Lef1
entrez
16842
canonical
uniprot
P27782
canonical
ensembl
ENSMUSG00000027985
resolver
ensp
ENSMUSP00000029611
resolver
ensp
ENSMUSP00000067808
resolver
ensp
ENSMUSP00000096211
resolver
ensp
ENSMUSP00000101948
resolver
ensp
ENSMUSP00000313029
resolver
enst
ENSMUST00000066849
resolver
enst
ENSMUST00000098611
resolver
enst
ENSMUST00000106341
resolver
genesymbol
Lef1
resolver
uniprot
D3Z654
resolver
uniprot
F6Q114
resolver
uniprot
F7CSD7
resolver
uniprot
Q3TYB0
resolver
uniprot
Q8BGZ9
resolver
uniprot
Q8C402
resolver
uniprot_entry
D3Z654_MOUSE
resolver
uniprot_entry
F6Q114_MOUSE
resolver
uniprot_entry
F7CSD7_MOUSE
resolver
uniprot_entry
LEF1_MOUSE
resolver
uniprot_entry
Q3TYB0_MOUSE
resolver
uniprot_entry
Q8BGZ9_MOUSE
resolver
uniprot_entry
Q8C402_MOUSE
resolver
amino_acid_sequence
MPQLSGGGGGGDPELCATDEMIPFKDEGDPQKEKIFAEISHPEEEGDLADIKSSLVNESEIIPASNGHEVVRQAPSSQEPYHDKAREHPDEGKHPDGGLYNKGPSYSSYSGYIMMPNMNSDPYMSNGSLSPPIPRTSNKVPVVQPSHAVHPLTPLITYSDEHFSPGSHPSHIPSDVNSKQGMSRHPPAPEIPTFYPLSPGGVGQITPPIGWQGQPVYPITGGFRQPYPSSLSGDTSMSRFSHHMIPGPPGPHTTGIPHPAIVTPQVKQEHPHTDSDLMHVKPQHEQRKEQEPKRPHIKKPLNAFMLYMKEMRANVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKREKLQESTSGTGPRMTAAYI
uniprot
proteins
function
FUNCTION: Transcription factor that binds DNA in a sequence-specific manner (By similarity). Participates in the Wnt signaling pathway (PubMed:11445543). Activates transcription of target genes in the presence of CTNNB1 and EP300 (PubMed:12446687). PIASG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (PubMed:11731474). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1 (By similarity). Regulates T-cell receptor alpha enhancer function (By similarity). Required for IL17A expressing gamma-delta T-cell maturation and development, via binding to regulator loci of BLK to modulate expression (PubMed:23562159). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (PubMed:29148101). May play a role in hair cell differentiation and follicle morphogenesis (PubMed:11445543). {ECO:0000250|UniProtKB:Q9UJU2, ECO:0000269|PubMed:11445543, ECO:0000269|PubMed:11731474, ECO:0000269|PubMed:12446687, ECO:0000269|PubMed:23562159, ECO:0000269|PubMed:29148101}.
uniprot
proteins
mass_dalton
44059
uniprot
proteins
mutagenesis
MUTAGEN 19; /note="D->A: Strongly diminishes CTNNB1 binding and transactivation. Prevents nuclear translocation of CTNNB1."; /evidence="ECO:0000269|PubMed:10966653"; MUTAGEN 20; /note="E->A: Prevents nuclear translocation of CTNNB1."; /evidence="ECO:0000269|PubMed:10966653"; MUTAGEN 24; /note="F->A: Strongly diminishes CTNNB1 binding and transactivation. Prevents nuclear translocation of CTNNB1."; /evidence="ECO:0000269|PubMed:10966653"; MUTAGEN 26; /note="D->A: Prevents nuclear translocation of CTNNB1."; /evidence="ECO:0000269|PubMed:10966653"; MUTAGEN 27; /note="E->A: Prevents nuclear translocation of CTNNB1."; /evidence="ECO:0000269|PubMed:10966653
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Thr-153 and/or Ser-164 by NLK (By similarity). Phosphorylation by NLK at these sites represses LEF1-mediated transcriptional activation of target genes of the canonical Wnt signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q9UJU2}.
uniprot
proteins
protein_family
TCF/LEF family
uniprot
proteins
pubmed
10498690
uniprot
proteins
pubmed
10966653
uniprot
proteins
pubmed
11445543
uniprot
proteins
pubmed
11731474
uniprot
proteins
pubmed
12446687
uniprot
proteins
pubmed
17218525
uniprot
proteins
pubmed
1827423
uniprot
proteins
pubmed
19304756
uniprot
proteins
pubmed
23562159
uniprot
proteins
pubmed
27713059
uniprot
proteins
pubmed
29148101
uniprot
proteins
pubmed
7651541
uniprot
proteins
pubmed
8415007
uniprot
proteins
pubmed
8898217
uniprot
proteins
sequence_length
397
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10498690}. Note=Found in nuclear bodies upon PIASG binding.
uniprot
proteins