C1qc
entrez
362634
canonical
uniprot
P31722
canonical
genesymbol
C1qc
resolver
genesymbol_syn
C1qg
resolver
uniprot
Q5RJZ8
resolver
uniprot_entry
C1QC_RAT
resolver
uniprot_sec
Q5RJZ8
resolver
activity_regulation
ACTIVITY REGULATION: The C1Q subcomplex is inhibited by sulfated molecules, such as triterpenoid sulfates, heparan sulfate, or chondroitin sulfates. {ECO:0000250|UniProtKB:P02747}.
uniprot
proteins
amino_acid_sequence
MVVGTSCQPQHGLYLLLLLLALPLRSQANAGCYGIPGMPGLPGTPGKDGHDGLQGPKGEPGIPAIPGTQGPKGQKGEPGMPGHRGKNGPMGTSGSPGDPGPRGPPGEPGEEGRYKQKHQSVFTVTRQTAQYPAANGLVKFNSAITNPQGDYNTNTGKFTCKVPGLYYFVHHTSQTANLCVQLLLNNAKVTSFCDHMSNSKQVSSGGVLLRLQRGDEVWLAVNDYNGMVGTEGSDSVFSGFLLFPD
uniprot
proteins
function
FUNCTION: Core component of the complement C1 complex, a multiprotein complex that initiates the classical pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system. The classical complement pathway is initiated by the C1Q subcomplex of the C1 complex, which specifically binds IgG or IgM immunoglobulins complexed with antigens, forming antigen-antibody complexes on the surface of pathogens: C1QA, together with C1QB and C1QC, specifically recognizes and binds the Fc regions of IgG or IgM via its C1q domain. Immunoglobulin-binding activates the proenzyme C1R, which cleaves C1S, initiating the proteolytic cascade of the complement system. The C1Q subcomplex is activated by a hexamer of IgG complexed with antigens, while it is activated by a pentameric IgM. The C1Q subcomplex also recognizes and binds phosphatidylserine exposed on the surface of cells undergoing programmed cell death, possibly promoting activation of the complement system. {ECO:0000250|UniProtKB:P02747}.
uniprot
proteins
mass_dalton
25686
uniprot
proteins
post_translational_modification
PTM: O-linked glycans consist of Glc-Gal disaccharides bound to the oxygen atom of post-translationally added hydroxyl groups. {ECO:0000250|UniProtKB:P02747}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8464426
uniprot
proteins
sequence_length
245
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8464426}. Cell surface {ECO:0000250|UniProtKB:P02747}. Note=Specifically binds IgG or IgM immunoglobulins complexed with antigens, forming antigen-antibody complexes on the surface of pathogens. {ECO:0000250|UniProtKB:P02747}.
uniprot
proteins