Tubal3
entrez
238463
canonical
uniprot
Q3UX10
canonical
ensembl
ENSMUSG00000021216
resolver
ensp
ENSMUSP00000021639
resolver
enst
ENSMUST00000021639
resolver
genesymbol
Tubal3
resolver
uniprot
B9EJS3
resolver
uniprot_entry
TBAL3_MOUSE
resolver
uniprot_sec
B9EJS3
resolver
amino_acid_sequence
MRECLSIHIGQAGVQIGDACWELYCLEHGIQPDGFILDHQHDNLENPKVEHMNASLDTFFHETRAGKHVPRTLFMDLEPTVIDGIRVGRYHSLFHPEQLVNGKEDAANTYARGRYSVGSEVIELVLERIRKLAEQCSGLQGFLIYRSFGGGTGSGFTSLLMERLSVEYCKKIKLEFSVYPSPRISTAVVEPYNAILTTHSTIEYSDCAFMVDNEALYDICQHKLGIERPSYASINRLIAQVSSSITASLRFEGPLNVDLIEFQTNLVPYPRIHFPITALAPIISAEKAYQEQLSVSDVTASCFEVSNQLVKCDPRLGKYMACCLLYRGDVVPKDVNEAIAAMKSRTSVQFVDWCPTGFKVGINYQPPAVVPGGDLARVQRAVCMLSNTTAIVEAWARLDHKFDLMYAKKAFLHWYITEGMELGEFVEAREDLAALEKDYEEVGLSF
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.
uniprot
proteins
mass_dalton
49988
uniprot
proteins
post_translational_modification
PTM: Some glutamate residues at the C-terminus are polyglycylated, resulting in polyglycine chains on the gamma-carboxyl group. Glycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering polyglycylation levels increases polyglutamylation, and reciprocally. Cilia and flagella glycylation is required for their stability and maintenance. Flagella glycylation controls sperm motility. {ECO:0000250|UniProtKB:P68369}.; PTM: Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group (By similarity). Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold (By similarity). Glutamylation is also involved in cilia motility (By similarity). {ECO:0000250|UniProtKB:P68369, ECO:0000250|UniProtKB:Q71U36}.
uniprot
proteins
protein_family
Tubulin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
446
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
uniprot
proteins