MACROD2
entrez
140733
canonical
uniprot
A1Z1Q3
canonical
ensembl
ENSG00000172264
resolver
ensp
ENSP00000217246
resolver
ensp
ENSP00000385290
resolver
ensp
ENSP00000507484
resolver
genesymbol
MACROD2
resolver
genesymbol_syn
C20orf133
resolver
hgnc
HGNC:16126
resolver
uniprot
A6NFF7
resolver
uniprot
B0QZ39
resolver
uniprot
B3KWV0
resolver
uniprot
Q0P6D5
resolver
uniprot
Q495E0
resolver
uniprot
Q5W199
resolver
uniprot
Q6ZN71
resolver
uniprot_entry
MACD2_HUMAN
resolver
uniprot_sec
A6NFF7
resolver
uniprot_sec
B0QZ39
resolver
uniprot_sec
B3KWV0
resolver
uniprot_sec
Q0P6D5
resolver
uniprot_sec
Q495E0
resolver
uniprot_sec
Q5W199
resolver
uniprot_sec
Q6ZN71
resolver
activity_regulation
ACTIVITY REGULATION: Subject to product inhibition by ADP-ribose. {ECO:0000269|PubMed:23474712}.
uniprot
proteins
amino_acid_sequence
MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDEENTQETSQVKKSLTEKVSLYRGDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPCLLAECRNLNGCDTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSSLKLVKENNIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDAGAQDEAKEQRNGTK
uniprot
proteins
ec_number
3.2.2.-
uniprot
proteins
ec_number
3.5.1.-
uniprot
proteins
function
FUNCTION: Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474712, PubMed:23474714). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474712, PubMed:23474714). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746). {ECO:0000269|PubMed:21257746, ECO:0000269|PubMed:23474712, ECO:0000269|PubMed:23474714}.
uniprot
proteins
mass_dalton
47421
uniprot
proteins
mutagenesis
MUTAGEN 92; /note="N->A: Reduced ADP-ribosyl hydrolase activity; when associated with A-102."; /evidence="ECO:0000269|PubMed:23474712"; MUTAGEN 100; /note="G->A: Abolished hydrolase activity and ability to bind ADP-D-ribose."; /evidence="ECO:0000269|PubMed:23474714"; MUTAGEN 102; /note="D->A: Reduced ADP-ribosyl hydrolase activity. Reduced ADP-ribosyl hydrolase activity; when associated with A-92."; /evidence="ECO:0000269|PubMed:23474712, ECO:0000269|PubMed:23474714"; MUTAGEN 106; /note="H->A: Reduced hydrolase activity."; /evidence="ECO:0000269|PubMed:23474714"; MUTAGEN 188; /note="G->E: Abolishes interaction with ADP-ribosylated proteins. Strongly reduced ADP-ribosyl hydrolase activity."; /evidence="ECO:0000269|PubMed:23474712
uniprot
proteins
protein_family
MacroD-type family
uniprot
proteins
protein_family
MacroD1/2-like subfamily
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18655026
uniprot
proteins
pubmed
21257746
uniprot
proteins
pubmed
23474712
uniprot
proteins
pubmed
23474714
uniprot
proteins
pubmed
31599159
uniprot
proteins
sequence_length
425
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23474712}. Note=Recruited to DNA lesions, probably via mono-APD-ribosylated proteins. {ECO:0000269|PubMed:23474712}.
uniprot
proteins