Ophn1
entrez
312108
canonical
uniprot
P0CAX5
canonical
ensembl
ENSRNOG00000026573
resolver
ensembl
ENSRNOG00055030994
resolver
ensembl
ENSRNOG00060023850
resolver
ensembl
ENSRNOG00065016392
resolver
ensp
ENSRNOP00000035867
resolver
ensp
ENSRNOP00055044491
resolver
ensp
ENSRNOP00060034280
resolver
ensp
ENSRNOP00065021437
resolver
enst
ENSRNOT00000034772
resolver
enst
ENSRNOT00055053773
resolver
enst
ENSRNOT00060041377
resolver
enst
ENSRNOT00065027303
resolver
genesymbol
Ophn1
resolver
uniprot_entry
OPHN1_RAT
resolver
amino_acid_sequence
MGHPPLEFSDCYLDSPDFRERLKCYEQELERTNKFIKDVIKDGSALISAMRSYSSAVQKFSQTLQSFQFDFIGDTLTDDEINIAESFKEFAELLNEVENERMMMVQNASDLLIKPLETFRKEQIGFTKERKKKFEKDGERFYSLLDRHLHLSSKKKESQLLEADLQVDKERHNFFESSLDYVYQIQEVQESKKFNIVEPVLAFLHSLFISNSLTVELTQDFLPYKQQLQLSLQNTRNHFSSTREEMEELKKRMKEAPQTCKLPGQPTIEGYLYTQEKWALGISWVKYYCRYEKETRTLTMTPTEQKPGAKQGPVDLTLKYCVRRKTESIDKRFCFDIEANERTGTITLQAPSEANRRLWMEAMDGKEPIYHSPITKQEEMELNEVGFKFVRKCINFIETKGIKTEGLYRTVGSNIQVQKLLNAFFDPKCPGDVDFYNSDWDIKTITSSLKFYLRNLSEPVMTYKLHKELVSAAKSDNLDYRLGAIHSLVYKLPEKNREMLELLIKHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMMNIKFQNIVVEILIEHFGKIYLGPPEDSQVPPVPPPRVTARRHKPITISKRLLREKAVFYTPSLDDVEDEIHHPTPNGTIASNLDPPKQLQHLKLPMQKSGEMDPGRKSPSRPVSDCQTEPCLEADMGKLVYRLQDGGTKAIPKASNGPVPGSGHTKTSSFHIKRPAPRPIVHHKEGDTDCFSKVRPPGEKQTIIRPPVRPPDPPCRSSTSQKPESKPETVSSNAEEIPSSVVASRTRFFETASRKTGSSQGKLPGDES
uniprot
proteins
function
FUNCTION: Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function, in hippocampal neurons. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at pre-synaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation. {ECO:0000269|PubMed:15034583, ECO:0000269|PubMed:19481455, ECO:0000269|PubMed:19487570}.
uniprot
proteins
mass_dalton
91839
uniprot
proteins
pubmed
15026118
uniprot
proteins
pubmed
15034583
uniprot
proteins
pubmed
19481455
uniprot
proteins
pubmed
19487570
uniprot
proteins
pubmed
21874017
uniprot
proteins
sequence_length
802
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynapse {ECO:0000269|PubMed:15034583, ECO:0000269|PubMed:19487570}. Presynapse {ECO:0000269|PubMed:15034583, ECO:0000305|PubMed:19481455}. Cell projection, axon {ECO:0000269|PubMed:15034583}. Cell projection, dendritic spine {ECO:0000269|PubMed:15034583}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q99J31}. Cytoplasm {ECO:0000250|UniProtKB:Q99J31}.
uniprot
proteins