Q5NBY9
uniprot
Q5NBY9
canonical
amino_acid_sequence
MERVNDASCGPSGCYTYQVSRHSTEMLHNLNQQRKNGGRFCDVLLRVGDESFPAHRAVLAACSEYFESVFSAQLGDGGAADGGPADVGGAAAAPGGGAGGSRELEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIEICQEVIKQSNVQILVPPARADIMLFRPPGTSDLGFPLDMTNGAAMAANSNGIAGSMQPEEEAARATGAAIAGQASLPVLPGVDRLPMVAGPLSPQLLTSPFPNVASSAPPLTSKRGRGRPRKANLLDSMFGSPGGLREAGILPCGLCGKVFTDANRLRQHEAQHGVTSLQLGYIDLPPPRLGENGLPISEDPDGPRKRSRTRKQVACEICGKIFRDVYHLNRHKLSHSGEKPYSCPVCGLRFKRKDRMSYHVRSHDGSVGKPYICQSCGKGFSRPDHLNGHIKQVHTSERPHKCQTCNASFATRDRLRSHLACHEDKVPCQVCGKYLRAAYMADHLKKHSEGPSNFCSICNRGFSSASYLKVHVKTHHGVPLPQVSRHQEPILNGGAAFHCARTYGNKEGQKCSHQDLIESSDSYGDLSDASDLKTPEKQSANGSFSCDVAVPKNKMESDGEKKYPCPECGSFFRSKSYLNKHIQKVHVRALGGPLGDLGPALGSPFSPQQNMSLLESFGFQIVQSAFASSLVDPEVDQQPMGPEGK
uniprot
proteins
function
FUNCTION: Transcriptional regulator that plays a role in many biological processes such as embryogenesis, senescence, T-cell development or neurogenesis (PubMed:18241078, PubMed:22886576, PubMed:33898458). Interacts with the TP53 protein to control genes that are important in proliferation and in the DNA-damage response. Mechanistically, the interaction inhibits the DNA binding and transcriptional activity of TP53/p53 (By similarity). Part of the transcriptional network modulating regulatory T-cell development and controls the generation of the regulatory T-cell pool under homeostatic conditions (By similarity). {ECO:0000250|UniProtKB:Q9HBE1, ECO:0000269|PubMed:18241078, ECO:0000269|PubMed:22886576, ECO:0000269|PubMed:33898458}.
uniprot
proteins
mass_dalton
74119
uniprot
proteins
pubmed
18241078
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22886576
uniprot
proteins
pubmed
32496219
uniprot
proteins
pubmed
33898458
uniprot
proteins
sequence_length
687
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18241078}.
uniprot
proteins