Purb
entrez
19291
canonical
uniprot
O35295
canonical
ensembl
ENSMUSG00000094483
resolver
ensp
ENSMUSP00000136957
resolver
enst
ENSMUST00000179343
resolver
genesymbol
Purb
resolver
uniprot_entry
PURB_MOUSE
resolver
amino_acid_sequence
MADGDSGSERGGGGGGGGGPGGFQPAPRGGGGGGGGPGGEQETQELASKRLDIQNKRFYLDVKQNAKGRFLKIAEVGAGGSKSRLTLSMAVAAEFRDSLGDFIEHYAQLGPSSPEQLAAGAEEGGGPRRALKSEFLVRENRKYYLDLKENQRGRFLRIRQTVNRGGGGFGGGPGPGGLQSGQTIALPAQGLIEFRDALAKLIDDYGGDEDELAGGPGGGAGGPGGGLYGELPEGTSITVDSKRFFFDVGCNKYGVFLRVSEVKPSYRNAITVPFKAWGKFGGAFCRYADEMKEIQERQRDKLYERRGGGSGGGDESEGEEVDED
uniprot
proteins
function
FUNCTION: Transcriptional regulator which can act as an activator or a repressor (PubMed:11751932, PubMed:12874279, PubMed:27064749, PubMed:31918924, PubMed:33743134, PubMed:9334258). Represses the transcription of ACTA2 in fibroblasts and smooth muscle cells via its ability to interact with the purine-rich strand of a MCAT-containing element in the 5' flanking region of the gene (PubMed:11751932, PubMed:12874279, PubMed:27064749, PubMed:9334258). Represses the transcription of MYOCD, capable of repressing all isoforms of MYOCD but the magnitude of the repressive effects is most notable for the SMC-specific isoforms (PubMed:33743134). Promotes hepatic glucose production by activating the transcription of ADCY6, leading to cAMP accumulation, increased PKA activity, CREB activation, and increased transcription of PCK1 and G6PC genes (PubMed:31918924). Has capacity to bind repeated elements in single-stranded DNA such as the purine-rich single strand of the PUR element located upstream of the MYC gene (By similarity). Participates in transcriptional and translational regulation of alpha-MHC expression in cardiac myocytes by binding to the purine-rich negative regulatory (PNR) element (By similarity). Modulates constitutive liver galectin-3 gene transcription by binding to its promoter (By similarity). May play a role in the dendritic transport of a subset of mRNAs (By similarity). {ECO:0000250|UniProtKB:Q68A21, ECO:0000250|UniProtKB:Q96QR8, ECO:0000269|PubMed:11751932, ECO:0000269|PubMed:12874279, ECO:0000269|PubMed:27064749, ECO:0000269|PubMed:31918924, ECO:0000269|PubMed:33743134, ECO:0000269|PubMed:9334258}.
uniprot
proteins
mass_dalton
33901
uniprot
proteins
mutagenesis
MUTAGEN 82; /note="K->A: Reduced transcriptional repression of ACTA2 and MYOCD. No effect on homodimerization and thermal stability. Reduced ssDNA-binding and interaction with MSY1; when associated with A-159 and A-267."; /evidence="ECO:0000269|PubMed:27064749, ECO:0000269|PubMed:33743134"; MUTAGEN 159; /note="R->A: Reduced transcriptional repression of ACTA2 and MYOCD. No effect on homodimerization and thermal stability. Reduced ssDNA-binding and interaction with MSY1; when associated with A-82 and A-267."; /evidence="ECO:0000269|PubMed:27064749, ECO:0000269|PubMed:33743134"; MUTAGEN 215; /note="G->S: Reduced transcriptional repression of MYOCD."; /evidence="ECO:0000269|PubMed:33743134"; MUTAGEN 223; /note="P->L: Reduced transcriptional repression of MYOCD."; /evidence="ECO:0000269|PubMed:33743134"; MUTAGEN 267; /note="R->A: Reduced transcriptional repression of ACTA2 and MYOCD and ssDNA-binding. No effect on homodimerization and thermal stability. Increased interaction with MSY1. Reduced ssDNA-binding and interaction with MSY1; when associated with A-82 and A-159."; /evidence="ECO:0000269|PubMed:27064749, ECO:0000269|PubMed:33743134"; MUTAGEN 297; /note="R->Q: Reduced transcriptional repression of MYOCD."; /evidence="ECO:0000269|PubMed:33743134
uniprot
proteins
protein_family
PUR DNA-binding protein family
uniprot
proteins
pubmed
10318844
uniprot
proteins
pubmed
11751932
uniprot
proteins
pubmed
12874279
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
27064749
uniprot
proteins
pubmed
31918924
uniprot
proteins
pubmed
33743134
uniprot
proteins
pubmed
9334258
uniprot
proteins
sequence_length
324
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:33743134}.
uniprot
proteins