Gphn
entrez
268566
canonical
uniprot
Q8BUV3
canonical
ensembl
ENSMUSG00000047454
resolver
ensp
ENSMUSP00000054064
resolver
ensp
ENSMUSP00000106018
resolver
ensp
ENSMUSP00000259563
resolver
ensp
ENSMUSP00000259564
resolver
ensp
ENSMUSP00000259565
resolver
ensp
ENSMUSP00000259567
resolver
ensp
ENSMUSP00000259568
resolver
ensp
ENSMUSP00000259569
resolver
ensp
ENSMUSP00000259572
resolver
ensp
ENSMUSP00000259574
resolver
ensp
ENSMUSP00000259585
resolver
ensp
ENSMUSP00000259589
resolver
ensp
ENSMUSP00000259597
resolver
ensp
ENSMUSP00000259603
resolver
ensp
ENSMUSP00000259606
resolver
ensp
ENSMUSP00000259612
resolver
ensp
ENSMUSP00000259618
resolver
ensp
ENSMUSP00000259622
resolver
ensp
ENSMUSP00000259634
resolver
ensp
ENSMUSP00000259640
resolver
enst
ENSMUST00000052472
resolver
enst
ENSMUST00000110388
resolver
genesymbol
Gphn
resolver
uniprot
A0JNY3
resolver
uniprot
E9QKJ1
resolver
uniprot
F6W7H1
resolver
uniprot_entry
A0JNY3_MOUSE
resolver
uniprot_entry
F6W7H1_MOUSE
resolver
uniprot_entry
GEPH_MOUSE
resolver
uniprot_sec
E9QKJ1
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by copper and tungsten. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKETLIDWCDEKELNLILTTGGTGFAPRDVTPEATKEVIEREAPGMALAMLMGSLNVTPLGMLSRPVCGIRGKTLIINLPGSKKGSQECFQFILPALPHAIDLLRDAIVKVKEVHDELEDLPSPPPPLSPPPTTSPHKQTEDKGVQCEEEEEEKKDSGVASTEDSSSSHITAAALAAKIPDSIISRGVQVLPRDTASLSTTPSESPRAQATSRLSTASCPTPKQIRRPDESKGVASRVGSLKARLPSCSSTYSVSEVQSRCSSKENILRASHSAVDITKVARRHRMSPFPLTSMDKAFITVLEMTPVLGTEIINYRDGMGRVLAQDVYAKDNLPPFPASVKDGYAVRAADGPGDRFIIGESQAGEQPTQTVMPGQVMRVTTGAPIPCGADAVVQVEDTELIRESDDGTEELEVRILVQARPGQDIRPIGHDIKRGECVLAKGTHMGPSEIGLLATVGVTEVEVNKFPVVAVMSTGNELLNPEDDLLPGKIRDSNRSTLLATIQEHGYPTINLGIVGDNPDDLLNALNEGISRADVIITSGGVSMGEKDYLKQVLDIDLHAQIHFGRVFMKPGLPTTFATLDIDGVRKIIFALPGNPVSAVVTCNLFVVPALRKMQGILDPRPTIIKARLSCDVKLDPRPEYHRCILTWHHQEPLPWAQSTGNQMSSRLMSMRSANGLLMLPPKTEQYVELHKGEVVDVMVIGRL
uniprot
proteins
ec_number
2.10.1.1
uniprot
proteins
ec_number
2.7.7.75
uniprot
proteins
function
FUNCTION: Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors (PubMed:25025157). {ECO:0000250|UniProtKB:Q03555, ECO:0000269|PubMed:25025157}.; FUNCTION: Also has a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. {ECO:0000250|UniProtKB:Q03555}.
uniprot
proteins
mass_dalton
83282
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; molybdopterin biosynthesis. {ECO:0000250|UniProtKB:Q9NQX3}.
uniprot
proteins
post_translational_modification
PTM: Palmitoylated (PubMed:25025157). Palmitoylation is stimulated by GABA type A receptors activity (PubMed:25025157). Palmitoylation by ZDHHC12 regulates clustering at synapses (PubMed:25025157). {ECO:0000269|PubMed:25025157}.
uniprot
proteins
protein_family
MoaB/Mog family; MoeA family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22126966
uniprot
proteins
pubmed
25025157
uniprot
proteins
pubmed
27373832
uniprot
proteins
pubmed
27609886
uniprot
proteins
sequence_length
769
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:Q03555}; Lipid-anchor {ECO:0000250|UniProtKB:Q03555}; Cytoplasmic side {ECO:0000250|UniProtKB:Q03555}. Cell membrane {ECO:0000250|UniProtKB:Q03555}; Lipid-anchor {ECO:0000250|UniProtKB:Q03555}; Cytoplasmic side {ECO:0000250|UniProtKB:Q03555}. Cytoplasm, cytosol {ECO:0000269|PubMed:25025157}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q03555}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9NQX3}. Postsynaptic density {ECO:0000269|PubMed:27609886}. Note=Cytoplasmic face of glycinergic postsynaptic membranes (By similarity). Forms clusters at synapses (PubMed:25025157). {ECO:0000250|UniProtKB:Q03555, ECO:0000269|PubMed:25025157}.
uniprot
proteins