Ttll13
entrez
269954
canonical
uniprot
A4Q9F6
canonical
ensembl
ENSMUSG00000045467
resolver
ensp
ENSMUSP00000062795
resolver
ensp
ENSMUSP00000145702
resolver
ensp
ENSMUSP00000265823
resolver
enst
ENSMUST00000058266
resolver
genesymbol
Ttll13
resolver
uniprot
Q8C0W9
resolver
uniprot_entry
TTL13_MOUSE
resolver
uniprot_sec
Q8C0W9
resolver
amino_acid_sequence
MEPNNCKTSESEEDDIEEEESEEECVREESTTPNSTQQALRKADYKEFENGVALSVVAKKIPKKILSATDTDDLEVGRRRRKRKRRPLAINLTNCKYESVRRAAQMCGLKEVGEDEEWTVYWTDCSVSLERVMDMKRFQKINHFPGMTEICRKDLLARNLNRMQKLYPTEYNIFPRTWCLPADYGDFQAYGRQRKTRTYICKPDSGCQGRGIFITRTPKEIKPGEHMICQQYITKPFLIDGFKFDMRIYVLITSCDPLRIFMYEEGLARFATMPYVEPSHNNLEEVCMHLTNYAINKHNENFVRDDAVGSKRKLSTLNAWLREHSHDPQELWGDIEDIIIKTIISAHSVLRHNYRTCFPQYLCGGTCACFEILGFDILLDHKLKPWLLEVNHSPSFTTDSRLDREVKDALLCDAMNLVNLRGCDKKKVIEEDKRRVKERLFPCHQQPRETRREQFELSQAAMHDQERYEDSHLGGYRRIYPGPDSEKYAPFFKHNGSLFQETAASKAREECARQQLEEIRLKQEQQENPGTKKRKENKEQNQGESAGEKSRSRTATRVLATSLAYRNRNREKELLPVQLDTTQPQDIVEEEELERMKLLLQRENLIRSLGIVEQLTRMLYPSHRSHRKLHEYRPRFHQDGLSSQELQPVNLVPLVLLRGAASEQIPPHFLQPLRPHELIPRILGPLSSINPAIAQHSRYHLQPKNFNWIGDSAATGPCSLSMKKSGRHYISSSRVRLTSRKRRKAQHSTKTANGLQSLLIERLPTSSRLKSSGQDLCLQKAKNTETPRVLQHSKILWGSVKTKR
uniprot
proteins
ec_number
6.3.2.-
uniprot
proteins
function
FUNCTION: Polyglutamylase which modifies tubulin, generating polyglutamate side chains of variable lengths on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin (PubMed:17499049). Mediates ATP-dependent polyglutamate side-chain elongation of the polyglutamylation reaction but not the initiation step (PubMed:17499049). Preferentially modifies the alpha-tubulin tail over a beta-tail (PubMed:17499049). Mediates spindle-pole microtubule glutamylation in a CFAP100-dependent manner, a modification necessary for maintaining spindle-pole integrity and ensuring proper spindle assembly (PubMed:40593606). {ECO:0000269|PubMed:17499049, ECO:0000269|PubMed:40593606}.
uniprot
proteins
mass_dalton
93463
uniprot
proteins
protein_family
Tubulin--tyrosine ligase family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17499049
uniprot
proteins
pubmed
23897886
uniprot
proteins
pubmed
40593606
uniprot
proteins
sequence_length
804
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:40593606}. Note=Localizes to the spindle pole in a CFAP100-dependent manner. {ECO:0000269|PubMed:40593606}.
uniprot
proteins