Sod3
entrez
20657
canonical
uniprot
O09164
canonical
ensembl
ENSMUSG00000072941
resolver
ensp
ENSMUSP00000098768
resolver
enst
ENSMUST00000101208
resolver
genesymbol
Sod3
resolver
uniprot
Q542X9
resolver
uniprot_entry
Q542X9_MOUSE
resolver
uniprot_entry
SODE_MOUSE
resolver
amino_acid_sequence
MLAFLFYGLLLAACGSVTMSNPGESSFDLADRLDPVEKIDRLDLVEKIGDTHAKVLEIWMELGRRREVDAAEMHAICRVQPSATLPPDQPQITGLVLFRQLGPGSRLEAYFSLEGFPAEQNASNRAIHVHEFGDLSQGCDSTGPHYNPMEVPHPQHPGDFGNFVVRNGQLWRHRVGLTASLAGPHAILGRSVVVHAGEDDLGKGGNQASLQNGNAGRRLACCVVGTSSSAAWESQTKERKKRRRESECKTT
uniprot
proteins
ec_number
1.15.1.1
uniprot
proteins
function
FUNCTION: Secreted antioxidant enzyme that acts as the primary scavenger of superoxide radicals in the extracellular space, converting them to hydrogen peroxide and thereby protecting tissues from oxidative damage (PubMed:12933702, PubMed:15761197, PubMed:16371425). Also preserves nitric oxide bioavailability by preventing the formation of harmful peroxynitrite (PubMed:12933702). Stored in intracellular pre-formed vesicles of macrophages and neutrophils and released upon stimulation by inflammatory mediators (By similarity). {ECO:0000250|UniProtKB:P08294, ECO:0000269|PubMed:12933702, ECO:0000269|PubMed:15761197, ECO:0000269|PubMed:16371425}.
uniprot
proteins
mass_dalton
27392
uniprot
proteins
protein_family
Cu-Zn superoxide dismutase family
uniprot
proteins
pubmed
12933702
uniprot
proteins
pubmed
15761197
uniprot
proteins
pubmed
16371425
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9163733
uniprot
proteins
pubmed
9376114
uniprot
proteins
sequence_length
251
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000269|PubMed:12933702, ECO:0000269|PubMed:15761197}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:16371425}. Vesicle {ECO:0000250|UniProtKB:P08294}. Note=99% of SOD3/EC-SOD is anchored to heparan sulfate proteoglycans in the tissue interstitium, and 1% is located in the vasculature in equilibrium between the plasma and the endothelium (By similarity). In macrophages and neutrophiles, extracellular SOD2 in endocytosed and stored in intracellular vesicles (By similarity). {ECO:0000250|UniProtKB:P08294}.
uniprot
proteins