CCR2
entrez
729230
canonical
uniprot
P41597
canonical
ensembl
ENSG00000121807
resolver
ensp
ENSP00000383681
resolver
ensp
ENSP00000399285
resolver
genesymbol
CCR2
resolver
genesymbol_syn
CMKBR2
resolver
hgnc
HGNC:1603
resolver
uniprot
A0AVQ3
resolver
uniprot
B2RMT0
resolver
uniprot
O95950
resolver
uniprot
Q4VBL2
resolver
uniprot_entry
CCR2_HUMAN
resolver
uniprot_sec
A0AVQ3
resolver
uniprot_sec
B2RMT0
resolver
uniprot_sec
O95950
resolver
uniprot_sec
Q4VBL2
resolver
amino_acid_sequence
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
uniprot
proteins
disease_involvement
DISEASE: Polycystic lung disease (PCLUD) [MIM:219600]: An autosomal recessive disease characterized by pulmonary alveolar proteinosis, marked peribronchovascular and parenchymal lymphocytosis, peribronchiolar pulmonary fibrosis, progressive diffuse parenchymal lung cyst formation and enlargement, progressive obstructive airflow limitation, and recurrent secondary infections. Additional features may include digital clubbing, allergies, and atopic dermatitis. {ECO:0000269|PubMed:38157855}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Key functional receptor for CCL2 but can also bind CCL7, and CCL12 (PubMed:23408426, PubMed:38157855, PubMed:8048929, PubMed:8146186). Also transduces signaling mediated by CCL13 (PubMed:38157855). Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (PubMed:38157855). Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B (PubMed:23938203). Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation (By similarity). Facilitates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression; signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B (By similarity). Mediates the recruitment of macrophages and monocytes to the injury site following brain injury (By similarity). {ECO:0000250|UniProtKB:P51683, ECO:0000269|PubMed:23408426, ECO:0000269|PubMed:23938203, ECO:0000269|PubMed:38157855, ECO:0000269|PubMed:8048929, ECO:0000269|PubMed:8146186, ECO:0000305|PubMed:15995708}.; FUNCTION: (Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection. {ECO:0000269|PubMed:9789057}.
uniprot
proteins
mass_dalton
41915
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:11046064}.; PTM: Sulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form (PubMed:11046064, PubMed:23408426). Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer (PubMed:11046064, PubMed:23408426). {ECO:0000269|PubMed:11046064, ECO:0000269|PubMed:23408426}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11046064
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15995708
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
18587271
uniprot
proteins
pubmed
23408426
uniprot
proteins
pubmed
23938203
uniprot
proteins
pubmed
25283965
uniprot
proteins
pubmed
27926736
uniprot
proteins
pubmed
35570218
uniprot
proteins
pubmed
38157855
uniprot
proteins
pubmed
8048929
uniprot
proteins
pubmed
8146186
uniprot
proteins
pubmed
8995400
uniprot
proteins
pubmed
9058802
uniprot
proteins
pubmed
9252328
uniprot
proteins
pubmed
9287217
uniprot
proteins
pubmed
9501202
uniprot
proteins
pubmed
9662369
uniprot
proteins
pubmed
9670957
uniprot
proteins
pubmed
9789057
uniprot
proteins
sequence_length
374
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15995708, ECO:0000269|PubMed:18587271, ECO:0000269|PubMed:38157855}; Multi-pass membrane protein {ECO:0000255}. Note=The chemoattractant receptors are distributed throughout the cell surface; after stimulation with a ligand, such as CCL2, they are rapidly recruited into microdomain clusters at the cell membrane. {ECO:0000269|PubMed:15995708}.
uniprot
proteins
transmembrane_region
TRANSMEM 43..70; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 81..100; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 115..136; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 154..178; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 207..226; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 244..268; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 286..309; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins