RAD18
entrez
56852
canonical
uniprot
Q9NS91
canonical
ensembl
ENSG00000070950
resolver
ensp
ENSP00000264926
resolver
ensp
ENSP00000626648
resolver
enst
ENST00000264926
resolver
genesymbol
RAD18
resolver
genesymbol_syn
RNF73
resolver
hgnc
HGNC:18278
resolver
uniprot
Q58F55
resolver
uniprot
Q9NRT6
resolver
uniprot_entry
RAD18_HUMAN
resolver
uniprot_sec
Q58F55
resolver
uniprot_sec
Q9NRT6
resolver
amino_acid_sequence
MDSLAESRWPPGLAVMKTIDDLLRCGICFEYFNIAMIIPQCSHNYCSLCIRKFLSYKTQCPTCCVTVTEPDLKNNRILDELVKSLNFARNHLLQFALESPAKSPASSSSKNLAVKVYTPVASRQSLKQGSRLMDNFLIREMSGSTSELLIKENKSKFSPQKEASPAAKTKETRSVEEIAPDPSEAKRPEPPSTSTLKQVTKVDCPVCGVNIPESHINKHLDSCLSREEKKESLRSSVHKRKPLPKTVYNLLSDRDLKKKLKEHGLSIQGNKQQLIKRHQEFVHMYNAQCDALHPKSAAEIVREIENIEKTRMRLEASKLNESVMVFTKDQTEKEIDEIHSKYRKKHKSEFQLLVDQARKGYKKIAGMSQKTVTITKEDESTEKLSSVCMGQEDNMTSVTNHFSQSKLDSPEELEPDREEDSSSCIDIQEVLSSSESDSCNSSSSDIIRDLLEEEEAWEASHKNDLQDTEISPRQNRRTRAAESAEIEPRNKRNRN
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity. {ECO:0000269|PubMed:17108083, ECO:0000269|PubMed:21659603}.
uniprot
proteins
mass_dalton
56223
uniprot
proteins
mutagenesis
MUTAGEN 27; /note="I->A: Lower activity toward PCNA monoubiquitination."; /evidence="ECO:0000269|PubMed:21549715"; MUTAGEN 442; /note="S->A: Does not interact with SLF1 and is defective in restoring cell survival after DNA damage; when associated with A-444."; /evidence="ECO:0000269|PubMed:22036607, ECO:0000269|PubMed:25931565"; MUTAGEN 444; /note="S->A: Does not interact with SLF1 and is defective in restoring cell survival after DNA damage; when associated with A-442."; /evidence="ECO:0000269|PubMed:22036607, ECO:0000269|PubMed:25931565
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
RAD18 family
uniprot
proteins
pubmed
10884424
uniprot
proteins
pubmed
10908344
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15632077
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17108083
uniprot
proteins
pubmed
17130289
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18316726
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18719106
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21549715
uniprot
proteins
pubmed
21659603
uniprot
proteins
pubmed
22036607
uniprot
proteins
pubmed
22681887
uniprot
proteins
pubmed
22742833
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25931565
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
35849344
uniprot
proteins
sequence_length
495
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15632077, ECO:0000269|PubMed:22036607, ECO:0000269|PubMed:25931565}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:15632077}. Note=Associates with chromatin (PubMed:25931565). Colocalizes with SLF1 in the nucleus and to centrosomes (PubMed:15632077). Relocalizes with SLF1 to nuclear foci in response to DNA damage (PubMed:22036607). Accumulates with the SLF1-SLF2 and SMC5-SMC6 complexes at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565). {ECO:0000269|PubMed:15632077, ECO:0000269|PubMed:22036607, ECO:0000269|PubMed:25931565}.
uniprot
proteins