Kctd13
entrez
233877
canonical
uniprot
Q8BGV7
canonical
ensembl
ENSMUSG00000030685
resolver
ensp
ENSMUSP00000032924
resolver
enst
ENSMUST00000032924
resolver
genesymbol
Kctd13
resolver
genesymbol_syn
Poldip1
resolver
uniprot
Q6AXE9
resolver
uniprot_entry
BACD1_MOUSE
resolver
uniprot_sec
Q6AXE9
resolver
amino_acid_sequence
MSAEASGPAPAAAECLESPSPSSVEPGSPSYSLKPLTPNSKYVKLNVGGSLHYTTLRTLTGQDTMLKAMFSGRVEVLTDAGGWVLIDRSGRHFGTILNYLRDGSVPLPESARELGELLGEARYYLVQGLIEDCQLALQQKREKLSPLCLIPTVTSPREEQQLLASTSKPVVKLLHNRSNNKYSYTSTSDDNLLKNIELFDKLALRFHGRLLFLKDVLGDEICCWSFYGQGRKIAEVCCTSIVYATEKKQTKVEFPEARIFEETLNILIYENSRGPDLALLEATGGAAGGGGAGRGDDEENREHRVRRIHVRRHITHDERPHGQQIVFKD
uniprot
proteins
function
FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission (PubMed:29088697). The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and promoting synaptic transmission (PubMed:29088697). Mediates also the ubiquitination and degradation of GluN1/GRIN1 to regulate excitatory synaptic transmission and seizure susceptibility (PubMed:37142655). {ECO:0000269|PubMed:29088697, ECO:0000269|PubMed:37142655}.
uniprot
proteins
mass_dalton
36442
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q8WZ19}.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex, at least composed of CUL3, KCTD10/BACURD3 and RBX1, leading to proteasomal degradation. {ECO:0000269|PubMed:38489388}.
uniprot
proteins
protein_family
BACURD family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
22596160
uniprot
proteins
pubmed
29088697
uniprot
proteins
pubmed
37142655
uniprot
proteins
pubmed
38489388
uniprot
proteins
sequence_length
329
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:37142655}. Cytoplasm {ECO:0000269|PubMed:37142655}.
uniprot
proteins