HABP2
entrez
3026
canonical
uniprot
Q14520
canonical
ensembl
ENSG00000148702
resolver
ensp
ENSP00000277903
resolver
ensp
ENSP00000443283
resolver
genesymbol
HABP2
resolver
genesymbol_syn
HGFAL
resolver
hgnc
HGNC:4798
resolver
uniprot
A8K467
resolver
uniprot
B7Z8U5
resolver
uniprot
F5H5M6
resolver
uniprot
O00663
resolver
uniprot_entry
HABP2_HUMAN
resolver
uniprot_sec
A8K467
resolver
uniprot_sec
B7Z8U5
resolver
uniprot_sec
F5H5M6
resolver
uniprot_sec
O00663
resolver
amino_acid_sequence
MFARMSDLHVLLLMALVGKTACGFSLMSLLESLDPDWTPDQYDYSYEDYNQEENTSSTLTHAENPDWYYTEDQADPCQPNPCEHGGDCLVHGSTFTCSCLAPFSGNKCQKVQNTCKDNPCGRGQCLITQSPPYYRCVCKHPYTGPSCSQVVPVCRPNPCQNGATCSRHKRRSKFTCACPDQFKGKFCEIGSDDCYVGDGYSYRGKMNRTVNQHACLYWNSHLLLQENYNMFMEDAETHGIGEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDVSACSAQDVAYPEESPTEPSTKLPGFDSCGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMPQGHFCGGALIHPCWVLTAAHCTDIKTRHLKVVLGDQDLKKEEFHEQSFRVEKIFKYSHYNERDEIPHNDIALLKLKPVDGHCALESKYVKTVCLPDGSFPSGSECHISGWGVTETGKGSRQLLDAKVKLIANTLCNSRQLYDHMIDDSMICAGNLQKPGQDTCQGDSGGPLTCEKDGTYYVYGIVSWGLECGKRPGVYTQVTKFLNWIKATIKSESGF
uniprot
proteins
disease_involvement
DISEASE: Thyroid cancer, non-medullary, 5 (NMTC5) [MIM:616535]: A form of non-medullary thyroid cancer (NMTC), a cancer characterized by tumors originating from the thyroid follicular cells. NMTCs represent approximately 95% of all cases of thyroid cancer and are classified into papillary, follicular, Hurthle cell, and anaplastic neoplasms. {ECO:0000269|PubMed:12578864, ECO:0000269|PubMed:26222560}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Cleaves the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly (PubMed:11217080). It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro-urokinase) to the active two chain form (PubMed:10754382, PubMed:11217080). Activates coagulation factor VII (Probable). May function as a tumor suppressor negatively regulating cell proliferation and cell migration (PubMed:26222560). {ECO:0000269|PubMed:10754382, ECO:0000269|PubMed:11217080, ECO:0000269|PubMed:26222560, ECO:0000305|PubMed:10754382}.
uniprot
proteins
mass_dalton
62672
uniprot
proteins
post_translational_modification
PTM: Proteolytic cleavage at Gly-23 or Met-27 can give rise to the 50 kDa heavy chain (HC) and cleavage at Arg-313 or Lys-319 can give rise to the 27 kDa light chain (LC) (PubMed:8827452). The HC can undergo further proteolytic cleavage giving rise to a 26 kDa fragment (PubMed:11379758). The LC can undergo further proteolytic cleavage at Arg-313 leading to a 17-kDa fragment and at Arg-480 leading to a 8-kDa fragment (PubMed:11379758). {ECO:0000269|PubMed:11379758, ECO:0000269|PubMed:8827452}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
10754382
uniprot
proteins
pubmed
11217080
uniprot
proteins
pubmed
11379758
uniprot
proteins
pubmed
12578864
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
26222560
uniprot
proteins
pubmed
8827452
uniprot
proteins
sequence_length
560
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8827452}. Note=Secreted as an inactive single-chain precursor and is then activated to a heterodimeric form.
uniprot
proteins