Camlg
entrez
12328
canonical
uniprot
P49070
canonical
ensembl
ENSMUSG00000021501
resolver
ensp
ENSMUSP00000021963
resolver
enst
ENSMUST00000021963
resolver
genesymbol
Camlg
resolver
genesymbol_syn
Caml
resolver
genesymbol_syn
Get2
resolver
uniprot
Q99JU5
resolver
uniprot_entry
CAMLG_MOUSE
resolver
uniprot_sec
Q99JU5
resolver
amino_acid_sequence
MEPVPAATDGGERPATPSGLSASQRRAELRRRKLLMNSEQRINRIMGFHRPGSGSEEENQTKSKPQDSDKLNSLSIPSVSKRVVLGDSVDGGGADQLGGVAEVRGTQLGDKLDSFIKAPECSSKDGAELRQRTRGDLTADPAQRASHHGLEQYLSRFEEAMKLRKQLISEKPSQEDGSTAEEFDSFRIFRLVGCALLALGVRAFVCKYLSIFAPFLTLQLAYMGLYKYFPKGEKKVKTTVLTAALLLSGIPAEVINRSMDTYSKMGEVFTDLCVYFFTFIFCHELLDYWGPEVP
uniprot
proteins
function
FUNCTION: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (By similarity). Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (By similarity). Required for the stability of GET1 (By similarity). Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium (By similarity). Essential for the survival of peripheral follicular B cells (PubMed:22351938). {ECO:0000250|UniProtKB:P49069, ECO:0000269|PubMed:22351938}.
uniprot
proteins
mass_dalton
32542
uniprot
proteins
mutagenesis
MUTAGEN 202; /note="R->A: Impaired tail-anchored protein insertion and a shift from GET1-CAMLG heterotetramerization to formation of heterodimers but does not affect recruitment of GET3 to the endoplasmic reticulum; when associated with A-207."; /evidence="ECO:0000269|PubMed:32910895"; MUTAGEN 207; /note="K->A: Impaired tail-anchored protein insertion and a shift from GET1-CAMLG heterotetramerization to formation of heterodimers but does not affect recruitment of GET3 to the endoplasmic reticulum; when associated with A-202."; /evidence="ECO:0000269|PubMed:32910895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22351938
uniprot
proteins
pubmed
32910895
uniprot
proteins
pubmed
7590290
uniprot
proteins
sequence_length
294
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P49069}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 188..205; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 211..229; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 268..286; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins