Dcun1d5
entrez
76863
canonical
uniprot
Q9CXV9
canonical
ensembl
ENSMUSG00000032002
resolver
ensp
ENSMUSP00000034499
resolver
ensp
ENSMUSP00000150564
resolver
ensp
ENSMUSP00000309199
resolver
ensp
ENSMUSP00000309201
resolver
enst
ENSMUST00000034499
resolver
enst
ENSMUST00000215683
resolver
genesymbol
Dcun1d5
resolver
genesymbol_syn
SCCRO5
resolver
uniprot
A0A1N9M8A6
resolver
uniprot
Q5XKI2
resolver
uniprot
Q9CUS4
resolver
uniprot_entry
A0A1N9M8A6_MOUSE
resolver
uniprot_entry
DCNL5_MOUSE
resolver
uniprot_sec
Q5XKI2
resolver
uniprot_sec
Q9CUS4
resolver
amino_acid_sequence
MPVKKKRKAPGVAAAVAEDAGLKKCKIPSYCRSQPPARLISGEEDFSRKKCLAWFYEYAGPDEVVGPEGMEKFCEDIGVEPENIIMLVLAWKLEAESMGFFTKEEWLKGMTSLQCDCTEKLQSRFDFLRSQLNDISSFKNIYRYAFDFARDKDQRSLDIDTAKSMLALLLGRTWPLFSVFYQYLEQSKYRVMNKDQWYNVLEFSRTVHADLSNYDEDGAWPVLLDEFVEWQKIRQTS
uniprot
proteins
function
FUNCTION: Contributes to the neddylation of all cullins by transferring NEDD8 from N-terminally acetylated NEDD8-conjugating E2s enzyme to different cullin C-terminal domain-RBX complexes which is necessary for the activation of cullin-RING E3 ubiquitin ligases (CRLs) (PubMed:26792857). May play a role in DNA damage response and may participate in cell proliferation and anchorage-independent cell growth (By similarity). {ECO:0000250|UniProtKB:Q9BTE7, ECO:0000269|PubMed:26792857}.
uniprot
proteins
mass_dalton
27579
uniprot
proteins
mutagenesis
MUTAGEN 41; /note="S->A: Abolishes phosphorylation."; /evidence="ECO:0000269|PubMed:29958295"; MUTAGEN 195; /note="D->A: Does not affect phosphorylarion at Ser-41; when associated with R-219."; /evidence="ECO:0000269|PubMed:29958295"; MUTAGEN 219; /note="A->R: Does not affect phosphorylarion at Ser-41; when associated with A-195."; /evidence="ECO:0000269|PubMed:29958295
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-41 is independent of cullin's interaction (PubMed:29958295). Phosphorylated in response to both TICAM1 and MYD88 dependent Toll-like receptor (TLR) pathway activation (PubMed:29958295). Phosphorylated in response to IL1B stimulation (By similarity). {ECO:0000250|UniProtKB:Q9BTE7, ECO:0000269|PubMed:29958295}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26792857
uniprot
proteins
pubmed
26906416
uniprot
proteins
pubmed
29958295
uniprot
proteins
sequence_length
237
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29958295}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9BTE7}. Note=Subcellular localization is independent of the interaction with cullins. {ECO:0000250|UniProtKB:Q9BTE7}.
uniprot
proteins