CCL14
entrez
6358
canonical
uniprot
Q16627
canonical
ensembl
ENSG00000276409
resolver
ensembl
ENSG00000277236
resolver
ensp
ENSP00000479097
resolver
ensp
ENSP00000481023
resolver
genesymbol
CCL14
resolver
genesymbol_syn
NCC2
resolver
genesymbol_syn
SCYA14
resolver
hgnc
HGNC:10612
resolver
uniprot
E1P649
resolver
uniprot
E1P650
resolver
uniprot
Q13954
resolver
uniprot_entry
CCL14_HUMAN
resolver
uniprot_sec
E1P649
resolver
uniprot_sec
E1P650
resolver
uniprot_sec
Q13954
resolver
amino_acid_sequence
MKISVAAIPFFLLITIALGTKTESSSRGPYHPSECCFTYTTYKIPRQRIMDYYETNSQCSKPGIVFITKRGHSVCTNPSDKWVQDYIKDMKEN
uniprot
proteins
function
FUNCTION: Has weak activities on human monocytes and acts via receptors that also recognize MIP-1 alpha. It induces intracellular Ca(2+) changes and enzyme release, but no chemotaxis, at concentrations of 100-1,000 nM, and is inactive on T-lymphocytes, neutrophils, and eosinophil leukocytes. Enhances the proliferation of CD34 myeloid progenitor cells. The processed form HCC-1(9-74) is a chemotactic factor that attracts monocytes, eosinophils, and T-cells and is a ligand for CCR1, CCR3 and CCR5. {ECO:0000269|PubMed:11085751}.
uniprot
proteins
mass_dalton
10678
uniprot
proteins
post_translational_modification
PTM: The N-terminal processed forms HCC-1(3-74), HCC-1(4-74) and HCC-1(9-74) are produced in small amounts by proteolytic cleavage after secretion in blood.; PTM: HCC-1(1-74), but not HCC-1(3-74) and HCC-1(4-74), is partially O-glycosylated; the O-linked glycan consists of one Gal-GalNAc disaccharide, further modified by two N-acetylneuraminic acids. {ECO:0000269|PubMed:10978165}.
uniprot
proteins
protein_family
Intercrine beta (chemokine CC) family
uniprot
proteins
pubmed
10213461
uniprot
proteins
pubmed
10978165
uniprot
proteins
pubmed
11085751
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17691823
uniprot
proteins
pubmed
8551235
uniprot
proteins
pubmed
9600961
uniprot
proteins
sequence_length
93
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins