Creb3l2
entrez
208647
canonical
uniprot
Q8BH52
canonical
ensembl
ENSMUSG00000038648
resolver
ensp
ENSMUSP00000040208
resolver
enst
ENSMUST00000041093
resolver
genesymbol
Creb3l2
resolver
genesymbol_syn
Bbf2h7
resolver
uniprot
B2RRL0
resolver
uniprot
Q8CB61
resolver
uniprot
Q8CBN2
resolver
uniprot_entry
CR3L2_MOUSE
resolver
uniprot_sec
B2RRL0
resolver
uniprot_sec
Q8CB61
resolver
uniprot_sec
Q8CBN2
resolver
amino_acid_sequence
MEVLESGEQSVLQWDRKLSELSEPGETEALMYHTHFSELLDEFSQNVLGQLLSDPFLSEKSESMEVEPSPTSPAPLIQAEHSYSLSEEPRTQSPFTHAATSDSFNDEEVESEKWYLSTEFPSATIKTEPITEEQPPGLVPSVTLTITAISTPFEKEESPLDMNAGGDSSCQTLIPKIKLEPHEVDQFLNFSPKEASVDQLHLPPTPPSSHSSDSEGSLSPNPRLHPFSLSQAHSPARAMPRGPSALSTSPLLTAPHKLQGSGPLVLTEEEKRTLVAEGYPIPTKLPLTKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRKKVEVLENTNRTLLQQLQKLQTLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGSFFQGYGPYPSATKMALPSQHPLSEPYTASVVRSRNLLIYEEHAPLEESSSPASAGELGGWDRGSSLLRASSGLEALPEVDLPHFLISNETSLEKSVLLELQQHLVSSKLEGNETLKVVELERRVNATF
uniprot
proteins
function
FUNCTION: Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (PubMed:19767744). In a neuroblastoma cell line, protects cells from ER stress-induced death (PubMed:17178827). In vitro activates transcription of target genes via direct binding to the CRE site (PubMed:17178827). {ECO:0000269|PubMed:17178827, ECO:0000269|PubMed:19767744}.
uniprot
proteins
mass_dalton
57469
uniprot
proteins
mutagenesis
MUTAGEN 427; /note="R->A: Loss of S1P cleavage."; /evidence="ECO:0000269|PubMed:17178827"; MUTAGEN 427; /note="R->A: Loss of S1P cleavage; when associated with V-430."; /evidence="ECO:0000269|PubMed:17178827"; MUTAGEN 430; /note="L->V: Loss of S1P cleavage."; /evidence="ECO:0000269|PubMed:17178827"; MUTAGEN 430; /note="L->V: Loss of S1P cleavage; when associated with A-427."; /evidence="ECO:0000269|PubMed:17178827
uniprot
proteins
post_translational_modification
PTM: Upon ER stress, translocated to the Golgi apparatus, where it is processed by regulated intramembrane proteolysis (RIP) to release the cytosol-facing N-terminal transcription factor domain. The cleavage is performed sequentially by site-1 and site-2 proteases (S1P/MBTPS1 and S2P/MBTPS2). {ECO:0000269|PubMed:17178827}.; PTM: N-glycosylated. {ECO:0000269|PubMed:17178827}.; PTM: Ubiquitinated by HRD1/SYVN1; undergoes 'Lys-48'-linked ubiquitination, followed by rapid proteasomal degradation under normal conditions. Upon ER stress, SYVN1 E3 ubiquitin-protein ligase dissociates from its substrate, ubiquitination does not occur and CREB3L2 is stabilized. {ECO:0000269|PubMed:22705851}.
uniprot
proteins
protein_family
ATF subfamily
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17178827
uniprot
proteins
pubmed
19767744
uniprot
proteins
pubmed
22705851
uniprot
proteins
sequence_length
521
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17178827}; Single-pass type II membrane protein. Note=ER membrane resident protein. Upon ER stress, translocated to the Golgi apparatus where it is cleaved. The cytosolic N-terminal fragment (processed cyclic AMP-responsive element-binding protein 3-like protein 1) is transported into the nucleus. {ECO:0000269|PubMed:17178827}.; SUBCELLULAR LOCATION: [Processed cyclic AMP-responsive element-binding protein 3-like protein 2]: Nucleus {ECO:0000269|PubMed:17178827}. Note=Upon ER stress, translocated into the nucleus. {ECO:0000269|PubMed:17178827}.
uniprot
proteins
transmembrane_region
TRANSMEM 379..399; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins