LRRC58
entrez
116064
canonical
uniprot
Q96CX6
canonical
ensembl
ENSG00000163428
resolver
ensp
ENSP00000295628
resolver
ensp
ENSP00000797879
resolver
enst
ENST00000295628
resolver
genesymbol
LRRC58
resolver
hgnc
HGNC:26968
resolver
uniprot_entry
LRC58_HUMAN
resolver
amino_acid_sequence
MEEAGAAVVTAGEAELNWSRLSVSTETLESELEARGEERRGAREALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLVVRFVRDLTYDPPTLLELAARTIKIRNISYTPYDLPGNLLRYLGSASNCPNPKCGGVYFDCCVRQIKFVDFCGKYRLPLMHYLCSPECSSPCSSASHSSTSQSESDSEDEASVAARRMQKVLLG
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CDO1 (PubMed:40963025). The ECS(LRRC58) complex acts as a regulator of cysteine catabolism by mediating ubiquitination and degradation of CDO1, the rate-limiting enzyme of the cysteine catabolic process to taurine (PubMed:40963025). L-cysteine abundance regulates ECS(LRRC58)-mediated ubiquitination of CDO1: the complex promotes ubiquitination and degradation of CDO1 in presence of high level of cysteine, but not when cysteine abundance is low (PubMed:40963025). {ECO:0000269|PubMed:40963025}.
uniprot
proteins
mass_dalton
40586
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:40963025}.
uniprot
proteins
protein_family
LRRC58 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
40963025
uniprot
proteins
sequence_length
371
uniprot
proteins