Ppp1r8
entrez
100336
canonical
uniprot
Q8R3G1
canonical
ensembl
ENSMUSG00000028882
resolver
ensp
ENSMUSP00000030702
resolver
ensp
ENSMUSP00000101539
resolver
enst
ENSMUST00000030702
resolver
enst
ENSMUST00000105919
resolver
genesymbol
Ppp1r8
resolver
genesymbol_syn
Nipp1
resolver
uniprot
A2ADR8
resolver
uniprot
Q8C087
resolver
uniprot_entry
A2ADR8_MOUSE
resolver
uniprot_entry
PP1R8_MOUSE
resolver
uniprot_sec
Q8C087
resolver
amino_acid_sequence
MAAAVNSGSSLPLFDCPTWAGKPPPGLHLDVVKGDKLIEKLIIDEKKYYLFGRNPDLCDFTIDHQSCSRVHAALVYHKHLKRVFLIDLNSTHGTFLGHIRLEPHKPQQIPIDSTVSFGASTRAYTLREKPQTLPSAVKGDEKMGGEDDELKGLLGLPEEETELDNLTEFNTAHNKRISTLTIEEGNLDIQRPKRKRKNSRVTFSEDDEIINPEDVDPSVGRFRNMVQTAVVPVKKKRMEGSGSLGLEESGSRRMQNFAFSGGLYGGLPPTHSETGSQPHGIHGTALIGGLPMPYPNLAPDVDLTPVVPSAVAINPTPNPAVYNPEAVNEPKKKKYAKEAWPGKKPTPSLLI
uniprot
proteins
function
FUNCTION: Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Essential for cell proliferation and early embryonic development. {ECO:0000269|PubMed:15199142, ECO:0000269|PubMed:15501817}.
uniprot
proteins
mass_dalton
38528
uniprot
proteins
post_translational_modification
PTM: May be inactivated by phosphorylation on Ser-199 or Ser-204. {ECO:0000250}.
uniprot
proteins
pubmed
12788942
uniprot
proteins
pubmed
15199142
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15501817
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18253837
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
351
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus speckle {ECO:0000250}. Note=Mainly, but not exclusively, nuclear.
uniprot
proteins