Pdcd5
entrez
56330
canonical
uniprot
P56812
canonical
ensembl
ENSMUSG00000030417
resolver
ensp
ENSMUSP00000113761
resolver
enst
ENSMUST00000118501
resolver
genesymbol
Pdcd5
resolver
genesymbol_syn
Tfar19
resolver
uniprot
Q564F6
resolver
uniprot_entry
PDCD5_MOUSE
resolver
uniprot_entry
Q564F6_MOUSE
resolver
amino_acid_sequence
MADEELEALRKQRLAELQAKHGDPGDAAQQEAKQREAEMRNSILAQVLDQSARARLSNLALVKPEKTKAVENYLIQMARYGQLSGKVSEQGLIEILEKVSQQTEKKTTVKFNRRKVMDSDEDDADY
uniprot
proteins
function
FUNCTION: In response to DNA damage, associates with TP53/p53 to prevent MDM2-mediated degradation of TP53 and promote TP53-mediated signaling (PubMed:28051100). Also protects KAT5/TIP60 from degradation, which further promotes TP53/p53-mediated signaling (By similarity). {ECO:0000250|UniProtKB:O14737, ECO:0000269|PubMed:28051100}.
uniprot
proteins
mass_dalton
14275
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-119 by casein kinase II. Dephosphorylated at Ser-119 by PPEF1, which promotes its degradation by the proteasome. {ECO:0000250|UniProtKB:O14737}.
uniprot
proteins
protein_family
PDCD5 family
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28051100
uniprot
proteins
pubmed
9920759
uniprot
proteins
sequence_length
126
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O14737}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:O14737}. Note=Accumulates in the nucleus in response to genotoxic stress. {ECO:0000250|UniProtKB:O14737}.
uniprot
proteins