Noct
entrez
12457
canonical
uniprot
O35710
canonical
ensembl
ENSMUSG00000023087
resolver
ensp
ENSMUSP00000023849
resolver
genesymbol
Noct
resolver
genesymbol_syn
Ccr4
resolver
genesymbol_syn
Ccrn4l
resolver
genesymbol_syn
Noc
resolver
uniprot
B2RTJ8
resolver
uniprot
Q9QZG9
resolver
uniprot_entry
B2RTJ8_MOUSE
resolver
uniprot_entry
NOCT_MOUSE
resolver
uniprot_sec
Q9QZG9
resolver
amino_acid_sequence
MYQSPRRLCSALLLRDAPGLRRTLVPGPRRTLAPPVLGSRPKSPQLQAAAASGAARSRPRTVSSMGNGTSRLYSALAKTVNSSAAAQHPEYLVSTDPEHLEPIDPKELLEECRAVLHTRPPRYQRDFVDLRTDCSSSHSPIRVMQWNILAQALGEGKDNFVQCPVEALKWEERKCLILEEILAYQPDILCLQEVDHYFDTFQPLLSRLGYQGTFFPKPWSPCLDVEHNNGPDGCALFFLQNRFKLISSTNIRLTAMTLKTNQVAIAQTLECKESGRQFCIAVTHLKARTGWERFRSAQGCDLLQNLQNITQGAKIPLIVCGDFNAEPTEEVYKHFASSSLNLNSAYKLLSPDGQSEPPYTTWKIRTSGECRHTLDYIWYSRHALSVTSALDLLTEEQIGPNRLPSFHYPSDHLSLVCDFSFNEEPHELF
uniprot
proteins
ec_number
3.1.3.108
uniprot
proteins
function
FUNCTION: Phosphatase which catalyzes the conversion of NADP(+) to NAD(+) and of NADPH to NADH (By similarity). Shows a small preference for NADPH over NADP(+) (By similarity). Represses translation and promotes degradation of target mRNA molecules (By similarity). Plays an important role in post-transcriptional regulation of metabolic genes under circadian control (PubMed:20498072, PubMed:20685873). Exerts a rhythmic post-transcriptional control of genes necessary for metabolic functions including nutrient absorption, glucose/insulin sensitivity, lipid metabolism, adipogenesis, inflammation and osteogenesis (PubMed:20498072, PubMed:21820310, PubMed:22073225, PubMed:22082366, PubMed:22331129). Plays an important role in favoring adipogenesis over osteoblastogenesis and acts as a key regulator of the adipogenesis/osteogenesis balance (PubMed:20498072, PubMed:22082366). Promotes adipogenesis by facilitating PPARG nuclear translocation which activates its transcriptional activity (PubMed:20498072). Regulates circadian expression of NOS2 in the liver and negatively regulates the circadian expression of IGF1 in the bone (PubMed:20685873, PubMed:22073225). Critical for proper development of early embryos (PubMed:23449310). {ECO:0000250|UniProtKB:Q9UK39, ECO:0000269|PubMed:20498072, ECO:0000269|PubMed:20685873, ECO:0000269|PubMed:21820310, ECO:0000269|PubMed:22073225, ECO:0000269|PubMed:22082366, ECO:0000269|PubMed:22331129, ECO:0000269|PubMed:23449310}.
uniprot
proteins
mass_dalton
48301
uniprot
proteins
protein_family
CCR4/nocturin family
uniprot
proteins
pubmed
10521507
uniprot
proteins
pubmed
11394964
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17400819
uniprot
proteins
pubmed
20392228
uniprot
proteins
pubmed
20498072
uniprot
proteins
pubmed
20685873
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21820310
uniprot
proteins
pubmed
22073225
uniprot
proteins
pubmed
22082366
uniprot
proteins
pubmed
22331129
uniprot
proteins
pubmed
23449310
uniprot
proteins
pubmed
29860338
uniprot
proteins
pubmed
9038221
uniprot
proteins
sequence_length
429
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23449310}. Nucleus {ECO:0000269|PubMed:23449310}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:20498072}. Mitochondrion {ECO:0000250|UniProtKB:Q9UK39}.
uniprot
proteins