CLDN8
entrez
9073
canonical
uniprot
P56748
canonical
ensembl
ENSG00000156284
resolver
ensp
ENSP00000382783
resolver
enst
ENST00000399899
resolver
genesymbol
CLDN8
resolver
genesymbol
HEL-S-79
resolver
hgnc
HGNC:2050
resolver
uniprot
A0A0K0K1I9
resolver
uniprot
D3DSE3
resolver
uniprot
Q53EX7
resolver
uniprot_entry
A0A0K0K1I9_HUMAN
resolver
uniprot_entry
CLD8_HUMAN
resolver
uniprot_sec
D3DSE3
resolver
uniprot_sec
Q53EX7
resolver
amino_acid_sequence
MATHALEIAGLFLGGVGMVGTVAVTVMPQWRVSAFIENNIVVFENFWEGLWMNCVRQANIRMQCKIYDSLLALSPDLQAARGLMCAASVMSFLAFMMAILGMKCTRCTGDNEKVKAHILLTAGIIFIITGMVVLIPVSWVANAIIRDFYNSIVNVAQKRELGEALYLGWTTALVLIVGGALFCCVFCCNEKSSSYRYSIPSHRTTQKSYHTGKKSPSVYSRSQYV
uniprot
proteins
function
FUNCTION: Can associate with other claudins to regulate tight junction structural and functional strand dynamics (By similarity). May coassemble with CLDN4 into tight junction strands containing anion-selective channels that convey paracellular chloride permeability in renal collecting ducts (By similarity) (PubMed:36008380). Cannot form tight junction strands on its own (PubMed:36008380). {ECO:0000250|UniProtKB:Q9Z260, ECO:0000269|PubMed:36008380}.
uniprot
proteins
mass_dalton
24845
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the BCR(KLHL3) E3 ubiquitin ligase complex in the kidney, leading to its degradation. {ECO:0000250|UniProtKB:Q9Z260}.
uniprot
proteins
protein_family
Claudin family
uniprot
proteins
pubmed
10830953
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17287494
uniprot
proteins
pubmed
36008380
uniprot
proteins
sequence_length
225
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000269|PubMed:17287494}. Cell membrane {ECO:0000250|UniProtKB:Q9Z260}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes to tight junctions in all 3 segments of the epididymis, in the caput found in the lateral margins of principal cells, and in the corpus at the interface between basal and principal cells. {ECO:0000269|PubMed:17287494}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..28; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 82..102; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 118..138; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 167..187; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins