Rpl5
entrez
100503670
canonical
uniprot
P47962
canonical
ensembl
ENSMUSG00000058558
resolver
ensp
ENSMUSP00000080854
resolver
enst
ENSMUST00000082223
resolver
genesymbol
Rpl5
resolver
uniprot
Q3TKR5
resolver
uniprot
Q58EU6
resolver
uniprot
Q9CR19
resolver
uniprot_entry
Q3TKR5_MOUSE
resolver
uniprot_entry
Q58EU6_MOUSE
resolver
uniprot_entry
RL5_MOUSE
resolver
uniprot_sec
Q9CR19
resolver
amino_acid_sequence
MGFVKVVKNKAYFKRYQVRFRRRREGKTDYYARKRLVIQDKNKYNTPKYRMIVRVTNRDIICQIAYARIEGDMIVCAAYAHELPKYGVKVGLTNYAAAYCTGLLLARRLLNRFGMDKIYEGQVEVNGGEYNVESIDGQPGAFTCYLDAGLARTTTGNKVFGALKGAVDGGLSIPHSTKRFPGYDSESKEFNAEVHRKHIMGQNVADYMRYLMEEDEDAYKKQFSQYIKNNVTPDMMEEMYKKAHAAIRENPVYEKKPKREVKKKRWNRPKMSLAQKKDRVAQKKASFLRAQERAAES
uniprot
proteins
function
FUNCTION: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:36517592). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (By similarity). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (By similarity). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (By similarity). As part of the 5S RNP/5S ribonucleoprotein particle it is an essential component of the LSU, required for its formation and the maturation of rRNAs (By similarity). It also couples ribosome biogenesis to p53/TP53 activation (By similarity). As part of the 5S RNP it accumulates in the nucleoplasm and inhibits MDM2, when ribosome biogenesis is perturbed, mediating the stabilization and the activation of TP53 (By similarity). {ECO:0000250|UniProtKB:P46777, ECO:0000269|PubMed:36517592}.
uniprot
proteins
mass_dalton
34401
uniprot
proteins
protein_family
Universal ribosomal protein uL18 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
36517592
uniprot
proteins
pubmed
7937132
uniprot
proteins
sequence_length
297
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:36517592}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P46777}. Note=Although RP5 is functional within the cytoplasm, the assembly of ribosomal subunits occurs in the nucleus. RPL5 nuclear import is mediated by IPO5/RanBP5, IPO7/RanBP7, KPNB1/importin-beta or TPNO1/Trn. {ECO:0000250|UniProtKB:P46777}.
uniprot
proteins