Trpc6
entrez
22068
canonical
uniprot
Q61143
canonical
ensembl
ENSMUSG00000031997
resolver
ensp
ENSMUSP00000057965
resolver
ensp
ENSMUSP00000149686
resolver
ensp
ENSMUSP00000150193
resolver
ensp
ENSMUSP00000247708
resolver
ensp
ENSMUSP00000247709
resolver
enst
ENSMUST00000050433
resolver
enst
ENSMUST00000214596
resolver
enst
ENSMUST00000217462
resolver
genesymbol
Trpc6
resolver
genesymbol_syn
Trp6
resolver
genesymbol_syn
Trrp6
resolver
uniprot
A0A1L1SS04
resolver
uniprot
A0A1L1ST71
resolver
uniprot
B9EIW2
resolver
uniprot
Q3UZG1
resolver
uniprot
Q6NV56
resolver
uniprot
Q9Z2J1
resolver
uniprot_entry
A0A1L1SS04_MOUSE
resolver
uniprot_entry
A0A1L1ST71_MOUSE
resolver
uniprot_entry
Q3UZG1_MOUSE
resolver
uniprot_entry
Q6NV56_MOUSE
resolver
uniprot_entry
TRPC6_MOUSE
resolver
uniprot_sec
B9EIW2
resolver
uniprot_sec
Q9Z2J1
resolver
amino_acid_sequence
MSQSPRFVTRRGGSLKAAPGAGTRRNESQDYLLMDELGDDGYPQLPLPPYGYYPSFRGNENRLTHRRQTILREKGRRLANRGPAYMFNDHSTSLSIEEERFLDAAEYGNIPVVRKMLEECHSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRVGDALLLAISKGYVRIVEAILNHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHDVTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCTECSQKQKHDSFSHSRSRINAYKGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYRKLSMQCKDFVVGLLDLCRNTEEVEAILNGDAETRQPGDFGRPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYENLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWCAPCSKMGKILRGPFMKFVAHAASFTIFLGLLVMNAADRFEGTKLLPNETSTDNARQLFRMKTSCFSWMEMLIISWVIGMIWAECKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDLTKVTLGDNVKYYNLARIKWDPTDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIFGLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVEWKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLLYLLLKFKKWMCELIQGQKQGFQEDAEMNKRNEEKKFGISGSHEDLSKFSLDKNQLAHNKQSSTRSSEDYHLNSFSNPPRQYQKIMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLAELIRKLGERLSLEPKLEESRR
uniprot
proteins
function
FUNCTION: Non-selective, calcium-permeable cation channel (PubMed:9368034). Mediates calcium entry following G(q)-coupled receptor or receptor tyrosine kinase activation, which triggers phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositides and production of diacylglycerol (DAG) that directly activates TRPC6 (PubMed:22051675, PubMed:9368034). Does not appear to be activated by depletion of intracellular calcium stores (By similarity). Mediates depolarization of intrinsically photosensitive retinal ganglion cells (ipRGCs) in response to light-induced melanopsin (OPN4)-mediated phototransduction via G(q)-PLC signaling, likely by forming heteromeric TRPC6-TRPC7 channels (PubMed:22051675). {ECO:0000250|UniProtKB:Q9Y210, ECO:0000269|PubMed:22051675, ECO:0000269|PubMed:9368034}.
uniprot
proteins
mass_dalton
106681
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by FYN, leading to an increase of TRPC6 channel activity. {ECO:0000269|PubMed:14761972}.; PTM: N-glycosylated.
uniprot
proteins
protein_family
STrpC subfamily
uniprot
proteins
protein_family
TRPC6 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
pubmed
10050885
uniprot
proteins
pubmed
14761972
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22051675
uniprot
proteins
pubmed
8646775
uniprot
proteins
pubmed
9368034
uniprot
proteins
sequence_length
930
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9Y210}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 438..458; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 487..507; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 521..541; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 592..612; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 636..656; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 706..726; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins