Lmod2
entrez
93677
canonical
uniprot
Q3UHZ5
canonical
ensembl
ENSMUSG00000029683
resolver
ensp
ENSMUSP00000031694
resolver
enst
ENSMUST00000031694
resolver
genesymbol
Lmod2
resolver
uniprot
Q99PM7
resolver
uniprot_entry
LMOD2_MOUSE
resolver
uniprot_sec
Q99PM7
resolver
amino_acid_sequence
MSTFGYRRGLSKYESIDEDELLASLSPEELKELERELEDIEPDRNLPVGLRQKSLTEKTPTGNFSREALMAYWEKESQKLLEKERLGECGKVAEEDKEESEEELIFTESNSEVSEEVCTEDEEESQEEEEDSEEEEDSEEEEETTEATKHINGTVSYNSVNTDNSKPKTFKSQIENINLTNGNSGRTQRNSESPAAIHPCGNPTVIEDALEKIRNNDPDTTEVNLNNIENITTQTLSRFAEALKENTVVKTFSLANTHADDAAAIAIADMLKVNEHITSVNVESNFITGKGILAIMRALQHNTVLTELRFHNQRHIMGSQVEMEIVKLLKENTTLLRLGYHFELPGPRMSMTSILTRNMDKQRQKRMQEQKQQEGHDGGAALRTKVWQRGTPGSSPYASPRQSPWSSPKVSKKVHTGRSRPPSPVAPPPPPPPPPLPPHMLPPPPPPPAPPLPEKKLITRNIAEVIKQQESAQRALQNGQRKKKGKKVKKQPNNILKEIKNSLRSVQEKKMEDSSRPSTPQRSVHENLMEAIRGSSIRQLRRVEVPEALR
uniprot
proteins
function
FUNCTION: Mediates nucleation of actin filaments and thereby promotes actin polymerization (By similarity). Plays a role in the regulation of actin filament length (PubMed:26487682). Required for normal sarcomere organization in the heart, and for normal heart function (PubMed:26487682, PubMed:27274810). {ECO:0000250|UniProtKB:Q6P5Q4, ECO:0000269|PubMed:26487682, ECO:0000269|PubMed:27274810}.
uniprot
proteins
mass_dalton
62018
uniprot
proteins
mutagenesis
MUTAGEN 405..550; /note="Missing: When expressed in constitutive LMOD2 knockout mice, the mutant reduces onset of cardiac dilation and dysfunction.
uniprot
proteins
protein_family
Tropomodulin family
uniprot
proteins
pubmed
11318603
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17572376
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26487682
uniprot
proteins
pubmed
27274810
uniprot
proteins
pubmed
31517052
uniprot
proteins
pubmed
37126682
uniprot
proteins
sequence_length
550
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:Q6P5Q4}. Cytoplasm, myofibril {ECO:0000250|UniProtKB:Q6P5Q4}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250|UniProtKB:Q6P5Q4}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q6P5Q4}. Note=Colocalizes with actin filaments in sarcomeres. Detected close to the M line. {ECO:0000250|UniProtKB:Q6P5Q4}.
uniprot
proteins