CA1
entrez
759
canonical
uniprot
P00915
canonical
ensembl
ENSG00000133742
resolver
ensp
ENSP00000392338
resolver
ensp
ENSP00000428923
resolver
ensp
ENSP00000429798
resolver
ensp
ENSP00000430543
resolver
ensp
ENSP00000430656
resolver
ensp
ENSP00000430861
resolver
ensp
ENSP00000443517
resolver
ensp
ENSP00000545518
resolver
enst
ENST00000431316
resolver
enst
ENST00000523022
resolver
enst
ENST00000523953
resolver
enst
ENST00000542576
resolver
enst
ENST00000875459
resolver
genesymbol
CA1
resolver
genesymbol
HEL-S-11
resolver
genesymbol_syn
CA1
resolver
hgnc
HGNC:1368
resolver
uniprot
V9HWE3
resolver
uniprot_entry
CAH1_HUMAN
resolver
uniprot_entry
V9HWE3_HUMAN
resolver
activity_regulation
ACTIVITY REGULATION: Activated by histamine, imidazole, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited by coumarins, sulfonamide derivatives such as acetazolamide, benzenesulfonamide and derivatives (4-carboxyethylbenzene-sulfonamide, 4-carboxyethylbenzene-sulfonamide ethyl ester, 4-(acetyl-2-aminoethyl)benzene-sulfonamide, 4-aminoethylbenzene-sulfonamide), and 'prong inhibitors' BR15, BR17, BR22 and BR30. Activated by a short exposition to Foscarnet (phosphonoformate trisodium salt), but inhibited by a long one. Esterase activity weakly reduced by cyanamide. {ECO:0000269|PubMed:16506782, ECO:0000269|PubMed:16686544, ECO:0000269|PubMed:16807956, ECO:0000269|PubMed:17127057, ECO:0000269|PubMed:17314045, ECO:0000269|PubMed:17407288, ECO:0000269|PubMed:19186056, ECO:0000269|PubMed:19206230}.
uniprot
proteins
amino_acid_sequence
MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEIINVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELHVAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNFDPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAVPMQHNNRPTQPLKGRTVRASF
uniprot
proteins
ec_number
4.2.1.1
uniprot
proteins
ec_number
4.2.1.69
uniprot
proteins
function
FUNCTION: Catalyzes the reversible hydration of carbon dioxide (PubMed:10550681, PubMed:16506782, PubMed:16686544, PubMed:16807956, PubMed:17127057, PubMed:17314045, PubMed:17407288, PubMed:19186056, PubMed:19206230, PubMed:4994926). Can hydrate cyanamide to urea (PubMed:10550681). {ECO:0000269|PubMed:10550681, ECO:0000269|PubMed:16506782, ECO:0000269|PubMed:16686544, ECO:0000269|PubMed:16807956, ECO:0000269|PubMed:17127057, ECO:0000269|PubMed:17314045, ECO:0000269|PubMed:17407288, ECO:0000269|PubMed:19186056, ECO:0000269|PubMed:19206230, ECO:0000269|PubMed:4994926}.
uniprot
proteins
mass_dalton
28870
uniprot
proteins
protein_family
Alpha-carbonic anhydrase family
uniprot
proteins
pubmed
10550681
uniprot
proteins
pubmed
12009884
uniprot
proteins
pubmed
15299369
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16506782
uniprot
proteins
pubmed
16686544
uniprot
proteins
pubmed
16807956
uniprot
proteins
pubmed
16870440
uniprot
proteins
pubmed
17127057
uniprot
proteins
pubmed
17314045
uniprot
proteins
pubmed
17407288
uniprot
proteins
pubmed
19186056
uniprot
proteins
pubmed
19206230
uniprot
proteins
pubmed
2121614
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
3104879
uniprot
proteins
pubmed
4207120
uniprot
proteins
pubmed
4217196
uniprot
proteins
pubmed
4622589
uniprot
proteins
pubmed
4625868
uniprot
proteins
pubmed
4632246
uniprot
proteins
pubmed
4994926
uniprot
proteins
pubmed
6430186
uniprot
proteins
pubmed
6781336
uniprot
proteins
pubmed
7866410
uniprot
proteins
pubmed
7932756
uniprot
proteins
pubmed
804171
uniprot
proteins
pubmed
8057362
uniprot
proteins
sequence_length
261
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:B0BNN3}.
uniprot
proteins