Dvl2
entrez
13543
canonical
uniprot
Q60838
canonical
ensembl
ENSMUSG00000020888
resolver
ensp
ENSMUSP00000019362
resolver
ensp
ENSMUSP00000099635
resolver
ensp
ENSMUSP00000140073
resolver
enst
ENSMUST00000019362
resolver
enst
ENSMUST00000102575
resolver
enst
ENSMUST00000190940
resolver
genesymbol
Dvl2
resolver
uniprot
Q7TN14
resolver
uniprot_entry
DVL2_MOUSE
resolver
uniprot_sec
Q7TN14
resolver
amino_acid_sequence
MAGSSAGGGGVGETKVIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWLVSSDTPQPEVAPPAHESRTELVPPPPPLPPLPPERTSGIGDSRPPSFHPNVSSSHENLEPETETESVVSLRRDRPRRRDSSEHGAGGHRPGGPSRLERHLAGYESSSTLMTSELESTSLGDSDEDDTMSRFSSSTEQSSASRLLKRHRRRRKQRPPRMERTSSFSSVTDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDMNFENMSNDDAVRVLRDIVHKPGPIVLTVAKCWDPSPQAYFTLPRNEPIQPIDPAAWVSHSAALTGAFPAYPGSSSMSTITSGSSLPDGCEGRGLSVHMDMASVTKAMAAPESGLEVRDRMWLKITIPNAFLGSDVVDWLYHHVEGFPERREARKYASGLLKAGLIRHTVNKITFSEQCYYVFGDLSGGCESYLVNLSLNDNDGSSGASDQDTLAPLPGATPWPLLPTFSYQYPAPHPYSPQPPPYHELSSYTYGGGSASSQHSEGSRSSGSTRSDGGAGRTGRPEERAPESKSGSGSESELSSRGGSLRRGGEPGGTGDGGPPPSRGSTGAPPNLRALPGLHPYGAPSGMALPYNPMMVVMMPPPPPPVSTAVQPPGAPPVRDLGSVPPELTASRQSFHMAMGNPSEFFVDVM
uniprot
proteins
function
FUNCTION: Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Participates both in canonical and non-canonical Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. {ECO:0000269|PubMed:17199046, ECO:0000269|PubMed:20947020, ECO:0000269|PubMed:21189423}.
uniprot
proteins
mass_dalton
78861
uniprot
proteins
mutagenesis
MUTAGEN 15; /note="K->A: Reduces oligomerization. Reduces activation of Wnt signaling."; /evidence="ECO:0000269|PubMed:21189423"; MUTAGEN 17; /note="I->A: Reduces oligomerization. Abolishes interaction with DIXDC1. Reduces activation of Wnt signaling."; /evidence="ECO:0000269|PubMed:21189423"; MUTAGEN 27; /note="Y->D: Loss of oligomerization. Abolishes interaction with DIXDC1. Abolishes activation of Wnt signaling."; /evidence="ECO:0000269|PubMed:21189423"; MUTAGEN 56; /note="F->H: Reduces oligomerization. Strongly reduced activation of Wnt signaling."; /evidence="ECO:0000269|PubMed:21189423"; MUTAGEN 61; /note="D->A: Reduces oligomerization. Reduces activation of Wnt signaling."; /evidence="ECO:0000269|PubMed:21189423"; MUTAGEN 63; /note="D->A: Reduces oligomerization. Reduces activation of Wnt signaling."; /evidence="ECO:0000269|PubMed:21189423"; MUTAGEN 64; /note="F->A: Reduces oligomerization. Reduces activation of Wnt signaling."; MUTAGEN 65; /note="G->D: Loss of oligomerization. Abolishes activation of Wnt signaling."; /evidence="ECO:0000269|PubMed:21189423"; MUTAGEN 66; /note="V->D: Reduces oligomerization. Reduces activation of Wnt signaling."; /evidence="ECO:0000269|PubMed:21189423"; MUTAGEN 68; /note="K->A: Loss of oligomerization. Strongly reduced activation of Wnt signaling."; /evidence="ECO:0000269|PubMed:21189423"; MUTAGEN 84; /note="R->A: Strongly reduced interaction with DIXDC1.
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CSNK1D. WNT3A induces DVL2 phosphorylation by CSNK1E and MARK kinases. {ECO:0000250|UniProtKB:O14641}.; PTM: Ubiquitinated via 'Lys-63'-linked polyubiquitin chains; leading to its autophagy-mediated degradation. {ECO:0000250|UniProtKB:O14641}.
uniprot
proteins
protein_family
DSH family
uniprot
proteins
pubmed
15262978
uniprot
proteins
pubmed
15456783
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17199046
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20947020
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21189423
uniprot
proteins
pubmed
23708998
uniprot
proteins
pubmed
25823377
uniprot
proteins
pubmed
27214281
uniprot
proteins
pubmed
31073040
uniprot
proteins
pubmed
8887313
uniprot
proteins
sequence_length
736
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17199046, ECO:0000269|PubMed:20947020}; Peripheral membrane protein {ECO:0000269|PubMed:20947020}; Cytoplasmic side {ECO:0000269|PubMed:20947020}. Cytoplasm, cytosol {ECO:0000269|PubMed:21189423}. Cytoplasmic vesicle {ECO:0000269|PubMed:17199046, ECO:0000269|PubMed:21189423}. Nucleus {ECO:0000250|UniProtKB:O14641}. Note=Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization (PubMed:21189423). Localizes to cytoplasmic puncta. Interaction with FOXK1 and FOXK2 induces nuclear translocation (By similarity). {ECO:0000250|UniProtKB:O14641, ECO:0000269|PubMed:21189423}.
uniprot
proteins