GPR183
entrez
1880
canonical
uniprot
P32249
canonical
ensembl
ENSG00000169508
resolver
ensp
ENSP00000365596
resolver
ensp
ENSP00000528964
resolver
enst
ENST00000376414
resolver
enst
ENST00000858905
resolver
genesymbol
GPR183
resolver
genesymbol_syn
EBI2
resolver
hgnc
HGNC:3128
resolver
uniprot
B2R8N5
resolver
uniprot
Q53F99
resolver
uniprot
Q5JUH7
resolver
uniprot_entry
GP183_HUMAN
resolver
uniprot_sec
B2R8N5
resolver
uniprot_sec
Q53F99
resolver
uniprot_sec
Q5JUH7
resolver
amino_acid_sequence
MDIQMANNFTPPSATPQGNDCDLYAHHSTARIVMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSTNLVISDILFTTALPTRIAYYAMGFDWRIGDALCRITALVFYINTYAGVNFMTCLSIDRFIAVVHPLRYNKIKRIEHAKGVCIFVWILVFAQTLPLLINPMSKQEAERITCMEYPNFEETKSLPWILLGACFIGYVLPLIIILICYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIVVFVLCFTPYHVAIIQHMIKKLRFSNFLECSQRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMRMLKRQVSVSISSAVKSAPEENSREMTETQMMIHSKSSNGK
uniprot
proteins
function
FUNCTION: G protein-coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (By similarity). Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (PubMed:21796212, PubMed:22875855, PubMed:22930711). Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient (By similarity). Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses (By similarity). Guides B-cell movement along the B-cell zone-T-cell zone boundary and later to interfollicular and outer follicular regions (By similarity). Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Collaborates with CXCR5 to mediate B-cell migration; probably by forming a heterodimer with CXCR5 that affects the interaction between of CXCL13 and CXCR5 (PubMed:22913878). Also acts as a chemotactic receptor for some T-cells upon binding to 7-alpha,25-OHC ligand (By similarity). Promotes follicular helper T (Tfh) cells differentiation by positioning activated T-cells at the follicle-T-zone interface, promoting contact of newly activated CD4 T-cells with activated dendritic cells and exposing them to Tfh-cell-promoting inducible costimulator (ICOS) ligand (By similarity). Expression in splenic dendritic cells is required for their homeostasis, localization and ability to induce B- and T-cell responses: GPR183 acts as a chemotactic receptor in dendritic cells that mediates the accumulation of CD4(+) dendritic cells in bridging channels (By similarity). Regulates migration of astrocytes and is involved in communication between astrocytes and macrophages (PubMed:25297897). Promotes osteoclast precursor migration to bone surfaces (By similarity). Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha (PubMed:21673108, PubMed:25297897). Signals constitutively also via MAPK1/3 (ERK1/2) (By similarity). {ECO:0000250|UniProtKB:Q3U6B2, ECO:0000269|PubMed:16540462, ECO:0000269|PubMed:21673108, ECO:0000269|PubMed:21796212, ECO:0000269|PubMed:22875855, ECO:0000269|PubMed:22913878, ECO:0000269|PubMed:22930711, ECO:0000269|PubMed:25297897}.
uniprot
proteins
mass_dalton
41224
uniprot
proteins
mutagenesis
MUTAGEN 21; /note="C->A: Strongly reduced localization to the cell membrane and reduced protein expression levels."; /evidence="ECO:0000269|PubMed:22930711"; MUTAGEN 77; /note="D->A: Loss of receptor activation without affecting oxysterol agonist-binding."; /evidence="ECO:0000269|PubMed:22875855, ECO:0000269|PubMed:22930711"; MUTAGEN 77; /note="D->R: Strong decrease in oxysterol agonist-binding and receptor activation."; /evidence="ECO:0000269|PubMed:22875855"; MUTAGEN 85; /note="P->A: Strongly reduced localization to the cell membrane."; /evidence="ECO:0000269|PubMed:22930711"; MUTAGEN 87; /note="R->A: Strong decrease in oxysterol agonist-binding and receptor activation."; /evidence="ECO:0000269|PubMed:18628402, ECO:0000269|PubMed:22875855, ECO:0000269|PubMed:22930711"; MUTAGEN 87; /note="R->K: Slight decrease in oxysterol agonist-binding and receptor activation."; /evidence="ECO:0000269|PubMed:18628402, ECO:0000269|PubMed:22875855"; MUTAGEN 87; /note="R->W: Slight decrease in oxysterol agonist-binding and receptor activation."; /evidence="ECO:0000269|PubMed:22930711"; MUTAGEN 90; /note="Y->A: 10-fold reduction in receptor activation. Strongly reduced localization to the cell membrane."; /evidence="ECO:0000269|PubMed:22875855, ECO:0000269|PubMed:22930711"; MUTAGEN 104; /note="C->A: Abolishes localization to the cell membrane without affecting protein expression levels."; /evidence="ECO:0000269|PubMed:22930711"; MUTAGEN 111; /note="F->A,Y: 500-fold decrease of IC(50) for GSK682753A. No effect on oxysterol agonist-binding and receptor activation."; /evidence="ECO:0000269|PubMed:21673108, ECO:0000269|PubMed:22875855"; MUTAGEN 112; /note="Y->A,F: Strong decrease in oxysterol agonist-binding and receptor activation."; /evidence="ECO:0000269|PubMed:22875855, ECO:0000269|PubMed:22930711"; MUTAGEN 114; /note="N->A: Strongly reduced localization to the cell membrane."; /evidence="ECO:0000269|PubMed:22930711"; MUTAGEN 115; /note="T->A,F: No effect."; /evidence="ECO:0000269|PubMed:22875855"; MUTAGEN 116; /note="Y->A,F: Strong decrease in oxysterol agonist-binding and receptor activation."; /evidence="ECO:0000269|PubMed:22875855, ECO:0000269|PubMed:22930711"; MUTAGEN 181; /note="C->A: Abolishes localization to the cell membrane without affecting protein expression levels."; /evidence="ECO:0000269|PubMed:22930711"; MUTAGEN 183; /note="E->A: Strong reduction in ligand potency."; /evidence="ECO:0000269|PubMed:22930711"; MUTAGEN 197; /note="L->A: Reduced localization to the cell membrane and reduced receptor function."; /evidence="ECO:0000269|PubMed:22930711"; MUTAGEN 205; /note="Y->A,F: No effect."; /evidence="ECO:0000269|PubMed:22875855"; MUTAGEN 256; /note="C->A: Increased receptor activation."; /evidence="ECO:0000269|PubMed:18628402"; MUTAGEN 257; /note="F->A: Increased receptor activation. Strongly reduced localization to the cell membrane."; /evidence="ECO:0000269|PubMed:18628402, ECO:0000269|PubMed:22930711"; MUTAGEN 260; /note="Y->A,F: Strong decrease in oxysterol agonist-binding and receptor activation."; /evidence="ECO:0000269|PubMed:22875855, ECO:0000269|PubMed:22930711"; MUTAGEN 261; /note="H->A: Reduced localization to the cell membrane and reduced receptor function."; /evidence="ECO:0000269|PubMed:22930711"; MUTAGEN 264; /note="I->A: Reduced localization to the cell membrane and reduced receptor function."; /evidence="ECO:0000269|PubMed:22930711"; MUTAGEN 280; /note="C->A: Strongly reduced localization to the cell membrane and reduced protein expression levels."; /evidence="ECO:0000269|PubMed:22930711"; MUTAGEN 287; /note="Q->A: 10-fold reduction in receptor activation."; /evidence="ECO:0000269|PubMed:22875855"; MUTAGEN 291; /note="H->A: 10-fold reduction in receptor activation."; /evidence="ECO:0000269|PubMed:22875855"; MUTAGEN 291; /note="H->A: Reduced localization to the cell membrane and reduced receptor function."; /evidence="ECO:0000269|PubMed:22930711"; MUTAGEN 294; /note="V->A: Reduced localization to the cell membrane and reduced receptor function."; /evidence="ECO:0000269|PubMed:22930711"; MUTAGEN 297; /note="M->A: Reduced localization to the cell membrane and reduced receptor function, without affecting oxysterol agonist-binding."; /evidence="ECO:0000269|PubMed:22930711"; MUTAGEN 297; /note="M->I: Reduced localization to the cell membrane and reduced receptor function. Reduced oxysterol agonist-binding."; /evidence="ECO:0000269|PubMed:22930711
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16540462
uniprot
proteins
pubmed
18628402
uniprot
proteins
pubmed
18987736
uniprot
proteins
pubmed
21673108
uniprot
proteins
pubmed
21796212
uniprot
proteins
pubmed
22875855
uniprot
proteins
pubmed
22913878
uniprot
proteins
pubmed
22930711
uniprot
proteins
pubmed
23772388
uniprot
proteins
pubmed
24678947
uniprot
proteins
pubmed
25297897
uniprot
proteins
pubmed
8383238
uniprot
proteins
sequence_length
361
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16540462, ECO:0000269|PubMed:18628402, ECO:0000269|PubMed:21673108, ECO:0000269|PubMed:22930711}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..57; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 78..95; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 106..127; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 150..168; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 193..215; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 242..265; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 288..312; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins