ORC5
entrez
5001
canonical
uniprot
O43913
canonical
ensembl
ENSG00000164815
resolver
ensp
ENSP00000297431
resolver
ensp
ENSP00000395747
resolver
ensp
ENSP00000649278
resolver
ensp
ENSP00000777601
resolver
genesymbol
ORC5
resolver
genesymbol
ORC5L
resolver
genesymbol_syn
ORC5L
resolver
hgnc
HGNC:8491
resolver
uniprot
A4D0P7
resolver
uniprot
A4D0P8
resolver
uniprot
O60590
resolver
uniprot
O95268
resolver
uniprot
Q53FC8
resolver
uniprot_entry
A4D0P7_HUMAN
resolver
uniprot_entry
ORC5_HUMAN
resolver
uniprot_entry
Q53FC8_HUMAN
resolver
uniprot_sec
A4D0P8
resolver
uniprot_sec
O60590
resolver
uniprot_sec
O95268
resolver
amino_acid_sequence
MPHLENVVLCRESQVSILQSLFGERHHFSFPSIFIYGHTASGKTYVTQTLLKTLELPHVFVNCVECFTLRLLLEQILNKLNHLSSSEDGCSTEITCETFNDFVRLFKQVTTAENLKDQTVYIVLDKAEYLRDMEANLLPGFLRLQELADRNVTVLFLSEIVWEKFRPNTGCFEPFVLYFPDYSIGNLQKILSHDHPPEYSADFYAAYINILLGVFYTVCRDLKELRHLAVLNFPKYCEPVVKGEASERDTRKLWRNIEPHLKKAMQTVYLREISSSQWEKLQKDDTDPGQLKGLSAHTHVELPYYSKFILIAAYLASYNPARTDKRFFLKHHGKIKKTNFLKKHEKTSNHLLGPKPFPLDRLLAILYSIVDSRVAPTANIFSQITSLVTLQLLTLVGHDDQLDGPKYKCTVSLDFIRAIARTVNFDIIKYLYDFL
uniprot
proteins
function
FUNCTION: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. {ECO:0000269|PubMed:31160578}.
uniprot
proteins
mass_dalton
50283
uniprot
proteins
post_translational_modification
PTM: Multi-mono-ubiquitinated by OBI1; ubiquitination is important for efficient DNA replication origin site activation. Ubiquitination levels are low in mitotic and early G1-phAse cells and are induced in late G1-/early S-phase, peaking in S-phase and decrease toward the end of the cell cycle. {ECO:0000269|PubMed:31160578}.
uniprot
proteins
protein_family
ORC5 family
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
12909626
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17716973
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
31160578
uniprot
proteins
pubmed
9417919
uniprot
proteins
pubmed
9765232
uniprot
proteins
pubmed
9829972
uniprot
proteins
sequence_length
435
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31160578}. Chromosome {ECO:0000269|PubMed:31160578}.
uniprot
proteins