Ca4
entrez
12351
canonical
uniprot
Q64444
canonical
ensembl
ENSMUSG00000000805
resolver
ensp
ENSMUSP00000099483
resolver
enst
ENSMUST00000103194
resolver
genesymbol
Ca4
resolver
genesymbol_syn
Car4
resolver
uniprot_entry
CAH4_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by acetazolamide. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MQLLLALLALAYVAPSTEDSGWCYEIQTKDPRSSCLGPEKWPGACKENQQSPINIVTARTKVNPRLTPFILVGYDQKQQWPIKNNQHTVEMTLGGGACIIGGDLPARYEAVQLHLHWSNGNDNGSEHSIDGRHFAMEMHIVHKKLTSSKEDSKDKFAVLAFMIEVGDKVNKGFQPLVEALPSISKPHSTSTVRESSLQDMLPPSTKMYTYFRYNGSLTTPNCDETVIWTVYKQPIKIHKNQFLEFSKNLYYDEDQKLNMKDNVRPLQPLGKRQVFKSHAPGQLLSLPLPTLLVPTLTCLVANFLQ
uniprot
proteins
ec_number
4.2.1.1
uniprot
proteins
function
FUNCTION: Catalyzes the reversible hydration of carbon dioxide into bicarbonate and protons and thus is essential to maintaining intracellular and extracellular pH. May stimulate the sodium/bicarbonate transporter activity of SLC4A4 that acts in pH homeostasis. It is essential for acid overload removal from the retina and retina epithelium, and acid release in the choriocapillaris in the choroid. {ECO:0000250|UniProtKB:P22748}.
uniprot
proteins
mass_dalton
34351
uniprot
proteins
protein_family
Alpha-carbonic anhydrase family
uniprot
proteins
pubmed
14567693
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8935991
uniprot
proteins
pubmed
9541386
uniprot
proteins
sequence_length
305
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P22748}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:P22748}.
uniprot
proteins