Pclaf
entrez
68026
canonical
uniprot
Q9CQX4
canonical
ensembl
ENSMUSG00000040204
resolver
ensp
ENSMUSP00000038877
resolver
enst
ENSMUST00000045802
resolver
genesymbol
Pclaf
resolver
genesymbol_syn
Ns5atp9
resolver
genesymbol_syn
Paf
resolver
uniprot
Q4VAG2
resolver
uniprot
Q9CZ17
resolver
uniprot
Q9D0A5
resolver
uniprot_entry
PAF15_MOUSE
resolver
uniprot_sec
Q4VAG2
resolver
uniprot_sec
Q9CZ17
resolver
uniprot_sec
Q9D0A5
resolver
amino_acid_sequence
MVRTKANYVPGAYRKAVASQAPRKVLGSSTFVTNSSSSSRKAENKYAGGNPVCVRPTPKWQKGIGEFFRLSPKESKKENQAPEEAGTSGLGKAKRKACPLQPDHRDDENE
uniprot
proteins
function
FUNCTION: PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
11993
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated at Lys-15 and Lys-24 during normal S phase, promoting its association with PCNA. Also diubiquitinated at these 2 sites. Following DNA damage, monoubiquitin chains at Lys-15 and Lys-24 are probably extended, leading to disrupt the interaction with PCNA. Polyubiquitinated by the APC/C complex at the mitotic exit, leading to its degradation by the proteasome (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
110
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q15004}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q15004}. Note=Following DNA damage, localizes to DNA damage sites. Colocalizes with centrosomes in perinuclear region. {ECO:0000250|UniProtKB:Q15004}.
uniprot
proteins