TGIF1
entrez
7050
canonical
uniprot
Q15583
canonical
ensembl
ENSG00000177426
resolver
ensp
ENSP00000327959
resolver
ensp
ENSP00000339631
resolver
ensp
ENSP00000343969
resolver
ensp
ENSP00000383031
resolver
ensp
ENSP00000384133
resolver
ensp
ENSP00000384970
resolver
ensp
ENSP00000385206
resolver
ensp
ENSP00000447747
resolver
ensp
ENSP00000448121
resolver
ensp
ENSP00000450025
resolver
ensp
ENSP00000483499
resolver
genesymbol
TGIF1
resolver
genesymbol_syn
TGIF
resolver
hgnc
HGNC:11776
resolver
uniprot
A6NE42
resolver
uniprot
A6NLU7
resolver
uniprot
F8VZB6
resolver
uniprot
Q6ICR0
resolver
uniprot
Q8N5X9
resolver
uniprot
Q9NRS0
resolver
uniprot_entry
TGIF1_HUMAN
resolver
uniprot_sec
A6NE42
resolver
uniprot_sec
A6NLU7
resolver
uniprot_sec
F8VZB6
resolver
uniprot_sec
Q6ICR0
resolver
uniprot_sec
Q8N5X9
resolver
uniprot_sec
Q9NRS0
resolver
amino_acid_sequence
MVLAQSRVSAGVGSPHCSGSGGGGSDSFPWPASHPGNPQCSFSTAFLASPRLSRGTLAYLPPAPWSSLATPSALLGSSCAPPPPPARCPQPRALSPELGTKAGPRRPHRWELPRSPSQGAQGPAPRRRLLETMKGIVAASGSETEDEDSMDIPLDLSSSAGSGKRRRRGNLPKESVQILRDWLYEHRYNAYPSEQEKALLSQQTHLSTLQVCNWFINARRRLLPDMLRKDGKDPNQFTISRRGAKISETSSVESVMGIKNFMPALEETPFHSCTAGPNPTLGRPLSPKPSSPGSVLARPSVICHTTVTALKDVPFSLCQSVGVGQNTDIQQIAAKNFTDTSLMYPEDTCKSGPSTNTQSGLFNTPPPTPPDLNQDFSGFQLLVDVALKRAAEMELQAKLTA
uniprot
proteins
disease_involvement
DISEASE: Holoprosencephaly 4 (HPE4) [MIM:142946]: A form of holoprosencephaly, a structural anomaly of the brain in which the developing forebrain fails to correctly separate into right and left hemispheres. It is a genetically and clinically heterogeneous disorder with a wide spectrum of severity, ranging from alobar holoprosencephaly with severe facial abnormalities, such as cyclopia and proboscis, to mild forms that include lobar or microform holoprosencephaly, without cerebral malformations and with mild craniofacial defects. HPE4 inheritance is autosomal dominant. {ECO:0000269|PubMed:10835638, ECO:0000269|PubMed:15221788}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.
uniprot
proteins
mass_dalton
43013
uniprot
proteins
protein_family
TALE/TGIF homeobox family
uniprot
proteins
pubmed
10764806
uniprot
proteins
pubmed
10835638
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15221788
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16177791
uniprot
proteins
pubmed
8537382
uniprot
proteins
sequence_length
401
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins