NLRP2B
entrez
286430
canonical
uniprot
P0DMW2
canonical
ensembl
ENSG00000215174
resolver
ensp
ENSP00000488995
resolver
enst
ENST00000434992
resolver
genesymbol
NLRP2B
resolver
genesymbol_syn
CLRX.1
resolver
genesymbol_syn
NLRP2P
resolver
genesymbol_syn
NOD24
resolver
genesymbol_syn
POP4
resolver
hgnc
HGNC:29887
resolver
uniprot_entry
PYDC4_HUMAN
resolver
amino_acid_sequence
MVSSAQLDFNLQALLGQLSQDDLCKFKSLIRTVSLGNELQKIPQT
uniprot
proteins
function
FUNCTION: May function as a negative regulator of NF-kappa-B by preventing RELA/p65 phosphorylation at 'Ser-536', thereby inhibiting its transcriptional activity. Through NF-kappa-B regulation may control cytokine release upon Toll-like receptors activation and therefore play a role in modulation of innate immunity. May also play a role in cell cycle progression and apoptotic process. {ECO:0000269|PubMed:24871464}.
uniprot
proteins
mass_dalton
4993
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
24871464
uniprot
proteins
sequence_length
45
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:24871464}. Nucleus {ECO:0000269|PubMed:24871464}. Note=Targeted to the nucleus upon TNF treatment. {ECO:0000269|PubMed:24871464}.
uniprot
proteins