Scn7a
entrez
64155
canonical
uniprot
F1LQQ7
canonical
ensembl
ENSRNOG00000029342
resolver
ensp
ENSRNOP00000044385
resolver
genesymbol
Scn7a
resolver
genesymbol_syn
Scl11
resolver
uniprot
P97706
resolver
uniprot
Q01340
resolver
uniprot
Q64074
resolver
uniprot_entry
SCN7A_RAT
resolver
uniprot_sec
P97706
resolver
uniprot_sec
Q01340
resolver
uniprot_sec
Q64074
resolver
amino_acid_sequence
MLTSPEPKGLVPFTAESLELIKNHIAKKCNEEHEEEDLKPSWGLEAGKKLPFAYGTLPQGTVSEPLEDVDPYYYVKRNTFMVLNRNRVIFRFNAVSILCTLSPLSSLRRAVIKVLVHPLFRLLILISVLTDSILMCMSNLPEWILAVENTLLGIYTFEILVKVIARGIWAGSFSFLGDLWNWLDFSVTLFELITRSSPLSSLPMFKTIRTLRILKIIPLNHGLQSIVVTLVQCLKKLLGAIALALFFLTVSSLFGMGLFMGNLKHKCVRWPQEDGNDVMYNGTGSQYHILERENFYYMEGARYALLCGNKTDAGLCPEGYMCVKEGSNPDNGFTSFDNFGWALLAMFRLMTQDYPELLYHQILYASGKIYMIFFVLISFWFAFYMASLFLGILTMAYEQEKQRASEESRDMDSKCHQTVKEFEEEHEGAEMETTQIEMKKRSPTSINTTLDILEDTALGHKEEPETSRKECPLCWYKFTKTCFIWKCSPCWIKLNEFADRIITHPLFDLFLVICIILNICFLALEHFPMSEELMSLLAIGNLVFIGIYTIEMILKIIAMHPYGYFQISWHIFDSILVVLGLTEMLLADIEEITVFILVPLIFIKLGKYAPPFKNLMRILGRALVALKDLVLLVSIFIYFSAVFGMKLFGRSYKDCVCHVDQDCQRQRWHMSDFLHAYVTVFRILCGEWIETLWECMEVAGEAWCIPFYMMVILIGNLLILYLFVALVSSFASYDATTEVSKEAKNLQLAVAWIKMVINCVLLKILCKEKTVSTEATDQTCDPSVKENISGHTLSELSNTQTFLRYKDQSSGTEKTPVTESESQSLIASPSVSETVPIASGESDIENLDNKETRSKSANGSSKEKMKQSSSSECSTVDIAISEEEEMVYEHEKSKLHKNGYERKSSAGQVSRESRNGKIWRNIRKTCCKIVENSWFECFIGLVTLLCTGTLALEDIYIDQRKTIKIFLEYGDMIFAYIFILEMLLKWVAYGFKAYFSNNWYKLDFMVVIVLCLSLIGKTREDLNPLASIKFLRALRVLSQFERMKVVLRALIKTTLPAVSVFLVCLMIWLLFSVMGVFLFAGKFYECIDPTRGERFSVFEVMNKSQCENLVFNESMPWENAKLNFDNVGNGFLSLFQVATFNGWISIMNSAIDSVGVYMQPSFEHSLHMYTYFIIFVVFGLFLPLCMLIGVIIRNFNKQKIKQGGSNIFITVKQKKQYRALKKLLYADSQKPAARPRNKFQGFICDVVTHRVFNVIIILLICFQATTIMIQNDEQSPQIETAVFWMNSLFTMLFTLECILKLTAFRCHYFTSAWNVHDFMVVVFSITGLLLPLSIGQYFVPPSLVQLLLLSRIIHVLRPGKGPKVFHDLMLPLMLSLPALLNIALLIFLVMFIYAIFGMYNFAYVKKEAGINDVSNFETFGSSMLCLFQVTTFSGWDGMLDAIFNSQWSDCDPDKINPGTQVRGDCGSPSVGIFYFVSYILISWLIIVNMYVVLIMEFLSIPSKRKNRTLSEDDFRRFFKVWNRFDPDRTQYIDSTKLSDFAAALDPPLFMAKPNKGQLVAMDLPMAAGDRIHCLDILLAFTKRVMGKDERVEKILSEIESGFMLANPFKITYEPITTTLKRKQEAVSATIIQRAYKSYRLRQSDKKIQDIPEIDDGREDPNSKGVHSGQIEEKASIQTQI
uniprot
proteins
function
FUNCTION: Sodium leak channel functioning as an osmosensor regulating sodium ion levels in various tissues and organs. While most sodium channels are voltage-gated, SCN7A is not and lets sodium flow through membrane along its concentration gradient (PubMed:21084682, PubMed:9001394). In glial cells of the central nervous system, senses body-fluid sodium levels and controls salt intake behavior as well as voluntary water intake through activation of nearby neurons to maintain appropriate sodium levels in the body (By similarity). By mediating sodium influx into keratinocytes, also plays a role in skin barrier homeostasis (By similarity). {ECO:0000250|UniProtKB:B1AYL1, ECO:0000250|UniProtKB:Q01118, ECO:0000269|PubMed:21084682, ECO:0000269|PubMed:9001394}.
uniprot
proteins
mass_dalton
192136
uniprot
proteins
protein_family
SCN7A subfamily
uniprot
proteins
protein_family
Sodium channel (TC 1.A.1.10) family
uniprot
proteins
pubmed
1379737
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
21084682
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9001394
uniprot
proteins
sequence_length
1680
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q01118}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 118..137; /note="Helical; Name=S1 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 142..167; /note="Helical; Name=S2 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 179..196; /note="Helical; Name=S3 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 201..219; /note="Helical; Name=S4 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 238..259; /note="Helical; Name=S5 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 368..407; /note="Helical; Name=S6 of repeat I"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 506..521; /note="Helical; Name=S1 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 531..559; /note="Helical; Name=S2 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 569..586; /note="Helical; Name=S3 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 593..608; /note="Helical; Name=S4 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 626..654; /note="Helical; Name=S5 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 701..731; /note="Helical; Name=S6 of repeat II"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 934..952; /note="Helical; Name=S1 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 961..989; /note="Helical; Name=S2 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 998..1019; /note="Helical; Name=S3 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 1021..1039; /note="Helical; Name=S4 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 1055..1079; /note="Helical; Name=S5 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 1167..1201; /note="Helical; Name=S6 of repeat III"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 1250..1271; /note="Helical; Name=S1 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 1276..1304; /note="Helical; Name=S2 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 1312..1337; /note="Helical; Name=S3 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 1341..1361; /note="Helical; Name=S4 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 1377..1401; /note="Helical; Name=S5 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q01118"; TRANSMEM 1468..1503; /note="Helical; Name=S6 of repeat IV"; /evidence="ECO:0000250|UniProtKB:Q01118
uniprot
proteins