Dpy19l2
entrez
320752
canonical
uniprot
P0CW70
canonical
ensembl
ENSMUSG00000085576
resolver
ensp
ENSMUSP00000132092
resolver
enst
ENSMUST00000133010
resolver
genesymbol
Dpy19l2
resolver
uniprot_entry
D19L2_MOUSE
resolver
amino_acid_sequence
MVGPTRSKLREGSSDRPQSSCTGQARRRWSAATMEPQQERSAPQERTKWSLLQHFLLGGRKLPSGARNYAARRIQSLNAQNYFQLEEVAKLLLLNRFQFLFTLLDHFREKVQALQMHRFSHRTLFGLAIFVGILHWLHLITLFENDHHFSHLSSLEREMTFRTEMGLYYSYFKTIIEAPSFLEGLWMIMNDRLTEYPLVINTVKRFHLYPEVVIAYWYRTIIGIMNLFGIETKTCWNVTRMEPLNEVQSCEGLGDPACFYIGVIFILNGLMMGLFFIYSTYLSGSQLGGLITVACYFFNHGEATRVMWTPPLRESFSYPFLVLQMYILTIILRTSTVHKKHYMALCFSNVAFMLPWQFAQFILFTQIASLFPMYVVGYIEPSKFQKIIYVNMSSVALCFILMFGNSMYLSSYYSSCLLVTWAIMQKKSKIQKLGGTELQFWLIQGCFWWCGTIILKFLTSKICGVSDHIRLSDLIAARILRYTDFDTLIYTCAPEFDFMEQATPLRYIKTLLLPLILVITYLIFKKIVRDIMCVLYTNTYVRKQLLDNAELIFHTLQLLAFTGLAILIMRLKLFLTPHMCIMASLICSQRLFGWLFCRIHFENVVFGILTMMSIQGCANLHNQWSIMGEFTNLPQEELIHWIKHSTRPDAVFAGAMPTMASIKLSTLRPIVNHPHYEDADLRARTKIVYSVYSRKSAVEVRNNLLKLHVNYYVLEEAWCVVRTKPGCSMLEIWDVEDPSNAANPPLCSILLKDSRPYFTTVFQNSMYRVLKIN
uniprot
proteins
ec_number
2.4.1.-
uniprot
proteins
function
FUNCTION: Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. {ECO:0000250|UniProtKB:P34413}.; FUNCTION: Required during spermatogenesis for sperm head elongation and acrosome formation. Also plays a role in acrosome attachment to the nuclear envelope. {ECO:0000269|PubMed:22764053, ECO:0000269|PubMed:34471926}.
uniprot
proteins
mass_dalton
89882
uniprot
proteins
protein_family
Dpy-19 family
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21397064
uniprot
proteins
pubmed
22764053
uniprot
proteins
pubmed
34471926
uniprot
proteins
sequence_length
773
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000269|PubMed:22764053, ECO:0000269|PubMed:34471926}; Multi-pass membrane protein {ECO:0000305}. Note=Restricted to the inner nuclear membrane facing the acrosomal vesicle. The N- and C-termini are oriented towards the nucleoplasm (PubMed:22764053). Colocalizes with FAM209 at the inner nuclear membrane (PubMed:34471926). {ECO:0000269|PubMed:22764053, ECO:0000269|PubMed:34471926}.
uniprot
proteins
transmembrane_region
TRANSMEM 123..143; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 210..230; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 257..277; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 312..332; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 359..379; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 387..407; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 438..458; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 508..528; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 549..569; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 591..611; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins