Prdx3
entrez
64371
canonical
uniprot
Q9Z0V6
canonical
ensembl
ENSRNOG00000010958
resolver
ensp
ENSRNOP00000015186
resolver
enst
ENSRNOT00000015186
resolver
genesymbol
Prdx3
resolver
uniprot
G3V7I0
resolver
uniprot
Q6P9W3
resolver
uniprot_entry
G3V7I0_RAT
resolver
uniprot_entry
PRDX3_RAT
resolver
uniprot_sec
Q6P9W3
resolver
amino_acid_sequence
MAAAAGRLLWSSVARPASTIFRSISASTVLRPVASRRTCLTDMLWSACPQAKFAFSTSSSFHTPAVTQHAPHFKGTAVVNGEFKELSLDDFKGKYLVLFFYPLDFTFVCPTEIVAFSDKANEFHDVNCEVVAVSVDSHFSHLAWINTPRKNGGLGHMNITLLSDLTKQISRDYGVLLESAGIALRGLFIIDPNGVIKHLSVNDLPVGRSVEEPLRLVKAFQFVETHGEVCPANWTPESPTIKPSPTASKEYFEKVHQ
uniprot
proteins
ec_number
1.11.1.24
uniprot
proteins
function
FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (By similarity). Required for the maintenance of physical strength (By similarity). {ECO:0000250|UniProtKB:P20108, ECO:0000250|UniProtKB:P30048}.
uniprot
proteins
mass_dalton
28295
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by LRRK2; phosphorylation reduces perodixase activity. {ECO:0000250|UniProtKB:P30048}.; PTM: The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond. {ECO:0000250|UniProtKB:P30048}.; PTM: S-palmitoylated. {ECO:0000250|UniProtKB:P20108}.
uniprot
proteins
protein_family
AhpC/Prx1 subfamily
uniprot
proteins
protein_family
Peroxiredoxin family
uniprot
proteins
pubmed
10025941
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
257
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P35705}. Cytoplasm {ECO:0000250|UniProtKB:P30048}. Early endosome {ECO:0000250|UniProtKB:P30048}. Note=Localizes to early endosomes in a RPS6KC1-dependent manner. {ECO:0000250|UniProtKB:P30048}.
uniprot
proteins