MVB12A
entrez
93343
canonical
uniprot
Q96EY5
canonical
ensembl
ENSG00000141971
resolver
ensp
ENSP00000324810
resolver
genesymbol
MVB12A
resolver
genesymbol_syn
CFBP
resolver
genesymbol_syn
FAM125A
resolver
hgnc
HGNC:25153
resolver
uniprot
Q96I18
resolver
uniprot_entry
MB12A_HUMAN
resolver
uniprot_sec
Q96I18
resolver
amino_acid_sequence
MDPVPGTDSAPLAGLAWSSASAPPPRGFSAISCTVEGAPASFGKSFAQKSGYFLCLSSLGSLENPQENVVADIQIVVDKSPLPLGFSPVCDPMDSKASVSKKKRMCVKLLPLGATDTAVFDVRLSGKTKTVPGYLRIGDMGGFAIWCKKAKAPRPVPKPRGLSRDMQGLSLDAASQPSKGGLLERTASRLGSRASTLRRNDSIYEASSLYGISAMDGVPFTLHPRFEGKSCSPLAFSAFGDLTIKSLADIEEEYNYGFVVEKTAAARLPPSVS
uniprot
proteins
function
FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor. {ECO:0000269|PubMed:16895919}.
uniprot
proteins
mass_dalton
28783
uniprot
proteins
mutagenesis
MUTAGEN 204; /note="Y->D: Mimics constitutively phosphorylated form and has the ability to interact with CD2AP and CIN85/SH3KBP1 without EGF treatment."; /evidence="ECO:0000269|PubMed:16895919"; MUTAGEN 204; /note="Y->F: Abolishes interaction with CD2AP and CIN85/SH3KBP1."; /evidence="ECO:0000269|PubMed:16895919
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Tyr-204 upon EGF stimulation. Phosphorylation is required for interaction with CD2AP and CIN85/SH3KBP1. {ECO:0000269|PubMed:16895919, ECO:0000269|PubMed:18005716}.
uniprot
proteins
protein_family
MVB12 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16895919
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17853893
uniprot
proteins
pubmed
18005716
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
273
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Endosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Late endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Colocalizes with F-actin. Some fraction may be nuclear.
uniprot
proteins