HTR7
entrez
3363
canonical
uniprot
P34969
canonical
ensembl
ENSG00000148680
resolver
ensp
ENSP00000277874
resolver
ensp
ENSP00000337949
resolver
ensp
ENSP00000360784
resolver
genesymbol
HTR7
resolver
hgnc
HGNC:5302
resolver
uniprot
B5BUP6
resolver
uniprot
P78336
resolver
uniprot
P78372
resolver
uniprot
P78516
resolver
uniprot
Q5VX01
resolver
uniprot
Q5VX02
resolver
uniprot
Q5VX03
resolver
uniprot_entry
5HT7R_HUMAN
resolver
uniprot_sec
B5BUP6
resolver
uniprot_sec
P78336
resolver
uniprot_sec
P78372
resolver
uniprot_sec
P78516
resolver
uniprot_sec
Q5VX01
resolver
uniprot_sec
Q5VX02
resolver
uniprot_sec
Q5VX03
resolver
amino_acid_sequence
MMDVNSSGRPDLYGHLRSFLLPEVGRGLPDLSPDGGADPVAGSWAPHLLSEVTASPAPTWDAPPDNASGCGEQINYGRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADLSVAVAVMPFVSVTDLIGGKWIFGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGITRPLTYPVRQNGKCMAKMILSVWLLSASITLPPLFGWAQNVNDDKVCLISQDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKFPGFPRVEPDSVIALNGIVKLQKEVEECANLSRLLKHERKNISIFKREQKAATTLGIIVGAFTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTYRSLLQCQYRNINRKLSAAGMHEALKLAERPERPEFVLRACTRRVLLRPEKRPPVSVWVLQSPDHHNWLADKMLTTVEKKVMIHD
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone and a mitogen (PubMed:35714614, PubMed:8226867). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:35714614, PubMed:8226867). HTR7 is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (PubMed:35714614). {ECO:0000269|PubMed:35714614, ECO:0000269|PubMed:8226867}.
uniprot
proteins
mass_dalton
53555
uniprot
proteins
mutagenesis
MUTAGEN 162; /note="D->A: Abolished G protein-coupled receptor activity in response to serotonin."; /evidence="ECO:0000269|PubMed:35714614"; MUTAGEN 166; /note="C->A: Decreased G protein-coupled receptor activity in response to serotonin."; /evidence="ECO:0000269|PubMed:35714614"; MUTAGEN 167; /note="T->A: Decreased G protein-coupled receptor activity in response to serotonin."; /evidence="ECO:0000269|PubMed:35714614"; MUTAGEN 233; /note="I->A: Decreased G protein-coupled receptor activity in response to serotonin."; /evidence="ECO:0000269|PubMed:35714614"; MUTAGEN 240; /note="T->A: Decreased G protein-coupled receptor activity in response to serotonin."; /evidence="ECO:0000269|PubMed:35714614"; MUTAGEN 243; /note="S->A: Decreased G protein-coupled receptor activity in response to serotonin."; /evidence="ECO:0000269|PubMed:35714614"; MUTAGEN 340; /note="W->A: Decreased G protein-coupled receptor activity in response to serotonin."; /evidence="ECO:0000269|PubMed:35714614"; MUTAGEN 343; /note="F->A: Decreased G protein-coupled receptor activity in response to serotonin."; /evidence="ECO:0000269|PubMed:35714614"; MUTAGEN 344; /note="F->A: Decreased G protein-coupled receptor activity in response to serotonin."; /evidence="ECO:0000269|PubMed:35714614"; MUTAGEN 374; /note="Y->A: Decreased G protein-coupled receptor activity in response to serotonin."; /evidence="ECO:0000269|PubMed:35714614
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19054851
uniprot
proteins
pubmed
22448645
uniprot
proteins
pubmed
35714614
uniprot
proteins
pubmed
8226867
uniprot
proteins
pubmed
9084407
uniprot
proteins
pubmed
9154233
uniprot
proteins
sequence_length
479
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22448645}; Multi-pass membrane protein {ECO:0000269|PubMed:35714614}.
uniprot
proteins
transmembrane_region
TRANSMEM 84..108; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:35714614, ECO:0007744|PDB:7XTC"; TRANSMEM 119..140; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:35714614, ECO:0007744|PDB:7XTC"; TRANSMEM 153..178; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:35714614, ECO:0007744|PDB:7XTC"; TRANSMEM 199..219; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:35714614, ECO:0007744|PDB:7XTC"; TRANSMEM 238..260; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:35714614, ECO:0007744|PDB:7XTC"; TRANSMEM 327..352; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:35714614, ECO:0007744|PDB:7XTC"; TRANSMEM 364..387; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:35714614, ECO:0007744|PDB:7XTC
uniprot
proteins