Selenoi
entrez
28042
canonical
uniprot
Q80TA1
canonical
ensembl
ENSMUSG00000075703
resolver
ensp
ENSMUSP00000118368
resolver
genesymbol
Selenoi
resolver
genesymbol_syn
D5Wsu178e
resolver
genesymbol_syn
Ept1
resolver
genesymbol_syn
Kiaa1724
resolver
uniprot
Q3KQQ5
resolver
uniprot
Q8BG08
resolver
uniprot_entry
EPT1_MOUSE
resolver
uniprot_sec
Q3KQQ5
resolver
uniprot_sec
Q8BG08
resolver
amino_acid_sequence
MAGYEYVSPEQLSGFDKYKYSALDTNPLSLYIMHPFWNTIVKVFPTWLAPNLITFSGFMLLVFNFLLLTYFDPDFYASAPGHKHVPDWVWIVVGILNFAAYTLDGVDGKQARRTNSSTPLGELFDHGLDSWSCVYFVVTVYSIFGRGPTGVSVFVLYLLLWVVLFSFILSHWEKYNTGVLFLPWGYDISQVTISFVYIVTAVVGVEAWYEPFLFNFLYRDLFTAMIIGCALCVTLPMSLLNFFRSYKSNTLKHKSVYEAMVPFFSPCLLFTLCTVWILWSPSDILEIHPRIFYFMVGTAFANITCQLIVCQMSSTRCPTLNWLLLPLLLVVAAVIVGAATSRLESALLYTLTAAFTLAHIHYGVQVVKQLSRHFQIYPFSLRKPNSDULGMEEQNIGL
uniprot
proteins
ec_number
2.7.8.1
uniprot
proteins
function
FUNCTION: Ethanolaminephosphotransferase that catalyzes the transfer of phosphoethanolamine (PE) from CDP-ethanolamine to lipid acceptors, the final step in the synthesis of PE via the 'Kennedy' pathway (By similarity). PE is the second most abundant phospholipid of membranes in mammals and is involved in various membrane-related cellular processes (By similarity). The enzyme is critical for the synthesis of several PE species and also catalyzes the synthesis of plasmanyl-PE, a lipid required for proper myelination and neurodevelopment, from 1-alkyl-2-acylglycerol (PubMed:38582453). {ECO:0000250|UniProtKB:Q9C0D9, ECO:0000269|PubMed:38582453}.
uniprot
proteins
mass_dalton
45346
uniprot
proteins
pathway_participation
PATHWAY: Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 3/3. {ECO:0000250|UniProtKB:Q9C0D9}.
uniprot
proteins
protein_family
CDP-alcohol phosphatidyltransferase class-I family
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
32502470
uniprot
proteins
pubmed
38582453
uniprot
proteins
sequence_length
398
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9C0D9}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9C0D9}.
uniprot
proteins
transmembrane_region
TRANSMEM 47..69; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 84..103; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 123..145; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 150..172; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 179..201; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 221..243; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 256..278; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 291..310; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 319..341; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 345..367; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins