Nme7
entrez
171566
canonical
uniprot
Q9QXL7
canonical
ensembl
ENSRNOG00000002898
resolver
ensembl
ENSRNOG00055017744
resolver
ensembl
ENSRNOG00060009526
resolver
ensp
ENSRNOP00000077126
resolver
ensp
ENSRNOP00055024111
resolver
ensp
ENSRNOP00060012599
resolver
enst
ENSRNOT00000117443
resolver
enst
ENSRNOT00055030019
resolver
enst
ENSRNOT00060016105
resolver
genesymbol
Nme7
resolver
uniprot
A6IDE2
resolver
uniprot
Q6PAG9
resolver
uniprot_entry
NDK7_RAT
resolver
uniprot_sec
A6IDE2
resolver
uniprot_sec
Q6PAG9
resolver
amino_acid_sequence
MKAGQQGRSCGLISPYLAPKNQSERFAFIAEWYDPNASLLRRYELLYYPVDGSVEMHDVKNRRTFLKRTKYEDLRVEDLFIGNKVNVFSRQLVLIDYGDQYTARQLGSRKEKTLALIKPDAVSKAGEIIEMINKSGFTITKLRMMTLSRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAICEWKRLLGPANSGIARSEAPGSVRALFGTDGIRNAAHGSDTFESAAREMELFFPSSGGCGPANTAKFTNCTCCIIKPHAISEGMLGKILIAIRDACFEISAIQMFNMDRANVEEFYEVYKGVVSEYNDMVTELYSGPCVAIEIQQSNPTKTFREFCGPSDPEIARHLRPETLRANFGKTKVQNAVHCTDLPEDGLLEVQYFFKILDN
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
ec_number
3.1.11.-
uniprot
proteins
function
FUNCTION: Possesses an intrinsic kinase activity. Phosphorylates GSK3B at 'Ser-9', leading to the activation of Wnt/beta-catenin signaling. Additionally, exhibits a 3'-5'-DNA exonuclease activity that removes single nucleotides from the 3' terminus of single-stranded DNA substrates and digests overhanging mismatched 3' termini from double-stranded DNA substrates, possibly participating in DNA nucleolytic processing. In vitro, does not seem to have nucleoside diphosphate kinase activity. Functional component of the gamma-tubulin ring complex, implicated in the regulation of its microtubule-nucleating activity in centrosomes, in a kinase activity-dependent manner. May maintain primary cilium assembly and ciliary microtubule stability. Part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, required for motile cilia beating. {ECO:0000250|UniProtKB:Q9Y5B8}.
uniprot
proteins
mass_dalton
44510
uniprot
proteins
protein_family
NDK family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20966424
uniprot
proteins
pubmed
33916973
uniprot
proteins
sequence_length
395
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9Y5B8}. Nucleus {ECO:0000250|UniProtKB:Q9Y5B8}. Cytoplasm {ECO:0000250|UniProtKB:Q9Y5B8}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9Y5B8}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q9Y5B8}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q5E9Y9}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9Y5B8}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9Y5B8}. Note=Localizes to centrosomes through its assembly into gamma-tubulin ring complex. The centrosomal content of NME7 varies during the cell cycle, being highest in mitosis and lowest in early G1 (By similarity). Localizes at the cilium basal body during cilium assembly (By similarity). {ECO:0000250|UniProtKB:Q9QXL8, ECO:0000250|UniProtKB:Q9Y5B8}.
uniprot
proteins