MINDY2
entrez
54629
canonical
uniprot
Q8NBR6
canonical
ensembl
ENSG00000128923
resolver
ensp
ENSP00000393231
resolver
ensp
ENSP00000452885
resolver
ensp
ENSP00000547399
resolver
ensp
ENSP00000547400
resolver
ensp
ENSP00000547402
resolver
ensp
ENSP00000547403
resolver
ensp
ENSP00000547406
resolver
ensp
ENSP00000603199
resolver
ensp
ENSP00000603200
resolver
ensp
ENSP00000633752
resolver
ensp
ENSP00000661501
resolver
genesymbol
MINDY2
resolver
genesymbol_syn
FAM63B
resolver
genesymbol_syn
KIAA1164
resolver
hgnc
HGNC:26954
resolver
uniprot
B2RTT8
resolver
uniprot
Q9ULQ6
resolver
uniprot_entry
MINY2_HUMAN
resolver
uniprot_sec
B2RTT8
resolver
uniprot_sec
Q9ULQ6
resolver
amino_acid_sequence
MESSPESLQPLEHGVAAGPASGTGSSQEGLQETRLAAGDGPGVWAAETSGGNGLGAAAARRSLPDSASPAGSPEVPGPCSSSAGLDLKDSGLESPAAAEAPLRGQYKVTASPETAVAGVGHELGTAGDAGARPDLAGTCQAELTAAGSEEPSSAGGLSSSCSDPSPPGESPSLDSLESFSNLHSFPSSCEFNSEEGAENRVPEEEEGAAVLPGAVPLCKEEEGEETAQVLAASKERFPGQSVYHIKWIQWKEENTPIITQNENGPCPLLAILNVLLLAWKVKLPPMMEIITAEQLMEYLGDYMLDAKPKEISEIQRLNYEQNMSDAMAILHKLQTGLDVNVRFTGVRVFEYTPECIVFDLLDIPLYHGWLVDPQIDDIVKAVGNCSYNQLVEKIISCKQSDNSELVSEGFVAEQFLNNTATQLTYHGLCELTSTVQEGELCVFFRNNHFSTMTKYKGQLYLLVTDQGFLTEEKVVWESLHNVDGDGNFCDSEFHLRPPSDPETVYKGQQDQIDQDYLMALSLQQEQQSQEINWEQIPEGISDLELAKKLQEEEDRRASQYYQEQEQAAAAAAAASTQAQQGQPAQASPSSGRQSGNSERKRKEPREKDKEKEKEKNSCVIL
uniprot
proteins
ec_number
3.4.19.12
uniprot
proteins
function
FUNCTION: Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins (PubMed:27292798). Binds to polyubiquitin chains of different linkage types, including 'Lys-6', 'Lys-11', 'Lys-29', 'Lys-33', 'Lys-48' and 'Lys-63' (PubMed:28082312). May play a regulatory role at the level of protein turnover (PubMed:27292798). {ECO:0000269|PubMed:27292798, ECO:0000269|PubMed:28082312}.
uniprot
proteins
mass_dalton
67106
uniprot
proteins
mutagenesis
MUTAGEN 519; /note="A->G: Strongly decreased binding to 'Lys-48' or 'Lys-63'-tetraubiquitin chains."; /evidence="ECO:0000269|PubMed:28082312"; MUTAGEN 546; /note="A->G: No effect on binding to 'Lys-48'- or 'Lys-63'-tetraubiquitin chains."; /evidence="ECO:0000269|PubMed:28082312
uniprot
proteins
protein_family
FAM63 subfamily
uniprot
proteins
protein_family
MINDY deubiquitinase family
uniprot
proteins
pubmed
10574461
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
27292798
uniprot
proteins
pubmed
28082312
uniprot
proteins
sequence_length
621
uniprot
proteins