EPS15
entrez
2060
canonical
uniprot
P42566
canonical
ensembl
ENSG00000085832
resolver
ensp
ENSP00000360798
resolver
ensp
ENSP00000516332
resolver
ensp
ENSP00000516334
resolver
ensp
ENSP00000516336
resolver
ensp
ENSP00000559437
resolver
ensp
ENSP00000559438
resolver
ensp
ENSP00000559448
resolver
enst
ENST00000706288
resolver
enst
ENST00000706292
resolver
genesymbol
EPS15
resolver
genesymbol_syn
AF1P
resolver
hgnc
HGNC:3419
resolver
uniprot
A0A994J5A3
resolver
uniprot
A0A994J5J3
resolver
uniprot
B2R8J7
resolver
uniprot
B7Z240
resolver
uniprot
D3DPJ2
resolver
uniprot
Q5SRH4
resolver
uniprot_entry
A0A994J5A3_HUMAN
resolver
uniprot_entry
A0A994J5J3_HUMAN
resolver
uniprot_entry
B7Z240_HUMAN
resolver
uniprot_entry
EPS15_HUMAN
resolver
uniprot_sec
B2R8J7
resolver
uniprot_sec
D3DPJ2
resolver
uniprot_sec
Q5SRH4
resolver
amino_acid_sequence
MAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASLQKNIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQLNWCSSPHSILVNGATDYCSLSTSSSETANLNEHVEGQSNLESEPIHQESPARSSPELLPSGVTDENEVTTAVTEKVCSELDNNRHSKEEDPFNVDSSSLTGPVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFRQSTDPFATSSTDPFSAANNSSITSVETLKHNDPFAPGGTVVAASDSATDPFASVFGNESFGGGFADFSTLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSEDEPPALPPKIGTPTRPCPLPPGKRSINKLDSPDPFKLNDPFQPFPGNDSPKEKDPEIFCDPFTSATTTTNKEADPSNFANFSAYPSEEDMIEWAKRESEREEEQRLARLNQQEQEDLELAIALSKSEISEA
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving EPS15 is found in acute leukemias. Translocation t(1;11)(p32;q23) with KMT2A/MLL1. The result is a rogue activator protein.
uniprot
proteins
function
FUNCTION: Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}.
uniprot
proteins
mass_dalton
98656
uniprot
proteins
mutagenesis
MUTAGEN 154; /note="V->E: Loss of interaction with STON2 NPF motifs."; /evidence="ECO:0000269|PubMed:18200045"; MUTAGEN 169; /note="W->A: Loss of interaction with STON2 NPF motifs."; /evidence="ECO:0000269|PubMed:18200045
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Tyr-849 is involved in the internalization of EGFR. Not required for membrane translocation after EGF treatment or for targeting to coated pits, but essential for a subsequent step in EGFR endocytosis (By similarity). Phosphorylated on serine upon DNA damage, probably by ATM or ATR. {ECO:0000250}.; PTM: Ubiquitinated. {ECO:0000250|UniProtKB:P42567}.
uniprot
proteins
pubmed
10393179
uniprot
proteins
pubmed
10757979
uniprot
proteins
pubmed
11062555
uniprot
proteins
pubmed
12551915
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16159959
uniprot
proteins
pubmed
16314522
uniprot
proteins
pubmed
16325581
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16903783
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18199683
uniprot
proteins
pubmed
18200045
uniprot
proteins
pubmed
18362181
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19458185
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20448150
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21762413
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22484487
uniprot
proteins
pubmed
22648170
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24768539
uniprot
proteins
pubmed
26822536
uniprot
proteins
pubmed
27670116
uniprot
proteins
pubmed
8134107
uniprot
proteins
pubmed
8183552
uniprot
proteins
pubmed
8662907
uniprot
proteins
pubmed
9721102
uniprot
proteins
pubmed
9723620
uniprot
proteins
sequence_length
896
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Recruited to the plasma membrane upon EGFR activation and localizes to coated pits. Colocalizes with UBQLN1 in ubiquitin-rich cytoplasmic aggregates that are not endocytic compartments and in cytoplasmic juxtanuclear structures called aggresomes. {ECO:0000269|PubMed:16159959}.; SUBCELLULAR LOCATION: [Isoform 2]: Early endosome membrane {ECO:0000269|PubMed:18362181}; Peripheral membrane protein {ECO:0000269|PubMed:18362181}; Cytoplasmic side {ECO:0000269|PubMed:18362181}. Note=Colocalizes with HGS on bilayered clathrin coats on endosomes.
uniprot
proteins