ASB11
entrez
140456
canonical
uniprot
Q8WXH4
canonical
ensembl
ENSG00000165192
resolver
ensp
ENSP00000343408
resolver
ensp
ENSP00000369837
resolver
ensp
ENSP00000417914
resolver
genesymbol
ASB11
resolver
hgnc
HGNC:17186
resolver
uniprot
E9PEN1
resolver
uniprot
Q3SYC4
resolver
uniprot
Q7Z667
resolver
uniprot_entry
ASB11_HUMAN
resolver
uniprot_sec
E9PEN1
resolver
uniprot_sec
Q3SYC4
resolver
uniprot_sec
Q7Z667
resolver
amino_acid_sequence
MEDGPVFYGFKNIFITMFATFFFFKLLIKVFLALLTHFYIVKGNRKEAARIAEEIYGGISDCWADRSPLHEAAAQGRLLALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSALDLAAPKSSVEQALLLREGPPALSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLLYQ
uniprot
proteins
function
FUNCTION: Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as BIK, DIRAS2 and RPN1 (PubMed:24337577, PubMed:31387940, PubMed:38574733). The ECS(ASB11) complex acts as a regulator of the endoplasmic reticulum unfolded protein response by mediating ubiquitination and degradation of BIK (PubMed:31387940). {ECO:0000269|PubMed:24337577, ECO:0000269|PubMed:31387940, ECO:0000269|PubMed:38574733}.
uniprot
proteins
mass_dalton
35367
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:24337577, ECO:0000269|PubMed:31387940, ECO:0000269|PubMed:38574733}.
uniprot
proteins
protein_family
Ankyrin SOCS box (ASB) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
23033978
uniprot
proteins
pubmed
24337577
uniprot
proteins
pubmed
31387940
uniprot
proteins
pubmed
38574733
uniprot
proteins
sequence_length
323
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000269|PubMed:24337577}.
uniprot
proteins