GTF2H2
entrez
2966
canonical
uniprot
Q13888
canonical
ensembl
ENSG00000145736
resolver
ensembl
ENSG00000275045
resolver
ensembl
ENSG00000276910
resolver
ensp
ENSP00000274400
resolver
ensp
ENSP00000328901
resolver
ensp
ENSP00000477954
resolver
ensp
ENSP00000479262
resolver
ensp
ENSP00000480548
resolver
ensp
ENSP00000486014
resolver
ensp
ENSP00000543650
resolver
ensp
ENSP00000543651
resolver
ensp
ENSP00000543652
resolver
ensp
ENSP00000586337
resolver
ensp
ENSP00000586338
resolver
ensp
ENSP00000586339
resolver
ensp
ENSP00000661731
resolver
ensp
ENSP00000661732
resolver
ensp
ENSP00000718735
resolver
ensp
ENSP00000718736
resolver
ensp
ENSP00000718738
resolver
ensp
ENSP00000773011
resolver
ensp
ENSP00000773016
resolver
ensp
ENSP00000773020
resolver
ensp
ENSP00000773024
resolver
ensp
ENSP00000773027
resolver
enst
ENST00000274400
resolver
enst
ENST00000330280
resolver
enst
ENST00000612581
resolver
enst
ENST00000617228
resolver
enst
ENST00000619997
resolver
enst
ENST00000628423
resolver
enst
ENST00000873591
resolver
enst
ENST00000873593
resolver
enst
ENST00000916279
resolver
enst
ENST00000916280
resolver
genesymbol
GTF2H2
resolver
genesymbol_syn
BTF2P44
resolver
hgnc
HGNC:4656
resolver
uniprot
Q15570
resolver
uniprot
Q15571
resolver
uniprot
Q9BS41
resolver
uniprot_entry
TF2H2_HUMAN
resolver
uniprot_sec
Q15570
resolver
uniprot_sec
Q15571
resolver
uniprot_sec
Q9BS41
resolver
amino_acid_sequence
MDEEPERTKRWEGGYERTWEILKEDESGSLKATIEDILFKAKRKRVFEHHGQVRLGMMRHLYVVVDGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNPISQIGIIVTKSKRAEKLTELSGNPRKHITSLKKAVDMTCHGEPSLYNSLSIAMQTLKHMPGHTSREVLIIFSSLTTCDPSNIYDLIKTLKAAKIRVSVIGLSAEVRVCTVLARETGGTYHVILDESHYKELLTHHVSPPPASSSSECSLIRMGFPQHTIASLSDQDAKPSFSMAHLDGNTEPGLTLGGYFCPQCRAKYCELPVECKICGLTLVSAPHLARSYHHLFPLDAFQEIPLEEYNGERFCYGCQGELKDQHVYVCAVCQNVFCVDCDVFVHDSLHCCPGCIHKIPAPSGV
uniprot
proteins
function
FUNCTION: Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. The N-terminus of GTF2H2 interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:11319235, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:8194529, ECO:0000269|PubMed:9852112}.
uniprot
proteins
mass_dalton
44419
uniprot
proteins
mutagenesis
MUTAGEN 291; /note="C->A: Reconstituted TFIIH complex lacks p62 and has no transcriptional activity."; /evidence="ECO:0000269|PubMed:11319235"; MUTAGEN 308; /note="C->A: Reconstituted TFIIH complex lacks p62 and has no transcriptional activity."; /evidence="ECO:0000269|PubMed:11319235"; MUTAGEN 345; /note="C->A: No effect on the transcriptional activity of the reconstituted TFIIH complex."; /evidence="ECO:0000269|PubMed:11319235"; MUTAGEN 360; /note="C->A: No effect on the transcriptional activity of the reconstituted TFIIH complex."; /evidence="ECO:0000269|PubMed:11319235"; MUTAGEN 363; /note="C->A: No effect on the transcriptional activity of the reconstituted TFIIH complex."; /evidence="ECO:0000269|PubMed:11319235"; MUTAGEN 376; /note="H->A: No effect on the transcriptional activity of the reconstituted TFIIH complex."; /evidence="ECO:0000269|PubMed:11319235"; MUTAGEN 380; /note="H->A: No effect on the transcriptional activity of the reconstituted TFIIH complex."; /evidence="ECO:0000269|PubMed:11319235"; MUTAGEN 382; /note="C->A: No effect on the transcriptional activity of the reconstituted TFIIH complex."; /evidence="ECO:0000269|PubMed:11319235
uniprot
proteins
protein_family
GTF2H2 family
uniprot
proteins
pubmed
10024882
uniprot
proteins
pubmed
11319235
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15843171
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
27193682
uniprot
proteins
pubmed
31253769
uniprot
proteins
pubmed
33902107
uniprot
proteins
pubmed
7552146
uniprot
proteins
pubmed
8194529
uniprot
proteins
pubmed
9063743
uniprot
proteins
pubmed
9503025
uniprot
proteins
pubmed
9852112
uniprot
proteins
sequence_length
395
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27193682}.
uniprot
proteins