Scaf8
entrez
245926
canonical
uniprot
Q63623
canonical
ensembl
ENSRNOG00000016919
resolver
ensp
ENSRNOP00000062541
resolver
ensp
ENSRNOP00000073484
resolver
ensp
ENSRNOP00000078015
resolver
enst
ENSRNOT00000065733
resolver
enst
ENSRNOT00000083425
resolver
enst
ENSRNOT00000109313
resolver
genesymbol
Scaf8
resolver
genesymbol_syn
Rbm16
resolver
uniprot
A0A0G2K5M7
resolver
uniprot
A0A8I5XWQ5
resolver
uniprot
F1LPT8
resolver
uniprot_entry
A0A0G2K5M7_RAT
resolver
uniprot_entry
A0A8I5XWQ5_RAT
resolver
uniprot_entry
F1LPT8_RAT
resolver
uniprot_entry
SCAF8_RAT
resolver
amino_acid_sequence
MEAVKTFNSELYSLNDYKPPISKAKMTQITKAAIKAIKFYKHVVQSVEKFIQKCKPEYKVPGLYVIDSIVRQSRHQVGQEKDVCAPRFSNNIISTFQNLYRCPGDDKSKIVRVLNLWQKNNVFKSEIIQPLLDMAAGIPPPVVTPVLASTTVAMSNTPGTPVTPVTPANVVQGLPDPWVSQITNTDTLAAVAQILQSPQGQQLQQLIQTLQIQQQKPQPSILQALDAGLVVQLQALTAQLTAAAAAANTLTPLDQGVSFNKKLMDRFDFGEDSEHSEESKKEIPTPQLSHVSESVNNSIFHQIAEQLQQQNLEQLRQQLLEQQQPQKVTPQDSQEGAFGSEHSASPSQGSSQQHFLEPEANLDDSIDIQQQDMDIDEGQDVVEEEIFEPEAKKVAVRSRSRTHSRSRSRSPRKRRSRSRSGSRKRKHRKRSRSRSRERKRKSSRSYSSERRAREREKERQKKGLPPVRSKTLSVCSTTLWVGQVDKKATQQDLTNLFEEFGQIESINMIPPRGCAYVCMVHRQDSFRALQKLSSGSYKIGSKVIKIAWALNKGVKTEYKQFWDVDLGVTYIPWEKVKVDDLDGFAEGGMIDQETVNAEWETVKTSEPVKETVQTTQSPAAVEKETVVTTQSEVFPPPVTMLQIPVAPTVPAVSLVPPAFPVSMPVPPPGFSPIPPPPFLRASFNPSQPPPGFMPPPVPPPVVPPPAIPPVVPTSLVQPPLSMTPETVKDVGFGSLVLPGGSVAGNLAPSTLPAGNVFNPPSKAEPEEKVPHLTEHQIPSGENTRPVIPSDIPSSAPMLAQPPGASNTSGILCVQRPNVSSNSEILGVRPANVSNSAAIMGAQPPNMLNNSGILGIQPPNVSSGSGLLGVLPPNLPNNSGLVGLQPPNVTNPAGLLGTQPPIGPQNLPPLTIPAQRMPALPMLDIRPGLIAQAPGPRFPLLQPGIPPQRGIPPPSVLDAALHPPPRGPFPPGDLFSQPERPFLAPGRPNIDSVPNPDKRIPLGNDNIQQEGDRDYRFPPIETREGINRPPPVDVRDVVGRPIDPREGPGRPPLDGRDHFGRPPVDMRETLVRPGLDHLGRRDHFGFPPEKPWGPRDFDEREHRVLPVFGGPKGLHEERGRFRAGNYRFDPRSGPWNRGFGQEVHRDFDDRRRPWERQRDRDDRDFDFCREINGNRLGRDRIQNTWVPPPHARVFDYFEGATSQRKGENVPQVNGGNTERHAPPPPLPVQKDPELYEKLASSGDADKEESGTAAGVESEAVVESTETEGT
uniprot
proteins
function
FUNCTION: Anti-terminator protein required to prevent early mRNA termination during transcription. Together with SCAF4, acts by suppressing the use of early, alternative poly(A) sites, thereby preventing the accumulation of non-functional truncated proteins. Mechanistically, associates with the phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit (POLR2A), and subsequently binds nascent RNA upstream of early polyadenylation sites to prevent premature mRNA transcript cleavage and polyadenylation. Independently of SCAF4, also acts as a positive regulator of transcript elongation. {ECO:0000250|UniProtKB:Q9UPN6}.
uniprot
proteins
mass_dalton
139504
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8692929
uniprot
proteins
pubmed
9528809
uniprot
proteins
sequence_length
1268
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:9528809}. Nucleus matrix {ECO:0000269|PubMed:9528809}. Note=Detected in granular nuclear foci which correspond to sites of active transcription. {ECO:0000250|UniProtKB:Q9UPN6}.
uniprot
proteins