SAV1
entrez
60485
canonical
uniprot
Q9H4B6
canonical
ensembl
ENSG00000151748
resolver
ensp
ENSP00000324729
resolver
ensp
ENSP00000451492
resolver
ensp
ENSP00000660208
resolver
enst
ENST00000324679
resolver
genesymbol
SAV1
resolver
genesymbol_syn
WW45
resolver
hgnc
HGNC:17795
resolver
uniprot
A8K4B8
resolver
uniprot
B3KTQ1
resolver
uniprot
D3DSB6
resolver
uniprot
Q6IA58
resolver
uniprot
Q9H949
resolver
uniprot
Q9HAK9
resolver
uniprot_entry
B3KTQ1_HUMAN
resolver
uniprot_entry
SAV1_HUMAN
resolver
uniprot_sec
A8K4B8
resolver
uniprot_sec
D3DSB6
resolver
uniprot_sec
Q6IA58
resolver
uniprot_sec
Q9H949
resolver
uniprot_sec
Q9HAK9
resolver
amino_acid_sequence
MLSRKKTKNEVSKPAEVQGKYVKKETSPLLRNLMPSFIRHGPTIPRRTDICLPDSSPNAFSTSGDVVSRNQSFLRTPIQRTPHEIMRRESNRLSAPSYLARSLADVPREYGSSQSFVTEVSFAVENGDSGSRYYYSDNFFDGQRKRPLGDRAHEDYRYYEYNHDLFQRMPQNQGRHASGIGRVAATSLGNLTNHGSEDLPLPPGWSVDWTMRGRKYYIDHNTNTTHWSHPLEREGLPPGWERVESSEFGTYYVDHTNKKAQYRHPCAPSVPRYDQPPPVTYQPQQTERNQSLLVPANPYHTAEIPDWLQVYARAPVKYDHILKWELFQLADLDTYQGMLKLLFMKELEQIVKMYEAYRQALLTELENRKQRQQWYAQQHGKNF
uniprot
proteins
function
FUNCTION: Regulator of STK3/MST2 and STK4/MST1 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:29063833). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for STK3/MST2 and STK4/MST1 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues. Plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosomes, and its ability to phosphorylate CROCC and CEP250. In conjunction with STK3/MST2, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. {ECO:0000269|PubMed:16930133, ECO:0000269|PubMed:19212654, ECO:0000269|PubMed:21076410, ECO:0000269|PubMed:21104395, ECO:0000269|PubMed:29063833}.
uniprot
proteins
mass_dalton
44634
uniprot
proteins
mutagenesis
MUTAGEN 346; /note="E->A: Loss of interaction with STK3."; /evidence="ECO:0000269|PubMed:29063833"; MUTAGEN 350; /note="I->A: Loss of interaction with STK3."; /evidence="ECO:0000269|PubMed:29063833"; MUTAGEN 357; /note="Y->A: Loss of interaction with STK3."; /evidence="ECO:0000269|PubMed:29063833"; MUTAGEN 358; /note="R->A: Loss of interaction with STK3."; /evidence="ECO:0000269|PubMed:29063833"; MUTAGEN 361; /note="L->A: Loss of interaction with STK3."; /evidence="ECO:0000269|PubMed:29063833"; MUTAGEN 365; /note="L->A: Loss of interaction with STK3."; /evidence="ECO:0000269|PubMed:29063833"; MUTAGEN 368; /note="R->A: Loss of interaction with STK3."; /evidence="ECO:0000269|PubMed:29063833
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by STK3/MST2 and STK4/MST1. Phosphorylation is not required for SAV1 stability and may increase the number of protein binding sites on the scaffold molecule. {ECO:0000269|PubMed:16930133}.
uniprot
proteins
pubmed
11027580
uniprot
proteins
pubmed
12202036
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15688006
uniprot
proteins
pubmed
16930133
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19212654
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
20303269
uniprot
proteins
pubmed
21076410
uniprot
proteins
pubmed
21104395
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28087714
uniprot
proteins
pubmed
29063833
uniprot
proteins
sequence_length
383
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:19212654}. Cytoplasm {ECO:0000269|PubMed:19212654, ECO:0000269|PubMed:29063833}.
uniprot
proteins