HCAR2
entrez
338442
canonical
uniprot
Q8TDS4
canonical
ensembl
ENSG00000182782
resolver
ensp
ENSP00000375066
resolver
enst
ENST00000328880
resolver
genesymbol
HCAR2
resolver
genesymbol_syn
GPR109A
resolver
genesymbol_syn
HCA2
resolver
genesymbol_syn
HM74A
resolver
genesymbol_syn
NIACR1
resolver
hgnc
HGNC:24827
resolver
uniprot
A0PJL5
resolver
uniprot
A7LGG3
resolver
uniprot_entry
HCAR2_HUMAN
resolver
uniprot_sec
A0PJL5
resolver
uniprot_sec
A7LGG3
resolver
amino_acid_sequence
MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSFSICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGPTSP
uniprot
proteins
function
FUNCTION: Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide. {ECO:0000269|PubMed:17932499}.
uniprot
proteins
mass_dalton
41850
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12044878
uniprot
proteins
pubmed
12522134
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17932499
uniprot
proteins
pubmed
21454438
uniprot
proteins
sequence_length
363
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17932499}; Multi-pass membrane protein {ECO:0000269|PubMed:17932499}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..54; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 64..84; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 103..123; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 143..163; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 193..213; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 230..250; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 274..294; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins