BAK1
entrez
578
canonical
uniprot
Q16611
canonical
ensembl
ENSG00000030110
resolver
ensp
ENSP00000363591
resolver
ensp
ENSP00000556854
resolver
genesymbol
BAK1
resolver
genesymbol_syn
BAK
resolver
genesymbol_syn
BCL2L7
resolver
genesymbol_syn
CDN1
resolver
hgnc
HGNC:949
resolver
uniprot
A0A0S2Z391
resolver
uniprot
C0H5Y7
resolver
uniprot
Q6I9T6
resolver
uniprot
Q92533
resolver
uniprot_entry
A0A0S2Z391_HUMAN
resolver
uniprot_entry
BAK_HUMAN
resolver
uniprot_sec
C0H5Y7
resolver
uniprot_sec
Q6I9T6
resolver
uniprot_sec
Q92533
resolver
amino_acid_sequence
MASGQGPGPPRQECGEPALPSASEEQVAQDTEEVFRSYVFYRHQQEQEAEGVAAPADPEMVTLPLQPSSTMGQVGRQLAIIGDDINRRYDSEFQTMLQHLQPTAENAYEYFTKIATSLFESGINWGRVVALLGFGYRLALHVYQHGLTGFLGQVTRFVVDFMLHHCIARWIAQRGGWVAALNLGNGPILNVLVVLGVVLLGQFVVRRFFKS
uniprot
proteins
function
FUNCTION: Plays a role in the mitochondrial apoptotic process. Upon arrival of cell death signals, promotes mitochondrial outer membrane (MOM) permeabilization by oligomerizing to form pores within the MOM. This releases apoptogenic factors into the cytosol, including cytochrome c, promoting the activation of caspase 9 which in turn processes and activates the effector caspases. {ECO:0000269|PubMed:17157251, ECO:0000269|PubMed:8521816}.
uniprot
proteins
mass_dalton
23409
uniprot
proteins
mutagenesis
MUTAGEN 164; /note="H->A: Strongly reduced zinc binding and homodimerization."; /evidence="ECO:0000269|PubMed:17157251
uniprot
proteins
protein_family
Bcl-2 family
uniprot
proteins
pubmed
10233985
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16439990
uniprot
proteins
pubmed
16509771
uniprot
proteins
pubmed
17157251
uniprot
proteins
pubmed
17386268
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23055042
uniprot
proteins
pubmed
25296756
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29531808
uniprot
proteins
pubmed
7715729
uniprot
proteins
pubmed
7715730
uniprot
proteins
pubmed
7715731
uniprot
proteins
pubmed
8521816
uniprot
proteins
pubmed
9020082
uniprot
proteins
sequence_length
211
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:29531808}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 188..205; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins