Q6DN03
uniprot
Q6DN03
canonical
amino_acid_sequence
MPEPAKFAPAPKKGSKKAVTKAQKKDGKKRKRSRKESYSIYVYKVLKRVHPDTGIWCKAMGIMNSFLNDIFERIAGEASRLAHYNKRSTITSRRSRRPCACCCPASWPSTPCPRAPRRSPSTPAPSESLPGPGARSLPPSLPPRVAGCFVSKGSFQGHLTTSVKESFLCCQSQLMFLASRLVNFRRAHNTKHR
uniprot
proteins
function
FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
uniprot
proteins
mass_dalton
21472
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-37 (H2BS36ph) by AMPK in response to stress promotes transcription (By similarity). Phosphorylated on Ser-15 (H2BS14ph) by STK4/MST1 during apoptosis; which facilitates apoptotic chromatin condensation. Also phosphorylated on Ser-15 in response to DNA double strand breaks (DSBs), and in correlation with somatic hypermutation and immunoglobulin class-switch recombination. {ECO:0000250|UniProtKB:Q64475, ECO:0000269|PubMed:12757711}.; PTM: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. {ECO:0000269|PubMed:21925322}.; PTM: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. {ECO:0000250|UniProtKB:P33778}.
uniprot
proteins
protein_family
Histone H2B family
uniprot
proteins
pubmed
12408966
uniprot
proteins
pubmed
12757711
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15527963
uniprot
proteins
pubmed
16283522
uniprot
proteins
pubmed
21925322
uniprot
proteins
pubmed
22389435
uniprot
proteins
pubmed
24681537
uniprot
proteins
pubmed
27105113
uniprot
proteins
pubmed
27105115
uniprot
proteins
pubmed
30154464
uniprot
proteins
pubmed
31542297
uniprot
proteins
pubmed
34545082
uniprot
proteins
pubmed
34961760
uniprot
proteins
sequence_length
193
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Chromosome.
uniprot
proteins