Abcg2
entrez
26357
canonical
uniprot
Q7TMS5
canonical
ensembl
ENSMUSG00000029802
resolver
ensp
ENSMUSP00000031822
resolver
ensp
ENSMUSP00000109933
resolver
ensp
ENSMUSP00000291026
resolver
ensp
ENSMUSP00000291027
resolver
ensp
ENSMUSP00000291028
resolver
ensp
ENSMUSP00000291033
resolver
ensp
ENSMUSP00000340900
resolver
ensp
ENSMUSP00000355370
resolver
enst
ENSMUST00000031822
resolver
enst
ENSMUST00000114294
resolver
genesymbol
Abcg2
resolver
genesymbol_syn
Abcp
resolver
genesymbol_syn
Bcrp1
resolver
uniprot
A0A0R4J0B6
resolver
uniprot
Q9R004
resolver
uniprot
Q9Z1T0
resolver
uniprot_entry
A0A0R4J0B6_MOUSE
resolver
uniprot_entry
ABCG2_MOUSE
resolver
uniprot_sec
Q9R004
resolver
uniprot_sec
Q9Z1T0
resolver
activity_regulation
ACTIVITY REGULATION: Specifically inhibited by the fungal toxin fumitremorgin C and Ko143. {ECO:0000269|PubMed:12477054}.
uniprot
proteins
amino_acid_sequence
MSSSNDHVLVPMSQRNNNGLPRTNSRAVRTLAEGDVLSFHHITYRVKVKSGFLVRKTVEKEILSDINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPKGLSGDVLINGAPQPAHFKCCSGYVVQDDVVMGTLTVRENLQFSAALRLPTTMKNHEKNERINTIIKELGLEKVADSKVGTQFIRGISGGERKRTSIGMELITDPSILFLDEPTTGLDSSTANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGKLVFHGPAQKALEYFASAGYHCEPYNNPADFFLDVINGDSSAVMLNREEQDNEANKTEEPSKGEKPVIENLSEFYINSAIYGETKAELDQLPGAQEKKGTSAFKEPVYVTSFCHQLRWIARRSFKNLLGNPQASVAQLIVTVILGLIIGAIYFDLKYDAAGMQNRAGVLFFLTTNQCFSSVSAVELFVVEKKLFIHEYISGYYRVSSYFFGKVMSDLLPMRFLPSVIFTCVLYFMLGLKKTVDAFFIMMFTLIMVAYTASSMALAIATGQSVVSVATLLMTIAFVFMMLFSGLLVNLRTIGPWLSWLQYFSIPRYGFTALQYNEFLGQEFCPGFNVTDNSTCVNSYAICTGNEYLINQGIELSPWGLWKNHVALACMIIIFLTIAYLKLLFLKKYS
uniprot
proteins
ec_number
7.6.2.2
uniprot
proteins
function
FUNCTION: Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes a wide variety of physiological compounds, dietary toxins and xenobiotics from cells (PubMed:10485464, PubMed:12429862, PubMed:12477054, PubMed:17145775, PubMed:30042379). Involved in porphyrin homeostasis, mediating the export of protoporphyrin IX (PPIX) from both mitochondria to cytosol and cytosol to extracellular space, it also functions in the cellular export of heme (PubMed:12429862, PubMed:15044468). Also mediates the efflux of sphingosine-1-P from cells (By similarity). Acts as a urate exporter functioning in both renal and extrarenal urate excretion (By similarity). In kidney, it also functions as a physiological exporter of the uremic toxin indoxyl sulfate (PubMed:30042379). Also involved in the excretion of steroids like estrone 3-sulfate/E1S, 3beta-sulfooxy-androst-5-en-17-one/DHEAS, and other sulfate conjugates (By similarity). Mediates the secretion of the vitamins riboflavin and biotin into milk (PubMed:17145775). Involved in the excretion of the riboflavin-derived compound lumichrome into the intestinal lumen and in its secretion into milk (PubMed:39337371). Extrudes pheophorbide a, a phototoxic porphyrin catabolite of chlorophyll, reducing its bioavailability (PubMed:12429862). Plays an important role in the exclusion of xenobiotics from the brain (PubMed:10485464). It confers to cells a resistance to multiple drugs and other xenobiotics including mitoxantrone, pheophorbide, camptothecin, methotrexate, azidothymidine, and the anthracyclines daunorubicin and doxorubicin, through the control of their efflux (PubMed:12477054). In placenta, it limits the penetration of drugs from the maternal plasma into the fetus (PubMed:12429862). May play a role in early stem cell self-renewal by blocking differentiation (Probable). In inflammatory macrophages, exports itaconate from the cytosol to the extracellular compartment and limits the activation of TFEB-dependent lysosome biogenesis involved in antibacterial innate immune response (PubMed:39116875). Operates at apical membranes of polarized cells such as hepatocytes and intestinal epithelial cells, where it may contribute to the efflux of conjugated substrates from intestine and liver into the intestinal lumen as well as their enterohepatic recycling. Can transport estrogen and androgen substrates conjugated with glucuronate or sulfate at C-3, C-16 and C-17 positions. Among androgen glucuronates, appears to selectively transport dihydrotestosterone-17-glucuronate while displaying no transporter activity toward testosterone, androsterone and etiocholanolone glucuronates. {ECO:0000250|UniProtKB:Q9UNQ0, ECO:0000269|PubMed:10485464, ECO:0000269|PubMed:12429862, ECO:0000269|PubMed:12477054, ECO:0000269|PubMed:15044468, ECO:0000269|PubMed:17145775, ECO:0000269|PubMed:30042379, ECO:0000269|PubMed:39116875, ECO:0000269|PubMed:39337371, ECO:0000305|PubMed:11533706}.
uniprot
proteins
mass_dalton
72978
uniprot
proteins
mutagenesis
MUTAGEN 210; /note="E->Q: Loss of ATP-dependent itaconate export resulting in itaconate cytosolic accumulation."; /evidence="ECO:0000269|PubMed:39116875
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. Glycosylation-deficient ABCG2 is normally expressed and functional. {ECO:0000250|UniProtKB:Q9UNQ0}.; PTM: Phosphorylated. Phosphorylation may regulate the localization to the plasma membrane, the homooligomerization and therefore, the activity of the transporter. {ECO:0000250|UniProtKB:Q9UNQ0}.
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCG family
uniprot
proteins
protein_family
Eye pigment precursor importer (TC 3.A.1.204) subfamily
uniprot
proteins
pubmed
10485464
uniprot
proteins
pubmed
11036110
uniprot
proteins
pubmed
11533706
uniprot
proteins
pubmed
12429862
uniprot
proteins
pubmed
12477054
uniprot
proteins
pubmed
15044468
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17145775
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30042379
uniprot
proteins
pubmed
39116875
uniprot
proteins
pubmed
39337371
uniprot
proteins
pubmed
9850061
uniprot
proteins
sequence_length
657
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9UNQ0}; Multi-pass membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:12429862}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q9UNQ0}; Multi-pass membrane protein {ECO:0000255}. Note=Enriched in membrane lipid rafts. {ECO:0000250|UniProtKB:Q9UNQ0}.
uniprot
proteins
transmembrane_region
TRANSMEM 394..414; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 429..449; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 478..498; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 507..527; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 536..556; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 633..653; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins