Gucy2e
entrez
14919
canonical
uniprot
P52785
canonical
ensembl
ENSMUSG00000020890
resolver
ensp
ENSMUSP00000021259
resolver
ensp
ENSMUSP00000104304
resolver
ensp
ENSMUSP00000104305
resolver
enst
ENSMUST00000021259
resolver
enst
ENSMUST00000108664
resolver
enst
ENSMUST00000108665
resolver
genesymbol
Gucy2e
resolver
genesymbol_syn
Guc2e
resolver
uniprot
B1ASX7
resolver
uniprot_entry
GUC2E_MOUSE
resolver
uniprot_sec
B1ASX7
resolver
activity_regulation
ACTIVITY REGULATION: Activated by GUCA1A when free calcium ions concentration is low, and inhibited by GUCA1A when free calcium ions concentration is high (PubMed:21598940). Negatively regulated by RD3; RD3 inhibits the basal and GUCA1A-stimulated guanylate cyclase activity (By similarity). {ECO:0000250|UniProtKB:Q02846, ECO:0000269|PubMed:21598940}.
uniprot
proteins
amino_acid_sequence
MSAWLLPAGGLPGAGFCVPARQSPSSFSRVLRWPRPGLPGLLLLLLLPSPSALSAVFKVGVLGPWACDPIFARARPDLAARLAANRLNRDFALDGGPRFEVALLPEPCLTPGSLGAVSSALSRVSGLVGPVNPAACRPAELLAQEAGVALVPWGCPGTRAAGTTAPAVTPAADALYVLLRAFRWARVALITAPQDLWVEAGRALSTALRARGLPVALVTSMETSDRSGAREALGRIRDGPRVRVVIMVMHSVLLGGEEQRYLLEAAEELALTDGSLVFLPFDTLHYALSPGPEALAAFVNSSQLRRAHDAVLTLTRRCPPGGSVQDSLRRAQEHQELPLDLNLKQVSPLFGTIYDAVFLLAGGVKRARTAVGGGWVSGASVARQVREAQVSGFCGVLGRTEEPSFVLLDTDASGEQLFATHLLDPVLGSLRSAGTPMHFPRGGPAPGPDPSCWFDPDVICNGGVEPGLVFVGFLLVIGMGLTGAFLAHYLRHRLLHMQMASGPNKIILTLEDVTFLHPPGGSSRKVVQGSRSSLATRSASDIRSVPSQPQESTNVGLYEGDWVWLKKFPGEHHMAIRPATKTAFSKLRELRHENVALYLGLFLAGTADSPATPGEGILAVVSEHCARGSLHDLLAQREIKLDWMFKSSLLLDLIKGMRYLHHRGVAHGRLKSRNCVVDGRFVLKVTDHGHGRLLEAQRVLPEPPSAEDQLWTAPELLRDPSLERRGTLAGDVFSLAIIMQEVVCRSTPYAMLELTPEEVIQRVRSPPPLCRPLVSMDQAPMECIQLMTQCWAEHPELRPSMDLTFDLFKSINKGRKTNIIDSMLRMLEQYSSNLEDLIRERTEELEQEKQKTDRLLTQMLPPSVAEALKMGTSVEPEYFEEVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGAHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGSFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNMSTVRILRALDQGFQMECRGRTELKGKGIEDTYWLVGRLGFNKPIPKPPDLQPGASNHGISLQEIPPERRKKLEKARPGQFTGK
uniprot
proteins
ec_number
4.6.1.2
uniprot
proteins
function
FUNCTION: Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment (PubMed:21598940). May also participate in the trafficking of membrane-associated proteins to the photoreceptor outer segment membrane (PubMed:17255100). {ECO:0000269|PubMed:17255100, ECO:0000269|PubMed:21598940}.
uniprot
proteins
mass_dalton
120638
uniprot
proteins
post_translational_modification
PTM: There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds.
uniprot
proteins
protein_family
Adenylyl cyclase class-4/guanylyl cyclase family
uniprot
proteins
pubmed
17255100
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21598940
uniprot
proteins
pubmed
8838319
uniprot
proteins
sequence_length
1108
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Photoreceptor outer segment membrane {ECO:0000269|PubMed:21598940}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q02846}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 466..490; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins