P05505
uniprot
P05505
canonical
amino_acid_sequence
MTHQTHAYHMVNPSPWPLTGALSALLLTSGLVMWFHYNSTILLSLGLLTNILTMYQWWRDIIREGTYQGHHTPIVQKGLRYGMILFIVSEVFFFAGFFWAFYHSSLVPTHDLGGCWPPTGITPLNPLEVPLLNTSVLLASGVSITWAHHSLMEGNRNHMNQALLITILLGLYFTILQASEYFETSFSISDGIYGSTFFMATGFHGLHVIIGSTFLIVCLLRQLKFHFTSKHHFGFEAAAWYWHFVDVVWLFLYVSIYWWGS
uniprot
proteins
ec_number
7.1.1.9
uniprot
proteins
function
FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P00420}.
uniprot
proteins
mass_dalton
29871
uniprot
proteins
protein_family
Cytochrome c oxidase subunit 3 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
24185961
uniprot
proteins
pubmed
2504926
uniprot
proteins
pubmed
6091655
uniprot
proteins
pubmed
7601105
uniprot
proteins
sequence_length
261
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P00415}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P00415}.
uniprot
proteins
transmembrane_region
TRANSMEM 16..34; /note="Helical; Name=I"; /evidence="ECO:0000250|UniProtKB:P00415"; TRANSMEM 41..66; /note="Helical; Name=II"; /evidence="ECO:0000250|UniProtKB:P00415"; TRANSMEM 73..105; /note="Helical; Name=III"; /evidence="ECO:0000250|UniProtKB:P00415"; TRANSMEM 129..152; /note="Helical; Name=IV"; /evidence="ECO:0000250|UniProtKB:P00415"; TRANSMEM 156..183; /note="Helical; Name=V"; /evidence="ECO:0000250|UniProtKB:P00415"; TRANSMEM 191..223; /note="Helical; Name=VI"; /evidence="ECO:0000250|UniProtKB:P00415"; TRANSMEM 233..256; /note="Helical; Name=VII"; /evidence="ECO:0000250|UniProtKB:P00415
uniprot
proteins