Pja2
entrez
192256
canonical
uniprot
Q63364
canonical
ensembl
ENSRNOG00000015528
resolver
ensembl
ENSRNOG00055019733
resolver
ensembl
ENSRNOG00060001654
resolver
ensembl
ENSRNOG00065019134
resolver
ensp
ENSRNOP00000021258
resolver
ensp
ENSRNOP00000072362
resolver
ensp
ENSRNOP00055027330
resolver
ensp
ENSRNOP00060001622
resolver
ensp
ENSRNOP00065025688
resolver
enst
ENSRNOT00000021258
resolver
enst
ENSRNOT00000080962
resolver
enst
ENSRNOT00055033681
resolver
enst
ENSRNOT00060002499
resolver
enst
ENSRNOT00065032178
resolver
genesymbol
Pja2
resolver
genesymbol_syn
Neurodap1
resolver
uniprot
A0A0H2UHM9
resolver
uniprot_entry
A0A0H2UHM9_RAT
resolver
uniprot_entry
PJA2_RAT
resolver
amino_acid_sequence
MSQYTEKEPSVMDQDSSKAAWPRAAGGYQTITGRRYGRRHAYVSFKPCMTRHERSLGRAGDDYEVLELDDVAKENTAGSSSLDQVHPSLPSETTVEKSETEIPTCGPALNQSTESNPSVATVCHSEEVRETLDSSTNLQNHAERECTPAVCNASSVQNGIVLVHTDSYDPDSKHDENDSLQLCAQAVEGGRRQKVLGNAVFELENGEVERYADLCPSVPSLSGEIREESEELGSALLEKNSAGDAEAVHQDGQEFQRSSEDGIVRKRRQDDTDQGRQTENSTEDADCVPGHVEQNTSERANHHGSSPEQVVRPKVRKVISSSQVDQESGFNRHEAKQRSVQRWREALEVEECSSDDPIIKCDDYDGDHDCMFLTPSYSRVTPREAERHRATAENGATASGRQEARENAFWNACGEYYQLFDKDEDSSECSDGEWSASLPHRFSGTEKDQSSSDESWETLPGKDENEPELQSDSSGPEEENQELSLQEGEQTSLEEGEIPWLQYNEVNESSSDEGNEPANEFAQPEAFMLDGNNNLEDDSSVSEDLDVDWSLFDGFADGLGVAEAISYVDPQFLTYMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDGLPETLVLEDHTAIGQEQCCPICCSEYIKDDIATELPCHHFFHKPCVSIWLQKSGTCPVCRRHFPPAVIDASAAASSEPDLDASPANDNAEEAP
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes (PubMed:21423175). Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype. Plays a role in ciliogenesis by ubiquitinating OFD1 (By similarity). {ECO:0000250|UniProtKB:O43164, ECO:0000269|PubMed:21423175}.
uniprot
proteins
mass_dalton
77921
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:O43164}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21423175
uniprot
proteins
pubmed
7623148
uniprot
proteins
sequence_length
707
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:7623148}. Cell membrane {ECO:0000250|UniProtKB:O43164}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:7623148}; Peripheral membrane protein {ECO:0000269|PubMed:7623148}. Golgi apparatus membrane {ECO:0000269|PubMed:7623148}; Peripheral membrane protein {ECO:0000269|PubMed:7623148}. Synapse {ECO:0000269|PubMed:7623148}. Postsynaptic density {ECO:0000269|PubMed:7623148}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:O43164}. Note=Localizes at the cytoplasmic side of endoplasmic reticulum and Golgi apparatus (By similarity). Expressed in the postsynaptic density region of synapses (PubMed:7623148). Colocalizes with PRKAR2A and PRKAR2B in the cytoplasm and the cell membrane (By similarity). {ECO:0000250|UniProtKB:O43164, ECO:0000269|PubMed:7623148}.
uniprot
proteins