Olig1
entrez
50914
canonical
uniprot
Q9JKN5
canonical
ensembl
ENSMUSG00000046160
resolver
ensp
ENSMUSP00000061408
resolver
enst
ENSMUST00000056882
resolver
genesymbol
Olig1
resolver
uniprot
Q3UN59
resolver
uniprot_entry
OLIG1_MOUSE
resolver
uniprot_entry
Q3UN59_MOUSE
resolver
amino_acid_sequence
MYYAISQARVNAAPATMLRPQRPGDVQLGASLYELVGYRQPPISSSSSSSSSTASLLPKPAREKAEAPLAEPRGPAPESGGARADAKEEQQQQQLRRKINSRERKRMQDLNLAMDALREVILPYSAAHCQGAPGRKLSKIATLLLARNYILLLGSSLQELRRALGDGAGPAAPRLLLAGLPLLAAAPGSVLLAPGAVGPPETLRPTKYLSLALDEPPCGQFSLPAGGAGSPGLCSCAVCKFPHLVPAGLGLAAVQAQFSK
uniprot
proteins
function
FUNCTION: Orchestrates progenitor cell fates during cortical gliogenesis and gliomagenesis. In cooperation with OLIG2, activates oligodendrocyte precursor cells (OPCs) formation while repressing the generation of olfactory bulb interneuron intermediate progenitors (OBIN) through transcriptional regulation of GSX2. Mechanistically, binds and silences multiple conserved enhancer elements of GSX2. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube. {ECO:0000269|PubMed:11955448, ECO:0000269|PubMed:41193423}.; FUNCTION: Promotes formation and maturation of oligodendrocytes, especially within the brain. Cooperates with OLIG2 to establish the pMN domain of the embryonic neural tube. {ECO:0000269|PubMed:11955448}.
uniprot
proteins
mass_dalton
27141
uniprot
proteins
post_translational_modification
PTM: 'Lys-63'-linked polyubiquitinated by RNF220; leading to stabilization during oligodendroglial development and myelination. {ECO:0000250|UniProtKB:Q8TAK6}.
uniprot
proteins
pubmed
10719888
uniprot
proteins
pubmed
10719889
uniprot
proteins
pubmed
11091082
uniprot
proteins
pubmed
11955448
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
41193423
uniprot
proteins
sequence_length
260
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
uniprot
proteins