Atp6v0b
entrez
114143
canonical
uniprot
Q91V37
canonical
ensembl
ENSMUSG00000033379
resolver
ensp
ENSMUSP00000047682
resolver
ensp
ENSMUSP00000119988
resolver
enst
ENSMUST00000036380
resolver
enst
ENSMUST00000150204
resolver
genesymbol
Atp6v0b
resolver
genesymbol_syn
Atp6f
resolver
uniprot
A0A0A0MQJ5
resolver
uniprot
Q3U889
resolver
uniprot_entry
A0A0A0MQJ5_MOUSE
resolver
uniprot_entry
Q3U889_MOUSE
resolver
uniprot_entry
VATO_MOUSE
resolver
amino_acid_sequence
MTGLELLYLGIFVAFWACMVVVGICYTIFDLGFRFDVAWFLTETSPFMWSNLGIGLAISLSVVGAAWGIYITGSSIIGGGVKAPRIKTKNLVSIIFCEAVAIYGIIMAIVISNMAEPFSATEPKAIGHRNYHAGYSMFGAGLTVGLSNLFCGVCVGIVGSGAALADAQNPSLFVKILIVEIFGSAIGLFGVIVAILQTSRVKMGD
uniprot
proteins
function
FUNCTION: Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it promotes acidification of the extracellular environment (By similarity). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity). {ECO:0000250|UniProtKB:Q2TA24, ECO:0000250|UniProtKB:Q99437}.
uniprot
proteins
mass_dalton
21607
uniprot
proteins
protein_family
V-ATPase proteolipid subunit family
uniprot
proteins
pubmed
11441017
uniprot
proteins
pubmed
11675001
uniprot
proteins
pubmed
22467717
uniprot
proteins
pubmed
38555350
uniprot
proteins
sequence_length
205
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000250|UniProtKB:Q2TA24}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 52..72; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 91..111; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 138..158; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 176..196; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins