Pigx
entrez
288041
canonical
uniprot
Q60GF7
canonical
ensembl
ENSRNOG00000033623
resolver
ensp
ENSRNOP00000042305
resolver
genesymbol
Pigx
resolver
uniprot_entry
PIGX_RAT
resolver
amino_acid_sequence
MAASALAWLLLWAAGLVGRLAADISDARFSDGVRATCSEIILRQEFLKDGFHRDLLIKVKFGESIEDLQTCRLLIKHYIPTGLFVDPYELASLRERNITEAVMVSESFNLEAPNYLSTESAVLIYARQDAQCIDCFQAFLPVHYRYHRPHKKDGDTLIVVNNPDLLMHCDQEFPILKCWAQSEVAAPCSLKSEEICQWKNMQYKSILKNLTVQVPVGLTIHTSLVCSVTLLITVLCSTLILLAVFKYGHFSL
uniprot
proteins
function
FUNCTION: Stabilizing subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis (PubMed:15635094). Probably acts by stabilizing the mannosyltransferase PIGM (PubMed:15635094). {ECO:0000269|PubMed:15635094}.
uniprot
proteins
mass_dalton
28423
uniprot
proteins
pathway_participation
PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. {ECO:0000269|PubMed:15635094}.
uniprot
proteins
protein_family
PIGX family
uniprot
proteins
pubmed
15635094
uniprot
proteins
sequence_length
252
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15635094}; Single-pass type I membrane protein {ECO:0000269|PubMed:15635094}.
uniprot
proteins
transmembrane_region
TRANSMEM 225..245; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins