Ca4
entrez
29242
canonical
uniprot
P48284
canonical
ensembl
ENSRNOG00000002916
resolver
ensembl
ENSRNOG00065001634
resolver
ensp
ENSRNOP00000003908
resolver
ensp
ENSRNOP00065001545
resolver
enst
ENSRNOT00065002202
resolver
genesymbol
Ca4
resolver
uniprot
Q4QR97
resolver
uniprot_entry
CAH4_RAT
resolver
uniprot_sec
Q4QR97
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by acetazolamide. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MQLLLALLALAYVAPSTEDSHWCYEIQAKEPNSHCSGPEQWTGDCKKNQQSPINIVTSKTKLNPSLTPFTFVGYDQKKKWEVKNNQHSVEMSLGEDIYIFGGDLPTQYKAIQLHLHWSEESNKGSEHSIDGKHFAMEMHVVHKKMTTGDKVQDSDSKDKIAVLAFMVEVGNEVNEGFQPLVEALSRLSKPFTNSTVSESCLQDMLPEKKKLSAYFRYQGSLTTPGCDETVIWTVFEEPIKIHKDQFLEFSKKLYYDQEQKLNMKDNVRPLQPLGNRQVFRSHASGRLLSLPLPTLLVPTLTCLVASFLH
uniprot
proteins
ec_number
4.2.1.1
uniprot
proteins
function
FUNCTION: Catalyzes the reversible hydration of carbon dioxide into bicarbonate and protons and thus is essential to maintaining intracellular and extracellular pH. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid. {ECO:0000250|UniProtKB:P22748}.
uniprot
proteins
mass_dalton
35076
uniprot
proteins
post_translational_modification
PTM: The N-terminus is blocked.; PTM: Glycosylated. {ECO:0000269|PubMed:1737787}.
uniprot
proteins
protein_family
Alpha-carbonic anhydrase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1737787
uniprot
proteins
pubmed
24090084
uniprot
proteins
pubmed
8279579
uniprot
proteins
sequence_length
309
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1737787}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:1737787}.
uniprot
proteins