SEC14L1
entrez
6397
canonical
uniprot
Q92503
canonical
ensembl
ENSG00000129657
resolver
ensp
ENSP00000376268
resolver
ensp
ENSP00000389838
resolver
ensp
ENSP00000390392
resolver
ensp
ENSP00000406030
resolver
ensp
ENSP00000408169
resolver
ensp
ENSP00000466581
resolver
ensp
ENSP00000545209
resolver
genesymbol
SEC14L1
resolver
genesymbol_syn
SEC14L
resolver
hgnc
HGNC:10698
resolver
uniprot
A5PLM6
resolver
uniprot
A8K4E8
resolver
uniprot
B4DDI5
resolver
uniprot
D5G3K1
resolver
uniprot
Q59HE8
resolver
uniprot
Q99780
resolver
uniprot_entry
A5PLM6_HUMAN
resolver
uniprot_entry
Q59HE8_HUMAN
resolver
uniprot_entry
S14L1_HUMAN
resolver
uniprot_sec
A8K4E8
resolver
uniprot_sec
B4DDI5
resolver
uniprot_sec
D5G3K1
resolver
uniprot_sec
Q99780
resolver
amino_acid_sequence
MVQKYQSPVRVYKYPFELIMAAYERRFPTCPLIPMFVGSDTVNEFKSEDGAIHVIERRCKLDVDAPRLLKKIAGVDYVYFVQKNSLNSRERTLHIEAYNETFSNRVIINEHCCYTVHPENEDWTCFEQSASLDIKSFFGFESTVEKIAMKQYTSNIKKGKEIIEYYLRQLEEEGITFVPRWSPPSITTSSETSSSSSKKQAASMAVVIPEAALKEGLSGDALSSPSAPEPVVGTPDDKLDADYIKRYLGDLTPLQESCLIRLRQWLQETHKGKIPKDEHILRFLRARDFNIDKAREIMCQSLTWRKQHQVDYILETWTPPQVLQDYYAGGWHHHDKDGRPLYVLRLGQMDTKGLVRALGEEALLRYVLSINEEGLRRCEENTKVFGRPISSWTCLVDLEGLNMRHLWRPGVKALLRIIEVVEANYPETLGRLLILRAPRVFPVLWTLVSPFIDDNTRRKFLIYAGNDYQGPGGLLDYIDKEIIPDFLSGECMCEVPEGGLVPKSLYRTAEELENEDLKLWTETIYQSASVFKGAPHEILIQIVDASSVITWDFDVCKGDIVFNIYHSKRSPQPPKKDSLGAHSITSPGGNNVQLIDKVWQLGRDYSMVESPLICKEGESVQGSHVTRWPGFYILQWKFHSMPACAASSLPRVDDVLASLQVSSHKCKVMYYTEVIGSEDFRGSMTSLESSHSGFSQLSAATTSSSQSHSSSMISR
uniprot
proteins
function
FUNCTION: May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of RIGI, the cytoplasmic sensor of viral nucleic acids. Prevents the interaction of RIGI with MAVS/IPS1, an important step in signal propagation (PubMed:23843640). May also regulate the SLC18A3 and SLC5A7 cholinergic transporters (PubMed:17092608). {ECO:0000269|PubMed:17092608, ECO:0000269|PubMed:23843640}.
uniprot
proteins
mass_dalton
81250
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17092608
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23843640
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
8697811
uniprot
proteins
pubmed
9110174
uniprot
proteins
sequence_length
715
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17092608, ECO:0000269|PubMed:23843640}. Golgi apparatus {ECO:0000269|PubMed:17092608}.
uniprot
proteins