Dnajc2
entrez
116456
canonical
uniprot
Q7TQ20
canonical
ensembl
ENSRNOG00000012392
resolver
ensembl
ENSRNOG00055021529
resolver
ensembl
ENSRNOG00060028038
resolver
ensembl
ENSRNOG00065017878
resolver
ensp
ENSRNOP00000016909
resolver
genesymbol
Dnajc2
resolver
genesymbol_syn
Mida1
resolver
genesymbol_syn
Zrf1
resolver
uniprot
Q5HZY5
resolver
uniprot
Q7TQ18
resolver
uniprot
Q9WVG4
resolver
uniprot_entry
DNJC2_RAT
resolver
uniprot_sec
Q5HZY5
resolver
uniprot_sec
Q7TQ18
resolver
uniprot_sec
Q9WVG4
resolver
amino_acid_sequence
MLLLPSAAEGQGTAITHALTSASAVCQVEPVGRWFEAFVKRRNRNASTSFQELEDKKELSEESEDEELQLEEFPMLKTLDPKDWKNQDHYAVLGLGHVRYKATQRQIKAAHKTMVLKHHPDKRKAAGEPIKEGDNDYFTCITKAYEMLSDPVKRRAFNSVDPTFDNSVPSKSEAKENFFQVFSPVFERNSRWSNKKNVPKLGDMNSSFEDVDAFYSFWYNFDSWREFSYLDEEEKEKAECRDERKWIEKQNRATRAQRKKEEMNRIRTLVDNAYSCDPRIKKFKEEGKAKKEAEKRAKAEARRKEQEAKEKQRQAELEAVRLAKEKEEEEVRQQALLAKKEKEIQKKAIKKERQKLRNSCKNWNHFSDNEADRVKMMEEVEKLCDRLELASLQCLNEILASSTREVGKAALEKQIEEVNELMRKEKEEADARMRQASKNAEKSTGGSGSGSKNWSEDDLQLLIKAVNLFPAGTNSRWEVIANYMNIHSSSGVKRTAKDVIGKAKSLQKLDPHQKDDINKKAFDKFKKEHGVAPQADSAAPSERFEGPCIDSIPWTTEEQKLLEQALKTYPVNTPERWEKIAEAVPGRTKKDCMRRYKELVEMVKAKKAAQEQVLNASRARK
uniprot
proteins
function
FUNCTION: Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. {ECO:0000250|UniProtKB:Q99543}.
uniprot
proteins
mass_dalton
71769
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in M (mitotic) phase. {ECO:0000250|UniProtKB:Q99543}.
uniprot
proteins
pubmed
11289140
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
621
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q99543}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q99543}.
uniprot
proteins