IL21R
entrez
50615
canonical
uniprot
Q9HBE5
canonical
ensembl
ENSG00000103522
resolver
ensp
ENSP00000338010
resolver
ensp
ENSP00000379103
resolver
ensp
ENSP00000456707
resolver
ensp
ENSP00000541405
resolver
ensp
ENSP00000541406
resolver
ensp
ENSP00000614603
resolver
ensp
ENSP00000614604
resolver
enst
ENST00000337929
resolver
enst
ENST00000395754
resolver
enst
ENST00000564089
resolver
enst
ENST00000871346
resolver
enst
ENST00000871347
resolver
enst
ENST00000944544
resolver
enst
ENST00000944545
resolver
genesymbol
IL21R
resolver
genesymbol_syn
NILR
resolver
hgnc
HGNC:6006
resolver
uniprot
A8K9E8
resolver
uniprot
D3DWF7
resolver
uniprot
Q96HZ1
resolver
uniprot
Q9HB91
resolver
uniprot_entry
IL21R_HUMAN
resolver
uniprot_sec
A8K9E8
resolver
uniprot_sec
D3DWF7
resolver
uniprot_sec
Q96HZ1
resolver
uniprot_sec
Q9HB91
resolver
amino_acid_sequence
MPRGWAAPLLLLLLQGGWGCPDLVCYTDYLQTVICILEMWNLHPSTLTLTWQDQYEELKDEATSCSLHRSAHNATHATYTCHMDVFHFMADDIFSVNITDQSGNYSQECGSFLLAESIKPAPPFNVTVTFSGQYNISWRSDYEDPAFYMLKGKLQYELQYRNRGDPWAVSPRRKLISVDSRSVSLLPLEFRKDSSYELQVRAGPMPGSSYQGTWSEWSDPVIFQTQSEELKEGWNPHLLLLLLLVIVFIPAFWSLKTHPLWRLWKKIWAVPSPERFFMPLYKGCSGDFKKWVGAPFTGSSLELGPWSPEVPSTLEVYSCHPPRSPAKRLQLTELQEPAELVESDGVPKPSFWPTAQNSGGSAYSEERDRPYGLVSIDTVTVLDAEGPCTWPCSCEDDGYPALDLDAGLEPSPGLEDPLLDAGTTVLSCGCVSAGSPGLGGPLGSLLDRLKPPLADGEDWAGGLPWGGRSPGGVSESEAGSPLAGLDMDTFDSGFVGSDCSSPVECDFTSPGDEGPPRSYLRQWVVIPPPLSSPGPQAS
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency 56 (IMD56) [MIM:615207]: An autosomal recessive primary immunodeficiency characterized by B- and T-cell defects and variable dysfunction of NK cells. Patients tend to have normal numbers of lymphocytes, but show defective class-switched B-cells, low IgG, defective antibody response, and defective T-cell responses to certain antigens. {ECO:0000269|PubMed:23440042}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Note=Chromosomal aberrations involving IL21R is a cause of B-cell non-Hodgkin lymphomas (B-cell NHL). Translocation t(3;16)(q27;p11), with BCL6.
uniprot
proteins
function
FUNCTION: This is a receptor for interleukin-21.
uniprot
proteins
mass_dalton
59130
uniprot
proteins
post_translational_modification
PTM: C-mannosylated at Trp-214 in the WSXWS motif, the sugar chain makes extensive hydrogen bonds with Asn-73 sugar, and bridges the two fibronectin domains transforming the V-shaped receptor into an A-frame.
uniprot
proteins
protein_family
Type 4 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
11016959
uniprot
proteins
pubmed
11081504
uniprot
proteins
pubmed
11821949
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22235133
uniprot
proteins
pubmed
23440042
uniprot
proteins
sequence_length
538
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 233..253; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins