Hs2st1
entrez
23908
canonical
uniprot
Q8R3H7
canonical
ensembl
ENSMUSG00000040151
resolver
ensp
ENSMUSP00000043066
resolver
ensp
ENSMUSP00000191426
resolver
enst
ENSMUST00000043325
resolver
genesymbol
Hs2st1
resolver
genesymbol_syn
Hs2st
resolver
uniprot
O88464
resolver
uniprot
Q3TNP7
resolver
uniprot
Q9JLK2
resolver
uniprot_entry
HS2ST_MOUSE
resolver
uniprot_sec
O88464
resolver
uniprot_sec
Q3TNP7
resolver
uniprot_sec
Q9JLK2
resolver
amino_acid_sequence
MGLLRIMMPPKLQLLAVVAFAVAMLFLENQIQKLEESRAKLERAIARHEVREIEQRHTMDGPRQDATLDEEEDIIIIYNRVPKTASTSFTNIAYDLCAKNRYHVLHINTTKNNPVMSLQDQVRFVKNITTWNEMKPGFYHGHISYLDFAKFGVKKKPIYINVIRDPIERLVSYYYFLRFGDDYRPGLRRRKQGDKKTFDECVAEGGSDCAPEKLWLQIPFFCGHSSECWNVGSRWAMDQAKSNLINEYFLVGVTEELEDFIMLLEAALPRFFRGATDLYRTGKKSHLRKTTEKKLPTKQTIAKLQQSDIWKMENEFYEFALEQFQFIRAHAVREKDGDLYILAQNFFYEKIYPKSN
uniprot
proteins
ec_number
2.8.2.-
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of a sulfo group from 3'-phospho-5'-adenylyl sulfate (PAPS) to the 2-OH position of iduronic acid (IdoA) or glucuronic acid (GlcA) within the heparan sulfate (HS) chain and participates in HS biosynthesis (PubMed:11331020, PubMed:11457822). Required for metanephric development of kidney formation, suggesting that 2-O-sulfation within HS is essential for signaling between ureteric bud and metanephric mesenchyme (PubMed:9637690). {ECO:0000269|PubMed:11331020, ECO:0000269|PubMed:11457822, ECO:0000269|PubMed:9637690}.
uniprot
proteins
mass_dalton
41813
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:O08889}.
uniprot
proteins
protein_family
Sulfotransferase 3 family
uniprot
proteins
pubmed
10677367
uniprot
proteins
pubmed
11331020
uniprot
proteins
pubmed
11457822
uniprot
proteins
pubmed
11687650
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9637690
uniprot
proteins
sequence_length
356
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:11687650}; Single-pass type II membrane protein {ECO:0000269|PubMed:11687650}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..28; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins