Tmem163
entrez
72160
canonical
uniprot
Q8C996
canonical
ensembl
ENSMUSG00000026347
resolver
ensp
ENSMUSP00000027585
resolver
ensp
ENSMUSP00000124307
resolver
ensp
ENSMUSP00000140828
resolver
enst
ENSMUST00000027585
resolver
enst
ENSMUST00000160616
resolver
enst
ENSMUST00000185560
resolver
genesymbol
Tmem163
resolver
genesymbol_syn
Sv31
resolver
uniprot
Q8C8I2
resolver
uniprot
Q9D0E0
resolver
uniprot_entry
TM163_MOUSE
resolver
uniprot_sec
Q8C8I2
resolver
uniprot_sec
Q9D0E0
resolver
amino_acid_sequence
MEPALGSERRSPPGPGVPRPPPRGHAPSTAAPAPSPAPMSSSVQSDEERQPRISESGQFSDGLEDRGLLESSTRLKPHEAQNYRKKALWVSWLSIIVTLALAVAAFTVSVMRYSASAFGFAFDAILDVLSSAIVLWRYSNAAAVHSANREYIACVILGVIFLLSSICIVVKAIHDLSTRLLPEVDDFLFSVSILSGILCSVLAVLKFMLGKVLTSRALITDGFNSLVGGVMGFSILLSAEVFKHNAAVWYLDGSIGVLIGLTIFAYGVKLLIDMVPRVRQTRHYEMFE
uniprot
proteins
function
FUNCTION: Zinc ion transporter that mediates zinc efflux and plays a crucial role in intracellular zinc homeostasis (By similarity). Binds the divalent cations Zn(2+), Ni(2+), and to a minor extent Cu(2+) (By similarity). Is a functional modulator of P2X purinoceptors, including P2RX1, P2RX3, P2RX4 and P2RX7 (By similarity). Plays a role in central nervous system development and is required for myelination, and survival and proliferation of oligodendrocytes (By similarity). {ECO:0000250|UniProtKB:A9CMA6, ECO:0000250|UniProtKB:B0UY98, ECO:0000250|UniProtKB:Q8TC26}.
uniprot
proteins
mass_dalton
31193
uniprot
proteins
protein_family
TMEM163 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
17623043
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25130899
uniprot
proteins
pubmed
31697912
uniprot
proteins
sequence_length
288
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:17623043}; Multi-pass membrane protein {ECO:0000255}. Early endosome membrane {ECO:0000250|UniProtKB:A9CMA6}; Multi-pass membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000250|UniProtKB:Q8TC26}; Multi-pass membrane protein {ECO:0000255}. Lysosome membrane {ECO:0000250|UniProtKB:Q8TC26}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q8TC26}; Multi-pass membrane protein {ECO:0000255}. Note=Glutamatergic synaptic vesicles. {ECO:0000250|UniProtKB:A9CMA6}.
uniprot
proteins
transmembrane_region
TRANSMEM 88..108; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 116..136; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 150..170; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 187..207; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 217..237; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 255..275; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins