Rnf217
entrez
268291
canonical
uniprot
D3YYI7
canonical
ensembl
ENSMUSG00000063760
resolver
ensp
ENSMUSP00000080650
resolver
enst
ENSMUST00000081989
resolver
genesymbol
Rnf217
resolver
genesymbol_syn
Ibrdc1
resolver
uniprot_entry
RN217_MOUSE
resolver
amino_acid_sequence
MGEEQSTVSGSGGARASGGGSAGQPESPRPRGDRVRTAGPRAAASSSRPNGGGGGRDPGCVDASVQEPASNRAPAGQPARLPLSGPLDPQSLELQLEREAEGAGPREAPPGQQPPDGLLLDVLAQRHPPPAKPQVLCSVYCVESDLPEAPSAESPSPSESPPQAPLGPIPASPPPSFPSSPLSLPADPLSPDGGSIELEFYLAPEPFSVPGLLGAPPYSGLGGVGDPYAPLMVLMCRVCLEDKPIKPLPCCKKAVCEECLKIYLSSQVQLGQVEIKCPVTECFEFLEETTVVYNLTHEDSIKYKYFLELGRIDSSTKPCPQCKHFTTFKKKGHIPTPSRSESRYKIQCPTCQLIWCFKCHSPWHEGVNCKEYKKGDKLLRHWASEIEHGQRNAQKCPKCKIHIQRTEGCDHMTCSQCNTNFCYRCGERYRQLRFFGDHTSNLSIFGCKYRYLPERPHLRRLVRGSVCAGKLFIAPLILVLGLALGAIAVVIGLFVFPIYCLCKKQRKRSRTGMHW
uniprot
proteins
ec_number
2.3.2.31
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the degradation of the iron exporter ferroportin/SLC40A1 and thus regulates iron homeostasis. {ECO:0000269|PubMed:33895792}.
uniprot
proteins
mass_dalton
56036
uniprot
proteins
mutagenesis
MUTAGEN 236; /note="C->A: Loss of SLC40A1 degradation; when associated with A-239."; /evidence="ECO:0000269|PubMed:33895792"; MUTAGEN 239; /note="C->A: Loss of SLC40A1 degradation; when associated with A-236."; /evidence="ECO:0000269|PubMed:33895792"; MUTAGEN 409; /note="C->A: Loss of SLC40A1 degradation."; /evidence="ECO:0000269|PubMed:33895792
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
RBR family
uniprot
proteins
protein_family
RNF217 subfamily
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
33895792
uniprot
proteins
sequence_length
515
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cytoplasm {ECO:0000250|UniProtKB:Q8TC41}.
uniprot
proteins
transmembrane_region
TRANSMEM 476..496; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins