Pja2
entrez
224938
canonical
uniprot
Q80U04
canonical
ensembl
ENSMUSG00000024083
resolver
ensp
ENSMUSP00000133730
resolver
ensp
ENSMUSP00000134380
resolver
genesymbol
Pja2
resolver
genesymbol_syn
Kiaa0438
resolver
genesymbol_syn
Rnf131
resolver
uniprot
Q3TH95
resolver
uniprot
Q810E3
resolver
uniprot
Q91W46
resolver
uniprot
Q99KC0
resolver
uniprot_entry
PJA2_MOUSE
resolver
uniprot_sec
Q3TH95
resolver
uniprot_sec
Q810E3
resolver
uniprot_sec
Q91W46
resolver
uniprot_sec
Q99KC0
resolver
amino_acid_sequence
MSQYTEKEPSVMDQESSKAAWPKPAGGYQTITGRRYGRRHAYVSFKPCMTRHERSLGRAGDDYEVLELDDVPKENTSGSSSLDQVHPALPNEPTVEKSETEISTCGPALNQSTESSPSIATVCHSEEVRETLESNTNLHNRTETEHTPAVCNVSSVQNGIMLVHTDSYDPDSKHDENGSLQLGAEAVEGGRHQKGLGRAVFELENGEAEIYADLSPSVPSLNGEISEAFEELDSAPLEKSSTADAELVHQNGQEFQRSSEDGVVRKRRQDDTDQGRQTENSTEDADCAPGHVEQNTSDRANHHGSSPEQVVRPKVRKVISSSQVDQEIGFNRHEAKQRSVQRWREALEVEECSSDDPIIKCDDYDGDHDCMFLTPTYSRVTQRETERNRVTSENGATASGRQESRDNAFWNACGEYYQLFDKDEDSSECSDGEWSASLPHRFSGTEKDQSSSDDSWETLPGKDENDPELQSDSSGPEEENQELSLQEGEQTSLEEGEIPWLQYNEVNESSSDEGNEPANEFAQPEAFMLDGNNNLEDDSSVSEDLDVDWSLFDGFADGLGVAEAISYVDPQFLTYMALEERLAQAMETALAHLESLAVDVEVANPPASKESIDGLPETLVLEDHTAIGQEQCCPICCSEYIKDDIATELPCHHFFHKPCVSIWLQKSGTCPVCRRHFPPAVIDASAAASSDPDPDASPANDNAEEAP
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype. Plays a role in ciliogenesis by ubiquitinating OFD1. {ECO:0000250|UniProtKB:O43164}.
uniprot
proteins
mass_dalton
77958
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:O43164}.
uniprot
proteins
pubmed
12036302
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
707
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O43164}. Cell membrane {ECO:0000250|UniProtKB:O43164}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O43164}; Peripheral membrane protein {ECO:0000250|UniProtKB:O43164}. Golgi apparatus membrane {ECO:0000250|UniProtKB:O43164}; Peripheral membrane protein {ECO:0000250|UniProtKB:O43164}. Synapse {ECO:0000250|UniProtKB:Q63364}. Postsynaptic density {ECO:0000250|UniProtKB:Q63364}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:O43164}. Note=Localizes at the cytoplasmic side of endoplasmic reticulum and Golgi apparatus (By similarity). Expressed in the postsynaptic density region of synapses (By similarity). Colocalizes with PRKAR2A and PRKAR2B in the cytoplasm and the cell membrane (By similarity). {ECO:0000250|UniProtKB:O43164, ECO:0000250|UniProtKB:Q63364}.
uniprot
proteins