Kash5
entrez
384619
canonical
uniprot
Q80VJ8
canonical
ensembl
ENSMUSG00000038292
resolver
ensp
ENSMUSP00000113616
resolver
enst
ENSMUST00000121017
resolver
genesymbol
Kash5
resolver
genesymbol_syn
Ccdc155
resolver
uniprot
E9QNS3
resolver
uniprot
E9QQ69
resolver
uniprot_entry
KASH5_MOUSE
resolver
uniprot_sec
E9QNS3
resolver
uniprot_sec
E9QQ69
resolver
amino_acid_sequence
MHSILRSSLSSREALRMRQLKGLRKERPGRHPLGVRLRAIWTSFLFPNPPHSGGKLRASTAAVEEHQEWSMDLPEGQAGGPTAQMYLWEQPEEASSRPLLSLEEQILNSTFEACDPHKTGTVTVAHLLAYLEAVTGQGPQDVRLQTLARSLDPYGEGAGATVELDTFLVVMRDWIAACQLQGGLERAEETAYEGALASPHLPSVCPEAEESANLESFGGEDPRPEGPATAELLSNLEDLELSNRRLAGENAKLQRSVETAEEGSARLGEEITALRKQLRSTQQALQVAKALDEELEDLKTLAKSLEEQNRSLMAQARHTEKEQQHLAAEVETLQEENEKLLAERDGVKRRSEELATEKDALKRQLCECERLICQREAVLSERTRHAESLARTLEEYRTTTQELRQEISNLEEQLSQSQEGPEELLEGAEAGRVGWIMALPPSLDLEIQAIRQEQDVASAGLSSPLYGVWQWEEVEPEPEPEPEPEPEPEPQEVEFPSEDPARQQTDLQREPVRALEGSRAPCLRLSRSQEEEEEEEESWVLADPSSPLGTYHHKLAPGSSRESCHIVPEMHQALMPVVRDLVPVERSRTQHCLHPQHSPGIRISQHPLVPTPVLGLLLLLLLSILLFSQSPPPTWPHLQLYYLQPPPV
uniprot
proteins
function
FUNCTION: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for telomere attachment to nuclear envelope in the prophase of meiosis and for rapid telomere prophase movements implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for homolog pairing during meiotic prophase in spermatocytes and probably oocytes. Essential for male and female gametogenesis. Recruits cytoplasmic dynein to telomere attachment sites at the nuclear envelope in spermatocytes. In oocytes is involved in meiotic resumption and spindle formation. {ECO:0000269|PubMed:24062341, ECO:0000269|PubMed:25892231, ECO:0000269|PubMed:26842404}.
uniprot
proteins
mass_dalton
72444
uniprot
proteins
mutagenesis
MUTAGEN 645..647; /note="PPP->AAA: Abolishes interaction with SUN1. Fails to localize at telomere."; /evidence="ECO:0000269|PubMed:22826121"; MUTAGEN 645..647; /note="Missing: Abolishes interaction with SUN1. Fails to localize at telomere."; /evidence="ECO:0000269|PubMed:22826121
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22826121
uniprot
proteins
pubmed
24062341
uniprot
proteins
pubmed
24586178
uniprot
proteins
pubmed
25892231
uniprot
proteins
pubmed
26842404
uniprot
proteins
pubmed
35674372
uniprot
proteins
sequence_length
648
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus outer membrane {ECO:0000269|PubMed:24062341, ECO:0000269|PubMed:26842404}; Single-pass type IV membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Nucleus {ECO:0000269|PubMed:22826121}. Chromosome, telomere {ECO:0000269|PubMed:22826121}. Nucleus envelope {ECO:0000250|UniProtKB:Q8N6L0}. Note=Localized exclusively at telomeres from the leptotene to diplotene stages. Colocalizes with SUN2 at sites of telomere attachment in meiocytes. At oocyte MI stage localized around the spindle, at MII stage localized to the spindle poles. {ECO:0000269|PubMed:24586178, ECO:0000269|PubMed:26842404}.
uniprot
proteins
transmembrane_region
TRANSMEM 607..627; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins