LTC4S
entrez
4056
canonical
uniprot
Q16873
canonical
ensembl
ENSG00000213316
resolver
ensembl
ENSG00000283887
resolver
ensp
ENSP00000292596
resolver
ensp
ENSP00000492334
resolver
enst
ENST00000292596
resolver
enst
ENST00000639087
resolver
genesymbol
LTC4S
resolver
hgnc
HGNC:6719
resolver
uniprot
Q8N6P0
resolver
uniprot
Q9UC73
resolver
uniprot
Q9UD18
resolver
uniprot_entry
LTC4S_HUMAN
resolver
uniprot_sec
Q8N6P0
resolver
uniprot_sec
Q9UC73
resolver
uniprot_sec
Q9UD18
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by MK886. {ECO:0000269|PubMed:27791009}.
uniprot
proteins
amino_acid_sequence
MKDEVALLAAVTLLGVLLQAYFSLQVISARRAFRVSPPLTTGPPEFERVYRAQVNCSEYFPLFLATLWVAGIFFHEGAAALCGLVYLFARLRYFQGYARSAQLRLAPLYASARALWLLVALAALGLLAHFLPAALRAALLGRLRTLLPWA
uniprot
proteins
disease_involvement
DISEASE: Note=LTC4 synthase deficiency is associated with a neurometabolic developmental disorder characterized by muscular hypotonia, psychomotor retardation, failure to thrive, and microcephaly. {ECO:0000269|PubMed:10896305, ECO:0000269|PubMed:9820300}.
uniprot
proteins
ec_number
2.5.1.-
uniprot
proteins
ec_number
4.4.1.20
uniprot
proteins
function
FUNCTION: Catalyzes the conjugation of leukotriene A4 with reduced glutathione (GSH) to form leukotriene C4 with high specificity (PubMed:23409838, PubMed:27365393, PubMed:27791009, PubMed:7937884, PubMed:9153254). Can also catalyze the transfer of a glutathionyl group from glutathione (GSH) to 13(S),14(S)-epoxy-docosahexaenoic acid to form maresin conjugate in tissue regeneration 1 (MCTR1), a bioactive lipid mediator that possess potent anti-inflammatory and proresolving actions (PubMed:27791009). {ECO:0000269|PubMed:23409838, ECO:0000269|PubMed:27365393, ECO:0000269|PubMed:27791009, ECO:0000269|PubMed:7937884, ECO:0000269|PubMed:9153254}.
uniprot
proteins
mass_dalton
16567
uniprot
proteins
mutagenesis
MUTAGEN 36; /note="S->E: Reduced leukotriene-C4 synthase activity by nearly 80%."; /evidence="ECO:0000269|PubMed:27365393"; MUTAGEN 40; /note="T->A: Leukotriene-C4 synthaseactivity is reduced by 30%."; /evidence="ECO:0000269|PubMed:27365393"; MUTAGEN 51; /note="R->T,I: Loss of leukotriene-C4 synthase activity."; /evidence="ECO:0000269|PubMed:9153254"; MUTAGEN 55; /note="N->A: Does not affect leukotriene-C4 synthase activity but substantially increased KM for GSH."; /evidence="ECO:0000269|PubMed:9153254"; MUTAGEN 59; /note="Y->F: Does not affect leukotriene-C4 synthase activity but substantially increased KM for GSH."; /evidence="ECO:0000269|PubMed:9153254"; MUTAGEN 93; /note="Y->F: Reduces Leukotriene-C4 synthase activity and increases the optimum for pH-dependent activity."; /evidence="ECO:0000269|PubMed:9153254"; MUTAGEN 97; /note="Y->F: Does not affect leukotriene-C4 synthase activity but substantially increased KM for GSH."; /evidence="ECO:0000269|PubMed:9153254
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; leukotriene C4 biosynthesis. {ECO:0000305}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-36 by RPS6KB1 inhibits the leukotriene-C4 synthase activity. {ECO:0000269|PubMed:27365393}.
uniprot
proteins
protein_family
MAPEG family
uniprot
proteins
pubmed
10896305
uniprot
proteins
pubmed
12023288
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17632546
uniprot
proteins
pubmed
17632548
uniprot
proteins
pubmed
19233132
uniprot
proteins
pubmed
23409838
uniprot
proteins
pubmed
27365393
uniprot
proteins
pubmed
27791009
uniprot
proteins
pubmed
7599836
uniprot
proteins
pubmed
7766706
uniprot
proteins
pubmed
7937884
uniprot
proteins
pubmed
8052639
uniprot
proteins
pubmed
8446623
uniprot
proteins
pubmed
8626689
uniprot
proteins
pubmed
8898379
uniprot
proteins
pubmed
9153254
uniprot
proteins
pubmed
9820300
uniprot
proteins
sequence_length
150
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus outer membrane {ECO:0000269|PubMed:12023288}; Multi-pass membrane protein. Endoplasmic reticulum membrane {ECO:0000269|PubMed:12023288, ECO:0000269|PubMed:19233132}; Multi-pass membrane protein. Nucleus membrane {ECO:0000269|PubMed:19233132}; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 7..27; /note="Helical"; /evidence="ECO:0000305|PubMed:12023288, ECO:0000305|PubMed:17632546, ECO:0000305|PubMed:17632548"; TRANSMEM 49..69; /note="Helical"; /evidence="ECO:0000305|PubMed:12023288, ECO:0000305|PubMed:17632546, ECO:0000305|PubMed:17632548"; TRANSMEM 74..94; /note="Helical"; /evidence="ECO:0000305|PubMed:12023288, ECO:0000305|PubMed:17632546, ECO:0000305|PubMed:17632548"; TRANSMEM 105..124; /note="Helical"; /evidence="ECO:0000305|PubMed:12023288, ECO:0000305|PubMed:17632546, ECO:0000305|PubMed:17632548
uniprot
proteins