Smad6
entrez
17130
canonical
uniprot
O35182
canonical
ensembl
ENSMUSG00000036867
resolver
ensp
ENSMUSP00000036285
resolver
enst
ENSMUST00000041029
resolver
genesymbol
Smad6
resolver
genesymbol_syn
Madh6
resolver
genesymbol_syn
Madh7
resolver
genesymbol_syn
Msmad6
resolver
uniprot
Q9CW62
resolver
uniprot_entry
SMAD6_MOUSE
resolver
uniprot_sec
Q9CW62
resolver
amino_acid_sequence
MFRSKRSGLVRRLWRSRVVPDREEGSGGGGGVDEDGSLGSRAEPAPRAREGGGCSRSEVRSVAPRRPRDAVGPRGAAIAGRRRRTGGLPRPVSESGAGAGGSPLDVAEPGGPGWLPESDCETVTCCLFSERDAAGAPRDSGDPQARQSPEPEEGGGPRSREARSRLLLLEQELKTVTYSLLKRLKERSLDTLLEAVESRGGVPGGCVLVPRADLRLGGQPAPPQLLLGRLFRWPDLQHAVELKPLCGCHSFTAAADGPTVCCNPYHFSRLCGPESPPPPYSRLSPPDQYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDATKPSHWCSVAYWEHRTRVGRLYAVYDQAVSIFYDLPQGSGFCLGQLNLEQRSESVRRTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGGRALVVRKVPPGYSIKVFDFERSGLLQHADAAHGPYDPHSVRISFAKGWGPCYSRQFITSCPCWLEILLNNHR
uniprot
proteins
function
FUNCTION: Acts as an inhibitory regulator of signaling mediated by the TGF-beta superfamily, with strong selectivity toward BMP-dependent pathways. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear translocation and NF-kappa-B-mediated expression of pro-inflammatory genes (PubMed:16951688). Blocks the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Associates with regulatory elements in target promoter regions. Functions as an adapter protein that recruits ubiquitin ligases, including SMURF1 and, in some contexts, SMURF2, promoting proteasomal degradation of signaling components and transcription factors such as RUNX2, TBX6, BMPR1A and MYD88. {ECO:0000250|UniProtKB:O43541, ECO:0000269|PubMed:16951688}.
uniprot
proteins
mass_dalton
53714
uniprot
proteins
mutagenesis
MUTAGEN 74; /note="R->A: Strongly decreased methylation."; /evidence="ECO:0000269|PubMed:23747011
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated at Lys-174 by the E2/E3 hybrid ubiquitin-protein ligase UBE2O, leading to reduced binding affinity for the activated BMP type I receptor ACVR1/ALK2, thereby enhancing BMP7 and regulating adipocyte differentiation (By similarity). Ubiquitinated by WWP1 (PubMed:15221015). Ubiquitinated by ARK2C, promoting proteasomal degradation, leading to enhance the BMP-Smad signaling (PubMed:23610558). {ECO:0000250|UniProtKB:O43541, ECO:0000269|PubMed:15221015, ECO:0000269|PubMed:23610558}.; PTM: Arginine methylation by PRMT1, which is recruited by BMPR2, initiates BMP-Induced signaling and induces dissociation from the BMPR1B receptor at the cell surface leading to derepress downstream Smad1/Smad5 signaling. {ECO:0000269|PubMed:23747011}.; PTM: Phosphorylated by BMP type 1 receptor kinase and by PRKX. {ECO:0000250|UniProtKB:O43541}.
uniprot
proteins
protein_family
Dwarfin/SMAD family
uniprot
proteins
pubmed
14657019
uniprot
proteins
pubmed
15221015
uniprot
proteins
pubmed
15496141
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16951688
uniprot
proteins
pubmed
21897371
uniprot
proteins
pubmed
23610558
uniprot
proteins
pubmed
23747011
uniprot
proteins
pubmed
9335505
uniprot
proteins
sequence_length
495
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O43541}. Cytoplasm {ECO:0000269|PubMed:21897371}.
uniprot
proteins