TIPIN
entrez
54962
canonical
uniprot
Q9BVW5
canonical
ensembl
ENSG00000075131
resolver
ensp
ENSP00000261881
resolver
ensp
ENSP00000457406
resolver
ensp
ENSP00000521382
resolver
ensp
ENSP00000521383
resolver
ensp
ENSP00000582761
resolver
ensp
ENSP00000582762
resolver
ensp
ENSP00000582763
resolver
ensp
ENSP00000582764
resolver
ensp
ENSP00000582765
resolver
ensp
ENSP00000582766
resolver
ensp
ENSP00000582767
resolver
ensp
ENSP00000582769
resolver
ensp
ENSP00000582770
resolver
ensp
ENSP00000625761
resolver
ensp
ENSP00000625762
resolver
enst
ENST00000261881
resolver
enst
ENST00000851323
resolver
enst
ENST00000851324
resolver
enst
ENST00000912702
resolver
enst
ENST00000912703
resolver
enst
ENST00000912704
resolver
enst
ENST00000912705
resolver
enst
ENST00000912706
resolver
enst
ENST00000912707
resolver
enst
ENST00000912708
resolver
enst
ENST00000912710
resolver
enst
ENST00000912711
resolver
enst
ENST00000955702
resolver
enst
ENST00000955703
resolver
genesymbol
TIPIN
resolver
hgnc
HGNC:30750
resolver
uniprot
B2CW64
resolver
uniprot
B4DRF3
resolver
uniprot
Q9NWZ6
resolver
uniprot_entry
B4DRF3_HUMAN
resolver
uniprot_entry
TIPIN_HUMAN
resolver
uniprot_sec
B2CW64
resolver
uniprot_sec
Q9NWZ6
resolver
amino_acid_sequence
MLEPQENGVIDLPDYEHVEDETFPPFPPPASPERQDGEGTEPDEESGNGAPVRVPPKRTVKRNIPKLDAQRLISERGLPALRHVFDKAKFKGKGHEAEDLKMLIRHMEHWAHRLFPKLQFEDFIDRVEYLGSKKEVQTCLKRIRLDLPILHEDFVSNNDEVAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKLLSNSQTLGNDMLMNTPRAHTVEEVNTDEDQKEESNGLNEDILDNPCNDAIANTLNEEETLLDQSFKNVQQQLDATSRNITEAR
uniprot
proteins
function
FUNCTION: Plays an important role in the control of DNA replication and the maintenance of replication fork stability (PubMed:17102137, PubMed:23359676, PubMed:35585232). Important for cell survival after DNA damage or replication stress (PubMed:17116885). May be specifically required for the ATR-CHEK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light (PubMed:17296725). Forms a complex with TIMELESS and this complex regulates DNA replication processes under both normal and stress conditions, stabilizes replication forks and influences both CHEK1 phosphorylation and the intra-S phase checkpoint in response to genotoxic stress (PubMed:17102137, PubMed:17116885, PubMed:17296725, PubMed:23359676, PubMed:35585232). {ECO:0000269|PubMed:17102137, ECO:0000269|PubMed:17116885, ECO:0000269|PubMed:17296725, ECO:0000269|PubMed:23359676, ECO:0000269|PubMed:35585232}.
uniprot
proteins
mass_dalton
34555
uniprot
proteins
protein_family
CSM3 family
uniprot
proteins
pubmed
12875843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
17102137
uniprot
proteins
pubmed
17116885
uniprot
proteins
pubmed
17141802
uniprot
proteins
pubmed
17296725
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20139726
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23359676
uniprot
proteins
pubmed
28334766
uniprot
proteins
pubmed
31429579
uniprot
proteins
pubmed
34694004
uniprot
proteins
pubmed
34700328
uniprot
proteins
pubmed
35585232
uniprot
proteins
sequence_length
301
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17102137, ECO:0000269|PubMed:17141802}. Nucleus {ECO:0000269|PubMed:17116885, ECO:0000269|PubMed:17141802, ECO:0000269|PubMed:31429579}.
uniprot
proteins