MAP4K4
entrez
9448
canonical
uniprot
O95819
canonical
ensembl
ENSG00000071054
resolver
ensp
ENSP00000313644
resolver
ensp
ENSP00000314363
resolver
ensp
ENSP00000343658
resolver
ensp
ENSP00000392830
resolver
ensp
ENSP00000409720
resolver
ensp
ENSP00000486116
resolver
ensp
ENSP00000489579
resolver
ensp
ENSP00000572190
resolver
ensp
ENSP00000572191
resolver
ensp
ENSP00000572198
resolver
ensp
ENSP00000572199
resolver
ensp
ENSP00000603979
resolver
ensp
ENSP00000603980
resolver
ensp
ENSP00000603981
resolver
ensp
ENSP00000641142
resolver
ensp
ENSP00000641143
resolver
ensp
ENSP00000641148
resolver
enst
ENST00000324219
resolver
enst
ENST00000425019
resolver
genesymbol
HEL-S-31
resolver
genesymbol
MAP4K4
resolver
genesymbol_syn
HGK
resolver
genesymbol_syn
KIAA0687
resolver
genesymbol_syn
NIK
resolver
hgnc
HGNC:6866
resolver
uniprot
B7Z3V5
resolver
uniprot
E7EN19
resolver
uniprot
E7ESS2
resolver
uniprot
G5E948
resolver
uniprot
O75172
resolver
uniprot
Q9NST7
resolver
uniprot
V9HWH3
resolver
uniprot_entry
B7Z3V5_HUMAN
resolver
uniprot_entry
E7EN19_HUMAN
resolver
uniprot_entry
G5E948_HUMAN
resolver
uniprot_entry
M4K4_HUMAN
resolver
uniprot_entry
V9HWH3_HUMAN
resolver
uniprot_sec
E7ESS2
resolver
uniprot_sec
O75172
resolver
uniprot_sec
Q9NST7
resolver
amino_acid_sequence
MANDSPAKSLVDIDLSSLRDPAGIFELVEVVGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEEEEIKLEINMLKKYSHHRNIATYYGAFIKKSPPGHDDQLWLVMEFCGAGSITDLVKNTKGNTLKEDWIAYISREILRGLAHLHIHHVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDYRSDLWSCGITAIEMAEGAPPLCDMHPMRALFLIPRNPPPRLKSKKWSKKFFSFIEGCLVKNYMQRPSTEQLLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPADLTALAKELRAVEDVRPPHKVTDYSSSSEESGTTDEEDDDVEQEGADESTSGPEDTRAASSLNLSNGETESVKTMIVHDDVESEPAMTPSKEGTLIVRQTQSASSTLQKHKSSSSFTPFIDPRLLQISPSSGTTVTSVVGFSCDGMRPEAIRQDPTRKGSVVNVNPTNTRPQSDTPEIRKYKKRFNSEILCAALWGVNLLVGTESGLMLLDRSGQGKVYPLINRRRFQQMDVLEGLNVLVTISGKKDKLRVYYLSWLRNKILHNDPEVEKKQGWTTVGDLEGCVHYKVVKYERIKFLVIALKSSVEVYAWAPKPYHKFMAFKSFGELVHKPLLVDLTVEEGQRLKVIYGSCAGFHAVDVDSGSVYDIYLPTHIQCSIKPHAIIILPNTDGMELLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIRSNQTMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVYFMTLGRTSLLSW
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine kinase that plays a role in the response to environmental stress and cytokines such as TNF. Appears to act upstream of the JUN N-terminal pathway (PubMed:9890973). Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). Phosphorylates SMAD1 on Thr-322 (PubMed:21690388). {ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443, ECO:0000269|PubMed:9890973}.
uniprot
proteins
mass_dalton
142101
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
protein_family
STE20 subfamily
uniprot
proteins
pubmed
12387898
uniprot
proteins
pubmed
12612079
uniprot
proteins
pubmed
14966141
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21690388
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26437443
uniprot
proteins
pubmed
9734811
uniprot
proteins
pubmed
9890973
uniprot
proteins
sequence_length
1239
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14966141}.
uniprot
proteins