E2F4
entrez
1874
canonical
uniprot
Q16254
canonical
ensembl
ENSG00000205250
resolver
ensp
ENSP00000368686
resolver
enst
ENST00000379378
resolver
genesymbol
E2F4
resolver
hgnc
HGNC:3118
resolver
uniprot
A6NGR8
resolver
uniprot
B5BU56
resolver
uniprot
Q12991
resolver
uniprot
Q15328
resolver
uniprot_entry
E2F4_HUMAN
resolver
uniprot_sec
A6NGR8
resolver
uniprot_sec
B5BU56
resolver
uniprot_sec
Q12991
resolver
uniprot_sec
Q15328
resolver
amino_acid_sequence
MAEAGPQAPPPPGTPSRHEKSLGLLTTKFVSLLQEAKDGVLDLKLAADTLAVRQKRRIYDITNVLEGIGLIEKKSKNSIQWKGVGPGCNTREIADKLIELKAEIEELQQREQELDQHKVWVQQSIRNVTEDVQNSCLAYVTHEDICRCFAGDTLLAIRAPSGTSLEVPIPEGLNGQKKYQIHLKSVSGPIEVLLVNKEAWSSPPVAVPVPPPEDLLQSPSAVSTPPPLPKPALAQSQEASRPNSPQLTPTAVPGSAEVQGMAGPAAEITVSGGPGTDSKDSGELSSLPLGPTTLDTRPLQSSALLDSSSSSSSSSSSSSNSNSSSSSGPNPSTSFEPIKADPTGVLELPKELSEIFDPTRECMSSELLEELMSSEVFAPLLRLSPPPGDHDYIYNLDESEGVCDLFDVPVLNL
uniprot
proteins
function
FUNCTION: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F4 binds with high affinity to RBL1 and RBL2. In some instances can also bind RB1. Specifically required for multiciliate cell differentiation: together with MCIDAS and E2F5, binds and activate genes required for centriole biogenesis. {ECO:0000250|UniProtKB:Q6DE14, ECO:0000269|PubMed:7958924, ECO:0000269|PubMed:7958925}.
uniprot
proteins
mass_dalton
43960
uniprot
proteins
post_translational_modification
PTM: Differentially phosphorylated in vivo.
uniprot
proteins
protein_family
E2F/DP family
uniprot
proteins
pubmed
10090723
uniprot
proteins
pubmed
10679953
uniprot
proteins
pubmed
10797289
uniprot
proteins
pubmed
11418595
uniprot
proteins
pubmed
14532282
uniprot
proteins
pubmed
15107404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
16360038
uniprot
proteins
pubmed
17531812
uniprot
proteins
pubmed
17671431
uniprot
proteins
pubmed
19054851
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
22002537
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
7892279
uniprot
proteins
pubmed
7958924
uniprot
proteins
pubmed
7958925
uniprot
proteins
pubmed
9074408
uniprot
proteins
sequence_length
413
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins