Kcnab1
entrez
29737
canonical
uniprot
P63144
canonical
ensembl
ENSRNOG00000056697
resolver
ensembl
ENSRNOG00055004540
resolver
ensembl
ENSRNOG00060001239
resolver
ensembl
ENSRNOG00065027103
resolver
ensp
ENSRNOP00000072289
resolver
ensp
ENSRNOP00000078062
resolver
ensp
ENSRNOP00000095564
resolver
ensp
ENSRNOP00055005354
resolver
ensp
ENSRNOP00060000984
resolver
ensp
ENSRNOP00065038376
resolver
enst
ENSRNOT00000077973
resolver
enst
ENSRNOT00000097545
resolver
enst
ENSRNOT00000120207
resolver
enst
ENSRNOT00055007187
resolver
enst
ENSRNOT00060001769
resolver
enst
ENSRNOT00065046799
resolver
genesymbol
Kcnab1
resolver
genesymbol_syn
Kvb1
resolver
uniprot
A0A8I5Y1W3
resolver
uniprot
A0A8I6AJY2
resolver
uniprot
P97380
resolver
uniprot
Q5FWS9
resolver
uniprot
Q61763
resolver
uniprot
Q63277
resolver
uniprot_entry
A0A8I5Y1W3_RAT
resolver
uniprot_entry
A0A8I6AJY2_RAT
resolver
uniprot_entry
KCAB1_RAT
resolver
uniprot_sec
P97380
resolver
uniprot_sec
Q5FWS9
resolver
uniprot_sec
Q61763
resolver
uniprot_sec
Q63277
resolver
amino_acid_sequence
MQVSIACTEHNLKSRNGEDRLLSKQSSTAPNVVNAARAKFRTVAIIARSLGTFTPQHHISLKESTAKQTGMKYRNLGKSGLRVSCLGLGTWVTFGGQISDEVAERLMTIAYESGVNLFDTAEVYAAGKAEVILGSIIKKKGWRRSSLVITTKLYWGGKAETERGLSRKHIIEGLKGSLQRLQLEYVDVVFANRPDSNTPMEEIVRAMTHVINQGMAMYWGTSRWSAMEIMEAYSVARQFNMIPPVCEQAEYHLFQREKVEVQLPELYHKIGVGAMTWSPLACGIISGKYGNGVPESSRASLKCYQWLKERIVSEEGRKQQNKLKDLSPIAERLGCTLPQLAVAWCLRNEGVSSVLLGSSTPEQLIENLGAIQVLPKMTSHVVNEIDNILRNKPYSKKDYRS
uniprot
proteins
ec_number
1.1.1.-
uniprot
proteins
function
FUNCTION: Regulatory subunit of the voltage-gated potassium (Kv) channels composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits (By similarity). The beta-1/KCNAB1 cytoplasmic subunit mediates closure of delayed rectifier potassium channels by physically obstructing the pore via its N-terminal domain and increases the speed of channel closure for other family members (PubMed:10650996, PubMed:15618540, PubMed:16504945, PubMed:18222921, PubMed:8183366). Promotes the inactivation of KCNA1, KCNA2, KCNA4, KCNA5 and KCNA6 alpha subunit-containing channels (PubMed:10064591, PubMed:10650996, PubMed:15618540, PubMed:16504945, PubMed:8183366). Displays nicotinamide adenine dinucleotide phosphate (NADPH)-dependent aldoketoreductase activity by catalyzing the NADPH-dependent reduction of a variety of endogenous aldehydes and ketones (PubMed:18222921). The binding of NADPH is required for efficient down-regulation of potassium channel activity (PubMed:18222921). Oxidation of the bound NADPH restrains N-terminal domain from blocking the channel, thereby decreasing N-type inactivation of potassium channel activity (PubMed:18222921, PubMed:21436029). {ECO:0000250|UniProtKB:Q14722, ECO:0000269|PubMed:10064591, ECO:0000269|PubMed:10650996, ECO:0000269|PubMed:15618540, ECO:0000269|PubMed:16504945, ECO:0000269|PubMed:18222921, ECO:0000269|PubMed:21436029, ECO:0000269|PubMed:8183366}.
uniprot
proteins
mass_dalton
44710
uniprot
proteins
mutagenesis
MUTAGEN 152; /note="K->M: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:18222921
uniprot
proteins
protein_family
Shaker potassium channel beta subunit family
uniprot
proteins
pubmed
10064591
uniprot
proteins
pubmed
10477520
uniprot
proteins
pubmed
10650996
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15618540
uniprot
proteins
pubmed
16504945
uniprot
proteins
pubmed
18222921
uniprot
proteins
pubmed
19713757
uniprot
proteins
pubmed
21436029
uniprot
proteins
pubmed
8183366
uniprot
proteins
pubmed
9334400
uniprot
proteins
sequence_length
401
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q14722}. Membrane {ECO:0000269|PubMed:15618540}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell membrane {ECO:0000269|PubMed:16504945}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Recruited to the cytoplasmic side of the cell membrane via its interaction with pore-forming potassium channel alpha subunits. {ECO:0000250|UniProtKB:Q14722}.
uniprot
proteins