Fto
entrez
26383
canonical
uniprot
Q8BGW1
canonical
ensembl
ENSMUSG00000055932
resolver
ensp
ENSMUSP00000068380
resolver
ensp
ENSMUSP00000244336
resolver
genesymbol
Fto
resolver
genesymbol_syn
Kiaa1752
resolver
uniprot
Q3TTZ5
resolver
uniprot
Q6ZPI7
resolver
uniprot
Q8BR68
resolver
uniprot
Q8CB66
resolver
uniprot
Q8R250
resolver
uniprot
Q9QZ13
resolver
uniprot_entry
FTO_MOUSE
resolver
uniprot_sec
Q3TTZ5
resolver
uniprot_sec
Q6ZPI7
resolver
uniprot_sec
Q8BR68
resolver
uniprot_sec
Q8CB66
resolver
uniprot_sec
Q8R250
resolver
uniprot_sec
Q9QZ13
resolver
activity_regulation
ACTIVITY REGULATION: Activated by ascorbate (PubMed:17991826). Inhibited by N-oxalylglycine, fumarate and succinate (PubMed:17991826). {ECO:0000269|PubMed:17991826}.
uniprot
proteins
amino_acid_sequence
MKRVQTAEEREREAKKLRLLEELEDTWLPYLTPKDDEFYQQWQLKYPKLVFREAGSIPEELHKEVPEAFLTLHKHGCLFRDVVRIQGKDVLTPVSRILIGDPGCTYKYLNTRLFTVPWPVKGCTVKYTEAEIAAACQTFLKLNDYLQVETIQALEELAVREKANEDAVPLCMAEFPRAGVGPSCDDEVDLKSRAAYNVTLLNFMDPQKMPYLKEEPYFGMGKMAVSWHHDENLVDRSAVAVYSYSCEGSEDESEDESSFEGRDPDTWHVGFKISWDIETPGLTIPLHQGDCYFMLDDLNATHQHCVLAGSQPRFSSTHRVAECSTGTLDYILERCQLALQNVLNDSDDGDVSLKSFDPAVLKQGEEIHNEVEFEWLRQFWFQGNRYKLCTDWWCEPMTHLEGLWKKMESMTNAVLREVKREGLPVEQRSEILSAILVPLTVRQNLRKEWHARCQSRVVRTLPVQQKPDCRPYWEKDDPSMPLPFDLTDVVSELRGQLLEARS
uniprot
proteins
ec_number
1.14.11.-
uniprot
proteins
ec_number
1.14.11.53
uniprot
proteins
function
FUNCTION: RNA demethylase that mediates oxidative demethylation of different RNA species, such as mRNAs, tRNAs and snRNAs, and acts as a regulator of fat mass, adipogenesis and energy homeostasis (PubMed:17991826, PubMed:18775698, PubMed:28002401). Specifically demethylates N(6)-methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:28002401). M6A demethylation by FTO affects mRNA expression and stability (By similarity). Also able to demethylate m6A in U6 small nuclear RNA (snRNA) (By similarity). Mediates demethylation of N(6),2'-O-dimethyladenosine cap (m6A(m)), by demethylating the N(6)-methyladenosine at the second transcribed position of mRNAs and U6 snRNA (PubMed:28002401). Demethylation of m6A(m) in the 5'-cap by FTO affects mRNA stability by promoting susceptibility to decapping (By similarity). Also acts as a tRNA demethylase by removing N(1)-methyladenine from various tRNAs (By similarity). Has no activity towards 1-methylguanine (By similarity). Has no detectable activity towards double-stranded DNA (By similarity). Also able to repair alkylated DNA and RNA by oxidative demethylation: demethylates single-stranded RNA containing 3-methyluracil, single-stranded DNA containing 3-methylthymine and has low demethylase activity towards single-stranded DNA containing 1-methyladenine or 3-methylcytosine (PubMed:17991826, PubMed:18775698). Ability to repair alkylated DNA and RNA is however unsure in vivo (PubMed:17991826, PubMed:18775698). Involved in the regulation of fat mass, adipogenesis and body weight, thereby contributing to the regulation of body size and body fat accumulation (PubMed:19234441, PubMed:19680540, PubMed:21076408, PubMed:23300482, PubMed:23817550). Involved in the regulation of thermogenesis and the control of adipocyte differentiation into brown or white fat cells (PubMed:19234441, PubMed:19680540). Regulates activity of the dopaminergic midbrain circuitry via its ability to demethylate m6A in mRNAs (PubMed:23817550). {ECO:0000250|UniProtKB:Q9C0B1, ECO:0000269|PubMed:17991826, ECO:0000269|PubMed:18775698, ECO:0000269|PubMed:19234441, ECO:0000269|PubMed:19680540, ECO:0000269|PubMed:21076408, ECO:0000269|PubMed:23300482, ECO:0000269|PubMed:23817550, ECO:0000269|PubMed:28002401}.
uniprot
proteins
mass_dalton
58007
uniprot
proteins
mutagenesis
MUTAGEN 304; /note="H->A: Reduced enzyme activity."; /evidence="ECO:0000269|PubMed:17991826"; MUTAGEN 313; /note="R->A: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:17991826"; MUTAGEN 367; /note="I->A: Reduces enzyme activity by about 60%."; /evidence="ECO:0000269|PubMed:19680540"; MUTAGEN 367; /note="I->F: Alters protein structure and causes an increase in whole body metabolism, leading to a lean phenotype in adult males, but not in females."; /evidence="ECO:0000269|PubMed:19680540
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by DTX2; leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q9C0B1}.
uniprot
proteins
protein_family
Fto family
uniprot
proteins
pubmed
10501967
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17991826
uniprot
proteins
pubmed
18775698
uniprot
proteins
pubmed
19234441
uniprot
proteins
pubmed
19680540
uniprot
proteins
pubmed
21076408
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23300482
uniprot
proteins
pubmed
23817550
uniprot
proteins
pubmed
24646999
uniprot
proteins
pubmed
24807221
uniprot
proteins
pubmed
28002401
uniprot
proteins
sequence_length
502
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17991826, ECO:0000269|PubMed:19234441, ECO:0000269|PubMed:19680540}. Nucleus speckle {ECO:0000250|UniProtKB:Q9C0B1}. Cytoplasm {ECO:0000250|UniProtKB:Q9C0B1}. Note=Localizes mainly in the nucleus, where it is able to demethylate N(6)-methyladenosine (m6A) and N(6),2'-O-dimethyladenosine cap (m6A(m)) in U6 small nuclear RNA (snRNA), N(1)-methyladenine from tRNAs and internal m6A in mRNAs. In the cytoplasm, mediates demethylation of m6A and m6A(m) in mRNAs and N(1)-methyladenine from tRNAs. {ECO:0000250|UniProtKB:Q9C0B1}.
uniprot
proteins