Adam2
entrez
11495
canonical
uniprot
Q60718
canonical
ensembl
ENSMUSG00000022039
resolver
ensp
ENSMUSP00000022618
resolver
enst
ENSMUST00000022618
resolver
genesymbol
Adam2
resolver
genesymbol_syn
Ftnb
resolver
uniprot
Q60814
resolver
uniprot
Q9D4G3
resolver
uniprot
Q9QWJ0
resolver
uniprot_entry
ADAM2_MOUSE
resolver
uniprot_sec
Q60814
resolver
uniprot_sec
Q9D4G3
resolver
uniprot_sec
Q9QWJ0
resolver
amino_acid_sequence
MWLILLLLSGLSELGGLSQSQTEGTREKLHVQVTVPEKIRSVTSNGYETQVTYNLKIEGKTYTLDLMQKPFLPPNFRVYSYDNAGIMRSLEQKFQNICYFQGYIEGYPNSMVIVSTCTGLRGFLQFGNVSYGIEPLESSSGFEHVIYQVEPEKGGALLYAEKDIDLRDSQYKIRSIKPQRIVSHYLEIHIVVEKQMFEHIGADTAIVTQKIFQLIGLANAIFAPFNLTVILSSLEFWMDENKILTTGDANKLLYRFLKWKQSYLVLRPHDMAFLLVYRNTTDYVGATYQGKMCDKNYAGGVALHPKAVTLESLAIILVQLLSLSMGLAYDDVNKCQCGVPVCVMNPEAPHSSGVRAFSNCSMEDFSKFITSQSSHCLQNQPRLQPSYKMAVCGNGEVEEDEICDCGKKGCAEMPPPCCNPDTCKLSDGSECSSGICCNSCKLKRKGEVCRLAQDECDVTEYCNGTSEVCEDFFVQNGHPCDNRKWICINGTCQSGEQQCQDLFGIDAGFGSSECFWELNSKSDISGSCGISAGGYKECPPNDRMCGKIICKYQSENILKLRSATVIYANISGHVCVSLEYPQGHNESQKMWVRDGTVCGSNKVCQNQKCVADTFLGYDCNLEKCNHHGVCNNKKNCHCDPTYLPPDCKRMKDSYPGGSIDSGNKERAEPIPVRPYIASAYRSKSPRWPFFLIIPFYVVILVLIGMLVKVYSQRMKWRMDDFSSEEQFESESESKD
uniprot
proteins
function
FUNCTION: Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
82375
uniprot
proteins
post_translational_modification
PTM: The signal and the metalloprotease domain are cleaved during the epididymal maturation of the spermatozoa.
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20945367
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7593287
uniprot
proteins
pubmed
7750654
uniprot
proteins
sequence_length
735
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 687..707; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins