BRME1
entrez
79173
canonical
uniprot
Q0VDD7
canonical
ensembl
ENSG00000132016
resolver
ensembl
ENSG00000288152
resolver
ensp
ENSP00000254336
resolver
ensp
ENSP00000465822
resolver
ensp
ENSP00000466723
resolver
ensp
ENSP00000500915
resolver
ensp
ENSP00000541236
resolver
ensp
ENSP00000541238
resolver
enst
ENST00000591586
resolver
enst
ENST00000673392
resolver
genesymbol
BRME1
resolver
genesymbol_syn
C19orf57
resolver
hgnc
HGNC:28153
resolver
uniprot
K7EMZ7
resolver
uniprot
Q13411
resolver
uniprot
Q8N825
resolver
uniprot
Q96D63
resolver
uniprot
Q9BU49
resolver
uniprot_entry
BRME1_HUMAN
resolver
uniprot_entry
K7EMZ7_HUMAN
resolver
uniprot_sec
Q13411
resolver
uniprot_sec
Q8N825
resolver
uniprot_sec
Q96D63
resolver
uniprot_sec
Q9BU49
resolver
amino_acid_sequence
MTKRKKLRTSGEGLCPPKPLKNPRLGDFYGDPQSSMLGCLHHPEEPEGKLGPVPSTQQHGEEPGKAVSSSPDEETGSPCRLLRQPEKEPAPLPPSQNSFGRFVPQFAKSRKTVTRKEEMKDEDRGSGAFSLETIAESSAQSPGCQLLVETLGVPLQEATELGDPTQADSARPEQSSQSPVQAVPGSGDSQPDDPPDRGTGLSASQRASQDHLSEQGADDSKPETDRVPGDGGQKEHLPSIDSEGEKPDRGAPQEGGAQRTAGAGLPGGPQEEGDGVPCTPASAPTSGPAPGLGPASWCLEPGSVAQGSPDPQQTPSRMGREGEGTHSSLGCSSLGMVVIADLSTDPTELEERALEVAGPDGQASAISPASPRRKAADGGHRRALPGCTSLTGETTGESGEAGQDGKPPGDVLVGPTASLALAPGSGESMMGAGDSGHASPDTGPCVNQKQEPGPAQEEAELGGQNLERDLEGFRVSPQASVVLEHREIADDPLQEPGAQQGIPDTTSELAGQRDHLPHSADQGTWADSLAVELDFLLDSQIQDALDASDFEAPPEQLFPSGNKPGPCWPGPSSHANGDPVAVAKAQPRTFVGIQASEASRMEDATNVVRGLIVELSNLNRLIMGTHRDLEAFKRLNYRKTKLGGKAPLPYPSKGPGNIPRGDPPWREL
uniprot
proteins
function
FUNCTION: Meiotic recombination factor component of recombination bridges involved in meiotic double-strand break repair. Modulates the localization of recombinases DMC1:RAD51 to meiotic double-strand break (DSB) sites through the interaction with and stabilization of the BRCA2:HSF2BP complex during meiotic recombination. Indispensable for the DSB repair, homologous synapsis, and crossover formation that are needed for progression past metaphase I, is essential for spermatogenesis and male fertility. {ECO:0000250|UniProtKB:Q6DIA7}.
uniprot
proteins
mass_dalton
69556
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
8228263
uniprot
proteins
sequence_length
668
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q6DIA7}. Note=During meiosis, recruited to chromosomes and localizes on recombination sites in a double-strand break-dependent manner. First appears on the chromosome axis at leptotene. Along with the progression of meiotic recombination, released from the axis to form bridge-like structures linking homolog axes before they are synapsed. Finally, located between synapsed homolog axes and on the synaptonemal complex (SC). {ECO:0000250|UniProtKB:Q6DIA7}.
uniprot
proteins