Prdx1
entrez
117254
canonical
uniprot
Q63716
canonical
ensembl
ENSRNOG00000017194
resolver
ensembl
ENSRNOG00055013251
resolver
ensembl
ENSRNOG00060029088
resolver
ensembl
ENSRNOG00065016670
resolver
ensp
ENSRNOP00000023132
resolver
ensp
ENSRNOP00055018456
resolver
ensp
ENSRNOP00060042039
resolver
ensp
ENSRNOP00065021904
resolver
enst
ENSRNOT00000023132
resolver
enst
ENSRNOT00055022725
resolver
enst
ENSRNOT00060050497
resolver
enst
ENSRNOT00065027783
resolver
genesymbol
Prdx1
resolver
genesymbol_syn
Tdpx2
resolver
uniprot_entry
PRDX1_RAT
resolver
amino_acid_sequence
MSSGNAKIGHPAPSFKATAVMPDGQFKDISLSDYKGKYVVFFFYPLDFTFVCPTEIIAFSDRAEEFKKLNCQVIGASVDSHFCHLAWINTPKKQGGLGPMNIPLVSDPKRTIAQDYGVLKADEGISFRGLFIIDDKGILRQITINDLPVGRSVDEILRLVQAFQFTDKHGEVCPAGWKPGSDTIKPDVNKSKEYFSKQK
uniprot
proteins
ec_number
1.11.1.24
uniprot
proteins
function
FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation (By similarity). {ECO:0000250|UniProtKB:P0CB50, ECO:0000250|UniProtKB:Q06830}.
uniprot
proteins
mass_dalton
22109
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Thr-90 during the M-phase, which leads to a decrease in enzymatic activity. {ECO:0000250|UniProtKB:Q06830}.; PTM: Acetylation increases reducing activity and resistance to superoxidation. Deacetylated by HDAC6 which decreases reducing activity. {ECO:0000250|UniProtKB:Q06830}.
uniprot
proteins
protein_family
AhpC/Prx1 subfamily
uniprot
proteins
protein_family
Peroxiredoxin family
uniprot
proteins
pubmed
10535922
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974571
uniprot
proteins
pubmed
7577926
uniprot
proteins
sequence_length
199
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q06830}.
uniprot
proteins