Lpxn
entrez
107321
canonical
uniprot
Q99N69
canonical
ensembl
ENSMUSG00000024696
resolver
ensp
ENSMUSP00000025601
resolver
ensp
ENSMUSP00000157548
resolver
enst
ENSMUST00000025601
resolver
enst
ENSMUST00000235690
resolver
genesymbol
Lpxn
resolver
uniprot
A0A494B990
resolver
uniprot_entry
A0A494B990_MOUSE
resolver
uniprot_entry
LPXN_MOUSE
resolver
amino_acid_sequence
MEELDALLEELERCTFQDSEEYSNPVSCHLDQQSTEESKIPQTPKTLSSQGNTSPLKVQLVYATNIQEPNVYSEVQEPKESVLPPKTSAAAQLDELMAHLSEMQAKVSVKADTSRKPLPDQQDHKASLDSMLGDLEQELQDLGIATVPKGYCASCQKPIAGKVIHALGQSWHPEHFVCTHCKEELGSSPFFERSGLAYCSKDYHRLFSPRCAYCAAPITDKVLTAMNKTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFSPKCGGCNRPVLENYLSAMNTVWHPECFVCGDCFSSFSSGSFFELDGRPFCELHYHHRRGTLCHDCGQPITGRCISAMGHKFHPEHFVCAFCLTQLPKGIFKEQNNKTYCEKCFTKLFSQ
uniprot
proteins
function
FUNCTION: Transcriptional coactivator for androgen receptor (AR) and serum response factor (SRF). Contributes to the regulation of cell adhesion, spreading and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events. Suppresses the integrin-induced tyrosine phosphorylation of paxillin (PXN). May play a critical role as an adapter protein in the formation of the adhesion zone in osteoclasts. Negatively regulates B-cell antigen receptor (BCR) signaling. {ECO:0000269|PubMed:12674328, ECO:0000269|PubMed:17640867, ECO:0000269|PubMed:18497331, ECO:0000269|PubMed:19917054}.
uniprot
proteins
mass_dalton
43478
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues. Phosphorylation on Tyr-72 is important for its inhibitory function. Bombesin stimulates phosphorylation on Tyr-22, Tyr-62 and Tyr-72 (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Paxillin family
uniprot
proteins
pubmed
12674328
uniprot
proteins
pubmed
15786712
uniprot
proteins
pubmed
17640867
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
18497331
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19917054
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
386
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell junction, focal adhesion. Nucleus. Cytoplasm, perinuclear region. Cell projection, podosome. Cell membrane. Note=Shuttles between the cytoplasm and nucleus. Recruited to the cell membrane following B-cell antigen receptor (BCR) cross-linking in B-cells. Enhanced focal adhesion kinase activity (PTK2/FAK) attenuates its nuclear accumulation and limits its ability to enhance serum response factor (SRF)-dependent gene transcription. Targeting to focal adhesions is essential for its tyrosine phosphorylation in response to bombesin (By similarity). {ECO:0000250}.
uniprot
proteins