Cd8a
entrez
12525
canonical
uniprot
P01731
canonical
ensembl
ENSMUSG00000053977
resolver
ensp
ENSMUSP00000068123
resolver
ensp
ENSMUSP00000131873
resolver
enst
ENSMUST00000066747
resolver
enst
ENSMUST00000172321
resolver
genesymbol
Cd8a
resolver
genesymbol_syn
Lyt-2
resolver
genesymbol_syn
Lyt2
resolver
uniprot
F6ZKS7
resolver
uniprot
Q8CAX3
resolver
uniprot_entry
CD8A_MOUSE
resolver
uniprot_entry
F6ZKS7_MOUSE
resolver
uniprot_entry
Q8CAX3_MOUSE
resolver
amino_acid_sequence
MASPLTRFLSLNLLLLGESIILGSGEAKPQAPELRIFPKKMDAELGQKVDLVCEVLGSVSQGCSWLFQNSSSKLPQPTFVVYMASSHNKITWDEKLNSSKLFSAMRDTNNKYVLTLNKFSKENEGYYFCSVISNSVMYFSSVVPVLQKVNSTTTKPVLRTPSPVHPTGTSQPQRPEDCRPRGSVKGTGLDFACDIYIWAPLAGICVALLLSLIITLICYHRSRKRVCKCPRPLVRQEGKPRPSEKIV
uniprot
proteins
function
FUNCTION: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells. {ECO:0000250|UniProtKB:P01732, ECO:0000269|PubMed:15105501, ECO:0000269|PubMed:1673361}.
uniprot
proteins
mass_dalton
27456
uniprot
proteins
post_translational_modification
PTM: Palmitoylated, but association with CD8B seems to be more important for the enrichment of CdD8A in lipid rafts. {ECO:0000250|UniProtKB:P01732}.; PTM: Phosphorylated in cytotoxic T-lymphocytes (CTLs) following activation. {ECO:0000269|PubMed:2512251}.
uniprot
proteins
pubmed
15105501
uniprot
proteins
pubmed
1673361
uniprot
proteins
pubmed
18929574
uniprot
proteins
pubmed
2512251
uniprot
proteins
pubmed
3267233
uniprot
proteins
pubmed
3487583
uniprot
proteins
pubmed
3495785
uniprot
proteins
pubmed
3927298
uniprot
proteins
pubmed
3935316
uniprot
proteins
pubmed
9806638
uniprot
proteins
sequence_length
247
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P01732}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P01732}. Note=Cd8a localizes to lipid rafts only when associated with its partner Cd8b. {ECO:0000250|UniProtKB:P01732}.
uniprot
proteins
transmembrane_region
TRANSMEM 197..217; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins