TXNRD1
entrez
7296
canonical
uniprot
Q16881
canonical
ensembl
ENSG00000198431
resolver
ensp
ENSP00000421934
resolver
ensp
ENSP00000432812
resolver
ensp
ENSP00000433425
resolver
ensp
ENSP00000434516
resolver
ensp
ENSP00000434919
resolver
ensp
ENSP00000435123
resolver
ensp
ENSP00000435929
resolver
enst
ENST00000503506
resolver
enst
ENST00000524698
resolver
enst
ENST00000525566
resolver
enst
ENST00000526390
resolver
enst
ENST00000526691
resolver
enst
ENST00000526950
resolver
enst
ENST00000529546
resolver
genesymbol
TXNRD1
resolver
genesymbol_syn
GRIM12
resolver
genesymbol_syn
KDRF
resolver
hgnc
HGNC:12437
resolver
uniprot
B7Z1F4
resolver
uniprot
B7Z2S5
resolver
uniprot
B7Z3Y8
resolver
uniprot
B7Z904
resolver
uniprot
E9PMY9
resolver
uniprot
F5H780
resolver
uniprot
Q6FI31
resolver
uniprot
Q6VB40
resolver
uniprot
Q6VB41
resolver
uniprot
Q6VB42
resolver
uniprot
Q6VBP2
resolver
uniprot
Q6VBP3
resolver
uniprot
Q6VBP4
resolver
uniprot
Q6VBP5
resolver
uniprot
Q6VBP9
resolver
uniprot
Q6VBQ0
resolver
uniprot
Q6YNQ1
resolver
uniprot
Q76P53
resolver
uniprot
Q7LA96
resolver
uniprot
Q8WVC8
resolver
uniprot
Q99475
resolver
uniprot
Q9UES8
resolver
uniprot
Q9UH79
resolver
uniprot_entry
B7Z2S5_HUMAN
resolver
uniprot_entry
TRXR1_HUMAN
resolver
uniprot_sec
B7Z1F4
resolver
uniprot_sec
B7Z3Y8
resolver
uniprot_sec
B7Z904
resolver
uniprot_sec
E9PMY9
resolver
uniprot_sec
F5H780
resolver
uniprot_sec
Q6FI31
resolver
uniprot_sec
Q6VB40
resolver
uniprot_sec
Q6VB41
resolver
uniprot_sec
Q6VB42
resolver
uniprot_sec
Q6VBP2
resolver
uniprot_sec
Q6VBP3
resolver
uniprot_sec
Q6VBP4
resolver
uniprot_sec
Q6VBP5
resolver
uniprot_sec
Q6VBP9
resolver
uniprot_sec
Q6VBQ0
resolver
uniprot_sec
Q6YNQ1
resolver
uniprot_sec
Q76P53
resolver
uniprot_sec
Q7LA96
resolver
uniprot_sec
Q8WVC8
resolver
uniprot_sec
Q99475
resolver
uniprot_sec
Q9UES8
resolver
uniprot_sec
Q9UH79
resolver
amino_acid_sequence
MGCAEGKAVAAAAPTELQTKGKNGDGRRRSAKDHHPGKTLPENPAGFTSTATADSRALLQAYIDGHSVVIFSRSTCTRCTEVKKLFKSLCVPYFVLELDQTEDGRALEGTLSELAAETDLPVVFVKQRKIGGHGPTLKAYQEGRLQKLLKMNGPEDLPKSYDYDLIIIGGGSGGLAAAKEAAQYGKKVMVLDFVTPTPLGTRWGLGGTCVNVGCIPKKLMHQAALLGQALQDSRNYGWKVEETVKHDWDRMIEAVQNHIGSLNWGYRVALREKKVVYENAYGQFIGPHRIKATNNKGKEKIYSAERFLIATGERPRYLGIPGDKEYCISSDDLFSLPYCPGKTLVVGASYVALECAGFLAGIGLDVTVMVRSILLRGFDQDMANKIGEHMEEHGIKFIRQFVPIKVEQIEAGTPGRLRVVAQSTNSEEIIEGEYNTVMLAIGRDACTRKIGLETVGVKINEKTGKIPVTDEEQTNVPYIYAIGDILEDKVELTPVAIQAGRLLAQRLYAGSTVKCDYENVPTTVFTPLEYGACGLSEEKAVEKFGEENIEVYHSYFWPLEWTIPSRDNNKCYAKIICNTKDNERVVGFHVLGPNAGEVTQGFAAALKCGLTKKQLDSTIGIHPVCAEVFTTLSVTKRSGASILQAGCUG
uniprot
proteins
ec_number
1.11.1.2
uniprot
proteins
ec_number
1.8.1.9
uniprot
proteins
function
FUNCTION: Reduces disulfide protein thioredoxin (Trx) to its dithiol-containing form (PubMed:8577704). Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. A selenocysteine residue at the C-terminal active site is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2) (PubMed:10849437). {ECO:0000269|PubMed:10849437, ECO:0000269|PubMed:8577704, ECO:0000305|PubMed:17512005}.; FUNCTION: [Isoform 1]: Induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. {ECO:0000269|PubMed:18042542, ECO:0000269|PubMed:8577704}.; FUNCTION: [Isoform 4]: Enhances the transcriptional activity of estrogen receptors ESR1 and ESR2. {ECO:0000269|PubMed:15199063}.; FUNCTION: [Isoform 5]: Enhances the transcriptional activity of the estrogen receptor ESR2 only (PubMed:15199063). Mediates cell death induced by a combination of interferon-beta and retinoic acid (PubMed:9774665). {ECO:0000269|PubMed:15199063, ECO:0000269|PubMed:9774665}.
uniprot
proteins
mass_dalton
70906
uniprot
proteins
post_translational_modification
PTM: [Isoform 5]: The N-terminus is blocked.; PTM: ISGylated. {ECO:0000305|PubMed:16815975}.
uniprot
proteins
protein_family
Class-I pyridine nucleotide-disulfide oxidoreductase family
uniprot
proteins
pubmed
10849437
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14980707
uniprot
proteins
pubmed
15199063
uniprot
proteins
pubmed
15379556
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
16815975
uniprot
proteins
pubmed
17512005
uniprot
proteins
pubmed
18042542
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
7589432
uniprot
proteins
pubmed
8577704
uniprot
proteins
pubmed
8650234
uniprot
proteins
pubmed
8999974
uniprot
proteins
pubmed
9774665
uniprot
proteins
sequence_length
649
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:18042542}.; SUBCELLULAR LOCATION: [Isoform 4]: Cytoplasm {ECO:0000269|PubMed:15199063}. Nucleus {ECO:0000269|PubMed:15199063}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:15199063}.
uniprot
proteins