FIS1
entrez
51024
canonical
uniprot
Q9Y3D6
canonical
ensembl
ENSG00000214253
resolver
ensp
ENSP00000223136
resolver
enst
ENST00000223136
resolver
genesymbol
FIS1
resolver
genesymbol_syn
TTC11
resolver
hgnc
HGNC:21689
resolver
uniprot
Q9BTP3
resolver
uniprot_entry
FIS1_HUMAN
resolver
uniprot_sec
Q9BTP3
resolver
amino_acid_sequence
MEAVLNELVSVEDLLKFEKKFQSEKAAGSVSKSTQFEYAWCLVRSKYNDDIRKGIVLLEELLPKGSKEEQRDYVFYLAVGNYRLKEYEKALKYVRGLLQTEPQNNQAKELERLIDKAMKKDGLVGMAIVGGMALGVAGLAGLIGLAVSKSKS
uniprot
proteins
function
FUNCTION: Involved in the fragmentation of the mitochondrial network and its perinuclear clustering (PubMed:12783892, PubMed:12861026, PubMed:14996942, PubMed:23283981). Plays a minor role in the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface and mitochondrial fission (PubMed:12861026, PubMed:16118244, PubMed:23283981, PubMed:23530241, PubMed:24196833). May not be essential for the assembly of functional fission complexes and the subsequent membrane scission event (PubMed:23530241, PubMed:24196833). Also mediates peroxisomal fission (PubMed:16107562). May act when the products of fission are directed toward mitochondrial homeostasis, mitophagy, or apoptosis (PubMed:24196833). Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis (PubMed:12783892). {ECO:0000269|PubMed:12783892, ECO:0000269|PubMed:12861026, ECO:0000269|PubMed:14996942, ECO:0000269|PubMed:16107562, ECO:0000269|PubMed:16118244, ECO:0000269|PubMed:23283981, ECO:0000269|PubMed:23530241, ECO:0000269|PubMed:24196833}.
uniprot
proteins
mass_dalton
16938
uniprot
proteins
mutagenesis
MUTAGEN 14; /note="L->P: Approximately 40% of cells display fragmented mitochondria."; /evidence="ECO:0000269|PubMed:16118244"; MUTAGEN 42; /note="L->P: Less than 15% of cells display fragmented mitochondria."; /evidence="ECO:0000269|PubMed:16118244"; MUTAGEN 58; /note="L->P: Less than 15% of cells display fragmented mitochondria."; /evidence="ECO:0000269|PubMed:16118244"; MUTAGEN 77; /note="L->P: Less than 15% of cells display fragmented mitochondria. Shows greatly reduced binding to DNM1L."; /evidence="ECO:0000269|PubMed:16118244"; MUTAGEN 91; /note="L->P: Less than 15% of cells display fragmented mitochondria. Shows greatly reduced binding to DNM1L."; /evidence="ECO:0000269|PubMed:16118244"; MUTAGEN 110; /note="L->P: Approximately 40% of cells display fragmented mitochondria. No change in binding to DNM1L."; /evidence="ECO:0000269|PubMed:16118244"; MUTAGEN 149; /note="K->A: Protein localizes to both mitochondrion and endoplasmic reticulum. Protein localizes to endoplasmic reticulum only; when associated with A-151."; /evidence="ECO:0000269|PubMed:14996942"; MUTAGEN 151; /note="K->A: Protein localizes to both mitochondrion and endoplasmic reticulum. Protein localizes to endoplasmic reticulum only; when associated with A-149."; /evidence="ECO:0000269|PubMed:14996942
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by MARCHF5. {ECO:0000269|PubMed:16874301}.
uniprot
proteins
protein_family
FIS1 family
uniprot
proteins
pubmed
10810093
uniprot
proteins
pubmed
12783892
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
12861026
uniprot
proteins
pubmed
14623186
uniprot
proteins
pubmed
14705031
uniprot
proteins
pubmed
14996942
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16107562
uniprot
proteins
pubmed
16118244
uniprot
proteins
pubmed
16874301
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20826455
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21701560
uniprot
proteins
pubmed
23283981
uniprot
proteins
pubmed
23530241
uniprot
proteins
pubmed
23921378
uniprot
proteins
pubmed
24196833
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
152
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:12783892, ECO:0000269|PubMed:14623186, ECO:0000269|PubMed:14996942, ECO:0000269|PubMed:16107562}; Single-pass membrane protein {ECO:0000269|PubMed:14996942}. Peroxisome membrane {ECO:0000269|PubMed:16107562}; Single-pass membrane protein {ECO:0000305|PubMed:16107562}.
uniprot
proteins
transmembrane_region
TRANSMEM 123..143; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins