Kdm3a
entrez
312440
canonical
uniprot
Q63679
canonical
ensembl
ENSRNOG00000007814
resolver
ensp
ENSRNOP00000041218
resolver
ensp
ENSRNOP00000110251
resolver
enst
ENSRNOT00000045279
resolver
genesymbol
Kdm3a
resolver
genesymbol_syn
Jhdm2a
resolver
genesymbol_syn
Jmjd1a
resolver
genesymbol_syn
Tsga
resolver
uniprot
D3ZLJ9
resolver
uniprot_entry
D3ZLJ9_RAT
resolver
uniprot_entry
KDM3A_RAT
resolver
amino_acid_sequence
MYKSLLDKAGLGSITSVRFLGDQQSVFVSKDLLKPIQDVNSLRLSLTDNQTVSKEFQALIVKHLDESHLLQGDKNLVGSEVRIYSLDPSTQWFSATVVHGNPSSKTLQVNCEEIPALKIVDPALIHVEVVHDNFVTCGNSTRIGAVKRKSSENNGSSVSKQAKSCSEVSPSMCPVQSVPTTVCKEILLGCTAATPSSNRQQNTPQAANSPPNIGAKLPQGCHKQSLPEEISSCLNTKSEVLRTKPDVCKAGLLSSKSSQVGAGDLKILSEPKGSCIQPKTNTDQESRLESTPQPVTGLTKECLVTKTSSKAELDNATAPELQKRLEHTASTPDGLSDKPEVEAGVTRLNSCSEKKVGPSDLGSQSQNLKETSVKVDHDSCCTRSSNKTQTPPARKSVLTDPDKLKKLQQSGEAFVQDDSCVNIVAQLPKCRECRLDSLRKDKDQQKDSPVFCRFFHFRRLQFNKHGVLRVEGFLTPNKYDSEAIGLWLPLTKNVVGTDLDTAKYILANIGDHFCQMVISEKEAMSTIEPHRQVAWKRAVKGVREMCDVCDTTIFNLHWVCPRCGFGVCVDCYRLKRKNCQQGAAYKTFSWIRCVKSQIHEPENLMPTQIIPGKALYDVGDIVHSVRAKWGIKANCPCSNRQFKLFSKPALKEDLKQASLSGEKPSLGTMVQQSSPVLEPAAVCGEAPSKPASNVKPICPANTSPLNWLADLTSGNVNKENKEKQLTMPILKNEIKCLPPLPPLNKSSTVLHTFNSTILTPVSNNNSGFLRNLLNSSTGKTENGLKNTPKILDDIFASLVQNKTSSDLSKRPQGLTIKPSILGFDTPHYWLCDNRLLCLQDPNNKSNWNVFRECWKQGQPVMVSGVHHKLNTELWKPESFRKEFGEQEVDLVNCRTNEIITGATVGDFWDGFEDVPNRLKNEKEKEPMVLKLKDWPPGEDFRDMMPSRFDDLMANIPLPEYTRRDGKLNLASRLPNYFVRPDLGPKMYNAYGLITPEDRKYGTTNLHLDVSDAANVMVYVGIPKGQCEQEEEVLRTIQDGDSDELTIKRFIEGKEKPGALWHIYAAKDTEKIREFLKKVSEEQGQENPADHDPIHDQSWYLDRSLRKRLYQEYGVQGWAIVQFLGDVVFIPAGAPHQVHNLYSCIKVAEDFVSPEHVKHCFWLTQEFRHLSQTHTNHEDKLQVKNVIYHAVKDAVAMLKAVNPVWANVNSSAHWR
uniprot
proteins
ec_number
1.14.11.65
uniprot
proteins
function
FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Directly regulates expression of PPARA and UCP1 and is involved in obesity resistance (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
135404
uniprot
proteins
protein_family
JHDM2 histone demethylase family
uniprot
proteins
pubmed
1793593
uniprot
proteins
sequence_length
1214
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Nuclear in round spermatids. When spermatids start to elongate, localizes to the cytoplasm where it forms distinct foci which disappear in mature spermatozoa (By similarity). {ECO:0000250}.
uniprot
proteins