Odc1
entrez
24609
canonical
uniprot
P09057
canonical
ensembl
ENSRNOG00000005424
resolver
ensembl
ENSRNOG00055005635
resolver
ensembl
ENSRNOG00060003971
resolver
ensembl
ENSRNOG00065005649
resolver
ensp
ENSRNOP00000007259
resolver
ensp
ENSRNOP00055006903
resolver
ensp
ENSRNOP00060004964
resolver
ensp
ENSRNOP00065005927
resolver
enst
ENSRNOT00000007259
resolver
enst
ENSRNOT00055009060
resolver
enst
ENSRNOT00060006624
resolver
enst
ENSRNOT00065008423
resolver
genesymbol
Odc1
resolver
genesymbol_syn
Odc
resolver
uniprot_entry
DCOR_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by antizymes (AZs) OAZ1, OAZ2 and OAZ3 in response to polyamine levels. AZs inhibit the assembly of the functional homodimer by binding to ODC monomers. Additionally, OAZ1 targets ODC monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. {ECO:0000250|UniProtKB:P11926}.
uniprot
proteins
amino_acid_sequence
MGSFTKEEFDCHILDEGFTAKDILDQKINEVSSSDDKDAFYVADLGDVLKKHLRWLKALPRVTPFYAVKCNDSRAIVSTLAAIGTGFDCASKTEIQLVQGLGVPPERIIYANPCKQVSQIKYAASNGVQMMTFDSEIELMKVARAHPKAKLVLRIATDDSKAVCRLSVKFGATLKTSRLLLERAKELNIDVIGVSFHVGSGCTDPETFVQAVSDARCVFDMGTEVGFSMYLLDIGGGFPGSEDTKLKFEEITSVINPALDKYFPSDSGVRIIAEPGRYYVASAFTLAVNIIAKKTVWKEQTGSDDEDESNEQTLMYYVNDGVYGSFNCILYDHAHVKALLQKRPKPDEKYYSSSIWGPTCDGLDRIVERCSLPEMHVGDWMLFENMGAYTVAAASTFNGFQRPNIYYVMSRSMWQLMKQIQSHGFPPEVEEQDVGTLPMSCAQESGMDRHPAACASASINV
uniprot
proteins
ec_number
4.1.1.17
uniprot
proteins
function
FUNCTION: Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. {ECO:0000250|UniProtKB:P11926}.
uniprot
proteins
mass_dalton
51047
uniprot
proteins
pathway_participation
PATHWAY: Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.
uniprot
proteins
protein_family
Orn/Lys/Arg decarboxylase class-II family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2006916
uniprot
proteins
pubmed
2722815
uniprot
proteins
pubmed
3419906
uniprot
proteins
pubmed
3443298
uniprot
proteins
sequence_length
461
uniprot
proteins