Otop2
entrez
237987
canonical
uniprot
Q80SX5
canonical
ensembl
ENSMUSG00000050201
resolver
ensp
ENSMUSP00000062109
resolver
ensp
ENSMUSP00000102154
resolver
ensp
ENSMUSP00000284893
resolver
ensp
ENSMUSP00000284894
resolver
enst
ENSMUST00000055490
resolver
enst
ENSMUST00000106544
resolver
genesymbol
Otop2
resolver
uniprot
Q8CE77
resolver
uniprot_entry
OTOP2_MOUSE
resolver
uniprot_sec
Q8CE77
resolver
activity_regulation
ACTIVITY REGULATION: Active at neutral and alkaline extracellular pH, acid extracellular pH appears to inhibit the channel (PubMed:35920807). Insensitive to activation by Zn(2+) (PubMed:37053086). {ECO:0000269|PubMed:35920807, ECO:0000269|PubMed:37053086}.
uniprot
proteins
amino_acid_sequence
MSEELVPHPNESLPGPRASPREVWKKGGRLLSVLLAVNVLLLACTLISGGAFNKVAVYDTDVFALLTTMMLLAALWIVFYLLRTARCPDAVPYRDAHAGPIWLRGGLVLFGICTLVMDVFKTGYYSSFFECQSAIKILHPIIQAVFVIVQTYFLWISAKDCIHTHLDLTRCGLMFTLATNLAIWMAAVVDESVHQAHSYSGSHGNTSHTRLNPDSKRAGGAAEEDPCLCSTAICQIFQQGYFYLYPFNIEYSLFASTMLYVMWKNVGRLLASTHGHGHTPSRVSLFRETFFAGPVLGLLLFVVGLAVFILYEVQVSGERGHTRQALVIYYSFNIVCLGLMTLVSLSGSVIYRFDRRAMDHHKNPTRTLDVALLMGAALGQYAISYYSIVAVVVGSPRDLQGALNLSHALLMIAQHTFQNVFIIESLHRGPPGAEPREMPPKEPCQGITFANLDAIRTLPSCPPTPRLVIPNLESPQEAVAIISAPRCHWRRRCLKDISLFLLLCNVILWIMPAFGARPHFSNTVEVDFYGYSLWAAIVNICLPFGIFYRMHAVSSLLEVYVLS
uniprot
proteins
function
FUNCTION: Proton-selective ion channel open at neutral pH (PubMed:29371428, PubMed:35920807, PubMed:37053086). Active at neutral and alkaline extracellular pH, likely participates in some alkali-related physiological activities (PubMed:35920807, PubMed:37053086). {ECO:0000269|PubMed:29371428, ECO:0000269|PubMed:35920807, ECO:0000269|PubMed:37053086}.
uniprot
proteins
mass_dalton
62582
uniprot
proteins
protein_family
Otopetrin family
uniprot
proteins
pubmed
12651873
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
29371428
uniprot
proteins
pubmed
35920807
uniprot
proteins
pubmed
37053086
uniprot
proteins
sequence_length
563
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q80VM9}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 30..50; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 62..82; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 100..120; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 137..157; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 173..193; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 242..262; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 290..310; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 325..345; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 373..393; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 403..423; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 496..516; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 528..548; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins