Alad
entrez
25374
canonical
uniprot
P06214
canonical
ensembl
ENSRNOG00000015206
resolver
ensembl
ENSRNOG00055018142
resolver
ensembl
ENSRNOG00060010276
resolver
ensembl
ENSRNOG00065016023
resolver
ensp
ENSRNOP00000020625
resolver
ensp
ENSRNOP00000068140
resolver
ensp
ENSRNOP00055024759
resolver
ensp
ENSRNOP00060013521
resolver
ensp
ENSRNOP00065020925
resolver
enst
ENSRNOT00000020625
resolver
enst
ENSRNOT00000075916
resolver
enst
ENSRNOT00055030768
resolver
enst
ENSRNOT00060017404
resolver
enst
ENSRNOT00065026678
resolver
genesymbol
Alad
resolver
uniprot
A0A8L2R0C7
resolver
uniprot_entry
A0A8L2R0C7_RAT
resolver
uniprot_entry
HEM2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Can alternate between a fully active homooctamer and a low-activity homohexamer. A bound magnesium ion may promote the assembly of the fully active homooctamer. The magnesium-binding site is absent in the low-activity homohexamer. Inhibited by compounds that favor the hexameric state. Inhibited by divalent lead ions. The lead ions partially displace the zinc cofactor. {ECO:0000250|UniProtKB:P13716}.
uniprot
proteins
amino_acid_sequence
MHHQSVLHSGYFHPLLRAWQTTPSTVSATNLIYPIFVTDVPDDVQPIASLPGVARYGVNQLEEMLRPLVEAGLRCVLIFGVPSRVPKDEQGSAADSEDSPTIEAVRLLRKTFPTLLVACDVCLCPYTSHGHCGLLSENGAFLAEESRQRLAEVALAYAKAGCQVVAPSDMMDGRVEAIKAALLKHGLGNRVSVMSYSAKFASCFYGPFRDAAQSSPAFGDRRCYQLPPGARGLALRAVARDIQEGADILMVKPGLPYLDMVQEVKDKHPELPLAVYQVSGEFAMLWHGAKAGAFDLRTAVLESMTAFRRAGADIIITYFAPQLLKWLKEE
uniprot
proteins
ec_number
4.2.1.24
uniprot
proteins
function
FUNCTION: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen. {ECO:0000250|UniProtKB:P13716}.
uniprot
proteins
mass_dalton
36032
uniprot
proteins
pathway_participation
PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4. {ECO:0000250|UniProtKB:P13716}.
uniprot
proteins
protein_family
ALAD family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
3502704
uniprot
proteins
pubmed
3808948
uniprot
proteins
sequence_length
330
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P10518}.
uniprot
proteins