Lss
entrez
81681
canonical
uniprot
P48450
canonical
ensembl
ENSRNOG00000054549
resolver
ensp
ENSRNOP00000069432
resolver
enst
ENSRNOT00000078412
resolver
genesymbol
Lss
resolver
genesymbol_syn
Osc
resolver
uniprot
A0A0G2JVC8
resolver
uniprot
Q62811
resolver
uniprot_entry
A0A0G2JVC8_RAT
resolver
uniprot_entry
LSS_RAT
resolver
uniprot_sec
Q62811
resolver
amino_acid_sequence
MTEGTCLRRRGGPYKTEPATDLTRWRLHNELGRQRWTYYQAEEDPGREQTGLEAHSLGLDTTSYFKNLPKAQTAHEGALNGVTFYAKLQAEDGHWAGDYGGPLFLLPGLLITCHIAHIPLPAGYREEMVRYLRSVQLPDGGWGLHIEDKSTVFGTALSYVSLRILGIGPDDPDLVRARNILHKKGGAVAIPSWGKFWLAVLNVYSWEGINTLFPEMWLLPEWFPAHPSTLWCHCRQVYLPMSYCYATRLSASEDPLVQSLRQELYVEDYASIDWPAQKNNVCPDDMYTPHSWLLHVVYGLLNLYERFHSTSLRKWAIQLLYEHVAADDRFTKCISIGPISKTVNMLIRWSVDGPSSPAFQEHVSRIKDYLWLGLDGMKMQGTNGSQTWDTSFAVQALLEAGAHRRPEFLPCLQKAHEFLRLSQVPDNNPDYQKYYRHMHKGGFPFSTLDCGWIVADCTAEALKAVLLLQERCPSITEHVPRERLYDAVAVLLSMRNSDGGFATYETKRGGYLLELLNPSEVFGDIMIDYTYVECTSAVMQALRHFREYFPDHRATESRETLNQGLDFCRKKQRADGSWEGSWGVCFTYGTWFGLEAFACMGHIYQNRTACAEVAQACHFLLSRQMADGGWGEDFESCEQRRYVQSAGSQVHSTCWALLGLMAVRHPDISAQERGIRCLLGKQLPNGDWPQENISGVFNKSCAISYTNYRNIFPIWALGRFSSLYPDNTLAGHI
uniprot
proteins
ec_number
5.4.99.7
uniprot
proteins
function
FUNCTION: Key enzyme in the cholesterol biosynthesis pathway. Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus (PubMed:7568116). Through the production of lanosterol may regulate lens protein aggregation and increase transparency (By similarity). {ECO:0000250|UniProtKB:P48449, ECO:0000269|PubMed:7568116}.
uniprot
proteins
mass_dalton
83301
uniprot
proteins
pathway_participation
PATHWAY: Terpene metabolism; lanosterol biosynthesis; lanosterol from farnesyl diphosphate: step 3/3.
uniprot
proteins
protein_family
Terpene cyclase/mutase family
uniprot
proteins
pubmed
16440058
uniprot
proteins
pubmed
7568116
uniprot
proteins
pubmed
7735243
uniprot
proteins
sequence_length
733
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P48449}; Peripheral membrane protein {ECO:0000250|UniProtKB:P48449}.
uniprot
proteins