TMEM217
entrez
221468
canonical
uniprot
Q8N7C4
canonical
ensembl
ENSG00000172738
resolver
ensp
ENSP00000338164
resolver
ensp
ENSP00000349198
resolver
ensp
ENSP00000498333
resolver
ensp
ENSP00000498422
resolver
ensp
ENSP00000498862
resolver
ensp
ENSP00000499097
resolver
ensp
ENSP00000499204
resolver
ensp
ENSP00000764409
resolver
enst
ENST00000357219
resolver
enst
ENST00000652218
resolver
enst
ENST00000652495
resolver
enst
ENST00000652639
resolver
genesymbol
TMEM217
resolver
genesymbol_syn
C6orf128
resolver
hgnc
HGNC:21238
resolver
uniprot
A0A494C081
resolver
uniprot
A0A494C140
resolver
uniprot
A0A494C1J7
resolver
uniprot
Q8TC54
resolver
uniprot_entry
A0A494C081_HUMAN
resolver
uniprot_entry
A0A494C140_HUMAN
resolver
uniprot_entry
A0A494C1J7_HUMAN
resolver
uniprot_entry
TM217_HUMAN
resolver
uniprot_sec
Q8TC54
resolver
amino_acid_sequence
MKQQQWCGMTAKMGTVLSGVFTIMAVDMYLIFEQKHLGNGSCTEITPKYRGASNIINNFIICWSFKIVLFLSFITILISCFLLYSVYAQIFRGLVIYIVWIFFYETANVVIQILTNNDFDIKEVRIMRWFGLVSRTVMHCFWMFFVINYAHITYKNRSQGNIISYKRRISTAEILHSRNKRLSISSGFSGSHLESQYFERQSFHTSIFTCLSPVPSSAPSTCRYTIDVC
uniprot
proteins
function
FUNCTION: Transmembrane protein essential for sperm motility and male fertility. Forms a complex with SLC9C1 in the flagellum, which regulates sperm motility by maintaining the stability of soluble adenylyl cyclase, which produces cAMP to power flagellar movement. {ECO:0000250|UniProtKB:Q14AF1}.
uniprot
proteins
mass_dalton
26582
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
229
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium, flagellum membrane {ECO:0000250|UniProtKB:Q14AF1}; Multi-pass membrane protein {ECO:0000255}. Note=Localized in the principal piece of cauda epididymal sperm flagella. {ECO:0000250|UniProtKB:Q14AF1}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..33; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 67..87; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 94..114; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 129..149; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins