Gosr1
entrez
94189
canonical
uniprot
Q62931
canonical
ensembl
ENSRNOG00000070572
resolver
ensembl
ENSRNOG00055028761
resolver
ensembl
ENSRNOG00060026558
resolver
ensembl
ENSRNOG00065022205
resolver
ensp
ENSRNOP00000082876
resolver
ensp
ENSRNOP00055041095
resolver
ensp
ENSRNOP00060038320
resolver
ensp
ENSRNOP00065030648
resolver
enst
ENSRNOT00000107339
resolver
enst
ENSRNOT00055049898
resolver
enst
ENSRNOT00060046131
resolver
enst
ENSRNOT00065037890
resolver
genesymbol
Gosr1
resolver
genesymbol_syn
Gs28
resolver
uniprot
A0JN01
resolver
uniprot_entry
GOSR1_RAT
resolver
uniprot_sec
A0JN01
resolver
amino_acid_sequence
MAAGTSNYWEDLRKQARQLENELDLKLVSFSKLCTSYSHSSARDGGRDRYSSDTTPLLNGSSQDRMFETMAIEIEQLLARLTGVNDKMAEYTHSAGVPSLNAALMHTLQRHRDILQDYTHEFHKTKANFMAIRERENLMGSVRKDIESYKSGSGVNNRRTELFLKEHDHLRNSDRLIEETISIAMATKENMTSQRGMLKSIHSKMNTLANRFPAVNSLIQRINLRKRRDSLILGGVIGICTILLLLYAFH
uniprot
proteins
function
FUNCTION: Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi. {ECO:0000269|PubMed:14742712, ECO:0000269|PubMed:20450495, ECO:0000269|PubMed:8638159}.
uniprot
proteins
mass_dalton
28534
uniprot
proteins
protein_family
GOSR1 family
uniprot
proteins
pubmed
10585748
uniprot
proteins
pubmed
10747018
uniprot
proteins
pubmed
11323436
uniprot
proteins
pubmed
11748249
uniprot
proteins
pubmed
11927603
uniprot
proteins
pubmed
12388752
uniprot
proteins
pubmed
14742712
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15728195
uniprot
proteins
pubmed
18648846
uniprot
proteins
pubmed
20450495
uniprot
proteins
pubmed
8638159
uniprot
proteins
pubmed
9094723
uniprot
proteins
pubmed
9382863
uniprot
proteins
pubmed
9647643
uniprot
proteins
sequence_length
250
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000269|PubMed:10585748, ECO:0000269|PubMed:10747018, ECO:0000269|PubMed:11323436, ECO:0000269|PubMed:11748249, ECO:0000269|PubMed:11927603, ECO:0000269|PubMed:12388752, ECO:0000269|PubMed:14742712, ECO:0000269|PubMed:18648846, ECO:0000269|PubMed:20450495, ECO:0000269|PubMed:9382863, ECO:0000269|PubMed:9647643}; Single-pass type IV membrane protein {ECO:0000269|PubMed:10585748, ECO:0000269|PubMed:10747018, ECO:0000269|PubMed:11323436, ECO:0000269|PubMed:11748249, ECO:0000269|PubMed:11927603, ECO:0000269|PubMed:12388752, ECO:0000269|PubMed:14742712, ECO:0000269|PubMed:18648846, ECO:0000269|PubMed:20450495, ECO:0000269|PubMed:9382863, ECO:0000269|PubMed:9647643}. Note=Localizes throughout the Golgi apparatus, with lowest levels in the trans-Golgi network. Enriched on vesicular components at the terminal rims of the Golgi apparatus.
uniprot
proteins
transmembrane_region
TRANSMEM 230..250; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins