Dppa3
entrez
73708
canonical
uniprot
Q8QZY3
canonical
ensembl
ENSMUSG00000046323
resolver
ensp
ENSMUSP00000062832
resolver
enst
ENSMUST00000049644
resolver
genesymbol
Dppa3
resolver
genesymbol_syn
Cap1p
resolver
genesymbol_syn
Crg1
resolver
genesymbol_syn
Pgc7
resolver
uniprot
F6S6F5
resolver
uniprot_entry
DPPA3_MOUSE
resolver
uniprot_sec
F6S6F5
resolver
amino_acid_sequence
MEEPSEKVDPMKDPETPQKKDEEDALDDTDVLQPETLVKVMKKLTLNPGVKRSARRRSLRNRIAAVPVENKSEKIRREVQSAFPKRRVRTLLSVLKDPIAKMRRLVRIEQRQKRLEGNEFERDSEPFRCLCTFCHYQRWDPSENAKIGKN
uniprot
proteins
function
FUNCTION: Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis. {ECO:0000269|PubMed:12124616, ECO:0000269|PubMed:12620990, ECO:0000269|PubMed:14654002, ECO:0000269|PubMed:17143267, ECO:0000269|PubMed:21407207, ECO:0000269|PubMed:22034526, ECO:0000269|PubMed:22722204}.
uniprot
proteins
mass_dalton
17670
uniprot
proteins
mutagenesis
MUTAGEN 44; /note="L->A: Abolishes localization to the nucleus and ability to prevent DNA demethylation; when associated with A-46."; /evidence="ECO:0000269|PubMed:17143267"; MUTAGEN 46; /note="L->A: Abolishes localization to the nucleus and ability to prevent DNA demethylation; when associated with A-44."; /evidence="ECO:0000269|PubMed:17143267
uniprot
proteins
pubmed
11900980
uniprot
proteins
pubmed
12124616
uniprot
proteins
pubmed
12620990
uniprot
proteins
pubmed
14654002
uniprot
proteins
pubmed
14684992
uniprot
proteins
pubmed
15018652
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17143267
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21407207
uniprot
proteins
pubmed
22034526
uniprot
proteins
pubmed
22722204
uniprot
proteins
sequence_length
150
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11900980, ECO:0000269|PubMed:12124616, ECO:0000269|PubMed:17143267, ECO:0000269|PubMed:22722204}. Cytoplasm {ECO:0000269|PubMed:11900980, ECO:0000269|PubMed:12124616, ECO:0000269|PubMed:17143267}. Note=Localized in the cytoplasm at the primary oocyte stage and in oocytes within mono-laminar follicles. Expressed in the nucleus and cytoplasm of oocytes in bi-laminar and Graafian follicles and during the 2-cell and morula stages. In 3.5 dpc blastocysts localization is mainly nuclear. Mainly localizes in the female pronucleus, localization to the male pronucleus in much weaker. {ECO:0000269|PubMed:22722204}.
uniprot
proteins