Ilk
entrez
16202
canonical
uniprot
O55222
canonical
ensembl
ENSMUSG00000030890
resolver
ensp
ENSMUSP00000033182
resolver
ensp
ENSMUSP00000130341
resolver
enst
ENSMUST00000033182
resolver
enst
ENSMUST00000163389
resolver
genesymbol
Ilk
resolver
genesymbol_syn
ILK1
resolver
genesymbol_syn
ILK2
resolver
uniprot
Q78KK2
resolver
uniprot_entry
ILK_MOUSE
resolver
uniprot_sec
Q78KK2
resolver
amino_acid_sequence
MDDIFTQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARINVMNRGDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLVANGALVSICNKYGEMPVDKAKAPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPRNGTLNKHSGIDFKQLNFLAKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECPRLRIFSHPNVLPVLGACQAPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALDMARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAPAWVAPEALQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPHVCKLMKICMNEDPAKRPKFDMIVPILEKMQDK
uniprot
proteins
function
FUNCTION: Scaffold protein which mediates protein-protein interactions during a range of cellular events including focal adhesion assembly, cell adhesion and cell migration (By similarity). Regulates integrin-mediated signal transduction by contributing to inside-out integrin activation (By similarity). Recruits PARVA and LIMS1/PITCH to form the heterotrimeric IPP (ILK-PINCH-PARVIN) complex which binds to F-actin via the C-terminal tail of LIMS1 and the N-terminal region of PARVA, promoting F-actin filament bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration (By similarity). Binding to PARVA promotes effective assembly of ILK into focal adhesions while PARVA-bound ILK can simultaneously engage integrin-beta cytoplasmic tails to mediate cell adhesion (By similarity). Plays a role with PARVG in promoting the cell adhesion and spreading of leukocytes (By similarity). Acts as an upstream effector of both AKT1/PKB and GSK3 (By similarity). Mediates trafficking of caveolae to the cell surface in an ITGB1-dependent manner by promoting the recruitment of IQGAP1 to the cell cortex which cooperates with its effector DIAPH1 to locally stabilize microtubules and allow stable insertion of caveolae into the plasma membrane (PubMed:20951348). Required for the maintenance of mitotic spindle integrity by promoting phosphorylation of TACC3 by AURKA (By similarity). Associates with chromatin and may act as a negative regulator of transcription when located in the nucleus (By similarity). {ECO:0000250|UniProtKB:Q13418, ECO:0000250|UniProtKB:Q99J82, ECO:0000269|PubMed:20951348}.
uniprot
proteins
mass_dalton
51373
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by PAK1 modulates ILK subcellular location by promoting its nuclear export. {ECO:0000250|UniProtKB:Q13418}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
TKL Ser/Thr protein kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16737959
uniprot
proteins
pubmed
18325335
uniprot
proteins
pubmed
18483218
uniprot
proteins
pubmed
20951348
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
9366252
uniprot
proteins
sequence_length
452
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, focal adhesion {ECO:0000269|PubMed:18325335, ECO:0000269|PubMed:18483218}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250|UniProtKB:Q13418}. Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:Q13418}. Cell projection, lamellipodium {ECO:0000269|PubMed:18325335}. Cytoplasm {ECO:0000250|UniProtKB:Q13418}. Nucleus {ECO:0000250|UniProtKB:Q13418}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q13418}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q13418}.
uniprot
proteins