Qsox1
entrez
84491
canonical
uniprot
Q6IUU3
canonical
ensembl
ENSRNOG00000003649
resolver
ensp
ENSRNOP00000005052
resolver
ensp
ENSRNOP00000061072
resolver
genesymbol
Qsox1
resolver
genesymbol_syn
Qscn6
resolver
genesymbol_syn
Sox2
resolver
uniprot
Q8K4M2
resolver
uniprot
Q99J80
resolver
uniprot_entry
QSOX1_RAT
resolver
uniprot_sec
Q8K4M2
resolver
uniprot_sec
Q99J80
resolver
amino_acid_sequence
MRRCGRHSGPPSLLLLLLLLPPLLLSVPGAYAARLSVLYSSSDPLTLLDADTVRPAVLGSSSAWAVEFFASWCGHCIAFAPTWKELANDVKDWRPALNLAVLDCADETNSAVCREFNIAGFPTVRFFKAFSKNGTGTALPAAGANVQTLRMRLIDALESHRDTWPPACPPLEPAKLKDINEFFTRSKAEYLALIFEREDSYLGREVTLDLSQFHAVAVRRVLNSESDVVSKFAVTDFPSCYLLLRNGSVSRVPVLVESRPFYTSYLRGLPGLTREAPPTTAAPVTPDKIAPTVWKFADRSKIYMADLESALHYILRVEVGKFSVLEGQRLVALKKFVAVLAKYFPGQPLVQNFLHSINDWLQKQQKKKIPYSYFKAALDSRKENAVLAEKVNWIGCQGSEPHFRGFPCSLWVLFHFLTVQAHRYSEAHPQEPADGQEVLQAMRSYVQSFFGCRDCANHFEQMAAASMHQVKSPSNAVLWLWTSHNRVNARLSGALSEDPQFPKVQWPPRELCSACHNEVNGQVPLWDLGATLNFLKAHFSPANIVRDPPAPGPASRRGTQDPEASPNLVMDTLKLETGNSVLGHEQAASAASPGATALDVPAGKPEASGPQELNAGLSMGGASPGQGPPEHTEELLRDVQENAQGQQHLSKRDTEALLLPEVNHLQGPLAPRRGGHSPKQLASILEGEPEALAIQGRRQWLQVLGGGVSFLDISLCVGLYSVSFMGLLAMYTYFRARMRTPKGHVSYPTA
uniprot
proteins
ec_number
1.8.3.2
uniprot
proteins
function
FUNCTION: Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide (PubMed:11278790). Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration (By similarity). {ECO:0000250|UniProtKB:O00391, ECO:0000269|PubMed:11278790}.
uniprot
proteins
mass_dalton
82412
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. O-glycosylated on Thr and Ser residues. {ECO:0000250|UniProtKB:O00391}.
uniprot
proteins
protein_family
Quiescin-sulfhydryl oxidase (QSOX) family
uniprot
proteins
pubmed
11278790
uniprot
proteins
pubmed
12354420
uniprot
proteins
pubmed
16806532
uniprot
proteins
pubmed
24888638
uniprot
proteins
pubmed
26819240
uniprot
proteins
sequence_length
750
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Golgi apparatus membrane {ECO:0000250|UniProtKB:O00391}; Single-pass membrane protein {ECO:0000250|UniProtKB:O00391}. Secreted {ECO:0000250|UniProtKB:O00391}. Note=A small proportion is secreted, probably via a proteolytic cleavage that removes the membrane anchor. {ECO:0000250|UniProtKB:O00391}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000269|PubMed:11278790, ECO:0000269|PubMed:12354420}.
uniprot
proteins
transmembrane_region
TRANSMEM 710..730; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins