ATAT1
entrez
79969
canonical
uniprot
Q5SQI0
canonical
ensembl
ENSG00000137343
resolver
ensembl
ENSG00000206488
resolver
ensembl
ENSG00000223752
resolver
ensembl
ENSG00000229061
resolver
ensembl
ENSG00000231257
resolver
ensembl
ENSG00000234549
resolver
ensembl
ENSG00000235658
resolver
ensp
ENSP00000324222
resolver
ensp
ENSP00000324459
resolver
ensp
ENSP00000327832
resolver
ensp
ENSP00000332374
resolver
ensp
ENSP00000365666
resolver
ensp
ENSP00000365668
resolver
genesymbol
ATAT1
resolver
genesymbol_syn
C6orf134
resolver
genesymbol_syn
MEC17
resolver
hgnc
HGNC:21186
resolver
uniprot
A2AB28
resolver
uniprot
B7Z4Q7
resolver
uniprot
Q3LIB0
resolver
uniprot
Q5JP39
resolver
uniprot
Q5JP40
resolver
uniprot
Q5JP42
resolver
uniprot
Q5SQI1
resolver
uniprot
Q5SU03
resolver
uniprot
Q86X42
resolver
uniprot
Q8NDK9
resolver
uniprot
Q9BRS1
resolver
uniprot
Q9H8X5
resolver
uniprot_entry
ATAT_HUMAN
resolver
uniprot_entry
B7Z4Q7_HUMAN
resolver
uniprot_sec
A2AB28
resolver
uniprot_sec
Q3LIB0
resolver
uniprot_sec
Q5JP39
resolver
uniprot_sec
Q5JP40
resolver
uniprot_sec
Q5JP42
resolver
uniprot_sec
Q5SQI1
resolver
uniprot_sec
Q5SU03
resolver
uniprot_sec
Q86X42
resolver
uniprot_sec
Q8NDK9
resolver
uniprot_sec
Q9BRS1
resolver
uniprot_sec
Q9H8X5
resolver
amino_acid_sequence
MEFPFDVDALFPERITVLDQHLRPPARRPGTTTPARVDLQQQIMTIIDELGKASAKAQNLSAPITSASRMQSNRHVVYILKDSSARPAGKGAIIGFIKVGYKKLFVLDDREAHNEVEPLCILDFYIHESVQRHGHGRELFQYMLQKERVEPHQLAIDRPSQKLLKFLNKHYNLETTVPQVNNFVIFEGFFAHQHRPPAPSLRATRHSRAAAVDPTPAAPARKLPPKRAEGDIKPYSSSDREFLKVAVEPPWPLNRAPRRATPPAHPPPRSSSLGNSPERGPLRPFVPEQELLRSLRLCPPHPTARLLLAADPGGSPAQRRRTRGTPPGLVAQSCCYSRHGGVNSSSPNTGNQDSKQGEQETKNRSASEEQALSQDGSGEKPMHTAPPQAPAPPAQSWTVGGDILNARFIRNLQERRSTRPW
uniprot
proteins
ec_number
2.3.1.108
uniprot
proteins
function
FUNCTION: Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly. {ECO:0000255|HAMAP-Rule:MF_03130, ECO:0000269|PubMed:20829795, ECO:0000269|PubMed:21068373, ECO:0000269|PubMed:24097348, ECO:0000269|PubMed:24906155}.
uniprot
proteins
mass_dalton
46810
uniprot
proteins
mutagenesis
MUTAGEN 58; /note="Q->A: Loss of acetyltransferase activity."; /evidence="ECO:0000269|PubMed:23071318"; MUTAGEN 61; /note="S->A: No effect on catalytic activity."; /evidence="ECO:0000269|PubMed:23071318"; MUTAGEN 64; /note="I->A: Strong reduction in acetyltransferase activity."; /evidence="ECO:0000269|PubMed:23071314, ECO:0000269|PubMed:23071318, ECO:0000269|PubMed:24906155"; MUTAGEN 69; /note="R->A: Strong reduction in acetyltransferase activity."; /evidence="ECO:0000269|PubMed:23071314"; MUTAGEN 102; /note="K->A: Strong reduction in acetyltransferase activity."; /evidence="ECO:0000269|PubMed:24906155"; MUTAGEN 105; /note="F->A: Reduced activity."; /evidence="ECO:0000269|PubMed:23071314"; MUTAGEN 106; /note="V->A: Reduced activity."; /evidence="ECO:0000269|PubMed:23071314"; MUTAGEN 107; /note="L->A: Reduced activity."; /evidence="ECO:0000269|PubMed:23071314"; MUTAGEN 108; /note="D->A: Reduced activity."; /evidence="ECO:0000269|PubMed:23071314"; MUTAGEN 109; /note="D->A: Slight increase in activity."; /evidence="ECO:0000269|PubMed:23071314"; MUTAGEN 109; /note="D->R: Marginal increase in activity."; /evidence="ECO:0000269|PubMed:23071314"; MUTAGEN 111; /note="E->A: 2-fold increase in activity."; /evidence="ECO:0000269|PubMed:23071314"; MUTAGEN 111; /note="E->R: No effect on catalytic activity."; /evidence="ECO:0000269|PubMed:23071314"; MUTAGEN 115; /note="E->A: Reduced activity."; /evidence="ECO:0000269|PubMed:23071314"; MUTAGEN 117; /note="E->A: Reduced activity."; /evidence="ECO:0000269|PubMed:23071314"; MUTAGEN 120; /note="C->A,S: Strong reduction in microtubule acetylation."; /evidence="ECO:0000269|PubMed:23071314"; MUTAGEN 157; /note="D->E,N: Strong reduction in microtubule acetylation."; /evidence="ECO:0000269|PubMed:21068373, ECO:0000269|PubMed:23071314"; MUTAGEN 158; /note="R->A: 20% of wild-type acetyltransferase activity."; /evidence="ECO:0000269|PubMed:23071318, ECO:0000269|PubMed:24906155"; MUTAGEN 182; /note="N->A: Strong reduction in activity."; /evidence="ECO:0000269|PubMed:23071314"; MUTAGEN 183; /note="F->A: Strong reduction in activity."; /evidence="ECO:0000269|PubMed:23071314
uniprot
proteins
post_translational_modification
PTM: Autoacetylation strongly increases tubulin acetylation. {ECO:0000255|HAMAP-Rule:MF_03130}.
uniprot
proteins
protein_family
Acetyltransferase ATAT1 family
uniprot
proteins
pubmed
12880961
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
20829795
uniprot
proteins
pubmed
21068373
uniprot
proteins
pubmed
23071314
uniprot
proteins
pubmed
23071318
uniprot
proteins
pubmed
23110214
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24097348
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24906155
uniprot
proteins
sequence_length
421
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03130, ECO:0000269|PubMed:24097348}. Membrane, clathrin-coated pit {ECO:0000255|HAMAP-Rule:MF_03130, ECO:0000269|PubMed:24097348}. Cell junction, focal adhesion {ECO:0000255|HAMAP-Rule:MF_03130, ECO:0000269|PubMed:24097348}. Cell projection, axon {ECO:0000255|HAMAP-Rule:MF_03130}. Cytoplasm, cytoskeleton {ECO:0000255|HAMAP-Rule:MF_03130}. Cytoplasm, cytoskeleton, spindle {ECO:0000255|HAMAP-Rule:MF_03130}.
uniprot
proteins