Grhl1
entrez
195733
canonical
uniprot
Q921D9
canonical
ensembl
ENSMUSG00000020656
resolver
ensp
ENSMUSP00000020985
resolver
ensp
ENSMUSP00000082689
resolver
ensp
ENSMUSP00000289904
resolver
enst
ENSMUST00000020985
resolver
genesymbol
Grhl1
resolver
genesymbol_syn
Mgr
resolver
genesymbol_syn
Tcfcp2l2
resolver
uniprot
E9QMF0
resolver
uniprot
Q8K5C1
resolver
uniprot_entry
E9QMF0_MOUSE
resolver
uniprot_entry
GRHL1_MOUSE
resolver
uniprot_sec
Q8K5C1
resolver
amino_acid_sequence
MTQEYDNKRPVLVLQNEALYPQRRSYTSEDEAWKSFLENPLTAATKAMMSINGDEDSAAALGLLYDYYKVPRERRSSAVKPEGEHPEPEHSKRNSIPNVTEQPLISAGENRVQVLKNVPFNIVLPHSNQLGIDKRGHLTAPDTTVTVSIATMPTHSIKTEIQPHGFAVGIPPAVYHSEPTERVVVFDRSLSTDQFSSGTQPPNAQRRTPDSTFSETFKEGVQEVFFPSELSLRMPGMNSEDYVFDNVSGNNFEYTLEASKSLRQKQGDSTMTYLNKGQFYPVTLKEGSSNEGIHHPISKVRSVIMVVFAEDKSREDQLRHWKYWHSRQHTAKQRCIDIADYKESFNTISNIEEIAYNAISFTWDINDEAKVFISVNCLSTDFSSQKGVKGLPLNIQIDTYSYNNRSNKPVHRAYCQIKVFCDKGAERKIRDEERKQSKRKVSDVKVQLLPSHKRTDITVFKPFLDLDTQPVLFIPDVHFTNLQRGSHVLSLPSEELEGEGSVLKRGPFGTEDDFGVPPPAKLTRTEEPKRVLLYVRKESEEVFDALMLKTPSLKGLMEAISDKYDVPHDKIGKIFKKCKKGILVNMDDNIVKHYSNEDTFQLQIEEAGGSYKLTLTEI
uniprot
proteins
function
FUNCTION: Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' (PubMed:18288204, PubMed:21081122). Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier (PubMed:18288204, PubMed:24586629). There is no genetic interaction with GRHL3, nor functional cooperativity due to diverse target gene selectivity during epithelia development (PubMed:21081122). May play a role in regulating glucose homeostasis and insulin signaling. {ECO:0000269|PubMed:18288204, ECO:0000269|PubMed:21081122, ECO:0000269|PubMed:24586629, ECO:0000269|PubMed:36688410}.
uniprot
proteins
mass_dalton
70176
uniprot
proteins
post_translational_modification
PTM: Methylation at Arg-9 and Lys-116 may be involved in regulating transcriptional activation. {ECO:0000250|UniProtKB:Q9NZI5}.
uniprot
proteins
protein_family
Grainyhead subfamily
uniprot
proteins
protein_family
Grh/CP2 family
uniprot
proteins
pubmed
12175488
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18288204
uniprot
proteins
pubmed
21081122
uniprot
proteins
pubmed
24586629
uniprot
proteins
pubmed
36688410
uniprot
proteins
sequence_length
618
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18288204}.
uniprot
proteins