Cited1
entrez
12705
canonical
uniprot
P97769
canonical
ensembl
ENSMUSG00000051159
resolver
ensp
ENSMUSP00000051789
resolver
ensp
ENSMUSP00000098890
resolver
ensp
ENSMUSP00000338691
resolver
enst
ENSMUST00000050551
resolver
enst
ENSMUST00000101336
resolver
genesymbol
Cited1
resolver
genesymbol_syn
Msg1
resolver
uniprot
Q3UGA1
resolver
uniprot_entry
CITE1_MOUSE
resolver
uniprot_entry
Q3UGA1_MOUSE
resolver
amino_acid_sequence
MPTMSRPALDVKGGTTSGKEDANQEMNSLAYSNLGVKDRKAVTVLHYPGVTANGAKANGVPTSSSGSTSPIGSPTATPSSKPPSFNLHPTPHLMASMQLQKLNSQYQGAAATAAAALTGAGLPGEEEPMQNWVTAPLVVGGSPGSVSPPAGAQSPALIDSDPVDEEVLMSLVVELGLDRANELPELWLGQNEFDFTADFPSGC
uniprot
proteins
function
FUNCTION: Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner. {ECO:0000269|PubMed:10722728, ECO:0000269|PubMed:14673158, ECO:0000269|PubMed:18187554}.
uniprot
proteins
mass_dalton
20800
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation changes in a cell cycle-dependent manner and reduces its transcriptional cofactor activity (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
CITED family
uniprot
proteins
pubmed
10722728
uniprot
proteins
pubmed
11581164
uniprot
proteins
pubmed
14673158
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17938205
uniprot
proteins
pubmed
18187554
uniprot
proteins
pubmed
8901575
uniprot
proteins
sequence_length
203
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11581164, ECO:0000269|PubMed:14673158, ECO:0000269|PubMed:17938205}. Cytoplasm {ECO:0000250}. Note=Shuttles between the nucleus and the cytoplasm by a nuclear export signal (NES) and in a CRM1-dependent manner. {ECO:0000250}.
uniprot
proteins