Gnb5
entrez
14697
canonical
uniprot
P62881
canonical
ensembl
ENSMUSG00000032192
resolver
ensp
ENSMUSP00000149938
resolver
ensp
ENSMUSP00000150492
resolver
genesymbol
Gnb5
resolver
uniprot
O35354
resolver
uniprot
P54314
resolver
uniprot
Q3UG14
resolver
uniprot
Q91WB3
resolver
uniprot_entry
GNB5_MOUSE
resolver
uniprot_entry
Q3UG14_MOUSE
resolver
uniprot_sec
O35354
resolver
uniprot_sec
P54314
resolver
uniprot_sec
Q91WB3
resolver
amino_acid_sequence
MCDQTFLVNVFGSCDKCFKQRALRPVFKKSQQLNYCSTCAEIMATDGLHENETLASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDVNSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVWA
uniprot
proteins
function
FUNCTION: Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, such as RGS7 and RGS9, hence involved in the termination of the signaling initiated by the G protein-coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation (By similarity). Increases RGS7 GTPase-activating protein (GAP) activity, thereby regulating mood and cognition (By similarity). Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors (By similarity). May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate (By similarity). {ECO:0000250|UniProtKB:A1L271, ECO:0000250|UniProtKB:O14775}.
uniprot
proteins
mass_dalton
43565
uniprot
proteins
protein_family
WD repeat G protein beta family
uniprot
proteins
pubmed
12119397
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16908407
uniprot
proteins
pubmed
18204463
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31311860
uniprot
proteins
pubmed
34793198
uniprot
proteins
pubmed
8071339
uniprot
proteins
pubmed
8910430
uniprot
proteins
sequence_length
395
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:8071339, ECO:0000269|PubMed:8910430}.
uniprot
proteins