Gdf2
entrez
12165
canonical
uniprot
Q9WV56
canonical
ensembl
ENSMUSG00000072625
resolver
ensp
ENSMUSP00000098286
resolver
enst
ENSMUST00000100720
resolver
genesymbol
Gdf2
resolver
genesymbol_syn
Bmp9
resolver
uniprot
Q3ZAS6
resolver
uniprot
Q9QZE0
resolver
uniprot_entry
GDF2_MOUSE
resolver
uniprot_sec
Q3ZAS6
resolver
uniprot_sec
Q9QZE0
resolver
amino_acid_sequence
MSPGAFRVALLPLFLLVCVTQQKPLQNWEQASPGENAHSSLGLSGAGEEGVFDLQMFLENMKVDFLRSLNLSGIPSQDKTRAEPPQYMIDLYNRYTTDKSSTPASNIVRSFSVEDAISTAATEDFPFQKHILIFNISIPRHEQITRAELRLYVSCQNDVDSTHGLEGSMVVYDVLEDSETWDQATGTKTFLVSQDIRDEGWETLEVSSAVKRWVRADSTTNKNKLEVTVQSHRESCDTLDISVPPGSKNLPFFVVFSNDRSNGTKETRLELKEMIGHEQETMLVKTAKNAYQVAGESQEEEGLDGYTAVGPLLARRKRSTGASSHCQKTSLRVNFEDIGWDSWIIAPKEYDAYECKGGCFFPLADDVTPTKHAIVQTLVHLKFPTKVGKACCVPTKLSPISILYKDDMGVPTLKYHYEGMSVAECGCR
uniprot
proteins
function
FUNCTION: Potent circulating inhibitor of angiogenesis (By similarity). Signals through the type I activin receptor ACVRL1 but not other Alks (PubMed:25751889). Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG (PubMed:23300529). {ECO:0000250|UniProtKB:Q9UK05, ECO:0000269|PubMed:23300529, ECO:0000269|PubMed:25751889}.
uniprot
proteins
mass_dalton
47703
uniprot
proteins
post_translational_modification
PTM: A reversible disulfide bond can be formed between the two subunits in the homodimer; this has no effect on GDF2 activity. {ECO:0000250|UniProtKB:Q9UK05}.
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23300529
uniprot
proteins
pubmed
25751889
uniprot
proteins
sequence_length
428
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9UK05}.
uniprot
proteins