Ndn
entrez
17984
canonical
uniprot
P25233
canonical
ensembl
ENSMUSG00000033585
resolver
ensp
ENSMUSP00000045369
resolver
enst
ENSMUST00000038775
resolver
genesymbol
Ndn
resolver
uniprot
B9EJJ5
resolver
uniprot
Q542W7
resolver
uniprot
Q61951
resolver
uniprot_entry
NECD_MOUSE
resolver
uniprot_sec
B9EJJ5
resolver
uniprot_sec
Q542W7
resolver
uniprot_sec
Q61951
resolver
amino_acid_sequence
MSEQSKDLSDPNFAAEVPDCEMQDSDAVPVGIPPPASLAANLAGPPCAPEGPMAAQQASPPPEERIEDVDPKILQQAAEEGRAHQPQSPARPIPAPPAPAQLVQKAHELMWYVLVKDQKRMVLWFPDMVKEVMGSYKKWCRSILRRTSVILARVFGLHLRLTNLHTMEFALVKALSPEELDRVALNNRMPMTGLLLMILSLIYVKGRGAREGAVWNVLRILGLRPWKKHSTFGDVRKIITEEFVQQNYLKYQRVPHIEPPEYEFFWGSRANREITKMQIMEFLARVFKKDPQAWPSRYREALEQARALREANLAAQAPRSSVSED
uniprot
proteins
function
FUNCTION: Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Also functions as a transcription factor and directly binds to specific guanosine-rich DNA sequences.
uniprot
proteins
mass_dalton
36832
uniprot
proteins
pubmed
10347180
uniprot
proteins
pubmed
10965153
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
2069569
uniprot
proteins
pubmed
8557705
uniprot
proteins
pubmed
9422723
uniprot
proteins
sequence_length
325
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10965153}. Nucleus, nucleoplasm {ECO:0000269|PubMed:10965153}. Nucleus matrix {ECO:0000269|PubMed:10965153}. Note=Mainly cytoplasmic. Translocates to the nucleus where it is found associated with the nuclear matrix.
uniprot
proteins