KLK4
entrez
9622
canonical
uniprot
Q9Y5K2
canonical
ensembl
ENSG00000167749
resolver
ensp
ENSP00000326159
resolver
ensp
ENSP00000472091
resolver
enst
ENST00000324041
resolver
enst
ENST00000602148
resolver
genesymbol
KLK4
resolver
genesymbol_syn
EMSP1
resolver
genesymbol_syn
PRSS17
resolver
genesymbol_syn
PSTS
resolver
hgnc
HGNC:6365
resolver
uniprot
A0A0C4DFQ5
resolver
uniprot
M0R1S9
resolver
uniprot
Q4VB16
resolver
uniprot
Q5BQA0
resolver
uniprot
Q96RU5
resolver
uniprot
Q9GZL6
resolver
uniprot
Q9UBJ6
resolver
uniprot_entry
A0A0C4DFQ5_HUMAN
resolver
uniprot_entry
KLK4_HUMAN
resolver
uniprot_entry
M0R1S9_HUMAN
resolver
uniprot_entry
Q5BQA0_HUMAN
resolver
uniprot_sec
Q4VB16
resolver
uniprot_sec
Q96RU5
resolver
uniprot_sec
Q9GZL6
resolver
uniprot_sec
Q9UBJ6
resolver
amino_acid_sequence
MATAGNPWGWFLGYLILGVAGSLVSGSCSQIINGEDCSPHSQPWQAALVMENELFCSGVLVHPQWVLSAAHCFQNSYTIGLGLHSLEADQEPGSQMVEASLSVRHPEYNRPLLANDLMLIKLDESVSESDTIRSISIASQCPTAGNSCLVSGWGLLANGRMPTVLQCVNVSVVSEEVCSKLYDPLYHPSMFCAGGGHDQKDSCNGDSGGPLICNGYLQGLVSFGKAPCGQVGVPGVYTNLCKFTEWIEKTVQAS
uniprot
proteins
disease_involvement
DISEASE: Amelogenesis imperfecta, hypomaturation type, 2A1 (AI2A1) [MIM:204700]: A defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel. {ECO:0000269|PubMed:15235027}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Has a major role in enamel formation (PubMed:15235027). Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity). {ECO:0000250|UniProtKB:Q9Z0M1, ECO:0000269|PubMed:15235027}.
uniprot
proteins
mass_dalton
27032
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. The N-glycan structures are of complex diantennary or triantennary type, which may be further modified with up to 2 sialic acid residues. {ECO:0000250|UniProtKB:Q9Z0M1}.
uniprot
proteins
protein_family
Kallikrein subfamily
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
10077646
uniprot
proteins
pubmed
10438493
uniprot
proteins
pubmed
10485467
uniprot
proteins
pubmed
10863090
uniprot
proteins
pubmed
11054574
uniprot
proteins
pubmed
11506707
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15235027
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16950394
uniprot
proteins
sequence_length
254
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins