PTGDR2
entrez
11251
canonical
uniprot
Q9Y5Y4
canonical
ensembl
ENSG00000183134
resolver
ensp
ENSP00000332812
resolver
enst
ENST00000332539
resolver
genesymbol
PTGDR2
resolver
genesymbol_syn
CRTH2
resolver
genesymbol_syn
DL1R
resolver
genesymbol_syn
GPR44
resolver
hgnc
HGNC:4502
resolver
uniprot
O94765
resolver
uniprot
Q4QRI6
resolver
uniprot_entry
PD2R2_HUMAN
resolver
uniprot_sec
O94765
resolver
uniprot_sec
Q4QRI6
resolver
amino_acid_sequence
MSANATLKPLCPILEQMSRLQSHSNTSIRYIDHAAVLLHGLASLLGLVENGVILFVVGCRMRQTVVTTWVLHLALSDLLASASLPFFTYFLAVGHSWELGTTFCKLHSSIFFLNMFASGFLLSAISLDRCLQVVRPVWAQNHRTVAAAHKVCLVLWALAVLNTVPYFVFRDTISRLDGRIMCYYNVLLLNPGPDRDATCNSRQVALAVSKFLLAFLVPLAIIASSHAAVSLRLQHRGRRRPGRFVRLVAAVVAAFALCWGPYHVFSLLEARAHANPGLRPLVWRGLPFVTSLAFFNSVANPVLYVLTCPDMLRKLRRSLRTVLESVLVDDSELGGAGSSRRRRTSSTARSASPLALCSRPEEPRGPARLLGWLLGSCAASPQTGPLNRALSSTSS
uniprot
proteins
function
FUNCTION: Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. {ECO:0000269|PubMed:11208866, ECO:0000269|PubMed:11535533, ECO:0000269|PubMed:17196174}.
uniprot
proteins
mass_dalton
43268
uniprot
proteins
mutagenesis
MUTAGEN 330; /note="D->A: 45% increases internalization of PTGDR2."; /evidence="ECO:0000269|PubMed:20035740"; MUTAGEN 331; /note="S->A: 45% increases internalization of PTGDR2."; /evidence="ECO:0000269|PubMed:20035740"; MUTAGEN 332; /note="E->A: 45% increases internalization of PTGDR2."; /evidence="ECO:0000269|PubMed:20035740"; MUTAGEN 333; /note="L->A: 45% increase in internalization of PTGDR2."; /evidence="ECO:0000269|PubMed:20035740"; MUTAGEN 347; /note="T->A: Decreases in PKC-induced internalization of PTGDR2."; /evidence="ECO:0000269|PubMed:20035740
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000269|PubMed:17207480}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10036181
uniprot
proteins
pubmed
11168006
uniprot
proteins
pubmed
11208866
uniprot
proteins
pubmed
11535533
uniprot
proteins
pubmed
12466225
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17196174
uniprot
proteins
pubmed
17207480
uniprot
proteins
pubmed
20035740
uniprot
proteins
pubmed
9973380
uniprot
proteins
sequence_length
395
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Internalized receptors colocalized with RAB11A. {ECO:0000269|PubMed:17207480}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..56; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 68..89; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 107..127; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 147..168; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 211..231; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 248..269; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 289..308; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins