S1PR2
entrez
9294
canonical
uniprot
O95136
canonical
ensembl
ENSG00000267534
resolver
ensp
ENSP00000496438
resolver
enst
ENST00000646641
resolver
genesymbol
S1PR2
resolver
genesymbol_syn
EDG5
resolver
hgnc
HGNC:3169
resolver
uniprot
Q86UN8
resolver
uniprot_entry
S1PR2_HUMAN
resolver
uniprot_sec
Q86UN8
resolver
amino_acid_sequence
MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV
uniprot
proteins
disease_involvement
DISEASE: Deafness, autosomal recessive, 68 (DFNB68) [MIM:610419]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269|PubMed:26805784}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P) (PubMed:10617617, PubMed:25274307). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues (PubMed:10617617). When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis (PubMed:10617617). Receptor for the chemokine-like protein FAM19A5 (PubMed:29453251). Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration (By similarity). In lymphoid follicles, couples the binding of S1P to the activation of GNA13 and downstream inhibition of AKT activation leading to suppression of germinal center (GC) B cell growth and migration outside the GC niche. {ECO:0000250|UniProtKB:P47752, ECO:0000269|PubMed:10617617, ECO:0000269|PubMed:25274307, ECO:0000269|PubMed:29453251}.
uniprot
proteins
mass_dalton
38867
uniprot
proteins
mutagenesis
MUTAGEN 147; /note="R->C: No effect on protein expression at the cell surface. Decreases S1PR2-mediated inhibition of AKT activation and B cell migration. Loss of S1PR2-dependent inhibition of GCB cell growth."; /evidence="ECO:0000269|PubMed:25274307"; MUTAGEN 156; /note="W->G: Loss of protein expression."; /evidence="ECO:0000269|PubMed:25274307"; MUTAGEN 194; /note="V->E: Loss of protein expression."; /evidence="ECO:0000269|PubMed:25274307"; MUTAGEN 245; /note="C->R: Markedly decreases protein expression."; /evidence="ECO:0000269|PubMed:25274307"; MUTAGEN 248; /note="P->S: Loss of protein expression."; /evidence="ECO:0000269|PubMed:25274307"; MUTAGEN 256; /note="D->E: Loss of protein expression."; /evidence="ECO:0000269|PubMed:25274307"; MUTAGEN 272; /note="Y->N: Decreases protein expression. No effect on S1P-mediated inhibition of AKT signaling, GCB cell growth and migration."; /evidence="ECO:0000269|PubMed:25274307"; MUTAGEN 329; /note="R->C: No effect on protein expression or S1PR2-mediated inhibition of AKT activation and B cell migration."; /evidence="ECO:0000269|PubMed:25274307
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10617617
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
25274307
uniprot
proteins
pubmed
26805784
uniprot
proteins
pubmed
29453251
uniprot
proteins
sequence_length
353
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25274307}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 35..59; /note="Helical; Name=1"; /evidence="ECO:0000250"; TRANSMEM 67..95; /note="Helical; Name=2"; /evidence="ECO:0000250"; TRANSMEM 110..128; /note="Helical; Name=3"; /evidence="ECO:0000250"; TRANSMEM 148..173; /note="Helical; Name=4"; /evidence="ECO:0000250"; TRANSMEM 190..210; /note="Helical; Name=5"; /evidence="ECO:0000250"; TRANSMEM 234..255; /note="Helical; Name=6"; /evidence="ECO:0000250"; TRANSMEM 272..292; /note="Helical; Name=7"; /evidence="ECO:0000250
uniprot
proteins