FBXO44
entrez
93611
canonical
uniprot
Q9H4M3
canonical
ensembl
ENSG00000132879
resolver
ensp
ENSP00000251546
resolver
ensp
ENSP00000251547
resolver
ensp
ENSP00000365951
resolver
ensp
ENSP00000365953
resolver
ensp
ENSP00000365959
resolver
ensp
ENSP00000365961
resolver
ensp
ENSP00000528252
resolver
ensp
ENSP00000528253
resolver
ensp
ENSP00000603263
resolver
ensp
ENSP00000722399
resolver
ensp
ENSP00000722406
resolver
enst
ENST00000376768
resolver
genesymbol
FBXO44
resolver
genesymbol_syn
FBG3
resolver
genesymbol_syn
FBX30
resolver
genesymbol_syn
FBX44
resolver
genesymbol_syn
FBX6A
resolver
genesymbol_syn
FBXO6A
resolver
hgnc
HGNC:24847
resolver
uniprot
B3KNZ2
resolver
uniprot
B7Z1P2
resolver
uniprot
B7Z743
resolver
uniprot
F6R692
resolver
uniprot
Q5TGX2
resolver
uniprot
Q5TGX4
resolver
uniprot
Q5TGX5
resolver
uniprot
Q68DJ9
resolver
uniprot
Q8WWY2
resolver
uniprot_entry
B7Z1P2_HUMAN
resolver
uniprot_entry
F6R692_HUMAN
resolver
uniprot_entry
FBX44_HUMAN
resolver
uniprot_sec
B3KNZ2
resolver
uniprot_sec
B7Z743
resolver
uniprot_sec
Q5TGX2
resolver
uniprot_sec
Q5TGX4
resolver
uniprot_sec
Q5TGX5
resolver
uniprot_sec
Q68DJ9
resolver
uniprot_sec
Q8WWY2
resolver
amino_acid_sequence
MAVGNINELPENILLELFTHVPARQLLLNCRLVCSLWRDLIDLVTLWKRKCLREGFITEDWDQPVADWKIFYFLRSLHRNLLHNPCAEEGFEFWSLDVNGGDEWKVEDLSRDQRKEFPNDQVKKYFVTSYYTCLKSQVVDLKAEGYWEELMDTTRPDIEVKDWFAARPDCGSKYQLCVQLLSSAHAPLGTFQPDPATIQQKSDAKWREVSHTFSNYPPGVRYIWFQHGGVDTHYWAGWYGPRVTNSSITIGPPLP
uniprot
proteins
function
FUNCTION: Substrate-recognition component of two distinct E3 ligase complexes, the SKP1-CUL1-FBXO44 complex and the CUL4B-DDB1-FBXO44 complex (PubMed:18203720, PubMed:25970626). The complex SCF(FBXO44) complex ubiquitinates and mediates BRCA1 degradation (PubMed:23086937). In association with cullin 4B/CUL4B and DDB1, mediates the ubiquitination of RGS2 leading to its degradation (PubMed:25970626). Additionally, regulates the pregnane X receptor/NR1I2 protein level by ubiquitination and degradation (PubMed:37969738). {ECO:0000269|PubMed:23086937, ECO:0000269|PubMed:25970626, ECO:0000269|PubMed:37969738}.
uniprot
proteins
mass_dalton
29747
uniprot
proteins
pubmed
12383498
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18203720
uniprot
proteins
pubmed
23086937
uniprot
proteins
pubmed
25970626
uniprot
proteins
pubmed
37969738
uniprot
proteins
sequence_length
255
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23086937}.
uniprot
proteins