TRIM15
entrez
89870
canonical
uniprot
Q9C019
canonical
ensembl
ENSG00000137384
resolver
ensembl
ENSG00000204610
resolver
ensembl
ENSG00000224145
resolver
ensembl
ENSG00000227147
resolver
ensembl
ENSG00000233599
resolver
ensembl
ENSG00000235259
resolver
ensembl
ENSG00000235905
resolver
ensembl
ENSG00000235960
resolver
ensp
ENSP00000365884
resolver
ensp
ENSP00000674555
resolver
genesymbol
TRIM15
resolver
genesymbol_syn
RNF93
resolver
genesymbol_syn
ZNF178
resolver
genesymbol_syn
ZNFB7
resolver
hgnc
HGNC:16284
resolver
uniprot
A2BEC9
resolver
uniprot
A6NEF7
resolver
uniprot
O95604
resolver
uniprot
Q5SRL0
resolver
uniprot
Q8IUX9
resolver
uniprot
Q9C018
resolver
uniprot_entry
Q5SRL0_HUMAN
resolver
uniprot_entry
TRI15_HUMAN
resolver
uniprot_sec
A2BEC9
resolver
uniprot_sec
A6NEF7
resolver
uniprot_sec
O95604
resolver
uniprot_sec
Q8IUX9
resolver
uniprot_sec
Q9C018
resolver
amino_acid_sequence
MPATPSLKVVHELPACTLCAGPLEDAVTIPCGHTFCRLCLPALSQMGAQSSGKILLCPLCQEEEQAETPMAPVPLGPLGETYCEEHGEKIYFFCENDAEFLCVFCREGPTHQAHTVGFLDEAIQPYRDRLRSRLEALSTERDEIEDVKCQEDQKLQVLLTQIESKKHQVETAFERLQQELEQQRCLLLARLRELEQQIWKERDEYITKVSEEVTRLGAQVKELEEKCQQPASELLQDVRVNQSRCEMKTFVSPEAISPDLVKKIRDFHRKILTLPEMMRMFSENLAHHLEIDSGVITLDPQTASRSLVLSEDRKSVRYTRQKKSLPDSPLRFDGLPAVLGFPGFSSGRHRWQVDLQLGDGGGCTVGVAGEGVRRKGEMGLSAEDGVWAVIISHQQCWASTSPGTDLPLSEIPRGVRVALDYEAGQVTLHNAQTQEPIFTFTASFSGKVFPFFAVWKKGSCLTLKG
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that plays a role in several processes including innate antiviral immnity, cell migration and chemotaxis (PubMed:23077300, PubMed:34142270). Acts as a 'Lys-63'-specific ubiquitin ligase for MAPK1/ERK2 and MAPK3/ERK1, promoting their activation by facilitating their interaction with MAP2K1 and MAP2K2 (PubMed:34497368). Also plays a role in cell migration and chemotaxis by acting as a stable focal adhesion component upon recruitment by multi-adapter protein paxillin/PXN (PubMed:25015296). Functions in the RIGI-mediated interferon induction pathway upstream or at the level of MAVS (PubMed:23077300). Inhibits NF-kappa-B activation by turnover of 'Lys-63'-linked ubiquitination of MAP3K7/TAK1. Mechanistically, prevents TRIM8 cytoplasmic translocation and thus inhibits TRIM8-mediated 'Lys-63'-linked polyubiquitination of MAP3K7/TAK1 in the cytoplasm (PubMed:34871740). Also plays an important regulatory effect on the activation of hepatic stellate cells (HSCs). {ECO:0000269|PubMed:23077300, ECO:0000269|PubMed:25015296, ECO:0000269|PubMed:34142270, ECO:0000269|PubMed:34497368, ECO:0000269|PubMed:34871740}.
uniprot
proteins
mass_dalton
52113
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
11331580
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23077300
uniprot
proteins
pubmed
25015296
uniprot
proteins
pubmed
34142270
uniprot
proteins
pubmed
34497368
uniprot
proteins
pubmed
34871740
uniprot
proteins
pubmed
40821731
uniprot
proteins
pubmed
8304341
uniprot
proteins
sequence_length
465
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:34142270, ECO:0000269|PubMed:34871740}. Nucleus {ECO:0000269|PubMed:34871740}. Cell junction, focal adhesion {ECO:0000269|PubMed:25015296}. Note=Localizes to focal adhesions during the early stage of adhesion biogenesis. {ECO:0000269|PubMed:25015296}.
uniprot
proteins