SLC30A4
entrez
7782
canonical
uniprot
O14863
canonical
ensembl
ENSG00000104154
resolver
ensp
ENSP00000261867
resolver
ensp
ENSP00000524712
resolver
enst
ENST00000261867
resolver
enst
ENST00000854653
resolver
genesymbol
SLC30A4
resolver
genesymbol_syn
ZNT4
resolver
hgnc
HGNC:11015
resolver
uniprot
Q8TC39
resolver
uniprot_entry
ZNT4_HUMAN
resolver
uniprot_sec
Q8TC39
resolver
amino_acid_sequence
MAGSGAWKRLKSMLRKDDAPLFLNDTSAFDFSDEAGDEGLSRFNKLRVVVADDGSEAPERPVNGAHPTLQADDDSLLDQDLPLTNSQLSLKVDSCDNCSKQREILKQRKVKARLTIAAVLYLLFMIGELVGGYIANSLAIMTDALHMLTDLSAIILTLLALWLSSKSPTKRFTFGFHRLEVLSAMISVLLVYILMGFLLYEAVQRTIHMNYEINGDIMLITAAVGVAVNVIMGFLLNQSGHRHSHSHSLPSNSPTRGSGCERNHGQDSLAVRAAFVHALGDLVQSVGVLIAAYIIRFKPEYKIADPICTYVFSLLVAFTTFRIIWDTVVIILEGVPSHLNVDYIKEALMKIEDVYSVEDLNIWSLTSGKSTAIVHIQLIPGSSSKWEEVQSKANHLLLNTFGMYRCTIQLQSYRQEVDRTCANCQSSSP
uniprot
proteins
function
FUNCTION: Probable proton-coupled zinc ion antiporter mediating zinc import from cytoplasm potentially into the endocytic compartment (PubMed:19521526). Controls zinc deposition in milk (By similarity). {ECO:0000250|UniProtKB:O35149, ECO:0000305|PubMed:19521526}.
uniprot
proteins
mass_dalton
47483
uniprot
proteins
mutagenesis
MUTAGEN 355; /note="Y->F: Decreased homodimerization."; /evidence="ECO:0000269|PubMed:19521526"; MUTAGEN 404; /note="Y->F: Decreased homodimerization."; /evidence="ECO:0000269|PubMed:19521526"; MUTAGEN 413; /note="Y->F: Decreased homodimerization."; /evidence="ECO:0000269|PubMed:19521526
uniprot
proteins
post_translational_modification
PTM: Homodimerization through dityrosine bonds is stimulated by oxidative stress. {ECO:0000269|PubMed:19521526}.
uniprot
proteins
protein_family
Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
uniprot
proteins
protein_family
SLC30A subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17349999
uniprot
proteins
pubmed
19521526
uniprot
proteins
pubmed
36204728
uniprot
proteins
pubmed
9354792
uniprot
proteins
sequence_length
429
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:O55174}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:17349999}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:17349999}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:O35149}. Note=Enriched in vesicles within the basal region of epithelial cells. {ECO:0000250|UniProtKB:O55174}.
uniprot
proteins
transmembrane_region
TRANSMEM 114..134; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 144..164; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 179..199; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 217..237; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 275..295; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 311..331; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins