Gpr25
entrez
383563
canonical
uniprot
P0C5I1
canonical
ensembl
ENSMUSG00000052759
resolver
ensp
ENSMUSP00000083583
resolver
enst
ENSMUST00000086395
resolver
genesymbol
Gpr25
resolver
genesymbol_syn
Gm1300
resolver
uniprot_entry
GPR25_MOUSE
resolver
amino_acid_sequence
MQSTEPWSPSWGTLSWDYSGSGSLDQVELCPAWNLPYGHAIIPALYLAAFAVGLPGNAFVVWLLSRQRGPRRLVDTFVLHLAAADLGFVLTLPLWAAAEARGGLWPFGDGLCKVSSFALAVTRCAGALLLAGMSVDRYLAVGRPLSARPLRSARCVRAVCGAAWAAAFLAGLPALLYRGLQPSLDGVGSQCAEEPWEALQGVGLLLLLLTFALPLAVTLICYWRVSRRLPRVGRARSNSLRIIFTVESVFVGCWLPFGVLRSLFHLARLQALPLPCSLLLALRWGLTVTTCLAFVNSSANPVIYLLLDRSFRARARFGLCARAGRQVRRISSASSLSRDDSSVFRGRSPKVNSASATW
uniprot
proteins
function
FUNCTION: Receptor for the C-X-C chemokine CXCL17, which plays a key role in lymphocyte homing. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as RhoA pathway. Activation by CXCL17 on lymphocytes activates the RhoA pathway, which regulates cytoskeletal dynamics and integrins, mediating lymphocyte recruitment into the respiratory, upper gastrointestinal, biliary and genito-urinary tracts. {ECO:0000250|UniProtKB:O00155}.
uniprot
proteins
mass_dalton
38754
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
358
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O00155}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 44..64; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 77..97; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 114..134; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 156..176; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 201..221; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 240..260; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 285..307; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins