Nrg1
entrez
211323
canonical
uniprot
Q6DR98
canonical
ensembl
ENSMUSG00000062991
resolver
ensp
ENSMUSP00000073546
resolver
ensp
ENSMUSP00000146456
resolver
ensp
ENSMUSP00000146617
resolver
ensp
ENSMUSP00000146816
resolver
ensp
ENSMUSP00000146905
resolver
ensp
ENSMUSP00000147121
resolver
ensp
ENSMUSP00000147156
resolver
ensp
ENSMUSP00000159071
resolver
ensp
ENSMUSP00000159096
resolver
ensp
ENSMUSP00000159112
resolver
ensp
ENSMUSP00000161905
resolver
ensp
ENSMUSP00000161909
resolver
ensp
ENSMUSP00000161910
resolver
enst
ENSMUST00000073884
resolver
enst
ENSMUST00000207417
resolver
enst
ENSMUST00000207470
resolver
enst
ENSMUST00000208205
resolver
enst
ENSMUST00000208497
resolver
enst
ENSMUST00000209107
resolver
enst
ENSMUST00000238812
resolver
enst
ENSMUST00000238842
resolver
genesymbol
Nrg1
resolver
uniprot
A0A140LHZ9
resolver
uniprot
A0A140LIG9
resolver
uniprot
A0A140LIP8
resolver
uniprot
A0A140LJC1
resolver
uniprot
A0A5F8MPT0
resolver
uniprot
A0A5F8MPT8
resolver
uniprot
F7AKG5
resolver
uniprot
Q6DR99
resolver
uniprot_entry
A0A140LHZ9_MOUSE
resolver
uniprot_entry
A0A140LIG9_MOUSE
resolver
uniprot_entry
A0A140LIP8_MOUSE
resolver
uniprot_entry
A0A140LJC1_MOUSE
resolver
uniprot_entry
A0A5F8MPT0_MOUSE
resolver
uniprot_entry
A0A5F8MPT8_MOUSE
resolver
uniprot_entry
F7AKG5_MOUSE
resolver
uniprot_entry
NRG1_MOUSE
resolver
uniprot_entry
Q6DR99_MOUSE
resolver
amino_acid_sequence
MSERKEGRGKGKGKKKDRGSRGKPAPAEGDPSPALPPRLKEMKSQESAAGSKLVLRCETSSEYSSLRFKWFKNGNELNRRNKPQNVKIQKKPGKSELRINKASLADSGEYMCKVISKLGNDSASANITIVESNDLTTGMSASTERPYVSSESPIRISVSTEGANTSSSTSTSTTGTSHLIKCAEKEKTFCVNGGECFMVKDLSNPSRYLCKCPNEFTGDRCQNYVMASFYKHLGIEFMEAEELYQKRVLTITGICIALLVVGIMCVVAYCKTKKQRQKLHDRLRQSLRSERNNMVNIANGPHHPNPPPENVQLVNQYVSKNVISSEHIVEREVETSFSTSHYTSTAHHSTTVTQTPSHSWSNGHTESIISESHSVIMMSSVENSRHSSPAGGPRGRLHGLGGPRECNSFLRHARETPDSYRDSPHSERYVSAMTTPARMSPVDFHTPSSPKSPPSEMSPPVSSMTVSMPSVAVSPFVEEERPLLLVTPPRLREKKYDHHPQQLNSFHHNPAHQSTSLPPSPLRIVEDEEYETTQEYEPIQEPIKKVTNSRRAKRTKPNGHIANRLEMDSNPSSVSSNSESETEDERVGEDTPFLGIQNPLAASLEVAPAFRLAESRTNPAGRFSTQEELQARLSSVIANQDPIAV
uniprot
proteins
function
FUNCTION: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Binds to ERBB4 and ERBB3. Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling (By similarity). Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1, and ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons (By similarity). {ECO:0000250|UniProtKB:P43322, ECO:0000250|UniProtKB:Q02297}.
uniprot
proteins
mass_dalton
71382
uniprot
proteins
post_translational_modification
PTM: Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. {ECO:0000250|UniProtKB:Q02297}.; PTM: N- and O-glycosylated. Extensive glycosylation precedes the proteolytic cleavage (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Neuregulin family
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19935654
uniprot
proteins
sequence_length
645
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Pro-neuregulin-1, membrane-bound isoform]: Cell membrane {ECO:0000250|UniProtKB:Q02297}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q02297}. Note=Does not seem to be active. {ECO:0000250|UniProtKB:Q02297}.; SUBCELLULAR LOCATION: [Neuregulin-1]: Secreted {ECO:0000250|UniProtKB:Q02297}.
uniprot
proteins
transmembrane_region
TRANSMEM 248..268; /note="Helical; Note=Internal signal sequence"; /evidence="ECO:0000255
uniprot
proteins