DDIT4
entrez
54541
canonical
uniprot
Q9NX09
canonical
ensembl
ENSG00000168209
resolver
ensp
ENSP00000307305
resolver
ensp
ENSP00000506356
resolver
ensp
ENSP00000541295
resolver
enst
ENST00000307365
resolver
enst
ENST00000491934
resolver
enst
ENST00000871236
resolver
genesymbol
DDIT4
resolver
genesymbol_syn
REDD1
resolver
genesymbol_syn
RTP801
resolver
hgnc
HGNC:24944
resolver
uniprot
Q9H0S3
resolver
uniprot_entry
DDIT4_HUMAN
resolver
uniprot_sec
Q9H0S3
resolver
amino_acid_sequence
MPSLWDRFSSSSTSSSPSSLPRTPTPDRPPRSAWGSATREEGFDRSTSLESSDCESLDSSNSGFGPEEDTAYLDGVSLPDFELLSDPEDEHLCANLMQLLQESLAQARLGSRRPARLLMPSQLVSQVGKELLRLAYSEPCGLRGALLDVCVEQGKSCHSVGQLALDPSLVPTFQLTLVLRLDSRLWPKIQGLFSSANSPFLPGFSQSLTLSTGFRVIKKKLYSSEQLLIEEC
uniprot
proteins
function
FUNCTION: Regulates cell growth, proliferation and survival via inhibition of the activity of the mammalian target of rapamycin complex 1 (mTORC1). Inhibition of mTORC1 is mediated by a pathway that involves DDIT4/REDD1, AKT1, the TSC1-TSC2 complex and the GTPase RHEB. Plays an important role in responses to cellular energy levels and cellular stress, including responses to hypoxia and DNA damage. Regulates p53/TP53-mediated apoptosis in response to DNA damage via its effect on mTORC1 activity. Its role in the response to hypoxia depends on the cell type; it mediates mTORC1 inhibition in fibroblasts and thymocytes, but not in hepatocytes (By similarity). Required for mTORC1-mediated defense against viral protein synthesis and virus replication (By similarity). Inhibits neuronal differentiation and neurite outgrowth mediated by NGF via its effect on mTORC1 activity. Required for normal neuron migration during embryonic brain development. Plays a role in neuronal cell death. {ECO:0000250, ECO:0000269|PubMed:15545625, ECO:0000269|PubMed:15632201, ECO:0000269|PubMed:15988001, ECO:0000269|PubMed:17005863, ECO:0000269|PubMed:17379067, ECO:0000269|PubMed:19557001, ECO:0000269|PubMed:20166753, ECO:0000269|PubMed:21460850}.
uniprot
proteins
mass_dalton
25371
uniprot
proteins
mutagenesis
MUTAGEN 19; /note="S->A: Strongly inhibits proteasomal degradation."; /evidence="ECO:0000269|PubMed:19557001"; MUTAGEN 23; /note="T->A: Strongly inhibits proteasomal degradation. Strongly inhibits proteasomal degradation; when associated with A-25."; /evidence="ECO:0000269|PubMed:19557001"; MUTAGEN 25; /note="T->A: Strongly inhibits proteasomal degradation; when associated with A-23."; /evidence="ECO:0000269|PubMed:19557001"; MUTAGEN 103; /note="S->L,W: No effect on inhibition of mTORC1."; /evidence="ECO:0000269|PubMed:20166753"; MUTAGEN 133; /note="R->A: No effect on inhibition of mTORC1."; /evidence="ECO:0000269|PubMed:20166753"; MUTAGEN 137; /note="S->A,D: No effect on inhibition of mTORC1."; /evidence="ECO:0000269|PubMed:20166753"; MUTAGEN 139; /note="P->A: Abolishes inhibition of mTORC1."; /evidence="ECO:0000269|PubMed:20166753"; MUTAGEN 140; /note="C->S: Mildly reduces inhibition of mTORC1."; /evidence="ECO:0000269|PubMed:20166753"; MUTAGEN 219; /note="K->A: Reduces inhibition of mTORC1. Abolishes inhibition of mTORC1; when associated with A-222."; /evidence="ECO:0000269|PubMed:20166753"; MUTAGEN 221; /note="L->A: Reduces inhibition of mTORC1."; /evidence="ECO:0000269|PubMed:20166753"; MUTAGEN 222; /note="Y->A: Reduces inhibition of mTORC1. Abolishes inhibition of mTORC1; when associated with A-219."; /evidence="ECO:0000269|PubMed:20166753
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by GSK3B; this promotes proteasomal degradation. {ECO:0000269|PubMed:19557001}.; PTM: Polyubiquitinated by a DCX (DDB1-CUL4A-RBX1) E3 ubiquitin-protein ligase complex with BTRC as substrate-recognition component, leading to its proteasomal degradation. {ECO:0000269|PubMed:19557001}.
uniprot
proteins
protein_family
DDIT4 family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
11884613
uniprot
proteins
pubmed
12453409
uniprot
proteins
pubmed
14646594
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15545625
uniprot
proteins
pubmed
15592522
uniprot
proteins
pubmed
15632201
uniprot
proteins
pubmed
15751966
uniprot
proteins
pubmed
15988001
uniprot
proteins
pubmed
17005863
uniprot
proteins
pubmed
17379067
uniprot
proteins
pubmed
19557001
uniprot
proteins
pubmed
20166753
uniprot
proteins
pubmed
21460850
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
232
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}. Cytoplasm, cytosol {ECO:0000269|PubMed:12453409}.
uniprot
proteins