Pard3
entrez
93742
canonical
uniprot
Q99NH2
canonical
ensembl
ENSMUSG00000025812
resolver
ensp
ENSMUSP00000026921
resolver
ensp
ENSMUSP00000078710
resolver
ensp
ENSMUSP00000124162
resolver
ensp
ENSMUSP00000124282
resolver
ensp
ENSMUSP00000124319
resolver
ensp
ENSMUSP00000124718
resolver
ensp
ENSMUSP00000125453
resolver
ensp
ENSMUSP00000125612
resolver
ensp
ENSMUSP00000267050
resolver
ensp
ENSMUSP00000267051
resolver
ensp
ENSMUSP00000267054
resolver
ensp
ENSMUSP00000267056
resolver
ensp
ENSMUSP00000267059
resolver
ensp
ENSMUSP00000267060
resolver
ensp
ENSMUSP00000267061
resolver
ensp
ENSMUSP00000267062
resolver
ensp
ENSMUSP00000267063
resolver
enst
ENSMUST00000026921
resolver
enst
ENSMUST00000079777
resolver
enst
ENSMUST00000160272
resolver
enst
ENSMUST00000162309
resolver
enst
ENSMUST00000162456
resolver
enst
ENSMUST00000162907
resolver
genesymbol
Pard3
resolver
genesymbol_syn
Par3
resolver
uniprot
A0A0R4J1Y4
resolver
uniprot
A5D6P2
resolver
uniprot
B2RUK1
resolver
uniprot
B7ZNY3
resolver
uniprot
E9PYJ2
resolver
uniprot
F7C142
resolver
uniprot
F7C7I5
resolver
uniprot
G3XA13
resolver
uniprot
Q58T10
resolver
uniprot
Q58T11
resolver
uniprot
Q8CB21
resolver
uniprot_entry
A0A0R4J1Y4_MOUSE
resolver
uniprot_entry
A5D6P2_MOUSE
resolver
uniprot_entry
B2RUK1_MOUSE
resolver
uniprot_entry
B7ZNY3_MOUSE
resolver
uniprot_entry
E9PYJ2_MOUSE
resolver
uniprot_entry
F7C142_MOUSE
resolver
uniprot_entry
F7C7I5_MOUSE
resolver
uniprot_entry
G3XA13_MOUSE
resolver
uniprot_entry
PARD3_MOUSE
resolver
uniprot_sec
Q58T10
resolver
uniprot_sec
Q58T11
resolver
uniprot_sec
Q8CB21
resolver
amino_acid_sequence
MKVTVCFGRTRVVVPCGDGRMKVFSLIQQAVTRYRKAVAKDPNYWIQVHRLEHGDGGILDLDDILCDVADDKDRLVAVFDEQDPHHGGDGTSASFTGTQSPEIFGSELGTNNVSAFQPYQATSEIEVTPSVLRANMPLHVRRSSDPALTGLSTSVSDNNFSSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKKDENYRSLPRDPSSWSNQFQRDNARSSLSASHPMVDRWLEKQEQDEEGTEEDSSRVEPVGHADTGLENMPNFSLDDMVKLVQVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEQENLFHENDCIVRINDGDLRNRRFEQAQHMFRQAMRARVIWFHVVPAANKEQYEQLSQREKNNYSPGRFSPDSHCVANRSVANNAPQALPRAPRLSQPPEQLDAHPRLPHSAHASTKPPAAPALAPPSVLSTNVGSVYNTKKVGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLAGKSQEEVVSLLRSTKMEGTVSLLVFRQEEAFHPREMNAEPSQMQTPKETKAEDEDVVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKANQEAMETLRRSMSTEGNKRGMIQLIVARRISRCNELRSPGSPAAPELPIETELDDRERRISHSLYSGIEGLDESPTRNAALSRIMGKCQLSPTVNMPHDDTVMIEDDRLPVLPPHLSDQSSSSSHDDVGFIMTEAGTWAKATISDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSDASQLDFVKTRKSKSMDLVADETKLNTVDDQRAGSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGNIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPMVDDDDEGMETLEEDTEESSRSGRESVSTSSDQPSYSLERQMNGDPEKRDKTERKKDKAGKDKKKDREKEKDKLKAKKGMLKGLGDMFRFGKHRKDDKMEKMGRIKIQDSFTSEEDRVRMKEEQERIQAKTREFRERQARERDYAEIQDFHRTFGCDDELLYGGMSSYEGCLALNARPQSPREGHLMDTLYAQVKKPRSSKPGDSNRSTPSNHDRIQRLRQEFQQAKQDEDVEDRRRTYSFEQSWSSSRPASQSGRHSVSVEVQVQRQRQEERESFQQAQRQYSSLPRQSRKNASSISQDSWEQNYAPGEGFQSAKENPRYSSYQGSRNGYLGGHGFNARVMLETQELLRQEQRRKEQQLKKQPPADGVRGPFRQDVPPSPSQVARLNRLQTPEKGRPFYS
uniprot
proteins
function
