Efna5
entrez
116683
canonical
uniprot
P97605
canonical
ensembl
ENSRNOG00000034177
resolver
ensp
ENSRNOP00000092647
resolver
ensp
ENSRNOP00000096410
resolver
enst
ENSRNOT00000096180
resolver
enst
ENSRNOT00000116684
resolver
genesymbol
Efna5
resolver
genesymbol_syn
Eplg7
resolver
genesymbol_syn
Lerk7
resolver
uniprot
A0A8I6AFY3
resolver
uniprot
A0A8I6GLK9
resolver
uniprot_entry
A0A8I6AFY3_RAT
resolver
uniprot_entry
A0A8I6GLK9_RAT
resolver
uniprot_entry
EFNA5_RAT
resolver
amino_acid_sequence
MLHVEMLTLLFLVLWMCVFSQDPGSKVVADRYAVYWNSSNPRFQRGDYHIDVCINDYLDVFCPHYEDSVPEDKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQLFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVRPTNSCMKTIGVRDRVFDVNDKVENSLEPADDTVHESAEPSRGENAAQTPRIPSRLLAILLFLLAMLLTL
uniprot
proteins
function
FUNCTION: Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase. Activates the EPHA3 receptor to regulate cell-cell adhesion and cytoskeletal organization. With the receptor EPHA2 may regulate lens fiber cells shape and interactions and be important for lens transparency maintenance. May function actively to stimulate axon fasciculation. The interaction of EFNA5 with EPHA5 also mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion. Cognate/functional ligand for EPHA7, their interaction regulates brain development modulating cell-cell adhesion and repulsion (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
26358
uniprot
proteins
protein_family
Ephrin family
uniprot
proteins
pubmed
7748564
uniprot
proteins
sequence_length
228
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. Membrane, caveola {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}. Note=Compartmentalized in discrete caveolae-like membrane microdomains. {ECO:0000250}.
uniprot
proteins