HDAC10
entrez
83933
canonical
uniprot
Q969S8
canonical
ensembl
ENSG00000100429
resolver
ensp
ENSP00000216271
resolver
ensp
ENSP00000343540
resolver
genesymbol
HDAC10
resolver
hgnc
HGNC:18128
resolver
uniprot
Q08AP4
resolver
uniprot
Q6STF9
resolver
uniprot
Q96P77
resolver
uniprot
Q96P78
resolver
uniprot
Q9H028
resolver
uniprot
Q9UGX1
resolver
uniprot
Q9UGX2
resolver
uniprot_entry
HDA10_HUMAN
resolver
uniprot_sec
Q08AP4
resolver
uniprot_sec
Q6STF9
resolver
uniprot_sec
Q96P77
resolver
uniprot_sec
Q96P78
resolver
uniprot_sec
Q9H028
resolver
uniprot_sec
Q9UGX1
resolver
uniprot_sec
Q9UGX2
resolver
amino_acid_sequence
MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIAATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALSMFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGLAGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKMLQCHPHLVA
uniprot
proteins
disease_involvement
DISEASE: Note=In neuroblastoma cells, may promote autophagy in response to chemotherapy-induced DNA damage and efflux of chemotherapeutics via lysosomal exocytosis, hence protecting cells from cytotoxic agents (PubMed:23801752, PubMed:29968769). Expression levels may correlate with survival in neuroblastoma patients, with low levels in the tumor correlating with long-term patient survival and high expression with poor prognosis (PubMed:23801752). Therefore has been proposed as a biomarker to predict neuroblastoma chemoresistance and treatment outcome (PubMed:23801752). {ECO:0000269|PubMed:23801752, ECO:0000269|PubMed:29968769, ECO:0000303|PubMed:23801752}.
uniprot
proteins
ec_number
3.5.1.48
uniprot
proteins
ec_number
3.5.1.62
uniprot
proteins
function
FUNCTION: Polyamine deacetylase (PDAC), which acts preferentially on N(8)-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954). Exhibits attenuated catalytic activity toward N(1),N(8)-diacetylspermidine and very low activity, if any, toward N(1)-acetylspermidine (PubMed:28516954). Histone deacetylase activity has been observed in vitro (PubMed:11677242, PubMed:11726666, PubMed:11739383, PubMed:11861901). Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039). The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed:28516954). May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed:23801752, PubMed:29968769). May play a role in homologous recombination (PubMed:21247901). May promote DNA mismatch repair (PubMed:26221039). {ECO:0000269|PubMed:11677242, ECO:0000269|PubMed:11726666, ECO:0000269|PubMed:11739383, ECO:0000269|PubMed:11861901, ECO:0000269|PubMed:21247901, ECO:0000269|PubMed:23801752, ECO:0000269|PubMed:26221039, ECO:0000269|PubMed:28516954, ECO:0000269|PubMed:29968769}.
uniprot
proteins
mass_dalton
71445
uniprot
proteins
mutagenesis
MUTAGEN 135; /note="H->A: Abolishes deacetylase activity. Does not affect interaction with HDAC3. Loss of autophagy regulation."; /evidence="ECO:0000269|PubMed:11726666, ECO:0000269|PubMed:11861901, ECO:0000269|PubMed:23801752
uniprot
proteins
protein_family
HD type 2 subfamily
uniprot
proteins
protein_family
Histone deacetylase family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
11677242
uniprot
proteins
pubmed
11726666
uniprot
proteins
pubmed
11739383
uniprot
proteins
pubmed
11861901
uniprot
proteins
pubmed
14759258
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21247901
uniprot
proteins
pubmed
23801752
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26221039
uniprot
proteins
pubmed
28516954
uniprot
proteins
pubmed
29968769
uniprot
proteins
sequence_length
669
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11677242, ECO:0000269|PubMed:11726666, ECO:0000269|PubMed:11739383, ECO:0000269|PubMed:11861901, ECO:0000269|PubMed:23801752}. Nucleus {ECO:0000269|PubMed:11677242, ECO:0000269|PubMed:11726666, ECO:0000269|PubMed:11739383, ECO:0000269|PubMed:11861901}. Note=Excluded from nucleoli. {ECO:0000269|PubMed:11726666}.
uniprot
proteins