TPBG
entrez
7162
canonical
uniprot
Q13641
canonical
ensembl
ENSG00000146242
resolver
ensembl
ENSG00000283085
resolver
ensp
ENSP00000358765
resolver
ensp
ENSP00000440049
resolver
ensp
ENSP00000441219
resolver
ensp
ENSP00000489140
resolver
ensp
ENSP00000489143
resolver
ensp
ENSP00000489447
resolver
ensp
ENSP00000555101
resolver
ensp
ENSP00000555102
resolver
ensp
ENSP00000555103
resolver
ensp
ENSP00000601001
resolver
ensp
ENSP00000601002
resolver
enst
ENST00000369750
resolver
enst
ENST00000535040
resolver
enst
ENST00000543496
resolver
enst
ENST00000634817
resolver
enst
ENST00000634826
resolver
enst
ENST00000635036
resolver
enst
ENST00000885042
resolver
enst
ENST00000885043
resolver
enst
ENST00000885044
resolver
enst
ENST00000930942
resolver
enst
ENST00000930943
resolver
genesymbol
TPBG
resolver
genesymbol_syn
5T4
resolver
hgnc
HGNC:12004
resolver
uniprot
A8K555
resolver
uniprot_entry
TPBG_HUMAN
resolver
uniprot_sec
A8K555
resolver
amino_acid_sequence
MPGGCSRGPAAGDGRLRLARLALVLLGWVSSSSPTSSASSFSSSAPFLASAVSAQPPLPDQCPALCECSEAARTVKCVNRNLTEVPTDLPAYVRNLFLTGNQLAVLPAGAFARRPPLAELAALNLSGSRLDEVRAGAFEHLPSLRQLDLSHNPLADLSPFAFSGSNASVSAPSPLVELILNHIVPPEDERQNRSFEGMVVAALLAGRALQGLRRLELASNHFLYLPRDVLAQLPSLRHLDLSNNSLVSLTYVSFRNLTHLESLHLEDNALKVLHNGTLAELQGLPHIRVFLDNNPWVCDCHMADMVTWLKETEVVQGKDRLTCAYPEKMRNRVLLELNSADLDCDPILPPSLQTSYVFLGIVLALIGAIFLLVLYLNRKGIKKWMHNIRDACRDHMEGYHYRYEINADPRLTNLSSNSDV
uniprot
proteins
function
FUNCTION: May function as an inhibitor of Wnt/beta-catenin signaling by indirectly interacting with LRP6 and blocking Wnt3a-dependent LRP6 internalization. {ECO:0000269|PubMed:22100263}.
uniprot
proteins
mass_dalton
46032
uniprot
proteins
mutagenesis
MUTAGEN 76; /note="K->A: Strongly reduces Wnt inhibitory function."; /evidence="ECO:0000269|PubMed:24582434"; MUTAGEN 97; /note="F->T: Strongly reduces Wnt inhibitory function."; /evidence="ECO:0000269|PubMed:24582434"; MUTAGEN 124; /note="N->Q: Impaired trafficking to the cell surface."; /evidence="ECO:0000269|PubMed:24582434"; MUTAGEN 214; /note="R->E: Impaired trafficking to the cell surface."; /evidence="ECO:0000269|PubMed:24582434"; MUTAGEN 325; /note="Y->A: Reduces Wnt inhibitory function."; /evidence="ECO:0000269|PubMed:24582434
uniprot
proteins
post_translational_modification
PTM: Highly glycosylated. {ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:24582434}.
uniprot
proteins
pubmed
12481437
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
22100263
uniprot
proteins
pubmed
24582434
uniprot
proteins
pubmed
8132670
uniprot
proteins
sequence_length
420
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24582434}; Single-pass type I membrane protein {ECO:0000269|PubMed:24582434}.
uniprot
proteins
transmembrane_region
TRANSMEM 356..376; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins