Tmem131l
entrez
229473
canonical
uniprot
Q3U3D7
canonical
ensembl
ENSMUSG00000033767
resolver
ensp
ENSMUSP00000049808
resolver
ensp
ENSMUSP00000141438
resolver
ensp
ENSMUSP00000171232
resolver
ensp
ENSMUSP00000171234
resolver
ensp
ENSMUSP00000171239
resolver
ensp
ENSMUSP00000171240
resolver
ensp
ENSMUSP00000171244
resolver
ensp
ENSMUSP00000171250
resolver
ensp
ENSMUSP00000337708
resolver
enst
ENSMUST00000052342
resolver
genesymbol
Tmem131l
resolver
genesymbol_syn
D930015E06Rik
resolver
genesymbol_syn
Kiaa0922
resolver
uniprot
A0A0B4J1F5
resolver
uniprot
Q6P5E2
resolver
uniprot
Q6PHM5
resolver
uniprot
Q6ZQ24
resolver
uniprot
Q8C2B9
resolver
uniprot
Q8K2U7
resolver
uniprot
Q8R3Y2
resolver
uniprot
Q8R580
resolver
uniprot_entry
A0A0B4J1F5_MOUSE
resolver
uniprot_entry
T131L_MOUSE
resolver
uniprot_sec
Q6P5E2
resolver
uniprot_sec
Q6PHM5
resolver
uniprot_sec
Q6ZQ24
resolver
uniprot_sec
Q8C2B9
resolver
uniprot_sec
Q8K2U7
resolver
uniprot_sec
Q8R3Y2
resolver
uniprot_sec
Q8R580
resolver
amino_acid_sequence
MAGLRRPQSGAYRRTAAAVNLLLGVFQVLLSCCRPGGAQGQAFEPLPNVVELWQAEEGELLLPTQGDSEEDMEEPSQEQSFSDKLFIGKGLHFQPSVLDFGIQFLGHPAAKLLYAYNPSRESEVVVNSVFTAARHFHVPPVHCRVIPAMGKASFRVIFLPTEEGSIESSLFINTSSHGVFSYHVSGVGTRRVSTEGSAEQLPNAYFLLPQVQSIQLSQTQAETTNTSLLRVQLECSLHNKVCQQLKSCSLGSDDALHLEMNIIVAVENSSKQPEENTQALLDHLSIVYVATDESDTSDESAVNMYVLHSGNSLIWIQDIHHFSQKNVLSLQFEPVLLSTSTTNFTKIASFTCKAGTSCDSGIMGLRKKKASPAMQACLSSPVVQGYFRTDASTAQFHIESHETATGVWSIWYRSHFDQSIVLKDVFVSKETKHILKVLSFRGPLFLPPGCWNIFSLKLAVKGIVLNLFTNVFLTTNTGAIFAIPLQIFSAPTKEGSLGFEVLAHCGMHYFMGKSKTENPNWERSLSLDRSTWDMDSELANKLYERWKKYKSGDACRRNVLGMSQFAFTKKSKETEPFVSFLPRVVPEPNLVLNFSATALRNSAVKYFVVRNPTPQPVSLQLLPLSLYPRPEAAVRLLHKWFGTDMQMVNLSTGEFQLTQACPYQGEPSEESSLGALHVHLQALETRRVGVVFTPADYGKVTSLILIRNNLTVVDMVGVEGFGAQELLKVGGRLPGAGGSLRFKVPESTLMDCHRQLKDSKQILSITKNFKVENIGPLPITVTSLKINGYNCQGYGFEVLDCHPFSLSPNTSRDISIVFTPDFTSSWVIRELTLVTAADLEFHFTLNVTLPHHMLPLCAEVVPGPSWEESFWRLTVFFVSLSLLGVILIAFQQAQYILMEFMKTRQRQNGSSSSQQNGDPVAMISSHPHKSTCKNFLDTYSPSDKGRGKSCLPVGPSLSRLQNAAKRSPATYGHSQKKHKCSFYYSKQKPSASAASSANVTTEEKQTVTLASSLSVAKEDICTNVLSENWVSLRYASGINGSLQKNLTLPKNVLHKEESSLKNTVVTNTPSECSMKEGVHTYMFPKETDSKISENVAELKEQEPCPQKTSKKPPESTLPKTPPQYLQSDLPEVSRKHGNKQQAPVRSEVDSFEPVRAADAEPSSVRKTQGASPEDTCSEKQDTPSAEQEDPSRKRKLQERREGSTQALNWNKTRPCRRNKKRASAQASSSPRPSEQSEQRLVCSDVRSWCAQDGAGEKCKAGTEVSGSSPERREEDSYYQKSEKKCADKFCSDSSSDCGSSSGSVRASRGSWGSWSSSSSDCDRRPVVDIQHFLPPGDGVSPQNFPSEASVPLSLPQHVCSSTDVSVLPEFTESPCPGLPATPAGAGEEKGLYPPGGLWPSQPVCLTSSFNCPVENGAPGVSQEPTSIPDSSFIDWSASCEGQFPSVYCPLELNDYNAFPEENMNYTNGFPCSSKVQTDFIGHSTPSTWNTPASMPAAWGHASLVNSPSYLTSTRSLSPMSGLFGSIWAPQSEVYETCCPISPATEHATHMENQVMCKEYYLGFNPFRAYMNLDIWTSTANRNANFPLSRDSSYCGNM
uniprot
proteins
function
FUNCTION: In its membrane-associated form, antagonizes canonical Wnt signaling by triggering lysosome-dependent degradation of Wnt-activated LRP6. Regulates thymocyte proliferation. {ECO:0000250|UniProtKB:A2VDJ0}.
uniprot
proteins
mass_dalton
175772
uniprot
proteins
protein_family
TMEM131 family
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1597
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:A2VDJ0}; Single-pass type I membrane protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000250|UniProtKB:A2VDJ0}. Cytoplasm {ECO:0000250|UniProtKB:A2VDJ0}. Note=During intrathymic development, resides in punctate cytoplasmic structures in DN1 and DN2 cells. In DN3 cells, found in large crescent-shaped membrane structures, which preferentially localize in cell-to-cell contact zones. {ECO:0000250|UniProtKB:A2VDJ0}.
uniprot
proteins
transmembrane_region
TRANSMEM 870..890; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins