Aspn
entrez
66695
canonical
uniprot
Q99MQ4
canonical
ensembl
ENSMUSG00000021388
resolver
ensp
ENSMUSP00000021820
resolver
ensp
ENSMUSP00000136728
resolver
enst
ENSMUST00000021820
resolver
enst
ENSMUST00000177948
resolver
genesymbol
Aspn
resolver
uniprot
A6H6K1
resolver
uniprot
Q9D6A2
resolver
uniprot_entry
A6H6K1_MOUSE
resolver
uniprot_entry
ASPN_MOUSE
resolver
uniprot_sec
Q9D6A2
resolver
amino_acid_sequence
MKEYVMLLLLAVCSAKPFFSPSHTALKNMMLKDMEDTDDDDNDDDDNSLFPTKEPVNPFFPFDLFPTCPFGCQCYSRVVHCSDLGLTSVPNNIPFDTRMVDLQNNKIKEIKENDFKGLTSLYALILNNNKLTKIHPKTFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHDNKVKKIQKDTFKGMNALHVLEMSANPLENNGIEPGAFEGVTVFHIRIAEAKLTSIPKGLPPTLLELHLDFNKISTVELEDLKRYRELQRLGLGNNRITDIENGTFANIPRVREIHLEHNKLKKIPSGLQELKYLQIIFLHYNSIAKVGVNDFCPTVPKMKKSLYSAISLFNNPMKYWEIQPATFRCVLGRMSVQLGNVGK
uniprot
proteins
function
FUNCTION: Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor, resulting in inhibition of BMP-dependent activation of SMAD proteins. Inhibits the interaction between TGFB1 and TGF-beta receptor type II in the presence of heparin/heparan sulfate in vitro. {ECO:0000250, ECO:0000269|PubMed:17522060, ECO:0000269|PubMed:17827158, ECO:0000269|PubMed:18407830, ECO:0000269|PubMed:20052601}.
uniprot
proteins
mass_dalton
42573
uniprot
proteins
mutagenesis
MUTAGEN 170; /note="R->E: Partial inhibition of BMP2-induced cytodifferentiation; when associated with E-219."; /evidence="ECO:0000269|PubMed:18407830"; MUTAGEN 194; /note="E->G,K: Rescues the inhibitory effects of ASPN on BMP2-induced cytodifferentiation."; /evidence="ECO:0000269|PubMed:18407830"; MUTAGEN 219; /note="R->E: Partial inhibition of BMP2-induced cytodifferentiation; when associated with E-170."; /evidence="ECO:0000269|PubMed:18407830
uniprot
proteins
protein_family
SLRP class I subfamily
uniprot
proteins
protein_family
Small leucine-rich proteoglycan (SLRP) family
uniprot
proteins
pubmed
11152692
uniprot
proteins
pubmed
11152695
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17522060
uniprot
proteins
pubmed
17804408
uniprot
proteins
pubmed
17827158
uniprot
proteins
pubmed
18407830
uniprot
proteins
pubmed
20052601
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
uniprot
proteins