OAZ2
entrez
4947
canonical
uniprot
O95190
canonical
ensembl
ENSG00000180304
resolver
ensp
ENSP00000463013
resolver
enst
ENST00000326005
resolver
genesymbol
OAZ2
resolver
hgnc
HGNC:8096
resolver
uniprot_entry
OAZ2_HUMAN
resolver
amino_acid_sequence
MINTQDSSILPLSNCPQLQCCRHIVPGPLWCSDAPHPLSKIPGGRGGGRDPSLSALIYKDEKLTVTQDLPVNDGKPHIVHFQYEVTEVKVSSWDAVLSSQSLFVEIPDGLLADGSKEGLLALLEFAEEKMKVNYVFICFRKGREDRAPLLKTFSFLGFEIVRPGHPCVPSRPDVMFMVYPLDQNLSDED
uniprot
proteins
function
FUNCTION: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:17900240). Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (By similarity). {ECO:0000250|UniProtKB:O08608, ECO:0000269|PubMed:17900240}.
uniprot
proteins
mass_dalton
21011
uniprot
proteins
protein_family
ODC antizyme family
uniprot
proteins
pubmed
10352227
uniprot
proteins
pubmed
17900240
uniprot
proteins
pubmed
9782076
uniprot
proteins
sequence_length
189
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins