ITGA4
entrez
3676
canonical
uniprot
P13612
canonical
ensembl
ENSG00000115232
resolver
ensp
ENSP00000340149
resolver
ensp
ENSP00000380227
resolver
genesymbol
ITGA4
resolver
genesymbol_syn
CD49D
resolver
hgnc
HGNC:6140
resolver
uniprot
D3DPG4
resolver
uniprot
Q7Z4L6
resolver
uniprot_entry
ITA4_HUMAN
resolver
uniprot_sec
D3DPG4
resolver
uniprot_sec
Q7Z4L6
resolver
amino_acid_sequence
MAWEARREPGPRRAAVRETVMLLLCLGVPTGRPYNVDTESALLYQGPHNTLFGYSVVLHSHGANRWLLVGAPTANWLANASVINPGAIYRCRIGKNPGQTCEQLQLGSPNGEPCGKTCLEERDNQWLGVTLSRQPGENGSIVTCGHRWKNIFYIKNENKLPTGGCYGVPPDLRTELSKRIAPCYQDYVKKFGENFASCQAGISSFYTKDLIVMGAPGSSYWTGSLFVYNITTNKYKAFLDKQNQVKFGSYLGYSVGAGHFRSQHTTEVVGGAPQHEQIGKAYIFSIDEKELNILHEMKGKKLGSYFGASVCAVDLNADGFSDLLVGAPMQSTIREEGRVFVYINSGSGAVMNAMETNLVGSDKYAARFGESIVNLGDIDNDGFEDVAIGAPQEDDLQGAIYIYNGRADGISSTFSQRIEGLQISKSLSMFGQSISGQIDADNNGYVDVAVGAFRSDSAVLLRTRPVVIVDASLSHPESVNRTKFDCVENGWPSVCIDLTLCFSYKGKEVPGYIVLFYNMSLDVNRKAESPPRFYFSSNGTSDVITGSIQVSSREANCRTHQAFMRKDVRDILTPIQIEAAYHLGPHVISKRSTEEFPPLQPILQQKKEKDIMKKTINFARFCAHENCSADLQVSAKIGFLKPHENKTYLAVGSMKTLMLNVSLFNAGDDAYETTLHVKLPVGLYFIKILELEEKQINCEVTDNSGVVQLDCSIGYIYVDHLSRIDISFLLDVSSLSRAEEDLSITVHATCENEEEMDNLKHSRVTVAIPLKYEVKLTVHGFVNPTSFVYGSNDENEPETCMVEKMNLTFHVINTGNSMAPNVSVEIMVPNSFSPQTDKLFNILDVQTTTGECHFENYQRVCALEQQKSAMQTLKGIVRFLSKTDKRLLYCIKADPHCLNFLCNFGKMESGKEASVHIQLEGRPSILEMDETSALKFEIRATGFPEPNPRVIELNKDENVAHVLLEGLHHQRPKRYFTIVIISSSLLLGLIVLLLISYVMWKAGFFKRQYKSILQEENRRDSWSYINSKSNDD
uniprot
proteins
function
FUNCTION: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). Integrin ITGA4:ITGB1 represses PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via its interaction with SVEP1, thereby inhibiting vasocontraction (PubMed:35802072). {ECO:0000269|PubMed:18635536, ECO:0000269|PubMed:19064666, ECO:0000269|PubMed:23125415, ECO:0000269|PubMed:25398877, ECO:0000269|PubMed:35802072}.
uniprot
proteins
mass_dalton
114900
uniprot
proteins
mutagenesis
MUTAGEN 222; /note="T->A: Blocks binding to PLA2G2A."; /evidence="ECO:0000269|PubMed:18635536"; MUTAGEN 223; /note="G->A: Blocks binding to PLA2G2A."; /evidence="ECO:0000269|PubMed:18635536"; MUTAGEN 590; /note="K->Q: Abolishes almost completely cleavage."; /evidence="ECO:0000269|PubMed:1730718"; MUTAGEN 591; /note="R->L: Abolishes completely cleavage."; /evidence="ECO:0000269|PubMed:1730718"; MUTAGEN 1021; /note="S->A: Abolishes phosphorylation."; /evidence="ECO:0000269|PubMed:11533025"; MUTAGEN 1021; /note="S->D: Reduces PXN binding."; /evidence="ECO:0000269|PubMed:11533025"; MUTAGEN 1024; /note="Y->A: Disrupts PXN binding."; /evidence="ECO:0000269|PubMed:10604475
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Ser-1027 inhibits PXN binding. {ECO:0000269|PubMed:11533025}.
uniprot
proteins
protein_family
Integrin alpha chain family
uniprot
proteins
pubmed
10604475
uniprot
proteins
pubmed
11533025
uniprot
proteins
pubmed
15466886
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1551405
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17158232
uniprot
proteins
pubmed
1730718
uniprot
proteins
pubmed
18635536
uniprot
proteins
pubmed
19064666
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
2034655
uniprot
proteins
pubmed
23125415
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25398877
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
2788572
uniprot
proteins
pubmed
3033641
uniprot
proteins
pubmed
35802072
uniprot
proteins
pubmed
37184585
uniprot
proteins
pubmed
8643114
uniprot
proteins
pubmed
9488735
uniprot
proteins
sequence_length
1032
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 978..1001; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins