Plk2
entrez
20620
canonical
uniprot
P53351
canonical
ensembl
ENSMUSG00000021701
resolver
ensp
ENSMUSP00000022212
resolver
enst
ENSMUST00000022212
resolver
genesymbol
Plk2
resolver
genesymbol_syn
Snk
resolver
uniprot
Q3TV29
resolver
uniprot
Q548A9
resolver
uniprot_entry
PLK2_MOUSE
resolver
uniprot_entry
Q3TV29_MOUSE
resolver
uniprot_entry
Q548A9_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation of Thr-236. Once activated, activity is stimulated by binding target proteins (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MELLRTITYQPAAGTKMCEQALGKACGGDSKKKRPQQPSEDGQPQAQVTPAAPHHHHHHSHSGPEISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLTNNKVYAAKIIPHSRVAKPHQREKIDKEIELHRLLHHKHVVQFYHYFEDKENIYILLEYCSRRSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMELKVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPPFETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFTPDRLSSSCCHTVPDFHLSSPAKNFFKKAAAALFGGKKDKARYNDTHNKVSKEDEDIYKLRHDLKKVSITQQPSKHRADEEPQPPPTTVARSGTSAVENKQQIGDAIRMIVRGTLGSCSSSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQLSTSFQWVTKWVDYSNKYGFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKYFSHYMEENLMDGGDLPSVTDIRRPRLYLLQWLKSDKALMMLFNDGTFQVNFYHDHTKIIICNQSEEYLLTYINEDRISTTFRLTTLLMSGCSLELKNRMEYALNMLLQRCN
uniprot
proteins
ec_number
2.7.11.21
uniprot
proteins
function
FUNCTION: Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins that are already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CPAP, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression. Required for procentriole formation and centriole duplication by phosphorylating CPAP and NPM1, respectively. Its induction by p53/TP53 suggests that it may participate in the mitotic checkpoint following stress. {ECO:0000269|PubMed:12651910, ECO:0000269|PubMed:12897130, ECO:0000269|PubMed:19004816, ECO:0000269|PubMed:21382555}.
uniprot
proteins
mass_dalton
77812
uniprot
proteins
mutagenesis
MUTAGEN 108; /note="K->M: In DN mutant; Loss of kinase activity; leading to disrupted Ras and Rap protein signaling, altered spine morphology and aberrant memory formation in mice."; /evidence="ECO:0000269|PubMed:12651910, ECO:0000269|PubMed:21382555"; MUTAGEN 236; /note="T->D,V: Does not significantly affect kinase activity."; /evidence="ECO:0000269|PubMed:12651910, ECO:0000269|PubMed:12897130"; MUTAGEN 236; /note="T->E: Mimicks phosphorylation state, leading to increased activity."; /evidence="ECO:0000269|PubMed:12651910, ECO:0000269|PubMed:12897130
uniprot
proteins
post_translational_modification
PTM: Catalytic activity is enhanced by phosphorylation of Thr-236. {ECO:0000269|PubMed:12651910}.
uniprot
proteins
protein_family
CDC5/Polo subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Ser/Thr protein kinase family
uniprot
proteins
pubmed
12651910
uniprot
proteins
pubmed
12897130
uniprot
proteins
pubmed
12972611
uniprot
proteins
pubmed
1508211
uniprot
proteins
pubmed
19004816
uniprot
proteins
pubmed
21382555
uniprot
proteins
sequence_length
682
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Note=Localizes to centrosomes during early G1 phase where it only associates to the mother centriole and then distributes equally to both mother and daughter centrioles at the onset of S phase. {ECO:0000250}.
uniprot
proteins