SLC2A8
entrez
29988
canonical
uniprot
Q9NY64
canonical
ensembl
ENSG00000136856
resolver
ensp
ENSP00000362458
resolver
ensp
ENSP00000362469
resolver
ensp
ENSP00000391213
resolver
ensp
ENSP00000477568
resolver
ensp
ENSP00000624596
resolver
ensp
ENSP00000788461
resolver
enst
ENST00000373360
resolver
enst
ENST00000373371
resolver
enst
ENST00000610552
resolver
genesymbol
SLC2A8
resolver
genesymbol_syn
GLUT8
resolver
genesymbol_syn
GLUTX1
resolver
hgnc
HGNC:13812
resolver
uniprot
A0A087WT42
resolver
uniprot
Q5VVV9
resolver
uniprot
Q8WUZ9
resolver
uniprot
Q8WZ05
resolver
uniprot
Q9NSC4
resolver
uniprot_entry
A0A087WT42_HUMAN
resolver
uniprot_entry
Q5VVV9_HUMAN
resolver
uniprot_entry
Q8WZ05_HUMAN
resolver
uniprot_entry
SL2A8_HUMAN
resolver
uniprot_sec
Q8WUZ9
resolver
uniprot_sec
Q9NSC4
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by cytochalasin B. {ECO:0000250|UniProtKB:Q9JIF3}.
uniprot
proteins
amino_acid_sequence
MTPEDPEETQPLLGPPGGSAPRGRRVFLAAFAAALGPLSFGFALGYSSPAIPSLQRAAPPAPRLDDAAASWFGAVVTLGAAAGGVLGGWLVDRAGRKLSLLLCSVPFVAGFAVITAAQDVWMLLGGRLLTGLACGVASLVAPVYISEIAYPAVRGLLGSCVQLMVVVGILLAYLAGWVLEWRWLAVLGCVPPSLMLLLMCFMPETPRFLLTQHRRQEAMAALRFLWGSEQGWEDPPIGAEQSFHLALLRQPGIYKPFIIGVSLMAFQQLSGVNAVMFYAETIFEEAKFKDSSLASVVVGVIQVLFTAVAALIMDRAGRRLLLVLSGVVMVFSTSAFGAYFKLTQGGPGNSSHVAISAPVSAQPVDASVGLAWLAVGSMCLFIAGFAVGWGPIPWLLMSEIFPLHVKGVATGICVLTNWLMAFLVTKEFSSLMEVLRPYGAFWLASAFCIFSVLFTLFCVPETKGKTLEQITAHFEGR
uniprot
proteins
function
FUNCTION: Insulin-regulated facilitative hexose transporter that mediates the transport of glucose and fructose (By similarity). Facilitates hepatic influx of dietary trehalose, which in turn inhibits glucose and fructose influx triggering a starvation signal and hepatic autophagy through activation of AMPK and ULK1 (PubMed:27922102). Also able to mediate the transport of dehydroascorbate. {ECO:0000250|UniProtKB:Q9JIF3, ECO:0000269|PubMed:27922102}.
uniprot
proteins
mass_dalton
50819
uniprot
proteins
protein_family
Glucose transporter subfamily
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Sugar transporter (TC 2.A.1.1) family
uniprot
proteins
pubmed
10671487
uniprot
proteins
pubmed
10821868
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
27922102
uniprot
proteins
sequence_length
477
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9JJZ1}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9JJZ1}; Multi-pass membrane protein {ECO:0000255}. Note=Principally intracellular. May move between intracellular vesicles and the plasma membrane. The dileucine internalization motif is critical for intracellular sequestration. {ECO:0000250|UniProtKB:Q9JJZ1}.
uniprot
proteins
transmembrane_region
TRANSMEM 26..46; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 71..91; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 97..117; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 128..148; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 157..177; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 183..203; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 257..277; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 293..313; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 320..340; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 368..388; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 405..425; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 439..459; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins