ELAVL4
entrez
1996
canonical
uniprot
P26378
canonical
ensembl
ENSG00000162374
resolver
ensp
ENSP00000349594
resolver
ensp
ENSP00000360884
resolver
ensp
ENSP00000360886
resolver
ensp
ENSP00000360888
resolver
ensp
ENSP00000360889
resolver
ensp
ENSP00000360892
resolver
ensp
ENSP00000399939
resolver
ensp
ENSP00000498318
resolver
ensp
ENSP00000498618
resolver
ensp
ENSP00000498865
resolver
ensp
ENSP00000498979
resolver
enst
ENST00000357083
resolver
enst
ENST00000371819
resolver
enst
ENST00000650764
resolver
enst
ENST00000651347
resolver
enst
ENST00000652693
resolver
genesymbol
ELAVL4
resolver
genesymbol_syn
HUD
resolver
genesymbol_syn
PNEM
resolver
hgnc
HGNC:3315
resolver
uniprot
A0A0R4J2E6
resolver
uniprot
A0A494C0M6
resolver
uniprot
A0A494C147
resolver
uniprot
A0A494C1D9
resolver
uniprot
B1APY6
resolver
uniprot
B1APY7
resolver
uniprot
B1APY8
resolver
uniprot
B1APY9
resolver
uniprot
B7Z4G7
resolver
uniprot
B7Z5G3
resolver
uniprot
Q8IYD4
resolver
uniprot
Q96J74
resolver
uniprot
Q96J75
resolver
uniprot
Q9UD24
resolver
uniprot_entry
A0A0R4J2E6_HUMAN
resolver
uniprot_entry
A0A494C0M6_HUMAN
resolver
uniprot_entry
A0A494C147_HUMAN
resolver
uniprot_entry
A0A494C1D9_HUMAN
resolver
uniprot_entry
B1APY9_HUMAN
resolver
uniprot_entry
B7Z5G3_HUMAN
resolver
uniprot_entry
ELAV4_HUMAN
resolver
uniprot_sec
B1APY6
resolver
uniprot_sec
B1APY7
resolver
uniprot_sec
B1APY8
resolver
uniprot_sec
B7Z4G7
resolver
uniprot_sec
Q8IYD4
resolver
uniprot_sec
Q96J74
resolver
uniprot_sec
Q96J75
resolver
uniprot_sec
Q9UD24
resolver
amino_acid_sequence
MEWNGLKMIISTMEPQVSNGPTSNTSNGPSSNNRNCPSPMQTGATTDDSKTNLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINTLNGLRLQTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPSGATEPITVKFANNPSQKSSQALLSQLYQSPNRRYPGPLHHQAQRFRLDNLLNMAYGVKRLMSGPVPPSACPPRFSPITIDGMTSLVGMNIPGHTGTGWCIFVYNLSPDSDESVLWQLFGPFGAVNNVKVIRDFNTNKCKGFGFVTMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKAHKS
uniprot
proteins
function
FUNCTION: RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs (PubMed:10710437, PubMed:12034726, PubMed:12468554, PubMed:17035636, PubMed:17234598, PubMed:7898713). Plays a role in the regulation of mRNA stability, alternative splicing and translation (PubMed:10710437, PubMed:12034726, PubMed:12468554, PubMed:17035636, PubMed:17234598, PubMed:7898713). Binds to AU-rich element (ARE) sequences in the 3' untranslated region (UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA (PubMed:10710437, PubMed:12034726, PubMed:12468554, PubMed:7898713). Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function (By similarity). By binding to the mRNA 3'UTR, decreases mRNA deadenylation and thereby contributes to the stabilization of mRNA molecules and their protection from decay (PubMed:12034726). Also binds to the polyadenylated (poly(A)) tail in the 3'UTR of mRNA, thereby increasing its affinity for mRNA binding (PubMed:12034726). Mainly plays a role in neuron-specific RNA processing by stabilization of mRNAs such as GAP43, ACHE and mRNAs of other neuronal proteins, thereby contributing to the differentiation of neural progenitor cells, nervous system development, learning and memory mechanisms (PubMed:12034726, PubMed:12468554, PubMed:17234598, PubMed:18218628). Involved in the negative regulation of the proliferative activity of neuronal stem cells and in the positive regulation of neuronal differentiation of neural progenitor cells (By similarity). Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone of the hippocampus by binding to and stabilizing SATB1 mRNA (By similarity). Binds and stabilizes MSI1 mRNA in neural stem cells (By similarity). Exhibits increased binding to ACHE mRNA during neuronal differentiation, thereby stabilizing ACHE mRNA and enhancing its expression (PubMed:12468554, PubMed:17234598). Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity). May bind to APP and BACE1 mRNAS and the BACE1AS lncRNA and enhance their stabilization (PubMed:24857657). Plays a role in neurite outgrowth and in the establishment and maturation of dendritic arbors, thereby contributing to neocortical and hippocampal circuitry function (By similarity). Stabilizes GAP43 mRNA and protects it from decay during postembryonic development in the brain (PubMed:12034726). By promoting the stabilization of GAP43 mRNA, plays a role in NGF-mediated neurite outgrowth (By similarity). Binds to BDNF long 3'UTR mRNA, thereby leading to its stabilization and increased dendritic translation after activation of PKC (By similarity). By increasing translation of BDNF after nerve injury, may contribute to nerve regeneration (By similarity). Acts as a stabilizing factor by binding to the 3'UTR of NOVA1 mRNA, thereby increasing its translation and enhancing its functional activity in neuron-specific splicing (PubMed:18218628). Stimulates translation of mRNA in a poly(A)- and cap-dependent manner, possibly by associating with the EIF4F cap-binding complex (By similarity). May also negatively regulate translation by binding to the 5'UTR of Ins2 mRNA, thereby repressing its translation (By similarity). Upon glucose stimulation, Ins2 mRNA is released from ELAVL4 and translational inhibition is abolished (By similarity). Also plays a role in the regulation of alternative splicing (PubMed:17035636). May regulate alternative splicing of CALCA pre-mRNA into Calcitonin and Calcitonin gene-related peptide 1 (CGRP) by competing with splicing regulator TIAR for binding to U-rich intronic sequences of CALCA pre-mRNA (PubMed:17035636). {ECO:0000250|UniProtKB:O09032, ECO:0000250|UniProtKB:Q61701, ECO:0000269|PubMed:10710437, ECO:0000269|PubMed:12034726, ECO:0000269|PubMed:12468554, ECO:0000269|PubMed:17035636, ECO:0000269|PubMed:17234598, ECO:0000269|PubMed:18218628, ECO:0000269|PubMed:24857657, ECO:0000269|PubMed:7898713}.
uniprot
proteins
mass_dalton
42398
uniprot
proteins
post_translational_modification
PTM: Methylated by CARM1, which leads to reduced RNA-binding activity and enhanced interaction with SMN (PubMed:21088113). Methylation at Arg-248 by CARM1 weakens protective binding to the 3'UTR of CDKN1A mRNA and down-regulates CDKN1A protein expression, thereby maintaining cells in a proliferative state (By similarity). Methylation is inhibited by NGF, which facilitates neurite outgrowth (By similarity). {ECO:0000250|UniProtKB:O09032, ECO:0000269|PubMed:21088113}.
uniprot
proteins
protein_family
RRM elav family
uniprot
proteins
pubmed
10710437
uniprot
proteins
pubmed
11175903
uniprot
proteins
pubmed
12034726
uniprot
proteins
pubmed
12209604
uniprot
proteins
pubmed
12468554
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16508003
uniprot
proteins
pubmed
1655278
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17035636
uniprot
proteins
pubmed
17234598
uniprot
proteins
pubmed
18218628
uniprot
proteins
pubmed
21088113
uniprot
proteins
pubmed
21389246
uniprot
proteins
pubmed
22387028
uniprot
proteins
pubmed
24857657
uniprot
proteins
pubmed
29061699
uniprot
proteins
pubmed
7898713
uniprot
proteins
sequence_length
385
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21088113}. Perikaryon {ECO:0000250|UniProtKB:O09032}. Cell projection, dendrite {ECO:0000250|UniProtKB:O09032}. Cell projection, axon {ECO:0000250|UniProtKB:Q61701}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q61701}. Note=Co-localizes with ribosomal RNA in polysomes. {ECO:0000250|UniProtKB:O09032}.
uniprot
proteins