MAD2L1BP
entrez
9587
canonical
uniprot
Q15013
canonical
ensembl
ENSG00000124688
resolver
ensp
ENSP00000361244
resolver
ensp
ENSP00000410818
resolver
genesymbol
MAD2L1BP
resolver
genesymbol_syn
CMT2
resolver
genesymbol_syn
KIAA0110
resolver
hgnc
HGNC:21059
resolver
uniprot
B4DLV3
resolver
uniprot
E9PAT7
resolver
uniprot
Q6IBB1
resolver
uniprot_entry
MD2BP_HUMAN
resolver
uniprot_sec
B4DLV3
resolver
uniprot_sec
E9PAT7
resolver
uniprot_sec
Q6IBB1
resolver
amino_acid_sequence
MAAPEAEVLSSAAVPDLEWYEKSEETHASQIELLETSSTQEPLNASEAFCPRDCMVPVVFPGPVSQEGCCQFTCELLKHIMYQRQQLPLPYEQLKHFYRKPSPQAEEMLKKKPRATTEVSSRKCQQALAELESVLSHLEDFFARTLVPRVLILLGGNALSPKEFYELDLSLLAPYSVDQSLSTAACLRRLFRAIFMADAFSELQAPPLMGTVVMAQGHRNCGEDWFRPKLNYRVPSRGHKLTVTLSCGRPSIRTTAWEDYIWFQAPVTFKGFRE
uniprot
proteins
function
FUNCTION: May function to silence the spindle checkpoint and allow mitosis to proceed through anaphase by binding MAD2L1 after it has become dissociated from the MAD2L1-CDC20 complex. {ECO:0000269|PubMed:18022368}.
uniprot
proteins
mass_dalton
31052
uniprot
proteins
mutagenesis
MUTAGEN 83; /note="Q->A: Loss of interaction with MAD2L1 and disruption of ability to overcome spindle checkpoint-dependent mitotic arrest; when associated with A-191."; /evidence="ECO:0000269|PubMed:18022368"; MUTAGEN 191; /note="F->A: Loss of interaction with MAD2L1 and disruption of ability to overcome spindle checkpoint-dependent mitotic arrest; when associated with A-83."; /evidence="ECO:0000269|PubMed:18022368
uniprot
proteins
protein_family
MAD2L1BP family
uniprot
proteins
pubmed
12456649
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18022368
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
7788527
uniprot
proteins
sequence_length
274
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton, spindle. Note=During early mitosis, unevenly distributed throughout the nucleoplasm. From metaphase to anaphase, concentrated on the spindle.
uniprot
proteins