Pcgf6
entrez
71041
canonical
uniprot
Q99NA9
canonical
ensembl
ENSMUSG00000025050
resolver
ensp
ENSMUSP00000026032
resolver
ensp
ENSMUSP00000165231
resolver
ensp
ENSMUSP00000165232
resolver
ensp
ENSMUSP00000165234
resolver
ensp
ENSMUSP00000165243
resolver
enst
ENSMUST00000026032
resolver
genesymbol
Pcgf6
resolver
genesymbol_syn
Mblr
resolver
genesymbol_syn
Rnf134
resolver
uniprot_entry
PCGF6_MOUSE
resolver
amino_acid_sequence
MDEAETDATENKRASEAKRASAMPPPPPPPPPISPPALIPAPAAGEEGPASLGQAGAAGCSRSRPPALEPERSLGRLRGRFEDYDEELEEEEEMEEEEEEEEEMSHFSLRLESGRADSEDEEERLINLVELTPYILCSICKGYLIDATTITECLHTFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVINLEEREKKQMHDFYKERGLEVPKPAAPQPVPSSKGKTKKVLESVFRIPPELDMSLLLEFIGANEDTGHFKPLEKKFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLERYQTLREIRRAIGDTAMQDGLLVLHYGLVVSPLKIT
uniprot
proteins
function
FUNCTION: Transcriptional repressor. May modulate the levels of histone H3K4Me3 by activating KDM5D histone demethylase. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity. {ECO:0000250|UniProtKB:Q9BYE7}.
uniprot
proteins
mass_dalton
39820
uniprot
proteins
post_translational_modification
PTM: Phosphorylated during mitosis. {ECO:0000250|UniProtKB:Q9BYE7}.
uniprot
proteins
pubmed
12167161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
353
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BYE7}.
uniprot
proteins