Ctsk
entrez
13038
canonical
uniprot
P55097
canonical
ensembl
ENSMUSG00000028111
resolver
ensp
ENSMUSP00000015664
resolver
enst
ENSMUST00000015664
resolver
genesymbol
Ctsk
resolver
uniprot
O88718
resolver
uniprot
Q545T0
resolver
uniprot_entry
CATK_MOUSE
resolver
uniprot_entry
Q545T0_MOUSE
resolver
uniprot_sec
O88718
resolver
amino_acid_sequence
MWVFKFLLLPMVSFALSPEEMLDTQWELWKKTHQKQYNSKVDEISRRLIWEKNLKQISAHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLRIPPSRSYSNDTLYTPEWEGRVPDSIDYRKKGYVTPVKNQGQCGSCWAFSSAGALEGQLKKKTGKLLALSPQNLVDCVTENYGCGGGYMTTAFQYVQQNGGIDSEDAYPYVGQDESCMYNATAKAAKCRGYREIPVGNEKALKRAVARVGPISVSIDASLASFQFYSRGVYYDENCDRDNVNHAVLVVGYGTQKGSKHWIIKNSWGESWGNKGYALLARNKNNACGITNMASFPKM
uniprot
proteins
ec_number
3.4.22.38
uniprot
proteins
function
FUNCTION: Thiol protease involved in osteoclastic bone resorption. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation (By similarity). Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (PubMed:12782676). {ECO:0000250, ECO:0000269|PubMed:12782676}.
uniprot
proteins
mass_dalton
36889
uniprot
proteins
protein_family
Peptidase C1 family
uniprot
proteins
pubmed
10372556
uniprot
proteins
pubmed
12782676
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8814310
uniprot
proteins
sequence_length
329
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:12782676}. Secreted {ECO:0000269|PubMed:12782676}. Apical cell membrane {ECO:0000269|PubMed:12782676}; Peripheral membrane protein {ECO:0000269|PubMed:12782676}; Extracellular side {ECO:0000269|PubMed:12782676}. Note=Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells. {ECO:0000269|PubMed:12782676}.
uniprot
proteins