Mgst3
entrez
66447
canonical
uniprot
Q9CPU4
canonical
ensembl
ENSMUSG00000026688
resolver
ensp
ENSMUSP00000028005
resolver
enst
ENSMUST00000028005
resolver
genesymbol
Mgst3
resolver
uniprot
Q3UXC5
resolver
uniprot
Q9D834
resolver
uniprot_entry
MGST3_MOUSE
resolver
uniprot_sec
Q3UXC5
resolver
uniprot_sec
Q9D834
resolver
amino_acid_sequence
MAVLSKEYGFVLLTGAASFVMVLHLAINVGKARKKYKVEYPVMYSTDPENGHMFNCIQRAHQNTLEVYPPFLFFLTVGGVYHPRIASGLGLAWIIGRVLYAYGYYTGDPSKRYRGAVGSLALFALMGTTVCSAFQHLGWIRPGLGYGSRSCHH
uniprot
proteins
ec_number
1.11.1.-
uniprot
proteins
ec_number
2.5.1.-
uniprot
proteins
ec_number
4.4.1.20
uniprot
proteins
function
FUNCTION: Displays both glutathione S-transferase and glutathione peroxidase activities toward oxyeicosanoids. Catalyzes the Michael addition reaction of reduced glutathione (GSH) to electrophilic eicosanoids to form GSH adducts, as part of detoxification or metabolic shunt processes. Mediates GSH conjugation to leukotriene A4 to form the sulfidopeptide leukotriene C4. Metabolizes cyclopentenone prostanoids, specifically mediates GSH addition at C9 within the cyclopentenone ring of 15-deoxy-Delta12,14-prostaglandin J2 (15dPGJ2) to form 15dPGJ2-glutathione. L-cysteine cannot substitute for GSH. Catalyzes the reduction of eicosanoid peroxides to yield eicosanoid hydroxides. {ECO:0000250|UniProtKB:O14880}.
uniprot
proteins
mass_dalton
16958
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; leukotriene C4 biosynthesis. {ECO:0000250|UniProtKB:O14880}.; PATHWAY: Lipid metabolism; arachidonate metabolism. {ECO:0000250|UniProtKB:O14880}.
uniprot
proteins
protein_family
MAPEG family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
153
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250|UniProtKB:O14880}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..29; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 71..91; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 120..140; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins