Dsc2
entrez
13506
canonical
uniprot
P55292
canonical
ensembl
ENSMUSG00000024331
resolver
ensp
ENSMUSP00000042905
resolver
ensp
ENSMUSP00000074702
resolver
genesymbol
Dsc2
resolver
genesymbol_syn
Dsc3
resolver
uniprot
Q544V1
resolver
uniprot
Q64734
resolver
uniprot_entry
DSC2_MOUSE
resolver
uniprot_entry
Q544V1_MOUSE
resolver
uniprot_sec
Q64734
resolver
amino_acid_sequence
MAAVGSMRSGSPAFGLGHLLTLAILALASDACKEVVLQVPSELPAEKFVGRVNLMDCLKSADIVHLSDPDFQVLEDGSVYTTSSVVLSSGQRSFTIWLFSTDSQEEREISVHLEGPVEVLNKRPHTEKVLSRAKRRWAPIPCSMLENSLGPFPLFLQQIQSDTAQNYTIYYSIRGPGVDKEPLNLFYVERDTGNLYCTGRVDREQYESFELTAFATTPDGYTPEYPLPLLIKIEDENDNYPIFTQKLYSFTVQENSRIGSIVGEVCATDLDEPDTMHTRLRYSILEQSPSPPMLFTMHPSTGVITTTSAQLDRELIDKYQLLIKVQDMDGQYFGLHTTAKCIITIEDVNDNLPTFTRTTYVTSVEENTVNVEILRLTVQDKDLVNSPNWRANYTILKGNENGNFKIVTDPKTNEGILCVIKPLDYEERQQVTLQIGVVNEAPYTREASSKSPMSTATVTVTVTNQDEGPECIPPMQTVRIQENVPVGTRNDGYKAYDPETRSSSGIRYRKLSDPRGWVTVNEDSGSITIFRALDREAETVRNGIYNITVLALDADGRSCTGTLGIILEDVNDNGPFIPKQTVVICKATMSSAEIVAVDLDDPVNGPPFDFSLESSDSEVQRMWRLTRINDTAARLSYQNDPSFGSYAVPIRVTDRLGLSSVTTLNVLVCDCITESDCTLRSGERTGYADVRLGPWAILAILLGIALLFCILFTLVCSVSRASKQQKILPDDLAQQNLIVSNTEAPGDDKVYSTNGLTTQTMGASGQTAFTTMGTGVKSGGQETIEMVKGGQQTLDSRRGAGYHHHTLDPCRGGHVEVDNYRHTYSEWYNFIQPRLGDKVQFCHTDDNQKLAQDYVLTYNYEGKGSAAGSVGCCSDLQEEDGLEFLDHLEPKFRTLAEVCAKR
uniprot
proteins
function
FUNCTION: A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:33596089). Promotes timely incorporation of DSG2 into desmosome intercellular junctions and promotes interaction of desmosome cell junctions with intermediate filament cytokeratin, via modulation of DSP phosphorylation (By similarity). Plays an important role in desmosome-mediated maintenance of intestinal epithelial cell intercellular adhesion strength and barrier function (PubMed:33596089). Positively regulates wound healing of intestinal mucosa via promotion of epithelial cell migration, and also plays a role in mechanotransduction of force between intestinal epithelial cells and extracellular matrix (PubMed:31967937). May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. May promote p38MAPK signaling activation that facilitates keratinocyte migration (PubMed:26763450). {ECO:0000250|UniProtKB:Q02487, ECO:0000269|PubMed:26763450, ECO:0000269|PubMed:31967937, ECO:0000269|PubMed:33596089}.
uniprot
proteins
mass_dalton
99961
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26763450
uniprot
proteins
pubmed
27033150
uniprot
proteins
pubmed
31967937
uniprot
proteins
pubmed
33596089
uniprot
proteins
pubmed
38395410
uniprot
proteins
pubmed
7711832
uniprot
proteins
pubmed
7959727
uniprot
proteins
pubmed
9864371
uniprot
proteins
sequence_length
902
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q02487}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q02487}. Cell junction, desmosome {ECO:0000269|PubMed:38395410}.
uniprot
proteins
transmembrane_region
TRANSMEM 695..715; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins