Gria4
entrez
29629
canonical
uniprot
P19493
canonical
ensembl
ENSRNOG00000006957
resolver
ensp
ENSRNOP00000009542
resolver
ensp
ENSRNOP00000068876
resolver
ensp
ENSRNOP00000068940
resolver
enst
ENSRNOT00000009542
resolver
enst
ENSRNOT00000078765
resolver
enst
ENSRNOT00000081171
resolver
genesymbol
Gria4
resolver
genesymbol_syn
Glur4
resolver
uniprot
A0A0G2JTX0
resolver
uniprot
A0A0G2JU28
resolver
uniprot
G3V6W1
resolver
uniprot
Q566D4
resolver
uniprot
Q64241
resolver
uniprot_entry
A0A0G2JTX0_RAT
resolver
uniprot_entry
A0A0G2JU28_RAT
resolver
uniprot_entry
G3V6W1_RAT
resolver
uniprot_entry
GRIA4_RAT
resolver
uniprot_entry
Q566D4_RAT
resolver
uniprot_sec
Q64241
resolver
amino_acid_sequence
MRIICRQIVLLFSGFWGLAMGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEGESQFVLQLRPSLRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVTKLMDRWKKLDQREYPGSETPPKYTSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDMPTLGNDTAAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYTEQRKPCDTMKVGGNLDSKGYGVATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKLTFSEATRNKARLSITGSVGENGRVLTPDCPKAVHTGTAIRQSSGLAVIASDLP
uniprot
proteins
function
FUNCTION: Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (PubMed:12603841, PubMed:1372042, PubMed:19102704, PubMed:20107073, PubMed:2166337, PubMed:26966189). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission (By similarity). Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium (PubMed:1370372, PubMed:19102704). The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:19102704, PubMed:26966189). In the presence of CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate (By similarity). {ECO:0000250|UniProtKB:P42262, ECO:0000250|UniProtKB:P48058, ECO:0000269|PubMed:12603841, ECO:0000269|PubMed:1370372, ECO:0000269|PubMed:1372042, ECO:0000269|PubMed:19102704, ECO:0000269|PubMed:20107073, ECO:0000269|PubMed:2166337, ECO:0000269|PubMed:26966189}.
uniprot
proteins
mass_dalton
100758
uniprot
proteins
mutagenesis
MUTAGEN 407; /note="N->Q: No effect on surface expression and channel activity; when associated with Q-414."; /evidence="ECO:0000269|PubMed:12603841"; MUTAGEN 414; /note="N->Q: No effect on surface expression and channel activity; when associated with Q-407."; /evidence="ECO:0000269|PubMed:12603841
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. Depalmitoylated upon L-glutamate stimulation. ZDHHC3/GODZ specifically palmitoylates Cys-611, which leads to Golgi retention and decreased cell surface expression. In contrast, Cys-837 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis. {ECO:0000250|UniProtKB:P23819}.; PTM: Phosphorylated at Ser-862 by PRKCG; phosphorylation increases plasma membrane-associated GRI4 expression. {ECO:0000269|PubMed:12471040}.
uniprot
proteins
protein_family
GRIA4 subfamily
uniprot
proteins
protein_family
Glutamate-gated ion channel (TC 1.A.10.1) family
uniprot
proteins
pubmed
10027300
uniprot
proteins
pubmed
12471040
uniprot
proteins
pubmed
12574408
uniprot
proteins
pubmed
12603841
uniprot
proteins
pubmed
1370372
uniprot
proteins
pubmed
1372042
uniprot
proteins
pubmed
1699275
uniprot
proteins
pubmed
18817736
uniprot
proteins
pubmed
19022251
uniprot
proteins
pubmed
19102704
uniprot
proteins
pubmed
19234459
uniprot
proteins
pubmed
19265014
uniprot
proteins
pubmed
1977421
uniprot
proteins
pubmed
20107073
uniprot
proteins
pubmed
2166337
uniprot
proteins
pubmed
24090084
uniprot
proteins
pubmed
26966189
uniprot
proteins
sequence_length
902
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12574408, ECO:0000269|PubMed:12603841}; Multi-pass membrane protein. Postsynaptic cell membrane; Multi-pass membrane protein. Cell projection, dendrite {ECO:0000269|PubMed:12471040}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P42262}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P42262}.
uniprot
proteins
transmembrane_region
TRANSMEM 545..565; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 618..638; /note="Helical"; /evidence="ECO:0000250"; TRANSMEM 814..834; /note="Helical; Name=M4"; /evidence="ECO:0000250
uniprot
proteins