PDCD1LG2
entrez
80380
canonical
uniprot
Q9BQ51
canonical
ensembl
ENSG00000197646
resolver
ensp
ENSP00000380855
resolver
ensp
ENSP00000793424
resolver
genesymbol
PDCD1LG2
resolver
genesymbol_syn
B7DC
resolver
genesymbol_syn
CD273
resolver
genesymbol_syn
PDCD1L2
resolver
genesymbol_syn
PDL2
resolver
hgnc
HGNC:18731
resolver
uniprot
Q14CN8
resolver
uniprot
Q5T7Z6
resolver
uniprot
Q6JXL8
resolver
uniprot
Q6JXL9
resolver
uniprot_entry
PD1L2_HUMAN
resolver
uniprot_sec
Q14CN8
resolver
uniprot_sec
Q5T7Z6
resolver
uniprot_sec
Q6JXL8
resolver
uniprot_sec
Q6JXL9
resolver
amino_acid_sequence
MIFLLLMLSLELQLHQIAALFTVTVPKELYIIEHGSNVTLECNFDTGSHVNLGAITASLQKVENDTSPHRERATLLEEQLPLGKASFHIPQVQVRDEGQYQCIIIYGVAWDYKYLTLKVKASYRKINTHILKVPETDEVELTCQATGYPLAEVSWPNVSVPANTSHSRTPEGLYQVTSVLRLKPPPGRNFSCVFWNTHVRELTLASIDLQSQMEPRTHPTWLLHIFIPFCIIAFIFIATVIALRKQLCQKLYSSKDTTKRPVTTTKREVNSAI
uniprot
proteins
function
FUNCTION: Plays a critical role in induction and maintenance of immune tolerance to self (PubMed:11224527, PubMed:12538684). Acts as a ligand for the inhibitory receptor PDCD1/PD-1, inhibiting T-cell proliferation by blocking cell cycle progression and cytokine production (PubMed:11224527). {ECO:0000269|PubMed:11224527, ECO:0000269|PubMed:12538684}.
uniprot
proteins
mass_dalton
30957
uniprot
proteins
protein_family
BTN/MOG family
uniprot
proteins
protein_family
Immunoglobulin superfamily
uniprot
proteins
pubmed
11224527
uniprot
proteins
pubmed
11283156
uniprot
proteins
pubmed
12538684
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15253154
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
273
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305|PubMed:15253154}.; SUBCELLULAR LOCATION: [Isoform 2]: Endomembrane system {ECO:0000269|PubMed:15253154}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:15253154}; Single-pass type I membrane protein {ECO:0000305|PubMed:15340161}.
uniprot
proteins
transmembrane_region
TRANSMEM 221..241; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins