Sars1
entrez
266975
canonical
uniprot
Q6P799
canonical
ensembl
ENSRNOG00000020255
resolver
ensembl
ENSRNOG00055020996
resolver
ensembl
ENSRNOG00060027643
resolver
ensembl
ENSRNOG00065021844
resolver
ensp
ENSRNOP00000038448
resolver
ensp
ENSRNOP00000071040
resolver
ensp
ENSRNOP00055029134
resolver
ensp
ENSRNOP00060039954
resolver
ensp
ENSRNOP00065029986
resolver
enst
ENSRNOT00000033015
resolver
enst
ENSRNOT00000091896
resolver
enst
ENSRNOT00055035877
resolver
enst
ENSRNOT00060048010
resolver
enst
ENSRNOT00065037178
resolver
genesymbol
Sars1
resolver
genesymbol_syn
Sars
resolver
uniprot
A0A0G2JZG7
resolver
uniprot
Q8CIQ8
resolver
uniprot_entry
A0A0G2JZG7_RAT
resolver
uniprot_entry
SYSC_RAT
resolver
uniprot_sec
Q8CIQ8
resolver
amino_acid_sequence
MVLDLDLFRVDKGGDPALIRETQEKRFKDPGLVDQLVKADSEWRRCRFRADNLNKLKNLCSKTIGEKMKKKEPVGEDESIPEDVLNFDDLTADTLAALKVSQIKKVRLLVDEAIQKCDGERVKLEAERFENLREIGNLLHPSVPISNDEDADNKVERIWGDCTVRKKYSHVDLVVMVDGFEGEKGAVVAGSRGYFLKGVLVFLEQALIQYALRTLGSRGYTPIYTPFFMRKEVMQEVAQLSQFDEELYKVIGKGSEKSDDSSYDEKYLIATSEQPIAALHRDEWLRPEDLPIKYAGFSTCFRQEVGSHGRDTRGIFRVHQFEKIEQFVYSSPHDNKSWEMFDEMITTAEEFYQSLGIPYHIVNIVSGSLNHAASKKLDLEAWFPGSGAFRELVSCSNCTDYQARRLRIRYGQTKKMMDKVEFVHMLNATMCATTRTICAILENYQTEKGIVVPEKLREFMPPGLQELIPFVKPAPIDQEPSKKQKKQHEGSKKKAKEVTLENQLQNMEVTEA
uniprot
proteins
ec_number
6.1.1.11
uniprot
proteins
function
FUNCTION: Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA. {ECO:0000250|UniProtKB:P49591}.
uniprot
proteins
mass_dalton
58588
uniprot
proteins
pathway_participation
PATHWAY: Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.
uniprot
proteins
protein_family
Class-II aminoacyl-tRNA synthetase family
uniprot
proteins
protein_family
Type-1 seryl-tRNA synthetase subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
512
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P49591}. Nucleus {ECO:0000250|UniProtKB:P49591}. Note=Predominantly cytoplasmic, but a minor proportion is also found in the nucleus. {ECO:0000250|UniProtKB:P49591}.
uniprot
proteins