NTAQ1
entrez
55093
canonical
uniprot
Q96HA8
canonical
ensembl
ENSG00000156795
resolver
ensp
ENSP00000287387
resolver
ensp
ENSP00000428615
resolver
ensp
ENSP00000430427
resolver
enst
ENST00000523356
resolver
genesymbol
NTAQ1
resolver
genesymbol_syn
C8orf32
resolver
genesymbol_syn
WDYHV1
resolver
hgnc
HGNC:25490
resolver
uniprot
B4DE68
resolver
uniprot
E5RHC2
resolver
uniprot
Q9NW95
resolver
uniprot_entry
E5RHC2_HUMAN
resolver
uniprot_entry
NTAQ1_HUMAN
resolver
uniprot_sec
B4DE68
resolver
uniprot_sec
Q9NW95
resolver
amino_acid_sequence
MEGNGPAAVHYQPASPPRDACVYSSCYCEENIWKLCEYIKNHDQYPLEECYAVFISNERKMIPIWKQQARPGDGPVIWDYHVVLLHVSSGGQNFIYDLDTVLPFPCLFDTYVEDAFKSDDDIHPQFRRKFRVIRADSYLKNFASDRSHMKDSSGNWREPPPPYPCIETGDSKMNLNDFISMDPKVGWGAVYTLSEFTHRFGSKNC
uniprot
proteins
ec_number
3.5.1.122
uniprot
proteins
function
FUNCTION: Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N-terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C-terminal glutamine and does not act on non-glutamine residues in any position. Does not deaminate acetylated N-terminal glutamine. With the exception of proline, all tested second-position residues on substrate peptides do not greatly influence the activity. In contrast, a proline at position 2, virtually abolishes deamidation of N-terminal glutamine. {ECO:0000250|UniProtKB:Q80WB5}.
uniprot
proteins
mass_dalton
23680
uniprot
proteins
protein_family
NTAQ1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
25356641
uniprot
proteins
sequence_length
205
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q80WB5}. Nucleus {ECO:0000250|UniProtKB:Q80WB5}.
uniprot
proteins