ASTE1
entrez
28990
canonical
uniprot
Q2TB18
canonical
ensembl
ENSG00000034533
resolver
ensp
ENSP00000264992
resolver
ensp
ENSP00000426421
resolver
ensp
ENSP00000544948
resolver
ensp
ENSP00000598698
resolver
ensp
ENSP00000745524
resolver
enst
ENST00000514044
resolver
enst
ENST00000874889
resolver
enst
ENST00000928639
resolver
genesymbol
ASTE1
resolver
hgnc
HGNC:25021
resolver
uniprot
B4DFL9
resolver
uniprot
D6RG30
resolver
uniprot
Q3MIB6
resolver
uniprot
Q8N6G4
resolver
uniprot
Q96JY1
resolver
uniprot
Q9UHX6
resolver
uniprot_entry
ASTE1_HUMAN
resolver
uniprot_entry
D6RG30_HUMAN
resolver
uniprot_sec
B4DFL9
resolver
uniprot_sec
Q3MIB6
resolver
uniprot_sec
Q8N6G4
resolver
uniprot_sec
Q96JY1
resolver
uniprot_sec
Q9UHX6
resolver
amino_acid_sequence
MGIRGLMSFVEDHSNEFFTDLKLRDTKIVIDGYALFHRLCFSSNLDLRYGGDYDSFADVVQKFFESLFACNICPYVVLDGGCDISDKKLTTLKDRAREKIQMAHSLSVGGSGYVCPLLIREVFIQVLIKLRVCFVQCFSEADRDIMTLANHWNCPVLSSDSDFCIFDLKTGFCPLNSFQWRNMNTIKGTQNYIPAKCFSLDAFCHHFSNMNKALLPLFAVLCGNDHVNLPIMETFLSKARLPLGATSSKGRRHHRILGLLNWLSHFANPTEALDNVLKYLPKKDRENVKELLCCSMEEYQQSQVKLQDFFQCGTYVCPDALNLGLPEWVLVALAKGQLSPFISDALVLRRTILPTQVENMQQPNAHRISQPIRQIIYGLLLNASPHLDKTSWNALPPQPLAFSEVERINKNIRTSIIDAVELAKDHSDLSRLTELSLRRRQMLLLETLKVKQTILEPIPTSLKLPIAVSCYWLQHTETKAKLHHLQSLLLTMLVGPLIAIINSPGKEELQEDGAKMLYAEFQRVKAQTRLGTRLDLDTAHIFCQWQSCLQMGMYLNQLLSTPLPEPDLTRLYSGSLVHGLCQQLLASTSVESLLSICPEAKQLYEYLFNATRSYAPAEIFLPKGRSNSKKKRQKKQNTSCSKNRGRTTAHTKCWYEGNNRFGLLMVENLEEHSEASNIE
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: Structure-specific DNA endonuclease that specifically cleaves single-stranded DNA and 3' overhang DNA. Contributes to the control of DNA double-strand break repair choice by antagonizing BRCA1-dependent homologous recombination (HR) and promoting non-homologous end-joining (NHEJ). Recruited to the single-stranded DNA ends by SHLD2 and cleaves the 3' exposed DNA ends, therefore inhibiting DNA end resection (necessary for HR) and promoting DNA end protection (necessary for NHEJ). {ECO:0000269|PubMed:34354233}.
uniprot
proteins
mass_dalton
77093
uniprot
proteins
mutagenesis
MUTAGEN 252; /note="R->A: Loss of single-strand DNA endonuclease activity."; /evidence="ECO:0000269|PubMed:34354233
uniprot
proteins
protein_family
Asteroid family
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
34354233
uniprot
proteins
sequence_length
679
uniprot
proteins