TSC22D1
entrez
8848
canonical
uniprot
Q15714
canonical
ensembl
ENSG00000102804
resolver
ensp
ENSP00000261489
resolver
ensp
ENSP00000397435
resolver
ensp
ENSP00000481585
resolver
ensp
ENSP00000483407
resolver
ensp
ENSP00000541425
resolver
ensp
ENSP00000541426
resolver
ensp
ENSP00000727130
resolver
ensp
ENSP00000795176
resolver
genesymbol
TSC22D1
resolver
genesymbol_syn
KIAA1994
resolver
genesymbol_syn
TGFB1I4
resolver
genesymbol_syn
TSC22
resolver
hgnc
HGNC:16826
resolver
uniprot
A0A087X0H8
resolver
uniprot
A8K3Y6
resolver
uniprot
B3KRL7
resolver
uniprot
B9EGI0
resolver
uniprot
O00666
resolver
uniprot
Q6AHX5
resolver
uniprot
Q6IBU1
resolver
uniprot
Q8NCN1
resolver
uniprot
Q96JS5
resolver
uniprot_entry
A8K3Y6_HUMAN
resolver
uniprot_entry
T22D1_HUMAN
resolver
uniprot_sec
A0A087X0H8
resolver
uniprot_sec
B3KRL7
resolver
uniprot_sec
B9EGI0
resolver
uniprot_sec
O00666
resolver
uniprot_sec
Q6AHX5
resolver
uniprot_sec
Q6IBU1
resolver
uniprot_sec
Q8NCN1
resolver
uniprot_sec
Q96JS5
resolver
amino_acid_sequence
MHQPPESTAAAAAAADISARKMAHPAMFPRRGSGSGSASALNAAGTGVGSNATSSEDFPPPSLLQPPPPAASSTSGPQPPPPQSLNLLSQAQLQAQPLAPGGTQMKKKSGFQITSVTPAQISASISSNNSIAEDTESYDDLDESHTEDLSSSEILDVSLSRATDLGEPERSSSEETLNNFQEAETPGAVSPNQPHLPQPHLPHLPQQNVVINGNAHPHHLHHHHQIHHGHHLQHGHHHPSHVAVASASITGGPPSSPVSRKLSTTGSSDSITPVAPTSAVSSSGSPASVMTNMRAPSTTGGIGINSVTGTSTVNNVNITAVGSFNPNVTSSMLGNVNISTSNIPSAAGVSVGPGVTSGVNVNILSGMGNGTISSSAAVSSVPNAAAGMTGGSVSSQQQQPTVNTSRFRVVKLDSSSEPFKKGRWTCTEFYEKENAVPATEGVLINKVVETVKQNPIEVTSERESTSGSSVSSSVSTLSHYTESVGSGEMGAPTVVVQQQQQQQQQQQQQPALQGVTLQQMDFGSTGPQSIPAVSIPQSISQSQISQVQLQSQELSYQQKQGLQPVPLQATMSAATGIQPSPVNVVGVTSALGQQPSISSLAQPQLPYSQAAPPVQTPLPGAPPPQQLQYGQQQPMVSTQMAPGHVKSVTQNPASEYVQQQPILQTAMSSGQPSSAGVGAGTTVIPVAQPQGIQLPVQPTAVPAQPAGASVQPVGQAPAAVSAVPTGSQIANIGQQANIPTAVQQPSTQVPPSVIQQGAPPSSQVVPPAQTGIIHQGVQTSAPSLPQQLVIASQSSLLTVPPQPQGVEPVAQGIVSQQLPAVSSLPSASSISVTSQVSSTGPSGMPSAPTNLVPPQNIAQTPATQNGNLVQSVSQPPLIATNTNLPLAQQIPLSSTQFSAQSLAQAIGSQIEDARRAAEPSLVGLPQTISGDSGGMSAVSDGSSSSLAASASLFPLKVLPLTTPLVDGEDESSSGASVVAIDNKIEQAMDLVKSHLMYAVREEVEVLKEQIKELIEKNSQLEQENNLLKTLASPEQLAQFQAQLQTGSPPATTQPQGTTQPPAQPASQGSGPTA
uniprot
proteins
function
FUNCTION: Transcriptional repressor (PubMed:10488076). Acts on the C-type natriuretic peptide (CNP) promoter (PubMed:9022669). Acts to promote CASP3-mediated apoptosis (PubMed:18325344). Positively regulates TGF-beta signaling by interacting with SMAD7 which inhibits binding of SMAD7 to TGFBR1, preventing recruitment of SMURF ubiquitin ligases to TGFBR1 and inhibiting SMURF-mediated ubiquitination and degradation of TGFBR1 (PubMed:21791611). Contributes to enhancement of TGF-beta signaling by binding to and modulating the transcription activator activity of SMAD4 (PubMed:15881652). Promotes TGF-beta-induced transcription of COL1A2; via its interaction with TFE3 at E-boxes in the gene proximal promoter (By similarity). Plays a role in the repression of hematopoietic precursor cell growth (By similarity). Promotes IL2 deprivation-induced apoptosis in T-lymphocytes, via repression of TSC22D3/GILZ transcription and activation of the caspase cascade (PubMed:26752201). {ECO:0000250|UniProtKB:P62500, ECO:0000269|PubMed:10488076, ECO:0000269|PubMed:15881652, ECO:0000269|PubMed:18325344, ECO:0000269|PubMed:21791611, ECO:0000269|PubMed:26752201, ECO:0000269|PubMed:9022669}.; FUNCTION: [Isoform 1]: May act to negatively regulate TGFB3 signaling and thereby inhibit cell death in mammary gland cells. {ECO:0000250|UniProtKB:P62500}.; FUNCTION: [Isoform 2]: Positively regulates cell death in response to TGFB3 during mammary gland involution. {ECO:0000250|UniProtKB:P62500}.
uniprot
proteins
mass_dalton
109677
uniprot
proteins
protein_family
TSC-22/Dip/Bun family
uniprot
proteins
pubmed
10488076
uniprot
proteins
pubmed
12056414
uniprot
proteins
pubmed
12468551
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15881652
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18325344
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21448135
uniprot
proteins
pubmed
21791611
uniprot
proteins
pubmed
26752201
uniprot
proteins
pubmed
34681573
uniprot
proteins
pubmed
8651929
uniprot
proteins
pubmed
9022669
uniprot
proteins
pubmed
9026990
uniprot
proteins
sequence_length
1073
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21791611}. Nucleus {ECO:0000250|UniProtKB:P62500}. Cell membrane {ECO:0000269|PubMed:21791611}; Peripheral membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:34681573}. Nucleus {ECO:0000269|PubMed:34681573}. Mitochondrion {ECO:0000269|PubMed:34681573}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:34681573}. Nucleus {ECO:0000269|PubMed:34681573}. Mitochondrion {ECO:0000269|PubMed:34681573}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:34681573}. Nucleus {ECO:0000269|PubMed:34681573}.
uniprot
proteins