ORMDL1
entrez
94101
canonical
uniprot
Q9P0S3
canonical
ensembl
ENSG00000128699
resolver
ensp
ENSP00000326869
resolver
ensp
ENSP00000376160
resolver
ensp
ENSP00000376161
resolver
ensp
ENSP00000402074
resolver
ensp
ENSP00000407234
resolver
ensp
ENSP00000520902
resolver
ensp
ENSP00000523805
resolver
ensp
ENSP00000523806
resolver
ensp
ENSP00000523807
resolver
ensp
ENSP00000523808
resolver
ensp
ENSP00000523809
resolver
ensp
ENSP00000523810
resolver
ensp
ENSP00000523811
resolver
ensp
ENSP00000523812
resolver
ensp
ENSP00000523814
resolver
ensp
ENSP00000523816
resolver
ensp
ENSP00000523817
resolver
ensp
ENSP00000523818
resolver
ensp
ENSP00000523819
resolver
ensp
ENSP00000523820
resolver
ensp
ENSP00000523821
resolver
ensp
ENSP00000523822
resolver
ensp
ENSP00000523823
resolver
ensp
ENSP00000523824
resolver
ensp
ENSP00000523825
resolver
ensp
ENSP00000591351
resolver
ensp
ENSP00000591352
resolver
ensp
ENSP00000591353
resolver
ensp
ENSP00000591354
resolver
ensp
ENSP00000591356
resolver
ensp
ENSP00000591357
resolver
ensp
ENSP00000591358
resolver
ensp
ENSP00000591359
resolver
ensp
ENSP00000591360
resolver
ensp
ENSP00000631305
resolver
ensp
ENSP00000631306
resolver
ensp
ENSP00000631307
resolver
ensp
ENSP00000631310
resolver
ensp
ENSP00000631311
resolver
ensp
ENSP00000673702
resolver
ensp
ENSP00000708157
resolver
enst
ENST00000325795
resolver
enst
ENST00000392349
resolver
enst
ENST00000392350
resolver
enst
ENST00000850615
resolver
enst
ENST00000853746
resolver
enst
ENST00000853747
resolver
enst
ENST00000853748
resolver
enst
ENST00000853749
resolver
enst
ENST00000853750
resolver
enst
ENST00000853751
resolver
enst
ENST00000853752
resolver
enst
ENST00000853753
resolver
enst
ENST00000853755
resolver
enst
ENST00000853757
resolver
enst
ENST00000853758
resolver
enst
ENST00000853759
resolver
enst
ENST00000853760
resolver
enst
ENST00000853761
resolver
enst
ENST00000853762
resolver
enst
ENST00000853763
resolver
enst
ENST00000853764
resolver
enst
ENST00000853765
resolver
enst
ENST00000853766
resolver
enst
ENST00000921292
resolver
enst
ENST00000921293
resolver
enst
ENST00000921294
resolver
enst
ENST00000921295
resolver
enst
ENST00000921297
resolver
enst
ENST00000921298
resolver
enst
ENST00000921299
resolver
enst
ENST00000921300
resolver
enst
ENST00000921301
resolver
enst
ENST00000961246
resolver
enst
ENST00000961247
resolver
enst
ENST00000961248
resolver
enst
ENST00000961251
resolver
enst
ENST00000961252
resolver
genesymbol
ORMDL1
resolver
hgnc
HGNC:16036
resolver
uniprot
A0ABB0MVM0
resolver
uniprot
B2R8W3
resolver
uniprot
D3DPH9
resolver
uniprot_entry
A0ABB0MVM0_HUMAN
resolver
uniprot_entry
ORML1_HUMAN
resolver
uniprot_sec
B2R8W3
resolver
uniprot_sec
D3DPH9
resolver
amino_acid_sequence
MNVGVAHSEVNPNTRVMNSRGMWLTYALGVGLLHIVLLSIPFFSVPVAWTLTNIIHNLGMYVFLHAVKGTPFETPDQGKARLLTHWEQLDYGVQFTSSRKFFTISPIILYFLASFYTKYDPTHFILNTASLLSVLIPKMPQLHGVRIFGINKY
uniprot
proteins
function
FUNCTION: Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels (PubMed:20182505). When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis (By similarity). {ECO:0000250|UniProtKB:Q8N138, ECO:0000269|PubMed:20182505}.
uniprot
proteins
mass_dalton
17371
uniprot
proteins
protein_family
ORM family
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
12093374
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17928364
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
20182505
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
153
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12093374}; Multi-pass membrane protein {ECO:0000269|PubMed:12093374}.
uniprot
proteins
transmembrane_region
TRANSMEM 27..46; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 47..64; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 101..121; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 124..140; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins