Med15
entrez
94112
canonical
uniprot
Q924H2
canonical
ensembl
ENSMUSG00000012114
resolver
ensp
ENSMUSP00000012259
resolver
ensp
ENSMUSP00000079737
resolver
ensp
ENSMUSP00000156242
resolver
ensp
ENSMUSP00000156291
resolver
ensp
ENSMUSP00000320634
resolver
ensp
ENSMUSP00000320635
resolver
ensp
ENSMUSP00000320636
resolver
ensp
ENSMUSP00000320637
resolver
ensp
ENSMUSP00000320639
resolver
enst
ENSMUST00000012259
resolver
enst
ENSMUST00000080936
resolver
enst
ENSMUST00000232236
resolver
enst
ENSMUST00000232645
resolver
genesymbol
Med15
resolver
genesymbol_syn
MED15
resolver
genesymbol_syn
Pcqap
resolver
genesymbol_syn
mFLJ00386
resolver
uniprot
A0A338P730
resolver
uniprot
A0A338P763
resolver
uniprot
E9Q7C1
resolver
uniprot
G3X8S4
resolver
uniprot
Q3TE00
resolver
uniprot
Q6KAM1
resolver
uniprot_entry
A0A338P730_MOUSE
resolver
uniprot_entry
A0A338P763_MOUSE
resolver
uniprot_entry
E9Q7C1_MOUSE
resolver
uniprot_entry
MED15_MOUSE
resolver
uniprot_entry
Q3TE00_MOUSE
resolver
uniprot_entry
Q6KAM1_MOUSE
resolver
uniprot_sec
G3X8S4
resolver
amino_acid_sequence
MDVSGQETDWRSAAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPTPGAAGIGMPPRGPGQSLGGMGGLGAMGQPLPLSGQPPPGTSGMAPHGMAVVSTATPQTQLQLQQVALQQQQQQQQQQQFQQQQAALQQQQQQQQQQQQQQQFQAQQNAMQQQFQAVVQQQQLQQQQQQQHLIKLHHQSQQQQIQQQQLQRMAQLQLQQQQQQQQQQALQAQPPMQQPSMQQPQPPPSQALPQQLSQLHHPQHHQPPPQAQQSPIAQNQPPQIPPQSQSQPLVSQAQALPGPMLYAAQQQLKFVRAPMVVQQPQVQPQVQQVQPQVQPQAAVQAAQSAQMVAPGVQMIAEALAQGGMHVRARFPPTSTMSAGPSSSISLGGQPTTQVSQSSLTMLSSPSPGQQVQTPQSMPPPPQPSPQPGSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVLPTKQQDLCQPLLDAVLANIRSPVFNHSLYRTFVPAMMAIHGPPIVSPVVCSRKRRFEEDERQSIPNVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPMWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSIHQACLSAA
uniprot
proteins
function
FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
86607
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by TRIM11, leading to proteasomal degradation. {ECO:0000250}.
uniprot
proteins
protein_family
Mediator complex subunit 15 family
uniprot
proteins
pubmed
11414760
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
789
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
uniprot
proteins