Nedd8
entrez
18002
canonical
uniprot
P29595
canonical
ensembl
ENSMUSG00000010376
resolver
ensp
ENSMUSP00000010520
resolver
enst
ENSMUST00000010520
resolver
genesymbol
Nedd8
resolver
genesymbol_syn
Nedd-8
resolver
uniprot
Q3UI46
resolver
uniprot_entry
NEDD8_MOUSE
resolver
uniprot_entry
Q3UI46_MOUSE
resolver
amino_acid_sequence
MLIKVKTLTGKEIEIDIEPTDKVERIKERVEEKEGIPPQQQRLIYSGKQMNDEKTAADYKILGGSVLHLVLALRGGGGLGQ
uniprot
proteins
function
FUNCTION: Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis via its conjugation to a limited number of cellular proteins, such as cullins or p53/TP53 (PubMed:11696557). Attachment of NEDD8 to cullins is critical for the recruitment of E2 to the cullin-RING-based E3 ubiquitin-protein ligase complex, thus facilitating polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. Attachment of NEDD8 to p53/TP53 inhibits p53/TP53 transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M (By similarity). Neddylates EGFR resulting in protein stabilization and translocation to the cell membrane (By similarity). {ECO:0000250|UniProtKB:Q15843, ECO:0000269|PubMed:11696557}.
uniprot
proteins
mass_dalton
8972
uniprot
proteins
post_translational_modification
PTM: Cleavage of precursor form by UCHL3 or SENP8 is necessary for function. {ECO:0000250|UniProtKB:Q15843}.
uniprot
proteins
protein_family
Ubiquitin family
uniprot
proteins
pubmed
10597293
uniprot
proteins
pubmed
11696557
uniprot
proteins
pubmed
12215427
uniprot
proteins
pubmed
1378265
uniprot
proteins
pubmed
15183309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
8395831
uniprot
proteins
pubmed
9353319
uniprot
proteins
sequence_length
81
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12215427}. Note=Mainly nuclear. {ECO:0000269|PubMed:12215427}.
uniprot
proteins