Gcm1
entrez
14531
canonical
uniprot
P70348
canonical
ensembl
ENSMUSG00000023333
resolver
ensp
ENSMUSP00000024104
resolver
enst
ENSMUST00000024104
resolver
genesymbol
Gcm1
resolver
genesymbol_syn
Gcma
resolver
uniprot
O09103
resolver
uniprot
Q3UQD1
resolver
uniprot_entry
GCM1_MOUSE
resolver
uniprot_entry
Q3UQD1_MOUSE
resolver
uniprot_sec
O09103
resolver
amino_acid_sequence
MELDDFDPEDKEILSWDINDVKLPQNVKTTDWFQEWPDSYVKHIYSSDDRNAQRHLSSWAMRNTNNHNSRILKKSCLGVVVCSRDCSTEEGRKIYLRPAICDKARQKQQRKSCPNCNGPLKLIPCRGHGGFPVTNFWRHDGRFIFFQSKGEHDHPRPETKLEAEARRAMKKVHMASASNSLRMKGRPAAKALPAEIPSQGSLPLTWSFQEGVQLPGTYSTPLIANAPQQNSLNDCLSFPKSYDLGGSTELEDPTSTLDSMKFYERCKFSSSRIYGSEEQFQPPVPGTYGDYEDLQTWNKNVALGRNPSDDIYYPAYPLPVASWPYDYFPSQNSLEHLPQQVPSEPPAAQPGCHPLWSNPGGEPYEEKVSVDLSSYVPSLTYHPPQQDPFLLTYGSPTQQQHALPGKSNRWDFDEEMACMGLDHFNNEMLLNFCSLR
uniprot
proteins
function
FUNCTION: Transcription factor that is necessary for placental development (PubMed:8962155). Involved in the control of expression of placental growth factor (PGF) and other placenta-specific genes. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer. Binds to the SYDE1 promoter. Has a central role in mediating the differentiation of trophoblast cells along both the villous and extravillous pathways in placental development (By similarity). {ECO:0000250|UniProtKB:Q9NP62, ECO:0000269|PubMed:8962155}.
uniprot
proteins
mass_dalton
49589
uniprot
proteins
mutagenesis
MUTAGEN 63; /note="N->A: No effect on DNA binding."; /evidence="ECO:0000269|PubMed:12682016"; MUTAGEN 63; /note="N->Q: Slight decrease of DNA binding."; /evidence="ECO:0000269|PubMed:12682016"; MUTAGEN 65; /note="N->A: Strong decrease of DNA binding."; /evidence="ECO:0000269|PubMed:12682016"; MUTAGEN 65; /note="N->D: Loss of DNA binding."; /evidence="ECO:0000269|PubMed:12682016"; MUTAGEN 74; /note="K->A,L,M: Loss of DNA binding."; /evidence="ECO:0000269|PubMed:12682016"; MUTAGEN 76; /note="C->A: Loss of transcription activation."; /evidence="ECO:0000269|PubMed:12682016"; MUTAGEN 82; /note="C->A: Loss of transcription activation."; /evidence="ECO:0000269|PubMed:12682016"; MUTAGEN 113; /note="C->A: Loss of transcription activation."; /evidence="ECO:0000269|PubMed:12682016"; MUTAGEN 125; /note="C->A: Loss of transcription activation."; /evidence="ECO:0000269|PubMed:12682016"; MUTAGEN 152; /note="H->A: Loss of transcription activation."; /evidence="ECO:0000269|PubMed:12682016"; MUTAGEN 154; /note="H->A: Loss of transcription activation."; /evidence="ECO:0000269|PubMed:12682016
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated in the presence of UBE2D2 and FBXW2 (in vitro). {ECO:0000250}.
uniprot
proteins
pubmed
12682016
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8814290
uniprot
proteins
pubmed
8962155
uniprot
proteins
sequence_length
436
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00245}.
uniprot
proteins