Arfgap3
entrez
503165
canonical
uniprot
Q4KLN7
canonical
ensembl
ENSRNOG00000046472
resolver
ensembl
ENSRNOG00055031212
resolver
ensembl
ENSRNOG00060021424
resolver
ensembl
ENSRNOG00065033151
resolver
ensp
ENSRNOP00000065256
resolver
ensp
ENSRNOP00055044760
resolver
ensp
ENSRNOP00060030757
resolver
ensp
ENSRNOP00065046959
resolver
enst
ENSRNOT00055054120
resolver
enst
ENSRNOT00060037282
resolver
enst
ENSRNOT00065057054
resolver
genesymbol
Arfgap3
resolver
uniprot_entry
ARFG3_RAT
resolver
activity_regulation
ACTIVITY REGULATION: GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2). {ECO:0000250|UniProtKB:Q9NP61}.
uniprot
proteins
amino_acid_sequence
MGDPSKQDILAIFKRLRSVPTNKVCFDCGAKNPSWASISYGVFLCIDCSGSHRSLGVHLSFIRSTELDSNWSWFQLRCMQVGGNANASSFFHQHGCATKDTNAKYNSRAAQLYREKIKTLATQATRRHGTDLWLDSCAAPPASPPPKEEDFFASHASLEVSGATQASAQPEPASSTPWGLETTPEKHEGGPGQGPSVEGLNTPGKTAPAEVSSIIKKKPNQAKKGLGAKKGSLGAQKLTNTSFTEIEKQAQAVDKRKEQEDLARGTPKEESIVSSLRLAYKDLEIHKKQDERLNLSGQKKAEAERLGMGFGSCRGGISHSVTSDMQTIEQESPTLAKPRRKYQEDPEDSYFSSSSKWSEQSSSRYFDDPMELRSSHFSSWDDSADSYWKKDSSRDPEPATKSTGSSDRPSSRRKPEYEPVGNTDEAQKKFGNVKAISSDMYFGIQSQTDFETRARLERLSTSSSISSADLFDEQRKQTTGNYNLSNVLPNAPDMAQFKQGVRSVAGKLSVFANGVMTSIQDRYGS
uniprot
proteins
function
FUNCTION: GTPase-activating protein (GAP) for ADP ribosylation factor 1 (ARF1), which is essential for COPI vesicle formation and retrograde transport between the Golgi and the endoplasmic reticulum (PubMed:19015319). Hydrolysis of ARF1-bound GTP leads to dissociation of coatomer from Golgi-derived membranes to allow fusion with target membranes (By similarity). Promotes the proper assembly of the COPI coat lattice, rather than just acting as a simple curvature-dependent GAP like ARFGAP1 (By similarity). {ECO:0000250|UniProtKB:Q9NP61, ECO:0000269|PubMed:19015319}.
uniprot
proteins
mass_dalton
57671
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19015319
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
525
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:19015319}; Peripheral membrane protein {ECO:0000269|PubMed:19015319}; Cytoplasmic side {ECO:0000250|UniProtKB:Q8N6H7}. Cytoplasm {ECO:0000250|UniProtKB:Q9NP61}. Note=Also found on peripheral punctate structures likely to be endoplasmic reticulum-Golgi intermediate compartment. {ECO:0000250|UniProtKB:Q9NP61}.
uniprot
proteins