Krt5
entrez
369017
canonical
uniprot
Q6P6Q2
canonical
ensembl
ENSRNOG00000050420
resolver
ensembl
ENSRNOG00055026015
resolver
ensembl
ENSRNOG00060016065
resolver
ensembl
ENSRNOG00065020971
resolver
ensp
ENSRNOP00000011644
resolver
ensp
ENSRNOP00055036801
resolver
ensp
ENSRNOP00060022102
resolver
ensp
ENSRNOP00065028706
resolver
enst
ENSRNOT00000011644
resolver
enst
ENSRNOT00055044901
resolver
enst
ENSRNOT00060027514
resolver
enst
ENSRNOT00065035612
resolver
genesymbol
Krt5
resolver
genesymbol_syn
Krt2-5
resolver
uniprot
Q7TN97
resolver
uniprot_entry
K2C5_RAT
resolver
uniprot_sec
Q7TN97
resolver
amino_acid_sequence
MSRQSSVSFRSGGSRSFSAASAITPSVSRTTFSSVSRSGGGGGRVSLGGAYGAGGYGSRSLYNVGGSKRISFSSGGGSFRNQFGAGAGGGYGFGGGAGSGFGFGGGAGSGFGFGGGAGFGGGYGGAGFPVCPPGGIQEVTVNQNLLTPLNLQIDPTIQRVRTEEREQIKTLNNKFASFIDKVRFLEQQNKVLDTKWTLLQEQGTKTIKQNLDPLFEQYINNLRRQLDGVMGERGRLDSELRNMQDLVEDYKNKYEDEINKRTTAENEFVMLKKDVDAAYMNKVELEAKVDALMDEINFMKMFFDAELSQMQTHVSDTSVVLSMDNNRSLDLDSIIAEVKAQYEDIANRSRTEAESWYQTKYEELQQTAGRHGDDLRNTKHEISEMNRMIQRLRSEIDNVKKQCANLQNAIAEAEQRGELALKDARNKLTELEEALQKAKQDMARLLREYQELMNTKLALDVEIATYRKLLEGEECRLSGEGVGPVNISVVTNSLSSGYGGRSNIGYGSGLGSGIGGFASDIGPLLNRRGLGSGLSVGGSGFSASSGQGGGFSSGGGSSSSVKFVSTTSSSRRSFKS
uniprot
proteins
function
FUNCTION: Structural component of intermediate filaments in basal keratinocytes of stratified epithelia. Forms heteropolymers with type I partners including KRT14 and KRT15, contributing to the formation of the keratin intermediate filament network that provides mechanical stability and resilience to the basal layer of the epidermis (By similarity). Regulates the recruitment of Langerhans cells to the epidermis, potentially by modulation of the abundance of macrophage chemotactic cytokines, macrophage inflammatory cytokines and CTNND1 localization in keratinocytes (By similarity). {ECO:0000250|UniProtKB:P13647, ECO:0000250|UniProtKB:Q922U2}.
uniprot
proteins
mass_dalton
61826
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CDK1, AURKB and Rho-kinase, phosphorylation is regulated by the cell cycle (By similarity). Thr-24 phosphorylation, mediated by CDK1, peaks during prometaphase or metaphase cells with phosphorylated filamentous structures evident throughout the cytoplasm during early mitosis (By similarity). CDK1 phosphorylates Thr-24 in mitotic cells at the site of injury (By similarity). {ECO:0000250|UniProtKB:Q922U2}.; PTM: O-glycosylated. {ECO:0000250|UniProtKB:Q922U2}.
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
14551252
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
576
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q922U2}.
uniprot
proteins