Steap3
entrez
170824
canonical
uniprot
Q5RKL5
canonical
ensembl
ENSRNOG00000049471
resolver
ensembl
ENSRNOG00055012986
resolver
ensembl
ENSRNOG00060005740
resolver
ensembl
ENSRNOG00065009603
resolver
ensp
ENSRNOP00000064137
resolver
ensp
ENSRNOP00000092490
resolver
ensp
ENSRNOP00000095399
resolver
ensp
ENSRNOP00000105584
resolver
ensp
ENSRNOP00055018075
resolver
ensp
ENSRNOP00060007186
resolver
ensp
ENSRNOP00065011583
resolver
enst
ENSRNOT00000071388
resolver
enst
ENSRNOT00000101486
resolver
enst
ENSRNOT00000106336
resolver
enst
ENSRNOT00000123261
resolver
enst
ENSRNOT00055022261
resolver
enst
ENSRNOT00060009565
resolver
enst
ENSRNOT00065015402
resolver
genesymbol
Steap3
resolver
uniprot
A0A0H2UI26
resolver
uniprot
A0A8I6AGN2
resolver
uniprot
A0A8I6AMK0
resolver
uniprot
Q99P41
resolver
uniprot_entry
A0A0H2UI26_RAT
resolver
uniprot_entry
A0A8I6AGN2_RAT
resolver
uniprot_entry
A0A8I6AMK0_RAT
resolver
uniprot_entry
STEA3_RAT
resolver
uniprot_sec
Q99P41
resolver
amino_acid_sequence
MSGEMDKPLISRRLVDSDGSLAEVPKEAPKVGILGSGDFARSLATRLVGSGFSVVVGSRNPKRTAGLFPSLAQVTFQEEAVSSPEVIFVAVFREHYSSLCSLADQLAGKILVDVSNPTEKERLQHRQSNAEYLASLFPACTVVKAFNVISAWALQAGPRDGNRQVLICGDQLEAKHTVSEMARAMGFTPLDMGSLASAREVEAIPLRLLPSWKVPTLLALGLFVCFYAYNFIRDVLQPYIRKDENKFYKMPLSVVNTTLPCVAYVLLSLVYLPGVLAAALQLRRGTKYQRFPDWLDHWLQHRKQIGLLSFFFAMLHALYSFCLPLRRSHRYDLVNLAVKQVLANKSRLWVEEEVWRMEIYLSLGVLALGMLSLLAVTSIPSIANSLNWKEFSFVQSTLGFVALMLSTMHTLTYGWTRAFEENHYKFYLPPTFTLTLLLPCVIILAKGLFLLPCLSHRLTKIRRGWERDGAVKFMLPAGHTQGEKTSHV
uniprot
proteins
ec_number
1.16.1.-
uniprot
proteins
function
FUNCTION: Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (By similarity). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (By similarity). Mediates efficient transferrin-dependent iron uptake in erythroid cells (By similarity). May play a role downstream of p53/TP53 to interface apoptosis and cell cycle progression (PubMed:11593405). Indirectly involved in exosome secretion by facilitating the secretion of proteins such as TCTP (By similarity). {ECO:0000250|UniProtKB:Q658P3, ECO:0000250|UniProtKB:Q687X5, ECO:0000250|UniProtKB:Q8CI59, ECO:0000269|PubMed:11593405}.
uniprot
proteins
mass_dalton
54674
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved by RHBDL4/RHBDD1. RHBDL4/RHBDD1-induced cleavage occurs at multiple sites in a glycosylation-independent manner (By similarity). {ECO:0000250|UniProtKB:Q658P3}.; PTM: Glycosylated. {ECO:0000250|UniProtKB:Q658P3}.
uniprot
proteins
protein_family
STEAP family
uniprot
proteins
pubmed
10969787
uniprot
proteins
pubmed
11593405
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
488
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:Q8CI59}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 208..228; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 259..279; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 305..325; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 359..379; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 391..411; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 434..454; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins