POLD2
entrez
5425
canonical
uniprot
P49005
canonical
ensembl
ENSG00000106628
resolver
ensp
ENSP00000386105
resolver
ensp
ENSP00000395231
resolver
ensp
ENSP00000406702
resolver
ensp
ENSP00000480186
resolver
ensp
ENSP00000514051
resolver
ensp
ENSP00000514052
resolver
ensp
ENSP00000514053
resolver
ensp
ENSP00000551358
resolver
ensp
ENSP00000551359
resolver
ensp
ENSP00000551363
resolver
ensp
ENSP00000551364
resolver
ensp
ENSP00000551375
resolver
ensp
ENSP00000551380
resolver
ensp
ENSP00000551381
resolver
ensp
ENSP00000551382
resolver
ensp
ENSP00000601743
resolver
ensp
ENSP00000601745
resolver
ensp
ENSP00000601746
resolver
ensp
ENSP00000634287
resolver
ensp
ENSP00000634288
resolver
ensp
ENSP00000634289
resolver
ensp
ENSP00000634290
resolver
ensp
ENSP00000634297
resolver
enst
ENST00000406581
resolver
enst
ENST00000418438
resolver
enst
ENST00000452185
resolver
enst
ENST00000610533
resolver
enst
ENST00000698945
resolver
enst
ENST00000698946
resolver
enst
ENST00000698947
resolver
enst
ENST00000881299
resolver
enst
ENST00000881300
resolver
enst
ENST00000881304
resolver
enst
ENST00000881305
resolver
enst
ENST00000881316
resolver
enst
ENST00000881321
resolver
enst
ENST00000881322
resolver
enst
ENST00000881323
resolver
enst
ENST00000931684
resolver
enst
ENST00000931686
resolver
enst
ENST00000931687
resolver
enst
ENST00000964228
resolver
enst
ENST00000964229
resolver
enst
ENST00000964230
resolver
enst
ENST00000964231
resolver
enst
ENST00000964238
resolver
genesymbol
POLD2
resolver
hgnc
HGNC:9176
resolver
uniprot
A0A087WWF6
resolver
uniprot
A4D2J4
resolver
uniprot
B2R5S4
resolver
uniprot_entry
A0A087WWF6_HUMAN
resolver
uniprot_entry
DPOD2_HUMAN
resolver
uniprot_sec
A4D2J4
resolver
uniprot_sec
B2R5S4
resolver
amino_acid_sequence
MFSEQAAQRAHTLLSPPSANNATFARVPVATYTNSSQPFRLGERSFSRQYAHIYATRLIQMRPFLENRAQQHWGSGVGVKKLCELQPEEKCCVVGTLFKAMPLQPSILREVSEEHNLLPQPPRSKYIHPDDELVLEDELQRIKLKGTIDVSKLVTGTVLAVFGSVRDDGKFLVEDYCFADLAPQKPAPPLDTDRFVLLVSGLGLGGGGGESLLGTQLLVDVVTGQLGDEGEQCSAAHVSRVILAGNLLSHSTQSRDSINKAKYLTKKTQAASVEAVKMLDEILLQLSASVPVDVMPGEFDPTNYTLPQQPLHPCMFPLATAYSTLQLVTNPYQATIDGVRFLGTSGQNVSDIFRYSSMEDHLEILEWTLRVRHISPTAPDTLGCYPFYKTDPFIFPECPHVYFCGNTPSFGSKIIRGPEDQTVLLVTVPDFSATQTACLVNLRSLACQPISFSGFGAEDDDLGGLGLGP
uniprot
proteins
function
FUNCTION: Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex (PubMed:17317665, PubMed:22801543, PubMed:24449906). As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair (PubMed:12403614, PubMed:16510448, PubMed:19074196, PubMed:20334433, PubMed:24035200). Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences in catalytic activity. Most notably, Pol-delta3 shows higher proofreading activity than Pol-delta4 (PubMed:19074196, PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro, Pol-delta3 may also be better suited to fulfill this task, exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap, while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa, DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation (PubMed:20227374). Under conditions of DNA replication stress, required for the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites performed by Pol-delta4, independently of DNA polymerase zeta (REV3L) or eta (POLH). Facilitates abasic site bypass by DNA polymerase delta by promoting extension from the nucleotide inserted opposite the lesion. Also involved in TLS as a component of the DNA polymerase zeta complex (PubMed:24449906). Along with POLD3, dramatically increases the efficiency and processivity of DNA synthesis of the DNA polymerase zeta complex compared to the minimal zeta complex, consisting of only REV3L and REV7 (PubMed:24449906). {ECO:0000269|PubMed:12403614, ECO:0000269|PubMed:16510448, ECO:0000269|PubMed:19074196, ECO:0000269|PubMed:20227374, ECO:0000269|PubMed:20334433, ECO:0000269|PubMed:24035200, ECO:0000269|PubMed:24310611, ECO:0000269|PubMed:24449906}.
uniprot
proteins
mass_dalton
51289
uniprot
proteins
mutagenesis
MUTAGEN 217; /note="L->W: Loss of POLD3-binding in a yeast two-hybrid assay."; /evidence="ECO:0000269|PubMed:18818516"; MUTAGEN 224; /note="G->W: Loss of POLD3-binding in a yeast two-hybrid assay."; /evidence="ECO:0000269|PubMed:18818516"; MUTAGEN 231; /note="E->W: Loss of POLD3-binding in a yeast two-hybrid assay."; /evidence="ECO:0000269|PubMed:18818516
uniprot
proteins
protein_family
DNA polymerase delta/II small subunit family
uniprot
proteins
pubmed
10978529
uniprot
proteins
pubmed
11328591
uniprot
proteins
pubmed
11593007
uniprot
proteins
pubmed
12403614
uniprot
proteins
pubmed
12522211
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15670210
uniprot
proteins
pubmed
16510448
uniprot
proteins
pubmed
17317665
uniprot
proteins
pubmed
18818516
uniprot
proteins
pubmed
19074196
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20227374
uniprot
proteins
pubmed
20334433
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22801543
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23913683
uniprot
proteins
pubmed
24035200
uniprot
proteins
pubmed
24310611
uniprot
proteins
pubmed
24449906
uniprot
proteins
pubmed
31449058
uniprot
proteins
pubmed
8530069
uniprot
proteins
sequence_length
469
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22801543}. Note=Recruited to DNA damage sites within 2 hours following UV irradiation. {ECO:0000269|PubMed:22801543}.
uniprot
proteins