Ezh2
entrez
14056
canonical
uniprot
Q61188
canonical
ensembl
ENSMUSG00000029687
resolver
ensp
ENSMUSP00000080419
resolver
ensp
ENSMUSP00000090318
resolver
ensp
ENSMUSP00000110265
resolver
ensp
ENSMUSP00000173973
resolver
ensp
ENSMUSP00000173974
resolver
ensp
ENSMUSP00000173975
resolver
ensp
ENSMUSP00000173976
resolver
ensp
ENSMUSP00000173978
resolver
ensp
ENSMUSP00000173979
resolver
ensp
ENSMUSP00000328546
resolver
ensp
ENSMUSP00000328549
resolver
ensp
ENSMUSP00000328553
resolver
ensp
ENSMUSP00000328555
resolver
enst
ENSMUST00000114618
resolver
genesymbol
Ezh2
resolver
genesymbol_syn
Enx1h
resolver
genesymbol_syn
mKIAA4065
resolver
uniprot
F7BU68
resolver
uniprot
Q3TZH6
resolver
uniprot
Q571L5
resolver
uniprot
Q6AXH7
resolver
uniprot
Q99L74
resolver
uniprot
Q9R090
resolver
uniprot_entry
EZH2_MOUSE
resolver
uniprot_entry
F7BU68_MOUSE
resolver
uniprot_entry
Q3TZH6_MOUSE
resolver
uniprot_entry
Q571L5_MOUSE
resolver
uniprot_entry
Q6AXH7_MOUSE
resolver
uniprot_sec
Q99L74
resolver
uniprot_sec
Q9R090
resolver
amino_acid_sequence
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKTMFSSNRQKILERTETLNQEWKQRRIQPVHIMTSVSSLRGTRECSVTSDLDFPAQVIPLKTLNAVASVPIMYSWSPLQQNFMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQYNDDDDDDDGDDPDEREEKQKDLEDNRDDKETCPPRKFPADKIFEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPNNSSRPSTPTISVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKMKPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPVPTEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP
uniprot
proteins
ec_number
2.1.1.356
uniprot
proteins
function
FUNCTION: Catalytic subunit of the PRC2/EED-EZH2 complex, a Polycomb group (PcG) complex that methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:12689588, PubMed:15516932, PubMed:15520282, PubMed:16717091, PubMed:19026780, PubMed:31914400). Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively (PubMed:16717091, PubMed:18086877). Displays a preference for substrates with less methylation, loses activity when progressively more methyl groups are incorporated into H3K27, H3K27me0 > H3K27me1 > H3K27me2 (By similarity). Compared to EZH1-containing complexes, it is more abundant in embryonic stem cells and plays a major role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation (By similarity). The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (By similarity). Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1, CDKN2A and retinoic acid target genes (PubMed:18086877). EZH2 can also methylate non-histone proteins such as the transcription factor GATA4 and the nuclear receptor RORA (By similarity). Regulates the circadian clock via histone methylation at the promoter of the circadian genes (PubMed:16717091). Essential for the CRY1/2-mediated repression of the transcriptional activation of PER1/2 by the CLOCK-BMAL1 heterodimer; involved in the di and trimethylation of 'Lys-27' of histone H3 on PER1/2 promoters which is necessary for the CRY1/2 proteins to inhibit transcription (PubMed:16717091). {ECO:0000250|UniProtKB:Q15910, ECO:0000269|PubMed:12689588, ECO:0000269|PubMed:15516932, ECO:0000269|PubMed:15520282, ECO:0000269|PubMed:16717091, ECO:0000269|PubMed:18086877, ECO:0000269|PubMed:19026780, ECO:0000269|PubMed:31914400}.
uniprot
proteins
mass_dalton
85292
uniprot
proteins
mutagenesis
MUTAGEN 42; /note="F->D: Abrogates interaction with EED."; /evidence="ECO:0000269|PubMed:17937919"; MUTAGEN 45; /note="N->A: Abrogates interaction with EED."; /evidence="ECO:0000269|PubMed:17937919"; MUTAGEN 49; /note="I->E: Abrogates interaction with EED."; /evidence="ECO:0000269|PubMed:17937919"; MUTAGEN 56; /note="L->E: Abrogates interaction with EED."; /evidence="ECO:0000269|PubMed:17937919"; MUTAGEN 67; /note="P->D: Abrogates interaction with EED."; /evidence="ECO:0000269|PubMed:17937919"; MUTAGEN 68; /note="V->E: Abrogates interaction with EED."; /evidence="ECO:0000269|PubMed:17937919
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by AKT1 (By similarity). Phosphorylation by AKT1 reduces methyltransferase activity. Phosphorylation at Thr-345 by CDK1 and CDK2 promotes maintenance of H3K27me3 levels at EZH2-target loci, thus leading to epigenetic gene silencing (By similarity). {ECO:0000250|UniProtKB:Q15910}.; PTM: Sumoylated. {ECO:0000250|UniProtKB:Q15910}.; PTM: Glycosylated: O-GlcNAcylation at Ser-75 by OGT increases stability of EZH2 and facilitates the formation of H3K27me3 by the PRC2/EED-EZH2 complex. {ECO:0000250|UniProtKB:Q15910}.
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
EZ subfamily
uniprot
proteins
protein_family
Histone-lysine methyltransferase family
uniprot
proteins
pubmed
10051331
uniprot
proteins
pubmed
11390661
uniprot
proteins
pubmed
12123576
uniprot
proteins
pubmed
12649488
uniprot
proteins
pubmed
12689588
uniprot
proteins
pubmed
14752160
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15516932
uniprot
proteins
pubmed
15520282
uniprot
proteins
pubmed
15684044
uniprot
proteins
pubmed
16415857
uniprot
proteins
pubmed
16717091
uniprot
proteins
pubmed
17259173
uniprot
proteins
pubmed
17344414
uniprot
proteins
pubmed
17937919
uniprot
proteins
pubmed
18086877
uniprot
proteins
pubmed
18281287
uniprot
proteins
pubmed
19026780
uniprot
proteins
pubmed
19026781
uniprot
proteins
pubmed
20144788
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23970558
uniprot
proteins
pubmed
24074865
uniprot
proteins
pubmed
31451685
uniprot
proteins
pubmed
31914400
uniprot
proteins
pubmed
8861097
uniprot
proteins
pubmed
9742080
uniprot
proteins
sequence_length
746
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12123576}. Chromosome. Note=Localizes to the inactive X chromosome in trophoblast stem cells. {ECO:0000269|PubMed:12123576}.
uniprot
proteins