Parp10
entrez
671535
canonical
uniprot
Q8CIE4
canonical
ensembl
ENSMUSG00000063268
resolver
ensp
ENSMUSP00000075110
resolver
ensp
ENSMUSP00000129765
resolver
enst
ENSMUST00000075689
resolver
enst
ENSMUST00000165738
resolver
genesymbol
Parp10
resolver
uniprot
F6Z9X8
resolver
uniprot
Q3TLV7
resolver
uniprot
Q3U6C0
resolver
uniprot
Q8BSZ1
resolver
uniprot
Q8C8L6
resolver
uniprot
Q8R133
resolver
uniprot
Q8R1U9
resolver
uniprot_entry
PAR10_MOUSE
resolver
uniprot_sec
F6Z9X8
resolver
uniprot_sec
Q3TLV7
resolver
uniprot_sec
Q3U6C0
resolver
uniprot_sec
Q8BSZ1
resolver
uniprot_sec
Q8C8L6
resolver
uniprot_sec
Q8R133
resolver
uniprot_sec
Q8R1U9
resolver
amino_acid_sequence
MAEVEAGAALELRGLPPEIPDELITLYFENHRRSGGGLLLSWQRLGCGGVLIFQDPADAKRVLAQAEHRLHGVRLSLRPAPPRAPERVLLQHLPPGTSPLSLEQHVQALLGAAGHPVQTCHALASPRQDCALVQLSTPLSEAEVSALAEQARNLPLNGATVSLAWVPQTRAVRVVDSASPVDLLLLELYLENERRSGGGPLEGLRSLPGQLGTVISFQQWQVAERVLKQKHWLQGIELSLVPHYDVLEPEALAEGVSGRDHSATQESGVIGHAPTGTGGLAGALTMAVGSGEAPQQLGTLLRAGPVGAPGQALPVDSGSIRIQGSMGSTSPVDPVESSTELPEQVGPMASDSVGVQEQEGLGEVATGQEGLMGLVGTAMESVETGLESPGYGEMQKQEGLVEMVMSVEPGAVRYLQLYYEDLLASLEDVALFPLEGTDVTGFRLCGARAPCQAAQELLQSLLGSISCHTLNMKHPGSARFLLGVEGQHLLHRLEAQFQCVFGTEHLASATLDIDPERTDPTEALQVLHGHITGIDQESLRLEDVRELLATLESPHGGEDRVPLEMEKEKPGGPGETVVEQQEEIPTLEAEEEPVALSTGARGQLEEEATLQLAIHRSLESQSQVADQQEANALRRAMALSLLEAEEALDEDTGGEAQLVVHTSFEQDVDELNQALSNALEAHLREETVSLQGRMLPPELGARLERCHDVSATLRGDRVVLRGFGVQPARAARHLAALLVDPWDQNLTFPLEASKPNLSEQGLKEPLGRLEALEENSQEFQDVVRAFYSTLDAVHGRIRIVRVERVSHPLLQQQYQLHRERLMQSCQQRPVEQVLYHGTSESAVLDICAHGFNRSFCGRNGTLYGQGVYFAKRASLSVLDRYSPPNAEGYKAVFVAQVLTGDYGQGSRGLKAPPLRVSGQVLRYDSAVDCLQQPRIFVIFHDTQALPTHLITCKNILPGTP
uniprot
proteins
ec_number
2.4.2.-
uniprot
proteins
function
FUNCTION: ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity. Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA. {ECO:0000250|UniProtKB:Q53GL7}.
uniprot
proteins
mass_dalton
103679
uniprot
proteins
post_translational_modification
PTM: Stimulated through its phosphorylation by CDK2. Acquires CDK-dependent phosphorylation through late-G1 to S phase, and from prometaphase to cytokinesis in the nucleolar organizing regions. Phosphorylation is suppressed in growth-arrested cells. {ECO:0000250|UniProtKB:Q53GL7}.; PTM: Auto-mono-ADP-ribosylated on glutamate and lysine residues. {ECO:0000250|UniProtKB:Q53GL7}.
uniprot
proteins
protein_family
ARTD/PARP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
960
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8K3Y6}. Nucleus {ECO:0000250|UniProtKB:Q8K3Y6}. Note=Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner. {ECO:0000250|UniProtKB:Q8K3Y6}.
uniprot
proteins