CLCA4
entrez
22802
canonical
uniprot
Q14CN2
canonical
ensembl
ENSG00000016602
resolver
ensp
ENSP00000359594
resolver
genesymbol
CLCA4
resolver
genesymbol_syn
CaCC2
resolver
hgnc
HGNC:2018
resolver
uniprot
A8MQC9
resolver
uniprot
B7Z1Q5
resolver
uniprot
Q6UX81
resolver
uniprot
Q9UNF7
resolver
uniprot_entry
CLCA4_HUMAN
resolver
uniprot_sec
A8MQC9
resolver
uniprot_sec
B7Z1Q5
resolver
uniprot_sec
Q6UX81
resolver
uniprot_sec
Q9UNF7
resolver
amino_acid_sequence
MGLFRGFVFLLVLCLLHQSNTSFIKLNNNGFEDIVIVIDPSVPEDEKIIEQIEDMVTTASTYLFEATEKRFFFKNVSILIPENWKENPQYKRPKHENHKHADVIVAPPTLPGRDEPYTKQFTECGEKGEYIHFTPDLLLGKKQNEYGPPGKLFVHEWAHLRWGVFDEYNEDQPFYRAKSKKIEATRCSAGISGRNRVYKCQGGSCLSRACRIDSTTKLYGKDCQFFPDKVQTEKASIMFMQSIDSVVEFCNEKTHNQEAPSLQNIKCNFRSTWEVISNSEDFKNTIPMVTPPPPPVFSLLKISQRIVCLVLDKSGSMGGKDRLNRMNQAAKHFLLQTVENGSWVGMVHFDSTATIVNKLIQIKSSDERNTLMAGLPTYPLGGTSICSGIKYAFQVIGELHSQLDGSEVLLLTDGEDNTASSCIDEVKQSGAIVHFIALGRAADEAVIEMSKITGGSHFYVSDEAQNNGLIDAFGALTSGNTDLSQKSLQLESKGLTLNSNAWMNDTVIIDSTVGKDTFFLITWNSLPPSISLWDPSGTIMENFTVDATSKMAYLSIPGTAKVGTWAYNLQAKANPETLTITVTSRAANSSVPPITVNAKMNKDVNSFPSPMIVYAEILQGYVPVLGANVTAFIESQNGHTEVLELLDNGAGADSFKNDGVYSRYFTAYTENGRYSLKVRAHGGANTARLKLRPPLNRAAYIPGWVVNGEIEANPPRPEIDEDTQTTLEDFSRTASGGAFVVSQVPSLPLPDQYPPSQITDLDATVHEDKIILTWTAPGDNFDVGKVQRYIIRISASILDLRDSFDDALQVNTTDLSPKEANSKESFAFKPENISEENATHIFIAIKSIDKSNLTSKVSNIAQVTLFIPQANPDDIDPTPTPTPTPTPDKSHNSGVNISTLVLSVIGSVVIVNFILSTTI
uniprot
proteins
ec_number
3.4.-.-
uniprot
proteins
function
FUNCTION: May be involved in mediating calcium-activated chloride conductance.
uniprot
proteins
mass_dalton
101283
uniprot
proteins
post_translational_modification
PTM: The translation product is autoproteolytically cleaved by the metalloprotease domain in the endoplasmic reticulum into a N-terminal and a C-terminal products that remain physically associated with each other. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity. {ECO:0000250|UniProtKB:A8K7I4}.
uniprot
proteins
protein_family
CLCR family
uniprot
proteins
pubmed
10437792
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15490240
uniprot
proteins
pubmed
16012037
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16740002
uniprot
proteins
pubmed
18254958
uniprot
proteins
sequence_length
919
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Apical cell membrane {ECO:0000250}. Secreted {ECO:0000250}. Note=The C-terminus 30 kDa form is anchored to the membrane. The N-terminus 110 kDa form is released from the membrane triggered by an unknown stimulus. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 895..915; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins