SEC13
entrez
6396
canonical
uniprot
P55735
canonical
ensembl
ENSG00000157020
resolver
ensp
ENSP00000312122
resolver
ensp
ENSP00000336566
resolver
ensp
ENSP00000373312
resolver
ensp
ENSP00000380298
resolver
ensp
ENSP00000671129
resolver
genesymbol
SEC13
resolver
genesymbol_syn
D3S1231E
resolver
genesymbol_syn
SEC13A
resolver
genesymbol_syn
SEC13L1
resolver
genesymbol_syn
SEC13R
resolver
hgnc
HGNC:10697
resolver
uniprot
A8MV37
resolver
uniprot
A8MWR8
resolver
uniprot
B4DXJ1
resolver
uniprot
Q5BJF0
resolver
uniprot
Q9BRM6
resolver
uniprot
Q9BUG7
resolver
uniprot_entry
A8MWR8_HUMAN
resolver
uniprot_entry
SEC13_HUMAN
resolver
uniprot_sec
A8MV37
resolver
uniprot_sec
B4DXJ1
resolver
uniprot_sec
Q5BJF0
resolver
uniprot_sec
Q9BRM6
resolver
uniprot_sec
Q9BUG7
resolver
activity_regulation
ACTIVITY REGULATION: The GATOR2 complex is negatively regulated by the upstream amino acid sensors CASTOR1 and SESN2, which sequester the GATOR2 complex in absence of amino acids (PubMed:25457612, PubMed:26972053, PubMed:27487210). In the presence of abundant amino acids, GATOR2 is released from CASTOR1 and SESN2 and activated (PubMed:25457612, PubMed:26972053, PubMed:27487210). {ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:26972053, ECO:0000269|PubMed:27487210}.
uniprot
proteins
amino_acid_sequence
MVSVINTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIWTCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKGQGSVSASVTEGQQNEQ
uniprot
proteins
function
FUNCTION: Functions as a component of the nuclear pore complex (NPC) and the COPII coat (PubMed:8972206). At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles (PubMed:8972206). Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum (By similarity). {ECO:0000250|UniProtKB:Q9D1M0, ECO:0000269|PubMed:8972206}.; FUNCTION: As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:23723238, PubMed:25457612, PubMed:27487210, PubMed:35831510, PubMed:36528027). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (PubMed:23723238, PubMed:27487210, PubMed:35831510, PubMed:36528027). GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 (PubMed:36528027). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (PubMed:36528027). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (PubMed:25457612, PubMed:26972053, PubMed:27487210). Within the GATOR2 complex, SEC13 and SEH1L are required to stabilize the complex (PubMed:35831510). {ECO:0000269|PubMed:23723238, ECO:0000269|PubMed:25457612, ECO:0000269|PubMed:26972053, ECO:0000269|PubMed:27487210, ECO:0000269|PubMed:35831510, ECO:0000269|PubMed:36528027}.
uniprot
proteins
mass_dalton
35541
uniprot
proteins
protein_family
WD repeat SEC13 family
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
14517296
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16495487
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
16957052
uniprot
proteins
pubmed
17428803
uniprot
proteins
pubmed
17499046
uniprot
proteins
pubmed
18160040
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19638414
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22355596
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23723238
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25201882
uniprot
proteins
pubmed
25263562
uniprot
proteins
pubmed
25457612
uniprot
proteins
pubmed
26972053
uniprot
proteins
pubmed
27487210
uniprot
proteins
pubmed
28199306
uniprot
proteins
pubmed
35831510
uniprot
proteins
pubmed
36528027
uniprot
proteins
pubmed
7987303
uniprot
proteins
pubmed
8972206
uniprot
proteins
pubmed
9110174
uniprot
proteins
sequence_length
322
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, COPII-coated vesicle membrane {ECO:0000269|PubMed:8972206}; Peripheral membrane protein {ECO:0000269|PubMed:8972206}; Cytoplasmic side {ECO:0000269|PubMed:8972206}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:8972206}; Peripheral membrane protein {ECO:0000269|PubMed:8972206}; Cytoplasmic side {ECO:0000269|PubMed:8972206}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:14517296, ECO:0000269|PubMed:18160040}. Lysosome membrane {ECO:0000269|PubMed:28199306}. Note=In interphase, localizes at both sides of the NPC. {ECO:0000269|PubMed:14517296}.
uniprot
proteins