Dusp22
entrez
105352
canonical
uniprot
Q99N11
canonical
ensembl
ENSMUSG00000069255
resolver
ensp
ENSMUSP00000089260
resolver
ensp
ENSMUSP00000093603
resolver
genesymbol
Dusp22
resolver
uniprot
Q5SQN9
resolver
uniprot
Q5SQP0
resolver
uniprot_entry
DUS22_MOUSE
resolver
uniprot_sec
Q5SQN9
resolver
uniprot_sec
Q5SQP0
resolver
amino_acid_sequence
MGSGMSQILPGLYIGNFKDARDAEQLSRNKVTHILSVHDTARPMLEGVKYLCIPAADTPSQNLTRHFKESIKFIHECRLQGESCLVHCLAGVSRSVTLVIAYIMTVTDFGWEDALHTVRAGRSCANPNLGFQRQLQEFEKHEVHQYRQWLREEYGENPLRDAEEAKNILAAPGILKYWAFLRRL
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Dual specificity phosphatase; can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues (By similarity). Activates the JNK signaling pathway (By similarity). Inhibits T-cell receptor signaling and T-cell mediated immune responses, acting, at least in part, by inducing degradation of E3 ubiquitin ligase UBR2 (By similarity). Dephosphorylates and thereby induces 'Lys-48'-linked ubiquitination of UBR2, leading to proteasomal degradation of UBR2 (By similarity). Dephosphorylates and thereby inactivates tyrosine kinase LCK (By similarity). Inhibits UBR2-mediated 'Lys-63'-linked ubiquitination of LCK (By similarity). May play a role in B-cell receptor (BCR) signaling and B-cell function (PubMed:24714587). {ECO:0000250|UniProtKB:Q9NRW4, ECO:0000269|PubMed:24714587}.
uniprot
proteins
mass_dalton
20997
uniprot
proteins
post_translational_modification
PTM: Myristoylation regulates subcellular location, and is necessary for activation of JNK. {ECO:0000250|UniProtKB:Q9NRW4}.
uniprot
proteins
protein_family
Non-receptor class dual specificity subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
11346645
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23997090
uniprot
proteins
pubmed
24714587
uniprot
proteins
sequence_length
184
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9NRW4}.
uniprot
proteins