SLC24A4
entrez
123041
canonical
uniprot
Q8NFF2
canonical
ensembl
ENSG00000140090
resolver
ensp
ENSP00000376948
resolver
ensp
ENSP00000431840
resolver
ensp
ENSP00000433302
resolver
ensp
ENSP00000502715
resolver
genesymbol
SLC24A4
resolver
genesymbol_syn
NCKX4
resolver
hgnc
HGNC:10978
resolver
uniprot
B4DHE7
resolver
uniprot
B9ZVY2
resolver
uniprot
Q8N8U6
resolver
uniprot
Q8NCX1
resolver
uniprot
Q8NFF0
resolver
uniprot
Q8NFF1
resolver
uniprot_entry
NCKX4_HUMAN
resolver
uniprot_sec
B4DHE7
resolver
uniprot_sec
B9ZVY2
resolver
uniprot_sec
Q8N8U6
resolver
uniprot_sec
Q8NCX1
resolver
uniprot_sec
Q8NFF0
resolver
uniprot_sec
Q8NFF1
resolver
amino_acid_sequence
MALRGTLRPLKVRRRREMLPQQVGFVCAVLALVCCASGLFGSLGHKTASASKRVLPDTWRNRKLMAPVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAVLLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIGVFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVFIYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAFFTVKQKSIANGNPVNSELEAGNDFYDGSYDDPSVPLLGQVKEKPQYGKNPVVMVDEIMSSSPPKFTFPEAGLRIMITNKFGPRTRLRMASRIIINERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLPMCREDD
uniprot
proteins
disease_involvement
DISEASE: Amelogenesis imperfecta, hypomaturation type, 2A5 (AI2A5) [MIM:615887]: A defect of enamel formation. The disorder involves both primary and secondary dentitions. The teeth have a shiny agar jelly appearance and the enamel is softer than normal. Brown pigment is present in middle layers of enamel. {ECO:0000269|PubMed:23375655, ECO:0000269|PubMed:24621671, ECO:0000269|PubMed:25442250, ECO:0000269|PubMed:32034543, ECO:0000269|PubMed:32380970, ECO:0000269|PubMed:35055328}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (PubMed:12379639, PubMed:26631410). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived (By similarity). May play a role in calcium transport during amelogenesis (PubMed:23375655, PubMed:24621671). {ECO:0000250|UniProtKB:Q8CGQ8, ECO:0000269|PubMed:12379639, ECO:0000269|PubMed:23375655, ECO:0000269|PubMed:24621671, ECO:0000269|PubMed:26631410}.
uniprot
proteins
mass_dalton
69042
uniprot
proteins
protein_family
Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family
uniprot
proteins
protein_family
SLC24A subfamily
uniprot
proteins
pubmed
12379639
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17952075
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
23375655
uniprot
proteins
pubmed
24621671
uniprot
proteins
pubmed
25442250
uniprot
proteins
pubmed
26631410
uniprot
proteins
pubmed
32034543
uniprot
proteins
pubmed
32380970
uniprot
proteins
pubmed
35055328
uniprot
proteins
sequence_length
622
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26631410}; Multi-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:Q8CGQ8}.
uniprot
proteins
transmembrane_region
TRANSMEM 98..118; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 143..163; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 173..193; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 201..221; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 225..245; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 458..478; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 480..500; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 527..547; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 558..578; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 587..607; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins