Kcnk6
entrez
52150
canonical
uniprot
Q3TBV4
canonical
ensembl
ENSMUSG00000046410
resolver
ensp
ENSMUSP00000082975
resolver
enst
ENSMUST00000085818
resolver
genesymbol
Kcnk6
resolver
uniprot
Q3TQ68
resolver
uniprot
Q3V1G1
resolver
uniprot_entry
KCNK6_MOUSE
resolver
uniprot_entry
Q3TQ68_MOUSE
resolver
uniprot_entry
Q3V1G1_MOUSE
resolver
amino_acid_sequence
MRRGALLASALAAYAGYLALGALLVARLERPHEARLRAELGTLREQLLQHSPCVAAHALDAFVERVLAAGRLGRAALANASGAANASDPAWDFASALFFASTLVTTVGYGYTTPLTDAGKAFSIVFALLGVPITMLLLTASAQRLSLLLTHAPLSWLSLHWGWPPQRAARWHLVALLMVIVAIFFLVPAAVFAYLEEAWSFLDAFYFCFISLSTIGLGDYVPGEAPGQPYRALYKVLVTAYLFLGLVAMVLVLQTFRRVSDLHGLTELILLPDPDPASLSQDEDDQVAVLDARTDLHQHLSAASHADYASIPR
uniprot
proteins
function
FUNCTION: K(+) channel that conducts outward rectifying currents at the membranes of the endolysosomal system (PubMed:28381826, PubMed:29958799). Active in lysosomes where it regulates lysosome numbers and size (PubMed:28381826). In macrophages, enables K(+) efflux coupled to ATP-induced NLRP3 inflammasome activation upon bacterial infection. Cooperates with ATP-gated P2RX7 to activate NLRP3 inflammasome, with P2RX7 conducting Ca(2+) and Na(+) influx that sets the membrane potential for K(+) efflux (PubMed:29958799). {ECO:0000269|PubMed:28381826, ECO:0000269|PubMed:29958799}.
uniprot
proteins
mass_dalton
33807
uniprot
proteins
post_translational_modification
PTM: N-glycosylation is necessary for targeting to lysosomes. {ECO:0000250|UniProtKB:G3V8R8}.
uniprot
proteins
protein_family
Two pore domain potassium channel (TC 1.A.1.8) family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16354767
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
28381826
uniprot
proteins
pubmed
29958799
uniprot
proteins
sequence_length
313
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000269|PubMed:28381826}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9Y257}. Lysosome membrane {ECO:0000269|PubMed:28381826}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9Y257}.
uniprot
proteins
transmembrane_region
TRANSMEM 5..25; /note="Helical; Name=M1"; /evidence="ECO:0000250|UniProtKB:Q9Y257"; TRANSMEM 121..141; /note="Helical; Name=M2"; /evidence="ECO:0000250|UniProtKB:Q9Y257"; TRANSMEM 173..193; /note="Helical; Name=M3"; /evidence="ECO:0000250|UniProtKB:Q9Y257"; TRANSMEM 236..256; /note="Helical; Name=M4"; /evidence="ECO:0000250|UniProtKB:Q9Y257
uniprot
proteins