PPP1R16B
entrez
26051
canonical
uniprot
Q96T49
canonical
ensembl
ENSG00000101445
resolver
ensp
ENSP00000299824
resolver
ensp
ENSP00000362428
resolver
genesymbol
PPP1R16B
resolver
genesymbol_syn
ANKRD4
resolver
genesymbol_syn
KIAA0823
resolver
hgnc
HGNC:15850
resolver
uniprot
A2RRR6
resolver
uniprot
E9PFS8
resolver
uniprot
O94912
resolver
uniprot
Q5W9G4
resolver
uniprot
Q9NQG4
resolver
uniprot_entry
PP16B_HUMAN
resolver
uniprot_sec
A2RRR6
resolver
uniprot_sec
E9PFS8
resolver
uniprot_sec
O94912
resolver
uniprot_sec
Q5W9G4
resolver
uniprot_sec
Q9NQG4
resolver
amino_acid_sequence
MASHVDLLTELQLLEKVPTLERLRAAQKRRAQQLKKWAQYEQDLQHRKRKHERKRSTGGRRKKVSFEASVALLEASLRNDAEEVRYFLKNKVSPDLCNEDGLTALHQCCIDNFEEIVKLLLSHGANVNAKDNELWTPLHAAATCGHINLVKILVQYGADLLAVNSDGNMPYDLCEDEPTLDVIETCMAYQGITQEKINEMRVAPEQQMIADIHCMIAAGQDLDWIDAQGATLLHIAGANGYLRAAELLLDHGVRVDVKDWDGWEPLHAAAFWGQMQMAELLVSHGASLSARTSMDEMPIDLCEEEEFKVLLLELKHKHDVIMKSQLRHKSSLSRRTSSAGSRGKVVRRASLSDRTNLYRKEYEGEAILWQRSAAEDQRTSTYNGDIRETRTDQENKDPNPRLEKPVLLSEFPTKIPRGELDMPVENGLRAPVSAYQYALANGDVWKVHEVPDYSMAYGNPGVADATPPWSSYKEQSPQTLLELKRQRAAAKLLSHPFLSTHLGSSMARTGESSSEGKAPLIGGRTSPYSSNGTSVYYTVTSGDPPLLKFKAPIEEMEEKVHGCCRIS
uniprot
proteins
function
FUNCTION: Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function (PubMed:18586956). Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation (PubMed:25007873). Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (By similarity). Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage (By similarity). Involved in the regulation of endothelial cell filopodia extension (By similarity). May be a downstream target for TGF-beta1 signaling cascade in endothelial cells (PubMed:16263087, PubMed:18586956). Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation (PubMed:18586956). Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 (PubMed:16263087). Involved in the dephosphorylation of EEF1A1 (PubMed:26497934). {ECO:0000250|UniProtKB:Q8VHQ3, ECO:0000250|UniProtKB:Q95N27, ECO:0000269|PubMed:16263087, ECO:0000269|PubMed:18586956, ECO:0000269|PubMed:25007873, ECO:0000269|PubMed:26497934}.
uniprot
proteins
mass_dalton
63551
uniprot
proteins
mutagenesis
MUTAGEN 252; /note="G->A: Strongly decreased interaction with EEF1A1."; /evidence="ECO:0000269|PubMed:26497934
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKA and, after PKA priming, by GSK3B. Phosphorylation by GSK3B reduces its association with PP1C and enhances PP1C activity. Dephosphorylation by its associated PP1C results in enhanced association with PP1C, but reduced PP1C activity (By similarity). {ECO:0000250|UniProtKB:Q95N27}.
uniprot
proteins
pubmed
10048485
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12055102
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15491607
uniprot
proteins
pubmed
16263087
uniprot
proteins
pubmed
18586956
uniprot
proteins
pubmed
21907835
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25007873
uniprot
proteins
pubmed
26497934
uniprot
proteins
sequence_length
567
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18586956, ECO:0000269|PubMed:26497934}. Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Nucleus {ECO:0000269|PubMed:18586956}. Cell projection {ECO:0000269|PubMed:25007873}. Note=Colocalizes with RPSA/LAMR1 in the cell membrane (PubMed:16263087). Localizes to the perinuclear region (By similarity). Colocalizes with PTEN at the tip of EC projections (PubMed:25007873). {ECO:0000250|UniProtKB:Q95N27, ECO:0000269|PubMed:16263087, ECO:0000269|PubMed:25007873}.
uniprot
proteins