GBP2
entrez
2634
canonical
uniprot
P32456
canonical
ensembl
ENSG00000162645
resolver
ensp
ENSP00000359497
resolver
ensp
ENSP00000434282
resolver
ensp
ENSP00000545631
resolver
ensp
ENSP00000545632
resolver
enst
ENST00000370466
resolver
enst
ENST00000464839
resolver
enst
ENST00000875572
resolver
enst
ENST00000875573
resolver
genesymbol
GBP2
resolver
hgnc
HGNC:4183
resolver
uniprot
Q6GPH0
resolver
uniprot
Q6IAU2
resolver
uniprot
Q86TB0
resolver
uniprot
Q8TCE5
resolver
uniprot_entry
GBP2_HUMAN
resolver
uniprot_entry
Q8TCE5_HUMAN
resolver
uniprot_sec
Q6GPH0
resolver
uniprot_sec
Q6IAU2
resolver
uniprot_sec
Q86TB0
resolver
amino_acid_sequence
MAPEINLPGPMSLIDNTKGQLVVNPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKKNGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDIEKGDNENDSWIFALAILLSSTFVYNSMGTINQQAMDQLHYVTELTDRIKANSSPGNNSVDDSADFVSFFPAFVWTLRDFTLELEVDGEPITADDYLELSLKLRKGTDKKSKSFNDPRLCIRKFFPKRKCFVFDWPAPKKYLAHLEQLKEEELNPDFIEQVAEFCSYILSHSNVKTLSGGIPVNGPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVEKAIAHYEQQMGQKVQLPTETLQELLDLHRDSEREAIEVFMKNSFKDVDQMFQRKLGAQLEARRDDFCKQNSKASSDCCMALLQDIFGPLEEDVKQGTFSKPGGYRLFTQKLQELKNKYYQVPRKGIQAKEVLKKYLESKEDVADALLQTDQSLSEKEKAIEVERIKAESAEAAKKMLEEIQKKNEEMMEQKEKSYQEHVKQLTEKMERDRAQLMAEQEKTLALKLQEQERLLKEGFENESKRLQKDIWDIQMRSKSLEPICNIL
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed:31091448). Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (PubMed:8706832). Following infection, recruited to the pathogen-containing vacuoles or vacuole-escaped bacteria and acts as a positive regulator of inflammasome assembly by promoting the release of inflammasome ligands from bacteria (By similarity). Acts by promoting lysis of pathogen-containing vacuoles, releasing pathogens into the cytosol (By similarity). Following pathogen release in the cytosol, promotes recruitment of proteins that mediate bacterial cytolysis: this liberates ligands that are detected by inflammasomes, such as lipopolysaccharide (LPS) that activates the non-canonical CASP4/CASP11 inflammasome or double-stranded DNA (dsDNA) that activates the AIM2 inflammasome (By similarity). Confers protection to the protozoan pathogen Toxoplasma gondii (By similarity). Independently of its GTPase activity, acts as an inhibitor of various viruses infectivity, such as HIV-1, Zika and influenza A viruses, by inhibiting FURIN-mediated maturation of viral envelope proteins (PubMed:31091448). {ECO:0000250|UniProtKB:Q9Z0E6, ECO:0000269|PubMed:31091448, ECO:0000269|PubMed:8706832}.
uniprot
proteins
mass_dalton
67209
uniprot
proteins
mutagenesis
MUTAGEN 588..591; /note="Missing: No effect on subcellular location by confocal microscopy, but loss of membrane-association by subcellular fractionation."; /evidence="ECO:0000269|PubMed:21151871"; MUTAGEN 588; /note="C->A: Loss of isoprenylation and of localization at the Golgi apparatus."; /evidence="ECO:0000269|PubMed:31091448
uniprot
proteins
post_translational_modification
PTM: (Microbial infection) Ubiquitinated by S.flexneri IpaH9.8, leading to its degradation by the proteasome, thereby preventing its ability to promote host defense against bacterial infection. {ECO:0000269|PubMed:29024643, ECO:0000269|PubMed:29144452}.; PTM: Isoprenylation is required for proper subcellular location. {ECO:0000269|PubMed:21151871}.
uniprot
proteins
protein_family
GB1 subfamily
uniprot
proteins
protein_family
GB1/RHD3 GTPase family
uniprot
proteins
protein_family
TRAFAC class dynamin-like GTPase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
1715024
uniprot
proteins
pubmed
17266443
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21151871
uniprot
proteins
pubmed
29024643
uniprot
proteins
pubmed
29144452
uniprot
proteins
pubmed
31091448
uniprot
proteins
pubmed
33876762
uniprot
proteins
pubmed
8706832
uniprot
proteins
sequence_length
591
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9Z0E6}; Lipid-anchor {ECO:0000269|PubMed:21151871}. Golgi apparatus membrane {ECO:0000269|PubMed:21151871, ECO:0000269|PubMed:31091448}; Lipid-anchor {ECO:0000269|PubMed:21151871}. Cytoplasm {ECO:0000269|PubMed:21151871}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:21151871}. Note=GBP2-GBP5 dimers localize to the Golgi apparatus. {ECO:0000269|PubMed:21151871}.
uniprot
proteins