Clic5
entrez
94272
canonical
uniprot
Q9EPT8
canonical
ensembl
ENSRNOG00000074354
resolver
ensembl
ENSRNOG00055007775
resolver
ensembl
ENSRNOG00060020769
resolver
ensembl
ENSRNOG00065023491
resolver
ensp
ENSRNOP00000105837
resolver
ensp
ENSRNOP00055010401
resolver
ensp
ENSRNOP00060029589
resolver
ensp
ENSRNOP00065032662
resolver
enst
ENSRNOT00000154945
resolver
enst
ENSRNOT00055013019
resolver
enst
ENSRNOT00060035958
resolver
enst
ENSRNOT00065040158
resolver
genesymbol
Clic5
resolver
uniprot_entry
CLIC5_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by F-actin. {ECO:0000250|UniProtKB:Q9NZA1}.
uniprot
proteins
amino_acid_sequence
MTDSATANGDDRDPEIELFVKAGIDGESIGNCPFSQRLFMILWLKGVVFNVTTVDLKRKPADLHNLAPGTHPPFLTFNGDVKTDVNKIEEFLEETLTPEKYPKLAARHRESNTAGIDIFSKFSAYIKNTKQQNNAALERGLTKALRKLDDYLNTPLPEEIDTNTHGDEKGSQRKFLDGDELTLADCNLLPKLHVVKIVAKKYRNYDIPAEMTGLWRYLKNAYARDEFTNTCAADSEIELAYADVARRLSRS
uniprot
proteins
ec_number
1.8.-.-
uniprot
proteins
function
FUNCTION: In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (By similarity). Can insert into membranes and form non-selective ion channels almost equally permeable to Na(+), K(+) and Cl(-) (By similarity). Required for normal hearing (By similarity). It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti (By similarity). May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture (By similarity). Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens (By similarity). {ECO:0000250|UniProtKB:O00299, ECO:0000250|UniProtKB:Q8BXK9, ECO:0000250|UniProtKB:Q9NZA1}.
uniprot
proteins
mass_dalton
28299
uniprot
proteins
protein_family
Chloride channel CLIC family
uniprot
proteins
pubmed
17021174
uniprot
proteins
pubmed
24285636
uniprot
proteins
pubmed
26777142
uniprot
proteins
sequence_length
251
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000250|UniProtKB:Q9NZA1}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9NZA1}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9NZA1}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q9NZA1}. Membrane {ECO:0000250|UniProtKB:Q9NZA1}; Single-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:17021174, ECO:0000269|PubMed:24285636}; Single-pass membrane protein {ECO:0000255}. Cytoplasm {ECO:0000250|UniProtKB:O00299}. Mitochondrion {ECO:0000269|PubMed:26777142}. Cell projection, stereocilium {ECO:0000269|PubMed:24285636}. Note=Colocalizes with AKAP9 at the Golgi apparatus as well as, to a lesser extent, the centrosome (By similarity). Associates with the cortical actin cytoskeleton (By similarity). Localizes to the apical region of cochlear hair cells, at the base of the actin-rich hair bundle (PubMed:17021174). Colocalizes with podocalyxin at the apical cell membrane in renal glomeruli (By similarity). May localize to the centrosome in lens epithelial cells (By similarity). Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain (By similarity). {ECO:0000250|UniProtKB:O00299, ECO:0000250|UniProtKB:Q8BXK9, ECO:0000250|UniProtKB:Q9NZA1, ECO:0000269|PubMed:17021174, ECO:0000269|PubMed:26777142}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..54; /note="Helical; Note=After insertion into the membrane"; /evidence="ECO:0000255
uniprot
proteins