RBBP5
entrez
5929
canonical
uniprot
Q15291
canonical
ensembl
ENSG00000117222
resolver
ensp
ENSP00000264515
resolver
ensp
ENSP00000356132
resolver
ensp
ENSP00000531237
resolver
ensp
ENSP00000531239
resolver
ensp
ENSP00000701172
resolver
genesymbol
RBBP5
resolver
genesymbol_syn
RBQ3
resolver
hgnc
HGNC:9888
resolver
uniprot
A8K272
resolver
uniprot
B4DLF8
resolver
uniprot
Q7Z6D8
resolver
uniprot
Q8NDZ7
resolver
uniprot_entry
B4DLF8_HUMAN
resolver
uniprot_entry
RBBP5_HUMAN
resolver
uniprot_sec
A8K272
resolver
uniprot_sec
Q7Z6D8
resolver
uniprot_sec
Q8NDZ7
resolver
amino_acid_sequence
MNLELLESFGQNYPEEADGTLDCISMALTCTFNRWGTLLAVGCNDGRIVIWDFLTRGIAKIISAHIHPVCSLCWSRDGHKLVSASTDNIVSQWDVLSGDCDQRFRFPSPILKVQYHPRDQNKVLVCPMKSAPVMLTLSDSKHVVLPVDDDSDLNVVASFDRRGEYIYTGNAKGKILVLKTDSQDLVASFRVTTGTSNTTAIKSIEFARKGSCFLINTADRIIRVYDGREILTCGRDGEPEPMQKLQDLVNRTPWKKCCFSGDGEYIVAGSARQHALYIWEKSIGNLVKILHGTRGELLLDVAWHPVRPIIASISSGVVSIWAQNQVENWSAFAPDFKELDENVEYEERESEFDIEDEDKSEPEQTGADAAEDEEVDVTSVDPIAAFCSSDEELEDSKALLYLPIAPEVEDPEENPYGPPPDAVQTSLMDEGASSEKKRQSSADGSQPPKKKPKTTNIELQGVPNDEVHPLLGVKGDGKSKKKQAGRPKGSKGKEKDSPFKPKLYKGDRGLPLEGSAKGKVQAELSQPLTAGGAISELL
uniprot
proteins
function
FUNCTION: In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). Does not affect ES cell self-renewal (By similarity). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3 (PubMed:19556245). Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:19556245). In association with ASH2L and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:21220120, PubMed:22266653). {ECO:0000250|UniProtKB:Q8BX09, ECO:0000269|PubMed:19131338, ECO:0000269|PubMed:19556245, ECO:0000269|PubMed:21220120, ECO:0000269|PubMed:22266653}.
uniprot
proteins
mass_dalton
59153
uniprot
proteins
mutagenesis
MUTAGEN 374; /note="E->A: Significant reduction in its ability to stimulate KMT2A methyltransferase activity in association with WDR5 and ASH2L."; /evidence="ECO:0000269|PubMed:21220120"; MUTAGEN 375; /note="V->E: Significant reduction in its ability to stimulate KMT2A methyltransferase activity in association with WDR5 and ASH2L."; /evidence="ECO:0000269|PubMed:21220120"; MUTAGEN 376; /note="D->A: Reduced ability to stimulate KMT2A methyltransferase activity in association with WDR5 and ASH2L."; /evidence="ECO:0000269|PubMed:21220120"; MUTAGEN 377; /note="V->E: Reduced ability to stimulate KMT2A methyltransferase activity in association with WDR5 and ASH2L."; /evidence="ECO:0000269|PubMed:21220120
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14992727
uniprot
proteins
pubmed
15199122
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15960975
uniprot
proteins
pubmed
16253997
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17355966
uniprot
proteins
pubmed
17500065
uniprot
proteins
pubmed
17998332
uniprot
proteins
pubmed
18838538
uniprot
proteins
pubmed
19131338
uniprot
proteins
pubmed
19556245
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21220120
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22266653
uniprot
proteins
pubmed
23178126
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
7558034
uniprot
proteins
sequence_length
538
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17355966}.
uniprot
proteins