Trim63
entrez
140939
canonical
uniprot
Q91Z63
canonical
ensembl
ENSRNOG00000016543
resolver
ensembl
ENSRNOG00055024636
resolver
ensembl
ENSRNOG00060031813
resolver
ensp
ENSRNOP00000058869
resolver
ensp
ENSRNOP00055034617
resolver
ensp
ENSRNOP00060045555
resolver
enst
ENSRNOT00055042390
resolver
enst
ENSRNOT00060055110
resolver
genesymbol
Trim63
resolver
genesymbol_syn
Murf1
resolver
uniprot_entry
TRI63_RAT
resolver
amino_acid_sequence
MDYKSGLIPDGNAMENLEKQLICPICLEMFTKPVVILPCQHNLCRKCANDIFQAANPYWTNRGGSVSMSGGRFRCPSCRHEVIMDRHGVYGLQRNLLVENIIDIYKQECSSRPLQKGSHPMCKEHEDEKINIYCLTCEVPTCSLCKVFGAHQACEVAPLQSIFQGQKTELSNCISMLVAGNDRVQTIISQLEDSCRVTKENSHQVKEELSHKFDALYAILDEKKSELLQRITQEQEEKLDFIEALILQYREQLEKSTKLVETAIQSLDEPGGATFLLSAKPLIKSIVEASKGCQLGKTEQGFENMDYFTLNLEHIAEALRAIDFGTDEEEEFTEEEEEEDQEEGVSTEGHQ
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells. {ECO:0000269|PubMed:11679633, ECO:0000269|PubMed:15596539}.
uniprot
proteins
mass_dalton
39723
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
11679633
uniprot
proteins
pubmed
11927605
uniprot
proteins
pubmed
12672461
uniprot
proteins
pubmed
12782319
uniprot
proteins
pubmed
14718385
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15596539
uniprot
proteins
pubmed
15827064
uniprot
proteins
pubmed
15963672
uniprot
proteins
sequence_length
351
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, myofibril, sarcomere, M line {ECO:0000250}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:11927605}. Note=Colocalizes with TNNI3 in myocytes. Localizes to the M- and Z-lines in skeletal muscle (By similarity). {ECO:0000250}.
uniprot
proteins