ARHGAP22
entrez
58504
canonical
uniprot
Q7Z5H3
canonical
ensembl
ENSG00000128805
resolver
ensp
ENSP00000249601
resolver
ensp
ENSP00000363285
resolver
ensp
ENSP00000363287
resolver
ensp
ENSP00000410054
resolver
ensp
ENSP00000412461
resolver
ensp
ENSP00000416701
resolver
ensp
ENSP00000538930
resolver
ensp
ENSP00000725384
resolver
ensp
ENSP00000783185
resolver
genesymbol
ARHGAP22
resolver
genesymbol_syn
RHOGAP2
resolver
hgnc
HGNC:30320
resolver
uniprot
A0AVP7
resolver
uniprot
A5YM75
resolver
uniprot
B4DED8
resolver
uniprot
B9EGA0
resolver
uniprot
C9JDM2
resolver
uniprot
O00152
resolver
uniprot
Q6ZSB0
resolver
uniprot_entry
RHG22_HUMAN
resolver
uniprot_sec
A0AVP7
resolver
uniprot_sec
A5YM75
resolver
uniprot_sec
B4DED8
resolver
uniprot_sec
B9EGA0
resolver
uniprot_sec
C9JDM2
resolver
uniprot_sec
O00152
resolver
uniprot_sec
Q6ZSB0
resolver
amino_acid_sequence
MLSPKIRQARRARSKSLVMGEQSRSPGRMPCPHRLGPVLKAGWLKKQRSIMKNWQQRWFVLRGDQLFYYKDKDEIKPQGFISLQGTQVTELPPGPEDPGKHLFEISPGGAGEREKVPANPEALLLMASSQRDMEDWVQAIRRVIWAPLGGGIFGQRLEETVHHERKYGPRLAPLLVEQCVDFIRERGLTEEGLFRMPGQANLVRDLQDSFDCGEKPLFDSTTDVHTVASLLKLYLRELPEPVVPFARYEDFLSCAQLLTKDEGEGTLELAKQVSNLPQANYNLLRYICKFLDEVQAYSNVNKMSVQNLATVFGPNILRPQVEDPVTIMEGTSLVQHLMTVLIRKHSQLFTAPVPEGPTSPRGGLQCAVGWGSEEVTRDSQGEPGGPGLPAHRTSSLDGAAVAVLSRTAPTGPGSRCSPGKKVQTLPSWKSSFRQPRSLSGSPKGGGSSLEVPIISSGGNWLMNGLSSLRGHRRASSGDRLKDSGSVQRLSTYDNVPAPGLVPGIPSVASMAWSGASSSESSVGGSLSSCTACRASDSSARSSLHTDWALEPSPLPSSSEDPKSLDLDHSMDEAGAGASNSEPSEPDSPTREHARRSEALQGLVTELRAELCRQRTEYERSVKRIEEGSADLRKRMSRLEEELDQEKKKYIMLEIKLRNSERAREDAERRNQLLQREMEEFFSTLGSLTVGAKGARAPK
uniprot
proteins
function
FUNCTION: Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
76779
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15254788
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
698
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Mainly cytoplasmic. Some fraction is nuclear (By similarity). {ECO:0000250}.
uniprot
proteins