Dio2
entrez
65162
canonical
uniprot
P70551
canonical
ensembl
ENSRNOG00000062383
resolver
ensembl
ENSRNOG00055026584
resolver
ensembl
ENSRNOG00060019869
resolver
ensp
ENSRNOP00000093973
resolver
ensp
ENSRNOP00055037615
resolver
ensp
ENSRNOP00060028203
resolver
enst
ENSRNOT00055045883
resolver
enst
ENSRNOT00060034371
resolver
genesymbol
Dio2
resolver
genesymbol_syn
Itdi2
resolver
genesymbol_syn
Txdi2
resolver
uniprot
O70179
resolver
uniprot_entry
IOD2_RAT
resolver
uniprot_sec
O70179
resolver
amino_acid_sequence
MGLLSVDLLITLQILPVFFSNCLFLALYDSVILLKHVALLLSRSKSTRGEWRRMLTSEGLRCVWNSFLLDAYKQVKLGEDAPNSSVVHVSNPEAGNNCASEKTADGAECHLLDFASAERPLVVNFGSATUPPFTRQLPAFRQLVEEFSSVADFLLVYIDEAHPSDGWAVPGDSSMSFEVKKHRNQEDRCAAAHQLLERFSLPPQCQVVADRMDNNANVAYGVAFERVCIVQRRKIAYLGGKGPFSYNLQEVRSWLEKNFSKRUILD
uniprot
proteins
ec_number
1.21.99.4
uniprot
proteins
function
FUNCTION: Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination (PubMed:9709916). Catalyzes the deiodination of L-thyroxine (T4) to 3,5,3'-triiodothyronine (T3) and 3',5'-diiodothyronine (3',5'-T2) to 3'-monoiodothyronine (3'-T1) via outer-ring deiodination (ORD) (By similarity). Catalyzes the deiodination of 3,3',5'-triiodothyronine (rT3) to 3,3'-diiodothyronine (3,3'-T2) via ORD (PubMed:8755651). Catalyzes the phenolic ring deiodinations of 3,3',5'-triiodothyronamine and 3',5'- diiodothyronamine (By similarity). {ECO:0000250|UniProtKB:Q92813, ECO:0000269|PubMed:9709916}.
uniprot
proteins
mass_dalton
29871
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by MARCHF6, leading to its degradation by the proteasome. Deubiquitinated by USP20 and USP33 (By similarity). {ECO:0000250|UniProtKB:Q92813}.
uniprot
proteins
protein_family
Iodothyronine deiodinase family
uniprot
proteins
pubmed
19103603
uniprot
proteins
pubmed
8755651
uniprot
proteins
pubmed
9178860
uniprot
proteins
pubmed
9709916
uniprot
proteins
sequence_length
266
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q92813}; Single-pass type III membrane protein {ECO:0000250|UniProtKB:Q92813}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..34; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins