Chmp6
entrez
208092
canonical
uniprot
P0C0A3
canonical
ensembl
ENSMUSG00000025371
resolver
ensp
ENSMUSP00000026434
resolver
enst
ENSMUST00000026434
resolver
genesymbol
Chmp6
resolver
uniprot
B1AZ39
resolver
uniprot_entry
B1AZ39_MOUSE
resolver
uniprot_entry
CHMP6_MOUSE
resolver
amino_acid_sequence
MGNLFGRKKQSRVTEQDRAILQLKQQRDKLRQYQKRVTQQLERERALARQLLRDGRKERAKLLLKKKRYREQLLDRTENQISSLEAMVQSIEFTQIEMKVMEGLQVGNECLNKMHQVMSIEEVERILDETQEAVEYQRQIDELLAGNFTQEDEDAILEELNAITQEQMELPEVPSEPLPDRNPEAPAKARSRQAELVAAS
uniprot
proteins
function
FUNCTION: Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. In the ESCRT-III complex, it probably serves as an acceptor for the ESCRT-II complex on endosomal membranes (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
23416
uniprot
proteins
post_translational_modification
PTM: ISGylated in a CHMP5-dependent manner. Isgylation weakens its interaction with VPS4A (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
SNF7 family
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
200
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250}. Endosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Late endosome membrane {ECO:0000250}. Membrane {ECO:0000250|UniProtKB:Q96FZ7}; Lipid-anchor {ECO:0000250|UniProtKB:Q96FZ7}. Note=Localizes to endosomal membranes. {ECO:0000250}.
uniprot
proteins