TATDN2
entrez
9797
canonical
uniprot
Q93075
canonical
ensembl
ENSG00000157014
resolver
ensp
ENSP00000287652
resolver
ensp
ENSP00000408736
resolver
enst
ENST00000287652
resolver
enst
ENST00000448281
resolver
genesymbol
TATDN2
resolver
genesymbol_syn
KIAA0218
resolver
hgnc
HGNC:28988
resolver
uniprot
Q3MIL9
resolver
uniprot
Q5BKU0
resolver
uniprot_entry
TATD2_HUMAN
resolver
uniprot_sec
Q3MIL9
resolver
uniprot_sec
Q5BKU0
resolver
amino_acid_sequence
MASERGKVKHNWSSTSEGCPRKRSCLREPCDVAPSSRPAQRSASRSGGPSSPKRLKAQKEDDVACSRRLSWGSSRRRNNSSSSFSPHFLGPGVGGAASKGCLIRNTRGFLSSGGSPLRPANASLEEMASLEEEACSLKVDSKDSSHNSTNSEFAAEAEGQNDTIEEPNKVQKRKRDRLRDQGSTMIYLKAIQGILGKSMPKRKGEAATRAKPSAAEHPSHGEGPARSEGPAKTAEGAARSVTVTAAQKEKDATPEVSMEEDKTVPERSSFYDRRVVIDPQEKPSEEPLGDRRTVIDKCSPPLEFLDDSDSHLEIQKHKDREVVMEHPSSGSDWSDVEEISTVRFSQEEPVSLKPSAVPEPSSFTTDYVMYPPHLYSSPWCDYASYWTSSPKPSSYPSTGSSSNDAAQVGKSSRSRMSDYSPNSTGSVQNTSRDMEASEEGWSQNSRSFRFSRSSEEREVKEKRTFQEEMPPRPCGGHASSSLPKSHLEPSLEEGFIDTHCHLDMLYSKLSFQGTFTKFRKIYSSSFPKEFQGCISDFCDPRTLTDCLWEELLKEDLVWGAFGCHPHFARYYSESQERNLLQALRHPKAVAFGEMGLDYSYKCTTPVPEQHKVFERQLQLAVSLKKPLVIHCREADEDLLEIMKKFVPPDYKIHRHCFTGSYPVIEPLLKYFPNMSVGFTAVLTYSSAWEAREALRQIPLERIIVETDAPYFLPRQVPKSLCQYAHPGLALHTVREIARVKDQPLSLTLAALRENTSRLYSL
uniprot
proteins
ec_number
3.1.13.-
uniprot
proteins
function
FUNCTION: Mg(2+)-dependent 3'RNA exonuclease and endonuclease that resolves R-loops via specific degradation of R-loop RNA structure (PubMed:37953292). Shows no activity against D-loop and minimal activity against the RNA strand of an RNA-DNA hybrid duplex oligomer. Has no 3' or 5' exonuclease activity, no uracil glycosylase activity, and no 5' flap endonuclease activity on DNA substrates (PubMed:37953292). May have a role in maintaining genomic stability through its role in R-loop resolution (PubMed:37953292). {ECO:0000269|PubMed:37953292}.
uniprot
proteins
mass_dalton
85023
uniprot
proteins
mutagenesis
MUTAGEN 593; /note="E->A: Completely abrogates R-loop RNA exonuclease activity. Decreases binding to R-loop."; /evidence="ECO:0000269|PubMed:37953292"; MUTAGEN 705; /note="E->A: Completely abrogates R-loop RNA exonuclease activity."; /evidence="ECO:0000269|PubMed:37953292"; MUTAGEN 707; /note="D->E: Decreases R-loop RNA exonuclease activity."; /evidence="ECO:0000269|PubMed:37953292
uniprot
proteins
protein_family
Metallo-dependent hydrolases superfamily
uniprot
proteins
protein_family
TatD-type hydrolase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
37953292
uniprot
proteins
pubmed
9039502
uniprot
proteins
sequence_length
761
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins