Glp1r
entrez
14652
canonical
uniprot
O35659
canonical
ensembl
ENSMUSG00000024027
resolver
ensp
ENSMUSP00000110221
resolver
ensp
ENSMUSP00000157572
resolver
enst
ENSMUST00000114574
resolver
enst
ENSMUST00000236038
resolver
genesymbol
Glp1r
resolver
uniprot
Q1JQR8
resolver
uniprot_entry
GLP1R_MOUSE
resolver
uniprot_sec
Q1JQR8
resolver
amino_acid_sequence
MASTPSLLRLALLLLGAVGRAGPRPQGTTVSLSETVQKWREYRRQCQRFLTEAPLLATGLFCNRTFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVYRFCTAEGLWLHKDNSSLPWRDLSECEESKRGERNFPEEQLLSLYIIYTVGYALSFSALVIASAILVGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLGCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVFSEQRIFKLYLSIGWGVPLLFVIPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFIRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQMEFRKCWERWRLEHLNIQRDCSMKPLKCPTSSVSSGATVGSSVYAATCQSSYS
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:9568699). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (By similarity). Plays a role in regulating insulin secretion in response to GLP-1 (PubMed:9568699). {ECO:0000250|UniProtKB:P43220, ECO:0000269|PubMed:9568699}.
uniprot
proteins
mass_dalton
53028
uniprot
proteins
post_translational_modification
PTM: N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER. {ECO:0000250|UniProtKB:P43220}.
uniprot
proteins
protein_family
G protein-coupled receptor 2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16946080
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
9568699
uniprot
proteins
sequence_length
463
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:9568699}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P43220}.
uniprot
proteins
transmembrane_region
TRANSMEM 140..164; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P43220"; TRANSMEM 176..201; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P43220"; TRANSMEM 228..251; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P43220"; TRANSMEM 266..290; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P43220"; TRANSMEM 306..328; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P43220"; TRANSMEM 349..370; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P43220"; TRANSMEM 384..404; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P43220
uniprot
proteins