Trim26
entrez
309586
canonical
uniprot
P62603
canonical
ensembl
ENSRNOG00000032930
resolver
ensembl
ENSRNOG00055009124
resolver
ensembl
ENSRNOG00060003444
resolver
ensembl
ENSRNOG00065028637
resolver
ensp
ENSRNOP00000001019
resolver
ensp
ENSRNOP00000098141
resolver
ensp
ENSRNOP00000098153
resolver
ensp
ENSRNOP00055012356
resolver
ensp
ENSRNOP00060004129
resolver
ensp
ENSRNOP00065040512
resolver
enst
ENSRNOT00000001019
resolver
enst
ENSRNOT00000120477
resolver
enst
ENSRNOT00000120493
resolver
enst
ENSRNOT00055015439
resolver
enst
ENSRNOT00060005662
resolver
enst
ENSRNOT00065049382
resolver
genesymbol
Trim26
resolver
genesymbol_syn
Znf173
resolver
uniprot
A0ABK0L3C0
resolver
uniprot
A0ABK0L9U8
resolver
uniprot
Q6MFZ0
resolver
uniprot_entry
A0ABK0L3C0_RAT
resolver
uniprot_entry
A0ABK0L9U8_RAT
resolver
uniprot_entry
TRI26_RAT
resolver
uniprot_sec
Q6MFZ0
resolver
amino_acid_sequence
MAVSAPLRSLEEEVTCSICLDYLRDPVTIDCGHVFCRSCTSDIRPISGNRPVCPLCKKPFKKENIRPVWQLASLVENIERLKVDNGKQPGELAREPQDMKLCERHQEKLHYYCEDDGKLLCVMCRESREHRPHTAVLVEKAALPHREKILNHLNTLRRDRDKIQGFQAKGEADILAALTKLQEQRQYIVAEFKQGHQFLKKREQHLLDQLATLEQLLTEGREKFKTRGVSELDRLTLVISELEGKARQPAAELMQLSDRLSCLSLRYPRKKFWIGKAIPHMVKRKAGEFSDKLLSLQRGLRQFQGKLLRDLEYKTVSVTLDPQSASGYLQLSEDWKCITYTGQYQSDCLLPQQFDCEPGVLGSKGFTWGKVYWEVELEREGWSEDEEEGEEEEEGEEEEEDEEPGYGDRYEDWETDEEDESLGEEEEEEEEEEEEVQESCMVGVAKDSVKRKGNLSLRPEDGVWALRLSPSGIWANTSPEAQLFPVLRPRRVGIALDYEGGTVTFTNAESQELIYTFTTTFTRRLVPFLWLKWPEARLLLRP
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase which regulates the IFN-beta production and antiviral response downstream of various DNA-encoded pattern-recognition receptors (PRRs). Also plays a central role in determining the response to different forms of oxidative stress by controlling levels of DNA glycosylases NEIL1, NEIL3 and NTH1 that are involved in repair of damaged DNA. Promotes nuclear IRF3 ubiquitination and proteasomal degradation. Bridges together TBK1 and NEMO during the innate response to viral infection leading to the activation of TBK1. Positively regulates LPS-mediated inflammatory innate immune response by catalyzing the 'Lys-11'-linked polyubiquitination of TAB1 to enhance its activation and subsequent NF-kappa-B and MAPK signaling. In a manner independent of its catalytic activity, inhibits WWP2, a SOX2-directed E3 ubiquitin ligase, and thus protects SOX2 from polyubiquitination and proteasomal degradation. Ubiquitinates the histone acetyltransferase protein complex component PHF20 and thereby triggers its degradation in the nucleus after its recruitment by the histone demethylase KDM6B, serving as a scaffold protein. Upon induction by TGF-beta, ubiquitinates the TFIID component TAF7 for proteasomal degradation (By similarity). Induces ferroptosis by ubiquitinating SLC7A11, a critical protein for lipid reactive oxygen species (ROS) scavenging (By similarity). {ECO:0000250|UniProtKB:Q12899, ECO:0000250|UniProtKB:Q99PN3}.
uniprot
proteins
mass_dalton
62631
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinates upon viral infection. In turn, autoubiquitinated TRIM26 recruits NEMO and bridges TBK1-NEMO interaction. {ECO:0000250|UniProtKB:Q12899}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
15060004
uniprot
proteins
sequence_length
542
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q12899}. Nucleus {ECO:0000250|UniProtKB:Q12899}. Note=Viral infection mediates TRIM26 nuclear translocation. {ECO:0000250|UniProtKB:Q12899}.
uniprot
proteins