Lrsam1
entrez
227738
canonical
uniprot
Q80ZI6
canonical
ensembl
ENSMUSG00000026792
resolver
ensp
ENSMUSP00000028132
resolver
ensp
ENSMUSP00000108825
resolver
ensp
ENSMUSP00000278738
resolver
ensp
ENSMUSP00000278740
resolver
ensp
ENSMUSP00000278745
resolver
ensp
ENSMUSP00000278748
resolver
ensp
ENSMUSP00000278750
resolver
ensp
ENSMUSP00000278755
resolver
ensp
ENSMUSP00000278759
resolver
ensp
ENSMUSP00000278761
resolver
ensp
ENSMUSP00000278763
resolver
ensp
ENSMUSP00000278773
resolver
ensp
ENSMUSP00000278776
resolver
ensp
ENSMUSP00000278782
resolver
enst
ENSMUST00000028132
resolver
enst
ENSMUST00000113200
resolver
genesymbol
Lrsam1
resolver
uniprot_entry
LRSM1_MOUSE
resolver
amino_acid_sequence
MPLFFRKRKPSEEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVLIVHTNHLTSLLPKSCSLLSLVTIKVLDLHENQLTALPDDMGQLTVLQVLNVERNQLTHLPRSIGNLLQLQTLNVKDNKLKELPDTLGELRSLRTLDISENEIQRLPQMLAHVRTLETLSLNALAMVYPPPEVCGAGTAAVQQFLCKESGLDYYPPSQYLLPVLEQDGAENTQDSPDGPASRFSREEAEWQNRFSDYEKRKEQKMLEKLEFERRLDLGQREHAELLQQSHSHKDEILQTVKQEQTRLEQDLSERQRCLDAERQQLQEQLKQTEQSIASRIQRLLQDNQRQKKSSEILKSLENERIRMEQLMSITQEETENLRQREIAAAMQQMLTESCKSRLIQMAYESQRQSLAQQACSSMAEMDKRFQQILSWQQMDQNKAISQILQESVMQKAAFEALQVKKDLMHRQIRNQIRLIETELLQLTQLELKRKSLDTETLQEMVSEQRWALSNLLQQLLKEKKQREEELHGILAELEAKSETKQENYWLIQYQRLLNQKPLSLKLQEEGMERRLVALLVELSAEHYLPLFAHHRISLDMLSRMSPGDLAKVGVSEAGLQHEILRRAQDLLAVPRVQPELKPLENEVLGALEPPTAPRELQESVRPSAPPAELDMPTSECVVCLEREAQMVFLTCGHVCCCQQCCQPLRTCPLCRQEISQRLRIYHSS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (viral proteins) cargos (By similarity). Bacterial recognition protein that defends the cytoplasm from invasive pathogens (By similarity). Localizes to several intracellular bacterial pathogens and generates the bacteria-associated ubiquitin signal leading to autophagy-mediated intracellular bacteria degradation (xenophagy) (By similarity). {ECO:0000250|UniProtKB:Q6UWE0}.
uniprot
proteins
mass_dalton
83976
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q6UWE0}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitination promoted by PHF23 leads to proteasomal degradation. {ECO:0000250|UniProtKB:Q6UWE0}.
uniprot
proteins
pubmed
15256501
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
727
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6UWE0}. Note=Displays a punctuate distribution and localizes to a submembranal ring (PubMed:15256501). Localizes to intracellular bacterial pathogens (By similarity). {ECO:0000250|UniProtKB:Q6UWE0}.
uniprot
proteins