Dazap2
entrez
23994
canonical
uniprot
Q9DCP9
canonical
ensembl
ENSMUSG00000000346
resolver
ensp
ENSMUSP00000000356
resolver
enst
ENSMUST00000000356
resolver
genesymbol
Dazap2
resolver
genesymbol_syn
Prtb
resolver
uniprot
O88675
resolver
uniprot
Q3UVI4
resolver
uniprot_entry
DAZP2_MOUSE
resolver
uniprot_sec
O88675
resolver
uniprot_sec
Q3UVI4
resolver
amino_acid_sequence
MNSKGQYPTQPTYPVQPPGNPVYPQTLHLPQAPPYTDAPPAYSELYRPSFVHPGAATVPTMSAAFPGASLYLPMAQSVAVGPLGSTIPMAYYPVGPIYPPGSAVLVEGGYDAGARFGAGATAGNIPPPPPGCPPNAAQLAVMQGANVLVTQRKGNFFMGGSDGGYTIW
uniprot
proteins
function
FUNCTION: In unstressed cells, promotes SIAH1-mediated polyubiquitination and degradation of the serine/threonine-protein kinase HIPK2, probably by acting as a loading factor that potentiates complex formation between HIPK2 and ubiquitin ligase SIAH1 (By similarity). In response to DNA damage, localizes to the nucleus following phosphorylation by HIPK2 and modulates the expression of a subset of TP53/p53 target genes by binding to TP53 at target gene promoters (By similarity). This limits the expression of a number of cell death-mediating TP53 target genes, reducing DNA damage-induced cell death (By similarity). Enhances the binding of transcription factor TCF7L2/TCF4, a Wnt signaling pathway effector, to the promoters of target genes (PubMed:19304756). Plays a role in stress granule formation (By similarity). {ECO:0000250|UniProtKB:Q15038, ECO:0000269|PubMed:19304756}.
uniprot
proteins
mass_dalton
17289
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by SMURF2, leading to proteasomal degradation. Ubiquitinated by NEDD4, leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q15038}.; PTM: Following DNA damage, phosphorylated by HIPK2 which promotes DAZAP2 localization to the nucleus, reduces interaction of DAZAP2 with HIPK2 and SIAH1, and prevents DAZAP2-dependent ubiquitination of HIPK2 by E3 ubiquitin-protein ligase SIAH1 and subsequent HIPK2 proteasomal degradation. {ECO:0000250|UniProtKB:Q15038}.
uniprot
proteins
pubmed
10373015
uniprot
proteins
pubmed
11787059
uniprot
proteins
pubmed
14530442
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19304756
uniprot
proteins
sequence_length
168
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q15038}. Nucleus {ECO:0000250|UniProtKB:Q15038}. Nucleus speckle {ECO:0000250|UniProtKB:Q15038}. Nucleus, nuclear body {ECO:0000250|UniProtKB:Q15038}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:Q15038}. Note=Predominantly nuclear in macrophages, stimulation of IL17RB with its ligand IL17E induces accumulation in the cytoplasm (By similarity). Predominantly cytoplasmic when unphosphorylated and localizes to the nucleus following phosphorylation by HIPK2 (By similarity). Localizes to stress granules under cellular stress conditions (By similarity). {ECO:0000250|UniProtKB:Q15038}.
uniprot
proteins