FKBP1A
entrez
2280
canonical
uniprot
P62942
canonical
ensembl
ENSG00000088832
resolver
ensp
ENSP00000371138
resolver
ensp
ENSP00000371143
resolver
ensp
ENSP00000383003
resolver
ensp
ENSP00000478093
resolver
ensp
ENSP00000503033
resolver
ensp
ENSP00000503152
resolver
ensp
ENSP00000585708
resolver
enst
ENST00000381719
resolver
enst
ENST00000381724
resolver
enst
ENST00000400137
resolver
enst
ENST00000618612
resolver
enst
ENST00000677335
resolver
enst
ENST00000678408
resolver
enst
ENST00000915649
resolver
genesymbol
FKBP1A
resolver
genesymbol_syn
FKBP1
resolver
genesymbol_syn
FKBP12
resolver
hgnc
HGNC:3711
resolver
uniprot
A0A087WTS4
resolver
uniprot
D3DVW6
resolver
uniprot
P20071
resolver
uniprot
Q0VDC6
resolver
uniprot
Q4VC47
resolver
uniprot
Q6FGD9
resolver
uniprot
Q6LEU3
resolver
uniprot
Q9H103
resolver
uniprot
Q9H566
resolver
uniprot_entry
A0A087WTS4_HUMAN
resolver
uniprot_entry
FKB1A_HUMAN
resolver
uniprot_entry
Q0VDC6_HUMAN
resolver
uniprot_sec
D3DVW6
resolver
uniprot_sec
P20071
resolver
uniprot_sec
Q4VC47
resolver
uniprot_sec
Q6FGD9
resolver
uniprot_sec
Q6LEU3
resolver
uniprot_sec
Q9H103
resolver
uniprot_sec
Q9H566
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by both FK506 and rapamycin.
uniprot
proteins
amino_acid_sequence
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
uniprot
proteins
ec_number
5.2.1.8
uniprot
proteins
function
FUNCTION: Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruits SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. {ECO:0000269|PubMed:16720724, ECO:0000269|PubMed:1696686, ECO:0000269|PubMed:1701173, ECO:0000269|PubMed:9233797}.
uniprot
proteins
mass_dalton
11951
uniprot
proteins
protein_family
FKBP-type PPIase family
uniprot
proteins
protein_family
FKBP1 subfamily
uniprot
proteins
pubmed
10025408
uniprot
proteins
pubmed
10358090
uniprot
proteins
pubmed
10656803
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
1375171
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16720724
uniprot
proteins
pubmed
1695378
uniprot
proteins
pubmed
1696686
uniprot
proteins
pubmed
1701173
uniprot
proteins
pubmed
1709301
uniprot
proteins
pubmed
1709302
uniprot
proteins
pubmed
1709363
uniprot
proteins
pubmed
1716149
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22100703
uniprot
proteins
pubmed
2477715
uniprot
proteins
pubmed
7529739
uniprot
proteins
pubmed
7678431
uniprot
proteins
pubmed
7682113
uniprot
proteins
pubmed
8955134
uniprot
proteins
pubmed
9233797
uniprot
proteins
sequence_length
108
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:1701173}. Sarcoplasmic reticulum membrane {ECO:0000250|UniProtKB:P62943}; Peripheral membrane protein {ECO:0000250|UniProtKB:P62943}; Cytoplasmic side {ECO:0000250|UniProtKB:P62943}.
uniprot
proteins