DEFB118
entrez
117285
canonical
uniprot
Q96PH6
canonical
ensembl
ENSG00000131068
resolver
ensp
ENSP00000253381
resolver
enst
ENST00000253381
resolver
genesymbol
DEFB118
resolver
genesymbol_syn
C20orf63
resolver
genesymbol_syn
DEFB18
resolver
genesymbol_syn
ESC42
resolver
hgnc
HGNC:16196
resolver
uniprot
A0A384MTK2
resolver
uniprot
Q17RC4
resolver
uniprot
Q8N691
resolver
uniprot
Q9NUH0
resolver
uniprot_entry
A0A384MTK2_HUMAN
resolver
uniprot_entry
DB118_HUMAN
resolver
uniprot_sec
Q17RC4
resolver
uniprot_sec
Q8N691
resolver
uniprot_sec
Q9NUH0
resolver
amino_acid_sequence
MKLLLLALPMLVLLPQVIPAYSGEKKCWNRSGHCRKQCKDGEAVKDTCKNLRACCIPSNEDHRRVPATSPTPLSDSTPGIIDDILTVRFTTDYFEVSSKKDMVEESEAGRGTETSLPNVHHSS
uniprot
proteins
function
FUNCTION: Host defense peptide that exhibits antimicrobial activity against both Gram-negative bacteria, such as E.coli and S.typhimurium, and Gram-positive bacteria, such as S.aureus and B.subtilis (PubMed:15033915, PubMed:33224970). Inhibits cell adhesion of E.coli on intestinal epithelial enterocytes (PubMed:33224970). Causes rapid permeabilization of both the outer and inner membrane of E.coli, leading to morphological alterations on the bacterial surface (PubMed:15033915). Binds to bacterial lipopolysaccharides (LPS) with high affinity, and may thereby be involved in immunoregulation through LPS neutralization (PubMed:33181266). May contribute to epididymal innate immunity and protect the sperm against attack by microorganisms (PubMed:15033915). {ECO:0000269|PubMed:15033915, ECO:0000269|PubMed:33181266, ECO:0000269|PubMed:33224970}.
uniprot
proteins
mass_dalton
13614
uniprot
proteins
post_translational_modification
PTM: The three-dimensional structure formed by the three intramolecular disulfide bridges is indispensable for antimicrobial activity. {ECO:0000269|PubMed:15033915}.
uniprot
proteins
protein_family
Beta-defensin family
uniprot
proteins
pubmed
11564719
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
11854508
uniprot
proteins
pubmed
12600824
uniprot
proteins
pubmed
15033915
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
33181266
uniprot
proteins
pubmed
33224970
uniprot
proteins
sequence_length
123
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12600824}.
uniprot
proteins