Tollip
entrez
361677
canonical
uniprot
A2RUW1
canonical
ensembl
ENSRNOG00000019861
resolver
ensembl
ENSRNOG00055030072
resolver
ensembl
ENSRNOG00060033172
resolver
ensembl
ENSRNOG00065027438
resolver
ensp
ENSRNOP00000049498
resolver
ensp
ENSRNOP00000087930
resolver
ensp
ENSRNOP00055043164
resolver
ensp
ENSRNOP00060047485
resolver
ensp
ENSRNOP00065038861
resolver
enst
ENSRNOT00000046344
resolver
enst
ENSRNOT00000103130
resolver
enst
ENSRNOT00055052228
resolver
enst
ENSRNOT00060057515
resolver
enst
ENSRNOT00065047375
resolver
genesymbol
Tollip
resolver
uniprot
A0A8I6A889
resolver
uniprot_entry
A0A8I6A889_RAT
resolver
uniprot_entry
TOLIP_RAT
resolver
amino_acid_sequence
MATTVSTQRGPVYIGELPQDFLRITPTQQQQQIQLDAQAAQQLQYGGAVGTVGRLSITVVQAKLAKNYGMTRMDPYCRLRLGYAVYETPTAHNGAKNPRWNKVIQCTVPPGVDSFYLEIFDERAFSMDDRIAWTHITIPESLKQGQVEDEWYSLSGRQGDDKEGMINLVMSYTSLPAAMMMPPQPVVLMPTVYQQGVGYVPIAGMPAVCSPGMVPMAMPPPAVAPQPRCNEEDLKAIQDMFPNMDREVIRSVLEAQRGNKDAAINSLLQMGEES
uniprot
proteins
function
FUNCTION: Component of the signaling pathway of IL-1 and Toll-like receptors (By similarity). Inhibits cell activation by microbial products (By similarity). Recruits IRAK1 to the IL-1 receptor complex (By similarity). Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates (By similarity). The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity). In a complex with TOM1, recruits ubiquitin-conjugated proteins onto early endosomes (By similarity). Binds to phosphatidylinositol 3-phosphate (PtdIns(3)P) (By similarity). {ECO:0000250|UniProtKB:Q9H0E2}.
uniprot
proteins
mass_dalton
30315
uniprot
proteins
protein_family
Tollip family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
274
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9H0E2}. Endosome {ECO:0000250|UniProtKB:Q9H0E2}. Early endosome {ECO:0000250|UniProtKB:Q9H0E2}. Note=Localized to endo/exosomal vesicles. {ECO:0000250|UniProtKB:Q9H0E2}.
uniprot
proteins