Sema4d
entrez
20354
canonical
uniprot
O09126
canonical
ensembl
ENSMUSG00000021451
resolver
ensp
ENSMUSP00000021900
resolver
ensp
ENSMUSP00000105666
resolver
ensp
ENSMUSP00000105667
resolver
ensp
ENSMUSP00000105669
resolver
ensp
ENSMUSP00000316979
resolver
ensp
ENSMUSP00000316980
resolver
ensp
ENSMUSP00000316982
resolver
ensp
ENSMUSP00000317001
resolver
ensp
ENSMUSP00000317005
resolver
ensp
ENSMUSP00000340094
resolver
ensp
ENSMUSP00000340096
resolver
enst
ENSMUST00000021900
resolver
enst
ENSMUST00000110039
resolver
enst
ENSMUST00000110040
resolver
genesymbol
Sema4d
resolver
genesymbol_syn
Semacl2
resolver
genesymbol_syn
Semaj
resolver
uniprot
Q6GTM9
resolver
uniprot_entry
SEM4D_MOUSE
resolver
uniprot_sec
Q6GTM9
resolver
amino_acid_sequence
MRMCAPVRGLFLALVVVLRTAVAFAPVPRLTWEHGEVGLVQFHKPGIFNYSALLMSEDKDTLYVGAREAVFAVNALNISEKQHEVYWKVSEDKKSKCAEKGKSKQTECLNYIRVLQPLSSTSLYVCGTNAFQPTCDHLNLTSFKFLGKSEDGKGRCPFDPAHSYTSVMVGGELYSGTSYNFLGSEPIISRNSSHSPLRTEYAIPWLNEPSFVFADVIQKSPDGPEGEDDKVYFFFTEVSVEYEFVFKLMIPRVARVCKGDQGGLRTLQKKWTSFLKARLICSKPDSGLVFNILQDVFVLRAPGLKEPVFYAVFTPQLNNVGLSAVCAYTLATVEAVFSRGKYMQSATVEQSHTKWVRYNGPVPTPRPGACIDSEARAANYTSSLNLPDKTLQFVKDHPLMDDSVTPIDNRPKLIKKDVNYTQIVVDRTQALDGTFYDVMFISTDRGALHKAVILTKEVHVIEETQLFRDSEPVLTLLLSSKKGRKFVYAGSNSGVVQAPLAFCEKHGSCEDCVLARDPYCAWSPAIKACVTLHQEEASSRGWIQDMSGDTSSCLDKSKESFNQHFFKHGGTAELKCFQKSNLARVVWKFQNGELKAASPKYGFVGRKHLLIFNLSDGDSGVYQCLSEERVRNKTVSQLLAKHVLEVKMVPRTPPSPTSEDAQTEGSKITSKMPVASTQGSSPPTPALWATSPRAATLPPKSSSGTSCEPKMVINTVPQLHSEKTVYLKSSDNRLLMSLLLFIFVLFLCLFSYNCYKGYLPGQCLKFRSALLLGKKTPKSDFSDLEQSVKETLVEPGSFSQQNGDHPKPALDTGYETEQDTITSKVPTDREDSQRIDELSARDKPFDVKCELKFADSDADGD
uniprot
proteins
function
FUNCTION: Cell surface receptor for PLXNB1 and PLXNB2 that plays an important role in cell-cell signaling (By similarity). Regulates GABAergic synapse development (PubMed:23699507, PubMed:29981480). Promotes the development of inhibitory synapses in a PLXNB1-dependent manner (PubMed:23699507, PubMed:29981480). Modulates the complexity and arborization of developing neurites in hippocampal neurons by activating PLXNB1 and interaction with PLXNB1 mediates activation of RHOA (By similarity). Promotes the migration of cerebellar granule cells (PubMed:17554007). Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro) (By similarity). Induces endothelial cell migration through the activation of PTK2B/PYK2, SRC, and the phosphatidylinositol 3-kinase-AKT pathway (By similarity). {ECO:0000250|UniProtKB:Q92854, ECO:0000269|PubMed:17554007, ECO:0000269|PubMed:23699507, ECO:0000269|PubMed:29981480}.
uniprot
proteins
mass_dalton
95640
uniprot
proteins
protein_family
Semaphorin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17554007
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23699507
uniprot
proteins
pubmed
29981480
uniprot
proteins
pubmed
8969198
uniprot
proteins
sequence_length
861
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8969198}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 734..754; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins