Fbxl15
entrez
309453
canonical
uniprot
D4ABB4
canonical
ensembl
ENSRNOG00000019509
resolver
ensembl
ENSRNOG00055004485
resolver
ensembl
ENSRNOG00060028934
resolver
ensembl
ENSRNOG00065030109
resolver
ensp
ENSRNOP00000026471
resolver
ensp
ENSRNOP00055005296
resolver
ensp
ENSRNOP00060041871
resolver
ensp
ENSRNOP00065042768
resolver
enst
ENSRNOT00055007099
resolver
enst
ENSRNOT00060050252
resolver
enst
ENSRNOT00065051958
resolver
genesymbol
Fbxl15
resolver
uniprot_entry
FXL15_RAT
resolver
amino_acid_sequence
MEPPMEQSGGEQEPGAVRLLDLPWEDVLLPHVLNWVPLRQLLRLQRVSRAFRALVQLHLARLRRFDAAQVGPQIPRAALVRLLRDAEGLQELALAPCHEWLLDEDLVPVLARNPQLRSVALAGCGQLSRRALGALAEGCPRLQRISLAHCDWVDGLALRGLADRCPALEELDLTACRQLKDEAIVYLAQRRGAGLRSLSLAVNANVGDTAVQELARNCPQLEHLDLTGCLRVGSDGVRTLAEYCPALRSLRVRHCHHVAEPSLSRLRKRGVDIDVEPPLHQALVLLQDMAGFAPFVNLQV
uniprot
proteins
function
FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity). Required for bone mass maintenance. {ECO:0000250, ECO:0000269|PubMed:21572392}.
uniprot
proteins
mass_dalton
33180
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
FBXL15 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
21572392
uniprot
proteins
sequence_length
300
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins