CERS4
entrez
79603
canonical
uniprot
Q9HA82
canonical
ensembl
ENSG00000090661
resolver
ensp
ENSP00000251363
resolver
ensp
ENSP00000453509
resolver
ensp
ENSP00000556796
resolver
ensp
ENSP00000556797
resolver
ensp
ENSP00000556798
resolver
ensp
ENSP00000556799
resolver
ensp
ENSP00000556800
resolver
ensp
ENSP00000556801
resolver
ensp
ENSP00000556803
resolver
ensp
ENSP00000556804
resolver
ensp
ENSP00000556805
resolver
ensp
ENSP00000556806
resolver
ensp
ENSP00000556810
resolver
ensp
ENSP00000556811
resolver
ensp
ENSP00000556813
resolver
ensp
ENSP00000556814
resolver
ensp
ENSP00000556816
resolver
ensp
ENSP00000556818
resolver
ensp
ENSP00000556820
resolver
ensp
ENSP00000556822
resolver
ensp
ENSP00000556823
resolver
ensp
ENSP00000556824
resolver
ensp
ENSP00000556825
resolver
ensp
ENSP00000556826
resolver
ensp
ENSP00000556828
resolver
ensp
ENSP00000556832
resolver
ensp
ENSP00000556833
resolver
ensp
ENSP00000556834
resolver
ensp
ENSP00000556835
resolver
ensp
ENSP00000556836
resolver
ensp
ENSP00000556837
resolver
ensp
ENSP00000583098
resolver
ensp
ENSP00000583099
resolver
ensp
ENSP00000583100
resolver
ensp
ENSP00000583101
resolver
ensp
ENSP00000583102
resolver
ensp
ENSP00000583103
resolver
ensp
ENSP00000583104
resolver
ensp
ENSP00000583106
resolver
ensp
ENSP00000583107
resolver
ensp
ENSP00000583109
resolver
ensp
ENSP00000583111
resolver
ensp
ENSP00000583112
resolver
ensp
ENSP00000583114
resolver
ensp
ENSP00000583116
resolver
ensp
ENSP00000583117
resolver
ensp
ENSP00000583118
resolver
ensp
ENSP00000583120
resolver
ensp
ENSP00000583122
resolver
ensp
ENSP00000634480
resolver
ensp
ENSP00000634481
resolver
ensp
ENSP00000634484
resolver
ensp
ENSP00000634485
resolver
ensp
ENSP00000634487
resolver
ensp
ENSP00000634488
resolver
ensp
ENSP00000634489
resolver
ensp
ENSP00000634490
resolver
ensp
ENSP00000634491
resolver
ensp
ENSP00000634492
resolver
ensp
ENSP00000634493
resolver
ensp
ENSP00000634494
resolver
ensp
ENSP00000634495
resolver
ensp
ENSP00000655576
resolver
enst
ENST00000251363
resolver
enst
ENST00000559450
resolver
enst
ENST00000886737
resolver
enst
ENST00000886738
resolver
enst
ENST00000886739
resolver
enst
ENST00000886740
resolver
enst
ENST00000886741
resolver
enst
ENST00000886742
resolver
enst
ENST00000886744
resolver
enst
ENST00000886745
resolver
enst
ENST00000886746
resolver
enst
ENST00000886747
resolver
enst
ENST00000886751
resolver
enst
ENST00000886752
resolver
enst
ENST00000886754
resolver
enst
ENST00000886755
resolver
enst
ENST00000886757
resolver
enst
ENST00000886759
resolver
enst
ENST00000886761
resolver
enst
ENST00000886763
resolver
enst
ENST00000886764
resolver
enst
ENST00000886765
resolver
enst
ENST00000886766
resolver
enst
ENST00000886767
resolver
enst
ENST00000886769
resolver
enst
ENST00000886773
resolver
enst
ENST00000886774
resolver
enst
ENST00000886775
resolver
enst
ENST00000886776
resolver
enst
ENST00000886777
resolver
enst
ENST00000886778
resolver
enst
ENST00000913039
resolver
enst
ENST00000913040
resolver
enst
ENST00000913041
resolver
enst
ENST00000913042
resolver
enst
ENST00000913043
resolver
enst
ENST00000913044
resolver
enst
ENST00000913045
resolver
enst
ENST00000913047
resolver
enst
ENST00000913048
resolver
enst
ENST00000913050
resolver
enst
ENST00000913052
resolver
enst
ENST00000913053
resolver
enst
ENST00000913055
resolver
enst
ENST00000913057
resolver
enst
ENST00000913058
resolver
enst
ENST00000913059
resolver
enst
ENST00000913061
resolver
enst
ENST00000913063
resolver
enst
ENST00000964421
resolver
enst
ENST00000964422
resolver
enst
ENST00000964425
resolver
enst
ENST00000964426
resolver
enst
ENST00000964428
resolver
enst
ENST00000964429
resolver
enst
ENST00000964430
resolver
enst
ENST00000964431
resolver
enst
ENST00000964432
resolver
enst
ENST00000964433
resolver
enst
ENST00000964434
resolver
enst
ENST00000964435
resolver
enst
ENST00000964436
resolver
genesymbol
CERS4
resolver
genesymbol_syn
LASS4
resolver
hgnc
HGNC:23747
resolver
uniprot
D6W665
resolver
uniprot
Q53HF9
resolver
uniprot_entry
CERS4_HUMAN
resolver
uniprot_entry
Q53HF9_HUMAN
resolver
uniprot_sec
D6W665
resolver
amino_acid_sequence
MLSSFNEWFWQDRFWLPPNVTWTELEDRDGRVYPHPQDLLAALPLALVLLAMRLAFERFIGLPLSRWLGVRDQTRRQVKPNATLEKHFLTEGHRPKEPQLSLLAAQCGLTLQQTQRWFRRRRNQDRPQLTKKFCEASWRFLFYLSSFVGGLSVLYHESWLWAPVMCWDRYPNQTLKPSLYWWYLLELGFYLSLLIRLPFDVKRKDFKEQVIHHFVAVILMTFSYSANLLRIGSLVLLLHDSSDYLLEACKMVNYMQYQQVCDALFLIFSFVFFYTRLVLFPTQILYTTYYESISNRGPFFGYYFFNGLLMLLQLLHVFWSCLILRMLYSFMKKGQMEKDIRSDVEESDSSEEAAAAQEPLQLKNGAAGGPRPAPTDGPRSRVAGRLTNRHTTAT
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
ec_number
2.3.1.24
uniprot
proteins
function
FUNCTION: Ceramide synthase that catalyzes formation of ceramide from sphinganine and acyl-CoA substrates, with high selectivity toward long and very-long chains (C18:0-C22:0) as acyl donor. {ECO:0000269|PubMed:17977534, ECO:0000269|PubMed:23530041, ECO:0000269|PubMed:26887952, ECO:0000269|PubMed:29632068, ECO:0000269|PubMed:31916624}.
uniprot
proteins
mass_dalton
46399
uniprot
proteins
mutagenesis
MUTAGEN 291..298; /note="ESISNRGP->YPLELYPA: Altered specificity toward acyl donor; generates C24 ceramides instead of C18-C22-ceramides."; /evidence="ECO:0000269|PubMed:29632068"; MUTAGEN 342..350; /note="SDVEESDSS->ADVEEADAA: Decreased phosphorylation."; /evidence="ECO:0000269|PubMed:26887952
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; sphingolipid metabolism. {ECO:0000269|PubMed:17977534, ECO:0000269|PubMed:23530041, ECO:0000269|PubMed:26887952, ECO:0000269|PubMed:29632068}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at the C-terminus by CK2. {ECO:0000269|PubMed:26887952}.; PTM: N-glycosylated. {ECO:0000269|PubMed:26887952, ECO:0000269|PubMed:29632068}.
uniprot
proteins
protein_family
Sphingosine N-acyltransferase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17977534
uniprot
proteins
pubmed
23530041
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26887952
uniprot
proteins
pubmed
29632068
uniprot
proteins
pubmed
31916624
uniprot
proteins
sequence_length
394
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9D6J1}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..52; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 140..160; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 179..199; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 209..229; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 260..280; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 304..324; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins