Pip4p1
entrez
364298
canonical
uniprot
Q5PPM8
canonical
ensembl
ENSRNOG00000009948
resolver
ensembl
ENSRNOG00055024302
resolver
ensembl
ENSRNOG00060029281
resolver
ensembl
ENSRNOG00065032066
resolver
ensp
ENSRNOP00000013225
resolver
ensp
ENSRNOP00000096185
resolver
ensp
ENSRNOP00055033988
resolver
ensp
ENSRNOP00060042275
resolver
ensp
ENSRNOP00065045427
resolver
enst
ENSRNOT00000013225
resolver
enst
ENSRNOT00000115002
resolver
enst
ENSRNOT00055041748
resolver
enst
ENSRNOT00060050826
resolver
enst
ENSRNOT00065055236
resolver
genesymbol
Pip4p1
resolver
genesymbol_syn
Tmem55b
resolver
uniprot
A0A8I6GLH6
resolver
uniprot_entry
A0A8I6GLH6_RAT
resolver
uniprot_entry
PP4P1_RAT
resolver
amino_acid_sequence
MAADGERSPLLSEAGDGGAGGNGLAGPGGSATGPGGGLTPSAPPYGAGKHAPPQAFPPFPEGHPAVLPGEDPPPYSPLTSPDSGSAPMITCRVCQSPINVEGKMHQHVVKCGVCNEATPIKNAPPGKKYVRCPCNCLLICKVTSQRIACPRPYCKRIINLGPVHPGPLSPEPQPMGVRVICGHCKNTFLWTEFTDRTLARCPHCRKVSSIGRRYPRKRCICCFLLGLLLAVTATGLAFGTWKPAQQYGGIYAAWAFVILLAVLCLGRALYWGCMKVSHPVQNFS
uniprot
proteins
ec_number
3.1.3.78
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (By similarity). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). Regulates lysosomal positioning by recruiting JIP4 to lysosomal membranes, thus inducing retrograde transport of lysosomes along microtubules (By similarity). Contributes to assembly of the V-ATPase complex in lipid rafts of the lysosomal membrane and to subsequent amino acid-dependent activation of mTORC1 (By similarity). May play a role in the regulation of cellular cholesterol metabolism (By similarity). {ECO:0000250|UniProtKB:Q86T03}.
uniprot
proteins
mass_dalton
29993
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
284
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250|UniProtKB:Q3TWL2}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:Q3TWL2}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q3TWL2}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q3TWL2}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 219..239; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 246..266; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins