P29598
uniprot
P29598
canonical
activity_regulation
ACTIVITY REGULATION: Inhibited by SERPINA5 (By similarity). Inhibited by SERPINE1 (By similarity). {ECO:0000250|UniProtKB:P00749}.
uniprot
proteins
amino_acid_sequence
MRVWLASLFLCALVANSEGGSELEASDESNCGCQNGGVCVSYKYFSSIRRCSCPKKFKGEHCEIDTSKTCYHGNGQSYRGKANTDTKGRPCLAWNSPAVLQQTYNAHRSDALSLGLGKHNYCRNPDNQRRPWCYVQIGLKQFVQECMVQDCSLSKKPSSTVDQQGFQCGQKALRPRFKIVGGEFTVVENQPWFAAIYLKNKGGSPPSFKCGGSLISPCWVASATHCFVNQPKKEEYVVYLGQSKRNSYNPGEMKFEVEQLILHEDFSDETLAFHNDIALLKIRTSTGQCAQPSRTIQTICLPPRFGDAPFGSDCEITGFGQESATDYFYPKDLKMSVVKIISHEQCKQPHYYGSEINYKMLCAADPEWKTDSCSGDSGGPLICNIDGRPTLSGIVSWGSGCAEKNKPGVYTRVSYFLNWIQSHIGEENGLAF
uniprot
proteins
ec_number
3.4.21.73
uniprot
proteins
function
FUNCTION: Serine protease that cleaves the inactive precursor plasminogen at a specific Arg-Val peptide bond, converting it into active plasmin. Secreted as an inactive zymogen, it is recruited and activated at the cell surface through interaction with the urokinase plasminogen activator receptor (uPAR). Cell-surface activation enables localized, plasmin-dependent pericellular proteolysis, regulating extracellular matrix degradation in cell migration and tissue remodeling (By similarity). Also contributes to fibrinolysis and blood clot clearance by promoting plasmin generation (By similarity). {ECO:0000250|UniProtKB:P00749, ECO:0000250|UniProtKB:P06869}.
uniprot
proteins
mass_dalton
47957
uniprot
proteins
post_translational_modification
PTM: Produced as an inactive single-chain protein (pro-uPA or sc-uPA), is processed into the active disulfide-linked two-chain form of PLAU/uPA by a proteolytic event mediated, at least, by TMPRSS4. {ECO:0000250|UniProtKB:P00749}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
1321734
uniprot
proteins
pubmed
1568219
uniprot
proteins
sequence_length
432
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P00749}. Note=Secreted as an inactive zymogen, it is activated through specific proteolytic cleavage. {ECO:0000250|UniProtKB:P00749}.
uniprot
proteins