ASCL2
entrez
430
canonical
uniprot
Q99929
canonical
ensembl
ENSG00000183734
resolver
ensp
ENSP00000332293
resolver
enst
ENST00000331289
resolver
genesymbol
ASCL2
resolver
genesymbol_syn
BHLHA45
resolver
genesymbol_syn
HASH2
resolver
hgnc
HGNC:739
resolver
uniprot
Q6PEY9
resolver
uniprot
Q9UM68
resolver
uniprot_entry
ASCL2_HUMAN
resolver
uniprot_sec
Q6PEY9
resolver
uniprot_sec
Q9UM68
resolver
amino_acid_sequence
MDGGTLPRSAPPAPPVPVGCAARRRPASPELLRCSRRRRPATAETGGGAAAVARRNERERNRVKLVNLGFQALRQHVPHGGASKKLSKVETLRSAVEYIRALQRLLAEHDAVRNALAGGLRPQAVRPSAPRGPPGTTPVAASPSRASSSPGRGGSSEPGSPRSAYSSDDSGCEGALSPAERELLDFSSWLGGY
uniprot
proteins
function
FUNCTION: Transcription factor. Binds to E-box motifs 5'-CANNTG-3' in the regulatory elements of target genes, probably as a heterodimer with another basic helix-loop-helix (bHLH) protein such as the transcription factor TCF3. May bind both open and closed chromatin, acting as a pioneer transcription factor to allow other factors to bind and activate lineage-specific genes. Required during post-implantation development for the generation of some differentiated trophoblast cell types. Transcriptional activity of ASCL2 may be antagonised in a subset of trophoblast cells by bHLH transcription factor HAND1, perhaps by competing for dimerization with other bHLH proteins. Involved in differentiation and function of follicular T-helper (Tfh) cells, thereby playing a role in germinal center responses; probably modulates expression of genes involved in Tfh cell function, such as BCL6. May also act as a suppressor of Th1-, Th2- and Th17-cell differentiation. Induces the formation of stem cells in intestinal crypts in vitro, synergistically activating transcription of target genes, such as SOX9, together with TCF4/beta-catenin. May form a bistable transcriptional switch, controlling expression of its own gene together with Wnt/R-spondin signaling, and thereby maintaining stem cell characteristics (By similarity). Modulates expression of target genes, including perhaps down-regulating EGR1/Krox24 and chemokine CXCL10/Mob-1 and up-regulating CXCR4 and CDKN1C/p57kip2, in Schwann cells. May play a role in reducing proliferation of Schwann cells, perhaps acting via modulation of expression of CDKN1C (By similarity). May be dispensable for blastocyst formation and later embryonic function (By similarity). May be involved in the determination of neuronal precursors (By similarity). {ECO:0000250|UniProtKB:O35885, ECO:0000250|UniProtKB:P19360}.
uniprot
proteins
mass_dalton
20185
uniprot
proteins
pubmed
11440538
uniprot
proteins
pubmed
12099555
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24463518
uniprot
proteins
pubmed
8751384
uniprot
proteins
pubmed
9175731
uniprot
proteins
sequence_length
193
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:11440538}.
uniprot
proteins