RAB12
entrez
201475
canonical
uniprot
Q6IQ22
canonical
ensembl
ENSG00000206418
resolver
ensp
ENSP00000497886
resolver
enst
ENST00000649141
resolver
genesymbol
RAB12
resolver
hgnc
HGNC:31332
resolver
uniprot
A0A3B3ITT1
resolver
uniprot
A6NEF5
resolver
uniprot
Q4KMQ3
resolver
uniprot_entry
A0A3B3ITT1_HUMAN
resolver
uniprot_entry
RAB12_HUMAN
resolver
uniprot_sec
A6NEF5
resolver
uniprot_sec
Q4KMQ3
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) including DENND3 which promote the exchange of bound GDP for free GTP (PubMed:20937701). Regulated by GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity. Inhibited by GDP dissociation inhibitors (GDIs) (Probable). {ECO:0000269|PubMed:20937701, ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MLLPLLRSSCFPSSSPGGGGGSGGGGGGGDPGAESRPAAQLQRGAHGPPGPLQRAEAEPGADPPRAAEAEGAPGPGARSRGAGGGGRRAEREPHACMDPGAALQRRAGGGGGLGAGSPALSGGQGRRRKQPPRPADFKLQVIIIGSRGVGKTSLMERFTDDTFCEACKSTVGVDFKIKTVELRGKKIRLQIWDTAGQERFNSITSAYYRSAKGIILVYDITKKETFDDLPKWMKMIDKYASEDAELLLVGNKLDCETDREITRQQGEKFAQQITGMRFCEASAKDNFNVDEIFLKLVDDILKKMPLDILRNELSNSILSLQPEPEIPPELPPPRPHVRCC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). RAB12 may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy (By similarity). {ECO:0000250|UniProtKB:P35283, ECO:0000250|UniProtKB:P61026}.
uniprot
proteins
mass_dalton
36315
uniprot
proteins
mutagenesis
MUTAGEN 202; /note="S->A: Loss of phosphorylation. No effect on GDI1 and GDI2 binding."; /evidence="ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:29125462"; MUTAGEN 202; /note="S->E: Phosphomimetic mutant. Loss of GDI1, GDI2, CHM and CHML binding."; /evidence="ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:29125462
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Ser-202 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2. {ECO:0000269|PubMed:26824392, ECO:0000269|PubMed:29125462}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20937701
uniprot
proteins
pubmed
21194374
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26824392
uniprot
proteins
pubmed
29125462
uniprot
proteins
sequence_length
340
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000250|UniProtKB:P35283}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Lysosome membrane {ECO:0000250|UniProtKB:P35283}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P51152}. Cytoplasmic vesicle, autophagosome {ECO:0000250|UniProtKB:P35283}.
uniprot
proteins