MMP9
entrez
4318
canonical
uniprot
P14780
canonical
ensembl
ENSG00000100985
resolver
ensp
ENSP00000361405
resolver
enst
ENST00000372330
resolver
genesymbol
MMP9
resolver
genesymbol_syn
CLG4B
resolver
hgnc
HGNC:7176
resolver
uniprot
B2R7V9
resolver
uniprot
Q3LR70
resolver
uniprot
Q8N725
resolver
uniprot
Q9H4Z1
resolver
uniprot
Q9UCJ9
resolver
uniprot
Q9UCL1
resolver
uniprot
Q9UDK2
resolver
uniprot_entry
MMP9_HUMAN
resolver
uniprot_sec
B2R7V9
resolver
uniprot_sec
Q3LR70
resolver
uniprot_sec
Q8N725
resolver
uniprot_sec
Q9H4Z1
resolver
uniprot_sec
Q9UCJ9
resolver
uniprot_sec
Q9UCL1
resolver
uniprot_sec
Q9UDK2
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by histatin-3 1/24 (histatin-5). Inhibited by ECM1. {ECO:0000269|PubMed:11179305, ECO:0000269|PubMed:16512877}.
uniprot
proteins
amino_acid_sequence
MSLWQPLVLVLLVLGCCFAAPRQRQSTLVLFPGDLRTNLTDRQLAEEYLYRYGYTRVAEMRGESKSLGPALLLLQKQLSLPETGELDSATLKAMRTPRCGVPDLGRFQTFEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALWSAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGIQGDAHFDDDELWSLGKGVVVPTRFGNADGAACHFPFIFEGRSYSACTTDGRSDGLPWCSTTANYDTDDRFGFCPSERLYTQDGNADGKPCQFPFIFQGQSYSACTTDGRSDGYRWCATTANYDRDKLFGFCPTRADSTVMGGNSAGELCVFPFTFLGKEYSTCTSEGRGDGRLWCATTSNFDSDKKWGFCPDQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMYRFTEGPPLHKDDVNGIRHLYGPRPEPEPRPPTTTTPQPTAPPTVCPTGPPTVHPSERPTAGPTGPPSAGPTGPPTAGPSTATTVPLSPVDDACNVNIFDAIAEIGNQLYLFKDGKYWRFSEGRGSRPQGPFLIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYTGASVLGPRRLDKLGLGADVAQVTGALRSGRGKMLLFSGRRLWRFDVKAQMVDPRSASEVDRMFPGVPLDTHDVFQYREKAYFCQDRFYWRVSSRSELNQVDQVGYVTYDILQCPED
uniprot
proteins
disease_involvement
DISEASE: Intervertebral disc disease (IDD) [MIM:603932]: A common musculo-skeletal disorder caused by degeneration of intervertebral disks of the lumbar spine. It results in low-back pain and unilateral leg pain. {ECO:0000269|PubMed:18455130}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; DISEASE: Metaphyseal anadysplasia 2 (MANDP2) [MIM:613073]: A bone development disorder characterized by skeletal anomalies that resolve spontaneously with age. Clinical characteristics are evident from the first months of life and include slight shortness of stature and a mild varus deformity of the legs. Patients attain a normal stature in adolescence and show improvement or complete resolution of varus deformity of the legs and rhizomelic micromelia. {ECO:0000269|PubMed:19615667}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.4.24.35
uniprot
proteins
function
FUNCTION: Matrix metalloproteinase that plays an essential role in local proteolysis of the extracellular matrix and in leukocyte migration (PubMed:12879005, PubMed:1480034, PubMed:2551898). Could play a role in bone osteoclastic resorption (By similarity). Cleaves KiSS1 at a Gly-|-Leu bond (PubMed:12879005). Cleaves NINJ1 to generate the Secreted ninjurin-1 form (PubMed:32883094). Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments (PubMed:1480034). Degrades fibronectin but not laminin or Pz-peptide. {ECO:0000250|UniProtKB:P41245, ECO:0000269|PubMed:12879005, ECO:0000269|PubMed:1480034, ECO:0000269|PubMed:2551898, ECO:0000269|PubMed:32883094}.
uniprot
proteins
mass_dalton
78458
uniprot
proteins
mutagenesis
MUTAGEN 402; /note="E->Q: Loss of activity."; /evidence="ECO:0000269|PubMed:12051944
uniprot
proteins
post_translational_modification
PTM: Processing of the precursor yields different active forms of 64, 67 and 82 kDa. Sequentially processing by MMP3 yields the 82 kDa matrix metalloproteinase-9. {ECO:0000269|PubMed:1371271, ECO:0000269|PubMed:1400481}.; PTM: N- and O-glycosylated. {ECO:0000269|PubMed:1464361}.
uniprot
proteins
protein_family
Peptidase M10A family
uniprot
proteins
pubmed
10598806
uniprot
proteins
pubmed
10644727
uniprot
proteins
pubmed
11179305
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12051944
uniprot
proteins
pubmed
12077439
uniprot
proteins
pubmed
12126625
uniprot
proteins
pubmed
1281792
uniprot
proteins
pubmed
12879005
uniprot
proteins
pubmed
1371271
uniprot
proteins
pubmed
1400481
uniprot
proteins
pubmed
1464361
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
1480034
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1645657
uniprot
proteins
pubmed
16512877
uniprot
proteins
pubmed
1653055
uniprot
proteins
pubmed
1653238
uniprot
proteins
pubmed
18455130
uniprot
proteins
pubmed
1932376
uniprot
proteins
pubmed
19615667
uniprot
proteins
pubmed
19893577
uniprot
proteins
pubmed
20479083
uniprot
proteins
pubmed
20800577
uniprot
proteins
pubmed
2551898
uniprot
proteins
pubmed
29328525
uniprot
proteins
pubmed
32883094
uniprot
proteins
pubmed
34742300
uniprot
proteins
pubmed
7669817
uniprot
proteins
pubmed
7683678
uniprot
proteins
pubmed
8426746
uniprot
proteins
sequence_length
707
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:2551898}.
uniprot
proteins