Slc22a5
entrez
29726
canonical
uniprot
O70594
canonical
ensembl
ENSRNOG00000008432
resolver
ensembl
ENSRNOG00055025236
resolver
ensembl
ENSRNOG00060023559
resolver
ensembl
ENSRNOG00065005626
resolver
ensp
ENSRNOP00000011340
resolver
ensp
ENSRNOP00055035525
resolver
ensp
ENSRNOP00060033791
resolver
ensp
ENSRNOP00065005905
resolver
enst
ENSRNOT00055043532
resolver
enst
ENSRNOT00060040853
resolver
enst
ENSRNOT00065008386
resolver
genesymbol
Slc22a5
resolver
genesymbol_syn
Octn2
resolver
uniprot
Q9QWL0
resolver
uniprot_entry
S22A5_RAT
resolver
uniprot_sec
Q9QWL0
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by emetine, quinidine and verapamil. The IC(50) of emetine is 4.2 uM. Not inhibited by valproic acid. Transport of (R)-carnitine is stimulated by cholesterol in the plasma membrane. {ECO:0000250|UniProtKB:O76082}.
uniprot
proteins
amino_acid_sequence
MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFNGMSIVFLAGTPEHRCLVPHTVNLSSAWRNHSIPLETKDGRQVPQSCRRYRLATIANFSALGLEPGRDVDLEQLEQENCLDGWEYNKDVFLSTIVTEWDLVCKDDWKAPLTTSLFFVGVLMGSFISGQLSDRFGRKNVLFLTMGMQTGFSFLQLFSVNFEMFTVLFVLVGMGQISNYVAAFVLGTEILSKSIRIIFATLGVCIFYAFGFMVLPLFAYFIRDWRMLLLALTVPGVLCGALWWFIPESPRWLISQGRVKEAEVIIRKAAKFNGIVAPSTIFDPSELQDLNSKKPQSHHIYDLVRTRNIRIITIMSIILWLTISVGYFGLSLDTPNLHGDIYVNCFLLAAVEVPAYVLAWLLLQHLPRRYSISAALFLGGSVLLFIQLVPSELFYLSTALVMVGKFGITSAYSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFFPESFGAPLPDTIDQMLRVKGIKQWQIQSQTRTQKDGGESPTVLKSTAF
uniprot
proteins
function
FUNCTION: Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3. May also contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable). {ECO:0000269|PubMed:10454528, ECO:0000305|PubMed:17616214}.
uniprot
proteins
mass_dalton
62567
uniprot
proteins
protein_family
Major facilitator (TC 2.A.1) superfamily
uniprot
proteins
protein_family
Organic cation transporter (TC 2.A.1.19) family
uniprot
proteins
pubmed
10454528
uniprot
proteins
pubmed
17616214
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9541011
uniprot
proteins
pubmed
9792817
uniprot
proteins
sequence_length
557
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O76082}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O76082}. Apical cell membrane {ECO:0000250|UniProtKB:O76082}; Multi-pass membrane protein {ECO:0000255}. Basal cell membrane {ECO:0000250|UniProtKB:O76082}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..41; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 143..163; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 173..193; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 198..218; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 233..253; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 258..278; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 342..362; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 374..394; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 407..427; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 431..451; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 463..483; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 489..509; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins