SOCS6
entrez
9306
canonical
uniprot
O14544
canonical
ensembl
ENSG00000170677
resolver
ensp
ENSP00000381034
resolver
ensp
ENSP00000463395
resolver
ensp
ENSP00000529966
resolver
ensp
ENSP00000529967
resolver
ensp
ENSP00000529968
resolver
ensp
ENSP00000529969
resolver
ensp
ENSP00000529970
resolver
ensp
ENSP00000529971
resolver
ensp
ENSP00000529972
resolver
ensp
ENSP00000529973
resolver
ensp
ENSP00000529974
resolver
ensp
ENSP00000529975
resolver
ensp
ENSP00000529976
resolver
ensp
ENSP00000587373
resolver
ensp
ENSP00000587374
resolver
ensp
ENSP00000587375
resolver
ensp
ENSP00000587376
resolver
ensp
ENSP00000625215
resolver
ensp
ENSP00000625216
resolver
ensp
ENSP00000625217
resolver
ensp
ENSP00000625218
resolver
ensp
ENSP00000625219
resolver
ensp
ENSP00000625220
resolver
ensp
ENSP00000625221
resolver
enst
ENST00000397942
resolver
enst
ENST00000582322
resolver
enst
ENST00000859907
resolver
enst
ENST00000859908
resolver
enst
ENST00000859909
resolver
enst
ENST00000859910
resolver
enst
ENST00000859911
resolver
enst
ENST00000859912
resolver
enst
ENST00000859913
resolver
enst
ENST00000859914
resolver
enst
ENST00000859915
resolver
enst
ENST00000859916
resolver
enst
ENST00000859917
resolver
enst
ENST00000917314
resolver
enst
ENST00000917315
resolver
enst
ENST00000917316
resolver
enst
ENST00000917317
resolver
enst
ENST00000955156
resolver
enst
ENST00000955157
resolver
enst
ENST00000955158
resolver
enst
ENST00000955159
resolver
enst
ENST00000955160
resolver
enst
ENST00000955161
resolver
enst
ENST00000955162
resolver
genesymbol
SOCS6
resolver
genesymbol_syn
CIS4
resolver
genesymbol_syn
SOCS4
resolver
hgnc
HGNC:16833
resolver
uniprot
Q8WUM3
resolver
uniprot_entry
SOCS6_HUMAN
resolver
uniprot_sec
Q8WUM3
resolver
amino_acid_sequence
MKKISLKTLRKSFNLNKSKEETDFMVVQQPSLASDFGKDDSLFGSCYGKDMASCDINGEDEKGGKNRSKSESLMGTLKRRLSAKQKSKGKAGTPSGSSADEDTFSSSSAPIVFKDVRAQRPIRSTSLRSHHYSPAPWPLRPTNSEETCIKMEVRVKALVHSSSPSPALNGVRKDFHDLQSETTCQEQANSLKSSASHNGDLHLHLDEHVPVVIGLMPQDYIQYTVPLDEGMYPLEGSRSYCLDSSSPMEVSAVPPQVGGRAFPEDESQVDQDLVVAPEIFVDQSVNGLLIGTTGVMLQSPRAGHDDVPPLSPLLPPMQNNQIQRNFSGLTGTEAHVAESMRCHLNFDPNSAPGVARVYDSVQSSGPMVVTSLTEELKKLAKQGWYWGPITRWEAEGKLANVPDGSFLVRDSSDDRYLLSLSFRSHGKTLHTRIEHSNGRFSFYEQPDVEGHTSIVDLIEHSIRDSENGAFCYSRSRLPGSATYPVRLTNPVSRFMQVRSLQYLCRFVIRQYTRIDLIQKLPLPNKMKDYLQEKHY
uniprot
proteins
function
FUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. {ECO:0000250, ECO:0000269|PubMed:21030588}.
uniprot
proteins
mass_dalton
59528
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15526160
uniprot
proteins
pubmed
21030588
uniprot
proteins
pubmed
9344848
uniprot
proteins
sequence_length
535
uniprot
proteins