P3h3
entrez
14789
canonical
uniprot
Q8CG70
canonical
ensembl
ENSMUSG00000023191
resolver
ensp
ENSMUSP00000023958
resolver
enst
ENSMUST00000023958
resolver
genesymbol
P3h3
resolver
genesymbol_syn
Leprel2
resolver
uniprot
O88836
resolver
uniprot_entry
P3H3_MOUSE
resolver
uniprot_sec
O88836
resolver
amino_acid_sequence
MLRLLRLLLLLLLPPPGSPEPPEPPGLAQLSPGSPPQAPDLLYADGLRAYSAGAWAPAVALLREALRSRAALGRARQECGASCAAEPGAALPSQLLGAPHPVSGPGVWEPLLLRATLRRAECLTQCAVRRLGPGGAARLRVGSALRDAFRRREPYNYLQRAYYQLKKLDLAASAAHTFFVANPTHLQMREDMAKYRRMSAIRPQSFRDLVTPLYWAAYDTGLELLEQREAALALPQLEEALQGSLAHMESCRAACEGPEEHQGAEEEGEGSQGGLYEAIAGHWIRVLQCRQHCVADTATRPGRSFPVQDFLLSQLRRLHEAYAQVGNMSQAMENVLSVLLFYPEDEAAKKALNQYQTQLGEPRPDLGPREDIQRFILRSLGEKRQLYYAMEHLGTSFKDPDSWTPEALIPKALRERLREDQEKKPWDHQPPQQKPLAHWKDALLMEGVTLTQDAQQLNGSERAVLDGLLTSAECGVLLQLAKDAAQAGARSGYRGRRSPHSPHERFEGLTVLKAAQLARAGTVGRPGAKLLLEVSERVRTLTQAYFSPERPLHLSFTHLVCRSAIEGEQEQRMDLSHPVHADNCVLDPDTGECWREPPAYTYRDYSGLLYLNDDFKGGDLFFTQPNALTVTAQVRPRCGRLVAFSSGGENPHGVWAVTRGRRCALALWHTWAPEHSEQEWTEAKELLQEEEEEEEEEDILSRDPSPEPPSHKLQRVQEKAGKPRRVRVREEL
uniprot
proteins
ec_number
1.14.11.7
uniprot
proteins
function
FUNCTION: Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linkling of collagen fibrils (PubMed:27119146). Required for normal hydroxylation of lysine residues in type I collagen chains in skin, bone, tendon, aorta and cornea (PubMed:28115524, PubMed:33631195). Required for normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly (PubMed:27119146, PubMed:28115524, PubMed:33631195). Apparently not required for normal prolyl 3-hydroxylation on collagen chains, either because a proline substrate for P3H3 remains to be identified or because the enzyme has lost its enzymatic activity (PubMed:28115524). Also requires for lysyl hydroxylation of type V collagen in the skin, either by supporting hydroxylation of type V collagen by PLOD2/LH2 or by having itself a lysyl hydroxylase activity (PubMed:33631195). {ECO:0000269|PubMed:27119146, ECO:0000269|PubMed:28115524, ECO:0000269|PubMed:33631195}.
uniprot
proteins
mass_dalton
81701
uniprot
proteins
protein_family
Leprecan family
uniprot
proteins
pubmed
15044469
uniprot
proteins
pubmed
15063763
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27119146
uniprot
proteins
pubmed
28115524
uniprot
proteins
pubmed
33631195
uniprot
proteins
pubmed
9445485
uniprot
proteins
sequence_length
732
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000255|PROSITE-ProRule:PRU10138}.
uniprot
proteins