Apbb1
entrez
29722
canonical
uniprot
P46933
canonical
ensembl
ENSRNOG00000018020
resolver
genesymbol
Apbb1
resolver
genesymbol_syn
Fe65
resolver
genesymbol_syn
Rir
resolver
uniprot
Q99MK3
resolver
uniprot_entry
APBB1_RAT
resolver
uniprot_sec
Q99MK3
resolver
amino_acid_sequence
MSVPSSLSQSAINANSHGGPALSFPFPLHAAHNQLLNAKLQATAVVPKDLRSAMGEGSVPEPGPANAKWLKEGQNQLRRAATAHRDQNRNVTLTLAEEASQEAETAPLGPKGLMHLYSELELSAHNAANRGLHGSALIINTQGLGPDEGEEKAAGEVEEEDEDEEEEDEEEEDLSSPQGLPEPLENVEVPSGPQVLTDGPREHSKSASLLFGMRNSAASDEDSSWATLSQGSPSYGSPEDTDSFWNPNAFETDSDLPAGWMRVQDTSGTYYWHIPTGTTQWEPPGRASPSQGNSPQEESQLTWTGFAHQEGFEEGEFWKDEPSEEAPMELGLKDPEEGTLPFSAQSLSPEPVPQEEENLPQRNANPGIKCFAVRSLGWVEMTEEELAPGRSSVAVNNCIRQLSYHKNNLHDPMSGGWGEGKDLLLQLEDETLKLVEPQNQTLLHAQPIVSIRVWGVGRDSGRERDFAYVARDKLTQMLKCHVFRCEAPAKNIATSLHEICSKIMSERRNARCLVNGLSLDHSKLVDVPFQVEFPAPKNELVQKFQVYYLGNVPVAKPVGVDVINGALESVLSSSSREQWTPSHVSVAPATLTILHQQTEAVLGECRVRFLSFLAVGRDVHTFAFIMAAGPASFCCHMFWCEPNAASLSEAVQAACMLRYQKCLDARSQTSTSCLPAPPAESVARRVGWTVRRGVQSLWGSLKPKRLGSQTP
uniprot
proteins
function
FUNCTION: Transcription coregulator that can have both coactivator and corepressor functions. Adapter protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precursor protein (APP) intracellular domain. Plays a central role in the response to DNA damage by translocating to the nucleus and inducing apoptosis. May act by specifically recognizing and binding histone H2AX phosphorylated on 'Tyr-142' (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Required for histone H4 acetylation at double-strand breaks (DSBs) (By similarity). Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60, probably explains its transcription activation activity (PubMed:19282473). Functions in association with TSHZ3, SET and HDAC factors as a transcriptional repressor, that inhibits the expression of CASP4. Associates with chromatin in a region surrounding the CASP4 transcriptional start site(s) (By similarity). Involved in hippocampal neurite branching and neuromuscular junction formation, as a result plays a role in spatial memory functioning. Plays a role in the maintenance of lens transparency. May play a role in muscle cell strength (By similarity). Acts as a molecular adapter that functions in neurite outgrowth by activating the RAC1-ARF6 axis upon insulin treatment (By similarity). {ECO:0000250|UniProtKB:O00213, ECO:0000250|UniProtKB:Q9QXJ1, ECO:0000269|PubMed:19282473}.
uniprot
proteins
mass_dalton
77656
uniprot
proteins
mutagenesis
MUTAGEN 655; /note="C->F: Abolishes interaction with APP and impairs the function in DNA repair."; /evidence="ECO:0000269|PubMed:19282473
uniprot
proteins
post_translational_modification
PTM: Polyubiquitination by RNF157 leads to degradation by the proteasome. {ECO:0000250|UniProtKB:O00213}.; PTM: Phosphorylation at Ser-611 by SGK1 promotes its localization to the nucleus (PubMed:18304449). Phosphorylated following nuclear translocation. Phosphorylation at Tyr-547 by ABL1 enhances transcriptional activation activity and reduces the affinity for RASD1/DEXRAS1 (By similarity). Phosphorylated at Ser-460 by PKC upon insulin activation (By similarity). {ECO:0000250|UniProtKB:O00213, ECO:0000269|PubMed:18304449}.; PTM: Acetylation at Lys-205 and Lys-702 by KAT5 promotes its transcription activator activity. {ECO:0000250|UniProtKB:O00213}.
uniprot
proteins
pubmed
18304449
uniprot
proteins
pubmed
1923810
uniprot
proteins
pubmed
19282473
uniprot
proteins
pubmed
19343227
uniprot
proteins
pubmed
7800475
uniprot
proteins
sequence_length
711
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O00213}. Cytoplasm {ECO:0000250|UniProtKB:O00213}. Nucleus {ECO:0000269|PubMed:18304449}. Cell projection, growth cone {ECO:0000269|PubMed:19343227}. Nucleus speckle {ECO:0000250|UniProtKB:O00213}. Note=Colocalizes with TSHZ3 in axonal growth cone (PubMed:19343227). Colocalizes with TSHZ3 in the nucleus. In normal conditions, it mainly localizes to the cytoplasm, while a small fraction is tethered to the cell membrane via its interaction with APP. Following exposure to DNA damaging agents, it is released from cell membrane and translocates to the nucleus. Nuclear translocation is under the regulation of APP. Colocalizes with NEK6 at the nuclear speckles (By similarity). Phosphorylation at Ser-610 by SGK1 promotes its localization to the nucleus (PubMed:18304449). {ECO:0000250|UniProtKB:O00213, ECO:0000269|PubMed:18304449, ECO:0000269|PubMed:19343227}.
uniprot
proteins