Sec61a1
entrez
80843
canonical
uniprot
P61621
canonical
ensembl
ENSRNOG00000013743
resolver
ensembl
ENSRNOG00055012068
resolver
ensembl
ENSRNOG00060026621
resolver
ensembl
ENSRNOG00065015545
resolver
ensp
ENSRNOP00000018455
resolver
ensp
ENSRNOP00055016533
resolver
ensp
ENSRNOP00060038531
resolver
ensp
ENSRNOP00065020348
resolver
enst
ENSRNOT00000018454
resolver
enst
ENSRNOT00055020532
resolver
enst
ENSRNOT00060046368
resolver
enst
ENSRNOT00065025862
resolver
genesymbol
Sec61a1
resolver
genesymbol_syn
Sec61a
resolver
uniprot
P38378
resolver
uniprot
P57726
resolver
uniprot
Q505I3
resolver
uniprot_entry
S61A1_RAT
resolver
uniprot_sec
P38378
resolver
uniprot_sec
P57726
resolver
uniprot_sec
Q505I3
resolver
amino_acid_sequence
MAIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMIITIGQSIVYVMTGMYGDPSEMGAGICLLITIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTVNTGRGMEFEGAIIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATIFVFAVVIYFQGFRVDLPIKSARYRGQYNTYPIKLFYTSNIPIILQSALVSNLYVISQMLSARFSGNLLVSLLGTWSDTSSGGPARAYPVGGLCYYLSPPESFGSVLEDPVHAVVYIVFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRETSMVHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQSEVGSMGALLF
uniprot
proteins
function
FUNCTION: Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins. The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex. The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER. Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis (By similarity). Plays a critical role in nephrogenesis, specifically at pronephros stage (By similarity). {ECO:0000250|UniProtKB:P61619, ECO:0000250|UniProtKB:P61620}.
uniprot
proteins
mass_dalton
52265
uniprot
proteins
protein_family
SecY/SEC61-alpha family
uniprot
proteins
pubmed
1423609
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
476
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P61619}; Multi-pass membrane protein {ECO:0000305}. Note=Localizes exclusively in granular structures in the endoplasmic reticulum (ER). {ECO:0000250|UniProtKB:P61619}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..53; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 77..96; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 118..138; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 145..165; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 173..193; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 241..261; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 289..309; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 355..375; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 421..441; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 446..462; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins