NFIL3
entrez
4783
canonical
uniprot
Q16649
canonical
ensembl
ENSG00000165030
resolver
ensp
ENSP00000297689
resolver
ensp
ENSP00000520782
resolver
ensp
ENSP00000546838
resolver
ensp
ENSP00000546839
resolver
ensp
ENSP00000546840
resolver
ensp
ENSP00000546841
resolver
ensp
ENSP00000546842
resolver
ensp
ENSP00000609042
resolver
ensp
ENSP00000609043
resolver
ensp
ENSP00000638931
resolver
ensp
ENSP00000638932
resolver
ensp
ENSP00000638933
resolver
ensp
ENSP00000638934
resolver
ensp
ENSP00000638935
resolver
ensp
ENSP00000761959
resolver
enst
ENST00000297689
resolver
enst
ENST00000718345
resolver
enst
ENST00000876779
resolver
enst
ENST00000876780
resolver
enst
ENST00000876781
resolver
enst
ENST00000876782
resolver
enst
ENST00000876783
resolver
enst
ENST00000938983
resolver
enst
ENST00000938984
resolver
enst
ENST00000968872
resolver
enst
ENST00000968873
resolver
enst
ENST00000968874
resolver
enst
ENST00000968875
resolver
enst
ENST00000968876
resolver
genesymbol
NFIL3
resolver
genesymbol_syn
E4BP4
resolver
genesymbol_syn
IL3BP1
resolver
hgnc
HGNC:7787
resolver
uniprot
B2R9Y8
resolver
uniprot
Q14211
resolver
uniprot
Q6FGQ8
resolver
uniprot
Q96HS0
resolver
uniprot_entry
NFIL3_HUMAN
resolver
uniprot_sec
B2R9Y8
resolver
uniprot_sec
Q14211
resolver
uniprot_sec
Q6FGQ8
resolver
uniprot_sec
Q96HS0
resolver
amino_acid_sequence
MQLRKMQTVKKEQASLDASSNVDKMMVLNSALTEVSEDSTTGEELLLSEGSVGKNKSSACRRKREFIPDEKKDAMYWEKRRKNNEAAKRSREKRRLNDLVLENKLIALGEENATLKAELLSLKLKFGLISSTAYAQEIQKLSNSTAVYFQDYQTSKSNVSSFVDEHEPSMVSSSCISVIKHSPQSSLSDVSEVSSVEHTQESSVQGSCRSPENKFQIIKQEPMELESYTREPRDDRGSYTASIYQNYMGNSFSGYSHSPPLLQVNRSSSNSPRTSETDDGVVGKSSDGEDEQQVPKGPIHSPVELKHVHATVVKVPEVNSSALPHKLRIKAKAMQIKVEAFDNEFEATQKLSSPIDMTSKRHFELEKHSAPSMVHSSLTPFSVQVTNIQDWSLKSEHWHQKELSGKTQNSFKTGVVEMKDSGYKVSDPENLYLKQGIANLSAEVVSLKRLIATQPISASDSG
uniprot
proteins
function
FUNCTION: Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B-site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity). Represses the transcription of CYP2A5 (By similarity). Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2 (By similarity). Required for the development of natural killer cell precursors (By similarity). {ECO:0000250|UniProtKB:O08750, ECO:0000269|PubMed:1620116, ECO:0000269|PubMed:7565758, ECO:0000269|PubMed:8836190}.
uniprot
proteins
mass_dalton
51472
uniprot
proteins
mutagenesis
MUTAGEN 330; /note="K->A: Interacts with DR1 and partially affects transcriptional repression; when associated with E-332."; /evidence="ECO:0000269|PubMed:8836190"; MUTAGEN 330; /note="K->E: Does not interact with DR1 and drastically affects transcriptional repression; when associated with E-332."; /evidence="ECO:0000269|PubMed:8836190"; MUTAGEN 332; /note="K->A: Interacts with DR1 and partially affects transcriptional repression; when associated with E-330."; /evidence="ECO:0000269|PubMed:8836190"; MUTAGEN 332; /note="K->E: Does not interact with DR1 and drastically affects transcriptional repression; when associated with E-330."; /evidence="ECO:0000269|PubMed:8836190
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
protein_family
NFIL3 subfamily
uniprot
proteins
pubmed
10942106
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1620116
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24062447
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
7565758
uniprot
proteins
pubmed
8836190
uniprot
proteins
sequence_length
462
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
uniprot
proteins