ASB7
entrez
140460
canonical
uniprot
Q9H672
canonical
ensembl
ENSG00000183475
resolver
ensp
ENSP00000328327
resolver
ensp
ENSP00000339819
resolver
genesymbol
ASB7
resolver
hgnc
HGNC:17182
resolver
uniprot
A8K1E5
resolver
uniprot
Q6GSJ6
resolver
uniprot
Q7Z4S3
resolver
uniprot_entry
ASB7_HUMAN
resolver
uniprot_sec
A8K1E5
resolver
uniprot_sec
Q6GSJ6
resolver
uniprot_sec
Q7Z4S3
resolver
amino_acid_sequence
MLHHHCRRNPELQEELQIQAAVAAGDVHTVRKMLEQGYSPNGRDANGWTLLHFSAARGKERCVRVFLEHGADPTVKDLIGGFTALHYAAMHGRARIARLMLESEYRSDIINAKSNDGWTPLHVAAHYGRDSFVRLLLEFKAEVDPLSDKGTTPLQLAIIRERSSCVKILLDHNANIDIQNGFLLRYAVIKSNHSYCRMFLQRGADTNLGRLEDGQTPLHLSALRDDVLCARMLYNYGADTNTRNYEGQTPLAVSISISGSSRPCLDFLQEVTRQPRNLQDLCRIKIRQCIGLQNLKLLDELPIAKVMKDYLKHKFDDI
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as LZTS1, PSRC1 and SUV39H1 (PubMed:16325183, PubMed:27697924, PubMed:39039081, PubMed:40440427). The ECS(ASB7) complex acts as a negative regulator of H3K9me3 histone mark by mediating ubiquitination and degradation of SUV39H1: ASB7 is recruited to heterochromatin by CBX5 (HP1 alpha), where it associates with SUV39H1, promoting the ubiquitin-proteasome-mediated degradation of SUV39H1 (PubMed:40440427). During mitosis, ASB7 is phosphorylated and inactivated, allowing SUV39H1 activity (PubMed:40440427). The ECS(ASB7) complex also plays a role in spindle dynamics and genome integrity by targeting the mitotic progression protein PSRC1 for proteasomal degradation in a cell cycle-dependent manner (PubMed:27697924). Also participates in meiosis by mediating the proper attachment between kinetochores and microtubules (By similarity). {ECO:0000250|UniProtKB:Q91ZU0, ECO:0000269|PubMed:16325183, ECO:0000269|PubMed:27697924, ECO:0000269|PubMed:39039081, ECO:0000269|PubMed:40440427}.
uniprot
proteins
mass_dalton
36011
uniprot
proteins
mutagenesis
MUTAGEN 65..67; /note="VFL->AFA: Abolished interaction with CBX5, preventing recruitment to heterochromatin."; /evidence="ECO:0000269|PubMed:40440427"; MUTAGEN 82; /note="F->A: Strongly decreased affinity for LZTS1 substrate."; /evidence="ECO:0000269|PubMed:39039081"; MUTAGEN 87; /note="Y->A: Does not affect affinity for LZTS1 substrate."; /evidence="ECO:0000269|PubMed:39039081"; MUTAGEN 116; /note="D->A: Decreased affinity for LZTS1 substrate."; /evidence="ECO:0000269|PubMed:39039081"; MUTAGEN 118; /note="W->A: Strongly decreased affinity for LZTS1 substrate."; /evidence="ECO:0000269|PubMed:39039081"; MUTAGEN 119; /note="T->A: Abolished phosphorylation by CDK1; when associated with A-152 and A-216."; /evidence="ECO:0000269|PubMed:40440427"; MUTAGEN 119; /note="T->E: Mimics phosphorylation; strongly decreased ability to promote SUV39H1 ubiquitination; when associated with A-152 and A-216."; /evidence="ECO:0000269|PubMed:40440427"; MUTAGEN 126; /note="H->A: Does not affect affinity for LZTS1 substrate."; /evidence="ECO:0000269|PubMed:39039081"; MUTAGEN 127; /note="Y->A: Does not affect affinity for LZTS1 substrate."; /evidence="ECO:0000269|PubMed:39039081"; MUTAGEN 147; /note="S->A: Strongly decreased affinity for LZTS1 substrate."; /evidence="ECO:0000269|PubMed:39039081"; MUTAGEN 151; /note="T->A: Strongly decreased affinity for LZTS1 substrate."; /evidence="ECO:0000269|PubMed:39039081"; MUTAGEN 152; /note="T->A: Abolished phosphorylation by CDK1; when associated with A-119 and A-216."; /evidence="ECO:0000269|PubMed:40440427"; MUTAGEN 152; /note="T->E: Mimics phosphorylation; strongly decreased ability to promote SUV39H1 ubiquitination; when associated with A-119 and A-216."; /evidence="ECO:0000269|PubMed:40440427"; MUTAGEN 160; /note="R->A: Decreased affinity for LZTS1 substrate."; /evidence="ECO:0000269|PubMed:39039081"; MUTAGEN 182; /note="F->A: Decreased affinity for LZTS1 substrate."; /evidence="ECO:0000269|PubMed:39039081"; MUTAGEN 185; /note="R->A: Decreased affinity for LZTS1 substrate."; /evidence="ECO:0000269|PubMed:39039081"; MUTAGEN 186; /note="Y->A: Does not affect affinity for LZTS1 substrate."; /evidence="ECO:0000269|PubMed:39039081"; MUTAGEN 189; /note="I->A: Does not affect affinity for LZTS1 substrate."; /evidence="ECO:0000269|PubMed:39039081"; MUTAGEN 216; /note="T->A: Abolished phosphorylation by CDK1; when associated with A-119 and A-152."; /evidence="ECO:0000269|PubMed:40440427"; MUTAGEN 216; /note="T->E: Mimics phosphorylation; strongly decreased ability to promote SUV39H1 ubiquitination; when associated with A-119 and A-152."; /evidence="ECO:0000269|PubMed:40440427
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:16325183, ECO:0000269|PubMed:27697924, ECO:0000269|PubMed:39039081, ECO:0000269|PubMed:40440427}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CDK1 during mitosis, preventing its association with SUV39H1 substrate. {ECO:0000269|PubMed:40440427}.
uniprot
proteins
protein_family
Ankyrin SOCS box (ASB) family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16325183
uniprot
proteins
pubmed
27697924
uniprot
proteins
pubmed
39039081
uniprot
proteins
pubmed
40440427
uniprot
proteins
sequence_length
318
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:40440427}. Nucleus {ECO:0000250|UniProtKB:Q91ZU0}. Note=Localizes to heterochromatin; recruited to heterochromatin by CBX5 (HP1 alpha). {ECO:0000269|PubMed:40440427}.
uniprot
proteins