Mcm4
entrez
17217
canonical
uniprot
P49717
canonical
ensembl
ENSMUSG00000022673
resolver
ensp
ENSMUSP00000023353
resolver
enst
ENSMUST00000023353
resolver
genesymbol
Mcm4
resolver
genesymbol_syn
Cdc21
resolver
genesymbol_syn
Mcmd4
resolver
uniprot
O89056
resolver
uniprot
Q3UA65
resolver
uniprot
Q542F4
resolver
uniprot_entry
MCM4_MOUSE
resolver
uniprot_entry
Q3UA65_MOUSE
resolver
uniprot_entry
Q542F4_MOUSE
resolver
uniprot_sec
O89056
resolver
amino_acid_sequence
MSSPASTPSRRSSRRGRVTPTQSLRSEESRSSPNRRRRGEDSSTGELLPMPTSPGADLQSPPAQNALFSSPPQMHSLAIPLDFDVSSPLTYGTPSSRVEGTPRSGVRGTPVRQRPDLGSARKGLQVDLQSDGAAAEDIVPSEQSLGQKLVIWGTDVNVATCKENFQRFLQCFTDPLAKEEENVGIDITQPLYMQQLGEINITGEPFLNVNCEHIKSFSKNLYRQLISYPQEVIPTFDMAVNEIFFDRYPDSILEHQIQVRPFNALKTKSMRNLNPEDIDQLITISGMVIRTSQLIPEMQEAFFQCQVCAHTTRVEIDRGRIAEPCSCVHCHTTHSMALIHNRSFFSDKQMIKLQESPEDMPAGQTPHTIVLFAHNDLVDKVQPGDRVNVTGIYRAVPIRVNPRVSNVKSVYKTHIDVIHYRKTDAKRLHGLDEEAEQKLFSEKRVKLLKELSRKPDIYERLASALAPSIYEHEDIKKGILLQLFGGTRKDFSHTGRGKFRAEINILLCGDPGTSKSQLLQYVYNLVPRGQYTSGKGSSAVGLTAYVMKDPETRQLVLQTGALVLSDNGICCIDEFDKMNESTRSVLHEVMEQQTLSIAKAGIICQLNARTSVLAAANPIESQWNPKKTTIENIQLPHTLLSRFDLIFLMLDPQDEAYDRRLAHHLVSLYYQSEEQVEEEFLDMAVLKDYIAYAHSTIMPRLSEEASQALIEAYVNMRKIGSSRGMVSAYPRQLESLIRLAEAHAKVRFSNKVEAIDVEEAKRLHREALKQSATDPRTGIVDISILTTGMSATSRKRKEELAEALRKLILSKGKTPALKYQQLFEDIRGQSDTAITKDMFEEALRALADDDFLTVTGKTVRLL
uniprot
proteins
ec_number
3.6.4.12
uniprot
proteins
function
FUNCTION: Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. {ECO:0000269|PubMed:12207017}.
uniprot
proteins
mass_dalton
96736
uniprot
proteins
mutagenesis
MUTAGEN 305..308; /note="CQVC->AQVA: Results in unstable hexamers. Increased MCM complex DNA helicase activity."; /evidence="ECO:0000269|PubMed:12207017"; MUTAGEN 327..330; /note="CVHC->AVHA: Results in unstable hexamers. Increased MCM complex DNA helicase activity."; /evidence="ECO:0000269|PubMed:12207017"; MUTAGEN 573..574; /note="DE->AA: Decreased MCM complex DNA helicase activity. Reduced ssDNA binding. No effect on MCM complex formation. No effect on MCM complex ATP binding and ATPase activity."; /evidence="ECO:0000269|PubMed:10567526
uniprot
proteins
post_translational_modification
PTM: Sumoylated; SUMO2 modified in response to stress caused by inhibition of proteasome activity (in vitro). {ECO:0000269|PubMed:26524493}.
uniprot
proteins
protein_family
MCM family
uniprot
proteins
pubmed
10567526
uniprot
proteins
pubmed
12207017
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
26524493
uniprot
proteins
pubmed
7610039
uniprot
proteins
pubmed
9798653
uniprot
proteins
sequence_length
862
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P30664}. Chromosome {ECO:0000250|UniProtKB:P30664}. Note=Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. {ECO:0000250|UniProtKB:P30664}.
uniprot
proteins