Rspo4
entrez
228770
canonical
uniprot
Q8BJ73
canonical
ensembl
ENSMUSG00000032852
resolver
ensp
ENSMUSP00000041578
resolver
ensp
ENSMUSP00000343085
resolver
genesymbol
Rspo4
resolver
uniprot
Q0P5Y9
resolver
uniprot_entry
Q0P5Y9_MOUSE
resolver
uniprot_entry
RSPO4_MOUSE
resolver
amino_acid_sequence
MRAPLCLLLLLAHAVDMLALYRRKKQAGTGLGGNCTGCVICSEENGCSTCQQRLFLFIRREGIRQYGKCVHDCPLGFFGIRGQEANRCKKCGATCESCFSQDFCIRCKRRFHLYKGKCLPSCPPGTLTHQSTRECQEECEPSPWGSWSPCIHNGKTCGSGWGLETRVREAGPAKQEETASCRVLSESRKCPIKRLCPGERNPRQKNRKDRRQRKDRKLERRPHQRGSQ
uniprot
proteins
function
FUNCTION: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. {ECO:0000269|PubMed:21693646}.
uniprot
proteins
mass_dalton
25866
uniprot
proteins
protein_family
R-spondin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21693646
uniprot
proteins
sequence_length
228
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
uniprot
proteins