Stk36
entrez
269209
canonical
uniprot
Q69ZM6
canonical
ensembl
ENSMUSG00000033276
resolver
ensp
ENSMUSP00000084430
resolver
ensp
ENSMUSP00000084433
resolver
ensp
ENSMUSP00000250077
resolver
genesymbol
Stk36
resolver
genesymbol_syn
Kiaa1278
resolver
uniprot
Q6PDI0
resolver
uniprot
Q80XQ6
resolver
uniprot_entry
STK36_MOUSE
resolver
uniprot_sec
Q6PDI0
resolver
uniprot_sec
Q80XQ6
resolver
amino_acid_sequence
MEKYHVLEMIGEGSFGRVYKGRKKYSAQVVALKFIPKLGRSEKELRNLQREIEIMRGLWHPNIVHMLDSFETDKEVVVVTDYAEGELFQILEDDGKLPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGIKLCDFGFARAMSTNTMVLTSIKGTPLYMSPELVEERPYDHTADLWSVGCILYELAVGTPPFYTTSIFQLVSLILKDPVRWPSTISSCFKNFLQGLLTKDPRQRLSWPDLLHHPFIAGRVTIITEPAGSDLGTPFTSRLPPELQVLKDEQAHRLAPKGNQSRILRQACKLMAEEAKQKEDQNAGSALEQEDGLCKVTPSTAPVPGLKATPQESSLLAGILASEMKNNWEDWGAGEAPRTSRENHINLECEQGFPEPRPEAMGRQSTDVVDPENEEPDSDDEWQRLLETSEPGPVQLKSPLTLLCNPDFCQRIQSQLRGTGEQILKGVLDGVSHLLPVLRILSSLLSSCNDSVLLYSFCQEAGLPELPLSLLRYSQESSSIQQQPWYGALLRDLVAVVQAYFSCTFNLERSQTGDSLQVFQEAASLFLDLLGKLLAQSDDSEQTFRRDSLMCFAVLCEAVDGNSWAVSKAFYSSLLTTQRAVLDGLLHGLTVPQLPFHTPPGAPQVSQPLREQSEDVPGAISSALAAMCTAPVGLPSCWDAKEQVSWHLANQLTEDSSQLRPSLISGLRHHVLCLHLLKVLYACCYISERLCHILGQEPLALESLLMLVQGKVKVADWEESTEVALYLLSLLVFRLQDLPSGMEKLGSEVATLFTHSHVVSLVNAAACLLGQLGQQGVTFDLQPREWIAAAAHALSAPAEVRLTPPYSCGFYDGLLILLLQLLMQVQGKPGLIRDVVGSEVWTILWHRFSMALRLPEEVSAQEDDLLLSSPSSLEPDWTLISPQGMAALLSLAMAIFTQESQLCLSHLSQHGSVLMLTLKHLLSPSFLHHLSQAPQGPEFLPVVVLSVCKLLCFPFALDVDADLLVGVLADLRASEVVVCLLQVCCHHLSLLQAELPIGLLTRLALTDSASLKQFVNTVATSSRAIISFLSVVLLSDQPLMISDLLSLLTHTARILSPSHLSFIQELLSGSDESYRPLRSLLGHSENTVRVRAYGLLGHLLQHSMALRGALQSQSGLLNLLLLGLGDKDPAVRRSASFAVGNAAYQAGPLGPALAAAVPSMTQLLGDAQDGIRRNAASALGNLGPEGLGKELLKCQVPQRLLEMACGDPQPTVKEAALIALRSLQQESCIHQVLVSLGASEKLALLSLGNQLLPNSSNRPASVRHCRKLIQLLRPTHST
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine protein kinase which plays an important role in the smoothened pathway by regulating the activity of GLI transcription factors (PubMed:18600476, PubMed:38096226). Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization (PubMed:38096226). Acts by mediating phosphorylation of GLI proteins, promoting their dissociation from SUFU (PubMed:38096226). Also catalyzes phosphorylation of ULK4 adapter (By similarity). GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur (By similarity). Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function (PubMed:16055717). Essential for construction of the central pair apparatus of motile cilia (PubMed:19305393). {ECO:0000250|UniProtKB:Q9NRP7, ECO:0000269|PubMed:16055717, ECO:0000269|PubMed:18600476, ECO:0000269|PubMed:19305393, ECO:0000269|PubMed:38096226}.
uniprot
proteins
mass_dalton
144180
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated at Thr-158 and Ser-159, activating the protein kinase activity. {ECO:0000250|UniProtKB:Q9NRP7}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Ser/Thr protein kinase family
uniprot
proteins
pubmed
10806483
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16055717
uniprot
proteins
pubmed
18600476
uniprot
proteins
pubmed
19305393
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
38096226
uniprot
proteins
sequence_length
1316
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:38096226}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q9NRP7}. Cytoplasm {ECO:0000269|PubMed:19305393}. Nucleus {ECO:0000250|UniProtKB:Q9NRP7}. Note=STK36 and ULK4 are mutually dependent for localization to ciliary tip. Low levels also present in the nucleus. {ECO:0000250|UniProtKB:Q9NRP7}.
uniprot
proteins