ILRUN
entrez
64771
canonical
uniprot
Q9H6K1
canonical
ensembl
ENSG00000196821
resolver
ensp
ENSP00000363135
resolver
ensp
ENSP00000363138
resolver
ensp
ENSP00000782359
resolver
genesymbol
ILRUN
resolver
genesymbol_syn
C6orf106
resolver
hgnc
HGNC:21215
resolver
uniprot
B2R8K7
resolver
uniprot
Q5VV77
resolver
uniprot
Q96MG5
resolver
uniprot
Q9BUR9
resolver
uniprot_entry
ILRUN_HUMAN
resolver
uniprot_sec
B2R8K7
resolver
uniprot_sec
Q5VV77
resolver
uniprot_sec
Q96MG5
resolver
uniprot_sec
Q9BUR9
resolver
amino_acid_sequence
MEGMDVDLDPELMQKFSCLGTTDKDVLISEFQRLLGFQLNPAGCAFFLDMTNWNLQAAIGAYYDFESPNISVPSMSFVEDVTIGEGESIPPDTQFVKTWRIQNSGAEAWPPGVCLKYVGGDQFGHVNMVMVRSLEPQEIADVSVQMCSPSRAGMYQGQWRMCTATGLYYGDVIWVILSVEVGGLLGVTQQLSSFETEFNTQPHRKVEGNFNPFASPQKNRQSDENNLKDPGGSEFDSISKNTWAPAPDTWAPAPDQTEQDQNRLSQNSVNLSPSSHANNLSVVTYSKGLHGPYPFGQS
uniprot
proteins
function
FUNCTION: Negative regulator of innate antiviral response. Blocks IRF3-dependent cytokine production such as IFNA, IFNB and TNF (PubMed:29802199). Interacts with IRF3 and inhibits IRF3 recruitment to type I IFN promoter sequences while also reducing nuclear levels of the coactivators EP300 and CREBBP (PubMed:29802199). {ECO:0000269|PubMed:29802199}.
uniprot
proteins
mass_dalton
32872
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25736925
uniprot
proteins
pubmed
29802199
uniprot
proteins
sequence_length
298
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:25736925, ECO:0000269|PubMed:29802199}. Nucleus {ECO:0000269|PubMed:29802199}.
uniprot
proteins