ERCC6L
entrez
54821
canonical
uniprot
Q2NKX8
canonical
ensembl
ENSG00000186871
resolver
ensp
ENSP00000334675
resolver
ensp
ENSP00000362761
resolver
enst
ENST00000334463
resolver
enst
ENST00000373657
resolver
genesymbol
ERCC6L
resolver
genesymbol_syn
PICH
resolver
hgnc
HGNC:20794
resolver
uniprot
B5MDQ0
resolver
uniprot
Q8NCI1
resolver
uniprot
Q96H93
resolver
uniprot
Q9NXQ8
resolver
uniprot_entry
B5MDQ0_HUMAN
resolver
uniprot_entry
ERC6L_HUMAN
resolver
uniprot_sec
Q8NCI1
resolver
uniprot_sec
Q96H93
resolver
uniprot_sec
Q9NXQ8
resolver
amino_acid_sequence
MEASRRFPEAEALSPEQAAHYLRYVKEAKEATKNGDLEEAFKLFNLAKDIFPNEKVLSRIQKIQEALEELAEQGDDEFTDVCNSGLLLYRELHNQLFEHQKEGIAFLYSLYRDGRKGGILADDMGLGKTVQIIAFLSGMFDASLVNHVLLIMPTNLINTWVKEFIKWTPGMRVKTFHGPSKDERTRNLNRIQQRNGVIITTYQMLINNWQQLSSFRGQEFVWDYVILDEAHKIKTSSTKSAICARAIPASNRLLLTGTPIQNNLQELWSLFDFACQGSLLGTLKTFKMEYENPITRAREKDATPGEKALGFKISENLMAIIKPYFLRRTKEDVQKKKSSNPEARLNEKNPDVDAICEMPSLSRKNDLIIWIRLVPLQEEIYRKFVSLDHIKELLMETRSPLAELGVLKKLCDHPRLLSARACCLLNLGTFSAQDGNEGEDSPDVDHIDQVTDDTLMEESGKMIFLMDLLKRLRDEGHQTLVFSQSRQILNIIERLLKNRHFKTLRIDGTVTHLLEREKRINLFQQNKDYSVFLLTTQVGGVGLTLTAATRVVIFDPSWNPATDAQAVDRVYRIGQKENVVVYRLITCGTVEEKIYRRQVFKDSLIRQTTGEKKNPFRYFSKQELRELFTIEDLQNSVTQLQLQSLHAAQRKSDIKLDEHIAYLQSLGIAGISDHDLMYTCDLSVKEELDVVEESHYIQQRVQKAQFLVEFESQNKEFLMEQQRTRNEGAWLREPVFPSSTKKKCPKLNKPQPQPSPLLSTHHTQEEDISSKMASVVIDDLPKEGEKQDLSSIKVNVTTLQDGKGTGSADSIATLPKGFGSVEELCTNSSLGMEKSFATKNEAVQKETLQEGPKQEALQEDPLESFNYVLSKSTKADIGPNLDQLKDDEILRHCNPWPIISITNESQNAESNVSIIEIADDLSASHSALQDAQASEAKLEEEPSASSPQYACDFNLFLEDSADNRQNFSSQSLEHVEKENSLCGSAPNSRAGFVHSKTCLSWEFSEKDDEPEEVVVKAKIRSKARRIVSDGEDEDDSFKDTSSINPFNTSLFQFSSVKQFDASTPKNDISPPGRFFSSQIPSSVNKSMNSRRSLASRRSLINMVLDHVEDMEERLDDSSEAKGPEDYPEEGVEESSGEASKYTEEDPSGETLSSENKSSWLMTSKPSALAQETSLGAPEPLSGEQLVGSPQDKAAEATNDYETLVKRGKELKECGKIQEALNCLVKALDIKSADPEVMLLTLSLYKQLNNN
uniprot
proteins
ec_number
3.6.4.12
uniprot
proteins
function
FUNCTION: DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase (PubMed:17218258, PubMed:23973328). Functions as ATP-dependent DNA translocase (PubMed:23973328, PubMed:28977671). Can promote Holliday junction branch migration (in vitro) (PubMed:23973328). {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:23973328, ECO:0000269|PubMed:28977671}.
uniprot
proteins
mass_dalton
141103
uniprot
proteins
mutagenesis
MUTAGEN 11; /note="E->A: Decreased affinity for BEND3, and abolishes BEND3-mediated stimulation of ATPase activity; when associated with A-13 and A-21."; /evidence="ECO:0000269|PubMed:28977671"; MUTAGEN 13; /note="L->A: Decreased affinity for BEND3, and abolishes BEND3-mediated stimulation of ATPase activity; when associated with A-11 and A-21."; /evidence="ECO:0000269|PubMed:28977671"; MUTAGEN 21; /note="Y->A: Decreased affinity for BEND3, and abolishes BEND3-mediated stimulation of ATPase activity; when associated with A-11 and A-13."; /evidence="ECO:0000269|PubMed:28977671"; MUTAGEN 127..129; /note="GKT->AAA: Abolishes chromatin association."; /evidence="ECO:0000269|PubMed:17218258"; MUTAGEN 128; /note="K->A: Abolishes ATPase activity."; /evidence="ECO:0000269|PubMed:23973328"; MUTAGEN 1063; /note="T->A: Induces a decrease in phosphorylation."; /evidence="ECO:0000269|PubMed:17218258
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by PLK1 prevents the association with chromosome arms and restricts its localization to the kinetochore-centromere region. {ECO:0000269|PubMed:17218258}.
uniprot
proteins
protein_family
SNF2/RAD54 helicase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17218258
uniprot
proteins
pubmed
17599064
uniprot
proteins
pubmed
17671160
uniprot
proteins
pubmed
17956945
uniprot
proteins
pubmed
17989990
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19904549
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23973328
uniprot
proteins
pubmed
28977671
uniprot
proteins
sequence_length
1250
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome, centromere {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:17989990}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:17218258}. Chromosome {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:17671160, ECO:0000269|PubMed:17989990}. Note=Localizes to kinetochores, inner centromeres and thin threads connecting separating chromosomes even during anaphase. In prometaphase cells, it mostly concentrates in between kinetochores. In metaphase, it localizes to numerous thin threads that stretch between sister kinetochores of the aligned chromosomes and are composed of catenated centromeric DNA. Evolution from inner centromeres to thin threads takes place in response to tension. Resolution of thin threads requires topoisomerase 2-alpha (TOP2A) after anaphase onset. {ECO:0000269|PubMed:17218258, ECO:0000269|PubMed:17671160, ECO:0000269|PubMed:17956945, ECO:0000269|PubMed:17989990}.
uniprot
proteins