Hpgd
entrez
15446
canonical
uniprot
Q8VCC1
canonical
ensembl
ENSMUSG00000031613
resolver
ensp
ENSMUSP00000034026
resolver
enst
ENSMUST00000034026
resolver
genesymbol
Hpgd
resolver
genesymbol_syn
Pgdh1
resolver
uniprot
Q61106
resolver
uniprot_entry
PGDH_MOUSE
resolver
uniprot_sec
Q61106
resolver
amino_acid_sequence
MHVNGKVALVTGAAQGIGKAFAEALLLHGAKVALVDWNLEAGVKCKAALDEQFEPQKTLFVQCDVADQKQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEQTLQINLVSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIIGFTRSAAMAANLMKSGVRLNVICPGFVDTPILESIEKEENMGQYIEYKDQIKAMMKFYGVLHPSTIANGLINLIEDDALNGAIMKITASKGIHFQDYDISPLLVKAPLTS
uniprot
proteins
ec_number
1.1.1.-
uniprot
proteins
ec_number
1.1.1.141
uniprot
proteins
ec_number
1.1.1.232
uniprot
proteins
function
FUNCTION: Catalyzes the NAD-dependent dehydrogenation (oxidation) of a broad array of hydroxylated polyunsaturated fatty acids (mainly eicosanoids and docosanoids, including prostaglandins, lipoxins and resolvins), yielding their corresponding keto (oxo) metabolites (By similarity) (PubMed:8950170). Decreases the levels of the pro-proliferative prostaglandins such as prostaglandin E2 (whose activity is increased in cancer because of an increase in the expression of cyclooxygenase 2) and generates oxo-fatty acid products that can profoundly influence cell function by abrogating pro-inflammatory cytokine expression. Converts resolvins E1, D1 and D2 to their oxo products, which represents a mode of resolvin inactivation. Resolvin E1 plays important roles during the resolution phase of acute inflammation, while resolvins D1 and D2 have a unique role in obesity-induced adipose inflammation (By similarity). {ECO:0000250|UniProtKB:P15428, ECO:0000269|PubMed:8950170}.
uniprot
proteins
mass_dalton
29181
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20448048
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8950170
uniprot
proteins
sequence_length
269
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins