Pou1f1
entrez
18736
canonical
uniprot
Q00286
canonical
ensembl
ENSMUSG00000004842
resolver
ensp
ENSMUSP00000135113
resolver
ensp
ENSMUSP00000139087
resolver
genesymbol
Pou1f1
resolver
genesymbol_syn
Pit-1
resolver
genesymbol_syn
Pit1
resolver
uniprot_entry
PIT1_MOUSE
resolver
amino_acid_sequence
MSCQSFTSADTFITLNSDASAALPLRMHHSAAECLPASNHATNVMSTATGLHYSVPSCHYGNQPSTYGVMAGSLTPCLYKFPDHTLSHGFPPLHQPLLAEDPAASEFKQELRRKSKLVEEPIDMDSPEIRELEQFANEFKVRRIKLGYTQTNVGEALAAVHGSEFSQTTICRFENLQLSFKNACKLKAILSKWLEEAEQVGALYNEKVGANERKRKRRTTISVAAKDALERHFGEHSKPSSQEIMRMAEELNLEKEVVRVWFCNRRQREKRVKTSLNQSLFSISKEHLECR
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Pou1f1 are the cause of the dwarf (dw) phenotype which interrupts the normal development of the anterior pituitary gland, resulting in the loss of expression of growth hormone, prolactin and thyroid-stimulating hormone, and hypoplasia of their respective cell types. {ECO:0000269|PubMed:1977085}.
uniprot
proteins
function
FUNCTION: Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT-3'. {ECO:0000250|UniProtKB:P28069}.
uniprot
proteins
mass_dalton
32885
uniprot
proteins
protein_family
Class-1 subfamily
uniprot
proteins
protein_family
POU transcription factor family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1561093
uniprot
proteins
pubmed
1977085
uniprot
proteins
pubmed
8407911
uniprot
proteins
sequence_length
291
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P28069}.
uniprot
proteins