Cmklr1
entrez
60669
canonical
uniprot
O35786
canonical
ensembl
ENSRNOG00000000704
resolver
ensembl
ENSRNOG00055002284
resolver
ensembl
ENSRNOG00060007338
resolver
ensembl
ENSRNOG00065007172
resolver
ensp
ENSRNOP00000000893
resolver
ensp
ENSRNOP00000085339
resolver
ensp
ENSRNOP00000089521
resolver
ensp
ENSRNOP00000091942
resolver
ensp
ENSRNOP00000101709
resolver
ensp
ENSRNOP00000102773
resolver
ensp
ENSRNOP00000104307
resolver
ensp
ENSRNOP00000105541
resolver
ensp
ENSRNOP00000109591
resolver
ensp
ENSRNOP00000110285
resolver
ensp
ENSRNOP00055002731
resolver
ensp
ENSRNOP00055002732
resolver
ensp
ENSRNOP00055002733
resolver
ensp
ENSRNOP00055002734
resolver
ensp
ENSRNOP00060009096
resolver
ensp
ENSRNOP00060009099
resolver
ensp
ENSRNOP00060009106
resolver
ensp
ENSRNOP00060009107
resolver
ensp
ENSRNOP00065008149
resolver
ensp
ENSRNOP00065008150
resolver
ensp
ENSRNOP00065008151
resolver
ensp
ENSRNOP00065008155
resolver
enst
ENSRNOT00000000893
resolver
enst
ENSRNOT00000097365
resolver
enst
ENSRNOT00000101222
resolver
enst
ENSRNOT00000105285
resolver
enst
ENSRNOT00000124979
resolver
enst
ENSRNOT00000137411
resolver
enst
ENSRNOT00000141769
resolver
enst
ENSRNOT00000158605
resolver
enst
ENSRNOT00000165927
resolver
enst
ENSRNOT00000166562
resolver
enst
ENSRNOT00055003634
resolver
enst
ENSRNOT00055003635
resolver
enst
ENSRNOT00055003638
resolver
enst
ENSRNOT00055003639
resolver
enst
ENSRNOT00060012066
resolver
enst
ENSRNOT00060012070
resolver
enst
ENSRNOT00060012076
resolver
enst
ENSRNOT00060012078
resolver
enst
ENSRNOT00065011157
resolver
enst
ENSRNOT00065011159
resolver
enst
ENSRNOT00065011161
resolver
enst
ENSRNOT00065011166
resolver
genesymbol
Cmklr1
resolver
genesymbol_syn
Dez
resolver
uniprot
G3V625
resolver
uniprot_entry
CML1_RAT
resolver
uniprot_sec
G3V625
resolver
amino_acid_sequence
MEYEGYNDSSIYGEEYSDGSDYIVDLEEAGPLEAKVAEVFLVVIYSLVCFLGILGNGLVIVIATFKMKKTVNTVWFVNLAVADFLFNIFLPIHITYAAMDYHWVFGKAMCKISSFLLSHNMYTSVFLLTVISFDRCISVLLPVWSQNHRSVRLAYMTCVVVWVLAFFLSSPSLVFRDTVSTSHGKITCFNNFSLAAPEPFSHSTHPRTDPVGYSRHVAVTVTRFLCGFLIPVFIITACYLTIVFKLQRNRLAKTKKPFKIIITIIITFFLCWCPYHTLYLLELHHTAVPASVFSLGLPLATAVAIANSCMNPILYVFMGHDFKKFKVALFSRLVNALSEDTGPSSYPSHRSFTKMSSLIEKASVNEKETSTL
uniprot
proteins
function
FUNCTION: Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2), TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like, reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism (By similarity). {ECO:0000250|UniProtKB:Q99788}.
uniprot
proteins
mass_dalton
41865
uniprot
proteins
protein_family
Chemokine-like receptor (CMKLR) family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9425281
uniprot
proteins
sequence_length
372
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q99788}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..62; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 74..95; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 113..133; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 153..174; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 224..244; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 261..281; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 300..319; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins