FCN3
entrez
8547
canonical
uniprot
O75636
canonical
ensembl
ENSG00000142748
resolver
ensp
ENSP00000270879
resolver
ensp
ENSP00000347077
resolver
genesymbol
FCN3
resolver
genesymbol_syn
FCNH
resolver
genesymbol_syn
HAKA1
resolver
hgnc
HGNC:3625
resolver
uniprot
Q6IBJ5
resolver
uniprot
Q6UXM4
resolver
uniprot
Q8WW86
resolver
uniprot_entry
FCN3_HUMAN
resolver
uniprot_entry
Q6UXM4_HUMAN
resolver
uniprot_sec
Q6IBJ5
resolver
uniprot_sec
Q8WW86
resolver
amino_acid_sequence
MDLLWILPSLWLLLLGGPACLKTQEHPSCPGPRELEASKVVLLPSCPGAPGSPGEKGAPGPQGPPGPPGKMGPKGEPGDPVNLLRCQEGPRNCRELLSQGATLSGWYHLCLPEGRALPVFCDMDTEGGGWLVFQRRQDGSVDFFRSWSSYRAGFGNQESEFWLGNENLHQLTLQGNWELRVELEDFNGNRTFAHYATFRLLGEVDHYQLALGKFSEGTAGDSLSLHSGRPFTTYDADHDSSNSNCAVIVHGAWWYASCYRSNLNGRYAVSEAAAHKYGIDWASGRGVGHPYRRVRMMLR
uniprot
proteins
disease_involvement
DISEASE: Ficolin 3 deficiency (FCN3D) [MIM:613860]: A disorder characterized by immunodeficiency, recurrent infections, brain abscesses and recurrent warts on the fingers. Affected individuals have normal levels of lymphocytes, normal T-cell responses, and normal antibodies, but a selective deficient antibody response to pneumococcal polysaccharide vaccine. {ECO:0000269|PubMed:19535802}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:11907111, PubMed:15804047, PubMed:17215869, PubMed:26133042). Specifically recognizes and binds carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway (PubMed:15804047, PubMed:17215869, PubMed:26133042). Specifically binds N-Acetylglucosamine (GlcNAc,) GalNAc (N-acetylgalactosamine) and D-fucose on the surface of pathogens, as well as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota (PubMed:17215869). {ECO:0000269|PubMed:11907111, ECO:0000269|PubMed:15804047, ECO:0000269|PubMed:17215869, ECO:0000269|PubMed:26133042}.
uniprot
proteins
mass_dalton
32903
uniprot
proteins
post_translational_modification
PTM: The N-terminus is blocked. {ECO:0000269|PubMed:9694814}.
uniprot
proteins
protein_family
Ficolin lectin family
uniprot
proteins
pubmed
10330454
uniprot
proteins
pubmed
11907111
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15804047
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17215869
uniprot
proteins
pubmed
19139490
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19535802
uniprot
proteins
pubmed
26133042
uniprot
proteins
pubmed
9694814
uniprot
proteins
sequence_length
299
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:9694814}. Cell surface {ECO:0000269|PubMed:26133042}. Note=Specifically binds carbohydrates on the surface of pathogens. {ECO:0000269|PubMed:26133042}.
uniprot
proteins