SLC13A2
entrez
9058
canonical
uniprot
Q13183
canonical
ensembl
ENSG00000007216
resolver
ensp
ENSP00000316202
resolver
ensp
ENSP00000392411
resolver
ensp
ENSP00000463421
resolver
ensp
ENSP00000525274
resolver
ensp
ENSP00000525276
resolver
ensp
ENSP00000525278
resolver
enst
ENST00000579281
resolver
genesymbol
SLC13A2
resolver
genesymbol_syn
NADC1
resolver
genesymbol_syn
SDCT1
resolver
hgnc
HGNC:10917
resolver
uniprot
B2RBI9
resolver
uniprot
B4DPL1
resolver
uniprot
E7ETH5
resolver
uniprot
J3QL78
resolver
uniprot
Q4VAR7
resolver
uniprot_entry
J3QL78_HUMAN
resolver
uniprot_entry
S13A2_HUMAN
resolver
uniprot_sec
B2RBI9
resolver
uniprot_sec
B4DPL1
resolver
uniprot_sec
E7ETH5
resolver
uniprot_sec
Q4VAR7
resolver
activity_regulation
ACTIVITY REGULATION: Li(+) decreases succinate transport in the presence of Na(+), by competing at one of the three cation binding sites (PubMed:9668069). Citrate transport is inhibited by N-(p-amylcinnamoyl) anthranilic acid (ACA) (PubMed:38552027). {ECO:0000269|PubMed:38552027, ECO:0000269|PubMed:9668069}.
uniprot
proteins
amino_acid_sequence
MATCWQALWAYRSYLIVFFVPILLLPLPILVPSKEAYCAYAIILMALFWCTEALPLAVTALFPLILFPMMGIVDASEVAVEYLKDSNLLFFGGLLVAIAVEHWNLHKRIALRVLLIVGVRPAPLILGFMLVTAFLSMWISNTATSAMMVPIAHAVLDQLHSSQASSNVEEGSNNPTFELQEPSPQKEVTKLDNGQALPVTSASSEGRAHLSQKHLHLTQCMSLCVCYSASIGGIATLTGTAPNLVLQGQINSLFPQNGNVVNFASWFSFAFPTMVILLLLAWLWLQILFLGFNFRKNFGIGEKMQEQQQAAYCVIQTEHRLLGPMTFAEKAISILFVILVLLWFTREPGFFLGWGNLAFPNAKGESMVSDGTVAIFIGIIMFIIPSKFPGLTQDPENPGKLKAPLGLLDWKTVNQKMPWNIVLLLGGGYALAKGSERSGLSEWLGNKLTPLQSVPAPAIAIILSLLVATFTECTSNVATTTIFLPILASMAQAICLHPLYVMLPCTLATSLAFMLPVATPPNAIVFSFGDLKVLDMARAGFLLNIIGVLIIALAINSWGIPLFSLHSFPSWAQSNTTAQCLPSLANTTTPSP
uniprot
proteins
function
FUNCTION: Low-affinity sodium-dicarboxylate cotransporter, that mediates the entry of citric acid cycle intermediates, such as succinate, citrate, fumarate and alpha-ketoglutarate (2-oxoglutarate) into the small intestine and renal proximal tubule (PubMed:10894787, PubMed:8967342, PubMed:9668069, PubMed:38552027). Transports the dicarboxylate into the cell with a probable stoichiometry of 3 Na(+) for 1 divalent dicarboxylate, rendering the process electrogenic (PubMed:10894787, PubMed:8967342, PubMed:9668069). Citrate is transported in protonated form as a divalent anion, rather than the trivalent form which is normally found in blood (PubMed:10894787). Has a critical role in renal dicarboxylate transport (By similarity). {ECO:0000250|UniProtKB:Q9ES88, ECO:0000269|PubMed:10894787, ECO:0000269|PubMed:38552027, ECO:0000269|PubMed:8967342, ECO:0000269|PubMed:9668069}.
uniprot
proteins
mass_dalton
64410
uniprot
proteins
mutagenesis
MUTAGEN 140; /note="S->A: Decreased citrate transporter activity."; /evidence="ECO:0000269|PubMed:38552027"; MUTAGEN 141; /note="N->A: Decreased citrate transporter activity."; /evidence="ECO:0000269|PubMed:38552027"; MUTAGEN 142; /note="T->A: Decreased citrate transporter activity."; /evidence="ECO:0000269|PubMed:38552027"; MUTAGEN 476; /note="N->A: Decreased citrate transporter activity."; /evidence="ECO:0000269|PubMed:38552027
uniprot
proteins
protein_family
NADC subfamily
uniprot
proteins
protein_family
SLC13A/DASS transporter (TC 2.A.47) family
uniprot
proteins
pubmed
10894787
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17470169
uniprot
proteins
pubmed
27927654
uniprot
proteins
pubmed
38552027
uniprot
proteins
pubmed
8967342
uniprot
proteins
pubmed
9668069
uniprot
proteins
sequence_length
592
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:27927654}; Multi-pass membrane protein {ECO:0000269|PubMed:38552027}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..28; /note="Helical"; /evidence="ECO:0000269|PubMed:38552027, ECO:0007744|PDB:8W6C, ECO:0007744|PDB:8W6D"; TRANSMEM 37..53; /note="Helical"; /evidence="ECO:0000269|PubMed:38552027, ECO:0007744|PDB:8W6C, ECO:0007744|PDB:8W6D"; TRANSMEM 55..69; /note="Helical"; /evidence="ECO:0000269|PubMed:38552027, ECO:0007744|PDB:8W6C, ECO:0007744|PDB:8W6D"; TRANSMEM 75..96; /note="Helical"; /evidence="ECO:0000269|PubMed:38552027, ECO:0007744|PDB:8W6C, ECO:0007744|PDB:8W6D"; TRANSMEM 125..138; /note="Helical"; /evidence="ECO:0000269|PubMed:38552027, ECO:0007744|PDB:8W6C, ECO:0007744|PDB:8W6D"; TRANSMEM 140..151; /note="Helical"; /evidence="ECO:0000269|PubMed:38552027, ECO:0007744|PDB:8W6C, ECO:0007744|PDB:8W6D"; TRANSMEM 219..235; /note="Helical"; /evidence="ECO:0000269|PubMed:38552027, ECO:0007744|PDB:8W6C, ECO:0007744|PDB:8W6D"; TRANSMEM 270..287; /note="Helical"; /evidence="ECO:0000269|PubMed:38552027, ECO:0007744|PDB:8W6C, ECO:0007744|PDB:8W6D"; TRANSMEM 331..347; /note="Helical"; /evidence="ECO:0000269|PubMed:38552027, ECO:0007744|PDB:8W6C, ECO:0007744|PDB:8W6D"; TRANSMEM 368..383; /note="Helical"; /evidence="ECO:0000269|PubMed:38552027, ECO:0007744|PDB:8W6C, ECO:0007744|PDB:8W6D"; TRANSMEM 417..433; /note="Helical"; /evidence="ECO:0000269|PubMed:38552027, ECO:0007744|PDB:8W6C, ECO:0007744|PDB:8W6D"; TRANSMEM 507..526; /note="Helical"; /evidence="ECO:0000269|PubMed:38552027, ECO:0007744|PDB:8W6C, ECO:0007744|PDB:8W6D"; TRANSMEM 531..553; /note="Helical"; /evidence="ECO:0000269|PubMed:38552027, ECO:0007744|PDB:8W6C, ECO:0007744|PDB:8W6D
uniprot
proteins