CKB
entrez
1152
canonical
uniprot
P12277
canonical
ensembl
ENSG00000166165
resolver
ensp
ENSP00000299198
resolver
ensp
ENSP00000508488
resolver
ensp
ENSP00000625450
resolver
enst
ENST00000348956
resolver
enst
ENST00000689346
resolver
enst
ENST00000955391
resolver
genesymbol
CKB
resolver
genesymbol
HEL-S-29
resolver
genesymbol_syn
CKB
resolver
genesymbol_syn
CKBB
resolver
hgnc
HGNC:1991
resolver
uniprot
A0A0S2Z471
resolver
uniprot
A0A8I5KRX7
resolver
uniprot
A8K236
resolver
uniprot
B2R5R4
resolver
uniprot
Q2LE07
resolver
uniprot
Q6FG40
resolver
uniprot
Q9UC66
resolver
uniprot
V9HWH2
resolver
uniprot_entry
A0A0S2Z471_HUMAN
resolver
uniprot_entry
A0A8I5KRX7_HUMAN
resolver
uniprot_entry
KCRB_HUMAN
resolver
uniprot_entry
V9HWH2_HUMAN
resolver
uniprot_sec
A8K236
resolver
uniprot_sec
B2R5R4
resolver
uniprot_sec
Q2LE07
resolver
uniprot_sec
Q6FG40
resolver
uniprot_sec
Q9UC66
resolver
amino_acid_sequence
MPFSNSHNALKLRFPAEDEFPDLSAHNNHMAKVLTPELYAELRAKSTPSGFTLDDVIQTGVDNPGHPYIMTVGCVAGDEESYEVFKDLFDPIIEDRHGGYKPSDEHKTDLNPDNLQGGDDLDPNYVLSSRVRTGRSIRGFCLPPHCSRGERRAIEKLAVEALSSLDGDLAGRYYALKSMTEAEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKTFLVWVNEEDHLRVISMQKGGNMKEVFTRFCTGLTQIETLFKSKDYEFMWNPHLGYILTCPSNLGTGLRAGVHIKLPNLGKHEKFSEVLKRLRLQKRGTGGVDTAAVGGVFDVSNADRLGFSEVELVQMVVDGVKLLIEMEQRLEQGQAIDDLMPAQK
uniprot
proteins
ec_number
2.7.3.2
uniprot
proteins
function
FUNCTION: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate) (PubMed:8186255). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (Probable). Acts as a key regulator of adaptive thermogenesis as part of the futile creatine cycle: localizes to the mitochondria of thermogenic fat cells and acts by mediating phosphorylation of creatine to initiate a futile cycle of creatine phosphorylation and dephosphorylation (By similarity). During the futile creatine cycle, creatine and N-phosphocreatine are in a futile cycle, which dissipates the high energy charge of N-phosphocreatine as heat without performing any mechanical or chemical work (By similarity). {ECO:0000250|UniProtKB:Q04447, ECO:0000269|PubMed:8186255, ECO:0000305}.
uniprot
proteins
mass_dalton
42644
uniprot
proteins
mutagenesis
MUTAGEN 283; /note="C->S,Y: Complete loss of activity."; /evidence="ECO:0000269|PubMed:8186255"; MUTAGEN 292; /note="R->H,L,Q: Complete loss of activity."; /evidence="ECO:0000269|PubMed:8186255"; MUTAGEN 292; /note="R->K: 42% of wild-type activity."; /evidence="ECO:0000269|PubMed:8186255"; MUTAGEN 340; /note="D->E: No change in activity."; /evidence="ECO:0000269|PubMed:8186255
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the ECS(ASB9) complex, leading to its degradation by the proteasome. {ECO:0000269|PubMed:33268465}.
uniprot
proteins
protein_family
ATP:guanido phosphotransferase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18566107
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18977227
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22905912
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
2771648
uniprot
proteins
pubmed
2828370
uniprot
proteins
pubmed
2883200
uniprot
proteins
pubmed
3034271
uniprot
proteins
pubmed
32513959
uniprot
proteins
pubmed
33268465
uniprot
proteins
pubmed
3692484
uniprot
proteins
pubmed
7637327
uniprot
proteins
pubmed
8186255
uniprot
proteins
sequence_length
381
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q04447}. Mitochondrion {ECO:0000250|UniProtKB:Q04447}. Cell membrane {ECO:0000269|PubMed:18566107}. Note=Localizes to the mitochondria of thermogenic fat cells via the internal MTS-like signal (iMTS-L) region. {ECO:0000250|UniProtKB:Q04447}.
uniprot
proteins