Nkrf
entrez
77286
canonical
uniprot
Q8BY02
canonical
ensembl
ENSMUSG00000044149
resolver
ensp
ENSMUSP00000061546
resolver
ensp
ENSMUSP00000159216
resolver
enst
ENSMUST00000057093
resolver
enst
ENSMUST00000239259
resolver
genesymbol
Nkrf
resolver
genesymbol_syn
Nrf
resolver
uniprot
A0A668KL68
resolver
uniprot
A2A3V7
resolver
uniprot
Q8BJU5
resolver
uniprot
Q9CRL2
resolver
uniprot_entry
A0A668KL68_MOUSE
resolver
uniprot_entry
NKRF_MOUSE
resolver
uniprot_sec
A2A3V7
resolver
uniprot_sec
Q8BJU5
resolver
uniprot_sec
Q9CRL2
resolver
amino_acid_sequence
MEKILHMAEGIDIGEMPSYDLMLPKPSKGQKRYLSTYDGQNPPKKQAGSKFHVRARFEPVHFVASSSKAERQEDPYGPQTKDVNGRTHFASMPRNFYQDYTQDSFSIQDGNSQYCNSSGFIFTKDQPVATNMYFDSGNPAPSSTSQQANCQPAPEPPPSQMYPESLVAEKQYFIEKLTATIWKNLSNPEMTSGSDKINYTYMLTRCIQACKTNPEYIYAPLKEIPPADIPKNKKLLTDGYACEVRCQNIYLTTGYAGSKNGSRDRATELAVKLLQKRIEVRVVRRKFKHIIGEDLVVCQIGMLSYEFPPALKPPEDLVVLGKDASGQPIFNSSAKHWTNFVITENANDAIGILNNSASFNKMSIEYKYEMMPNRTWRCRVFLQDHCLAEGYGTKKTSKHAAADEALKVLQKTQPTYPSVKSSQCHSGSSPKGSGKKKDIKDLVVYENSSNPVCTLNDTAQFNRMTVEYVYERMTGLRWKCKVILESEVIAEAVGVKKSVKYEAAGEAVKTLKKTQPTVINNLKKGTVEDVISRNEIQGRSAEEAYKQQIKEDNIGNQLLRKMGWTGGGLGKSGEGIREPISVKEQHKREGLGLDVERVNKIAKRDIEQIIRNYARSESHSDLTFSTELTNDERKQIHQIAQKYGLKSKSHGVGHDRYLVVGRKRRKEDLLDQLKQEGQVGHYELVMPQAN
uniprot
proteins
function
FUNCTION: Enhances the ATPase activity of DHX15 by acting like a brace that tethers mobile sections of DHX15 together, stabilizing a functional conformation with high RNA affinity of DHX15. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription. May also act as a DNA-binding transcription regulator: interacts with a specific negative regulatory element (NRE) 5'-AATTCCTCTGA-3' to mediate transcriptional repression of certain NK-kappa-B responsive genes. {ECO:0000250|UniProtKB:O15226}.
uniprot
proteins
mass_dalton
77739
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
690
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:O15226}.
uniprot
proteins