DUS1L
entrez
64118
canonical
uniprot
Q6P1R4
canonical
ensembl
ENSG00000169718
resolver
ensp
ENSP00000303515
resolver
ensp
ENSP00000346280
resolver
ensp
ENSP00000579485
resolver
ensp
ENSP00000621044
resolver
ensp
ENSP00000621045
resolver
ensp
ENSP00000621046
resolver
ensp
ENSP00000621049
resolver
ensp
ENSP00000687314
resolver
enst
ENST00000306796
resolver
enst
ENST00000354321
resolver
enst
ENST00000909426
resolver
enst
ENST00000950985
resolver
enst
ENST00000950986
resolver
enst
ENST00000950990
resolver
genesymbol
DUS1L
resolver
genesymbol_syn
DUS1
resolver
hgnc
HGNC:30086
resolver
uniprot
A6NHV4
resolver
uniprot
Q96AI3
resolver
uniprot_entry
DUS1L_HUMAN
resolver
uniprot_sec
A6NHV4
resolver
uniprot_sec
Q96AI3
resolver
amino_acid_sequence
MPKLQGFEFWSRTLRGARHVVAPMVDQSELAWRLLSRRHGAQLCYTPMLHAQVFVRDANYRKENLYCEVCPEDRPLIVQFCANDPEVFVQAALLAQDYCDAIDLNLGCPQMIAKRGHYGAFLQDEWDLLQRMILLAHEKLSVPVTCKIRVFPEIDKTVRYAQMLEKAGCQLLTVHGRTKEQKGPLSGAASWEHIKAVRKAVAIPVFANGNIQCLQDVERCLRDTGVQGVMSAEGNLHNPALFEGRSPAVWELAEEYLDIVREHPCPLSYVRAHLFKLWHHTLQVHQELREELAKVKTLEGIAAVSQELKLRCQEEISRQEGAKPTGDLPFHWICQPYIRPGPREGSKEKAGARSKRALEEEEGGTEVLSKNKQKKQLRNPHKTFDPSLKPKYAKCDQCGNPKGNRCVFSLCRGCCKKRASKETADCPGHGLLFKTKLEKSLAWKEAQPELQEPQPAAPGTPGGFSEVMGSALA
uniprot
proteins
ec_number
1.3.1.88
uniprot
proteins
function
FUNCTION: Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (PubMed:34798057, PubMed:39354220). Specifically modifies U16 and U17 in cytoplasmic tRNAs (PubMed:39354220). Affects the level of some mature tRNA and thereby the total cellular translation (PubMed:39354220). {ECO:0000269|PubMed:34798057, ECO:0000269|PubMed:39354220}.
uniprot
proteins
mass_dalton
53230
uniprot
proteins
mutagenesis
MUTAGEN 108; /note="C->A: Abolishes cell growth."; /evidence="ECO:0000269|PubMed:39354220
uniprot
proteins
protein_family
Dus family
uniprot
proteins
protein_family
Dus1 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
34798057
uniprot
proteins
pubmed
39354220
uniprot
proteins
sequence_length
473
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:39354220}. Nucleus {ECO:0000269|PubMed:39354220}. Note=Predominantly cytoplasmic localization with a minor population localized to the nucleus. {ECO:0000269|PubMed:39354220}.
uniprot
proteins