AZU1
entrez
566
canonical
uniprot
P20160
canonical
ensembl
ENSG00000172232
resolver
ensembl
ENSG00000278624
resolver
ensp
ENSP00000233997
resolver
ensp
ENSP00000479183
resolver
enst
ENST00000233997
resolver
enst
ENST00000620695
resolver
genesymbol
AZU1
resolver
hgnc
HGNC:913
resolver
uniprot
P80014
resolver
uniprot
Q52LG4
resolver
uniprot
Q9UCM1
resolver
uniprot
Q9UCT5
resolver
uniprot_entry
CAP7_HUMAN
resolver
uniprot_sec
P80014
resolver
uniprot_sec
Q52LG4
resolver
uniprot_sec
Q9UCM1
resolver
uniprot_sec
Q9UCT5
resolver
amino_acid_sequence
MTRLTVLALLAGLLASSRAGSSPLLDIVGGRKARPRQFPFLASIQNQGRHFCGGALIHARFVMTAASCFQSQNPGVSTVVLGAYDLRRRERQSRQTFSISSMSENGYDPQQNLNDLMLLQLDREANLTSSVTILPLPLQNATVEAGTRCQVAGWGSQRSGGRLSRFPRFVNVTVTPEDQCRPNNVCTGVLTRRGGICNGDGGTPLVCEGLAHGVASFSLGPCGRGPDFFTRVALFRDWIDGVLNNPGPGPA
uniprot
proteins
function
FUNCTION: This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G. {ECO:0000269|PubMed:1399008, ECO:0000269|PubMed:1937776, ECO:0000269|PubMed:2312733}.
uniprot
proteins
mass_dalton
26886
uniprot
proteins
mutagenesis
MUTAGEN 52; /note="C->S: Loss of antibiotic activity."; /evidence="ECO:0000269|PubMed:8506327"; MUTAGEN 68; /note="C->S: Loss of antibiotic activity."; /evidence="ECO:0000269|PubMed:8506327
uniprot
proteins
post_translational_modification
PTM: Cleavage of the N-terminal propeptide which is composed of 7 amino acids occurs in two steps. The initial cleavage of 5 amino acids is followed by the cleavage of a dipeptide to produce the mature form. {ECO:0000269|PubMed:10534120}.
uniprot
proteins
protein_family
Elastase subfamily
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
10534120
uniprot
proteins
pubmed
1399008
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
1518849
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1755383
uniprot
proteins
pubmed
1897955
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
1919011
uniprot
proteins
pubmed
1937776
uniprot
proteins
pubmed
2026172
uniprot
proteins
pubmed
2049091
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2226832
uniprot
proteins
pubmed
2312733
uniprot
proteins
pubmed
2332502
uniprot
proteins
pubmed
2404977
uniprot
proteins
pubmed
2406527
uniprot
proteins
pubmed
2501794
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26274980
uniprot
proteins
pubmed
8506327
uniprot
proteins
pubmed
9095193
uniprot
proteins
pubmed
9761855
uniprot
proteins
sequence_length
251
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic granule membrane {ECO:0000269|PubMed:2312733, ECO:0000269|PubMed:2501794}; Peripheral membrane protein {ECO:0000269|PubMed:2312733}; Cytoplasmic side {ECO:0000269|PubMed:2312733}. Note=Localizes to azurophil granules of neutrophil granulocytes. Also called primary granules, these specialized lysosomes of the neutrophil formed early during promyelocyte development store antibacterial proteins and peptides. {ECO:0000269|PubMed:2312733, ECO:0000269|PubMed:2501794}.
uniprot
proteins