SLC30A6
entrez
55676
canonical
uniprot
Q6NXT4
canonical
ensembl
ENSG00000152683
resolver
ensp
ENSP00000282587
resolver
ensp
ENSP00000349563
resolver
ensp
ENSP00000368648
resolver
ensp
ENSP00000384041
resolver
ensp
ENSP00000399005
resolver
ensp
ENSP00000735106
resolver
ensp
ENSP00000786609
resolver
ensp
ENSP00000786611
resolver
ensp
ENSP00000794861
resolver
enst
ENST00000406369
resolver
genesymbol
SLC30A6
resolver
genesymbol_syn
ZNT6
resolver
hgnc
HGNC:19305
resolver
uniprot
A5YM45
resolver
uniprot
B3KU87
resolver
uniprot
B5MCR8
resolver
uniprot
B7WP49
resolver
uniprot
B7Z901
resolver
uniprot
D6W579
resolver
uniprot
Q8N5C9
resolver
uniprot
Q96NC3
resolver
uniprot_entry
B3KU87_HUMAN
resolver
uniprot_entry
B5MCR8_HUMAN
resolver
uniprot_entry
ZNT6_HUMAN
resolver
uniprot_sec
A5YM45
resolver
uniprot_sec
B7WP49
resolver
uniprot_sec
B7Z901
resolver
uniprot_sec
D6W579
resolver
uniprot_sec
Q8N5C9
resolver
uniprot_sec
Q96NC3
resolver
amino_acid_sequence
MGTIHLFRKPQRSFFGKLLREFRLVAADRRSWKILLFGVINLICTGFLLMWCSSTNSIALTAYTYLTIFDLFSLMTCLISYWVTLRKPSPVYSFGFERLEVLAVFASTVLAQLGALFILKESAERFLEQPEIHTGRLLVGTFVALCFNLFTMLSIRNKPFAYVSEAASTSWLQEHVADLSRSLCGIIPGLSSIFLPRMNPFVLIDLAGAFALCITYMLIEINNYFAVDTASAIAIALMTFGTMYPMSVYSGKVLLQTTPPHVIGQLDKLIREVSTLDGVLEVRNEHFWTLGFGSLAGSVHVRIRRDANEQMVLAHVTNRLYTLVSTLTVQIFKDDWIRPALLSGPVAANVLNFSDHHVIPMPLLKGTDDLNPVTSTPAKPSSPPPEFSFNTPGKNVNPVILLNTQTRPYGFGLNHGHTPYSSMLNQGLGVPGIGATQGLRTGFTNIPSRYGTNNRIGQPRP
uniprot
proteins
function
FUNCTION: Has probably no intrinsic transporter activity but together with SLC30A5 forms a functional zinc ion:proton antiporter heterodimer, mediating zinc entry into the lumen of organelles along the secretory pathway (PubMed:15994300, PubMed:19366695, PubMed:19759014). As part of that zinc ion:proton antiporter, contributes to zinc ion homeostasis within the early secretory pathway and regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis (PubMed:15994300, PubMed:19759014, PubMed:35525268). {ECO:0000269|PubMed:15994300, ECO:0000269|PubMed:19366695, ECO:0000269|PubMed:19759014, ECO:0000269|PubMed:35525268}.
uniprot
proteins
mass_dalton
51116
uniprot
proteins
mutagenesis
MUTAGEN 66; /note="L->H: No effect on heterodimer formation with SLC30A5 and no effect on zinc transport; when associated with H-201."; /evidence="ECO:0000269|PubMed:19759014"; MUTAGEN 70; /note="D->A: No effect on heterodimer formation with SLC30A5 and no effect on zinc transport; when associated with A-205."; /evidence="ECO:0000269|PubMed:19759014"; MUTAGEN 201; /note="F->H: No effect on heterodimer formation with SLC30A5 and no effect on zinc transport; when associated with H-66."; /evidence="ECO:0000269|PubMed:19759014"; MUTAGEN 205; /note="D->A: No effect on heterodimer formation with SLC30A5 and no effect on zinc transport; when associated with A-70."; /evidence="ECO:0000269|PubMed:19759014
uniprot
proteins
protein_family
Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
uniprot
proteins
protein_family
SLC30A subfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15154973
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
15994300
uniprot
proteins
pubmed
16580781
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19366695
uniprot
proteins
pubmed
19759014
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
35525268
uniprot
proteins
sequence_length
461
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:19366695}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000250|UniProtKB:Q8BJM5}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..54; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 65..85; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 99..119; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 135..155; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 201..221; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 224..244; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins