Acat1
entrez
25014
canonical
uniprot
P17764
canonical
ensembl
ENSRNOG00000007862
resolver
ensembl
ENSRNOG00055027672
resolver
ensembl
ENSRNOG00060016362
resolver
ensembl
ENSRNOG00065017528
resolver
ensp
ENSRNOP00000010573
resolver
ensp
ENSRNOP00055039493
resolver
ensp
ENSRNOP00060022580
resolver
ensp
ENSRNOP00065023265
resolver
enst
ENSRNOT00000010573
resolver
enst
ENSRNOT00055047965
resolver
enst
ENSRNOT00060028059
resolver
enst
ENSRNOT00065029319
resolver
genesymbol
Acat1
resolver
uniprot_entry
THIL_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by potassium ions, but not sodium ions. {ECO:0000250|UniProtKB:P24752}.
uniprot
proteins
amino_acid_sequence
MAALAVLHGVVRRPLLRGLLQEVRCLGRSYASKPTLNDVVIVSATRTPIGSFLGSLASQPATKLGTIAIQGAIEKAGIPKEEVKEVYMGNVIQGGEGQAPTRQATLGAGLPIATPCTTVNKVCASGMKAIMMASQSLMCGHQDVMVAGGMESMSNVPYVMSRGATPYGGVKLEDLIVKDGLTDVYNKIHMGNCAENTAKKLSISREEQDKYAIGSYTRSKEAWDAGKFANEITPITISVKGKPDVVVKEDEEYKRVDFSKVPKLKTVFQKENGTVTAANASTLNDGAAAVVLMTAEAAQRLKVKPLARIAAFADAAVDPIDFPLAPAYAVPKVLKYAGLKKEDIAMWEVNEAFSVVVLANIKMLEIDPQKVNVHGGAVSLGHPIGMSGARIVVHLAHALKQGEFGLASICNGGGGASAVLIEKL
uniprot
proteins
ec_number
2.3.1.9
uniprot
proteins
function
FUNCTION: This is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA. Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms. The activity of the enzyme is reversible and it can also catalyze the condensation of two acetyl-CoA molecules into acetoacetyl-CoA. Thereby, it plays a major role in ketone body metabolism. {ECO:0000250|UniProtKB:P24752}.
uniprot
proteins
mass_dalton
44695
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid beta-oxidation. {ECO:0000250|UniProtKB:P24752}.
uniprot
proteins
post_translational_modification
PTM: Succinylation at Lys-265, adjacent to a coenzyme A binding site. Desuccinylated by SIRT5 (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Thiolase family
uniprot
proteins
protein_family
Thiolase-like superfamily
uniprot
proteins
pubmed
2478525
uniprot
proteins
sequence_length
424
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P24752}.
uniprot
proteins