LYPLAL1
entrez
127018
canonical
uniprot
Q5VWZ2
canonical
ensembl
ENSG00000143353
resolver
ensp
ENSP00000355894
resolver
ensp
ENSP00000355895
resolver
ensp
ENSP00000580217
resolver
ensp
ENSP00000580218
resolver
ensp
ENSP00000580219
resolver
ensp
ENSP00000580222
resolver
ensp
ENSP00000770467
resolver
genesymbol
LYPLAL1
resolver
hgnc
HGNC:20440
resolver
uniprot
A8K677
resolver
uniprot
Q5VWZ3
resolver
uniprot
Q7Z4A3
resolver
uniprot
Q96AV0
resolver
uniprot_entry
LYPL1_HUMAN
resolver
uniprot_sec
A8K677
resolver
uniprot_sec
Q5VWZ3
resolver
uniprot_sec
Q7Z4A3
resolver
uniprot_sec
Q96AV0
resolver
amino_acid_sequence
MAAASGSVLQRCIVSPAGRHSASLIFLHGSGDSGQGLRMWIKQVLNQDLTFQHIKIIYPTAPPRSYTPMKGGISNVWFDRFKITNDCPEHLESIDVMCQVLTDLIDEEVKSGIKKNRILIGGFSMGGCMAIHLAYRNHQDVAGVFALSSFLNKASAVYQALQKSNGVLPELFQCHGTADELVLHSWAEETNSMLKSLGVTTKFHSFPNVYHELSKTELDILKLWILTKLPGEMEKQK
uniprot
proteins
ec_number
3.1.2.22
uniprot
proteins
function
FUNCTION: Palmitoyl thioesterase that catalyzes depalmitoylation of CGAS and KCNMA1 (PubMed:22052940, PubMed:22399288, PubMed:37802025). Acts as a regulator of innate immunity by mediating depalmitoylation of CGAS, thereby preventing CGAS homodimerization and cyclic GMP-AMP synthase activity (PubMed:37802025). Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site (PubMed:22052940). {ECO:0000269|PubMed:22052940, ECO:0000269|PubMed:22399288, ECO:0000269|PubMed:37802025}.
uniprot
proteins
mass_dalton
26316
uniprot
proteins
mutagenesis
MUTAGEN 179; /note="D->A: Abolished palmitoyl thioesterase activity; when associated with A-211."; /evidence="ECO:0000269|PubMed:37802025"; MUTAGEN 211; /note="H->A: Abolished palmitoyl thioesterase activity; when associated with A-179."; /evidence="ECO:0000269|PubMed:37802025
uniprot
proteins
protein_family
AB hydrolase 2 family
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22052940
uniprot
proteins
pubmed
22399288
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
37802025
uniprot
proteins
sequence_length
237
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytosol {ECO:0000269|PubMed:22399288}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytosol {ECO:0000269|PubMed:22399288}.
uniprot
proteins