Guca1a
entrez
14913
canonical
uniprot
P43081
canonical
ensembl
ENSMUSG00000023982
resolver
ensp
ENSMUSP00000060027
resolver
enst
ENSMUST00000059348
resolver
genesymbol
Guca1a
resolver
genesymbol_syn
Gcap
resolver
genesymbol_syn
Gcap1
resolver
genesymbol_syn
Guca1
resolver
uniprot
Q8R0H3
resolver
uniprot_entry
GUC1A_MOUSE
resolver
uniprot_sec
Q8R0H3
resolver
amino_acid_sequence
MGNIMEGKSVEELSSTECHQWYKKFMTECPSGQLTLYEFRQFFGLKNLSPSASQYVEQMFETFDFNKDGYIDFMEYVAALSLVLKGKVEQKLRWYFKLYDVDGNGCIDRDELLTIIRAIRTINPWSDSSMSAEEFTDTVFAKIDINGDGELSLEEFMEGVQKDQMLLDTLTRSLDLTGIVRRLQNGEHEEAGTGDLAAEAAG
uniprot
proteins
function
FUNCTION: Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated (By similarity). This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure (By similarity). May be involved in cone photoreceptor light response and recovery of response in bright light (PubMed:25673692). {ECO:0000250|UniProtKB:P46065, ECO:0000269|PubMed:25673692}.
uniprot
proteins
mass_dalton
22986
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15961391
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
25673692
uniprot
proteins
pubmed
29435986
uniprot
proteins
pubmed
7983048
uniprot
proteins
pubmed
9620085
uniprot
proteins
sequence_length
202
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Lipid-anchor {ECO:0000250|UniProtKB:P46065}. Photoreceptor inner segment {ECO:0000269|PubMed:9620085}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:15961391, ECO:0000269|PubMed:9620085}. Note=Subcellular location is not affected by light or dark conditions.
uniprot
proteins