LANCL2
entrez
55915
canonical
uniprot
Q9NS86
canonical
ensembl
ENSG00000132434
resolver
ensp
ENSP00000254770
resolver
enst
ENST00000254770
resolver
genesymbol
LANCL2
resolver
genesymbol_syn
GPR69B
resolver
genesymbol_syn
TASP
resolver
hgnc
HGNC:6509
resolver
uniprot
B2R8D4
resolver
uniprot
B3KTN5
resolver
uniprot
Q6NSL4
resolver
uniprot
Q8TCQ3
resolver
uniprot
Q9BSR1
resolver
uniprot_entry
B3KTN5_HUMAN
resolver
uniprot_entry
LANC2_HUMAN
resolver
uniprot_sec
B2R8D4
resolver
uniprot_sec
Q6NSL4
resolver
uniprot_sec
Q8TCQ3
resolver
uniprot_sec
Q9BSR1
resolver
amino_acid_sequence
MGETMSKRLKLHLGGEAEMEERAFVNPFPDYEAAAGALLASGAAEETGCVRPPATTDEPGLPFHQDGKIIHNFIRRIQTKIKDLLQQMEEGLKTADPHDCSAYTGWTGIALLYLQLYRVTCDQTYLLRSLDYVKRTLRNLNGRRVTFLCGDAGPLAVGAVIYHKLRSDCESQECVTKLLQLQRSVVCQESDLPDELLYGRAGYLYALLYLNTEIGPGTVCESAIKEVVNAIIESGKTLSREERKTERCPLLYQWHRKQYVGAAHGMAGIYYMLMQPAAKVDQETLTEMVKPSIDYVRHKKFRSGNYPSSLSNETDRLVHWCHGAPGVIHMLMQAYKVFKEEKYLKEAMECSDVIWQRGLLRKGYGICHGTAGNGYSFLSLYRLTQDKKYLYRACKFAEWCLDYGAHGCRIPDRPYSLFEGMAGAIHFLSDVLGPETSRFPAFELDSSKRD
uniprot
proteins
function
FUNCTION: Necessary for abscisic acid (ABA) binding on the cell membrane and activation of the ABA signaling pathway in granulocytes. {ECO:0000269|PubMed:19667068}.
uniprot
proteins
mass_dalton
50854
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="G->A: Loss of membrane localization and results in localization to the nucleus, particularly to the nucleoli."; /evidence="ECO:0000269|PubMed:16979580
uniprot
proteins
post_translational_modification
PTM: Myristoylated. Essential for membrane association. {ECO:0000269|PubMed:16979580}.
uniprot
proteins
protein_family
LanC-like protein family
uniprot
proteins
pubmed
11762191
uniprot
proteins
pubmed
12566319
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16979580
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19667068
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
450
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12566319}. Cytoplasm {ECO:0000269|PubMed:12566319}. Cell membrane {ECO:0000269|PubMed:12566319, ECO:0000269|PubMed:16979580}. Note=Localizes to the juxta-nuclear vesicles (PubMed:16979580). Associates with the cortical actin cytoskeleton (PubMed:16979580). Cholesterol depletion by methyl-beta-cyclodextrin causes partial dissociation from the cell membrane in vitro and an enhanced cell detachment from the matrix in vivo (PubMed:16979580). Membrane-association is important for the increased cellular sensitivity to an anticancer drug (adriamycin) (PubMed:16979580). {ECO:0000269|PubMed:16979580}.
uniprot
proteins