Fcmr
entrez
69169
canonical
uniprot
A1KXC4
canonical
ensembl
ENSMUSG00000042474
resolver
ensp
ENSMUSP00000048303
resolver
enst
ENSMUST00000038829
resolver
genesymbol
Fcmr
resolver
genesymbol_syn
Faim3
resolver
genesymbol_syn
Toso
resolver
uniprot
A0A0G2LB91
resolver
uniprot
A1KXC6
resolver
uniprot
A1KXC8
resolver
uniprot
A1KXC9
resolver
uniprot
Q148B9
resolver
uniprot
Q9D8T1
resolver
uniprot_entry
A0A0G2LB91_MOUSE
resolver
uniprot_entry
FCMR_MOUSE
resolver
uniprot_sec
A1KXC6
resolver
uniprot_sec
A1KXC8
resolver
uniprot_sec
A1KXC9
resolver
uniprot_sec
Q148B9
resolver
uniprot_sec
Q9D8T1
resolver
amino_acid_sequence
MDFWLWLLYFLPVSGALRVLPEVQLNVEWGGSIIIECPLPQLHVRMYLCRQMAKPGICSTVVSNTFVKKEYERRVTLTPCLDKKLFLVEMTQLTENDDGIYACGVGMKTDKGKTQKITLNVHNEYPEPFWEDEWTSERPRWLHRFLQHQMPWLHGSEHPSSSGVIAKVTTPAPKTEAPPVHQPSSITSVTQHPRVYRAFSVSATKSPALLPATTASKTSTQQAIRPLEASYSHHTRLHEQRTRHHGPHYGREDRGLHIPIPEFHILIPTFLGFLLLVLLGLVVKRAIQRRRASSRRAGRLAMRRRGRGASRPFPTQRRDASQRPRSQNNVYSACPRRARGPDSLGPAEAPLLNAPASASPASPQVLEAPWPHTPSLKMSCEYVSLGYQPAVNLEDPDSDDYINIPDPSHLPSYAPGPRSSCP
uniprot
proteins
function
FUNCTION: High-affinity Fc receptor for immunoglobulin M (IgM), both secreted and membrane-bound IgM (By similarity). Primarily regulates IgM transport and homeostasis. In lymphoid cells, enables exocytosis of membrane-bound IgM on the plasma membrane as well as endocytosis of IgM-antigen complexes toward lysosomes for degradation. In mucosal epithelium, mediates retrotranscytosis of antigen-IgM complexes across mucosal M cells toward antigen-presenting cells in mucosal lymphoid tissues (PubMed:28135254, PubMed:34788614). Triggers costimulatory signaling and mediates most of IgM effector functions involved in B cell development and primary immune response to infection. Likely limits tonic IgM BCR signaling to self-antigens for proper negative selection of autoreactive B cells in the bone marrow and for the maintenance of regulatory B cell pool in peripheral lymphoid organs. Mediates antibody responses to T cell-dependent and T cell-independent antigens and promotes induction of an efficient neutralizing IgG response. Engages in cross-talk with antigen-receptor signaling via the non-canonical NF-kappa-B, MAP kinases and calcium signaling pathways (By similarity) (PubMed:22988094, PubMed:23267023, PubMed:25732732, PubMed:28135254, PubMed:29461978). {ECO:0000250|UniProtKB:O60667, ECO:0000269|PubMed:22988094, ECO:0000269|PubMed:23267023, ECO:0000269|PubMed:25732732, ECO:0000269|PubMed:28135254, ECO:0000269|PubMed:29461978, ECO:0000269|PubMed:34788614}.
uniprot
proteins
mass_dalton
47471
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on both Tyr and Ser residues. {ECO:0000250|UniProtKB:O60667}.; PTM: O-glycosylated. Sialylated. O-linked glycans regulate trafficking to the plasma membrane. {ECO:0000250|UniProtKB:O60667}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
22988094
uniprot
proteins
pubmed
23267023
uniprot
proteins
pubmed
25732732
uniprot
proteins
pubmed
28135254
uniprot
proteins
pubmed
29461978
uniprot
proteins
pubmed
34788614
uniprot
proteins
sequence_length
422
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22988094, ECO:0000269|PubMed:25732732, ECO:0000269|PubMed:28135254}; Single-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:O60667}; Single-pass membrane protein {ECO:0000255}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:28135254}; Single-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:O60667}; Single-pass membrane protein {ECO:0000255}. Note=Continuously recycles between cytoplasmic pool and the plasma membrane to bind as much IgM as possible (By similarity). In immature B cells, colocalizes with IgM in the trans-Golgi network and plasma membrane (PubMed:28135254). {ECO:0000250|UniProtKB:O60667, ECO:0000269|PubMed:28135254}.
uniprot
proteins
transmembrane_region
TRANSMEM 263..283; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins