PPP1R14C
entrez
81706
canonical
uniprot
Q8TAE6
canonical
ensembl
ENSG00000198729
resolver
ensp
ENSP00000355260
resolver
enst
ENST00000361131
resolver
genesymbol
PPP1R14C
resolver
genesymbol_syn
KEPI
resolver
hgnc
HGNC:14952
resolver
uniprot
Q5VY83
resolver
uniprot
Q96BB1
resolver
uniprot
Q9H277
resolver
uniprot_entry
PP14C_HUMAN
resolver
uniprot_sec
Q5VY83
resolver
uniprot_sec
Q96BB1
resolver
uniprot_sec
Q9H277
resolver
amino_acid_sequence
MSVATGSSETAGGASGGGARVFFQSPRGGAGGSPGSSSGSGSSREDSAPVATAAAAGQVQQQQQRRHQQGKVTVKYDRKELRKRLVLEEWIVEQLGQLYGCEEEEMPEVEIDIDDLLDADSDEERASKLQEALVDCYKPTEEFIKELLSRIRGMRKLSPPQKKSV
uniprot
proteins
function
FUNCTION: Inhibitor of the PP1 regulatory subunit PPP1CA.
uniprot
proteins
mass_dalton
17843
uniprot
proteins
post_translational_modification
PTM: Has over 600-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction (By similarity). The main inhibitory site appears to be Thr-73. {ECO:0000250, ECO:0000269|PubMed:12804574}.
uniprot
proteins
protein_family
PP1 inhibitor family
uniprot
proteins
pubmed
11812771
uniprot
proteins
pubmed
12747765
uniprot
proteins
pubmed
12804574
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
165
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
uniprot
proteins