Ap4s1
entrez
11782
canonical
uniprot
Q9WVL1
canonical
ensembl
ENSMUSG00000020955
resolver
ensp
ENSMUSP00000021338
resolver
ensp
ENSMUSP00000252976
resolver
ensp
ENSMUSP00000252981
resolver
enst
ENSMUST00000021338
resolver
genesymbol
Ap4s1
resolver
uniprot_entry
AP4S1_MOUSE
resolver
amino_acid_sequence
MIKFFLMVNKQGQTRLSKYYEHVDINKRALLETEVSKSCLSRSSEQCSFIEYKDFKLIYRQYAALFVVVGVNDTENEMAIYEFIHNFVEVLDGYFSRVSELDIMFNLDKVHIILDEMVLNGCIVETNRARILAPLLILDKLSES
uniprot
proteins
function
FUNCTION: Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. It is also involved in protein sorting to the basolateral membrane in epithelial cells and the proper asymmetric localization of somatodendritic proteins in neurons. AP-4 is involved in the recognition and binding of tyrosine-based sorting signals found in the cytoplasmic part of cargos, but may also recognize other types of sorting signal. {ECO:0000250|UniProtKB:Q9Y587}.
uniprot
proteins
mass_dalton
16818
uniprot
proteins
protein_family
Adaptor complexes small subunit family
uniprot
proteins
pubmed
10066790
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
144
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q9Y587}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9Y587}.
uniprot
proteins