Cd8b
entrez
12526
canonical
uniprot
P10300
canonical
ensembl
ENSMUSG00000053044
resolver
ensp
ENSMUSP00000070131
resolver
enst
ENSMUST00000065248
resolver
genesymbol
Cd8b
resolver
genesymbol
Cd8b1
resolver
genesymbol_syn
Cd8b1
resolver
genesymbol_syn
Ly-3
resolver
genesymbol_syn
Lyt-3
resolver
genesymbol_syn
Lyt3
resolver
uniprot
Q31127
resolver
uniprot
Q3TEK8
resolver
uniprot
Q60966
resolver
uniprot
Q61811
resolver
uniprot_entry
CD8B_MOUSE
resolver
uniprot_entry
Q3TEK8_MOUSE
resolver
uniprot_sec
Q31127
resolver
uniprot_sec
Q60966
resolver
uniprot_sec
Q61811
resolver
amino_acid_sequence
MQPWLWLVFSMKLAALWSSSALIQTPSSLLVQTNHTAKMSCEVKSISKLTSIYWLRERQDPKDKYFEFLASWSSSKGVLYGESVDKKRNIILESSDSRRPFLSIMNVKPEDSDFYFCATVGSPKMVFGTGTKLTVVDVLPTTAPTKKTTLKMKKKKQCPFPHPETQKGLTCSLTTLSLLVVCILLLLAFLGVAVYFYCVRRRARIHFMKQFHK
uniprot
proteins
function
FUNCTION: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, plays a critical role in thymic selection of CD8+ T-cells. {ECO:0000250|UniProtKB:P10966, ECO:0000269|PubMed:12215456, ECO:0000269|PubMed:8064243, ECO:0000269|PubMed:8108731}.
uniprot
proteins
mass_dalton
24288
uniprot
proteins
post_translational_modification
PTM: Palmitoylated at the cytoplasmic tail and thereby targets the heterodimer CD8A/CD8B to lipid rafts unlike CD8A homodimers. {ECO:0000250|UniProtKB:P10966}.
uniprot
proteins
pubmed
12215456
uniprot
proteins
pubmed
16356863
uniprot
proteins
pubmed
18929574
uniprot
proteins
pubmed
19088062
uniprot
proteins
pubmed
2452747
uniprot
proteins
pubmed
2784466
uniprot
proteins
pubmed
3035575
uniprot
proteins
pubmed
3169881
uniprot
proteins
pubmed
3258885
uniprot
proteins
pubmed
3498943
uniprot
proteins
pubmed
8064243
uniprot
proteins
pubmed
8108731
uniprot
proteins
pubmed
8537123
uniprot
proteins
sequence_length
213
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P10966}; Single-pass type I membrane protein. Note=Requires the partner CD8A for efficient cell surface expression. The heterodimer CD8A/CD8B localizes to lipid rafts due to CD8B cytoplasmic tail palmitoylation. {ECO:0000250|UniProtKB:P10966}.
uniprot
proteins
transmembrane_region
TRANSMEM 176..196; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins