Hsd3b7
entrez
101502
canonical
uniprot
Q9EQC1
canonical
ensembl
ENSMUSG00000042289
resolver
ensp
ENSMUSP00000036245
resolver
ensp
ENSMUSP00000101879
resolver
ensp
ENSMUSP00000176275
resolver
enst
ENSMUST00000046863
resolver
enst
ENSMUST00000106272
resolver
genesymbol
Hsd3b7
resolver
uniprot
A2RTR5
resolver
uniprot
D3Z3X1
resolver
uniprot_entry
3BHS7_MOUSE
resolver
uniprot_entry
D3Z3X1_MOUSE
resolver
uniprot_sec
A2RTR5
resolver
amino_acid_sequence
MADSAQVPTLVYLVTGGCGFLGEHIVRMLLEREPRLRELRVFDLHLSSWLEELKAGPVQVTAIQGDVTQAHEVAAAMSGSHVVIHTAGLVDVFGKASPKTIHKVNVQGTQNVIDACVQTGTQYLVYTSSMEVVGPNIKGHPFYRGNEDTPYEAVHSHPYPCSKALAEQLVLEANGRKVNGGLPLVTCALRPTGIYGEGHQVMRDFYYQGLRFGGRLFRAVPASVEHGRVYVGNVAWMHILVARELEQRAALMGGQVYFCYDKSPYKSYEDFNMEFLSPCGLRLIGAHPLLPYWLLVLLATLNALLQWLLRPLVLYTPLLNPYTLAMANTTFTVSTNKAQRHFGYKPLFSWEESRTRTIQWVQAMEGSAR
uniprot
proteins
ec_number
1.1.1.-
uniprot
proteins
ec_number
1.1.1.181
uniprot
proteins
function
FUNCTION: The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis (PubMed:11067870). Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells (PubMed:22999953). {ECO:0000269|PubMed:11067870, ECO:0000269|PubMed:22999953}.
uniprot
proteins
mass_dalton
41135
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; steroid biosynthesis. {ECO:0000269|PubMed:11067870}.
uniprot
proteins
protein_family
3-beta-HSD family
uniprot
proteins
pubmed
11067870
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22999953
uniprot
proteins
sequence_length
369
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 289..309; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 312..334; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins