Bdnf
entrez
12064
canonical
uniprot
P21237
canonical
ensembl
ENSMUSG00000048482
resolver
ensp
ENSMUSP00000057989
resolver
ensp
ENSMUSP00000106672
resolver
ensp
ENSMUSP00000106673
resolver
ensp
ENSMUSP00000106674
resolver
ensp
ENSMUSP00000106675
resolver
ensp
ENSMUSP00000106676
resolver
ensp
ENSMUSP00000106678
resolver
ensp
ENSMUSP00000106679
resolver
ensp
ENSMUSP00000106680
resolver
ensp
ENSMUSP00000135762
resolver
genesymbol
Bdnf
resolver
uniprot
A2AII2
resolver
uniprot
Q541P3
resolver
uniprot
Q8CCH9
resolver
uniprot_entry
BDNF_MOUSE
resolver
uniprot_entry
Q541P3_MOUSE
resolver
uniprot_sec
A2AII2
resolver
uniprot_sec
Q8CCH9
resolver
amino_acid_sequence
MTILFLTMVISYFGCMKAAPMKEVNVHGQGNLAYPGVRTHGTLESVNGPRAGSRGLTTTSLADTFEHVIEELLDEDQKVRPNEENHKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAANMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQYFYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCTLTIKRGR
uniprot
proteins
function
FUNCTION: Important signaling molecule that activates signaling cascades downstream of NTRK2 (PubMed:27457814). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability (PubMed:15486301, PubMed:17023662, PubMed:27457814, PubMed:29909994, PubMed:8139657). {ECO:0000269|PubMed:15486301, ECO:0000269|PubMed:17023662, ECO:0000269|PubMed:27457814, ECO:0000269|PubMed:29909994, ECO:0000269|PubMed:8139657}.; FUNCTION: [Neurotrophic factor BDNF precursor form]: Important signaling molecule that activates signaling cascades downstream of NTRK2 (PubMed:27457814). Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2 (PubMed:24908487, PubMed:29909994). Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD) (PubMed:27457814). Binding to NGFR and SORCS2 promotes neuronal apoptosis (PubMed:24908487). Promotes neuronal growth cone collapse (PubMed:24908487, PubMed:27457814). {ECO:0000269|PubMed:24908487, ECO:0000269|PubMed:27457814, ECO:0000269|PubMed:29909994}.
uniprot
proteins
mass_dalton
28123
uniprot
proteins
mutagenesis
MUTAGEN 68; /note="V->M: Reduced hippocampal volume, dendritic complexity and context-dependent memory. Decreased density of dendritic mushroom spines and synapses. Impaired fear extinction. Increased anxiety-related behaviors."; /evidence="ECO:0000269|PubMed:17023662, ECO:0000269|PubMed:29909994"; MUTAGEN 130; /note="R->K: Forms homodimers processed at L-112 that seem more stable than the wild-type."; /evidence="ECO:0000269|PubMed:7957235
uniprot
proteins
post_translational_modification
PTM: [Neurotrophic factor BDNF precursor form]: N-glycosylated and glycosulfated, contrary to mature BDNF. {ECO:0000250|UniProtKB:P23560}.; PTM: Mature BDNF is produced by proteolytic removal of the propeptide, catalyzed by a FURIN family member. In addition, the precursor form is proteolytically cleaved within the propeptide, but this is not an obligatory intermediate for the production of mature BDNF (By similarity). Can be converted into mature BDNF by plasmin (PLG) (PubMed:15486301). {ECO:0000250|UniProtKB:P23560, ECO:0000269|PubMed:15486301}.
uniprot
proteins
protein_family
NGF-beta family
uniprot
proteins
pubmed
15486301
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17023662
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
2369898
uniprot
proteins
pubmed
23785138
uniprot
proteins
pubmed
24908487
uniprot
proteins
pubmed
27457814
uniprot
proteins
pubmed
28111162
uniprot
proteins
pubmed
29909994
uniprot
proteins
pubmed
7957235
uniprot
proteins
pubmed
8139657
uniprot
proteins
sequence_length
249
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P23560}.; SUBCELLULAR LOCATION: [Neurotrophic factor BDNF precursor form]: Secreted {ECO:0000250|UniProtKB:P23560}. Note=A proportion of BDNF is secreted as immature precursor (proBDNF). {ECO:0000250|UniProtKB:P23560}.
uniprot
proteins