Or4c12
entrez
258338
canonical
uniprot
Q8VEZ1
canonical
ensembl
ENSMUSG00000068806
resolver
ensp
ENSMUSP00000088194
resolver
genesymbol
Or4c12
resolver
genesymbol_syn
Olfr1259
resolver
uniprot_entry
OR4CC_MOUSE
resolver
amino_acid_sequence
MENKRNVTEFILIGLTQNPQMQKVVFVTFLVLYMTTISGNLLIVVTIINSQALNSPMYFFLSHLSLIDTIYTSSSAPKLIADSLQENKVISFNGCMAQVYAEHIFGATEIILLTVMAYDRYVAICKPLHYMTIMSHKLCILLVGVAWTGGFLHATIQILFTVWLPFCGPNIIDHFMCDLYPLLELVCMDTHILGLFVAANSGFICLFNFLLLMGSYVIILRSLKNYSLEGRRKALSTCVSHITVVVLFFIPCIFVYLRPVTTLPLDKGVAVFYTMVAPMLNPLIYTLRNAEVKNAIKKLWRKKVTSDSN
uniprot
proteins
function
FUNCTION: Acts as a receptor for R-(-)-carvone in pancreatic cells, initiating signaling pathways involving GNAS, elevated intracellular Ca(2+), and increased cAMP levels. Upon activation, promotes glucose-stimulated insulin secretion. {ECO:0000269|PubMed:40157529}.
uniprot
proteins
mass_dalton
34863
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11802173
uniprot
proteins
pubmed
11875048
uniprot
proteins
pubmed
14611657
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21750661
uniprot
proteins
pubmed
40157529
uniprot
proteins
sequence_length
309
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 24..44; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 96..116; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 140..160; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 192..212; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 237..257; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 267..287; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins