PRMT3
entrez
10196
canonical
uniprot
O60678
canonical
ensembl
ENSG00000185238
resolver
ensp
ENSP00000331879
resolver
ensp
ENSP00000397766
resolver
ensp
ENSP00000726526
resolver
genesymbol
PRMT3
resolver
genesymbol_syn
HRMT1L3
resolver
hgnc
HGNC:30163
resolver
uniprot
A0A0A0MSN7
resolver
uniprot
B4DUC7
resolver
uniprot
Q8WUV3
resolver
uniprot_entry
ANM3_HUMAN
resolver
uniprot_entry
Q8WUV3_HUMAN
resolver
uniprot_sec
A0A0A0MSN7
resolver
uniprot_sec
B4DUC7
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by N-ethylmaleimide and high concentrations of zinc chloride (By similarity). Allosterically inhibited by SGC707 (PubMed:25728001). Allosterically inhibited by (1-(benzo[d][1,2,3]thiadiazol- 6-yl)-3-(2-cyclohexenylethyl)urea) and derivatives thereof (PubMed:22795084, PubMed:23445220). {ECO:0000250|UniProtKB:O70467, ECO:0000269|PubMed:22795084, ECO:0000269|PubMed:23445220, ECO:0000269|PubMed:25728001}.
uniprot
proteins
amino_acid_sequence
MCSLASGATGGRGAVENEEDLPELSDSGDEAAWEDEDDADLPHGKQQTPCLFCNRLFTSAEETFSHCKSEHQFNIDSMVHKHGLEFYGYIKLINFIRLKNPTVEYMNSIYNPVPWEKEEYLKPVLEDDLLLQFDVEDLYEPVSVPFSYPNGLSENTSVVEKLKHMEARALSAEAALARAREDLQKMKQFAQDFVMHTDVRTCSSSTSVIADLQEDEDGVYFSSYGHYGIHEEMLKDKIRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEEVHLPVEKVDVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYPDICTISLVAVSDVNKHADRIAFWDDVYGFKMSCMKKAVIPEAVVEVLDPKTLISEPCGIKHIDCHTTSISDLEFSSDFTLKITRTSMCTAIAGYFDIYFEKNCHNRVVFSTGPQSTKTHWKQTVFLLEKPFSVKAGEALKGKVTVHKNKKDPRSLTVTLTLNNSTQTYGLQ
uniprot
proteins
ec_number
2.1.1.319
uniprot
proteins
function
FUNCTION: Protein-arginine N-methyltransferase that catalyzes both the monomethylation and asymmetric dimethylation of the guanidino nitrogens of arginine residues in target proteins, and therefore falls into the group of type I methyltransferases (PubMed:22795084, PubMed:23445220, PubMed:25728001, PubMed:31378783, PubMed:33495566, PubMed:39513743). Catalyzes the asymmetric arginine dimethylation at multiple sites in the Arg/Gly-rich region of small ribosomal subunit protein uS5/RPS2 (PubMed:22795084). Also appears to methylate other ribosomal proteins (By similarity). May regulate retinoic acid synthesis and signaling by inhibiting ALDH1A1 retinal dehydrogenase activity (PubMed:33495566). Contributes to methylation of histone H4 'Arg-3', a specific tag for epigenetic transcriptional activation (PubMed:25728001, PubMed:31378783, PubMed:39513743). Mediates asymmetric arginine dimethylation of histone H4 'Arg-3' (H4R3me2a) in the promoter region of miRNA miR-3648, to promote its transcription and osteogenesis (PubMed:31378783). {ECO:0000250|UniProtKB:Q922H1, ECO:0000269|PubMed:22795084, ECO:0000269|PubMed:23445220, ECO:0000269|PubMed:25728001, ECO:0000269|PubMed:31378783, ECO:0000269|PubMed:33495566, ECO:0000269|PubMed:39513743}.
uniprot
proteins
mass_dalton
59903
uniprot
proteins
mutagenesis
MUTAGEN 87; /note="Y->C: Markedly reduced affinity for RPS2."; /evidence="ECO:0000269|PubMed:21059412"; MUTAGEN 87; /note="Y->E: Markedly reduced affinity for RPS2."; /evidence="ECO:0000269|PubMed:21059412"; MUTAGEN 87; /note="Y->F: No effect on interaction with RPS2."; /evidence="ECO:0000269|PubMed:21059412"; MUTAGEN 338; /note="E->Q: Loss of catalytic activity. No effect on ALDH1A1 activity regulation."; /evidence="ECO:0000269|PubMed:25728001, ECO:0000269|PubMed:33495566"; MUTAGEN 403; /note="V->W: Reduces catalytic activity."; /evidence="ECO:0000269|PubMed:22795084"; MUTAGEN 464; /note="H->A: Loss of interaction with ALDH1A1."; /evidence="ECO:0000269|PubMed:33495566"; MUTAGEN 465; /note="N->A: Loss of interaction with ALDH1A1."; /evidence="ECO:0000269|PubMed:33495566"; MUTAGEN 466; /note="R->A: Loss of interaction with ALDH1A1."; /evidence="ECO:0000269|PubMed:33495566"; MUTAGEN 468; /note="V->A: Loss of interaction with ALDH1A1."; /evidence="ECO:0000269|PubMed:33495566
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
Protein arginine N-methyltransferase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15334060
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21059412
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22795084
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23445220
uniprot
proteins
pubmed
25728001
uniprot
proteins
pubmed
27697862
uniprot
proteins
pubmed
30530495
uniprot
proteins
pubmed
31378783
uniprot
proteins
pubmed
33495566
uniprot
proteins
pubmed
39513743
uniprot
proteins
pubmed
9642256
uniprot
proteins
sequence_length
531
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:39513743, ECO:0000269|PubMed:9642256}. Nucleus {ECO:0000269|PubMed:39513743}. Note=Localized to the nucleus by ZNF200. {ECO:0000269|PubMed:39513743}.
uniprot
proteins