Lgi1
entrez
252892
canonical
uniprot
Q8K4Y5
canonical
ensembl
ENSRNOG00000014758
resolver
ensembl
ENSRNOG00055028207
resolver
ensembl
ENSRNOG00060029382
resolver
ensembl
ENSRNOG00065028674
resolver
ensp
ENSRNOP00000078389
resolver
ensp
ENSRNOP00055040110
resolver
ensp
ENSRNOP00060042451
resolver
ensp
ENSRNOP00065040574
resolver
enst
ENSRNOT00000113976
resolver
enst
ENSRNOT00055048799
resolver
enst
ENSRNOT00060051027
resolver
enst
ENSRNOT00065049450
resolver
genesymbol
Lgi1
resolver
uniprot
Q5FWS7
resolver
uniprot_entry
LGI1_RAT
resolver
uniprot_sec
Q5FWS7
resolver
amino_acid_sequence
MESESIRRMGNACIPLKRIAYFLCLFSVVLLTEGKKPAKPKCPAVCTCSKDNALCENARSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDDAFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNSFNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSPKDFDCIITEFAKSQDLPYQSLSIDTFSYLNDEYVVIAQPFTGKCIFLEWDHVEKTFRNYDNITGTSTVVCKPIVIDTQLYVIVAQLFGGSHIYKRDGFANKFIKIQDIEVLKIRKPNDIETFKIEDNWYFVVADSSKAGFTTIYKWNGNGFYSHQSLHAWYRDTDVEYLEIARPPLTLRTPHLILSSSSQRPVIYQWSKATQLFINQTDIPNMEDVYAVKHFSVKGDVYICLTRFIGDSKVMKWGGSSFQDIQRMPSRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAKFVKFQELNVQAPRSFTHVSINKRNFLFASSFKGNTQIYKHVIVDLSA
uniprot
proteins
function
FUNCTION: Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway (By similarity). {ECO:0000250|UniProtKB:O95970, ECO:0000269|PubMed:16504945, ECO:0000269|PubMed:16990550}.
uniprot
proteins
mass_dalton
63728
uniprot
proteins
mutagenesis
MUTAGEN 383; /note="E->A: Fails to bind to ADAM22."; /evidence="ECO:0000269|PubMed:16990550
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:O95970}.
uniprot
proteins
pubmed
12217514
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16504945
uniprot
proteins
pubmed
16990550
uniprot
proteins
sequence_length
557
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16990550}. Synapse {ECO:0000269|PubMed:16504945}. Cytoplasm {ECO:0000250|UniProtKB:Q9JIA1}.
uniprot
proteins