SORBS2
entrez
8470
canonical
uniprot
O94875
canonical
ensembl
ENSG00000154556
resolver
ensp
ENSP00000284776
resolver
ensp
ENSP00000322182
resolver
ensp
ENSP00000347852
resolver
ensp
ENSP00000377162
resolver
ensp
ENSP00000396008
resolver
ensp
ENSP00000397262
resolver
ensp
ENSP00000401818
resolver
ensp
ENSP00000511887
resolver
ensp
ENSP00000511888
resolver
ensp
ENSP00000511889
resolver
ensp
ENSP00000511891
resolver
ensp
ENSP00000535753
resolver
enst
ENST00000490562
resolver
enst
ENST00000695409
resolver
enst
ENST00000695410
resolver
genesymbol
SORBS2
resolver
genesymbol_syn
ARGBP2
resolver
genesymbol_syn
KIAA0777
resolver
hgnc
HGNC:24098
resolver
uniprot
A0A8Q3WKF2
resolver
uniprot
A0A8Q3WKH1
resolver
uniprot
A0A8Q3WKK4
resolver
uniprot
A6NEK9
resolver
uniprot
B3KPQ7
resolver
uniprot
B7Z1G5
resolver
uniprot
B7Z3D7
resolver
uniprot
B7Z3X6
resolver
uniprot
B7Z997
resolver
uniprot
C9JKV9
resolver
uniprot
D3DP62
resolver
uniprot
D3DP63
resolver
uniprot
E9PAS5
resolver
uniprot
E9PAW4
resolver
uniprot
G3XAI0
resolver
uniprot
H7BXR4
resolver
uniprot
J3KNZ5
resolver
uniprot
O60592
resolver
uniprot
O60593
resolver
uniprot
Q96EX0
resolver
uniprot_entry
A0A8Q3WKF2_HUMAN
resolver
uniprot_entry
A0A8Q3WKH1_HUMAN
resolver
uniprot_entry
A0A8Q3WKK4_HUMAN
resolver
uniprot_entry
B7Z3D7_HUMAN
resolver
uniprot_entry
B7Z997_HUMAN
resolver
uniprot_entry
SRBS2_HUMAN
resolver
uniprot_sec
A6NEK9
resolver
uniprot_sec
B3KPQ7
resolver
uniprot_sec
B7Z1G5
resolver
uniprot_sec
B7Z3X6
resolver
uniprot_sec
C9JKV9
resolver
uniprot_sec
D3DP62
resolver
uniprot_sec
D3DP63
resolver
uniprot_sec
E9PAS5
resolver
uniprot_sec
E9PAW4
resolver
uniprot_sec
G3XAI0
resolver
uniprot_sec
H7BXR4
resolver
uniprot_sec
J3KNZ5
resolver
uniprot_sec
O60592
resolver
uniprot_sec
O60593
resolver
uniprot_sec
Q96EX0
resolver
amino_acid_sequence
MSYYQRPFSPSAYSLPASLNSSIVMQHGTSLDSTDTYPQHAQSLDGTTSSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPDDDTDMYNTPYTYNAGLYNPPYSAQSHPAAKTQTYRPLSKSHSDNSPNAFKDASSPVPPPHVPPPVPPLRPRDRSSTEKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPASLYQSSIDRSLERPMSSASMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAKGGDDSKICPSLCSYSGLNGNPSSELDYCSTYRQHLDVPRDSPRAISFKNGWQMARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKVKSESMGSLLCEEDSKESCPMAWGSPYVPEVRSNGRSRIRHRSARNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRILQYESEQQHKDLLRAWSQCSTEEVPRDMVPTRISEFEKLIQKSKSMPNLGDDMLSPVTLEPPQNGLCPKRRFSIEYLLEEENQSGPPARGRRGCQSNALVPIHIEVTSDEQPRAHVEFSDSDQDGVVSDHSDYIHLEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHHRHLISSCKGRCPASYTRFTTMLKHERARHENTEEPRRQEMDPGLSKLAFLVSPVPFRRKKNSAPKKQTEKAKCKASVFEALDSALKDICDQIKAEKKRGSLPDNSILHRLISELLPDVPERNSSLRALRRSPLHQPLHPLPPDGAIHCPPYQNDCGRMPRSASFQDVDTANSSCHHQDRGGALQDRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPAQPGEIGEAIAKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKKNTKGAEDYPDPPIPHSYSSDRIHSLSSNKPQRPVFTHENIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYVKRL
uniprot
proteins
function
FUNCTION: Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (PubMed:18559503). Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. {ECO:0000269|PubMed:12475393, ECO:0000269|PubMed:18559503, ECO:0000269|PubMed:9211900}.
uniprot
proteins
mass_dalton
124108
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by CBL. {ECO:0000269|PubMed:12475393}.; PTM: Dephosphorylated by PTPN12. {ECO:0000269|PubMed:18559503}.
uniprot
proteins
pubmed
11786189
uniprot
proteins
pubmed
12475393
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15784622
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16125169
uniprot
proteins
pubmed
18559503
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
27825083
uniprot
proteins
pubmed
9211900
uniprot
proteins
pubmed
9872452
uniprot
proteins
sequence_length
1100
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region {ECO:0000269|PubMed:16125169, ECO:0000269|PubMed:9211900}. Apical cell membrane {ECO:0000269|PubMed:18559503}. Cell junction, focal adhesion {ECO:0000269|PubMed:18559503}. Cell projection, lamellipodium {ECO:0000269|PubMed:18559503}. Note=Found at the Z-disk sarcomeres, stress fibers, dense bodies and focal adhesion. In pancreatic acinar cells, localized preferentially to the apical membrane. Colocalized with vinculin and filamentous actin at focal adhesions and lamellipodia of pancreatic cells. {ECO:0000269|PubMed:18559503}.
uniprot
proteins