Adar
entrez
81635
canonical
uniprot
P55266
canonical
ensembl
ENSRNOG00000020744
resolver
ensp
ENSRNOP00000028181
resolver
ensp
ENSRNOP00000090863
resolver
enst
ENSRNOT00000093799
resolver
genesymbol
Adar
resolver
genesymbol_syn
Dsrad
resolver
uniprot
A0A8I6AEC1
resolver
uniprot_entry
A0A8I6AEC1_RAT
resolver
uniprot_entry
DSRAD_RAT
resolver
amino_acid_sequence
MSQGFRGPTGVFPHQTQPCLDPSYEHSKWRYLQPRGSESYLRSFQLQQIEFLKGRLPEAPLIGAQTQSLPPFLPGHWPRFPGPPAQGKQPEIWGFPRSVTLRNQGFHIGPPLPPPHSRGPPWRGAEGLCSHFQELSISQNPEQKVLNRLEELGEGKATTAYALARELRTPKKDINRILYSLERKGKLHRGVGKPPLWSLVPLSQACTQPPRAVNSDKEVPRGEPDLDSEDGDPASDLEGPSELLDMAEIKEKICDYLFNVSKSSALNLAKNIGLAKARDVNAVLIDLERQGDVYREGATPPIWYLTDKKRERLQMKRSTHSGPAATPAAVSEATQSTSFPTCHPPQSGGSSSMATSKRVENGQEPVTKYESRHEARPGPVRLRPHAYHNGPSRAGYVASENGPWATDDIPDNLNSIHTAPGEFRAIMEMPSFYSPTLPRCSPYKKLTECQLKNPVSGLLEYAQFTSQTCDFNLIEQSGPSHEPRFKFQVVINGREFPPAEAGSKKVAKQDAAVKAMAILLREAKAKDSGQPEELSNCPMEEDPEKPAESQPPSSSATSLFSGKSPVTTLLECMHKLGNSCEFRLLSKEGPAHDPKFQYCVAVGAQTFPSVSAPSKKVAKQMAAEEAMKALQEEAANSADDQSGGANTDSLDESVAPNKIRRIGELVRYLNTNPVGGLLEYARSHGFAAEFKLIDQSGPPHEPKFVYQAKVGGRWFPAVCAHSKKQGKQDAADAALRVLIGESEKAEQLGFAEVTPVTGASLRRTMLLLSRSPDAHPKTLPLTGSTFHDQIAMLSHRCFNALTNSFQPSLLGRKILAAIIMKRDPEDMGVVVSLGTGNRCVKGDSLSLKGETVNDCHAEIISRRGFIRFLYSELMKYNHHTAKNSIFELARGGEKLQIKKTVSFHLYISTAPCGDGAHFDKSCSDRAVESTESRHYPVFENPKQGKLRTKVENGEGTIPVESSDIVPTWDGIRLGERLRTMSCSDKILRWNVLGLQGALLTHFLQPVYLKSVTLGYLFSQGHLTRAICCRVTRDGNAFEDGLRYPFIVNHPKVGRVSVYDSKRQSGKTKETSVNWCLADGYDLEILDGTRGTVDGPGKELSRVSKKNIFLQFKKLCSFRARRDLLQLSYGEAKKAARDYDLAKNYFKKSLRDMGYGNWISKPQEEKNFYLCPVPND
uniprot
proteins
ec_number
3.5.4.37
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities. Exhibits low-level editing at the GRIA2 Q/R site, but edits efficiently at the R/G site and HOTSPOT1. Does not affect polyomavirus replication but provides protection against virus-induced cytopathic effects. Essential for embryonic development and cell survival and plays a critical role in the maintenance of hematopoietic stem cells (By similarity). {ECO:0000250|UniProtKB:P55265, ECO:0000250|UniProtKB:Q99MU3}.
uniprot
proteins
mass_dalton
129911
uniprot
proteins
post_translational_modification
PTM: Sumoylation reduces RNA-editing activity. {ECO:0000250|UniProtKB:P55265}.
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7862132
uniprot
proteins
sequence_length
1175
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P55265}. Nucleus {ECO:0000250|UniProtKB:P55265}. Note=Shuttles between the cytoplasm and nucleus. {ECO:0000250|UniProtKB:P55265}.
uniprot
proteins