Pla2g5
entrez
18784
canonical
uniprot
P97391
canonical
ensembl
ENSMUSG00000041193
resolver
ensp
ENSMUSP00000030524
resolver
ensp
ENSMUSP00000099569
resolver
ensp
ENSMUSP00000099570
resolver
ensp
ENSMUSP00000099571
resolver
ensp
ENSMUSP00000243079
resolver
ensp
ENSMUSP00000243083
resolver
ensp
ENSMUSP00000338245
resolver
enst
ENSMUST00000030524
resolver
enst
ENSMUST00000102511
resolver
enst
ENSMUST00000102512
resolver
enst
ENSMUST00000102513
resolver
genesymbol
Pla2g5
resolver
uniprot
A0ACM8Q4D2
resolver
uniprot
E9PZD1
resolver
uniprot
Q6GTW1
resolver
uniprot
Q9QZU6
resolver
uniprot_entry
A0ACM8Q4D2_MOUSE
resolver
uniprot_entry
PA2G5_MOUSE
resolver
uniprot_entry
Q6GTW1_MOUSE
resolver
uniprot_sec
E9PZD1
resolver
uniprot_sec
Q9QZU6
resolver
amino_acid_sequence
MKGLLTLAWFLACSVPAVPGGLLELKSMIEKVTGKNAFKNYGFYGCYCGWGGRGTPKDGTDWCCQMHDRCYGQLEEKDCAIRTQSYDYRYTNGLVICEHDSFCPMRLCACDRKLVYCLRRNLWTYNPLYQYYPNFLC
uniprot
proteins
ec_number
3.1.1.4
uniprot
proteins
function
FUNCTION: Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity), preferentially releasing fatty acyl groups with a low degree of unsaturation such as oleoyl (C18:1) and linoleoyl (C18:2) groups (PubMed:14962950). Hydrolyzes low-density lipoprotein (LDL) phospholipids releasing unsaturated fatty acids that drive macrophage polarization toward an M2 phenotype (PubMed:14962950, PubMed:24910243). May act in an autocrine and paracrine manner. Contributes to lipid remodeling of cellular membranes at different subcellular locations and generation of lipid mediators involved in pathogen clearance. Cleaves sn-2 fatty acyl chains of cardiolipin, a major component of the inner membrane of mitochondria and bacterial membranes (By similarity). Promotes phagocytosis of bacteria in macrophages through production of lysophosphatidylethanolamines (By similarity). Displays bactericidal activity against Gram-positive bacteria by directly hydrolyzing the phospholipids of the bacterial membrane (PubMed:11694541, PubMed:16407308). Promotes phagocytosis and killing of ingested fungi likely through controlling phagosome-lysosome fusion and phagosome maturation (PubMed:19342668). Plays a role in biosynthesis of cysteinyl leukotrienes (CysLTs) in myeloid cells (By similarity). In eosinophils, triggers perinuclear arachidonate release and LTC4 synthesis in a PLA2G4A-independent way (By similarity). In neutrophils, amplifies CysLTs biosynthesis initiated by PLA2G4A (By similarity). Promotes immune complex clearance in macrophages via stimulating synthesis of CysLTs, which act through CYSLTR1 to trigger phagocytosis (PubMed:20432503). May regulate antigen processing in antigen-presenting cells (PubMed:20817863). In pulmonary macrophages regulates IL33 production required for activation of group 2 innate lymphoid cells (PubMed:29346348). May play a role in the biosynthesis of N-acyl ethanolamines that regulate energy metabolism. Hydrolyzes N-acyl phosphatidylethanolamines to N-acyl lysophosphatidylethanolamines, which are further cleaved by a lysophospholipase D to release N-acyl ethanolamines (By similarity). {ECO:0000250|UniProtKB:P39877, ECO:0000269|PubMed:11694541, ECO:0000269|PubMed:14962950, ECO:0000269|PubMed:16407308, ECO:0000269|PubMed:19342668, ECO:0000269|PubMed:20432503, ECO:0000269|PubMed:20817863, ECO:0000269|PubMed:24910243, ECO:0000269|PubMed:29346348}.
uniprot
proteins
mass_dalton
15859
uniprot
proteins
mutagenesis
MUTAGEN 67; /note="H->Q: Impairs cysteinyl leukotrienes synthesis and phagocytosis of IgG immune complexes by synovial fluid monocyte/macrophage cells."; /evidence="ECO:0000269|PubMed:20432503
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; phospholipid metabolism. {ECO:0000250|UniProtKB:P39877}.; PATHWAY: Lipid metabolism; leukotriene B4 biosynthesis. {ECO:0000250|UniProtKB:P39877}.; PATHWAY: Lipid metabolism; leukotriene C4 biosynthesis. {ECO:0000250|UniProtKB:P39877}.
uniprot
proteins
post_translational_modification
PTM: This enzyme lacks one of the seven disulfide bonds found in similar PA2 proteins.
uniprot
proteins
protein_family
Phospholipase A2 family
uniprot
proteins
pubmed
10531350
uniprot
proteins
pubmed
11694541
uniprot
proteins
pubmed
14962950
uniprot
proteins
pubmed
16407308
uniprot
proteins
pubmed
19342668
uniprot
proteins
pubmed
20432503
uniprot
proteins
pubmed
20817863
uniprot
proteins
pubmed
24910243
uniprot
proteins
pubmed
29346348
uniprot
proteins
pubmed
8838795
uniprot
proteins
sequence_length
137
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10531350}. Cell membrane {ECO:0000269|PubMed:10531350}. Cytoplasmic vesicle, phagosome {ECO:0000269|PubMed:16407308}. Recycling endosome {ECO:0000269|PubMed:16407308}. Golgi apparatus, cis-Golgi network {ECO:0000269|PubMed:16407308}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:16407308}.
uniprot
proteins