RSPO3
entrez
84870
canonical
uniprot
Q9BXY4
canonical
ensembl
ENSG00000146374
resolver
ensp
ENSP00000349131
resolver
genesymbol
RSPO3
resolver
genesymbol_syn
PWTSR
resolver
genesymbol_syn
THSD2
resolver
hgnc
HGNC:20866
resolver
uniprot
B2RC27
resolver
uniprot
Q5VTV4
resolver
uniprot
Q96K87
resolver
uniprot_entry
RSPO3_HUMAN
resolver
uniprot_sec
B2RC27
resolver
uniprot_sec
Q5VTV4
resolver
uniprot_sec
Q96K87
resolver
amino_acid_sequence
MHLRLISWLFIILNFMEYIGSQNASRGRRQRRMHPNVSQGCQGGCATCSDYNGCLSCKPRLFFALERIGMKQIGVCLSSCPSGYYGTRYPDINKCTKCKADCDTCFNKNFCTKCKSGFYLHLGKCLDNCPEGLEANNHTMECVSIVHCEVSEWNPWSPCTKKGKTCGFKRGTETRVREIIQHPSAKGNLCPPTNETRKCTVQRKKCQKGERGKKGRERKRKKPNKGESKEAIPDSKSLESSKEIPEQRENKQQQKKRKVQDKQKSVSVSTVH
uniprot
proteins
function
FUNCTION: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors, which acts as a key regulator of angiogenesis. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway (PubMed:21727895, PubMed:21909076, PubMed:22615920). Acts as a key regulator of angiogenesis by controlling vascular stability and pruning: acts by activating the non-canonical Wnt signaling pathway in endothelial cells (By similarity) (PubMed:21727895, PubMed:21909076, PubMed:22615920). Can also amplify Wnt signaling pathway independently of LGR4-6 receptors, possibly by acting as a direct antagonistic ligand to RNF43 and ZNRF3 (PubMed:29769720). {ECO:0000250|UniProtKB:Q2TJ95, ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:21909076, ECO:0000269|PubMed:22615920, ECO:0000269|PubMed:29769720}.
uniprot
proteins
mass_dalton
30929
uniprot
proteins
mutagenesis
MUTAGEN 106; /note="F->A: Loss of LGR4/5/6-binding, no effect on WNT3A signaling; when associated with A-110."; /evidence="ECO:0000269|PubMed:29769720"; MUTAGEN 110; /note="F->A: Loss of LGR4/5/6-binding, no effect on WNT3A signaling; when associated with A-106."; /evidence="ECO:0000269|PubMed:29769720
uniprot
proteins
protein_family
R-spondin family
uniprot
proteins
pubmed
12463421
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21727895
uniprot
proteins
pubmed
21909076
uniprot
proteins
pubmed
22615920
uniprot
proteins
pubmed
26766444
uniprot
proteins
pubmed
29769720
uniprot
proteins
sequence_length
272
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q2TJ95}.
uniprot
proteins