PCGF5
entrez
84333
canonical
uniprot
Q86SE9
canonical
ensembl
ENSG00000180628
resolver
ensp
ENSP00000337500
resolver
ensp
ENSP00000445704
resolver
ensp
ENSP00000479492
resolver
ensp
ENSP00000558265
resolver
ensp
ENSP00000558267
resolver
ensp
ENSP00000558273
resolver
ensp
ENSP00000558278
resolver
ensp
ENSP00000558279
resolver
ensp
ENSP00000558280
resolver
genesymbol
PCGF5
resolver
genesymbol_syn
RNF159
resolver
hgnc
HGNC:28264
resolver
uniprot
B7Z892
resolver
uniprot
D3DR33
resolver
uniprot
Q6PK47
resolver
uniprot
Q86TD0
resolver
uniprot_entry
PCGF5_HUMAN
resolver
uniprot_sec
B7Z892
resolver
uniprot_sec
D3DR33
resolver
uniprot_sec
Q6PK47
resolver
uniprot_sec
Q86TD0
resolver
amino_acid_sequence
MATQRKHLVKDFNPYITCYICKGYLIKPTTVTECLHTFCKTCIVQHFEDSNDCPRCGNQVHETNPLEMLRLDNTLEEIIFKLVPGLREQELERESEFWKKNKPQENGQDDTSKADKPKVDEEGDENEDDKDYHRSDPQIAICLDCLRNNGQSGDNVVKGLMKKFIRCSTRVTVGTIKKFLSLKLKLPSSYELDVLCNGEIMGKDHTMEFIYMTRWRLRGENFRCLNCSASQVCSQDGPLYQSYPMVLQYRPRIDFG
uniprot
proteins
function
FUNCTION: Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Plays a redundant role with PCGF3 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity). {ECO:0000250|UniProtKB:Q3UK78, ECO:0000269|PubMed:26151332}.
uniprot
proteins
mass_dalton
29714
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21282530
uniprot
proteins
pubmed
25519132
uniprot
proteins
pubmed
26151332
uniprot
proteins
sequence_length
256
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21282530, ECO:0000269|PubMed:25519132}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q3UK78}. Note=Recruited by the non-coding RNA Xist to specific nuclear foci that probably correspond to the inactivated X chromosome. {ECO:0000250|UniProtKB:Q3UK78}.
uniprot
proteins