SERPINF1
entrez
5176
canonical
uniprot
P36955
canonical
ensembl
ENSG00000132386
resolver
ensp
ENSP00000254722
resolver
ensp
ENSP00000539485
resolver
ensp
ENSP00000539486
resolver
ensp
ENSP00000539487
resolver
ensp
ENSP00000539488
resolver
ensp
ENSP00000539489
resolver
ensp
ENSP00000539491
resolver
ensp
ENSP00000539492
resolver
ensp
ENSP00000539493
resolver
ensp
ENSP00000539494
resolver
ensp
ENSP00000598441
resolver
ensp
ENSP00000630945
resolver
ensp
ENSP00000630947
resolver
enst
ENST00000254722
resolver
enst
ENST00000869426
resolver
enst
ENST00000869427
resolver
enst
ENST00000869428
resolver
enst
ENST00000869429
resolver
enst
ENST00000869430
resolver
enst
ENST00000869432
resolver
enst
ENST00000869433
resolver
enst
ENST00000869434
resolver
enst
ENST00000869435
resolver
enst
ENST00000928382
resolver
enst
ENST00000960886
resolver
enst
ENST00000960888
resolver
genesymbol
SERPINF1
resolver
genesymbol_syn
PEDF
resolver
hgnc
HGNC:8824
resolver
uniprot
A0A140VKF3
resolver
uniprot
F1T092
resolver
uniprot
Q13236
resolver
uniprot
Q2TU83
resolver
uniprot
Q96CT1
resolver
uniprot
Q96R01
resolver
uniprot
Q9BWA4
resolver
uniprot_entry
A0A140VKF3_HUMAN
resolver
uniprot_entry
PEDF_HUMAN
resolver
uniprot_sec
F1T092
resolver
uniprot_sec
Q13236
resolver
uniprot_sec
Q2TU83
resolver
uniprot_sec
Q96CT1
resolver
uniprot_sec
Q96R01
resolver
uniprot_sec
Q9BWA4
resolver
amino_acid_sequence
MQALVLLLCIGALLGHSSCQNPASPPEEGSPDPDSTGALVEEEDPFFKVPVNKLAAAVSNFGYDLYRVRSSTSPTTNVLLSPLSVATALSALSLGAEQRTESIIHRALYYDLISSPDIHGTYKELLDTVTAPQKNLKSASRIVFEKKLRIKSSFVAPLEKSYGTRPRVLTGNPRLDLQEINNWVQAQMKGKLARSTKEIPDEISILLLGVAHFKGQWVTKFDSRKTSLEDFYLDEERTVRVPMMSDPKAVLRYGLDSDLSCKIAQLPLTGSMSIIFFLPLKVTQNLTLIEESLTSEFIHDIDRELKTVQAVLTVPKLKLSYEGEVTKSLQEMKLQSLFDSPDFSKITGKPIKLTQVEHRAGFEWNEDGAGTTPSPGLQPAHLTFPLDYHLNQPFIFVLRDTDTGALLFIGKILDPRGP
uniprot
proteins
disease_involvement
DISEASE: Osteogenesis imperfecta 6 (OI6) [MIM:613982]: A form of osteogenesis imperfecta, a disorder of bone formation characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI6 is a severe, autosomal recessive form compatible with OI type III in the Sillence classification. {ECO:0000269|PubMed:21353196}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. {ECO:0000269|PubMed:7592790, ECO:0000269|PubMed:8226833}.
uniprot
proteins
mass_dalton
46312
uniprot
proteins
post_translational_modification
PTM: The N-terminus is blocked. Extracellular phosphorylation enhances antiangiogenic activity. {ECO:0000269|PubMed:15374885}.; PTM: N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan. {ECO:0000269|PubMed:11562499, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:19838169}.
uniprot
proteins
protein_family
Serpin family
uniprot
proteins
pubmed
10398730
uniprot
proteins
pubmed
11562499
uniprot
proteins
pubmed
12737624
uniprot
proteins
pubmed
15374885
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17032652
uniprot
proteins
pubmed
17081065
uniprot
proteins
pubmed
19139490
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19838169
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21353196
uniprot
proteins
pubmed
21697133
uniprot
proteins
pubmed
22028381
uniprot
proteins
pubmed
22905912
uniprot
proteins
pubmed
7592790
uniprot
proteins
pubmed
8226833
uniprot
proteins
pubmed
8434014
uniprot
proteins
pubmed
8473338
uniprot
proteins
pubmed
9238088
uniprot
proteins
sequence_length
418
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Enriched in stage I melanosomes.
uniprot
proteins