HTR1E
entrez
3354
canonical
uniprot
P28566
canonical
ensembl
ENSG00000168830
resolver
ensp
ENSP00000307766
resolver
ensp
ENSP00000632087
resolver
ensp
ENSP00000632088
resolver
ensp
ENSP00000632089
resolver
ensp
ENSP00000632090
resolver
enst
ENST00000305344
resolver
enst
ENST00000962028
resolver
enst
ENST00000962029
resolver
enst
ENST00000962030
resolver
enst
ENST00000962031
resolver
genesymbol
HTR1E
resolver
hgnc
HGNC:5291
resolver
uniprot
E1P503
resolver
uniprot
Q9P1Y1
resolver
uniprot_entry
5HT1E_HUMAN
resolver
uniprot_sec
E1P503
resolver
uniprot_sec
Q9P1Y1
resolver
amino_acid_sequence
MNITNCTTEASMAIRPKTITEKMLICMTLVVITTLTTLLNLAVIMAIGTTKKLHQPANYLICSLAVTDLLVAVLVMPLSIIYIVMDRWKLGYFLCEVWLSVDMTCCTCSILHLCVIALDRYWAITNAIEYARKRTAKRAALMILTVWTISIFISMPPLFWRSHRRLSPPPSQCTIQHDHVIYTIYSTLGAFYIPLTLILILYYRIYHAAKSLYQKRGSSRHLSNRSTDSQNSFASCKLTQTFCVSDFSTSDPTTEFEKFHASIRIPPFDNDLDHPGERQQISSTRERKAARILGLILGAFILSWLPFFIKELIVGLSIYTVSSEVADFLTWLGYVNSLINPLLYTSFNEDFKLAFKKLIRCREHT
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:14744596, PubMed:1513320, PubMed:1608964, PubMed:1733778, PubMed:21422162, PubMed:33762731). Also functions as a receptor for various alkaloids and psychoactive substances (PubMed:14744596, PubMed:1513320, PubMed:1608964, PubMed:1733778, PubMed:21422162, PubMed:33762731). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:14744596, PubMed:1513320, PubMed:1608964, PubMed:1733778, PubMed:21422162, PubMed:33762731). HTR1E is coupled to G(i)/G(o) G alpha proteins and mediates inhibitory neurotransmission by inhibiting adenylate cyclase activity (PubMed:33762731, PubMed:35610220). {ECO:0000269|PubMed:14744596, ECO:0000269|PubMed:1513320, ECO:0000269|PubMed:1608964, ECO:0000269|PubMed:1733778, ECO:0000269|PubMed:21422162, ECO:0000269|PubMed:33762731, ECO:0000269|PubMed:35610220}.
uniprot
proteins
mass_dalton
41682
uniprot
proteins
mutagenesis
MUTAGEN 311; /note="E->A: Increased G(i)/(o)-coupled receptor activity."; /evidence="ECO:0000269|PubMed:35610220
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10391209
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14744596
uniprot
proteins
pubmed
15014171
uniprot
proteins
pubmed
1513320
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1608964
uniprot
proteins
pubmed
1733778
uniprot
proteins
pubmed
18476671
uniprot
proteins
pubmed
20945968
uniprot
proteins
pubmed
21422162
uniprot
proteins
pubmed
33762731
uniprot
proteins
pubmed
35610220
uniprot
proteins
sequence_length
365
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14744596, ECO:0000269|PubMed:1513320, ECO:0000269|PubMed:1608964, ECO:0000269|PubMed:1733778, ECO:0000269|PubMed:21422162}; Multi-pass membrane protein {ECO:0000269|PubMed:14744596, ECO:0000269|PubMed:1513320, ECO:0000269|PubMed:1608964, ECO:0000269|PubMed:1733778, ECO:0000269|PubMed:21422162}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..45; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:33762731, ECO:0007744|PDB:7E33"; TRANSMEM 60..84; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:33762731, ECO:0007744|PDB:7E33"; TRANSMEM 93..118; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:33762731, ECO:0007744|PDB:7E33"; TRANSMEM 139..157; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:33762731, ECO:0007744|PDB:7E33"; TRANSMEM 180..203; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:33762731, ECO:0007744|PDB:7E33"; TRANSMEM 292..316; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:33762731, ECO:0007744|PDB:7E33"; TRANSMEM 323..345; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:33762731, ECO:0007744|PDB:7E33
uniprot
proteins