Six1
entrez
20471
canonical
uniprot
Q62231
canonical
ensembl
ENSMUSG00000051367
resolver
ensp
ENSMUSP00000059026
resolver
enst
ENSMUST00000050029
resolver
genesymbol
Six1
resolver
uniprot
Q3V2C3
resolver
uniprot
Q8BSP4
resolver
uniprot
Q8CIL7
resolver
uniprot_entry
Q3V2C3_MOUSE
resolver
uniprot_entry
Q8BSP4_MOUSE
resolver
uniprot_entry
SIX1_MOUSE
resolver
uniprot_sec
Q8CIL7
resolver
amino_acid_sequence
MSMLPSFGFTQEQVACVCEVLQQGGNLERLGRFLWSLPACDHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSYCFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENTENNNSSSNKQNQLSPLEGGKPLMSSSEEEFSPPQSPDQNSVLLLQSNMGHARSSNYSLPGLTASQPSHGLQAHQHQLQDSLLGPLTSSLVDLGS
uniprot
proteins
function
FUNCTION: Transcription factor that is involved in the regulation of cell proliferation, apoptosis and embryonic development (PubMed:12215533, PubMed:12668636, PubMed:12834866, PubMed:14628042, PubMed:14695375). Plays an important role in the development of several organs, including kidney, muscle and inner ear (PubMed:12668636, PubMed:12783782, PubMed:12834866, PubMed:14628042, PubMed:14695375). Depending on context, functions as a transcriptional repressor or activator (PubMed:14628042). Lacks an activation domain, and requires interaction with EYA family members for transcription activation (By similarity). Mediates nuclear translocation of EYA1 and EYA2 (By similarity). Binds the 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the MYOG promoter and CIDEA enhancer (By similarity). Regulates the expression of numerous genes, including MYC, CCNA1, CCND1 and EZR (PubMed:16488997). Acts as an activator of the IGFBP5 promoter, probably coactivated by EYA2 (PubMed:11978764). Repression of precursor cell proliferation in myoblasts is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex (PubMed:14628042). During myogenesis, seems to act together with EYA2 and DACH2. Regulates the expression of CCNA1 (By similarity). Promotes brown adipocyte differentiation (PubMed:27923061). {ECO:0000250|UniProtKB:Q15475, ECO:0000269|PubMed:11978764, ECO:0000269|PubMed:12215533, ECO:0000269|PubMed:12668636, ECO:0000269|PubMed:12783782, ECO:0000269|PubMed:12834866, ECO:0000269|PubMed:14628042, ECO:0000269|PubMed:14695375, ECO:0000269|PubMed:16488997, ECO:0000269|PubMed:27923061}.
uniprot
proteins
mass_dalton
32210
uniprot
proteins
post_translational_modification
PTM: Phosphorylated during interphase; becomes hyperphosphorylated during mitosis. Hyperphosphorylation impairs binding to promoter elements (By similarity). {ECO:0000250}.; PTM: Ubiquitinated by the anaphase promoting complex (APC), leading to its proteasomal degradation. {ECO:0000250}.
uniprot
proteins
protein_family
SIX/Sine oculis homeobox family
uniprot
proteins
pubmed
11978764
uniprot
proteins
pubmed
12215533
uniprot
proteins
pubmed
12668636
uniprot
proteins
pubmed
12783782
uniprot
proteins
pubmed
12834866
uniprot
proteins
pubmed
14628042
uniprot
proteins
pubmed
14695375
uniprot
proteins
pubmed
15141091
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16488997
uniprot
proteins
pubmed
21884692
uniprot
proteins
pubmed
27923061
uniprot
proteins
pubmed
7720577
uniprot
proteins
pubmed
9826681
uniprot
proteins
sequence_length
284
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q15475}. Cytoplasm {ECO:0000250|UniProtKB:Q15475}.
uniprot
proteins