TSSK2
entrez
23617
canonical
uniprot
Q96PF2
canonical
ensembl
ENSG00000206203
resolver
ensp
ENSP00000382544
resolver
enst
ENST00000399635
resolver
genesymbol
TSSK2
resolver
genesymbol_syn
DGSG
resolver
genesymbol_syn
SPOGA2
resolver
genesymbol_syn
STK22B
resolver
hgnc
HGNC:11401
resolver
uniprot
A0ZT99
resolver
uniprot
Q8IY55
resolver
uniprot_entry
A0ZT99_HUMAN
resolver
uniprot_entry
TSSK2_HUMAN
resolver
uniprot_sec
Q8IY55
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation on Thr-174, potentially by autophosphorylation. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MDDATVLRKKGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRKKTPTDFVERFLPREMDILATVNHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDIVHRDLKCENLLLDKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQSIPYQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDFPRSKNLTCECKDLIYRMLQPDVSQRLHIDEILSHSWLQPPKPKATSSASFKREGEGKYRAECKLDTKTGLRPDHRPDHKLGAKTQHRLLVVPENENRMEDRLAETSRAKDHHISGAEVGKAST
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates TSKS at 'Ser-288' and SPAG16. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required for the transformation of a ring-shaped structure around the base of the flagellum originating from the chromatoid body. {ECO:0000269|PubMed:15044604, ECO:0000269|PubMed:18533145, ECO:0000269|PubMed:20729278}.
uniprot
proteins
mass_dalton
40939
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. {ECO:0000269|PubMed:15044604}.; PTM: Ubiquitinated; HSP90 activity negatively regulates ubiquitination and degradation. {ECO:0000250|UniProtKB:O54863}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
15044604
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17566264
uniprot
proteins
pubmed
18495105
uniprot
proteins
pubmed
18533145
uniprot
proteins
pubmed
19926886
uniprot
proteins
pubmed
20729278
uniprot
proteins
pubmed
8776594
uniprot
proteins
sequence_length
358
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:18495105}. Note=Present in the cytoplasm of elongating spermatids. In spermatozoa, localizes in the equatorial segment, neck, the midpiece and in a specific sperm head compartment (By similarity). In spermatids, concentrates in centrioles during flagellogenesis. {ECO:0000250}.
uniprot
proteins