MFSD2B
entrez
388931
canonical
uniprot
A6NFX1
canonical
ensembl
ENSG00000205639
resolver
ensp
ENSP00000342501
resolver
enst
ENST00000338315
resolver
genesymbol
MFSD2B
resolver
hgnc
HGNC:37207
resolver
uniprot
B5MC32
resolver
uniprot
J3KNU6
resolver
uniprot_entry
MFS2B_HUMAN
resolver
uniprot_sec
B5MC32
resolver
uniprot_sec
J3KNU6
resolver
amino_acid_sequence
MAAPPAPAAKGSPQPEPHAPEPGPGSAKRGREDSRAGRLSFCTKVCYGIGGVPNQIASSATAFYLQLFLLDIAQIPAAQVSLVLFGGKVSGAAADPVAGFFINRSQRTGSGRLMPWVLGCTPFIALAYFFLWFLPPFTSLRGLWYTTFYCLFQALATFFQVPYTALTMLLTPCPRERDSATAYRMTVEMAGTLMGATVHGLIVSGAHRPHRCEATATPGPVTVSPNAAHLYCIAAAVVVVTYPVCISLLCLGVKERPDPSAPASGPGLSFLAGLSLTTRHPPYLKLVISFLFISAAVQVEQSYLVLFCTHASQLHDHVQGLVLTVLVSAVLSTPLWEWVLQRFGKKTSAFGIFAMVPFAILLAAVPTAPVAYVVAFVSGVSIAVSLLLPWSMLPDVVDDFQLQHRHGPGLETIFYSSYVFFTKLSGACALGISTLSLEFSGYKAGVCKQAEEVVVTLKVLIGAVPTCMILAGLCILMVGSTPKTPSRDASSRLSLRRRTSYSLA
uniprot
proteins
function
FUNCTION: Lipid transporter that specifically mediates export of sphingosine-1-phosphate in red blood cells and platelets (PubMed:29045386). Sphingosine-1-phosphate is a signaling sphingolipid and its export from red blood cells into in the plasma is required for red blood cell morphology (By similarity). Sphingosine-1-phosphate export from platelets is required for platelet aggregation and thrombus formation (By similarity). Mediates the export of different sphingosine-1-phosphate (S1P) species, including S1P(d18:0) (sphinganine 1-phosphate), S1P (d18:1) (sphing-4-enine 1-phosphate) and S1P (d18:2) (sphinga-4E,14Z-dienine-1-phosphate) (Probable). Release of sphingosine-1-phosphate is facilitated by a proton gradient (By similarity). In contrast, cations, such as sodium, are not required to drive sphingosine-1-phosphate transport (Probable). In addition to export, also able to mediate S1P import (By similarity). Does not transport lysophosphatidylcholine (LPC) (Probable). {ECO:0000250|UniProtKB:Q3T9M1, ECO:0000269|PubMed:29045386, ECO:0000305|PubMed:29563527}.
uniprot
proteins
mass_dalton
53743
uniprot
proteins
mutagenesis
MUTAGEN 95; /note="D->A: Abolishes export of sphingosine-1-phosphate."; /evidence="ECO:0000269|PubMed:29045386"; MUTAGEN 157; /note="T->A: Abolishes export of sphingosine-1-phosphate."; /evidence="ECO:0000269|PubMed:29045386"; MUTAGEN 423; /note="K->A: Does not affect export of sphingosine-1-phosphate."; /evidence="ECO:0000269|PubMed:29045386
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18694395
uniprot
proteins
pubmed
29045386
uniprot
proteins
pubmed
29563527
uniprot
proteins
sequence_length
504
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29045386, ECO:0000269|PubMed:29563527}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to the cell membrane and intracellular membranes. {ECO:0000269|PubMed:29045386}.
uniprot
proteins
transmembrane_region
TRANSMEM 113..133; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 150..170; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 185..205; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 233..253; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 287..307; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 320..340; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 350..370; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 373..393; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 412..432; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 459..479; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins