Rabggta
entrez
56187
canonical
uniprot
Q9JHK4
canonical
ensembl
ENSMUSG00000040472
resolver
ensp
ENSMUSP00000128668
resolver
ensp
ENSMUSP00000133032
resolver
ensp
ENSMUSP00000154725
resolver
genesymbol
Rabggta
resolver
uniprot
Q9JLX2
resolver
uniprot_entry
PGTA_MOUSE
resolver
uniprot_sec
Q9JLX2
resolver
activity_regulation
ACTIVITY REGULATION: The enzymatic reaction requires the aid of a Rab escort protein (also called component A), such as CHM. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKREAGELDESVLELTSQILGANPDFATLWNCRREVLQQLETQKSPEELAALVKAELGFLESCLRVNPKSYGTWHHRCWLLSRLPEPNWARELELCARFLEADERNFHCWDYRRFVAAQAAVAPAEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPENVLLRELELVQNAFFTDPNDQSAWFYHRWLLGRAEPHDVLCCLHVSREEACLSVCFSRPLIVGSKMGTLLLTVDEAPLSVEWRTPDGRNRPSHVWLCDLPAASLNDHLPQHTFRVIWTGSDTQKECVLLKGHQECWCRDSATDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLMRALDPLLYEKETLEYFSTLKAVDPMRAAYLDDLRSKFLVENSVLKMEYADVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRALPPALAALRCLEVLQASDNVLENLDGVANLPRLRELLLCNNRLQQSAALQTLASCPRLVFLNLQGNSLCQEEGIRERLAEMLPSVSSILT
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Rabggta are the cause of the gunmetal (gm) phenotype. Mice homozygous for gm have prolonged bleeding, thrombocytopenia and reduced platelet alpha- and delta-granule contents. {ECO:0000269|PubMed:10737774}.
uniprot
proteins
ec_number
2.5.1.60
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. {ECO:0000269|PubMed:10737774}.
uniprot
proteins
mass_dalton
64989
uniprot
proteins
protein_family
Protein prenyltransferase subunit alpha family
uniprot
proteins
pubmed
10737774
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
567
uniprot
proteins