ABHD18
entrez
80167
canonical
uniprot
Q0P651
canonical
ensembl
ENSG00000164074
resolver
ensp
ENSP00000397229
resolver
ensp
ENSP00000496010
resolver
ensp
ENSP00000540298
resolver
ensp
ENSP00000540299
resolver
ensp
ENSP00000627391
resolver
ensp
ENSP00000779708
resolver
genesymbol
ABHD18
resolver
genesymbol_syn
C4orf29
resolver
hgnc
HGNC:26111
resolver
uniprot
A0A2R8YEZ0
resolver
uniprot
A1A4W8
resolver
uniprot
A1A4W9
resolver
uniprot
Q9H7A7
resolver
uniprot_entry
ABD18_HUMAN
resolver
uniprot_sec
A0A2R8YEZ0
resolver
uniprot_sec
A1A4W8
resolver
uniprot_sec
A1A4W9
resolver
uniprot_sec
Q9H7A7
resolver
amino_acid_sequence
MGVSKLDILYRRLLLTKLFIRGWGRPEDLKRLFEFRKMIGNRERCQNLVSSDYPVHIDKIEEQSDCKILDGHFVSPMAHYVPDIMPIESVIARFQFIVPKEWNSKYRPVCIHLAGTGDHHYWRRRTLMARPMIKEARMASLLLENPYYGCRKPKDQVRSSLKNVSDLFVMGGALVLESAALLHWLEREGYGPLGMTGISMGGHMASLAVSNWPKPMPLIPCLSWSTASGVFTTGVLSKSINWRELEKQYYTQTVYEEEIIHMLEYCGTDSFKMGQEFVKHFTSSADKLTNLNLVSRTLNLDISNQVVSQKPADCHNSSKTSVSATSEGLLLQDTSKMKRFNQTLSTNKSGYTSRNPQSYHLLSKEQSRNSLRKESLIFMKGVMDECTHVANFSVPVDPSLIIVVQAKEDAYIPRTGVRSLQEIWPGCEIRYLEGGHISAYLFKQGLFRQAIYDAFDRFLHKYAN
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of an acyl chain from the tetra-acylated cardiolipin (CL) and produces the tri-acylated monolysocardiolipin (MLCL) (PubMed:40903572). Prefers CL with shorter and saturated fatty acyl chains as substrates (PubMed:40903572). Together with Tafazzin (TAZ), it participates in the mechanism of CL remodeling, a process consisting of repetitive cycles of hydrolysis and reacylation of the fatty acids that make up CL, where the nascent acyl chains are replaced with longer, unsaturated chains (PubMed:40903572). {ECO:0000269|PubMed:40903572}.
uniprot
proteins
mass_dalton
53044
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
34800366
uniprot
proteins
pubmed
40903572
uniprot
proteins
sequence_length
464
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:34800366, ECO:0000269|PubMed:40903572}.
uniprot
proteins