MMS22L
entrez
253714
canonical
uniprot
Q6ZRQ5
canonical
ensembl
ENSG00000146263
resolver
ensp
ENSP00000275053
resolver
ensp
ENSP00000358254
resolver
ensp
ENSP00000508046
resolver
ensp
ENSP00000599411
resolver
ensp
ENSP00000599412
resolver
ensp
ENSP00000782476
resolver
enst
ENST00000275053
resolver
enst
ENST00000369251
resolver
enst
ENST00000683635
resolver
enst
ENST00000929352
resolver
enst
ENST00000929353
resolver
genesymbol
MMS22L
resolver
genesymbol_syn
C6orf167
resolver
hgnc
HGNC:21475
resolver
uniprot
D6R9Y8
resolver
uniprot
D6RBQ4
resolver
uniprot
E1P529
resolver
uniprot
E2QRD4
resolver
uniprot
Q5THT2
resolver
uniprot
Q68CQ6
resolver
uniprot
Q68D32
resolver
uniprot_entry
E2QRD4_HUMAN
resolver
uniprot_entry
MMS22_HUMAN
resolver
uniprot_sec
D6R9Y8
resolver
uniprot_sec
D6RBQ4
resolver
uniprot_sec
E1P529
resolver
uniprot_sec
Q5THT2
resolver
uniprot_sec
Q68CQ6
resolver
uniprot_sec
Q68D32
resolver
amino_acid_sequence
MENCSAASTFLTDSLELELGTEWCKPPYFSCAVDNRGGGKHFSGESYLCSGALKRLILNLDPLPTNFEEDTLEIFGIQWVTETALVNSSRELFHLFRQQLYNLETLLQSSCDFGKVSTLHCKADNIRQQCVLFLHYVKVFIFRYLKVQNAESHVPVHPYEALEAQLPSVLIDELHGLLLYIGHLSELPSVNIGAFVNQNQIKLFPPSWHLLHLHLDIHWLVLEILYMLGEKLKQVVYGHQFMNLASDNLTNISLFEEHCETLLCDLISLSLNRYDKVRSSESLMSDQCPCLCIKELWVLLIHLLDHRSKWFVSESFWNWLNKLLKTLLEKSSDRRRSSMPVIQSRDPLGFSWWIITHVASFYKFDRHGVPDEMRKVESNWNFVEELLKKSISVQGVILEEQLRMYLHCCLTLCDFWEPNIAIVTILWEYYSKNLNSSFSISWLPFKGLANTMKSPLSMLEMVKTCCCDKQDQELYKSSSSYTIFLCILAKVVKKAMKSNGPHPWKQVKGRIYSKFHQKRMEELTEVGLQNFFSLFLLLAAVAEVEDVASHVLDLLNFLKPAFVTSQRALIWKGHMAFLLMYAQKNLDIGVLAEKFSCAFREKAKEFLVSKNEEMVQRQTIWTLLSIYIDGVQEVFETSYCLYPSHEKLLNDGFSMLLRACRESELRTVLSFLQAVLARIRSMHQQLCQELQRDNVDLFVQSSLSAKERHLAAVASALWRHFFSFLKSQRMSQVVPFSQLADAAADFTLLAMDMPSTAPSDFQPQPVISIIQLFGWDDIICPQVVARYLSHVLQNSTLCEALSHSGYVSFQALTVRSWIRCVLQMYIKNLSGPDDLLIDKNLEEAVEKEYMKQLVKLTRLLFNLSEVKSIFSKAQVEYLSISEDPKKALVRFFEAVGVTYGNVQTLSDKSAMVTKSLEYLGEVLKYIKPYLGKKVFSAGLQLTYGMMGILVKSWAQIFATSKAQKLLFRIIDCLLLPHAVLQQEKELPAPMLSAIQKSLPLYLQGMCIVCCQSQNPNAYLNQLLGNVIEQYIGRFLPASPYVSDLGQHPVLLALRNTATIPPISSLKKCIVQVIRKSYLEYKGSSPPPRLASILAFILQLFKETNTDIYEVELLLPGILKCLVLVSEPQVKRLATENLQYMVKACQVGSEEEPSSQLTSVFRQFIQDYGMRYYYQVYSILETVATLDQQVVIHLISTLTQSLKDSEQKWGLGRNIAQREAYSKLLSHLGQMGQDEMQRLENDNT
uniprot
proteins
function
FUNCTION: Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks (PubMed:21055983, PubMed:21055984, PubMed:21055985, PubMed:21113133, PubMed:26527279, PubMed:27338793, PubMed:29478807). The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication (PubMed:21055983, PubMed:21055984, PubMed:21055985, PubMed:27797818). It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs (PubMed:21055983, PubMed:21055984, PubMed:21055985, PubMed:29478807). Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination (PubMed:27797818, PubMed:29478807). Within the complex, MMS22L acts by binding ssDNA (PubMed:27797818). {ECO:0000269|PubMed:21055983, ECO:0000269|PubMed:21055984, ECO:0000269|PubMed:21055985, ECO:0000269|PubMed:21113133, ECO:0000269|PubMed:26527279, ECO:0000269|PubMed:27338793, ECO:0000269|PubMed:27797818, ECO:0000269|PubMed:29478807}.
uniprot
proteins
mass_dalton
142321
uniprot
proteins
mutagenesis
MUTAGEN 29..32; /note="FSCA->ASCD: Does not affect interaction with RAD51."; /evidence="ECO:0000269|PubMed:27797818"; MUTAGEN 595..598; /note="FSCA->ASCD: Does not affect interaction with RAD51."; /evidence="ECO:0000269|PubMed:27797818"; MUTAGEN 1034..1037; /note="FLPA->ALPD: Abolished interaction with RAD51."; /evidence="ECO:0000269|PubMed:27797818"; MUTAGEN 1034; /note="F->A: Abolished interaction with RAD51."; /evidence="ECO:0000269|PubMed:27797818
uniprot
proteins
post_translational_modification
PTM: Degraded by the ubiquitin-proteasome system upon replication stress. {ECO:0000269|PubMed:21113133}.
uniprot
proteins
protein_family
MMS22 family
uniprot
proteins
protein_family
MMS22L subfamily
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21055983
uniprot
proteins
pubmed
21055984
uniprot
proteins
pubmed
21055985
uniprot
proteins
pubmed
21113133
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
26527279
uniprot
proteins
pubmed
27338793
uniprot
proteins
pubmed
27797818
uniprot
proteins
pubmed
29478807
uniprot
proteins
sequence_length
1243
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21055983, ECO:0000269|PubMed:21055984, ECO:0000269|PubMed:21113133}. Chromosome {ECO:0000269|PubMed:21055983, ECO:0000269|PubMed:21055984, ECO:0000269|PubMed:21113133, ECO:0000269|PubMed:27338793, ECO:0000269|PubMed:27797818}. Note=Localizes to DNA damage sites, accumulates at stressed replication forks (PubMed:21055983, PubMed:21055984, PubMed:27797818). Recruited to stalled or collapsed replication forks; directly binds replication protein A complex (RPA/RP-A)-coated single-stranded DNA (ssDNA) (PubMed:27797818). {ECO:0000269|PubMed:21055983, ECO:0000269|PubMed:21055984, ECO:0000269|PubMed:27797818}.
uniprot
proteins