CHRM2
entrez
1129
canonical
uniprot
P08172
canonical
ensembl
ENSG00000181072
resolver
ensp
ENSP00000319984
resolver
ensp
ENSP00000384401
resolver
ensp
ENSP00000399745
resolver
ensp
ENSP00000415386
resolver
ensp
ENSP00000505686
resolver
ensp
ENSP00000573498
resolver
ensp
ENSP00000573499
resolver
ensp
ENSP00000573500
resolver
ensp
ENSP00000634776
resolver
ensp
ENSP00000634777
resolver
ensp
ENSP00000634778
resolver
enst
ENST00000320658
resolver
enst
ENST00000401861
resolver
enst
ENST00000445907
resolver
enst
ENST00000453373
resolver
enst
ENST00000680005
resolver
enst
ENST00000903439
resolver
enst
ENST00000903440
resolver
enst
ENST00000903441
resolver
enst
ENST00000964717
resolver
enst
ENST00000964718
resolver
enst
ENST00000964719
resolver
genesymbol
CHRM2
resolver
hgnc
HGNC:1951
resolver
uniprot
A4D1Q0
resolver
uniprot
Q4VBK6
resolver
uniprot
Q6SL56
resolver
uniprot
Q6SL59
resolver
uniprot
Q86SJ1
resolver
uniprot
Q9P1X9
resolver
uniprot_entry
A4D1Q0_HUMAN
resolver
uniprot_entry
ACM2_HUMAN
resolver
uniprot_entry
Q6SL56_HUMAN
resolver
uniprot_entry
Q6SL59_HUMAN
resolver
uniprot_entry
Q86SJ1_HUMAN
resolver
uniprot_sec
Q4VBK6
resolver
uniprot_sec
Q9P1X9
resolver
activity_regulation
ACTIVITY REGULATION: Activated by allosteric modulator LY2119620. {ECO:0000269|PubMed:36690613}.
uniprot
proteins
amino_acid_sequence
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRIVKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
uniprot
proteins
disease_involvement
DISEASE: Major depressive disorder (MDD) [MIM:608516]: A common psychiatric disorder. It is a complex trait characterized by one or more major depressive episodes without a history of manic, mixed, or hypomanic episodes. A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional symptoms must also be present including changes in appetite, weight, sleep, and psychomotor activity; decreased energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent thoughts of death or suicidal ideation, plans, or attempts. The episode must be accompanied by distress or impairment in social, occupational, or other important areas of functioning. {ECO:0000269|PubMed:15229186}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Muscarinic receptor for acetylcholine, a neurotransmitter found in the brain, neuromuscular junctions and the autonomic ganglia (PubMed:24256733, PubMed:3443095, PubMed:36690613). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:36690613). CHRM2 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G proteins and mediates signaling by inhibiting adenylate cyclase activity (PubMed:36690613). {ECO:0000269|PubMed:24256733, ECO:0000269|PubMed:3443095, ECO:0000269|PubMed:36690613}.
uniprot
proteins
mass_dalton
51715
uniprot
proteins
mutagenesis
MUTAGEN 58; /note="N->A: Nearly abolishes signaling via downstream effectors."; /evidence="ECO:0000269|PubMed:24256733"; MUTAGEN 103; /note="D->E: Reduced affinity for acetylcholine. Abolishes signaling via downstream effectors."; /evidence="ECO:0000269|PubMed:24256733"; MUTAGEN 206; /note="Y->F: Abolishes signaling via downstream effectors."; /evidence="ECO:0000269|PubMed:24256733"; MUTAGEN 307..310; /note="TVST->AVAA: Impaired interaction with ARRB1 and ARRB2."; /evidence="ECO:0000269|PubMed:38175886"; MUTAGEN 308; /note="V->VK: Impaired interaction with ARRB1 and ARRB2."; /evidence="ECO:0000269|PubMed:37209686"; MUTAGEN 340..343; /note="TNTT->ANAA: Does not affect interaction with ARRB1 and ARRB2."; /evidence="ECO:0000269|PubMed:38175886"; MUTAGEN 404; /note="N->Q: Reduced affinity for acetylcholine. Reduces signaling via downstream effectors."; /evidence="ECO:0000269|PubMed:24256733
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of the P-X-P-P motif promotes association with beta-arrestin (ARRB1 and/or ARRB2), leading to receptor desensitization and negative regulation of G protein-coupled receptor signaling. {ECO:0000269|PubMed:37209686, ECO:0000269|PubMed:38175886}.
uniprot
proteins
protein_family
CHRM2 sub-subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Muscarinic acetylcholine receptor subfamily
uniprot
proteins
pubmed
15014171
uniprot
proteins
pubmed
15229186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16548883
uniprot
proteins
pubmed
20976005
uniprot
proteins
pubmed
22278061
uniprot
proteins
pubmed
24256733
uniprot
proteins
pubmed
3037705
uniprot
proteins
pubmed
3443095
uniprot
proteins
pubmed
36690613
uniprot
proteins
pubmed
37209686
uniprot
proteins
pubmed
38175886
uniprot
proteins
pubmed
7822302
uniprot
proteins
sequence_length
466
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22278061, ECO:0000269|PubMed:24256733, ECO:0000269|PubMed:3443095}; Multi-pass membrane protein {ECO:0000269|PubMed:22278061, ECO:0000269|PubMed:24256733}. Postsynaptic cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Phosphorylation in response to agonist binding promotes receptor internalization. {ECO:0000250|UniProtKB:P06199}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..46; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:36690613, ECO:0007744|PDB:7T8X, ECO:0007744|PDB:7T90, ECO:0007744|PDB:7T94, ECO:0007744|PDB:7T96"; TRANSMEM 61..85; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:36690613, ECO:0007744|PDB:7T8X, ECO:0007744|PDB:7T90, ECO:0007744|PDB:7T94, ECO:0007744|PDB:7T96"; TRANSMEM 93..119; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:36690613, ECO:0007744|PDB:7T8X, ECO:0007744|PDB:7T90, ECO:0007744|PDB:7T94, ECO:0007744|PDB:7T96"; TRANSMEM 141..162; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:36690613, ECO:0007744|PDB:7T8X, ECO:0007744|PDB:7T90, ECO:0007744|PDB:7T94, ECO:0007744|PDB:7T96"; TRANSMEM 183..207; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:36690613, ECO:0007744|PDB:7T8X, ECO:0007744|PDB:7T90, ECO:0007744|PDB:7T94, ECO:0007744|PDB:7T96"; TRANSMEM 388..412; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:36690613, ECO:0007744|PDB:7T8X, ECO:0007744|PDB:7T90, ECO:0007744|PDB:7T94, ECO:0007744|PDB:7T96"; TRANSMEM 420..442; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:36690613, ECO:0007744|PDB:7T8X, ECO:0007744|PDB:7T90, ECO:0007744|PDB:7T94, ECO:0007744|PDB:7T96
uniprot
proteins