Gbp4
entrez
17472
canonical
uniprot
A4UUI3
canonical
ensembl
ENSMUSG00000079363
resolver
ensp
ENSMUSP00000098522
resolver
ensp
ENSMUSP00000364833
resolver
genesymbol
Gbp4
resolver
uniprot
A0A0G2JDT5
resolver
uniprot
A0A0G2JEJ5
resolver
uniprot
A0A0G2JGT4
resolver
uniprot
B9EJ74
resolver
uniprot
Q61594
resolver
uniprot_entry
GBP4_MOUSE
resolver
uniprot_sec
A0A0G2JDT5
resolver
uniprot_sec
A0A0G2JEJ5
resolver
uniprot_sec
A0A0G2JGT4
resolver
uniprot_sec
B9EJ74
resolver
uniprot_sec
Q61594
resolver
amino_acid_sequence
MTQPQMAPICLVENHNEQLSVNQEAIEILDKISQPVVVVAIVGWSHTGKSYLMNCLAGQNHVSGTLPTSQRFPSGLHRAVSDQGHLDVVHAPPHQARALVLLDTEGLGDVEKGDPKNDLWIFALSVLLSSTFVYNSMNTINHQALEQLHYVTELTELIRAKSSPNPHGIKNSTEFVSFFPDFVWTVRDFMLELKLNGEDITSDEYLENALKLIPGNNPRIQASNSARECIRRFFPNRKCFVFEWPTHDIELIKQLETISEDQLDPTFKESAMAFASYIFTYAKIKTLREGIKVTGNGLGTLVTTYVDAINSGAVPCLDDAVTTLAQRENSVAVQKAASHYSEQMAQRLSLPTDTIQELLDVHAACEKEAMAVFMEHSFKDENQQFLKKLVELLREKNGLFLLKNEEASDKYCQEELDRLSKDLMDNISTFSVPGGHRLYMDMREKIEHDYWQVPRKGVKASEVFQNFLQSQAIIESSILQADTALTAGQKAIAEKHTKKEAAEKEQDLLRQKQKEHQEYMEAQEKRNKENLEQLRRKLEQEREQLIKDHNMMLEKLTKEQKTFREEGYKTQAEELRREIHQLGHNIKEMKQNGDSLVESILRSWFSFISPPSESEKAISSVLSLLRKKDRL
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (PubMed:18025219). Negatively regulates the antiviral response by inhibiting activation of IRF7 transcription factor (PubMed:22095711). {ECO:0000269|PubMed:18025219, ECO:0000269|PubMed:22095711}.
uniprot
proteins
mass_dalton
72042
uniprot
proteins
protein_family
GB1 subfamily
uniprot
proteins
protein_family
GB1/RHD3 GTPase family
uniprot
proteins
protein_family
TRAFAC class dynamin-like GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1753106
uniprot
proteins
pubmed
18025219
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
22095711
uniprot
proteins
sequence_length
631
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q96PP9}. Cytoplasm {ECO:0000250|UniProtKB:Q96PP9}. Nucleus {ECO:0000250|UniProtKB:Q96PP9}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q96PP9}. Note=Heterodimers with GBP1, GBP2 and GBP5 localize in the compartment of the prenylated GBPs: with GBP1 in a vesicle-like compartment, with GBP2, around the nucleus and with GBP5, at the Golgi apparatus. {ECO:0000250|UniProtKB:Q96PP9}.
uniprot
proteins