MMEL1
entrez
79258
canonical
uniprot
Q495T6
canonical
ensembl
ENSG00000142606
resolver
ensembl
ENSG00000277131
resolver
ensp
ENSP00000367668
resolver
genesymbol
MMEL1
resolver
genesymbol_syn
MELL1
resolver
genesymbol_syn
MMEL2
resolver
genesymbol_syn
NEP2
resolver
hgnc
HGNC:14668
resolver
uniprot
B3KS82
resolver
uniprot
B9DI79
resolver
uniprot
Q495T7
resolver
uniprot
Q495T8
resolver
uniprot
Q5SZS6
resolver
uniprot
Q96PH9
resolver
uniprot_entry
B3KS82_HUMAN
resolver
uniprot_entry
MMEL1_HUMAN
resolver
uniprot_sec
B9DI79
resolver
uniprot_sec
Q495T7
resolver
uniprot_sec
Q495T8
resolver
uniprot_sec
Q5SZS6
resolver
uniprot_sec
Q96PH9
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by thiorphan and phosphoramidon. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MGKSEGPVGMVESAGRAGQKRPGFLEGGLLLLLLLVTAALVALGVLYADRRGKQLPRLASRLCFLQEERTFVKRKPRGIPEAQEVSEVCTTPGCVIAAARILQNMDPTTEPCDDFYQFACGGWLRRHVIPETNSRYSIFDVLRDELEVILKAVLENSTAKDRPAVEKARTLYRSCMNQSVIEKRGSQPLLDILEVVGGWPVAMDRWNETVGLEWELERQLALMNSQFNRRVLIDLFIWNDDQNSSRHIIYIDQPTLGMPSREYYFNGGSNRKVREAYLQFMVSVATLLREDANLPRDSCLVQEDMVQVLELETQLAKATVPQEERHDVIALYHRMGLEELQSQFGLKGFNWTLFIQTVLSSVKIKLLPDEEVVVYGIPYLQNLENIIDTYSARTIQNYLVWRLVLDRIGSLSQRFKDTRVNYRKALFGTMVEEVRWRECVGYVNSNMENAVGSLYVREAFPGDSKSMVRELIDKVRTVFVETLDELGWMDEESKKKAQEKAMSIREQIGHPDYILEEMNRRLDEEYSNLNFSEDLYFENSLQNLKVGAQRSLRKLREKVDPNLWIIGAAVVNAFYSPNRNQIVFPAGILQPPFFSKEQPQALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMMDWWSNFSTQHFREQSECMIYQYGNYSWDLADEQNVNGFNTLGENIADNGGVRQAYKAYLKWMAEGGKDQQLPGLDLTHEQLFFINYAQVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSLQNLAAFADTFHCARGTPMHPKERCRVW
uniprot
proteins
ec_number
3.4.24.11
uniprot
proteins
function
FUNCTION: Metalloprotease involved in sperm function, possibly by modulating the processes of fertilization and early embryonic development. Degrades a broad variety of small peptides with a preference for peptides shorter than 3 kDa containing neutral bulky aliphatic or aromatic amino acid residues. Shares the same substrate specificity with MME and cleaves peptides at the same amide bond (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
89367
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250}.
uniprot
proteins
protein_family
Peptidase M13 family
uniprot
proteins
pubmed
11560781
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
sequence_length
779
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein. Secreted. Note=A secreted form produced by proteolytic cleavage also exists. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 28..48; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins