TFCP2
entrez
7024
canonical
uniprot
Q12800
canonical
ensembl
ENSG00000135457
resolver
ensp
ENSP00000257915
resolver
ensp
ENSP00000447991
resolver
ensp
ENSP00000573799
resolver
genesymbol
TFCP2
resolver
genesymbol_syn
LSF
resolver
genesymbol_syn
SEF
resolver
hgnc
HGNC:11748
resolver
uniprot
A8K5E9
resolver
uniprot
Q12801
resolver
uniprot
Q9UD75
resolver
uniprot
Q9UD77
resolver
uniprot_entry
TFCP2_HUMAN
resolver
uniprot_sec
A8K5E9
resolver
uniprot_sec
Q12801
resolver
uniprot_sec
Q9UD75
resolver
uniprot_sec
Q9UD77
resolver
amino_acid_sequence
MAWALKLPLADEVIESGLVQDFDASLSGIGQELGAGAYSMSDVLALPIFKQEESSLPPDNENKILPFQYVLCAATSPAVKLHDETLTYLNQGQSYEIRMLDNRKLGELPEINGKLVKSIFRVVFHDRRLQYTEHQQLEGWRWNRPGDRILDIDIPMSVGIIDPRANPTQLNTVEFLWDPAKRTSVFIQVHCISTEFTMRKHGGEKGVPFRVQIDTFKENENGEYTEHLHSASCQIKVFKPKGADRKQKTDREKMEKRTPHEKEKYQPSYETTILTECSPWPEITYVNNSPSPGFNSSHSSFSLGEGNGSPNHQPEPPPPVTDNLLPTTTPQEAQQWLHRNRFSTFTRLFTNFSGADLLKLTRDDVIQICGPADGIRLFNALKGRMVRPRLTIYVCQESLQLREQQQQQQQQQQKHEDGDSNGTFFVYHAIYLEELTAVELTEKIAQLFSISPCQISQIYKQGPTGIHVLISDEMIQNFQEEACFILDTMKAETNDSYHIILK
uniprot
proteins
function
FUNCTION: Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter. {ECO:0000250, ECO:0000269|PubMed:10455131, ECO:0000269|PubMed:1732747, ECO:0000269|PubMed:8035790, ECO:0000269|PubMed:8157699}.
uniprot
proteins
mass_dalton
57256
uniprot
proteins
mutagenesis
MUTAGEN 211; /note="V->E: Does not affect DNA-binding activity."; /evidence="ECO:0000269|PubMed:8035790"; MUTAGEN 213; /note="I->R: Does not affect DNA-binding activity."; /evidence="ECO:0000269|PubMed:8035790"; MUTAGEN 234; /note="Q->L: Significant reduction of DNA-binding activity."; /evidence="ECO:0000269|PubMed:8035790"; MUTAGEN 236; /note="K->E: Significant reduction of DNA-binding activity."; /evidence="ECO:0000269|PubMed:8035790
uniprot
proteins
protein_family
CP2 subfamily
uniprot
proteins
protein_family
Grh/CP2 family
uniprot
proteins
pubmed
10455131
uniprot
proteins
pubmed
11003662
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1732747
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
7828600
uniprot
proteins
pubmed
8035790
uniprot
proteins
pubmed
8114710
uniprot
proteins
pubmed
8157699
uniprot
proteins
sequence_length
502
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:1732747, ECO:0000269|PubMed:7828600, ECO:0000269|PubMed:8114710}.
uniprot
proteins