Sidt2
entrez
214597
canonical
uniprot
Q8CIF6
canonical
ensembl
ENSMUSG00000034908
resolver
ensp
ENSMUSP00000044290
resolver
ensp
ENSMUSP00000110220
resolver
ensp
ENSMUSP00000246927
resolver
ensp
ENSMUSP00000246929
resolver
genesymbol
Sidt2
resolver
uniprot
Q3U1L8
resolver
uniprot
Q80XD7
resolver
uniprot
Q922R2
resolver
uniprot_entry
Q3U1L8_MOUSE
resolver
uniprot_entry
SIDT2_MOUSE
resolver
uniprot_sec
Q80XD7
resolver
uniprot_sec
Q922R2
resolver
amino_acid_sequence
MIAWRLPLCVLLVASVESHLGALGPKNVSQKDAEFERTYADDVNSELVNIYTFNHTVTRNRTEGVRVSVNVLNKQKGAPLLFVVRQKEAVVSFQVPLILRGLYQRKYLYQKVERTLCQPPTKNESEIQFFYVDVSTLSPVNTTYQLRVNRVDNFVLRTGELFTFNTTAAQPQYFKYEFPDGVDSVIVKVTSKKAFPCSVISIQDVLCPVYDLDNNVAFIGMYQTMTKKAAITVQRKDFPSNSFYVVVVVKTEDQACGGSLPFYPFVEDEPVDQGHRQKTLSVLVSQAVTSEAYVGGMLFCLGIFLSFYLLTVLLACWENWRQRKKTLLLAIDRACPESGHARVLADSFPGSAPYEGYNYGSFENGSGSTDGLVESAGSGDLSYSYQDRSFDAVGPRPRLDSMSSVEEDDYDTLTDIDSDKNVIRTKQYLCVADLARKDKRVLRKKYQIYFWNIATIAVFYALPVVQLVITYQTVVNVTGNQDICYYNFLCAHPLGNLSAFNNILSNLGYILLGLLFLLIILQREINHNRALLRNDLYALECGIPKHFGLFYAMGTALMMEGLLSACYHVCPNYTNFQFDTSFMYMIAGLCMLKLYQKRHPDINASAYSAYACLAIVIFFSVLGVVFGKGNTAFWIVFSVIHIISTLLLSTQLYYMGRWKLDSGIFRRILHVLYTDCIRQCSGPLYTDRMVLLVMGNIINWSLAAYGLIMRPNDFASYLLAIGICNLLLYFAFYIIMKLRSGERIKLIPLLCIVCTSVVWGFALFFFFQGLSTWQKTPAESREHNRDCILLDFFDDHDIWHFLSSIAMFGSFLVLLTLDDDLDTVQRDKIYVF
uniprot
proteins
function
FUNCTION: Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA and DNA is directly imported into lysosomes in an ATP-dependent manner, and degraded (PubMed:27046251, PubMed:27846365, PubMed:28724756). Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis (PubMed:28277980). In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA (PubMed:27846365). Binds long double-stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than 100 bp (PubMed:26067272). {ECO:0000269|PubMed:26067272, ECO:0000269|PubMed:27046251, ECO:0000269|PubMed:27846365, ECO:0000269|PubMed:28277980, ECO:0000269|PubMed:28724756}.
uniprot
proteins
mass_dalton
94501
uniprot
proteins
mutagenesis
MUTAGEN 154; /note="F->T: Decreased gymnosis and decreased affinity for 700-bp RNA. No effect on subcellular location."; /evidence="ECO:0000269|PubMed:26067272, ECO:0000269|PubMed:28277980"; MUTAGEN 359; /note="Y->S: Decreased lysosomal localization. Decreased interaction with AP-1 and AP-2 complexes; when associated with S-410. Almost complete loss of lysosomal localization and decreased interaction with AP-1 and AP-2 complexes; when associated with S-428. Decreased interaction with AP-1 and AP-2 complexes, almost complete loss of lysosomal localization, mislocalization to the Golgi apparatus and almost complete loss of RNA degradation by lysosomes; when associated with S-410 and S-428."; /evidence="ECO:0000269|PubMed:28724756"; MUTAGEN 410; /note="Y->S: Drastically decreased lysosomal localization. Decreased interaction with AP-1 and AP-2 complexes; when associated with S-359. Decreased interaction with AP-1 and AP-2 complexes, almost complete loss of lysosomal localization, mislocalization to the Golgi apparatus and almost complete loss of RNA degradation by lysosomes; when associated with S-359 and S-428. No effect on interaction with AP-1 and AP-2 complexes, nor on RNA uptake by lysosomes; when associated with S-428."; /evidence="ECO:0000269|PubMed:28724756"; MUTAGEN 428; /note="Y->S: Drastically decreased lysosomal localization. Almost complete loss of lysosomal localization and decreased interaction with AP-1 and AP-2 complexes; when associated with S-359. No effect on interaction with AP-1 and AP-2 complexes, nor on RNA uptake by lysosomes; when associated with S-410. Decreased interaction with AP-1 and AP-2 complexes, almost complete loss of lysosomal localization, mislocalization to the Golgi apparatus and almost complete loss of RNA degradation by lysosomes; when associated with S-359 and S-410."; /evidence="ECO:0000269|PubMed:28724756"; MUTAGEN 564; /note="S->A: Decreased gymnosis and RNA and DNA uptake by lysosomes and degradation. Decreased affinity for 700-bp RNA. No effect on lysosomal subcellular location, nor on LAMP2-binding."; /evidence="ECO:0000269|PubMed:26067272, ECO:0000269|PubMed:27046251, ECO:0000269|PubMed:28277980"; MUTAGEN 830; /note="Y->S: No effect on lysosomal localization, nor on RNA uptake by lysosomes."; /evidence="ECO:0000269|PubMed:28724756
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:20965152}.
uniprot
proteins
protein_family
SID1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
20965152
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23776622
uniprot
proteins
pubmed
26067272
uniprot
proteins
pubmed
27046251
uniprot
proteins
pubmed
27233614
uniprot
proteins
pubmed
27846365
uniprot
proteins
pubmed
27987306
uniprot
proteins
pubmed
28277980
uniprot
proteins
pubmed
28724756
uniprot
proteins
sequence_length
832
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:20965152, ECO:0000269|PubMed:27046251, ECO:0000269|PubMed:28724756}; Multi-pass membrane protein {ECO:0000269|PubMed:20965152}. Cell membrane {ECO:0000250|UniProtKB:Q8NBJ9}. Note=Mainly localizes to lysosomes and only partly to the plasma membrane (By similarity). Lysosomal localization is required for SIDT2-mediated intracellular degradation of endogenous RNA (PubMed:28724756). {ECO:0000250|UniProtKB:Q8NBJ9, ECO:0000269|PubMed:28724756}.
uniprot
proteins
transmembrane_region
TRANSMEM 294..314; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 448..468; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 500..520; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 547..567; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 606..626; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 632..652; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 689..709; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 716..736; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 747..767; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 797..817; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins