P0C152
uniprot
P0C152
canonical
amino_acid_sequence
MVMRTRPLAAMAVRSCFSALTGTVYLLLVLCEVSWAQIFSFPFQRPETCDLNQYFDISALSCAPCGANQRRDALGTSCICLPGYHMISNNGGPSIICKKCPENMKGVTKDGWDCISCPNGLTAEGKCHCPSGHILVERNVSGSLLSQATCELCDGNENSFTKPNALGTRCVRCEPTFVNTSRSCSCSEPHISTGGLCFSNTGNFPQRLISTERYGELGMSSNSEWFTKYLQATAAACWTHSNLTSCQALGNMCVMNMNSYDSTTFDACRLFHYVFEGAAGLTGVHSVPFWRQNLPWLFYGDQPGLASQVLSTTPLPTNFSFKGQNQLKFVAASYDIRGNFIRWQTVKGGVLQLCPDTERRLDAAYSFGTTYQQNCEISLSKLLADFPSPVFYDIYLEYTDEVQHHYLWAIPVLNLNLQHNKLFVNQDSSSSKWLLTRRIFLVDAVSGRENDLGNQPRVIRVATQISLSIRLVPNTKNGNIYTPLLTIAYSDIDIKNAYSQSVKISFSVKYEMNQGDAFVQTDIALGVLGGLAVLSSLLKTAGWKRRIGSPMIDLQTVMKFLLYYAGDLANVFFIITVGTGLYWLIFFKAQKSVSVLLPMPVQEERFVTYVGCAFAMKALQFLHKLISQITIDIFFIDWERPKGKVLKAVEGEGGVRSATVPVSIWRTYFVANEWNEIQTVRKINPLFQVLTTLFFLEVVGFKNLALMDPSSSLSRSLSDYAAPYSRILRYAVATTIWLVIGIVQVVFFAAFYERFIEDKIRQFVDLCSMSNVSVFLLSHRCFGYYIHGRSVHGHADTNMEDMNMNLRREAENLCSQRGLVPNTDGQTFQIAVSSQMRQHYDRIHETLTRRNGPARLLSSSGSTLEQSIKAYHAMNKFLGSFIDHVHKEMDYFIKDKLLLEKILGMEFMEPLEKSIFYNDESHSFSSVLYYGNEATLLIFDLLFFCVVDLACQNFVLASFLTYLQQEIFRFIRNTVGQKNLATKTLVDERFLI
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Tmem67 are the cause of Wistar polycystic kidney (wpk). Homozygous wkp rats develop nephromegaly, hypertension, proteinuria, impaired urine-concentrating capacity, and uremia, resulting in death at 4 week of age. Early cysts are present in the nephrogenic zone at embryonic day 19. {ECO:0000269|PubMed:16415887}.
uniprot
proteins
function
FUNCTION: Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Is a key regulator of stereociliary bundle orientation. Required for epithelial cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (sftpc) (By similarity). Involved in the negative regulation of canonical Wnt signaling, and activation of the non-canonical cascade stimulated by WNT5A (By similarity). In non-canonical Wnt signaling, it may act as ROR2 coreceptor (By similarity). {ECO:0000250|UniProtKB:Q8BR76, ECO:0000269|PubMed:19515853, ECO:0000269|PubMed:19815549}.
uniprot
proteins
mass_dalton
111740
uniprot
proteins
pubmed
11095650
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
16415887
uniprot
proteins
pubmed
19515853
uniprot
proteins
pubmed
19815549
uniprot
proteins
sequence_length
992
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5HYA8}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:19815549}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q5HYA8}. Note=Localizes at the transition zone, a region between the basal body and the ciliary axoneme. {ECO:0000250|UniProtKB:Q5HYA8}.
uniprot
proteins
transmembrane_region
TRANSMEM 517..545; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q5HYA8"; TRANSMEM 556..587; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q5HYA8"; TRANSMEM 601..628; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q5HYA8"; TRANSMEM 668..698; /note="Discontinuously helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q5HYA8"; TRANSMEM 729..768; /note="Discontinuously helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q5HYA8"; TRANSMEM 924..949; /note="Discontinuously helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q5HYA8"; TRANSMEM 955..982; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q5HYA8
uniprot
proteins