Cd300ld3
entrez
382551
canonical
uniprot
Q6SJQ5
canonical
ensembl
ENSMUSG00000069607
resolver
ensp
ENSMUSP00000090116
resolver
enst
ENSMUST00000092459
resolver
genesymbol
Cd300ld3
resolver
genesymbol_syn
Cd300lh
resolver
genesymbol_syn
Clm3
resolver
genesymbol_syn
Lmir7
resolver
uniprot_entry
CLM3_MOUSE
resolver
amino_acid_sequence
MWQFPALLFLFLPGCCTAQDPVTGPEEVSGQEQGSLTVQCRYDSGWKDYKKYWCRGAYWKSCEILVETDASEQLVKENRVSIRDDQTDFIFTVTMEDLRMSDADIYWCGITKAGTDPMFKVNVNIDPEISTTIMTTTATVLPSTVLTSTVLTSTVLTPTTPTTESIGTENIGQVTQNSLFIWSLLSSISFLLMVFVVVPLLLSMLSAVLWVNRPQRHYGGGEIGLVETHRSDALDGEKHFPGDEK
uniprot
proteins
function
FUNCTION: Acts as an activating receptor inducing cytokine production in mast cells. Can act as a positive regulator of TLR9 signaling in macrophages, leading to enhanced production of pro-inflammatory cytokines. {ECO:0000269|PubMed:20817736, ECO:0000269|PubMed:21940676}.
uniprot
proteins
mass_dalton
27312
uniprot
proteins
mutagenesis
MUTAGEN 177..182; /note="NSLFIW->SRPHTR: Increases surface expression in transfected pro-B cells and enhances interaction with FCER1G. Slightly increases surface expression and enhances interaction with FCER1G; when associated with 189-Y--L-198."; /evidence="ECO:0000269|PubMed:20817736"; MUTAGEN 189..198; /note="SFLLMVFVVV->YFLLMVFVEL: Reduces surface expression in transfected pro-B cells and enhances interaction with FCER1G. Slightly increases surface expression in transfected pro-B cells and enhances interaction with FCER1G; when associated with 177-S--R-182."; /evidence="ECO:0000269|PubMed:20817736
uniprot
proteins
protein_family
CD300 family
uniprot
proteins
pubmed
14662855
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20817736
uniprot
proteins
pubmed
21940676
uniprot
proteins
sequence_length
245
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Early endosome {ECO:0000269|PubMed:21940676}. Lysosome {ECO:0000269|PubMed:21940676}.
uniprot
proteins
transmembrane_region
TRANSMEM 190..210; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins