Tomm22
entrez
223696
canonical
uniprot
Q9CPQ3
canonical
ensembl
ENSMUSG00000022427
resolver
ensp
ENSMUSP00000023062
resolver
enst
ENSMUST00000023062
resolver
genesymbol
Tomm22
resolver
genesymbol_syn
Tom22
resolver
uniprot
Q543M4
resolver
uniprot
Q9D8D3
resolver
uniprot_entry
TOM22_MOUSE
resolver
uniprot_sec
Q543M4
resolver
uniprot_sec
Q9D8D3
resolver
amino_acid_sequence
MAAAVAAAGAGEPLSPEELLPKAEAEKAEEELEEDDDDELDETLSERLWGLTEMFPERVRSAAGATFDLSLFVAQKMYRFSRAALWIGTTSFMILVLPVVFETEKLQMEQQQQLQQRQILLGPNTGLSGGMPGALPPLPGKM
uniprot
proteins
function
FUNCTION: Central receptor component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (By similarity). Together with the peripheral receptor TOMM20, functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore (By similarity). The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (By similarity). Required for the translocation across the mitochondrial outer membrane of cytochrome P450 monooxygenases (By similarity). {ECO:0000250|UniProtKB:Q75Q41, ECO:0000250|UniProtKB:Q9NS69}.
uniprot
proteins
mass_dalton
15537
uniprot
proteins
protein_family
Tom22 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
142
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q9NS69}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9NS69}.
uniprot
proteins
transmembrane_region
TRANSMEM 84..103; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q9NS69
uniprot
proteins