Atp6v0a1
entrez
29757
canonical
uniprot
P25286
canonical
ensembl
ENSRNOG00000036814
resolver
ensp
ENSRNOP00000071954
resolver
ensp
ENSRNOP00000102690
resolver
ensp
ENSRNOP00000109984
resolver
enst
ENSRNOT00000087076
resolver
enst
ENSRNOT00000134551
resolver
enst
ENSRNOT00000138459
resolver
genesymbol
Atp6v0a1
resolver
genesymbol_syn
Atp6n1
resolver
genesymbol_syn
Vpp1
resolver
uniprot
A0A0G2K1R6
resolver
uniprot
A0ABK0LQM6
resolver
uniprot
A0ABK0M1I2
resolver
uniprot
D4ACY5
resolver
uniprot
Q2I6B2
resolver
uniprot
Q2I6B3
resolver
uniprot
Q2I6B4
resolver
uniprot
Q2I6B5
resolver
uniprot_entry
A0A0G2K1R6_RAT
resolver
uniprot_entry
A0ABK0LQM6_RAT
resolver
uniprot_entry
A0ABK0M1I2_RAT
resolver
uniprot_entry
Q2I6B2_RAT
resolver
uniprot_entry
Q2I6B3_RAT
resolver
uniprot_entry
Q2I6B4_RAT
resolver
uniprot_entry
Q2I6B5_RAT
resolver
uniprot_entry
VPP1_RAT
resolver
uniprot_sec
D4ACY5
resolver
amino_acid_sequence
MGELFRSEEMTLAQLFLQSEAAYCCVSELEELGKVQFRDLNPDVNVFQRKFVNEVRRCEEMDRKLRFVEKEIRKANIPIMDTGENPEVPFPRDMIDLEANFEKIENELKEINTNQEALKRNFLELTELKFILRKTQQFFDEMADPDLLEESSSLLEPNEMGRGAPLRLGFVAGVINRERIPTFERMLWRVCRGNVFLRQAEIENPLEDPVTGDYVHKSVFIIFFQGDQLKNRVKKICEGFRASLYPCPETPQERKEMASGVNTRIDDLQMVLNQTEDHRQRVLQAAAKNIRVWFIKVRKMKAIYHTLNLCNIDVTQKCLIAEVWCPVTDLDSIQFALRRGTEHSGSTVPSILNRMQTNQTPPTYNKTNKFTHGFQNIVDAYGIGTYREINPAPYTVITFPFLFAVMFGDFGHGILMTLFAVWMVLRESRILSQKNENEMFSMVFSGRYIILLMGLFSIYTGLIYNDCFSKSLNIFGSSWSVRPMFTIGNWTEETLLGSSVLQLNPAIPGVFGGPYPFGIDPIWNIATNKLTFLNSFKMKMSVILGIIHMLFGVSLSLFNHIYFKKPLNIYFGFIPEIIFMSSLFGYLVILIFYKWTAYDAHSSRNAPSLLIHFINMFLFSYPESGNAMLYSGQKGIQCFLIVVAMLCVPWMLLFKPLILRHQYLRKKHLGTLNFGGIRVGNGPTEEDAEIIQHDQLSTHSEDAEEPTEDEVFDFGDTMVHQAIHTIEYCLGCISNTASYLRLWALSLAHAQLSEVLWTMVIHIGLHVRSLAGGLGLFFIFAAFATLTVAILLIMEGLSAFLHALRLHWVEFQNKFYTGTGFKFLPFSFEHIREGKFDE
uniprot
proteins
function
FUNCTION: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:32165585). V-ATPase is responsible for the acidification of various organelles, such as lysosomes, endosomes, the trans-Golgi network, and secretory granules, including synaptic vesicles (PubMed:32165585). In certain cell types, can be exported to the plasma membrane, where it is involved in the acidification of the extracellular environment (PubMed:32165585). The V-ATPase complex also acts as an activator for mTORC1 on lysosomal membrane by promoting the guanine nucleotide exchange factor (GEF) of the Ragulator complex, thereby enabling mTORC1 recruitment (By similarity). Required for assembly and activity of the vacuolar ATPase (By similarity). Through its action on compartment acidification, plays an essential role in neuronal development in terms of integrity and connectivity of neurons (By similarity). {ECO:0000250|UniProtKB:P32563, ECO:0000250|UniProtKB:Q93050, ECO:0000250|UniProtKB:Q9Z1G4, ECO:0000269|PubMed:32165585}.
uniprot
proteins
mass_dalton
96328
uniprot
proteins
protein_family
V-ATPase 116 kDa subunit family
uniprot
proteins
pubmed
1704894
uniprot
proteins
pubmed
32165585
uniprot
proteins
sequence_length
838
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269|PubMed:32165585}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:32165585}; Multi-pass membrane protein {ECO:0000255}. Melanosome {ECO:0000250|UniProtKB:Q93050}.
uniprot
proteins
transmembrane_region
TRANSMEM 389..407; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 410..426; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 442..471; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 536..555; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 574..594; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 640..659; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 726..750; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 772..810; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins