Dio3
entrez
29475
canonical
uniprot
P49897
canonical
ensembl
ENSRNOG00000052017
resolver
ensembl
ENSRNOG00055031874
resolver
ensembl
ENSRNOG00060028324
resolver
ensembl
ENSRNOG00065029732
resolver
ensp
ENSRNOP00000093110
resolver
ensp
ENSRNOP00055045604
resolver
ensp
ENSRNOP00060041087
resolver
ensp
ENSRNOP00065042289
resolver
enst
ENSRNOT00055055172
resolver
enst
ENSRNOT00060049227
resolver
enst
ENSRNOT00065051353
resolver
genesymbol
Dio3
resolver
genesymbol_syn
Itdi3
resolver
genesymbol_syn
Txdi3
resolver
uniprot_entry
IOD3_RAT
resolver
amino_acid_sequence
MPRQAASRLVVGEGEGPPGASGPAATMLRSLLLHSLRLCAQTASCLVLFPRFLGTAFMLWLLDFLCIRKHFLRRRHPDHPEPEVELNSEGEEMPPDDPPICVSDDNRLCTLASLKAVWHGQKLDFFKQAHEGGPAPNSEVVRPDGFQSQRILDYAQGTRPLVLNFGSCTUPPFMARMSAFQRLVTKYQRDVDFLIIYIEEAHPSDGWVTTDSPYVIPQHRSLEDRVSAARVLQQGAPGCALVLDTMANSSSSAYGAYFERLYVIQSGTIMYQGGRGPDGYQVSELRTWLERYDEQLHGTRPRRL
uniprot
proteins
ec_number
1.21.99.3
uniprot
proteins
function
FUNCTION: Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination. Catalyzes the deiodination of L-thyroxine (T4) to 3,3',5'-triiodothyronine (rT3), 3,5-diiodothyronine (3,5-T2) to 3-monoiodothyronine (3-T1), rT3 to 3',5'-diiodothyronine (3',5'-T2) and 3,3'-diiodothyronine (3,3'-T2) to 3'-monoiodothyronine (3'-T1) via inner-ring deiodination (IRD) (By similarity). Catalyzes the deiodination of 3,5,3'-triiodothyronine (T3) to 3,3'-diiodothyronine (3,3'-T2) via IRD (PubMed:7622463). Catalyzes the deiodination of 3-T1 to L-thyronine (T0) via outer-ring deiodination (ORD) (By similarity). Catalyzes the tyrosyl ring deiodinations of T4AM (3,3',5,5'-tetraiodothyronamine), rT3AM (3,3',5'-triiodothyronamine), T3AM (3,5,3'-triiodothyronamine), 3,5-T2AM (3,5-diiodothyronamine), 3,3'-T2AM (3,3'-diiodothyronamine) and 3-T1AM (3-iodothyronamine) (By similarity). {ECO:0000250|UniProtKB:P55073, ECO:0000269|PubMed:7622463}.
uniprot
proteins
mass_dalton
34096
uniprot
proteins
mutagenesis
MUTAGEN 170; /note="U->L: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:7622463
uniprot
proteins
protein_family
Iodothyronine deiodinase family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
7622463
uniprot
proteins
sequence_length
304
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P55073}; Single-pass type II membrane protein {ECO:0000255}. Endosome membrane {ECO:0000250|UniProtKB:P55073}; Single-pass type II membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 43..62; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins