Rhbdd1
entrez
316557
canonical
uniprot
Q4V8F3
canonical
ensembl
ENSRNOG00000054963
resolver
ensembl
ENSRNOG00055007057
resolver
ensembl
ENSRNOG00060006773
resolver
ensembl
ENSRNOG00065021404
resolver
ensp
ENSRNOP00000073441
resolver
ensp
ENSRNOP00000082541
resolver
ensp
ENSRNOP00055009189
resolver
ensp
ENSRNOP00060008301
resolver
ensp
ENSRNOP00065029340
resolver
enst
ENSRNOT00000107081
resolver
enst
ENSRNOT00055011659
resolver
enst
ENSRNOT00060011111
resolver
enst
ENSRNOT00065036414
resolver
genesymbol
Rhbdd1
resolver
genesymbol_syn
Rhbdl4
resolver
uniprot_entry
RHBL4_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by aprotinin. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MQRRTRGIDTGLLLLLSQVFHIGINNIPPVTLATLAVNVWFFLNPWKPLYHSCISVEKCYQQNDWQRLLLSPVHHGDDWHLYFNMVSMLWKGVKLEKRLGSRWFAYIIATFSLLTGVVYLLLQFASAELMNQPDFKRNCAVGFSGVLFALKVLSNHYCPGGFVNILGFPVPNRFACWAELAAIHFCTPGTSFAGHLAGILVGLMYTQGPLKKIMDACAGIFISNAGSSGQQYHFNNAGPSGYQNRYTDGRPVNYEATYRNYDIYTAGLSEEEQLERALRASIWDRGNTRNGPIPYGFRLPPEEEMRRQRLHRFDGQ
uniprot
proteins
ec_number
3.4.21.105
uniprot
proteins
function
FUNCTION: Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Functions in BIK, MPZ, PKD1, PTCRA, RHO, STEAP3 and TRAC processing. Involved in the regulation of exosomal secretion; inhibits the TSAP6-mediated secretion pathway. Involved in the regulation of apoptosis; modulates BIK-mediated apoptotic activity. Also plays a role in the regulation of spermatogenesis; inhibits apoptotic activity in spermatogonia (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
35879
uniprot
proteins
protein_family
Peptidase S54 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19358743
uniprot
proteins
sequence_length
316
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8TEB9}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q8TEB9}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 104..124; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 138..154; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 183..203; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins