STOX1
entrez
219736
canonical
uniprot
Q6ZVD7
canonical
ensembl
ENSG00000165730
resolver
ensp
ENSP00000298596
resolver
ensp
ENSP00000382115
resolver
ensp
ENSP00000382118
resolver
ensp
ENSP00000382121
resolver
genesymbol
STOX1
resolver
genesymbol_syn
C10orf24
resolver
hgnc
HGNC:23508
resolver
uniprot
A2A3Q9
resolver
uniprot
A5D6Y7
resolver
uniprot
B0QZA4
resolver
uniprot
B0QZA5
resolver
uniprot
B0QZA6
resolver
uniprot
Q4F8Q6
resolver
uniprot
Q5I946
resolver
uniprot
Q5I947
resolver
uniprot
Q5I948
resolver
uniprot
Q5VX38
resolver
uniprot
Q5VX39
resolver
uniprot
Q6ZRY3
resolver
uniprot
Q96LR3
resolver
uniprot
Q96LS0
resolver
uniprot_entry
STOX1_HUMAN
resolver
uniprot_sec
A2A3Q9
resolver
uniprot_sec
A5D6Y7
resolver
uniprot_sec
B0QZA4
resolver
uniprot_sec
B0QZA5
resolver
uniprot_sec
B0QZA6
resolver
uniprot_sec
Q4F8Q6
resolver
uniprot_sec
Q5I946
resolver
uniprot_sec
Q5I947
resolver
uniprot_sec
Q5I948
resolver
uniprot_sec
Q5VX38
resolver
uniprot_sec
Q5VX39
resolver
uniprot_sec
Q6ZRY3
resolver
uniprot_sec
Q96LR3
resolver
uniprot_sec
Q96LS0
resolver
amino_acid_sequence
MARPVQLAPGSLALVLCRLEAQKAAGAAEEPGGRAVFRAFRRANARCFWNARLARAASRLAFQGWLRRGVLLVRAPPACLQVLRDAWRRRALRPPRGFRIRAVGDVFPVQMNPITQSQFVPLGEVLCCAISDMNTAQIVVTQESLLERLMKHYPGIAIPSEDILYTTLGTLIKERKIYHTGEGYFIVTPQTYFITNTTTQENKRMLPSDESRLMPASMTYLVSMESCAESAQENAAPISHCQSCQCFRDMHTQDVQEAPVAAEVTRKSHRGLGESVSWVQNGAVSVSAEHHICESTKPLPYTRDKEKGKKFGFSLLWRSLSRKEKPKTEHSSFSAQFPPEEWPVRDEDDLDNIPRDVEHEIIKRINPILTVDNLIKHTVLMQKYEEQKKYNSQGTSTDMLTIGHKYPSKEGVKKRQGLSAKPQGQGHSRRDRHKARNQGSEFQPGSIRLEKHPKLPATQPIPRIKSPNEMVGQKPLGEITTVLGSHLIYKKRISNPFQGLSHRGSTISKGHKIQKTSDLKPSQTGPKEKPFQKPRSLDSSRIFDGKAKEPYAEQPNDKMEAESIYINDPTVKPINDDFRGHLFSHPQQSMLQNDGKCCPFMESMLRYEVYGGENEVIPEVLRKSHSHFDKLGETKQTPHSLPSRGASFSDRTPSACRLVDNTIHQFQNLGLLDYPVGVNPLRQAARQDKDSEELLRKGFVQDAETTSLENEQLSNDDQALYQNEVEDDDGACSSLYLEEDDISENDDLRQMLPGHSQYSFTGGSQGNHLGKQKVIERSLTEYNSTMERVESQVLKRNECYKPTGLHATPGESQEPNLSAESCGLNSGAQFGFNYEEEPSVAKCVQASAPADERIFDYYSARKASFEAEVIQDTIGDTGKKPASWSQSPQNQEMRKHFPQKFQLFNTSHMPVLAQDVQYEHSHLEGTENHSMAGDSGIDSPRTQSLGSNNSVILDGLKRRQNFLQNVEGTKSSQPLTSNSLLPLTPVINV
uniprot
proteins
disease_involvement
DISEASE: Pre-eclampsia/eclampsia 4 (PEE4) [MIM:609404]: A hypertensive disorder of pregnancy characterized by new hypertension (blood pressure 140/90 or greater) presenting after 20 weeks' gestation with clinically relevant proteinuria. It impacts 2 individuals, the mother and her child, both of whom can be severely affected. Preeclampsia is one of the causes of maternal mortality and morbidity worldwide. {ECO:0000269|PubMed:15806103}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta (PubMed:24738702). Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway (By similarity). {ECO:0000250|UniProtKB:B2RQL2, ECO:0000269|PubMed:24738702}.; FUNCTION: [Isoform A]: Involved in cell cycle regulation by binding to the CCNB1 promoter, up-regulating its expression and promoting mitotic entry (PubMed:22253775). Induces phosphorylation of MAPT/tau (PubMed:22995177). {ECO:0000269|PubMed:22253775, ECO:0000269|PubMed:22995177}.
uniprot
proteins
mass_dalton
110962
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15806103
uniprot
proteins
pubmed
22253775
uniprot
proteins
pubmed
22995177
uniprot
proteins
pubmed
24738702
uniprot
proteins
pubmed
27535533
uniprot
proteins
sequence_length
989
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform A]: Cytoplasm {ECO:0000269|PubMed:22253775}. Nucleus {ECO:0000269|PubMed:22253775}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:22253775}. Note=In epithelial cells, diffusely expressed in the cytoplasm, particularly in peri-membrane cortical regions (By similarity). Concentrated at centrosomes during metaphase (PubMed:22253775). {ECO:0000250|UniProtKB:B2RQL2, ECO:0000269|PubMed:22253775}.; SUBCELLULAR LOCATION: [Isoform B]: Nucleus.; SUBCELLULAR LOCATION: [Isoform C]: Nucleus, nucleolus.
uniprot
proteins