Ifnlr1
entrez
242700
canonical
uniprot
Q8CGK5
canonical
ensembl
ENSMUSG00000062157
resolver
ensp
ENSMUSP00000074009
resolver
enst
ENSMUST00000074408
resolver
genesymbol
Ifnlr1
resolver
genesymbol_syn
Il28ra
resolver
uniprot
Q3URN4
resolver
uniprot
Q6PEV1
resolver
uniprot_entry
INLR1_MOUSE
resolver
uniprot_entry
Q3URN4_MOUSE
resolver
uniprot_sec
Q6PEV1
resolver
amino_acid_sequence
MWRADRWAPLLLFLLQSALGRPRLAPPRNVTLFSQNFTVYLTWLPGLGSPPNVTYFVTYQSYIKTGWRPVEHCAGIKALVCPLMCLKKLNLYSKFKGRVQAASAHGRSPRVESRYLEYLFDVELAPPTLVLTQMEKILRVNATYQLPPCMPSLELKYQVEFWKEGLGSKTLFPDTPYGQPVQIPLQQGASRRHCLSARTVYTLIDIKYSQFSEPSCIFLEAPGDKRAVLAMPSLLLLLIAAVAAGVAWKIMKGNPWFQGVKTPRALDFSEYRYPVATFQPSGPEFSDDLILCPQKELTIRNRPAPQVRNPATLQAGPERDSTEDEDEDTDYDDDGDSVQPYLERPLFISEKPRVMEHSETDESGVDSGGPWTSPVGSDGSSAWDSSDRSWSSTGDSSYKDEVGSSSCLDRKEPDQAPCGDWLQEALPCLEFSEDLGTVEEPLKDGLSGWRISGSLSSKRDLAPVEPPVSLQTLTFCWVNNPEGEEEQEDEEEEEEEEEEEDWESEPKGSNAGCWGTSSVQRTEVRGRMLGDYLVR
uniprot
proteins
function
FUNCTION: The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, and reproductive tracts. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. {ECO:0000269|PubMed:18250457, ECO:0000269|PubMed:21518880}.
uniprot
proteins
mass_dalton
59976
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by FBXO45-containing E3 ligase leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q8IU57}.
uniprot
proteins
protein_family
Type II cytokine receptor family
uniprot
proteins
pubmed
12483210
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18250457
uniprot
proteins
pubmed
21518880
uniprot
proteins
sequence_length
535
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 228..248; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins