227707
entrez
227707
canonical
uniprot
Q3TQI7
canonical
ensembl
ENSMUSG00000026851
resolver
ensp
ENSMUSP00000028205
resolver
ensp
ENSMUSP00000352016
resolver
enst
ENSMUST00000028205
resolver
uniprot
Q99JW3
resolver
uniprot_entry
TLS1_MOUSE
resolver
uniprot_sec
Q99JW3
resolver
amino_acid_sequence
MRITGKTFRRRRADSESEEDEQESEEVRLKLEETREVQNLRKRPNGVSAAALLVGEKVQEETTLVDDPFQMATGGMVDMKKLKERGKDKVSEEEDLHLGTSFSAETNRRDEDADMMKYIETELKKRKGIVEQEEQKAKPKNAEDCLYELPENIRVSSAKKTEEMLSNQMLSGIPEVDLGIDAKIKNIISTEDAKARLLAEQQNKKKDSETSFVPTNMAVNYVQHNRFYHEELNAPIRRNKEEPKARPLRVGDTEKPEPERSPPNRKRPANEKATDDYHYEKFKKMNRRY
uniprot
proteins
function
FUNCTION: Plays a role in pre-mRNA splicing by promoting usage of the upstream 3'-splice site at alternative NAGNAG splice sites; these are sites featuring alternative acceptor motifs separated by only a few nucleotides (By similarity). May also modulate exon inclusion events (By similarity). PPlays a role in spliceosomal remodeling by displacing WBP4 from SNRNP200 and may act to inhibit SNRNP200 helicase activity (By similarity). Binds U5 snRNA (By similarity). Required for proper chromosome segregation (By similarity). Not required for splicing of shelterin components (By similarity). {ECO:0000250|UniProtKB:Q9NZ63}.
uniprot
proteins
mass_dalton
33544
uniprot
proteins
protein_family
TLS1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
289
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NZ63}. Chromosome, centromere {ECO:0000250|UniProtKB:Q9NZ63}. Note=Dispersed throughout the nucleus during interphase (By similarity). Colocalizes with microtubule attachment sites at centromeres following mitotic checkpoint activation (By similarity). {ECO:0000250|UniProtKB:Q9NZ63}.
uniprot
proteins