PRMT5
entrez
10419
canonical
uniprot
O14744
canonical
ensembl
ENSG00000100462
resolver
ensp
ENSP00000216350
resolver
ensp
ENSP00000319169
resolver
ensp
ENSP00000380582
resolver
ensp
ENSP00000380583
resolver
ensp
ENSP00000452555
resolver
genesymbol
PRMT5
resolver
genesymbol_syn
HRMT1L5
resolver
genesymbol_syn
IBP72
resolver
genesymbol_syn
JBP1
resolver
genesymbol_syn
SKB1
resolver
hgnc
HGNC:10894
resolver
uniprot
A8MTP3
resolver
uniprot
A8MZ91
resolver
uniprot
B4DV00
resolver
uniprot
B4DX49
resolver
uniprot
B4DY30
resolver
uniprot
B5BU10
resolver
uniprot
D3DS33
resolver
uniprot
E2QRE7
resolver
uniprot
Q6IBR1
resolver
uniprot
Q9UKH1
resolver
uniprot_entry
ANM5_HUMAN
resolver
uniprot_entry
B4DV00_HUMAN
resolver
uniprot_sec
A8MTP3
resolver
uniprot_sec
A8MZ91
resolver
uniprot_sec
B4DX49
resolver
uniprot_sec
B4DY30
resolver
uniprot_sec
B5BU10
resolver
uniprot_sec
D3DS33
resolver
uniprot_sec
E2QRE7
resolver
uniprot_sec
Q6IBR1
resolver
uniprot_sec
Q9UKH1
resolver
activity_regulation
ACTIVITY REGULATION: Activity is increased by EGF, HGF, FGF1 or FGF2 treatments, and slightly decreased by NGF treatment. {ECO:0000269|PubMed:21917714}.
uniprot
proteins
amino_acid_sequence
MAAMAVGGAGGSRVSSGRDLNCVPEIADTLGAVAKQGFDFLCMPVFHPRFKREFIQEPAKNRPGPQTRSDLLLSGRDWNTLIVGKLSPWIRPDSKVEKIRRNSEAAMLQELNFGAYLGLPAFLLPLNQEDNTNLARVLTNHIHTGHHSSMFWMRVPLVAPEDLRDDIIENAPTTHTEEYSGEEKTWMWWHNFRTLCDYSKRIAVALEIGADLPSNHVIDRWLGEPIKAAILPTSIFLTNKKGFPVLSKMHQRLIFRLLKLEVQFIITGTNHHSEKEFCSYLQYLEYLSQNRPPPNAYELFAKGYEDYLQSPLQPLMDNLESQTYEVFEKDPIKYSQYQQAIYKCLLDRVPEEEKDTNVQVLMVLGAGRGPLVNASLRAAKQADRRIKLYAVEKNPNAVVTLENWQFEEWGSQVTVVSSDMREWVAPEKADIIVSELLGSFADNELSPECLDGAQHFLKDDGVSIPGEYTSFLAPISSSKLYNEVRACREKDRDPEAQFEMPYVVRLHNFHQLSAPQPCFTFSHPNRDPMIDNNRYCTLEFPVEVNTVLHGFAGYFETVLYQDITLSIRPETHSPGMFSWFPILFPIKQPITVREGQTICVRFWRCSNSKKVWYEWAVTAPVCSAIHNPTGRSYTIGL
uniprot
proteins
ec_number
2.1.1.320
uniprot
proteins
function
FUNCTION: Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA (PubMed:10531356, PubMed:11152681, PubMed:11747828, PubMed:12411503, PubMed:15737618, PubMed:17709427, PubMed:20159986, PubMed:20810653, PubMed:21081503, PubMed:21258366, PubMed:21917714, PubMed:22269951, PubMed:33762328). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles (PubMed:11747828, PubMed:12411503, PubMed:17709427). Methylates SUPT5H and may regulate its transcriptional elongation properties (PubMed:12718890). May methylate the N-terminal region of MBD2 (PubMed:16428440). Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. Methylates histone H2A and H4 'Arg-3' during germ cell development (By similarity). Methylates histone H3 'Arg-8', which may repress transcription (By similarity). Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage (By similarity). Methylates RPS10 (PubMed:20159986). Attenuates EGF signaling through the MAPK1/MAPK3 pathway acting at 2 levels. First, monomethylates EGFR; this enhances EGFR 'Tyr-1197' phosphorylation and PTPN6 recruitment, eventually leading to reduced SOS1 phosphorylation (PubMed:21258366, PubMed:21917714). Second, methylates RAF1 and probably BRAF, hence destabilizing these 2 signaling proteins and reducing their catalytic activity (PubMed:21917714). Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. Methylates HOXA9 (PubMed:22269951). Methylates and regulates SRGAP2 which is involved in cell migration and differentiation (PubMed:20810653). Acts as a transcriptional corepressor in CRY1-mediated repression of the core circadian component PER1 by regulating the H4R3 dimethylation at the PER1 promoter (By similarity). Methylates GM130/GOLGA2, regulating Golgi ribbon formation (PubMed:20421892). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). Symmetrically methylates POLR2A, a modification that allows the recruitment to POLR2A of proteins including SMN1/SMN2 and SETX. This is required for resolving RNA-DNA hybrids created by RNA polymerase II, that form R-loop in transcription terminal regions, an important step in proper transcription termination (PubMed:26700805). Along with LYAR, binds the promoter of gamma-globin HBG1/HBG2 and represses its expression (PubMed:25092918). Symmetrically methylates NCL (PubMed:21081503). Methylates p53/TP53; methylation might possibly affect p53/TP53 target gene specificity (PubMed:19011621). Involved in spliceosome maturation and mRNA splicing in prophase I spermatocytes through the catalysis of the symmetrical arginine dimethylation of SNRPB (small nuclear ribonucleoprotein-associated protein) and the interaction with tudor domain-containing protein TDRD6 (By similarity). Acts as a negative regulator of cGAS-STING signaling by mediating methylation of CGAS, preventing DNA-binding ability of CGAS (PubMed:33762328). {ECO:0000250|UniProtKB:Q8CIG8, ECO:0000269|PubMed:10531356, ECO:0000269|PubMed:11152681, ECO:0000269|PubMed:11747828, ECO:0000269|PubMed:12411503, ECO:0000269|PubMed:12718890, ECO:0000269|PubMed:15737618, ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:17709427, ECO:0000269|PubMed:19011621, ECO:0000269|PubMed:20159986, ECO:0000269|PubMed:20421892, ECO:0000269|PubMed:20810653, ECO:0000269|PubMed:21081503, ECO:0000269|PubMed:21258366, ECO:0000269|PubMed:21917714, ECO:0000269|PubMed:22269951, ECO:0000269|PubMed:25092918, ECO:0000269|PubMed:25284789, ECO:0000269|PubMed:26700805, ECO:0000269|PubMed:33762328}.
uniprot
proteins
mass_dalton
72684
uniprot
proteins
mutagenesis
MUTAGEN 365..369; /note="Missing: Increased MAPK1/MAPK3 phosphorylation in response to EGF."; /evidence="ECO:0000269|PubMed:21917714"; MUTAGEN 367..368; /note="GR->AA: Abolishes enzymatic activity."; /evidence="ECO:0000269|PubMed:15485929"; MUTAGEN 444; /note="E->Q: Abolished arginine methyltransferase activity."; /evidence="ECO:0000269|PubMed:33762328
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
Protein arginine N-methyltransferase family
uniprot
proteins
pubmed
10531356
uniprot
proteins
pubmed
10734105
uniprot
proteins
pubmed
11152681
uniprot
proteins
pubmed
11747828
uniprot
proteins
pubmed
12101096
uniprot
proteins
pubmed
12411503
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
12718890
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15485929
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15737618
uniprot
proteins
pubmed
16087681
uniprot
proteins
pubmed
16428440
uniprot
proteins
pubmed
17184735
uniprot
proteins
pubmed
17709427
uniprot
proteins
pubmed
18404153
uniprot
proteins
pubmed
18984161
uniprot
proteins
pubmed
19011621
uniprot
proteins
pubmed
19054851
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20159986
uniprot
proteins
pubmed
20421892
uniprot
proteins
pubmed
20810653
uniprot
proteins
pubmed
21081503
uniprot
proteins
pubmed
21258366
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21917714
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22269951
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23071334
uniprot
proteins
pubmed
25092918
uniprot
proteins
pubmed
25284789
uniprot
proteins
pubmed
26700805
uniprot
proteins
pubmed
33376131
uniprot
proteins
pubmed
33762328
uniprot
proteins
pubmed
9556550
uniprot
proteins
pubmed
9843966
uniprot
proteins
sequence_length
637
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21081503, ECO:0000269|PubMed:21917714, ECO:0000269|PubMed:22269951}. Nucleus {ECO:0000269|PubMed:18404153, ECO:0000269|PubMed:21081503, ECO:0000269|PubMed:21917714, ECO:0000269|PubMed:22269951}. Chromosome {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:33376131}. Golgi apparatus {ECO:0000269|PubMed:20421892}. Note=Localizes to promoter regions of target genes on chromosomes (PubMed:33376131). Localizes to methylated chromatin (PubMed:16428440). {ECO:0000269|PubMed:16428440, ECO:0000269|PubMed:33376131}.
uniprot
proteins