Chmp2b
entrez
68942
canonical
uniprot
Q8BJF9
canonical
ensembl
ENSMUSG00000004843
resolver
ensp
ENSMUSP00000004965
resolver
ensp
ENSMUSP00000156381
resolver
enst
ENSMUST00000004965
resolver
enst
ENSMUST00000231259
resolver
genesymbol
Chmp2b
resolver
uniprot
A0A338P7L8
resolver
uniprot
Q80UZ4
resolver
uniprot
Q9CT65
resolver
uniprot_entry
A0A338P7L8_MOUSE
resolver
uniprot_entry
CHM2B_MOUSE
resolver
uniprot_sec
Q80UZ4
resolver
uniprot_sec
Q9CT65
resolver
amino_acid_sequence
MASLFKKKTVDDVIKEQNRELRGTQRAIIRDRAALEKQEKQLELEIKKMAKIGNKEACRVLAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQKTLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMAKAPSAARSLPSASTSKATISDEEIERQLKALGVD
uniprot
proteins
function
FUNCTION: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4 (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
23935
uniprot
proteins
protein_family
SNF7 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16041373
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
213
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Late endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
uniprot
proteins