Prkacb
entrez
293508
canonical
uniprot
P68182
canonical
ensembl
ENSRNOG00000004978
resolver
ensembl
ENSRNOG00055023932
resolver
ensembl
ENSRNOG00060000873
resolver
ensembl
ENSRNOG00065012881
resolver
ensp
ENSRNOP00000062228
resolver
ensp
ENSRNOP00000086804
resolver
ensp
ENSRNOP00000092040
resolver
ensp
ENSRNOP00000109470
resolver
ensp
ENSRNOP00055033550
resolver
ensp
ENSRNOP00060000416
resolver
ensp
ENSRNOP00065016277
resolver
enst
ENSRNOT00000068739
resolver
enst
ENSRNOT00000117576
resolver
enst
ENSRNOT00000119887
resolver
enst
ENSRNOT00000127717
resolver
enst
ENSRNOT00055041233
resolver
enst
ENSRNOT00060001112
resolver
enst
ENSRNOT00065021101
resolver
genesymbol
Prkacb
resolver
genesymbol_syn
Pkacb
resolver
uniprot
A0A8I6A4F6
resolver
uniprot
A0A8I6AV42
resolver
uniprot
A0ABK0M2V8
resolver
uniprot
P05206
resolver
uniprot_entry
A0A8I6A4F6_RAT
resolver
uniprot_entry
A0A8I6AV42_RAT
resolver
uniprot_entry
A0ABK0M2V8_RAT
resolver
uniprot_entry
KAPCB_RAT
resolver
uniprot_sec
P05206
resolver
activity_regulation
ACTIVITY REGULATION: Activated by cAMP. {ECO:0000250|UniProtKB:P22694}.
uniprot
proteins
amino_acid_sequence
MGNTAIAKKGSEVESVKEFLAKAKEDFLRKWENPPPSNAGLEDFERKKTLGTGSFGRVMLVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVEFPFLVRLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFATTDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEEIRVSITEKCGKEFCEF
uniprot
proteins
ec_number
2.7.11.11
uniprot
proteins
function
FUNCTION: Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates GPKOW which regulates its ability to bind RNA. Acts as a negative regulator of mTORC1 by mediating phosphorylation of RPTOR. {ECO:0000250|UniProtKB:P22694}.
uniprot
proteins
mass_dalton
40708
uniprot
proteins
post_translational_modification
PTM: Asn-3 is deaminated to Asp in more than 25% of the proteins, giving rise to 2 major isoelectric variants, called CB and CA respectively (0.4 pH unit change). Deamidation proceeds via the so-called beta-aspartyl shift mechanism and yields either 'D-Asp-2' (major) or 'D-isoAsp-2' (minor), in addition to L-isomers. Deamidation occurs after the addition of myristate. The Asn-3 form reaches a significantly larger nuclear/cytoplasmic ratio than the 'Asp-2' form. {ECO:0000269|PubMed:9521123}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
cAMP subfamily
uniprot
proteins
pubmed
1610898
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9521123
uniprot
proteins
sequence_length
351
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P22694}. Cell membrane {ECO:0000250|UniProtKB:P22694}. Membrane {ECO:0000250|UniProtKB:P22694}; Lipid-anchor {ECO:0000250|UniProtKB:P22694}. Nucleus {ECO:0000250|UniProtKB:P05131}. Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm. {ECO:0000250|UniProtKB:P05131}.
uniprot
proteins