Nefl
entrez
18039
canonical
uniprot
P08551
canonical
ensembl
ENSMUSG00000022055
resolver
ensp
ENSMUSP00000022639
resolver
enst
ENSMUST00000022639
resolver
genesymbol
Nefl
resolver
genesymbol_syn
Nf68
resolver
genesymbol_syn
Nfl
resolver
uniprot
Q8K0Z0
resolver
uniprot_entry
NFL_MOUSE
resolver
uniprot_sec
Q8K0Z0
resolver
amino_acid_sequence
MSSFGYDPYFSTSYKRRYVETPRVHISSVRSGYSTARSAYSSYSAPVSSSLSVRRSYSSSSGSLMPSLENLDLSQVAAISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELLVLRQKHSEPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKGADEAALARAELEKRIDSLMDEIAFLKKVHEEEIAELQAQIQYAQISVEMDVSSKPDLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTLEIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRSTKSEMARYLKEYQDLLNVKMALDIEIAAYRKLLEGEETRLSFTSVGSITSGYSQSSQVFGRSAYSGLQSSSYLMSARSFPAYYTSHVQEEQTEVEETIEATKAEEAKDEPPSEGEAEEEEKEKEEGEEEEGAEEEEAAKDESEDTKEEEEGGEGEEEDTKESEEEEKKEESAGEEQVAKKKD
uniprot
proteins
function
FUNCTION: Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (PubMed:22723690). {ECO:0000269|PubMed:22723690}.
uniprot
proteins
mass_dalton
61508
uniprot
proteins
post_translational_modification
PTM: O-glycosylated. {ECO:0000269|PubMed:16452088}.; PTM: Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization. {ECO:0000250}.; PTM: Ubiquitinated in the presence of TRIM2 and UBE2D1. {ECO:0000269|PubMed:18687884}.
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16236762
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
16452088
uniprot
proteins
pubmed
1717455
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
18687884
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2246261
uniprot
proteins
pubmed
22723690
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
3103856
uniprot
proteins
pubmed
3785173
uniprot
proteins
pubmed
3919033
uniprot
proteins
sequence_length
543
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, axon {ECO:0000269|PubMed:22723690}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22723690}.
uniprot
proteins