Rnf182
entrez
498726
canonical
uniprot
D3ZBM4
canonical
ensembl
ENSRNOG00000018070
resolver
ensp
ENSRNOP00000024323
resolver
ensp
ENSRNOP00000089379
resolver
ensp
ENSRNOP00000092002
resolver
ensp
ENSRNOP00000098809
resolver
ensp
ENSRNOP00000099625
resolver
ensp
ENSRNOP00000102720
resolver
ensp
ENSRNOP00000102854
resolver
enst
ENSRNOT00000024323
resolver
enst
ENSRNOT00000095392
resolver
enst
ENSRNOT00000119567
resolver
enst
ENSRNOT00000136461
resolver
enst
ENSRNOT00000139599
resolver
enst
ENSRNOT00000146841
resolver
enst
ENSRNOT00000151878
resolver
genesymbol
Rnf182
resolver
uniprot_entry
RN182_RAT
resolver
amino_acid_sequence
MASQPPEEPAEFQVSDELECKICYNRYNLKQRKPKVLECCHRVCAKCLYKIIDFGDSPQGVIVCPFCRFETCLPDDEVSSLPDDNNILVNLTCGSKGKKCLPENPTELLLTPKRLASLVSPSHTSSNCLVITIMEVQRESSPSLSSTPVVEFYRPASFDSVTTVSHNWTVWNCTSLLFQTSIRVLVWLLGLLYFSSLPLGIYLLVSKKVTLGVVFVSLVPSSLVILMVYGFCQCVCHEFLDCMALPS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that mediates the ubiquitination of ATP6V0C and targets it to degradation via the ubiquitin-proteasome pathway. Also plays a role in the inhibition of TLR-triggered innate immune response by mediating 'Lys'-48-linked ubiquitination and subsequent degradation of NF-kappa-B component RELA. {ECO:0000250|UniProtKB:Q8N6D2}.
uniprot
proteins
mass_dalton
27546
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q8N6D2}.
uniprot
proteins
pubmed
30450663
uniprot
proteins
sequence_length
247
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q8N6D2}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8N6D2}. Cytoplasm {ECO:0000269|PubMed:30450663}.
uniprot
proteins
transmembrane_region
TRANSMEM 184..204; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 211..231; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins