Kcnt2
entrez
240776
canonical
uniprot
D3Z649
canonical
ensembl
ENSMUSG00000052726
resolver
ensp
ENSMUSP00000112887
resolver
ensp
ENSMUSP00000113333
resolver
ensp
ENSMUSP00000113535
resolver
ensp
ENSMUSP00000302940
resolver
ensp
ENSMUSP00000302941
resolver
ensp
ENSMUSP00000302946
resolver
enst
ENSMUST00000119786
resolver
genesymbol
Kcnt2
resolver
genesymbol_syn
Slick
resolver
genesymbol_syn
Slo2.2
resolver
uniprot
D3YTU6
resolver
uniprot
D3Z592
resolver
uniprot_entry
D3Z592_MOUSE
resolver
uniprot_entry
KCNT2_MOUSE
resolver
uniprot_sec
D3YTU6
resolver
activity_regulation
ACTIVITY REGULATION: Are normally in a closed state unless activated by an increase in intracellular Na(+) and Cl(-). Inhibited upon stimulation of G protein-coupled receptors, such as CHRM1 and GRM1. There is conflicting data about the effect of ATP on KNCT2 channels activity. Intracellular ATP was initially report to inhibit the channel activity. However, others studies conclude that KNCT2 channels are not inhibited by intracellular ATP. {ECO:0000250|UniProtKB:Q6UVM3, ECO:0000250|UniProtKB:Q6UVM4}.
uniprot
proteins
amino_acid_sequence
MVDLESEVPPLPPRYRFRDLLLGDQGWQNDDRVQVEFYMNENTFKERLKLFFIKNQRSSLRIRLFNFSLKLLSCLLYIIRVLLEKPSQGSEWSHIFWVNRSLPLWGLQVSVALISLFETILLGYLSYKGNIWEQILRIPFILEIINAVPFIISIFWPTLRNLFVPVFLNCWLAKHALENMINDLHRAIQRTQSAMFNQVLILISTLLCLIFTCICGIQHLERIGKKLNLFDSLYFCIVTFSTVGFGDVTPETWSSKLFVVAMICVALVVLPIQFEQLAYLWMERQKSGGNYSRHRAQTEKHVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPMWSQRVIYLQGSALKDQDLLRAKMDNAEACFILSSRCEVDRTSSDHQTILRAWAVKDFAPNCPLYVQILKPENKFHIKFADHVVCEEEFKYAMLALNCICPATSTLITLLVHTSRGQEGQQSPEQWQKTYGRCSGNEVYHIVLEESTFFAEYEGKSFTYASFHAHKKFGVCLVGVRREDNKNILLNPGPRYIMNASDICFYINITKEENSAFKNQDQQRKSNVSRSFYHGPSRLPVHSIIASMGTVAIDLQDTSCRATSGPTLALPSEGGKELRRPSIAPVLEVADTSSIQTCDLLSDQSEDETTPDEETSSNLEYAKGYPPYSPYIGSSPTFCHLLQEKVPFCCLRLDKSCQHNYYEDAKAYGFKNKLIIVAAETAGNGLYNFIVPLRAYYRPKKELNPIVLLLDNPPDMHFLDAICWFPMVYYMVGSIDNLDDLLRCGVTFAANMVVVDKESTMSAEEDYMADAKTIVNVQTLFRLFSSLSIITELTHPANMRFMQFRAKDCYSLALSKLEKKERERGSNLAFMFRLPFAAGRVFSISMLDTLLYQSFVKDYMISITRLLLGLDTIPGSGFLCSMKITEDDLWIRTYARLYQKLCSSTGDVPIGIYRTESQKLTTSESQISISVEEWEDTKDVKDPGHHRSLHRNSTSSDQSDHPLLRRKSMQWARRLSRKGPKHSGKTAEKITQQRLNLYRRSERQELAELVKNRMKHLGLSTVGYDEMNDHQSTLSYILINPSPDTRLELNDVVYLIRPDPLSYLPNSEPSRKNSICNAAVQDSREETQL
uniprot
proteins
function
FUNCTION: Sodium-activated and chloride-activated potassium channel. Produces rapidly activating outward rectifier K(+) currents (By similarity). Contributes to regulate neuronal excitability (PubMed:28943756). {ECO:0000250|UniProtKB:Q6UVM3, ECO:0000269|PubMed:28943756}.
uniprot
proteins
mass_dalton
130350
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain inhibits channel activity. {ECO:0000250|UniProtKB:Q6UVM3}.
uniprot
proteins
protein_family
Calcium-activated (TC 1.A.1.3) subfamily
uniprot
proteins
protein_family
KCa4.2/KCNT2 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
28943756
uniprot
proteins
pubmed
29124216
uniprot
proteins
sequence_length
1135
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:29124216}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 64..84; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 102..122; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 138..158; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 165..185; /note="Helical; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 199..219; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 257..277; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins