Ecsit
entrez
26940
canonical
uniprot
Q9QZH6
canonical
ensembl
ENSMUSG00000066839
resolver
ensp
ENSMUSP00000096537
resolver
ensp
ENSMUSP00000136247
resolver
ensp
ENSMUSP00000137424
resolver
ensp
ENSMUSP00000292284
resolver
ensp
ENSMUSP00000292287
resolver
ensp
ENSMUSP00000292289
resolver
ensp
ENSMUSP00000292296
resolver
enst
ENSMUST00000098937
resolver
enst
ENSMUST00000179422
resolver
enst
ENSMUST00000180180
resolver
genesymbol
Ecsit
resolver
genesymbol_syn
Sitpec
resolver
uniprot
A0A0R4J174
resolver
uniprot
Q91V53
resolver
uniprot_entry
A0A0R4J174_MOUSE
resolver
uniprot_entry
ECSIT_MOUSE
resolver
uniprot_sec
Q91V53
resolver
amino_acid_sequence
MSWVQVNLLVRSLSRGWGGLCRPALSGTPFAQVSLQALRGLHCSAATHKDEPWLVPRPPEPQRKPIKVPAMHEDLFKPSGNRERDKASFLNAVRSFGAHNVRKRGHVDFIYLALRKMPEFGVERDLSVYNLLLDVFPKEVFRPRNVIQRIFVHYPRQQECGVAVLEQMERHGVMPSAETEFLLIQIFGRKSYPMLKFLRMKLWFTRFKNINPYPVPRDLPQDPLDLAKLGLRHMEPDLSAKVTVYQMSLPSDSTGMEDPTQPHIVGIQSPDQQAALARHNPSRPVFVEGPFPLWLRNKCVYYHILRADLPPPEEEKVEEIPEEWELYYPQKLDLEYSRSGWDDYEFDVDEVTEGPVFAMCMAGAHDQATLIKWIQGLQETNPTLAQIPVVFRLARSTGELLTTSRLEGQSPPHSPPKGPEEDDETIQAEQQQGQS
uniprot
proteins
function
FUNCTION: Adapter protein that plays a role in different signaling pathways including TLRs and IL-1 pathways or innate antiviral induction signaling (PubMed:10465784). Plays a role in the activation of NF-kappa-B by forming a signal complex with TRAF6 and TAK1/MAP3K7 to activate TAK1/MAP3K7 leading to activation of IKKs. Once ubiquitinated, interacts with the dissociated RELA and NFKB1 proteins and translocates to the nucleus where it induces NF-kappa-B-dependent gene expression. Plays a role in innate antiviral immune response by bridging the pattern recognition receptors RIGI and MDA5/IFIT1 to the MAVS complex at the mitochondrion (By similarity). Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway (PubMed:14633973). Required for normal embryonic development (By similarity). {ECO:0000250|UniProtKB:Q9BQ95, ECO:0000269|PubMed:10465784, ECO:0000269|PubMed:14633973}.; FUNCTION: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I. {ECO:0000269|PubMed:29514094}.
uniprot
proteins
mass_dalton
49799
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated on Lys-372; leading to translocation in the nucleus together with RELA and NFKB1 and expression of NF-kappa-B-dependent genes. {ECO:0000250|UniProtKB:Q9BQ95}.
uniprot
proteins
protein_family
ECSIT family
uniprot
proteins
pubmed
10465784
uniprot
proteins
pubmed
14633973
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22588174
uniprot
proteins
pubmed
29514094
uniprot
proteins
sequence_length
435
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9BQ95}. Nucleus {ECO:0000250|UniProtKB:Q9BQ95}. Mitochondrion {ECO:0000250|UniProtKB:Q9BQ95}.
uniprot
proteins