Agap2
entrez
65218
canonical
uniprot
Q8CGU4
canonical
ensembl
ENSRNOG00000025584
resolver
ensembl
ENSRNOG00055026616
resolver
ensembl
ENSRNOG00060008102
resolver
ensembl
ENSRNOG00065016155
resolver
ensp
ENSRNOP00000069597
resolver
ensp
ENSRNOP00000093674
resolver
ensp
ENSRNOP00000109311
resolver
ensp
ENSRNOP00055037688
resolver
ensp
ENSRNOP00060010207
resolver
ensp
ENSRNOP00065021138
resolver
enst
ENSRNOT00000084012
resolver
enst
ENSRNOT00000117693
resolver
enst
ENSRNOT00055045958
resolver
enst
ENSRNOT00060013414
resolver
enst
ENSRNOT00065026895
resolver
genesymbol
Agap2
resolver
genesymbol_syn
Centg1
resolver
uniprot
A0A0G2JVS4
resolver
uniprot
A0A8I6AM98
resolver
uniprot
Q9JHW8
resolver
uniprot_entry
A0A0G2JVS4_RAT
resolver
uniprot_entry
A0A8I6AM98_RAT
resolver
uniprot_entry
AGAP2_RAT
resolver
uniprot_sec
Q9JHW8
resolver
activity_regulation
ACTIVITY REGULATION: GAP activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and, to a lesser extent, by phosphatidylinositol 3,4,5-trisphosphate (PIP3). Phosphatidic acid potentiates PIP2 stimulation (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MSRGAGALQRRTTTYLISLTLVKLESVPPPPPSPSAAAVGAPGARGSEPRDPGSPRGAEEPGKKRHERLFHRQDALWISTSSAGAGGAEPPALSPAPASPARPVSPAPGRRLSLWAAPPGPPLSGGLSPDSKPGGAPSSSRRPLLSSPSWGGPEPEGRTGGGVPGSSSPHPGTGSRRLKVAPPPPAPKPFKTVTTSGAKAGGGKGAGSRLSWPESEGKPRVKGSKSTAGTGASAVAAGGGGSAAVTTSGGVGAGAGARGKLSPRKGKSKTLDNSDLHPGPSAGSPPLTVPAIPVPATSVTAASTQPLGPAPPITLEPPAPGLKRGREGGRASTRDRKMLKFISGIFTKSTGGPPGPGPLPGPQGLSSSSGSRELLGAELRASPKAVVNSQEWTLSRSIPELRLGVLGDVRSGKSSLIHRFLTGSYQVLEKPESEQYKKEMLVDGQTHLVLIREEAGAPDAKFSGWADAVIFVFSLEDESSFQAVSHLHGQLISLRGEGRGGLALALVGTQDRISASSPRVVGDARARALCTDMKRCSYYETCATYGLNVDRVFQEVAQKVVTLRKQQQLLAACKSLPSSPSHSAASTPVAGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGSLHRAAKRRTSLFANRRGSDSEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGPSASINGLVKDMSTVQMGEGPEASTPMPSPSPSPSSLQLPTDQTSKHLLKPDRNLARALSTDCTPSGDLSPLSREPPPSPMVKKQRRKKLSTPSKTEGSAVQAEAKRKMWKLKSFGSLRNIYKAEENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSTCVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAKPTRDSSREERESWIRAKYEQLLFLAPLGTTEEPLGRQLWAAVEAQDVAAVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGEGGSTATTPSAATTPSITATPSPRRRSSAASLGRVDTTIALV
uniprot
proteins
function
FUNCTION: GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. Aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. {ECO:0000269|PubMed:11136977, ECO:0000269|PubMed:11823862, ECO:0000269|PubMed:15385964, ECO:0000269|PubMed:16263930}.
uniprot
proteins
mass_dalton
124438
uniprot
proteins
mutagenesis
MUTAGEN 187; /note="P->L: Abolishes interactions with HOMER1C and NF2."; /evidence="ECO:0000269|PubMed:14528310, ECO:0000269|PubMed:15598747"; MUTAGEN 414; /note="S->N: Fails to activate PI3 kinase."; /evidence="ECO:0000269|PubMed:11136977"; MUTAGEN 679; /note="K->N: Abolishes phospholipid binding and nuclear localization; when associated with N-687."; /evidence="ECO:0000269|PubMed:16263930"; MUTAGEN 687; /note="K->N: Abolishes phospholipid binding and nuclear localization; when associated with N-679."; /evidence="ECO:0000269|PubMed:16263930
uniprot
proteins
protein_family
Centaurin gamma-like family
uniprot
proteins
pubmed
11136977
uniprot
proteins
pubmed
11823862
uniprot
proteins
pubmed
14528310
uniprot
proteins
pubmed
15385964
uniprot
proteins
pubmed
15598747
uniprot
proteins
pubmed
16263930
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
1186
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
uniprot
proteins