Scg5
entrez
25719
canonical
uniprot
P27682
canonical
ensembl
ENSRNOG00000007542
resolver
ensembl
ENSRNOG00055002745
resolver
ensembl
ENSRNOG00060020133
resolver
ensembl
ENSRNOG00065015742
resolver
ensp
ENSRNOP00000010679
resolver
ensp
ENSRNOP00055003207
resolver
ensp
ENSRNOP00060028609
resolver
ensp
ENSRNOP00065020559
resolver
enst
ENSRNOT00000010679
resolver
enst
ENSRNOT00055004321
resolver
enst
ENSRNOT00060034840
resolver
enst
ENSRNOT00065026142
resolver
genesymbol
Scg5
resolver
genesymbol_syn
Sgne1
resolver
uniprot
G3V714
resolver
uniprot_entry
7B2_RAT
resolver
uniprot_entry
G3V714_RAT
resolver
amino_acid_sequence
MTSRMAILSGLLFWLLLEWNPAFAYSPRTPDRVSETDIQRLLHGVMEQLGIARPRVEYPAHQAMNLVGPQSIEGGAHEGLQHLGPFGNIPNIVAELTGDNIPKDFSEDQGYPDPPNPCPLGKTADDGCLENAPDTAEFSREFQLDQHLFDPEHDYPGLGKWNKKLLYEKMKGGQRRKRRSVNPYLQGKRLDNVVAKKSVPHFSEEEKEPE
uniprot
proteins
function
FUNCTION: Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro.
uniprot
proteins
mass_dalton
23684
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved in the Golgi by a furin-like convertase to generate bioactive peptides. {ECO:0000250|UniProtKB:P12961}.; PTM: Sulfated on tyrosine residues. {ECO:0000250|UniProtKB:P12961}.
uniprot
proteins
protein_family
7B2 family
uniprot
proteins
pubmed
11439082
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1709861
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
210
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P01165}. Note=Neuroendocrine and endocrine secretory granules. {ECO:0000250|UniProtKB:P01165}.
uniprot
proteins