Mug2
entrez
17837
canonical
uniprot
P28666
canonical
ensembl
ENSMUSG00000030131
resolver
ensp
ENSMUSP00000080469
resolver
enst
ENSMUST00000081777
resolver
genesymbol
Mug2
resolver
genesymbol_syn
Mug-2
resolver
uniprot_entry
MUG2_MOUSE
resolver
amino_acid_sequence
MWKSRRAQLCLFSVLLAFLPSASSLNGDSKYMVLVPSQLYTETPEKICLHLYHLNETVTVTASLVSQTGRRNLFDELVVDKDLFQCVSFIIPTLNSPDEEEFLYVDIKGPTHEFSKRNAVLVKNKESVVFVQTDKPVYKPGQSVKFRVVSMDKTLRPLNELLPLAYIEDPKKNRIMQWRDIKTENGLKQMSFSLAAEPIQGPYKIVVHKQSGVKEEHSFTVMEFVLPRFNVDLKVPNAISVNDEVLQVTVCGKYTYGKPVPGQVKISICHETEAGCKEVNSKLDNNGCSTQEVNITELQSKKRNYEVQLFHVNATVTEEGTGLEFNGYGTTKIERITNKLIFLKADSHFRHGIPFFVKVRLVDIKGDPIPNERVFIKAQVLGYTSATTTDQHGLAKFSIDTAGFSGSSLHIKVNHKGKDSCYFFYCMEERYASAEHVAYAVYSLSKSYIYLVKETSSILPCNQIHTVQAHFILKGDLGVLKELVFYYLVMAQGSIIQTGNHTHQVEPGEAPVKGNFDLEIPVEFSMAPMAKMLIYTILPDGEVIADSVNFEIEKCLRNKVDLSFSSSQSLPASQTRLQVTASPQSLCGLRAVDQSVLLLKPEDELSPSWIYNLPGMQHNKFIPSSSLSEDREDCILYSSWVAEKHTDWVPHGREKDVYRYVEDMDLKAFTNLKIKLPKICFDSAPMSGPRGKFDLAFSSEVSGTLQKGSSKRPQPEEPPREDPPPKDPLAETIRKYFPETWVWDIVTVNSTGVAEVEMTVPDTITEWKAGALCLSNDTGLGLSSVVPLQAFQPFFVEVSLPYSVVRGEAFMLKATVMNYLPTSMRMSVQLEASPDFTAVPVGDDHDSYCLSANGRHTSSWLVTPKSLGNVNFSVSVEAQQSSEPCGSEVATVPETGRKDTVVKVLIVEPEGIKQEHTFNSLFCASDAEISEKMSLVLPPTVVKDSARAHFSVMGDILSSAIKNTQNLLHMPYGCGEQNMVLFAPNIYVLKYLDKTQQLTQKIKTKALGFLRAGYQRELNYKHKDGSYSAFGDQNGEREGNTWLTAFVLKSFAQARAFIFIDESHITHAFTWLSQQQKDNGCFRSSGSLFHNDIKHPVVSKALSCLESSWKTIEQGRNANFVYTKALMAYAFALAGNQDKRNEILKSLDEEAIKEDNSIHWERPQKPRKSEHNLYKPQASSVEVEMNAYVVLARLTAQPAPSPEDLTLSRSTIMWLTKQQNSNGGFSSTQDTVVALDALSKYGAVTFSRRQKTSLVTIQSTGSFSQKFQVENSNCLLLQQVPLPDIPGDYTISVSGEGCVYAQTTLRYNMHLEKQQSAFALRVQTVPLTCNNPKGHNSFQISLEISYTGSRPASNMVIADVKMLSGFIPLKPTVKKLERLEHISRTEVSNNNVLLYLDQVTNQTLAFSFIIQQDISVRNLQPAIVKVYDYYETDEVAYAEYSSPCSSDKQNV
uniprot
proteins
function
FUNCTION: A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, for inhibition to be effective.
uniprot
proteins
mass_dalton
162382
uniprot
proteins
protein_family
Protease inhibitor I39 (alpha-2-macroglobulin) family
uniprot
proteins
pubmed
1840592
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1451
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins