CD74
entrez
972
canonical
uniprot
P04233
canonical
ensembl
ENSG00000019582
resolver
ensp
ENSP00000009530
resolver
ensp
ENSP00000230685
resolver
ensp
ENSP00000367026
resolver
ensp
ENSP00000551270
resolver
ensp
ENSP00000657973
resolver
genesymbol
CD74
resolver
genesymbol_syn
DHLAG
resolver
hgnc
HGNC:1697
resolver
uniprot
A8K7R1
resolver
uniprot
B4DNE8
resolver
uniprot
D3DQG3
resolver
uniprot
D3DQG4
resolver
uniprot
Q14597
resolver
uniprot
Q29832
resolver
uniprot
Q5U0J8
resolver
uniprot
Q8SNA0
resolver
uniprot
Q8WLP6
resolver
uniprot_entry
HG2A_HUMAN
resolver
uniprot_sec
A8K7R1
resolver
uniprot_sec
B4DNE8
resolver
uniprot_sec
D3DQG3
resolver
uniprot_sec
D3DQG4
resolver
uniprot_sec
Q14597
resolver
uniprot_sec
Q29832
resolver
uniprot_sec
Q5U0J8
resolver
uniprot_sec
Q8SNA0
resolver
uniprot_sec
Q8WLP6
resolver
amino_acid_sequence
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLLLAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKPPKPVSKMRMATPLLMQALPMGALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKVFESWMHHWLLFEMSRHSLEQKPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLPLQCYGSIGYCWCVFPNGTEVPNTRSRGHHNCSESLELEDPSSGLGVTKQDLGPVPM
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving CD74 is found in a non-small cell lung tumor. Results in the formation of a CD74-ROS1 chimeric protein. {ECO:0000269|PubMed:12661006}.
uniprot
proteins
function
FUNCTION: Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF.; FUNCTION: [Class-II-associated invariant chain peptide]: Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome. {ECO:0000269|PubMed:1448172}.; FUNCTION: [Isoform p41]: Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2 (PubMed:32855215). Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform (PubMed:32855215). {ECO:0000250|UniProtKB:P04441, ECO:0000269|PubMed:32855215}.
uniprot
proteins
mass_dalton
33516
uniprot
proteins
mutagenesis
MUTAGEN 225..226; /note="PG->RR,DD: Decreases inhibition of Ebola virus infection."; /evidence="ECO:0000269|PubMed:32855215"; MUTAGEN 225..226; /note="PG->TT: No effect on inhibition of Ebola virus infection."; /evidence="ECO:0000269|PubMed:32855215
uniprot
proteins
post_translational_modification
PTM: O-glycosylated with core 1 or possibly core 8 glycans (PubMed:22171320, PubMed:23234360). Contains chondroitin sulfate (PubMed:25326458). {ECO:0000269|PubMed:22171320, ECO:0000269|PubMed:23234360, ECO:0000269|PubMed:25326458}.
uniprot
proteins
pubmed
10022822
uniprot
proteins
pubmed
12661006
uniprot
proteins
pubmed
12782713
uniprot
proteins
pubmed
1448172
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19092054
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22171320
uniprot
proteins
pubmed
23234360
uniprot
proteins
pubmed
25326458
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
3001652
uniprot
proteins
pubmed
3104027
uniprot
proteins
pubmed
32337544
uniprot
proteins
pubmed
32855215
uniprot
proteins
pubmed
3459184
uniprot
proteins
pubmed
36213313
uniprot
proteins
pubmed
37453717
uniprot
proteins
pubmed
6324166
uniprot
proteins
pubmed
6586420
uniprot
proteins
pubmed
7477400
uniprot
proteins
pubmed
9843486
uniprot
proteins
sequence_length
296
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Endoplasmic reticulum membrane. Golgi apparatus, trans-Golgi network. Endosome. Lysosome. Secreted {ECO:0000269|PubMed:25326458, ECO:0000269|PubMed:36213313, ECO:0000269|PubMed:37453717}. Note=Transits through a number of intracellular compartments in the endocytic pathway. It can either undergo proteolysis or reach the cell membrane.; SUBCELLULAR LOCATION: [Isoform p41]: Late endosome {ECO:0000250|UniProtKB:P04441}. Lysosome {ECO:0000250|UniProtKB:P04441}.
uniprot
proteins
transmembrane_region
TRANSMEM 47..72; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins