Angpt2
entrez
89805
canonical
uniprot
O35462
canonical
ensembl
ENSRNOG00000016696
resolver
ensembl
ENSRNOG00055008284
resolver
ensembl
ENSRNOG00060021324
resolver
ensembl
ENSRNOG00065009041
resolver
ensp
ENSRNOP00000022774
resolver
ensp
ENSRNOP00055011224
resolver
ensp
ENSRNOP00060030466
resolver
ensp
ENSRNOP00065010818
resolver
enst
ENSRNOT00000022774
resolver
enst
ENSRNOT00055014001
resolver
enst
ENSRNOT00060036958
resolver
enst
ENSRNOT00065014451
resolver
genesymbol
Angpt2
resolver
genesymbol_syn
Agpt2
resolver
uniprot
B1WBY0
resolver
uniprot
Q548N5
resolver
uniprot_entry
ANGP2_RAT
resolver
uniprot_sec
B1WBY0
resolver
uniprot_sec
Q548N5
resolver
amino_acid_sequence
MWQIVFLTFGCDLVLASAYNNFRKSVDSTGRRQYQVQNGPCSYTFLLPETDSCRSSSSPYMSNAVQRDAPLDYDDSVQRLQVLENILENNTQWLMKLENYIQDNMKKEMVEIQQNVVQNQTAVMIEIGTSLLNQTAAQTRKLTDVEAQVLNQTTRLELQLLQHSISTNKLEKQILDQTSEINKLQDKNSFLEKKVLDMEDKHSVQLQSMKEQKDQLQVLVSKQSSVIDELEKKLVTATVNNSVLQKQQHDLMETVNSLLTMMSSPDYKSSVAVPKEEKTTFRDCAEIFKSGLTTSGIYTLTFPNSTEEVKAYCDMDMGGGGWTVIQHREDGSVDFQRTWKEYKEGFGSPLGEYWLGNEFVSQLTSGHRYVLKIQLKDWEGSEAHSLYEHFYLSGEESNYRIHLTGLTGTAGKISSISQPGSDFSTKDSDNDKCICKCSQMLTGGWWFDACGPSNLNGQYYPQKQNTNKFNGIKWYYWKGSGYSLKATTMMIRPADF
uniprot
proteins
function
FUNCTION: Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling (By similarity). Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression (By similarity). In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity). Involved in the regulation of lymphangiogenesis (By similarity). {ECO:0000250|UniProtKB:O15123}.
uniprot
proteins
mass_dalton
56518
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9776732
uniprot
proteins
sequence_length
496
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:O15123}.
uniprot
proteins