Acvr2a
entrez
11480
canonical
uniprot
P27038
canonical
ensembl
ENSMUSG00000052155
resolver
ensp
ENSMUSP00000067305
resolver
ensp
ENSMUSP00000285442
resolver
enst
ENSMUST00000063886
resolver
genesymbol
Acvr2a
resolver
genesymbol_syn
Acvr2
resolver
uniprot
A2AI38
resolver
uniprot
Q8BRV4
resolver
uniprot_entry
A2AI38_MOUSE
resolver
uniprot_entry
AVR2A_MOUSE
resolver
uniprot_entry
Q8BRV4_MOUSE
resolver
amino_acid_sequence
MGAAAKLAFAVFLISCSSGAILGRSETQECLFFNANWERDRTNQTGVEPCYGDKDKRRHCFATWKNISGSIEIVKQGCWLDDINCYDRTDCIEKKDSPEVYFCCCEGNMCNEKFSYFPEMEVTQPTSNPVTPKPPYYNILLYSLVPLMLIAGIVICAFWVYRHHKMAYPPVLVPTQDPGPPPPSPLLGLKPLQLLEVKARGRFGCVWKAQLLNEYVAVKIFPIQDKQSWQNEYEVYSLPGMKHENILQFIGAEKRGTSVDVDLWLITAFHEKGSLSDFLKANVVSWNELCHIAETMARGLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHGQVGTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFEEEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTNIITTEDIVTVVTMVTNVDFPPKESSL
uniprot
proteins
ec_number
2.7.11.30
uniprot
proteins
function
FUNCTION: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6 (PubMed:23527555). {ECO:0000269|PubMed:1646080, ECO:0000269|PubMed:23527555, ECO:0000269|PubMed:8395525}.
uniprot
proteins
mass_dalton
57890
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
TGFB receptor subfamily
uniprot
proteins
protein_family
TKL Ser/Thr protein kinase family
uniprot
proteins
pubmed
10449041
uniprot
proteins
pubmed
10681527
uniprot
proteins
pubmed
1646080
uniprot
proteins
pubmed
23527555
uniprot
proteins
pubmed
8395525
uniprot
proteins
pubmed
9886286
uniprot
proteins
sequence_length
513
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1646080}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 136..161; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins