MLF1
entrez
4291
canonical
uniprot
P58340
canonical
ensembl
ENSG00000178053
resolver
ensp
ENSP00000348157
resolver
ensp
ENSP00000352025
resolver
ensp
ENSP00000417278
resolver
ensp
ENSP00000417777
resolver
ensp
ENSP00000417835
resolver
ensp
ENSP00000418595
resolver
ensp
ENSP00000419636
resolver
ensp
ENSP00000419637
resolver
ensp
ENSP00000420134
resolver
ensp
ENSP00000420410
resolver
ensp
ENSP00000483337
resolver
ensp
ENSP00000498363
resolver
ensp
ENSP00000498915
resolver
ensp
ENSP00000499162
resolver
ensp
ENSP00000796855
resolver
enst
ENST00000466246
resolver
enst
ENST00000491767
resolver
enst
ENST00000498592
resolver
enst
ENST00000619577
resolver
enst
ENST00000650753
resolver
genesymbol
MLF1
resolver
hgnc
HGNC:7125
resolver
uniprot
A0A0S2Z4A4
resolver
uniprot
A0A0S2Z4U8
resolver
uniprot
A0A140VKD2
resolver
uniprot
A0A494C175
resolver
uniprot
A0A499FJ64
resolver
uniprot
A0ACM8QBN2
resolver
uniprot
B2RD48
resolver
uniprot
C9J3M3
resolver
uniprot
C9JNE5
resolver
uniprot
C9K0D4
resolver
uniprot
E9PEU9
resolver
uniprot
Q2TLE3
resolver
uniprot
Q2TLE4
resolver
uniprot
Q2TLE5
resolver
uniprot
Q8N8F8
resolver
uniprot
Q96MH1
resolver
uniprot_entry
A0A0S2Z4A4_HUMAN
resolver
uniprot_entry
A0A0S2Z4U8_HUMAN
resolver
uniprot_entry
A0A140VKD2_HUMAN
resolver
uniprot_entry
A0A494C175_HUMAN
resolver
uniprot_entry
A0A499FJ64_HUMAN
resolver
uniprot_entry
A0ACM8QBN2_HUMAN
resolver
uniprot_entry
B2RD48_HUMAN
resolver
uniprot_entry
C9JNE5_HUMAN
resolver
uniprot_entry
C9K0D4_HUMAN
resolver
uniprot_entry
MLF1_HUMAN
resolver
uniprot_entry
Q2TLE4_HUMAN
resolver
uniprot_sec
C9J3M3
resolver
uniprot_sec
E9PEU9
resolver
uniprot_sec
Q2TLE3
resolver
uniprot_sec
Q2TLE5
resolver
uniprot_sec
Q8N8F8
resolver
uniprot_sec
Q96MH1
resolver
amino_acid_sequence
MFRMLNSSFEDDPFFSESILAHRENMRQMIRSFSEPFGRDLLSISDGRGRAHNRRGHNDGEDSLTHTDVSSFQTMDQMVSNMRNYMQKLERNFGQLSVDPNGHSFCSSSVMTYSKIGDEPPKVFQASTQTRRAPGGIKETRKAMRDSDSGLEKMAIGHHIHDRAHVIKKSKNKKTGDEEVNQEFINMNESDAHAFDEEWQSEVLKYKPGRHNLGNTRMRSVGHENPGSRELKRREKPQQSPAIEHGRRSNVLGDKLHIKGSSVKSNKK
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving MLF1 is a cause of myelodysplastic syndrome (MDS). Translocation t(3;5)(q25.1;q34) with NPM1/NPM. {ECO:0000269|PubMed:8570204}.
uniprot
proteins
function
FUNCTION: Involved in lineage commitment of primary hemopoietic progenitors by restricting erythroid formation and enhancing myeloid formation. Interferes with erythropoietin-induced erythroid terminal differentiation by preventing cells from exiting the cell cycle through suppression of CDKN1B/p27Kip1 levels. Suppresses COP1 activity via CSN3 which activates p53 and induces cell cycle arrest. Binds DNA and affects the expression of a number of genes so may function as a transcription factor in the nucleus. {ECO:0000269|PubMed:15861129}.
uniprot
proteins
mass_dalton
30627
uniprot
proteins
post_translational_modification
PTM: Phosphorylation is required for binding to YWHAZ. {ECO:0000250}.
uniprot
proteins
protein_family
MLF family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15116101
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15861129
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
22151054
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
8570204
uniprot
proteins
sequence_length
268
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9QWV4}. Nucleus {ECO:0000250|UniProtKB:Q9QWV4}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9QWV4}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9QWV4}. Note=Shuttles between the cytoplasm and nucleus. {ECO:0000250|UniProtKB:Q9QWV4}.
uniprot
proteins