Tmem63a
entrez
208795
canonical
uniprot
Q91YT8
canonical
ensembl
ENSMUSG00000026519
resolver
ensp
ENSMUSP00000027800
resolver
ensp
ENSMUSP00000124021
resolver
ensp
ENSMUSP00000305916
resolver
ensp
ENSMUSP00000305918
resolver
enst
ENSMUST00000027800
resolver
enst
ENSMUST00000161523
resolver
genesymbol
Tmem63a
resolver
genesymbol_syn
Kiaa0792
resolver
uniprot
Q3TCS5
resolver
uniprot
Q69ZZ1
resolver
uniprot_entry
TM63A_MOUSE
resolver
uniprot_sec
Q3TCS5
resolver
uniprot_sec
Q69ZZ1
resolver
amino_acid_sequence
MTSSPFLDPWPSKAVFVRERLGLGERPNDSYCYNSAKNSTVLQGVTFGGIPTVLLLDVSCFLFLILVFSIIRRRFWDYGRIALVSEAGSEARFQRLSSSSSGQQDFENELGCCPWLTAIFRLHDDQILEWCGEDAIHYLSFQRHIIFLLVVISFLSLCVILPVNLSGDLLGKDPYSFGRTTIANLQTDNDLLWLHTVFSVIYLFLTVGFMWHHTRSIRYKEESLVRQTLFITGLPREARKETVESHFRDAYPTCEVVDVQLCYSVAKLIYLCKERKKTEKSLTYYTNLQAKTGRRTLINPKPCGQFCCCEVQGCEREDAISYYTRMNDSLLERITAEESRVQDQPLGMAFVTFREKSMATYILKDFNACKCQGLRCKGEPQPSSYSRELCVSKWTVTFASYPEDICWKNLSIQGVRWWLQWLGINFSLFVVLFFLTTPSIIMSTMDKFNVTKPIHALNNPVISQFFPTLLLWSFSALLPSIVYYSTLLESHWTRSGENRIMVSKVYIFLIFMVLILPSLGLTSLDFFFRWLFDKTSSETSIRLECVFLPDQGAFFVNYVIASAFIGSGMELLRLPGLILYTFRMIMAKTAADRRNVKQNQAFEYEFGAMYAWMLCVFTVIMAYSITCPIIVPFGLIYILLKHMVDRHNLYFAYLPAKLEKRIHFAAVNQALAAPILCLFWLFFFSFLRLGLTAPATLFTFLVVLLTILACLLYTCFGCFKHLSPWNYKTEESASDKGSEAEAHVPPPFTPYVPRILNGLASERTALSPQQQQTYGAIRNISGTLPGQPVAQDPSGTAAYAYQES
uniprot
proteins
function
FUNCTION: Mechanosensitive cation channel with low conductance and high activation threshold (PubMed:30382938, PubMed:37543036). In contrast to TMEM63B, does not show phospholipid scramblase activity (By similarity). Acts as a regulator of lysosomal morphology by mediating lysosomal mechanosensitivity (PubMed:38388853). Important for the baby's first breath and respiration throughout life (PubMed:38127458). Upon lung inflation conducts cation currents in alveolar type 1 and 2 cells triggering lamellar body exocytosis and surfactant secretion into airspace (PubMed:38127458). Also acts as an osmosensitive cation channel preferentially activated by hypotonic stress (PubMed:27045885, PubMed:32375046). {ECO:0000250|UniProtKB:O94886, ECO:0000269|PubMed:27045885, ECO:0000269|PubMed:30382938, ECO:0000269|PubMed:32375046, ECO:0000269|PubMed:37543036, ECO:0000269|PubMed:38127458, ECO:0000269|PubMed:38388853}.
uniprot
proteins
mass_dalton
91860
uniprot
proteins
mutagenesis
MUTAGEN 472; /note="W->K: Converts the channel into a constitutively active phospholipid scramblase."; /evidence="ECO:0000269|PubMed:39495104"; MUTAGEN 475; /note="S->K: Converts the channel into a constitutively active phospholipid scramblase."; /evidence="ECO:0000269|PubMed:39495104"; MUTAGEN 476; /note="A->K: Does not convert the channel into a phospholipid scramblase."; /evidence="ECO:0000269|PubMed:39495104
uniprot
proteins
post_translational_modification
PTM: N-Glycosylated. {ECO:0000250|UniProtKB:O94886}.
uniprot
proteins
protein_family
CSC1 (TC 1.A.17) family
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27045885
uniprot
proteins
pubmed
30382938
uniprot
proteins
pubmed
32375046
uniprot
proteins
pubmed
37543036
uniprot
proteins
pubmed
38127458
uniprot
proteins
pubmed
38388853
uniprot
proteins
pubmed
39495104
uniprot
proteins
sequence_length
804
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:38388853}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:O94886}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:27045885, ECO:0000269|PubMed:30382938, ECO:0000269|PubMed:37543036}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 52..74; /note="Helical; Name=TM0"; /evidence="ECO:0000250|UniProtKB:O94886"; TRANSMEM 134..166; /note="Helical; Name=TM1"; /evidence="ECO:0000250|UniProtKB:O94886"; TRANSMEM 191..216; /note="Helical; Name=TM2"; /evidence="ECO:0000250|UniProtKB:O94886"; TRANSMEM 416..443; /note="Helical; Name=TM3"; /evidence="ECO:0000250|UniProtKB:O94886"; TRANSMEM 462..489; /note="Helical; Name=TM4"; /evidence="ECO:0000250|UniProtKB:O94886"; TRANSMEM 495..531; /note="Helical; Name=TM5"; /evidence="ECO:0000250|UniProtKB:O94886"; TRANSMEM 554..585; /note="Helical; Name=TM6"; /evidence="ECO:0000250|UniProtKB:O94886"; TRANSMEM 606..623; /note="Helical; Name=TM7"; /evidence="ECO:0000250|UniProtKB:O94886"; TRANSMEM 628..650; /note="Helical; Name=TM8"; /evidence="ECO:0000250|UniProtKB:O94886"; TRANSMEM 661..688; /note="Helical; Name=TM9"; /evidence="ECO:0000250|UniProtKB:O94886"; TRANSMEM 694..708; /note="Helical; Name=TM10"; /evidence="ECO:0000250|UniProtKB:O94886
uniprot
proteins