Dsg1b
entrez
225256
canonical
uniprot
Q7TSF1
canonical
ensembl
ENSMUSG00000061928
resolver
ensp
ENSMUSP00000076026
resolver
enst
ENSMUST00000076737
resolver
genesymbol
Dsg1b
resolver
genesymbol_syn
Dsg5
resolver
uniprot
B2RQH0
resolver
uniprot
Q7TQ60
resolver
uniprot_entry
B2RQH0_MOUSE
resolver
uniprot_entry
DSG1B_MOUSE
resolver
uniprot_sec
Q7TQ60
resolver
amino_acid_sequence
MDWHSFRIAALLLTSLVVLEVNSEFQIQVRDHNAKNGTIKWHSIRRQKREWIKFAAACREGEDNSKRNPIAKIHSDCAANQPVTYRISGVGIDQPPYGIFIINQKTGEINITSIVDREVTPFFIIYCRALNAQGQDLENPLELRVRVMDINDNPPVFSMTTFLGQIEENSNANTLVMKLNATDADEPNNLNSMIAFKIIRQEPSDSPMFIINRKTGEIRTMNNFLDREQYSQYSLVVRGSDRDGGADGMSAESECSITILDVNDNIPYLEQSSYDIEIEENALHSQLVQIRVIDLDEEFSDNWKAIIFFISGNEGNWFEIEMNERTNVGTLKVVKPLDYEAMKNLQLSIGVRNVAEFHQSIISQYRLTATMVTVTVLNVIEGSVFRPGSKTFVVDSRMEANHRVGEFVATDLDTGRASTNVRYEMGNNPENLLVVDSRTGIITLRNRVTMEQYQRLNGEYKGTVLSIDDSLQRTCTGTIVIELSGTGWVPGSDGGGSSSGSGGNRDPVTNGYQGTSTVGPQRVTGSGGVTSSGGGSGVNNTPGRQNPLDEPEPEPFDITEDNVHFGPAGIGLLIMGFLVLGLVPFLLICCDCGGAPGGGAGFEPVPECSDGAIHTWAIEGPQPEPHDGITTICVPQMPPGNANVIEYIDNSGVYTNEYCGREMQDLGGGERTTGFELMDGVKTSAAPEICQEYSGTLRRNSMRECRDGGLNMNFMESYFCQKAYAYADEDEGRPSNDCLLIYDIEGVGSPAGSVGCCSFIGEDLDESFLDTLGPKFKKLADISLGKEIDSYPDPDSSWPPQSTEPMCPQSTEPLGSGYPPISPHFGTTTVISENAYPSGPGVQHPLPIPDPLGYGNVTVRESYATSGTLKPSVHFHDNQQASNVVVTERVVGPVPGADLHGMLEIPDLRDGTNVIVTERVIAPGSSLPTSLTIPNPRETSNVVVTERVIQPTSGMIGNLSMTPELSSAQNVIVTERVVSGAGMSGIAGTAGLGGVGGIGSSGLVSTTMGAAGTGLNMGGTATIGHMRSSSDHHFSQTIGSASPNMARSRITKYSTVQYSK
uniprot
proteins
function
FUNCTION: A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion (PubMed:12631242). Mediates the interaction between the desmosome and COP9 signalosome complex (CSN) protein complex (By similarity). As a result of this interaction, promotes keratinocyte differentiation via deneddylation of EGFR resulting in a reduction in EGFR protein stabilization and translocation away from the cell membrane (By similarity). Critical for epidermal integrity and barrier function of the skin (PubMed:30660666). May mediate the inflammatory response in the epidermis (PubMed:34905516). Required for esophageal epithelial barrier integrity and correct intercellular spacing in differentiated esophageal epithelium (By similarity). Required for recovery of epidermal architecture and correct expression of differentiation markers following UVB exposure (By similarity). May also be required for OCLN involvement in tight junctions (PubMed:30660666). {ECO:0000250|UniProtKB:Q02413, ECO:0000269|PubMed:12631242, ECO:0000269|PubMed:30660666, ECO:0000269|PubMed:34905516}.
uniprot
proteins
mass_dalton
114454
uniprot
proteins
post_translational_modification
PTM: (Microbial infection) Proteolytically processed by Staphylococcus aureus serine protease eta. {ECO:0000269|PubMed:12093888}.
uniprot
proteins
pubmed
12093888
uniprot
proteins
pubmed
12631242
uniprot
proteins
pubmed
12787123
uniprot
proteins
pubmed
16170054
uniprot
proteins
pubmed
24220297
uniprot
proteins
pubmed
30660666
uniprot
proteins
pubmed
34905516
uniprot
proteins
sequence_length
1060
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12631242}; Single-pass type I membrane protein {ECO:0000269|PubMed:12631242}. Cell junction, desmosome {ECO:0000269|PubMed:12631242}. Cytoplasm {ECO:0000250|UniProtKB:Q02413}. Nucleus {ECO:0000250|UniProtKB:Q02413}.
uniprot
proteins
transmembrane_region
TRANSMEM 568..588; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins