CPE
entrez
1363
canonical
uniprot
P16870
canonical
ensembl
ENSG00000109472
resolver
ensp
ENSP00000386104
resolver
genesymbol
CPE
resolver
hgnc
HGNC:2303
resolver
uniprot
A0A384N679
resolver
uniprot
A8K4N1
resolver
uniprot
B3KR42
resolver
uniprot
B4DFN4
resolver
uniprot
D3DP33
resolver
uniprot
Q9UIU9
resolver
uniprot_entry
A0A384N679_HUMAN
resolver
uniprot_entry
CBPE_HUMAN
resolver
uniprot_sec
A8K4N1
resolver
uniprot_sec
B3KR42
resolver
uniprot_sec
B4DFN4
resolver
uniprot_sec
D3DP33
resolver
uniprot_sec
Q9UIU9
resolver
amino_acid_sequence
MAGRGGSALLALCGALAACGWLLGAEAQEPGAPAAGMRRRRRLQQEDGISFEYHRYPELREALVSVWLQCTAISRIYTVGRSFEGRELLVIELSDNPGVHEPGEPEFKYIGNMHGNEAVGRELLIFLAQYLCNEYQKGNETIVNLIHSTRIHIMPSLNPDGFEKAASQPGELKDWFVGRSNAQGIDLNRNFPDLDRIVYVNEKEGGPNNHLLKNMKKIVDQNTKLAPETKAVIHWIMDIPFVLSANLHGGDLVANYPYDETRSGSAHEYSSSPDDAIFQSLARAYSSFNPAMSDPNRPPCRKNDDDSSFVDGTTNGGAWYSVPGGMQDFNYLSSNCFEITVELSCEKFPPEETLKTYWEDNKNSLISYLEQIHRGVKGFVRDLQGNPIANATISVEGIDHDVTSAKDGDYWRLLIPGNYKLTASAPGYLAITKKVAVPYSPAAGVDFELESFSERKEEEKEELMEWWKMMSETLNF
uniprot
proteins
disease_involvement
DISEASE: BDV syndrome (BDVS) [MIM:619326]: An autosomal recessive disorder characterized by obesity, intellectual disability, and hypogonadotropic hypogonadism. Additional variable features include central hypothyroidism, hypotonia, and developmental delay. {ECO:0000269|PubMed:32936766, ECO:0000269|PubMed:34383079}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.4.17.10
uniprot
proteins
function
FUNCTION: Sorting receptor that directs prohormones to the regulated secretory pathway. Also acts as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage. {ECO:0000250|UniProtKB:Q00493}.
uniprot
proteins
mass_dalton
53151
uniprot
proteins
protein_family
Peptidase M14 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
21285511
uniprot
proteins
pubmed
2334405
uniprot
proteins
pubmed
30882370
uniprot
proteins
pubmed
32936766
uniprot
proteins
pubmed
34383079
uniprot
proteins
pubmed
9662053
uniprot
proteins
sequence_length
476
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:Q00493}. Cytoplasmic vesicle, secretory vesicle membrane {ECO:0000250|UniProtKB:P15087}; Peripheral membrane protein {ECO:0000250|UniProtKB:P15087}. Secreted {ECO:0000250|UniProtKB:P15087}. Note=Associated with the secretory granule membrane through direct binding to lipid rafts in intragranular conditions. {ECO:0000250|UniProtKB:Q00493}.
uniprot
proteins