Ptpmt1
entrez
66461
canonical
uniprot
Q66GT5
canonical
ensembl
ENSMUSG00000063235
resolver
ensp
ENSMUSP00000159390
resolver
enst
ENSMUST00000111461
resolver
genesymbol
Ptpmt1
resolver
genesymbol_syn
Plip
resolver
uniprot
Q3U926
resolver
uniprot
Q9CSJ8
resolver
uniprot
Q9D622
resolver
uniprot_entry
PTPM1_MOUSE
resolver
uniprot_entry
Q3U926_MOUSE
resolver
uniprot_sec
Q9CSJ8
resolver
uniprot_sec
Q9D622
resolver
amino_acid_sequence
MAASAWLEAGLARVLFYPTLLYTVFRGRVRGPAHRDWYHRIDHTVLLGALPLKNMTRRLVLDENVRGVITMNEEYETRFLCNTSKEWKKAGVEQLRLSTVDMTGVPTLANLHKGVQFALKYQALGQCVYVHCKAGRSRSATMVAAYLIQVHNWSPEEAIEAIAKIRSHISIRPSQLEVLKEFHKEITARAAKN
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.27
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) (PubMed:21641550, PubMed:21730175). PGP is an essential intermediate in the biosynthetic pathway of cardiolipin, a mitochondrial-specific phospholipid regulating the membrane integrity and activities of the organelle (PubMed:21641550). Has also been shown to display phosphatase activity toward phosphoprotein substrates, specifically mediates dephosphorylation of mitochondrial proteins, thereby playing an essential role in ATP production (By similarity). Has probably a preference for proteins phosphorylated on Ser and/or Thr residues compared to proteins phosphorylated on Tyr residues (By similarity). Probably involved in regulation of insulin secretion in pancreatic beta cells (By similarity). Prevents intrinsic apoptosis, by regulating mitochondrial membrane integrity (By similarity). {ECO:0000250|UniProtKB:P0C089, ECO:0000250|UniProtKB:Q8WUK0, ECO:0000269|PubMed:16039589, ECO:0000269|PubMed:21641550}.
uniprot
proteins
mass_dalton
21943
uniprot
proteins
mutagenesis
MUTAGEN 2..37; /note="Missing: Loss of mitochondrion localization."; /evidence="ECO:0000269|PubMed:16039589"; MUTAGEN 2..19; /note="Missing: Does not affect mitochondrion localization."; /evidence="ECO:0000269|PubMed:16039589"; MUTAGEN 73; /note="E->A: Fails to dephosphorylate PGP in vitro."; /evidence="ECO:0000269|PubMed:21730175"; MUTAGEN 76; /note="E->A: Fails to dephosphorylate PGP in vitro."; /evidence="ECO:0000269|PubMed:21730175"; MUTAGEN 101; /note="D->A: Fails to dephosphorylate PGP in vitro."; /evidence="ECO:0000269|PubMed:21730175"; MUTAGEN 132; /note="C->S: Fails to dephosphorylate PGP in vitro. Does not affect level of Akt phosphorylation."; /evidence="ECO:0000269|PubMed:15247229, ECO:0000269|PubMed:21641550, ECO:0000269|PubMed:21730175
uniprot
proteins
pathway_participation
PATHWAY: Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 2/2. {ECO:0000269|PubMed:21641550}.
uniprot
proteins
protein_family
Non-receptor class dual specificity subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
15247229
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16039589
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21641550
uniprot
proteins
pubmed
21730175
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
193
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:16039589}; Peripheral membrane protein {ECO:0000250|UniProtKB:P0C089}; Matrix side {ECO:0000250|UniProtKB:P0C089}.
uniprot
proteins