Gde1
entrez
60418
canonical
uniprot
Q9JL55
canonical
ensembl
ENSRNOG00000050445
resolver
ensembl
ENSRNOG00055006855
resolver
ensembl
ENSRNOG00060018475
resolver
ensembl
ENSRNOG00065029675
resolver
ensp
ENSRNOP00000064735
resolver
ensp
ENSRNOP00055008846
resolver
ensp
ENSRNOP00060025826
resolver
ensp
ENSRNOP00065042198
resolver
enst
ENSRNOT00055011274
resolver
enst
ENSRNOT00060031796
resolver
enst
ENSRNOT00065051259
resolver
genesymbol
Gde1
resolver
genesymbol_syn
Mir16
resolver
uniprot
Q6IRJ6
resolver
uniprot_entry
GDE1_RAT
resolver
uniprot_sec
Q6IRJ6
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by EDTA, calcium chloride, and zinc chloride. Enhanced by magnesium chloride (By similarity). Glycerophosphodiester phosphodiesterase activity can be modulated by G-protein signaling pathways (PubMed:12576545). {ECO:0000250|UniProtKB:Q9JL56, ECO:0000269|PubMed:12576545}.
uniprot
proteins
amino_acid_sequence
MWLWEDQGGLLGPFSFVLVLLLVVTRSPFNACVLTGSLYLLLRFFSFEPVPSRRALQVLKPRDRVSAIAHRGGSHDAPENTLAAIRQAAKNGATGVELDIEFTSDGVPVLMHDNTVDRTTDGSGRLCDLTFEQVRKLNPAANHRLRNEFPDERIPTLREAVTECLCHNLTIFFDVKGHADMASAALKNIYMEFPQLYNNSMVCSFLPEVIYKMRQTDQKVITALTHRPWSLSHTGDGKPRYSVFWKQSVFVVLDILLDWSMHNVLWYLCGISAFLMQKDFVSPDYLKKWSAKGIQVVSWTVNTFDEKNYYESHLGSSYITDSMLEDCAPHF
uniprot
proteins
ec_number
3.1.4.-
uniprot
proteins
ec_number
3.1.4.44
uniprot
proteins
function
FUNCTION: Hydrolyzes the phosphodiester bond of glycerophosphodiesters such as glycerophosphoinositol (GroPIns) and glycerophosphoethanolamine (GroPEth), to yield a glycerol phosphate and an alcohol (PubMed:12576545). Hydrolyzes glycerophospho-N-acylethanolamines to N-acylethanolamines in the brain and participates in bioactive N-acylethanolamine biosynthesis such as anandamide (an endocannabinoid), N-palmitoylethanolamine (an anti-inflammatory), and N-oleoylethanolamine (an anorexic). In addition, has a lysophospholipase D activity by hydrolyzing N-acyl-lysoplasmenylethanolamine (N-acyl-lysoPlsEt) to N-acylethanolamine. However lysophospholipase D activity is lower than glycerophosphodiester phosphodiesterase activity (By similarity). Has little or no activity towards glycerophosphocholine (PubMed:12576545). {ECO:0000250|UniProtKB:Q9JL56, ECO:0000269|PubMed:12576545}.
uniprot
proteins
mass_dalton
37634
uniprot
proteins
mutagenesis
MUTAGEN 97; /note="E->A: Strongly reduced activity; when associated with A-99."; /evidence="ECO:0000269|PubMed:12576545"; MUTAGEN 99; /note="D->A: Strongly reduced activity; when associated with A-97."; /evidence="ECO:0000269|PubMed:12576545"; MUTAGEN 112; /note="H->A: Loss of activity."; /evidence="ECO:0000269|PubMed:12576545
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:10760272}.
uniprot
proteins
protein_family
Glycerophosphoryl diester phosphodiesterase family
uniprot
proteins
pubmed
10760272
uniprot
proteins
pubmed
12576545
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
331
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10760272, ECO:0000269|PubMed:12576545}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:10760272, ECO:0000269|PubMed:12576545}; Multi-pass membrane protein {ECO:0000255}. Note=Perinuclear vesicles and cell membrane. {ECO:0000305|PubMed:12576545}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 249..269; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins