LYPD8
entrez
646627
canonical
uniprot
Q6UX82
canonical
ensembl
ENSG00000259823
resolver
ensp
ENSP00000466070
resolver
ensp
ENSP00000547267
resolver
ensp
ENSP00000547268
resolver
ensp
ENSP00000631546
resolver
ensp
ENSP00000631547
resolver
ensp
ENSP00000631549
resolver
ensp
ENSP00000668568
resolver
enst
ENST00000590317
resolver
enst
ENST00000877208
resolver
enst
ENST00000877209
resolver
enst
ENST00000961487
resolver
enst
ENST00000961488
resolver
enst
ENST00000961490
resolver
genesymbol
LYPD8
resolver
hgnc
HGNC:44208
resolver
uniprot
A0A075B722
resolver
uniprot
K7ELG6
resolver
uniprot_entry
LYPD8_HUMAN
resolver
uniprot_sec
A0A075B722
resolver
uniprot_sec
K7ELG6
resolver
amino_acid_sequence
MKGILVAGITAVLVAAVESLSCVQCNSWEKSCVNSIASECPSHANTSCISSSASSSLETPVRLYQNMFCSAENCSEETHITAFTVHVSAEEHFHFVSQCCQGKECSNTSDALDPPLKNVSSNAECPACYESNGTSCHGKPWKCYEEEQCVFLVAELKNDIESKSLVLKGCSNVSNATCQFLSGENKTLGGVIFRKFECANVNSLTPTSAPTTSHNVGSKASLYLLALASLLLRGLLP
uniprot
proteins
function
FUNCTION: Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis. {ECO:0000250|UniProtKB:Q9D7S0}.
uniprot
proteins
mass_dalton
25265
uniprot
proteins
post_translational_modification
PTM: Highly N-glycosylated. Not O-glycosylated. {ECO:0000250|UniProtKB:Q9D7S0}.; PTM: GPI-anchored. The GPI-anchor is cleaved, leading to secretion into the colonic lumen. {ECO:0000250|UniProtKB:Q9D7S0}.
uniprot
proteins
protein_family
CNF-like-inhibitor family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
27027293
uniprot
proteins
sequence_length
237
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9D7S0}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q9D7S0}. Secreted {ECO:0000250|UniProtKB:Q9D7S0}. Note=Secreted into the lumen of the colon following cleavage of the GPI-anchor. {ECO:0000250|UniProtKB:Q9D7S0}.
uniprot
proteins