Cldn15
entrez
60363
canonical
uniprot
Q9Z0S5
canonical
ensembl
ENSMUSG00000001739
resolver
ensp
ENSMUSP00000001790
resolver
ensp
ENSMUSP00000106722
resolver
enst
ENSMUST00000001790
resolver
enst
ENSMUST00000111093
resolver
genesymbol
Cldn15
resolver
uniprot
Q9D7Z0
resolver
uniprot
Q9D8A6
resolver
uniprot_entry
CLD15_MOUSE
resolver
uniprot_sec
Q9D7Z0
resolver
uniprot_sec
Q9D8A6
resolver
amino_acid_sequence
MSVAVETFGFFMSALGLLMLGLTLSNSYWRVSTVHGNVITTNTIFENLWYSCATDSLGVSNCWDFPSMLALSGYVQGCRALMITAILLGFLGLFLGMVGLRCTNVGNMDLSKKAKLLAIAGTLHILAGACGMVAISWYAVNITTDFFNPLYAGTKYELGPALYLGWSASLLSILGGICVFSTCCCSSKEEPATRAGLPYKPSTVVIPRATSDESDISFGKYGKNAYV
uniprot
proteins
function
FUNCTION: Forms paracellular channels: polymerizes in tight junction strands with cation- and water-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability (PubMed:18242218, PubMed:20727355, PubMed:23089202, PubMed:37100833). In intestinal epithelium, allows for sodium and water fluxes from the peritoneal side to the lumen of the intestine to regulate nutrient absorption and intestinal morphogenesis (PubMed:18242218, PubMed:20727355, PubMed:23089202, PubMed:37100833). {ECO:0000269|PubMed:18242218, ECO:0000269|PubMed:20727355, ECO:0000269|PubMed:23089202, ECO:0000269|PubMed:37100833}.
uniprot
proteins
mass_dalton
24280
uniprot
proteins
mutagenesis
MUTAGEN 68; /note="M->A,E: Abolishes formation of tight-junction strand-like structures."; /evidence="ECO:0000269|PubMed:24744376"; MUTAGEN 68; /note="M->I,L: No effect on formation of tight-junction strand-like structures."; /evidence="ECO:0000269|PubMed:24744376"; MUTAGEN 102; /note="C->A: Abolishes palmitoylation; when associated with 183-A--A-185."; /evidence="ECO:0000269|PubMed:24744376"; MUTAGEN 146..147; /note="FF->AA: Abolishes formation of tight-junction strand-like structures."; /evidence="ECO:0000269|PubMed:24744376"; MUTAGEN 183..185; /note="CCC->AAA: Abolishes palmitoylation; when associated with A-102."; /evidence="ECO:0000269|PubMed:24744376
uniprot
proteins
post_translational_modification
PTM: Palmitoylated when heterogeneously expressed in S.frugiperda cells. {ECO:0000269|PubMed:24744376}.
uniprot
proteins
protein_family
Claudin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16505581
uniprot
proteins
pubmed
18242218
uniprot
proteins
pubmed
20727355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23089202
uniprot
proteins
pubmed
24744376
uniprot
proteins
pubmed
37100833
uniprot
proteins
sequence_length
227
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250|UniProtKB:P56746}. Cell membrane {ECO:0000250|UniProtKB:P56746}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 2..24; /note="Helical"; TRANSMEM 75..99; /note="Helical"; TRANSMEM 116..140; /note="Helical"; TRANSMEM 160..182; /note="Helical
uniprot
proteins