CPLX3
entrez
594855
canonical
uniprot
Q8WVH0
canonical
ensembl
ENSG00000213578
resolver
ensp
ENSP00000378464
resolver
enst
ENST00000395018
resolver
genesymbol
CPLX3
resolver
hgnc
HGNC:27652
resolver
uniprot
A0A384N6F4
resolver
uniprot
D3DW66
resolver
uniprot
Q8TEM6
resolver
uniprot
Q9H818
resolver
uniprot_entry
A0A384N6F4_HUMAN
resolver
uniprot_entry
CPLX3_HUMAN
resolver
uniprot_sec
D3DW66
resolver
uniprot_sec
Q8TEM6
resolver
uniprot_sec
Q9H818
resolver
amino_acid_sequence
MAFMVKTMVGGQLKNLTGSLGGGEDKGDGDKSAAEAQGMSREEYEEYQKQLVEEKMERDAQFTQRKAERATLRSHFRDKYRLPKNETDESQIQMAGGDVELPRELAKMIEEDTEEEEEKASVLGQLASLPGLNLGSLKDKAQATLGDLKQSAEKCHVM
uniprot
proteins
function
FUNCTION: Complexin that regulates SNARE protein complex-mediated synaptic vesicle fusion (By similarity). Required for the maintenance of synaptic ultrastructure in the adult retina (By similarity). Positively regulates synaptic transmission through synaptic vesicle availability and exocytosis of neurotransmitters at photoreceptor ribbon synapses in the retina (By similarity). Suppresses tonic photoreceptor activity and baseline 'noise' by suppression of Ca(2+) vesicle tonic release and the facilitation of evoked synchronous and asynchronous Ca(2+) vesicle release (By similarity). {ECO:0000250|UniProtKB:Q8R1B5}.
uniprot
proteins
mass_dalton
17557
uniprot
proteins
post_translational_modification
PTM: Farnesylation mediates presynaptic targeting. {ECO:0000250|UniProtKB:Q8R1B5}.
uniprot
proteins
protein_family
Complexin/synaphin family
uniprot
proteins
pubmed
12880961
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15911881
uniprot
proteins
sequence_length
158
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Synapse {ECO:0000250|UniProtKB:Q8R1B5}. Cell membrane; Lipid-anchor {ECO:0000250|UniProtKB:Q8R1B5}. Note=Enriched at the synaptic terminal (By similarity). Localized at glycinergic synaptic contacts of AII amacrine cells with OFF cone bipolar cells in the OFF sublamina of the retina inner nuclear layer (By similarity). {ECO:0000250|UniProtKB:Q8R1B5}.
uniprot
proteins