Nat1
entrez
17960
canonical
uniprot
P50294
canonical
ensembl
ENSMUSG00000025588
resolver
ensp
ENSMUSP00000026677
resolver
enst
ENSMUST00000026677
resolver
genesymbol
Nat1
resolver
genesymbol_syn
Aac1
resolver
uniprot
Q546L3
resolver
uniprot_entry
ARY1_MOUSE
resolver
uniprot_entry
Q546L3_MOUSE
resolver
amino_acid_sequence
MDIEAYFERIGYKNSVNKLDLATLTEVLQHQMRAVPFENLNMHCGEAMHLDLQDIFDHIVRKKRGGWCLQVNHLLYWALTKMGFETTMLGGYVYITPVSKYSSEMVHLLVQVTISDRKYIVDSAYGGSYQMWEPLELTSGKDQPQVPAIFLLTEENGTWYLDQIRREQYVPNEEFVNSDLLEKNKYRKIYSFTLEPRVIEDFEYVNSYLQTSPASVFVSTSFCSLQTSEGVHCLVGSTFTSRRFSYKDDVDLVEFKYVNEEEIEDVLKTAFGISLERKFVPKHGELVFTI
uniprot
proteins
ec_number
2.3.1.-
uniprot
proteins
ec_number
2.3.1.118
uniprot
proteins
ec_number
2.3.1.5
uniprot
proteins
function
FUNCTION: Xenobiotic-metabolizing enzyme that catalyzes both N-acetylation (usually detoxification) and O-acetylation (usually bioactivation) of a wide range of species-specific substrates including hydrazines, aromatic amine drugs and aromatic amine carcinogens (PubMed:1513324, PubMed:7545952). Isoniazid, 2-aminofluorene and anisidine are preferred substrates for NAT-1 (PubMed:1513324, PubMed:7545952). No activity with p-aminobenzoic acid (PABA) nor SMZ (PubMed:1513324, PubMed:7545952). Transfers an acetyl group from acetyl-coenzyme A to arylamine and N-hydroxyarylamine acceptor substrates (PubMed:1513324, PubMed:7545952). Can also transfer an N-acetyl group from an N-hydroxy acetylamine to either N-hydroxyarylamine or arylamine in the absence of acetyl-coenzyme A. Therefore, activates N-hydroxyarylamines to unstable acetoxy intermediates which decompose to electrophiles, bind to DNA, and lead to mutagenesis and carcinogenesis (By similarity). Plays a significant role in the bioactivation and detoxification of many drugs and carcinogens (PubMed:1513324, PubMed:7545952). {ECO:0000250|UniProtKB:P18440, ECO:0000269|PubMed:1513324, ECO:0000269|PubMed:7545952}.
uniprot
proteins
mass_dalton
33713
uniprot
proteins
protein_family
Arylamine N-acetyltransferase family
uniprot
proteins
pubmed
1513324
uniprot
proteins
pubmed
1875909
uniprot
proteins
pubmed
7545952
uniprot
proteins
sequence_length
290
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:1513324}.
uniprot
proteins