NUDT18
entrez
79873
canonical
uniprot
Q6ZVK8
canonical
ensembl
ENSG00000275074
resolver
ensp
ENSP00000480722
resolver
genesymbol
NUDT18
resolver
genesymbol_syn
MTH3
resolver
hgnc
HGNC:26194
resolver
uniprot
Q8IZ75
resolver
uniprot
Q9H687
resolver
uniprot_entry
NUD18_HUMAN
resolver
uniprot_sec
Q8IZ75
resolver
uniprot_sec
Q9H687
resolver
amino_acid_sequence
MASEGLAGALASVLAGQGSSVHSCDSAPAGEPPAPVRLRKNVCYVVLAVFLSEQDEVLLIQEAKRECRGSWYLPAGRMEPGETIVEALQREVKEEAGLHCEPETLLSVEERGPSWVRFVFLARPTGGILKTSKEADAESLQAAWYPRTSLPTPLRAHDILHLVELAAQYRQQARHPLILPQELPCDLVCQRLVATFTSAQTVWVLVGTVGMPHLPVTACGLDPMEQRGGMKMAVLRLLQECLTLHHLVVEIKGLLGLQHLGRDHSDGICLNVLVTVAFRSPGIQDEPPKVRGENFSWWKVMEEDLQSQLLQRLQGSSVVPVNR
uniprot
proteins
ec_number
3.6.1.58
uniprot
proteins
ec_number
3.6.1.68
uniprot
proteins
ec_number
3.6.1.76
uniprot
proteins
function
FUNCTION: Mediates the hydrolysis of oxidized nucleoside diphosphate derivatives. Hydrolyzes 8-oxo-7,8-dihydroguanine (8-oxo-Gua)-containing deoxyribo- and ribonucleoside diphosphates to the monophosphates. Hydrolyzes 8-oxo-dGDP and 8-oxo-GDP with the same efficiencies. Also hydrolyzes 8-OH-dADP and 2-OH-dADP. Exhibited no or minimal hydrolysis activity against 8-oxo-dGTP, 8-oxo-GTP, dGTP, GTP, dGDP and GDP. Probably removes oxidized guanine nucleotides from both the DNA and RNA precursor pools. In vitro, it catalyzes the hydrolysis of isoprene pyrophosphates, including (2E)-geranyl diphosphate, isopentenyl diphosphate, (2E,6E)-farnesyl diphosphate and dimethylallyl diphosphate (PubMed:38944687). It may therefore play a role in the control of cellular levels of these metabolites that are essential for multiple cellular processes, including isoprenoids synthesis and protein isoprenylation (Probable). {ECO:0000269|PubMed:22556419, ECO:0000269|PubMed:38944687, ECO:0000305|PubMed:38944687}.
uniprot
proteins
mass_dalton
35501
uniprot
proteins
protein_family
Nudix hydrolase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
22556419
uniprot
proteins
pubmed
24352381
uniprot
proteins
pubmed
38944687
uniprot
proteins
sequence_length
323
uniprot
proteins