Exosc9
entrez
50911
canonical
uniprot
Q9JHI7
canonical
ensembl
ENSMUSG00000027714
resolver
ensp
ENSMUSP00000029269
resolver
enst
ENSMUST00000029269
resolver
genesymbol
Exosc9
resolver
genesymbol_syn
Pmscl1
resolver
uniprot
Q9CSZ2
resolver
uniprot_entry
EXOS9_MOUSE
resolver
uniprot_sec
Q9CSZ2
resolver
amino_acid_sequence
MKETPLSNCERRFLLRAIEEKKRLDGRQTYDYRNIRISFGTDYGCCIVELGKTRVLGQVSCELVSPKLNRATEGILFFNLELSQMAAPAFEPGRQSDLLVKLNRLLERCLRNSKCIDTESLCVVAGEKVWQIRVDLHLLNHDGNIIDAASIAAIVALCHFRRPDVSVQGEEVTLYTPEERDPVPLSIHHMPICVSFAFFQQGTYLLVDPNEREERVMDGLLVIAMNKHREICTIQSSGGIMLLKDQVFRCSKIAGVKVAEITELIQKALENDQRVRKEGGKFGFAESIANQRITAFKMETAPIDTSNIEERAEEIIAEAEPPPEVVSQPVLWTPGTAQIGDGIENSWGDLEDSEKEEEEEEGGIDEAVILDDTKMDTGEVSDIGSQGAPIVLSDSEEEEMIILEPEKNPKKIRAQTSANQKAPSKGQGKRKKKKRTAN
uniprot
proteins
function
FUNCTION: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC9 binds to ARE-containing RNAs (By similarity). {ECO:0000250|UniProtKB:Q06265}.
uniprot
proteins
mass_dalton
48937
uniprot
proteins
protein_family
RNase PH family
uniprot
proteins
pubmed
10708524
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
438
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q06265}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q06265}. Nucleus {ECO:0000250|UniProtKB:Q06265}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q06265}. Note=Colocalizes with SETX in nuclear foci upon induction of transcription-related DNA damage at the S phase (By similarity). {ECO:0000250|UniProtKB:Q06265}.
uniprot
proteins