Lamp2
entrez
24944
canonical
uniprot
P17046
canonical
ensembl
ENSRNOG00000000164
resolver
ensp
ENSRNOP00000000177
resolver
ensp
ENSRNOP00000092818
resolver
ensp
ENSRNOP00000095159
resolver
enst
ENSRNOT00000000177
resolver
enst
ENSRNOT00000099330
resolver
enst
ENSRNOT00000107735
resolver
genesymbol
Lamp2
resolver
genesymbol_syn
Lamp-2
resolver
uniprot
A0A8I6AHB3
resolver
uniprot
A0A8I6AMZ0
resolver
uniprot
F1LLX8
resolver
uniprot
Q6P6W1
resolver
uniprot_entry
A0A8I6AHB3_RAT
resolver
uniprot_entry
A0A8I6AMZ0_RAT
resolver
uniprot_entry
LAMP2_RAT
resolver
uniprot_sec
F1LLX8
resolver
uniprot_sec
Q6P6W1
resolver
amino_acid_sequence
MRLLSPVTGSKLVLLFLFLGAVRSDALKLNLTDSKGTCLYAEWEMNFTITYEALKVNETVTITVPDKVTYNGSSCGDDKNGAKIMIQYGSTLSWAVNFTKEASQYFINNITLSYNTNDTKTFPGAVPKGILTVIIPVGSQLPLGVIFKCSSVLTFNLSPVVQHYWGIHLQAFVQNGTVSKHEQVCKEDKTATTVAPIIHTTVPSPTTTLTPTSIPVPTPTVGNYTISNGNATCLLATMGLQLNITEEKVPFIFNINPAITNFTGSCQPQTAQLRLNNSQIKYLDFIFAVKNEKRFYLKEVNVNMYLANGSAFHVSNNNLSFWDAPLGSSYMCNKEQVVSVSRTFQINTFNLKVQPFNVTKGEYSTAQDCSADEDNFLVPIAVGAALGGVLILVLLAYFIGLKRHHTGYEQF
uniprot
proteins
function
FUNCTION: Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation and autophagy (PubMed:11082038, PubMed:8662539). Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity (By similarity). Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:11082038, PubMed:8662539). Functions by binding target proteins, such as GAPDH, GPX4, NLRP3 and MLLT11, and targeting them for lysosomal degradation (PubMed:11082038, PubMed:18644871, PubMed:8662539). In the chaperone-mediated autophagy, acts downstream of chaperones, such as HSPA8/HSC70, which recognize and bind substrate proteins and mediate their recruitment to lysosomes, where target proteins bind LAMP2 (PubMed:18644871). Plays a role in lysosomal protein degradation in response to starvation (PubMed:11082038). Required for the fusion of autophagosomes with lysosomes during autophagy (By similarity). Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (By similarity). Required for normal degradation of the contents of autophagosomes (By similarity). Required for efficient MHC class II-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHC II subunits (By similarity). Is not required for efficient MHC class II-mediated presentation of endogenous antigens (By similarity). {ECO:0000250|UniProtKB:P13473, ECO:0000269|PubMed:11082038, ECO:0000269|PubMed:18644871, ECO:0000269|PubMed:8662539}.
uniprot
proteins
mass_dalton
45156
uniprot
proteins
post_translational_modification
PTM: Extensively N-glycosylated (PubMed:1794981, PubMed:18644871). Contains a minor proportion of O-linked glycans (PubMed:1794981). Contains sialylated glycans (PubMed:1794981). {ECO:0000269|PubMed:1794981, ECO:0000269|PubMed:18644871}.
uniprot
proteins
protein_family
LAMP family
uniprot
proteins
pubmed
11082038
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1794981
uniprot
proteins
pubmed
18644871
uniprot
proteins
pubmed
2142158
uniprot
proteins
pubmed
2590192
uniprot
proteins
pubmed
8662539
uniprot
proteins
sequence_length
411
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:11082038, ECO:0000269|PubMed:1794981, ECO:0000269|PubMed:18644871, ECO:0000269|PubMed:2590192, ECO:0000269|PubMed:8662539}; Single-pass type I membrane protein {ECO:0000269|PubMed:11082038}. Endosome membrane {ECO:0000250|UniProtKB:P13473}; Single-pass type I membrane protein {ECO:0000255|PROSITE-ProRule:PRU00740}. Cell membrane {ECO:0000250|UniProtKB:P13473}; Single-pass type I membrane protein {ECO:0000255|PROSITE-ProRule:PRU00740}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250|UniProtKB:P17047}. Note=This protein shuttles between lysosomes, endosomes, and the plasma membrane. {ECO:0000250|UniProtKB:P13473}.
uniprot
proteins
transmembrane_region
TRANSMEM 377..400; /note="Helical"; /evidence="ECO:0000255|PROSITE-ProRule:PRU00740
uniprot
proteins