Cldn1
entrez
65129
canonical
uniprot
P56745
canonical
ensembl
ENSRNOG00000001926
resolver
ensembl
ENSRNOG00055004594
resolver
ensembl
ENSRNOG00060013046
resolver
ensp
ENSRNOP00000002640
resolver
ensp
ENSRNOP00055005439
resolver
ensp
ENSRNOP00060017609
resolver
enst
ENSRNOT00000002640
resolver
enst
ENSRNOT00055007277
resolver
enst
ENSRNOT00060022222
resolver
genesymbol
Cldn1
resolver
uniprot
Q6P6V9
resolver
uniprot_entry
CLD1_RAT
resolver
uniprot_sec
Q6P6V9
resolver
amino_acid_sequence
MANAGLQLLGFILASLGWIGSIVSTALPQWKIYSYAGDNIVTAQAIYEGLWMSCVSQSTGQIQCKVFDSLLNLNSTLQATRALMVIGILLGLIAIFVSTIGMKCMRCLEDDEVQKMWMAVIGGIIFVISGLATLVATAWYGNRIVQEFYDPMTPVNARYEFGQALFTGWAAASLCLLGGALLSCSCPRKTTSYPTPRPYPKPTPSSGKDYV
uniprot
proteins
function
FUNCTION: Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
22843
uniprot
proteins
protein_family
Claudin family
uniprot
proteins
pubmed
11159859
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
211
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000269|PubMed:11159859}. Cell membrane {ECO:0000269|PubMed:11159859}; Multi-pass membrane protein {ECO:0000269|PubMed:11159859}. Basolateral cell membrane {ECO:0000250|UniProtKB:O95832}. Note=Associates with CD81 and the CLDN1-CD81 complex localizes to the basolateral cell membrane. {ECO:0000250|UniProtKB:O95832}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 82..102; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 116..136; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 164..184; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins