RASSF7
entrez
8045
canonical
uniprot
Q02833
canonical
ensembl
ENSG00000099849
resolver
ensembl
ENSG00000273859
resolver
ensp
ENSP00000380712
resolver
ensp
ENSP00000380713
resolver
ensp
ENSP00000405606
resolver
ensp
ENSP00000479652
resolver
enst
ENST00000622905
resolver
genesymbol
RASSF7
resolver
genesymbol_syn
C11orf13
resolver
genesymbol_syn
HRC1
resolver
hgnc
HGNC:1166
resolver
uniprot
G5E9N9
resolver
uniprot
Q3KP41
resolver
uniprot
Q3KP42
resolver
uniprot_entry
RASF7_HUMAN
resolver
uniprot_sec
G5E9N9
resolver
uniprot_sec
Q3KP41
resolver
uniprot_sec
Q3KP42
resolver
amino_acid_sequence
MLLGLAAMELKVWVDGIQRVVCGVSEQTTCQEVVIALAQAIGQTGRFVLVQRLREKERQLLPQECPVGAQATCGQFASDVQFVLRRTGPSLAGRPSSDSCPPPERCLIRASLPVKPRAALGCEPRKTLTPEPAPSLSRPGPAAPVTPTPGCCTDLRGLELRVQRNAEELGHEAFWEQELRREQAREREGQARLQALSAATAEHAARLQALDAQARALEAELQLAAEAPGPPSPMASATERLHQDLAVQERQSAEVQGSLALVSRALEAAERALQAQAQELEELNRELRQCNLQQFIQQTGAALPPPPRPDRGPPGTQGPLPPAREESLLGAPSESHAGAQPRPRGGPHDAELLEVAAAPAPEWCPLAAQPQAL
uniprot
proteins
function
FUNCTION: Negatively regulates stress-induced JNK activation and apoptosis by promoting MAP2K7 phosphorylation and inhibiting its ability to activate JNK. Following prolonged stress, anti-apoptotic effect stops because of degradation of RASSF7 protein via the ubiquitin-proteasome pathway. Required for the activation of AURKB and chromosomal congression during mitosis where it stimulates microtubule polymerization. {ECO:0000269|PubMed:20629633, ECO:0000269|PubMed:21278800}.
uniprot
proteins
mass_dalton
39945
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated and degraded by the proteasome upon prolonged stress stimuli.
uniprot
proteins
pubmed
1339391
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
20629633
uniprot
proteins
pubmed
21278800
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20629633}. Note=Colocalizes with gamma-tubulin.
uniprot
proteins