Hsd17b7
entrez
15490
canonical
uniprot
O88736
canonical
ensembl
ENSMUSG00000026675
resolver
ensp
ENSMUSP00000027989
resolver
ensp
ENSMUSP00000106985
resolver
ensp
ENSMUSP00000269199
resolver
ensp
ENSMUSP00000269201
resolver
enst
ENSMUST00000027989
resolver
enst
ENSMUST00000111353
resolver
genesymbol
Hsd17b7
resolver
genesymbol_syn
17hsd7
resolver
uniprot
F6W2I7
resolver
uniprot
Q8C5N9
resolver
uniprot
Q8K5C9
resolver
uniprot
Q921L1
resolver
uniprot_entry
DHB7_MOUSE
resolver
uniprot_entry
F6W2I7_MOUSE
resolver
uniprot_entry
Q8C5N9_MOUSE
resolver
uniprot_sec
Q8K5C9
resolver
uniprot_sec
Q921L1
resolver
amino_acid_sequence
MRKVVLITGASSGIGLALCGRLLAEDDDLHLCLACRNLSKARAVRDTLLASHPSAEVSIVQMDVSSLQSVVRGAEEVKQKFQRLDYLYLNAGILPNPQFNLKAFFCGIFSRNVIHMFTTAEGILTQNDSVTADGLQEVFETNLFGHFILIRELEPLLCHADNPSQLIWTSSRNAKKANFSLEDIQHSKGPEPYSSSKYATDLLNVALNRNFNQKGLYSSVMCPGVVMTNMTYGILPPFIWTLLLPIMWLLRFFVNALTVTPYNGAEALVWLFHQKPESLNPLTKYASATSGFGTNYVTGQKMDIDEDTAEKFYEVLLELEKRVRTTVQKSDHPS
uniprot
proteins
ec_number
1.1.1.210
uniprot
proteins
ec_number
1.1.1.270
uniprot
proteins
ec_number
1.1.1.62
uniprot
proteins
function
FUNCTION: Bifunctional enzyme involved in steroid-hormone metabolism and cholesterol biosynthesis (PubMed:12732193, PubMed:12829805, PubMed:20659585, PubMed:9658408). Catalyzes the NADP(H)-dependent reduction of estrogens and androgens and regulates the biological potency of these steroids. Converts estrone (E1)to a more potent estrogen, 17beta-estradiol (E2) (PubMed:12732193, PubMed:9658408). Converts moderately dihydrotestosterone (DHT) to their inactive forms 5a-androstane-3beta,17b-diol and 5alpha-androstane-3alpha,17beta-diol (PubMed:12732193). Does not metabolize progesterone (PubMed:12732193). Additionally, participates in the post-squalene cholesterol biosynthesis, as a 3-ketosteroid reductase (PubMed:12829805, PubMed:20659585). {ECO:0000269|PubMed:12732193, ECO:0000269|PubMed:12829805, ECO:0000269|PubMed:20659585, ECO:0000269|PubMed:9658408}.
uniprot
proteins
mass_dalton
37317
uniprot
proteins
pathway_participation
PATHWAY: Steroid biosynthesis; estrogen biosynthesis. {ECO:0000269|PubMed:12732193, ECO:0000269|PubMed:9658408}.; PATHWAY: Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6. {ECO:0000269|PubMed:12829805}.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000250|UniProtKB:Q62904}.
uniprot
proteins
protein_family
ERG27 subfamily
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
12732193
uniprot
proteins
pubmed
12829805
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18669642
uniprot
proteins
pubmed
20659585
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9658408
uniprot
proteins
sequence_length
334
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:12829805}; Single-pass membrane protein {ECO:0000255}. Note=Colocalizes with HMGCR in a wide range of tissues during embryonic development. {ECO:0000269|PubMed:12829805}.
uniprot
proteins
transmembrane_region
TRANSMEM 230..250; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins