Gabrd
entrez
29689
canonical
uniprot
P18506
canonical
ensembl
ENSRNOG00000016385
resolver
ensembl
ENSRNOG00055015394
resolver
ensembl
ENSRNOG00060004253
resolver
ensembl
ENSRNOG00065009720
resolver
ensp
ENSRNOP00000022246
resolver
ensp
ENSRNOP00055021382
resolver
ensp
ENSRNOP00060005381
resolver
ensp
ENSRNOP00065011794
resolver
enst
ENSRNOT00055026305
resolver
enst
ENSRNOT00060007122
resolver
enst
ENSRNOT00065015625
resolver
genesymbol
Gabrd
resolver
uniprot_entry
GBRD_RAT
resolver
amino_acid_sequence
MDVLGWLLLPLLLLCTQPHHGARAMNDIGDYVGSNLEISWLPNLDGLMEGYARNFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYNHTNETLGLDSRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVACDMDLAKYPMDEQECMLDLESYGYSSEDIVYYWSENQEQIHGLDRLQLAQFTITSYRFTTELMNFKSAGQFPRLSLHFQLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLGITTVLTMTTLMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHFNADYRKKRKAKVKVTKPRAEMDVRNAIVLFSLSAAGVSQELAISRRQGRVPGNLMGSYRSVEVEAKKEGGSRPGGPGGIRSRLKPIDADTIDIYARAVFPAAFAAVNIIYWAAYTM
uniprot
proteins
function
FUNCTION: Delta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (By similarity). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). GABAARs containing delta/GABRD subunits are predominantly expressed and located in extrasynaptic or perisynaptic positions on hippocampus and cerebellar granule cells, and contribute to the tonic GABAergic inhibition (PubMed:9464994). GABAAR containing alpha-4-beta-3-delta subunits can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (By similarity). {ECO:0000250|UniProtKB:O14764, ECO:0000269|PubMed:9464994}.
uniprot
proteins
mass_dalton
50566
uniprot
proteins
protein_family
GABRD sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1690000
uniprot
proteins
pubmed
17003036
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2561970
uniprot
proteins
pubmed
8195163
uniprot
proteins
pubmed
9464994
uniprot
proteins
sequence_length
449
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9464994}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O14764}. Note=Delta subunits are found only on the extrasynaptic somatic and dendritic membranes. {ECO:0000269|PubMed:9464994}.
uniprot
proteins
transmembrane_region
TRANSMEM 252..271; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O14764"; TRANSMEM 276..298; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O14764"; TRANSMEM 309..331; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O14764"; TRANSMEM 424..446; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O14764
uniprot
proteins