Arg1
entrez
11846
canonical
uniprot
Q61176
canonical
ensembl
ENSMUSG00000019987
resolver
ensp
ENSMUSP00000020161
resolver
enst
ENSMUST00000020161
resolver
genesymbol
Arg1
resolver
uniprot
Q3TB74
resolver
uniprot
Q3UEL0
resolver
uniprot
Q4FK78
resolver
uniprot
Q80VI4
resolver
uniprot_entry
ARGI1_MOUSE
resolver
uniprot_sec
Q3TB74
resolver
uniprot_sec
Q3UEL0
resolver
uniprot_sec
Q4FK78
resolver
uniprot_sec
Q80VI4
resolver
amino_acid_sequence
MSSKPKSLEIIGAPFSKGQPRGGVEKGPAALRKAGLLEKLKETEYDVRDHGDLAFVDVPNDSSFQIVKNPRSVGKANEELAGVVAEVQKNGRVSVVLGGDHSLAVGSISGHARVHPDLCVIWVDAHTDINTPLTTSSGNLHGQPVSFLLKELKGKFPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYIIKTLGIKYFSMTEVDKLGIGKVMEETFSYLLGRKKRPIHLSFDVDGLDPAFTPATGTPVLGGLSYREGLYITEEIYKTGLLSGLDIMEVNPTLGKTAEEVKSTVNTAVALTLACFGTQREGNHKPGTDYLKPPK
uniprot
proteins
ec_number
3.5.3.1
uniprot
proteins
function
FUNCTION: Catalyzes the final step of the urea cycle by hydrolyzing L-arginine into urea, a nitrogenous waste product, and L-ornithine, a precursor to proline and polyamines; the urea cycle occurs primarily in the liver and, to a lesser extent, in the kidneys. {ECO:0000305}.; FUNCTION: Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death, is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion (By similarity). In group 2 innate lymphoid cells (ILC2s) promotes acute type 2 inflammation in the lung and is involved in optimal ILC2 proliferation but not survival (PubMed:27043409). Plays a role in the immune response of alternatively activated or M2 macrophages in processes such as wound healing and tissue regeneration, immune defense against multicellular pathogens and parasites, and immune suppression and allergic inflammation; the regulatory outcome seems to be organ specific (PubMed:19360123, PubMed:20483789, PubMed:23552798, PubMed:23637937, PubMed:7537672). In tumor-infiltrating dendritic cells (DCs) and myeloid-derived suppressor cells (MDSCs) plays a role in suppression of T cell-mediated antitumor immunity (PubMed:19414774, PubMed:23248265). {ECO:0000250|UniProtKB:P05089, ECO:0000269|PubMed:15313928, ECO:0000269|PubMed:19360123, ECO:0000269|PubMed:19414774, ECO:0000269|PubMed:20483789, ECO:0000269|PubMed:23248265, ECO:0000269|PubMed:23552798, ECO:0000269|PubMed:23637937, ECO:0000269|PubMed:27043409, ECO:0000269|PubMed:7537672}.
uniprot
proteins
mass_dalton
34808
uniprot
proteins
pathway_participation
PATHWAY: Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1. {ECO:0000250|UniProtKB:P05089}.
uniprot
proteins
protein_family
Arginase family
uniprot
proteins
pubmed
12193690
uniprot
proteins
pubmed
15313928
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19360123
uniprot
proteins
pubmed
19414774
uniprot
proteins
pubmed
20483789
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23248265
uniprot
proteins
pubmed
23552798
uniprot
proteins
pubmed
23637937
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
27043409
uniprot
proteins
pubmed
7537672
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P05089}. Cytoplasmic granule {ECO:0000250|UniProtKB:P05089}. Note=Localized in azurophil granules of neutrophils. {ECO:0000250|UniProtKB:P05089}.
uniprot
proteins