Secisbp2
entrez
79049
canonical
uniprot
Q9QX72
canonical
ensembl
ENSRNOG00000013773
resolver
ensp
ENSRNOP00000039532
resolver
enst
ENSRNOT00000041371
resolver
genesymbol
Secisbp2
resolver
genesymbol_syn
Sbp2
resolver
uniprot
F1LPQ8
resolver
uniprot_entry
F1LPQ8_RAT
resolver
uniprot_entry
SEBP2_RAT
resolver
amino_acid_sequence
MASERPREPEGEDSIKLSADVKPFVPKFAGLNVAWSESSEACVFPGCAATYYPFVQESPAAEQKMYPEDMAFGAPAFPAQYVSSEIALHPFAYPTYALESTQSVCSVPTLQYDYSQAQCHPGFRPAKPRNEHACPPQEAKCVFKKKSSDERRAWEEQKSSNRRADGAVPCEARPARGSCHLKSDGYHKRPDRKSRILTKSASTSKPEFEFSRLDFPELQSPKNSNLPETQKQPRWGPLGPAASNMSLLGEAGKPVADMVEGKMVKTDHTDGAVTNNAATSSPSCTRELSWTPMGYIVRQTVSSDSAAATETVNSIINLKKTTSSADAKNVSVTSEALSSDPSFSREKRVHPGPKAKASQGSELEQNESSKKNKKKKEKSKSSYEVLPVQEPPRIEDAEEFPNLSVASERRHRGESPKLQSKQQAQNDFKTGGKKSQVPVQLDLGGMLAALEKQQHAPHAKPSSRPVVFSVGAVPVLSKDASSGERGRRSSQVKTPHNPLDSSAPLMKKGKQREIPKAKKPTSLKKIILKERQERMQQRLQESAVSPTVASDDSQDVESGVTNQIPSPDNPTGPEKTEEPMSSTPVVEGESEEPAGTEFQRDPEACQPAPDSATFPKIHSRRFRDYCSQMLSKEVDACVTGLLKELVRFQDRMYQKDPVKAKTKRRLVLGLREVLKHLKLRKLKCIIISPNCEKTQSKGGLDDTLHTIIDCACEQNIPFVFALNRKALGRSLNKAVPVSIVGIFSYDGAQDQFHKMVELTMAARQAYKTMLETMRQEQAGEPGPQTPPSPPMQDPIQSTDEGTLASTGEEPHYIEIWRKHLEAYSQHALELEDSLEASTSQMMNLNL
uniprot
proteins
function
FUNCTION: mRNA-binding protein that binds to the SECIS (selenocysteine insertion sequence) element present in the 3'-UTR of mRNAs encoding selenoproteins and facilitates the incorporation of the rare amino acid selenocysteine (PubMed:10464275, PubMed:10637234). Insertion of selenocysteine at UGA codons is mediated by SECISBP2 and EEFSEC: SECISBP2 (1) specifically binds the SECIS sequence once the 80S ribosome encounters an in-frame UGA codon and (2) contacts the RPS27A/eS31 of the 40S ribosome before ribosome stalling (By similarity). (3) GTP-bound EEFSEC then delivers selenocysteinyl-tRNA(Sec) to the 80S ribosome and adopts a preaccommodated state conformation (By similarity). (4) After GTP hydrolysis, EEFSEC dissociates from the assembly, selenocysteinyl-tRNA(Sec) accommodates, and peptide bond synthesis and selenoprotein elongation occur (By similarity). {ECO:0000250|UniProtKB:Q96T21, ECO:0000269|PubMed:10464275, ECO:0000269|PubMed:10637234}.
uniprot
proteins
mass_dalton
93300
uniprot
proteins
pubmed
10464275
uniprot
proteins
pubmed
10637234
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
846
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:10637234}. Nucleus {ECO:0000305|PubMed:10637234}.
uniprot
proteins