AGAP2
entrez
116986
canonical
uniprot
Q99490
canonical
ensembl
ENSG00000135439
resolver
ensp
ENSP00000257897
resolver
ensp
ENSP00000328160
resolver
ensp
ENSP00000449241
resolver
genesymbol
AGAP2
resolver
genesymbol_syn
CENTG1
resolver
genesymbol_syn
KIAA0167
resolver
hgnc
HGNC:16921
resolver
uniprot
A8K9F7
resolver
uniprot
F8VVT9
resolver
uniprot
O00578
resolver
uniprot
Q548E0
resolver
uniprot
Q8IWU3
resolver
uniprot_entry
AGAP2_HUMAN
resolver
uniprot_sec
A8K9F7
resolver
uniprot_sec
F8VVT9
resolver
uniprot_sec
O00578
resolver
uniprot_sec
Q548E0
resolver
uniprot_sec
Q8IWU3
resolver
activity_regulation
ACTIVITY REGULATION: GAP activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and, to a lesser extent, by phosphatidylinositol 3,4,5-trisphosphate (PIP3). Phosphatidic acid potentiates PIP2 stimulation.
uniprot
proteins
amino_acid_sequence
MSRGAGALQRRTTTYLISLTLVKLESVPPPPPSPSAAAAGAAGARGSETGDPGSPRGAEEPGKKRHERLFHRQDALWISTSSAGTGGAEPPALSPAPASPARPVSPAPGRRLSLWAVPPGPPLSGGLSPDPKPGGAPTSSRRPLLSSPSWGGPEPEGRAGGGIPGSSSPHPGTGSRRLKVAPPPPAPKPCKTVTTSGAKAGGGKGAGSRLSWPESEGKPRVKGSKSSAGTGASVSAAATAAAAGGGGSTASTSGGVGAGAGARGKLSPRKGKSKTLDNSDLHPGPPAGSPPPLTLPPTPSPATAVTAASAQPPGPAPPITLEPPAPGLKRGREGGRASTRDRKMLKFISGIFTKSTGGPPGSGPLPGPPSLSSGSGSRELLGAELRASPKAVINSQEWTLSRSIPELRLGVLGDARSGKSSLIHRFLTGSYQVLEKTESEQYKKEMLVDGQTHLVLIREEAGAPDAKFSGWADAVIFVFSLEDENSFQAVSRLHGQLSSLRGEGRGGLALALVGTQDRISASSPRVVGDARARALCADMKRCSYYETCATYGLNVDRVFQEVAQKVVTLRKQQQLLAACKSLPSSPSHSAASTPVAGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGSLHRAAKRRTSLFANRRGSDSEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGPSASINGLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPSGDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEAKRKMWKLKSFGSLRNIYKAEENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGEGGSAATTPSAATTPSITATPSPRRRSSAASVGRADAPVALV
uniprot
proteins
function
FUNCTION: GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. {ECO:0000269|PubMed:12640130, ECO:0000269|PubMed:14761976, ECO:0000269|PubMed:15118108, ECO:0000269|PubMed:16079295}.
uniprot
proteins
mass_dalton
124591
uniprot
proteins
post_translational_modification
PTM: Isoform PIKE-A is phosphorylated at Tyr-682 and Tyr-774 by FYN, preventing its apoptotic cleavage. {ECO:0000269|PubMed:16841086}.
uniprot
proteins
protein_family
Centaurin gamma-like family
uniprot
proteins
pubmed
12640130
uniprot
proteins
pubmed
14528310
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14761976
uniprot
proteins
pubmed
15118108
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16079295
uniprot
proteins
pubmed
16150119
uniprot
proteins
pubmed
16263930
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
16841086
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17037982
uniprot
proteins
pubmed
18371979
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
8724849
uniprot
proteins
pubmed
9192850
uniprot
proteins
sequence_length
1192
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Nucleus.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm.
uniprot
proteins