SCYL1
entrez
57410
canonical
uniprot
Q96KG9
canonical
ensembl
ENSG00000142186
resolver
ensp
ENSP00000270176
resolver
ensp
ENSP00000408192
resolver
ensp
ENSP00000431635
resolver
ensp
ENSP00000436993
resolver
ensp
ENSP00000437254
resolver
ensp
ENSP00000542821
resolver
ensp
ENSP00000542822
resolver
ensp
ENSP00000542829
resolver
ensp
ENSP00000542832
resolver
ensp
ENSP00000542835
resolver
ensp
ENSP00000542836
resolver
ensp
ENSP00000542838
resolver
ensp
ENSP00000542842
resolver
ensp
ENSP00000609514
resolver
ensp
ENSP00000641927
resolver
ensp
ENSP00000655421
resolver
ensp
ENSP00000655422
resolver
ensp
ENSP00000655425
resolver
ensp
ENSP00000680942
resolver
ensp
ENSP00000680945
resolver
ensp
ENSP00000680949
resolver
ensp
ENSP00000680951
resolver
ensp
ENSP00000680961
resolver
ensp
ENSP00000741430
resolver
ensp
ENSP00000791627
resolver
ensp
ENSP00000791629
resolver
enst
ENST00000525364
resolver
enst
ENST00000527009
resolver
genesymbol
SCYL1
resolver
genesymbol_syn
CVAK90
resolver
genesymbol_syn
GKLP
resolver
genesymbol_syn
NTKL
resolver
genesymbol_syn
TAPK
resolver
genesymbol_syn
TEIF
resolver
genesymbol_syn
TRAP
resolver
hgnc
HGNC:14372
resolver
uniprot
A6NJF1
resolver
uniprot
E9PK59
resolver
uniprot
E9PPN3
resolver
uniprot
Q96G50
resolver
uniprot
Q96KG8
resolver
uniprot
Q96KH1
resolver
uniprot
Q9HAW5
resolver
uniprot
Q9HBL3
resolver
uniprot
Q9NR53
resolver
uniprot_entry
E9PK59_HUMAN
resolver
uniprot_entry
E9PPN3_HUMAN
resolver
uniprot_entry
SCYL1_HUMAN
resolver
uniprot_sec
A6NJF1
resolver
uniprot_sec
Q96G50
resolver
uniprot_sec
Q96KG8
resolver
uniprot_sec
Q96KH1
resolver
uniprot_sec
Q9HAW5
resolver
uniprot_sec
Q9HBL3
resolver
uniprot_sec
Q9NR53
resolver
amino_acid_sequence
MWFFARDPVRDFPFELIPEPPEGGLPGPWALHRGRKKATGSPVSIFVYDVKPGAEEQTQVAKAAFKRFKTLRHPNILAYIDGLETEKCLHVVTEAVTPLGIYLKARVEAGGLKELEISWGLHQIVKALSFLVNDCSLIHNNVCMAAVFVDRAGEWKLGGLDYMYSAQGNGGGPPRKGIPELEQYDPPELADSSGRVVREKWSADMWRLGCLIWEVFNGPLPRAAALRNPGKIPKTLVPHYCELVGANPKVRPNPARFLQNCRAPGGFMSNRFVETNLFLEEIQIKEPAEKQKFFQELSKSLDAFPEDFCRHKVLPQLLTAFEFGNAGAVVLTPLFKVGKFLSAEEYQQKIIPVVVKMFSSTDRAMRIRLLQQMEQFIQYLDEPTVNTQIFPHVVHGFLDTNPAIREQTVKSMLLLAPKLNEANLNVELMKHFARLQAKDEQGPIRCNTTVCLGKIGSYLSASTRHRVLTSAFSRATRDPFAPSRVAGVLGFAATHNLYSMNDCAQKILPVLCGLTVDPEKSVRDQAFKAIRSFLSKLESVSEDPTQLEEVEKDVHAASSPGMGGAAASWAGWAVTGVSSLTSKLIRSHPTTAPTETNIPQRPTPEGVPAPAPTPVPATPTTSGHWETQEEDKDTAEDSSTADRWDDEDWGSLEQEAESVLAQQDDWSTGGQVSRASQVSNSDHKSSKSPESDWSSWEAEGSWEQGWQEPSSQEPPPDGTRLASEYNWGGPESSDKGDPFATLSARPSTQPRPDSWGEDNWEGLETDSRQVKAELARKKREERRREMEAKRAERKVAKGPMKLGARKLD
uniprot
proteins
disease_involvement
DISEASE: Spinocerebellar ataxia, autosomal recessive, 21 (SCAR21) [MIM:616719]: A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCAR21 is characterized by cerebellar atrophy and ataxia with onset in early childhood. Patients also manifest recurrent episodes of liver failure, hepatic fibrosis and a peripheral neuropathy. {ECO:0000269|PubMed:26581903}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Regulates COPI-mediated retrograde protein traffic at the interface between the Golgi apparatus and the endoplasmic reticulum (PubMed:18556652). Involved in the maintenance of the Golgi apparatus morphology (PubMed:26581903). {ECO:0000269|PubMed:18556652, ECO:0000269|PubMed:26581903}.; FUNCTION: [Isoform 6]: Acts as a transcriptional activator. It binds to three different types of GC-rich DNA binding sites (box-A, -B and -C) in the beta-polymerase promoter region. It also binds to the TERT promoter region. {ECO:0000269|PubMed:15963946}.
uniprot
proteins
mass_dalton
89631
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10843802
uniprot
proteins
pubmed
12036289
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15504359
uniprot
proteins
pubmed
15963946
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16903783
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18556652
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26581903
uniprot
proteins
sequence_length
808
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:18556652}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000269|PubMed:18556652}. Golgi apparatus, cis-Golgi network {ECO:0000269|PubMed:18556652}. Note=Localized to the Endoplasmic reticulum-Golgi intermediate and cis-Golgi in an ARF1-independent manner.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Note=Cytoplasmic throughout the cell cycle.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Note=Cytoplasmic throughout the cell cycle.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic during interphase and centrosomal during mitosis, it localizes to the centrosomes in a microtubule-independent manner.; SUBCELLULAR LOCATION: [Isoform 6]: Nucleus {ECO:0000269|PubMed:15504359}.
uniprot
proteins