HACD3
entrez
51495
canonical
uniprot
Q9P035
canonical
ensembl
ENSG00000074696
resolver
ensp
ENSP00000261875
resolver
ensp
ENSP00000454873
resolver
ensp
ENSP00000455587
resolver
ensp
ENSP00000455686
resolver
ensp
ENSP00000456300
resolver
enst
ENST00000562901
resolver
enst
ENST00000566074
resolver
enst
ENST00000566511
resolver
enst
ENST00000569894
resolver
genesymbol
HACD3
resolver
genesymbol_syn
BIND1
resolver
genesymbol_syn
PTPLAD1
resolver
hgnc
HGNC:24175
resolver
uniprot
A0PJA1
resolver
uniprot
B4DRF4
resolver
uniprot
H3BRL8
resolver
uniprot
Q280Z3
resolver
uniprot
Q6PD63
resolver
uniprot
Q8IUI5
resolver
uniprot
Q8NC86
resolver
uniprot
Q8NCB1
resolver
uniprot
Q96T12
resolver
uniprot
Q9NQA7
resolver
uniprot_entry
H3BRL8_HUMAN
resolver
uniprot_entry
HACD3_HUMAN
resolver
uniprot_sec
A0PJA1
resolver
uniprot_sec
B4DRF4
resolver
uniprot_sec
Q280Z3
resolver
uniprot_sec
Q6PD63
resolver
uniprot_sec
Q8IUI5
resolver
uniprot_sec
Q8NC86
resolver
uniprot_sec
Q8NCB1
resolver
uniprot_sec
Q96T12
resolver
uniprot_sec
Q9NQA7
resolver
amino_acid_sequence
MENQVLTPHVYWAQRHRELYLRVELSDVQNPAISITENVLHFKAQGHGAKGDNVYEFHLEFLDLVKPEPVYKLTQRQVNITVQKKVSQWWERLTKQEKRPLFLAPDFDRWLDESDAEMELRAKEEERLNKLRLESEGSPETLTNLRKGYLFMYNLVQFLGFSWIFVNLTVRFCILGKESFYDTFHTVADMMYFCQMLAVVETINAAIGVTTSPVLPSLIQLLGRNFILFIIFGTMEEMQNKAVVFFVFYLWSAIEIFRYSFYMLTCIDMDWKVLTWLRYTLWIPLYPLGCLAEAVSVIQSIPIFNETGRFSFTLPYPVKIKVRFSFFLQIYLIMIFLGLYINFRHLYKQRRRRYGQKKKKIH
uniprot
proteins
ec_number
4.2.1.134
uniprot
proteins
function
FUNCTION: Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May be involved in Rac1-signaling pathways leading to the modulation of gene expression. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). {ECO:0000269|PubMed:10747961, ECO:0000269|PubMed:18554506, ECO:0000269|PubMed:25687571}.
uniprot
proteins
mass_dalton
43160
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; fatty acid biosynthesis. {ECO:0000269|PubMed:18554506}.
uniprot
proteins
protein_family
Very long-chain fatty acids dehydratase HACD family
uniprot
proteins
pubmed
10747961
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16516406
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
16638134
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18554506
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25687571
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
362
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:18554506}; Multi-pass membrane protein {ECO:0000269|PubMed:18554506}.
uniprot
proteins
transmembrane_region
TRANSMEM 150..170; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 186..207; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 218..235; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 242..256; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 280..298; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 323..343; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins