Lgals3
entrez
83781
canonical
uniprot
P08699
canonical
ensembl
ENSRNOG00000010645
resolver
ensp
ENSRNOP00000014216
resolver
ensp
ENSRNOP00000070203
resolver
genesymbol
Lgals3
resolver
uniprot
A6KE45
resolver
uniprot
V5QQP9
resolver
uniprot_entry
A6KE45_RAT
resolver
uniprot_entry
LEG3_RAT
resolver
uniprot_sec
V5QQP9
resolver
amino_acid_sequence
MADGFSLNDALAGSGNPNPQGWPGAWGNQPGAGGYPGASYPGAYPGQAPPGGYPGQAPPSAYPGPTGPSAYPGPTAPGAYPGPTAPGAFPGQPGGPGAYPSAPGAYPSAPGAYPATGPFGAPTGPLTVPYDMPLPGGVMPRMLITIIGTVKPNANSITLNFKKGNDIAFHFNPRFNENNRRVIVCNTKQDNNWGREERQSAFPFESGKPFKIQVLVEADHFKVAVNDVHLLQYNHRMKNLREISQLGIIGDITLTSASHAMI
uniprot
proteins
function
FUNCTION: Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells. Together with TRIM16, coordinates the recognition of membrane damage with mobilization of the core autophagy regulators ATG16L1 and BECN1 in response to damaged endomembranes (By similarity). Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (PubMed:11121438). When secreted, interacts with NK cell-activating receptor NCR3/NKp30 acting as an inhibitory ligand which antagonizes NK cell attack (By similarity). {ECO:0000250|UniProtKB:P17931, ECO:0000269|PubMed:11121438}.
uniprot
proteins
mass_dalton
27202
uniprot
proteins
pubmed
11121438
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15729693
uniprot
proteins
pubmed
2605254
uniprot
proteins
pubmed
2958848
uniprot
proteins
pubmed
3858867
uniprot
proteins
pubmed
8253805
uniprot
proteins
sequence_length
262
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P17931}. Nucleus {ECO:0000250|UniProtKB:P17931}. Secreted {ECO:0000250|UniProtKB:P17931}. Note=Secreted by a non-classical secretory pathway and associates with the cell surface. Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. {ECO:0000250|UniProtKB:P17931}.
uniprot
proteins