Coxfa4l3
entrez
433470
canonical
uniprot
Q810Q5
canonical
ensembl
ENSMUSG00000033213
resolver
ensp
ENSMUSP00000040781
resolver
ensp
ENSMUSP00000106141
resolver
enst
ENSMUST00000047498
resolver
enst
ENSMUST00000110512
resolver
genesymbol
Coxfa4l3
resolver
genesymbol_syn
AA467197
resolver
genesymbol_syn
Nmes1
resolver
uniprot
Q3UCF3
resolver
uniprot_entry
CX4L3_MOUSE
resolver
uniprot_entry
Q3UCF3_MOUSE
resolver
amino_acid_sequence
MGVFQILMKNKELIPLAFFISVAATGATSFALYALKKTDVVIDRKRNPEPWEMVDPTQPQKLITINQQWKPVEELQKVRRATR
uniprot
proteins
function
FUNCTION: Mitochondrial small peptide that orchestrates a two-pronged immunoregulatory mechanism in response to inflammatory stimuli. Replaces the canonical cytochrome c oxidase subunit COXFA4 in mitochondrial complex IV and targets it to degradation, attenuating mitochondrial respiration, reducing membrane potential as well as ROS generation and modulates innate immune signaling (PubMed:34878835, PubMed:38917002). Additionally, initiates stress-independent autophagy by lowering ATP levels, activating AMPK-ULK1 signaling, boosting glutathione production, and thereby mitigating oxidative stress and supporting immune tolerance (PubMed:38296961). {ECO:0000269|PubMed:34878835, ECO:0000269|PubMed:38296961, ECO:0000269|PubMed:38917002}.
uniprot
proteins
mass_dalton
9584
uniprot
proteins
protein_family
Complex IV COXFA4 subunit family
uniprot
proteins
pubmed
12209954
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
34878835
uniprot
proteins
pubmed
38296961
uniprot
proteins
pubmed
38917002
uniprot
proteins
sequence_length
83
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:38296961, ECO:0000305|PubMed:38917002}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..35; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins