PRMT2
entrez
3275
canonical
uniprot
P55345
canonical
ensembl
ENSG00000160310
resolver
ensp
ENSP00000291705
resolver
ensp
ENSP00000335490
resolver
ensp
ENSP00000347906
resolver
ensp
ENSP00000380760
resolver
ensp
ENSP00000397266
resolver
ensp
ENSP00000407463
resolver
ensp
ENSP00000411984
resolver
ensp
ENSP00000559275
resolver
ensp
ENSP00000559297
resolver
ensp
ENSP00000723740
resolver
ensp
ENSP00000723760
resolver
ensp
ENSP00000782855
resolver
ensp
ENSP00000800288
resolver
genesymbol
PRMT2
resolver
genesymbol_syn
HMT1
resolver
genesymbol_syn
HRMT1L1
resolver
hgnc
HGNC:5186
resolver
uniprot
A0A0S2Z3N3
resolver
uniprot
B7U630
resolver
uniprot
B7U631
resolver
uniprot
B7U632
resolver
uniprot
P78350
resolver
uniprot
Q498Y5
resolver
uniprot
Q5U7D4
resolver
uniprot
Q6FHF0
resolver
uniprot
Q99781
resolver
uniprot
Q9BW15
resolver
uniprot
Q9UMC2
resolver
uniprot_entry
A0A0S2Z3N3_HUMAN
resolver
uniprot_entry
ANM2_HUMAN
resolver
uniprot_sec
B7U630
resolver
uniprot_sec
B7U631
resolver
uniprot_sec
B7U632
resolver
uniprot_sec
P78350
resolver
uniprot_sec
Q498Y5
resolver
uniprot_sec
Q5U7D4
resolver
uniprot_sec
Q6FHF0
resolver
uniprot_sec
Q99781
resolver
uniprot_sec
Q9BW15
resolver
uniprot_sec
Q9UMC2
resolver
amino_acid_sequence
MATSGDCPRSESQGEEPAECSEAGLLQEGVQPEEFVAIADYAATDETQLSFLRGEKILILRQTTADWWWGERAGCCGYIPANHVGKHVDEYDPEDTWQDEEYFGSYGTLKLHLEMLADQPRTTKYHSVILQNKESLTDKVILDVGCGTGIISLFCAHYARPRAVYAVEASEMAQHTGQLVLQNGFADIITVYQQKVEDVVLPEKVDVLVSEWMGTCLLFEFMIESILYARDAWLKEDGVIWPTMAALHLVPCSADKDYRSKVLFWDNAYEFNLSALKSLAVKEFFSKPKYNHILKPEDCLSEPCTILQLDMRTVQISDLETLRGELRFDIRKAGTLHGFTAWFSVHFQSLQEGQPPQVLSTGPFHPTTHWKQTLFMMDDPVPVHTGDVVTGSVVLQRNPVWRRHMSVALSWAVTSRQDPTSQKVGEKVFPIWR
uniprot
proteins
ec_number
2.1.1.319
uniprot
proteins
function
FUNCTION: Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4 (PubMed:19405910). Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation (PubMed:17587566). Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation (PubMed:12039952). Enhances PGR, PPARG, RARA-mediated transactivation (PubMed:12039952). May inhibit NF-kappa-B transcription and promote apoptosis (PubMed:16648481). Represses E2F1 transcriptional activity (in a RB1-dependent manner) (By similarity). May be involved in growth regulation (By similarity). Involved in PRMT2IP-mediated inhibition of the microglial inflammatory responses through suppression of NF-kappa-B signaling, thereby reducing the production of pro-inflammatory cytokines (PubMed:38892217). {ECO:0000250|UniProtKB:Q9R144, ECO:0000269|PubMed:12039952, ECO:0000269|PubMed:16648481, ECO:0000269|PubMed:17587566, ECO:0000269|PubMed:19405910, ECO:0000269|PubMed:38892217}.
uniprot
proteins
mass_dalton
49042
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
Protein arginine N-methyltransferase family
uniprot
proteins
pubmed
10830953
uniprot
proteins
pubmed
11513728
uniprot
proteins
pubmed
12039952
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16648481
uniprot
proteins
pubmed
17587566
uniprot
proteins
pubmed
17925405
uniprot
proteins
pubmed
19405910
uniprot
proteins
pubmed
21820040
uniprot
proteins
pubmed
22093364
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
38892217
uniprot
proteins
pubmed
9110174
uniprot
proteins
pubmed
9196002
uniprot
proteins
pubmed
9545638
uniprot
proteins
sequence_length
433
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:17587566, ECO:0000269|PubMed:38892217}. Nucleus {ECO:0000269|PubMed:11513728, ECO:0000269|PubMed:17587566, ECO:0000269|PubMed:22093364}. Note=Translocates from the cytoplasm to the nucleus, after hormone exposure (PubMed:17587566). Excluded from nucleolus (PubMed:22093364). {ECO:0000269|PubMed:17587566, ECO:0000269|PubMed:22093364}.; SUBCELLULAR LOCATION: [Isoform PRMT2Alpha]: Nucleus {ECO:0000269|PubMed:22093364}. Note=Excluded from nucleolus.; SUBCELLULAR LOCATION: [Isoform PRMT2Beta]: Cytoplasm {ECO:0000269|PubMed:22093364}. Nucleus {ECO:0000269|PubMed:22093364}. Nucleus, nucleolus {ECO:0000269|PubMed:22093364}.; SUBCELLULAR LOCATION: [Isoform PRMT2Gamma]: Nucleus {ECO:0000269|PubMed:22093364}. Note=Excluded from nucleolus.; SUBCELLULAR LOCATION: [Isoform PRMT2L2]: Cytoplasm {ECO:0000269|PubMed:21820040}. Nucleus {ECO:0000269|PubMed:21820040}. Note=Predominantly cytoplasmic.
uniprot
proteins