Q9ES14
uniprot
Q9ES14
canonical
amino_acid_sequence
MLPKVLLMLLNMFLALQWRVGPHIKLENKPPAQDKVVFGPQPQPSGKKLPARETELTADHTTERPRGKLTRASQILNTILSNYDHKLRPSIGEKPTVVTVKVFVNSLGPISILDMEYSIDIIFYQTWYDERLRYNDTFETLILHGNVVSQLWIPDTFFRNSKRTQEYDITIPNQMALIHKDGKVLYTVRMTIDARCSLHMLNFPMDSHSCPLSFSSFSYDEHEMIYKWENFKLKIDAKNTWKLLEFDFTGVNNKTEIISTPVGDFMVMTFFFNVSRRFGFIVFQNYIPSSVTTMLSWVSFWIKIEAAAARASVGVSSVLTMATLGTFSRKNFPRVSYLTALDFYIAICFVLCFCTLLEFTVLNFLTYNNIERQASPKFYQFPTNSRANARTRARARTRARARARARQQQEVFVCEIVTYEENAEEGYQWSPRSRRPQCPWRRCGRSYVCFRVLRKYFCMVPGCEGNNWQRGRICIHVYRLDNYSRVLFPITFFFFNVVYWVICLNL
uniprot
proteins
function
FUNCTION: Epsilon subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (By similarity). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). GABARs containing epsilon subunit may also permit spontaneous chloride channel activity while preserving the structural information required for GABA-gated openings (By similarity). GABARs containing epsilon subunit may regulate cardiac function (By similarity). {ECO:0000250|UniProtKB:P08219, ECO:0000250|UniProtKB:P47870, ECO:0000250|UniProtKB:P78334}.
uniprot
proteins
mass_dalton
59219
uniprot
proteins
protein_family
GABRE sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
10804200
uniprot
proteins
pubmed
11122342
uniprot
proteins
sequence_length
506
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 278..298; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 309..328; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 345..365; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 486..506; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins