P52189
uniprot
P52189
canonical
amino_acid_sequence
MHGHNRNGQAHVPRRKRRNRFVKKNGQCNVYFANLSNKSQRYMADIFTTCVDTRWRYMLMIFSAAFLVSWLFFGLLFWWIAFFHGDLEASPSVPAVGGPGGNGGESPNAPKPCIMHVNGFLGAFLFSVETQTTIGYGFRCVTEECPLAVIAVVVQSIVGCVIDSFMIGTIMAKMARPKKRAQTLLFSHHAVISVRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPYMTQEGEYLPLDQRDLNVGYDIGLDRIFLVSPIIIVHEIDEDSPLYGMGKEELESEDFEIVVILEGMVEATAMTTQARSSYLASEILWGHRFEPVVFEEKSHYKVDYSRFHKTYEVAGTPCCSARELQESKITVLPAPPPPPSAFCYENELALMSQEEEEMEEEAAAAAAVAAGLGLEAGSKEEAGIIRMLEFGSHLDLERMQAATLPLDNISYRRESRI
uniprot
proteins
function
FUNCTION: Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. {ECO:0000269|PubMed:7926018, ECO:0000269|PubMed:8013643}.
uniprot
proteins
mass_dalton
49899
uniprot
proteins
mutagenesis
MUTAGEN 442..444; /note="ESR->AAA: Abolishes interaction with TAX1BP3."; /evidence="ECO:0000269|PubMed:16855024"; MUTAGEN 442; /note="E->A: Abolishes interaction with TAX1BP3."; /evidence="ECO:0000269|PubMed:16855024"; MUTAGEN 443; /note="S->A,D: Abolishes interaction with TAX1BP3."; /evidence="ECO:0000269|PubMed:16855024"; MUTAGEN 445; /note="I->A: Abolishes interaction with TAX1BP3."; /evidence="ECO:0000269|PubMed:16855024
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ4 subfamily
uniprot
proteins
pubmed
11997254
uniprot
proteins
pubmed
16855024
uniprot
proteins
pubmed
7926018
uniprot
proteins
pubmed
8013643
uniprot
proteins
sequence_length
445
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11997254, ECO:0000269|PubMed:16855024}; Multi-pass membrane protein {ECO:0000255}. Postsynaptic cell membrane {ECO:0000269|PubMed:11997254}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000269|PubMed:16855024}. Note=TAX1BP3 binding promotes dissociation of KCNJ4 from LIN7 family members and KCNJ4 internalization. {ECO:0000269|PubMed:16855024}.
uniprot
proteins
transmembrane_region
TRANSMEM 56..80; /note="Helical; Name=M1"; /evidence="ECO:0000250"; TRANSMEM 148..169; /note="Helical; Name=M2"; /evidence="ECO:0000250
uniprot
proteins