INTS7
entrez
25896
canonical
uniprot
Q9NVH2
canonical
ensembl
ENSG00000143493
resolver
ensp
ENSP00000355959
resolver
ensp
ENSP00000355960
resolver
ensp
ENSP00000355961
resolver
ensp
ENSP00000388908
resolver
ensp
ENSP00000637577
resolver
genesymbol
INTS7
resolver
genesymbol_syn
C1orf73
resolver
hgnc
HGNC:24484
resolver
uniprot
B4DLZ6
resolver
uniprot
B7WNP6
resolver
uniprot
B7WPB6
resolver
uniprot
Q8N4K7
resolver
uniprot
Q8WUH5
resolver
uniprot
Q9H9V3
resolver
uniprot
Q9NVU5
resolver
uniprot
Q9UFC6
resolver
uniprot
Q9UFM3
resolver
uniprot_entry
INT7_HUMAN
resolver
uniprot_sec
B4DLZ6
resolver
uniprot_sec
B7WNP6
resolver
uniprot_sec
B7WPB6
resolver
uniprot_sec
Q8N4K7
resolver
uniprot_sec
Q8WUH5
resolver
uniprot_sec
Q9H9V3
resolver
uniprot_sec
Q9NVU5
resolver
uniprot_sec
Q9UFC6
resolver
uniprot_sec
Q9UFM3
resolver
amino_acid_sequence
MASNSTKSFLADAGYGEQELDANSALMELDKGLRSGKLGEQCEAVVRFPRLFQKYPFPILINSAFLKLADVFRVGNNFLRLCVLKVTQQSEKHLEKILNVDEFVKRIFSVIHSNDPVARAITLRMLGSLASIIPERKNAHHSIRQSLDSHDNVEVEAAVFAAANFSAQSKDFAVGICNKISEMIQGLATPVDLKLKLIPILQHMHHDAILASSARQLLQQLVTSYPSTKMVIVSLHTFTLLAASSLVDTPKQIQLLLQYLKNDPRKAVKRLAIQDLKLLANKTPHTWSRENIQALCECALQTPYDSLKLGMLSVLSTLSGTIAIKHYFSIVPGNVSSSPRSSDLVKLAQECCYHNNRGIAAHGVRVLTNITVSCQEKDLLALEQDAVFGLESLLVLCSQDDSPGAQATLKIALNCMVKLAKGRPHLSQSVVETLLTQLHSAQDAARILMCHCLAAIAMQLPVLGDGMLGDLMELYKVIGRSATDKQQELLVSLATVIFVASQKALSVESKAVIKQQLESVSNGWTVYRIARQASRMGNHDMAKELYQSLLTQVASEHFYFWLNSLKEFSHAEQCLTGLQEENYSSALSCIAESLKFYHKGIASLTAASTPLNPLSFQCEFVKLRIDLLQAFSQLICTCNSLKTSPPPAIATTIAMTLGNDLQRCGRISNQMKQSMEEFRSLASRYGDLYQASFDADSATLRNVELQQQSCLLISHAIEALILDPESASFQEYGSTGTAHADSEYERRMMSVYNHVLEEVESLNRKYTPVSYMHTACLCNAIIALLKVPLSFQRYFFQKLQSTSIKLALSPSPRNPAEPIAVQNNQQLALKVEGVVQHGSKPGLFRKIQSVCLNVSSTLQSKSGQDYKIPIDNMTNEMEQRVEPHNDYFSTQFLLNFAILGTHNITVESSVKDANGIVWKTGPRTTIFVKSLEDPYSQQIRLQQQQAQQPLQQQQQRNAYTRF
uniprot
proteins
function
FUNCTION: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes (PubMed:33243860, PubMed:38570683). The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA (PubMed:33243860, PubMed:38570683). The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs) (PubMed:16239144). May be not involved in the recruitment of cytoplasmic dynein to the nuclear envelope by different components of the INT complex (PubMed:23904267). Plays a role in DNA damage response (DDR) signaling during the S phase (PubMed:21659603). {ECO:0000269|PubMed:16239144, ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:23904267, ECO:0000269|PubMed:33243860, ECO:0000269|PubMed:38570683}.
uniprot
proteins
mass_dalton
106834
uniprot
proteins
protein_family
Integrator subunit 7 family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16239144
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21659603
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23904267
uniprot
proteins
pubmed
29471365
uniprot
proteins
pubmed
33243860
uniprot
proteins
pubmed
34762484
uniprot
proteins
pubmed
36869814
uniprot
proteins
pubmed
38570683
uniprot
proteins
pubmed
39032490
uniprot
proteins
sequence_length
962
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:29471365}. Chromosome {ECO:0000269|PubMed:21659603, ECO:0000269|PubMed:29471365, ECO:0000269|PubMed:39032490}. Cytoplasm {ECO:0000269|PubMed:23904267}. Note=Localizes to sites of DNA damage in a H2AX-independent manner. {ECO:0000269|PubMed:21659603}.
uniprot
proteins