TAF13
entrez
6884
canonical
uniprot
Q15543
canonical
ensembl
ENSG00000197780
resolver
ensp
ENSP00000355051
resolver
enst
ENST00000338366
resolver
genesymbol
TAF13
resolver
genesymbol_syn
TAF2K
resolver
genesymbol_syn
TAFII18
resolver
hgnc
HGNC:11546
resolver
uniprot
B2R5E5
resolver
uniprot
Q5TYV6
resolver
uniprot_entry
TAF13_HUMAN
resolver
uniprot_sec
B2R5E5
resolver
uniprot_sec
Q5TYV6
resolver
amino_acid_sequence
MADEEEDPTFEEENEEIGGGAEGGQGKRKRLFSKELRCMMYGFGDDQNPYTESVDILEDLVIEFITEMTHKAMSIGRQGRVQVEDIVFLIRKDPRKFARVKDLLTMNEELKRARKAFDEANYGS
uniprot
proteins
disease_involvement
DISEASE: Intellectual developmental disorder, autosomal recessive 60 (MRT60) [MIM:617432]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT60 patients display mild intellectual disability, delayed psychomotor development, learning difficulties, and poor overall growth with variable microcephaly. {ECO:0000269|PubMed:28257693}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473, PubMed:9695952). TFIID recognizes and binds promoters via its subunit TBP, a TATA-box-binding protein, and promotes assembly of the pre-initiation complex (PIC) (PubMed:33795473). The TFIID complex consists of TBP and TBP-associated factors (TAFs), including TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13 (PubMed:33795473). TAF13, together with TAF11 and TBP, play key roles during promoter binding by the TFIID and TFIIA transcription factor complexes (PubMed:33795473). {ECO:0000269|PubMed:33795473, ECO:0000269|PubMed:9695952}.
uniprot
proteins
mass_dalton
14287
uniprot
proteins
protein_family
TAF13 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
28257693
uniprot
proteins
pubmed
33795473
uniprot
proteins
pubmed
7729427
uniprot
proteins
pubmed
9695952
uniprot
proteins
sequence_length
124
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9695952}.
uniprot
proteins