FCRL6
entrez
343413
canonical
uniprot
Q6DN72
canonical
ensembl
ENSG00000181036
resolver
ensp
ENSP00000320625
resolver
ensp
ENSP00000357086
resolver
ensp
ENSP00000657918
resolver
genesymbol
FCRL6
resolver
genesymbol_syn
FCRH6
resolver
hgnc
HGNC:31910
resolver
uniprot
A1KXW6
resolver
uniprot
A2A4D6
resolver
uniprot
Q6DN73
resolver
uniprot
Q6XRC3
resolver
uniprot
Q6ZNI1
resolver
uniprot_entry
FCRL6_HUMAN
resolver
uniprot_sec
A1KXW6
resolver
uniprot_sec
A2A4D6
resolver
uniprot_sec
Q6DN73
resolver
uniprot_sec
Q6XRC3
resolver
uniprot_sec
Q6ZNI1
resolver
amino_acid_sequence
MLLWTAVLLFVPCVGKTVWLYLQAWPNPVFEGDALTLRCQGWKNTPLSQVKFYRDGKFLHFSKENQTLSMGAATVQSRGQYSCSGQVMYIPQTFTQTSETAMVQVQELFPPPVLSAIPSPEPREGSLVTLRCQTKLHPLRSALRLLFSFHKDGHTLQDRGPHPELCIPGAKEGDSGLYWCEVAPEGGQVQKQSPQLEVRVQAPVSRPVLTLHHGPADPAVGDMVQLLCEAQRGSPPILYSFYLDEKIVGNHSAPCGGTTSLLFPVKSEQDAGNYSCEAENSVSRERSEPKKLSLKGSQVLFTPASNWLVPWLPASLLGLMVIAAALLVYVRSWRKAGPLPSQIPPTAPGGEQCPLYANVHHQKGKDEGVVYSVVHRTSKRSEARSAEFTVGRKDSSIICAEVRCLQPSEVSSTEVNMRSRTLQEPLSDCEEVLC
uniprot
proteins
function
FUNCTION: Acts as a MHC class II receptor (PubMed:20519654). When stimulated on its own, does not play a role in cytokine production or the release of cytotoxic granules by NK cells and cytotoxic CD8(+) T cells (PubMed:17213291, PubMed:18991291). Does not act as an Fc receptor (PubMed:18991291). {ECO:0000269|PubMed:17213291, ECO:0000269|PubMed:18991291, ECO:0000269|PubMed:20519654}.
uniprot
proteins
mass_dalton
47748
uniprot
proteins
mutagenesis
MUTAGEN 356; /note="Y->F: No change of phosphorylation implicated in interaction with PTPN11. Loss of interaction with INPPD5, INPPL1 and GRB2."; /evidence="ECO:0000269|PubMed:17213291, ECO:0000269|PubMed:20933011"; MUTAGEN 371; /note="Y->F: Loss of phosphorylation implicated in interaction with PTPN11. Loss of interaction with PTPN11, PTPN6 and INPPL1."; /evidence="ECO:0000269|PubMed:17213291, ECO:0000269|PubMed:20933011
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Tyr residues. Tyrosine phosphorylation induces association with phosphatase PTPN11, PTPN6, INPP5D, INPPL1 and GRB2. {ECO:0000269|PubMed:17213291, ECO:0000269|PubMed:18991291}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17213291
uniprot
proteins
pubmed
18991291
uniprot
proteins
pubmed
20519654
uniprot
proteins
pubmed
20933011
uniprot
proteins
sequence_length
434
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18991291, ECO:0000269|PubMed:20933011}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 308..328; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins