SH3BP4
entrez
23677
canonical
uniprot
Q9P0V3
canonical
ensembl
ENSG00000130147
resolver
ensp
ENSP00000340237
resolver
ensp
ENSP00000375867
resolver
ensp
ENSP00000386862
resolver
ensp
ENSP00000545864
resolver
ensp
ENSP00000631285
resolver
genesymbol
SH3BP4
resolver
genesymbol_syn
BOG25
resolver
genesymbol_syn
EHB10
resolver
genesymbol_syn
TTP
resolver
hgnc
HGNC:10826
resolver
uniprot
O95082
resolver
uniprot
Q309A3
resolver
uniprot
Q53QD0
resolver
uniprot
Q53TD1
resolver
uniprot_entry
SH3B4_HUMAN
resolver
uniprot_sec
O95082
resolver
uniprot_sec
Q309A3
resolver
uniprot_sec
Q53QD0
resolver
uniprot_sec
Q53TD1
resolver
amino_acid_sequence
MAAQRIRAANSNGLPRCKSEGTLIDLSEGFSETSFNDIKVPSPSALLVDNPTPFGNAKEVIAIKDYCPTNFTTLKFSKGDHLYVLDTSGGEWWYAHNTTEMGYIPSSYVQPLNYRNSTLSDSGMIDNLPDSPDEVAKELELLGGWTDDKKVPGRMYSNNPFWNGVQTNPFLNGNVPVMPSLDELNPKSTVDLLLFDAGTSSFTESSSATTNSTGNIFDELPVTNGLHAEPPVRRDNPFFRSKRSYSLSELSVLQAKSDAPTSSSFFTGLKSPAPEQFQSREDFRTAWLNHRKLARSCHDLDLLGQSPGWGQTQAVETNIVCKLDSSGGAVQLPDTSISIHVPEGHVAPGETQQISMKALLDPPLELNSDRSCSISPVLEVKLSNLEVKTSIILEMKVSAEIKNDLFSKSTVGLQCLRSDSKEGPYVSVPLNCSCGDTVQAQLHNLEPCMYVAVVAHGPSILYPSTVWDFINKKVTVGLYGPKHIHPSFKTVVTIFGHDCAPKTLLVSEVTRQAPNPAPVALQLWGKHQFVLSRPQDLKVCMFSNMTNYEVKASEQAKVVRGFQLKLGKVSRLIFPITSQNPNELSDFTLRVQVKDDQEAILTQFCVQTPQPPPKSAIKPSGQRRFLKKNEVGKIILSPFATTTKYPTFQDRPVSSLKFGKLLKTVVRQNKNHYLLEYKKGDGIALLSEERVRLRGQLWTKEWYIGYYQGRVGLVHTKNVLVVGRARPSLCSGPELSTSVLLEQILRPCKFLTYIYASVRTLLMENISSWRSFADALGYVNLPLTFFCRAELDSEPERVASVLEKLKEDCNNTENKERKSFQKELVMALLKMDCQGLVVRLIQDFVLLTTAVEVAQRWRELAEKLAKVSKQQMDAYESPHRDRNGVVDSEAMWKPAYDFLLTWSHQIGDSYRDVIQELHLGLDKMKNPITKRWKHLTGTLILVNSLDVLRAAAFSPADQDDFVI
uniprot
proteins
function
FUNCTION: May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin-mediated endocytosis. Alternatively, may act as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy. {ECO:0000269|PubMed:16325581, ECO:0000269|PubMed:22575674}.
uniprot
proteins
mass_dalton
107496
uniprot
proteins
mutagenesis
MUTAGEN 92; /note="W->A: Loss of function. Loss of targeting to the clathrin-coated pits and vesicles. Loss of interaction with DNM2, RRAGB and RRAGC. No effect on localization to the plasma membrane."; /evidence="ECO:0000269|PubMed:16325581, ECO:0000269|PubMed:22575674
uniprot
proteins
post_translational_modification
PTM: Phosphorylated upon EGF stimulation. Phosphorylation prevents interaction with DNM2. {ECO:0000269|PubMed:16325581}.
uniprot
proteins
pubmed
10644451
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616480
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16325581
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
22575674
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
30842330
uniprot
proteins
pubmed
9303539
uniprot
proteins
sequence_length
963
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane, clathrin-coated pit. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus {ECO:0000305}. Note=Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus.
uniprot
proteins