Acap1
entrez
216859
canonical
uniprot
Q8K2H4
canonical
ensembl
ENSMUSG00000001588
resolver
ensp
ENSMUSP00000001631
resolver
ensp
ENSMUSP00000345702
resolver
enst
ENSMUST00000001631
resolver
genesymbol
Acap1
resolver
genesymbol_syn
Centb1
resolver
genesymbol_syn
Kiaa0050
resolver
uniprot
Q3U441
resolver
uniprot
Q571H6
resolver
uniprot_entry
ACAP1_MOUSE
resolver
uniprot_sec
Q3U441
resolver
uniprot_sec
Q571H6
resolver
activity_regulation
ACTIVITY REGULATION: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid. {ECO:0000250|UniProtKB:Q15027}.
uniprot
proteins
amino_acid_sequence
MTVKLDFEECLKDSPRFRASIELVETEVSELETRLEKLLKLGSCLLESGQHYLAAGRAFVVGICDLARLGPPEPMMAECLEKFTVSLNHKLDSHAELLDATQHTLQQQIQTLVKEGLRGFREARRDFWRGAENLEAALTHNAEVPRRRVQEAEEAGTALRTARAGYRSRALDYALQVNVIEDKRKFDIMEFVLRLVEAQATYFQQGHEELNRLAQYRKELGTQLHNLVLNSARQKRDMEQRHVLLKQKELGGEEPEPSLKEGPSGLVMEGHLFKRASNAFKTWSRRWFTIQNNQLVYQKKYKDPVTVVVDDLRLCTVKLCPDSERRFCFEVVSTSKSCFLQADSERLLQLWVSAVQSSIASAFSQAHLENSPRGPGQVSGYHAPGSAATLACGGAARGRESGGVGQVAAQVQSVDGNAQCCDCREPAPEWASINLGVTLCIQCSGIHRSLGVHFSKVRSLTLDSWEPELVKLMCELGNVIINQIYEARVEAMAVKKPGPSCSRQEKEAWIHAKYVEKKFLTKLPEIRGRRGGRGPPRGHPPVPPKPPIRPHSGIVRSKSECPSDDMGSLHPGALLFQAAGHPPSLPTMADALAHGADVNWVNVGQGNATPLIRATAANSLLACEFLLQNGANVNQADSAGRGPLHHATILGHTGLACLFLKRGADLGARDTEGRDPLTIAMETTNADIVTLLRLAKMREAEAAQGQAGDETYLDIFRDFSLMASDDPEKLSRRSHDLHTL
uniprot
proteins
function
FUNCTION: GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) required for clathrin-dependent export of proteins from recycling endosomes to trans-Golgi network and cell surface. Required for regulated export of ITGB1 from recycling endosomes to the cell surface and ITGB1-dependent cell migration (By similarity). {ECO:0000250, ECO:0000269|PubMed:17664335}.
uniprot
proteins
mass_dalton
81704
uniprot
proteins
mutagenesis
MUTAGEN 448; /note="R->Q: Loss of catalytic activity. No loss of accumulation of coat proteins on internal membranes upon overexpression of Acap1."; /evidence="ECO:0000269|PubMed:17664335
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17664335
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
740
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Recycling endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
uniprot
proteins