Irf5
entrez
27056
canonical
uniprot
P56477
canonical
ensembl
ENSMUSG00000029771
resolver
ensp
ENSMUSP00000004392
resolver
ensp
ENSMUSP00000126273
resolver
ensp
ENSMUSP00000127021
resolver
enst
ENSMUST00000004392
resolver
enst
ENSMUST00000163511
resolver
enst
ENSMUST00000167252
resolver
genesymbol
Irf5
resolver
uniprot
F6Z6C6
resolver
uniprot
Q3U169
resolver
uniprot_entry
F6Z6C6_MOUSE
resolver
uniprot_entry
IRF5_MOUSE
resolver
uniprot_entry
Q3U169_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Maintained as a monomer in an autoinhibited state (PubMed:25326420). Phosphorylation and activation follow the following steps: innate adapter protein TASL recruits IRF5, thereby licensing IRF5 for phosphorylation by IKBKB (By similarity). Phosphorylated IRF5 dissociates from the adapter proteins, dimerizes, and then enters the nucleus to induce IFNs (PubMed:25326420). {ECO:0000250|UniProtKB:Q13568, ECO:0000269|PubMed:25326420}.
uniprot
proteins
amino_acid_sequence
MNHSAPGIPPPPRRVRLKPWLVAQVNSCQYPGLQWVNGEKKLFYIPWRHATRHGPSQDGDNTIFKAWAKETGKYTEGVDEADPAKWKANLRCALNKSRDFQLFYDGPRDMPPQPYKIYEVCSNGPAPTESQPTDDYVLGEEEEEEEEELQRMLPGLSITEPALPGPPNAPYSLPKEDTKWPPALQPPVGLGPPVPDPNLLAPPSGNPAGFRQLLPEVLEPGPLASSQPPTEPLLPDLLISPHMLPLTDLEIKFQYRGRAPRTLTISNPQGCRLFYSQLEATQEQVELFGPVTLEQVRFPSPEDIPSDKQRFYTNQLLDVLDRGLILQLQGQDLYAIRLCQCKVFWSGPCALAHGSCPNPIQREVKTKLFSLEQFLNELILFQKGQTNTPPPFEIFFCFGEEWPDVKPREKKLITVQVVPVAARLLLEMFSGELSWSADSIRLQISNPDLKDHMVEQFKELHHLWQSQQQLQPMVQAPPVAGLDASQGPWPMHPVGMQ
uniprot
proteins
function
FUNCTION: Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:15665823). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:15665823). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction downstream of the TLR-activated, MyD88-dependent pathway (PubMed:15665823). {ECO:0000269|PubMed:15665823}.
uniprot
proteins
mass_dalton
56005
uniprot
proteins
mutagenesis
MUTAGEN 434; /note="S->A: Reduced homodimerization and subsequent activation."; /evidence="ECO:0000269|PubMed:25326420"; MUTAGEN 445; /note="S->A: Abolished homodimerization and subsequent activation."; /evidence="ECO:0000269|PubMed:25326420
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of serine and threonine residues by IKBKB in a C-terminal autoinhibitory region, stimulates dimerization, transport into the nucleus, assembly with the coactivator CBP/EP300 and initiation of transcription. Phosphorylation at Thr-264 by STK25 induces IRF5 transcriptional activation. {ECO:0000250|UniProtKB:Q13568, ECO:0000269|PubMed:25326420}.; PTM: 'Lys-63'-linked polyubiquitination by TRAF6 is required for activation. {ECO:0000269|PubMed:18824541}.
uniprot
proteins
protein_family
IRF family
uniprot
proteins
pubmed
15665823
uniprot
proteins
pubmed
18824541
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25326420
uniprot
proteins
sequence_length
497
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15665823, ECO:0000269|PubMed:18824541, ECO:0000269|PubMed:25326420}. Nucleus {ECO:0000269|PubMed:15665823, ECO:0000269|PubMed:18824541, ECO:0000269|PubMed:25326420}. Note=Shuttles between the nucleus and the cytoplasm: upon activation by the TLR adapter MYD88 and subsequent phosphorylation, translocates to the nucleus. {ECO:0000269|PubMed:15665823, ECO:0000269|PubMed:25326420}.
uniprot
proteins