Ecrg4
entrez
363225
canonical
uniprot
D4A540
canonical
ensembl
ENSRNOG00000023576
resolver
ensp
ENSRNOP00000030526
resolver
enst
ENSRNOT00000036990
resolver
genesymbol
Ecrg4
resolver
uniprot_entry
AUGN_RAT
resolver
amino_acid_sequence
MGTSSARPAVLALAGLALLLLLCLGPGDVSGNKLKKMLQKREGPVPSKTNVAVSEHTAKEFLGGLKRAKRQLWDRTRPEVQQWYQQFLYMGFDEAKFEDDVNYWLNRNQNGHDYYGDYYQRHYDEDAAIGPRSREGFRHGASVNYDDY
uniprot
proteins
function
FUNCTION: Probable hormone that may attenuate cell proliferation and induce senescence of oligodendrocyte and neural precursor cells in the central nervous system (PubMed:20404145, PubMed:21349154). ECRG4-induced senescence is characterized by G1 arrest, RB1 dephosphorylation and accelerated CCND1 and CCND3 proteasomal degradation (PubMed:20404145). {ECO:0000269|PubMed:20404145, ECO:0000269|PubMed:21349154}.
uniprot
proteins
mass_dalton
16949
uniprot
proteins
protein_family
Augurin family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
20404145
uniprot
proteins
pubmed
21349154
uniprot
proteins
pubmed
26479776
uniprot
proteins
sequence_length
148
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9H1Z8}. Cytoplasm {ECO:0000269|PubMed:21349154}. Apical cell membrane {ECO:0000250|UniProtKB:Q9H1Z8}.
uniprot
proteins