Dgat2
entrez
67800
canonical
uniprot
Q9DCV3
canonical
ensembl
ENSMUSG00000030747
resolver
ensp
ENSMUSP00000033001
resolver
enst
ENSMUST00000033001
resolver
genesymbol
Dgat2
resolver
uniprot_entry
DGAT2_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by niacin. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MKTLIAAYSGVLRGERRAEAARSENKNKGSALSREGSGRWGTGSSILSALQDIFSVTWLNRSKVEKQLQVISVLQWVLSFLVLGVACSVILMYTFCTDCWLIAVLYFTWLAFDWNTPKKGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYIFGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLAGNFRMPVLREYLMSGGICPVNRDTIDYLLSKNGSGNAIIIVVGGAAESLSSMPGKNAVTLKNRKGFVKLALRHGADLVPTYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCIFHGRGLFSSDTWGLVPYSKPITTVVGEPITVPKLEHPTQKDIDLYHAMYMEALVKLFDNHKTKFGLPETEVLEVN
uniprot
proteins
ec_number
2.3.1.20
uniprot
proteins
ec_number
2.3.1.76
uniprot
proteins
function
FUNCTION: Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides. Also functions as an acyl-CoA retinol acyltransferase (ARAT) (By similarity). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (By similarity). {ECO:0000250|UniProtKB:Q96PD7, ECO:0000269|PubMed:11481335, ECO:0000269|PubMed:15797871, ECO:0000269|PubMed:21680734, ECO:0000269|PubMed:22493088}.
uniprot
proteins
mass_dalton
43770
uniprot
proteins
pathway_participation
PATHWAY: Glycerolipid metabolism; triacylglycerol biosynthesis.
uniprot
proteins
protein_family
Diacylglycerol acyltransferase family
uniprot
proteins
pubmed
11481335
uniprot
proteins
pubmed
12413942
uniprot
proteins
pubmed
14521909
uniprot
proteins
pubmed
14668353
uniprot
proteins
pubmed
15258194
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15797871
uniprot
proteins
pubmed
15834126
uniprot
proteins
pubmed
16001399
uniprot
proteins
pubmed
16106050
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17035227
uniprot
proteins
pubmed
21680734
uniprot
proteins
pubmed
22493088
uniprot
proteins
pubmed
23066022
uniprot
proteins
sequence_length
388
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q96PD7}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96PD7}. Lipid droplet {ECO:0000250|UniProtKB:Q96PD7}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q96PD7}.
uniprot
proteins
transmembrane_region
TRANSMEM 70..88; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 93..112; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins