GDPD2
entrez
54857
canonical
uniprot
Q9HCC8
canonical
ensembl
ENSG00000130055
resolver
ensp
ENSP00000363503
resolver
ensp
ENSP00000414019
resolver
ensp
ENSP00000444601
resolver
ensp
ENSP00000445982
resolver
genesymbol
GDPD2
resolver
genesymbol_syn
GDE3
resolver
genesymbol_syn
OBDPF
resolver
hgnc
HGNC:25974
resolver
uniprot
B4DRH4
resolver
uniprot
B4DVC9
resolver
uniprot
Q9NXJ6
resolver
uniprot_entry
GDE3_HUMAN
resolver
uniprot_sec
B4DRH4
resolver
uniprot_sec
B4DVC9
resolver
uniprot_sec
Q9NXJ6
resolver
amino_acid_sequence
MAESPGCCSVWARCLHCLYSCHWRKCPRERMQTSKCDCIWFGLLFLTFLLSLSWLYIGLVLLNDLHNFNEFLFRRWGHWMDWSLAFLLVISLLVTYASLLLVLALLLRLCRQPLHLHSLHKVLLLLIMLLVAAGLVGLDIQWQQEWHSLRVSLQATAPFLHIGAAAGIALLAWPVADTFYRIHRRGPKILLLLLFFGVVLVIYLAPLCISSPCIMEPRDLPPKPGLVGHRGAPMLAPENTLMSLRKTAECGATVFETDVMVSSDGVPFLMHDEHLSRTTNVASVFPTRITAHSSDFSWTELKRLNAGSWFLERRPFWGAKPLAGPDQKEAESQTVPALEELLEEAAALNLSIMFDLRRPPQNHTYYDTFVIQTLETVLNARVPQAMVFWLPDEDRANVQRRAPGMRQIYGRQGGNRTERPQFLNLPYQDLPLLDIKALHKDNVSVNLFVVNKPWLFSLLWCAGVDSVTTNDCQLLQQMRYPIWLITPQTYLIIWVITNCVSTMLLLWTFLLQRRFVKKRGKTGLETAVLLTRINNFMME
uniprot
proteins
ec_number
3.1.4.-
uniprot
proteins
ec_number
3.1.4.43
uniprot
proteins
function
FUNCTION: Calcium-dependent ecto-phospholipase C that cleaves the phosphodiester bond between the glycerol backbone and phosphate group of glycerophospholipids at the cell surface, regulating multiple signaling pathways (PubMed:28849762, PubMed:32629025, PubMed:32917725). Substrates include GPI-anchored proteins, which are released from the membrane upon cleavage of the inositol-phosphate linkage. For example, cleavage and release of UPAR/PLAUR regulates cell-matrix adhesion and extracellular matrix remodeling (PubMed:28849762). Also cleaves the glycosylphosphatidylinositol (GPI) anchor of metalloproteases TRABD2A and TRABD2B, releasing them from the plasma membrane. This release modulates their regulation of Wnt signaling (PubMed:35182431). Also hydrolyzes lysophosphatidylinositol (LPI) to monoacylglycerol and inositol-1-phosphate. Converts 2-arachidonoyl-LPI, the endogenous GPR55 agonist, into 2-arachidonoylglycerol (2-AG), an endocannabinoid that activates CNR1/CNR2. Thereby, acts as a switch redirecting signaling from GPR55 to CNR1/CNR2 within the endocannabinoid system that could alternatively regulate osteoblast proliferation and differentiation (PubMed:32629025, PubMed:32917725). Can also cleave glycerophosphoinositol to glycerol and inositol-1-phosphate in vitro (By similarity). May also play a role in remodeling of the actin cytoskeleton (By similarity). {ECO:0000250|UniProtKB:Q9ESM6, ECO:0000269|PubMed:28849762, ECO:0000269|PubMed:32629025, ECO:0000269|PubMed:32917725, ECO:0000269|PubMed:35182431}.
uniprot
proteins
mass_dalton
61729
uniprot
proteins
mutagenesis
MUTAGEN 229; /note="H->A: Loss of GPI anchor phospholipase C activity."; /evidence="ECO:0000269|PubMed:28849762"; MUTAGEN 230; /note="R->A: Loss of lysophosphatidylinositol phospholipase C activity."; /evidence="ECO:0000269|PubMed:32917725
uniprot
proteins
protein_family
Glycerophosphoryl diester phosphodiesterase family
uniprot
proteins
pubmed
12933806
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
28849762
uniprot
proteins
pubmed
32629025
uniprot
proteins
pubmed
32917725
uniprot
proteins
pubmed
35182431
uniprot
proteins
sequence_length
539
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:32917725, ECO:0000269|PubMed:35182431}; Multi-pass membrane protein {ECO:0000305|PubMed:32917725}. Note=Colocalizes with the actin cytoskeleton. {ECO:0000250|UniProtKB:Q9ESM6}.
uniprot
proteins
transmembrane_region
TRANSMEM 39..59; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 86..106; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 122..142; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 155..175; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 189..209; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 491..511; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins