A4galt
entrez
63888
canonical
uniprot
Q9JI93
canonical
ensembl
ENSRNOG00000009736
resolver
ensembl
ENSRNOG00055031189
resolver
ensembl
ENSRNOG00060030725
resolver
ensembl
ENSRNOG00065033099
resolver
ensp
ENSRNOP00000064362
resolver
ensp
ENSRNOP00000081935
resolver
ensp
ENSRNOP00000084868
resolver
ensp
ENSRNOP00000095592
resolver
ensp
ENSRNOP00000098821
resolver
ensp
ENSRNOP00000112147
resolver
ensp
ENSRNOP00055044706
resolver
ensp
ENSRNOP00055044712
resolver
ensp
ENSRNOP00055044713
resolver
ensp
ENSRNOP00055044714
resolver
ensp
ENSRNOP00060044364
resolver
ensp
ENSRNOP00060044373
resolver
ensp
ENSRNOP00060044377
resolver
ensp
ENSRNOP00060044378
resolver
ensp
ENSRNOP00065046880
resolver
ensp
ENSRNOP00065046885
resolver
ensp
ENSRNOP00065046889
resolver
ensp
ENSRNOP00065046892
resolver
enst
ENSRNOT00000012914
resolver
enst
ENSRNOT00000096640
resolver
enst
ENSRNOT00000104849
resolver
enst
ENSRNOT00000108253
resolver
enst
ENSRNOT00000122895
resolver
enst
ENSRNOT00000151164
resolver
enst
ENSRNOT00055054040
resolver
enst
ENSRNOT00055054051
resolver
enst
ENSRNOT00055054056
resolver
enst
ENSRNOT00055054060
resolver
enst
ENSRNOT00060053385
resolver
enst
ENSRNOT00060053401
resolver
enst
ENSRNOT00060053407
resolver
enst
ENSRNOT00060053410
resolver
enst
ENSRNOT00065056939
resolver
enst
ENSRNOT00065056944
resolver
enst
ENSRNOT00065056948
resolver
enst
ENSRNOT00065056951
resolver
genesymbol
A4galt
resolver
uniprot
Q4QR98
resolver
uniprot_entry
A4GAT_RAT
resolver
uniprot_sec
Q4QR98
resolver
amino_acid_sequence
MGISRSDLEETMSKPPDCLPRMLRGTPRQRVFTLFIISFKFTFLVSILIYWHTVGAPKDQRRQYSLPVDFPCPQLAFPRVSAPGNIFFLETSDRTNPSFLFMCSVESAARAHPESQVVVLMKGLPRDTTAWPRNLGISLLSCFPNVQIRPLDLQELFEDTPLAAWYLEAQHRWEPYLLPVLSDASRIALLWKFGGIYLDTDFIVLKNLRNLTNMLGIQSRYVLNGAFLAFERKHEFLALCIRDFVAHYNGWIWGHQGPQLLTRVFKKWCSIHSLKESRACRGVTALPPEAFYPIPWQNWKKYFEDVSPEELAQLLNATYAVHVWNKKSQGTHLEATSRALLAQLHARYCPTTHRAMTMYL
uniprot
proteins
ec_number
2.4.1.228
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of galactose from UDP-alpha-D-galactose in an alpha1,4 linkage to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide(d18:1(4E)) to produce globotriaosylceramide/globoside Gb3Cer (d18:1(4E)), also known as CD77 (PubMed:10854428). Globoside Gb3Cer/CD77 is a root structure in biosynthesis pathway of neutral glycosphingolipids of the globo-series. Broadly expressed in cell membranes of immune cells and other tissues, Gb3Cer/CD77 antigen may participate in mechanisms that regulate cell-cell interactions and cell differentiation. In germinal center B cells, Gb3Cer/CD77 interacts with CD19 to drive centroblast-to-centrocyte transition, B cell receptor complex assembly and T follicular helper cell differentiation. In epithelium, Gb3Cer/CD77 regulates CDH1/E-cadherin-dependent cell-cell adhesion counteracting epithelial-to-mesenchymal transition (By similarity). Also able to transfer galactose to galactosylceramide/beta-D-Gal-(1<->1')-Cer (By similarity). {ECO:0000250|UniProtKB:Q67BJ4, ECO:0000250|UniProtKB:Q9NPC4, ECO:0000269|PubMed:10854428}.
uniprot
proteins
mass_dalton
41551
uniprot
proteins
mutagenesis
MUTAGEN 199..201; /note="DTD->ATA: Loss of activity."; /evidence="ECO:0000269|PubMed:10854428
uniprot
proteins
pathway_participation
PATHWAY: Glycolipid biosynthesis. {ECO:0000305|PubMed:10854428}.
uniprot
proteins
protein_family
Glycosyltransferase 32 family
uniprot
proteins
pubmed
10854428
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
360
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 31..51; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins