Prdx5
entrez
54683
canonical
uniprot
P99029
canonical
ensembl
ENSMUSG00000024953
resolver
ensp
ENSMUSP00000025904
resolver
ensp
ENSMUSP00000158249
resolver
genesymbol
Prdx5
resolver
genesymbol_syn
Prdx6
resolver
uniprot
Q9QX45
resolver
uniprot
Q9QZ75
resolver
uniprot_entry
PRDX5_MOUSE
resolver
uniprot_sec
Q9QX45
resolver
uniprot_sec
Q9QZ75
resolver
amino_acid_sequence
MLQLGLRVLGCKASSVLRASTCLAGRAGRKEAGWECGGARSFSSSAVTMAPIKVGDAIPSVEVFEGEPGKKVNLAELFKGKKGVLFGVPGAFTPGCSKTHLPGFVEQAGALKAKGAQVVACLSVNDVFVIEEWGRAHQAEGKVRLLADPTGAFGKATDLLLDDSLVSLFGNRRLKRFSMVIDNGIVKALNVEPDGTGLTCSLAPNILSQL
uniprot
proteins
ec_number
1.11.1.24
uniprot
proteins
function
FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. {ECO:0000269|PubMed:10679306}.
uniprot
proteins
mass_dalton
21897
uniprot
proteins
post_translational_modification
PTM: S-palmitoylated. Palmitoylation occurs on the active site, inhibiting its reactivity; therefore PRDX5 palmitoylation status determines its antioxidant capacity. {ECO:0000269|PubMed:31740833}.; PTM: [Isoform Mitochondrial]: S-palmitoylated. Depalmitoylated by ABHD10. {ECO:0000250|UniProtKB:P30044}.
uniprot
proteins
protein_family
Peroxiredoxin family
uniprot
proteins
protein_family
Prx5 subfamily
uniprot
proteins
pubmed
10514471
uniprot
proteins
pubmed
10521424
uniprot
proteins
pubmed
10679306
uniprot
proteins
pubmed
10753630
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
31740833
uniprot
proteins
sequence_length
210
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform Mitochondrial]: Mitochondrion {ECO:0000250|UniProtKB:P30044}.; SUBCELLULAR LOCATION: [Isoform Cytoplasmic+peroxisomal]: Cytoplasm {ECO:0000250|UniProtKB:P30044}. Peroxisome matrix {ECO:0000250|UniProtKB:P30044}.
uniprot
proteins