SELENBP1
entrez
8991
canonical
uniprot
Q13228
canonical
ensembl
ENSG00000143416
resolver
ensp
ENSP00000357861
resolver
ensp
ENSP00000397261
resolver
ensp
ENSP00000413960
resolver
ensp
ENSP00000715744
resolver
genesymbol
HEL-S-134P
resolver
genesymbol
SELENBP1
resolver
genesymbol_syn
SBP
resolver
hgnc
HGNC:10719
resolver
uniprot
A6NML9
resolver
uniprot
A6PVW9
resolver
uniprot
B2RDR3
resolver
uniprot
B4DKP6
resolver
uniprot
B4E1F3
resolver
uniprot
Q49AQ8
resolver
uniprot
Q96GX7
resolver
uniprot
V9HWG1
resolver
uniprot_entry
SBP1_HUMAN
resolver
uniprot_entry
V9HWG1_HUMAN
resolver
uniprot_sec
A6NML9
resolver
uniprot_sec
A6PVW9
resolver
uniprot_sec
B2RDR3
resolver
uniprot_sec
B4DKP6
resolver
uniprot_sec
B4E1F3
resolver
uniprot_sec
Q49AQ8
resolver
uniprot_sec
Q96GX7
resolver
amino_acid_sequence
MATKCGNCGPGYSTPLEAMKGPREEIVYLPCIYRNTGTEAPDYLATVDVDPKSPQYCQVIHRLPMPNLKDELHHSGWNTCSSCFGDSTKSRTKLVLPSLISSRIYVVDVGSEPRAPKLHKVIEPKDIHAKCELAFLHTSHCLASGEVMISSLGDVKGNGKGGFVLLDGETFEVKGTWERPGGAAPLGYDFWYQPRHNVMISTEWAAPNVLRDGFNPADVEAGLYGSHLYVWDWQRHEIVQTLSLKDGLIPLEIRFLHNPDAAQGFVGCALSSTIQRFYKNEGGTWSVEKVIQVPPKKVKGWLLPEMPGLITDILLSLDDRFLYFSNWLHGDLRQYDISDPQRPRLTGQLFLGGSIVKGGPVQVLEDEELKSQPEPLVVKGKRVAGGPQMIQLSLDGKRLYITTSLYSAWDKQFYPDLIREGSVMLQVDVDTVKGGLKLNPNFLVDFGKEPLGPALAHELRYPGGDCSSDIWI
uniprot
proteins
disease_involvement
DISEASE: Extraoral halitosis due to methanethiol oxidase deficiency (EHMTO) [MIM:618148]: An autosomal recessive malodor condition characterized by extraoral blood-borne halitosis resulting from the accumulation of sulfur-containing metabolites. In extraoral blood-borne halitosis, malodorant compounds are carried to the lungs, where they enter the breath. Affected individuals have a cabbage-like breath odor, high levels of methanethiol and dimethylsulfide in oral and nasal breath, and elevated urinary excretion of dimethylsulfoxide in the absence of intake of dimethylsulfide-containing food or use of sulfur-containing medication, lower-gastrointestinal problems, and known metabolic defects, such as methionine adenosyltransferase deficiency and tyrosinemia. {ECO:0000269|PubMed:29255262}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
1.8.3.4
uniprot
proteins
function
FUNCTION: Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria (PubMed:29255262). Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport (By similarity). {ECO:0000250|UniProtKB:Q8VIF7, ECO:0000269|PubMed:29255262}.
uniprot
proteins
mass_dalton
52391
uniprot
proteins
pathway_participation
PATHWAY: Organosulfur degradation. {ECO:0000269|PubMed:29255262}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000305|PubMed:14991897}.; PTM: The N-terminus is blocked. {ECO:0000250}.
uniprot
proteins
protein_family
Selenium-binding protein family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14991897
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16223876
uniprot
proteins
pubmed
16380993
uniprot
proteins
pubmed
16645984
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19118533
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29255262
uniprot
proteins
pubmed
9027582
uniprot
proteins
pubmed
9679983
uniprot
proteins
sequence_length
472
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14991897}. Cytoplasm, cytosol {ECO:0000269|PubMed:14991897, ECO:0000269|PubMed:16223876}. Membrane {ECO:0000250|UniProtKB:Q8VIF7}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8VIF7}. Note=May associate with Golgi membrane (By similarity). May associate with the membrane of autophagosomes (By similarity). {ECO:0000250|UniProtKB:Q8VIF7}.
uniprot
proteins