Akr1b7
entrez
116463
canonical
uniprot
Q5RJP0
canonical
ensembl
ENSRNOG00000009875
resolver
ensp
ENSRNOP00000013423
resolver
enst
ENSRNOT00000013423
resolver
genesymbol
Akr1b7
resolver
genesymbol_syn
Akr1b14
resolver
uniprot_entry
ALD1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by tolrestat and epalrestat. {ECO:0000269|PubMed:21048316}.
uniprot
proteins
amino_acid_sequence
MTTFVKLRTKAKMPLVGLGTWKSPPGQVKEAVKAAIDAGYRHFDCAYVYQNESEVGEAIQEKIKEKAVRREDLFIVSKLWSTFFEKSLMKEAFQKTLSDLKLDYLDLYLIHWPQGLQAGKEFLPKDSQGKVLMSKSTFLDAWEGMEELVDQGLVKALGVSNFNHFQIERLLNKPGLKHKPVTNQVECHPYLTQEKLIQYCHSKGIAVIAYSPLGSPDRPYAKPEDPVVLEIPKIKEIAAKHKKTIAQVLIRFHVQRNVAVIPKSVTLSHIKENIQVFDFQLSEEDMAAILSLNRNWRACGLFVTSDEEDFPFHEEY
uniprot
proteins
ec_number
1.1.1.21
uniprot
proteins
function
FUNCTION: Reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols (PubMed:21048316). Reduces prostaglandins (By similarity). May play a role in the metabolism of xenobiotic aromatic aldehydes. {ECO:0000250|UniProtKB:P21300, ECO:0000269|PubMed:21048316}.
uniprot
proteins
mass_dalton
36122
uniprot
proteins
mutagenesis
MUTAGEN 269; /note="H->F,R: Reduced affinity for NADP."; /evidence="ECO:0000269|PubMed:21168333"; MUTAGEN 269; /note="H->M: Strongly reduced affinity for NADP."; /evidence="ECO:0000269|PubMed:21168333
uniprot
proteins
protein_family
Aldo/keto reductase family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21048316
uniprot
proteins
pubmed
21168333
uniprot
proteins
sequence_length
316
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins