DUS2
entrez
54920
canonical
uniprot
Q9NX74
canonical
ensembl
ENSG00000167264
resolver
ensp
ENSP00000351769
resolver
ensp
ENSP00000409498
resolver
ensp
ENSP00000455229
resolver
ensp
ENSP00000529158
resolver
ensp
ENSP00000529159
resolver
ensp
ENSP00000529161
resolver
ensp
ENSP00000529164
resolver
ensp
ENSP00000529165
resolver
ensp
ENSP00000529166
resolver
ensp
ENSP00000529171
resolver
ensp
ENSP00000529172
resolver
ensp
ENSP00000529173
resolver
ensp
ENSP00000584625
resolver
ensp
ENSP00000584637
resolver
ensp
ENSP00000584638
resolver
ensp
ENSP00000584639
resolver
ensp
ENSP00000584640
resolver
ensp
ENSP00000640077
resolver
ensp
ENSP00000640079
resolver
ensp
ENSP00000640080
resolver
ensp
ENSP00000640083
resolver
ensp
ENSP00000640084
resolver
enst
ENST00000358896
resolver
enst
ENST00000432752
resolver
enst
ENST00000565263
resolver
enst
ENST00000859099
resolver
enst
ENST00000859100
resolver
enst
ENST00000859102
resolver
enst
ENST00000859105
resolver
enst
ENST00000859106
resolver
enst
ENST00000859107
resolver
enst
ENST00000859112
resolver
enst
ENST00000859113
resolver
enst
ENST00000859114
resolver
enst
ENST00000914566
resolver
enst
ENST00000914578
resolver
enst
ENST00000914579
resolver
enst
ENST00000914580
resolver
enst
ENST00000914581
resolver
enst
ENST00000970018
resolver
enst
ENST00000970020
resolver
enst
ENST00000970021
resolver
enst
ENST00000970024
resolver
enst
ENST00000970025
resolver
genesymbol
DUS2
resolver
genesymbol_syn
DUS2L
resolver
hgnc
HGNC:26014
resolver
uniprot
A8K3G3
resolver
uniprot
B4DKP8
resolver
uniprot
E7EUN9
resolver
uniprot
Q4H4D9
resolver
uniprot_entry
B4DKP8_HUMAN
resolver
uniprot_entry
DUS2_HUMAN
resolver
uniprot_entry
E7EUN9_HUMAN
resolver
uniprot_sec
A8K3G3
resolver
uniprot_sec
Q4H4D9
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by canertinib, PD 168393, AST-1306 and PF-6274484. {ECO:0000269|PubMed:38680565}.
uniprot
proteins
amino_acid_sequence
MILNSLSLCYHNKLILAPMVRVGTLPMRLLALDYGADIVYCEELIDLKMIQCKRVVNEVLSTVDFVAPDDRVVFRTCEREQNRVVFQMGTSDAERALAVARLVENDVAGIDVNMGCPKQYSTKGGMGAALLSDPDKIEKILSTLVKGTRRPVTCKIRILPSLEDTLSLVKRIERTGIAAIAVHGRKREERPQHPVSCEVIKAIADTLSIPVIANGGSHDHIQQYSDIEDFRQATAASSVMVARAAMWNPSIFLKEGLRPLEEVMQKYIRYAVQYDNHYTNTKYCLCQMLREQLESPQGRLLHAAQSSREICEAFGLGAFYEETTQELDAQQARLSAKTSEQTGEPAEDTSGVIKMAVKFDRRAYPAQITPKMCLLEWCRREKLAQPVYETVQRPLDRLFSSIVTVAEQKYQSTLWDKSKKLAEQAAAIVCLRSQGLPEGRLGEESPSLHKRKREAPDQDPGGPRAQELAQPGDLCKKPFVALGSGEESPLEGW
uniprot
proteins
ec_number
1.3.1.91
uniprot
proteins
function
FUNCTION: Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (PubMed:15994936, PubMed:26429968, PubMed:30149704, PubMed:34798057, PubMed:38680565). Specifically modifies U20 in cytoplasmic tRNAs (PubMed:38680565). Activity depends on the presence of guanosine at position 19 in the tRNA substrate (PubMed:38680565). Negatively regulates the activation of EIF2AK2/PKR (PubMed:18096616). {ECO:0000269|PubMed:15994936, ECO:0000269|PubMed:18096616, ECO:0000269|PubMed:26429968, ECO:0000269|PubMed:30149704, ECO:0000269|PubMed:34798057, ECO:0000269|PubMed:38680565}.
uniprot
proteins
mass_dalton
55050
uniprot
proteins
mutagenesis
MUTAGEN 294; /note="E->K: Increased affinity for tRNA and increased dihydrouridine synthesis; when associated with K-305."; /evidence="ECO:0000269|PubMed:30149704"; MUTAGEN 305; /note="Q->K: Increased affinity for tRNA and increased dihydrouridine synthesis; when associated with K-294."; /evidence="ECO:0000269|PubMed:30149704"; MUTAGEN 361..362; /note="RR->AA: Decreased affinity for tRNA."; /evidence="ECO:0000269|PubMed:30605527"; MUTAGEN 367; /note="Q->A: Mildly decreased affinity for tRNA."; /evidence="ECO:0000269|PubMed:30605527"; MUTAGEN 371; /note="K->A: Strongly decreased affinity for tRNA."; /evidence="ECO:0000269|PubMed:30605527"; MUTAGEN 372; /note="M->A: Mildly decreased affinity for tRNA."; /evidence="ECO:0000269|PubMed:30605527"; MUTAGEN 379; /note="R->A: Mildly decreased affinity for tRNA."; /evidence="ECO:0000269|PubMed:30605527"; MUTAGEN 397; /note="R->A: Mildly decreased affinity for tRNA."; /evidence="ECO:0000269|PubMed:30605527"; MUTAGEN 417; /note="K->A: Mildly decreased affinity for tRNA."; /evidence="ECO:0000269|PubMed:30605527"; MUTAGEN 419; /note="K->A: Decreased affinity for tRNA. Strongly decreased affinity for tRNA; when associated with A-420."; /evidence="ECO:0000269|PubMed:30605527"; MUTAGEN 420; /note="K->A: Decreased affinity for tRNA. Strongly decreased affinity for tRNA; when associated with A-419."; /evidence="ECO:0000269|PubMed:30605527
uniprot
proteins
protein_family
Dus family
uniprot
proteins
protein_family
Dus2 subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
15994936
uniprot
proteins
pubmed
18096616
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26143927
uniprot
proteins
pubmed
26429968
uniprot
proteins
pubmed
30149704
uniprot
proteins
pubmed
30605527
uniprot
proteins
pubmed
34798057
uniprot
proteins
pubmed
38680565
uniprot
proteins
sequence_length
493
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15994936}. Endoplasmic reticulum {ECO:0000269|PubMed:15994936}. Note=Mainly at the endoplasmic reticulum. {ECO:0000269|PubMed:15994936}.
uniprot
proteins