Taar9
entrez
503558
canonical
uniprot
Q5QD04
canonical
ensembl
ENSMUSG00000037424
resolver
ensp
ENSMUSP00000043552
resolver
enst
ENSMUST00000041180
resolver
genesymbol
Taar9
resolver
uniprot
B2RT07
resolver
uniprot_entry
TAAR9_MOUSE
resolver
uniprot_sec
B2RT07
resolver
amino_acid_sequence
MTSDFSPEPPMELCYENVNGSCIKSSYAPWPRAILYGVLGLGALLAVFGNLLVIIAILHFKQLHTPTNFLVASLACADFLVGVTVMPFSTVRSVESCWYFGESYCKFHTCFDTSFCFASLFHLCCISIDRYIAVTDPLTYPTKFTVSVSGLCIALSWFFSVTYSFSIFYTGANEEGIEELVVALTCVGGCQAPLNQNWVLLCFLLFFLPTVVMVFLYGRIFLVAKYQARKIEGTANQAQASSESYKERVAKRERKAAKTLGIAMAAFLVSWLPYIIDAVIDAYMNFITPAYVYEILVWCVYYNSAMNPLIYAFFYPWFRKAIKLIVSGKVFRADSSTTNLFSEEAGAG
uniprot
proteins
function
FUNCTION: Olfactory receptor specific for trace amines, such as triethylamine, N,N-dimethylcyclohexylamine (DMCHA), beta-phenylethylamine (beta-PEA), cadaverine (CAD) and polyamines such as spermine and spermidine (PubMed:34600890, PubMed:35177711, PubMed:37225986). Trace amine compounds are enriched in animal body fluids and act on trace amine-associated receptors (TAARs) to elicit both intraspecific and interspecific innate behaviors (PubMed:37225986). Trace amine-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL or GNAS) (PubMed:37225986). In mature olfactory sensory neurons, Taar9 is coupled with GNAL/G(olf)G alpha protein and mediates activation of adenylate cyclase activity to activate cAMP signaling and eventually transmit odorant signals to achieve membrane depolarization (PubMed:37225986). In immature olfactory sensory neurons, Taar9 is coupled with GNAS/G(s) G alpha proteins (PubMed:37225986). {ECO:0000269|PubMed:34600890, ECO:0000269|PubMed:35177711, ECO:0000269|PubMed:37225986}.
uniprot
proteins
mass_dalton
38901
uniprot
proteins
mutagenesis
MUTAGEN 35; /note="L->W: Decreased binding to spermidine."; /evidence="ECO:0000269|PubMed:35177711"; MUTAGEN 109; /note="T->A: Abolished activation of G(s) G alpha protein in response to spermidine-binding."; /evidence="ECO:0000269|PubMed:37225986"; MUTAGEN 112; /note="D->A,N,E: Abolished activation of G(s) G alpha protein in response to trace amine-binding."; /evidence="ECO:0000269|PubMed:34600890, ECO:0000269|PubMed:37225986"; MUTAGEN 113; /note="T->A,I,V,L: Abolished activation of G(s) G alpha protein in response to spermidine-binding."; /evidence="ECO:0000269|PubMed:37225986"; MUTAGEN 117; /note="F->T,L: Abolished activation of G(s) G alpha protein in response to trace amine-binding."; /evidence="ECO:0000269|PubMed:37225986"; MUTAGEN 168; /note="F->V: Abolished activation of G(s) G alpha protein in response to trace amine-binding."; /evidence="ECO:0000269|PubMed:37225986"; MUTAGEN 178..179; /note="EE->AA: Decreased binding to spermidine."; /evidence="ECO:0000269|PubMed:35177711"; MUTAGEN 178; /note="E->A: Does not affect binding to spermidine."; /evidence="ECO:0000269|PubMed:35177711"; MUTAGEN 179; /note="E->A: Does not affect binding to spermidine."; /evidence="ECO:0000269|PubMed:35177711"; MUTAGEN 263; /note="A->I,L: Decreased activation of GNAL/G(olf) G alpha protein in response to trace amine-binding without affecting activation of G(s) G alpha proteins."; /evidence="ECO:0000269|PubMed:37225986"; MUTAGEN 271; /note="W->A: Abolished activation of G(s) G alpha protein in response to trace amine-binding."; /evidence="ECO:0000269|PubMed:37225986"; MUTAGEN 274; /note="Y->C,A,L: Abolished activation of G(s) G alpha protein in response to trace amine-binding."; /evidence="ECO:0000269|PubMed:34600890, ECO:0000269|PubMed:37225986"; MUTAGEN 281; /note="D->E,N: Decreased response following spermidine-binding."; /evidence="ECO:0000269|PubMed:35177711"; MUTAGEN 285; /note="N->W: Decreased binding to spermidine."; /evidence="ECO:0000269|PubMed:35177711"; MUTAGEN 290; /note="A->W: Decreased binding to spermidine."; /evidence="ECO:0000269|PubMed:35177711"; MUTAGEN 293; /note="Y->L: Abolished activation of G(s) G alpha protein in response to trace amine-binding."; /evidence="ECO:0000269|PubMed:37225986"; MUTAGEN 294; /note="E->D,Q,A: Reduced activation in response to spermidine- or spermine-binding."; /evidence="ECO:0000269|PubMed:34600890, ECO:0000269|PubMed:35177711"; MUTAGEN 295; /note="I->W: Decreased binding to spermidine."; /evidence="ECO:0000269|PubMed:35177711"; MUTAGEN 297; /note="V->C,T: Abolished activation of G(s) G alpha protein in response to trace amine-binding."; /evidence="ECO:0000269|PubMed:37225986"; MUTAGEN 298; /note="W->F,Y: Increased activation in response to cadaverine- or spermidine-binding."; /evidence="ECO:0000269|PubMed:34600890"; MUTAGEN 300; /note="V->A,G: Abolished activation of G(s) G alpha protein in response to trace amine-binding."; /evidence="ECO:0000269|PubMed:37225986"; MUTAGEN 300; /note="V->T: Abolished activation in response to cadaverin- or spermidine-binding."; /evidence="ECO:0000269|PubMed:34600890"; MUTAGEN 301; /note="Y->A: Abolished activation of G(s) G alpha protein in response to trace amine-binding."; /evidence="ECO:0000269|PubMed:34600890, ECO:0000269|PubMed:37225986
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15718104
uniprot
proteins
pubmed
16878137
uniprot
proteins
pubmed
23624375
uniprot
proteins
pubmed
34600890
uniprot
proteins
pubmed
35177711
uniprot
proteins
pubmed
37225986
uniprot
proteins
sequence_length
348
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:37225986}; Multi-pass membrane protein {ECO:0000269|PubMed:37225986}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..58; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:37225986, ECO:0007744|PDB:8ITF, ECO:0007744|PDB:8IW1, ECO:0007744|PDB:8IW4, ECO:0007744|PDB:8IW7, ECO:0007744|PDB:8IW9, ECO:0007744|PDB:8IWE, ECO:0007744|PDB:8IWM"; TRANSMEM 69..90; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:37225986, ECO:0007744|PDB:8ITF, ECO:0007744|PDB:8IW1, ECO:0007744|PDB:8IW4, ECO:0007744|PDB:8IW7, ECO:0007744|PDB:8IW9, ECO:0007744|PDB:8IWE, ECO:0007744|PDB:8IWM"; TRANSMEM 106..128; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:37225986, ECO:0007744|PDB:8ITF, ECO:0007744|PDB:8IW1, ECO:0007744|PDB:8IW4, ECO:0007744|PDB:8IW7, ECO:0007744|PDB:8IW9, ECO:0007744|PDB:8IWE, ECO:0007744|PDB:8IWM"; TRANSMEM 149..170; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:37225986, ECO:0007744|PDB:8ITF, ECO:0007744|PDB:8IW1, ECO:0007744|PDB:8IW4, ECO:0007744|PDB:8IW7, ECO:0007744|PDB:8IW9, ECO:0007744|PDB:8IWE, ECO:0007744|PDB:8IWM"; TRANSMEM 197..218; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:37225986, ECO:0007744|PDB:8ITF, ECO:0007744|PDB:8IW1, ECO:0007744|PDB:8IW4, ECO:0007744|PDB:8IW7, ECO:0007744|PDB:8IW9, ECO:0007744|PDB:8IWE, ECO:0007744|PDB:8IWM"; TRANSMEM 257..280; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:37225986, ECO:0007744|PDB:8ITF, ECO:0007744|PDB:8IW1, ECO:0007744|PDB:8IW4, ECO:0007744|PDB:8IW7, ECO:0007744|PDB:8IW9, ECO:0007744|PDB:8IWE, ECO:0007744|PDB:8IWM"; TRANSMEM 294..314; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:37225986, ECO:0007744|PDB:8ITF, ECO:0007744|PDB:8IW1, ECO:0007744|PDB:8IW4, ECO:0007744|PDB:8IW7, ECO:0007744|PDB:8IW9, ECO:0007744|PDB:8IWE, ECO:0007744|PDB:8IWM
uniprot
proteins