CIPC
entrez
85457
canonical
uniprot
Q9C0C6
canonical
ensembl
ENSG00000198894
resolver
ensp
ENSP00000355319
resolver
ensp
ENSP00000550081
resolver
ensp
ENSP00000550082
resolver
ensp
ENSP00000550083
resolver
ensp
ENSP00000550084
resolver
ensp
ENSP00000550085
resolver
ensp
ENSP00000550086
resolver
ensp
ENSP00000550087
resolver
ensp
ENSP00000550088
resolver
ensp
ENSP00000600445
resolver
ensp
ENSP00000600446
resolver
ensp
ENSP00000641361
resolver
ensp
ENSP00000641363
resolver
ensp
ENSP00000641364
resolver
enst
ENST00000361786
resolver
enst
ENST00000880022
resolver
enst
ENST00000880023
resolver
enst
ENST00000880024
resolver
enst
ENST00000880025
resolver
enst
ENST00000880026
resolver
enst
ENST00000880027
resolver
enst
ENST00000880028
resolver
enst
ENST00000880029
resolver
enst
ENST00000930386
resolver
enst
ENST00000930387
resolver
enst
ENST00000971302
resolver
enst
ENST00000971304
resolver
enst
ENST00000971305
resolver
genesymbol
CIPC
resolver
genesymbol_syn
KIAA1737
resolver
hgnc
HGNC:20365
resolver
uniprot
B2RCI1
resolver
uniprot
Q8N389
resolver
uniprot
Q8NDZ1
resolver
uniprot_entry
CIPC_HUMAN
resolver
uniprot_sec
B2RCI1
resolver
uniprot_sec
Q8N389
resolver
uniprot_sec
Q8NDZ1
resolver
amino_acid_sequence
MERKNPSRESPRRLSAKVGKGTEMKKVARQLGMAAAESDKDSGFSDGSSECLSSAEQMESEDMLSALGWSREDRPRQNSKTAKNAFPTLSPMVVMKNVLVKQGSSSSQLQSWTVQPSFEVISAQPQLLFLHPPVPSPVSPCHTGEKKSDSRNYLPILNSYTKIAPHPGKRGLSLGPEEKGTSGVQKKICTERLGPSLSSSEPTKAGAVPSSPSTPAPPSAKLAEDSALQGVPSLVAGGSPQTLQPVSSSHVAKAPSLTFASPASPVCASDSTLHGLESNSPLSPLSANYSSPLWAAEHLCRSPDIFSEQRQSKHRRFQNTLVVLHKSGLLEITLKTKELIRQNQATQVELDQLKEQTQLFIEATKSRAPQAWAKLQASLTPGSSNTGSDLEAFSDHPAI
uniprot
proteins
function
FUNCTION: Transcriptional repressor which may act as a negative-feedback regulator of CLOCK-BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate BMAL1-dependent phosphorylation of CLOCK. However, the physiological relevance of these observations is unsure, since experiments in an animal model showed that CIPC is not critially required for basic circadian clock. {ECO:0000250|UniProtKB:Q8R0W1}.
uniprot
proteins
mass_dalton
42692
uniprot
proteins
mutagenesis
MUTAGEN 186; /note="K->A: Loss of predominant localization in the nucleus; when associated with A-187. No effect on CAD- ANDHSPA5-binding; when associated with A-187."; /evidence="ECO:0000269|PubMed:26657846"; MUTAGEN 187; /note="K->A: Loss of predominant localization in the nucleus; when associated with A-186. No effect on CAD- ANDHSPA5-binding; when associated with A-186."; /evidence="ECO:0000269|PubMed:26657846
uniprot
proteins
pubmed
11214970
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26657846
uniprot
proteins
sequence_length
399
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:26657846}. Cytoplasm, cytosol {ECO:0000269|PubMed:26657846}. Note=Predominantly localizes to the nucleus, where it co-localizes with CLOCK. At the G1/S boundary, partially translocated to the cytosol. {ECO:0000250|UniProtKB:Q8R0W1, ECO:0000269|PubMed:26657846}.
uniprot
proteins