Ift20
entrez
55978
canonical
uniprot
Q61025
canonical
ensembl
ENSMUSG00000001105
resolver
ensp
ENSMUSP00000118015
resolver
genesymbol
Ift20
resolver
uniprot
Q5SYG9
resolver
uniprot
Q99M35
resolver
uniprot_entry
IFT20_MOUSE
resolver
uniprot_sec
Q5SYG9
resolver
uniprot_sec
Q99M35
resolver
amino_acid_sequence
MAKDILGEAGLHFDELNKLRVLDPEVTQQTVELKEECKDFVDKIGQFQKIVGGLIELVDQLAKEAENEKMKAIGARNLLKSIAKQREAQQQQLQALIAEKKTQLERYRVEYEALCKVEAEQNEFIDQFIFQK
uniprot
proteins
function
FUNCTION: Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium (PubMed:16775004). Regulates the ciliary platelet-derived growth factor receptor-alpha (PDGFRA) signaling pathway. Required for protein stability of E3 ubiquitin ligases CBL and CBLB that mediate ubiquitination and internalization of PDGFRA for proper feedback inhibition of PDGFRA signaling (PubMed:29237719). Essential for male fertility. Plays an important role in spermatogenesis, particularly spermiogenesis, when germ cells form flagella. May play a role in the transport of flagellar proteins ODF2 and SPAG16 to build sperm flagella and in the removal of redundant sperm cytoplasm (PubMed:27682589). Also involved in autophagy since it is required for trafficking of ATG16L and the expansion of the autophagic compartment (PubMed:24089209). {ECO:0000269|PubMed:16775004, ECO:0000269|PubMed:24089209, ECO:0000269|PubMed:27682589, ECO:0000269|PubMed:29237719}.
uniprot
proteins
mass_dalton
15237
uniprot
proteins
pubmed
11916979
uniprot
proteins
pubmed
12821668
uniprot
proteins
pubmed
15337773
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16775004
uniprot
proteins
pubmed
19112494
uniprot
proteins
pubmed
19253336
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19889948
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24089209
uniprot
proteins
pubmed
25243405
uniprot
proteins
pubmed
27682589
uniprot
proteins
pubmed
28619825
uniprot
proteins
pubmed
29237719
uniprot
proteins
pubmed
29690537
uniprot
proteins
pubmed
31637240
uniprot
proteins
pubmed
31816150
uniprot
proteins
pubmed
36756949
uniprot
proteins
pubmed
38038747
uniprot
proteins
sequence_length
132
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network {ECO:0000269|PubMed:16775004, ECO:0000269|PubMed:19253336, ECO:0000269|PubMed:19889948, ECO:0000269|PubMed:28619825}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:15337773}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:15337773, ECO:0000269|PubMed:16775004}. Cell projection, cilium {ECO:0000269|PubMed:25243405, ECO:0000269|PubMed:29237719, ECO:0000269|PubMed:31637240}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19889948, ECO:0000269|PubMed:28619825, ECO:0000269|PubMed:29690537}. Golgi apparatus {ECO:0000269|PubMed:29237719}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:31816150}. Cytoplasm {ECO:0000269|PubMed:29690537}. Note=Present at the centrosomes during the cell cycle and associated with the proximal portion of the mother centriole and the lateral aspect of the daughter centriole (PubMed:15337773). Associated with basal body at the base of primary cilia (PubMed:15337773). Detected in the Golgi apparatus of round spermatids and late spermatocytes (PubMed:19889948, PubMed:28619825). Also detected in the manchette of step 10-12 spermatids (PubMed:19889948, PubMed:28619825). In step 14 spermatids, found in the basal body of the sperm tail (PubMed:19889948). Localization in the manchette of elongating spermatids is dependent on SPAG17 (PubMed:29690537). {ECO:0000269|PubMed:15337773, ECO:0000269|PubMed:19889948, ECO:0000269|PubMed:28619825, ECO:0000269|PubMed:29690537}.
uniprot
proteins