LGALS1
entrez
3956
canonical
uniprot
P09382
canonical
ensembl
ENSG00000100097
resolver
ensp
ENSP00000215909
resolver
enst
ENST00000215909
resolver
genesymbol
LGALS1
resolver
hgnc
HGNC:6561
resolver
uniprot
A0A384MR27
resolver
uniprot
B2R5E8
resolver
uniprot
Q9UDK5
resolver
uniprot_entry
A0A384MR27_HUMAN
resolver
uniprot_entry
LEG1_HUMAN
resolver
uniprot_sec
B2R5E8
resolver
uniprot_sec
Q9UDK5
resolver
amino_acid_sequence
MACGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD
uniprot
proteins
function
FUNCTION: Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. Plays a negative role in Th17 cell differentiation via activation of the receptor CD69 (PubMed:24752896). {ECO:0000269|PubMed:14617626, ECO:0000269|PubMed:18796645, ECO:0000269|PubMed:19497882, ECO:0000269|PubMed:24752896, ECO:0000269|PubMed:24945728}.
uniprot
proteins
mass_dalton
14716
uniprot
proteins
pubmed
10369126
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
10764829
uniprot
proteins
pubmed
11146440
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
12761501
uniprot
proteins
pubmed
1386213
uniprot
proteins
pubmed
14617626
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15476813
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18796645
uniprot
proteins
pubmed
18824694
uniprot
proteins
pubmed
19128029
uniprot
proteins
pubmed
19497882
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
1988031
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
22905912
uniprot
proteins
pubmed
23131994
uniprot
proteins
pubmed
2383549
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24752896
uniprot
proteins
pubmed
24945728
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26091039
uniprot
proteins
pubmed
2719646
uniprot
proteins
pubmed
2719964
uniprot
proteins
pubmed
2910856
uniprot
proteins
pubmed
3065332
uniprot
proteins
pubmed
32272059
uniprot
proteins
pubmed
3611046
uniprot
proteins
pubmed
7501023
uniprot
proteins
sequence_length
135
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:14617626}. Cytoplasm {ECO:0000269|PubMed:32272059}. Secreted {ECO:0000269|PubMed:32272059}. Note=Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. {ECO:0000269|PubMed:32272059}.
uniprot
proteins