RYK
entrez
6259
canonical
uniprot
P34925
canonical
ensembl
ENSG00000163785
resolver
ensp
ENSP00000478721
resolver
ensp
ENSP00000485095
resolver
genesymbol
RYK
resolver
genesymbol_syn
JTK5A
resolver
hgnc
HGNC:10481
resolver
uniprot
A0A087WUK1
resolver
uniprot
A0A096LNL3
resolver
uniprot
Q04696
resolver
uniprot
Q59FQ5
resolver
uniprot
Q8WTZ8
resolver
uniprot_entry
Q59FQ5_HUMAN
resolver
uniprot_entry
Q8WTZ8_HUMAN
resolver
uniprot_entry
RYK_HUMAN
resolver
uniprot_sec
A0A087WUK1
resolver
uniprot_sec
A0A096LNL3
resolver
uniprot_sec
Q04696
resolver
amino_acid_sequence
MRGAARLGRPGRSCLPGARGLRAPPPPPLLLLLALLPLLPAPGAAAAPAPRPPELQSASAGPSVSLYLSEDEVRRLIGLDAELYYVRNDLISHYALSFSLLVPSETNFLHFTWHAKSKVEYKLGFQVDNVLAMDMPQVNISVQGEVPRTLSVFRVELSCTGKVDSEVMILMQLNLTVNSSKNFTVLNFKRRKMCYKKLEEVKTSALDKNTSRTIYDPVHAAPTTSTRVFYISVGVCCAVIFLVAIILAVLHLHSMKRIELDDSISASSSSQGLSQPSTQTTQYLRADTPNNATPITSYPTLRIEKNDLRSVTLLEAKGKVKDIAISRERITLKDVLQEGTFGRIFHGILIDEKDPNKEKQAFVKTVKDQASEIQVTMMLTESCKLRGLHHRNLLPITHVCIEEGEKPMVILPYMNWGNLKLFLRQCKLVEANNPQAISQQDLVHMAIQIACGMSYLARREVIHKDLAARNCVIDDTLQVKITDNALSRDLFPMDYHCLGDNENRPVRWMALESLVNNEFSSASDVWAFGVTLWELMTLGQTPYVDIDPFEMAAYLKDGYRIAQPINCPDELFAVMACCWALDPEERPKFQQLVQCLTEFHAALGAYV
uniprot
proteins
function
FUNCTION: May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development. {ECO:0000269|PubMed:15454084}.
uniprot
proteins
mass_dalton
67815
uniprot
proteins
mutagenesis
MUTAGEN 337; /note="Q->G: Does not confer kinase activity. Gain of autophosphorylation activity; when associated with F-484 and G-485."; /evidence="ECO:0000269|PubMed:10454588"; MUTAGEN 364; /note="K->A: No induction of the MAPK pathway."; /evidence="ECO:0000269|PubMed:10454588"; MUTAGEN 464; /note="K->R: Does not confer kinase activity."; /evidence="ECO:0000269|PubMed:10454588"; MUTAGEN 484; /note="N->F: Gain of autophosphorylation activity. Gain of autophosphorylation activity; when associated with G-485. Gain of autophosphorylation activity; when associated with G-337 and G-485."; /evidence="ECO:0000269|PubMed:10454588"; MUTAGEN 485; /note="A->G: Gain of autophosphorylation activity. Gain of autophosphorylation activity; when associated with F-484. Gain of autophosphorylation activity; when associated with G-337 and F-484."; /evidence="ECO:0000269|PubMed:10454588
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved, in part by presenilin, in response to WNT3 stimulation. Cleavage occurs during neuronal differentiation. {ECO:0000269|PubMed:16116452}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
10454588
uniprot
proteins
pubmed
11135307
uniprot
proteins
pubmed
15454084
uniprot
proteins
pubmed
16116452
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
24107129
uniprot
proteins
pubmed
32619402
uniprot
proteins
pubmed
8386829
uniprot
proteins
pubmed
8390040
uniprot
proteins
pubmed
8726462
uniprot
proteins
sequence_length
607
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000255}. Nucleus {ECO:0000250|UniProtKB:Q01887}. Cytoplasm {ECO:0000250|UniProtKB:Q01887}. Note=In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus. {ECO:0000250|UniProtKB:Q01887}.
uniprot
proteins
transmembrane_region
TRANSMEM 228..248; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins