S100a4
entrez
20198
canonical
uniprot
P07091
canonical
ensembl
ENSMUSG00000001020
resolver
ensp
ENSMUSP00000001046
resolver
ensp
ENSMUSP00000252590
resolver
ensp
ENSMUSP00000252591
resolver
enst
ENSMUST00000001046
resolver
genesymbol
S100a4
resolver
genesymbol_syn
Capl
resolver
genesymbol_syn
Mts1
resolver
uniprot
P20066
resolver
uniprot
Q545V2
resolver
uniprot_entry
Q545V2_MOUSE
resolver
uniprot_entry
S10A4_MOUSE
resolver
uniprot_sec
P20066
resolver
amino_acid_sequence
MARPLEEALDVIVSTFHKYSGKEGDKFKLNKTELKELLTRELPSFLGKRTDEAAFQKVMSNLDSNRDNEVDFQEYCVFLSCIAMMCNEFFEGCPDKEPRKK
uniprot
proteins
function
FUNCTION: Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy (PubMed:20519440). Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (PubMed:8051043). Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (PubMed:8051043). Also modulates the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (By similarity). Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes (PubMed:20103644). In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (By similarity). {ECO:0000250|UniProtKB:P26447, ECO:0000269|PubMed:20103644, ECO:0000269|PubMed:20519440, ECO:0000269|PubMed:8051043}.
uniprot
proteins
mass_dalton
11721
uniprot
proteins
protein_family
S-100 family
uniprot
proteins
pubmed
20103644
uniprot
proteins
pubmed
20519440
uniprot
proteins
pubmed
2332170
uniprot
proteins
pubmed
2550322
uniprot
proteins
pubmed
3162911
uniprot
proteins
pubmed
3628004
uniprot
proteins
pubmed
8051043
uniprot
proteins
pubmed
8423998
uniprot
proteins
sequence_length
101
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P26447}. Nucleus {ECO:0000250|UniProtKB:P26447}. Cytoplasm {ECO:0000269|PubMed:8051043}.
uniprot
proteins