Oxt
entrez
18429
canonical
uniprot
P35454
canonical
ensembl
ENSMUSG00000027301
resolver
ensp
ENSMUSP00000028764
resolver
enst
ENSMUST00000028764
resolver
genesymbol
Oxt
resolver
uniprot
Q545V4
resolver
uniprot_entry
NEU1_MOUSE
resolver
uniprot_entry
Q545V4_MOUSE
resolver
amino_acid_sequence
MACPSLACCLLGLLALTSACYIQNCPLGGKRAVLDLDMRKCLPCGPGGKGRCFGPSICCADELGCFVGTAEALRCQEENYLPSPCQSGQKPCGSGGRCAATGICCSPDGCRTDPACDPESAFSER
uniprot
proteins
function
FUNCTION: Precursor of oxytocin, a neurohypophyseal hormone that plays a key role in social interactions and neurophysin 1, its carrier protein. {ECO:0000269|PubMed:2176709}.; FUNCTION: [Oxytocin]: Neuropeptide hormone released by the posterior pituitary gland that plays a key role in social behavior and other biological processes, such as milk ejection (PubMed:10888874, PubMed:25303526, PubMed:25874674, PubMed:26375004, PubMed:27641503, PubMed:28963257, PubMed:30944474, PubMed:34381215, PubMed:37730989, PubMed:38267576, PubMed:40934325, PubMed:8876199, PubMed:8933362). Released in response to a variety of social cues and acts by binding to oxytocin receptor (OXTR), triggering signaling that modulates neural circuits by altering ion channel activity, changing intrinsic neuronal properties and modifying synaptic transmission (both excitatory and inhibitory) (PubMed:25303526, PubMed:25874674, PubMed:26375004, PubMed:27641503, PubMed:28963257, PubMed:30944474, PubMed:37730989, PubMed:38267576). Central release (direct secretion in the brain) plays essential roles in social behavior, such as maternal care, female mating behavior, social cognition and affiliative behaviors (PubMed:16537524, PubMed:25303526, PubMed:25874674, PubMed:26375004, PubMed:27641503, PubMed:28963257, PubMed:30944474, PubMed:34381215, PubMed:37730989, PubMed:38267576, PubMed:40267134, PubMed:40934325). Stressful and anxiogenic stimuli promote release of oxytocin, which acts as a powerful modulator of anxiety- and stress-related behaviors (By similarity). Modulates neural circuits related to reward, fear and social approach, encouraging care and cooperation, but can also increase guilt or aggression towards out-groups (By similarity). Beyond its role in social behavior, plays a role in other processes, such as parturition, lactation or osteoblast differentiation, when released peripherally (secreted from the posterior pituitary gland into the bloodstream) (PubMed:19369205, PubMed:31843930, PubMed:8876199, PubMed:8933362). Required for parturition and milk ejection by triggering and strengthening contraction of the smooth muscle of the uterus and mammary gland, respectively (By similarity). Promotes bone mass by stimulating bone formation by osteoblasts (PubMed:19369205, PubMed:31843930). {ECO:0000250|UniProtKB:P01178, ECO:0000269|PubMed:10888874, ECO:0000269|PubMed:16537524, ECO:0000269|PubMed:19369205, ECO:0000269|PubMed:25303526, ECO:0000269|PubMed:25874674, ECO:0000269|PubMed:26375004, ECO:0000269|PubMed:27641503, ECO:0000269|PubMed:28963257, ECO:0000269|PubMed:30944474, ECO:0000269|PubMed:31843930, ECO:0000269|PubMed:34381215, ECO:0000269|PubMed:37730989, ECO:0000269|PubMed:38267576, ECO:0000269|PubMed:40267134, ECO:0000269|PubMed:40934325, ECO:0000269|PubMed:8876199, ECO:0000269|PubMed:8933362}.; FUNCTION: [Neurophysin 1]: Carrier protein that binds to and transports oxytocin from the hypothalamus to the posterior pituitary gland, protecting it from degradation and facilitating its release. {ECO:0000250|UniProtKB:P01179}.
uniprot
proteins
mass_dalton
12851
uniprot
proteins
post_translational_modification
PTM: Synthesized as a large inactive precursor protein (pro-OXT), which is cleaved into oxytocin and neurophysin 1 by endopeptidases, such as neuroendocrine convertases PCSK1 and PCSK2 (PubMed:17467653). Oxytocin is then amidated at the C-terminus, completing its activation (PubMed:9562574). {ECO:0000269|PubMed:17467653, ECO:0000269|PubMed:9562574}.; PTM: [Oxytocin]: Amidated at the C-terminus by alpha-amidating monooxygenase (PAM), completing its activation. {ECO:0000269|PubMed:9562574}.
uniprot
proteins
protein_family
Vasopressin/oxytocin family
uniprot
proteins
pubmed
10888874
uniprot
proteins
pubmed
11471062
uniprot
proteins
pubmed
16537524
uniprot
proteins
pubmed
17467653
uniprot
proteins
pubmed
19369205
uniprot
proteins
pubmed
2176709
uniprot
proteins
pubmed
25303526
uniprot
proteins
pubmed
25874674
uniprot
proteins
pubmed
26375004
uniprot
proteins
pubmed
27641503
uniprot
proteins
pubmed
28963257
uniprot
proteins
pubmed
30944474
uniprot
proteins
pubmed
31843930
uniprot
proteins
pubmed
34381215
uniprot
proteins
pubmed
37730989
uniprot
proteins
pubmed
38267576
uniprot
proteins
pubmed
40267134
uniprot
proteins
pubmed
40934325
uniprot
proteins
pubmed
8876199
uniprot
proteins
pubmed
8933362
uniprot
proteins
pubmed
9562574
uniprot
proteins
pubmed
9751758
uniprot
proteins
sequence_length
125
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:P01179}. Note=The precursor protein (pro-OXT) is packaged into neurosecretory granules. {ECO:0000250|UniProtKB:P01179}.; SUBCELLULAR LOCATION: [Oxytocin]: Secreted {ECO:0000250|UniProtKB:P01179}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:P01179}. Note=Following processing, oxytocin and neurophysin 1 are transported to the posterior pituitary and stored in neurosecretory granules at the nerve termini until secreted. {ECO:0000250|UniProtKB:P01179}.; SUBCELLULAR LOCATION: [Neurophysin 1]: Secreted {ECO:0000250|UniProtKB:P01179}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:P01179}. Note=Following processing, oxytocin and neurophysin 1 are transported to the posterior pituitary and stored in neurosecretory granules at the nerve termini until secreted. {ECO:0000250|UniProtKB:P01179}.
uniprot
proteins