Tnfrsf11b
entrez
18383
canonical
uniprot
O08712
canonical
ensembl
ENSMUSG00000063727
resolver
ensp
ENSMUSP00000078705
resolver
enst
ENSMUST00000079772
resolver
genesymbol
Tnfrsf11b
resolver
genesymbol_syn
Ocif
resolver
genesymbol_syn
Opg
resolver
uniprot
O70202
resolver
uniprot
Q3UK97
resolver
uniprot_entry
Q3UK97_MOUSE
resolver
uniprot_entry
TR11B_MOUSE
resolver
uniprot_sec
O70202
resolver
amino_acid_sequence
MNKWLCCALLVLLDIIEWTTQETLPPKYLHYDPETGHQLLCDKCAPGTYLKQHCTVRRKTLCVPCPDHSYTDSWHTSDECVYCSPVCKELQSVKQECNRTHNRVCECEEGRYLEIEFCLKHRSCPPGSGVVQAGTPERNTVCKKCPDGFFSGETSSKAPCIKHTNCSTFGLLLIQKGNATHDNVCSGNREATQKCGIDVTLCEEAFFRFAVPTKIIPNWLSVLVDSLPGTKVNAESVERIKRRHSSQEQTFQLLKLWKHQNRDQEMVKKIIQDIDLCESSVQRHLGHSNLTTEQLLALMESLPGKKISPEEIERTRKTCKSSEQLLKLLSLWRIKNGDQDTLKGLMYALKHLKTSHFPKTVTHSLRKTMRFLHSFTMYRLYQKLFLEMIGNQVQSVKISCL
uniprot
proteins
function
FUNCTION: Acts as a decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis in vitro. Bone homeostasis seems to depend on the local ratio between TNFSF11 and TNFRSF11B. May also play a role in preventing arterial calcification. May act as decoy receptor for TNFSF10/TRAIL and protect against apoptosis. TNFSF10/TRAIL binding blocks the inhibition of osteoclastogenesis. {ECO:0000269|PubMed:10952716}.
uniprot
proteins
mass_dalton
45923
uniprot
proteins
pubmed
10952716
uniprot
proteins
pubmed
23039992
uniprot
proteins
pubmed
9108485
uniprot
proteins
pubmed
9714833
uniprot
proteins
sequence_length
401
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins