Oaz1
entrez
25502
canonical
uniprot
P54370
canonical
ensembl
ENSRNOG00000019459
resolver
ensp
ENSRNOP00000090905
resolver
genesymbol
Oaz1
resolver
genesymbol_syn
Oaz
resolver
uniprot_entry
OAZ1_RAT
resolver
amino_acid_sequence
MVKSSLQRILNSHCFAREKEGDKRSATLHASRTMPLLSQHSRGGCSSESSRVALHCCSNLGPGPRWCSDVPHPPLKIPGGRGNSQRDHSLSASILYSDERLNVTEEPTSNDKTRVLSIQCTLTEAKQVTWRAVWNGGGLYIELPAGPLPEGSKDSFAALLEFAEEQLRADHVFICFPKNREDRAALLRTFSFLGFEIVRPGHPLVPKRPDACFMVYTLEREDPGEED
uniprot
proteins
function
FUNCTION: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC. Stabilizes AZIN2 by interfering with its ubiquitination (By similarity). Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter (PubMed:8166639). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (By similarity). {ECO:0000250|UniProtKB:P54368, ECO:0000269|PubMed:8166639}.
uniprot
proteins
mass_dalton
25228
uniprot
proteins
protein_family
ODC antizyme family
uniprot
proteins
pubmed
16128579
uniprot
proteins
pubmed
7813017
uniprot
proteins
pubmed
8166639
uniprot
proteins
sequence_length
227
uniprot
proteins