Mecr
entrez
29470
canonical
uniprot
Q9Z311
canonical
ensembl
ENSRNOG00000028047
resolver
ensp
ENSRNOP00000031375
resolver
genesymbol
Mecr
resolver
genesymbol_syn
Nrbf1
resolver
uniprot
F1LPY7
resolver
uniprot_entry
MECR_RAT
resolver
uniprot_sec
F1LPY7
resolver
amino_acid_sequence
MLVSRRLTGARARAPLLASLLEAWCRQGRTTSSYSAFSEPSHVRALVYGNHGDPAKVIQLKNLELTAVEGSDVHVKMLAAPINPSDINMIQGNYGLLPKLPAVGGNEGVGQVIAVGSSVSGLKPGDWVIPANAGLGTWRTEAVFSEEALIGVPKDIPLQSAATLGVNPCTAYRMLVDFEQLQPGDSVIQNASNSGVGQAVIQIASALGLKTINVIRDRPDIKKLTDRLKDLGADYVLTEEELRMPETKNIFKDLPLPRLALNCVGGKSSTELLRHLAPGGTMVTYGGMAKQPVTASVSMLIFKDLKLRGFWLSQWKKNHSPDEFKELILILCNLIRQGQLTAPAWSGIPLQDYQQALEASMKPFVSLKQILTM
uniprot
proteins
ec_number
1.3.1.104
uniprot
proteins
function
FUNCTION: Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Displays a preference for medium-chain over short- and long-chain substrates (By similarity). May provide the octanoyl chain used for lipoic acid biosynthesis, regulating protein lipoylation and mitochondrial respiratory activity particularly in Purkinje cells (By similarity). Involved in iron homeostasis; affecting Fe-S cluster assembly and ceramide metabolism (By similarity). Required for proper morphology and bioenergetic functions of mitochondria (By similarity). Required for maintenance of neurons (By similarity). {ECO:0000250|UniProtKB:Q9BV79, ECO:0000250|UniProtKB:Q9DCS3, ECO:0000250|UniProtKB:Q9V6U9}.
uniprot
proteins
mass_dalton
40327
uniprot
proteins
protein_family
Quinone oxidoreductase subfamily
uniprot
proteins
protein_family
Zinc-containing alcohol dehydrogenase family
uniprot
proteins
pubmed
12654921
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
25031892
uniprot
proteins
pubmed
9795230
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Mitochondrion {ECO:0000269|PubMed:12654921}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:25031892}. Nucleus {ECO:0000269|PubMed:25031892}.
uniprot
proteins