Slc28a2
entrez
60423
canonical
uniprot
Q62773
canonical
ensembl
ENSRNOG00000028668
resolver
ensp
ENSRNOP00000024658
resolver
enst
ENSRNOT00000024658
resolver
genesymbol
Slc28a2
resolver
genesymbol_syn
Cnt2
resolver
genesymbol_syn
Spnt
resolver
uniprot
F1LN73
resolver
uniprot
Q9QWI3
resolver
uniprot_entry
F1LN73_RAT
resolver
uniprot_entry
S28A2_RAT
resolver
uniprot_sec
Q9QWI3
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by formycin B, partially inhibited by purine analog ara-A. {ECO:0000269|PubMed:7775409}.
uniprot
proteins
amino_acid_sequence
MAKSEGRKSASQDTSENGMENPGLELMEVGNLEQGKTLEEVTQGHSLKDGLGHSSLWRRILQPFTKARSFYQRHAGLFKKILLGLLCLAYAAYLLAACILNFRRALALFVITCLVIFILACHFLKKFFAKKSIRCLKPLKNTRLRLWLKRVFMGAAVVGLILWLALDTAQRPEQLISFAGICMFILILFACSKHHSAVSWRTVFWGLGLQFVFGILVIRTEPGFNAFQWLGDQIQIFLAYTVEGSSFVFGDTLVQSVFAFQSLPIIIFFGCVMSILYYLGLVQWVIQKIAWFLQITMGTTAAETLAVAGNIFVGMTEAPLLIRPYLADMTLSEIHAVMTGGFATIAGTVLGAFISFGIDASSLISASVMAAPCALALSKLVYPEVEESKFKSKEGVKLPRGEERNILEAASNGATDAIALVANVAANLIAFLAVLAFINSTLSWLGEMVDIHGLTFQVICSYVLRPMVFMMGVQWADCPLVAEIVGVKFFINEFVAYQQLSQYKNKRLSGVEEWINGEKQWISVKAEIIATFSLCGFANLTSIGITLGGLTSMVPQRKSDLCKLVVRALFTGACVSFISACMAGILYVPRGAETDCVSFLNTNFTNRTYETYVCCRELFQSTLLNGTNMPSFSGPWQDKESSLRNLAKCCDLYTSTVCA
uniprot
proteins
function
FUNCTION: Sodium-dependent and purine-selective (PubMed:1315767, PubMed:7775409, PubMed:8967974). Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine) (PubMed:1315767, PubMed:7775409, PubMed:8967974). Accepts purine, analogs of purine nucleosides and uridine, and exhibits high affinity for adenosine (PubMed:7775409). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (By similarity). {ECO:0000250|UniProtKB:O43868, ECO:0000269|PubMed:1315767, ECO:0000269|PubMed:7775409, ECO:0000269|PubMed:8967974}.
uniprot
proteins
mass_dalton
72615
uniprot
proteins
protein_family
Concentrative nucleoside transporter (CNT) (TC 2.A.41) family
uniprot
proteins
pubmed
1315767
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7775409
uniprot
proteins
pubmed
8967974
uniprot
proteins
sequence_length
659
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:O43868}; Multi-pass membrane protein {ECO:0000255}. Apicolateral cell membrane {ECO:0000250|UniProtKB:O43868}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 81..101; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 105..124; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 149..167; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 173..193; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 201..221; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 234..254; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 261..281; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 296..315; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 337..356; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 363..382; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 424..444; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 455..475; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 530..550; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 568..588; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins