Mpzl1
entrez
68481
canonical
uniprot
Q3TEW6
canonical
ensembl
ENSMUSG00000026566
resolver
ensp
ENSMUSP00000070343
resolver
ensp
ENSMUSP00000107062
resolver
ensp
ENSMUSP00000142164
resolver
enst
ENSMUST00000068705
resolver
enst
ENSMUST00000194437
resolver
genesymbol
Mpzl1
resolver
genesymbol_syn
Pzr
resolver
uniprot
A0A0A6YXW1
resolver
uniprot
A0A0R4J0V2
resolver
uniprot
Q2VW02
resolver
uniprot
Q6GQX5
resolver
uniprot_entry
A0A0A6YXW1_MOUSE
resolver
uniprot_entry
A0A0R4J0V2_MOUSE
resolver
uniprot_entry
MPZL1_MOUSE
resolver
uniprot_sec
Q2VW02
resolver
uniprot_sec
Q6GQX5
resolver
amino_acid_sequence
MAEAVGAVALIAAPARRRWLWSVLAAMLGLLTARISALEVHTPKEIFVVNGTQGKLTCTFDSPNTTGWLTTVSWSFQPDGTDSAVSFFHYSQGQVYIGDYPPFKDRVTWAGDLDKKDASINIENIQAVHNGTYICDVKNPPDIVVRPGHIRLHVVEIDNLLVFLVWVVVGTVTAVVLGLTLLISLVLVVLYRRKHSKRDYTGCSTSERLSPVKQAPRKCPSDTEGLVKSPPSAGSHQGPVIYAQLDHSGGHHSGKINKSESVVYADIRKD
uniprot
proteins
function
FUNCTION: Cell surface receptor, which is involved in signal transduction processes. Recruits PTPN11/SHP-2 to the cell membrane and is a putative substrate of PTPN11/SHP-2. Is a major receptor for concanavalin-A (ConA) and is involved in cellular signaling induced by ConA, which probably includes Src family tyrosine-protein kinases. Isoform 2 seems to have a dominant negative role; it blocks tyrosine phosphorylation of MPZL1 induced by ConA. Isoform 1, but not isoform 2, may be involved in regulation of integrin-mediated cell motility (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
29495
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues upon stimulation with pervanadate and concanavalin-A (ConA). Phosphorylation at Tyr-242 and Tyr-264 is required for interaction with PTPN11/SHP-2. Dephosphorylated by PTPN11/SHP-2 (in vitro) (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Myelin P0 protein family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19349973
uniprot
proteins
sequence_length
270
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 163..183; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins