Cyba
entrez
79129
canonical
uniprot
Q62737
canonical
ensembl
ENSRNOG00000013014
resolver
ensp
ENSRNOP00000017564
resolver
enst
ENSRNOT00000017564
resolver
genesymbol
Cyba
resolver
uniprot
Q9ER27
resolver
uniprot_entry
CY24A_RAT
resolver
uniprot_sec
Q9ER27
resolver
amino_acid_sequence
MGQIEWAMWANEQALASGLILITGGIVATAGRFTQWYFGAYSIVAGVLICLLEYPRGKRKKGSTMERCGQKYLTAVVKLFGPLTRNYYVRAVLHLLLSVPAGFLLATILGTVCLAIASVIYLLAAIRGEQWTPIEPKPKERPQVGGTIKQPPTNPPPRPPAEVRKKPSEAEEEAASAGGPQVNPIPVTDEVV
uniprot
proteins
function
FUNCTION: Subunit of NADPH oxidase complexes that is required for the NADPH oxidase activity that generates, in various cell types, superoxide from molecular oxygen utilizing NADPH as an electron donor (PubMed:15322091). Subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). In the activated complex, electrons are first transferred from NADPH to flavin adenine dinucleotide (FAD) and subsequently transferred via two heme molecules to molecular oxygen, producing superoxide through an outer-sphere reaction. Activation of the NADPH oxidase complex is initiated by the assembly of cytosolic subunits of the NADPH oxidase complex with the core NADPH oxidase complex to form a complex at the plasma membrane or phagosomal membrane. This activation process is initiated by phosphorylation dependent binding of the cytosolic NCF1/p47-phox subunit to the C-terminus of CYBA/p22-phox. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide (By similarity). {ECO:0000250|UniProtKB:P13498, ECO:0000269|PubMed:15322091}.
uniprot
proteins
mass_dalton
20750
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-147 enhances NADPH oxidase activity by promoting NCF1/p47-phox binding. {ECO:0000250|UniProtKB:P13498}.; PTM: Ubiquitinated at Lys-149 likely by RNF145. {ECO:0000250|UniProtKB:Q61462}.
uniprot
proteins
protein_family
P22phox family
uniprot
proteins
pubmed
10938010
uniprot
proteins
pubmed
15322091
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7578211
uniprot
proteins
sequence_length
192
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P13498}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P13498}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..30; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P13498"; TRANSMEM 36..53; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P13498"; TRANSMEM 87..104; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P13498"; TRANSMEM 106..126; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P13498
uniprot
proteins