Tasor
entrez
218850
canonical
uniprot
Q69ZR9
canonical
ensembl
ENSMUSG00000040651
resolver
ensp
ENSMUSP00000022450
resolver
ensp
ENSMUSP00000281477
resolver
genesymbol
Tasor
resolver
genesymbol_syn
D14Abb1e
resolver
genesymbol_syn
Fam208a
resolver
genesymbol_syn
Kiaa1105
resolver
uniprot
E9PUH2
resolver
uniprot
Q9CUD3
resolver
uniprot_entry
TASOR_MOUSE
resolver
uniprot_sec
E9PUH2
resolver
uniprot_sec
Q9CUD3
resolver
amino_acid_sequence
MATAAETEAPSTDASWKSRGGGGGDDGMKPALPELESSLQNGGGDGGGGAGPEETAAAEAARSYGHEQPQQTSEAAAAALPKGAEEPERPFRRSFQIPRKSREKKALFQPLTPGSREFEDVLNILHSSYLEPSSVTYFNYRRACLIHNELLEKEFTEKRRELKFDGRLDKELSESYAFLMVDRYQVQSICEKGLQVGQSKITVLGSPSMGIYLCRYADLLQANPLEAGAVGDVVIFKIMKGKIKSIYDPLSVKSLESMLSKNALDPTPKHECHVSKNASRITSLLAYRAYELTQYYFYEYGFDEVRRRPRHVCPYAVVSFTYKDDVQTPKFLSPLRSNSFNADRNIDKFNYTLWKGQLLNKGKLLCYISLRSANRAFLPVKLPEKLDVETVMSIDCLKQKIPPSFFYKDTYVGPNEVLKNGMYCSLYEVVEKTRIGSNMECLLQKLEKEKLVLVKPLGDRGYLFLLSPFQMVSPYEHQTVKSRILHALFLFQEPRCLIITQKGIMNTTPLEKPENLADILKITQFLQFSLIQCRKEFKTINTINFHSVVEKYVSEFFKRGFGSGKREFFMFSYDSRLDDRKFLYSAPRNKSHIDDCLHTYIYQPEMYQLSIFKLKELFEENWRRQQFSPLSDYEGQEEELNGSKMKFGKRNNSRDETTEPEQQKSSHSLDYDKDRVKELINLIQCTKKNVGGDPDPEDTKSKNVLKRKLEDLPENMRKFAKTSNSTESCHLYEESPQSIGLLGQDPNLRVQQEDSGNTGDIHKLYNWLSEALANARHSDGFLTETVNKALGLSSSGAYEELKQKCDYELNSTLDKKESEQPACTKIENVHFKDAQSPLLEVDAASVKYPPLLSSSEVGINHKLHCKEDPNLINVNNFEGCSLCPTVSIEHGFLRQHSKSNDDEETEIHWKLIPITGGNAGSPEDQHGKHGEKQTPDTLKGTTEEDTVTAGQAMAVEEQCVPAAELPRVSEITENTVLGEFHLFSRKVEEILKEKNVSYVSAISTPIFSAQEKMNRLSEFIHSNTSKAGVEEFVDGLHEKLNTVVITASAKGVSLPPAVSANHSHAAAALASLGRRVVSISSSDFSAKELFEPLCSEHLKDNNSNEQYSSSVEVEMNRPHHCKELMLTSDHTVPGDTVLEPTEKEITKSPSDITISAQPALSNFISQLEPEVFNSLVKIMKDVQKNTVKFYIHEEEESVLCKEIKEYLTKLGNTECHPDQFLERRSNLDKLLIIIQNEDIAGFIHKVPGLVTLKKLPCVSFAGVDSLDDVKNHTYNELFVSGGFIVSDESILNLEVVTIESLKIFLTFLEELSTPEGKWQWKIHCKFQKKLKELGRMNTKALSLLTLLNVYQKKHLVEILSYHSCDSQTRNAPEMDCLIRLQAQNIQQRHIVFLTEKNIKMVSSYTDNGIVVATTEDFMQNFTSLVGYHNSVTEESLPPLLGANENLESQSALLENDEKDEEDMSLDSGDEISHIEVFSNVHSEILAGETKGSSGTDQKKNIQIELQSSLDVQNSLLEDKTYLIDCEASAPIDRVCSEGESSNSAEQDAYSDFQADQNQLQMSHQCSHFNVLTHQTFLGTPYALSSTRSQENENYFLSAYKNSGTEKSPLS
uniprot
proteins
function
FUNCTION: Core component of the HUSH complex, a multiprotein complex that specifically mediates epigenetic repression of mobile genetic elements, such as retroviruses and transposable elements (By similarity). The HUSH complex represses LINE-1 (L1) retrotransposons that are still capable of transposition (By similarity). Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (By similarity). The HUSH complex also represses exogenous retroviruses and synthetic transgenes (By similarity). Mediates silencing of unintegrated retroviral DNA following recruitment by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (By similarity). The HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2, a chromatin remodeler that compacts chromatin (By similarity). Within the HUSH complex, TASOR acts as the central scaffold which recruits MPHOSPH8 and PPHLN1 to mobile genetic elements and mediates association with SETDB1 and MORC2 (By similarity). The ability to silence mobile genetic elements plays a crucial role in early embryonic development: it is required to maintain epiblast cell fitness and cell division (PubMed:24781204, PubMed:28839193). {ECO:0000250|UniProtKB:Q9UK61, ECO:0000269|PubMed:24781204, ECO:0000269|PubMed:28839193}.
uniprot
proteins
mass_dalton
181396
uniprot
proteins
mutagenesis
MUTAGEN 130; /note="L->P: In MommeD6; severe developmental delay leading to lethality before gastrulation. Mutants exhibit impaired primitive streak elongation, delayed epithelial-to-mesenchymal transition during gastrulation and an increase in p53/TP53-driven apoptosis. Epiblasts show an increased expression of p53 pathway genes as well as several pluripotency-associated long non-coding RNAs."; /evidence="ECO:0000269|PubMed:24781204
uniprot
proteins
protein_family
TASOR family
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24781204
uniprot
proteins
pubmed
28839193
uniprot
proteins
pubmed
31112734
uniprot
proteins
pubmed
34272044
uniprot
proteins
sequence_length
1610
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24781204}. Chromosome {ECO:0000250|UniProtKB:Q9UK61}. Note=Localizes to chromatin. {ECO:0000250|UniProtKB:Q9UK61}.
uniprot
proteins