ALKBH7
entrez
84266
canonical
uniprot
Q9BT30
canonical
ensembl
ENSG00000125652
resolver
ensp
ENSP00000245812
resolver
enst
ENST00000245812
resolver
genesymbol
ALKBH7
resolver
genesymbol_syn
ABH7
resolver
genesymbol_syn
SPATA11
resolver
hgnc
HGNC:21306
resolver
uniprot
B2R4U9
resolver
uniprot
Q53FF3
resolver
uniprot_entry
ALKB7_HUMAN
resolver
uniprot_sec
B2R4U9
resolver
uniprot_sec
Q53FF3
resolver
amino_acid_sequence
MAGTGLLALRTLPGPSWVRGSGPSVLSRLQDAAVVRPGFLSTAEEETLSRELEPELRRRRYEYDHWDAAIHGFRETEKSRWSEASRAILQRVQAAAFGPGQTLLSSVHVLDLEARGYIKPHVDSIKFCGATIAGLSLLSPSVMRLVHTQEPGEWLELLLEPGSLYILRGSARYDFSHEILRDEESFFGERRIPRGRRISVICRSLPEGMGPGESGQPPPAC
uniprot
proteins
ec_number
1.14.11.-
uniprot
proteins
function
FUNCTION: RNA demethylase that demethylates N(2)-dimethylguanosine and N(1)-methyladenosine within mitochondrial pre-tRNA regions. This demethylation activity plays a crucial role in regulating the processing of nascent polycistronic mitochondrial RNA, thereby influencing mitochondrial gene expression and overall mitochondrial activity (PubMed:34253897). In response to extensive DNA damage is required for programmed necrosis induced by alkylation and oxidation. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death (PubMed:23666923). Involved in fatty acid metabolism (By similarity). {ECO:0000250|UniProtKB:Q9D6Z0, ECO:0000269|PubMed:23666923, ECO:0000269|PubMed:34253897}.
uniprot
proteins
mass_dalton
24516
uniprot
proteins
mutagenesis
MUTAGEN 110; /note="L->Q: Does not affect ability to trigger programmed necrosis."; /evidence="ECO:0000269|PubMed:23666923
uniprot
proteins
protein_family
AlkB family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17979886
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23666923
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25122757
uniprot
proteins
pubmed
34253897
uniprot
proteins
sequence_length
221
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:23666923}.
uniprot
proteins