Slc35b1
entrez
287642
canonical
uniprot
Q6V7K3
canonical
ensembl
ENSRNOG00000004510
resolver
ensembl
ENSRNOG00055032292
resolver
ensembl
ENSRNOG00060023309
resolver
ensembl
ENSRNOG00065018356
resolver
ensp
ENSRNOP00000006179
resolver
ensp
ENSRNOP00055045940
resolver
ensp
ENSRNOP00060033332
resolver
ensp
ENSRNOP00065024508
resolver
enst
ENSRNOT00055055755
resolver
enst
ENSRNOT00060040360
resolver
enst
ENSRNOT00065030797
resolver
genesymbol
Slc35b1
resolver
uniprot
P70639
resolver
uniprot_entry
S35B1_RAT
resolver
uniprot_sec
P70639
resolver
amino_acid_sequence
MAASRSLVPDRLRLPLCFLGVFVCYFYYGILQEKITRGKYGEGPKQETFTFALTLVFIQCVINAMFAKILIQFFDTARVDRTRTWLYAACSVSYVGAMVSSNSALQFVNYPTQVLGKSCKPIPVMLLGVTLLKKKYPLAKYLCVLLIVAGVALFMYKPKKVVGIEEHTVGFGELLLLLSLTLDGLTGVSQDHMRAHYQTGSNHMMLNINLWSTVLLGAGILFTGELWEFLSFAERYPTIIYNILLFGLTSALGQSFIFMTVVYFGPLTCSIITTTRKFFTILASVILFANPISSMQWVGTVLVFLGLGLDAKFGKGTKKTSH
uniprot
proteins
function
FUNCTION: ATP:ADP antiporter that catalyzes the exchange of ATP and ADP across the endoplasmic reticulum (ER) membrane (By similarity). Imports ATP from the cytosol to the ER lumen and exports ADP in the opposite direction (By similarity). Regulates ER energy metabolism and protein biogenesis (By similarity). Appears to be part of a calcium-dependent ER to cytosol low energy response axis, where calcium efflux from ER to the cytosol triggers ATP import into the ER lumen to maintain sufficient ATP supply (By similarity). Provides ATP to ER chaperone HSPA5 that drives protein folding and trafficking in the ER (By similarity). Can transport dATP, UTP or UDP in exchange for ATP, but the physiological relevance of this process remains to be established (By similarity). {ECO:0000250|UniProtKB:P78383}.
uniprot
proteins
mass_dalton
35817
uniprot
proteins
protein_family
Nucleotide-sugar transporter family
uniprot
proteins
protein_family
SLC35B subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9010752
uniprot
proteins
sequence_length
322
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P78383}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P78383}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P78383"; TRANSMEM 51..71; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P78383"; TRANSMEM 85..105; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P78383"; TRANSMEM 109..131; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P78383"; TRANSMEM 138..156; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P78383"; TRANSMEM 174..189; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P78383"; TRANSMEM 205..222; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P78383"; TRANSMEM 239..259; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P78383"; TRANSMEM 267..287; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:P78383"; TRANSMEM 294..313; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:P78383
uniprot
proteins