RTF2
entrez
51507
canonical
uniprot
Q9BY42
canonical
ensembl
ENSG00000022277
resolver
ensp
ENSP00000023939
resolver
ensp
ENSP00000349906
resolver
ensp
ENSP00000379220
resolver
ensp
ENSP00000556993
resolver
enst
ENST00000023939
resolver
enst
ENST00000357348
resolver
enst
ENST00000395881
resolver
genesymbol
RTF2
resolver
genesymbol_syn
C20orf43
resolver
genesymbol_syn
RTFDC1
resolver
hgnc
HGNC:15890
resolver
uniprot
A0A0A0MQR2
resolver
uniprot
A2A2L6
resolver
uniprot
B4DXL5
resolver
uniprot
E1P5Z9
resolver
uniprot
Q9BYL7
resolver
uniprot
Q9HCV9
resolver
uniprot
Q9NX29
resolver
uniprot
Q9NZZ8
resolver
uniprot
Q9P002
resolver
uniprot
Q9UHW3
resolver
uniprot_entry
A0A0A0MQR2_HUMAN
resolver
uniprot_entry
A2A2L6_HUMAN
resolver
uniprot_entry
B4DXL5_HUMAN
resolver
uniprot_entry
RTF2_HUMAN
resolver
uniprot_sec
E1P5Z9
resolver
uniprot_sec
Q9BYL7
resolver
uniprot_sec
Q9HCV9
resolver
uniprot_sec
Q9NX29
resolver
uniprot_sec
Q9NZZ8
resolver
uniprot_sec
Q9P002
resolver
uniprot_sec
Q9UHW3
resolver
amino_acid_sequence
MGCDGGTIPKRHELVKGPKKVEKVDKDAELVAQWNYCTLSQEILRRPIVACELGRLYNKDAVIEFLLDKSAEKALGKAASHIKSIKNVTELKLSDNPAWEGDKGNTKGDKHDDLQRARFICPVVGLEMNGRHRFCFLRCCGCVFSERALKEIKAEVCHTCGAAFQEDDVIMLNGTKEDVDVLKTRMEERRLRAKLEKKTKKPKAAESVSKPDVSEEAPGPSKVKTGKPEEASLDSREKKTNLAPKSTAMNESSSGKAGKPPCGATKRSIADSEESEAYKSLFTTHSSAKRSKEESAHWVTHTSYCF
uniprot
proteins
function
FUNCTION: Replication termination factor which is a component of the elongating replisome (Probable). Required for ATR pathway signaling upon DNA damage and has a positive activity during DNA replication. Might function to facilitate fork pausing at replication fork barriers like the rDNA. May be globally required to stimulate ATR signaling after the fork stalls or encounters a lesion (Probable). Interacts with nascent DNA (PubMed:29290612). {ECO:0000269|PubMed:29290612, ECO:0000305|PubMed:29290612}.
uniprot
proteins
mass_dalton
33887
uniprot
proteins
post_translational_modification
PTM: Undergoes proteasomal degradation, via DDI1 and DDI2. Removal from stalled replisomes and degradation are required for genome stability. {ECO:0000269|PubMed:29290612}.
uniprot
proteins
protein_family
Rtf2 family
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
29290612
uniprot
proteins
sequence_length
306
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:29290612}. Note=Localizes at the replication fork. {ECO:0000269|PubMed:29290612}.
uniprot
proteins