NKIRAS1
entrez
28512
canonical
uniprot
Q9NYS0
canonical
ensembl
ENSG00000197885
resolver
ensp
ENSP00000373411
resolver
ensp
ENSP00000392307
resolver
ensp
ENSP00000393785
resolver
ensp
ENSP00000394214
resolver
ensp
ENSP00000400385
resolver
ensp
ENSP00000483749
resolver
ensp
ENSP00000526742
resolver
ensp
ENSP00000526743
resolver
ensp
ENSP00000526744
resolver
ensp
ENSP00000526745
resolver
ensp
ENSP00000526746
resolver
ensp
ENSP00000526747
resolver
ensp
ENSP00000526748
resolver
ensp
ENSP00000526749
resolver
ensp
ENSP00000526750
resolver
ensp
ENSP00000526751
resolver
ensp
ENSP00000526752
resolver
ensp
ENSP00000526753
resolver
ensp
ENSP00000583359
resolver
ensp
ENSP00000583360
resolver
ensp
ENSP00000583361
resolver
ensp
ENSP00000583362
resolver
ensp
ENSP00000583363
resolver
ensp
ENSP00000611440
resolver
ensp
ENSP00000611442
resolver
ensp
ENSP00000611444
resolver
ensp
ENSP00000702813
resolver
enst
ENST00000388759
resolver
enst
ENST00000416026
resolver
enst
ENST00000421515
resolver
enst
ENST00000425478
resolver
enst
ENST00000443659
resolver
enst
ENST00000614374
resolver
enst
ENST00000856683
resolver
enst
ENST00000856684
resolver
enst
ENST00000856685
resolver
enst
ENST00000856686
resolver
enst
ENST00000856687
resolver
enst
ENST00000856688
resolver
enst
ENST00000856689
resolver
enst
ENST00000856690
resolver
enst
ENST00000856691
resolver
enst
ENST00000856692
resolver
enst
ENST00000856693
resolver
enst
ENST00000856694
resolver
enst
ENST00000913300
resolver
enst
ENST00000913301
resolver
enst
ENST00000913302
resolver
enst
ENST00000913303
resolver
enst
ENST00000913304
resolver
enst
ENST00000941381
resolver
enst
ENST00000941383
resolver
enst
ENST00000941385
resolver
genesymbol
NKIRAS1
resolver
genesymbol_syn
KBRAS1
resolver
hgnc
HGNC:17899
resolver
uniprot
Q96K18
resolver
uniprot_entry
KBRS1_HUMAN
resolver
uniprot_sec
Q96K18
resolver
amino_acid_sequence
MGKGCKVVVCGLLSVGKTAILEQLLYGNHTIGMEDCETMEDVYMASVETDRGVKEQLHLYDTRGLQEGVELPKHYFSFADGFVLVYSVNNLESFQRVELLKKEIDKFKDKKEVAIVVLGNKIDLSEQRQVDAEVAQQWAKSEKVRLWEVTVTDRKTLIEPFTLLASKLSQPQSKSSFPLPGRKNKGNSNSEN
uniprot
proteins
function
FUNCTION: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB. {ECO:0000269|PubMed:10657303, ECO:0000269|PubMed:12672800, ECO:0000269|PubMed:15024091}.
uniprot
proteins
mass_dalton
21643
uniprot
proteins
mutagenesis
MUTAGEN 38; /note="T->A: Loss of function."; /evidence="ECO:0000269|PubMed:15024091
uniprot
proteins
protein_family
KappaB-Ras subfamily
uniprot
proteins
protein_family
Ras family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10657303
uniprot
proteins
pubmed
12672800
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15024091
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
192
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15024091}.
uniprot
proteins