Pptc7
entrez
320717
canonical
uniprot
Q6NVE9
canonical
ensembl
ENSMUSG00000038582
resolver
ensp
ENSMUSP00000051838
resolver
genesymbol
Pptc7
resolver
genesymbol_syn
Tapp2c
resolver
uniprot
Q3TS53
resolver
uniprot
Q8BVC7
resolver
uniprot_entry
PPTC7_MOUSE
resolver
uniprot_sec
Q3TS53
resolver
uniprot_sec
Q8BVC7
resolver
amino_acid_sequence
MFSVLSYGRLVARAVLGGLSQTDPRAGGGGGGGGGSSGDYGLVTAGCGFGKDFRKGLLKKGACYGDDACFVARHRSADVLGVADGVGGWRDYGVDPSQFSGTLMRTCERLVKEGRFVPSNPVGILTTSYCELLQNKVPLLGSSTACIVVLDRSSHRLHTANLGDSGFLVVRGGEVVHRSDEQQHYFNTPFQLSIAPPEAEGVVLSDSPDAADSTSFDVQLGDIILTATDGLFDNMPDYMILQELKKLKNSNYESIQRTARSIAEQAHELAYDPNYMSPFAQFACDNGLNVRGGKPDDITVLLSIVAEYTD
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Protein phosphatase that plays an essential role in mitochondrial metabolism and biogenesis (PubMed:31324765). Positively regulates biosynthesis of the ubiquinone, coenzyme Q. Dephosphorylates the ubiquinone biosynthesis protein COQ7 which is likely to lead to its activation (By similarity). Serves as a crucial sensor for mitophagy, though the underlying mechanism remains ambiguous (PubMed:37833277, PubMed:38151018). May dephosphorylate BNIP3 and NIX and thereby directly regulates mitophagy receptor function and stability (PubMed:37833277). Alternatively, promotes SCF-FBXL4-dependent ubiquitination and degradation of BNIP3 and NIX independently of its catalytic activity to restrain mitophagy (PubMed:38151018). {ECO:0000250|UniProtKB:Q8NI37, ECO:0000269|PubMed:31324765, ECO:0000269|PubMed:37833277, ECO:0000269|PubMed:38151018}.
uniprot
proteins
mass_dalton
33048
uniprot
proteins
protein_family
PP2C family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31324765
uniprot
proteins
pubmed
37833277
uniprot
proteins
pubmed
38151018
uniprot
proteins
sequence_length
310
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:Q8NI37}.
uniprot
proteins