OLFM2
entrez
93145
canonical
uniprot
O95897
canonical
ensembl
ENSG00000105088
resolver
ensp
ENSP00000264833
resolver
ensp
ENSP00000464877
resolver
ensp
ENSP00000465809
resolver
enst
ENST00000264833
resolver
enst
ENST00000590841
resolver
enst
ENST00000593091
resolver
genesymbol
OLFM2
resolver
genesymbol_syn
NOE2
resolver
hgnc
HGNC:17189
resolver
uniprot
K7EIS8
resolver
uniprot
K7EKW2
resolver
uniprot
Q6IMJ3
resolver
uniprot
Q96FC2
resolver
uniprot_entry
K7EIS8_HUMAN
resolver
uniprot_entry
K7EKW2_HUMAN
resolver
uniprot_entry
NOE2_HUMAN
resolver
uniprot_sec
Q6IMJ3
resolver
uniprot_sec
Q96FC2
resolver
amino_acid_sequence
MWPLTVPPPLLLLLCSGLAGQTLFQNPEEGWQLYTSAQAPDGKCICTAVIPAQSTCSRDGRSRELRQLMEKVQNVSQSMEVLELRTYRDLQYVRGMETLMRSLDARLRAADGSLSAKSFQELKDRMTELLPLSSVLEQYKADTRTIVRLREEVRNLSGSLAAIQEEMGAYGYEDLQQRVMALEARLHACAQKLGCGKLTGVSNPITVRAMGSRFGSWMTDTMAPSADSRVWYMDGYYKGRRVLEFRTLGDFIKGQNFIQHLLPQPWAGTGHVVYNGSLFYNKYQSNVVVKYHFRSRSVLVQRSLPGAGYNNTFPYSWGGFSDMDFMVDESGLWAVYTTNQNAGNIVVSRLDPHTLEVMRSWDTGYPKRSAGEAFMICGVLYVTNSHLAGAKVYFAYFTNTSSYEYTDVPFHNQYSHISMLDYNPRERALYTWNNGHQVLYNVTLFHVISTSGDP
uniprot
proteins
function
FUNCTION: Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation. TGF-beta induces expression and translocation of OLFM2 to the nucleus where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes (PubMed:25298399). Plays a role in AMPAR complex organization (By similarity). Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling (By similarity). {ECO:0000250|UniProtKB:Q568Y7, ECO:0000250|UniProtKB:Q8BM13, ECO:0000269|PubMed:25298399}.
uniprot
proteins
mass_dalton
51386
uniprot
proteins
mutagenesis
MUTAGEN 144; /note="R->Q: No effect on secretion."; /evidence="ECO:0000269|PubMed:21228389"; MUTAGEN 420; /note="L->S: Completely blocks secretion. Also significantly inhibits secretion of OLFM1 and OLFM3."; /evidence="ECO:0000269|PubMed:21228389
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:21228389}.
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15123989
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
21228389
uniprot
proteins
pubmed
25298399
uniprot
proteins
pubmed
27844144
uniprot
proteins
sequence_length
454
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21228389}. Synapse {ECO:0000250|UniProtKB:Q8BM13}. Membrane {ECO:0000250|UniProtKB:Q8BM13}. Nucleus {ECO:0000269|PubMed:25298399}. Cytoplasm {ECO:0000269|PubMed:25298399}. Note=Nuclear localization is induced by TGF-beta. {ECO:0000269|PubMed:25298399}.
uniprot
proteins