Crb3
entrez
224912
canonical
uniprot
Q8QZT4
canonical
ensembl
ENSMUSG00000044279
resolver
ensp
ENSMUSP00000071729
resolver
ensp
ENSMUSP00000094902
resolver
ensp
ENSMUSP00000125760
resolver
ensp
ENSMUSP00000295838
resolver
genesymbol
Crb3
resolver
uniprot
Q3TJV6
resolver
uniprot_entry
CRUM3_MOUSE
resolver
uniprot_sec
Q3TJV6
resolver
amino_acid_sequence
MATPGLGVLLAFGLPMLPSGWSLTAPDPFTNSTTQPPGDESNGGLSSGAIVAITVVFSILGVLLIAVGLFLLMRKLREKRQTEGTYRPSSEEQVGARAPPPPNLKLPPEERLI
uniprot
proteins
function
FUNCTION: Involved in the establishment of cell polarity in mammalian epithelial cells (By similarity). Regulates the morphogenesis of tight junctions (PubMed:21145499). Involved in promoting phosphorylation and cytoplasmic retention of transcriptional coactivators YAP1 and WWTR1/TAZ which leads to suppression of TGFB1-dependent transcription of target genes such as CCN2/CTGF, SERPINE1/PAI1, SNAI1/SNAIL1 and SMAD7 (PubMed:21145499). {ECO:0000250|UniProtKB:Q9BUF7, ECO:0000269|PubMed:21145499}.
uniprot
proteins
mass_dalton
11921
uniprot
proteins
pubmed
12527193
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17920587
uniprot
proteins
pubmed
21145499
uniprot
proteins
pubmed
26404741
uniprot
proteins
sequence_length
113
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q9BUF7}; Single-pass type I membrane protein {ECO:0000255}. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9BUF7}. Note=Localizes primarily to the apical membrane with a small fraction in the upper part of tight junctions of epithelial cells. {ECO:0000250|UniProtKB:Q9BUF7}.
uniprot
proteins
transmembrane_region
TRANSMEM 50..70; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins