GAS1
entrez
2619
canonical
uniprot
P54826
canonical
ensembl
ENSG00000180447
resolver
ensp
ENSP00000298743
resolver
enst
ENST00000298743
resolver
genesymbol
GAS1
resolver
hgnc
HGNC:4165
resolver
uniprot
B9EGM4
resolver
uniprot
Q6B086
resolver
uniprot_entry
GAS1_HUMAN
resolver
uniprot_sec
B9EGM4
resolver
uniprot_sec
Q6B086
resolver
amino_acid_sequence
MVAALLGGGGEARGGTVPGAWLCLMALLQLLGSAPRGSGLAHGRRLICWQALLQCQGEPECSYAYNQYAEACAPVLAQHGGGDAPGAAAAAFPASAASFSSRWRCPSHCISALIQLNHTRRGPALEDCDCAQDENCKSTKRAIEPCLPRTSGGGAGGPGAGGVMGCTEARRRCDRDSRCNLALSRYLTYCGKVFNGLRCTDECRTVIEDMLAMPKAALLNDCVCDGLERPICESVKENMARLCFGAELGNGPGSSGSDGGLDDYYDEDYDDEQRTGGAGGEQPLDDDDGVPHPPRPGSGAAASGGRGDLPYGPGRRSSGGGGRLAPRGAWTPLASILLLLLGPLF
uniprot
proteins
function
FUNCTION: Coreceptor required for sonic hedgehog (SHH) handoff to its receptor: binds to the dually lipid-modified Sonic hedgehog protein N-product (ShhN) downstream of the CDON-BOC heterodimer and directly transfers ShhN to its patched receptor (PTCH1 or PTCH2), followed by activation of the smoothened signaling pathway (PubMed:35231446). Specifically recognizes and binds palmitate and cholesterol moieties in dually lipid-modified ShhN (PubMed:35231446). Binds 20(S)-hydroxycholesterol (20(S)-OHC) (By similarity). Acts as a growth arrest protein involved in growth suppression by blocking entry to S phase (PubMed:8127893). {ECO:0000250|UniProtKB:Q01721, ECO:0000269|PubMed:35231446, ECO:0000269|PubMed:8127893}.
uniprot
proteins
mass_dalton
35693
uniprot
proteins
mutagenesis
MUTAGEN 49..53; /note="WQALL->AQALA: Reduced binding to the dually lipid-modified Sonic hedgehog protein N-product (ShhN)."; /evidence="ECO:0000269|PubMed:35231446
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
35231446
uniprot
proteins
pubmed
8127893
uniprot
proteins
sequence_length
345
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8127893}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q01721}; Extracellular side {ECO:0000250|UniProtKB:Q01721}.
uniprot
proteins