Tespa1
entrez
67596
canonical
uniprot
Q3U132
canonical
ensembl
ENSMUSG00000034833
resolver
ensp
ENSMUSP00000047284
resolver
ensp
ENSMUSP00000284892
resolver
genesymbol
Tespa1
resolver
uniprot
Q3TR68
resolver
uniprot
Q8CEN9
resolver
uniprot_entry
TESP1_MOUSE
resolver
uniprot_sec
Q3TR68
resolver
uniprot_sec
Q8CEN9
resolver
amino_acid_sequence
MEASVLSPTSWEKRRAWLRQSRNWQTQVLEEEAAAALQDALDPEPSSLDDVFQEGNPINKIEDWLQGCGCRDTEEGLSEESGQSNYSGYSSHGTSFEDDLSLGAEATLLSTNGNLFSRNFLQTPRLCQLLDLGSSLASSSMTGGTNKTSSSISEILDQVQEDAEDILFSLGFGHENHKDTSRIPARFFSNPSQAKGINFQLFLKSQVQRMEMEDPCLMLASRFKQVQTLAVTADAFFCLYSYVSKTPVQKFTPSNMFWNFDPTDVPSIRILAPEPEPYSPRERLRRAISKMCLYTGSRDRLSSSYNNPKKNSLDQIVWEVMDRVKGEKIQQDPEHRQALGEESVPPIQNTNPSTSSLPCVSYPKEETQGDMCHAHALARPGPQYHINSTQVRRQLWVLQDINEKPRSAENESPWERKSKARKNLFQRVPVDKNIKSLNLPTIQQKQNQGQARHELTNL
uniprot
proteins
function
FUNCTION: May play a role in the regulation of inositol 1,4,5-trisphosphate receptor-mediated Ca(2+) release and mitochondrial Ca(2+) uptake via the mitochondria-associated endoplasmic reticulum membrane (MAM) compartment (By similarity). Required for the development and maturation of T-cells, its function being essential for the late stages of thymocyte development. Plays a role in T-cell antigen receptor (TCR)-mediated activation of the ERK and NFAT signaling pathways, possibly by serving as a scaffolding protein that promotes the assembly of the LAT signalosome in thymocytes. {ECO:0000250, ECO:0000269|PubMed:22561606}.
uniprot
proteins
mass_dalton
51768
uniprot
proteins
post_translational_modification
PTM: May be phosphorylated in response to store-operated Ca(+2) entry. {ECO:0000269|PubMed:23541577}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22561606
uniprot
proteins
pubmed
23541577
uniprot
proteins
pubmed
23650607
uniprot
proteins
sequence_length
458
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:A2RU30}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23650607}. Note=May localize to mitochondria-associated endoplasmic reticulum membrane (MAM). {ECO:0000250|UniProtKB:A2RU30}.
uniprot
proteins