CAT
entrez
847
canonical
uniprot
P04040
canonical
ensembl
ENSG00000121691
resolver
ensp
ENSP00000241052
resolver
enst
ENST00000241052
resolver
genesymbol
CAT
resolver
hgnc
HGNC:1516
resolver
uniprot
A0A384P5Q0
resolver
uniprot
A8K6C0
resolver
uniprot
B2RCZ9
resolver
uniprot
D3DR07
resolver
uniprot
Q2M1U4
resolver
uniprot
Q4VXX5
resolver
uniprot
Q9BWT9
resolver
uniprot
Q9UC85
resolver
uniprot_entry
A0A384P5Q0_HUMAN
resolver
uniprot_entry
CATA_HUMAN
resolver
uniprot_sec
A8K6C0
resolver
uniprot_sec
B2RCZ9
resolver
uniprot_sec
D3DR07
resolver
uniprot_sec
Q2M1U4
resolver
uniprot_sec
Q4VXX5
resolver
uniprot_sec
Q9BWT9
resolver
uniprot_sec
Q9UC85
resolver
amino_acid_sequence
MADSRDPASDQMQHWKEQRAAQKADVLTTGAGNPVGDKLNVITVGPRGPLLVQDVVFTDEMAHFDRERIPERVVHAKGAGAFGYFEVTHDITKYSKAKVFEHIGKKTPIAVRFSTVAGESGSADTVRDPRGFAVKFYTEDGNWDLVGNNTPIFFIRDPILFPSFIHSQKRNPQTHLKDPDMVWDFWSLRPESLHQVSFLFSDRGIPDGHRHMNGYGSHTFKLVNANGEAVYCKFHYKTDQGIKNLSVEDAARLSQEDPDYGIRDLFNAIATGKYPSWTFYIQVMTFNQAETFPFNPFDLTKVWPHKDYPLIPVGKLVLNRNPVNYFAEVEQIAFDPSNMPPGIEASPDKMLQGRLFAYPDTHRHRLGPNYLHIPVNCPYRARVANYQRDGPMCMQDNQGGAPNYYPNSFGAPEQQPSALEHSIQYSGEVRRFNTANDDNVTQVRAFYVNVLNEEQRKRLCENIAGHLKDAQIFIQKKAVKNFTEVHPDYGSHIQALLDKYNAEKPKNAIHTFVQSGSHLAAREKANL
uniprot
proteins
disease_involvement
DISEASE: Acatalasemia (ACATLAS) [MIM:614097]: A metabolic disorder characterized by a total or near total loss of catalase activity in red cells. It is often associated with ulcerating oral lesions. Acatalasemia is inherited as an autosomal recessive trait. {ECO:0000269|PubMed:2308162}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
1.11.1.6
uniprot
proteins
function
FUNCTION: Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide (PubMed:7882369). Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells (PubMed:7882369). {ECO:0000269|PubMed:7882369}.
uniprot
proteins
mass_dalton
59756
uniprot
proteins
mutagenesis
MUTAGEN 517..519; /note="SHL->TQV: Does not affect localization to peroxisomes."; /evidence="ECO:0000269|PubMed:8769411"; MUTAGEN 524..527; /note="Missing: Abolished localization to peroxisomes."; /evidence="ECO:0000269|PubMed:8769411"; MUTAGEN 526; /note="N->D: Abolished localization to peroxisomes."; /evidence="ECO:0000269|PubMed:8769411
uniprot
proteins
protein_family
Catalase family
uniprot
proteins
pubmed
10656833
uniprot
proteins
pubmed
10666617
uniprot
proteins
pubmed
11134921
uniprot
proteins
pubmed
11728823
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21976670
uniprot
proteins
pubmed
2308162
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
3755525
uniprot
proteins
pubmed
3755526
uniprot
proteins
pubmed
6548744
uniprot
proteins
pubmed
7882369
uniprot
proteins
pubmed
8282800
uniprot
proteins
pubmed
8769411
uniprot
proteins
sequence_length
527
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome matrix {ECO:0000269|PubMed:21976670, ECO:0000269|PubMed:8769411}.
uniprot
proteins