FAM83A
entrez
84985
canonical
uniprot
Q86UY5
canonical
ensembl
ENSG00000147689
resolver
ensp
ENSP00000427979
resolver
ensp
ENSP00000428876
resolver
ensp
ENSP00000445218
resolver
ensp
ENSP00000509471
resolver
ensp
ENSP00000581132
resolver
genesymbol
FAM83A
resolver
genesymbol_syn
TSGP
resolver
hgnc
HGNC:28210
resolver
uniprot
Q71HL2
resolver
uniprot
Q8N7I1
resolver
uniprot
Q96I47
resolver
uniprot_entry
FA83A_HUMAN
resolver
uniprot_sec
Q71HL2
resolver
uniprot_sec
Q8N7I1
resolver
uniprot_sec
Q96I47
resolver
amino_acid_sequence
MSRSRHLGKIRKRLEDVKSQWVRPARADFSDNESARLATDALLDGGSEAYWRVLSQEGEVDFLSSVEAQYIQAQAREPPCPPDTLGGAEAGPKGLDSSSLQSGTYFPVASEGSEPALLHSWASAEKPYLKEKSSATVYFQTVKHNNIRDLVRRCITRTSQVLVILMDVFTDVEIFCDILEAANKRGVFVCVLLDQGGVKLFQEMCDKVQISDSHLKNISIRSVEGEIYCAKSGRKFAGQIREKFIISDWRFVLSGSYSFTWLCGHVHRNILSKFTGQAVELFDEEFRHLYASSKPVMGLKSPRLVAPVPPGAAPANGRLSSSSGSASDRTSSNPFSGRSAGSHPGTRSVSASSGPCSPAAPHPPPPPRFQPHQGPWGAPSPQAHLSPRPHDGPPAAVYSNLGAYRPTRLQLEQLGLVPRLTPTWRPFLQASPHF
uniprot
proteins
disease_involvement
DISEASE: Note=SACK1A is considered a proto-oncogene. It is overexpressed in various human tumor types, including breast, lung, testis, ovary and bladder tumors. Elevated expression is associated with elevated tumor grade, decreased overall survival and resistance to several drugs (PubMed:22886303, PubMed:24736947). In cancer cells with SACK1A overexpression, may be important for the activation of RAF1 and phosphoinositide 3-kinase PIK3R1/PIK3R2 regulatory subunit p85, even in the absence of stimulus (PubMed:22886303). In breast cancer cells, interacts with the regulatory subunit p85 of phosphoinositide 3-kinase PIK3R1/PIK3R2; this interaction is increased by EGF treatment (PubMed:22886303). In breast cancer cells, interacts with RAF1; this interaction is increased by EGF treatment and leads to increased RAF1 activation (PubMed:22886303, PubMed:24736947). {ECO:0000269|PubMed:22886303, ECO:0000269|PubMed:24736947}.
uniprot
proteins
function
FUNCTION: Involved in mitochondrial maintenance during adipogenesis. May be acting by playing a role in the maintenance of normal mitochondrial function. {ECO:0000250|UniProtKB:Q8K2P2}.
uniprot
proteins
mass_dalton
47458
uniprot
proteins
post_translational_modification
PTM: Phosphorylated upon EGFR activation in a breast cancer cell line. {ECO:0000269|PubMed:22886303}.
uniprot
proteins
protein_family
SACK1 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
22886303
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24736947
uniprot
proteins
pubmed
29789297
uniprot
proteins
sequence_length
434
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:22886303}. Mitochondrion {ECO:0000250|UniProtKB:Q8K2P2}.
uniprot
proteins