Creb3l2
entrez
362339
canonical
uniprot
Q6QDP7
canonical
ensembl
ENSRNOG00000012826
resolver
ensembl
ENSRNOG00000026705
resolver
ensembl
ENSRNOG00065016633
resolver
ensp
ENSRNOP00000017338
resolver
ensp
ENSRNOP00000103942
resolver
ensp
ENSRNOP00065021832
resolver
enst
ENSRNOT00000017338
resolver
enst
ENSRNOT00065027712
resolver
genesymbol
Creb3l2
resolver
genesymbol_syn
Ra69
resolver
uniprot
A0A8L2Q9L4
resolver
uniprot_entry
A0A8L2Q9L4_RAT
resolver
uniprot_entry
CR3L2_RAT
resolver
amino_acid_sequence
MEVLESGEQSVLQWDRKLSELSEPGETEALMYHTHFSELLDEFSQNVLGQLLNDPFLSEKSVSMEVEPSPTSPAPLIQAEHSYSLSEEPRAQSPFTHVAASDGFNDEEVESEKWYLSTEFPSATIKTEPITEEQPPGLVPSVTLTITAISTPFEKEESPLDMSAGGDSSCQTLIPKIKLEPHEVDQFLNFSPKEASVDQLHLPPTPPSSHSSDSEGSLSPNPRLHPFSLSQAHSPGRAMPRGPSALSTSPLLTAPHKLQGSGPLVLTEEEKRTLIAEGYPIPTKLPLTKSEEKALKKIRRKIKNKISAQESRRKKKEYMDSLEKKVESCSTENLELRKKVEVLENTNRTLLQQLQKLQTLVMGKVSRTCKLAGTQTGTCLMVVVLCFAVAFGSLFQGYGLYPSATKMALPSQHPLSEPYTASVVRSRNLLIYEEHSSLEESSSPASAGELGGWDRGSSLLRASSGLEALPEVDLPHFIISKETSLEKSVLLELQQHLVSSKLEGNETLKVVELERRVNATF
uniprot
proteins
function
FUNCTION: Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes. In a neuroblastoma cell line, protects cells from ER stress-induced death. In vitro activates transcription of target genes via direct binding to the CRE site. {ECO:0000250|UniProtKB:Q8BH52}.
uniprot
proteins
mass_dalton
57379
uniprot
proteins
post_translational_modification
PTM: Upon ER stress, translocated to the Golgi apparatus, where it is processed by regulated intramembrane proteolysis (RIP) to release the cytosol-facing N-terminal transcription factor domain. The cleavage is performed sequentially by site-1 and site-2 proteases (S1P/MBTPS1 and S2P/MBTPS2). {ECO:0000250|UniProtKB:Q8BH52}.; PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q8BH52}.; PTM: Ubiquitinated by HRD1/SYVN1; undergoes 'Lys-48'-linked ubiquitination, followed by rapid proteasomal degradation under normal conditions. Upon ER stress, SYVN1 E3 ubiquitin-protein ligase dissociates from its substrate, ubiquitination does not occur and CREB3L2 is stabilized. {ECO:0000250|UniProtKB:Q8BH52}.
uniprot
proteins
protein_family
ATF subfamily
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
sequence_length
521
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8BH52}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q8BH52}. Note=ER membrane resident protein. Upon ER stress, translocated to the Golgi apparatus where it is cleaved. The cytosolic N-terminal fragment (processed cyclic AMP-responsive element-binding protein 3-like protein 1) is transported into the nucleus. {ECO:0000250|UniProtKB:Q8BH52}.; SUBCELLULAR LOCATION: [Processed cyclic AMP-responsive element-binding protein 3-like protein 2]: Nucleus {ECO:0000250|UniProtKB:Q8BH52}. Note=Upon ER stress, translocated into the nucleus. {ECO:0000250|UniProtKB:Q8BH52}.
uniprot
proteins
transmembrane_region
TRANSMEM 379..399; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins