Gclc
entrez
25283
canonical
uniprot
P19468
canonical
ensembl
ENSRNOG00000006302
resolver
ensembl
ENSRNOG00055006663
resolver
ensembl
ENSRNOG00060018387
resolver
ensembl
ENSRNOG00065016603
resolver
ensp
ENSRNOP00000035540
resolver
ensp
ENSRNOP00055008452
resolver
ensp
ENSRNOP00060025644
resolver
ensp
ENSRNOP00065021790
resolver
enst
ENSRNOT00000033196
resolver
enst
ENSRNOT00055010868
resolver
enst
ENSRNOT00060031576
resolver
enst
ENSRNOT00065027666
resolver
genesymbol
Gclc
resolver
genesymbol_syn
Glclc
resolver
uniprot_entry
GSH1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Feedback inhibition by glutathione.
uniprot
proteins
amino_acid_sequence
MGLLSQGSPLSWEETQRHADHVRRHGILQFLHIYHAVKDRHKDVLKWGDEVEYMLVSFDHENRKVQLLLNGGDVLETLQEKGERTNPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTVEDNMRKRRKEATSVLGEHQALCTITSFPRLGCPGFTLPEHRPNPEEGGASKSLFFPDEAINKHPRFGTLTRNIRHRRGEKVVINVPIFKDKNTPSPFVETFPEDEEASKASKPDHIYMDAMGFGMGNCCLQVTFQACSISEARYLYDQLATICPIVMALSAASPFYRGYVSDIDCRWGVISASVDDRTREERGLEPLKNNRFKISKSRYDSIDSYLSKCGEKYNDIDLTIDTEIYEQLLEEGIDHLLAQHVAHLFIRDPLTLFEEKIHLDDANESDHFENIQSTNWQTMRFKPPPPNSDIGWRVEFRPMEVQLTDFENSAYVVFVVLLTRVILSYKLDFLIPLSKVDENMKVAQERDAVLQGMFYFRKDICKGGNAVVDGCSKAQTSSEPSAEEYTLMSIDTIINGKEGVFPGLIPILNSYLENMEVDVDTRCSILNYLKLIKKRASGELMTVARWMREFIANHPDYKQDSVITDEINYSLILKCNQIANELCECPELLGSGFRKAKYSGGKSDPSD
uniprot
proteins
ec_number
6.3.2.2
uniprot
proteins
function
FUNCTION: Catalyzes the ATP-dependent ligation of L-glutamate and L-cysteine and participates in the first and rate-limiting step in glutathione biosynthesis. {ECO:0000250|UniProtKB:P48506}.
uniprot
proteins
mass_dalton
72619
uniprot
proteins
pathway_participation
PATHWAY: Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2. {ECO:0000250|UniProtKB:P48506}.
uniprot
proteins
protein_family
Glutamate--cysteine ligase type 3 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1967255
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
637
uniprot
proteins