NFATC2IP
entrez
84901
canonical
uniprot
Q8NCF5
canonical
ensembl
ENSG00000176953
resolver
ensp
ENSP00000324792
resolver
ensp
ENSP00000565691
resolver
ensp
ENSP00000565692
resolver
ensp
ENSP00000657537
resolver
genesymbol
NFATC2IP
resolver
genesymbol_syn
NIP45
resolver
hgnc
HGNC:25906
resolver
uniprot
B7Z4G5
resolver
uniprot
Q66K34
resolver
uniprot
Q6NVK1
resolver
uniprot
Q8NFR2
resolver
uniprot
Q96ST9
resolver
uniprot_entry
NF2IP_HUMAN
resolver
uniprot_sec
B7Z4G5
resolver
uniprot_sec
Q66K34
resolver
uniprot_sec
Q6NVK1
resolver
uniprot_sec
Q8NFR2
resolver
uniprot_sec
Q96ST9
resolver
amino_acid_sequence
MAEPVGKRGRWSGGSGAGRGGRGGWGGRGRRPRAQRSPSRGTLDVVSVDLVTDSDEEILEVATARGAADEVEVEPPEPPGPVASRDNSNSDSEGEDRRPAGPPREPVRRRRRLVLDPGEAPLVPVYSGKVKSSLRLIPDDLSLLKLYPPGDEEEAELADSSGLYHEGSPSPGSPWKTKLRTKDKEEKKKTEFLDLDNSPLSPPSPRTKSRTHTRALKKLSEVNKRLQDLRSCLSPKPPQGQEQQGQEDEVVLVEGPTLPETPRLFPLKIRCRADLVRLPLRMSEPLQSVVDHMATHLGVSPSRILLLFGETELSPTATPRTLKLGVADIIDCVVLTSSPEATETSQQLQLRVQGKEKHQTLEVSLSRDSPLKTLMSHYEEAMGLSGRKLSFFFDGTKLSGRELPADLGMESGDLIEVWG
uniprot
proteins
function
FUNCTION: In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
45817
uniprot
proteins
post_translational_modification
PTM: Methylation at the N-terminus by PRMT1 modulates interaction with the NFAT complex and results in augmented cytokine production. {ECO:0000250}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
419
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=TRAF1 is associated with a fraction of NFATC2IP in the cytoplasm and prevents its translocation to the nucleus. {ECO:0000250}.
uniprot
proteins