Aste1
entrez
66595
canonical
uniprot
Q8BIR2
canonical
ensembl
ENSMUSG00000032567
resolver
ensp
ENSMUSP00000035181
resolver
ensp
ENSMUSP00000131164
resolver
ensp
ENSMUSP00000149596
resolver
ensp
ENSMUSP00000244464
resolver
enst
ENSMUST00000167674
resolver
genesymbol
Aste1
resolver
uniprot
E9Q1A4
resolver
uniprot
Q4KMN1
resolver
uniprot
Q80VC2
resolver
uniprot_entry
ASTE1_MOUSE
resolver
uniprot_entry
E9Q1A4_MOUSE
resolver
uniprot_sec
Q4KMN1
resolver
uniprot_sec
Q80VC2
resolver
amino_acid_sequence
MGIRGLMSFVEDYSNEFFVDLKLRNTKLIIDGYSLFHRLCFNSDLELRYGGDYDLFADVVQKFFESLFVCHICPYVVLDGGCDISDKKLTTLKDRAKEKIQAARSLSLGGGGNVCPLLIREVFIQVLIRLEVCFVQSFSEADRDIMTLANHWNCPVLSSDSDFCIFDLRSGFCSLNSFQWRNLNTIKDTQDYYIPARSFSLNAFCHYFNNMNKALLPLFAVLCGNDHVNLPIMDTFISKVRLPLSSKGRRYHRVLGLLNWLSHFDDPTEALDNVLKSLPKKSRENVKELLCCSMEEYQQSPVKLQDFFQYGSYVCTDASDLGLPEWVLGALAKGQLPPFISDALVLRRTFLHTQVENMQRPNAHRISQPIRQIIYGLLLNGPSHAEDIAQNTLPSQLLAFNEVERIDTNIKTSTVYAKQLLKDQCDLSKLAELPLARRQMLLLEALKVKQVVLESIPTFLKLPIAVTCYWLQSTEAKAKLHHLQALLLGMLREPLHAIVNSPGTEDPQRGGAKMLYEELCQVKAPMRPGPRVDLDTAHVFCQWQSCLQMGLYLNQLLSTPLPEPNLTWLYNGSLVHRLCQQLPASSSVESLLSLCPEAKQLYEHLFNATKSYAPAELFLPKTKSKSKKKRQKKKVASLGTTADAKHWYDRSNRFGPLMPESLEEHVENSELE
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: Structure-specific DNA endonuclease that specifically cleaves single-stranded DNA and 3' overhang DNA (By similarity). Contributes to the control of DNA double-strand break repair choice by antagonizing BRCA1-dependent homologous recombination (HR) and promoting non-homologous end-joining (NHEJ) (PubMed:34354233). Recruited to the single-stranded DNA ends by SHLD2 and cleaves the 3' exposed DNA ends, therefore inhibiting DNA end resection (necessary for HR) and promoting DNA end protection (necessary for NHEJ) (By similarity). {ECO:0000250|UniProtKB:Q2TB18, ECO:0000269|PubMed:34354233}.
uniprot
proteins
mass_dalton
76370
uniprot
proteins
protein_family
Asteroid family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
34354233
uniprot
proteins
sequence_length
672
uniprot
proteins