SLAMF7
entrez
57823
canonical
uniprot
Q9NQ25
canonical
ensembl
ENSG00000026751
resolver
ensp
ENSP00000352281
resolver
ensp
ENSP00000357021
resolver
ensp
ENSP00000357022
resolver
ensp
ENSP00000403294
resolver
ensp
ENSP00000405605
resolver
ensp
ENSP00000409965
resolver
ensp
ENSP00000416592
resolver
ensp
ENSP00000483774
resolver
ensp
ENSP00000535407
resolver
ensp
ENSP00000771535
resolver
enst
ENST00000458104
resolver
enst
ENST00000621377
resolver
genesymbol
SLAMF7
resolver
genesymbol_syn
CS1
resolver
hgnc
HGNC:21394
resolver
uniprot
A0A087X100
resolver
uniprot
A8K3U1
resolver
uniprot
B4DPU4
resolver
uniprot
B4DPY3
resolver
uniprot
B4DVL7
resolver
uniprot
B4DW98
resolver
uniprot
B4DWA3
resolver
uniprot
F6RKI3
resolver
uniprot
Q8N6Y8
resolver
uniprot
Q8ND32
resolver
uniprot
Q9NY08
resolver
uniprot
Q9NY23
resolver
uniprot_entry
A0A087X100_HUMAN
resolver
uniprot_entry
B4DVL7_HUMAN
resolver
uniprot_entry
B4DW98_HUMAN
resolver
uniprot_entry
F6RKI3_HUMAN
resolver
uniprot_entry
SLAF7_HUMAN
resolver
uniprot_sec
A8K3U1
resolver
uniprot_sec
B4DPU4
resolver
uniprot_sec
B4DPY3
resolver
uniprot_sec
B4DWA3
resolver
uniprot_sec
Q8N6Y8
resolver
uniprot_sec
Q8ND32
resolver
uniprot_sec
Q9NY08
resolver
uniprot_sec
Q9NY23
resolver
amino_acid_sequence
MAGSPTCLTLIYILWQLTGSAASGPVKELVGSVGGAVTFPLKSKVKQVDSIVWTFNTTPLVTIQPEGGTIIVTQNRNRERVDFPDGGYSLKLSKLKKNDSGIYYVGIYSSSLQQPSTQEYVLHVYEHLSKPKVTMGLQSNKNGTCVTNLTCCMEHGEEDVIYTWKALGQAANESHNGSILPISWRWGESDMTFICVARNPVSRNFSSPILARKLCEGAADDPDSSMVLLCLLLVPLLLSLFVLGLFLWFLKRERQEEYIEEKKRVDICRETPNICPHSGENTEYDTIPHTNRTILKEDPANTVYSTVEIPKKMENPHSLLTMPDTPRLFAYENVI
uniprot
proteins
function
FUNCTION: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Also acts inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of pro-inflammatory cytokines (PubMed:23695528). {ECO:0000250|UniProtKB:Q8BHK6, ECO:0000269|PubMed:11698418, ECO:0000269|PubMed:11802771, ECO:0000269|PubMed:16339536, ECO:0000269|PubMed:23695528, ECO:0000269|Ref.4}.; FUNCTION: Isoform 3 does not mediate any NK cell activation.
uniprot
proteins
mass_dalton
37421
uniprot
proteins
pubmed
11220635
uniprot
proteins
pubmed
11698418
uniprot
proteins
pubmed
11802771
uniprot
proteins
pubmed
12242590
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15368295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16339536
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
23695528
uniprot
proteins
pubmed
23956418
uniprot
proteins
sequence_length
335
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 227..247; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins