TTC4
entrez
7268
canonical
uniprot
O95801
canonical
ensembl
ENSG00000243725
resolver
ensp
ENSP00000360329
resolver
ensp
ENSP00000547008
resolver
enst
ENST00000371281
resolver
genesymbol
TTC4
resolver
hgnc
HGNC:12394
resolver
uniprot
Q53Y95
resolver
uniprot
Q5TA96
resolver
uniprot
Q9H3I2
resolver
uniprot_entry
CNS1_HUMAN
resolver
uniprot_sec
Q53Y95
resolver
uniprot_sec
Q5TA96
resolver
uniprot_sec
Q9H3I2
resolver
amino_acid_sequence
MEQPGQDPTSDDVMDSFLEKFQSQPYRGGFHEDQWEKEFEKVPLFMSRAPSEIDPRENPDLACLQSIIFDEERSPEEQAKTYKDEGNDYFKEKDYKKAVISYTEGLKKKCADPDLNAVLYTNRAAAQYYLGNFRSALNDVTAARKLKPCHLKAIIRGALCHLELKHFAEAVNWCDEGLQIDAKEKKLLEMRAKADKLKRIEQRDVRKANLKEKKERNQNEALLQAIKARNIRLSEAACEDEDSASEGLGELFLDGLSTENPHGARLSLDGQGRLSWPVLFLYPEYAQSDFISAFHEDSRFIDHLMVMFGETPSWDLEQKYCPDNLEVYFEDEDRAELYRVPAKSTLLQVLQHQRYFVKALTPAFLVCVGSSPFCKNFLRGRKVYQIR
uniprot
proteins
function
FUNCTION: Co-chaperone that recruits molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1) to nascent polypeptides, facilitating their proper folding into functional proteins (PubMed:18320024). Client proteins include eukaryotic elongation factor eEF2, a key player in cellular translation. Stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity (By similarity). Promotes Sendai virus (SeV)-induced host cell innate immune responses (PubMed:29251827). {ECO:0000250|UniProtKB:P33313, ECO:0000269|PubMed:18320024, ECO:0000269|PubMed:29251827}.
uniprot
proteins
mass_dalton
44679
uniprot
proteins
mutagenesis
MUTAGEN 42; /note="V->D: No effect on interaction with HSPA8, HSP90AB1 and CDC6."; /evidence="ECO:0000269|PubMed:18320024"; MUTAGEN 67; /note="I->M: No effect on interaction with HSPA8, HSP90AB1 and CDC6."; /evidence="ECO:0000269|PubMed:18320024"; MUTAGEN 77; /note="E->A: No effect on interaction with HSPA8 and HSP90AB1. Loss of interaction with CDC6."; /evidence="ECO:0000269|PubMed:18320024"; MUTAGEN 152; /note="K->E: Loss of interaction with HSPA8."; /evidence="ECO:0000269|PubMed:18320024"; MUTAGEN 156; /note="R->E: Loss of interaction with HSPA8."; /evidence="ECO:0000269|PubMed:18320024"; MUTAGEN 217; /note="N->K: No effect on interaction with HSPA8 and HSP90AB1. Loss of interaction with CDC6."; /evidence="ECO:0000269|PubMed:18320024
uniprot
proteins
protein_family
TTC4 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18320024
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
29251827
uniprot
proteins
pubmed
30876805
uniprot
proteins
pubmed
9933562
uniprot
proteins
sequence_length
387
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18320024, ECO:0000269|PubMed:29251827}. Nucleus, nucleoplasm {ECO:0000269|PubMed:18320024}. Cytoplasm {ECO:0000269|PubMed:29251827}. Note=Predominantly nuclear in the G1 and S phases of cell cycle and is evenly distributed between the nucleus and cytoplasm in the G2 phase (By similarity). MSL1 can promote its nuclear localization (By similarity). {ECO:0000250|UniProtKB:Q8R3H9}.
uniprot
proteins