Rnasel
entrez
24014
canonical
uniprot
Q05921
canonical
ensembl
ENSMUSG00000066800
resolver
ensp
ENSMUSP00000083385
resolver
ensp
ENSMUSP00000138752
resolver
ensp
ENSMUSP00000161801
resolver
enst
ENSMUST00000086209
resolver
genesymbol
Rnasel
resolver
genesymbol_syn
Rns4
resolver
uniprot
B2RQP1
resolver
uniprot
Q9ERU7
resolver
uniprot_entry
B2RQP1_MOUSE
resolver
uniprot_entry
RN5A_MOUSE
resolver
uniprot_sec
Q9ERU7
resolver
activity_regulation
ACTIVITY REGULATION: After binding to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) the homodimerization and subsequent activation occurs. Inhibited by RNASEL inhibitor ABCE1/RLI, a cytoplasmic member of the ATP-binding cassette (ABC) transporter family (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
METPDYNTPQGGTPSAGSQRTVVEDDSSLIKAVQKGDVVRVQQLLEKGADANACEDTWGWTPLHNAVQAGRVDIVNLLLSHGADPHRRKKNGATPFIIAGIQGDVKLLEILLSCGADVNECDENGFTAFMEAAERGNAEALRFLFAKGANVNLRRQTTKDKRRLKQGGATALMSAAEKGHLEVLRILLNDMKAEVDARDNMGRNALIRTLLNWDCENVEEITSILIQHGADVNVRGERGKTPLIAAVERKHTGLVQMLLSREGINIDARDNEGKTALLIAVDKQLKEIVQLLLEKGADKCDDLVWIARRNHDYHLVKLLLPYVANPDTDPPAGDWSPHSSRWGTALKSLHSMTRPMIGKLKIFIHDDYKIAGTSEGAVYLGIYDNREVAVKVFRENSPRGCKEVSCLRDCGDHSNLVAFYGREDDKGCLYVCVSLCEWTLEEFLRLPREEPVENGEDKFAHSILLSIFEGVQKLHLHGYSHQDLQPQNILIDSKKAVRLADFDQSIRWMGESQMVRRDLEDLGRLVLYVVMKGEIPFETLKTQNDEVLLTMSPDEETKDLIHCLFSPGENVKNCLVDLLGHPFFWTWENRYRTLRNVGNESDIKVRKCKSDLLRLLQHQTLEPPRSFDQWTSKIDKNVMDEMNHFYEKRKKNPYQDTVGDLLKFIRNIGEHINEEKKRGMKEILGDPSRYFQETFPDLVIYIYKKLKETEYRKHFPQPPPRLSVPEAVGPGGIQS
uniprot
proteins
ec_number
3.1.26.-
uniprot
proteins
function
FUNCTION: Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis. Might play a central role in the regulation of mRNA turnover (By similarity). Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length (By similarity). Involved in intercellular immune signaling. Cross-activated by 2',5'-oligoadenylates (2-5A) previously generated in RNA virus-infected cells, triggers type I interferon signaling in uninfected neighboring cells to limit local spread of infection. {ECO:0000250|UniProtKB:Q05823, ECO:0000269|PubMed:11585831}.
uniprot
proteins
mass_dalton
83275
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11063255
uniprot
proteins
pubmed
11585831
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23825954
uniprot
proteins
pubmed
29652922
uniprot
proteins
pubmed
7680958
uniprot
proteins
sequence_length
735
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11585831}. Mitochondrion {ECO:0000269|PubMed:11585831}.
uniprot
proteins