Dnmt3c
entrez
668932
canonical
uniprot
P0DOY1
canonical
ensembl
ENSMUSG00000082079
resolver
ensp
ENSMUSP00000153622
resolver
enst
ENSMUST00000119996
resolver
genesymbol
Dnmt3c
resolver
genesymbol_syn
Gm14490
resolver
uniprot
A0A286YDX7
resolver
uniprot_entry
DNM3C_MOUSE
resolver
uniprot_sec
A0A286YDX7
resolver
amino_acid_sequence
MRGGSRHLSNEEDVSGCEDCIIISGTCSDQSSDPKTVPLTQVLEAVCTVENRGCRTSSQPSKRKASSLISYVQDLTGDGDEDRDGEVGGSSGSGTPVMPQLFCETRIPSKTPAPLSWQANTSASTPWLSPASPYPIIDLTDEDVIPQSISTPSVDWSQDSHQEGMDTTQVDAESRDGGNIEYQVSADKLLLSQSCILAAFYKLVPYRESIYRTLEKARVRAGKACPSSPGESLEDQLKPMLEWAHGGFKPTGIEGLKPNKKQPENKSRRRTTNDPAASESSPPKRLKTNSYGGKDRGEDEESREQMASDVTNNKGNLEDHCLSCGRKDPVSFHPLFEGGLCQSCRDRFLELFYMYDEDGYQSYCTVCCEGRELLLCSNTSCCRCFCVECLEVLVGAGTAEDVKLQEPWSCYMCLPQRCHGVLRRRKDWNMRLQDFFTTDPDLEEFEPPKLYPAIPAAKRRPIRVLSLFDGIATGYLVLKELGIKVEKYIASEVCAESIAVGTVKHEGQIKYVDDIRNITKEHIDEWGPFDLVIGGSPCNDLSCVNPVRKGLFEGTGRLFFEFYRLLNYSCPEEEDDRPFFWMFENVVAMEVGDKRDISRFLECNPVMIDAIKVSAAHRARYFWGNLPGMNRPVMASKNDKLELQDCLEFSRTAKLKKVQTITTKSNSIRQGKNQLFPVVMNGKDDVLWCTELERIFGFPEHYTDVSNMGRGARQKLLGRSWSVPVIRHLFAPLKDHFACE
uniprot
proteins
ec_number
2.1.1.37
uniprot
proteins
function
FUNCTION: DNA methyltransferase that specifically methylates the promoters of evolutionarily young retrotransposons in the male germline (PubMed:27856912, PubMed:28854222, PubMed:38359823, PubMed:39098534). De novo methylation and subsequent repression of transposable elements prevents their mobilization, which is essential for germline integrity (PubMed:27856912, PubMed:28854222, PubMed:38359823). Compared to Dnmt3a and Dnmt3b, shows lower DNA methyltransferase efficiency (PubMed:39098534). {ECO:0000269|PubMed:27856912, ECO:0000269|PubMed:28854222, ECO:0000269|PubMed:38359823, ECO:0000269|PubMed:39098534}.
uniprot
proteins
mass_dalton
82921
uniprot
proteins
mutagenesis
MUTAGEN 538; /note="C->A: Loss of methyltransferase activity."; /evidence="ECO:0000269|PubMed:27856912"; MUTAGEN 543; /note="C->I,N: Decreased DNA methyltransferase efficiency."; /evidence="ECO:0000269|PubMed:39098534"; MUTAGEN 590; /note="E->G,K: Increased DNA methyltransferase efficiency."; /evidence="ECO:0000269|PubMed:39098534"; MUTAGEN 693; /note="E->G: In rahu mutant; male sterility due to defects in spermatogenesis, probably caused by transposon derepression due to impaired DNA demethylation. Abolished homodimerization and DNA-binding."; /evidence="ECO:0000269|PubMed:28854222, ECO:0000269|PubMed:39098534
uniprot
proteins
protein_family
C5-methyltransferase family
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
27856912
uniprot
proteins
pubmed
28854222
uniprot
proteins
pubmed
32674113
uniprot
proteins
pubmed
38359823
uniprot
proteins
pubmed
39098534
uniprot
proteins
sequence_length
740
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:38359823}.
uniprot
proteins