TIPARP
entrez
25976
canonical
uniprot
Q7Z3E1
canonical
ensembl
ENSG00000163659
resolver
ensp
ENSP00000295924
resolver
ensp
ENSP00000418757
resolver
ensp
ENSP00000420612
resolver
ensp
ENSP00000438345
resolver
enst
ENST00000295924
resolver
enst
ENST00000461166
resolver
enst
ENST00000486483
resolver
enst
ENST00000542783
resolver
genesymbol
TIPARP
resolver
genesymbol_syn
PARP7
resolver
hgnc
HGNC:23696
resolver
uniprot
D3DNK6
resolver
uniprot
Q05BQ2
resolver
uniprot
Q68CY9
resolver
uniprot
Q86VP4
resolver
uniprot
Q9Y4P7
resolver
uniprot_entry
PARPT_HUMAN
resolver
uniprot_entry
Q05BQ2_HUMAN
resolver
uniprot_sec
D3DNK6
resolver
uniprot_sec
Q68CY9
resolver
uniprot_sec
Q86VP4
resolver
uniprot_sec
Q9Y4P7
resolver
activity_regulation
ACTIVITY REGULATION: ADP-ribosyltransferase activity is inhibited by PJ34; inhibition is however not specific to TIPARP and other PARP-domain containing proteins are also inhibited by PJ34 (PubMed:30373764). Partially inhibited by KU0058948 (PubMed:30373764). {ECO:0000269|PubMed:30373764}.
uniprot
proteins
amino_acid_sequence
MEMETTEPEPDCVVQPPSPPDDFSCQMRLSEKITPLKTCFKKKDQKRLGTGTLRSLRPILNTLLESGSLDGVFRSRNQSTDENSLHEPMMKKAMEINSSCPPAENNMSVLIPDRTNVGDQIPEAHPSTEAPERVVPIQDHSFPSETLSGTVADSTPAHFQTDLLHPVSSDVPTSPDCLDKVIDYVPGIFQENSFTIQYILDTSDKLSTELFQDKSEEASLDLVFELVNQLQYHTHQENGIEICMDFLQGTCIYGRDCLKHHTVLPYHWQIKRTTTQKWQSVFNDSQEHLERFYCNPENDRMRMKYGGQEFWADLNAMNVYETTEFDQLRRLSTPPSSNVNSIYHTVWKFFCRDHFGWREYPESVIRLIEEANSRGLKEVRFMMWNNHYILHNSFFRREIKRRPLFRSCFILLPYLQTLGGVPTQAPPPLEATSSSQIICPDGVTSANFYPETWVYMHPSQDFIQVPVSAEDKSYRIIYNLFHKTVPEFKYRILQILRVQNQFLWEKYKRKKEYMNRKMFGRDRIINERHLFHGTSQDVVDGICKHNFDPRVCGKHATMFGQGSYFAKKASYSHNFSKKSSKGVHFMFLAKVLTGRYTMGSHGMRRPPPVNPGSVTSDLYDSCVDNFFEPQIFVIFNDDQSYPYFVIQYEEVSNTVSI
uniprot
proteins
ec_number
2.4.2.-
uniprot
proteins
function
FUNCTION: ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins (PubMed:23275542, PubMed:25043379, PubMed:30373764). Acts as a negative regulator of AHR by mediating mono-ADP-ribosylation of AHR, leading to inhibit transcription activator activity of AHR (PubMed:23275542, PubMed:30373764). {ECO:0000269|PubMed:23275542, ECO:0000269|PubMed:25043379, ECO:0000269|PubMed:30373764}.
uniprot
proteins
mass_dalton
76227
uniprot
proteins
mutagenesis
MUTAGEN 39; /note="C->A: Slight reduction of auto-mono-ADP-ribosylation."; /evidence="ECO:0000269|PubMed:23275542, ECO:0000269|PubMed:30373764"; MUTAGEN 41; /note="K->A: Partial relocalization to the cytoplasm."; /evidence="ECO:0000269|PubMed:30373764"; MUTAGEN 243; /note="C->A: Relocalization to the cytosol."; /evidence="ECO:0000269|PubMed:23275542, ECO:0000269|PubMed:30373764"; MUTAGEN 532; /note="H->A: Abolishes ADP-ribosyltransferase activity."; /evidence="ECO:0000269|PubMed:23275542, ECO:0000269|PubMed:30373764"; MUTAGEN 564; /note="Y->A: Abolishes ADP-ribosyltransferase activity."; /evidence="ECO:0000269|PubMed:23275542"; MUTAGEN 631; /note="I->A: Does not affect ADP-ribosyltransferase activity."; /evidence="ECO:0000269|PubMed:23275542
uniprot
proteins
post_translational_modification
PTM: Auto-mono-ADP-ribosylated. {ECO:0000269|PubMed:30373764}.
uniprot
proteins
protein_family
ARTD/PARP family
uniprot
proteins
pubmed
12851707
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
20106667
uniprot
proteins
pubmed
23275542
uniprot
proteins
pubmed
25043379
uniprot
proteins
pubmed
30373764
uniprot
proteins
sequence_length
657
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23275542, ECO:0000269|PubMed:30373764}.
uniprot
proteins