Tle5
entrez
14797
canonical
uniprot
P63002
canonical
ensembl
ENSMUSG00000054452
resolver
ensp
ENSMUSP00000002518
resolver
ensp
ENSMUSP00000209340
resolver
genesymbol
Tle5
resolver
genesymbol_syn
Aes
resolver
genesymbol_syn
Esp1
resolver
genesymbol_syn
Grg
resolver
genesymbol_syn
Grg5
resolver
uniprot
B7ZNK7
resolver
uniprot
Q06195
resolver
uniprot
Q3TYD9
resolver
uniprot_entry
B7ZNK7_MOUSE
resolver
uniprot_entry
Q3TYD9_MOUSE
resolver
uniprot_entry
TLE5_MOUSE
resolver
uniprot_sec
Q06195
resolver
amino_acid_sequence
MMFPQSRHSGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLKLECDKLASEKSEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQQVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALALPLTPLPVGLQPPSLPAVSAGTGLLSLSALGSQTHLSKEDKNGHDGDTHQEDDGEKSD
uniprot
proteins
function
FUNCTION: Transcriptional corepressor. Acts as a dominant repressor towards other family members. Inhibits NF-kappa-B-regulated gene expression. May be required for the initiation and maintenance of the differentiated state. Essential for the transcriptional repressor activity of SIX3 during retina and lens development. {ECO:0000269|PubMed:12050133}.
uniprot
proteins
mass_dalton
22000
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by XIAP/BIRC4. {ECO:0000250}.
uniprot
proteins
protein_family
WD repeat Groucho/TLE family
uniprot
proteins
pubmed
11266540
uniprot
proteins
pubmed
12050133
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8365415
uniprot
proteins
pubmed
8369224
uniprot
proteins
pubmed
9783587
uniprot
proteins
sequence_length
197
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12050133}.
uniprot
proteins