Q9QXF7
uniprot
Q9QXF7
canonical
amino_acid_sequence
MLATAGSLIATIWAALHLRTLLVAALTFLLLADYFKTRRPKNYPPGPWGLPFVGNIFQLDFGQPHLSIQPFVKKYGNIFSLNLGDITSVVITGLPLIKETFTHIEQNILNRPLSVMQERITNKNGLIFSSGQTWKEQRRFALMTLRNFGLGKKSLEQRMQEEAHYLVEAIREEKGKPFNPHFSINNAVSNIICSVTFGERFEYHDSRFQEMLRLLDEVMYLETTMISQLYNIFPWIMKYIPGSHQTVFRNWEKLKLFVSSMIDDHRKDWNPEEPRDFIDAFLKEMSKYPEKTTSFNEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEVQEKVQAEIDRVIGQKRAASLADRESMPYTNAVIHEVQRMGNIIPLNVPREVAMDTTLNGFHLPKGTMVLTNLTALHRDPKEWATPDVFNPEHFLENGQFKKRESFLPFSMGKRACLGEQLARSELFIFFTSLMQKFTFKPPTNEKLSLKFRNGLTLSPVTHRICAVPRE
uniprot
proteins
ec_number
1.14.14.1
uniprot
proteins
function
FUNCTION: A cytochrome P450 monooxygenase that may play a major role in intestinal retinoid metabolism. Catalyzes the oxidative transformation of all-trans retinal and 9-cis-retinal to the corresponding active forms all-trans and 9-cis retinoic acids (PubMed:9606960). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates arachidonic acid predominantly at the omega-1 position (PubMed:9143331). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH--hemoprotein reductase) (PubMed:9143331, PubMed:9606960). {ECO:0000269|PubMed:9143331, ECO:0000269|PubMed:9606960}.
uniprot
proteins
mass_dalton
57878
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; arachidonate metabolism. {ECO:0000305|PubMed:9143331}.; PATHWAY: Cofactor metabolism; retinol metabolism. {ECO:0000305|PubMed:9606960}.
uniprot
proteins
protein_family
Cytochrome P450 family
uniprot
proteins
pubmed
9143331
uniprot
proteins
pubmed
9606960
uniprot
proteins
sequence_length
501
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:9143331, ECO:0000269|PubMed:9606960}; Multi-pass membrane protein {ECO:0000255}. Microsome membrane {ECO:0000269|PubMed:9143331, ECO:0000269|PubMed:9606960}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 77..97; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins