Mettl9
entrez
59052
canonical
uniprot
Q9EPL4
canonical
ensembl
ENSMUSG00000030876
resolver
ensp
ENSMUSP00000033163
resolver
ensp
ENSMUSP00000147071
resolver
ensp
ENSMUSP00000175097
resolver
ensp
ENSMUSP00000175099
resolver
ensp
ENSMUSP00000175100
resolver
ensp
ENSMUSP00000175102
resolver
ensp
ENSMUSP00000175109
resolver
ensp
ENSMUSP00000175118
resolver
ensp
ENSMUSP00000175122
resolver
enst
ENSMUST00000033163
resolver
genesymbol
Mettl9
resolver
genesymbol_syn
drev
resolver
uniprot
A0JG25
resolver
uniprot
Q3TDX0
resolver
uniprot
Q641L4
resolver
uniprot
Q8R567
resolver
uniprot
Q9EPL3
resolver
uniprot
Q9JJ88
resolver
uniprot_entry
METL9_MOUSE
resolver
uniprot_sec
A0JG25
resolver
uniprot_sec
Q3TDX0
resolver
uniprot_sec
Q641L4
resolver
uniprot_sec
Q8R567
resolver
uniprot_sec
Q9EPL3
resolver
uniprot_sec
Q9JJ88
resolver
amino_acid_sequence
MRLLAGWLCLSLASVWLARRMWTLRSPLSRSLYVNMTSGPGGPAAAAGGGKDTHQWYVCNREKLCESLQSVFVQSYLDQGTQIFLNNSIEKSGWLFIQLYHSFVSSVFSLFMSRTSINGLLGRGSMFVFSPDQFQRLLRINPDWKTHRLLDLGAGDGEVTKIMSPHFEEIYATELSETMIWQLQKKKYRVLGINEWQNTGFQYDVISCLNLLDRCDQPLTLLKDIRSVLEPTQGRVILALVLPFHPYVENVGGKWEKPSEILEIKGQNWEEQVNSLPEVFRKAGFVVEAFTRLPYLCEGDMYNDYYVLDDAVFVLRPV
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Protein-histidine N-methyltransferase that specifically catalyzes 1-methylhistidine (pros-methylhistidine) methylation of target proteins (PubMed:33563959, PubMed:34218407). Specifically methylates the second His of proteins with a His-x-His (HxH) motif (where 'x' is preferably a small amino acid), while exploiting the first one as a recognition signature (PubMed:33563959, PubMed:34218407). Catalyzes methylation of target proteins such as S100A9, NDUFB3, SLC39A5, SLC39A7, ARMC6 and DNAJB12; 1-methylhistidine modification may affect the binding of zinc and other metals to its target proteins (PubMed:33563959, PubMed:34218407). Constitutes the main methyltransferase for the 1-methylhistidine modification in cell (PubMed:33563959). {ECO:0000269|PubMed:33563959, ECO:0000269|PubMed:34218407}.
uniprot
proteins
mass_dalton
36426
uniprot
proteins
mutagenesis
MUTAGEN 151; /note="D->A: Abolished protein-histidine N-methyltransferase activity."; /evidence="ECO:0000269|PubMed:34218407"; MUTAGEN 153; /note="G->R: Abolished protein-histidine N-methyltransferase activity."; /evidence="ECO:0000269|PubMed:34218407"; MUTAGEN 155; /note="G->R: Abolished protein-histidine N-methyltransferase activity."; /evidence="ECO:0000269|PubMed:34218407"; MUTAGEN 175; /note="L->A: Reduced protein-histidine N-methyltransferase activity."; /evidence="ECO:0000269|PubMed:34218407"; MUTAGEN 180; /note="I->A: Reduced protein-histidine N-methyltransferase activity."; /evidence="ECO:0000269|PubMed:34218407"; MUTAGEN 204; /note="D->A: Abolished protein-histidine N-methyltransferase activity."; /evidence="ECO:0000269|PubMed:34218407
uniprot
proteins
protein_family
METTL9 family
uniprot
proteins
pubmed
11132146
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
33563959
uniprot
proteins
pubmed
34218407
uniprot
proteins
sequence_length
318
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9H1A3}. Mitochondrion {ECO:0000250|UniProtKB:Q9H1A3}. Note=Colocalizes with membranous compartments such as the endoplasmic reticulum and mitochondria. {ECO:0000250|UniProtKB:Q9H1A3}.
uniprot
proteins