Cyfip2
entrez
76884
canonical
uniprot
Q5SQX6
canonical
ensembl
ENSMUSG00000020340
resolver
ensp
ENSMUSP00000090853
resolver
ensp
ENSMUSP00000090854
resolver
ensp
ENSMUSP00000127586
resolver
ensp
ENSMUSP00000185923
resolver
ensp
ENSMUSP00000185945
resolver
ensp
ENSMUSP00000185946
resolver
enst
ENSMUST00000093165
resolver
enst
ENSMUST00000093166
resolver
enst
ENSMUST00000165599
resolver
genesymbol
Cyfip2
resolver
genesymbol_syn
Kiaa1168
resolver
genesymbol_syn
Pir121
resolver
uniprot
Q3UH21
resolver
uniprot
Q3UHS8
resolver
uniprot
Q6PGK0
resolver
uniprot
Q8BSW0
resolver
uniprot
Q8CHA9
resolver
uniprot
Q924D3
resolver
uniprot
Q9R181
resolver
uniprot_entry
CYFP2_MOUSE
resolver
uniprot_entry
Q6PGK0_MOUSE
resolver
uniprot_sec
Q3UH21
resolver
uniprot_sec
Q3UHS8
resolver
uniprot_sec
Q8BSW0
resolver
uniprot_sec
Q8CHA9
resolver
uniprot_sec
Q924D3
resolver
uniprot_sec
Q9R181
resolver
amino_acid_sequence
MTTHVTLEDALSNVDLLEELPLPDQQPCIEPPPSSIMYQANFDTNFEDRNAFVTGIARYIEQATVHSSMNEMLEEGHDYAVMLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTLGKFINMFAVLDELKNMKCSVKNDHSAYKRAAQFLRKMADPQSIQESQNLSMFLANHNRITQCLHQQLEVIPGYEELLADIVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLMDGNVSNIYKLDAKKRINLSKIDKFFKQLQVVPLFGDMQIELARYIKTSAHYEENKSKWTCTQSSISPQYNICEQMVQIRDDHIRFISELARYSNSEVVTGSGLDSQKSDEEYRELFDLALRGLQLLSKWSAHVMEVYSWKLVHPTDKFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVFNQAIRNTIYAALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPKGGFDIKVPRRAVGPSSTQLYMVRTMLESLIADKSGSKKTLRSSLDGPIVLAIEDFHKQSFFFTHLLNISEALQQCCDLSQLWFREFFLELTMGRRIQFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFKKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGVIIPYPPSNRYETLLKQRHVQLLGRSIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHMTLDSFDAMFREANHNVSAPYGRITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQRDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTICRLLGYQGIAVVMEELLKIVKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQSLREVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYIKEGERLEVRMKRLEAKYAPLHLVPLIERLGTPQQIAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTNGVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDLFDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAILNKYMKSVETDSSTVEHVRCFQPPIHQSLATTC
uniprot
proteins
function
FUNCTION: Part of the WAVE1 complex that regulates actin filament reorganization via its interaction with the Arp2/3 complex (By similarity). Involved in T-cell adhesion and p53-dependent induction of apoptosis (By similarity). Does not bind RNA. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (PubMed:27605705). {ECO:0000250|UniProtKB:Q96F07, ECO:0000269|PubMed:11438699, ECO:0000269|PubMed:27605705}.
uniprot
proteins
mass_dalton
145659
uniprot
proteins
protein_family
CYFIP family
uniprot
proteins
pubmed
10449408
uniprot
proteins
pubmed
11438699
uniprot
proteins
pubmed
12465718
uniprot
proteins
pubmed
15731336
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24153177
uniprot
proteins
pubmed
27605705
uniprot
proteins
sequence_length
1253
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11438699}. Nucleus {ECO:0000250|UniProtKB:Q96F07}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:11438699}. Synapse, synaptosome {ECO:0000269|PubMed:11438699}. Note=Highly expressed in the perinuclear region and enriched in synaptosomes (PubMed:11438699). {ECO:0000269|PubMed:11438699}.
uniprot
proteins