Ppp4c
entrez
56420
canonical
uniprot
P97470
canonical
ensembl
ENSMUSG00000030697
resolver
ensp
ENSMUSP00000032936
resolver
ensp
ENSMUSP00000146245
resolver
enst
ENSMUST00000032936
resolver
enst
ENSMUST00000206570
resolver
genesymbol
Ppp4c
resolver
genesymbol_syn
Ppp4
resolver
genesymbol_syn
Ppx
resolver
uniprot
P33172
resolver
uniprot
Q3UNF2
resolver
uniprot_entry
PP4C_MOUSE
resolver
uniprot_entry
Q3UNF2_MOUSE
resolver
uniprot_sec
P33172
resolver
amino_acid_sequence
MAEISDLDRQIEQLRRCELIKESEVKALCAKAREILVEESNVQRVDSPVTVCGDIHGQFYDLKELFRVGGDVPETNYLFMGDFVDRGFYSVETFLLLLALKVRYPDRITLIRGNHESRQITQVYGFYDECLRKYGSVTVWRYCTEIFDYLSLSAIIDGKIFCVHGGLSPSIQTLDQIRTIDRKQEVPHDGPMCDLLWSDPEDTTGWGVSPRGAGYLFGSDVVAQFNAANDIDMICRAHQLVMEGYKWHFNETVLTVWSAPNYCYRCGNVAAILELDEHLQKDFIIFEAAPQETRGIPSKKPVADYFL
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AX phosphorylated on Ser-140 (gamma-H2AX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (PubMed:18347064). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin (By similarity). {ECO:0000250|UniProtKB:P60510, ECO:0000269|PubMed:18347064}.
uniprot
proteins
mass_dalton
35080
uniprot
proteins
post_translational_modification
PTM: Methylation at the C-terminal Leu-307 is critical for interactions with regulatory subunits and functions in DNA repair. {ECO:0000250|UniProtKB:P60510}.; PTM: Ubiquitinated by the SCF(FBXO42) complex; leading to proteasomal degradation. {ECO:0000250|UniProtKB:P60510}.
uniprot
proteins
protein_family
PP-4 (PP-X) subfamily
uniprot
proteins
protein_family
PPP phosphatase family
uniprot
proteins
pubmed
11707325
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18347064
uniprot
proteins
pubmed
18715871
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9837938
uniprot
proteins
sequence_length
307
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
uniprot
proteins