Trim9
entrez
155812
canonical
uniprot
Q91ZY8
canonical
ensembl
ENSRNOG00000007031
resolver
ensembl
ENSRNOG00055009004
resolver
ensembl
ENSRNOG00060006594
resolver
ensembl
ENSRNOG00065007016
resolver
ensp
ENSRNOP00000009559
resolver
ensp
ENSRNOP00000077889
resolver
ensp
ENSRNOP00000086601
resolver
ensp
ENSRNOP00000088626
resolver
ensp
ENSRNOP00055012197
resolver
ensp
ENSRNOP00060008091
resolver
ensp
ENSRNOP00065008084
resolver
enst
ENSRNOT00000009560
resolver
enst
ENSRNOT00000094403
resolver
enst
ENSRNOT00000106074
resolver
enst
ENSRNOT00055015238
resolver
enst
ENSRNOT00060010879
resolver
enst
ENSRNOT00065011008
resolver
genesymbol
Trim9
resolver
genesymbol_syn
Spring
resolver
uniprot
A0A8I5XWL7
resolver
uniprot
A0A8I6AAA7
resolver
uniprot_entry
A0A8I5XWL7_RAT
resolver
uniprot_entry
A0A8I6AAA7_RAT
resolver
uniprot_entry
TRIM9_RAT
resolver
amino_acid_sequence
MEEMEEELKCPVCGSFYREPIILPCSHNLCQACARNILVQTPESESPQSRRASGSGVSDYDYLDLDKMSLYSEADSGYGSYGGFASAPTTPCQKSPNGVRVFPPAMPPPPTHLSPALAPVPRNSCITCPQCHRSLILDDRGLRGFPKNRVLEGVIDRYQQSKAAALKCQLCEKAPKEATVMCEQCDVFYCDPCRLRCHPPRGPLAKHRLVPPAQGRVSRRLSPRKVSTCTDHELENHSMYCVQCKMPVCYQCLEEGKHSSHEVKALGAMWKLHKSQLSQALNGLSDRAKEAKEFLVQLRTMVQQIQENSVEFEACLVAQCDALIDALNRRKAQLLARVNKEHEHKLKVVRDQISHCTVKLRQTTGLMEYCLEVIKENDPSGFLQISDALIRRVHLTEDQWGKGTLTPRMTTDFDLSLDNSPLLQSIHQLDFVQVKASSPVPATPILQLEECCTHNNSATLSWKQPPLSTVAADGYILELDDGSGGQFREVYVGKETMCTVDGLHFNSTYNARVKAFNKTGVSPYSKTLVLQTSEVAWFAFDPGSAHSDIIFSNDNLTVTCSSYDDRVVLGKTGFSKGVHYWELTIDRYDNHPDPAFGVARIDVMKDMMLGKDDKAWAMYVDNNRSWFMHNNSHTNRTEGGITKGATIGVLLDLNRKTLTFFVNNEQQGPIAFENVEGLFFPAVSLNRNVQVTLHTGLPVPDFYSSRASIA
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation (By similarity). Regulates filopodial dynamics in brain by promoting the ubiquitination and degradation of actin polymerase VASP; this activity is antagonized by TRIM67 (By similarity). May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation. {ECO:0000250|UniProtKB:Q8C7M3, ECO:0000250|UniProtKB:Q9C026}.
uniprot
proteins
mass_dalton
79206
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9C026}.
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated. Poly-ubiquitinated in cultured cells, whereas it is monoubiquitinated in vitro (By similarity). {ECO:0000250|UniProtKB:Q9C026}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
11524423
uniprot
proteins
pubmed
20085810
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
710
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000269|PubMed:11524423}. Synapse {ECO:0000269|PubMed:11524423}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11524423}. Cytoplasm {ECO:0000250|UniProtKB:Q9C026}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9C026}. Note=Enriched at synaptic terminals where it exists in a soluble form and a synaptic vesicle-associated form. Associated with the cytoskeleton (PubMed:11524423). Found in proximal dendrites of pyramidal neurons in the cerebral cortex and hippocampus, and Purkinje cells in the cerebellum (By similarity). {ECO:0000250|UniProtKB:Q9C026, ECO:0000269|PubMed:11524423}.
uniprot
proteins