Q9Z220
uniprot
Q9Z220
canonical
amino_acid_sequence
MMRNRSKSPRRPSPTSRAANCDVDLLKSTARDREELKCMLEKYERHLAEIQGNVKVLTSVRDKTFLLYEQAQEEIARLRREMMKSCQSPKSTTAHAILRRVETERDVAFTDLRRMTTARDSLRERLKIAQAFNEKAHLEQRIEELECTVHNLDDERMEQMSNMTLMKETITIVEKEMKSLARKAMDTESELGRQKAENNSLRLLYENTEKDLSDTQRHLAKKKYELQLTQEKIMCLDEKIDNFTRQNIAQREEISILGATLNDLAKEKECLQTCLDKKSENIASLGESLAMKEKTISGMKNIIAEMEQASRQSTEALIMCEQDISRMRRQLDETNDELGQIARERDILAHENDNLQEQFAKVKQENQALSKKLNDTHNELSDIKQKVQDTNLEVNKLKNILKSEESTNLEVNKLKNILKSEESENRQIMEQLRKANEDAENWENKARQLEAENNTLKLELITAEAEGNRLKEKVDALNREVEQHLNAERSYKSQIATLHKSLVKMEEELQKVQFEKVSALADLSSTRELCIKLDSSKELLNRQLVAKDQEIEMMENELDSARSEIELLRSQMTNERISMQNLEALLVANRDKEYQSQIALQEKESEIQLLKEHLCLAENKMAIQSRDVAQFRNVVTQLEADLDITKRQLGTERFERERAVQELRRQNYSSNAYHLGSMKPNTKCHSPERAHHRSPDRDLDRSLEENLCYRDF
uniprot
proteins
function
FUNCTION: Plays a role in spermatogenesis (By similarity). When overexpressed, prevents nuclear localization of HIF1A (By similarity). {ECO:0000250|UniProtKB:Q6NY15, ECO:0000250|UniProtKB:Q9BZW7}.
uniprot
proteins
mass_dalton
83012
uniprot
proteins
post_translational_modification
PTM: Processed into N-terminal 27-kDa and C-terminal 55-kDa fragments. {ECO:0000269|PubMed:14585816}.
uniprot
proteins
protein_family
CEP135/TSGA10 family
uniprot
proteins
pubmed
14585816
uniprot
proteins
pubmed
16643851
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
712
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14585816, ECO:0000269|PubMed:16643851}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q9BZW7}. Note=In mature spermatozoa, localizes to the centriole and midpiece (By similarity). The 27-kDa N-terminal fragment associates with the fibrous sheath in mature spermatozoa and localizes to the principal piece of sperm tail, while the 55-kDa fragment localizes to the midpiece (PubMed:14585816). Detected in the cytoplasm of almost all spermatogonial cells within the seminiferous tubules (PubMed:16643851). {ECO:0000250|UniProtKB:Q9BZW7, ECO:0000269|PubMed:14585816, ECO:0000269|PubMed:16643851}.
uniprot
proteins