SGK3
entrez
23678
canonical
uniprot
Q96BR1
canonical
ensembl
ENSG00000104205
resolver
ensembl
ENSG00000288602
resolver
ensp
ENSP00000379842
resolver
ensp
ENSP00000430463
resolver
ensp
ENSP00000430691
resolver
genesymbol
SGK3
resolver
genesymbol_syn
CISK
resolver
genesymbol_syn
SGKL
resolver
hgnc
HGNC:10812
resolver
uniprot
A8K5W3
resolver
uniprot
B3KQC2
resolver
uniprot
Q53EW6
resolver
uniprot
Q9P1Q7
resolver
uniprot
Q9UKG5
resolver
uniprot_entry
Q53EW6_HUMAN
resolver
uniprot_entry
SGK3_HUMAN
resolver
uniprot_sec
A8K5W3
resolver
uniprot_sec
B3KQC2
resolver
uniprot_sec
Q9P1Q7
resolver
uniprot_sec
Q9UKG5
resolver
activity_regulation
ACTIVITY REGULATION: Two specific sites, one in the kinase domain (Thr-320) and the other in the C-terminal regulatory region (Ser-486), need to be phosphorylated for its full activation.
uniprot
proteins
amino_acid_sequence
MQRDHTMDYKESCPSVSIPSSDEHREKKKRFTVYKVLVSVGRSEWFVFRRYAEFDKLYNTLKKQFPAMALKIPAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYPELYNHPDVRAFLQMDSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKRKLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGGELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEGIAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAEMYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKEDFLEIQNHPFFESLSWADLVQKKIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPPSEDLFL
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, proliferation, survival and migration. Up-regulates Na(+) channels: SCNN1A/ENAC and SCN5A, K(+) channels: KCNA3/KV1.3, KCNE1, KCNQ1 and KCNH2/HERG, epithelial Ca(2+) channels: TRPV5 and TRPV6, chloride channel: BSND, creatine transporter: SLC6A8, Na(+)/dicarboxylate cotransporter: SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter: SLC34A2/NAPI-2B, amino acid transporters: SLC1A5/ASCT2 and SLC6A19, glutamate transporters: SLC1A3/EAAT1, SLC1A6/EAAT4 and SLC1A7/EAAT5, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na(+)/H(+) exchanger: SLC9A3/NHE3, and the Na(+)/K(+) ATPase. Plays a role in the regulation of renal tubular phosphate transport and bone density. Phosphorylates NEDD4L and GSK3B. Positively regulates ER transcription activity through phosphorylation of FLII. Negatively regulates the function of ITCH/AIP4 via its phosphorylation and thereby prevents CXCR4 from being efficiently sorted to lysosomes. {ECO:0000269|PubMed:12054501, ECO:0000269|PubMed:12397388, ECO:0000269|PubMed:12590200, ECO:0000269|PubMed:12632189, ECO:0000269|PubMed:12634932, ECO:0000269|PubMed:12650886, ECO:0000269|PubMed:12911626, ECO:0000269|PubMed:14706641, ECO:0000269|PubMed:15040001, ECO:0000269|PubMed:15044175, ECO:0000269|PubMed:15319523, ECO:0000269|PubMed:15496163, ECO:0000269|PubMed:15737648, ECO:0000269|PubMed:15845389, ECO:0000269|PubMed:16036218, ECO:0000269|PubMed:16888620, ECO:0000269|PubMed:17167223, ECO:0000269|PubMed:18005662, ECO:0000269|PubMed:19293151, ECO:0000269|PubMed:20511718, ECO:0000269|PubMed:21865597}.
uniprot
proteins
mass_dalton
57108
uniprot
proteins
mutagenesis
MUTAGEN 90; /note="R->A: Partially localized to the membrane."; /evidence="ECO:0000269|PubMed:16790420"; MUTAGEN 191; /note="K->M: Abolishes activity."; /evidence="ECO:0000269|PubMed:16790420"; MUTAGEN 486; /note="S->D: Increased activation."; /evidence="ECO:0000269|PubMed:10548550
uniprot
proteins
post_translational_modification
PTM: Activated by phosphorylation on Ser-486 by an unknown kinase (may be mTORC2 but not confirmed), transforming it into a substrate for PDPK1 which then phosphorylates it on Thr-320. {ECO:0000269|PubMed:10548550, ECO:0000269|PubMed:14604990, ECO:0000269|PubMed:16790420, ECO:0000269|PubMed:16888620}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10548550
uniprot
proteins
pubmed
10585774
uniprot
proteins
pubmed
12054501
uniprot
proteins
pubmed
12397388
uniprot
proteins
pubmed
12590200
uniprot
proteins
pubmed
12632189
uniprot
proteins
pubmed
12634932
uniprot
proteins
pubmed
12650886
uniprot
proteins
pubmed
12911626
uniprot
proteins
pubmed
14604990
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14706641
uniprot
proteins
pubmed
15040001
uniprot
proteins
pubmed
15044175
uniprot
proteins
pubmed
15319523
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15496163
uniprot
proteins
pubmed
15737648
uniprot
proteins
pubmed
15845389
uniprot
proteins
pubmed
16036218
uniprot
proteins
pubmed
16460280
uniprot
proteins
pubmed
16790420
uniprot
proteins
pubmed
16888620
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17167223
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18005662
uniprot
proteins
pubmed
19293151
uniprot
proteins
pubmed
20511718
uniprot
proteins
pubmed
20919962
uniprot
proteins
pubmed
21084382
uniprot
proteins
pubmed
21865597
uniprot
proteins
sequence_length
496
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000250}. Early endosome. Recycling endosome. Note=Endosomal localization is a prerequisite for complete kinase activity. It is essential for its colocalization with the kinase responsible for phosphorylating Ser-486 thus allowing PDPK1 phosphorylation of Thr-320 resulting in complete activation of SGK3. Localized in vesicle-like structures and in the early endosome. Colocalizes with SLC9A3/NHE3 in the recycling endosomes.
uniprot
proteins