Fyb1
entrez
23880
canonical
uniprot
O35601
canonical
ensembl
ENSMUSG00000022148
resolver
ensp
ENSMUSP00000087947
resolver
genesymbol
Fyb1
resolver
genesymbol_syn
Fyb
resolver
uniprot
B2RUR0
resolver
uniprot
Q9Z2H3
resolver
uniprot_entry
B2RUR0_MOUSE
resolver
uniprot_entry
FYB1_MOUSE
resolver
uniprot_sec
Q9Z2H3
resolver
amino_acid_sequence
MAKFNTGSNPTEEAATSSRPFKVAGQSSPSGIQSRKNLFDNQGNASPPAGPSSMPKFGTTKPPLAAKPTYEEKPEKEPKPPFLKPTGGSPRFGTQPNSVSRDPEVKVGFLKPVSPKPTSLTKEDSKPVVLRPPGNKLHNLNQESDLKTPGPKPGPAPPVPENELKPGFSKVAGAKSKFMPAAQDTDSKPRFPRHTFGQKPSLSTEDSQEENTSKNVPVQKGSPVQLGAKSKGAPFKPPKEDPEDKDHGAPSSPFPGVVLKPAASRGSPGLSKNFEEKKEDRKTDLAKNIFLNKLNQEEPARFPKAPSKLTAGTPWGQSQEKEGDKNSATPKQKALPPLSVLGPPPPKPNRPPNVDLTRFRKADSANSATKSQTPYSTTSLPPPPPTHPASQPPLPASHPAHPPVPSLPPRNIKPPLDLKHPINDENQDGVMHSDGTGNLEEEQESEGETYEDIDSSKERDKKREKEEKKRLELERKEQKEREKKEQELKKKFKLTGPIQVIHHAKACCDVKGGKNELSFKQGEDIEIIRITDNPEGKWLGRTARGSYGYIKTTAVEIDYDSLKRKKNSLNAVPPRLVEDDQDVYDDVAEQDAPNSHGQSGSGGMFPPPPTDDEIYDGIEEEDDDDGSVPQVDEKTNAWSWGILKMLKGKDDRKKSIREKPKVSESDNNEGSSLPSQHKQLDVGEEVYDDVDASDFPPPPAEMSQGMSVGRAKTEEKDPKKLKKQEKEEKDLRKKFKYDGEIRVLYSTKVASSLTSKKWGARDLQIKPGESLEVIQSTDDTKVLCRNEEGKYGYVLRSYLVDNDGEIYDDIADGCIYDND
uniprot
proteins
function
FUNCTION: Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells (PubMed:10497204, PubMed:9207119). May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton (By similarity). Modulates the expression of IL2 (PubMed:10497204, PubMed:9207119). Involved in platelet activation (PubMed:17003372). Prevents the degradation of SKAP1 and SKAP2 (By similarity). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (PubMed:12681493). {ECO:0000250|UniProtKB:O15117, ECO:0000269|PubMed:10497204, ECO:0000269|PubMed:12681493, ECO:0000269|PubMed:17003372, ECO:0000269|PubMed:9207119}.
uniprot
proteins
mass_dalton
90055
uniprot
proteins
post_translational_modification
PTM: T-cell receptor ligation leads to increased tyrosine phosphorylation.
uniprot
proteins
pubmed
10469599
uniprot
proteins
pubmed
10497204
uniprot
proteins
pubmed
11207596
uniprot
proteins
pubmed
12681493
uniprot
proteins
pubmed
17003372
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21881001
uniprot
proteins
pubmed
9207119
uniprot
proteins
sequence_length
819
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O15117}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768}. Cell junction {ECO:0000269|PubMed:21881001}. Note=Colocalizes with TMEM47 at cell-cell contacts in podocytes. {ECO:0000269|PubMed:21881001}.
uniprot
proteins