Gdnf
entrez
25453
canonical
uniprot
Q07731
canonical
ensembl
ENSRNOG00000083179
resolver
ensp
ENSRNOP00000107775
resolver
enst
ENSRNOT00000143194
resolver
genesymbol
Gdnf
resolver
uniprot
A0ABK0LYZ4
resolver
uniprot
A7UGJ1
resolver
uniprot
Q63214
resolver
uniprot
Q64062
resolver
uniprot
Q64063
resolver
uniprot
Q8R485
resolver
uniprot
Q9QX94
resolver
uniprot
Q9QX95
resolver
uniprot
Q9QXJ7
resolver
uniprot
Q9QXJ8
resolver
uniprot
Q9QXJ9
resolver
uniprot_entry
A0ABK0LYZ4_RAT
resolver
uniprot_entry
A7UGJ1_RAT
resolver
uniprot_entry
GDNF_RAT
resolver
uniprot_sec
Q63214
resolver
uniprot_sec
Q64062
resolver
uniprot_sec
Q64063
resolver
uniprot_sec
Q8R485
resolver
uniprot_sec
Q9QX94
resolver
uniprot_sec
Q9QX95
resolver
uniprot_sec
Q9QXJ7
resolver
uniprot_sec
Q9QXJ8
resolver
uniprot_sec
Q9QXJ9
resolver
amino_acid_sequence
MKLWDVVAVCLVLLHTASAFPLPAGKRLLEAPAEDHSLGHRRVPFALTSDSNMPEDYPDQFDDVMDFIQATIKRLKRSPDKQAAALPRRERNRQAAAASPENSRGKGRRGQRGKNRGCVLTAIHLNVTDLGLGYETKEELIFRYCSGSCEAAETMYDKILKNLSRSRRLTSDKVGQACCRPVAFDDDLSFLDDSLVYHILRKHSAKRCGCI
uniprot
proteins
function
FUNCTION: Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake (PubMed:10828539). Acts by binding to its coreceptor, GFRA1, leading to autophosphorylation and activation of the RET receptor (By similarity). May also modulate local neuronal effects in distal regions of the motor neuron (PubMed:10828539). Involved in the development of the neural crest (By similarity). {ECO:0000250|UniProtKB:P39905, ECO:0000269|PubMed:10828539}.
uniprot
proteins
mass_dalton
23619
uniprot
proteins
protein_family
GDNF subfamily
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
10828539
uniprot
proteins
pubmed
11930164
uniprot
proteins
pubmed
21994944
uniprot
proteins
pubmed
7696586
uniprot
proteins
pubmed
7867768
uniprot
proteins
pubmed
7895811
uniprot
proteins
pubmed
8493557
uniprot
proteins
pubmed
9187648
uniprot
proteins
sequence_length
211
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P39905}.
uniprot
proteins