TMEM196
entrez
256130
canonical
uniprot
Q5HYL7
canonical
ensembl
ENSG00000173452
resolver
ensp
ENSP00000384234
resolver
ensp
ENSP00000385087
resolver
ensp
ENSP00000414247
resolver
ensp
ENSP00000438368
resolver
ensp
ENSP00000786976
resolver
ensp
ENSP00000797632
resolver
enst
ENST00000405844
resolver
enst
ENST00000422233
resolver
genesymbol
TMEM196
resolver
hgnc
HGNC:22431
resolver
uniprot
B7WNR7
resolver
uniprot
F8WE15
resolver
uniprot
Q8N6I6
resolver
uniprot_entry
B7WNR7_HUMAN
resolver
uniprot_entry
F8WE15_HUMAN
resolver
uniprot_entry
TM196_HUMAN
resolver
uniprot_sec
Q8N6I6
resolver
amino_acid_sequence
MCTSGQIIGSLLVLSVLEIGLGVSSVAVGAVSFSLALREHKPQLGDSSPVWSGVCFLLCGICGILCAKKKSGLVMILFSACCICGLIGGILNFQFLRAVTKKTSSLYPLHLASMSLACIGIGGCTLSSWLTCRLASYEQRRMFSEREHSLHHSHEMAEKEITDNMSNGGPQLIFNGRV
uniprot
proteins
function
FUNCTION: Acts as a tumor suppressor in lung cancer (PubMed:26056045, PubMed:36355209). Inhibits tumor cell growth by inhibiting cell proliferation and migration and promoting cell apoptosis (PubMed:26056045, PubMed:36355209). Inhibits metastasis of lung cancer by suppressing beta-catenin expression in the Wnt/beta-catenin signaling pathway (By similarity). {ECO:0000250|UniProtKB:D3YWQ9, ECO:0000269|PubMed:26056045, ECO:0000269|PubMed:36355209}.
uniprot
proteins
mass_dalton
19025
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
26056045
uniprot
proteins
pubmed
36355209
uniprot
proteins
sequence_length
178
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:36355209}. Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Note=Expressed in the cytoplasm in lung cancer cells. {ECO:0000269|PubMed:36355209}.
uniprot
proteins
transmembrane_region
TRANSMEM 11..31; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 47..67; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 73..93; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 106..126; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins