TNIK
entrez
23043
canonical
uniprot
Q9UKE5
canonical
ensembl
ENSG00000154310
resolver
ensp
ENSP00000284483
resolver
ensp
ENSP00000345352
resolver
ensp
ENSP00000349880
resolver
ensp
ENSP00000399511
resolver
ensp
ENSP00000418156
resolver
ensp
ENSP00000418378
resolver
ensp
ENSP00000418916
resolver
ensp
ENSP00000419990
resolver
genesymbol
TNIK
resolver
genesymbol_syn
KIAA0551
resolver
hgnc
HGNC:30765
resolver
uniprot
A7E2A3
resolver
uniprot
A8K4U1
resolver
uniprot
D3DNQ6
resolver
uniprot
O60298
resolver
uniprot
Q8WUY7
resolver
uniprot
Q9UKD8
resolver
uniprot
Q9UKD9
resolver
uniprot
Q9UKE0
resolver
uniprot
Q9UKE1
resolver
uniprot
Q9UKE2
resolver
uniprot
Q9UKE3
resolver
uniprot
Q9UKE4
resolver
uniprot_entry
TNIK_HUMAN
resolver
uniprot_sec
A7E2A3
resolver
uniprot_sec
A8K4U1
resolver
uniprot_sec
D3DNQ6
resolver
uniprot_sec
O60298
resolver
uniprot_sec
Q8WUY7
resolver
uniprot_sec
Q9UKD8
resolver
uniprot_sec
Q9UKD9
resolver
uniprot_sec
Q9UKE0
resolver
uniprot_sec
Q9UKE1
resolver
uniprot_sec
Q9UKE2
resolver
uniprot_sec
Q9UKE3
resolver
uniprot_sec
Q9UKE4
resolver
amino_acid_sequence
MASDSPARSLDEIDLSALRDPAGIFELVELVGNGTYGQVYKGRHVKTGQLAAIKVMDVTGDEEEEIKQEINMLKKYSHHRNIATYYGAFIKKNPPGMDDQLWLVMEFCGAGSVTDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRTVGRRNTFIGTPYWMAPEVIACDENPDATYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLIPRNPAPRLKSKKWSKKFQSFIESCLVKNHSQRPATEQLMKHPFIRDQPNERQVRIQLKDHIDRTKKKRGEKDETEYEYSGSEEEEEENDSGEPSSILNLPGESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEHKRQLLAERQKRIEEQKEQRRRLEEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQLLHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQRPVEKKPLYHYKEGMSPSEKPAWAKEVEERSRLNRQSSPAMPHKVANRISDPNLPPRSESFSISGVQPARTPPMLRPVDPQIPHLVAVKSQGPALTASQSVHEQPTKGLSGFQEALNVTSHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWLRQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPILESPLQRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPHEPAKVKPEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPMKKVTDYSSSSEESESSEEEEEDGESETHDGTVAVSDIPRLIPTGAPGSNEQYNVGMVGTHGLETSHADSFSGSISREGTLMIRETSGEKKRSGHSDSNGFAGHINLPDLVQQSHSPAGTPTEGLGRVSTHSQEMDSGTEYGMGSSTKASFTPFVDPRVYQTSPTDEDEEDEESSAAALFTSELLRQEQAKLNEARKISVVNVNPTNIRPHSDTPEIRKYKKRFNSEILCAALWGVNLLVGTENGLMLLDRSGQGKVYNLINRRRFQQMDVLEGLNVLVTISGKKNKLRVYYLSWLRNRILHNDPEVEKKQGWITVGDLEGCIHYKVVKYERIKFLVIALKNAVEIYAWAPKPYHKFMAFKSFADLQHKPLLVDLTVEEGQRLKVIFGSHTGFHVIDVDSGNSYDIYIPSHIQGNITPHAIVILPKTDGMEMLVCYEDEGVYVNTYGRITKDVVLQWGEMPTSVAYIHSNQIMGWGEKAIEIRSVETGHLDGVFMHKRAQRLKFLCERNDKVFFASVRSGGSSQVFFMTLNRNSMMNW
uniprot
proteins
disease_involvement
DISEASE: Intellectual developmental disorder, autosomal recessive 54 (MRT54) [MIM:617028]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT54 patients manifest intellectual disability, delayed speech and hyperactivity. {ECO:0000269|PubMed:27106596}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway (PubMed:26437443). {ECO:0000269|PubMed:10521462, ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19061864, ECO:0000269|PubMed:19816403, ECO:0000269|PubMed:20159449, ECO:0000269|PubMed:21690388, ECO:0000269|PubMed:26437443}.
uniprot
proteins
mass_dalton
154943
uniprot
proteins
mutagenesis
MUTAGEN 54; /note="K->A: Kinase dead. Loss of autophosphorylation and loss of function in cytoskeleton regulation."; /evidence="ECO:0000269|PubMed:15342639, ECO:0000269|PubMed:19816403"; MUTAGEN 152..153; /note="RD->AA: Loss of autophosphorylation."; /evidence="ECO:0000269|PubMed:19816403"; MUTAGEN 171..172; /note="DF->AA: Loss of autophosphorylation."; /evidence="ECO:0000269|PubMed:19816403
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. Autophosphorylation is activated by RAP2A and induces association to the cytoskeletal fraction.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
protein_family
STE20 subfamily
uniprot
proteins
pubmed
10521462
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15342639
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
18930710
uniprot
proteins
pubmed
19061864
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19816403
uniprot
proteins
pubmed
20159449
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21690388
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26437443
uniprot
proteins
pubmed
27106596
uniprot
proteins
pubmed
9628581
uniprot
proteins
sequence_length
1360
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Recycling endosome. Cytoplasm, cytoskeleton. Note=Associated with recycling endosomes and the cytoskeletal fraction upon RAP2A overexpression.
uniprot
proteins