Plaa
entrez
116645
canonical
uniprot
P54319
canonical
ensembl
ENSRNOG00000007753
resolver
ensembl
ENSRNOG00055006795
resolver
ensembl
ENSRNOG00060013578
resolver
ensembl
ENSRNOG00065017699
resolver
ensp
ENSRNOP00000085067
resolver
ensp
ENSRNOP00055008712
resolver
ensp
ENSRNOP00060018381
resolver
ensp
ENSRNOP00065023533
resolver
enst
ENSRNOT00000094582
resolver
enst
ENSRNOT00055011131
resolver
enst
ENSRNOT00060023182
resolver
enst
ENSRNOT00065029619
resolver
genesymbol
Plaa
resolver
genesymbol_syn
Plap
resolver
uniprot
A0A8I6A2M3
resolver
uniprot_entry
A0A8I6A2M3_RAT
resolver
uniprot_entry
PLAP_RAT
resolver
amino_acid_sequence
MASGAARYRLSCSLPGHELDVRGLVCCLYPPGAFVSVSRDRTTRLWAPDSPNRGFTEMHCMSGHSNFVSCVCIIPSSDIYPHGLIATGGNDHNICIFSLDSPMPLYILKGHKDTVCSLSSGKFGTLLSGSWDTTAKVWLNDKCMMTLQGHTAAVWAVKILPEQGLMLTGSADKTIKLWKAGRCERTFSGHEDCVRGLAILSETEFLSCANDASIRRWQITGECLGVYYGHTNYIYSISVFPNCRDFVTTAEDRSLRIWKHGECAQTIRLPAQSIWCCCVLDNGDIVVGASDGIIRVFTEADERTASAEEIKAFERELSQATIDSKTGDLGDINAEQLPGREHLNEPGTREGQTRLIRDGERVEAYQWSVSDGRWIKIGDVVGSSGANQQTSGKVLYEGKEFDYVFSIDVNEGGPSYKLPYNVSDDPWLVAYNFLQKNDLNPMFLDQVAKFIIDNTKGQTLGLGNTSFSDPFTGGGRYVPGTSGPSNTVQTADPFTGAGRYMPGSAGMDTTMAGVDPFTGNSAYRSAASKTVNIYFPKKEALTFDQANPTQILGKLKELNGSAPEEKKLTEDDLVLLEKILSLICGNASEKPTAQQLQVLWKAINWPEDIVFPALDILRLSIKHPSVNENFCNEKEGDQFSSHLINLLNPKGKPANQLLALRTFCNCFVSQAGQKLMMSQRESLMSHAIELKSGSNKNIHIALATLTLNYSVCFHKDHNIEGKAQCLSVISTILEVVQDLEATFRLLVALGTLISDDSNAIQLAKSLGVDSQIKKYASVSEPAKVSECCRLILNLL
uniprot
proteins
function
FUNCTION: Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (By similarity). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (By similarity). Plays a role in cerebellar Purkinje cell development. Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (By similarity). {ECO:0000250|UniProtKB:P27612, ECO:0000250|UniProtKB:Q9Y263}.
uniprot
proteins
mass_dalton
87084
uniprot
proteins
protein_family
WD repeat PLAP family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7665086
uniprot
proteins
sequence_length
795
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P27612}. Cytoplasm {ECO:0000250|UniProtKB:P27612}. Synapse {ECO:0000250|UniProtKB:P27612}. Note=Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains. {ECO:0000250|UniProtKB:Q9Y263}.
uniprot
proteins