Smad7
entrez
17131
canonical
uniprot
O35253
canonical
ensembl
ENSMUSG00000025880
resolver
ensp
ENSMUSP00000026999
resolver
ensp
ENSMUSP00000295725
resolver
genesymbol
Smad7
resolver
genesymbol_syn
Madh7
resolver
genesymbol_syn
Madh8
resolver
uniprot
B2RPW6
resolver
uniprot
O88709
resolver
uniprot_entry
B2RPW6_MOUSE
resolver
uniprot_entry
SMAD7_MOUSE
resolver
uniprot_sec
O88709
resolver
amino_acid_sequence
MFRTKRSALVRRLWRSRAPGGEDEEEGVGGGGGGGELRGEGATDGRAYGAGGGGAGRAGCCLGKAVRGAKGHHHPHPPTSGAGAAGGAEADLKALTHSVLKKLKERQLELLLQAVESRGGTRTACLLLPGRLDCRLGPGAPASAQPAQPPSSYSLPLLLCKVFRWPDLRHSSEVKRLCCCESYGKINPELVCCNPHHLSRLCELESPPPPYSRYPMDFLKPTAGCPDAVPSSAETGGTNYLAPGGLSDSQLLLEPGDRSHWCVVAYWEEKTRVGRLYCVQEPSLDIFYDLPQGNGFCLGQLNSDNKSQLVQKVRSKIGCGIQLTREVDGVWVYNRSSYPIFIKSATLDNPDSRTLLVHKVFPGFSIKAFDYEKAYSLQRPNDHEFMQQPWTGFTVQISFVKGWGQCYTRQFISSCPCWLEVIFNSR
uniprot
proteins
function
FUNCTION: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. {ECO:0000250|UniProtKB:O15105}.
uniprot
proteins
mass_dalton
46442
uniprot
proteins
mutagenesis
MUTAGEN 249; /note="S->A: No effect on stability, nuclear localization or inhibitory function in TGFB signaling. Abolishes transcriptional activity."; /evidence="ECO:0000269|PubMed:11278814"; MUTAGEN 249; /note="S->D: No effect."; /evidence="ECO:0000269|PubMed:11278814
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Ser-249 does not affect its stability, nuclear localization or inhibitory function in TGFB signaling; however it affects its ability to regulate transcription (PubMed:11278814). Phosphorylated by PDPK1 (By similarity). {ECO:0000250|UniProtKB:O15105, ECO:0000269|PubMed:11278814}.; PTM: Ubiquitinated by WWP1 (PubMed:15221015). Polyubiquitinated by RNF111, which is enhanced by AXIN1 and promotes proteasomal degradation (PubMed:14657019). In response to TGF-beta, ubiquitinated by SMURF1; which promotes its degradation (By similarity). Ubiquitinated by ARK2C, promoting proteasomal degradation, leading to enhance the BMP-Smad signaling (PubMed:23610558). {ECO:0000250|UniProtKB:O15105, ECO:0000269|PubMed:14657019, ECO:0000269|PubMed:15221015, ECO:0000269|PubMed:23610558}.; PTM: Acetylation prevents ubiquitination and degradation mediated by SMURF1. {ECO:0000250|UniProtKB:O15105}.
uniprot
proteins
protein_family
Dwarfin/SMAD family
uniprot
proteins
pubmed
10828018
uniprot
proteins
pubmed
11278814
uniprot
proteins
pubmed
14657019
uniprot
proteins
pubmed
15221015
uniprot
proteins
pubmed
15496141
uniprot
proteins
pubmed
23610558
uniprot
proteins
pubmed
9335507
uniprot
proteins
sequence_length
426
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11278814, ECO:0000269|PubMed:15496141}. Cytoplasm {ECO:0000269|PubMed:11278814, ECO:0000269|PubMed:15496141}. Note=Interaction with NEDD4L or RNF111 induces translocation from the nucleus to the cytoplasm (PubMed:15496141). TGF-beta stimulates its translocation from the nucleus to the cytoplasm. PDPK1 inhibits its translocation from the nucleus to the cytoplasm in response to TGF-beta (By similarity). {ECO:0000250|UniProtKB:O15105, ECO:0000269|PubMed:15496141}.
uniprot
proteins