DTX3
entrez
196403
canonical
uniprot
Q8N9I9
canonical
ensembl
ENSG00000178498
resolver
ensp
ENSP00000338050
resolver
ensp
ENSP00000447873
resolver
ensp
ENSP00000448696
resolver
ensp
ENSP00000449294
resolver
ensp
ENSP00000554346
resolver
ensp
ENSP00000554347
resolver
ensp
ENSP00000554350
resolver
ensp
ENSP00000609657
resolver
genesymbol
DTX3
resolver
genesymbol_syn
RNF154
resolver
hgnc
HGNC:24457
resolver
uniprot
A0A346B4X6
resolver
uniprot
Q53ZZ2
resolver
uniprot
Q8NAU6
resolver
uniprot
Q8NDS8
resolver
uniprot_entry
DTX3_HUMAN
resolver
uniprot_sec
A0A346B4X6
resolver
uniprot_sec
Q53ZZ2
resolver
uniprot_sec
Q8NAU6
resolver
uniprot_sec
Q8NDS8
resolver
amino_acid_sequence
MSFVLSRMAACGGTCKNKVTVSKPVWDFLSKETPARLARLREEHRVSILIDGETSDIYVLQLSPQGPPPAPPNGLYLARKALKGLLKEAEKELKKAQRQGELMGCLALGGGGEHPEMHRAGPPPLRAAPLLPPGARGLPPPPPPLPPPLPPRLREEAEEQESTCPICLGEIQNAKTLEKCRHSFCEGCITRALQVKKACPMCGRFYGQLVGNQPQNGRMLVSKDATLLLPSYEKYGTIVIQYVFPPGVQGAEHPNPGVRYPGTTRVAYLPDCPEGNKVLTLFRKAFDQRLTFTIGTSMTTGRPNVITWNDIHHKTSCTGGPQLFGYPDPTYLTRVQEELRAKGITDD
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Functions as an ubiquitin ligase protein, and regulates Notch signaling (PubMed:35782979, PubMed:40127622). By promoting the ubiquitination and subsequent degradation of target proteins, it can block activation of the Notch signaling pathway, potentially acting as a tumor suppressor in human cancers (PubMed:31854042, PubMed:35782979, PubMed:40127622). {ECO:0000269|PubMed:31854042, ECO:0000269|PubMed:35782979, ECO:0000269|PubMed:40127622}.; FUNCTION: [Isoform 3]: Involved in the angiogenic EPHB4 kinase degradation in cancer cell. {ECO:0000269|PubMed:37108544}.
uniprot
proteins
mass_dalton
37988
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
Deltex family
uniprot
proteins
pubmed
12670957
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
31854042
uniprot
proteins
pubmed
35782979
uniprot
proteins
pubmed
37108544
uniprot
proteins
pubmed
40127622
uniprot
proteins
sequence_length
347
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:31854042}. Nucleus {ECO:0000269|PubMed:31854042}.
uniprot
proteins