Slc2a8
entrez
56017
canonical
uniprot
Q9JIF3
canonical
ensembl
ENSMUSG00000026791
resolver
ensp
ENSMUSP00000028129
resolver
ensp
ENSMUSP00000141959
resolver
ensp
ENSMUSP00000175046
resolver
ensp
ENSMUSP00000175049
resolver
ensp
ENSMUSP00000331411
resolver
enst
ENSMUST00000028129
resolver
enst
ENSMUST00000153484
resolver
genesymbol
Slc2a8
resolver
genesymbol_syn
Glut8
resolver
genesymbol_syn
GlutX1
resolver
uniprot
A0A0A6YXE8
resolver
uniprot
Q2TK26
resolver
uniprot
Q5BKP8
resolver
uniprot
Q9JJP4
resolver
uniprot
Q9JJZ0
resolver
uniprot_entry
A0A0A6YXE8_MOUSE
resolver
uniprot_entry
Q2TK26_MOUSE
resolver
uniprot_entry
SL2A8_MOUSE
resolver
uniprot_sec
Q5BKP8
resolver
uniprot_sec
Q9JJP4
resolver
uniprot_sec
Q9JJZ0
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by cytochalasin B. {ECO:0000269|PubMed:10821868}.
uniprot
proteins
amino_acid_sequence
MSPEDPQETQPLLRPPEARTPRGRRVFLASFAAALGPLSFGFALGYSSPAIPSLRRTAPPALRLGDNAASWFGAVVTLGAAAGGILGGWLLDRAGRKLSLLLCTVPFVTGFAVITAARDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVTGILLAYVAGWVLEWRWLAVLGCVPPTLMLLLMCYMPETPRFLLTQHQYQEAMAALRFLWGSEEGWEEPPVGAEHQGFQLALLRRPGIYKPLIIGISLMVFQQLSGVNAIMFYANSIFEEAKFKDSSLASVTVGIIQVLFTAVAALIMDRAGRRLLLALSGVIMVFSMSAFGTYFKLTQSLPSNSSHVGLVPIAAEPVDVQVGLAWLAVGSMCLFIAGFAVGWGPIPWLLMSEIFPLHVKGVATGICVLTNWFMAFLVTKEFSSVMEMLRPYGAFWLTAAFCALSVLFTLTVVPETKGRTLEQVTAHFEGR
uniprot
proteins
function
FUNCTION: Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose (PubMed:10821868, PubMed:10860996, PubMed:23396969). Facilitates hepatic influx of dietary trehalose, which in turn inhibits glucose and fructose influx triggering a starvation signal and hepatic autophagy through activation of AMPK and ULK1 (PubMed:27922102). Also able to mediate the transport of dehydroascorbate (PubMed:23396969). {ECO:0000269|PubMed:10821868, ECO:0000269|PubMed:10860996, ECO:0000269|PubMed:23396969, ECO:0000269|PubMed:27922102}.
uniprot
proteins
mass_dalton
51508
uniprot
proteins
mutagenesis
MUTAGEN 12..13; /note="LL->AA: Abolishes interaction with AP2B1."; /evidence="ECO:0000269|PubMed:16723738
uniprot
proteins
protein_family
Glucose transporter subfamily
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Sugar transporter (TC 2.A.1.1) family
uniprot
proteins
pubmed
10671487
uniprot
proteins
pubmed
10821868
uniprot
proteins
pubmed
10860996
uniprot
proteins
pubmed
11689004
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16723738
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23396969
uniprot
proteins
pubmed
27922102
uniprot
proteins
sequence_length
477
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10860996}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9JJZ1}; Multi-pass membrane protein {ECO:0000255}. Note=Principally intracellular. May move between intracellular vesicles and the plasma membrane. The dileucine internalization motif is critical for intracellular sequestration. {ECO:0000250|UniProtKB:Q9JJZ1}.
uniprot
proteins
transmembrane_region
TRANSMEM 26..46; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 71..91; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 97..117; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 128..148; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 157..177; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 183..203; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 258..278; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 294..314; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 321..341; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 368..388; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 405..425; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 439..459; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins