TBC1D1
entrez
23216
canonical
uniprot
Q86TI0
canonical
ensembl
ENSG00000065882
resolver
ensp
ENSP00000261439
resolver
ensp
ENSP00000421641
resolver
ensp
ENSP00000423651
resolver
ensp
ENSP00000513987
resolver
ensp
ENSP00000529706
resolver
ensp
ENSP00000529707
resolver
ensp
ENSP00000529710
resolver
ensp
ENSP00000606300
resolver
ensp
ENSP00000631397
resolver
enst
ENST00000698857
resolver
genesymbol
TBC1D1
resolver
genesymbol_syn
KIAA1108
resolver
hgnc
HGNC:11578
resolver
uniprot
A0A8V8TNS9
resolver
uniprot
B7Z3D9
resolver
uniprot
B9A6J6
resolver
uniprot
E9PGH8
resolver
uniprot
Q6PJJ8
resolver
uniprot
Q8NC59
resolver
uniprot
Q96K82
resolver
uniprot
Q9UPP4
resolver
uniprot_entry
A0A8V8TNS9_HUMAN
resolver
uniprot_entry
B9A6J6_HUMAN
resolver
uniprot_entry
Q6PJJ8_HUMAN
resolver
uniprot_entry
Q8NC59_HUMAN
resolver
uniprot_entry
TBCD1_HUMAN
resolver
uniprot_sec
B7Z3D9
resolver
uniprot_sec
E9PGH8
resolver
uniprot_sec
Q96K82
resolver
uniprot_sec
Q9UPP4
resolver
amino_acid_sequence
MEPITFTARKHLLSNEVSVDFGLQLVGSLPVHSLTTMPMLPWVVAEVRRLSRQSTRKEPVTKQVRLCVSPSGLRCEPEPGRSQQWDPLIYSSIFECKPQRVHKLIHNSHDPSYFACLIKEDAVHRQSICYVFKADDQTKVPEIISSIRQAGKIARQEELHCPSEFDDTFSKKFEVLFCGRVTVAHKKAPPALIDECIEKFNHVSGSRGSESPRPNPPHAAPTGSQEPVRRPMRKSFSQPGLRSLAFRKELQDGGLRSSGFFSSFEESDIENHLISGHNIVQPTDIEENRTMLFTIGQSEVYLISPDTKKIALEKNFKEISFCSQGIRHVDHFGFICRESSGGGGFHFVCYVFQCTNEALVDEIMMTLKQAFTVAAVQQTAKAPAQLCEGCPLQSLHKLCERIEGMNSSKTKLELQKHLTTLTNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHIGEMKQTSQMAAENIGSELPPSATRFRLDMLKNKAKRSLTESLESILSRGNKARGLQEHSISVDLDSSLSSTLSNTSKEPSVCEKEALPISESSFKLLGSSEDLSSDSESHLPEEPAPLSPQQAFRRRANTLSHFPIECQEPPQPARGSPGVSQRKLMRYHSVSTETPHERKDFESKANHLGDSGGTPVKTRRHSWRQQIFLRVATPQKACDSSSRYEDYSELGELPPRSPLEPVCEDGPFGPPPEEKKRTSRELRELWQKAILQQILLLRMEKENQKLQASENDLLNKRLKLDYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFIKSTLPNLGLVQMEKTINQVFEMDIAKQLQAYEVEYHVLQEELIDSSPLSDNQRMDKLEKTNSSLRKQNLDLLEQLQVANGRIQSLEATIEKLLSSESKLKQAMLTLELERSALLQTVEELRRRSAEPSDREPECTQPEPTGD
uniprot
proteins
function
FUNCTION: May act as a GTPase-activating protein for Rab family protein(s). May play a role in the cell cycle and differentiation of various tissues. Involved in the trafficking and translocation of GLUT4-containing vesicles and insulin-stimulated glucose uptake into cells (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
133084
uniprot
proteins
mutagenesis
MUTAGEN 930; /note="M->A: Substantially reduced RabGAPGTPase hydrolysis activity."; /evidence="ECO:0000269|PubMed:21454505"; MUTAGEN 1019; /note="L->A: Substantially reduced RabGAPGTPase hydrolysis activity."; /evidence="ECO:0000269|PubMed:21454505
uniprot
proteins
post_translational_modification
PTM: Insulin-stimulated phosphorylation by AKT family kinases stimulates SLC2A4/GLUT4 translocation. {ECO:0000250}.
uniprot
proteins
pubmed
10470851
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16893906
uniprot
proteins
pubmed
18325908
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21454505
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24879834
uniprot
proteins
sequence_length
1168
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins