Q6P720
uniprot
Q6P720
canonical
amino_acid_sequence
MKPPDRPTPGRTDRILGVMGGMLRACAVPGQEGPQERDPLGPGSTKTESECTEEDQTGEREREVLAWAPQPESYSIAGSEGSMSASAVSGLAALSGPSSGLSSHPCSPVPPGPVTGLRRWLDHSKHCLSVETEADSGQTRQCENWMLEPTLTTGQELPELTLLTTLLEGPGVKAQPAEEETLSQAPKNEEEQKKTALERSMFVLSELVETERMYVDDLGQIVEGYMATMATQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQQCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVLSEFGDSYFEELRQQLGHRLQLSDLLIKPVQRIMKYQLLLKDFLKYYRRAGMDTEELEQAVEVMCFVPKRCNDMMSLGRLRGFEGKLTAQGKLLGQDTFLVTEPEAGGLLSSRGRERRVFLFEQIVIFSEALGGGGRGGTQPGYVYKNSIKASDPAVSQAWIKQVAQILESQRDFLNALQSPIEYQRRESQTNSLGRSGGPGVGSPGRMAQVSMHTPINGSLPSLLLLPRGEVPRAPLPLDTQALSETPLTPYDPPALPTVNSPPGQARLAKLDEDEL
uniprot
proteins
function
FUNCTION: May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
64160
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
579
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Highly colocalizes with actin regions. {ECO:0000250}.
uniprot
proteins