Ifnb1
entrez
15977
canonical
uniprot
P01575
canonical
ensembl
ENSMUSG00000048806
resolver
ensp
ENSMUSP00000056720
resolver
enst
ENSMUST00000055671
resolver
genesymbol
Ifnb1
resolver
genesymbol_syn
Ifb
resolver
genesymbol_syn
Ifnb
resolver
uniprot
Q0VE17
resolver
uniprot_entry
IFNB_MOUSE
resolver
uniprot_entry
Q0VE17_MOUSE
resolver
amino_acid_sequence
MNNRWILHAAFLLCFSTTALSINYKQLQLQERTNIRKCQELLEQLNGKINLTYRADFKIPMEMTEKMQKSYTAFAIQEMLQNVFLVFRNNFSSTGWNETIVVRLLDELHQQTVFLKTVLEEKQEERLTWEMSSTALHLKSYYWRVQRYLKLMKYNSYAWMVVRAEIFRNFLIIRRLTRNFQN
uniprot
proteins
function
FUNCTION: Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli (PubMed:10708458, PubMed:23872679). Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins (By similarity). Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways (PubMed:23872679). Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor (PubMed:10708458, PubMed:14597717). Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss (PubMed:26451483). IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth (PubMed:14597717). {ECO:0000250|UniProtKB:P01574, ECO:0000269|PubMed:10708458, ECO:0000269|PubMed:14597717, ECO:0000269|PubMed:23872679, ECO:0000269|PubMed:26451483}.
uniprot
proteins
mass_dalton
22127
uniprot
proteins
post_translational_modification
PTM: This beta interferon does not have a disulfide bond. {ECO:0000269|PubMed:1505514}.
uniprot
proteins
protein_family
Type-I (or alpha/beta) interferon family
uniprot
proteins
pubmed
10708458
uniprot
proteins
pubmed
12707359
uniprot
proteins
pubmed
14597717
uniprot
proteins
pubmed
1505514
uniprot
proteins
pubmed
23872679
uniprot
proteins
pubmed
26451483
uniprot
proteins
pubmed
2726460
uniprot
proteins
pubmed
3221389
uniprot
proteins
pubmed
3360010
uniprot
proteins
pubmed
6688252
uniprot
proteins
pubmed
7473712
uniprot
proteins
sequence_length
182
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01574}.
uniprot
proteins