Ly6e
entrez
17069
canonical
uniprot
Q64253
canonical
ensembl
ENSMUSG00000022587
resolver
ensp
ENSMUSP00000139471
resolver
ensp
ENSMUSP00000139482
resolver
ensp
ENSMUSP00000139549
resolver
ensp
ENSMUSP00000139966
resolver
ensp
ENSMUSP00000140145
resolver
ensp
ENSMUSP00000140553
resolver
ensp
ENSMUSP00000141059
resolver
ensp
ENSMUSP00000141145
resolver
enst
ENSMUST00000185861
resolver
enst
ENSMUST00000187284
resolver
enst
ENSMUST00000187606
resolver
enst
ENSMUST00000188042
resolver
enst
ENSMUST00000188866
resolver
enst
ENSMUST00000190810
resolver
enst
ENSMUST00000191127
resolver
enst
ENSMUST00000191436
resolver
genesymbol
Ly6e
resolver
genesymbol_syn
Ly67
resolver
genesymbol_syn
Sca-2
resolver
genesymbol_syn
Tsa-1
resolver
uniprot
A0A087WNT2
resolver
uniprot
A0A087WPY4
resolver
uniprot
Q61128
resolver
uniprot
Q99JA5
resolver
uniprot_entry
A0A087WPY4_MOUSE
resolver
uniprot_entry
LY6E_MOUSE
resolver
uniprot_sec
A0A087WNT2
resolver
uniprot_sec
Q61128
resolver
uniprot_sec
Q99JA5
resolver
amino_acid_sequence
MSATSNMRVFLPVLLAALLGMEQVHSLMCFSCTDQKNNINCLWPVSCQEKDHYCITLSAAAGFGNVNLGYTLNKGCSPICPSENVNLNLGVASVNSYCCQSSFCNFSAAGLGLRASIPLLGLGLLLSLLALLQLSP
uniprot
proteins
function
FUNCTION: GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation (PubMed:8642345, PubMed:9575182). Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation (PubMed:9575182). Restricts the entry of murine coronavirus, mouse hepatitis virus, by interfering with spike protein-mediated membrane fusion (PubMed:32704094). Also plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA) (PubMed:28679758). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta (PubMed:29500366). May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response (PubMed:26276394). {ECO:0000269|PubMed:26276394, ECO:0000269|PubMed:28679758, ECO:0000269|PubMed:29500366, ECO:0000269|PubMed:32704094, ECO:0000269|PubMed:8642345, ECO:0000269|PubMed:9575182}.
uniprot
proteins
mass_dalton
14392
uniprot
proteins
pubmed
11784869
uniprot
proteins
pubmed
1531995
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26276394
uniprot
proteins
pubmed
28679758
uniprot
proteins
pubmed
29500366
uniprot
proteins
pubmed
2987354
uniprot
proteins
pubmed
3040423
uniprot
proteins
pubmed
32704094
uniprot
proteins
pubmed
7499840
uniprot
proteins
pubmed
8202484
uniprot
proteins
pubmed
8258699
uniprot
proteins
pubmed
8642345
uniprot
proteins
pubmed
8662090
uniprot
proteins
pubmed
9575182
uniprot
proteins
sequence_length
136
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9575182}; Lipid-anchor, GPI-anchor {ECO:0000305}.
uniprot
proteins