Ech1
entrez
64526
canonical
uniprot
Q62651
canonical
ensembl
ENSRNOG00000020308
resolver
ensembl
ENSRNOG00055033295
resolver
ensp
ENSRNOP00000085027
resolver
ensp
ENSRNOP00055047435
resolver
enst
ENSRNOT00055057543
resolver
genesymbol
Ech1
resolver
uniprot_entry
ECH1_RAT
resolver
amino_acid_sequence
MATAMTVSSKLLGLLMQQLRGTRQLYFNVSLRSLSSSAQEASKRIPEEVSDHNYESIQVTSAQKHVLHVQLNRPEKRNAMNRAFWRELVECFQKISKDSDCRAVVVSGAGKMFTSGIDLMDMASDILQPPGDDVARIAWYLRDLISRYQKTFTVIEKCPKPVIAAIHGGCIGGGVDLISACDIRYCTQDAFFQVKEVDVGLAADVGTLQRLPKVIGNRSLVNELTFTARKMMADEALDSGLVSRVFPDKDVMLNAAFALAADISSKSPVAVQGSKINLIYSRDHSVDESLDYMATWNMSMLQTQDIIKSVQAAMEKKDSKSITFSKL
uniprot
proteins
ec_number
5.3.3.21
uniprot
proteins
function
FUNCTION: Auxiliary enzyme in the beta-oxidation of mono- and polyunsaturated fatty acids. Together with the 2,4-dienoyl-CoA reductase (DECR) and the Enoyl-CoA delta isomerase 1 (ECI1) they allow reentrance of the enoyl-CoA into the beta-oxidation cycle (PubMed:11278886, PubMed:9417087). Able to isomerize 3-trans,5-cis-dienoyl-CoA (3E,5Z-dienoyl-CoA) to 2-trans,4-trans-dienoyl-CoA (2E,4E-dienoyl-CoA), a crucial step in the beta-oxidation of unsaturated fatty acids with double bonds at odd position (PubMed:11278886, PubMed:9417087). Based on its established catalytic mechanism, it is predicted to act also on other fatty acids besides those tested experimentally (By similarity). {ECO:0000250|UniProtKB:Q13011, ECO:0000269|PubMed:11278886, ECO:0000269|PubMed:9417087}.
uniprot
proteins
mass_dalton
36172
uniprot
proteins
mutagenesis
MUTAGEN 176; /note="D->A,D: Strongly decreases dienoyl-CoA and trienoyl-CoA isomerase activity."; /evidence="ECO:0000269|PubMed:11278886"; MUTAGEN 196; /note="E->D,Q: Strongly decreases dienoyl-CoA and trienoyl-CoA isomerase activity."; /evidence="ECO:0000269|PubMed:11278886"; MUTAGEN 204; /note="D->A,N: Strongly decreases dienoyl-CoA and trienoyl-CoA isomerase activity."; /evidence="ECO:0000269|PubMed:11278886
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid beta-oxidation. {ECO:0000269|PubMed:11278886, ECO:0000269|PubMed:9417087}.
uniprot
proteins
protein_family
Enoyl-CoA hydratase/isomerase family
uniprot
proteins
pubmed
11278886
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7558027
uniprot
proteins
pubmed
9417087
uniprot
proteins
pubmed
9739087
uniprot
proteins
sequence_length
327
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:11278886, ECO:0000269|PubMed:9417087}. Peroxisome {ECO:0000269|PubMed:11278886, ECO:0000269|PubMed:9417087}.
uniprot
proteins