ACOX3
entrez
8310
canonical
uniprot
O15254
canonical
ensembl
ENSG00000087008
resolver
ensp
ENSP00000348775
resolver
ensp
ENSP00000413994
resolver
ensp
ENSP00000421625
resolver
ensp
ENSP00000565464
resolver
ensp
ENSP00000565465
resolver
ensp
ENSP00000565467
resolver
ensp
ENSP00000565472
resolver
ensp
ENSP00000593821
resolver
ensp
ENSP00000622686
resolver
ensp
ENSP00000622690
resolver
ensp
ENSP00000677636
resolver
ensp
ENSP00000677637
resolver
ensp
ENSP00000697967
resolver
genesymbol
ACOX3
resolver
genesymbol_syn
BRCOX
resolver
genesymbol_syn
PRCOX
resolver
hgnc
HGNC:121
resolver
uniprot
Q96AJ8
resolver
uniprot_entry
ACOX3_HUMAN
resolver
uniprot_sec
Q96AJ8
resolver
amino_acid_sequence
MASTVEGGDTALLPEFPRGPLDAYRARASFSWKELALFTEGEGMLRFKKTIFSALENDPLFARSPGADLSLEKYRELNFLRCKRIFEYDFLSVEDMFKSPLKVPALIQCLGMYDSSLAAKYLLHSLVFGSAVYSSGSERHLTYIQKIFRMEIFGCFALTELSHGSNTKAIRTTAHYDPATEEFIIHSPDFEAAKFWVGNMGKTATHAVVFAKLCVPGDQCHGLHPFIVQIRDPKTLLPMPGVMVGDIGKKLGQNGLDNGFAMFHKVRVPRQSLLNRMGDVTPEGTYVSPFKDVRQRFGASLGSLSSGRVSIVSLAILNLKLAVAIALRFSATRRQFGPTEEEEIPVLEYPMQQWRLLPYLAAVYALDHFSKSLFLDLVELQRGLASGDRSARQAELGREIHALASASKPLASWTTQQGIQECREACGGHGYLAMNRLGVLRDDNDPNCTYEGDNNILLQQTSNYLLGLLAHQVHDGACFRSPLKSVDFLDAYPGILDQKFEVSSVADCLDSAVALAAYKWLVCYLLRETYQKLNQEKRSGSSDFEARNKCQVSHGRPLALAFVELTVVQRFHEHVHQPSVPPSLRAVLGRLSALYALWSLSRHAALLYRGGYFSGEQAGEVLESAVLALCSQLKDDAVALVDVIAPPDFVLDSPIGRADGELYKNLWGAVLQESKVLERASWWPEFSVNKPVIGSLKSKL
uniprot
proteins
ec_number
1.3.3.6
uniprot
proteins
function
FUNCTION: Involved in peroxisomal beta-oxidation of branched-chain fatty acids (BCFAs). Catalyzes the initial and rate-limiting dehydrogenation step that removes two hydrogen molecules and introduces a trans double bond between the alpha and beta carbons of the acyl CoA molecules while generating hydrogen peroxide as a by-product (PubMed:29287774). Metabolizes multi-methyl-branched fatty acyl-CoA esters such as (2S)-pristanoyl-CoA, displaying redundancy with ACOX3 (PubMed:29287774). Can oxidize straight-chain mono- and dicarboxylyl fatty acyl-CoAs with lower efficiency (By similarity) (PubMed:29287774). {ECO:0000250|UniProtKB:Q63448, ECO:0000269|PubMed:29287774}.; FUNCTION: Oxidizes the CoA-esters of 2-methyl-branched fatty acids. {ECO:0000250|UniProtKB:Q63448}.
uniprot
proteins
mass_dalton
77629
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; peroxisomal fatty acid beta-oxidation. {ECO:0000305|PubMed:29287774}.
uniprot
proteins
protein_family
Acyl-CoA oxidase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29287774
uniprot
proteins
pubmed
9271077
uniprot
proteins
sequence_length
700
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome {ECO:0000250|UniProtKB:Q63448}.
uniprot
proteins