ADH7
entrez
131
canonical
uniprot
P40394
canonical
ensembl
ENSG00000196344
resolver
ensp
ENSP00000414254
resolver
ensp
ENSP00000420269
resolver
enst
ENST00000437033
resolver
genesymbol
ADH7
resolver
hgnc
HGNC:256
resolver
uniprot
A0A0C4DG85
resolver
uniprot
A2RRB6
resolver
uniprot
A8MVN9
resolver
uniprot
B2R760
resolver
uniprot
B4DWV6
resolver
uniprot
Q13713
resolver
uniprot_entry
A0A0C4DG85_HUMAN
resolver
uniprot_entry
ADH7_HUMAN
resolver
uniprot_sec
A2RRB6
resolver
uniprot_sec
A8MVN9
resolver
uniprot_sec
B2R760
resolver
uniprot_sec
B4DWV6
resolver
uniprot_sec
Q13713
resolver
activity_regulation
ACTIVITY REGULATION: Retinol oxidation is inhibited by the detergent Tween 80 (PubMed:15369820). Ethanol inhibits both all-trans-retinol and 9-cis-retinol oxidation (PubMed:9600267). 13-cis-retinol is an effective competitive inhibitor of the 9-cis-retinol oxidation (PubMed:9600267). All-trans-retinoic acid is a powerful inhibitor of all-trans-retinol oxidation (PubMed:9600267). 13-cis-retinoic acid is a powerful inhibitor of all-trans-retinol oxidation (PubMed:9600267). Cimetidine competitively inhibited ethanol oxidation (PubMed:9600267). {ECO:0000269|PubMed:15369820, ECO:0000269|PubMed:9600267}.
uniprot
proteins
amino_acid_sequence
MFAEIQIQDKDRMGTAGKVIKCKAAVLWEQKQPFSIEEIEVAPPKTKEVRIKILATGICRTDDHVIKGTMVSKFPVIVGHEATGIVESIGEGVTTVKPGDKVIPLFLPQCRECNACRNPDGNLCIRSDITGRGVLADGTTRFTCKGKPVHHFMNTSTFTEYTVVDESSVAKIDDAAPPEKVCLIGCGFSTGYGAAVKTGKVKPGSTCVVFGLGGVGLSVIMGCKSAGASRIIGIDLNKDKFEKAMAVGATECISPKDSTKPISEVLSEMTGNNVGYTFEVIGHLETMIDALASCHMNYGTSVVVGVPPSAKMLTYDPMLLFTGRTWKGCVFGGLKSRDDVPKLVTEFLAKKFDLDQLITHVLPFKKISEGFELLNSGQSIRTVLTF
uniprot
proteins
ec_number
1.1.1.1
uniprot
proteins
ec_number
1.1.1.105
uniprot
proteins
ec_number
1.1.1.66
uniprot
proteins
function
FUNCTION: Catalyzes the NAD-dependent oxidation of all-trans-retinol, alcohol, and omega-hydroxy fatty acids and their derivatives (PubMed:15369820, PubMed:16787387, PubMed:9600267). Oxidizes preferentially all trans-retinol, all-trans-4-hydroxyretinol, 9-cis-retinol, 2-hexenol, and long chain omega-hydroxy fatty acids such as juniperic acid (PubMed:15369820, PubMed:16787387, PubMed:9600267). In vitro can also catalyze the NADH-dependent reduction of all-trans-retinal and aldehydes and their derivatives (PubMed:15369820, PubMed:16787387, PubMed:9600267). Reduces preferentially all trans-retinal, all-trans-4-oxoretinal and hexanal (PubMed:15369820, PubMed:16787387). Catalyzes in the oxidative direction with higher efficiency (PubMed:15369820, PubMed:16787387). Therefore may participate in retinoid metabolism, fatty acid omega-oxidation, and elimination of cytotoxic aldehydes produced by lipid peroxidation (PubMed:15369820, PubMed:16787387, PubMed:9600267). {ECO:0000269|PubMed:15369820, ECO:0000269|PubMed:16787387, ECO:0000269|PubMed:9600267}.
uniprot
proteins
mass_dalton
41481
uniprot
proteins
protein_family
Class-IV subfamily
uniprot
proteins
protein_family
Zinc-containing alcohol dehydrogenase family
uniprot
proteins
pubmed
10631979
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15369820
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
1592118
uniprot
proteins
pubmed
16787387
uniprot
proteins
pubmed
7771649
uniprot
proteins
pubmed
7876099
uniprot
proteins
pubmed
7876191
uniprot
proteins
pubmed
7925371
uniprot
proteins
pubmed
8082805
uniprot
proteins
pubmed
8195208
uniprot
proteins
pubmed
8824810
uniprot
proteins
pubmed
9228021
uniprot
proteins
pubmed
9600267
uniprot
proteins
sequence_length
386
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins