Sct
entrez
20287
canonical
uniprot
Q08535
canonical
ensembl
ENSMUSG00000038580
resolver
ensp
ENSMUSP00000041519
resolver
ensp
ENSMUSP00000128729
resolver
ensp
ENSMUSP00000147780
resolver
ensp
ENSMUSP00000354696
resolver
enst
ENSMUST00000046156
resolver
enst
ENSMUST00000167790
resolver
enst
ENSMUST00000211667
resolver
genesymbol
Sct
resolver
uniprot
A0A1B0GS37
resolver
uniprot
F8WIW5
resolver
uniprot
Q3UKU8
resolver
uniprot
Q80ZS9
resolver
uniprot_entry
A0A1B0GS37_MOUSE
resolver
uniprot_entry
F8WIW5_MOUSE
resolver
uniprot_entry
Q3UKU8_MOUSE
resolver
uniprot_entry
Q80ZS9_MOUSE
resolver
uniprot_entry
SECR_MOUSE
resolver
amino_acid_sequence
MEPPLPTPMLLLLLLLLSSSAALPAPPRTPRHSDGMFTSELSRLQDSARLQRLLQGLVGKRSEQDTENIPENSLARSKPLEDQLCLLWSNTQTLQDWLLPRLSLDGSLSLWLPPGPRSAVDRSEWTETTRPPR
uniprot
proteins
function
FUNCTION: Hormone involved in different processes, such as regulation of the pH of the duodenal content, food intake and water homeostasis (PubMed:20578263, PubMed:20739612, PubMed:20927047, PubMed:30449620). Exerts its biological effects by binding to secretin receptor (SCTR), a G protein-coupled receptor expressed in the basolateral domain of several cells (PubMed:30449620). Acts as a key gastrointestinal hormone by regulating the pH of the duodenal content (PubMed:20578263). Secreted by S cells of the duodenum in the crypts of Lieberkuehn and regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas (PubMed:20578263). Production of bicarbonate is essential to neutralize the pH and ensure no damage is done to the small intestine by the gastric acid (PubMed:20578263). In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation (PubMed:30449620). Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation (PubMed:30449620). Also able to stimulate lipolysis in white adipocytes (PubMed:24273196). Also plays an important role in cellular osmoregulation: released into the systemic circulation in response to hyperosmolality and acts at different levels in the hypothalamus, pituitary and kidney to regulate water homeostasis (PubMed:20739612). Also plays a role in the central nervous system, possibly by acting as a neuropeptide hormone: required for hippocampal synaptic function and neural progenitor cells maintenance (PubMed:18534766, PubMed:21159798). {ECO:0000269|PubMed:18534766, ECO:0000269|PubMed:20578263, ECO:0000269|PubMed:20739612, ECO:0000269|PubMed:20927047, ECO:0000269|PubMed:21159798, ECO:0000269|PubMed:24273196, ECO:0000269|PubMed:30449620}.
uniprot
proteins
mass_dalton
14914
uniprot
proteins
protein_family
Glucagon family
uniprot
proteins
pubmed
18534766
uniprot
proteins
pubmed
20578263
uniprot
proteins
pubmed
20739612
uniprot
proteins
pubmed
20927047
uniprot
proteins
pubmed
21159798
uniprot
proteins
pubmed
24273196
uniprot
proteins
pubmed
30449620
uniprot
proteins
pubmed
8179583
uniprot
proteins
sequence_length
133
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P11384}.
uniprot
proteins