Dnase1
entrez
25633
canonical
uniprot
P21704
canonical
ensembl
ENSRNOG00000006873
resolver
ensembl
ENSRNOG00055024422
resolver
ensembl
ENSRNOG00060009080
resolver
ensembl
ENSRNOG00065009562
resolver
ensp
ENSRNOP00000009283
resolver
ensp
ENSRNOP00055034211
resolver
ensp
ENSRNOP00060011877
resolver
ensp
ENSRNOP00065011514
resolver
enst
ENSRNOT00000009283
resolver
enst
ENSRNOT00055041974
resolver
enst
ENSRNOT00060015258
resolver
enst
ENSRNOT00065015317
resolver
genesymbol
Dnase1
resolver
genesymbol_syn
Dnl1
resolver
uniprot
Q5FVU6
resolver
uniprot_entry
DNAS1_RAT
resolver
uniprot_sec
Q5FVU6
resolver
amino_acid_sequence
MRYTGLMGILLTLVNLLQLAATLRIAAFNIRTFGDTKMSNATLSSYIVKILSRYDIAVVQEVRDTHLVAVGKLLDELNRDIPDNYRYIISEPLGRKSYKEQYLFVYRPSQVSVLDSYHYDDGCEPCGNDTFSREPAIVKFFSPYTEVREFAIVPLHSAPTEAVSEIDALYDVYLDVRQKWGLEDIMFMGDFNAGCSYVTSSQWSSIRLRTSPIFQWLIPDSADTTATSTHCAYDRIVVAGALLQAAVVPSSAVPFDFQAEYRLTNQMAEAISDHYPVEVTLRKT
uniprot
proteins
ec_number
3.1.21.1
uniprot
proteins
function
FUNCTION: Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:15796714, PubMed:8428592). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (PubMed:15796714). Among other functions, seems to be involved in cell death by apoptosis (PubMed:15796714, PubMed:8428592). Binds specifically to G-actin and blocks actin polymerization (By similarity). Together with DNASE1L3, plays a key role in degrading neutrophil extracellular traps (NETs) (By similarity). NETs are mainly composed of DNA fibers and are released by neutrophils to bind pathogens during inflammation (By similarity). Degradation of intravascular NETs by DNASE1 and DNASE1L3 is required to prevent formation of clots that obstruct blood vessels and cause organ damage following inflammation (By similarity). {ECO:0000250|UniProtKB:P00639, ECO:0000250|UniProtKB:P49183, ECO:0000269|PubMed:15796714, ECO:0000269|PubMed:8428592}.
uniprot
proteins
mass_dalton
32064
uniprot
proteins
protein_family
DNase I family
uniprot
proteins
pubmed
12036587
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15796714
uniprot
proteins
pubmed
2263485
uniprot
proteins
pubmed
8428592
uniprot
proteins
pubmed
9303433
uniprot
proteins
sequence_length
284
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P24855}. Zymogen granule {ECO:0000250|UniProtKB:P24855}. Nucleus envelope {ECO:0000250|UniProtKB:P24855}. Note=Secretory protein, stored in zymogen granules and found in the nuclear envelope. {ECO:0000250|UniProtKB:P24855}.
uniprot
proteins