Ogdhl
entrez
290566
canonical
uniprot
D3ZQD3
canonical
ensembl
ENSRNOG00000019955
resolver
ensp
ENSRNOP00000027054
resolver
genesymbol
Ogdhl
resolver
uniprot_entry
OGDHL_RAT
resolver
amino_acid_sequence
MSQLRLLLFRLGPQARKLLATRDIAAFGGRRRSSGPPTTIPRSRGGVSPSYVEEMYFAWLENPQSVHKSWDNFFQRATKEASVGPAQPQPPAVIQESRASVSSCTKTSKLVEDHLAVQSLIRAYQIRGHHVAQLDPLGILDADLDSFVPSDLITTIDKLAFYDLQEADLDKEFRLPTTTFIGGSENTLSLREIIRRLESTYCQHIGLEFMFINDVEQCQWIRQKFETPGVMKFSIEEKRTLLARLVRSMRFEDFLARKWSSEKRFGLEGCEVMIPALKTIIDKSSEMGVENVILGMPHRGRLNVLANVIRKDLEQIFCQFDPKLEAADEGSGDVKYHLGMYHERINRVTNRNITLSLVANPSHLEAVDPVVQGKTKAEQFYRGDAQGRKVMSILVHGDAAFAGQGVVYETFHLSDLPSYTTNGTVHVVVNNQIGFTTDPRMARSSPYPTDVARVVNAPIFHVNADDPEAVIYVCSVAAEWRNTFNKDVVVDLVCYRRRGHNEMDEPMFTQPLMYKQIHKQVPVLKKYADKLIAEGTVTLQEFEEEIAKYDRICEEAYGRSKDKKILHIKHWLDSPWPGFFNVDGEPKSMTYPTTGIPEDTLSHIGNVASSVPLEDFKIHTGLSRILRGRADMTKKRTVDWALAEYMAFGSLLKEGIHVRLSGQDVERGTFSHRHHVLHDQDVDRRTCVPMNHLWPDQAPYTVCNSSLSEYGVLGFELGYAMASPNALVLWEAQFGDFHNTAQCIIDQFISTGQAKWVRHNGIVLLLPHGMEGMGPEHSSARPERFLQMSNDDSDAYPVFTEDFEVSQLYDCNWIVVNCSTPASYFHVLRRQVLLPFRKPLIVFTPKSLLRHPDAKSSFDQMVSGTSFQRMIPEDGPAAQSPERVERLIFCTGKVYYDLVKERSSQGLEKQVAITRLEQISPFPFDLIMREAEKYSGAELVWCQEEHKNMGYYDYISPRFMTLLGHSRPIWYVGREPAAAPATGNKNTHLVSLRKFLDTAFNLKAFEGKTF
uniprot
proteins
ec_number
1.2.4.2
uniprot
proteins
function
FUNCTION: 2-oxoglutarate dehydrogenase (E1-like) component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDHC) which mediates the decarboxylation of alpha-ketoglutarate in the tricarboxylic acid cycle (PubMed:18783430). The OGDHC complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) while reducing NAD(+) to NADH (PubMed:18783430). The OGDHC complex is mainly active in the mitochondrion (PubMed:18783430). Involved in the inhibition of cell proliferation and in apoptosis (By similarity). {ECO:0000250|UniProtKB:Q9ULD0, ECO:0000305|PubMed:18783430}.
uniprot
proteins
mass_dalton
114637
uniprot
proteins
protein_family
Alpha-ketoglutarate dehydrogenase family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
18783430
uniprot
proteins
sequence_length
1010
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:Q9ULD0}.
uniprot
proteins