Ptpn11
entrez
19247
canonical
uniprot
P35235
canonical
ensembl
ENSMUSG00000043733
resolver
ensp
ENSMUSP00000058757
resolver
ensp
ENSMUSP00000098333
resolver
genesymbol
Ptpn11
resolver
uniprot
Q3TQ84
resolver
uniprot
Q64509
resolver
uniprot
Q6PCL5
resolver
uniprot_entry
PTN11_MOUSE
resolver
uniprot_sec
Q3TQ84
resolver
uniprot_sec
Q64509
resolver
uniprot_sec
Q6PCL5
resolver
amino_acid_sequence
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYDVGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIVDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIKYSLVDQTSGDQSPLPPCTPTPPCAEMREDSARVYENVGLMQQQRSFR
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus (PubMed:11698646, PubMed:14967142). Positively regulates MAPK signal transduction pathway (By similarity). Dephosphorylates GAB1, ARHGAP35 and EGFR (By similarity). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity (By similarity). Dephosphorylates CDC73 (By similarity). Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification (PubMed:29644115). Dephosphorylates tyrosine-phosphorylated NEDD9/CAS-L (By similarity). Acts as an effector of PDCD1-mediated inhibition of T-cell response: recruited by phosphorylated PDCD1, mediating dephosphorylation of key T-cell receptor (TCR) proximal signaling molecules, leading to TCR signaling inhibition (PubMed:11698646). {ECO:0000250|UniProtKB:Q06124, ECO:0000269|PubMed:11698646, ECO:0000269|PubMed:14967142, ECO:0000269|PubMed:29644115}.
uniprot
proteins
mass_dalton
68035
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Tyr-542 and Tyr-580 upon receptor protein tyrosine kinase activation; which creates a binding site for GRB2 and other SH2-containing proteins. Phosphorylated upon activation of the receptor-type kinase FLT3. Phosphorylated by activated PDGFRB (By similarity). Phosphorylated upon activation of the receptor-type kinase PDGFRA. {ECO:0000250, ECO:0000269|PubMed:10080542, ECO:0000269|PubMed:16885344, ECO:0000269|PubMed:8943348}.
uniprot
proteins
protein_family
Non-receptor class 2 subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
10026201
uniprot
proteins
pubmed
10068651
uniprot
proteins
pubmed
10080542
uniprot
proteins
pubmed
10327049
uniprot
proteins
pubmed
10521483
uniprot
proteins
pubmed
10896938
uniprot
proteins
pubmed
11698646
uniprot
proteins
pubmed
12181353
uniprot
proteins
pubmed
14610044
uniprot
proteins
pubmed
14967142
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16684964
uniprot
proteins
pubmed
16885344
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19948503
uniprot
proteins
pubmed
20526344
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23112346
uniprot
proteins
pubmed
23374343
uniprot
proteins
pubmed
29644115
uniprot
proteins
pubmed
7521735
uniprot
proteins
pubmed
7681217
uniprot
proteins
pubmed
8096088
uniprot
proteins
pubmed
8810330
uniprot
proteins
pubmed
8943348
uniprot
proteins
pubmed
9062191
uniprot
proteins
pubmed
9110989
uniprot
proteins
pubmed
9393882
uniprot
proteins
pubmed
9528781
uniprot
proteins
pubmed
9722576
uniprot
proteins
pubmed
9867848
uniprot
proteins
sequence_length
593
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins