Itk
entrez
16428
canonical
uniprot
Q03526
canonical
ensembl
ENSMUSG00000020395
resolver
ensp
ENSMUSP00000020664
resolver
ensp
ENSMUSP00000098864
resolver
ensp
ENSMUSP00000104860
resolver
enst
ENSMUST00000020664
resolver
enst
ENSMUST00000101306
resolver
enst
ENSMUST00000109237
resolver
genesymbol
Itk
resolver
genesymbol_syn
Emt
resolver
genesymbol_syn
Tlk
resolver
genesymbol_syn
Tsk
resolver
uniprot
A1A559
resolver
uniprot
A1A560
resolver
uniprot
Q3U5G1
resolver
uniprot
Q5STT7
resolver
uniprot
Q5STT8
resolver
uniprot_entry
A1A559_MOUSE
resolver
uniprot_entry
A1A560_MOUSE
resolver
uniprot_entry
ITK_MOUSE
resolver
uniprot_entry
Q3U5G1_MOUSE
resolver
uniprot_entry
Q5STT7_MOUSE
resolver
uniprot_entry
Q5STT8_MOUSE
resolver
amino_acid_sequence
MNNFILLEEQLIKKSQQKRRTSPSNFKVRFFVLTKASLAYFEDRHGKKRTLKGSIELSRIKCVEIVKSDISIPCHYKYPFQTLVYLQVVHDNYLLYVFAPDCESRQRWVLTLKEETRNNNSLVSKYHPNFWMDGRWRCCSQLEKPAVGCAPYDPSKNASKKPLPPTPEDNRRSFQEPEETLVIALYDYQTNDPQELALRCDEEYYLLDSSEIHWWRVQDKNGHEGYAPSSYLVEKSPNNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTPGTYTVSVFTKAIISENPCIKHYHIKETNDSPKRYYVAEKYVFDSIPLLIQYHQYNGGGLVTRLRYPVCSWRQKAPVTAGLRYGKWVIQPSELTFVQEIGSGQFGLVHLGYWLNKDKVAIKTIQEGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRSQRGLFAAETLLGMCLDVCEGMAYLEKACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSSKSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASCHVYQIMNHCWKEKPEDRPPFSQLLSQLAEIAEAGL
uniprot
proteins
ec_number
2.7.10.2
uniprot
proteins
function
FUNCTION: Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. Required for TCR-mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2-positive subset of immature gamma-delta T-cells (PubMed:23562159). Phosphorylates TBX21 at 'Tyr-525' and mediates its interaction with GATA3 (PubMed:15662016). {ECO:0000269|PubMed:15662016, ECO:0000269|PubMed:21036902, ECO:0000269|PubMed:23562159}.
uniprot
proteins
mass_dalton
72292
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Tyr-517 in the activation loop of the kinase domain by LCK. Subsequent autophosphorylation at Tyr-186 leads to the kinase activation. The autophosphorylated Tyr-186 lies within the substrate binding sequence of the SH3 domain (By similarity). {ECO:0000250}.; PTM: Ubiquitinated. {ECO:0000250}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
TEC subfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
10213685
uniprot
proteins
pubmed
10570288
uniprot
proteins
pubmed
1280821
uniprot
proteins
pubmed
15662016
uniprot
proteins
pubmed
16860760
uniprot
proteins
pubmed
19597499
uniprot
proteins
pubmed
20237289
uniprot
proteins
pubmed
21036902
uniprot
proteins
pubmed
23562159
uniprot
proteins
pubmed
7524075
uniprot
proteins
pubmed
8421704
uniprot
proteins
pubmed
8476425
uniprot
proteins
pubmed
8777721
uniprot
proteins
pubmed
8943565
uniprot
proteins
pubmed
8985255
uniprot
proteins
sequence_length
625
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus {ECO:0000269|PubMed:15662016}. Note=Localizes in the vicinity of cell surface receptors in the plasma membrane after receptor stimulation. {ECO:0000250}.
uniprot
proteins