Tmem86a
entrez
67893
canonical
uniprot
Q9D8N3
canonical
ensembl
ENSMUSG00000010307
resolver
ensp
ENSMUSP00000010451
resolver
enst
ENSMUST00000010451
resolver
genesymbol
Tmem86a
resolver
uniprot
Q8C6I3
resolver
uniprot_entry
TM86A_MOUSE
resolver
uniprot_sec
Q8C6I3
resolver
amino_acid_sequence
MVSPVTVVKSEGPKLVPFFKATCVYFVLWLPSSSPSWVSALIKCLPIFCLWLFLLAHGVRFLLAHPSASLIFVGLVFSAVGDAFLIWQDHGYFEHGLLMFAVAHILYAAAFGMRPLALRTGLVIGVLSGLCYALLYPGLSGAFTYLVGVYVALISFMGWRAMAGLRLVGAAWRWTELAAGGGALLFILSDLTIALNKFCFPVPYSRALIMSTYYAAQMLIALSAVESREPVGEDYRLSKAD
uniprot
proteins
ec_number
3.3.2.2
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of the vinyl ether bond of choline or ethanolamine lysoplasmalogens, forming fatty aldehyde and glycerophosphocholine or glycerophosphoethanolamine, respectively and is specific for the sn-2-deacylated (lyso) form of plasmalogen (PubMed:35835749, PubMed:36592658). Plays an important role in lysoplasmalogen metabolism in the adipocyte tissue and macrophages (PubMed:35835749, PubMed:36592658). {ECO:0000269|PubMed:35835749, ECO:0000269|PubMed:36592658}.
uniprot
proteins
mass_dalton
26273
uniprot
proteins
mutagenesis
MUTAGEN 82; /note="D->V: Reduced lysoplasmalogenase activity."; /evidence="ECO:0000269|PubMed:35835749"; MUTAGEN 104; /note="H->L: Reduced lysoplasmalogenase activity."; /evidence="ECO:0000269|PubMed:36592658"; MUTAGEN 190; /note="D->V: Reduced lysoplasmalogenase activity."; /evidence="ECO:0000269|PubMed:35835749, ECO:0000269|PubMed:36592658
uniprot
proteins
protein_family
TMEM86 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
35835749
uniprot
proteins
pubmed
36592658
uniprot
proteins
sequence_length
241
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:35835749, ECO:0000269|PubMed:36592658}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 14..30; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 37..59; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 68..87; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 97..113; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 120..136; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 143..159; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 177..195; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 207..225; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins