Ren1
entrez
24715
canonical
uniprot
P08424
canonical
ensembl
ENSRNOG00000002937
resolver
ensembl
ENSRNOG00055021334
resolver
ensembl
ENSRNOG00060016874
resolver
ensembl
ENSRNOG00065020497
resolver
ensp
ENSRNOP00000003951
resolver
ensp
ENSRNOP00055029659
resolver
ensp
ENSRNOP00060023284
resolver
ensp
ENSRNOP00065027808
resolver
enst
ENSRNOT00000003951
resolver
enst
ENSRNOT00055036484
resolver
enst
ENSRNOT00060028921
resolver
enst
ENSRNOT00065034664
resolver
genesymbol
Ren1
resolver
genesymbol_syn
Ren
resolver
uniprot
Q63497
resolver
uniprot_entry
RENI_RAT
resolver
uniprot_sec
Q63497
resolver
activity_regulation
ACTIVITY REGULATION: Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing. {ECO:0000250|UniProtKB:P00797}.
uniprot
proteins
amino_acid_sequence
MGGRRMPLWALLLLWTSCSFSLPTDTASFGRILLKKMPSVREILEERGVDMTRISAEWGEFIKKSSFTNVTSPVVLTNYLDTQYYGEIGIGTPSQTFKVIFDTGSANLWVPSTKCGPLYTACEIHNLYDSSESSSYMENGTEFTIHYGSGKVKGFLSQDVVTVGGIIVTQTFGEVTELPLIPFMLAKFDGVLGMGFPAQAVDGVIPVFDHILSQRVLKEEVFSVYYSRESHLLGGEVVLGGSDPQHYQGNFHYVSISKAGSWQITMKGVSVGPATLLCEEGCMAVVDTGTSYISGPTSSLQLIMQALGVKEKRANNYVVNCSQVPTLPDISFYLGGRTYTLSNMDYVQKNPFRNDDLCILALQGLDIPPPTGPVWVLGATFIRKFYTEFDRHNNRIGFALAR
uniprot
proteins
ec_number
3.4.23.15
uniprot
proteins
function
FUNCTION: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. {ECO:0000250|UniProtKB:P00797}.
uniprot
proteins
mass_dalton
44276
uniprot
proteins
protein_family
Peptidase A1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
3039496
uniprot
proteins
pubmed
3047403
uniprot
proteins
pubmed
3287330
uniprot
proteins
pubmed
8490598
uniprot
proteins
sequence_length
402
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P00797}. Membrane {ECO:0000250|UniProtKB:P00797}. Note=Associated to membranes via binding to ATP6AP2. {ECO:0000250|UniProtKB:P00797}.
uniprot
proteins