TRPV2
entrez
51393
canonical
uniprot
Q9Y5S1
canonical
ensembl
ENSG00000187688
resolver
ensp
ENSP00000342222
resolver
ensp
ENSP00000677784
resolver
ensp
ENSP00000677785
resolver
ensp
ENSP00000677786
resolver
ensp
ENSP00000706424
resolver
ensp
ENSP00000706425
resolver
ensp
ENSP00000706426
resolver
ensp
ENSP00000706434
resolver
ensp
ENSP00000706436
resolver
ensp
ENSP00000787069
resolver
ensp
ENSP00000792401
resolver
enst
ENST00000338560
resolver
genesymbol
TRPV2
resolver
genesymbol_syn
VRL
resolver
hgnc
HGNC:18082
resolver
uniprot
A6NML2
resolver
uniprot
A8K0Z0
resolver
uniprot
Q9Y670
resolver
uniprot_entry
TRPV2_HUMAN
resolver
uniprot_sec
A6NML2
resolver
uniprot_sec
A8K0Z0
resolver
uniprot_sec
Q9Y670
resolver
activity_regulation
ACTIVITY REGULATION: Activated by temperatures higher than 52 degrees Celsius (PubMed:10201375). Weakly activated by cannabinoid that binds to the vanilloid binding pocket; this activation is potentiated by the binding of uricosuric agents like probenecid (By similarity). {ECO:0000250|UniProtKB:Q9WUD2, ECO:0000269|PubMed:10201375}.
uniprot
proteins
amino_acid_sequence
MTSPSSSPVFRLETLDGGQEDGSEADRGKLDFGSGLPPMESQFQGEDRKFAPQIRVNLNYRKGTGASQPDPNRFDRDRLFNAVSRGVPEDLAGLPEYLSKTSKYLTDSEYTEGSTGKTCLMKAVLNLKDGVNACILPLLQIDRDSGNPQPLVNAQCTDDYYRGHSALHIAIEKRSLQCVKLLVENGANVHARACGRFFQKGQGTCFYFGELPLSLAACTKQWDVVSYLLENPHQPASLQATDSQGNTVLHALVMISDNSAENIALVTSMYDGLLQAGARLCPTVQLEDIRNLQDLTPLKLAAKEGKIEIFRHILQREFSGLSHLSRKFTEWCYGPVRVSLYDLASVDSCEENSVLEIIAFHCKSPHRHRMVVLEPLNKLLQAKWDLLIPKFFLNFLCNLIYMFIFTAVAYHQPTLKKQAAPHLKAEVGNSMLLTGHILILLGGIYLLVGQLWYFWRRHVFIWISFIDSYFEILFLFQALLTVVSQVLCFLAIEWYLPLLVSALVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLIYLVFLFGFAVALVSLSQEAWRPEAPTGPNATESVQPMEGQEDEGNGAQYRGILEASLELFKFTIGMGELAFQEQLHFRGMVLLLLLAYVLLTYILLLNMLIALMSETVNSVATDSWSIWKLQKAISVLEMENGYWWCRKKQRAGVMLTVGTKPDGSPDERWCFRVEEVNWASWEQTLPTLCEDPSGAGVPRTLENPVLASPPKEDEDGASEENYVPVQLLQSN
uniprot
proteins
function
FUNCTION: Calcium-permeable, non-selective cation channel (PubMed:10201375). Seems to be regulated, at least in part, by growth factors, such as IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce physical stimuli in mast cells (By similarity). {ECO:0000250|UniProtKB:Q9WUD2, ECO:0000269|PubMed:10201375}.
uniprot
proteins
mass_dalton
85981
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q9WUD2}.; PTM: Phosphorylated by PKA. {ECO:0000250|UniProtKB:Q9WUD2}.
uniprot
proteins
protein_family
TRPV2 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
protein_family
TrpV subfamily
uniprot
proteins
pubmed
10201375
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16882997
uniprot
proteins
pubmed
17081065
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
764
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9WTR1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9WUD2}. Cytoplasm {ECO:0000250|UniProtKB:Q9WTR1}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Translocates from the cytoplasm to the plasma membrane upon ligand stimulation (By similarity). Expressed in melanosomes during melanosome maturation from stage I to stage IV. {ECO:0000250|UniProtKB:Q9WTR1}.
uniprot
proteins
transmembrane_region
TRANSMEM 391..409; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q9WUD2"; TRANSMEM 430..452; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q9WUD2"; TRANSMEM 469..487; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q9WUD2"; TRANSMEM 494..514; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q9WUD2"; TRANSMEM 535..556; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q9WUD2"; TRANSMEM 621..641; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q9WUD2
uniprot
proteins