Ankrd2
entrez
56642
canonical
uniprot
Q9WV06
canonical
ensembl
ENSMUSG00000025172
resolver
ensp
ENSMUSP00000026172
resolver
ensp
ENSMUSP00000157671
resolver
ensp
ENSMUSP00000299540
resolver
enst
ENSMUST00000026172
resolver
enst
ENSMUST00000238137
resolver
genesymbol
Ankrd2
resolver
genesymbol_syn
Arpp
resolver
uniprot
A0A494B9J0
resolver
uniprot
B2RS77
resolver
uniprot
Q8QZX4
resolver
uniprot_entry
A0A494B9J0_MOUSE
resolver
uniprot_entry
ANKR2_MOUSE
resolver
uniprot_sec
B2RS77
resolver
uniprot_sec
Q8QZX4
resolver
amino_acid_sequence
MEGPEAVQRATELIEQRLAQEEETEKLRRSAPGKLSMDMLVLEEEKRLGVQSPALQKVKGQERVRKTSLDLRREIIDVGGIQNLIELRKKRKQKKRDALAAAQEPPPEPEEITGPVNEETFLKAAVEGKMKVIDKYLADGGSADTCDEFRRTALHRASLEGHMEILEKLLENGATVDFQDRLDCTAMHWACRGGHLEVVRLLQSRGADTNVRDKLLSTPLHVAVRTGHVEIVEHFLSLGLDINAKDREGDSALHDAVRLNRYKIIKLLLLHGADMMAKNLAGKTPTDLVQLWQADTRHALEHPEPESEQNGLERPGSGRETPQPIPAQ
uniprot
proteins
function
FUNCTION: Functions as a negative regulator of myocyte differentiation. May interact with both sarcoplasmic structural proteins and nuclear proteins to regulate gene expression during muscle development and in response to muscle stress. {ECO:0000269|PubMed:21737686, ECO:0000269|PubMed:23824195}.
uniprot
proteins
mass_dalton
36707
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-68 by PKB/AKT2 in response to oxidative stress induces translocation to the nucleus and negatively regulates myoblast differentiation. {ECO:0000250}.
uniprot
proteins
pubmed
10873377
uniprot
proteins
pubmed
11444853
uniprot
proteins
pubmed
12004005
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17926058
uniprot
proteins
pubmed
18302940
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21737686
uniprot
proteins
pubmed
23824195
uniprot
proteins
sequence_length
328
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, cytosol. Nucleus. Nucleus, PML body {ECO:0000250}. Note=In the sarcoplasm of differentiated striated muscle cells, where it is cytosolic and enriched in the I band. In nucleus and PML bodies of proliferating and undifferentiated myoblasts. Associates with the euchromatin in the nucleus of myocytes upon muscle stress.
uniprot
proteins