Smo
entrez
25273
canonical
uniprot
P97698
canonical
ensembl
ENSRNOG00000008332
resolver
ensembl
ENSRNOG00055022580
resolver
ensembl
ENSRNOG00060027470
resolver
ensembl
ENSRNOG00065025908
resolver
ensp
ENSRNOP00000070665
resolver
ensp
ENSRNOP00055031455
resolver
ensp
ENSRNOP00060039636
resolver
ensp
ENSRNOP00065036579
resolver
enst
ENSRNOT00000080223
resolver
enst
ENSRNOT00055038745
resolver
enst
ENSRNOT00060047647
resolver
enst
ENSRNOT00065044664
resolver
genesymbol
Smo
resolver
uniprot
A0A0G2JYI3
resolver
uniprot
G3V736
resolver
uniprot_entry
A0A0G2JYI3_RAT
resolver
uniprot_entry
SMO_RAT
resolver
uniprot_sec
G3V736
resolver
amino_acid_sequence
MAAGRPVRGPELAPRRLLQLLLLVLLGGRGRGAALSGNVTGPGPRSAGGSARRNAPVTSPPPPLLSHCGRAAHCEPLRYNVCLGSALPYGATTTLLAGDSDSQEEAHSKLVLWSGLRNAPRCWAVIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDHFPEGCPNEVQNIKFNSSGQCEAPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGTMRFGEPTSSETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQANVTIGLPTKKPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLIWRRTWCRLTGHSDDEPKRIKKSKMIAKAFSKRRELLQNPGQELSFSMHTVSHDGPVAGLAFELNEPSADVSSAWAQHVTKMVARRGAILPQDVSVTPVATPVPPEEQANLWLVEAEISPELEKRLGRKKKRRKRKKEVCPLGPAPELHHSAPVPATSAVPRLPQLPRQKCLVAANAWGTGEPCRQGAWTVVSNPFCPEPSPHQDPFLPGASAPRVWAQGRLQGLGSIHSRTNLMEAELLDADSDF
uniprot
proteins
function
FUNCTION: G protein-coupled receptor, which transduces the smoothened signaling pathway. Activated by cholesterol in response to hedgehog (DHH, IHH or SHH) morphogens. In absence of hedgehog, SMO is inactivated by patched protein (PTCH1 or PTCH2), which prevents SMO access to cholesterol. In response to hedgehog-binding to pathched, inhibition is relieved, promoting SMO translocation to primary cilium and activation by cholesterol: cholesterol causes a conformation change that triggers signaling via G protein G(i), mediating inhibition of adenylate cyclase activity and decreassed production of cAMP. Decreased cAMP levels then inhibit protein kinase A (PKA) and promote release of GLI (GLI1, GLI2 and GLI3) transcription factors, which activate expression of target genes. Active SMO also directly inhibits PKA by sequestering its catalytic subunit, PRKACA, at the cell membrane, preventing PRKACA-mediated phosphorylation and subsequent processing of GLI transcription factors (By similarity). Active SMO also promotes the removal of GPR161, a key inhibitor of the smoothened signaling pathway, from primary cilia (By similarity). {ECO:0000250|UniProtKB:P56726, ECO:0000250|UniProtKB:Q99835}.
uniprot
proteins
mass_dalton
87376
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by GRK2 and/GRK3 kinases promotes interaction with protein kinase A catalytic subunit PRKACA. {ECO:0000250|UniProtKB:P56726}.
uniprot
proteins
protein_family
G protein-coupled receptor Fz/Smo family
uniprot
proteins
pubmed
8906787
uniprot
proteins
sequence_length
793
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P56726}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q99835}. Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q99835}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q99835}. Note=Translocates to primary cilium in response to hedgehog (DHH, IHH or SHH) morphogens (By similarity). Cilium localization is mediated via a beta-arrestin and KIF3A-dependent mechanism (By similarity). {ECO:0000250|UniProtKB:P56726}.
uniprot
proteins
transmembrane_region
TRANSMEM 238..258; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 267..287; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 319..339; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 363..383; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 407..427; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 456..476; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 529..549; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins