INPP4B
entrez
8821
canonical
uniprot
O15327
canonical
ensembl
ENSG00000109452
resolver
ensp
ENSP00000262992
resolver
ensp
ENSP00000421065
resolver
ensp
ENSP00000422793
resolver
ensp
ENSP00000425487
resolver
ensp
ENSP00000426207
resolver
ensp
ENSP00000427250
resolver
ensp
ENSP00000521038
resolver
ensp
ENSP00000521039
resolver
ensp
ENSP00000530942
resolver
ensp
ENSP00000530943
resolver
enst
ENST00000509777
resolver
enst
ENST00000511838
resolver
enst
ENST00000850954
resolver
enst
ENST00000850955
resolver
genesymbol
INPP4B
resolver
hgnc
HGNC:6075
resolver
uniprot
A0ABJ7H3A1
resolver
uniprot
A0ABJ7HAR5
resolver
uniprot
E7EQN9
resolver
uniprot
E9PCZ3
resolver
uniprot
Q2TAI2
resolver
uniprot
Q5XLE7
resolver
uniprot
Q6IN59
resolver
uniprot
Q6PJB4
resolver
uniprot_entry
A0ABJ7H3A1_HUMAN
resolver
uniprot_entry
A0ABJ7HAR5_HUMAN
resolver
uniprot_entry
E7EQN9_HUMAN
resolver
uniprot_entry
E9PCZ3_HUMAN
resolver
uniprot_entry
INP4B_HUMAN
resolver
uniprot_sec
Q2TAI2
resolver
uniprot_sec
Q5XLE7
resolver
uniprot_sec
Q6IN59
resolver
uniprot_sec
Q6PJB4
resolver
activity_regulation
ACTIVITY REGULATION: Strongly inhibited by inositol hexakisphosphate. {ECO:0000250|UniProtKB:Q9QWG5}.
uniprot
proteins
amino_acid_sequence
MEIKEEGASEEGQHFLPTAQANDPGDCQFTSIQKTPNEPQLEFILACKDLVAPVRDRKLNTLVQISVIHPVEQSLTRYSSTEIVEGTRDPLFLTGVTFPSEYPIYEETKIKLTVYDVKDKSHDTVRTSVLPEHKDPPPEVGRSFLGYASFKVGELLKSKEQLLVLSLRTSDGGKVVGTIEVSVVKMGEIEDGEADHITTDVQGQKCALVCECTAPESVSGKDNLPFLNSVLKNPVCKLYRFPTSDNKWMRIREQMSESILSFHIPKELISLHIKEDLCRNQEIKELGELSPHWDNLRKNVLTHCDQMVNMYQDILTELSKETGSSFKSSSSKGEKTLEFVPINLHLQRMQVHSPHLKDALYDVITVGAPAAHFQGFKNGGLRKLLHRFETERRNTGYQFIYYSPENTAKAKEVLSNINQLQPLIATHADLLLNSASQHSPDSLKNSLKMLSEKTELFVHAFKDQLVRSALLALYTARPGGILKKPPSPKSSTEESSPQDQPPVMRGQDSIPHHSDYDEEEWDRVWANVGKSLNCIIAMVDKLIERDGGSEGSGGNNDGEKEPSLTDAIPSHPREDWYEQLYPLILTLKDCMGEVVNRAKQSLTFVLLQELAYSLPQCLMLTLRRDIVFSQALAGLVCGFIIKLQTSLYDPGFLQQLHTVGLIVQYEGLLSTYSDEIGMLEDMAVGISDLKKVAFKIIEAKSNDVLPVITGRREHYVVEVKLPARMFESLPLQIKEGQLLHVYPVLFNVGINEQQTLAERFGDVSLQESINQENFELLQEYYKIFMEKMPPDYISHFQEQNDLKALLENLLQNIQSKKRKNVEIMWLAATICRKLNGIRFTCCKSAKDRTSMSVTLEQCSILRDEHQLHKDFFIRALDCMRREGCRIENVLKNIKCRKYAFNMLQLMAFPKYYRPPEGTYGKADT
uniprot
proteins
ec_number
3.1.3.66
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate (PubMed:24070612, PubMed:24591580). Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles (PubMed:24591580). The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:19647222, PubMed:24070612). {ECO:0000269|PubMed:19647222, ECO:0000269|PubMed:24070612, ECO:0000269|PubMed:24591580}.
uniprot
proteins
mass_dalton
104738
uniprot
proteins
mutagenesis
MUTAGEN 842; /note="C->S: Abolished phosphotyrosine phosphatase activity."; /evidence="ECO:0000269|PubMed:24070612"; MUTAGEN 843; /note="K->M: Increased phosphotyrosine phosphatase activity. Does not alter lipid phosphatase activity for the substrate phosphatidylinositol(3,4)P2, but reduced hydrolysis of inositol(1,3,4)P3 by about 70%."; /evidence="ECO:0000269|PubMed:24070612"; MUTAGEN 846; /note="K->M: Does not alter phosphotyrosine phosphatase activity. Abolished lipid phosphatase activity."; /evidence="ECO:0000269|PubMed:24070612"; MUTAGEN 847; /note="D->E: Significantly reduces phosphotyrosine phosphatase activity. Not able to dephosphorylate phosphatidylinositol(3,4)P2 but retains approximately 35% of activity towards Inosotol(1,3,4)P3."; /evidence="ECO:0000269|PubMed:24070612
uniprot
proteins
pathway_participation
PATHWAY: Signal transduction; phosphatidylinositol signaling pathway. {ECO:0000250|UniProtKB:Q9QWG5}.
uniprot
proteins
protein_family
4-bisphosphate 4-phosphatase family
uniprot
proteins
protein_family
Inositol 3
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
19647222
uniprot
proteins
pubmed
24070612
uniprot
proteins
pubmed
24591580
uniprot
proteins
pubmed
9295334
uniprot
proteins
sequence_length
924
uniprot
proteins