Numbl
entrez
292732
canonical
uniprot
A1L1I3
canonical
ensembl
ENSRNOG00000020867
resolver
ensp
ENSRNOP00000054039
resolver
genesymbol
Numbl
resolver
genesymbol_syn
Nbl
resolver
uniprot
Q3MUI2
resolver
uniprot_entry
NUMBL_RAT
resolver
uniprot_entry
Q3MUI2_RAT
resolver
amino_acid_sequence
MSRSAAASGGPRRPDQHLPPAPCGASGPPETFRTESDGAGTMNKLRQSLRRRKPAYVPEASRPHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCEDAVKKLKAMGRKSVKSVLWVSADGLRVVDDKTKDLLVDQTIEKVSFCAPDRNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCAFAACLERKQRREKECGVTAAFDASRTSFAREGSFRLSGGGRPAEREAGDKKKAEAAAAPAVAPGPAQPGHVSPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQLSLRLNELPSTLQRRTDFQVKGTVPEMEPPGTGDSDGISALCTQISSSFASAGAPVPGPPSATTGTSAWGEPSVPAATAFQPGHKRTPSEAERWLEEVSQVAKAQQQQQQQQQQQQQQQQQQQQQQQQQATSVPPMPTMAPTLQPFSTPVGPFDTAAAQVAVFLPPTHMQPPFVPAYPGLGYPPMPRVPVVGITPSQMVANAFCSAAQLQPQPATLLGKAGAFPPPTAPSAPGGQARPRPNGAPWPPEPAPAPAPELDPFEAQWAALEGKPAVEKPSNPFSGDLQKTFEIEL
uniprot
proteins
function
FUNCTION: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
65513
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18299187
uniprot
proteins
pubmed
20079715
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
614
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the CNS. {ECO:0000250}.
uniprot
proteins