GPR132
entrez
29933
canonical
uniprot
Q9UNW8
canonical
ensembl
ENSG00000183484
resolver
ensp
ENSP00000328818
resolver
ensp
ENSP00000376364
resolver
ensp
ENSP00000438094
resolver
genesymbol
GPR132
resolver
genesymbol_syn
G2A
resolver
hgnc
HGNC:17482
resolver
uniprot
A8K7X7
resolver
uniprot
B4E144
resolver
uniprot
Q9BSU2
resolver
uniprot_entry
GP132_HUMAN
resolver
uniprot_sec
A8K7X7
resolver
uniprot_sec
B4E144
resolver
uniprot_sec
Q9BSU2
resolver
amino_acid_sequence
MCPMLLKNGYNGNATPVTTTAPWASLGLSAKTCNNVSFEESRIVLVVVYSAVCTLGVPANCLTAWLALLQVLQGNVLAVYLLCLALCELLYTGTLPLWVIYIRNQHRWTLGLLACKVTAYIFFCNIYVSILFLCCISCDRFVAVVYALESRGRRRRRTAILISACIFILVGIVHYPVFQTEDKETCFDMLQMDSRIAGYYYARFTVGFAIPLSIIAFTNHRIFRSIKQSMGLSAAQKAKVKHSAIAVVVIFLVCFAPYHLVLLVKAAAFSYYRGDRNAMCGLEERLYTASVVFLCLSTVNGVADPIIYVLATDHSRQEVSRIHKGWKEWSMKTDVTRLTHSRDTEELQSPVALADHYTFSRPVHPPGSPCPAKRLIEESC
uniprot
proteins
function
FUNCTION: May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensing activity. {ECO:0000269|PubMed:12586833, ECO:0000269|PubMed:19855098, ECO:0000269|PubMed:9770487}.
uniprot
proteins
mass_dalton
42499
uniprot
proteins
mutagenesis
MUTAGEN 7; /note="K->A: No change in basal activity."; /evidence="ECO:0000269|PubMed:19855098"; MUTAGEN 31; /note="K->A: Decreased IP1 accumulation at any pH."; /evidence="ECO:0000269|PubMed:19855098"; MUTAGEN 42; /note="R->A: Decreased basal activity at alkaline pH and loss of proton-sensing activity at low pH."; /evidence="ECO:0000269|PubMed:19855098
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11474113
uniprot
proteins
pubmed
12482833
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
12586833
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15653487
uniprot
proteins
pubmed
19855098
uniprot
proteins
pubmed
9770487
uniprot
proteins
sequence_length
380
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Internalized and accumulated in endosomal compartments. LPC triggers the relocalization from the endosomal compartment to the cell surface (By similarity). {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 46..68; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 80..102; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 117..138; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 159..178; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 198..220; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 247..269; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 289..311; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins