FAM76B
entrez
143684
canonical
uniprot
Q5HYJ3
canonical
ensembl
ENSG00000077458
resolver
ensp
ENSP00000351631
resolver
ensp
ENSP00000441168
resolver
ensp
ENSP00000444087
resolver
ensp
ENSP00000671745
resolver
enst
ENST00000536839
resolver
genesymbol
FAM76B
resolver
hgnc
HGNC:28492
resolver
uniprot
B2R9C2
resolver
uniprot
F5GX09
resolver
uniprot
Q6PIU3
resolver
uniprot
Q8TC53
resolver
uniprot_entry
F5GX09_HUMAN
resolver
uniprot_entry
FA76B_HUMAN
resolver
uniprot_sec
B2R9C2
resolver
uniprot_sec
Q6PIU3
resolver
uniprot_sec
Q8TC53
resolver
amino_acid_sequence
MAASALYACTKCTQRYPFEELSQGQQLCKECRIAHPIVKCTYCRSEFQQESKTNTICKKCAQNVKQFGTPKPCQYCNIIAAFIGTKCQRCTNSEKKYGPPQTCEQCKQQCAFDRKEEGRRKVDGKLLCWLCTLSYKRVLQKTKEQRKSLGSSHSNSSSSSLTEKDQHHPKHHHHHHHHHHRHSSSHHKISNLSPEEEQGLWKQSHKSSATIQNETPKKKPKLESKPSNGDSSSINQSADSGGTDNFVLISQLKEEVMSLKRLLQQRDQTILEKDKKLTELKADFQYQESNLRTKMNSMEKAHKETVEQLQAKNRELLKQVAALSKGKKFDKSGSILTSP
uniprot
proteins
function
FUNCTION: Negatively regulates the NF-kappa-B-mediated inflammatory pathway by preventing the translocation of HNRNPA2B1 from the nucleus to the cytoplasm (PubMed:37643469). Inhibits the PI3K/Akt/NF-kappa-B pathway-mediated polarization of M1 macrophages by binding to and stabilizing PIK3CD mRNA, resulting in increased levels of PIK3CD protein and increased levels of phosphorylated downstream target AKT which leads to decreased NF-kappa-B signaling (PubMed:38421448). {ECO:0000269|PubMed:37643469, ECO:0000269|PubMed:38421448}.
uniprot
proteins
mass_dalton
38708
uniprot
proteins
protein_family
FAM76 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19266028
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
27018871
uniprot
proteins
pubmed
37643469
uniprot
proteins
pubmed
38421448
uniprot
proteins
sequence_length
339
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000269|PubMed:19266028, ECO:0000269|PubMed:27018871}.
uniprot
proteins