MARK4
entrez
57787
canonical
uniprot
Q96L34
canonical
ensembl
ENSG00000007047
resolver
ensp
ENSP00000262891
resolver
ensp
ENSP00000300843
resolver
ensp
ENSP00000536259
resolver
genesymbol
MARK4
resolver
genesymbol_syn
KIAA1860
resolver
genesymbol_syn
MARKL1
resolver
hgnc
HGNC:13538
resolver
uniprot
Q8NG37
resolver
uniprot
Q96JG7
resolver
uniprot
Q96SQ2
resolver
uniprot
Q9BYD8
resolver
uniprot_entry
MARK4_HUMAN
resolver
uniprot_sec
Q8NG37
resolver
uniprot_sec
Q96JG7
resolver
uniprot_sec
Q96SQ2
resolver
uniprot_sec
Q9BYD8
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation on Thr-214. {ECO:0000269|PubMed:14976552}.
uniprot
proteins
amino_acid_sequence
MSSRTVLAPGNDRNSDTHGTLGSGRSSDKGPSWSSRSLGARCRNSIASCPEEQPHVGNYRLLRTIGKGNFAKVKLARHILTGREVAIKIIDKTQLNPSSLQKLFREVRIMKGLNHPNIVKLFEVIETEKTLYLVMEYASAGEVFDYLVSHGRMKEKEARAKFRQIVSAVHYCHQKNIVHRDLKAENLLLDAEANIKIADFGFSNEFTLGSKLDTFCGSPPYAAPELFQGKKYDGPEVDIWSLGVILYTLVSGSLPFDGHNLKELRERVLRGKYRVPFYMSTDCESILRRFLVLNPAKRCTLEQIMKDKWINIGYEGEELKPYTEPEEDFGDTKRIEVMVGMGYTREEIKESLTSQKYNEVTATYLLLGRKTEEGGDRGAPGLALARVRAPSDTTNGTSSSKGTSHSKGQRSSSSTYHRQRRHSDFCGPSPAPLHPKRSPTSTGEAELKEERLPGRKASCSTAGSGSRGLPPSSPMVSSAHNPNKAEIPERRKDSTSTPNNLPPSMMTRRNTYVCTERPGAERPSLLPNGKENSSGTPRVPPASPSSHSLAPPSGERSRLARGSTIRSTFHGGQVRDRRAGGGGGGGVQNGPPASPTLAHEAAPLPAGRPRPTTNLFTKLTSKLTRRVADEPERIGGPEVTSCHLPWDQTETAPRLLRFPWSVKLTSSRPPEALMAALRQATAAARCRCRQPQPFLLACLHGGAGGPEPLSHFEVEVCQLPRPGLRGVLFRRVAGTALAFRTLVTRISNDLEL
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase (PubMed:14594945, PubMed:15009667, PubMed:23184942, PubMed:23666762). Phosphorylates the microtubule-associated protein MAPT/TAU (PubMed:14594945, PubMed:23666762). Also phosphorylates the microtubule-associated proteins MAP2 and MAP4 (PubMed:14594945). Involved in regulation of the microtubule network, causing reorganization of microtubules into bundles (PubMed:14594945, PubMed:25123532). Required for the initiation of axoneme extension during cilium assembly (PubMed:23400999). Regulates the centrosomal location of ODF2 and phosphorylates ODF2 in vitro (PubMed:23400999). Plays a role in cell cycle progression, specifically in the G1/S checkpoint (PubMed:25123532). Reduces neuronal cell survival (PubMed:15009667). Plays a role in energy homeostasis by regulating satiety and metabolic rate (By similarity). Promotes adipogenesis by activating JNK1 and inhibiting the p38MAPK pathway, and triggers apoptosis by activating the JNK1 pathway (By similarity). Phosphorylates mTORC1 complex member RPTOR and acts as a negative regulator of the mTORC1 complex, probably due to disruption of the interaction between phosphorylated RPTOR and the RRAGA/RRAGC heterodimer which is required for mTORC1 activation (PubMed:23184942). Involved in NLRP3 positioning along microtubules by mediating NLRP3 recruitment to microtubule organizing center (MTOC) upon inflammasome activation (PubMed:28656979). {ECO:0000250|UniProtKB:Q8CIP4, ECO:0000269|PubMed:14594945, ECO:0000269|PubMed:15009667, ECO:0000269|PubMed:23184942, ECO:0000269|PubMed:23400999, ECO:0000269|PubMed:23666762, ECO:0000269|PubMed:25123532, ECO:0000269|PubMed:28656979}.
uniprot
proteins
mass_dalton
82520
uniprot
proteins
mutagenesis
MUTAGEN 214; /note="T->A: Prevents phosphorylation and activation by STK11/LKB1 complex."; /evidence="ECO:0000269|PubMed:14976552"; MUTAGEN 214; /note="T->E: Mimicks phosphorylation state, leading to increased activity. Decreases mTORC1 activity."; /evidence="ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:23184942
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated with 'Lys-29'- and 'Lys-33'-linked polyubiquitins which appear to impede LKB1-mediated phosphorylation. Deubiquitinated by USP9X. {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:18254724}.; PTM: Phosphorylated at Thr-214 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39 (PubMed:14976552). Phosphorylated throughout the cell cycle (PubMed:25123532). {ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:25123532}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
SNF1 subfamily
uniprot
proteins
pubmed
11326310
uniprot
proteins
pubmed
11347906
uniprot
proteins
pubmed
14594945
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14976552
uniprot
proteins
pubmed
15009667
uniprot
proteins
pubmed
16959763
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18254724
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
23184942
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23400999
uniprot
proteins
pubmed
23666762
uniprot
proteins
pubmed
25123532
uniprot
proteins
pubmed
28656979
uniprot
proteins
sequence_length
752
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:14594945}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:14594945, ECO:0000269|PubMed:28656979}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:23400999}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:23400999}. Cytoplasm {ECO:0000269|PubMed:23400999, ECO:0000269|PubMed:23666762}. Cell projection, dendrite {ECO:0000269|PubMed:23666762}. Note=Localized at the tips of neurite-like processes in differentiated neuroblast cells. Detected in the cytoplasm and neuropil of the hippocampus. {ECO:0000269|PubMed:14594945, ECO:0000269|PubMed:23666762}.
uniprot
proteins