Anp32a
entrez
25379
canonical
uniprot
P49911
canonical
ensembl
ENSRNOG00000014846
resolver
ensp
ENSRNOP00000081689
resolver
enst
ENSRNOT00000103076
resolver
genesymbol
Anp32a
resolver
genesymbol_syn
Lanp
resolver
uniprot
A0A8I5ZVJ3
resolver
uniprot
A0ACM8Q6E7
resolver
uniprot
Q5PPH9
resolver
uniprot_entry
A0ACM8Q6E7_RAT
resolver
uniprot_entry
AN32A_RAT
resolver
uniprot_entry
Q5PPH9_RAT
resolver
uniprot_sec
A0A8I5ZVJ3
resolver
amino_acid_sequence
MEMDKRIYLELRNRTPSDVKELVLDNCRSIEGKIEGLTDEFEELEFLSTINVGLTSISNLPKLNKLKKLELSENRISGDLEVLAEKCPNLKHLNLSGNKIKDLSTIEPLKKLENLKSLDLFNCEVTNLNAYRENVFKLLPQVMYLDGYDRDNKEAPDSDVEGYVEDDDEEDEDEEEYDEYAQLVEDEEEEDEEEEGEEEDVSGEEEEDEEGYNDGEVDDEEDEEDAAEEEGSQKRKREPDDEGQEDD
uniprot
proteins
function
FUNCTION: Multifunctional protein that is involved in the regulation of many processes including tumor suppression, apoptosis, cell cycle progression or transcription. Promotes apoptosis by favouring the activation of caspase-9/CASP9 and allowing apoptosome formation. In addition, plays a role in the modulation of histone acetylation and transcription as part of the INHAT (inhibitor of histone acetyltransferases) complex. Inhibits the histone-acetyltransferase activity of EP300/CREBBP (CREB-binding protein) and EP300/CREBBP-associated factor by histone masking. Preferentially binds to unmodified histone H3 and sterically inhibiting its acetylation and phosphorylation leading to cell growth inhibition. Participates in other biochemical processes such as regulation of mRNA nuclear-to-cytoplasmic translocation and stability by its association with ELAVL1 (Hu-antigen R). Plays a role in E4F1-mediated transcriptional repression as well as inhibition of protein phosphatase 2A. {ECO:0000250|UniProtKB:P39687}.
uniprot
proteins
mass_dalton
28565
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine residues, at least in part by casein kinase 2/CK2. {ECO:0000250|UniProtKB:P39687}.; PTM: Some glutamate residues are glycylated by TTLL8. This modification occurs exclusively on glutamate residues and results in a glycine chain on the gamma-carboxyl group (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
ANP32 family
uniprot
proteins
pubmed
15895553
uniprot
proteins
pubmed
7937870
uniprot
proteins
sequence_length
247
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Note=Translocates to the cytoplasm during the process of neuritogenesis. Shuttles between nucleus and cytoplasm (By similarity). {ECO:0000250}.
uniprot
proteins