Prickle2
entrez
243548
canonical
uniprot
Q80Y24
canonical
ensembl
ENSMUSG00000030020
resolver
ensp
ENSMUSP00000032093
resolver
ensp
ENSMUSP00000109072
resolver
ensp
ENSMUSP00000109073
resolver
ensp
ENSMUSP00000109074
resolver
ensp
ENSMUSP00000245818
resolver
enst
ENSMUST00000032093
resolver
enst
ENSMUST00000113445
resolver
enst
ENSMUST00000113446
resolver
enst
ENSMUST00000113447
resolver
genesymbol
Prickle2
resolver
uniprot
A6H652
resolver
uniprot
A7YQ68
resolver
uniprot
F8WJB5
resolver
uniprot_entry
A7YQ68_MOUSE
resolver
uniprot_entry
F8WJB5_MOUSE
resolver
uniprot_entry
PRIC2_MOUSE
resolver
uniprot_sec
A6H652
resolver
amino_acid_sequence
MVTVMPLEMEKTISKLMFDFQRSSTSDDDSGCALEEYAWVPPGLKPEQVHQYYSCLPEEKVPYVNSAGEKLRIKQLLHQLPPHDNEVRYCNSLDEEEKRELKLFSNQRKRENLGRGNVRPFPVTMTGAICEQCGGQIKGGDIAVFASRAGHGICWHPPCFVCTVCNELLVDLIYFYQDGKIYCGRHHAECLKPRCAACDEIIFADECTEAEGRHWHMRHFCCFECETVLGGQRYIMKEGRPYCCHCFESLYAEYCDTCAQHIGIDQGQMTYDGQHWHATETCFCCAHCKKSLLGRPFLPKQGQIFCSRACSAGEDPNGSDSSDSAFQNARAKESRRSAKIGKNKGKTEEAMLNQHSQLQVSSNRLSADVDPLSVQMDLLSLSSQTPSLNRDPIWRSREEPFHYGNKMEQNQSQSPLQLLSQCNIRTSYSPGGQGAGAQPDMWAKHFSNPKRSSSMALKGHGGSFIQECREDYYPGRLMSQESYSDMSSQSFNETRGSIPVPKYEEEEEEEEGGISTQQCRPRRPLSSLKYTEDMTPTEQTPRGSMESLALSNATGLSAEGGAKRQEHLSRFSMPDLSKDSGMNVSEKLSNMGTLNSSMQFRSAESVRSLLSAQQYQEMEGNLHQLSNPLGYRDLQSHGRMHQSFDFDGGIASSKLPGQEGVHIQPMSERTRRRTTSRDDNRRFRPHRSRRSRRSRSDNALHLASEREVIARLKERPPLRAREDYDQFMRQRSFQESLGQGSRRDLYSQCPRTVSDLALQNAFGERWGPYFTEYDWCSTCSSSSESDNEGYFLGEPIPQPARLRYVTSDELLHKYSSYGVPKSSTLGGRGQLHSRKRQKSKNCIIS
uniprot
proteins
function
FUNCTION: Is involved in the organization and maintenance of axon initial segment (AIS) cytoskeletal architecture, likely cooperating with IGSF9B to regulate ANK3/ANKG localization to AIS (PubMed:32641624). By binding to and regulating ANK3/ANKG, it modulates its ability to bundle microtubules, a crucial mechanism for establishing neuronal polarity and AIS formation (By similarity). During early embryonic development, has a role in blastocyst formation, likely controlling the redistribution of the microtubule network during embryo compaction and the establishment of apical/basal cell polarity (PubMed:22333836). {ECO:0000250|UniProtKB:A6IBC5, ECO:0000269|PubMed:22333836, ECO:0000269|PubMed:32641624}.
uniprot
proteins
mass_dalton
95781
uniprot
proteins
protein_family
Prickle / espinas / testin family
uniprot
proteins
pubmed
12525887
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21276947
uniprot
proteins
pubmed
22333836
uniprot
proteins
pubmed
32641624
uniprot
proteins
sequence_length
845
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic density {ECO:0000250|UniProtKB:A6IBC5}. Cell projection, axon {ECO:0000269|PubMed:32641624}. Cell projection, dendrite {ECO:0000269|PubMed:32641624}. Nucleus {ECO:0000269|PubMed:22333836}. Note=In the axon, strongly expressed in the axon initial segment (AIS) (By similarity). Detected in the nucleus of 2-cell-stage till 16-cell-stage embryos; nuclear expression decreases from the 16-cell stage onwards (PubMed:22333836). {ECO:0000250|UniProtKB:A6IBC5, ECO:0000269|PubMed:22333836}.
uniprot
proteins