Micall1
entrez
362958
canonical
uniprot
D3ZQL6
canonical
ensembl
ENSRNOG00000026212
resolver
ensembl
ENSRNOG00065032973
resolver
ensp
ENSRNOP00000034618
resolver
ensp
ENSRNOP00065046732
resolver
enst
ENSRNOT00000036357
resolver
enst
ENSRNOT00065056753
resolver
genesymbol
Micall1
resolver
uniprot_entry
MILK1_RAT
resolver
amino_acid_sequence
MAGPRGALLAWCRRQCEGYRGVDIRDLSSSFRDGLAFCAILHRHRPDLLDFQSLSKENVFENNRLAFEVAEKELGIPALLDPNDMVSMSVPDCLSIMTYVSQYYNHFTSSGQAAASPPKPGKDPAAPSPTSTSPAVQPGEEAQGDDLSPDSLSEQGKPQPPSSACAACGQRVHLVQRYLAEGRLYHRHCFRCRQCSSTLVPGSYSSGPEEGTFVCAERCTRLGLGGRSGTRPLSLQKQQPAAAAEAKDGEDSDLSKSVVVVAAEADGLQASSEVQPHTLTKPPLPSKPQDLASPPVSRPTPAPRKASESSALTPPTPRPRSSLQQDGMVEQSVSGDLVNGRLQELPVPKPRGTPKLSERMTAPRKDPPWITLVQTEPKKKPAPLPPSSGPGPLSQASRQVENGGLEEKTQKSPAAEPEPKPYNPFEEEEEEEEASVPAVPSPAPAPPETTPKSLHPWYNITPTSSPKTKKRPAPKAPSASPLVLHASRLSHSEPPSATPSPALSVESLSSESSSHTANTEPSEPPAVPKSSSDPAVHVPGTPGTSANSVTPSAHSSLSSSGELGQPSGEQMPQARTRGSPGTHSTKPFSGATPTPFLLAGDQKSPAPPMGSSSPQMLIKSSCKENPFNRKPSPSTSPTVRKATKGAKPVRPPAPGHGFPLIKRKVQADQYIPEEDIYGEMDSIERQLDALEHSGVLLEEKLRGGANEGSEDDMLVDWFKLIHEKHLLVRRESELIYVFKQQNLEQRQADVEFELRCLLNKPEKDWTDDDRAREKVLMQELMTLIEQRDAIVNCLDEDRQREEEEDKMLETMIKKKDFQREAESDSKKKGKFKTMKVLKLLGNKRDAKSKAPTGKS
uniprot
proteins
function
FUNCTION: Lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. On endosome membranes, acts as a downstream effector of Rab proteins recruiting cytosolic proteins to regulate membrane tubulation. Involved in a late step of receptor-mediated endocytosis regulating for instance endocytosed-EGF receptor trafficking. Alternatively, regulates slow endocytic recycling of endocytosed proteins back to the plasma membrane. Also involved in cargo protein delivery to the plasma membrane. Plays a role in ciliogenesis coordination, recruits EHD1 to primary cilium where it is anchored to the centriole through interaction with tubulins (By similarity). May indirectly play a role in neurite outgrowth (PubMed:23572513). {ECO:0000250|UniProtKB:Q8N3F8, ECO:0000269|PubMed:23572513}.
uniprot
proteins
mass_dalton
92644
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23572513
uniprot
proteins
sequence_length
855
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000250|UniProtKB:Q8N3F8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8N3F8}. Late endosome membrane {ECO:0000250|UniProtKB:Q8N3F8}. Cell projection, cilium membrane {ECO:0000250|UniProtKB:Q8N3F8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8N3F8}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250|UniProtKB:Q8N3F8}. Note=Localization to late endosomes is actin-dependent. Association to tubular recycling endosomes is regulated by RAB35 and ARF6. Interaction with tubulins achors MICALL1 to the centriole. {ECO:0000250|UniProtKB:Q8N3F8}.
uniprot
proteins