CASP10
entrez
843
canonical
uniprot
Q92851
canonical
ensembl
ENSG00000003400
resolver
ensp
ENSP00000237865
resolver
ensp
ENSP00000272879
resolver
ensp
ENSP00000286186
resolver
ensp
ENSP00000314599
resolver
ensp
ENSP00000363781
resolver
ensp
ENSP00000396835
resolver
ensp
ENSP00000512459
resolver
ensp
ENSP00000558532
resolver
genesymbol
CASP10
resolver
genesymbol_syn
MCH4
resolver
hgnc
HGNC:1500
resolver
uniprot
A0A0S2Z3G5
resolver
uniprot
A0A0S2Z3Z5
resolver
uniprot
Q68HC0
resolver
uniprot
Q6KF62
resolver
uniprot
Q6KF63
resolver
uniprot
Q8IUP5
resolver
uniprot
Q8WYQ8
resolver
uniprot
Q99845
resolver
uniprot
Q9Y2U6
resolver
uniprot
Q9Y2U7
resolver
uniprot_entry
A0A0S2Z3G5_HUMAN
resolver
uniprot_entry
A0A0S2Z3Z5_HUMAN
resolver
uniprot_entry
CASPA_HUMAN
resolver
uniprot_sec
Q68HC0
resolver
uniprot_sec
Q6KF62
resolver
uniprot_sec
Q6KF63
resolver
uniprot_sec
Q8IUP5
resolver
uniprot_sec
Q8WYQ8
resolver
uniprot_sec
Q99845
resolver
uniprot_sec
Q9Y2U6
resolver
uniprot_sec
Q9Y2U7
resolver
amino_acid_sequence
MKSQGQHWYSSSDKNCKVSFREKLLIIDSNLGVQDVENLKFLCIGLVPNKKLEKSSSASDVFEHLLAEDLLSEEDPFFLAELLYIIRQKKLLQHLNCTKEEVERLLPTRQRVSLFRNLLYELSEGIDSENLKDMIFLLKDSLPKTEMTSLSFLAFLEKQGKIDEDNLTCLEDLCKTVVPKLLRNIEKYKREKAIQIVTPPVDKEAESYQGEEELVSQTDVKTFLEALPQESWQNKHAGSNGNRATNGAPSLVSRGMQGASANTLNSETSTKRAAVYRMNRNHRGLCVIVNNHSFTSLKDRQGTHKDAEILSHVFQWLGFTVHIHNNVTKVEMEMVLQKQKCNPAHADGDCFVFCILTHGRFGAVYSSDEALIPIREIMSHFTALQCPRLAEKPKLFFIQACQGEEIQPSVSIEADALNPEQAPTSLQDSIPAEADFLLGLATVPGYVSFRHVEEGSWYIQSLCNHLKKLVPRMLKFLEKTMEIRGRKRTVWGAKQISATSLPTAISAQTPRPPMRRWSSVS
uniprot
proteins
disease_involvement
DISEASE: Autoimmune lymphoproliferative syndrome 2A (ALPS2A) [MIM:603909]: A disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia. {ECO:0000269|PubMed:10412980}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Familial non-Hodgkin lymphoma (NHL) [MIM:605027]: Cancer that starts in cells of the lymph system, which is part of the body's immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever and weight loss. {ECO:0000269|PubMed:12010812}. Note=The gene represented in this entry is involved in disease pathogenesis.; DISEASE: Gastric cancer (GASC) [MIM:613659]: A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease. {ECO:0000269|PubMed:11973654}. Note=The gene represented in this entry is involved in disease pathogenesis.
uniprot
proteins
ec_number
3.4.22.63
uniprot
proteins
function
FUNCTION: Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP8 and CASP9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. {ECO:0000269|PubMed:11717445, ECO:0000269|PubMed:16916640}.; FUNCTION: Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis. {ECO:0000269|PubMed:17822854}.; FUNCTION: Isoform C is proteolytically inactive. {ECO:0000269|PubMed:11717445}.
uniprot
proteins
mass_dalton
58951
uniprot
proteins
mutagenesis
MUTAGEN 401; /note="C->A: Abolishes proteolytic activity."; /evidence="ECO:0000269|PubMed:11717445
uniprot
proteins
post_translational_modification
PTM: Cleavage by granzyme B and autocatalytic activity generate the two active subunits.
uniprot
proteins
protein_family
Peptidase C14A family
uniprot
proteins
pubmed
10187817
uniprot
proteins
pubmed
10412980
uniprot
proteins
pubmed
11161814
uniprot
proteins
pubmed
11717445
uniprot
proteins
pubmed
11973654
uniprot
proteins
pubmed
12010812
uniprot
proteins
pubmed
14759258
uniprot
proteins
pubmed
15069192
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16446975
uniprot
proteins
pubmed
16916640
uniprot
proteins
pubmed
17822854
uniprot
proteins
pubmed
18563783
uniprot
proteins
pubmed
19557502
uniprot
proteins
pubmed
19900088
uniprot
proteins
pubmed
20025484
uniprot
proteins
pubmed
27378136
uniprot
proteins
pubmed
27535533
uniprot
proteins
pubmed
8755496
uniprot
proteins
pubmed
8962078
uniprot
proteins
pubmed
9045686
uniprot
proteins
sequence_length
521
uniprot
proteins