Pdlim5
entrez
64353
canonical
uniprot
Q62920
canonical
ensembl
ENSRNOG00000016419
resolver
ensp
ENSRNOP00000022387
resolver
ensp
ENSRNOP00000091892
resolver
ensp
ENSRNOP00000091918
resolver
ensp
ENSRNOP00000093276
resolver
ensp
ENSRNOP00000094742
resolver
ensp
ENSRNOP00000097787
resolver
enst
ENSRNOT00000022387
resolver
enst
ENSRNOT00000106810
resolver
enst
ENSRNOT00000109323
resolver
enst
ENSRNOT00000115772
resolver
genesymbol
Pdlim5
resolver
genesymbol_syn
Enh
resolver
uniprot
A0A8I6B1G1
resolver
uniprot
A0A8I6GJC1
resolver
uniprot
A0A8I6GJY3
resolver
uniprot
A0A8L2QCL7
resolver
uniprot_entry
A0A8I6B1G1_RAT
resolver
uniprot_entry
A0A8I6GJC1_RAT
resolver
uniprot_entry
A0A8I6GJY3_RAT
resolver
uniprot_entry
A0A8L2QCL7_RAT
resolver
uniprot_entry
PDLI5_RAT
resolver
amino_acid_sequence
MSNYNVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKASQAHVRIGDVVLSIDGISAQGMTHLEAQNKIKACTGSLNMTLQRASAAAKSEPVAVQKGEPKEVVKPVPITSPAVSKVTSTTNMAYNKVPRPFGSVSSPKVTSIPSPSSAFTPAHAATSSHASPPPVAAVTPPPLSASGLHASANPSAAQCSSPPNTGKPAVHVPRQPTVTSVCSESAQELAEGQRRGSQGDIKQQNGPPRKHIVERNTEFYHIPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQITGTEHLKESENDNAKKANSTPEPSQQSASPLSAAESLESPGSNRPVVAGLRSAAAFKPVGSTSVKSPSWQRPNQAAPSTGRISNSASSSGTGAPMKPAVGPPQPSDQDTLVQRAEHIPAGKRTPMCAHCNQAIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVINALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICRGCEFPIEAGDMFLEALGSTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAHSVNF
uniprot
proteins
function
FUNCTION: May play an important role in the heart development by scaffolding PKC to the Z-disk region (PubMed:20097676, PubMed:8940095). May play a role in the regulation of cardiomyocyte expansion (PubMed:20097676). Isoforms lacking the LIM domains may negatively modulate the scaffolding activity of isoform 1 (PubMed:20097676). Overexpression promotes the development of heart hypertrophy. Contributes to the regulation of dendritic spine morphogenesis in neurons (PubMed:20097676). May be required to restrain postsynaptic growth of excitatory synapses. Isoform 1, but not isoform 2, expression favors spine thinning and elongation (PubMed:19900557). {ECO:0000269|PubMed:19900557, ECO:0000269|PubMed:20097676, ECO:0000269|PubMed:8940095}.
uniprot
proteins
mass_dalton
63201
uniprot
proteins
pubmed
10833443
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
19900557
uniprot
proteins
pubmed
20097676
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8940095
uniprot
proteins
sequence_length
591
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Postsynaptic density {ECO:0000269|PubMed:19900557}. Presynapse {ECO:0000269|PubMed:19900557}. Postsynapse {ECO:0000269|PubMed:19900557}. Cytoplasm, cytosol {ECO:0000269|PubMed:19900557}. Note=Detected both at presynaptic and postsynaptic sites, exclusively at excitatory synapses, but not inhibitory synapses, in hippocampal neurons. {ECO:0000269|PubMed:19900557}.; SUBCELLULAR LOCATION: [Isoform 2]: Postsynaptic density {ECO:0000269|PubMed:19900557}. Presynapse {ECO:0000269|PubMed:19900557}. Postsynapse {ECO:0000269|PubMed:19900557}. Cytoplasm, cytosol {ECO:0000269|PubMed:19900557}. Note=Detected both at presynaptic and postsynaptic sites, exclusively at excitatory synapses, but not inhibitory synapses, in hippocampal neurons. {ECO:0000269|PubMed:19900557}.
uniprot
proteins