Sult2b1
entrez
54200
canonical
uniprot
O35400
canonical
ensembl
ENSMUSG00000003271
resolver
ensp
ENSMUSP00000075005
resolver
ensp
ENSMUSP00000147374
resolver
ensp
ENSMUSP00000148064
resolver
enst
ENSMUST00000210754
resolver
genesymbol
Sult2b1
resolver
genesymbol_syn
Sult2b
resolver
uniprot
A0A1B0GST5
resolver
uniprot
Q8K472
resolver
uniprot
Q91V03
resolver
uniprot_entry
A0A1B0GST5_MOUSE
resolver
uniprot_entry
ST2B1_MOUSE
resolver
uniprot_sec
Q8K472
resolver
uniprot_sec
Q91V03
resolver
amino_acid_sequence
MDGPQPRALWSSSEKNVSEMSWNFGGEYFRYKGIPFPVGMYSPESLSLAENTSNVRDDDIFIVTYPKSGTNWMIEIVCLILKDGDPSWIRSEPIWQRAPWCETIISAFNVLDRPSPRIMSSHLPIELFTKAFFSSKAKVIYVGRNPRDVVVSLYYYSKIAGQLKDPGTPDQFLQNFLKGEVQFGSWFDHIKGWIRMQNQENFLFITYEELQQDLRGSVQRICEFLGRPLGEEALSSVVAHSAFAAMKANTMSNYSLLPASLLDHRQGEFLRKGISGDWKNHFTVAQSEAFDSVYREQMHGVQRFPWDTSEEDSSPDGQPDPEPSPSPASDDPNPGSSQ
uniprot
proteins
ec_number
2.8.2.2
uniprot
proteins
function
FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Preferentially sulfonates cholesterol (PubMed:12639899). Catalyzes sulfation of the 3beta-hydroxyl groups of steroids, such as, pregnenolone and dehydroepiandrosterone (DHEA). Cholesterol sulfation is approximately 10-fold higher than for pregnenolone and 20-fold higher than for DHEA (PubMed:12639899). Plays a role in epidermal cholesterol metabolism and in the regulation of epidermal proliferation and differentiation (By similarity). {ECO:0000250|UniProtKB:O00204, ECO:0000269|PubMed:12639899}.; FUNCTION: [Isoform 2]: Strongly sulfonates pregnenolone, however is capable to sulfonate cholesterol with a high degree of efficiency. DHEA is a relatively poor substrate. {ECO:0000269|PubMed:12639899}.
uniprot
proteins
mass_dalton
38347
uniprot
proteins
protein_family
Sulfotransferase 1 family
uniprot
proteins
pubmed
12639899
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9647753
uniprot
proteins
sequence_length
338
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O00204}. Microsome {ECO:0000250|UniProtKB:O00204}. Nucleus {ECO:0000250|UniProtKB:O00204}.
uniprot
proteins