Tardbp
entrez
230908
canonical
uniprot
Q921F2
canonical
ensembl
ENSMUSG00000041459
resolver
ensp
ENSMUSP00000038113
resolver
ensp
ENSMUSP00000081142
resolver
ensp
ENSMUSP00000093386
resolver
ensp
ENSMUSP00000101324
resolver
ensp
ENSMUSP00000101325
resolver
ensp
ENSMUSP00000101327
resolver
ensp
ENSMUSP00000129342
resolver
ensp
ENSMUSP00000130963
resolver
ensp
ENSMUSP00000139476
resolver
ensp
ENSMUSP00000140364
resolver
enst
ENSMUST00000045180
resolver
enst
ENSMUST00000084125
resolver
enst
ENSMUST00000095719
resolver
enst
ENSMUST00000105699
resolver
enst
ENSMUST00000105700
resolver
enst
ENSMUST00000105702
resolver
enst
ENSMUST00000165113
resolver
enst
ENSMUST00000172073
resolver
enst
ENSMUST00000188134
resolver
enst
ENSMUST00000189048
resolver
genesymbol
Tardbp
resolver
genesymbol_syn
TARDBP
resolver
genesymbol_syn
Tdp43
resolver
uniprot
F7CI97
resolver
uniprot
F7CMC9
resolver
uniprot
F7D711
resolver
uniprot
F8WHX5
resolver
uniprot
Q3U591
resolver
uniprot
Q3V0E7
resolver
uniprot
Q544R5
resolver
uniprot
Q6VYI4
resolver
uniprot
Q6VYI5
resolver
uniprot
Q8BLD4
resolver
uniprot
Q8BUM1
resolver
uniprot
Q8R0B4
resolver
uniprot_entry
F7CI97_MOUSE
resolver
uniprot_entry
F7CMC9_MOUSE
resolver
uniprot_entry
F7D711_MOUSE
resolver
uniprot_entry
F8WHX5_MOUSE
resolver
uniprot_entry
Q544R5_MOUSE
resolver
uniprot_entry
Q6VYI4_MOUSE
resolver
uniprot_entry
Q6VYI5_MOUSE
resolver
uniprot_entry
Q8BLD4_MOUSE
resolver
uniprot_entry
Q8BUM1_MOUSE
resolver
uniprot_entry
Q8R0B4_MOUSE
resolver
uniprot_entry
TADBP_MOUSE
resolver
uniprot_sec
Q3U591
resolver
uniprot_sec
Q3V0E7
resolver
amino_acid_sequence
MSEYIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAPDAGWGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQKTSDLIVLGLPWKTTEQDLKDYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSKQSPDEPLRSRKVFVGRCTEDMTAEELQQFFCQYGEVVDVFIPKPFRAFAFVTFADDKVAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFGNSRGGGAGLGNNQGGNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSGNNQSQGSMQREPNQAFGSGNNSYSGSNSGAPLGWGSASNAGSGSGFNGGFGSSMDSKSSGWGM
uniprot
proteins
function
FUNCTION: RNA-binding protein that is involved in various steps of RNA biogenesis and processing. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU-repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs. In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases. Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts. Also regulates mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening. In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival (By similarity). Also participates in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins (PubMed:30464263). Plays a role in the maintenance of the circadian clock periodicity via stabilization of the CRY1 and CRY2 proteins in a FBXL3-dependent manner (PubMed:27123980). Negatively regulates the expression of CDK6 (By similarity). Regulates the expression of HDAC6, ATG7 and VCP in a PPIA/CYPA-dependent manner (PubMed:25678563). {ECO:0000250|UniProtKB:Q13148, ECO:0000269|PubMed:25678563, ECO:0000269|PubMed:27123980, ECO:0000269|PubMed:30464263}.
uniprot
proteins
mass_dalton
44548
uniprot
proteins
post_translational_modification
PTM: Hyperphosphorylated. {ECO:0000250|UniProtKB:Q13148}.; PTM: Ubiquitinated. {ECO:0000250|UniProtKB:Q13148}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19174564
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22570411
uniprot
proteins
pubmed
23449777
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
25678563
uniprot
proteins
pubmed
27123980
uniprot
proteins
pubmed
28072389
uniprot
proteins
pubmed
30464263
uniprot
proteins
sequence_length
414
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13148}. Cytoplasm {ECO:0000269|PubMed:30464263}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:Q13148}. Mitochondrion {ECO:0000250|UniProtKB:Q13148}. Note=Continuously travels in and out of the nucleus. Localizes to stress granules in response to oxidative stress. A small subset localizes in mitochondria. {ECO:0000250|UniProtKB:Q13148}.
uniprot
proteins