MMP23B
entrez
8510
canonical
uniprot
O75900
canonical
ensembl
ENSG00000189409
resolver
ensp
ENSP00000348308
resolver
ensp
ENSP00000561324
resolver
ensp
ENSP00000788754
resolver
genesymbol
MMP23B
resolver
genesymbol_syn
MMP21
resolver
genesymbol_syn
MMP22
resolver
hgnc
HGNC:7171
resolver
uniprot
A2AGN0
resolver
uniprot
A2AGN1
resolver
uniprot
O75894
resolver
uniprot
O75895
resolver
uniprot
Q5QPQ8
resolver
uniprot
Q76P96
resolver
uniprot
Q7LDM6
resolver
uniprot
Q7LDM7
resolver
uniprot
Q9UBR9
resolver
uniprot
Q9UJK8
resolver
uniprot_entry
MMP23_HUMAN
resolver
uniprot_sec
A2AGN0
resolver
uniprot_sec
A2AGN1
resolver
uniprot_sec
O75894
resolver
uniprot_sec
O75895
resolver
uniprot_sec
Q5QPQ8
resolver
uniprot_sec
Q76P96
resolver
uniprot_sec
Q7LDM6
resolver
uniprot_sec
Q7LDM7
resolver
uniprot_sec
Q9UBR9
resolver
uniprot_sec
Q9UJK8
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by TIMP2. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MGRGARVPSEAPGAGVERRWLGAALVALCLLPALVLLARLGAPAVPAWSAAQGDVAALGLSAVPPTRVPGPLAPRRRRYTLTPARLRWDHFNLTYRILSFPRNLLSPRETRRALAAAFRMWSDVSPFSFREVAPEQPSDLRIGFYPINHTDCLVSALHHCFDGPTGELAHAFFPPHGGIHFDDSEYWVLGPTRYSWKKGVWLTDLVHVAAHEIGHALGLMHSQHGRALMHLNATLRGWKALSQDELWGLHRLYGCLDRLFVCASWARRGFCDARRRLMKRLCPSSCDFCYEFPFPTVATTPPPPRTKTRLVPEGRNVTFRCGQKILHKKGKVYWYKDQEPLEFSYPGYLALGEAHLSIIANAVNEGTYTCVVRRQQRVLTTYSWRVRVRG
uniprot
proteins
ec_number
3.4.24.-
uniprot
proteins
function
FUNCTION: Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
43935
uniprot
proteins
mutagenesis
MUTAGEN 78; /note="R->G: Abolishes processing of soluble form."; /evidence="ECO:0000269|PubMed:11328856
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:11328856}.; PTM: Proteolytic cleavage might yield an active form. {ECO:0000250}.
uniprot
proteins
protein_family
Peptidase M10A family
uniprot
proteins
pubmed
11328856
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
9740677
uniprot
proteins
pubmed
9988691
uniprot
proteins
sequence_length
390
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Membrane {ECO:0000269|PubMed:11328856}; Single-pass type II membrane protein {ECO:0000269|PubMed:11328856}. Note=A secreted form produced by proteolytic cleavage may also exist. {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 20..40; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins