Chd1l
entrez
68058
canonical
uniprot
Q9CXF7
canonical
ensembl
ENSMUSG00000028089
resolver
ensp
ENSMUSP00000029730
resolver
ensp
ENSMUSP00000272051
resolver
ensp
ENSMUSP00000334975
resolver
ensp
ENSMUSP00000334984
resolver
genesymbol
Chd1l
resolver
uniprot
Q3TMX1
resolver
uniprot
Q6P5C0
resolver
uniprot_entry
CHD1L_MOUSE
resolver
uniprot_sec
Q3TMX1
resolver
uniprot_sec
Q6P5C0
resolver
activity_regulation
ACTIVITY REGULATION: Adopts an inactive conformation in absence of DNA damage. Binding to poly-ADP-ribosylated histones activates the ATP-dependent chromatin remodeler activity. {ECO:0000250|UniProtKB:Q86WJ1}.
uniprot
proteins
amino_acid_sequence
MASGLPRFLQALPAEHGPEPLRTRVQEPDLQQWGLTGIRLRSYQLEGVNWLVQCFHCQNGCILGDEMGLGKTCQTIALLIYLVGRLNDEGPFLVLCPLSVLSNWKEEMERFAPGLSCVTYTGDKEERARLQQDLRQESGFHVLLTTYEICLKDASFLKSFSWSVLAVDEAHRLKNQSSLLHRTLSEFSAVFRLLLTGTPIQNSLRELYSLLCVVEPDLFCREQVEDFVQRYQDIEKESKSASELHRLLQPFLLRRVKAQVATELPKKTEVVVYHGMSALQKKYYKAILMKDLDAFENETAKKVKLQNILTQLRKCVDHPYLFDGVEPEPFEVGEHLIEASGKLHLLDRLLAFLYSGGHRVLLFSQMTHMLDILQDYMDYRGYSYERVDGSVRGEERHLAIKNFGNQPIFVFLLSTRAGGVGMNLTAADTVIFVDSDFNPQNDLQAAARAHRIGQNKSVKVIRLIGRDTVEEIVYRKAASKLQLTNMVIEGGHFTPGAQKPSAEADFQLSEILKFGLDKLLSSEGSSMEDIDLKSILGETKDGQWTPDALPAAAAAGGGSLEPEEGSELESRSYENHMYLFEGRDYSKEPSKEDRKSFEQLVNLQKTLLEKTSHGGRTLRNKGSVLIPGLAEGPIKRKKILSPEELEDRRKKRQEAAAKRKRLMEEKRKEKEEAEHRKKMAWWESNGYQSFCLSSEDSELEDLEGGDESSAELAYEDLDSTSINYVSGDVTHPQAGEEDAVIVHCVDDSGRWGRGGLFTALEVRSAEPRKIYELAGKMEDLSLGDVLLFPIDDKESRDKGQDLLALVVAQHRDRTNVLSGIKMAALEEGLKKIFLAAKKKKASVHLPRIGHATKGFNWYGTERLIRKHLATRGIPTYIYYFPRSKARHSQPASSSSAPLVP
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage. Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage. Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair. Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner. Chromatin remodeling activity promotes PARP2 removal from chromatin. {ECO:0000250|UniProtKB:Q86WJ1}.
uniprot
proteins
mass_dalton
101438
uniprot
proteins
protein_family
SNF2/RAD54 helicase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
900
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q86WJ1}. Chromosome {ECO:0000250|UniProtKB:Q86WJ1}. Note=Localizes at sites of DNA damage; recruited by histones H2B and H3 poly-ADP-ribosylated on 'Ser-6' and 'Ser-10', respectively (H2BS6ADPr and H3S10ADPr) by PARP1 or PARP2. {ECO:0000250|UniProtKB:Q86WJ1}.
uniprot
proteins