TRIM40
entrez
135644
canonical
uniprot
Q6P9F5
canonical
ensembl
ENSG00000172524
resolver
ensembl
ENSG00000204614
resolver
ensembl
ENSG00000224496
resolver
ensembl
ENSG00000227458
resolver
ensembl
ENSG00000228001
resolver
ensembl
ENSG00000233931
resolver
ensembl
ENSG00000236399
resolver
ensembl
ENSG00000237046
resolver
ensp
ENSP00000308310
resolver
ensp
ENSP00000379826
resolver
ensp
ENSP00000402617
resolver
ensp
ENSP00000414258
resolver
ensp
ENSP00000414769
resolver
ensp
ENSP00000448384
resolver
ensp
ENSP00000479007
resolver
ensp
ENSP00000480009
resolver
ensp
ENSP00000553325
resolver
enst
ENST00000425845
resolver
enst
ENST00000430485
resolver
enst
ENST00000431397
resolver
enst
ENST00000548672
resolver
enst
ENST00000614405
resolver
enst
ENST00000618891
resolver
genesymbol
TRIM40
resolver
genesymbol_syn
RNF35
resolver
hgnc
HGNC:18736
resolver
uniprot
A0A0G2JIV5
resolver
uniprot
A0A0G2JMU7
resolver
uniprot
Q5SRJ6
resolver
uniprot
Q5SS36
resolver
uniprot
Q8TD96
resolver
uniprot_entry
A0A0G2JIV5_HUMAN
resolver
uniprot_entry
A0A0G2JMU7_HUMAN
resolver
uniprot_entry
TRI40_HUMAN
resolver
uniprot_sec
Q5SRJ6
resolver
uniprot_sec
Q5SS36
resolver
uniprot_sec
Q8TD96
resolver
amino_acid_sequence
MIPLQKDNQEEGVCPICQESLKEAVSTNCGHLFCRVCLTQHVEKASASGVFCCPLCRKPCSEEVLGTGYICPNHQKRVCRFCEESRLLLCVECLVSPEHMSHHELTIENALSHYKERLNRRSRKLRKDIAELQRLKAQQEKKLQALQFQVDHGNHRLEAGPESQHQTREQLGALPQQWLGQLEHMPAEAARILDISRAVTQLRSLVIDLERTAKELDTNTLKNAGDLLNRSAPQKLEVIYPQLEKGVSELLLQPPQKL
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that plays a role in the limitation of the innate immune response (PubMed:21474709, PubMed:29117565). Mediates inhibition of the RLR signaling pathway by ubiquitinating RIGI and IFIH1 receptors, leading to their proteasomal degradation (PubMed:21474709). Also promotes the neddylation of IKBKG/NEMO, stabilizing NFKBIA, and thereby inhibiting of NF-kappa-B nuclear translocation and activation (PubMed:21474709). {ECO:0000269|PubMed:21474709, ECO:0000269|PubMed:29117565}.
uniprot
proteins
mass_dalton
29336
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
12622776
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16702430
uniprot
proteins
pubmed
21474709
uniprot
proteins
pubmed
29117565
uniprot
proteins
sequence_length
258
uniprot
proteins