CD151
entrez
977
canonical
uniprot
P48509
canonical
ensembl
ENSG00000177697
resolver
ensp
ENSP00000324101
resolver
ensp
ENSP00000380565
resolver
ensp
ENSP00000380566
resolver
ensp
ENSP00000432385
resolver
ensp
ENSP00000560825
resolver
ensp
ENSP00000560827
resolver
ensp
ENSP00000560828
resolver
ensp
ENSP00000560833
resolver
ensp
ENSP00000560836
resolver
ensp
ENSP00000560837
resolver
ensp
ENSP00000560838
resolver
ensp
ENSP00000560841
resolver
ensp
ENSP00000560842
resolver
ensp
ENSP00000560844
resolver
ensp
ENSP00000560845
resolver
ensp
ENSP00000560846
resolver
ensp
ENSP00000589436
resolver
ensp
ENSP00000589437
resolver
ensp
ENSP00000589442
resolver
ensp
ENSP00000616363
resolver
ensp
ENSP00000616368
resolver
ensp
ENSP00000616369
resolver
ensp
ENSP00000616370
resolver
enst
ENST00000322008
resolver
enst
ENST00000397420
resolver
enst
ENST00000397421
resolver
enst
ENST00000530726
resolver
enst
ENST00000890766
resolver
enst
ENST00000890768
resolver
enst
ENST00000890769
resolver
enst
ENST00000890774
resolver
enst
ENST00000890777
resolver
enst
ENST00000890778
resolver
enst
ENST00000890779
resolver
enst
ENST00000890782
resolver
enst
ENST00000890783
resolver
enst
ENST00000890785
resolver
enst
ENST00000890786
resolver
enst
ENST00000890787
resolver
enst
ENST00000919377
resolver
enst
ENST00000919378
resolver
enst
ENST00000919383
resolver
enst
ENST00000946304
resolver
enst
ENST00000946309
resolver
enst
ENST00000946310
resolver
enst
ENST00000946311
resolver
genesymbol
CD151
resolver
genesymbol_syn
TSPAN24
resolver
hgnc
HGNC:1630
resolver
uniprot
A8KAK8
resolver
uniprot
E9PI15
resolver
uniprot
Q14826
resolver
uniprot
Q6ZNZ0
resolver
uniprot
Q86U54
resolver
uniprot
Q96TE3
resolver
uniprot_entry
CD151_HUMAN
resolver
uniprot_entry
Q6ZNZ0_HUMAN
resolver
uniprot_sec
A8KAK8
resolver
uniprot_sec
E9PI15
resolver
uniprot_sec
Q14826
resolver
uniprot_sec
Q86U54
resolver
uniprot_sec
Q96TE3
resolver
amino_acid_sequence
MGEFNEKKTTCGTVCLKYLLFTYNCCFWLAGLAVMAVGIWTLALKSDYISLLASGTYLATAYILVVAGTVVMVTGVLGCCATFKERRNLLRLYFILLLIIFLLEIIAGILAYAYYQQLNTELKENLKDTMTKRYHQPGHEAVTSAVDQLQQEFHCCGSNNSQDWRDSEWIRSQEAGGRVVPDSCCKTVVALCGQRDHASNIYKVEGGCITKLETFIQEHLRVIGAVGIGIACVQVFGMIFTCCLYRSLKLEHY
uniprot
proteins
disease_involvement
DISEASE: Epidermolysis bullosa simplex 7, with nephropathy and deafness (EBS7) [MIM:609057]: A form of epidermolysis bullosa, a genodermatosis characterized by recurrent blistering, fragility of the skin and mucosal epithelia, and erosions caused by minor mechanical trauma. EBS7 is an autosomal recessive disorder characterized by the association of skin blistering, hereditary nephritis, sensorineural deafness, and beta-thalassemia minor. Skin blistering is present at birth, particularly in the tibial area but also scattered on other parts of the body. {ECO:0000269|PubMed:15265795}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Plays a role in various cellular and molecular mechanism through its association with both integrin and non-integrin proteins. These interactions facilitate critical cellular functions, including cell-to-cell communication, wound healing, platelet aggregation, trafficking, cell motility, and angiogenesis (PubMed:17045834, PubMed:24723389, PubMed:31488507). Via interaction with JAM-A/F11R and integrin ITGA3:ITGB1, promotes the recruitment of signaling molecules such as RAC1, CDC42 and RhoGTPases to facilitate the polarization of epithelial cells and the reorganization of the actin cytoskeleton, which are critical steps in cell migration process (PubMed:22843693, PubMed:35067832). Regulates the glycosylation pattern of ITGA3:ITGB1 thereby modulating its activity (PubMed:18852263). Plays an essential role in the maintenance of central laminin-binding integrin ITGA6:ITGB4-containing adhesion complexes (PubMed:31488507). Essential for the proper assembly of the glomerular and tubular basement membranes in kidney (PubMed:15265795). Contributes to T-cell activation by modulating integrin signaling leading to activation of downstream targets PTK2 and MAPK1/MAPK3 (PubMed:24723389). {ECO:0000269|PubMed:15265795, ECO:0000269|PubMed:17045834, ECO:0000269|PubMed:18852263, ECO:0000269|PubMed:22843693, ECO:0000269|PubMed:24723389, ECO:0000269|PubMed:31488507, ECO:0000269|PubMed:35067832}.; FUNCTION: (Microbial infection) Plays a role in human papillomavirus 16/HPV-16 endocytosis upon binding to cell surface receptor. {ECO:0000269|PubMed:24553111}.; FUNCTION: (Microbial infection) Plays a role in human cytomegalovirus entry into host cell by contributing to entry receptor binding, membrane fusion, or release of the capsid. {ECO:0000269|PubMed:27147745}.
uniprot
proteins
mass_dalton
28295
uniprot
proteins
mutagenesis
MUTAGEN 7; /note="K->R: Complete loss of RNF128-mediated ubiquitination; when associated with R-8 and R-17."; /evidence="ECO:0000269|PubMed:18713730"; MUTAGEN 8; /note="K->R: Complete loss of RNF128-mediated ubiquitination; when associated with R-7 and R-17."; /evidence="ECO:0000269|PubMed:18713730"; MUTAGEN 17; /note="K->R: Complete loss of RNF128-mediated ubiquitination; when associated with R-7 and R-8."; /evidence="ECO:0000269|PubMed:18713730"; MUTAGEN 159; /note="N->Q: Unable to modulate the glycosylation pattern of integrin ITGA3 subunit."; /evidence="ECO:0000269|PubMed:18852263
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. Palmitoylation by ZDHHC2 regulates CD151 expression, association with other tetraspanin family proteins and function in cell adhesion. {ECO:0000269|PubMed:18508921}.; PTM: Ubiquitinated by RNF128 on lysine residues present in the tetraspanin amino terminus via 'Lys-48'-linked ubiquitin leading to proteasomal degradation. {ECO:0000269|PubMed:18713730}.
uniprot
proteins
protein_family
Tetraspanin (TM4SF) family
uniprot
proteins
pubmed
11181065
uniprot
proteins
pubmed
11907260
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15265795
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17045834
uniprot
proteins
pubmed
18508921
uniprot
proteins
pubmed
18713730
uniprot
proteins
pubmed
18852263
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22843693
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24553111
uniprot
proteins
pubmed
24723389
uniprot
proteins
pubmed
27147745
uniprot
proteins
pubmed
27993971
uniprot
proteins
pubmed
31488507
uniprot
proteins
pubmed
32978478
uniprot
proteins
pubmed
35067832
uniprot
proteins
pubmed
7632941
uniprot
proteins
pubmed
8627808
uniprot
proteins
sequence_length
253
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22843693, ECO:0000269|PubMed:24723389}; Multi-pass membrane protein. Note=Relocalizes to the immune synapse in T-cells upon activation. {ECO:0000269|PubMed:24723389}.
uniprot
proteins
transmembrane_region
TRANSMEM 19..39; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 58..78; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 92..112; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 222..242; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins