Blvrb
entrez
233016
canonical
uniprot
Q923D2
canonical
ensembl
ENSMUSG00000040466
resolver
ensp
ENSMUSP00000043092
resolver
ensp
ENSMUSP00000103994
resolver
enst
ENSMUST00000037399
resolver
enst
ENSMUST00000108357
resolver
genesymbol
Blvrb
resolver
genesymbol_syn
Scan
resolver
uniprot
E9PZC4
resolver
uniprot
Q3U6G1
resolver
uniprot_entry
BLVRB_MOUSE
resolver
uniprot_entry
E9PZC4_MOUSE
resolver
uniprot_entry
Q3U6G1_MOUSE
resolver
amino_acid_sequence
MTVKKIAIFGATGRTGLTTLAQAVQAGYEVTVLVRDSSRLPSEGPQPAHVVVGDVRQAADVDKTVAGQEAVIVLLGTGNDLSPTTVMSEGTRNIVTAMKAHGVDKVVACTSAFLLWDPTKVPPRLQDVTDDHIRMHKILQESGLKYVAVMPPHIGDQPLTGAYTVTLDGRGPSRVISKHDLGHFMLRCLTTNEYDGHTTYPSHQYD
uniprot
proteins
ec_number
1.3.1.-
uniprot
proteins
ec_number
1.5.1.30
uniprot
proteins
ec_number
2.6.99.-
uniprot
proteins
function
FUNCTION: Enzyme that can both act as a NAD(P)H-dependent reductase and a S-nitroso-CoA-dependent nitrosyltransferase (PubMed:38056462). Promotes fetal heme degradation during development (By similarity). Also expressed in adult tissues, where it acts as a regulator of hematopoiesis, intermediary metabolism (glutaminolysis, glycolysis, TCA cycle and pentose phosphate pathway) and insulin signaling (PubMed:33359909, PubMed:38056462). Has a broad specificity oxidoreductase activity by catalyzing the NAD(P)H-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone) (By similarity). Contributes to fetal heme catabolism by catalyzing reduction of biliverdin IXbeta into bilirubin IXbeta in the liver (By similarity). Biliverdin IXbeta, which constitutes the major heme catabolite in the fetus is not present in adult (By similarity). Does not reduce bilirubin IXalpha (By similarity). Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH (By similarity). Acts as a protein nitrosyltransferase by catalyzing nitrosylation of cysteine residues of target proteins, such as HMOX2, INSR and IRS1 (PubMed:38056462). S-nitroso-CoA-dependent nitrosyltransferase activity is mediated via a 'ping-pong' mechanism: BLVRB first associates with both S-nitroso-CoA and protein substrate, nitric oxide group is then transferred from S-nitroso-CoA to Cys-109 and Cys-188 residues of BLVRB and from S-nitroso-BLVRB to the protein substrate (By similarity). Inhibits insulin signaling by mediating nitrosylation of INSR and IRS1, leading to their inhibition (PubMed:38056462). {ECO:0000250|UniProtKB:P30043, ECO:0000269|PubMed:33359909, ECO:0000269|PubMed:38056462}.
uniprot
proteins
mass_dalton
22197
uniprot
proteins
protein_family
BLVRB family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
33359909
uniprot
proteins
pubmed
38056462
uniprot
proteins
sequence_length
206
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P30043}.
uniprot
proteins