RGS10
entrez
6001
canonical
uniprot
O43665
canonical
ensembl
ENSG00000148908
resolver
ensp
ENSP00000358099
resolver
ensp
ENSP00000376605
resolver
genesymbol
RGS10
resolver
hgnc
HGNC:9992
resolver
uniprot
A8K408
resolver
uniprot
B1AMR8
resolver
uniprot
Q6IAZ6
resolver
uniprot
Q96GN0
resolver
uniprot_entry
RGS10_HUMAN
resolver
uniprot_sec
A8K408
resolver
uniprot_sec
B1AMR8
resolver
uniprot_sec
Q6IAZ6
resolver
uniprot_sec
Q96GN0
resolver
amino_acid_sequence
MFNRAVSRLSRKRPPSDIHDSDGSSSSSHQSLKSTAKWAASLENLLEDPEGVKRFREFLKKEFSEENVLFWLACEDFKKMQDKTQMQEKAKEIYMTFLSSKASSQVNVEGQSRLNEKILEEPHPLMFQKLQDQIFNLMKYDSYSRFLKSDLFLKHKRTEEEEEDLPDAQTAAKRASRIYNT
uniprot
proteins
function
FUNCTION: Regulates G protein-coupled receptor signaling cascades, including signaling downstream of the muscarinic acetylcholine receptor CHRM2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:10608901, PubMed:11443111, PubMed:18434541, PubMed:8774883, PubMed:9353196). Modulates the activity of potassium channels that are activated in response to CHRM2 signaling (PubMed:11443111). Activity on GNAZ is inhibited by palmitoylation of the G protein (PubMed:9353196). {ECO:0000269|PubMed:10608901, ECO:0000269|PubMed:11443111, ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:8774883, ECO:0000269|PubMed:9353196}.
uniprot
proteins
mass_dalton
21210
uniprot
proteins
mutagenesis
MUTAGEN 176; /note="S->A: Abolishes phosphorylation site and leads to strongly reduced overall phosphorylation."; /evidence="ECO:0000269|PubMed:11443111
uniprot
proteins
pubmed
10608901
uniprot
proteins
pubmed
10791963
uniprot
proteins
pubmed
11443111
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18434541
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8774883
uniprot
proteins
pubmed
9353196
uniprot
proteins
sequence_length
181
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytosol {ECO:0000269|PubMed:11443111}. Nucleus {ECO:0000269|PubMed:11443111}. Note=Forskolin treatment promotes phosphorylation and translocation to the nucleus. {ECO:0000269|PubMed:11443111}.; SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10791963}.
uniprot
proteins