COX7A1
entrez
1346
canonical
uniprot
P24310
canonical
ensembl
ENSG00000161281
resolver
ensp
ENSP00000292907
resolver
enst
ENST00000292907
resolver
genesymbol
COX7A1
resolver
genesymbol_syn
COX7AH
resolver
hgnc
HGNC:2287
resolver
uniprot
Q6FGI7
resolver
uniprot_entry
CX7A1_HUMAN
resolver
uniprot_entry
Q6FGI7_HUMAN
resolver
amino_acid_sequence
MQALRVSQALIRSFSSTARNRFQNRVREKQKLFQEDNDIPLYLKGGIVDNILYRVTMTLCLGGTVYSLYSLGWASFPRN
uniprot
proteins
function
FUNCTION: Component of the mitochondrial respiratory complex IV (CIV, also named cytochrome c oxidase complex), the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation (By similarity). The CIV complex is the component of the respiratory chain that catalyzes the reduction of oxygen to water (By similarity). Acts as an assembly factor that specifically drives the homodimerization of CIV complexes, mediating the formation of mitochondrial respiratory supercomplexes (respirasomes) containing two CIV: supercomplxes with two molecules of CIV show improved activity (By similarity). Despite being highly expressed in brown adipose tissue, not required for thermogenesis (By similarity). {ECO:0000250|UniProtKB:P10174, ECO:0000250|UniProtKB:P56392, ECO:0000250|UniProtKB:Q08CE7}.
uniprot
proteins
mass_dalton
9118
uniprot
proteins
pathway_participation
PATHWAY: Energy metabolism; oxidative phosphorylation. {ECO:0000250|UniProtKB:P56392}.
uniprot
proteins
protein_family
Cytochrome c oxidase VIIa family
uniprot
proteins
pubmed
10335655
uniprot
proteins
pubmed
11997101
uniprot
proteins
pubmed
1309697
uniprot
proteins
pubmed
1327965
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9344674
uniprot
proteins
sequence_length
79
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P07470}; Single-pass membrane protein {ECO:0000250|UniProtKB:P07470}.
uniprot
proteins
transmembrane_region
TRANSMEM 47..75; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P07470
uniprot
proteins