Nol3
entrez
78688
canonical
uniprot
Q9D1X0
canonical
ensembl
ENSMUSG00000014776
resolver
ensp
ENSMUSP00000014920
resolver
ensp
ENSMUSP00000307635
resolver
enst
ENSMUST00000014920
resolver
genesymbol
Nol3
resolver
genesymbol_syn
Arc
resolver
uniprot
Q53YU5
resolver
uniprot_entry
NOL3_MOUSE
resolver
uniprot_entry
Q53YU5_MOUSE
resolver
amino_acid_sequence
MGNVQERPSETIDRERKRLVETLQADSGLLLDALVARGVLTGPEYEALDALPDAERRVRRLLLLVQSKGEAACQELLRCAQQTVRMPDPAWDWQHVGPGYRNRSYDPSCPGHWTPEAPSSGTTCPELPRASEQEEVGGPEGSEALQPRTPEEPELEAEATEGDEPDLEQEMNPEQEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPDFQEEDESEDS
uniprot
proteins
function
FUNCTION: Apoptosis repressor that blocks multiple modes of cell death. Inhibits extrinsic apoptotic pathways through two different ways. Firstly by interacting with FAS and FADD upon FAS activation blocking death-inducing signaling complex (DISC) assembly (By similarity). Secondly by interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation (By similarity). Inhibits intrinsic apoptotic pathway in response to a wide range of stresses, through its interaction with BAX resulting in BAX inactivation, preventing mitochondrial dysfunction and release of pro-apoptotic factors (PubMed:16505176, PubMed:24312627). Inhibits calcium-mediated cell death by functioning as a cytosolic calcium buffer, dissociating its interaction with CASP8 and maintaining calcium homeostasis (By similarity). Negatively regulates oxidative stress-induced apoptosis by phosphorylation-dependent suppression of the mitochondria-mediated intrinsic pathway, by blocking CASP2 activation and BAX translocation (By similarity). Negatively regulates hypoxia-induced apoptosis in part by inhibiting the release of cytochrome c from mitochondria in a caspase-independent manner (By similarity). Also inhibits TNF-induced necrosis by preventing TNF-signaling pathway through TNFRSF1A interaction abrogating the recruitment of RIPK1 to complex I (PubMed:24440909). Finally through its role as apoptosis repressor, promotes vascular remodeling through inhibition of apoptosis and stimulation of proliferation, in response to hypoxia (PubMed:22082675). Inhibits too myoblast differentiation through caspase inhibition (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:O60936, ECO:0000250|UniProtKB:Q62881, ECO:0000269|PubMed:16505176, ECO:0000269|PubMed:22082675, ECO:0000269|PubMed:24312627, ECO:0000269|PubMed:24440909}.
uniprot
proteins
mass_dalton
24568
uniprot
proteins
mutagenesis
MUTAGEN 31; /note="L->F: Unable to inhibit TNF-induced necrosis; when associated with R-69. Unable to induce TNF nuclear translocation; when associated with R-69."; /evidence="ECO:0000269|PubMed:24440909"; MUTAGEN 69; /note="G->R: Unable to inhibit TNF-induced necrosis; when associated with F-31. Unable to induce TNF nuclear translocation; when associated with F-31."; /evidence="ECO:0000269|PubMed:24440909
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-149 is required for its antiapoptotic effect by blocking death-inducing signaling complex death-inducing signaling complex (DISC) activity through the control of interaction with CASP8. Phosphorylation at Thr-149 results in translocation to mitochondria and this translocation enables the binding to CASP8. Dephosphorylated at Thr-149 by calcineurin; doesn't inhibit the association between FADD and CASP8 and the consequent apoptosis. {ECO:0000250|UniProtKB:Q62881}.; PTM: Polyubiquitinated by MDM2; promoting proteasomal-dependent degradation in response to apoptotic stimuli. {ECO:0000250|UniProtKB:O60936, ECO:0000250|UniProtKB:Q62881}.
uniprot
proteins
pubmed
15383280
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16505176
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22082675
uniprot
proteins
pubmed
24312627
uniprot
proteins
pubmed
24440909
uniprot
proteins
sequence_length
220
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O60936, ECO:0000250|UniProtKB:Q62881}. Mitochondrion {ECO:0000250|UniProtKB:Q62881}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:Q62881}. Membrane {ECO:0000250|UniProtKB:O60936}; Lipid-anchor {ECO:0000250|UniProtKB:O60936}. Note=Phosphorylation at Thr-149 results in translocation to mitochondria. Colocalized with mitochondria in response to oxidative stress. {ECO:0000250|UniProtKB:Q62881}.
uniprot
proteins