CHI3L1
entrez
1116
canonical
uniprot
P36222
canonical
ensembl
ENSG00000133048
resolver
ensp
ENSP00000255409
resolver
ensp
ENSP00000544833
resolver
ensp
ENSP00000616629
resolver
ensp
ENSP00000706606
resolver
enst
ENST00000255409
resolver
genesymbol
CHI3L1
resolver
hgnc
HGNC:1932
resolver
uniprot
B2R7B0
resolver
uniprot
P30923
resolver
uniprot
Q8IVA4
resolver
uniprot
Q96HI7
resolver
uniprot_entry
CH3L1_HUMAN
resolver
uniprot_sec
B2R7B0
resolver
uniprot_sec
P30923
resolver
uniprot_sec
Q8IVA4
resolver
uniprot_sec
Q96HI7
resolver
amino_acid_sequence
MGVKASQTGFVVLVLLQCCSAYKLVCYYTSWSQYREGDGSCFPDALDRFLCTHIIYSFANISNDHIDTWEWNDVTLYGMLNTLKNRNPNLKTLLSVGGWNFGSQRFSKIASNTQSRRTFIKSVPPFLRTHGFDGLDLAWLYPGRRDKQHFTTLIKEMKAEFIKEAQPGKKQLLLSAALSAGKVTIDSSYDIAKISQHLDFISIMTYDFHGAWRGTTGHHSPLFRGQEDASPDRFSNTDYAVGYMLRLGAPASKLVMGIPTFGRSFTLASSETGVGAPISGPGIPGRFTKEAGTLAYYEICDFLRGATVHRILGQQVPYATKGNQWVGYDDQESVKSKVQYLKDRQLAGAMVWALDLDDFQGSFCGQDLRFPLTNAIKDALAAT
uniprot
proteins
disease_involvement
DISEASE: Asthma-related traits 7 (ASRT7) [MIM:611960]: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis. {ECO:0000269|PubMed:18403759}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.; DISEASE: Schizophrenia (SCZD) [MIM:181500]: A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. {ECO:0000269|PubMed:17160890, ECO:0000269|PubMed:20051317}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung. {ECO:0000269|PubMed:16472595, ECO:0000269|PubMed:19414556, ECO:0000269|PubMed:20558631, ECO:0000269|PubMed:9492324}.
uniprot
proteins
mass_dalton
42625
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000269|PubMed:12775711}.
uniprot
proteins
protein_family
Glycosyl hydrolase 18 family
uniprot
proteins
pubmed
12775711
uniprot
proteins
pubmed
12851408
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16472595
uniprot
proteins
pubmed
17160890
uniprot
proteins
pubmed
18403759
uniprot
proteins
pubmed
19414556
uniprot
proteins
pubmed
20051317
uniprot
proteins
pubmed
20558631
uniprot
proteins
pubmed
2375755
uniprot
proteins
pubmed
8245017
uniprot
proteins
pubmed
9244440
uniprot
proteins
pubmed
9492324
uniprot
proteins
sequence_length
383
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space {ECO:0000269|PubMed:9492324}. Cytoplasm {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}.
uniprot
proteins