Lactb
entrez
80907
canonical
uniprot
Q9EP89
canonical
ensembl
ENSMUSG00000032370
resolver
ensp
ENSMUSP00000034929
resolver
ensp
ENSMUSP00000151155
resolver
enst
ENSMUST00000034929
resolver
enst
ENSMUST00000215172
resolver
genesymbol
Lactb
resolver
genesymbol_syn
Lact1
resolver
uniprot
A0A1L1SVF9
resolver
uniprot
B2RWI2
resolver
uniprot_entry
A0A1L1SVF9_MOUSE
resolver
uniprot_entry
B2RWI2_MOUSE
resolver
uniprot_entry
LACTB_MOUSE
resolver
amino_acid_sequence
MYRLLSSVTARAAATAGPAWDGGRRGAHRRPGLPVLGLGWAGGLGLGLGLALGAKLVVGLRGAVPIQSPADPEASGTTELSHEQALSPGSPHTPAPPAARGFSRAIESSRDLLHRIKDEVGAPGIVVGVSVDGKEVWSEGLGYADVENRVPCKPETVMRIASISKSLTMVALAKLWEAGKLDLDLPVQHYVPEFPEKEYEGEKVSVTTRLLISHLSGIRHYEKDIKKVKEEKAYKALKMVKGTPPPSDQEKELKEKGGKNNEKSDAPKAKVEQDSEARCRSAKPGKKKNDFEQGELYLKEKFENSIESLRLFKNDPLFFKPGSQFLYSTFGYTLLAAIVERASGYKYLDYMQKIFHDLDMLTTVQEENEPVIYNRARFYVYNKKKRLVNTPYVDNSYKWAGGGFLSTVGDLLKFGNAMLYGYQVGQFKNSNENLLPGYLKPETMVMMWTPVPNTEMSWDKEGKYAMAWGVVEKKQTYGSCRKQRHYASHTGGAVGASSVLLVLPEELDSEAVNNKVPPRGIIVSIICNMQSVGLNSTALKIALEFDKDRAD
uniprot
proteins
ec_number
3.4.-.-
uniprot
proteins
function
FUNCTION: Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism (By similarity). Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism (By similarity). It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein (By similarity). Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of cancer cells: probably by promoting decreased levels of PISD, thereby affecting mitochondrial lipid metabolism (PubMed:28329758). {ECO:0000250|UniProtKB:P83111, ECO:0000269|PubMed:28329758}.
uniprot
proteins
mass_dalton
60705
uniprot
proteins
protein_family
Peptidase S12 family
uniprot
proteins
pubmed
11707067
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
28329758
uniprot
proteins
sequence_length
551
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P83111}.
uniprot
proteins