GBP6
entrez
163351
canonical
uniprot
Q6ZN66
canonical
ensembl
ENSG00000183347
resolver
ensp
ENSP00000359485
resolver
ensp
ENSP00000539929
resolver
genesymbol
GBP6
resolver
hgnc
HGNC:25395
resolver
uniprot
A2RRM3
resolver
uniprot
B4DRX0
resolver
uniprot
B4E1U2
resolver
uniprot
Q6ZN86
resolver
uniprot
Q7Z3F0
resolver
uniprot_entry
B4DRX0_HUMAN
resolver
uniprot_entry
B4E1U2_HUMAN
resolver
uniprot_entry
GBP6_HUMAN
resolver
uniprot_sec
A2RRM3
resolver
uniprot_sec
Q6ZN86
resolver
uniprot_sec
Q7Z3F0
resolver
amino_acid_sequence
MESGPKMLAPVCLVENNNEQLLVNQQAIQILEKISQPVVVVAIVGLYRTGKSYLMNHLAGQNHGFPLGSTVQSETKGIWMWCVPHPSKPNHTLVLLDTEGLGDVEKGDPKNDSWIFALAVLLCSTFVYNSMSTINHQALEQLHYVTELTELIKAKSSPRPDGVEDSTEFVSFFPDFLWTVRDFTLELKLNGHPITEDEYLENALKLIQGNNPRVQTSNFPRECIRRFFPKRKCFVFDRPTNDKDLLANIEKVSEKQLDPKFQEQTNIFCSYIFTHARTKTLREGITVTGNRLGTLAVTYVEAINSGAVPCLENAVITLAQRENSAAVQRAADYYSQQMAQRVKLPTDTLQELLDMHAACEREAIAIFMEHSFKDENQEFQKKFMETTMNKKGDFLLQNEESSVQYCQAKLNELSKGLMESISAGSFSVPGGHKLYMETKERIEQDYWQVPRKGVKAKEVFQRFLESQMVIEESILQSDKALTDREKAVAVDRAKKEAAEKEQELLKQKLQEQQQQMEAQDKSRKENIAQLKEKLQMEREHLLREQIMMLEHTQKVQNDWLHEGFKKKYEEMNAEISQFKRMIDTTKNDDTPWIARTLDNLADELTAILSAPAKLIGHGVKGVSSLFKKHKLPF
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens, such as bacterial pathogens Listeria monocytogenes and Mycobacterium bovis BCG as well as the protozoan pathogen Toxoplasma gondii (By similarity). Confers protection to several pathogens, including the bacterial pathogens Listeria monocytogenes and Mycobacterium bovis BCG as well as the protozoan pathogen Toxoplasma gondii (By similarity). {ECO:0000250|UniProtKB:A0A0G2JDV3}.
uniprot
proteins
mass_dalton
72427
uniprot
proteins
post_translational_modification
PTM: (Microbial infection) Ubiquitinated by S.flexneri IpaH9.8, leading to its degradation by the proteasome, thereby preventing its ability to promote host defense against bacterial infection. {ECO:0000269|PubMed:29144452}.
uniprot
proteins
protein_family
GB1 subfamily
uniprot
proteins
protein_family
GB1/RHD3 GTPase family
uniprot
proteins
protein_family
TRAFAC class dynamin-like GTPase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
29144452
uniprot
proteins
sequence_length
633
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000250|UniProtKB:A0A0G2JDV3}.
uniprot
proteins