Myl2
entrez
17906
canonical
uniprot
P51667
canonical
ensembl
ENSMUSG00000013936
resolver
ensp
ENSMUSP00000014080
resolver
ensp
ENSMUSP00000107380
resolver
enst
ENSMUST00000014080
resolver
enst
ENSMUST00000111751
resolver
genesymbol
Myl2
resolver
genesymbol_syn
Mylpc
resolver
uniprot
Q6P8P4
resolver
uniprot
Q9QVP3
resolver
uniprot_entry
MLRV_MOUSE
resolver
uniprot_sec
Q6P8P4
resolver
uniprot_sec
Q9QVP3
resolver
amino_acid_sequence
MAPKKAKKRIEGGSSNVFSMFEQTQIQEFKEAFTIMDQNRDGFIDKNDLRDTFAALGRVNVKNEEIDEMIKEAPGPINFTVFLTMFGEKLKGADPEETILNAFKVFDPEGKGSLKADYVREMLTTQAERFSKEEIDQMFAAFPPDVTGNLDYKNLVHIITHGEEKD
uniprot
proteins
function
FUNCTION: Contractile protein that plays a role in heart development and function (PubMed:10409661). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity) (PubMed:10409661, PubMed:16908724, PubMed:22426213). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (PubMed:9422794). {ECO:0000250|UniProtKB:P08733, ECO:0000269|PubMed:10409661, ECO:0000269|PubMed:16908724, ECO:0000269|PubMed:22426213, ECO:0000269|PubMed:9422794}.
uniprot
proteins
mass_dalton
18864
uniprot
proteins
mutagenesis
MUTAGEN 14; /note="S->A: Loss of cardiac myofibril assembly; when associated with A-15 and A-19. Loss of phosphorylation; when associated with A-15 and A-19. Loss of calcium sensitivity of force development; when associated with A-15 and A-19. Phosphorylation at Ser-19; when associated with A-15. Significant decrease in phosphorylation by MLCK; when associated with A-15. Adult lethality associated with early defects in cardiac twitch relaxation and torsion leading to dilated cardiomyopathy, heart failure and premature death; when associated with A-15. Significant acceleration of twitch relaxation in absence of changes in calcium transients; when associated with A-15. Absence of transmural phosphorylation gradient leading to alteration of torsion; when associated with A-14."; /evidence="ECO:0000269|PubMed:10409661, ECO:0000269|PubMed:22426213"; MUTAGEN 15; /note="S->A: Loss of cardiac myofibril assembly; when associated with A-14 and A-19. Loss of phosphorylation; when associated with A-14 and A-19. Loss of calcium sensitivity of force development; when associated with A-14 and A-19. Increase of phosphorylation. Phosphorylation at Ser-14 and at Ser-19. Phosphorylation at Ser-19; when associated with A-14. Significant decrease in phosphorylation by MLCK; when associated with A-14. Adult lethality associated with early defects in cardiac twitch relaxation and torsion leading to dilated cardiomyopathy, heart failure and premature death; when associated with A-14. Significant acceleration of twitch relaxation in absence of changes in calcium transients; when associated with A-14. Absence of transmural phosphorylation gradient leading to alteration of torsion; when associated with A-14."; /evidence="ECO:0000269|PubMed:10409661, ECO:0000269|PubMed:22426213"; MUTAGEN 19; /note="S->A: Loss of cardiac myofibril assembly; when associated with A-14 and A-15. Loss of phosphorylation; when associated with A-14 and A-15. Loss of calcium sensitivity of force development; when associated with A-14 and A-15."; /evidence="ECO:0000269|PubMed:10409661
uniprot
proteins
post_translational_modification
PTM: N-terminus is methylated by METTL11A/NTM1. {ECO:0000269|PubMed:20668449}.; PTM: Phosphorylated by MYLK3 and MYLK2; promotes cardiac muscle contraction and function. Dephosphorylated by PPP1CB complexed to PPP1R12B (By similarity). The phosphorylated form in adult is expressed as gradients across the heart from endocardium (low phosphorylation) to epicardium (high phosphorylation); regulates cardiac torsion and workload distribution (PubMed:22426213). {ECO:0000250|UniProtKB:P08733, ECO:0000269|PubMed:22426213, ECO:0000269|PubMed:23095280}.
uniprot
proteins
pubmed
10409661
uniprot
proteins
pubmed
1379240
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16908724
uniprot
proteins
pubmed
20038585
uniprot
proteins
pubmed
20445002
uniprot
proteins
pubmed
20668449
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22426213
uniprot
proteins
pubmed
23095280
uniprot
proteins
pubmed
8506363
uniprot
proteins
pubmed
9422794
uniprot
proteins
sequence_length
166
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, A band {ECO:0000250|UniProtKB:P08733}.
uniprot
proteins