Fmo1
entrez
25256
canonical
uniprot
P36365
canonical
ensembl
ENSRNOG00000034191
resolver
ensembl
ENSRNOG00055017904
resolver
ensembl
ENSRNOG00060008910
resolver
ensembl
ENSRNOG00065020401
resolver
ensp
ENSRNOP00000044613
resolver
ensp
ENSRNOP00055024372
resolver
ensp
ENSRNOP00060011608
resolver
ensp
ENSRNOP00065027637
resolver
enst
ENSRNOT00000041908
resolver
enst
ENSRNOT00055030312
resolver
enst
ENSRNOT00060014962
resolver
enst
ENSRNOT00065034490
resolver
genesymbol
Fmo1
resolver
genesymbol_syn
Fmo-1
resolver
uniprot
Q6P7Q5
resolver
uniprot_entry
FMO1_RAT
resolver
uniprot_sec
Q6P7Q5
resolver
amino_acid_sequence
MVKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSCDLGGLWRFTEHVEEGRASLYNSVVSNSSKEMSCYSDFPFPEDYPNFVPNSLFLEYLQLYATQFNLLRCIYFNTKVCSITKRPDFAVSGQWEVVTVCQGKQSSDTFDAVMVCTGFLTNPHLPLDSFPGIQTFKGQYFHSRQYKHPDVFKDKRVLVVGMGNSGTDIAVEASHLAKKVFLSTTGGAWVISRVFDSGYPWDMIFMTRFQNMLRNLLPTPVVSWLISKKMNSWFNHVNYGVAPEDRTQLREPVLNDELPGRIITGKVLIKPSIKEVKENSVVFNNTPKEEPIDVIVFATGYSFAFPFLDESIVKVEDGQASLYKYIFPAHLPKPTLAVIGLIKPLGSMIPTGETQARWVVQVLKGATTLPPPSVMMKEVNERKKNKHSGFGLCYCKALQSDYITYIDDLLTSINAKPDLRAMLLTDPRLALSIFFGPCTPYHFRLTGPGKWEGARKAILTQWDRTVNVTKTRTVQETPSTFETLLKLFSFLALLVAVFFIFL
uniprot
proteins
ec_number
1.14.13.148
uniprot
proteins
ec_number
1.14.13.8
uniprot
proteins
function
FUNCTION: Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics (PubMed:8504165). Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes (By similarity). In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine (PubMed:8504165). {ECO:0000250|UniProtKB:Q01740, ECO:0000269|PubMed:8504165}.
uniprot
proteins
mass_dalton
59825
uniprot
proteins
protein_family
FMO family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8504165
uniprot
proteins
pubmed
9094723
uniprot
proteins
sequence_length
532
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:8504165}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 511..531; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins