Cx3cl1
entrez
89808
canonical
uniprot
O55145
canonical
ensembl
ENSRNOG00000016326
resolver
ensp
ENSRNOP00000022128
resolver
genesymbol
Cx3cl1
resolver
genesymbol_syn
Acc1
resolver
genesymbol_syn
Fkn
resolver
genesymbol_syn
Scyd1
resolver
uniprot
A6JY48
resolver
uniprot
Q6IRF7
resolver
uniprot_entry
A6JY48_RAT
resolver
uniprot_entry
X3CL1_RAT
resolver
uniprot_sec
Q6IRF7
resolver
amino_acid_sequence
MAPSQLAWLLRLAAFFHLCTLLAGQHLGMTKCNITCHKMTSPIPVTLLIHYQLNQESCGKRAIILETRQHRHFCADPKEKWVQDAMKHLDHQTAALTRNGGKFEKRVDNVTPRITSATRGLSPTALAKPESATVEDLTLEPTAISQEARRPMGTSQEPPAAVTGSSPSTSKAQDAGLAAKPQSTGISEVAAVSTTIWPSSAVYQSGSSLWAEEKATESPPTIALSTQASTTSSPKQNVGSEGQPPWVQEQDSTPEKSPGPEETNPVHTDIFQDRGPGSTVHPSVAPTSSEKTPSPELVASGSQAPKVEEPIHATADPQKLSVFITPVPDSQAATRRQAVGLLAFLGLLFCLGVAMFAYQSLQGCPRKMAGEMVEGLRYVPRSCGSNSYVLVPV
uniprot
proteins
function
FUNCTION: Chemokine that acts as a ligand for both CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1. The CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis. Regulates leukocyte adhesion and migration processes at the endothelium. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1. {ECO:0000250|UniProtKB:P78423}.; FUNCTION: [Processed fractalkine]: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. {ECO:0000250|UniProtKB:P78423}.; FUNCTION: [Fractalkine]: The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. {ECO:0000250|UniProtKB:P78423}.
uniprot
proteins
mass_dalton
41977
uniprot
proteins
post_translational_modification
PTM: A soluble short form may be released by proteolytic cleavage from the long membrane-anchored form. {ECO:0000250|UniProtKB:P78423}.
uniprot
proteins
protein_family
Intercrine delta family
uniprot
proteins
pubmed
9724801
uniprot
proteins
pubmed
9845323
uniprot
proteins
sequence_length
393
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P78423}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Processed fractalkine]: Secreted {ECO:0000250|UniProtKB:P78423}.
uniprot
proteins
transmembrane_region
TRANSMEM 338..358; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins