Akna
entrez
100182
canonical
uniprot
Q80VW7
canonical
ensembl
ENSMUSG00000039158
resolver
ensp
ENSMUSP00000041614
resolver
ensp
ENSMUSP00000297675
resolver
ensp
ENSMUSP00000297676
resolver
genesymbol
Akna
resolver
genesymbol_syn
Kiaa1968
resolver
uniprot
Q3TC64
resolver
uniprot
Q3TDM3
resolver
uniprot
Q3U3N4
resolver
uniprot
Q6ZPF9
resolver
uniprot
Q8CFV0
resolver
uniprot
Q8R114
resolver
uniprot_entry
AKNA_MOUSE
resolver
uniprot_sec
Q3TC64
resolver
uniprot_sec
Q3TDM3
resolver
uniprot_sec
Q3U3N4
resolver
uniprot_sec
Q6ZPF9
resolver
uniprot_sec
Q8CFV0
resolver
uniprot_sec
Q8R114
resolver
amino_acid_sequence
MASSGAKAQWVGPSLGQGPRRRRWAWAEEQDTDGRRDQGWGNSQSLPEAPSPELLEDFRRAQEHLPPLEWDPDMQDSEESSGEETEADDASSPEGSTVPLPWLSRSNQQLDMSEEELDEASGRPEVDLAGESCTELECEDQGDSSPPPPGQGPAKGWVTFIKQGSNYRPSEHLEAQPSVEHSRTKSWSSGTVSLRQPSDSLGSTWEGDTEVPQPSILPKALPQSPCHNFPHPGDRNGGDVAPATPTEFRDSLAAPAQNAECSAGTWGEETTSLPSSRPEDQTWKRTKTSPKPLPSRFTGSVSPLSTRLGAIKKVVPQHKQGATLAGHSSSQAPKYGRGRRLNYPLPDFSKVGPRVRFPKDENYRPPKSRGHNRQQGSTRPLIFKSPAEIVRDVLLSSGEASLAKESSLAHTITRVPQEFQTPEQATELVHQLQEDYHKLLTKYAEAENTIDQLRLGAKVHLYSDPPQPSQSFCSGSMPQGSKVLSFSIPQPRVAEWWPDPAQDPQASEATGWPFPRTDLSPSSSPGVATPGRLPQSQGIATDQPSTGQTQALTSQASRLLAKVQSFEELVLAGHLPPQDQIKSLEQLRAAHMALEAEYLQACREELLDPQLDASQGSPRTLNLCRELEAEIYHLGQRLEELQDHMDQTQRETEPCRPDLQDSTPTMSFLPQSAHLSMPSGPVSLPDGQTYQEPATTTTTSPGSSCTLPINKKLSLSIKTEESPRGLPVPLRDRTLQVEQDFHGLLERYLSVKSLPEALRDEDEDDLEEEEEEQDHQGPLEVDSPATAPGKTEAVRVPPGERPTQAEESHRDATQEDEEQMGPMKSPDFRPSMARDTYTPVLDTAEVAQRGTKAMVSHQSSLTSLEESRPSELLPRKALLRAGGPHTEEPWMVSPETDSGFVGSETSIVSPFTQTPEHRLSHVSTSGPSAQHLTASVPGDRTSHPKARGLMVPRRATETGIPRSRTQQHFSSLSSPGRGAQSCHLEETSVAKIAVPRSEFKRQKQISKQLLPSGRTSPDSAPAPTAASTPHGSAESTANLLLNRTERDQAIKDLQAEVSRLRLQLEDSLHRPHPDGPACVASAFNHSTQTQEKLGSSPSWGPHYGSKSTERLSREPNGVEPAEPMGRRRARSSSVPRDVPRLYLSSESESPAPRLSSEKSRTFEEHPEAAQWGTRPQSSSKRRERVSFRGQYTGQEYHILSPKAILKDSGTPSCPHCHPIRTQDTGSAVSRDTTRGSSAADTLRCALCGEVKSSAEADGSSSGPSEKNTPKKPSTPILKRKNRQTGSPVRMAPGLWYLAAAPPAPAPPALAYISSAPIMPYLPPTVYYAAPAPTSAQTASPQPARGPRRTRHSVQLGLNDLEELQAALREAAQAAENVRSTTRQLSRSLSADLRHARSLRGSCLF
uniprot
proteins
function
FUNCTION: Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization (PubMed:30787442). Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis (PubMed:30787442). Also regulates the epithelial-to-mesenchymal transition in other epithelial cells (PubMed:30787442). Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot (PubMed:30787442). In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development (By similarity). Binds to A/T-rich promoters (By similarity). It is unclear how it can both act as a microtubule organizer and as a transcription factor; additional evidence is required to reconcile these two apparently contradictory functions (Probable). {ECO:0000250|UniProtKB:Q7Z591, ECO:0000269|PubMed:30787442, ECO:0000305}.
uniprot
proteins
mass_dalton
153123
uniprot
proteins
post_translational_modification
PTM: Phosphorylated; phosphorylation regulates dissociation from and reassembly at the centrosome. {ECO:0000269|PubMed:30787442}.
uniprot
proteins
protein_family
AKNA family
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21606955
uniprot
proteins
pubmed
30787442
uniprot
proteins
sequence_length
1404
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:30787442}. Nucleus {ECO:0000250|UniProtKB:Q7Z591}. Note=Localizes to the distal part of the subdistal appendages of the mother centriole in interphase (PubMed:30787442). Also found at the proximal ends of centrioles and along microtubules (PubMed:30787442). The centrosomal localization is dependent on centrioles (PubMed:30787442). Dissociates from centrosomes during M-phase without proteolytic degradation and reassembles at the centrosomes during late telophase and early G1 phase (PubMed:30787442). Dissociation and reassembly is regulated by phosphorylation (PubMed:30787442). {ECO:0000269|PubMed:30787442}.
uniprot
proteins