MASTL
entrez
84930
canonical
uniprot
Q96GX5
canonical
ensembl
ENSG00000120539
resolver
ensp
ENSP00000343446
resolver
ensp
ENSP00000365107
resolver
ensp
ENSP00000365113
resolver
ensp
ENSP00000566873
resolver
ensp
ENSP00000566874
resolver
ensp
ENSP00000604000
resolver
ensp
ENSP00000604001
resolver
ensp
ENSP00000639710
resolver
ensp
ENSP00000639712
resolver
genesymbol
MASTL
resolver
genesymbol_syn
GW
resolver
genesymbol_syn
GWL
resolver
genesymbol_syn
THC2
resolver
hgnc
HGNC:19042
resolver
uniprot
Q5T8D5
resolver
uniprot
Q5T8D7
resolver
uniprot
Q8NCD6
resolver
uniprot
Q96SJ5
resolver
uniprot_entry
GWL_HUMAN
resolver
uniprot_sec
Q5T8D5
resolver
uniprot_sec
Q5T8D7
resolver
uniprot_sec
Q8NCD6
resolver
uniprot_sec
Q96SJ5
resolver
amino_acid_sequence
MDPTAGSKKEPGGGAATEEGVNRIAVPKPPSIEEFSIVKPISRGAFGKVYLGQKGGKLYAVKVVKKADMINKNMTHQVQAERDALALSKSPFIVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVTLNRDINMMDILTTPSMAKPRQDYSRTPGQVLSLISSLGFNTPIAEKNQDPANILSACLSETSQLSQGLVCPMSVDQKDTTPYSSKLLKSCLETVASNPGMPVKCLTSNLLQSRKRLATSSASSQSHTFISSVESECHSSPKWEKDCQESDEALGPTMMSWNAVEKLCAKSANAIETKGFNKKDLELALSPIHNSSALPTTGRSCVNLAKKCFSGEVSWEAVELDVNNINMDTDTSQLGFHQSNQWAVDSGGISEEHLGKRSLKRNFELVDSSPCKKIIQNKKTCVEYKHNEMTNCYTNQNTGLTVEVQDLKLSVHKSQQNDCANKENIVNSFTDKQQTPEKLPIPMIAKNLMCELDEDCEKNSKRDYLSSSFLCSDDDRASKNISMNSDSSFPGISIMESPLESQPLDSDRSIKESSFEESNIEDPLIVTPDCQEKTSPKGVENPAVQESNQKMLGPPLEVLKTLASKRNAVAFRSFNSHINASNNSEPSRMNMTSLDAMDISCAYSGSYPMAITPTQKRRSCMPHQQTPNQIKSGTPYRTPKSVRRGVAPVDDGRILGTPDYLAPELLLGRAHGPAVDWWALGVCLFEFLTGIPPFNDETPQQVFQNILKRDIPWPEGEEKLSDNAQSAVEILLTIDDTKRAGMKELKRHPLFSDVDWENLQHQTMPFIPQPDDETDTSYFEARNTAQHLTVSGFSL
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in MASTL may play a role in the pathogenesis of thrombocytopenia, a disorder defined by reduced number of platelets in circulating blood, resulting in the potential for increased bleeding and decreased ability for clotting. {ECO:0000269|PubMed:12890928}.
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance (PubMed:19680222). Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively (PubMed:38123684). ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high (PubMed:20818157). Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation. {ECO:0000269|PubMed:12890928, ECO:0000269|PubMed:19680222, ECO:0000269|PubMed:19793917, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157, ECO:0000269|PubMed:38123684}.
uniprot
proteins
mass_dalton
97319
uniprot
proteins
mutagenesis
MUTAGEN 72; /note="K->M: Hyperactive form."; /evidence="ECO:0000269|PubMed:21164014
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-741 by CDK1 during M phase activates its kinase activity (By similarity). Maximum phosphorylation occurs in prometaphase. {ECO:0000250, ECO:0000269|PubMed:20538976, ECO:0000269|PubMed:20818157}.
uniprot
proteins
protein_family
AGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
12890928
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19460416
uniprot
proteins
pubmed
19680222
uniprot
proteins
pubmed
19793917
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20538976
uniprot
proteins
pubmed
20818157
uniprot
proteins
pubmed
21164014
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
38123684
uniprot
proteins
sequence_length
879
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20818157}. Nucleus {ECO:0000269|PubMed:19460416, ECO:0000269|PubMed:20818157}. Cleavage furrow {ECO:0000269|PubMed:20818157}. Note=During interphase is mainly nuclear, upon nuclear envelope breakdown localizes at the cytoplasm and during mitosis at the centrosomes. Upon mitotic exit moves to the cleavage furrow. {ECO:0000269|PubMed:20818157}.
uniprot
proteins