SLC2A5
entrez
6518
canonical
uniprot
P22732
canonical
ensembl
ENSG00000142583
resolver
ensp
ENSP00000366631
resolver
ensp
ENSP00000366641
resolver
ensp
ENSP00000611891
resolver
genesymbol
SLC2A5
resolver
genesymbol_syn
GLUT5
resolver
hgnc
HGNC:11010
resolver
uniprot
A0A140VJK5
resolver
uniprot
B4DG19
resolver
uniprot
B4DT82
resolver
uniprot
Q14770
resolver
uniprot
Q5T977
resolver
uniprot
Q8IVB3
resolver
uniprot_entry
A0A140VJK5_HUMAN
resolver
uniprot_entry
B4DG19_HUMAN
resolver
uniprot_entry
B4DT82_HUMAN
resolver
uniprot_entry
GTR5_HUMAN
resolver
uniprot_sec
Q14770
resolver
uniprot_sec
Q5T977
resolver
uniprot_sec
Q8IVB3
resolver
activity_regulation
ACTIVITY REGULATION: The uptake of 2-deoxyglucose is inhibited by cytochalasin B. Fructose transport is inhibited by the flavonoids epigallocatechin gallate and apigenin but not quercetin (PubMed:29548810). {ECO:0000269|PubMed:1695905, ECO:0000269|PubMed:29548810}.
uniprot
proteins
amino_acid_sequence
MEQQDQSMKEGRLTLVLALATLIAAFGSSFQYGYNVAAVNSPALLMQQFYNETYYGRTGEFMEDFPLTLLWSVTVSMFPFGGFIGSLLVGPLVNKFGRKGALLFNNIFSIVPAILMGCSRVATSFELIIISRLLVGICAGVSSNVVPMYLGELAPKNLRGALGVVPQLFITVGILVAQIFGLRNLLANVDGWPILLGLTGVPAALQLLLLPFFPESPRYLLIQKKDEAAAKKALQTLRGWDSVDREVAEIRQEDEAEKAAGFISVLKLFRMRSLRWQLLSIIVLMGGQQLSGVNAIYYYADQIYLSAGVPEEHVQYVTAGTGAVNVVMTFCAVFVVELLGRRLLLLLGFSICLIACCVLTAALALQDTVSWMPYISIVCVISYVIGHALGPSPIPALLITEIFLQSSRPSAFMVGGSVHWLSNFTVGLIFPFIQEGLGPYSFIVFAVICLLTTIYIFLIVPETKAKTFIEINQIFTKMNKVSEVYPEKEELKELPPVTSEQ
uniprot
proteins
function
FUNCTION: Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:16186102, PubMed:17710649, PubMed:28083649, PubMed:29548810, PubMed:8333543). Can mediate the uptake of 2-deoxyglucose, but with low efficiency (PubMed:1695905). Essential for fructose uptake in the small intestine (By similarity). Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose (By similarity). Required for the development of high blood pressure in response to high dietary fructose intake (By similarity). {ECO:0000250|UniProtKB:Q9WV38, ECO:0000269|PubMed:16186102, ECO:0000269|PubMed:1695905, ECO:0000269|PubMed:17710649, ECO:0000269|PubMed:28083649, ECO:0000269|PubMed:29548810, ECO:0000269|PubMed:8333543}.
uniprot
proteins
mass_dalton
54974
uniprot
proteins
protein_family
Glucose transporter subfamily
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Sugar transporter (TC 2.A.1.1) family
uniprot
proteins
pubmed
11840567
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16186102
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
1695905
uniprot
proteins
pubmed
17710649
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
28083649
uniprot
proteins
pubmed
29548810
uniprot
proteins
pubmed
7619085
uniprot
proteins
pubmed
8037665
uniprot
proteins
pubmed
8333543
uniprot
proteins
sequence_length
501
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q9WV38}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9WV38}. Cell membrane {ECO:0000269|PubMed:1695905, ECO:0000269|PubMed:28083649, ECO:0000269|PubMed:7619085, ECO:0000269|PubMed:8333543}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9WV38}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:P43427}. Note=Localized on the apical membrane of jejunum villi, but also on lateral plasma membranes of the villi. Transport to the cell membrane is dependent on RAB11A. {ECO:0000250|UniProtKB:Q9WV38}.
uniprot
proteins
transmembrane_region
TRANSMEM 19..39; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P43427"; TRANSMEM 69..91; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P43427"; TRANSMEM 99..119; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P43427"; TRANSMEM 127..149; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P43427"; TRANSMEM 162..182; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P43427"; TRANSMEM 193..213; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P43427"; TRANSMEM 278..298; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P43427"; TRANSMEM 314..334; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P43427"; TRANSMEM 343..363; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:P43427"; TRANSMEM 372..394; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:P43427"; TRANSMEM 413..433; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:P43427"; TRANSMEM 440..460; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:P43427
uniprot
proteins