Nmb
entrez
68039
canonical
uniprot
Q9CR53
canonical
ensembl
ENSMUSG00000025723
resolver
ensp
ENSMUSP00000026817
resolver
ensp
ENSMUSP00000113407
resolver
enst
ENSMUST00000026817
resolver
enst
ENSMUST00000119428
resolver
genesymbol
Nmb
resolver
uniprot
D3Z621
resolver
uniprot_entry
D3Z621_MOUSE
resolver
uniprot_entry
NMB_MOUSE
resolver
amino_acid_sequence
MTRQAGSSWLLRGLLLFALFASGVAPFNWDLPEPRSRASKIRVHPRGNLWATGHFMGKKSLEPPSLSLVGTAPPNTPRDQRLQLSHDLLRILLRKKALGMNFSGPAPPIQYRRLLEPLLQK
uniprot
proteins
function
FUNCTION: Stimulates smooth muscle contraction (By similarity). Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (PubMed:26855425). Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (PubMed:34133943). These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneeze reflex (PubMed:34133943). Contributes to induction of acute itch, possibly through activation of the NMBR receptor on dorsal root ganglion neurons (PubMed:30734045). Increases expression of NMBR and steroidogenic mediators STAR, CYP11A1 and HSD3B1 in Leydig cells, induces secretion of testosterone by Leydig cells and also promotes Leydig cell proliferation (By similarity). Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (PubMed:31601264). Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (PubMed:28780306). {ECO:0000250|UniProtKB:P01297, ECO:0000269|PubMed:26855425, ECO:0000269|PubMed:28780306, ECO:0000269|PubMed:30734045, ECO:0000269|PubMed:31601264, ECO:0000269|PubMed:34133943}.
uniprot
proteins
mass_dalton
13571
uniprot
proteins
protein_family
Bombesin/neuromedin-B/ranatensin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
26855425
uniprot
proteins
pubmed
28780306
uniprot
proteins
pubmed
30734045
uniprot
proteins
pubmed
31601264
uniprot
proteins
pubmed
34133943
uniprot
proteins
sequence_length
121
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:34133943}. Cell projection, neuron projection {ECO:0000269|PubMed:26855425}. Note=In neurons of the retrotrapezoid nucleus//parafacial respiratory group, expressed on neuron projections which project into the pre-Botzinger complex. {ECO:0000269|PubMed:26855425}.
uniprot
proteins