FNDC4
entrez
64838
canonical
uniprot
Q9H6D8
canonical
ensembl
ENSG00000115226
resolver
ensp
ENSP00000264703
resolver
ensp
ENSP00000604184
resolver
ensp
ENSP00000621281
resolver
ensp
ENSP00000667061
resolver
enst
ENST00000264703
resolver
enst
ENST00000934125
resolver
enst
ENST00000951222
resolver
genesymbol
FNDC4
resolver
genesymbol_syn
FRCP1
resolver
hgnc
HGNC:20239
resolver
uniprot
D6W560
resolver
uniprot_entry
FNDC4_HUMAN
resolver
uniprot_sec
D6W560
resolver
amino_acid_sequence
MPSGCHSSPPSGLRGDMASLVPLSPYLSPTVLLLVSCDLGFVRADRPPSPVNVTVTHLRANSATVSWDVPEGNIVIGYSISQQRQNGPGQRVIREVNTTTRACALWGLAEDSDYTVQVRSIGLRGESPPGPRVHFRTLKGSDRLPSNSSSPGDITVEGLDGERPLQTGEVVIIVVVLLMWAAVIGLFCRQYDIIKDNDSNNNPKEKGKGPEQSPQGRPVGTRQKKSPSINTIDV
uniprot
proteins
function
FUNCTION: [Soluble FNDC4]: Has anti-inflammatory properties. In the colon, acts on macrophages to down-regulate inflammation. May suppress osteoclastogenesis and mature osteoclast resorptive function. In white adipose tissue, decreases local inflammation, via interaction with GPR116. Also required for proper systemic glucose tolerance, specifically sensitizing white adipocytes to insulin and promoting glucose uptake. The insulin sensitizing function in adipose tissue is mediated by interaction with ADGRF5/GPR116 and activation of cAMP signaling. {ECO:0000250|UniProtKB:Q3TR08}.
uniprot
proteins
mass_dalton
25159
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
27066907
uniprot
proteins
pubmed
34016966
uniprot
proteins
sequence_length
234
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Fibronectin type III domain-containing protein 4]: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Soluble FNDC4]: Secreted {ECO:0000250|UniProtKB:Q3TR08}.
uniprot
proteins
transmembrane_region
TRANSMEM 168..188; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins