Tmprss4
entrez
214523
canonical
uniprot
Q8VCA5
canonical
ensembl
ENSMUSG00000032091
resolver
ensp
ENSMUSP00000034599
resolver
enst
ENSMUST00000034599
resolver
genesymbol
Tmprss4
resolver
genesymbol_syn
Cap2
resolver
uniprot_entry
TMPS4_MOUSE
resolver
amino_acid_sequence
MESDSGQPLNNRDIVPFRKPRRPQETFKKVGIPIIAVLLSLIALVIVALLIKVILDKYYFICGSPLTFIQRGQLCDGHLDCASGEDEEHCVKDFPEKPGVAVRLSKDRSTLQVLDAATGTWASVCFDNFTEALAKTACRQMGYDSQPAFRAVEIRPDQNLPVAQVTGNSQELQVQNGSRSCLSGSLVSLRCLDCGKSLKTPRVVGGVEAPVDSWPWQVSIQYNKQHVCGGSILDPHWILTAAHCFRKYLDVSSWKVRAGSNILGNSPSLPVAKIFIAEPNPLYPKEKDIALVKLQMPLTFSGSVRPICLPFSDEVLVPATPVWVIGWGFTEENGGKMSDMLLQASVQVIDSTRCNAEDAYEGEVTAEMLCAGTPQGGKDTCQGDSGGPLMYHSDKWQVVGIVSWGHGCGGPSTPGVYTKVTAYLNWIYNVRKSEM
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity (By similarity). Seems to be capable of activating ENaC (PubMed:12149280). {ECO:0000250|UniProtKB:Q9NRS4, ECO:0000269|PubMed:12149280}.
uniprot
proteins
mass_dalton
47496
uniprot
proteins
post_translational_modification
PTM: Proteolytically processed; probably by an autocatalytic mechanism. {ECO:0000250|UniProtKB:Q9NRS4}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
12149280
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
435
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9NRS4}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q9NRS4}.; SUBCELLULAR LOCATION: [Transmembrane protease serine 4 catalytic chain]: Secreted {ECO:0000250|UniProtKB:Q9NRS4}. Note=Activated by cleavage and secreted. {ECO:0000250|UniProtKB:Q9NRS4}.
uniprot
proteins
transmembrane_region
TRANSMEM 31..51; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins