Agxt2
entrez
268782
canonical
uniprot
Q3UEG6
canonical
ensembl
ENSMUSG00000089678
resolver
ensp
ENSMUSP00000022858
resolver
ensp
ENSMUSP00000106171
resolver
ensp
ENSMUSP00000216315
resolver
enst
ENSMUST00000022858
resolver
enst
ENSMUST00000110542
resolver
genesymbol
Agxt2
resolver
uniprot
B7ZP16
resolver
uniprot
B9EIZ8
resolver
uniprot
H7BWY3
resolver
uniprot_entry
AGT2_MOUSE
resolver
uniprot_entry
B7ZP16_MOUSE
resolver
uniprot_entry
H7BWY3_MOUSE
resolver
uniprot_sec
B9EIZ8
resolver
activity_regulation
ACTIVITY REGULATION: (R)-3-amino-2-methylpropionate--pyruvate transaminase and beta-alanine-pyruvate aminotransferase are inhibited by aminooxyacetic acid. {ECO:0000269|PubMed:27062388}.
uniprot
proteins
amino_acid_sequence
MSLAWRNLQKPFYLETSLRILQMRPSLSLGASRIAVPKLTLHTKHSMPPCDFSPEKYQSLAYSRVLAIHKQHLSPVDTAYFRKPLLLHQGHMEWLFDSEGNRYLDFFSGIVTVSVGHCHPKVSAVAKKQIDRLWHTSSVFFHSPMHEYAEKLSALLPEPLKVIFLVNSGSEANDLAMVMARAHSNHTDIISFRGAYHGCSPYTLGLTNVGIYKMEVPGGIGCQSTMCPDVFRGPWGGIHCRDSPVQTVRDCSCAPDCCQAKERYIEQFKDTLNTSVATSIAGFFAEPIQGVNGVVQYPKEFLKEAFALVRERGGVCIADEVQTGFGRLGSHFWGFQTHDVLPDIVTMAKGIGNGFPMAAVVTTPEIAKSLAKRLLHFSTFGGNPLACAIGSAVLEVIEEENLQRNSQEVGTYMLLKFAKLRDEFDIVGDVRGKGLMVGIEMVQDKISRQPLPKTEVNQIHEDCKDMGLLVGRGGNFSQTFRIVPPMCVTKMEVDFAYEVFRAALIQHMERRAK
uniprot
proteins
ec_number
2.6.1.18
uniprot
proteins
ec_number
2.6.1.40
uniprot
proteins
ec_number
2.6.1.44
uniprot
proteins
function
FUNCTION: Multifunctional aminotransferase with a broad substrate specificity (PubMed:23023372, PubMed:23154179, PubMed:23280748, PubMed:27062388). Catalyzes the conversion of glyoxylate to glycine using alanine as the amino donor (By similarity). Catalyzes metabolism of not L- but the D-isomer of D-beta-aminoisobutyric acid to generate 2-methyl-3-oxopropanoate and alanine (PubMed:27062388). Catalyzes the transfer of the amino group from beta-alanine to pyruvate to yield L-alanine and 3-oxopropanoate (PubMed:27062388). Can metabolize NG-monomethyl-L-arginine (NMMA), asymmetric NG,NG-dimethyl-L-arginine (ADMA) and symmetric NG,N'G-dimethyl-L-arginine (SDMA) (PubMed:23023372, PubMed:23154179, PubMed:23280748). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (PubMed:23023372). {ECO:0000250|UniProtKB:Q64565, ECO:0000269|PubMed:23023372, ECO:0000269|PubMed:23154179, ECO:0000269|PubMed:23280748, ECO:0000269|PubMed:27062388}.
uniprot
proteins
mass_dalton
57115
uniprot
proteins
protein_family
Class-III pyridoxal-phosphate-dependent aminotransferase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23023372
uniprot
proteins
pubmed
23154179
uniprot
proteins
pubmed
23280748
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
27062388
uniprot
proteins
sequence_length
513
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9BYV1}.
uniprot
proteins