B4galt4
entrez
56375
canonical
uniprot
Q9JJ04
canonical
ensembl
ENSMUSG00000022793
resolver
ensp
ENSMUSP00000023482
resolver
ensp
ENSMUSP00000110360
resolver
ensp
ENSMUSP00000220381
resolver
ensp
ENSMUSP00000220383
resolver
ensp
ENSMUSP00000220385
resolver
enst
ENSMUST00000023482
resolver
enst
ENSMUST00000114712
resolver
genesymbol
B4galt4
resolver
uniprot
Q8BR54
resolver
uniprot
Q9QY12
resolver
uniprot_entry
B4GT4_MOUSE
resolver
uniprot_sec
Q8BR54
resolver
uniprot_sec
Q9QY12
resolver
amino_acid_sequence
MGCNPPYHLSYRLRLLLLFTLCLTVVGWATSNYFVGAIQVIPKAKDFMASFHKVIHLGNEETLGHDGATKKPELANCPSVSPNLRGQSKLVFKPDLTLEEIEAENPKVSRGRYHPEECKALQRVAILIPHRNREKHLIYLLEHLHPFLQRQQLDYGIYIIHQTGSKKFNRAKLLNVGYLEALKEENWDCFVFHDVDLVPENDFNLYTCGDQPKHLVVGRNSTGYRLRYSKYFGGVTALSREQFLKVNGFSNNYWGWGGEDDDLRLRVELHKMKISRPKPDVGKYTMIFHTRDKGNEVNMGRMKLLQQMSRVWKTDGLSSCSYRLLSVEHNPLYANITVDFWTAA
uniprot
proteins
ec_number
2.4.1.-
uniprot
proteins
ec_number
2.4.1.275
uniprot
proteins
ec_number
2.4.1.90
uniprot
proteins
function
FUNCTION: Galactose (Gal) transferase involved in the synthesis of terminal N-acetyllactosamine (LacNac) unit present on glycan chains of glycoproteins and glycosphingolipids. Catalyzes the transfer of Gal residue via a beta1->4 linkage from UDP-Gal to the non-reducing terminal N-acetyl glucosamine 6-O-sulfate (6-O-sulfoGlcNAc) in the linearly growing chain of both N- and O-linked keratan sulfate proteoglycans. Cooperates with B3GNT7 N-acetyl glucosamine transferase and CHST6 and CHST1 sulfotransferases to construct and elongate mono- and disulfated disaccharide units [->3Galbeta1->4(6-sulfoGlcNAcbeta)1->] and [->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer. Transfers Gal residue via a beta1->4 linkage to terminal 6-O-sulfoGlcNAc within the LacNac unit of core 2 O-glycans forming 6-sulfo-sialyl-Lewis X (sLex). May contribute to the generation of sLex epitope on mucin-type glycoproteins that serve as ligands for SELL/L-selectin, a major regulator of leukocyte migration. In the biosynthesis pathway of neolacto-series glycosphingolipids, transfers Gal residue via a beta1->4 linkage to terminal GlcNAc of a lactotriaosylceramide (Lc3Cer) acceptor to form a neolactotetraosylceramide. Efficiently galactosylates both non-sulfated and 6-O-sulfated terminal GlcNAc moities on G0 complex-type N-glycans. {ECO:0000250|UniProtKB:O60513}.
uniprot
proteins
mass_dalton
39700
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:O60513}.; PATHWAY: Glycolipid biosynthesis. {ECO:0000250|UniProtKB:O60513}.
uniprot
proteins
protein_family
Glycosyltransferase 7 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
9597550
uniprot
proteins
sequence_length
344
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:O60513}; Single-pass type II membrane protein {ECO:0000255}. Secreted {ECO:0000250|UniProtKB:O60513}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..38; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins