Prmt3
entrez
71974
canonical
uniprot
Q922H1
canonical
ensembl
ENSMUSG00000030505
resolver
ensp
ENSMUSP00000032715
resolver
enst
ENSMUST00000032715
resolver
genesymbol
Prmt3
resolver
genesymbol_syn
Hrmt1l3
resolver
uniprot
Q3U2K1
resolver
uniprot
Q80VU9
resolver
uniprot
Q8BFV5
resolver
uniprot_entry
ANM3_MOUSE
resolver
uniprot_sec
Q3U2K1
resolver
uniprot_sec
Q80VU9
resolver
uniprot_sec
Q8BFV5
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by N-ethylmaleimide and high concentrations of zinc chloride. {ECO:0000250|UniProtKB:O70467}.
uniprot
proteins
amino_acid_sequence
MCSLAAGNGRGAELGPEPLELSDSGDDAGWEDEDADTEPAHGRQHTPCLFCDRLFASAEETFSHCKLEHQFNIDSMVHKHGLEFYGYIKLINFIRLKNPTVEYMNSIYNPVPWEKDEYLKPVLEDDLLLQFDVEDLYEPVSTPFSYPNGLSESASVVEKLKHMEARALSAEAALARAREDLQKMKQFAQDFVMNVDVRTCSSTTTIADLQEDEDGVYFSSYGHYGIHEEMLKDKVRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKVGAKKVIAVDQSEILYQAMDIIRLNKLEDTIVLIKGKIEEVSLPVEKVDVIISEWMGYFLLFESMLDSVLYAKSKYLAKGGSVYPDICTISLVAVSDVSKHADRIAFWDDVYGFNMSCMKKAVIPEAVVEVVDHKTLISDPCDIKHIDCHTTSISDLEFSSDFTLRTTKTAMCTAVAGYFDIYFEKNCHNRVVFSTGPQSTKTHWKQTVFLLEKPFPVKAGEALKGKITVHKNKKDPRSLIVTLTLNSSTQTYSLQ
uniprot
proteins
ec_number
2.1.1.319
uniprot
proteins
function
FUNCTION: Protein-arginine N-methyltransferase that catalyzes both the monomethylation and asymmetric dimethylation of the guanidino nitrogens of arginine residues in target proteins, and therefore falls into the group of type I methyltransferases (By similarity). Catalyzes the asymmetric arginine dimethylation at multiple sites in the Arg/Gly-rich region of small ribosomal subunit protein uS5/RPS2 (PubMed:15473865, PubMed:17439947). Also appears to methylate other ribosomal proteins (PubMed:15473865). May regulate retinoic acid synthesis and signaling by inhibiting ALDH1A1 retinal dehydrogenase activity (By similarity). Contributes to methylation of histone H4 'Arg-3', a specific tag for epigenetic transcriptional activation (By similarity). Promotes osteogenesis (PubMed:31378783). {ECO:0000250|UniProtKB:O60678, ECO:0000269|PubMed:15473865, ECO:0000269|PubMed:17439947, ECO:0000269|PubMed:31378783}.
uniprot
proteins
mass_dalton
59471
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
Protein arginine N-methyltransferase family
uniprot
proteins
pubmed
15473865
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17439947
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31378783
uniprot
proteins
sequence_length
528
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000305|PubMed:15473865}. Nucleus {ECO:0000250|UniProtKB:O60678}.
uniprot
proteins