CPA4
entrez
51200
canonical
uniprot
Q9UI42
canonical
ensembl
ENSG00000128510
resolver
ensp
ENSP00000222482
resolver
ensp
ENSP00000412947
resolver
ensp
ENSP00000419660
resolver
enst
ENST00000493259
resolver
genesymbol
CPA4
resolver
genesymbol_syn
CPA3
resolver
hgnc
HGNC:15740
resolver
uniprot
A4D1M3
resolver
uniprot
B7Z576
resolver
uniprot
B7Z5J4
resolver
uniprot
F6WHN5
resolver
uniprot
Q86UY9
resolver
uniprot_entry
A4D1M3_HUMAN
resolver
uniprot_entry
B7Z5J4_HUMAN
resolver
uniprot_entry
CBPA4_HUMAN
resolver
uniprot_entry
F6WHN5_HUMAN
resolver
uniprot_sec
B7Z576
resolver
uniprot_sec
Q86UY9
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by interaction with the metallocarboxypeptidase inhibitor (MCPI) from N.versicolor that binds to the catalytic zinc ion (PubMed:22294694). Also inhibited by interaction with the S.magnifica carboxypeptidase inhibitor SmCI that penetrates the active site groove and inhibits activity by emulating a C-terminal substrate (PubMed:23746805). Additionally inhibited by a carboxypeptidase inhibitor from H.medicinalis (leech) and R.bursa (tick) (PubMed:20385563). {ECO:0000269|PubMed:20385563, ECO:0000269|PubMed:22294694, ECO:0000269|PubMed:23746805}.
uniprot
proteins
amino_acid_sequence
MRWILFIGALIGSSICGQEKFFGDQVLRINVRNGDEISKLSQLVNSNNLKLNFWKSPSSFNRPVDVLVPSVSLQAFKSFLRSQGLEYAVTIEDLQALLDNEDDEMQHNEGQERSSNNFNYGAYHSLEAIYHEMDNIAADFPDLARRVKIGHSFENRPMYVLKFSTGKGVRRPAVWLNAGIHSREWISQATAIWTARKIVSDYQRDPAITSILEKMDIFLLPVANPDGYVYTQTQNRLWRKTRSRNPGSSCIGADPNRNWNASFAGKGASDNPCSEVYHGPHANSEVEVKSVVDFIQKHGNFKGFIDLHSYSQLLMYPYGYSVKKAPDAEELDKVARLAAKALASVSGTEYQVGPTCTTVYPASGSSIDWAYDNGIKFAFTFELRDTGTYGFLLPANQIIPTAEETWLGLKTIMEHVRDNLY
uniprot
proteins
ec_number
3.4.17.-
uniprot
proteins
function
FUNCTION: Metalloprotease that cleaves hydrophobic C-terminal residues with a preference for -Phe, -Leu, -Ile, -Met, -Tyr and -Val (PubMed:20385563). May function in peptide hormone and/or neuropeptide catabolism (PubMed:20385563). {ECO:0000269|PubMed:20385563}.
uniprot
proteins
mass_dalton
47351
uniprot
proteins
protein_family
Peptidase M14 family
uniprot
proteins
pubmed
10383164
uniprot
proteins
pubmed
12552318
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15738388
uniprot
proteins
pubmed
16091843
uniprot
proteins
pubmed
17506531
uniprot
proteins
pubmed
20385563
uniprot
proteins
pubmed
22294694
uniprot
proteins
pubmed
23746805
uniprot
proteins
sequence_length
421
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20385563}.
uniprot
proteins