ARRDC1
entrez
92714
canonical
uniprot
Q8N5I2
canonical
ensembl
ENSG00000197070
resolver
ensp
ENSP00000360475
resolver
ensp
ENSP00000528867
resolver
enst
ENST00000371421
resolver
genesymbol
ARRDC1
resolver
hgnc
HGNC:28633
resolver
uniprot_entry
ARRD1_HUMAN
resolver
amino_acid_sequence
MGRVQLFEISLSHGRVVYSPGEPLAGTVRVRLGAPLPFRAIRVTCIGSCGVSNKANDTAWVVEEGYFNSSLSLADKGSLPAGEHSFPFQFLLPATAPTSFEGPFGKIVHQVRAAIHTPRFSKDHKCSLVFYILSPLNLNSIPDIEQPNVASATKKFSYKLVKTGSVVLTASTDLRGYVVGQALQLHADVENQSGKDTSPVVASLLQKVSYKAKRWIHDVRTIAEVEGAGVKAWRRAQWHEQILVPALPQSALPGCSLIHIDYYLQVSLKAPEATVTLPVFIGNIAVNHAPVSPRPGLGLPPGAPPLVVPSAPPQEEAEAEAAAGGPHFLDPVFLSTKSHSQRQPLLATLSSVPGAPEPCPQDGSPASHPLHPPLCISTGATVPYFAEGSGGPVPTTSTLILPPEYSSWGYPYEAPPSYEQSCGGVEPSLTPES
uniprot
proteins
function
FUNCTION: Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed:23886940, PubMed:27462458). Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles (PubMed:27462458). More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles (PubMed:22315426). By participating in the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway (PubMed:23886940). {ECO:0000269|PubMed:22315426, ECO:0000269|PubMed:23886940, ECO:0000269|PubMed:27462458}.
uniprot
proteins
mass_dalton
45981
uniprot
proteins
mutagenesis
MUTAGEN 88; /note="F->L: Loss of localization to the cell membrane and extracellular vesicles. Localizes to the cytoplasm."; /evidence="ECO:0000269|PubMed:22315426"; MUTAGEN 180; /note="G->A: Decreased localization to the cell membrane and extracellular vesicles."; /evidence="ECO:0000269|PubMed:22315426"; MUTAGEN 191; /note="N->D: Decreased localization to the cell membrane and extracellular vesicles."; /evidence="ECO:0000269|PubMed:22315426"; MUTAGEN 310; /note="S->A: Decreased interaction with TSG101. No effect on localization to the cell membrane. Loss of localization to extracellular vesicles."; /evidence="ECO:0000269|PubMed:22315426"; MUTAGEN 403; /note="P->A: Loss of interaction with ITCH; when associated with A-416."; /evidence="ECO:0000269|PubMed:23886940"; MUTAGEN 416; /note="P->A: Loss of interaction with ITCH; when associated with A-403."; /evidence="ECO:0000269|PubMed:23886940
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated (PubMed:21191027, PubMed:22315426). Ubiquitination by WWP2; promotes localization to extracellular microvesicles (PubMed:22315426). Ubiquitinated by WWP1 (PubMed:21191027). {ECO:0000269|PubMed:21191027, ECO:0000269|PubMed:22315426}.
uniprot
proteins
protein_family
Arrestin family
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21191027
uniprot
proteins
pubmed
22315426
uniprot
proteins
pubmed
23886940
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27462458
uniprot
proteins
sequence_length
433
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22315426, ECO:0000269|PubMed:27462458}. Note=Also found in extracellular vesicles different from exosomes. {ECO:0000269|PubMed:22315426, ECO:0000269|PubMed:27462458}.
uniprot
proteins