Pank4
entrez
269614
canonical
uniprot
Q80YV4
canonical
ensembl
ENSMUSG00000029056
resolver
ensp
ENSMUSP00000030931
resolver
ensp
ENSMUSP00000064330
resolver
ensp
ENSMUSP00000217531
resolver
genesymbol
Pank4
resolver
uniprot
B1AZN5
resolver
uniprot
B1AZN6
resolver
uniprot
Q7M751
resolver
uniprot
Q8BQE9
resolver
uniprot_entry
PANK4_MOUSE
resolver
uniprot_sec
B1AZN5
resolver
uniprot_sec
B1AZN6
resolver
uniprot_sec
Q7M751
resolver
uniprot_sec
Q8BQE9
resolver
activity_regulation
ACTIVITY REGULATION: Activity is strongly promoted by Co(2+), Ni(2+), Mg(2+) and Mn(2+). Activity is inhibited by EDTA. {ECO:0000250|UniProtKB:Q9NVE7}.
uniprot
proteins
amino_acid_sequence
MAERGASGGGSGGDSLDKSITLPPDEIFRNLENAKRFAIDIGGSLTKLAYYSTVQHKVAKVRSFDHPGKDVEQDHEPPYEISVQEEITARLHFIKFENTYMEACLDFIRDHLVNTETKVIQATGGGAYKFKDLIEEKLRLKVDKEDVMTCLIKGCNFVLKNIPHEAFMYQKDSDPEFRFQTNHPNIFPYLLVNIGSGVSIVKVETEDRFEWIGGSSIGGGTFWGLGALLTKTKKFDELLQLASRGRHANVDMLVQDIYGGAHQTLGLSGNLIASSFGKSATADREFSKEDMAKSLLHMISNDIGQLACLYAKLHGLDRVYFGGFFIRGHPVTMRTITYSINFFSKGEVQALFLRHEGYLGAIGAFLKGAEQDNPNQYSWGENYAASSGLMSTSPELCPTQRARSGTFDLLEMDRLERPLVNLPLLLDPSSYVPDTVDLTDDALARQYWLTCFEEALDGVVKRAVASQPESMDAVERAEKFRQKYWGKLQTLRHQPFAYGTLTVRSLLDTREHCLNEFNFPDPYSKVKQKENGLALKCFQSVTRSLDSLGWEERQLALVKGLLAGNVFDWGAKAVSDVLESDPQFGFEEAKRKLQERPWLVDSYTKWLQRLKGPPHKCALIFADNSGIDIILGVFPFVRELLFRGTEVILACNSGPALNDVTYSESLIVAERIAAMDPIICTALREDRLLLVQTGSSSPCLDLSLCTSRTTTCMVLPFAMWVLWTKLKSLVEKCLSPLSILLACSVLSAKSRLDKGLAVLVRERGADLVVIEGMGRAIHTNYHALLRCESLKLAVVKNAWLAERLGGQLFSVIFKYEVPTK
uniprot
proteins
ec_number
3.1.3.-
uniprot
proteins
function
FUNCTION: Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein. May play a role in the physiological regulation of CoA intracellular levels. {ECO:0000250|UniProtKB:Q9NVE7}.
uniprot
proteins
mass_dalton
91522
uniprot
proteins
protein_family
Phosphopantetheine phosphatase II subfamily
uniprot
proteins
protein_family
Type II pantothenate kinase family; Damage-control phosphatase family
uniprot
proteins
pubmed
11479594
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16800626
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30585370
uniprot
proteins
sequence_length
820
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q923S8}.
uniprot
proteins