Sit1
entrez
54390
canonical
uniprot
Q8C503
canonical
ensembl
ENSMUSG00000028460
resolver
ensp
ENSMUSP00000030180
resolver
enst
ENSMUST00000030180
resolver
genesymbol
Sit1
resolver
genesymbol_syn
Sit
resolver
uniprot
Q9WUU5
resolver
uniprot_entry
SIT1_MOUSE
resolver
uniprot_sec
Q9WUU5
resolver
amino_acid_sequence
MSRDYNCTTDDQLAWGIPSISHAWGLWALLGVVTVLLLISLAALLSQWTRGRRRNQEGQGPLSGRSAEEVPLYGNLHYLQTGRLSQEPRSEEQDPPSSGGLARGAEEAMCYTSLQLRPAQGRIPSSGNPIKYCEVVLDSEPKPQAPGPEPELYASVCAQTRRGRASFPDQAYANSQPAPS
uniprot
proteins
function
FUNCTION: Negatively regulates T-cell antigen receptor (TCR)-mediated signaling. Involved in positive selection of T-cells. {ECO:0000269|PubMed:16107703}.
uniprot
proteins
mass_dalton
19578
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosines upon TCR activation; which leads to the recruitment of PTPN11, GRB2 and CSK. {ECO:0000250}.
uniprot
proteins
pubmed
10209036
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16107703
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
180
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..45; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins