Jam3
entrez
83964
canonical
uniprot
Q9D8B7
canonical
ensembl
ENSMUSG00000031990
resolver
ensp
ENSMUSP00000034472
resolver
ensp
ENSMUSP00000319616
resolver
enst
ENSMUST00000034472
resolver
genesymbol
Jam3
resolver
uniprot
Q8BT59
resolver
uniprot
Q9D1M9
resolver
uniprot
Q9EPK4
resolver
uniprot_entry
JAM3_MOUSE
resolver
uniprot_sec
Q8BT59
resolver
uniprot_sec
Q9D1M9
resolver
uniprot_sec
Q9EPK4
resolver
amino_acid_sequence
MALSRRLRLRLYARLPDFFLLLLFRGCMIEAVNLKSSNRNPVVHEFESVELSCIITDSQTSDPRIEWKKIQDGQTTYVYFDNKIQGDLAGRTDVFGKTSLRIWNVTRSDSAIYRCEVVALNDRKEVDEITIELIVQVKPVTPVCRIPAAVPVGKTATLQCQESEGYPRPHYSWYRNDVPLPTDSRANPRFQNSSFHVNSETGTLVFNAVHKDDSGQYYCIASNDAGAARCEGQDMEVYDLNIAGIIGGVLVVLIVLAVITMGICCAYRRGCFISSKQDGESYKSPGKHDGVNYIRTSEEGDFRHKSSFVI
uniprot
proteins
function
FUNCTION: Junctional adhesion protein that mediates heterotypic cell-cell interactions with its cognate receptor JAM2 to regulate different cellular processes (PubMed:15372036, PubMed:16093349). Plays a role in homing and mobilization of hematopoietic stem and progenitor cells within the bone marrow. At the surface of bone marrow stromal cells, it contributes to the retention of the hematopoietic stem and progenitor cells expressing JAM3 (PubMed:24357068). Plays a central role in leukocytes extravasation by facilitating transmigration through the endothelium (PubMed:16297198). Plays a role in spermatogenesis where JAM2 and JAM3, which are respectively expressed by Sertoli and germ cells, mediate an interaction between both cell types and play an essential role in the anchorage of germ cells onto Sertoli cells and the assembly of cell polarity complexes during spermatid differentiation (PubMed:15372036, PubMed:15994945). Also functions as a counter-receptor for ITGAM, mediating leukocyte-platelet interactions and is involved in the regulation of transepithelial migration of polymorphonuclear neutrophils (PMN) (PubMed:16093349). Plays a role in angiogenesis (PubMed:15994945). Plays a role in the regulation of cell migration (By similarity). During myogenesis, it is involved in myocyte fusion (By similarity). {ECO:0000250|UniProtKB:A3KPA0, ECO:0000250|UniProtKB:Q9BX67, ECO:0000269|PubMed:15372036, ECO:0000269|PubMed:15994945, ECO:0000269|PubMed:16093349, ECO:0000269|PubMed:16297198, ECO:0000269|PubMed:24357068}.; FUNCTION: [Soluble form of JAM-C]: Promotes chemotaxis of vascular endothelial cells and stimulates angiogenesis. {ECO:0000269|PubMed:20592283}.
uniprot
proteins
mass_dalton
34838
uniprot
proteins
mutagenesis
MUTAGEN 66; /note="E->R: Decreased binding to JAM2."; /evidence="ECO:0000269|PubMed:16093349
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved from endothelial cells surface into a soluble form by ADAM10 and ADAM17; the release of soluble JAM3 is increased by pro-inflammatory factors. {ECO:0000250|UniProtKB:Q9BX67}.; PTM: N-glycosylated. {ECO:0000269|PubMed:11053409}.; PTM: S-palmitoylated by ZDHHC7. S-palmitoylation promotes expression at tight junctions. {ECO:0000250|UniProtKB:Q9BX67}.
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
11036763
uniprot
proteins
pubmed
11053409
uniprot
proteins
pubmed
11739175
uniprot
proteins
pubmed
12810109
uniprot
proteins
pubmed
15372036
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15994945
uniprot
proteins
pubmed
16093349
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16297198
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
20592283
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24357068
uniprot
proteins
pubmed
28617811
uniprot
proteins
sequence_length
310
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11053409, ECO:0000269|PubMed:11739175, ECO:0000269|PubMed:16093349}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q9BX67}. Cell junction {ECO:0000269|PubMed:11053409, ECO:0000269|PubMed:16093349}. Cell junction, desmosome {ECO:0000250|UniProtKB:Q9BX67}. Cell junction, tight junction {ECO:0000269|PubMed:11053409, ECO:0000269|PubMed:11739175}. Note=Detected in the acrosome region in developing spermatids (PubMed:28617811). In epithelial cells, it is expressed at desmosomes but not at tight junctions (By similarity). Localizes at the cell surface of endothelial cells; treatment of endothelial cells with vascular endothelial growth factor stimulates recruitment of JAM3 to cell-cell contacts (By similarity). {ECO:0000250|UniProtKB:Q9BX67, ECO:0000269|PubMed:28617811}.; SUBCELLULAR LOCATION: [Soluble form of JAM-C]: Secreted {ECO:0000250|UniProtKB:Q9BX67}.
uniprot
proteins
transmembrane_region
TRANSMEM 242..262; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins