PPARGC1B
entrez
133522
canonical
uniprot
Q86YN6
canonical
ensembl
ENSG00000155846
resolver
ensp
ENSP00000312649
resolver
ensp
ENSP00000353638
resolver
ensp
ENSP00000384403
resolver
ensp
ENSP00000554624
resolver
ensp
ENSP00000666914
resolver
genesymbol
PPARGC1B
resolver
genesymbol_syn
PERC
resolver
genesymbol_syn
PGC1
resolver
genesymbol_syn
PGC1B
resolver
genesymbol_syn
PPARGC1
resolver
hgnc
HGNC:30022
resolver
uniprot
A2RUM8
resolver
uniprot
A2RUN0
resolver
uniprot
B3KVW0
resolver
uniprot
B7ZM40
resolver
uniprot
Q86YN3
resolver
uniprot
Q86YN4
resolver
uniprot
Q86YN5
resolver
uniprot
Q8N1N9
resolver
uniprot
Q8TDE4
resolver
uniprot
Q8TDE5
resolver
uniprot_entry
B7ZM40_HUMAN
resolver
uniprot_entry
PRGC2_HUMAN
resolver
uniprot_sec
A2RUM8
resolver
uniprot_sec
A2RUN0
resolver
uniprot_sec
B3KVW0
resolver
uniprot_sec
Q86YN3
resolver
uniprot_sec
Q86YN4
resolver
uniprot_sec
Q86YN5
resolver
uniprot_sec
Q8N1N9
resolver
uniprot_sec
Q8TDE4
resolver
uniprot_sec
Q8TDE5
resolver
amino_acid_sequence
MAGNDCGALLDEELSSFFLNYLADTQGGGSGEEQLYADFPELDLSQLDASDFDSATCFGELQWCPENSETEPNQYSPDDSELFQIDSENEALLAELTKTLDDIPEDDVGLAAFPALDGGDALSCTSASPAPSSAPPSPAPEKPSAPAPEVDELSLLQKLLLATSYPTSSSDTQKEGTAWRQAGLRSKSQRPCVKADSTQDKKAPMMQSQSRSCTELHKHLTSAQCCLQDRGLQPPCLQSPRLPAKEDKEPGEDCPSPQPAPASPRDSLALGRADPGAPVSQEDMQAMVQLIRYMHTYCLPQRKLPPQTPEPLPKACSNPSQQVRSRPWSRHHSKASWAEFSILRELLAQDVLCDVSKPYRLATPVYASLTPRSRPRPPKDSQASPGRPSSVEEVRIAASPKSTGPRPSLRPLRLEVKREVRRPARLQQQEEEDEEEEEEEEEEEKEEEEEWGRKRPGRGLPWTKLGRKLESSVCPVRRSRRLNPELGPWLTFADEPLVPSEPQGALPSLCLAPKAYDVERELGSPTDEDSGQDQQLLRGPQIPALESPCESGCGDMDEDPSCPQLPPRDSPRCLMLALSQSDPTFGKKSFEQTLTVELCGTAGLTPPTTPPYKPTEEDPFKPDIKHSLGKEIALSLPSPEGLSLKATPGAAHKLPKKHPERSELLSHLRHATAQPASQAGQKRPFSCSFGDHDYCQVLRPEGVLQRKVLRSWEPSGVHLEDWPQQGAPWAEAQAPGREEDRSCDAGAPPKDSTLLRDHEIRASLTKHFGLLETALEEEDLASCKSPEYDTVFEDSSSSSGESSFLPEEEEEEGEEEEEDDEEEDSGVSPTCSDHCPYQSPPSKANRQLCSRSRSSSGSSPCHSWSPATRRNFRCESRGPCSDRTPSIRHARKRREKAIGEGRVVYIQNLSSDMSSRELKRRFEVFGEIEECEVLTRNRRGEKYGFITYRCSEHAALSLTKGAALRKRNEPSFQLSYGGLRHFCWPRYTDYDSNSEEALPASGKSKYEAMDFDSLLKEAQQSLH
uniprot
proteins
function
FUNCTION: Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. {ECO:0000269|PubMed:11854298, ECO:0000269|PubMed:12678921, ECO:0000269|PubMed:15546003, ECO:0000269|PubMed:23836911}.
uniprot
proteins
mass_dalton
113222
uniprot
proteins
mutagenesis
MUTAGEN 92..96; /note="LLAEL->AAAEA: Reduces DNA transcriptional activity."; /evidence="ECO:0000269|PubMed:11854298"; MUTAGEN 155..160; /note="LLQKLL->AAQKAA: Reduces interaction and activation of ESR1. Loss of interaction and activation of ESR1; when associated with 343-AREAA-347."; /evidence="ECO:0000269|PubMed:11854298"; MUTAGEN 343..347; /note="LRELL->AREAA: Reduces interaction and activation of ESR1. Loss of interaction and activation of ESR1; when associated with 155-AAQKAA-160."; /evidence="ECO:0000269|PubMed:11854298
uniprot
proteins
pubmed
11854298
uniprot
proteins
pubmed
12678921
uniprot
proteins
pubmed
12832613
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15546003
uniprot
proteins
pubmed
15863669
uniprot
proteins
pubmed
16132959
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23836911
uniprot
proteins
sequence_length
1023
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11854298}.
uniprot
proteins