TRAF7
entrez
84231
canonical
uniprot
Q6Q0C0
canonical
ensembl
ENSG00000131653
resolver
ensp
ENSP00000318944
resolver
ensp
ENSP00000515904
resolver
ensp
ENSP00000580836
resolver
genesymbol
TRAF7
resolver
genesymbol_syn
RFWD1
resolver
genesymbol_syn
RNF119
resolver
hgnc
HGNC:20456
resolver
uniprot
B3KQY7
resolver
uniprot
Q9H073
resolver
uniprot_entry
B3KQY7_HUMAN
resolver
uniprot_entry
TRAF7_HUMAN
resolver
uniprot_sec
Q9H073
resolver
amino_acid_sequence
MSSGKSARYNRFSGGPSNLPTPDVTTGTRMETTFGPAFSAVTTITKADGTSTYKQHCRTPSSSSTLAYSPRDEEDSMPPISTPRRSDSAISVRSLHSESSMSLRSTFSLPEEEEEPEPLVFAEQPSVKLCCQLCCSVFKDPVITTCGHTFCRRCALKSEKCPVDNVKLTVVVNNIAVAEQIGELFIHCRHGCRVAGSGKPPIFEVDPRGCPFTIKLSARKDHEGSCDYRPVRCPNNPSCPPLLRMNLEAHLKECEHIKCPHSKYGCTFIGNQDTYETHLETCRFEGLKEFLQQTDDRFHEMHVALAQKDQEIAFLRSMLGKLSEKIDQLEKSLELKFDVLDENQSKLSEDLMEFRRDASMLNDELSHINARLNMGILGSYDPQQIFKCKGTFVGHQGPVWCLCVYSMGDLLFSGSSDKTIKVWDTCTTYKCQKTLEGHDGIVLALCIQGCKLYSGSADCTIIVWDIQNLQKVNTIRAHDNPVCTLVSSHNVLFSGSLKAIKVWDIVGTELKLKKELTGLNHWVRALVAAQSYLYSGSYQTIKIWDIRTLDCIHVLQTSGGSVYSIAVTNHHIVCGTYENLIHVWDIESKEQVRTLTGHVGTVYALAVISTPDQTKVFSASYDRSLRVWSMDNMICTQTLLRHQGSVTALAVSRGRLFSGAVDSTVKVWTC
uniprot
proteins
disease_involvement
DISEASE: Cardiac, facial, and digital anomalies with developmental delay (CAFDADD) [MIM:618164]: An autosomal dominant disorder characterized by delayed motor and speech development, developmental regression, congenital heart defects, limb and digital anomalies, and dysmorphic features. Cardiac features include pulmonary stenosis, patent ductus arteriosus, aortic coarctation, valvular defects, hypoplastic left heart, double outlet right ventricle, and conduction abnormalities. Dysmorphic facial features include multiple hair whorls or hairline abnormalities, ptosis, epicanthal folds, and low-set or dysplastic ears. {ECO:0000269|PubMed:29961569}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.3.2.-
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin and SUMO-protein ligase that plays a role in different biological processes such as innate immunity, inflammation or apoptosis (PubMed:15001576, PubMed:37086853). Potentiates MAP3K3-mediated activation of JUN/AP1 and DDIT3 transcriptional regulators (PubMed:14743216). Negatively regulates MYB transcriptional activity by sequestering it to the cytosol via SUMOylation (By similarity). Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3. Negatively regulates RLR-mediated innate immunity by promoting 'Lys-48'-linked ubiquitination of TBK1 through its RING domain to inhibit the cellular antiviral response (PubMed:37086853). Promotes 'Lys-29'-linked polyubiquitination of NEMO/IKBKG and RELA leading to targeting these two proteins to lysosomal degradative pathways, reducing the transcriptional activity of NF-kappa-B (PubMed:21518757). {ECO:0000250|UniProtKB:Q922B6, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:15001576, ECO:0000269|PubMed:21518757, ECO:0000269|PubMed:29961569, ECO:0000269|PubMed:37086853}.
uniprot
proteins
mass_dalton
74609
uniprot
proteins
mutagenesis
MUTAGEN 131; /note="C->S: Complete loss of IFN-beta promoter inhibition after viral infection."; /evidence="ECO:0000269|PubMed:37086853
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MAP3K3. {ECO:0000269|PubMed:14743216}.; PTM: Ubiquitinates itself upon phosphorylation.
uniprot
proteins
protein_family
WD repeat TRAF7 family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14743216
uniprot
proteins
pubmed
15001576
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
21518757
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
29961569
uniprot
proteins
pubmed
37086853
uniprot
proteins
sequence_length
670
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000269|PubMed:14743216}. Cytoplasm {ECO:0000269|PubMed:21518757, ECO:0000269|PubMed:37086853}. Nucleus {ECO:0000269|PubMed:37086853}. Note=Colocalizes with MAP3K3 to vesicle-like structures throughout the cytoplasm.
uniprot
proteins