Ptchd4
entrez
627626
canonical
uniprot
B9EKX1
canonical
ensembl
ENSMUSG00000042256
resolver
ensp
ENSMUSP00000047640
resolver
ensp
ENSMUSP00000156770
resolver
enst
ENSMUST00000048691
resolver
enst
ENSMUST00000232968
resolver
genesymbol
Ptchd4
resolver
genesymbol_syn
3110082D06Rik
resolver
uniprot
E9QMK6
resolver
uniprot_entry
E9QMK6_MOUSE
resolver
uniprot_entry
PTHD4_MOUSE
resolver
amino_acid_sequence
MCFLRRPGAPASWIWWRMLRQVLRRGLQSFCHRLGLCVSRHPVFFLTVPAVLTITFGLSALNRFQTEGDLERLVAPSHSLAKIERSLASSLFPLDQSKSQLYSDLHTPGRYGRVILLSSPGDNILLQAEGILQTHRAVMEMKVNHKGYNYTFSHLCVLRNQDKKCVLDDIISVLEDLRQAAVSNKTTARVQVRYPNTKLKDGRNSFIGHQLGGVVEVPNSKDQRVKSARAIQITYYLQTYGSATQDLIGEKWENEFCKLMRKLQEEHQDLQLYSLASFSLWRDFHKTSILTRSKVLVSLVLILTTATLSSSMKDCLRSKPFLGLLGVLTVCISIATAAGIFFITDGKYNSTLLGIPFFAMGHGTKGVFELLSGWRRTKENLPFKDRVADAYSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKIFCQNMCVSILLNYFYIFSFFGSCLVFAGQLEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSDGHQQTSHHETNPYQHHFIQHFLREHYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGASIINLLASDSPSVSYAMVQQKYFSNYSPVIGFYVYEPLEYWNSSVQEDLQRLCSGFTAVSWVEQYYQFLKTSNISANNKTDFISVLQSSFLKKPEFQHFRNDIIFSRAGDENNIIASRLYLVARTSRDKQKEVIEVLDKLRPLSLSKSIRFIVFNPSFVFTDHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLGNFWLILSVTSIELGVLGLMTLWNVDMDCISILCLIYTLNFAIDHCAPLLYTFVLATEHTRTQCIKSSLQEHGTAILQNITSFLIGLLPLLFVPSNLTFTLFKCLLLTGGCTLLHCFVILPVFLTFFPPSKKHHKKKKRAKRKEREEIECIEIQENPDHVTTV
uniprot
proteins
function
FUNCTION: Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down-regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4-expressing cells. {ECO:0000250|UniProtKB:Q6ZW05}.
uniprot
proteins
mass_dalton
103115
uniprot
proteins
protein_family
Patched family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
904
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 41..61; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 295..312; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 323..343; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 351..371; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 394..414; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 431..451; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 523..543; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 718..738; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 744..764; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 771..791; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 823..843; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 845..865; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins