Slc25a25
entrez
246771
canonical
uniprot
Q8K3P6
canonical
ensembl
ENSRNOG00000014338
resolver
ensp
ENSRNOP00000020206
resolver
ensp
ENSRNOP00000087701
resolver
ensp
ENSRNOP00000091438
resolver
ensp
ENSRNOP00000092861
resolver
ensp
ENSRNOP00000093449
resolver
enst
ENSRNOT00000020206
resolver
enst
ENSRNOT00000099400
resolver
enst
ENSRNOT00000104155
resolver
enst
ENSRNOT00000107630
resolver
enst
ENSRNOT00000115249
resolver
genesymbol
Slc25a25
resolver
genesymbol_syn
Mcsc
resolver
genesymbol_syn
Pcscl
resolver
genesymbol_syn
Scamc2
resolver
uniprot
A0A8I6AFK8
resolver
uniprot
A0A8I6AHU5
resolver
uniprot
A0A8I6ALC5
resolver
uniprot
A0A8I6GFE3
resolver
uniprot
A0A8L2QB89
resolver
uniprot_entry
A0A8I6AFK8_RAT
resolver
uniprot_entry
A0A8I6AHU5_RAT
resolver
uniprot_entry
A0A8I6ALC5_RAT
resolver
uniprot_entry
A0A8I6GFE3_RAT
resolver
uniprot_entry
A0A8L2QB89_RAT
resolver
uniprot_entry
SCMC2_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by an increase in cytosolic calcium levels that induces a conformational change of the N-terminal regulatory domain, uncapping the channel and allowing transport. {ECO:0000250|UniProtKB:Q6NUK1}.
uniprot
proteins
amino_acid_sequence
MLCLCLYVPIAGEAQTEFQYFESKGLPTELKSIFKLSVFIPSQEFSTYRQWKQKIVQAGDKDLDGQLDFEEFVHYLQDHEKKLRLVFKSLDKKNDGRIDAQEIMQSLRDLGVKISEQQAEKILKSMDKNGTMTIDWNEWRDYHLLHPVENIPEIILYWKHSTIFDVGENLTVPDEFTVEERQTGMWWRHLVAGGGAGAVSRTCTAPLDRLKVLMQVHASRSNNMCIIGGFTQMIREGGAKSLWRGNGINVLKIAPESAIKFMAYEQMKRLVGSDQETLRIHERLVAGSLAGAIAQSSIYPMEVLKTRMALRKTGQYSGMLDCAKRILAKEGVAAFYKGYIPNMLGIIPYAGIDLAVYETLKNTWLQRYAVNSADPGVFVLLACGTISSTCGQLASYPLALVRTRMQAQASIEGAPEVTMSSLFKQILRTEGAFGLYRGLAPNFMKVIPAVSISYVVYENLKITLGVQSR
uniprot
proteins
function
FUNCTION: Electroneutral antiporter that most probably mediates the transport of adenyl nucleotides through the inner mitochondrial membrane. Has calcium-dependent ATP-magnesium/inorganic phosphate antiporter. Could have a broader specificity for adenyl nucleotides. By regulating the mitochondrial matrix adenyl nucleotide pool, could adapt to changing cellular energetic demands and indirectly regulate adenyl nucleotide-dependent metabolic pathways. Acts downstream of Ca(2+)-permeable cation channel PKD2/TRPP2 and it is likely that PKD2-mediated Ca(2+) signaling activates SLC25A25 antiporter activity. Required for left-right pattern specification. {ECO:0000250|UniProtKB:A2ASZ8, ECO:0000250|UniProtKB:Q6KCM7, ECO:0000250|UniProtKB:Q6NUK1}.
uniprot
proteins
mass_dalton
52695
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
12645546
uniprot
proteins
pubmed
15054102
uniprot
proteins
sequence_length
469
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:12645546, ECO:0000305|PubMed:15054102}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 190..207; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 245..264; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 288..301; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 338..357; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 381..398; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 438..457; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins