PDE5A
entrez
8654
canonical
uniprot
O76074
canonical
ensembl
ENSG00000138735
resolver
ensp
ENSP00000264805
resolver
ensp
ENSP00000347046
resolver
ensp
ENSP00000377957
resolver
ensp
ENSP00000777589
resolver
enst
ENST00000394439
resolver
genesymbol
PDE5A
resolver
genesymbol_syn
PDE5
resolver
hgnc
HGNC:8784
resolver
uniprot
A0AV69
resolver
uniprot
A8K2C4
resolver
uniprot
G5E9C5
resolver
uniprot
O75026
resolver
uniprot
O75887
resolver
uniprot
Q86UI0
resolver
uniprot
Q86V66
resolver
uniprot
Q9Y6Z6
resolver
uniprot_entry
G5E9C5_HUMAN
resolver
uniprot_entry
PDE5A_HUMAN
resolver
uniprot_sec
A0AV69
resolver
uniprot_sec
A8K2C4
resolver
uniprot_sec
O75026
resolver
uniprot_sec
O75887
resolver
uniprot_sec
Q86UI0
resolver
uniprot_sec
Q86V66
resolver
uniprot_sec
Q9Y6Z6
resolver
activity_regulation
ACTIVITY REGULATION: Sildenafil (Viagra) is a highly selective and potent inhibitor of PDE5A and is effective in the treatment of penile erectile dysfunction. Also inhibited by zaprinast. {ECO:0000269|PubMed:12955149}.
uniprot
proteins
amino_acid_sequence
MERAGPSFGQQRQQQQPQQQKQQQRDQDSVEAWLDDHWDFTFSYFVRKATREMVNAWFAERVHTIPVCKEGIRGHTESCSCPLQQSPRADNSAPGTPTRKISASEFDRPLRPIVVKDSEGTVSFLSDSEKKEQMPLTPPRFDHDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLFLVCEDSSNDKFLISRLFDVAEGSTLEEVSNNCIRLEWNKGIVGHVAALGEPLNIKDAYEDPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGIVLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCSDSFSSVFHMECEELEKSSDTLTREHDANKINYMYAQYVKNTMEPLNIPDVSKDKRFPWTTENTGNVNQQCIRSLLCTPIKNGKKNKVIGVCQLVNKMEENTGKVKPFNRNDEQFLEAFVIFCGLGIQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQSLAAAVVPSAQTLKITDFSFSDFELSDLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAGKIQNKLTDLEILALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSIMEHHHFDQCLMILNSPGNQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRKNQFNLEDPHQKELFLAMLMTACDLSAITKPWPIQQRIAELVATEFFDQGDRERKELNIEPTDLMNREKKNKIPSMQVGFIDAICLQLYEALTHVSEDCFPLLDGCRKNRQKWQALAEQQEKMLINGESGQAKRN
uniprot
proteins
ec_number
3.1.4.35
uniprot
proteins
function
FUNCTION: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:15489334, PubMed:9714779). Specifically regulates nitric-oxide-generated cGMP (PubMed:15489334). {ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:9714779}.
uniprot
proteins
mass_dalton
99985
uniprot
proteins
mutagenesis
MUTAGEN 767; /note="A->N: Changes substrate selectivity from cGMP-specific to dual cAMP and cGMP binding and hydrolysis; when associated with Y-775 and Y-853."; /evidence="ECO:0000269|PubMed:15260978"; MUTAGEN 775; /note="Q->Y: Changes substrate selectivity from cGMP-specific to dual cAMP and cGMP binding and hydrolysis; when associated with N-767 and Y-853."; /evidence="ECO:0000269|PubMed:15260978"; MUTAGEN 853; /note="W->Y: Changes substrate selectivity from cGMP-specific to dual cAMP and cGMP binding and hydrolysis; when associated with N-767 and Y-775."; /evidence="ECO:0000269|PubMed:15260978
uniprot
proteins
pathway_participation
PATHWAY: Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1.
uniprot
proteins
post_translational_modification
PTM: Phosphorylation is regulated by binding of cGMP to the two allosteric sites (By similarity). Phosphorylation by PRKG1 leads to its activation. {ECO:0000250, ECO:0000269|PubMed:11723116}.
uniprot
proteins
protein_family
Cyclic nucleotide phosphodiesterase family
uniprot
proteins
pubmed
10393044
uniprot
proteins
pubmed
11723116
uniprot
proteins
pubmed
12955149
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15260978
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
25799991
uniprot
proteins
pubmed
9642111
uniprot
proteins
pubmed
9714779
uniprot
proteins
pubmed
9716380
uniprot
proteins
sequence_length
875
uniprot
proteins