CARS1
entrez
833
canonical
uniprot
P49589
canonical
ensembl
ENSG00000110619
resolver
ensembl
ENSG00000278191
resolver
ensp
ENSP00000278224
resolver
ensp
ENSP00000369897
resolver
ensp
ENSP00000380300
resolver
ensp
ENSP00000432619
resolver
ensp
ENSP00000488062
resolver
ensp
ENSP00000632779
resolver
ensp
ENSP00000655481
resolver
ensp
ENSP00000655484
resolver
ensp
ENSP00000752187
resolver
enst
ENST00000529772
resolver
enst
ENST00000633563
resolver
genesymbol
CARS1
resolver
genesymbol_syn
CARS
resolver
hgnc
HGNC:1493
resolver
uniprot
A0ACM8QGB6
resolver
uniprot
B4DKY1
resolver
uniprot
B4DPV7
resolver
uniprot
E9PPK8
resolver
uniprot
Q53XI8
resolver
uniprot
Q5HYE4
resolver
uniprot
Q9HD24
resolver
uniprot
Q9HD25
resolver
uniprot_entry
A0ACM8QGB6_HUMAN
resolver
uniprot_entry
B4DKY1_HUMAN
resolver
uniprot_entry
B4DPV7_HUMAN
resolver
uniprot_entry
SYCC_HUMAN
resolver
uniprot_sec
E9PPK8
resolver
uniprot_sec
Q53XI8
resolver
uniprot_sec
Q5HYE4
resolver
uniprot_sec
Q9HD24
resolver
uniprot_sec
Q9HD25
resolver
amino_acid_sequence
MADSSGQQGKGRRVQPQWSPPAGTQPCRLHLYNSLTRNKEVFIPQDGKKVTWYCCGPTVYDASHMGHARSYISFDILRRVLKDYFKFDVFYCMNITDIDDKIIKRARQNHLFEQYREKRPEAAQLLEDVQAALKPFSVKLNETTDPDKKQMLERIQHAVQLATEPLEKAVQSRLTGEEVNSCVEVLLEEAKDLLSDWLDSTLGCDVTDNSIFSKLPKFWEGDFHRDMEALNVLPPDVLTRVSEYVPEIVNFVQKIVDNGYGYVSNGSVYFDTAKFASSEKHSYGKLVPEAVGDQKALQEGEGDLSISADRLSEKRSPNDFALWKASKPGEPSWPCPWGKGRPGWHIECSAMAGTLLGASMDIHGGGFDLRFPHHDNELAQSEAYFENDCWVRYFLHTGHLTIAGCKMSKSLKNFITIKDALKKHSARQLRLAFLMHSWKDTLDYSSNTMESALQYEKFLNEFFLNVKDILRAPVDITGQFEKWGEEEAELNKNFYDKKTAIHKALCDNVDTRTVMEEMRALVSQCNLYMAARKAVRKRPNQALLENIALYLTHMLKIFGAVEEDSSLGFPVGGPGTSLSLEATVMPYLQVLSEFREGVRKIAREQKVPEILQLSDALRDNILPELGVRFEDHEGLPTVVKLVDRNTLLKEREEKRRVEEEKRKKKEEAARRKQEQEAAKLAKMKIPPSEMFLSETDKYSKFDENGLPTHDMEGKELSKGQAKKLKKLFEAQEKLYKEYLQMAQNGSFQ
uniprot
proteins
disease_involvement
DISEASE: Microcephaly, developmental delay, and brittle hair syndrome (MDBH) [MIM:618891]: An autosomal recessive disorder characterized by developmental delay, motor and cognitive disabilities, brittle hair and nails, failure to thrive, and short stature. {ECO:0000269|PubMed:30824121}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Note=A chromosomal aberration involving CARS is associated with inflammatory myofibroblastic tumors (IMTs). Translocation t(2;11)(p23;p15) with ALK.
uniprot
proteins
ec_number
6.1.1.16
uniprot
proteins
function
FUNCTION: Catalyzes the ATP-dependent ligation of cysteine to tRNA(Cys). {ECO:0000269|PubMed:11347887, ECO:0000269|PubMed:30824121}.
uniprot
proteins
mass_dalton
85473
uniprot
proteins
protein_family
Class-I aminoacyl-tRNA synthetase family
uniprot
proteins
pubmed
11347887
uniprot
proteins
pubmed
12112524
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
30824121
uniprot
proteins
pubmed
7987009
uniprot
proteins
sequence_length
748
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:30824121}.
uniprot
proteins