Nubp1
entrez
26425
canonical
uniprot
Q9R060
canonical
ensembl
ENSMUSG00000022503
resolver
ensp
ENSMUSP00000023146
resolver
enst
ENSMUST00000023146
resolver
genesymbol
Nubp1
resolver
uniprot
Q3U053
resolver
uniprot
Q7TMI1
resolver
uniprot
Q9CRM5
resolver
uniprot_entry
NUBP1_MOUSE
resolver
uniprot_sec
Q3U053
resolver
uniprot_sec
Q7TMI1
resolver
uniprot_sec
Q9CRM5
resolver
amino_acid_sequence
MEEAPHGCPGADSAQAGRGASCQGCPNQRLCASGAGAAPDPAVEEIREKMKTVRHKLLVLSGKGGVGKSTFSAHLAHGLAEDGDTQVALLDIDICGPSIPKIMGLEGEQVHQSGSGWSPVYVDDNLGVMSVGFLLSSPDDAVIWRGPKKNGMIKQFLRDVDWGDVDYLIVDTPPGTSDEHLSVVQYLAAAHIDGAVILTTPQEVALQDVRKEISFCHKVKLPIIGVVENMSGFICPKCKKESQIFPPTTGGAEAMCQDLRIPLLGKVPLDPHIGKSCDKGQSFFVEAPDSPATAAYRSIIQRIRDFCNSHQSHAETLISP
uniprot
proteins
function
FUNCTION: Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins (By similarity). Implicated in the regulation of centrosome duplication (PubMed:16638812, PubMed:23807208). Negatively regulates cilium formation and structure (PubMed:23807208). {ECO:0000255|HAMAP-Rule:MF_03038, ECO:0000269|PubMed:16638812, ECO:0000269|PubMed:23807208}.
uniprot
proteins
mass_dalton
34085
uniprot
proteins
protein_family
Mrp/NBP35 ATP-binding proteins family
uniprot
proteins
protein_family
NUBP1/NBP35 subfamily
uniprot
proteins
pubmed
10486206
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16638812
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23807208
uniprot
proteins
sequence_length
320
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03038, ECO:0000269|PubMed:23807208}. Nucleus {ECO:0000269|PubMed:23807208}. Cell projection {ECO:0000269|PubMed:23807208}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:23807208}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:23807208}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:23807208}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:23807208}. Note=Enriched in centrioles of microtubule asters during prophase, prometaphase and telophase stages of mitosis. Localized at centrioles and in the nucleus at interphase. Colocalizes with NUBP2 at prometaphase. Specifically localizes to the axenome of motile cilia as opposed to primary non-motile cilia. Localization is independent of NUBP2 and KIFC1. {ECO:0000269|PubMed:23807208}.
uniprot
proteins