Abhd5
entrez
316122
canonical
uniprot
Q6QA69
canonical
ensembl
ENSRNOG00000000221
resolver
ensembl
ENSRNOG00055002210
resolver
ensembl
ENSRNOG00060017885
resolver
ensembl
ENSRNOG00065000577
resolver
ensp
ENSRNOP00000000239
resolver
ensp
ENSRNOP00055002620
resolver
ensp
ENSRNOP00060024905
resolver
ensp
ENSRNOP00065000652
resolver
enst
ENSRNOT00000000239
resolver
enst
ENSRNOT00055003514
resolver
enst
ENSRNOT00060030757
resolver
enst
ENSRNOT00065000815
resolver
genesymbol
Abhd5
resolver
uniprot_entry
ABHD5_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Acyltransferase activity is inhibited by detergents such as Triton X-100 and 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate (CHAPS). Acyltransferase activity is inhibited by the presence of magnesium and calcium. {ECO:0000250|UniProtKB:Q9DBL9}.
uniprot
proteins
amino_acid_sequence
MKAMAAEEEVDSADAGGGSGWLTGWLPTWCPTSTSHLKEAEEKMLKCVPCTYKKEPVRISNGNSIWTLMFSHNMSSKTPLVLLHGFGGGLGLWALNFEDLSTDRPVYAFDLLGFGRSSRPRFDSDAEEVENQFVESIEEWRCALRLDKMILLGHNLGGFLAAAYSLKYPSRVSHLILVEPWGFPERPDLADQERPIPVWIRALGAALTPFNPLAGLRIAGPFGLSLVQRLRPDFKRKYSSMFEDDTVTEYIYHCNVQTPSGETAFKNMTIPYGWAKRPMLQRIGGLHPDIPVSVIFGARSCIDGNSGTSIQSLRPKSYVKTIAILGAGHYVYADQPEEFNQKVKEICHTVD
uniprot
proteins
ec_number
2.3.1.51
uniprot
proteins
function
FUNCTION: Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfer of an acyl group on a lysophosphatidic acid. Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors (By similarity). Functions in phosphatidic acid biosynthesis (By similarity). May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2 (By similarity). Involved in keratinocyte differentiation (By similarity). Regulates lipid droplet fusion (By similarity). {ECO:0000250|UniProtKB:Q8WTS1, ECO:0000250|UniProtKB:Q9DBL9}.
uniprot
proteins
mass_dalton
39104
uniprot
proteins
mutagenesis
MUTAGEN 9; /note="E->K: Colocalized to the lipid droplets with PLIN and ADPR."; /evidence="ECO:0000269|PubMed:15136565"; MUTAGEN 132; /note="Q->P: Exhibits a diffuse cytoplasmic distribution without colocalization to lipid droplets with PLIN and ADPR. Loss of binding to PLIN."; /evidence="ECO:0000269|PubMed:15136565"; MUTAGEN 262; /note="E->K: Exhibits a diffuse cytoplasmic distribution without colocalization to lipid droplets with PLIN and ADPR. Loss of binding to PLIN."; /evidence="ECO:0000269|PubMed:15136565
uniprot
proteins
protein_family
ABHD4/ABHD5 subfamily
uniprot
proteins
protein_family
Peptidase S33 family
uniprot
proteins
pubmed
15136565
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23408028
uniprot
proteins
sequence_length
351
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15136565}. Lipid droplet {ECO:0000269|PubMed:15136565}. Note=Colocalized with PLIN and ADRP on the surface of lipid droplets. The localization is dependent upon the metabolic status of the adipocytes and the activity of PKA.
uniprot
proteins