GPR3
entrez
2827
canonical
uniprot
P46089
canonical
ensembl
ENSG00000181773
resolver
ensp
ENSP00000363136
resolver
ensp
ENSP00000594938
resolver
enst
ENST00000374024
resolver
enst
ENST00000924879
resolver
genesymbol
GPR3
resolver
genesymbol_syn
ACCA
resolver
hgnc
HGNC:4484
resolver
uniprot
A8K570
resolver
uniprot
F1DAM5
resolver
uniprot_entry
F1DAM5_HUMAN
resolver
uniprot_entry
GPR3_HUMAN
resolver
uniprot_sec
A8K570
resolver
activity_regulation
ACTIVITY REGULATION: GPR3 bound to the lipid agonist is in an equilibrium between monomeric and dimeric states. G protein engagement leads to dissociation of the dimer, and efficient coupling and signaling of the G(s) protein. {ECO:0000269|PubMed:40866348}.
uniprot
proteins
amino_acid_sequence
MMWGAGSPLAWLSAGSGNVNVSSVGPAEGPTGPAAPLPSPKAWDVVLCISGTLVSCENALVVAIIVGTPAFRAPMFLLVGSLAVADLLAGLGLVLHFAAVFCIGSAEMSLVLVGVLAMAFTASIGSLLAITVDRYLSLYNALTYYSETTVTRTYVMLALVWGGALGLGLLPVLAWNCLDGLTTCGVVYPLSKNHLVVLAIAFFMVFGIMLQLYAQICRIVCRHAQQIALQRHLLPASHYVATRKGIATLAVVLGAFAACWLPFTVYCLLGDAHSPPLYTYLTLLPATYNSMINPIIYAFRNQDVQKVLWAVCCCCSSSKIPFRSRSPSDV
uniprot
proteins
function
FUNCTION: Constitutively active G protein-coupled receptor that maintains high cAMP levels and contributes to several processes, including meiotic arrest in oocytes and neuronal development, through activation of intracellular signaling pathways. Essential activator of thermogenic adipocytes, where it drives thermogenesis via constitutive G(s)-coupling activity in the absence of ligand (PubMed:34048700). May be activated by lipid-derived agonists such as oleoylethanolamide (OEA), oleic acid or sphingosine 1-phosphate leading to activation of the G(s)/cAMP/PKA signaling pathway (PubMed:12220620, PubMed:38376112, PubMed:38287117). Plays a potential role in modulating brain functions, including behavioral responses to stress and amyloid-beta peptide generation in neurons (By similarity). Stimulates neurite outgrowth in cerebellar granule neurons via PKA, ERK, and PI3K-mediated signaling pathways (By similarity). {ECO:0000250|UniProtKB:P35413, ECO:0000269|PubMed:12220620, ECO:0000269|PubMed:19213921, ECO:0000269|PubMed:34048700, ECO:0000269|PubMed:38287117, ECO:0000269|PubMed:38376112}.
uniprot
proteins
mass_dalton
35010
uniprot
proteins
mutagenesis
MUTAGEN 135; /note="Y->A: Partial loss of constitutive homodimerization."; /evidence="ECO:0000269|PubMed:40866348"; MUTAGEN 211; /note="Q->A: Partial loss of constitutive homodimerization."; /evidence="ECO:0000269|PubMed:40866348"; MUTAGEN 215; /note="Q->A: Partial loss of constitutive homodimerization."; /evidence="ECO:0000269|PubMed:40866348"; MUTAGEN 280; /note="Y->A: Reduced receptor activity."; /evidence="ECO:0000269|PubMed:38287118
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12220620
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19213921
uniprot
proteins
pubmed
19286662
uniprot
proteins
pubmed
34048700
uniprot
proteins
pubmed
38287117
uniprot
proteins
pubmed
38287118
uniprot
proteins
pubmed
38376112
uniprot
proteins
pubmed
40866348
uniprot
proteins
pubmed
7639700
uniprot
proteins
pubmed
7698767
uniprot
proteins
pubmed
7851889
uniprot
proteins
pubmed
8530049
uniprot
proteins
sequence_length
330
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 43..62; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 75..98; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 111..132; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 154..173; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 199..217; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 246..272; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 278..299; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins