BEX2
entrez
84707
canonical
uniprot
Q9BXY8
canonical
ensembl
ENSG00000133134
resolver
ensp
ENSP00000361759
resolver
ensp
ENSP00000361762
resolver
ensp
ENSP00000442521
resolver
genesymbol
BEX2
resolver
hgnc
HGNC:30933
resolver
uniprot
B2R574
resolver
uniprot
D3DXA2
resolver
uniprot
F5H7H5
resolver
uniprot
Q5JVV9
resolver
uniprot_entry
BEX2_HUMAN
resolver
uniprot_sec
B2R574
resolver
uniprot_sec
D3DXA2
resolver
uniprot_sec
F5H7H5
resolver
uniprot_sec
Q5JVV9
resolver
amino_acid_sequence
MESKEERALNNLIVENVNQENDEKDEKEQVANKGEPLALPLNVSEYCVPRGNRRRFRVRQPILQYRWDIMHRLGEPQARMREENMERIGEEVRQLMEKLREKQLSHSLRAVSTDPPHHDHHDEFCLMP
uniprot
proteins
function
FUNCTION: Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer (PubMed:19711341). Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA (PubMed:19711341). Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A (PubMed:19711341). Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity (PubMed:19711341). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity). {ECO:0000250|UniProtKB:Q9WTZ8, ECO:0000269|PubMed:19711341}.
uniprot
proteins
mass_dalton
15321
uniprot
proteins
protein_family
BEX family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
15958283
uniprot
proteins
pubmed
16314316
uniprot
proteins
pubmed
19711341
uniprot
proteins
sequence_length
128
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q3MKQ1}. Nucleus {ECO:0000269|PubMed:16314316}.
uniprot
proteins