Brox
entrez
305031
canonical
uniprot
Q4V8K5
canonical
ensembl
ENSRNOG00000052963
resolver
ensembl
ENSRNOG00055011968
resolver
ensembl
ENSRNOG00060007841
resolver
ensembl
ENSRNOG00065017859
resolver
ensp
ENSRNOP00000073617
resolver
ensp
ENSRNOP00055016411
resolver
ensp
ENSRNOP00060009814
resolver
ensp
ENSRNOP00065023741
resolver
enst
ENSRNOT00000078834
resolver
enst
ENSRNOT00055020352
resolver
enst
ENSRNOT00060012938
resolver
enst
ENSRNOT00065029896
resolver
genesymbol
Brox
resolver
uniprot_entry
BROX_RAT
resolver
amino_acid_sequence
MTHWFHRNPLKATAPVSFNYYGMITGPPASKICNDLRSARTRLLELFTDLSCNPETMKNAADLYFSLLQGFINSVGDSTQESKLRYIQNFKWTDTLQGHVPSAQQDAVFELISMGFNVALWYTKYASRLAGKENITEDEAKEVHRSLKIAAGIFKHLKESHIPKLLTPAEKGRDLEARLIDAYIIQCQAEAQEVTIARAIELKHAPGLIAALAYETASFYQKADHTLSSLEPAHSAKWRKYLHLKMCFYTAYAYCYHGQTLLASDKCGEAIRSLQEAEKLYAEAEALCKEYGETKGPGPTAKPSGHLFFRKLGSLVKNTLDKCQRENGFIYFQKIPTEAPQLELKANYGLVEPVPFEFPPMSALWTPEALAAFDLTKRPKDDSIKPKPEEEVKPVKEPDIKPQKDTGCSVS
uniprot
proteins
function
FUNCTION: Nuclear envelope-associated factor that is involved in the nuclear envelope ruptures during interphase (NERDI) repair, where it is locally recruited by CHMP5 and reduces cytoskeletal stress through its action on SYN2 to help reseal the ruptured membrane. {ECO:0000250|UniProtKB:Q5VW32}.
uniprot
proteins
mass_dalton
46192
uniprot
proteins
post_translational_modification
PTM: Farnesylation is required for nuclear envelope localization. {ECO:0000250|UniProtKB:Q5VW32}.
uniprot
proteins
protein_family
BROX family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
411
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250|UniProtKB:Q5VW32}; Lipid-anchor {ECO:0000250|UniProtKB:Q5VW32}. Note=During nuclear envelope repair, localizes at rupture sites where it is recruited by the CHMP7/ESCRT-III axis. {ECO:0000250|UniProtKB:Q5VW32}.
uniprot
proteins