Fer
entrez
301737
canonical
uniprot
P09760
canonical
ensembl
ENSRNOG00000015898
resolver
ensembl
ENSRNOG00055019698
resolver
ensembl
ENSRNOG00060001617
resolver
ensembl
ENSRNOG00065019079
resolver
ensp
ENSRNOP00000090379
resolver
ensp
ENSRNOP00000095206
resolver
ensp
ENSRNOP00055027310
resolver
ensp
ENSRNOP00060001616
resolver
ensp
ENSRNOP00065025665
resolver
enst
ENSRNOT00000097737
resolver
enst
ENSRNOT00000112759
resolver
enst
ENSRNOT00055033660
resolver
enst
ENSRNOT00060002493
resolver
enst
ENSRNOT00065032154
resolver
genesymbol
Fer
resolver
genesymbol_syn
Fert2
resolver
genesymbol_syn
Flk
resolver
uniprot
A0A8I6ANB7
resolver
uniprot
F1MA12
resolver
uniprot_entry
A0A8I6ANB7_RAT
resolver
uniprot_entry
FER_RAT
resolver
uniprot_sec
F1MA12
resolver
amino_acid_sequence
MGFGSDLKNSQEAVLKLQDWELRLLETVKKFMALRIKSDKEYAYTLQNLCNQVDKDSTVQVNYVSNVSKSWLLMIQQTEQLSRIMKTHAEDLNSGPLHRLTMMIKDKQQVKKSYVGIHQQIEAEMIKVTKTELEKLKSSYRQLIKEMNSAKEKYKEALAKGKETEKAKERCDKATMKLHMLHNQYVLALKGAQLHQSQYYDTTLPLLLDSVQKMQEEMIKALKGIFDEYSEITSLVTEEIVNVHKEIQMSVDQIDPSTEYNDFIDVHRTTAAKEQEIEFDTSLLEENENLQANEIMWNNLTADSLQVMLKTLAEELTQTQQMLLHKEAAVLELEKRIEESSETCAKKSDIVLLLGQKQALEELKQSVQQLRCTEAKCAAQKELLEQKVQENDGKEPPPVVNYEEDARSVTSMERKERLSKFESIRHSIAGIIKSPKSVLGSSTQLSDVISVGEKPLAEHDWYHGAIPRIEAQELLKQQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQFVDNLYRFEGTGFSNIPQLIDHHFNTKQVITKKSGVVLLNPIPKDKKWVLNHEDVSLGELLGKGNFGEVYKGTLKDKTPVAVKTCKEDLPQELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVPGGDFLSFLRKRKDELKLKQLVRFSLDVAAGMLYLEGKNCIHRDLAARNCLVGENNTLKISDFGMSRQEDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQNCPEEIFTIMMKCWDYKPENRPKFSDLHKELTAIKKKIT
uniprot
proteins
ec_number
2.7.10.2
uniprot
proteins
function
FUNCTION: Tyrosine-protein kinase that acts downstream of cell surface receptors for growth factors and plays a role in the regulation of the actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. Acts downstream of EGFR, KIT, PDGFRA and PDGFRB. Acts downstream of EGFR to promote activation of NF-kappa-B and cell proliferation. May play a role in the regulation of the mitotic cell cycle. Plays a role in the insulin receptor signaling pathway and in activation of phosphatidylinositol 3-kinase. Acts downstream of the activated FCER1 receptor and plays a role in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. Plays a role in the regulation of mast cell degranulation. Plays a role in leukocyte recruitment and diapedesis in response to bacterial lipopolysaccharide (LPS). Plays a role in neuronal cell death after brain damage. Phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1 and PTPN11. May phosphorylate JUP and PTPN1. Can phosphorylate STAT3, but the biological relevance of this clearly depends on cell type and stimulus (By similarity). Plays a role in synapse organization, trafficking of synaptic vesicles, the generation of excitatory postsynaptic currents and neuron-neuron synaptic transmission. {ECO:0000250, ECO:0000269|PubMed:19047464}.
uniprot
proteins
mass_dalton
94314
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. {ECO:0000250}.; PTM: Polyubiquitinated; this leads to proteasomal degradation. {ECO:0000250}.
uniprot
proteins
protein_family
Fes/fps subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
19047464
uniprot
proteins
pubmed
21122136
uniprot
proteins
pubmed
2485255
uniprot
proteins
sequence_length
823
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cell projection {ECO:0000250}. Cell junction {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Note=Associated with the chromatin. Detected on microtubules in polarized and motile vascular endothelial cells. Colocalizes with F-actin at the cell cortex. Colocalizes with PECAM1 and CTNND1 at nascent cell-cell contacts (By similarity). {ECO:0000250}.
uniprot
proteins