Il4r
entrez
25084
canonical
uniprot
Q63257
canonical
ensembl
ENSRNOG00000015441
resolver
ensembl
ENSRNOG00055030626
resolver
ensembl
ENSRNOG00060032143
resolver
ensp
ENSRNOP00000020994
resolver
ensp
ENSRNOP00000073767
resolver
genesymbol
Il4r
resolver
genesymbol_syn
Il4ra
resolver
uniprot
Q9R1W8
resolver
uniprot
Q9WTM8
resolver
uniprot_entry
IL4RA_RAT
resolver
uniprot_sec
Q9R1W8
resolver
uniprot_sec
Q9WTM8
resolver
amino_acid_sequence
MGWLCTKFLSSVSCLILLWVTGSGGIKVLGDPTCFSDYIRTSTCEWQLDSTVDCSSQLLLDYRLLFEFSENLTCTPKNSADTVCVCQMAIEEPIQADTYWLELWSERGQLWQGSFKPSDNVKPPAPDNLTLHTNVSNALLLMWSNPYPSNNFLHKGLICMVNISREDNPAEFKVYNVTYTEPKLSFPVNTLTSGVRYRARVRVLSQSFPGIWSEWSPSITWYNHFQLPLLQRLPLGVSISCICILLFCLTCYFSIIKIKKIWWDQIPTPARSPLAAIIIQDTKVSLWEKQTRSQESTKSRHWKTCLTKLLPCLLEHRVKKERESPKAAKTKPLQSPEKAGWYPAEVSRTVLWPENVHVSVVRCMELFEAPVQNVEEEEDEMVKGDLSMSPENSGGGFQESQADIMARLTENLFSDLLGAENGGVGQSSMAESSSLLPSESGQASTSWACFPTGPSETTCQVTGQQPPHPDPERATGTACTQVPLVISDNPAYRSFSDFSSPAPNPGELASEQKQAGHLEEGDLLSPVDPHSSGPPMQQAESWEQILHMSVLQHGTAGSTPAPTSGYQEFVQAVKQGASQDAGVPGVGPSGDTGYKAFSSLLSSSGVCTDTAAAGTDSGCGGYKPFQNPVPNQSPNSMPLFTFGLDMELPPSPLNSAPPNSTPECLGLELGLKGGTWLKAPPPSEQVPKPFGDDLGLGIVYSSLTCHLCGHLKQHHSQEEDGQIHVVASPGCGCCYDEKSPSLGNLSGTLESCPGEMSQEANLTLAPRTPSNLSGVGKGPGHSPVPSQTTEVPVGTLGVTVS
uniprot
proteins
function
FUNCTION: Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity). {ECO:0000250}.; FUNCTION: Isoform 2 (soluble form) inhibits IL4-induced spleen cell proliferation.
uniprot
proteins
mass_dalton
86719
uniprot
proteins
post_translational_modification
PTM: On IL4 binding, phosphorylated on C-terminal tyrosine residues. {ECO:0000250}.
uniprot
proteins
protein_family
Type 4 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
10525162
uniprot
proteins
pubmed
7640343
uniprot
proteins
sequence_length
801
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 233..256; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins