver
ensp
ENSMUSP00000212437
resolver
enst
ENSMUST00000105662
resolver
enst
ENSMUST00000118648
resolver
enst
ENSMUST00000239025
resolver
genesymbol
Plekhg5
resolver
genesymbol_syn
Kiaa0720
resolver
genesymbol_syn
Syx
resolver
uniprot
A0A0A0MQC2
resolver
uniprot
A0A5F8MPI8
resolver
uniprot
A2A8B6
resolver
uniprot
A2A8B7
resolver
uniprot
B1AS67
resolver
uniprot
Q66T00
resolver
uniprot
Q6P3B1
resolver
uniprot
Q6ZQ62
resolver
uniprot
Q8R571
resolver
uniprot_entry
A0A0A0MQC2_MOUSE
resolver
uniprot_entry
A0A5F8MPI8_MOUSE
resolver
uniprot_entry
B1AS67_MOUSE
resolver
uniprot_entry
PKHG5_MOUSE
resolver
uniprot_sec
A2A8B6
resolver
uniprot_sec
A2A8B7
resolver
uniprot_sec
Q66T00
resolver
uniprot_sec
Q6P3B1
resolver
uniprot_sec
Q6ZQ62
resolver
uniprot_sec
Q8R571
resolver
amino_acid_sequence
MGTGPGVSGRRAAARPSSELPSPDSQLLWVGGHAHSSDSQVCHHADCQQLHHRGPLNLCETCDSKFHSTLHYDGHVRFDLPPQGSVLARNVSTRSCPPRTSPAADLEEEEEGCTDGKGDRKSAGLKISKKKARRRHTDDPSKECFTLKFDLNVDIETEIVPAMKKKSLGEVLLPVFERKGIALGKVDIYLDQSNTPLSLTFEAYRFGGHYLRVKAKPGDEGKVEQGVKDSKSLSLPALRPSGAGPPVSERVDPQSRRESSLDILAPGRRRKNMSEFLGEAGIPGHEPPAPSSCSLPVGSSGGTSSGINESWKNRAASRFSGFFSSSPSTSAFSREVDKMEQLESKLHAYSLFGLPRMPRRLRFDHDSWEEEEEDDEEDEESSGLRLEDSWRELTDGHEKLTRRQCHQQEAVWELLHTEVSYIRKLRVITNLFLCCLLNLQESGLLCEVEAERLFSNIPEIAKLHRGLWGSVMVPVLEKARRTRALLQPSDFLKGFKMFGSLFKPYIRYCMEEEGCMEYMRGLLRDNDLFRAYVTWAEKHQQCQRLKLSDMLAKPHQRLTKYPLLLKSVLRKTDDPRTKEAIVTMISSVERFIHHVNTCMRQRQERQRLAGVVSRIDAYEVVEGSNDEVDKLLKEFLHLDLTAPMPGTSPEETRQLLLEGSLRMKEGKDSKMDVYCFLFTDLLLVTKAVKKAERTKVIRPPLLVDKIVCRELRDPGSFLLIYLNEFHSAVGAYTFQASSQALCRSWVDTIYNAQNQLQQLRAQLSAQEHPGSQHLQSLEEEEDEQEEEGEESGTSAASSPTILRKSSNSLDSEHCTSDGSTETLAMVVVEPGATLSSPEFEGGPVSSQSDESSLSNTASSVTPTSELLPLGPVDGRSCSMDSAYGTLSPTSLQDFVAPHPVVEPAPVPQTPSPQPSPRLRRRTPVQLLPRPPRLLKSKSEASLLQLLSGTPAARGVPPAPSRSLSELCLISVAPGVRTQRPLQEGGPGWNGPGMCDPCHGPQLSESENRPSHMTGGPADSARRRCREMPSGTMSRVQSEPPSGVSAQHRKLTLAQLYRIRTTLLLNSTLTASEV
uniprot
proteins
function
FUNCTION: Functions as a guanine exchange factor (GEF) for RAB26 and thus regulates autophagy of synaptic vesicles in axon terminal of motoneurons (PubMed:29084947). Involved in the control of neuronal cell differentiation. Plays a role in angiogenesis through regulation of endothelial cells chemotaxis (PubMed:21543326). Also affects the migration, adhesion, and matrix/bone degradation in macrophages and osteoclasts (By similarity). {ECO:0000250|UniProtKB:O94827, ECO:0000269|PubMed:21543326, ECO:0000269|PubMed:29084947}.
uniprot
proteins
mass_dalton
118924
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16467373
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21543326
uniprot
proteins
pubmed
23777631
uniprot
proteins
pubmed
29084947
uniprot
proteins
sequence_length
1073
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16467373}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16467373}. Cell membrane {ECO:0000269|PubMed:16467373}. Cell junction {ECO:0000269|PubMed:21543326}. Cell projection, lamellipodium {ECO:0000269|PubMed:21543326}. Note=Predominantly cytoplasmic, however when endothelial cells are stimulated with lysophosphatidic acid, PLEKHG5 is found in perinuclear regions and at the cell membrane (PubMed:16467373). Localizes at cell-cell junctions in quiescent endothelial cells, and relocalizes to cytoplasmic vesicle and the leading edge of lamellipodia in migrating endothelial cells (PubMed:21543326). {ECO:0000269|PubMed:16467373, ECO:0000269|PubMed:21543326}.
uniprot
proteins