TMEM150C
entrez
441027
canonical
uniprot
B9EJG8
canonical
ensembl
ENSG00000249242
resolver
ensp
ENSP00000403438
resolver
ensp
ENSP00000679477
resolver
genesymbol
TMEM150C
resolver
genesymbol_syn
TTN3
resolver
hgnc
HGNC:37263
resolver
uniprot
B7Z4J5
resolver
uniprot
B7Z4L3
resolver
uniprot
B7Z692
resolver
uniprot
B7Z6X6
resolver
uniprot_entry
T150C_HUMAN
resolver
uniprot_sec
B7Z4J5
resolver
uniprot_sec
B7Z4L3
resolver
uniprot_sec
B7Z692
resolver
uniprot_sec
B7Z6X6
resolver
amino_acid_sequence
MDGKKCSVWMFLPLVFTLFTSAGLWIVYFIAVEDDKILPLNSAERKPGVKHAPYISIAGDDPPASCVFSQVMNMAAFLALVVAVLRFIQLKPKVLNPWLNISGLVALCLASFGMTLLGNFQLTNDEEIHNVGTSLTFGFGTLTCWIQAALTLKVNIKNEGRRVGIPRVILSASITLCVVLYFILMAQSIHMYAARVQWGLVMCFLSYFGTFAVEFRHYRYEIVCSEYQENFLSFSESLSEASEYQTDQV
uniprot
proteins
function
FUNCTION: Nonselective cationic channel with high permeability to Ca(2+). Component of a mechanosensitive cation channel, confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception. {ECO:0000250|UniProtKB:Q8C8S3}.
uniprot
proteins
mass_dalton
27887
uniprot
proteins
protein_family
DRAM/TMEM150 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
25608530
uniprot
proteins
sequence_length
249
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25608530}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000305|PubMed:25608530}; Multi-pass membrane protein {ECO:0000305}. Note=Localizes at the plasma membrane. A portion co-localizes with LAMP1 lysosomal marker (PubMed:25608530). {ECO:0000269|PubMed:25608530}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..30; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 65..85; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 98..118; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 131..151; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 169..189; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 193..213; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins