Letmd1
entrez
68614
canonical
uniprot
Q924L1
canonical
ensembl
ENSMUSG00000037353
resolver
ensp
ENSMUSP00000037546
resolver
ensp
ENSMUSP00000155084
resolver
ensp
ENSMUSP00000155807
resolver
ensp
ENSMUSP00000221244
resolver
genesymbol
Letmd1
resolver
genesymbol_syn
Mccr
resolver
uniprot
Q3TF05
resolver
uniprot
Q3U3M7
resolver
uniprot
Q8BLG9
resolver
uniprot
Q8K1F7
resolver
uniprot
Q8VDS9
resolver
uniprot_entry
LTMD1_MOUSE
resolver
uniprot_sec
Q3TF05
resolver
uniprot_sec
Q3U3M7
resolver
uniprot_sec
Q8BLG9
resolver
uniprot_sec
Q8K1F7
resolver
uniprot_sec
Q8VDS9
resolver
amino_acid_sequence
MALSRVCWARAALWGSTVAPGPFVTRRLQLGRSGPAWRAPRSSKLHLSPKADVKNLISYVVTKTRAINGSYHRFLGRHFPRFYALYTTFMKGIQMLWADGKKARRIKADMWKQNLKFHQLSYREMEHLRQFRRDITKCLFVGLISIPPFANYLVFLLMYLFPRQLLVKHFWTPKQQIDFLDVYHGLRRRSHSEVITHLRRASTFVSHEKLRRQLTDLCTKVQSGTHPAAQDVLALRDCFSTYPLGFSQLQASQMRALSQAMLLTPYLPPPLLRQRLKSHTTVIHQLDRALAKLGIGQLTAQEVKSACYLRGLNSTHIADDRCRAWLGEWLHISCSLKEPELSLLLHNVVLLSTNYLETRR
uniprot
proteins
function
FUNCTION: Plays an essential role for mitochondrial structure and function, as well as thermogenesis of brown adipocytes (PubMed:34669999, PubMed:34910916, PubMed:36334589). In brown adipose tissue also localizes in the nucleus where it interacts with the chromatin remodeler SMARCA4 to regulate thermogenic genes expression, such as UCP1 (PubMed:34910916). May regulate phagocytosis and inflammatory responses to lipopolysaccharide in macrophages (By similarity). Involved in tumorigenesis and may function as a negative regulator of the p53/TP53 (PubMed:12879013). {ECO:0000250|UniProtKB:Q6P1Q0, ECO:0000269|PubMed:12879013, ECO:0000269|PubMed:34669999, ECO:0000269|PubMed:34910916, ECO:0000269|PubMed:36334589}.
uniprot
proteins
mass_dalton
41701
uniprot
proteins
pubmed
12879013
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
34669999
uniprot
proteins
pubmed
34910916
uniprot
proteins
pubmed
36334589
uniprot
proteins
sequence_length
360
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q6P1Q0}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q6P1Q0}. Nucleus {ECO:0000269|PubMed:34910916}. Mitochondrion inner membrane {ECO:0000269|PubMed:36334589}; Single-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 138..158; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins