Anapc15
entrez
75430
canonical
uniprot
P60007
canonical
ensembl
ENSMUSG00000030649
resolver
ensp
ENSMUSP00000040286
resolver
ensp
ENSMUSP00000095839
resolver
ensp
ENSMUSP00000102586
resolver
ensp
ENSMUSP00000102591
resolver
ensp
ENSMUSP00000114771
resolver
ensp
ENSMUSP00000136164
resolver
ensp
ENSMUSP00000147669
resolver
ensp
ENSMUSP00000242795
resolver
ensp
ENSMUSP00000242797
resolver
ensp
ENSMUSP00000242798
resolver
ensp
ENSMUSP00000242799
resolver
ensp
ENSMUSP00000242801
resolver
ensp
ENSMUSP00000242802
resolver
ensp
ENSMUSP00000242803
resolver
ensp
ENSMUSP00000242805
resolver
ensp
ENSMUSP00000242815
resolver
ensp
ENSMUSP00000350220
resolver
enst
ENSMUST00000035395
resolver
enst
ENSMUST00000098237
resolver
enst
ENSMUST00000106973
resolver
genesymbol
Anapc15
resolver
genesymbol_syn
3200002M19Rik
resolver
uniprot
G5E8M3
resolver
uniprot
H3BIU1
resolver
uniprot
Q3UT90
resolver
uniprot
Q3UXV5
resolver
uniprot
Q9CXK2
resolver
uniprot
Q9D3A0
resolver
uniprot
Q9Y269
resolver
uniprot_entry
APC15_MOUSE
resolver
uniprot_entry
G5E8M3_MOUSE
resolver
uniprot_entry
H3BIU1_MOUSE
resolver
uniprot_entry
Q9D3A0_MOUSE
resolver
uniprot_sec
Q3UT90
resolver
uniprot_sec
Q3UXV5
resolver
uniprot_sec
Q9CXK2
resolver
uniprot_sec
Q9Y269
resolver
amino_acid_sequence
MEPGLKLSLGAMSTLFPSLFPRVTETLWFNLDRPCVEETELQQQEQQHQAWLQSIAEKDNNLVPIGKPASEHYDDEEEEDDEDDEDSEEDSEDDEDMQDMDEMNDYNESPDDGEVNEVDMEGNEQDQDQWMI
uniprot
proteins
function
FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (By similarity). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (By similarity). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (By similarity). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (By similarity). Also required for degradation of CDC20 (By similarity). {ECO:0000250|UniProtKB:P60006}.
uniprot
proteins
mass_dalton
15378
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:P60006}.
uniprot
proteins
protein_family
APC15 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
132
uniprot
proteins