AKAP3
entrez
10566
canonical
uniprot
O75969
canonical
ensembl
ENSG00000111254
resolver
ensp
ENSP00000228850
resolver
ensp
ENSP00000440994
resolver
ensp
ENSP00000531524
resolver
ensp
ENSP00000531525
resolver
ensp
ENSP00000531526
resolver
ensp
ENSP00000531527
resolver
ensp
ENSP00000531528
resolver
ensp
ENSP00000604787
resolver
ensp
ENSP00000604788
resolver
ensp
ENSP00000604789
resolver
ensp
ENSP00000611636
resolver
ensp
ENSP00000611637
resolver
enst
ENST00000228850
resolver
enst
ENST00000545990
resolver
enst
ENST00000861465
resolver
enst
ENST00000861466
resolver
enst
ENST00000861467
resolver
enst
ENST00000861468
resolver
enst
ENST00000861469
resolver
enst
ENST00000934728
resolver
enst
ENST00000934729
resolver
enst
ENST00000934730
resolver
enst
ENST00000941577
resolver
enst
ENST00000941578
resolver
genesymbol
AKAP3
resolver
genesymbol
HEL159
resolver
genesymbol_syn
AKAP110
resolver
genesymbol_syn
SOB1
resolver
hgnc
HGNC:373
resolver
uniprot
O75945
resolver
uniprot
Q86X01
resolver
uniprot
Q9UM61
resolver
uniprot
V9HWD4
resolver
uniprot_entry
AKAP3_HUMAN
resolver
uniprot_entry
V9HWD4_HUMAN
resolver
uniprot_sec
O75945
resolver
uniprot_sec
Q86X01
resolver
uniprot_sec
Q9UM61
resolver
amino_acid_sequence
MSEKVDWLQSQNGVCKVDVYSPGDNQAQDWKMDTSTDPVRVLSWLRRDLEKSTAEFQDVRFKPGESFGGETSNSGDPHKGFSVDYYNTTTKGTPERLHFEMTHKEIPCQGPRAQLGNGSSVDEVSFYANRLTNLVIAMARKEINEKIDGSENKCVYQSLYMGNEPTPTKSLSKIASELVNETVSACSRNAAPDKAPGSGDRVSGSSQSPPNLKYKSTLKIKESTKERQGPDDKPPSKKSFFYKEVFESRNGDYAREGGRFFPRERKRFRGQERPDDFTASVSEGIMTYANSVVSDMMVSIMKTLKIQVKDTTIATILLKKVLLKHAKEVVSDLIDSFLRNLHSVTGTLMTDTQFVSAVKRTVFSHGSQKATDIMDAMLRKLYNVMFAKKVPEHVRKAQDKAESYSLISMKGMGDPKNRNVNFAMKSETKLREKMYSEPKSEEETCAKTLGEHIIKEGLTLWHKTQQKECKSLGFQHAAFEAPNTQRKPASDISFEYPEDIGNLSLPPYPPEKPENFMYDSDSWAEDLIVSALLLIQYHLAQGGRRDARSFVEAAGTTNFPANEPPVAPDESCLKSAPIVGDQEQAEKKDLRSVFFNFIRNLLSETIFKRDQSPEPKVPEQPVKEDRKLCERPLASSPPRLYEDDETPGALSGLTKMAVSQIDGHMSGQMVEHLMNSVMKLCVIIAKSCDASLAELGDDKSGDASRLTSAFPDSLYECLPAKGTGSAEAVLQNAYQAIHNEMRGTSGQPPEGCAAPTVIVSNHNLTDTVQNKQLQAVLQWVAASELNVPILYFAGDDEGIQEKLLQLSAAAVDKGCSVGEVLQSVLRYEKERQLNEAVGNVTPLQLLDWLMVNL
uniprot
proteins
disease_involvement
DISEASE: Spermatogenic failure 82 (SPGF82) [MIM:620353]: An autosomal recessive male infertility disorder characterized by asthenoteratozoospermia and multiple morphologic abnormalities of the sperm flagella. {ECO:0000269|PubMed:35228300}. Note=The disease may be caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Structural component of sperm fibrous sheath (By similarity). Required for the formation of the subcellular structure of the sperm flagellum, sperm motility and male fertility (PubMed:35228300). {ECO:0000250|UniProtKB:O88987, ECO:0000269|PubMed:35228300}.
uniprot
proteins
mass_dalton
94751
uniprot
proteins
mutagenesis
MUTAGEN 131; /note="L->P: Abolishes interaction with ROPN1."; /evidence="ECO:0000269|PubMed:11278869
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by STK33 during sperm flagella assembly (By similarity). Phosphorylated on tyrosine residues (PubMed:10529264). {ECO:0000250|UniProtKB:O88987, ECO:0000269|PubMed:10529264}.
uniprot
proteins
protein_family
AKAP110 family
uniprot
proteins
pubmed
10319321
uniprot
proteins
pubmed
10334916
uniprot
proteins
pubmed
10529264
uniprot
proteins
pubmed
11278869
uniprot
proteins
pubmed
12509440
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
30683861
uniprot
proteins
pubmed
35228300
uniprot
proteins
sequence_length
853
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:O88987}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:O88987}. Note=Dorsal margin of the acrosomal segment. Ribs of the fibrous sheath in the principal piece of the sperm tail. {ECO:0000250|UniProtKB:O88987}.
uniprot
proteins