JUND
entrez
3727
canonical
uniprot
P17535
canonical
ensembl
ENSG00000130522
resolver
ensp
ENSP00000252818
resolver
enst
ENST00000252818
resolver
genesymbol
JUND
resolver
hgnc
HGNC:6206
resolver
uniprot
Q53EK9
resolver
uniprot_entry
JUND_HUMAN
resolver
uniprot_sec
Q53EK9
resolver
amino_acid_sequence
METPFYGDEALSGLGGGASGSGGSFASPGRLFPGAPPTAAAGSMMKKDALTLSLSEQVAAALKPAAAPPPTPLRADGAPSAAPPDGLLASPDLGLLKLASPELERLIIQSNGLVTTTPTSSQFLYPKVAASEEQEFAEGFVKALEDLHKQNQLGAGAAAAAAAAAAGGPSGTATGSAPPGELAPAAAAPEAPVYANLSSYAGGAGGAGGAATVAFAAEPVPFPPPPPPGALGPPRLAALKDEPQTVPDVPSFGESPPLSPIDMDTQERIKAERKRLRNRIAASKCRKRKLERISRLEEKVKTLKSQNTELASTASLLREQVAQLKQKVLSHVNSGCQLLPQHQVPAY
uniprot
proteins
function
FUNCTION: Transcription factor binding AP-1 sites (PubMed:9989505). Heterodimerizes with proteins of the FOS family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to an AP-1 consensus sequence 3'-TGA[GC]TCA-5' and enhancing their transcriptional activity (PubMed:28981703, PubMed:9989505). {ECO:0000269|PubMed:28981703, ECO:0000269|PubMed:9989505}.
uniprot
proteins
mass_dalton
35174
uniprot
proteins
mutagenesis
MUTAGEN 30; /note="R->A: Reduced interaction with MEN1."; /evidence="ECO:0000269|PubMed:22327296"; MUTAGEN 31; /note="L->A: Reduced interaction with MEN1."; /evidence="ECO:0000269|PubMed:22327296"; MUTAGEN 32; /note="F->A: Loss of interaction with MEN1."; /evidence="ECO:0000269|PubMed:22327296"; MUTAGEN 33; /note="P->A: Loss of interaction with MEN1."; /evidence="ECO:0000269|PubMed:22327296"; MUTAGEN 34; /note="G->R: Loss of interaction with MEN1."; /evidence="ECO:0000269|PubMed:22327296"; MUTAGEN 35; /note="A->R: Reduced interaction with MEN1."; /evidence="ECO:0000269|PubMed:22327296"; MUTAGEN 36; /note="P->A: Reduced interaction with MEN1."; /evidence="ECO:0000269|PubMed:22327296"; MUTAGEN 37; /note="P->A: Reduced interaction with MEN1."; /evidence="ECO:0000269|PubMed:22327296"; MUTAGEN 46; /note="K->A: Loss of phosphorylation; when associated with A-47."; /evidence="ECO:0000269|PubMed:22327296"; MUTAGEN 46; /note="K->E: Reduced interaction with MEN1; when associated with E-47."; /evidence="ECO:0000269|PubMed:22327296"; MUTAGEN 47; /note="K->A: Loss of phosphorylation; when associated with A-46."; /evidence="ECO:0000269|PubMed:22327296"; MUTAGEN 47; /note="K->E: Reduced interaction with MEN1; when associated with E-46."; /evidence="ECO:0000269|PubMed:22327296"; MUTAGEN 52; /note="L->A: Loss of phosphorylation; when associated with A-54."; /evidence="ECO:0000269|PubMed:22327296"; MUTAGEN 54; /note="L->A: Loss of phosphorylation; when associated with A-52."; /evidence="ECO:0000269|PubMed:22327296
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MAP kinases MAPK8 and MAPK10; phosphorylation is inhibited in the presence of MEN1. {ECO:0000269|PubMed:22327296}.
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
protein_family
Jun subfamily
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
1903194
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
2112242
uniprot
proteins
pubmed
22327296
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28981703
uniprot
proteins
pubmed
9989505
uniprot
proteins
sequence_length
347
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins