Smc3
entrez
13006
canonical
uniprot
Q9CW03
canonical
ensembl
ENSMUSG00000024974
resolver
ensp
ENSMUSP00000025930
resolver
enst
ENSMUST00000025930
resolver
genesymbol
Smc3
resolver
genesymbol_syn
Bam
resolver
genesymbol_syn
Bmh
resolver
genesymbol_syn
Cspg6
resolver
genesymbol_syn
Mmip1
resolver
genesymbol_syn
Smc3l1
resolver
genesymbol_syn
Smcd
resolver
uniprot
O35667
resolver
uniprot
Q1HL32
resolver
uniprot
Q3TMK9
resolver
uniprot
Q9QUS3
resolver
uniprot_entry
Q1HL32_MOUSE
resolver
uniprot_entry
Q3TMK9_MOUSE
resolver
uniprot_entry
SMC3_MOUSE
resolver
uniprot_sec
O35667
resolver
uniprot_sec
Q9QUS3
resolver
amino_acid_sequence
MYIKQVIIQGFRSYRDQTIVDPFSSKHNVIVGRNGSGKSNFFYAIQFVLSDEFSHLRPEQRLALLHEGTGPRVISAFVEIIFDNSDNRLPIDKEEVSLRRVIGAKKDQYFLDKKMVTKNDVMNLLESAGFSRSNPYYIVKQGKINQMATAPDSQRLKLLREVAGTRVYDERKEESISLMKETEGKREKINELLKYIEERLHTLEEEKEELAQYQKWDKMRRALEYTIYNQELNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQLSAERQEQIKQRTKLELKAKDLQDELAGNSEQRKRLLKERQKLLEKIEEKQKELAETEPKFNSVKEKEERGIARLAQATQERTDLYAKQGRGSQFTSKEERDKWIKKELKSLDQAINDKKRQIAAIHKDLEDTEANKEKNLEQYNKLDQDLNEVKARVEELDRKYYEVKNKKDELQSERNYLWREENAEQQALAAKREDLEKKQQLLRAATGKAILNGIDSINKVLEHFRRKGINQHVQNGYHGIVMNNFECEPAFYTCVEVTAGNRLFYHIVDSDEVSTKILMEFNKMNLPGEVTFLPLNKLDVRDTAYPETNDAIPMISKLRYNPRFDKAFKHVFGKTLICRSMEVSTQLARAFTMDCITLEGDQVSHRGALTGGYYDTRKSRLELQKDVRKAEEELGELEAKLNENLRRNIERINNEIDQLMNQMQQIETQQRKFKASRDSILSEMKMLKEKRQQSEKTFMPKQRSLQSLEASLHAMESTRESLKAELGTDLLSQLSLEDQKRVDALNDEIRQLQQENRQLLNERIKLEGIITRVETYLNENLRKRLDQVEQELNELRETEGGTVLTATTSELEAINKRVKDTMARSEDLDNSIDKTEAGIKELQKSMERWKNMEKEHMDAINHDTKELEKMTNRQGMLLKKKEECMKKIRELGSLPQEAFEKYQTLSLKQLFRKLEQCNTELKKYSHVNKKALDQFVNFSEQKEKLIKRQEELDRGYKSIMELMNVLELRKYEAIQLTFKQVSKNFSEVFQKLVPGGKATLVMKKGDVEGSQSQDEGEGSGESERGSGSQSSVPSVDQFTGVGIRVSFTGKQGEMREMQQLSGGQKSLVALALIFAIQKCDPAPFYLFDEIDQALDAQHRKAVSDMIMELAVHAQFITTTFRPELLESADKFYGVKFRNKVSHIDVITAEMAKDFVEDDTTHG
uniprot
proteins
function
FUNCTION: Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement. {ECO:0000269|PubMed:10375619}.
uniprot
proteins
mass_dalton
141556
uniprot
proteins
mutagenesis
MUTAGEN 807; /note="L->P: Abolishes interaction with MXI1."; /evidence="ECO:0000269|PubMed:9528857
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-1083 in a SPO11-dependent manner. {ECO:0000269|PubMed:15378723, ECO:0000269|PubMed:22346761}.; PTM: Acetylation at Lys-105 and Lys-106 by ESCO1 is important for genome stability and S phase sister chromatid cohesion. Regulated by DSCC1, it is required for processive DNA synthesis, coupling sister chromatid cohesion establishment during S phase to DNA replication (By similarity). Deacetylation by HDAC8, regulates release of the cohesin complex from chromatin (By similarity). {ECO:0000250|UniProtKB:Q9UQE7}.; PTM: Ubiquitinated by the DCX(DCAF15) complex, leading to its degradation. {ECO:0000250|UniProtKB:Q9UQE7}.
uniprot
proteins
protein_family
SMC family
uniprot
proteins
protein_family
SMC3 subfamily
uniprot
proteins
pubmed
10358101
uniprot
proteins
pubmed
10375619
uniprot
proteins
pubmed
11483963
uniprot
proteins
pubmed
11564881
uniprot
proteins
pubmed
15378723
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22346761
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
24287868
uniprot
proteins
pubmed
9528857
uniprot
proteins
sequence_length
1217
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:22346761}. Chromosome {ECO:0000269|PubMed:22346761, ECO:0000269|PubMed:24287868}. Chromosome, centromere {ECO:0000269|PubMed:22346761}. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. The phosphorylated form at Ser-1083 is preferentially associated with unsynapsed chromosomal regions.
uniprot
proteins