Pxn
entrez
19303
canonical
uniprot
Q8VI36
canonical
ensembl
ENSMUSG00000029528
resolver
ensp
ENSMUSP00000069624
resolver
ensp
ENSMUSP00000083709
resolver
ensp
ENSMUSP00000144459
resolver
ensp
ENSMUSP00000188573
resolver
ensp
ENSMUSP00000188574
resolver
ensp
ENSMUSP00000188575
resolver
ensp
ENSMUSP00000188582
resolver
enst
ENSMUST00000086523
resolver
enst
ENSMUST00000202564
resolver
genesymbol
Pxn
resolver
uniprot
A0A0J9YV30
resolver
uniprot
F8VQ28
resolver
uniprot
Q3TB62
resolver
uniprot
Q3TZQ6
resolver
uniprot
Q8VI37
resolver
uniprot_entry
A0A0J9YV30_MOUSE
resolver
uniprot_entry
F8VQ28_MOUSE
resolver
uniprot_entry
PAXI_MOUSE
resolver
uniprot_sec
Q3TB62
resolver
uniprot_sec
Q3TZQ6
resolver
uniprot_sec
Q8VI37
resolver
amino_acid_sequence
MDDLDALLADLESTTSHISKRPVFLSEEPPYSYPTGNHTYQEIAVPPPVPPPPSSEALNGTVLDPLDQWQPSGSRYAHQQPPSPLPVYSSSAKNSSASNTQDGVGSLCSRAGEEEHVYSFPNKQKSAEPSPTVMSSSLGSNLSELDRLLLELNAVQHSPPGFPADEAESSPPLPGALSPLYGIPENNTPLGGKAGPLVKEKPKRNGGRGLEDVRPSVESLLDELESSVPSPVPAITVNQGEMSSPQRVTSSQQQTRISASSATRELDELMASLSDFKMQGLEQRVDGERPWAAGWPPSSRQSSPEGQDEGGFMAQGKTGSSSPPGGLSKPGSQLDSMLGSLQSDLNKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHSLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQSCFVKLFC
uniprot
proteins
function
FUNCTION: Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Recruits other proteins such as TRIM15 to focal adhesion. {ECO:0000250|UniProtKB:P49023}.
uniprot
proteins
mass_dalton
64476
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MAPK1/ERK2. Phosphorylated on tyrosine residues during integrin-mediated cell adhesion, embryonic development, fibroblast transformation and following stimulation of cells by mitogens. Phosphorylation at Ser-244 by CDK5 reduces its interaction with PTK2/FAK1 in matrix-cell focal adhesions (MCFA) during oligodendrocytes (OLs) differentiation (By similarity). Phosphorylation at Tyr-31 and Tyr-118 by PTK6 promote the activation of RAC1 via CRK/CrKII, thereby promoting migration and invasion (By similarity). Phosphorylation at Ser-250 by SLK is required for PXN redistribution and cell motility (By similarity). Phosphorylation at Ser-272 promotes focal adhesion disassembly during cell migration (By similarity). {ECO:0000250|UniProtKB:P49023}.
uniprot
proteins
protein_family
Paxillin family
uniprot
proteins
pubmed
10753946
uniprot
proteins
pubmed
11134073
uniprot
proteins
pubmed
11799401
uniprot
proteins
pubmed
11805099
uniprot
proteins
pubmed
11825902
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21430700
uniprot
proteins
pubmed
8940124
uniprot
proteins
sequence_length
591
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:P49023}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P49023}. Cytoplasm, cell cortex {ECO:0000269|PubMed:8940124}. Note=Colocalizes with integrins at the cell periphery. Colocalizes with PXN to membrane ruffles and the leading edge of migrating cells (By similarity). {ECO:0000250|UniProtKB:P49023}.
uniprot
proteins