Dhps
entrez
330817
canonical
uniprot
Q3TXU5
canonical
ensembl
ENSMUSG00000060038
resolver
ensp
ENSMUSP00000077733
resolver
enst
ENSMUST00000078665
resolver
genesymbol
Dhps
resolver
uniprot
E9QM48
resolver
uniprot_entry
DHYS_MOUSE
resolver
uniprot_sec
E9QM48
resolver
amino_acid_sequence
MEGTPPGAAPSSALAAVLKHSSALPPESAQVQGYDFNRGVDYHALLDAYRTTGFQATNFGRAVQQVNAMIEKKLEPLAVDEDHHADLTQSRRPLTGCTIFLGYTSNLISSGIRETIRYLVQHNMVDVLVTTAGGVEEDLIKCLAPTYLGEFSLRGKELRESGINRIGNLLVPNDNYCKFEDWLMPILDQMVLEQNTEGVKWTPSKMISRLGKEINNPDSVYYWAHKNHIPVLSPALTDGSLGDMIFFHSYKNPGLVLDIVEDLRLINTQAIFAKRSGMIILGGGVVKHHIANANLMRNGADYAVYINTAQEFDGSDSGARPDEAVSWGKIRMDAQPVKVYADASLVFPLLVAETFAQKADAFRAEKNED
uniprot
proteins
ec_number
2.5.1.46
uniprot
proteins
function
FUNCTION: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. {ECO:0000250|UniProtKB:P49366}.
uniprot
proteins
mass_dalton
40642
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; eIF5A hypusination.
uniprot
proteins
protein_family
Deoxyhypusine synthase family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
369
uniprot
proteins