GCSAM
entrez
257144
canonical
uniprot
Q8N6F7
canonical
ensembl
ENSG00000174500
resolver
ensembl
ENSG00000284925
resolver
ensp
ENSP00000309487
resolver
ensp
ENSP00000418849
resolver
ensp
ENSP00000419485
resolver
ensp
ENSP00000419913
resolver
ensp
ENSP00000420603
resolver
genesymbol
GCSAM
resolver
genesymbol_syn
GAL
resolver
genesymbol_syn
GCET2
resolver
hgnc
HGNC:20253
resolver
uniprot
C9JD17
resolver
uniprot
C9JUG6
resolver
uniprot_entry
GCSAM_HUMAN
resolver
uniprot_sec
C9JD17
resolver
uniprot_sec
C9JUG6
resolver
amino_acid_sequence
MGNSLLRENRRQQNTQEMPWNVRMQSPKQRTSRCWDHHIAEGCFCLPWKKILIFEKRQDSQNENERMSSTPIQDNVDQTYSEELCYTLINHRVLCTRPSGNSAEEYYENVPCKAERPRESLGGTETEYSLLHMPSTDPRHARSPEDEYELLMPHRISSHFLQQPRPLMAPSETQFSHL
uniprot
proteins
function
FUNCTION: Involved in the negative regulation of lymphocyte motility. It mediates the migration-inhibitory effects of IL6. Serves as a positive regulator of the RhoA signaling pathway. Enhancement of RhoA activation results in inhibition of lymphocyte and lymphoma cell motility by activation of its downstream effector ROCK. Is a regulator of B-cell receptor signaling, that acts through SYK kinase activation. {ECO:0000269|PubMed:17823310, ECO:0000269|PubMed:20844236, ECO:0000269|PubMed:23299888}.
uniprot
proteins
mass_dalton
21005
uniprot
proteins
mutagenesis
MUTAGEN 91; /note="H->A: Loss of FBXO10-mediated ubiquitination and degradation."; /evidence="ECO:0000269|PubMed:31570756"; MUTAGEN 106..107; /note="YY->AA: Does not affect the interaction with SYK."; /evidence="ECO:0000269|PubMed:23299888"; MUTAGEN 128; /note="Y->F: Does not affect IL6 induced phosphorylation. Does not affect the interaction with SYK."; /evidence="ECO:0000269|PubMed:17823310, ECO:0000269|PubMed:23299888"; MUTAGEN 148; /note="Y->F: Prevents IL6 induced phosphorylation. Does not affect the interaction with SYK."; /evidence="ECO:0000269|PubMed:17823310, ECO:0000269|PubMed:23299888
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on tyrosine residues can be induced by IL6. Phosphorylation is mediated by LYN. {ECO:0000269|PubMed:17823310}.; PTM: Targeted by the ubiquitin E3 ligase subunit FBXO10 to mediate its ubiquitination and degradation. {ECO:0000269|PubMed:31570756}.
uniprot
proteins
pubmed
12509382
uniprot
proteins
pubmed
12819018
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15677569
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17823310
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20844236
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23299888
uniprot
proteins
pubmed
31570756
uniprot
proteins
sequence_length
178
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cell membrane {ECO:0000269|PubMed:31570756}. Note=It relocalizes from the cytoplasm to podosome-like structures upon cell treatment with IL6.
uniprot
proteins