Camk2d
entrez
24246
canonical
uniprot
P15791
canonical
ensembl
ENSRNOG00000011589
resolver
ensembl
ENSRNOG00055025344
resolver
ensembl
ENSRNOG00060002897
resolver
ensembl
ENSRNOG00065014455
resolver
ensp
ENSRNOP00000016026
resolver
ensp
ENSRNOP00000076650
resolver
ensp
ENSRNOP00000082444
resolver
ensp
ENSRNOP00000085967
resolver
enst
ENSRNOT00000094868
resolver
enst
ENSRNOT00000111056
resolver
genesymbol
Camk2d
resolver
uniprot
A0A8I5YBF2
resolver
uniprot
A0A8I5ZUY3
resolver
uniprot
P97915
resolver
uniprot
P97916
resolver
uniprot
Q3B7L0
resolver
uniprot
Q63904
resolver
uniprot
Q63905
resolver
uniprot
Q63906
resolver
uniprot
Q63907
resolver
uniprot
Q63908
resolver
uniprot_entry
A0A8I5YBF2_RAT
resolver
uniprot_entry
A0A8I5ZUY3_RAT
resolver
uniprot_entry
KCC2D_RAT
resolver
uniprot_sec
P97915
resolver
uniprot_sec
P97916
resolver
uniprot_sec
Q3B7L0
resolver
uniprot_sec
Q63904
resolver
uniprot_sec
Q63905
resolver
uniprot_sec
Q63906
resolver
uniprot_sec
Q63907
resolver
uniprot_sec
Q63908
resolver
activity_regulation
ACTIVITY REGULATION: Activated by Ca(2+)/calmodulin. Binding of calmodulin results in conformational change that relieves intrasteric autoinhibition and allows autophosphorylation of Thr-287 which turns the kinase in a constitutively active form and confers to the kinase a Ca(2+)-independent activity.
uniprot
proteins
amino_acid_sequence
MASTTTCTRFTDEYQLFEELGKGAFSVVRRCMKIPTGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGFHYLVFDLVTGGELFEDIVAREYYSEADASHCIQQILESVNHCHLNGIVHRDLKPENLLLASKSKGAAVKLADFGLAIEVQGDQQAWFGFAGTPGYLSPEVLRKDPYGKPVDMWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPAKRITASEALKHPWICQRSTVASMMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSAAKSLLKKPDGVKINNKANVVTSPKENIPTPALEPQTTVIHNPDGNKESTESSNTTIEDEDVKARKQEIIKVTEQLIEAINNGDFEAYTKICDPGLTAFEPEALGNLVEGMDFHRFYFENALPKINKPIHTIILNPHVHLVGDDAACIAYIRLTQYMDGNGMPKTMQSEETRVWHRRDGKWQNIHFHRSGSPTVPIKPPCIPNGKENFSGGTSLWQNI
uniprot
proteins
ec_number
2.7.11.17
uniprot
proteins
function
FUNCTION: Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca(2+) homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca(2+) influx into the myocyte, Ca(2+) release from the sarcoplasmic reticulum (SR), SR Ca(2+) uptake and Na(+) and K(+) channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca(2+) release via direct phosphorylation of RYR2 Ca(2+) channel on 'Ser-2808' (PubMed:17923476). In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program (PubMed:17923476). Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca(2+) influx to myocytes by binding and phosphorylating the L-type Ca(2+) channel subunit beta-2 CACNB2. In addition to Ca(2+) channels, can target and regulate the cardiac sarcolemmal Na(+) channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca(2+) uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis (PubMed:10825152). May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca(2+) transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity). {ECO:0000250|UniProtKB:Q13557, ECO:0000250|UniProtKB:Q6PHZ2, ECO:0000269|PubMed:10825152, ECO:0000269|PubMed:17923476}.
uniprot
proteins
mass_dalton
60081
uniprot
proteins
post_translational_modification
PTM: Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
CaMK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10825152
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16891908
uniprot
proteins
pubmed
17923476
uniprot
proteins
pubmed
18056528
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2553697
uniprot
proteins
pubmed
8224201
uniprot
proteins
pubmed
8390994
uniprot
proteins
sequence_length
533
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Sarcoplasmic reticulum membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform Delta 1]: Nucleus.
uniprot
proteins