DCAF13
entrez
25879
canonical
uniprot
Q9NV06
canonical
ensembl
ENSG00000164934
resolver
ensp
ENSP00000297579
resolver
ensp
ENSP00000477526
resolver
ensp
ENSP00000484962
resolver
enst
ENST00000297579
resolver
enst
ENST00000616836
resolver
genesymbol
DCAF13
resolver
genesymbol_syn
WDSOF1
resolver
hgnc
HGNC:24535
resolver
uniprot
A0A087WT20
resolver
uniprot
Q3MII9
resolver
uniprot
Q8NCH8
resolver
uniprot
Q8TC51
resolver
uniprot
Q96JY7
resolver
uniprot
Q9NZX3
resolver
uniprot_entry
A0A087WT20_HUMAN
resolver
uniprot_entry
DCA13_HUMAN
resolver
uniprot_sec
Q3MII9
resolver
uniprot_sec
Q8NCH8
resolver
uniprot_sec
Q8TC51
resolver
uniprot_sec
Q96JY7
resolver
uniprot_sec
Q9NZX3
resolver
amino_acid_sequence
MKVKMLSRNPDNYVRETKLDLQRVPRNYDPALHPFEVPREYIRALNATKLERVFAKPFLASLDGHRDGVNCLAKHPEKLATVLSGACDGEVRIWNLTQRNCIRTIQAHEGFVRGICTRFCGTSFFTVGDDKTVKQWKMDGPGYGDEEEPLHTILGKTVYTGIDHHWKEAVFATCGQQVDIWDEQRTNPICSMTWGFDSISSVKFNPIETFLLGSCASDRNIVLYDMRQATPLKKVILDMRTNTICWNPMEAFIFTAANEDYNLYTFDMRALDTPVMVHMDHVSAVLDVDYSPTGKEFVSASFDKSIRIFPVDKSRSREVYHTKRMQHVICVKWTSDSKYIMCGSDEMNIRLWKANASEKLGVLTSREKAAKDYNQKLKEKFQHYPHIKRIARHRHLPKSIYSQIQEQRIMKEARRRKEVNRIKHSKPGSVPLVSEKKKHVVAVVK
uniprot
proteins
function
FUNCTION: Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). Participates in the 18S rRNA processing in growing oocytes, being essential for oocyte nonsurrounded nucleolus (NSN) to surrounded nucleolus (SN) transition (PubMed:30283081). {ECO:0000269|PubMed:30283081, ECO:0000269|PubMed:34516797}.; FUNCTION: Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex that plays a key role in embryo preimplantation and is required for normal meiotic cycle progression in oocytes (PubMed:16949367, PubMed:30111536, PubMed:31492966). Acts as a maternal factor that regulates oocyte and zygotic chromatin tightness during maternal to zygotic transition (By similarity). Also involved in the transformation of the endometrium into the decidua, known as decidualization, providing a solid foundation for implantation of blastocysts (PubMed:35932979). Recognizes the histone methyltransferases SUV39H1 and SUV39H2 and directs them to polyubiquitination and proteasomal degradation, which facilitates the H3K9me3 removal and early zygotic gene expression, essential steps for progressive genome reprogramming and the establishment of pluripotency during preimplantation embryonic development (PubMed:30111536). Supports the spindle assembly and chromosome condensation during oocyte meiotic division by targeting the polyubiquitination and degradation of PTEN, a lipid phosphatase that inhibits PI3K pathway as well as oocyte growth and maturation (PubMed:31492966). Targets PMP22 for polyubiquitination and proteasomal degradation (By similarity). {ECO:0000250|UniProtKB:Q6PAC3, ECO:0000269|PubMed:16949367, ECO:0000269|PubMed:30111536, ECO:0000269|PubMed:31492966, ECO:0000269|PubMed:35932979}.
uniprot
proteins
mass_dalton
51402
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
WD repeat DCAF13/WDSOF1 family
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16949367
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24754225
uniprot
proteins
pubmed
28068668
uniprot
proteins
pubmed
30111536
uniprot
proteins
pubmed
30283081
uniprot
proteins
pubmed
31492966
uniprot
proteins
pubmed
34516797
uniprot
proteins
pubmed
35932979
uniprot
proteins
sequence_length
445
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:24754225, ECO:0000269|PubMed:30283081, ECO:0000269|PubMed:34516797}. Note=In the nucleolus, localizes predominantly in the granular component, but also detected in the fibrillar center and dense fibrillar component. {ECO:0000269|PubMed:24754225}.
uniprot
proteins