Tctn1
entrez
654470
canonical
uniprot
Q8BZ64
canonical
ensembl
ENSMUSG00000038593
resolver
ensp
ENSMUSP00000107367
resolver
genesymbol
Tctn1
resolver
genesymbol_syn
Tect1
resolver
uniprot
Q3UMP0
resolver
uniprot
Q8BUE2
resolver
uniprot_entry
TECT1_MOUSE
resolver
uniprot_sec
Q3UMP0
resolver
uniprot_sec
Q8BUE2
resolver
amino_acid_sequence
MGSRGLPPLLLVLLNCYTSSSTQVIAIPAAATPAVTKEDLNSTKATPTTLQPSLSPRTPGTPRAPERSGPRPTPVTDVAALCVCDLLPAQCDVNCCCDPDCSPADFSIFSACSVPVVTGDRQFCSQKAAFYSMNLTADPPHRDFKLIDQINPSVFCIHISNYKPALSFANPEVPDENNFDRLMQTSGGFTLSAESAVPSTAASDGPQPTKYEYGAPLQTAGASSGSFLKLPSPLTSSLCADQNPAAFLVSQAFECSRRVDIEQCEGMEALSMAHYSSPAILRVPNSMTQVSIKIQSVMYRSLNHTLTQLEGHGVLRPSLVSTGQDRLCSNVVLQVKYSLLYTATGQIHEAGLSLVLGTLSSAVSLLQQKFEIHFIQHGTKPVPLSGNPGYRVGLPLAAGFQPQKGSGIIQTTNRQGQFTILRSTSQQDCLASEGLRTPVLFGYNVQSGCQLRLTGTIPCGLLAQKVQDLLRGQAFPDYVAAFGNSRAQDVQDWVPVHFVTYSSNMKGSCQLPVALAIEVKWTKYGSLLNPQARIVNVTAQLVSVPEPLPGPERTVVISTAVTFVDVSAPAEAGFRAPPTINARLPFSFFFPFV
uniprot
proteins
function
FUNCTION: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23. {ECO:0000269|PubMed:16357211, ECO:0000269|PubMed:21725307, ECO:0000269|PubMed:22179047}.
uniprot
proteins
mass_dalton
63447
uniprot
proteins
protein_family
Tectonic family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16357211
uniprot
proteins
pubmed
21565611
uniprot
proteins
pubmed
21725307
uniprot
proteins
pubmed
22179047
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
593
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium basal body. Secreted. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. Despite the presence of a signal sequence, the full-length protein might not be secreted (PubMed:16357211). {ECO:0000269|PubMed:16357211}.
uniprot
proteins