Dkc1
entrez
245474
canonical
uniprot
Q9ESX5
canonical
ensembl
ENSMUSG00000031403
resolver
ensp
ENSMUSP00000033776
resolver
enst
ENSMUST00000033776
resolver
genesymbol
Dkc1
resolver
uniprot
Q3UWE5
resolver
uniprot_entry
DKC1_MOUSE
resolver
uniprot_sec
Q3UWE5
resolver
amino_acid_sequence
MADAEVITFPKKHKKKKDRKPLQEDDVAEIQHAEEFLIKPESKVAQLDTSQWPLLLKNFDKLNVRTAHYTPLPCGSNPLKREIGDYIRTGFINLDKPSNPSSHEVVAWIRRILRVEKTGHSGTLDPKVTGCLIVCIERATRLVKSQQSAGKEYVGIVRLHNAIEGGTQLSRALETLTGALFQRPPLIAAVKRQLRVRTIYESKMIEYDPERRLGIFWVSCEAGTYIRTLCVHLGLLLGVGGQMQELRRVRSGVMSEKDHMVTMHDVLDAQWLYDNHKDESYLRRVVYPLEKLLTSHKRLVMKDSAVNAICYGAKIMLPGLLRYEDGIEVNQEIVVITTKGEAICMAIALMTTAVISTCDHGIVAKIKRVIMERDTYPRKWGLGPKASQKKMMIKQGLLDKHGKPTDNTPATWKQDYIDYSDSGKNTLVTEAVQAPQLAAEAVNVIKRKRDSESESDETPTVPQLKEKKKKKDKKPKTVLESGGETGDGDNDTTKKKKKKKVKVVEEMSE
uniprot
proteins
ec_number
5.4.99.-
uniprot
proteins
function
FUNCTION: Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA (PubMed:12522253, PubMed:15240872). This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ('psi') residues, which may serve to stabilize the conformation of rRNAs (PubMed:12522253, PubMed:15240872). Required for ribosome biogenesis and telomere maintenance (By similarity). Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity). {ECO:0000250|UniProtKB:O60832, ECO:0000269|PubMed:12522253, ECO:0000269|PubMed:15240872}.
uniprot
proteins
mass_dalton
57402
uniprot
proteins
mutagenesis
MUTAGEN 353; /note="A->V: Destabilization of TERC, impaired telomerase function, and reduced rRNA pseudouridylation and pre-rRNA processing."; /evidence="ECO:0000269|PubMed:15240872"; MUTAGEN 402; /note="G->E: Reduced rRNA pseudouridylation and pre-rRNA processing."; /evidence="ECO:0000269|PubMed:15240872
uniprot
proteins
protein_family
Pseudouridine synthase TruB family
uniprot
proteins
pubmed
10903840
uniprot
proteins
pubmed
12522253
uniprot
proteins
pubmed
15240872
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18630941
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
509
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:O60832}. Nucleus, Cajal body {ECO:0000250|UniProtKB:P40615}.
uniprot
proteins