Tcf7l2
entrez
21416
canonical
uniprot
Q924A0
canonical
ensembl
ENSMUSG00000024985
resolver
ensp
ENSMUSP00000042950
resolver
ensp
ENSMUSP00000050081
resolver
ensp
ENSMUSP00000107273
resolver
ensp
ENSMUSP00000107283
resolver
ensp
ENSMUSP00000107284
resolver
ensp
ENSMUSP00000107286
resolver
ensp
ENSMUSP00000107287
resolver
ensp
ENSMUSP00000118661
resolver
ensp
ENSMUSP00000123428
resolver
ensp
ENSMUSP00000209431
resolver
ensp
ENSMUSP00000209432
resolver
ensp
ENSMUSP00000209433
resolver
ensp
ENSMUSP00000209434
resolver
ensp
ENSMUSP00000330402
resolver
enst
ENSMUST00000041717
resolver
enst
ENSMUST00000061496
resolver
enst
ENSMUST00000111656
resolver
enst
ENSMUST00000111657
resolver
enst
ENSMUST00000111658
resolver
enst
ENSMUST00000111659
resolver
enst
ENSMUST00000127233
resolver
genesymbol
Tcf7l2
resolver
genesymbol_syn
Tcf4
resolver
uniprot
A0A0R4J1G0
resolver
uniprot
D3YWT3
resolver
uniprot
E9Q990
resolver
uniprot
E9QQ90
resolver
uniprot
E9QQ91
resolver
uniprot
F6WBK9
resolver
uniprot
F6WPX2
resolver
uniprot
O70574
resolver
uniprot
Q8BS68
resolver
uniprot
Q8C834
resolver
uniprot
Q8CAI6
resolver
uniprot
Q91XP2
resolver
uniprot
Q91XP3
resolver
uniprot
Q91XP4
resolver
uniprot
Q924A1
resolver
uniprot
Q9Z0V3
resolver
uniprot
Q9Z0V4
resolver
uniprot_entry
A0A0R4J1G0_MOUSE
resolver
uniprot_entry
D3YWT3_MOUSE
resolver
uniprot_entry
E9Q990_MOUSE
resolver
uniprot_entry
E9QQ90_MOUSE
resolver
uniprot_entry
E9QQ91_MOUSE
resolver
uniprot_entry
F6WBK9_MOUSE
resolver
uniprot_entry
F6WPX2_MOUSE
resolver
uniprot_entry
Q8BS68_MOUSE
resolver
uniprot_entry
Q8CAI6_MOUSE
resolver
uniprot_entry
TF7L2_MOUSE
resolver
uniprot_sec
O70574
resolver
uniprot_sec
Q8C834
resolver
uniprot_sec
Q91XP2
resolver
uniprot_sec
Q91XP3
resolver
uniprot_sec
Q91XP4
resolver
uniprot_sec
Q924A1
resolver
uniprot_sec
Q9Z0V3
resolver
uniprot_sec
Q9Z0V4
resolver
amino_acid_sequence
MPQLNGGGGDDLGANDELISFKDEGEQEEKNSENSSAERDLADVKSSLVNESETNQDSSSDSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPGYPFIMIPDLTSPYLPNGSLSPTARTYLQMKWPLLDVQAGSLQSRQTLKDARSPSPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNPCLSLPPITDLSAPKKCRARFGLDQQNNWCGPCSL
uniprot
proteins
disease_involvement
DISEASE: Note=Constitutive activation and subsequent transactivation of target genes may lead to the maintenance of stem-cell characteristics (cycling and longevity) in cells that should normally undergo terminal differentiation and constitute the primary transforming event in colorectal cancer (CRC).
uniprot
proteins
function
FUNCTION: Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as a repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif CCTTTGATC in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1 (By similarity). Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. {ECO:0000250, ECO:0000269|PubMed:21856776, ECO:0000269|PubMed:9697701}.
uniprot
proteins
mass_dalton
51217
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Thr-178 and/or Thr-189 by NLK. Phosphorylation by NLK at these sites inhibits DNA-binding by TCF7L2/TCF4, thereby preventing transcriptional activation of target genes of the canonical Wnt/beta-catenin signaling pathway (By similarity). {ECO:0000250}.; PTM: Polysumoylated. Sumoylation is enhanced by PIAS family members and desumoylation is enhanced by SENP2. Sumoylation/desumoylation regulates TCF7L2/TCF4 transcription activity in the Wnt/beta-catenin signaling pathway without altering interaction with CTNNB1 nor binding to DNA (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
TCF/LEF family
uniprot
proteins
pubmed
11845287
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16291758
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19816403
uniprot
proteins
pubmed
21856776
uniprot
proteins
pubmed
9488439
uniprot
proteins
pubmed
9697701
uniprot
proteins
pubmed
9880534
uniprot
proteins
sequence_length
459
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, PML body {ECO:0000250|UniProtKB:Q9NQB0}. Nucleus {ECO:0000250|UniProtKB:Q9NQB0}. Note=Diffuse pattern. Colocalizes with SUMO1 and PIAS4 in a subset of PML (promyelocytic leukemia) nuclear bodies (By similarity). {ECO:0000250|UniProtKB:Q9NQB0}.
uniprot
proteins