Tm4sf20
entrez
66261
canonical
uniprot
Q9CQY8
canonical
ensembl
ENSMUSG00000026149
resolver
ensp
ENSMUSP00000027331
resolver
enst
ENSMUST00000027331
resolver
genesymbol
Tm4sf20
resolver
uniprot
Q9D3Q0
resolver
uniprot
Q9D3R0
resolver
uniprot_entry
T4S20_MOUSE
resolver
uniprot_sec
Q9D3Q0
resolver
uniprot_sec
Q9D3R0
resolver
amino_acid_sequence
MTCCEGWTSCNGFSLLILILLGVVINCIPLGISLVEADSTSQNPISCYEWWFPGIIGAGLMAIPATTMSLAARKRACCNNKTGMFLSSLFSVITVVGAVYCMLVSLQALLEGPLICNTQANSTVTCEFSLKNLSKFDPESFNLLWFFNGTCVSPTDFKNPTINNMVSNWKIPNSNSEEDRHRIFHFSVFMSLLLVGILELLFGLSQILIGFLGCLCGVSQRRSQIV
uniprot
proteins
function
FUNCTION: Polytopic transmembrane protein. Inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein. {ECO:0000250|UniProtKB:Q53R12}.
uniprot
proteins
mass_dalton
24760
uniprot
proteins
post_translational_modification
PTM: Glycosylated at Asn-132, Asn-148 and Asn-163 in presence of ceramide which inverts the orientation of TM4SF20 in membranes exposing these residues to the endoplasmic reticulum lumen. {ECO:0000250|UniProtKB:Q53R12}.; PTM: Cleaved by signal peptidase at Ser-14 but the peptide does not act as a signal peptide. Cleavage is inhibited by ceramide which inverts the orientation of TM4SF20 in membranes exposing the N-terminus to the cytosol and not to the endoplasmic reticulum lumen. {ECO:0000250|UniProtKB:Q53R12}.
uniprot
proteins
protein_family
L6 tetraspanin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
226
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q53R12}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q53R12}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q53R12}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q53R12}. Note=Ceramide alters the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20. {ECO:0000250|UniProtKB:Q53R12}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..35; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 50..70; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 84..104; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 192..212; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins