RASGRP4
entrez
115727
canonical
uniprot
Q8TDF6
canonical
ensembl
ENSG00000171777
resolver
ensp
ENSP00000416463
resolver
ensp
ENSP00000467604
resolver
ensp
ENSP00000468483
resolver
ensp
ENSP00000479078
resolver
ensp
ENSP00000479844
resolver
ensp
ENSP00000479888
resolver
ensp
ENSP00000484345
resolver
genesymbol
RASGRP4
resolver
hgnc
HGNC:18958
resolver
uniprot
A6H8M4
resolver
uniprot
C0LTP2
resolver
uniprot
C0LTP3
resolver
uniprot
C0LTP4
resolver
uniprot
C0LTP5
resolver
uniprot
C0LTP7
resolver
uniprot
C9J416
resolver
uniprot
C9JHZ1
resolver
uniprot
Q8N858
resolver
uniprot
Q96QN5
resolver
uniprot
Q96QN6
resolver
uniprot
Q96QN7
resolver
uniprot_entry
GRP4_HUMAN
resolver
uniprot_sec
A6H8M4
resolver
uniprot_sec
C0LTP2
resolver
uniprot_sec
C0LTP3
resolver
uniprot_sec
C0LTP4
resolver
uniprot_sec
C0LTP5
resolver
uniprot_sec
C0LTP7
resolver
uniprot_sec
C9J416
resolver
uniprot_sec
C9JHZ1
resolver
uniprot_sec
Q8N858
resolver
uniprot_sec
Q96QN5
resolver
uniprot_sec
Q96QN6
resolver
uniprot_sec
Q96QN7
resolver
amino_acid_sequence
MNRKDSKRKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDELLEKCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPLPMSSPGLGKKRKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEWAPGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFACHGLHPPPRQGRGSFSREELTGYLLRASAICSKLGLAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLCCHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASCGSEENHSYTLSLEPETGCQLRHAWTQTESPHPSWETDTVPCPVMDPPSTASSKLDS
uniprot
proteins
function
FUNCTION: Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP (PubMed:11880369, PubMed:11956218, PubMed:12493770, PubMed:18024961). In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting Ras-mediated activation of PIK3CG/PI3Kgamma to promote neutrophil functional responses (By similarity). In CD117(+) dendritic cells and mast cells, participates in an lipopolysaccharide (LPS)-activated signaling pathway that stimulates the production of interferon-gamma and other pro-inflammatory cytokines by natural killer (NK) cells (By similarity). May function in mast cell differentiation (PubMed:11880369, PubMed:11956218, PubMed:12493770, PubMed:18024961). Does not appear to be required for the development of B-cells, DC-cells, T-cells, or NK-cells (By similarity). {ECO:0000250|UniProtKB:Q8BTM9, ECO:0000269|PubMed:11880369, ECO:0000269|PubMed:11956218, ECO:0000269|PubMed:12493770, ECO:0000269|PubMed:18024961}.
uniprot
proteins
mass_dalton
74882
uniprot
proteins
mutagenesis
MUTAGEN 548; /note="F->S: Loss of cell membrane targeting."; /evidence="ECO:0000269|PubMed:18024961
uniprot
proteins
protein_family
RASGRP family
uniprot
proteins
pubmed
11880369
uniprot
proteins
pubmed
11956218
uniprot
proteins
pubmed
12493770
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18024961
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21933395
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
673
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11956218}. Cell membrane {ECO:0000269|PubMed:11956218, ECO:0000305|PubMed:11880369}. Note=Recruited to membranes upon activation by DAG. {ECO:0000250|UniProtKB:Q8BTM9}.
uniprot
proteins