PTPN12
entrez
5782
canonical
uniprot
Q05209
canonical
ensembl
ENSG00000127947
resolver
ensp
ENSP00000248594
resolver
ensp
ENSP00000392429
resolver
ensp
ENSP00000397991
resolver
ensp
ENSP00000720514
resolver
genesymbol
PTPN12
resolver
hgnc
HGNC:9645
resolver
uniprot
A4D1C5
resolver
uniprot
B4DKY2
resolver
uniprot
B4E105
resolver
uniprot
E9PBR5
resolver
uniprot
E9PEH9
resolver
uniprot
Q16130
resolver
uniprot
Q59FD6
resolver
uniprot
Q75MN8
resolver
uniprot
Q86XU4
resolver
uniprot_entry
B4E105_HUMAN
resolver
uniprot_entry
PTN12_HUMAN
resolver
uniprot_sec
A4D1C5
resolver
uniprot_sec
B4DKY2
resolver
uniprot_sec
E9PBR5
resolver
uniprot_sec
E9PEH9
resolver
uniprot_sec
Q16130
resolver
uniprot_sec
Q59FD6
resolver
uniprot_sec
Q75MN8
resolver
uniprot_sec
Q86XU4
resolver
amino_acid_sequence
MEQVEILRKFIQRVQAMKSPDHNGEDNFARDFMRLRRLSTKYRTEKIYPTATGEKEENVKKNRYKDILPFDHSRVKLTLKTPSQDSDYINANFIKGVYGPKAYVATQGPLANTVIDFWRMIWEYNVVIIVMACREFEMGRKKCERYWPLYGEDPITFAPFKISCEDEQARTDYFIRTLLLEFQNESRRLYQFHYVNWPDHDVPSSFDSILDMISLMRKYQEHEDVPICIHCSAGCGRTGAICAIDYTWNLLKAGKIPEEFNVFNLIQEMRTQRHSAVQTKEQYELVHRAIAQLFEKQLQLYEIHGAQKIADGVNEINTENMVSSIEPEKQDSPPPKPPRTRSCLVEGDAKEEILQPPEPHPVPPILTPSPPSAFPTVTTVWQDNDRYHPKPVLHMVSSEQHSADLNRNYSKSTELPGKNESTIEQIDKKLERNLSFEIKKVPLQEGPKSFDGNTLLNRGHAIKIKSASPCIADKISKPQELSSDLNVGDTSQNSCVDCSVTQSNKVSVTPPEESQNSDTPPRPDRLPLDEKGHVTWSFHGPENAIPIPDLSEGNSSDINYQTRKTVSLTPSPTTQVETPDLVDHDNTSPLFRTPLSFTNPLHSDDSDSDERNSDGAVTQNKTNISTASATVSAATSTESISTRKVLPMSIARHNIAGTTHSGAEKDVDVSEDSPPPLPERTPESFVLASEHNTPVRSEWSELQSQERSEQKKSEGLITSENEKCDHPAGGIHYEMCIECPPTFSDKREQISENPTEATDIGFGNRCGKPKGPRDPPSEWT
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172). Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248' (PubMed:27134172). {ECO:0000269|PubMed:17329398, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:27134172}.
uniprot
proteins
mass_dalton
88106
uniprot
proteins
mutagenesis
MUTAGEN 19; /note="S->E: Loss of phosphorylation site."; /evidence="ECO:0000269|PubMed:27134172"; MUTAGEN 36; /note="R->A: Decreases enzyme activity."; /evidence="ECO:0000269|PubMed:27134172"; MUTAGEN 63; /note="R->A: Decreases enzyme activity."; /evidence="ECO:0000269|PubMed:27134172"; MUTAGEN 64; /note="Y->A: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:27134172"; MUTAGEN 66; /note="D->A: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:27134172"; MUTAGEN 67; /note="I->A: Nearly abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:27134172"; MUTAGEN 199; /note="D->A: Abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:27134172"; MUTAGEN 200; /note="H->A: Decreases enzyme activity."; /evidence="ECO:0000269|PubMed:27134172"; MUTAGEN 270; /note="R->A: Decreases enzyme activity."; /evidence="ECO:0000269|PubMed:27134172"; MUTAGEN 278; /note="Q->A: Nearly abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:27134172
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by STK24/MST3 and this results in inhibition of its activity. {ECO:0000269|PubMed:17046825}.
uniprot
proteins
protein_family
Non-receptor class 4 subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
1472029
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17046825
uniprot
proteins
pubmed
17329398
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18559503
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27134172
uniprot
proteins
pubmed
7509295
uniprot
proteins
pubmed
8349645
uniprot
proteins
pubmed
8454633
uniprot
proteins
pubmed
9857189
uniprot
proteins
sequence_length
780
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P35831}. Cell junction, focal adhesion {ECO:0000269|PubMed:18559503}. Cell projection, podosome {ECO:0000250|UniProtKB:P35831}. Note=Partial translocation to focal adhesion sites may be mediated by interaction with SORBS2. {ECO:0000269|PubMed:18559503}.
uniprot
proteins