HSD3B1
entrez
3283
canonical
uniprot
P14060
canonical
ensembl
ENSG00000203857
resolver
ensp
ENSP00000358421
resolver
ensp
ENSP00000432268
resolver
ensp
ENSP00000771653
resolver
enst
ENST00000369413
resolver
enst
ENST00000528909
resolver
genesymbol
HSD3B1
resolver
genesymbol_syn
3BH
resolver
genesymbol_syn
HSDB3A
resolver
hgnc
HGNC:5217
resolver
uniprot
A8K691
resolver
uniprot
Q14545
resolver
uniprot
Q8IV65
resolver
uniprot_entry
3BHS1_HUMAN
resolver
uniprot_sec
A8K691
resolver
uniprot_sec
Q14545
resolver
uniprot_sec
Q8IV65
resolver
amino_acid_sequence
MTGWSCLVTGAGGFLGQRIIRLLVKEKELKEIRVLDKAFGPELREEFSKLQNKTKLTVLEGDILDEPFLKRACQDVSVIIHTACIIDVFGVTHRESIMNVNVKGTQLLLEACVQASVPVFIYTSSIEVAGPNSYKEIIQNGHEEEPLENTWPAPYPHSKKLAEKAVLAANGWNLKNGGTLYTCALRPMYIYGEGSRFLSASINEALNNNGILSSVGKFSTVNPVYVGNVAWAHILALRALQDPKKAPSIRGQFYYISDDTPHQSYDNLNYTLSKEFGLRLDSRWSFPLSLMYWIGFLLEIVSFLLRPIYTYRPPFNRHIVTLSNSVFTFSYKKAQRDLAYKPLYSWEEAKQKTVEWVGSLVDRHKETLKSKTQ
uniprot
proteins
ec_number
1.1.1.145
uniprot
proteins
ec_number
1.1.1.210
uniprot
proteins
ec_number
1.1.1.270
uniprot
proteins
ec_number
5.3.3.1
uniprot
proteins
function
FUNCTION: A bifunctional enzyme responsible for the oxidation and isomerization of 3beta-hydroxy-Delta(5)-steroid precursors to 3-oxo-Delta(4)-steroids, an essential step in steroid hormone biosynthesis. Specifically catalyzes the conversion of pregnenolone to progesterone, 17alpha-hydroxypregnenolone to 17alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA) to 4-androstenedione, and androstenediol to testosterone. Additionally, catalyzes the interconversion between 3beta-hydroxy and 3-oxo-5alpha-androstane steroids controlling the bioavalability of the active forms. Specifically converts dihydrotestosterone to its inactive form 5alpha-androstanediol, that does not bind androgen receptor/AR. Also converts androstanedione, a precursor of testosterone and estrone, to epiandrosterone (PubMed:1401999, PubMed:2139411). Expected to use NAD(+) as preferred electron donor for the 3beta-hydroxy-steroid dehydrogenase activity and NADPH for the 3-ketosteroid reductase activity (Probable). {ECO:0000269|PubMed:1401999, ECO:0000269|PubMed:2139411, ECO:0000305|PubMed:1401999}.
uniprot
proteins
mass_dalton
42252
uniprot
proteins
pathway_participation
PATHWAY: Steroid hormone biosynthesis. {ECO:0000269|PubMed:1401999}.; PATHWAY: Steroid metabolism. {ECO:0000269|PubMed:1401999}.
uniprot
proteins
protein_family
3-beta-HSD family
uniprot
proteins
pubmed
10391209
uniprot
proteins
pubmed
1401999
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1920284
uniprot
proteins
pubmed
2082186
uniprot
proteins
pubmed
2139411
uniprot
proteins
pubmed
2243100
uniprot
proteins
pubmed
2779585
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 288..308; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins