Adss1
entrez
11565
canonical
uniprot
P28650
canonical
ensembl
ENSMUSG00000011148
resolver
ensp
ENSMUSP00000021726
resolver
genesymbol
Adss1
resolver
genesymbol_syn
ADSS1
resolver
genesymbol_syn
ADSSL1
resolver
genesymbol_syn
Adssl1
resolver
uniprot
Q3UBP0
resolver
uniprot
Q8CHQ1
resolver
uniprot_entry
PURA1_MOUSE
resolver
uniprot_entry
Q3UBP0_MOUSE
resolver
uniprot_sec
Q8CHQ1
resolver
activity_regulation
ACTIVITY REGULATION: Weakly inhibited by AMP non-competitively to all substrates. Inhibited by IMP non-competitively with respect to GTP. Inhibited by fructose 1,6-bisphosphate competitively with respect to IMP.
uniprot
proteins
amino_acid_sequence
MSGTRASNDRPPGTGGVKRGRLQQEAAATGSRVTVVLGAQWGDEGKGKVVDLLATDADIVSRCQGGNNAGHTVVVDGKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLKDWEKRLIISDRAHLVFDFHQAVDGLQEVQRQAQEGKNIGTTKKGIGPTYSSKAARTGLRICDLLSDFDEFSARFKNLAHQHQSMFPTLEIDVEGQLKRLKGFAERIRPMVRDGVYFMYEALHGPPKKVLVEGANAALLDIDFGTYPFVTSSNCTVGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGDLLQNRGHEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLSEIKVGISYKLNGKRIPYFPANQEILQKVEVEYETLPGWKADTTGARKWEDLPPQAQSYVRFVENHMGVAVKWVGVGKSRESMIQLF
uniprot
proteins
ec_number
6.3.4.4
uniprot
proteins
function
FUNCTION: Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. {ECO:0000269|PubMed:12482871}.
uniprot
proteins
mass_dalton
50254
uniprot
proteins
pathway_participation
PATHWAY: Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2. {ECO:0000255|HAMAP-Rule:MF_03126}.
uniprot
proteins
protein_family
Adenylosuccinate synthetase family
uniprot
proteins
pubmed
11560929
uniprot
proteins
pubmed
12004071
uniprot
proteins
pubmed
12186864
uniprot
proteins
pubmed
12482871
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16981730
uniprot
proteins
pubmed
1939273
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8308018
uniprot
proteins
sequence_length
457
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Note=Partially associated with particulate fractions.
uniprot
proteins