Slc38a2
entrez
67760
canonical
uniprot
Q8CFE6
canonical
ensembl
ENSMUSG00000022462
resolver
ensp
ENSMUSP00000023099
resolver
ensp
ENSMUSP00000280451
resolver
ensp
ENSMUSP00000342474
resolver
enst
ENSMUST00000023099
resolver
genesymbol
Slc38a2
resolver
genesymbol_syn
Ata2
resolver
genesymbol_syn
Kiaa1382
resolver
genesymbol_syn
Sat2
resolver
genesymbol_syn
Snat2
resolver
uniprot
Q3TEX3
resolver
uniprot
Q6PFR1
resolver
uniprot
Q6ZPS7
resolver
uniprot
Q810U9
resolver
uniprot
Q8CC66
resolver
uniprot
Q8CD21
resolver
uniprot_entry
S38A2_MOUSE
resolver
uniprot_sec
Q3TEX3
resolver
uniprot_sec
Q6PFR1
resolver
uniprot_sec
Q6ZPS7
resolver
uniprot_sec
Q810U9
resolver
uniprot_sec
Q8CC66
resolver
uniprot_sec
Q8CD21
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by N-methyl-D-glucamine. Inhibited by choline. Allosteric regulation of sodium ions binding by pH. {ECO:0000250|UniProtKB:Q9JHE5}.
uniprot
proteins
amino_acid_sequence
MKKTEMGRFNISPDEDSSSYSSNSDFNYSYPTKQAALKSHYADVDPENQNFLLESNLGKKKYETDFHPGTTSFGMSVFNLSNAIVGSGILGLSYAMANTGIALFIILLTFVSIFSLYSVHLLLKTANEGGSLLYEQLGHKAYGLAGKLAASGSITMQNIGAMSSYLFIVKYELPLVIKALMNIEDTNGLWYLNGDYLVLLVSLVLILPLSLLRNLGYLGYTSGLSLLCMIFFLIVVICKKFQIPCPVEAALVANETVNGTFTQAALALAFNSTADDACRPRYFIFNSQTVYAVPILTFSFVCHPAVLPIYEELKSRSRRRMMNVSKISFFAMFLMYLLAALFGYLTFYGHVESELLHTYSEIVGTDILLLVVRLAVLVAVTLTVPVVIFPIRSSVTHLLCPTKEFSWLRHSIITVTILSFTNLLVIFVPTIRDIFGFIGASAAAMLIFILPSAFYIKLVKKEPMRSVQKIGALCFLLSGIVVMIGSMGLIVLDWVHDASAAGGH
uniprot
proteins
function
FUNCTION: Symporter that cotransports neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane (PubMed:34406367). The transport is pH-sensitive, Li(+)-intolerant, electrogenic, driven by the Na(+) electrochemical gradient and cotransports of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier (By similarity). May function in the transport of amino acids in the supply of maternal nutrients to the fetus through the placenta (PubMed:16365304). Maintains a key metabolic glutamine/glutamate balance underpinning retrograde signaling by dendritic release of the neurotransmitter glutamate (By similarity). Transports L-proline in differentiating osteoblasts for the efficient synthesis of proline-enriched proteins and provides proline essential for osteoblast differentiation and bone formation during bone development (PubMed:34406367). {ECO:0000250|UniProtKB:Q9JHE5, ECO:0000269|PubMed:16365304, ECO:0000269|PubMed:34406367}.
uniprot
proteins
mass_dalton
55503
uniprot
proteins
post_translational_modification
PTM: Polyubiquitination by NEDD4L regulates the degradation and the activity of SLC38A2. {ECO:0000269|PubMed:17003038}.
uniprot
proteins
protein_family
Amino acid/polyamine transporter 2 family
uniprot
proteins
pubmed
12971909
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16365304
uniprot
proteins
pubmed
17003038
uniprot
proteins
pubmed
17050538
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
34406367
uniprot
proteins
sequence_length
504
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17003038, ECO:0000269|PubMed:17050538}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9JHE5}. Note=Insulin promotes recruitment to the plasma membrane from a pool localized in the trans-Golgi network or endosomes (PubMed:17050538). Enriched in the somatodendritic compartment of neurons, it is also detected at the axonal shaft but excluded from the nerve terminal (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:Q9JHE5, ECO:0000269|PubMed:17050538}.
uniprot
proteins
transmembrane_region
TRANSMEM 77..96; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9JHE5, ECO:0000255"; TRANSMEM 103..123; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9JHE5, ECO:0000255"; TRANSMEM 159..177; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9JHE5, ECO:0000255"; TRANSMEM 189..209; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9JHE5, ECO:0000255"; TRANSMEM 218..238; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9JHE5, ECO:0000255"; TRANSMEM 290..310; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9JHE5, ECO:0000255"; TRANSMEM 327..347; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 369..389; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 411..431; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 434..454; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9JHE5, ECO:0000255"; TRANSMEM 470..492; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9JHE5, ECO:0000255
uniprot
proteins