Myo1g
entrez
246177
canonical
uniprot
Q5SUA5
canonical
ensembl
ENSMUSG00000020437
resolver
ensp
ENSMUSP00000003459
resolver
enst
ENSMUST00000003459
resolver
genesymbol
Myo1g
resolver
uniprot
Q8BIT8
resolver
uniprot
Q8BJ17
resolver
uniprot
Q8BJ65
resolver
uniprot
Q8R019
resolver
uniprot
Q91ZI1
resolver
uniprot_entry
MYO1G_MOUSE
resolver
uniprot_sec
Q8BIT8
resolver
uniprot_sec
Q8BJ17
resolver
uniprot_sec
Q8BJ65
resolver
uniprot_sec
Q8R019
resolver
uniprot_sec
Q91ZI1
resolver
amino_acid_sequence
MLAVGRMEDEEGPEYGKPDFVLLDQLTMEDFMKNLELRFEKGRIYTYIGEVLVSVNPYQELPLYGPEAIAKYQGRELYERPPHLYAVANAAYKAMKRRSRDTCIVISGESGAGKTEASKHIMQYIAAVTNPSQRAEVERVKNVLLKSTCVLEAFGNARTNRNHNSSRFGKYMDINFDFKGDPVGGHIHSYLLEKSRVLKQHVGERNFHAFYQLLRGSEDQELQGLHLERNPAVYNFTRQGAGLNMGVHNALDSDEKSHQGVMEAMRIIGFSPDEVESIHRILAAILHLGNIEFVETEENGPQKGGLEVADEALVGYVAKLTATPRDLVLRTLLARTVASGGREVIEKSHTVAEASYARDACAKAMYQRLFEWVVNKINSIMEPRNRDPRCDGKDTVIGVLDIYGFEVFPVNSFEQFCINYCNEKLQQLFIQLILKQEQEEYEREGIAWQTIEYFNNATIVELVEQPHRGILAVLDEACSTAGPITDRIFLQTLDTHHRHHPHYSSRQLCPTDKTMEFGRDFQIKHYAGDVTYSVEGFIDKNRDSLFQDFKRLLYNSVDPTLRAMWPDGQQDITEVTKRPLTAGTLFKNSMVALVENLASKEPFYVRCIKPNEDKVAGRLDEAHCRHQVEYLGLLENVRVRRAGFASRQPYPRFLLRYKMTCEYTWPNHLLGSDRDAVSALLEQHGLQGDVAFGHSKLFIRSPRTLVTLEQSRARLIPIIVLLLQKAWRGTLARWHCRRLRAIYTIMRWFRRHKVRAHLIELQRRFQAARQPPLYGRDLVWPTPPAVLQPFQDTCRVLFSRWRARQLVKNIPPSDMIQIKAKVAAMGALQGLRQDWGCQRAWARDYLSSDTDNPTASHLFAEQLKALREKDGFGSVLFSSHVRKVNRFRKSRDRALLLTDRYLYKLEPGRQYRVMRAVPLEAVTGLSVTSGRDQLVVLHAQGYDDLVVCLHRSQPPLDNRIGELVGMLAAHCQGEGRTLEVRVSDCIPLSQRGARRLISVEPRPEQPEPDFQSSRSTFTLLWPSH
uniprot
proteins
function
FUNCTION: Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration (PubMed:25083865). Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication (PubMed:25083865). Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes (PubMed:24310084). Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis (PubMed:23038771). {ECO:0000269|PubMed:23038771, ECO:0000269|PubMed:24310084, ECO:0000269|PubMed:25083865}.
uniprot
proteins
mass_dalton
117227
uniprot
proteins
mutagenesis
MUTAGEN 111; /note="G->R: Does not affect localization to the plasma membrane."; /evidence="ECO:0000269|PubMed:19968988"; MUTAGEN 167; /note="R->C: Does not affect localization to the plasma membrane."; /evidence="ECO:0000269|PubMed:19968988"; MUTAGEN 883; /note="K->A: Abolishes localization to phagocytic cups; when associated with A-893."; /evidence="ECO:0000269|PubMed:23038771"; MUTAGEN 893; /note="R->A: Abolishes localization to phagocytic cups; when associated with A-883."; /evidence="ECO:0000269|PubMed:23038771
uniprot
proteins
protein_family
Myosin family
uniprot
proteins
protein_family
TRAFAC class myosin-kinesin ATPase superfamily
uniprot
proteins
pubmed
12486594
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19968988
uniprot
proteins
pubmed
20071333
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23038771
uniprot
proteins
pubmed
24310084
uniprot
proteins
pubmed
25083865
uniprot
proteins
sequence_length
1024
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19968988, ECO:0000269|PubMed:20071333, ECO:0000269|PubMed:24310084, ECO:0000269|PubMed:25083865}; Peripheral membrane protein {ECO:0000269|PubMed:19968988, ECO:0000269|PubMed:20071333, ECO:0000269|PubMed:24310084, ECO:0000269|PubMed:25083865}. Cell projection, phagocytic cup {ECO:0000269|PubMed:23038771}. Note=Recruited to Fc-gamma receptor (Fc-gamma-R) phagocytic cup (PubMed:23038771). In T-cells, transiently accumulates in discrete areas at the plasma membrane of migrating cells or when membranes are deformed (PubMed:25083865). {ECO:0000269|PubMed:23038771, ECO:0000269|PubMed:25083865}.
uniprot
proteins