A0A5B9
uniprot
A0A5B9
canonical
amino_acid_sequence
DLKNVFPPKVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADCGFTSESYQQGVLSATILYEILLGKATLYAVLVSALVLMAMVKRKDSRG
uniprot
proteins
function
FUNCTION: Constant region of T cell receptor (TR) beta chain (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585). {ECO:0000303|PubMed:15040585, ECO:0000303|PubMed:23524462, ECO:0000303|PubMed:24600447, ECO:0000303|PubMed:25493333}.
uniprot
proteins
mass_dalton
19968
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15040585
uniprot
proteins
pubmed
16505140
uniprot
proteins
pubmed
20452950
uniprot
proteins
pubmed
20483993
uniprot
proteins
pubmed
20921281
uniprot
proteins
pubmed
21297580
uniprot
proteins
pubmed
21552205
uniprot
proteins
pubmed
22069376
uniprot
proteins
pubmed
22195564
uniprot
proteins
pubmed
22431638
uniprot
proteins
pubmed
23524462
uniprot
proteins
pubmed
24600447
uniprot
proteins
pubmed
24995984
uniprot
proteins
pubmed
25015819
uniprot
proteins
pubmed
25298532
uniprot
proteins
pubmed
25493333
uniprot
proteins
pubmed
26018083
uniprot
proteins
pubmed
26078271
uniprot
proteins
pubmed
26147596
uniprot
proteins
pubmed
26758806
uniprot
proteins
pubmed
26875526
uniprot
proteins
pubmed
26917722
uniprot
proteins
pubmed
27036003
uniprot
proteins
pubmed
27180909
uniprot
proteins
pubmed
27183386
uniprot
proteins
pubmed
27183389
uniprot
proteins
pubmed
27568928
uniprot
proteins
pubmed
3860845
uniprot
proteins
pubmed
8650574
uniprot
proteins
pubmed
8906788
uniprot
proteins
pubmed
9586631
uniprot
proteins
sequence_length
178
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000303|PubMed:20452950}.
uniprot
proteins
transmembrane_region
TRANSMEM 145..167; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins