Piezo2
entrez
667742
canonical
uniprot
Q8CD54
canonical
ensembl
ENSMUSG00000041482
resolver
ensp
ENSMUSP00000040019
resolver
ensp
ENSMUSP00000138758
resolver
enst
ENSMUST00000047480
resolver
enst
ENSMUST00000183217
resolver
genesymbol
Piezo2
resolver
genesymbol_syn
Fam38b
resolver
uniprot
A0A2H4UKA3
resolver
uniprot
E2JF23
resolver
uniprot
E9QNW4
resolver
uniprot
Q8BSM4
resolver
uniprot
Q9D341
resolver
uniprot
S4R2S0
resolver
uniprot_entry
A0A2H4UKA3_MOUSE
resolver
uniprot_entry
E9QNW4_MOUSE
resolver
uniprot_entry
PIEZ2_MOUSE
resolver
uniprot_entry
S4R2S0_MOUSE
resolver
uniprot_sec
E2JF23
resolver
uniprot_sec
Q8BSM4
resolver
uniprot_sec
Q9D341
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by auxillary subunits MDFIC and MDFI (PubMed:37590348). Channel activity is inhibited by TMEM120aa (PubMed:35819364). Phosphatidic acid and lysophosphatidic acid inhibit Piezo2 channel activity (PubMed:39147733). {ECO:0000269|PubMed:35819364, ECO:0000269|PubMed:37590348, ECO:0000269|PubMed:39147733}.
uniprot
proteins
amino_acid_sequence
MASEVVCGLIFRLLLPICLAVACAFRYNGLSFVYLIYLLLIPLFSEPTKATMQGHTGRLLQSLCITSLSFLLLHIIFHITLASLEAQHRITPAYNCSTWEKTFRQIGFESLKGADAGNGIRVFVPDIGMFIASLTIWLVCRTIVKKPDTEEIAQLNSECENEELAGGEKMDSEEALIYEEDLDGEEGMEGELEESTKLKILRRFASVASKLKEFIGNMITTAGKVVVTILLGSSGMMLPSLTSAVYFFVFLGLCTWWSWCRTFDPLLFGCLCVLLAIFTAGHLIGLYLYQFQFFQEAVPPNDYYARLFGIKSVIQTDCASTWKIIVNPDLSWYHHANPILLLVMYYTLATLIRIWLQEPLVQEEMAKEDEGALDCSSNQNTAERRRSLWYATQYPTDERKLLSMTQDDYKPSDGLLVTVNGNPVDYHTIHPSLPIENGPAKTDLYTTPQYRWEPSEESSEKKEEEEDKREDSEGEGSQEEKRSVRMHAMVAVFQFIMKQSYICALIAMMAWSITYHSWLTFVLLIWSCTLWMIRNRRKYAMISSPFMVVYANLLLVLQYIWSFELPEIKKVPGFLEKKEPGELASKILFTITFWLLLRQHLTEQKALREKEALLSEVKIGSQELEEKEDEELQDVQVEGEPTEKEEEEEEEIKEERHEVKKEEEEEVEEDDDQDIMKVLGNLVVALFIKYWIYVCGGMFFFVSFEGKIVMYKIIYMVLFLFCVALYQVHYEWWRKILKYFWMSVVIYTMLVLIFIYTYQFENFPGLWQNMTGLKKEKLEDLGLKQFTVAELFTRIFIPTSFLLVCILHLHYFHDRFLELTDLKSIPSKEDNTIYSHAKVNGRVYLIINRLAHPEGSLPDLAIMNMTASLDKPEVQKLAESGEERPEECVKKTEKGEAGKDSDESEEEEDEEEESEEEESSDLRNKWHLVIDRLTVLFLKFLEYFHKLQVFMWWILELHIIKIVSSYIIWVTVKEVSLFNYVFLISWAFALPYAKLRRAASSVCTVWTCVIIVCKMLYQLQTIKPENFSVNCSLPNENQTNIPLHELNKSLLYSAPVDPTEWVGLRKSSPLLVYLRNNLLMLAILAFEVTVYRHQEYYRGRNNLTAPVSKTIFHDITRLHLDDGLINCAKYFVNYFFYKFGLETCFLMSVNVIGQRMDFYAMIHACWLIGVLYRRRRKAIAEVWPKYCCFLACIITFQYFVCIGIPPAPCRDYPWRFKGAYFNDNIIKWLYFPDFIVRPNPVFLVYDFMLLLCASLQRQIFEDENKAAVRIMAGDNVEICMNLDAASFSQHNPVPDFIHCRSYLDMSKVIIFSYLFWFVLTIIFITGTTRISIFCMGYLVACFYFLLFGGDLLLKPIKSILRYWDWLIAYNVFVITMKNILSIGACGYIGALVRNSCWLIQAFSLACTVKGYQMPEDDSRCKLPSGEAGIIWDSICFAFLLLQRRVFMSYYFLHVVADIKASQILASRGAELFQATIVKAVKARIEEEKKSMDQLKRQMDRIKARQQKYKKGKERMLSLTQESGEGQDIQKVSEEDDEREADKQKAKGKKKQWWRPWVDHASMVRSGDYYLFETDSEEEEEEELKKEDEEPPRKSAFQFVYQAWITDPKTALRQRRKEKKKLAREEQKERRKGSGDGPVEWEDREDEPVKKKSDGPDNIIKRIFNILKFTWVLFLATVDSFTTWLNSISREHIDISTVLRIERCMLTREIKKGNVPTRESIHMYYQNHIMNLSRESGLDTIDEHSGAGSRAQAAHRMDSLDSRDSISSCYTEATLLISRQSTLDDLDGQDPVPKTSERARPRLRKMFSLDMSSSSADSGSVASSEPTQCTMLYSRQGTTETIEEVEAEAEEEVVEGLEPELHDAEEKEYAAEYEAGVEEISLTPDEELPQFSTDDCEAPPSYSKAVSFEHLSFASQDDSGAKNHMVVSPDDSRTDKLESSILPPLTHELTASDLLMSKMFHDDELEESEKFYVDQPRFLLLFYAMYNTLVARSEMVCYFVIILNHMTSASIITLLLPILIFLWAMLSVPRPSRRFWMMAIVYTEVAIVVKYFFQFGFFPWNKDLEIYKERPYFPPNIIGVEKKEGYVLYDLIQLLALFFHRSILKCHGLWDEDDIVDSNTDKEGSDDELSLDQGRRGSSDSLKSINLAASVESVHVTFPEQPAAIRRKRSCSSSQISPRSSFSSNRSKRGSTSTRNSSQKGSSVLSLKQKSKRELYMEKLQEHLIKAKAFTIKKTLQIYVPIRQFFYDLIHPDYSAVTDVYVLMFLADTVDFIIIVFGFWAFGKHSAAADITSSLSEDQVPGPFLVMVLIQFGTMVVDRALYLRKTVLGKVIFQVILVFGIHFWMFFILPGVTERKFSQNLVAQLWYFVKCVYFGLSAYQIRCGYPTRVLGNFLTKSYNYVNLFLFQGFRLVPFLTELRAVMDWVWTDTTLSLSSWICVEDIYAHIFILKCWRESEKRYPQPRGQKKKKAVKYGMGGMIIVLLICIVWFPLLFMSLIKSVAGVINQPLDVSVTITLGGYQPIFTMSAQQSQLKVMDNSKYNEFLKSFGPNSGAMQFLENYEREDVTVAELEGNSNSLWTISPPSKQKMIQELTDPNSCFSVVFSWSIQRNMTLGAKAEIATDKLSFPLAVATRNSIAKMIAGNDTESSNTPVTIEKIYPYYVKAPSDSNSKPIKQLLSENNFMNITIILFRDNVTKSNSEWWVLNLTGSRIFNQGSQALELVVFNDKVSPPSLGFLAGYGIMGLYASVVLVIGKFVREFFSGISHSIMFEELPNVDRILKLCTDIFLVRETGELELEEDLYAKLIFLYRSPETMIKWTREKTN
uniprot
proteins
function
FUNCTION: Pore-forming subunit of the mechanosensitive non-specific cation Piezo channel required for rapidly adapting mechanically activated (MA) currents and has a key role in sensing touch and tactile pain (PubMed:20813920, PubMed:24717433, PubMed:31435011, PubMed:37590348). Piezo channels are homotrimeric three-blade propeller-shaped structures that utilize a cap-motion and plug-and-latch mechanism to gate their ion-conducting pathways (PubMed:31435011, PubMed:37590348). Expressed in sensory neurons, is essential for diverse physiological processes, including respiratory control, systemic metabolism, urinary function, and proprioception (PubMed:26551544, PubMed:28002412, PubMed:33057202, PubMed:39919739). Mediates airway stretch sensing, enabling efficient respiration at birth and maintaining normal breathing in adults (PubMed:28002412). It regulates brown and beige adipose tissue morphology and function, preventing systemic hypermetabolism (PubMed:39919739). In the lower urinary tract, acts as a sensor in both the bladder urothelium and innervating sensory neurons and is required for bladder-stretch sensing and urethral micturition reflexes, ensuring proper urinary function (PubMed:33057202). Additionally, Piezo2 serves as the principal mechanotransducer in proprioceptors, facilitating proprioception and coordinated body movements (PubMed:26551544). In inner ear hair cells, PIEZO1/2 subunits may constitute part of the mechanotransducer (MET) non-selective cation channel complex where they may act as pore-forming ion-conducting component in the complex (PubMed:38228630). Required for Merkel-cell mechanotransduction (PubMed:24717433). Plays a major role in light-touch mechanosensation (PubMed:25471886). In kidney, during blood volume challenges, regulates calcium dynamics and maintains renin production, thereby serving as an essential regulator of the renin-angiotensin-aldosterone system (RAAS) and systemic blood volume control (PubMed:41349545). {ECO:0000269|PubMed:20813920, ECO:0000269|PubMed:24717433, ECO:0000269|PubMed:25471886, ECO:0000269|PubMed:26551544, ECO:0000269|PubMed:28002412, ECO:0000269|PubMed:31435011, ECO:0000269|PubMed:33057202, ECO:0000269|PubMed:37590348, ECO:0000269|PubMed:38228630, ECO:0000269|PubMed:39919739, ECO:0000269|PubMed:41349545}.
uniprot
proteins
mass_dalton
325628
uniprot
proteins
mutagenesis
MUTAGEN 2757; /note="E->A: Reduces to around 50% the permeability of Ca(2+)."; /evidence="ECO:0000269|PubMed:31435011"; MUTAGEN 2767..2770; /note="MFEE->AAAA: Hearing and vestibular impairment in conditional knockin mice in inner ear hair cells."; /evidence="ECO:0000269|PubMed:38228630
uniprot
proteins
protein_family
PIEZO (TC 1.A.75) family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20813920
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22343900
uniprot
proteins
pubmed
24662763
uniprot
proteins
pubmed
24717433
uniprot
proteins
pubmed
25471886
uniprot
proteins
pubmed
26551544
uniprot
proteins
pubmed
28002412
uniprot
proteins
pubmed
31435011
uniprot
proteins
pubmed
33057202
uniprot
proteins
pubmed
35819364
uniprot
proteins
pubmed
37590348
uniprot
proteins
pubmed
38228630
uniprot
proteins
pubmed
38568807
uniprot
proteins
pubmed
39147733
uniprot
proteins
pubmed
39919739
uniprot
proteins
pubmed
41349545
uniprot
proteins
sequence_length
2822
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:38228630, ECO:0000305|PubMed:25471886}; Multi-pass membrane protein {ECO:0000269|PubMed:31435011}. Note=Located at the tips and sides of stereocilia and cuticular plate membranes. {ECO:0000269|PubMed:38228630}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..24; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 31..43; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 51..76; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 123..141; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 222..237; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 241..258; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 265..287; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 336..355; /note="Helical; Name=8"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 493..514; /note="Helical; Name=9"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 520..531; /note="Helical; Name=10"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 536..562; /note="Helical; Name=11"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 584..614; /note="Helical; Name=12"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 690..703; /note="Helical; Name=13"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 710..728; /note="Helical; Name=14"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 738..757; /note="Helical; Name=15"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 790..811; /note="Helical; Name=16"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 958..973; /note="Helical; Name=17"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 980..989; /note="Helical; Name=18"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 998..1018; /note="Helical; Name=19"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 1075..1099; /note="Helical; Name=20"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 1141..1155; /note="Helical; Name=21"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 1158..1171; /note="Helical; Name=22"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 1183..1202; /note="Helical; Name=23"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 1240..1260; /note="Helical; Name=24"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 1315..1327; /note="Helical; Name=25"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 1334..1346; /note="Helical; Name=26"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 1356..1381; /note="Helical; Name=27"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 1431..1447; /note="Helical; Name=28"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 1992..2006; /note="Helical; Name=29"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 2014..2025; /note="Helical; Name=30"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 2032..2053; /note="Helical; Name=31"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 2087..2105; /note="Helical; Name=32"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 2260..2279; /note="Helical; Name=33"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 2302..2322; /note="Helical; Name=34"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 2327..2350; /note="Helical; Name=35"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 2360..2382; /note="Helical; Name=36"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 2468..2491; /note="Helical; Name=37"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7"; TRANSMEM 2740..2760; /note="Helical; Name=38"; /evidence="ECO:0000269|PubMed:31435011, ECO:0007744|PDB:6KG7
uniprot
proteins