Gpx7
entrez
67305
canonical
uniprot
Q99LJ6
canonical
ensembl
ENSMUSG00000028597
resolver
ensp
ENSMUSP00000030332
resolver
enst
ENSMUST00000030332
resolver
genesymbol
Gpx7
resolver
uniprot
Q3TNK3
resolver
uniprot_entry
GPX7_MOUSE
resolver
uniprot_entry
Q3TNK3_MOUSE
resolver
amino_acid_sequence
MVAAVATAWLLLWAAACAQSEQDFYDFKAVNIRGKLVSLEKYRGSVSLVVNVASECGFTDQNYRALQQLQRDLGPHHFNVLAFPCNQFGQQEPDTNREIENFARRTYSVSFPMFSKIAVTGTGAHPAFKYLTQTSGKEPTWNFWKYLVDPDGKVVGAWDPTVPVAEIKPRITEQVMKLILRKREDL
uniprot
proteins
ec_number
5.3.4.1
uniprot
proteins
function
FUNCTION: Acts as an endoplasmic reticulum (ER) thiol peroxidase that maintains ER redox homeostasis and supports oxidative protein folding. Rapidly reacts with hydrogen peroxide to form sulfenylated/disulfide intermediates and oxidizes protein disulfide isomerase (PDI) family members, promoting disulfide-bond formation. Functions in a redox relay with ERO1A, using ERO1A-generated H(2)O(2) to drive PDI oxidation, linking peroxide detoxification to productive disulfide formation. Protects esophageal epithelia from hydrogen peroxide-induced oxidative stress by reducing reactive oxygen species (ROS) and preventing oxidative DNA damage and double-strand breaks. {ECO:0000250|UniProtKB:Q96SL4}.
uniprot
proteins
mass_dalton
21061
uniprot
proteins
post_translational_modification
PTM: H(2)O(2) oxidizes Cys-56 to sulfenic acid, which can be resolved by Cys-85 to form an intramolecular disulfide bond. {ECO:0000250|UniProtKB:Q96SL4}.
uniprot
proteins
protein_family
Glutathione peroxidase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
186
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q96SL4}.
uniprot
proteins