Smg6
entrez
103677
canonical
uniprot
P61406
canonical
ensembl
ENSMUSG00000038290
resolver
ensp
ENSMUSP00000043555
resolver
enst
ENSMUST00000045281
resolver
genesymbol
Smg6
resolver
genesymbol_syn
Est1a
resolver
genesymbol_syn
Kiaa0732
resolver
uniprot
Q5NC64
resolver
uniprot_entry
EST1A_MOUSE
resolver
uniprot_sec
Q5NC64
resolver
amino_acid_sequence
MAEGLERVRISASELRGILATLAPQAGSRENMKELKEPRQRKDNRRPDLEIYKPGLSRLRNRPKTKEASGNEEFKDEIVNDRDSSAVGNDTQLIQVCKELDSQQQNGPIDAENSQAQETFPKTVGLEDRSLKIIKRSKKPDLQIYQPGRRLQTITKESAGRADEEEILNQVEQLRIEEDECKGEAIKEEVNNKPDKTEIEKHQSNDRVRTAKGEKGKKIEKGEGSKKVADDSVPGKPGSVKRYSRSDKRRNRYRTCSTSSAGSNNSAEGAGLTDNGCRRRRQDRAKERPRLKKQVSLSSTDSLDEDRVDEPDVLGSRRSSERKKHLERNWSGCGEGEQKSNGKENRSALRVTFDAETMSKDSPVVRSVKDNVDRMKSDKGPSSGGKGSEKQELRHPRQELRDRGRGILILPAHTALSVSSSGSPESTPLGPRLLFGSGSKGSRSWGRGGTTRRLWDPNNPDQKPALKSQTPQLHFLDTDDEISPTSWGDSRQAQASYYKFQNSDNPYYYPRTPGPASQYPYAGYSPLQYPVGPTNGMYPGAYYPGYPAPSGQYVCSPLPASTMSPEEIEQHVRNMQQQELHRLLRVADNQELQLSNLLSRDRISTEGMEKMAQLRTELLQLYERCILLDIEFSDSQNVDQILWKNAFYQVIEKFRQLLKDPNSENPEQIRNRLLELLDEGSDFFDSLLQKLQVTYKFKLEDYMDGLAIRSKPLRKTVKYALISAQRSMICQGDISRYREQANDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAASNPILTAKESLMSLFEETKRKAEQMEKKQHEEFDMSPDKWRKGKKSTFRHVGDDTTRLEIWIHPSHSRSAQGTESGKDSEQENGLGSLSPSDLNKRFILSFLHAHGKLFTRIGMETFPAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKDCFSEECRSVIQEQAASLGLAMFSLLVQRCTCLLKDSAKAQLSSPEDQEDQDDIKVSSFVPDLKELLPSVKVWSDWMLGYPDTWNPPPTSLDLPLQVAVDVWSTLADFCNILTAVNQSEVPLYKDPDDDLTLLILEEDRLLSGFVPLLAAPQDPCYVEKTSDKVIAADCKRVTVLKYFLEALCGQEEPLLAFKGGKYVSVAPVPDTMGKEMGSQEGKQLEDEEEDVVIEDFEEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDQSQMRQMELEIRPLFLVPDTNGFIDHLASLARLLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKARKSIEFLERRFESRDSCLRALTSRGNELESIAFRSEDITGQLGNNDDLILSCCLHYCKDKAKDYMPTSKEEPIRLLREVVLLTDDRNLRVKALTRNVPVRDIPAFLTWAQVG
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
function
FUNCTION: Component of the telomerase ribonucleoprotein (RNP) complex that is essential for the replication of chromosome termini. May have a general role in telomere regulation. Promotes in vitro the ability of TERT to elongate telomeres. Overexpression induces telomere uncapping, chromosomal end-to-end fusions (telomeric DNA persists at the fusion points) and did not perturb TRF2 telomeric localization. Binds to the single-stranded 5'-(GTGTGG)(4)GTGT-3' telomeric DNA, but not to a telomerase RNA template component (TER). {ECO:0000250|UniProtKB:Q86US8}.; FUNCTION: Plays a role in nonsense-mediated mRNA decay. Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA. {ECO:0000250|UniProtKB:Q86US8}.
uniprot
proteins
mass_dalton
160496
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
1418
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250|UniProtKB:Q86US8}. Chromosome, telomere {ECO:0000250|UniProtKB:Q86US8}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q86US8}. Note=Particularly enriched in the nucleolus. {ECO:0000250|UniProtKB:Q86US8}.
uniprot
proteins