Kcng4
entrez
66733
canonical
uniprot
Q80XM3
canonical
ensembl
ENSMUSG00000045246
resolver
ensp
ENSMUSP00000056552
resolver
ensp
ENSMUSP00000213230
resolver
ensp
ENSMUSP00000213231
resolver
ensp
ENSMUSP00000213236
resolver
enst
ENSMUST00000061828
resolver
genesymbol
Kcng4
resolver
uniprot_entry
KCNG4_MOUSE
resolver
amino_acid_sequence
MPMSSRDRDLHPGHHHFGSCSPLSQLWPGPEPKSVKGLYYSRARKVGNQDASPEANLKEILVNVGGQRYLLPWSTLDAFPLSRLSRLRLCRSHEEITQLCDDYDEDSQEFFFDRNPSAFGVIVSFLAAGKLVLLREMCALSFREELSYWGIEETNLERCCLRKLLKKLEEAAELRREEAAQRQQQRQACHSEVQASRWARSMNQLREMVEDPQSGLPGKVFACLSVLFVATTAVSLCVSTMPDFRAEEGKGECTRKCYYIFVVESICVAWFSLEFCLRFVQAPNKCQFFRGPLNVIDILAISPYYVSLAVSDESPEAGERPSSSSYLEKVGLVLRVLRALRILYVMRLARHSLGLQTLGLTVRRCAREFGLLMLFLAVAVTLFSPLVYVAENESGRVLEFTSIPASYWWAIISMTTVGYGDMVPRSVPGQMVALSSILSGILIMAFPATSIFHTFSHSYLELKREQEQVQARLRRLQNTNSASERELLSDVDDLVPEGLTSPGRYM
uniprot
proteins
function
FUNCTION: Regulatory subunit of the voltage-gated potassium (Kv) channel which, when coassembled with KCNB1, modulates the kinetics parameters of the heterotetrameric channel namely the time course of activation, deactivation and inactivation and on the voltage-dependence of activation. Potassium channel subunit that does not form functional channels by itself. Reduces the deactivation rate. Modulates the threshold for activation by shifting by approximately 20 mV in hyperpolarizing direction. Markedly changes the inactivation by shifting the voltage dependence of inactivation by approximately 40 mV in hyperpolarizing direction. Acceleratee activation and enhances the time course of activation. {ECO:0000250|UniProtKB:Q8TDN1}.
uniprot
proteins
mass_dalton
57177
uniprot
proteins
protein_family
G (TC 1.A.1.2) subfamily
uniprot
proteins
protein_family
Kv6.4/KCNG4 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
506
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8TDN1}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TDN1}. Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Colocalizes with KCNB1 at the plasma membrane. Remains intracellular in the absence of KCNB1. {ECO:0000250|UniProtKB:Q8TDN1}.
uniprot
proteins
transmembrane_region
TRANSMEM 217..238; /note="Helical; Name=Segment S1"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 260..281; /note="Helical; Name=Segment S2"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 293..312; /note="Helical; Name=Segment S3"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 327..351; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 367..388; /note="Helical; Name=Segment S5"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 431..459; /note="Helical; Name=Segment S6"; /evidence="ECO:0000250|UniProtKB:P63142
uniprot
proteins