Fbxo7
entrez
366854
canonical
uniprot
Q68FS3
canonical
ensembl
ENSRNOG00000004637
resolver
ensembl
ENSRNOG00055021987
resolver
ensembl
ENSRNOG00060026611
resolver
ensembl
ENSRNOG00065024950
resolver
ensp
ENSRNOP00000006366
resolver
ensp
ENSRNOP00055030785
resolver
ensp
ENSRNOP00060038325
resolver
ensp
ENSRNOP00065035099
resolver
enst
ENSRNOT00000006366
resolver
enst
ENSRNOT00055037742
resolver
enst
ENSRNOT00060046136
resolver
enst
ENSRNOT00065042890
resolver
genesymbol
Fbxo7
resolver
uniprot_entry
FBX7_RAT
resolver
amino_acid_sequence
MKLRVRLQKRTQPLEVPESEPTLGQLRAHLIQDLLPTLGFSSDTRFAITLNNKDALTGDEETLASYGIVSGDLICLVLEDEMPAPNLPSSTDSEHSSLQNNDQPPLAATSSQANIPDEQGSDSSHGQVTQYDAWTDDSMEGPSHSAEAVSIQDAMSVEEASGFHPLEPMLCSETEDGQVPHSLEALYQSAGCSTVSDALIVLVHLLMLESGYIPQGTEAKAASMPEKWKSSGVYKLQYTHPLCEGGSAVLTCVPLGKLIMINATIKVNGGIKNVKSVQLKPGAYVRRAEPGESAAKVYKDLKKLSRLFKDQLVYPLLAFTRQVLNLPDVFGLVVLPLELKLRIFRLLDVHSVLALSAVCHDLLIASNDPLLWRCLYLRDFRDSTIRGPDTDWKELYRKKHIQRKEAQRMRHVMYLPSVHPIPFCPIPVYPRPYLPTTLLPPGIIGGEYDERPILPSVGDPVTSLIPRPGEPPSQFRPVRPRFDPVGPLPGSNSLLPGRASPNNRFPFRPGRGRSADNRLPYL
uniprot
proteins
function
FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins and plays a role in several biological processes such as cell cycle, cell proliferation, or maintenance of chromosome stability. Recognizes and ubiquitinates BIRC2 and the cell cycle regulator DLGAP5. Plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. Promotes MFN1 ubiquitination. Mediates the ubiquitination and proteasomal degradation of UXT isoform 2, thereby impairing the NF-kappa-B signaling pathway. Inhibits NF-kappa-B pathway also by promoting the ubiquitination of TRAF2 (By similarity). Affects the assembly state and activity of the proteasome in the cells including neurons by ubiquitinating the proteasomal subunit PSMA2 via 'Lys-63'-linked polyubiquitin chains (By similarity). Promotes 'Lys-48'-linked polyubiquitination SIRT7, leading to the hydrogen peroxide-induced cell death (By similarity). {ECO:0000250|UniProtKB:Q3U7U3, ECO:0000250|UniProtKB:Q9Y3I1}.
uniprot
proteins
mass_dalton
57561
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
522
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Mitochondrion {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Note=Predominantly cytoplasmic. A minor proportion is detected in the nucleus. Relocates from the cytosol to depolarized mitochondria (By similarity). {ECO:0000250}.
uniprot
proteins