SEPTIN14
entrez
346288
canonical
uniprot
Q6ZU15
canonical
ensembl
ENSG00000154997
resolver
ensp
ENSP00000373627
resolver
enst
ENST00000388975
resolver
genesymbol
SEPTIN14
resolver
genesymbol_syn
SEPT14
resolver
hgnc
HGNC:33280
resolver
uniprot
A6NCC2
resolver
uniprot
B4DXD6
resolver
uniprot_entry
SEP14_HUMAN
resolver
uniprot_sec
A6NCC2
resolver
uniprot_sec
B4DXD6
resolver
amino_acid_sequence
MAERTMAMPTQIPADGDTQKENNIRCLTTIGHFGFECLPNQLVSRSIRQGFTFNILCVGETGIGKSTLIDTLFNTNLKDNKSSHFYSNVGLQIQTYELQESNVQLKLTVVETVGYGDQIDKEASYQPIVDYIDAQFEAYLQEELKIKRSLFEYHDSRVHVCLYFISPTGHSLKSLDLLTMKNLDSKVNIIPLIAKADTISKNDLQTFKNKIMSELISNGIQIYQLPTDEETAAQANSSVSGLLPFAVVGSTDEVKVGKRMVRGRHYPWGVLQVENENHCDFVKLRDMLLCTNMENLKEKTHTQHYECYRYQKLQKMGFTDVGPNNQPVSFQEIFEAKRQEFYDQCQREEEELKQRFMQRVKEKEATFKEAEKELQDKFEHLKMIQQEEIRKLEEEKKQLEGEIIDFYKMKAASEALQTQLSTDTKKDKHRKK
uniprot
proteins
function
FUNCTION: Filament-forming cytoskeletal GTPase (Probable). Involved in the migration of cortical neurons and the formation of neuron leading processes during embryonic development (By similarity). Plays a role in sperm head formation during spermiogenesis, potentially via facilitating localization of ACTN4 to cell filaments (PubMed:33228246). {ECO:0000250|UniProtKB:Q9DA97, ECO:0000269|PubMed:33228246, ECO:0000305}.
uniprot
proteins
mass_dalton
50025
uniprot
proteins
protein_family
Septin GTPase family
uniprot
proteins
protein_family
TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
17922164
uniprot
proteins
pubmed
31450874
uniprot
proteins
pubmed
32249155
uniprot
proteins
pubmed
33228246
uniprot
proteins
sequence_length
432
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17922164}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17922164, ECO:0000269|PubMed:31450874}. Cell projection, axon {ECO:0000250|UniProtKB:Q9DA97}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9DA97}. Perikaryon {ECO:0000250|UniProtKB:Q9DA97}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9DA97}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:32249155}. Note=Colocalizes with actin stress fibers (PubMed:17922164). Expressed in the perinuclear rim and manchette structure in early elongating spermatids during spermiogenesis (By similarity). {ECO:0000250|UniProtKB:Q9DA97, ECO:0000269|PubMed:17922164}.
uniprot
proteins