Gskip
entrez
66787
canonical
uniprot
Q8BGR8
canonical
ensembl
ENSMUSG00000044715
resolver
ensp
ENSMUSP00000057939
resolver
genesymbol
Gskip
resolver
genesymbol_syn
4933433P14Rik
resolver
uniprot
Q3TBR1
resolver
uniprot
Q8CDW3
resolver
uniprot
Q8K2G9
resolver
uniprot_entry
GSKIP_MOUSE
resolver
uniprot_entry
Q3TBR1_MOUSE
resolver
uniprot_sec
Q8CDW3
resolver
uniprot_sec
Q8K2G9
resolver
amino_acid_sequence
METDYNPVELSSMSGFEEGSELNGFEGADMKDMQLEAEAVVNDVLFAVNHMFVSKSMPCADDVAYINVETKERNRYCLELTEAGLRVVGYAFDQVEDHLQTPYHETVYSLLDTLSPAYREAFGNALLQRLEALKRDGQS
uniprot
proteins
function
FUNCTION: A-kinase anchoring protein for GSK3B and PKA that regulates or facilitates their kinase activity towards their targets. The ternary complex enhances Wnt-induced signaling by facilitating the GSK3B- and PKA-induced phosphorylation of beta-catenin leading to beta-catenin degradation and stabilization respectively. Upon cAMP activation, the ternary complex contributes to neuroprotection against oxidative stress-induced apoptosis by facilitating the PKA-induced phosphorylation of DML1 and PKA-induced inactivation of GSK3B. During neurite outgrowth promotes neuron proliferation; while increases beta-catenin-induced transcriptional activity through GSK3B kinase activity inhibition, reduces N-cadherin level to promote cell cycle progression (By similarity). May play a role in cleft palate formation and is required for postnatal life through modulation of the activity of GSK3B during development (PubMed:26582204). {ECO:0000250|UniProtKB:Q9P0R6, ECO:0000269|PubMed:26582204}.
uniprot
proteins
mass_dalton
15642
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by GSK3B. {ECO:0000250|UniProtKB:Q9P0R6}.
uniprot
proteins
protein_family
GSKIP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
26582204
uniprot
proteins
sequence_length
139
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9P0R6}. Nucleus {ECO:0000250|UniProtKB:Q9P0R6}.
uniprot
proteins