EHBP1
entrez
23301
canonical
uniprot
Q8NDI1
canonical
ensembl
ENSG00000115504
resolver
ensp
ENSP00000263991
resolver
ensp
ENSP00000384143
resolver
ensp
ENSP00000385524
resolver
ensp
ENSP00000403783
resolver
ensp
ENSP00000531175
resolver
ensp
ENSP00000531177
resolver
ensp
ENSP00000531178
resolver
ensp
ENSP00000531179
resolver
ensp
ENSP00000531182
resolver
ensp
ENSP00000531183
resolver
ensp
ENSP00000531184
resolver
ensp
ENSP00000531185
resolver
ensp
ENSP00000531186
resolver
ensp
ENSP00000616078
resolver
genesymbol
EHBP1
resolver
genesymbol_syn
KIAA0903
resolver
genesymbol_syn
NACSIN
resolver
hgnc
HGNC:29144
resolver
uniprot
A0A140VK17
resolver
uniprot
A8K930
resolver
uniprot
O94977
resolver
uniprot
Q53TG7
resolver
uniprot
Q53TV6
resolver
uniprot
Q580X2
resolver
uniprot
Q6NX72
resolver
uniprot
Q6PIT3
resolver
uniprot
Q6QNV2
resolver
uniprot
Q9NWI9
resolver
uniprot_entry
A0A140VK17_HUMAN
resolver
uniprot_entry
A8K930_HUMAN
resolver
uniprot_entry
EHBP1_HUMAN
resolver
uniprot_sec
O94977
resolver
uniprot_sec
Q53TG7
resolver
uniprot_sec
Q53TV6
resolver
uniprot_sec
Q580X2
resolver
uniprot_sec
Q6NX72
resolver
uniprot_sec
Q6PIT3
resolver
uniprot_sec
Q6QNV2
resolver
uniprot_sec
Q9NWI9
resolver
amino_acid_sequence
MASVWKRLQRVGKHASKFQFVASYQELMVECTKKWQPDKLVVVWTRRSRRKSSKAHSWQPGIKNPYRGVVVWPVPENIEITVTLFKDPHAEEFEDKEWTFVIENESPSGRRKALATSSINMKQYASPMPTQTDVKLKFKPLSKKVVSAALQFSLSCIFLREGKATDEDMQSLASLMSMKQADIGNLDDFEEDNEDDDENRVNQEEKAAKITEIVNQLNALSSLDEDQDDCIKQANMRSAKSASSSEELINKLNFLDEAEKDLATVNSNPFDDPDAAELNPFGDPDSEEPITETASPRKTEDSFYNNSYNPFKEVQTPQYLNPFDEPEAFVTIKDSPPQSTKRKNIRPVDMSKYLYADSSKTEEEELDESNPFYEPKSTPPPNNLVNPVQELETERRVKRKAPAPPVLSPKTGVLNENTVSAGKDLSTSPKPSPIPSPVLGRKPNASQSLLVWCKEVTKNYRGVKITNFTTSWRNGLSFCAILHHFRPDLIDYKSLNPQDIKENNKKAYDGFASIGISRLLEPSDMVLLAIPDKLTVMTYLYQIRAHFSGQELNVVQIEENSSKSTYKVGNYETDTNSSVDQEKFYAELSDLKREPELQQPISGAVDFLSQDDSVFVNDSGVGESESEHQTPDDHLSPSTASPYCRRTKSDTEPQKSQQSSGRTSGSDDPGICSNTDSTQAQVLLGKKRLLKAETLELSDLYVSDKKKDMSPPFICEETDEQKLQTLDIGSNLEKEKLENSRSLECRSDPESPIKKTSLSPTSKLGYSYSRDLDLAKKKHASLRQTESDPDADRTTLNHADHSSKIVQHRLLSRQEELKERARVLLEQARRDAALKAGNKHNTNTATPFCNRQLSDQQDEERRRQLRERARQLIAEARSGVKMSELPSYGEMAAEKLKERSKASGDENDNIEIDTNEEIPEGFVVGGGDELTNLENDLDTPEQNSKLVDLKLKKLLEVQPQVANSPSSAAQKAVTESSEQDMKSGTEDLRTERLQKTTERFRNPVVFSKDSTVRKTQLQSFSQYIENRPEMKRQRSIQEDTKKGNEEKAAITETQRKPSEDEVLNKGFKDTSQYVVGELAALENEQKQIDTRAALVEKRLRYLMDTGRNTEEEEAMMQEWFMLVNKKNALIRRMNQLSLLEKEHDLERRYELLNRELRAMLAIEDWQKTEAQKRREQLLLDELVALVNKRDALVRDLDAQEKQAEEEDEHLERTLEQNKGKMAKKEEKCVLQ
uniprot
proteins
disease_involvement
DISEASE: Prostate cancer, hereditary, 12 (HPC12) [MIM:611868]: A condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma. {ECO:0000269|PubMed:18264098}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). {ECO:0000250|UniProtKB:Q69ZW3, ECO:0000269|PubMed:14676205, ECO:0000305|PubMed:27552051}.
uniprot
proteins
mass_dalton
140017
uniprot
proteins
post_translational_modification
PTM: Prenylated (Probable). Farnelysation (predominant) and geranylgeranylation has been observed in vitro. {ECO:0000269|PubMed:27552051}.
uniprot
proteins
pubmed
10048485
uniprot
proteins
pubmed
14676205
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18264098
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27552051
uniprot
proteins
sequence_length
1231
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14676205}. Membrane {ECO:0000269|PubMed:14676205}. Endosome {ECO:0000305|PubMed:27552051}. Note=Mostly found in cytosol and plasma membrane.
uniprot
proteins