ELAC1
entrez
55520
canonical
uniprot
Q9H777
canonical
ensembl
ENSG00000141642
resolver
ensp
ENSP00000269466
resolver
ensp
ENSP00000528994
resolver
ensp
ENSP00000528995
resolver
ensp
ENSP00000528997
resolver
ensp
ENSP00000528998
resolver
ensp
ENSP00000632001
resolver
ensp
ENSP00000632002
resolver
ensp
ENSP00000632003
resolver
enst
ENST00000269466
resolver
enst
ENST00000858935
resolver
enst
ENST00000858936
resolver
enst
ENST00000858938
resolver
enst
ENST00000858939
resolver
enst
ENST00000961942
resolver
enst
ENST00000961943
resolver
enst
ENST00000961944
resolver
genesymbol
ELAC1
resolver
genesymbol_syn
D29
resolver
hgnc
HGNC:14197
resolver
uniprot
Q9NS99
resolver
uniprot_entry
RNZ1_HUMAN
resolver
uniprot_sec
Q9NS99
resolver
amino_acid_sequence
MSMDVTFLGTGAAYPSPTRGASAVVLRCEGECWLFDCGEGTQTQLMKSQLKAGRITKIFITHLHGDHFFGLPGLLCTISLQSGSMVSKQPIEIYGPVGLRDFIWRTMELSHTELVFHYVVHELVPTADQCPAEELKEFAHVNRADSPPKEEQGRTILLDSEENSYLLFDDEQFVVKAFRLFHRIPSFGFSVVEKKRPGKLNAQKLKDLGVPPGPAYGKLKNGISVVLENGVTISPQDVLKKPIVGRKICILGDCSGVVGDGGVKLCFEADLLIHEATLDDAQMDKAKEHGHSTPQMAATFAKLCRAKRLVLTHFSQRYKPVALAREGETDGIAELKKQAESVLDLQEVTLAEDFMVISIPIKK
uniprot
proteins
ec_number
3.1.26.11
uniprot
proteins
function
FUNCTION: Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity (PubMed:12711671, PubMed:32075755). Specifically involved in tRNA repair: acts downstream of the ribosome-associated quality control (RQC) pathway by removing a 2',3'-cyclic phosphate from tRNAs following cleavage by ANKZF1 (PubMed:32075755). tRNAs are then processed by TRNT1 (PubMed:32075755). {ECO:0000269|PubMed:12711671, ECO:0000269|PubMed:32075755}.
uniprot
proteins
mass_dalton
40019
uniprot
proteins
mutagenesis
MUTAGEN 64; /note="H->A: Abolsihed tRNase activity and ability to repair tRNAs downstream of ANKZF1."; /evidence="ECO:0000269|Ref.8
uniprot
proteins
protein_family
RNase Z family
uniprot
proteins
pubmed
11175785
uniprot
proteins
pubmed
11401430
uniprot
proteins
pubmed
12711671
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21593607
uniprot
proteins
pubmed
32075755
uniprot
proteins
sequence_length
363
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:21593607}. Nucleus {ECO:0000269|PubMed:21593607}. Note=Mainly cytosolic. {ECO:0000269|PubMed:21593607}.
uniprot
proteins