GSTZ1
entrez
2954
canonical
uniprot
O43708
canonical
ensembl
ENSG00000100577
resolver
ensp
ENSP00000216465
resolver
ensp
ENSP00000314404
resolver
ensp
ENSP00000354959
resolver
ensp
ENSP00000377335
resolver
ensp
ENSP00000451976
resolver
enst
ENST00000216465
resolver
enst
ENST00000349555
resolver
enst
ENST00000553586
resolver
genesymbol
GSTZ1
resolver
genesymbol_syn
MAAI
resolver
hgnc
HGNC:4643
resolver
uniprot
A0A0A0MR33
resolver
uniprot
A0A0C4DFM0
resolver
uniprot
A6NED0
resolver
uniprot
A6NNB8
resolver
uniprot
A8MWD7
resolver
uniprot
B2RCK3
resolver
uniprot
G3V4T6
resolver
uniprot
O15308
resolver
uniprot
O75430
resolver
uniprot
Q6IB17
resolver
uniprot
Q7Z610
resolver
uniprot
Q9BV63
resolver
uniprot_entry
A0A0A0MR33_HUMAN
resolver
uniprot_entry
A0A0C4DFM0_HUMAN
resolver
uniprot_entry
G3V4T6_HUMAN
resolver
uniprot_entry
MAAI_HUMAN
resolver
uniprot_sec
A6NED0
resolver
uniprot_sec
A6NNB8
resolver
uniprot_sec
A8MWD7
resolver
uniprot_sec
B2RCK3
resolver
uniprot_sec
O15308
resolver
uniprot_sec
O75430
resolver
uniprot_sec
Q6IB17
resolver
uniprot_sec
Q7Z610
resolver
uniprot_sec
Q9BV63
resolver
amino_acid_sequence
MQAGKPILYSYFRSSCSWRVRIALALKGIDYKTVPINLIKDRGQQFSKDFQALNPMKQVPTLKIDGITIHQSLAIIEYLEEMRPTPRLLPQDPKKRASVRMISDLIAGGIQPLQNLSVLKQVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMADLCLVPQVANAERFKVDLTPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA
uniprot
proteins
disease_involvement
DISEASE: Maleylacetoacetate isomerase deficiency (MAAID) [MIM:617596]: An autosomal recessive inborn error of metabolism characterized by mild elevations in succinylacetone in blood and urine, usually identified by newborn screening. Liver function and coagulation are normal. MAAID is a benign disorder. {ECO:0000269|PubMed:27876694}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.5.1.18
uniprot
proteins
ec_number
5.2.1.2
uniprot
proteins
function
FUNCTION: Bifunctional enzyme showing minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. Also has low glutathione peroxidase activity with T-butyl and cumene hydroperoxides. Is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid. {ECO:0000269|PubMed:10739172}.
uniprot
proteins
mass_dalton
24212
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 5/6.
uniprot
proteins
protein_family
GST superfamily
uniprot
proteins
protein_family
Zeta family
uniprot
proteins
pubmed
10373324
uniprot
proteins
pubmed
10739172
uniprot
proteins
pubmed
11327815
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
27876694
uniprot
proteins
pubmed
9396740
uniprot
proteins
pubmed
9417084
uniprot
proteins
pubmed
9531472
uniprot
proteins
pubmed
9925947
uniprot
proteins
sequence_length
216
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins