GZMH
entrez
2999
canonical
uniprot
P20718
canonical
ensembl
ENSG00000100450
resolver
ensp
ENSP00000216338
resolver
ensp
ENSP00000371988
resolver
ensp
ENSP00000547912
resolver
genesymbol
GZMH
resolver
genesymbol_syn
CGL2
resolver
genesymbol_syn
CTSGL2
resolver
hgnc
HGNC:4710
resolver
uniprot
G3V2C5
resolver
uniprot
Q6XGZ0
resolver
uniprot
Q6XGZ1
resolver
uniprot_entry
GRAH_HUMAN
resolver
uniprot_sec
G3V2C5
resolver
uniprot_sec
Q6XGZ0
resolver
uniprot_sec
Q6XGZ1
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by SERPINB1. {ECO:0000269|PubMed:23269243}.
uniprot
proteins
amino_acid_sequence
MQPFLLLLAFLLTPGAGTEEIIGGHEAKPHSRPYMAFVQFLQEKSRKRCGGILVRKDFVLTAAHCQGSSINVTLGAHNIKEQERTQQFIPVKRPIPHPAYNPKNFSNDIMLLQLERKAKWTTAVRPLRLPSSKAQVKPGQLCSVAGWGYVSMSTLATTLQEVLLTVQKDCQCERLFHGNYSRATEICVGDPKKTQTGFKGDSGGPLVCKDVAQGILSYGNKKGTPPGVYIKVSHFLPWIKRTMKRL
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication. {ECO:0000269|PubMed:22156497, ECO:0000269|PubMed:23269243}.
uniprot
proteins
mass_dalton
27315
uniprot
proteins
protein_family
Granzyme subfamily
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2049336
uniprot
proteins
pubmed
2193684
uniprot
proteins
pubmed
22156497
uniprot
proteins
pubmed
23269243
uniprot
proteins
pubmed
2402757
uniprot
proteins
sequence_length
246
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytolytic granule {ECO:0000269|PubMed:23269243}.
uniprot
proteins