Ppp1r13l
entrez
333654
canonical
uniprot
Q5I1X5
canonical
ensembl
ENSMUSG00000040734
resolver
ensp
ENSMUSP00000047839
resolver
ensp
ENSMUSP00000250072
resolver
ensp
ENSMUSP00000250073
resolver
enst
ENSMUST00000047621
resolver
genesymbol
Ppp1r13l
resolver
genesymbol_syn
Nkip1
resolver
uniprot
Q3TCU2
resolver
uniprot_entry
IASPP_MOUSE
resolver
uniprot_entry
Q3TCU2_MOUSE
resolver
amino_acid_sequence
MDSEAFQHARDLLDLNFQSLAMKHMDLKQMELDTAAAKVDELTKQLESLWSDSPAPPGAQAGVPSRMARYSTSPVPEHFGSRGSPQKIATDGIEARFGRSESAPSLHPYSPLSPKGRPSSPRTPIYLQPDTYSSLDRAPSPRPRAFDGAGSPHGRAPSPRPGIGPVRQPGPSTPFDYLGRAGSPRGSPLAEGPQAFFPERGPSPRPPAAAYDTAGTFGSPLLGAGGSAFTPPLRAQDDSTLRRRPPKAWNESDLDVAYEKKSSQTASYERLDVFTRPASPGLQLLPWRESSLDGLGASGKDHLTSATLPRNYKVSPLASDRRSDVGSYRRSLGSAGPSGTLPRSWQPVSRIPMPPSSPQPRSTPRQRPIPLSMIFKLQNAFWEHGAGRAVLPGSPIFSRAPPPKLPPQPPPQPQMQPQPQPQPQMQPQSQAQPQTPAPQQTWSPMNEGLLKSPAELEPEPELEVLLAPVEEAGDADEGTVTRPLSPTRLQPALPPEAQTVPELEEVARVLAEIPRPLKRRGSMEQSPAVALPPTHKKQYQQIINRLFHRHGGPGPGGPEPELSTITEGSEARAGPPAPAPPAPIPPPAPPQSSPPEQPQSMEMRSVLRKVGSPRKARRARLNPLVLLLDAALTGELDVVQQAVKEMNDPSQPNEEGITALHNAICGANYPIVDFLIAAGANVNSPDSHGWTPLHCAASCNDTAICTALVQHGAAIFATTLSDGATAIEKCDPYREGYADCATYLADVEQSMGLMHNGVVYALWDYSAEFGDELSFREGESVTVLRRDGPEETDWWWASLHGQEGYVPRNYFGLFPRVKSQRSKI
uniprot
proteins
disease_involvement
DISEASE: Note=A recessive 14-bp deletion, which gives rise to a truncated protein, is the cause of the waved 3 phenotype (wa3). Wa3 mice have open eyes at birth, a wavy coat, and abnormalities of the heart and skin. They develop focal cardiac necrosis at an early age which progresses to fatal dilated cardiomyopathy (PubMed:15661756). Higher expression of pro-inflammatory cytokines is observed in the heart of wa3 mice compared to controls (PubMed:28069640). {ECO:0000269|PubMed:15661756, ECO:0000269|PubMed:28069640}.
uniprot
proteins
function
FUNCTION: Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis (By similarity). Is involved in NF-kappa-B dependent negative regulation of inflammatory response (PubMed:28069640). {ECO:0000250|UniProtKB:Q8WUF5, ECO:0000269|PubMed:28069640}.
uniprot
proteins
mass_dalton
88976
uniprot
proteins
protein_family
IASPP family
uniprot
proteins
pubmed
15661756
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
28069640
uniprot
proteins
sequence_length
824
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8WUF5}. Nucleus {ECO:0000250|UniProtKB:Q8WUF5}. Note=Predominantly cytoplasmic but also nuclear. {ECO:0000250|UniProtKB:Q8WUF5}.
uniprot
proteins