Pacs1
entrez
107975
canonical
uniprot
Q8K212
canonical
ensembl
ENSMUSG00000024855
resolver
ensp
ENSMUSP00000025786
resolver
ensp
ENSMUSP00000272238
resolver
ensp
ENSMUSP00000272239
resolver
ensp
ENSMUSP00000272240
resolver
ensp
ENSMUSP00000272241
resolver
enst
ENSMUST00000025786
resolver
genesymbol
Pacs1
resolver
uniprot
Q6P5H8
resolver
uniprot_entry
PACS1_MOUSE
resolver
uniprot_sec
Q6P5H8
resolver
amino_acid_sequence
MAERGGAGGGPGGSGGGSSQRGSGVAQSPQQQPQQQPPQPQQPTPPKLAQATSSSSSTSAAAASSSSSSTSTSMAVAVASGSAPPGGPGPGRTPAPVQMNLYATWEVDRSSSSCVPRLFSLTLKKLVMLKEMDKDLNSVVIAVKLQGSKRILRSNEIILPASGLVETELQLTFSLQYPHFLKRDANKLQIMLQRRKRYKNRTILGYKTLAVGLINMAEVMQHPNEGALVLGLHSNVKDVSVPVAEIKIYSLSSQPIDHEGIKSKLSDRSPDIDNYSEEEEESFSSEQEGSDDPLHGQDLFYEDEDLRKVKKTRRKLTSTSAITRQPNIKQKFVALLKRFKVSDEVGFGLEHVSREQIREVEEDLDELYDSLEMYNPSDSGPEMEETESILSTPKPKLKPFFEGMSQSSSQTEIGSLNSKGSLGKDTTSPMELAALEKVKSTWIKNQDDSLTETDTLEITDQDMFGDVSTSLVVPEKVKTPMKSSKADLQGSASPSKVEGTHTPRQKRSTPLKERQLSKPLSERTNSSDSERSPDLGHSTQIPRKVVYDQLNQILVSDAALPENVILVNTTDWQGQYVAELLQDQRKPVVCTCSTVEVQAVLSALLTRIQRYCNCNSSMPRPVKVAAVGSQSYLSSILRFFVKSLASKTPDWLGYMRFLIIPLGSHPVAKYLGSVDSRYSSTFLDSAWRDLFSRSEPPVSEPLDVVGRVMQYVNGATTTHQLPVAEAMLTCRHKFPDEDSYQKFIPFIGVVKVGLVEDSPSTAGDGDDSPVVSLTVPSTSPPSSSGLSRDATATPPSSPSMSSALAIVGSPNSPYGDVIGLQVDYWLGHPGERRREGDKRDASSKNTLKSVFRSVQVSRLPHAGEAQLSGTMAMTVVTKEKNKKVPTIFLSKKPREKEVDSKSQVIEGISRLICSAKQQQTMLRVSIDGVEWSDIKFFQLAAQWPTHVKHFPVGLFSGSKTT
uniprot
proteins
function
FUNCTION: Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits (By similarity). Required for normal ER Ca2+ handling in lymphocytes. Together with WDR37, it plays an essential role in lymphocyte development, quiescence and survival. Required for stabilizing peripheral lymphocyte populations (PubMed:33630350). {ECO:0000250|UniProtKB:O88588, ECO:0000250|UniProtKB:Q6VY07, ECO:0000269|PubMed:33630350}.
uniprot
proteins
mass_dalton
104829
uniprot
proteins
mutagenesis
MUTAGEN 102..961; /note="Missing: In mouse mutant endive (en); reduced proportion of B cells in peripheral blood."; /evidence="ECO:0000269|PubMed:33630350"; MUTAGEN 757; /note="D->G: In mouse mutant chicory (ccy); reduced proportion of B cells in peripheral blood."; /evidence="ECO:0000269|PubMed:33630350
uniprot
proteins
protein_family
PACS family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15692563
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
33630350
uniprot
proteins
pubmed
9695949
uniprot
proteins
sequence_length
961
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:O88588}. Note=Localizes in the perinuclear region, probably the TGN. {ECO:0000250|UniProtKB:O88588}.
uniprot
proteins