Ccr2
entrez
60463
canonical
uniprot
O55193
canonical
ensembl
ENSRNOG00000063127
resolver
ensembl
ENSRNOG00055002417
resolver
ensembl
ENSRNOG00060023353
resolver
ensembl
ENSRNOG00065000759
resolver
ensp
ENSRNOP00000081733
resolver
ensp
ENSRNOP00000095594
resolver
ensp
ENSRNOP00000100016
resolver
ensp
ENSRNOP00000102774
resolver
ensp
ENSRNOP00055002887
resolver
ensp
ENSRNOP00055002889
resolver
ensp
ENSRNOP00060033381
resolver
ensp
ENSRNOP00060033413
resolver
ensp
ENSRNOP00065000788
resolver
ensp
ENSRNOP00065000789
resolver
enst
ENSRNOT00000100998
resolver
enst
ENSRNOT00000114724
resolver
enst
ENSRNOT00000128102
resolver
enst
ENSRNOT00000155229
resolver
enst
ENSRNOT00055003839
resolver
enst
ENSRNOT00055003841
resolver
enst
ENSRNOT00060040410
resolver
enst
ENSRNOT00060040443
resolver
enst
ENSRNOT00065001048
resolver
enst
ENSRNOT00065001049
resolver
genesymbol
Ccr2
resolver
genesymbol_syn
Cmkbr2
resolver
uniprot_entry
CCR2_RAT
resolver
amino_acid_sequence
MEDSNMLPQFIHGILSTSHSLFPRSIQELDEGATTPYDYDDGEPCHKTSVKQIGAWILPPLYSLVFIFGFVGNMLVIIILISCKKLKSMTDIYLFNLAISDLLFLLTLPFWAHYAANEWVFGNIMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVITSVVTWVVAVFASLPGIIFTKSEQEDDQHTCGPYFPTIWKNFQTIMRNILSLILPLLVMVICYSGILHTLFRCRNEKKRHRAVRLIFAIMIVYFLFWTPYNIVLFLTTFQEFLGMSNCVVDMHLDQAMQVTETLGMTHCCVNPIIYAFVGEKFRRYLSIFFRKHIAKNLCKQCPVFYRETADRVSSTFTPSTGEQEVSVGL
uniprot
proteins
function
FUNCTION: Key functional receptor for CCL2 but can also bind CCL7 and CCL12 (By similarity). Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (By similarity). Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B (By similarity). Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation (By similarity). Facilitates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression; signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity). Mediates the recruitment of macrophages and monocytes to the injury site following brain injury (By similarity). {ECO:0000250|UniProtKB:P41597, ECO:0000250|UniProtKB:P51683}.
uniprot
proteins
mass_dalton
42763
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:P41597}.; PTM: Sulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form (By similarity). Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer (By similarity). {ECO:0000250|UniProtKB:P41597}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
9655467
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P41597}; Multi-pass membrane protein {ECO:0000255}. Note=The chemoattractant receptors are distributed throughout the cell surface; after stimulation with a ligand, such as CCL2, they are rapidly recruited into microdomain clusters at the cell membrane. {ECO:0000250|UniProtKB:P41597}.
uniprot
proteins
transmembrane_region
TRANSMEM 61..81; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 92..112; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 129..149; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 171..191; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 221..241; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 257..277; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 302..322; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins