TRAF4
entrez
9618
canonical
uniprot
Q9BUZ4
canonical
ensembl
ENSG00000076604
resolver
ensp
ENSP00000262395
resolver
genesymbol
TRAF4
resolver
genesymbol_syn
CART1
resolver
genesymbol_syn
MLN62
resolver
genesymbol_syn
RNF83
resolver
hgnc
HGNC:12034
resolver
uniprot
O75615
resolver
uniprot
Q14848
resolver
uniprot
Q2KJU4
resolver
uniprot
Q2PJN8
resolver
uniprot_entry
TRAF4_HUMAN
resolver
uniprot_sec
O75615
resolver
uniprot_sec
Q14848
resolver
uniprot_sec
Q2KJU4
resolver
uniprot_sec
Q2PJN8
resolver
amino_acid_sequence
MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFLSEGVFKCPEDQLPLDYAKIYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQGHLNTCSFNVIPCPNRCPMKLSRRDLPAHLQHDCPKRRLKCEFCGCDFSGEAYESHEGMCPQESVYCENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQSHQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGCKHRCPKLAMARHVEESVKPHLAMMCALVSRQRQELQELRRELEELSVGSDGVLIWKIGSYGRRLQEAKAKPNLECFSPAFYTHKYGYKLQVSAFLNGNGSGEGTHLSLYIRVLPGAFDNLLEWPFARRVTFSLLDQSDPGLAKPQHVTETFHPDPNWKNFQKPGTWRGSLDESSLGFGYPKFISHQDIRKRNYVRDDAVFIRAAVELPRKILS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Adapter protein with E3 ligase activity that is involved in many diverse biological processes including cell proliferation, migration, differentiation, DNA repair, platelet activation or apoptosis (PubMed:30352854, PubMed:31076633, PubMed:32268273, PubMed:33991522). Promotes EGFR-mediated signaling by facilitating the dimerization of EGFR and downstream AKT activation thereby promoting cell proliferation (PubMed:30352854). Ubiquitinates SMURF2 through 'Lys-48'-linked ubiquitin chain leading to SMURF2 degradation through the proteasome and subsequently osteogenic differentiation (PubMed:31076633). Promotes 'Lys-63'-mediated ubiquitination of CHK1 which in turn activates cell cycle arrest and activation of DNA repair (PubMed:32357935). In addition, promotes an atypical 'Lys-29'-linked ubiquitination at the C-terminal end of IRS1 which is crucial for insulin-like growth factor (IGF) signal transduction (PubMed:33991522). Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Inhibits adipogenic differentiation by activating pyruvate kinase PKM activity and subsequently the beta-catenin signaling pathway (PubMed:32268273). {ECO:0000250, ECO:0000269|PubMed:12023963, ECO:0000269|PubMed:12801526, ECO:0000269|PubMed:16052631, ECO:0000269|PubMed:16157600, ECO:0000269|PubMed:18953416, ECO:0000269|PubMed:19937093, ECO:0000269|PubMed:30352854, ECO:0000269|PubMed:31076633, ECO:0000269|PubMed:32268273, ECO:0000269|PubMed:32357935, ECO:0000269|PubMed:33991522}.
uniprot
proteins
mass_dalton
53543
uniprot
proteins
mutagenesis
MUTAGEN 18; /note="C->A: Complete loss of E3 ligase activity."; /evidence="ECO:0000269|PubMed:32357935
uniprot
proteins
pathway_participation
PATHWAY: Protein degradation; proteasomal ubiquitin-dependent pathway. {ECO:0000269|PubMed:31076633, ECO:0000269|PubMed:32357935, ECO:0000269|PubMed:33991522}.
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated, leading to its proteasomal degradation (PubMed:19937093). Ubiquitinated at Lys-263 by the SCF(FBXL2) complex, leading to its degradation by the proteasome (By similarity). {ECO:0000250|UniProtKB:Q61382, ECO:0000269|PubMed:19937093}.
uniprot
proteins
protein_family
B subfamily
uniprot
proteins
protein_family
TNF receptor-associated factor family
uniprot
proteins
pubmed
10514511
uniprot
proteins
pubmed
12023963
uniprot
proteins
pubmed
12801526
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16052631
uniprot
proteins
pubmed
16157600
uniprot
proteins
pubmed
16330715
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
18087216
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18953416
uniprot
proteins
pubmed
19937093
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20946164
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
29073066
uniprot
proteins
pubmed
30352854
uniprot
proteins
pubmed
31076633
uniprot
proteins
pubmed
32268273
uniprot
proteins
pubmed
32357935
uniprot
proteins
pubmed
33991522
uniprot
proteins
pubmed
7490069
uniprot
proteins
pubmed
7592751
uniprot
proteins
pubmed
9626059
uniprot
proteins
sequence_length
470
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:32268273}. Nucleus {ECO:0000269|PubMed:32268273}. Cytoplasm, perinuclear region. Cell junction, tight junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton {ECO:0000305}.
uniprot
proteins