Ghr
entrez
25235
canonical
uniprot
P16310
canonical
ensembl
ENSRNOG00000015654
resolver
ensembl
ENSRNOG00055006301
resolver
ensembl
ENSRNOG00060014684
resolver
ensembl
ENSRNOG00065021537
resolver
ensp
ENSRNOP00000044119
resolver
genesymbol
Ghr
resolver
uniprot
Q5RJL5
resolver
uniprot
Q64236
resolver
uniprot
Q80XW9
resolver
uniprot_entry
GHR_RAT
resolver
uniprot_entry
Q5RJL5_RAT
resolver
uniprot_sec
Q64236
resolver
uniprot_sec
Q80XW9
resolver
amino_acid_sequence
MDLWRVFLTLALAVSSDMFPGSGATPATLGKASPVLQRINPSLRESSSGKPRFTKCRSPELETFSCYWTEGDDHNLKVPGSIQLYYARRIAHEWTPEWKECPDYVSAGANSCYFNSSYTSIWIPYCIKLTTNGDLLDEKCFTVDEIVQPDPPIGLNWTLLNISLPGIRGDIQVSWQPPPSADVLKGWIILEYEIQYKEVNETKWKTMSPIWSTSVPLYSLRLDKEHEVRVRSRQRSFEKYSEFSEVLRVTFPQMDTLAACEEDFRFPWFLIIIFGIFGVAVMLFVVIFSKQQRIKMLILPPVPVPKIKGIDPDLLKEGKLEEVNTILGIHDNYKPDFYNDDSWVEFIELDIDDADEKTEESDTDRLLSDDQEKSAGILGAKDDDSGRTSCYDPDILDTDFHTSDMCDGTSEFAQPQKLKAEADLLCLDQKNLKNSPYDASLGSLHPSITLTMEDKPQPLLGSETESTHQLPSTPMSSPVSLANIDFYAQVSDITPAGGVVLSPGQKIKAGLAQGNTQLEVAAPCQENYSMNSAYFCESDAKKCIAAAPHMEATTCVKPSFNQEDIYITTESLTTTARMSETADTAPDAEPVPDYTTVHTVKSPRGLILNATALPLPDKKKFLSSCGYVSTDQLNKIMQ
uniprot
proteins
function
FUNCTION: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth (PubMed:11244571). On ligand binding, couples to, and activates the JAK2/STAT5 pathway (PubMed:11244571, PubMed:9231797). {ECO:0000269|PubMed:11244571, ECO:0000269|PubMed:9231797}.; FUNCTION: Receptor for pituitary gland growth hormone (GH1) involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. {ECO:0000250|UniProtKB:P10912}.; FUNCTION: [Growth hormone-binding protein]: The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. {ECO:0000250|UniProtKB:P10912}.
uniprot
proteins
mass_dalton
71237
uniprot
proteins
mutagenesis
MUTAGEN 346; /note="F->A: No internalization nor down-regulation. No effect on transcriptional signaling."; /evidence="ECO:0000269|PubMed:7615519
uniprot
proteins
post_translational_modification
PTM: The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE (By similarity). Shedding is inhibited by growth hormone (GH) binding to the receptor probably due to a conformational change in GHR rendering the receptor inaccessible to ADAM17 (By similarity). {ECO:0000250|UniProtKB:P10912, ECO:0000250|UniProtKB:P19941}.; PTM: On GH binding, phosphorylated on tyrosine residues in the cytoplasmic domain by JAK2 (PubMed:7545168, PubMed:9231797). Phosphorylation on either (or all of) Tyr-534, Tyr-566 and/or Tyr-627 is required for STAT5 activation. Phosphorylation on Tyr-333 would seem necessary for JAK2 activation (PubMed:7545168, PubMed:9231797). {ECO:0000269|PubMed:7545168, ECO:0000269|PubMed:9231797}.; PTM: Ubiquitinated by the ECS(SOCS2) complex following ligand-binding and phosphorylation by JAK2, leading to its degradation by the proteasome. Regulation by the ECS(SOCS2) complex acts as a negative feedback loop of growth hormone receptor signaling (By similarity). Ubiquitination is not sufficient for GHR internalization (By similarity). {ECO:0000250|UniProtKB:P10912, ECO:0000250|UniProtKB:P19941}.
uniprot
proteins
protein_family
Type 1 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
10585430
uniprot
proteins
pubmed
11244571
uniprot
proteins
pubmed
1446642
uniprot
proteins
pubmed
2722883
uniprot
proteins
pubmed
2792761
uniprot
proteins
pubmed
7545168
uniprot
proteins
pubmed
7615519
uniprot
proteins
pubmed
8063815
uniprot
proteins
pubmed
8921876
uniprot
proteins
pubmed
9231797
uniprot
proteins
sequence_length
638
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P10912}; Single-pass type I membrane protein {ECO:0000255}. Note=On growth hormone binding, GHR is ubiquitinated, internalized, down-regulated and transported into a degradative or non-degradative pathway. {ECO:0000250|UniProtKB:P19941}.; SUBCELLULAR LOCATION: [Growth hormone-binding protein]: Secreted {ECO:0000250|UniProtKB:P10912}. Note=Complexed to a substantial fraction of circulating GH. {ECO:0000250|UniProtKB:P10912}.
uniprot
proteins
transmembrane_region
TRANSMEM 266..289; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins