POLR3G
entrez
10622
canonical
uniprot
O15318
canonical
ensembl
ENSG00000113356
resolver
ensp
ENSP00000382058
resolver
ensp
ENSP00000421637
resolver
ensp
ENSP00000422892
resolver
ensp
ENSP00000498469
resolver
ensp
ENSP00000529083
resolver
ensp
ENSP00000529084
resolver
ensp
ENSP00000529085
resolver
ensp
ENSP00000529086
resolver
ensp
ENSP00000529087
resolver
ensp
ENSP00000529088
resolver
ensp
ENSP00000582771
resolver
ensp
ENSP00000582772
resolver
ensp
ENSP00000582773
resolver
ensp
ENSP00000582774
resolver
ensp
ENSP00000582776
resolver
ensp
ENSP00000582779
resolver
ensp
ENSP00000582780
resolver
ensp
ENSP00000582781
resolver
ensp
ENSP00000582788
resolver
ensp
ENSP00000582789
resolver
ensp
ENSP00000582791
resolver
ensp
ENSP00000629367
resolver
enst
ENST00000399107
resolver
enst
ENST00000504930
resolver
enst
ENST00000651687
resolver
enst
ENST00000859024
resolver
enst
ENST00000859027
resolver
enst
ENST00000859028
resolver
enst
ENST00000859029
resolver
enst
ENST00000912712
resolver
enst
ENST00000912713
resolver
enst
ENST00000912714
resolver
enst
ENST00000912717
resolver
enst
ENST00000912720
resolver
enst
ENST00000912721
resolver
enst
ENST00000912722
resolver
enst
ENST00000912729
resolver
enst
ENST00000912730
resolver
enst
ENST00000912732
resolver
enst
ENST00000959308
resolver
genesymbol
POLR3G
resolver
hgnc
HGNC:30075
resolver
uniprot
A0A7I2R591
resolver
uniprot
A8MTH0
resolver
uniprot_entry
A0A7I2R591_HUMAN
resolver
uniprot_entry
RPC7_HUMAN
resolver
uniprot_sec
A8MTH0
resolver
amino_acid_sequence
MAGNKGRGRAAYTFNIEAVGFSKGEKLPDVVLKPPPLFPDTDYKPVPLKTGEGEEYMLALKQELRETMKRMPYFIETPEERQDIERYSKRYMKVYKEEWIPDWRRLPREMMPRNKCKKAGPKPKKAKDAGKGTPLTNTEDVLKKMEELEKRGDGEKSDEENEEKEGSKEKSKEGDDDDDDDAAEQEEYDEEEQEEENDYINSYFEDGDDFGADSDDNMDEATY
uniprot
proteins
function
FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:20413673, PubMed:33558764, PubMed:34675218, PubMed:35637192). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci (PubMed:20154270, PubMed:20413673, PubMed:35637192). Acts as a long tether that bridges POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer and the mobile stalk of Pol III, coordinating the dynamics of Pol III stalk and clamp modules during the transition from apo to elongation state. Pol III exists as two alternative complexes defined by the mutually exclusive incorporation of subunit POLR3G/RPC7alpha or POLR3GL/RPC7beta. POLR3G/RPC7alpha modulates Pol III transcriptome by specifically enhancing the transcription of snaR-A non-coding RNAs. At resting state, occupies the active site of apo Pol III and keeps Pol III in an autoinhibitory mode, preventing non-specific transcription (PubMed:33558764, PubMed:33558766, PubMed:35637192). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs), induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370). {ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20154270, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:33558766, ECO:0000269|PubMed:34675218, ECO:0000269|PubMed:35637192}.
uniprot
proteins
mass_dalton
25914
uniprot
proteins
protein_family
Eukaryotic RPC7 RNA polymerase subunit family
uniprot
proteins
pubmed
12391170
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19609254
uniprot
proteins
pubmed
19631370
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20154270
uniprot
proteins
pubmed
20413673
uniprot
proteins
pubmed
21358628
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21898682
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24107381
uniprot
proteins
pubmed
26394183
uniprot
proteins
pubmed
27339422
uniprot
proteins
pubmed
28494942
uniprot
proteins
pubmed
33335104
uniprot
proteins
pubmed
33558764
uniprot
proteins
pubmed
33558766
uniprot
proteins
pubmed
33674783
uniprot
proteins
pubmed
34675218
uniprot
proteins
pubmed
35637192
uniprot
proteins
pubmed
9171375
uniprot
proteins
sequence_length
223
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20154270, ECO:0000269|PubMed:21898682, ECO:0000269|PubMed:33335104}. Cytoplasm {ECO:0000250|UniProtKB:Q6NXY9}. Note=Excluded from nucleoli (PubMed:21898682). In zygotes and the 2-cell stage embryos, mainly in the cytoplasm. Starts to localize to the nucleus in the 8-16 cell stage embryo and early blastocysts (By similarity). {ECO:0000250|UniProtKB:Q6NXY9, ECO:0000269|PubMed:21898682}.
uniprot
proteins