PA2G4
entrez
5036
canonical
uniprot
Q9UQ80
canonical
ensembl
ENSG00000170515
resolver
ensp
ENSP00000302886
resolver
genesymbol
PA2G4
resolver
genesymbol_syn
EBP1
resolver
hgnc
HGNC:8550
resolver
uniprot
O43846
resolver
uniprot
Q9UM59
resolver
uniprot_entry
PA2G4_HUMAN
resolver
uniprot_sec
O43846
resolver
uniprot_sec
Q9UM59
resolver
amino_acid_sequence
MSGEDEQQEQTIAEDLVVTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMIMEETGKIFKKEKEMKKGIAFPTSISVNNCVCHFSPLKSDQDYILKEGDLVKIDLGVHVDGFIANVAHTFVVDVAQGTQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWNKVAHSFNCTPIEGMLSHQLKQHVIDGEKTIIQNPTDQQKKDHEKAEFEVHEVYAVDVLVSSGEGKAKDAGQRTTIYKRDPSKQYGLKMKTSRAFFSEVERRFDAMPFTLRAFEDEKKARMGVVECAKHELLQPFNVLYEKEGEFVAQFKFTVLLMPNGPMRITSGPFEPDLYKSEMEVQDAELKALLQSSASRKTQKKKKKKASKTAENATSGETLEENEAGD
uniprot
proteins
function
FUNCTION: May play a role in a ERBB3-regulated signal transduction pathway. Seems be involved in growth regulation. Acts a corepressor of the androgen receptor (AR) and is regulated by the ERBB3 ligand neuregulin-1/heregulin (HRG). Inhibits transcription of some E2F1-regulated promoters, probably by recruiting histone acetylase (HAT) activity. Binds RNA. Associates with 28S, 18S and 5.8S mature rRNAs, several rRNA precursors and probably U3 small nucleolar RNA. May be involved in regulation of intermediate and late steps of rRNA processing. May be involved in ribosome assembly. Mediates cap-independent translation of specific viral IRESs (internal ribosomal entry site) (By similarity). Regulates cell proliferation, differentiation, and survival. Isoform 1 suppresses apoptosis whereas isoform 2 promotes cell differentiation (By similarity). {ECO:0000250|UniProtKB:P50580, ECO:0000250|UniProtKB:Q6AYD3, ECO:0000269|PubMed:11268000, ECO:0000269|PubMed:12682367, ECO:0000269|PubMed:15064750, ECO:0000269|PubMed:15583694, ECO:0000269|PubMed:16832058}.
uniprot
proteins
mass_dalton
43787
uniprot
proteins
mutagenesis
MUTAGEN 20..22; /note="KYK->AYA: Loss of nucleolar localization."; /evidence="ECO:0000269|PubMed:15064750"; MUTAGEN 361; /note="S->A: Loss of phosphorylation and interaction with ERBB3 and HUWE1."; /evidence="ECO:0000269|PubMed:16832058"; MUTAGEN 361; /note="S->D: No effect on phosphorylation and loss of nucleolar localization."; /evidence="ECO:0000269|PubMed:16832058"; MUTAGEN 363; /note="S->A: No effect on in vitro phosphorylation by PKC."; /evidence="ECO:0000269|PubMed:11325528"; MUTAGEN 364..365; /note="RK->AA: Only partial nucleolar localization."; /evidence="ECO:0000269|PubMed:15064750"; MUTAGEN 366; /note="T->A: Decreases in vitro phosphorylation by PKC."; /evidence="ECO:0000269|PubMed:11325528
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine and threonine residues. Phosphorylation is enhanced by HRG treatment. Basal phosphorylation is PKC-dependent and HRG-induced phosphorylation is predominantly PKC-independent. Phosphorylation at Ser-361 by PKC/PRKCD regulates its nucleolar localization. {ECO:0000269|PubMed:11325528, ECO:0000269|PubMed:16832058, ECO:0000269|PubMed:19037095}.; PTM: In cancer cells, isoform 2 is polyubiquitinated leading to its proteasomal degradation and phosphorylation by PKC/PRKCD enhances polyubiquitination. {ECO:0000269|PubMed:19037095}.
uniprot
proteins
protein_family
Peptidase M24 family
uniprot
proteins
pubmed
10682683
uniprot
proteins
pubmed
11268000
uniprot
proteins
pubmed
11325528
uniprot
proteins
pubmed
12429849
uniprot
proteins
pubmed
12682367
uniprot
proteins
pubmed
15064750
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15583694
uniprot
proteins
pubmed
16832058
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17765895
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19037095
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27346687
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
9345902
uniprot
proteins
sequence_length
394
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:16832058, ECO:0000269|PubMed:19037095}. Nucleus, nucleolus {ECO:0000269|PubMed:16832058, ECO:0000269|PubMed:19037095}. Note=Translocates to the nucleus upon treatment with HRG. Phosphorylation at Ser-361 by PKC/PRKCD regulates its nucleolar localization. {ECO:0000269|PubMed:16832058}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:16832058, ECO:0000269|PubMed:19037095}.
uniprot
proteins