Psmc1
entrez
19179
canonical
uniprot
P62192
canonical
ensembl
ENSMUSG00000021178
resolver
ensp
ENSMUSP00000021595
resolver
enst
ENSMUST00000021595
resolver
genesymbol
Psmc1
resolver
uniprot
P49014
resolver
uniprot
Q03527
resolver
uniprot
Q542I9
resolver
uniprot
Q96AZ3
resolver
uniprot_entry
PRS4_MOUSE
resolver
uniprot_entry
Q542I9_MOUSE
resolver
uniprot_sec
P49014
resolver
uniprot_sec
Q03527
resolver
uniprot_sec
Q96AZ3
resolver
amino_acid_sequence
MGQSQSGGHGPGGGKKDDKDKKKKYEPPVPTRVGKKKKKTKGPDAASKLPLVTPHTQCRLKLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQEEERSKVDDLRGTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL
uniprot
proteins
function
FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC1 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides. {ECO:0000250|UniProtKB:P62191}.
uniprot
proteins
mass_dalton
49185
uniprot
proteins
protein_family
AAA ATPase family
uniprot
proteins
pubmed
11562482
uniprot
proteins
pubmed
15358861
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16249333
uniprot
proteins
pubmed
16709668
uniprot
proteins
pubmed
16857966
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
8808288
uniprot
proteins
sequence_length
440
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Membrane {ECO:0000250|UniProtKB:P62191}; Lipid-anchor {ECO:0000250|UniProtKB:P62191}.
uniprot
proteins