Kcnk4
entrez
116489
canonical
uniprot
G3V8V5
canonical
ensembl
ENSRNOG00000021140
resolver
ensembl
ENSRNOG00055022782
resolver
ensembl
ENSRNOG00065029835
resolver
ensp
ENSRNOP00000028704
resolver
ensp
ENSRNOP00055031766
resolver
ensp
ENSRNOP00065042444
resolver
enst
ENSRNOT00000028704
resolver
enst
ENSRNOT00055039127
resolver
enst
ENSRNOT00065051545
resolver
genesymbol
Kcnk4
resolver
uniprot
Q924I4
resolver
uniprot_entry
KCNK4_RAT
resolver
uniprot_sec
Q924I4
resolver
activity_regulation
ACTIVITY REGULATION: Activated by various stimuli including intracellular basic pH, mechanical stretch and heat and polyunsaturated fatty acids such as arachidonic acid. {ECO:0000269|PubMed:11374070, ECO:0000269|PubMed:15677687}.
uniprot
proteins
amino_acid_sequence
MRSTTLLALLALVLLYLVSGALVFQALEQPHEQQVQKDLEDGRDQFLKDHPCVSQKNLEGFIKLVAEALGGGANPETSWTNSSNHSSAWNLGSAFFFSGTIITTIGYGNIALHTDAGRLFCIFYALVGIPLFGMLLAGVGDRLGSSLRRGIGHIEAVFLKWHVPPGLVRMLSAVLFLLIGCLLFVLTPTFVFSYMESWSKLEAIYFVIVTLTTVGFGDYVPGDGTGQNSPAYQPLVWFWILFGLAYFASVLTTIGNWLRAVSRRTRAEMGGLTAQAASWTGTVTARVTQRTGPSAPPPEKEQPLLPSSLPAPPAVAEPAHRPGSPAPAEKVETPPPTASALDYPSENLAFIDESSDTQSERGCALPRAPRGRRRPNPTKKPSRPRGPGRLRDKAVPV
uniprot
proteins
function
FUNCTION: K(+) channel that conducts voltage-dependent outward rectifying currents upon membrane depolarization. Voltage sensing is coupled to K(+) electrochemical gradient in an 'ion flux gating' mode where outward but not inward ion flow opens the gate. Converts to voltage-independent 'leak' conductance mode upon stimulation by various stimuli including mechanical membrane stretch, basic pH, heat and lipids (PubMed:11374070, PubMed:31630908). Homo- and heterodimerizes to form functional channels with distinct regulatory and gating properties (By similarity). At trigeminal A-beta afferent nerves, the heterodimer of KCNK2/TREK-1 and KCNK4/TRAAK is mostly coexpressed at nodes of Ranvier where it conducts voltage-independent mechanosensitive and thermosensitive currents, allowing rapid action potential repolarization, high speed and high frequence saltatory conduction on myelinated nerves to ensure prompt sensory responses (PubMed:31630908). Permeable to other monovalent cations such as Rb(+) and Cs(+) (By similarity). {ECO:0000250|UniProtKB:Q9NYG8, ECO:0000269|PubMed:11374070, ECO:0000269|PubMed:31630908}.
uniprot
proteins
mass_dalton
42920
uniprot
proteins
protein_family
Two pore domain potassium channel (TC 1.A.1.8) family
uniprot
proteins
pubmed
11374070
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15677687
uniprot
proteins
pubmed
31630908
uniprot
proteins
sequence_length
397
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11374070}; Multi-pass membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000269|PubMed:31630908}. Note=Localizes at the Ranvier nodes of myelinated afferent nerves. {ECO:0000269|PubMed:31630908}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical; Name=M1"; /evidence="ECO:0000250|UniProtKB:Q9NYG8"; TRANSMEM 119..151; /note="Helical; Name=M2"; /evidence="ECO:0000250|UniProtKB:Q9NYG8"; TRANSMEM 174..195; /note="Helical; Name=M3"; /evidence="ECO:0000250|UniProtKB:Q9NYG8"; TRANSMEM 235..261; /note="Helical; Name=M4"; /evidence="ECO:0000250|UniProtKB:Q9NYG8
uniprot
proteins