Csnk1a1
entrez
113927
canonical
uniprot
P97633
canonical
ensembl
ENSRNOG00000072163
resolver
ensp
ENSRNOP00000101687
resolver
ensp
ENSRNOP00000104017
resolver
enst
ENSRNOT00000148420
resolver
enst
ENSRNOT00000167200
resolver
genesymbol
Csnk1a1
resolver
uniprot
A0ABK0L909
resolver
uniprot
A0ABK0LI34
resolver
uniprot
A0JPL2
resolver
uniprot
P97634
resolver
uniprot_entry
A0ABK0L909_RAT
resolver
uniprot_entry
A0ABK0LI34_RAT
resolver
uniprot_entry
A0JPL2_RAT
resolver
uniprot_entry
KC1A_RAT
resolver
uniprot_sec
P97634
resolver
amino_acid_sequence
MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQGKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGF
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (By similarity). Phosphorylates a large number of proteins (By similarity). Participates in Wnt signaling (PubMed:11955436). Phosphorylates CTNNB1 at 'Ser-45' (By similarity). May phosphorylate PER1 and PER2 (By similarity). May play a role in segregating chromosomes during mitosis (By similarity). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (By similarity). Acts as a positive regulator of mTORC1 and mTORC2 signaling in response to nutrients by mediating phosphorylation of DEPTOR inhibitor (By similarity). Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). {ECO:0000250|UniProtKB:P48729, ECO:0000250|UniProtKB:Q8BK63, ECO:0000269|PubMed:11955436}.
uniprot
proteins
mass_dalton
37495
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MTOR in response to mitogenic stimulation, leading to its activation (By similarity). Recognized by CRBN and is targeted for degradation by DCX (DDB1-CUL4-X-box) E3 protein ligase complex (By similarity). {ECO:0000250|UniProtKB:P48729}.
uniprot
proteins
protein_family
CK1 Ser/Thr protein kinase family
uniprot
proteins
protein_family
Casein kinase I subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11955436
uniprot
proteins
pubmed
8973207
uniprot
proteins
sequence_length
325
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P48729}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P48729}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:P48729}. Nucleus speckle {ECO:0000250|UniProtKB:P48729}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8BK63}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q8BK63}. Note=Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. Also recruited to the keratin cytoskeleton. {ECO:0000250|UniProtKB:P48729}.
uniprot
proteins