CFAP263
entrez
29070
canonical
uniprot
Q9H0I3
canonical
ensembl
ENSG00000103021
resolver
ensp
ENSP00000219299
resolver
ensp
ENSP00000402588
resolver
genesymbol
CFAP263
resolver
genesymbol_syn
CCDC113
resolver
hgnc
HGNC:25002
resolver
uniprot
B2RAQ7
resolver
uniprot
B4DR20
resolver
uniprot
Q9NZX2
resolver
uniprot_entry
CF263_HUMAN
resolver
uniprot_sec
B2RAQ7
resolver
uniprot_sec
B4DR20
resolver
uniprot_sec
Q9NZX2
resolver
amino_acid_sequence
MTDDESESVLSDSHEGSELELPVIQLCGLVEELSYVNSALKTETEMFEKYYAKLEPRDQRPPRLSEIKISAADYAQFRGRRRSKSRTGMDRGVGLTADQKLELVQKEVADMKDDLRHTRANAERDLQHHEAIIEEAEIRWSEVSREVHEFEKDILKAISKKKGSILATQKVMKYIEDMNRRRDNMKEKLRLKNVSLKVQRKKMLLQLRQKEEVSEALHDVDFQQLKIENAQFLETIEARNQELTQLKLSSGNTLQVLNAYKSKLHKAMEIYLNLDKEILLRKELLEKIEKETLQVEEDRAKAEAVNKRLRKQLAEFRAPQVMTYVREKILNADLEKSIRMWERKVEIAEMSLKGHRKAWNRMKITNEQLQADYLAGK
uniprot
proteins
function
FUNCTION: Component of centriolar satellites contributing to primary cilium formation (PubMed:25074808). In complex with CFAP263, acts as a regulator of ciliary beating that connects radial spoke 3 (RS3) to the inner dynein arm (IDA) and the nexin-dynein regulatory complex (N-DRC). The complex is positioned parallel to N-DRC and forms a connection between the arch at the base of RS3, the IDA tail and N-DRC (By similarity). {ECO:0000250|UniProtKB:Q22KK0, ECO:0000269|PubMed:25074808}.
uniprot
proteins
mass_dalton
44220
uniprot
proteins
protein_family
CFAP263 family
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
25074808
uniprot
proteins
sequence_length
377
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000269|PubMed:25074808}. Cell projection, cilium {ECO:0000250|UniProtKB:Q22KK0}. Note=Colocalized with HAP1 at centriolar satellites. Centriolar satellite localization requires PCM1 (PubMed:25074808). Localizes at cilium but not at the ciliary tips (By similarity). {ECO:0000250|UniProtKB:Q22KK0, ECO:0000269|PubMed:25074808}.
uniprot
proteins