Avpr2
entrez
25108
canonical
uniprot
Q00788
canonical
ensembl
ENSRNOG00000059862
resolver
ensembl
ENSRNOG00055024972
resolver
ensembl
ENSRNOG00060006538
resolver
ensembl
ENSRNOG00065014794
resolver
ensp
ENSRNOP00000071931
resolver
ensp
ENSRNOP00055035125
resolver
ensp
ENSRNOP00060007935
resolver
ensp
ENSRNOP00065019085
resolver
enst
ENSRNOT00000091495
resolver
enst
ENSRNOT00055043038
resolver
enst
ENSRNOT00060010704
resolver
enst
ENSRNOT00065024453
resolver
genesymbol
Avpr2
resolver
uniprot
Q53ZC4
resolver
uniprot_entry
V2R_RAT
resolver
uniprot_sec
Q53ZC4
resolver
amino_acid_sequence
MLLVSTVSAVPGLFSPPSSPSNSSQEELLDDRDPLLVRAELALLSTIFVAVALSNGLVLGALIRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLVPGPSERAGRRRRGRRTGSPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPLERPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCAQRHTTHSLGPQDESCATASSSLMKDTPS
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for arginine vasopressin, an antidiuretic that promotes renal water reabsorption (PubMed:1534150). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (cAMP) (By similarity). AVPR2 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (By similarity). {ECO:0000250|UniProtKB:P30518, ECO:0000269|PubMed:1534150}.
uniprot
proteins
mass_dalton
40749
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of the P-X-P-P motif promotes association with beta-arrestin ARRB2, leading to receptor desensitization and negative regulation of G protein-coupled receptor signaling. {ECO:0000250|UniProtKB:P30518}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Vasopressin/oxytocin receptor subfamily
uniprot
proteins
pubmed
1534150
uniprot
proteins
pubmed
7708485
uniprot
proteins
sequence_length
371
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1534150}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P30518}.
uniprot
proteins
transmembrane_region
TRANSMEM 39..63; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 78..98; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 114..135; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 160..180; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 201..220; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 272..293; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 309..328; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins