Fhit
entrez
60398
canonical
uniprot
Q9JIX3
canonical
ensembl
ENSRNOG00000064939
resolver
ensp
ENSRNOP00000080145
resolver
enst
ENSRNOT00000109492
resolver
genesymbol
Fhit
resolver
uniprot
A0A8I5ZQ19
resolver
uniprot_entry
A0A8I5ZQ19_RAT
resolver
uniprot_entry
FHIT_RAT
resolver
amino_acid_sequence
MSFKFGQHLIKPSVVFLKTELSFALVNRKPVVPGHVLMCPLRPVERFRDLRPDEVADLFQVTQRVGTVVEKHFQGTSITFSMQDGPEAGQTVKHVHVHILPRKSGDFRRNDNIYDELQKHDREEEDSPAFWRSEEEMAAEAEVLRAYFQA
uniprot
proteins
ec_number
2.7.7.51
uniprot
proteins
ec_number
3.6.1.29
uniprot
proteins
ec_number
3.6.2.1
uniprot
proteins
ec_number
3.9.1.-
uniprot
proteins
function
FUNCTION: Possesses dinucleoside triphosphate hydrolase activity (By similarity). Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP (By similarity). Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A), but has extremely low activity with ATP (By similarity). Exhibits adenylylsulfatase activity, hydrolyzing adenosine 5'-phosphosulfate to yield AMP and sulfate (By similarity). Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (By similarity). Exhibits adenylylsulfate-ammonia adenylyltransferase, catalyzing the ammonolysis of adenosine 5'-phosphosulfate resulting in the formation of adenosine 5'-phosphoramidate (By similarity). Also catalyzes the ammonolysis of adenosine 5-phosphorofluoridate and diadenosine triphosphate (By similarity). Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5 (By similarity). Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways (By similarity). Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis (By similarity). Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity (By similarity) Functions as a tumor suppressor (By similarity). {ECO:0000250|UniProtKB:O89106, ECO:0000250|UniProtKB:P49789}.
uniprot
proteins
mass_dalton
17348
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Tyr-114 by SRC is required for induction of apoptosis. {ECO:0000250|UniProtKB:P49789}.
uniprot
proteins
sequence_length
150
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P49789}. Nucleus {ECO:0000250|UniProtKB:P49789}. Mitochondrion {ECO:0000250|UniProtKB:P49789}.
uniprot
proteins