MCOLN2
entrez
255231
canonical
uniprot
Q8IZK6
canonical
ensembl
ENSG00000153898
resolver
ensp
ENSP00000284027
resolver
ensp
ENSP00000359640
resolver
ensp
ENSP00000784876
resolver
genesymbol
MCOLN2
resolver
hgnc
HGNC:13357
resolver
uniprot
A6NI99
resolver
uniprot
Q2M3I6
resolver
uniprot
Q5TAG5
resolver
uniprot
Q8N9R3
resolver
uniprot_entry
MCLN2_HUMAN
resolver
uniprot_sec
A6NI99
resolver
uniprot_sec
Q2M3I6
resolver
uniprot_sec
Q5TAG5
resolver
uniprot_sec
Q8N9R3
resolver
activity_regulation
ACTIVITY REGULATION: Channel activity is reduced by low extracellular/lumenal pH level (PubMed:19940139). {ECO:0000269|PubMed:19940139, ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MARQPYRFPQARIPERGSGVFRLTVRNAMAHRDSEMKEECLREDLKFYFMSPCEKYRARRQIPWKLGLQILKIVMVTTQLVRFGLSNQLVVAFKEDNTVAFKHLFLKGYSGTDEDDYSCSVYTQEDAYESIFFAINQYHQLKDITLGTLGYGENEDNRIGLKVCKQHYKKGTMFPSNETLNIDNDVELDCVQLDLQDLSKKPPDWKNSSFFRLEFYRLLQVEISFHLKGIDLQTIHSRELPDCYVFQNTIIFDNKAHSGKIKIYFDSDAKIEECKDLNIFGSTQKNAQYVLVFDAFVIVICLASLILCTRSIVLALRLRKRFLNFFLEKYKRPVCDTDQWEFINGWYVLVIISDLMTIIGSILKMEIKAKNLTNYDLCSIFLGTSTLLVWVGVIRYLGYFQAYNVLILTMQASLPKVLRFCACAGMIYLGYTFCGWIVLGPYHDKFENLNTVAECLFSLVNGDDMFATFAQIQQKSILVWLFSRLYLYSFISLFIYMILSLFIALITDSYDTIKKFQQNGFPETDLQEFLKECSSKEEYQKESSAFLSCICCRRRKRSDDHLIPIS
uniprot
proteins
function
FUNCTION: Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:19885840, PubMed:19940139). May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway (PubMed:17662026). May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840). Also functions as a Fe(2+) permeable channel (By similarity). {ECO:0000250|UniProtKB:Q8K595, ECO:0000269|PubMed:17662026, ECO:0000269|PubMed:19885840, ECO:0000269|PubMed:19940139, ECO:0000305}.
uniprot
proteins
mass_dalton
65942
uniprot
proteins
mutagenesis
MUTAGEN 424; /note="A->P: Constitutive active Ca(2+) permeable and inward rectifying channel."; /evidence="ECO:0000269|PubMed:19940139"; MUTAGEN 457; /note="F->L: Does not effect current amplitude; possible effect on regulation."; /evidence="ECO:0000269|PubMed:19940139"; MUTAGEN 463..464; /note="DD->KK: Blocks channel activity. Decreases recycling of internalized CD59 to the cell surface."; /evidence="ECO:0000269|PubMed:17662026, ECO:0000269|PubMed:19940139
uniprot
proteins
protein_family
MCOLN2 sub-subfamily
uniprot
proteins
protein_family
Polycystin subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
pubmed
12403827
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17662026
uniprot
proteins
pubmed
19885840
uniprot
proteins
pubmed
19940139
uniprot
proteins
pubmed
25130899
uniprot
proteins
sequence_length
566
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17662026}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F6RG56}. Late endosome membrane {ECO:0000269|PubMed:17662026}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F6RG56}. Lysosome membrane {ECO:0000269|PubMed:17662026}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F6RG56}. Recycling endosome membrane {ECO:0000269|PubMed:17662026}; Multi-pass membrane protein {ECO:0000250|UniProtKB:F6RG56}. Note=Localizes to recycling endosomes in activated macrophages and microglia. {ECO:0000250|UniProtKB:Q8K595}.
uniprot
proteins
transmembrane_region
TRANSMEM 66..86; /note="Helical"; /evidence="ECO:0000250|UniProtKB:F6RG56"; TRANSMEM 289..309; /note="Helical"; /evidence="ECO:0000250|UniProtKB:F6RG56"; TRANSMEM 347..367; /note="Helical"; /evidence="ECO:0000250|UniProtKB:F6RG56"; TRANSMEM 377..397; /note="Helical"; /evidence="ECO:0000250|UniProtKB:F6RG56"; TRANSMEM 420..440; /note="Helical"; /evidence="ECO:0000250|UniProtKB:F6RG56"; TRANSMEM 481..502; /note="Helical"; /evidence="ECO:0000250|UniProtKB:F6RG56
uniprot
proteins