Q63099
uniprot
Q63099
canonical
activity_regulation
ACTIVITY REGULATION: Inhibited by quinine at micromolar levels (By similarity). Modestly sensitive to millimolar levels of tetraethylammonium (TEA) (PubMed:1550672). Modestly sensitive to millimolar levels of 4-aminopyridine (4-AP). {ECO:0000250|UniProtKB:Q95167, ECO:0000269|PubMed:1550672, ECO:0000305|PubMed:10414301}.
uniprot
proteins
amino_acid_sequence
MAEKAPPGLNRKTSRSTLSLPPEPVDIIRSKTCSRRVKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAFTSILNFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMNEELRREAETMRDGEGEEFDNTCCPEKRKKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSLNTLPELQENDEFGQPSDNRKLAHVEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDATKFTSIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRREALERAKRNGSIVSMNLKDAFARSMELIDVAVEKAGESANIKDSVDDNHLSPSRWKWARKALSETSSNKSYENKYQEVSQKDSHEQLNNTSSSSPQHLSAQKLEMLYNEITKTQTHSHPNPDCQEQPERPSAYEEEIEMEEVVCPQEQLAVAQTEVIVDMKSTSSIDSFTSCATDFTETERSPLPPPSASHLQMKFPTDLPGMDEHQRVRAPPFLTLSRDKGPAAREAALDYAPIDITVNLDAGASHGPLQPDSASDSPKSSLKGSNPLKSRSLKVNFQENRGSAPQTPPSTARPLPVTTADFPLTTPQHMSTILLEESPPPGTETLPGADVSAHCQGPSKGLSPRVPKQKLFPFSSRERRSFTEIDTGEDEDFLDLQRPRPDKQADPSPNCLADKPGEARDPLREEGCVGSSSPQNTDHNCRQDIYQAVGEVKKDSSQEGYKMENHLFAPEIHSNPGDTGYCPTRETSM
uniprot
proteins
function
FUNCTION: Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells (PubMed:1550672). Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization (PubMed:1550672, PubMed:20202934, PubMed:9305895). Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel (PubMed:20202934). Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes (PubMed:9305895). In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells (PubMed:1550672, PubMed:20202934). {ECO:0000250|UniProtKB:A6H8H5, ECO:0000269|PubMed:1550672, ECO:0000269|PubMed:20202934, ECO:0000269|PubMed:9305895}.
uniprot
proteins
mass_dalton
102096
uniprot
proteins
post_translational_modification
PTM: Phosphorylated (PubMed:20202934). Phosphorylation at Ser-608 of the FFAT motif activates interaction with MOSPD2, VAPA and VAPB (By similarity). {ECO:0000250|UniProtKB:Q92953, ECO:0000269|PubMed:20202934}.
uniprot
proteins
protein_family
B (Shab) (TC 1.A.1.2) subfamily
uniprot
proteins
protein_family
Kv2.2/KCNB2 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
10414301
uniprot
proteins
pubmed
10719893
uniprot
proteins
pubmed
1550672
uniprot
proteins
pubmed
20202934
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9305895
uniprot
proteins
sequence_length
907
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10719893, ECO:0000269|PubMed:1550672, ECO:0000269|PubMed:20202934, ECO:0000269|PubMed:9305895}; Multi-pass membrane protein {ECO:0000305}. Perikaryon {ECO:0000269|PubMed:10719893, ECO:0000269|PubMed:20202934}. Cell projection, dendrite {ECO:0000269|PubMed:10719893, ECO:0000269|PubMed:20202934}. Note=Localized uniformly throughout cell bodies and dendrites (PubMed:10719893). Colocalizes with KCNB1 to high-density somatodendritic clusters on cortical pyramidal neurons (PubMed:20202934). {ECO:0000269|PubMed:10719893, ECO:0000269|PubMed:20202934}.
uniprot
proteins
transmembrane_region
TRANSMEM 191..212; /note="Helical; Name=Segment S1"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 233..254; /note="Helical; Name=Segment S2"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 266..284; /note="Helical; Name=Segment S3"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 297..317; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 333..355; /note="Helical; Name=Segment S5"; /evidence="ECO:0000250|UniProtKB:P63142"; TRANSMEM 396..424; /note="Helical; Name=Segment S6"; /evidence="ECO:0000250|UniProtKB:P63142
uniprot
proteins