FUNCTION: Adapter protein involved in asymmetrical cell division and cell polarization processes (By similarity). Seems to play a central role in the formation of epithelial tight junctions (By similarity). Targets the phosphatase PTEN to cell junctions (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (PubMed:11839275). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (By similarity). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (By similarity). Involved in Schwann cell peripheral myelination (PubMed:21949390). {ECO:0000250|UniProtKB:Q8TEW0, ECO:0000250|UniProtKB:Q9Z340, ECO:0000269|PubMed:11839275, ECO:0000269|PubMed:21949390}.
uniprot
proteins
mass_dalton
149075
uniprot
proteins
mutagenesis
MUTAGEN 824..826; /note="SMS->AMA,EME: Strongly reduces phosphorylation by PRKCZ and abolishes interaction with PKRCI."; /evidence="ECO:0000269|PubMed:10934475"; MUTAGEN 831; /note="K->A: Inhibits Schwann cell peripheral myelination; when associated with A-848; A-881 and A-1327."; /evidence="ECO:0000269|PubMed:21949390"; MUTAGEN 848; /note="K->A: Inhibits Schwann cell peripheral myelination; when associated with A-831; A-881 and A-1327."; /evidence="ECO:0000269|PubMed:21949390"; MUTAGEN 881; /note="K->A: Inhibits Schwann cell peripheral myelination; when associated with A-831; A-848 and A-1327."; /evidence="ECO:0000269|PubMed:21949390"; MUTAGEN 1327; /note="K->A: Inhibits Schwann cell peripheral myelination; when associated with A-831; A-848 and A-881."; /evidence="ECO:0000269|PubMed:21949390
uniprot
proteins
post_translational_modification
PTM: Acetylated. Deacetylated by SIRT2, thereby inhibiting Schwann cell peripheral myelination. {ECO:0000269|PubMed:21949390}.; PTM: Phosphorylation at Ser-824 by PRKCZ and PRKCI occurs at the most apical tip of epithelial cell-cell contacts during the initial phase of tight junction formation and may promote dissociation of the complex with PARD6. EGF-induced Tyr-1123 phosphorylation mediates dissociation from LIMK2 (By similarity). Phosphorylation by AURKA at Ser-958 is required for the normal establishment of neuronal polarity (By similarity). Isoform 4 and isoform 5 are phosphorylated during oocyte maturation (Probable). {ECO:0000250, ECO:0000305}.
uniprot
proteins
protein_family
PAR3 family
uniprot
proteins
pubmed
10934474
uniprot
proteins
pubmed
10934475
uniprot
proteins
pubmed
11447115
uniprot
proteins
pubmed
11839275
uniprot
proteins
pubmed
15766746
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19893486
uniprot
proteins
pubmed
20047332
uniprot
proteins
pubmed
20080746
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21949390
uniprot
proteins
pubmed
23001562
uniprot
proteins
pubmed
9920925
uniprot
proteins
sequence_length
1333
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Endomembrane system. Cell junction. Cell junction, tight junction {ECO:0000269|PubMed:10934475, ECO:0000269|PubMed:20080746}. Cell junction, adherens junction {ECO:0000269|PubMed:20080746}. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cell membrane {ECO:0000250}. Note=Localized along the cell-cell contact region. Colocalizes with PARD6A and PRKCI at epithelial tight junctions. Colocalizes with the cortical actin that overlays the meiotic spindle during metaphase I and metaphase II. Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction (By similarity). Colocalized with SIRT2 in internode region of myelin sheath. {ECO:0000250}.
uniprot
proteins