Mylip
entrez
306825
canonical
uniprot
D3ZDI6
canonical
ensembl
ENSRNOG00000017579
resolver
ensp
ENSRNOP00000024021
resolver
enst
ENSRNOT00000024021
resolver
genesymbol
Mylip
resolver
uniprot_entry
MYLIP_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Can bind 1 iron ion per dimer. Iron binding seems to decrease LDLR degradation activity. {ECO:0000250|UniProtKB:Q8WY64}.
uniprot
proteins
amino_acid_sequence
MLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGIIEVDYFGLQFTGSKGESLWLNLRNRISQQMDGLAPYRLKLRVKFFVEPHLILQEQTRHIFFLHIKESLLAGHLQCSPEQAVELSALLAQTKFGDYNQNTAQYSYEDLCEKELSSSTLNSIVGKHKELEGISQASAEYQVLQIVSAMENYGIEWHAVRDSEGQKLLIGVGPEGISICKEDFSPINRIAYPVVQMATQSGKNVYLTVTKESGNSIVLLFKMISTRAASGLYRAITETHAFYRCDTVTSAVMMQYSRDLKGHLASLFLNENINLGKKYVFDIKRTSKEVYDHARRALYNAGVVDLVSRNDQSPPSSPLKSSDSSMSCSSCEGLSCQQTRVLQEKLRKLKEAMLCMVCCEEEINSTFCPCGHTVCCESCAAQLQSCPVCRSRVEHVQHVYLPTHTSLLNLTVI
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR. {ECO:0000250|UniProtKB:Q8BM54}.
uniprot
proteins
mass_dalton
49890
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated. {ECO:0000250}.
uniprot
proteins
pubmed
10593918
uniprot
proteins
pubmed
11162443
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
445
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8WY64}. Cell membrane {ECO:0000250|UniProtKB:Q8WY64}; Peripheral membrane protein.
uniprot
proteins