Svip
entrez
75744
canonical
uniprot
Q3UZP4
canonical
ensembl
ENSMUSG00000074093
resolver
ensp
ENSMUSP00000096014
resolver
enst
ENSMUST00000098414
resolver
genesymbol
Svip
resolver
uniprot
Q3TYK1
resolver
uniprot_entry
Q3TYK1_MOUSE
resolver
uniprot_entry
SVIP_MOUSE
resolver
amino_acid_sequence
MGLCFPCPAESAPPSPSPEEKREKLAEAAERRQKEAATRGILDIQSVEAKKKKKEQLEKQMATSGPPTAGGLRWTVS
uniprot
proteins
function
FUNCTION: Negative regulator of the ER-associated degradation pathway (ERAD) of misfolded proteins. It competes with AMFR/gp78 for binding VCP/p97, and inhibits AMFR/gp78-VCP/p97 complex formation that is required for degradation of ERAD substrates. Involved in the regulation of adrenal cortisol and dehydroepiandrosterone (DHEA) biosynthesis. {ECO:0000250|UniProtKB:Q8NHG7}.
uniprot
proteins
mass_dalton
8364
uniprot
proteins
protein_family
SVIP family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
35042898
uniprot
proteins
sequence_length
77
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q8NHG7}; Lipid-anchor {ECO:0000250|UniProtKB:Q8NHG7}. Smooth endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P0C0A9}; Peripheral membrane protein {ECO:0000250|UniProtKB:P0C0A9}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P0C0A9}; Peripheral membrane protein {ECO:0000250|UniProtKB:P0C0A9}. Cell membrane {ECO:0000250|UniProtKB:P0C0A9}; Peripheral membrane protein {ECO:0000250|UniProtKB:P0C0A9}. Lysosome membrane {ECO:0000250|UniProtKB:Q8NHG7}.
uniprot
proteins