Q8BM65
uniprot
Q8BM65
canonical
amino_acid_sequence
MIPSKMMSANPEEDPLDTFFQYIEDMGMKAYDGLVIQNASDIARENDRLRNETKLAYLKEKNEKRRRQEETIKRIGGEVGRGQDASYAGKHFRMGFMTMPAPQDRLPHPCSSGFTVRSQSLHSVGGTEDDSSCGSRRQPPPKPKRDPSTKLSTSSETVNSTAASKSGRSLERAEGKFTVPASHSPPRASTSGHLFPSPGSQERNIKVSAKPRPHSDEYSKKIPPPKPKRNPNTQLSTSFDETYIKKHVPRRTSLPRDSSLSQVCSPAADPEEEEPVYIEMVGNILRDFRKEEDDQSEAVYEEMKYPIFDDLGHDSKCDFDHHSCSSQCATPTVPDLDFVKSSGPCTPKGLLCDIPPPFPNLLSHRPPLLVFPPAPVHCSPNSDESPLTPLEVTKLPVLENVSYMKQPPGACPSSLPSHGSSHAKDQTGALGPAPGASILSSSPPPPSTLYRTQSPHGYPKSHSTSPSPVSMGRSLTPLSLKRPPPYDAVHSGSLSRSSSSVPHTTPRPVSQDGAKMVNAAVNTYSAAQSGSRSRTPTSPLEELTSLFTSGRSLLRKSSSGRRSKEPAEKSTEELKVRSHSTEPLPKLDSKERGHYGSSSSREPVKAQEWDGTPGPPVVTSRMGRCSVSPTLLAGNHSSEPKVSCKLGRSASTSGVPPPSVTPLRQASDLQQSQVPSSLANRD
uniprot
proteins
function
FUNCTION: Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis. {ECO:0000269|PubMed:21946561}.
uniprot
proteins
mass_dalton
73897
uniprot
proteins
mutagenesis
MUTAGEN 277; /note="Y->F: Abolishes binding to PIK3R2. Slight reduction of phosphorylation in HEK293T cells. Abolishes phosphorylation in HEK293T cells and in neurons; when associated with F-300."; /evidence="ECO:0000269|PubMed:21946561"; MUTAGEN 300; /note="Y->F: Reduced binding to PIK3R2. Slight reduction of phosphorylation in HEK293T cells. Abolishes phosphorylation in HEK293T cells and neurons; when associated with F-277."; /evidence="ECO:0000269|PubMed:21946561
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues by FYN upon stimulation with CNTN5. Phosphorylation begins at 16 dpc and persists in adult brain. {ECO:0000269|PubMed:21946561}.
uniprot
proteins
protein_family
NYAP family
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21946561
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
682
uniprot
proteins