Il18
entrez
16173
canonical
uniprot
P70380
canonical
ensembl
ENSMUSG00000039217
resolver
ensp
ENSMUSP00000137193
resolver
ensp
ENSMUSP00000150305
resolver
ensp
ENSMUSP00000151002
resolver
enst
ENSMUST00000180021
resolver
enst
ENSMUST00000213916
resolver
enst
ENSMUST00000214117
resolver
genesymbol
Il18
resolver
genesymbol_syn
Igif
resolver
uniprot
A0A1L1STF5
resolver
uniprot
Q2PMY2
resolver
uniprot_entry
A0A1L1STF5_MOUSE
resolver
uniprot_entry
IL18_MOUSE
resolver
uniprot_entry
Q2PMY2_MOUSE
resolver
amino_acid_sequence
MAAMSEDSCVNFKEMMFIDNTLYFIPEENGDLESDNFGRLHCTTAVIRNINDQVLFVDKRQPVFEDMTDIDQSASEPQTRLIIYMYKDSEVRGLAVTLSVKDSKMSTLSCKNKIISFEEMDPPENIDDIQSDLIFFQKRVPGHNKMEFESSLYEGHFLACQKEDDAFKLILKKKDENGDKSVMFTLTNLHQS
uniprot
proteins
function
FUNCTION: Pro-inflammatory cytokine primarily involved in epithelial barrier repair, polarized T-helper 1 (Th1) cell and natural killer (NK) cell immune responses (PubMed:26638072, PubMed:26638073). Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators (By similarity). Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells and natural killer (NK) cells (By similarity). Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:30392956). {ECO:0000250|UniProtKB:Q14116, ECO:0000269|PubMed:26638072, ECO:0000269|PubMed:26638073, ECO:0000269|PubMed:30392956}.
uniprot
proteins
mass_dalton
22135
uniprot
proteins
mutagenesis
MUTAGEN 28..31; /note="ENGD->DDEN: Humanized protein that is efficiently cleaved by Casp4/Casp11; when associated with 36-Y--E-41."; /evidence="ECO:0000269|PubMed:37993712"; MUTAGEN 36..41; /note="NFGRLH->YFGRLE: Humanized protein that is efficiently cleaved by Casp4/Casp11; when associated with 28-D--N-41."; /evidence="ECO:0000269|PubMed:37993712
uniprot
proteins
post_translational_modification
PTM: The pro-IL-18 precursor is processed by CASP1 to yield its mature, active form (PubMed:37993712, PubMed:37993714). The pro-IL-18 precursor is however not processed by Casp4/Casp11 in rodents (PubMed:37993712, PubMed:37993714). The pro-IL-18 precursor features autoinhibitory interactions between the propeptide and the post-cleavage-site region, preventing recognition by the IL18R1 receptor (By similarity). Processing by CASP1 induces conformational changes to generate critical receptor-binding sites (By similarity). The mature form is then secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (By similarity). In contrast, cleavage by CASP3 inactivates IL18 (By similarity). {ECO:0000250|UniProtKB:Q14116, ECO:0000269|PubMed:37993712, ECO:0000269|PubMed:37993714}.
uniprot
proteins
protein_family
IL-1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26638072
uniprot
proteins
pubmed
26638073
uniprot
proteins
pubmed
30392956
uniprot
proteins
pubmed
37993712
uniprot
proteins
pubmed
37993714
uniprot
proteins
pubmed
7477296
uniprot
proteins
pubmed
9022080
uniprot
proteins
sequence_length
192
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q14116}. Secreted {ECO:0000269|PubMed:30392956}. Note=The precursor is cytosolic (By similarity). In response to inflammasome-activating signals, cleaved and secreted (By similarity). Mature form is secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore (PubMed:30392956). In contrast, the precursor form is not released, due to the presence of an acidic region that is proteolytically removed by CASP1 during maturation (By similarity). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10 (By similarity). {ECO:0000250|UniProtKB:Q14116, ECO:0000269|PubMed:30392956}.
uniprot
proteins