Phax
entrez
286917
canonical
uniprot
Q63068
canonical
ensembl
ENSRNOG00000014459
resolver
ensembl
ENSRNOG00055013404
resolver
ensp
ENSRNOP00000019627
resolver
ensp
ENSRNOP00055018628
resolver
enst
ENSRNOT00055022975
resolver
genesymbol
Phax
resolver
genesymbol_syn
Rnuxa
resolver
uniprot
Q4QQW9
resolver
uniprot
Q5RJZ7
resolver
uniprot_entry
PHAX_RAT
resolver
uniprot_sec
Q4QQW9
resolver
uniprot_sec
Q5RJZ7
resolver
amino_acid_sequence
MALEAGDMEEGQLSDSDSDMTVVPSDRPLQMAKVLGGGGAACAPVSNYRTVKHVDSSEESLDSDDDCSLWKRKRQKCHSPPPKPEPFPFGQSGQKPALNGGKKVNNIWGAVLQEQNQDAVATELGILGMEGTIDRSRQSETYNYLLAKKLAKKESQEYTKELDKDLDEYMHGDKKPGSKEEENGQGHLKRKRPVRDRLGNRVEMNYKGRYDITEEDSPEKVADEIAFRLQEPKKDLIARVVTILGNKKAIELLMETAEVEQNGGLFIMNGSRRRTPGGVFLNLLKNTPSISEEQIKDIFYIENQKEYENKKAARKRRTQLLGKKMKEAIKSLNFQEDDDTSRETFASDTNEALASLDEAQEGPGETKLDAEDAIEVDHPQDLDIF
uniprot
proteins
function
FUNCTION: A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner. Also plays a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Also binds to telomerase RNA (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
43166
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in the nucleus. Dephosphorylated in the cytoplasm.
uniprot
proteins
protein_family
PHAX family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8015392
uniprot
proteins
sequence_length
385
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H814}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9H814}. Nucleus, Cajal body {ECO:0000250|UniProtKB:Q9H814}. Cytoplasm {ECO:0000250|UniProtKB:Q9H814}. Note=Shuttles between the nucleus and the cytoplasm. Shuttles between the nucleoplasm and Cajal bodies. {ECO:0000250|UniProtKB:Q9H814}.
uniprot
proteins