Meiob
entrez
75178
canonical
uniprot
Q9D513
canonical
ensembl
ENSMUSG00000024155
resolver
ensp
ENSMUSP00000024972
resolver
ensp
ENSMUSP00000349076
resolver
enst
ENSMUST00000024972
resolver
genesymbol
Meiob
resolver
uniprot
E9QLG1
resolver
uniprot_entry
MEIOB_MOUSE
resolver
uniprot_sec
E9QLG1
resolver
amino_acid_sequence
MAKFFALKNFTALSDLHPNMANLKIIGIVIGKTDVKGFPDRKNIGSERYTFSFTIRDSPCHFVNVSSWGSEDYIRSLSESFRVAECVIIENPLIQRKDTEREEKFSPATPSNYKLLLSENHSMVKVCSPYEVDTKLLSLIHLPVKESRDYYSLADIVANGHSLDGRIINVLAAVRSVGEPKYFTTSDRRKGQRCEVKLFDETEPSFTMTCWDNESILLAQSWMARETVIFASDVRINFNKFQNCMAATVISKTIITVNPDTPEANILLNYIRENKETNVADEIDSYLKESVNLNTIVDVYTVEQLKVKALKSEGKADPFYGILYAYISTLNIDDETTKVVRNRCSSCGYIVNEASNTCTICNQDSSRLKSFFLSFDVLVDLTDHTGTLHSCSLSGSIAEETLGCTINEFLTMTSEQKTKLKWQLLLERSKIYLKLILSHRARGGLKVTILSCKLADPTEASRNLARQGHT
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: Single-stranded DNA-binding protein required for homologous recombination in meiosis I. Required for double strand breaks (DSBs) repair and crossover formation and promotion of faithful and complete synapsis. Not required for the initial loading of recombinases but required to maintain a proper number of RAD51 and DMC1 foci after the zygotene stage. May act by ensuring the stabilization of recombinases, which is required for successful homology search and meiotic recombination. Displays Single-stranded DNA 3'-5' exonuclease activity in vitro. {ECO:0000269|PubMed:20339383, ECO:0000269|PubMed:24068956, ECO:0000269|PubMed:24240703, ECO:0000269|PubMed:33166385}.
uniprot
proteins
mass_dalton
52975
uniprot
proteins
mutagenesis
MUTAGEN 64; /note="N->I: Decreased protein stability and half-life. Self-association observed. Impaired meiotic crossover formation with apoptosis of metaphase I spermatocytes. This mutation corresponds to the pathological variant 'I-64' identified in humans."; /evidence="ECO:0000269|PubMed:33166385"; MUTAGEN 67; /note="Missing: Strongly decreased protein stability and half-life. Self-association observed. Impaired meiotic recombination, leading to meiotic arrest, germ cell apoptosis and infertility."; /evidence="ECO:0000269|PubMed:33166385"; MUTAGEN 235; /note="R->A: Impaired DNA-binding and exonuclease activities."; /evidence="ECO:0000269|PubMed:24240703"; MUTAGEN 251; /note="S->A: Impaired exonuclease activity without affecting much the DNA-binding activity."; /evidence="ECO:0000269|PubMed:24240703
uniprot
proteins
protein_family
MEIOB family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20339383
uniprot
proteins
pubmed
24068956
uniprot
proteins
pubmed
24240703
uniprot
proteins
pubmed
32345962
uniprot
proteins
pubmed
33166385
uniprot
proteins
sequence_length
470
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20339383}. Nucleus {ECO:0000269|PubMed:24068956, ECO:0000269|PubMed:24240703}. Chromosome {ECO:0000269|PubMed:24068956, ECO:0000269|PubMed:24240703, ECO:0000269|PubMed:33166385}. Note=Co-localizes with the RPA complex on meiotic chromosome axes. Accumulates on resected DNA. Localization is dependent on SPATA22. {ECO:0000269|PubMed:24068956, ECO:0000269|PubMed:24240703}.
uniprot
proteins