Gabrb3
entrez
14402
canonical
uniprot
P63080
canonical
ensembl
ENSMUSG00000033676
resolver
ensp
ENSMUSP00000038051
resolver
ensp
ENSMUSP00000143353
resolver
enst
ENSMUST00000039697
resolver
enst
ENSMUST00000196198
resolver
genesymbol
Gabrb3
resolver
genesymbol_syn
Gabrb-3
resolver
uniprot
A0A0G2JFY4
resolver
uniprot
P15433
resolver
uniprot
Q3UHR3
resolver
uniprot
Q8C446
resolver
uniprot_entry
A0A0G2JFY4_MOUSE
resolver
uniprot_entry
GBRB3_MOUSE
resolver
uniprot_entry
Q8C446_MOUSE
resolver
uniprot_sec
P15433
resolver
uniprot_sec
Q3UHR3
resolver
activity_regulation
ACTIVITY REGULATION: Potentiated by histamine. {ECO:0000250|UniProtKB:P28472}.
uniprot
proteins
amino_acid_sequence
MWGFAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSEINRVDAHGNILLAPMDVHNEMNEVAGSVGDTRNSAISFDNSGIQYRKQSMPKEGHGRYMGDRSIPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN
uniprot
proteins
function
FUNCTION: Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:9108119). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). GABAARs containing beta-3/GABRB3 subunit are found at both synaptic and extrasynaptic sites (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (PubMed:9108119). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (PubMed:9108119). GABAARs containing alpha-1 and beta-3 subunits exhibit synaptogenic activity; the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation (PubMed:27129275). Extrasynaptic beta-3 receptors contribute to the tonic GABAergic inhibition (By similarity). GABAARs containing alpha-1, beta-3 and epsilon subunits may permit spontaneous chloride channel activity while preserving the structural information required for GABA-gated openings (By similarity). Beta-containing GABAARs can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (By similarity). Plays an important role in somatosensation and in the production of antinociception (PubMed:10670447). {ECO:0000250|UniProtKB:P28472, ECO:0000250|UniProtKB:P63079, ECO:0000269|PubMed:10670447, ECO:0000269|PubMed:27129275, ECO:0000269|PubMed:9108119}.
uniprot
proteins
mass_dalton
54166
uniprot
proteins
protein_family
GABRB3 sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
10670447
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
27129275
uniprot
proteins
pubmed
28978485
uniprot
proteins
pubmed
7893750
uniprot
proteins
pubmed
9108119
uniprot
proteins
sequence_length
473
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:P28472}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:28978485}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P28472}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P63079}.
uniprot
proteins
transmembrane_region
TRANSMEM 247..267; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P28472"; TRANSMEM 272..292; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P28472"; TRANSMEM 305..328; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P28472"; TRANSMEM 448..470; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P28472
uniprot
proteins