Tlr5
entrez
53791
canonical
uniprot
Q9JLF7
canonical
ensembl
ENSMUSG00000079164
resolver
ensp
ENSMUSP00000141318
resolver
ensp
ENSMUSP00000141458
resolver
ensp
ENSMUSP00000219879
resolver
ensp
ENSMUSP00000219880
resolver
ensp
ENSMUSP00000219881
resolver
enst
ENSMUST00000191820
resolver
enst
ENSMUST00000193687
resolver
genesymbol
Tlr5
resolver
uniprot
A0A0A6YVY4
resolver
uniprot
A0A0A6YW98
resolver
uniprot
Q05AH3
resolver
uniprot
Q8CB40
resolver
uniprot_entry
A0A0A6YVY4_MOUSE
resolver
uniprot_entry
A0A0A6YW98_MOUSE
resolver
uniprot_entry
Q05AH3_MOUSE
resolver
uniprot_entry
Q8CB40_MOUSE
resolver
uniprot_entry
TLR5_MOUSE
resolver
amino_acid_sequence
MACQLDLLIGVIFMASPVLVISPCSSDGRIAFFRGCNLTQIPWILNTTTERLLLSFNYISMVVATSFPLLERLQLLELGTQYANLTIGPGAFRNLPNLRILDLGQSQIEVLNRDAFQGLPHLLELRLFSCGLSSAVLSDGYFRNLYSLARLDLSGNQIHSLRLHSSFRELNSLSDVNFAFNQIFTICEDELEPLQGKTLSFFGLKLTKLFSRVSVGWETCRNPFRGVRLETLDLSENGWTVDITRNFSNIIQGSQISSLILKHHIMGPGFGFQNIRDPDQSTFASLARSSVLQLDLSHGFIFSLNPRLFGTLKDLKMLNLAFNKINKIGENAFYGLDSLQVLNLSYNLLGELYNSNFYGLPRVAYVDLQRNHIGIIQDQTFRLLKTLQTLDLRDNALKAIGFIPSIQMVLLGGNKLVHLPHIHFTANFLELSENRLENLSDLYFLLRVPQLQFLILNQNRLSSCKAAHTPSENPSLEQLFLTENMLQLAWETGLCWDVFQGLSRLQILYLSNNYLNFLPPGIFNDLVALRMLSLSANKLTVLSPGSLPANLEILDISRNQLLCPDPALFSSLRVLDITHNEFVCNCELSTFISWLNQTNVTLFGSPADVYCMYPNSLLGGSLYNISTEDCDEEEAMRSLKFSLFILCTVTLTLFLVITLVVIKFRGICFLCYKTIQKLVFKDKVWSLEPGAYRYDAYFCFSSKDFEWAQNALLKHLDAHYSSRNRLRLCFEERDFIPGENHISNIQAAVWGSRKTVCLVSRHFLKDGWCLEAFRYAQSRSLSDLKSILIVVVVGSLSQYQLMRHETIRGFLQKQQYLRWPEDLQDVGWFLDKLSGCILKEEKGKKRSSSIQLRTIATIS
uniprot
proteins
function
FUNCTION: Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response. Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota. Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response. Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life. {ECO:0000250|UniProtKB:O60602, ECO:0000269|PubMed:30089902}.
uniprot
proteins
mass_dalton
97627
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Tyr-799 upon flagellin binding; required for signaling. {ECO:0000250}.
uniprot
proteins
protein_family
Toll-like receptor family
uniprot
proteins
pubmed
10756091
uniprot
proteins
pubmed
30089902
uniprot
proteins
sequence_length
859
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 642..662; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins