Slco1b2
entrez
58978
canonical
uniprot
Q9QZX8
canonical
ensembl
ENSRNOG00000030538
resolver
ensembl
ENSRNOG00055010114
resolver
ensembl
ENSRNOG00060007844
resolver
ensembl
ENSRNOG00065011566
resolver
ensp
ENSRNOP00000013409
resolver
ensp
ENSRNOP00000013514
resolver
genesymbol
Slco1b2
resolver
genesymbol_syn
Oatp1b2
resolver
genesymbol_syn
Slc21a10
resolver
uniprot
Q9JHF6
resolver
uniprot
Q9JIM2
resolver
uniprot_entry
SO1B2_RAT
resolver
uniprot_sec
Q9JHF6
resolver
uniprot_sec
Q9JIM2
resolver
amino_acid_sequence
MDHTQQSRKAAEAQPSRSKQTRFCDGFKLFLAALSFSYICKALGGVVMKSSITQIERRFDIPSSISGLIDGGFEIGNLLVIVFVSYFGSKLHRPKLIGIGCFIMGIGSILTALPHFFMGYYKYAKENDIGSLGNSTLTCFINQMTSPTGPSPEIVEKGCEKGLKSHMWIYVLMGNMLRGIGETPIVPLGISYLDDFAKEGHTSMHLGTLHTIAMIGPILGFIMSSVFAKIYVDVGYVDLNSVRITPNDARWVGAWWLSFIVNGLLCITSSIPFFFLPKIPKRSQEERKNSVSLHAPKTDEEKKHMTNLTKQEEQDPSNMTGFLRSLRSILTNEIYVIFLILTLLQVSGFIGSFTYLFKFIEQQFGRTASQANFLLGIITIPTMATAMFLGGYIVKKFKLTSVGIAKFVFFTSSVAYAFQFLYFPLLCENKPFAGLTLTYDGMNPVDSHIDVPLSYCNSDCSCDKNQWEPICGENGVTYISPCLAGCKSFRGDKKPNNTEFYDCSCISNSGNNSAHLGECPRYKCKTNYYFYIILQVTVSFFTAMGSPSLILILMKSVQPELKSLAMGFHSLIIRALGGILAPIYYGAFIDRTCIKWSVTSCGKRGACRLYNSRLFGFSYLGLNLALKTPPLFLYVVLIYFTKRKYKRNDNKTLENGRQFTDEGNPDSVNKNGYYCVPYDEQSNETPL
uniprot
proteins
function
FUNCTION: Mediates the Na(+)-independent uptake of organic anions such as taurochlate, bromosulfophthalein and steroid conjugates (estrone 3-sulfate, 17-beta-glucuronosyl estradiol, dehydroepiandrosterone sulfate) (PubMed:19129463). Also transports prostaglandin E2 and L-thyroxine (T4) (PubMed:19129463). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment (PubMed:19129463). Hydrogencarbonate/HCO3(-) acts as the probable counteranion that exchanges for organic anions (PubMed:19129463). {ECO:0000269|PubMed:19129463}.
uniprot
proteins
mass_dalton
76767
uniprot
proteins
protein_family
Organo anion transporter (TC 2.A.60) family
uniprot
proteins
pubmed
10500057
uniprot
proteins
pubmed
10838093
uniprot
proteins
pubmed
10903899
uniprot
proteins
pubmed
11713643
uniprot
proteins
pubmed
16396499
uniprot
proteins
pubmed
19129463
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
687
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane; Multi-pass membrane protein. Note=Confined to the basolateral plasma membrane of hepatocytes.
uniprot
proteins
transmembrane_region
TRANSMEM 29..48; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 68..88; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 95..119; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 166..194; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 214..234; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 253..277; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 329..350; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 371..394; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 399..422; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 532..554; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 564..589; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 624..641; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins