Sh3bp1
entrez
300067
canonical
uniprot
D3ZFJ3
canonical
ensembl
ENSRNOG00000009360
resolver
ensp
ENSRNOP00000012480
resolver
enst
ENSRNOT00000012480
resolver
genesymbol
Sh3bp1
resolver
uniprot_entry
3BP1_RAT
resolver
amino_acid_sequence
MMKRQLHRMRQLAHTGSSGRTPETAEFLGEDLLQVEQRLEPAKRAAHNVHKRLQACLQGQSGADMDKRVKKLPLMALSTAMAESFKELDPDSSMGKALEMSCAIQNQLARILAEFEMTLERDVLQPLNRLSEEELPAILKRKKSLQKLVSDWNTLKSRLSQAAKNSGSSQSLGGGSSSHTHMATANKVETLKEDEEELKRKVEQCKDEYLADLYHFSTKEDSYANYFTHLLEIQADYHRKSLTSLDTALAELRDNHSQADSSPLTTAAPFSRVYGVSLRTHLQDLGRDIALPIEACVLLLLSEGMQEEGLFRLAAGASVLKRLKQTMASDPHSLEEFCSDPHAVAGALKSYLRELPEPLMTSDLYDDWMRAASLKEPGARLEALHDVCSRLPQENFNNLRYLMKFLALLAEEQDVNKMTPSNIAIVLGPNLLWPPEKEGDQAQLDAASVSSIQVVGVVEVLIQNADTLFPGDINFSVSGIFSGLAPQEKPNSQQVSEELAPVAVPATAATPTPTPAPTPAPASMTVKERTESELPKPASPKVSRSPTDTTALAEDMTRKTKRPAPARPTMPPPQPSSSRSSPPALSLPAGSVSPGTPQALPRRLVGTSLRAPTVPPPLPPAPPQPARRQSRRLPVSPCPASPVISNMPAQVDQGAATEDRGGPEAVGGHPPTPVLPPQPRPRGLISETD
uniprot
proteins
function
FUNCTION: GTPase activating protein/GAP which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form. By specifically inactivating RAC1 at the leading edge of migrating cells, it regulates the spatiotemporal organization of cell protrusions which is important for proper cell migration (PubMed:21658605). Also negatively regulates CDC42 in the process of actin remodeling and the formation of epithelial cell junctions. Through its GAP activity toward RAC1 and/or CDC42 plays a specific role in phagocytosis of large particles. Specifically recruited by a PI3 kinase/PI3K-dependent mechanism to sites of large particles engagement, inactivates RAC1 and/or CDC42 allowing the reorganization of the underlying actin cytoskeleton required for engulfment. It also plays a role in angiogenesis and the process of repulsive guidance as part of a semaphorin-plexin signaling pathway. Following the binding of PLXND1 to extracellular SEMA3E it dissociates from PLXND1 and inactivates RAC1, inducing the intracellular reorganization of the actin cytoskeleton and the collapse of cells (By similarity). {ECO:0000250|UniProtKB:Q9Y3L3, ECO:0000269|PubMed:21658605}.
uniprot
proteins
mass_dalton
74852
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
21658605
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
689
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection {ECO:0000269|PubMed:21658605}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9Y3L3}. Cell junction, adherens junction {ECO:0000250|UniProtKB:Q9Y3L3}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:Q9Y3L3}. Nucleus {ECO:0000250|UniProtKB:Q9Y3L3}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9Y3L3}. Note=Localizes at the leading edge of migrating cells (PubMed:21658605). Accumulation at forming phagocytic cups is PI3 kinase/bPI3K-dependent and is specific for sites of large particles engagement and their phosphatidylinositol 3,4,5-triphosphate membrane content (By similarity). {ECO:0000250|UniProtKB:Q9Y3L3, ECO:0000269|PubMed:21658605}.
uniprot
proteins