Ryk
entrez
20187
canonical
uniprot
Q01887
canonical
ensembl
ENSMUSG00000032547
resolver
ensp
ENSMUSP00000035142
resolver
ensp
ENSMUSP00000135858
resolver
enst
ENSMUST00000035142
resolver
enst
ENSMUST00000175883
resolver
genesymbol
Ryk
resolver
genesymbol_syn
Mrk
resolver
uniprot
H9H9R6
resolver
uniprot
Q61890
resolver
uniprot
Q8K272
resolver
uniprot_entry
H9H9R6_MOUSE
resolver
uniprot_entry
Q8K272_MOUSE
resolver
uniprot_entry
RYK_MOUSE
resolver
uniprot_sec
Q61890
resolver
amino_acid_sequence
MRAGRGGVPGSGGLRAPPPPLLLLLLAMLPAAAPRSPALAAAPAGPSVSLYLSEDEVRRLLGLDAELYYVRNDLISHYALSFNLLVPSETNFLHFTWHAKSKVEYKLGFQVDNFVAMGMPQVNISAQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSSKNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITSSSGYPTLRIEKNDLRSVTLLEAKAKVKDIAISRERITLKDVLQEGTFGRIFHGILVDEKDPNKEKQTFVKTVKDQASEVQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVVLPYMNWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHRDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAALGAYV
uniprot
proteins
function
FUNCTION: May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development. {ECO:0000269|PubMed:15454084, ECO:0000269|PubMed:16116452, ECO:0000269|PubMed:16723543, ECO:0000269|PubMed:19000841}.
uniprot
proteins
mass_dalton
66285
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved, in part by presenilin, in response to WNT3 stimulation. {ECO:0000269|PubMed:19000841}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
11135307
uniprot
proteins
pubmed
1333503
uniprot
proteins
pubmed
1334548
uniprot
proteins
pubmed
15454084
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16116452
uniprot
proteins
pubmed
16723543
uniprot
proteins
pubmed
19000841
uniprot
proteins
pubmed
7822791
uniprot
proteins
pubmed
8380921
uniprot
proteins
pubmed
8394755
uniprot
proteins
sequence_length
594
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}. Nucleus {ECO:0000269|PubMed:19000841}. Cytoplasm {ECO:0000269|PubMed:19000841}. Note=In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus. {ECO:0000269|PubMed:19000841}.
uniprot
proteins
transmembrane_region
TRANSMEM 212..239; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins