TSSK4
entrez
283629
canonical
uniprot
Q6SA08
canonical
ensembl
ENSG00000139908
resolver
ensembl
ENSG00000285140
resolver
ensp
ENSP00000287913
resolver
ensp
ENSP00000339179
resolver
ensp
ENSP00000452054
resolver
genesymbol
TSSK4
resolver
genesymbol_syn
C14orf20
resolver
genesymbol_syn
STK22E
resolver
genesymbol_syn
TSSK5
resolver
hgnc
HGNC:19825
resolver
uniprot
Q2TA60
resolver
uniprot
Q6ZNM2
resolver
uniprot_entry
TSSK4_HUMAN
resolver
uniprot_sec
Q2TA60
resolver
uniprot_sec
Q6ZNM2
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation on Thr-197. {ECO:0000250|UniProtKB:Q9D411}.
uniprot
proteins
amino_acid_sequence
MGKGDVLEAAPTTTAYHSLMDEYGYEVGKAIGHGSYGSVYEAFYTKQKVMVAVKIISKKKASDDYLNKFLPREIQVMKVLRHKYLINFYRAIESTSRVYIILELAQGGDVLEWIQRYGACSEPLAGKWFSQLTLGIAYLHSKSIVHRDLKLENLLLDKWENVKISDFGFAKMVPSNQPVGCSPSYRQVNCFSHLSQTYCGSFAYACPEILRGLPYNPFLSDTWSMGVILYTLVVAHLPFDDTNLKKLLRETQKEVTFPANHTISQECKNLILQMLRQATKRATILDIIKDSWVLKFQPEQPTHEIRLLEAMCQLHNTTKQHQSLQITT
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine kinase which is involved in male germ cell development and in mature sperm function (By similarity). May be involved in the Cre/Creb signaling pathway (By similarity). Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells (PubMed:15964553). Phosphorylates CREM on 'Ser-116' in vitro (By similarity). Phosphorylates ODF2 on 'Ser-95' (By similarity). {ECO:0000250|UniProtKB:Q9D411, ECO:0000269|PubMed:15964553}.
uniprot
proteins
mass_dalton
37454
uniprot
proteins
mutagenesis
MUTAGEN 54; /note="K->M: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:15964553
uniprot
proteins
post_translational_modification
PTM: Activated by autophosphorylation on Thr-197. ODF2 potentiates the autophosphorylation activity of TSSK4 at Thr-197. {ECO:0000250|UniProtKB:Q9D411}.; PTM: Ubiquitinated; HSP90 activity negatively regulates ubiquitination and degradation. {ECO:0000250|UniProtKB:Q9D411}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15964553
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
30683861
uniprot
proteins
sequence_length
328
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q9D411}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9D411}. Note=In spermatozoa, present in the sperm head and in the flagellum. {ECO:0000250|UniProtKB:Q9D411}.
uniprot
proteins