Mepe
entrez
94111
canonical
uniprot
Q8K4L6
canonical
ensembl
ENSMUSG00000053863
resolver
ensp
ENSMUSP00000065200
resolver
enst
ENSMUST00000066207
resolver
genesymbol
Mepe
resolver
uniprot
D6C6N6
resolver
uniprot
Q3TYZ5
resolver
uniprot
Q924I1
resolver
uniprot_entry
MEPE_MOUSE
resolver
uniprot_sec
D6C6N6
resolver
uniprot_sec
Q3TYZ5
resolver
uniprot_sec
Q924I1
resolver
amino_acid_sequence
MTPEGLMKMQAVSVGLLLFSMTWAAPMPNEDRSSCGNQDSIHKDLAASVYPDPTVDEGTEDGQGALLHPPGQDRYGAALLRNITQPVKSLVTGAELRREGNQEKRPQSVLSVIPADVNDAKVSLKDIKNQESYLLTQSSPVKSKHTKHTRQTRRSTHYLTHLPQIKKTPSDLEGSGSPDLLVRGDNDVPPFSGDGQHFMHIPGKGGAGSGPESSTSRPLSGSSKAEVIDPHMSGLGSNEIPGREGHGGSAYATRDKAAQGAGSAGGSLVGGSNEITGSTNFRELPGKEGNRINAGSQNAHQGKVEFHYPQVASREKVKGGVEHAGRAGYNEIPKSSKGSSSKDAEESKGNQLTLTASQRFPGKGKSQGPALPSHSLSNEVKSEENHYVFHGQNNLTPNKGMSQRRGSWPSRRPNSHRRASTRQRDSSESSSSGSSSESHGD
uniprot
proteins
function
FUNCTION: Regulates renal phosphate and uric acid excretion (PubMed:26051469). Regulates bone mineralization by osteoblasts and cartilage mineralization by chondrocytes (PubMed:11414762, PubMed:12421822, PubMed:15843468, PubMed:22766095). Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage (PubMed:26927967). Increases dental pulp stem cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q9NQ76, ECO:0000269|PubMed:11414762, ECO:0000269|PubMed:12421822, ECO:0000269|PubMed:15843468, ECO:0000269|PubMed:22766095, ECO:0000269|PubMed:26051469, ECO:0000269|PubMed:26927967}.
uniprot
proteins
mass_dalton
46872
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine residues in the ASARM motif; the phosphorylation is important for the inhibition of bone mineralization. {ECO:0000269|PubMed:15843468, ECO:0000269|PubMed:18597632, ECO:0000269|PubMed:22766095}.; PTM: Cleaved by CTSB/cathepsin B; the cleavage is blocked by metalloprotease PHEX. {ECO:0000250|UniProtKB:Q9NQ76}.
uniprot
proteins
protein_family
PF07175/osteoregulin family
uniprot
proteins
pubmed
11414762
uniprot
proteins
pubmed
12421822
uniprot
proteins
pubmed
15221418
uniprot
proteins
pubmed
15329369
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15843468
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18597632
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19924383
uniprot
proteins
pubmed
22042093
uniprot
proteins
pubmed
22766095
uniprot
proteins
pubmed
26051469
uniprot
proteins
pubmed
26428891
uniprot
proteins
pubmed
26927967
uniprot
proteins
sequence_length
441
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:12421822, ECO:0000269|PubMed:18597632, ECO:0000269|PubMed:26051469}. Secreted {ECO:0000250|UniProtKB:Q9NQ76}.
uniprot
proteins