Rab3b
entrez
81755
canonical
uniprot
Q63941
canonical
ensembl
ENSRNOG00000008001
resolver
ensp
ENSRNOP00000010645
resolver
enst
ENSRNOT00000010645
resolver
genesymbol
Rab3b
resolver
uniprot
A0A8L2UIF6
resolver
uniprot
Q6P9W6
resolver
uniprot_entry
A0A8L2UIF6_RAT
resolver
uniprot_entry
Q6P9W6_RAT
resolver
uniprot_entry
RAB3B_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs) which prevent Rab-GDP dissociation. {ECO:0000250|UniProtKB:P20336}.
uniprot
proteins
amino_acid_sequence
MASVTDGNTGIRDASDQNFDYMFKLLIIGNSSVGKTSFLFRYADDTFTPAFVSTVGIDFKVKTVYRHEKRVKLQIWDTAGQERYRTITTAYYRGAMGFILMYDITNEESFNAVQDWATQIKTYSWDNAQVILVGNKCDMEEERVIPTEKGRLLAEQLGFDFFEASAKENISVRQAFERLVDAICDKMSDSMDTDPSVLGASKTTRLSDTPPLLQQNCSC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. {ECO:0000250|UniProtKB:P20337}.
uniprot
proteins
mass_dalton
24785
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Thr-86 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM and RAB GDP dissociation inhibitor GDI2. {ECO:0000250|UniProtKB:P20337}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10748113
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7508866
uniprot
proteins
pubmed
9245721
uniprot
proteins
pubmed
9252191
uniprot
proteins
sequence_length
219
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus {ECO:0000250|UniProtKB:Q9CZT8}. Note=Colocalizes with DRC4 in the Golgi apparatus. {ECO:0000250|UniProtKB:Q9CZT8}.
uniprot
proteins