AR
entrez
367
canonical
uniprot
P10275
canonical
ensembl
ENSG00000169083
resolver
ensp
ENSP00000363822
resolver
ensp
ENSP00000421155
resolver
ensp
ENSP00000479013
resolver
enst
ENST00000613054
resolver
genesymbol
AR
resolver
genesymbol
AR8
resolver
genesymbol
NR3C4
resolver
genesymbol_syn
DHTR
resolver
genesymbol_syn
NR3C4
resolver
hgnc
HGNC:644
resolver
uniprot
A0A087WUX9
resolver
uniprot
A0A0B4J1T2
resolver
uniprot
A2RUN2
resolver
uniprot
B1AKD7
resolver
uniprot
C0JKD3
resolver
uniprot
C0JKD4
resolver
uniprot
E7EVX6
resolver
uniprot
F1D8N5
resolver
uniprot
G4VV16
resolver
uniprot
Q9NUA2
resolver
uniprot
Q9UD95
resolver
uniprot_entry
A0A087WUX9_HUMAN
resolver
uniprot_entry
ANDR_HUMAN
resolver
uniprot_entry
F1D8N5_HUMAN
resolver
uniprot_entry
G4VV16_HUMAN
resolver
uniprot_entry
Q9NUA2_HUMAN
resolver
uniprot_sec
A0A0B4J1T2
resolver
uniprot_sec
A2RUN2
resolver
uniprot_sec
B1AKD7
resolver
uniprot_sec
C0JKD3
resolver
uniprot_sec
C0JKD4
resolver
uniprot_sec
E7EVX6
resolver
uniprot_sec
Q9UD95
resolver
activity_regulation
ACTIVITY REGULATION: AIM-100 (4-amino-5,6-biaryl-furo[2,3-d]pyrimidine) suppresses TNK2-mediated phosphorylation at Tyr-269. Inhibits the binding of the Tyr-269 phosphorylated form to androgen-responsive enhancers (AREs) and its transcriptional activity. {ECO:0000269|PubMed:20623637}.
uniprot
proteins
amino_acid_sequence
MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREVIQNPGPRHPEAASAAPPGASLLLLQQQQQQQQQQQQQQQQQQQQQQQETSPRQQQQQQGEDGSPQAHRRGPTGYLVLDEEQQPSQPQSALECHPERGCVPEPGAAVAASKGLPQQLPAPPDEDDSAAPSTLSLLGPTFPGLSSCSADLKDILSEASTMQLLQQQQQEAVSEGSSSGRAREASGAPTSSKDNYLGGTSTISDNAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYAPLLGVPPAVRPTPCAPLAECKGSLLDDSAGKSTEDTAEYSPFKGGYTKGLEGESLGCSGSAAAGSSGTLELPSTLSLYKSGALDEAAAYQSRDYYNFPLALAGPPPPPPPPHPHARIKLENPLDYGSAWAAAAAQCRYGDLASLHGAGAAGPGSGSPSAAASSSWHTLFTAEEGQLYGPCGGGGGGGGGGGGGGGGGGGGGGGEAGAVAPYGYTRPPQGLAGQESDFTAPDVWYPGGMVSRVPYPSPTCVKSEMGPWMDSYSGPYGDMRLETARDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGEASSTTSPTEETTQKLTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ
uniprot
proteins
disease_involvement
DISEASE: Androgen insensitivity syndrome (AIS) [MIM:300068]: An X-linked recessive form of pseudohermaphroditism due end-organ resistance to androgen. Affected males have female external genitalia, female breast development, blind vagina, absent uterus and female adnexa, and abdominal or inguinal testes, despite a normal 46,XY karyotype. {ECO:0000269|PubMed:10022458, ECO:0000269|PubMed:10221692, ECO:0000269|PubMed:10221770, ECO:0000269|PubMed:10359561, ECO:0000269|PubMed:10404311, ECO:0000269|PubMed:10425033, ECO:0000269|PubMed:10458483, ECO:0000269|PubMed:10571951, ECO:0000269|PubMed:10590024, ECO:0000269|PubMed:10690872, ECO:0000269|PubMed:10946887, ECO:0000269|PubMed:11587068, ECO:0000269|PubMed:11744994, ECO:0000269|PubMed:1307250, ECO:0000269|PubMed:1316540, ECO:0000269|PubMed:1426313, ECO:0000269|PubMed:1430233, ECO:0000269|PubMed:1458719, ECO:0000269|PubMed:1464650, ECO:0000269|PubMed:14756668, ECO:0000269|PubMed:1480178, ECO:0000269|PubMed:1487249, ECO:0000269|PubMed:1569163, ECO:0000269|PubMed:1609793, ECO:0000269|PubMed:16129672, ECO:0000269|PubMed:16595706, ECO:0000269|PubMed:1775137, ECO:0000269|PubMed:1999491, ECO:0000269|PubMed:2082179, ECO:0000269|PubMed:24737579, ECO:0000269|PubMed:2594783, ECO:0000269|PubMed:7537149, ECO:0000269|PubMed:7581399, ECO:0000269|PubMed:7626493, ECO:0000269|PubMed:7633398, ECO:0000269|PubMed:7641413, ECO:0000269|PubMed:7671849, ECO:0000269|PubMed:7929841, ECO:0000269|PubMed:7962294, ECO:0000269|PubMed:7970939, ECO:0000269|PubMed:7981687, ECO:0000269|PubMed:7981689, ECO:0000269|PubMed:7993455, ECO:0000269|PubMed:8040309, ECO:0000269|PubMed:8096390, ECO:0000269|PubMed:8103398, ECO:0000269|PubMed:8162033, ECO:0000269|PubMed:8224266, ECO:0000269|PubMed:8240973, ECO:0000269|PubMed:8281140, ECO:0000269|PubMed:8325950, ECO:0000269|PubMed:8339746, ECO:0000269|PubMed:8413310, ECO:0000269|PubMed:8446106, ECO:0000269|PubMed:8626869, ECO:0000269|PubMed:8647313, ECO:0000269|PubMed:8683794, ECO:0000269|PubMed:8723113, ECO:0000269|PubMed:8768864, ECO:0000269|PubMed:8809734, ECO:0000269|PubMed:8830623, ECO:0000269|PubMed:8918984, ECO:0000269|PubMed:8990010, ECO:0000269|PubMed:9001799, ECO:0000269|PubMed:9007482, ECO:0000269|PubMed:9039340, ECO:0000269|PubMed:9106550, ECO:0000269|PubMed:9160185, ECO:0000269|PubMed:9252933, ECO:0000269|PubMed:9255042, ECO:0000269|PubMed:9302173, ECO:0000269|PubMed:9328206, ECO:0000269|PubMed:9421404, ECO:0000269|PubMed:9544375, ECO:0000269|PubMed:9554754, ECO:0000269|PubMed:9610419, ECO:0000269|PubMed:9627582, ECO:0000269|PubMed:9698822, ECO:0000269|PubMed:9851768, ECO:0000269|PubMed:9856504, ECO:0000269|Ref.118, ECO:0000269|Ref.185}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Spinal and bulbar muscular atrophy X-linked 1 (SMAX1) [MIM:313200]: An X-linked recessive form of spinal muscular atrophy. Spinal muscular atrophy refers to a group of neuromuscular disorders characterized by degeneration of the anterior horn cells of the spinal cord, leading to symmetrical muscle weakness and atrophy. SMAX1 occurs only in men. Age at onset is usually in the third to fifth decade of life, but earlier involvement has been reported. It is characterized by slowly progressive limb and bulbar muscle weakness with fasciculations, muscle atrophy, and gynecomastia. The disorder is clinically similar to classic forms of autosomal spinal muscular atrophy. {ECO:0000269|PubMed:15851746}. Note=The disease is caused by variants affecting the gene represented in this entry. Caused by trinucleotide CAG repeat expansion. In SMAX1 patients the number of Gln ranges from 38 to 62. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.; DISEASE: Prostate cancer, hereditary, X-linked 3 (HPCX3) [MIM:301120]: A condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. {ECO:0000269|PubMed:8530589}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; DISEASE: Note=Defects in AR may play a role in metastatic prostate cancer. The mutated receptor stimulates prostate growth and metastases development despite of androgen ablation. This treatment can reduce primary and metastatic lesions probably by inducing apoptosis of tumor cells when they express the wild-type receptor. {ECO:0000269|PubMed:10363963, ECO:0000269|PubMed:10569618, ECO:0000269|PubMed:1562539, ECO:0000269|PubMed:16129672, ECO:0000269|PubMed:17311914, ECO:0000269|PubMed:2260966, ECO:0000269|PubMed:25091737, ECO:0000269|PubMed:8187068, ECO:0000269|PubMed:8274409, ECO:0000269|PubMed:8827083}.; DISEASE: Androgen insensitivity, partial (PAIS) [MIM:312300]: A disorder that is characterized by hypospadias, hypogonadism, gynecomastia, genital ambiguity, normal XY karyotype, and a pedigree pattern consistent with X-linked recessive inheritance. Some patients present azoospermia or severe oligospermia without other clinical manifestations. {ECO:0000269|PubMed:10022458, ECO:0000269|PubMed:10221692, ECO:0000269|PubMed:10470409, ECO:0000269|PubMed:10502786, ECO:0000269|PubMed:10543676, ECO:0000269|PubMed:10690872, ECO:0000269|PubMed:11587068, ECO:0000269|PubMed:11788616, ECO:0000269|PubMed:1303262, ECO:0000269|PubMed:1307250, ECO:0000269|PubMed:1316540, ECO:0000269|PubMed:1424203, ECO:0000269|PubMed:1430233, ECO:0000269|PubMed:1458719, ECO:0000269|PubMed:14756668, ECO:0000269|PubMed:2010552, ECO:0000269|PubMed:7581399, ECO:0000269|PubMed:7649358, ECO:0000269|PubMed:7671849, ECO:0000269|PubMed:7909256, ECO:0000269|PubMed:7910529, ECO:0000269|PubMed:7929841, ECO:0000269|PubMed:7970939, ECO:0000269|PubMed:7981687, ECO:0000269|PubMed:8033918, ECO:0000269|PubMed:8097257, ECO:0000269|PubMed:8126121, ECO:0000269|PubMed:8205256, ECO:0000269|PubMed:8281139, ECO:0000269|PubMed:8325932, ECO:0000269|PubMed:8325950, ECO:0000269|PubMed:8339746, ECO:0000269|PubMed:8446106, ECO:0000269|PubMed:8550758, ECO:0000269|PubMed:8723113, ECO:0000269|PubMed:8809734, ECO:0000269|PubMed:8823308, ECO:0000269|PubMed:8824883, ECO:0000269|PubMed:9039340, ECO:0000269|PubMed:9196614, ECO:0000269|PubMed:9302173, ECO:0000269|PubMed:9329414, ECO:0000269|PubMed:9543136, ECO:0000269|PubMed:9607727, ECO:0000269|PubMed:9627582, ECO:0000269|PubMed:9768671, ECO:0000269|PubMed:9856504, ECO:0000269|Ref.126}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Hypospadias 1, X-linked (HYSP1) [MIM:300633]: A common malformation in which the urethra opens on the ventral side of the penis, due to developmental arrest of urethral fusion. The opening can be located glandular, penile, or even more posterior in the scrotum or perineum. Hypospadias is a feature of several syndromic disorders, including the androgen insensitivity syndrome and Opitz syndrome. {ECO:0000269|PubMed:8097257}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues (PubMed:19022849). Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19022849, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20812024, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:25091737}.; FUNCTION: [Isoform 3]: Lacks the C-terminal ligand-binding domain and therefore constitutively regulates the transcription of a specific set of canonical AR-target genes, including PSA/KLK3 and TMPRSS2, independently of steroid hormones (PubMed:19244107, PubMed:25008967). However, some genes are differentially regulated by full-length AR (isoform 1) and isoform 3. Isoform 3-specific target genes may be regulated independently of FOXA1 expression (PubMed:25008967). {ECO:0000269|PubMed:19244107, ECO:0000269|PubMed:25008967}.; FUNCTION: [Isoform 4]: Lacks the C-terminal ligand-binding domain and may therefore constitutively activate the transcription of a specific set of genes independently of steroid hormones. {ECO:0000269|PubMed:19244107}.
uniprot
proteins
mass_dalton
99188
uniprot
proteins
mutagenesis
MUTAGEN 83; /note="S->A: Reduced cell growth."; /evidence="ECO:0000269|PubMed:20980437"; MUTAGEN 225; /note="Y->F: Decrease of CSK-induced phosphorylation."; /evidence="ECO:0000269|PubMed:17045208"; MUTAGEN 269; /note="Y->F: Decrease of CSK-induced phosphorylation and phosphorylation by TNK2. Complete loss of TNK2-dependent phosphorylation; when associated with F-365."; /evidence="ECO:0000269|PubMed:17045208, ECO:0000269|PubMed:17494760"; MUTAGEN 309; /note="Y->F: Decrease of CSK-induced phosphorylation."; /evidence="ECO:0000269|PubMed:17045208"; MUTAGEN 348; /note="Y->F: Decrease of CSK-induced phosphorylation."; /evidence="ECO:0000269|PubMed:17045208"; MUTAGEN 359; /note="Y->F: Decrease of CSK-induced phosphorylation."; /evidence="ECO:0000269|PubMed:17045208"; MUTAGEN 364; /note="Y->F: Decrease of CSK-induced phosphorylation."; /evidence="ECO:0000269|PubMed:17045208"; MUTAGEN 365; /note="Y->F: Decrease of CSK-induced phosphorylation and phosphorylation by TNK2. Complete loss of TNK2-dependent phosphorylation; when associated with F-269."; /evidence="ECO:0000269|PubMed:17045208, ECO:0000269|PubMed:17494760"; MUTAGEN 395; /note="Y->F: Decrease of CSK-induced phosphorylation."; /evidence="ECO:0000269|PubMed:17045208"; MUTAGEN 535; /note="Y->F: Greatest decrease of CSK-induced phosphorylation and inhibition of transcriptional activity induced by EGF."; /evidence="ECO:0000269|PubMed:17045208"; MUTAGEN 552; /note="Y->F: Decrease in CSK-induced phosphorylation."; /evidence="ECO:0000269|PubMed:17045208"; MUTAGEN 702; /note="L->A: Alters receptor specificity, so that transcription is activated by the antiandrogen cyproterone acetate."; /evidence="ECO:0000269|PubMed:17311914"; MUTAGEN 721; /note="K->A: Loss of transcription activation in the presence of androgen and of interaction with NCOA2."; /evidence="ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767"; MUTAGEN 742; /note="W->L: Strongly decreased transcription activation in the presence of androgen."; /evidence="ECO:0000269|PubMed:16129672"; MUTAGEN 846; /note="K->R: Prevents ubiquitination by RNF6. Prevents AR transcriptional activation by RNF14 in absence of hormone."; /evidence="ECO:0000269|PubMed:19345326"; MUTAGEN 848; /note="K->R: Partially prevents ubiquitination by RNF6."; /evidence="ECO:0000269|PubMed:19345326"; MUTAGEN 898; /note="E->A,Q: Reduced transcription activation in the presence of androgen."; /evidence="ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767"; MUTAGEN 898; /note="E->K,R: Loss of transcription activation in the presence of androgen."; /evidence="ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767"; MUTAGEN 916; /note="Y->F: Decrease in CSK-induced phosphorylation."; /evidence="ECO:0000269|PubMed:17045208
uniprot
proteins
post_translational_modification
PTM: Sumoylated on Lys-388 (major) and Lys-521. Ubiquitinated. Deubiquitinated by USP26. 'Lys-6' and 'Lys-27'-linked polyubiquitination by RNF6 modulates AR transcriptional activity and specificity. {ECO:0000269|PubMed:11121022, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20501646}.; PTM: Phosphorylated in prostate cancer cells in response to several growth factors including EGF. Phosphorylation is induced by c-Src kinase (CSK). Tyr-535 is one of the major phosphorylation sites and an increase in phosphorylation and Src kinase activity is associated with prostate cancer progression. Phosphorylation by TNK2 enhances the DNA-binding and transcriptional activity and may be responsible for androgen-independent progression of prostate cancer. Phosphorylation at Ser-83 by CDK9 regulates AR promoter selectivity and cell growth. Phosphorylation by PAK6 leads to AR-mediated transcription inhibition. {ECO:0000269|PubMed:14573606, ECO:0000269|PubMed:17045208, ECO:0000269|PubMed:17494760, ECO:0000269|PubMed:20623637, ECO:0000269|PubMed:20980437, ECO:0000269|PubMed:21512132}.; PTM: Palmitoylated by ZDHHC7 and ZDHHC21. Palmitoylation is required for plasma membrane targeting and for rapid intracellular signaling via ERK and AKT kinases and cAMP generation. {ECO:0000269|PubMed:22031296}.
uniprot
proteins
protein_family
NR3 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
10022458
uniprot
proteins
pubmed
10075738
uniprot
proteins
pubmed
10092153
uniprot
proteins
pubmed
10221692
uniprot
proteins
pubmed
10221770
uniprot
proteins
pubmed
10332029
uniprot
proteins
pubmed
10359561
uniprot
proteins
pubmed
10363963
uniprot
proteins
pubmed
10383460
uniprot
proteins
pubmed
10400640
uniprot
proteins
pubmed
10404311
uniprot
proteins
pubmed
10425033
uniprot
proteins
pubmed
10458483
uniprot
proteins
pubmed
10470409
uniprot
proteins
pubmed
10502786
uniprot
proteins
pubmed
10543676
uniprot
proteins
pubmed
10569618
uniprot
proteins
pubmed
10571951
uniprot
proteins
pubmed
10590024
uniprot
proteins
pubmed
10598582
uniprot
proteins
pubmed
10625666
uniprot
proteins
pubmed
10629558
uniprot
proteins
pubmed
10690872
uniprot
proteins
pubmed
10706109
uniprot
proteins
pubmed
10840043
uniprot
proteins
pubmed
10930412
uniprot
proteins
pubmed
10946887
uniprot
proteins
pubmed
11121022
uniprot
proteins
pubmed
11231320
uniprot
proteins
pubmed
11587068
uniprot
proteins
pubmed
11744994
uniprot
proteins
pubmed
11788616
uniprot
proteins
pubmed
11906285
uniprot
proteins
pubmed
12039962
uniprot
proteins
pubmed
12361945
uniprot
proteins
pubmed
12415108
uniprot
proteins
pubmed
12612053
uniprot
proteins
pubmed
12958311
uniprot
proteins
pubmed
1303262
uniprot
proteins
pubmed
1307250
uniprot
proteins
pubmed
1316540
uniprot
proteins
pubmed
1424203
uniprot
proteins
pubmed
1426313
uniprot
proteins
pubmed
1430233
uniprot
proteins
pubmed
14573606
uniprot
proteins
pubmed
1458719
uniprot
proteins
pubmed
14609956
uniprot
proteins
pubmed
1464650
uniprot
proteins
pubmed
14664718
uniprot
proteins
pubmed
14756668
uniprot
proteins
pubmed
1480178
uniprot
proteins
pubmed
1487249
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15525515
uniprot
proteins
pubmed
15563469
uniprot
proteins
pubmed
1561105
uniprot
proteins
pubmed
1562539
uniprot
proteins
pubmed
15634333
uniprot
proteins
pubmed
1569163
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
15851746
uniprot
proteins
pubmed
15902657
uniprot
proteins
pubmed
16027218
uniprot
proteins
pubmed
16051670
uniprot
proteins
pubmed
1609793
uniprot
proteins
pubmed
16129672
uniprot
proteins
pubmed
1631125
uniprot
proteins
pubmed
16595706
uniprot
proteins
pubmed
16641486
uniprot
proteins
pubmed
16951154
uniprot
proteins
pubmed
17045208
uniprot
proteins
pubmed
17311914
uniprot
proteins
pubmed
17494760
uniprot
proteins
pubmed
17550981
uniprot
proteins
pubmed
17587566
uniprot
proteins
pubmed
17591767
uniprot
proteins
pubmed
17711855
uniprot
proteins
pubmed
1775137
uniprot
proteins
pubmed
17911242
uniprot
proteins
pubmed
18007036
uniprot
proteins
pubmed
18084323
uniprot
proteins
pubmed
18222118
uniprot
proteins
pubmed
18451096
uniprot
proteins
pubmed
18451177
uniprot
proteins
pubmed
1856263
uniprot
proteins
pubmed
19022849
uniprot
proteins
pubmed
19244107
uniprot
proteins
pubmed
19345326
uniprot
proteins
pubmed
19666546
uniprot
proteins
pubmed
19909775
uniprot
proteins
pubmed
1999491
uniprot
proteins
pubmed
2010552
uniprot
proteins
pubmed
20501646
uniprot
proteins
pubmed
20623637
uniprot
proteins
pubmed
2062380
uniprot
proteins
pubmed
20812024
uniprot
proteins
pubmed
2082179
uniprot
proteins
pubmed
20980437
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21512132
uniprot
proteins
pubmed
22031296
uniprot
proteins
pubmed
22170608
uniprot
proteins
pubmed
22334387
uniprot
proteins
pubmed
22406838
uniprot
proteins
pubmed
2260966
uniprot
proteins
pubmed
2293020
uniprot
proteins
pubmed
2342476
uniprot
proteins
pubmed
23487765
uniprot
proteins
pubmed
23887938
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24737579
uniprot
proteins
pubmed
25008967
uniprot
proteins
pubmed
25091737
uniprot
proteins
pubmed
2546571
uniprot
proteins
pubmed
2594783
uniprot
proteins
pubmed
27535533
uniprot
proteins
pubmed
2911578
uniprot
proteins
pubmed
2917688
uniprot
proteins
pubmed
3174628
uniprot
proteins
pubmed
3216866
uniprot
proteins
pubmed
3353726
uniprot
proteins
pubmed
3353727
uniprot
proteins
pubmed
33647767
uniprot
proteins
pubmed
3377788
uniprot
proteins
pubmed
7511268
uniprot
proteins
pubmed
7537149
uniprot
proteins
pubmed
7581399
uniprot
proteins
pubmed
7591265
uniprot
proteins
pubmed
7626493
uniprot
proteins
pubmed
7633398
uniprot
proteins
pubmed
7641413
uniprot
proteins
pubmed
7649358
uniprot
proteins
pubmed
7671849
uniprot
proteins
pubmed
7673412
uniprot
proteins
pubmed
7712463
uniprot
proteins
pubmed
7723794
uniprot
proteins
pubmed
7909256
uniprot
proteins
pubmed
7910529
uniprot
proteins
pubmed
7929841
uniprot
proteins
pubmed
7937057
uniprot
proteins
pubmed
7962294
uniprot
proteins
pubmed
7970939
uniprot
proteins
pubmed
7981687
uniprot
proteins
pubmed
7981689
uniprot
proteins
pubmed
7993455
uniprot
proteins
pubmed
8033918
uniprot
proteins
pubmed
8040309
uniprot
proteins
pubmed
8096390
uniprot
proteins
pubmed
8097257
uniprot
proteins
pubmed
8103398
uniprot
proteins
pubmed
8126121
uniprot
proteins
pubmed
8145761
uniprot
proteins
pubmed
8162033
uniprot
proteins
pubmed
8187068
uniprot
proteins
pubmed
8205256
uniprot
proteins
pubmed
8213813
uniprot
proteins
pubmed
8224266
uniprot
proteins
pubmed
8240973
uniprot
proteins
pubmed
8274409
uniprot
proteins
pubmed
8281139
uniprot
proteins
pubmed
8281140
uniprot
proteins
pubmed
8292051
uniprot
proteins
pubmed
8325932
uniprot
proteins
pubmed
8325950
uniprot
proteins
pubmed
8339746
uniprot
proteins
pubmed
8413310
uniprot
proteins
pubmed
8446106
uniprot
proteins
pubmed
8530589
uniprot
proteins
pubmed
8550758
uniprot
proteins
pubmed
8626869
uniprot
proteins
pubmed
8628719
uniprot
proteins
pubmed
8643607
uniprot
proteins
pubmed
8647313
uniprot
proteins
pubmed
8683794
uniprot
proteins
pubmed
8723113
uniprot
proteins
pubmed
8768864
uniprot
proteins
pubmed
8809734
uniprot
proteins
pubmed
8823308
uniprot
proteins
pubmed
8824883
uniprot
proteins
pubmed
8827083
uniprot
proteins
pubmed
8830623
uniprot
proteins
pubmed
8918984
uniprot
proteins
pubmed
8990010
uniprot
proteins
pubmed
9000575
uniprot
proteins
pubmed
9001799
uniprot
proteins
pubmed
9007482
uniprot
proteins
pubmed
9016528
uniprot
proteins
pubmed
9039340
uniprot
proteins
pubmed
9096391
uniprot
proteins
pubmed
9106550
uniprot
proteins
pubmed
9160185
uniprot
proteins
pubmed
9184448
uniprot
proteins
pubmed
9196614
uniprot
proteins
pubmed
9252933
uniprot
proteins
pubmed
9255042
uniprot
proteins
pubmed
9302173
uniprot
proteins
pubmed
9328206
uniprot
proteins
pubmed
9329414
uniprot
proteins
pubmed
9421404
uniprot
proteins
pubmed
9438000
uniprot
proteins
pubmed
9543136
uniprot
proteins
pubmed
9544375
uniprot
proteins
pubmed
9554754
uniprot
proteins
pubmed
9554755
uniprot
proteins
pubmed
9607727
uniprot
proteins
pubmed
9610419
uniprot
proteins
pubmed
9627582
uniprot
proteins
pubmed
9698822
uniprot
proteins
pubmed
9768671
uniprot
proteins
pubmed
9788719
uniprot
proteins
pubmed
9816170
uniprot
proteins
pubmed
9851768
uniprot
proteins
pubmed
9856504
uniprot
proteins
sequence_length
920
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12958311, ECO:0000269|PubMed:15634333, ECO:0000269|PubMed:17587566, ECO:0000269|PubMed:19244107, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:25091737}. Cytoplasm {ECO:0000269|PubMed:12958311, ECO:0000269|PubMed:17587566, ECO:0000269|PubMed:19244107}. Note=Detected at the promoter of target genes (PubMed:25091737). Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of RACK1. {ECO:0000269|PubMed:12958311, ECO:0000269|PubMed:17587566, ECO:0000269|PubMed:25091737}.
uniprot
proteins