BDNF
entrez
627
canonical
uniprot
P23560
canonical
ensembl
ENSG00000176697
resolver
ensp
ENSP00000320002
resolver
ensp
ENSP00000349084
resolver
ensp
ENSP00000379302
resolver
ensp
ENSP00000379305
resolver
ensp
ENSP00000379309
resolver
ensp
ENSP00000389345
resolver
ensp
ENSP00000400502
resolver
ensp
ENSP00000414303
resolver
ensp
ENSP00000432035
resolver
ensp
ENSP00000432376
resolver
ensp
ENSP00000435564
resolver
ensp
ENSP00000435805
resolver
ensp
ENSP00000437138
resolver
ensp
ENSP00000605893
resolver
ensp
ENSP00000605894
resolver
ensp
ENSP00000773984
resolver
genesymbol
BDNF
resolver
hgnc
HGNC:1033
resolver
uniprot
A0A0E3SU01
resolver
uniprot
A7LA85
resolver
uniprot
A7LA92
resolver
uniprot
D3DQZ2
resolver
uniprot
Q598Q1
resolver
uniprot
Q6DN19
resolver
uniprot
Q6YNR2
resolver
uniprot
Q6YNR3
resolver
uniprot
Q9BYY7
resolver
uniprot
Q9UC24
resolver
uniprot_entry
A0A0E3SU01_HUMAN
resolver
uniprot_entry
BDNF_HUMAN
resolver
uniprot_sec
A7LA85
resolver
uniprot_sec
A7LA92
resolver
uniprot_sec
D3DQZ2
resolver
uniprot_sec
Q598Q1
resolver
uniprot_sec
Q6DN19
resolver
uniprot_sec
Q6YNR2
resolver
uniprot_sec
Q6YNR3
resolver
uniprot_sec
Q9BYY7
resolver
uniprot_sec
Q9UC24
resolver
amino_acid_sequence
MTILFLTMVISYFGCMKAAPMKEANIRGQGGLAYPGVRTHGTLESVNGPKAGSRGLTSLADTFEHVIEELLDEDQKVRPNEENNKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCTLTIKRGR
uniprot
proteins
function
FUNCTION: Important signaling molecule that activates signaling cascades downstream of NTRK2 (PubMed:11152678). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. {ECO:0000269|PubMed:11152678, ECO:0000269|PubMed:12553913, ECO:0000269|PubMed:29909994}.; FUNCTION: [Neurotrophic factor BDNF precursor form]: Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2 (PubMed:24908487, PubMed:29909994). Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse (By similarity). {ECO:0000250|UniProtKB:P21237, ECO:0000269|PubMed:24908487, ECO:0000269|PubMed:29909994}.
uniprot
proteins
mass_dalton
27818
uniprot
proteins
mutagenesis
MUTAGEN 54; /note="R->A: Abolishes processing by MBTPS1."; /evidence="ECO:0000269|PubMed:11152678
uniprot
proteins
post_translational_modification
PTM: [Neurotrophic factor BDNF precursor form]: N-glycosylated and glycosulfated, contrary to mature BDNF. {ECO:0000269|PubMed:11152678, ECO:0000269|PubMed:19467646}.; PTM: Mature BDNF is produced by proteolytic removal of the propeptide, catalyzed by a FURIN family member. In addition, the precursor form is proteolytically cleaved within the propeptide, but this is not an obligatory intermediate for the production of mature BDNF (PubMed:11152678). Can be converted into mature BDNF by plasmin (PLG) (PubMed:19467646). {ECO:0000269|PubMed:11152678, ECO:0000269|PubMed:19467646}.
uniprot
proteins
protein_family
NGF-beta family
uniprot
proteins
pubmed
10391209
uniprot
proteins
pubmed
10631974
uniprot
proteins
pubmed
11152678
uniprot
proteins
pubmed
11214319
uniprot
proteins
pubmed
11840487
uniprot
proteins
pubmed
12553913
uniprot
proteins
pubmed
12836135
uniprot
proteins
pubmed
12888803
uniprot
proteins
pubmed
1339267
uniprot
proteins
pubmed
14566559
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15115760
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15666411
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
17629449
uniprot
proteins
pubmed
18753648
uniprot
proteins
pubmed
1889806
uniprot
proteins
pubmed
19467646
uniprot
proteins
pubmed
2025430
uniprot
proteins
pubmed
2236018
uniprot
proteins
pubmed
24908487
uniprot
proteins
pubmed
28397838
uniprot
proteins
pubmed
29909994
uniprot
proteins
pubmed
7703225
uniprot
proteins
pubmed
8527932
uniprot
proteins
sequence_length
247
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11152678, ECO:0000269|PubMed:19467646, ECO:0000269|PubMed:8527932}.; SUBCELLULAR LOCATION: [Neurotrophic factor BDNF precursor form]: Secreted {ECO:0000269|PubMed:11152678, ECO:0000269|PubMed:19467646}. Note=A proportion of BDNF is secreted as immature precursor (proBDNF). {ECO:0000269|PubMed:11152678, ECO:0000269|PubMed:19467646}.
uniprot
proteins