Pax4
entrez
18506
canonical
uniprot
P32115
canonical
ensembl
ENSMUSG00000029706
resolver
ensp
ENSMUSP00000031718
resolver
ensp
ENSMUSP00000126000
resolver
ensp
ENSMUSP00000131301
resolver
enst
ENSMUST00000171089
resolver
genesymbol
Pax4
resolver
genesymbol_syn
Pax-4
resolver
uniprot
A2RRY5
resolver
uniprot
B7ZNC7
resolver
uniprot
B7ZNC8
resolver
uniprot
F7AFR4
resolver
uniprot
P97341
resolver
uniprot
Q9QUR1
resolver
uniprot
Q9R091
resolver
uniprot_entry
A2RRY5_MOUSE
resolver
uniprot_entry
B7ZNC8_MOUSE
resolver
uniprot_entry
F7AFR4_MOUSE
resolver
uniprot_entry
PAX4_MOUSE
resolver
uniprot_sec
B7ZNC7
resolver
uniprot_sec
P97341
resolver
uniprot_sec
Q9QUR1
resolver
uniprot_sec
Q9R091
resolver
amino_acid_sequence
MQQDGLSSVNQLGGLFVNGRPLPLDTRQQIVQLAIRGMRPCDISRSLKVSNGCVSKILGRYYRTGVLEPKCIGGSKPRLATPAVVARIAQLKDEYPALFAWEIQHQLCTEGLCTQDKAPSVSSINRVLRALQEDQSLHWTQLRSPAVLAPVLPSPHSNCGAPRGPHPGTSHRNRTIFSPGQAEALEKEFQRGQYPDSVARGKLAAATSLPEDTVRVWFSNRRAKWRRQEKLKWEAQLPGASQDLTVPKNSPGIISAQQSPGSVPSAALPVLEPLSPSFCQLCCGTAPGRCSSDTSSQAYLQPYWDCQSLLPVASSSYVEFAWPCLTTHPVHHLIGGPGQVPSTHCSNWP
uniprot
proteins
function
FUNCTION: DNA-binding transcription factor that plays a central role in the differentiation and development of type B pancreatic cells, which are located within the pancreatic islets of Langerhans responsible for the production and release of insulin (PubMed:10364449, PubMed:10567552, PubMed:10891400, PubMed:15930104, PubMed:19665969, PubMed:9121556). Mainly acts as a transcription repressor that binds to a common element in the glucagon, insulin and somatostatin promoters and inhibits their expression (PubMed:10567552, PubMed:10891400). Prevents differentiation of type A pancreatic cells, probably by repressing expression of ARX (PubMed:14561778). Competes with another transcription factor, PAX6, for this same promoter binding site (PubMed:10364449). Also plays a key role in intestinal enteroendocrine cell differentiation by (1) directly promoting differentiation of enterochromaffin cells and (2) preventing differentiation of other intestinal enteroendocrine cell types (PubMed:22570716). Prevents differentiation of other intestinal enteroendocrine cell types by repressing the expression of ARX, the master transcription factor for intestinal type-L, -N, -D, -I and -G enteroendocrine cell differentiation (By similarity). {ECO:0000250|UniProtKB:O43316, ECO:0000269|PubMed:10364449, ECO:0000269|PubMed:10567552, ECO:0000269|PubMed:10891400, ECO:0000269|PubMed:14561778, ECO:0000269|PubMed:15930104, ECO:0000269|PubMed:19665969, ECO:0000269|PubMed:22570716, ECO:0000269|PubMed:9121556}.
uniprot
proteins
mass_dalton
38008
uniprot
proteins
mutagenesis
MUTAGEN 272..273; /note="EP->DL: Loss of transactivation function."; /evidence="ECO:0000269|PubMed:10364449
uniprot
proteins
protein_family
Paired homeobox family
uniprot
proteins
pubmed
10364449
uniprot
proteins
pubmed
10567552
uniprot
proteins
pubmed
10567553
uniprot
proteins
pubmed
10891400
uniprot
proteins
pubmed
14561778
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15930104
uniprot
proteins
pubmed
1685142
uniprot
proteins
pubmed
19665969
uniprot
proteins
pubmed
22570716
uniprot
proteins
pubmed
9121556
uniprot
proteins
pubmed
9439631
uniprot
proteins
pubmed
9480859
uniprot
proteins
sequence_length
349
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:10567552}. Chromosome {ECO:0000305|PubMed:10567552}.
uniprot
proteins