Hal
entrez
15109
canonical
uniprot
P35492
canonical
ensembl
ENSMUSG00000020017
resolver
ensp
ENSMUSP00000123336
resolver
enst
ENSMUST00000129421
resolver
genesymbol
Hal
resolver
genesymbol_syn
Hsd
resolver
genesymbol_syn
Huth
resolver
uniprot
B2RXW1
resolver
uniprot
Q8CE60
resolver
uniprot_entry
B2RXW1_MOUSE
resolver
uniprot_entry
HUTH_MOUSE
resolver
uniprot_entry
Q8CE60_MOUSE
resolver
amino_acid_sequence
MPRYTVHVRGEWLAVPCQDGKLTVGWLGREAVRRYMKNKPDNGGFTSVDEVQFLVHRCKGLGLLDNEDELEVALEDNEFVEVVIEGDVMSPDFIPSQPEGVFLYSKYREPEKYIALDGDSLSTEDLVNLGKGRYKIKLTSIAEKKVQQSREVIDSIIKERTVVYGITTGFGKFARTVIPANKLQELQVNLVRSHSSGVGKPLSPERCRMLLALRINVLAKGYSGISLETLKQVIEAFNASCLSYVPEKGTVGASGDLAPLSHLALGLIGEGKMWSPKSGWADAKYVLEAHGLKPIVLKPKEGLALINGTQMITSLGCEALERASAIARQADIVAALTLEVLKGTTKAFDTDIHAVRPHRGQIEVAFRFRSLLDSDHHPSEIAESHRFCDRVQDAYTLRCCPQVHGVVNDTIAFVKDIITTELNSATDNPMVFASRGETISGGNFHGEYPAKALDYLAIGVHELAAISERRIERLCNPSLSELPAFLVAEGGLNSGFMIAHCTAAALVSESKALCHPSSVDSLSTSAATEDHVSMGGWAARKALRVVEHVEQVLAIELLAACQGIEFLRPLKTTTPLEKVYDLVRSVVRPWIKDRFMAPDIEAAHRLLLDQKVWEVAAPYIEKYRMEHIPESRPLSPTAFSLESLRKNSATIPESDDL
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Hal are the cause of histidinemia (His). {ECO:0000269|PubMed:8486363}.
uniprot
proteins
ec_number
4.3.1.3
uniprot
proteins
function
FUNCTION: Catalyzes the first reaction in histidine catabolism, the non-oxidative deamination of L-histidine to trans-urocanic. {ECO:0000269|PubMed:8486363}.
uniprot
proteins
mass_dalton
72258
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.
uniprot
proteins
post_translational_modification
PTM: Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly. {ECO:0000250}.
uniprot
proteins
protein_family
PAL/histidase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8486363
uniprot
proteins
sequence_length
657
uniprot
proteins