Pip4p2
entrez
362490
canonical
uniprot
Q4V888
canonical
ensembl
ENSRNOG00000006697
resolver
ensembl
ENSRNOG00055000327
resolver
ensembl
ENSRNOG00060017480
resolver
ensembl
ENSRNOG00065015743
resolver
ensp
ENSRNOP00000009375
resolver
ensp
ENSRNOP00055000434
resolver
ensp
ENSRNOP00060024088
resolver
ensp
ENSRNOP00065020560
resolver
enst
ENSRNOT00000009375
resolver
enst
ENSRNOT00055000571
resolver
enst
ENSRNOT00060029878
resolver
enst
ENSRNOT00065026143
resolver
genesymbol
Pip4p2
resolver
genesymbol_syn
Tmem55a
resolver
uniprot_entry
PP4P2_RAT
resolver
amino_acid_sequence
MAADGVDERSPLLSASHSGNVTPTAPPYLQESSPRAELPPPYTAIASPGTSGIPVINCRVCQSLINLDGKLHQHVVKCTVCNEATPIKTPPTGKKYVRCPCNCLLICKDTSRRIGCPRPNCRRIINLGPIMLISEEQPAQPALPVQPEGTRVVCGHCGNTFLWMELRFNTLAKCPHCKKISSVGSALPRRRCCAYVTIGMICIFIGVGLTVGTQDFSRRFHATYVSWAIAYLLGLICLIRACYWGAIRVSYPEHGFA
uniprot
proteins
ec_number
3.1.3.78
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P) (By similarity). Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate (By similarity). Negatively regulates the phagocytosis of large particles by reducing phagosomal phosphatidylinositol 4,5-bisphosphate accumulation during cup formation (By similarity). {ECO:0000250|UniProtKB:Q8N4L2, ECO:0000250|UniProtKB:Q9CZX7}.
uniprot
proteins
mass_dalton
28024
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
257
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Late endosome membrane {ECO:0000250|UniProtKB:Q8N4L2}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:Q8N4L2}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q9CZX7}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9CZX7}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 192..212; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 227..247; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins