TNK2
entrez
10188
canonical
uniprot
Q07912
canonical
ensembl
ENSG00000061938
resolver
ensp
ENSP00000329425
resolver
ensp
ENSP00000371341
resolver
ensp
ENSP00000392546
resolver
ensp
ENSP00000499858
resolver
ensp
ENSP00000499899
resolver
ensp
ENSP00000500238
resolver
ensp
ENSP00000500452
resolver
ensp
ENSP00000500486
resolver
ensp
ENSP00000500887
resolver
ensp
ENSP00000503221
resolver
ensp
ENSP00000533962
resolver
ensp
ENSP00000533963
resolver
ensp
ENSP00000533964
resolver
ensp
ENSP00000533966
resolver
ensp
ENSP00000533967
resolver
ensp
ENSP00000533968
resolver
ensp
ENSP00000533969
resolver
ensp
ENSP00000533970
resolver
ensp
ENSP00000533973
resolver
ensp
ENSP00000633995
resolver
enst
ENST00000381916
resolver
enst
ENST00000428187
resolver
enst
ENST00000672024
resolver
enst
ENST00000672887
resolver
enst
ENST00000673038
resolver
enst
ENST00000673420
resolver
enst
ENST00000678220
resolver
enst
ENST00000863903
resolver
enst
ENST00000863904
resolver
enst
ENST00000863907
resolver
enst
ENST00000863908
resolver
enst
ENST00000863909
resolver
enst
ENST00000863911
resolver
enst
ENST00000863914
resolver
enst
ENST00000963936
resolver
genesymbol
TNK2
resolver
genesymbol_syn
ACK1
resolver
hgnc
HGNC:19297
resolver
uniprot
A0A499FJ16
resolver
uniprot
A0A5F9ZGX5
resolver
uniprot
A0A5F9ZHJ2
resolver
uniprot
A0A5F9ZHP4
resolver
uniprot
A0A5F9ZI29
resolver
uniprot
B3KXJ4
resolver
uniprot
C9J1X3
resolver
uniprot
Q6ZMQ0
resolver
uniprot
Q8N6U7
resolver
uniprot
Q96H59
resolver
uniprot_entry
A0A499FJ16_HUMAN
resolver
uniprot_entry
A0A5F9ZGX5_HUMAN
resolver
uniprot_entry
A0A5F9ZHJ2_HUMAN
resolver
uniprot_entry
A0A5F9ZHP4_HUMAN
resolver
uniprot_entry
A0A5F9ZI29_HUMAN
resolver
uniprot_entry
ACK1_HUMAN
resolver
uniprot_entry
B3KXJ4_HUMAN
resolver
uniprot_entry
C9J1X3_HUMAN
resolver
uniprot_sec
Q6ZMQ0
resolver
uniprot_sec
Q8N6U7
resolver
uniprot_sec
Q96H59
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by AIM-100 (4-amino-5,6-biaryl-furo[2,3-d]pyrimidine), which suppresses activating phosphorylation at Tyr-284. Repressed by dasatinib. {ECO:0000269|PubMed:20383201, ECO:0000269|PubMed:20623637}.
uniprot
proteins
amino_acid_sequence
MQPEEGTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKRRKALCKRKSWMSKVFSGKRLEAEFPPHHSQSTFRKTSPAPGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRAENYWWRGQNTRTLCVGPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCWGFPDRIDELYLGNPMDPPDLLSVELSTSRPPQHLGGVKKPTYDPVSEDQDPLSSDFKRLGLRKPGLPRGLWLAKPSARVPGTKASRGSGAEVTLIDFGEEPVVPALRPCAPSLAQLAMDACSLLDETPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEICSINSTLVGAGVPAGPSQGQTNYAFVPEQARPPPPLEDNLFLPPQGGGKPPSSAQTAEIFQALQQECMRQLQAPAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPPREPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRAGPCILPIVRDGKKVSSTHYYLLPERPSYLERYQRFLREAQSPEEPTPLPVPLLLPPPSTPAPAAPTATVRPMPQAALDPKANFSTNNSNPGARPPPPRATARLPQRGCPGDGPEAGRPADKIQMAMVHGVTTEECQAALQCHGWSVQRAAQYLKVEQLFGLGLRPRGECHKVLEMFDWNLEQAGCHLLGSWGPAHHKR
uniprot
proteins
ec_number
2.7.10.2
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed:20110370). {ECO:0000269|PubMed:10652228, ECO:0000269|PubMed:11278436, ECO:0000269|PubMed:16247015, ECO:0000269|PubMed:16257963, ECO:0000269|PubMed:16472662, ECO:0000269|PubMed:17038317, ECO:0000269|PubMed:18262180, ECO:0000269|PubMed:18435854, ECO:0000269|PubMed:19815557, ECO:0000269|PubMed:20110370, ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20383201}.
uniprot
proteins
mass_dalton
114569
uniprot
proteins
mutagenesis
MUTAGEN 120; /note="L->Q: No effect on autophosphorylation at Y-284."; /evidence="ECO:0000269|PubMed:20110370"; MUTAGEN 158; /note="K->R: Loss of autophosphorylation at Y-284."; /evidence="ECO:0000269|PubMed:16288044, ECO:0000269|PubMed:20110370"; MUTAGEN 197; /note="L->Q: No effect on autophosphorylation at Y-284."; /evidence="ECO:0000269|PubMed:20110370"; MUTAGEN 365; /note="V->R: Increased autophosphorylation at Y-284."; /evidence="ECO:0000269|PubMed:20110370"; MUTAGEN 487; /note="L->F: Constantly active kinase."; /evidence="ECO:0000269|PubMed:16288044
uniprot
proteins
post_translational_modification
PTM: Autophosphorylation regulates kinase activity. Phosphorylation on Tyr-518 is required for interaction with SRC and is observed during association with clathrin-coated pits. {ECO:0000269|PubMed:15308621, ECO:0000269|PubMed:16472662, ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20623637, ECO:0000269|PubMed:20979614, ECO:0000269|PubMed:21169560, ECO:0000269|PubMed:21309750}.; PTM: Polyubiquitinated by NEDD4 and NEDD4L. Degradation can be induced by EGF and is lysosome-dependent (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
10360579
uniprot
proteins
pubmed
10587647
uniprot
proteins
pubmed
10652228
uniprot
proteins
pubmed
11278436
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14733946
uniprot
proteins
pubmed
15308621
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16137687
uniprot
proteins
pubmed
16247015
uniprot
proteins
pubmed
16257963
uniprot
proteins
pubmed
16288044
uniprot
proteins
pubmed
16472662
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17038317
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17494760
uniprot
proteins
pubmed
18262180
uniprot
proteins
pubmed
18435854
uniprot
proteins
pubmed
18477472
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
18993068
uniprot
proteins
pubmed
19144635
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19815557
uniprot
proteins
pubmed
20110370
uniprot
proteins
pubmed
20333297
uniprot
proteins
pubmed
20383201
uniprot
proteins
pubmed
20432460
uniprot
proteins
pubmed
20623637
uniprot
proteins
pubmed
20979614
uniprot
proteins
pubmed
21169560
uniprot
proteins
pubmed
21309750
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23686771
uniprot
proteins
pubmed
8497321
uniprot
proteins
sequence_length
1038
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20333297, ECO:0000269|PubMed:20979614}. Nucleus {ECO:0000269|PubMed:14733946, ECO:0000269|PubMed:20333297}. Endosome {ECO:0000250|UniProtKB:O54967}. Cell junction, adherens junction {ECO:0000305}. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side {ECO:0000269|PubMed:16137687}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000269|PubMed:16137687, ECO:0000269|PubMed:18262180}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:21169560}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:20110370}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:O54967}. Note=The Tyr-284 phosphorylated form is found both in the membrane and nucleus (By similarity). Co-localizes with EGFR on endosomes (PubMed:20333297). Nuclear translocation is CDC42-dependent (By similarity). Detected in long filamentous cytosolic structures where it co-localizes with CTPS1 (By similarity). {ECO:0000250|UniProtKB:O54967, ECO:0000269|PubMed:20333297}.
uniprot
proteins