ALKBH6
entrez
84964
canonical
uniprot
Q3KRA9
canonical
ensembl
ENSG00000239382
resolver
ensp
ENSP00000252984
resolver
ensp
ENSP00000368152
resolver
ensp
ENSP00000435496
resolver
ensp
ENSP00000567871
resolver
ensp
ENSP00000667957
resolver
genesymbol
ALKBH6
resolver
genesymbol_syn
ABH6
resolver
hgnc
HGNC:28243
resolver
uniprot
A5LGM8
resolver
uniprot
A6NLP1
resolver
uniprot
A8MU96
resolver
uniprot
B2RAE0
resolver
uniprot
B4E3P3
resolver
uniprot_entry
ALKB6_HUMAN
resolver
uniprot_entry
B2RAE0_HUMAN
resolver
uniprot_entry
B4E3P3_HUMAN
resolver
uniprot_sec
A5LGM8
resolver
uniprot_sec
A6NLP1
resolver
uniprot_sec
A8MU96
resolver
amino_acid_sequence
MEEQDARVPALEPFRVEQAPPVIYYVPDFISKEEEEYLLRQVFNAPKPKWTQLSGRKLQNWGGLPHPRGMVPERLPPWLQRYVDKVSNLSLFGGLPANHVLVNQYLPGEGIMPHEDGPLYYPTVSTISLGSHTVLDFYEPRRPEDDDPTEQPRPPPRPTTSLLLEPRSLLVLRGPAYTRLLHGIAAARVDALDAASSPPNAAACPSARPGACLVRGTRVSLTIRRVPRVLRAGLLLGK
uniprot
proteins
ec_number
1.14.11.-
uniprot
proteins
function
FUNCTION: Probable Fe(2+)/2-oxoglutarate-dependent dioxygenase involved in oxidative demethylation of nucleic acids (PubMed:39845104). Binds nucleic acids with a preference for ssDNA or ssRNA to other types of DNAs (PubMed:35120926). May play a role in nucleic acid damage repair (PubMed:35120926). {ECO:0000269|PubMed:35120926, ECO:0000269|PubMed:39845104}.
uniprot
proteins
mass_dalton
26483
uniprot
proteins
mutagenesis
MUTAGEN 68; /note="R->A: Almost completely abolished the ssDNA binding activity."; /evidence="ECO:0000269|PubMed:35120926"; MUTAGEN 74; /note="R->A: Almost completely abolished the ssDNA binding activity."; /evidence="ECO:0000269|PubMed:35120926"; MUTAGEN 103; /note="N->A: Reduces the binding of 2-oxoglutarate; when associated with A-105 and A-218."; /evidence="ECO:0000269|PubMed:35120926"; MUTAGEN 105; /note="Y->A: Reduces the binding of 2-oxoglutarate; when associated with A-103 and A-218."; /evidence="ECO:0000269|PubMed:35120926"; MUTAGEN 218; /note="R->A: Reduces the binding of 2-oxoglutarate; when associated with A-103 and A-105."; /evidence="ECO:0000269|PubMed:35120926
uniprot
proteins
protein_family
AlkB family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17979886
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
22948820
uniprot
proteins
pubmed
35120926
uniprot
proteins
pubmed
39845104
uniprot
proteins
sequence_length
238
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17979886}. Nucleus {ECO:0000269|PubMed:17979886}.
uniprot
proteins