Q9CQK8
uniprot
Q9CQK8
canonical
amino_acid_sequence
MSYYQQQCNQPCRPPPVCPPPKCPEPCPPQVWPGPCRPVMCFEPCLPSVWPGPCRPVVCYEQCPPQPWQSTCPPVQFPPCQQK
uniprot
proteins
function
FUNCTION: Gut bactericidal protein that selectively kills Gram-positive bacteria by binding to negatively charged lipids on bacterial membranes, leading to bacterial membrane permeabilization and disruption (PubMed:34735226). Specifically binds lipids bearing negatively charged headgroups, such as phosphatidic acid, phosphatidylserine (PS), cardiolipin (CL), and phosphatidylinositol phosphates, but not to zwitterionic or neutral lipids (By similarity). Induced by type-2 cytokines in response to helminth infection and is required to protect against helminth-induced bacterial invasion of intestinal tissue (PubMed:34735226). May also be involved in the development of the cornified envelope of squamous epithelia; however, additional evidence is required to confirm this result in vivo (By similarity). {ECO:0000250|UniProtKB:P35326, ECO:0000269|PubMed:34735226}.
uniprot
proteins
mass_dalton
9408
uniprot
proteins
post_translational_modification
PTM: Forms five pairs of intrachain disulfide bonds. {ECO:0000250|UniProtKB:P35326}.
uniprot
proteins
protein_family
Cornifin (SPRR) family
uniprot
proteins
pubmed
12584609
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
34735226
uniprot
proteins
pubmed
9888996
uniprot
proteins
sequence_length
83
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:34735226}. Secreted, extracellular space {ECO:0000269|PubMed:34735226}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:34735226}. Note=Present in intestinal secretory epithelial cells and is secreted into the intestinal lumen. {ECO:0000269|PubMed:34735226}.
uniprot
proteins