TMEM95
entrez
339168
canonical
uniprot
Q3KNT9
canonical
ensembl
ENSG00000182896
resolver
ensembl
ENSG00000288511
resolver
ensp
ENSP00000331466
resolver
ensp
ENSP00000374632
resolver
ensp
ENSP00000460828
resolver
genesymbol
TMEM95
resolver
hgnc
HGNC:27898
resolver
uniprot
B7WPI7
resolver
uniprot
Q6UXT3
resolver
uniprot
Q8IW68
resolver
uniprot_entry
TMM95_HUMAN
resolver
uniprot_sec
B7WPI7
resolver
uniprot_sec
Q6UXT3
resolver
uniprot_sec
Q8IW68
resolver
amino_acid_sequence
MWRLALGGVFLAAAQACVFCRLPAHDLSGRLARLCSQMEARQKECGASPDFSAFALDEVSMNKVTEKTHRVLRVMEIKEAVSSLPSYWSWLRKTKLPEYTREALCPPACRGSTTLYNCSTCKGTEVSCWPRKRCFPGSQDLWEAKILLLSIFGAFLLLGVLSLLVESHHLQAKSGL
uniprot
proteins
function
FUNCTION: Sperm protein required for fusion of sperm with the egg membrane during fertilization. {ECO:0000269|PubMed:36161911}.
uniprot
proteins
mass_dalton
19597
uniprot
proteins
mutagenesis
MUTAGEN 70; /note="R->A: Significant loss of sperm-binding to hamster egg membrane."; /evidence="ECO:0000269|PubMed:36161911"; MUTAGEN 73; /note="R->A: Significant loss of sperm-binding to hamster egg membrane."; /evidence="ECO:0000269|PubMed:36161911
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:36161911}.
uniprot
proteins
protein_family
TMEM95 family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
36161911
uniprot
proteins
sequence_length
176
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:P0DJF3}; Single-pass type I membrane protein {ECO:0000305}. Note=Following the acrosome reaction, relocalizes to the equatorial segment. {ECO:0000250|UniProtKB:P0DJF3}.
uniprot
proteins
transmembrane_region
TRANSMEM 146..166; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins