Slc9b2
entrez
97086
canonical
uniprot
Q5BKR2
canonical
ensembl
ENSMUSG00000037994
resolver
ensp
ENSMUSP00000060640
resolver
ensp
ENSMUSP00000194959
resolver
ensp
ENSMUSP00000194960
resolver
ensp
ENSMUSP00000357155
resolver
genesymbol
Slc9b2
resolver
genesymbol_syn
Nha2
resolver
genesymbol_syn
Nhe10
resolver
genesymbol_syn
Nhedc2
resolver
uniprot
Q8CA47
resolver
uniprot
Q8CDX4
resolver
uniprot_entry
SL9B2_MOUSE
resolver
uniprot_sec
Q8CA47
resolver
uniprot_sec
Q8CDX4
resolver
activity_regulation
ACTIVITY REGULATION: Allosterically inhibited by the N-terminal domain. Inhibited by phloretin. {ECO:0000250|UniProtKB:Q86UD5}.
uniprot
proteins
amino_acid_sequence
MEDEDKTAECQHSKPPTGITHEAPPHHELQEERVMSLRGTDRSEPTEGSNLLTSGEKKPQDSPTEPNGLQSLRRFLACPPRGCLARVITNGTMVVLLWAMVWSVTGPECLPGGNLFGIIILFYCSITGGKLFGLIKFPTLPPLPPLLGMLLAGFLLRNIPVINDSVRIQHKWSSSLRSIALSVILVRAGLGLDSKALRKLKGVCVRLAMGPCIVEACASAILSHFLMGLPWQWGFILGFVVGAVSPAVVVPSMLLLQEGGYGVGKGIPTLLMAAGSFDDILAITGFNTCLGVAFSTGSTVFNIFRGILEVVIGVAAGSFLGFFIQYFPSRDQDNLVWKRAFLVLGFAVLAVFSSVYFSFPGSGGLCTLVMAFLAGMRWTDKKSEVEKVIAVTWDVFQPLLFGLIGAEVSIVSLRAETVGLCVATLSIAVLIRILTTFLMVCFAGFNIKEKIFISFAWLPKATVQAAIGSVALDTARSHGEKQLEDYGMDVLTVAFLAILITAPIGSLLIGLLGPRVLQKSEHRTEEEVQGETSAHIQRKPEDSITEA
uniprot
proteins
function
FUNCTION: Electroneutral Na(+) Li(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane (PubMed:17988971, PubMed:18508966). Uses the proton gradient/membrane potential to extrude sodium (By similarity). Contributes to the regulation of intracellular pH and sodium homeostasis (PubMed:27909897). Also able to mediate Na(+)/Li(+) antiporter activity in kidney (By similarity). May play a physiological role in renal tubular function and blood pressure homeostasis (PubMed:27909897, PubMed:32956652). Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells (PubMed:23720317). Involved in sperm motility and fertility (PubMed:27010853). It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not (PubMed:17988971, PubMed:20441802). {ECO:0000250|UniProtKB:Q86UD5, ECO:0000269|PubMed:17988971, ECO:0000269|PubMed:18508966, ECO:0000269|PubMed:20441802, ECO:0000269|PubMed:23720317, ECO:0000269|PubMed:27010853, ECO:0000269|PubMed:27909897, ECO:0000269|PubMed:32956652}.
uniprot
proteins
mass_dalton
58934
uniprot
proteins
protein_family
Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17698421
uniprot
proteins
pubmed
17988971
uniprot
proteins
pubmed
18000046
uniprot
proteins
pubmed
18269914
uniprot
proteins
pubmed
18508966
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20441802
uniprot
proteins
pubmed
22985540
uniprot
proteins
pubmed
23720317
uniprot
proteins
pubmed
27010853
uniprot
proteins
pubmed
27909897
uniprot
proteins
pubmed
32956652
uniprot
proteins
sequence_length
547
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:18508966, ECO:0000269|PubMed:20441802}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A6P3HVI0}. Mitochondrion membrane {ECO:0000269|PubMed:17988971}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A6P3HVI0}. Endosome membrane {ECO:0000269|PubMed:23720317}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A6P3HVI0}. Lysosome membrane {ECO:0000269|PubMed:20441802}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A6P3HVI0}. Recycling endosome membrane {ECO:0000269|PubMed:32956652}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A6P3HVI0}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:23720317}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A6P3HVI0}. Cell projection, cilium, flagellum membrane {ECO:0000269|PubMed:27010853}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A6P3HVI0}. Basolateral cell membrane {ECO:0000269|PubMed:20441802}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A6P3HVI0}. Apical cell membrane {ECO:0000269|PubMed:27909897}; Multi-pass membrane protein {ECO:0000250|UniProtKB:A0A6P3HVI0}. Note=Strong colocalization with LAMP1 and TCIRG1 in osteoclasts (PubMed:20441802). In beta-cells colocalizes with RAB4A and SYP (PubMed:23720317). Localizes to the basolateral membrane of polarized osteoclasts (PubMed:20441802). Localizes to the apical membrane of distal convoluted and connecting tubules (PubMed:27909897). {ECO:0000269|PubMed:17988971, ECO:0000269|PubMed:20441802, ECO:0000269|PubMed:23720317}.
uniprot
proteins
transmembrane_region
TRANSMEM 87..104; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:A0A6P3HVI0, ECO:0000255"; TRANSMEM 114..133; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:A0A6P3HVI0, ECO:0000255"; TRANSMEM 145..161; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:A0A6P3HVI0, ECO:0000255"; TRANSMEM 172..189; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:A0A6P3HVI0, ECO:0000255"; TRANSMEM 201..227; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:A0A6P3HVI0"; TRANSMEM 234..242; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:A0A6P3HVI0"; TRANSMEM 271..290; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:A0A6P3HVI0"; TRANSMEM 301..324; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:A0A6P3HVI0"; TRANSMEM 340..357; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:A0A6P3HVI0"; TRANSMEM 362..373; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:A0A6P3HVI0"; TRANSMEM 391..411; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:A0A6P3HVI0"; TRANSMEM 418..440; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:A0A6P3HVI0"; TRANSMEM 462..473; /note="Helical; Name=13"; /evidence="ECO:0000250|UniProtKB:A0A6P3HVI0"; TRANSMEM 487..509; /note="Helical; Name=14"; /evidence="ECO:0000250|UniProtKB:A0A6P3HVI0
uniprot
proteins