PDK1
entrez
5163
canonical
uniprot
Q15118
canonical
ensembl
ENSG00000152256
resolver
ensp
ENSP00000282077
resolver
ensp
ENSP00000376352
resolver
ensp
ENSP00000664406
resolver
ensp
ENSP00000680634
resolver
ensp
ENSP00000797421
resolver
genesymbol
PDK1
resolver
genesymbol_syn
PDHK1
resolver
hgnc
HGNC:8809
resolver
uniprot
B2R6T1
resolver
uniprot
B7Z207
resolver
uniprot
B7Z7N6
resolver
uniprot
B7Z937
resolver
uniprot
D3DPD8
resolver
uniprot
E9PD65
resolver
uniprot
Q308M4
resolver
uniprot_entry
B7Z207_HUMAN
resolver
uniprot_entry
B7Z7N6_HUMAN
resolver
uniprot_entry
PDK1_HUMAN
resolver
uniprot_sec
B2R6T1
resolver
uniprot_sec
B7Z937
resolver
uniprot_sec
D3DPD8
resolver
uniprot_sec
E9PD65
resolver
uniprot_sec
Q308M4
resolver
activity_regulation
ACTIVITY REGULATION: Activity is enhanced by binding to the pyruvate dehydrogenase subunit DLAT. Inhibited by AZD7545; this compound interferes with DLAT binding and thereby inhibits kinase activity. Inhibited by dichloroacetate and radicicol (PubMed:17683942). Activated under hypoxic conditions by phosphoglycerate kinase PGK1-mediated phosphorylation at Thr-338 (PubMed:26942675). {ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:26942675}.
uniprot
proteins
amino_acid_sequence
MRLARLLRGAALAGPGPGLRAAGFSRSFSSDSGSSPASERGVPGQVDFYARFSPSPLSMKQFLDFGSVNACEKTSFMFLRQELPVRLANIMKEISLLPDNLLRTPSVQLVQSWYIQSLQELLDFKDKSAEDAKAIYDFTDTVIRIRNRHNDVIPTMAQGVIEYKESFGVDPVTSQNVQYFLDRFYMSRISIRMLLNQHSLLFGGKGKGSPSHRKHIGSINPNCNVLEVIKDGYENARRLCDLYYINSPELELEELNAKSPGQPIQVVYVPSHLYHMVFELFKNAMRATMEHHANRGVYPPIQVHVTLGNEDLTVKMSDRGGGVPLRKIDRLFNYMYSTAPRPRVETSRAVPLAGFGYGLPISRLYAQYFQGDLKLYSLEGYGTDAVIYIKALSTDSIERLPVYNKAAWKHYNTNHEADDWCVPSREPKDMTTFRSA
uniprot
proteins
ec_number
2.7.11.2
uniprot
proteins
function
FUNCTION: Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2 (PubMed:7499431, PubMed:18541534, PubMed:22195962, PubMed:26942675, PubMed:17683942). This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate (PubMed:18541534, PubMed:22195962, PubMed:26942675). Plays an important role in cellular responses to hypoxia and is important for cell proliferation under hypoxia (PubMed:18541534, PubMed:22195962, PubMed:26942675). {ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:18541534, ECO:0000269|PubMed:22195962, ECO:0000269|PubMed:26942675, ECO:0000269|PubMed:7499431}.
uniprot
proteins
mass_dalton
49244
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by constitutively activated ABL1, FGFR1, FLT3 and JAK2 (in vitro), and this may also occur in cancer cells that express constitutively activated ABL1, FGFR1, FLT3 and JAK2. Phosphorylation at Tyr-243 and Tyr-244 strongly increases kinase activity, while phosphorylation at Tyr-136 has a lesser effect (PubMed:22195962). Phosphorylated under hypoxic conditions at Thr-338 by phosphoglycerate kinase PGK1 which has an activating effect (PubMed:26942675). {ECO:0000269|PubMed:22195962, ECO:0000269|PubMed:26942675}.
uniprot
proteins
protein_family
PDK/BCKDK protein kinase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17683942
uniprot
proteins
pubmed
18541534
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21763680
uniprot
proteins
pubmed
22195962
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26942675
uniprot
proteins
pubmed
27505672
uniprot
proteins
pubmed
7499431
uniprot
proteins
sequence_length
436
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:22195962}.
uniprot
proteins