Hist1h2an
entrez
319170
canonical
uniprot
C0HKE7
canonical
ensembl
ENSMUSG00000061615
resolver
ensembl
ENSMUSG00000069270
resolver
ensembl
ENSMUSG00000069272
resolver
ensembl
ENSMUSG00000069301
resolver
ensembl
ENSMUSG00000069309
resolver
ensembl
ENSMUSG00000071478
resolver
ensembl
ENSMUSG00000071516
resolver
ensembl
ENSMUSG00000094248
resolver
ensembl
ENSMUSG00000094777
resolver
ensp
ENSMUSP00000077477
resolver
ensp
ENSMUSP00000080088
resolver
ensp
ENSMUSP00000088281
resolver
ensp
ENSMUSP00000088285
resolver
ensp
ENSMUSP00000089335
resolver
ensp
ENSMUSP00000089339
resolver
ensp
ENSMUSP00000089345
resolver
ensp
ENSMUSP00000100034
resolver
ensp
ENSMUSP00000127684
resolver
enst
ENSMUST00000070124
resolver
enst
ENSMUST00000078369
resolver
enst
ENSMUST00000081342
resolver
enst
ENSMUST00000090776
resolver
enst
ENSMUST00000091741
resolver
enst
ENSMUST00000091745
resolver
enst
ENSMUST00000091751
resolver
enst
ENSMUST00000102969
resolver
enst
ENSMUST00000171127
resolver
genesymbol
Hist1h2an
resolver
uniprot
P10812
resolver
uniprot
P22752
resolver
uniprot
Q149U0
resolver
uniprot
Q5SZZ2
resolver
uniprot_entry
H2A1N_MOUSE
resolver
uniprot_sec
P10812
resolver
uniprot_sec
P22752
resolver
uniprot_sec
Q149U0
resolver
uniprot_sec
Q5SZZ2
resolver
amino_acid_sequence
MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLTAEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPKKTESHHKAKGK
uniprot
proteins
function
FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
uniprot
proteins
mass_dalton
14135
uniprot
proteins
post_translational_modification
PTM: Deiminated on Arg-4 in granulocytes upon calcium entry. {ECO:0000250|UniProtKB:P0C0S8}.; PTM: Monoubiquitination of Lys-120 (H2AK119Ub) by RING1, TRIM37 and RNF2/RING2 complex gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. It is involved in the initiation of both imprinted and random X inactivation. Ubiquitinated H2A is enriched in inactive X chromosome chromatin. Ubiquitination of H2A functions downstream of methylation of 'Lys-27' of histone H3 (H3K27me). H2AK119Ub by RNF2/RING2 can also be induced by ultraviolet and may be involved in DNA repair. Following DNA double-strand breaks (DSBs), it is ubiquitinated through 'Lys-63' linkage of ubiquitin moieties by the E2 ligase UBE2N and the E3 ligases RNF8 and RNF168, leading to the recruitment of repair proteins to sites of DNA damage. Ubiquitination at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) in response to DNA damage is initiated by RNF168 that mediates monoubiquitination at these 2 sites, and 'Lys-63'-linked ubiquitin are then conjugated to monoubiquitin; RNF8 is able to extend 'Lys-63'-linked ubiquitin chains in vitro. Deubiquitinated by USP51 at Lys-14 and Lys-16 (H2AK13Ub and H2AK15Ub, respectively) after damaged DNA is repaired (By similarity). H2AK119Ub and ionizing radiation-induced 'Lys-63'-linked ubiquitination (H2AK13Ub and H2AK15Ub) are distinct events. {ECO:0000250|UniProtKB:P0C0S8, ECO:0000269|PubMed:15509584, ECO:0000269|PubMed:15525528, ECO:0000269|PubMed:24352239}.; PTM: Phosphorylation on Ser-2 (H2AS1ph) is enhanced during mitosis. Phosphorylation on Ser-2 by RPS6KA5/MSK1 directly represses transcription. Acetylation of H3 inhibits Ser-2 phosphorylation by RPS6KA5/MSK1. Phosphorylation at Thr-121 (H2AT120ph) by DCAF1 is present in the regulatory region of many tumor suppresor genes and down-regulates their transcription. {ECO:0000250|UniProtKB:P0C0S8, ECO:0000269|PubMed:7217105}.; PTM: Symmetric dimethylation on Arg-4 by the PRDM1/PRMT5 complex may play a crucial role in the germ-cell lineage. {ECO:0000269|PubMed:16699504}.; PTM: Glutamine methylation at Gln-105 (H2AQ104me) by FBL is specifically dedicated to polymerase I. It is present at 35S ribosomal DNA locus and impairs binding of the FACT complex. {ECO:0000269|PubMed:24352239}.; PTM: Crotonylation (Kcr) is specifically present in male germ cells and marks testis-specific genes in post-meiotic cells, including X-linked genes that escape sex chromosome inactivation in haploid cells. Crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors. It is also associated with post-meiotically activated genes on autosomes. {ECO:0000269|PubMed:21925322}.; PTM: Hydroxybutyrylation of histones is induced by starvation. {ECO:0000269|PubMed:27105115}.; PTM: Lactylated in macrophages by EP300/P300 by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription. {ECO:0000250|UniProtKB:P0C0S5}.
uniprot
proteins
protein_family
Histone H2A family
uniprot
proteins
pubmed
12408966
uniprot
proteins
pubmed
15509584
uniprot
proteins
pubmed
15525528
uniprot
proteins
pubmed
16699504
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21925322
uniprot
proteins
pubmed
24352239
uniprot
proteins
pubmed
24681537
uniprot
proteins
pubmed
27105115
uniprot
proteins
pubmed
30154464
uniprot
proteins
pubmed
7217105
uniprot
proteins
sequence_length
130
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Chromosome.
uniprot
proteins