Lap3
entrez
289668
canonical
uniprot
Q68FS4
canonical
ensembl
ENSRNOG00000003289
resolver
ensembl
ENSRNOG00055011436
resolver
ensembl
ENSRNOG00060015576
resolver
ensembl
ENSRNOG00065005340
resolver
ensp
ENSRNOP00000004770
resolver
genesymbol
Lap3
resolver
uniprot_entry
AMPL_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Bimane-S-cysteinylglycine-hydrolyzing activity is inhibited by o-phenanthroline or bestatin, and is activated by the addition of zinc chloride. {ECO:0000269|PubMed:12675513}.
uniprot
proteins
amino_acid_sequence
MYLLPLPAAARVALRRLGVRGLWDRGLSTADMTKGLVLGIYSKDKDDDVPQFTSAGENFNKLVSGRLREMLNISGPPLKAGKTRTFYGLHQDFPSVVVVGLGKRSAGVDDQENWHEGKENIRAAVAAGCRQVQDLELPSVEVDPCGDAQAAAEGAVLGLYEYDDLKQKKKVAVSAKLHGSGDLEAWEKGVLFASGQNLARQLMESPANEMTPTRFAEVIEKNLKSASSKTEVHIRTKSWIEEQEMGSFLSVAKGSEEPPVFLEIHYTGSPNATEAPLVFVGKGITFDSGGISIKASANMDLMRADMGGAATICSAIVSAAKLNLPINIIGLAPLCENMPSGKANKPGDVVRARNGKTIQVDNTDAEGRLILADALCYAHTFNPKVIINAATLTGAMDVALGSGATGVFTNSSWLWNKLFEASVETGDRVWRMPLFEHYTRQVIDCQLADVNNLGKYRSAGACTAAAFLREFVTHTKWAHLDIAGVMTNKDEIPYLRKGMSGRPTRTLIEFLLRFSKDSS
uniprot
proteins
ec_number
3.4.11.1
uniprot
proteins
ec_number
3.4.11.5
uniprot
proteins
ec_number
3.4.13.23
uniprot
proteins
function
FUNCTION: Cytosolic metallopeptidase that catalyzes the removal of unsubstituted N-terminal hydrophobic amino acids from various peptides (PubMed:12675513, PubMed:6108111). The presence of Zn(2+) ions is essential for the peptidase activity, and the association with other cofactors can modulate the substrate spectificity of the enzyme (By similarity). For instance, in the presence of Mn(2+), it displays a specific Cys-Gly hydrolyzing activity of Cys-Gly-S-conjugates (By similarity). Involved in the metabolism of glutathione and in the degradation of glutathione S-conjugates, which may play a role in the control of the cell redox status (PubMed:12675513). {ECO:0000250|UniProtKB:P00727, ECO:0000269|PubMed:12675513, ECO:0000269|PubMed:6108111}.
uniprot
proteins
mass_dalton
56150
uniprot
proteins
protein_family
Peptidase M17 family
uniprot
proteins
pubmed
12675513
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
6108111
uniprot
proteins
sequence_length
519
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12675513}.
uniprot
proteins