SNAP23
entrez
8773
canonical
uniprot
O00161
canonical
ensembl
ENSG00000092531
resolver
ensp
ENSP00000207062
resolver
ensp
ENSP00000249647
resolver
ensp
ENSP00000543796
resolver
ensp
ENSP00000543797
resolver
ensp
ENSP00000773545
resolver
genesymbol
SNAP23
resolver
hgnc
HGNC:11131
resolver
uniprot
A8K287
resolver
uniprot
O00162
resolver
uniprot
Q13602
resolver
uniprot
Q6IAE3
resolver
uniprot_entry
A8K287_HUMAN
resolver
uniprot_entry
SNP23_HUMAN
resolver
uniprot_sec
O00162
resolver
uniprot_sec
Q13602
resolver
uniprot_sec
Q6IAE3
resolver
amino_acid_sequence
MDNLSSEEIQQRAHQITDESLESTRRILGLAIESQDAGIKTITMLDEQKEQLNRIEEGLDQINKDMRETEKTLTELNKCCGLCVCPCNRTKNFESGKAYKTTWGDGGENSPCNVVSKQPGPVTNGQLQQPTTGAASGGYIKRITNDAREDEMEENLTQVGSILGNLKDMALNIGNEIDAQNPQIKRITDKADTNRDRIDIANARAKKLIDS
uniprot
proteins
function
FUNCTION: SNAREs (soluble N-ethylmaleimide-sensitive factor-attachment protein receptors) are essential proteins for intracellular membrane fusion. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four-helix bundle whose assembly releases energy that drives membrane fusion. The core SNARE complex typically consists of four alpha-helical domains, three from target membrane SNAREs (t-SNAREs) and one from a vesicle SNARE (v-SNARE) (PubMed:10036234, PubMed:11354632, PubMed:8663154, PubMed:9070898). SNAP23 is a t-SNARE (target-SNARE) that resides on target membrane and functions in the fusion of transport vesicles with the plasma membrane in immune cells (PubMed:30811271). In macrophages, regulates the stimulus-dependent vesicular transport of TLR4 from recycling endosomes to the plasma membrane by cooperating with STX11 and thereby plays a critical role in the recognition of microbial components and the induction of innate and adaptive immunity (PubMed:30811271). In skeletal muscle satellite cells, SNAP23 cooperates with its cognate SNAREs VAMP4 and STX11 to facilitate CD36 vesicular transport from endosomes to the plasma membrane, an essential step in muscle regeneration (By similarity). {ECO:0000250|UniProtKB:O09044, ECO:0000269|PubMed:10036234, ECO:0000269|PubMed:11354632, ECO:0000269|PubMed:30811271, ECO:0000269|PubMed:8663154, ECO:0000269|PubMed:9070898}.
uniprot
proteins
mass_dalton
23354
uniprot
proteins
protein_family
SNAP-25 family
uniprot
proteins
pubmed
10036234
uniprot
proteins
pubmed
11354632
uniprot
proteins
pubmed
12130530
uniprot
proteins
pubmed
12556468
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21044946
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24910990
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28882895
uniprot
proteins
pubmed
30811271
uniprot
proteins
pubmed
8663154
uniprot
proteins
pubmed
9070898
uniprot
proteins
sequence_length
211
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:30811271}; Lipid-anchor {ECO:0000269|PubMed:21044946}.
uniprot
proteins