Msx2
entrez
17702
canonical
uniprot
Q03358
canonical
ensembl
ENSMUSG00000021469
resolver
ensp
ENSMUSP00000021922
resolver
enst
ENSMUST00000021922
resolver
genesymbol
Msx2
resolver
genesymbol_syn
Hox-8.1
resolver
genesymbol_syn
Msx-2
resolver
uniprot
Q3UZH5
resolver
uniprot
Q63856
resolver
uniprot_entry
MSX2_MOUSE
resolver
uniprot_entry
Q3UZH5_MOUSE
resolver
uniprot_sec
Q63856
resolver
amino_acid_sequence
MASPTKGGDLFSSDEEGPAVLAGPGPGPGGAEGSAEERRVKVSSLPFSVEALMSDKKPPKESPAVPPDCASAGAVLRPLLLPGHGVRDAHSPGPLVKPFETASVKSENSEDGAPWIQEPGRYSPPPRHMSPTTCTLRKHKTNRKPRTPFTTSQLLALERKFRQKQYLSIAERAEFSSSLNLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPSGFSLPFPINSPLQAASIYGASYPFHRPVLPIPPVGLYATPVGYGMYHLS
uniprot
proteins
function
FUNCTION: Acts as a transcriptional regulator in bone development. Represses the ALPL promoter activity and antagonizes the stimulatory effect of DLX5 on ALPL expression during osteoblast differentiation. Probable morphogenetic role. May play a role in limb-pattern formation. In osteoblasts, suppresses transcription driven by the osteocalcin FGF response element (OCFRE). Binds to the homeodomain-response element of the ALPL promoter. {ECO:0000269|PubMed:15383550, ECO:0000269|PubMed:1677742}.
uniprot
proteins
mass_dalton
28915
uniprot
proteins
protein_family
Msh homeobox family
uniprot
proteins
pubmed
10451362
uniprot
proteins
pubmed
15383550
uniprot
proteins
pubmed
1673109
uniprot
proteins
pubmed
1677742
uniprot
proteins
pubmed
1682128
uniprot
proteins
pubmed
8098007
uniprot
proteins
sequence_length
267
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins