Otud7b
entrez
229603
canonical
uniprot
B2RUR8
canonical
ensembl
ENSMUSG00000038495
resolver
ensp
ENSMUSP00000046413
resolver
ensp
ENSMUSP00000088291
resolver
ensp
ENSMUSP00000096449
resolver
ensp
ENSMUSP00000296655
resolver
ensp
ENSMUSP00000296658
resolver
ensp
ENSMUSP00000296660
resolver
ensp
ENSMUSP00000296665
resolver
ensp
ENSMUSP00000296680
resolver
enst
ENSMUST00000035519
resolver
enst
ENSMUST00000090785
resolver
enst
ENSMUST00000098849
resolver
genesymbol
Otud7b
resolver
uniprot
Q8CFS0
resolver
uniprot_entry
OTU7B_MOUSE
resolver
uniprot_sec
Q8CFS0
resolver
activity_regulation
ACTIVITY REGULATION: Deubiquitinase activity is inhibited following interaction with PARK7. {ECO:0000250|UniProtKB:Q6GQQ9}.
uniprot
proteins
amino_acid_sequence
MTLDMDAVLSDFVRSTGAEPGLARDLLEGKNWDVSAALSDFEQLRQVHAGNLSPPFSGGSTCPKTPEKGGSDREPTRPSRPILQRQDDVIQEKRLSRGISHASSSIVSLARSHVSSNGGGGGSSEHPLEMPICAFQLPDLTVYKEDFRSFIERDLIEQSMLVALEQAGRLNWWVSMDSTCQRLLPLATTGDGNCLLHAASLGMWGFHDRDLVLRKALYALMEKGVEKEALRRRWRWQQTQQNKESGLVYTEDEWQKEWNELIKLASSEPRMHLGSNGASGGGVESSEEPVYESLEEFHVFVLAHVLKRPIVVVADTMLRDSGGEAFAPIPFGGIYLPLEVPASQCHRSPLVLAYDQAHFSALVSMEQKESAKEQAVIPLTDSEHKLLPLHFAVDPGKGWEWGKDDNDNVRLASIILSLEVKLHLLHSYMNVKWIPLSSDSQAPLAQPESPTASAGDEPRSTPESGESDKESVGSSSLGNEGSRRKEKSKRDREKDKKRADSVANKLGSFGKTLGSKLKKNMGGLMHSKGPKPGGLGSGSGISSGTETLEKKKKNNTLKSWKGGKEEAAGDGPVSEKPPSESVGNGGSKYSQEVMQSLSTMRIAMQGEGKYIFVGTLKMGHRHQYQEEMIQRYLADAEERFLAEQKQKEVERKIMNGGLVSGPPPAKKPEPDGGEDQPSDSPAEPKAMAFSTAYPGGFTIPRPSGGGVHCQEPRRQLAGGPCVGGLPSYATFPRQYPGRPYPHQDNIPALEPGKDGVHRGALLPPQFRVADSYSNGYREPPEPDGWAGAPRGLPPTQTKCKQPNCSFYGHPETNNLCSCCYREELRRREREPGGELLAHRF
uniprot
proteins
ec_number
3.4.19.12
uniprot
proteins
function
FUNCTION: Negative regulator of the non-canonical NF-kappa-B pathway that acts by mediating deubiquitination of TRAF3, an inhibitor of the NF-kappa-B pathway, thereby acting as a negative regulator of B-cell responses (PubMed:23334419). In response to non-canonical NF-kappa-B stimuli, deubiquitinates 'Lys-48'-linked polyubiquitin chains of TRAF3, preventing TRAF3 proteolysis and over-activation of non-canonical NF-kappa-B (PubMed:23334419). Negatively regulates mucosal immunity against infections (PubMed:23334419). Deubiquitinates ZAP70, and thereby regulates T cell receptor (TCR) signaling that leads to the activation of NF-kappa-B (PubMed:26903241). Plays a role in T cell homeostasis and is required for normal T cell responses, including production of IFNG and IL2 (PubMed:26903241). Mediates deubiquitination of EGFR (By similarity). Has deubiquitinating activity toward 'Lys-11', 'Lys-48' and 'Lys-63'-linked polyubiquitin chains (By similarity). Has a much higher catalytic rate with 'Lys-11'-linked polyubiquitin chains (in vitro); however the physiological significance of these data are unsure (By similarity). Hydrolyzes both linear and branched forms of polyubiquitin (By similarity). Acts as a regulator of mTORC1 and mTORC2 assembly by mediating 'Lys-63'-linked deubiquitination of MLST8, thereby promoting assembly of the mTORC2 complex, while inhibiting formation of the mTORC1 complex (By similarity). {ECO:0000250|UniProtKB:Q6GQQ9, ECO:0000269|PubMed:23334419, ECO:0000269|PubMed:26903241}.
uniprot
proteins
mass_dalton
91983
uniprot
proteins
mutagenesis
MUTAGEN 194; /note="C->S: Loss of deubiquitinating activity; when associated with R-358."; /evidence="ECO:0000269|PubMed:23334419"; MUTAGEN 358; /note="H->R: Loss of deubiquitinating activity; when associated with S-194."; /evidence="ECO:0000269|PubMed:23334419
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by EGFR. {ECO:0000250|UniProtKB:Q6GQQ9}.
uniprot
proteins
protein_family
Peptidase C64 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23334419
uniprot
proteins
pubmed
26903241
uniprot
proteins
sequence_length
840
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q6GQQ9}. Nucleus {ECO:0000250|UniProtKB:Q6GQQ9}. Note=Shuttles be cytoplasm and the nucleus in a XPO1/CRM1-dependent manner. {ECO:0000250|UniProtKB:Q6GQQ9}.
uniprot
proteins