Aqp2
entrez
25386
canonical
uniprot
P34080
canonical
ensembl
ENSRNOG00000054378
resolver
ensp
ENSRNOP00000074297
resolver
genesymbol
Aqp2
resolver
uniprot
A1A5L4
resolver
uniprot_entry
AQP2_RAT
resolver
uniprot_sec
A1A5L4
resolver
amino_acid_sequence
MWELRSIAFSRAVLAEFLATLLFVFFGLGSALQWASSPPSVLQIAVAFGLGIGILVQALGHVSGAHINPAVTVACLVGCHVSFLRAAFYVAAQLLGAVAGAAILHEITPVEIRGDLAVNALHNNATAGQAVTVELFLTMQLVLCIFASTDERRGDNLGSPALSIGFSVTLGHLLGIYFTGCSMNPARSLAPAVVTGKFDDHWVFWIGPLVGAIIGSLLYNYLLFPSAKSLQERLAVLKGLEPDTDWEEREVRRRQSVELHSPQSLPRGSKA
uniprot
proteins
function
FUNCTION: Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient (PubMed:7508187, PubMed:8429910). Plays an essential role in renal water homeostasis (By similarity). Could also be permeable to glycerol (By similarity). {ECO:0000250|UniProtKB:P41181, ECO:0000269|PubMed:7508187, ECO:0000269|PubMed:8429910}.
uniprot
proteins
mass_dalton
28931
uniprot
proteins
post_translational_modification
PTM: Ser-256 phosphorylation is necessary and sufficient for expression at the apical membrane. Endocytosis is not phosphorylation-dependent. {ECO:0000250|UniProtKB:P41181}.; PTM: N-glycosylated. {ECO:0000250|UniProtKB:P41181}.
uniprot
proteins
protein_family
MIP/aquaporin (TC 1.A.8) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
19794145
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7505572
uniprot
proteins
pubmed
7508187
uniprot
proteins
pubmed
8429910
uniprot
proteins
sequence_length
271
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:19794145, ECO:0000269|PubMed:8429910}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P41181}. Basolateral cell membrane {ECO:0000269|PubMed:19794145}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P41181}. Cell membrane {ECO:0000269|PubMed:7508187}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P41181}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:19794145}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P41181}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:19794145}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P41181}. Note=Shuttles from vesicles to the apical membrane. Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane. PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated. {ECO:0000269|PubMed:19794145}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P41181"; TRANSMEM 41..59; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P41181"; TRANSMEM 86..107; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P41181"; TRANSMEM 128..148; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P41181"; TRANSMEM 157..176; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P41181"; TRANSMEM 202..222; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P41181
uniprot
proteins