Atp8a2
entrez
50769
canonical
uniprot
P98200
canonical
ensembl
ENSMUSG00000021983
resolver
ensp
ENSMUSP00000079238
resolver
enst
ENSMUST00000080368
resolver
genesymbol
Atp8a2
resolver
uniprot
B2RQF2
resolver
uniprot_entry
AT8A2_MOUSE
resolver
uniprot_sec
B2RQF2
resolver
amino_acid_sequence
MSRATSVGDQLEAPARIIYLNQSHLNKFCDNRISTAKYSVLTFLPRFLYEQIRRAANAFFLFIALLQQIPDVSPTGRYTTLVPLVIILTIAGIKEIIEDFKRHKADNAVNKKKTIVLRNGMWHTIMWKEVAVGDIVKVLNGQYLPADMVLFSSSEPQGMCYVETANLDGETNLKIRQGLSHTTDMQTRDVLMKLSGRIECEGPNRHLYDFTGNLHLDGKSSVALGPDQILLRGTQLRNTQWVFGVVVYTGHDSKLMQNSTKAPLKRSNVEKVTNVQILVLFGILLVMALVSSVGALFWNGSHGGKSWYIKKMDTNSDNFGYNLLTFIILYNNLIPISLLVTLEVVKYTQALFINWDMDMYYIENDTPAMARTSNLNEELGQVKYLFSDKTGTLTCNIMNFKKCSIAGVTYGHFPELAREQSSDDFCRMTSCTNDSCDFNDPRLLKNIEDQHPTAPCIQEFLTLLAVCHTVVPEKDGDEIIYQASSPDEAALVKGAKKLGFVFTGRTPYSVIIEAMGQEQTFGILNVLEFSSDRKRMSVIVRLPSGQLRLYCKGADNVIFERLSKDSKYMEETLCHLEYFATEGLRTLCVAYADLSENEYEEWLKVYQEASIILKDRAQRLEECYEIIEKNLLLLGATAIEDRLQAGVPETIATLLKAEIKIWVLTGDKQETAINIGYSCRLVSQNMALILLKEDSLDATRAAITQHCTDLGNLLGKENDVALIIDGHTLKYALSFEVRRSFLDLALSCKAVICCRVSPLQKSEIVDVVKKRVKAITLAIGDGANDVGMIQTAHVGVGISGNEGMQATNNSDYAIAQFSYLEKLLLVHGAWSYNRVTKCILYCFYKNVVLYIIELWFAFVNGFSGQILFERWCIGLYNVIFTALPPFTLGIFERSCTQESMLRFPQLYRITQNAEGFNTKVFWGHCINALVHSLILFWVPMKALEHDTPVTSGHATDYLFVGNIVYTYVVVTVCLKAGLETTAWTKFSHLAVWGSMLIWLVFFGVYSTIWPTIPIAPDMKGQATMVLSSAYFWLGLFLVPTACLIEDVAWRAAKHTCKKTLLEEVQELETKSRVMGKAMLRDSNGKRMNERDRLIKRLSRKTPPTLFRTGSIQQCVSHGYAFSQEEHGAVTQEEIVRAYDTTKENSRKK
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Atp8a2 are the cause of Wabbler-lethal (wl) phenotype. Homozygotes show severe neurological annormalities that include ataxia and body tremors linked to progressive axonal degeneration in several areas of the nervous system. {ECO:0000269|PubMed:22912588}.
uniprot
proteins
ec_number
7.6.2.1
uniprot
proteins
function
FUNCTION: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids (PubMed:22912588). Able to translocate phosphatidylserine, but not phosphatidylcholine (By similarity). Phospholipid translocation also seems to be implicated in vesicle formation and in uptake of lipid signaling molecules. Reconstituted to liposomes, the ATP8A2:CDC50A flippase complex predominantly transports phosphatidylserine (PS) and to a lesser extent phosphatidylethanolamine (PE) (PubMed:22912588). Phospholipid translocation is not associated with a countertransport of an inorganic ion or other charged substrate from the cytoplasmic side toward the exoplasm in connection with the phosphorylation from ATP (By similarity). ATP8A2:CDC50A may be involved in regulation of neurite outgrowth (PubMed:22641037). Proposed to function in the generation and maintenance of phospholipid asymmetry in photoreceptor disk membranes and neuronal axon membranes. May be involved in vesicle trafficking in neuronal cells. Required for normal visual and auditory function; involved in photoreceptor and inner ear spiral ganglion cell survival (PubMed:24413176). {ECO:0000250|UniProtKB:C7EXK4, ECO:0000250|UniProtKB:Q9NTI2, ECO:0000269|PubMed:22641037, ECO:0000269|PubMed:22912588, ECO:0000269|PubMed:24413176}.
uniprot
proteins
mass_dalton
129417
uniprot
proteins
mutagenesis
MUTAGEN 388; /note="D->A: Abolishes phosphatidylserine translocase activity, abolishes effect on neurite outgrowth."; /evidence="ECO:0000269|PubMed:22641037, ECO:0000269|PubMed:22912588
uniprot
proteins
protein_family
Cation transport ATPase (P-type) (TC 3.A.3) family
uniprot
proteins
protein_family
Type IV subfamily
uniprot
proteins
pubmed
11015572
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19778899
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22641037
uniprot
proteins
pubmed
22912588
uniprot
proteins
pubmed
24413176
uniprot
proteins
sequence_length
1148
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:24413176}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:24413176}. Endosome membrane {ECO:0000269|PubMed:24413176}. Cell membrane {ECO:0000269|PubMed:24413176}. Photoreceptor outer segment membrane {ECO:0000269|PubMed:24413176}. Photoreceptor inner segment membrane {ECO:0000250|UniProtKB:C7EXK4}. Note=Localizes to the Golgi and endosomes in photoreceptor cells (PubMed:24413176). Localizes to disk membranes of rod photoreceptor outer segments (ROS) (By similarity). {ECO:0000250|UniProtKB:C7EXK4, ECO:0000269|PubMed:24413176}.
uniprot
proteins
transmembrane_region
TRANSMEM 45..66; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 72..94; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 277..298; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 324..345; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 838..858; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 871..890; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 921..942; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 957..979; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 986..1006; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1025..1049; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins