EIPR1
entrez
7260
canonical
uniprot
Q53HC9
canonical
ensembl
ENSG00000032389
resolver
ensp
ENSP00000371559
resolver
ensp
ENSP00000381652
resolver
enst
ENST00000382125
resolver
enst
ENST00000398659
resolver
genesymbol
EIPR1
resolver
genesymbol_syn
TSSC1
resolver
hgnc
HGNC:12383
resolver
uniprot
A8MUM1
resolver
uniprot
D6W4Y1
resolver
uniprot
O43179
resolver
uniprot
Q53S19
resolver
uniprot
Q53SG2
resolver
uniprot_entry
A8MUM1_HUMAN
resolver
uniprot_entry
EIPR1_HUMAN
resolver
uniprot_sec
D6W4Y1
resolver
uniprot_sec
O43179
resolver
uniprot_sec
Q53S19
resolver
uniprot_sec
Q53SG2
resolver
amino_acid_sequence
MEDDAPVIYGLEFQARALTPQTAETDAIRFLVGTQSLKYDNQIHIIDFDDENNIINKNVLLHQAGEIWHISASPADRGVLTTCYNRTSDSKVLTCAAVWRMPKELESGSHESPDDSSSTAQTLELLCHLDNTAHGNMACVVWEPMGDGKKIISLADNHILLWDLQESSSQAVLASSASLEGKGQLKFTSGRWSPHHNCTQVATANDTTLRGWDTRSMSQIYCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKTLEEHSHWVWNVRYNHSHDQLVLTGSSDSRVILSNMVSISSEPFGHLVDDDDISDQEDHRSEEKSKEPLQDNVIATYEEHEDSVYAVDWSSADPWLFASLSYDGRLVINRVPRALKYHILL
uniprot
proteins
function
FUNCTION: Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network (PubMed:27440922). Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein (PubMed:27440922). Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex (PubMed:27440922). Controls proper insulin distribution and secretion, and retention of cargo in mature dense core vesicles (By similarity). Required for the stability of the endosome-associated retrograde protein (EARP) complex subunits and for proper localization and association of EARP with membranes (By similarity). {ECO:0000250|UniProtKB:Q5PPK9, ECO:0000269|PubMed:27440922}.
uniprot
proteins
mass_dalton
43603
uniprot
proteins
protein_family
WD repeat EIPR1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
27440922
uniprot
proteins
pubmed
9403053
uniprot
proteins
sequence_length
387
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:27440922}.
uniprot
proteins