Prmt3
entrez
89820
canonical
uniprot
O70467
canonical
ensembl
ENSRNOG00000014829
resolver
ensp
ENSRNOP00000020853
resolver
ensp
ENSRNOP00000069745
resolver
enst
ENSRNOT00000020853
resolver
enst
ENSRNOT00000079655
resolver
genesymbol
Prmt3
resolver
genesymbol_syn
Hrmt1l3
resolver
uniprot
A0A0G2JW52
resolver
uniprot_entry
A0A0G2JW52_RAT
resolver
uniprot_entry
ANM3_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by N-ethylmaleimide and high concentrations of zinc chloride. {ECO:0000269|PubMed:10931850}.
uniprot
proteins
amino_acid_sequence
MCSLAAGNGQGAELGPEPLELSDSGDDAGWEDEDADAEPAQGRQHTPCLFCDRLFRSAEETFSHCKLEHQFNIDGMVHKHGLEFYGYIKLINFIRLKNPTVEYMNSIYNPVPWDKDEYLKPVLEDDLLLQFDVEDLYEPVSAPFTYPNGLSENTSAVEKLKLMEARALSAEAALARAREDLQKMKQFAQDFVMNVDVRTCSSTTTIADLQEDEDGVYFSSYGHYGIHEEMLKDKVRTESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGAKKVIAVDQSEILYQAMDIIRLNKLEDTIVLIKGKIEEVSLPVEKVDVIISEWMGYFLLFESMLDSVLYAKSKYLAKGGSVYPDICTISLVAVSDVSKHADRIAFWDDVYGFNMSCMKKAVIPEAVVEVVDHKTLISDPCDIKHIDCHTTSISDLEFSSDFTLRTTKTAMCTAVAGYFDIYFEKNCHNRVVFSTGPQSTKTHWKQTIFLLEKPFPVKAGEALKGKITVHKNKKDPRSLIVTLTLNSSTQTYSLQ
uniprot
proteins
ec_number
2.1.1.319
uniprot
proteins
function
FUNCTION: Protein-arginine N-methyltransferase that catalyzes both the monomethylation and asymmetric dimethylation of the guanidino nitrogens of arginine residues in target proteins, and therefore falls into the group of type I methyltransferases (PubMed:10899106, PubMed:15334060, PubMed:9642256). Catalyzes the asymmetric arginine dimethylation at multiple sites in the Arg/Gly-rich region of small ribosomal subunit protein uS5/RPS2 (By similarity). Also appears to methylate other ribosomal proteins (By similarity). May regulate retinoic acid synthesis and signaling by inhibiting ALDH1A1 retinal dehydrogenase activity (By similarity). Contributes to methylation of histone H4 'Arg-3', a specific tag for epigenetic transcriptional activation (By similarity). Promotes osteogenesis (By similarity). {ECO:0000250|UniProtKB:O60678, ECO:0000250|UniProtKB:Q922H1, ECO:0000269|PubMed:10899106, ECO:0000269|PubMed:15334060, ECO:0000269|PubMed:9642256}.
uniprot
proteins
mass_dalton
59420
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
Protein arginine N-methyltransferase family
uniprot
proteins
pubmed
10899106
uniprot
proteins
pubmed
10931850
uniprot
proteins
pubmed
15334060
uniprot
proteins
pubmed
9642256
uniprot
proteins
sequence_length
528
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:9642256}. Nucleus {ECO:0000250|UniProtKB:O60678}.
uniprot
proteins