MTMR3
entrez
8897
canonical
uniprot
Q13615
canonical
ensembl
ENSG00000100330
resolver
ensp
ENSP00000307271
resolver
ensp
ENSP00000331649
resolver
ensp
ENSP00000384651
resolver
genesymbol
MTMR3
resolver
genesymbol_syn
KIAA0371
resolver
genesymbol_syn
ZFYVE10
resolver
hgnc
HGNC:7451
resolver
uniprot
A5PL26
resolver
uniprot
A7MD32
resolver
uniprot
Q9NYN5
resolver
uniprot
Q9NYN6
resolver
uniprot
Q9UDX6
resolver
uniprot
Q9UEG3
resolver
uniprot_entry
MTMR3_HUMAN
resolver
uniprot_sec
A5PL26
resolver
uniprot_sec
A7MD32
resolver
uniprot_sec
Q9NYN5
resolver
uniprot_sec
Q9NYN6
resolver
uniprot_sec
Q9UDX6
resolver
uniprot_sec
Q9UEG3
resolver
amino_acid_sequence
MDEETRHSLECIQANQIFPRKQLIREDENLQVPFLELHGESTEFVGRAEDAIIALSNYRLHIKFKESLVNVPLQLIESVECRDIFQLHLTCKDCKVIRCQFSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAYHAWCMEVYASEKEQHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRNTSRDFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLPCPSPTTPVDDSCAPYPAPGTSPDDPPLSRLPKTRSYDNLTTACDNTVPLASRRCSDPSLNEKWQEHRRSLELSSLAGPGEDPLSADSLGKPTRVPGGAELSVAAGVAEGQMENILQEATKEESGVEEPAHRAGIEIQEGKEDPLLEKESRRKTPEASAIGLHQDPELGDAALRSHLDMSWPLFSQGISEQQSGLSVLLSSLQVPPRGEDSLEVPVEQFRIEEIAEGREEAVLPIPVDAKVGYGTSQSCSLLPSQVPFETRGPNVDSSTDMLVEDKVKSVSGPQGHHRSCLVNSGKDRLPQTMEPSPSETSLVERPQVGSVVHRTSLGSTLSLTRSPCALPLAECKEGLVCNGAPETENRASEQPPGLSTLQMYPTPNGHCANGEAGRSKDSLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGRPSATSSPDQPSRSHLDDDGMSVYTDTIQQRLRQIESGHQQEVETLKKQVQELKSRLESQYLTSSLHFNGDFGDEVTSIPDSESNLDQNCLSRCSTEIFSEASWEQVDKQDTEMTRWLPDHLAAHCYACDSAFWLASRKHHCRNCGNVFCSSCCNQKVPVPSQQLFEPSRVCKSCYSSLHPTSSSIDLELDKPIAATSN
uniprot
proteins
ec_number
3.1.3.95
uniprot
proteins
function
FUNCTION: Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate (PubMed:10733931, PubMed:11302699, PubMed:11676921, PubMed:12646134). Decreases the levels of phosphatidylinositol 3-phosphate, a phospholipid found in cell membranes where it acts as key regulator of both cell signaling and intracellular membrane traffic (PubMed:11302699, PubMed:11676921, PubMed:12646134). Could also have a molecular sequestering/adapter activity and regulate biological processes independently of its phosphatase activity. It includes the regulation of midbody abscission during mitotic cytokinesis (PubMed:25659891). {ECO:0000269|PubMed:10733931, ECO:0000269|PubMed:11302699, ECO:0000269|PubMed:11676921, ECO:0000269|PubMed:12646134, ECO:0000269|PubMed:25659891}.
uniprot
proteins
mass_dalton
133619
uniprot
proteins
mutagenesis
MUTAGEN 413; /note="C->S: Loss of lipid phosphatase activity. No effect on function in mitotic abscission."; /evidence="ECO:0000269|PubMed:11676921, ECO:0000269|PubMed:25659891, ECO:0000305|PubMed:32690950"; MUTAGEN 1174; /note="C->S: Loss of function in mitotic abscission. Decreased interaction with PLK1."; /evidence="ECO:0000269|PubMed:25659891
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CDK1 during mitosis. {ECO:0000269|PubMed:25659891}.
uniprot
proteins
protein_family
Non-receptor class myotubularin subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
10733931
uniprot
proteins
pubmed
11302699
uniprot
proteins
pubmed
11676921
uniprot
proteins
pubmed
12646134
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25659891
uniprot
proteins
pubmed
32690950
uniprot
proteins
pubmed
32929276
uniprot
proteins
pubmed
8640223
uniprot
proteins
pubmed
9205841
uniprot
proteins
pubmed
9736772
uniprot
proteins
sequence_length
1198
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:10733931, ECO:0000269|PubMed:11676921}. Membrane {ECO:0000269|PubMed:10733931, ECO:0000269|PubMed:11676921}; Peripheral membrane protein {ECO:0000269|PubMed:10733931, ECO:0000269|PubMed:11676921}.
uniprot
proteins