Ash2l
entrez
23808
canonical
uniprot
Q91X20
canonical
ensembl
ENSMUSG00000031575
resolver
ensp
ENSMUSP00000070957
resolver
ensp
ENSMUSP00000106239
resolver
ensp
ENSMUSP00000106240
resolver
ensp
ENSMUSP00000132546
resolver
ensp
ENSMUSP00000287439
resolver
ensp
ENSMUSP00000348099
resolver
enst
ENSMUST00000068892
resolver
enst
ENSMUST00000110609
resolver
enst
ENSMUST00000110610
resolver
enst
ENSMUST00000166078
resolver
genesymbol
Ash2l
resolver
uniprot
E9PU93
resolver
uniprot
Q3UIF9
resolver
uniprot
Q3UJ62
resolver
uniprot
Q3UKZ9
resolver
uniprot
Q9Z2X4
resolver
uniprot_entry
ASH2L_MOUSE
resolver
uniprot_entry
E9PU93_MOUSE
resolver
uniprot_entry
Q3UJ62_MOUSE
resolver
uniprot_entry
Q3UKZ9_MOUSE
resolver
uniprot_sec
Q3UIF9
resolver
uniprot_sec
Q9Z2X4
resolver
amino_acid_sequence
MAAAGAGPGPGVSAGPGPGAAASATTAEDRETEPVAAGAGEGPSAAPGAEPSSGEAESGDANLVDVSGLETESSNGKDTLEGTGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMSKERDVFLVKEHPDPGSKDPEEDYPKFGLLDQDLSNIGPAYDNQKQSSAVSASGNLNGGIAAGSSGKGRGAKRKQQDGGTTGTTKKARSDPLFSAQRLPPHGYPLEHPFNKDGYRYILAEPDPHAPDPEKLELDCWAGKPIPGDLYRACLYERVLLALHDRAPQLKISDDRLTVVGEKGYSMVRASHGVRKGAWYFEITVDEMPPDTAARLGWSQPLGNLQAPLGYDKFSYSWRSKKGTKFHQSIGKHYSSGYGQGDVLGFYINLPEDTETAKSLPDTYKDKALIKFKSYLYFEEKDFVDKAEKSLKQTPHSEIIFYKNGVNQGVAYRDIFEGVYFPAISLYKSCTVSINFGPSFKYPPKDLTYHPMSDMGWGAVVEHTLADVLYHVETEVDGRRSPPWEP
uniprot
proteins
function
FUNCTION: Transcriptional regulator (By similarity). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (By similarity). Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated (By similarity). As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3 (By similarity). May play a role in hematopoiesis (By similarity). In association with RBBP5 and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (By similarity). {ECO:0000250|UniProtKB:Q9UBL3}.
uniprot
proteins
mass_dalton
68250
uniprot
proteins
post_translational_modification
PTM: Both monomethylated and dimethylated on arginine residues in the C-terminus. Arg-291 is the major site. Methylation is not required for nuclear localization, nor for MLL complex integrity or maintenance of global histone H3K4me3 levels (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
10393421
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21335234
uniprot
proteins
sequence_length
623
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins