TAS2R14
entrez
50840
canonical
uniprot
Q9NYV8
canonical
ensembl
ENSG00000212127
resolver
ensembl
ENSG00000261984
resolver
ensembl
ENSG00000276541
resolver
ensp
ENSP00000441949
resolver
ensp
ENSP00000458544
resolver
ensp
ENSP00000484251
resolver
enst
ENST00000537503
resolver
enst
ENST00000575008
resolver
enst
ENST00000614274
resolver
genesymbol
TAS2R14
resolver
hgnc
HGNC:14920
resolver
uniprot
Q645X3
resolver
uniprot_entry
T2R14_HUMAN
resolver
uniprot_sec
Q645X3
resolver
activity_regulation
ACTIVITY REGULATION: Basal activity is enhanced by binding to bitter tastants, such as flufenamic acid and aristolochic acid (PubMed:38600377, PubMed:38776963). Regulated by cholesterol in a concentration-dependent manner (PubMed:38600377, PubMed:38776963). {ECO:0000269|PubMed:38600377, ECO:0000269|PubMed:38776963}.
uniprot
proteins
amino_acid_sequence
MGGVIKSIFTFVLIVEFIIGNLGNSFIALVNCIDWVKGRKISSVDRILTALAISRISLVWLIFGSWCVSVFFPALFATEKMFRMLTNIWTVINHFSVWLATGLGTFYFLKIANFSNSIFLYLKWRVKKVVLVLLLVTSVFLFLNIALINIHINASINGYRRNKTCSSDSSNFTRFSSLIVLTSTVFIFIPFTLSLAMFLLLIFSMWKHRKKMQHTVKISGDASTKAHRGVKSVITFFLLYAIFSLSFFISVWTSERLEENLIILSQVMGMAYPSCHSCVLILGNKKLRQASLSVLLWLRYMFKDGEPSGHKEFRESS
uniprot
proteins
function
FUNCTION: Gustducin-linked G protein-coupled receptor that plays a role in the perception of bitterness (PubMed:38600377, PubMed:38776963). The activity of this receptor stimulates GNAT3, activating the gustducin G protein pathway (PubMed:38600377, PubMed:38776963). Likely plays a role in sensing the chemical composition of the gastrointestinal content and other extra-oral tissues via the inhibitory G protein pathways (PubMed:38600377, PubMed:38776963). {ECO:0000269|PubMed:38600377, ECO:0000269|PubMed:38776963}.
uniprot
proteins
mass_dalton
36160
uniprot
proteins
mutagenesis
MUTAGEN 55; /note="R->A: Abolishes calcium mobilization induced by aristolochic acid and flufenamic acid."; /evidence="ECO:0000269|PubMed:38776963"; MUTAGEN 65; /note="S->A: Impairs calcium mobilization induced by aristolochic acid and flufenamic acid. Impairs calcium mobilization; when associated with A-89. Impairs calcium mobilization; when associated with A-180. Abolishes calcium mobilization; when associated with A-89 and A-180."; /evidence="ECO:0000269|PubMed:38776963"; MUTAGEN 82; /note="F->A: Impairs calcium mobilization induced by aristolochic acid and flufenamic acid."; /evidence="ECO:0000269|PubMed:38776963"; MUTAGEN 89; /note="W->A: Abolishes basal activities of TAS2R14-GNAI1 and TAS2R14-GNAT3. Abolishes activation of TAS2R14-GNAT3 by flufenamic acid derivative cmpd28.1. Impairs calcium mobilization induced by aristolochic acid and flufenamic acid. Impairs calcium mobilization; when associated with A-65. Abolishes calcium mobilization; when associated with A-180. Abolishes calcium mobilization; when associated with A-65 and A-180."; /evidence="ECO:0000269|PubMed:38600377, ECO:0000269|PubMed:38776963"; MUTAGEN 104; /note="G->A: Impairs calcium mobilization induced by aristolochic acid, flufenamic acid and flufenamic acid derivative cmpd28.1."; /evidence="ECO:0000269|PubMed:38776963"; MUTAGEN 107; /note="Y->A: Attenuates activation of TAS2R14-GNAT3 and TAS2R14-GNAI1 by flufenamic acid derivative cmpd28.1. Abolishes calcium mobilization induced by aristolochic acid, flufenamic acid and flufenamic acid derivative cmpd28.1."; /evidence="ECO:0000269|PubMed:38600377, ECO:0000269|PubMed:38776963"; MUTAGEN 124; /note="W->A: Impairs calcium mobilization induced by aristolochic acid and flufenamic acid."; /evidence="ECO:0000269|PubMed:38776963"; MUTAGEN 180; /note="V->A: Impairs calcium mobilization induced by aristolochic acid and flufenamic acid. Impairs calcium mobilization; when associated with A-65. Abolishes calcium mobilization; when associated with A-89. Abolishes calcium mobilization; when associated with A-65 and A-89."; /evidence="ECO:0000269|PubMed:38776963"; MUTAGEN 194; /note="S->A: Attenuates activation of TAS2R14-GNAT3 and TAS2R14-GNAI1 by flufenamic acid derivative cmpd28.1. Impairs calcium mobilization induced by aristolochic acid, flufenamic acid and flufenamic acid derivative cmpd28.1."; /evidence="ECO:0000269|PubMed:38600377, ECO:0000269|PubMed:38776963"; MUTAGEN 198; /note="F->A: Impairs calcium mobilization induced by aristolochic acid, flufenamic acid and flufenamic acid derivative cmpd28.1."; /evidence="ECO:0000269|PubMed:38776963"; MUTAGEN 205; /note="M->A,L: Impairs calcium mobilization induced by aristolochic acid and flufenamic acid. Impairs calcium mobilization; when associated with A-230."; /evidence="ECO:0000269|PubMed:38776963"; MUTAGEN 208; /note="H->A: Impairs calcium mobilization induced by aristolochic acid and flufenamic acid."; /evidence="ECO:0000269|PubMed:38776963"; MUTAGEN 229; /note="G->A,F: Abolishes calcium mobilization induced by aristolochic acid. Impairs calcium mobilization induced by flufenamic acid and flufenamic acid derivative cmpd28.1."; /evidence="ECO:0000269|PubMed:38776963"; MUTAGEN 230; /note="V->A: Impairs calcium mobilization induced by aristolochic acid and flufenamic acid. Impairs calcium mobilization; when associated with A-205 or L-205."; /evidence="ECO:0000269|PubMed:38776963"; MUTAGEN 233; /note="V->A,W,F: Impairs calcium mobilization induced by aristolochic acid, flufenamic acid and flufenamic acid derivative cmpd28.1."; /evidence="ECO:0000269|PubMed:38776963"; MUTAGEN 236; /note="F->A: Attenuates activation of TAS2R14-GNAT3 and TAS2R14-GNAI1 flufenamic acid derivative cmpd28.1."; /evidence="ECO:0000269|PubMed:38600377"; MUTAGEN 237; /note="F->A: Impairs calcium mobilization induced by aristolochic acid and flufenamic acid."; /evidence="ECO:0000269|PubMed:38776963"; MUTAGEN 240; /note="Y->A: Attenuates activation of TAS2R14-GNAT3 and TAS2R14-GNAI1 by flufenamic acid derivative cmpd28.1. Abolishes calcium mobilization induced by aristolochic acid and flufenamic acid."; /evidence="ECO:0000269|PubMed:38600377, ECO:0000269|PubMed:38776963"; MUTAGEN 266; /note="Q->A: Impairs calcium mobilization induced by aristolochic acid and flufenamic acid."; /evidence="ECO:0000269|PubMed:38776963"; MUTAGEN 269; /note="G->A,I: Impairs calcium mobilization induced by aristolochic acid and flufenamic acid."; /evidence="ECO:0000269|PubMed:38776963"; MUTAGEN 272; /note="Y->A: Impairs calcium mobilization induced by aristolochic acid and flufenamic acid."; /evidence="ECO:0000269|PubMed:38776963"; MUTAGEN 276; /note="H->A: Attenuates activation of TAS2R14-GNAT3 and TAS2R14-GNAI1 by flufenamic acid derivative cmpd28.1. Abolishes calcium mobilization induced by aristolochic acid, flufenamic acid and flufenamic acid derivative cmpd28.1."; /evidence="ECO:0000269|PubMed:38600377, ECO:0000269|PubMed:38776963
uniprot
proteins
protein_family
G protein-coupled receptor T2R family
uniprot
proteins
pubmed
10761934
uniprot
proteins
pubmed
10761935
uniprot
proteins
pubmed
11696554
uniprot
proteins
pubmed
12139982
uniprot
proteins
pubmed
12581520
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15496549
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
16720576
uniprot
proteins
pubmed
38600377
uniprot
proteins
pubmed
38776963
uniprot
proteins
sequence_length
317
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein {ECO:0000269|PubMed:38600377, ECO:0000269|PubMed:38776963}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:38600377, ECO:0000269|PubMed:38776963, ECO:0007744|PDB:8VY7, ECO:0007744|PDB:8VY9, ECO:0007744|PDB:8XQL, ECO:0007744|PDB:8XQN, ECO:0007744|PDB:8XQO, ECO:0007744|PDB:8XQP, ECO:0007744|PDB:8XQR, ECO:0007744|PDB:8XQS, ECO:0007744|PDB:8XQT, ECO:0007744|PDB:8YKY"; TRANSMEM 56..76; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:38600377, ECO:0000269|PubMed:38776963, ECO:0007744|PDB:8VY7, ECO:0007744|PDB:8VY9, ECO:0007744|PDB:8XQL, ECO:0007744|PDB:8XQN, ECO:0007744|PDB:8XQO, ECO:0007744|PDB:8XQP, ECO:0007744|PDB:8XQR, ECO:0007744|PDB:8XQS, ECO:0007744|PDB:8XQT, ECO:0007744|PDB:8YKY"; TRANSMEM 88..108; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:38600377, ECO:0000269|PubMed:38776963, ECO:0007744|PDB:8VY7, ECO:0007744|PDB:8VY9, ECO:0007744|PDB:8XQL, ECO:0007744|PDB:8XQN, ECO:0007744|PDB:8XQO, ECO:0007744|PDB:8XQP, ECO:0007744|PDB:8XQR, ECO:0007744|PDB:8XQS, ECO:0007744|PDB:8XQT, ECO:0007744|PDB:8YKY"; TRANSMEM 130..150; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:38600377, ECO:0000269|PubMed:38776963, ECO:0007744|PDB:8VY7, ECO:0007744|PDB:8VY9, ECO:0007744|PDB:8XQL, ECO:0007744|PDB:8XQN, ECO:0007744|PDB:8XQO, ECO:0007744|PDB:8XQP, ECO:0007744|PDB:8XQR, ECO:0007744|PDB:8XQS, ECO:0007744|PDB:8XQT, ECO:0007744|PDB:8YKY"; TRANSMEM 185..205; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:38600377, ECO:0000269|PubMed:38776963, ECO:0007744|PDB:8VY7, ECO:0007744|PDB:8VY9, ECO:0007744|PDB:8XQL, ECO:0007744|PDB:8XQN, ECO:0007744|PDB:8XQO, ECO:0007744|PDB:8XQP, ECO:0007744|PDB:8XQR, ECO:0007744|PDB:8XQS, ECO:0007744|PDB:8XQT, ECO:0007744|PDB:8YKY"; TRANSMEM 233..253; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:38600377, ECO:0000269|PubMed:38776963, ECO:0007744|PDB:8VY7, ECO:0007744|PDB:8VY9, ECO:0007744|PDB:8XQL, ECO:0007744|PDB:8XQN, ECO:0007744|PDB:8XQO, ECO:0007744|PDB:8XQP, ECO:0007744|PDB:8XQR, ECO:0007744|PDB:8XQS, ECO:0007744|PDB:8XQT, ECO:0007744|PDB:8YKY"; TRANSMEM 262..282; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:38600377, ECO:0000269|PubMed:38776963, ECO:0007744|PDB:8VY7, ECO:0007744|PDB:8VY9, ECO:0007744|PDB:8XQL, ECO:0007744|PDB:8XQN, ECO:0007744|PDB:8XQO, ECO:0007744|PDB:8XQP, ECO:0007744|PDB:8XQR, ECO:0007744|PDB:8XQS, ECO:0007744|PDB:8XQT, ECO:0007744|PDB:8YKY
uniprot
proteins