Hmgb2
entrez
97165
canonical
uniprot
P30681
canonical
ensembl
ENSMUSG00000054717
resolver
ensp
ENSMUSP00000065940
resolver
ensp
ENSMUSP00000300171
resolver
ensp
ENSMUSP00000300172
resolver
ensp
ENSMUSP00000341552
resolver
enst
ENSMUST00000067925
resolver
genesymbol
Hmgb2
resolver
genesymbol_syn
Hmg2
resolver
uniprot
Q3UXT1
resolver
uniprot
Q9EQD5
resolver
uniprot_entry
HMGB2_MOUSE
resolver
uniprot_sec
Q3UXT1
resolver
uniprot_sec
Q9EQD5
resolver
amino_acid_sequence
MGKGDPNKPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDLAKSDKARYDREMKNYVPPKGDKKGKKKDPNAPKRPPSAFFLFCSENRPKIKIEHPGLSIGDTAKKLGEMWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNEPEDEEEEEEEEEEEDDEEEEEDEE
uniprot
proteins
function
FUNCTION: Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. In the nucleus is an abundant chromatin-associated non-histone protein involved in transcription, chromatin remodeling and V(D)J recombination and probably other processes. Binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters by enhancing transcription factor binding and/or bringing distant regulatory sequences into close proximity (By similarity). Involved in V(D)J recombination by acting as a cofactor of the RAG complex: acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS) (PubMed:9184213). Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sensor which cooperates with subsequent discriminative sensing by specific pattern recognition receptors (PubMed:19890330). In the extracellular compartment acts as a chemokine. Promotes proliferation and migration of endothelial cells implicating AGER/RAGE (By similarity). Has antimicrobial activity in gastrointestinal epithelial tissues (By similarity). Involved in inflammatory response to antigenic stimulus coupled with pro-inflammatory activity (PubMed:25306442). May play a role in germ cell differentiation (PubMed:11262228). Involved in modulation of neurogenesis probably by regulation of neural stem proliferation (PubMed:24391977). Involved in articular cartilage surface maintenance implicating LEF1 and the Wnt/beta-catenin pathway (PubMed:19805379). {ECO:0000250|UniProtKB:P09429, ECO:0000250|UniProtKB:P26583, ECO:0000269|PubMed:19805379, ECO:0000269|PubMed:19890330, ECO:0000269|PubMed:23495099, ECO:0000269|PubMed:24391977, ECO:0000269|PubMed:25306442, ECO:0000269|PubMed:9184213, ECO:0000305|PubMed:11262228}.
uniprot
proteins
mass_dalton
24162
uniprot
proteins
post_translational_modification
PTM: Reduction/oxidation of cysteine residues Cys-23, Cys-45 and Cys-106 and a possible intramolecular disulfide bond involving Cys-23 and Cys-45 give rise to different redox forms with specific functional activities in various cellular compartments: 1- fully reduced HMGB2 (HMGB2C23hC45hC106h), 2- disulfide HMGB2 (HMGB2C23-C45C106h) and 3- sulfonyl HMGB2 (HMGB2C23soC45soC106so). {ECO:0000250|UniProtKB:P09429}.
uniprot
proteins
protein_family
HMGB family
uniprot
proteins
pubmed
11262228
uniprot
proteins
pubmed
1408807
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19805379
uniprot
proteins
pubmed
19890330
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23495099
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
24391977
uniprot
proteins
pubmed
25306442
uniprot
proteins
pubmed
7720710
uniprot
proteins
pubmed
9184213
uniprot
proteins
sequence_length
210
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P09429}. Chromosome {ECO:0000250|UniProtKB:P26583}. Cytoplasm {ECO:0000269|PubMed:19890330}. Secreted {ECO:0000250|UniProtKB:P26583}.
uniprot
proteins