Bex3
entrez
12070
canonical
uniprot
Q9WTZ9
canonical
ensembl
ENSMUSG00000046432
resolver
ensp
ENSMUSP00000063039
resolver
ensp
ENSMUSP00000108737
resolver
ensp
ENSMUSP00000136952
resolver
genesymbol
Bex3
resolver
genesymbol_syn
Nade
resolver
genesymbol_syn
Ngfrap1
resolver
uniprot
A3KGA0
resolver
uniprot
A3KGA1
resolver
uniprot
Q9CWN9
resolver
uniprot
Q9D0S2
resolver
uniprot
Q9D1N5
resolver
uniprot_entry
BEX3_MOUSE
resolver
uniprot_sec
A3KGA0
resolver
uniprot_sec
A3KGA1
resolver
uniprot_sec
Q9CWN9
resolver
uniprot_sec
Q9D0S2
resolver
uniprot_sec
Q9D1N5
resolver
amino_acid_sequence
MANVHQENEEMEQPLQNGQEDRPVGGGEGHQPAANNNNNNHNHNHNHHRRGQARRLAPNFRWAIPNRQMNDGLGGDGDDMEMFMEEMREIRRKLRELQLRNCLRILMGELSNHHDHHDEFCLMP
uniprot
proteins
function
FUNCTION: May be a signaling adapter molecule involved in NGFR/p75NTR-mediated apoptosis induced by NGF (PubMed:10764727). Plays a role in zinc-triggered neuronal death (PubMed:10764727). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (PubMed:34562363). {ECO:0000269|PubMed:10764727, ECO:0000269|PubMed:34562363}.
uniprot
proteins
mass_dalton
14542
uniprot
proteins
mutagenesis
MUTAGEN 94; /note="L->A: Abolishes nuclear export and interactions with itself and p75NTR/NGFR; when associated with A-97 and A-99."; /evidence="ECO:0000269|PubMed:11830582"; MUTAGEN 97; /note="L->A: Abolishes nuclear export and interactions with itself and p75NTR/NGFR; when associated with A-97 and A-99."; /evidence="ECO:0000269|PubMed:11830582"; MUTAGEN 99; /note="L->A: Abolishes nuclear export and interactions with itself and p75NTR/NGFR; when associated with A-94 and A-97."; /evidence="ECO:0000269|PubMed:11830582"; MUTAGEN 113..117; /note="HHDHH->AADAA: Abolished zinc-binding and association with FEM1B."; /evidence="ECO:0000269|PubMed:34562363"; MUTAGEN 121; /note="C->A: Abolishes localization with replicating mitochondria."; /evidence="ECO:0000269|PubMed:15563833"; MUTAGEN 121; /note="C->S: Abolished zinc-binding and association with FEM1B."; /evidence="ECO:0000269|PubMed:34562363
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated (PubMed:10764727). Degraded by the proteasome (PubMed:10764727). {ECO:0000269|PubMed:10764727, ECO:0000305}.
uniprot
proteins
protein_family
BEX family
uniprot
proteins
pubmed
10072429
uniprot
proteins
pubmed
10764727
uniprot
proteins
pubmed
11278287
uniprot
proteins
pubmed
11830582
uniprot
proteins
pubmed
12935912
uniprot
proteins
pubmed
15178455
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15563833
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
34562363
uniprot
proteins
sequence_length
124
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11830582}. Cytoplasm, cytosol {ECO:0000269|PubMed:10764727, ECO:0000269|PubMed:11830582}. Note=Shuttles between the cytoplasm and the nucleus (PubMed:11830582). Associates with replicating mitochondria (PubMed:15563833). {ECO:0000269|PubMed:11830582, ECO:0000269|PubMed:15563833}.
uniprot
proteins