Cox8b
entrez
25250
canonical
uniprot
P16221
canonical
ensembl
ENSRNOG00000073367
resolver
ensembl
ENSRNOG00055028816
resolver
ensembl
ENSRNOG00060027633
resolver
ensembl
ENSRNOG00065018789
resolver
ensp
ENSRNOP00000110264
resolver
ensp
ENSRNOP00055041105
resolver
ensp
ENSRNOP00060039890
resolver
ensp
ENSRNOP00065025154
resolver
enst
ENSRNOT00000171100
resolver
enst
ENSRNOT00055049907
resolver
enst
ENSRNOT00060047946
resolver
enst
ENSRNOT00065031558
resolver
genesymbol
Cox8b
resolver
genesymbol_syn
Cox8h
resolver
uniprot_entry
COX8B_RAT
resolver
amino_acid_sequence
MPRLPPILRLLQAPEKYTVIPKARISSKPAKSPTSAMDQAVGMSVIIAGFMVPAGWVLSHLESYKRSSAA
uniprot
proteins
function
FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P10175}.
uniprot
proteins
mass_dalton
7549
uniprot
proteins
pathway_participation
PATHWAY: Energy metabolism; oxidative phosphorylation. {ECO:0000250|UniProtKB:P10175}.
uniprot
proteins
protein_family
Cytochrome c oxidase VIII family
uniprot
proteins
pubmed
1324738
uniprot
proteins
pubmed
2153407
uniprot
proteins
pubmed
7601105
uniprot
proteins
pubmed
8939982
uniprot
proteins
sequence_length
70
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P10175}; Single-pass membrane protein {ECO:0000250|UniProtKB:P10175}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..59; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P10175
uniprot
proteins