Q8CH34
uniprot
Q8CH34
canonical
amino_acid_sequence
MARQALRSTLWLLPSILLCFPFCLPLSGQHVTELPGVLHCGLQSFQFAVNLSLEAESPVLTTWDSQGLPHRLKNDSDCGTWVMDSPDGFLVLEASYSGCYVTLEGSHYIMTVGVQEADVAGHVAGTRQRLLTCPLALQGKAPDTPNAKVCSPVPVKERLPCASSTISRGDCEELGCCYSSEEEGADSCYYGNTVTSHCTKEGHFSIAVSRDVTSPPLRLDSLRLGFRNITTGCDPVMKTSTFVLFQFPLTSCGTTQRITGDQAMYENELVAIRDVQAWGRSSITRDSNFRLRVSCTYSIHSIMSPVNMQVWTLPPPLPKTQPGPLSLELQIAQDKNYSSYYGTDAYPLVKFLQDPIYVEVSILHRTDPSLSLLLEQCWATPGSNPFHQPQWPILVKGCPYAGDNYQTKRIPVQKASDVFPSHHQRFSISTFSFMSAGREKQVLGGQVYLHCSASVCQPAGMPSCTVICPASRRRRKSELYFDNSTSISSKGPVILLQATKDPAVMLHKHSGTHADSPTLWVMGLSASMVITGVLVVSYLATRKQR
uniprot
proteins
function
FUNCTION: Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP4 may act as a sperm receptor.
uniprot
proteins
mass_dalton
59874
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.
uniprot
proteins
protein_family
ZP domain family
uniprot
proteins
protein_family
ZPB subfamily
uniprot
proteins
sequence_length
545
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Processed zona pellucida sperm-binding protein 4]: Zona pellucida {ECO:0000250|UniProtKB:Q00193}.; SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q00193}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 519..539; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins