Myog
entrez
17928
canonical
uniprot
P12979
canonical
ensembl
ENSMUSG00000026459
resolver
ensp
ENSMUSP00000027730
resolver
enst
ENSMUST00000027730
resolver
genesymbol
Myog
resolver
uniprot_entry
MYOG_MOUSE
resolver
amino_acid_sequence
MELYETSPYFYQEPHFYDGENYLPVHLQGFEPPGYERTELSLSPEARGPLEEKGLGTPEHCPGQCLPWACKVCKRKSVSVDRRRAATLREKRRLKKVNEAFEALKRSTLLNPNQRLPKVEILRSAIQYIERLQALLSSLNQEERDLRYRGGGGPQPMVPSECNSHSASCSPEWGNALEFGPNPGDHLLAADPTDAHNLHSLTSIVDSITVEDMSVAFPDETMPN
uniprot
proteins
function
FUNCTION: Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation, cell cycle exit and muscle atrophy. Essential for the development of functional embryonic skeletal fiber muscle differentiation. However is dispensable for postnatal skeletal muscle growth; phosphorylation by CAMK2G inhibits its transcriptional activity in respons to muscle activity. Required for the recruitment of the FACT complex to muscle-specific promoter regions, thus promoting gene expression initiation. During terminal myoblast differentiation, plays a role as a strong activator of transcription at loci with an open chromatin structure previously initiated by MYOD1. Together with MYF5 and MYOD1, co-occupies muscle-specific gene promoter core regions during myogenesis. Also cooperates with myocyte-specific enhancer factor MEF2D and BRG1-dependent recruitment of SWI/SNF chromatin-remodeling enzymes to alter chromatin structure at myogenic late gene promoters. Facilitates cell cycle exit during terminal muscle differentiation through the up-regulation of miR-20a expression, which in turn represses genes involved in cell cycle progression. Binds to the E-box containing (E1) promoter region of the miR-20a gene. Also plays a role in preventing reversal of muscle cell differentiation. Contributes to the atrophy-related gene expression in adult denervated muscles. Induces fibroblasts to differentiate into myoblasts. {ECO:0000269|PubMed:15706034, ECO:0000269|PubMed:16407395, ECO:0000269|PubMed:16424906, ECO:0000269|PubMed:16437161, ECO:0000269|PubMed:21465538, ECO:0000269|PubMed:21798092, ECO:0000269|PubMed:22235349, ECO:0000269|PubMed:22847234, ECO:0000269|PubMed:23364797, ECO:0000269|PubMed:8393145, ECO:0000269|PubMed:8393146}.
uniprot
proteins
mass_dalton
25203
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CAMK2G on threonine and serine amino acids in a muscle activity-dependent manner. Phosphorylation of Thr-87 impairs both DNA-binding and trans-activation functions in contracting muscles (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
12196028
uniprot
proteins
pubmed
1324403
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15706034
uniprot
proteins
pubmed
16407395
uniprot
proteins
pubmed
16424906
uniprot
proteins
pubmed
16437161
uniprot
proteins
pubmed
1705035
uniprot
proteins
pubmed
21465538
uniprot
proteins
pubmed
2168405
uniprot
proteins
pubmed
2172083
uniprot
proteins
pubmed
21798092
uniprot
proteins
pubmed
22235349
uniprot
proteins
pubmed
22847234
uniprot
proteins
pubmed
23364797
uniprot
proteins
pubmed
2473006
uniprot
proteins
pubmed
2552320
uniprot
proteins
pubmed
7929574
uniprot
proteins
pubmed
8393145
uniprot
proteins
pubmed
8393146
uniprot
proteins
sequence_length
224
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:16424906}. Note=Recruited to late myogenic gene promoter regulatory sequences with SMARCA4/BRG1/BAF190A and SWI/SNF chromatin-remodeling enzymes to promote chromatin-remodeling and transcription initiation in developing embryos.
uniprot
proteins