MAGED1
entrez
9500
canonical
uniprot
Q9Y5V3
canonical
ensembl
ENSG00000179222
resolver
ensp
ENSP00000325333
resolver
ensp
ENSP00000364847
resolver
ensp
ENSP00000364927
resolver
ensp
ENSP00000568322
resolver
ensp
ENSP00000568323
resolver
genesymbol
MAGED1
resolver
genesymbol_syn
NRAGE
resolver
hgnc
HGNC:6813
resolver
uniprot
Q5VSH6
resolver
uniprot
Q8IZ84
resolver
uniprot
Q8WY92
resolver
uniprot
Q9H352
resolver
uniprot
Q9HBT4
resolver
uniprot
Q9UF36
resolver
uniprot_entry
MAGD1_HUMAN
resolver
uniprot_sec
Q5VSH6
resolver
uniprot_sec
Q8IZ84
resolver
uniprot_sec
Q8WY92
resolver
uniprot_sec
Q9H352
resolver
uniprot_sec
Q9HBT4
resolver
uniprot_sec
Q9UF36
resolver
amino_acid_sequence
MAQKMDCGAGLLGFQAEASVEDSALLMQTLMEAIQISEAPPTNQATAAASPQSSQPPTANEMADIQVSAAAARPKSAFKVQNATTKGPNGVYDFSQAHNAKDVPNTQPKAAFKSQNATPKGPNAAYDFSQAATTGELAANKSEMAFKAQNATTKVGPNATYNFSQSLNANDLANSRPKTPFKAWNDTTKAPTADTQTQNVNQAKMATSQADIETDPGISEPDGATAQTSADGSQAQNLESRTIIRGKRTRKINNLNVEENSSGDQRRAPLAAGTWRSAPVPVTTQNPPGAPPNVLWQTPLAWQNPSGWQNQTARQTPPARQSPPARQTPPAWQNPVAWQNPVIWPNPVIWQNPVIWPNPIVWPGPVVWPNPLAWQNPPGWQTPPGWQTPPGWQGPPDWQGPPDWPLPPDWPLPPDWPLPTDWPLPPDWIPADWPIPPDWQNLRPSPNLRPSPNSRASQNPGAAQPRDVALLQERANKLVKYLMLKDYTKVPIKRSEMLRDIIREYTDVYPEIIERACFVLEKKFGIQLKEIDKEEHLYILISTPESLAGILGTTKDTPKLGLLLVILGVIFMNGNRASEAVLWEALRKMGLRPGVRHPLLGDLRKLLTYEFVKQKYLDYRRVPNSNPPEYEFLWGLRSYHETSKMKVLRFIAEVQKRDPRDWTAQFMEAADEALDALDAAAAEAEARAEARTRMGIGDEAVSGPWSWDDIEFELLTWDEEGDFGDPWSRIPFTFWARYHQNARSRFPQTFAGPIIGPGGTASANFAANFGAIGFFWVE
uniprot
proteins
function
FUNCTION: Involved in the apoptotic response after nerve growth factor (NGF) binding in neuronal cells. Inhibits cell cycle progression, and facilitates NGFR-mediated apoptosis. May act as a regulator of the function of DLX family members. May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Plays a role in the circadian rhythm regulation. May act as RORA co-regulator, modulating the expression of core clock genes such as BMAL1 and NFIL3, induced, or NR1D1, repressed. {ECO:0000269|PubMed:20864041}.
uniprot
proteins
mass_dalton
86161
uniprot
proteins
pubmed
10409427
uniprot
proteins
pubmed
10985348
uniprot
proteins
pubmed
11087672
uniprot
proteins
pubmed
11280991
uniprot
proteins
pubmed
15094062
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
20864041
uniprot
proteins
sequence_length
778
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Note=Expression shifts from the cytoplasm to the plasma membrane upon stimulation with NGF. {ECO:0000250}.
uniprot
proteins