IGFBP5
entrez
3488
canonical
uniprot
P24593
canonical
ensembl
ENSG00000115461
resolver
ensp
ENSP00000233813
resolver
enst
ENST00000233813
resolver
genesymbol
IGFBP5
resolver
genesymbol_syn
IBP5
resolver
hgnc
HGNC:5474
resolver
uniprot
Q5U0A3
resolver
uniprot_entry
IBP5_HUMAN
resolver
uniprot_sec
Q5U0A3
resolver
amino_acid_sequence
MVLLTAVLLLLAAYAGPAQSLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQVKIERDSREHEEPTTSEMAEETYSPKIFRPKHTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRIISAPEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHTFDSSNVE
uniprot
proteins
function
FUNCTION: Multifunctional protein that plays a critical role in regulating the availability of IGFs to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner (PubMed:18930415, PubMed:7683690). Increases the cell proliferation of osteoblasts, intestinal smooth muscle cells and neuroblastoma cells. Enhances adhesion and survival of epithelial cells but decreases adhesion of mesenchymal cells (By similarity). Once secreted, acts as a major mediator of mTORC1-dependent feedback inhibition of IGF1 signaling (By similarity). Also plays a role in the induction of extracellular matrix (ECM) production and deposition independently of its nuclear translocation and binding to IGFs (PubMed:20345844, PubMed:26103640). Acts itself as a growth factor that can act independently of IGFs to regulate bone formation. Acts as a ligand for the ROR1 receptor which triggers formation of ROR1/HER2 heterodimer to enhance CREB oncogenic signaling (PubMed:36949068). {ECO:0000250|UniProtKB:Q07079, ECO:0000269|PubMed:18930415, ECO:0000269|PubMed:20345844, ECO:0000269|PubMed:26103640, ECO:0000269|PubMed:36949068, ECO:0000269|PubMed:7683690}.
uniprot
proteins
mass_dalton
30570
uniprot
proteins
post_translational_modification
PTM: Cleaved by C1S in extracellular space. {ECO:0000269|PubMed:18930415}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1709938
uniprot
proteins
pubmed
1850257
uniprot
proteins
pubmed
1850258
uniprot
proteins
pubmed
18930415
uniprot
proteins
pubmed
20345844
uniprot
proteins
pubmed
22117064
uniprot
proteins
pubmed
26091039
uniprot
proteins
pubmed
26103640
uniprot
proteins
pubmed
36949068
uniprot
proteins
pubmed
7511611
uniprot
proteins
pubmed
7683690
uniprot
proteins
pubmed
9822601
uniprot
proteins
pubmed
9883900
uniprot
proteins
sequence_length
272
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:18930415, ECO:0000269|PubMed:20345844}. Cytoplasm {ECO:0000269|PubMed:20345844, ECO:0000269|PubMed:26103640}. Nucleus {ECO:0000269|PubMed:20345844, ECO:0000269|PubMed:26103640}.
uniprot
proteins