Coxfa4l3
entrez
302884
canonical
uniprot
Q5RK28
canonical
ensembl
ENSRNOG00000067060
resolver
ensembl
ENSRNOG00055003593
resolver
ensembl
ENSRNOG00060018140
resolver
ensembl
ENSRNOG00065028008
resolver
ensp
ENSRNOP00000106877
resolver
ensp
ENSRNOP00055004181
resolver
ensp
ENSRNOP00060025205
resolver
ensp
ENSRNOP00065039606
resolver
enst
ENSRNOT00000073569
resolver
enst
ENSRNOT00055005601
resolver
enst
ENSRNOT00060031105
resolver
enst
ENSRNOT00065048269
resolver
genesymbol
Coxfa4l3
resolver
genesymbol_syn
Nmes1
resolver
uniprot_entry
CX4L3_RAT
resolver
amino_acid_sequence
MGIFQRLMKNKELIPLAFFISAAATGASSFALYALKKTDVVIDRKRNPEPWETVDPTQPQKLLTINQEWKPVEELQRVRRATR
uniprot
proteins
function
FUNCTION: Mitochondrial small peptide that orchestrates a two-pronged immunoregulatory mechanism in response to inflammatory stimuli. Replaces the canonical cytochrome c oxidase subunit COXFA4 in mitochondrial complex IV and targets it to degradation, attenuating mitochondrial respiration, reducing membrane potential as well as ROS generation and modulates innate immune signaling. Additionally, initiates stress-independent autophagy by lowering ATP levels, activating AMPK-ULK1 signaling, boosting glutathione production, and thereby mitigating oxidative stress and supporting immune tolerance. {ECO:0000250|UniProtKB:Q810Q5}.
uniprot
proteins
mass_dalton
9598
uniprot
proteins
protein_family
Complex IV COXFA4 subunit family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
83
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q810Q5}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..35; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins