P35242
uniprot
P35242
canonical
amino_acid_sequence
MSLGSLAFTLFLTVVAGIKCNGTEVCAGSPGIPGTPGNHGLPGRDGRDGIKGDPGPPGPMGPPGGMPGLPGRDGLPGAPGAPGEHGDKGEPGERGLPGFPAYLDEELQTASYEIKHQILQTMGVLSLQGSMLSVGDKVFSTNGQSVNFDTIREMCTRAGGHIAAPRNPEENEAIASITKKYNTYPYLGVIEGQTPGDFHYLDGASVNYTNWYPGEPRGRGKEKCVEMYTDGKWNDKGCLQYRLAICEF
uniprot
proteins
function
FUNCTION: In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages (PubMed:25965346). {ECO:0000269|PubMed:25965346}.
uniprot
proteins
mass_dalton
26157
uniprot
proteins
mutagenesis
MUTAGEN 208; /note="Y->H: Knockin homozygous mice develop progressive pulmonary fibrosis. The mutant protein is not secreted in bronchoalveolar fluid from mutant mice."; /evidence="ECO:0000269|PubMed:31601679
uniprot
proteins
protein_family
SFTPA family
uniprot
proteins
pubmed
1443158
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25965346
uniprot
proteins
pubmed
31601679
uniprot
proteins
sequence_length
248
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:31601679}. Secreted, extracellular space, extracellular matrix {ECO:0000305}. Secreted, extracellular space, surface film {ECO:0000305}.
uniprot
proteins