Ptgdr2
entrez
14764
canonical
uniprot
Q9Z2J6
canonical
ensembl
ENSMUSG00000034117
resolver
ensp
ENSMUSP00000036159
resolver
enst
ENSMUST00000037261
resolver
genesymbol
Ptgdr2
resolver
genesymbol_syn
Crth2
resolver
genesymbol_syn
Gpr44
resolver
uniprot
Q54A00
resolver
uniprot_entry
PD2R2_MOUSE
resolver
uniprot_sec
Q54A00
resolver
amino_acid_sequence
MANVTLKPLCPLLEEMVQLPNHSNSSLRYIDHVSVLLHGLASLLGLVENGLILFVVGCRMRQTVVTTWVLHLALSDLLAAASLPFFTYFLAVGHSWELGTTFCKLHSSVFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAVAHRVCLMLWALAVLNTIPYFVFRDTIPRLDGRIMCYYNLLLWNPGPDRDTTCDYRQKALAVSKFLLAFMVPLAIIASSHVAVSLRLHHRGRQRTGRFVRLVAAIVVAFVLCWGPYHIFSLLEARAHSVTTLRQLASRGLPFVTSLAFFNSVVNPLLYVFTCPDMLYKLRRSLRAVLESVLVEDSDQSGGLRNRRRRASSTATPASTLLLADRIPQLRPTRLIGWMRRGSAEVPQRV
uniprot
proteins
function
FUNCTION: Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses (By similarity). {ECO:0000250, ECO:0000269|PubMed:12878180, ECO:0000269|PubMed:16888024}.
uniprot
proteins
mass_dalton
42950
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12878180
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16888024
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9931443
uniprot
proteins
sequence_length
382
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Internalized receptors colocalized with RAB11A. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 33..55; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 67..88; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 106..126; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 146..167; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 210..230; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 247..268; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 288..307; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins