Ncs1
entrez
65153
canonical
uniprot
P62168
canonical
ensembl
ENSRNOG00000064701
resolver
ensembl
ENSRNOG00055007375
resolver
ensembl
ENSRNOG00060032673
resolver
ensembl
ENSRNOG00065021842
resolver
ensp
ENSRNOP00000091251
resolver
ensp
ENSRNOP00055009728
resolver
ensp
ENSRNOP00060046809
resolver
ensp
ENSRNOP00065029968
resolver
enst
ENSRNOT00000111270
resolver
enst
ENSRNOT00055012276
resolver
enst
ENSRNOT00060056643
resolver
enst
ENSRNOT00065037160
resolver
genesymbol
Ncs1
resolver
genesymbol_syn
Flup
resolver
genesymbol_syn
Freq
resolver
uniprot
P36610
resolver
uniprot
Q9UK26
resolver
uniprot_entry
NCS1_RAT
resolver
uniprot_sec
P36610
resolver
uniprot_sec
Q9UK26
resolver
amino_acid_sequence
MGKSNSKLKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGDPTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNEMLDIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKNADGKLTLQEFQEGSKADPSIVQALSLYDGLV
uniprot
proteins
function
FUNCTION: Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel. {ECO:0000269|PubMed:17502602}.
uniprot
proteins
mass_dalton
21879
uniprot
proteins
mutagenesis
MUTAGEN 73; /note="D->A: Loss of magnesium-binding; when associated with Q-84, A-109 and Q-120."; /evidence="ECO:0000269|PubMed:18199453"; MUTAGEN 84; /note="E->Q: Loss of magnesium-binding; when associated with A-73, A-109 and Q-120."; /evidence="ECO:0000269|PubMed:18199453"; MUTAGEN 109; /note="D->A: Loss of magnesium-binding; when associated with A-73, Q-84 and Q-120."; /evidence="ECO:0000269|PubMed:18199453"; MUTAGEN 120; /note="E->Q: Loss of magnesium-binding; when associated with A-73, Q-84 and A-109."; /evidence="ECO:0000269|PubMed:18199453
uniprot
proteins
protein_family
Recoverin family
uniprot
proteins
pubmed
10514519
uniprot
proteins
pubmed
11526106
uniprot
proteins
pubmed
17502602
uniprot
proteins
pubmed
18199453
uniprot
proteins
pubmed
19109914
uniprot
proteins
pubmed
25979333
uniprot
proteins
pubmed
7488079
uniprot
proteins
sequence_length
190
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:11526106}. Postsynaptic density {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:P62166}. Cytoplasm {ECO:0000269|PubMed:11526106}. Cell membrane {ECO:0000269|PubMed:11526106}. Membrane {ECO:0000250|UniProtKB:P62166, ECO:0000269|PubMed:10514519}; Lipid-anchor {ECO:0000250|UniProtKB:P62166}. Note=Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions. {ECO:0000250|UniProtKB:P62166, ECO:0000269|PubMed:11526106, ECO:0000305}.
uniprot
proteins