Nup50
entrez
18141
canonical
uniprot
Q9JIH2
canonical
ensembl
ENSMUSG00000016619
resolver
ensp
ENSMUSP00000131457
resolver
ensp
ENSMUSP00000155656
resolver
ensp
ENSMUSP00000228616
resolver
enst
ENSMUST00000165443
resolver
enst
ENSMUST00000230411
resolver
genesymbol
Nup50
resolver
genesymbol_syn
Npap60
resolver
uniprot
Q3TG43
resolver
uniprot
Q3TN17
resolver
uniprot
Q6P1F4
resolver
uniprot
Q6PAL4
resolver
uniprot
Q8C2Y6
resolver
uniprot
Q9CU02
resolver
uniprot
Q9JK85
resolver
uniprot_entry
NUP50_MOUSE
resolver
uniprot_sec
Q3TG43
resolver
uniprot_sec
Q3TN17
resolver
uniprot_sec
Q6P1F4
resolver
uniprot_sec
Q6PAL4
resolver
uniprot_sec
Q8C2Y6
resolver
uniprot_sec
Q9CU02
resolver
uniprot_sec
Q9JK85
resolver
amino_acid_sequence
MAKRVAEKELTDRNWDEEDEVEEMGTFSVASEEVMKNRAVKKAKRRNVGFESDSGGAFKGFKGLVVPSGGGGFSGFGGSGGKPLEGLTNGNSTDNATPFSNVKTAAEPKAAFGSFAVNGPTTLVDKKISSPKCNNSNQPPSSGPASSTACPGNAYHKQLAGLNCSVRDWIVKHVNTNPLCDLTPIFKDYERYLATIEKQLENGGGSSSESQTDRATAGMEPPSLFGSTKLQQESPFSFHGNKAEDTSEKVEFTAEKKSDAAQGATSASFSFGKKIESSALGSLSSGSLTGFSFSAGSSSLFGKDAAQSKAASSLFSAKASESPAGGGSSECRDGEEEENDEPPKVVVTEVKEEDAFYSKKCKLFYKKDNEFKEKGVGTLHLKPTATQKTQLLVRADTNLGNILLNVLIAPNMPCTRTGKNNVLIVCVPNPPLDEKQPTLPATMLIRVKTSEDADELHKILLEKKDA
uniprot
proteins
function
FUNCTION: Component of the nuclear pore complex that has a direct role in nuclear protein import (PubMed:10811608). Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling (PubMed:16222336). Interacts with regulatory proteins of cell cycle progression including CDKN1B (PubMed:10811608, PubMed:10891500). This interaction is required for correct intracellular transport and degradation of CDKN1B (PubMed:10811608). {ECO:0000269|PubMed:10811608, ECO:0000269|PubMed:10891500, ECO:0000269|PubMed:16222336}.
uniprot
proteins
mass_dalton
49485
uniprot
proteins
pubmed
10811608
uniprot
proteins
pubmed
10891500
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16222336
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
466
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nuclear pore complex. Nucleus membrane {ECO:0000250|UniProtKB:O08587}; Peripheral membrane protein {ECO:0000250|UniProtKB:O08587}; Nucleoplasmic side {ECO:0000250|UniProtKB:O08587}. Note=Localizes to the nucleoplasmic fibrils of the nuclear pore complex. Dissociates from the NPC structure early during prophase of mitosis. Associates with the newly formed nuclear membrane during telophase. In the testis, the localization changes during germ cell differentiation from the nuclear surface in spermatocytes to the whole nucleus (interior) in spermatids and back to the nuclear surface in spermatozoa. {ECO:0000250|UniProtKB:O08587, ECO:0000250|UniProtKB:Q9UKX7}.
uniprot
proteins