Cds1
entrez
81925
canonical
uniprot
O35052
canonical
ensembl
ENSRNOG00000002142
resolver
ensembl
ENSRNOG00055024648
resolver
ensembl
ENSRNOG00060009751
resolver
ensembl
ENSRNOG00065012493
resolver
ensp
ENSRNOP00000002918
resolver
ensp
ENSRNOP00055034653
resolver
ensp
ENSRNOP00060012856
resolver
ensp
ENSRNOP00065015629
resolver
enst
ENSRNOT00000002918
resolver
enst
ENSRNOT00055042434
resolver
enst
ENSRNOT00060016448
resolver
enst
ENSRNOT00065020331
resolver
genesymbol
Cds1
resolver
genesymbol_syn
Cds
resolver
uniprot
A0JPL6
resolver
uniprot
O88208
resolver
uniprot_entry
CDS1_RAT
resolver
uniprot_sec
A0JPL6
resolver
uniprot_sec
O88208
resolver
activity_regulation
ACTIVITY REGULATION: Activated by GTP. Inhibited by CDP-diacylglycerol and by phosphatidylglycerol 4,5-bisphosphate (PPI2). {ECO:0000269|PubMed:9083091, ECO:0000269|PubMed:9345289}.
uniprot
proteins
amino_acid_sequence
MLELRHRGGCPGPGGAGTPPPREGEAAGGDHETESTSDKETDIDDRYGDLDARGDSDVPEVPPSSDRTPEILKKALSGLSSRWKNWWIRGILTLTMISLFFLIIYMGSFMLMLLVLGIQVKCFQEIITIGYRVYHSYDLPWFRTLSWYFLLCVNYFFYGETVADYFATFVQREEQLQFLIRYHRFISFALYLAGFCMFVLSLVKKHYRLQFYMFAWTHVTLLITVTQSHLVIQNLFEGMIWFLVPISSVICNDITAYLFGFFFGRTPLIKLSPKKTWEGFIGGFFSTVIFGFIAAYVLSKYQYFVCPVEYRSDVNSFVTECEPSELFQLQNYSLPPFLQAVLSRETVSLYPFQIHSIALSTFASLIGPFGGFFASGFKRAFKIKDFANTIPGHGGIMDRFDCQYLMATFVHVYITSFIRGPNPSKVLQQLLVLQPEQQLNIYRTLKIHLTEKGILQPTWKV
uniprot
proteins
ec_number
2.7.7.41
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed:29253589, PubMed:30862571, PubMed:9083091, PubMed:9345289). Exhibits almost no acyl chain preference for PA, showing no discrimination for the sn-1/sn-2 acyl chain composition of PAs (By similarity). Plays an important role in regulatinng the growth of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (By similarity). Positively regulates the differentiation and development of adipocytes (By similarity). {ECO:0000250|UniProtKB:P98191, ECO:0000250|UniProtKB:Q92903, ECO:0000269|PubMed:29253589, ECO:0000269|PubMed:30862571, ECO:0000269|PubMed:9083091, ECO:0000269|PubMed:9345289}.
uniprot
proteins
mass_dalton
52970
uniprot
proteins
pathway_participation
PATHWAY: Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
uniprot
proteins
protein_family
CDS family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
29253589
uniprot
proteins
pubmed
30862571
uniprot
proteins
pubmed
6271231
uniprot
proteins
pubmed
9083091
uniprot
proteins
pubmed
9345289
uniprot
proteins
sequence_length
461
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:29253589, ECO:0000269|PubMed:6271231, ECO:0000269|PubMed:9083091}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 96..116; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 149..169; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 183..203; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 230..250; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 279..299; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 357..377; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins