Fras1
entrez
231470
canonical
uniprot
Q80T14
canonical
ensembl
ENSMUSG00000034687
resolver
ensp
ENSMUSP00000043250
resolver
enst
ENSMUST00000036019
resolver
genesymbol
Fras1
resolver
genesymbol_syn
Kiaa1500
resolver
uniprot
E9QPG9
resolver
uniprot
Q80TC7
resolver
uniprot
Q811H8
resolver
uniprot
Q8BPZ4
resolver
uniprot_entry
FRAS1_MOUSE
resolver
uniprot_sec
E9QPG9
resolver
uniprot_sec
Q80TC7
resolver
uniprot_sec
Q811H8
resolver
uniprot_sec
Q8BPZ4
resolver
amino_acid_sequence
MGVLKAWLGVALALAEFAVLPNCEGACLYQGSFLADATIWKPDSCQNCRCHGDIVICKPVVCKNPRCAFEKGEVLWIAPNQCCPQCAPRTPGSCHHEGKIHEHGTEWASAPCTVCSCTHGEVRCSHQQCTPLSCGPQELEFLAEGRCCPICVGTGKPCSYDGHVFQDGEDWQLSRCAKCVCRNGLTQCFAAQCQPLFCNQDEIVVRVPGKCCSQCSARSCSTAGQVYEHGEQWKEDACTLCMCDQGQVRCHKQVCPPLRCAKGQGRARHHGQCCEECATPDRSCSSGGVLRYQDEMWKGSACEFCMCDQGQVTCQTGECAKVACALGEELVHLEGKCCPECISRNGYCIYEQKAETMSSSAREIKHVPDGEKWEEGPCKLCECREAQVTCYEPSCPPCPVATLALVVKGQCCPDCTPVHCHPDCLTCSHSPDHCDLCQDPTKLLQNGRCVHSCGLGFYQAGSLCLACQPQCSTCTNGLECSSCLPPLLMQQGQCVSTCGDGFYQDHHSCAVCHESCAGCWGPTEKHCMACRDPLQVLRDSSCENTCGNGFYNRQGTCVACDQSCKSCGPSSPRCLSCAEKTILHDGKCISECPHGYYADSTGSCKVCHSSCASCSGPTAAHCIACIHPQTLRQGHCLPSCGEGFYPDHGICEACHASCHTCVGPQPSHCTQCKKPEAGLLVEQHSGENVPYGKCVSRCGTHFYLESTGLCEVCHPSCLTCEGKSPHNCTGCESTHALLAGCCVSQCPETHFNLEGTCTECHPSCRQCHGPLESDCVSCHPHLTLTSGHCKTSCKEEQFLNLVGYCADCHPLCQHCVANLQDTGSICLKCQHARHLLLGDHCVPECPPGHYKERGTCKTCHSSCRSCQNGGPFSCSSCDTGLVLTHIGTCSTACFPGHYLDDNQVCQPCNRHCRSCDSQGSCTSCRDPSKVLLFGECQYESCTPQYYLDIATKTCKECDWSCNACTGPLRTDCLQCMDGYVLQDGVCVEQCSPQHYRDSGSCKRCDSHCVECQGPHECTRCEEPFLLFQAQCVQECGKGYFADHAKHRCIACPQGCLRCSHKDRCHLCDHSFFLKSGLCMPTCVPGFSGHSSNENCTDKMYTPSLHVNGSLTLGIGSMKPLDFSLLNIQHQDGRVEDLLFHVVSTPTNGQLLLSRNGKEVQLEKAGHFSWKDVNEKKVRFVHSKEKLRKGYFSLKISDQQFFSEPQLINIQAFSTQAPYVLRNEVLHVSKGERATITTQLLDIRDDDNPQDVVVNVLDPPLHGQLLQMPPAPAASIYQFHLDELSRGLLLYAHDGSDSTSDIIVFQANDGHSFQNILFHVKNIPKNDRALRLVTNSMVWVPEGGMLKITNRILKAQAPGVRADDIIYKITHSRPQFGEVVLLMNLPADSPAGPAEEGHHLPDGRMATPISTFTQQDIDDGVVWYRHLGAPTQSDSFRFQVSSATSAQEHLESHMFNIAILPQAPEAPKLSLGTSLHMTAREDGLSVIQPQSLSFVKAESPSGKIIYNITVPLHPNQGIIEHRDRPHSPIQYFTQEDINQGQIMYRPPVAPPHLQEIMAFSFAGLPESVKFYFTVSDGQHTSPEMALTIHLLHSDLQPPAFQVKAPLLEVSPGGRTSLGLQLLVRDAQVVPEELFFQLQKSPQHGMLVKYTAKSSVTMAAGDTFTYDEVERNVLQYVHDGSSAWEDSLEISVTDGLTVTTSEVKVEVSPSENRGPRLAPGSSLSMTVASQHTAIITRSHLAYVDDSSSDPEIWIRLSSLPLYGVLFRSSGPDMDELSGDSNFTMEDINKKNIRYSAVFETDGHSVTDGFHFSVSDMDGNHVDNQVFTITVTPAENPPHIIAFADLITVDEGGRAPLSLHHFFATEDQDNLQDDAVIKLSALPKYGCIENTGTGDRFGPGANSELEASFPIQDVLENYIYYFQSVHESIEPTHDVFSFYVSDGSGRSEIHSINITIERKNDEPPRMTLRPLGVRLSSGVAISNSSLSLQDLDTPDNELIFVLMKKPDHGHLLRRSTASDPLENGTVLDQGSSFTYQDVLAGLVGYLPGDIYMAVDEFRFSLTDGLHVDTGRMEIYIELPSTNIPHLAINRGLQLSAGSVARITEQHLKATDTDSEAGQVVYIMKEDPGAGRLLMAKADNLEQISVRGPIRSFTQADVSQGQIEYSHGPGEPGGSFAFKFDVVDGEGNKLADQSFSIGVLEDKSPPVVITNRGLVLDENSVEKITTAQLSATDQDSKPTELIYRITTQPQLGHLEHVASPGIQISSFTQADLASRNVQYVRSSGTGKQSDAFSFVLSDGLHEVTQTFPITIHPVDDARPLVQNRGMRVQEGVRKTITEFELKAVDVDTEAESITFTIVQPPRHGTIERTARGQRFHQTSSFTMEDIYQNRVSYSHDGSNSLKDRFTFTVSDGTNPFFIIEEGGEEIMTAAPQQFHVDILPVDDGTPRIVTNLGLQWLEYMDGKATNLITKKELLTVDPDTEDSQLIYEVTTGPMHGYLENKLQPGRAAATFTQEHVNLGLIRYVLYEEKIQKVMDSFQFLVKDSKPNVVSDNVFHIQWSLISFKYTSYNVSEKAGSVSVTVQRTGNLNQYAIVLCRTEQGTASSSSHPGQQDYMEYAGQVQFDEGEGTKSCTVIINDDDVFENIESFTVGLSMPAYALLGEFTQAKVVINDTEDEPTLEFDKKTYRVNESAGFLFAPIKRQGDSSSTVSAVCYTVPKSAMGSSLYALESGSDFKSRGRSAESRVIFGPGVTVSTCDVMVIDDSEYEEEEEFEIALADASNNARIGRQAVAKVLISGPNDASTVSLGNTAFTISEDAGTVKIPVIRHGTDLSTFTSVWCATRPSDPASATPGVDYVPSSRKVEFGPGITEQYCTLTILDDTQYPVIEGLETFVVFLSSAQGAELTKPSQAVIAINDTFQDVPSMQFSKDLLLVKEKEGVLHIPIIRSGDLSYESSVRCYTQGHSAQVMEDFEERRNADSSRITFLKGQKTKNCTVYIHDDSMFEPEEQFRVYLGHPLGNHWSGARIGKNSVATVTISNDEDAPTIEFEEAAYQVREPAGPEAIAVLSIKVIRRGDQNRTSKIRCSTRDGSAQSGVDYYPKSRVLKFSPGVDHIFFKVEILSNEDREWHESFSLVLGPDDLVEAVLGDVTTATVTILDQEAAGSLILPAPPIVVTLADYDHVEELAKEGVKKAPSPGYPLVCVTPCDPRYPRYAVMKERCSEAGINQTSVQFSWEVAAPTDGNGARSPFETITDNTPFTSVNHKVLDSIYFSRRFHVRCVAKAVDKVGHVGTPLRSNVVTIGTDSAICHTPVVAGTARGFQAQSFIATLKYLDVKHKEHPNRIHISVQIPHQDGMLPLISTMPLHNLHFLLSESIYRHQHVCSNLVTAQDLRGLAEAGFLNDAGFHSTALGPGYDRPFQFDSSVREPKTIQLYRHLNLKSCVWTFDAYYDMTELIDVCGGSVTADFQVRDSAQSFLTVHVPLYVSYIYVTAPRGWASLEHHTEMEFSFFYDTVLWRTGIQTDSVLSARLQIIRIYIREDGRLVIEFKTHAKFRGQFVIEHHTLPDVKSFILTPDHLGGIQFDLQLLWSAQTFDSPHQLWRATSSYNRKDYSGEYTIYLIPCTVQPTQPWVDPGEKALACTAHAPERFLIPIAFQQTNRPVPVVYSLNTEFQLCNNEKVFLMDPNTSDMSLAEMDYKGAFSKGQILYGRVLWNPEQNLHSAYKLQLEKVYLCTGKDGYVPFFDPTGTIYNEGPQYGCIQPNKHLKHRFLLLDRSQPEVTDKYFHDVPFEAHFASELPDFQVVSSMPGVDGFTLKVDALYKVEAGHQWYLQVIYIIGPDSTSRPRVQRSLTVSLRRHQRDLVDPSGWLSLDDSLIYDNEGDQVKNGTNMKSLNLEMQEPVIAASLSQTGASIGSALAAIMLLLLLFLVACFVTRKCQKQKKKQPPEDTLEEYPLNTKVDVAKRNADKVEKNANRQYCTVRNVNILSDNEGYYTFKGAKVKKLNLEVRVHNNLQDGTEV
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Fras1 are the cause of blebbed (bl) phenotype, which is characterized by blister formation, syndactyly, eyelid fusion and renal agenesis. Subepidermal blisters are predominantly formed in the head region around the eyes and at the distal part of the limbs. As development proceeds blisters that are initially transparent gradually become hemorrhagic and embryos die between 14.5 dpc and 16.5 dpc. {ECO:0000269|PubMed:12766769, ECO:0000269|PubMed:12766770, ECO:0000269|PubMed:32333816}.
uniprot
proteins
function
FUNCTION: Involved in extracellular matrix organization (PubMed:32333816). Required for the regulation of epidermal-basement membrane adhesion responsible for proper organogenesis during embryonic development (PubMed:12766769). Involved in brain organization and function (PubMed:32333816). {ECO:0000269|PubMed:12766769, ECO:0000269|PubMed:32333816}.
uniprot
proteins
mass_dalton
442369
uniprot
proteins
protein_family
FRAS1 family
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
12766769
uniprot
proteins
pubmed
12766770
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32333816
uniprot
proteins
sequence_length
4010
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12766769, ECO:0000269|PubMed:32333816}; Single-pass type I membrane protein {ECO:0000305}; Extracellular side {ECO:0000269|PubMed:12766769, ECO:0000269|PubMed:32333816}.
uniprot
proteins
transmembrane_region
TRANSMEM 3904..3924; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins