Fignl2
entrez
102555469
canonical
uniprot
A0A8I6AGW3
canonical
ensembl
ENSRNOG00000032026
resolver
ensembl
ENSRNOG00055027963
resolver
ensembl
ENSRNOG00060015555
resolver
ensembl
ENSRNOG00065022417
resolver
ensp
ENSRNOP00000099701
resolver
ensp
ENSRNOP00000105512
resolver
ensp
ENSRNOP00000105682
resolver
ensp
ENSRNOP00000110043
resolver
ensp
ENSRNOP00055039786
resolver
ensp
ENSRNOP00060021282
resolver
ensp
ENSRNOP00065030940
resolver
enst
ENSRNOT00000124801
resolver
enst
ENSRNOT00000140915
resolver
enst
ENSRNOT00000169082
resolver
enst
ENSRNOT00000173592
resolver
enst
ENSRNOT00055048388
resolver
enst
ENSRNOT00060026607
resolver
enst
ENSRNOT00065038217
resolver
genesymbol
Fignl2
resolver
uniprot_entry
FIGL2_RAT
resolver
amino_acid_sequence
MHWTPEHAQPLNQWPEQHLDVSSTTPSPAHKLELPPGGRQRCHYAWAHDDISALTASNLLKRYAEKYSGVLDSPYERPGLGSYGDAAFLNGAKADPEPWPGPEPPYPLASLHEGLPGAKPAGAGGSAGLGGSPVVAGNLTEPLYTGNACGGPSAATEYAAGYGGGYLASGYCAQTSAALAPPPPAALLQPAPPPGYGPSAPLYNYPAAGYAAQPGYGALPPPAAPPAPYLPSGLAAPTPLPAPAPAPPRPAPYGFPGAAEGVSLKRKAVDEGAEARYRKYAYEPAKAPAADGAAYPAADDAECRGNGFRAKPPGTTEDGTGKYGGGGSLKVLGSPAYAPQLEPFDKFAERVPAAHGGFAEPSGEPAKGVDPGTLELVSSKMVDCGPPVQWADVAGQGALKAALEEELLWPLLRPPACPGSARPPRTVLFFGPRGCGKALLGRCLATRLGATLLRLRGAGLATSGAVEGARLLQAAFAAARCRPPAVLLISELDALLPARDDGASLRAPLLTCLDGGCGARADGVLVVGTTSRPAALDEATRRRFALRFYVALPDGAARGQILQRALAQQGCVLSERELAALVQGTQGFSGGELGQLCQQAAAEAGLSGLQRPLSYKEVEAALAKVGPRAPPKELDSLVEWDKMYGSGH
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: Microtubule-severing enzyme that negatively regulates cell migration and wound healing (By similarity). In migrating cells, targets dynamic microtubules (MTs) at the leading edge and severs them, thereby suppressing motility (By similarity). Microtubule severing releases ARHGEF2 which activates RHOA, which in turn regulates focal ahesion turnover via focal adhesion kinase, as opposed to F-actin polymerization, to suppress cell motility (By similarity). Negative regulator of axon regeneration that suppresses axonal growth by selectively severing dynamic MTs in the distal axon shaft and growth cone (PubMed:33872220). Contributes to proper cell branching during endothelial and neuronal development (By similarity). {ECO:0000250|UniProtKB:A6NMB9, ECO:0000250|UniProtKB:E9QEA3, ECO:0000269|PubMed:33872220}.
uniprot
proteins
mass_dalton
66314
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
33872220
uniprot
proteins
sequence_length
648
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:J3QK54}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:A6NMB9}. Note=Localizes at the leading edge of migrating cells. {ECO:0000250|UniProtKB:A6NMB9}.
uniprot
proteins