Ddx18
entrez
66942
canonical
uniprot
Q8K363
canonical
ensembl
ENSMUSG00000001674
resolver
ensp
ENSMUSP00000001724
resolver
enst
ENSMUST00000001724
resolver
genesymbol
Ddx18
resolver
uniprot
B2RUM8
resolver
uniprot
Q3MIB0
resolver
uniprot
Q8BVZ2
resolver
uniprot
Q9D2E0
resolver
uniprot_entry
B2RUM8_MOUSE
resolver
uniprot_entry
DDX18_MOUSE
resolver
uniprot_sec
Q3MIB0
resolver
uniprot_sec
Q8BVZ2
resolver
uniprot_sec
Q9D2E0
resolver
amino_acid_sequence
MSQLQMKLLRRKIEKRNAKLRQRNLKLQETSDTSLSQPQNGDVPKETGKGGKVKKALKRSVPVDSAEAQSGGMPEETLENGKVKKSPQKLTTLANGEAAPTPPPDSEVKKKKKKKRKMANDAGPDTKKAKTEESAEACEEPEDDVKKADDSEVPSLPLGLTGAFEDTSFASLSNLVNENTLKAIEEMGFKRMTEIQHKSIRPLLEGRDLLAAAKTGSGKTLAFLIPVIELIVKLKFMPRNGTGVLILSPTRELAMQTFGVLKELMTHHVHTYGLIMGGSNRSAEVQKLLNGINIIVATPGRLLDHMQNTPGFMYKNLQCLVIDEADRILDVGFEEELKQIIKLLPARRQTMLFSATQTRKVEDLARISLKKEPLYVGVDDDKEVATVDGLEQGYVVCPSEKRFLLLFTFLKKNRKKKVMVFFSSCMSVKYHYELLNYIDLPVLAIHGKQKQNKRTTTFFQFCNADSGILLCTDVAARGLDIPEVDWIVQYDPPDDPKEYIHRVGRTARGLNGRGHALLILRPEELGFLRYLKQSKVPLNQFDFSWSKVSDIQSQLEKLIEKNYFLHKSAQEAYKSYIRAYDSHSLKQIFNVNNLNLPQVALSFGFKVPPFVDLNVSSHDGKLKKRGGGGGFGYQKTKKVEKSKIFKHISKKPADRRQFSH
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: ATP-dependent RNA helicase that plays a role in the regulation of R-loop homeostasis in both endogenous R-loop-prone regions and at sites of DNA damage. At endogenous loci such as actively transcribed genes, may act as a helicase to resolve the formation of R-loop during transcription and prevent the interference of R-loop with DNA-replication machinery. Also participates in the removal of DNA-lesion-associated R-loop (By similarity). Plays an essential role for establishing pluripotency during embryogenesis and for pluripotency maintenance in embryonic stem cells (PubMed:31914400). Mechanistically, prevents the polycomb repressive complex 2 (PRC2) from accessing rDNA loci and protects the active chromatin status in nucleolus (PubMed:31914400). {ECO:0000250|UniProtKB:Q9NVP1, ECO:0000269|PubMed:31914400}.
uniprot
proteins
mass_dalton
74181
uniprot
proteins
protein_family
DDX18/HAS1 subfamily
uniprot
proteins
protein_family
DEAD box helicase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31914400
uniprot
proteins
sequence_length
660
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:31914400}. Chromosome {ECO:0000250|UniProtKB:Q9NVP1}.
uniprot
proteins