Lair1
entrez
574531
canonical
uniprot
P0C1X9
canonical
ensembl
ENSRNOG00000027733
resolver
ensembl
ENSRNOG00055016311
resolver
ensembl
ENSRNOG00060028153
resolver
ensp
ENSRNOP00000037815
resolver
ensp
ENSRNOP00055022202
resolver
ensp
ENSRNOP00060040888
resolver
enst
ENSRNOT00000036413
resolver
enst
ENSRNOT00055027667
resolver
enst
ENSRNOT00060048999
resolver
genesymbol
Lair1
resolver
uniprot_entry
LAIR1_RAT
resolver
amino_acid_sequence
MPLHSVIVLVLVLCLGWKSNTQEESLSDFTICAEPGPVIPQGNFITIVCSTSGEYDTVRLEKEGSTFMEKKTEPHGKQHRFRIGPVNETITGYYNCIFEKNYVWSQRSNDLQLKVIKENVTQGLAPGPSMTSDTSWLKTYSIHILTVVSVIFLLCLSLFLFCFLSHRQKKQGLPNNKSQHQRSQERLNLATNGLEKTSDIVMDDSLSEDRQTETWTPVAGDLQEVTYAQLDHDSLTQRTVKDVTPQNRVIMAESSTYAAIMRC
uniprot
proteins
function
FUNCTION: Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Also down-regulates IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
29724
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Tyr-227 and Tyr-257 activates it. May be phosphorylated by LCK (By similarity). {ECO:0000250}.; PTM: N-glycosylated. {ECO:0000250}.
uniprot
proteins
pubmed
15902436
uniprot
proteins
sequence_length
263
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 144..164; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins