Mbp
entrez
17196
canonical
uniprot
P04370
canonical
ensembl
ENSMUSG00000041607
resolver
ensp
ENSMUSP00000046185
resolver
ensp
ENSMUSP00000089393
resolver
ensp
ENSMUSP00000114230
resolver
ensp
ENSMUSP00000114630
resolver
ensp
ENSMUSP00000115082
resolver
ensp
ENSMUSP00000115409
resolver
ensp
ENSMUSP00000116019
resolver
ensp
ENSMUSP00000121855
resolver
ensp
ENSMUSP00000257300
resolver
genesymbol
Mbp
resolver
genesymbol_syn
Shi
resolver
uniprot
Q01585
resolver
uniprot
Q03139
resolver
uniprot
Q03176
resolver
uniprot
Q3UGF3
resolver
uniprot
Q542T4
resolver
uniprot
Q5D096
resolver
uniprot
Q61836
resolver
uniprot
Q61837
resolver
uniprot
Q99KE4
resolver
uniprot
Q9QWP1
resolver
uniprot_entry
MBP_MOUSE
resolver
uniprot_entry
Q3UGF3_MOUSE
resolver
uniprot_entry
Q542T4_MOUSE
resolver
uniprot_entry
Q5D096_MOUSE
resolver
uniprot_sec
Q01585
resolver
uniprot_sec
Q03139
resolver
uniprot_sec
Q03176
resolver
uniprot_sec
Q61836
resolver
uniprot_sec
Q61837
resolver
uniprot_sec
Q99KE4
resolver
uniprot_sec
Q9QWP1
resolver
amino_acid_sequence
MGNHSGKRELSAEKASKDGEIHRGEAGKKRSVGKLSQTASEDSDVFGEADAIQNNGTSAEDTAVTDSKHTADPKNNWQGAHPADPGNRPHLIRLFSRDAPGREDNTFKDRPSESDELQTIQEDPTAASGGLDVMASQKRPSQRSKYLATASTMDHARHGFLPRHRDTGILDSIGRFFSGDRGAPKRGSGKDSHTRTTHYGSLPQKSQHGRTQDENPVVHFFKNIVTPRTPPPSQGKGGRDSRSGSPMARR
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Mbp are a cause of dysmyelinating diseases such as the shiverer (SHI) and myelin deficient (MLD) diseases characterized by decreased myelination in the CNS, tremors, and convulsions of progressively increasing severity leading to early death. The shiverer mice only express isoform 2, the MLD mice have a reduced amount of Mbp.
uniprot
proteins
function
FUNCTION: The classic group of MBP isoforms (isoform 4-isoform 13) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined to optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. {ECO:0000269|PubMed:11145205}.
uniprot
proteins
mass_dalton
27168
uniprot
proteins
post_translational_modification
PTM: As in other animals, several charge isomers may be produced as a result of optional post-translational modifications, such as phosphorylation of serine or threonine residues, deamidation of glutamine or asparagine residues, citrullination and methylation of arginine residues.; PTM: Methylated on arginine residues; decreases with the age of the animal, making MBP more cationic.; PTM: Phosphorylated by TAOK2, VRK2, MAPK11, MAPK12, MAPK14 and MINK1. {ECO:0000250}.; PTM: Proteolytically cleaved in B cell lysosomes by cathepsin CTSG which degrades the major immunogenic MBP epitope and prevents the activation of MBP-specific autoreactive T cells. {ECO:0000250|UniProtKB:P02686}.
uniprot
proteins
protein_family
Myelin basic protein family
uniprot
proteins
pubmed
11145205
uniprot
proteins
pubmed
1279125
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15648052
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
1692584
uniprot
proteins
pubmed
1705957
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2410136
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
2416470
uniprot
proteins
pubmed
2425357
uniprot
proteins
pubmed
2433693
uniprot
proteins
pubmed
2452084
uniprot
proteins
pubmed
2470651
uniprot
proteins
pubmed
6198644
uniprot
proteins
pubmed
7680345
uniprot
proteins
pubmed
7681106
uniprot
proteins
pubmed
9736652
uniprot
proteins
sequence_length
250
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 13]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.; SUBCELLULAR LOCATION: [Isoform 12]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.; SUBCELLULAR LOCATION: [Isoform 11]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.; SUBCELLULAR LOCATION: [Isoform 10]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.; SUBCELLULAR LOCATION: [Isoform 9]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.; SUBCELLULAR LOCATION: [Isoform 8]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.; SUBCELLULAR LOCATION: [Isoform 7]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.; SUBCELLULAR LOCATION: [Isoform 6]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.; SUBCELLULAR LOCATION: [Isoform 5]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.; SUBCELLULAR LOCATION: [Isoform 4]: Myelin membrane; Peripheral membrane protein; Cytoplasmic side.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Nucleus.
uniprot
proteins