Eeig1
entrez
98952
canonical
uniprot
Q78T81
canonical
ensembl
ENSMUSG00000039157
resolver
ensp
ENSMUSP00000044731
resolver
enst
ENSMUST00000048375
resolver
genesymbol
Eeig1
resolver
genesymbol_syn
Fam102a
resolver
uniprot
A0A158RFU0
resolver
uniprot
Q8K2K5
resolver
uniprot_entry
A0A158RFU0_MOUSE
resolver
uniprot_entry
EEIG1_MOUSE
resolver
uniprot_sec
Q8K2K5
resolver
amino_acid_sequence
MAFLMKKKKFKFQTTFTLEELTAVPFVNGVLFCKVRLLDGGDFVSLSSREEVQENCVRWRKRFTFVCKMSANPATGLLDPCIFRVSVRKELKGGKAYSKLGFTDLNLAEFAGSGSTVRCCLLEGYDTKNTRQDNSILKVTIGMFLLSGDPCFKTPPSTAKSISIPGQDSSLQLTCKGGGTSSGGSSSTNSLTGSRPPKTRPTILGSGLPEEPDQSLSSPEEVFHSGHSRNSSYASQQSKLSGYSTEHSRSSSLSDLTHRRNTSTSSSASGGLSMAVEGPEGMEREHRPSEKPPRPPEKPPRPPRPLHLSDRSFRRKKDSVESHPTWVDDTRIDADDIVEKIMQSQDFTDGSNTEDSNLRLFVSRDGSTTLSGIQLGNRVSSGVYEPVVIESH
uniprot
proteins
function
FUNCTION: Key component of TNFSF11/RANKL- and TNF-induced osteoclastogenesis pathways, thereby mediates bone resorption in pathological bone loss conditions (PubMed:23478294, PubMed:32741026). Required for TNFSF11/RANKL-induced osteoclastogenesis via its interaction with TNFRSF11A/RANK, thereby facilitates the downstream transcription of NFATC1 and activation of PLCG2 (PubMed:23478294). Facilitates recruitment of the transcriptional repressor PRDM1/BLIMP1 to the promoter of the anti-osteoclastogenesis gene IRF8, thereby resulting in transcription of osteoclast differentiation factors (PubMed:32741026). May play a role in estrogen action (By similarity). {ECO:0000250|UniProtKB:Q5T9C2, ECO:0000269|PubMed:23478294, ECO:0000269|PubMed:32741026}.
uniprot
proteins
mass_dalton
42830
uniprot
proteins
protein_family
EEIG family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23478294
uniprot
proteins
pubmed
32741026
uniprot
proteins
sequence_length
392
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:32741026}. Cytoplasm {ECO:0000269|PubMed:23478294, ECO:0000269|PubMed:32741026}. Membrane raft {ECO:0000269|PubMed:23478294}.
uniprot
proteins