SLC2A4
entrez
6517
canonical
uniprot
P14672
canonical
ensembl
ENSG00000181856
resolver
ensembl
ENSG00000288174
resolver
ensp
ENSP00000320935
resolver
genesymbol
SLC2A4
resolver
genesymbol_syn
GLUT4
resolver
hgnc
HGNC:11009
resolver
uniprot
Q05BQ3
resolver
uniprot
Q14CX2
resolver
uniprot_entry
GLUT4_HUMAN
resolver
uniprot_sec
Q05BQ3
resolver
uniprot_sec
Q14CX2
resolver
amino_acid_sequence
MPSGFQQIGSEDGEPPQQRVTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNETWLGRQGPEGPSSIPPGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLVNNVLAVLGGSLMGLANAAASYEMLILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILIAQVLGLESLLGTASLWPLLLGLTVLPALLQLVLLPFCPESPRYLYIIQNLEGPARKSLKRLTGWADVSGVLAELKDEKRKLERERPLSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFETAGVGQPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTSNFIIGMGFQYVAEAMGPYVFLLFAVLLLGFFIFTFLRVPETRGRTFDQISAAFHRTPSLLEQEVKPSTELEYLGPDEND
uniprot
proteins
disease_involvement
DISEASE: Type 2 diabetes mellitus (T2D) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269|PubMed:1521731, ECO:0000269|PubMed:1756912, ECO:0000269|PubMed:1918382}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell. {ECO:0000250|UniProtKB:P19357}.
uniprot
proteins
mass_dalton
54787
uniprot
proteins
mutagenesis
MUTAGEN 223; /note="C->S: Loss of palmitoylation."; /evidence="ECO:0000269|PubMed:28057756"; MUTAGEN 489..490; /note="LL->AA: Changes subcellular location mainly to the plasma membrane."; /evidence="ECO:0000269|PubMed:8300557
uniprot
proteins
post_translational_modification
PTM: Sumoylated. {ECO:0000269|PubMed:11842083}.; PTM: Palmitoylated (PubMed:28057756). Palmitoylation by ZDHHC7 controls the insulin-dependent translocation of GLUT4 to the plasma membrane (PubMed:28057756). {ECO:0000269|PubMed:28057756}.
uniprot
proteins
protein_family
Glucose transporter subfamily
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Sugar transporter (TC 2.A.1.1) family
uniprot
proteins
pubmed
11842083
uniprot
proteins
pubmed
1397719
uniprot
proteins
pubmed
1521731
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16647043
uniprot
proteins
pubmed
17382906
uniprot
proteins
pubmed
1756912
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
1918382
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
2656669
uniprot
proteins
pubmed
28057756
uniprot
proteins
pubmed
7916714
uniprot
proteins
pubmed
8300557
uniprot
proteins
sequence_length
509
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P14142}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P14142}. Endomembrane system {ECO:0000269|PubMed:8300557}; Multi-pass membrane protein {ECO:0000269|PubMed:8300557}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P14142}. Note=Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized (PubMed:8300557). The dileucine internalization motif is critical for intracellular sequestration (PubMed:8300557). Insulin stimulation induces translocation to the cell membrane (By similarity). {ECO:0000250|UniProtKB:P14142, ECO:0000269|PubMed:8300557}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..45; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 82..102; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 112..132; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 143..163; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 172..192; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 202..222; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 288..308; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 324..344; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 354..374; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 385..405; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 418..438; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 446..466; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins