TSPYL2
entrez
64061
canonical
uniprot
Q9H2G4
canonical
ensembl
ENSG00000184205
resolver
ensp
ENSP00000364591
resolver
ensp
ENSP00000636807
resolver
ensp
ENSP00000701752
resolver
enst
ENST00000375442
resolver
genesymbol
TSPYL2
resolver
genesymbol_syn
CDA1
resolver
genesymbol_syn
DENTT
resolver
genesymbol_syn
TSPX
resolver
hgnc
HGNC:24358
resolver
uniprot
O94799
resolver
uniprot
Q96DG7
resolver
uniprot
Q9BZW6
resolver
uniprot_entry
TSYL2_HUMAN
resolver
uniprot_sec
O94799
resolver
uniprot_sec
Q96DG7
resolver
uniprot_sec
Q9BZW6
resolver
amino_acid_sequence
MDRPDEGPPAKTRRLSSSESPQRDPPPPPPPPPLLRLPLPPPQQRPRLQEETEAAQVLADMRGVGLGPALPPPPPYVILEEGGIRAYFTLGAECPGWDSTIESGYGEAPPPTESLEALPTPEASGGSLEIDFQVVQSSSFGGEGALETCSAVGWAPQRLVDPKSKEEAIIIVEDEDEDERESMRSSRRRRRRRRRKQRKVKRESRERNAERMESILQALEDIQLDLEAVNIKAGKAFLRLKRKFIQMRRPFLERRDLIIQHIPGFWVKAFLNHPRISILINRRDEDIFRYLTNLQVQDLRHISMGYKMKLYFQTNPYFTNMVIVKEFQRNRSGRLVSHSTPIRWHRGQEPQARRHGNQDASHSFFSWFSNHSLPEADRIAEIIKNDLWVNPLRYYLRERGSRIKRKKQEMKKRKTRGRCEVVIMEDAPDYYAVEDIFSEISDIDETIHDIKISDFMETTDYFETTDNEITDINENICDSENPDHNEVPNNETTDNNESADDHETTDNNESADDNNENPEDNNKNTDDNEENPNNNENTYGNNFFKGGFWGSHGNNQDSSDSDNEADEASDDEDNDGNEGDNEGSDDDGNEGDNEGSDDDDRDIEYYEKVIEDFDKDQADYEDVIEIISDESVEEEGIEEGIQQDEDIYEEGNYEEEGSEDVWEEGEDSDDSDLEDVLQVPNGWANPGKRGKTG
uniprot
proteins
function
FUNCTION: Part of the CASK/TBR1/TSPYL2 transcriptional complex which modulates gene expression in response to neuronal synaptic activity, probably by facilitating nucleosome assembly. May inhibit cell proliferation by inducing p53-dependent CDKN1A expression. {ECO:0000269|PubMed:11395479, ECO:0000269|PubMed:17317670}.
uniprot
proteins
mass_dalton
79435
uniprot
proteins
mutagenesis
MUTAGEN 20; /note="S->A: Impairs effect on cell proliferation; when associated with A-340."; /evidence="ECO:0000269|PubMed:11395479"; MUTAGEN 340; /note="T->A: Impairs effect on cell proliferation; when associated with A-20."; /evidence="ECO:0000269|PubMed:11395479
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-20 and/or Thr-340 impairs function on cell proliferation. {ECO:0000305|PubMed:11395479}.
uniprot
proteins
protein_family
Nucleosome assembly protein (NAP) family
uniprot
proteins
pubmed
11149944
uniprot
proteins
pubmed
11318608
uniprot
proteins
pubmed
11395479
uniprot
proteins
pubmed
12393179
uniprot
proteins
pubmed
15069065
uniprot
proteins
pubmed
15241014
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
15823505
uniprot
proteins
pubmed
17317670
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
26529358
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
9853615
uniprot
proteins
sequence_length
693
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11318608, ECO:0000269|PubMed:11395479}. Cytoplasm {ECO:0000250}. Note=Enriched in transcriptionally active regions of chromatin in neurons. {ECO:0000250}.
uniprot
proteins