Dcaf12
entrez
68970
canonical
uniprot
Q8BGZ3
canonical
ensembl
ENSMUSG00000028436
resolver
ensp
ENSMUSP00000030145
resolver
ensp
ENSMUSP00000209032
resolver
enst
ENSMUST00000030145
resolver
genesymbol
Dcaf12
resolver
genesymbol_syn
Kiaa1892
resolver
genesymbol_syn
Wdr40a
resolver
uniprot
Q69Z77
resolver
uniprot
Q8BN60
resolver
uniprot
Q8C1Y4
resolver
uniprot
Q9DB95
resolver
uniprot_entry
DCA12_MOUSE
resolver
uniprot_sec
Q69Z77
resolver
uniprot_sec
Q8BN60
resolver
uniprot_sec
Q8C1Y4
resolver
uniprot_sec
Q9DB95
resolver
amino_acid_sequence
MARKAVSRKRKASASPGAGSDAQGPQFGWDHSLHKRKRLPPVKRSLVYYLKNREVRLQNETSYSRLLHGYAAQQLPSLLKEREFHLGTLNKVFASQWLNHRQVVCGTKCNTLFVVDVQTGQITKIPILKDREPGGVTQQGCGIHAIELNPSRTLLATGGDNPNSLAIYRLPTLDPVCVGDDGHKDWIFSIAWINDTMAVSGSRDGSMGLWEVTDDVLTKSDARHNVSPVPVYAHITHKALKDIPKEDTNPDNCKVRALAFNNKNKELGAVSLDGYFHLWKAENTLSKLLSTKLPYCRENVCLAYGSEWSVYAVGSQAHVSFLDPRQPSYNVKSVCSRERGSGIRSVSFYEHIITVGTGQGSLLFYDIRAQRFLEERLSACYGSKPRLAGENLKLTTGRGWLNHDETWRNYFSDIDFFPNAVYTHCYDSSGTKLFVAGGPLPSGLHGNYAGLWS
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation. The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed:34065512). The DCX(DCAF12) complex specifically recognizes proteins with a diglutamate (Glu-Glu) at the C-terminus, such as MAGEA3, MAGEA6 and CCT5, leading to their ubiquitination and degradation. Ubiquitination of MAGEA3, MAGEA6 by DCX(DCAF12) complex is required for starvation-induced autophagy (By similarity). Also directly recognizes the C-terminal glutamate-leucine (Glu-Leu) degron as an alternative degron in proteins such as MOV10, leading to their ubiquitination and degradation. Controls the protein level of MOV10 during spermatogenesis and in T cells, especially after their activation (PubMed:34065512). {ECO:0000250|UniProtKB:Q5T6F0, ECO:0000269|PubMed:34065512}.
uniprot
proteins
mass_dalton
50459
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q5T6F0}.
uniprot
proteins
protein_family
WD repeat DCAF12 family
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
34065512
uniprot
proteins
sequence_length
453
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5T6F0}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q5T6F0}. Nucleus {ECO:0000250|UniProtKB:Q5T6F0}.
uniprot
proteins