Lgals8
entrez
56048
canonical
uniprot
Q9JL15
canonical
ensembl
ENSMUSG00000057554
resolver
ensp
ENSMUSP00000097408
resolver
ensp
ENSMUSP00000097409
resolver
ensp
ENSMUSP00000114200
resolver
ensp
ENSMUSP00000115094
resolver
ensp
ENSMUSP00000118925
resolver
ensp
ENSMUSP00000120210
resolver
ensp
ENSMUSP00000270435
resolver
ensp
ENSMUSP00000270438
resolver
ensp
ENSMUSP00000270443
resolver
ensp
ENSMUSP00000270445
resolver
ensp
ENSMUSP00000270463
resolver
enst
ENSMUST00000099820
resolver
enst
ENSMUST00000099821
resolver
enst
ENSMUST00000124888
resolver
enst
ENSMUST00000135166
resolver
enst
ENSMUST00000143693
resolver
enst
ENSMUST00000144283
resolver
genesymbol
Lgals8
resolver
uniprot
A8DIL0
resolver
uniprot
F6W8N5
resolver
uniprot
F6ZJ73
resolver
uniprot
Q542M5
resolver
uniprot
Q8C6H0
resolver
uniprot_entry
A8DIL0_MOUSE
resolver
uniprot_entry
F6W8N5_MOUSE
resolver
uniprot_entry
F6ZJ73_MOUSE
resolver
uniprot_entry
LEG8_MOUSE
resolver
uniprot_entry
Q542M5_MOUSE
resolver
uniprot_entry
Q8C6H0_MOUSE
resolver
amino_acid_sequence
MLSLNNLQNIIYNPIIPYVGTITEQLKPGSLIVIRGHVPKDSERFQVDFQLGNSLKPRADVAFHFNPRFKRSSCIVCNTLTQEKWGWEEITYDMPFRKEKSFEIVFMVLKNKFQVAVNGRHVLLYAHRISPEQIDTVGIYGKVNIHSIGFRFSSDLQSMETSALGLTQINRENIQKPGKLQLSLPFEARLNASMGPGRTVVIKGEVNTNARSFNVDLVAGKTRDIALHLNPRLNVKAFVRNSFLQDAWGEEERNITCFPFSSGMYFEMIIYCDVREFKVAINGVHSLEYKHRFKDLSSIDTLSVDGDIRLLDVRSW
uniprot
proteins
function
FUNCTION: Beta-galactoside-binding lectin that acts as a sensor of membrane damage caused by infection and restricts the proliferation of infecting pathogens by targeting them for autophagy. Detects membrane rupture by binding beta-galactoside ligands located on the lumenal side of the endosome membrane; these ligands becoming exposed to the cytoplasm following rupture. Restricts infection by initiating autophagy via interaction with CALCOCO2/NDP52. Required to restrict infection of bacterial invasion such as S.typhimurium. Also required to restrict infection of Picornaviridae viruses. Has a marked preference for 3'-O-sialylated and 3'-O-sulfated glycans. {ECO:0000250|UniProtKB:O00214}.
uniprot
proteins
mass_dalton
36162
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
316
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000250|UniProtKB:O00214}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:O00214}.
uniprot
proteins