Cyp4f3
entrez
72054
canonical
uniprot
Q99N16
canonical
ensembl
ENSMUSG00000003484
resolver
ensp
ENSMUSP00000003574
resolver
ensp
ENSMUSP00000311965
resolver
ensp
ENSMUSP00000356962
resolver
enst
ENSMUST00000003574
resolver
genesymbol
Cyp4f3
resolver
genesymbol_syn
Cyp4f18
resolver
uniprot
E9QLZ3
resolver
uniprot
Q9D8N4
resolver
uniprot_entry
CP4F3_MOUSE
resolver
uniprot_sec
E9QLZ3
resolver
uniprot_sec
Q9D8N4
resolver
amino_acid_sequence
MSQLSMSWMGLGHTAASPWLLLLLAGASCLLAYILTPIYGVFENSLRLRCFPQPPKRNWILGHLGLIQSSEEGLLYIQSLVRTFRDACCWWVGPLHPVIRIFHPAFIKPVVLAPALVAPKDTVFYRFLKPWLGDGLLMSTGDKWSRHRRMLTPAFHFNILKPYVKVFNDSTNIMHAKWQRLASKGSAYLNMFEHISLMTLDSLQKCVFSFDSNCQEKPSEYITAILELSTLVARRHQRLLLHVDLFYYLTHDGMRFRKACRLVHDFTDAVIRERRRTLLDQGGVDVLKAKAKAKTLDFIDVLLLSKDEHGKALSDEDIRAEADTFMFGGHDTTASGLSWILYNLARHPEYQERCRQEVRELLRDREPEEIEWDDLAQLPFLTMCIKESLRLHPPVTAISRCCTQDIVLPDGRVIPKGVISRISIFGTHHNPAVWPDPEVYDPFRFDADNVKGRSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRVLPDDKEPRRKPELILRAEGGLWLKVEPLSAGAQ
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of the pro-inflammatory lipid mediator leukotriene B4 (LTB4) (PubMed:16380383, PubMed:24632148). Hydroxylates at the omega-1 and omega-2 positions LTB4. This oxidation step leads to LTB4 inactivation, which is postulated to be a crucial part of the resolution of inflammation (PubMed:16380383, PubMed:24632148). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase) (PubMed:16380383, PubMed:24632148). {ECO:0000269|PubMed:16380383, ECO:0000269|PubMed:24632148}.
uniprot
proteins
mass_dalton
59843
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; leukotriene B4 degradation. {ECO:0000269|PubMed:16380383, ECO:0000269|PubMed:24632148}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16380383
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24632148
uniprot
proteins
sequence_length
524
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305|PubMed:16380383}; Single-pass membrane protein {ECO:0000305}. Microsome membrane {ECO:0000305|PubMed:16380383}; Single-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 19..39; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins