AKAP7
entrez
9465
canonical
uniprot
O43687
canonical
uniprot
Q9P0M2
canonical
ensembl
ENSG00000118507
resolver
ensp
ENSP00000345149
resolver
ensp
ENSP00000405252
resolver
ensp
ENSP00000418208
resolver
ensp
ENSP00000506952
resolver
ensp
ENSP00000516708
resolver
ensp
ENSP00000794509
resolver
enst
ENST00000431975
resolver
enst
ENST00000683794
resolver
enst
ENST00000706999
resolver
genesymbol
AKAP7
resolver
genesymbol_syn
AKAP15
resolver
genesymbol_syn
AKAP18
resolver
hgnc
HGNC:377
resolver
uniprot
A0A804HI88
resolver
uniprot
A0A9L9PYJ6
resolver
uniprot
A8K2K6
resolver
uniprot
B4DUC3
resolver
uniprot
Q2TAJ5
resolver
uniprot
Q5TBR9
resolver
uniprot
Q5TBS0
resolver
uniprot
Q6P4D3
resolver
uniprot
Q9HCZ8
resolver
uniprot
Q9P0G4
resolver
uniprot_entry
A0A804HI88_HUMAN
resolver
uniprot_entry
A0A9L9PYJ6_HUMAN
resolver
uniprot_entry
AKA7A_HUMAN
resolver
uniprot_entry
AKA7G_HUMAN
resolver
uniprot_entry
Q2TAJ5_HUMAN
resolver
uniprot_entry
Q6P4D3_HUMAN
resolver
uniprot_sec
A8K2K6
resolver
uniprot_sec
B4DUC3
resolver
uniprot_sec
Q5TBR9
resolver
uniprot_sec
Q5TBS0
resolver
uniprot_sec
Q9HCZ8
resolver
uniprot_sec
Q9P0G4
resolver
amino_acid_sequence
MERPEAGGINSNECENVSRKKKMSEEFEANTMDSLVDMPFATVDIQDDCGITDEPQINLKRSQENEWVKSDQVKKRKKKRKDYQPNYFLSIPITNKEIIKGIKILQNAIIQQDERLAKAMVSDGSFHITLLVMQLLNEDEVNIGIDALLELKPFIEELLQGKHLTLPFQGIGTFGNQVGFVKLAEGDHVNSLLEIAETANRTFQEKGILVGESRSFKPHLTFMKLSKSPWLRKNGVKKIDPDLYEKFISHRFGEEILYRIDLCSMLKKKQSNGYYHCESSIVIGEKNGGEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKPGEGSSVKTEAADQNGNDNENNRK
uniprot
proteins
amino_acid_sequence
MGQLCCFPFSRDEGKISELESSSSAVLQRYSKDIPSWSSGEKNGGEPDDAELVRLSKRLVENAVLKAVQQYLEETQNKNKPGEGSSVKTEAADQNGNDNENNRK
uniprot
proteins
function
FUNCTION: Probably targets cAMP-dependent protein kinase (PKA) to the cellular membrane or cytoskeletal structures. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium. {ECO:0000269|PubMed:10613906, ECO:0000269|PubMed:17244820}.
uniprot
proteins
function
FUNCTION: Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium. {ECO:0000269|PubMed:10613906, ECO:0000269|PubMed:17244820, ECO:0000269|PubMed:9545239}.
uniprot
proteins
mass_dalton
11465
uniprot
proteins
mass_dalton
39518
uniprot
proteins
mutagenesis
MUTAGEN 2..6; /note="GQLCC->AQLAA: Abolishes membrane localization and affects its ability to inhibit ENaC activity in a sodium-dependent manner."; /evidence="ECO:0000269|PubMed:17244820
uniprot
proteins
pubmed
10613906
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17244820
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9545239
uniprot
proteins
sequence_length
104
uniprot
proteins
sequence_length
348
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:10613906}.
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform Alpha]: Lateral cell membrane; Lipid-anchor. Note=Targeted predominantly to the lateral membrane.; SUBCELLULAR LOCATION: [Isoform Beta]: Apical cell membrane; Lipid-anchor. Note=Targeted predominantly to the apical membrane.
uniprot
proteins