FDPS
entrez
2224
canonical
uniprot
P14324
canonical
ensembl
ENSG00000160752
resolver
ensp
ENSP00000349078
resolver
ensp
ENSP00000357340
resolver
ensp
ENSP00000391755
resolver
ensp
ENSP00000478235
resolver
ensp
ENSP00000480142
resolver
ensp
ENSP00000483188
resolver
enst
ENST00000611010
resolver
genesymbol
FDPS
resolver
genesymbol_syn
FPS
resolver
genesymbol_syn
KIAA1293
resolver
hgnc
HGNC:3631
resolver
uniprot
A0A087X090
resolver
uniprot
D3DV91
resolver
uniprot
E9PCI9
resolver
uniprot
Q96G29
resolver
uniprot_entry
A0A087X090_HUMAN
resolver
uniprot_entry
FPPS_HUMAN
resolver
uniprot_sec
D3DV91
resolver
uniprot_sec
E9PCI9
resolver
uniprot_sec
Q96G29
resolver
activity_regulation
ACTIVITY REGULATION: Inactivated by interferon-induced RSAD2. This inactivation may result of disruption of lipid rafts at the plasma membrane, and thus have an antiviral effect since many enveloped viruses need lipid rafts to bud efficiently out of the cell. {ECO:0000269|PubMed:18005724}.
uniprot
proteins
amino_acid_sequence
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRALCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
uniprot
proteins
disease_involvement
DISEASE: Porokeratosis 9, multiple types (POROK9) [MIM:616631]: A form of porokeratosis, a disorder of faulty keratinization characterized by one or more atrophic patches surrounded by a distinctive hyperkeratotic ridgelike border called the cornoid lamella. The keratotic lesions can progress to overt cutaneous neoplasms, typically squamous cell carcinomas. Multiple clinical variants of porokeratosis are recognized, including porokeratosis of Mibelli, linear porokeratosis, disseminated superficial actinic porokeratosis, palmoplantar porokeratosis, and punctate porokeratosis. Different clinical presentations can be observed among members of the same family. Individuals expressing more than one variant have also been reported. {ECO:0000269|PubMed:26202976}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.5.1.1
uniprot
proteins
ec_number
2.5.1.10
uniprot
proteins
function
FUNCTION: Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
uniprot
proteins
mass_dalton
48275
uniprot
proteins
pathway_participation
PATHWAY: Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.; PATHWAY: Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.
uniprot
proteins
protein_family
FPP/GGPP synthase family
uniprot
proteins
pubmed
11773414
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15827605
uniprot
proteins
pubmed
16684881
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16892359
uniprot
proteins
pubmed
18005724
uniprot
proteins
pubmed
19309137
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
1968462
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26202976
uniprot
proteins
pubmed
2690933
uniprot
proteins
pubmed
29192674
uniprot
proteins
pubmed
7584026
uniprot
proteins
sequence_length
419
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins