STK36
entrez
27148
canonical
uniprot
Q9NRP7
canonical
ensembl
ENSG00000163482
resolver
ensp
ENSP00000295709
resolver
ensp
ENSP00000375954
resolver
ensp
ENSP00000394095
resolver
ensp
ENSP00000595653
resolver
ensp
ENSP00000595656
resolver
genesymbol
STK36
resolver
genesymbol_syn
KIAA1278
resolver
hgnc
HGNC:17209
resolver
uniprot
A0A140VJW1
resolver
uniprot
B7WPM3
resolver
uniprot
Q8TC32
resolver
uniprot
Q9H9N9
resolver
uniprot
Q9UF35
resolver
uniprot
Q9ULE2
resolver
uniprot_entry
A0A140VJW1_HUMAN
resolver
uniprot_entry
STK36_HUMAN
resolver
uniprot_sec
B7WPM3
resolver
uniprot_sec
Q8TC32
resolver
uniprot_sec
Q9H9N9
resolver
uniprot_sec
Q9UF35
resolver
uniprot_sec
Q9ULE2
resolver
amino_acid_sequence
MEKYHVLEMIGEGSFGRVYKGRRKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLRHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYATSIFQLVSLILKDPVRWPSTISPCFKNFLQGLLTKDPRQRLSWPDLLYHPFIAGHVTIITEPAGPDLGTPFTSRLPPELQVLKDEQAHRLAPKGNQSRILTQAYKRMAEEAMQKKHQNTGPALEQEDKTSKVAPGTAPLPRLGATPQESSLLAGILASELKSSWAKSGTGEVPSAPRENRTTPDCERAFPEERPEVLGQRSTDVVDLENEEPDSDNEWQHLLETTEPVPIQLKAPLTLLCNPDFCQRIQSQLHEAGGQILKGILEGASHILPAFRVLSSLLSSCSDSVALYSFCREAGLPGLLLSLLRHSQESNSLQQQSWYGTFLQDLMAVIQAYFACTFNLERSQTSDSLQVFQEAANLFLDLLGKLLAQPDDSEQTLRRDSLMCFTVLCEAMDGNSRAISKAFYSSLLTTQQVVLDGLLHGLTVPQLPVHTPQGAPQVSQPLREQSEDIPGAISSALAAICTAPVGLPDCWDAKEQVCWHLANQLTEDSSQLRPSLISGLQHPILCLHLLKVLYSCCLVSEGLCRLLGQEPLALESLFMLIQGKVKVVDWEESTEVTLYFLSLLVFRLQNLPCGMEKLGSDVATLFTHSHVVSLVSAAACLLGQLGQQGVTFDLQPMEWMAAATHALSAPAEVRLTPPGSCGFYDGLLILLLQLLTEQGKASLIRDMSSSEMWTVLWHRFSMVLRLPEEASAQEGELSLSSPPSPEPDWTLISPQGMAALLSLAMATFTQEPQLCLSCLSQHGSILMSILKHLLCPSFLNQLRQAPHGSEFLPVVVLSVCQLLCFPFALDMDADLLIGVLADLRDSEVAAHLLQVCCYHLPLMQVELPISLLTRLALMDPTSLNQFVNTVSASPRTIVSFLSVALLSDQPLLTSDLLSLLAHTARVLSPSHLSFIQELLAGSDESYRPLRSLLGHPENSVRAHTYRLLGHLLQHSMALRGALQSQSGLLSLLLLGLGDKDPVVRCSASFAVGNAAYQAGPLGPALAAAVPSMTQLLGDPQAGIRRNVASALGNLGPEGLGEELLQCEVPQRLLEMACGDPQPNVKEAALIALRSLQQEPGIHQVLVSLGASEKLSLLSLGNQSLPHSSPRPASAKHCRKLIHLLRPAHSM
uniprot
proteins
disease_involvement
DISEASE: Ciliary dyskinesia, primary, 46 (CILD46) [MIM:619436]: A form of primary ciliary dyskinesia, a disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. CILD46 is an autosomal recessive form. No situs abnormalities have been observed. {ECO:0000269|PubMed:28543983}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine protein kinase which plays an important role in the smoothened pathway by regulating the activity of GLI transcription factors (PubMed:10806483, PubMed:28543983, PubMed:31279575, PubMed:38096226). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization (PubMed:10806483, PubMed:31279575, PubMed:38096226). Acts by mediating phosphorylation of GLI proteins, promoting their dissociation from SUFU (PubMed:28543983, PubMed:31279575, PubMed:38096226). Also catalyzes phosphorylation of ULK4 adapter (PubMed:38096226). GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur (PubMed:10806483). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function (PubMed:28543983). Essential for construction of the central pair apparatus of motile cilia (PubMed:28543983). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:28543983, ECO:0000269|PubMed:31279575, ECO:0000269|PubMed:38096226}.
uniprot
proteins
mass_dalton
143995
uniprot
proteins
mutagenesis
MUTAGEN 33; /note="K->R: Abolished protein kinase activity and ability to regulate smoothened pathway."; /evidence="ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:31279575, ECO:0000269|PubMed:38096226"; MUTAGEN 158..159; /note="TS->AA: Decreased ability to phosphorylate other proteins."; /evidence="ECO:0000269|PubMed:38096226"; MUTAGEN 158..159; /note="TS->EE: Mimics phosphorylation; increased ability to phosphorylate other proteins."; /evidence="ECO:0000269|PubMed:38096226
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated at Thr-158 and Ser-159, activating the protein kinase activity. {ECO:0000269|PubMed:38096226}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Ser/Thr protein kinase family
uniprot
proteins
pubmed
10574462
uniprot
proteins
pubmed
10806483
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
28543983
uniprot
proteins
pubmed
31279575
uniprot
proteins
pubmed
38096226
uniprot
proteins
sequence_length
1315
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:38096226}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:28543983}. Cytoplasm {ECO:0000269|PubMed:10806483}. Nucleus {ECO:0000269|PubMed:10806483}. Note=STK36 and ULK4 are mutually dependent for localization to ciliary tip (PubMed:38096226). Low levels also present in the nucleus (PubMed:10806483). {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:38096226}.
uniprot
proteins