Slc2a2
entrez
20526
canonical
uniprot
P14246
canonical
ensembl
ENSMUSG00000027690
resolver
ensp
ENSMUSP00000029240
resolver
enst
ENSMUST00000029240
resolver
genesymbol
Slc2a2
resolver
genesymbol_syn
Glut2
resolver
uniprot
Q3TNA5
resolver
uniprot
Q9DBA7
resolver
uniprot_entry
GTR2_MOUSE
resolver
uniprot_sec
Q3TNA5
resolver
uniprot_sec
Q9DBA7
resolver
activity_regulation
ACTIVITY REGULATION: D-glucose and maltose competitively inhibit fructose transport. D-glucose, D-fructose and maltose inhibit deoxyglucose transport. {ECO:0000250|UniProtKB:P11168}.
uniprot
proteins
amino_acid_sequence
MSEDKITGTLAFTVFTAVLSSFQFGYDIGVINAPQEVIISHYRHVLGVPLDDRKAAINYDVNGTDTPLTVTPAYTTPAPWDEEETEGSAHIVTMLWSLSVSSFAVGGMVASFFGGWLGDKLGRIKAMLAANSLSLTGALLMGCSKFGPAHALIIAGRSVSGLYCGLISGLVPMYIGEIAPTTLRGALGTLHQLALVTGILISQIAGLSFILGNQDHWHILLGLSAVPALLQCLLLLFCPESPRYLYIKLEEEVRAKKSLKRLRGTEDVTKDINEMKKEKEEASTEQKVSVIQLFTDANYRQPILVALMLHMAQQFSGINGIFYYSTSIFQTAGISQPVYATIGVGAINMIFTAVSVLLVEKAGRRTLFLTGMIGMFFCTIFMSVGLVLLDKFAWMSYVSMTAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRPTALALAAFSNWVCNFVIALCFQYIADFLGPYVFFLFAGVVLVFTLFTFFKVPETKGKSFEEIAAEFRKKSGSAPPRKAAVQMEFLASSESV
uniprot
proteins
function
FUNCTION: Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose. Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of beta cells. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. Also able to mediate the transport of dehydroascorbate and urate. {ECO:0000250|UniProtKB:P11168}.
uniprot
proteins
mass_dalton
57107
uniprot
proteins
post_translational_modification
PTM: N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells. {ECO:0000269|PubMed:16377570}.
uniprot
proteins
protein_family
Glucose transporter subfamily
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Sugar transporter (TC 2.A.1.1) family
uniprot
proteins
pubmed
1289053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16377570
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
1765007
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2602116
uniprot
proteins
pubmed
2771649
uniprot
proteins
pubmed
7929431
uniprot
proteins
sequence_length
523
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P11168}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 11..31; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 98..118; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 127..147; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 158..178; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 187..207; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 217..237; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 303..323; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 338..358; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 368..388; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 402..422; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 433..453; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 461..481; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins