Dgki
entrez
688705
canonical
uniprot
F1MAB7
canonical
ensembl
ENSRNOG00000026705
resolver
ensembl
ENSRNOG00055029887
resolver
ensembl
ENSRNOG00060024590
resolver
ensembl
ENSRNOG00065016585
resolver
ensp
ENSRNOP00000034571
resolver
ensp
ENSRNOP00000072665
resolver
ensp
ENSRNOP00000079887
resolver
enst
ENSRNOT00000079285
resolver
enst
ENSRNOT00000120235
resolver
genesymbol
Dgki
resolver
uniprot
A0A0G2K3J7
resolver
uniprot
A0A8I5ZPA8
resolver
uniprot
Q810C3
resolver
uniprot
Q810C4
resolver
uniprot
Q810C5
resolver
uniprot_entry
A0A0G2K3J7_RAT
resolver
uniprot_entry
A0A8I5ZPA8_RAT
resolver
uniprot_entry
DGKI_RAT
resolver
uniprot_sec
Q810C3
resolver
uniprot_sec
Q810C4
resolver
uniprot_sec
Q810C5
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphatidylserine. {ECO:0000269|PubMed:15024004}.
uniprot
proteins
amino_acid_sequence
MDAAGRGCHLLPLPAARGPARAPAASSALSPAGLCSGTASASSAAAGAVAMNPSSSAGEERGATGGSSSSGSGAGSCCLGAEGGVDPRGAGAAAAAALEEPAAAGQKEKEEALEEKLRDLTFRKQVSYRKAISRTGLQHLAPAHPLGLPVANGPAKEPRATLDWSENAVNGEHLWLETNVSGDLCYLGEENCQVRFAKSALRRKCAVCKIVVHTACIEQLEKINFRCKPTFREGGSRSPRENFVRHHWVHRRRQEGKCKQCGKGFQQKFSFHSKEIVAISCSWCKQAFHNKVTCFMLHHIEEPCSLGAHAAVIVPPTWIIKVKKPQNSLKASNRKKKRTSFKRKASKRGTEQENKGRPFVIKPISSPLMKPLLVFVNPKSGGNQGTKVLQMFMWYLNPRQVFDLSQEGPKDALELYRKVPNLRILACGGDGTVGWILSILDELQLSPQPPVGVLPLGTGNDLARTLNWGGGYTDEPVSKILCQVEDGTIVQLDRWNLHVERNPDLPPEELEDGVCKLPLNVFNNYFSLGFDAHVTLEFHESREANPEKFNSRFRNKMFYAGAAFSDFLQRSSRDLSKHVKVVCDGTDLTPKIQDLKFQCIVFLNIPRYCAGTMPWGNPGDHHDFEPQRHDDGYIEVIGFTMASLAALQVGGHGERLHQCREVMLLTYKSIPMQVDGEPCRLAPAMIRISLRNQANMVQKSKRRTSMPLLNDPQSVPDRLRIRVNKISLQDYEGLHYDKEKLREASIPLGILVVRGDCDLETCRMYIDRLQEDLQSVSSGSQRVHYQDQETSFPRAISAQRLSPRWCFLDATSADRFYRIDRSQEHLHFVMEISHDEIFILDPDMVVSQQAGTPPGMPDLVVEQASGLSDWWNPALRKRMLSDSGMITPHYEDSDLKDFSHSRVLQSPVSSEDHAILQAVITGDLMKLMESYKNGGSLLIQGPGHCSLLHYAAKTGNGEIVKYILDHGPAELLDMADSETGETALHKAACQRNRAVCQLLVDAGASLRQTDSKGKTPQERAQQAGDPDLAAYLESRQNYKIIGHEDLETAV
uniprot
proteins
ec_number
2.7.1.107
uniprot
proteins
function
FUNCTION: Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:15024004). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has probably no preference for any of the diacylglycerols in terms of the acyl chain composition, especially for the acyl chain at the sn-2 position (PubMed:15024004). By controlling the diacylglycerol/DAG-mediated activation of RASGRP3, negatively regulates the Rap1 signaling pathway. May play a role in presynaptic diacylglycerol/DAG signaling and control neurotransmitter release during metabotropic glutamate receptor-dependent long-term depression (By similarity). {ECO:0000250|UniProtKB:D3YWQ0, ECO:0000269|PubMed:15024004, ECO:0000305}.; FUNCTION: [Isoform 2]: Has a decreased affinity for ATP and a reduced diacylglycerol kinase activity. Has no preference for any of the diacylglycerols in terms of the acyl chain composition. {ECO:0000269|PubMed:15024004}.; FUNCTION: [Isoform 3]: Has no diacylglycerol kinase activity. {ECO:0000269|PubMed:15024004}.
uniprot
proteins
mass_dalton
115894
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; glycerolipid metabolism. {ECO:0000269|PubMed:15024004}.
uniprot
proteins
protein_family
Eukaryotic diacylglycerol kinase family
uniprot
proteins
pubmed
15024004
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
21119615
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
1050
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, axon {ECO:0000269|PubMed:21119615}. Cell projection, dendrite {ECO:0000269|PubMed:21119615}. Presynapse {ECO:0000269|PubMed:21119615}. Postsynapse {ECO:0000269|PubMed:21119615}. Postsynaptic density {ECO:0000269|PubMed:21119615}. Synaptic cell membrane {ECO:0000269|PubMed:21119615}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000269|PubMed:21119615}. Cytoplasm, cytosol {ECO:0000269|PubMed:15024004, ECO:0000269|PubMed:21119615}. Nucleus {ECO:0000250|UniProtKB:O75912}. Note=Excluded from inhibitory synapses (PubMed:21119615). Localization between cytoplasm and nucleus is regulated by protein kinase C (By similarity). Both in the detergent soluble and particulate fractions (PubMed:15024004). {ECO:0000250|UniProtKB:O75912, ECO:0000269|PubMed:15024004, ECO:0000269|PubMed:21119615}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:15024004}. Note=Not detected in detergent soluble fraction. {ECO:0000269|PubMed:15024004}.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm {ECO:0000269|PubMed:15024004}. Note=Not detected in detergent soluble fraction. {ECO:0000269|PubMed:15024004}.
uniprot
proteins