FBXO25
entrez
26260
canonical
uniprot
Q8TCJ0
canonical
ensembl
ENSG00000147364
resolver
ensp
ENSP00000341345
resolver
ensp
ENSP00000342077
resolver
ensp
ENSP00000372274
resolver
ensp
ENSP00000578044
resolver
ensp
ENSP00000578046
resolver
ensp
ENSP00000582254
resolver
ensp
ENSP00000626472
resolver
ensp
ENSP00000626475
resolver
ensp
ENSP00000626477
resolver
genesymbol
FBXO25
resolver
genesymbol_syn
FBX25
resolver
hgnc
HGNC:13596
resolver
uniprot
Q6PJ83
resolver
uniprot
Q7Z4V4
resolver
uniprot
Q9UKB8
resolver
uniprot_entry
FBX25_HUMAN
resolver
uniprot_sec
Q6PJ83
resolver
uniprot_sec
Q7Z4V4
resolver
uniprot_sec
Q9UKB8
resolver
amino_acid_sequence
MPFLGQDWRSPGWSWIKTEDGWKRCESCSQKLERENNRCNISHSIILNSEDGEIFNNEEHEYASKKRKKDHFRNDTNTQSFYREKWIYVHKESTKERHGYCTLGEAFNRLDFSSAIQDIRRFNYVVKLLQLIAKSQLTSLSGVAQKNYFNILDKIVQKVLDDHHNPRLIKDLLQDLSSTLCILIRGVGKSVLVGNINIWICRLETILAWQQQLQDLQMTKQVNNGLTLSDLPLHMLNNILYRFSDGWDIITLGQVTPTLYMLSEDRQLWKKLCQYHFAEKQFCRHLILSEKGHIEWKLMYFALQKHYPAKEQYGDTLHFCRHCSILFWKDYHLALLFKDSGHPCTAADPDSCFTPVSPQHFIDLFKF
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving FBXO25 is a cause of X-linked intellectual disability (XLID). Translocation t(X;8)(p11.22;p23.3) with SHROOM4.
uniprot
proteins
function
FUNCTION: Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT) (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
43313
uniprot
proteins
mutagenesis
MUTAGEN 244; /note="S->L: Loss of SKP1-binding."; /evidence="ECO:0000269|PubMed:16278047
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
10531035
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16249884
uniprot
proteins
pubmed
16278047
uniprot
proteins
pubmed
18287534
uniprot
proteins
pubmed
20473970
uniprot
proteins
sequence_length
367
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16278047, ECO:0000269|PubMed:18287534}. Note=In the nucleus, associates with a subnuclear dot-like structure. Colocalized with SKP1.
uniprot
proteins