Foxr1
entrez
382074
canonical
uniprot
Q3UTB7
canonical
ensembl
ENSMUSG00000074397
resolver
ensp
ENSMUSP00000096436
resolver
genesymbol
Foxr1
resolver
genesymbol_syn
Foxn5
resolver
genesymbol_syn
Gm1115
resolver
uniprot_entry
FOXR1_MOUSE
resolver
amino_acid_sequence
MGNECFLTFTTTHLSEAEQKLALYRLQLVEPPKLPLEKKTNPDKDGPDIKPNLWMWVNPNMVYPPGKLEVAVKEEDQSALSAFQPALKEEEDSCSEASEVQQPLPPCRQKRKQRRSTVPLPLAPGRRAPLENPWRLPQAISPEGRLWSRPPLHYFHLIALALRNSPPCGLSVQQIYSFTREHFPFFRTAPEAWKNTVRHNLSFRDSFEKVPASRQGGASTGPRSCLWKLTEEGHRRFSKEARTLASTQLQSIQQCMSQPGVKPFLFDL
uniprot
proteins
function
FUNCTION: Transcription factor which acts as both an activator and a repressor (By similarity). Activates transcription of a number of genes including the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 which are involved in protection against oxidative stress (By similarity). Required for normal brain development (PubMed:34723967). {ECO:0000250|UniProtKB:Q6PIV2, ECO:0000269|PubMed:34723967}.
uniprot
proteins
mass_dalton
30579
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
25609838
uniprot
proteins
pubmed
34723967
uniprot
proteins
sequence_length
268
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q6PIV2}. Cytoplasm {ECO:0000269|PubMed:25609838}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:25609838}. Note=Localizes to the nucleus and cytoplasm with higher levels in the nucleus where it is expressed in a diffuse manner (PubMed:34723967). Located in the cytoplasm of spermatocytes and strongly accumulates at the perinuclear region in elongated spermatids (PubMed:25609838). {ECO:0000269|PubMed:25609838, ECO:0000269|PubMed:34723967}.
uniprot
proteins