Siah2
entrez
140593
canonical
uniprot
Q8R4T2
canonical
ensembl
ENSRNOG00000013703
resolver
ensembl
ENSRNOG00055018534
resolver
ensembl
ENSRNOG00060004879
resolver
ensembl
ENSRNOG00065024096
resolver
ensp
ENSRNOP00000018488
resolver
ensp
ENSRNOP00055025433
resolver
ensp
ENSRNOP00060006081
resolver
ensp
ENSRNOP00065033756
resolver
enst
ENSRNOT00000018488
resolver
enst
ENSRNOT00055031497
resolver
enst
ENSRNOT00060008113
resolver
enst
ENSRNOT00065041326
resolver
genesymbol
Siah2
resolver
uniprot
Q920M8
resolver
uniprot_entry
SIAH2_RAT
resolver
uniprot_sec
Q920M8
resolver
amino_acid_sequence
MSRPSSTGPSANKPCSKQPPPPQTPHAPSPAAPPAAATISAAGPGSSAVPAAAAVISGPGAGGGAGPVSPQHHELTSLFECPVCFDYVLPPILQCQAGHLVCNQCRQKLSCCPTCRGALTPSIRNLAMEKVASAVLFPCKYATTGCSLTLHHTEKPEHEDICEYRPYSCPCPGASCKWQGSLEAVMSHLMHAHKSITTLQGEDIVFLATDINLPGAVDWVMMQSCFGHHFMLVLEKQEKYEGHQQFFAIVLLIGTRKQAENFAYRLELNGNRRRLTWEATPRSIHDGVAAAIMNSDCLVFDTAIAHLFADNGNLGINVTISTCCQ
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:11786535). E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:11786535). Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes (By similarity). Mediates ubiquitination and proteasomal degradation of DYRK2 in response to hypoxia (By similarity). Promotes monoubiquitination of SNCA (By similarity). Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (GPS2, POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a protein involved in synaptic vesicle function in neurons (SYP) (PubMed:11786535). It is thereby involved in apoptosis, tumor suppression, cell cycle, transcription and signaling processes (By similarity). Has some overlapping function with SIAH1 (By similarity). Triggers the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 does not (By similarity). Regulates cellular clock function via ubiquitination of circadian transcriptional repressors NR1D1 and NR1D2 leading to their proteasomal degradation. Plays an important role in mediating the rhythmic degradation/clearance of NR1D1 and NR1D2 contributing to their circadian profile of protein abundance (By similarity). Mediates ubiquitination and degradation of EGLN2 and EGLN3 in response to the unfolded protein response (UPR), leading to their degradation and subsequent stabilization of ATF4 (By similarity). Also part of the Wnt signaling pathway in which it mediates the Wnt-induced ubiquitin-mediated proteasomal degradation of AXIN1 (By similarity). {ECO:0000250|UniProtKB:O43255, ECO:0000250|UniProtKB:Q06986, ECO:0000269|PubMed:11786535}.
uniprot
proteins
mass_dalton
34700
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:11786535}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Thr-24 and Ser-29 by MAPK14, which mediates the degradation by the proteasome of EGLN3. Phosphorylated at Ser-29 by DYRK2; this increases the ubiquitin ligase activity and promotes degradation of EGLN3 (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
SINA (Seven in absentia) family
uniprot
proteins
pubmed
11786535
uniprot
proteins
pubmed
15064394
uniprot
proteins
pubmed
19224863
uniprot
proteins
sequence_length
325
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19224863}. Nucleus {ECO:0000305|PubMed:19224863}. Note=Predominantly cytoplasmic. Partially nuclear. {ECO:0000250|UniProtKB:O43255}.
uniprot
proteins