NLRP10
entrez
338322
canonical
uniprot
Q86W26
canonical
ensembl
ENSG00000182261
resolver
ensembl
ENSG00000276780
resolver
ensembl
ENSG00000281166
resolver
ensp
ENSP00000327763
resolver
ensp
ENSP00000478480
resolver
ensp
ENSP00000486762
resolver
ensp
ENSP00000509542
resolver
enst
ENST00000328600
resolver
enst
ENST00000612291
resolver
enst
ENST00000625327
resolver
enst
ENST00000691676
resolver
genesymbol
NLRP10
resolver
genesymbol_syn
NALP10
resolver
genesymbol_syn
NOD8
resolver
genesymbol_syn
PYNOD
resolver
hgnc
HGNC:21464
resolver
uniprot
Q2M3C4
resolver
uniprot
Q6JGT0
resolver
uniprot_entry
NAL10_HUMAN
resolver
uniprot_sec
Q2M3C4
resolver
uniprot_sec
Q6JGT0
resolver
amino_acid_sequence
MAMAKARKPREALLWALSDLEENDFKKLKFYLRDMTLSEGQPPLARGELEGLIPVDLAELLISKYGEKEAVKVVLKGLKVMNLLELVDQLSHICLHDYREVYREHVRCLEEWQEAGVNGRYNQVLLVAKPSSESPESLACPFPEQELESVTVEALFDSGEKPSLAPSLVVLQGSAGTGKTTLARKMVLDWATGTLYPGRFDYVFYVSCKEVVLLLESKLEQLLFWCCGDNQAPVTEILRQPERLLFILDGFDELQRPFEEKLKKRGLSPKESLLHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHVHILGFSEEERARYFSSYFTDEKQADRAFDIVQKNDILYKACQVPGICWVVCSWLQGQMERGKVVLETPRNSTDIFMAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAAEGIQHQRFLFEEAELRKHNLDGPRLAAFLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSYLVKEDQSRLGKESRREVQRLLEVKEQEGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPCLAQDLKHFKEQMESMKHNRTWDLEFSLYEAKIKNLVKGIQMNNVSFKIKHSNEKKSQSQNLFSVKSSLSHGPKEEQKCPSVHGQKEGKDNIAGTQKEASTGKGRGTEETPKNTYI
uniprot
proteins
function
FUNCTION: Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID (PubMed:15096476). Displays anti-inflammatory activity (PubMed:20393137). Required for immunity against C.albicans infection (By similarity). Involved in the innate immune response by contributing to pro-inflammatory cytokine release in response to invasive bacterial infection (PubMed:22672233). Contributes to T-cell-mediated inflammatory responses in the skin (By similarity). Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens (PubMed:28766990). Exhibits both ATPase and GTPase activities (PubMed:23861819). {ECO:0000250|UniProtKB:Q8CCN1, ECO:0000269|PubMed:15096476, ECO:0000269|PubMed:20393137, ECO:0000269|PubMed:22672233, ECO:0000269|PubMed:23861819}.
uniprot
proteins
mass_dalton
75032
uniprot
proteins
mutagenesis
MUTAGEN 179; /note="K->A: Reduced release of IL8 following invasive bacterial infection."; /evidence="ECO:0000269|PubMed:22672233"; MUTAGEN 252; /note="D->A: Reduced release of IL8 following invasive bacterial infection."; /evidence="ECO:0000269|PubMed:22672233
uniprot
proteins
protein_family
NLRP family
uniprot
proteins
pubmed
12563287
uniprot
proteins
pubmed
12766759
uniprot
proteins
pubmed
15096476
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20393137
uniprot
proteins
pubmed
22618865
uniprot
proteins
pubmed
22672233
uniprot
proteins
pubmed
23861819
uniprot
proteins
pubmed
28766990
uniprot
proteins
sequence_length
655
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22672233}. Cell membrane {ECO:0000269|PubMed:22672233}; Peripheral membrane protein {ECO:0000305}. Note=Cytoplasmic protein which is recruited to the cell membrane by NOD1 following invasive bacterial infection. {ECO:0000269|PubMed:22672233}.
uniprot
proteins