Il33
entrez
77125
canonical
uniprot
Q8BVZ5
canonical
ensembl
ENSMUSG00000024810
resolver
ensp
ENSMUSP00000025724
resolver
ensp
ENSMUSP00000113829
resolver
ensp
ENSMUSP00000289949
resolver
ensp
ENSMUSP00000289958
resolver
ensp
ENSMUSP00000289962
resolver
enst
ENSMUST00000025724
resolver
enst
ENSMUST00000120388
resolver
genesymbol
Il33
resolver
uniprot
Q2YEJ4
resolver
uniprot
Q3TQN0
resolver
uniprot
Q99L46
resolver
uniprot_entry
IL33_MOUSE
resolver
uniprot_sec
Q2YEJ4
resolver
uniprot_sec
Q3TQN0
resolver
uniprot_sec
Q99L46
resolver
amino_acid_sequence
MRPRMKYSNSKISPAKFSSTAGEALVPPCKIRRSQQKTKEFCHVYCMRLRSGLTIRKETSYFRKEPTKRYSLKSGTKHEENFSAYPRDSRKRSLLGSIQAFAASVDTLSIQGTSLLTQSPASLSTYNDQSVSFVLENGCYVINVDDSGKDQEQDQVLLRYYESPCPASQSGDGVDGKKLMVNMSPIKDTDIWLHANDKDYSVELQRGDVSPPEQAFFVLHKKSSDFVSFECKNLPGTYIGVKDNQLALVEEKDESCNNIMFKLSKI
uniprot
proteins
function
FUNCTION: Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:29045903). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines (By similarity). Also involved in activation of mast cells, basophils, eosinophils and natural killer cells (By similarity). Acts as an enhancer of polarization of alternatively activated macrophages (By similarity). Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (By similarity). Induces rapid UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (PubMed:34644537). {ECO:0000250|UniProtKB:O95760, ECO:0000269|PubMed:29045903, ECO:0000269|PubMed:34644537}.; FUNCTION: In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (By similarity). This form is rapidely lost upon angiogenic or pro-inflammatory activation (By similarity). {ECO:0000250|UniProtKB:O95760}.
uniprot
proteins
mass_dalton
29991
uniprot
proteins
post_translational_modification
PTM: The full-length protein can be released from cells and is able to signal via the IL1RL1/ST2 receptor (PubMed:16286016). However, proteolytic processing by CELA1, CSTG/cathepsin G and ELANE/neutrophil elastase produces C-terminal peptides that are more active than the unprocessed full-length protein (PubMed:22307629, PubMed:35749514). May also be proteolytically processed by calpains. Proteolytic cleavage mediated by apoptotic caspases including CASP3 and CASP7 results in IL33 inactivation (PubMed:16286016, PubMed:19465481). In vitro proteolytic cleavage by CASP1 was reported (PubMed:16286016) but could not be confirmed in vivo (PubMed:19465481) suggesting that IL33 is probably not a direct substrate for that caspase (PubMed:16286016, PubMed:19465481). {ECO:0000269|PubMed:16286016, ECO:0000269|PubMed:19465481, ECO:0000269|PubMed:22307629, ECO:0000269|PubMed:35749514}.
uniprot
proteins
protein_family
IL-1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16286016
uniprot
proteins
pubmed
19465481
uniprot
proteins
pubmed
21734074
uniprot
proteins
pubmed
22307629
uniprot
proteins
pubmed
29045903
uniprot
proteins
pubmed
34644537
uniprot
proteins
pubmed
35749514
uniprot
proteins
pubmed
35794369
uniprot
proteins
sequence_length
266
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:34644537}. Chromosome {ECO:0000250|UniProtKB:O95760}. Cytoplasm {ECO:0000250|UniProtKB:O95760}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:O95760}. Secreted {ECO:0000269|PubMed:35749514, ECO:0000269|PubMed:35794369}. Note=Secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore following cleavage by CELA1 (PubMed:35749514, PubMed:35794369). Associates with heterochromatin and mitotic chromosomes (By similarity). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (By similarity). {ECO:0000250|UniProtKB:O95760, ECO:0000269|PubMed:35749514, ECO:0000269|PubMed:35794369}.; SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29045903}. Note=(Microbial infection) Upon infection with H.polygyrus, tethered to the nucleus by the H.polygyrus parasitic protein ARI. {ECO:0000269|PubMed:29045903}.
uniprot
proteins