Lyrm4
entrez
380840
canonical
uniprot
Q8K215
canonical
ensembl
ENSMUSG00000046573
resolver
ensp
ENSMUSP00000060779
resolver
enst
ENSMUST00000053265
resolver
genesymbol
Lyrm4
resolver
genesymbol_syn
Isd11
resolver
uniprot_entry
LYRM4_MOUSE
resolver
amino_acid_sequence
MAASSRAQVLDLYRAMMRESKHFSAYNYRMYAVRRIRDAFRENKNVKDPVEIQALVNKAKRDLEIIRRQVHIGQLYSTDKLIIENQEKPRT
uniprot
proteins
function
FUNCTION: Stabilizing factor, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with NDUFAB1, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU (By similarity). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). May also participates in the iron-sulfur protein biogenesis in the cytoplasm through its interaction with the cytoplasmic form of NFS1 (By similarity). {ECO:0000250|UniProtKB:Q9H1K1, ECO:0000250|UniProtKB:Q9HD34}.
uniprot
proteins
mass_dalton
10855
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; iron-sulfur cluster biosynthesis. {ECO:0000250|UniProtKB:Q9HD34}.
uniprot
proteins
protein_family
Complex I LYR family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21298097
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
25597503
uniprot
proteins
sequence_length
91
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q9HD34}. Nucleus {ECO:0000250|UniProtKB:Q9HD34}.
uniprot
proteins