Fbxl2
entrez
72179
canonical
uniprot
Q8BH16
canonical
ensembl
ENSMUSG00000032507
resolver
ensp
ENSMUSP00000035090
resolver
ensp
ENSMUSP00000114075
resolver
ensp
ENSMUSP00000219551
resolver
ensp
ENSMUSP00000219566
resolver
enst
ENSMUST00000035090
resolver
enst
ENSMUST00000117537
resolver
genesymbol
Fbxl2
resolver
uniprot
Q4VA21
resolver
uniprot
Q8BXM4
resolver
uniprot_entry
FBXL2_MOUSE
resolver
uniprot_entry
Q4VA21_MOUSE
resolver
uniprot_sec
Q8BXM4
resolver
amino_acid_sequence
MVFSNSDDGLINKKLPKELLLRIFSFLDIVTLCRCAQISKAWNILALDGSNWQRVDLFNFQTDVEGRVVENISKRCGGFLRKLSLRGCIGVGDSSLKTFAQNCRNIEHLNLNGCTKITDSTCYSLSRFCSKLKHLDLTSCVSVTNSSLKGISEGCRNLEYLNLSWCDQITKEGIEALVRGCRGLKALLLRGCTQLEDEALKHIQNHCHELVSLNLQSCSRITDDGVVQICRGCHRLQALCLSGCSNLTDASLTALGLNCPRLQVLEAARCSHLTDAGFTLLARNCHELEKMDLEECVLITDSTLVQLSIHCPKLQALSLSHCELITDEGILHLSSSTCGHERLRVLELDNCLLVTDASLEHLENCRGLERLELYDCQQVTRAGIKRMRAQLPHVKVHAYFAPVTPPPAVAGSGHRLCRCCVIL
uniprot
proteins
function
FUNCTION: Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:21343341, PubMed:23542741). Unlike many F-box proteins, FBXL2 does not seem to target phosphodegron within its substrates but rather calmodulin-binding motifs and is thereby antagonized by calmodulin (By similarity). This is the case for the cyclins CCND2 and CCND3 which polyubiquitination and subsequent degradation are inhibited by calmodulin (By similarity). Through CCND2 and CCND3 degradation induces cell-cycle arrest in G(0) (By similarity). SCF(FBXL2) also mediates PIK3R2 ubiquitination and proteasomal degradation thereby regulating phosphatidylinositol 3-kinase signaling and autophagy (By similarity). PCYT1A monoubiquitination by SCF(FBXL2) and subsequent degradation regulates synthesis of phosphatidylcholine, which is utilized for formation of membranes and of pulmonary surfactant (PubMed:21343341). The SCF(FBXL2) complex acts as a regulator of inflammation by mediating ubiquitination and degradation of TRAF proteins (TRAF1, TRAF2, TRAF3, TRAF4, TRAF5 and TRAF6) (PubMed:23542741). The SCF(FBXL2) complex acts as a negative regulator of the NLRP3 inflammasome by mediating ubiquitination and degradation of NLRP3 (By similarity). The GGTase-3 complex, composed of PTAR1 and RABGGTB, geranylgeranylates and targets FBXL2 to the cellular membranes, where FBXL2 forms part of the SCF(FBXL2) complex that mediates the degradation of membrane-anchored proteins (By similarity). {ECO:0000250|UniProtKB:Q9UKC9, ECO:0000269|PubMed:21343341, ECO:0000269|PubMed:23542741}.
uniprot
proteins
mass_dalton
46890
uniprot
proteins
mutagenesis
MUTAGEN 404; /note="T->A: Abolished phosphorylation by GSK3B, preventing ubiquitination by the SCF(FBXO3) complex."; /evidence="ECO:0000269|PubMed:23542741
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:23542741}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by GSK-beta (GSK3B), promoting recognition by FBXO3, leading to its ubiquitination by the SCF(FBXO3) complex. {ECO:0000269|PubMed:23542741}.; PTM: Ubiquitinated at Lys-201 by the SCF(FBXO3) complex in response to lipopolysaccharide (LPS), leading to its degradation by the proteasome. {ECO:0000269|PubMed:23542741}.; PTM: Geranylgeranylation at Cys-420 is mediated by the GGTase-3 complex and is required for its association with cell membranes and the recruitment of substrates to the active SCF(FBXL2) complex. {ECO:0000250|UniProtKB:Q9UKC9}.
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21343341
uniprot
proteins
pubmed
23542741
uniprot
proteins
sequence_length
423
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9UKC9}; Lipid-anchor {ECO:0000250|UniProtKB:Q9UKC9}.
uniprot
proteins