Gimap5
entrez
246774
canonical
uniprot
Q8K3L6
canonical
ensembl
ENSRNOG00000008416
resolver
ensembl
ENSRNOG00055026857
resolver
ensembl
ENSRNOG00060029860
resolver
ensembl
ENSRNOG00065015562
resolver
ensp
ENSRNOP00000072663
resolver
genesymbol
Gimap5
resolver
genesymbol_syn
Ian4
resolver
genesymbol_syn
Ian4l1
resolver
genesymbol_syn
Iddm1
resolver
genesymbol_syn
Lyp
resolver
uniprot
Q0R3W7
resolver
uniprot
Q5YEJ2
resolver
uniprot
Q5YEJ3
resolver
uniprot
Q8K3L7
resolver
uniprot_entry
GIMA5_RAT
resolver
uniprot_entry
Q0R3W7_RAT
resolver
uniprot_sec
Q5YEJ2
resolver
uniprot_sec
Q5YEJ3
resolver
uniprot_sec
Q8K3L7
resolver
amino_acid_sequence
MEDHGFEELSTRTHDLNVRRLTKGNINFLLSTGQETYSVEDSGLLRILLVGKSGCGKSATGNSILRRPAFESRLRGQSVTRTSQAEMGTWEGRSFLVVDTPPIFESKIQNQDMDKDIGNCYLMCAPGPHVLLLVTQLGRYTVEDAMAVRMVKQIFGVGVMRYMIVLFTHKEDLADESLEEFVTHTGNLDLHRLVQECGRRYCAFNNKASGEEQQGQLAELMALVRRLEQEHEGSFHSNDLFVYTQVFLRGGYSEHQEPYKFYLTKVRQEVEKQKRELEEQEGSWMAKMLCRVTSCLDWHIAVSVLLIVLGLTLLITLINMYIGRWK
uniprot
proteins
disease_involvement
DISEASE: Note=Diabetes-prone biobreeding (DP-BB) rats have a frameshift mutation in Gimap5, which results in a truncated protein in which the C-terminal 215 amino acids, including the membrane anchor, are replaced by 19 other amino acids. These animals exhibit life-long T-cell lymphopenia, including lack of regulatory T cells, and spontaneously develop insulin-dependent diabetes resembling human type 1 diabetes. {ECO:0000269|PubMed:12031988}.
uniprot
proteins
function
FUNCTION: Required for mitochondrial integrity and T-cell survival. May contribute to T-cell quiescence. {ECO:0000269|PubMed:12930893, ECO:0000269|PubMed:15307172}.; FUNCTION: Plays a role in T lymphocyte development and the optimal generation of CD4/CD8 double-positive thymocytes (By similarity). Inhibitor of GSK3A, possibly by sequestering GSK3A in cytoplasmic vesicles and impairing its translocation to the nucleus. Consequently, impairs GSK3A-dependent transcriptional program and regulation of the DNA damage response occurring during T cells proliferation (By similarity). Required for the survival of peripheral T cells, natural killer (NK) and NK T-cell development and the maintenance of normal liver function (By similarity). Promotes the survival of quiescent T-cells (PubMed:15307172). May regulate Ca(2+) homeostasis by modulating lysosomal Ca(2+) stores, preventing its accumulation in the absence of T cell activation (PubMed:28223986). May play a role in mitochondrial DNA segregation in hematopoietic tissues (By similarity). Is a regulator of liver endothelial cell homeostasis (By similarity). {ECO:0000250|UniProtKB:Q8BWF2, ECO:0000250|UniProtKB:Q96F15, ECO:0000269|PubMed:15307172, ECO:0000269|PubMed:28223986}.
uniprot
proteins
mass_dalton
37266
uniprot
proteins
protein_family
AIG1/Toc34/Toc159-like paraseptin GTPase family
uniprot
proteins
protein_family
IAN subfamily
uniprot
proteins
protein_family
TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily
uniprot
proteins
pubmed
12031988
uniprot
proteins
pubmed
12930893
uniprot
proteins
pubmed
15307172
uniprot
proteins
pubmed
15474297
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21487483
uniprot
proteins
pubmed
28223986
uniprot
proteins
sequence_length
326
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:28223986}; Single-pass type IV membrane protein {ECO:0000269|PubMed:28223986}. Endosome, multivesicular body membrane {ECO:0000269|PubMed:21487483}; Single-pass type IV membrane protein {ECO:0000305}. Endosome membrane {ECO:0000269|PubMed:28223986}; Single-pass type IV membrane protein {ECO:0000269|PubMed:28223986}.
uniprot
proteins
transmembrane_region
TRANSMEM 298..318; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000305|PubMed:28223986
uniprot
proteins