Arrdc1
entrez
215705
canonical
uniprot
Q99KN1
canonical
ensembl
ENSMUSG00000026972
resolver
ensp
ENSMUSP00000028349
resolver
ensp
ENSMUSP00000099999
resolver
ensp
ENSMUSP00000237192
resolver
ensp
ENSMUSP00000237197
resolver
ensp
ENSMUSP00000237202
resolver
ensp
ENSMUSP00000237204
resolver
genesymbol
Arrdc1
resolver
uniprot
A2AIS7
resolver
uniprot
A2AIS8
resolver
uniprot
Q3TDT6
resolver
uniprot
Q8VEG7
resolver
uniprot_entry
ARRD1_MOUSE
resolver
uniprot_sec
A2AIS7
resolver
uniprot_sec
A2AIS8
resolver
uniprot_sec
Q3TDT6
resolver
uniprot_sec
Q8VEG7
resolver
amino_acid_sequence
MGRVQLFEIRLSQGRVVYGPGEPLAGTVHLRLGAPLPFRAIRVTCMGSCGVSTKANDGAWVVEESYFNSSLSLADKGSLPAGEHNFPFQFLLPATAPTSFEGPFGKIVHQVRASIDTPRFSKDHKCSLVFYILSPLNLNSIPDIEQPNVASTTKKFSYKLVKTGNVVLTASTDLRGYVVGQVLRLQADIENQSGKDTSPVVASLLQKVSYKAKRWIYDVRTIAEVEGTGVKAWRRAQWQEQILVPALPQSALPGCSLIHIDYYLQVSMKAPEATVTLPLFVGNIAVNQTPLSPCPGRESSPGTLSLVVPSAPPQEEAEAVASGPHFSDPVSLSTKSHSQQQPLSAPLGSVSVTTTEPWVQVGSPARHSLHPPLCISIGATVPYFAEGSAGPVPTTSALILPPEYSSWGYPYEAPPSYEQSCGAAGTDLGLIPGS
uniprot
proteins
function
FUNCTION: Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed:23886940, PubMed:27462458). Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles (PubMed:27462458). More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles (By similarity). By participating to the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway (PubMed:23886940). {ECO:0000250|UniProtKB:Q8N5I2, ECO:0000269|PubMed:23886940, ECO:0000269|PubMed:27462458}.
uniprot
proteins
mass_dalton
46330
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Ubiquitination by WWP2; promotes localization to extracellular microvesicles. Ubiquitinated by WWP1. {ECO:0000250|UniProtKB:Q8N5I2}.
uniprot
proteins
protein_family
Arrestin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23886940
uniprot
proteins
pubmed
27462458
uniprot
proteins
sequence_length
434
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8N5I2}. Note=Also found in extracellular vesicles different from exosomes. {ECO:0000250|UniProtKB:Q8N5I2}.
uniprot
proteins