CD63
entrez
967
canonical
uniprot
P08962
canonical
ensembl
ENSG00000135404
resolver
ensp
ENSP00000257857
resolver
ensp
ENSP00000393502
resolver
ensp
ENSP00000446807
resolver
ensp
ENSP00000447356
resolver
ensp
ENSP00000447730
resolver
ensp
ENSP00000448091
resolver
ensp
ENSP00000449337
resolver
ensp
ENSP00000536718
resolver
ensp
ENSP00000536719
resolver
ensp
ENSP00000536720
resolver
ensp
ENSP00000536724
resolver
ensp
ENSP00000536725
resolver
ensp
ENSP00000536728
resolver
genesymbol
CD63
resolver
genesymbol_syn
MLA1
resolver
genesymbol_syn
TSPAN30
resolver
hgnc
HGNC:1692
resolver
uniprot
F8VZE2
resolver
uniprot
Q5TZP3
resolver
uniprot
Q8N6Z9
resolver
uniprot
Q9UCG6
resolver
uniprot_entry
CD63_HUMAN
resolver
uniprot_sec
F8VZE2
resolver
uniprot_sec
Q5TZP3
resolver
uniprot_sec
Q8N6Z9
resolver
uniprot_sec
Q9UCG6
resolver
amino_acid_sequence
MAVEGGMKCVKFLLYVLLLAFCACAVGLIAVGVGAQLVLSQTIIQGATPGSLLPVVIIAVGVFLFLVAFVGCCGACKENYCLMITFAIFLSLIMLVEVAAAIAGYVFRDKVMSEFNNNFRQQMENYPKNNHTASILDRMQADFKCCGAANYTDWEKIPSMSKNRVPDSCCINVTVGCGINFNEKAIHKEGCVEKIGGWLRKNVLVVAAAALGIAFVEVLGIVFACCLVKSIRSGYEVM
uniprot
proteins
function
FUNCTION: Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. {ECO:0000269|PubMed:16917503, ECO:0000269|PubMed:21803846, ECO:0000269|PubMed:21962903, ECO:0000269|PubMed:23632027, ECO:0000269|PubMed:24635319}.
uniprot
proteins
mass_dalton
25637
uniprot
proteins
post_translational_modification
PTM: Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro). {ECO:0000269|PubMed:19640571}.
uniprot
proteins
protein_family
Tetraspanin (TM4SF) family
uniprot
proteins
pubmed
10793155
uniprot
proteins
pubmed
12754519
uniprot
proteins
pubmed
1339263
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15351990
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1599482
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
16917503
uniprot
proteins
pubmed
17897319
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
1939168
uniprot
proteins
pubmed
19640571
uniprot
proteins
pubmed
1993697
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2171551
uniprot
proteins
pubmed
21803846
uniprot
proteins
pubmed
21962903
uniprot
proteins
pubmed
22431521
uniprot
proteins
pubmed
22660413
uniprot
proteins
pubmed
23632027
uniprot
proteins
pubmed
24635319
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
3365686
uniprot
proteins
pubmed
38682696
uniprot
proteins
pubmed
4062294
uniprot
proteins
pubmed
7682577
uniprot
proteins
sequence_length
238
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15351990, ECO:0000269|PubMed:19640571, ECO:0000269|PubMed:23632027}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:19640571, ECO:0000269|PubMed:1993697, ECO:0000269|PubMed:22431521, ECO:0000269|PubMed:23632027}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000269|PubMed:10793155, ECO:0000269|PubMed:23632027}; Multi-pass membrane protein {ECO:0000255}. Endosome, multivesicular body {ECO:0000269|PubMed:21962903, ECO:0000269|PubMed:38682696}. Melanosome {ECO:0000269|PubMed:21962903}. Secreted, extracellular exosome {ECO:0000269|PubMed:22660413}. Cell surface {ECO:0000269|PubMed:16917503, ECO:0000269|PubMed:23632027, ECO:0000269|PubMed:24635319}. Note=Also found in Weibel-Palade bodies of endothelial cells (PubMed:10793155). Located in platelet dense granules (PubMed:7682577). Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies (PubMed:21962903). {ECO:0000269|PubMed:10793155, ECO:0000269|PubMed:21962903, ECO:0000269|PubMed:7682577}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 52..72; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 82..102; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 204..224; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins