Fzd4
entrez
14366
canonical
uniprot
Q61088
canonical
ensembl
ENSMUSG00000049791
resolver
ensp
ENSMUSP00000049852
resolver
enst
ENSMUST00000058755
resolver
genesymbol
Fzd4
resolver
uniprot
Q3V1B2
resolver
uniprot
Q8BKU9
resolver
uniprot
Q8BLL2
resolver
uniprot_entry
FZD4_MOUSE
resolver
uniprot_entry
Q3V1B2_MOUSE
resolver
uniprot_entry
Q8BKU9_MOUSE
resolver
uniprot_entry
Q8BLL2_MOUSE
resolver
amino_acid_sequence
MAWPGTGPSSRGAPGGVGLRLGLLLQFLLLLRPTLGFGDEEERRCDPIRIAMCQNLGYNVTKMPNLVGHELQTDAELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLREFGFAWPDTLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEECHSVGSNSDQYIWVKRSLNCVLKCGYDAGLYSRSAKEFTDIWMAVWASLCFISTTFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCDFEEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIEMHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVIGTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEISNWALFRYSADDSNMAVEMLKIFMSLLVGITSGMWIWSAKTLHTWQKCSNRLVNSGKVKREKRGNGWVKPGKGNETVV
uniprot
proteins
function
FUNCTION: Receptor for Wnt proteins (PubMed:10097073). Most frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes (PubMed:19837033). Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP) (PubMed:19837033). In retina, it can be activated by Wnt protein-binding and also by Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs (PubMed:19837033). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Activation by Wnt5A stimulates PKC activity via a G protein-dependent mechanism. {ECO:0000250|UniProtKB:Q9ULV1, ECO:0000269|PubMed:10097073, ECO:0000269|PubMed:19837033}.
uniprot
proteins
mass_dalton
60143
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. {ECO:0000250}.
uniprot
proteins
protein_family
G protein-coupled receptor Fz/Smo family
uniprot
proteins
pubmed
10097073
uniprot
proteins
pubmed
10395542
uniprot
proteins
pubmed
15035989
uniprot
proteins
pubmed
15195140
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19837033
uniprot
proteins
pubmed
21856951
uniprot
proteins
pubmed
8626800
uniprot
proteins
sequence_length
537
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10097073}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 213..243; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q9ULV1"; TRANSMEM 250..275; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q9ULV1"; TRANSMEM 300..333; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q9ULV1"; TRANSMEM 337..365; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q9ULV1"; TRANSMEM 384..410; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q9ULV1"; TRANSMEM 432..460; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q9ULV1"; TRANSMEM 474..495; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q9ULV1
uniprot
proteins