Adarb1
entrez
110532
canonical
uniprot
Q91ZS8
canonical
ensembl
ENSMUSG00000020262
resolver
ensp
ENSMUSP00000020496
resolver
ensp
ENSMUSP00000095976
resolver
ensp
ENSMUSP00000256607
resolver
genesymbol
Adarb1
resolver
genesymbol_syn
Adar2
resolver
genesymbol_syn
Red1
resolver
uniprot
C3TTQ1
resolver
uniprot
Q3UHM7
resolver
uniprot
Q8K3X1
resolver
uniprot
Q91ZS6
resolver
uniprot
Q91ZS7
resolver
uniprot
Q91ZS9
resolver
uniprot
Q99MU8
resolver
uniprot_entry
RED1_MOUSE
resolver
uniprot_sec
C3TTQ1
resolver
uniprot_sec
Q3UHM7
resolver
uniprot_sec
Q8K3X1
resolver
uniprot_sec
Q91ZS6
resolver
uniprot_sec
Q91ZS7
resolver
uniprot_sec
Q91ZS9
resolver
uniprot_sec
Q99MU8
resolver
amino_acid_sequence
MDIEDEENMSSSSTDIKENRNLDNMPPKDSSTPGPGEGIPLSNGGGGSTSRKRPLEEGSNGHSKYRLKKRRKTPGPVLPKNALMQLNEIKPGLQYMLLSQTGPVHAPLFVMSVEVNGQVFEGSGPTKKKAKLHAAEKALRSFVQFPNASEAHLAMGRTLSVNTDFTSDQADFPDTLFNGFETPDKSEPPFYVGSNGDDSFSSSGDVSLSASPVPASLTQPPLPIPPPFPPPSGKNPVMILNELRPGLKYDFLSESGESHAKSFVMSVVVDGQFFEGSGRNKKLAKARAAQSALATVFNLHLDQTPSRQPVLSEGLQLHLPQVLADAVSRLVLGKFSDLTDNFSSPHARRKVLSGVVMTTGTDVKDAKVISVSTGTKCINGEYMSDRGLALNDCHAEIISRRSLLRFLYAQLELYLNNKEDQKKSIFQKSERGGFRLKDTVQFHLYISTSPCGDARIFSPHEPVLEGMTPDSHQLTEPADRHPNRKARGQLRTKIESGEGTIPVRSNASIQTWDGVLQGERLLTMSCSDKIARWNVVGIQGSLLSIFVEPIYFSSIILGSLYHGDHLSRAMYQRISNIEDLPPLYTLNKPLLSGISNAEARQPGKAPNFSVNWTVGDATIEVINATTGKDELGRPSRLCKHALYCRWMRVHGKVPPHLLRTKITKPTTYHESKLAAREYQAAKARLFTAFIKAGLGAWVEKPTEQDQFSFTP
uniprot
proteins
ec_number
3.5.4.37
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can inhibit cell proliferation and migration and can stimulate exocytosis. {ECO:0000269|PubMed:17369310, ECO:0000269|PubMed:33100268}.
uniprot
proteins
mass_dalton
78001
uniprot
proteins
pubmed
12709013
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17369310
uniprot
proteins
pubmed
19156214
uniprot
proteins
pubmed
20946981
uniprot
proteins
pubmed
21182352
uniprot
proteins
pubmed
33100268
uniprot
proteins
sequence_length
711
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P78563}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P78563}. Note=Shuttles between nucleoli and the nucleoplasm. {ECO:0000250|UniProtKB:P78563}.
uniprot
proteins