CBX7
entrez
23492
canonical
uniprot
O95931
canonical
ensembl
ENSG00000100307
resolver
ensp
ENSP00000216133
resolver
ensp
ENSP00000384035
resolver
ensp
ENSP00000528835
resolver
enst
ENST00000216133
resolver
enst
ENST00000401405
resolver
genesymbol
CBX7
resolver
hgnc
HGNC:1557
resolver
uniprot
B0QYP2
resolver
uniprot
Q4PNR6
resolver
uniprot
Q86T17
resolver
uniprot_entry
B0QYP2_HUMAN
resolver
uniprot_entry
CBX7_HUMAN
resolver
uniprot_entry
Q4PNR6_HUMAN
resolver
uniprot_sec
Q86T17
resolver
amino_acid_sequence
MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEKEERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSGSPEGVVKAGAPELVDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRRELFLQEPPAPDVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITVTFREAQAAEGFFRDRSGKF
uniprot
proteins
function
FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Promotes histone H3 trimethylation at 'Lys-9' (H3K9me3). Binds to trimethylated lysine residues in histones, and possibly also other proteins. Regulator of cellular lifespan by maintaining the repression of CDKN2A, but not by inducing telomerase activity. {ECO:0000269|PubMed:19636380, ECO:0000269|PubMed:21047797, ECO:0000269|PubMed:21060834, ECO:0000269|PubMed:21282530}.
uniprot
proteins
mass_dalton
28341
uniprot
proteins
mutagenesis
MUTAGEN 31; /note="K->A: Loss of cellular lifespan extension."; /evidence="ECO:0000269|PubMed:14647293"; MUTAGEN 32; /note="W->A: Loss of cellular lifespan extension."; /evidence="ECO:0000269|PubMed:14647293"; MUTAGEN 234; /note="F->D: Loss of interaction with RNF2."; /evidence="ECO:0000269|PubMed:20696397"; MUTAGEN 244; /note="F->D: Reduced interaction with RNF2."; /evidence="ECO:0000269|PubMed:20696397
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
14647293
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19636380
uniprot
proteins
pubmed
19791798
uniprot
proteins
pubmed
20696397
uniprot
proteins
pubmed
21047797
uniprot
proteins
pubmed
21060834
uniprot
proteins
pubmed
21282530
uniprot
proteins
sequence_length
251
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14647293, ECO:0000269|PubMed:21060834, ECO:0000269|PubMed:21282530}.
uniprot
proteins