Taar1
entrez
113914
canonical
uniprot
Q923Y9
canonical
ensembl
ENSRNOG00000016073
resolver
ensp
ENSRNOP00000021510
resolver
ensp
ENSRNOP00000076392
resolver
enst
ENSRNOT00000021510
resolver
enst
ENSRNOT00000097590
resolver
genesymbol
Taar1
resolver
genesymbol_syn
Ta1
resolver
genesymbol_syn
Tar1
resolver
genesymbol_syn
Trar1
resolver
uniprot
A0A0G2JSP2
resolver
uniprot
Q5QD26
resolver
uniprot
Q8VHQ5
resolver
uniprot_entry
A0A0G2JSP2_RAT
resolver
uniprot_entry
TAAR1_RAT
resolver
uniprot_sec
Q5QD26
resolver
uniprot_sec
Q8VHQ5
resolver
amino_acid_sequence
MHLCHNSANISHTNSNWSRDVRASLYSLISLIILTTLVGNLIVIISISHFKQLHTPTNWLLHSMAVVDFLLGCLVMPYSMVRTVEHCWYFGELFCKLHTSTDIMLSSASILHLAFISIDRYYAVCDPLRYKAKINLAAIFVMILISWSLPAVFAFGMIFLELNLEGVEELYHNQVFCLRGCFPFFSKVSGVLAFMTSFYIPGSVMLFVYYRIYFIAKGQARSINRANLQVGLEGESRAPQSKETKAAKTLGIMVGVFLLCWCPFFFCMVLDPFLGYVIPPTLNDTLNWFGYLNSAFNPMVYAFFYPWFRRALKMVLFGKIFQKDSSRSKLFL
uniprot
proteins
function
FUNCTION: Intracellular G protein-coupled receptor for trace amines, which recognizes endogenous amine-containing metabolites such as beta-phenylethylamine (beta-PEA), 3-iodothyronamine (T1AM), isoamylamine (IAA), cadaverine (CAD), cyclohexylamine (CHA), p-tyramine (p-TYR), trimethylamine (TMA), octopamine and tryptamine (PubMed:15718104). Also functions as a receptor for various drugs and psychoactive substances, such as amphetamine and methamphetamine (By similarity). Unresponsive to classical biogenic amines, such as epinephrine and histamine and only partially activated by dopamine and serotonin (By similarity). Expressed in both the central and peripheral nervous system: TAAR1 activation regulates the activity of several neurotransmitter signaling pathways by (1) decreasing the basal firing rates of the neurons involved and by (2) lowering the sensitivity of receptors to neurotransmitters (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (By similarity). TAAR1 is coupled with different G(i)/G(o)-, G(s)- or G(q)/G(11) classes of G alpha proteins depending on the ligand (By similarity). CAD-binding is coupled to G(i)/G(o) G alpha proteins and mediates inhibition of adenylate cyclase activity (By similarity). T1AM- or beta-PEA-binding is coupled to G(s) G alpha proteins and mediates activation of adenylate cyclase activity (By similarity). CHA- or IAA-binding is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers (By similarity). TMA-binding is coupled with all three G(i)/G(o)-, G(s)- or G(q)/G(11) G alpha protein subtypes (By similarity). {ECO:0000250|UniProtKB:Q96RJ0, ECO:0000269|PubMed:15718104}.
uniprot
proteins
mass_dalton
38021
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11459929
uniprot
proteins
pubmed
11723224
uniprot
proteins
pubmed
15718104
uniprot
proteins
sequence_length
332
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endomembrane system {ECO:0000250|UniProtKB:Q96RJ0}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q96RJ0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96RJ0}. Cell membrane {ECO:0000250|UniProtKB:Q96RJ0}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q96RJ0}. Note=Localizes mainly intracellularly. Partially colocalizes with the endoplasmic reticulum; also found at lower lever at the plasma membrane. {ECO:0000250|UniProtKB:Q96RJ0}.
uniprot
proteins
transmembrane_region
TRANSMEM 25..45; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 59..79; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 98..118; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 139..159; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 188..208; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 250..270; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 288..308; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins