STAMBPL1
entrez
57559
canonical
uniprot
Q96FJ0
canonical
ensembl
ENSG00000138134
resolver
ensp
ENSP00000360994
resolver
ensp
ENSP00000533372
resolver
ensp
ENSP00000533373
resolver
ensp
ENSP00000533374
resolver
ensp
ENSP00000533376
resolver
ensp
ENSP00000597894
resolver
ensp
ENSP00000621726
resolver
ensp
ENSP00000621728
resolver
genesymbol
STAMBPL1
resolver
genesymbol_syn
AMSHLP
resolver
genesymbol_syn
KIAA1373
resolver
hgnc
HGNC:24105
resolver
uniprot
B3KPA7
resolver
uniprot
Q5T9N4
resolver
uniprot
Q5T9N9
resolver
uniprot
Q7Z420
resolver
uniprot
Q9P2H4
resolver
uniprot_entry
STALP_HUMAN
resolver
uniprot_sec
B3KPA7
resolver
uniprot_sec
Q5T9N4
resolver
uniprot_sec
Q5T9N9
resolver
uniprot_sec
Q7Z420
resolver
uniprot_sec
Q9P2H4
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by UbV(SP.1), an ubiquitin variant that also inhibits STAMBP. {ECO:0000269|PubMed:34425109}.
uniprot
proteins
amino_acid_sequence
MDQPFTVNSLKKLAAMPDHTDVSLSPEERVRALSKLGCNITISEDITPRRYFRSGVEMERMASVYLEEGNLENAFVLYNKFITLFVEKLPNHRDYQQCAVPEKQDIMKKLKEIAFPRTDELKNDLLKKYNVEYQEYLQSKNKYKAEILKKLEHQRLIEAERKRIAQMRQQQLESEQFLFFEDQLKKQELARGQMRSQQTSGLSEQIDGSALSCFSTHQNNSLLNVFADQPNKSDATNYASHSPPVNRALTPAATLSAVQNLVVEGLRCVVLPEDLCHKFLQLAESNTVRGIETCGILCGKLTHNEFTITHVIVPKQSAGPDYCDMENVEELFNVQDQHDLLTLGWIHTHPTQTAFLSSVDLHTHCSYQLMLPEAIAIVCSPKHKDTGIFRLTNAGMLEVSACKKKGFHPHTKEPRLFSICKHVLVKDIKIIVLDLR
uniprot
proteins
ec_number
3.4.19.-
uniprot
proteins
function
FUNCTION: Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:18758443, PubMed:35114100). Acts as a positive regulator of the TORC1 signaling pathway by mediating 'Lys-63'-linked deubiquitination of SESN2, thereby inhibiting SESN2-interaction with the GATOR2 complex (PubMed:35114100). Does not cleave 'Lys-48'-linked polyubiquitin chains (PubMed:18758443). {ECO:0000269|PubMed:18758443, ECO:0000269|PubMed:35114100}.
uniprot
proteins
mass_dalton
49783
uniprot
proteins
mutagenesis
MUTAGEN 292; /note="E->A: Complete loss of catalytic activity."; /evidence="ECO:0000269|PubMed:18758443, ECO:0000269|PubMed:35114100"; MUTAGEN 329; /note="E->A: 3-fold decrease in substrate affinity."; /evidence="ECO:0000269|PubMed:18758443"; MUTAGEN 332; /note="F->A: 12-fold decrease in substrate affinity, little effect on catalytic activity."; /evidence="ECO:0000269|PubMed:18758443"; MUTAGEN 353; /note="T->A: 19-fold decrease in activity, no change in substrate affinity."; /evidence="ECO:0000269|PubMed:18758443"; MUTAGEN 355; /note="F->A: 161-fold decrease in activity, no change in substrate affinity."; /evidence="ECO:0000269|PubMed:18758443"; MUTAGEN 357; /note="S->A: 34-fold decrease in activity."; /evidence="ECO:0000269|PubMed:18758443"; MUTAGEN 358; /note="S->A: 10-fold decrease in activity, no change in substrate affinity."; /evidence="ECO:0000269|PubMed:18758443"; MUTAGEN 360; /note="D->A: Complete loss of catalytic activity."; /evidence="ECO:0000269|PubMed:18758443, ECO:0000269|PubMed:35114100"; MUTAGEN 370; /note="M->A: 18-fold decrease in substrate affinity, little effect on catalytic activity."; /evidence="ECO:0000269|PubMed:18758443"; MUTAGEN 402; /note="C->S: 402-fold decrease in activity, slight increase in substrate affinity."; /evidence="ECO:0000269|PubMed:18758443"; MUTAGEN 407; /note="F->A: 35-fold decrease in activity, slight increase in substrate affinity."; /evidence="ECO:0000269|PubMed:18758443
uniprot
proteins
protein_family
Peptidase M67C family
uniprot
proteins
pubmed
10718198
uniprot
proteins
pubmed
12810066
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18758443
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
34425109
uniprot
proteins
pubmed
35114100
uniprot
proteins
sequence_length
436
uniprot
proteins