Or1a1b
entrez
258706
canonical
uniprot
Q7TRX1
canonical
ensembl
ENSMUSG00000070377
resolver
ensp
ENSMUSP00000077966
resolver
ensp
ENSMUSP00000145822
resolver
ensp
ENSMUSP00000150560
resolver
enst
ENSMUST00000078936
resolver
enst
ENSMUST00000205664
resolver
enst
ENSMUST00000215550
resolver
genesymbol
Or1a1b
resolver
genesymbol_syn
Olfr43
resolver
uniprot
A0A0U1RP44
resolver
uniprot
Q05A03
resolver
uniprot_entry
Q05A03_MOUSE
resolver
uniprot_entry
Q7TRX1_MOUSE
resolver
uniprot_sec
A0A0U1RP44
resolver
amino_acid_sequence
MREENESSTTDFTLLGVTRQREQEYFFFILFLFIYPITVFGNMLIILAIHSDTRLHNPMYFFLANLSLVDIFFSSVTIPKMLANHLLGSKAISFGGCMAQMYFMIGLANTDSYILAAMAYDRAVAISRPLHYATIMSPQLCVLLVAGSWVIANANALPHTLLTARLSFCGNKDVANFYCDITPLLQLSCSDIRFNVKMMYLGVGVFSVPLLCIIISYVRVFSTVLRVPSTKGFLKALSTCGSHLTVVSLYYGTVMGMYFRPLTSYSLKHALITVMYTAVTPMLNPFIYSLRNRDMKAALKKLFHCPSSSSSLM
uniprot
proteins
function
FUNCTION: Olfactory receptor activated by various compounds, such as 3-methyl-2,4-nonanedione, citronellol and (-)-carvone (PubMed:15598656, PubMed:30639733). Ligand-binding causes a conformation change that triggers signaling via G(s)-class of G alpha protein GNAL/G(olf), mediating activation of adenylate cyclase activity and increased production of cAMP, initiating a neuronal response that triggers the perception of a smell (PubMed:15598656). In contrast to OR1A1 human ortholog, not activated by S-(+)-carvone (PubMed:28656349). Beyond its role in olfaction, may also act as a regulator of hepatic lipid accumulation (PubMed:30639733). {ECO:0000269|PubMed:15598656, ECO:0000269|PubMed:28656349, ECO:0000269|PubMed:30639733}.
uniprot
proteins
mass_dalton
35065
uniprot
proteins
mutagenesis
MUTAGEN 108; /note="A->G: Promotes activation by S-(+)-carvone; when associated with G-152."; /evidence="ECO:0000269|PubMed:28656349"; MUTAGEN 152; /note="A->G: Promotes activation by S-(+)-carvone; when associated with G-108."; /evidence="ECO:0000269|PubMed:28656349"; MUTAGEN 257..258; /note="MY->AF: Abolished activation by (-)-carvone."; /evidence="ECO:0000269|PubMed:30639733
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15598656
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
28656349
uniprot
proteins
pubmed
30639733
uniprot
proteins
sequence_length
313
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15598656}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 26..46; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 58..78; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 86..106; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 132..152; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 198..218; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 239..259; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 270..290; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins