Tomm6
entrez
66119
canonical
uniprot
Q9CQN3
canonical
ensembl
ENSMUSG00000033475
resolver
ensp
ENSMUSP00000108926
resolver
ensp
ENSMUSP00000108927
resolver
enst
ENSMUST00000113301
resolver
enst
ENSMUST00000113302
resolver
genesymbol
Tomm6
resolver
genesymbol_syn
Obtp
resolver
genesymbol_syn
Tom6
resolver
uniprot_entry
TOM6_MOUSE
resolver
amino_acid_sequence
MASSGVTVSAAGSASEASEVPDNVGDWLRGVFRFATDRNDFRRNLILNLGLFAAGVWLARNLSDIDLMAPQPGV
uniprot
proteins
function
FUNCTION: Component of the translocase of the outer membrane of mitochondria (TOM) complex essential for the recognition and translocation of cytosolically synthesized mitochondrial preproteins (By similarity). The TOM complex associates with the ion channel VDAC2 and PINK1 kinase at depolarized mitochondria, this interaction stabilizes PINK1 at the outer mitochondrial membrane and triggers downstream mitophagy by the recruitment of the E3 ubiquitin ligase PRKN (By similarity). {ECO:0000250|UniProtKB:Q96B49}.
uniprot
proteins
mass_dalton
7865
uniprot
proteins
protein_family
Tom6 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
74
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q96B49}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q96B49}.
uniprot
proteins
transmembrane_region
TRANSMEM 41..64; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q96B49
uniprot
proteins