P20067
uniprot
P20067
canonical
amino_acid_sequence
MKVASGSAAAAAGPSCSLKAGRTAGEVVLGLSEQSVAISRCAGTRLPALLDEQQVNVLLYDMNGCYSRLKELVPTLPQNRKVSKVEILQHVIDYIRDLQLELNSESEVGTTGGRGLPVRAPLSTLNGEISALAAEVRSESEYYIILQWETEATGGGCPPSLLFRRIAI
uniprot
proteins
function
FUNCTION: Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation. Inhibits skeletal muscle and cardiac myocyte differentiation. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-BMAL1 heterodimer. {ECO:0000269|PubMed:16556596, ECO:0000269|PubMed:19217292}.
uniprot
proteins
mass_dalton
17914
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated; which is favored by Ifi204 and leads to proteasomal degradation. {ECO:0000250}.
uniprot
proteins
pubmed
11940648
uniprot
proteins
pubmed
15451666
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16516211
uniprot
proteins
pubmed
16556596
uniprot
proteins
pubmed
19217292
uniprot
proteins
pubmed
2156629
uniprot
proteins
pubmed
8765747
uniprot
proteins
sequence_length
168
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16516211}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981, ECO:0000269|PubMed:16516211}.
uniprot
proteins