Prkcz
entrez
25522
canonical
uniprot
P09217
canonical
ensembl
ENSRNOG00000015480
resolver
ensp
ENSRNOP00000021285
resolver
ensp
ENSRNOP00000108141
resolver
enst
ENSRNOT00000132708
resolver
genesymbol
Prkcz
resolver
genesymbol_syn
Pkcz
resolver
uniprot
A0ABK0LBS7
resolver
uniprot_entry
A0ABK0LBS7_RAT
resolver
uniprot_entry
KPCZ_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Atypical PKCs (PRKCI and PRKCZ) exhibit an elevated basal enzymatic activity (that may be due to the interaction with SMG1 or SQSTM1) and are not regulated by diacylglycerol, phosphatidylserine, phorbol esters or calcium ions. Two specific sites, Thr-410 (activation loop of the kinase domain) and Thr-560 (turn motif), need to be phosphorylated for its full activation. Phosphatidylinositol 3,4,5-trisphosphate might be a physiological activator (Probable). Isoform 2: Constitutively active (PubMed:8378304). {ECO:0000269|PubMed:8378304, ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MPSRTDPKMDRSGGRVRLKAHYGGDILITSVDPTTTFQDLCEEVRDMCGLHQQHPLTLKWVDSEGDPCTVSSQMELEEAFRLACQGRDEVLIIHVFPSIPEQPGMPCPGEDKSIYRRGARRWRKLYRANGHLFQAKRFNRRAYCGQCSERIWGLARQGYRCINCKLLVHKRCHVLVPLTCRRHMDSVMPSQEPPVDDKNDGVDLPSEETDGIAYISSSRKHDNIKDDSEDLKPVIDGVDGIKISQGLGLQDFDLIRVIGRGSYAKVLLVRLKKNDQIYAMKVVKKELVHDDEDIDWVQTEKHVFEQASSNPFLVGLHSCFQTTSRLFLVIEYVNGGDLMFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTTSTFCGTPNYIAPEILRGEEYGFSVDWWALGVLMFEMMAGRSPFDIITDNPDMNTEDYLFQVILEKPIRIPRFLSVKASHVLKGFLNKDPKERLGCRPQTGFSDIKSHAFFRSIDWDLLEKKQTLPPFQPQITDDYGLDNFDTQFTSEPVQLTPDDEDVIKRIDQSEFEGFEYINPLLLSAEESV
uniprot
proteins
ec_number
2.7.11.13
uniprot
proteins
function
FUNCTION: Calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP). Upon lipopolysaccharide (LPS) treatment in macrophages, or following mitogenic stimuli, functions downstream of PI3K to activate MAP2K1/MEK1-MAPK1/ERK2 signaling cascade independently of RAF1 activation. Required for insulin-dependent activation of AKT3, but may function as an adapter rather than a direct activator. Upon insulin treatment may act as a downstream effector of PI3K and contribute to the activation of translocation of the glucose transporter SLC2A4/GLUT4 and subsequent glucose transport in adipocytes. In EGF-induced cells, binds and activates MAP2K5/MEK5-MAPK7/ERK5 independently of its kinase activity and can activate JUN promoter through MEF2C. Through binding with SQSTM1/p62, functions in interleukin-1 signaling and activation of NF-kappa-B with the specific adapters RIPK1 and TRAF6. Participates in TNF-dependent transactivation of NF-kappa-B by phosphorylating and activating IKBKB kinase, which in turn leads to the degradation of NF-kappa-B inhibitors. In migrating astrocytes, forms a cytoplasmic complex with PARD6A and is recruited by CDC42 to function in the establishment of cell polarity along with the microtubule motor and dynein. In association with FEZ1, stimulates neuronal differentiation in PC12 cells. In the inflammatory response, is required for the T-helper 2 (Th2) differentiation process, including interleukin production, efficient activation of JAK1 and the subsequent phosphorylation and nuclear translocation of STAT6. May be involved in development of allergic airway inflammation (asthma), a process dependent on Th2 immune response. In the NF-kappa-B-mediated inflammatory response, can relieve SETD6-dependent repression of NF-kappa-B target genes by phosphorylating the RELA subunit at 'Ser-311'. Phosphorylates VAMP2 in vitro (By similarity). Phosphorylates and activates LRRK1, which phosphorylates RAB proteins involved in intracellular trafficking (By similarity). {ECO:0000250|UniProtKB:Q05513, ECO:0000269|PubMed:10022904, ECO:0000269|PubMed:10747026, ECO:0000269|PubMed:11158308, ECO:0000269|PubMed:11525734, ECO:0000269|PubMed:8557035, ECO:0000269|PubMed:9177193, ECO:0000269|PubMed:9374484}.; FUNCTION: [Isoform 2]: Involved in late synaptic long term potentiation phase in CA1 hippocampal cells and long term memory maintenance. {ECO:0000269|PubMed:11914719, ECO:0000269|PubMed:27498875}.
uniprot
proteins
mass_dalton
67733
uniprot
proteins
mutagenesis
MUTAGEN 62; /note="D->A: Loss of interaction with SQSTM1."; /evidence="ECO:0000269|PubMed:12813044
uniprot
proteins
post_translational_modification
PTM: CDH5 is required for its phosphorylation at Thr-410. Phosphorylated by protein kinase PDPK1; phosphorylation is inhibited by the apoptotic C-terminal cleavage product of PKN2. Phosphorylation at Thr-410 by PI3K activates the kinase (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
PKC subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
10022904
uniprot
proteins
pubmed
10747026
uniprot
proteins
pubmed
11158308
uniprot
proteins
pubmed
11525734
uniprot
proteins
pubmed
11914719
uniprot
proteins
pubmed
12431995
uniprot
proteins
pubmed
12813044
uniprot
proteins
pubmed
12857744
uniprot
proteins
pubmed
14580237
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2470089
uniprot
proteins
pubmed
27498875
uniprot
proteins
pubmed
2834397
uniprot
proteins
pubmed
3691811
uniprot
proteins
pubmed
8378304
uniprot
proteins
pubmed
8557035
uniprot
proteins
pubmed
9177193
uniprot
proteins
pubmed
9374484
uniprot
proteins
sequence_length
592
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12431995, ECO:0000269|PubMed:8378304, ECO:0000269|PubMed:9177193}. Endosome {ECO:0000250|UniProtKB:Q05513}. Cell junction {ECO:0000250|UniProtKB:Q05513}. Membrane {ECO:0000269|PubMed:8378304}; Peripheral membrane protein {ECO:0000305}. Note=In the retina, localizes in the terminals of the rod bipolar cells (PubMed:12431995). Associated with endosomes (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction (By similarity). Colocalizes with VAMP2 and WDFY2 in intracellular vesicles (By similarity). Transiently translocates to the membrane of CA1 hippocampal cells in response to the induction of long term potentiation (PubMed:8378304). {ECO:0000250|UniProtKB:Q05513, ECO:0000269|PubMed:12431995, ECO:0000269|PubMed:8378304}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:8378304}.
uniprot
proteins