Prp4k
entrez
19134
canonical
uniprot
Q61136
canonical
ensembl
ENSMUSG00000021413
resolver
ensp
ENSMUSP00000077019
resolver
ensp
ENSMUSP00000152654
resolver
ensp
ENSMUSP00000215861
resolver
enst
ENSMUST00000077853
resolver
enst
ENSMUST00000222509
resolver
genesymbol
Prp4k
resolver
genesymbol
Prpf4b
resolver
genesymbol_syn
Cbp143
resolver
genesymbol_syn
Prp4h
resolver
genesymbol_syn
Prp4m
resolver
genesymbol_syn
Prpf4b
resolver
genesymbol_syn
Prpk
resolver
uniprot
B2RUN6
resolver
uniprot
O88378
resolver
uniprot
Q8BND8
resolver
uniprot
Q8C5G1
resolver
uniprot
Q8R4Y5
resolver
uniprot
Q9CTL9
resolver
uniprot
Q9CTT0
resolver
uniprot_entry
PRP4K_MOUSE
resolver
uniprot_entry
Q8C5G1_MOUSE
resolver
uniprot_sec
B2RUN6
resolver
uniprot_sec
O88378
resolver
uniprot_sec
Q8BND8
resolver
uniprot_sec
Q8R4Y5
resolver
uniprot_sec
Q9CTL9
resolver
uniprot_sec
Q9CTT0
resolver
amino_acid_sequence
MAATEPPSLREQAEMDDADNSEKSVNEENGEVSEDQSQNKHSRHKKKKHKHRSKHKKHKHSSEEDRDKKHKHKHKHKKHKRKEVIEASDKEGLSPAKRTKLDDLALLEDLEKQRALIKAELDNELMEGKVQSGMGLILQGYESGSEEEGEIHEKARNGNRSSTRSSSTRGKLEITDNKNSAKKRSKSRSKERTRHRSDKRKSKGAGEMLREKANRSKSKERRKSKSPSKRSKSQDQARKSKSPPLRRRSQEKVGKARSPAEEKMKSEEKGKIKDRKKSPIVNERSRDRSKKSKSPVDLRDKSKDRRSRSKERKSKRSEIDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKRRSLSPKLRDKSRRSRSPLLNDRRSKQSKSPSRTLSPGRRAKSRSLERKRREPERRRLSSPRTRPRDDILGRCERSKDASPINRWSPTRRRSRSPIRRRSRSPLRRSRSPRRRSRSPRRRDRSRRSRSRLRRRSRSRGGHRRRSRSKVKEDKFKGSLSEGMKVEQESSSDDNLEDFDVEEEDEEALIEQRRIQRQAIVQKYKYLAEDSNISVPSEPSSPQSSTRSRSPSPDDILERVAADVKEYERENVDTFEASVKAKHNLMTVEQNNGSSQKKILAPDMFTESDDMFAAYFDSARLRAAGIGKDFKENPNLRDNWTDAEGYYRVNIGEVLDKRYNVYGYTGQGVFSNVVRARDNARANQEVAVKIIRNNELMQKTGLKELEFLKKLNDADPDDKFHCLRLFRHFYHKQHLCLVFEPLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREKVTVMSTINPTKDLLADLIGCQRLPEDQRKKVHQLKDLLDQILMLDPAKRISINQALQHAFIQEKI
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine kinase involved in spliceosomal assembly as well as mitosis and signaling regulation. Connects chromatin mediated regulation of transcription and pre-mRNA splicing. During spliceosomal assembly, interacts with and phosphorylates PRPF6 and PRPF31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), to facilitate the formation of the spliceosome B complex. Plays a role in regulating transcription and the spindle assembly checkpoint (SAC). Associates with U5 snRNP and NCOR1 deacetylase complexes which may allow a coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation. Associates and probably phosphorylates SMARCA4 and NCOR1. Phosphorylates SRSF1. Associates with kinetochores during mitosis and is necessary for recruitment and maintenance of the checkpoint proteins such as MAD1L1 and MAD12L1 at the kinetochores. Phosphorylates and regulates the activity of the transcription factors such as ELK1 and KLF13. Phosphorylates nuclear YAP1 and WWTR1/TAZ which induces nuclear exclusion and regulates Hippo signaling pathway, involved in tissue growth control. {ECO:0000250|UniProtKB:Q13523}.
uniprot
proteins
mass_dalton
116976
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CLK1. Autophosphorylated; phosphorylation inhibits interaction with its targets, such as PRPF6 or SMARCA4. {ECO:0000250|UniProtKB:Q13523}.
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
12077342
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
9102632
uniprot
proteins
pubmed
9701556
uniprot
proteins
sequence_length
1007
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12077342}. Chromosome, centromere, kinetochore {ECO:0000250|UniProtKB:Q13523}. Note=Located throughout the nucleus, excluding the nucleolus but enriched in multiple speckles. {ECO:0000269|PubMed:12077342}.
uniprot
proteins