Thsd4
entrez
207596
canonical
uniprot
Q3UTY6
canonical
ensembl
ENSMUSG00000032289
resolver
ensp
ENSMUSP00000034829
resolver
ensp
ENSMUSP00000096257
resolver
ensp
ENSMUSP00000131418
resolver
genesymbol
Thsd4
resolver
uniprot
Q8BLE5
resolver
uniprot_entry
THSD4_MOUSE
resolver
uniprot_sec
Q8BLE5
resolver
amino_acid_sequence
MVSYLTSCLSALSTLLLLLGSQLVCPQPSTEHRKVPQRMAVTEGTPEDSGSGSPGVWGSWGPWSACSRSCSGGVMEQTRPCLPSSYRARGGSRPNGRALSITGHVVSAVRTSVPLHRSQEDQRALAGSNASRQGPAVVRGSRHPQARGREPSERRSRTRGPIGPGKYGYGKAPYILPLQTDTTHTPQRLRRQRPSSRHSRSQEASASKQGYRPPTHQFSHSQPLYQSDSGPRSGLPPSEASIYQLPLTHDQSYPAASSLFHRPELSSHHGARPHGAAQAFPQHLRSTAISCIGAYRQYKLCNTNACPESGRSIREVQCASYNNKPFMGRFYEWEPFAEVKGNRKCELNCQATGYRFYVRQAEKVIDGTPCDQNGTAICVSGQCKSIGCDDFLGSDKVLDKCGVCGGDNTGCQVVSGVFKHALTSLGYHRVVEIPQGATKINITEMHKSNNYLALRSRSGRSIINGNWAIDRPGKYEGGGTMFTYKRPNEVSSTAGESFLAEGPTNEILDVYMIHQQPNPGVHYEYVIMRNNAISPQVPPHRRPGEPFNGQLEEEDRGQEDREEREKNQEKEDSQVEAPEVFTSESTQTFPVRHPERFPSHRPDNLVPPAPQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHRNTHEEVPESYCDSSMKPTPEEEPCNLFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDMVHDEECNMKLRPNDIENCDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNNRPVEATPCDNGPCTGKVEWFTGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPYECSFLEKPPSQQACHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTPSSLCDPQLKPEERESCNTQDCVPEVDENCKDKYYNCNVVVQARLCVYNYYKTACCASCTRVANRHVGFLGSR
uniprot
proteins
function
FUNCTION: Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN. {ECO:0000269|PubMed:18757743, ECO:0000269|PubMed:19940141, ECO:0000269|PubMed:21880733}.
uniprot
proteins
mass_dalton
113243
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18757743
uniprot
proteins
pubmed
19940141
uniprot
proteins
pubmed
21880733
uniprot
proteins
sequence_length
1018
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:18757743, ECO:0000269|PubMed:19940141}. Note=Mostly deposited into pericellular fibrillar matrices (PubMed:19940141). Colocalizes with FBN1 (PubMed:19940141). {ECO:0000269|PubMed:19940141}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted {ECO:0000269|PubMed:19940141}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:18757743, ECO:0000269|PubMed:19940141}. Note=Mostly secreted in the extracellular milieu (PubMed:19940141). In the pericellular fibrillar matrix, colocalizes with FBN1 (PubMed:19940141, PubMed:21880733). {ECO:0000269|PubMed:19940141, ECO:0000269|PubMed:21880733}.
uniprot
proteins