RNFT1
entrez
51136
canonical
uniprot
Q5M7Z0
canonical
ensembl
ENSG00000189050
resolver
ensp
ENSP00000304670
resolver
genesymbol
RNFT1
resolver
hgnc
HGNC:30206
resolver
uniprot
Q8N7D0
resolver
uniprot
Q96IZ9
resolver
uniprot
Q9Y686
resolver
uniprot_entry
RNFT1_HUMAN
resolver
uniprot_sec
Q8N7D0
resolver
uniprot_sec
Q96IZ9
resolver
uniprot_sec
Q9Y686
resolver
amino_acid_sequence
MPLFLLSLPTPPSASGHERRQRPEAKTSGSEKKYLRAMQANRSQLHSPPGTGSSEDASTPQCVHTRLTGEGSCPHSGDVHIQINSIPKECAENASSRNIRSGVHSCAHGCVHSRLRGHSHSEARLTDDTAAESGDHGSSSFSEFRYLFKWLQKSLPYILILSVKLVMQHITGISLGIGLLTTFMYANKSIVNQVFLRERSSKIQCAWLLVFLAGSSVLLYYTFHSQSLYYSLIFLNPTLDHLSFWEVFWIVGITDFILKFFFMGLKCLILLVPSFIMPFKSKGYWYMLLEELCQYYRTFVPIPVWFRYLISYGEFGNVTRWSLGILLALLYLILKLLEFFGHLRTFRQVLRIFFTQPSYGVAASKRQCSDVDDICSICQAEFQKPILLICQHIFCEECMTLWFNREKTCPLCRTVISDHINKWKDGATSSHLQIY
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. {ECO:0000269|PubMed:27485036}.
uniprot
proteins
mass_dalton
49710
uniprot
proteins
mutagenesis
MUTAGEN 375; /note="C->S: Decreased ubiquitin ligase activity; when associated with S-378."; /evidence="ECO:0000269|PubMed:27485036"; MUTAGEN 378; /note="C->S: Decreased ubiquitin ligase activity; when associated with S-375."; /evidence="ECO:0000269|PubMed:27485036
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:27485036}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17074343
uniprot
proteins
pubmed
27485036
uniprot
proteins
sequence_length
435
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:27485036}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 158..178; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 203..223; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 233..253; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 256..276; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 298..318; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 323..343; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins