Ca5a
entrez
12352
canonical
uniprot
P23589
canonical
ensembl
ENSMUSG00000025317
resolver
ensp
ENSMUSP00000060457
resolver
enst
ENSMUST00000057653
resolver
genesymbol
Ca5a
resolver
genesymbol_syn
Ca5
resolver
genesymbol_syn
Car5
resolver
genesymbol_syn
Car5a
resolver
uniprot_entry
CAH5A_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by acetazolamide, ethoxzolamide and cyanate. {ECO:0000269|PubMed:7929150}.
uniprot
proteins
amino_acid_sequence
MLRRDPRKPLAILRHVGLLCATGPQRWRFQHSCAEEHSNCARHPLWTGPVSSAEGTRQSPINIQWKDSVYDPQLAPLRVSYDAASCRYLWNTGYFFQVEFDDSCEDSGISGGPLGNHYRLKQFHFHWGATDEWGSEHAVDGHTYPAELHLVHWNSTKYENYKKASVGENGLAVIGVFLKLGAHHQALQKLVDVLPEVRHKDTQVAMGPFDPSCLLPACRDYWTYPGSLTTPPLAESVTWIVQKTPVEVSPSQLSTFRTLLFSGRGEEEDVMVNNYRPLQPLRDRKLRSSFRLDRTKMRS
uniprot
proteins
ec_number
4.2.1.1
uniprot
proteins
function
FUNCTION: Mitochondrial carbonic anhydrase that catalyzes the reversible conversion of carbon dioxide to bicarbonate/HCO3 (PubMed:7937950, PubMed:7929150). Mitochondria are impermeable to HCO3, and thus this intramitochondrial carbonic anhydrase is pivotal in providing HCO3 for multiple mitochondrial enzymes that catalyze the formation of essential metabolites of intermediary metabolism in the urea and Krebs cycles (By similarity). {ECO:0000250|UniProtKB:P35218, ECO:0000269|PubMed:7929150, ECO:0000269|PubMed:7937950}.
uniprot
proteins
mass_dalton
34072
uniprot
proteins
mutagenesis
MUTAGEN 94; /note="Y->A,H: No effect on carbonate dehydratase activity."; /evidence="ECO:0000269|PubMed:7479916, ECO:0000269|PubMed:7929150, ECO:0000269|PubMed:8794740"; MUTAGEN 94; /note="Y->H: No effect on carbonate dehydratase activity. Enhanced proton transfer due to removal of the steric hindrance of F-95; when associated with A-95."; /evidence="ECO:0000269|PubMed:7479916, ECO:0000269|PubMed:8794740"; MUTAGEN 95; /note="F->A: No effect on carbonate dehydratase activity. Enhanced proton transfer; when associated with H-94 or C-161."; /evidence="ECO:0000269|PubMed:11851394, ECO:0000269|PubMed:8794740, ECO:0000269|PubMed:9882455"; MUTAGEN 121; /note="K->C: No effect on carbonate dehydratase activity."; /evidence="ECO:0000269|PubMed:9882455"; MUTAGEN 161; /note="Y->A: No effect on carbonate dehydratase activity."; /evidence="ECO:0000269|PubMed:11851394, ECO:0000269|PubMed:8794740, ECO:0000269|PubMed:9882455"; MUTAGEN 161; /note="Y->C: No effect on carbonate dehydratase activity. Enhanced proton transfer; when associated with A-95."; /evidence="ECO:0000269|PubMed:11851394, ECO:0000269|PubMed:8794740, ECO:0000269|PubMed:9882455"; MUTAGEN 161; /note="Y->H: No effect on carbonate dehydratase activity."; /evidence="ECO:0000269|PubMed:11851394, ECO:0000269|PubMed:8794740, ECO:0000269|PubMed:9882455
uniprot
proteins
protein_family
Alpha-carbonic anhydrase family
uniprot
proteins
pubmed
11851394
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2109313
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
7479916
uniprot
proteins
pubmed
7929150
uniprot
proteins
pubmed
7937950
uniprot
proteins
pubmed
8794740
uniprot
proteins
pubmed
9882455
uniprot
proteins
sequence_length
299
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:7937950}.
uniprot
proteins