AKNA
entrez
80709
canonical
uniprot
Q7Z591
canonical
ensembl
ENSG00000106948
resolver
ensp
ENSP00000303769
resolver
ensp
ENSP00000309222
resolver
ensp
ENSP00000363188
resolver
ensp
ENSP00000363201
resolver
ensp
ENSP00000572459
resolver
ensp
ENSP00000572460
resolver
genesymbol
AKNA
resolver
genesymbol_syn
KIAA1968
resolver
hgnc
HGNC:24108
resolver
uniprot
Q05BK5
resolver
uniprot
Q5T535
resolver
uniprot
Q5T536
resolver
uniprot
Q5T537
resolver
uniprot
Q64FX6
resolver
uniprot
Q64FX7
resolver
uniprot
Q64FX8
resolver
uniprot
Q64FY1
resolver
uniprot
Q64FY2
resolver
uniprot
Q6ZMK0
resolver
uniprot
Q6ZNL2
resolver
uniprot
Q6ZTX0
resolver
uniprot
Q8TET1
resolver
uniprot
Q8TF33
resolver
uniprot
Q96RR9
resolver
uniprot
Q9H7P7
resolver
uniprot_entry
AKNA_HUMAN
resolver
uniprot_entry
Q64FY1_HUMAN
resolver
uniprot_sec
Q05BK5
resolver
uniprot_sec
Q5T535
resolver
uniprot_sec
Q5T536
resolver
uniprot_sec
Q5T537
resolver
uniprot_sec
Q64FX6
resolver
uniprot_sec
Q64FX7
resolver
uniprot_sec
Q64FX8
resolver
uniprot_sec
Q64FY2
resolver
uniprot_sec
Q6ZMK0
resolver
uniprot_sec
Q6ZNL2
resolver
uniprot_sec
Q6ZTX0
resolver
uniprot_sec
Q8TET1
resolver
uniprot_sec
Q8TF33
resolver
uniprot_sec
Q96RR9
resolver
uniprot_sec
Q9H7P7
resolver
amino_acid_sequence
MASSETEIRWAEPGLGKGPQRRRWAWAEDKRDVDRSSSQSWEEERLFPNATSPELLEDFRLAQQHLPPLEWDPHPQPDGHQDSESGETSGEEAEAEDVDSPASSHEPLAWLPQQGRQLDMTEEEPDGTLGSLEVEEAGESSSRLGYEAGLSLEGHGNTSPMALGHGQARGWVASGEQASGDKLSEHSEVNPSVELSPARSWSSGTVSLDHPSDSLDSTWEGETDGPQPTALAETLPEGPSHHLLSPDGRTGGSVARATPMEFQDSSAPPAQSPQHATDRWRRETTRFFCPQPKEHIWKQTKTSPKPLPSRFIGSISPLNPQPRPTRQGRPLPRQGATLAGRSSSNAPKYGRGQLNYPLPDFSKVGPRVRFPKDESYRPPKSRSHNRKPQAPARPLIFKSPAEIVQEVLLSSGEAALAKDTPPAHPITRVPQEFQTPEQATELVHQLQEDYHRLLTKYAEAENTIDQLRLGAKVNLFSDPPQPNHSIHTGMVPQGTKVLSFTIPQPRSAEWWPGPAEDPQASAASGWPSARGDLSPSSLTSMPTLGWLPENRDISEDQSSAEQTQALASQASQFLAKVESFERLIQAGRLMPQDQVKGFQRLKAAHAALEEEYLKACREQHPAQPLAGSKGTPGRFDPRRELEAEIYRLGSCLEELKEHIDQTQQEPEPPGSDSALDSTPALPCLHQPTHLPAPSGQAPMPAIKTSCPEPATTTAAASTGPCPLHVNVEVSSGNSEVEDRPQDPLARLRHKELQMEQVYHGLMERYLSVKSLPEAMRMEEEEEGEEEEEEEGGGDSLEVDGVAATPGKAEATRVLPRQCPVQAEKSHGAPLEEATEKMVSMKPPGFQASLARDGHMSGLGKAEAAPPGPGVPPHPPGTKSAASHQSSMTSLEGSGISERLPQKPLHRGGGPHLEETWMASPETDSGFVGSETSRVSPLTQTPEHRLSHISTAGTLAQPFAASVPRDGASYPKARGSLIPRRATEPSTPRSQAQRYLSSPSGPLRQRAPNFSLERTLAAEMAVPGSEFEGHKRISEQPLPNKTISPPPAPAPAAAPLPCGPTETIPSFLLTRAGRDQAICELQEEVSRLRLRLEDSLHQPLQGSPTRPASAFDRPARTRGRPADSPATWGSHYGSKSTERLPGEPRGEEQIVPPGRQRARSSSVPREVLRLSLSSESELPSLPLFSEKSKTTKDSPQAARDGKRGVGSAGWPDRVTFRGQYTGHEYHVLSPKAVPKGNGTVSCPHCRPIRTQDAGGAVTGDPLGPPPADTLQCPLCGQVGSPPEADGPGSATSGAEKATTRRKASSTPSPKQRSKQAGSSPRPPPGLWYLATAPPAPAPPAFAYISSVPIMPYPPAAVYYAPAGPTSAQPAAKWPPTASPPPARRHRHSIQLDLGDLEELNKALSRAVQAAESVRSTTRQMRSSLSADLRQAHSLRGSCLF
uniprot
proteins
function
FUNCTION: Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (By similarity). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (By similarity). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (By similarity). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (By similarity). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (PubMed:11268217). Binds to A/T-rich promoters (PubMed:11268217). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidence is required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q80VW7, ECO:0000269|PubMed:11268217, ECO:0000305}.
uniprot
proteins
mass_dalton
155139
uniprot
proteins
post_translational_modification
PTM: Phosphorylated; phosphorylation regulates dissociation from and reassembly at the centrosome. {ECO:0000250|UniProtKB:Q80VW7}.
uniprot
proteins
protein_family
AKNA family
uniprot
proteins
pubmed
11268217
uniprot
proteins
pubmed
11853319
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15869410
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
1439
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q80VW7}. Nucleus {ECO:0000269|PubMed:11268217}. Note=Localizes to the distal part of the subdistal appendages of the mother centriole in interphase. Also found at the proximal ends of centrioles and along microtubules. The centrosomal localization is dependent on centrioles. Dissociates from centrosomes during M-phase without proteolytic degradation and reassembles at the centrosomes during late telophase and early G1 phase. Dissociation and reassembly is regulated by phosphorylation. {ECO:0000250|UniProtKB:Q80VW7}.
uniprot
proteins