Tmem258
entrez
69038
canonical
uniprot
P61166
canonical
ensembl
ENSMUSG00000036372
resolver
ensp
ENSMUSP00000044751
resolver
ensp
ENSMUSP00000128883
resolver
enst
ENSMUST00000040372
resolver
enst
ENSMUST00000166412
resolver
genesymbol
Tmem258
resolver
genesymbol_syn
1810006K21Rik
resolver
uniprot
E9Q853
resolver
uniprot
Q60FD1
resolver
uniprot
Q9D953
resolver
uniprot
Q9Y2Q7
resolver
uniprot_entry
E9Q853_MOUSE
resolver
uniprot_entry
Q60FD1_MOUSE
resolver
uniprot_entry
TM258_MOUSE
resolver
uniprot_sec
Q9D953
resolver
uniprot_sec
Q9Y2Q7
resolver
amino_acid_sequence
MELEAMSRYTSPVNPAVFPHLTVVLLAIGMFFTAWFFVYEVTSTKYTRDIYKELLISLVASLFMGFGVLFLLLWVGIYV
uniprot
proteins
function
FUNCTION: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (By similarity). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Involved in ER homeostasis in the colonic epithelium. {ECO:0000250|UniProtKB:P61165, ECO:0000269|PubMed:27974209}.
uniprot
proteins
mass_dalton
9079
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000250|UniProtKB:P61165}.
uniprot
proteins
protein_family
OST5 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
27974209
uniprot
proteins
sequence_length
79
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:P61165}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P61165}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P61165}. Cytoplasm {ECO:0000250|UniProtKB:P61165}.
uniprot
proteins
transmembrane_region
TRANSMEM 17..37; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 55..75; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins