ST3GAL6
entrez
10402
canonical
uniprot
Q9Y274
canonical
ensembl
ENSG00000064225
resolver
ensp
ENSP00000265261
resolver
ensp
ENSP00000377717
resolver
ensp
ENSP00000417376
resolver
ensp
ENSP00000480884
resolver
ensp
ENSP00000551560
resolver
ensp
ENSP00000551581
resolver
ensp
ENSP00000551583
resolver
enst
ENST00000613264
resolver
genesymbol
ST3GAL6
resolver
genesymbol_syn
SIAT10
resolver
hgnc
HGNC:18080
resolver
uniprot
A0A087WXB8
resolver
uniprot
B2RCH2
resolver
uniprot
B3KMI1
resolver
uniprot
D3DN39
resolver
uniprot
F8W6U0
resolver
uniprot_entry
A0A087WXB8_HUMAN
resolver
uniprot_entry
SIA10_HUMAN
resolver
uniprot_sec
B2RCH2
resolver
uniprot_sec
B3KMI1
resolver
uniprot_sec
D3DN39
resolver
uniprot_sec
F8W6U0
resolver
amino_acid_sequence
MRGYLVAIFLSAVFLYYVLHCILWGTNVYWVAPVEMKRRNKIQPCLSKPAFASLLRFHQFHPFLCAADFRKIASLYGSDKFDLPYGMRTSAEYFRLALSKLQSCDLFDEFDNIPCKKCVVVGNGGVLKNKTLGEKIDSYDVIIRMNNGPVLGHEEEVGRRTTFRLFYPESVFSDPIHNDPNTTVILTAFKPHDLRWLLELLMGDKINTNGFWKKPALNLIYKPYQIRILDPFIIRTAAYELLHFPKVFPKNQKPKHPTTGIIAITLAFYICHEVHLAGFKYNFSDLKSPLHYYGNATMSLMNKNAYHNVTAEQLFLKDIIEKNLVINLTQD
uniprot
proteins
ec_number
2.4.3.6
uniprot
proteins
function
FUNCTION: Transfers the sialyl residue from CMP-N-acetyl-beta-neuraminate to the terminal galactose residue on sugar chains of glycoproteins and glycolipids (PubMed:10206952, PubMed:26692484). Its alpha-2,3-sialyltransferase activity is specific toward type II glycan chains (Galbeta1-4GlcNAc) on glycoproteins and glycolipids such as neolactosides nLc4Cer and nLc6Cer, whose sialyl-products serve as precursors for the Lewis X antigen (PubMed:10206952, PubMed:26692484). Critically involved in the synthesis of functional selectin ligands needed for neutrophil recruitment during inflammation and lymphocyte homing to the lymph nodes (By similarity). {ECO:0000250|UniProtKB:Q8VIB3, ECO:0000269|PubMed:10206952, ECO:0000269|PubMed:26692484}.
uniprot
proteins
mass_dalton
38214
uniprot
proteins
protein_family
Glycosyltransferase 29 family
uniprot
proteins
pubmed
10206952
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
26692484
uniprot
proteins
sequence_length
331
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..25; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins