Socs6
entrez
54607
canonical
uniprot
Q9JLY0
canonical
ensembl
ENSMUSG00000056153
resolver
ensp
ENSMUSP00000064929
resolver
ensp
ENSMUSP00000114993
resolver
ensp
ENSMUSP00000118764
resolver
enst
ENSMUST00000070116
resolver
enst
ENSMUST00000123826
resolver
enst
ENSMUST00000125362
resolver
genesymbol
Socs6
resolver
genesymbol_syn
Cis4
resolver
genesymbol_syn
Cish4
resolver
genesymbol_syn
Socs4
resolver
uniprot
Q8VEN5
resolver
uniprot
Q9D2A0
resolver
uniprot_entry
SOCS6_MOUSE
resolver
uniprot_sec
Q8VEN5
resolver
uniprot_sec
Q9D2A0
resolver
amino_acid_sequence
MKKISLKTFRKSFNLSKSKDETEFMVVQPQSLAGDFVKDDSLFGSCYGKDMASCDIGSEDEKGKNRSKSESLMGTLKRRLSAKQKTKGKGGTASTDEDTFSSASAPGGLKDVRAPRPIRSTSLRSHHYSPTPWPLRPTSSEETCIKMEMRVKALVHAASPGPVNGVRKDLRELQPRELRDLQPEPRPESRCSPSSPGDLSLHLEEHVPVVIGLMSQDYLQYTVPLDDGMCPLEGPRSCCLDTSSPMEVSAVPLPGASGAFSEDDSHVDQDLVVGPEILVDSSVNNLLIGTTGVMLQSPRGGHDDAPPLSPLLPPMQNNPIQRNFSGLSGPDLHMAESVRCHLNFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY
uniprot
proteins
function
FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor (By similarity). {ECO:0000250, ECO:0000269|PubMed:16643902}.
uniprot
proteins
mass_dalton
59077
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
12052866
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16643902
uniprot
proteins
pubmed
21099329
uniprot
proteins
sequence_length
533
uniprot
proteins