ABO
entrez
28
canonical
uniprot
P16442
canonical
ensembl
ENSG00000175164
resolver
ensembl
ENSG00000281879
resolver
ensp
ENSP00000494079
resolver
enst
ENST00000644422
resolver
genesymbol
ABO
resolver
hgnc
HGNC:79
resolver
uniprot
A0A089QDC1
resolver
uniprot
B0JDB9
resolver
uniprot
O14758
resolver
uniprot
Q14490
resolver
uniprot
Q53I57
resolver
uniprot
Q6ISD4
resolver
uniprot
Q6KFZ2
resolver
uniprot
Q70V27
resolver
uniprot
Q99484
resolver
uniprot
Q99485
resolver
uniprot
Q9NY01
resolver
uniprot
Q9UQ68
resolver
uniprot
Q9UQ69
resolver
uniprot
W6JLF7
resolver
uniprot_entry
A0A089QDC1_HUMAN
resolver
uniprot_entry
BGAT_HUMAN
resolver
uniprot_entry
W6JLF7_HUMAN
resolver
uniprot_sec
B0JDB9
resolver
uniprot_sec
O14758
resolver
uniprot_sec
Q14490
resolver
uniprot_sec
Q53I57
resolver
uniprot_sec
Q6ISD4
resolver
uniprot_sec
Q6KFZ2
resolver
uniprot_sec
Q70V27
resolver
uniprot_sec
Q99484
resolver
uniprot_sec
Q99485
resolver
uniprot_sec
Q9NY01
resolver
uniprot_sec
Q9UQ68
resolver
uniprot_sec
Q9UQ69
resolver
amino_acid_sequence
MAEVLRTLAGKPKCHALRPMILFLIMLVLVLFGYGVLSPRSLMPGSLERGFCMAVREPDHLQRVSLPRMVYPQPKVLTPCRKDVLVVTPWLAPIVWEGTFNIDILNEQFRLQNTTIGLTVFAIKKYVAFLKLFLETAEKHFMVGHRVHYYVFTDQPAAVPRVTLGTGRQLSVLEVRAYKRWQDVSMRRMEMISDFCERRFLSEVDYLVCVDVDMEFRDHVGVEILTPLFGTLHPGFYGSSREAFTYERRPQSQAYIPKDEGDFYYLGGFFGGSVQEVQRLTRACHQAMMVDQANGIEAVWHDESHLNKYLLRHKPTKVLSPEYLWDQQLLGWPAVLRKLRFTAVPKNHQAVRNP
uniprot
proteins
ec_number
2.4.1.37
uniprot
proteins
ec_number
2.4.1.40
uniprot
proteins
function
FUNCTION: This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of N-acetyl-alpha-D-galactosamine (GalNAc)) or to the B antigen (by addition of galactose (Gal)), whereas O individuals lack such activity and express the H antigen precursor unmodified.; FUNCTION: Catalyzes the transfer of GalNAc or Gal in an alpha1,3 linkage to the terminal Gal of all five types of naturally occurring H antigens, forming the antigenic structures of the A and B blood groups. {ECO:0000269|PubMed:12198488, ECO:0000269|PubMed:12529355, ECO:0000269|PubMed:16326711, ECO:0000269|PubMed:17259183, ECO:0000269|PubMed:2121736, ECO:0000269|Ref.20}.
uniprot
proteins
mass_dalton
40934
uniprot
proteins
mutagenesis
MUTAGEN 214; /note="M->T,V: Alters substrate specificity so that both UDP-N-acetyl-D-galactosamine and UDP-galactose are utilized."; /evidence="ECO:0000269|PubMed:17259183"; MUTAGEN 234; /note="P->S: Alters donor nucleotide-sugar specificity switching from UDP-galactose to UDP-N-acetyl-D-galactosamine."; /evidence="ECO:0000269|PubMed:12529355"; MUTAGEN 303; /note="E->A: Almost complete loss of specific activity in group B transferase."; /evidence="ECO:0000269|PubMed:12198488
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000305}.
uniprot
proteins
post_translational_modification
PTM: The soluble form derives from the membrane form by proteolytic processing.
uniprot
proteins
protein_family
Glycosyltransferase 6 family
uniprot
proteins
pubmed
10462501
uniprot
proteins
pubmed
12198488
uniprot
proteins
pubmed
12529355
uniprot
proteins
pubmed
12829588
uniprot
proteins
pubmed
12972418
uniprot
proteins
pubmed
1449469
uniprot
proteins
pubmed
15104652
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15475562
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16326711
uniprot
proteins
pubmed
16533287
uniprot
proteins
pubmed
17259183
uniprot
proteins
pubmed
17764507
uniprot
proteins
pubmed
18513251
uniprot
proteins
pubmed
2104828
uniprot
proteins
pubmed
2121736
uniprot
proteins
pubmed
2333095
uniprot
proteins
pubmed
7598760
uniprot
proteins
pubmed
7779106
uniprot
proteins
pubmed
8839869
uniprot
proteins
pubmed
9800297
uniprot
proteins
sequence_length
354
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein {ECO:0000269|PubMed:18513251}. Secreted. Note=Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
uniprot
proteins
transmembrane_region
TRANSMEM 33..53; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins