SEPHS2
entrez
22928
canonical
uniprot
Q99611
canonical
ensembl
ENSG00000179918
resolver
ensp
ENSP00000418669
resolver
enst
ENST00000478753
resolver
genesymbol
SEPHS2
resolver
genesymbol_syn
SPS2
resolver
hgnc
HGNC:19686
resolver
uniprot
Q9BUQ2
resolver
uniprot_entry
SPS2_HUMAN
resolver
uniprot_sec
Q9BUQ2
resolver
amino_acid_sequence
MAEASATGACGEAMAAAEGSSGPAGLTLGRSFSNYRPFEPQALGLSPSWRLTGFSGMKGUGCKVPQEALLKLLAGLTRPDVRPPLGRGLVGGQEEASQEAGLPAGAGPSPTFPALGIGMDSCVIPLRHGGLSLVQTTDFFYPLVEDPYMMGRIACANVLSDLYAMGITECDNMLMLLSVSQSMSEEEREKVTPLMVKGFRDAAEEGGTAVTGGQTVVNPWIIIGGVATVVCQPNEFIMPDSAVVGDVLVLTKPLGTQVAVNAHQWLDNPERWNKVKMVVSREEVELAYQEAMFNMATLNRTAAGLMHTFNAHAATDITGFGILGHSQNLAKQQRNEVSFVIHNLPIIAKMAAVSKASGRFGLLQGTSAETSGGLLICLPREQAARFCSEIKSSKYGEGHQAWIVGIVEKGNRTARIIDKPRVIEVLPRGATAAVLAPDSSNASSEPSS
uniprot
proteins
ec_number
2.7.9.3
uniprot
proteins
function
FUNCTION: Selenophosphate synthase that generates the selenium donor for selenocysteine biosynthesis by catalyzing formation of selenophosphate from selenide and ATP. {ECO:0000269|PubMed:15534230}.
uniprot
proteins
mass_dalton
47305
uniprot
proteins
mutagenesis
MUTAGEN 60; /note="U->C: Does not affect the selenophosphate synthase activity."; /evidence="ECO:0000269|PubMed:15534230
uniprot
proteins
post_translational_modification
PTM: Truncated SEPHS2 proteins produced by failed UGA/Sec decoding are ubiquitinated by the CRL2(KLHDC3) complex, which recognizes the glycine (Gly) at the C-terminus of truncated SEPHS2 proteins. {ECO:0000269|PubMed:26138980}.
uniprot
proteins
protein_family
Class I subfamily
uniprot
proteins
protein_family
Selenophosphate synthase 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15534230
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
16508009
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26138980
uniprot
proteins
pubmed
28414460
uniprot
proteins
pubmed
7588067
uniprot
proteins
pubmed
8986768
uniprot
proteins
sequence_length
448
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:28414460}.
uniprot
proteins