Tubg2
entrez
103768
canonical
uniprot
Q8VCK3
canonical
ensembl
ENSMUSG00000045007
resolver
ensp
ENSMUSP00000045901
resolver
enst
ENSMUST00000043654
resolver
genesymbol
Tubg2
resolver
genesymbol_syn
tubg2
resolver
uniprot
Q6F4J0
resolver
uniprot_entry
Q6F4J0_MOUSE
resolver
uniprot_entry
TBG2_MOUSE
resolver
amino_acid_sequence
MPREIITLQLGQCGNQIGFEFWKQLCAEHGISPEGIVEEFATEGTDRKDVFFYQADDEHYIPRAVLLDLEPRVIHSILNSSYAKLYNPENIYLSEHGGGAGNNWGRGFSQGEKIHEDIFDIIDREADGSDSLEGFVLCHSIAGGTGSGLGSYLLERLNDRYPKKLVQTYSVFPNQDEMSDVVVQPYNSLLTLKRLTQNADCVVVLDNTALNRIATDRLHIQNPSFSQINQLVSTIMSASTTTLRYPGYMNNDLIGLIASLIPTPRLHFLMTGYTPLTTDQSVASVRKTTVLDVMRRLLQPKNVMVSTGRDRQTNHCYIAILNIIQGEVDPTQVHKSLQRIRERKLANFIPWGPASIQVALSRKSPYLPSAHRVSGLMMANHTSISSLFESSCQQYDKLWKRGAFLEQFRKEDIFKDNFEEMHRSREVVQELIDEYHAATRPDYISWGTQEQ
uniprot
proteins
function
FUNCTION: Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers (By similarity). Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation (By similarity). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (By similarity). {ECO:0000250|UniProtKB:Q9NRH3}.
uniprot
proteins
mass_dalton
51122
uniprot
proteins
mutagenesis
MUTAGEN 131; /note="S->A: Weak effect possibly due to low expression of this mutant."; /evidence="ECO:0000269|PubMed:19648910"; MUTAGEN 131; /note="S->D: Phosphomimetic mutant that lead to increased centrosome number."; /evidence="ECO:0000269|PubMed:19648910
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-131 by BRSK1 regulates centrosome duplication, possibly by mediating relocation of gamma-tubulin and its associated proteins from the cytoplasm to the centrosome. {ECO:0000269|PubMed:19648910}.
uniprot
proteins
protein_family
Tubulin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19648910
uniprot
proteins
sequence_length
451
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:19648910}. Note=Mainly localizes to the centrosome, but a fraction is found outside of the centrosome in the cytoplasm.
uniprot
proteins