PSRC1
entrez
84722
canonical
uniprot
Q6PGN9
canonical
ensembl
ENSG00000134222
resolver
ensp
ENSP00000358919
resolver
ensp
ENSP00000358920
resolver
ensp
ENSP00000358923
resolver
ensp
ENSP00000358925
resolver
ensp
ENSP00000386323
resolver
ensp
ENSP00000474667
resolver
ensp
ENSP00000572425
resolver
ensp
ENSP00000572426
resolver
ensp
ENSP00000572427
resolver
ensp
ENSP00000572429
resolver
ensp
ENSP00000572430
resolver
ensp
ENSP00000572432
resolver
ensp
ENSP00000572433
resolver
ensp
ENSP00000572434
resolver
ensp
ENSP00000572436
resolver
ensp
ENSP00000572437
resolver
ensp
ENSP00000586169
resolver
ensp
ENSP00000586170
resolver
ensp
ENSP00000586177
resolver
ensp
ENSP00000586178
resolver
ensp
ENSP00000586181
resolver
ensp
ENSP00000624418
resolver
ensp
ENSP00000624420
resolver
ensp
ENSP00000672073
resolver
ensp
ENSP00000672074
resolver
ensp
ENSP00000694785
resolver
ensp
ENSP00000694787
resolver
ensp
ENSP00000746462
resolver
genesymbol
PSRC1
resolver
genesymbol_syn
DDA3
resolver
hgnc
HGNC:24472
resolver
uniprot
A8K0M8
resolver
uniprot
Q5T2Z3
resolver
uniprot
Q6ZTI8
resolver
uniprot
Q71MG3
resolver
uniprot
Q9BV77
resolver
uniprot_entry
A8K0M8_HUMAN
resolver
uniprot_entry
PSRC1_HUMAN
resolver
uniprot_sec
Q5T2Z3
resolver
uniprot_sec
Q6ZTI8
resolver
uniprot_sec
Q71MG3
resolver
uniprot_sec
Q9BV77
resolver
amino_acid_sequence
MEDLEEDVRFIVDETLDFGGLSPSDSREEEDITVLVTPEKPLRRGLSHRSDPNAVAPAPQGVRLSLGPLSPEKLEEILDEANRLAAQLEQCALQDRESAGEGLGPRRVKPSPRRETFVLKDSPVRDLLPTVNSLTRSTPSPSSLTPRLRSNDRKGSVRALRATSGKRPSNMKRESPTCNLFPASKSPASSPLTRSTPPVRGRAGPSGRAAASEETRAAKLRVSGSGEFVGLTLKFLHPSPPGPPTPIRSVLAPQPSTSNSQRLPRPQGAAAKSSSQLPIPSAIPRPASRMPLTSRSVPPGRGALPPDSLSTRKGLPRPSTAGHRVRESGHKVPVSQRLNLPVMGATRSNLQPPRKVAVPGPTR
uniprot
proteins
function
FUNCTION: Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression. {ECO:0000269|PubMed:18411309, ECO:0000269|PubMed:19738423, ECO:0000269|PubMed:26820536}.
uniprot
proteins
mass_dalton
38796
uniprot
proteins
post_translational_modification
PTM: Phosphorylated during mitosis. {ECO:0000269|PubMed:18411309}.
uniprot
proteins
protein_family
PSRC1 family
uniprot
proteins
pubmed
12427559
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18411309
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19738423
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26820536
uniprot
proteins
sequence_length
363
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=Detected at the mitotic spindle and spindle poles. Diffusely distributed throughout the cell during interphase.
uniprot
proteins