Fasl
entrez
14103
canonical
uniprot
P41047
canonical
ensembl
ENSMUSG00000000817
resolver
ensp
ENSMUSP00000000834
resolver
genesymbol
Fasl
resolver
genesymbol
Faslg
resolver
genesymbol_syn
Apt1lg1
resolver
genesymbol_syn
Cd95l
resolver
genesymbol_syn
Fasl
resolver
genesymbol_syn
Tnfsf6
resolver
genesymbol_syn
Tnlg1a
resolver
genesymbol_syn
gld
resolver
uniprot
Q544E9
resolver
uniprot
Q61217
resolver
uniprot
Q99PH8
resolver
uniprot
Q9R1F2
resolver
uniprot_entry
Q544E9_MOUSE
resolver
uniprot_entry
Q99PH8_MOUSE
resolver
uniprot_entry
TNFL6_MOUSE
resolver
uniprot_sec
Q61217
resolver
uniprot_sec
Q9R1F2
resolver
amino_acid_sequence
MQQPMNYPCPQIFWVDSSATSSWAPPGSVFPCPSCGPRGPDQRRPPPPPPPVSPLPPPSQPLPLPPLTPLKKKDHNTNLWLPVVFFMVLVALVGMGLGMYQLFHLQKELAELREFTNQSLKVSSFEKQIANPSTPSEKKEPRSVAHLTGNPHSRSIPLEWEDTYGTALISGVKYKKGGLVINETGLYFVYSKVYFRGQSCNNQPLNHKVYMRNSKYPEDLVLMEEKRLNYCTTGQIWAHSSYLGAVFNLTSADHLYVNISQLSLINFEESKTFFGLYKL
uniprot
proteins
disease_involvement
DISEASE: Note=A deficiency in this protein is the cause of generalized lymphoproliferation disease phenotype (gld). Gld mice present lymphadenopathy and autoantibody production. The phenotype is recessively inherited. {ECO:0000269|PubMed:7511063}.
uniprot
proteins
function
FUNCTION: Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:7511063). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed:19794494, PubMed:7532682). Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (PubMed:19794494). TNFRSF6/FAS-mediated apoptosis also has a role in the induction of peripheral tolerance (PubMed:10779162). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis (By similarity). {ECO:0000250|UniProtKB:P48023, ECO:0000269|PubMed:19794494, ECO:0000269|PubMed:7511063, ECO:0000269|PubMed:7532682}.; FUNCTION: [Tumor necrosis factor ligand superfamily member 6, soluble form]: Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways (PubMed:19794494). Can induce apoptosis but does not appear to be essential for this process (By similarity). {ECO:0000250|UniProtKB:P48023, ECO:0000269|PubMed:19794494}.; FUNCTION: [FasL intracellular domain]: Cytoplasmic form induces gene transcription inhibition. {ECO:0000250|UniProtKB:P48023}.
uniprot
proteins
mass_dalton
31442
uniprot
proteins
post_translational_modification
PTM: The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form undergoes two successive intramembrane proteolytic cleavages. The first one is processed by ADAM10 producing an N-terminal fragment, which lacks the receptor-binding extracellular domain. This ADAM10-processed FasL (FAsL APL) remnant form is still membrane anchored and further processed by SPPL2A that liberates the FasL intracellular domain (FasL ICD). FasL shedding by ADAM10 is a prerequisite for subsequent intramembrane cleavage by SPPL2A in T-cells. {ECO:0000250|UniProtKB:P48023}.; PTM: Phosphorylated by FGR on tyrosine residues; this is required for ubiquitination and subsequent internalization. {ECO:0000250|UniProtKB:P48023}.; PTM: N-glycosylated. Glycosylation enhances apoptotic activity. {ECO:0000250|UniProtKB:P48023}.; PTM: Monoubiquitinated. {ECO:0000250|UniProtKB:P48023}.
uniprot
proteins
protein_family
Tumor necrosis factor family
uniprot
proteins
pubmed
10552956
uniprot
proteins
pubmed
10779162
uniprot
proteins
pubmed
19794494
uniprot
proteins
pubmed
7495745
uniprot
proteins
pubmed
7511063
uniprot
proteins
pubmed
7532682
uniprot
proteins
pubmed
7544870
uniprot
proteins
pubmed
7889405
uniprot
proteins
pubmed
9108079
uniprot
proteins
sequence_length
279
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform FasL]: Cell membrane {ECO:0000269|PubMed:19794494, ECO:0000269|PubMed:7532682}; Single-pass type II membrane protein {ECO:0000255}. Cytoplasmic vesicle lumen {ECO:0000250|UniProtKB:P48023}. Lysosome lumen {ECO:0000250|UniProtKB:P48023}. Note=Is internalized into multivesicular bodies of secretory lysosomes after phosphorylation by FGR and monoubiquitination. Colocalizes with the SPPL2A protease at the cell membrane. {ECO:0000250|UniProtKB:P48023}.; SUBCELLULAR LOCATION: [Tumor necrosis factor ligand superfamily member 6, soluble form]: Secreted {ECO:0000269|PubMed:10552956, ECO:0000269|PubMed:19794494}. Note=May be released into the extracellular fluid by cleavage from the cell surface. {ECO:0000250|UniProtKB:P48023}.; SUBCELLULAR LOCATION: [FasL intracellular domain]: Nucleus {ECO:0000250|UniProtKB:P48023}. Note=The FasL ICD cytoplasmic form is translocated into the nucleus. {ECO:0000250|UniProtKB:P48023}.
uniprot
proteins
transmembrane_region
TRANSMEM 79..100; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins