Dlg4
entrez
29495
canonical
uniprot
P31016
canonical
ensembl
ENSRNOG00000018526
resolver
ensp
ENSRNOP00000079351
resolver
ensp
ENSRNOP00000080177
resolver
ensp
ENSRNOP00000080495
resolver
enst
ENSRNOT00000099685
resolver
genesymbol
Dlg4
resolver
genesymbol_syn
Dlgh4
resolver
genesymbol_syn
Psd95
resolver
uniprot
A0A8I5ZQU2
resolver
uniprot
P97631
resolver
uniprot_entry
A0A8I5ZQU2_RAT
resolver
uniprot_entry
DLG4_RAT
resolver
uniprot_sec
P97631
resolver
amino_acid_sequence
MDCLCIVTTKKYRYQDEDTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKVAKPSNAYLSDSYAPPDITTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPKRGFYIRALFDYDKTKDCGFLSQALSFRFGDVLHVIDAGDEEWWQARRVHSDSETDDIGFIPSKRRVERREWSRLKAKDWGSSSGSQGREDSVLSYETVTQMEVHYARPIIILGPTKDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSREKMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIAIFIRPRSLENVLEINKRITEEQARKAFDRATKLEQEFTECFSAIVEGDSFEEIYHKVKRVIEDLSGPYIWVPARERL
uniprot
proteins
function
FUNCTION: Postsynaptic scaffolding protein that plays a critical role in synaptogenesis and synaptic plasticity by providing a platform for the postsynaptic clustering of crucial synaptic proteins (PubMed:15317815, PubMed:15358863, PubMed:19596852, PubMed:20628354, PubMed:23300088, PubMed:26679993). Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity). Also regulates AMPA-type glutamate receptor (AMPAR) immobilization at postsynaptic density keeping the channels in an activated state in the presence of glutamate and preventing synaptic depression (PubMed:19596852). Under basal conditions, cooperates with FYN to stabilize palmitoyltransferase ZDHHC5 at the synaptic membrane through FYN-mediated phosphorylation of ZDHHC5 and its subsequent inhibition of association with endocytic proteins (By similarity). {ECO:0000250|UniProtKB:P78352, ECO:0000250|UniProtKB:Q62108, ECO:0000269|PubMed:15317815, ECO:0000269|PubMed:15358863, ECO:0000269|PubMed:19596852, ECO:0000269|PubMed:20628354, ECO:0000269|PubMed:23300088, ECO:0000269|PubMed:26679993}.
uniprot
proteins
mass_dalton
80465
uniprot
proteins
mutagenesis
MUTAGEN 3; /note="C->S: Loss of palmitoylation and targeting to postsynaptic density."; /evidence="ECO:0000269|PubMed:10629226, ECO:0000269|PubMed:27307232"; MUTAGEN 5; /note="C->S: Loss of palmitoylation and targeting to postsynaptic density."; /evidence="ECO:0000269|PubMed:10629226, ECO:0000269|PubMed:27307232"; MUTAGEN 13..24; /note="Missing: Greatly reduced ubiquitination."; /evidence="ECO:0000269|PubMed:14642282
uniprot
proteins
post_translational_modification
PTM: Palmitoylated (PubMed:10629226, PubMed:27307232). Palmitoylation is required for targeting to postsynaptic density, plasma membrane and synapses (PubMed:10629226, PubMed:27307232). Palmitoylation by ZDHHC2 occurs when the synaptic activity decreases and induces DLG4 synaptic clustering (PubMed:19596852). Palmitoylation by ZDHHC15 regulates trafficking to the postsynaptic density and function in synaptogenesis (PubMed:15603741, PubMed:31189538). Palmitoylation may play a role in glutamate receptor GRIA1 synapse clustering (PubMed:27307232). Depalmitoylated by ABHD17A and ABHD17B and to a lesser extent by ABHD17C, ABHD12, ABHD13, LYPLA1 and LYPLA2 (PubMed:27307232). Undergoes rapid synaptic palmitoylation/depalmitoylation cycle during neuronal development which slows down in mature neurons (PubMed:27307232). {ECO:0000269|PubMed:10629226, ECO:0000269|PubMed:15603741, ECO:0000269|PubMed:19596852, ECO:0000269|PubMed:27307232, ECO:0000269|PubMed:31189538}.; PTM: Ubiquitinated by MDM2 in response to NMDA receptor activation, leading to proteasome-mediated degradation of DLG4 which is required for AMPA receptor endocytosis. {ECO:0000269|PubMed:14642282}.
uniprot
proteins
protein_family
MAGUK family
uniprot
proteins
pubmed
10623522
uniprot
proteins
pubmed
10629226
uniprot
proteins
pubmed
11134026
uniprot
proteins
pubmed
11483650
uniprot
proteins
pubmed
11502259
uniprot
proteins
pubmed
11779504
uniprot
proteins
pubmed
11779506
uniprot
proteins
pubmed
11923279
uniprot
proteins
pubmed
11997254
uniprot
proteins
pubmed
12151521
uniprot
proteins
pubmed
1419001
uniprot
proteins
pubmed
14642282
uniprot
proteins
pubmed
15123241
uniprot
proteins
pubmed
15304526
uniprot
proteins
pubmed
15317815
uniprot
proteins
pubmed
15358863
uniprot
proteins
pubmed
15603741
uniprot
proteins
pubmed
15629447
uniprot
proteins
pubmed
16054660
uniprot
proteins
pubmed
16495444
uniprot
proteins
pubmed
16630835
uniprot
proteins
pubmed
16990550
uniprot
proteins
pubmed
17334360
uniprot
proteins
pubmed
19072119
uniprot
proteins
pubmed
19118189
uniprot
proteins
pubmed
19596852
uniprot
proteins
pubmed
20089912
uniprot
proteins
pubmed
20628354
uniprot
proteins
pubmed
20962234
uniprot
proteins
pubmed
21119615
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23300088
uniprot
proteins
pubmed
26679993
uniprot
proteins
pubmed
27307232
uniprot
proteins
pubmed
27458189
uniprot
proteins
pubmed
27756895
uniprot
proteins
pubmed
30021165
uniprot
proteins
pubmed
31189538
uniprot
proteins
pubmed
7569905
uniprot
proteins
pubmed
7680343
uniprot
proteins
pubmed
8674113
uniprot
proteins
pubmed
8922396
uniprot
proteins
pubmed
9115257
uniprot
proteins
pubmed
9581761
uniprot
proteins
pubmed
9581762
uniprot
proteins
pubmed
9756850
uniprot
proteins
pubmed
9786987
uniprot
proteins
sequence_length
724
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10629226, ECO:0000269|PubMed:14642282, ECO:0000269|PubMed:9115257, ECO:0000305|PubMed:11997254}; Lipid-anchor {ECO:0000269|PubMed:10629226}; Cytoplasmic side {ECO:0000269|PubMed:10629226}. Postsynaptic density {ECO:0000269|PubMed:10629226, ECO:0000269|PubMed:11483650, ECO:0000269|PubMed:26679993, ECO:0000269|PubMed:27307232, ECO:0000269|PubMed:27756895, ECO:0000269|PubMed:9115257}. Synapse {ECO:0000269|PubMed:11483650, ECO:0000269|PubMed:11502259, ECO:0000269|PubMed:14642282, ECO:0000269|PubMed:19596852, ECO:0000269|PubMed:20089912, ECO:0000269|PubMed:20962234, ECO:0000269|PubMed:27307232, ECO:0000269|PubMed:8922396, ECO:0000269|PubMed:9115257}. Cytoplasm {ECO:0000269|PubMed:9115257}. Cell projection, axon {ECO:0000269|PubMed:20089912, ECO:0000269|PubMed:8922396}. Cell projection, dendritic spine {ECO:0000269|PubMed:10629226, ECO:0000269|PubMed:20628354, ECO:0000269|PubMed:26679993, ECO:0000269|PubMed:30021165}. Cell projection, dendrite {ECO:0000269|PubMed:10629226, ECO:0000269|PubMed:11483650}. Presynapse {ECO:0000269|PubMed:8922396}. Note=High levels in postsynaptic density of neurons in the forebrain. Also in presynaptic region of inhibitory synapses formed by cerebellar basket cells on axon hillocks of Purkinje cells. Suppression of neuronal activity induces synaptic accumulation and clustering of DLG4 (PubMed:19596852). {ECO:0000269|PubMed:19596852, ECO:0000269|PubMed:8922396}.
uniprot
proteins