Grin2d
entrez
24412
canonical
uniprot
Q62645
canonical
ensembl
ENSRNOG00000021063
resolver
ensembl
ENSRNOG00055006719
resolver
ensembl
ENSRNOG00060011093
resolver
ensembl
ENSRNOG00065031882
resolver
ensp
ENSRNOP00000028615
resolver
genesymbol
Grin2d
resolver
genesymbol_syn
GluN2D
resolver
uniprot
Q63381
resolver
uniprot
Q63382
resolver
uniprot
Q63729
resolver
uniprot
Q63730
resolver
uniprot_entry
NMDE4_RAT
resolver
uniprot_sec
Q63381
resolver
uniprot_sec
Q63382
resolver
uniprot_sec
Q63729
resolver
uniprot_sec
Q63730
resolver
amino_acid_sequence
MRGAGGPRGPRGPAKMLLLLALACASPFPEEVPGPGAVGGGTGGARPLNVALVFSGPAYAAEAARLGPAVAAAVRSPGLDVRPVALVLNGSDPRSLVLQLCDLLSGLRVHGVVFEDDSRAPAVAPILDFLSAQTSLPIVAVHGGAALVLTPKEKGSTFLQLGSSTEQQLQVIFEVLEEYDWTSFVAVTTRAPGHRAFLSYIEVLTDGSLVGWEHRGALTLDPGAGEAVLGAQLRSVSAQIRLLFCAREEAEPVFRAAEEAGLTGPGYVWFMVGPQLAGGGGSGVPGEPLLLPGGSPLPAGLFAVRSAGWRDDLARRVAAGVAVVARGAQALLRDYGFLPELGHDCRTQNRTHRGESLHRYFMNITWDNRDYSFNEDGFLVNPSLVVISLTRDRTWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDDTQHLTVATLEERPFVIVEPADPISGTCIRDSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLYLVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATGKRPGGSTFTIGKSIWLLWALVFNNSVPVENPRGTTSKIMVLVWAFFAVIFLASYTANLAAFMIQEEYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLKAGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPIDLALLQFLGDDEIEMLERLWLSGICHNDKIEVMSSKLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWRLRHCLGPTHRMDFLLAFSRGMYSCCSAEAAPPPAKPPPPPQPLPSPAYPAARPPPGPAPFVPRERAAADRWRRAKGTGPPGGAAIADGFHRYYGPIEPQGLGLGEARAAPRGAAGRPLSPPTTQPPQKPPPSYFAIVREQEPTEPPAGAFPGFPSPPAPPAAAAAAVGPPLCRLAFEDESPPAPSRWPRSDPESQPLLGGGAGGPSAGAPTAPPPRRAAPPPCAYLDLEPSPSDSEDSESLGGASLGGLEPWWFADFPYPYAERLGPPPGRYWSVDKLGGWRAGSWDYLPPRGGPAWHCRHCASLELLPPPRHLSCSHDGLDGGWWAPPPPPWAAGPPPRRRARCGCPRPHPHRPRASHRAPAAAPHHHRHRRAAGGWDFPPPAPTSRSLEDLSSCPRAAPTRRLTGPSRHARRCPHAAHWGPPLPTASHRRHRGGDLGTRRGSAHFSSLESEV
uniprot
proteins
function
FUNCTION: Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:21522138, PubMed:23625947, PubMed:7512349). Participates in synaptic plasticity for learning and memory formation (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:21522138, PubMed:23625947, PubMed:7512349). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:23625947, PubMed:7512349, PubMed:9463421). {ECO:0000250|UniProtKB:P35438, ECO:0000250|UniProtKB:Q14957, ECO:0000269|PubMed:21522138, ECO:0000269|PubMed:23625947, ECO:0000269|PubMed:7512349, ECO:0000269|PubMed:9463421}.
uniprot
proteins
mass_dalton
143101
uniprot
proteins
protein_family
Glutamate-gated ion channel (TC 1.A.10.1) family
uniprot
proteins
protein_family
NR2D/GRIN2D subfamily
uniprot
proteins
pubmed
21522138
uniprot
proteins
pubmed
23625947
uniprot
proteins
pubmed
7512349
uniprot
proteins
pubmed
7569905
uniprot
proteins
pubmed
8428958
uniprot
proteins
pubmed
9463421
uniprot
proteins
pubmed
9647694
uniprot
proteins
sequence_length
1323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21522138, ECO:0000269|PubMed:23625947, ECO:0000269|PubMed:7512349}; Multi-pass membrane protein {ECO:0000305}. Postsynaptic cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 580..601; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O15399"; TRANSMEM 651..671; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O15399"; TRANSMEM 841..864; /note="Helical"; /evidence="ECO:0000250|UniProtKB:O15399
uniprot
proteins