Syt11
entrez
60568
canonical
uniprot
O08835
canonical
ensembl
ENSRNOG00000020279
resolver
ensp
ENSRNOP00000027474
resolver
ensp
ENSRNOP00000091028
resolver
enst
ENSRNOT00000027474
resolver
genesymbol
Syt11
resolver
uniprot
A0A8L2QEY8
resolver
uniprot
Q505J5
resolver
uniprot
Q925B6
resolver
uniprot_entry
A0A8L2QEY8_RAT
resolver
uniprot_entry
Q505J5_RAT
resolver
uniprot_entry
SYT11_RAT
resolver
uniprot_sec
Q925B6
resolver
amino_acid_sequence
MAEITNIRPSFDVSPVAAGLIGASVLVVCVSVTVFVWTCCHQQAEKKHKTPPYKFIHMLKGISIYPETLSNKKKIIKVRRDKDGSHRESGRGNLLVNAESGLLSHDRDPRGPSPASCIDQLPIKRDYGEELRSPMTSLTPGESKPTSPSSPEEDVMLGSLTFSVDYNFPKKALVVTIQEAHGLPVMDGQTQGSDPYIKMTILPDKRHRVKTRVLRKTLDPVFDETFTFYGIPYSQLQDLVLHFLVLSFDRFSRDDVIGEVMVPLAGVDPSTGKVQLTRDIIKRNIQKCISRGELQVSLSYQPVAQRMTVVVLKARHLPKMDITGLSGNPYVKVNVYYGRKRIAKKKTHVKKCTLNPIFNESFIYDIPTDLLPDISIEFLVIDFDRTTKNEVVGRLILGAHSVTTSGAEHWREVCESPRKPVAKWHSLSEY
uniprot
proteins
function
FUNCTION: Synaptotagmin family member involved in vesicular and membrane trafficking which does not bind Ca(2+) (PubMed:9162066). Inhibits clathrin-mediated and bulk endocytosis in neurons, functions to ensure precision in vesicle retrieval (PubMed:26589353, PubMed:29311685). Plays an important role in dopamine transmission by regulating endocytosis and the vesicle-recycling process (PubMed:29311685). Essential component of a neuronal vesicular trafficking pathway that differs from the synaptic vesicle trafficking pathway but is crucial for development and synaptic plasticity. In macrophages and microglia, inhibits the conventional cytokine secretion, of at least IL6 and TNF, and phagocytosis. In astrocytes, regulates lysosome exocytosis, mechanism required for the repair of injured astrocyte cell membrane (By similarity). Required for the ATP13A2-mediated regulation of the autophagy-lysosome pathway (By similarity). {ECO:0000250|UniProtKB:Q9BT88, ECO:0000250|UniProtKB:Q9R0N3, ECO:0000269|PubMed:26589353, ECO:0000269|PubMed:29311685, ECO:0000269|PubMed:9162066}.
uniprot
proteins
mass_dalton
48268
uniprot
proteins
mutagenesis
MUTAGEN 247; /note="S->D: Restores Ca(2+)-binding and Ca(2+)-dependent phospholipid binding."; /evidence="ECO:0000269|PubMed:9162066"; MUTAGEN 345..346; /note="KK->AA: Loss of inhibition of clathrin-mediated and bulk endocytosis."; /evidence="ECO:0000269|PubMed:26589353
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, at least by PRKN, and targeted to the proteasome complex for degradation (PubMed:29311685). Ubiquitination is inhibited by ATP13A2 (By similarity). {ECO:0000250|UniProtKB:Q9BT88, ECO:0000269|PubMed:29311685}.
uniprot
proteins
protein_family
Synaptotagmin family
uniprot
proteins
pubmed
24882364
uniprot
proteins
pubmed
26589353
uniprot
proteins
pubmed
29311685
uniprot
proteins
pubmed
30021165
uniprot
proteins
pubmed
9162066
uniprot
proteins
sequence_length
430
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9R0N3}; Single-pass membrane protein {ECO:0000305}. Perikaryon {ECO:0000250|UniProtKB:Q9R0N3}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q9R0N3}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9R0N3}. Recycling endosome membrane {ECO:0000269|PubMed:26589353}; Single-pass membrane protein {ECO:0000305}. Lysosome membrane {ECO:0000250|UniProtKB:Q9R0N3}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9R0N3}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q9R0N3}. Cell projection, axon {ECO:0000269|PubMed:26589353}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9R0N3}. Postsynaptic density {ECO:0000250|UniProtKB:Q9R0N3}. Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269|PubMed:26589353}; Single-pass membrane protein {ECO:0000305}. Perikaryon {ECO:0000269|PubMed:26589353}. Note=Localized in vesicles that travels in axonal and dendritic shafts in both anterograde and retrograde directions. In macrophages and microglia, recruited in phagosomes at early stages of phagocytosis. {ECO:0000250|UniProtKB:Q9R0N3}.
uniprot
proteins
transmembrane_region
TRANSMEM 16..36; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins