Trip10
entrez
106628
canonical
uniprot
Q8CJ53
canonical
ensembl
ENSMUSG00000019487
resolver
ensp
ENSMUSP00000019631
resolver
ensp
ENSMUSP00000153081
resolver
ensp
ENSMUSP00000153467
resolver
ensp
ENSMUSP00000153576
resolver
ensp
ENSMUSP00000265043
resolver
ensp
ENSMUSP00000265044
resolver
ensp
ENSMUSP00000265045
resolver
ensp
ENSMUSP00000265046
resolver
ensp
ENSMUSP00000265047
resolver
genesymbol
Trip10
resolver
genesymbol_syn
Cip4
resolver
uniprot
Q8BTR8
resolver
uniprot
Q8R433
resolver
uniprot
Q99LI0
resolver
uniprot_entry
CIP4_MOUSE
resolver
uniprot_sec
Q8BTR8
resolver
uniprot_sec
Q8R433
resolver
uniprot_sec
Q99LI0
resolver
amino_acid_sequence
MDWGTELWDQFEVLERHTQWGLDLLDKYVKFVKERAEVEQAYAKQLRSLVKKYLPKRPTKDDPEVKFSQQQSFVQLLQEVNDFAGQRELVAESLGIRVCLELAKYSQEMKQERKMHFQEGRRAQQQLENGFKQLENSKRKFERDCREAEKAAHTAERLDQDINATKADVEKAKQQAHLRNHMAEESKNEYAAQLQRFNRDQAHFYFSQMPQIFDKLQDMDERRATRLGAGYGLLSEAELQVVPIIGKCLEGMKVAAESVDAKNDSQVLIELHKSGFARPGDLEFEDFSQVINRVPSDSSLGTPDGRPELRAASSRSRAKRWPFGKKNKPRPPSLSLLGGHLPSTLSDGPSSPRSGRDPLAILSEISKSVKPRLASFRSFRGGRGTVATEDFSHLPPEQQRKRLQQQLEERNRELQKEEDQREALKKMKDVYEKTPQMGDPASLEPRIAETLGNIERLKLEVQKYEAWLAEAESRVLSNRGDSLSRHARPPDPPTTAPPDSSSSSTNSGSQDNKESSSEEPPSEGQDTPIYTEFDEDFEEPASPIGQCVAIYHFEGSSEGTVSMSEGEDLSLMEEDKGDGWTRVRRKQGAEGYVPTSYLRVTLN
uniprot
proteins
function
FUNCTION: Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL (By similarity). Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling. {ECO:0000250, ECO:0000269|PubMed:12242347, ECO:0000269|PubMed:16418535}.
uniprot
proteins
mass_dalton
68489
uniprot
proteins
mutagenesis
MUTAGEN 454; /note="I->S: Impairs interaction with CDC42 and RHOQ and reduces insulin-stimulated translocation to the plasma membrane."; /evidence="ECO:0000269|PubMed:12242347
uniprot
proteins
post_translational_modification
PTM: Tyrosine phosphorylated. Also phosphorylated by PKA (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
FNBP1 family
uniprot
proteins
pubmed
12054674
uniprot
proteins
pubmed
12242347
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16418535
uniprot
proteins
pubmed
16735024
uniprot
proteins
pubmed
17189207
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
603
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Golgi apparatus {ECO:0000250}. Cell membrane. Cell projection, phagocytic cup {ECO:0000250}. Note=Localizes to cortical regions coincident with F-actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9 (By similarity). Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ. {ECO:0000250}.
uniprot
proteins