RECK
entrez
8434
canonical
uniprot
O95980
canonical
ensembl
ENSG00000122707
resolver
ensp
ENSP00000367202
resolver
ensp
ENSP00000670595
resolver
ensp
ENSP00000794722
resolver
enst
ENST00000377966
resolver
genesymbol
RECK
resolver
genesymbol_syn
ST15
resolver
hgnc
HGNC:11345
resolver
uniprot
A8K9D8
resolver
uniprot
B2RNS1
resolver
uniprot
Q5W0K6
resolver
uniprot
Q6P9E2
resolver
uniprot
Q8WX37
resolver
uniprot_entry
A8K9D8_HUMAN
resolver
uniprot_entry
Q6P9E2_HUMAN
resolver
uniprot_entry
RECK_HUMAN
resolver
uniprot_sec
B2RNS1
resolver
uniprot_sec
Q5W0K6
resolver
uniprot_sec
Q8WX37
resolver
amino_acid_sequence
MATVRASLRGALLLLLAVAGVAEVAGGLAPGSAGALCCNHSKDNQMCRDVCEQIFSSKSESRLKHLLQRAPDYCPETMVEIWNCMNSSLPGVFKKSDGWVGLGCCELAIALECRQACKQASSKNDISKVCRKEYENALFSCISRNEMGSVCCSYAGHHTNCREYCQAIFRTDSSPGPSQIKAVENYCASISPQLIHCVNNYTQSYPMRNPTDSLYCCDRAEDHACQNACKRILMSKKTEMEIVDGLIEGCKTQPLPQDPLWQCFLESSQSVHPGVTVHPPPSTGLDGAKLHCCSKANTSTCRELCTKLYSMSWGNTQSWQEFDRFCEYNPVEVSMLTCLADVREPCQLGCRNLTYCTNFNNRPTELFRSCNAQSDQGAMNDMKLWEKGSIKMPFINIPVLDIKKCQPEMWKAIACSLQIKPCHSKSRGSIICKSDCVEILKKCGDQNKFPEDHTAESICELLSPTDDLKNCIPLDTYLRPSTLGNIVEEVTHPCNPNPCPANELCEVNRKGCPSGDPCLPYFCVQGCKLGEASDFIVRQGTLIQVPSSAGEVGCYKICSCGQSGLLENCMEMHCIDLQKSCIVGGKRKSHGTSFSIDCNVCSCFAGNLVCSTRLCLSEHSSEDDRRTFTGLPCNCADQFVPVCGQNGRTYPSACIARCVGLQDHQFEFGSCMSKDPCNPNPCQKNQRCIPKPQVCLTTFDKFGCSQYECVPRQLACDQVQDPVCDTDHMEHNNLCTLYQRGKSLSYKGPCQPFCRATEPVCGHNGETYSSVCAAYSDRVAVDYYGDCQAVGVLSEHSSVAECASVKCPSLLAAGCKPIIPPGACCPLCAGMLRVLFDKEKLDTIAKVTNKKPITVLEILQKIRMHVSVPQCDVFGYFSIESEIVILIIPVDHYPKALQIEACNKEAEKIESLINSDSPTLASHVPLSALIISQVQVSSSVPSAGVRARPSCHSLLLPLSLGLALHLLWTYN
uniprot
proteins
function
FUNCTION: Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7 (PubMed:30026314). ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). Also acts as a serine protease inhibitor: negatively regulates matrix metalloproteinase-9 (MMP9) by suppressing MMP9 secretion and by direct inhibition of its enzymatic activity (PubMed:18194466, PubMed:9789069). Also inhibits metalloproteinase activity of MMP2, MMP14 (MT1-MMP) and ADAM10 (PubMed:9789069, PubMed:33731436). {ECO:0000250|UniProtKB:Q9Z0J1, ECO:0000269|PubMed:18194466, ECO:0000269|PubMed:28289266, ECO:0000269|PubMed:30026314, ECO:0000269|PubMed:33731436, ECO:0000269|PubMed:9789069}.
uniprot
proteins
mass_dalton
106457
uniprot
proteins
mutagenesis
MUTAGEN 225..272; /note="Missing: Abolished interaction with WNT7A."; /evidence="ECO:0000269|PubMed:30026314
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:9789069}.; PTM: GPI-anchored. Cleavage of the GPI-anchor by GDPD5 and release of RECK from the plasma membrane negatively regulates its activity toward ADAM10. {ECO:0000269|PubMed:33731436}.
uniprot
proteins
protein_family
RECK family
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18194466
uniprot
proteins
pubmed
28289266
uniprot
proteins
pubmed
30026314
uniprot
proteins
pubmed
33731436
uniprot
proteins
pubmed
9789069
uniprot
proteins
sequence_length
971
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:30026314, ECO:0000269|PubMed:33731436, ECO:0000269|PubMed:9789069}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:33731436, ECO:0000269|PubMed:9789069}.
uniprot
proteins