Ptbp1
entrez
19205
canonical
uniprot
P17225
canonical
ensembl
ENSMUSG00000006498
resolver
ensp
ENSMUSP00000093109
resolver
ensp
ENSMUSP00000126192
resolver
ensp
ENSMUSP00000127783
resolver
ensp
ENSMUSP00000308044
resolver
enst
ENSMUST00000095457
resolver
genesymbol
Ptbp1
resolver
genesymbol_syn
Ptb
resolver
uniprot
F6QFN2
resolver
uniprot
Q8BGJ5
resolver
uniprot
Q8CB58
resolver
uniprot
Q922I7
resolver
uniprot_entry
F6QFN2_MOUSE
resolver
uniprot_entry
PTBP1_MOUSE
resolver
uniprot_entry
Q8CB58_MOUSE
resolver
uniprot_sec
Q8BGJ5
resolver
uniprot_sec
Q922I7
resolver
amino_acid_sequence
MDGIVPDIAVGTKRGSDELFSTCVSNGPFIMSSSASAANGNDSKKFKGDNRSAGVPSRVIHVRKLPSDVTEGEVISLGLPFGKVTNLLMLKGKNQAFIEMNTEEAANTMVNYYTSVAPVLRGQPIYIQFSNHKELKTDSSPNQARAQAALQAVNSVQSGNLALAASAAAVDAGMAMAGQSPVLRIIVENLFYPVTLDVLHQIFSKFGTVLKIITFTKNNQFQALLQYADPVSAQHAKLSLDGQNIYNACCTLRIDFSKLTSLNVKYNNDKSRDYTRPDLPSGDSQPSLDQTMAAAFGAPGIMSASPYAGAGFPPTFAIPQAAGLSVPNVHGALAPLAIPSAAAAAAASRIAIPGLAGAGNSVLLVSNLNPERVTPQSLFILFGVYGDVQRVKILFNKKENALVQMADGSQAQLAMSHLNGHKLHGKSVRITLSKHQSVQLPREGQEDQGLTKDYGSSPLHRFKKPGSKNFQNIFPPSATLHLSNIPPSVSEDDLKSLFSSNGGVVKGFKFFQKDRKMALIQMGSVEEAVQALIELHNHDLGENHHLRVSFSKSTI
uniprot
proteins
function
FUNCTION: Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. Binds to polypyrimidine-rich controlling element (PCE) of CFTR and promotes exon skipping of CFTR exon 9, thereby antagonizing TIA1 and its role in exon inclusion of CFTR exon 9. Plays a role in the splicing of pyruvate kinase PKM by binding repressively to a polypyrimidine tract flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform. {ECO:0000250|UniProtKB:P26599}.
uniprot
proteins
mass_dalton
59322
uniprot
proteins
pubmed
11724819
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1722210
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21518792
uniprot
proteins
sequence_length
555
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P26599}. Cytoplasm {ECO:0000250|UniProtKB:P26599}. Cytoplasm, P-body {ECO:0000250|UniProtKB:P26599}.
uniprot
proteins