SKAP1
entrez
8631
canonical
uniprot
Q86WV1
canonical
ensembl
ENSG00000141293
resolver
ensp
ENSP00000338171
resolver
ensp
ENSP00000522341
resolver
ensp
ENSP00000691596
resolver
genesymbol
HEL-S-81p
resolver
genesymbol
SKAP1
resolver
genesymbol_syn
SCAP1
resolver
genesymbol_syn
SKAP55
resolver
hgnc
HGNC:15605
resolver
uniprot
D3DTV1
resolver
uniprot
O15268
resolver
uniprot
V9HW03
resolver
uniprot_entry
SKAP1_HUMAN
resolver
uniprot_entry
V9HW03_HUMAN
resolver
uniprot_sec
D3DTV1
resolver
uniprot_sec
O15268
resolver
amino_acid_sequence
MQAAALPEEIRWLLEDAEEFLAEGLRNENLSAVARDHRDHILRGFQQIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDYQDEGMEDIVKGAQELDNVIKQGYLEKKSKDHSFFGSEWQKRWCVVSRGLFYYYANEKSKQPKGTFLIKGYGVRMAPHLRRDSKKESCFELTSQDRRSYEFTATSPAEARDWVDQISFLLKDLSSLTIPYEEDEEEEEKEETYDDIDGFDSPSCGSQCRPTILPGSVGIKEPTEEKEEEDIYEVLPDEEHDLEEDESGTRRKGVDYASYYQGLWDCHGDQPDELSFQRGDLIRILSKEYNMYGWWVGELNSLVGIVPKEYLTTAFEVEER
uniprot
proteins
function
FUNCTION: Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. {ECO:0000269|PubMed:10856234, ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:12652296, ECO:0000269|PubMed:15939789, ECO:0000269|PubMed:16980616}.
uniprot
proteins
mass_dalton
41432
uniprot
proteins
mutagenesis
MUTAGEN 219; /note="Y->F: Impairs interaction with PTPRC. No effect on interaction with FYN or GRB2."; /evidence="ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:12171928"; MUTAGEN 232; /note="Y->F: Abolishes interaction with PTPRC, translocation to cell membrane upon T-cell stimulation and activation of the MAP kinase pathway. No effect on interaction with FYN or GRB2."; /evidence="ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:12171928"; MUTAGEN 271; /note="Y->F: No effect on interaction with PTPRC and translocation to cell membrane upon T-cell stimulation. Abolishes interaction with FYN and GRB2 and activation of the MAP kinase pathway."; /evidence="ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:12171928"; MUTAGEN 295; /note="Y->F: Abolishes FYB1-dependent activation of ITGAL clustering."; /evidence="ECO:0000269|PubMed:10856234"; MUTAGEN 298; /note="Y->F: Impairs interaction with FYB1."; /evidence="ECO:0000269|PubMed:10856234"; MUTAGEN 333; /note="W->R: Abolishes homodimerization, interaction with FYB1 and activation of the MAP kinase pathway."; /evidence="ECO:0000269|PubMed:12171928, ECO:0000269|PubMed:15849195, ECO:0000269|PubMed:9748251
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosines. Phosphorylation by FYN on Tyr-271 is required for GRB2 interaction. Phosphorylation by FYN on Tyr-295 abolishes interaction with FYB1. Tyr-232 is dephosphorylated by PTPRC (Probable). {ECO:0000305|PubMed:11909961, ECO:0000305|PubMed:12171928, ECO:0000305|PubMed:16461356, ECO:0000305|PubMed:9195899}.
uniprot
proteins
protein_family
SKAP family
uniprot
proteins
pubmed
10856234
uniprot
proteins
pubmed
11909961
uniprot
proteins
pubmed
12171928
uniprot
proteins
pubmed
12652296
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15849195
uniprot
proteins
pubmed
15939789
uniprot
proteins
pubmed
16461356
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16980616
uniprot
proteins
pubmed
17658605
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
27335501
uniprot
proteins
pubmed
9195899
uniprot
proteins
pubmed
9671755
uniprot
proteins
pubmed
9748251
uniprot
proteins
sequence_length
359
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:9671755}. Nucleus {ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:9671755}. Cell membrane {ECO:0000269|PubMed:11909961, ECO:0000269|PubMed:9671755}. Note=Upon T-cell stimulation, translocates to lipid rafts at the cell membrane. {ECO:0000269|PubMed:9671755}.
uniprot
proteins