Pemt
entrez
18618
canonical
uniprot
Q61907
canonical
ensembl
ENSMUSG00000000301
resolver
ensp
ENSMUSP00000000310
resolver
ensp
ENSMUSP00000099753
resolver
ensp
ENSMUSP00000099754
resolver
ensp
ENSMUSP00000116314
resolver
ensp
ENSMUSP00000276321
resolver
genesymbol
Pemt
resolver
genesymbol_syn
Pempt
resolver
genesymbol_syn
Pemt2
resolver
uniprot
Q3UZN8
resolver
uniprot
Q7TNW6
resolver
uniprot
Q8R0I1
resolver
uniprot_entry
PEMT_MOUSE
resolver
uniprot_sec
Q3UZN8
resolver
uniprot_sec
Q7TNW6
resolver
uniprot_sec
Q8R0I1
resolver
amino_acid_sequence
MSWLLGYMDPTEPSFVAAVITIVFNPLFWNVVARWEQRTRKLSRAFGSPHLACYSLGICILLLNILRSHCFTQAMMSQPKMEGLDNHTTYFLGLAFLGWGFVFVLSSFYALGFTGTFLGDYFGILKESRVTTFPFSVLDNPMYWGSTANYLGWALMHASPTGLLLTVLVAIVYVVALLYEEPFTAEIYRQKATRLHKRS
uniprot
proteins
ec_number
2.1.1.17
uniprot
proteins
ec_number
2.1.1.71
uniprot
proteins
function
FUNCTION: Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure (Probable) (PubMed:9371769). Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step (PubMed:9371769). {ECO:0000269|PubMed:9371769, ECO:0000305|PubMed:9765216}.
uniprot
proteins
mass_dalton
22579
uniprot
proteins
pathway_participation
PATHWAY: Phospholipid metabolism; phosphatidylcholine biosynthesis. {ECO:0000305|PubMed:9371769}.
uniprot
proteins
protein_family
Class VI-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
PEMT/PEM2 methyltransferase family
uniprot
proteins
pubmed
12482759
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8978486
uniprot
proteins
pubmed
9371769
uniprot
proteins
pubmed
9765216
uniprot
proteins
sequence_length
199
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9UBM1}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03216}. Mitochondrion membrane {ECO:0000255|HAMAP-Rule:MF_03216}; Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_03216}. Note=Found in endoplasmic reticulum where most PEMT activity is generated and in mitochondria. {ECO:0000250|UniProtKB:Q9UBM1}.
uniprot
proteins
transmembrane_region
TRANSMEM 46..66; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03216"; TRANSMEM 94..114; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03216"; TRANSMEM 158..178; /note="Helical"; /evidence="ECO:0000255|HAMAP-Rule:MF_03216
uniprot
proteins