C0HM98
uniprot
C0HM98
canonical
amino_acid_sequence
MWLVECTGRDLTGLSCLLSMDRQPRRRQHVAGCRDVPPPLPQGSWGQTSPRHSILCSKSGCDLLGGGEYNGETSGEEFLAPAWTCRAQQAATWLSVQQTSHKALGPAGGAAMSSKLSPEEQFLSRIHFLRTFMCSVAGAELPGIPQATENGEGCRPARDPASSPSSLSMASVYTQCSSAQLVSALS
uniprot
proteins
function
FUNCTION: Promotes DNA damage repair through both homologous recombination repair (HRR) and post-replication repair (PRR) mechanisms (PubMed:35849344). Enhances the retention of DNA damage response protein RAD18 at sites of DNA damage (PubMed:35849344). This allows for HRR via association of RAD18 with RAD51C and for PRR via RAD18-mediated promotion of PCNA monoubiquitination (PubMed:35849344). {ECO:0000269|PubMed:35849344}.
uniprot
proteins
mass_dalton
19739
uniprot
proteins
mutagenesis
MUTAGEN 174; /note="T->A: Abolishes DNA damage repair function as well as DDUP foci formation and enrichment of DDUP in chromatin upon DNA damage. Abolishes interaction with H2AX and RAD18."; /evidence="ECO:0000269|PubMed:35849344"; MUTAGEN 174; /note="T->D: Does not affect interaction with H2AX or RAD18."; /evidence="ECO:0000269|PubMed:35849344
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in an ATR-dependent manner; phosphorylation is required for interaction with H2AX and RAD18 and for DDUP-mediated DNA damage repair. {ECO:0000269|PubMed:35849344}.
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
35849344
uniprot
proteins
sequence_length
186
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:35849344}. Chromosome {ECO:0000269|PubMed:35849344}. Note=Forms DNA damage-induced foci. {ECO:0000269|PubMed:35849344}.
uniprot
proteins