Cnot7
entrez
18983
canonical
uniprot
Q60809
canonical
ensembl
ENSMUSG00000031601
resolver
ensp
ENSMUSP00000034012
resolver
ensp
ENSMUSP00000117304
resolver
ensp
ENSMUSP00000119319
resolver
ensp
ENSMUSP00000122933
resolver
ensp
ENSMUSP00000294797
resolver
ensp
ENSMUSP00000294814
resolver
enst
ENSMUST00000034012
resolver
enst
ENSMUST00000132032
resolver
enst
ENSMUST00000135269
resolver
enst
ENSMUST00000149992
resolver
genesymbol
Cnot7
resolver
genesymbol_syn
Caf1
resolver
uniprot
F6Q8Q9
resolver
uniprot
Q3TLK9
resolver
uniprot
Q543X5
resolver
uniprot_entry
CNOT7_MOUSE
resolver
uniprot_entry
F6Q8Q9_MOUSE
resolver
uniprot_entry
Q3TLK9_MOUSE
resolver
uniprot_entry
Q543X5_MOUSE
resolver
amino_acid_sequence
MPAATVDHSQRICEVWACNLDEEMKKIRQVIRKYNYVAMDTEFPGVVARPIGEFRSNADYQYQLLRCNVDLLKIIQLGLTFMNEQGEYPPGTSTWQFNFKFNLTEDMYAQDSIELLTTSGIQFKKHEEEGIETQYFAELLMTSGVVLCEGVKWLSFHSGYDFGYLIKILTNSNLPEEELDFFEILRLFFPVIYDVKYLMKSCKNLKGGLQEVAEQLELERIGPQHQAGSDSLLTGMAFFKMREMFFEDHIDDAKYCGHLYGLGSGSSYVQNGTGNAYEEEASKQS
uniprot
proteins
ec_number
3.1.13.4
uniprot
proteins
function
FUNCTION: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex also seems to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for miRNA-mediated mRNA deadenylation. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. {ECO:0000269|PubMed:19716330, ECO:0000269|PubMed:22367759}.
uniprot
proteins
mass_dalton
32718
uniprot
proteins
mutagenesis
MUTAGEN 203; /note="K->A: Severe decrease of interaction with BTG4."; /evidence="ECO:0000269|PubMed:27065194
uniprot
proteins
protein_family
CAF1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19716330
uniprot
proteins
pubmed
20133598
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22367759
uniprot
proteins
pubmed
27065194
uniprot
proteins
pubmed
7791755
uniprot
proteins
pubmed
9712883
uniprot
proteins
sequence_length
285
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20133598}. Cytoplasm, P-body {ECO:0000269|PubMed:20133598}. Cytoplasm, Cytoplasmic ribonucleoprotein granule {ECO:0000250|UniProtKB:Q9UIV1}. Note=NANOS2 promotes its localization to P-body (PubMed:20133598). Recruited to cytoplasmic ribonucleoprotein membraneless compartments by CAPRIN1, promoting deadenylation of mRNAs (By similarity). {ECO:0000250|UniProtKB:Q9UIV1, ECO:0000269|PubMed:20133598}.
uniprot
proteins