Cnga2
entrez
25411
canonical
uniprot
Q00195
canonical
ensembl
ENSRNOG00000030119
resolver
ensp
ENSRNOP00000016415
resolver
enst
ENSRNOT00000016415
resolver
genesymbol
Cnga2
resolver
genesymbol_syn
Cncg2
resolver
uniprot
F1LS43
resolver
uniprot
Q549G7
resolver
uniprot_entry
CNGA2_RAT
resolver
uniprot_entry
F1LS43_RAT
resolver
uniprot_sec
Q549G7
resolver
activity_regulation
ACTIVITY REGULATION: The channel activity is inhibited by L-cis diltiazem. {ECO:0000269|PubMed:1697649}.
uniprot
proteins
amino_acid_sequence
MMTEKSNGVKSSPANNHNHHPPPSIKANGKDDHRAGSRPQSVAADDDTSPELQRLAEMDTPRRGRGGFQRIVRLVGVIRDWANKNFREEEPRPDSFLERFRGPELQTVTTHQGDDKGGKDGEGKGTKKKFELFVLDPAGDWYYRWLFVIAMPVLYNWCLLVARACFSDLQRNYFVVWLVLDYFSDTVYIADLIIRLRTGFLEQGLLVKDPKKLRDNYIHTLQFKLDVASIIPTDLIYFAVGIHSPEVRFNRLLHFARMFEFFDRTETRTSYPNIFRISNLVLYILVIIHWNACIYYVISKSIGFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKDMEAKVIKWFDYLWTNKKTVDEREVLKNLPAKLRAEIAINVHLSTLKKVRIFQDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDENEVAASMEVDVQEKLEQLETNMDTLYTRFARLLAEYTGAQQKLKQRITVLETKMKQNHEDDYLSDGINTPEPTAAE
uniprot
proteins
function
FUNCTION: Pore-forming subunit of the olfactory cyclic nucleotide-gated channel. Operates in the cilia of olfactory sensory neurons where chemical stimulation of the odorant is converted to an electrical signal. Mediates odorant-induced cAMP-dependent Ca(2+) influx triggering neuron depolarization. The rise of intracellular Ca(2+) levels potentiates the olfactory response by activating Ca(2+)-dependent Cl(-) channels, but it also serves as a negative feedback signal to desensitize the channel for rapid adaptation to odorants. Conducts cAMP- and cGMP-gated ion currents, with permeability for monovalent and divalent cations. Also expressed in a subpopulation of sensory neurons of the main olfactory epithelium (type B cells), where it mediates Ca(2+) influx in response to hydrogen sulfide, and is required for defensive behavioral responses to this stimulus (By similarity). {ECO:0000250|UniProtKB:Q62398, ECO:0000269|PubMed:10377344, ECO:0000269|PubMed:1697649, ECO:0000269|PubMed:27405959, ECO:0000269|PubMed:7522325, ECO:0000269|PubMed:9878057}.
uniprot
proteins
mass_dalton
76177
uniprot
proteins
mutagenesis
MUTAGEN 538; /note="R->E: Markedly decreases the affinity of the channel for cGMP."; /evidence="ECO:0000269|PubMed:27405959"; MUTAGEN 539; /note="T->M: Slightly decreases the affinity of the channel for cGMP."; /evidence="ECO:0000269|PubMed:27405959
uniprot
proteins
protein_family
CNGA2 subfamily
uniprot
proteins
protein_family
Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family
uniprot
proteins
pubmed
10377344
uniprot
proteins
pubmed
10594674
uniprot
proteins
pubmed
11764791
uniprot
proteins
pubmed
1697649
uniprot
proteins
pubmed
27405959
uniprot
proteins
pubmed
7522325
uniprot
proteins
pubmed
9878057
uniprot
proteins
sequence_length
664
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000269|PubMed:10377344}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 147..168; /note="Helical; Name=S1"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 179..199; /note="Helical; Name=S2"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 225..243; /note="Helical; Name=S3"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 249..267; /note="Helical; Name=S4"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 275..298; /note="Helical; Name=S5"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 322..356; /note="Helical; Name=P-helix"; /evidence="ECO:0000250|UniProtKB:P29973"; TRANSMEM 357..381; /note="Helical; Name=S6"; /evidence="ECO:0000250|UniProtKB:P29973
uniprot
proteins