Smurf2
entrez
66313
canonical
uniprot
A2A5Z6
canonical
ensembl
ENSMUSG00000018363
resolver
ensp
ENSMUSP00000090177
resolver
ensp
ENSMUSP00000099356
resolver
ensp
ENSMUSP00000322919
resolver
genesymbol
Smurf2
resolver
uniprot
A2A5Z7
resolver
uniprot
Q5IRE6
resolver
uniprot
Q9CSE3
resolver
uniprot_entry
Q9CSE3_MOUSE
resolver
uniprot_entry
SMUF2_MOUSE
resolver
uniprot_sec
A2A5Z7
resolver
uniprot_sec
Q5IRE6
resolver
activity_regulation
ACTIVITY REGULATION: Activated by NDFIP1- and NDFIP2-binding. {ECO:0000250|UniProtKB:Q9HAU4}.
uniprot
proteins
amino_acid_sequence
MSNPGGRRNGPVKLRLTVLCAKNLVKKDFFRLPDPFAKVVVDGSGQCHSTDTVKNTLDPKWNQHYDLYIGKSDSVTISVWNHKKIHKKQGAGFLGCVRLLSNAINRLKDTGYQRLDLCKLGPNDNDTVRGQIVVSLQSRDRIGTGGQVVDCSRLFDNDLPDGWEERRTASGRIQYLNHITRTTQWERPTRPASEYSSPGRPLSCFVDENTPITGTNGATCGHSSDPRLAERRVRSQRHRNYMSRTHLHTPPDLPEGYEQRTTQQGQVYFLHTQTGVSTWHDPRVPRDLSNINCEELGPLPPGWEIRNTATGRVYFVDHNNRTTQFTDPRLSANLHLVLNRQNQLKDQQQQQVVPLCPDDTECLTVPRYKRDLVQKLKILRQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAVFHGHYIDGGFTLPFYKQLLGKSITLDDMELVDPDLHNSLVWILENDITGVLDHTFCVEHNAYGEIIQHELKPNGKSIPVTEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVSDWKVNTRLKHCTPDSNVVKWFWKAVEFFDEERRARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAVE
uniprot
proteins
ec_number
2.3.2.26
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (PubMed:24925320). Interacts with SMAD7 to trigger SMAD7-mediated transforming growth factor beta/TGF-beta receptor ubiquitin-dependent degradation, thereby down-regulating TGF-beta signaling (By similarity). In addition, interaction with SMAD7 activates autocatalytic degradation, which is prevented by interaction with AIMP1 (By similarity). Also forms a stable complex with TGF-beta receptor-mediated phosphorylated SMAD1, SMAD2 and SMAD3, and targets SMAD1 and SMAD2 for ubiquitination and proteasome-mediated degradation (By similarity). SMAD2 may recruit substrates, such as SNON, for ubiquitin-dependent degradation (By similarity). Negatively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation (By similarity). Acts as an activator of ferroptosis by mediating ubiquitination and degradation of GSTP1, thereby preventing detoxification of 4-hydroxynonenal (4-HNE) reactive aldehyde (By similarity). Acts as a positive regulator of smoothened signaling pathway by mediating ubiquitination of PTCH1, leading to endocytosis and lysosomal degradation of PTCH1 (PubMed:24925320). {ECO:0000250|UniProtKB:Q9HAU4, ECO:0000269|PubMed:24925320}.
uniprot
proteins
mass_dalton
86175
uniprot
proteins
mutagenesis
MUTAGEN 716; /note="C->G: Abolished E3 ubiquitin-protein ligase activity and ability to ubiquitinate PTCH1."; /evidence="ECO:0000269|PubMed:24925320
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:24925320}.
uniprot
proteins
post_translational_modification
PTM: Auto-ubiquitinated and ubiquitinated in the presence of RNF11 and UBE2D1 (By similarity). Ubiquitinated by the SCF(FBXL15) complex and TTC3, leading to its degradation by the proteasome (By similarity). 'Lys-48'-linked polyubiquitination mediated by TRAF4 at Lys-119 leads to SMURF2 proteasomal degradation (By similarity). {ECO:0000250|UniProtKB:Q9HAU4}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15820682
uniprot
proteins
pubmed
16373342
uniprot
proteins
pubmed
18448069
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
24925320
uniprot
proteins
sequence_length
748
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9HAU4}. Cytoplasm {ECO:0000250|UniProtKB:Q9HAU4}. Cell membrane {ECO:0000250|UniProtKB:Q9HAU4}. Membrane raft {ECO:0000250|UniProtKB:Q9HAU4}. Note=Cytoplasmic in the presence of SMAD7. Colocalizes with CAV1, SMAD7 and TGF-beta receptor in membrane rafts. {ECO:0000250|UniProtKB:Q9HAU4}.
uniprot
proteins