Fes
entrez
14159
canonical
uniprot
P16879
canonical
ensembl
ENSMUSG00000053158
resolver
ensp
ENSMUSP00000079733
resolver
ensp
ENSMUSP00000186480
resolver
ensp
ENSMUSP00000186481
resolver
enst
ENSMUST00000080932
resolver
genesymbol
Fes
resolver
genesymbol_syn
Fps
resolver
uniprot
Q3TD20
resolver
uniprot
Q62122
resolver
uniprot
Q8CG02
resolver
uniprot
Q8CGG9
resolver
uniprot_entry
FES_MOUSE
resolver
uniprot_entry
Q8CGG9_MOUSE
resolver
uniprot_sec
Q3TD20
resolver
uniprot_sec
Q62122
resolver
uniprot_sec
Q8CG02
resolver
activity_regulation
ACTIVITY REGULATION: Kinase activity is tightly regulated. Activated in response to signaling from a cell surface receptor. Activation probably requires binding of a substrate via the SH2 domain, plus autophosphorylation at Tyr-713. Present in an inactive form in the absence of activating stimuli. {ECO:0000269|PubMed:16731527}.
uniprot
proteins
amino_acid_sequence
MGFSSELCSPQGHGAVQQMQEAELRLLEGMRKWMAQRVKSDREYAGLLHHMSLQDSGGQSWSSGPDSPVSQSWAEITSQTENLSRVLRQHAEDLNSGPLSKLSVLIRERQHLRKTYNEQWQQLQQELTKTHSQDIEKLKTQYRTLVRDSTQARRKYQEASKDKDRDKAKDKYVRSLWKLFAHHNRYVLGVRAAQLHHHHHHRFMLPGLLQSLQDLHEEMAGILKDILQEYLEISSLVQDDVASIHRELAAAAARIQPEFEYLGFLRQYGSTPDVPPCVTFDESLLEDGEQLEPGELQLNELTLESVQHTLTSVTDELAVATKEVLSRQEMVSQLQRELQSEEQNTHPRERVQLLSKRQMLQEAIQGLQIALCSQDKLQAQQELLQSKMEQLGTGEPPAVPLLQDDRHSTSSTEQEREGGRTPTLEILKSHFSGIFRPKFSIPPPLQLVPEVQKPLYEQLWYHGAIPRAEVAELLTHSGDFLVRESQGKQEYVLSVMWDGQPRHFIIQSSDNLYRLEGDGFPSIPLLITHLLSSQQPLTKKSGVVLFRAVPKDKWVLKHEDLVLGEQIGRGNFGEVFSGRLRADNTPVAVKSCRETLPPDLKAKFLQEARILKQYNHPNIVRLIGVCTQKQPIYIVMELVQGGDFLTFLRTEGARLRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGIYAASAGLRQVPVKWTAPEALNYGRYSSESDVWSFGILLWETFSLGASPYPNLTNQQTREFVEKGHRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSIICQELHSIRKRHR
uniprot
proteins
ec_number
2.7.10.2
uniprot
proteins
function
FUNCTION: Tyrosine-protein kinase that acts downstream of cell surface receptors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, cell attachment and cell spreading. Plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Acts down-stream of the activated FCER1 receptor and the mast/stem cell growth factor receptor KIT. Plays a role in the regulation of mast cell degranulation. Plays a role in the regulation of cell differentiation and promotes neurite outgrowth in response to NGF signaling. Plays a role in cell scattering and cell migration in response to HGF-induced activation of EZR. Phosphorylates BCR and down-regulates BCR kinase activity. Phosphorylates HCLS1/HS1, PECAM1, STAT3 and TRIM28. {ECO:0000269|PubMed:16731527, ECO:0000269|PubMed:17595334, ECO:0000269|PubMed:19892014}.
uniprot
proteins
mass_dalton
93779
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated on Tyr-713 in response to FGF2. Phosphorylated by LYN in response to FCER1 activation. Phosphorylated by HCK (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Fes/fps subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
11909942
uniprot
proteins
pubmed
12901971
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16731527
uniprot
proteins
pubmed
17595334
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
19892014
uniprot
proteins
pubmed
2482828
uniprot
proteins
pubmed
28463229
uniprot
proteins
pubmed
3060793
uniprot
proteins
sequence_length
822
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Golgi apparatus {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Note=Distributed throughout the cytosol when the kinase is not activated. Association with microtubules requires activation of the kinase activity. Shuttles between focal adhesions and cell-cell contacts in epithelial cells. Recruited to the lateral cell membrane in polarized epithelial cells by interaction with phosphorylated EZR. Detected at tubular membrane structures in the cytoplasm and at the cell periphery (By similarity). {ECO:0000250}.
uniprot
proteins