Chl1
entrez
12661
canonical
uniprot
P70232
canonical
ensembl
ENSMUSG00000030077
resolver
ensp
ENSMUSP00000063933
resolver
ensp
ENSMUSP00000275666
resolver
ensp
ENSMUSP00000275667
resolver
ensp
ENSMUSP00000275668
resolver
ensp
ENSMUSP00000275669
resolver
ensp
ENSMUSP00000275670
resolver
ensp
ENSMUSP00000275677
resolver
ensp
ENSMUSP00000275678
resolver
ensp
ENSMUSP00000275682
resolver
ensp
ENSMUSP00000275684
resolver
ensp
ENSMUSP00000275685
resolver
ensp
ENSMUSP00000275688
resolver
ensp
ENSMUSP00000275689
resolver
ensp
ENSMUSP00000275693
resolver
genesymbol
Chl1
resolver
genesymbol_syn
Call
resolver
uniprot
A2RRK1
resolver
uniprot
Q8BS24
resolver
uniprot
Q8C6W0
resolver
uniprot
Q8C823
resolver
uniprot
Q8VBY7
resolver
uniprot_entry
NCHL1_MOUSE
resolver
uniprot_sec
A2RRK1
resolver
uniprot_sec
Q8BS24
resolver
uniprot_sec
Q8C6W0
resolver
uniprot_sec
Q8C823
resolver
uniprot_sec
Q8VBY7
resolver
amino_acid_sequence
MMELPLCGRGLILSLIFLLLKLSAAEIPLSVQQVPTIVKQSYVQVAFPFDEYFQIECEAKGNPEPIFSWTKDDKPFDLSDPRIIAANNSGTFKIPNEGHISHFQGKYRCFASNRLGTAVSEEIEFIVPGVPKFPKEKIEPIDVEEGDSIVLPCNPPKGLPPLHIYWMNIELEHIEQDERVYMSQRGDLYFANVEENDSRNDYCCFAAFPKLRTIVQKMPMKLTVNSSNSIKQRKPKLLLPPAQMGSLSAKTVLKGDTLLLECFAEGLPTPHIQWSKPGSELPEGRATIEVHEKTLKIENISYQDRGNYRCTANNLLGKASHDFHVTVEEPPRWKKKPQSAVYSTGSSGILLCEAEGEPQPTIKWRLNGLPIEKHPFPGDFMFPREISFTNLLPNHTGVYQCEASNIHGTILANANIDVIDVIPLIKTKNEENYATVVGYSAFLHCEYFASPKATVVWEVADETHPLEGDRYHTHENGTLEIYRTTEEDAGSYSCWVDNAMGKAVITANLDIRNATKLRVSPKNPRIPKSHVLELYCESQCDSHLKHSLKLSWSKDGEAFEMNGTEDGRIVIDGAYLTISNITAEDQGVYSCSAQTSLDSTSEKTQVTVLGVPDPPGNLHLSERQNRSVRLSWEAGDDHNSKISEYIVEFEGNREEPGKWEELTRVQGEETDVVLSLAPYVRYQFRVTAVNEVGRSHASLPSDHHETPPAAPDKNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYKVSWKPQGAPEEWEEEIVTNHTLRVMTPTVYAPYDVKVQAINQLGSSPDPQPVTLYSGEDYPSTAPVIQRVDVMNSTLVKVTWSSIPKETVHGLLRGYQINWWKTKSLLDGRTHPKEVNILRFSGQRNSGMVPSLDPFSEFHLTVLAYNSKGAGPESEPYIFQTPEGVPEQPSFLKVIKVDKDTATLSWGLPKKLNGNLTGYLLQYQIINDTYELGELNEINVTTPSKSSWHLSNLNSTTKYKFYLRACTSRGCGKPISEEGATLGEGSKGIRKITEGVNVTQKIHPVEVLVPGAEHIVHLMTKNWGDNDSIFQDVIETRGREYAGLYDDISTQGWFIGLMCAIALLTLILLTICFVKRNRGGKYSVKEKEDLHPDPEVQSAKDETFGEYSDSDEKPLKGSLRSLNRNMQPTESADSLVEYGEGDQSIFNEDGSFIGAYTGAKEKGSVESNGSSTATFPLRA
uniprot
proteins
function
FUNCTION: Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons as well as in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dependent cell migration towards extracellular matrix proteins. Recruits ANK3 to the plasma membrane. {ECO:0000269|PubMed:10022583, ECO:0000269|PubMed:10103075, ECO:0000269|PubMed:12391163, ECO:0000269|PubMed:12721290, ECO:0000269|PubMed:12812975, ECO:0000269|PubMed:14659567, ECO:0000269|PubMed:14761956, ECO:0000269|PubMed:15504324, ECO:0000269|PubMed:16623841}.
uniprot
proteins
mass_dalton
135074
uniprot
proteins
mutagenesis
MUTAGEN 555..558; /note="DGEA->AGEV: Inhibition of migration potentiation."; /evidence="ECO:0000269|PubMed:12721290"; MUTAGEN 1186; /note="Y->A: Inhibition of migration potentiation."; /evidence="ECO:0000269|PubMed:12721290
uniprot
proteins
post_translational_modification
PTM: Cleavage by metalloprotease ADAM8 in the extracellular part generates 2 soluble forms (125 kDa and 165 kDa) in vitro and is inhibited by metalloprotease inhibitors. In brain extracts, these two soluble forms are also present and are dramatically reduced in mice lacking ADAM8 (PubMed:14761956). Cleaved by BACE1 (PubMed:29325091). {ECO:0000269|PubMed:14761956, ECO:0000269|PubMed:29325091}.; PTM: N-glycosylated. Contains N-linked oligosaccharides with a sulfated carbohydrate structure type HNK-1 (SO4-3-GlcUABeta1,3GalBeta1,4GlcNAc). {ECO:0000269|PubMed:8921253}.; PTM: O-glycosylated. {ECO:0000269|PubMed:8921253}.
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
protein_family
L1/neurofascin/NgCAM family
uniprot
proteins
pubmed
10022583
uniprot
proteins
pubmed
10103075
uniprot
proteins
pubmed
12391163
uniprot
proteins
pubmed
12721290
uniprot
proteins
pubmed
12812975
uniprot
proteins
pubmed
14659567
uniprot
proteins
pubmed
14761956
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15504324
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16623841
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29325091
uniprot
proteins
pubmed
8921253
uniprot
proteins
sequence_length
1209
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note=Soluble forms produced by cleavage/shedding also exist.; SUBCELLULAR LOCATION: [Processed neural cell adhesion molecule L1-like protein]: Secreted, extracellular space, extracellular matrix.
uniprot
proteins
transmembrane_region
TRANSMEM 1084..1104; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins