FST
entrez
10468
canonical
uniprot
P19883
canonical
ensembl
ENSG00000134363
resolver
ensp
ENSP00000256759
resolver
ensp
ENSP00000380151
resolver
ensp
ENSP00000571973
resolver
genesymbol
FST
resolver
hgnc
HGNC:3971
resolver
uniprot
B5BU94
resolver
uniprot
Q9BTH0
resolver
uniprot_entry
FST_HUMAN
resolver
uniprot_sec
B5BU94
resolver
uniprot_sec
Q9BTH0
resolver
amino_acid_sequence
MVRARHQPGGLCLLLLLLCQFMEDRSAQAGNCWLRQAKNGRCQVLYKTELSKEECCSTGRLSTSWTEEDVNDNTLFKWMIFNGGAPNCIPCKETCENVDCGPGKKCRMNKKNKPRCVCAPDCSNITWKGPVCGLDGKTYRNECALLKARCKEQPELEVQYQGRCKKTCRDVFCPGSSTCVVDQTNNAYCVTCNRICPEPASSEQYLCGNDGVTYSSACHLRKATCLLGRSIGLAYEGKCIKAKSCEDIQCTGGKKCLWDFKVGRGRCSLCDELCPDSKSDEPVCASDNATYASECAMKEAACSSGVLLEVKHSGSCNSISEDTEEEEEDEDQDYSFPISSILEW
uniprot
proteins
function
FUNCTION: Multifunctional regulatory protein whose primary function is to antagonize members of the transforming growth factor beta (TGF-beta) superfamily including activin, myostatin, GDF11 or bone morphogenetic proteins (BMPs) (PubMed:11279126, PubMed:16482217, PubMed:18535106). Mechanistically, binds to these ligands in the extracellular space, blocking their type II receptor-binding site to inhibit downstream signaling (PubMed:16482217). Plays an essential role in muscle fiber formation and growth both by preventing the repressive effects of myostatin and through SMAD3/AKT/mTOR signaling independently of myostatin (By similarity). Also promotes neural differentiation by antagonizing the action BMP4 (By similarity). Acts as a specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) by sequestering activin A/INHBA (PubMed:11279126). On the other hand, translocates into the nucleus where it down-regulates rRNA synthesis and ribosome biogenesis to maintain cellular energy homeostasis by binding to rDNA. {ECO:0000250|UniProtKB:P47931, ECO:0000269|PubMed:11279126, ECO:0000269|PubMed:16482217, ECO:0000269|PubMed:18535106}.
uniprot
proteins
mass_dalton
38007
uniprot
proteins
mutagenesis
MUTAGEN 33; /note="W->A: More than 90% loss of binding to activin A/INHBA and FSH secretion inhibition."; /evidence="ECO:0000269|PubMed:11279126"; MUTAGEN 52; /note="K->A: About 30% of binding to activin A/INHBA."; /evidence="ECO:0000269|PubMed:11279126"; MUTAGEN 55; /note="C->A: More than 95% loss of binding to activin A/INHBA and FSH secretion inhibition; when associated with A-56."; /evidence="ECO:0000269|PubMed:11279126"; MUTAGEN 56; /note="C->A: More than 95% loss of binding to activin A/INHBA and FSH secretion inhibition; when associated with A-55."; /evidence="ECO:0000269|PubMed:11279126"; MUTAGEN 163; /note="R->A: Complete loss of binding to activin A/INHBA."; /evidence="ECO:0000269|PubMed:16482217
uniprot
proteins
pubmed
11279126
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15472207
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16198295
uniprot
proteins
pubmed
16482217
uniprot
proteins
pubmed
17409095
uniprot
proteins
pubmed
18535106
uniprot
proteins
pubmed
19054851
uniprot
proteins
pubmed
19644449
uniprot
proteins
pubmed
20843798
uniprot
proteins
pubmed
28257634
uniprot
proteins
pubmed
31215115
uniprot
proteins
pubmed
3380788
uniprot
proteins
sequence_length
344
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11279126}. Nucleus, nucleolus {ECO:0000269|PubMed:20843798}.
uniprot
proteins