SLC26A7
entrez
115111
canonical
uniprot
Q8TE54
canonical
ensembl
ENSG00000147606
resolver
ensp
ENSP00000276609
resolver
ensp
ENSP00000309504
resolver
ensp
ENSP00000428849
resolver
ensp
ENSP00000482686
resolver
enst
ENST00000617078
resolver
genesymbol
SLC26A7
resolver
genesymbol_syn
SUT2
resolver
hgnc
HGNC:14467
resolver
uniprot
A0A087WZI7
resolver
uniprot
Q24JS8
resolver
uniprot
Q8TE53
resolver
uniprot
Q96RN2
resolver
uniprot_entry
A0A087WZI7_HUMAN
resolver
uniprot_entry
S26A7_HUMAN
resolver
uniprot_sec
Q24JS8
resolver
uniprot_sec
Q8TE53
resolver
uniprot_sec
Q96RN2
resolver
activity_regulation
ACTIVITY REGULATION: Is active at both alkaline and acidic pH. Activity is inhibited by 4,4'-Di-isothiocyanatostilbene-2,2'-disulfonic acid (DIDS - an inhibitor of several anion channels and transporters). {ECO:0000269|PubMed:12736153}.
uniprot
proteins
amino_acid_sequence
MTGAKRKKKSMLWSKMHTPQCEDIIQWCRRRLPILDWAPHYNLKENLLPDTVSGIMLAVQQVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGHHVATGTFALTSLISANAVERIVPQNMQNLTTQSNTSVLGLSDFEMQRIHVAAAVSFLGGVIQVAMFVLQLGSATFVVTEPVISAMTTGAATHVVTSQVKYLLGMKMPYISGPLGFFYIYAYVFENIKSVRLEALLLSLLSIVVLVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGHIPQGIPSPRAPPMNILSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCIPSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGMLIQFRDLKKYWNVDKIDWGIWVSTYVFTICFAANVGLLFGVVCTIAIVIGRFPRAMTVSIKNMKEMEFKVKTEMDSETLQQVKIISINNPLVFLNAKKFYTDLMNMIQKENACNQPLDDISKCEQNTLLNSLSNGNCNEEASQSCPNEKCYLILDCSGFTFFDYSGVSMLVEVYMDCKGRSVDVLLAHCTASLIKAMTYYGNLDSEKPIFFESVSAAISHIHSNKNLSKLSDHSEV
uniprot
proteins
disease_involvement
DISEASE: Note=Disease-causing variants in SLC26A7 have been found in patients with thyroid dyshormonogenesis and congenital goitrous hypothyroidism. {ECO:0000269|PubMed:30333321, ECO:0000269|PubMed:31372509, ECO:0000269|PubMed:32486989}.
uniprot
proteins
function
FUNCTION: Acts as an anion channel mediating the transport of chloride, sulfate and oxalate ions (PubMed:11834742). Mediates the transport of bromide, iodide, nitrate, gluconate, thiocyanate and bicarbonate ions (By similarity). Its permeability towards bicarbonate is weak and increases when pH is above 7 (By similarity). Mediates thiocyanate transport in retinal pigment epithelium cells (By similarity). Mediates iodide transport in the thyroid gland, playing an important role in the synthesis of thyroid hormones and the maintenance of thyroid function (PubMed:31372509). Although it is an anion channel, according to PubMed:12736153 and PubMed:32119864 it has been shown to exhibit chloride-bicarbonate exchanger activity. {ECO:0000250|UniProtKB:Q8R2Z3, ECO:0000269|PubMed:11834742, ECO:0000269|PubMed:12736153, ECO:0000269|PubMed:31372509, ECO:0000269|PubMed:32119864}.
uniprot
proteins
mass_dalton
72213
uniprot
proteins
protein_family
SLC26A/SulP transporter (TC 2.A.53) family
uniprot
proteins
pubmed
11829495
uniprot
proteins
pubmed
11834742
uniprot
proteins
pubmed
12736153
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15956810
uniprot
proteins
pubmed
16524946
uniprot
proteins
pubmed
17504921
uniprot
proteins
pubmed
30333321
uniprot
proteins
pubmed
31372509
uniprot
proteins
pubmed
32119864
uniprot
proteins
pubmed
32486989
uniprot
proteins
sequence_length
656
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16524946, ECO:0000269|PubMed:30333321, ECO:0000269|PubMed:32119864}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q8R2Z3}; Multi-pass membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000269|PubMed:16524946}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:31372509}; Multi-pass membrane protein {ECO:0000255}. Lateral cell membrane {ECO:0000269|PubMed:31372509}; Multi-pass membrane protein {ECO:0000255}. Note=Expressed in the cytoplasm in recycling endosomes of medullary collecting duct cells and in acid-secreting gastric parietal cells. Targeted to the basolateral membrane in hypertonicity and potassium depletion. {ECO:0000269|PubMed:16524946}.
uniprot
proteins
transmembrane_region
TRANSMEM 76..96; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 145..165; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 167..187; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 203..223; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 228..248; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 255..275; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 307..327; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 344..364; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 384..404; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 405..425; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 449..469; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins