HHEX
entrez
3087
canonical
uniprot
Q03014
canonical
ensembl
ENSG00000152804
resolver
ensp
ENSP00000282728
resolver
enst
ENST00000282728
resolver
genesymbol
HHEX
resolver
genesymbol_syn
HEX
resolver
genesymbol_syn
PRH
resolver
genesymbol_syn
PRHX
resolver
hgnc
HGNC:4901
resolver
uniprot
B1AQ17
resolver
uniprot
Q96CE9
resolver
uniprot_entry
HHEX_HUMAN
resolver
uniprot_sec
B1AQ17
resolver
uniprot_sec
Q96CE9
resolver
amino_acid_sequence
MQYPHPGPAAGAVGVPLYAPTPLLQPAHPTPFYIEDILGRGPAAPTPAPTLPSPNSSFTSLVSPYRTPVYEPTPIHPAFSHHSAAALAAAYGPGGFGGPLYPFPRTVNDYTHALLRHDPLGKPLLWSPFLQRPLHKRKGGQVRFSNDQTIELEKKFETQKYLSPPERKRLAKMLQLSERQVKTWFQNRRAKWRRLKQENPQSNKKEELESLDSSCDQRQDLPSEQNKGASLDSSQCSPSPASQEDLESEISEDSDQEVDIEGDKSYFNAG
uniprot
proteins
function
FUNCTION: Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor (By similarity). Activator of WNT-mediated transcription in conjunction with CTNNB1 (PubMed:20028982). Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL (By similarity). Inhibits EIF4E-mediated mRNA nuclear export (PubMed:12554669). May play a role in hematopoietic differentiation (PubMed:8096636). {ECO:0000250|UniProtKB:P43120, ECO:0000269|PubMed:12554669, ECO:0000269|PubMed:20028982, ECO:0000269|PubMed:8096636}.
uniprot
proteins
mass_dalton
30022
uniprot
proteins
mutagenesis
MUTAGEN 23..24; /note="LL->AA: Abolishes interaction with EIF4E and inhibitory effect on EIF4E-mediated mRNA nuclear export."; /evidence="ECO:0000269|PubMed:12554669"; MUTAGEN 188; /note="R->A: Loss of nuclear localization; when associated with A-189."; /evidence="ECO:0000269|PubMed:12554669"; MUTAGEN 189; /note="R->A: Loss of nuclear localization; when associated with A-188."; /evidence="ECO:0000269|PubMed:12554669
uniprot
proteins
pubmed
12554669
uniprot
proteins
pubmed
1360645
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20028982
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
7911091
uniprot
proteins
pubmed
8096636
uniprot
proteins
pubmed
8103988
uniprot
proteins
sequence_length
270
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P43120}. Nucleus, nuclear body {ECO:0000269|PubMed:12554669}. Cytoplasm {ECO:0000269|PubMed:12554669}.
uniprot
proteins