Shoc2
entrez
309548
canonical
uniprot
Q6AYI5
canonical
ensembl
ENSRNOG00000015339
resolver
ensembl
ENSRNOG00065010889
resolver
ensp
ENSRNOP00000020580
resolver
ensp
ENSRNOP00065013562
resolver
enst
ENSRNOT00000020580
resolver
enst
ENSRNOT00065017666
resolver
genesymbol
Shoc2
resolver
uniprot_entry
SHOC2_RAT
resolver
amino_acid_sequence
MSSSLGKEKDSKEKDPKVPSAKEREKEAKASGGFGKESKEKEPKTKGKDAKDGKKESSAAQPGVAFSVDNTIKRPNPALGTRKKSSNAEVTKELNKCREENSMRLDLSKRSIHILPPSVKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITAVEKDVRNLPRLSTLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNLSSLNRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQIVAGGPSFIIQFLKMQGPYRAMV
uniprot
proteins
function
FUNCTION: Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates activation of the MAPK pathway (By similarity). Acts as a scaffolding protein in the SMP complex (By similarity). The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities (By similarity). The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (By similarity). Acts as an inhibitor of keratinocyte differentiation via interaction with RAS protein complexes that promote ERK activation (By similarity). {ECO:0000250|UniProtKB:Q9UQ13}.
uniprot
proteins
mass_dalton
64921
uniprot
proteins
protein_family
SHOC2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
582
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9UQ13}. Nucleus {ECO:0000250|UniProtKB:Q9UQ13}. Note=Translocates from cytoplasm to nucleus upon growth factor stimulation. {ECO:0000250|UniProtKB:Q9UQ13}.
uniprot
proteins