OSBPL6
entrez
114880
canonical
uniprot
Q9BZF3
canonical
ensembl
ENSG00000079156
resolver
ensp
ENSP00000190611
resolver
ensp
ENSP00000318723
resolver
ensp
ENSP00000349591
resolver
ensp
ENSP00000352713
resolver
ensp
ENSP00000376293
resolver
ensp
ENSP00000387248
resolver
ensp
ENSP00000551626
resolver
ensp
ENSP00000551630
resolver
ensp
ENSP00000551633
resolver
ensp
ENSP00000551634
resolver
ensp
ENSP00000551635
resolver
ensp
ENSP00000551636
resolver
ensp
ENSP00000551639
resolver
ensp
ENSP00000551640
resolver
ensp
ENSP00000551641
resolver
ensp
ENSP00000551642
resolver
ensp
ENSP00000551643
resolver
ensp
ENSP00000551644
resolver
ensp
ENSP00000551645
resolver
ensp
ENSP00000551646
resolver
ensp
ENSP00000602990
resolver
ensp
ENSP00000602991
resolver
ensp
ENSP00000602992
resolver
ensp
ENSP00000602993
resolver
ensp
ENSP00000602994
resolver
ensp
ENSP00000616079
resolver
ensp
ENSP00000616085
resolver
ensp
ENSP00000616086
resolver
genesymbol
OSBPL6
resolver
genesymbol_syn
ORP6
resolver
hgnc
HGNC:16388
resolver
uniprot
B4DTW1
resolver
uniprot
C4AMC0
resolver
uniprot
C4AME4
resolver
uniprot
D3DPF6
resolver
uniprot
D3DPF7
resolver
uniprot
Q4ZG68
resolver
uniprot
Q53T68
resolver
uniprot
Q59H61
resolver
uniprot
Q7Z4Q1
resolver
uniprot
Q86V84
resolver
uniprot
Q8N9T0
resolver
uniprot
Q96SR1
resolver
uniprot_entry
OSBL6_HUMAN
resolver
uniprot_sec
B4DTW1
resolver
uniprot_sec
C4AMC0
resolver
uniprot_sec
C4AME4
resolver
uniprot_sec
D3DPF6
resolver
uniprot_sec
D3DPF7
resolver
uniprot_sec
Q4ZG68
resolver
uniprot_sec
Q53T68
resolver
uniprot_sec
Q59H61
resolver
uniprot_sec
Q7Z4Q1
resolver
uniprot_sec
Q86V84
resolver
uniprot_sec
Q8N9T0
resolver
uniprot_sec
Q96SR1
resolver
amino_acid_sequence
MSSDEKGISPAHKTSTPTHRSASSSTSSQRDSRQSIHILERTASSSTEPSVSRQLLEPEPVPLSKEADSWEIIEGLKIGQTNVQKPDKHEGFMLKKRKWPLKGWHKRFFVLDNGMLKYSKAPLDIQKGKVHGSIDVGLSVMSIKKKARRIDLDTEEHIYHLKVKSQDWFDAWVSKLRHHRLYRQNEIVRSPRDASFHIFPSTSTAESSPAANVSVMDGKMQPNSFPWQSPLPCSNSLPATCTTGQSKVAAWLQDSEEMDRCAEDLAHCQSNLVELSKLLQNLEILQRTQSAPNFTDMQANCVDISKKDKRVTRRWRTKSVSKDTKIQLQVPFSATMSPVRLHSSNPNLCADIEFQTPPSHLTDPLESSTDYTKLQEEFCLIAQKVHSLLKSAFNSIAIEKEKLKQMVSEQDHSKGHSTQMARLRQSLSQALNQNAELRSRLNRIHSESIICDQVVSVNIIPSPDEAGEQIHVSLPLSQQVANESRLSMSESVSEFFDAQEVLLSASSSENEASDDESYISDVSDNISEDNTSVADNISRQILNGELTGGAFRNGRRACLPAPCPDTSNINLWNILRNNIGKDLSKVSMPVELNEPLNTLQHLCEEMEYSELLDKASETDDPYERMVLVAAFAVSGYCSTYFRAGSKPFNPVLGETYECIREDKGFRFFSEQVSHHPPISACHCESKNFVFWQDIRWKNKFWGKSMEILPVGTLNVMLPKYGDYYVWNKVTTCIHNILSGRRWIEHYGEVTIRNTKSSVCICKLTFVKVNYWNSNMNEVQGVVIDQEGKAVYRLFGKWHEGLYCGVAPSAKCIWRPGSMPTNYELYYGFTRFAIELNELDPVLKDLLPPTDARFRPDQRFLEEGNLEAAASEKQRVEELQRSRRRYMEENNLEHIPKFFKKVIDANQREAWVSNDTYWELRKDPGFSKVDSPVLW
uniprot
proteins
function
FUNCTION: Regulates cellular transport and efflux of cholesterol (PubMed:26941018). Plays a role in phosphatidylinositol-4-phosphate (PI4P) turnover at the neuronal membrane. Localizes at the neurons plasma membrane-endoplasmic reticulum contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) from the endoplasmic reticulum for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) from the plasma membrane (By similarity). Binds via its PH domain PI4P, phosphatidylinositol-4,5-diphosphate, phosphatidylinositol-3,4,5-triphosphate, and phosphatidic acid (By similarity). Weakly binds 25-hydroxycholesterol (PubMed:17428193). {ECO:0000250|UniProtKB:Q8BXR9, ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:26941018}.
uniprot
proteins
mass_dalton
106306
uniprot
proteins
protein_family
OSBP family
uniprot
proteins
pubmed
11483621
uniprot
proteins
pubmed
11735225
uniprot
proteins
pubmed
14593528
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17428193
uniprot
proteins
pubmed
17525332
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
26941018
uniprot
proteins
pubmed
30028970
uniprot
proteins
sequence_length
934
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:14593528, ECO:0000269|PubMed:30028970}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:14593528, ECO:0000269|PubMed:26941018, ECO:0000269|PubMed:30028970}; Peripheral membrane protein {ECO:0000305}. Nucleus envelope {ECO:0000269|PubMed:14593528}. Cell membrane {ECO:0000269|PubMed:14593528, ECO:0000269|PubMed:30028970}; Peripheral membrane protein {ECO:0000305}. Endosome membrane {ECO:0000269|PubMed:26941018}; Peripheral membrane protein {ECO:0000305}. Note=Co-localizes with OSBPL3 at contact sites between the plasma membrane and the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q8BXR9}.
uniprot
proteins