Cox8a
entrez
171335
canonical
uniprot
P80433
canonical
ensembl
ENSRNOG00000073321
resolver
ensembl
ENSRNOG00055022976
resolver
ensembl
ENSRNOG00060032943
resolver
ensembl
ENSRNOG00065030827
resolver
ensp
ENSRNOP00000109211
resolver
ensp
ENSRNOP00055032058
resolver
ensp
ENSRNOP00060047206
resolver
ensp
ENSRNOP00065043639
resolver
enst
ENSRNOT00000141807
resolver
enst
ENSRNOT00055039484
resolver
enst
ENSRNOT00060057126
resolver
enst
ENSRNOT00065053130
resolver
genesymbol
Cox8a
resolver
genesymbol_syn
COX-VIII
resolver
genesymbol_syn
Cox8
resolver
genesymbol_syn
Cox8l
resolver
uniprot
A0JMZ9
resolver
uniprot
Q64576
resolver
uniprot_entry
COX8A_RAT
resolver
uniprot_entry
Q64576_RAT
resolver
uniprot_sec
A0JMZ9
resolver
amino_acid_sequence
MSSLTPLLLRSLTGPARRLMVPRAQVHSKPPREQLGVLDITIGLTSCFVCCLLPAGWVLSHLESYKKRE
uniprot
proteins
function
FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P10175}.
uniprot
proteins
mass_dalton
7672
uniprot
proteins
pathway_participation
PATHWAY: Energy metabolism; oxidative phosphorylation. {ECO:0000250|UniProtKB:P10175}.
uniprot
proteins
post_translational_modification
PTM: In response to mitochondrial stress, the precursor protein is ubiquitinated by the SIFI complex in the cytoplasm before mitochondrial import, leading to its degradation. Within the SIFI complex, UBR4 initiates ubiquitin chain that are further elongated or branched by KCMF1. {ECO:0000250|UniProtKB:P10176}.
uniprot
proteins
protein_family
Cytochrome c oxidase VIII family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2822403
uniprot
proteins
pubmed
7601105
uniprot
proteins
sequence_length
69
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P10176}; Single-pass membrane protein {ECO:0000250|UniProtKB:P10176}.
uniprot
proteins
transmembrane_region
TRANSMEM 37..60; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P10175
uniprot
proteins