Dao
entrez
13142
canonical
uniprot
P18894
canonical
ensembl
ENSMUSG00000042096
resolver
ensp
ENSMUSP00000083792
resolver
ensp
ENSMUSP00000107911
resolver
ensp
ENSMUSP00000125588
resolver
enst
ENSMUST00000086599
resolver
enst
ENSMUST00000112292
resolver
enst
ENSMUST00000161610
resolver
genesymbol
Dao
resolver
genesymbol_syn
Dao1
resolver
uniprot
A0A0R4J203
resolver
uniprot
F6W9X2
resolver
uniprot
Q64465
resolver
uniprot
Q8VCW7
resolver
uniprot
Q91WH3
resolver
uniprot_entry
F6W9X2_MOUSE
resolver
uniprot_entry
OXDA_MOUSE
resolver
uniprot_entry
Q91WH3_MOUSE
resolver
uniprot_sec
A0A0R4J203
resolver
uniprot_sec
Q64465
resolver
uniprot_sec
Q8VCW7
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by benzoate and thiolactomycin (PubMed:20567862, PubMed:20603179). Inhibited by 6-chloro-1,2-benzisoxazol-3(2H)-one (CBIO) and luvadaxistat (PubMed:33484270, PubMed:37289348). Meso-tartrate has no effect on activity (PubMed:20567862). {ECO:0000269|PubMed:20567862, ECO:0000269|PubMed:20603179, ECO:0000269|PubMed:33484270, ECO:0000269|PubMed:37289348}.
uniprot
proteins
amino_acid_sequence
MRVAVIGAGVIGLSTALCIHERYHPTQPLHMKIYADRFTPFTTSDVAAGLWQPYLSDPSNPQEAEWSQQTFDYLLSCLHSPNAEKMGLALISGYNLFRDEVPDPFWKNAVLGFRKLTPSEMDLFPDYGYGWFNTSLLLEGKSYLPWLTERLTERGVKLIHRKVESLEEVARGVDVIINCTGVWAGALQADASLQPGRGQIIQVEAPWIKHFILTHDPSLGIYNSPYIIPGSKTVTLGGIFQLGNWSGLNSVRDHNTIWKSCCKLEPTLKNARIVGELTGFRPVRPQVRLEREWLHFGSSSAEVIHNYGHGGYGLTIHWGCAMEAANLFGKILEEKKLSRLPPSHL
uniprot
proteins
ec_number
1.4.3.3
uniprot
proteins
function
FUNCTION: Catalyzes the oxidative deamination of D-amino acids with broad substrate specificity (PubMed:11419736, PubMed:1346751, PubMed:1355365, PubMed:16141519, PubMed:17042912, PubMed:20567862, PubMed:20603179, PubMed:24194108, PubMed:33484270, PubMed:8100053, Ref.36). Required to catabolize D-amino acids synthesized endogenously, of gastrointestinal bacterial origin or obtained from the diet, and to use these as nutrients (PubMed:24194108, PubMed:27670111, PubMed:6147398, PubMed:7901999, Ref.33, Ref.36). Regulates the level of D-amino acid neurotransmitters in the brain, such as D-serine, a co-agonist of N-methyl D-aspartate (NMDA) receptors, and may modulate synaptic transmission (PubMed:11419736, PubMed:29532193, PubMed:8100053). Catalyzes the first step of the racemization of D-DOPA to L-DOPA, for possible use in an alternative dopamine biosynthesis pathway (PubMed:17042912). Also catalyzes the first step of the chiral inversion of N(gamma)-nitro-D-arginine methyl ester (D-NNA) to its L-enantiomer L-NNA that acts as a nitric oxide synthase inhibitor (PubMed:20564560). The hydrogen peroxide produced in the reaction provides protection against microbial infection; it contributes to the oxidative killing activity of phagocytic leukocytes and protects against bacterial colonization of the small intestine (PubMed:22271930, PubMed:25425233, PubMed:27670111). Enzyme secreted into the lumen of the intestine may not be catalytically active and could instead be proteolytically cleaved into peptides with antimicrobial activity (PubMed:33484270). The hydrogen peroxide produced in the reaction may also play a role in promoting cellular senescence in response to DNA damage (By similarity). Could act as a detoxifying agent which removes D-amino acids accumulated during aging (By similarity). {ECO:0000250|UniProtKB:O35078, ECO:0000250|UniProtKB:P14920, ECO:0000269|PubMed:11419736, ECO:0000269|PubMed:1346751, ECO:0000269|PubMed:1355365, ECO:0000269|PubMed:16141519, ECO:0000269|PubMed:17042912, ECO:0000269|PubMed:20564560, ECO:0000269|PubMed:20567862, ECO:0000269|PubMed:20603179, ECO:0000269|PubMed:22271930, ECO:0000269|PubMed:24194108, ECO:0000269|PubMed:25425233, ECO:0000269|PubMed:27670111, ECO:0000269|PubMed:29532193, ECO:0000269|PubMed:33484270, ECO:0000269|PubMed:6147398, ECO:0000269|PubMed:7901999, ECO:0000269|PubMed:8100053, ECO:0000269|Ref.33, ECO:0000269|Ref.36}.
uniprot
proteins
mass_dalton
38652
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in the cerebellum; probably not by PRKACA, PRKCA or PRKCE. {ECO:0000250|UniProtKB:P14920}.; PTM: May be S-nitrosylated, which partially inactivates the enzyme. {ECO:0000250|UniProtKB:P14920}.
uniprot
proteins
protein_family
DAMOX/DASOX family
uniprot
proteins
pubmed
11114476
uniprot
proteins
pubmed
11419736
uniprot
proteins
pubmed
1346751
uniprot
proteins
pubmed
1355365
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15996778
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16141519
uniprot
proteins
pubmed
16843004
uniprot
proteins
pubmed
1686595
uniprot
proteins
pubmed
17042912
uniprot
proteins
pubmed
17874293
uniprot
proteins
pubmed
18940194
uniprot
proteins
pubmed
19117914
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19751394
uniprot
proteins
pubmed
1976103
uniprot
proteins
pubmed
20564560
uniprot
proteins
pubmed
20567862
uniprot
proteins
pubmed
20603179
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22203986
uniprot
proteins
pubmed
22271930
uniprot
proteins
pubmed
24194108
uniprot
proteins
pubmed
25425233
uniprot
proteins
pubmed
25816902
uniprot
proteins
pubmed
26833794
uniprot
proteins
pubmed
27670111
uniprot
proteins
pubmed
2895696
uniprot
proteins
pubmed
2904113
uniprot
proteins
pubmed
2904279
uniprot
proteins
pubmed
2906843
uniprot
proteins
pubmed
29194436
uniprot
proteins
pubmed
29532193
uniprot
proteins
pubmed
30938755
uniprot
proteins
pubmed
31309542
uniprot
proteins
pubmed
33484270
uniprot
proteins
pubmed
35915065
uniprot
proteins
pubmed
36429117
uniprot
proteins
pubmed
37289348
uniprot
proteins
pubmed
37440119
uniprot
proteins
pubmed
6147398
uniprot
proteins
pubmed
7901999
uniprot
proteins
pubmed
7903300
uniprot
proteins
pubmed
8100053
uniprot
proteins
pubmed
9133654
uniprot
proteins
sequence_length
345
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome matrix {ECO:0000269|PubMed:1686595}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:P14920}. Presynaptic active zone {ECO:0000250|UniProtKB:O35078}. Secreted {ECO:0000269|PubMed:27670111, ECO:0000269|PubMed:33484270}. Note=Transiently present in the cytosol before being delivered to the peroxisomes (By similarity). In the cerebellum, a fraction of protein localizes to the presynaptic active zone, where its activity is regulated by protein BSN (By similarity). Secreted into the lumen of the small intestine (PubMed:27670111, PubMed:33484270). {ECO:0000250|UniProtKB:O35078, ECO:0000250|UniProtKB:P14920, ECO:0000269|PubMed:27670111, ECO:0000269|PubMed:33484270}.
uniprot
proteins