Lgals1
entrez
16852
canonical
uniprot
P16045
canonical
ensembl
ENSMUSG00000068220
resolver
ensp
ENSMUSP00000086795
resolver
enst
ENSMUST00000089377
resolver
genesymbol
Lgals1
resolver
genesymbol_syn
Gbp
resolver
uniprot
P05163
resolver
uniprot
P11946
resolver
uniprot
P17601
resolver
uniprot
Q4FZH4
resolver
uniprot
Q99M27
resolver
uniprot
Q9D0X0
resolver
uniprot_entry
LEG1_MOUSE
resolver
uniprot_sec
P05163
resolver
uniprot_sec
P11946
resolver
uniprot_sec
P17601
resolver
uniprot_sec
Q4FZH4
resolver
uniprot_sec
Q99M27
resolver
uniprot_sec
Q9D0X0
resolver
amino_acid_sequence
MACGLVASNLNLKPGECLKVRGEVASDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNTKEDGTWGTEHREPAFPFQPGSITEVCITFDQADLTIKLPDGHEFKFPNRLNMEAINYMAADGDFKIKCVAFE
uniprot
proteins
function
FUNCTION: Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. Plays a negative role in Th17 cell differentiation via activation of the receptor CD69. {ECO:0000250|UniProtKB:P09382, ECO:0000269|PubMed:1986871}.
uniprot
proteins
mass_dalton
14866
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1638977
uniprot
proteins
pubmed
1986871
uniprot
proteins
pubmed
2025648
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2335567
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
2803247
uniprot
proteins
pubmed
3020551
uniprot
proteins
pubmed
3335026
uniprot
proteins
sequence_length
135
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P09382}. Cytoplasm {ECO:0000250|UniProtKB:P09382}. Secreted {ECO:0000250|UniProtKB:P09382}. Note=Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. {ECO:0000250|UniProtKB:P09382}.
uniprot
proteins