Slc38a3
entrez
76257
canonical
uniprot
Q9DCP2
canonical
ensembl
ENSMUSG00000010064
resolver
ensp
ENSMUSP00000010208
resolver
ensp
ENSMUSP00000130414
resolver
ensp
ENSMUSP00000137561
resolver
ensp
ENSMUSP00000142087
resolver
ensp
ENSMUSP00000272991
resolver
ensp
ENSMUSP00000272994
resolver
ensp
ENSMUSP00000272996
resolver
enst
ENSMUST00000010208
resolver
enst
ENSMUST00000167868
resolver
enst
ENSMUST00000177567
resolver
enst
ENSMUST00000193932
resolver
genesymbol
Slc38a3
resolver
genesymbol_syn
Sn1
resolver
genesymbol_syn
Snat3
resolver
uniprot
Q8BS53
resolver
uniprot
Q9JLL8
resolver
uniprot_entry
S38A3_MOUSE
resolver
uniprot_sec
Q8BS53
resolver
uniprot_sec
Q9JLL8
resolver
amino_acid_sequence
MEIPRQTEMVELVPNGKHLEGLLPVGVPTTDTQRTEDTQHCGEGKGFLQKSPSKEPHFTDFEGKTSFGMSVFNLSNAIMGSGILGLAYAMANTGIILFLFLLTAVALLSSYSIHLLLKSSGIVGIRAYEQLGYRAFGTPGKLAAALAITLQNIGAMSSYLYIIKSELPLVIQTFLNLEKPASVWYMDGNYLVILVSVTIILPLALMRQLGYLGYSSGFSLSCMVFFLIAVIYKKFQVPCPLAHNLANATGNFSHMVVAEEKAQLQGEPDTAAEAFCTPSYFTLNSQTAYTIPIMAFAFVCHPEVLPIYTELKDPSKRKMQHISNLSIAVMYVMYFLAALFGYLTFYDGVESELLHTYSKVDPFDVLILCVRVAVLIAVTLTVPIVLFPVRRAIQQMLFQNQEFSWLRHVLIATGLLTCINLLVIFAPNILGIFGIIGATSAPCLIFIFPAIFYFRIMPTDKEPARSTPKILALCFAAVGFLLMTMSLSFIIIDWVSGTSQHGGNH
uniprot
proteins
function
FUNCTION: Symporter that cotransports specific neutral amino acids and sodium ions, coupled to an H(+) antiporter activity (PubMed:10716701, PubMed:15899884, PubMed:16249471, PubMed:18689705, PubMed:29561757, PubMed:30017230). Mainly participates in the glutamate-GABA-glutamine cycle in brain where it transports L-glutamine from astrocytes in the intercellular space for the replenishment of both neurotransmitters glutamate and gamma-aminobutyric acid (GABA) in neurons and also functions as the major influx transporter in ganglion cells mediating the uptake of glutamine (PubMed:18689705, PubMed:29561757, PubMed:30017230). The transport activity is specific for L-glutamine, L-histidine and L-asparagine (PubMed:10716701, PubMed:15899884, PubMed:16249471, PubMed:18689705, PubMed:29561757, PubMed:30017230). The transport is electroneutral coupled to the cotransport of 1 Na(+) and the antiport of 1 H(+) (By similarity). The transport is pH dependent, saturable, Li(+) tolerant and functions in both direction depending on the concentration gradients of its substrates and cotransported ions (PubMed:10716701, PubMed:16249471, PubMed:18689705). Also mediates an amino acid-gated H(+) conductance that is not stoichiometrically coupled to the amino acid transport but which influences the ionic gradients that drive the amino acid transport (By similarity). In addition, may play a role in nitrogen metabolism, amino acid homeostasis, glucose metabolism and renal ammoniagenesis (PubMed:26490457). {ECO:0000250|UniProtKB:Q9JHZ9, ECO:0000269|PubMed:10716701, ECO:0000269|PubMed:15899884, ECO:0000269|PubMed:16249471, ECO:0000269|PubMed:18689705, ECO:0000269|PubMed:26490457, ECO:0000269|PubMed:29561757, ECO:0000269|PubMed:30017230}.
uniprot
proteins
mass_dalton
55592
uniprot
proteins
mutagenesis
MUTAGEN 264..505; /note="Missing: Homozygous mice are lethal. Mice die between 18 and 20 days after birth. Mice are small, lethargic and ataxic."; /evidence="ECO:0000269|PubMed:26490457
uniprot
proteins
protein_family
Amino acid/polyamine transporter 2 family
uniprot
proteins
pubmed
10716701
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15899884
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16249471
uniprot
proteins
pubmed
18689705
uniprot
proteins
pubmed
19458124
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21364602
uniprot
proteins
pubmed
24854847
uniprot
proteins
pubmed
26490457
uniprot
proteins
pubmed
29561757
uniprot
proteins
pubmed
30017230
uniprot
proteins
pubmed
32046769
uniprot
proteins
sequence_length
505
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18689705, ECO:0000269|PubMed:30017230, ECO:0000269|PubMed:32046769}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:10716701}. Note=The localization appears to be basolateral in the plasma membrane of hepatocytes surrounding the central vein (PubMed:10716701). Localized at the cerebrospinal fluid (CSF)-facing membrane of the choroid plexus epithelial cells (PubMed:32046769). In astrocytes, the localization at cell membrane is decreased by ammonia through the PKC signaling (PubMed:30017230). Expressed in both luminal and abluminal plasma membranes of larger microvessels and blood brain barrier (BBB) capillaries (PubMed:21364602). Restricted to the basolateral membranes of S3 segment cells of the proximal tubules (By similarity). {ECO:0000250|UniProtKB:Q9JHZ9, ECO:0000269|PubMed:10716701, ECO:0000269|PubMed:21364602, ECO:0000269|PubMed:30017230, ECO:0000269|PubMed:32046769}.
uniprot
proteins
transmembrane_region
TRANSMEM 82..102; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 105..125; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 143..163; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 186..206; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 212..232; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 288..308; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 325..345; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 367..387; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 409..429; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 432..452; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 472..492; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins