G6pdx
entrez
24377
canonical
uniprot
P05370
canonical
ensembl
ENSRNOG00000056728
resolver
ensembl
ENSRNOG00055023864
resolver
ensembl
ENSRNOG00060006994
resolver
ensembl
ENSRNOG00065015294
resolver
ensp
ENSRNOP00000075297
resolver
ensp
ENSRNOP00055033277
resolver
ensp
ENSRNOP00060008600
resolver
ensp
ENSRNOP00065019888
resolver
enst
ENSRNOT00055040946
resolver
enst
ENSRNOT00060011479
resolver
enst
ENSRNOT00065025363
resolver
genesymbol
G6pdx
resolver
genesymbol_syn
G6pd
resolver
uniprot_entry
G6PD_RAT
resolver
amino_acid_sequence
MAEQVALSRTQVCGILREELYQGDAFHQADTHIFIIMGASGDLAKKKIYPTIWWLFRDGLLPEDTFIVGYARSRLTVDDIRKQSEPFFKVTPEERPKLEEFFARNSYVAGQYDDPASYKHLNSHMNALHQGMQANRLFYLALPPTVYEAVTKNIQEICMSQTGWNRIIVEKPFGRDLQSSNQLSNHISSLFREDQIYRIDHYLGKEMVQNLMVLRFANRIFGPIWNRDNIACVILTFKEPFGTEGRGGYFDEFGIIRDVMQNHLLQMLCLVAMEKPASTDSDDVRDEKVKVLKCISEVETDNVVLGQYVGNPSGEGEATNGYLDDPTVPHGSTTATFAAAVLYVENERWDGVPFILRCGKALNERKAEVRLQFRDVAGDIFHQQCKRNELVIRVQPNEAVYTKMMTKKPGMFFNPEESELDLTYGNRYKNVKLPDAYERLILDVFCGSQMHFVRSDELREAWRIFTPLLHKIDREKPQPIPYVYGSRGPTEADELMKRVGFQYEGTYKWVNPHKL
uniprot
proteins
ec_number
1.-.-.-
uniprot
proteins
ec_number
1.1.1.49
uniprot
proteins
function
FUNCTION: Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. Also catalyzes the conversion of NAADPH, which is produced by enzymes such as DUOX1, DUOX2 and NOX5 from NAADP and promotes Ca(2+) signaling during T cell activation, back to NAADP. {ECO:0000250|UniProtKB:P11413}.
uniprot
proteins
mass_dalton
59376
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3. {ECO:0000250|UniProtKB:P11413}.
uniprot
proteins
post_translational_modification
PTM: Acetylated by ELP3 at Lys-403; acetylation inhibits its homodimerization and enzyme activity. Deacetylated by SIRT2 at Lys-403; deacetylation stimulates its enzyme activity (By similarity). {ECO:0000250|UniProtKB:P11413}.
uniprot
proteins
protein_family
Glucose-6-phosphate dehydrogenase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2606104
uniprot
proteins
pubmed
3412913
uniprot
proteins
sequence_length
515
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P11413}. Membrane {ECO:0000250|UniProtKB:P11413}; Peripheral membrane protein {ECO:0000250|UniProtKB:P11413}.
uniprot
proteins