CTDNEP1
entrez
23399
canonical
uniprot
O95476
canonical
ensembl
ENSG00000175826
resolver
ensp
ENSP00000321732
resolver
ensp
ENSP00000458758
resolver
ensp
ENSP00000460683
resolver
ensp
ENSP00000461749
resolver
ensp
ENSP00000634676
resolver
ensp
ENSP00000634677
resolver
enst
ENST00000318988
resolver
enst
ENST00000573600
resolver
enst
ENST00000574205
resolver
enst
ENST00000574322
resolver
enst
ENST00000964617
resolver
enst
ENST00000964618
resolver
genesymbol
CTDNEP1
resolver
genesymbol_syn
DULLARD
resolver
hgnc
HGNC:19085
resolver
uniprot
D3DTN7
resolver
uniprot
Q96GQ9
resolver
uniprot_entry
CNEP1_HUMAN
resolver
uniprot_sec
D3DTN7
resolver
uniprot_sec
Q96GQ9
resolver
amino_acid_sequence
MMRTQCLLGLRTFVAFAAKLWSFFIYLLRRQIRTVIQYQTVRYDILPLSPVSRNRLAQVKRKILVLDLDETLIHSHHDGVLRPTVRPGTPPDFILKVVIDKHPVRFFVHKRPHVDFFLEVVSQWYELVVFTASMEIYGSAVADKLDNSRSILKRRYYRQHCTLELGSYIKDLSVVHSDLSSIVILDNSPGAYRSHPDNAIPIKSWFSDPSDTALLNLLPMLDALRFTADVRSVLSRNLHQHRLW
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Serine/threonine protein phosphatase forming with CNEP1R1 an active phosphatase complex that dephosphorylates and may activate LPIN1 and LPIN2. LPIN1 and LPIN2 are phosphatidate phosphatases that catalyze the conversion of phosphatidic acid to diacylglycerol and control the metabolism of fatty acids at different levels. May indirectly modulate the lipid composition of nuclear and/or endoplasmic reticulum membranes and be required for proper nuclear membrane morphology and/or dynamics. May also indirectly regulate the production of lipid droplets and triacylglycerol. May antagonize BMP signaling. {ECO:0000269|PubMed:17420445, ECO:0000269|PubMed:22134922}.
uniprot
proteins
mass_dalton
28377
uniprot
proteins
mutagenesis
MUTAGEN 67; /note="D->N,E: Abolishes phosphatase activity."; /evidence="ECO:0000269|PubMed:17420445
uniprot
proteins
protein_family
Dullard family
uniprot
proteins
pubmed
12083771
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16533400
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17420445
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
22134922
uniprot
proteins
pubmed
25944354
uniprot
proteins
sequence_length
244
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 7..29; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins