ENC1
entrez
8507
canonical
uniprot
O14682
canonical
ensembl
ENSG00000171617
resolver
ensp
ENSP00000306356
resolver
ensp
ENSP00000423804
resolver
ensp
ENSP00000479101
resolver
ensp
ENSP00000545752
resolver
ensp
ENSP00000545754
resolver
genesymbol
ENC1
resolver
genesymbol_syn
KLHL37
resolver
genesymbol_syn
NRPB
resolver
genesymbol_syn
PIG10
resolver
hgnc
HGNC:3345
resolver
uniprot
B4DHJ1
resolver
uniprot
E9PFU0
resolver
uniprot
O75464
resolver
uniprot
Q53XS2
resolver
uniprot
Q9UPG9
resolver
uniprot_entry
ENC1_HUMAN
resolver
uniprot_entry
Q53XS2_HUMAN
resolver
uniprot_sec
B4DHJ1
resolver
uniprot_sec
E9PFU0
resolver
uniprot_sec
O75464
resolver
uniprot_sec
Q9UPG9
resolver
amino_acid_sequence
MSVSVHENRKSRASSGSINIYLFHKSSYADSVLTHLNLLRQQRLFTDVLLHAGNRTFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFDNSIHPEVLELLLDYAYSSRVIINEENAESLLEAGDMLEFQDIRDACAEFLEKNLHPTNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTIRKNEDFLQLPQDMVVQLLSSEELETEDERLVYESAINWISYDLKKRYCYLPELLQTVRLALLPAIYLMENVAMEELITKQRKSKEIVEEAIRCKLKILQNDGVVTSLCARPRKTGHALFLLGGQTFMCDKLYLVDQKAKEIIPKADIPSPRKEFSACAIGCKVYITGGRGSENGVSKDVWVYDTLHEEWSKAAPMLVARFGHGSAELKHCLYVVGGHTAATGCLPASPSVSLKQVEHYDPTINKWTMVAPLREGVSNAAVVSAKLKLFAFGGTSVSHDKLPKVQCYDQCENRWTVPATCPQPWRYTAAAVLGNQIFIMGGDTEFSACSAYKFNSETYQWTKVGDVTAKRMSCHAVASGNKLYVVGGYFGIQRCKTLDCYDPTLDVWNSITTVPYSLIPTAFVSTWKHLPS
uniprot
proteins
function
FUNCTION: Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism. {ECO:0000269|PubMed:19424503}.
uniprot
proteins
mass_dalton
66130
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by E3 ubiquitin ligase complex formed by CUL3 and RBX1 and probably targeted for proteasome-independent degradation. Quinone-induced oxidative stress increases its ubiquitination. {ECO:0000269|PubMed:15983046}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15983046
uniprot
proteins
pubmed
19424503
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
9305847
uniprot
proteins
pubmed
9566959
uniprot
proteins
pubmed
9683534
uniprot
proteins
sequence_length
589
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus matrix {ECO:0000269|PubMed:19424503}. Cytoplasm {ECO:0000269|PubMed:19424503}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19424503}.
uniprot
proteins