HORMAD1
entrez
84072
canonical
uniprot
Q86X24
canonical
ensembl
ENSG00000143452
resolver
ensp
ENSP00000326489
resolver
ensp
ENSP00000355167
resolver
ensp
ENSP00000357991
resolver
ensp
ENSP00000765316
resolver
genesymbol
HORMAD1
resolver
genesymbol_syn
NOHMA
resolver
hgnc
HGNC:25245
resolver
uniprot
A0A140VKG9
resolver
uniprot
A6NMK2
resolver
uniprot
B3KUK1
resolver
uniprot
Q4G114
resolver
uniprot
Q5T5I3
resolver
uniprot
Q5T5I4
resolver
uniprot
Q5T5I5
resolver
uniprot
Q6FIC1
resolver
uniprot
Q9H0K8
resolver
uniprot_entry
A0A140VKG9_HUMAN
resolver
uniprot_entry
HORM1_HUMAN
resolver
uniprot_sec
A6NMK2
resolver
uniprot_sec
B3KUK1
resolver
uniprot_sec
Q4G114
resolver
uniprot_sec
Q5T5I3
resolver
uniprot_sec
Q5T5I4
resolver
uniprot_sec
Q5T5I5
resolver
uniprot_sec
Q6FIC1
resolver
uniprot_sec
Q9H0K8
resolver
amino_acid_sequence
MATAQLQRTPMSALVFPNKISTEHQSLVLVKRLLAVSVSCITYLRGIFPECAYGTRYLDDLCVKILREDKNCPGSTQLVKWMLGCYDALQKKYLRMVVLAVYTNPEDPQTISECYQFKFKYTNNGPLMDFISKNQSNESSMLSTDTKKASILLIRKIYILMQNLGPLPNDVCLTMKLFYYDEVTPPDYQPPGFKDGDCEGVIFEGEPMYLNVGEVSTPFHIFKVKVTTERERMENIDSTILSPKQIKTPFQKILRDKDVEDEQEHYTSDDLDIETKMEEQEKNPASSELEEPSLVCEEDEIMRSKESPDLSISHSQVEQLVNKTSELDMSESKTRSGKVFQNKMANGNQPVKSSKENRKRSQHESGRIVLHHFDSSSQESVPKRRKFSEPKEHI
uniprot
proteins
function
FUNCTION: Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes. {ECO:0000250|UniProtKB:Q9D5T7}.
uniprot
proteins
mass_dalton
45200
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-377 in a SPO11-dependent manner. {ECO:0000250|UniProtKB:Q9D5T7}.
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15567723
uniprot
proteins
pubmed
15999985
uniprot
proteins
pubmed
16710414
uniprot
proteins
sequence_length
394
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9D5T7}. Chromosome {ECO:0000250|UniProtKB:Q9D5T7}. Note=Preferentially localizes to unsynapsed or desynapsed chromosomal regions during the prophase I stage of meiosis. TRIP13 is required for depletion from synapsed chromosomes. The expression of the phosphorylated form at Ser-377 is restricted to unsynapsed chromosomal regions (By similarity). {ECO:0000250|UniProtKB:Q9D5T7}.
uniprot
proteins