PTP4A3
entrez
11156
canonical
uniprot
O75365
canonical
ensembl
ENSG00000184489
resolver
ensembl
ENSG00000275575
resolver
ensembl
ENSG00000291470
resolver
ensp
ENSP00000331730
resolver
ensp
ENSP00000332274
resolver
ensp
ENSP00000428758
resolver
ensp
ENSP00000428976
resolver
ensp
ENSP00000505068
resolver
ensp
ENSP00000506615
resolver
ensp
ENSP00000573134
resolver
ensp
ENSP00000573135
resolver
ensp
ENSP00000573138
resolver
ensp
ENSP00000573142
resolver
ensp
ENSP00000573145
resolver
ensp
ENSP00000573146
resolver
ensp
ENSP00000573147
resolver
ensp
ENSP00000573149
resolver
ensp
ENSP00000573152
resolver
ensp
ENSP00000573153
resolver
ensp
ENSP00000573159
resolver
ensp
ENSP00000586257
resolver
ensp
ENSP00000625590
resolver
ensp
ENSP00000625593
resolver
ensp
ENSP00000625595
resolver
ensp
ENSP00000625596
resolver
ensp
ENSP00000625601
resolver
ensp
ENSP00000625603
resolver
ensp
ENSP00000625604
resolver
genesymbol
PTP4A3
resolver
genesymbol_syn
PRL3
resolver
hgnc
HGNC:9636
resolver
uniprot
Q8IVN5
resolver
uniprot
Q99849
resolver
uniprot
Q9BTW5
resolver
uniprot_entry
TP4A3_HUMAN
resolver
uniprot_sec
Q8IVN5
resolver
uniprot_sec
Q99849
resolver
uniprot_sec
Q9BTW5
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by sodium orthovanadate and peroxovanadium compounds, and by pentamidine. {ECO:0000269|PubMed:11355880, ECO:0000269|PubMed:12516958}.
uniprot
proteins
amino_acid_sequence
MARMNRPAPVEVSYKHMRFLITHNPTNATLSTFIEDLKKYGATTVVRVCEVTYDKTPLEKDGITVVDWPFDDGAPPPGKVVEDWLSLVKAKFCEAPGSCVAVHCVAGLGRAPVLVALALIESGMKYEDAIQFIRQKRRGAINSKQLTYLEKYRPKQRLRFKDPHTHKTRCCVM
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II. {ECO:0000269|PubMed:11355880, ECO:0000269|PubMed:12782572}.
uniprot
proteins
mass_dalton
19535
uniprot
proteins
mutagenesis
MUTAGEN 49; /note="C->A: No effect on enzymatic activity."; /evidence="ECO:0000269|PubMed:14704153"; MUTAGEN 71; /note="D->A: No effect on enzymatic activity."; /evidence="ECO:0000269|PubMed:14704153"; MUTAGEN 72; /note="D->A: Abolishes enzymatic activity."; /evidence="ECO:0000269|PubMed:14704153"; MUTAGEN 104; /note="C->A,S: 95% loss of enzymatic activity."; /evidence="ECO:0000269|PubMed:11355880, ECO:0000269|PubMed:12782572"; MUTAGEN 104; /note="C->S: Reduces migration-promoting activity."; /evidence="ECO:0000269|PubMed:11355880, ECO:0000269|PubMed:12782572"; MUTAGEN 111; /note="A->S: Enhances catalytic activity."; /evidence="ECO:0000269|PubMed:14704153
uniprot
proteins
post_translational_modification
PTM: Farnesylated. Farnesylation is required for membrane targeting (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
11355880
uniprot
proteins
pubmed
11598267
uniprot
proteins
pubmed
12235145
uniprot
proteins
pubmed
12516958
uniprot
proteins
pubmed
12782572
uniprot
proteins
pubmed
14704153
uniprot
proteins
pubmed
15135076
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9633825
uniprot
proteins
sequence_length
173
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12782572}. Early endosome {ECO:0000269|PubMed:12782572}.
uniprot
proteins