Rab28
entrez
100972
canonical
uniprot
Q99KL7
canonical
ensembl
ENSMUSG00000029128
resolver
ensp
ENSMUSP00000031011
resolver
ensp
ENSMUSP00000144440
resolver
ensp
ENSMUSP00000144541
resolver
ensp
ENSMUSP00000274423
resolver
enst
ENSMUST00000031011
resolver
enst
ENSMUST00000201422
resolver
enst
ENSMUST00000202913
resolver
genesymbol
Rab28
resolver
uniprot
A0A0J9YV15
resolver
uniprot
A0A0J9YV85
resolver
uniprot
Q3TTF7
resolver
uniprot
Q3TWY9
resolver
uniprot
Q9CZQ8
resolver
uniprot_entry
A0A0J9YV15_MOUSE
resolver
uniprot_entry
A0A0J9YV85_MOUSE
resolver
uniprot_entry
Q3TTF7_MOUSE
resolver
uniprot_entry
Q3TWY9_MOUSE
resolver
uniprot_entry
Q9CZQ8_MOUSE
resolver
uniprot_entry
RAB28_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000250|UniProtKB:P51157}.
uniprot
proteins
amino_acid_sequence
MSDSEEESQDRQLKIVVLGDGTSGKTSLATCFAQETFGKQYKQTIGLDFFLRRITLPGNLNVTLQVWDIGGQTIGGKMLDKYIYGAQGILLVYDITNYQSFENLEDWYSVVKTVSEESETQPLVALVGNKIDLEHMRTVKADKHLRFCQENGFSSHFVSAKTGDSVFLCFQKVAAEILGIKLNKAEIEQSQRVVKADIVNYNQEPLSRTVNPPRSSMCAVQ
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB28 is required for shedding and phagocytosis of cone cell outer segments (OS) discs in the retina (PubMed:30228185). Also participates in nuclear factor kappa-B p65/RELA nuclear transport in endothelial cells (By similarity). {ECO:0000250|UniProtKB:P51157, ECO:0000250|UniProtKB:P51158, ECO:0000269|PubMed:30228185}.
uniprot
proteins
mass_dalton
24728
uniprot
proteins
post_translational_modification
PTM: Prenylated. {ECO:0000269|PubMed:30228185}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30228185
uniprot
proteins
sequence_length
221
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:P51158}. Cytoplasm {ECO:0000269|PubMed:30228185}. Nucleus {ECO:0000250|UniProtKB:P51158}. Note=Expressed in the basal body and ciliary rootlet of the photoreceptor cells. Localized in the cytoplasm and the nucleus of vascular endothelial cells. {ECO:0000250|UniProtKB:P51158}.
uniprot
proteins