Rab34
entrez
360571
canonical
uniprot
Q5U1Y1
canonical
ensembl
ENSRNOG00000023375
resolver
ensembl
ENSRNOG00055029355
resolver
ensembl
ENSRNOG00060029328
resolver
ensembl
ENSRNOG00065022800
resolver
ensp
ENSRNOP00000036566
resolver
ensp
ENSRNOP00000078018
resolver
ensp
ENSRNOP00055041972
resolver
ensp
ENSRNOP00060042466
resolver
ensp
ENSRNOP00065031647
resolver
enst
ENSRNOT00000037016
resolver
enst
ENSRNOT00000113207
resolver
enst
ENSRNOT00055050948
resolver
enst
ENSRNOT00060051047
resolver
enst
ENSRNOT00065038990
resolver
genesymbol
Rab34
resolver
uniprot
A0A8I5YCL7
resolver
uniprot_entry
A0A8I5YCL7_RAT
resolver
uniprot_entry
RAB34_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP. Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs). {ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MNILAPVRRDRVLAELPQCLKKEAALHVRKDFHPRVTCACQEHRTGTVGFKISKVIVVGDLSVGKTCLINRFCKDTFDKNYKATIGVDFEMERFEVLGVPFSLQLWDTAGQERFKCIASTYYRGAQAIIIVFNLNDVASLEHSKQWLADALKENDPSNVLLFLVGSKKDLSTPAQYSLMEKDALKVAQEIKAEYWSVSSLTGENVREFFFRVAALTFEANVLAELEKSGSRHIGDVVRINSDDKNLYLTASKKKATCCP
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB34 transports protein involved in the redistribution of lysosomes to the peri-Golgi region. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Involved in ciliogenesis (By similarity). In particular, it is required for early steps of the intracellular cilium assembly pathway initiated by trafficking and docking of ciliary vesicles to the centrioles in the cytoplasm, followed by axoneme formation in the cytoplasm. After axoneme elongation, the centrioles migrate close to the cell surface so that ciliary vesicles can fuse with the plasma membrane to expose cilia to the extracellular space (By similarity). It seems dispensable for ciliogenesis via the extracellular pathway where cilium assembly begins after migration and docking of the centriole to the plasma membrane (By similarity). Also acts as a positive regulator of hedgehog signaling and regulates ciliary function (By similarity). {ECO:0000250|UniProtKB:P20340, ECO:0000250|UniProtKB:Q64008, ECO:0000250|UniProtKB:Q9BZG1}.
uniprot
proteins
mass_dalton
29103
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
259
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q64008}. Golgi apparatus {ECO:0000250|UniProtKB:Q64008}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q9BZG1}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9BZG1}; Lipid-anchor {ECO:0000250|UniProtKB:Q9BZG1}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9BZG1}. Cell projection, cilium {ECO:0000250|UniProtKB:Q64008}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q9BZG1}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q64008}. Note=Recruited to phagosomes containing S.aureus or Mycobacterium. {ECO:0000250|UniProtKB:Q9BZG1}.
uniprot
proteins