Tars3
entrez
272396
canonical
uniprot
Q8BLY2
canonical
ensembl
ENSMUSG00000030515
resolver
ensp
ENSMUSP00000032728
resolver
enst
ENSMUST00000032728
resolver
genesymbol
Tars3
resolver
genesymbol_syn
Tarsl2
resolver
uniprot
Q8CHT2
resolver
uniprot_entry
SYTC2_MOUSE
resolver
uniprot_sec
Q8CHT2
resolver
amino_acid_sequence
MAAQALAAQAVASRLQRQEEDIRWLCAEVQRLRDEQLRGPERGQAEGPRLTREVAQLQAENRDLHQRLCGLRLRLAEQRRTEAGRAAAHEPPTQNQEKDTKKKRLKQSEPGREVKQPNFIKERLQLFETLKTDHQLLPATQEKKNTNNVISVRVAGGKTVQGERWKTTPYQVAAGISKELAEHTVIAKVNGVLWDLDRPLEGDSTVELLMFDNEEAQAVYWHSSAHILGEAMELYYGGHLCYGPPIENGFYYDMFIEDRVVSSTELSALENICKTIIKEKQPFERLEVSKDTLLEMFKYNKFKCRILKEKVDTPTTTVYRCGPLIDLCKGPHVRHTGKIKAIKIFKNSSTYWEGNPEMETLQRIYGISFPDSKMMKDWEKFQEEAKSRDHRKIGKEQELFFFHDLSPGSCFFLPRGAFIYNALMDFIREEYHKRNFTEVLSPNMYNSKLWETSGHWQHYSNNMFTFDVEKDTFALKPMNCPGHCLMFAHRPRSWREMPVRFADFGVLHRNELSGTLSGLTRVRRFQQDDAHIFCMVEQIEEEIKGCLHFLQSVYSTFGFSFQLNLSTRPEHFLGEIEIWDEAERQLQNSLVEFGKPWKINPGDGAFYGPKIDIKIKDAIGRYHQCATIQLDFQLPIRFNLTYVSKDGDDKNRPVIIHRAILGSVERMIAILSENYGGKWPLWLSPRQVMVIPVGPACENYALQVSKECFEEGFMADVDLDDSCTLNKKIRNAQLAQYNFILVVGEKEKINNAVNVRTRDNKIHGEISIASVIEKLKNLKKSRTLNAEEDF
uniprot
proteins
ec_number
6.1.1.3
uniprot
proteins
function
FUNCTION: Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage. {ECO:0000269|PubMed:29579307}.
uniprot
proteins
mass_dalton
91318
uniprot
proteins
mutagenesis
MUTAGEN 222; /note="H->A: Impairs post-transfer editing activity but no effect on aminoacylation activity; when associated with A-226."; /evidence="ECO:0000269|PubMed:29579307"; MUTAGEN 226; /note="H->A: Impairs post-transfer editing activity but no effect on aminoacylation activity; when associated with A-222."; /evidence="ECO:0000269|PubMed:29579307"; MUTAGEN 480; /note="C->A: Impairs aminoacylation activity."; /evidence="ECO:0000269|PubMed:29579307"; MUTAGEN 509; /note="R->A: Impairs aminoacylation activity."; /evidence="ECO:0000269|PubMed:29579307"; MUTAGEN 774..780; /note="KLKNLKK->ALANLAA: Abolishes nuclear localization."; /evidence="ECO:0000269|PubMed:29579307
uniprot
proteins
protein_family
Class-II aminoacyl-tRNA synthetase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29579307
uniprot
proteins
sequence_length
790
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:29579307}. Nucleus {ECO:0000269|PubMed:29579307}. Note=Primarily cytoplasmic. Also detected at lower levels in the nucleus. {ECO:0000269|PubMed:29579307}.
uniprot
proteins