Jam2
entrez
67374
canonical
uniprot
Q9JI59
canonical
ensembl
ENSMUSG00000053062
resolver
ensp
ENSMUSP00000109833
resolver
ensp
ENSMUSP00000156235
resolver
enst
ENSMUST00000114195
resolver
genesymbol
Jam2
resolver
genesymbol_syn
Vejam
resolver
uniprot
A6X955
resolver
uniprot
Q8C5K9
resolver
uniprot
Q8CE95
resolver
uniprot_entry
JAM2_MOUSE
resolver
uniprot_sec
A6X955
resolver
uniprot_sec
Q8C5K9
resolver
uniprot_sec
Q8CE95
resolver
amino_acid_sequence
MARSPQGLLMLLLLHYLIVALDYHKANGFSASKDHRQEVTVIEFQEAILACKTPKKTTSSRLEWKKVGQGVSLVYYQQALQGDFKDRAEMIDFNIRIKNVTRSDAGEYRCEVSAPTEQGQNLQEDKVMLEVLVAPAVPACEVPTSVMTGSVVELRCQDKEGNPAPEYIWFKDGTSLLGNPKGGTHNNSSYTMNTKSGILQFNMISKMDSGEYYCEARNSVGHRRCPGKRMQVDVLNISGIIATVVVVAFVISVCGLGTCYAQRKGYFSKETSFQKGSPASKVTTMSENDFKHTKSFII
uniprot
proteins
function
FUNCTION: Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM3 to regulate different cellular processes (PubMed:16093349, PubMed:21868569, PubMed:24357068). Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow (PubMed:21868569, PubMed:24357068). At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (PubMed:21868569, PubMed:24357068). Plays a central role in leukocytes extravasation by facilitating not only transmigration but also tethering and rolling of leukocytes along the endothelium (PubMed:16297198, PubMed:19740376). Tethering and rolling of leukocytes are dependent on the binding by JAM2 of the integrin alpha-4/beta-1 (PubMed:19740376). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (Probable). Also functions as an inhibitory somatodendritic cue that prevents the myelination of non-axonal parts of neurons (PubMed:27499083). During myogenesis, it is involved in myocyte fusion (By similarity). May also play a role in angiogenesis (PubMed:25911611). {ECO:0000250|UniProtKB:A0A0R4IGV4, ECO:0000269|PubMed:16093349, ECO:0000269|PubMed:16297198, ECO:0000269|PubMed:19740376, ECO:0000269|PubMed:21868569, ECO:0000269|PubMed:24357068, ECO:0000269|PubMed:25911611, ECO:0000269|PubMed:27499083, ECO:0000305|PubMed:15372036, ECO:0000305|PubMed:25817991}.
uniprot
proteins
mass_dalton
33047
uniprot
proteins
post_translational_modification
PTM: The expression in Sertoli cells is regulated by TGFB3 through ubiquitin-mediated proteasomal degradation. {ECO:0000269|PubMed:25817991}.
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
10779521
uniprot
proteins
pubmed
11036763
uniprot
proteins
pubmed
12810109
uniprot
proteins
pubmed
15372036
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16093349
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16297198
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19740376
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21868569
uniprot
proteins
pubmed
24357068
uniprot
proteins
pubmed
25817991
uniprot
proteins
pubmed
25911611
uniprot
proteins
pubmed
27499083
uniprot
proteins
pubmed
32142645
uniprot
proteins
sequence_length
298
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11036763, ECO:0000269|PubMed:25817991}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P57087}. Cell junction {ECO:0000269|PubMed:16093349, ECO:0000269|PubMed:25817991}. Cell junction, tight junction {ECO:0000269|PubMed:11036763, ECO:0000269|PubMed:15372036}. Note=Localized at tight junctions of both epithelial, endothelial cells and Sertoli cells (PubMed:11036763). Specifically localized within the somatodendritic compartment of neurons and excluded from the axon (PubMed:27499083). {ECO:0000269|PubMed:11036763, ECO:0000269|PubMed:27499083}.
uniprot
proteins
transmembrane_region
TRANSMEM 237..257; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins