Msl3
entrez
17692
canonical
uniprot
Q9WVG9
canonical
ensembl
ENSMUSG00000031358
resolver
ensp
ENSMUSP00000033725
resolver
ensp
ENSMUSP00000107765
resolver
ensp
ENSMUSP00000222850
resolver
ensp
ENSMUSP00000222851
resolver
ensp
ENSMUSP00000222860
resolver
genesymbol
Msl3
resolver
genesymbol_syn
Msl31
resolver
genesymbol_syn
Msl3l1
resolver
uniprot
B1AUJ7
resolver
uniprot
B1AUJ8
resolver
uniprot_entry
MS3L1_MOUSE
resolver
uniprot_sec
B1AUJ7
resolver
uniprot_sec
B1AUJ8
resolver
amino_acid_sequence
MSASEGMKFQFHSGEKVLCFEPDPTKARVLYDAKIIDVIIGKDEKGRKIPEYLIHFNGWNRSWDRWAAEEHVLHDTDENRRLQRKLAKKAIARLRGTGKKKRRCRLPGVDSVLKSVPVKEKSKNDENSVSSTCHESCGEKNGGIKEHRQRRIKVKAKAKKKVLSLRSRKEMDERTITIDIPDVLKKQLEDDCYYINRRKRLVKLPCQTNIITILESYVKHFAINAAFSANERPRHHHAMMHTHMNVHYVPAEKNVDLCKEMVDGLRITFDYTLPLVLLYPYEQTQYKRVTSSKFFLPIKESTTTTNRSQEELSPSPPLLNPSTPQSTESQPPTGEPATPKRRKAEPEALQSLRRSTRHSTNCDRLSESSSSPQPKRRQQDTSASMPKLFLHLEKKTPVHSRSSSPIPLTPSKDGSAVFAGFEGRRPNEINEVLSWKLVPDNYPPGDQPPPPSYIYGAQHLLRLFVKLPEILGKMSFSEKNLKALLKHFDLFLRFLAEYHDDFFPESAYVAACEAHYSTKNPRAIY
uniprot
proteins
function
FUNCTION: Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:24842875). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (By similarity). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome. X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (PubMed:24842875). Acts as a histone reader that specifically recognizes and binds histone H4 monomethylated at 'Lys-20' (H4K20Me1) in a DNA-dependent manner and is proposed to be involved in chromosomal targeting of the MSL complex. May play a role X inactivation in females (By similarity). {ECO:0000250|UniProtKB:Q8N5Y2, ECO:0000250|UniProtKB:Q9D1P2, ECO:0000269|PubMed:24842875}.
uniprot
proteins
mass_dalton
60292
uniprot
proteins
pubmed
10395802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21217699
uniprot
proteins
pubmed
24842875
uniprot
proteins
pubmed
37847071
uniprot
proteins
sequence_length
525
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8N5Y2}.
uniprot
proteins