Hnrnpl
entrez
15388
canonical
uniprot
Q8R081
canonical
ensembl
ENSMUSG00000015165
resolver
ensp
ENSMUSP00000049407
resolver
ensp
ENSMUSP00000133728
resolver
ensp
ENSMUSP00000133932
resolver
ensp
ENSMUSP00000134734
resolver
ensp
ENSMUSP00000169554
resolver
ensp
ENSMUSP00000330621
resolver
enst
ENSMUST00000038572
resolver
enst
ENSMUST00000172529
resolver
enst
ENSMUST00000174548
resolver
genesymbol
Hnrnpl
resolver
genesymbol_syn
Hnrpl
resolver
uniprot
G3UY38
resolver
uniprot
O54789
resolver
uniprot
Q3UMT7
resolver
uniprot
Q499X2
resolver
uniprot
Q8K0S7
resolver
uniprot
Q9CVU5
resolver
uniprot_entry
G3UY38_MOUSE
resolver
uniprot_entry
HNRPL_MOUSE
resolver
uniprot_entry
Q3UMT7_MOUSE
resolver
uniprot_entry
Q9CVU5_MOUSE
resolver
uniprot_sec
O54789
resolver
uniprot_sec
Q499X2
resolver
uniprot_sec
Q8K0S7
resolver
amino_acid_sequence
MSRRLLPRAEKRRRRLEQRQQPDEQLRRAGAMVKMAAAGGGGGGGRYYGGGNEGGRAPKRLKTENAGDQHGGGGGGGSGAAGGGGGENYDDPHKTPASPVVHIRGLIDGVVEADLVEALQEFGPISYVVVMPKKRQALVEFEDVLGACNAVNYAADNQIYIAGHPAFVNYSTSQKISRPGDSDDSRSVNSVLLFTILNPIYSITTDVLYTICNPCGPVQRIVIFRKNGVQAMVEFDSVQSAQRAKASLNGADIYSGCCTLKIEYAKPTRLNVFKNDQDTWDYTNPNLSGQGDPGSNPNKRQRQPPLLGDHPAEYGGPHGGYHSHYHDEGYGPPPPHYEGRRMGPPVGGHRRGPSRYGPQYGHPPPPPPPPDYGPHADSPVLMVYGLDQSKMNCDRVFNVFCLYGNVEKVKFMKSKPGAAMVEMADGYAVDRAITHLNNNFMFGQKMNVCVSKQPAIMPGQSYGLEDGSCSYKDFSESRNNRFSTPEQAAKNRIQHPSNVLHFFNAPLEVTEENFFEICDELGVKRPTSVKVFSGKSERSSSGLLEWDSKSDALETLGFLNHYQMKNPNGPYPYTLKLCFSTAQHAS
uniprot
proteins
function
FUNCTION: Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion (PubMed:22523384). Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (By similarity). Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8. {ECO:0000250|UniProtKB:P14866, ECO:0000269|PubMed:22523384}.
uniprot
proteins
mass_dalton
63964
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the SCF-FBXO16 E3 ubiquitin ligase, leading to proteasomal degradation. {ECO:0000250|UniProtKB:P14866}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22523384
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
36537238
uniprot
proteins
sequence_length
586
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:P14866, ECO:0000305|PubMed:36537238}. Cytoplasm {ECO:0000250|UniProtKB:P14866}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. These granules are not identical with P bodies or stress granules. {ECO:0000250|UniProtKB:P14866}.
uniprot
proteins