Glyr1
entrez
74022
canonical
uniprot
Q922P9
canonical
ensembl
ENSMUSG00000022536
resolver
ensp
ENSMUSP00000023189
resolver
ensp
ENSMUSP00000111510
resolver
ensp
ENSMUSP00000303287
resolver
ensp
ENSMUSP00000303290
resolver
ensp
ENSMUSP00000303339
resolver
enst
ENSMUST00000023189
resolver
enst
ENSMUST00000115844
resolver
genesymbol
Glyr1
resolver
genesymbol_syn
Np60
resolver
uniprot
D3YYT1
resolver
uniprot
Q3TX02
resolver
uniprot
Q9CYQ1
resolver
uniprot_entry
D3YYT1_MOUSE
resolver
uniprot_entry
GLYR1_MOUSE
resolver
uniprot_sec
Q3TX02
resolver
uniprot_sec
Q9CYQ1
resolver
amino_acid_sequence
MAAVSLRLGDLVWGKLGRYPPWPGKIVNPPKDLKKPRGKKCFFVKFFGTEDHAWIKVEQLKPYHAHKEEMIKINKGKRFQQAVDAVEEFLRRAKGKDQTSSHTSADDKNRRNSSEERSRPNSGDEKRKLSLSEGKVKKNMGEGKKRVTSGSADRGSKCLKRAQEQSPRKRGRPPKDEKDLTIPESSTVKGMMAGPMAAFKWQPTATEPVKDADPHFHHFLLSQTEKPAVCYQAITKKLKICEEETGSTSIQAADSTAVNGSITPTDKKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKEGARLGRTPAEVVSTCDITFACVSDPKAAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDCSSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEGLTLAQVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYIQKDLRLAIALGDAVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRAYIH
uniprot
proteins
function
FUNCTION: Cytokine-like nuclear factor with chromatin gene reader activity involved in chromatin modification and regulation of gene expression (PubMed:29759984). Acts as a nucleosome-destabilizing factor that is recruited to genes during transcriptional activation. Recognizes and binds histone H3 without a preference for specific epigenetic markers and also binds DNA. Interacts with KDM1B and promotes its histone demethylase activity by facilitating the capture of H3 tails, they form a multifunctional enzyme complex that modifies transcribed chromatin and facilitates Pol II transcription through nucleosomes. Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 (By similarity). With GATA4, co-binds a defined set of heart development genes and coregulates their expression during cardiomyocyte differentiation (PubMed:35182466). Regulates p38 MAP kinase activity by mediating stress activation of MAPK14/p38alpha and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 (By similarity). {ECO:0000250|UniProtKB:Q49A26, ECO:0000269|PubMed:29759984, ECO:0000269|PubMed:35182466}.
uniprot
proteins
mass_dalton
59716
uniprot
proteins
mutagenesis
MUTAGEN 489; /note="P->L: Mutant animals are born at expected Mendelian ratios. 54% mutants display postnatal lethality between days 0 and 1. They show centricular septal defects."; /evidence="ECO:0000269|PubMed:35182466
uniprot
proteins
protein_family
HIBADH-related family
uniprot
proteins
protein_family
NP60 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29759984
uniprot
proteins
pubmed
35182466
uniprot
proteins
sequence_length
546
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q49A26}. Chromosome {ECO:0000250|UniProtKB:Q49A26}. Note=Found in actively RNAPolII-transcribed gene bodies. {ECO:0000250|UniProtKB:Q49A26}.
uniprot
proteins