Ppp2r5b
entrez
225849
canonical
uniprot
Q6PD28
canonical
ensembl
ENSMUSG00000024777
resolver
ensp
ENSMUSP00000025695
resolver
ensp
ENSMUSP00000302253
resolver
enst
ENSMUST00000025695
resolver
genesymbol
Ppp2r5b
resolver
uniprot
Q3V3S8
resolver
uniprot
Q8R342
resolver
uniprot_entry
2A5B_MOUSE
resolver
uniprot_sec
Q3V3S8
resolver
uniprot_sec
Q8R342
resolver
amino_acid_sequence
METKLPPASTPTSPSSPGLSPVPPPDKVDGFSRRSLRRARPRRSHSSSQFRYQSNQQELTPLPLLKDVPASELHELLSRKLAQCGVMFDFLDCVADLKGKEVKRAALNELVECVGCTRGVLIEPVYPDIIRMISVNIFRTLPPSENPEFDPEEDEPNLEPSWPHLQLVYEFFLRFLESPDFQPSVAKRYVDQKFVLMLLELFDSEDPREREYLKTILHRVYGKFLGLRAYIRKQCNHIFLRFIYELEHFNGVAELLEILGSIINGFALPLKTEHKQFLVRVLIPLHSVKSLSVFHAQLAYCVVQFLEKDATLTEHVIRGLLKYWPKTCTQKEVMFLGEMEEILDVIEPSQFVKIQEPLFKQVARCVSSPHFQVAERALYFWNNEYILSLIEDNCHTVLPAVFGTLYQVSKEHWNQTIVSLIYNVLKTFMEMNGKLFDELTASYKLEKQQEQQKAQERQELWRGLEELRLRRLQGTQGAKEAPVPRPTPQVAASGGQS
uniprot
proteins
function
FUNCTION: As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. {ECO:0000250|UniProtKB:Q15173}.
uniprot
proteins
mass_dalton
57342
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by CUL3-KLHL15 complex; this modification leads to proteasomal degradation. {ECO:0000250|UniProtKB:Q15173}.
uniprot
proteins
protein_family
Phosphatase 2A regulatory subunit B56 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
497
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q15173}.
uniprot
proteins