CENPC
entrez
1060
canonical
uniprot
Q03188
canonical
ensembl
ENSG00000145241
resolver
ensp
ENSP00000273853
resolver
ensp
ENSP00000580863
resolver
ensp
ENSP00000751001
resolver
genesymbol
CENPC
resolver
genesymbol_syn
CENPC1
resolver
genesymbol_syn
ICEN7
resolver
hgnc
HGNC:1854
resolver
uniprot
Q6PIR0
resolver
uniprot
Q8IW27
resolver
uniprot
Q9P0M5
resolver
uniprot_entry
CENPC_HUMAN
resolver
uniprot_sec
Q6PIR0
resolver
uniprot_sec
Q8IW27
resolver
uniprot_sec
Q9P0M5
resolver
amino_acid_sequence
MAASGLDHLKNGYRRRFCRPSRARDINTEQGQNVLEILQDCFEEKSLANDFSTNSTKSVPNSTRKIKDTCIQSPSKECQKSHPKSVPVSSKKKEASLQFVVEPSEATNRSVQAHEVHQKILATDVSSKNTPDSKKISSRNINDHHSEADEEFYLSVGSPSVLLDAKTSVSQNVIPSSAQKRETYTFENSVNMLPSSTEVSVKTKKRLNFDDKVMLKKIEIDNKVSDEEDKTSEGQERKPSGSSQNRIRDSEYEIQRQAKKSFSTLFLETVKRKSESSPIVRHAATAPPHSCPPDDTKLIEDEFIIDESDQSFASRSWITIPRKAGSLKQRTISPAESTALLQGRKSREKHHNILPKTLANDKHSHKPHPVETSQPSDKTVLDTSYALIGETVNNYRSTKYEMYSKNAEKPSRSKRTIKQKQRRKFMAKPAEEQLDVGQSKDENIHTSHITQDEFQRNSDRNMEEHEEMGNDCVSKKQMPPVGSKKSSTRKDKEESKKKRFSSESKNKLVPEEVTSTVTKSRRISRRPSDWWVVKSEESPVYSNSSVRNELPMHHNSSRKSTKKTNQSSKNIRKKTIPLKRQKTATKGNQRVQKFLNAEGSGGIVGHDEISRCSLSEPLESDEADLAKKKNLDCSRSTRSSKNEDNIMTAQNVPLKPQTSGYTCNIPTESNLDSGEHKTSVLEESGPSRLNNNYLMSGKNDVDDEEVHGSSDDSKQSKVIPKNRIHHKLVLPSNTPNVRRTKRTRLKPLEYWRGERIDYQGRPSGGFVISGVLSPDTISSKRKAKENIGKVNKKSNKKRICLDNDERKTNLMVNLGIPLGDPLQPTRVKDPETREIILMDLVRPQDTYQFFVKHGELKVYKTLDTPFFSTGKLILGPQEEKGKQHVGQDILVFYVNFGDLLCTLHETPYILSTGDSFYVPSGNYYNIKNLRNEESVLLFTQIKR
uniprot
proteins
function
FUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions. {ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}.
uniprot
proteins
mass_dalton
106834
uniprot
proteins
protein_family
CENP-C/MIF2 family
uniprot
proteins
pubmed
1339310
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16622419
uniprot
proteins
pubmed
16716197
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17651496
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19482874
uniprot
proteins
pubmed
19503796
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21529714
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24522885
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
27499292
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
9645950
uniprot
proteins
sequence_length
943
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17651496}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:17651496, ECO:0000269|PubMed:19482874, ECO:0000269|PubMed:21529714}. Chromosome, centromere {ECO:0000269|PubMed:9645950}. Note=Localizes exclusively in the kinetochore domain of centromeres. {ECO:0000269|PubMed:21529714}.
uniprot
proteins