Trub1
entrez
72133
canonical
uniprot
Q8C0D0
canonical
ensembl
ENSMUSG00000025086
resolver
ensp
ENSMUSP00000026072
resolver
ensp
ENSMUSP00000026073
resolver
ensp
ENSMUSP00000275253
resolver
genesymbol
Trub1
resolver
uniprot
Q5EBH7
resolver
uniprot
Q9D331
resolver
uniprot_entry
TRUB1_MOUSE
resolver
uniprot_sec
Q5EBH7
resolver
uniprot_sec
Q9D331
resolver
amino_acid_sequence
MAAAEAEVVSPLIVDTAPDTSGTAEASVAASVAEAARTESQAPASKAALAAKLMSLSGVFAVHKPKGPTSAELLNRLKEKLLAEAGMPSPEWNKRQKQTLKVGHGGTLDSAAQGVLVVGIGRGTKMLTSMLSGSKRYITIGELGKATDTLDSTGKVTEEKPYDKITREDIEGILQKFTGNIMQVPPLYSALKKDGQRLSTLMKKGKVVEARPARPVTVHSISLLKFQPPFFTLDVECGGGFYIRSLVSDIGKELSSCASVLELTRTKQGPFTLAQHALPEDRWTIDDIEQSLERCTSLLPEELTFKKLKSDNSSDQVISCGYITLRDTKREDDAVKTL
uniprot
proteins
ec_number
5.4.99.-
uniprot
proteins
ec_number
5.4.99.25
uniprot
proteins
function
FUNCTION: Pseudouridine synthase that catalyzes pseudouridylation of mRNAs and tRNAs. Mediates pseudouridylation of mRNAs with the consensus sequence 5'-GUUCNANNC-3', harboring a stem-loop structure. Constitutes the major pseudouridine synthase acting on mRNAs. Also catalyzes pseudouridylation of some tRNAs, including synthesis of pseudouridine(55) from uracil-55, in the psi GC loop of a subset of tRNAs. Promotes the processing of pri-let-7 microRNAs (pri-miRNAs) independently of its RNA pseudouridylate synthase activity. Acts by binding to the stem-loop structure on pri-let-7, preventing LIN28-binding (LIN28A and/or LIN28B), thereby enhancing the interaction between pri-let-7 and the microprocessor DGCR8, which mediates miRNA maturation. {ECO:0000250|UniProtKB:Q8WWH5}.
uniprot
proteins
mass_dalton
36348
uniprot
proteins
protein_family
Pseudouridine synthase TruB family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
338
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8WWH5}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q8WWH5}. Note=Catalyzes pseudouridylation of mRNAs in the nucleus. {ECO:0000250|UniProtKB:Q8WWH5}.
uniprot
proteins