TMEM81
entrez
388730
canonical
uniprot
Q6P7N7
canonical
ensembl
ENSG00000174529
resolver
ensp
ENSP00000356135
resolver
enst
ENST00000367167
resolver
genesymbol
TMEM81
resolver
hgnc
HGNC:32349
resolver
uniprot
Q6UVZ4
resolver
uniprot_entry
TMM81_HUMAN
resolver
uniprot_sec
Q6UVZ4
resolver
amino_acid_sequence
MKVLATSFVLGSLGLAFYLPLVVTTPKTLAIPEKLQEAVGKVIINATTCTVTCGLGYKEETVCEVGPDGVRRKCQTRRLECLTNWICGMLHFTILIGKEFELSCLSSDILEFGQEAFRFTWRLARGVISTDDEVFKPFQANSHFVKFKYAQEYDSGTYRCDVQLVKNLRLVKRLYFGLRVLPPNLVNLNFHQSLTEDQKLIDEGLEVNLDSYSKPHHPKWKKKVASALGIGIAIGVVGGVLVRIVLCALRGGLQQ
uniprot
proteins
function
FUNCTION: Essential fertilization factor required for male fertility. Part of a conserved trimeric sperm complex with the essential fertilization factors IZUMO1 and SPACA6 which bridges sperm and oocyte membranes during fertilization by binding to IZUMO1R/JUNO on the oocyte. {ECO:0000269|PubMed:39423812}.
uniprot
proteins
mass_dalton
28468
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
39423812
uniprot
proteins
sequence_length
255
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:B8JI67}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 227..247; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins