Cxadr
entrez
13052
canonical
uniprot
P97792
canonical
ensembl
ENSMUSG00000022865
resolver
ensp
ENSMUSP00000023572
resolver
ensp
ENSMUSP00000109867
resolver
ensp
ENSMUSP00000156281
resolver
genesymbol
Cxadr
resolver
genesymbol_syn
Car
resolver
uniprot
O09052
resolver
uniprot
Q3ULD0
resolver
uniprot
Q91W66
resolver
uniprot
Q99KG0
resolver
uniprot
Q9DBJ8
resolver
uniprot_entry
CXAR_MOUSE
resolver
uniprot_sec
O09052
resolver
uniprot_sec
Q3ULD0
resolver
uniprot_sec
Q91W66
resolver
uniprot_sec
Q99KG0
resolver
uniprot_sec
Q9DBJ8
resolver
amino_acid_sequence
MARLLCFVLLCGIADFTSGLSITTPEQRIEKAKGETAYLPCKFTLSPEDQGPLDIEWLISPSDNQIVDQVIILYSGDKIYDNYYPDLKGRVHFTSNDVKSGDASINVTNLQLSDIGTYQCKVKKAPGVANKKFLLTVLVKPSGTRCFVDGSEEIGNDFKLKCEPKEGSLPLQFEWQKLSDSQTMPTPWLAEMTSPVISVKNASSEYSGTYSCTVQNRVGSDQCMLRLDVVPPSNRAGTIAGAVIGTLLALVLIGAILFCCHRKRREEKYEKEVHHDIREDVPPPKSRTSTARSYIGSNHSSLGSMSPSNMEGYSKTQYNQVPSEDFERAPQSPTLAPAKVAAPNLSRMGAVPVMIPAQSKDGSIV
uniprot
proteins
function
FUNCTION: Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. {ECO:0000269|PubMed:10814828, ECO:0000269|PubMed:20813954, ECO:0000269|PubMed:9036860, ECO:0000269|PubMed:9420240}.
uniprot
proteins
mass_dalton
39948
uniprot
proteins
post_translational_modification
PTM: Palmitoylated on Cys-259 and/or Cys-260; required for proper localization to the plasma membrane. {ECO:0000250}.
uniprot
proteins
pubmed
10814828
uniprot
proteins
pubmed
12763576
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15533241
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
20181587
uniprot
proteins
pubmed
20813954
uniprot
proteins
pubmed
20813955
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9036860
uniprot
proteins
pubmed
9096397
uniprot
proteins
pubmed
9420240
uniprot
proteins
sequence_length
365
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:15533241}; Single-pass type I membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:P78310}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, tight junction {ECO:0000250|UniProtKB:P78310}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P78310}. Note=In epithelial cells localizes to the apical junction complex composed of tight and adherens junctions. In airway epithelial cells localized to basolateral membrane but not to apical surface. {ECO:0000250|UniProtKB:P78310}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 238..258; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins