Ier3ip1
entrez
66191
canonical
uniprot
Q9CR20
canonical
ensembl
ENSMUSG00000090000
resolver
ensp
ENSMUSP00000026487
resolver
enst
ENSMUST00000026487
resolver
genesymbol
Ier3ip1
resolver
uniprot_entry
IR3IP_MOUSE
resolver
amino_acid_sequence
MAFTLYSLMQAALLCVNAIAVLHEERFLKNIGWGTDQGIGGFGEEPGIKSQLMNLIRSVRTVMRVPLIIVNSITIVLLLLFG
uniprot
proteins
function
FUNCTION: Regulator of endoplasmic reticulum secretion that acts as a key determinant of brain size. Required for secretion of extracellular matrix proteins. Required for correct brain development by depositing sufficient extracellular matrix proteins for tissue integrity and the proliferation of neural progenitors (By similarity). Acts as a regulator of the unfolded protein response (UPR) (PubMed:28915629). {ECO:0000250|UniProtKB:Q9Y5U9, ECO:0000269|PubMed:28915629}.
uniprot
proteins
mass_dalton
9017
uniprot
proteins
protein_family
YOS1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
28915629
uniprot
proteins
sequence_length
82
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Y5U9}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 2..22; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 62..82; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins