SRPRA
entrez
6734
canonical
uniprot
P08240
canonical
ensembl
ENSG00000182934
resolver
ensp
ENSP00000328023
resolver
ensp
ENSP00000435508
resolver
ensp
ENSP00000779416
resolver
ensp
ENSP00000784181
resolver
genesymbol
SRPRA
resolver
genesymbol_syn
SRPR
resolver
hgnc
HGNC:11307
resolver
uniprot
A6NIB3
resolver
uniprot
B2R5Z8
resolver
uniprot
B4E0H3
resolver
uniprot
E9PJS4
resolver
uniprot
Q9BVJ4
resolver
uniprot_entry
SRPRA_HUMAN
resolver
uniprot_sec
A6NIB3
resolver
uniprot_sec
B2R5Z8
resolver
uniprot_sec
B4E0H3
resolver
uniprot_sec
E9PJS4
resolver
uniprot_sec
Q9BVJ4
resolver
amino_acid_sequence
MLDFFTIFSKGGLVLWCFQGVSDSCTGPVNALIRSVLLQERGGNNSFTHEALTLKYKLDNQFELVFVVGFQKILTLTYVDKLIDDVHRLFRDKYRTEIQQQSALSLLNGTFDFQNDFLRLLREAEESSKIRAPTTMKKFEDSEKAKKPVRSMIETRGEKPKEKAKNSKKKGAKKEGSDGPLATSKPVPAEKSGLPVGPENGVELSKEELIRRKREEFIQKHGRGMEKSNKSTKSDAPKEKGKKAPRVWELGGCANKEVLDYSTPTTNGTPEAALSEDINLIRGTGSGGQLQDLDCSSSDDEGAAQNSTKPSATKGTLGGMFGMLKGLVGSKSLSREDMESVLDKMRDHLIAKNVAADIAVQLCESVANKLEGKVMGTFSTVTSTVKQALQESLVQILQPQRRVDMLRDIMDAQRRQRPYVVTFCGVNGVGKSTNLAKISFWLLENGFSVLIAACDTFRAGAVEQLRTHTRRLSALHPPEKHGGRTMVQLFEKGYGKDAAGIAMEAIAFARNQGFDVVLVDTAGRMQDNAPLMTALAKLITVNTPDLVLFVGEALVGNEAVDQLVKFNRALADHSMAQTPRLIDGIVLTKFDTIDDKVGAAISMTYITSKPIVFVGTGQTYCDLRSLNAKAVVAALMKA
uniprot
proteins
function
FUNCTION: Component of the signal recognition particle (SRP) complex receptor (SR) (PubMed:16439358). Ensures, in conjunction with the SRP complex, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system (PubMed:16675701, PubMed:34020957). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SRP subunit SRP54 (PubMed:34020957). SRP receptor compaction and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER (PubMed:34020957). {ECO:0000269|PubMed:16439358, ECO:0000269|PubMed:16675701, ECO:0000269|PubMed:34020957}.
uniprot
proteins
mass_dalton
69811
uniprot
proteins
mutagenesis
MUTAGEN 407; /note="R->A: Reduced SR compaction. Impaired interaction with SRP. Impaired detachement from ribosome. Does not impair GTP hydrolysis by the SRP-SR complex."; /evidence="ECO:0000269|PubMed:34020957
uniprot
proteins
protein_family
GTP-binding SRP family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16439358
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16675701
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
30550790
uniprot
proteins
pubmed
3340536
uniprot
proteins
pubmed
34020957
uniprot
proteins
sequence_length
638
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P32916}; Peripheral membrane protein {ECO:0000250|UniProtKB:P32916}; Cytoplasmic side {ECO:0000250|UniProtKB:P32916}. Note=Thought to be anchored in the membrane through an interaction with SR-beta, which contains a bona fide transmembrane domain. {ECO:0000250|UniProtKB:P32916}.
uniprot
proteins