Tm7sf3
entrez
297725
canonical
uniprot
Q5FVF4
canonical
ensembl
ENSRNOG00000001817
resolver
ensp
ENSRNOP00000002486
resolver
enst
ENSRNOT00000002486
resolver
genesymbol
Tm7sf3
resolver
uniprot_entry
TM7S3_RAT
resolver
amino_acid_sequence
MWRLRLLVLAVLAAGSAEAQANSSDGFLEFSVGKFTYFVLSRRFPQEAVLRHISSNVTFLLFQIHSQYQNTTVSYTKTLLPSTSGTGNDRGLVFILRPEQTVCTWYLETEDTKPVQSVAVTLSYSERDPIPGGCNLEFDLDIDPNIYLDYNFFETTIKFAPANIGYARAAEPPPCDVSTGQESRWRLRYHVYQYFLPEGDLTEASLLQHLQRMAQVVQVMASAVKVVTLTADDKTVVSFSSLPGQGVIYNVIVWDPSLNTSAAYVPVHTYACSFDSVDGNCVPPGRVSTKVFSTLFALLGLFTCFFGHRFWKTELFFVGFIFLGFFFYILITRLTALKYEVRLVLTAVAGSIGGLLLVASWWRFGILTLCMLCVGLVLGFLVSSGTFFTPLGNLNVFHDDGVFWVTFSCIALLVPVIFLGCLRILNILACGIVGSYSVVLAINSYMFTSLSYITLNVLRRALNADFRGAFIRVPFQTNDYIILAVWGMLAVTGITLQIRRERGRPPFPPHPYKLWKQERERRVTNILDPSHHIPPLRERLYGWVARIKELFQKEQPAGERTPLLL
uniprot
proteins
function
FUNCTION: Involved in the inhibition of cytokine-induced death of pancreatic beta cells (By similarity). Involved in the promotion of insulin secretion from pancreatic beta cells (By similarity). Is a downstream transcriptional target of p53/TP53, and acts as a pro-survival homeostatic factor that attenuates the development of cellular stress. Maintains protein homeostasis and promotes cell survival through attenuation of endoplasmic reticulum (ER) stress and the subsequent induction of unfolded protein response (UPR) (By similarity). {ECO:0000250|UniProtKB:Q9CRG1, ECO:0000250|UniProtKB:Q9NS93}.
uniprot
proteins
mass_dalton
63585
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
565
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9NS93}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 287..307; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 311..331; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 341..361; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 364..384; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 402..422; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 427..447; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 478..498; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins