HGFAC
entrez
3083
canonical
uniprot
Q04756
canonical
ensembl
ENSG00000109758
resolver
ensp
ENSP00000372224
resolver
ensp
ENSP00000421801
resolver
enst
ENST00000382774
resolver
enst
ENST00000511533
resolver
genesymbol
HGFAC
resolver
hgnc
HGNC:4894
resolver
uniprot
D6RAR4
resolver
uniprot
Q14726
resolver
uniprot
Q2M1W7
resolver
uniprot
Q53X47
resolver
uniprot_entry
D6RAR4_HUMAN
resolver
uniprot_entry
HGFA_HUMAN
resolver
uniprot_sec
Q14726
resolver
uniprot_sec
Q2M1W7
resolver
uniprot_sec
Q53X47
resolver
amino_acid_sequence
MGRWAWVPSPWPPPGLGPFLLLLLLLLLLPRGFQPQPGGNRTESPEPNATATPAIPTILVTSVTSETPATSAPEAEGPQSGGLPPPPRAVPSSSSPQAQALTEDGRPCRFPFRYGGRMLHACTSEGSAHRKWCATTHNYDRDRAWGYCVEATPPPGGPAALDPCASGPCLNGGSCSNTQDPQSYHCSCPRAFTGKDCGTEKCFDETRYEYLEGGDRWARVRQGHVEQCECFGGRTWCEGTRHTACLSSPCLNGGTCHLIVATGTTVCACPPGFAGRLCNIEPDERCFLGNGTGYRGVASTSASGLSCLAWNSDLLYQELHVDSVGAAALLGLGPHAYCRNPDNDERPWCYVVKDSALSWEYCRLEACESLTRVQLSPDLLATLPEPASPGRQACGRRHKKRTFLRPRIIGGSSSLPGSHPWLAAIYIGDSFCAGSLVHTCWVVSAAHCFSHSPPRDSVSVVLGQHFFNRTTDVTQTFGIEKYIPYTLYSVFNPSDHDLVLIRLKKKGDRCATRSQFVQPICLPEPGSTFPAGHKCQIAGWGHLDENVSGYSSSLREALVPLVADHKCSSPEVYGADISPNMLCAGYFDCKSDACQGDSGGPLACEKNGVAYLYGIISWGDGCGRLHKPGVYTRVANYVDWINDRIRPPRRLVAPS
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Serine protease that hydrolyzes the inactive zymogen hepatocyte growth factor (HGFsc) to an activated disulfide-linked heterodimer, then initiating hepatocyte growth factor receptor signaling pathway. {ECO:0000269|PubMed:8226803}.
uniprot
proteins
mass_dalton
70682
uniprot
proteins
post_translational_modification
PTM: The active form of HGFAC presents in the serum is derived from the COOH-terminal region of the precursor by the cleavage of bonds between Arg-372 and Val-373 and Arg-407 and Ile-408. {ECO:0000269|PubMed:7683665, ECO:0000269|PubMed:8226803}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15713485
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
18077410
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
7683665
uniprot
proteins
pubmed
8226803
uniprot
proteins
pubmed
9874200
uniprot
proteins
sequence_length
655
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7683665, ECO:0000269|PubMed:8226803}. Note=Exists as an inactive zymogen in plasma (PubMed:8226803). Exists as an active heterodimeric form in serum (PubMed:7683665). {ECO:0000269|PubMed:7683665, ECO:0000269|PubMed:8226803}.
uniprot
proteins