H1-8
entrez
132243
canonical
uniprot
Q8IZA3
canonical
ensembl
ENSG00000178804
resolver
ensp
ENSP00000319799
resolver
ensp
ENSP00000422964
resolver
genesymbol
H1-8
resolver
genesymbol_syn
H1FOO
resolver
genesymbol_syn
H1OO
resolver
genesymbol_syn
OSH1
resolver
hgnc
HGNC:18463
resolver
uniprot
Q86WT7
resolver
uniprot_entry
H18_HUMAN
resolver
uniprot_sec
Q86WT7
resolver
amino_acid_sequence
MAPGSVTSDISPSSTSTAGSSRSPESEKPGPSHGGVPPGGPSHSSLPVGRRHPPVLRMVLEALQAGEQRRGTSVAAIKLYILHKYPTVDVLRFKYLLKQALATGMRRGLLARPLNSKARGATGSFKLVPKHKKKIQPRKMAPATAPRRAGEAKGKGPKKPSEAKEDPPNVGKVKKAAKRPAKVQKPPPKPGAATEKARKQGGAAKDTRAQSGEARKVPPKPDKAMRAPSSAGGLSRKAKAKGSRSSQGDAEAYRKTKAESKSSKPTASKVKNGAASPTKKKVVAKAKAPKAGQGPNTKAAAPAKGSGSKVVPAHLSRKTEAPKGPRKAGLPIKASSSKVSSQRAEA
uniprot
proteins
function
FUNCTION: May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
35813
uniprot
proteins
protein_family
Histone H1/H5 family
uniprot
proteins
pubmed
12711322
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
346
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00837}. Chromosome {ECO:0000255|PROSITE-ProRule:PRU00837}.
uniprot
proteins