TSSC4
entrez
10078
canonical
uniprot
Q9Y5U2
canonical
ensembl
ENSG00000184281
resolver
ensp
ENSP00000331087
resolver
ensp
ENSP00000370384
resolver
ensp
ENSP00000537368
resolver
ensp
ENSP00000537370
resolver
ensp
ENSP00000537373
resolver
genesymbol
TSSC4
resolver
hgnc
HGNC:12386
resolver
uniprot
C9JS66
resolver
uniprot
Q86VL2
resolver
uniprot
Q9BRS6
resolver
uniprot_entry
TSSC4_HUMAN
resolver
uniprot_sec
C9JS66
resolver
uniprot_sec
Q86VL2
resolver
uniprot_sec
Q9BRS6
resolver
amino_acid_sequence
MAEAGTGEPSPSVEGEHGTEYDTLPSDTVSLSDSDSDLSLPGGAEVEALSPMGLPGEEDSGPDEPPSPPSGLLPATVQPFHLRGMSSTFSQRSRDIFDCLEGAARRAPSSVAHTSMSDNGGFKRPLAPSGRSPVEGLGRAHRSPASPRVPPVPDYVAHPERWTKYSLEDVTEVSEQSNQATALAFLGSQSLAAPTDCVSSFNQDPSSCGEGRVIFTKPVRGVEARHERKRVLGKVGEPGRGGLGNPATDRGEGPVELAHLAGPGSPEAEEWGSHHGGLQEVEALSGSVHSGSVPGLPPVETVGFHGSRKRSRDHFRNKSSSPEDPGAEV
uniprot
proteins
function
FUNCTION: Protein associated with the U5 snRNP, during its maturation and its post-splicing recycling and which is required for spliceosomal tri-snRNP complex assembly in the nucleus (PubMed:34131137, PubMed:35188580). Has a molecular sequestering activity and transiently hinders SNRNP200 binding sites for constitutive splicing factors that intervene later during the assembly of the spliceosome and splicing (PubMed:35188580). Together with its molecular sequestering activity, may also function as a molecular adapter and placeholder, coordinating the assembly of the U5 snRNP and its association with the U4/U6 di-snRNP (PubMed:34131137). {ECO:0000269|PubMed:34131137, ECO:0000269|PubMed:35188580}.
uniprot
proteins
mass_dalton
34326
uniprot
proteins
mutagenesis
MUTAGEN 162; /note="W->A: Loss of interaction with PRPF8 and SNRNP200; when associated with A-165, A-201, A-202, A-315 and A-316."; /evidence="ECO:0000269|PubMed:35188580"; MUTAGEN 165; /note="Y->A: Loss of interaction with PRPF8 and SNRNP200; when associated with A-162, A-201, A-202, A-315 and A-316."; /evidence="ECO:0000269|PubMed:35188580"; MUTAGEN 201; /note="F->A: Loss of interaction with SNRNP200; when associated with A-202, A-315 and A-316. Loss of interaction with PRPF8 and SNRNP200; when associated with A-162, A-165, A-202, A-315 and A-316."; /evidence="ECO:0000269|PubMed:35188580"; MUTAGEN 202; /note="N->A: Loss of interaction with SNRNP200; when associated with A-201, A-315 and A-316. Loss of interaction with PRPF8 and SNRNP200; when associated with A-162, A-165, A-201, A-315 and A-316."; /evidence="ECO:0000269|PubMed:35188580"; MUTAGEN 315; /note="F->A: Loss of interaction with SNRNP200; when associated with A-201, A-202 and A-316. Loss of interaction with PRPF8 and SNRNP200; when associated with A-162, A-165, A-201, A-202 and A-316."; /evidence="ECO:0000269|PubMed:35188580"; MUTAGEN 316; /note="R->A: Loss of interaction with SNRNP200; when associated with A-201, A-202 and A-315. Loss of interaction with PRPF8 and SNRNP200; when associated with A-162, A-165, A-201, A-202 and A-315."; /evidence="ECO:0000269|PubMed:35188580
uniprot
proteins
protein_family
TSSC4 family
uniprot
proteins
pubmed
10072438
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
34131137
uniprot
proteins
pubmed
35188580
uniprot
proteins
sequence_length
329
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:34131137}. Cytoplasm {ECO:0000269|PubMed:34131137}. Note=Shuttles between the cytoplasm and the nucleus, associated with the U5 snRNP. {ECO:0000269|PubMed:34131137}.
uniprot
proteins