Glrb
entrez
25456
canonical
uniprot
P20781
canonical
ensembl
ENSRNOG00000010199
resolver
ensembl
ENSRNOG00055001476
resolver
ensembl
ENSRNOG00060007071
resolver
ensembl
ENSRNOG00065030413
resolver
ensp
ENSRNOP00000014170
resolver
ensp
ENSRNOP00055001820
resolver
ensp
ENSRNOP00060008735
resolver
ensp
ENSRNOP00065043099
resolver
enst
ENSRNOT00000014170
resolver
enst
ENSRNOT00055002394
resolver
enst
ENSRNOT00060011621
resolver
enst
ENSRNOT00065052425
resolver
genesymbol
Glrb
resolver
uniprot_entry
GLRB_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Channel opening is triggered by extracellular glycine (PubMed:14551753, PubMed:15574743). Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 (By similarity). {ECO:0000250|UniProtKB:P48167, ECO:0000269|PubMed:14551753, ECO:0000269|PubMed:15574743}.
uniprot
proteins
amino_acid_sequence
MKFSLAVSFFILMSLLFEDACSKEKSSKKGKGKKKQYLCPSQQSAEDLARVPPNSTSNILNRLLVSYDPRIRPNFKGIPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPTMYKCLWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRCKMQLESFGYTTDDLRFIWQSGDPVQLEKIALPQFDIKKEDIEYGNCTKYYKGTGYYTCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASECTTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQADGKGGNAAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELSNYDCYGKPIEVNNGLGKPQAKNKKPPPAKPVIPTAAKRIDLYARALFPFCFLFFNVIYWSIYL
uniprot
proteins
function
FUNCTION: Subunit of heteromeric glycine-gated chloride channels (PubMed:15574743). Plays an important role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents (By similarity). {ECO:0000250|UniProtKB:P48167, ECO:0000250|UniProtKB:P48168, ECO:0000269|PubMed:15574743}.
uniprot
proteins
mass_dalton
55927
uniprot
proteins
protein_family
GLRB sub-subfamily
uniprot
proteins
protein_family
Glycine receptor (TC 1.A.9.3) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
14551753
uniprot
proteins
pubmed
15201864
uniprot
proteins
pubmed
15574743
uniprot
proteins
pubmed
16511563
uniprot
proteins
pubmed
2163264
uniprot
proteins
pubmed
22592841
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8581315
uniprot
proteins
sequence_length
496
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000305|PubMed:22592841}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23415}. Cell membrane {ECO:0000269|PubMed:14551753, ECO:0000269|PubMed:15574743, ECO:0000269|PubMed:22592841, ECO:0000269|PubMed:8581315}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P23415}. Synapse {ECO:0000269|PubMed:22592841}. Perikaryon {ECO:0000269|PubMed:22592841}. Cell projection, dendrite {ECO:0000269|PubMed:22592841}. Cytoplasm {ECO:0000269|PubMed:8581315}. Note=Retained in the cytoplasm upon heterologous expression by itself. Coexpression with GPHN promotes expression at the cell membrane. Coexpression with GLRA1, GLRA2 or GLRA3 promotes expression at the cell membrane. {ECO:0000269|PubMed:8581315}.
uniprot
proteins
transmembrane_region
TRANSMEM 269..289; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P48167"; TRANSMEM 295..315; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P48167"; TRANSMEM 328..349; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P48167"; TRANSMEM 472..495; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P48167
uniprot
proteins