Elk1
entrez
314436
canonical
uniprot
A4GTP4
canonical
ensembl
ENSRNOG00000010171
resolver
ensembl
ENSRNOG00055016359
resolver
ensembl
ENSRNOG00060019596
resolver
ensembl
ENSRNOG00065020252
resolver
ensp
ENSRNOP00000013522
resolver
ensp
ENSRNOP00055022271
resolver
ensp
ENSRNOP00060027736
resolver
ensp
ENSRNOP00065027364
resolver
enst
ENSRNOT00000013522
resolver
enst
ENSRNOT00055027739
resolver
enst
ENSRNOT00060033863
resolver
enst
ENSRNOT00065034184
resolver
genesymbol
Elk1
resolver
uniprot_entry
ELK1_RAT
resolver
amino_acid_sequence
MDPSVTLWQFLLQLLREQGNGHIISWTSRDGGEFKLVDAEEVARLWGLRKNKTNMNYDKLSRALRYYYDKNIIRKVSGQKFVYKFVSYPEVAGCSTEDCPPQPEVSVTSAVAMAPATVHSGPGDNATGKPGTPKGAGMTGQGGLARSSRNEYMRSGLYSTFTIQSLQPQPPLHPRPASVLPNTTPAGVPAPPSGSRSTSPNPLEACLEAEEAGLPLQVILTPPEAPNQKSEELSLNPGFGRPQPPEVKVEGPKEELEVTEVGGFSPEAVKAEQEVSPSEGLLARLPAILTENTAQVCGLSTSTTEITQPQKGRKPRDLELPLSPSLLGGQGPERTPGSGTSSGLQAQGPALTPSLLPTHTLTPVLLTPSSLPPSIHFWSTLSPIAPRSPAKLSFQFPSSGSAQVHIPSISVDGLSTPVVLSPGPQKP
uniprot
proteins
function
FUNCTION: Transcription factor that binds to purine-rich DNA sequences. Forms a ternary complex with SRF and the ETS and SRF motifs of the serum response element (SRE) on the promoter region of immediate early genes such as FOS and IER2 (By similarity) (PubMed:17156131). Induces target gene transcription upon JNK and MAPK-signaling pathways stimulation (PubMed:17156131). {ECO:0000250|UniProtKB:P19419, ECO:0000269|PubMed:17156131}.
uniprot
proteins
mass_dalton
45272
uniprot
proteins
post_translational_modification
PTM: Sumoylation represses transcriptional activator activity as it results in recruitment of HDAC2 to target gene promoters which leads to decreased histone acetylation and reduced transactivator activity. It also regulates nuclear retention. {ECO:0000250|UniProtKB:P19419}.; PTM: On mitogenic stimulation, phosphorylated on C-terminal serine and threonine residues by MAPK1. Ser-382 and Ser-388 are the preferred sites for MAPK1. In vitro, phosphorylation by MAPK1 potentiates ternary complex formation with the serum responses factors, SRE and SRF. Also phosphorylated on Ser-382 by MAPK8 and/or MAKP9. Phosphorylation leads to loss of sumoylation and restores transcriptional activator activity. Phosphorylated and activated by CAMK4, MAPK11, MAPK12 and MAPK14 (By similarity). Upon bFGF stimulus, phosphorylated by PAK1 (PubMed:17156131). Phosphorylated by PRP4K at Thr-416; phosphorylation activation ELK1 transcriptional activity (By similarity). {ECO:0000250|UniProtKB:P19419, ECO:0000269|PubMed:17156131}.
uniprot
proteins
protein_family
ETS family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
17156131
uniprot
proteins
sequence_length
427
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P19419}.
uniprot
proteins