Gucy1a2
entrez
66012
canonical
uniprot
Q9WVI4
canonical
ensembl
ENSRNOG00000029876
resolver
ensembl
ENSRNOG00055006026
resolver
ensembl
ENSRNOG00060015826
resolver
ensembl
ENSRNOG00065002755
resolver
ensp
ENSRNOP00000098928
resolver
ensp
ENSRNOP00055007523
resolver
ensp
ENSRNOP00060021733
resolver
ensp
ENSRNOP00065002645
resolver
enst
ENSRNOT00000170498
resolver
enst
ENSRNOT00055009757
resolver
enst
ENSRNOT00060027104
resolver
enst
ENSRNOT00065003767
resolver
genesymbol
Gucy1a2
resolver
uniprot
Q54A43
resolver
uniprot_entry
GCYA2_RAT
resolver
uniprot_sec
Q54A43
resolver
activity_regulation
ACTIVITY REGULATION: Activated by nitric oxide in the presence of magnesium or manganese ions. {ECO:0000269|PubMed:11121588}.
uniprot
proteins
amino_acid_sequence
MSRRKISSESFSSLGSDYLETSPEEEGECPLSKLCWNGSRSPPGPPGSRAAAMAATPVPAASVAAAAAAVAAGSKRAQRRRRVNLDSLGESISLLTAPSPQTIHMTLKRTLQYYEHQVIGYRDAEKNFHNISNRCSSADHSNKEEIEDVSGILRCTANVLGLKFQEIQERFGEEFFKICFDENERVLRAVGSTLQDFFNGFDALLEHIRTSFGKQATLESPSFLCKELPEGTLKLHYFHPHHTVGFAMLGMIKAAGKRIYHLNVEVEQIENEKFCSDGSTPSNYSCLTFLIKECETTQITKNIPQGTSQIPTDLRISINTFCRTFPFHLMFDPNMVVLQLGEGLRKQLRCDNHKVLKFEDCFEIVSPKVNATFDRVLLRLSTPFVIRTKPEASGTDNEDKVMEIKGQMIHVPESNAILFLGSPCVDKLDELIGRGLHLSDIPIHDATRDVILVGEQAKAQDGLKKRMDKLKATLEKTHQALEEEKKKTVDLLYSIFPGDVAQQLWQRQQVQARKFDDVTMLFSDIVGFTAICAQCTPMQVISMLNELYTRFDHQCGFLDIYKVETIGDAYCVASGLHRKSLCHAKPIALMALKMMELSEEVLTPDGRPIQMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGSHPRRINISPTTYQLLKREDSFTFIPRSREELPDNFPKEIPGVCYFLELRTGPKPPKPSLSSSRIKKVSYNIGTMFLRETSL
uniprot
proteins
ec_number
4.6.1.2
uniprot
proteins
function
FUNCTION: Alpha subunit of soluble guanylate cyclase (sGC), a central enzyme in nitric oxide (NO) signaling. Functions as the main intracellular receptor for NO. Upon NO binding, catalyzes the conversion of GTP to cyclic GMP (cGMP) and thereby transducing NO signal into a ubiquitous intracellular second messenger. {ECO:0000305|PubMed:11121588}.
uniprot
proteins
mass_dalton
81787
uniprot
proteins
protein_family
Adenylyl cyclase class-4/guanylyl cyclase family
uniprot
proteins
pubmed
11121588
uniprot
proteins
sequence_length
730
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P33402}.
uniprot
proteins