MAOA
entrez
4128
canonical
uniprot
P21397
canonical
ensembl
ENSG00000189221
resolver
ensp
ENSP00000340684
resolver
ensp
ENSP00000440846
resolver
genesymbol
MAOA
resolver
hgnc
HGNC:6833
resolver
uniprot
B4DF46
resolver
uniprot
Q16426
resolver
uniprot
Q49A63
resolver
uniprot
Q53YE7
resolver
uniprot_entry
AOFA_HUMAN
resolver
uniprot_entry
Q49A63_HUMAN
resolver
uniprot_entry
Q53YE7_HUMAN
resolver
uniprot_sec
B4DF46
resolver
uniprot_sec
Q16426
resolver
amino_acid_sequence
MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
uniprot
proteins
disease_involvement
DISEASE: Brunner syndrome (BRNRS) [MIM:300615]: A form of X-linked non-dysmorphic mild intellectual disability. Male patients are affected by borderline intellectual deficit and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior. {ECO:0000269|PubMed:8211186}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
1.4.3.21
uniprot
proteins
ec_number
1.4.3.4
uniprot
proteins
function
FUNCTION: Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:18391214, PubMed:20493079, PubMed:24169519, PubMed:8316221). Preferentially oxidizes serotonin (PubMed:20493079, PubMed:24169519). Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline (By similarity). {ECO:0000250|UniProtKB:P21396, ECO:0000269|PubMed:18391214, ECO:0000269|PubMed:20493079, ECO:0000269|PubMed:24169519, ECO:0000269|PubMed:8316221}.
uniprot
proteins
mass_dalton
59682
uniprot
proteins
mutagenesis
MUTAGEN 165; /note="C->S: No loss of activity."; /evidence="ECO:0000269|PubMed:8316221"; MUTAGEN 266; /note="C->S: No loss of activity."; /evidence="ECO:0000269|PubMed:8316221"; MUTAGEN 306; /note="C->S: No loss of activity."; /evidence="ECO:0000269|PubMed:8316221"; MUTAGEN 321; /note="C->S: No loss of activity."; /evidence="ECO:0000269|PubMed:8316221"; MUTAGEN 323; /note="C->S: No loss of activity."; /evidence="ECO:0000269|PubMed:8316221"; MUTAGEN 374; /note="C->S: Complete loss of activity."; /evidence="ECO:0000269|PubMed:8316221"; MUTAGEN 398; /note="C->S: No loss of activity."; /evidence="ECO:0000269|PubMed:8316221"; MUTAGEN 406; /note="C->S: Complete loss of activity."; /evidence="ECO:0000269|PubMed:8316221
uniprot
proteins
protein_family
Flavin monoamine oxidase family
uniprot
proteins
pubmed
11812236
uniprot
proteins
pubmed
1432104
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
16129825
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
18391214
uniprot
proteins
pubmed
1886775
uniprot
proteins
pubmed
2023912
uniprot
proteins
pubmed
20493079
uniprot
proteins
pubmed
21179162
uniprot
proteins
pubmed
24169519
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2764901
uniprot
proteins
pubmed
3178846
uniprot
proteins
pubmed
3387449
uniprot
proteins
pubmed
3418353
uniprot
proteins
pubmed
7519662
uniprot
proteins
pubmed
8211186
uniprot
proteins
pubmed
8316221
uniprot
proteins
pubmed
8584674
uniprot
proteins
pubmed
9799080
uniprot
proteins
sequence_length
527
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:P21396}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:P21396}; Cytoplasmic side {ECO:0000250|UniProtKB:P21396}.
uniprot
proteins
transmembrane_region
TRANSMEM 498..518; /note="Helical; Anchor for type IV membrane protein
uniprot
proteins