Nudt3
entrez
294292
canonical
uniprot
Q566C7
canonical
ensembl
ENSRNOG00000061176
resolver
ensembl
ENSRNOG00055008448
resolver
ensembl
ENSRNOG00060006364
resolver
ensembl
ENSRNOG00065028834
resolver
ensp
ENSRNOP00000074608
resolver
ensp
ENSRNOP00000094072
resolver
ensp
ENSRNOP00055011504
resolver
ensp
ENSRNOP00060007771
resolver
ensp
ENSRNOP00065040900
resolver
enst
ENSRNOT00000083169
resolver
enst
ENSRNOT00000115403
resolver
enst
ENSRNOT00055014326
resolver
enst
ENSRNOT00060010465
resolver
enst
ENSRNOT00065049813
resolver
genesymbol
Nudt3
resolver
genesymbol_syn
Dipp
resolver
genesymbol_syn
Dipp1
resolver
uniprot
A0A8I6ALX3
resolver
uniprot_entry
A0A8I6ALX3_RAT
resolver
uniprot_entry
NUDT3_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Diphosphoinositol polyphosphate phosphohydrolase is inhibited by fluoride and InsP6. {ECO:0000269|PubMed:9822604}.
uniprot
proteins
amino_acid_sequence
MMKLKSNQTRTYDGDGYKKRAACLCFRSESEEEVLLVSSSRHPDRWIVPGGGMEPEEEPSVAAVREVCEEAGVKGTLGRLVGIFENQERKHRTYVYVLIVTEVLEDWEDSVNIGRKREWFKIEEAVKVLQYHKPVQASYFEALRQGYSANNGTPVLPTTYSSSMSGIR
uniprot
proteins
ec_number
3.6.1.10
uniprot
proteins
ec_number
3.6.1.52
uniprot
proteins
ec_number
3.6.1.59
uniprot
proteins
ec_number
3.6.1.61
uniprot
proteins
ec_number
3.6.1.62
uniprot
proteins
function
FUNCTION: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction (PubMed:9822604). InsP6 (inositol hexakisphosphate) is not a substrate (By similarity). Acts as a negative regulator of the ERK1/2 pathway (By similarity). Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with diadenosine 5',5'''-P1,P6-hexaphosphate (Ap6A) and diadenosine 5',5'''- P1,P5-pentaphosphate (Ap5A) being the preferred substrates (By similarity). The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A (By similarity). Also able to hydrolyze 5- phosphoribose 1-diphosphate (By similarity). Acts as a decapping enzyme that can hydrolyze both monomethylated and unmethylated capped RNAs (By similarity). Hydrolyzes monomethylated capped RNA after both the alpha- and beta-phosphates generating m7GMP + ppRNA and m7GDP + pRNA (By similarity). Modulates the stability of a subset of mRNAs implicated in cell motility (By similarity). Divalent cations zinc, magnesium and manganese determine its substrate specificity (By similarity). Exhibits endopolyphosphatase activity in the presence of zinc ions (PubMed:34788624). Exhibits diphosphoinositol polyphosphate phosphohydrolase in the presence of magnesium ions and diadenosine hexaphosphate hydrolase activity in the presence of manganese ions (By similarity). Plays an important role in limiting DNA damage and maintaining cell survival upon oxidative stress via its endopolyphosphatase activity (By similarity). {ECO:0000250|UniProtKB:O95989, ECO:0000250|UniProtKB:Q9JI46, ECO:0000269|PubMed:34788624, ECO:0000269|PubMed:9822604}.
uniprot
proteins
mass_dalton
19096
uniprot
proteins
protein_family
DIPP subfamily
uniprot
proteins
protein_family
Nudix hydrolase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
34788624
uniprot
proteins
pubmed
9822604
uniprot
proteins
sequence_length
168
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O95989}. Nucleus {ECO:0000250|UniProtKB:O95989}.
uniprot
proteins