Krt25
entrez
70810
canonical
uniprot
Q8VCW2
canonical
ensembl
ENSMUSG00000035831
resolver
ensp
ENSMUSP00000048439
resolver
enst
ENSMUST00000038004
resolver
genesymbol
Krt25
resolver
uniprot_entry
K1C25_MOUSE
resolver
amino_acid_sequence
MSLRLSSGSRRSYARPSTGSLRGASFGAGNACGVAGIGSGFSCAFGGSSTGGNTGVANSCAGFTVNEGGLLSGNEKVTMQNLNDRLASYLDNVQALQEANADLEQKIKGWYEKFGPGSCRGLDHDYSRYFPIIDDLKNQIITSTTSNANAVLQIDNARLTADDFRLKYENELALHQSVEADVNGLRRVLDEITLCRTDLEIQYETLSEELTYLKKNHKEEMQALQCAAGGNVNVEMNAAPGVDLTVLLNNMRAEYEALAEQNRRDAEAWFQEKSASLQQQITEDVGATTSARNELTEMKRTLQTLEIELQSLLATKHSLECSLTETEGNYCTQLAQIQAQISALEEQLHQVRTETEGQKLEYEQLLNVKAHLEKEIETYCLLIGGDEGACKSSSYKSKDYGSGNAGNQIKDPVKAIVVKKVLEEVDQRSKILTTRLHSLEEKSQSN
uniprot
proteins
function
FUNCTION: Essential for the proper assembly of type I and type II keratin protein complexes and formation of keratin intermediate filaments in the inner root sheath (irs) (PubMed:14996088, PubMed:17920809). Plays a role in the cytoskeleton organization (By similarity). {ECO:0000250|UniProtKB:Q7Z3Z0, ECO:0000269|PubMed:14996088, ECO:0000269|PubMed:17920809}.
uniprot
proteins
mass_dalton
48921
uniprot
proteins
mutagenesis
MUTAGEN 379; /note="Y->N: In Rex mutant M100573; mice exhibit curly hair and vibrissae. The diameter of the hair shaft is irregular due to morphological abnormalities in all three layers of the irs."; /evidence="ECO:0000269|PubMed:17920809"; MUTAGEN 381; /note="L->P: In Rex mutant Re; mice exhibit curly hair and vibrissae. The diameter of the hair shaft is irregular due to morphological abnormalities in all three layers of the irs."; /evidence="ECO:0000269|PubMed:17920809
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
14996088
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17920809
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
446
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14996088}.
uniprot
proteins