Rab2a
entrez
59021
canonical
uniprot
P53994
canonical
ensembl
ENSMUSG00000047187
resolver
ensp
ENSMUSP00000057664
resolver
ensp
ENSMUSP00000365080
resolver
enst
ENSMUST00000060232
resolver
genesymbol
Rab2a
resolver
genesymbol_syn
Rab2
resolver
genesymbol_syn
Rab2A
resolver
uniprot
Q0PD65
resolver
uniprot
Q3UK45
resolver
uniprot_entry
Q0PD65_MOUSE
resolver
uniprot_entry
RAB2A_MOUSE
resolver
uniprot_sec
Q3UK45
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors (GDIs) which inhibit the dissociation of the nucleotide from the GTPase. {ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MAYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRDTFNHLTTWLEDARQHSNSNMVIMLIGNKSDLESRREVKKEEGEAFAREHGLIFMETSAKTASNVEEAFINTAKEIYEKIQEGVFDINNEANGIKIGPQHAATNASHGSNQGGQQAGGGCC
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology (Probable) (PubMed:28063257). RAB2A regulates autophagy by promoting autophagosome-lysosome fusion via recruitment of the HOPS endosomal tethering complex; this process involves autophagosomal RAB2A and lysosomal RAB39A recruitment of HOPS subcomplexes VPS39-VPS11 and VPS41-VPS16-VPS18-VPS33A, respectively, which assemble into a functional complex to mediate membrane tethering and SNAREs-driven membrane fusion (By similarity). Required for protein transport from the endoplasmic reticulum to the Golgi complex. Regulates the compacted morphology of the Golgi (By similarity). Together with RAB2B, redundantly required for efficient autophagic flux (PubMed:28063257). {ECO:0000250|UniProtKB:P61019, ECO:0000269|PubMed:28063257, ECO:0000305|PubMed:34714330}.
uniprot
proteins
mass_dalton
23548
uniprot
proteins
mutagenesis
MUTAGEN 20; /note="S->N: Constitutively inactive. Loss of interaction with GARIN1B."; /evidence="ECO:0000269|PubMed:34714330"; MUTAGEN 65; /note="Q->L: Constitutively active. Interacts with GARIN1B."; /evidence="ECO:0000269|PubMed:34714330
uniprot
proteins
post_translational_modification
PTM: Prenylated. Prenylation is required for association with cellular membranes. {ECO:0000250|UniProtKB:P61019}.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28063257
uniprot
proteins
pubmed
34714330
uniprot
proteins
sequence_length
212
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate compartment membrane; Lipid-anchor {ECO:0000250|UniProtKB:P61019}; Cytoplasmic side {ECO:0000305}. Melanosome {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000305}; Lipid-anchor {ECO:0000250|UniProtKB:P61019}; Cytoplasmic side {ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:34714330}; Lipid-anchor {ECO:0000250|UniProtKB:P61019}; Cytoplasmic side {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:34714330}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000269|PubMed:28063257}; Lipid-anchor {ECO:0000250|UniProtKB:P61019}; Cytoplasmic side {ECO:0000305}. Note=Localized in the Golgi apparatus in the round spermatids and in the acrosome in the elongating spermatid. {ECO:0000269|PubMed:34714330}.
uniprot
proteins