Kcnn3
entrez
54263
canonical
uniprot
P70605
canonical
ensembl
ENSRNOG00000020706
resolver
ensembl
ENSRNOG00065027232
resolver
ensp
ENSRNOP00000028117
resolver
ensp
ENSRNOP00065038553
resolver
enst
ENSRNOT00000028117
resolver
enst
ENSRNOT00065046973
resolver
genesymbol
Kcnn3
resolver
uniprot
G3V8S7
resolver
uniprot
Q9EQ81
resolver
uniprot
Q9ERQ4
resolver
uniprot_entry
G3V8S7_RAT
resolver
uniprot_entry
KCNN3_RAT
resolver
uniprot_sec
Q9EQ81
resolver
uniprot_sec
Q9ERQ4
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by bee venom neurotoxin apamin. {ECO:0000269|PubMed:11245600, ECO:0000269|PubMed:11533126}.
uniprot
proteins
amino_acid_sequence
MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQPPPPSAPPAVPQQPPGPLLQPQPPQLQQQQQQQQQQQQQQQQQQQAPLHPLPQLAQLQSQLVHPGLLHSSPTAFRAPNSANSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAEPEGQPLQLFSPSNPPEIIISSREDNHAHQTLLHHPNATHNHQHAGTTAGSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRGVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLTAFVEARGISVAVGTSHAPPSDSPIGISSTSFPTPYTSSSSC
uniprot
proteins
function
FUNCTION: Small conductance calcium-activated potassium channel that mediates the voltage-independent transmembrane transfer of potassium across the cell membrane through a constitutive interaction with calmodulin which binds the intracellular calcium allowing its opening (PubMed:11245600, PubMed:11533126). The current is characterized by a voltage-independent activation, an intracellular calcium concentration increase-dependent activation and a single-channel conductance of 10 picosiemens (PubMed:11245600, PubMed:11533126). Also presents an inwardly rectifying current, thus reducing its already small outward conductance of potassium ions, which is particularly the case when the membrane potential displays positive values, above + 20 mV (By similarity). Activation is followed by membrane hyperpolarization (PubMed:11533126). Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization (PubMed:11533126). {ECO:0000250|UniProtKB:Q9UGI6, ECO:0000269|PubMed:11245600, ECO:0000269|PubMed:11533126}.
uniprot
proteins
mass_dalton
81448
uniprot
proteins
protein_family
KCa2.3/KCNN3 subfamily
uniprot
proteins
protein_family
Potassium channel KCNN family
uniprot
proteins
pubmed
11245600
uniprot
proteins
pubmed
11533126
uniprot
proteins
pubmed
14559917
uniprot
proteins
pubmed
8781233
uniprot
proteins
sequence_length
732
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11245600, ECO:0000269|PubMed:14559917}; Multi-pass membrane protein. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250|UniProtKB:P58391}.
uniprot
proteins
transmembrane_region
TRANSMEM 289..309; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 316..336; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 367..387; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 406..426; /note="Helical; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 455..475; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 524..544; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins