ERP44
entrez
23071
canonical
uniprot
Q9BS26
canonical
ensembl
ENSG00000023318
resolver
ensp
ENSP00000262455
resolver
enst
ENST00000262455
resolver
genesymbol
ERP44
resolver
genesymbol_syn
KIAA0573
resolver
genesymbol_syn
TXNDC4
resolver
hgnc
HGNC:18311
resolver
uniprot
A0A384MEE7
resolver
uniprot
O60319
resolver
uniprot
Q4VXC1
resolver
uniprot
Q5VWZ7
resolver
uniprot
Q6UW14
resolver
uniprot
Q8WX67
resolver
uniprot_entry
A0A384MEE7_HUMAN
resolver
uniprot_entry
ERP44_HUMAN
resolver
uniprot_sec
O60319
resolver
uniprot_sec
Q4VXC1
resolver
uniprot_sec
Q5VWZ7
resolver
uniprot_sec
Q6UW14
resolver
uniprot_sec
Q8WX67
resolver
amino_acid_sequence
MHPAVFLSLPDLRCSLLLLVTWVFTPVTTEITSLDTENIDEILNNADVALVNFYADWCRFSQMLHPIFEEASDVIKEEFPNENQVVFARVDCDQHSDIAQRYRISKYPTLKLFRNGMMMKREYRGQRSVKALADYIRQQKSDPIQEIRDLAEITTLDRSKRNIIGYFEQKDSDNYRVFERVANILHDDCAFLSAFGDVSKPERYSGDNIIYKPPGHSAPDMVYLGAMTNFDVTYNWIQDKCVPLVREITFENGEELTEEGLPFLILFHMKEDTESLEIFQNEVARQLISEKGTINFLHADCDKFRHPLLHIQKTPADCPVIAIDSFRHMYVFGDFKDVLIPGKLKQFVFDLHSGKLHREFHHGPDPTDTAPGEQAQDVASSPPESSFQKLAPSEYRYTLLRDRDEL
uniprot
proteins
function
FUNCTION: Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif (PubMed:11847130, PubMed:14517240). Inhibits the calcium channel activity of ITPR1 (PubMed:15652484). May have a role in the control of oxidative protein folding in the endoplasmic reticulum (PubMed:11847130, PubMed:14517240, PubMed:29858230). Required to retain ERO1A and ERO1B in the endoplasmic reticulum (PubMed:11847130, PubMed:29858230). {ECO:0000269|PubMed:11847130, ECO:0000269|PubMed:14517240, ECO:0000269|PubMed:15652484, ECO:0000269|PubMed:29858230}.
uniprot
proteins
mass_dalton
46971
uniprot
proteins
pubmed
11847130
uniprot
proteins
pubmed
11921445
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14517240
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15652484
uniprot
proteins
pubmed
18552768
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29858230
uniprot
proteins
pubmed
9628581
uniprot
proteins
sequence_length
406
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000269|PubMed:11847130, ECO:0000269|PubMed:15652484}.
uniprot
proteins