Meox1
entrez
17285
canonical
uniprot
P32442
canonical
ensembl
ENSMUSG00000001493
resolver
ensp
ENSMUSP00000051158
resolver
enst
ENSMUST00000057054
resolver
genesymbol
Meox1
resolver
genesymbol_syn
Mox-1
resolver
genesymbol_syn
Mox1
resolver
uniprot
Q543E8
resolver
uniprot_entry
MEOX1_MOUSE
resolver
uniprot_sec
Q543E8
resolver
amino_acid_sequence
MDPVANSCVRNPQPPAPVWGCLRNPHSEDSSASGLSHYPPTPFSFHQKSDFPATAAYPDFSASCLAATPHSLPRTERIFNEQHPAFPQTPDWHFPISEAGQRLNLGPAGSAREMGAGSPGLVDGTAGLGEDCMVLGTIANETEKKSSRRKKERSDNQENGGGKPEGSSKARKERTAFTKEQLRELEAEFAHHNYLTRLRRYEIAVNLDLSERQVKVWFQNRRMKWKRVKGGQPVSPQEQDREDGDSAASPSSE
uniprot
proteins
function
FUNCTION: Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:19520072). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome (PubMed:15024065). Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner (PubMed:22206000). Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome (By similarity). {ECO:0000250|UniProtKB:F1Q4R9, ECO:0000269|PubMed:12925591, ECO:0000269|PubMed:1363541, ECO:0000269|PubMed:15024065, ECO:0000269|PubMed:15039437, ECO:0000269|PubMed:18417617, ECO:0000269|PubMed:19520072, ECO:0000269|PubMed:22206000}.
uniprot
proteins
mass_dalton
27980
uniprot
proteins
mutagenesis
MUTAGEN 219; /note="Q->E: Abolishes DNA-binding. Does not affect ability to activate expression of CDKN2A."; /evidence="ECO:0000269|PubMed:22206000
uniprot
proteins
pubmed
12925591
uniprot
proteins
pubmed
1363541
uniprot
proteins
pubmed
15024065
uniprot
proteins
pubmed
15039437
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18417617
uniprot
proteins
pubmed
19520072
uniprot
proteins
pubmed
22206000
uniprot
proteins
sequence_length
253
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22206000}. Cytoplasm {ECO:0000269|PubMed:22206000}. Note=Localizes predominantly in the nucleus. {ECO:0000269|PubMed:22206000}.
uniprot
proteins