Slc28a3
entrez
114304
canonical
uniprot
Q9ERH8
canonical
ensembl
ENSMUSG00000021553
resolver
ensp
ENSMUSP00000022036
resolver
enst
ENSMUST00000022036
resolver
genesymbol
Slc28a3
resolver
genesymbol_syn
Cnt3
resolver
uniprot
Q3UM72
resolver
uniprot
Q8BWE2
resolver
uniprot
Q91VD7
resolver
uniprot_entry
S28A3_MOUSE
resolver
uniprot_sec
Q3UM72
resolver
uniprot_sec
Q8BWE2
resolver
uniprot_sec
Q91VD7
resolver
amino_acid_sequence
MSRADPGKNSEPSESKMSLELRPTAPSDLGRSNEAFQDEDLERQNTPGNSTVRNRVVQSGEQGHAKQDDRQITIEQEPLGNKEDPEDDSEDEHQKGFLERKYDTICEFCRKHRVVLRSTIWAVLLTGFLALVIAACAINFHRALPLFVITLVTIFFVIWDHLMAKYEQRIDDFLSPGRRLLDRHWFWLKWVVWSSLILAIILWLSLDTAKLGQQNLVSFGGLIMYLILLFLFSKHPTRVYWRPVFWGIGLQFLLGLLILRTRPGFVAFDWMGRQVQTFLGYTDTGARFVFGEKYTDHFFAFKILPIVVFFSTVMSMLYYLGLMQWIIRKVGWLMLVTMGSSPIESVVAAGNIFIGQTESPLLVQPYLPHVTKSELHTIMTAGFATIAGSVLGAYISFGVSSTHLLTASVMSAPAALAVAKLFWPETEKPKITLKSAMKMENGDSRNLLEAASQGASSSIPLVANIAANLIAFLALLSFVNSALSWFGSMFNYPELSFELICSYIFMPFSFMMGVDWQDSFMVAKLIGYKTFFNEFVAYDHLSKLINLRKAAGPKFVNGVQQYMSIRSETIATYALCGFANFGSLGIVIGGLTSIAPSRKRDIASGAMRALIAGTIACFMTACIAGILSDTPVDINCHHVLENGRVLSNTTEVVSCCQNLFNSTVAKGPNDVVPGGNFSLYALKSCCNLLKPPTLNCNWIPNKL
uniprot
proteins
function
FUNCTION: Sodium-dependent, pyrimidine- and purine-selective (PubMed:11032837). Involved in the homeostasis of endogenous nucleosides (PubMed:11032837). Exhibits the transport characteristics of the nucleoside transport system cib or N3 subtype (N3/cib) (with marked transport of both thymidine and inosine) (PubMed:11032837). Employs a 2:1 sodium/nucleoside ratio (PubMed:11032837). Also able to transport gemcitabine, 3'-azido-3'-deoxythymidine (AZT), ribavirin and 3-deazauridine (By similarity). {ECO:0000250|UniProtKB:Q9HAS3, ECO:0000269|PubMed:11032837}.
uniprot
proteins
mass_dalton
78310
uniprot
proteins
protein_family
Concentrative nucleoside transporter (CNT) (TC 2.A.41) family
uniprot
proteins
pubmed
11032837
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
703
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9HAS3}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 118..138; /note="Helical; Name=TM1"; /evidence="ECO:0000250|UniProtKB:Q9HAS3"; TRANSMEM 144..164; /note="Helical; Name=TM2"; /evidence="ECO:0000250|UniProtKB:Q9HAS3"; TRANSMEM 189..209; /note="Helical; Name=TM3"; /evidence="ECO:0000250|UniProtKB:Q9HAS3"; TRANSMEM 213..234; /note="Helical; Name=TM4"; /evidence="ECO:0000250|UniProtKB:Q9HAS3"; TRANSMEM 243..262; /note="Helical; Name=TM5"; /evidence="ECO:0000250|UniProtKB:Q9HAS3"; TRANSMEM 300..320; /note="Helical; Name=TM6"; /evidence="ECO:0000250|UniProtKB:Q9HAS3"; TRANSMEM 377..399; /note="Helical; Name=TM7"; /evidence="ECO:0000250|UniProtKB:Q9HAS3"; TRANSMEM 402..423; /note="Helical; Name=TM8"; /evidence="ECO:0000250|UniProtKB:Q9HAS3"; TRANSMEM 459..484; /note="Helical; Name=TM9"; /evidence="ECO:0000250|UniProtKB:Q9HAS3"; TRANSMEM 582..592; /note="Helical; Name=TM10"; /evidence="ECO:0000250|UniProtKB:Q9HAS3"; TRANSMEM 606..628; /note="Helical; Name=TM11"; /evidence="ECO:0000250|UniProtKB:Q9HAS3
uniprot
proteins