PELP1
entrez
27043
canonical
uniprot
Q8IZL8
canonical
ensembl
ENSG00000141456
resolver
ensp
ENSP00000301396
resolver
ensp
ENSP00000416231
resolver
ensp
ENSP00000460300
resolver
ensp
ENSP00000461625
resolver
enst
ENST00000301396
resolver
enst
ENST00000436683
resolver
enst
ENST00000572293
resolver
enst
ENST00000574876
resolver
genesymbol
PELP1
resolver
genesymbol_syn
HMX3
resolver
genesymbol_syn
MNAR
resolver
hgnc
HGNC:30134
resolver
uniprot
B4DEX7
resolver
uniprot
B4DR36
resolver
uniprot
C9JFV4
resolver
uniprot
E7EV54
resolver
uniprot
I3L3A8
resolver
uniprot
O15450
resolver
uniprot
Q5EGN3
resolver
uniprot
Q6NTE6
resolver
uniprot
Q96FT1
resolver
uniprot
Q9BU60
resolver
uniprot_entry
B4DEX7_HUMAN
resolver
uniprot_entry
B4DR36_HUMAN
resolver
uniprot_entry
C9JFV4_HUMAN
resolver
uniprot_entry
E7EV54_HUMAN
resolver
uniprot_entry
PELP1_HUMAN
resolver
uniprot_sec
I3L3A8
resolver
uniprot_sec
O15450
resolver
uniprot_sec
Q5EGN3
resolver
uniprot_sec
Q6NTE6
resolver
uniprot_sec
Q96FT1
resolver
uniprot_sec
Q9BU60
resolver
amino_acid_sequence
MAAAVLSGPSAGSAAGVPGGTGGLSAVSSGPRLRLLLLESVSGLLQPRTGSAVAPVHPPNRSAPHLPGLMCLLRLHGSVGGAQNLSALGALVSLSNARLSSIKTRFEGLCLLSLLVGESPTELFQQHCVSWLRSIQQVLQTQDPPATMELAVAVLRDLLRYAAQLPALFRDISMNHLPGLLTSLLGLRPECEQSALEGMKACMTYFPRACGSLKGKLASFFLSRVDALSPQLQQLACECYSRLPSLGAGFSQGLKHTESWEQELHSLLASLHTLLGALYEGAETAPVQNEGPGVEMLLSSEDGDAHVLLQLRQRFSGLARCLGLMLSSEFGAPVSVPVQEILDFICRTLSVSSKNISLHGDGPLRLLLLPSIHLEALDLLSALILACGSRLLRFGILIGRLLPQVLNSWSIGRDSLSPGQERPYSTVRTKVYAILELWVQVCGASAGMLQGGASGEALLTHLLSDISPPADALKLRSPRGSPDGSLQTGKPSAPKKLKLDVGEAMAPPSHRKGDSNANSDVCAAALRGLSRTILMCGPLIKEETHRRLHDLVLPLVMGVQQGEVLGSSPYTSSRCRRELYCLLLALLLAPSPRCPPPLACALQAFSLGQREDSLEVSSFCSEALVTCAALTHPRVPPLQPMGPTCPTPAPVPPPEAPSPFRAPPFHPPGPMPSVGSMPSAGPMPSAGPMPSAGPVPSARPGPPTTANHLGLSVPGLVSVPPRLLPGPENHRAGSNEDPILAPSGTPPPTIPPDETFGGRVPRPAFVHYDKEEASDVEISLESDSDDSVVIVPEGLPPLPPPPPSGATPPPIAPTGPPTASPPVPAKEEPEELPAAPGPLPPPPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEEDEEEEEELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGEVEREGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPPPETPAEEEMETETEAEALQEKEQDDTAAMLADFIDCPPDDEKPPPPTEPDS
uniprot
proteins
function
FUNCTION: Coactivator of estrogen receptor-mediated transcription and a corepressor of other nuclear hormone receptors and sequence-specific transcription factors (PubMed:14963108). Plays a role in estrogen receptor (ER) genomic activity when present in the nuclear compartment by activating the ER target genes in a hormonal stimulation dependent manner. Can facilitate ER non-genomic signaling via SRC and PI3K interaction in the cytosol. Plays a role in E2-mediated cell cycle progression by interacting with RB1. May have important functional implications in ER/growth factor cross-talk. Interacts with several growth factor signaling components including EGFR and HRS. Functions as the key stabilizing component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Component of the PELP1 complex involved in the nucleolar steps of 28S rRNA maturation and the subsequent nucleoplasmic transit of the pre-60S ribosomal subunit. Regulates pre-60S association of the critical remodeling factor MDN1 (PubMed:21326211). May promote tumorigenesis via its interaction with and modulation of several oncogenes including SRC, PI3K, STAT3 and EGFR. Plays a role in cancer cell metastasis via its ability to modulate E2-mediated cytoskeleton changes and cell migration via its interaction with SRC and PI3K. {ECO:0000269|PubMed:11481323, ECO:0000269|PubMed:12682072, ECO:0000269|PubMed:14963108, ECO:0000269|PubMed:15374949, ECO:0000269|PubMed:15456770, ECO:0000269|PubMed:15579769, ECO:0000269|PubMed:15994929, ECO:0000269|PubMed:16140940, ECO:0000269|PubMed:16352611, ECO:0000269|PubMed:16574651, ECO:0000269|PubMed:21326211, ECO:0000269|PubMed:22872859}.
uniprot
proteins
mass_dalton
119700
uniprot
proteins
mutagenesis
MUTAGEN 826; /note="K->R: Not sumoylated."; /evidence="ECO:0000269|PubMed:21326211
uniprot
proteins
post_translational_modification
PTM: Transiently sumoylated, preferentially conjugated to SUMO2 or SUMO3. Sumoylation causes nucleolar exclusion of PELP1 and promotes the recruitment of MDN1 to pre-60S particles. Desumoylation by SUMO isopeptidase SENP3 is needed to release both PELP1 and MDN1 from pre-ribosomes. {ECO:0000269|PubMed:21326211, ECO:0000269|PubMed:27814492}.
uniprot
proteins
protein_family
RIX1/PELP1 family
uniprot
proteins
pubmed
11481323
uniprot
proteins
pubmed
12415108
uniprot
proteins
pubmed
12682072
uniprot
proteins
pubmed
14963108
uniprot
proteins
pubmed
15374949
uniprot
proteins
pubmed
15456770
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15579769
uniprot
proteins
pubmed
15960975
uniprot
proteins
pubmed
15994929
uniprot
proteins
pubmed
16140940
uniprot
proteins
pubmed
16352611
uniprot
proteins
pubmed
16567619
uniprot
proteins
pubmed
16574651
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17505058
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19666546
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21326211
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
22872859
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27814492
uniprot
proteins
sequence_length
1130
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:21326211}. Nucleus, nucleoplasm {ECO:0000269|PubMed:21326211}. Nucleus {ECO:0000269|PubMed:11481323}. Cytoplasm {ECO:0000269|PubMed:11481323}. Note=Mainly found in the nucleoplasm, with low levels detected in the cytoplasm (By similarity). Also found associated with the plasma membrane. Mainly in cytoplasm in a subset of breast tumors. Localization is widely deregulated in endometrial cancers with predominantly cytoplasm localization in high-grade endometrial tumors (PubMed:16140940). {ECO:0000250|UniProtKB:Q9DBD5, ECO:0000269|PubMed:16140940}.
uniprot
proteins