Lrrc8c
entrez
100604
canonical
uniprot
Q8R502
canonical
ensembl
ENSMUSG00000054720
resolver
ensp
ENSMUSP00000066015
resolver
ensp
ENSMUSP00000258293
resolver
enst
ENSMUST00000067924
resolver
genesymbol
Lrrc8c
resolver
genesymbol_syn
Ad158
resolver
genesymbol_syn
Fad158
resolver
uniprot
Q3TEP9
resolver
uniprot
Q8C296
resolver
uniprot
Q8R0N7
resolver
uniprot
Q8R3G5
resolver
uniprot_entry
LRC8C_MOUSE
resolver
uniprot_sec
Q3TEP9
resolver
uniprot_sec
Q8C296
resolver
uniprot_sec
Q8R0N7
resolver
uniprot_sec
Q8R3G5
resolver
amino_acid_sequence
MIPVTEFRQFSEQQPAFRVLKPWWDVFTDYLSVAMLMIGVFGCTLQVMQDKIICLPKRVQPAQNHSSVPNVSQAVISTTPLPPPKPSPTNPATVEMKGLKTDLDLQQYSFINQMCYERALHWYAKYFPYLVLIHTLVFMLCSNFWFKFPGSSSKIEHFISILGKCFDSPWTTRALSEVSGEDSEEKDNRKNNMNRSGTIQSGPEGNLVRSQSLKSIPEKFVVDKSAAGALDKKEGEQAKALFEKVKKFRLHVEEGDILYAMYVRQTVLKVIKFLIIIAYNSALVSKVQFTVDCNVDIQDMTGYKNFSCNHTMAHLFSKLSFCYLCFVSIYGLTCLYTLYWLFYRSLREYSFEYVRQETGIDDIPDVKNDFAFMLHMIDQYDPLYSKRFAVFLSEVSENKLKQLNLNNEWTPDKLRQKLQTNAHNRLELPLIMLSGLPDTVFEITELQSLKLEIIKNVMIPATIAQLDNLQELCLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLVGSLSHDISKNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCVHNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWYNSIAYIPEHIKKLTSLERLFFSHNKVEVLPSHLFLCNKIRYLDLSYNDIRFIPPEIGVLQSLQYFSITCNKVESLPDELYFCKKLKTLKIGKNSLSVLSPKIGNLLFLSYLDIKGNHFEVLPPELGDCRALKRAGLVVEDALFETLPSDVREQMKAD
uniprot
proteins
function
FUNCTION: Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:29769723, PubMed:36522427, PubMed:36928458). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (By similarity). Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress (By similarity). The VRAC channel also mediates transport of immunoreactive cyclic dinucleotide GMP-AMP (2'-3'-cGAMP), an immune messenger produced in response to DNA virus in the cytosol (By similarity). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:36522427, PubMed:36928458). May play a role in adipogenesis (PubMed:15184384, PubMed:15564382, PubMed:21804215). {ECO:0000250|UniProtKB:Q8TDW0, ECO:0000269|PubMed:15184384, ECO:0000269|PubMed:15564382, ECO:0000269|PubMed:21804215, ECO:0000269|PubMed:29769723, ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458}.
uniprot
proteins
mass_dalton
92372
uniprot
proteins
mutagenesis
MUTAGEN 105; /note="L->R: No effect on channel activity of the complex with LRRC8A."; /evidence="ECO:0000269|PubMed:29769723
uniprot
proteins
protein_family
LRRC8 family
uniprot
proteins
pubmed
15184384
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15564382
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21804215
uniprot
proteins
pubmed
24782309
uniprot
proteins
pubmed
29769723
uniprot
proteins
pubmed
36522427
uniprot
proteins
pubmed
36928458
uniprot
proteins
sequence_length
803
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29769723}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TDW0}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8TDW0}. Note=In the absence of LRRC8A, resides primarily in a cytoplasmic compartment, probably the endoplasmic reticulum. Requires LRRC8A for expression at the cell membrane. {ECO:0000250|UniProtKB:Q8TDW0}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..48; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK"; TRANSMEM 125..144; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK"; TRANSMEM 263..284; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK"; TRANSMEM 315..339; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:36522427, ECO:0000269|PubMed:36928458, ECO:0007744|PDB:8B40, ECO:0007744|PDB:8DRK
uniprot
proteins