Ncapd2
entrez
68298
canonical
uniprot
Q8K2Z4
canonical
ensembl
ENSMUSG00000038252
resolver
ensp
ENSMUSP00000042260
resolver
ensp
ENSMUSP00000302480
resolver
enst
ENSMUST00000043848
resolver
genesymbol
Ncapd2
resolver
genesymbol_syn
Capd2
resolver
genesymbol_syn
Cnap1
resolver
genesymbol_syn
Kiaa0159
resolver
uniprot
A0A0R4J0H7
resolver
uniprot
Q6ZQI1
resolver
uniprot
Q8R0F2
resolver
uniprot
Q8R3H0
resolver
uniprot
Q922B7
resolver
uniprot
Q923A3
resolver
uniprot
Q9CS25
resolver
uniprot
Q9CT32
resolver
uniprot_entry
A0A0R4J0H7_MOUSE
resolver
uniprot_entry
CND1_MOUSE
resolver
uniprot_sec
Q6ZQI1
resolver
uniprot_sec
Q8R0F2
resolver
uniprot_sec
Q8R3H0
resolver
uniprot_sec
Q922B7
resolver
uniprot_sec
Q923A3
resolver
uniprot_sec
Q9CS25
resolver
uniprot_sec
Q9CT32
resolver
amino_acid_sequence
MSPHNFEFHLPLSPEELLKSGGVNQYVVREVLPVKHLSSQLRAFQSAFRAQGPLAILEHFDTVYSILHHFRSIEPGLKEDTLEFLKKVVSRHSQELSSILDDAALSGSDRSAHLNALKMNCYALIRLLESFENMTSQTSLIDLDIGGKGKRARAKATLGFDWEEERQPVLQLLTQLLQLDIRHLWNHSAIEEEFVSLVTGCCYRLLENPTISHQKNRSTKEAIAHLLGVALVRYNHMLSATVKIIQMLQHFEHLPPVLVTAVSLWATDYGMKSIVGEIVREIGQKCPQELSRDTAGAKGFAAFLTELAERIPAVLMANMCILLDHLDGENYMMRNAVLAAIAEMVLQVLNGDQLEESARETRDQFLDILQAHGHDVNSFVRSRVLQLFARIVQQKALPLTRFQAVVALAVGRLADKSVLVCKNAIQLLASFLANNPFSCKLSDIDLAGPLQKEIQKLQEMRAQRRSAAATAALDPEEEWDAMLPELKSTLQQLLKLPQEEGDHQIADAETAEEVKGRIRQLLAKASYKQAIVLTREATSHFQESEPFSHTEPEENSFLNLLGLIFKGPEASTQDSHGDTDPGLTGSKDSPSVPEPEGSQSNDELVKQEMLVQYLQDAYGFSQKITEAIGIISKMMYENTTTVVQEVIEFFVMVFQFGVPQALFGVRRMLPLIWSKEPGVREAVLNAYRQLYLNPKGDSARAKAQTLIHNLSLLLVDASVGTIQCLEEILCEFVQKDEVKPAVIQLLWERATEKVPSSPLERCSSVMLLGMMARGKPEIVGSNLDALVRVGLDEKSPQDYRLAQQVCLAIANISDRRKPSLGERHPPFRLPQEHRLFERLQDMVTKGFAHPDPLWIPFKEVAVTLTYQLAESPDVLCAQMLQGCAKQVLEKLEKNATEADPKETAPRLPTFLLMNLLSLAGDVALQQLVHLEQAVSGELGRRRVLREEQEHRAKEPKEKTASSETTMEEELGLVGGATADDTEAELIRSICEKELLDGNQVLAAFVPLLLKVCNNPGLYSNPELCAAASLALGKFCMISAPFCDSQLRLLFTMLEKSSLPTVRSNLMVATGDLAIRFPNLVDPWTPHLYARLRDPAQQVRKTAGLVMTHLILKDMVKVKGQVSEMAVLLIDPVPQIAALAKNFFNELSHKGNAIYNLLPDIISRLSDPEGGVEEEPFHTIMKQLLSYITKDKQTESLVEKLCQRFRTARTERQYRDLAYCMSQLPLTERGLQKMLDNFECFGDKLLDESVFSAFLSIVGKLRRGAKPEGKAIIDEFEQKLRACHTRGMDGIEEFETGQGGSQRALSAKKPSAVSRLQPLTSVDSDNDFVTPKPRRTKPGRPQTQQRKKSQRKAKVVFLSDESSEDELSAEMTEEETPKRTTPIRRASGRRHRS
uniprot
proteins
function
FUNCTION: Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size. {ECO:0000250|UniProtKB:Q15021}.
uniprot
proteins
mass_dalton
155665
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPH and NCAPG subunits, activates the condensin complex and is required for chromosome condensation (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
CND1 (condensin subunit 1) family
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1392
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Chromosome {ECO:0000250}. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase (By similarity). {ECO:0000250}.
uniprot
proteins