PLIN3
entrez
10226
canonical
uniprot
O60664
canonical
ensembl
ENSG00000105355
resolver
ensp
ENSP00000221957
resolver
ensp
ENSP00000465596
resolver
ensp
ENSP00000467803
resolver
genesymbol
PLIN3
resolver
genesymbol_syn
M6PRBP1
resolver
genesymbol_syn
TIP47
resolver
hgnc
HGNC:16893
resolver
uniprot
A0A140VJN8
resolver
uniprot
A8K4Y9
resolver
uniprot
K7EQF4
resolver
uniprot
Q53G77
resolver
uniprot
Q9BS03
resolver
uniprot
Q9UBD7
resolver
uniprot
Q9UP92
resolver
uniprot_entry
A0A140VJN8_HUMAN
resolver
uniprot_entry
PLIN3_HUMAN
resolver
uniprot_sec
A8K4Y9
resolver
uniprot_sec
K7EQF4
resolver
uniprot_sec
Q53G77
resolver
uniprot_sec
Q9BS03
resolver
uniprot_sec
Q9UBD7
resolver
uniprot_sec
Q9UP92
resolver
amino_acid_sequence
MSADGAEADGSTQVTVEEPVQQPSVVDRVASMPLISSTCDMVSAAYASTKESYPHIKTVCDAAEKGVRTLTAAAVSGAQPILSKLEPQIASASEYAHRGLDKLEENLPILQQPTEKVLADTKELVSSKVSGAQEMVSSAKDTVATQLSEAVDATRGAVQSGVDKTKSVVTGGVQSVMGSRLGQMVLSGVDTVLGKSEEWADNHLPLTDAELARIATSLDGFDVASVQQQRQEQSYFVRLGSLSERLRQHAYEHSLGKLRATKQRAQEALLQLSQVLSLMETVKQGVDQKLVEGQEKLHQMWLSWNQKQLQGPEKEPPKPEQVESRALTMFRDIAQQLQATCTSLGSSIQGLPTNVKDQVQQARRQVEDLQATFSSIHSFQDLSSSILAQSRERVASAREALDHMVEYVAQNTPVTWLVGPFAPGITEKAPEEKK
uniprot
proteins
function
FUNCTION: Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets (PubMed:34077757). Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (PubMed:9590177). {ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:9590177}.
uniprot
proteins
mass_dalton
47075
uniprot
proteins
mutagenesis
MUTAGEN 251; /note="Y->F: Abolished phosphorylation at Tyr-232 by isoform 1 of CHKA (CHKalpha2)."; /evidence="ECO:0000269|PubMed:34077757
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Tyr-251 by isoform 1 of CHKA (CHKalpha2) promotes dissociation from lipid droplets: dissociation is followed by recruitment of autophagosome machinery to lipid droplets and subsequent lipid droplet lipolysis. {ECO:0000269|PubMed:34077757}.
uniprot
proteins
protein_family
Perilipin family
uniprot
proteins
pubmed
10393528
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15545278
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26357594
uniprot
proteins
pubmed
34077757
uniprot
proteins
pubmed
37443287
uniprot
proteins
pubmed
6856484
uniprot
proteins
pubmed
9590177
uniprot
proteins
pubmed
9874244
uniprot
proteins
sequence_length
434
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lipid droplet {ECO:0000269|PubMed:15545278, ECO:0000269|PubMed:34077757, ECO:0000269|PubMed:37443287}. Endosome membrane {ECO:0000269|PubMed:15545278}; Peripheral membrane protein {ECO:0000269|PubMed:15545278}; Cytoplasmic side {ECO:0000269|PubMed:15545278}. Cytoplasm {ECO:0000269|PubMed:15545278, ECO:0000269|PubMed:26357594, ECO:0000269|PubMed:9590177}. Note=Membrane associated on endosomes (PubMed:15545278). Detected in the envelope and the core of lipid bodies and in lipid sails (PubMed:15545278). {ECO:0000269|PubMed:15545278}.
uniprot
proteins