Hps6
entrez
309446
canonical
uniprot
Q7M733
canonical
ensembl
ENSRNOG00065031742
resolver
ensp
ENSRNOP00065044958
resolver
enst
ENSRNOT00065054656
resolver
genesymbol
Hps6
resolver
uniprot_entry
HPS6_RAT
resolver
amino_acid_sequence
MKRAGTLRLLSDLSNFTGAARLRELLAGDPAILVRCSPDGRHLLLLRPPGSPAPQLLVAVRGPGLPLERAWSEGDPSPLDVFFVPWLARPALILVWESGLTEVWGVGMEPGWKLLQSTELCPDGGARVMAVAATRGRLVWCEERQPGVEDQPGQLSMAFNHCVCVKTLDTSGEAGTKLGCTHILLHHCPSFGLIASRKELFLVPTSTTWPGVAHVLLIWSPSKGKVIVAAPSLGLSHSKSLNPKQGDTWDFRTLLRGLPGFLSPREPLAVHTWAPSSQGLLLLDLKGKVSLVQCHGGTRTVGLLQEAPVGLQGSAALGTFHGTLACVLGSTLELLDMSSGRLLERKVLSTDRVHLLEPPAPGVKNEEDLETRGALRLLSALGLFCVCWEAPQGLEVPSDKDLVFEEACGYYQRRSLRGTQLTPEELRHNSMFRAPQALASILQGHLPPSALLTTLRAELRDYRSIEQLKAQLVAGDDEETGWTELAEHEVARLLRTHLTGDQLAQFNTIFQALPTAAWSATLQALQLQPDRSGRLRSQAPPDVWKKVLRAPTAGKEHPNGILPPFELLCQCLGQLEPQWLPPFVELAQQQGGPGWGAEGPSLPLYRRALSVLGEEGKRPEALELELLLGSGRPKAVLQAVRQLIKKEQWERALEAGLTLDSSSPLLRSEIFNLLLAEFAQHRRLDTHLPLLCRLCPPEVAPDELLLLLRTHLPDDAGATPFPEPGAEPGAEPPLTVGLVRALLEQTGAQGRSSGPVQSTFEDILWDSGTPPPTPPRGPMTTLQASDHPGQEAWGPSGQGLGAADVGVHS
uniprot
proteins
function
FUNCTION: May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules. Acts as a cargo adapter for the dynein-dynactin motor complex to mediate the transport of lysosomes from the cell periphery to the perinuclear region. Facilitates retrograde lysosomal trafficking by linking the motor complex to lysosomes, and perinuclear positioning of lysosomes is crucial for the delivery of endocytic cargos to lysosomes, for lysosome maturation and functioning. {ECO:0000250|UniProtKB:Q86YV9}.
uniprot
proteins
mass_dalton
87463
uniprot
proteins
pubmed
12548288
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19010779
uniprot
proteins
sequence_length
809
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000250|UniProtKB:Q86YV9}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q86YV9}. Early endosome membrane {ECO:0000250|UniProtKB:Q86YV9}. Lysosome membrane {ECO:0000250|UniProtKB:Q86YV9}.
uniprot
proteins