SLC27A1
entrez
376497
canonical
uniprot
Q6PCB7
canonical
ensembl
ENSG00000130304
resolver
ensp
ENSP00000252595
resolver
ensp
ENSP00000535705
resolver
ensp
ENSP00000535706
resolver
ensp
ENSP00000535708
resolver
ensp
ENSP00000535711
resolver
ensp
ENSP00000640301
resolver
ensp
ENSP00000680910
resolver
genesymbol
SLC27A1
resolver
genesymbol_syn
ACSVL5
resolver
genesymbol_syn
FATP1
resolver
hgnc
HGNC:10995
resolver
uniprot
A6NIH2
resolver
uniprot
B7Z662
resolver
uniprot_entry
S27A1_HUMAN
resolver
uniprot_sec
A6NIH2
resolver
uniprot_sec
B7Z662
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by Triacsin C. {ECO:0000250|UniProtKB:Q60714}.
uniprot
proteins
amino_acid_sequence
MRAPGAGAASVVSLALLWLLGLPWTWSAAAALGVYVGSGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRHQRAGHTIPRIFQAVVQRQPERLALVDAGTGECWTFAQLDAYSNAVANLFRQLGFAPGDVVAIFLEGRPEFVGLWLGLAKAGMEAALLNVNLRREPLAFCLGTSGAKALIFGGEMVAAVAEVSGHLGKSLIKFCSGDLGPEGILPDTHLLDPLLKEASTAPLAQIPSKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRMAAFGHHAYRMQAADVLYDCLPLYHSAGNIIGVGQCLIYGLTVVLRKKFSASRFWDDCIKYNCTVVQYIGEICRYLLKQPVREAERRHRVRLAVGNGLRPAIWEEFTERFGVRQIGEFYGATECNCSIANMDGKVGSCGFNSRILPHVYPIRLVKVNEDTMELLRDAQGLCIPCQAGEPGLLVGQINQQDPLRRFDGYVSESATSKKIAHSVFSKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEGVLSRLLGQTDVAVYGVAVPGVEGKAGMAAVADPHSLLDPNAIYQELQKVLAPYARPIFLRLLPQVDTTGTFKIQKTRLQREGFDPRQTSDRLFFLDLKQGHYLPLNEAVYTRICSGAFAL
uniprot
proteins
ec_number
6.2.1.-
uniprot
proteins
ec_number
6.2.1.15
uniprot
proteins
ec_number
6.2.1.3
uniprot
proteins
function
FUNCTION: Mediates the import of long-chain fatty acids (LCFA) into the cell by facilitating their transport at the plasma membrane (PubMed:12556534, PubMed:20530735, PubMed:21395585, PubMed:28178239). Also functions as an acyl-CoA ligase catalyzing the ATP-dependent formation of fatty acyl-CoA using LCFA and very-long-chain fatty acids (VLCFA) as substrates, which prevents fatty acid efflux from cells and might drive more fatty acid uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane-associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LCFA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism (By similarity). Probably involved in fatty acid transport across the blood barrier (PubMed:21395585). {ECO:0000250|UniProtKB:Q60714, ECO:0000269|PubMed:12556534, ECO:0000269|PubMed:20530735, ECO:0000269|PubMed:21395585, ECO:0000269|PubMed:28178239}.
uniprot
proteins
mass_dalton
71108
uniprot
proteins
protein_family
ATP-dependent AMP-binding enzyme family
uniprot
proteins
pubmed
10873384
uniprot
proteins
pubmed
12556534
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20530735
uniprot
proteins
pubmed
21395585
uniprot
proteins
pubmed
28178239
uniprot
proteins
pubmed
30970241
uniprot
proteins
sequence_length
646
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q60714}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q60714}. Endomembrane system {ECO:0000250|UniProtKB:Q60714}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q60714}. Cytoplasm {ECO:0000250|UniProtKB:Q60714}. Note=Plasma membrane and intracellular membranes, at least in adipocytes. In adipocytes, but not myocytes, insulin via the mTORC1 signaling pathway induces a rapid translocation of SLC27A1 from intracellular compartments to the plasma membrane, paralleled by increased LCFA uptake. Insulin-dependent translocation from the cytoplasm to the cell membrane is regulated by EPRS1. Predominantly cytoplasmic in myocytes. {ECO:0000250|UniProtKB:Q60714}.
uniprot
proteins
transmembrane_region
TRANSMEM 14..34; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins