Cip2a
entrez
224171
canonical
uniprot
Q8BWY9
canonical
ensembl
ENSMUSG00000033031
resolver
ensp
ENSMUSP00000044714
resolver
enst
ENSMUST00000048374
resolver
genesymbol
Cip2a
resolver
genesymbol_syn
Kiaa1524
resolver
uniprot
B2RQ25
resolver
uniprot
Q69ZH6
resolver
uniprot
Q7TPZ7
resolver
uniprot_entry
CIP2A_MOUSE
resolver
uniprot_sec
B2RQ25
resolver
uniprot_sec
Q69ZH6
resolver
uniprot_sec
Q7TPZ7
resolver
amino_acid_sequence
MDSTACLKSLLLSISQYKAVKSEANATQLLRHLEVVSGQKLTRLFTSHQILPSECLSCLVELLEDPNISASLILSIISLLSQLAIDNETRDCLQNIYNLNSVLSGVVCRSSACHNDSVFLQCIQLLQRLTYNAKFFHSGAHIDDLITFLIGHVQSSEDELTMPCLGLLANLCRHNLSVQTQIKTLSNVKSFYRTLISFLAHSSLTVVVFALSILSSLTLNEEVGEKLFHARNIHQTFQLIFNILINGDGTLTRKYSVDLLMDLLKNPKIADYLTRYEHFSSCLSQVLGLLNAKDPDSSSKVLELLLAFCAVTQLRHVLSQMMFEQSPSGNILGSRPKSLEPTAALLRWLSQPLDGAENCSVLALELFKEIFEDVIDTGNCSSTDHFVTLLLPTILDQLQFKEQNLDETLVRNKCERMVKAIEVLLTLCGDDSLKMHVVKILTTLKCTTLIEQQFTYGKIDLGFGTKVADSELCKLAADVILKTLTLMNKLKQLVPGMEVSFYKILQDPRLITPLAFALTSDNREQVQSGLGILLEASPLPDFPAFVLGESIAANNVYRQQETEHLPRKMTFQPLNHGFSTSAKCLTPPPSKDNAPALNIEDLIEKLQAGVMVKDQISDIRISDIMDVYEMKLSTLASKESRLQDLLEAKALALAQADRLIAQYRCQRTQAETEARTLAGMLREVERKNEELSVLLKSQQLESERAQNDIEHLFQHSKKLESVAAEHEILTKSYMELVQRNEATEKKNTDLQTTCESLNKHIETMKKLNEALKQQNEKTIAQLIEKEEQRKEVQSQLADRECKLSNLHKIAKSQEEKLNVLQKEKEDKQETIDILRKELSRTEQIRKELSIKASSLEMHKAQLEGRLEEKESLLKLQQEELNKHSHMIAMIHSLSGGKISPETVNLSI
uniprot
proteins
function
FUNCTION: Acts as an inhibitor of protein phosphatase PP2A (By similarity). Promotes anchorage-independent cell growth and tumor formation by preventing dephosphorylation of MYC, thereby stabilizing MYC in human malignancies (By similarity). Together with TOPBP1, plays an essential role in the response to genome instability generated by the presence of acentric chromosome fragments derived from shattered chromosomes within micronuclei (By similarity). Micronuclei, which are frequently found in cancer cells, consist of chromatin surrounded by their own nuclear membrane: following breakdown of the micronuclear envelope, a process associated with chromothripsis, the CIP2A-TOPBP1 complex tethers chromosome fragments during mitosis to ensure clustered segregation of the fragments to a single daughter cell nucleus, facilitating re-ligation with limited chromosome scattering and loss (By similarity). {ECO:0000250|UniProtKB:Q8TCG1}.
uniprot
proteins
mass_dalton
102043
uniprot
proteins
protein_family
CIP2A family
uniprot
proteins
pubmed
12118381
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22461891
uniprot
proteins
sequence_length
907
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8TCG1}. Chromosome {ECO:0000250|UniProtKB:Q8TCG1}. Note=Predominantly localizes within the cytoplasm. Localizes to broken chromosomes within micronuclei during interphase and following chromothripsis. Localization to broken chromosomes is mainly independent of MDC1. {ECO:0000250|UniProtKB:Q8TCG1}.
uniprot
proteins