S100A12
entrez
6283
canonical
uniprot
P80511
canonical
ensembl
ENSG00000163221
resolver
ensp
ENSP00000357726
resolver
enst
ENST00000368737
resolver
genesymbol
S100A12
resolver
hgnc
HGNC:10489
resolver
uniprot
P83219
resolver
uniprot
Q5SY66
resolver
uniprot
Q7M4R1
resolver
uniprot_entry
S10AC_HUMAN
resolver
uniprot_sec
P83219
resolver
uniprot_sec
Q5SY66
resolver
uniprot_sec
Q7M4R1
resolver
amino_acid_sequence
MTKLEEHLEGIVNIFHQYSVRKGHFDTLSKGELKQLLTKELANTIKNIKDKAVIDEIFQGLDANQDEQVDFQEFISLVAIALKAAHYHTHKE
uniprot
proteins
function
FUNCTION: S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its pro-inflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of pro-inflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus. {ECO:0000269|PubMed:11522286, ECO:0000269|PubMed:17208591, ECO:0000269|PubMed:18292089, ECO:0000269|PubMed:19386136}.
uniprot
proteins
mass_dalton
10575
uniprot
proteins
protein_family
S-100 family
uniprot
proteins
pubmed
11134923
uniprot
proteins
pubmed
11522286
uniprot
proteins
pubmed
12042313
uniprot
proteins
pubmed
12645006
uniprot
proteins
pubmed
12777802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17208591
uniprot
proteins
pubmed
18292089
uniprot
proteins
pubmed
18443896
uniprot
proteins
pubmed
1860454
uniprot
proteins
pubmed
19386136
uniprot
proteins
pubmed
19501594
uniprot
proteins
pubmed
19935766
uniprot
proteins
pubmed
20213444
uniprot
proteins
pubmed
20523765
uniprot
proteins
pubmed
22811950
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
7626002
uniprot
proteins
pubmed
8619860
uniprot
proteins
pubmed
8619876
uniprot
proteins
pubmed
8769108
uniprot
proteins
pubmed
8985590
uniprot
proteins
sequence_length
92
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22811950}. Cytoplasm {ECO:0000269|PubMed:22811950}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:22811950}. Cell membrane {ECO:0000269|PubMed:22811950}; Peripheral membrane protein {ECO:0000269|PubMed:22811950}. Note=Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation is secreted via a microtubule-mediated, alternative pathway.
uniprot
proteins