Spink1
entrez
20730
canonical
uniprot
P09036
canonical
ensembl
ENSMUSG00000024503
resolver
ensp
ENSMUSP00000025381
resolver
enst
ENSMUST00000025381
resolver
genesymbol
Spink1
resolver
genesymbol_syn
Spink3
resolver
uniprot
Q5M9M3
resolver
uniprot_entry
ISK1_MOUSE
resolver
uniprot_sec
Q5M9M3
resolver
amino_acid_sequence
MKVAVIFLLSALALLSLAGNTFSAKVTGKEASCHDAVAGCPRIYDPVCGTDGITYANECVLCFENRKRIEPVLIRKGGPC
uniprot
proteins
function
FUNCTION: Serine protease inhibitor which exhibits anti-trypsin activity (PubMed:14645103, PubMed:22228629, PubMed:3428272). In the pancreas, protects against trypsin-catalyzed premature activation of zymogens (PubMed:16083722). {ECO:0000269|PubMed:14645103, ECO:0000269|PubMed:16083722, ECO:0000269|PubMed:22228629, ECO:0000269|PubMed:3428272}.; FUNCTION: In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production (PubMed:14645103, PubMed:16083722, PubMed:22228629, PubMed:9828198). {ECO:0000269|PubMed:14645103, ECO:0000269|PubMed:16083722, ECO:0000269|PubMed:22228629, ECO:0000269|PubMed:9828198}.
uniprot
proteins
mass_dalton
8488
uniprot
proteins
mutagenesis
MUTAGEN 42; /note="R->L: Abolishes trypsin inhibitor activity. No effect on sperm binding."; /evidence="ECO:0000269|PubMed:14645103"; MUTAGEN 44; /note="Y->V: Severely impairs sperm binding. No effect on trypsin inhibitor activity."; /evidence="ECO:0000269|PubMed:14645103"; MUTAGEN 45; /note="D->G: Fails to bind sperm. No effect on trypsin inhibitor activity."; /evidence="ECO:0000269|PubMed:14645103"; MUTAGEN 66; /note="R->G: No effect on trypsin inhibitor activity or sperm binding."; /evidence="ECO:0000269|PubMed:14645103"; MUTAGEN 67; /note="K->S: No effect on trypsin inhibitor activity or sperm binding."; /evidence="ECO:0000269|PubMed:14645103"; MUTAGEN 68; /note="R->T: No effect on trypsin inhibitor activity or sperm binding."; /evidence="ECO:0000269|PubMed:14645103
uniprot
proteins
pubmed
14645103
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16083722
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1929395
uniprot
proteins
pubmed
22228629
uniprot
proteins
pubmed
3428272
uniprot
proteins
pubmed
9828198
uniprot
proteins
sequence_length
80
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:1929395}.
uniprot
proteins