NCOA7
entrez
135112
canonical
uniprot
Q8NI08
canonical
ensembl
ENSG00000111912
resolver
ensp
ENSP00000229634
resolver
ensp
ENSP00000357341
resolver
ensp
ENSP00000376269
resolver
ensp
ENSP00000398268
resolver
ensp
ENSP00000604315
resolver
ensp
ENSP00000604316
resolver
ensp
ENSP00000639260
resolver
ensp
ENSP00000639261
resolver
ensp
ENSP00000639262
resolver
ensp
ENSP00000679633
resolver
ensp
ENSP00000679634
resolver
genesymbol
NCOA7
resolver
genesymbol_syn
ERAP140
resolver
genesymbol_syn
ESNA1
resolver
hgnc
HGNC:21081
resolver
uniprot
A0A023IN41
resolver
uniprot
B2RNS2
resolver
uniprot
B3KXK4
resolver
uniprot
B7Z2C4
resolver
uniprot
B9EH71
resolver
uniprot
G8JL91
resolver
uniprot
H0Y5F6
resolver
uniprot
Q3LID6
resolver
uniprot
Q4G0V1
resolver
uniprot
Q5TF95
resolver
uniprot
Q6IPQ4
resolver
uniprot
Q6NE83
resolver
uniprot
Q86T89
resolver
uniprot
Q8N1W4
resolver
uniprot_entry
B3KXK4_HUMAN
resolver
uniprot_entry
NCOA7_HUMAN
resolver
uniprot_sec
A0A023IN41
resolver
uniprot_sec
B2RNS2
resolver
uniprot_sec
B7Z2C4
resolver
uniprot_sec
B9EH71
resolver
uniprot_sec
G8JL91
resolver
uniprot_sec
H0Y5F6
resolver
uniprot_sec
Q3LID6
resolver
uniprot_sec
Q4G0V1
resolver
uniprot_sec
Q5TF95
resolver
uniprot_sec
Q6IPQ4
resolver
uniprot_sec
Q6NE83
resolver
uniprot_sec
Q86T89
resolver
uniprot_sec
Q8N1W4
resolver
amino_acid_sequence
MDTKEEKKERKQSYFARLKKKKQAKQNAETASAVATRTHTGKEDNNTVVLEPDKCNIAVEEEYMTDEKKKRKSNQLKEIRRTELKRYYSIDDNQNKTHDKKEKKMVVQKPHGTMEYTAGNQDTLNSIALKFNITPNKLVELNKLFTHTIVPGQVLFVPDANSPSSTLRLSSSSPGATVSPSSSDAEYDKLPDADLARKALKPIERVLSSTSEEDEPGVVKFLKMNCRYFTDGKGVVGGVMIVTPNNIMFDPHKSDPLVIENGCEEYGLICPMEEVVSIALYNDISHMKIKDALPSDLPQDLCPLYRPGEWEDLASEKDINPFSKFKSINKEKRQQNGEKIMTSDSRPIVPLEKSTGHTPTKPSGSSVSEKLKKLDSSRETSHGSPTVTKLSKEPSDTSSAFESTAKENFLGEDDDFVDLEELSSQTGGGMHKKDTLKECLSLDPEERKKAESQINNSAVEMQVQSALAFLGTENDVELKGALDLETCEKQDIMPEVDKQSGSPESRVENTLNIHEDLDKVKLIEYYLTKNKEGPQVSENLQKTELSDGKSIEPGGIDITLSSSLSQAGDPITEGNKEPDKTWVKKGEPLPVKLNSSTEANVIKEALDSSLESTLDNSCQGAQMDNKSEVQLWLLKRIQVPIEDILPSKEEKSKTPPMFLCIKVGKPMRKSFATHTAAMVQQYGKRRKQPEYWFAVPRERVDHLYTFFVQWSPDVYGKDAKEQGFVVVEKEELNMIDNFFSEPTTKSWEIITVEEAKRRKSTCSYYEDEDEEVLPVLRPHSALLENMHIEQLARRLPARVQGYPWRLAYSTLEHGTSLKTLYRKSASLDSPVLLVIKDMDNQIFGAYATHPFKFSDHYYGTGETFLYTFSPHFKVFKWSGENSYFINGDISSLELGGGGGRFGLWLDADLYHGRSNSCSTFNNDILSKKEDFIVQDLEVWAFD
uniprot
proteins
function
FUNCTION: Transcriptional coactivator which enhances the transcriptional activities of several nuclear receptors including ESR1, THRB, PPARG and RARA (PubMed:11971969). Inhibits the activity of the vacuolar-type ATPase (V-ATPase) by inducing disassembly of the V-ATPase complex (PubMed:38593795). Protects the Golgi apparatus lumen from excess acidification by inhibiting V-ATPase ATP hydrolytic activity through interaction with V-ATPase catalytic subunit ATP6V1A, maintaining optimal conditions for glycosylation enzymes (By similarity). Required to stabilize V-ATPase V1 subunits ATP6V1B2 and ATP6V1A at membrane sites (By similarity). Involved in protection against oxidative damage (PubMed:17391516, PubMed:25330068). Involved in urine acidification (By similarity). {ECO:0000250|UniProtKB:Q6DFV7, ECO:0000269|PubMed:11971969, ECO:0000269|PubMed:17391516, ECO:0000269|PubMed:25330068, ECO:0000269|PubMed:38593795}.; FUNCTION: [Isoform 1]: Exhibits oxidation resistance activity (PubMed:25330068). Protects neuronal cells from oxidative stress with weaker neuroprotective activity than isoform 5 (By similarity). {ECO:0000250|UniProtKB:Q6DFV7, ECO:0000269|PubMed:25330068}.; FUNCTION: [Isoform 5]: Exhibits oxidation resistance activity (PubMed:25330068). Protects neuronal cells from oxidative stress with stronger neuroprotective activity than isoform 1 (By similarity). Inhibits endosome-mediated viral entry by inhibiting fusion of the viral and endosomal membranes and subsequent nuclear translocation of viral ribonucleoproteins (PubMed:30478388). Promotes increased cytoplasmic vesicular acidification, lysosomal protease activity and the degradation of endocytosed material (PubMed:30478388). {ECO:0000250|UniProtKB:Q6DFV7, ECO:0000269|PubMed:25330068, ECO:0000269|PubMed:30478388}.
uniprot
proteins
mass_dalton
106162
uniprot
proteins
mutagenesis
MUTAGEN 511..517; /note="LNIHEDL->ANAHEDA: No action on the E2-induced ESR1 binding."; /evidence="ECO:0000269|PubMed:11971969"; MUTAGEN 522..523; /note="LI->AA: Abolishes completely the E2-induced ESR1 binding."; /evidence="ECO:0000269|PubMed:11971969
uniprot
proteins
protein_family
OXR1 family
uniprot
proteins
pubmed
10395741
uniprot
proteins
pubmed
11971969
uniprot
proteins
pubmed
12880961
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17391516
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25330068
uniprot
proteins
pubmed
30478388
uniprot
proteins
pubmed
30670794
uniprot
proteins
pubmed
34341188
uniprot
proteins
pubmed
37199504
uniprot
proteins
pubmed
38593795
uniprot
proteins
sequence_length
942
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17391516}. Cytoplasm {ECO:0000269|PubMed:17391516}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q6DFV7}; Peripheral membrane protein {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q6DFV7}; Peripheral membrane protein {ECO:0000305}. Note=Predominantly nuclear following estradiol stimulation (PubMed:17391516). Localizes to the nucleus and cytoplasm in the absence of estradiol (PubMed:17391516). Recruited to the cis-Golgi network and trans-Golgi network membranes in a Rab-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q6DFV7, ECO:0000269|PubMed:17391516}.; SUBCELLULAR LOCATION: [Isoform 5]: Cytoplasm {ECO:0000269|PubMed:30478388}.
uniprot
proteins