TAC1
entrez
6863
canonical
uniprot
P20366
canonical
ensembl
ENSG00000006128
resolver
ensp
ENSP00000289574
resolver
ensp
ENSP00000289576
resolver
ensp
ENSP00000321106
resolver
ensp
ENSP00000534114
resolver
genesymbol
TAC1
resolver
genesymbol_syn
NKA
resolver
genesymbol_syn
NKNA
resolver
genesymbol_syn
TAC2
resolver
hgnc
HGNC:11517
resolver
uniprot
O60600
resolver
uniprot
O60601
resolver
uniprot
Q00072
resolver
uniprot
Q53GH4
resolver
uniprot
Q549V0
resolver
uniprot
Q549V1
resolver
uniprot
Q549V2
resolver
uniprot
Q6FHM1
resolver
uniprot
Q9Y494
resolver
uniprot_entry
Q9Y494_HUMAN
resolver
uniprot_entry
TKN1_HUMAN
resolver
uniprot_sec
O60600
resolver
uniprot_sec
O60601
resolver
uniprot_sec
Q00072
resolver
uniprot_sec
Q53GH4
resolver
uniprot_sec
Q549V0
resolver
uniprot_sec
Q549V1
resolver
uniprot_sec
Q549V2
resolver
uniprot_sec
Q6FHM1
resolver
amino_acid_sequence
MKILVALAVFFLVSTQLFAEEIGANDDLNYWSDWYDSDQIKEELPEPFEHLLQRIARRPKPQQFFGLMGKRDADSSIEKQVALLKALYGHGQISHKRHKTDSFVGLMGKRALNSVAYERSAMQNYERRR
uniprot
proteins
function
FUNCTION: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.; FUNCTION: [Substance P]: Is a ligand for TACR1, and triggers G protein-coupled receptor signaling via activation of phosphatidylinositol hydrolysis by phospholipase C. Substance P binding to TACR1 also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP) (By similarity). Is also a TACR3 agonist with low receptor affinity (PubMed:37391393). Basic secretagogue neuropeptide released from the terminals of specific sensory nerves (PubMed:30686732). Acts as a ligand for MRGPRX2 receptor in mast cells, initiating a signaling that mediates neurogenic inflammation and pain (PubMed:30686732, PubMed:34789875). Neurogenic inflammation includes mast cell activation, recruitment of immune cells and release of inflammatory mediators, such as cytokines and chemokines (By similarity). The inflammatory response can then activate or sensitize nociceptors, promoting pain (By similarity). {ECO:0000250|UniProtKB:P06767, ECO:0000250|UniProtKB:P41539, ECO:0000269|PubMed:30686732, ECO:0000269|PubMed:34789875, ECO:0000269|PubMed:37391393}.; FUNCTION: [Neurokinin A]: Is a ligand for TACR2, and triggers G protein-coupled receptor signaling via activation of G(q) and phosphatidylinositol hydrolysis by phospholipase C (PubMed:35882833). Binding to TACR2 also triggers signaling via activation of adenylate cyclase activity which results in increased intracellular levels of cyclic AMP (cAMP). {ECO:0000250|UniProtKB:P06767, ECO:0000269|PubMed:35882833}.
uniprot
proteins
mass_dalton
15003
uniprot
proteins
post_translational_modification
PTM: [Substance P]: The substance P form is cleaved at Pro-59 by the prolyl endopeptidase FAP (seprase) activity (in vitro) (PubMed:21314817). Substance P is also cleaved and degraded by Angiotensin-converting enzyme (ACE) and neprilysin (MME) (PubMed:6208535). {ECO:0000269|PubMed:21314817, ECO:0000269|PubMed:6208535}.
uniprot
proteins
protein_family
Tachykinin family
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16503654
uniprot
proteins
pubmed
1708336
uniprot
proteins
pubmed
21314817
uniprot
proteins
pubmed
2284201
uniprot
proteins
pubmed
3038549
uniprot
proteins
pubmed
30686732
uniprot
proteins
pubmed
34789875
uniprot
proteins
pubmed
35882833
uniprot
proteins
pubmed
37391393
uniprot
proteins
pubmed
3770210
uniprot
proteins
pubmed
6208535
uniprot
proteins
pubmed
9846828
uniprot
proteins
sequence_length
129
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.; SUBCELLULAR LOCATION: [Substance P]: Secreted {ECO:0000269|PubMed:21314817, ECO:0000269|PubMed:34789875}.
uniprot
proteins