Ngf
entrez
310738
canonical
uniprot
P25427
canonical
ensembl
ENSRNOG00000016571
resolver
ensembl
ENSRNOG00055019867
resolver
ensembl
ENSRNOG00060030051
resolver
ensembl
ENSRNOG00065030707
resolver
ensp
ENSRNOP00000022200
resolver
ensp
ENSRNOP00000089587
resolver
ensp
ENSRNOP00000097792
resolver
ensp
ENSRNOP00000100726
resolver
ensp
ENSRNOP00055027588
resolver
ensp
ENSRNOP00055027600
resolver
ensp
ENSRNOP00060043457
resolver
ensp
ENSRNOP00060043488
resolver
ensp
ENSRNOP00065043459
resolver
ensp
ENSRNOP00065043468
resolver
enst
ENSRNOT00000022200
resolver
enst
ENSRNOT00000097020
resolver
enst
ENSRNOT00000116899
resolver
enst
ENSRNOT00000153271
resolver
enst
ENSRNOT00055033970
resolver
enst
ENSRNOT00055033983
resolver
enst
ENSRNOT00060052234
resolver
enst
ENSRNOT00060052266
resolver
enst
ENSRNOT00065052921
resolver
enst
ENSRNOT00065052933
resolver
genesymbol
Ngf
resolver
genesymbol_syn
Ngfb
resolver
uniprot
A0A0G2K2Z7
resolver
uniprot_entry
A0A0G2K2Z7_RAT
resolver
uniprot_entry
NGF_RAT
resolver
amino_acid_sequence
MSMLFYTLITAFLIGVQAEPYTDSNVPEGDSVPEAHWTKLQHSLDTALRRARSAPAEPIAARVTGQTRNITVDPKLFKKRRLRSPRVLFSTQPPPTSSDTLDLDFQAHGTISFNRTHRSKRSSTHPVFHMGEFSVCDSVSVWVGDKTTATDIKGKEVTVLGEVNINNSVFKQYFFETKCRAPNPVESGCRGIDSKHWNSYCTTTHTFVKALTTDDKQAAWRFIRIDTACVCVLSRKAARRG
uniprot
proteins
function
FUNCTION: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (By similarity). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity). {ECO:0000250|UniProtKB:P01138, ECO:0000250|UniProtKB:P01139}.
uniprot
proteins
mass_dalton
27010
uniprot
proteins
protein_family
NGF-beta family
uniprot
proteins
pubmed
2025430
uniprot
proteins
pubmed
3184206
uniprot
proteins
sequence_length
241
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01138}. Endosome lumen {ECO:0000250|UniProtKB:P01139}. Note=ProNGF is endocytosed after binding to the cell surface receptor formed by SORT1 and NGFR. {ECO:0000250|UniProtKB:P01139}.
uniprot
proteins