GNL3L
entrez
54552
canonical
uniprot
Q9NVN8
canonical
ensembl
ENSG00000130119
resolver
ensp
ENSP00000338573
resolver
ensp
ENSP00000354091
resolver
ensp
ENSP00000501411
resolver
ensp
ENSP00000501441
resolver
ensp
ENSP00000501452
resolver
ensp
ENSP00000543463
resolver
ensp
ENSP00000543464
resolver
ensp
ENSP00000543465
resolver
ensp
ENSP00000543466
resolver
ensp
ENSP00000543468
resolver
ensp
ENSP00000594164
resolver
enst
ENST00000336470
resolver
enst
ENST00000360845
resolver
enst
ENST00000674225
resolver
enst
ENST00000674311
resolver
enst
ENST00000674498
resolver
enst
ENST00000873404
resolver
enst
ENST00000873405
resolver
enst
ENST00000873406
resolver
enst
ENST00000873407
resolver
enst
ENST00000873409
resolver
enst
ENST00000924105
resolver
genesymbol
GNL3L
resolver
hgnc
HGNC:25553
resolver
uniprot
Q05DU1
resolver
uniprot_entry
GNL3L_HUMAN
resolver
uniprot_entry
Q05DU1_HUMAN
resolver
amino_acid_sequence
MMKLRHKNKKPGEGSKGHKKISWPYPQPAKQNGKKATSKVPSAPHFVHPNDHANREAELKKKWVEEMREKQQAAREQERQKRRTIESYCQDVLRRQEEFEHKEEVLQELNMFPQLDDEATRKAYYKEFRKVVEYSDVILEVLDARDPLGCRCFQMEEAVLRAQGNKKLVLVLNKIDLVPKEVVEKWLDYLRNELPTVAFKASTQHQVKNLNRCSVPVDQASESLLKSKACFGAENLMRVLGNYCRLGEVRTHIRVGVVGLPNVGKSSLINSLKRSRACSVGAVPGITKFMQEVYLDKFIRLLDAPGIVPGPNSEVGTILRNCVHVQKLADPVTPVETILQRCNLEEISNYYGVSGFQTTEHFLTAVAHRLGKKKKGGLYSQEQAAKAVLADWVSGKISFYIPPPATHTLPTHLSAEIVKEMTEVFDIEDTEQANEDTMECLATGESDELLGDTDPLEMEIKLLHSPMTKIADAIENKTTVYKIGDLTGYCTNPNRHQMGWAKRNVDHRPKSNSMVDVCSVDRRSVLQRIMETDPLQQGQALASALKNKKKMQKRADKIASKLSDSMMSALDLSGNADDGVGD
uniprot
proteins
function
FUNCTION: Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP. {ECO:0000269|PubMed:16251348, ECO:0000269|PubMed:17034816, ECO:0000269|PubMed:19487455, ECO:0000269|PubMed:21132010}.
uniprot
proteins
mass_dalton
65573
uniprot
proteins
mutagenesis
MUTAGEN 9..10; /note="KK->AA: Loss of nucleolar localization; when associated with 34-A-A-35. Loss of nuclear location; when associated with 19-A-A-20."; /evidence="ECO:0000269|PubMed:17034816"; MUTAGEN 19..20; /note="KK->AA: Loss of nuclear location; when associated with 9-A-A-10. Loss of nuclear location; when associated with 34-A-A-35."; /evidence="ECO:0000269|PubMed:17034816"; MUTAGEN 34..35; /note="KK->AA: Loss of nucleolar localization; when associated with 9-A-A-10. Loss of nuclear location; when associated with 19-A-A-20."; /evidence="ECO:0000269|PubMed:17034816"; MUTAGEN 145..147; /note="RDP->AAA: Loss of GTP binding. Loss of nucleolar localization. No effect on nuclear localization."; /evidence="ECO:0000269|PubMed:17034816"; MUTAGEN 309..310; /note="PG->AA: Loss of nucleolar localization. No effect on nuclear localization."; /evidence="ECO:0000269|PubMed:17034816
uniprot
proteins
protein_family
TRAFAC class YlqF/YawG GTPase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
16251348
uniprot
proteins
pubmed
17034816
uniprot
proteins
pubmed
19487455
uniprot
proteins
pubmed
21132010
uniprot
proteins
pubmed
25114211
uniprot
proteins
sequence_length
582
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:17034816}.
uniprot
proteins