MDM4
entrez
4194
canonical
uniprot
O15151
canonical
ensembl
ENSG00000198625
resolver
ensp
ENSP00000356150
resolver
ensp
ENSP00000356151
resolver
ensp
ENSP00000396840
resolver
ensp
ENSP00000478080
resolver
ensp
ENSP00000478581
resolver
ensp
ENSP00000482388
resolver
ensp
ENSP00000520980
resolver
ensp
ENSP00000550874
resolver
ensp
ENSP00000592737
resolver
ensp
ENSP00000629627
resolver
ensp
ENSP00000647196
resolver
enst
ENST00000470908
resolver
enst
ENST00000612738
resolver
enst
ENST00000614459
resolver
enst
ENST00000616250
resolver
enst
ENST00000922678
resolver
genesymbol
DKFZp781B1423
resolver
genesymbol
MDM4
resolver
genesymbol_syn
MDM4
resolver
genesymbol_syn
MDMX
resolver
hgnc
HGNC:6974
resolver
uniprot
A0A087WTR9
resolver
uniprot
A0A087WUE3
resolver
uniprot
A0A087WZ58
resolver
uniprot
A0ABJ7H8G1
resolver
uniprot
Q2M2Y2
resolver
uniprot
Q32SL2
resolver
uniprot
Q59FS6
resolver
uniprot
Q68DC0
resolver
uniprot
Q6GS18
resolver
uniprot
Q8IV83
resolver
uniprot_entry
A0A087WTR9_HUMAN
resolver
uniprot_entry
A0A087WUE3_HUMAN
resolver
uniprot_entry
A0A087WZ58_HUMAN
resolver
uniprot_entry
A0ABJ7H8G1_HUMAN
resolver
uniprot_entry
MDM4_HUMAN
resolver
uniprot_entry
Q59FS6_HUMAN
resolver
uniprot_entry
Q68DC0_HUMAN
resolver
uniprot_sec
Q2M2Y2
resolver
uniprot_sec
Q32SL2
resolver
uniprot_sec
Q6GS18
resolver
uniprot_sec
Q8IV83
resolver
amino_acid_sequence
MTSFSTSAQCSTSDSACRISPGQINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLATATTDAAQTLALAQDHSMDIPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHSREDEDLIENLAQDETSRLDLGFEEWDVAGLPWWFLGNLRSNYTPRSNGSTDLQTNQDVGTAIVSDTTDDLWFLNESVSEQLGVGIKVEAADTEQTSEEVGKVSDKKVIEVGKNDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSDITAIPEKENEGNDVPDCRRTISAPVVRPKDAYIKKENSKLFDPCNSVEFLDLAHSSESQETISSMGEQLDNLSEQRTDTENMEDCQNLLKPCSLCEKRPRDGNIIHGRTGHLVTCFHCARRLKKAGASCPICKKEIQLVIKVFIA
uniprot
proteins
disease_involvement
DISEASE: Bone marrow failure syndrome 6 (BMFS6) [MIM:618849]: A form of bone marrow failure syndrome, a heterogeneous group of life-threatening disorders characterized by hematopoietic defects in association with a range of variable extra-hematopoietic manifestations. BMFS6 is an autosomal dominant form characterized by intermittent neutropenia, lymphopenia, or anemia associated with hypocellular bone marrow, and increased susceptibility to cancer. {ECO:0000269|PubMed:32300648}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Contributes to p53/TP53 regulation (PubMed:32300648). Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding their transcriptional activation domains. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions. {ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:32300648}.
uniprot
proteins
mass_dalton
54864
uniprot
proteins
mutagenesis
MUTAGEN 437; /note="C->G: Fails to interact with MDM2."; /evidence="ECO:0000269|PubMed:10608892
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation at Ser-367 promotes interaction with YWHAG and subsequent ubiquitination and degradation. Phosphorylation at Ser-342 also induces ubiquitination and degradation but to a lower extent. {ECO:0000269|PubMed:16163388, ECO:0000269|PubMed:16511572, ECO:0000269|PubMed:19838211}.; PTM: Ubiquitinated and degraded by MDM2. Deubiquitination by USP2 on the other hand stabilizes the MDM4 protein. {ECO:0000269|PubMed:19838211}.
uniprot
proteins
protein_family
MDM2/MDM4 family
uniprot
proteins
pubmed
10608892
uniprot
proteins
pubmed
11840567
uniprot
proteins
pubmed
12761890
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16163388
uniprot
proteins
pubmed
16266988
uniprot
proteins
pubmed
16511572
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
19838211
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25384516
uniprot
proteins
pubmed
32300648
uniprot
proteins
pubmed
36897777
uniprot
proteins
pubmed
9226370
uniprot
proteins
sequence_length
490
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:36897777}. Cytoplasm {ECO:0000269|PubMed:36897777}.
uniprot
proteins