NPM3
entrez
10360
canonical
uniprot
O75607
canonical
ensembl
ENSG00000107833
resolver
ensp
ENSP00000359128
resolver
ensp
ENSP00000589598
resolver
enst
ENST00000370110
resolver
enst
ENST00000919539
resolver
genesymbol
NPM3
resolver
hgnc
HGNC:7931
resolver
uniprot
Q9UNY6
resolver
uniprot_entry
NPM3_HUMAN
resolver
uniprot_sec
Q9UNY6
resolver
amino_acid_sequence
MAAGTAAALAFLSQESRTRAGGVGGLRVPAPVTMDSFFFGCELSGHTRSFTFKVEEEDDAEHVLALTMLCLTEGAKDECNVVEVVARNHDHQEIAVPVANLKLSCQPMLSLDDFQLQPPVTFRLKSGSGPVRITGRHQIVTMSNDVSEEESEEEEEDSDEEEVELCPILPAKKQGGRP
uniprot
proteins
function
FUNCTION: Plays a role in the regulation of diverse cellular processes such as ribosome biogenesis, chromatin remodeling or protein chaperoning (PubMed:20073534, PubMed:22362753). Modulates the histone chaperone function and the RNA-binding activity of nucleolar phosphoprotein B23/NPM (PubMed:22362753). Efficiently mediates chromatin remodeling when included in a pentamer containing NPM3 and NPM (PubMed:15596447). {ECO:0000269|PubMed:15596447, ECO:0000269|PubMed:20073534, ECO:0000269|PubMed:22362753}.
uniprot
proteins
mass_dalton
19344
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000305}.
uniprot
proteins
protein_family
Nucleoplasmin family
uniprot
proteins
pubmed
11722795
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15596447
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20073534
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22362753
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
178
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11722795}. Nucleus, nucleolus {ECO:0000269|PubMed:15596447, ECO:0000269|PubMed:22362753}. Note=Mainly found in the granular component of the nucleolus. {ECO:0000269|PubMed:22362753}.
uniprot
proteins