Tmbim6
entrez
110213
canonical
uniprot
Q9D2C7
canonical
ensembl
ENSMUSG00000023010
resolver
ensp
ENSMUSP00000023749
resolver
ensp
ENSMUSP00000124651
resolver
ensp
ENSMUSP00000125117
resolver
ensp
ENSMUSP00000125318
resolver
ensp
ENSMUSP00000125563
resolver
ensp
ENSMUSP00000283653
resolver
enst
ENSMUST00000023749
resolver
enst
ENSMUST00000159209
resolver
enst
ENSMUST00000159531
resolver
enst
ENSMUST00000160635
resolver
enst
ENSMUST00000161250
resolver
genesymbol
Tmbim6
resolver
genesymbol_syn
Tegt
resolver
uniprot
Q3TX81
resolver
uniprot
Q8BFY4
resolver
uniprot_entry
BI1_MOUSE
resolver
uniprot_sec
Q3TX81
resolver
uniprot_sec
Q8BFY4
resolver
amino_acid_sequence
MNIFDRKINFDALLKFSHITPSTQQHLKKVYASFALCMFVAAAGAYVHVVTHFIQAGLLSALGSLALMIWLMATPHSHETEQKRLGLLAGFAFLTGVGLGPALELCIAVNPSILPTAFMGTAMIFTCFSLSALYARRRSYLFLGGILMSAMSLMLLSSLGNLFFGSIWLFQANLYLGLLVMCGFVLFDTQLIIEKAEHGDKDYIWHCVDLFLDFVTLFRKLMLILAFNEKDKKKEKK
uniprot
proteins
function
FUNCTION: Endoplasmic reticulum (ER)-resident protein that confers cellular protection as an anti-apoptotic protein by limiting multiple stress-inducing pathways surrounding the endoplasmic reticulum and mitochondria (PubMed:15304216). Inhibits the activities of the key sensor for the endoplasmic reticulum unfolded protein response IRE1alpha/ERN1 both directly and by blocking BAX/BAK binding. Modulates ER calcium homeostasis by acting as a calcium-leak channel (By similarity). Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (PubMed:21926971). {ECO:0000250|UniProtKB:P55061, ECO:0000269|PubMed:15304216, ECO:0000269|PubMed:21926971}.
uniprot
proteins
mass_dalton
26478
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by BFAR, leading to proteasomal degradation. {ECO:0000250|UniProtKB:P55061}.
uniprot
proteins
protein_family
BI1 family
uniprot
proteins
pubmed
15304216
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21926971
uniprot
proteins
pubmed
8012111
uniprot
proteins
sequence_length
237
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P55061}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P55061}.
uniprot
proteins
transmembrane_region
TRANSMEM 30..50; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 53..73; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 87..107; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 113..133; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 140..160; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 167..187; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins