Cd101
entrez
630146
canonical
uniprot
A8E0Y8
canonical
ensembl
ENSMUSG00000086564
resolver
ensp
ENSMUSP00000116643
resolver
enst
ENSMUST00000147399
resolver
genesymbol
Cd101
resolver
genesymbol_syn
Igsf2
resolver
uniprot
A8E0Y9
resolver
uniprot_entry
IGSF2_MOUSE
resolver
uniprot_sec
A8E0Y9
resolver
amino_acid_sequence
MACILCVASLFLSLTKFSIGQREVKIQEGPLYRAEGYPVSIRCTVSGHQGPSTQDFRWSIYLPSAPTKEVQIISTKDAGFSYAVYAQRVQSKEIYIERLQGDSVLLHISKLQMKDAGEYECHTPNTDGKYFGSYSAKTNLTVVPDTLSATMPSQTLSKKEGEPLELTCETTKATVQHTHLSLTWYLMQEGGGSQATEIVSLSKDFVLTPGSSYADRFVAGDVRLDKLGATSFRLSVGKLQPSDQGQVFCEATEWIQDPDETWTLITRKQTDQTALRIQPAARDFTVSITASSSPDEGKPLELVCLAVGRDGNPQLQGVWFLNGKEIAQTDAGGVLDLKRDYRDRASQGQLQVSKLSAQTFSLKIFSVGPEDVGTYSCEVAEVARTQMGSWQVLQRKQSPGYRVQLREPAARSVTVSAEQRTVWEGETLTLLCKAAGDVSALSVSWWLTPQDQSTPVFVAGMGQDGTVQLGVSSPGPAHRGNRRLEKVDWATFRLEIASAMVTDSGTYECRVSERLQNQAKGLQSTQKISVTVKSLKSSLRVNLMSRQPQVMLAHTFHLSCVVRANYSDLKLPFSVTWQFQPAGSGAFHRLIRIAHNGTVEWGDVLSQIHRKTKVSQSFFRSQLQIYDAAMEETGVYRCTVEVYDRDSICTSGPARVSATSNLLMITVTFPESKLSVNSSSQVQELSISSSTQIECAILSRSAGNLPLSIIWYFSSVSANASYLKILEMDQSSVVKYGDEFQTPRSKQKFYSEKVSQDLFLLNILSVEDSDQGHYHCAVEEWLLSTNDTWQKLERKTSGLTELKLRPTGSQVHVSKVNWTGNATEYGEAGFSCSLDGSGSTASLYSVTWYRGRGTATATAAAVANATATITAPAGSQMLVHLQYDGLLQYGREGSRRLQHCYRSSPTDFVLKLHRVEMEDAGIYWCRVTEWQQHGHPGKWINQASGESQRMVLRVLRSEPTVSSLICSSGPLLHFLIVCPFVMLLLLATSFLCLYRKARKLSQLSLSAKKEKALWVGMRKTSLQKEAGEESGHY
uniprot
proteins
function
FUNCTION: Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
114205
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250}.
uniprot
proteins
pubmed
12765969
uniprot
proteins
sequence_length
1033
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 971..991; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins