Slco2b1
entrez
140860
canonical
uniprot
Q9JHI3
canonical
ensembl
ENSRNOG00000017976
resolver
ensp
ENSRNOP00000024281
resolver
ensp
ENSRNOP00000074504
resolver
ensp
ENSRNOP00000097657
resolver
enst
ENSRNOT00000091807
resolver
enst
ENSRNOT00000095615
resolver
genesymbol
Slco2b1
resolver
genesymbol_syn
Oatp2b1
resolver
genesymbol_syn
Slc21a9
resolver
uniprot
A0A0G2K880
resolver
uniprot
A0A8I6AV99
resolver
uniprot_entry
A0A0G2K880_RAT
resolver
uniprot_entry
A0A8I6AV99_RAT
resolver
uniprot_entry
SO2B1_RAT
resolver
amino_acid_sequence
MPDRSTKATMGAEDIHERKVSMEPRDSHQDAQPRGMFQNIKFFVLCHSILQLAQLMISGYLKSSISTVEKRFGLSSQTSGLLAAFNEVGNISLILFVSYFGSRVHRPRMIGCGAILVAVAGLLMALPHFISEPYRYDHSSPDRSQDFEASLCLPTTMAPASALSNDSCSSRTETKHLTMVGIMFTAQTLLGIGGVPIQPFGISYIDDFAHHSNSPLYLGILFAITMMGPGLAYGLGSLMLRLYVDIDRMPEGGINLTTKDPRWVGAWWLGFLISAGLVVLAASPYFFFPREMPKEKYELHFRQKVLAGGASIGSKGEELSSQHEPLKKQAGLPQIAPDLTVVQFIKVFPRVLLRTLRHPIFLLVVLSQVCTSSMVAGTATFLPKFLERQFSITASFANLLLGCLTIPLAIVGIVVGGVLVKRLHLSPMQCSALCLLGSLLCLLLSLPLFFIGCSTHHIAGITQDLGAQPGPSLFPGCSEPCSCQSDDFNPVCDTSAYVEYTTPCHAGCTGRVVQEALDKSQVFYTNCSCVAGNGTISAGSCESACSRLVLPFILLISLGAAVASITHTPSFMLILRGVKKEDKTLAVGMQFMLLRVLAWMPSPVIHGSAIDTTCVHWALTCGRRAVCRYYDHDLLRNRFIGLQFFFKSGSLVCFALVLAILRQQSREASTKATVKSSDLQEL
uniprot
proteins
function
FUNCTION: Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins D2 (PGD2), E1 (PGE1) and E2 (PGE2), leukotriene C4, thromboxane B2 and L-thyroxine (PubMed:10973807). Also plays a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons. May act as a heme transporter that promotes cellular iron availability. Also transports heme by-product coproporphyrin III (CPIII), and may be involved in their hepatic disposition (By similarity). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (By similarity). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment. The exact transport mechanism has not been yet deciphered but most likely involves an anion exchange, coupling the cellular uptake of organic substrate with the efflux of an anionic compound. Hydrogencarbonate/HCO3(-) acts as a probable counteranion that exchanges for organic anions. Cytoplasmic glutamate may also act as counteranion in the placenta (By similarity). {ECO:0000250|UniProtKB:O94956, ECO:0000269|PubMed:10973807}.
uniprot
proteins
mass_dalton
74215
uniprot
proteins
protein_family
Organo anion transporter (TC 2.A.60) family
uniprot
proteins
pubmed
10973807
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
34628357
uniprot
proteins
sequence_length
682
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O94956}; Multi-pass membrane protein {ECO:0000305}. Basal cell membrane {ECO:0000250|UniProtKB:O94956}; Multi-pass membrane protein {ECO:0000305}. Apical cell membrane {ECO:0000250|UniProtKB:O94956}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 42..61; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 81..101; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 108..132; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 177..206; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 226..246; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 265..289; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 355..376; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 397..420; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 425..448; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 553..575; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 585..610; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 644..661; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins