KCNMB1
entrez
3779
canonical
uniprot
Q16558
canonical
ensembl
ENSG00000145936
resolver
ensp
ENSP00000274629
resolver
genesymbol
KCNMB1
resolver
hgnc
HGNC:6285
resolver
uniprot
O00707
resolver
uniprot
O00708
resolver
uniprot
P78475
resolver
uniprot
Q53YR0
resolver
uniprot
Q8TAX3
resolver
uniprot
Q93005
resolver
uniprot_entry
KCMB1_HUMAN
resolver
uniprot_sec
O00707
resolver
uniprot_sec
O00708
resolver
uniprot_sec
P78475
resolver
uniprot_sec
Q53YR0
resolver
uniprot_sec
Q8TAX3
resolver
uniprot_sec
Q93005
resolver
amino_acid_sequence
MVKKLVMAQKRGETRALCLGVTMVVCAVITYYILVTTVLPLYQKSVWTQESKCHLIETNIRDQEELKGKKVPQYPCLWVNVSAAGRWAVLYHTEDTRDQNQQCSYIPGSVDNYQTARADVEKVRAKFQEQQVFYCFSAPRGNETSVLFQRLYGPQALLFSLFWPTFLLTGGLLIIAMVKSNQYLSILAAQK
uniprot
proteins
function
FUNCTION: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate.
uniprot
proteins
mass_dalton
21797
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:10792058}.
uniprot
proteins
protein_family
KCNMB (TC 8.A.14.1) family
uniprot
proteins
protein_family
KCNMB1 subfamily
uniprot
proteins
pubmed
10489376
uniprot
proteins
pubmed
10792058
uniprot
proteins
pubmed
12136044
uniprot
proteins
pubmed
12434576
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057310
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8612769
uniprot
proteins
pubmed
8764643
uniprot
proteins
pubmed
8799178
uniprot
proteins
sequence_length
191
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 19..39; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 158..178; /note="Helical; Name=2"; /evidence="ECO:0000255
uniprot
proteins