MBLAC1
entrez
255374
canonical
uniprot
A4D2B0
canonical
ensembl
ENSG00000214309
resolver
ensp
ENSP00000381150
resolver
ensp
ENSP00000575307
resolver
enst
ENST00000398075
resolver
enst
ENST00000905248
resolver
genesymbol
MBLAC1
resolver
hgnc
HGNC:22180
resolver
uniprot
Q8N5X8
resolver
uniprot_entry
MBLC1_HUMAN
resolver
uniprot_sec
Q8N5X8
resolver
amino_acid_sequence
MRTEPLCGASPLLVPGDPYSVVVLLQGYAEPEGVGDAVRADGSVTLVLPQTRGPASSHRESPRGSGGAEAALEEAARGPILVDTGGPWAREALLGALAGQGVAPGDVTLVVGTHGHSDHIGNLGLFPGAALLVSHDFCLPGGRYLPHGLGEGQPLRLGPGLEVWATPGHGGQRDVSVVVAGTALGTVVVAGDVFERDGDEDSWQALSEDPAAQERSRKRVLVVADVVVPGHGPPFRVLREASQPETEGGGNSQQEPVVGDEEPALH
uniprot
proteins
ec_number
3.1.27.-
uniprot
proteins
function
FUNCTION: Endoribonuclease that catalyzes the hydrolysis of histone-coding pre-mRNA 3'-end. Involved in histone pre-mRNA processing during the S-phase of the cell cycle, which is required for entering/progressing through S-phase (PubMed:30507380). Cleaves histone pre-mRNA at a major and a minor cleavage site after the 5'-ACCCA-3' and the 5'-ACCCACA-3' sequence, respectively, and located downstream of the stem-loop (PubMed:30507380). May require the presence of the HDE element located at the histone pre-RNA 3'-end to avoid non-specific cleavage (PubMed:30507380). {ECO:0000269|PubMed:30507380}.
uniprot
proteins
mass_dalton
27202
uniprot
proteins
mutagenesis
MUTAGEN 169; /note="H->A: Loss of endoribonuclease activity; when associated with A-192 and A-231."; /evidence="ECO:0000269|PubMed:30507380"; MUTAGEN 192; /note="D->A: Loss of endoribonuclease activity; when associated with A-169 and A-231."; /evidence="ECO:0000269|PubMed:30507380"; MUTAGEN 231; /note="H->A: Loss of endoribonuclease activity; when associated with A-169 and A-192."; /evidence="ECO:0000269|PubMed:30507380
uniprot
proteins
protein_family
Glyoxalase II family
uniprot
proteins
protein_family
Metallo-beta-lactamase superfamily
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
30507380
uniprot
proteins
sequence_length
266
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:30507380}. Nucleus {ECO:0000269|PubMed:30507380}. Note=Localizes in the nucleus during early S-phase of the cell cycle. {ECO:0000269|PubMed:30507380}.
uniprot
proteins