Kirrel1
entrez
310695
canonical
uniprot
Q6X936
canonical
ensembl
ENSRNOG00000016408
resolver
ensp
ENSRNOP00000033900
resolver
ensp
ENSRNOP00000100429
resolver
enst
ENSRNOT00000134383
resolver
genesymbol
Kirrel1
resolver
genesymbol_syn
Kirrel
resolver
genesymbol_syn
Neph1
resolver
uniprot
A0ABK0LCA7
resolver
uniprot
F1M7V1
resolver
uniprot
Q80W67
resolver
uniprot_entry
A0ABK0LCA7_RAT
resolver
uniprot_entry
KIRR1_RAT
resolver
uniprot_sec
F1M7V1
resolver
uniprot_sec
Q80W67
resolver
amino_acid_sequence
MTLENRSTCLMTCQSSLLPKKPRFLSQKMWAPHLVVAYLIFVTLALALPGTQTRFSQEPADQTVVAGHRAVLPCVLLNYSGIVQWTKDGLALGMGQGLKAWPRYRVVGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDTRIDGGPVILLQAGTPYNLTCRAFNAKPAATIIWFRDGTQQEGAVTSTELLKDGKRETTISQLLIQPTDLDIGRVFTCRSMNEAIPNGKETSIELDVHHPPTVTLSIEPQTVLEGERVIFTCQATANPEILGYRWAKGGFLIEDAHESRYETNVDYSFFTEPVSCEVYNKVGSTNVSTLVNVHFAPRIVVYPKPTTTDIGSDVTLTCVWVGNPPLTLTWTKKDSNMVLSNSNQLLLKSVTQADAGTYTCRAIVPRIGVAEREVPLYVNGPPIISSEAVQFAVRGDGGKVECFIGSTPPPDRIAWAWKENFLEVGTLERYTVERTNSGSGVLSTLTINNVMEADFQTHYNCTAWNSFGPGTAIIQLEEREVLPVGIIAGATIGAGILLVFSFAALVFFLYRRRKGSRKDVTLRKLDIKVETVNREPLTMHSDREDDTTSISTATRVMKAIYSSFKDDVDLKQDLHCDTIETREEYEMKDPTNGYYNVRAHEDRPSSRAVLYADYRAPGPTRFDGRPSSRLSHSSGYAQLNTYSRAPASDYGTEPTPSGPSAPGGTDTTSQLSYENYEKFNSHPFPGAAGYPTYRLGYPQAPPSGLERTPYEAYDPIGKYATATRFSYTSQHSDYGQRFQQRMQTHV
uniprot
proteins
function
FUNCTION: Required for proper function of the glomerular filtration barrier. It is involved in the maintenance of a stable podocyte architecture with interdigitating foot processes connected by specialized cell-cell junctions, known as the slit diaphragm (By similarity). It is a signaling protein that needs the presence of TEC kinases to fully trans-activate the transcription factor AP-1 (By similarity). {ECO:0000250|UniProtKB:Q96J84}.
uniprot
proteins
mass_dalton
87241
uniprot
proteins
post_translational_modification
PTM: Phosphorylation probably regulates the interaction with NPHS2 (By similarity). Phosphorylated at Tyr-637 and Tyr-638 by FYN, leading to GRB2 binding. {ECO:0000250, ECO:0000269|PubMed:18258597}.; PTM: N-glycosylated. {ECO:0000250}.
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
12865409
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
18258597
uniprot
proteins
sequence_length
789
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. Note=Predominantly located at podocyte slit diaphragm. {ECO:0000269|PubMed:12865409}.
uniprot
proteins
transmembrane_region
TRANSMEM 532..552; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins