Irak1bp1
entrez
65099
canonical
uniprot
Q9ESJ7
canonical
ensembl
ENSMUSG00000032251
resolver
ensp
ENSMUSP00000034783
resolver
ensp
ENSMUSP00000108871
resolver
enst
ENSMUST00000034783
resolver
enst
ENSMUST00000113245
resolver
genesymbol
Irak1bp1
resolver
genesymbol_syn
Aip70
resolver
genesymbol_syn
Simpl
resolver
uniprot
G5E885
resolver
uniprot
Q8BT82
resolver
uniprot
Q8C645
resolver
uniprot
Q9CRM0
resolver
uniprot
Q9CV21
resolver
uniprot
Q9CX27
resolver
uniprot
Q9JK12
resolver
uniprot_entry
G5E885_MOUSE
resolver
uniprot_entry
IKBP1_MOUSE
resolver
uniprot_sec
Q8BT82
resolver
uniprot_sec
Q8C645
resolver
uniprot_sec
Q9CRM0
resolver
uniprot_sec
Q9CV21
resolver
uniprot_sec
Q9CX27
resolver
uniprot_sec
Q9JK12
resolver
amino_acid_sequence
MSLQPAPASRVFMELVPWADRGRENHPISAAEAQPIGRRPHVAEAHPGAREVHVSGAAEVSASPDRALVTVRVSSTKEVSAEAKKSVCRRLDYITQSLQQQGFQAENVTVTKNIRRVENAYHMEAEVCITFTEFGKMQNICNFLVEKLDSSVVISPPEFYHTPGSVENLRRQACLVAVENAWRKAQEVCDLVGQTLGKPLLIKEEETKDWEGQTDDHQLSRLPGTLTVQQKIKSATIHAASKVFITFEVKGKEKKKKHL
uniprot
proteins
function
FUNCTION: Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity. {ECO:0000269|PubMed:11096118, ECO:0000269|PubMed:15485901}.
uniprot
proteins
mass_dalton
28861
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-55, Ser-61 and/or Ser-63 is required for full activity. Phosphorylated on at least one of Ser-234, Thr-236, Ser-241 and Thr-246 upon TNF activation, which favors nuclear translocation. {ECO:0000269|PubMed:17079333}.
uniprot
proteins
protein_family
IRAK1BP1 family
uniprot
proteins
pubmed
11096118
uniprot
proteins
pubmed
11207567
uniprot
proteins
pubmed
15485901
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17079333
uniprot
proteins
pubmed
17233114
uniprot
proteins
sequence_length
259
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15485901}. Nucleus {ECO:0000269|PubMed:15485901}.
uniprot
proteins