CHRNA10
entrez
57053
canonical
uniprot
Q9GZZ6
canonical
ensembl
ENSG00000129749
resolver
ensp
ENSP00000250699
resolver
enst
ENST00000250699
resolver
genesymbol
CHRNA10
resolver
genesymbol_syn
NACHRA10
resolver
hgnc
HGNC:13800
resolver
uniprot
C4IXS7
resolver
uniprot_entry
ACH10_HUMAN
resolver
uniprot_entry
C4IXS7_HUMAN
resolver
activity_regulation
ACTIVITY REGULATION: Activated by a myriad of ligands such as acetylcholine (PubMed:11752216). AChR activity is inhibited by the antagonists alpha-conotoxins RgIA and GeXXA, small disulfide-constrained peptides from cone snails (PubMed:26395518). {ECO:0000269|PubMed:11752216, ECO:0000269|PubMed:26395518}.
uniprot
proteins
amino_acid_sequence
MGLRSHHLSLGLLLLFLLPAECLGAEGRLALKLFRDLFANYTSALRPVADTDQTLNVTLEVTLSQIIDMDERNQVLTLYLWIRQEWTDAYLRWDPNAYGGLDAIRIPSSLVWRPDIVLYNKADAQPPGSASTNVVLRHDGAVRWDAPAITRSSCRVDVAAFPFDAQHCGLTFGSWTHGGHQLDVRPRGAAASLADFVENVEWRVLGMPARRRVLTYGCCSEPYPDVTFTLLLRRRAAAYVCNLLLPCVLISLLAPLAFHLPADSGEKVSLGVTVLLALTVFQLLLAESMPPAESVPLIGKYYMATMTMVTFSTALTILIMNLHYCGPSVRPVPAWARALLLGHLARGLCVRERGEPCGQSRPPELSPSPQSPEGGAGPPAGPCHEPRCLCRQEALLHHVATIANTFRSHRAAQRCHEDWKRLARVMDRFFLAIFFSMALVMSLLVLVQAL
uniprot
proteins
function
FUNCTION: Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (Probable). Forms heteropentamers with CHRNA9. Expressed in the inner ear, in sympathetic neurons and in other non-neuronal cells, such as skin keratinocytes and lymphocytes (PubMed:11752216, PubMed:15531379). nAChR formed by CHRNA9:CHRNA10 is involved in modulation of auditory stimuli. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, mediates synaptic transmission between efferent olivocochlear fibers and hair cells of the cochlea, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing (PubMed:11752216). This may protect against acoustic trauma. May also regulate keratinocyte adhesion (By similarity). {ECO:0000250|UniProtKB:Q9UGM1, ECO:0000269|PubMed:11752216, ECO:0000269|PubMed:15531379, ECO:0000305|PubMed:18723036}.
uniprot
proteins
mass_dalton
49705
uniprot
proteins
mutagenesis
MUTAGEN 31; /note="L->H: 11-fold increase in inhibition of the AChR composed of subunits CHRNA9 and CHRNA10 by the conotoxin GEXXA, and no change in activity on mAChR composed of subunits CHRNA9 and CHRNA10 by the competitive conotoxin Vc1A."; /evidence="ECO:0000269|PubMed:26395518
uniprot
proteins
protein_family
Acetylcholine receptor (TC 1.A.9.1) subfamily
uniprot
proteins
protein_family
Alpha-10/CHRNA10 sub-subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
11350119
uniprot
proteins
pubmed
11752216
uniprot
proteins
pubmed
15531379
uniprot
proteins
pubmed
18723036
uniprot
proteins
pubmed
26395518
uniprot
proteins
sequence_length
450
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Synaptic cell membrane {ECO:0000250|UniProtKB:Q9JLB5}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9JLB5}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 238..258; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 268..288; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 302..322; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 429..449; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins