Cth
entrez
107869
canonical
uniprot
Q8VCN5
canonical
ensembl
ENSMUSG00000028179
resolver
ensp
ENSMUSP00000113672
resolver
ensp
ENSMUSP00000295762
resolver
enst
ENSMUST00000118539
resolver
genesymbol
Cth
resolver
uniprot
Q6H324
resolver
uniprot_entry
CGL_MOUSE
resolver
uniprot_sec
Q6H324
resolver
activity_regulation
ACTIVITY REGULATION: Activated by calmodulin in the presence of calcium ions. {ECO:0000269|PubMed:18948540}.
uniprot
proteins
amino_acid_sequence
MQKDASLSGFLPSFQHFATQAIHVGQEPEQWNSRAVVLPISLATTFKQDFPGQSSGFEYSRSGNPTRNCLEKAVAALDGAKHSLAFASGLAATITITHLLKAGDEIICMDEVYGGTNRYFRRVASEFGLKISFVDCSKTKLLEAAITPQTKLVWIETPTNPTLKLADIGACAQIVHKRGDIILVVDNTFMSAYFQRPLALGADICMCSATKYMNGHSDVVMGLVSVNSDDLNSRLRFLQNSLGAVPSPFDCYLCCRGLKTLQVRMEKHFKNGMAVARFLETNPRVEKVVYPGLPSHPQHELAKRQCSGCPGMVSFYIKGALQHAKAFLKNLKLFTLAESLGGYESLAELPAIMTHASVPEKDRATLGINDTLIRLSVGLEDEQDLLEDLDRALKAAHP
uniprot
proteins
ec_number
4.4.1.1
uniprot
proteins
ec_number
4.4.1.2
uniprot
proteins
function
FUNCTION: Catalyzes the last step in the trans-sulfuration pathway from L-methionine to L-cysteine in a pyridoxal-5'-phosphate (PLP)-dependent manner, which consists on cleaving the L,L-cystathionine molecule into L-cysteine, ammonia and 2-oxobutanoate. Part of the L-cysteine derived from the trans-sulfuration pathway is utilized for biosynthesis of the ubiquitous antioxidant glutathione. Besides its role in the conversion of L-cystathionine into L-cysteine, it utilizes L-cysteine and L-homocysteine as substrates (at much lower rates than L,L-cystathionine) to produce hydrogen sulfide (H2S). In vitro, it converts two L-cysteine molecules into lanthionine and H2S, and two L-homocysteine molecules to homolanthionine and H2S, which can be particularly relevant under conditions of severe hyperhomocysteinemia. Lanthionine and homolanthionine are structural homologs of L,L-cystathionine that differ by the absence or presence of an extra methylene group, respectively (By similarity). Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function (PubMed:19903941, PubMed:22244329). By generating the gasotransmitter H2S, it participates in a number of physiological processes such as vasodilation, bone protection, and inflammation (By similarity) (PubMed:18948540). Plays an essential role in myogenesis by contributing to the biogenesis of H2S in skeletal muscle tissue (PubMed:33826201). Can also accept homoserine as substrate (By similarity). Catalyzes the elimination of selenocystathionine (which can be derived from the diet) to yield selenocysteine, ammonia and 2-oxobutanoate (By similarity). {ECO:0000250|UniProtKB:P18757, ECO:0000250|UniProtKB:P32929, ECO:0000269|PubMed:18948540, ECO:0000269|PubMed:19903941, ECO:0000269|PubMed:22244329, ECO:0000269|PubMed:33826201}.
uniprot
proteins
mass_dalton
43567
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 2/2. {ECO:0000250|UniProtKB:P32929}.
uniprot
proteins
protein_family
Trans-sulfuration enzymes family
uniprot
proteins
pubmed
15038791
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18948540
uniprot
proteins
pubmed
19903941
uniprot
proteins
pubmed
20305127
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22244329
uniprot
proteins
pubmed
33826201
uniprot
proteins
sequence_length
398
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins