Tbc1d23
entrez
67581
canonical
uniprot
Q8K0F1
canonical
ensembl
ENSMUSG00000022749
resolver
ensp
ENSMUSP00000023431
resolver
ensp
ENSMUSP00000154535
resolver
enst
ENSMUST00000226586
resolver
genesymbol
Tbc1d23
resolver
uniprot
A0A2I3BRD1
resolver
uniprot
Q3TAW9
resolver
uniprot
Q8VE48
resolver
uniprot_entry
A0A2I3BRD1_MOUSE
resolver
uniprot_entry
TBC23_MOUSE
resolver
uniprot_sec
Q3TAW9
resolver
uniprot_sec
Q8VE48
resolver
amino_acid_sequence
MAEGEELLPLSTSGGDSWEKDLEEALEAGGCDLETLRNIIQGRPLPAELRAKVWKIALNVAGKGDSLASWDGILDLPEQNTIHKDCLEFIEQLSVPEEKAAELLLDIESVITFYCKSRSVKYSTSLSWIHLLKPLICLQLPRSDLYNCFYAVMNKYIPRDCSLKGRPFHLFRLLIQYHEPELCSFLDTKKITPDSYALNWLGSLFAHYCSTEVTQAIWDGYLQQADPFFIYFLMLIILVNTKEVILAQESDSKEEVIRFLESTPASLNLEDIEDLFSLAQYYCSKTPASFRKDNHHLFGSTLLGIKDDEADLSQALCLAVSVSEILQANQLQGEGVRFFVVDCRPAEQYNAGHLATAFHLDSDLMLQNPSEFAQSVKSLLEAQKQSIESGSIAGGEHLCFMGSGREEEDMYMNMVLAHFLQKNKEYVSIASGGFMALQQHLADINVEGPESGYGHWIASTSGSRGSISSVDGESCNGSNDRGMKSLVSKMTVALKTKSVTVREKVISFIENSSTPVDRHVSSSDRVGKPYRGVKPVFSIGDEEEYDTDEIDSSSMSDDDRKEVVNIQTWINKPDIKHHFPCKEVKESGHMFPSHLLVTATHMYCLREILSRKGLAYIQSRQALNSVVKITSKKKHPELITFKYGNSSASGIEILAIERYLIPNAGDATRAIKQQIMKVLDALES
uniprot
proteins
function
FUNCTION: Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, including GOLGA1 and GOLGA4, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (PubMed:29084197). Together with WDR11 complex facilitates the golgin-mediated capture of vesicles generated using AP-1 (By similarity). Plays a role in brain development, including in cortical neuron positioning. May also be important for neurite outgrowth, possibly through its involvement in membrane trafficking and cargo delivery, 2 processes which are essential for axonal and dendritic growth (PubMed:28823707). May act as a general inhibitor of innate immunity signaling, strongly inhibiting multiple TLR and dectin/CLEC7A-signaling pathways. Does not alter initial activation events, but instead affects maintenance of inflammatory gene expression several hours after bacterial lipopolysaccharide (LPS) challenge (PubMed:22312129). {ECO:0000250|UniProtKB:Q9NUY8, ECO:0000269|PubMed:22312129, ECO:0000269|PubMed:28823707, ECO:0000269|PubMed:29084197}.
uniprot
proteins
mass_dalton
76426
uniprot
proteins
mutagenesis
MUTAGEN 50; /note="R->A: Fails to inhibit LPS-induced cytokine production."; /evidence="ECO:0000269|PubMed:22312129
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22312129
uniprot
proteins
pubmed
28823707
uniprot
proteins
pubmed
29084197
uniprot
proteins
sequence_length
684
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:29084197}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q9NUY8}. Note=Localization to the trans-Golgi (TGN) is regulated by ARL1 and ARL5B/ARL8. ARL1 increases Golgi localization, while ARL5B decreases it. Recruitment to the trans-Golgi network requires the presence of GOLGA1 and GOLGA4, but not that of FAM91A1 (By similarity). Recruited on AP-1-derived vesicles by WDR11 complex (By similarity). {ECO:0000250|UniProtKB:Q9NUY8}.
uniprot
proteins