Tmprss3
entrez
140765
canonical
uniprot
Q8K1T0
canonical
ensembl
ENSMUSG00000024034
resolver
ensp
ENSMUSP00000024833
resolver
ensp
ENSMUSP00000110196
resolver
genesymbol
Tmprss3
resolver
uniprot
Q3TZ06
resolver
uniprot
Q812A6
resolver
uniprot
Q8VDE0
resolver
uniprot_entry
Q3TZ06_MOUSE
resolver
uniprot_entry
TMPS3_MOUSE
resolver
uniprot_sec
Q812A6
resolver
uniprot_sec
Q8VDE0
resolver
amino_acid_sequence
MGENDPPAAEAPFSFRSLFGLDDLKISPVAPDGDAVAAQILSLLPLKFFPIIVIGIIALILALAIGLGIHFDCSGKYRCHSSFKCIELTARCDGVSDCKNAEDEYRCVRVSGQRAALQVFTAAAWRTMCSDDWKSHYAKIACAQLGFPSYVSSDHLRVDALEEQFQGDFVSINHLLSDDKVTALHHSVYMREGCTSGHVVTLKCSACGTRTGYSPRIVGGNMSSLTQWPWQVSLQFQGYHLCGGSIITPLWIVTAAHCVYDLYHPKSWTVQVGLVSLMDSPVPSHLVEKIIYHSKYKPKRLGNDIALMKLSEPLTFDETIQPICLPNSEENFPDGKLCWTSGWGATEDGGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLKGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRITSFLDWIHEQLERDLKT
uniprot
proteins
ec_number
3.4.21.-
uniprot
proteins
function
FUNCTION: Probable serine protease that plays a role in hearing. Acts as a permissive factor for cochlear hair cell survival and activation at the onset of hearing and is required for saccular hair cell survival. Activates ENaC (in vitro). {ECO:0000269|PubMed:12393794, ECO:0000269|PubMed:21454591}.
uniprot
proteins
mass_dalton
49506
uniprot
proteins
post_translational_modification
PTM: Undergoes autoproteolytic activation.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
12393794
uniprot
proteins
pubmed
21454591
uniprot
proteins
sequence_length
453
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12393794, ECO:0000269|PubMed:21454591}; Single-pass type II membrane protein {ECO:0000269|PubMed:12393794, ECO:0000269|PubMed:21454591}.
uniprot
proteins
transmembrane_region
TRANSMEM 49..69; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins