Kcnj13
entrez
100040591
canonical
uniprot
P86046
canonical
ensembl
ENSMUSG00000079436
resolver
ensp
ENSMUSP00000108838
resolver
enst
ENSMUST00000113212
resolver
genesymbol
Kcnj13
resolver
uniprot_entry
KCJ13_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by Ba(2+) and Cs(+), although sensitivity to those inhibitors is much lower than in other Kir channels. {ECO:0000250|UniProtKB:O60928}.
uniprot
proteins
amino_acid_sequence
MDSSNCKVNAPLLSQRHRRMVTKDGHSTLQMDGAQRGLVYLRDAWGILMDMRWRWMMLVFSASFVVHWLVFAVLWYAVAEMNGDLEIDHDVPPENHTICVKHITSFTAAFSFSLETQLTIGYGTMFPSGDCPSAIALLAIQMLLGLMLEAFITGAFVAKIARPKNRAFSIRFTDLAVVAHKDGKPNLIFQVANTRPSPLTNVRVSAVLYQERENGELYQTSVDFHLDGISSEECPFFIFPLTYYHTISPSSPLATLLQHETPPHFELVVFLSAMQEGTGEICQRRTSYLPSEIMLHHRFAALMTRGSKGEYQVKMENFDKTVPEHPTPVVSKSPHRTDLDIHINGQSIDNFQIAETGLTE
uniprot
proteins
function
FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium. {ECO:0000250|UniProtKB:O60928}.
uniprot
proteins
mass_dalton
40565
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-287 by PKA increases ionic currents. {ECO:0000250|UniProtKB:O60928}.
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ13 subfamily
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
30228185
uniprot
proteins
pubmed
31056263
uniprot
proteins
pubmed
39951488
uniprot
proteins
sequence_length
360
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:31056263}. Note=Localized at the retinal pigmented epithelium (RPE) apical microvilli. {ECO:0000269|PubMed:30228185}.
uniprot
proteins
transmembrane_region
TRANSMEM 51..77; /note="Helical; Name=M1"; /evidence="ECO:0000250|UniProtKB:P49655"; TRANSMEM 132..157; /note="Helical; Name=M2"; /evidence="ECO:0000250|UniProtKB:P49655
uniprot
proteins