TYK2
entrez
7297
canonical
uniprot
P29597
canonical
ensembl
ENSG00000105397
resolver
ensp
ENSP00000431885
resolver
ensp
ENSP00000432320
resolver
ensp
ENSP00000433203
resolver
ensp
ENSP00000434831
resolver
ensp
ENSP00000436175
resolver
ensp
ENSP00000514328
resolver
ensp
ENSP00000514329
resolver
ensp
ENSP00000626033
resolver
ensp
ENSP00000626035
resolver
ensp
ENSP00000699146
resolver
ensp
ENSP00000699147
resolver
ensp
ENSP00000699148
resolver
ensp
ENSP00000699152
resolver
ensp
ENSP00000699158
resolver
enst
ENST00000525621
resolver
enst
ENST00000525976
resolver
enst
ENST00000531836
resolver
enst
ENST00000533334
resolver
enst
ENST00000699355
resolver
enst
ENST00000699358
resolver
enst
ENST00000955974
resolver
genesymbol
TYK2
resolver
hgnc
HGNC:12440
resolver
uniprot
A0A8V8TN50
resolver
uniprot
A0A8V8TPX5
resolver
uniprot
H0YCT7
resolver
uniprot
H0YE24
resolver
uniprot
Q6QB10
resolver
uniprot
Q96CH0
resolver
uniprot_entry
A0A8V8TN50_HUMAN
resolver
uniprot_entry
A0A8V8TPX5_HUMAN
resolver
uniprot_entry
H0YCT7_HUMAN
resolver
uniprot_entry
H0YE24_HUMAN
resolver
uniprot_entry
TYK2_HUMAN
resolver
uniprot_sec
Q6QB10
resolver
uniprot_sec
Q96CH0
resolver
activity_regulation
ACTIVITY REGULATION: The protein kinase 1 domain (also termed pseudokinase domain) mediates autoinhibition of the TYK2 kinase domain. {ECO:0000269|PubMed:24843152, ECO:0000269|PubMed:25762719}.
uniprot
proteins
amino_acid_sequence
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHIAHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREPAVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFKNESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRRFLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAPTDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHKAVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLVDGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHPYRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRAGDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTRTNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLAPECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQLATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHIIKYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYYASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKCPCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency 35 (IMD35) [MIM:611521]: A primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE. {ECO:0000269|PubMed:17088085}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.10.2
uniprot
proteins
function
FUNCTION: Non-membrane spanning protein tyrosine kinase involved in numerous cytokines and interferons signaling, which regulates cell growth, development, cell migration, innate and adaptive immunity (PubMed:10542297, PubMed:10995743, PubMed:7657660, PubMed:7813427, PubMed:8232552). Plays both structural and catalytic roles in numerous interleukins and interferons (IFN-alpha/beta) signaling (PubMed:10542297). Associates with heterodimeric cytokine receptor complexes and activates STAT family members including STAT1, STAT3, STAT4 or STAT6 (PubMed:10542297, PubMed:7638186). The heterodimeric cytokine receptor complexes are composed of (1) a TYK2-associated receptor chain (IFNAR1, IL12RB1, IL10RB or IL13RA1), and (2) a second receptor chain associated either with JAK1 or JAK2 (PubMed:10542297, PubMed:25762719, PubMed:7526154, PubMed:7813427). In response to cytokine-binding to receptors, phosphorylates and activates receptors (IFNAR1, IL12RB1, IL10RB or IL13RA1), creating docking sites for STAT members (PubMed:7526154, PubMed:7657660). In turn, recruited STATs are phosphorylated by TYK2 (or JAK1/JAK2 on the second receptor chain), form homo- and heterodimers, translocate to the nucleus, and regulate cytokine/growth factor responsive genes (PubMed:10542297, PubMed:25762719, PubMed:7657660). Negatively regulates STAT3 activity by promototing phosphorylation at a specific tyrosine that differs from the site used for signaling (PubMed:29162862). Involved in the oncostatin-M-mediated signaling pathway through both type I OSM receptor complex (heterodimers composed of LIFR and IL6ST) and type II OSM receptor complex (heterodimers composed of OSMR and IL6ST) (PubMed:9188471). {ECO:0000269|PubMed:10542297, ECO:0000269|PubMed:10995743, ECO:0000269|PubMed:25762719, ECO:0000269|PubMed:29162862, ECO:0000269|PubMed:7526154, ECO:0000269|PubMed:7638186, ECO:0000269|PubMed:7657660, ECO:0000269|PubMed:7813427, ECO:0000269|PubMed:8232552, ECO:0000269|PubMed:9188471}.
uniprot
proteins
mass_dalton
133650
uniprot
proteins
mutagenesis
MUTAGEN 930; /note="K->R: Complete loss of catalytic activity."; /evidence="ECO:0000269|PubMed:8702790"; MUTAGEN 1023; /note="D->N: Complete loss of catalytic activity."; /evidence="ECO:0000269|PubMed:24843152"; MUTAGEN 1054; /note="Y->F: Reduces basal catalytic activity and abolishes IFN-dependent activation."; /evidence="ECO:0000269|PubMed:8702790"; MUTAGEN 1055; /note="Y->F: Reduces basal catalytic activity and abolishes IFN-dependent activation."; /evidence="ECO:0000269|PubMed:8702790"; MUTAGEN 1145; /note="Y->F: Does not affect phosphorylation state and enzymatic activity."; /evidence="ECO:0000269|PubMed:8702790"; MUTAGEN 1176; /note="Y->F: Does not affect phosphorylation state and enzymatic activity."; /evidence="ECO:0000269|PubMed:8702790
uniprot
proteins
post_translational_modification
PTM: Phosphorylated (PubMed:7638186). Phosphorylation by JAK1 at Tyr-1054 and Tyr-1055 induces kinase activation (PubMed:8232552, PubMed:8702790). {ECO:0000269|PubMed:7638186, ECO:0000269|PubMed:8702790, ECO:0000305|PubMed:8232552}.
uniprot
proteins
protein_family
JAK subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
10523853
uniprot
proteins
pubmed
10542297
uniprot
proteins
pubmed
10995743
uniprot
proteins
pubmed
1386289
uniprot
proteins
pubmed
15277531
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15899890
uniprot
proteins
pubmed
16987978
uniprot
proteins
pubmed
17088085
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
20478313
uniprot
proteins
pubmed
2156206
uniprot
proteins
pubmed
2216457
uniprot
proteins
pubmed
2247464
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24843152
uniprot
proteins
pubmed
25762719
uniprot
proteins
pubmed
29162862
uniprot
proteins
pubmed
32213613
uniprot
proteins
pubmed
7526154
uniprot
proteins
pubmed
7638186
uniprot
proteins
pubmed
7657660
uniprot
proteins
pubmed
7813427
uniprot
proteins
pubmed
8232552
uniprot
proteins
pubmed
8702790
uniprot
proteins
pubmed
9188471
uniprot
proteins
sequence_length
1187
uniprot
proteins