Itga7
entrez
81008
canonical
uniprot
Q63258
canonical
ensembl
ENSRNOG00000007905
resolver
ensp
ENSRNOP00000106763
resolver
enst
ENSRNOT00000145353
resolver
genesymbol
Itga7
resolver
uniprot
A0ABK0L8Y1
resolver
uniprot
Q5HZX9
resolver
uniprot
Q63026
resolver
uniprot
Q63027
resolver
uniprot_entry
A0ABK0L8Y1_RAT
resolver
uniprot_entry
ITA7_RAT
resolver
uniprot_sec
Q5HZX9
resolver
uniprot_sec
Q63026
resolver
uniprot_sec
Q63027
resolver
amino_acid_sequence
MARIPRCDFLGLPGICYLLSFLLAGLLLPRASAFNLDVMGAIRKEGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQANRTGGLFACPLSLEETDCYRVDIDRGANVQKESKENQWLGVSVRSQGAGGKVVTCAHRYESRQRVDQVLETRDVIGRCFVLSQDLAIRDELDGGEWKFCEGRPQGHEQFGFCQQGTAATFSPDSHYLIFGAPGTYNWKGLLFVTNIDSSDPDQLVYKTLDPADRLTGPAGDLTLNSYLGFSIDSGKGLMRSEELSFVAGAPRANHKGAVVILRKDSASRLIPEVVLSGERLTSGFGYSLAVTDLNSDGWADLIVGAPYFFERQEELGGAVYVYMNQGGHWADISPLRLCGSPDSMFGISLAVLGDLNQDGFPDIAVGAPFDGDGKVFIYHGSSLGVVTKPSQVLEGEAVGIKSFGYSLSGGLDVDGNHYPDLLVGSLADTAALFRARPVLHVSQEIFIDPRAIDLEQPNCADGRLVCVHVKVCFSYVAVPSSYSPIVVLDYVLDGDTDRRLRGQAPRVTFPGRGPDDLKHQSSGTVSLKHQHDRVCGDTVFQLQENVKDKLRAIVVTLSYGLQTPRLRRQAPDQGLPLVAPILNAHQPSTQRTEIHFLKQGCGDDKICQSNLQLAQAQFCSRISDTEFQALPMDLDGTALFALSGQPFIGLELTVTNLPSDPARPQADGDDAHEAQLLATLPASLRYSGVRTLDSVEKPLCLSNENASHVECELGNPMKRGTQVTFYLILSTSGITIETTELKVELLLATISEQDLHPVSVRAHVFIELPLSISGVATPQQLFFSGKVKGESAMRSERDVGSKVKYEVTVSNQGQSLNTLGSAFLNIMWPHEIANGKWLLYPMRVELEGGQGPEKKGICSPRPNILHLDVDSRDRRRRELGQPEPQEPPEKVEPSTSWWPVSSAEKRNVTLDCAQGTAKCVVFSCPLYSFDRAAVLHVWGRLWNSTFLEEYMSVKSLEVIVRANITVKSSIKNLLLRDASTVIPVMVYLDPVAVVAEGVPWWVILLAVLAGLLVLALLVLLLWKLGFFKRAKHPEATVPQYHAVKILREDRQQFKEEKTGTIQRSNWGNSQWEGSDAHPILAADWHPELGPDGHPVSVTA
uniprot
proteins
function
FUNCTION: Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. Involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells (By similarity). Acts as a Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation. {ECO:0000250, ECO:0000269|PubMed:17598176, ECO:0000269|PubMed:20019333}.
uniprot
proteins
mass_dalton
124194
uniprot
proteins
mutagenesis
MUTAGEN 603; /note="R->G: Abolishes cleavage by urokinase."; /evidence="ECO:0000269|PubMed:18940796
uniprot
proteins
post_translational_modification
PTM: ADP-ribosylated on at least two sites of the extracellular domain in skeletal myotubes. {ECO:0000250}.; PTM: A 70 kDa form is created by proteolytic cleavage. Cleavage is elevated during myogenic differentiation and the cleaved form enhances cell adhesion and spreading on laminin. {ECO:0000269|PubMed:18940796}.
uniprot
proteins
protein_family
Integrin alpha chain family
uniprot
proteins
pubmed
1315319
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17598176
uniprot
proteins
pubmed
18940796
uniprot
proteins
pubmed
20019333
uniprot
proteins
pubmed
8126096
uniprot
proteins
pubmed
8626012
uniprot
proteins
sequence_length
1135
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 1037..1057; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins