CLDN2
entrez
9075
canonical
uniprot
P57739
canonical
ensembl
ENSG00000165376
resolver
ensp
ENSP00000336571
resolver
ensp
ENSP00000441283
resolver
ensp
ENSP00000443230
resolver
ensp
ENSP00000569721
resolver
ensp
ENSP00000569722
resolver
ensp
ENSP00000569723
resolver
ensp
ENSP00000569724
resolver
enst
ENST00000336803
resolver
enst
ENST00000540876
resolver
enst
ENST00000541806
resolver
enst
ENST00000899662
resolver
enst
ENST00000899663
resolver
enst
ENST00000899664
resolver
enst
ENST00000899665
resolver
genesymbol
CLDN2
resolver
hgnc
HGNC:2041
resolver
uniprot
B2R6B9
resolver
uniprot_entry
CLD2_HUMAN
resolver
uniprot_sec
B2R6B9
resolver
amino_acid_sequence
MASLGLQLVGYILGLLGLLGTLVAMLLPSWKTSSYVGASIVTAVGFSKGLWMECATHSTGITQCDIYSTLLGLPADIQAAQAMMVTSSAISSLACIISVVGMRCTVFCQESRAKDRVAVAGGVFFILGGLLGFIPVAWNLHGILRDFYSPLVPDSMKFEIGEALYLGIISSLFSLIAGIILCFSCSSQRNRSNYYDAYQAQPLATRSSPRPGQPPKVKSEFNSYSLTGYV
uniprot
proteins
disease_involvement
DISEASE: Azoospermia, obstructive, with nephrolithiasis (OAZON) [MIM:301060]: An X-linked recessive, male infertility disorder characterized by epidydimal obstruction, hypercalciuria and kidney stones. {ECO:0000269|PubMed:31320686}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Forms paracellular channels: polymerizes in tight junction strands with cation- and water-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability (PubMed:20460438, PubMed:36008380). In intestinal epithelium, allows for sodium and water fluxes from the peritoneal side to the lumen of the intestine to regulate nutrient absorption and clear enteric pathogens as part of mucosal immune response (By similarity). In kidney, allows passive sodium and calcium reabsorption across proximal tubules from the lumen back to the bloodstream (By similarity). In the hepatobiliary tract, allows paracellular water and cation fluxes in the hepatic perivenous areas and biliary epithelium to generate bile flow and maintain osmotic gradients (By similarity). {ECO:0000250|UniProtKB:O88552, ECO:0000269|PubMed:20460438, ECO:0000269|PubMed:36008380}.
uniprot
proteins
mass_dalton
24549
uniprot
proteins
post_translational_modification
PTM: The disulfide bond is necessary for pore formation, but is not required for correct protein trafficking. {ECO:0000250|UniProtKB:O88552}.
uniprot
proteins
protein_family
Claudin family
uniprot
proteins
pubmed
11934881
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498874
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
20460438
uniprot
proteins
pubmed
22731716
uniprot
proteins
pubmed
31320686
uniprot
proteins
pubmed
36008380
uniprot
proteins
sequence_length
230
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000269|PubMed:20460438}. Cell membrane {ECO:0000250|UniProtKB:O88552}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 82..102; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 117..137; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 163..183; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins