SLC37A3
entrez
84255
canonical
uniprot
Q8NCC5
canonical
ensembl
ENSG00000157800
resolver
ensp
ENSP00000321498
resolver
ensp
ENSP00000343358
resolver
ensp
ENSP00000397481
resolver
ensp
ENSP00000607975
resolver
ensp
ENSP00000622763
resolver
ensp
ENSP00000666911
resolver
ensp
ENSP00000666912
resolver
genesymbol
SLC37A3
resolver
genesymbol_syn
SPX3
resolver
hgnc
HGNC:20651
resolver
uniprot
Q6PIU7
resolver
uniprot
Q86SS4
resolver
uniprot
Q9BQG7
resolver
uniprot_entry
SPX3_HUMAN
resolver
uniprot_sec
Q6PIU7
resolver
uniprot_sec
Q86SS4
resolver
uniprot_sec
Q9BQG7
resolver
amino_acid_sequence
MAWPNVFQRGSLLSQFSHHHVVVFLLTFFSYSLLHASRKTFSNVKVSISEQWTPSAFNTSVELPVEIWSSNHLFPSAEKATLFLGTLDTIFLFSYAVGLFISGIVGDRLNLRWVLSFGMCSSALVVFVFGALTEWLRFYNKWLYCCLWIVNGLLQSTGWPCVVAVMGNWFGKAGRGVVFGLWSACASVGNILGACLASSVLQYGYEYAFLVTASVQFAGGIVIFFGLLVSPEEIGLSGIEAEENFEEDSHRPLINGGENEDEYEPNYSIQDDSSVAQVKAISFYQACCLPGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFGWKEAEADKLSIWYDVGGIIGGTLQGFISDVLQKRAPVLALSLLLAVGSLIGYSRSPNDKSINALLMTVTGFFIGGPSNMISSAISADLGRQELIQRSSEALATVTGIVDGSGSIGAAVGQYLVSLIRDKLGWMWVFYFFILMTSCTIVFISPLIVREIFSLVLRRQAHILRE
uniprot
proteins
function
FUNCTION: Unlike the other SLC37 members, lacks glucose-6-phosphate antiporter activity (PubMed:21949678). In osteoclasts, forms a transporter complex with ATRAID for nitrogen-containing-bisphosphonates (N-BPs) required for releasing N-BP molecules that have trafficked to lysosomes through fluid-phase endocytosis into the cytosol (PubMed:29745899). {ECO:0000269|PubMed:21949678, ECO:0000269|PubMed:29745899}.
uniprot
proteins
mass_dalton
54486
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:29745899}.
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21949678
uniprot
proteins
pubmed
29745899
uniprot
proteins
sequence_length
494
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21949678}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000269|PubMed:29745899}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 16..36; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 81..101; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 113..133; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 147..167; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 177..197; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 209..229; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 297..317; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 333..353; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 357..377; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 386..406; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 428..448; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 452..472; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins