Prdx4
entrez
85274
canonical
uniprot
Q9Z0V5
canonical
ensembl
ENSRNOG00000003763
resolver
ensp
ENSRNOP00000005014
resolver
ensp
ENSRNOP00000080648
resolver
ensp
ENSRNOP00000086837
resolver
enst
ENSRNOT00000105854
resolver
genesymbol
Prdx4
resolver
genesymbol_syn
Rno2CysPrx04
resolver
uniprot
A0A8I6AER1
resolver
uniprot_entry
A0A8I6AER1_RAT
resolver
uniprot_entry
PRDX4_RAT
resolver
amino_acid_sequence
METWSKLLDGTTPSRRWRKLVLLLPPLLLFLLQTEALQGLESDDRFRTRENECHFYAGGQVYPGEVSRVSVADHSLHLSKAKISKPAPYWEGTAVINGEFKELKLTDYRGKYLVFFFYPLDFTFVCPTEIIAFGDRIEEFKSINTEVVACSVDSQFTHLAWINTPRRQGGLGPIRIPLLSDLNHQISKDYGVYLEDSGHTLRGLFIIDDKGVLRQITLNDLPVGRSVDETLRLVQAFQYTDKHGEVCPAGWKPGSETIIPDPAGKLKYFDKLN
uniprot
proteins
ec_number
1.11.1.24
uniprot
proteins
function
FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. {ECO:0000250|UniProtKB:Q13162}.
uniprot
proteins
mass_dalton
31007
uniprot
proteins
post_translational_modification
PTM: The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond. {ECO:0000250|UniProtKB:Q13162}.
uniprot
proteins
protein_family
AhpC/Prx1 subfamily
uniprot
proteins
protein_family
Peroxiredoxin family
uniprot
proteins
pubmed
10025941
uniprot
proteins
pubmed
10731722
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
273
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q13162}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q13162}. Secreted {ECO:0000269|PubMed:10025941, ECO:0000269|PubMed:10731722}.
uniprot
proteins