Bglap
entrez
25295
canonical
uniprot
P04640
canonical
ensembl
ENSRNOG00000019607
resolver
ensembl
ENSRNOG00055024058
resolver
ensembl
ENSRNOG00060032201
resolver
ensembl
ENSRNOG00065027655
resolver
ensp
ENSRNOP00000026530
resolver
ensp
ENSRNOP00055033634
resolver
ensp
ENSRNOP00060046169
resolver
ensp
ENSRNOP00065039117
resolver
enst
ENSRNOT00000026530
resolver
enst
ENSRNOT00055041332
resolver
enst
ENSRNOT00060055810
resolver
enst
ENSRNOT00065047694
resolver
genesymbol
Bglap
resolver
genesymbol_syn
Bglap2
resolver
uniprot_entry
OSTCN_RAT
resolver
amino_acid_sequence
MRTLSLLTLLALTAFCLSDLAGAKPSDSESDKAFMSKQEGSKVVNRLRRYLNNGLGAPAPYPDPLEPHREVCELNPNCDELADHIGFQDAYKRIYGTTV
uniprot
proteins
function
FUNCTION: The carboxylated form is one of the main organic components of the bone matrix, which constitutes 1-2% of the total bone protein (By similarity). Acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralization (By similarity). Binds strongly to apatite and calcium upon gamma-carboxylation; this modification is essential for bone metabolism (By similarity). {ECO:0000250|UniProtKB:P02818, ECO:0000250|UniProtKB:P86546}.; FUNCTION: The uncarboxylated form acts as a hormone secreted by osteoblasts, which regulates different cellular processes, such as energy metabolism, male fertility and brain development. Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation, insulin secretion and sensitivity and energy expenditure. Uncarboxylated osteocalcin hormone also promotes testosterone production in the testes: acts as a ligand for G protein-coupled receptor GPRC6A at the surface of Leydig cells, initiating a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner. Also acts as a regulator of brain development: osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons, initiating a signaling response that prevents neuronal apoptosis in the hippocampus, favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development. {ECO:0000250|UniProtKB:P86546}.
uniprot
proteins
mass_dalton
10927
uniprot
proteins
post_translational_modification
PTM: Carboxylated by vitamin K-dependent GGCX to form gamma-carboxyglutamate; these residues are essential for the binding of calcium (By similarity). Decarboxylation promotes the hormone activity (By similarity). {ECO:0000250|UniProtKB:P02818, ECO:0000250|UniProtKB:P86546, ECO:0000255|PROSITE-ProRule:PRU00463}.
uniprot
proteins
protein_family
Osteocalcin/matrix Gla protein family
uniprot
proteins
pubmed
2784002
uniprot
proteins
pubmed
2785907
uniprot
proteins
pubmed
3019668
uniprot
proteins
pubmed
3265336
uniprot
proteins
pubmed
3875856
uniprot
proteins
sequence_length
99
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P86546}.
uniprot
proteins