Kcnk13
entrez
64120
canonical
uniprot
Q9ERS0
canonical
ensembl
ENSRNOG00000047363
resolver
ensp
ENSRNOP00000067310
resolver
ensp
ENSRNOP00000101877
resolver
enst
ENSRNOT00000075794
resolver
enst
ENSRNOT00000143210
resolver
genesymbol
Kcnk13
resolver
uniprot
M0RCJ1
resolver
uniprot_entry
KCNKD_RAT
resolver
uniprot_entry
M0RCJ1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by anionic lipids (By similarity). Activated by arachidonic acid (PubMed:11060316). Inhibited by Ba(2+) ions, volatile anesthetics such as halothane and weakly inhibited by extracellular acidification to pH 6 (PubMed:11060316). {ECO:0000250|UniProtKB:Q9HB14, ECO:0000269|PubMed:11060316}.
uniprot
proteins
amino_acid_sequence
MAGRGCSCSPGHLNEDNARFLLLAGLILLYLLGGAAVFSALELAQELQAKQRWEERLANFSRGHNLSREELRGFLRHYEEATKAGIRMDSVRPRWDFTGAFYFVGTVVTTIGFGMTTPATTGGKVFLIFYGLIGCASTILFFNLFLERLITVIAYVMRTCHHQQLRRRGTVARDNRKAPRKGEADSLAGWKPSVYYVMLILCLASVAISCGASALYTTMEGWSYFDSVYFCFVASSTIGFGDLVSSQNAQYENEGLYRFVNFFFILMGVCCIYSMFNVISILIKQTVNWILRKLDSGCFPQCQRGLLRSRRNVVMPGNIRNRCNISIETDGVMESDTDGRRLSGEMISMKDTNKVSLAILQKQLSEMANGGPHQTSTSSRDDEFSGGVGAFAVMNNRLAETSGDR
uniprot
proteins
function
FUNCTION: K(+) channel that conducts outward rectifying tonic currents potentiated by purinergic signals (PubMed:11060316). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (By similarity). Contributes most of K(+) currents at the plasma membrane of resting microglia (By similarity). Maintains a depolarized membrane potential required for proper ramified microglia morphology and phagocytosis, selectively mediating microglial pruning of presynaptic compartments at hippocampal excitatory synapses (By similarity). Upon local release of ATP caused by neuronal injury or infection, it is potentiated by P2RY12 and P2RX7 receptor signaling and contributes to ATP-triggered K(+) efflux underlying microglial NLRP3 inflammasome assembly and IL1B release (By similarity). {ECO:0000250|UniProtKB:Q9HB14, ECO:0000269|PubMed:11060316}.
uniprot
proteins
mass_dalton
45081
uniprot
proteins
protein_family
Two pore domain potassium channel (TC 1.A.1.8) family
uniprot
proteins
pubmed
11060316
uniprot
proteins
sequence_length
405
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11060316}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9HB14}.
uniprot
proteins
transmembrane_region
TRANSMEM 20..41; /note="Helical; Name=M1"; /evidence="ECO:0000250|UniProtKB:Q9HB14"; TRANSMEM 125..145; /note="Helical; Name=M2"; /evidence="ECO:0000250|UniProtKB:Q9HB14"; TRANSMEM 197..217; /note="Helical; Name=M3"; /evidence="ECO:0000250|UniProtKB:Q9HB14"; TRANSMEM 259..279; /note="Helical; Name=M4"; /evidence="ECO:0000250|UniProtKB:Q9HB14
uniprot
proteins