Pthlh
entrez
24695
canonical
uniprot
P13085
canonical
ensembl
ENSRNOG00000069267
resolver
ensembl
ENSRNOG00055009727
resolver
ensembl
ENSRNOG00060000917
resolver
ensembl
ENSRNOG00065006029
resolver
ensp
ENSRNOP00000078983
resolver
ensp
ENSRNOP00055013261
resolver
ensp
ENSRNOP00060000480
resolver
ensp
ENSRNOP00065006503
resolver
enst
ENSRNOT00055016465
resolver
enst
ENSRNOT00060001193
resolver
enst
ENSRNOT00065009114
resolver
genesymbol
Pthlh
resolver
genesymbol_syn
Pthrp
resolver
uniprot_entry
PTHR_RAT
resolver
amino_acid_sequence
MLRRLVQQWSVLVFLLSYSVPSRGRSVEGLGRRLKRAVSEHQLLHDKGKSIQDLRRRFFLHHLIAEIHTAEIRATSEVSPNSKPAPNTKNHPVRFGSDDEGRYLTQETNKVETYKEQPLKTPGKKKKGKPGKRREQEKKKRRTRSAWPGTTGSGLLEDPQPHTSPTSTSLEPSSRTH
uniprot
proteins
function
FUNCTION: Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport (PubMed:3175653). Acts by binding to its receptor, PTH1R, activating G protein-coupled receptor signaling (By similarity). Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth (By similarity). Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs (By similarity). Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). {ECO:0000250|UniProtKB:P12272, ECO:0000250|UniProtKB:P22858, ECO:0000269|PubMed:3175653}.; FUNCTION: [Osteostatin]: Potent inhibitor of osteoclastic bone resorption. {ECO:0000250|UniProtKB:P12272}.
uniprot
proteins
mass_dalton
20204
uniprot
proteins
post_translational_modification
PTM: There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions (By similarity). {ECO:0000250|UniProtKB:P12272}.
uniprot
proteins
protein_family
Parathyroid hormone family
uniprot
proteins
pubmed
2342478
uniprot
proteins
pubmed
2747658
uniprot
proteins
pubmed
3175653
uniprot
proteins
sequence_length
177
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P12272}. Cytoplasm {ECO:0000250|UniProtKB:P12272}. Nucleus {ECO:0000250|UniProtKB:P12272}.
uniprot
proteins