Nagk
entrez
297393
canonical
uniprot
P81799
canonical
ensembl
ENSRNOG00000013911
resolver
ensembl
ENSRNOG00055012149
resolver
ensembl
ENSRNOG00060003115
resolver
ensembl
ENSRNOG00065016128
resolver
ensp
ENSRNOP00000084218
resolver
ensp
ENSRNOP00000093402
resolver
ensp
ENSRNOP00055016636
resolver
ensp
ENSRNOP00060003786
resolver
ensp
ENSRNOP00065021083
resolver
enst
ENSRNOT00000108444
resolver
enst
ENSRNOT00000118649
resolver
enst
ENSRNOT00055020645
resolver
enst
ENSRNOT00060005148
resolver
enst
ENSRNOT00065026839
resolver
genesymbol
Nagk
resolver
uniprot
A0A8I6AJS1
resolver
uniprot
Q32Q91
resolver
uniprot_entry
A0A8I6AJS1_RAT
resolver
uniprot_entry
NAGK_RAT
resolver
uniprot_sec
Q32Q91
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by the cysteine modifiers iodoacetamide, N-ethylmaleimide and 5,5'-dithiobis(2-nitrobenzoic acid). {ECO:0000269|PubMed:9523722}.
uniprot
proteins
amino_acid_sequence
MAALYGGVEGGGTRSKVLLLSEDGQILAEADGLSTNHWLIGTGTCVERINEMVDRAKRKAGVDPLVPLRSLGLSLSGGEQEDAVRLLMEELRDRFPYLSESYFITTDAAGSIATATPDGGIVLISGTGSNCRLINPDGSESGCGGWGHMMGDEGSAYWIAHQAVKIVFDSIDNLEAAPHDIGHVKQAMFNYFQVPDRLGILTHLYRDFDKSKFAGFCQKIAEGAQQGDPLSRFIFRKAGEMLGRHVVAVLPEIDPVLFQGELGLPILCVGSVWKSWELLKEGFLLALTQGREQQAQNSFSSFTLMKLRHSSALGGASLGARHIGHHLPMDYSVNAIAFYSYTF
uniprot
proteins
ec_number
2.7.1.-
uniprot
proteins
ec_number
2.7.1.59
uniprot
proteins
ec_number
2.7.1.60
uniprot
proteins
function
FUNCTION: Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate (PubMed:9523722). Also has N-acetylmannosamine (ManNAc) kinase activity (By similarity). Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway (By similarity). Also involved in innate immunity by promoting detection of bacterial peptidoglycan by NOD2: acts by catalyzing phosphorylation of muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, to generate 6-O-phospho-muramyl dipeptide, which acts as a direct ligand for NOD2 (By similarity). {ECO:0000250|UniProtKB:Q9QZ08, ECO:0000250|UniProtKB:Q9UJ70, ECO:0000269|PubMed:9523722}.
uniprot
proteins
mass_dalton
37196
uniprot
proteins
pathway_participation
PATHWAY: Amino-sugar metabolism; N-acetylneuraminate degradation. {ECO:0000250|UniProtKB:Q9QZ08}.
uniprot
proteins
protein_family
Eukaryotic-type N-acetylglucosamine kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9523722
uniprot
proteins
sequence_length
343
uniprot
proteins