FRK
entrez
2444
canonical
uniprot
P42685
canonical
ensembl
ENSG00000111816
resolver
ensp
ENSP00000476145
resolver
ensp
ENSP00000561286
resolver
genesymbol
FRK
resolver
genesymbol_syn
PTK5
resolver
genesymbol_syn
RAK
resolver
hgnc
HGNC:3955
resolver
uniprot
B4DY49
resolver
uniprot
Q13128
resolver
uniprot
Q9NTR5
resolver
uniprot_entry
FRK_HUMAN
resolver
uniprot_sec
B4DY49
resolver
uniprot_sec
Q13128
resolver
uniprot_sec
Q9NTR5
resolver
amino_acid_sequence
MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETDSSYSDANNFIR
uniprot
proteins
ec_number
2.7.10.2
uniprot
proteins
function
FUNCTION: Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. {ECO:0000269|PubMed:19345329}.
uniprot
proteins
mass_dalton
58254
uniprot
proteins
mutagenesis
MUTAGEN 262; /note="K->R: Loss of ability to phosphorylate PTEN."; /evidence="ECO:0000269|PubMed:19345329
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
SRC subfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19345329
uniprot
proteins
pubmed
19652529
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
7510261
uniprot
proteins
pubmed
7664264
uniprot
proteins
pubmed
7696183
uniprot
proteins
pubmed
8099900
uniprot
proteins
sequence_length
505
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:7696183}. Nucleus {ECO:0000269|PubMed:7696183}. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery.
uniprot
proteins