OR2AT4
entrez
341152
canonical
uniprot
A6NND4
canonical
ensembl
ENSG00000171561
resolver
ensp
ENSP00000304846
resolver
ensp
ENSP00000493299
resolver
ensp
ENSP00000493318
resolver
ensp
ENSP00000493416
resolver
ensp
ENSP00000493460
resolver
enst
ENST00000305159
resolver
enst
ENST00000641504
resolver
enst
ENST00000641541
resolver
enst
ENST00000641593
resolver
enst
ENST00000641931
resolver
genesymbol
OR2AT4
resolver
hgnc
HGNC:19620
resolver
uniprot
B9EGZ8
resolver
uniprot_entry
O2AT4_HUMAN
resolver
uniprot_sec
B9EGZ8
resolver
amino_acid_sequence
MDATACNESVDGSPVFYLLGIPSLPETFFLPVFFIFLLFYLLILMGNALILVAVVAEPSLHKPMYFFLINLSTLDILFTTTTVPKMLSLFLLGDRFLSFSSCLLQMYLFQSFTCSEAFILVVMAYDRYVAICHPLHYPVLMNPQTNATLAASAWLTALLLPIPAVVRTSQMAYNSIAYIYHCFCDHLAVVQASCSDTTPQTLMGFCIAMVVSFLPLLLVLLSYVHILASVLRISSLEGRAKAFSTCSSHLLVVGTYYSSIAIAYVAYRADLPLDFHIMGNVVYAILTPILNPLIYTLRNRDVKAAITKIMSQDPGCDRSI
uniprot
proteins
function
FUNCTION: Olfactory receptor (PubMed:24999593, PubMed:30228264). Activated by the synthetic sandalwood odorant sandalore (PubMed:24999593, PubMed:30228264). Endogenous ligand is unknown (Probable). The activity of this receptor is probably mediated by G proteins which induce elevation of intracellular Ca(2+), a cAMP-dependent pathway and phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and p38 MAPKs (PubMed:24999593, PubMed:30228264). Activation of OR2AT4 induces proliferation, migration, and re-epithelialization during wound-healing processes of keratinocytes (PubMed:24999593). Stimulation of OR2AT4 by sandalore promotes hair growth by decreasing apoptosis and increasing production of the anagen-prolonging growth factor IGF1 as well as other pathways involving various kinases (PubMed:30228264). {ECO:0000269|PubMed:24999593, ECO:0000269|PubMed:30228264, ECO:0000305}.
uniprot
proteins
mass_dalton
35503
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
14983052
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
24999593
uniprot
proteins
pubmed
30228264
uniprot
proteins
sequence_length
320
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24999593}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..52; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 63..83; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 103..123; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 146..166; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 201..221; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 246..266; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 277..297; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins