Arhgef40
entrez
268739
canonical
uniprot
Q3UPH7
canonical
ensembl
ENSMUSG00000004562
resolver
ensp
ENSMUSP00000091331
resolver
ensp
ENSMUSP00000098204
resolver
ensp
ENSMUSP00000138128
resolver
ensp
ENSMUSP00000138635
resolver
ensp
ENSMUSP00000207314
resolver
ensp
ENSMUSP00000207315
resolver
ensp
ENSMUSP00000207317
resolver
ensp
ENSMUSP00000207325
resolver
ensp
ENSMUSP00000207326
resolver
ensp
ENSMUSP00000207332
resolver
genesymbol
Arhgef40
resolver
genesymbol_syn
Solo
resolver
uniprot
Q3U1X1
resolver
uniprot
Q3UGT7
resolver
uniprot
Q3UYX3
resolver
uniprot
Q6KAS1
resolver
uniprot
Q6PD04
resolver
uniprot
Q6PDY3
resolver
uniprot_entry
ARH40_MOUSE
resolver
uniprot_sec
Q3U1X1
resolver
uniprot_sec
Q3UGT7
resolver
uniprot_sec
Q3UYX3
resolver
uniprot_sec
Q6KAS1
resolver
uniprot_sec
Q6PD04
resolver
uniprot_sec
Q6PDY3
resolver
amino_acid_sequence
MEPEPVEDCVQSTLAALYPPFEATAPTLLGQVFQVVERTYQEDALRYTLDFLVPAKHLLAKVQQEACAQYSGFLFFHEGWPLCLHEQVVVQLAALPWQLLRPGDFYLQVVPSAAQAPRLALKCLAPGGGRVQELPVPSEACAYLFTPEWLQGINKDRPTGRLSTCLLSAPSGIQRLPWAELVCPRFVHKEGLMVGHQPSTLPPELPSGPPGLPSSPLPEEVLGTRSPGDGHNAPAEGPEGEYVELLEVTLPVRGSPVDAEASGLSRTRTVPARKSTGGKGRHRRHRAWMNQKGLGSRDQDGTRPPGEGSSTGASSDSPSGAEADPDATALQASEPPAEALGEAPESCLLSGEAVGGVGQGAEGPPGTPRRTGKGNRRKKRAAGRGAGSRGGEGTSLSPRDKEETRQQEVLVSLPSPSEQEPAECSLVKEKEDSGKQESESKEELKPADEKEPARPEDYEPPEEEIRESEKEELTPQCTAGSTGPEWFPSEPSTQPLETVQNVKGDSLPEETPPVSVLDDPVVAWDLMASGFFVLTGGVDQTGRALLTITPPPPCLPEESSPSQETLSTALRYLHSLLRPDLQLLGLTILLDLRKAPPLPPALLPALSQLQDSGEPPLIQRLVILIHEDPPAELCGFQGAELLSEKDLKRVAKPEELQWDLGGHRDLSPNHWAEIHQEVARLCTLCQGVLTSVRQAIEELEGTAEPKEEEAVGMPEPLQKVLADPRLTALQRNGGAILMRLRSAHSSKLEGPGPAELYQEVDEAIHQLVRLSNLRVQQQEERQRLRQVQQVLQWLSGPGEEQLASFSMPGNSLSVLQETELRFRAFSTEVQERLVQAREALALEEDLTSQKVLDIFEQRLEQAESGLHRALRLQRFFQQAHEWVDEGSARLAGAGSGREALLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCRARCQELERRIQQQLGEEASPRSHRRRRADSASSAGAQHGAHSPSPSLSSLLLPSSPGPRAAPSHCSLTPCGEDYEEEGLELAPETDGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRAGGPDGPWGIGTPRMERKRSISAQQRLVSELIACEQEYVTTLNEPVPLPGPELTPELRCTWAAALSVRERLRSFHGTHFLQELQGCAAHPLRIGACFLRHGDQFNLYAQFVKHRHKLESGLAALTPSVKGSMESSPCLPRALQQPLEQLARYGQLLEELLREAGPELSSERQALRAAVQLLQEQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEDLLLFSKLKGSEGGSETFVYKQAFKTADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPETKLKWTSSIAQLLWRQAAHNKELRVQQMVSMGIGNKPFLDIKALGERTLSALLTGRAARTRASVAVSSFEHAGPSLPGLSPGACSLPARVEEEAWDLDVKQISLASETLDSSGDVSPGPRNSPSLQPPSPGSSTPALTSGGILGLSRQSHSRALSDPTTPL
uniprot
proteins
function
FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) for RHOA and RHOC (By similarity). Promotes actin stress fiber formation, force-induced stress fiber reinforcement and organization of KRT8/KRT18 networks via activation of RHOA/ROCK signaling, which is mediated by N-terminus KRT18 binding (By similarity). Regulates the formation or maintenance of properly elongated morphology of epithelial tubules, via mediation of the organization and orientation of KRT18 filaments (By similarity). Promotes RHOA-dependent, cell-cell contact mediated reorientation of endothelial cells and their actin stress fibers in response to mechanotransduction (By similarity). Positively regulates hemidesmosome formation via acting as a linker protein that anchors keratin filaments to hemidesmosomes (By similarity). Also required for JUP localization at cell-cell adhesion junctions (By similarity). {ECO:0000250|UniProtKB:A0A8I3PMN2, ECO:0000250|UniProtKB:Q8TER5}.
uniprot
proteins
mass_dalton
165132
uniprot
proteins
pubmed
15107133
uniprot
proteins
pubmed
15449545
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16143467
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1517
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8TER5}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8TER5}. Cell junction, hemidesmosome {ECO:0000250|UniProtKB:Q8TER5}. Cell junction {ECO:0000250|UniProtKB:Q8TER5}. Note=Concentrated in the perinuclear region (By similarity). Localizes to actin-based membrane ruffles (By similarity). Colocalizes with KRT8/KRT18 filament networks (By similarity). Localization to hemidesmosomes increases during mechanical force tension (By similarity). {ECO:0000250|UniProtKB:Q8TER5}.
uniprot
proteins