Ttyh3
entrez
78339
canonical
uniprot
Q6P5F7
canonical
ensembl
ENSMUSG00000036565
resolver
ensp
ENSMUSP00000037447
resolver
ensp
ENSMUSP00000142655
resolver
ensp
ENSMUSP00000298789
resolver
genesymbol
Ttyh3
resolver
genesymbol_syn
Kiaa1691
resolver
uniprot
Q69ZD3
resolver
uniprot
Q6PCX0
resolver
uniprot
Q8C789
resolver
uniprot_entry
TTYH3_MOUSE
resolver
uniprot_sec
Q69ZD3
resolver
uniprot_sec
Q6PCX0
resolver
uniprot_sec
Q8C789
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by (4-[(2-butyl-6,7-dichloro-2- cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]butanoic acid), genistein and PD98059 (MEK1 inhibitor). {ECO:0000269|PubMed:31138989}.
uniprot
proteins
amino_acid_sequence
MAGVSYAAPWWVSLLHRLPHFDLRWEATSSQFRPEDADYQQALLLLGATALACLALDLLFLLFYSFWLCCRRRKTDEHLDADCCCTAWCVIITTLVCSAGIAVGFYGNGETSDGIHRATYSLRHANRTVAGVQDRVWDTAAALNRTAEPNLQSLERQLAGRQEPLRAVQRLQTLLGTLLGYTAAIPFWRNPGVSLEVLAEQVDLYDWYRWLGYLGLLLLDVIICLLVLVGLIRSSKGILVGVCLLGVLALVISWGALGLELAVSVGSSDFCVDPDTFVTKMVEEHSVLSGDILQYYLACSPRATNPFQQKLSGSHKALVEMQDVVAELLRNVPREHPATKDPLLRVQEVLNGTEVNLQHLTALVDCRSLHLDYVQALTGFCYDGVEGLIYLALFSFVTALMFSSIVCSIPHTWQQKRGPDDDGEEETAPGPRQAHDSLYRVHMPSLYSCGSSYGSEASIPAAAHTVSNAPVTEYMSQNANFQNPRCENTPLIGRESPPPSYTSSMRAKYLATSQPRPDSSGSGH
uniprot
proteins
function
FUNCTION: Calcium-independent, swelling-dependent volume-regulated anion channel (VRAC-swell) which plays a pivotal role in the process of regulatory volume decrease (RVD) in the brain through the efflux of anions like chloride and organic osmolytes like glutamate (PubMed:31138989). Probable large-conductance Ca(2+)-activated chloride channel (By similarity). {ECO:0000250|UniProtKB:Q9C0H2, ECO:0000269|PubMed:31138989}.
uniprot
proteins
mass_dalton
57714
uniprot
proteins
mutagenesis
MUTAGEN 299; /note="C->A: Impairs homotetramerization."; /evidence="ECO:0000269|PubMed:36042377"; MUTAGEN 366; /note="C->A: Impairs homotetramerization."; /evidence="ECO:0000269|PubMed:36042377
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by NEDD4L. {ECO:0000250|UniProtKB:Q9C0H2}.; PTM: N-glycosylated. {ECO:0000269|PubMed:36042377}.
uniprot
proteins
protein_family
Tweety family
uniprot
proteins
pubmed
15010458
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
31138989
uniprot
proteins
pubmed
34824283
uniprot
proteins
pubmed
36042377
uniprot
proteins
sequence_length
524
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:36042377}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 43..63; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 87..107; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 212..232; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 237..257; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 387..407; /note="Helical; Name=5"; /evidence="ECO:0000255
uniprot
proteins