P50391
uniprot
P50391
canonical
amino_acid_sequence
MNTSHLLALLLPKSPQGENRSKPLGTPYNFSEHCQDSVDVMVFIVTSYSIETVVGVLGNLCLMCVTVRQKEKANVTNLLIANLAFSDFLMCLLCQPLTAVYTIMDYWIFGETLCKMSAFIQCMSVTVSILSLVLVALERHQLIINPTGWKPSISQAYLGIVLIWVIACVLSLPFLANSILENVFHKNHSKALEFLADKVVCTESWPLAHHRTIYTTFLLLFQYCLPLGFILVCYARIYRCLQRQGRVFHKGTYSLRAGHMKQVNVVLVVMVVAFAVLWLPLHVFNSLEDWHHEAIPICHGNLIFLVCHLLAMASTCVNPFIYGFLNTNFKKEIKALVLTCQQSAPLEESEHLPLSTVHTEVSKGSLRLSGRSNPI
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for PPY/pancreatic polypeptide/PP, NPY/neuropeptide Y and PYY/peptide YY that is negatively coupled to cAMP (PubMed:7493937, PubMed:7592911). The rank order of affinity for these polypeptides and their derivatives is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid. {ECO:0000269|PubMed:7493937, ECO:0000269|PubMed:7592911}.
uniprot
proteins
mass_dalton
42142
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7493937
uniprot
proteins
pubmed
7592911
uniprot
proteins
pubmed
8643460
uniprot
proteins
sequence_length
375
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7493937, ECO:0000269|PubMed:7592911}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 40..60; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 88..108; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 117..137; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 156..176; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 213..233; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 264..284; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 302..322; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins