Mdk
entrez
17242
canonical
uniprot
P12025
canonical
ensembl
ENSMUSG00000027239
resolver
ensp
ENSMUSP00000028672
resolver
ensp
ENSMUSP00000068413
resolver
ensp
ENSMUSP00000088090
resolver
ensp
ENSMUSP00000106941
resolver
ensp
ENSMUSP00000332102
resolver
enst
ENSMUST00000028672
resolver
enst
ENSMUST00000069423
resolver
enst
ENSMUST00000090602
resolver
enst
ENSMUST00000111309
resolver
genesymbol
Mdk
resolver
genesymbol_syn
Mk
resolver
uniprot
Q2LEK5
resolver
uniprot_entry
MK_MOUSE
resolver
uniprot_entry
Q2LEK5_MOUSE
resolver
amino_acid_sequence
MQHRGFFLLALLALLVVTSAVAKKKEKVKKGSECSEWTWGPCTPSSKDCGMGFREGTCGAQTQRVHCKVPCNWKKEFGADCKYKFESWGACDGSTGTKARQGTLKKARYNAQCQETIRVTKPCTSKTKSKTKAKKGKGKD
uniprot
proteins
function
FUNCTION: Secreted protein that functions as a cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (PubMed:16901907). Binds cell-surface proteoglycan receptors via their chondroitin sulfate (CS) groups (PubMed:17230638). Thereby regulates many processes like inflammatory response, cell proliferation, cell adhesion, cell growth, cell survival, tissue regeneration, cell differentiation and cell migration (PubMed:10683378, PubMed:15482347, PubMed:15509530, PubMed:17015789, PubMed:17230638, PubMed:19060126, PubMed:24458438, PubMed:25551381, PubMed:28183532, PubMed:29233575). Participates in inflammatory processes by exerting two different activities. Firstly, mediates neutrophils and macrophages recruitment to the sites of inflammation both by direct action by cooperating namely with ITGB2 via LRP1 and by inducing chemokine expression (PubMed:10683378, PubMed:15509530, PubMed:24458438, PubMed:28183532). This inflammation can be accompanied by epithelial cell survival and smooth muscle cell migration after renal and vessel damage, respectively (PubMed:10683378, PubMed:15509530). Secondly, suppresses the development of tolerogenic dendric cells thereby inhibiting the differentiation of regulatory T cells and also promote T cell expansion through NFAT signaling and Th1 cell differentiation (PubMed:28183532). Promotes tissue regeneration after injury or trauma. After heart damage negatively regulates the recruitment of inflammatory cells and mediates cell survival through activation of anti-apoptotic signaling pathways via MAPKs and AKT pathways through the activation of angiogenesis (PubMed:17015789, PubMed:19060126). Also facilitates liver regeneration as well as bone repair by recruiting macrophage at trauma site and by promoting cartilage development by facilitating chondrocyte differentiation (PubMed:15482347, PubMed:25551381). Plays a role in brain by promoting neural precursor cells survival and growth through interaction with heparan sulfate proteoglycans (PubMed:17230638). Binds PTPRZ1 and promotes neuronal migration and embryonic neurons survival (By similarity). Binds SDC3 or GPC2 and mediates neurite outgrowth and cell adhesion (By similarity). Binds chondroitin sulfate E and heparin leading to inhibition of neuronal cell adhesion induced by binding with GPC2 (PubMed:10978312). Binds CSPG5 and promotes elongation of oligodendroglial precursor-like cells (PubMed:16901907). Also binds ITGA6:ITGB1 complex; this interaction mediates MDK-induced neurite outgrowth (By similarity). Binds LRP1; promotes neuronal survival (By similarity). Binds ITGA4:ITGB1 complex; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation (By similarity). Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation (By similarity). Promotes epithelial to mesenchymal transition through interaction with NOTCH2 (By similarity). During arteriogenesis, plays a role in vascular endothelial cell proliferation by inducing VEGFA expression and release which in turn induces nitric oxide synthase expression. Moreover activates vasodilation through nitric oxide synthase activation (PubMed:29233575). Negatively regulates bone formation in response to mechanical load by inhibiting Wnt/beta-catenin signaling in osteoblasts (PubMed:20200993, PubMed:21185956). In addition plays a role in hippocampal development, working memory, auditory response, early fetal adrenal gland development and the female reproductive system (PubMed:10096022, PubMed:16619002, PubMed:17121547). {ECO:0000250|UniProtKB:P21741, ECO:0000269|PubMed:10096022, ECO:0000269|PubMed:10683378, ECO:0000269|PubMed:10978312, ECO:0000269|PubMed:15482347, ECO:0000269|PubMed:15509530, ECO:0000269|PubMed:16619002, ECO:0000269|PubMed:16901907, ECO:0000269|PubMed:17015789, ECO:0000269|PubMed:17121547, ECO:0000269|PubMed:17230638, ECO:0000269|PubMed:19060126, ECO:0000269|PubMed:20200993, ECO:0000269|PubMed:21185956, ECO:0000269|PubMed:24458438, ECO:0000269|PubMed:25551381, ECO:0000269|PubMed:28183532, ECO:0000269|PubMed:29233575}.
uniprot
proteins
mass_dalton
15434
uniprot
proteins
mutagenesis
MUTAGEN 100; /note="R->Q: Decreases affinity binding to PTPRZ1. Decreases affinity binding to PTPRZ1; when associated with Q-105 and Q-106. Decreases neuron migration. Decreases neuron migration; when associated with Q-105 and Q-106."; /evidence="ECO:0000269|PubMed:10212223"; MUTAGEN 105; /note="K->Q: Does not affect binding with PTPRZ1. Does not affect binding with PTPRZ1; when associated with Q-106. Does not affect positive regulation of neuron migration."; /evidence="ECO:0000269|PubMed:10212223"; MUTAGEN 106; /note="K->Q: Does not affect binding with PTPRZ1. Does not affect binding with PTPRZ1; when associated with Q-105. Does not affect positive regulation of neuron migration."; /evidence="ECO:0000269|PubMed:10212223
uniprot
proteins
protein_family
Pleiotrophin family
uniprot
proteins
pubmed
10096022
uniprot
proteins
pubmed
10212223
uniprot
proteins
pubmed
10683378
uniprot
proteins
pubmed
10978312
uniprot
proteins
pubmed
12084985
uniprot
proteins
pubmed
15482347
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15509530
uniprot
proteins
pubmed
16619002
uniprot
proteins
pubmed
16901907
uniprot
proteins
pubmed
17015789
uniprot
proteins
pubmed
17121547
uniprot
proteins
pubmed
17230638
uniprot
proteins
pubmed
19060126
uniprot
proteins
pubmed
20200993
uniprot
proteins
pubmed
21185956
uniprot
proteins
pubmed
22323540
uniprot
proteins
pubmed
2345177
uniprot
proteins
pubmed
2355021
uniprot
proteins
pubmed
24458438
uniprot
proteins
pubmed
25551381
uniprot
proteins
pubmed
28183532
uniprot
proteins
pubmed
29233575
uniprot
proteins
pubmed
3355557
uniprot
proteins
pubmed
8827451
uniprot
proteins
pubmed
9089390
uniprot
proteins
sequence_length
140
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
uniprot
proteins