CTDSP2
entrez
10106
canonical
uniprot
O14595
canonical
ensembl
ENSG00000175215
resolver
ensp
ENSP00000381148
resolver
ensp
ENSP00000691381
resolver
enst
ENST00000398073
resolver
genesymbol
CTDSP2
resolver
genesymbol_syn
NIF2
resolver
genesymbol_syn
OS4
resolver
genesymbol_syn
SCP2
resolver
hgnc
HGNC:17077
resolver
uniprot
A8K5H4
resolver
uniprot
Q53ZR2
resolver
uniprot
Q6NZY3
resolver
uniprot
Q9UEX1
resolver
uniprot_entry
CTDS2_HUMAN
resolver
uniprot_sec
A8K5H4
resolver
uniprot_sec
Q53ZR2
resolver
uniprot_sec
Q6NZY3
resolver
uniprot_sec
Q9UEX1
resolver
amino_acid_sequence
MEHGSIITQARREDALVLTKQGLVSKSSPKKPRGRNIFKALFCCFRAQHVGQSSSSTELAAYKEEANTIAKSDLLQCLQYQFYQIPGTCLLPEVTEEDQGRICVVIDLDETLVHSSFKPINNADFIVPIEIEGTTHQVYVLKRPYVDEFLRRMGELFECVLFTASLAKYADPVTDLLDRCGVFRARLFRESCVFHQGCYVKDLSRLGRDLRKTLILDNSPASYIFHPENAVPVQSWFDDMADTELLNLIPIFEELSGAEDVYTSLGQLRAP
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas. {ECO:0000269|PubMed:12721286, ECO:0000269|PubMed:15681389}.
uniprot
proteins
mass_dalton
30664
uniprot
proteins
pubmed
12721286
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15681389
uniprot
proteins
pubmed
18058037
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
9315096
uniprot
proteins
sequence_length
271
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins