PHF19
entrez
26147
canonical
uniprot
Q5T6S3
canonical
ensembl
ENSG00000119403
resolver
ensp
ENSP00000310372
resolver
ensp
ENSP00000363003
resolver
ensp
ENSP00000397935
resolver
ensp
ENSP00000407433
resolver
ensp
ENSP00000483946
resolver
ensp
ENSP00000750648
resolver
ensp
ENSP00000750649
resolver
enst
ENST00000419155
resolver
enst
ENST00000616568
resolver
genesymbol
PHF19
resolver
genesymbol_syn
PCL3
resolver
hgnc
HGNC:24566
resolver
uniprot
A0A087X169
resolver
uniprot
B7Z887
resolver
uniprot
B7Z8H3
resolver
uniprot
F5H8K3
resolver
uniprot
Q32NF2
resolver
uniprot
Q5T6S4
resolver
uniprot
Q6N038
resolver
uniprot
Q8TBL6
resolver
uniprot
Q9UFS9
resolver
uniprot_entry
A0A087X169_HUMAN
resolver
uniprot_entry
B7Z887_HUMAN
resolver
uniprot_entry
B7Z8H3_HUMAN
resolver
uniprot_entry
F5H8K3_HUMAN
resolver
uniprot_entry
PHF19_HUMAN
resolver
uniprot_sec
Q32NF2
resolver
uniprot_sec
Q5T6S4
resolver
uniprot_sec
Q6N038
resolver
uniprot_sec
Q8TBL6
resolver
uniprot_sec
Q9UFS9
resolver
amino_acid_sequence
MENRALDPGTRDSYGATSHLPNKGALAKVKNNFKDLMSKLTEGQYVLCRWTDGLYYLGKIKRVSSSKQSCLVTFEDNSKYWVLWKDIQHAGVPGEEPKCNICLGKTSGPLNEILICGKCGLGYHQQCHIPIAGSADQPLLTPWFCRRCIFALAVRKGGALKKGAIARTLQAVKMVLSYQPEELEWDSPHRTNQQQCYCYCGGPGEWYLRMLQCYRCRQWFHEACTQCLNEPMMFGDRFYLFFCSVCNQGPEYIERLPLRWVDVVHLALYNLGVQSKKKYFDFEEILAFVNHHWELLQLGKLTSTPVTDRGPHLLNALNSYKSRFLCGKEIKKKKCIFRLRIRVPPNPPGKLLPDKGLLPNENSASSELRKRGKSKPGLLPHEFQQQKRRVYRRKRSKFLLEDAIPSSDFTSAWSTNHHLASIFDFTLDEIQSLKSASSGQTFFSDVDSTDAASTSGSASTSLSYDSRWTVGSRKRKLAAKAYMPLRAKRWAAELDGRCPSDSSAEGASVPERPDEGIDSHTFESISEDDSSLSHLKSSITNYFGAAGRLACGEKYQVLARRVTPEGKVQYLVEWEGTTPY
uniprot
proteins
function
FUNCTION: Polycomb group (PcG) protein that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex, thus enhancing PRC2 H3K27me3 methylation activity (PubMed:15563832, PubMed:18691976, PubMed:23104054, PubMed:23160351, PubMed:23228662, PubMed:23273982, PubMed:29499137, PubMed:31959557). Probably involved in the transition from an active state to a repressed state in embryonic stem cells: acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting H3K36me3 histone demethylases RIOX1 or KDM2B, leading to demethylation of H3K36 and recruitment of the PRC2 complex that mediates H3K27me3 methylation, followed by de novo silencing (PubMed:23160351). Recruits the PRC2 complex to CpG islands and contributes to embryonic stem cell self-renewal. Also binds histone H3 dimethylated at 'Lys-36' (H3K36me2) (PubMed:23104054). Isoform 1 and isoform 2 inhibit transcription from an HSV-tk promoter (PubMed:15563832). {ECO:0000269|PubMed:15563832, ECO:0000269|PubMed:18691976, ECO:0000269|PubMed:23104054, ECO:0000269|PubMed:23160351, ECO:0000269|PubMed:23228662, ECO:0000269|PubMed:23273982, ECO:0000269|PubMed:29499137, ECO:0000269|PubMed:31959557}.
uniprot
proteins
mass_dalton
65591
uniprot
proteins
mutagenesis
MUTAGEN 50; /note="W->A: In muthPhf19; abolishes histone H3K36me3-binding and impaired activity of the PRC2 complex and subsequent H3K27me3 methylation."; /evidence="ECO:0000269|PubMed:23104054, ECO:0000269|PubMed:23160351"; MUTAGEN 50; /note="W->C: Abolishes histone H3K36me3-binding and recruitment of the PRC2 complex and RIOX1; when associated with A-56."; /evidence="ECO:0000269|PubMed:23104054, ECO:0000269|PubMed:23160351"; MUTAGEN 56; /note="Y->A: Abolishes histone H3K36me3-binding. Abolishes histone H3K36me3-binding and recruitment of the PRC2 complex and RIOX1; when associated with C-50."; /evidence="ECO:0000269|PubMed:23160351, ECO:0000269|PubMed:23273982"; MUTAGEN 331..332; /note="KK->AA: Impairs chromatin binding as part of the PRC2 complex."; /evidence="ECO:0000269|PubMed:31959557
uniprot
proteins
protein_family
Polycomblike family
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15563832
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
21143197
uniprot
proteins
pubmed
22487681
uniprot
proteins
pubmed
23104054
uniprot
proteins
pubmed
23160351
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23228662
uniprot
proteins
pubmed
23273982
uniprot
proteins
pubmed
29499137
uniprot
proteins
pubmed
31959557
uniprot
proteins
sequence_length
580
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15563832, ECO:0000269|PubMed:31959557}. Note=Localizes to chromatin as part of the PRC2 complex. {ECO:0000269|PubMed:31959557}.
uniprot
proteins