PLIN1
entrez
5346
canonical
uniprot
O60240
canonical
ensembl
ENSG00000166819
resolver
ensp
ENSP00000300055
resolver
ensp
ENSP00000402167
resolver
ensp
ENSP00000566728
resolver
ensp
ENSP00000627152
resolver
ensp
ENSP00000627153
resolver
enst
ENST00000300055
resolver
enst
ENST00000430628
resolver
enst
ENST00000896669
resolver
enst
ENST00000957093
resolver
enst
ENST00000957094
resolver
genesymbol
PLIN1
resolver
genesymbol_syn
PERI
resolver
genesymbol_syn
PLIN
resolver
hgnc
HGNC:9076
resolver
uniprot
Q8N5Y6
resolver
uniprot_entry
PLIN1_HUMAN
resolver
uniprot_sec
Q8N5Y6
resolver
amino_acid_sequence
MAVNKGLTLLDGDLPEQENVLQRVLQLPVVSGTCECFQKTYTSTKEAHPLVASVCNAYEKGVQSASSLAAWSMEPVVRRLSTQFTAANELACRGLDHLEEKIPALQYPPEKIASELKDTISTRLRSARNSISVPIASTSDKVLGAALAGCELAWGVARDTAEFAANTRAGRLASGGADLALGSIEKVVEYLLPPDKEESAPAPGHQQAQKSPKAKPSLLSRVGALTNTLSRYTVQTMARALEQGHTVAMWIPGVVPLSSLAQWGASVAMQAVSRRRSEVRVPWLHSLAAAQEEDHEDQTDTEGEDTEEEEELETEENKFSEVAALPGPRGLLGGVAHTLQKTLQTTISAVTWAPAAVLGMAGRVLHLTPAPAVSSTKGRAMSLSDALKGVTDNVVDTVVHYVPLPRLSLMEPESEFRDIDNPPAEVERREAERRASGAPSAGPEPAPRLAQPRRSLRSAQSPGAPPGPGLEDEVATPAAPRPGFPAVPREKPKRRVSDSFFRPSVMEPILGRTHYSQLRKKS
uniprot
proteins
disease_involvement
DISEASE: Lipodystrophy, familial partial, 4 (FPLD4) [MIM:613877]: An autosomal dominant form of lipodystrophy characterized by loss of subcutaneous adipose tissue primarily affecting the lower limbs, insulin-resistant diabetes mellitus, hypertriglyceridemia, and hypertension. {ECO:0000269|PubMed:21345103}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Modulator of adipocyte lipid metabolism. Coats lipid storage droplets to protect them from breakdown by hormone-sensitive lipase (HSL). Its absence may result in leanness. Plays a role in unilocular lipid droplet formation by activating CIDEC. Their interaction promotes lipid droplet enlargement and directional net neutral lipid transfer. May modulate lipolysis and triglyceride levels. {ECO:0000269|PubMed:23399566}.
uniprot
proteins
mass_dalton
55990
uniprot
proteins
post_translational_modification
PTM: Major cAMP-dependent protein kinase-substrate in adipocytes, also dephosphorylated by PP1. When phosphorylated, may be maximally sensitive to HSL and when unphosphorylated, may play a role in the inhibition of lipolysis, by acting as a barrier in lipid droplet (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Perilipin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
21345103
uniprot
proteins
pubmed
23399566
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26357594
uniprot
proteins
pubmed
27832861
uniprot
proteins
pubmed
9521880
uniprot
proteins
sequence_length
522
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:23399566}. Lipid droplet {ECO:0000269|PubMed:23399566, ECO:0000305|PubMed:26357594}. Note=Lipid droplet surface-associated. {ECO:0000269|PubMed:23399566}.
uniprot
proteins