IFIT2
entrez
3433
canonical
uniprot
P09913
canonical
ensembl
ENSG00000119922
resolver
ensp
ENSP00000360891
resolver
ensp
ENSP00000490935
resolver
ensp
ENSP00000505033
resolver
ensp
ENSP00000506255
resolver
enst
ENST00000371826
resolver
enst
ENST00000638108
resolver
enst
ENST00000680809
resolver
enst
ENST00000680954
resolver
genesymbol
IFIT2
resolver
genesymbol_syn
CIG-42
resolver
genesymbol_syn
G10P2
resolver
genesymbol_syn
IFI54
resolver
genesymbol_syn
ISG54
resolver
hgnc
HGNC:5409
resolver
uniprot
Q05DN2
resolver
uniprot
Q5T767
resolver
uniprot_entry
IFIT2_HUMAN
resolver
uniprot_entry
Q05DN2_HUMAN
resolver
uniprot_sec
Q5T767
resolver
amino_acid_sequence
MSENNKNSLESSLRQLKCHFTWNLMEGENSLDDFEDKVFYRTEFQNREFKATMCNLLAYLKHLKGQNEAALECLRKAEELIQQEHADQAEIRSLVTWGNYAWVYYHMGRLSDVQIYVDKVKHVCEKFSSPYRIESPELDCEEGWTRLKCGGNQNERAKVCFEKALEKKPKNPEFTSGLAIASYRLDNWPPSQNAIDPLRQAIRLNPDNQYLKVLLALKLHKMREEGEEEGEGEKLVEEALEKAPGVTDVLRSAAKFYRRKDEPDKAIELLKKALEYIPNNAYLHCQIGCCYRAKVFQVMNLRENGMYGKRKLLELIGHAVAHLKKADEANDNLFRVCSILASLHALADQYEDAEYYFQKEFSKELTPVAKQLLHLRYGNFQLYQMKCEDKAIHHFIEGVKINQKSREKEKMKDKLQKIAKMRLSKNGADSEALHVLAFLQELNEKMQQADEDSERGLESGSLIPSASSWNGE
uniprot
proteins
function
FUNCTION: IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2'-O-methylation of the 5' cap. The ribose 2'-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2'-O-methylase for their mRNAs or by stealing host cap containing the 2'-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5' triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis. {ECO:0000269|PubMed:21190939}.
uniprot
proteins
mass_dalton
54632
uniprot
proteins
mutagenesis
MUTAGEN 184; /note="R->E: Abolishes RNA-binding."; /evidence="ECO:0000269|PubMed:22825553"; MUTAGEN 255; /note="K->E: Significantly impairs RNA-binding; when associated with Glu-259."; /evidence="ECO:0000269|PubMed:22825553"; MUTAGEN 259; /note="R->E: Significantly impairs RNA-binding; when associated with Glu-255."; /evidence="ECO:0000269|PubMed:22825553"; MUTAGEN 292; /note="R->E: Abolishes RNA-binding."; /evidence="ECO:0000269|PubMed:22825553"; MUTAGEN 410; /note="K->E: Abolishes RNA-binding."; /evidence="ECO:0000269|PubMed:22825553
uniprot
proteins
protein_family
IFIT family
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
16973618
uniprot
proteins
pubmed
19416887
uniprot
proteins
pubmed
20950130
uniprot
proteins
pubmed
21190939
uniprot
proteins
pubmed
21642987
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
22825553
uniprot
proteins
pubmed
2454816
uniprot
proteins
pubmed
3360121
uniprot
proteins
pubmed
3466167
uniprot
proteins
sequence_length
472
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21190939}. Endoplasmic reticulum {ECO:0000269|PubMed:21190939}.
uniprot
proteins