Nrl
entrez
18185
canonical
uniprot
P54846
canonical
ensembl
ENSMUSG00000040632
resolver
ensp
ENSMUSP00000054457
resolver
ensp
ENSMUSP00000107035
resolver
ensp
ENSMUSP00000136445
resolver
ensp
ENSMUSP00000153933
resolver
enst
ENSMUST00000062232
resolver
enst
ENSMUST00000111404
resolver
enst
ENSMUST00000178694
resolver
genesymbol
Nrl
resolver
uniprot
Q543Y0
resolver
uniprot
Q8C8Y1
resolver
uniprot_entry
NRL_MOUSE
resolver
uniprot_entry
Q543Y0_MOUSE
resolver
uniprot_entry
Q8C8Y1_MOUSE
resolver
amino_acid_sequence
MAFPPSPLAMEYVNDFDLMKFEIKREPSEGRSGVPTASLGSTPYSSVPPSPTFSEPGMVGGGEAPRPGLEELYWLATLQQQLGSDEVLGLSPDEAVELLQNQGPVSMEGPLGYYSGSPGETGAQHVQLPERFSDAALVSMSVRELNRQLRGCGRDEALRLKQRRRTLKNRGYAQACRSKRLQQRRGLEAERARLAAQLDALRAEVARLARERDLYKARCDRLTSGGPGSDDHTHLFL
uniprot
proteins
function
FUNCTION: Acts as a transcriptional activator which regulates the expression of several rod-specific genes, including RHO and PDE6B. Also functions as a transcriptional coactivator, stimulating transcription mediated by the transcription factor CRX and NR2E3. Binds to the rhodopsin promoter in a sequence-specific manner. {ECO:0000250|UniProtKB:P54845}.
uniprot
proteins
mass_dalton
26083
uniprot
proteins
post_translational_modification
PTM: Disumoylated at Lys-20. Sumoylation modulates the transcriptional activity of NRL on RHO and NR2E3 promoters, and is required for normal rod differentiation. {ECO:0000269|PubMed:20551322}.; PTM: Phosphorylated. {ECO:0000250|UniProtKB:P54845}.
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
pubmed
11477108
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20551322
uniprot
proteins
pubmed
8288222
uniprot
proteins
sequence_length
237
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P54845}. Nucleus {ECO:0000250|UniProtKB:P54845}.
uniprot
proteins