Ccdc146
entrez
75172
canonical
uniprot
E9Q9F7
canonical
ensembl
ENSMUSG00000064280
resolver
ensp
ENSMUSP00000110900
resolver
enst
ENSMUST00000115245
resolver
genesymbol
Ccdc146
resolver
uniprot
Q5DTX2
resolver
uniprot
Q9D511
resolver
uniprot_entry
CC146_MOUSE
resolver
uniprot_entry
Q9D511_MOUSE
resolver
uniprot_sec
Q5DTX2
resolver
amino_acid_sequence
MEYNSKDAEEETEDEEEGLKEAEGEEQEKEEVTATSETDDDQEDLPSVLVPTVNIREERLINLAETPAFLCLHELHSKGKLPGTRMAELKAKYTLLHDTVVSTQESEVQLLENAKRFTEQIQQQQVCLQQAEDFPNVFTTEVCKLREQLLKYQNEYTAAQEREYNIQYRLTSLTEEKSIILKEFEKIPKPGEIEKKTRLLKESTEELRKEVIQRRLEIKNLREDVVLKQKQLVREQKELEELMEYQVGLKDDVVHHQSVPVQITKEIEKMTRKKVETEKKNIVLESELKELSDSLKKLENKVNTLAEERDDIMKEVEGKRTLLEVKEREYGQLLKLLELTKENEASSLAERGILDINLRNCLIDKQNYHDELSRKQREKERDFRNLKKTELLLKVSLDALTQAQAMNQRLLLEMEAIPKEYLTLPERRKELHKEVDLARRNLAQQKSLSEAEAKLVEQQIAQENKLLKEQESLRELVFNLGRMTQIKIDEKEQKAKDFLKAQRRYSEIVKEIKSKDLEIRLYKKRKHEIHRRLREFASLYDTIRNERNKFVNLLHKAHQKVNEIKERLKMSLNELEILRNSAVSQERKLQNAMLKHSNNVTIKESIQNDVCKITAKLQEMKEKKEAQLTSMDRLASMITVIEEEMVQLRKKYEKAVQRRNESGVQLIEREEEVCIFYEKVNVQEKIKLHQDVEIHILEEKIRFLKLRIAEKQRQISVTRKLVPIKKSLDADLAVIQIQFSQCTDRIKDLEKLFVNPDSKGRVRFIKGKDLTEEEMIKKLDMLELQIAKKEEKLLEKDFIYEQVSQLTNRLKGKTQACKKDTLLLAKKMNSYQQKIKVVTQEMMALVAELSMKQALTIELQKEVREKEEFIFSCSARIEKGLPLNREIEKDWLKVLRDEEMYAFATAEMSREYMETDYRQLPNGVYTTAEQRPNAYMPEADTELPLPKPYGAMAPFKPSEPGANRRHIRKPVVKPIEI
uniprot
proteins
function
FUNCTION: Essential for sperm flagellum biogenesis and male fertility. {ECO:0000269|PubMed:38038747, ECO:0000269|PubMed:38441556}.
uniprot
proteins
mass_dalton
115121
uniprot
proteins
mutagenesis
MUTAGEN 232; /note="L->R: Abolishes interaction with Ccdc42."; /evidence="ECO:0000269|PubMed:38038747"; MUTAGEN 245; /note="Y->D: Abolishes interaction with Ccdc42."; /evidence="ECO:0000269|PubMed:38038747"; MUTAGEN 541; /note="D->R: Abolishes interaction with Ccdc38."; /evidence="ECO:0000269|PubMed:38038747"; MUTAGEN 547; /note="R->D: Abolishes interaction with Ccdc38."; /evidence="ECO:0000269|PubMed:38038747
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
38038747
uniprot
proteins
pubmed
38441556
uniprot
proteins
sequence_length
977
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q8IYE0}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:38038747, ECO:0000269|PubMed:38441556}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:38441556}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q8IYE0}. Midbody {ECO:0000250|UniProtKB:Q8IYE0}. Note=Localizes to the sperm connecting piece and flagellum during spermiogenesis and to the flagellum in spermatozoa from cauda of the epididymis (PubMed:38038747). In sperm cell flagellum, may be associated with tubulin doublets (PubMed:38441556). {ECO:0000250|UniProtKB:Q8IYE0, ECO:0000269|PubMed:38038747, ECO:0000269|PubMed:38441556}.
uniprot
proteins