TRPM5
entrez
29850
canonical
uniprot
Q9NZQ8
canonical
ensembl
ENSG00000070985
resolver
ensp
ENSP00000436809
resolver
ensp
ENSP00000512529
resolver
genesymbol
TRPM5
resolver
genesymbol_syn
LTRPC5
resolver
genesymbol_syn
MTR1
resolver
hgnc
HGNC:14323
resolver
uniprot
A6NHS0
resolver
uniprot
Q52LU2
resolver
uniprot
Q9NY34
resolver
uniprot_entry
TRPM5_HUMAN
resolver
uniprot_sec
A6NHS0
resolver
uniprot_sec
Q52LU2
resolver
uniprot_sec
Q9NY34
resolver
activity_regulation
ACTIVITY REGULATION: Ca(2+)-activated cation channel (PubMed:14634208). Regulated by PI(4,5)P2 levels. PI(4,5)P 2 reverses the Ca(2+) -induced desensitization of channels (PubMed:14634208). TRPM5 is temperature-sensitive and activated by heat. Heat activation is due to a shift of the voltage-dependent activation curve to negative potentials. The channel is blocked by extracellular acidification (By similarity). {ECO:0000250|UniProtKB:Q9JJH7, ECO:0000269|PubMed:14634208}.
uniprot
proteins
amino_acid_sequence
MQDVQGPRPGSPGDAEDRRELGLHRGEVNFGGSGKKRGKFVRVPSGVAPSVLFDLLLAEWHLPAPNLVVSLVGEEQPFAMKSWLRDVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAVRDHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQEDFPVHYPEDDGGSQGPLCSLDSNLSHFILVEPGPPGKGDGLTELRLRLEKHISEQRAGYGGTGSIEIPVLCLLVNGDPNTLERISRAVEQAAPWLILVGSGGIADVLAALVNQPHLLVPKVAEKQFKEKFPSKHFSWEDIVRWTKLLQNITSHQHLLTVYDFEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDRVDIAKSEIFNGDVEWKSCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYRSVSRKSLLFDLLQRKQEEARLTLAGLGTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRGFYQDGRPGDRRRAEKGPAKRPTGQKWLLDLNQKSENPWRDLFLWAVLQNRHEMATYFWAMGQEGVAAALAACKILKEMSHLETEAEAARATREAKYERLALDLFSECYSNSEARAFALLVRRNRCWSKTTCLHLATEADAKAFFAHDGVQAFLTRIWWGDMAAGTPILRLLGAFLCPALVYTNLITFSEEAPLRTGLEDLQDLDSLDTEKSPLYGLQSRVEELVEAPRAQGDRGPRAVFLLTRWRKFWGAPVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVLEEIRQGFFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEAGRTVLAMDFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDGRLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVILLLVTFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFILLSHLSLTLRRVFKKEAEHKREHLERDLPDPLDQKVVTWETVQKENFLSKMEKRRRDSEGEVLRKTAHRVDFIAKYLGGLREQEKRIKCLESQINYCSVLVSSVADVLAQGGGPRSSQHCGEGSQLVAADHRGGLDGWEQPGAGQPPSDT
uniprot
proteins
function
FUNCTION: Monovalent cation-selective ion channel activated by intracellular Ca(2+) in a voltage- and temperature-dependent manner (PubMed:14634208). Mediates the transport of Na(+), K(+) and Cs(+) ions equally well (PubMed:14634208). Activated directly by increase in intracellular Ca(2+), but is impermeable to it (PubMed:14634208). The activation mechanism of TRPM5 involves a multistep process. TRPM5 activation involves ligand binding (i.e., tastant molecule, glucose stimulation) to Gq/G protein-coupled receptors (GPCR) and leads to the breakdown of phosphatidylinositol bisphosphate (PIP2) into diacylglycerol (DAG) and inositol trisphosphate (IP3), IP3 binds to its receptors in the endoplasmic reticulum and cause calcium release. Simultaneously with the intracellular Ca(2+) release, DAG activates the protein kinase C (PKC), which phosphorylates the TRPM5 channel. This phosphorylation combined with the bound Ca(2+), leads to a robust inward current allowing the entry of sodium ions (Na+) into the cell. This ion influx depolarizes the cell membrane, generating action potentials that propagate TRPM5 signals. Is a key player in sensing sweet, umami and bitter stimuli (By similarity). Involved in insulin secretion by pancreatic beta cells (By similarity). {ECO:0000250|UniProtKB:Q9JJH7, ECO:0000269|PubMed:14634208}.
uniprot
proteins
mass_dalton
131451
uniprot
proteins
mutagenesis
MUTAGEN 351; /note="E->A: Alters the voltage sensitivity. Renders TRPM5 voltage-sensitive at high Ca(2+) concentration."; /evidence="ECO:0000269|PubMed:34168372
uniprot
proteins
post_translational_modification
PTM: Ser-129 phosphorylation by PKC, is essential for activating TRPM5 via the G(q) pathway. {ECO:0000250|UniProtKB:Q9JJH7}.
uniprot
proteins
protein_family
LTrpC subfamily
uniprot
proteins
protein_family
TRPM5 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
pubmed
10607831
uniprot
proteins
pubmed
14634208
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
34168372
uniprot
proteins
sequence_length
1165
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000250|UniProtKB:S5UH55}.
uniprot
proteins
transmembrane_region
TRANSMEM 731..755; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:S5UH55"; TRANSMEM 766..785; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:S5UH55"; TRANSMEM 807..825; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:S5UH55"; TRANSMEM 833..855; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:S5UH55"; TRANSMEM 865..894; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:S5UH55"; TRANSMEM 952..986; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:S5UH55
uniprot
proteins