Ccnf
entrez
12449
canonical
uniprot
P51944
canonical
ensembl
ENSMUSG00000072082
resolver
ensp
ENSMUSP00000111048
resolver
ensp
ENSMUSP00000321447
resolver
ensp
ENSMUSP00000321449
resolver
ensp
ENSMUSP00000321453
resolver
ensp
ENSMUSP00000335395
resolver
genesymbol
Ccnf
resolver
uniprot
Q3TF73
resolver
uniprot
Q60797
resolver
uniprot
Q60799
resolver
uniprot
Q8BSX9
resolver
uniprot
Q8C4D9
resolver
uniprot
Q8CI26
resolver
uniprot_entry
CCNF_MOUSE
resolver
uniprot_sec
Q3TF73
resolver
uniprot_sec
Q60797
resolver
uniprot_sec
Q60799
resolver
uniprot_sec
Q8BSX9
resolver
uniprot_sec
Q8C4D9
resolver
uniprot_sec
Q8CI26
resolver
amino_acid_sequence
MGSGGVIHCRCAKCFCYPTKRRIKRRPRNLTILSLPEDVLFHILKWLSVGDILAVRAVHSHLKYLVDNHASVWASASFQELWPSPQNLKLFERAAEKGNFEAAVKLGIAYLYNEGLSVSDEACAEVNGLKASRFFSMAERLNTGSEPFIWLFIRPPWSVSGSCCKAVVHDSLRAECQLQRSHKASILHCLGRVLNLFEDEEKRKQARSLLEESSRQGCLISSYLLWESDRKVDMSDPGRCLHSFRKLRDYAAKGCWEAQLALAKACAGGSQLGLEGKACSESVCQLFQASQAVNKQQIFSVQKGLSDTMRYILIDWLVEVATMKDFTSLCLHLTVECVDRYLRRRLVPRYKLQLLGIACMVICTRFISKEILTIREAVWLTDNTYKYEDLVRVMGEIISALEGKIRIPTVVDYKEVLLTLVPVAPRTQHLCSFLCELTLLHTSLSIYAPARLASAALLLARLMHGQTQPWTTHLWDLTGFSYSDLVPCVLSLHKKCFHDDAPKDYRQVSLTAVKQRFEDKCYEEISREEVLSYADLCSTIGVKQESPEPPSFPSSGEIHTFLSSPSGRRSKRKRENSLQEDRGSFVTTPTAELSNQEETLLGSLLDWSLECCSGYEGDQESEGEKEGDVTAPSRLLDVTVVYLNPEEHCCQESSDEEAWPEDKIHPAPGTQAPPASAPRPLLCNRGDRAKDITTSGYSSVSSSSPISSLDGGMGGSPQSTSVLSVGSHSSTKPCHHQAKKSCLQCRPPNSPESGVHQQPVKRQNLSVHSDKDMHLAS
uniprot
proteins
function
FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). The SCF(CCNF) E3 ubiquitin-protein ligase complex is an integral component of the ubiquitin proteasome system (UPS) and links proteasome degradation to the cell cycle (By similarity). Mediates the substrate recognition and the proteasomal degradation of various target proteins involved in the regulation of cell cycle progression and in the maintenance of genome stability (By similarity). Mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication (By similarity). In G2, mediates the ubiquitination and proteasomal degradation of CDC6, thereby suppressing DNA re-replication and preventing genome instability (By similarity). Involved in the ubiquitination and degradation of the substrate adapter CDH1 of the anaphase-promoting complex (APC/C), thereby acting as an antagonist of APC/C in regulating G1 progression and S phase entry (By similarity). May play a role in the G2 cell cycle checkpoint control after DNA damage, possibly by promoting the ubiquitination of MYBL2/BMYB (By similarity). {ECO:0000250|UniProtKB:P41002}.
uniprot
proteins
mass_dalton
86623
uniprot
proteins
post_translational_modification
PTM: Degraded when the spindle assembly checkpoint is activated during the G2-M transition. Degradation is not dependent on the proteasome or ubiquitin and depends on the C-terminal PEST sequence. {ECO:0000250|UniProtKB:P41002}.; PTM: Phosphorylated just before cells enter into mitosis. {ECO:0000250|UniProtKB:P41002}.; PTM: Ubiquitinated by the anaphase-promoting complex (APC/C); leading to its degradation by the proteasome. {ECO:0000250|UniProtKB:P41002}.
uniprot
proteins
protein_family
Cyclin AB subfamily
uniprot
proteins
protein_family
Cyclin family
uniprot
proteins
pubmed
11572993
uniprot
proteins
pubmed
12867420
uniprot
proteins
pubmed
14993286
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
7767003
uniprot
proteins
sequence_length
777
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P41002}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P41002}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:P41002}. Note=Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localization to centrosomes is not dependent on CP110. Localizes to the nucleus in G2 phase. {ECO:0000250|UniProtKB:P41002}.
uniprot
proteins