Kansl2
entrez
300206
canonical
uniprot
Q6AY70
canonical
ensembl
ENSRNOG00000060185
resolver
ensembl
ENSRNOG00055025557
resolver
ensembl
ENSRNOG00060006741
resolver
ensembl
ENSRNOG00065023885
resolver
ensp
ENSRNOP00000073779
resolver
genesymbol
Kansl2
resolver
genesymbol_syn
Nsl2
resolver
uniprot
G3V7H0
resolver
uniprot_entry
KANL2_RAT
resolver
uniprot_sec
G3V7H0
resolver
amino_acid_sequence
MNRIRIHVLPTNRGRITPVPRSQEPLSCSFTHRPCSQPRLEGQEFCLKHILEDKNAPFKQCSYISTKNGKRCPSAAPKPEKKDGVSFCAEHARRNALALHAQMKKSNPGPMGETLLCQLSSYAKTELGSQTPESSRSEASRILDEDSWSDGDQEPITVDQTWRGDPDSEADSIDSDQEDPLKHAGVYTAEEVALIMREKLIRLQSLYIDQFKRLQHLLKEKKRRYLHNRKVEHEALGSSLLTGPEGLLAKERENLKRLKCLRRYRQRYGVEALLHRQLKERRMLATEGAAQQAHTTRSSQRCLAFVDDVRCSNQSLPMTRHCLTHICQDTNQVLFKCCQGSEEVPCNKPVPVSLSEDPCCPLHFQLPPQMYKPEQVLSVPDGLEAGPMDLYLSAAELQPTESLPLELSDDLDVVGDGMPCPPSPLLFDPSLTLEDHSVTEIAGGPGQIQVAGDGCRSQGPHNVEKTCAPFPQRGLATANGKPEPTSIS
uniprot
proteins
function
FUNCTION: Non-catalytic component of the NSL histone acetyltransferase complex, a multiprotein complex that mediates histone H4 acetylation at 'Lys-5'- and 'Lys-8' (H4K5ac and H4K8ac) at transcription start sites and promotes transcription initiation. Required for NSL complex stability and for transcription of intraciliary transport genes in both ciliated and non-ciliated cells by regulating histone H4 acetylation at 'Lys-5'- and 'Lys-12' (H4K5ac and H4K12ac). This is necessary for cilium assembly in ciliated cells and for organization of the microtubule cytoskeleton in non-ciliated cells. Required within the NSL complex to maintain nuclear architecture stability by promoting KAT8-mediated acetylation of lamin LMNA. {ECO:0000250|UniProtKB:Q8BQR4, ECO:0000250|UniProtKB:Q9H9L4}.
uniprot
proteins
mass_dalton
54378
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
488
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H9L4}. Mitochondrion {ECO:0000250|UniProtKB:Q8BQR4}.
uniprot
proteins