Cenpu
entrez
306464
canonical
uniprot
Q4V8G7
canonical
ensembl
ENSRNOG00000022261
resolver
ensembl
ENSRNOG00055011439
resolver
ensp
ENSRNOP00000046417
resolver
ensp
ENSRNOP00055015652
resolver
enst
ENSRNOT00000041596
resolver
enst
ENSRNOT00055019419
resolver
genesymbol
Cenpu
resolver
genesymbol_syn
Mlf1ip
resolver
uniprot_entry
CENPU_RAT
resolver
amino_acid_sequence
MAARRSLRYSGDPGAKRSRNTLGSTNSRKQKAGQKPKRKDVFDFPNTSDVSSMLRELEEEEPYETFDPPLHSTAIYTDDELYKHCVSSTSPATHRGKESRNLNPSENEASGNDSIKLSAKKPRRKLEPISDESDSSEDNVRRSVSIERPRARKPPAAPAAASSSSSPSERPAEQVTPRKTSFPQPSAVEETPAAQSQLKTQKKVRPSPGRRKRPRRGSTHSDASESMHILCLEGKRQSDVMELDVVLSAFERTFLDYKQRVESESCNQAISKFYFKIKGELIRMLKEVQMLKALKRKNTKIISNMEKKRQRLIDVQDELIRLEPQLKQLQTKYDDLKKRKSALKNSKHFLSNLKQLYQDYSNVREEEPKEKEKYDSSSLPALLFKARSILGAEKHLKTINYHLGKLLKQD
uniprot
proteins
function
FUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
46801
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PLK1 at Thr-73, creating a self-tethering site that specifically interacts with the polo-box domain of PLK1. {ECO:0000250}.
uniprot
proteins
protein_family
CENP-U/AME1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15893739
uniprot
proteins
sequence_length
410
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15893739}. Nucleus {ECO:0000269|PubMed:15893739}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Localizes in the kinetochore domain of centromeres. Colocalizes with PLK1 at the interzone between the inner and the outer kinetochore plates (By similarity). {ECO:0000250}.
uniprot
proteins