Sv2b
entrez
117556
canonical
uniprot
Q63564
canonical
ensembl
ENSRNOG00000011160
resolver
ensp
ENSRNOP00000083518
resolver
enst
ENSRNOT00000015084
resolver
genesymbol
Sv2b
resolver
genesymbol_syn
Sv2bb
resolver
uniprot
A0A8I5ZWR6
resolver
uniprot_entry
A0A8I5ZWR6_RAT
resolver
uniprot_entry
SV2B_RAT
resolver
amino_acid_sequence
MDDYRYRDNYEGYAPNDGYYRGNEQNPEEDAQSDVTEGHDEEDEIYEGEYQGIPHPDDVKSKQTKMAPSRADGLRGQADLMAERMEDEEQLAHQYETIIDECGHGRFQWTLFFVLVLALMADGVEVFVVSFALPSAEKDMCLSSSKKGMLGLIVYLGMMAGAFILGGLADKLGRKKVLSMSLAINASFASLSSFVQGYGAFLFCRLISGIGIGGSLPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGIYASAMAWSIIPHYGWGFSMGTNYHFHSWRVFVIVCALPATVSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDTNMRAKGTPEKVFTVSHIKTPKQMDEFIEIQSSTGTWYQRWLVRFMTIFKQVWDNALYCVMGPYRMNTLILAVVWFTMALSYYGLTVWFPDMIRYFQDEEYKSKMKVFFGEHVHGATINFTMENQIHQHGKLVNDKFIKMYFKHVLFEDTFFDKCYFEDVTSTDTYFKNCTIESTTFYNTDLYKHKFIDCRFINSTFLEQKEGCHMDFEEDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGRLKMIGGSMLISAVCCFFLFFGNSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNQRATAFGILNGLCKLGAILGNTIFASFVGITKVVPILLAAASLVGGGLVALRLPETREQVLM
uniprot
proteins
function
FUNCTION: Probably plays a role in the control of regulated secretion in neural and endocrine cells. {ECO:0000250}.; FUNCTION: (Microbial infection) Receptor for C.botulinum neurotoxin type A (BoNT/A, botA); the toxin binds via extracellular loop 4 (PubMed:16543415). Restores uptake of BoNT/A in mouse and rat cells that are deleted for SV2 receptor (PubMed:16543415, PubMed:18815274). Glycosylation of SV2B is not essential for receptor activity, but enhances the interaction (PubMed:18815274, PubMed:19650874). Also serves as a receptor for the closely related C.botulinum neurotoxin type A2; glycosylation is not essential but enhances the interaction (PubMed:29649119). {ECO:0000269|PubMed:16543415, ECO:0000269|PubMed:18815274, ECO:0000269|PubMed:19650874, ECO:0000269|PubMed:29649119}.; FUNCTION: (Microbial infection) Possible receptor for C.botulinum neurotoxin type D (BoNT/D, botD); BoNT/D does not bind to extracellular loop 4 as do BoNT/A and BoNT/E (PubMed:21483489). Another group does not find a convincing interaction with SV2 (PubMed:21632541). {ECO:0000269|PubMed:21483489, ECO:0000269|PubMed:21632541}.; FUNCTION: (Microbial infection) Receptor for C.botulinum neurotoxin type E (BoNT/E); the toxin probably binds via extracellular loop 4 (PubMed:18815274). Restores uptake of BoNT/E in mouse cells that are deleted for SV2 receptor (PubMed:18815274). Glycosylation of SV2B is not essential for receptor activity, but enhances the interaction (PubMed:19650874). {ECO:0000269|PubMed:18815274, ECO:0000269|PubMed:19650874}.; FUNCTION: (Microbial infection) Receptor for C.botulinum neurotoxin type F (BoNT/F); binding requires glycosylation of this protein (PubMed:19476346, PubMed:19650874). {ECO:0000269|PubMed:19650874, ECO:0000305|PubMed:19476346}.
uniprot
proteins
mass_dalton
77502
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:9801366, ECO:0000305|PubMed:29649119}.; PTM: The N-terminal cytoplasmic domain is phosphorylated by CK1. {ECO:0000269|PubMed:10747945}.
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
pubmed
10625067
uniprot
proteins
pubmed
10747945
uniprot
proteins
pubmed
11741278
uniprot
proteins
pubmed
12754292
uniprot
proteins
pubmed
15866046
uniprot
proteins
pubmed
16306227
uniprot
proteins
pubmed
16543415
uniprot
proteins
pubmed
18815274
uniprot
proteins
pubmed
19476346
uniprot
proteins
pubmed
19650874
uniprot
proteins
pubmed
21483489
uniprot
proteins
pubmed
21632541
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
29649119
uniprot
proteins
pubmed
7681585
uniprot
proteins
pubmed
9648885
uniprot
proteins
pubmed
9801366
uniprot
proteins
sequence_length
683
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:16306227, ECO:0000269|PubMed:7681585}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:12754292}. Note=Associated with synaptic-like microvesicles but not with insulin-containing vesicles in insulin-secreting cells of the pancreas (PubMed:16306227). Localizes to microvesicles in the pinealocytes. Localizes to the acrosome in spermatids (PubMed:12754292). {ECO:0000269|PubMed:12754292, ECO:0000269|PubMed:16306227}.
uniprot
proteins
transmembrane_region
TRANSMEM 111..131; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 149..169; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 183..203; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 206..226; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 238..258; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 278..298; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 391..411; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 536..556; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 566..586; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 593..613; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 627..649; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 654..672; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins