Pde12
entrez
211948
canonical
uniprot
Q3TIU4
canonical
ensembl
ENSMUSG00000043702
resolver
ensp
ENSMUSP00000059666
resolver
enst
ENSMUST00000052932
resolver
genesymbol
Pde12
resolver
uniprot
Q3TTY4
resolver
uniprot
Q6P2L5
resolver
uniprot
Q8BKH8
resolver
uniprot
Q8BTS8
resolver
uniprot
Q8BUQ5
resolver
uniprot_entry
PDE12_MOUSE
resolver
uniprot_sec
Q3TTY4
resolver
uniprot_sec
Q6P2L5
resolver
uniprot_sec
Q8BKH8
resolver
uniprot_sec
Q8BTS8
resolver
uniprot_sec
Q8BUQ5
resolver
amino_acid_sequence
MWRLPGRSALRGVRSVVERRSRAEAGTHEAVRAMERAVVRCVPSEPKLSLSFALADGSHKNMQRDQSEPLGRALSRIATNALKGHAKVAAAKKSRKNRAHSSGGAACEATGPEPVATCEPVVKLYYREEAVAEDVLNVDAWQDGAVLQIGDVKYKVERNPPTFTELQLPRYIMAGFPVCPKLGVEFGDPASSVFRWYKEVKPGAAEPGDSGPASSSHSSQPSAWIETGVDERVYTPCNADIGLRLRLHCTPGNGQRFGPSRELESLCPVEAGPGTCTFDHRHLYTKKVTEDSFIRTVSYNILADTYAQTEFSRTVLYPYCAPYALELDYRQNLIQKELTGYNADLICLQEVDRAVFSDSLVPALEAFGLEGVFRIKQHEGLATFYRKSKFRLLSQHDISFQEALKSDPLHKELLEKLALNPLAQEKVLQRSSVLQISVLQSTTDSSKKICVANTHLYWHPKGGYIRLIQMEVALVHIRHVSRDLYPGIPVIFCGDFNSTPSTGMYHFVISGSIAEDHEDWASNGEEERCSMPLSHCFKLKSACGEPAYTNYVGGFHGCLDYIFIDLNTLEVEQVIPLPSHEEVTTHQALPSVSHPSDHIALVCDLKWK
uniprot
proteins
ec_number
3.1.13.4
uniprot
proteins
ec_number
3.1.4.-
uniprot
proteins
function
FUNCTION: Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells. {ECO:0000250|UniProtKB:Q6L8Q7}.
uniprot
proteins
mass_dalton
67514
uniprot
proteins
protein_family
CCR4/nocturin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
608
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:Q6L8Q7}.
uniprot
proteins