PACSIN1
entrez
29993
canonical
uniprot
Q9BY11
canonical
ensembl
ENSG00000124507
resolver
ensp
ENSP00000244458
resolver
ensp
ENSP00000439639
resolver
ensp
ENSP00000484060
resolver
ensp
ENSP00000635198
resolver
enst
ENST00000244458
resolver
enst
ENST00000538621
resolver
enst
ENST00000620693
resolver
enst
ENST00000965139
resolver
genesymbol
PACSIN1
resolver
genesymbol_syn
KIAA1379
resolver
hgnc
HGNC:8570
resolver
uniprot
Q5TZC3
resolver
uniprot
Q9P2G8
resolver
uniprot_entry
PACN1_HUMAN
resolver
uniprot_entry
Q5TZC3_HUMAN
resolver
uniprot_sec
Q9P2G8
resolver
amino_acid_sequence
MSSSYDEASLAPEETTDSFWEVGNYKRTVKRIDDGHRLCNDLMNCVQERAKIEKAYGQQLTDWAKRWRQLIEKGPQYGSLERAWGAIMTEADKVSELHQEVKNNLLNEDLEKVKNWQKDAYHKQIMGGFKETKEAEDGFRKAQKPWAKKMKELEAAKKAYHLACKEEKLAMTREMNSKTEQSVTPEQQKKLQDKVDKCKQDVQKTQEKYEKVLEDVGKTTPQYMENMEQVFEQCQQFEEKRLVFLKEVLLDIKRHLNLAENSSYIHVYRELEQAIRGADAQEDLRWFRSTSGPGMPMNWPQFEEWNPDLPHTTTKKEKQPKKAEGVALTNATGAVESTSQAGDRGSVSSYDRGQPYATEWSDDESGNPFGGSETNGGANPFEDDSKGVRVRALYDYDGQEQDELSFKAGDELTKLGEEDEQGWCRGRLDSGQLGLYPANYVEAI
uniprot
proteins
function
FUNCTION: Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission (By similarity). Binds to membranes via its F-BAR domain and mediates membrane tubulation. {ECO:0000250, ECO:0000269|PubMed:19549836, ECO:0000269|PubMed:22573331, ECO:0000269|PubMed:23236520}.
uniprot
proteins
mass_dalton
50966
uniprot
proteins
mutagenesis
MUTAGEN 125; /note="I->E: Reduces membrane-binding. Abolishes membrane tubulation."; /evidence="ECO:0000269|PubMed:19549836"; MUTAGEN 126; /note="M->E: Reduces membrane-binding. Abolishes membrane tubulation."; /evidence="ECO:0000269|PubMed:19549836
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC). {ECO:0000305}.
uniprot
proteins
protein_family
PACSIN family
uniprot
proteins
pubmed
10718198
uniprot
proteins
pubmed
11179684
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19549836
uniprot
proteins
pubmed
22573331
uniprot
proteins
pubmed
23236520
uniprot
proteins
sequence_length
444
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell projection {ECO:0000250}. Synapse, synaptosome {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Synapse {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Colocalizes with MAPT in axons. In primary neuronal cultures, present at a high level in presynaptic nerve terminals and in the cell body. Colocalizes with DNM1 at vesicular structures in the cell body and neurites (By similarity). Associates with membranes via its F-BAR domain. {ECO:0000250}.
uniprot
proteins