SPINK5
entrez
11005
canonical
uniprot
Q9NQ38
canonical
ensembl
ENSG00000133710
resolver
ensp
ENSP00000256084
resolver
ensp
ENSP00000352936
resolver
ensp
ENSP00000381472
resolver
genesymbol
SPINK5
resolver
hgnc
HGNC:15464
resolver
uniprot
A8MYE8
resolver
uniprot
B7WPB7
resolver
uniprot
D6REN5
resolver
uniprot
O75770
resolver
uniprot
Q3LX95
resolver
uniprot
Q3LX96
resolver
uniprot
Q3LX97
resolver
uniprot
Q96PP2
resolver
uniprot
Q96PP3
resolver
uniprot_entry
ISK5_HUMAN
resolver
uniprot_sec
A8MYE8
resolver
uniprot_sec
B7WPB7
resolver
uniprot_sec
D6REN5
resolver
uniprot_sec
O75770
resolver
uniprot_sec
Q3LX95
resolver
uniprot_sec
Q3LX96
resolver
uniprot_sec
Q3LX97
resolver
uniprot_sec
Q96PP2
resolver
uniprot_sec
Q96PP3
resolver
amino_acid_sequence
MKIATVSVLLPLALCLIQDAASKNEDQEMCHEFQAFMKNGKLFCPQDKKFFQSLDGIMFINKCATCKMILEKEAKSQKRARHLARAPKATAPTELNCDDFKKGERDGDFICPDYYEAVCGTDGKTYDNRCALCAENAKTGSQIGVKSEGECKSSNPEQDVCSAFRPFVRDGRLGCTRENDPVLGPDGKTHGNKCAMCAELFLKEAENAKREGETRIRRNAEKDFCKEYEKQVRNGRLFCTRESDPVRGPDGRMHGNKCALCAEIFKQRFSEENSKTDQNLGKAEEKTKVKREIVKLCSQYQNQAKNGILFCTRENDPIRGPDGKMHGNLCSMCQAYFQAENEEKKKAEARARNKRESGKATSYAELCSEYRKLVRNGKLACTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGKSRNKRQSKSTASFEELCSEYRKSRKNGRLFCTRENDPIQGPDGKMHGNTCSMCEAFFQQEERARAKAKREAAKEICSEFRDQVRNGTLICTREHNPVRGPDGKMHGNKCAMCASVFKLEEEEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIHGNTCSMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKTHGNKCAMCKAVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLSCTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQMKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGERSNDKEDLCREFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREANERKKKDEEKSSSKPSNNAKDECSEFRNYIRNNELICPRENDPVHGADGKFYTNKCYMCRAVFLTEALERAKLQEKPSHVRASQEEDSPDSFSSLDSEMCKDYRVLPRIGYLCPKDLKPVCGDDGQTYNNPCMLCHENLIRQTNTHIRSTGKCEESSTPGTTAASMPPSDE
uniprot
proteins
disease_involvement
DISEASE: Netherton syndrome (NETH) [MIM:256500]: An autosomal recessive congenital ichthyosis associated with hair shaft abnormalities and anomalies of the immune system. Typical features are ichthyosis linearis circumflexa, ichthyosiform erythroderma, trichorrhexis invaginata (bamboo hair), atopic dermatitis, and hayfever. High postnatal mortality is due to failure to thrive, infections and hypernatremic dehydration. {ECO:0000269|PubMed:10835624}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Serine protease inhibitor, probably important for the anti-inflammatory and/or antimicrobial protection of mucous epithelia. Contribute to the integrity and protective barrier function of the skin by regulating the activity of defense-activating and desquamation-involved proteases. Inhibits KLK5, its major target, in a pH-dependent manner. Inhibits KLK7, KLK14 CASP14, and trypsin. {ECO:0000269|PubMed:10419450, ECO:0000269|PubMed:17596512, ECO:0000269|PubMed:20533828}.
uniprot
proteins
mass_dalton
120714
uniprot
proteins
post_translational_modification
PTM: Proteolytically processed by furin in individual domains (D1, D5, D6, D8 through D11, and D9 through D15) exhibiting various inhibitory potentials for multiple proteases. {ECO:0000269|PubMed:17596512}.
uniprot
proteins
pubmed
10419450
uniprot
proteins
pubmed
10835624
uniprot
proteins
pubmed
11511292
uniprot
proteins
pubmed
11544479
uniprot
proteins
pubmed
11594460
uniprot
proteins
pubmed
12684009
uniprot
proteins
pubmed
15366933
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
16374478
uniprot
proteins
pubmed
17596512
uniprot
proteins
pubmed
20533828
uniprot
proteins
sequence_length
1064
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins