CD160
entrez
11126
canonical
uniprot
O95971
canonical
ensembl
ENSG00000117281
resolver
ensp
ENSP00000358294
resolver
ensp
ENSP00000385199
resolver
genesymbol
CD160
resolver
genesymbol_syn
BY55
resolver
hgnc
HGNC:17013
resolver
uniprot
A0A0B4J2A1
resolver
uniprot
B8PRF2
resolver
uniprot
Q5T2V6
resolver
uniprot
Q6FH89
resolver
uniprot_entry
BY55_HUMAN
resolver
uniprot_entry
Q6FH89_HUMAN
resolver
uniprot_sec
A0A0B4J2A1
resolver
uniprot_sec
B8PRF2
resolver
uniprot_sec
Q5T2V6
resolver
amino_acid_sequence
MLLEPGRGCCALAILLAIVDIQSGGCINITSSASQEGTRLNLICTVWHKKEEAEGFVVFLCKDRSGDCSPETSLKQLRLKRDPGIDGVGEISSQLMFTISQVTPLHSGTYQCCARSQKSGIRLQGHFFSILFTETGNYTVTGLKQRQHLEFSHNEGTLSSGFLQEKVWVMLVTSLVALQAL
uniprot
proteins
function
FUNCTION: [CD160 antigen]: Receptor on immune cells capable to deliver stimulatory or inhibitory signals that regulate cell activation and differentiation. Exists as a GPI-anchored and as a transmembrane form, each likely initiating distinct signaling pathways via phosphoinositol 3-kinase in activated NK cells and via LCK and CD247/CD3 zeta chain in activated T cells (PubMed:11978774, PubMed:17307798, PubMed:19109136). Receptor for both classical and non-classical MHC class I molecules (PubMed:12486241, PubMed:9973372). In the context of acute viral infection, recognizes HLA-C and triggers NK cell cytotoxic activity, likely playing a role in anti-viral innate immune response (PubMed:12486241). On CD8+ T cells, binds HLA-A2-B2M in complex with a viral peptide and provides a costimulatory signal to activated/memory T cells (PubMed:9973372). Upon persistent antigen stimulation, such as occurs during chronic viral infection, may progressively inhibit TCR signaling in memory CD8+ T cells, contributing to T cell exhaustion (PubMed:25255144). On endothelial cells, recognizes HLA-G and controls angiogenesis in immune privileged sites (PubMed:16809620). Receptor or ligand for TNF superfamily member TNFRSF14, participating in bidirectional cell-cell contact signaling between antigen presenting cells and lymphocytes. Upon ligation of TNFRSF14, provides stimulatory signal to NK cells enhancing IFNG production and anti-tumor immune response (By similarity). On activated CD4+ T cells, interacts with TNFRSF14 and down-regulates CD28 costimulatory signaling, restricting memory and alloantigen-specific immune response (PubMed:18193050). In the context of bacterial infection, acts as a ligand for TNFRSF14 on epithelial cells, triggering the production of antimicrobial proteins and pro-inflammatory cytokines (By similarity). {ECO:0000250|UniProtKB:O88875, ECO:0000269|PubMed:11978774, ECO:0000269|PubMed:12486241, ECO:0000269|PubMed:16809620, ECO:0000269|PubMed:17307798, ECO:0000269|PubMed:18193050, ECO:0000269|PubMed:19109136, ECO:0000269|PubMed:25255144, ECO:0000269|PubMed:9973372}.; FUNCTION: [CD160 antigen, soluble form]: The soluble GPI-cleaved form, usually released by activated lymphocytes, might play an immune regulatory role by limiting lymphocyte effector functions. {ECO:0000269|PubMed:17237375}.
uniprot
proteins
mass_dalton
19810
uniprot
proteins
pubmed
11978774
uniprot
proteins
pubmed
12486241
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16809620
uniprot
proteins
pubmed
17237375
uniprot
proteins
pubmed
17307798
uniprot
proteins
pubmed
18193050
uniprot
proteins
pubmed
19109136
uniprot
proteins
pubmed
23761635
uniprot
proteins
pubmed
25255144
uniprot
proteins
pubmed
9743336
uniprot
proteins
pubmed
9973372
uniprot
proteins
sequence_length
181
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [CD160 antigen]: Cell membrane {ECO:0000269|PubMed:12486241, ECO:0000269|PubMed:18193050, ECO:0000269|PubMed:9973372}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:23761635, ECO:0000269|PubMed:9743336}.; SUBCELLULAR LOCATION: [CD160 antigen, soluble form]: Secreted. Note=Released from the cell membrane by GPI cleavage. {ECO:0000269|PubMed:17237375, ECO:0000269|PubMed:23761635, ECO:0000269|PubMed:9743336}.
uniprot
proteins