Dedd
entrez
21945
canonical
uniprot
Q9Z1L3
canonical
ensembl
ENSMUSG00000013973
resolver
ensp
ENSMUSP00000068419
resolver
ensp
ENSMUSP00000095075
resolver
ensp
ENSMUSP00000106930
resolver
ensp
ENSMUSP00000106931
resolver
ensp
ENSMUSP00000219376
resolver
ensp
ENSMUSP00000219377
resolver
ensp
ENSMUSP00000219378
resolver
ensp
ENSMUSP00000219379
resolver
ensp
ENSMUSP00000219380
resolver
ensp
ENSMUSP00000219389
resolver
ensp
ENSMUSP00000219390
resolver
ensp
ENSMUSP00000219393
resolver
ensp
ENSMUSP00000219394
resolver
ensp
ENSMUSP00000219396
resolver
ensp
ENSMUSP00000219397
resolver
ensp
ENSMUSP00000332918
resolver
ensp
ENSMUSP00000358360
resolver
enst
ENSMUST00000064950
resolver
enst
ENSMUST00000097467
resolver
enst
ENSMUST00000111299
resolver
enst
ENSMUST00000111300
resolver
genesymbol
Dedd
resolver
uniprot
Q3U001
resolver
uniprot
Q7TQH8
resolver
uniprot
Q9R227
resolver
uniprot_entry
DEDD_MOUSE
resolver
uniprot_entry
Q3U001_MOUSE
resolver
uniprot_sec
Q7TQH8
resolver
uniprot_sec
Q9R227
resolver
amino_acid_sequence
MAGLKRRASQVWPEERGEQEHGLYSLHRMFDIVGTHLTHRDVRVLSFLFVDVIDDHERGLIRNGRDFLLALERQGRCDESNFRQVLQLLRIITRHDLLPYVTLKKRRAVCPDLVDKYLEETSIRYVTPRALSDPEPRPPQPSKTVPPHYPVVCCPTSGSQMCSKRPARGRTTLGSQRKRRKSVTPDPKEKQTCDIRLRVRAEYCQHETALQGNVFSNKQDPLERQFERFNQANTILKSRDLGSIICDIKFSELTYLDAFWRDYINGSLLEALKGVFITDSLKQAVGHEAIKLLVNVDEEDYELGRQKLLRNLMLQALP
uniprot
proteins
function
FUNCTION: A scaffold protein that directs CASP3 to certain substrates and facilitates their ordered degradation during apoptosis. May also play a role in mediating CASP3 cleavage of KRT18. Regulates degradation of intermediate filaments during apoptosis. May play a role in the general transcription machinery in the nucleus and might be an important regulator of the activity of GTF3C3 (By similarity). Inhibits DNA transcription in vitro. {ECO:0000250, ECO:0000269|PubMed:9774341}.
uniprot
proteins
mass_dalton
36805
uniprot
proteins
post_translational_modification
PTM: Exists predominantly in a mono- or diubiquitinated form.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9774341
uniprot
proteins
sequence_length
318
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Translocated to the nucleus during CD95-mediated apoptosis where it is localized in the nucleoli. Following apoptosis induction, the mono and/or diubiquitination form increases and forms filamentous structures that colocalize with KRT8 and KRT18 intermediate filament network in simple epithelial cells (By similarity). {ECO:0000250}.
uniprot
proteins