PLA2G7
entrez
7941
canonical
uniprot
Q13093
canonical
ensembl
ENSG00000146070
resolver
ensp
ENSP00000274793
resolver
ensp
ENSP00000445666
resolver
ensp
ENSP00000548380
resolver
ensp
ENSP00000548381
resolver
ensp
ENSP00000725248
resolver
enst
ENST00000274793
resolver
enst
ENST00000537365
resolver
enst
ENST00000878321
resolver
enst
ENST00000878322
resolver
genesymbol
PLA2G7
resolver
genesymbol_syn
PAFAH
resolver
hgnc
HGNC:9040
resolver
uniprot
A5HTT5
resolver
uniprot
Q15692
resolver
uniprot
Q5VTT1
resolver
uniprot
Q8IVA2
resolver
uniprot_entry
PAFA_HUMAN
resolver
uniprot_sec
A5HTT5
resolver
uniprot_sec
Q15692
resolver
uniprot_sec
Q5VTT1
resolver
uniprot_sec
Q8IVA2
resolver
amino_acid_sequence
MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGNGPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNILRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHRDRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDIDHGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMFPLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFATGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGTNINTTNQHIMLQNSSGIEKYN
uniprot
proteins
disease_involvement
DISEASE: Platelet-activating factor acetylhydrolase deficiency (PAFAD) [MIM:614278]: An enzymatic deficiency that results in exacerbated bodily response to inflammatory agents. It can be associated with several disease states including inflammatory gastrointestinal disorders, asthma and atopy. Asthmatic individuals with PAFAD may manifest aggravated respiratory symptoms. {ECO:0000269|PubMed:8675689, ECO:0000269|PubMed:9245731, ECO:0000269|PubMed:9412624, ECO:0000269|PubMed:9472966, ECO:0000269|PubMed:9759612}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.1.1.47
uniprot
proteins
function
FUNCTION: Lipoprotein-associated calcium-independent phospholipase A2 involved in phospholipid catabolism during inflammatory and oxidative stress response (PubMed:10066756, PubMed:16371369, PubMed:17090529, PubMed:2040620, PubMed:7700381, PubMed:8624782). At the lipid-aqueous interface, hydrolyzes the ester bond of fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity) (PubMed:10504265, PubMed:2040620). Specifically targets phospholipids with a short-chain fatty acyl group at sn-2 position (PubMed:2040620). Can hydrolyze phospholipids with long fatty acyl chains, only if they carry oxidized functional groups (PubMed:2040620, PubMed:8624782). Hydrolyzes and inactivates platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), a potent pro-inflammatory signaling lipid that acts through PTAFR on various innate immune cells (PubMed:10066756, PubMed:10504265, PubMed:11590221, PubMed:16371369, PubMed:18434304, PubMed:7592717, PubMed:7700381, PubMed:8624782, PubMed:8675689). Hydrolyzes oxidatively truncated phospholipids carrying an aldehyde group at omega position, preventing their accumulation in low-density lipoprotein (LDL) particles and uncontrolled pro-inflammatory effects (PubMed:2040620, PubMed:7700381). As part of high-density lipoprotein (HDL) particles, can hydrolyze phospholipids having long-chain fatty acyl hydroperoxides at sn-2 position and protect against potential accumulation of these oxylipins in the vascular wall (PubMed:17090529). Catalyzes the release from membrane phospholipids of F2-isoprostanes, lipid biomarkers of cellular oxidative damage (PubMed:16371369). {ECO:0000269|PubMed:10066756, ECO:0000269|PubMed:10504265, ECO:0000269|PubMed:11590221, ECO:0000269|PubMed:16371369, ECO:0000269|PubMed:17090529, ECO:0000269|PubMed:18434304, ECO:0000269|PubMed:2040620, ECO:0000269|PubMed:7592717, ECO:0000269|PubMed:7700381, ECO:0000269|PubMed:8624782, ECO:0000269|PubMed:8675689}.
