Syt4
entrez
64440
canonical
uniprot
P50232
canonical
ensembl
ENSRNOG00000017333
resolver
ensembl
ENSRNOG00055024114
resolver
ensembl
ENSRNOG00060026793
resolver
ensembl
ENSRNOG00065012162
resolver
ensp
ENSRNOP00000023593
resolver
ensp
ENSRNOP00055033718
resolver
ensp
ENSRNOP00060038597
resolver
ensp
ENSRNOP00065015144
resolver
enst
ENSRNOT00000023594
resolver
enst
ENSRNOT00055041439
resolver
enst
ENSRNOT00060046438
resolver
enst
ENSRNOT00065019770
resolver
genesymbol
Syt4
resolver
uniprot_entry
SYT4_RAT
resolver
amino_acid_sequence
MAPITTSRVEFDEIPTVVGIFSAFGLVFTVSLFAWICCQRRSAKSNKTPPYKFVHVLKGVDIYPENLSSKKKFGGDDKSEAKRKAALPNLSLHLDLEKRDLNGNFPKTNPKAGSSSDLENVTPKLFPETEKEAVSPESLKSSTSLTSEEKQEKLGTLFLSLEYNFEKKAFVVNIKEAQGLPAMDEQSMTSDPYIKMTILPEKKHKVKTRVLRKTLDPVFDETFTFYGVPYPHIQELSLHFTVLSFDRFSRDDVIGEVLVPLSGIELSDGKMLMTREIIKRNAKKSSGRGELLVSLCYQSTTNTLTVVVLKARHLPKSDVSGLSDPYVKVNLYHAKKRISKKKTHVKKCTPNAVFNELFVFDIPCESLEEISVEFLVLDSERGSRNEVIGRLVLGATAEGSGGGHWKEICDFPRRQIAKWHMLCDG
uniprot
proteins
function
FUNCTION: Synaptotagmin family member which does not bind Ca(2+) (PubMed:7993622). Involved in neuronal dense core vesicles (DCVs) mobility through its interaction with KIF1A. Upon increased neuronal activity, phosphorylation by MAPK8/JNK1 destabilizes the interaction with KIF1A and captures DCVs to synapses (PubMed:29166604). Plays a role in dendrite formation by melanocytes (By similarity). {ECO:0000250|UniProtKB:Q9H2B2, ECO:0000269|PubMed:29166604, ECO:0000269|PubMed:7993622}.
uniprot
proteins
mass_dalton
47685
uniprot
proteins
mutagenesis
MUTAGEN 135; /note="S->A: Increases interaction with KIF1A. Abolishes neuronal dense core vesicles mobility inhibition."; /evidence="ECO:0000269|PubMed:29166604"; MUTAGEN 135; /note="S->E: Decreases interaction with KIF1A. Inhibits neuronal dense core vesicles mobility."; /evidence="ECO:0000269|PubMed:29166604"; MUTAGEN 244; /note="S->D: Restores Ca(2+)-binding and Ca(2+)-dependent phospholipid binding."; /evidence="ECO:0000269|PubMed:9162066
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-135 by MAPK8/JNK1 reduces interaction with KIF1A and neuronal dense core vesicles mobility. {ECO:0000269|PubMed:29166604}.
uniprot
proteins
protein_family
Synaptotagmin family
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
29166604
uniprot
proteins
pubmed
30021165
uniprot
proteins
pubmed
7892240
uniprot
proteins
pubmed
7993622
uniprot
proteins
pubmed
9162066
uniprot
proteins
sequence_length
425
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane {ECO:0000269|PubMed:29166604, ECO:0000305|PubMed:30021165}; Single-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 17..37; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins