Slc16a10
entrez
170566
canonical
uniprot
Q91Y77
canonical
ensembl
ENSRNOG00000000588
resolver
ensembl
ENSRNOG00055000858
resolver
ensembl
ENSRNOG00060007559
resolver
ensembl
ENSRNOG00065008442
resolver
ensp
ENSRNOP00000000718
resolver
ensp
ENSRNOP00000075512
resolver
ensp
ENSRNOP00055001176
resolver
ensp
ENSRNOP00060009437
resolver
ensp
ENSRNOP00065009917
resolver
enst
ENSRNOT00000000718
resolver
enst
ENSRNOT00000087226
resolver
enst
ENSRNOT00055001450
resolver
enst
ENSRNOT00060012467
resolver
enst
ENSRNOT00065013389
resolver
genesymbol
Slc16a10
resolver
genesymbol_syn
Mct10
resolver
genesymbol_syn
Tat1
resolver
uniprot
A0A0G2KAT0
resolver
uniprot
G3V621
resolver
uniprot_entry
A0A0G2KAT0_RAT
resolver
uniprot_entry
MOT10_RAT
resolver
uniprot_sec
G3V621
resolver
amino_acid_sequence
MVPSQEEPAAAERETNEAQPPGPAPSDDAPLPVPGPSDVSDGSVEKVEVELTRSTGNQEPPEPPEGGWGWLVMLAAMWCNGSVFGIQNAYGVLFVSMLETFGAKDDDNMAFKAAWVGSLSMGMIFFCCPIVSVFTDMFGCRRTAVLGAAVGFVGLMSSSFVSSIEPLYFTYGVVFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTILLPLLLGNLTSTVGLCYTLRILCIFMFVLFLAGFTYRPLVPSSKEKESEDSRSSFFSRRKLSPPKKIFNFALFKETAYAVWAAGIPLALFGYFVPYVHLMNHVKERFKDVNNKEVLFMCIGVTSGVGRLLFGRIADYLPGVKKVYLQVLSFFFIGLTSMMIPLCSVFGALIALCLIMGLFDGCFISIMAPIAFELVGPQDASQAIGFLLGFMSIPMTVGPPVAGLLHDKLGSYDLAFYLAGIPPFIGGAVLCLIPWIHSKKQREISKNTGGEKMEKMLANQSSLLSSSSGIFKKESDSII
uniprot
proteins
function
FUNCTION: Sodium- and proton-independent thyroid hormones and aromatic acids transporter. Mediates both uptake and efflux of 3,5,3'-triiodothyronine (T3) and 3,5,3',5'-tetraiodothyronine (T4) with high affinity, suggesting a role in the homeostasis of thyroid hormone levels (By similarity). Responsible for low affinity bidirectional transport of the aromatic amino acids, such as phenylalanine, tyrosine, tryptophan and L-3,4-dihydroxyphenylalanine (L-dopa) (PubMed:11278508). Plays an important role in homeostasis of aromatic amino acids (By similarity). {ECO:0000250|UniProtKB:Q3U9N9, ECO:0000250|UniProtKB:Q8TF71, ECO:0000269|PubMed:11278508}.
uniprot
proteins
mass_dalton
55678
uniprot
proteins
post_translational_modification
PTM: Not N-glycosylated. {ECO:0000250}.
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Monocarboxylate porter (TC 2.A.1.13) family
uniprot
proteins
pubmed
11278508
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
514
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8TF71}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000269|PubMed:11278508}; Multi-pass membrane protein {ECO:0000255}. Note=In the epithelial cells is detected in the basolateral membrane but not in the apical membrane.
uniprot
proteins
transmembrane_region
TRANSMEM 66..86; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 114..134; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 144..164; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 171..191; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 200..220; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 228..248; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 291..311; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 329..349; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 351..371; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 396..416; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 419..439; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 451..471; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins