Krt1
entrez
16678
canonical
uniprot
P04104
canonical
ensembl
ENSMUSG00000046834
resolver
ensp
ENSMUSP00000023790
resolver
enst
ENSMUST00000023790
resolver
genesymbol
Krt1
resolver
genesymbol_syn
Krt2-1
resolver
uniprot
Q149E0
resolver
uniprot
Q9D2K8
resolver
uniprot_entry
K2C1_MOUSE
resolver
uniprot_sec
Q149E0
resolver
uniprot_sec
Q9D2K8
resolver
amino_acid_sequence
MSLQCSSRSLCRGGGGSRNFSSGSAGLVSFQRRSTSSSMRRSGGGGGGRFSGGGFCGSSGSGFGSKSLMNLGGGRSISKSVAGGGGSFCGGFGGGSYGGGGFGGGSYGGGGFGGGSFGGGGFGGSGFGGGLGGGGGFGSGGGFGGGRFGSMGPVCPPGGIQEVTINQSLLQPLNVEVDPQIQKVKSQEREQIKSLNDKFASFIDKVRFLEQQNQVLQTKWELLQQVDTTTRTQNLDPFFENYISILRRKVDSLKSDQSRMDSELKNMQDLVEEYRTKYEDEINKRTNAENEFVTIKKDVDSAYMTKVELQAKADALQQDIDFFSALYQMEMSQMQTQISETNVVLSMDNNRSLDLDGIISEVKAQYDSICQRSKAEAETFYQSKYEELQITAGKHGDSVRNTKMEISELNRMIQRLRSEIDGCKKQISQIQQNINDAEQRGEKALKDAQNKLNEIEDALSQCKEDLARLLRDFQELMNTKLALDMEIATYKKLLEGEEIRMSGECTPNVSVSVSTSHTSMSGSSSRGGGSGGGRYGGGGSYGGGSGGGSYGGSSGGGGSGGSYGGGSGGGSYGGGSGGGSSGSHRGGSGGGGGSSGGSYGGSSGGGRGGSSSGGGGVKSSGSSTVKFVSTSYSRGTK
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Krt1 are a cause of epidermolytic hyperkeratosis (EHK); also known as bullous congenital ichthyosiform erythroderma (BIE). EHK is a hereditary skin disorder characterized by intraepidermal blistering, a marked thickening of the stratum corneum, pigmentation of the skin and erosions at sites of trauma which are all present from birth.
uniprot
proteins
function
FUNCTION: Structural component of intermediate filaments in suprabasal keratinocytes of stratified epithelia. Forms heteropolymers with a type I keratin, assembling into keratin intermediate filament networks that provide mechanical strength and structural stability to differentiating epidermal cells. May regulate the activity of kinases such as PKC and SRC by interacting with integrin beta-1 (ITB1) and the receptor of activated protein C kinase 1 (RACK1). In complex with C1QBP, acts as a high-affinity receptor for kininogen-1 (HMWK). {ECO:0000250|UniProtKB:P04264}.
uniprot
proteins
mass_dalton
65606
uniprot
proteins
post_translational_modification
PTM: Undergoes deimination of some arginine residues (citrullination). {ECO:0000269|PubMed:11841545}.
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
11408584
uniprot
proteins
pubmed
11841545
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16528356
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24751727
uniprot
proteins
pubmed
24940650
uniprot
proteins
pubmed
2581964
uniprot
proteins
sequence_length
637
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P04264}. Cytoplasm {ECO:0000250|UniProtKB:P04264}.
uniprot
proteins