KDM4B
entrez
23030
canonical
uniprot
O94953
canonical
ensembl
ENSG00000127663
resolver
ensp
ENSP00000159111
resolver
ensp
ENSP00000371178
resolver
ensp
ENSP00000440495
resolver
ensp
ENSP00000480642
resolver
ensp
ENSP00000608314
resolver
ensp
ENSP00000629378
resolver
ensp
ENSP00000629379
resolver
ensp
ENSP00000796387
resolver
ensp
ENSP00000796388
resolver
enst
ENST00000159111
resolver
enst
ENST00000536461
resolver
enst
ENST00000611640
resolver
enst
ENST00000938255
resolver
enst
ENST00000959319
resolver
enst
ENST00000959320
resolver
genesymbol
KDM4B
resolver
genesymbol_syn
JHDM3B
resolver
genesymbol_syn
JMJD2B
resolver
genesymbol_syn
KIAA0876
resolver
hgnc
HGNC:29136
resolver
uniprot
A0A0C4DFL8
resolver
uniprot
B9EGN8
resolver
uniprot
D6W631
resolver
uniprot
F5GX28
resolver
uniprot
O75274
resolver
uniprot
Q6P3R5
resolver
uniprot
Q9P1V1
resolver
uniprot
Q9UF40
resolver
uniprot_entry
A0A0C4DFL8_HUMAN
resolver
uniprot_entry
F5GX28_HUMAN
resolver
uniprot_entry
KDM4B_HUMAN
resolver
uniprot_sec
B9EGN8
resolver
uniprot_sec
D6W631
resolver
uniprot_sec
O75274
resolver
uniprot_sec
Q6P3R5
resolver
uniprot_sec
Q9P1V1
resolver
uniprot_sec
Q9UF40
resolver
amino_acid_sequence
MGSEDHGAQNPSCKIMTFRPTMEEFKDFNKYVAYIESQGAHRAGLAKIIPPKEWKPRQTYDDIDDVVIPAPIQQVVTGQSGLFTQYNIQKKAMTVGEYRRLANSEKYCTPRHQDFDDLERKYWKNLTFVSPIYGADISGSLYDDDVAQWNIGSLRTILDMVERECGTIIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHFGEPKSWYAIPPEHGKRLERLAIGFFPGSSQGCDAFLRHKMTLISPIILKKYGIPFSRITQEAGEFMITFPYGYHAGFNHGFNCAESTNFATLRWIDYGKVATQCTCRKDMVKISMDVFVRILQPERYELWKQGKDLTVLDHTRPTALTSPELSSWSASRASLKAKLLRRSHRKRSQPKKPKPEDPKFPGEGTAGAALLEEAGGSVKEEAGPEVDPEEEEEEPQPLPHGREAEGAEEDGRGKLRPTKAKSERKKKSFGLLPPQLPPPPAHFPSEEALWLPSPLEPPVLGPGPAAMEESPLPAPLNVVPPEVPSEELEAKPRPIIPMLYVVPRPGKAAFNQEHVSCQQAFEHFAQKGPTWKEPVSPMELTGPEDGAASSGAGRMETKARAGEGQAPSTFSKLKMEIKKSRRHPLGRPPTRSPLSVVKQEASSDEEASPFSGEEDVSDPDALRPLLSLQWKNRAASFQAERKFNAAAARTEPYCAICTLFYPYCQALQTEKEAPIASLGKGCPATLPSKSRQKTRPLIPEMCFTSGGENTEPLPANSYIGDDGTSPLIACGKCCLQVHASCYGIRPELVNEGWTCSRCAAHAWTAECCLCNLRGGALQMTTDRRWIHVICAIAVPEARFLNVIERHPVDISAIPEQRWKLKCVYCRKRMKKVSGACIQCSYEHCSTSFHVTCAHAAGVLMEPDDWPYVVSITCLKHKSGGHAVQLLRAVSLGQVVITKNRNGLYYRCRVIGAASQTCYEVNFDDGSYSDNLYPESITSRDCVQLGPPSEGELVELRWTDGNLYKAKFISSVTSHIYQVEFEDGSQLTVKRGDIFTLEEELPKRVRSRLSLSTGAPQEPAFSGEEAKAAKRPRVGTPLATEDSGRSQDYVAFVESLLQVQGRPGAPF
uniprot
proteins
disease_involvement
DISEASE: Intellectual developmental disorder, autosomal dominant 65 (MRD65) [MIM:619320]: An autosomal dominant form of intellectual disability, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRD65 is characterized by delayed motor and speech acquisition, variably impaired intellectual development, behavioral abnormalities, and dysmorphic facial features. Additional variable features include feeding difficulties, hypotonia, and seizures. {ECO:0000269|PubMed:33232677}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
1.14.11.66
uniprot
proteins
function
FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate (PubMed:16603238, PubMed:28262558). Plays a critical role in the development of the central nervous system (CNS). {ECO:0000250|UniProtKB:Q91VY5, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:28262558}.
uniprot
proteins
mass_dalton
121897
uniprot
proteins
mutagenesis
MUTAGEN 189..191; /note="HTE->ATA: Abolishes lysine-specific histone demethylase activity."; /evidence="ECO:0000269|PubMed:28262558
uniprot
proteins
protein_family
JHDM3 histone demethylase family
uniprot
proteins
pubmed
10048485
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15927959
uniprot
proteins
pubmed
16603238
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28262558
uniprot
proteins
pubmed
33232677
uniprot
proteins
sequence_length
1096
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537, ECO:0000269|PubMed:15927959}.
uniprot
proteins