P2rx1
entrez
18436
canonical
uniprot
P51576
canonical
ensembl
ENSMUSG00000020787
resolver
ensp
ENSMUSP00000021141
resolver
ensp
ENSMUSP00000165718
resolver
enst
ENSMUST00000021141
resolver
genesymbol
P2rx1
resolver
uniprot
Q5SRU4
resolver
uniprot_entry
P2RX1_MOUSE
resolver
uniprot_sec
Q5SRU4
resolver
activity_regulation
ACTIVITY REGULATION: Activated by low concentrations of ATP (<1 uM). Undergoes rapid desensitization. Sensitives to the ATP agonist:alpha/beta-methylene-ATP. Modulated by cholesterol. {ECO:0000250|UniProtKB:P51575}.
uniprot
proteins
amino_acid_sequence
MARRLQDELSAFFFEYDTPRMVLVRNKKVGVIFRLIQLVVLVYVIGWVFVYEKGYQTSSGLISSVSVKLKGLAVTQLQGLGPQVWDVADYVFPAHGDSSFVVMTNFIMTPQQAQGHCAENPEGGICQDDSGCTPGKAERKAQGIRTGNCVPFNGTVKTCEIFGWCPVEVDDKIPSPALLHEAENFTLFIKNSISFPRFKVNRRNLVEEVNGTYMKKCLYHKILHPLCPVFSLGYVVRESGQDFRSLAEKGGVVGITIDWECDLDWHVRHCKPIYQFHGLYGEKNLSPGFNFRFARHFVQNGTNRRHLFKVFGIRFDILVDGKAGKFDIIPTMTTIGSGIGIFGVATVLCDLLLLHILPKRHYYKQKKFKYAEDMGPGEGERDPAATSSTLGLQENMRTS
uniprot
proteins
function
FUNCTION: ATP-gated nonselective transmembrane cation channel permeable to potassium, sodium and with relatively high calcium permeability (By similarity). Furthermore, CTP functions as a weak affinity agonist for P2RX1 (By similarity). Plays a role in male fertility, bladder contraction and platelet aggregation (PubMed:10638758, PubMed:11090125, PubMed:19635923, PubMed:25150292). Specifically, plays an important role in neurogenic contraction of smooth muscle of the vas deferens, and therefore is essential for normal male reproductive function (PubMed:10638758). In addition, contributes to smooth muscle contractions of the urinary bladder (PubMed:11090125). On platelets, contributes to platelet activation and aggregation and thereby, also to thrombosis (PubMed:25150292). On neutrophils, it is involved in chemotaxis and in mitigating the activation of circulating cells (PubMed:19635923). {ECO:0000250|UniProtKB:P51575, ECO:0000269|PubMed:10638758, ECO:0000269|PubMed:11090125, ECO:0000269|PubMed:19635923, ECO:0000269|PubMed:25150292}.
uniprot
proteins
mass_dalton
44851
uniprot
proteins
protein_family
P2X receptor family
uniprot
proteins
pubmed
10638758
uniprot
proteins
pubmed
11090125
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19635923
uniprot
proteins
pubmed
25150292
uniprot
proteins
pubmed
8834001
uniprot
proteins
sequence_length
399
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P51575}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P56373}. Note=Detected at plasma membrane lipid rafts. {ECO:0000250|UniProtKB:P51575}.
uniprot
proteins
transmembrane_region
TRANSMEM 29..50; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 339..358; /note="Helical; Name=2"; /evidence="ECO:0000255
uniprot
proteins