Pip4k2c
entrez
140607
canonical
uniprot
O88370
canonical
ensembl
ENSRNOG00000005138
resolver
ensp
ENSRNOP00000061758
resolver
enst
ENSRNOT00000067774
resolver
genesymbol
Pip4k2c
resolver
genesymbol_syn
Pip5k2c
resolver
uniprot
G3V9W5
resolver
uniprot_entry
G3V9W5_RAT
resolver
uniprot_entry
PI42C_RAT
resolver
amino_acid_sequence
MASSSVPPATAPAAAGGPGPGFGFASKTKKKHFVQQKVKVFRAADPLVGVFLWGVAHSINELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFAIDDHDYLVSLTRSPPSETEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVENEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKVFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEGPVREEESEWDGDCNLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPEGGVFHGLIDILTQYDAKKKAAHAAKTVKHGAGAEISTVHPEQYAKRFLDFISNIFA
uniprot
proteins
ec_number
2.7.1.149
uniprot
proteins
function
FUNCTION: Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity (PubMed:9685379). May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity (By similarity). PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (By similarity). {ECO:0000250|UniProtKB:Q8TBX8, ECO:0000269|PubMed:9685379}.
uniprot
proteins
mass_dalton
47049
uniprot
proteins
post_translational_modification
PTM: Phosphorylated, phosphorylation is induced by EGF. {ECO:0000269|PubMed:9685379}.
uniprot
proteins
pubmed
9685379
uniprot
proteins
sequence_length
420
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:9685379}. Cytoplasm {ECO:0000269|PubMed:9685379}.
uniprot
proteins