Metrnl
entrez
210029
canonical
uniprot
Q8VE43
canonical
ensembl
ENSMUSG00000039208
resolver
ensp
ENSMUSP00000038126
resolver
genesymbol
Metrnl
resolver
uniprot
Q8R1J2
resolver
uniprot_entry
METRL_MOUSE
resolver
uniprot_sec
Q8R1J2
resolver
amino_acid_sequence
MRGAVWAARRRAGQQWPRSPGPGPGPPPPPPLLLLLLLLLGGASAQYSSDLCSWKGSGLTREARSKEVEQVYLRCSAGSVEWMYPTGALIVNLRPNTFSPAQNLTVCIKPFRDSSGANIYLEKTGELRLLVRDIRGEPGQVQCFSLEQGGLFVEATPQQDISRRTTGFQYELMSGQRGLDLHVLSAPCRPCSDTEVLLAICTSDFVVRGFIEDVTHVPEQQVSVIYLRVNRLHRQKSRVFQPAPEDSGHWLGHVTTLLQCGVRPGHGEFLFTGHVHFGEAQLGCAPRFSDFQRMYRKAEEMGINPCEINME
uniprot
proteins
function
FUNCTION: Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures. {ECO:0000269|PubMed:24906147}.
uniprot
proteins
mass_dalton
34530
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:24393292}.
uniprot
proteins
protein_family
Meteorin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
24393292
uniprot
proteins
pubmed
24906147
uniprot
proteins
sequence_length
311
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24393292, ECO:0000269|PubMed:24906147}.
uniprot
proteins