MYO1C
entrez
4641
canonical
uniprot
O00159
canonical
ensembl
ENSG00000197879
resolver
ensp
ENSP00000354283
resolver
ensp
ENSP00000437685
resolver
ensp
ENSP00000459174
resolver
ensp
ENSP00000459271
resolver
ensp
ENSP00000493973
resolver
ensp
ENSP00000496799
resolver
ensp
ENSP00000496954
resolver
enst
ENST00000545534
resolver
genesymbol
MYO1C
resolver
hgnc
HGNC:7597
resolver
uniprot
F5H6E2
resolver
uniprot
Q4LE56
resolver
uniprot
Q6NVJ7
resolver
uniprot
Q86Y95
resolver
uniprot_entry
F5H6E2_HUMAN
resolver
uniprot_entry
MYO1C_HUMAN
resolver
uniprot_sec
Q4LE56
resolver
uniprot_sec
Q6NVJ7
resolver
uniprot_sec
Q86Y95
resolver
amino_acid_sequence
MALQVELVPTGEIIRVVHPHRPCKLALGSDGVRVTMESALTARDRVGVQDFVLLENFTSEAAFIENLRRRFRENLIYTYIGPVLVSVNPYRDLQIYSRQHMERYRGVSFYEVPPHLFAVADTVYRALRTERRDQAVMISGESGAGKTEATKRLLQFYAETCPAPERGGAVRDRLLQSNPVLEAFGNAKTLRNDNSSRFGKYMDVQFDFKGAPVGGHILSYLLEKSRVVHQNHGERNFHIFYQLLEGGEEETLRRLGLERNPQSYLYLVKGQCAKVSSINDKSDWKVVRKALTVIDFTEDEVEDLLSIVASVLHLGNIHFAANEESNAQVTTENQLKYLTRLLSVEGSTLREALTHRKIIAKGEELLSPLNLEQAAYARDALAKAVYSRTFTWLVGKINRSLASKDVESPSWRSTTVLGLLDIYGFEVFQHNSFEQFCINYCNEKLQQLFIELTLKSEQEEYEAEGIAWEPVQYFNNKIICDLVEEKFKGIISILDEECLRPGEATDLTFLEKLEDTVKHHPHFLTHKLADQRTRKSLGRGEFRLLHYAGEVTYSVTGFLDKNNDLLFRNLKETMCSSKNPIMSQCFDRSELSDKKRPETVATQFKMSLLQLVEILQSKEPAYVRCIKPNDAKQPGRFDEVLIRHQVKYLGLLENLRVRRAGFAYRRKYEAFLQRYKSLCPETWPTWAGRPQDGVAVLVRHLGYKPEEYKMGRTKIFIRFPKTLFATEDALEVRRQSLATKIQAAWRGFHWRQKFLRVKRSAICIQSWWRGTLGRRKAAKRKWAAQTIRRLIRGFVLRHAPRCPENAFFLDHVRTSFLLNLRRQLPQNVLDTSWPTPPPALREASELLRELCIKNMVWKYCRSISPEWKQQLQQKAVASEIFKGKKDNYPQSVPRLFISTRLGTDEISPRVLQALGSEPIQYAVPVVKYDRKGYKPRSRQLLLTPNAVVIVEDAKVKQRIDYANLTGISVSSLSDSLFVLHVQRADNKQKGDVVLQSDHVIETLTKTALSANRVNSININQGSITFAGGPGRDGTIDFTPGSELLITKAKNGHLAVVAPRLNSR
uniprot
proteins
function
FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes. {ECO:0000269|PubMed:24636949}.; FUNCTION: [Isoform 3]: Involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation. {ECO:0000250|UniProtKB:Q9WTI7}.
uniprot
proteins
mass_dalton
121682
uniprot
proteins
mutagenesis
MUTAGEN 736; /note="S->A: Abolishes interaction with YWHAB."; /evidence="ECO:0000269|PubMed:24636949"; MUTAGEN 736; /note="S->E: Increases affinity for YWHAB."; /evidence="ECO:0000269|PubMed:24636949
uniprot
proteins
post_translational_modification
PTM: Isoform 2 contains a N-acetylmethionine at position 1.
uniprot
proteins
protein_family
Myosin family
uniprot
proteins
protein_family
TRAFAC class myosin-kinesin ATPase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16133118
uniprot
proteins
pubmed
16603771
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16877530
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22736583
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24636949
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
34380438
uniprot
proteins
pubmed
9119401
uniprot
proteins
sequence_length
1063
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22736583}. Nucleus {ECO:0000269|PubMed:22736583}. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q9WTI7}. Cell projection, stereocilium membrane {ECO:0000250|UniProtKB:Q92002}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:Q9WTI7}. Cell projection, ruffle membrane {ECO:0000269|PubMed:34380438}. Note=Colocalizes with CABP1 and CIB1 at cell margin, membrane ruffles and punctate regions on the cell membrane (By similarity). Colocalizes in adipocytes with GLUT4 at actin-based membranes (By similarity). Colocalizes with GLUT4 at insulin-induced ruffles at the cell membrane (By similarity). Localizes transiently at cell membrane to region known to be enriched in PIP2 (By similarity). Activation of phospholipase C results in its redistribution to the cytoplasm (By similarity). Colocalizes with RNA polymerase II (PubMed:22736583). Translocates to nuclear speckles upon exposure to inhibitors of RNA polymerase II transcription (PubMed:22736583). {ECO:0000250|UniProtKB:Q9WTI7, ECO:0000269|PubMed:22736583}.; SUBCELLULAR LOCATION: [Isoform 3]: Nucleus, nucleoplasm {ECO:0000269|PubMed:16133118}. Nucleus, nucleolus {ECO:0000269|PubMed:16133118, ECO:0000269|PubMed:16877530}. Note=Colocalizes with RNA polymerase II in the nucleus (By similarity). Colocalizes with RNA polymerase I in nucleoli (By similarity). In the nucleolus, is localized predominantly in dense fibrillar component (DFC) and in granular component (GC) (PubMed:16133118, PubMed:16877530). Accumulates strongly in DFC and GC during activation of transcription (PubMed:16133118). Colocalizes with transcription sites (By similarity). Colocalizes in the granular cortex at the periphery of the nucleolus with RPS6 (PubMed:16877530). Colocalizes in nucleoplasm with RPS6 and actin that are in contact with RNP particles (PubMed:16877530). Colocalizes with RPS6 at the nuclear pore level (PubMed:16877530). {ECO:0000250|UniProtKB:Q9WTI7, ECO:0000269|PubMed:16133118, ECO:0000269|PubMed:16877530}.
uniprot
proteins