Gnat1
entrez
14685
canonical
uniprot
P20612
canonical
ensembl
ENSMUSG00000034837
resolver
ensp
ENSMUSP00000010205
resolver
enst
ENSMUST00000010205
resolver
genesymbol
Gnat1
resolver
genesymbol_syn
Gnat-1
resolver
uniprot
Q80X34
resolver
uniprot_entry
GNAT1_MOUSE
resolver
uniprot_sec
Q80X34
resolver
amino_acid_sequence
MGAGASAEEKHSRELEKKLKEDAEKDARTVKLLLLGAGESGKSTIVKQMKIIHQDGYSLEECLEFIAIIYGNTLQSILAIVRAMTTLNIQYGDSARQDDARKLMHMADTIEEGTMPKEMSDIIQRLWKDSGIQACFDRASEYQLNDSAGYYLSDLERLVTPGYVPTEQDVLRSRVKTTGIIETQFSFKDLNFRMFDVGGQRSERKKWIHCFEGVTCIIFIAALSAYDMVLVEDDEVNRMHESLHLFNSICNHRYFATTSIVLFLNKKDVFSEKIKKAHLSICFPDYDGPNTYEDAGNYIKVQFLELNMRRDVKEIYSHMTCATDTQNVKFVFDAVTDIIIKENLKDCGLF
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Alpha subunit of the heterotrimeric guanine nucleotide-binding protein (G protein) that transduces signals from the G protein-coupled photoreceptor rhodopsin (RHO). Essential for normal RHO-mediated light perception in retinal rod photoreceptors (By similarity). Functions as a GTPase, cycling between an active GTP-bound state and an inactive GDP-bound state. Under dim light conditions, photoactivated RHO promotes GDP release and GTP binding. In its active state, GNAT1 stimulates downstream effectors, including rod cGMP-phosphodiesterase (PDE6) complex, to mediate the phototransduction cascade (By similarity). Activation of the PDE6 complex occurs through binding and repositioning of the inhibitory PDE6 gamma subunits (PDE6G), thereby promoting catalytic activity (By similarity). {ECO:0000250|UniProtKB:P04695, ECO:0000250|UniProtKB:P11488}.
uniprot
proteins
mass_dalton
39967
uniprot
proteins
protein_family
G(i/o/t/z) subfamily
uniprot
proteins
protein_family
G-alpha family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2708360
uniprot
proteins
pubmed
31696965
uniprot
proteins
pubmed
8858601
uniprot
proteins
sequence_length
350
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Photoreceptor outer segment membrane {ECO:0000269|PubMed:31696965}; Peripheral membrane protein {ECO:0000250|UniProtKB:P04695}. Membrane {ECO:0000250|UniProtKB:P04695}; Peripheral membrane protein {ECO:0000250|UniProtKB:P04695}. Photoreceptor inner segment {ECO:0000269|PubMed:31696965}. Note=Localizes mainly in the outer segment in the dark-adapted state, whereas is translocated to the inner part of the photoreceptors in the light-adapted state. During dark-adapted conditions, in the presence of UNC119 mislocalizes from the outer segment to the inner part of rod photoreceptors which leads to decreased photoreceptor damage caused by light. {ECO:0000269|PubMed:31696965}.
uniprot
proteins