COPS9
entrez
150678
canonical
uniprot
Q8WXC6
canonical
ensembl
ENSG00000172428
resolver
ensp
ENSP00000304147
resolver
ensp
ENSP00000475979
resolver
genesymbol
COPS9
resolver
genesymbol_syn
MYEOV2
resolver
hgnc
HGNC:21314
resolver
uniprot
Q8N110
resolver
uniprot_entry
CSN9_HUMAN
resolver
uniprot_sec
Q8N110
resolver
amino_acid_sequence
MKPAVDEMFPEGAGPYVDLDEAGGSTGLLMDLAANEKAVHADFFNDFEDLFDDDDIQ
uniprot
proteins
function
FUNCTION: [Isoform 1]: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Plays a role in cell proliferation. {ECO:0000269|PubMed:26456823}.; FUNCTION: [Isoform 2]: Negatively regulates neddylation of proteins, including ribosoaml protein RPL11. {ECO:0000269|PubMed:23776465}.
uniprot
proteins
mass_dalton
6211
uniprot
proteins
mutagenesis
MUTAGEN 44; /note="F->A: Does not abolish interaction with CSN complex. Abolishes interaction with CSN complex; when associated with A-51."; /evidence="ECO:0000269|PubMed:26456823"; MUTAGEN 51; /note="F->A: Decreases interaction with CSN complex. Abolishes interaction with CSN complex; when associated with A-44."; /evidence="ECO:0000269|PubMed:26456823
uniprot
proteins
protein_family
CSN9 family
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
23776465
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26456823
uniprot
proteins
sequence_length
57
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000269|PubMed:26456823}. Cytoplasm {ECO:0000269|PubMed:26456823}. Nucleus, nucleoplasm {ECO:0000269|PubMed:26456823}. Note=Excluded from the nucleolus. Recruited to the nucleoplasm and chromatin following DNA damage induction. {ECO:0000269|PubMed:26456823}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus, nucleoplasm {ECO:0000269|PubMed:23776465}. Note=Excluded from the nucleolus. {ECO:0000269|PubMed:23776465}.
uniprot
proteins