Cops8
entrez
363283
canonical
uniprot
Q6P4Z9
canonical
ensembl
ENSRNOG00000019635
resolver
ensembl
ENSRNOG00055010316
resolver
ensembl
ENSRNOG00060010624
resolver
ensembl
ENSRNOG00065020475
resolver
ensp
ENSRNOP00000095164
resolver
ensp
ENSRNOP00055014050
resolver
ensp
ENSRNOP00060013998
resolver
ensp
ENSRNOP00065027768
resolver
enst
ENSRNOT00055017453
resolver
enst
ENSRNOT00060017993
resolver
enst
ENSRNOT00065034623
resolver
genesymbol
Cops8
resolver
genesymbol_syn
Csn8
resolver
uniprot_entry
CSN8_RAT
resolver
amino_acid_sequence
MPVAVMADNAFSFRKLLDQCENQELEAPGGIATPPVYGQLLALYLLQNDMNNARYLWKRIPPAIKSANSELGGIWSVGQRIWQRDFPGIYTTINAHQWSETVQPIMEALRDATRRRAFALVSQAYTSIIADDFAAFVGLPVEEAVKGVLEQGWQADSTTRMVLPRKPAPGALDVSLNRFIPLSEPAPVPPIPNEQQLARLTDYVAFLEN
uniprot
proteins
function
FUNCTION: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
23236
uniprot
proteins
protein_family
CSN8 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
209
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
uniprot
proteins