COPE
entrez
11316
canonical
uniprot
O14579
canonical
ensembl
ENSG00000105669
resolver
ensp
ENSP00000262812
resolver
ensp
ENSP00000343134
resolver
ensp
ENSP00000345674
resolver
ensp
ENSP00000469035
resolver
ensp
ENSP00000541155
resolver
ensp
ENSP00000541163
resolver
enst
ENST00000600932
resolver
genesymbol
COPE
resolver
hgnc
HGNC:2234
resolver
uniprot
A6NE29
resolver
uniprot
A6NKA3
resolver
uniprot
M0QXB4
resolver
uniprot
O76097
resolver
uniprot
Q6IBB8
resolver
uniprot
Q9UGP6
resolver
uniprot_entry
COPE_HUMAN
resolver
uniprot_entry
M0QXB4_HUMAN
resolver
uniprot_sec
A6NE29
resolver
uniprot_sec
A6NKA3
resolver
uniprot_sec
O76097
resolver
uniprot_sec
Q6IBB8
resolver
uniprot_sec
Q9UGP6
resolver
amino_acid_sequence
MAPPAPGPASGGSGEVDELFDVKNAFYIGSYQQCINEAQRVKLSSPERDVERDVFLYRAYLAQRKFGVVLDEIKPSSAPELQAVRMFADYLAHESRRDSIVAELDREMSRSVDVTNTTFLLMAASIYLHDQNPDAALRALHQGDSLECTAMTVQILLKLDRLDLARKELKRMQDLDEDATLTQLATAWVSLATGGEKLQDAYYIFQEMADKCSPTLLLLNGQAACHMAQGRWEAAEGLLQEALDKDSGYPETLVNLIVLSQHLGKPPEVTNRYLSQLKDAHRSHPFIKEYQAKENDFDRLVLQYAPSA
uniprot
proteins
function
FUNCTION: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
34482
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKA.; PTM: Polyubiquitinated by RCHY1 in the presence of androgen, leading to proteasomal degradation. {ECO:0000269|PubMed:17721809}.
uniprot
proteins
protein_family
COPE family
uniprot
proteins
pubmed
10469566
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17721809
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
308
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasmic vesicle, COPI-coated vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it. {ECO:0000250}.
uniprot
proteins