RAMP2
entrez
10266
canonical
uniprot
O60895
canonical
ensembl
ENSG00000131477
resolver
ensp
ENSP00000253796
resolver
genesymbol
RAMP2
resolver
hgnc
HGNC:9844
resolver
uniprot
A7L9S6
resolver
uniprot
K7EMD3
resolver
uniprot
Q8N1F2
resolver
uniprot_entry
RAMP2_HUMAN
resolver
uniprot_sec
A7L9S6
resolver
uniprot_sec
K7EMD3
resolver
uniprot_sec
Q8N1F2
resolver
amino_acid_sequence
MASLRVERAGGPRLPRTRVGRPAALRLLLLLGAVLNPHEALAQPLPTTGTPGSEGGTVKNYETAVQFCWNHYKDQMDPIEKDWCDWAMISRPYSTLRDCLEHFAELFDLGFPNPLAERIIFETHQIHFANCSLVQPTFSDPPEDVLLAMIIAPICLIPFLITLVVWRSKDSEAQA
uniprot
proteins
function
FUNCTION: Accessory protein that interacts with and modulates the function of G protein-coupled receptors including calcitonin gene-related peptide type 1 receptor (CALCRL) and calcitonin receptor (CALCR) (PubMed:9620797). Required for the transport of CALCRL to the plasma membrane (PubMed:9620797). Together with CALCRL, form a receptor complex for adrenomedullin/ADM (PubMed:22102369, PubMed:32296767, PubMed:9620797). Together with CALCR, act as a receptor complex for calcitonin/CT/CALC (PubMed:35324283). Together with CALCR, also act as a receptor complex for amylin/IAPP (PubMed:35324283). {ECO:0000269|PubMed:22102369, ECO:0000269|PubMed:32296767, ECO:0000269|PubMed:35324283, ECO:0000269|PubMed:9620797}.
uniprot
proteins
mass_dalton
19608
uniprot
proteins
protein_family
RAMP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
22102369
uniprot
proteins
pubmed
30115739
uniprot
proteins
pubmed
32296767
uniprot
proteins
pubmed
35324283
uniprot
proteins
pubmed
9620797
uniprot
proteins
sequence_length
175
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:32296767}; Single-pass type I membrane protein {ECO:0000269|PubMed:32296767}.
uniprot
proteins
transmembrane_region
TRANSMEM 144..165; /note="Helical"; /evidence="ECO:0000269|PubMed:32296767, ECO:0007744|PDB:6UUN
uniprot
proteins