Timm22
entrez
79463
canonical
uniprot
Q9JKW1
canonical
ensembl
ENSRNOG00000007988
resolver
ensembl
ENSRNOG00055028524
resolver
ensembl
ENSRNOG00060025919
resolver
ensembl
ENSRNOG00065022001
resolver
ensp
ENSRNOP00000010779
resolver
ensp
ENSRNOP00055040619
resolver
ensp
ENSRNOP00060037215
resolver
ensp
ENSRNOP00065030263
resolver
enst
ENSRNOT00000010778
resolver
enst
ENSRNOT00055049363
resolver
enst
ENSRNOT00060044867
resolver
enst
ENSRNOT00065037470
resolver
genesymbol
Timm22
resolver
genesymbol_syn
Tim22
resolver
uniprot_entry
TIM22_RAT
resolver
amino_acid_sequence
MAAAKAGASAPEAAGSAEAPLQYSLLLQHLVGDKRQPRLLEPGSLGGIPSPAKSEEQKMIERAMESCAFKAVLACVGGFVLGGAFGVFTAGIDTNVGFDPKDPYRTPTAREVLKDMGQRGMSYAKNFAIVGAMFSCTECLVESYRGKSDWKNSVISGCITGGAIGFRAGVKAGAIGCGGFAAFSAAIDYYLR
uniprot
proteins
function
FUNCTION: Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). {ECO:0000250|UniProtKB:Q12328}.
uniprot
proteins
mass_dalton
19918
uniprot
proteins
post_translational_modification
PTM: Disulfide bonds promote efficient assembly of the TIM22 complex. {ECO:0000250|UniProtKB:Q9Y584}.
uniprot
proteins
protein_family
Tim17/Tim22/Tim23 family
uniprot
proteins
pubmed
10611480
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
192
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:Q9Y584}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 72..92; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 123..141; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 168..188; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins