Abi1
entrez
79249
canonical
uniprot
Q9QZM5
canonical
ensembl
ENSRNOG00000031325
resolver
ensp
ENSRNOP00000054381
resolver
ensp
ENSRNOP00000071079
resolver
ensp
ENSRNOP00000081022
resolver
ensp
ENSRNOP00000093871
resolver
enst
ENSRNOT00000057572
resolver
enst
ENSRNOT00000091023
resolver
enst
ENSRNOT00000093928
resolver
enst
ENSRNOT00000108948
resolver
genesymbol
Abi1
resolver
uniprot
A0A140TAH6
resolver
uniprot
A0A8I5ZQS1
resolver
uniprot
A0A8I6AGM2
resolver
uniprot
A0A8L2UQ93
resolver
uniprot
A2VD09
resolver
uniprot_entry
A0A140TAH6_RAT
resolver
uniprot_entry
A0A8I5ZQS1_RAT
resolver
uniprot_entry
A0A8I6AGM2_RAT
resolver
uniprot_entry
A0A8L2UQ93_RAT
resolver
uniprot_entry
A2VD09_RAT
resolver
uniprot_entry
ABI1_RAT
resolver
amino_acid_sequence
MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLASVAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSRTHKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKHGNNQPARTGTLSRTNPPTQKPPSPPVSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHSGSSGGSGSRENSGSSSIGIPIAVPTPSPPTAGPAAPGAAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSISIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYSDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFKEGAIIYVIKKNDDGWFEGVCNRVTGLFPGNYVESIMHYTD
uniprot
proteins
function
FUNCTION: May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 participates in transduction of signals from Ras to Rac. In vitro, a trimeric complex of ABI1, EPS8 and SOS1 exhibits Rac specific guanine nucleotide exchange factor (GEF) activity and ABI1 seems to act as an adapter in the complex. Regulates ABL1/c-Abl-mediated phosphorylation of ENAH. Recruits WASF1 to lamellipodia and there seems to regulate WASF1 protein level. In brain, seems to regulate the dendritic outgrowth and branching as well as to determine the shape and number of synaptic contacts of developing neurons. {ECO:0000269|PubMed:17304222}.
uniprot
proteins
mass_dalton
51705
uniprot
proteins
mutagenesis
MUTAGEN 53; /note="Y->A: Not phosphorylated and perinuclear upon NMDA treatment."; /evidence="ECO:0000269|PubMed:17304222
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on tyrosine residues after serum stimulation or induction by v-Abl. Seems to be phosphorylated at Tyr-53 by ABL1, required for nuclear but not for synaptic localization. {ECO:0000269|PubMed:17304222}.
uniprot
proteins
protein_family
ABI family
uniprot
proteins
pubmed
10995551
uniprot
proteins
pubmed
17304222
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
476
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:17304222}. Cell projection, lamellipodium {ECO:0000269|PubMed:17304222}. Cell projection, filopodium {ECO:0000269|PubMed:17304222}. Cell projection, growth cone {ECO:0000269|PubMed:10995551}. Postsynaptic density {ECO:0000269|PubMed:10995551, ECO:0000269|PubMed:17304222}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17304222}. Note=Localized to protruding lamellipodia and filopodia tips. May shuttle from the postsynaptic densities to the nucleus. {ECO:0000269|PubMed:10995551, ECO:0000269|PubMed:17304222}.
uniprot
proteins