Muc4
entrez
140474
canonical
uniprot
Q8JZM8
canonical
ensembl
ENSMUSG00000118672
resolver
ensp
ENSMUSP00000159443
resolver
enst
ENSMUST00000239554
resolver
genesymbol
Muc4
resolver
uniprot
A0A7N9VSW1
resolver
uniprot
Q4VAA3
resolver
uniprot
Q9ERB8
resolver
uniprot
Q9QXG0
resolver
uniprot
Q9WV36
resolver
uniprot_entry
A0A7N9VSW1_MOUSE
resolver
uniprot_entry
MUC4_MOUSE
resolver
uniprot_sec
Q4VAA3
resolver
uniprot_sec
Q9ERB8
resolver
uniprot_sec
Q9QXG0
resolver
uniprot_sec
Q9WV36
resolver
amino_acid_sequence
MRGPHWRVPWLCLSCLYSCLLLLPDALATTSTQTPMSLSSSTRTSQMSSQASTSSTSSDRRTSKTEQTSTRDTPSSITTVSQSHHTTSMETSKPQTTTTTEVTTSTPSASSRDQIQTETSSQRTISPDGTTTSHAPSISSSAPSTTHMLTTTSSTESTSVDSGHTTAITTQGLTPATAQVSLTPSSQNMSTVSTPITSTLTQRQHTGSKQTSSKSQVNIVTSTLSTSTSDSTPAQTMSQVTSSSDKRTKPSTSGVSSTSLTTTEVLTQTSSTDSAPGNTTLRITQNSTTHTTKVSTTSTPQKLSPVSTLINSSQKMSTLPQNQHTESMDTSRQPQTTTTIEVTTSTPSASSLHQIQTETNSPKTISPGETTTSHAPNMRSSPPKTSQILTTMPSTKSTSVDTKQTKAITTKVSTPDTTQVSMTPSSQKLPTHSTSTQELTSSYSQHIQSKGTSSKSQTTTNTKVNTSTPSASSRDKIQTETSSQRTNSPGEKRTSHAPSMSSSAPSTTHMLSTTSSNQSTSVDTGQTTSVTAQGSTPAITQTSLTPSSQNTSTVSTPITSTHKLSTLSQSQHTGSKGTSSNPQTTTTTEVTTSTPSATTHDQIQTETSSQNTISPGETTTSYAPIMSSSAPSTTHMLSTTSSTQSTSVDTRHTTTLTNQGSTPATTQVSPSSQNMSTVSAPITSTQILSTFPQSQHTGSKGTSSNPQTTTTPVVTTSNPSATSRDQIQTETSSQRTISPGETTTSYASIMSSSAPSTTHMLTTTSSTQSTSVDTRHTIAVRTQGSTPATTQVSPSSQNMSTVSTPITSTQILSTLPQSQHTGSKGTSSNPQTTTSPVVTTSTPSGTSGDQIQTETSSQRTISPGKTTTSHALNINSSAPSTTHMLSTTSSTQSTSGDTRHTTAGRTQGSTPATTQVSPSSQNMSTVSAPITSIQMLSTLPQSQHTESKSTSTNPQTTTTPEVTTSNPSATSHDQIETETSSQRTISPGETTTSYAPIMSSSAPSTTHMLSTTSSTQSTSVDTRNTTTLTTQGSTPATTQVSPSSKNMSTVSTPITSTHKLSTLPQSQHTGSNGTSSSSSTPATHRSHLHPNMSTVSTPITTTHKLSTLSQSQHTGSKGTSSNPQTTTTPVMTTSTPSATTHDQIQTETSSQRTISHGETTTSYAPIMSSSAPSTTHMLSTASSTQITSVDTRHTTAITTQGSTPATTQVSPSSQNMSTVSAPITSIQILSTLPQSQHTGSKGTSTNPQTTTTPEVTTSTPSATSRDQIQTETSSQRTISPGETTTSHAPIMSSSAPSTTHMLSTTSSTQSTSVDTRHTTAGRTQGSTPATTQVSPSSQNMTTTSHALMSSSAPSTTHMLSTTSSTQSTSVDTRHTTTVTTQGSTPATTQVLPSSQNMSTVSAPITSTQILSTLPQSQHTGSKGTSTNPQTTTNAEVTTSTPSATSHDQIETETSSQRTISPGETTTSHAPNMSSSAPSTTHMLSSTSSTQITSVDTGHTSAGRTQGSTPATTQVSPSSQNMSTVSAPITSTHILSTLPKSQHTGSKGTSSNPQTTITPVVTTSTPSASSRDQIQTETSFQRTISPGETTTSHAPSMSSSAPSSTHMLSTASSTQITSVDTRHTTAITTQGSTPATTQVSPSSQNMSTVSAPITSIQMLSTLPQSQHTESKSTSTNPQTTTTPRVTTSTPSASSRDQIQTETSSQRTISPGKTTTSHVPNMNSSAPSTTHILSTTSSIQSTSGDTRHTTAVRTQGSTPATTQVSLAPSSQNMSTLSAPITSPQHFSTLPQNQHTGSMGTSSNPQSTTIPEVTTSTLSASSRDQVQTETSSQRTISPGETTTSHASSLSSSAPSSTHMLSTASSTEITSGDTRHTTAIVTQGSTPATTQTTLTPSSQNMSTVSTPITSTHKLSPLPQSQHTENMGTSSNPQTTTTPEVTTSTPSATSYDQIQTETSFQRTISPGETTTSHAPSMSNSAPSSTHKLSTASSTEITSVDTRHTIAITTQGSTLATTQTSLTPSSQNMSTVSAPITSSQILSTLRQSQHTGSKGTSSNHQTTTTPVVTTSTSSATSRDQIQTETSSLRTISPDGTTTSHASSMSSSSPNTTHLLITTSSTESTSVDTGYSTVITTHGSTLATTQVSLTPSSQNMSTVSMPSTSSQELTSLPQRQHTGNMETSSQPQNITPTVVTTSTLLSFSRGSTELQTMSWGTSSSGTINTLSTPVRNTSPASTSGILTSTLTTSGNTGYTGVTRSLGVITSRVTSTSLPGKSTVVHSTPAQPLSAHSQSHQTYGTGTPSMSQTSILPDMTSEKRVASSPGPTVTESFSHVSSSSGLTTKTDNDRNTAVSATSSTLTSPSPTTASRSTVPLPSLLPDQGISLFPYGSEVGDQNLFARTVDFNSPIFKILIGFPLGSSLRDSFYVTDNGQIIFPESDYDVFSYPNPPQRGFTGRERVAMVAPFWADADFSSSRGAIFYQEYVTFYNEHHQLIREVETLINDFTSSWGYRAKWTLKVTWVNVPAYTAQESFGTNTYQAILSTDGSRSYALFLYQNSGMRWDVTQEPYNRVLMGFSSGDGYFENSPLTFRPAMEKYRPDRFLNSKLGIRGLQVYRLHREERPNYRLKCLQWLESQPQQPSWGWSSVSCPCSWQQGQRDFRFRPINPGWWDRQLCSFSSGRGGVCCSYGAWGEFREGWRMHSPWQFDEEQEAQNWCCQWNDKPSFCVWYQLRRPRVSCAGYRPPRPAWTFGDPHITTLDNANFTFNGLGDFLLVQAQDRNSSFLLEGRTAQTGTAKATNFIAFAAQYNTSSLKSPITVQWFLEPSDKIRVVYNNQTVAFNTRDTEVLPIFNTTGVLLTQNGSQVSANFDGTVTISVIARSNILHASSSLSEEYRNHTEGLLGVWNDNPEDDFRMPNGSTIPSNSSEETLFYYGMTWHVNGTGLLGIRADPLPTKFTPIFLSQLLNQSASGEDLASGCKGDRKCMFDILATGNRTIGQSTNSILNEFQHMNDTLNQYPPSINCSSKIQAYKGQTVTTEITSNSKDATLSLSKKCSGFKLFENGSLQWTPTSPEACTLEILARDVRTNLSWVLQPKTVACFCSKEEQCLYNETSKEGNSSLEVTSCKCDGDTFGRLCERSKDPCDEPCFPNVNCIPGKGCEACPPNTTGDGRHCAALEDSCPNRSCPMNYCYNNGHCDISEAPGCQPTCTCPPAFTDNRCFLAGNSFTPTISMELPLRTIVLSLREDENASAADVNASVANILENLDMRAFFSNSLVELIRTSPGAQPSSKSIHHWKVTSHFKYRPRGPLIHYLNNQLIGAVMEAFLLQARQERQKRSGEARKDVHFFPISRADVQDQMALNLSMLEEYFTCDGYKGYHLVYSPQDGVTCVSPCSEGYCHNGGQCKHLPDGPQCSCASFTIYSSSGEHCEHLSVKLGAFYGILFGTLGALLLLGILAFMIFHFCGCSKNKFSYPLDSEL
uniprot
proteins
function
FUNCTION: Membrane-bound mucin, a family of highly glycosylated proteins that constitute the major component of the mucus, the slimy and viscous secretion covering epithelial surfaces. These glycoproteins play important roles in the protection of the epithelium and are implicated in epithelial renewal and differentiation. Regulates cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and its ability to act as an intramembrane ligand for ERBB2. Plays an important role in proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. In polarized epithelial cells, segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor. The interaction with ERBB2 leads to enhanced expression of CDKN1B. The formation of a MUC4-ERBB2-ERBB3-NRG1 complex leads to down-regulation of CDKN1B, resulting in repression of apoptosis and stimulation of proliferation. Its ability to promote tumor growth may be mainly due to repression of apoptosis as opposed to proliferation. {ECO:0000250|UniProtKB:Q99102}.
uniprot
proteins
mass_dalton
368411
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved into 2 chains, mucin-4 alpha chain and mucin-4 beta chain. {ECO:0000250|UniProtKB:Q99102}.; PTM: [Mucin-4 alpha chain]: Highly O-glycosylated. {ECO:0000250|UniProtKB:Q99102}.; PTM: [Mucin-4 beta chain]: Predominantly N-glycosylated. {ECO:0000250|UniProtKB:Q99102}.
uniprot
proteins
pubmed
12084055
uniprot
proteins
pubmed
12107190
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
3470
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Mucin-4 beta chain]: Cell membrane {ECO:0000250|UniProtKB:Q99102}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q99102}. Note=Isoforms lacking the Cys-rich region, EGF-like domains and transmembrane region are secreted. Secretion occurs by splicing or proteolytic processing. {ECO:0000250|UniProtKB:Q99102}.; SUBCELLULAR LOCATION: [Mucin-4 alpha chain]: Cell membrane {ECO:0000250|UniProtKB:Q99102}. Secreted {ECO:0000250|UniProtKB:Q99102}. Note=Forms a complex with Mucin-4 beta chain at the cell membrane. {ECO:0000250|UniProtKB:Q99102}.
uniprot
proteins
transmembrane_region
TRANSMEM 3432..3452; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins