DHRS3
entrez
9249
canonical
uniprot
O75911
canonical
ensembl
ENSG00000162496
resolver
ensp
ENSP00000480439
resolver
ensp
ENSP00000519783
resolver
ensp
ENSP00000519784
resolver
ensp
ENSP00000648463
resolver
enst
ENST00000714541
resolver
enst
ENST00000714542
resolver
genesymbol
DHRS3
resolver
genesymbol_syn
RDH17
resolver
genesymbol_syn
SDR16C1
resolver
hgnc
HGNC:17693
resolver
uniprot
A0AAQ5BI35
resolver
uniprot
B2R7F3
resolver
uniprot
Q5VUY3
resolver
uniprot
Q6UY38
resolver
uniprot
Q9BUC8
resolver
uniprot_entry
A0AAQ5BI35_HUMAN
resolver
uniprot_entry
DHRS3_HUMAN
resolver
uniprot_sec
B2R7F3
resolver
uniprot_sec
Q5VUY3
resolver
uniprot_sec
Q6UY38
resolver
uniprot_sec
Q9BUC8
resolver
amino_acid_sequence
MVWKRLGALVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPPLKPETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCMNTFKGRT
uniprot
proteins
disease_involvement
DISEASE: Craniosynostosis-scoliosis syndrome (CRSS) [MIM:621499]: An autosomal recessive disorder characterized by coronal craniosynostosis, dysmorphic facial features, congenital heart disease, and scoliosis. {ECO:0000269|PubMed:40519748}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
1.1.1.300
uniprot
proteins
function
FUNCTION: Catalyzes the reduction of all-trans-retinal to all-trans-retinol in the presence of NADPH (PubMed:9705317). It limits excessive synthesis of all-trans retinoic acid (RA) from all-trans-retinal (PubMed:40519748). {ECO:0000269|PubMed:40519748, ECO:0000269|PubMed:9705317}.
uniprot
proteins
mass_dalton
33548
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
11861404
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
40519748
uniprot
proteins
pubmed
9705317
uniprot
proteins
sequence_length
302
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 170..190; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 195..215; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 253..273; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins