Atic
entrez
108147
canonical
uniprot
Q9CWJ9
canonical
ensembl
ENSMUSG00000026192
resolver
ensp
ENSMUSP00000027384
resolver
enst
ENSMUST00000027384
resolver
genesymbol
Atic
resolver
genesymbol_syn
Purh
resolver
uniprot
Q3UTQ3
resolver
uniprot
Q80UH0
resolver
uniprot
Q8BPF0
resolver
uniprot
Q8BQV9
resolver
uniprot
Q9CRI1
resolver
uniprot
Q9CZW9
resolver
uniprot_entry
PUR9_MOUSE
resolver
uniprot_sec
Q3UTQ3
resolver
uniprot_sec
Q80UH0
resolver
uniprot_sec
Q8BPF0
resolver
uniprot_sec
Q8BQV9
resolver
uniprot_sec
Q9CRI1
resolver
uniprot_sec
Q9CZW9
resolver
activity_regulation
ACTIVITY REGULATION: AMP and XMP inhibit AICAR formyltransferase activity (By similarity). AICAR formyltransferase activity is inhibited by N-(6-fluoro-1-oxo-1,2-dihydroisoquinolin-7-yl)-5- [(3R)-3-hydroxypyrrolidin-1-yl]thiophene-2-sulfonamide (LSN 3213128), which acts as a tumor suppression in cancer cell lines (PubMed:29072452). {ECO:0000250|UniProtKB:P31939, ECO:0000269|PubMed:29072452}.
uniprot
proteins
amino_acid_sequence
MAPSQLALFSVSDKTGLVEFARSLASLGLSLVASGGTAKAIRDAGLAVRDVSELTGFPEMLGGRVKTLHPAVHAGILARNIPEDAADMARLDFNLVRVVVCNLYPFVKTVASPDVTVEAAVEQIDIGGVTLLRAAAKNHARVTVVCEPEDYAGVAAEMHGSDSKDTSLETRRHLALKAFTHTAQYDEAISDYFRKQYSKGISQMPLRYGMNPHQTPAQLYTLKPKLPITVLNGAPGFINLCDALNAWQLVTELRGAVDIPAAASFKHVSPAGAAVGVPLSEDEARVCMVYDLYPTLTPLAVAYARARGADRMSSFGDFVALSDICDVPTAKIISREVSDGIVAPGYEEEALKILSKKKNGNYCVLQMDQSYKPDENEVRTLFGLRLSQKRNNGVVDKSLFSNIVTKNKDLPESALRDLIVATVAVKYTQSNSVCYAKDGQVIGIGAGQQSRIHCTRLAGDKANSWWLRHHPRVLSMKFKAGVKRAEISNAIDQYVTGTIGEGEDLVKWEALFEEVPELLTEAEKKEWVDKLSGVSVSSDAFFPFRDNVDRAKRSGVAYIVAPSGSTADKVVIEACDELGIVLAHTDLRLFHH
uniprot
proteins
ec_number
2.1.2.3
uniprot
proteins
ec_number
3.5.4.10
uniprot
proteins
function
FUNCTION: Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:29072452). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:29072452). Also displays cyclohydrolase activity involving the cyclization of FAICAR to inosine monophosphate (IMP). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction. Also catalyzes the cyclization of FAICAR to IMP. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (By similarity). {ECO:0000250|UniProtKB:P31939, ECO:0000269|PubMed:29072452}.
uniprot
proteins
mass_dalton
64217
uniprot
proteins
pathway_participation
PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. {ECO:0000269|PubMed:29072452}.; PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1. {ECO:0000250|UniProtKB:P31939}.
uniprot
proteins
protein_family
PurH family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29072452
uniprot
proteins
sequence_length
592
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P54113}.
uniprot
proteins