LSM8
entrez
51691
canonical
uniprot
O95777
canonical
ensembl
ENSG00000128534
resolver
ensp
ENSP00000249299
resolver
enst
ENST00000249299
resolver
genesymbol
LSM8
resolver
hgnc
HGNC:20471
resolver
uniprot
A4D0W0
resolver
uniprot_entry
A4D0W0_HUMAN
resolver
uniprot_entry
LSM8_HUMAN
resolver
amino_acid_sequence
MTSALENYINRTVAVITSDGRMIVGTLKGFDQTINLILDESHERVFSSSQGVEQVVLGLYIVRGDNVAVIGEIDEETDSALDLGNIRAEPLNSVAH
uniprot
proteins
function
FUNCTION: Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:28781166}.
uniprot
proteins
mass_dalton
10403
uniprot
proteins
protein_family
SnRNP Sm proteins family
uniprot
proteins
pubmed
10523320
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26912367
uniprot
proteins
pubmed
28781166
uniprot
proteins
sequence_length
96
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10523320, ECO:0000269|PubMed:26912367, ECO:0000269|PubMed:28781166}.
uniprot
proteins