MARCHF7
entrez
64844
canonical
uniprot
Q9H992
canonical
ensembl
ENSG00000136536
resolver
ensp
ENSP00000259050
resolver
ensp
ENSP00000386830
resolver
ensp
ENSP00000387238
resolver
ensp
ENSP00000442992
resolver
ensp
ENSP00000526629
resolver
ensp
ENSP00000526631
resolver
ensp
ENSP00000526632
resolver
ensp
ENSP00000526633
resolver
ensp
ENSP00000526634
resolver
ensp
ENSP00000526636
resolver
ensp
ENSP00000526638
resolver
ensp
ENSP00000526639
resolver
ensp
ENSP00000526640
resolver
ensp
ENSP00000526641
resolver
ensp
ENSP00000584895
resolver
ensp
ENSP00000584911
resolver
ensp
ENSP00000584913
resolver
ensp
ENSP00000584919
resolver
ensp
ENSP00000636761
resolver
ensp
ENSP00000636774
resolver
ensp
ENSP00000790551
resolver
ensp
ENSP00000795568
resolver
ensp
ENSP00000795571
resolver
enst
ENST00000539065
resolver
genesymbol
MARCHF7
resolver
genesymbol_syn
AXOT
resolver
genesymbol_syn
MARCH7
resolver
genesymbol_syn
RNF177
resolver
hgnc
HGNC:17393
resolver
uniprot
A8K9X1
resolver
uniprot
B7Z5K0
resolver
uniprot
B7Z7P5
resolver
uniprot
B7ZAR7
resolver
uniprot
D3DPB0
resolver
uniprot
F5H6W4
resolver
uniprot
Q53GQ1
resolver
uniprot
Q9BTR9
resolver
uniprot_entry
B7Z5K0_HUMAN
resolver
uniprot_entry
B7ZAR7_HUMAN
resolver
uniprot_entry
F5H6W4_HUMAN
resolver
uniprot_entry
MARH7_HUMAN
resolver
uniprot_sec
A8K9X1
resolver
uniprot_sec
B7Z7P5
resolver
uniprot_sec
D3DPB0
resolver
uniprot_sec
Q53GQ1
resolver
uniprot_sec
Q9BTR9
resolver
amino_acid_sequence
MESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASASASPFQSAWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSDSSWRHSQVPRSSSMVLGSFGTDLMRERRDLERRTDSSISNLMDYSHRSGDFTTSSYVQDRVPSYSQGARPKENSMSTLQLNTSSTNHQLPSEHQTILSSRDSRNSLRSNFSSRESESSRSNTQPGFSYSSSRDEAPIISNSERVVSSQRPFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSSQDSLNTRSLNSENSYVSPRILTASQSRSNVPSASEVPDNRASEASQGFRFLRRRWGLSSLSHNHSSESDSENFNQESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRIPTSDTSSRSHIFRRESNEVVHLEAQNDPLGAAANRPQASAASSSATTGGSTSDSAQGGRNTGISGILPGSLFRFAVPPALGSNLTDNVMITVDIIPSGWNSADGKSDKTKSAPSRDPERLQKIKESLLLEDSEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLEAVTTCELCKEKLELNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGNTNEPSTRVRFINLARTLQAHMEDLETSEDDSEEDGDHNRTFDIA
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:16868077). May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis (PubMed:31270356). Promotes 'Lys-6', 'Lys-11' and 'Lys-63'-linked mixed polyubiquitination on ATG14 leading to the inhibition of autophagy by impairing the interaction between ATG14 and STX7 (PubMed:37632749). Participates in the dopamine-mediated negative regulation of the NLRP3 inflammasome by promoting its ubiquitination and subsequent degradation (PubMed:25594175). {ECO:0000250|UniProtKB:Q9WV66, ECO:0000269|PubMed:16868077, ECO:0000269|PubMed:25594175, ECO:0000269|PubMed:31270356, ECO:0000269|PubMed:37632749}.
uniprot
proteins
mass_dalton
78051
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15670816
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16868077
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25594175
uniprot
proteins
pubmed
31270356
uniprot
proteins
pubmed
37632749
uniprot
proteins
sequence_length
704
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:37632749}.
uniprot
proteins