Tspan1
entrez
298436
canonical
uniprot
Q6AYR9
canonical
ensembl
ENSRNOG00000023320
resolver
ensembl
ENSRNOG00055013073
resolver
ensembl
ENSRNOG00060028016
resolver
ensembl
ENSRNOG00065016169
resolver
ensp
ENSRNOP00000018766
resolver
ensp
ENSRNOP00055018155
resolver
ensp
ENSRNOP00060040595
resolver
ensp
ENSRNOP00065021165
resolver
enst
ENSRNOT00000018766
resolver
enst
ENSRNOT00055022379
resolver
enst
ENSRNOT00060048682
resolver
enst
ENSRNOT00065026923
resolver
genesymbol
Tspan1
resolver
uniprot_entry
TSN1_RAT
resolver
amino_acid_sequence
MQCFKFIKVMMILFNLLIFLCGAALLAVGIWVSVDGTSFLKAFGSLSSSAMQFVNVGYFLIAAGAVLFILGFLGCYGAHSENKCVLMMFFSILLIIFIAEIAGAVVALVYTTMAEQFLTFLVVPAIEKDYGYQTEFTQVWNSTMEGLHCCGFNNYTDFNSSRFVKENKVFPPFCCANNTDSHTVEPCTEDKAKSMNVQGCFKQILQKIRTNAVTVGGVAVGVAALELAAMVVSMYLYCNLK
uniprot
proteins
function
FUNCTION: Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking (By similarity). Regulates neuronal differentiation in response to NGF by facilitating NGF-mediated activation of NTRK1/TRKA receptor tyrosine kinase and subsequent downstream signaling pathways (PubMed:31440771). Plays a role in the inhibition of TNFalpha-induced apoptosis. Mechanistically, inhibits the NF-kappa-B signaling pathway by blocking phosphorylation of CHUK. Also promotes the stability of the thiamine transporter 1/SLC19A2 in intestinal epithelial cells leading to an increase of thiamine uptake process (By similarity). {ECO:0000250|UniProtKB:O60635, ECO:0000269|PubMed:31440771}.
uniprot
proteins
mass_dalton
26453
uniprot
proteins
protein_family
Tetraspanin (TM4SF) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
31440771
uniprot
proteins
sequence_length
241
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:31440771}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 53..73; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 89..109; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 212..232; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins