Hnf4a
entrez
15378
canonical
uniprot
P49698
canonical
ensembl
ENSMUSG00000017950
resolver
ensp
ENSMUSP00000018094
resolver
ensp
ENSMUSP00000298912
resolver
genesymbol
Hnf4a
resolver
genesymbol_syn
Hnf-4
resolver
genesymbol_syn
Hnf4
resolver
genesymbol_syn
Hnf4alpha
resolver
genesymbol_syn
Nr2a1
resolver
genesymbol_syn
Tcf14
resolver
uniprot
A2A5I5
resolver
uniprot
A2ICH0
resolver
uniprot
B9VVT5
resolver
uniprot
B9VVT6
resolver
uniprot
Q3UNX3
resolver
uniprot
Q8CFY1
resolver
uniprot_entry
B9VVT5_MOUSE
resolver
uniprot_entry
B9VVT6_MOUSE
resolver
uniprot_entry
HNF4A_MOUSE
resolver
uniprot_sec
A2A5I5
resolver
uniprot_sec
A2ICH0
resolver
uniprot_sec
Q3UNX3
resolver
uniprot_sec
Q8CFY1
resolver
amino_acid_sequence
MRLSKTLAGMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGANLNSSNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSQQITSPISGINGDIRAKKIANITDVCESMKEQLLVLVEWAKYIPAFCELLLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYACLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSASDAPHTHHPLHPHLMQEHMGTNVIVANTMPSHLSNGQMCEWPRPRGQAATPETPQPSPPSGSGSESYKLLPGAITTIVKPPSAIPQPTITKQEAI
uniprot
proteins
function
FUNCTION: Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitatating the recruitment of RNA pol II to the promoters of target genes (By similarity). Activates the transcription of CYP2C38 (PubMed:30555544). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698). {ECO:0000250|UniProtKB:P41235, ECO:0000269|PubMed:30530698, ECO:0000269|PubMed:30555544}.
uniprot
proteins
mass_dalton
52684
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residue(s); phosphorylation is important for its DNA-binding activity. Phosphorylation may directly or indirectly play a regulatory role in the subnuclear distribution. Phosphorylation at Ser-313 by AMPK reduces the ability to form homodimers and bind DNA (By similarity). {ECO:0000250}.; PTM: Acetylation at Lys-458 lowers transcriptional activation by about two-fold. {ECO:0000250}.
uniprot
proteins
protein_family
NR2 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16670015
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17407387
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20159955
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28751364
uniprot
proteins
pubmed
30530698
uniprot
proteins
pubmed
30555544
uniprot
proteins
pubmed
7999795
uniprot
proteins
sequence_length
474
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins