KCNE2
entrez
9992
canonical
uniprot
Q9Y6J6
canonical
ensembl
ENSG00000159197
resolver
ensp
ENSP00000290310
resolver
ensp
ENSP00000520524
resolver
enst
ENST00000290310
resolver
enst
ENST00000715813
resolver
genesymbol
KCNE2
resolver
hgnc
HGNC:6242
resolver
uniprot
A5H1P3
resolver
uniprot
D3DSF8
resolver
uniprot
Q52LJ5
resolver
uniprot_entry
KCNE2_HUMAN
resolver
uniprot_sec
A5H1P3
resolver
uniprot_sec
D3DSF8
resolver
uniprot_sec
Q52LJ5
resolver
amino_acid_sequence
MSTLSNFTQTLEDVFRRIFITYMDNWRQNTTAEQEALQAKVDAENFYYVILYLMVMIGMFSFIIVAILVSTVKSKRREHSNDPYHQYIVEDWQEKYKSQILNLEESKATIHENIGAAGFKMSP
uniprot
proteins
disease_involvement
DISEASE: Long QT syndrome 6 (LQT6) [MIM:613693]: A heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. {ECO:0000269|PubMed:10219239, ECO:0000269|PubMed:12185453, ECO:0000269|PubMed:16922724, ECO:0000269|PubMed:19716085}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Atrial fibrillation, familial, 4 (ATFB4) [MIM:611493]: A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. {ECO:0000269|PubMed:15368194}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Ancillary protein that functions as a regulatory subunit of the voltage-gated potassium (Kv) channel complex composed of pore-forming and potassium-conducting alpha subunits and of regulatory beta subunits (PubMed:10219239, PubMed:11034315, PubMed:11101505, PubMed:12185453, PubMed:20533308). KCNE2 beta subunit modulates the gating kinetics and enhances stability of the channel complex (PubMed:10219239, PubMed:11034315, PubMed:11101505, PubMed:12185453, PubMed:20533308). Alters the gating of the delayed rectifier Kv channel containing KCNB1 alpha subunit (PubMed:11101505, PubMed:20533308). Associates with KCNH2/HERG alpha subunit Kv channel to form the rapidly activating component of the delayed rectifying potassium current (IKr) in heart (PubMed:10219239, PubMed:12185453). May associate with KCNQ2 and/or KCNQ3 alpha subunits to modulate the native M-type current (PubMed:11034315). May associate with HCN1 and HCN2 channel subunits to increase potassium current (By similarity). Forms a heterooligomer complex with KCNQ1/KVLQT1 alpha subunits which leads to currents with an apparently instantaneous activation, a rapid deactivation process and a linear current-voltage relationship and decreases the amplitude of the outward current (PubMed:11101505). KCNQ1-KCNE2 channel associates with Na(+)-coupled myo-inositol symporter in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (By similarity). {ECO:0000250|UniProtKB:P63161, ECO:0000250|UniProtKB:Q9D808, ECO:0000269|PubMed:10219239, ECO:0000269|PubMed:11034315, ECO:0000269|PubMed:11101505, ECO:0000269|PubMed:12185453, ECO:0000269|PubMed:20533308}.
uniprot
proteins
mass_dalton
14472
uniprot
proteins
mutagenesis
MUTAGEN 75; /note="K->H: Increases tail current in KCNH2/KCNE2 channel."; /evidence="ECO:0000269|PubMed:11874988
uniprot
proteins
protein_family
Potassium channel KCNE family
uniprot
proteins
pubmed
10219239
uniprot
proteins
pubmed
11034315
uniprot
proteins
pubmed
11101505
uniprot
proteins
pubmed
11874988
uniprot
proteins
pubmed
12185453
uniprot
proteins
pubmed
15368194
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16922724
uniprot
proteins
pubmed
19716085
uniprot
proteins
pubmed
20533308
uniprot
proteins
sequence_length
123
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20533308}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P63161}. Apical cell membrane {ECO:0000250|UniProtKB:Q9D808}; Single-pass membrane protein {ECO:0000255}. Note=Colocalizes with KCNB1 at the plasma membrane. {ECO:0000250|UniProtKB:P63161}.
uniprot
proteins
transmembrane_region
TRANSMEM 49..69; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins