Gucy1a1
entrez
60596
canonical
uniprot
Q9ERL9
canonical
ensembl
ENSMUSG00000033910
resolver
ensp
ENSMUSP00000048918
resolver
ensp
ENSMUSP00000142138
resolver
enst
ENSMUST00000048976
resolver
enst
ENSMUST00000193924
resolver
genesymbol
Gucy1a1
resolver
genesymbol_syn
Gucy1a3
resolver
uniprot
Q6GTG0
resolver
uniprot
Q9DBQ3
resolver
uniprot_entry
GCYA1_MOUSE
resolver
uniprot_sec
Q6GTG0
resolver
uniprot_sec
Q9DBQ3
resolver
activity_regulation
ACTIVITY REGULATION: Activated by nitric oxide in the presence of magnesium or manganese ions. NO binding to the haem of the beta subunit GUCY1B1 induces a conformational change that allosterically activates the catalytic domain. {ECO:0000250|UniProtKB:Q02108}.
uniprot
proteins
amino_acid_sequence
MFCRKFKDLKITGECPFSLLAPGQVPKEPTEEVAGGSEGCQATLPICQYFPEKNAEGSLPQRKTSRNRVYLHTLAESICKLIFPECERLNLALQRTLAKHKIEENRKSSEKEDLEKIIAEEAIAAGAPVEALKDSLGEELFKICYEEDEHILGVVGGTLKDFLNSFSTLLKQSSHCQEAERRGRLEDASILCLDKDQDFLNVYYFFPKRTTALLLPGIIKAAARILYESHVEVSLMPPCFRSDCTEFVNQPYLLYSVHVKSTKPSLSPGKPQSSLVIPASLFCKTFPFHFMLDRDLAILQLGNGIRRLVNKRDFQGKPNFEEFFEILTPKINQTFSGIMTMLNMQFVIRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLEDFTGRGLYLSDIPIHNALRDVVLIGEQARAQDGLKKRLGKLKATLEHAHQALEEEKKRTVDLLCSIFPSEVAQQLWQGQIVQAKKFSEVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKVETIGDAYCVAGGLHRESDTHAVQIALMALKMMELSNEVMSPHGEPIKMRIGLHSGSVFAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPRSREELPPNFPSDIPGICHFLDAYHHQGPNSKPWFQDKDVEDGNANFLGKASGID
uniprot
proteins
ec_number
4.6.1.2
uniprot
proteins
function
FUNCTION: Alpha subunit of soluble guanylate cyclase (sGC), a key enzyme in nitric oxide (NO) signaling. sGC functions as a heterodimer consisting of one alpha and one beta subunit. It serves as the primary intracellular receptor for NO, which binds to a heme prosthetic group located on the beta subunit. Upon NO binding, sGC catalyzes the conversion of GTP into cyclic GMP (cGMP), thereby transmitting the NO signal into an ubiquitous intracellular second messenger. {ECO:0000250|UniProtKB:Q02108}.
uniprot
proteins
mass_dalton
77588
uniprot
proteins
protein_family
Adenylyl cyclase class-4/guanylyl cyclase family
uniprot
proteins
pubmed
10984516
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
691
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
uniprot
proteins