Avp
entrez
11998
canonical
uniprot
P35455
canonical
ensembl
ENSMUSG00000037727
resolver
ensp
ENSMUSP00000035551
resolver
enst
ENSMUST00000046001
resolver
genesymbol
Avp
resolver
uniprot
Q3UUQ5
resolver
uniprot_entry
NEU2_MOUSE
resolver
uniprot_entry
Q3UUQ5_MOUSE
resolver
amino_acid_sequence
MLARMLNTTLSACFLSLLAFSSACYFQNCPRGGKRAISDMELRQCLPCGPGGKGRCFGPSICCADELGCFVGTAEALRCQEENYLPSPCQSGQKPCGSGGRCAAVGICCSDESCVAEPECHDGFFRLTRAREPSNATQLDGPARALLLRLVQLAGTRESVDSAKPRVY
uniprot
proteins
function
FUNCTION: Precursor of Arg-vasopressin, an antidiuretic hormone, and neurophysin 2, its carrier protein. {ECO:0000250|UniProtKB:P01186}.; FUNCTION: [Arg-vasopressin]: Has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels. Acts by binding to vasopressin receptors (V1bR/AVPR1B, V1aR/AVPR1A, and V2R/AVPR2). {ECO:0000250|UniProtKB:P01185}.; FUNCTION: [Neurophysin 2]: Carrier protein that binds to and transports Arg-vasopressin from the hypothalamus to the posterior pituitary gland, protecting it from degradation and facilitating its release. {ECO:0000250|UniProtKB:P01186}.
uniprot
proteins
mass_dalton
17900
uniprot
proteins
mutagenesis
MUTAGEN 102..168; /note="Missing: Homozygous knockin mice display lethality. Heterozygous mice show diabetes insipidus, characterized by polyuria and polydipsia by 2 months of age; these features progressively worsen with age."; /evidence="ECO:0000269|PubMed:14660745
uniprot
proteins
post_translational_modification
PTM: Synthesized as a large inactive precursor protein, which is cleaved into Arg-vasopressin and neurophysin 2 by endopeptidases, such as neuroendocrine convertases PCSK1 and PCSK2. Arg-vasopressin is then amidated at the C-terminus, completing its activation. {ECO:0000250|UniProtKB:P01186}.; PTM: [Arg-vasopressin]: Amidated at the C-terminus by alpha-amidating monooxygenase (PAM), completing its activation. {ECO:0000250|UniProtKB:P01186}.
uniprot
proteins
protein_family
Vasopressin/oxytocin family
uniprot
proteins
pubmed
14660745
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2176709
uniprot
proteins
sequence_length
168
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:P01186}. Note=The precursor protein is packaged into neurosecretory granules. {ECO:0000250|UniProtKB:P01186}.; SUBCELLULAR LOCATION: [Arg-vasopressin]: Secreted {ECO:0000250|UniProtKB:P01186}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:P01186}. Note=Following processing, Arg-vasopressin and neurophysin 2 are transported to the posterior pituitary and stored in neurosecretory granules at the nerve termini until secreted. {ECO:0000250|UniProtKB:P01186}.; SUBCELLULAR LOCATION: [Neurophysin 2]: Secreted {ECO:0000250|UniProtKB:P01186}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:P01186}. Note=Following processing, Arg-vasopressin and neurophysin 2 are transported to the posterior pituitary and stored in neurosecretory granules at the nerve termini until secreted. {ECO:0000250|UniProtKB:P01186}.
uniprot
proteins