Dusp4
entrez
319520
canonical
uniprot
Q8BFV3
canonical
ensembl
ENSMUSG00000031530
resolver
ensp
ENSMUSP00000033930
resolver
enst
ENSMUST00000033930
resolver
genesymbol
Dusp4
resolver
uniprot_entry
DUS4_MOUSE
resolver
amino_acid_sequence
MVTMEELREMDCSVLKRLMNRDENGGGGSAGGNGSGSHGALGLLSGGKCLLLDCRPFLAHSAGYIRGSVNVRCNTIVRRRAKGSVSLEQILPAEEEVRARLRSGLYSAVIVYDERSPRAESLREDSTVSLVVQALRRNAERTDICLLKGGYERFSSEYPEFCSKTKALAAIPPPVPPSTNESLDLGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLTTSCAAEAASPSGPLRERGKATPTPTSQFVFSFPVSVGVHAAPSNLPYLHSPITTSPSC
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Regulates mitogenic signal transduction by dephosphorylating both Thr and Tyr residues on MAP kinases ERK1 and ERK2. {ECO:0000250|UniProtKB:Q13115}.
uniprot
proteins
mass_dalton
43372
uniprot
proteins
post_translational_modification
PTM: Phosphorylation in the C-terminus by ERK1/2 inhibits proteasomal degradation and stabilizes the protein. {ECO:0000250|UniProtKB:Q13115}.
uniprot
proteins
protein_family
Non-receptor class dual specificity subfamily
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
398
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q13115}.
uniprot
proteins