Bmp4
entrez
12159
canonical
uniprot
P21275
canonical
ensembl
ENSMUSG00000021835
resolver
ensp
ENSMUSP00000073720
resolver
ensp
ENSMUSP00000098242
resolver
enst
ENSMUST00000074077
resolver
enst
ENSMUST00000100676
resolver
genesymbol
Bmp4
resolver
genesymbol_syn
Bmp-4
resolver
genesymbol_syn
Dvr-4
resolver
uniprot
Q3ULR1
resolver
uniprot_entry
BMP4_MOUSE
resolver
uniprot_entry
Q3ULR1_MOUSE
resolver
amino_acid_sequence
MIPGNRMLMVVLLCQVLLGGASHASLIPETGKKKVAEIQGHAGGRRSGQSHELLRDFEATLLQMFGLRRRPQPSKSAVIPDYMRDLYRLQSGEEEEEEQSQGTGLEYPERPASRANTVRSFHHEEHLENIPGTSESSAFRFLFNLSSIPENEVISSAELRLFREQVDQGPDWEQGFHRINIYEVMKPPAEMVPGHLITRLLDTRLVHHNVTRWETFDVSPAVLRWTREKQPNYGLAIEVTHLHQTRTHQGQHVRISRSLPQGSGDWAQLRPLLVTFGHDGRGHTLTRRRAKRSPKHHPQRSRKKNKNCRRHSLYVDFSDVGWNDWIVAPPGYQAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVNSSIPKACCVPTELSAISMLYLDEYDKVVLKNYQEMVVEGCGCR
uniprot
proteins
function
FUNCTION: Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis (PubMed:10049358, PubMed:14973287, PubMed:15206957). Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction (PubMed:17301089). Initiates the canonical BMP signaling cascade by associating with type I receptor BMPR1A and type II receptor BMPR2. Once all three components are bound together in a complex at the cell surface, BMPR2 phosphorylates and activates BMPR1A. In turn, BMPR1A propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target genes. Positively regulates the expression of odontogenic development regulator MSX1 via inducing the IPO7-mediated import of SMAD1 to the nucleus (PubMed:34995814). Required for MSX1-mediated mesenchymal molar tooth bud development beyond the bud stage, via promoting Wnt signaling (PubMed:27713059, PubMed:8898217). Acts as a positive regulator of odontoblast differentiation during mesenchymal tooth germ formation, expression is repressed during the bell stage by MSX1-mediated inhibition of CTNNB1 signaling (PubMed:29148101). Able to induce its own expression in dental mesenchymal cells and also in the neighboring dental epithelial cells via an MSX1-mediated pathway (PubMed:8898217). Can also signal through non-canonical BMP pathways such as ERK/MAP kinase, PI3K/Akt or SRC cascades. For example, induces SRC phosphorylation which, in turn, activates VEGFR2, leading to an angiogenic response (By similarity). {ECO:0000250|UniProtKB:P12644, ECO:0000269|PubMed:10049358, ECO:0000269|PubMed:14973287, ECO:0000269|PubMed:15206957, ECO:0000269|PubMed:17301089, ECO:0000269|PubMed:27713059, ECO:0000269|PubMed:29148101, ECO:0000269|PubMed:34995814, ECO:0000269|PubMed:8898217}.
uniprot
proteins
mass_dalton
46497
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
10049358
uniprot
proteins
pubmed
11260715
uniprot
proteins
pubmed
14623234
uniprot
proteins
pubmed
14973287
uniprot
proteins
pubmed
15039429
uniprot
proteins
pubmed
15206957
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15671031
uniprot
proteins
pubmed
15975920
uniprot
proteins
pubmed
16604073
uniprot
proteins
pubmed
17301089
uniprot
proteins
pubmed
17472960
uniprot
proteins
pubmed
1970330
uniprot
proteins
pubmed
24028588
uniprot
proteins
pubmed
27713059
uniprot
proteins
pubmed
29148101
uniprot
proteins
pubmed
32127020
uniprot
proteins
pubmed
34995814
uniprot
proteins
pubmed
7499338
uniprot
proteins
pubmed
8358941
uniprot
proteins
pubmed
8507180
uniprot
proteins
pubmed
8898217
uniprot
proteins
sequence_length
408
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix.
uniprot
proteins