Cd14
entrez
12475
canonical
uniprot
P10810
canonical
ensembl
ENSMUSG00000051439
resolver
ensp
ENSMUSP00000056669
resolver
enst
ENSMUST00000061829
resolver
genesymbol
Cd14
resolver
uniprot
Q3UB18
resolver
uniprot
Q3UE54
resolver
uniprot
Q4FJP7
resolver
uniprot_entry
CD14_MOUSE
resolver
uniprot_entry
Q3UB18_MOUSE
resolver
uniprot_entry
Q3UE54_MOUSE
resolver
uniprot_entry
Q4FJP7_MOUSE
resolver
amino_acid_sequence
MERVLGLLLLLLVHASPAPPEPCELDEESCSCNFSDPKPDWSSAFNCLGAADVELYGGGRSLEYLLKRVDTEADLGQFTDIIKSLSLKRLTVRAARIPSRILFGALRVLGISGLQELTLENLEVTGTAPPPLLEATGPDLNILNLRNVSWATRDAWLAELQQWLKPGLKVLSIAQAHSLNFSCEQVRVFPALSTLDLSDNPELGERGLISALCPLKFPTLQVLALRNAGMETPSGVCSALAAARVQLQGLDLSHNSLRDAAGAPSCDWPSQLNSLNLSFTGLKQVPKGLPAKLSVLDLSYNRLDRNPSPDELPQVGNLSLKGNPFLDSESHSEKFNSGVVTAGAPSSQAVALSGTLALLLGDRLFV
uniprot
proteins
function
FUNCTION: Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:16148141). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:15895089, PubMed:8612135). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (By similarity). Acts as an accessory receptor for M.tuberculosis lipoproteins LprA, LprG and LpqH, in conjunction with coreceptors TLR2 and TLR1. The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (By similarity). {ECO:0000250|UniProtKB:P08571, ECO:0000269|PubMed:15895089, ECO:0000269|PubMed:16148141, ECO:0000269|PubMed:19362712, ECO:0000269|PubMed:21821728, ECO:0000269|PubMed:8612135}.
uniprot
proteins
mass_dalton
39204
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15644310
uniprot
proteins
pubmed
15895089
uniprot
proteins
pubmed
16148141
uniprot
proteins
pubmed
1694207
uniprot
proteins
pubmed
19362712
uniprot
proteins
pubmed
21821728
uniprot
proteins
pubmed
24380872
uniprot
proteins
pubmed
2467257
uniprot
proteins
pubmed
2472171
uniprot
proteins
pubmed
8612135
uniprot
proteins
sequence_length
366
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21821728, ECO:0000269|PubMed:8612135}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P08571}. Secreted {ECO:0000250|UniProtKB:P08571}. Membrane raft {ECO:0000250|UniProtKB:P08571}. Golgi apparatus {ECO:0000250|UniProtKB:P08571}. Note=Soluble, secreted forms seem to exist. They may arise by cleavage of the GPI anchor. {ECO:0000250|UniProtKB:P08571}.
uniprot
proteins