FCGR1A
entrez
2209
canonical
uniprot
P12314
canonical
ensembl
ENSG00000150337
resolver
ensp
ENSP00000358165
resolver
ensp
ENSP00000394279
resolver
ensp
ENSP00000536835
resolver
ensp
ENSP00000536836
resolver
ensp
ENSP00000536837
resolver
ensp
ENSP00000761604
resolver
genesymbol
FCGR1A
resolver
genesymbol_syn
FCG1
resolver
genesymbol_syn
FCGR1
resolver
genesymbol_syn
IGFR1
resolver
hgnc
HGNC:3613
resolver
uniprot
P12315
resolver
uniprot
Q5QNW7
resolver
uniprot
Q92495
resolver
uniprot
Q92663
resolver
uniprot_entry
FCGR1_HUMAN
resolver
uniprot_sec
P12315
resolver
uniprot_sec
Q5QNW7
resolver
uniprot_sec
Q92495
resolver
uniprot_sec
Q92663
resolver
amino_acid_sequence
MWFLTTLLLWVPVDGQVDTTKAVITLQPPWVSVFQEETVTLHCEVLHLPGSSSTQWFLNGTATQTSTPSYRITSASVNDSGEYRCQRGLSGRSDPIQLEIHRGWLLLQVSSRVFTEGEPLALRCHAWKDKLVYNVLYYRNGKAFKFFHWNSNLTILKTNISHNGTYHCSGMGKHRYTSAGISVTVKELFPAPVLNASVTSPLLEGNLVTLSCETKLLLQRPGLQLYFSFYMGSKTLRGRNTSSEYQILTARREDSGLYWCEAATEDGNVLKRSPELELQVLGLQLPTPVWFHVLFYLAVGIMFLVNTVLWVTIRKELKRKKKWDLEISLDSGHEKKVISSLQEDRHLEEELKCQEQKEEQLQEGVHRKEPQGAT
uniprot
proteins
function
FUNCTION: High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Mediates IgG effector functions on monocytes triggering antibody-dependent cellular cytotoxicity (ADCC) of virus-infected cells. {ECO:0000269|PubMed:10397749, ECO:0000269|PubMed:10514529, ECO:0000269|PubMed:11711607, ECO:0000269|PubMed:21965667, ECO:0000269|PubMed:8611682, ECO:0000269|PubMed:9881690}.
uniprot
proteins
mass_dalton
42632
uniprot
proteins
mutagenesis
MUTAGEN 173; /note="K->A: 2- to 5-fold reduction of binding affinity for IgG1, IgG3 and IgG4."; /evidence="ECO:0000269|PubMed:25561553"; MUTAGEN 173; /note="K->E: 3- to 10-fold reduction of binding affinity for IgG1, IgG3 and IgG4."; /evidence="ECO:0000269|PubMed:25561553"; MUTAGEN 174; /note="H->A: 2- to 5-fold reduction of binding affinity for IgG1, IgG3 and IgG4."; /evidence="ECO:0000269|PubMed:25561553"; MUTAGEN 174; /note="H->E: 15- to 30-fold reduction of binding affinity for IgG1, IgG3 and IgG4."; /evidence="ECO:0000269|PubMed:25561553"; MUTAGEN 175; /note="R->A: 20-fold reduction of binding affinity for IgG1, IgG3 and IgG4."; /evidence="ECO:0000269|PubMed:25561553"; MUTAGEN 175; /note="R->E: 3- to 10-fold reduction of binding affinity for IgG1, IgG3 and IgG4."; /evidence="ECO:0000269|PubMed:25561553"; MUTAGEN 306; /note="N->D: Decreases cell membrane expression by 50% in absence of FCER1G."; /evidence="ECO:0000269|PubMed:12756162"; MUTAGEN 306; /note="N->G: Increases cell membrane expression in absence of FCER1G."; /evidence="ECO:0000269|PubMed:12756162
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine residues. {ECO:0000250}.
uniprot
proteins
protein_family
FCGR1 family
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
10397749
uniprot
proteins
pubmed
10514529
uniprot
proteins
pubmed
10781611
uniprot
proteins
pubmed
11711607
uniprot
proteins
pubmed
12756162
uniprot
proteins
pubmed
1379234
uniprot
proteins
pubmed
1402657
uniprot
proteins
pubmed
1430234
uniprot
proteins
pubmed
15229321
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18023480
uniprot
proteins
pubmed
18322202
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
21965667
uniprot
proteins
pubmed
25561553
uniprot
proteins
pubmed
28566370
uniprot
proteins
pubmed
2911749
uniprot
proteins
pubmed
2974947
uniprot
proteins
pubmed
37421619
uniprot
proteins
pubmed
8064233
uniprot
proteins
pubmed
8611682
uniprot
proteins
pubmed
9881690
uniprot
proteins
sequence_length
374
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12756162, ECO:0000269|PubMed:8611682}; Single-pass type I membrane protein {ECO:0000269|PubMed:12756162, ECO:0000269|PubMed:8611682}. Note=Stabilized at the cell membrane through interaction with FCER1G.
uniprot
proteins
transmembrane_region
TRANSMEM 293..313; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins