Steap4
entrez
117167
canonical
uniprot
Q923B6
canonical
ensembl
ENSMUSG00000012428
resolver
ensp
ENSMUSP00000111081
resolver
enst
ENSMUST00000115421
resolver
genesymbol
Steap4
resolver
genesymbol_syn
Tiarp
resolver
uniprot
Q91W31
resolver
uniprot
Q91ZE8
resolver
uniprot_entry
STEA4_MOUSE
resolver
uniprot_sec
Q91W31
resolver
uniprot_sec
Q91ZE8
resolver
amino_acid_sequence
MEKAHADEFPLTTDSSEKQGVVCIFGTGDFGKSLGLKMLQCGYSIVFGSRNPQVSSLLPRGAEVLSYSEAASKSDIIILAMHREHYDSLTELVDYLKGKVLVDVSNNRKINQYPESNAEYLAQLEPGAHVVKAFNTISAWALQSGTLDASRQVFVCGNDSKAKQRVMDIARTLGLTPLDQGSLMAASEIENYPLQLFPMWRFPFYLSSVLCVFFFVYCAIREVIYPYVNGKTDATYRLAISIPNRVFPITALILLALVYLPGILAAILQLYRGTKYRRFPNWLDHWMLCRKQLGLVALGFAFLHVIYTLVIPIRYYVRWRLRNATITQALTNKDSPFITSYAWINDSYLALGILGFFLFLLLGITSLPSVSNMVNWREFRFVQSKLGYLTLVLCTAHTLVYGGKRFLSPSILRWSLPSAYILALVIPCAVLVLKCILIMPCIDKTLTRIRQGWERNSKYTQSALNGKSDI
uniprot
proteins
ec_number
1.16.1.-
uniprot
proteins
function
FUNCTION: Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (PubMed:16609065). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (PubMed:16609065). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (PubMed:17482547). Associated with obesity and insulin-resistance (By similarity). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed:19660107). Inhibits anchorage-independent cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q687X5, ECO:0000269|PubMed:16609065, ECO:0000269|PubMed:17482547, ECO:0000269|PubMed:19660107}.
uniprot
proteins
mass_dalton
52994
uniprot
proteins
protein_family
STEAP family
uniprot
proteins
pubmed
11443137
uniprot
proteins
pubmed
14988015
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16609065
uniprot
proteins
pubmed
17482547
uniprot
proteins
pubmed
19289123
uniprot
proteins
pubmed
19660107
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
470
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11443137, ECO:0000269|PubMed:16609065}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q687X5}. Golgi apparatus membrane {ECO:0000305|PubMed:11443137}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q687X5}. Early endosome membrane {ECO:0000269|PubMed:16609065}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q687X5}.
uniprot
proteins
transmembrane_region
TRANSMEM 202..224; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q687X5"; TRANSMEM 236..256; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q687X5"; TRANSMEM 293..313; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q687X5"; TRANSMEM 342..362; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q687X5"; TRANSMEM 381..401; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q687X5"; TRANSMEM 419..439; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q687X5
uniprot
proteins