POLR2G
entrez
5436
canonical
uniprot
P62487
canonical
ensembl
ENSG00000168002
resolver
ensp
ENSP00000301788
resolver
enst
ENST00000301788
resolver
genesymbol
POLR2G
resolver
genesymbol_syn
RPB7
resolver
hgnc
HGNC:9194
resolver
uniprot
B2R5C0
resolver
uniprot
P52433
resolver
uniprot
Q2M1Z4
resolver
uniprot_entry
RPB7_HUMAN
resolver
uniprot_sec
B2R5C0
resolver
uniprot_sec
P52433
resolver
uniprot_sec
Q2M1Z4
resolver
amino_acid_sequence
MFYHISLEHEILLHPRYFGPNLLNTVKQKLFTEVEGTCTGKYGFVIAVTTIDNIGAGVIQPGRGFVLYPVKYKAIVFRPFKGEVVDAVVTQVNKVGLFTEIGPMSCFISRHSIPSEMEFDPNSNPPCYKTMDEDIVIQQDDEIRLKIVGTRVDKNDIFAIGSLMDDYLGLVS
uniprot
proteins
function
FUNCTION: Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. POLR2G/RPB7 is part of a subcomplex with POLR2D/RPB4 that binds to a pocket formed by POLR2A/RPB1, POLR2B/RPB2 and POLR2F/RPABC2 at the base of the clamp element. The POLR2D/RPB4-POLR2G/RPB7 subcomplex seems to lock the clamp via POLR2G/RPB7 in the closed conformation thus preventing double-stranded DNA to enter the active site cleft. The POLR2D/RPB4-POLR2G/RPB7 subcomplex binds single-stranded DNA and RNA. {ECO:0000250|UniProtKB:P34087, ECO:0000269|PubMed:16282592, ECO:0000269|PubMed:27193682, ECO:0000269|PubMed:30190596, ECO:0000269|PubMed:9852112}.
uniprot
proteins
mass_dalton
19294
uniprot
proteins
mutagenesis
MUTAGEN 14; /note="H->E: Strongly reduces RNA-binding."; /evidence="ECO:0000269|PubMed:16282592"; MUTAGEN 33; /note="E->K: Strongly reduces RNA-binding."; /evidence="ECO:0000269|PubMed:16282592"; MUTAGEN 41; /note="K->E: Strongly reduces RNA-binding."; /evidence="ECO:0000269|PubMed:16282592"; MUTAGEN 90; /note="T->A: Reduces RNA-binding."; /evidence="ECO:0000269|PubMed:16282592"; MUTAGEN 93; /note="N->A: Reduces RNA-binding."; /evidence="ECO:0000269|PubMed:16282592"; MUTAGEN 94; /note="K->E: Reduces RNA-binding."; /evidence="ECO:0000269|PubMed:16282592"; MUTAGEN 107; /note="F->E: Reduces RNA-binding."; /evidence="ECO:0000269|PubMed:16282592"; MUTAGEN 109; /note="S->A: Strongly reduces RNA-binding."; /evidence="ECO:0000269|PubMed:16282592"; MUTAGEN 111; /note="H->E: Strongly reduces RNA-binding."; /evidence="ECO:0000269|PubMed:16282592"; MUTAGEN 151; /note="R->E: Strongly reduces RNA-binding."; /evidence="ECO:0000269|PubMed:16282592"; MUTAGEN 153; /note="D->E: Strongly reduces RNA-binding."; /evidence="ECO:0000269|PubMed:16282592"; MUTAGEN 158; /note="F->A: Strongly reduces RNA-binding."; /evidence="ECO:0000269|PubMed:16282592
uniprot
proteins
protein_family
Eukaryotic RPB7/RPC8 RNA polymerase subunit family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16282592
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
27193682
uniprot
proteins
pubmed
30190596
uniprot
proteins
pubmed
7579693
uniprot
proteins
pubmed
9256063
uniprot
proteins
pubmed
9852112
uniprot
proteins
sequence_length
172
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9852112}.
uniprot
proteins