Dctd
entrez
290741
canonical
uniprot
Q5M9G0
canonical
ensembl
ENSRNOG00000013215
resolver
ensp
ENSRNOP00000017670
resolver
ensp
ENSRNOP00000056214
resolver
enst
ENSRNOT00000017670
resolver
enst
ENSRNOT00000059459
resolver
genesymbol
Dctd
resolver
uniprot
A0A0A0MXX3
resolver
uniprot
D3ZXS5
resolver
uniprot_entry
A0A0A0MXX3_RAT
resolver
uniprot_entry
D3ZXS5_RAT
resolver
uniprot_entry
DCTD_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Allosteric enzyme whose activity is greatly influenced by the end products of its metabolic pathway, dCTP and dTTP. {ECO:0000250|UniProtKB:P32321}.
uniprot
proteins
amino_acid_sequence
MSDISCKKRDDYLEWPEYFMAVAFLSAQRSKDPSSQVGACIVNTENKIVGIGYNGMPNGCSDDLLPWRRTAENKLDTKYPYVCHAELNAIMNKNSADVKGCSMYVALFPCNECAKLIIQAGIKEVIFMSDKYHDSEETTAARLLFKLAGVTFRKFTPKYSKIVIDFDSINSRPSQKPQ
uniprot
proteins
ec_number
3.5.4.12
uniprot
proteins
function
FUNCTION: Catalyzes the deamination of dCMP to dUMP, providing the nucleoside monophosphate substrate for the thymidylate synthase/TYMS. Also, part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate). Catalyzes the first step in that pathway, the deamination of 5-hydroxymethyl-dCMP (hmdCMP). {ECO:0000250|UniProtKB:P32321}.
uniprot
proteins
mass_dalton
20059
uniprot
proteins
protein_family
Cytidine and deoxycytidylate deaminase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
178
uniprot
proteins