IL5RA
entrez
3568
canonical
uniprot
Q01344
canonical
ensembl
ENSG00000091181
resolver
ensp
ENSP00000256452
resolver
ensp
ENSP00000309196
resolver
ensp
ENSP00000373358
resolver
ensp
ENSP00000390753
resolver
ensp
ENSP00000392059
resolver
ensp
ENSP00000400400
resolver
ensp
ENSP00000412209
resolver
genesymbol
IL5RA
resolver
genesymbol_syn
IL5R
resolver
hgnc
HGNC:6017
resolver
uniprot
B3IU77
resolver
uniprot
B4E2G0
resolver
uniprot
Q14633
resolver
uniprot
Q15469
resolver
uniprot
Q6ISX9
resolver
uniprot
Q8NHV7
resolver
uniprot_entry
IL5RA_HUMAN
resolver
uniprot_entry
Q8NHV7_HUMAN
resolver
uniprot_sec
B3IU77
resolver
uniprot_sec
B4E2G0
resolver
uniprot_sec
Q14633
resolver
uniprot_sec
Q15469
resolver
uniprot_sec
Q6ISX9
resolver
amino_acid_sequence
MIIVAHVLLILLGATEILQADLLPDEKISLLPPVNFTIKVTGLAQVLLQWKPNPDQEQRNVNLEYQVKINAPKEDDYETRITESKCVTILHKGFSASVRTILQNDHSLLASSWASAELHAPPGSPGTSIVNLTCTTNTTEDNYSRLRSYQVSLHCTWLVGTDAPEDTQYFLYYRYGSWTEECQEYSKDTLGRNIACWFPRTFILSKGRDWLAVLVNGSSKHSAIRPFDQLFALHAIDQINPPLNVTAEIEGTRLSIQWEKPVSAFPIHCFDYEVKIHNTRNGYLQIEKLMTNAFISIIDDLSKYDVQVRAAVSSMCREAGLWSEWSQPIYVGNDEHKPLREWFVIVIMATICFILLILSLICKICHLWIKLFPPIPAPKSNIKDLFVTTNYEKAGSSETEIEVICYIEKPGVETLEDSVF
uniprot
proteins
function
FUNCTION: Cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:9378992). Acts by forming a heterodimeric receptor with CSF2RB subunit and subsequently binding to interleukin-5 (PubMed:1495999, PubMed:22528658). In unstimulated conditions, interacts constitutively with JAK2. Heterodimeric receptor activation leads to JAK2 stimulation and subsequent activation of the JAK-STAT pathway (PubMed:9516124). {ECO:0000269|PubMed:1495999, ECO:0000269|PubMed:22528658, ECO:0000269|PubMed:9378992, ECO:0000269|PubMed:9516124}.
uniprot
proteins
mass_dalton
47685
uniprot
proteins
protein_family
Type 5 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
12842047
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
1495999
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
1732409
uniprot
proteins
pubmed
1833065
uniprot
proteins
pubmed
22153509
uniprot
proteins
pubmed
22528658
uniprot
proteins
pubmed
9378992
uniprot
proteins
pubmed
9516124
uniprot
proteins
sequence_length
420
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 343..362; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins