Dhx15
entrez
13204
canonical
uniprot
O35286
canonical
ensembl
ENSMUSG00000029169
resolver
ensp
ENSMUSP00000031061
resolver
ensp
ENSMUSP00000143069
resolver
enst
ENSMUST00000031061
resolver
enst
ENSMUST00000199321
resolver
genesymbol
Dhx15
resolver
genesymbol_syn
Ddx15
resolver
genesymbol_syn
Deah9
resolver
uniprot
A0A0G2JF88
resolver
uniprot
Q3UDX4
resolver
uniprot
Q3UKJ6
resolver
uniprot
Q497W9
resolver
uniprot
Q99L91
resolver
uniprot_entry
A0A0G2JF88_MOUSE
resolver
uniprot_entry
DHX15_MOUSE
resolver
uniprot_entry
Q3UDX4_MOUSE
resolver
uniprot_entry
Q3UKJ6_MOUSE
resolver
uniprot_entry
Q497W9_MOUSE
resolver
uniprot_sec
Q99L91
resolver
activity_regulation
ACTIVITY REGULATION: ATPase activity is enhanced upon binding to G-patch domain-containing proteins. G-patch domain-containing proteins act like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity, thereby promoting the ATPase activity. {ECO:0000250|UniProtKB:O43143}.
uniprot
proteins
amino_acid_sequence
MSKRHRLDLGEDYPSGKKRAGTDGKDRERDRDREDRSKDRDRERDRGDREREREKEKEKELRASTNAMLISAGLPPLKASHSAHSTHSAHSTHSTHSAHSTHTGHTGHTSLPQCINPFTNLPHTPRYYDILKKRLQLPVWEYKDRFTDILVRHQSFVLVGETGSGKTTQIPQWCVEYMRSLPGPKRGVACTQPRRVAAMSVAQRVADEMDVMLGQEVGYSIRFEDCSSAKTILKYMTDGMLLREAMNDPLLERYGVIILDEAHERTLATDILMGVLKEVVRQRSDLKVIVMSATLDAGKFQIYFDNCPLLTIPGRTHPVEIFYTPEPERDYLEAAIRTVIQIHMCEEEEGDLLLFLTGQEEIDEACKRIKREVDDLGPEVGDIKIIPLYSTLPPQQQQRIFEPPPPKKQNGAIGRKVVVSTNIAETSLTIDGVVFVIDPGFAKQKVYNPRIRVESLLVTAISKASAQQRAGRAGRTRPGKCFRLYTEKAYKTEMQDNTYPEILRSNLGSVVLQLKKLGIDDLVHFDFMDPPAPETLMRALELLNYLAALNDDGDLTELGSMMAEFPLDPQLAKMVIASCDYNCSNEVLSITAMLSVPQCFVRPTEAKKAADEAKMRFAHIDGDHLTLLNVYHAFKQNHESVQWCYDNFINYRSLMSADNVRQQLSRIMDRFNLPRRSTDFTSRDYYINIRKALVTGYFMQVAHLERTGHYLTVKDNQVVQLHPSTVLDHKPEWVLYNEFVLTTKNYIRTCTDIKPEWLVKIAPQYYDMSNFPQCEAKRQLDRIIAKLQSKEYSQY
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: RNA helicase involved in mRNA processing and antiviral innate immunity (PubMed:26494172, PubMed:34161762). Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA (By similarity). In cooperation with TFIP11 seem to be involved in the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns (By similarity). Plays a key role in antiviral innate immunity by promoting both MAVS-dependent signaling and NLRP6 inflammasome (PubMed:26494172). Acts as an RNA virus sensor: recognizes and binds viral double stranded RNA (dsRNA) and activates the MAVS-dependent signaling to produce interferon-beta and interferon lambda-3 (IFNL3) (By similarity). Involved in intestinal antiviral innate immunity together with NLRP6: recognizes and binds viral dsRNA and promotes activation of the NLRP6 inflammasome in intestinal epithelial cells to restrict infection by enteric viruses (PubMed:26494172, PubMed:34161762, PubMed:34678144). The NLRP6 inflammasome acts by promoting maturation and secretion of IL18 in the extracellular milieu (PubMed:34161762). Also involved in antibacterial innate immunity by promoting Wnt-induced antimicrobial protein expression in Paneth cells (PubMed:33483420). {ECO:0000250|UniProtKB:O43143, ECO:0000269|PubMed:26494172, ECO:0000269|PubMed:33483420, ECO:0000269|PubMed:34161762, ECO:0000269|PubMed:34678144}.
uniprot
proteins
mass_dalton
91007
uniprot
proteins
protein_family
DDX15/PRP43 sub-subfamily
uniprot
proteins
protein_family
DEAD box helicase family
uniprot
proteins
protein_family
DEAH subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26494172
uniprot
proteins
pubmed
33483420
uniprot
proteins
pubmed
34161762
uniprot
proteins
pubmed
34678144
uniprot
proteins
pubmed
9342318
uniprot
proteins
sequence_length
795
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9342318}. Nucleus, nucleolus {ECO:0000269|PubMed:9342318}.
uniprot
proteins