Fnbp1l
entrez
310839
canonical
uniprot
Q2HWF0
canonical
ensembl
ENSRNOG00000013798
resolver
ensp
ENSRNOP00000052531
resolver
ensp
ENSRNOP00000083605
resolver
ensp
ENSRNOP00000090789
resolver
ensp
ENSRNOP00000100138
resolver
enst
ENSRNOT00000055669
resolver
genesymbol
Fnbp1l
resolver
genesymbol_syn
Toca1
resolver
uniprot
A0A8L2QQ20
resolver
uniprot
Q2HWE9
resolver
uniprot_entry
A0A8L2QQ20_RAT
resolver
uniprot_entry
FBP1L_RAT
resolver
uniprot_sec
Q2HWE9
resolver
amino_acid_sequence
MSWGTELWDQFDSLDKHTQWGIDFLERYAKFVKERIEIEQNYAKQLRNLVKKYCPKRSSKDEEPRFTSCIAFFNILNELNDYAGQREVVAEEMAHRVYGELMRYAHDLKTERKMHLQEGRKAQQYLDMCWKQMDNSKKKFERECREAEKAQQSYERLDNDTNATKADVEKAKQQLNLRTHMADENKNEYAAQLQNFNGEQHKHFYVVIPQIYKQLQEMDERRTIKLSECYRGFADSERKVIPIISKCLEGMILAAKSVDERRDSQMVVDSFKSGFEPPGDFPFEDYSQHIYRTVSDGTISASKQEGGKMDSKSTAGKAKGKLWLFGKKPKPQSPPLTPTSLFTSSPPNGSQFLTLSIEPVHYCMNEIKTGKPRIPSFRSLKRGWSMKMGPALEDFSHLPPEQRRKKLQQRIDELNRGLQKESDQKEALNKMKDVYEKNPQMGDPGSLQPKLAETMNNIDRLRMEIHKNEAWLSEVEGKTGVRGDRRHSSDINHLVTQGRESPEGSYTDDANQEVRGPPQQHGHHSEFDDEFEDDDPLPAIGHCKAIYPFDGHNEGTLAMKEGEVLYIIEEDKGDGWTRARRQNGEEGYVPTTYIDVTLEKNSKGS
uniprot
proteins
function
FUNCTION: Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL-WASPIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens (By similarity). May negatively regulate neurite extension and axon branching in developing neurons. {ECO:0000250, ECO:0000269|PubMed:16885158}.
uniprot
proteins
mass_dalton
69974
uniprot
proteins
mutagenesis
MUTAGEN 51..52; /note="KK->QQ: Impairs membrane tubulation and suppression of neurite elongation."; /evidence="ECO:0000269|PubMed:16885158
uniprot
proteins
protein_family
FNBP1 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
16885158
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
605
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16885158}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Localized to the cell body, axons and neurites of differentiating neurons.
uniprot
proteins