Klhl25
entrez
293023
canonical
uniprot
Q4KLM4
canonical
ensembl
ENSRNOG00000010959
resolver
ensp
ENSRNOP00000014553
resolver
ensp
ENSRNOP00000089869
resolver
ensp
ENSRNOP00000090402
resolver
ensp
ENSRNOP00000097538
resolver
ensp
ENSRNOP00000099986
resolver
ensp
ENSRNOP00000102094
resolver
ensp
ENSRNOP00000110193
resolver
enst
ENSRNOT00000014553
resolver
enst
ENSRNOT00000097328
resolver
enst
ENSRNOT00000111640
resolver
enst
ENSRNOT00000112874
resolver
enst
ENSRNOT00000123188
resolver
enst
ENSRNOT00000158005
resolver
enst
ENSRNOT00000168304
resolver
genesymbol
Klhl25
resolver
uniprot_entry
KLH25_RAT
resolver
amino_acid_sequence
MSVSVHETRKSRSSTGSMNISVFHKASHPDCVLAHLNTLRKHCMFTDVTLWAGDRAFPCHRAVLAASSRYFEAMFSHGLRESRDDTVNFQDNLHPEVLELLLDFAYSSRIVINEENAESLLEAGDMLQFHDVRDAAAEFLEKNLSPSNCLGMMVLSDAHQCRRLYEFSCRMSLVHFETVRQSEDFNSLSRDTLLDLISRDELETEDERVVFEAILQWVKHDLEQRKVHLPLLLRNVRLALLPSDCLKKAVSGEALLMADECTKLIIDEAFRCKTKILLNDGVVTSPFARPRKAGHTLLILGGQTFMCDKIYQVDHKAKEIIPKADLPSPRKEFSASAIGCKVYVTGGRGSENGVSKDVWVYDTVHEEWSKAAPMLIARFGHGSAELENCLYVVGGHTSLAGIFPASPSVSLKQVEKYDPGDNKWTMVAPMRDGVSNAAVVSAKLKLFVFGGTSIHRDMVSKVQCFDPSDNRWTIKAECPQPWRYTAAAVLGSQIFIMGGDTEYTAASAYRFDCETNQWTRIGDMTAKRMSCHAVASGNKLYVVGGYFGTQRCKTLDCYDPTSDTWNCITSVPYSLIPTAFVSTWKHLPA
uniprot
proteins
function
FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex involved in various processes, such as translation homeostasis and lipid synthesis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E. The BCR(KLHL25) complex also acts as a regulator of lipid synthesis by mediating ubiquitination and degradation of ACLY, thereby inhibiting lipid synthesis. BCR(KLHL25)-mediated degradation of ACLY promotes fatty acid oxidation and is required for differentiation of inducible regulatory T (iTreg) cells. {ECO:0000250|UniProtKB:Q9H0H3}.
uniprot
proteins
mass_dalton
65840
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9H0H3}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
589
uniprot
proteins