Alox12e
entrez
303252
canonical
uniprot
D3ZQF9
canonical
ensembl
ENSRNOG00000019074
resolver
ensp
ENSRNOP00000025910
resolver
enst
ENSRNOT00000025910
resolver
genesymbol
Alox12e
resolver
uniprot_entry
LX12E_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Arachidonate 12-lipoxygenase activity is decreased when the pH decreases from 7.4 to 6.0. {ECO:0000250|UniProtKB:P55249}.
uniprot
proteins
amino_acid_sequence
MGKYKILVVTGDSLLAGSTNLVQLWLVGEHAEADLGKQLRPLRGRKTELEIDVPLHLGRLLVVKLRKHKGLLDSDWFCKWITVQGPGIQGEAFFPCYSWVQGKETIYLPEGTALKVNDDTKNLFRKYREQELEDRRNVYRWGSWKEGLILPIAGSTERDLPRNQRFMEDKDLDFSLSLAKVLKDFAIKGTLDFVSRVQHLEDYQKVFPHSKTALAGRVRDSWKEDALFGYQFLNGANPMLLRRSKRLPARLVLPPGMEDLQTQLEKELKAGSLFEADFSLLDGVKPNVIIFKQQHVAAPLVMLKLQSDGRLLPMVIQLQPPRHGCPPPLLFLPSDPPMAWLLAKIWVRSSDFQVHQLQSHLLRGHLMAEVISVATMRSLPSLHPIYKLLAPHFRYTMEINTLARNNLVSEWGIFDLVVSTGSGGHVDILQRATACLTYRSFCPPDDLADRGLLDVKSSLYARDALRLWEIISRYVGRMVELFYKNDREVKEDPELQVWCREVTEIGLLGAQDRGFPLSLESRAQLCRFVTMCIFTCTGQHASTHLGQLDWYSWIPNGPCTMRKPPPTSKNVTEGDILDALPCLQQARMQITFTKFLGRHQPVMVALGQHKEEYFSDPGARAVLKQFQEELAVMDKEIEVRNASLDLPYEYLRPSMVENSVTI
uniprot
proteins
ec_number
1.13.11.-
uniprot
proteins
ec_number
1.13.11.31
uniprot
proteins
function
FUNCTION: Catalyzes the regio and stereo-specific incorporation of a single molecule of dioxygen into free and esterified polyunsaturated fatty acids generating lipid hydroperoxides that can be further reduced to the corresponding hydroxy species (PubMed:23382512). Shows increasing catalytic activity within the series arachidonic acid < 5,8,11-eicosatrienoic acid < linoleic acid < 8,11,14-eicosatrienoic acid (By similarity). {ECO:0000250|UniProtKB:P55249, ECO:0000269|PubMed:23382512}.
uniprot
proteins
mass_dalton
75466
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis.
uniprot
proteins
protein_family
Lipoxygenase family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
23382512
uniprot
proteins
sequence_length
662
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|PROSITE-ProRule:PRU00726}.
uniprot
proteins