Shc4
entrez
271849
canonical
uniprot
Q6S5L9
canonical
ensembl
ENSMUSG00000035109
resolver
ensp
ENSMUSP00000043146
resolver
ensp
ENSMUSP00000106103
resolver
ensp
ENSMUSP00000106106
resolver
enst
ENSMUST00000042246
resolver
enst
ENSMUST00000110477
resolver
enst
ENSMUST00000110480
resolver
genesymbol
Shc4
resolver
genesymbol_syn
Shcd
resolver
uniprot
A2AUN0
resolver
uniprot
Q8CB26
resolver
uniprot_entry
A2AUN0_MOUSE
resolver
uniprot_entry
Q8CB26_MOUSE
resolver
uniprot_entry
SHC4_MOUSE
resolver
amino_acid_sequence
MRERSQDSQAGLTLYVGLFGHLGMLHRTKYSRFRNESITSLDEGSPGGSVGNKGSSPPPYPALAPHLPTEDATVSSQESPTALCTLIPRMASMKLANPITFLGLKTFCLGTKQVSRLKLQENQDQTPSRPASPESNLNRTGPAPAPDPDQVGRRPTSLRPDTCPLPGPGEPSPRSKQDGPPLQHLLGNGLNYCVRYMGCIEVLQSMRSLDFGMRTQVTREAISRLCEAVPGAHGAIKKRKAPVKFLTTVLGKSNLQFSGMNIKLTVSTSSLTLMNLDNQQIIANHQMQSISFASGGDPDTTDYVAYVAKDPVNQRACHILECRSGMAQDVISTIGQAFELRFKQYLKNPSLNTWEREEVLVDGAPEDRDHDYYNSIPGKQPPEGGISDVRIQAQATDQMAYCPIRCEKLCYLPGNSTCSGVYKNCMGRSRPIGIPHERAGQGDTPSLRHFWRVDLFDDPCYVNTQALQSMHSYAGNQSSALPQGSPWHLGKAPETVQPGATAKPGSALALPHIRQQLWDEECFHGKLSRGAAEKLLVKDGDFLVRESVTSPGQFVLSGLQGGQAKHLLLVDPEGKVRTKDHVFDNVGHLIKYHMDNNLPIISSGSEVRLKQPIRKYDNTGLLPPKK
uniprot
proteins
function
FUNCTION: Activates both Ras-dependent and Ras-independent migratory pathways in melanomas. Contributes to the early phases of agrin-induced tyrosine phosphorylation of CHRNB1. {ECO:0000269|PubMed:17452444}.
uniprot
proteins
mass_dalton
68519
uniprot
proteins
post_translational_modification
PTM: Phosphorylated; the phosphorylation is enhanced by EGF. Phosphorylation at Tyr-422 is required for the interaction with GRB2 (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
17409413
uniprot
proteins
pubmed
17452444
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
626
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000269|PubMed:17452444}. Note=Colocalized with MUSK at the neuromuscular junction.
uniprot
proteins