E4F1
entrez
1877
canonical
uniprot
Q66K89
canonical
ensembl
ENSG00000167967
resolver
ensp
ENSP00000301727
resolver
ensp
ENSP00000456760
resolver
ensp
ENSP00000457672
resolver
ensp
ENSP00000532934
resolver
ensp
ENSP00000532936
resolver
ensp
ENSP00000532940
resolver
ensp
ENSP00000697695
resolver
ensp
ENSP00000697703
resolver
enst
ENST00000301727
resolver
enst
ENST00000564139
resolver
enst
ENST00000565090
resolver
genesymbol
E4F1
resolver
genesymbol_syn
E4F
resolver
hgnc
HGNC:3121
resolver
uniprot
A8K2R4
resolver
uniprot
H3BSL4
resolver
uniprot
H3BUJ7
resolver
uniprot
O00146
resolver
uniprot_entry
E4F1_HUMAN
resolver
uniprot_entry
H3BSL4_HUMAN
resolver
uniprot_entry
H3BUJ7_HUMAN
resolver
uniprot_sec
A8K2R4
resolver
uniprot_sec
O00146
resolver
amino_acid_sequence
MEGAMAVRVTAAHTAEAQAEAGREAGEGAVAAVAAALAPSGFLGLPAPFSEEDEDDVHRCGRCQAEFTALEDFVQHKIQKACQRAPPEALPATPATTALLGQEVVPAAPGPEEPITVAHIVVEAASLAADISHASDLVGGGHIKEVIVAAEAELGDGEMAEAPGSPRQQGLGLAGEGEQAQVKLLVNKDGRYVCALCHKTFKTGSILKAHMVTHSSRKDHECKLCGASFRTKGSLIRHHRRHTDERPYKCSKCGKSFRESGALTRHLKSLTPCTEKIRFSVSKDVVVSKEDARAGSGAGAAGLGTATSSVTGEPIETSPVIHLVTDAKGTVIHEVHVQMQELSLGMKALAPEPPVSQELPCSSEGSRENLLHQAMQNSGIVLERAAGEEGALEPAPAAGSSPQPLAVAAPQLPVLEVQPLETQVASEASAVPRTHPCPQCSETFPTAATLEAHKRGHTGPRPFACAQCGKAFPKAYLLKKHQEVHVRERRFRCGDCGKLYKTIAHVRGHRRVHSDERPYPCPKCGKRYKTKNAQQVHFRTHLEEKPHVCQFCSRGFREKGSLVRHVRHHTGEKPFKCYKCGRGFAEHGTLNRHLRTKGGCLLEVEELLVSEDSPAAATTVLTEDPHTVLVEFSSVVADTQEYIIEATADDAETSEATEIIEGTQTEVDSHIMKVVQQIVHQASAGHQIIVQNVTMDEETALGPEAAAADTITIATPESLTEQVAMTLASAISEGTVLAARAGTSGTEQATVTMVSSEDIEILEHAGELVIASPEGQLEVQTVIV
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription.; FUNCTION: Identified as a cellular target of the adenoviral oncoprotein E1A, it is required for both transcriptional activation and repression of viral genes.
uniprot
proteins
mass_dalton
83496
uniprot
proteins
mutagenesis
MUTAGEN 194; /note="C->S: Increases DNA-binding; when associated with S-197."; /evidence="ECO:0000269|PubMed:9512539"; MUTAGEN 197; /note="C->S: Increases DNA-binding; when associated with S-194."; /evidence="ECO:0000269|PubMed:9512539"; MUTAGEN 210; /note="H->A: Alters DNA-binding."; /evidence="ECO:0000269|PubMed:9512539"; MUTAGEN 237; /note="R->L: Alters DNA-binding; when associated with N-238."; /evidence="ECO:0000269|PubMed:9512539"; MUTAGEN 238; /note="H->N: Alters DNA-binding; when associated with L-237."; /evidence="ECO:0000269|PubMed:9512539"; MUTAGEN 249; /note="K->M: Alters DNA-binding; when associated with S-250."; /evidence="ECO:0000269|PubMed:9512539"; MUTAGEN 250; /note="C->S: Alters DNA-binding; when associated with M-249."; /evidence="ECO:0000269|PubMed:9512539
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Proteolytic cleavage produces a 50 kDa N-terminal peptide (p50E4F) which has a DNA-binding activity and activates transcription in presence of the adenoviral E1A protein. The major full-length protein (p120E4F) functions as a repressor of transcription. {ECO:0000269|PubMed:9121437}.; PTM: Phosphorylated; p120E4F and p50E4F are both phosphorylated. Phosphorylation is cell cycle-dependent and differentially regulates DNA-binding activity and function of both forms. {ECO:0000269|PubMed:9121437, ECO:0000269|PubMed:9512539}.; PTM: May be sumoylated by UBE2I upon interaction with CDKN2A. {ECO:0000269|PubMed:15876874}.
uniprot
proteins
pubmed
10373523
uniprot
proteins
pubmed
10644996
uniprot
proteins
pubmed
10869426
uniprot
proteins
pubmed
11283272
uniprot
proteins
pubmed
12446718
uniprot
proteins
pubmed
12730668
uniprot
proteins
pubmed
14645522
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14729613
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15579445
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
15805267
uniprot
proteins
pubmed
15876874
uniprot
proteins
pubmed
16112766
uniprot
proteins
pubmed
16652157
uniprot
proteins
pubmed
16882984
uniprot
proteins
pubmed
17110336
uniprot
proteins
pubmed
17557114
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
9121437
uniprot
proteins
pubmed
9418893
uniprot
proteins
pubmed
9512539
uniprot
proteins
pubmed
9530632
uniprot
proteins
sequence_length
784
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm. Cytoplasm. Note=A small fraction is detected in the cytoplasm. Excluded from the nucleolus where it is targeted upon CDKN2A overexpression. Localizes to the mitotic spindle during embryogenesis. {ECO:0000250}.
uniprot
proteins