PLSCR4
entrez
57088
canonical
uniprot
Q9NRQ2
canonical
ensembl
ENSG00000114698
resolver
ensp
ENSP00000347038
resolver
ensp
ENSP00000372561
resolver
ensp
ENSP00000399315
resolver
ensp
ENSP00000415605
resolver
ensp
ENSP00000419040
resolver
ensp
ENSP00000576303
resolver
ensp
ENSP00000576306
resolver
ensp
ENSP00000576307
resolver
ensp
ENSP00000621349
resolver
ensp
ENSP00000644339
resolver
ensp
ENSP00000644340
resolver
ensp
ENSP00000697517
resolver
enst
ENST00000383083
resolver
genesymbol
PLSCR4
resolver
hgnc
HGNC:16497
resolver
uniprot
A8K2E9
resolver
uniprot
E9PHR9
resolver
uniprot
Q2TTR3
resolver
uniprot
Q658L3
resolver
uniprot
Q6ZR73
resolver
uniprot
Q7Z505
resolver
uniprot_entry
E9PHR9_HUMAN
resolver
uniprot_entry
PLS4_HUMAN
resolver
uniprot_sec
A8K2E9
resolver
uniprot_sec
Q2TTR3
resolver
uniprot_sec
Q658L3
resolver
uniprot_sec
Q6ZR73
resolver
uniprot_sec
Q7Z505
resolver
amino_acid_sequence
MSGVVPTAPEQPAGEMENQTKPPDPRPDAPPEYNSHFLPGPPGTAVPPPTGYPGGLPMGYYSPQQPSTFPLYQPVGGIHPVRYQPGKYPMPNQSVPITWMPGPTPMANCPPGLEYLVQLDNIHVLQHFEPLEMMTCFETNNRYDIKNNSDQMVYIVTEDTDDFTRNAYRTLRPFVLRVTDCMGREIMTMQRPFRCTCCCFCCPSARQELEVQCPPGVTIGFVAEHWNLCRAVYSIQNEKKENVMRVRGPCSTYGCGSDSVFEVKSLDGISNIGSIIRKWNGLLSAMADADHFDIHFPLDLDVKMKAMIFGACFLIDFMYFERSPPQRSR
uniprot
proteins
function
FUNCTION: Catalyzes metal ion-induced ATP-independent rapid bidirectional and non-specific movement of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane and participates in the redistribution of phospholipids between membrane leaflets (PubMed:23089641). Metal ions bind to the calcium-binding site and induce conformation change in the protein (PubMed:23089641). Has a greater affi nity for Ca(2+) than Mg(2+) and Zn(2+) (PubMed:23089641). {ECO:0000269|PubMed:23089641}.
uniprot
proteins
mass_dalton
37005
uniprot
proteins
mutagenesis
MUTAGEN 197..204; /note="CCCFCCPS->AAAFAAPA: Affects plasma membrane localization."; /evidence="ECO:0000269|PubMed:21690087"; MUTAGEN 277..279; /note="RKW->AAA: Reduces nuclear localization."; /evidence="ECO:0000269|PubMed:21690087"; MUTAGEN 277; /note="R->A: Markedly reduces nuclear localization."; /evidence="ECO:0000269|PubMed:21690087"; MUTAGEN 290; /note="D->A: 50% decrease in scramblase activity in presence of Ca2+, and 40% decrease in scramblase activity in presence of Mg2+."; /evidence="ECO:0000269|PubMed:23089641
uniprot
proteins
protein_family
Phospholipid scramblase family
uniprot
proteins
pubmed
10930526
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18256029
uniprot
proteins
pubmed
21690087
uniprot
proteins
pubmed
23089641
uniprot
proteins
sequence_length
329
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21690087}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O15162}. Cell membrane {ECO:0000305|PubMed:21690087}; Lipid-anchor {ECO:0000305|PubMed:21690087}; Cytoplasmic side {ECO:0000250|UniProtKB:O15162}. Nucleus {ECO:0000269|PubMed:21690087}. Note=Palmitoylation regulates its localization to the cell membrane or the nucleus; trafficking to the cell membrane is dependent upon palmitoylation whereas in the absence of palmitoylation, localizes to the nucleus. {ECO:0000305|PubMed:21690087}.
uniprot
proteins
transmembrane_region
TRANSMEM 304..320; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O15162
uniprot
proteins