CLDN17
entrez
26285
canonical
uniprot
P56750
canonical
ensembl
ENSG00000156282
resolver
ensp
ENSP00000286808
resolver
enst
ENST00000286808
resolver
genesymbol
CLDN17
resolver
hgnc
HGNC:2038
resolver
uniprot
Q3MJB5
resolver
uniprot
Q6UY37
resolver
uniprot_entry
CLD17_HUMAN
resolver
uniprot_sec
Q3MJB5
resolver
uniprot_sec
Q6UY37
resolver
amino_acid_sequence
MAFYPLQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARVRLQCKFYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLLGTSGVLFILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGGGLLCGFCCCNRKKQGYRYPVPGYRVPHTDKRRNTTMLSKTSTSYV
uniprot
proteins
function
FUNCTION: Channel-forming tight junction protein with selectivity for anions, including chloride and hydrogencarbonate, and for solutes smaller than 9 Angstrom in diameter. In the kidney proximal tubule, may be involved in paracellular reabsorption of filtered anions. Does not affect water permeability. {ECO:0000269|PubMed:22402829, ECO:0000269|PubMed:26194246}.
uniprot
proteins
mass_dalton
24603
uniprot
proteins
mutagenesis
MUTAGEN 31; /note="R->E: Decreased transepithelial resistance and anion selectivity. Higher permeability to chloride, sodium and also to larger anions, including pyruvate, nitrate, and thiocyanate."; /evidence="ECO:0000269|PubMed:22402829"; MUTAGEN 44; /note="E->A: Decreased transepithelial resistance and anion selectivity."; /evidence="ECO:0000269|PubMed:22402829"; MUTAGEN 45; /note="R->A: Decreased transepithelial resistance, no effect on anion selectivity."; /evidence="ECO:0000269|PubMed:22402829"; MUTAGEN 48; /note="E->K,Q: Decreased transepithelial resistance and anion selectivity. Higher permeability to chloride, sodium and also to larger anions, including pyruvate, nitrate, and thiocyanate."; /evidence="ECO:0000269|PubMed:22402829"; MUTAGEN 56; /note="R->A: No effect on transepithelial resistance, nor on anion selectivity. Elevated permeabilities not only for chloride, but also for sodium and the larger anions, including pyruvate, nitrate and thiocyanate."; /evidence="ECO:0000269|PubMed:22402829"; MUTAGEN 56; /note="R->T: Decreased anion selectivity. Increased permeabilities not only for chloride, but also for sodium and thiocyanate. No effect on transepithelial resistance."; /evidence="ECO:0000269|PubMed:22402829"; MUTAGEN 59; /note="R->A: No effect on transepithelial resistance, nor on anion selectivity. Increased permeability for thiocyanate."; /evidence="ECO:0000269|PubMed:22402829"; MUTAGEN 61; /note="R->A: Decreased anion selectivity. No effect on transepithelial resistance."; /evidence="ECO:0000269|PubMed:22402829"; MUTAGEN 65; /note="K->A: Reduced channel formation ability. Increased transepithelial resistance. Loss of anion selectivity in favor of cation selectivity."; /evidence="ECO:0000269|PubMed:22402829"; MUTAGEN 65; /note="K->E: No effect on channel formation ability. Loss of anion selectivity in favor of cation selectivity. No effect on transepithelial resistance."; /evidence="ECO:0000269|PubMed:22402829"; MUTAGEN 65; /note="K->R: Strongly reduced channel formation ability. Increased transepithelial resistance. Loss of anion selectivity in favor of cation selectivity."; /evidence="ECO:0000269|PubMed:22402829"; MUTAGEN 68; /note="S->E: Increased transepithelial resistance. Loss of anion selectivity in favor of cation (sodium) selectivity."; /evidence="ECO:0000269|PubMed:22402829"; MUTAGEN 149; /note="Y->A: Increased transepithelial resistance. No effect on localization to cell-cell junctions."; /evidence="ECO:0000269|PubMed:22402829"; MUTAGEN 154; /note="H->A: Loss of anion selectivity. Strongly increased permeabilities not only for chloride, but also for sodium and the larger anions, including pyruvate, nitrate and thiocyanate. No effect on localization to cell-cell junctions."; /evidence="ECO:0000269|PubMed:22402829
uniprot
proteins
protein_family
Claudin family
uniprot
proteins
pubmed
10830953
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20375010
uniprot
proteins
pubmed
22402829
uniprot
proteins
pubmed
26194246
uniprot
proteins
pubmed
36008380
uniprot
proteins
sequence_length
224
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000269|PubMed:22402829, ECO:0000269|PubMed:26194246}. Basolateral cell membrane {ECO:0000269|PubMed:20375010}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 82..102; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 125..145; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 165..185; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins