Id2
entrez
25587
canonical
uniprot
P41137
canonical
ensembl
ENSRNOG00000007237
resolver
ensembl
ENSRNOG00055005697
resolver
ensembl
ENSRNOG00060009478
resolver
ensembl
ENSRNOG00065010345
resolver
ensp
ENSRNOP00000009491
resolver
ensp
ENSRNOP00055007028
resolver
ensp
ENSRNOP00060012517
resolver
ensp
ENSRNOP00065012756
resolver
enst
ENSRNOT00000009491
resolver
enst
ENSRNOT00055009187
resolver
enst
ENSRNOT00060016002
resolver
enst
ENSRNOT00065016714
resolver
genesymbol
Id2
resolver
genesymbol_syn
Id-2
resolver
uniprot_entry
ID2_RAT
resolver
amino_acid_sequence
MKAFSPVRSVRKNSLSDHSLGISRSKTPVDDPMSLLYNMNDCYSKLKELVPSIPQNKKVTKMEILQHVIDYILDLQIALDSHPTIVSLHHQRPGQNQTSRTPLTTLNTDISILSLQASEFPSELMSNDSKVLCG
uniprot
proteins
function
FUNCTION: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. Restricts the CLOCK and BMAL1 localization to the cytoplasm. Plays a role in both the input and output pathways of the circadian clock: in the input component, is involved in modulating the magnitude of photic entrainment and in the output component, contributes to the regulation of a variety of liver clock-controlled genes involved in lipid metabolism (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
14989
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in vitro by CDK1, PKA and PKC. {ECO:0000269|PubMed:7864897}.; PTM: Ubiquitinated in a ASB4-dependent manner, leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q02363}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7864897
uniprot
proteins
pubmed
7908517
uniprot
proteins
sequence_length
134
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P41136}. Nucleus {ECO:0000250|UniProtKB:P41136}.
uniprot
proteins