Aurkc
entrez
20871
canonical
uniprot
O88445
canonical
ensembl
ENSMUSG00000070837
resolver
ensp
ENSMUSP00000083426
resolver
ensp
ENSMUSP00000146450
resolver
ensp
ENSMUSP00000147207
resolver
ensp
ENSMUSP00000331077
resolver
enst
ENSMUST00000086248
resolver
enst
ENSMUST00000207711
resolver
enst
ENSMUST00000208049
resolver
genesymbol
Aurkc
resolver
genesymbol_syn
Aie1
resolver
genesymbol_syn
Aik3
resolver
genesymbol_syn
Airk3
resolver
genesymbol_syn
Ark3
resolver
genesymbol_syn
Stk13
resolver
uniprot
E9QL04
resolver
uniprot
Q497X5
resolver
uniprot
Q6P209
resolver
uniprot
Q9JLC2
resolver
uniprot_entry
AURKC_MOUSE
resolver
uniprot_entry
E9QL04_MOUSE
resolver
uniprot_entry
Q497X5_MOUSE
resolver
uniprot_sec
Q6P209
resolver
uniprot_sec
Q9JLC2
resolver
activity_regulation
ACTIVITY REGULATION: Okadaic acid, an inhibitor of protein phosphatase 1 (PP1), protein phosphatase 2A (PP2A) and protein phosphatase 5 (PP5), increases AURKC activity. AURKC is also stabilized through its interaction with INCENP, which also acts as an activator (By similarity). {ECO:0000250|UniProtKB:Q9UQB9}.
uniprot
proteins
amino_acid_sequence
MEPSTSTRKHFTINDFEIGRPLGRGKFGRVYLARLKENHFIVALKVLFKSEIEKEGLEHQLRREVEIQAHLQHRNILRLYNYFYDDTRIYLILEYAPGGELYKELQRHQKLDQQRTATIIQELSDALTYCHEKKVIHRDIKPENLLLGLNGEVKISDFGWSVHTPSLRRKTMCGTLDYLPPEMIAQKPYNEMVDLWCIGVLCYELLVGKPPFESSTSSETYRRIRQVDFKFPSSVPAGAQDLISKLLRYHPSERLSLAQVLKHPWVREHSRRVLPC
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Also plays a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'. {ECO:0000269|PubMed:11879579, ECO:0000269|PubMed:21613325}.
uniprot
proteins
mass_dalton
32358
uniprot
proteins
mutagenesis
MUTAGEN 171; /note="T->A: Impairs kinase activity, when associated with A-175."; /evidence="ECO:0000269|PubMed:11879579"; MUTAGEN 175; /note="T->A: Impairs kinase activity, when associated with A-171."; /evidence="ECO:0000269|PubMed:11879579
uniprot
proteins
protein_family
Aurora subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Ser/Thr protein kinase family
uniprot
proteins
pubmed
11098217
uniprot
proteins
pubmed
11879579
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21613325
uniprot
proteins
pubmed
9809744
uniprot
proteins
sequence_length
276
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Chromosome, centromere {ECO:0000250|UniProtKB:Q9UQB9}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9UQB9}. Note=Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis (By similarity). {ECO:0000250|UniProtKB:Q9UQB9}.
uniprot
proteins