DAP
entrez
1611
canonical
uniprot
P51397
canonical
ensembl
ENSG00000112977
resolver
ensp
ENSP00000230895
resolver
ensp
ENSP00000394163
resolver
enst
ENST00000230895
resolver
enst
ENST00000432074
resolver
genesymbol
DAP
resolver
genesymbol_syn
DAP1
resolver
hgnc
HGNC:2672
resolver
uniprot
B4DQ75
resolver
uniprot
F6WV43
resolver
uniprot
Q6FGC3
resolver
uniprot
Q9BUC9
resolver
uniprot_entry
B4DQ75_HUMAN
resolver
uniprot_entry
DAP1_HUMAN
resolver
uniprot_entry
F6WV43_HUMAN
resolver
uniprot_sec
Q6FGC3
resolver
uniprot_sec
Q9BUC9
resolver
amino_acid_sequence
MSSPPEGKLETKAGHPPAVKAGGMRIVQKHPHTGDTKEEKDKDDQEWESPSPPKPTVFISGVIARGDKDFPPAAAQVAHQKPHASMDKHPSPRTQHIQQPRK
uniprot
proteins
function
FUNCTION: Ribosome-binding protein involved in ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with eiF5a (EIF5A and EIF5A2) at the polypeptide exit tunnel of the ribosome, preventing mRNA translation (By similarity). Involved in ribosome hibernation in the mature oocyte by preventing mRNA translation, leading to ribosome inactivation (By similarity). Ribosomes, which are produced in large quantities during oogenesis, are stored and translationally repressed in the oocyte and early embryo (By similarity). Also acts as a negative regulator of autophagy (PubMed:20537536). Involved in mediating interferon-gamma-induced cell death (PubMed:7828849). {ECO:0000250|UniProtKB:Q9I9N1, ECO:0000269|PubMed:20537536, ECO:0000269|PubMed:7828849}.
uniprot
proteins
mass_dalton
11165
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy. {ECO:0000269|PubMed:16602700, ECO:0000269|PubMed:20537536}.
uniprot
proteins
protein_family
DAP-DAPL1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16602700
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20537536
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
7828849
uniprot
proteins
sequence_length
102
uniprot
proteins