SLC28A2
entrez
9153
canonical
uniprot
O43868
canonical
ensembl
ENSG00000137860
resolver
ensp
ENSP00000315006
resolver
ensp
ENSP00000629778
resolver
enst
ENST00000347644
resolver
enst
ENST00000959719
resolver
genesymbol
SLC28A2
resolver
genesymbol_syn
CNT2
resolver
hgnc
HGNC:11002
resolver
uniprot
A8K7F9
resolver
uniprot
O43239
resolver
uniprot
Q2M2A7
resolver
uniprot
Q52LZ0
resolver
uniprot
Q53H72
resolver
uniprot_entry
Q2M2A7_HUMAN
resolver
uniprot_entry
Q53H72_HUMAN
resolver
uniprot_entry
S28A2_HUMAN
resolver
uniprot_sec
A8K7F9
resolver
uniprot_sec
O43239
resolver
uniprot_sec
Q52LZ0
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by formycin B. {ECO:0000269|PubMed:9435697}.
uniprot
proteins
amino_acid_sequence
MEKASGRQSIALSTVETGTVNPGLELMEKEVEPEGSKRTDAQGHSLGDGLGPSTYQRRSRWPFSKARSFCKTHASLFKKILLGLLCLAYAAYLLAACILNFQRALALFVITCLVIFVLVHSFLKKLLGKKLTRCLKPFENSRLRLWTKWVFAGVSLVGLILWLALDTAQRPEQLIPFAGICMFILILFACSKHHSAVSWRTVFSGLGLQFVFGILVIRTDLGYTVFQWLGEQVQIFLNYTVAGSSFVFGDTLVKDVFAFQALPIIIFFGCVVSILYYLGLVQWVVQKVAWFLQITMGTTATETLAVAGNIFVGMTEAPLLIRPYLGDMTLSEIHAVMTGGFATISGTVLGAFIAFGVDASSLISASVMAAPCALASSKLAYPEVEESKFKSEEGVKLPRGKERNVLEAASNGAVDAIGLATNVAANLIAFLAVLAFINAALSWLGELVDIQGLTFQVICSYLLRPMVFMMGVEWTDCPMVAEMVGIKFFINEFVAYQQLSQYKNKRLSGMEEWIEGEKQWISVRAEIITTFSLCGFANLSSIGITLGGLTSIVPHRKSDLSKVVVRALFTGACVSLISACMAGILYVPRGAEADCVSFPNTSFTNRTYETYMCCRGLFQSTSLNGTNPPSFSGPWEDKEFSAMALTNCCGFYNNTVCA
uniprot
proteins
function
FUNCTION: Sodium-dependent and purine-selective transporter (PubMed:10087507, PubMed:9435697). Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine) (PubMed:10087507, PubMed:21795683, PubMed:9435697). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues (PubMed:9435697). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). {ECO:0000269|PubMed:10087507, ECO:0000269|PubMed:21795683, ECO:0000269|PubMed:9435697, ECO:0000305|PubMed:35307651}.
uniprot
proteins
mass_dalton
71926
uniprot
proteins
protein_family
Concentrative nucleoside transporter (CNT) (TC 2.A.41) family
uniprot
proteins
pubmed
10087507
uniprot
proteins
pubmed
10455109
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15861032
uniprot
proteins
pubmed
17700367
uniprot
proteins
pubmed
21795683
uniprot
proteins
pubmed
35307651
uniprot
proteins
pubmed
9435697
uniprot
proteins
sequence_length
658
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:9435697}; Multi-pass membrane protein {ECO:0000255}. Apicolateral cell membrane {ECO:0000269|PubMed:35307651}; Multi-pass membrane protein {ECO:0000255}. Note=Localized to the apicolateral membranes of Sertoli cells and vascular endothelial cells in testis. {ECO:0000269|PubMed:35307651}.
uniprot
proteins
transmembrane_region
TRANSMEM 80..100; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 104..123; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 148..166; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 172..192; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 200..220; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 233..253; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 260..280; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 295..314; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 336..355; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 362..381; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 423..443; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 454..474; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 529..549; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 567..587; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins