MAPDA
entrez
161823
canonical
uniprot
Q6DHV7
canonical
ensembl
ENSG00000168803
resolver
ensp
ENSP00000374302
resolver
ensp
ENSP00000398744
resolver
ensp
ENSP00000413074
resolver
ensp
ENSP00000456242
resolver
ensp
ENSP00000578804
resolver
ensp
ENSP00000578805
resolver
ensp
ENSP00000578806
resolver
ensp
ENSP00000600953
resolver
ensp
ENSP00000622096
resolver
ensp
ENSP00000645178
resolver
ensp
ENSP00000645179
resolver
ensp
ENSP00000794563
resolver
ensp
ENSP00000794564
resolver
genesymbol
MAPDA
resolver
genesymbol_syn
ADAL
resolver
genesymbol_syn
ADAL1
resolver
hgnc
HGNC:31853
resolver
uniprot
A6NHZ3
resolver
uniprot
B4DQM8
resolver
uniprot_entry
ADAL_HUMAN
resolver
uniprot_sec
A6NHZ3
resolver
uniprot_sec
B4DQM8
resolver
amino_acid_sequence
MIEAEEQQPCKTDFYSELPKVELHAHLNGSISSHTMKKLIAQKPDLKIHDQMTVIDKGKKRTLEECFQMFQTIHQLTSSPEDILMVTKDVIKEFADDGVKYLELRSTPRRENATGMTKKTYVESILEGIKQSKQENLDIDVRYLIAVDRRGGPLVAKETVKLAEEFFLSTEGTVLGLDLSGDPTVGQAKDFLEPLLEAKKAGLKLALHLSEIPNQKKETQILLDLLPDRIGHGTFLNSGEGGSLDLVDFVRQHRIPLELCLTSNVKSQTVPSYDQHHFGFWYSIAHPSVICTDDKGVFATHLSQEYQLAAETFNLTQSQVWDLSYESINYIFASDSTRSELRKKWNHLKPRVLHI
uniprot
proteins
ec_number
3.5.4.-
uniprot
proteins
function
FUNCTION: Deaminase involved in the detoxification of modified adenosines containing N(6)-methylated adenine (m6A) post-transcriptional modification (PubMed:40840445). Modified nucleosides are derived from the degradation of RNAs (mRNAs, rRNAs and tRNAs) and possess intrinsic cytotoxicity and must be cleared to prevent metabolic dysfunction (PubMed:40840445). Acts downstream of ADK and catalyzes the hydrolysis of the free cytosolic methylated adenosine nucleotides N(6)-methyl-AMP (m6AMP), N(6),N(6)-dimethyl-AMP (m6,6AMP) and N(6)-isopentenyl-AMP (i6AMP) to produce inositol monophosphate (IMP) (PubMed:21755941, PubMed:29884623, PubMed:40840445). Catalyzes the removal of different alkyl groups not only from N6-substituted purine or 2-aminopurine nucleoside monophosphates but also from O6-substituted compounds in vitro (PubMed:21755941). {ECO:0000269|PubMed:21755941, ECO:0000269|PubMed:29884623, ECO:0000269|PubMed:40840445}.
uniprot
proteins
mass_dalton
40264
uniprot
proteins
protein_family
Adenosine and AMP deaminases family
uniprot
proteins
protein_family
Metallo-dependent hydrolases superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
21755941
uniprot
proteins
pubmed
29884623
uniprot
proteins
pubmed
39190717
uniprot
proteins
pubmed
40840445
uniprot
proteins
sequence_length
355
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8LPL7}.
uniprot
proteins