Inhibition of host TAP by virus
uniprot_keyword
KW-1107
canonical
name
Inhibition of host TAP by virus
uniprot
definition
Viral protein involved in the evasion of host adaptive immune response by inhibiting the TAP complex. Transporter associated with antigen (TAP), composed of two subunits TAP1 and TAP2, is required for the translocation of peptides into the ER, where they are loaded onto MHC class I. Thereafter, the viral peptides are presented to cytotoxic T lymphocytes at the cell surface and trigger immune response. The loading of peptide on MHC by TAP is targeted by several viruses including herpesviruses and retroviruses.
uniprot
keywords
is_obsolete
false
uniprot
keywords
ontology_id
uniprot_keywords
uniprot
keywords