Bag5
entrez
366734
canonical
uniprot
Q5QJC9
canonical
ensembl
ENSRNOG00000058841
resolver
ensembl
ENSRNOG00055029976
resolver
ensembl
ENSRNOG00060028250
resolver
ensembl
ENSRNOG00065026030
resolver
ensp
ENSRNOP00000071757
resolver
ensp
ENSRNOP00000099193
resolver
ensp
ENSRNOP00000100157
resolver
ensp
ENSRNOP00000103369
resolver
ensp
ENSRNOP00000103920
resolver
ensp
ENSRNOP00055042894
resolver
ensp
ENSRNOP00060040968
resolver
ensp
ENSRNOP00065036748
resolver
enst
ENSRNOT00000085594
resolver
enst
ENSRNOT00000121681
resolver
enst
ENSRNOT00000132655
resolver
enst
ENSRNOT00000143099
resolver
enst
ENSRNOT00000152440
resolver
enst
ENSRNOT00055051957
resolver
enst
ENSRNOT00060049085
resolver
enst
ENSRNOT00065044857
resolver
genesymbol
Bag5
resolver
uniprot_entry
BAG5_RAT
resolver
amino_acid_sequence
MDMGNQHPSISRLQEIQREVKSIEQQVVGFSGLSDDKNYKRLERILTKQLFEIDSVDTEGKGDIQQARKRAAQDTERLLKELEQNANHPHRIEIKNIFQEAQALVKEKTVPFYSGSNCVTSEFEEAIQDIILRLTHVKTGGKISLRKARYHTLTKICAVQEIIEDCVRKQPSLPLSEDVHPSVAKINSVMCEVNKARGTLIALLMGVDSSETCRHLSCVLSGLMADLDALDVCGRTEIRNYRREVVEDINKLLKYLDLEEEADNTHAFDLGQNHSIIKIENVLKRMREMKNELLQAQSPPELYLRSKTELQGLIGQLDEVSLEKNPCIREARRRAVIEVQTLITYLDLKEALEKRKLFPCEETPPHKAVWNVLGNLSEIQGEVLSFGGNRTDKNYIRLEELLTKQLLTLDAVDPLGEEKCKAARKQAVKLAQNILSYLDMKSDEWEY
uniprot
proteins
function
FUNCTION: Co-chaperone for HSP/HSP70 proteins. It functions as a nucleotide-exchange factor promoting the release of ADP from HSP70, thereby activating HSP70-mediated protein refolding (By similarity). Has an essential role in maintaining proteostasis at junctional membrane complexes (JMC), where it may function as a scaffold between the HSPA8 chaperone and JMC proteins enabling correct, HSPA8-dependent JMC protein folding (By similarity). Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (PubMed:15603737). {ECO:0000250|UniProtKB:Q9UL15, ECO:0000269|PubMed:15603737}.
uniprot
proteins
mass_dalton
51030
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15603737
uniprot
proteins
sequence_length
447
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Note=In cardiomyocytes, localized at specialized membrane contact sites between T-tubules and the sarcoplasmic reticulum, known as junctional membrane complexes. {ECO:0000250|UniProtKB:Q8CI32}.
uniprot
proteins