CES3
entrez
23491
canonical
uniprot
Q6UWW8
canonical
ensembl
ENSG00000172828
resolver
ensp
ENSP00000304782
resolver
ensp
ENSP00000377602
resolver
ensp
ENSP00000445559
resolver
enst
ENST00000394037
resolver
genesymbol
CES3
resolver
hgnc
HGNC:1865
resolver
uniprot
A0A0C4DFY7
resolver
uniprot
B2Z3W9
resolver
uniprot
F5H242
resolver
uniprot
Q7Z6J1
resolver
uniprot
Q9H6X7
resolver
uniprot_entry
A0A0C4DFY7_HUMAN
resolver
uniprot_entry
EST3_HUMAN
resolver
uniprot_sec
B2Z3W9
resolver
uniprot_sec
F5H242
resolver
uniprot_sec
Q7Z6J1
resolver
uniprot_sec
Q9H6X7
resolver
amino_acid_sequence
MERAVRVESGVLVGVVCLLLACPATATGPEVAQPEVDTTLGRVRGRQVGVKGTDRLVNVFLGIPFAQPPLGPDRFSAPHPAQPWEGVRDASTAPPMCLQDVESMNSSRFVLNGKQQIFSVSEDCLVLNVYSPAEVPAGSGRPVMVWVHGGALITGAATSYDGSALAAYGDVVVVTVQYRLGVLGFFSTGDEHAPGNQGFLDVVAALRWVQENIAPFGGDLNCVTVFGGSAGGSIISGLVLSPVAAGLFHRAITQSGVITTPGIIDSHPWPLAQKIANTLACSSSSPAEMVQCLQQKEGEELVLSKKLKNTIYPLTVDGTVFPKSPKELLKEKPFHSVPFLMGVNNHEFSWLIPRGWGLLDTMEQMSREDMLAISTPVLTSLDVPPEMMPTVIDEYLGSNSDAQAKCQAFQEFMGDVFINVPTVSFSRYLRDSGSPVFFYEFQHRPSSFAKIKPAWVKADHGAEGAFVFGGPFLMDESSRLAFPEATEEEKQLSLTMMAQWTHFARTGDPNSKALPPWPQFNQAEQYLEINPVPRAGQKFREAWMQFWSETLPSKIQQWHQKQKNRKAQEDL
uniprot
proteins
ec_number
3.1.1.1
uniprot
proteins
function
FUNCTION: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics.
uniprot
proteins
mass_dalton
62282
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:15100172, ECO:0000269|PubMed:19159218}.
uniprot
proteins
protein_family
Type-B carboxylesterase/lipase family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14581373
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15100172
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
15687373
uniprot
proteins
pubmed
19159218
uniprot
proteins
sequence_length
571
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000250}.
uniprot
proteins