AK7
entrez
122481
canonical
uniprot
Q96M32
canonical
ensembl
ENSG00000140057
resolver
ensp
ENSP00000267584
resolver
ensp
ENSP00000526762
resolver
ensp
ENSP00000526763
resolver
ensp
ENSP00000526764
resolver
ensp
ENSP00000694922
resolver
enst
ENST00000267584
resolver
genesymbol
AK7
resolver
hgnc
HGNC:20091
resolver
uniprot
Q8IYP6
resolver
uniprot_entry
KAD7_HUMAN
resolver
uniprot_sec
Q8IYP6
resolver
amino_acid_sequence
MAEEEETAALTEKVIRTQRVFINLLDSYSSGNIGKFLSNCVVGASLEEITEEEEEEDENKSAMLEASSTKVKEGTFQIVGTLSKPDSPRPDFAVETYSAISREDLLMRLLECDVIIYNITESSQQMEEAIWAVSALSEEVSHFEKRKLFILLSTVMTWARSKALDPEDSEVPFTEEDYRRRKSHPNFLDHINAEKMVLKFGKKARKFAAYVVAAGLQYGAEGGMLHTFFKMAWLGEIPALPVFGDGTNVIPTIHVLDLAGVIQNVIDHVPKPHYLVAVDESVHTLEDIVKCISKNTGPGKIQKIPRENAYLTKDLTQDCLDHLLVNLRMEALFVKENFNIRWAAQTGFVENINTILKEYKQSRGLMPIKICILGPPAVGKSSIAKELANYYKLHHIQLKDVISEAIAKLEAIVAPNDVGEGEEEVEEEEEEENVEDAQELLDGIKESMEQNAGQLDDQYIIRFMKEKLKSMPCRNQGYILDGFPKTYDQAKDLFNQEDEEEEDDVRGRMFPFDKLIIPEFVCALDASDEFLKERVINLPESIVAGTHYSQDRFLRALSNYRDINIDDETVFNYFDELEIHPIHIDVGKLEDAQNRLAIKQLIKEIGEPRNYGLTDEEKAEEERKAAEERLAREAAEEAEREHQEAVEMAEKIARWEEWNKRLEEVKREERELLEAQSIPLRNYLMTYVMPTLIQGLNECCNVRPEDPVDFLAEYLFKNNPEAQ
uniprot
proteins
disease_involvement
DISEASE: Spermatogenic failure 27 (SPGF27) [MIM:617965]: An autosomal recessive infertility disorder caused by spermatogenesis defects that result in multiple morphologic abnormalities of the sperm flagella, including short, irregular, coiled, or absent flagella. {ECO:0000269|PubMed:29365104}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.4.3
uniprot
proteins
ec_number
2.7.4.6
uniprot
proteins
function
FUNCTION: Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has highest activity toward AMP, and weaker activity toward dAMP, CMP and dCMP. Also displays broad nucleoside diphosphate kinase activity. Involved in maintaining ciliary structure and function. {ECO:0000269|PubMed:21080915, ECO:0000269|PubMed:23416111}.
uniprot
proteins
mass_dalton
82658
uniprot
proteins
protein_family
Adenylate kinase family; Dpy-30 family
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
21080915
uniprot
proteins
pubmed
23416111
uniprot
proteins
pubmed
29365104
uniprot
proteins
sequence_length
723
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:21080915}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:29365104}. Note=Detected along the full length of sperm flagellum, where it colocalizes with alpha-tubulin. {ECO:0000269|PubMed:29365104}.
uniprot
proteins