HAO1
entrez
54363
canonical
uniprot
Q9UJM8
canonical
ensembl
ENSG00000101323
resolver
ensp
ENSP00000368066
resolver
enst
ENST00000378789
resolver
genesymbol
HAO1
resolver
genesymbol_syn
GOX1
resolver
hgnc
HGNC:4809
resolver
uniprot
A8K058
resolver
uniprot
Q14CQ0
resolver
uniprot
Q9UPZ0
resolver
uniprot
Q9Y3I7
resolver
uniprot_entry
A8K058_HUMAN
resolver
uniprot_entry
HAOX1_HUMAN
resolver
uniprot_sec
Q14CQ0
resolver
uniprot_sec
Q9UPZ0
resolver
uniprot_sec
Q9Y3I7
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by its product oxalate (PubMed:17669354). Inhibited by high concentrations of dichlorophenolindophenol (DCIP) in vitro (PubMed:17669354). {ECO:0000269|PubMed:17669354}.
uniprot
proteins
amino_acid_sequence
MLPRLICINDYEQHAKSVLPKSIYDYYRSGANDEETLADNIAAFSRWKLYPRMLRNVAETDLSTSVLGQRVSMPICVGATAMQRMAHVDGELATVRACQSLGTGMMLSSWATSSIEEVAEAGPEALRWLQLYIYKDREVTKKLVRQAEKMGYKAIFVTVDTPYLGNRLDDVRNRFKLPPQLRMKNFETSTLSFSPEENFGDDSGLAAYVAKAIDPSISWEDIKWLRRLTSLPIVAKGILRGDDAREAVKHGLNGILVSNHGARQLDGVPATIDVLPEIVEAVEGKVEVFLDGGVRKGTDVLKALALGAKAVFVGRPIVWGLAFQGEKGVQDVLEILKEEFRLAMALSGCQNVKVIDKTLVRKNPLAVSKI
uniprot
proteins
ec_number
1.1.3.15
uniprot
proteins
ec_number
1.2.3.5
uniprot
proteins
function
FUNCTION: Broad substrate specificity (S)-2-hydroxy-acid oxidase that preferentially oxidizes glycolate (PubMed:10777549, PubMed:10978532, PubMed:17669354, PubMed:18215067). The glyoxylate produced by the oxidation of glycolate can then be utilized by alanine-glyoxylate aminotransferase for the peroxisomal synthesis of glycine; this pathway appears to be an important step for the detoxification of glyoxylate which, if allowed to accumulate, may be metabolized to oxalate with formation of kidney stones (PubMed:10978532, PubMed:17669354). Can also catalyze the oxidation of glyoxylate, and long chain hydroxyacids such as 2-hydroxyhexadecanoate and 2-hydroxyoctanoate, albeit with much lower catalytic efficiency (PubMed:10777549, PubMed:17669354, PubMed:18215067). Active in vitro with the artificial electron acceptor 2,6-dichlorophenolindophenol (DCIP), but O2 is believed to be the physiological electron acceptor, leading to the production of H2O2 (PubMed:10777549, PubMed:10978532, PubMed:17669354, PubMed:18215067). Is not active on L-lactate and 2-hydroxybutanoate (PubMed:10777549). {ECO:0000269|PubMed:10777549, ECO:0000269|PubMed:10978532, ECO:0000269|PubMed:17669354, ECO:0000269|PubMed:18215067, ECO:0000303|PubMed:10978532, ECO:0000303|PubMed:17669354}.
uniprot
proteins
mass_dalton
40924
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid biosynthesis; glycine biosynthesis. {ECO:0000303|PubMed:10978532}.
uniprot
proteins
protein_family
FMN-dependent alpha-hydroxy acid dehydrogenase family
uniprot
proteins
pubmed
10777549
uniprot
proteins
pubmed
10978532
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17669354
uniprot
proteins
pubmed
18215067
uniprot
proteins
pubmed
20054120
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
370
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome matrix {ECO:0000269|PubMed:10777549}.
uniprot
proteins