Aff4
entrez
93736
canonical
uniprot
Q9ESC8
canonical
ensembl
ENSMUSG00000049470
resolver
ensp
ENSMUSP00000051479
resolver
ensp
ENSMUSP00000289759
resolver
ensp
ENSMUSP00000289761
resolver
enst
ENSMUST00000060945
resolver
genesymbol
Aff4
resolver
genesymbol_syn
Alf4
resolver
uniprot
B2RST9
resolver
uniprot
B7ZNX0
resolver
uniprot
Q8C6K4
resolver
uniprot
Q8C6W3
resolver
uniprot
Q8CCH3
resolver
uniprot_entry
AFF4_MOUSE
resolver
uniprot_entry
B7ZNX0_MOUSE
resolver
uniprot_sec
B2RST9
resolver
uniprot_sec
Q8C6K4
resolver
uniprot_sec
Q8C6W3
resolver
uniprot_sec
Q8CCH3
resolver
amino_acid_sequence
MNREDRNVLRMKERERRNQEIQQGEDAFPPSSPLFAEPYKVTSKEDKLSSRIQSMLGNYDEMKDYIGDRSIPKLVAIPKPAVPTTTDEKANPNFFEQRHGGSHQSSKWTPVGPAPSTSQSQKRSSALQSGHSSQRSGAGGSGASSSGQRHDRDSYSSSRKKGQHGSEHSKSRSSSPGKPQAVSSLSSSHSRSHGNDHHSKEHQRSKSPRDPDANWDSPSRGPFSSGQHSSQSFPPSLMSKSSSMLQKPTAYVRPMDGQESVEPKLSSEHYSSQSHGNSMTELKPSSKAHLTKLKIPSRPLDASVSGDVSCVDEILKEMTHSWPPPLTAIHTPCKTEPSKFPFPTKESQQSNFGPGEQKRYSTAKTSNGHQSKSMLKDDLKLSSSEDSDGEQDCDKTMPRSTPGSNSEPSHHNSEGADNSRDDSSSHSGSESSSGSDSESESSSSDSEANEPSQSASPEPEPPPTNKWQLDNWLNKVNPHKVSPASSVDSNIPSSQAYKKEGREQGTASNYTDPGGTKETSSATPGRDSKTIQKGSESGRGRQKSPAQSDSTTQRRTVGKKQPKKPEKSAAEEPRGGLKIESETPVDMAASMPSSRHKAATKGSRKPNIKKESKSSPRPTAEKKKYKSASKPSQKSREIIETDTSSSDSDGSESLPPSSQTPKYPESNRTPVKPSSVEEEDSFFRQRMFSPMEEKELLSPLSEPDDRYPLIVKIDLNLLTRIPGKPYKETEPPKGEKKNVPEKHSREVQKQASEKASNKGKRKHKNDDDTRASESKKPKTEDKNSSGHKPSSSRESSKQSSTKEKDLLPSPAGPILSKDSKTEHGSRKRTVSQSSSLKSSGTSSKENSGSSSKSSSSSTAKQKKTEGKGPSSSKEAKEKAPNSSSNCPPSTPTSESSKPRRTKLAFDDRNYSADHYLQEAKKLKHNADALSDRFEKAVYYLDAVVSFIECGNALEKNAQESKSPFPMYSDTVELIKYTMKLKNYLAPDATAADKRLTVLCLRCQSLLYLRLFKLKKENALKYSKTLTEHLKNSYSNSQAPSPGLGSKAVGMPSPVSPKLSPGNSGSYSSGGSSASASGSSVTIPQKIHQMAASYVQVTSNFLYATEIWDQAEQLSKEQKEFFAELDKVMGPLIFNASIMTDLARYTRQGLHWLRQDAKLIS
uniprot
proteins
function
FUNCTION: Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. {ECO:0000250|UniProtKB:Q9UHB7}.
uniprot
proteins
mass_dalton
126639
uniprot
proteins
post_translational_modification
PTM: Dephosphorylated at Ser-544 by the PNUTS-PP1 complex, promoting RNA polymerase II transcription pause-release. {ECO:0000250|UniProtKB:Q9UHB7}.
uniprot
proteins
protein_family
AF4 family
uniprot
proteins
pubmed
10704283
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16024815
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22195968
uniprot
proteins
pubmed
23273992
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
1160
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22195968}. Chromosome {ECO:0000269|PubMed:22195968}. Note=Associates to transcriptionally active chromatin but not at snRNA genes. {ECO:0000269|PubMed:22195968}.
uniprot
proteins