Gmeb1
entrez
56809
canonical
uniprot
Q9JL60
canonical
ensembl
ENSMUSG00000028901
resolver
ensp
ENSMUSP00000030733
resolver
ensp
ENSMUSP00000101584
resolver
ensp
ENSMUSP00000101585
resolver
ensp
ENSMUSP00000131331
resolver
ensp
ENSMUSP00000216361
resolver
ensp
ENSMUSP00000216365
resolver
ensp
ENSMUSP00000216374
resolver
enst
ENSMUST00000030733
resolver
enst
ENSMUST00000105964
resolver
enst
ENSMUST00000105965
resolver
enst
ENSMUST00000168553
resolver
genesymbol
Gmeb1
resolver
uniprot
Q3UYV4
resolver
uniprot
Q80Y88
resolver
uniprot_entry
GMEB1_MOUSE
resolver
uniprot_entry
Q3UYV4_MOUSE
resolver
uniprot_sec
Q80Y88
resolver
amino_acid_sequence
MANAEVSVPVGDVVVVPTEGNEGENPEDTKTQVILQLQPVQQGIYEAGSENSAAVVAVETHSIHKIEEGIDASSIEGNEDMEIAYPITCGESKAVLLWKKFVCPGINVKCVKFNDQLISPKHFVHLAGKSTLKDWKRAIRLGGIMLRKMMDSGQIDFYQHDKVCSNTCRSTKFDLLISSARAPVPGQQTSVVQTPTSADGNITQIAISEESMEEAGLEWNSALTAAVTMATEEGIKKESEEISEDTLMFWKGIADVGLMEEVVCNIQKEMEELLRGVQQRLIQAPFQVTDAAVLNNVANTFGLMDAVKRVLDNRRKQVEQGEEQFLYTLADLERQLEEQKKQAQDPRLKSQTVQNVVLMPVSTPKPPKRPRLQRPASTTVLSPSPVQQPQFTVISPITITPVGQSFSMGNIPVATLSQGSSPVTVHTLPSGPQLFRYATVVSSAKSNSPDTVTIHPSSSLALLSSTSMQDGSSLGNMATMVSPMELVAMESGLTSAIQAVESTSEDGQTIIEIDPAPDSEADDTEGKAVILETGLRTEEKVVAEMEEHQHQVHNVEIVVLED
uniprot
proteins
function
FUNCTION: Acts as a DNA-binding transcriptional regulator involved in modulating the expression of genes responsive to glucocorticoid signaling. Specifically binds AT-rich DNA motifs known as glucocorticoid modulatory elements (GMEs), repressing or enhancing transcription depending on cellular context. Forms heterodimeric complexes with GMEB2, which enhances its DNA-binding specificity and transcriptional activity. This complex plays a critical role in the repression of glucocorticoid receptor (GR/NR3C1) transcriptional activity, acting as a negative modulator of glucocorticoid signaling (By similarity). Regulates dopamine-enriched midbrain genes, including tyrosine hydroxylase/TH and the dopamine transporter SLC6A3, essential for dopamine signaling (PubMed:31175277). Also binds the transferrin receptor promoter. In the cytoplasm, inhibits caspase activation and neuronal apoptosis by stabilizing CFLARL and blocking pro-caspase 8 activation (By similarity). {ECO:0000250|UniProtKB:Q9Y692, ECO:0000269|PubMed:31175277}.
uniprot
proteins
mass_dalton
61058
uniprot
proteins
pubmed
10692587
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31175277
uniprot
proteins
sequence_length
562
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:31175277}. Cytoplasm. Note=May be also cytoplasmic. {ECO:0000269|PubMed:31175277}.
uniprot
proteins