Fut2
entrez
14344
canonical
uniprot
Q9JL27
canonical
ensembl
ENSMUSG00000055978
resolver
ensp
ENSMUSP00000063719
resolver
ensp
ENSMUSP00000170107
resolver
enst
ENSMUST00000069800
resolver
genesymbol
Fut2
resolver
genesymbol_syn
Sec2
resolver
uniprot
A6H6C9
resolver
uniprot
O70504
resolver
uniprot_entry
A6H6C9_MOUSE
resolver
uniprot_entry
FUT2_MOUSE
resolver
uniprot_sec
O70504
resolver
amino_acid_sequence
MASAQVPFSFPLAHFLIFVFVTSTIIHLQQRIVKLQTLSEKELQAVQMSSPNAARTDMQQSAKLQGIFTINSIGRLGNQMGEYATLFALARMNGRLAFIPESMHNALAPIFRISLPVLHSDTARRIPWQNYHLNDWMEERYRHIPGQYVRFTGYPCSWTFYHHLRPEILKEFTLHDHVREEAQAFLRGLRVNGSQPSTFVGVHVRRGDYVHVMPKVWKGVVADRGYLEKALDRFRARYSSPVFVVTSNGMAWCRENINTSLGDVVFAGNGIEGSPAKDFALLTQCNHTIMTIGTFGIWAAYLAGGDTIYLANYTLPDSPFLKIFKPAAAFLPEWMGIPADLSPLLKH
uniprot
proteins
ec_number
2.4.1.344
uniprot
proteins
ec_number
2.4.1.69
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation (PubMed:11018479, PubMed:11323419, PubMed:11368156, PubMed:14967068, PubMed:19706747, PubMed:27161092). Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs (PubMed:11713270, PubMed:14967068). Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition (PubMed:19706747, PubMed:27161092). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:11323419). {ECO:0000269|PubMed:11018479, ECO:0000269|PubMed:11323419, ECO:0000269|PubMed:11368156, ECO:0000269|PubMed:11713270, ECO:0000269|PubMed:14967068, ECO:0000269|PubMed:19706747, ECO:0000269|PubMed:27161092}.
uniprot
proteins
mass_dalton
39243
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:11323419}.
uniprot
proteins
protein_family
Glycosyltransferase 11 family
uniprot
proteins
pubmed
11018479
uniprot
proteins
pubmed
11323419
uniprot
proteins
pubmed
11368156
uniprot
proteins
pubmed
11713270
uniprot
proteins
pubmed
14967068
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19706747
uniprot
proteins
pubmed
24284406
uniprot
proteins
pubmed
27161092
uniprot
proteins
sequence_length
347
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Note=Membrane-bound form in trans cisternae of Golgi. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 6..26; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins