Otud5
entrez
363452
canonical
uniprot
Q2YDU3
canonical
ensembl
ENSRNOG00000008764
resolver
ensp
ENSRNOP00000006233
resolver
ensp
ENSRNOP00000090218
resolver
enst
ENSRNOT00000006233
resolver
enst
ENSRNOT00000112857
resolver
genesymbol
Otud5
resolver
uniprot
A0A0H2UHD0
resolver
uniprot
A0A8I6AAB2
resolver
uniprot_entry
A0A0H2UHD0_RAT
resolver
uniprot_entry
A0A8I6AAB2_RAT
resolver
uniprot_entry
OTUD5_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by N-ethyl-maleimide (NEM). {ECO:0000250|UniProtKB:Q96G74}.
uniprot
proteins
amino_acid_sequence
MTILPKKKPPPPDADPANEPPPPGPLPPAPRRGGGVGVGGGGTGVGGGERDRDSGVVGARPRASPPPQGPLPGPPGALHRWALAVPPGAVAGPRPQQASPPPCGGPGGPGGGPGDALGATTAGVGAAGVVVGVGGPVGVGGCCSGPGHSKRRRQAPGVGAVGGASPEREEVGAGYNSEDEYEAAAARIEAMDPATVEQQEHWFEKALRDKKGFIIKQMKEDGACLFRAVADQVYGDQDMHEVVRKHCMDYLMKNADYFSNYVTEDFTTYINRKRKNNCHGNHIEMQAMAEMYNRPVEVYQYSTEPINTFHGIHQNEDEPIRVSYHRNIHYNSVVNPNKATIGVGLGLPSFKPGFAEQSLMKNAIKTSEESWIEQQMLEDKKRATDWEATNEAIEEQVARESYLQWLRDQEKQARQVRGPSQPRKASATCSSATAAASSGLEEWTSRSPRQRSSASSPEHPELHAELGIKPPSPGTVLALAKPPSPCAPGTSSQFSAGADRATSPLVSLYPALECRALIQQMSPSAFGLNDWDDDEILASVLAVSQQEYLDSMKKNKVHRDPPPDKS
uniprot
proteins
ec_number
3.4.19.12
uniprot
proteins
function
FUNCTION: Deubiquitinating enzyme that functions as a negative regulator of the innate immune system. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro). Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1. Acts as a positive regulator of mTORC1 and mTORC2 signaling following phosphorylation by MTOR: acts by mediating deubiquitination of BTRC, leading to its stability. {ECO:0000250|UniProtKB:Q96G74}.
uniprot
proteins
mass_dalton
60288
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-177 is required for deubiquitinating activity. Phosphorylation at Ser-323, Ser-332 and Ser-503 by MTOR promotes its activity. {ECO:0000250|UniProtKB:Q96G74}.
uniprot
proteins
protein_family
Peptidase C85 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
566
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96G74}.
uniprot
proteins