Q69Z23
uniprot
Q69Z23
canonical
amino_acid_sequence
MPDLRIDYLETVSSVLLKFKADKWGKLIGAEENMALLTEFFDKIDNPVLVLTLNAAGMIIPCLGFPESLKSKGVYFIKMKPENITKDNYKTHLIYGDISPTTVDQLIAVVEEVLYSLLNQSENMDGWPRVVSEDIVKQVHRLKNEMFVMGGKIKGKTLLPIPEHLGSLDGTLDSMERIPSSMDNSLLHSIETIIIDWSHQIRDVLSKDSAQALLDGLHPLPRVEFEFWDARLMNLQCIHEQLNRPKVNKIVEILEKAKSCYWPALQNVYMNVTQGLKEANGIVLYLKPLRILLEEMEQADFTMLPSFIVKVLSTICFIWATSEHYNTPSRVIVILREFCNQIIEMTRTYLSPDEVLKGLQGEIEEVLGNISLSVSVLKGLFQAYDFCCANMKLFFKDRPPVPWEFPSSLAFSRMNSFFHRVQTIEDLYKTAIEFLKLEKIELGGVWGNILGNLVTQIYDEVFELVKVFAECKYDPLDPGDSSFDDDYSDFETKIQDLDRRLATIFCQAFDDCNCMESSAKLLYMCGGLLERPLILVEVVPRYSVMLEMFNTELDNAKLMYDAQMAASADGQIPPIHKNMSPVSGQLKWSLELQERLEVSMKYLKHIEHPVMSSMEAKLIYDKYDEMMGLLQSCRMKKYQQWVEGVDQDCHFNLGQPLIQRDPFTSLIQVNFSKALVAVLREVKYLNFQQQKEIPESAEKLFSENETFRKFVGNLELIVGWYNEIKTTVKDVEFPLIKSELEAIDVKLLSAETTLFWNGENVMEYIQEMREMLYNLQNRIQKAKQNVEGITQAMQEWSANPLFERKDNKKEALLDLDGRVANLNKRYAAVKEAGVRIQAMVVENAELFRADTTSQSWKDYVNYIDTVVLDEFDRFIRKSLNYLMDNMTMDESIAPLFEIRMELDKDGLTYNPSLEMGDEAGFLSLIEGLINDLYNVARLIPRLAKGRLNYKSDLEDITDLIEMREEVSSLVIGAMKVAEEYQDSFERYSYLWVDDLQEFMKNFLIFGHAPTPEELDTKTDDTIPKTPPTLAQFQQQIDSYEKLYEEVSSCENTKVFHGWLQCDCRPFKQTLLNTIKRWSFLFKRYLNNHVINSLADLESFMNITRTALKKPLKEGDYDGLVEVMGHLMKVKERQVATDSMFEPLKQTIELLKSYGEEMPEEIYLKLQELPEQWTNTKKLAIQVKQNVAPLQANEVNILRRKCQQFELKQHEFREKFRRDAPFSFSDPEPYKSLNKIYLLYGVMEALCKSASLFEVTVPDYKQLKACHREVRLLKELWDMIVMVNTSIDDWKTTKWKDINVEQMDIDCKKFAKDVRSLDKEMKPWDAFVGLDNTVKNMITSLRAVSELQNPAIRDRHWQQLMQATQVKFEMSEETTLADLLQLNLHKYEDEVRNIVDKAVKESGMEKVLKTLDITWTTMEFEHELHPRTGTMMLKSDEVLVETLEDNQVQLQNLMMSKYLSHFLKEVTSWQQKLSTADSVISIWFEVQRTWSHLESIFIGSEDIRAQLPEDSKRFDAIDQEFKALMEDAVKTPNVVEATNKPDLYNKLENLKMSLAVCEKALAEYLETKRLAFPRFYFVSSADLLDILSNGNDPVEVSRHLSKLFDSLCKLKFRLDASGKPLKFGLGMYSKEDEFVDFDKECDLSGQVEVWLNRVLDRMRATLRHEIPEAVVTYEEKPREQWIFDYPAQIWWTTEVGLAFARLEEGYENAIKDYNKKQISQLNALITLLIGNLTAGDRMKIMTICTIDVHARDVVAKMITVESSQAFTWQSQLRHRWDEEKKHCFANICDAQIKYSYEYLGNTPRLVITPLTDRCYITLTQSLHLIMGGAPAGPAGTGKTETTKDLGRALGTMVYVFNCSEQMDYKSCGNIYKGLAQTGAWGCFDEFNRISVEVLSVIAVQVKCVQDAIRAKKKKFNFLGEIISLVPTVGIFITMNPGYAGRTELPENLKALFRPCAMVVPDFELICEIMLVAEGFLDARLLARKFITLYTLCKELLSKQDHYDWGLRAIKSVLVVAGSLKRGDPTRAEDQVLMRALRDFNIPKIVTDDLPVFMGLIGDLFPALDVPRKRDLNFEKIIKQSIVELKLQAEDSFVLKVVQLEELLQVRHSVFVIGNAGSGKSQVLKSLNKTYQNLKRKPVAVDLDPKAVTCDELFGIINPATREWKDGLFSTIMRDLANLTHEGPKWIVLDGDIDPMWIESLNTVMDDNKVLTLASNERIPLNRTMRLVFEISHLRTATPATVSRAGILYINPADLGWNPVVSSWIERRKVQSEKANLIILFDKYLPTCLDKLRIGFKRITPVPEITVIQTILYLLECLLTEKNAPPDSPKELYELYFVFACFWAFGGAMFQDQLIDYRVEFSKWWINEFKTIKLPSQGTIFDYYIDPETKKFLPWTDKVPNFELDPDIPLQASLVHTTETIRIRYFIDLLMEKAWPVMLVGNAGTGKSVLMGDKLENLSTDDYLVQAVPFNFYTTSAMLQGVLEKPLEKKSGRNYGPPGTKKLIYFIDDMNMPEVDKYGTVAPHTLIRQHMDHRHWYDRQKLTLKDVHNCQYVACMNPTSGSFTIDPRLQRHFCVFAVSFPGQEALTSIYNTILAQHLSFRSAPLVIQRLSSHLVTAALALHQKVSATFLPTAIKFHYIFNLRDLSNIFQGILFSTAEILKTPLDLVRLWLHEAERVYGDKMVDEKDQETLHRVTIASVKKFFDDLGEENLFAKPNIFCHFTQGIGDPKYFPVTDVAQLNKLLKDVLDSYNEVNAVMNLVLFEDAVAHICKINRILESPRGNALLVGVGGSGKQSLSRLAAYISALDVFQITLKKGYAIPDLKMDLATQYIKSAVKNVPSVFLMTDSQVAEEQFLVLINDLLASGEIPGLFGDEDLENIISSMRPQVKSLGIADTREACWKFFIEKVRRQLKVILCFSPVGSVLRVRARKFPAVVNCTAINWFHEWPEDALVSVSARFLEETEGIEPEVKTSISLFMAYVHTTVNEMSKIYLTIERRYNYTTPKTFLEQIKLYQNLLAKKRMELVAKIERLENGLMKLQSTASQVDDLKAKLAVQETELKQKNENADKLIQVVGVETEKVSKEKAIADEEEMKVEVINKNVTEKQKACETDLAKAEPALLAAQEALDTLNKNNLTELKSFGSPPDAVVNVTAAVMILTAPGGKIPKDKSWKAAKIMMGKVDTFLDSLKKFDKEHIPEACLKAFKPYQGNPTFDPEFIRSKSTAAAGLCSWCINIVRFYEVYCDVAPKRQALEEANAELAEAQEKLSRIKNKIAELNANLSNLTSAFEKATAEKIKCQQEADATNRVISLANRLVGGLASENVRWAESVENFKSQGVTLCGDVLLISAFVSYVGYFTKKYRNELMEKFWIPYINKLKVPIPITEGLDPLTLLTDDADVATWNNQGLPSDRMSTENATILCNTERWPLIVDAQLQGIKWIKNKYGSDLQAIRLGQKSYLDIIEQAISAGDTLLIENIGETVDPVLDPLLGRNTIKKGRFIKIGDKEVEYHPSFRLILHTKYFNPHYKPEMQAQCTLINFLVTRDGLEDQLLAAVVAKERPDLEQLKANLTKSQNEFKIVLKELEDSLLARLSAASGNFLGDTALVENLETTKHTANEIEEKVQEAKITEVKINEARENYRPAAERASLLYFILNDLNKINPIYQFSLKAFNVVFEKAIQKTAPADEVKQRVINLTDEITYSVYMYTARGLFERDKLIFLAQVTFQVLSMKKELNPVELDFLLRFPFKAGVVSPVDFLQHQSWGGIKALSEMDEFKNLDSDIEGSAKRWKKLVESEAPEKEIFPKEWKNKTALQKLCMVRCMRPDRMTYAVKNFVEEKMGSKFVEGRSVEFSKSYKESSPSTPIFFILSPGVDPLKDVEALGKKLGFTIDNGKLHNVSLGQGQEVVAENALDVAAEKGHWVILQVRGSLPQNIHLVARWLGILDKKVERYSSGSHEDYRVFISAEPAPTAETHIIPQGILENAIKITNEPPTGMYANLHKALDLFTQDTLEMCTKEIEFKCILFALCYFHAVVAERRKFGAQGWNRSYPFNNGDLTISINVLYNYLEANSKVPWDDLRYLFGEIMYGGHITDDWDRRLCRTYLAEYIRVEMLEGEVLLAPGFQIPPNLDYKGYHEYIDENLPPESPYLYGLHPNAEIGFLTVTSEKLFRTVLEMQPKETDSGAGTGVSREEKVGAVPVPEGSLGSEGSLGTIGLPGTGFQVKAVLDDILEKIPETFNMAEIMAKAAEKTPYVVVAFQECERMNILTNEMRRSLKELNLGLKGELTITTDMEDLSTALFYDTVPDTWVARAYPSMMGLAAWYADLLQRIRELESWTTDFALPTTVWLAGFFNPQSFLTAIMQSMARKNEWPLDKMCLSVEVTKKNREDMTAPPREGSYVYGLFMEGARWDTQTGVIAEARLKDLTPVMPVIFIKAIPVDRMETKNIYECPVYKTRIRGPTYVWTFNLKTKEKAAKWILAAVALLLQV
uniprot
proteins
function
FUNCTION: Force generating protein component of the outer dynein arms (ODAs) in the sperm flagellum (By similarity). Produces force towards the minus ends of microtubules (By similarity). Key component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). Required for structural and functional integrity of cilia (By similarity). Plays a major role in sperm motility, implicated in sperm flagellar assembly and beating (By similarity). {ECO:0000250|UniProtKB:I7M9J2, ECO:0000250|UniProtKB:Q9NYC9, ECO:0000250|UniProtKB:Q9UFH2}.
uniprot
proteins
mass_dalton
511603
uniprot
proteins
protein_family
Dynein heavy chain family
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
39503742
uniprot
proteins
pubmed
9373155
uniprot
proteins
sequence_length
4481
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q9UFH2}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:39503742}.
uniprot
proteins