Fgf1
entrez
14164
canonical
uniprot
P61148
canonical
ensembl
ENSMUSG00000036585
resolver
ensp
ENSMUSP00000045710
resolver
ensp
ENSMUSP00000111245
resolver
ensp
ENSMUSP00000123293
resolver
ensp
ENSMUSP00000157968
resolver
ensp
ENSMUSP00000275052
resolver
ensp
ENSMUSP00000275054
resolver
ensp
ENSMUSP00000275055
resolver
ensp
ENSMUSP00000275058
resolver
ensp
ENSMUSP00000275061
resolver
ensp
ENSMUSP00000275062
resolver
ensp
ENSMUSP00000275063
resolver
enst
ENSMUST00000040647
resolver
enst
ENSMUST00000115582
resolver
enst
ENSMUST00000131348
resolver
enst
ENSMUST00000236630
resolver
genesymbol
Fgf1
resolver
genesymbol_syn
Fgf-1
resolver
genesymbol_syn
Fgfa
resolver
uniprot
D6RCX9
resolver
uniprot
P10935
resolver
uniprot
Q6ZWS1
resolver
uniprot_entry
D6RCX9_MOUSE
resolver
uniprot_entry
FGF1_MOUSE
resolver
uniprot_entry
Q6ZWS1_MOUSE
resolver
uniprot_sec
P10935
resolver
amino_acid_sequence
MAEGEITTFAALTERFNLPLGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDQHIQLQLSAESAGEVYIKGTETGQYLAMDTEGLLYGSQTPNEECLFLERLEENHYNTYTSKKHAEKNWFVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD
uniprot
proteins
function
FUNCTION: Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis. {ECO:0000250|UniProtKB:P05230}.
uniprot
proteins
mass_dalton
17418
uniprot
proteins
post_translational_modification
PTM: In the nucleus, phosphorylated by PKC/PRKCD. {ECO:0000250}.
uniprot
proteins
protein_family
Heparin-binding growth factors family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2318343
uniprot
proteins
pubmed
8939980
uniprot
proteins
pubmed
8972905
uniprot
proteins
sequence_length
155
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted. Cytoplasm {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1. Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59 (By similarity). {ECO:0000250}.
uniprot
proteins