Asb4
entrez
65255
canonical
uniprot
Q9WV71
canonical
ensembl
ENSMUSG00000042607
resolver
ensp
ENSMUSP00000040331
resolver
ensp
ENSMUSP00000224508
resolver
enst
ENSMUST00000043294
resolver
genesymbol
Asb4
resolver
uniprot
Q3UZE1
resolver
uniprot
Q3V070
resolver
uniprot_entry
ASB4_MOUSE
resolver
uniprot_sec
Q3UZE1
resolver
uniprot_sec
Q3V070
resolver
amino_acid_sequence
MDGITAPISKAGAAKLVKKDFLEALKTNDFGKLKAILIERQIDVDTVFEVEDENMILASYKQGYWLPSYKLKSSWATGLHLSVLLGHVECLMVLLDHNATINCRPNGKTPLHVACEIANLECVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVLRGANVNMKTNNQDEETPLHTAAHFGLSELVAFYVENGAIVDSMNAHMETPLAIATYWALRFKEQEYSREHHLICRTLLDNNAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVLKVTSVRPAAQPEICYQLLLNHGAARIYPPQFHKVIQACHSCPKAIEVVVNAYEHIRWNIKWRRAIPDDDLEKHWDFYHSLFKVCCNTPRTLMHLSRCAIRKALHNRCHKAIPMLSLPLPLKKYLLLEPEGIIY
uniprot
proteins
function
FUNCTION: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes differentiation and maturation of the vascular lineage by an oxygen-dependent mechanism. Regulates IRS4 levels by directing its degradation via ubiquitination and thereby decreases the downstream signal of IRS4 (By similarity). Also acts as a negative regulator of GPS1, a component of the COP9 signalosome (CSN) multiprotein complex, thereby inhibiting the serine phosphorylation of IRS1 (PubMed:17276034). Plays a critical role during early vascular development and proper placentation (PubMed:24586788, PubMed:35536884). Mechanistically, negatively regulates the transcriptional regulator inhibitor of DNA binding 2/ID2 expression through polyubiquitination and proteasome dependent degradation (PubMed:24586788). {ECO:0000250|UniProtKB:Q9Y574, ECO:0000269|PubMed:17276034, ECO:0000269|PubMed:17636018, ECO:0000269|PubMed:24586788, ECO:0000269|PubMed:35536884}.
uniprot
proteins
mass_dalton
48098
uniprot
proteins
mutagenesis
MUTAGEN 238; /note="L->D: Abolishes interaction with HIF1AN."; /evidence="ECO:0000269|PubMed:17636018"; MUTAGEN 239; /note="L->D: Abolishes interaction with HIF1AN."; /evidence="ECO:0000269|PubMed:17636018"; MUTAGEN 244..246; /note="EVN->ATA: Abolishes interaction with HIF1AN. Fails to induce expansion of the hematovascular lineage in embryonic stem cells."; /evidence="ECO:0000269|PubMed:17636018"; MUTAGEN 244; /note="E->A: Impairs interaction with HIF1AN."; /evidence="ECO:0000269|PubMed:17636018"; MUTAGEN 245; /note="V->T: Impairs interaction with HIF1AN."; /evidence="ECO:0000269|PubMed:17636018"; MUTAGEN 246; /note="N->A: Abolishes interaction with HIF1AN."; /evidence="ECO:0000269|PubMed:17636018"; MUTAGEN 256; /note="L->D: Abolishes interaction with HIF1AN."; /evidence="ECO:0000269|PubMed:17636018
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Hydroxylation at Asn-246 by HIF1AN may provide an oxygen-dependent regulation mechanism for the function of ASB4 in promoting vascular differentiation. {ECO:0000269|PubMed:17636018}.
uniprot
proteins
protein_family
Ankyrin SOCS box (ASB) family
uniprot
proteins
pubmed
11111040
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17276034
uniprot
proteins
pubmed
17636018
uniprot
proteins
pubmed
24586788
uniprot
proteins
pubmed
35536884
uniprot
proteins
sequence_length
426
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17276034}.
uniprot
proteins