CAPZA1
entrez
829
canonical
uniprot
P52907
canonical
ensembl
ENSG00000116489
resolver
ensp
ENSP00000263168
resolver
ensp
ENSP00000574685
resolver
ensp
ENSP00000797917
resolver
enst
ENST00000263168
resolver
genesymbol
CAPZA1
resolver
hgnc
HGNC:1488
resolver
uniprot
Q53FQ6
resolver
uniprot
Q6FHD5
resolver
uniprot_entry
CAZA1_HUMAN
resolver
uniprot_sec
Q53FQ6
resolver
uniprot_sec
Q6FHD5
resolver
amino_acid_sequence
MADFDDRVSDEEKVRIAAKFITHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNMDQFTPVKIEGYEDQVLITEHGDLGNSRFLDPRNKISFKFDHLRKEASDPQPEEADGGLKSWRESCDSALRAYVKDHYSNGFCTVYAKTIDGQQTIIACIESHQFQPKNFWNGRWRSEWKFTITPPTAQVVGVLKIQVHYYEDGNVQLVSHKDVQDSLTVSNEAQTAKEFIKIIENAENEYQTAISENYQTMSDTTFKALRRQLPVTRTKIDWNKILSYKIGKEMQNA
uniprot
proteins
function
FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions (PubMed:22891260). Forms, with CAPZB, the barbed end of the fast growing ends of actin filaments in the dynactin complex and stabilizes dynactin structure. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules (By similarity). {ECO:0000250|UniProtKB:A0PFK5, ECO:0000269|PubMed:22891260}.
uniprot
proteins
mass_dalton
32923
uniprot
proteins
protein_family
F-actin-capping protein alpha subunit family
uniprot
proteins
pubmed
12470955
uniprot
proteins
pubmed
12480931
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19922875
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22891260
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24951542
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
30361697
uniprot
proteins
pubmed
9331217
uniprot
proteins
sequence_length
286
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:A0PFK5}.
uniprot
proteins