Pde6b
entrez
18587
canonical
uniprot
P23440
canonical
ensembl
ENSMUSG00000029491
resolver
ensp
ENSMUSP00000031456
resolver
genesymbol
Pde6b
resolver
genesymbol_syn
Mpb
resolver
genesymbol_syn
Pdeb
resolver
genesymbol_syn
rd
resolver
uniprot
Q80UF0
resolver
uniprot_entry
PDE6B_MOUSE
resolver
uniprot_sec
Q80UF0
resolver
amino_acid_sequence
MSLSEEQVRSFLDGNPTFAHQYFGKKLSPENVAGACEDGWLADCGSLRELCQVEESAALFELVQDMQESVNMERVVFKILRRLCTILHADRCSLFMYRQRNGIAELATRLFSVQPDSLLEDCLVPPDSEIVFPLDIGIVGHVAQTKKMINVQDVAECPHFSSFADELTDYVTKNILSTPIMNGKDVVAVIMAVNKLDGPCFTSEDEDVFTKYLNFATLNLKIYHLSYLHNCETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWPVLMGEAQPYSGPRTPDGREIVFYKVIDYILHGKEDIKVIPTPPADHWALASGLPTYVAESGFICNIMNASADEMFNFQEGPLDDSGWVIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDDQDEVLMESLTQFLGWSVLNTDTYDKMNKLENRKDIAQDMVLYHVRCDKDEIQEILPTRDRLGKEPADCEEDELGKILKEELPGPTKFDIYEFHFSDLECTELELVKCGIQMYYELGVVRKFQIPQEVLVRFLFSVSKAYRRITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAKLHGSSILERHHLEFGKFLLAEESLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRTMFQKIVDESKNYEDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADEYEAKVKALEEEKKKEEDRVAAKKVGTEVCNGGPAPKSSTCCIL
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Pde6b are the cause of the retinal degeneration (rd) allele, which is characterized by retinal degeneration (PubMed:1656438, PubMed:1977087). The retinal degeneration 1 (rd1) allele also contains a cofounding mutation in the Gpr179 gene (PubMed:25613321). {ECO:0000269|PubMed:1656438, ECO:0000269|PubMed:1977087, ECO:0000269|PubMed:25613321}.
uniprot
proteins
ec_number
3.1.4.35
uniprot
proteins
function
FUNCTION: Catalytic beta subunit of the rod-specific cGMP phosphodiesterase (PDE6) complex, which hydrolyzes 3',5'-cyclic GMP in the phototransduction cascade (By similarity). The PDE6 holoenzyme consists of two catalytic subunits (PDE6A and PDE6B) and two inhibitory gamma subunits (PDE6G) (PubMed:1847109). Light-activated GNAT1 relieves gamma subunit-mediated inhibition, enabling the catalytic subunits to hydrolyze cGMP and thereby mediate visual signal transduction and amplification. Decreased cytosolic cGMP levels result in closure of cGMP-gated cation channels at the plasma membrane, leading to rod photoreceptor hyperpolarization (By similarity). Involved in retinal circadian rhythm photoentrainment via modulation of UVA and orange light-induced phase-shift of the retina clock (PubMed:30240620). {ECO:0000250|UniProtKB:P35913, ECO:0000269|PubMed:1847109, ECO:0000269|PubMed:30240620}.
uniprot
proteins
mass_dalton
98535
uniprot
proteins
post_translational_modification
PTM: Geranylgeranylated. This modification is required for association with the rod photoreceptor disk membrane. {ECO:0000250|UniProtKB:D3ZDI8}.
uniprot
proteins
protein_family
Cyclic nucleotide phosphodiesterase family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1656438
uniprot
proteins
pubmed
1847109
uniprot
proteins
pubmed
1977087
uniprot
proteins
pubmed
25613321
uniprot
proteins
pubmed
30240620
uniprot
proteins
sequence_length
856
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Photoreceptor outer segment membrane {ECO:0000250|UniProtKB:P35913}; Lipid-anchor {ECO:0000250|UniProtKB:D3ZDI8}. Membrane {ECO:0000250|UniProtKB:P23439}; Lipid-anchor {ECO:0000250|UniProtKB:D3ZDI8}.
uniprot
proteins