IBTK
entrez
25998
canonical
uniprot
Q9P2D0
canonical
ensembl
ENSG00000005700
resolver
ensembl
ENSG00000283068
resolver
ensp
ENSP00000305721
resolver
ensp
ENSP00000426405
resolver
ensp
ENSP00000489548
resolver
enst
ENST00000510291
resolver
enst
ENST00000635384
resolver
genesymbol
IBTK
resolver
genesymbol_syn
BTKI
resolver
genesymbol_syn
KIAA1417
resolver
hgnc
HGNC:17853
resolver
uniprot
B7ZLE0
resolver
uniprot
E7EPI0
resolver
uniprot
Q2QKU2
resolver
uniprot
Q2QKU3
resolver
uniprot
Q2QKU4
resolver
uniprot
Q5TFD7
resolver
uniprot
Q5TFD9
resolver
uniprot
Q8IUQ9
resolver
uniprot
Q8IUY7
resolver
uniprot
Q8TAI4
resolver
uniprot
Q9HBI8
resolver
uniprot
Q9Y3T8
resolver
uniprot_entry
B7ZLE0_HUMAN
resolver
uniprot_entry
E7EPI0_HUMAN
resolver
uniprot_entry
IBTK_HUMAN
resolver
uniprot_sec
Q2QKU2
resolver
uniprot_sec
Q2QKU3
resolver
uniprot_sec
Q2QKU4
resolver
uniprot_sec
Q5TFD7
resolver
uniprot_sec
Q5TFD9
resolver
uniprot_sec
Q8IUQ9
resolver
uniprot_sec
Q8IUY7
resolver
uniprot_sec
Q8TAI4
resolver
uniprot_sec
Q9HBI8
resolver
uniprot_sec
Q9Y3T8
resolver
amino_acid_sequence
MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVSSCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGLSALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGDIYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCWRSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSNLHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPAVSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTSEFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEYQGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRMLQTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEFPCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQNVDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIGLNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFLKEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSSTGLLKSGKTNSVESLPELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPWEKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPKSHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVSSKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVRCSTHGTPGPEGNHISDLPLLDSPNPWLSSSVTAPSMVAPVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLLVFYEAFGNPEEFVIVERTPQGPLAVPMWNKHGC
uniprot
proteins
function
FUNCTION: Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription. {ECO:0000269|PubMed:11577348}.
uniprot
proteins
mass_dalton
150528
uniprot
proteins
pubmed
10718198
uniprot
proteins
pubmed
11577348
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18596081
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
1353
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Note=Translocates to the plasma membrane upon IgM stimulation.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus.
uniprot
proteins