PTGDR
entrez
5729
canonical
uniprot
Q13258
canonical
ensembl
ENSG00000168229
resolver
ensp
ENSP00000303424
resolver
ensp
ENSP00000452408
resolver
genesymbol
PTGDR
resolver
hgnc
HGNC:9591
resolver
uniprot
G3V5L3
resolver
uniprot
Q13250
resolver
uniprot
Q13251
resolver
uniprot
Q1ZZ52
resolver
uniprot_entry
PD2R_HUMAN
resolver
uniprot_sec
G3V5L3
resolver
uniprot_sec
Q13250
resolver
uniprot_sec
Q13251
resolver
uniprot_sec
Q1ZZ52
resolver
amino_acid_sequence
MKSPFYRCQNTTSVEKGNSAVMGGVLFSTGLLGNLLALGLLARSGLGWCSRRPLRPLPSVFYMLVCGLTVTDLLGKCLLSPVVLAAYAQNRSLRVLAPALDNSLCQAFAFFMSFFGLSSTLQLLAMALECWLSLGHPFFYRRHITLRLGALVAPVVSAFSLAFCALPFMGFGKFVQYCPGTWCFIQMVHEEGSLSVLGYSVLYSSLMALLVLATVLCNLGAMRNLYAMHRRLQRHPRSCTRDCAEPRADGREASPQPLEELDHLLLLALMTVLFTMCSLPVIYRAYYGAFKDVKEKNRTSEEAEDLRALRFLSVISIVDPWIFIIFRSPVFRIFFHKIFIRPLRYRSRCSNSTNMESSL
uniprot
proteins
disease_involvement
DISEASE: Asthma-related traits 1 (ASRT1) [MIM:607277]: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. {ECO:0000269|PubMed:15496624}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Receptor for prostaglandin D2 (PGD2). The activity of this receptor is mainly mediated by G(s) proteins that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. A mobilization of calcium is also observed, but without formation of inositol 1,4,5-trisphosphate (By similarity). Involved in PLA2G3-dependent maturation of mast cells. PLA2G3 is secreted by immature mast cells and acts on nearby fibroblasts upstream to PTDGS to synthesize PGD2, which in turn promotes mast cell maturation and degranulation via PTGDR (By similarity). {ECO:0000250|UniProtKB:P70263, ECO:0000250|UniProtKB:Q9R261}.
uniprot
proteins
mass_dalton
40271
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11082108
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15496624
uniprot
proteins
pubmed
6302737
uniprot
proteins
pubmed
7642548
uniprot
proteins
sequence_length
359
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 60..80; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 108..128; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 151..171; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 196..216; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 263..283; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 311..331; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins