RITA1
entrez
84934
canonical
uniprot
Q96K30
canonical
ensembl
ENSG00000139405
resolver
ensp
ENSP00000448680
resolver
ensp
ENSP00000449841
resolver
genesymbol
RITA1
resolver
genesymbol_syn
C12orf52
resolver
genesymbol_syn
RITA
resolver
hgnc
HGNC:25925
resolver
uniprot
B3KVZ4
resolver
uniprot
C9JIN1
resolver
uniprot
F8VRG5
resolver
uniprot
Q53GM3
resolver
uniprot
Q96K25
resolver
uniprot_entry
RITA1_HUMAN
resolver
uniprot_sec
B3KVZ4
resolver
uniprot_sec
C9JIN1
resolver
uniprot_sec
F8VRG5
resolver
uniprot_sec
Q53GM3
resolver
uniprot_sec
Q96K25
resolver
amino_acid_sequence
MKTPVELAVSGMQTLGLQHRCRGGYRVKARTSYVDETLFGSPAGTRPTPPDFDPPWVEKANRTRGVGKEASKALGAKGSCETTPSRGSTPTLTPRKKNKYRPISHTPSYCDESLFGSRSEGASFGAPRMAKGDAAKLRALLWTPPPTPRGSHSPRPREAPLRAIHPAGPSKTEPGPAADSQKLSMGGLHSSRPLKRGLSHSLTHLNVPSTGHPATSAPHTNGPQDLRPSTSGVTFRSPLVTSRARSVSISVPSTPRRGGATQKPKPPWK
uniprot
proteins
function
FUNCTION: Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of RBPJ/RBPSUH, thereby preventing the interaction between RBPJ/RBPSUH and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis. {ECO:0000269|PubMed:21102556}.
uniprot
proteins
mass_dalton
28619
uniprot
proteins
mutagenesis
MUTAGEN 7; /note="L->A: Results in nuclear accumulation; when associated with A-12 and A-15."; /evidence="ECO:0000269|PubMed:21102556"; MUTAGEN 12; /note="M->A: Results in nuclear accumulation; when associated with A-7 and A-15."; /evidence="ECO:0000269|PubMed:21102556"; MUTAGEN 15; /note="L->A: Results in nuclear accumulation; when associated with A-7 and A-12."; /evidence="ECO:0000269|PubMed:21102556"; MUTAGEN 95..97; /note="RKK->AAA: Abolishes nuclear localization."; /evidence="ECO:0000269|PubMed:21102556
uniprot
proteins
protein_family
RITA family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
21102556
uniprot
proteins
sequence_length
269
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21102556}. Nucleus {ECO:0000269|PubMed:21102556}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:21102556}. Note=Shuttles rapidly between the cytoplasm and the nucleus. The function of centrosome localization is still unclear.
uniprot
proteins