Nectin2
entrez
19294
canonical
uniprot
P32507
canonical
ensembl
ENSMUSG00000062300
resolver
ensp
ENSMUSP00000074898
resolver
ensp
ENSMUSP00000104089
resolver
genesymbol
Nectin2
resolver
genesymbol_syn
Mph
resolver
genesymbol_syn
Pvr
resolver
genesymbol_syn
Pvrl2
resolver
genesymbol_syn
Pvs
resolver
uniprot
Q62096
resolver
uniprot
Q80XJ5
resolver
uniprot
Q8C6F2
resolver
uniprot_entry
NECT2_MOUSE
resolver
uniprot_entry
Q80XJ5_MOUSE
resolver
uniprot_entry
Q8C6F2_MOUSE
resolver
uniprot_sec
Q62096
resolver
amino_acid_sequence
MARAAVLPPSRLSPTLPLLPLLLLLLQETGAQDVRVRVLPEVRGRLGGTVELPCHLLPPTTERVSQVTWQRLDGTVVAAFHPSFGVDFPNSQFSKDRLSFVRARPETNADLRDATLAFRGLRVEDEGNYTCEFATFPNGTRRGVTWLRVIAQPENHAEAQEVTIGPQSVAVARCVSTGGRPPARITWISSLGGEAKDTQEPGIQAGTVTIISRYSLVPVGRADGVKVTCRVEHESFEEPILLPVTLSVRYPPEVSISGYDDNWYLGRSEAILTCDVRSNPEPTDYDWSTTSGVFPASAVAQGSQLLVHSVDRMVNTTFICTATNAVGTGRAEQVILVRESPSTAGAGATGGIIGGIIAAIIATAVAGTGILICRQQRKEQRLQAADEEEELEGPPSYKPPTPKAKLEEPEMPSQLFTLGASEHSPVKTPYFDAGVSCADQEMPRYHELPTLEERSGPLLLGATGLGPSLLVPPGPNVVEGVSLSLEDEEEDDEEEDFLDKINPIYDALSYPSPSDSYQSKDFFVSRAMYV
uniprot
proteins
function
FUNCTION: Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein. {ECO:0000250|UniProtKB:Q92692}.
uniprot
proteins
mass_dalton
57318
uniprot
proteins
protein_family
Nectin family
uniprot
proteins
pubmed
10196354
uniprot
proteins
pubmed
10744716
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1560525
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22902367
uniprot
proteins
pubmed
8132569
uniprot
proteins
sequence_length
530
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q92692}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 352..372; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins