TMBIM6
entrez
7009
canonical
uniprot
P55061
canonical
ensembl
ENSG00000139644
resolver
ensp
ENSP00000267115
resolver
ensp
ENSP00000389277
resolver
ensp
ENSP00000446734
resolver
ensp
ENSP00000448036
resolver
ensp
ENSP00000450158
resolver
ensp
ENSP00000530476
resolver
ensp
ENSP00000530485
resolver
ensp
ENSP00000530492
resolver
ensp
ENSP00000594274
resolver
genesymbol
TMBIM6
resolver
genesymbol_syn
BI1
resolver
genesymbol_syn
TEGT
resolver
hgnc
HGNC:11723
resolver
uniprot
B2R5M4
resolver
uniprot
F8W034
resolver
uniprot
O14938
resolver
uniprot
Q643A7
resolver
uniprot
Q96J50
resolver
uniprot_entry
BI1_HUMAN
resolver
uniprot_sec
B2R5M4
resolver
uniprot_sec
F8W034
resolver
uniprot_sec
O14938
resolver
uniprot_sec
Q643A7
resolver
uniprot_sec
Q96J50
resolver
amino_acid_sequence
MNIFDRKINFDALLKFSHITPSTQQHLKKVYASFALCMFVAAAGAYVHMVTHFIQAGLLSALGSLILMIWLMATPHSHETEQKRLGLLAGFAFLTGVGLGPALEFCIAVNPSILPTAFMGTAMIFTCFTLSALYARRRSYLFLGGILMSALSLLLLSSLGNVFFGSIWLFQANLYVGLVVMCGFVLFDTQLIIEKAEHGDQDYIWHCIDLFLDFITVFRKLMMILAMNEKDKKKEKK
uniprot
proteins
function
FUNCTION: Endoplasmic reticulum (ER)-resident protein that confers cellular protection as an anti-apoptotic protein by limiting multiple stress-inducing pathways surrounding the endoplasmic reticulum and mitochondria (PubMed:21075086, PubMed:21068390). Inhibits the activities of the key sensor for the endoplasmic reticulum unfolded protein response IRE1alpha/ERN1 both directly and by blocking BAX/BAK binding (PubMed:19328063). Modulates ER calcium homeostasis by acting as a calcium-leak channel (PubMed:22128171). Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation (By similarity). {ECO:0000250|UniProtKB:Q9D2C7, ECO:0000269|PubMed:19328063, ECO:0000269|PubMed:21068390, ECO:0000269|PubMed:21075086, ECO:0000269|PubMed:22128171}.
uniprot
proteins
mass_dalton
26538
uniprot
proteins
mutagenesis
MUTAGEN 209; /note="D->A: Abolishes calcium flux properties."; /evidence="ECO:0000269|PubMed:22128171"; MUTAGEN 213; /note="D->A: Abolishes calcium flux properties."; /evidence="ECO:0000269|PubMed:22128171
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by BFAR, leading to proteasomal degradation. {ECO:0000269|PubMed:21068390}.
uniprot
proteins
protein_family
BI1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
19328063
uniprot
proteins
pubmed
21068390
uniprot
proteins
pubmed
21075086
uniprot
proteins
pubmed
22128171
uniprot
proteins
pubmed
22418439
uniprot
proteins
pubmed
8530040
uniprot
proteins
pubmed
9660918
uniprot
proteins
sequence_length
237
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:21068390, ECO:0000269|PubMed:21075086, ECO:0000269|PubMed:22128171}; Multi-pass membrane protein {ECO:0000269|PubMed:21075086, ECO:0000269|PubMed:22128171}.
uniprot
proteins
transmembrane_region
TRANSMEM 30..50; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 53..73; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 87..107; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 113..133; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 140..160; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 167..187; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins