NAA60
entrez
79903
canonical
uniprot
Q9H7X0
canonical
ensembl
ENSG00000122390
resolver
ensp
ENSP00000354108
resolver
ensp
ENSP00000385903
resolver
ensp
ENSP00000393224
resolver
ensp
ENSP00000401237
resolver
ensp
ENSP00000405873
resolver
ensp
ENSP00000458667
resolver
ensp
ENSP00000460763
resolver
ensp
ENSP00000461703
resolver
ensp
ENSP00000461730
resolver
enst
ENST00000576916
resolver
genesymbol
NAA60
resolver
genesymbol_syn
HAT4
resolver
genesymbol_syn
NAT15
resolver
hgnc
HGNC:25875
resolver
uniprot
A0A384NYU5
resolver
uniprot
B3KRQ0
resolver
uniprot
B4DLZ0
resolver
uniprot
B4DPZ8
resolver
uniprot
B4DYC4
resolver
uniprot
D3DUC2
resolver
uniprot
E7EQ65
resolver
uniprot
I3L153
resolver
uniprot
Q6IA31
resolver
uniprot
Q6UX26
resolver
uniprot_entry
A0A384NYU5_HUMAN
resolver
uniprot_entry
I3L153_HUMAN
resolver
uniprot_entry
NAA60_HUMAN
resolver
uniprot_sec
B3KRQ0
resolver
uniprot_sec
B4DLZ0
resolver
uniprot_sec
B4DPZ8
resolver
uniprot_sec
B4DYC4
resolver
uniprot_sec
D3DUC2
resolver
uniprot_sec
E7EQ65
resolver
uniprot_sec
Q6IA31
resolver
uniprot_sec
Q6UX26
resolver
amino_acid_sequence
MTEVVPSSALSEVSLRLLCHDDIDTVKHLCGDWFPIEYPDSWYRDITSNKKFFSLAATYRGAIVGMIVAEIKNRTKIHKEDGDILASNFSVDTQVAYILSLGVVKEFRKHGIGSLLLESLKDHISTTAQDHCKAIYLHVLTTNNTAINFYENRDFKQHHYLPYYYSIRGVLKDGFTYVLYINGGHPPWTILDYIQHLGSALASLSPCSIPHRVYRQAHSLLCSFLPWSGISSKSGIEYSRTM
uniprot
proteins
disease_involvement
DISEASE: Basal ganglia calcification, idiopathic, 9, autosomal recessive (IBGC9) [MIM:620786]: A form of basal ganglia calcification, a genetically heterogeneous condition characterized by symmetric calcification in the basal ganglia and other brain regions. Affected individuals can either be asymptomatic or show a wide spectrum of neuropsychiatric symptoms, including parkinsonism, dystonia, tremor, ataxia, dementia, psychosis, seizures, and chronic headache. Serum levels of calcium, phosphate, alkaline phosphatase and parathyroid hormone are normal. The neuropathological hallmark of the disease is vascular and pericapillary calcification, mainly of calcium phosphate, in the affected brain areas. {ECO:0000269|PubMed:38480682}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.3.1.259
uniprot
proteins
ec_number
2.3.1.48
uniprot
proteins
function
FUNCTION: N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol (PubMed:25732826, PubMed:38480682). Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met (PubMed:21750686, PubMed:25732826, PubMed:27320834, PubMed:27550639). Required for normal chromosomal segregation during anaphase (PubMed:21750686). May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidence (PubMed:21981917). {ECO:0000269|PubMed:21750686, ECO:0000269|PubMed:25732826, ECO:0000269|PubMed:27320834, ECO:0000269|PubMed:27550639, ECO:0000269|PubMed:38480682, ECO:0000305|PubMed:21981917}.
uniprot
proteins
mass_dalton
27451
uniprot
proteins
mutagenesis
MUTAGEN 19; /note="C->S: Does not affect localization to the Golgi apparatus; when associated with S-30; S-132; S-207 and S-222."; /evidence="ECO:0000269|PubMed:25732826"; MUTAGEN 30; /note="C->S: Does not affect localization to the Golgi apparatus; when associated with S-19; S-132; S-207 and S-222."; /evidence="ECO:0000269|PubMed:25732826"; MUTAGEN 34; /note="F->A: Abolished acetyltransferase activity."; /evidence="ECO:0000269|PubMed:27550639"; MUTAGEN 35; /note="P->A: Reduced acetyltransferase activity."; /evidence="ECO:0000269|PubMed:27320834"; MUTAGEN 36; /note="I->A: Reduced acetyltransferase activity."; /evidence="ECO:0000269|PubMed:27320834"; MUTAGEN 37; /note="E->A,F: Only slightly affects acetyltransferase activity."; /evidence="ECO:0000269|PubMed:27550639"; MUTAGEN 38; /note="Y->A: Strongly reduced acetyltransferase activity."; /evidence="ECO:0000269|PubMed:27320834, ECO:0000269|PubMed:27550639"; MUTAGEN 79; /note="K->A: Slightly reduced acetyltransferase activity."; /evidence="ECO:0000269|PubMed:27550639"; MUTAGEN 79; /note="K->R,Q: Increased acetyltransferase activity."; /evidence="ECO:0000269|PubMed:27550639"; MUTAGEN 79; /note="K->R: Decreased acetyltransferase activity; when associated with R-105, R-109, R-121 and R-156."; /evidence="ECO:0000269|PubMed:21981917"; MUTAGEN 80; /note="E->A: Slightly increased acetyltransferase activity."; /evidence="ECO:0000269|PubMed:27550639"; MUTAGEN 81; /note="D->A: Slightly increased acetyltransferase activity."; /evidence="ECO:0000269|PubMed:27320834, ECO:0000269|PubMed:27550639"; MUTAGEN 83; /note="D->A: Slightly increased acetyltransferase activity."; /evidence="ECO:0000269|PubMed:27550639"; MUTAGEN 84; /note="I->A: Slightly altered acetyltransferase activity."; /evidence="ECO:0000269|PubMed:27320834"; MUTAGEN 97; /note="Y->A,F: Abolished acetyltransferase activity."; /evidence="ECO:0000269|PubMed:27320834, ECO:0000269|PubMed:27550639"; MUTAGEN 105; /note="K->R: Decreased acetyltransferase activity; when associated with R-79, R-109, R-121 and R-156."; /evidence="ECO:0000269|PubMed:21981917"; MUTAGEN 109; /note="K->R: Decreased acetyltransferase activity; when associated with R-79, R-105, R-121 and R-156."; /evidence="ECO:0000269|PubMed:21981917"; MUTAGEN 111; /note="G->A: Abolishes acetyltransferase activity."; /evidence="ECO:0000269|PubMed:21981917"; MUTAGEN 121; /note="K->R: Decreased acetyltransferase activity; when associated with R-79, R-105, R-109 and R-156."; /evidence="ECO:0000269|PubMed:21981917"; MUTAGEN 132; /note="C->S: Does not affect localization to the Golgi apparatus; when associated with S-19; S-30; S-207 and S-222."; /evidence="ECO:0000269|PubMed:25732826"; MUTAGEN 138; /note="H->A,F: Abolished acetyltransferase activity."; /evidence="ECO:0000269|PubMed:27320834, ECO:0000269|PubMed:27550639"; MUTAGEN 140; /note="L->A: Decreased acetyltransferase activity."; /evidence="ECO:0000269|PubMed:27320834"; MUTAGEN 143; /note="N->A: Strongly reduced acetyltransferase activity."; /evidence="ECO:0000269|PubMed:27550639"; MUTAGEN 156; /note="K->R: Decreased histone acetyltransferase activity; when associated with R-79, R-105, R-109 and R-121."; /evidence="ECO:0000269|PubMed:21981917"; MUTAGEN 164; /note="Y->A,F: Slightly altered acetyltransferase activity."; /evidence="ECO:0000269|PubMed:27320834"; MUTAGEN 165; /note="Y->A,F: Strongly reduced acetyltransferase activity."; /evidence="ECO:0000269|PubMed:27320834, ECO:0000269|PubMed:27550639"; MUTAGEN 167; /note="I->A: Reduced acetyltransferase activity."; /evidence="ECO:0000269|PubMed:27320834"; MUTAGEN 207; /note="C->S: Does not affect localization to the Golgi apparatus; when associated with S-19; S-30; S-132 and S-222."; /evidence="ECO:0000269|PubMed:25732826"; MUTAGEN 220..221; /note="LL->AA: Does not affect localization to the Golgi apparatus."; /evidence="ECO:0000269|PubMed:25732826"; MUTAGEN 222; /note="C->S: Does not affect localization to the Golgi apparatus; when associated with S-19; S-30; S-132 and S-207."; /evidence="ECO:0000269|PubMed:25732826
uniprot
proteins
post_translational_modification
PTM: Acetylated: autoacetylation is required for optimal acetyltransferase activity. {ECO:0000269|PubMed:21981917}.
uniprot
proteins
protein_family
Acetyltransferase family
uniprot
proteins
protein_family
NAA60 subfamily
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
21593219
uniprot
proteins
pubmed
21750686
uniprot
proteins
pubmed
21981917
uniprot
proteins
pubmed
25732826
uniprot
proteins
pubmed
27320834
uniprot
proteins
pubmed
27550639
uniprot
proteins
pubmed
38480682
uniprot
proteins
sequence_length
242
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:21981917, ECO:0000269|PubMed:25732826, ECO:0000269|PubMed:38480682}; Peripheral membrane protein {ECO:0000269|PubMed:25732826}; Cytoplasmic side {ECO:0000269|PubMed:25732826}. Note=Probably forms an intramembrane hairpin-like structure in the membrane. {ECO:0000305|PubMed:25732826}.
uniprot
proteins