NOL9
entrez
79707
canonical
uniprot
Q5SY16
canonical
ensembl
ENSG00000162408
resolver
ensp
ENSP00000366934
resolver
enst
ENST00000377705
resolver
genesymbol
NOL9
resolver
hgnc
HGNC:26265
resolver
uniprot
Q2NL84
resolver
uniprot
Q4VBY3
resolver
uniprot
Q6P472
resolver
uniprot
Q7L4D6
resolver
uniprot
Q96EE0
resolver
uniprot
Q9H5L4
resolver
uniprot_entry
NOL9_HUMAN
resolver
uniprot_sec
Q2NL84
resolver
uniprot_sec
Q4VBY3
resolver
uniprot_sec
Q6P472
resolver
uniprot_sec
Q7L4D6
resolver
uniprot_sec
Q96EE0
resolver
uniprot_sec
Q9H5L4
resolver
amino_acid_sequence
MADSGLLLKRGSCRSTWLRVRKARPQLILSRRPRRRLGSLRWCGRRRLRWRLLQAQASGVDWREGARQVSRAAAARRPNTATPSPIPSPTPASEPESEPELESASSCHRPLLIPPVRPVGPGRALLLLPVEQGFTFSGICRVTCLYGQVQVFGFTISQGQPAQDIFSVYTHSCLSIHALHYSQPEKSKKELKREARNLLKSHLNLDDRRWSMQNFSPQCSIVLLEHLKTATVNFITSYPGSSYIFVQESPTPQIKPEYLALRSVGIRREKKRKGLQLTESTLSALEELVNVSCEEVDGCPVILVCGSQDVGKSTFNRYLINHLLNSLPCVDYLECDLGQTEFTPPGCISLLNITEPVLGPPFTHLRTPQKMVYYGKPSCKNNYENYIDIVKYVFSAYKRESPLIVNTMGWVSDQGLLLLIDLIRLLSPSHVVQFRSDHSKYMPDLTPQYVDDMDGLYTKSKTKMRNRRFRLAAFADALEFADEEKESPVEFTGHKLIGVYTDFAFRITPRNRESHNKILRDLSILSYLSQLQPPMPKPLSPLHSLTPYQVPFNAVALRITHSDVAPTHILYAVNASWVGLCKIQDDVRGYTNGPILLAQTPICDCLGFGICRGIDMEKRLYHILTPVPPEELRTVNCLLVGAIAIPHCVLKCQRGIEGTVPYVTTDYNFKLPGASEKIGAREPEEAHKEKPYRRPKFCRKMK
uniprot
proteins
ec_number
2.7.1.78
uniprot
proteins
function
FUNCTION: Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of single-stranded and double-stranded RNA and DNA substrates (PubMed:21063389). Involved in rRNA processing and its kinase activity is required for the processing of the 32S precursor into 5.8S and 28S rRNAs, more specifically for the generation of the major 5.8S(S) form (PubMed:21063389). Required for the efficient pre-rRNA processing of internal transcribed spacer 2 (ITS2) (PubMed:21063389). Associates with LAS1L to form an ITS2 pre-rRNA endonuclease-kinase complex and is responsible for the transport of this complex into the nucleolus (PubMed:31288032). {ECO:0000269|PubMed:21063389, ECO:0000269|PubMed:31288032}.
uniprot
proteins
mass_dalton
79323
uniprot
proteins
mutagenesis
MUTAGEN 312; /note="K->A: Abolishes kinase activity and rRNA processing."; /evidence="ECO:0000269|PubMed:21063389"; MUTAGEN 313; /note="S->A: Abolishes kinase activity and rRNA processing."; /evidence="ECO:0000269|PubMed:21063389
uniprot
proteins
protein_family
Clp1 family
uniprot
proteins
protein_family
NOL9/GRC3 subfamily
uniprot
proteins
pubmed
12429849
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21063389
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
31288032
uniprot
proteins
sequence_length
702
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q3TZX8}. Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:21063389, ECO:0000269|PubMed:31288032}. Note=Colocalizes with pre-60S rRNP particles.
uniprot
proteins