HCLS1
entrez
3059
canonical
uniprot
P14317
canonical
ensembl
ENSG00000180353
resolver
ensp
ENSP00000320176
resolver
ensp
ENSP00000387645
resolver
enst
ENST00000428394
resolver
genesymbol
HCLS1
resolver
genesymbol_syn
HS1
resolver
hgnc
HGNC:4844
resolver
uniprot
B4DQ69
resolver
uniprot
E7EVW7
resolver
uniprot
Q53Y93
resolver
uniprot
Q6IBK9
resolver
uniprot
Q9UDK0
resolver
uniprot_entry
E7EVW7_HUMAN
resolver
uniprot_entry
HCLS1_HUMAN
resolver
uniprot_sec
B4DQ69
resolver
uniprot_sec
Q53Y93
resolver
uniprot_sec
Q6IBK9
resolver
uniprot_sec
Q9UDK0
resolver
amino_acid_sequence
MWKSVVGHDVSVSVETQGDDWDTDPDFVNDISEKEQRWGAKTIEGSGRTEHINIHQLRNKVSEEHDVLRKKEMESGPKASHGYGGRFGVERDRMDKSAVGHEYVAEVEKHSSQTDAAKGFGGKYGVERDRADKSAVGFDYKGEVEKHTSQKDYSRGFGGRYGVEKDKWDKAALGYDYKGETEKHESQRDYAKGFGGQYGIQKDRVDKSAVGFNEMEAPTTAYKKTTPIEAASSGTRGLKAKFESMAEEKRKREEEEKAQQVARRQQERKAVTKRSPEAPQPVIAMEEPAVPAPLPKKISSEAWPPVGTPPSSESEPVRTSREHPVPLLPIRQTLPEDNEEPPALPPRTLEGLQVEEEPVYEAEPEPEPEPEPEPENDYEDVEEMDRHEQEDEPEGDYEEVLEPEDSSFSSALAGSSGCPAGAGAGAVALGISAVAVYDYQGEGSDELSFDPDDVITDIEMVDEGWWRGRCHGHFGLFPANYVKLLE
uniprot
proteins
function
FUNCTION: Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.
uniprot
proteins
mass_dalton
54014
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by FES (By similarity). Phosphorylated by LYN, FYN and FGR after cross-linking of surface IgM on B-cells. Phosphorylation by LYN, FYN and FGR requires prior phosphorylation by SYK or FES. {ECO:0000250, ECO:0000269|PubMed:10066823, ECO:0000269|PubMed:7682714, ECO:0000269|PubMed:8611520}.
uniprot
proteins
pubmed
10066823
uniprot
proteins
pubmed
12522270
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2587259
uniprot
proteins
pubmed
7682714
uniprot
proteins
pubmed
8611520
uniprot
proteins
pubmed
8713105
uniprot
proteins
pubmed
9058808
uniprot
proteins
sequence_length
486
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:7682714}; Peripheral membrane protein {ECO:0000269|PubMed:7682714}. Cytoplasm {ECO:0000269|PubMed:7682714}. Mitochondrion {ECO:0000305|PubMed:7682714}.
uniprot
proteins