Arhgef7
entrez
54126
canonical
uniprot
Q9ES28
canonical
ensembl
ENSMUSG00000031511
resolver
ensp
ENSMUSP00000074399
resolver
ensp
ENSMUSP00000096538
resolver
ensp
ENSMUSP00000106534
resolver
ensp
ENSMUSP00000263872
resolver
ensp
ENSMUSP00000263873
resolver
ensp
ENSMUSP00000263875
resolver
ensp
ENSMUSP00000263877
resolver
enst
ENSMUST00000074856
resolver
genesymbol
Arhgef7
resolver
genesymbol_syn
Kiaa0142
resolver
genesymbol_syn
Pak3bp
resolver
uniprot
A0A0R4J0X8
resolver
uniprot
O08757
resolver
uniprot
Q3UTS5
resolver
uniprot
Q6XPA5
resolver
uniprot
Q6ZQI5
resolver
uniprot
Q8C750
resolver
uniprot
Q91ZZ6
resolver
uniprot
Q9ES27
resolver
uniprot_entry
A0A0R4J0X8_MOUSE
resolver
uniprot_entry
ARHG7_MOUSE
resolver
uniprot_sec
O08757
resolver
uniprot_sec
Q3UTS5
resolver
uniprot_sec
Q6XPA5
resolver
uniprot_sec
Q6ZQI5
resolver
uniprot_sec
Q8C750
resolver
uniprot_sec
Q91ZZ6
resolver
uniprot_sec
Q9ES27
resolver
amino_acid_sequence
MNSAEQTVTWLITLGVLESPKKTISDPEVFLQASLKDGVVLCRLLERLLPGTIEKVYPEPRNESECLSNIREFLRACGASLRLETFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSSHSRTSKLLQSQYRSLDMTDNTNSQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTHNGRTGWFPSNYVREIKPSEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETEHEYSKELQSVLSTYLRPLQTSDKLSSANTSYLMGNLEEISSFQQVLVQSLEECTKSPEAQQRVGGCFLSLMPQMRTLYLAYCANHPSAVSVLTEHSEDLGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHPDRQDIQKSMTAFKNLSAQCQEVRKRKELELQILTEPIRSWEGDDIKTLGSVTYMSQVTIQCAGSEEKNERYLLLFPNLLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCTSQQDLHEWVEHLQKQTKVTSVSNPTIKPHSVPSHTLPSHPLTPSSKHADSKPVALTPAYHTLPHPSHHGTPHTTISWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFAVRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNHVLADDDQSSLDSLGRRSSLSRLEPSDLSEDSEYDSIWTAHSYRMGSASRSRKESAPQVLLPEEEKIIVEETKSNGQTVIEEKSLVDTVYALKDEVQELRQDNKKMKKSLEEEQRARKDLEKLVRKVLKNMNDPAWDETNL
uniprot
proteins
function
FUNCTION: Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. May function as a positive regulator of apoptosis. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons (By similarity). {ECO:0000250, ECO:0000269|PubMed:17093062}.
uniprot
proteins
mass_dalton
97056
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Ser-673 by CaMK1; enhancement of GEF activity and downstream activation of RAC1 (By similarity). Phosphorylated by PTK2/FAK1; this promotes interaction with RAC1. {ECO:0000250, ECO:0000269|PubMed:17093062}.
uniprot
proteins
pubmed
10428811
uniprot
proteins
pubmed
10860822
uniprot
proteins
pubmed
11266127
uniprot
proteins
pubmed
12153727
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15120616
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16307729
uniprot
proteins
pubmed
16959763
uniprot
proteins
pubmed
17093062
uniprot
proteins
pubmed
17114649
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18325335
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9207241
uniprot
proteins
sequence_length
862
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell junction, focal adhesion. Cell projection, ruffle. Cytoplasm, cell cortex. Cell projection, lamellipodium. Note=Detected at cell adhesions. A small proportion is detected at focal adhesions.
uniprot
proteins