TEKT3
entrez
64518
canonical
uniprot
Q9BXF9
canonical
ensembl
ENSG00000125409
resolver
ensp
ENSP00000343995
resolver
ensp
ENSP00000379263
resolver
enst
ENST00000338696
resolver
enst
ENST00000395930
resolver
genesymbol
TEKT3
resolver
hgnc
HGNC:14293
resolver
uniprot
B2RAS7
resolver
uniprot
D3DTT0
resolver
uniprot
Q8N5R5
resolver
uniprot
Q96M48
resolver
uniprot_entry
TEKT3_HUMAN
resolver
uniprot_sec
B2RAS7
resolver
uniprot_sec
D3DTT0
resolver
uniprot_sec
Q8N5R5
resolver
uniprot_sec
Q96M48
resolver
amino_acid_sequence
MERVGCTLTTTYAHPRPTPTNFLPAISTMASSYRDRFPHSNLTHSLSLPWRPSTYYKVASNSPSVAPYCTRSQRVSENTMLPFVSNRTTFFTRYTPDDWYRSNLTNYQESNTSRHNSEKLRVDTSRLIQDKYQQTRKTQADTTQNLGERVNDIGFWKSEIIHELDEMIGETNALTDVKKRLERALMETEAPLQVARECLFHREKRMGIDLVHDEVEAQLLTEVDTILCCQERMKLHLDKAIAQLAANRASQHELEKDLSDKQTAYRIDDKCHHLRNTSDGVGYFRGVERVDATVSVPESWAKFTDDNILRSQSERAASAKLRDDIENLLVVTANEMWNQFNKVNLSFTNRIAETADAKNKIQTHLAKTLQEIFQTEMTIESIKKAIKDKTAFLKVAQTRLDERTRRPNIELCRDMAQLRLVNEVHEVDDTIQTLQQRLRDAEDTLQSLVHIKATLEYDLAVKANSLYIDQEKCMSMRKSYPNTLRLVGFC
uniprot
proteins
disease_involvement
DISEASE: Spermatogenic failure 81 (SPGF81) [MIM:620277]: A male infertility disorder due to oligoasthenoteratozoospermia and characterized by reduced progressive sperm motility. Patient spermatozoa exhibit acrosomal hypoplasia and detachment of the acrosome from the sperm head. {ECO:0000269|PubMed:36708031}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme (PubMed:36191189). Forms filamentous polymers in the walls of ciliary and flagellar microtubules (By similarity). Required for normal sperm mobility (By similarity). {ECO:0000250|UniProtKB:A6H782, ECO:0000250|UniProtKB:Q6X6Z7, ECO:0000269|PubMed:36191189}.
uniprot
proteins
mass_dalton
56636
uniprot
proteins
post_translational_modification
PTM: N- and O-glycosylated. {ECO:0000250|UniProtKB:A6H782}.; PTM: May be proteolytically processed during the epididymal transit of spermatozoa. {ECO:0000250|UniProtKB:A6H782}.; PTM: Ubiquitinated, leading to its degradation. Deubiquitinated by USP16, promoting its stability. {ECO:0000250|UniProtKB:Q6X6Z7}.
uniprot
proteins
protein_family
Tektin family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
36191189
uniprot
proteins
pubmed
36708031
uniprot
proteins
sequence_length
490
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:36191189}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:36708031}. Cytoplasmic vesicle, secretory vesicle, acrosome outer membrane {ECO:0000250|UniProtKB:A6H782, ECO:0000250|UniProtKB:Q4V8G8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q4V8G8}. Note=In spermatozoa, preferentially localizes to the flagella, but also found in the head (PubMed:36708031). In the sperm flagellum, localizes to the periaxonemal region where it associates with the mitochondrial sheath and outer dense fibers (By similarity). Not detected in the central axonemal region of the flagellum (By similarity). Associates with the acrosome membrane in the equatorial segment of the sperm head (By similarity). Also detected just below the plasma membrane in the post-acrosomal region where it might localize to the postacrosomal dense lamina (By similarity). However, other studies report little or no expression in the postacrosomal region (By similarity). Translocates from the postacrosomal region to the equatorial segment after sperm activation (By similarity). Retained in the postacromal region, but not the equatorial segment, following the acrosome reaction (By similarity). Some studies report strong expression in the anterior cap region (By similarity). However, other studies report little or no expression in the acrosomal cap (By similarity). {ECO:0000250|UniProtKB:A6H782, ECO:0000250|UniProtKB:Q4V8G8, ECO:0000269|PubMed:36708031}.
uniprot
proteins