Cd69
entrez
12515
canonical
uniprot
P37217
canonical
ensembl
ENSMUSG00000030156
resolver
ensp
ENSMUSP00000032259
resolver
enst
ENSMUST00000032259
resolver
genesymbol
Cd69
resolver
uniprot
Q3U6A8
resolver
uniprot_entry
CD69_MOUSE
resolver
uniprot_entry
Q3U6A8_MOUSE
resolver
amino_acid_sequence
MDSENCSITENSSSHLERGQKDHGTSIHFEKHHEGSIQVSIPWAVLIVVLITSLIIALIALNVGKYNCPGLYEKLESSDHHVATCKNEWISYKRTCYFFSTTTKSWALAQRSCSEDAATLAVIDSEKDMTFLKRYSGELEHWIGLKNEANQTWKWANGKEFNSWFNLTGSGRCVSVNHKNVTAVDCEANFHWVCSKPSR
uniprot
proteins
function
FUNCTION: Transmembrane protein expressed mainly on T-cells resident in mucosa that plays an essential role in immune cell homeostasis. Rapidly expressed on the surface of platelets, T-lymphocytes and NK cells upon activation by various stimuli, such as antigen recognition or cytokine signaling, stimulates different signaling pathways in different cell types (PubMed:20696842, PubMed:38540778). Negatively regulates Th17 cell differentiation through its carbohydrate dependent interaction with galectin-1/LGALS1 present on immature dendritic cells (By similarity). Association of CD69 cytoplasmic tail with the JAK3/STAT5 signaling pathway regulates the transcription of RORgamma/RORC and, consequently, differentiation toward the Th17 lineage (PubMed:20696842). Also acts via the S100A8/S100A9 complex present on peripheral blood mononuclear cells to promote the conversion of naive CD4 T-cells into regulatory T-cells. Acts as an oxidized low-density lipoprotein (oxLDL) receptor in CD4 T-lymphocytes and negatively regulates the inflammatory response by inducing the expression of PDCD1 through the activation of NFAT. Participates in adipose tissue-derived mesenchymal stem cells (ASCs)-mediated protection against P.aeruginosa infection. Mechanistically, specifically recognizes P.aeruginosa to promote ERK1 activation, followed by granulocyte-macrophage colony-stimulating factor (GM-CSF) and other inflammatory cytokines secretion (By similarity). In eosinophils, induces IL-10 production through the ERK1/2 pathway (PubMed:38540778). Negatively regulates the chemotactic responses of effector lymphocytes and dendritic cells (DCs) to sphingosine 1 phosphate/S1P by acting as a S1PR1 receptor agonist and facilitating the internalization and degradation of the receptor (PubMed:16525420). {ECO:0000250|UniProtKB:Q07108, ECO:0000269|PubMed:16525420, ECO:0000269|PubMed:20696842, ECO:0000269|PubMed:38540778}.
uniprot
proteins
mass_dalton
22517
uniprot
proteins
post_translational_modification
PTM: Constitutive Ser/Thr phosphorylation in both mature thymocytes and activated T-lymphocytes. {ECO:0000250}.
uniprot
proteins
pubmed
16525420
uniprot
proteins
pubmed
20696842
uniprot
proteins
pubmed
38540778
uniprot
proteins
pubmed
8100776
uniprot
proteins
sequence_length
199
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:38540778}; Single-pass type II membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 41..61; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins