Katnb1
entrez
74187
canonical
uniprot
Q8BG40
canonical
ensembl
ENSMUSG00000031787
resolver
ensp
ENSMUSP00000034239
resolver
ensp
ENSMUSP00000209110
resolver
ensp
ENSMUSP00000209116
resolver
ensp
ENSMUSP00000209124
resolver
enst
ENSMUST00000034239
resolver
genesymbol
Katnb1
resolver
uniprot
Q8CD18
resolver
uniprot
Q8R1J0
resolver
uniprot
Q9CWV2
resolver
uniprot_entry
KTNB1_MOUSE
resolver
uniprot_sec
Q8CD18
resolver
uniprot_sec
Q8R1J0
resolver
uniprot_sec
Q9CWV2
resolver
amino_acid_sequence
MATPVVTKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFDVVLVNWGKVADLAICNDQLIGVAFSQSNVSSYVVDLTRVTRTGTVTQDPVQANQPLTQQTPNPGVSLRRIYERPSTTCSKPQRVKHNSESERRSPSSEDDRDERESRAEIQNAEDYNEIFQPKNSISRTPPRRSEPFPAPPEDDAATVKEVSKPSPAMDVQLPQLPVPNLEVPARPSVMTSTPAPKGEPDIIPATRNEPIGLKASDFLPAVKVPQQAELVDEDAMSQIRKGHDTMFVVLTSRHKNLDTVRAVWTTGDIKTSVDSAVAINDLSVVVDLLNIVNQKASLWKLDLCTTVLPQIEKLLQSKYESYVQTGCTSLKLILQRFLPLITDILAAPPSVGVDISREERLHKCRLCFKQLKSISGLVKSKSGLSGRHGSAFRELHLLMASLD
uniprot
proteins
function
FUNCTION: Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. The function in regulating microtubule dynamics at spindle poles seems to depend on the association of the katanin KATNA1:KATNB1 complex with ASPM which recruits it to microtubules. Reversely KATNA1:KATNB1 can enhance ASPM blocking activity on microtubule minus-end growth. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. {ECO:0000255|HAMAP-Rule:MF_03022, ECO:0000269|PubMed:28436967}.
uniprot
proteins
mass_dalton
72639
uniprot
proteins
mutagenesis
MUTAGEN 538; /note="S->L: Disrupts KATNA1:KATNB1 interaction with ASPM."; /evidence="ECO:0000269|PubMed:28436967"; MUTAGEN 574; /note="Y->A: Disrupts KATNA1:KATNB1 interaction with ASPM; abolishes localization to microtubules minus ends; decreases ASPM localization to microtubules minus ends; no enhancement of ASPM activity in blocking microtubule minus-end growth."; /evidence="ECO:0000269|PubMed:28436967"; MUTAGEN 607; /note="G->A: Abolishes localization to microtubules."; /evidence="ECO:0000269|PubMed:28436967"; MUTAGEN 608; /note="V->A: Abolishes localization to microtubules."; /evidence="ECO:0000269|PubMed:28436967"; MUTAGEN 609; /note="D->A: Abolishes localization to microtubules."; /evidence="ECO:0000269|PubMed:28436967"; MUTAGEN 610; /note="I->A: Abolishes localization to microtubules."; /evidence="ECO:0000269|PubMed:28436967"; MUTAGEN 615; /note="R->A: Abolishes localization to microtubules minus ends; decreases ASPM localization to microtubules minus ends; no enhancement of ASPM activity in blocking microtubule minus-end growth."; /evidence="ECO:0000269|PubMed:28436967"; MUTAGEN 618; /note="K->A: Abolishes localization to microtubules."; /evidence="ECO:0000269|PubMed:28436967
uniprot
proteins
protein_family
WD repeat KATNB1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16203747
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25521379
uniprot
proteins
pubmed
28436967
uniprot
proteins
sequence_length
658
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03022}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP-Rule:MF_03022}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000255|HAMAP-Rule:MF_03022}. Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03022}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9BVA0}. Note=Predominantly cytoplasmic. Localized to the interphase centrosome and mitotic spindle poles (By similarity). Localizes within the cytoplasm, partially overlapping with microtubules, in interphase and to the mitotic spindle and spindle poles during mitosis (By similarity). {ECO:0000250|UniProtKB:Q9BVA0, ECO:0000255|HAMAP-Rule:MF_03022}.
uniprot
proteins