Pex1
entrez
71382
canonical
uniprot
Q5BL07
canonical
ensembl
ENSMUSG00000005907
resolver
ensp
ENSMUSP00000006061
resolver
ensp
ENSMUSP00000113304
resolver
ensp
ENSMUSP00000231658
resolver
genesymbol
Pex1
resolver
uniprot
Q3UEC7
resolver
uniprot
Q9CU85
resolver
uniprot_entry
PEX1_MOUSE
resolver
uniprot_sec
Q3UEC7
resolver
uniprot_sec
Q9CU85
resolver
amino_acid_sequence
MWSSDRLAGAGSGGAVVTVAFTNARDCFLHLPRRLVAQLHLLQNQAIEVASDHQPTYLSWVEGRHFNDQSENVAEINRQVGQKLGLSSGDQVFLRPCSHVVSCQQVEVEPLSADDWEILELHAISLEQHLLDQIRIVFPKAVVPIWVDQQTYIFIQIVTLMPAAPYGRLETNTKLLIQPKTRQAKESTFPKEGDAHGQVHSYGREQKGLSKELQTRQLHTNSEGITASNGRDPKVPGGPLKPSWWAVLGSMLSFGPDSKQESAWGSLELGAFKNMQSQAAPLEGTFRVCQVQPPSARTTTATSVFHKHCTAHVFPWDQEYFDVEPSFTVTYGKLVKLHSPKQQQDKSKQGVLLPDKEKQLSKSPDHKQISSNRSEEAAEACVLKVVWNGLEELKNATEFTESLELLHRGKVWIPDDLRKRLNIEMHAVVRITPLETTPKIPRSLKLQPRENLPKDVNEETIKTVFSSWVQQSATTMLPLVISKEERIKLEIKDGLREFSLSTVHSQEKEKEEGKTVFVLSSILLQKISVQVLLEPMIKEEQSAEIDFLLPSLTLSSLGGVSALGASAMEHITHSLLGRPLSRQLMALVAGLRNGALLITGGKGSGKSTFAKAICKEAQDTLDARVETVDCKALRGKRLESIQKALEVAFSEAAWRQPSVILLDDLDLIAGLPSVPEQEHSPEAVQSQRLAHALNDMIKEFVSTGSLVALIATSQLQQSLHPSLVSAQGIHTFQCVQHLQPPNPEQRCEILHSVVKNKLGCDISNFPDLDLQCIAKDTEAFVARDFTVLVDRAIHSSLSRQHSSSREDLTLTTSDFQKALRGFLPASLRNVNLHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVVARESGMNFISIKGPELLSKYIGASEQAVRDVFIRAQAAKPCILFFDEFESIAPRRGHDNTGVTDRVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILTVLSKSLALADDVDLQHVASVTDSFTGADLKALLYNAQLEALQGRLLPSGLPDGGSSSDSDLSLSSMVFLNHSSGSDDSAGDGECGLEQSLLSLEMSEILPDESKFNMYRLYFGSSYESELGNGTPSDLSSHCLSAPSSVTQDLPAAPGKDPLFTQHPVFRTPSQEGCQDLTQEQRDQLRAEISIIKGRYRSQSGEDESLNQPGPIKTTFAISQAHLMTALAHTRPSISEDEGKEFAELYENFQNPKKRKNQSGTVFRTGQKVTLA
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-11', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5. {ECO:0000250|UniProtKB:O43933}.
uniprot
proteins
mass_dalton
141428
uniprot
proteins
mutagenesis
MUTAGEN 135; /note="R->A: Loss of phospholipid-binding."; /evidence="ECO:0000269|PubMed:17018057"; MUTAGEN 174; /note="K->A: No effect on phospholipid-binding."; /evidence="ECO:0000269|PubMed:17018057
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
pubmed
15328346
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17018057
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1284
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O43933}. Peroxisome membrane {ECO:0000250|UniProtKB:O43933}. Note=Associated with peroxisomal membranes; anchored by PEX26 to peroxisome membranes. {ECO:0000250|UniProtKB:O43933}.
uniprot
proteins