Rnf169
entrez
108937
canonical
uniprot
E9Q7F2
canonical
ensembl
ENSMUSG00000058761
resolver
ensp
ENSMUSP00000079631
resolver
ensp
ENSMUSP00000266075
resolver
enst
ENSMUST00000080817
resolver
genesymbol
Rnf169
resolver
genesymbol_syn
Kiaa1991
resolver
uniprot
Q69Z47
resolver
uniprot_entry
RN169_MOUSE
resolver
uniprot_sec
Q69Z47
resolver
amino_acid_sequence
MAAAGPSTRASSAAAAAALSRRGRRGRCDEMAAAKAGAPGPASSPALLVLRSAPRPEESGCTGCLETPGEVAALPCSHSRCRGCASRAAGPGCRRCRPRGSGWARRRARDDGQAAAELMGERARRGQPEPCRPRRDGGAAASGPRPEPEPLAEPEFIFRTPIKLSKPGELSEEYGCLRKLRGEKLQEEKDCDDQIHKLLQEDSEMGKRKADEQKKRDEAVVLKTSLEQCPARLSDSENEEPSRGQMMQTHRSAFVSKNSSCSLAFLAGKLNTKVQRSQSCSDTVQDRVRSRLRTAPPNRAKITTITPGSTPIIGVLLSTQNNRCLSAPDLTIEKRLPFGSLSSLASLHKPERSISPESNDSISEELNHFKPIVCSPCTPPKRLPDGRVLSPLIIKSTPRNLTRSLQKQTSYEASPRILKKWEQIFQERQIKKTLSKATLTSLAPEAGEEFPGSDTIHSSKERPSLAFNTRLSRVQVLSECAGPTSTALECFPSVNQTKVEQDCVRKRSREFSLETCHSSEHGGASSGPSLEREQCEESGSTVDATLVKTCISTVMKTAAVNSLLPKNDVLGGVLKTKQQLKTLNHFDLGNGILVNSLGEEPIPSLRRGRKRRCKTKHLEQNGVKKLRPPSSDMDLAPKDPGLLEVGRKLQQEEEDQQLALQSHRMFDSERRTMSRRKGSVDQYLLRSSSLAGAK
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Probable E3 ubiquitin-protein ligase that acts as a regulator of double-strand breaks (DSBs) repair following DNA damage. Functions in a non-canonical fashion to harness RNF168-mediated protein recruitment to DSB-containing chromatin, thereby contributing to regulation of DSB repair pathway utilization. Once recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168, competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby favouring homologous recombination repair (HRR) and single-strand annealing (SSA) instead of non-homologous end joining (NHEJ) mediated by TP53BP1. E3 ubiquitin-protein ligase activity is not required for regulation of DSBs repair. {ECO:0000250|UniProtKB:Q8NCN4}.
uniprot
proteins
mass_dalton
75796
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by DYRK1A; phosphorylation increases RNF169 ability to block accumulation of TP53BP1 at the DSB sites. {ECO:0000250|UniProtKB:Q8NCN4}.
uniprot
proteins
protein_family
RNF169 family
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
694
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q8NCN4}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q8NCN4}. Note=Localizes to sites of double-strand breaks (DSBs) following DNA damage. Recruited to DSBs via recognition of RNF168-dependent ubiquitin products. {ECO:0000250|UniProtKB:Q8NCN4}.
uniprot
proteins