FAM89B
entrez
23625
canonical
uniprot
Q8N5H3
canonical
ensembl
ENSG00000176973
resolver
ensp
ENSP00000314829
resolver
ensp
ENSP00000402439
resolver
ensp
ENSP00000431459
resolver
genesymbol
FAM89B
resolver
genesymbol_syn
Lrap25
resolver
hgnc
HGNC:16708
resolver
uniprot
E9PB01
resolver
uniprot
E9PL72
resolver
uniprot
Q6PJ27
resolver
uniprot_entry
LRA25_HUMAN
resolver
uniprot_sec
E9PB01
resolver
uniprot_sec
E9PL72
resolver
uniprot_sec
Q6PJ27
resolver
amino_acid_sequence
MNGLPSAEAPGGAGCALAGLPPLPRGLSGLLNASGGSWRELERVYSQRSRIHDELSRAARAPDGPRHAAGAANAGPAAGPRRPVNLDSALAALRKEMVGLRQLDMSLLCQLWGLYESIQDYKHLCQDLSFCQDLSSSLHSDSSYPPDAGLSDDEEPPDASLPPDPPPLTVPQTHNARDQWLQDAFHISL
uniprot
proteins
function
FUNCTION: Negatively regulates TGF-beta-induced signaling; in cooperation with SKI prevents the translocation of SMAD2 from the nucleus to the cytoplasm in response to TGF-beta. Acts as an adapter that mediates the specific recognition of LIMK1 by CDC42BPA and CDC42BPB in the lamellipodia. LRAP25-mediated CDC42BPA/CDC42BPB targeting to LIMK1 and the lamellipodium results in LIMK1 activation and the subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation. {ECO:0000250|UniProtKB:Q9QUI1}.
uniprot
proteins
mass_dalton
20147
uniprot
proteins
protein_family
FAM89 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
189
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000250|UniProtKB:Q9QUI1}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q9QUI1}. Note=Co-localizes with CDC42BPA, CDC42BPB and LIMK1 in the lamellipodium. {ECO:0000250|UniProtKB:Q9QUI1}.
uniprot
proteins