Nr1i3
entrez
12355
canonical
uniprot
O35627
canonical
ensembl
ENSMUSG00000005677
resolver
ensp
ENSMUSP00000005820
resolver
ensp
ENSMUSP00000074915
resolver
ensp
ENSMUSP00000106960
resolver
ensp
ENSMUSP00000361724
resolver
enst
ENSMUST00000111328
resolver
genesymbol
Nr1i3
resolver
genesymbol_syn
Car
resolver
uniprot
F6W8B9
resolver
uniprot
O35628
resolver
uniprot
Q3V008
resolver
uniprot
Q5FW96
resolver
uniprot_entry
F6W8B9_MOUSE
resolver
uniprot_entry
NR1I3_MOUSE
resolver
uniprot_entry
Q5FW96_MOUSE
resolver
uniprot_sec
O35628
resolver
uniprot_sec
Q3V008
resolver
amino_acid_sequence
MTAMLTLETMASEEEYGPRNCVVCGDRATGYHFHALTCEGCKGFFRRTVSKTIGPICPFAGRCEVSKAQRRHCPACRLQKCLNVGMRKDMILSAEALALRRARQAQRRAEKASLQLNQQQKELVQILLGAHTRHVGPMFDQFVQFKPPAYLFMHHRPFQPRGPVLPLLTHFADINTFMVQQIIKFTKDLPLFRSLTMEDQISLLKGAAVEILHISLNTTFCLQTENFFCGPLCYKMEDAVHAGFQYEFLESILHFHKNLKGLHLQEPEYVLMAATALFSPDRPGVTQREEIDQLQEEMALILNNHIMEQQSRLQSRFLYAKLMGLLADLRSINNAYSYELQRLEELSAMTPLLGEICS
uniprot
proteins
function
FUNCTION: Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element (By similarity). {ECO:0000250, ECO:0000269|PubMed:10462436}.
uniprot
proteins
mass_dalton
40913
uniprot
proteins
mutagenesis
MUTAGEN 171; /note="F->W: Diminished binding of coactivator NCOA2 in the presence of TCPOBOP."; /evidence="ECO:0000269|PubMed:15610733"; MUTAGEN 175; /note="N->F: Diminished binding of coactivator NCOA2 in the presence of TCPOBOP."; /evidence="ECO:0000269|PubMed:15610733"; MUTAGEN 216; /note="L->F: Diminished binding of coactivator NCOA2 in the presence of TCPOBOP."; /evidence="ECO:0000269|PubMed:15610733"; MUTAGEN 227; /note="F->W: Diminished binding of coactivator NCOA2 in the presence of TCPOBOP."; /evidence="ECO:0000269|PubMed:15610733"; MUTAGEN 234; /note="Y->A: No effect on binding of coactivator NCOA2 in the presence of TCPOBOP."; /evidence="ECO:0000269|PubMed:15610733"; MUTAGEN 244; /note="F->A: Diminished binding of coactivator NCOA2 in the presence of TCPOBOP."; /evidence="ECO:0000269|PubMed:15610733"; MUTAGEN 336; /note="Y->A: Diminished binding of coactivator NCOA2 in the presence of TCPOBOP."; /evidence="ECO:0000269|PubMed:15610733"; MUTAGEN 346; /note="L->F: Dramatic increase in binding NCOA2. Little effect on binding of coactivator NCOA2 in the presence of TCPOBOP."; /evidence="ECO:0000269|PubMed:15610733
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Thr-48 by PKC, dephosphorylation of Thr-48 is required for nuclear translocation and activation. {ECO:0000250}.
uniprot
proteins
protein_family
NR1 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
10462436
uniprot
proteins
pubmed
14573755
uniprot
proteins
pubmed
15610733
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17904126
uniprot
proteins
pubmed
28751364
uniprot
proteins
pubmed
8603043
uniprot
proteins
pubmed
9295294
uniprot
proteins
sequence_length
358
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Recruited to the cytoplasm by DNAJC7.
uniprot
proteins