Opn1mw
entrez
89810
canonical
uniprot
O35476
canonical
ensembl
ENSRNOG00000051529
resolver
ensembl
ENSRNOG00055025092
resolver
ensembl
ENSRNOG00060006687
resolver
ensembl
ENSRNOG00065014896
resolver
ensp
ENSRNOP00000089832
resolver
ensp
ENSRNOP00055035275
resolver
ensp
ENSRNOP00060008163
resolver
ensp
ENSRNOP00065019224
resolver
enst
ENSRNOT00000109312
resolver
enst
ENSRNOT00055043244
resolver
enst
ENSRNOT00060010959
resolver
enst
ENSRNOT00065024634
resolver
genesymbol
Opn1mw
resolver
genesymbol_syn
Gcp
resolver
uniprot_entry
OPSG_RAT
resolver
amino_acid_sequence
MAQQLTGEQTLDHYEDSTQASIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSTWMILVVIASVFTNGLVLAATMRFKKLRHPLNWILVNLAVADLAETIIASTISVVNQIYGYFVLGHPLCVIEGYIVSLCGITGLWSLAIISWERWLVVCKPFGNVRFDAKLATVGIVFSWVWAAVWTAPPIFGWSRYWPYGLKTSCGPDVFSGTSYPGVQSYMMVLMVTCCIFPLSIIVLCYLQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMVFAYCLCWGPYTFFACFATAHPGYAFHPLVASLPSYFAKSATIYNPIIYVFMNRQFRNCILQLFGKKVDDSSELSSTSKTEVSSVSSVSPA
uniprot
proteins
function
FUNCTION: G protein-coupled photoreceptor that selectively activates transducin G alpha protein (G(t)) in response to medium-wavelength (green) light, thereby stimulating the G(t)/transducin protein pathway (By similarity). This activation leads to increased cGMP phosphodiesterase activity, resulting in decreased intracellular cGMP and subsequent closure of cGMP-gated ion channels. The process is initiated when the opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers the G protein-mediated phototransduction cascade (By similarity). Mediates visual perception of green light in cone photoreceptor cells (By similarity). {ECO:0000250|UniProtKB:P04000, ECO:0000250|UniProtKB:P04001}.
uniprot
proteins
mass_dalton
40200
uniprot
proteins
post_translational_modification
PTM: O-glycosylated. {ECO:0000250|UniProtKB:O35599}.; PTM: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region. {ECO:0000250|UniProtKB:P04001}.; PTM: Contains one retinal chromophore covalently bound to a lysine residue via a Schiff base. Upon light absorption, the bound 11-cis-retinal isomerizes to all-trans-retinal. Following activation, the covalently bound all-trans-retinal is released through hydrolysis of the Schiff base, and OPN1 is regenerated by binding a new 11-cis-retinal molecule. {ECO:0000250|UniProtKB:P04001}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Opsin subfamily
uniprot
proteins
pubmed
6233288
uniprot
proteins
pubmed
9580985
uniprot
proteins
pubmed
9751808
uniprot
proteins
sequence_length
359
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P04001}; Multi-pass membrane protein {ECO:0000255}. Photoreceptor outer segment membrane {ECO:0000250|UniProtKB:O35599}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 48..72; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 85..110; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 125..144; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 164..187; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 214..241; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 264..287; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 296..320; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins