RCN3
entrez
57333
canonical
uniprot
Q96D15
canonical
ensembl
ENSG00000142552
resolver
ensp
ENSP00000270645
resolver
ensp
ENSP00000562700
resolver
ensp
ENSP00000562702
resolver
ensp
ENSP00000603757
resolver
ensp
ENSP00000626928
resolver
ensp
ENSP00000626929
resolver
ensp
ENSP00000626931
resolver
enst
ENST00000270645
resolver
enst
ENST00000892643
resolver
enst
ENST00000933698
resolver
enst
ENST00000956872
resolver
genesymbol
RCN3
resolver
hgnc
HGNC:21145
resolver
uniprot
Q9HBZ8
resolver
uniprot_entry
RCN3_HUMAN
resolver
uniprot_sec
Q9HBZ8
resolver
amino_acid_sequence
MMWRPSVLLLLLLLRHGAQGKPSPDAGPHGQGRVHQAAPLSDAPHDDAHGNFQYDHEAFLGREVAKEFDQLTPEESQARLGRIVDRMDRAGDGDGWVSLAELRAWIAHTQQRHIRDSVSAAWDTYDTDRDGRVGWEELRNATYGHYAPGEEFHDVEDAETYKKMLARDERRFRVADQDGDSMATREELTAFLHPEEFPHMRDIVIAETLEDLDRNKDGYVQVEEYIADLYSAEPGEEEPAWVQTERQQFRDFRDLNKDGHLDGSEVGHWVLPPAQDQPLVEANHLLHESDTDKDGRLSKAEILGNWNMFVGSQATNYGEDLTRHHDEL
uniprot
proteins
function
FUNCTION: Probable molecular chaperone assisting protein biosynthesis and transport in the endoplasmic reticulum (PubMed:16433634, PubMed:28939891). Required for the proper biosynthesis and transport of pulmonary surfactant-associated protein A/SP-A, pulmonary surfactant-associated protein D/SP-D and the lipid transporter ABCA3 (By similarity). By regulating both the proper expression and the degradation through the endoplasmic reticulum-associated protein degradation pathway of these proteins plays a crucial role in pulmonary surfactant homeostasis (By similarity). Has an anti-fibrotic activity by negatively regulating the secretion of type I and type III collagens (PubMed:28939891). This calcium-binding protein also transiently associates with immature PCSK6 and regulates its secretion (PubMed:16433634). {ECO:0000250|UniProtKB:Q8BH97, ECO:0000269|PubMed:16433634, ECO:0000269|PubMed:28939891}.
uniprot
proteins
mass_dalton
37493
uniprot
proteins
mutagenesis
MUTAGEN 86; /note="R->K: Decreased function in PCSK6 maturation and/or secretion."; /evidence="ECO:0000269|PubMed:16433634"; MUTAGEN 112; /note="R->K: Decreased function in PCSK6 maturation and/or secretion."; /evidence="ECO:0000269|PubMed:16433634"; MUTAGEN 325..328; /note="Missing: Decreased function in PCSK6 maturation and/or secretion."; /evidence="ECO:0000269|PubMed:16433634
uniprot
proteins
post_translational_modification
PTM: Degraded by PCSK6 and other endoproteases including FURIN and PCSK5. {ECO:0000269|PubMed:16433634}.; PTM: N-glycosylated. {ECO:0000250|UniProtKB:I6L9G5}.
uniprot
proteins
protein_family
CREC family
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16433634
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
28939891
uniprot
proteins
sequence_length
328
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:16433634}.
uniprot
proteins