Appl2
entrez
362860
canonical
uniprot
B4F779
canonical
ensembl
ENSRNOG00000008174
resolver
ensembl
ENSRNOG00055021897
resolver
ensembl
ENSRNOG00060028688
resolver
ensembl
ENSRNOG00065021345
resolver
ensp
ENSRNOP00000010986
resolver
ensp
ENSRNOP00055030720
resolver
ensp
ENSRNOP00060041792
resolver
ensp
ENSRNOP00065029323
resolver
enst
ENSRNOT00000010986
resolver
enst
ENSRNOT00055037677
resolver
enst
ENSRNOT00060050153
resolver
enst
ENSRNOT00065036392
resolver
genesymbol
Appl2
resolver
uniprot_entry
DP13B_RAT
resolver
amino_acid_sequence
MPAVDKLLLEEALQDSPQTRSLLSVFEEDAGTLTDYTNQLLQAMQRVYGAQNEMCLATQQLSRQLLAYEKQNFALGKGDEEVISTLHYFSKVMDELNGLHSELAKQLADTMVLPVIQFREKDLTEVSTLKDLFGLASNEHDLSMAKYSRLPKRKENERVKTDVAKEVAAARRKQHLSSLQYYCALNALQYRKRAAMMEPLIGFAHGQINFFKKGAEMFSKSMDGFLSSVTDMVQSIQVELEAEADKMRVSQQELLSVSESVYTPDIDVATPQINRNLIQKTGYLNLRNKTGLVTTTWERLYFFTQGGNLMCQPRGAVAGGLIQDLDNCSVMAVDCEDRRYCFQISTPSGKPGIILQAESRKEYEEWICAINNISRQIYLTDNPEAVAIKLNQTALQAVTPITSFGKKQESFYFSQNIKNSDTGYVKIVPKAAASIPETEELIAPGTPIQFDIVLPATEFLDQNRGSRRINPFGETEDDSFPDAEDSLLQQMFIVRFLGSMAVKTDSTTEVIYEAMRQVLAARAIHNIFRTTESHLMVTSQTLRLIDPQTQVSRACFELTSVTQFAAHQENKRLVGFVIRVPESTGEESLSTYIFESNSEGEKICYAINLGKEIIEVQKDPEALARLMLSVPLTNDGKYVLLNDQADDTGGSPSDHRGAESEA
uniprot
proteins
function
FUNCTION: Multifunctional adapter protein that binds to various membrane receptors, nuclear factors and signaling proteins to regulate many processes, such as cell proliferation, immune response, endosomal trafficking and cell metabolism. Regulates signaling pathway leading to cell proliferation through interaction with RAB5A and subunits of the NuRD/MeCP1 complex (By similarity). Plays a role in immune response by modulating phagocytosis, inflammatory and innate immune responses. In macrophages, enhances Fc-gamma receptor-mediated phagocytosis through interaction with RAB31 leading to activation of PI3K/Akt signaling. In response to LPS, modulates inflammatory responses by playing a key role on the regulation of TLR4 signaling and in the nuclear translocation of RELA/NF-kappa-B p65 and the secretion of pro- and anti-inflammatory cytokines. Also functions as a negative regulator of innate immune response via inhibition of AKT1 signaling pathway by forming a complex with APPL1 and PIK3R1 (By similarity). Plays a role in endosomal trafficking of TGFBR1 from the endosomes to the nucleus (By similarity). Plays a role in cell metabolism by regulating adiponecting and insulin signaling pathways and adaptative thermogenesis (By similarity). In muscle, negatively regulates adiponectin-simulated glucose uptake and fatty acid oyidation by inhibiting adiponectin signaling pathway through APPL1 sequestration thereby antagonizing APPL1 action (By similarity). In muscles, negatively regulates insulin-induced plasma membrane recruitment of GLUT4 and glucose uptake through interaction with TBC1D1 (By similarity). Plays a role in cold and diet-induced adaptive thermogenesis by activating ventromedial hypothalamus (VMH) neurons throught AMPK inhibition which enhances sympathetic outflow to subcutaneous white adipose tissue (sWAT), sWAT beiging and cold tolerance (By similarity). Also plays a role in other signaling pathways namely Wnt/beta-catenin, HGF and glucocorticoid receptor signaling (By similarity). Positive regulator of beta-catenin/TCF-dependent transcription through direct interaction with RUVBL2/reptin resulting in the relief of RUVBL2-mediated repression of beta-catenin/TCF target genes by modulating the interactions within the beta-catenin-reptin-HDAC complex (By similarity). May affect adult neurogenesis in hippocampus and olfactory system via regulating the sensitivity of glucocorticoid receptor. Required for fibroblast migration through HGF cell signaling (By similarity). {ECO:0000250|UniProtKB:Q8K3G9, ECO:0000250|UniProtKB:Q8NEU8}.
uniprot
proteins
mass_dalton
74117
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
30189216
uniprot
proteins
sequence_length
662
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000250|UniProtKB:Q8NEU8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8NEU8}. Nucleus {ECO:0000250|UniProtKB:Q8NEU8}. Cell membrane {ECO:0000250|UniProtKB:Q8NEU8}. Endosome membrane {ECO:0000250|UniProtKB:Q8NEU8}. Cytoplasm {ECO:0000250|UniProtKB:Q8K3G9}. Cytoplasmic vesicle, phagosome {ECO:0000250|UniProtKB:Q8K3G9}. Cell projection, ruffle {ECO:0000250|UniProtKB:Q8K3G9}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:Q8K3G9}. Cell membrane {ECO:0000250|UniProtKB:Q8K3G9}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:Q8K3G9}. Note=Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF. Associates dynamically with cytoplasmic membrane structures that undergo changes in shape, movement, fusion and fission events. PI(4,5)P2 levels are important for membrane association of APPL2 (By similarity). Absent of endosome in macrophage. Colocalized with RAB31 at early-stage phagosome. Localized on macropinosomes in LPS-activated macrophages. Associated with membrane domains in contact with pathogens and pathogen-derived ligands like LPS. First recruited to the ruffles, and accumulates on macropinosomes (By similarity). {ECO:0000250|UniProtKB:Q8K3G9, ECO:0000250|UniProtKB:Q8NEU8}.
uniprot
proteins