IKZF4
entrez
64375
canonical
uniprot
Q9H2S9
canonical
ensembl
ENSG00000123411
resolver
ensp
ENSP00000262032
resolver
ensp
ENSP00000448419
resolver
ensp
ENSP00000450020
resolver
enst
ENST00000547791
resolver
genesymbol
IKZF4
resolver
genesymbol_syn
KIAA1782
resolver
genesymbol_syn
ZNFN1A4
resolver
hgnc
HGNC:13179
resolver
uniprot
F8VPL6
resolver
uniprot
Q96JP3
resolver
uniprot_entry
F8VPL6_HUMAN
resolver
uniprot_entry
IKZF4_HUMAN
resolver
uniprot_sec
Q96JP3
resolver
amino_acid_sequence
MHTPPALPRRFQGGGRVRTPGSHRQGKDNLERDPSGGCVPDFLPQAQDSNHFIMESLFCESSGDSSLEKEFLGAPVGPSVSTPNSQHSSPSRSLSANSIKVEMYSDEESSRLLGPDERLLEKDDSVIVEDSLSEPLGYCDGSGPEPHSPGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRSHTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCNYACRRRDALTGHLRTHSVSSPTVGKPYKCNYCGRSYKQQSTLEEHKERCHNYLQSLSTEAQALAGQPGDEIRDLEMVPDSMLHSSSERPTFIDRLANSLTKRKRSTPQKFVGEKQMRFSLSDLPYDVNSGGYEKDVELVAHHSLEPGFGSSLAFVGAEHLRPLRLPPTNCISELTPVISSVYTQMQPLPGRLELPGSREAGEGPEDLADGGPLLYRPRGPLTDPGASPSNGCQDSTDTESNHEDRVAGVVSLPQGPPPQPPPTIVVGRHSPAYAKEDPKPQEGLLRGTPGPSKEVLRVVGESGEPVKAFKCEHCRILFLDHVMFTIHMGCHGFRDPFECNICGYHSQDRYEFSSHIVRGEHKVG
uniprot
proteins
function
FUNCTION: DNA-binding protein that binds to the 5'GGGAATRCC-3' Ikaros-binding sequence. Transcriptional repressor. Interacts with SPI1 and MITF to repress transcription of the CTSK and ACP5 promoters via recruitment of corepressors SIN3A and CTBP2. May be involved in the development of central and peripheral nervous systems. Essential for the inhibitory function of regulatory T-cells (Treg). Mediates FOXP3-mediated gene silencing in regulatory T-cells (Treg) via recruitment of corepressor CTBP1 (By similarity). {ECO:0000250|UniProtKB:Q8C208, ECO:0000269|PubMed:10978333, ECO:0000269|PubMed:12015313, ECO:0000269|PubMed:12444977}.
uniprot
proteins
mass_dalton
64106
uniprot
proteins
mutagenesis
MUTAGEN 425..427; /note="PED->AAA: No effect on CTBP2 interaction."; /evidence="ECO:0000269|PubMed:12444977
uniprot
proteins
protein_family
Ikaros C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
10978333
uniprot
proteins
pubmed
11347906
uniprot
proteins
pubmed
12015313
uniprot
proteins
pubmed
12444977
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
585
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12444977}.
uniprot
proteins