Plpp6
entrez
619549
canonical
uniprot
Q66H88
canonical
ensembl
ENSRNOG00000015268
resolver
ensembl
ENSRNOG00055032101
resolver
ensembl
ENSRNOG00060030797
resolver
ensembl
ENSRNOG00065027005
resolver
ensp
ENSRNOP00000020475
resolver
ensp
ENSRNOP00000095820
resolver
ensp
ENSRNOP00000102768
resolver
ensp
ENSRNOP00000105378
resolver
ensp
ENSRNOP00000106422
resolver
ensp
ENSRNOP00055045787
resolver
ensp
ENSRNOP00060044433
resolver
ensp
ENSRNOP00065038200
resolver
enst
ENSRNOT00000020475
resolver
enst
ENSRNOT00000113241
resolver
enst
ENSRNOT00000131126
resolver
enst
ENSRNOT00000135959
resolver
enst
ENSRNOT00000155408
resolver
enst
ENSRNOT00055055492
resolver
enst
ENSRNOT00060053488
resolver
enst
ENSRNOT00065046573
resolver
genesymbol
Plpp6
resolver
uniprot_entry
PLPP6_RAT
resolver
amino_acid_sequence
MPSPRRTIEGRPLGSSGGSSVPGSPAHGGGGGGSGRFEFQSLLSCRSGADPACARLRASDSPVHRRGSFPLAAACPAQVAPAPPPEDAGMNLNPSFLGIALRSLLAIDLWLSKKLGVCAGESSAWGSVRPLMKLLEISGHGIPWLLGTLYCLLRSDSWAGREVLMNLLFALLLDLLLVAVIKGLVRRRRPAHNQMDMFFTLSVDKYSFPSGHATRAALVSRFILNHLVLAIPLRVLVVLWAFVLGLSRVMLGRHNVTDVAFGFFLGYMQYSIVDYCWLSPLNVPVLFVLWNQQ
uniprot
proteins
ec_number
3.1.3.-
uniprot
proteins
ec_number
3.6.1.-
uniprot
proteins
ec_number
3.6.1.68
uniprot
proteins
function
FUNCTION: Magnesium-independent polyisoprenoid diphosphatase that catalyzes the sequential dephosphorylation of presqualene, farnesyl, geranyl and geranylgeranyl diphosphates. Functions in the innate immune response through the dephosphorylation of presqualene diphosphate which acts as a potent inhibitor of the signaling pathways contributing to polymorphonuclear neutrophils activation. May regulate the biosynthesis of cholesterol and related sterols by dephosphorylating presqualene and farnesyl diphosphate, two key intermediates in this biosynthetic pathway. May also play a role in protein prenylation by acting on farnesyl diphosphate and its derivative geranylgeranyl diphosphate, two precursors for the addition of isoprenoid anchors to membrane proteins. Has a lower activity towards phosphatidic acid (PA), but through phosphatidic acid dephosphorylation may participate in the biosynthesis of phospholipids and triacylglycerols. May also act on ceramide-1-P, lysophosphatidic acid (LPA) and sphing-4-enine 1-phosphate/sphingosine-1-phosphate. {ECO:0000250|UniProtKB:Q8IY26}.
uniprot
proteins
mass_dalton
31700
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by PKC activates the phosphatase activity towards presqualene diphosphate. {ECO:0000250|UniProtKB:Q8IY26}.
uniprot
proteins
protein_family
PA-phosphatase related phosphoesterase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
293
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8IY26}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8IY26}. Nucleus envelope {ECO:0000250|UniProtKB:Q8IY26}. Nucleus inner membrane {ECO:0000250|UniProtKB:Q8IY26}.
uniprot
proteins
transmembrane_region
TRANSMEM 133..153; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 163..183; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 227..247; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 270..290; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins