FAM20B
entrez
9917
canonical
uniprot
O75063
canonical
ensembl
ENSG00000116199
resolver
ensp
ENSP00000263733
resolver
ensp
ENSP00000559670
resolver
ensp
ENSP00000599197
resolver
enst
ENST00000263733
resolver
enst
ENST00000889611
resolver
enst
ENST00000929138
resolver
genesymbol
FAM20B
resolver
genesymbol_syn
KIAA0475
resolver
hgnc
HGNC:23017
resolver
uniprot
Q5W0C3
resolver
uniprot
Q5W0C4
resolver
uniprot_entry
XYLK_HUMAN
resolver
uniprot_sec
Q5W0C3
resolver
uniprot_sec
Q5W0C4
resolver
amino_acid_sequence
MKLKQRVVLLAILLVIFIFTKVFLIDNLDTSAANREDQRAFHRMMTGLRVELAPKLDHTLQSPWEIAAQWVVPREVYPEETPELGAVMHAMATKKIIKADVGYKGTQLKALLILEGGQKVVFKPKRYSRDHVVEGEPYAGYDRHNAEVAAFHLDRILGFHRAPLVVGRFVNLRTEIKPVATEQLLSTFLTVGNNTCFYGKCYYCRETEPACADGDIMEGSVTLWLPDVWPLQKHRHPWGRTYREGKLARWEYDESYCDAVKKTSPYDSGPRLLDIIDTAVFDYLIGNADRHHYESFQDDEGASMLILLDNAKSFGNPSLDERSILAPLYQCCIIRVSTWNRLNYLKNGVLKSALKSAMAHDPISPVLSDPHLDAVDQRLLSVLATVKQCTDQFGMDTVLVEDRMPLSHL
uniprot
proteins
ec_number
2.7.1.-
uniprot
proteins
function
FUNCTION: Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-O-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized. {ECO:0000269|PubMed:19473117, ECO:0000269|PubMed:24425863}.
uniprot
proteins
mass_dalton
46432
uniprot
proteins
protein_family
FAM20 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15676076
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18400750
uniprot
proteins
pubmed
19473117
uniprot
proteins
pubmed
24425863
uniprot
proteins
pubmed
9455484
uniprot
proteins
sequence_length
409
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:19473117}; Single-pass type II membrane protein {ECO:0000269|PubMed:19473117}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..25; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins