RASEF
entrez
158158
canonical
uniprot
Q8IZ41
canonical
ensembl
ENSG00000165105
resolver
ensp
ENSP00000365630
resolver
ensp
ENSP00000543490
resolver
genesymbol
RASEF
resolver
genesymbol_syn
RAB45
resolver
hgnc
HGNC:26464
resolver
uniprot
A6NC29
resolver
uniprot
Q96N04
resolver
uniprot_entry
RASEF_HUMAN
resolver
uniprot_sec
A6NC29
resolver
uniprot_sec
Q96N04
resolver
amino_acid_sequence
MEADGDGEELARLRSVFAACDANRSGRLEREEFRALCTELRVRPADAEAVFQRLDADRDGAITFQEFARGFLGSLRGGRRRDWGPLDPAPAVSEAGPETHDSEEDEGDEDAAAALATSCGPASPGRAWQDFQARLGDEAKFIPREEQVSTLYQNINLVEPRLIQPYEHVIKNFIREIRLQSTEMENLAIAVKRAQDKAAMQLSELEEEMDQRIQAAEHKTRKDEKRKAEEALSDLRRQYETEVGDLQVTIKKLRKLEEQSKRVSQKEDVAALKKQIYDLSMENQKVKKDLLEAQTNIAFLQSELDALKSDYADQSLNTERDLEIIRAYTEDRNSLERQIEILQTANRKLHDSNDGLRSALENSYSKFNRSLHINNISPGNTISRSSPKFIGHSPQPLGYDRSSRSSYVDEDCDSLALCDPLQRTNCEVDSLPESCFDSGLSTLRDPNEYDSEVEYKHQRGFQRSHGVQESFGGDASDTDVPDIRDEETFGLEDVASVLDWKPQGSVSEGSIVSSSRKPISALSPQTDLVDDNAKSFSSQKAYKIVLAGDAAVGKSSFLMRLCKNEFRENISATLGVDFQMKTLIVDGERTVLQLWDTAGQERFRSIAKSYFRKADGVLLLYDVTCEKSFLNIREWVDMIEDAAHETVPIMLVGNKADIRDTAATEGQKCVPGHFGEKLAMTYGALFCETSAKDGSNIVEAVLHLAREVKKRTDKDDSRSITNLTGTNSKKSPQMKNCCNG
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: [Isoform 1]: Rab GTPase that acts as a dynein adapter protein, thereby activating dynein-mediated transport and dynein-dynactin motility on microtubules (PubMed:30814157). RASEF-mediated dynein motility is Ca(2+)-independent (PubMed:30814157). Also regulates the formation and sorting of zymogen granules and secretion of digestive enzymes by pancreatic acinar cells (By similarity). {ECO:0000250|UniProtKB:Q5RI75, ECO:0000269|PubMed:30814157}.
uniprot
proteins
mass_dalton
82879
uniprot
proteins
mutagenesis
MUTAGEN 555; /note="S->N: Impairs nucleotide binding and perinuclear localization."; /evidence="ECO:0000269|PubMed:17448446"; MUTAGEN 600; /note="Q->L: Favors GTP association."; /evidence="ECO:0000269|PubMed:17448446
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16015647
uniprot
proteins
pubmed
16174859
uniprot
proteins
pubmed
17448446
uniprot
proteins
pubmed
30814157
uniprot
proteins
pubmed
38901651
uniprot
proteins
sequence_length
740
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:17448446}. Cytoplasm {ECO:0000269|PubMed:38901651}. Golgi apparatus {ECO:0000269|PubMed:38901651}. Early endosome {ECO:0000269|PubMed:38901651}. Late endosome {ECO:0000269|PubMed:38901651}. Lysosome {ECO:0000269|PubMed:38901651}. Note=Mostly diffusely distributed in the cytoplasm and partially localized to Golgi and endo-lysosomes in pancreatic cells. {ECO:0000269|PubMed:38901651}.
uniprot
proteins