Trim26
entrez
22670
canonical
uniprot
Q99PN3
canonical
ensembl
ENSMUSG00000024457
resolver
ensp
ENSMUSP00000060103
resolver
ensp
ENSMUSP00000114896
resolver
ensp
ENSMUSP00000325984
resolver
genesymbol
Trim26
resolver
genesymbol_syn
Znf173
resolver
uniprot
B8JJ55
resolver
uniprot
Q3UFX3
resolver
uniprot
Q8C9E9
resolver
uniprot
Q8JZT7
resolver
uniprot
Q99PN2
resolver
uniprot_entry
Q3UFX3_MOUSE
resolver
uniprot_entry
TRI26_MOUSE
resolver
uniprot_sec
B8JJ55
resolver
uniprot_sec
Q8C9E9
resolver
uniprot_sec
Q8JZT7
resolver
uniprot_sec
Q99PN2
resolver
amino_acid_sequence
MAVSAPLRSLEEEVTCSICLDYLRDPVTIDCGHVFCRSCTSDIRPISGNRPVCPLCKKPFKKENIRPVWQLASLVENIERLKVDNGRQPGELAREPQDMKLCERHQEKLHYYCEDDGKLLCVMCRESREHRPHTAVLVEKAALPHREKILNHLNTLRRDRDKIQGFQAKGEADILAALTKLQEQRQYIVAEFKQGHQFLKKREQHLLDQLATLEQLLTEGREKFKTRGVSELDRLTLVISELEGKARQPAAELMQDVCTTQDTKDFANKYPRKKFWIGKAIPHMVKRKAGEFSDKLLSLQRGLRQFQGKLLRDLEYKTVSVTLDPQSASGYLHLSEDWKCVTYTGQYQSDCLLPQQFDCEPGVLGSKGFTWGKVYWEVELEREGWSEDEEEGEEEEEGEEEEEDEEVGYGDGYEDWETDEEDESLGEEEEEEEEEEEEVQESCMVGVAKDSVKRKGDLSLRPEDGVWALRLSPSGIWANTSPEAQLFPVLRPRRVGIALDYEGGTVTFTNAESQELIYTFTTTFTRRLVPFLWLKWPGARLLLRP
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Also plays a central role in determining the response to different forms of oxidative stress by controlling levels of DNA glycosylases NEIL1, NEIL3 and NTH1 that are involved in repair of damaged DNA. Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1. Positively regulates LPS-mediated inflammatory innate immune response by catalyzing the 'Lys-11'-linked polyubiquitination of TAB1 to enhance its activation and subsequent NF-kappa-B and MAPK signaling (PubMed:34017102). In a manner independent of its catalytic activity, inhibits WWP2, a SOX2-directed E3 ubiquitin ligase, and thus protects SOX2 from polyubiquitination and proteasomal degradation. Ubiquitinates the histone acetyltransferase protein complex component PHF20 and thereby triggers its degradation in the nucleus after its recruitment by the histone demethylase KDM6B, serving as a scaffold protein. Upon induction by TGF-beta, ubiquitinates the TFIID component TAF7 for proteasomal degradation (By similarity). Induces ferroptosis by ubiquitinating SLC7A11, a critical protein for lipid reactive oxygen species (ROS) scavenging (PubMed:33869196). {ECO:0000250|UniProtKB:Q12899, ECO:0000269|PubMed:33869196, ECO:0000269|PubMed:34017102}.
uniprot
proteins
mass_dalton
62809
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinates upon viral infection. In turn, autoubiquitinated TRIM26 recruits NEMO and bridges TBK1-NEMO interaction. {ECO:0000250|UniProtKB:Q12899}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
33869196
uniprot
proteins
pubmed
34017102
uniprot
proteins
sequence_length
545
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q12899}. Nucleus {ECO:0000250|UniProtKB:Q12899}. Note=Viral infection mediates TRIM26 nuclear translocation. {ECO:0000250|UniProtKB:Q12899}.
uniprot
proteins