RETREG3
entrez
162427
canonical
uniprot
Q86VR2
canonical
ensembl
ENSG00000141699
resolver
ensp
ENSP00000309432
resolver
ensp
ENSP00000467847
resolver
enst
ENST00000585894
resolver
genesymbol
RETREG3
resolver
genesymbol_syn
FAM134C
resolver
hgnc
HGNC:27258
resolver
uniprot
B3KR75
resolver
uniprot
K7EQI9
resolver
uniprot_entry
K7EQI9_HUMAN
resolver
uniprot_entry
RETR3_HUMAN
resolver
uniprot_sec
B3KR75
resolver
amino_acid_sequence
MAEAEGVPTTPGPASGSTFRGRRDVSGSWERDQQVEAAQRALVEVLGPYEPLLSRVQAALVWERPARSALWCLGLNAAFWFFALTSLRLVFLLAFGLMIIVCIDQWKNKIWPEIKVPRPDALDNESWGFVHPRLLSVPELCHHVAEVWVSGTIFIRNVLLFKKQNPGKFCLLSCGILTFLAVLGRYVPGLLLSYLMLVTVMMWPLAVYHRLWDRAYVRLKPALQRLDFSVRGYMMSKQRERQLRRRALHPERAMDNHSDSEEELAAFCPQLDDSTVARELAITDSEHSDAEVSCTDNGTFNLSRGQTPLTEGSEDLDGHSDPEESFARDLPDFPSINMDPAGLDDEDDTSIGMPSLMYRSPPGAEEPQAPPASRDEAALPELLLGALPVGSNLTSNLASLVSQGMIQLALSGASQPGPSGAPAQRATRGFLRSPSSDLDTDAEGDDFELLDQSELSQLDPASSRSH
uniprot
proteins
function
FUNCTION: Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Promotes ER membrane curvature and ER tubulation required for subsequent ER fragmentation and engulfment into autophagosomes (PubMed:33826365). Required for collagen quality control in a LIR motif-dependent manner (By similarity). Mediates NRF1-enhanced neurite outgrowth (PubMed:26040720). {ECO:0000250|UniProtKB:Q9CQV4, ECO:0000269|PubMed:26040720, ECO:0000269|PubMed:33826365, ECO:0000269|PubMed:34338405}.
uniprot
proteins
mass_dalton
51396
uniprot
proteins
mutagenesis
MUTAGEN 445..450; /note="DDFELL->AAAAAA: Reduced formation of autophagosomes."; /evidence="ECO:0000269|PubMed:33826365"; MUTAGEN 447..450; /note="FELL->AELA: Abolishes interaction with ATG8 family proteins, induction of ER fragmentation and ER degradation."; /evidence="ECO:0000269|PubMed:34338405
uniprot
proteins
protein_family
RETREG family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23939472
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26040720
uniprot
proteins
pubmed
33826365
uniprot
proteins
pubmed
34338405
uniprot
proteins
sequence_length
466
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:33826365, ECO:0000269|PubMed:34338405}; Multi-pass membrane protein {ECO:0000255}. Note=Localizes preferentially to endoplasmic reticulum tubules and sheet edges. {ECO:0000269|PubMed:33826365}.
uniprot
proteins
transmembrane_region
TRANSMEM 81..101; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 164..184; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 187..207; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 382..402; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins