TEX264
entrez
51368
canonical
uniprot
Q9Y6I9
canonical
ensembl
ENSG00000164081
resolver
ensp
ENSP00000340969
resolver
ensp
ENSP00000378497
resolver
ensp
ENSP00000396628
resolver
ensp
ENSP00000398802
resolver
ensp
ENSP00000408186
resolver
ensp
ENSP00000477946
resolver
ensp
ENSP00000478139
resolver
ensp
ENSP00000529202
resolver
ensp
ENSP00000529204
resolver
ensp
ENSP00000529205
resolver
ensp
ENSP00000529206
resolver
ensp
ENSP00000529207
resolver
ensp
ENSP00000529208
resolver
ensp
ENSP00000529209
resolver
ensp
ENSP00000529210
resolver
ensp
ENSP00000529211
resolver
ensp
ENSP00000529212
resolver
ensp
ENSP00000529213
resolver
ensp
ENSP00000529214
resolver
ensp
ENSP00000529215
resolver
ensp
ENSP00000529216
resolver
ensp
ENSP00000529217
resolver
ensp
ENSP00000529218
resolver
ensp
ENSP00000529219
resolver
ensp
ENSP00000529220
resolver
ensp
ENSP00000529221
resolver
ensp
ENSP00000529222
resolver
ensp
ENSP00000529223
resolver
ensp
ENSP00000529225
resolver
ensp
ENSP00000529226
resolver
ensp
ENSP00000529227
resolver
ensp
ENSP00000529228
resolver
ensp
ENSP00000529229
resolver
ensp
ENSP00000529230
resolver
ensp
ENSP00000529231
resolver
ensp
ENSP00000529232
resolver
ensp
ENSP00000529233
resolver
ensp
ENSP00000529234
resolver
ensp
ENSP00000603360
resolver
ensp
ENSP00000603361
resolver
ensp
ENSP00000603362
resolver
ensp
ENSP00000603363
resolver
ensp
ENSP00000603364
resolver
ensp
ENSP00000611744
resolver
ensp
ENSP00000611745
resolver
ensp
ENSP00000611749
resolver
enst
ENST00000341333
resolver
enst
ENST00000395057
resolver
enst
ENST00000415259
resolver
enst
ENST00000416589
resolver
enst
ENST00000457573
resolver
enst
ENST00000611400
resolver
enst
ENST00000614067
resolver
enst
ENST00000859143
resolver
enst
ENST00000859145
resolver
enst
ENST00000859146
resolver
enst
ENST00000859147
resolver
enst
ENST00000859148
resolver
enst
ENST00000859149
resolver
enst
ENST00000859150
resolver
enst
ENST00000859151
resolver
enst
ENST00000859152
resolver
enst
ENST00000859153
resolver
enst
ENST00000859154
resolver
enst
ENST00000859155
resolver
enst
ENST00000859156
resolver
enst
ENST00000859157
resolver
enst
ENST00000859158
resolver
enst
ENST00000859159
resolver
enst
ENST00000859160
resolver
enst
ENST00000859161
resolver
enst
ENST00000859162
resolver
enst
ENST00000859163
resolver
enst
ENST00000859164
resolver
enst
ENST00000859166
resolver
enst
ENST00000859167
resolver
enst
ENST00000859168
resolver
enst
ENST00000859169
resolver
enst
ENST00000859170
resolver
enst
ENST00000859171
resolver
enst
ENST00000859172
resolver
enst
ENST00000859173
resolver
enst
ENST00000859174
resolver
enst
ENST00000859175
resolver
enst
ENST00000933301
resolver
enst
ENST00000933302
resolver
enst
ENST00000933303
resolver
enst
ENST00000933304
resolver
enst
ENST00000933305
resolver
enst
ENST00000941685
resolver
enst
ENST00000941686
resolver
enst
ENST00000941690
resolver
genesymbol
TEX264
resolver
genesymbol_syn
ZSIG11
resolver
hgnc
HGNC:30247
resolver
uniprot
A0A087WTU3
resolver
uniprot
B3KN87
resolver
uniprot
Q9UKD7
resolver
uniprot_entry
A0A087WTU3_HUMAN
resolver
uniprot_entry
TX264_HUMAN
resolver
uniprot_sec
B3KN87
resolver
uniprot_sec
Q9UKD7
resolver
amino_acid_sequence
MSDLLLLGLIGGLTLLLLLTLLAFAGYSGLLAGVEVSAGSPPIRNVTVAYKFHMGLYGETGRLFTESCSISPKLRSIAVYYDNPHMVPPDKCRCAVGSILSEGEESPSPELIDLYQKFGFKVFSFPAPSHVVTATFPYTTILSIWLATRRVHPALDTYIKERKLCAYPRLEIYQEDQIHFMCPLARQGDFYVPEMKETEWKWRGLVEAIDTQVDGTGADTMSDTSSVSLEVSPGSRETSAATLSPGASSRGWDDGDTRSEHSYSESGASGSSFEELDLEGEGPLGESRLDPGTEPLGTTKWLWEPTAPEKGKE
uniprot
proteins
function
FUNCTION: Major reticulophagy (also called ER-phagy) receptor that acts independently of other candidate reticulophagy receptors to remodel subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006537, PubMed:31006538). The ATG8-containing isolation membrane (IM) cradles a tubular segment of TEX264-positive ER near a three-way junction, allowing the formation of a synapse of 2 juxtaposed membranes with trans interaction between the TEX264 and ATG8 proteins (PubMed:31006537). Expansion of the IM would extend the capture of ER, possibly through a 'zipper-like' process involving continued trans TEX264-ATG8 interactions, until poorly understood mechanisms lead to the fission of relevant membranes and, ultimately, autophagosomal membrane closure (PubMed:31006537). Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: acts by bridging VCP/p97 to covalent DNA-protein cross-links (DPCs) and initiating resolution of DPCs by SPRTN (PubMed:32152270). {ECO:0000269|PubMed:31006537, ECO:0000269|PubMed:31006538, ECO:0000269|PubMed:32152270}.
uniprot
proteins
mass_dalton
34189
uniprot
proteins
mutagenesis
MUTAGEN 273; /note="F->A: Completely abolishes the interaction with LC3B."; /evidence="ECO:0000269|PubMed:31006537, ECO:0000269|PubMed:31006538"; MUTAGEN 276; /note="L->A: Completely abolishes the interaction with LC3B."; /evidence="ECO:0000269|PubMed:31006538
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
31006537
uniprot
proteins
pubmed
31006538
uniprot
proteins
pubmed
32152270
uniprot
proteins
sequence_length
313
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:31006537, ECO:0000269|PubMed:31006538}; Single-pass type III membrane protein {ECO:0000269|PubMed:31006537, ECO:0000269|PubMed:31006538}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:31006537, ECO:0000269|PubMed:31006538}. Cytoplasm, cytosol {ECO:0000269|PubMed:32152270}. Nucleus {ECO:0000269|PubMed:32152270}. Chromosome {ECO:0000269|PubMed:32152270}. Note=Is trafficked from tubular ER to growing autophagosomes via its cytosolic LIR motif (PubMed:31006537). Also found in the cytosol, nucleus and chromatin (PubMed:32152270). In response to formation of covalent DNA-protein cross-links (DPCs), localizes to the nuclear periphery, and associates with DNA replication forks (PubMed:32152270). {ECO:0000269|PubMed:31006537, ECO:0000269|PubMed:32152270}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..31; /note="Helical; Signal-anchor for type III membrane protein"; /evidence="ECO:0000255
uniprot
proteins