PDE9A
entrez
5152
canonical
uniprot
O76083
canonical
ensembl
ENSG00000160191
resolver
ensp
ENSP00000291539
resolver
ensp
ENSP00000328699
resolver
ensp
ENSP00000335242
resolver
ensp
ENSP00000335365
resolver
ensp
ENSP00000344730
resolver
ensp
ENSP00000369685
resolver
ensp
ENSP00000381280
resolver
ensp
ENSP00000381281
resolver
ensp
ENSP00000381283
resolver
ensp
ENSP00000381285
resolver
ensp
ENSP00000381287
resolver
ensp
ENSP00000381289
resolver
ensp
ENSP00000381291
resolver
ensp
ENSP00000675241
resolver
genesymbol
PDE9A
resolver
hgnc
HGNC:8795
resolver
uniprot
A0A0S2Z475
resolver
uniprot
A0A0S2Z4A3
resolver
uniprot
A0A0S2Z4T6
resolver
uniprot
B2RBI5
resolver
uniprot
B4DFI5
resolver
uniprot
D3DSJ8
resolver
uniprot
D3DSJ9
resolver
uniprot
O75490
resolver
uniprot
O75491
resolver
uniprot
O95225
resolver
uniprot
Q53Y40
resolver
uniprot
Q5QD39
resolver
uniprot
Q86SF7
resolver
uniprot
Q86SI6
resolver
uniprot
Q86SJ3
resolver
uniprot
Q86WN3
resolver
uniprot
Q86WN4
resolver
uniprot
Q86WN5
resolver
uniprot
Q86WN6
resolver
uniprot
Q86WN7
resolver
uniprot
Q86WN8
resolver
uniprot
Q86WN9
resolver
uniprot
Q86WP0
resolver
uniprot_entry
A0A0S2Z475_HUMAN
resolver
uniprot_entry
A0A0S2Z4A3_HUMAN
resolver
uniprot_entry
A0A0S2Z4T6_HUMAN
resolver
uniprot_entry
PDE9A_HUMAN
resolver
uniprot_sec
B2RBI5
resolver
uniprot_sec
B4DFI5
resolver
uniprot_sec
D3DSJ8
resolver
uniprot_sec
D3DSJ9
resolver
uniprot_sec
O75490
resolver
uniprot_sec
O75491
resolver
uniprot_sec
O95225
resolver
uniprot_sec
Q53Y40
resolver
uniprot_sec
Q5QD39
resolver
uniprot_sec
Q86SF7
resolver
uniprot_sec
Q86SI6
resolver
uniprot_sec
Q86SJ3
resolver
uniprot_sec
Q86WN3
resolver
uniprot_sec
Q86WN4
resolver
uniprot_sec
Q86WN5
resolver
uniprot_sec
Q86WN6
resolver
uniprot_sec
Q86WN7
resolver
uniprot_sec
Q86WN8
resolver
uniprot_sec
Q86WN9
resolver
uniprot_sec
Q86WP0
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by zaprinast; inhibitor is however not specific to PDE9A (PubMed:9624146). Specifically inhibited by BAY-73-6691 (1-(2-chlorophenyl)-6-((2R)-3,3,3- trifluoro-2-methylpropyl)-1,5-dihydro-4H-pyrazolo(3,4-d)pyrimidine-4-one) (PubMed:16150925). BAY-73-9961 has two enantiomers, (R) and (S), due to the presence of a chiral center, and both forms vary in their pattern of interaction (PubMed:20121115, PubMed:21483814). Specifically inhibited by PF-4181366 (4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1- cyclopentyl-1,5-dihydro-6-[(3S,4S)-4-methyl- 1-(6-quinoxalinylmethyl)-3-pyrrolidinyl]-one) (PubMed:19919087). Specifically inhibited by PF-4449613 ((R)-6-(1-(3-phenoxyazetidin-1-yl)ethyl)-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin- 4(5H)-one) (PubMed:25799991). Specifically inhibited by inhibitor 28 (2-((1-(2-Chlorophenyl)-4-hydroxy-1Hpyrazolo[ 3,4-d]pyrimidin-6-yl)amino)-N-(4- methoxyphenyl)propanamide): inhibitor forms a hydrogen bond with Tyr-484 and Gln-513 (PubMed:22985069). Specifically inhibited by 1-Cyclopentyl-6-[(1r)-1-(3-phenoxyazetidin- 1-Yl)ethyl]-1,5-dihydro-4h-pyrazolo[3,4-D] pyrimidin-4-one: inhibitor forms a hydrogen bond with Tyr-484 and Gln-513 (PubMed:23025719). {ECO:0000269|PubMed:16150925, ECO:0000269|PubMed:19919087, ECO:0000269|PubMed:20121115, ECO:0000269|PubMed:21483814, ECO:0000269|PubMed:22985069, ECO:0000269|PubMed:23025719, ECO:0000269|PubMed:25799991, ECO:0000269|PubMed:9624146, ECO:0000303|PubMed:24746902}.
uniprot
proteins
amino_acid_sequence
MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAMVSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRREGAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANHLAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDVPTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
uniprot
proteins
ec_number
3.1.4.35
uniprot
proteins
function
FUNCTION: Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:18757755, PubMed:21483814, PubMed:9624146). Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (By similarity). {ECO:0000250|UniProtKB:Q8QZV1, ECO:0000269|PubMed:18757755, ECO:0000269|PubMed:21483814, ECO:0000269|PubMed:25799991, ECO:0000269|PubMed:9624146, ECO:0000305}.
uniprot
proteins
mass_dalton
68493
uniprot
proteins
mutagenesis
MUTAGEN 312; /note="H->A: Completely abolishes catalytic activity."; /evidence="ECO:0000269|PubMed:18757755"; MUTAGEN 356; /note="H->A: Reduces catalytic activity, but has no effect on substrate affinity."; /evidence="ECO:0000269|PubMed:18757755"; MUTAGEN 425; /note="M->A: Induces a 2 fold change in inhibitory sensitivity by BAY-73-9961."; /evidence="ECO:0000269|PubMed:20121115"; MUTAGEN 463; /note="I->A: Induces a 6-9 fold change in inhibitory sensitivity by BAY-73-9961."; /evidence="ECO:0000269|PubMed:20121115"; MUTAGEN 466; /note="E->A: Decreased affinity and catalytic activity for cGMP and cAMP."; /evidence="ECO:0000269|PubMed:21483814"; MUTAGEN 480; /note="L->A: Induces a 6-9 fold change in inhibitory sensitivity by BAY-73-9961."; /evidence="ECO:0000269|PubMed:20121115"; MUTAGEN 484; /note="Y->A: Induces a 6-9 fold change in inhibitory sensitivity by BAY-73-9961."; /evidence="ECO:0000269|PubMed:20121115"; MUTAGEN 501; /note="F->A: Induces a 2 fold change in inhibitory sensitivity by BAY-73-9961."; /evidence="ECO:0000269|PubMed:20121115"; MUTAGEN 513; /note="Q->A: Induces a dramatic change in inhibitory sensitivity by BAY-73-9961."; /evidence="ECO:0000269|PubMed:20121115"; MUTAGEN 513; /note="Q->E: 2 fold decreased affinity and catalytic activity for cGMP. 8 fold decreased catalytic activity for cAMP without affecting the affinity for cAMP."; /evidence="ECO:0000269|PubMed:21483814"; MUTAGEN 516; /note="F->A: Induces a dramatic change in inhibitory sensitivity by BAY-73-9961."; /evidence="ECO:0000269|PubMed:20121115
uniprot
proteins
pathway_participation
PATHWAY: Purine metabolism; 3',5'-cyclic GMP degradation; GMP from 3',5'-cyclic GMP: step 1/1.
uniprot
proteins
protein_family
Cyclic nucleotide phosphodiesterase family
uniprot
proteins
protein_family
PDE9 subfamily
uniprot
proteins
pubmed
10830953
uniprot
proteins
pubmed
12565835
uniprot
proteins
pubmed
14527714
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15210993
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16150925
uniprot
proteins
pubmed
17090334
uniprot
proteins
pubmed
18757755
uniprot
proteins
pubmed
19919087
uniprot
proteins
pubmed
20121115
uniprot
proteins
pubmed
21483814
uniprot
proteins
pubmed
22328573
uniprot
proteins
pubmed
22985069
uniprot
proteins
pubmed
23025719
uniprot
proteins
pubmed
24746902
uniprot
proteins
pubmed
25799991
uniprot
proteins
pubmed
9624146
uniprot
proteins
pubmed
9856478
uniprot
proteins
sequence_length
593
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform PDE9A1]: Cell projection, ruffle membrane {ECO:0000269|PubMed:17090334}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:17090334}. Golgi apparatus {ECO:0000269|PubMed:17090334}. Endoplasmic reticulum {ECO:0000269|PubMed:17090334}. Cell membrane, sarcolemma {ECO:0000269|PubMed:25799991}.; SUBCELLULAR LOCATION: [Isoform PDE9A2]: Cell projection, ruffle membrane {ECO:0000269|PubMed:17090334}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:17090334}.; SUBCELLULAR LOCATION: [Isoform PDE9A3]: Cytoplasm {ECO:0000269|PubMed:17090334}. Endoplasmic reticulum {ECO:0000269|PubMed:17090334}.; SUBCELLULAR LOCATION: [Isoform PDE9A17]: Cytoplasm {ECO:0000269|PubMed:17090334}. Endoplasmic reticulum {ECO:0000269|PubMed:17090334}.
uniprot
proteins