ENTPD8
entrez
377841
canonical
uniprot
Q5MY95
canonical
ensembl
ENSG00000188833
resolver
ensp
ENSP00000344089
resolver
ensp
ENSP00000360561
resolver
genesymbol
ENTPD8
resolver
hgnc
HGNC:24860
resolver
uniprot
A2BG17
resolver
uniprot
Q6UVZ0
resolver
uniprot_entry
ENTP8_HUMAN
resolver
uniprot_sec
A2BG17
resolver
uniprot_sec
Q6UVZ0
resolver
activity_regulation
ACTIVITY REGULATION: Not inhibited by ARL 67156 (PubMed:17603550). ADP hydrolase activity is inhibited by high concentrations (5-10 mM) of azide with the greatest inhibition (80-90%) obtained at pH 6.4 using MgADP as the substrate (PubMed:16752921). ATP hydrolase activity is inhibited by several detergents as well as benzyl alcohol (PubMed:16752921). {ECO:0000269|PubMed:16752921, ECO:0000269|PubMed:17603550}.
uniprot
proteins
amino_acid_sequence
MGLSRKEQVFLALLGASGVSGLTALILLLVEATSVLLPTDIKFGIVFDAGSSHTSLFLYQWLANKENGTGVVSQALACQVEGPGISSYTSNAAQAGESLQGCLEEALVLIPEAQHRKTPTFLGATAGMRLLSRKNSSQARDIFAAVTQVLGRSPVDFWGAELLAGQAEGAFGWITVNYGLGTLVKYSFTGEWIQPPEEMLVGALDMGGASTQITFVPGGPILDKSTQADFRLYGSDYSVYTHSYLCFGRDQMLSRLLVGLVQSRPAALLRHPCYLSGYQTTLALGPLYESPCVHATPPLSLPQNLTVEGTGNPGACVSAIRELFNFSSCQGQEDCAFDGVYQPPLRGQFYAFSNFYYTFHFLNLTSRQPLSTVNATIWEFCQRPWKLVEASYPGQDRWLRDYCASGLYILTLLHEGYGFSEETWPSLEFRKQAGGVDIGWTLGYMLNLTGMIPADAPAQWRAESYGVWVAKVVFMVLALVAVVGAALVQLFWLQD
uniprot
proteins
ec_number
3.6.1.5
uniprot
proteins
function
FUNCTION: Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity (PubMed:17095758). Catalyzes the hydrolysis of nucleoside triphosphates (NTPs) and diphosphates (NDPs) (PubMed:16752921, PubMed:17095758, PubMed:17603550). The enzyme sequentially removes phosphate groups in two successive steps, converting NTPs to nucleoside monophosphates (NMPs) via NDP intermediates (PubMed:16752921, PubMed:17095758, PubMed:17603550). This activity contributes to the regulation of extracellular levels of nucleotides (PubMed:16752921, PubMed:17095758, PubMed:17603550). Hydrolyzes ATP, UTP, ADP, and UDP and prefers triphosphonucleosides and adenine over uracil as substrates (PubMed:17095758). Does not hydrolyzes AMP (PubMed:17095758). {ECO:0000269|PubMed:16752921, ECO:0000269|PubMed:17095758, ECO:0000269|PubMed:17603550}.
uniprot
proteins
mass_dalton
53904
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:16752921}.
uniprot
proteins
protein_family
GDA1/CD39 NTPase family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16752921
uniprot
proteins
pubmed
17095758
uniprot
proteins
pubmed
17603550
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
495
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q5DRK1}; Multi-pass membrane protein {ECO:0000255}. Note=Localized in the canalicular membrane vesicle. {ECO:0000250|UniProtKB:Q5DRK1}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 472..492; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins