Klk8
entrez
259277
canonical
uniprot
Q61955
canonical
ensembl
ENSMUSG00000064023
resolver
ensp
ENSMUSP00000082588
resolver
ensp
ENSMUSP00000145580
resolver
enst
ENSMUST00000085461
resolver
genesymbol
Klk8
resolver
genesymbol_syn
Nrpn
resolver
genesymbol_syn
Prss19
resolver
uniprot
A0A0B6VRH9
resolver
uniprot
Q8K5D7
resolver
uniprot_entry
A0A0B6VRH9_MOUSE
resolver
uniprot_entry
KLK8_MOUSE
resolver
uniprot_sec
Q8K5D7
resolver
activity_regulation
ACTIVITY REGULATION: Strongly inhibited by diisopropyl fluorophosphate, leupeptin and (4-amidinophenyl)methanesulfonyl 1-fluoride. {ECO:0000269|PubMed:9556608}.
uniprot
proteins
amino_acid_sequence
MGRPPPCAIQPWILLLLFMGAWAGLTRAQGSKILEGRECIPHSQPWQAALFQGERLICGGVLVGDRWVLTAAHCKKQKYSVRLGDHSLQSRDQPEQEIQVAQSIQHPCYNNSNPEDHSHDIMLIRLQNSANLGDKVKPVQLANLCPKVGQKCIISGWGTVTSPQENFPNTLNCAEVKIYSQNKCERAYPGKITEGMVCAGSSNGADTCQGDSGGPLVCDGMLQGITSWGSDPCGKPEKPGVYTKICRYTTWIKKTMDNRD
uniprot
proteins
ec_number
3.4.21.118
uniprot
proteins
function
FUNCTION: Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer-collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury. {ECO:0000269|PubMed:10762375, ECO:0000269|PubMed:11880192, ECO:0000269|PubMed:12944500, ECO:0000269|PubMed:16308352, ECO:0000269|PubMed:16537644, ECO:0000269|PubMed:17182622, ECO:0000269|PubMed:17629414, ECO:0000269|PubMed:9556608}.
uniprot
proteins
mass_dalton
28524
uniprot
proteins
protein_family
Kallikrein subfamily
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
10196465
uniprot
proteins
pubmed
10421059
uniprot
proteins
pubmed
10762375
uniprot
proteins
pubmed
10773678
uniprot
proteins
pubmed
11273653
uniprot
proteins
pubmed
11274744
uniprot
proteins
pubmed
11549709
uniprot
proteins
pubmed
11880192
uniprot
proteins
pubmed
12354676
uniprot
proteins
pubmed
12944500
uniprot
proteins
pubmed
14616360
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16308352
uniprot
proteins
pubmed
16537644
uniprot
proteins
pubmed
17182622
uniprot
proteins
pubmed
17629414
uniprot
proteins
pubmed
17761692
uniprot
proteins
pubmed
7623137
uniprot
proteins
pubmed
8602273
uniprot
proteins
pubmed
8864305
uniprot
proteins
pubmed
9374276
uniprot
proteins
pubmed
9556608
uniprot
proteins
pubmed
9620300
uniprot
proteins
pubmed
9749739
uniprot
proteins
pubmed
9933620
uniprot
proteins
sequence_length
260
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted. Cytoplasm. Note=Shows a cytoplasmic distribution in the keratinocytes.
uniprot
proteins