Rab40b
entrez
217371
canonical
uniprot
Q8VHP8
canonical
ensembl
ENSMUSG00000025170
resolver
ensp
ENSMUSP00000101713
resolver
ensp
ENSMUSP00000309236
resolver
enst
ENSMUST00000106107
resolver
genesymbol
Rab40b
resolver
genesymbol_syn
Rab40B
resolver
uniprot
B1ATT4
resolver
uniprot
Q4VA07
resolver
uniprot_entry
B1ATT4_MOUSE
resolver
uniprot_entry
Q4VA07_MOUSE
resolver
uniprot_entry
RB40B_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000250|UniProtKB:P62820}.
uniprot
proteins
amino_acid_sequence
MSSLGSPVRAYDFLLKFLLVGDSDVGKGEILASLQDGAAESPYGHPAGIDHKTTTILLDGRRVKLQLWDTSGQGRFCTIFRSYSRGAQGVVLVYDIANRWSFDGINRWIKEIDEHAPGVPKILVGNRLHLAFKRQVPTEQAQAYAERLGVTFFEVSPLCNFNITESFTELARIVLLRHGMDRLWRPSKVLSLQELCCRAVVSCTPGHLVDKLPLPVALRSHLKSFSMASGLNTRMMHGRSYSLTANSSHKRNSFRKVRTIRPPQSPPRNCARNSCKIS
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: RAB40B small GTPase acts as substrate-recognition components of the ECS(RAB40B) E3 ubiquitin ligase complex which mediates the ubiquitination of target proteins. The Rab40 subfamily belongs to the Rab family that are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. As part of the ECS(RAB40B) complex, GTP-bound RAB40B promotes LIMA1/EPLIN ubiquitination and degradation, thereby regulating leading-edge actin dynamics during cell migration. As part of the ECS(RAB40B) complex, GTP-bound RAB40B also ubiquitinates RAP2A GTPase which promotes its localization to lamellipodia and activation to drive cell migration. The ECS(RAB40B) complex does not mediate canonical ubiquitin-dependent degradation of RAP2. RAB40B also binds TKS5/SH3PXD2A effector independently from ECS complex to promote invadopodia-mediated extracellular matrix degradation. {ECO:0000250|UniProtKB:Q12829}.
uniprot
proteins
mass_dalton
31063
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
sequence_length
278
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q12829}; Lipid-anchor {ECO:0000250|UniProtKB:Q12829}; Cytoplasmic side {ECO:0000250|UniProtKB:Q12829}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q12829}. Cell projection, lamellipodium membrane {ECO:0000250|UniProtKB:Q12829}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q12829}. Note=Mainly localized in the cytosol. A subpopulation is present at the lamellipodia, where it colocalizes with actin ruffles. Colocalized with RAP2A at the lamellipodia plasma membrane. {ECO:0000250|UniProtKB:Q12829}.
uniprot
proteins