DOC2A
entrez
8448
canonical
uniprot
Q14183
canonical
ensembl
ENSG00000149927
resolver
ensp
ENSP00000340017
resolver
ensp
ENSP00000455624
resolver
ensp
ENSP00000482870
resolver
ensp
ENSP00000604610
resolver
ensp
ENSP00000604617
resolver
ensp
ENSP00000640518
resolver
genesymbol
DOC2A
resolver
hgnc
HGNC:2985
resolver
uniprot
B4DEJ2
resolver
uniprot
H3BNH6
resolver
uniprot
Q6P4G4
resolver
uniprot
Q7Z5G0
resolver
uniprot
Q8IVX0
resolver
uniprot_entry
DOC2A_HUMAN
resolver
uniprot_sec
B4DEJ2
resolver
uniprot_sec
H3BNH6
resolver
uniprot_sec
Q6P4G4
resolver
uniprot_sec
Q7Z5G0
resolver
uniprot_sec
Q8IVX0
resolver
amino_acid_sequence
MRGRRGDRMTINIQEHMAINVCPGPIRPIRQISDYFPRGPGPEGGGGGGGEAPAHLVPLALAPPAALLGATTPEDGAEVDSYDSDDATALGTLEFDLLYDRASCTLHCSILRAKGLKPMDFNGLADPYVKLHLLPGACKANKLKTKTQRNTLNPVWNEDLTYSGITDDDITHKVLRIAVCDEDKLSHNEFIGEIRVPLRRLKPSQKKHFNICLERQVPLASPSSMSAALRGISCYLKELEQAEQGQGLLEERGRILLSLSYSSRRRGLLVGILRCAHLAAMDVNGYSDPYVKTYLRPDVDKKSKHKTCVKKKTLNPEFNEEFFYEIELSTLATKTLEVTVWDYDIGKSNDFIGGVSLGPGARGEARKHWSDCLQQPDAALERWHTLTSELPPAAGALSSA
uniprot
proteins
function
FUNCTION: Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. {ECO:0000269|PubMed:18354201, ECO:0000269|PubMed:9736751, ECO:0000269|PubMed:9804756}.
uniprot
proteins
mass_dalton
43959
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
18354201
uniprot
proteins
pubmed
7826360
uniprot
proteins
pubmed
8554557
uniprot
proteins
pubmed
9736751
uniprot
proteins
pubmed
9804756
uniprot
proteins
sequence_length
400
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Synapse, synaptosome.
uniprot
proteins