Frey1
entrez
75641
canonical
uniprot
Q8CF31
canonical
ensembl
ENSMUSG00000044916
resolver
ensp
ENSMUSP00000051464
resolver
enst
ENSMUST00000054316
resolver
genesymbol
Frey1
resolver
genesymbol_syn
Frey
resolver
uniprot
A2AHH2
resolver
uniprot_entry
FREY_MOUSE
resolver
uniprot_sec
A2AHH2
resolver
amino_acid_sequence
MVLAMLGALYPRAGLSLFLFYLILAGALLRPQPQRSQQSVPEEFSAPLELLQPLSGLVDDYGLRPKHPRPGGPRPLLSQAQQRKRDGPNMADYYYDVNL
uniprot
proteins
function
FUNCTION: Key regulator for male fertility expressed transiently in round spermatids where it recruits IZUMO1 at the endoplasmic reticulum (ER) membrane and coordinates the oolemmal binding multimeric complex (IZUMO1 complex) assembly. Upon complete assembly of the IZUMO1 complex, its ER retention is released, facilitating IZUMO1 complex export to the acrosome (PubMed:35960805, PubMed:36050562). Through the interaction with SPPL2C, inhibits its intramembrane protease activity directly accessing the catalytic center of an I-CLiP (PubMed:35960805). {ECO:0000269|PubMed:35960805, ECO:0000269|PubMed:36050562}.
uniprot
proteins
mass_dalton
11064
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
35960805
uniprot
proteins
pubmed
36050562
uniprot
proteins
sequence_length
99
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:35960805}; Single-pass type II membrane protein {ECO:0000269|PubMed:35960805, ECO:0000269|PubMed:36050562}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..29; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins