PRDX5
entrez
25824
canonical
uniprot
P30044
canonical
ensembl
ENSG00000126432
resolver
ensp
ENSP00000265462
resolver
ensp
ENSP00000335334
resolver
ensp
ENSP00000335363
resolver
ensp
ENSP00000547513
resolver
genesymbol
PRDX5
resolver
genesymbol_syn
ACR1
resolver
hgnc
HGNC:9355
resolver
uniprot
A6NC19
resolver
uniprot
A6NG06
resolver
uniprot
B7ZLJ4
resolver
uniprot
B7ZVW3
resolver
uniprot
Q14CK0
resolver
uniprot
Q6IAF2
resolver
uniprot
Q9UBU5
resolver
uniprot
Q9UJU4
resolver
uniprot
Q9UKX4
resolver
uniprot_entry
PRDX5_HUMAN
resolver
uniprot_sec
A6NC19
resolver
uniprot_sec
A6NG06
resolver
uniprot_sec
B7ZLJ4
resolver
uniprot_sec
B7ZVW3
resolver
uniprot_sec
Q14CK0
resolver
uniprot_sec
Q6IAF2
resolver
uniprot_sec
Q9UBU5
resolver
uniprot_sec
Q9UJU4
resolver
uniprot_sec
Q9UKX4
resolver
amino_acid_sequence
MGLAGVCALRRSAGYILVGGAGGQSAAAAARRYSEGEWASGGVRSFSRAAAAMAPIKVGDAIPAVEVFEGEPGNKVNLAELFKGKKGVLFGVPGAFTPGCSKTHLPGFVEQAEALKAKGVQVVACLSVNDAFVTGEWGRAHKAEGKVRLLADPTGAFGKETDLLLDDSLVSIFGNRRLKRFSMVVQDGIVKALNVEPDGTGLTCSLAPNIISQL
uniprot
proteins
ec_number
1.11.1.24
uniprot
proteins
function
FUNCTION: Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. {ECO:0000269|PubMed:10514471, ECO:0000269|PubMed:10521424, ECO:0000269|PubMed:10751410, ECO:0000269|PubMed:31740833}.
uniprot
proteins
mass_dalton
22086
uniprot
proteins
mutagenesis
MUTAGEN 100; /note="C->S: Loss of antioxidant activity. Loss of S-palmitoylation."; /evidence="ECO:0000269|PubMed:10751410, ECO:0000269|PubMed:31740833"; MUTAGEN 125; /note="C->S: No change in antioxidant activity. No change in S-palmitoylation levels."; /evidence="ECO:0000269|PubMed:10751410, ECO:0000269|PubMed:31740833"; MUTAGEN 204; /note="C->S: Loss of antioxidant activity. No change in S-palmitoylation levels."; /evidence="ECO:0000269|PubMed:10751410, ECO:0000269|PubMed:31740833
uniprot
proteins
post_translational_modification
PTM: S-palmitoylated (PubMed:31740833). Palmitoylation occurs on the active site, inhibiting its reactivity; therefore PRDX5 palmitoylation status determines its antioxidant capacity (PubMed:31740833). {ECO:0000269|PubMed:31740833}.; PTM: [Isoform Mitochondrial]: S-palmitoylated (PubMed:31740833). Depalmitoylated by ABHD10 (PubMed:31740833). {ECO:0000269|PubMed:31740833}.
uniprot
proteins
protein_family
Peroxiredoxin family
uniprot
proteins
protein_family
Prx5 subfamily
uniprot
proteins
pubmed
10095767
uniprot
proteins
pubmed
10514471
uniprot
proteins
pubmed
10521424
uniprot
proteins
pubmed
10679306
uniprot
proteins
pubmed
10751410
uniprot
proteins
pubmed
10931946
uniprot
proteins
pubmed
11518528
uniprot
proteins
pubmed
1286669
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
18489898
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
20643143
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
31740833
uniprot
proteins
sequence_length
214
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform Mitochondrial]: Mitochondrion {ECO:0000269|PubMed:10521424, ECO:0000269|PubMed:10751410, ECO:0000269|PubMed:31740833}.; SUBCELLULAR LOCATION: [Isoform Cytoplasmic+peroxisomal]: Cytoplasm {ECO:0000269|PubMed:10514471, ECO:0000269|PubMed:10751410}. Peroxisome matrix {ECO:0000269|PubMed:10514471, ECO:0000269|PubMed:10521424, ECO:0000269|PubMed:10751410}. Note=Imported into peroxisomes via peroxisomal targeting signal 1 receptor PEX5. {ECO:0000269|PubMed:10514471}.
uniprot
proteins