uniprot
proteins
mass_dalton
50077
uniprot
proteins
mutagenesis
MUTAGEN 108; /note="S->A: Activity is higher than wild-type."; /evidence="ECO:0000269|PubMed:7592717"; MUTAGEN 114; /note="H->A,Q,E: Impairs the association with LDL particles."; /evidence="ECO:0000269|PubMed:10066756"; MUTAGEN 115; /note="W->A: Impairs the association with LDL particles."; /evidence="ECO:0000269|PubMed:10066756"; MUTAGEN 116; /note="L->A: Reduces the association with LDL particles."; /evidence="ECO:0000269|PubMed:10066756"; MUTAGEN 117; /note="M->A: Reduces the association with LDL particles."; /evidence="ECO:0000269|PubMed:10066756"; MUTAGEN 205; /note="Y->A: Impairs the association with LDL particles."; /evidence="ECO:0000269|PubMed:10066756"; MUTAGEN 273; /note="S->A: Loss of activity."; /evidence="ECO:0000269|PubMed:7592717"; MUTAGEN 286; /note="D->A: Almost no activity."; /evidence="ECO:0000269|PubMed:7592717"; MUTAGEN 286; /note="D->N: Diminishes activity."; /evidence="ECO:0000269|PubMed:7592717"; MUTAGEN 296; /note="D->A: Loss of activity."; /evidence="ECO:0000269|PubMed:7592717"; MUTAGEN 296; /note="D->N: Loss of activity."; /evidence="ECO:0000269|PubMed:7592717"; MUTAGEN 304; /note="D->A: No change in activity."; /evidence="ECO:0000269|PubMed:7592717"; MUTAGEN 338; /note="D->A: Activity is higher than wild-type."; /evidence="ECO:0000269|PubMed:7592717"; MUTAGEN 351; /note="H->A: Loss of activity."; /evidence="ECO:0000269|PubMed:7592717"; MUTAGEN 367; /note="H->N: Reduces the association with HDL particles."; /evidence="ECO:0000269|PubMed:18434304"; MUTAGEN 368; /note="M->K: Impairs the association with HDL particles."; /evidence="ECO:0000269|PubMed:18434304"; MUTAGEN 369; /note="L->A: Impairs the association with HDL particles."; /evidence="ECO:0000269|PubMed:18434304"; MUTAGEN 370; /note="K->T: Reduces the association with HDL particles."; /evidence="ECO:0000269|PubMed:18434304
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. Macrophage-derived PLA2G7 carries sialylated complex-type N-glycans that hinder its binding to HDL particles. {ECO:0000269|PubMed:11590221}.
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
protein_family
Lipase family
uniprot
proteins
pubmed
10066756
uniprot
proteins
pubmed
10504265
uniprot
proteins
pubmed
10733466
uniprot
proteins
pubmed
11590221
uniprot
proteins
pubmed
12821559
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16371369
uniprot
proteins
pubmed
17090529
uniprot
proteins
pubmed
18434304
uniprot
proteins
pubmed
18784071
uniprot
proteins
pubmed
19394314
uniprot
proteins
pubmed
2040620
uniprot
proteins
pubmed
7592717
uniprot
proteins
pubmed
7700381
uniprot
proteins
pubmed
8624782
uniprot
proteins
pubmed
8675689
uniprot
proteins
pubmed
9245731
uniprot
proteins
pubmed
9412624
uniprot
proteins
pubmed
9472966
uniprot
proteins
pubmed
9759612
uniprot
proteins
sequence_length
441
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000269|PubMed:10066756, ECO:0000269|PubMed:11590221, ECO:0000269|PubMed:12821559, ECO:0000269|PubMed:18434304}. Note=Associates with both LDL and HDL particles in plasma (PubMed:10066756, PubMed:11590221, PubMed:12821559, PubMed:18434304). Mainly associates with pro-inflammatory electronegative LDL particles (PubMed:12821559). {ECO:0000269|PubMed:10066756, ECO:0000269|PubMed:11590221, ECO:0000269|PubMed:12821559, ECO:0000269|PubMed:18434304}.
uniprot
proteins