RCVRN
entrez
5957
canonical
uniprot
P35243
canonical
ensembl
ENSG00000109047
resolver
ensp
ENSP00000226193
resolver
enst
ENST00000226193
resolver
genesymbol
RCVRN
resolver
genesymbol_syn
RCV1
resolver
hgnc
HGNC:9937
resolver
uniprot
Q53XL0
resolver
uniprot_entry
RECO_HUMAN
resolver
uniprot_sec
Q53XL0
resolver
amino_acid_sequence
MGNSKSGALSKEILEELQLNTKFSEEELCSWYQSFLKDCPTGRITQQQFQSIYAKFFPDTDPKAYAQHVFRSFDSNLDGTLDFKEYVIALHMTTAGKTNQKLEWAFSLYDVDGNGTISKNEVLEIVMAIFKMITPEDVKLLPDDENTPEKRAEKIWKYFGKNDDDKLTEKEFIEGTLANKEILRLIQFEPQKVKEKMKNA
uniprot
proteins
function
FUNCTION: Acts as a calcium sensor and regulates phototransduction of cone and rod photoreceptor cells (By similarity). Modulates light sensitivity of cone photoreceptor in dark and dim conditions (By similarity). In response to high Ca(2+) levels induced by low light levels, prolongs RHO/rhodopsin activation in rod photoreceptor cells by binding to and inhibiting GRK1-mediated phosphorylation of RHO/rhodopsin (By similarity). Plays a role in scotopic vision/enhances vision in dim light by enhancing signal transfer between rod photoreceptors and rod bipolar cells (By similarity). Improves rod photoreceptor sensitivity in dim light and mediates response of rod photoreceptors to facilitate detection of change and motion in bright light (By similarity). {ECO:0000250|UniProtKB:P21457, ECO:0000250|UniProtKB:P34057}.
uniprot
proteins
mass_dalton
23130
uniprot
proteins
post_translational_modification
PTM: The N-terminal glycine is linked to one of four different types of acyl groups. The most abundant is myristoleate (14:1), but 14:0, 14:2, and 12:0 acyl residues are also present (By similarity). The Ca(2+) induced exposure of the myristoyl group, known as the calcium-myristoyl switch, promotes RCVRN binding to the photoreceptor cell membranes only when intracellular Ca(2+) concentration is high (By similarity). {ECO:0000250|UniProtKB:P21457}.; PTM: Oxidation on Cys-39 occurs in response to prolonged intense illumination and results in the formation of disulfide homodimers, and to a lesser extent disulfide-linked heterodimers. {ECO:0000250|UniProtKB:P21457}.
uniprot
proteins
protein_family
Recoverin family
uniprot
proteins
pubmed
1387789
uniprot
proteins
pubmed
1388144
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1999465
uniprot
proteins
pubmed
21697133
uniprot
proteins
pubmed
8500558
uniprot
proteins
pubmed
8912538
uniprot
proteins
sequence_length
200
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Photoreceptor inner segment {ECO:0000250|UniProtKB:P34057}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:P34057}. Photoreceptor outer segment membrane {ECO:0000250|UniProtKB:P21457}; Lipid-anchor {ECO:0000250|UniProtKB:P21457}; Cytoplasmic side {ECO:0000250|UniProtKB:P21457}. Perikaryon {ECO:0000250|UniProtKB:P34057}. Note=Primarily expressed in the inner segments of light-adapted rod photoreceptors, approximately 10% of which translocates from photoreceptor outer segments upon light stimulation (By similarity). Targeting of myristoylated protein to rod photoreceptor outer segments is calcium dependent (By similarity). {ECO:0000250|UniProtKB:P21457, ECO:0000250|UniProtKB:P34057}.
uniprot
proteins