Stxbp1
entrez
20910
canonical
uniprot
O08599
canonical
ensembl
ENSMUSG00000026797
resolver
ensp
ENSMUSP00000052440
resolver
ensp
ENSMUSP00000089051
resolver
genesymbol
Stxbp1
resolver
uniprot
A2ARS2
resolver
uniprot
A2ARS3
resolver
uniprot
A2ARS4
resolver
uniprot
Q5WAC6
resolver
uniprot
Q8VD51
resolver
uniprot_entry
STXB1_MOUSE
resolver
uniprot_sec
A2ARS2
resolver
uniprot_sec
A2ARS3
resolver
uniprot_sec
A2ARS4
resolver
uniprot_sec
Q5WAC6
resolver
uniprot_sec
Q8VD51
resolver
amino_acid_sequence
MAPIGLKAVVGEKIMHDVIKKVKKKGEWKVLVVDQLSMRMLSSCCKMTDIMTEGITIVEDINKRREPLPSLEAVYLITPSEKSVHSLISDFKDPPTAKYRAAHVFFTDSCPDALFNELVKSRAAKVIKTLTEINIAFLPYESQVYSLDSADSFQSFYSPHKAQMKNPILERLAEQIATLCATLKEYPAVRYRGEYKDNALLAQLIQDKLDAYKADDPTMGEGPDKARSQLLILDRGFDPSSPVLHELTFQAMSYDLLPIENDVYKYETSGIGEARVKEVLLDEDDDLWIALRHKHIAEVSQEVTRSLKDFSSSKRMNTGEKTTMRDLSQMLKKMPQYQKELSKYSTHLHLAEDCMKHYQGTVDKLCRVEQDLAMGTDAEGEKIKDPMRAIVPILLDANVSTYDKIRIILLYIFLKNGITEENLNKLIQHAQIPPEDSEIITNMAHLGVPIVTDSTLRRRSKPERKERISEQTYQLSRWTPIIKDIMEDTIEDKLDTKHYPYISTRSSASFSTTAVSARYGHWHKNKAPGEYRSGPRLIIFILGGVSLNEMRCAYEVTQANGKWEVLIGSTHILTPQKLLDTLKKLNKTDEEISS
uniprot
proteins
function
FUNCTION: Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins (By similarity). Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. Involved in the release of neurotransmitters from neurons through interacting with SNARE complex component STX1A and mediating the assembly of the SNARE complex at synaptic membranes (PubMed:21445306, PubMed:28821673). May play a role in determining the specificity of intracellular fusion reactions (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P61765, ECO:0000269|PubMed:21445306, ECO:0000269|PubMed:28821673}.
uniprot
proteins
mass_dalton
67569
uniprot
proteins
mutagenesis
MUTAGEN 335; /note="P->A: Enhances binding to SNARE complex component STX1A promoting formation of the SNARE complex and thereby increasing release of neurotransmitters from neurons and thus synaptic transmission."; /evidence="ECO:0000269|PubMed:28821673
uniprot
proteins
protein_family
STXBP/unc-18/SEC1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21445306
uniprot
proteins
pubmed
22039235
uniprot
proteins
pubmed
28821673
uniprot
proteins
pubmed
8824310
uniprot
proteins
pubmed
9705297
uniprot
proteins
sequence_length
594
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P61764}. Membrane; Peripheral membrane protein.
uniprot
proteins