Efnb2
entrez
13642
canonical
uniprot
P52800
canonical
ensembl
ENSMUSG00000001300
resolver
ensp
ENSMUSP00000001319
resolver
enst
ENSMUST00000001319
resolver
genesymbol
Efnb2
resolver
genesymbol_syn
Elf2
resolver
genesymbol_syn
Epl5
resolver
genesymbol_syn
Eplg5
resolver
genesymbol_syn
Htkl
resolver
genesymbol_syn
Lerk5
resolver
uniprot
Q4FJM3
resolver
uniprot_entry
EFNB2_MOUSE
resolver
uniprot_entry
Q4FJM3_MOUSE
resolver
amino_acid_sequence
MAMARSRRDSVWKYCWGLLMVLCRTAISRSIVLEPIYWNSSNSKFLPGQGLVLYPQIGDKLDIICPKVDSKTVGQYEYYKVYMVDKDQADRCTIKKENTPLLNCARPDQDVKFTIKFQEFSPNLWGLEFQKNKDYYIISTSNGSLEGLDNQEGGVCQTRAMKILMKVGQDASSAGSARNHGPTRRPELEAGTNGRSSTTSPFVKPNPGSSTDGNSAGHSGNNLLGSEVALFAGIASGCIIFIVIIITLVVLLLKYRRRHRKHSPQHTTTLSLSTLATPKRGGNNNGSEPSDVIIPLRTADSVFCPHYEKVSGDYGHPVYIVQEMPPQSPANIYYKV
uniprot
proteins
function
FUNCTION: Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons. {ECO:0000269|PubMed:10704386}.
uniprot
proteins
mass_dalton
37202
uniprot
proteins
post_translational_modification
PTM: Inducible phosphorylation of tyrosine residues in the cytoplasmic domain. {ECO:0000250}.
uniprot
proteins
protein_family
Ephrin family
uniprot
proteins
pubmed
10704386
uniprot
proteins
pubmed
11703926
uniprot
proteins
pubmed
11780069
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
27446912
uniprot
proteins
pubmed
30639848
uniprot
proteins
pubmed
7534404
uniprot
proteins
pubmed
7651410
uniprot
proteins
pubmed
8559144
uniprot
proteins
sequence_length
336
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P52799}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, adherens junction {ECO:0000269|PubMed:30639848}.
uniprot
proteins
transmembrane_region
TRANSMEM 233..253; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins