ADGRB1
entrez
575
canonical
uniprot
O14514
canonical
ensembl
ENSG00000181790
resolver
ensp
ENSP00000427783
resolver
ensp
ENSP00000430945
resolver
ensp
ENSP00000494563
resolver
enst
ENST00000517894
resolver
enst
ENST00000643448
resolver
genesymbol
ADGRB1
resolver
genesymbol_syn
BAI1
resolver
hgnc
HGNC:943
resolver
uniprot
A0A2R8Y5M7
resolver
uniprot_entry
A0A2R8Y5M7_HUMAN
resolver
uniprot_entry
AGRB1_HUMAN
resolver
amino_acid_sequence
MRGQAAAPGPVWILAPLLLLLLLLGRRARAAAGADAGPGPEPCATLVQGKFFGYFSAAAVFPANASRCSWTLRNPDPRRYTLYMKVAKAPVPCSGPGRVRTYQFDSFLESTRTYLGVESFDEVLRLCDPSAPLAFLQASKQFLQMRRQQPPQHDGLRPRAGPPGPTDDFSVEYLVVGNRNPSRAACQMLCRWLDACLAGSRSSHPCGIMQTPCACLGGEAGGPAAGPLAPRGDVCLRDAVAGGPENCLTSLTQDRGGHGATGGWKLWSLWGECTRDCGGGLQTRTRTCLPAPGVEGGGCEGVLEEGRQCNREACGPAGRTSSRSQSLRSTDARRREELGDELQQFGFPAPQTGDPAAEEWSPWSVCSSTCGEGWQTRTRFCVSSSYSTQCSGPLREQRLCNNSAVCPVHGAWDEWSPWSLCSSTCGRGFRDRTRTCRPPQFGGNPCEGPEKQTKFCNIALCPGRAVDGNWNEWSSWSACSASCSQGRQQRTRECNGPSYGGAECQGHWVETRDCFLQQCPVDGKWQAWASWGSCSVTCGAGSQRRERVCSGPFFGGAACQGPQDEYRQCGTQRCPEPHEICDEDNFGAVIWKETPAGEVAAVRCPRNATGLILRRCELDEEGIAYWEPPTYIRCVSIDYRNIQMMTREHLAKAQRGLPGEGVSEVIQTLVEISQDGTSYSGDLLSTIDVLRNMTEIFRRAYYSPTPGDVQNFVQILSNLLAEENRDKWEEAQLAGPNAKELFRLVEDFVDVIGFRMKDLRDAYQVTDNLVLSIHKLPASGATDISFPMKGWRATGDWAKVPEDRVTVSKSVFSTGLTEADEASVFVVGTVLYRNLGSFLALQRNTTVLNSKVISVTVKPPPRSLRTPLEIEFAHMYNGTTNQTCILWDETDVPSSSAPPQLGPWSWRGCRTVPLDALRTRCLCDRLSTFAILAQLSADANMEKATLPSVTLIVGCGVSSLTLLMLVIIYVSVWRYIRSERSVILINFCLSIISSNALILIGQTQTRNKVVCTLVAAFLHFFFLSSFCWVLTEAWQSYMAVTGHLRNRLIRKRFLCLGWGLPALVVAISVGFTKAKGYSTMNYCWLSLEGGLLYAFVGPAAAVVLVNMVIGILVFNKLVSKDGITDKKLKERAGASLWSSCVVLPLLALTWMSAVLAVTDRRSALFQILFAVFDSLEGFVIVMVHCILRREVQDAVKCRVVDRQEEGNGDSGGSFQNGHAQLMTDFEKDVDLACRSVLNKDIAACRTATITGTLKRPSLPEEEKLKLAHAKGPPTNFNSLPANVSKLHLHGSPRYPGGPLPDFPNHSLTLKRDKAPKSSFVGDGDIFKKLDSELSRAQEKALDTSYVILPTATATLRPKPKEEPKYSIHIDQMPQTRLIHLSTAPEASLPARSPPSRQPPSGGPPEAPPAQPPPPPPPPPPPPQQPLPPPPNLEPAPPSLGDPGEPAAHPGPSTGPSTKNENVATLSVSSLERRKSRYAELDFEKIMHTRKRHQDMFQDLNRKLQHAAEKDKEVLGPDSKPEKQQTPNKRPWESLRKAHGTPTWVKKELEPLQPSPLELRSVEWERSGATIPLVGQDIIDLQTEV
uniprot
proteins
function
FUNCTION: Phosphatidylserine receptor which enhances the engulfment of apoptotic cells (PubMed:24509909). Also mediates the binding and engulfment of Gram-negative bacteria (PubMed:26838550). Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity (PubMed:26838550). In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells (PubMed:24509909). Promotes myoblast fusion (By similarity). Activates the Rho pathway in a G protein-dependent manner (PubMed:23782696). Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity (By similarity). Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1 (By similarity). Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma (PubMed:11875720). {ECO:0000250|UniProtKB:C0HL12, ECO:0000250|UniProtKB:Q3UHD1, ECO:0000269|PubMed:11875720, ECO:0000269|PubMed:23782696, ECO:0000269|PubMed:24509909, ECO:0000269|PubMed:26838550}.; FUNCTION: [Vasculostatin-120]: Inhibits angiogenesis in a CD36-dependent manner. {ECO:0000269|PubMed:15782143, ECO:0000269|PubMed:19176395}.; FUNCTION: [Vasculostatin-40]: Inhibits angiogenesis. {ECO:0000269|PubMed:22330140}.
uniprot
proteins
mass_dalton
173501
uniprot
proteins
mutagenesis
MUTAGEN 323..325; /note="RSQ->AAA: Abolishes processing of vasculostatin-40."; /evidence="ECO:0000269|PubMed:22330140"; MUTAGEN 326..328; /note="SLR->AAA: Does not affect processing of vasculostatin-40."; /evidence="ECO:0000269|PubMed:22330140"; MUTAGEN 927; /note="S->A: Abolishes cleavage and production of vasculostatin-120."; /evidence="ECO:0000269|PubMed:15782143"; MUTAGEN 927; /note="S->D: Increased levels of vasculostatin-120 and decreased levels of vasculostatin-40."; /evidence="ECO:0000269|PubMed:22330140
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved to produce vasculostatin-40 and vasculostatin-120 (PubMed:15782143, PubMed:22330140, PubMed:22333914). Vasculostatin-40 is the major form and is produced through proteolytic cleavage by MMP14 between residues 321 and 329 with cleavage likely to be between Ser-326 and Leu-327 (PubMed:22330140). {ECO:0000269|PubMed:15782143, ECO:0000269|PubMed:22330140, ECO:0000269|PubMed:22333914}.; PTM: Ubiquitinated. {ECO:0000269|PubMed:23782696}.
uniprot
proteins
protein_family
G protein-coupled receptor 2 family
uniprot
proteins
protein_family
LN-TM7 subfamily
uniprot
proteins
pubmed
10343108
uniprot
proteins
pubmed
10748157
uniprot
proteins
pubmed
11875720
uniprot
proteins
pubmed
12074842
uniprot
proteins
pubmed
12507886
uniprot
proteins
pubmed
15782143
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
19176395
uniprot
proteins
pubmed
22330140
uniprot
proteins
pubmed
22333914
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23595754
uniprot
proteins
pubmed
23782696
uniprot
proteins
pubmed
24509909
uniprot
proteins
pubmed
26710850
uniprot
proteins
pubmed
26838550
uniprot
proteins
pubmed
9393972
uniprot
proteins
pubmed
9647739
uniprot
proteins
pubmed
9790924
uniprot
proteins
sequence_length
1584
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12074842, ECO:0000269|PubMed:26838550}; Multi-pass membrane protein {ECO:0000255}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:Q3UHD1}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q3UHD1}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:C0HL12}. Postsynaptic density {ECO:0000250|UniProtKB:Q3UHD1}.; SUBCELLULAR LOCATION: [Vasculostatin-120]: Secreted {ECO:0000269|PubMed:15782143, ECO:0000269|PubMed:22330140}.; SUBCELLULAR LOCATION: [Vasculostatin-40]: Secreted {ECO:0000269|PubMed:22330140}.
uniprot
proteins
transmembrane_region
TRANSMEM 949..969; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 981..1001; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 1009..1029; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 1053..1073; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 1094..1114; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 1137..1157; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 1167..1187; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins