Litaf
entrez
65161
canonical
uniprot
P0C0T0
canonical
ensembl
ENSRNOG00000002520
resolver
ensembl
ENSRNOG00055018573
resolver
ensembl
ENSRNOG00060012774
resolver
ensembl
ENSRNOG00065002811
resolver
ensp
ENSRNOP00000003412
resolver
ensp
ENSRNOP00055025534
resolver
ensp
ENSRNOP00060017181
resolver
ensp
ENSRNOP00065002721
resolver
enst
ENSRNOT00000003412
resolver
enst
ENSRNOT00055031602
resolver
enst
ENSRNOT00060021714
resolver
enst
ENSRNOT00065003862
resolver
genesymbol
Litaf
resolver
uniprot
B2RYP2
resolver
uniprot_entry
B2RYP2_RAT
resolver
uniprot_entry
LITAF_RAT
resolver
amino_acid_sequence
MSAPGPYQAAAGPSVMPTAPPTYEETVGVNSYYPTPPAPQPGPATGLITGPDGKGMNPPSYYTQPVPVPNANAIAVQTVYVQQPISFYDRPIQMCCPSCNKMIVTQLSYNAGALTWLSCGSLCLLGCVAGCCFIPFCVDALQDVDHYCPNCKALLGTYKRL
uniprot
proteins
function
FUNCTION: Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. Plays a role in targeting endocytosed EGFR and ERGG3 for lysosomal degradation, and thereby helps down-regulate downstream signaling cascades. Helps recruit the ESCRT complex components TSG101, HGS and STAM to cytoplasmic membranes. Probably plays a role in regulating protein degradation via its interaction with NEDD4. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role with STAT6 in the nucleus in regulating the expression of various cytokines. May regulate the expression of numerous cytokines, such as TNF, CCL2, CCL5, CXCL1, IL1A and IL10. {ECO:0000250|UniProtKB:Q99732}.
uniprot
proteins
mass_dalton
17030
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues in response to EGF. {ECO:0000250|UniProtKB:Q99732}.
uniprot
proteins
protein_family
CDIP1/LITAF family
uniprot
proteins
pubmed
9275072
uniprot
proteins
sequence_length
161
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q99732}. Nucleus {ECO:0000250|UniProtKB:Q99732}. Lysosome membrane {ECO:0000250|UniProtKB:Q99732}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q99732}; Cytoplasmic side {ECO:0000250|UniProtKB:Q99732}. Early endosome membrane {ECO:0000250|UniProtKB:Q99732}. Late endosome membrane {ECO:0000250|UniProtKB:Q99732}. Endosome membrane {ECO:0000250|UniProtKB:Q99732}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q99732}; Cytoplasmic side {ECO:0000250|UniProtKB:Q99732}. Cell membrane {ECO:0000250|UniProtKB:Q99732}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q99732}; Cytoplasmic side {ECO:0000250|UniProtKB:Q99732}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q99732}. Note=Associated with membranes of lysosomes, early and late endosomes. Can translocate from the cytoplasm into the nucleus (By similarity). Detected at Schmidt-Lanterman incisures and in nodal regions of myelinating Schwann cells (By similarity). {ECO:0000250|UniProtKB:Q99732, ECO:0000250|UniProtKB:Q9JLJ0}.
uniprot
proteins