SEC11C
entrez
90701
canonical
uniprot
Q9BY50
canonical
ensembl
ENSG00000166562
resolver
ensp
ENSP00000465281
resolver
ensp
ENSP00000468633
resolver
ensp
ENSP00000520518
resolver
enst
ENST00000587834
resolver
enst
ENST00000588875
resolver
enst
ENST00000715778
resolver
genesymbol
SEC11C
resolver
genesymbol_syn
SEC11L3
resolver
genesymbol_syn
SPC21
resolver
genesymbol_syn
SPCS4C
resolver
hgnc
HGNC:23400
resolver
uniprot
B2RAA3
resolver
uniprot
K7EJQ7
resolver
uniprot_entry
K7EJQ7_HUMAN
resolver
uniprot_entry
SC11C_HUMAN
resolver
uniprot_sec
B2RAA3
resolver
amino_acid_sequence
MVRAGAVGAHLPASGLDIFGDLKKMNKRQLYYQVLNFAMIVSSALMIWKGLIVLTGSESPIVVVLSGSMEPAFHRGDLLFLTNFREDPIRAGEIVVFKVEGRDIPIVHRVIKVHEKDNGDIKFLTKGDNNEVDDRGLYKEGQNWLEKKDVVGRARGFLPYVGMVTIIMNDYPKFKYALLAVMGAYVLLKRES
uniprot
proteins
ec_number
3.4.21.89
uniprot
proteins
function
FUNCTION: Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:34388369). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (PubMed:34388369). {ECO:0000269|PubMed:34388369}.
uniprot
proteins
mass_dalton
21542
uniprot
proteins
mutagenesis
MUTAGEN 68; /note="S->A: Loss of catalytic activity."; /evidence="ECO:0000269|PubMed:34388369"; MUTAGEN 109; /note="R->D: Slight reduction in catalytic activity; when associated with R-128."; /evidence="ECO:0000269|PubMed:34388369"; MUTAGEN 128; /note="D->N: Moderate reduction in catalytic activity. Reduces protein stability."; /evidence="ECO:0000269|PubMed:34388369"; MUTAGEN 128; /note="D->R: Slight reduction in catalytic activity; when associated with D-109."; /evidence="ECO:0000269|PubMed:34388369"; MUTAGEN 133; /note="D->N: No effect on catalytic activity or protein stability."; /evidence="ECO:0000269|PubMed:34388369"; MUTAGEN 134; /note="D->N: Loss of catalytic activity. Slight reduction in protein stability."; /evidence="ECO:0000269|PubMed:34388369
uniprot
proteins
post_translational_modification
PTM: May undergo processing at the N-terminus. {ECO:0000269|PubMed:34388369}.
uniprot
proteins
protein_family
Peptidase S26B family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
34388369
uniprot
proteins
sequence_length
192
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P13679}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:P13679}.
uniprot
proteins
transmembrane_region
TRANSMEM 29..48; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins