Abcc3
entrez
140668
canonical
uniprot
O88563
canonical
ensembl
ENSRNOG00000002948
resolver
ensp
ENSRNOP00000069018
resolver
enst
ENSRNOT00000085451
resolver
genesymbol
Abcc3
resolver
genesymbol_syn
Cmoat2
resolver
genesymbol_syn
Mlp2
resolver
genesymbol_syn
Mrp3
resolver
uniprot
A0A0G2JU97
resolver
uniprot
O88270
resolver
uniprot_entry
A0A0G2JU97_RAT
resolver
uniprot_entry
MRP3_RAT
resolver
uniprot_sec
O88270
resolver
amino_acid_sequence
MDRLCGSGELGSKFWDSNLTVYTNTPDLTPCFQNSLLAWVPCIYLWAALPCYLFYLRHHRLGYIVLSCLSRLKTALGVLLWCISWVDLFYSFHGLVHGSSPAPVFFITPLLVGITMLLATLLIQYERLRGVRSSGVLIIFWLLCVICAIIPFRSKILLALAEGKILDPFRFTTFYIYFALVLCAFILSCFQEKPPLFSPENLDTNPCPEASAGFFSRLSFWWFTKLAILGYRRPLEDSDLWSLSEEDCSHKVVQRLLEAWQKQQTQASGPQTAALEPKIAGEDEVLLKARPKTKKPSFLRALVRTFTSSLLMGACFKLIQDLSPSSTHSCSASSSGLFRPHGPYWWGFLLAGLMFVSSTMQTLILHQHYHCIFVMALRIRTAIIGVIYRKALTITNSVKREYTVGEMVNLMSVDAQRFMDVSPFINLLWSAPLQVILAIYFLWQILGPSALAGVAVIVLLIPLNGAVSMKMKTYQVQQMKFKDSRIKLMSEILNGIKVLKLYAWEPTFLEQVEGIRQGELQLLRKGAYLQAISTFIWVCTPFMVTLITLGVYVCVDKNNVLDAEKAFVSLSLFNILKIPLNLLPQLISGMTQTSVSLKRIQDFLNQDELDPQCVERKTISPGRAITIHNGTFSWSKDLPPTLHSINIQIPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGAVSVKGSVAYVPQQAWIQNCTLQENVLFGQPMNPKRYQQALETCALLADLDVLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDANIFLLDDPLSAVDSHVAKHIFDQVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQITEMGHYSELLQHDGSFANFLRNYAPDENQEANEGVLQHANEEVLLLEDTLSTHTDLTDTEPAIYEVRKQFMREMSSLSSEGEGQNRPVLKRYTSSLEKEVPATQTKETGALIKEEIAETGNVKLSVYWDYAKSVGLCTTLFICLLYAGQNAVAIGANVWLSAWTNDVEEHGQQNNTSVRLGVYATLGILQGLLVMLSAFTMVVGAIQAARLLHTALLHNQIRAPQSFFDTTPSGRILNRFSKDIYVIHEVLAPTILMLFNSFYTSISTIVVIVASTPLFCVVVLPLAVFYGFVQRFYVATSRQLKRLESVSRSPIFSHFSETVTGTSVIRAYGRVQDFKVLSDAKVDSNQKTTYPYIASNRWLGVHVEFVGNCVVLFSALFAVIGRNSLNPGLVGLSVSYALQVTLSLNWMIRTLSDLESNIIAVERVKEYSKTETEAPWVLESNRAPEGWPRSGVVEFRNYSVRYRPGLELVLKNLTLHVQGGEKVGIVGRTGAGKSSMTLCLFRILEAAEGEIFIDGLNVAHIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGRYSDEDIWRTLELSHLSAFVSSQPTGLDFQCSEGGDNLSVGQRQLVCLARALLRKSRVLVLDEATAAIDLETDDLIQGTIRTQFEDCTVLTIAHRLNTIMDYNRVLVLDKGVVAEFDSPVNLIAAGGIFYGMAKDAGLA
uniprot
proteins
ec_number
7.6.2.-
uniprot
proteins
ec_number
7.6.2.2
uniprot
proteins
ec_number
7.6.2.3
uniprot
proteins
function
FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyzes ATP to enable active transport of substrates conjugated with glucuronate, glutathione or sulfate. Operates at basolateral membranes of polarized cells such as hepatocytes and intestinal epithelial cells, where it mediates the efflux of conjugated substrates from intestine and liver into the bloodstream (By similarity). Involved in enterohepatic recirculation of steroid glucuronates. Shares substrate specificity with MRP2, displaying higher affinity for both estrogen and androgen glucuronates such as 17beta-estradiol, estrone, testosterone and 5alpha-dihydrotestosterone glucuronates (By similarity). Involved in sinusoidal efflux of mono- and bis-glucuronidated bilirubin from hepatocytes into the blood for renal uptake and excretion (By similarity). May selectively transport steroid sulfate conjugates. Has transporter activity toward androgen sulfates such as androsterone and dehydroepiandrosterone sulfates but is inactive toward estrone 3-sulfate (By similarity). Can transport various bile acid conjugates such as taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate and taurolithocholate-3-sulfate. Does not contribute substantially to bile acids physiology, but provides an alternative route for the export of bile acids and glucuronate conjugates from cholestatic hepatocytes to avoid liver damage (By similarity) (PubMed:10644759). Can transport glutathione conjugates such as leukotriene C4 (LTC4) (By similarity). Transports various xenobiotics. Confers resistance to anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells. May contribute to the transport of organic compounds in testes across the blood-testis-barrier (By similarity). {ECO:0000250|UniProtKB:B2RX12, ECO:0000250|UniProtKB:O15438, ECO:0000269|PubMed:10644759}.
uniprot
proteins
mass_dalton
168978
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCC family
uniprot
proteins
protein_family
Conjugate transporter (TC 3.A.1.208) subfamily
uniprot
proteins
pubmed
10362653
uniprot
proteins
pubmed
10644759
uniprot
proteins
pubmed
11897632
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9614210
uniprot
proteins
sequence_length
1522
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:11897632}; Multi-pass membrane protein {ECO:0000255}. Basal cell membrane {ECO:0000250|UniProtKB:O15438}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 38..54; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 73..89; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 107..122; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 134..148; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 172..189; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 315..329; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 351..365; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 429..442; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 448..463; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 530..547; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 567..582; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 963..983; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1011..1027; /note="Helical; Name=13"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1083..1099; /note="Helical; Name=14"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1106..1118; /note="Helical; Name=15"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1191..1206; /note="Helical; Name=16"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441"; TRANSMEM 1223..1238; /note="Helical; Name=17"; /evidence="ECO:0000250|UniProtKB:O15438, ECO:0000255|PROSITE-ProRule:PRU00441
uniprot
proteins