Mical3
entrez
194401
canonical
uniprot
Q8CJ19
canonical
ensembl
ENSMUSG00000051586
resolver
ensp
ENSMUSP00000076402
resolver
ensp
ENSMUSP00000144972
resolver
ensp
ENSMUSP00000158944
resolver
ensp
ENSMUSP00000293637
resolver
ensp
ENSMUSP00000293639
resolver
ensp
ENSMUSP00000293640
resolver
ensp
ENSMUSP00000293644
resolver
ensp
ENSMUSP00000293645
resolver
enst
ENSMUST00000204302
resolver
genesymbol
Mical3
resolver
genesymbol_syn
Kiaa0819
resolver
genesymbol_syn
Kiaa1364
resolver
uniprot
A0A0N4SV64
resolver
uniprot
A0ACM8Q6U8
resolver
uniprot
B2RR77
resolver
uniprot
Q3UGQ8
resolver
uniprot
Q3V160
resolver
uniprot
Q5CZW8
resolver
uniprot
Q69ZY5
resolver
uniprot
Q80TE8
resolver
uniprot
Q8BXB1
resolver
uniprot_entry
A0ACM8Q6U8_MOUSE
resolver
uniprot_entry
MICA3_MOUSE
resolver
uniprot_entry
Q5CZW8_MOUSE
resolver
uniprot_sec
A0A0N4SV64
resolver
uniprot_sec
B2RR77
resolver
uniprot_sec
Q3UGQ8
resolver
uniprot_sec
Q3V160
resolver
uniprot_sec
Q69ZY5
resolver
uniprot_sec
Q80TE8
resolver
uniprot_sec
Q8BXB1
resolver
amino_acid_sequence
MEERKQETTNQAHVLFDRFVQATTCKGTLRAFQELCDHLELKPKDYRSFYHKLKSKLNYWKAKALWAKLDKRGSHKDYKKGKACTNTKCLIIGAGPCGLRTAIDLSLLGAKVVVIEKRDAFSRNNVLHLWPFTIHDLRGLGAKKFYGKFCAGAIDHISIRQLQLILLKVALILGIEIHVNVEFQGLVQPPEDQENERIGWRALVHPKTHPVSEYEFEVIIGGDGRRNTLEGFRRKEFRGKLAIAITANFINRNTTAEAKVEEISGVAFIFNQKFFQELREATGIDLENIVYYKDDTHYFVMTAKKQSLLDKGVILHDYTDTELLLSRENVDQEALLNYAREAADFSTQQQLPSLDFAINHYGQPDVAMFDFTCMYASENAALVREQNGHQLLVALVGDSLLEPFWPMGTGIARGFLAAMDSAWMVRSWSLGTSPLEVLAERESIYRLLPQTTPENVSKNFSQYSIDPVTRYPNININFLRPSQVRHLYDSGETKDIHLEMENMVNPRTTPKLTRNESVARSSKLLGWCQRQTEGYSGVNVTDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQNVEKNNQLAFDIAEKELGISPIMTGKEMASVGEPDKLSMVMYLTQFYEMFKDSLSSSDTLDLNAEEKAVLIASTKSPISFLSKLGQTISRKRSPKDKKEKDSDGAGKRRKTSQSEEEEPPRSYKGERPTLVSTLTDRRMDAAVGNQNKVKYMATQLLAKFEENAPAQSTGVRRQGSIKKEFPQNLGGSDTCYFCQKRVYVMERLSAEGKFFHRSCFKCEYCATTLRLSAYAYDIEDGKFYCKPHYCYRLSGYAQRKRPAVAPLSGKEVKGALQDGPTADANGLASVAASSAERSPGTSMNGLEEPSIAKRLRGTPERIELENYRRSVRQVEELEEVPEETQAEHNLSSVLDKGTEEDVASSSSESEMEEEEEEDDEDDHLPTSDLGGVPWKEAVRIHALLKGRSEEELEASKNFEPEEEEEEEEYEEEDEEYEEEEEEESSEAGNKRLQQIITAADPLAIQADVHWTHIREREAEERMLPTSESSTSRAPLDEDDLEEDADSEPAETEGEAAEDGDPGDTGAELDDQHWSDDIPSDAEAEHRLQSQAKVKAELELRVSENEEEKPSDAPKQEERGTSQVSSPSQPPEKQVGVFSPARSPGTEEAKSPLATKVKSPEEPLFPTPLLLREKPKAEVPEEQKAVLSPIRSQPVALPEARSPTSPTSLQPESLLAPPTPPTPPPTQLPICSQPQPSSDASIPSPTKSPIRFQPVPAKTSTPLTPLPVKSQGDPKDRLSGPLAVEEVLKRSDLVEEFWMKSAEIRRSLGLTPVDRSKGSEPSLPSPASKPISLKSYSVDKSPQDEGLCLLKPPSVPKRLGLPKSAGDQPPLLTPKSPSDKELRSSQEERRDLSSSSGLGLHDSSSNMKTLGSQSFNTSDSTMLTPPSSPPPPPPPNEEPATLRRKPHQTFERREASIIPPPTPASFMRPPREPAQPPREEVRKSFVESVDEIPFADDVEDTYDDKTEDSSLQEKFFTPPSCWSRSEKLQAKENGRLPPLEQDVPPQKRGLPLVSAEAKELAEERMRAREKSVKSQALRDAMAKQLSRMQAMEMVSSRSHTAQSQGKELGSESTRHPSLRGTQEPTLKHEATSEEILSPPSDSGGPDGSVTSSEGSSGKSKKRSSLFSPRRNKKEKKTKGEARPPEKPSPGLPEDVVAKPKSLWKSVFSGYKKDKKKKSDEKSCSSTPSSGATVDSGQRRASPMVRAELQLRRQLSFSEDSDLSSDDILERSSQKSKREPRTYTEEELSAKLTRRVQKAARRQAKQEELKRLHRAQIIQRQLEQVEEKQRQLEERGVAVEKALRGEAGMGKKDDPKLMQEWFKLVQEKNAMVRYESELMIFARELELEDRQSRLQQELRERMAVEDHLKTEGELSEEKKILNEMLEVVEQRDSLVALLEEQRLREKEEDKDLEAAMLCKGFSLDWS
uniprot
proteins
ec_number
1.14.13.225
uniprot
proteins
function
FUNCTION: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). Seems to act as Rab effector protein and play a role in vesicle trafficking. Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process and implicates RAB8A associated with exocytotic vesicles. Required for cytokinesis. Contributes to stabilization and/or maturation of the intercellular bridge independently of its monooxygenase activity. Promotes recruitment of Rab8 and ERC1 to the intercellular bridge, and together these proteins are proposed to function in timely abscission. {ECO:0000250|UniProtKB:Q7RTP6}.
uniprot
proteins
mass_dalton
223721
uniprot
proteins
protein_family
Mical family
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1993
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q7RTP6}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q7RTP6}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q7RTP6}. Nucleus {ECO:0000250|UniProtKB:Q7RTP6}. Midbody {ECO:0000250|UniProtKB:Q7RTP6}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q7RTP6}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q7RTP6}. Note=Mainly localizes in the nucleus. {ECO:0000250|UniProtKB:Q7RTP6}.
uniprot
proteins