FATE1
entrez
89885
canonical
uniprot
Q969F0
canonical
ensembl
ENSG00000147378
resolver
ensp
ENSP00000359375
resolver
ensp
ENSP00000610398
resolver
ensp
ENSP00000610399
resolver
enst
ENST00000370350
resolver
enst
ENST00000940339
resolver
enst
ENST00000940340
resolver
genesymbol
FATE1
resolver
genesymbol_syn
FATE
resolver
hgnc
HGNC:24683
resolver
uniprot_entry
FATE1_HUMAN
resolver
amino_acid_sequence
MAGGPPNTKAEMEMSLAEELNHGRQGENQEHLVIAEMMELGSRSRGASQKKQKLEQKAAGSASAKRVWNMTATRPKKMGSQLPKPRMLRESGHGDAHLQEYAGNFQGIRFHYDRNPGTDAVAQTSLEEFNVLEMEVMRRQLYAVNRRLRALEEQGATWRHRETLIIAVLVSASIANLWLWMNQ
uniprot
proteins
function
FUNCTION: Involved in the regulation of endoplasmic reticulum (ER)-mitochondria coupling. Negatively regulates the ER-mitochondria distance and Ca(2+) transfer from ER to mitochondria possibly implicating it in the regulation of apoptosis (PubMed:27402544). May collaborate with RNF183 to restrain BIK protein levels thus regulating apoptotic signaling (PubMed:26567849). {ECO:0000269|PubMed:27402544, ECO:0000305|PubMed:26567849}.
uniprot
proteins
mass_dalton
20712
uniprot
proteins
mutagenesis
MUTAGEN 151; /note="L->D: Impairs association with mitochondria."; /evidence="ECO:0000269|PubMed:27402544
uniprot
proteins
pubmed
11694338
uniprot
proteins
pubmed
12811541
uniprot
proteins
pubmed
12865919
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
26567849
uniprot
proteins
pubmed
27402544
uniprot
proteins
sequence_length
183
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:26567849, ECO:0000269|PubMed:27402544}. Mitochondrion outer membrane {ECO:0000269|PubMed:27402544}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:27402544}; Single-pass membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305|PubMed:27402544}. Note=Localized to specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. Also associated with the outer surface of mitochondria at sites that are not in close contact with the ER. {ECO:0000269|PubMed:27402544}.
uniprot
proteins
transmembrane_region
TRANSMEM 163..181; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins