Rnf185
entrez
360967
canonical
uniprot
Q568Y3
canonical
ensembl
ENSRNOG00000019325
resolver
ensembl
ENSRNOG00055027398
resolver
ensembl
ENSRNOG00060030902
resolver
ensembl
ENSRNOG00065029921
resolver
ensp
ENSRNOP00000026134
resolver
ensp
ENSRNOP00055039016
resolver
ensp
ENSRNOP00060044545
resolver
ensp
ENSRNOP00065042545
resolver
enst
ENSRNOT00000026134
resolver
enst
ENSRNOT00055047438
resolver
enst
ENSRNOT00060053663
resolver
enst
ENSRNOT00065051684
resolver
genesymbol
Rnf185
resolver
uniprot_entry
RN185_RAT
resolver
amino_acid_sequence
MASKGPSASASTENSSAGGPSGSSNGTGESGGQDSTFECNICLDTAKDAVISLCGHLFCWPCLHQWLETRPNRQVCPVCKAGISRDKVIPLYGRGSTGQQDPREKTPPRPQGQRPEPENRGGFQGFGFGDGGFQMSFGIGAFPFGIFATAFNINDGRPPPAVPGTPQYVDEQFLSRLFLFVALVIMFWLLIA
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that regulates selective mitochondrial autophagy by mediating 'Lys-63'-linked polyubiquitination of BNIP1. Acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis. Responsible for the cotranslational ubiquitination and degradation of CFTR in the ERAD pathway. Also acts as a regulator of the innate antiviral response by catalyzing 'Lys-27'-linked polyubiquitination of CGAS, thereby promoting CGAS cyclic GMP-AMP synthase activity. Preferentially associates with the E2 enzymes UBE2J1 and UBE2J2. {ECO:0000250|UniProtKB:Q96GF1}.
uniprot
proteins
mass_dalton
20493
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q96GF1}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
192
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q96GF1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96GF1}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q96GF1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96GF1}.
uniprot
proteins
transmembrane_region
TRANSMEM 131..151; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 172..192; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins