D3ZJ86
uniprot
D3ZJ86
canonical
amino_acid_sequence
MTSPKPWARSAGSCQTQRAVRTRKKECREEGESDTEKGPAASSASAQCSFPKRVSFFGWAGALDSSGGTTRAMDEEIVSEKQAEESHRQDSANLLIFILLLTLTILTIWLFKHRRARFLHETGLAMIYGLLVGLVLRYGIHVPSDVNNVTLSCEVQSSPTTLLVNVSGKFYEYTLKGEISSHELNNVQDNEMLRKVTFDPEVFFNILLPPIIFYAGYSLKRRHFFRNLGSILAYAFLGTAISCFVIGSIMYGCVTLMKVTGQLAGDFYFTDCLLFGAIVSATDPVTVLAIFHELQVDVELYALLFGESVLNDAVAIVLSSSIVAYQPAGDNSHTFDVTAMFKSIGIFLGIFSGSFAMGAATGVVTCHVTKFTKLREFQLLETGLFFLMSWSTFLLAEAWGFTGVVAVLFCGITQAHYTYNNLSTESQHRTKQLFELLNFLAENFIFSYMGLTLFTFQNHVFNPTFVVGAFIAIFLGRAANIYPLSLLLNLGRRSKIGSNFQHMMMFAGLRGAMAFALAIRDTATYARQMMFSTTLLIVFFTVWVFGGGTTAMLSCLHIRVGVDSDQEHLGVPDNERRTTKAESAWLFRMWYNFDHNYLKPLLTHSGPPLTTTLPACCGPIARCLTSPQAYENQEQLKDDDSDLILNDGDISLTYGDSTVNTESATASAPRRFMGTSTEDALDRELTFGDHELVIRGTRLVLPMDDSEPALNSLDDTRHSPA
uniprot
proteins
function
FUNCTION: Endosomal Na(+), K(+)/H(+) antiporter. Mediates the electroneutral exchange of endosomal luminal H(+) for a cytosolic Na(+) or K(+). By facilitating proton efflux, SLC9A6 counteracts the acidity generated by vacuolar (V)-ATPase, thereby limiting luminal acidification. Responsible for alkalizing and maintaining the endosomal pH, and consequently in, e.g., endosome maturation and trafficking of recycling endosomal cargo (By similarity). Plays a critical role during neurodevelopment by regulating synaptic development and plasticity (By similarity). Implicated in the maintenance of cell polarity in a manner that is dependent on its ability to modulate intravesicular pH (By similarity). Regulates intracellular pH in some specialized cells, osteoclasts and stereocilia where this transporter localizes to the plasma membrane (By similarity). {ECO:0000250|UniProtKB:A1L3P4, ECO:0000250|UniProtKB:Q92581}.
uniprot
proteins
mass_dalton
79894
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated (in vitro). {ECO:0000250|UniProtKB:Q92581}.; PTM: Glycosylated. {ECO:0000250|UniProtKB:Q92581}.
uniprot
proteins
protein_family
Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
34928329
uniprot
proteins
sequence_length
721
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endosome membrane {ECO:0000250|UniProtKB:Q92581}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q92581}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:Q92581}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q92581}. Late endosome membrane {ECO:0000250|UniProtKB:A1L3P4}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q92581}; Multi-pass membrane protein {ECO:0000255}. Note=Present predominantly in the recycling compartments including early and recycling endosomes, but undergoes plasma membrane localization during vesicular recycling, which is enhanced upon certain stimuli, such as hypoxia (By similarity). Has a major plasmalemmal distribution in a few specialized cells, such as in vestibular hair bundles and osteoblasts (By similarity). {ECO:0000250|UniProtKB:A1L3P4, ECO:0000250|UniProtKB:Q92581}.
uniprot
proteins
transmembrane_region
TRANSMEM 91..111; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 123..143; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 196..216; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 231..251; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 272..292; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 298..318; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 344..364; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 388..412; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 434..454; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 456..476; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 499..519; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 535..555; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins