P21396
uniprot
P21396
canonical
amino_acid_sequence
MTDLEKPNLAGHMFDVGLIGGGISGLAAAKLLSEYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQNRILRLSKELGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWNPLAYLDYNNLWRTMDEMGKEIPVDAPWQARHAQEWDKMTMKDLIDKICWTKTAREFAYLFVNINVTSEPHEVSALWFLWYVRQCGGTARIFSVTNGGQERKFVGGSGQVSEQIMGLLGDKVKLSSPVTYIDQTDDNIIVETLNHEHYECKYVISAIPPILTAKIHFKPELPPERNQLIQRLPMGAVIKCMVYYKEAFWKKKDYCGCMIIEDEEAPIAITLDDTKPDGSLPAIMGFILARKADRQAKLHKDIRKRKICELYAKVLGSQEALYPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKVAKKDIWVEEPESKDVPAIEITHTFLERNLPSVPGLLKITGVSTSVALLCFVLYKIKKLPC
uniprot
proteins
ec_number
1.4.3.21
uniprot
proteins
ec_number
1.4.3.4
uniprot
proteins
function
FUNCTION: Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:18391214, PubMed:9162023). Preferentially oxidizes serotonin (PubMed:20493079). Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline (PubMed:18391214). {ECO:0000269|PubMed:18391214, ECO:0000269|PubMed:20493079, ECO:0000269|PubMed:9162023}.
uniprot
proteins
mass_dalton
59508
uniprot
proteins
mutagenesis
MUTAGEN 208; /note="F->A: Lower affinity for serotonin and tyramine; no change for tryptamine."; /evidence="ECO:0000269|PubMed:9162023"; MUTAGEN 208; /note="F->I: Lower affinity for serotonin and tyramine; no change for tryptamine."; /evidence="ECO:0000269|PubMed:9162023"; MUTAGEN 208; /note="F->V: Lower affinity for serotonin and tyramine; no change for tryptamine."; /evidence="ECO:0000269|PubMed:9162023"; MUTAGEN 208; /note="F->Y: No change in substrate affinity."; /evidence="ECO:0000269|PubMed:9162023
uniprot
proteins
protein_family
Flavin monoamine oxidase family
uniprot
proteins
pubmed
1368522
uniprot
proteins
pubmed
15050826
uniprot
proteins
pubmed
1526120
uniprot
proteins
pubmed
18391214
uniprot
proteins
pubmed
20493079
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9162023
uniprot
proteins
sequence_length
526
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:15050826}; Single-pass type IV membrane protein {ECO:0000269|PubMed:15050826}; Cytoplasmic side {ECO:0000269|PubMed:15050826}.
uniprot
proteins
transmembrane_region
TRANSMEM 498..518; /note="Helical; Anchor for type IV membrane protein
uniprot
proteins