Ascl1
entrez
17172
canonical
uniprot
Q02067
canonical
ensembl
ENSMUSG00000020052
resolver
ensp
ENSMUSP00000020243
resolver
enst
ENSMUST00000020243
resolver
genesymbol
Ascl1
resolver
genesymbol_syn
Ash1
resolver
genesymbol_syn
Mash-1
resolver
genesymbol_syn
Mash1
resolver
uniprot
Q7TNT5
resolver
uniprot_entry
ASCL1_MOUSE
resolver
uniprot_sec
Q7TNT5
resolver
amino_acid_sequence
MESSGKMESGAGQQPQPPQPFLPPAACFFATAAAAAAAAAAAAQSAQQQQPQAPPQQAPQLSPVADSQPSGGGHKSAAKQVKRQRSSSPELMRCKRRLNFSGFGYSLPQQQPAAVARRNERERNRVKLVNLGFATLREHVPNGAANKKMSKVETLRSAVEYIRALQQLLDEHDAVSAAFQAGVLSPTISPNYSNDLNSMAGSPVSSYSSDEGSYDPLSPEEQELLDFTNWF
uniprot
proteins
function
FUNCTION: Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways (PubMed:24243019). Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes (PubMed:20107439, PubMed:24243019, PubMed:27281220). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (PubMed:20107439, PubMed:24243019, PubMed:27281220). Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS (PubMed:8217843). Essential for the generation of olfactory and autonomic neurons (PubMed:8221886). Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation (PubMed:16020526, PubMed:17728344). Involved in the regulation of neuroendocrine cell development in the glandular stomach (PubMed:18173746). {ECO:0000269|PubMed:16020526, ECO:0000269|PubMed:17728344, ECO:0000269|PubMed:18173746, ECO:0000269|PubMed:20107439, ECO:0000269|PubMed:24243019, ECO:0000269|PubMed:27281220, ECO:0000269|PubMed:8217843, ECO:0000269|PubMed:8221886}.
uniprot
proteins
mass_dalton
24741
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1576967
uniprot
proteins
pubmed
16020526
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17728344
uniprot
proteins
pubmed
18173746
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20107439
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
24243019
uniprot
proteins
pubmed
27281220
uniprot
proteins
pubmed
8217843
uniprot
proteins
pubmed
8221886
uniprot
proteins
pubmed
8424959
uniprot
proteins
sequence_length
231
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:1576967}.
uniprot
proteins