IZUMO1R
entrez
390243
canonical
uniprot
A6ND01
canonical
ensembl
ENSG00000183560
resolver
ensp
ENSP00000332963
resolver
ensp
ENSP00000510041
resolver
genesymbol
IZUMO1R
resolver
genesymbol_syn
FOLR4
resolver
genesymbol_syn
JUNO
resolver
hgnc
HGNC:32565
resolver
uniprot_entry
JUNO_HUMAN
resolver
amino_acid_sequence
MACWWPLLLELWTVMPTWAGDELLNICMNAKHHKRVPSPEDKLYEECIPWKDNACCTLTTSWEAHLDVSPLYNFSLFHCGLLMPGCRKHFIQAICFYECSPNLGPWIQPVGSLGWEVAPSGQGERVVNVPLCQEDCEEWWEDCRMSYTCKSNWRGGWDWSQGKNRCPKGAQCLPFSHYFPTPADLCEKTWSNSFKASPERRNSGRCLQKWFEPAQGNPNVAVARLFASSAPSWELSYTIMVCSLFLPFLS
uniprot
proteins
function
FUNCTION: Receptor for IZUMO1 present at the cell surface of oocytes (oolemma), which is essential for species-specific gamete recognition and fertilization. The IZUMO1:IZUMO1R/JUNO interaction is a necessary adhesion event between sperm and egg that is required for fertilization but is not sufficient for cell fusion (PubMed:30517645). The ligand-receptor interaction probably does not act as a membrane 'fusogen'. Does not bind folate. {ECO:0000250|UniProtKB:Q9EQF4, ECO:0000269|PubMed:30517645}.
uniprot
proteins
mass_dalton
28672
uniprot
proteins
mutagenesis
MUTAGEN 45; /note="E->A: Nearly abolishes interaction with IZUMO1."; /evidence="ECO:0000269|PubMed:27309818"; MUTAGEN 45; /note="E->K: Abolishes interaction with IZUMO1."; /evidence="ECO:0000269|PubMed:27309818"; MUTAGEN 62; /note="W->A: Nearly abolishes interaction with IZUMO1."; /evidence="ECO:0000269|PubMed:27309808, ECO:0000269|PubMed:27309818"; MUTAGEN 81; /note="L->A: Abolishes interaction with IZUMO1."; /evidence="ECO:0000269|PubMed:27309808, ECO:0000269|PubMed:27309818"; MUTAGEN 163; /note="K->E: Mildly decreases interaction with IZUMO1."; /evidence="ECO:0000269|PubMed:27309818
uniprot
proteins
post_translational_modification
PTM: The protein is rapidly cleaved following fertilization, being only weakly detectable in zona-intact fertilized eggs at telophase II and undetectable at the pronuclear stage. Sheding is probably required to block to polyspermy and ensuring egg fusion with a single sperm. {ECO:0000250|UniProtKB:Q9EQF4}.
uniprot
proteins
protein_family
Folate receptor family
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
24739963
uniprot
proteins
pubmed
27309808
uniprot
proteins
pubmed
27309818
uniprot
proteins
pubmed
30517645
uniprot
proteins
pubmed
36070373
uniprot
proteins
sequence_length
250
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:30517645}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q9EQF4}. Cell projection, microvillus membrane {ECO:0000269|PubMed:36070373}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q9EQF4}. Note=GPI-anchored at the oolemma microvilli. {ECO:0000250|UniProtKB:Q9EQF4}.
uniprot
proteins