Rrp8
entrez
101867
canonical
uniprot
Q9DB85
canonical
ensembl
ENSMUSG00000030888
resolver
ensp
ENSMUSP00000033179
resolver
ensp
ENSMUSP00000095752
resolver
enst
ENSMUST00000033179
resolver
enst
ENSMUST00000098148
resolver
genesymbol
Rrp8
resolver
uniprot
E9PVA2
resolver
uniprot
Q3T9X9
resolver
uniprot
Q3TDD7
resolver
uniprot
Q3U3A5
resolver
uniprot
Q8BHW3
resolver
uniprot_entry
E9PVA2_MOUSE
resolver
uniprot_entry
RRP8_MOUSE
resolver
uniprot_sec
Q3T9X9
resolver
uniprot_sec
Q3TDD7
resolver
uniprot_sec
Q3U3A5
resolver
uniprot_sec
Q8BHW3
resolver
amino_acid_sequence
MFEEPEWVEAAPAIVGLGAATAQVRPATAPPVKGRKRRHLLATLRALEAASLSQQTPSLPGSDSEEEEEVGRKKRHLQRPSLASVSKEVGKKRKGKCQKQAPSISDSEGKEIRRKCHRQAPPLGGVSAGEEKGKRKCQEYSSLHLTQPLDSVDQTVHNSRTSTATIDPSKPSPESMSPNSSHTLSRKQWRNRQKNKRRHKNKFRPLQTPEQAPPKASIEETEVPPVPKSDSQESRAGALRARMTQRLDGARFRYLNEQLYSGPSSAARRLFQEDPEAFLLYHRGFQRQVKKWPLHPVDRIAKDLRQKPASLVVADFGCGDCRLASSVRNPVHCFDLASLDPRVTVCDMAQVPLEDESVDVAVFCLSLMGTNIRDFLEEANRVLKTGGLLKVAEVSSRFEDIRTFLGAVTKLGFKIIYKDLTNSHFFLFDFEKTGPPRVGPKAQLSGLKLQPCLYKRR
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
51066
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
protein_family
RRP8 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
457
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}. Note=Localizes at rDNA locus. {ECO:0000250}.
uniprot
proteins