Grk1
entrez
81760
canonical
uniprot
Q63651
canonical
ensembl
ENSRNOG00000018430
resolver
ensp
ENSRNOP00000024999
resolver
genesymbol
Grk1
resolver
genesymbol_syn
Rhok
resolver
uniprot_entry
GRK1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by RCVRN, which prevents the interaction between GRK1 and RHO (By similarity). Inhibition is calcium-dependent (By similarity). {ECO:0000250|UniProtKB:P28327}.
uniprot
proteins
amino_acid_sequence
MDFGSLETVVANSAFIAARGSFDGSSTPSSRDKKYLAKLRLPPLSKCEGLRDSISLEFDNLCSEQPIGKRLFQQFLKTDERHVPALELWKDIEDYDTADDDLRPQKAQAILAEYLDPQGTLFCNFLDQGMVARVKEGPTGSQDGLFQPLLQATLEHLSQGPFQEYLGSLYFLRFLQWKWLEAQPIGEDWFLDFRVLGKGGFGEVSACQMKATGKMYACKKLNKKRLKKRKGYQGAIVEKRILAKVHSRFIVSLAYAFETKTDLCLVMTIMNGGDVRYHIYNVDEENPGFPEPRAIYYTAQIISGLEHLHQRRIVYRDLKPENVLLDNDGNIRISDLGLAVELKEGQNKTKGYAGTPGFMAPELLRGEEYDFSVDYFALGVTLYEMIAARGPFRARGEKVENKELKQRIISEPVKYPEKFSQASKDFCEQLLEKDPEKRLGFRDGTCDALRANVLFKDISWRQLEAGMLIPPFIPDSRTVYAKNIQDVGAFSTVKGVVFDKADTEFFQEFASGNCSIPWQEEMIETGFFGDLNVWRPDGQMPDDMKGITVEEAAPTAKSGMCLIS
uniprot
proteins
ec_number
2.7.11.14
uniprot
proteins
function
FUNCTION: Retina-specific kinase involved in the regulation of phototransduction, playing a key role in terminating the light-activated rhodopsin (RHO) signal in rod photoreceptors. Following light activation, it phosphorylates RHO thereby promoting binding of S-arrestin (SAG) which then blocks transducin-mediated opsin signaling (By similarity). This rapid desensitization is essential for scotopic vision and permits rapid adaptation to changes in illumination (By similarity). May play a role in the maintenance of the outer nuclear layer in the retina (By similarity). {ECO:0000250|UniProtKB:P28327, ECO:0000250|UniProtKB:Q9WVL4}.
uniprot
proteins
mass_dalton
63769
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated, Ser-21 is a minor site of autophosphorylation compared to Ser-491 and Thr-492 (By similarity). Phosphorylation at Ser-21 is regulated by light and activated by cAMP. {ECO:0000250, ECO:0000269|PubMed:21504899}.; PTM: Farnesylation is required for full activity. {ECO:0000250|UniProtKB:P28327}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
GPRK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11717351
uniprot
proteins
pubmed
21504899
uniprot
proteins
pubmed
9147475
uniprot
proteins
sequence_length
564
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P28327}; Lipid-anchor {ECO:0000250|UniProtKB:P28327}. Cell projection, cilium, photoreceptor outer segment {ECO:0000250|UniProtKB:Q9WVL4}. Note=Subcellular location is not affected by light or dark conditions. {ECO:0000250|UniProtKB:Q9WVL4}.
uniprot
proteins