Rps6
entrez
20104
canonical
uniprot
P62754
canonical
ensembl
ENSMUSG00000028495
resolver
ensp
ENSMUSP00000099878
resolver
enst
ENSMUST00000102814
resolver
genesymbol
Rps6
resolver
uniprot
P08227
resolver
uniprot
P10660
resolver
uniprot
Q5BLK1
resolver
uniprot_entry
Q5BLK1_MOUSE
resolver
uniprot_entry
RS6_MOUSE
resolver
uniprot_sec
P08227
resolver
uniprot_sec
P10660
resolver
amino_acid_sequence
MKLNISFPATGCQKLIEVDDERKLRTFYEKRMATEVAADALGEEWKGYVVRISGGNDKQGFPMKQGVLTHGRVRLLLSKGHSCYRPRRTGERKRKSVRGCIVDANLSVLNLVIVKKGEKDIPGLTDTTVPRRLGPKRASRIRKLFNLSKEDDVRQYVVRKPLNKEGKKPRTKAPKIQRLVTPRVLQHKRRRIALKKQRTKKNKEEAAEYAKLLAKRMKEAKEKRQEQIAKRRRLSSLRASTSKSESSQK
uniprot
proteins
function
FUNCTION: Component of the 40S small ribosomal subunit. Plays an important role in controlling cell growth and proliferation through the selective translation of particular classes of mRNA (PubMed:36517592). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (By similarity). {ECO:0000250|UniProtKB:P62753, ECO:0000269|PubMed:36517592}.
uniprot
proteins
mass_dalton
28681
uniprot
proteins
post_translational_modification
PTM: Ribosomal protein S6 is the major substrate of protein kinases in eukaryote ribosomes. The phosphorylation is stimulated by growth factors, tumor promoting agents, and mitogens. It is dephosphorylated at growth arrest. Phosphorylated at Ser-235 and Ser-236 by RPS6KA1 and RPS6KA3; phosphorylation at these sites facilitates the assembly of the pre-initiation complex. {ECO:0000269|PubMed:1939282, ECO:0000269|PubMed:8440735}.; PTM: Specifically hydroxylated (with R stereochemistry) at C-3 of Arg-137 by KDM8. {ECO:0000250|UniProtKB:P62753}.; PTM: Mono-ADP-ribosylation at Glu-35 by PARP16 inhibits polysome assembly and mRNA loading, thereby inhibiting protein translation. {ECO:0000250|UniProtKB:P62753}.
uniprot
proteins
protein_family
Eukaryotic ribosomal protein eS6 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1939282
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
3601662
uniprot
proteins
pubmed
36517592
uniprot
proteins
pubmed
8440735
uniprot
proteins
pubmed
8917105
uniprot
proteins
sequence_length
249
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:36517592}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P62753}.
uniprot
proteins