Aph1c
entrez
68318
canonical
uniprot
Q9DCZ9
canonical
ensembl
ENSMUSG00000053040
resolver
ensp
ENSMUSP00000056476
resolver
ensp
ENSMUSP00000130359
resolver
enst
ENSMUST00000057261
resolver
enst
ENSMUST00000169282
resolver
genesymbol
Aph1c
resolver
genesymbol_syn
APH-1b
resolver
uniprot
F8WJ76
resolver
uniprot
Q3U2R3
resolver
uniprot
Q4R1J7
resolver
uniprot_entry
APH1C_MOUSE
resolver
uniprot_entry
F8WJ76_MOUSE
resolver
uniprot_entry
Q4R1J7_MOUSE
resolver
uniprot_sec
Q3U2R3
resolver
amino_acid_sequence
MTLPVFFGCAFIAFGPAFALYLFTIATDPLRVIFLIAGAFFWLVSLLLSSMFWFLVRVITNNRDESVQNYLLIFGALLSVCIQELFRLAYYKLLKKASEGLKSINPEEDIAPSMRLLAYVSGLGFGIMSGVFSFVNTLSNSLGPGTVGIHGDSPQFFLNSAFMTLVVIMLHVFWGVVFFDGCEKNKWYTLLTVLLTHLVVSTQTFLSPYYEVNLVTAYIIMVLMGIWAFYVAGGSCRSLKFCLLCQDKDFLLYNQRSR
uniprot
proteins
function
FUNCTION: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). {ECO:0000250}.
uniprot
proteins
mass_dalton
29045
uniprot
proteins
protein_family
APH-1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
258
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..25; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 32..52; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 71..91; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 116..136; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 161..181; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 187..207; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 214..234; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins