Kcnip3
entrez
56461
canonical
uniprot
Q9QXT8
canonical
ensembl
ENSMUSG00000079056
resolver
ensp
ENSMUSP00000028850
resolver
ensp
ENSMUSP00000085896
resolver
ensp
ENSMUSP00000099504
resolver
ensp
ENSMUSP00000159973
resolver
enst
ENSMUST00000028850
resolver
enst
ENSMUST00000088538
resolver
enst
ENSMUST00000249876
resolver
genesymbol
Kcnip3
resolver
genesymbol_syn
Csen
resolver
genesymbol_syn
Dream
resolver
genesymbol_syn
Kchip3
resolver
uniprot
A0AAQ4VMS2
resolver
uniprot
A2AHT3
resolver
uniprot
F6Z3Y1
resolver
uniprot
Q3YAA9
resolver
uniprot
Q3YAB0
resolver
uniprot
Q924L0
resolver
uniprot
Q99PH9
resolver
uniprot
Q99PI0
resolver
uniprot
Q99PI2
resolver
uniprot
Q99PI3
resolver
uniprot
Q9JHZ5
resolver
uniprot_entry
A0AAQ4VMS2_MOUSE
resolver
uniprot_entry
A2AHT3_MOUSE
resolver
uniprot_entry
CSEN_MOUSE
resolver
uniprot_entry
F6Z3Y1_MOUSE
resolver
uniprot_entry
Q3YAA9_MOUSE
resolver
uniprot_entry
Q3YAB0_MOUSE
resolver
uniprot_sec
Q924L0
resolver
uniprot_sec
Q99PH9
resolver
uniprot_sec
Q99PI0
resolver
uniprot_sec
Q99PI2
resolver
uniprot_sec
Q99PI3
resolver
uniprot_sec
Q9JHZ5
resolver
amino_acid_sequence
MQRTKEAVKASDGNLLGDPGRIPLSKRESIKWQRPRFTRQALMRCCLIKWILSSAAPQGSDSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSLYRGFKNECPTGLVDEDTFKLIYSQFFPQGDATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLRGTVHEKLKWAFNLYDINKDGCITKEEMLAIMKSIYDMMGRHTYPILREDAPLEHVERFFQKMDRNQDGVVTIDEFLETCQKDENIMNSMQLFENVI
uniprot
proteins
function
FUNCTION: Calcium-dependent transcriptional repressor that binds to the DRE element of genes including PDYN and FOS. Affinity for DNA is reduced upon binding to calcium and enhanced by binding to magnesium. Seems to be involved in nociception. {ECO:0000269|PubMed:11792319, ECO:0000269|PubMed:14534243}.; FUNCTION: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels, such as KCND2/Kv4.2 and KCND3/Kv4.3. Modulates channel expression at the cell membrane, gating characteristics, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. {ECO:0000269|PubMed:20943905, ECO:0000269|PubMed:22311982}.; FUNCTION: May play a role in the regulation of PSEN2 proteolytic processing and apoptosis. Together with PSEN2 involved in modulation of amyloid-beta formation (By similarity). {ECO:0000250|UniProtKB:Q9Y2W7}.
uniprot
proteins
mass_dalton
29463
uniprot
proteins
mutagenesis
MUTAGEN 186; /note="E->Q: Abolishes calcium-binding."; /evidence="ECO:0000269|PubMed:15746104"; MUTAGEN 234; /note="E->Q: Abolishes calcium-binding."; /evidence="ECO:0000269|PubMed:15746104
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. Palmitoylation enhances association with the plasma membrane (By similarity). {ECO:0000250}.; PTM: Proteolytically cleaved by caspase-3. {ECO:0000250}.
uniprot
proteins
protein_family
Recoverin family
uniprot
proteins
pubmed
10676964
uniprot
proteins
pubmed
11161465
uniprot
proteins
pubmed
11598014
uniprot
proteins
pubmed
11792319
uniprot
proteins
pubmed
12451113
uniprot
proteins
pubmed
12646414
uniprot
proteins
pubmed
14534243
uniprot
proteins
pubmed
15363885
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15746104
uniprot
proteins
pubmed
18201103
uniprot
proteins
pubmed
19713751
uniprot
proteins
pubmed
20943905
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22311982
uniprot
proteins
sequence_length
256
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22311982}. Cell membrane {ECO:0000250|UniProtKB:Q9Y2W7}; Lipid-anchor. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9Y2W7}. Golgi apparatus {ECO:0000250|UniProtKB:Q9Y2W7}. Nucleus {ECO:0000250|UniProtKB:Q9Y2W7}. Note=The sumoylated form is present only in the nucleus. In the presence of PSEN2, associated with the endoplasmic reticulum and Golgi. {ECO:0000250|UniProtKB:Q9Y2W7}.
uniprot
proteins