Kdm2a
entrez
225876
canonical
uniprot
P59997
canonical
ensembl
ENSMUSG00000054611
resolver
ensp
ENSMUSP00000047683
resolver
ensp
ENSMUSP00000076698
resolver
enst
ENSMUST00000047898
resolver
enst
ENSMUST00000075856
resolver
genesymbol
Kdm2a
resolver
genesymbol_syn
Fbl11
resolver
genesymbol_syn
Fbxl11
resolver
genesymbol_syn
Jhdm1a
resolver
genesymbol_syn
Kiaa1004
resolver
uniprot
F6YRW4
resolver
uniprot
Q3U1M5
resolver
uniprot
Q3UR56
resolver
uniprot
Q3V3Q1
resolver
uniprot
Q69ZT4
resolver
uniprot_entry
F6YRW4_MOUSE
resolver
uniprot_entry
KDM2A_MOUSE
resolver
uniprot_sec
Q3U1M5
resolver
uniprot_sec
Q3UR56
resolver
uniprot_sec
Q3V3Q1
resolver
uniprot_sec
Q69ZT4
resolver
amino_acid_sequence
MEPEEERIRYSQRLRGTMRRRYEDDGISDDEIEGKRTFDLEEKLQTNKYNANFVTFMEGKDFNVEYIQRGGLRDPLIFKNSDGLGIKMPDPDFTVNDVKMCVGSRRMVDVMDVNTQKGIEMTMAQWTRYYETPEEEREKLYNVISLEFSHTRLENMVQWPSTVDFIDWVDNMWPRHLKESQTESTNAILEMQYPKVQKYCLISVRGCYTDFHVDFGGTSVWYHIHQGGKVFWLIPPTAHNLELYENWLLSGKQGDIFLGDRVSDCQRIELKQGYTFVIPSGWIHAVYTPTDTLVFGGNFLHSFNIPMQLKIYSIEDRTRVPNKFRYPFYYEMCWYVLERYVYCITNRSHLTKDFQKESLSMDMELNELESGNGDEEGVDREARRMNNKRSVLTSPVANGVNLDYDGLGKACRSLPSLKKTLSGDSSSDSTRGSHNGQVWDPQCSPKKDRQVHLTHFELEGLRCLVDKLESLPLHKKCVPTGIEDEDALIADVKILLEELASSDPKLALTGVPIVQWPKRDKLKFPTRPKVRVPTIPITKPHTMKPAPRLTPVRPAAASPIVSGARRRRVRCRKCKACVQGECGVCHYCRDMKKFGGPGRMKQSCVLRQCLAPRLPHSVTCSLCGEVDQNEETQDFEKKLMECCICNEIVHPGCLQMDGEGLLNEELPNCWECPKCYQEDSSDKAQKRKIEESDEEAVQAKVLRPLRSCEEPLTPPPHSPTSMLQLIHDPVSPRGMVTRSSPGAGPSDHHSASRDERFKRRQLLRLQATERTMVREKENNPSGKKELSEVEKAKIRGSYLTVTLQRPTKELHGTSIVPKLQAITASSANLRPNPRVLMQHCPARNPQHGDEEGLGGEEEEEEEEEEDDSAEEGGAARLNGRGSWAQDGDESWMQREVWMSVFRYLSRKELCECMRVCKTWYKWCCDKRLWTKIDLSRCKAIVPQALSGIIKRQPVSLDLSWTNISKKQLTWLVNRLPGLKDLLLAGCSWSAVSALSTSSCPLLRTLDLRWAVGIKDPQIRDLLTPPTDKPGQDNRSKLRNMTDFRLAGLDITDATLRLIIRHMPLLSRLDLSHCSHLTDQSSNLLTAVGSSTRYSLTELNMAGCNKLTDQTLFFLRRIANVTLIDLRGCKQITRKACEHFISDLSINSLYCLSDEKLIQKIS
uniprot
proteins
ec_number
1.14.11.27
uniprot
proteins
function
FUNCTION: Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:32584788). Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis (By similarity). Regulates circadian gene expression by repressing the transcriptional activator activity of CLOCK-BMAL1 heterodimer and RORA in a catalytically-independent manner (By similarity). {ECO:0000250|UniProtKB:Q9Y2K7, ECO:0000269|PubMed:32584788}.
uniprot
proteins
mass_dalton
132680
uniprot
proteins
post_translational_modification
PTM: Mono-ADP-ribosylated at Arg-1019 in response to DNA damage, leading to displacement from chromatin, resulting in increased dimethylation of histone H3 at 'Lys-36'. {ECO:0000269|PubMed:32584788}.
uniprot
proteins
protein_family
JHDM1 histone demethylase family
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32584788
uniprot
proteins
pubmed
41951593
uniprot
proteins
sequence_length
1161
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9Y2K7}. Chromosome {ECO:0000269|PubMed:32584788}. Note=Punctate expression throughout the nucleoplasm and enriched in the perinucleolar region. Specifically nucleates at CpG islands where its presence results in chromatin depleted in H3K36me2 (By similarity). {ECO:0000250|UniProtKB:Q9Y2K7}.
uniprot
proteins