Lancl1
entrez
14768
canonical
uniprot
O89112
canonical
ensembl
ENSMUSG00000026000
resolver
ensp
ENSMUSP00000027149
resolver
ensp
ENSMUSP00000109612
resolver
ensp
ENSMUSP00000113080
resolver
enst
ENSMUST00000027149
resolver
enst
ENSMUST00000113979
resolver
enst
ENSMUST00000119559
resolver
genesymbol
Lancl1
resolver
genesymbol_syn
Gpr69a
resolver
uniprot_entry
LANC1_MOUSE
resolver
amino_acid_sequence
MAQRAFPNPYADYNKSLAENYFDSTGRLTPEFSHRLTNKIRELLQQMERGLKSADPRDGTGYTGWAGIAVLYLHLHNVFGDPAYLQMAHSYVKQSLNCLSRRSITFLCGDAGPLAVAAVLYHKMNSEKQAEECITRLIHLNKIDPHVPNEMLYGRIGYIFALLFVNKNFGEEKIPQSHIQQICENILTSGENLSRKRNLAAKSPLMYEWYQEYYVGAAHGLAGIYYYLMQPSLQVNQGKLHSLVKPSVDFVCRLKFPSGNYPPCLDDTRDLLVHWCHGAPGVIYMLIQAYKVFKEERYLCDAQQCADVIWQYGLLKKGYGLCHGAAGNAYAFLALYNLTQDLKYLYRACKFAEWCLDYGEHGCRTADTPFSLFEGMAGTIYFLADLLVPTKAKFPAFEL
uniprot
proteins
ec_number
2.5.1.18
uniprot
proteins
function
FUNCTION: Functions as a glutathione transferase (PubMed:25158856). Catalyzes conjugation of the glutathione (GSH) to artificial substrates 1-chloro-2,4-dinitrobenzene (CDNB) and p-nitrophenyl acetate (PubMed:25158856). Mitigates neuronal oxidative stress during normal postnatal development and in response to oxidative stresses probably through GSH antioxidant defense mechanism (PubMed:25158856). May play a role in EPS8 signaling. Binds glutathione (By similarity). {ECO:0000250|UniProtKB:O43813, ECO:0000269|PubMed:25158856}.
uniprot
proteins
mass_dalton
45341
uniprot
proteins
mutagenesis
MUTAGEN 4; /note="R->A: Does not increase glutathione transferase activity and reduces cellular protection."; /evidence="ECO:0000269|PubMed:25158856
uniprot
proteins
protein_family
LanC-like protein family
uniprot
proteins
pubmed
11474189
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17305318
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25158856
uniprot
proteins
pubmed
9714732
uniprot
proteins
sequence_length
399
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O43813}. Cell membrane {ECO:0000250|UniProtKB:O43813}; Peripheral membrane protein {ECO:0000250|UniProtKB:O43813}.
uniprot
proteins