Map2k5
entrez
29568
canonical
uniprot
Q62862
canonical
ensembl
ENSRNOG00000007926
resolver
ensembl
ENSRNOG00055025959
resolver
ensembl
ENSRNOG00060020809
resolver
ensembl
ENSRNOG00065007900
resolver
ensp
ENSRNOP00000010991
resolver
ensp
ENSRNOP00000050528
resolver
ensp
ENSRNOP00000083354
resolver
enst
ENSRNOT00000114643
resolver
genesymbol
Map2k5
resolver
genesymbol_syn
Mek5
resolver
genesymbol_syn
Mkk5
resolver
genesymbol_syn
Prkmk5
resolver
uniprot
A0A8I5ZZ49
resolver
uniprot
Q62863
resolver
uniprot
Q62864
resolver
uniprot_entry
A0A8I5ZZ49_RAT
resolver
uniprot_entry
MP2K5_RAT
resolver
uniprot_sec
Q62863
resolver
uniprot_sec
Q62864
resolver
amino_acid_sequence
MLWLALGPFRAMENQVLVIRIKIPNSGAVDWTVHSGPQLLFRDVLDVIGQVLPEATTTAFEYEDEDGDRITVRSDEEMKAMLSYYYSTVMEQQVNGQLIEPLQIFPRACKPPGERNIHGLKVNTRAGPSQHTSPVVSDSLPSNSLKKSSAELRKILANGQMNEQDIRYRDTLGHGNGGTVYKAYHVPSGKILAVKVILLDITLELQKQIMSELEILYKCDSSYIIGFYGAFFVENRISICTEFMDGGSLDVYRKIPEHVLGRIAVAVVKGLTYLWSLKILHRDVKPSNMLVNTSGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISGEQYGIHSDVWSLGISFMELALGRFPYPQIQKNQGSLMPLQLLQCIVDEDSPVLPLGEFSEPFVHFITQCMRKQPKERPAPEELMGHPFIVQFNDGNATVVSMWVCRALEERRSQQGPP
uniprot
proteins
ec_number
2.7.12.2
uniprot
proteins
function
FUNCTION: Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis (By similarity). As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM (PubMed:20724525). {ECO:0000250, ECO:0000269|PubMed:20724525, ECO:0000269|PubMed:7499418}.
uniprot
proteins
mass_dalton
50198
uniprot
proteins
mutagenesis
MUTAGEN 311; /note="S->D: No change in activity."; /evidence="ECO:0000269|PubMed:7499418"; MUTAGEN 315; /note="T->D: No change in activity."; /evidence="ECO:0000269|PubMed:7499418
uniprot
proteins
post_translational_modification
PTM: Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases. {ECO:0000250}.
uniprot
proteins
protein_family
MAP kinase kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20724525
uniprot
proteins
pubmed
7499418
uniprot
proteins
sequence_length
448
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform Beta]: Cytoplasm, cytosol.; SUBCELLULAR LOCATION: [Isoform Alpha-1]: Membrane. Note=The alternatively spliced exon in alpha isoform resemble conserved sequences that mediate interactions with the cytoskeleton, thereby explaining the differential localization.; SUBCELLULAR LOCATION: [Isoform Alpha-2]: Membrane. Note=The alternatively spliced exon in alpha isoform resemble conserved sequences that mediate interactions with the cytoskeleton, thereby explaining the differential localization.
uniprot
proteins