PPP1R35
entrez
221908
canonical
uniprot
Q8TAP8
canonical
ensembl
ENSG00000160813
resolver
ensp
ENSP00000292330
resolver
ensp
ENSP00000651386
resolver
enst
ENST00000292330
resolver
genesymbol
PPP1R35
resolver
genesymbol_syn
C7orf47
resolver
hgnc
HGNC:28320
resolver
uniprot
A4D2C5
resolver
uniprot_entry
PPR35_HUMAN
resolver
uniprot_sec
A4D2C5
resolver
amino_acid_sequence
MMMGCGESELKSADGEEAAAVPGPPPEPQVPQLRAPVPEPGLDLSLSPRPDSPQPRHGSPGRRKGRAERRGAARQRRQVRFRLTPPSPVRSEPQPAVPQELEMPVLKSSLALGLELRAAAGSHFDAAKAVEEQLRKSFQIRCGLEESVSEGLNVPRSKRLFRDLVSLQVPEEQVLNAALREKLALLPPQARAPHPKEPPGPGPDMTILCDPETLFYESPHLTLDGLPPLRLQLRPRPSEDTFLMHRTLRRWEA
uniprot
proteins
function
FUNCTION: During centriole duplication, plays a role in the centriole elongation by promoting the recruitment of the microtubule-binding elongation machinery through its interaction with RTTN, leading to the centriole to centrosome conversion (PubMed:30168418, PubMed:30230954). In addition, may play a role in the primary cilia assembly (By similarity). {ECO:0000250|UniProtKB:Q9D8C8, ECO:0000269|PubMed:30168418, ECO:0000269|PubMed:30230954}.
uniprot
proteins
mass_dalton
27953
uniprot
proteins
mutagenesis
MUTAGEN 45; /note="S->A: Does not affect centrosome localization; when associated with A-47 and A-52. Does not affect interaction with RTTN; when associated with A-47 and A-52."; /evidence="ECO:0000269|PubMed:30168418"; MUTAGEN 45; /note="S->D: Does not affect centrosome localization; when associated with D-47 and D-52. Does not affect interaction with RTTN; when associated with D-47 and D-52."; /evidence="ECO:0000269|PubMed:30168418"; MUTAGEN 47; /note="S->A: Does not affect centrosome localization; when associated with A-45 and A-52. Does not affect interaction with RTTN; when associated with A-45 and A-52."; /evidence="ECO:0000269|PubMed:30168418"; MUTAGEN 47; /note="S->D: Does not affect centrosome localization; when associated with D-45 and D-52. Does not affect interaction with RTTN; when associated with D-45 and D-52."; /evidence="ECO:0000269|PubMed:30168418"; MUTAGEN 52; /note="S->A: Does not affect centrosome localization; when associated with A-45 and A-47. Does not affect interaction with RTTN; when associated with A-45 and A-47."; /evidence="ECO:0000269|PubMed:30168418"; MUTAGEN 52; /note="S->D: Does not affect centrosome localization; when associated with D-45 and D-47. Does not affect interaction with RTTN; when associated with D-45 and D-47."; /evidence="ECO:0000269|PubMed:30168418"; MUTAGEN 79; /note="V->A: Does not affect centriole localization; when associated with A-81. Does not affect interaction with RTTN; when associated with A-81."; /evidence="ECO:0000269|PubMed:30168418"; MUTAGEN 81; /note="F->A: Does not affect centriole localization; when associated with A-79. Does not affect interaction with RTTN; when associated with A-79."; /evidence="ECO:0000269|PubMed:30168418
uniprot
proteins
protein_family
PPP1R35 family
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19389623
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
30168418
uniprot
proteins
pubmed
30230954
uniprot
proteins
sequence_length
253
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:30168418}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:30168418, ECO:0000269|PubMed:30230954}. Note=Recruited to the nascent daughter centriole early in the duplication cycle and localizes to the proximal centriolar lumen just above the cartwheel (PubMed:30168418, PubMed:30230954). Co-localizes with RTTN at the centriole (PubMed:30168418). {ECO:0000269|PubMed:30168418, ECO:0000269|PubMed:30230954}.
uniprot
proteins