Pycr2
entrez
364064
canonical
uniprot
Q6AY23
canonical
ensembl
ENSRNOG00000003267
resolver
ensembl
ENSRNOG00055012501
resolver
ensembl
ENSRNOG00060007077
resolver
ensembl
ENSRNOG00065017076
resolver
ensp
ENSRNOP00000104651
resolver
ensp
ENSRNOP00055017251
resolver
ensp
ENSRNOP00060008736
resolver
ensp
ENSRNOP00065022568
resolver
enst
ENSRNOT00000122204
resolver
enst
ENSRNOT00055021318
resolver
enst
ENSRNOT00060011624
resolver
enst
ENSRNOT00065028513
resolver
genesymbol
Pycr2
resolver
uniprot_entry
P5CR2_RAT
resolver
amino_acid_sequence
MSVGFIGAGQLACALARGFTAAGVLSAHKIIASSPEMDLPTVSALRKMGVNLTRSNKDTVRHSDVLFLAVKPHIIPFILDEIGADVQERHIVVSCAAGVTISSVEKKLMAFQPAPKVIRCMTNTPVVVREGATVYATGTHALVEDGKLLEQLMSSVGFCTEVEEDLIDAITGLSGSGPAYAFMALDALADGGVKMGVPRRLAVRLGAQALLGAAKMLLDSEDHPGQLKDNVCSPGGATIHALHFLESGGFRSLLINAVEASCIRTRELQSMADQEKVSPAALKKTLLDRVKLESPTVSTLAPPSSGKLLTRNPAQGSKRE
uniprot
proteins
ec_number
1.5.1.2
uniprot
proteins
function
FUNCTION: Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate to L-proline using NAD(P)H. At physiologic concentrations, has higher specific activity in the presence of NADH. Involved in cellular response to oxidative stress. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). {ECO:0000250|UniProtKB:Q96C36}.
uniprot
proteins
mass_dalton
33673
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by UBE4B, leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q96C36}.
uniprot
proteins
protein_family
Pyrroline-5-carboxylate reductase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
320
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q96C36}. Mitochondrion {ECO:0000250|UniProtKB:Q96C36}.
uniprot
proteins