SYTL2
entrez
54843
canonical
uniprot
Q9HCH5
canonical
ensembl
ENSG00000137501
resolver
ensp
ENSP00000318803
resolver
ensp
ENSP00000352065
resolver
ensp
ENSP00000374608
resolver
ensp
ENSP00000374610
resolver
ensp
ENSP00000431701
resolver
ensp
ENSP00000432144
resolver
ensp
ENSP00000432996
resolver
ensp
ENSP00000434010
resolver
ensp
ENSP00000435855
resolver
ensp
ENSP00000489269
resolver
ensp
ENSP00000568018
resolver
ensp
ENSP00000568019
resolver
ensp
ENSP00000568020
resolver
ensp
ENSP00000568022
resolver
ensp
ENSP00000636619
resolver
ensp
ENSP00000662741
resolver
ensp
ENSP00000662742
resolver
ensp
ENSP00000662743
resolver
ensp
ENSP00000662744
resolver
ensp
ENSP00000662745
resolver
ensp
ENSP00000683863
resolver
ensp
ENSP00000683864
resolver
ensp
ENSP00000683865
resolver
ensp
ENSP00000683866
resolver
enst
ENST00000359152
resolver
enst
ENST00000634661
resolver
genesymbol
SYTL2
resolver
genesymbol_syn
KIAA1597
resolver
genesymbol_syn
SGA72M
resolver
genesymbol_syn
SLP2
resolver
genesymbol_syn
SLP2A
resolver
hgnc
HGNC:15585
resolver
uniprot
A0A0U1RR07
resolver
uniprot
A0A8J9FM55
resolver
uniprot
B3KRS3
resolver
uniprot
B4DJT5
resolver
uniprot
B4DKW3
resolver
uniprot
B4DQ26
resolver
uniprot
B7SA85
resolver
uniprot
B7ZLX6
resolver
uniprot
B7ZLX7
resolver
uniprot
Q2YDA7
resolver
uniprot
Q6TV07
resolver
uniprot
Q6ZN59
resolver
uniprot
Q6ZVC5
resolver
uniprot
Q8ND34
resolver
uniprot
Q96BJ2
resolver
uniprot
Q9H768
resolver
uniprot
Q9NXM1
resolver
uniprot_entry
A0A0U1RR07_HUMAN
resolver
uniprot_entry
A0A8J9FM55_HUMAN
resolver
uniprot_entry
SYTL2_HUMAN
resolver
uniprot_sec
B3KRS3
resolver
uniprot_sec
B4DJT5
resolver
uniprot_sec
B4DKW3
resolver
uniprot_sec
B4DQ26
resolver
uniprot_sec
B7SA85
resolver
uniprot_sec
B7ZLX6
resolver
uniprot_sec
B7ZLX7
resolver
uniprot_sec
Q2YDA7
resolver
uniprot_sec
Q6TV07
resolver
uniprot_sec
Q6ZN59
resolver
uniprot_sec
Q6ZVC5
resolver
uniprot_sec
Q8ND34
resolver
uniprot_sec
Q96BJ2
resolver
uniprot_sec
Q9H768
resolver
uniprot_sec
Q9NXM1
resolver
amino_acid_sequence
MIDLSFLTEEEQEAIMKVLQRDAALKRAEEERVRHLPEKIKDDQQLKNMSGQWFYEAKAKRHRDKIHGADIIRASMRKKRPQIAAEQSKDRENGAKESWVNNVNKDAFLPPELAGVVEEPEEDAAPASPSSSVVNPASSVIDMSQENTRKPNVSPEKRKNPFNSSKLPEGHSSQQTKNEQSKNGRTGLFQTSKEDELSESKEKSTVADTSIQKLEKSKQTLPGLSNGSQIKAPIPKARKMIYKSTDLNKDDNQSFPRQRTDSLKARGAPRGILKRNSSSSSTDSETLRYNHNFEPKSKIVSPGLTIHERISEKEHSLEDNSSPNSLEPLKHVRFSAVKDELPQSPGLIHGREVGEFSVLESDRLKNGMEDAGDTEEFQSDPKPSQYRKPSLFHQSTSSPYVSKSETHQPMTSGSFPINGLHSHSEVLTARPQSMENSPTINEPKDKSSELTRLESVLPRSPADELSHCVEPEPSQVPGGSSRDRQQGSEEEPSPVLKTLERSAARKMPSKSLEDISSDSSNQAKVDNQPEELVRSAEDVSTVPTQPDNPFSHPDKLKRMSKSVPAFLQDESDDRETDTASESSYQLSRHKKSPSSLTNLSSSSGMTSLSSVSGSVMSVYSGDFGNLEVKGNIQFAIEYVESLKELHVFVAQCKDLAAADVKKQRSDPYVKAYLLPDKGKMGKKKTLVVKKTLNPVYNEILRYKIEKQILKTQKLNLSIWHRDTFKRNSFLGEVELDLETWDWDNKQNKQLRWYPLKRKTAPVALEAENRGEMKLALQYVPEPVPGKKLPTTGEVHIWVKECLDLPLLRGSHLNSFVKCTILPDTSRKSRQKTRAVGKTTNPIFNHTMVYDGFRPEDLMEACVELTVWDHYKLTNQFLGGLRIGFGTGKSYGTEVDWMDSTSEEVALWEKMVNSPNTWIEATLPLRMLLIAKISK
uniprot
proteins
function
FUNCTION: Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive. {ECO:0000269|PubMed:17182843, ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}.
uniprot
proteins
mass_dalton
104930
uniprot
proteins
mutagenesis
MUTAGEN 11; /note="E->A: Abolishes interaction with RAB27A."; /evidence="ECO:0000269|PubMed:18812475"; MUTAGEN 32; /note="R->A: Abolishes interaction with RAB27A."; /evidence="ECO:0000269|PubMed:18812475
uniprot
proteins
post_translational_modification
PTM: Isoform 1 is highly susceptible to proteolytic degradation and is stabilized by the interaction with RAB27A.
uniprot
proteins
pubmed
10997877
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17182843
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18266782
uniprot
proteins
pubmed
18812475
uniprot
proteins
pubmed
18940603
uniprot
proteins
pubmed
35308027
uniprot
proteins
sequence_length
934
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:18812475}. Cell membrane {ECO:0000269|PubMed:18266782, ECO:0000269|PubMed:18812475}. Note=Recruited on vesicular structures in cytotoxic T-lymphocytes (CTL) by RAB27A. {ECO:0000269|PubMed:18812475}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000269|PubMed:17182843}. Note=In the pancreatic alpha cells distributed in both peripheral and anterior regions. Localizes on the glucagon granules in the cell periphery. {ECO:0000269|PubMed:17182843}.
uniprot
proteins