Akr1b1
entrez
11677
canonical
uniprot
P45376
canonical
ensembl
ENSMUSG00000001642
resolver
ensp
ENSMUSP00000100045
resolver
enst
ENSMUST00000102980
resolver
genesymbol
Akr1b1
resolver
genesymbol_syn
Akr1b3
resolver
genesymbol_syn
Aldor1
resolver
genesymbol_syn
Aldr1
resolver
genesymbol_syn
Alr2
resolver
uniprot
O70130
resolver
uniprot
Q3UDY1
resolver
uniprot
Q99KC9
resolver
uniprot_entry
ALDR_MOUSE
resolver
uniprot_entry
Q3UDY1_MOUSE
resolver
uniprot_sec
O70130
resolver
uniprot_sec
Q99KC9
resolver
activity_regulation
ACTIVITY REGULATION: Cys-299 acts as a redox-sensitive regulatory site. Its thiol group undergoes reversible oxidative and nitrosative modifications (S-nitrosylation, S-glutathiolation) that modulate enzyme activity, linking AKR1B1 function to the cellular redox environment. Tolrestat inhibits retinal reduction. {ECO:0000250|UniProtKB:P15121}.
uniprot
proteins
amino_acid_sequence
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDLGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDKSMVKGAFQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKTIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPVRIAENLKVFDFEVSSEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
uniprot
proteins
ec_number
1.1.1.21
uniprot
proteins
ec_number
1.1.1.300
uniprot
proteins
ec_number
1.1.1.372
uniprot
proteins
ec_number
1.1.1.54
uniprot
proteins
function
FUNCTION: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:17381426, PubMed:19010934, PubMed:7851421). Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides, bile acids and xenobiotics substrates (PubMed:17381426, PubMed:19010934, PubMed:7851421). It catalyzes the reduction of glucose to sorbitol, the first step of the polyol pathway, an alternative route of glucose metabolism that converts glucose to fructose. This pathway becomes highly active under elevated glucose levels, such as during hyperglycemia (By similarity). Reduces steroids and their derivatives and prostaglandins (PubMed:19010934). Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides (PubMed:17381426). Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (By similarity). {ECO:0000250|UniProtKB:P15121, ECO:0000269|PubMed:17381426, ECO:0000269|PubMed:19010934, ECO:0000269|PubMed:7851421}.
uniprot
proteins
mass_dalton
35732
uniprot
proteins
protein_family
Aldo/keto reductase family
uniprot
proteins
pubmed
10049784
uniprot
proteins
pubmed
10092857
uniprot
proteins
pubmed
10913167
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17381426
uniprot
proteins
pubmed
19010934
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7851421
uniprot
proteins
pubmed
9485485
uniprot
proteins
sequence_length
316
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins