Cnnm2
entrez
94219
canonical
uniprot
Q3TWN3
canonical
ensembl
ENSMUSG00000064105
resolver
ensp
ENSMUSP00000076850
resolver
ensp
ENSMUSP00000096972
resolver
genesymbol
Cnnm2
resolver
genesymbol_syn
Acdp2
resolver
uniprot
A0PJF1
resolver
uniprot
E9PUH1
resolver
uniprot
Q7TT07
resolver
uniprot
Q8C8V4
resolver
uniprot
Q9JIM8
resolver
uniprot_entry
CNNM2_MOUSE
resolver
uniprot_sec
A0PJF1
resolver
uniprot_sec
E9PUH1
resolver
uniprot_sec
Q7TT07
resolver
uniprot_sec
Q8C8V4
resolver
uniprot_sec
Q9JIM8
resolver
amino_acid_sequence
MIGCGACEPEVKMAGGQAAAALPTWKMAARRSLSARGRGVLQAAAGRLLPLLLLSCCWGAGGCTAAGENEETVIIGLRLEDTNDVSFMEGGALRVSERTRVKLRVYGQNINNETWSRIAFTEHERRRHTPSERGLGGPAPPEPDSGPQRCGIRTSDIIILPHIILNRRTSGIIEIEIKPLRKMEKSKSYYLCTSLSTPALGAGGSGSASGTVGGKGGAGVAGLPPPPWAETTWIYHDGEDTKMIVGEEKKFLLPFWLQVIFISLLLCLSGMFSGLNLGLMALDPMELRIVQNCGTEKEKNYAKRIEPVRRQGNYLLCSLLLGNVLVNTTLTILLDDIAGSGLVAVVVSTIGIVIFGEIVPQAICSRHGLAVGANTIFLTKFFMMMTFPASYPVSKLLDCVLGQEIGTVYNREKLLEMLRVTDPYNDLVKEELNIIQGALELRTKTVEDVMTPLRDCFMITGEAILDFNTMSEIMESGYTRIPVFEGERSNIVDLLFVKDLAFVDPDDCTPLKTITKFYNHPLHFVFNDTKLDAMLEEFKKGKSHLAIVQRVNNEGEGDPFYEVLGIVTLEDVIEEIIKSEILDETDLYTDNRTKKKVAHRERKQDFSAFKQTDSEMKVKISPQLLLAMHRFLATEVEAFSPSQMSEKILLRLLKHPNVIQELKYDEKNKKAPECYLYQRNKPVDYFVLILQGKVEVEAGKEGMKFEASAFSYYGVMALTASPVPLSLSRTFVVSRTEVLAAGSPGENKSPPRPCGLNHSDSLSRSDRIDAMTPTLGSSNNQLSSSFLQVYIPDYSVRALSDLQFVKISRQQYQNALMASRMDKTPQSSDSENTKIELTLTELHDGLPDETANLLNEQNCVSHNKANHSLHSEGAI
uniprot
proteins
function
FUNCTION: Divalent metal cation transporter. Mediates transport of divalent metal cations in an order of Mg(2+) > Co(2+) > Mn(2+) > Sr(2+) > Ba(2+) > Cu(2+) > Fe(2+). {ECO:0000269|PubMed:15899945}.
uniprot
proteins
mass_dalton
96704
uniprot
proteins
mutagenesis
MUTAGEN 62..65; /note="GCTA->LLLV: Impairs N-terminal cleavage."; /evidence="ECO:0000269|PubMed:22399287"; MUTAGEN 62..64; /note="GCT->LCL: No effect on N-terminal cleavage."; MUTAGEN 63..65; /note="CTA->LTV: No effect on N-terminal cleavage."; MUTAGEN 112; /note="N->A: Loss of N-glycosylation; 90% decrease of plasma membrane expression."; /evidence="ECO:0000269|PubMed:22399287"; MUTAGEN 327; /note="N->A: No effect on N-glycosylation."; /evidence="ECO:0000269|PubMed:22399287"; MUTAGEN 527; /note="N->A: No effect on N-glycosylation."; /evidence="ECO:0000269|PubMed:22399287"; MUTAGEN 591; /note="N->A: No effect on N-glycosylation."; /evidence="ECO:0000269|PubMed:22399287
uniprot
proteins
post_translational_modification
PTM: The N-terminus is cleaved within the endoplasmic reticulum. The signal peptidase complex seems to be involved in the processing, but the exact cleavage site has not been identified (PubMed:22399287). {ECO:0000269|PubMed:22399287}.
uniprot
proteins
protein_family
ACDP family
uniprot
proteins
pubmed
14723793
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15899945
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22399287
uniprot
proteins
sequence_length
875
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22399287}; Multi-pass membrane protein {ECO:0000269|PubMed:22399287}.
uniprot
proteins
transmembrane_region
TRANSMEM 251..271; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 339..359; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 369..389; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins