PEX39
entrez
441150
canonical
uniprot
Q5I0X4
canonical
ensembl
ENSG00000221821
resolver
ensp
ENSP00000386146
resolver
enst
ENST00000408925
resolver
genesymbol
PEX39
resolver
genesymbol_syn
C6orf226
resolver
hgnc
HGNC:34431
resolver
uniprot_entry
PEX39_HUMAN
resolver
amino_acid_sequence
MERPRSPQCSAPASASASVTLAQLLQLVQQGQELPGLEKRHIAAIHGEPTASRLPRRPKPWEAAALAESLPPPTLRIGTAPAEPGLVEAATAPSSWHTVGP
uniprot
proteins
function
FUNCTION: Cytosolic peroxin that promotes the peroxisomal import of proteins containing a type-2 peroxisomal targeting signal (PTS2) by binding to PEX7 and stabilizing its interaction with PTS2-containing cargo (PubMed:37160800, PubMed:40739340). PEX39 subsequently transfers the PEX7-cargo complex to PEX13 at the peroxisomal membrane, enabling PEX7 to bind PEX13 and facilitating translocation of PTS2-containing proteins into the peroxisome. Both PEX39 and PEX13 contain a conserved KPWE motif, which enables competitive binding to PEX7 and ensures efficient handover of the complex (PubMed:40739340). {ECO:0000269|PubMed:37160800, ECO:0000269|PubMed:40739340}.
uniprot
proteins
mass_dalton
10566
uniprot
proteins
mutagenesis
MUTAGEN 59..62; /note="KPWE->AAAA: Abolishes interaction with PEX7."; /evidence="ECO:0000269|PubMed:40739340
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
37160800
uniprot
proteins
pubmed
40739340
uniprot
proteins
sequence_length
101
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:40739340}.
uniprot
proteins