Ifi30
entrez
290644
canonical
uniprot
Q499T2
canonical
ensembl
ENSRNOG00000019387
resolver
ensembl
ENSRNOG00055009609
resolver
ensembl
ENSRNOG00060010787
resolver
ensembl
ENSRNOG00065023771
resolver
ensp
ENSRNOP00000026225
resolver
ensp
ENSRNOP00055013055
resolver
ensp
ENSRNOP00060014226
resolver
ensp
ENSRNOP00065033231
resolver
enst
ENSRNOT00000026225
resolver
enst
ENSRNOT00055016247
resolver
enst
ENSRNOT00060018266
resolver
enst
ENSRNOT00065040742
resolver
genesymbol
Ifi30
resolver
uniprot
Q5I0J7
resolver
uniprot_entry
GILT_RAT
resolver
uniprot_sec
Q5I0J7
resolver
amino_acid_sequence
MSCSPLVPFLSLLLLLFLPEVPRAATASLPQGSSEGAATCKAHDLCLFGPRRLLSAPPVNVSLYYESLCGACRYFLVRNLFPTWLMVMEIMNITLVPYGNAQERNVSGTWEFTCQHGELECKLNKVEACLLDKLEKEAAFLTIVCMEEMEDMEKKLGPCLQLYVPEVSPESIMECATGKRGTELMHENAQLTDALQPPHEYVPWVLVNEKPLTDPSQLLSSVCELYQGTEKPDICSSMADAPREVCYK
uniprot
proteins
ec_number
1.8.4.-
uniprot
proteins
function
FUNCTION: Lysosomal thiol reductase that catalyzes protein disulfide bonds reduction. Plays an important role in antigen processing and presentation, of namely both major histocompatibility complex (MHC) class I- and class II-restricted antigen by reducing the disulfide bonds of endocytosed proteins and facilitating their unfolding and optimal degradation. Shares with thioredoxin a reduction mechanism in which the N-terminal cysteine thiol group in the CXXC active site motif initiates a nucleophilic attack on the substrate disulfide bond,resulting in the formation of a mixed disulfide-linked enzyme-substrate intermediate. Subsequent intramolecular attack by the second cysteine thiol group enables the release of the reduced substrate and oxidized enzyme. Lysosomal cysteine is a physiological reducing agent that is capable of reducing IFI30, so that it can catalyzes the next reaction. Dithiothreitol, cysteine, and cysteinyl glycine, but not glutathione, are capable of regenerating active precursor and mature IFI30 in vitro. {ECO:0000250|UniProtKB:P13284}.
uniprot
proteins
mass_dalton
27644
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. Sugar chains contain mannose-6-phosphate. {ECO:0000250|UniProtKB:P13284}.; PTM: Synthesized as a 35 kDa precursor which is then processed into the mature 30 kDa form via cleavage of N-terminal and C-terminal propeptides. Processing of the precursor is mediated by multiple lysosomal proteases. {ECO:0000250|UniProtKB:P13284}.
uniprot
proteins
protein_family
GILT family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
248
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P13284}. Lysosome {ECO:0000250|UniProtKB:P13284}. Note=A small amount of the precursor can be secreted outside the cell as a dimer. {ECO:0000250|UniProtKB:P13284}.
uniprot
proteins