EFNA2
entrez
1943
canonical
uniprot
O43921
canonical
ensembl
ENSG00000099617
resolver
ensp
ENSP00000215368
resolver
enst
ENST00000215368
resolver
genesymbol
EFNA2
resolver
genesymbol_syn
EPLG6
resolver
genesymbol_syn
LERK6
resolver
hgnc
HGNC:3222
resolver
uniprot
O76020
resolver
uniprot_entry
EFNA2_HUMAN
resolver
uniprot_sec
O76020
resolver
amino_acid_sequence
MAPAQRPLLPLLLLLLPLPPPPFARAEDAARANSDRYAVYWNRSNPRFHAGAGDDGGGYTVEVSINDYLDIYCPHYGAPLPPAERMEHYVLYMVNGEGHASCDHRQRGFKRWECNRPAAPGGPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNAVDRPCLRLKVYVRPTNETLYEAPEPIFTSNNSCSSPGGCRLFLSTIPVLWTLLGS
uniprot
proteins
function
FUNCTION: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. With the EPHA2 receptor may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
23878
uniprot
proteins
protein_family
Ephrin family
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
19836338
uniprot
proteins
pubmed
9465306
uniprot
proteins
pubmed
9826538
uniprot
proteins
sequence_length
213
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-anchor {ECO:0000305}.
uniprot
proteins