Cdk5rap2
entrez
214444
canonical
uniprot
Q8K389
canonical
ensembl
ENSMUSG00000039298
resolver
ensp
ENSMUSP00000119891
resolver
ensp
ENSMUSP00000196643
resolver
enst
ENSMUST00000144099
resolver
genesymbol
Cdk5rap2
resolver
genesymbol_syn
Kiaa1633
resolver
uniprot
A2AVA1
resolver
uniprot
Q0VGR5
resolver
uniprot
Q6PCN1
resolver
uniprot
Q6ZPL0
resolver
uniprot_entry
CK5P2_MOUSE
resolver
uniprot_entry
Q0VGR5_MOUSE
resolver
uniprot_sec
A2AVA1
resolver
uniprot_sec
Q6PCN1
resolver
uniprot_sec
Q6ZPL0
resolver
amino_acid_sequence
MDSGMEEEGALPGTLSGCSGLHPVLPSDLDVISDTSGLGNGVLPSMSEEKVSPTRARNMKDFENQITELKKENFNLKLRIYFLEERIQQEFAGPTEHIYKTNIELKVEVESLKRELQEKDQLLVKASKAVESLAERGGSEVQRVKEDARKKVQQVEDLLTKRIHLLEEDVKAAQAELEKAFAGTETEKALRLSLESKLSAMKKMQEGDLEMTLALEEKDRLIEELKLSLKSKEALIQCLKEEKSQMASPDENVSSGELRGLSATLREEKERDAEEWQKERNHFEERIQALQEDLREKEREIATEKKNNLKSYKAIQGLTMALKSKEREVEELDSKIKEVTTDSTKGREDPLKTQIPRFQLREGSEDCEAALVEKEALLAKLHSENVTKSTENHRLLRNVKKVTQELNDLKKEKLRLEQALEEAHQEGNRGARTIHDLRNEVEKLRKEVSEREKAVEKHYKSLPGESKTKFHTQEQVVRSLTGSGSQEDLLLQKSNEKDLEAIQQNCYLMTAEELKFGSDGLITEKCSQQSPDSKLIFSKEKQQSEYEGLTGDLKAEQNIYAHLAKTQDTDSVSNLQAELKEVLALRKQLEQDVLAYRNLQKALQEQLSEIRSREEEPFSFYSDQTSYLSICLEEHNQFQLEHFSQEELKKKVSDLIQLVKDLHTDNQHLKKTIFDLSSVGFQGSDRLELTKQEELVASKEDEDTLKFEADVETPFQSDQHLEQSREIMEDYAEGGCKSGYGRHMDSNILGHDGAQTPGASEEHTLEDELLGLLATLFSKKATPLLESRPDLLKALGALLLERICLAEQGRPGDHLDSKTEKALQQVAVQLRDELGHSFPANSFSKSYNEVKSMWGNWLVKTGDEDTVELKSVSVQTMAIEDTPHGFKPQSKRDAWAEKQEEAIFSTELESEALGEMPGQQATHLSFPSAINPDAEKTGLLIQLKTPELLENLYNLPASPEVVVAQLQGQVLELQRELKEFKTRNKQLHEKLILAEAMMEGLPVPNSALVNVPAAQAVVRTAFQDNPGEQEGPETTQSAGRDKDMDSDQYTSFEIDSEICPPDDLALLPACKENLEDLLGPSSIATYLDSKSQLSVKVSVNGTDQSENINIPDDTEDLKQKIHDLQTELEGYRNIIVQLLKHSQCSEAIITVLCGTEGAQDGLNKPKGHIDEEEMTFSSLHQVRYVKHMKILRPLTPEMIDGKMLESLKQQLVDQEQELQKEQDLNLELFGEIHDLQNKFQDLSPSRYDSLVQSQARELSLQRQQIKDSHGICVIYRQHMSTMIKAFEELLQASDVDSCVAEGFREQLTQCAGLLEQLERLFLHGKSARVEPHPQNELLKGLRTVEGNLPYHHLLPESPEPSASHALSDDEMSEKSFLSRDPKPDSDTEKYPAMASHFPQDLLMEHIQEIRTLRKHLEESIKTNEKLRKQLERQGSETDQGSRNVSACGLALHSSLTSEIHFLRKQNEALSMMLEKGSKDKQKESEKLRESLARKAESLEQLQLEYTSVREENERLQRDIIEKERHNQELTEEVCSSRQELSRVQEEAKSRQQLLSQKDKLLQSLQMELKVYEKLAEEHPRLQQDGSKCPEASDNSFDLFESTQAMAPKSASETPLLSGTDVDSLSCDSTSSATSPTSMPCLVAGHHMWASKSGHHMLGLIEDYDALYKQISWGQTLLAKMDVQTQEALSPTSHKLGPKGSSSVPLSKFLSSMNTAKLVLEKASRLLKLFWRVSVPTNGQCSLHCEQIGEMKAENTKLHKKLFEQEKKLQNTAKLLQQSKHQEKVIFDQLVITHQVLRKARGNLELRPGATRPGASSPSRPGS
uniprot
proteins
function
FUNCTION: Potential regulator of CDK5 activity via its interaction with CDK5R1 (By similarity). Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion (PubMed:20627074). Involved in regulation of mitotic spindle orientation (PubMed:20460369). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter (By similarity). Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends (By similarity). Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gTuRC) onto centrosomes (By similarity). Required for the recruitment of AKAP9 to centrosomes (By similarity). Plays a role in neurogenesis (PubMed:20471352). Contrary to higher mammalian orthologs, including human, chimpanzee, bovine and dog, does not interact with EB1/MAPRE1, therefore its function in the regulation of microtubule dynamics is unclear (PubMed:19553473). {ECO:0000250|UniProtKB:Q96SN8, ECO:0000269|PubMed:19553473, ECO:0000269|PubMed:20460369, ECO:0000269|PubMed:20471352, ECO:0000269|PubMed:20627074}.
uniprot
proteins
mass_dalton
205945
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in vitro by CDK5. {ECO:0000250|UniProtKB:Q9JLH5}.
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19553473
uniprot
proteins
pubmed
20460369
uniprot
proteins
pubmed
20466722
uniprot
proteins
pubmed
20471352
uniprot
proteins
pubmed
20627074
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1822
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20466722, ECO:0000269|PubMed:20471352, ECO:0000269|PubMed:20627074, ECO:0000305|PubMed:19553473}. Golgi apparatus {ECO:0000250|UniProtKB:Q96SN8}. Cytoplasm {ECO:0000250|UniProtKB:Q96SN8}. Note=Found in the pericentriolar region adhering to the surface of the centrosome and in the region of the centrosomal appendages. Due to the lack of interaction with EB1/MAPRE1, its localization to microtubule plus ends may not be conserved in mice (Probable). Localization to centrosomes versus Golgi apparatus may be cell type-dependent (By similarity). {ECO:0000250|UniProtKB:Q96SN8, ECO:0000305|PubMed:19553473}.
uniprot
proteins