Tle6
entrez
114606
canonical
uniprot
Q9WVB3
canonical
ensembl
ENSMUSG00000034758
resolver
ensp
ENSMUSP00000071905
resolver
ensp
ENSMUSP00000117287
resolver
enst
ENSMUST00000072020
resolver
enst
ENSMUST00000142948
resolver
genesymbol
Tle6
resolver
genesymbol_syn
Grg6
resolver
uniprot
D3Z5E1
resolver
uniprot
Q80XH3
resolver
uniprot_entry
D3Z5E1_MOUSE
resolver
uniprot_entry
Q80XH3_MOUSE
resolver
uniprot_entry
TLE6_MOUSE
resolver
amino_acid_sequence
MTSHRQSSDTFGGILPSTLSSRYLSIVNQLPEEFSSVVSEMMVHLENIFSLAENFFQAIERFSRTPDLLERNKMSIGVGAEGDSWPCHVSHEAPMGSAQTTENSAKEEDKQVPESAALQHPKFKSTPGPQLPTRRRFLSESDELQDPQPVWDAEPQFCQGFLIQGLWELFMDSRQKNQQEHGGEDSSQESKDSGLCDFKPEPQPRHRNSLSDSADPFLIKSPSALLDYYQEDVSRPQPETQESSGRADKFLKPLSWGSEVLESSCNQPSTALWQLERFTVPQALQKVRVLKHQELLLVVAVSSFTRHVFTCSQSGIKVWNLVNQVAEDRDPESHLKCSVQDNKVYLRTCLLSSNSRTLFAGGYNLPGVIVWDLAAPSLYEKCQLPCEGLSCQALANTKENMALAGFTDGTVRIWDLRTQEIVRNLKGPTNSARNLVVKDDNIWTGGLDACLRCWDLRMAKVSLEHLFQSQIMSLAHSPTEDWLLLGLANGQHCLFNSRKRDQVLTVDTKDNTILGLKFSPNGKWWASVGMGNFITVHSMPTGAKLFQVPEVGPVRCFDMTENGRLIITGSRDCASVYHIKY
uniprot
proteins
function
FUNCTION: Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development (PubMed:18804437, PubMed:25208553, PubMed:31575650, PubMed:37922900). The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos (PubMed:31575650, PubMed:37922900, PubMed:41845018, PubMed:41917274, PubMed:41986725). They are required to store maternal proteins critical for embryonic development, such as ribosomal proteins, cytoskeletal tubulins and proteins controlling epigenetic reprogramming of the preimplantation embryo, in a poised but restrained state, regulating their availability for early embryonic development (PubMed:37922900, PubMed:41845018, PubMed:41917274, PubMed:41986725). Cytoplasmic lattices also tightly control ubiquitination during the oocyte-to-embryo transition by trapping E3 ubiquitin-protein ligase UHRF1 in a compact autoinhibited conformation and maintaining SCF ubiquitin ligase complexes inactive (PubMed:41845018, PubMed:41917274, PubMed:41986725). TLE6 is also required for spermatogenesis: regulates spermatogonia proliferation and cell cycle progression, potentially via regulation of cell cycle regulatory genes such as; CEBPB, CEBPA, CSF3, PCNA, and CDK4 (PubMed:32823735, PubMed:39512902). Suppresses FOXG1/BF-1-mediated transcriptional repression by inhibiting interaction of the transcriptional corepressor TLE1 with FOXG1 which promotes cortical neuron differentiation (PubMed:16314515). Acts as a transcriptional corepressor of NFATC1-mediated gene expression by contributing to PAX6-mediated repression (PubMed:23990468). {ECO:0000269|PubMed:16314515, ECO:0000269|PubMed:18804437, ECO:0000269|PubMed:23990468, ECO:0000269|PubMed:25208553, ECO:0000269|PubMed:31575650, ECO:0000269|PubMed:32823735, ECO:0000269|PubMed:37922900, ECO:0000269|PubMed:39512902, ECO:0000269|PubMed:41845018, ECO:0000269|PubMed:41917274, ECO:0000269|PubMed:41986725}.
uniprot
proteins
mass_dalton
65116
uniprot
proteins
mutagenesis
MUTAGEN 305; /note="T->R: Impaired formation of the subcortical maternal complex (SCMC)."; /evidence="ECO:0000269|PubMed:38177687"; MUTAGEN 365; /note="L->P: Impaired formation of the subcortical maternal complex (SCMC)."; /evidence="ECO:0000269|PubMed:38177687"; MUTAGEN 519; /note="S->Y: Impaired formation of the subcortical maternal complex (SCMC)."; /evidence="ECO:0000269|PubMed:38177687"; MUTAGEN 550; /note="E->K: Impaired formation of the subcortical maternal complex (SCMC)."; /evidence="ECO:0000269|PubMed:38177687
uniprot
proteins
protein_family
WD repeat Groucho/TLE family
uniprot
proteins
pubmed
11486032
uniprot
proteins
pubmed
16314515
uniprot
proteins
pubmed
18254933
uniprot
proteins
pubmed
18804437
uniprot
proteins
pubmed
23990468
uniprot
proteins
pubmed
25208553
uniprot
proteins
pubmed
28992324
uniprot
proteins
pubmed
31575650
uniprot
proteins
pubmed
32823735
uniprot
proteins
pubmed
37922900
uniprot
proteins
pubmed
38177687
uniprot
proteins
pubmed
39512902
uniprot
proteins
pubmed
41118754
uniprot
proteins
pubmed
41845018
uniprot
proteins
pubmed
41917274
uniprot
proteins
pubmed
41986725
uniprot
proteins
sequence_length
581
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16314515, ECO:0000269|PubMed:18804437, ECO:0000269|PubMed:37922900}. Nucleus {ECO:0000269|PubMed:16314515}. Note=Core component of cytoplasmic lattices in oocytes (PubMed:37922900). In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages (PubMed:18804437, PubMed:25208553). At the 2-cell and morular stage, still detected in the subcortex, but excluded from cell-cell contact regions (PubMed:18804437, PubMed:25208553). Expression largely disappears in blastocysts (PubMed:25208553). {ECO:0000269|PubMed:18804437, ECO:0000269|PubMed:25208553, ECO:0000269|PubMed:37922900}.
uniprot
proteins