TKTL1
entrez
8277
canonical
uniprot
P51854
canonical
ensembl
ENSG00000007350
resolver
ensp
ENSP00000358928
resolver
ensp
ENSP00000358931
resolver
genesymbol
TKTL1
resolver
genesymbol_syn
TKR
resolver
genesymbol_syn
TKT2
resolver
hgnc
HGNC:11835
resolver
uniprot
A8K896
resolver
uniprot
B7Z7I0
resolver
uniprot
Q5TYJ8
resolver
uniprot
Q5TYJ9
resolver
uniprot
Q8TC75
resolver
uniprot_entry
B7Z7I0_HUMAN
resolver
uniprot_entry
TKTL1_HUMAN
resolver
uniprot_sec
A8K896
resolver
uniprot_sec
Q5TYJ8
resolver
uniprot_sec
Q5TYJ9
resolver
uniprot_sec
Q8TC75
resolver
amino_acid_sequence
MADAEARAEFPEEARPDRGTLQVLQDMASRLRIHSIRATCSTSSGHPTSCSSSSEIMSVLFFYIMRYKQSDPENPDNDRFVLAKRLSFVDVATGWLGQGLGVACGMAYTGKYFDRASYRVFCLMSDGESSEGSVWEAMAFASYYSLDNLVAIFDVNRLGHSGALPAEHCINIYQRRCEAFGWNTYVVDGRDVEALCQVFWQASQVKHKPTAVVAKTFKGRGTPSIEDAESWHAKPMPRERADAIIKLIESQIQTSRNLDPQPPIEDSPEVNITDVRMTSPPDYRVGDKIATRKACGLALAKLGYANNRVVVLDGDTRYSTFSEIFNKEYPERFIECFMAEQNMVSVALGCASRGRTIAFASTFAAFLTRAFDHIRIGGLAESNINIIGSHCGVSVGDDGASQMALEDIAMFRTIPKCTIFYPTDAVSTEHAVALAANAKGMCFIRTTRPETMVIYTPQERFEIGQAKVLRHCVSDKVTVIGAGITVYEALAAADELSKQDIFIRVIDLFTIKPLDVATIVSSAKATEGRIITVEDHYPQGGIGEAVCAAVSMDPDIQVHSLAVSGVPQSGKSEELLDMYGISARHIIVAVKCMLLN
uniprot
proteins
ec_number
2.2.1.1
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate (By similarity). Thus, catalyzes the reversible transfer of a two-carbon ketol group from sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate, producing xylulose-5-phosphate and ribose-5-phosphate (By similarity). The phosphate group of the substrate plays a role in stabilizing the substrate-thiamine intermediate while preventing the formation of the reactive enamine intermediate (By similarity). Can also use fructose-6-phosphate as a ketose donor (By similarity). {ECO:0000250|UniProtKB:P29401}.; FUNCTION: [Isoform 4]: During fetal neocortex development, may be essential to maintain the full number of basal radial glia (bRG). bRG are neural progenitor cells that undergo asymmetric divisions, generating a bRG (self-renewal) and a neuron, in contrast to basal intermediate progenitors (bIPs), which typically divide once to give rise to 2 neurons. bRG generate more cortical neurons over time than bIPs. {ECO:0000269|PubMed:36074851}.
uniprot
proteins
mass_dalton
65333
uniprot
proteins
protein_family
Transketolase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
15991799
uniprot
proteins
pubmed
36074851
uniprot
proteins
pubmed
8838793
uniprot
proteins
sequence_length
596
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:15991799}.
uniprot
proteins