PDGFD
entrez
80310
canonical
uniprot
Q9GZP0
canonical
ensembl
ENSG00000170962
resolver
ensp
ENSP00000302193
resolver
ensp
ENSP00000376865
resolver
genesymbol
PDGFD
resolver
genesymbol_syn
IEGF
resolver
genesymbol_syn
SCDGFB
resolver
hgnc
HGNC:30620
resolver
uniprot
A8K9T6
resolver
uniprot
Q9BWV5
resolver
uniprot_entry
PDGFD_HUMAN
resolver
uniprot_sec
A8K9T6
resolver
uniprot_sec
Q9BWV5
resolver
amino_acid_sequence
MHRLIFVYTLICANFCSCRDTSATPQSASIKALRNANLRRDESNHLTDLYRRDETIQVKGNGYVQSPRFPNSYPRNLLLTWRLHSQENTRIQLVFDNQFGLEEAENDICRYDFVEVEDISETSTIIRGRWCGHKEVPPRIKSRTNQIKITFKSDDYFVAKPGFKIYYSLLEDFQPAAASETNWESVTSSISGVSYNSPSVTDPTLIADALDKKIAEFDTVEDLLKYFNPESWQEDLENMYLDTPRYRGRSYHDRKSKVDLDRLNDDAKRYSCTPRNYSVNIREELKLANVVFFPRCLLVQRCGGNCGCGTVNWRSCTCNSGKTVKKYHEVLQFEPGHIKRRGRAKTMALVDIQLDHHERCDCICSSRPPR
uniprot
proteins
function
FUNCTION: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity). {ECO:0000250, ECO:0000269|PubMed:11331881, ECO:0000269|PubMed:15271796}.
uniprot
proteins
mass_dalton
42848
uniprot
proteins
mutagenesis
MUTAGEN 247; /note="R->A: Abolishes cleavage into active form; when associated with A-249."; /evidence="ECO:0000269|PubMed:15988036"; MUTAGEN 249; /note="R->A: Abolishes cleavage into active form; when associated with A-247."; /evidence="ECO:0000269|PubMed:15988036
uniprot
proteins
post_translational_modification
PTM: Activated by proteolytic cleavage. Proteolytic removal of the N-terminal CUB domain releasing the core domain is necessary for unmasking the receptor-binding epitopes of the core domain. Cleavage after Arg-247 or Arg-249 by urokinase plasminogen activator gives rise to the active form.
uniprot
proteins
protein_family
PDGF/VEGF growth factor family
uniprot
proteins
pubmed
11162582
uniprot
proteins
pubmed
11331881
uniprot
proteins
pubmed
11331882
uniprot
proteins
pubmed
11342471
uniprot
proteins
pubmed
11980634
uniprot
proteins
pubmed
12107412
uniprot
proteins
pubmed
12427128
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14514732
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15271796
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15988036
uniprot
proteins
pubmed
16279938
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
20434526
uniprot
proteins
sequence_length
370
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11331882}. Note=Released by platelets upon wounding.
uniprot
proteins