NINL
entrez
22981
canonical
uniprot
Q9Y2I6
canonical
ensembl
ENSG00000101004
resolver
ensp
ENSP00000278886
resolver
ensp
ENSP00000559418
resolver
ensp
ENSP00000559419
resolver
ensp
ENSP00000631036
resolver
genesymbol
NINL
resolver
genesymbol_syn
KIAA0980
resolver
genesymbol_syn
NLP
resolver
hgnc
HGNC:29163
resolver
uniprot
A6NJN0
resolver
uniprot
B3V9H6
resolver
uniprot
B7Z1V8
resolver
uniprot
Q5JYP0
resolver
uniprot
Q8NE38
resolver
uniprot
Q9NQE3
resolver
uniprot_entry
NINL_HUMAN
resolver
uniprot_sec
A6NJN0
resolver
uniprot_sec
B3V9H6
resolver
uniprot_sec
B7Z1V8
resolver
uniprot_sec
Q5JYP0
resolver
uniprot_sec
Q8NE38
resolver
uniprot_sec
Q9NQE3
resolver
amino_acid_sequence
MDEEENHYVSQLREVYSSCDTTGTGFLDRQELTQLCLKLHLEQQLPVLLQTLLGNDHFARVNFEEFKEGFVAVLSSNAGVRPSDEDSSSLESAASSAIPPKYVNGSKWYGRRSRPELCDAATEARRVPEQQTQASLKSHLWRSASLESVESPKSDEEAESTKEAQNELFEAQGQLQTWDSEDFGSPQKSCSPSFDTPESQIRGVWEELGVGSSGHLSEQELAVVCQSVGLQGLEKEELEDLFNKLDQDGDGKVSLEEFQLGLFSHEPALLLESSTRVKPSKAWSHYQVPEESGCHTTTTSSLVSLCSSLRLFSSIDDGSGFAFPDQVLAMWTQEGIQNGREILQSLDFSVDEKVNLLELTWALDNELMTVDSAVQQAALACYHQELSYQQGQVEQLARERDKARQDLERAEKRNLEFVKEMDDCHSTLEQLTEKKIKHLEQGYRERLSLLRSEVEAERELFWEQAHRQRAALEWDVGRLQAEEAGLREKLTLALKENSRLQKEIVEVVEKLSDSERLALKLQKDLEFVLKDKLEPQSAELLAQEERFAAVLKEYELKCRDLQDRNDELQAELEGLWARLPKNRHSPSWSPDGRRRQLPGLGPAGISFLGNSAPVSIETELMMEQVKEHYQDLRTQLETKVNYYEREIAALKRNFEKERKDMEQARRREVSVLEGQKADLEELHEKSQEVIWGLQEQLQDTARGPEPEQMGLAPCCTQALCGLALRHHSHLQQIRREAEAELSGELSGLGALPARRDLTLELEEPPQGPLPRGSQRSEQLELERALKLQPCASEKRAQMCVSLALEEEELELARGKRVDGPSLEAEMQALPKDGLVAGSGQEGTRGLLPLRPGCGERPLAWLAPGDGRESEEAAGAGPRRRQAQDTEATQSPAPAPAPASHGPSERWSRMQPCGVDGDIVPKEPEPFGASAAGLEQPGARELPLLGTERDASQTQPRMWEPPLRPAASCRGQAERLQAIQEERARSWSRGTQEQASEQQARAEGALEPGCHKHSVEVARRGSLPSHLQLADPQGSWQEQLAAPEEGETKIALEREKDDMETKLLHLEDVVRALEKHVDLRENDRLEFHRLSEENTLLKNDLGRVRQELEAAESTHDAQRKEIEVLKKDKEKACSEMEVLNRQNQNYKDQLSQLNVRVLQLGQEASTHQAQNEEHRVTIQMLTQSLEEVVRSGQQQSDQIQKLRVELECLNQEHQSLQLPWSELTQTLEESQDQVQGAHLRLRQAQAQHLQEVRLVPQDRVAELHRLLSLQGEQARRRLDAQREEHEKQLKATEERVEEAEMILKNMEMLLQEKVDKLKEQFEKNTKSDLLLKELYVENAHLVRALQATEEKQRGAEKQSRLLEEKVRALNKLVSRIAPAALSV
uniprot
proteins
function
FUNCTION: Involved in the microtubule organization in interphase cells. Overexpression induces the fragmentation of the Golgi, and causes lysosomes to disperse toward the cell periphery; it also interferes with mitotic spindle assembly. Involved in vesicle transport in photoreceptor cells (By similarity). May play a role in ovarian carcinogenesis. {ECO:0000250|UniProtKB:G9G127, ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:16254247, ECO:0000269|PubMed:18538832}.
uniprot
proteins
mass_dalton
156344
uniprot
proteins
mutagenesis
MUTAGEN 495..497; /note="KEN->AAA: Disrupts binding to CDC20 and FZR1 and prevents ubiquitination and subsequent degradation of NINL; when associated with 633-A--A-636."; /evidence="ECO:0000269|PubMed:17403670"; MUTAGEN 633..636; /note="RTQL->AAAA: Disrupts binding to CDC20 and FZR1 and prevents ubiquitination and subsequent degradation of NINL; when associated with 495-A--A-497."; /evidence="ECO:0000269|PubMed:17403670
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PLK1 which disrupts its centrosome association and interaction with gamma-tubulin. {ECO:0000269|PubMed:12852856, ECO:0000269|PubMed:16254247}.; PTM: Ubiquitinated by the APC/C complex leading to its degradation. {ECO:0000269|PubMed:17403670}.
uniprot
proteins
pubmed
10231032
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12852856
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16254247
uniprot
proteins
pubmed
17403670
uniprot
proteins
pubmed
18538832
uniprot
proteins
pubmed
18826961
uniprot
proteins
pubmed
26485514
uniprot
proteins
sequence_length
1382
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:16254247, ECO:0000269|PubMed:26485514}. Cytoplasm {ECO:0000269|PubMed:16254247}. Note=In interphase cells, NINL is transported to the centrosomes by the dynein-dynactin motor complex (PubMed:16254247). During centrosome maturation, PLK1 directly phosphorylates NINL resulting in its release into the cytoplasm (PubMed:16254247).
uniprot
proteins