Ranbp1
entrez
19385
canonical
uniprot
P34022
canonical
ensembl
ENSMUSG00000005732
resolver
ensp
ENSMUSP00000111309
resolver
enst
ENSMUST00000115645
resolver
genesymbol
Ranbp1
resolver
genesymbol_syn
Htf9-a
resolver
genesymbol_syn
Htf9a
resolver
uniprot
P34023
resolver
uniprot
Q3TL81
resolver
uniprot
Q9D894
resolver
uniprot
Q9DCA3
resolver
uniprot_entry
RANG_MOUSE
resolver
uniprot_sec
P34023
resolver
uniprot_sec
Q3TL81
resolver
uniprot_sec
Q9D894
resolver
uniprot_sec
Q9DCA3
resolver
amino_acid_sequence
MAAAKDSHEDHDTSTENADESNHDPQFEPIVSLPEQEIKTLEEDEEELFKMRAKLFRFASENDLPEWKERGTGDVKLLKHKEKGTIRLLMRRDKTLKICANHYITPMMELKPNAGSDRAWVWNTHADFADECPKPELLAIRFLNAENAQKFKTKFEECRKEIEEREKKGPGKNDNAEKVAEKLEALSVREAREEAEEKSEEKQ
uniprot
proteins
function
FUNCTION: Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus (PubMed:9428644). Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins (By similarity). Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L (PubMed:9428644). Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN (By similarity). Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1 (PubMed:9428644). Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP (By similarity). {ECO:0000250|UniProtKB:P43487, ECO:0000269|PubMed:9428644}.
uniprot
proteins
mass_dalton
23596
uniprot
proteins
protein_family
RANBP1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
1889746
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
7891706
uniprot
proteins
pubmed
8255297
uniprot
proteins
pubmed
8896452
uniprot
proteins
pubmed
9428644
uniprot
proteins
sequence_length
203
uniprot
proteins