SLC5A8
entrez
160728
canonical
uniprot
Q8N695
canonical
ensembl
ENSG00000256870
resolver
ensembl
ENSG00000262217
resolver
ensp
ENSP00000445340
resolver
ensp
ENSP00000461697
resolver
enst
ENST00000536262
resolver
enst
ENST00000572861
resolver
genesymbol
SLC5A8
resolver
genesymbol_syn
AIT
resolver
genesymbol_syn
SMCT
resolver
genesymbol_syn
SMCT1
resolver
hgnc
HGNC:19119
resolver
uniprot
Q2TB99
resolver
uniprot
Q7Z2H9
resolver
uniprot_entry
SC5A8_HUMAN
resolver
uniprot_sec
Q2TB99
resolver
uniprot_sec
Q7Z2H9
resolver
activity_regulation
ACTIVITY REGULATION: Increase of iodide influx inhibited by addition of perchlorate (NaClO(4)), a competitive inhibitor of iodide uptake catalyzed by sodium iodide symporter (NIS) (PubMed:12107270). Cotransport of monocarboxylates and nicotinate strongly inhibited by probenecid, nonsteroid anti-inflammatory drugs (ibuprofen, fenoprofen, ketprofen, naproxen) in a Na(+)-dependent manner or by prolonged exposure to external concentrations of monocarboxylates (PubMed:15090606, PubMed:16729224, PubMed:38650461). {ECO:0000269|PubMed:12107270, ECO:0000269|PubMed:15090606, ECO:0000269|PubMed:38650461}.
uniprot
proteins
amino_acid_sequence
MDTPRGIGTFVVWDYVVFAGMLVISAAIGIYYAFAGGGQQTSKDFLMGGRRMTAVPVALSLTASFMSAVTVLGTPSEVYRFGAIFSIFAFTYFFVVVISAEVFLPVFYKLGITSTYEYLELRFNKCVRLCGTVLFIVQTILYTGIVIYAPALALNQVTGFDLWGAVVATGVVCTFYCTLGGLKAVIWTDVFQVGIMVAGFASVIIQAVVMQGGISTILNDAYDGGRLNFWNFNPNPLQRHTFWTIIIGGTFTWTSIYGVNQSQVQRYISCKSRFQAKLSLYINLVGLWAILTCSVFCGLALYSRYHDCDPWTAKKVSAPDQLMPYLVLDILQDYPGLPGLFVACAYSGTLSTVSSSINALAAVTVEDLIKPYFRSLSERSLSWISQGMSVVYGALCIGMAALASLMGALLQAALSVFGMVGGPLMGLFALGILVPFANSIGALVGLMAGFAISLWVGIGAQIYPPLPERTLPLHLDIQGCNSTYNETNLMTTTEMPFTTSVFQIYNVQRTPLMDNWYSLSYLYFSTVGTLVTLLVGILVSLSTGGRKQNLDPRYILTKEDFLSNFDIFKKKKHVLSYKSHPVEDGGTDNPAFNHIELNSDQSGKSNGTRL
uniprot
proteins
function
FUNCTION: Acts as an electrogenic sodium (Na(+)) and chloride (Cl-)-dependent sodium-coupled solute transporter, including transport of monocarboxylates (short-chain fatty acids including L-lactate, D-lactate, pyruvate, acetate, propionate, valerate and butyrate), mocarboxylate drugs (nicotinate, benzoate, salicylate and 5-aminosalicylate) and ketone bodies (beta-D-hydroxybutyrate, acetoacetate and alpha-ketoisocaproate), with a Na(+):substrate stoichiometry of between 4:1 and 2:1 (PubMed:14966140, PubMed:15090606, PubMed:16729224, PubMed:16805814, PubMed:17178845, PubMed:17245649, PubMed:17526579, PubMed:20211600, PubMed:30604288). Catalyzes passive carrier mediated diffusion of iodide (PubMed:12107270). Mediates iodide transport from the thyrocyte into the colloid lumen through the apical membrane (PubMed:12107270). May be responsible for the absorption of D-lactate and monocarboxylate drugs from the intestinal tract (PubMed:17245649). Acts as a tumor suppressor, suppressing colony formation in colon cancer, prostate cancer and glioma cell lines (PubMed:12829793, PubMed:15867356, PubMed:18037591). May play a critical role in the entry of L-lactate and ketone bodies into neurons by a process driven by an electrochemical Na(+) gradient and hence contribute to the maintenance of the energy status and function of neurons (PubMed:16805814). Mediates sodium-coupled electrogenic transport of pyroglutamate (5-oxo-L-proline) (PubMed:20211600). Can mediate the transport of chloride, bromide, iodide and nitrate ions when the external concentration of sodium ions is reduced (PubMed:19864324). Part of D-serine transport systems. May contribute to D-serine reabsorption at the brush border of renal proximal tubules thus modulating the dynamics of urinary versus blood D-serine levels. {ECO:0000269|PubMed:12107270, ECO:0000269|PubMed:12829793, ECO:0000269|PubMed:14966140, ECO:0000269|PubMed:15090606, ECO:0000269|PubMed:15867356, ECO:0000269|PubMed:16729224, ECO:0000269|PubMed:16805814, ECO:0000269|PubMed:17178845, ECO:0000269|PubMed:17245649, ECO:0000269|PubMed:17526579, ECO:0000269|PubMed:18037591, ECO:0000269|PubMed:19864324, ECO:0000269|PubMed:20211600, ECO:0000269|PubMed:30604288, ECO:0000269|PubMed:38650461}.
uniprot
proteins
mass_dalton
66578
uniprot
proteins
mutagenesis
MUTAGEN 608; /note="T->A: Loss of interaction with PDZK1."; /evidence="ECO:0000269|PubMed:30604288"; MUTAGEN 610; /note="L->A: Loss of interaction with PDZK1."; /evidence="ECO:0000269|PubMed:30604288
uniprot
proteins
protein_family
Sodium:solute symporter (SSF) (TC 2.A.21) family
uniprot
proteins
pubmed
12107270
uniprot
proteins
pubmed
12829793
uniprot
proteins
pubmed
14966140
uniprot
proteins
pubmed
15001644
uniprot
proteins
pubmed
15090606
uniprot
proteins
pubmed
15361710
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15867356
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
16729224
uniprot
proteins
pubmed
16805814
uniprot
proteins
pubmed
17178845
uniprot
proteins
pubmed
17245649
uniprot
proteins
pubmed
17526579
uniprot
proteins
pubmed
18037591
uniprot
proteins
pubmed
19864324
uniprot
proteins
pubmed
20211600
uniprot
proteins
pubmed
30604288
uniprot
proteins
pubmed
38650461
uniprot
proteins
sequence_length
610
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:12107270, ECO:0000269|PubMed:15001644, ECO:0000269|PubMed:17245649}; Multi-pass membrane protein {ECO:0000255}. Note=Expressed at the apical membrane of tall thyrocytes, colonic epithelial cells and proximal tubule epithelial cells. {ECO:0000269|PubMed:12107270, ECO:0000269|PubMed:15001644, ECO:0000269|PubMed:17245649}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..30; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 52..72; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 84..104; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 133..153; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 162..182; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 190..210; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 240..260; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 280..300; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 337..359; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 390..410; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 416..436; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 440..460; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 519..539; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins