Bach2
entrez
12014
canonical
uniprot
P97303
canonical
ensembl
ENSMUSG00000040270
resolver
ensp
ENSMUSP00000103815
resolver
ensp
ENSMUSP00000131592
resolver
genesymbol
Bach2
resolver
uniprot
A2ANU8
resolver
uniprot
A2ANU9
resolver
uniprot
A2RRI0
resolver
uniprot_entry
BACH2_MOUSE
resolver
uniprot_sec
A2ANU8
resolver
uniprot_sec
A2ANU9
resolver
uniprot_sec
A2RRI0
resolver
amino_acid_sequence
MSVDEKPGSPMYVYESTVHCANILLGLNDQRKKDILCDVTLIVERKEFRAHRAVLAACSEYFWQALVGQTKDDLVVSLPEEVTARGFGPLLQFAYTAKLLLSRENIREVIRCAEFLRMHNLEDSCFSFLQTQLLNREDGLFVCRKDSACQRPQEDHGNSAGEEEEEEETMDSETARMACATDQMLPDPISFEATAIPVAEKEEALLPESEVPTDTKENSEKGALTQYPRYKKYQLACTKNVYSAPSHGTSGFASTFSEDSPGNSLKPGLPMGQIKSEPPSEETEEESITLCLSGDETDIKDRPGDVEMDRKQPSPAPTPSTPTGAACLDRSRSVSSPSCLRSLFGITKGVESTGLPSTSQQPLVRSSACPFNKGISQGDLKTDYTPLAGNYGQPHVGQKDVSNFAMGSPLRGPGPETLCKQEGELDRRSVIFSASACDQPNTPVHSYSAVSNLDKDLSEPVPKSLWVGAGQSLPSSQAYSHSGLMADHLPGRIRPNTSCPVPIKVCPRSPPLETRTRTSSSCSSYSYAEDGSGGSPCSLPLCEFSSSPCSQGARFLATEHQEPGLMGDGMYNQVRPQIKCEQSYGTNSSDESGSFSEADSESCPVQDRGQEVKLPFPVDQITDLPRNDFQMMIKMHKLTSEQLEFIHDIRRRSKNRIAAQRCRKRKLDCIQNLECEIRKLVCEKEKLLSERNHLKACMGELLDNFSCLSQEVCRDIQSPEQIQALHRYCPVLIPMDLPGASVNPPPVGVEQSLAPSPCAVGGSVPCCLEPGAAPPGLPWVPSNTSENCTSGRRLEGSDPGTFSERGPPLEARSQSVTVDFCQEMTEKCTTDEQPRKDYA
uniprot
proteins
function
FUNCTION: Transcriptional regulator that acts as a repressor or activator (PubMed:8887638). Binds to Maf recognition elements (MARE) (PubMed:8887638). Plays an important role in coordinating transcription activation and repression by MAFK (PubMed:8887638). Induces apoptosis in response to oxidative stress through repression of the antiapoptotic factor HMOX1 (By similarity). Positively regulates the nuclear import of actin (PubMed:26021350). Is a key regulator of adaptive immunity, crucial for the maintenance of regulatory T-cell function and B-cell maturation (PubMed:28530713). {ECO:0000250|UniProtKB:Q9BYV9, ECO:0000269|PubMed:26021350, ECO:0000269|PubMed:28530713}.
uniprot
proteins
mass_dalton
91836
uniprot
proteins
post_translational_modification
PTM: The reversible disulfide bond may provide a mechanism to regulate the activity in oxidative stress responses. {ECO:0000250|UniProtKB:Q9BYV9}.; PTM: Phosphorylation at Ser-520 downstream of the PI-3K pathway promotes nuclear export. {ECO:0000250|UniProtKB:Q9BYV9}.
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
protein_family
CNC subfamily
uniprot
proteins
pubmed
10809773
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26021350
uniprot
proteins
pubmed
28530713
uniprot
proteins
pubmed
8887638
uniprot
proteins
sequence_length
839
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10809773}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:10809773}. Note=Nucleocytoplasmic shuttling is controlled by phosphorylation. {ECO:0000250|UniProtKB:Q9BYV9}.
uniprot
proteins