Blnk
entrez
17060
canonical
uniprot
Q9QUN3
canonical
ensembl
ENSMUSG00000061132
resolver
ensp
ENSMUSP00000057844
resolver
ensp
ENSMUSP00000112473
resolver
enst
ENSMUST00000054769
resolver
enst
ENSMUST00000117695
resolver
genesymbol
Blnk
resolver
genesymbol_syn
Bash
resolver
genesymbol_syn
Ly57
resolver
genesymbol_syn
Slp65
resolver
uniprot
D3YWR2
resolver
uniprot
O88504
resolver
uniprot_entry
BLNK_MOUSE
resolver
uniprot_entry
D3YWR2_MOUSE
resolver
uniprot_sec
O88504
resolver
amino_acid_sequence
MDKLNKITVPASQKLRQLQKMVHDIKNNEGGIMDKIKKLKVKGPPSVPRRDYALDSPADEEEQWSDDFDSDYENPDEHSDSEMYVMPAEETGDDSYEPPPAEQQTRVVHPALPFTRGEYVDNRSSQRHSPPFSKTLPSKPSWPSAKARLASTLPAPNSLQKPQVPPKPKDLLEDEADYVVPVEDNDENYIHPRESSPPPAEKAPMVNRSTKPNSSSKHMSPPGTVAGRNSGVWDSKSSLPAAPSPLPRAGKKPATPLKTTPVPPLPNASNVCEEKPVPAERHRGSSHRQDTVQSPVFPPTQKPVHQKPVPLPRFPEAGSPAADGPFHSFPFNSTFADQEAELLGKPWYAGACDRKSAEEALHRSNKDGSFLIRKSSGHDSKQPYTLVAFFNKRVYNIPVRFIEATKQYALGKKKNGEEYFGSVVEIVNSHQHNPLVLIDSQNNTKDSTRLKYAVKVS
uniprot
proteins
function
FUNCTION: Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis. {ECO:0000269|PubMed:12761551, ECO:0000269|PubMed:18369315, ECO:0000269|PubMed:9705962}.
uniprot
proteins
mass_dalton
50671
uniprot
proteins
mutagenesis
MUTAGEN 52; /note="Y->F: No effect on pre-BCR down-regulation."; /evidence="ECO:0000269|PubMed:12761551"; MUTAGEN 96; /note="Y->F: Fails to induce pre-BCR down-regulation, leading to splenomegaly and leukemia."; /evidence="ECO:0000269|PubMed:12761551"; MUTAGEN 373; /note="R->L: Abolishes binding to CD79A and SYK."; /evidence="ECO:0000269|PubMed:11449366, ECO:0000269|PubMed:18369315
uniprot
proteins
post_translational_modification
PTM: Following BCR activation, phosphorylated on tyrosine residues by SYK and LYN. When phosphorylated, serves as a scaffold to assemble downstream targets of antigen activation, including PLCG1, VAV1, GRB2 and NCK1. Phosphorylation of Tyr-84, Tyr-178 and Tyr-189 facilitates PLCG1 binding. Phosphorylation of Tyr-72 facilitates VAV1 and NCK1 binding. Phosphorylation is required for both Ca(2+) and MAPK signaling pathways (By similarity). Phosphorylation of Tyr-96 is required for the binding of BTK. {ECO:0000250, ECO:0000269|PubMed:9705962}.
uniprot
proteins
pubmed
11449366
uniprot
proteins
pubmed
11859098
uniprot
proteins
pubmed
11909947
uniprot
proteins
pubmed
12761551
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18369315
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21930792
uniprot
proteins
pubmed
28290451
uniprot
proteins
pubmed
9697839
uniprot
proteins
pubmed
9705962
uniprot
proteins
sequence_length
457
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=BCR activation results in the translocation to membrane fraction. {ECO:0000250}.
uniprot
proteins