Tmem231
entrez
234740
canonical
uniprot
Q3U284
canonical
ensembl
ENSMUSG00000031951
resolver
ensp
ENSMUSP00000034429
resolver
enst
ENSMUST00000034429
resolver
genesymbol
Tmem231
resolver
uniprot
Q497S7
resolver
uniprot_entry
TM231_MOUSE
resolver
uniprot_sec
Q497S7
resolver
amino_acid_sequence
MALYHLFSHPIERAYRAGLCSKAALFLLLTTALTYIPPLLVAFRSHGFWLKRSSYEEQPNVRFQHQVLLVALLGPEPEAFLAWSTFPTFNRLQGAHLRVPLVSSREEDRNQDGKMDVLYFKLELPLQPTEHVLGVQLILTFSYQLHRMSTFEMQSMAFLQSSFAVPGSQLYVNGDLRLQQKQPLSYRGLDIRYNVSVINGTSPFAQDYDLTHIVAAYQERNVTTVLSDPNPIWLVGRAAEAPFVIHAVIRYPTEVISYQPGFWEMIKFAWIQYVSILLIFLWVFERIKIFVFQNQVVTSIPVAVPQGEIRKEHLS
uniprot
proteins
function
FUNCTION: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling. {ECO:0000269|PubMed:22179047}.
uniprot
proteins
mass_dalton
36261
uniprot
proteins
protein_family
TMEM231 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
22179047
uniprot
proteins
sequence_length
315
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium membrane {ECO:0000269|PubMed:22179047}; Multi-pass membrane protein {ECO:0000269|PubMed:22179047}. Note=Localizes to the transition zone of primary cilia; SEPT2 is required for localization to the transition zone.
uniprot
proteins
transmembrane_region
TRANSMEM 23..43; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 262..282; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins