Clec4d
entrez
362432
canonical
uniprot
Q69FH1
canonical
ensembl
ENSRNOG00000067848
resolver
ensembl
ENSRNOG00055009392
resolver
ensembl
ENSRNOG00060027815
resolver
ensembl
ENSRNOG00065033481
resolver
ensp
ENSRNOP00000108621
resolver
ensp
ENSRNOP00055012740
resolver
ensp
ENSRNOP00060040196
resolver
ensp
ENSRNOP00065047379
resolver
enst
ENSRNOT00000135922
resolver
enst
ENSRNOT00055015880
resolver
enst
ENSRNOT00060048280
resolver
enst
ENSRNOT00065057549
resolver
genesymbol
Clec4d
resolver
genesymbol_syn
Clecsf8
resolver
genesymbol_syn
Mcl
resolver
uniprot
A0ABK0M494
resolver
uniprot
Q2TUL6
resolver
uniprot_entry
A0ABK0M494_RAT
resolver
uniprot_entry
CLC4D_RAT
resolver
uniprot_sec
Q2TUL6
resolver
amino_acid_sequence
MWLEESQMKSKGALHPRRIPWVCAVVSISFLSACFISTCVVTHYFLLWKRGSALKFSDYHTRLTCILEEPQPGATGGTWTCCPVSWRAFQSNCYFALNDNQTWHESERNCSGMSSHLVTINTEAEQDFVTQLLDEQFSYFLGLSYEKVEGQWQWVDKTPFNPNVVFWKVGEPKDSMEEDCVVLVYDQDKWVWNDFPCHFEMGRICKLPGATFDWNPSK
uniprot
proteins
function
FUNCTION: Calcium-dependent lectin that acts as a pattern recognition receptor (PRR) of the innate immune system: recognizes damage-associated molecular patterns (DAMPs) of pathogen-associated molecular patterns (PAMPs) of bacteria and fungi. The PAMPs include alpha-mannans on C.albicans hypheas and mycobacterial trehalose 6,6'-dimycolate (TDM) (By similarity). Interacts with signaling adapter Fc receptor gamma chain/FCER1G, likely via CLEC4E, to form a functional complex in myeloid cells (PubMed:23921530). Binding of mycobacterial TDM or C.albicans alpha-mannans to this receptor complex leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of FCER1G, triggering activation of SYK, CARD9 and NF-kappa-B, consequently driving maturation of antigen-presenting cells and shaping antigen-specific priming of T-cells toward effector T-helper 1 and T-helper 17 cell subtypes. The heterodimer formed with CLEC6A is active against fungal infection. Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T-cells (By similarity). {ECO:0000250|UniProtKB:Q8WXI8, ECO:0000269|PubMed:23921530}.
uniprot
proteins
mass_dalton
25312
uniprot
proteins
pubmed
15368084
uniprot
proteins
pubmed
23921530
uniprot
proteins
sequence_length
218
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:23921530}; Single-pass type II membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..47; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins