PLAT
entrez
5327
canonical
uniprot
P00750
canonical
ensembl
ENSG00000104368
resolver
ensp
ENSP00000220809
resolver
ensp
ENSP00000270188
resolver
ensp
ENSP00000429401
resolver
enst
ENST00000524009
resolver
genesymbol
PLAT
resolver
hgnc
HGNC:9051
resolver
uniprot
A8K022
resolver
uniprot
B2R8E8
resolver
uniprot
B4DN26
resolver
uniprot
F6W3T7
resolver
uniprot
Q15103
resolver
uniprot
Q503B0
resolver
uniprot
Q6PJA5
resolver
uniprot
Q7Z7N2
resolver
uniprot
Q86YK8
resolver
uniprot
Q9BU99
resolver
uniprot
Q9BZW1
resolver
uniprot_entry
B4DN26_HUMAN
resolver
uniprot_entry
F6W3T7_HUMAN
resolver
uniprot_entry
TPA_HUMAN
resolver
uniprot_sec
A8K022
resolver
uniprot_sec
B2R8E8
resolver
uniprot_sec
Q15103
resolver
uniprot_sec
Q503B0
resolver
uniprot_sec
Q6PJA5
resolver
uniprot_sec
Q7Z7N2
resolver
uniprot_sec
Q86YK8
resolver
uniprot_sec
Q9BU99
resolver
uniprot_sec
Q9BZW1
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by SERPINA5 (PubMed:10340997). Inhibited by SERPINE1 (PubMed:21925150). {ECO:0000269|PubMed:10340997, ECO:0000269|PubMed:21925150}.
uniprot
proteins
amino_acid_sequence
MDAMKRGLCCVLLLCGAVFVSPSQEIHARFRRGARSYQVICRDEKTQMIYQQHQSWLRPVLRSNRVEYCWCNSGRAQCHSVPVKSCSEPRCFNGGTCQQALYFSDFVCQCPEGFAGKCCEIDTRATCYEDQGISYRGTWSTAESGAECTNWNSSALAQKPYSGRRPDAIRLGLGNHNYCRNPDRDSKPWCYVFKAGKYSSEFCSTPACSEGNSDCYFGNGSAYRGTHSLTESGASCLPWNSMILIGKVYTAQNPSAQALGLGKHNYCRNPDGDAKPWCHVLKNRRLTWEYCDVPSCSTCGLRQYSQPQFRIKGGLFADIASHPWQAAIFAKHRRSPGERFLCGGILISSCWILSAAHCFQERFPPHHLTVILGRTYRVVPGEEEQKFEVEKYIVHKEFDDDTYDNDIALLQLKSDSSRCAQESSVVRTVCLPPADLQLPDWTECELSGYGKHEALSPFYSERLKEAHVRLYPSSRCTSQHLLNRTVTDNMLCAGDTRSGGPQANLHDACQGDSGGPLVCLNDGRMTLVGIISWGLGCGQKDVPGVYTKVTNYLDWIRDNMRP
uniprot
proteins
disease_involvement
DISEASE: Note=Increased activity of TPA results in increased fibrinolysis of fibrin blood clots that is associated with excessive bleeding. Defective release of TPA results in hypofibrinolysis that can lead to thrombosis or embolism. {ECO:0000269|PubMed:1762144}.
uniprot
proteins
ec_number
3.4.21.68
uniprot
proteins
function
FUNCTION: Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy (By similarity). {ECO:0000250|UniProtKB:P19637}.
uniprot
proteins
mass_dalton
62917
uniprot
proteins
post_translational_modification
PTM: The single chain, almost fully active enzyme, can be further processed into a two-chain fully active form by a cleavage after Arg-310 catalyzed by plasmin, tissue kallikrein or factor Xa.; PTM: Differential cell-specific N-linked glycosylation gives rise to two glycoforms, type I (glycosylated at Asn-219) and type II (not glycosylated at Asn-219). The single chain type I glycoform is less readily converted into the two-chain form by plasmin, and the two-chain type I glycoform has a lower activity than the two-chain type II glycoform in the presence of fibrin. {ECO:0000269|PubMed:1900431}.; PTM: N-glycosylation of Asn-152; the bound oligomannosidic glycan is involved in the interaction with the mannose receptor. {ECO:0000269|PubMed:1900431}.; PTM: Characterization of O-linked glycan was studied in Bowes melanoma cell line. {ECO:0000269|PubMed:1900431}.
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
10340997
uniprot
proteins
pubmed
11384978
uniprot
proteins
pubmed
1310033
uniprot
proteins
pubmed
1368681
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14759258
uniprot
proteins
pubmed
15053742
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1602484
uniprot
proteins
pubmed
1645336
uniprot
proteins
pubmed
1762144
uniprot
proteins
pubmed
1900431
uniprot
proteins
pubmed
1901789
uniprot
proteins
pubmed
2107528
uniprot
proteins
pubmed
21925150
uniprot
proteins
pubmed
2513186
uniprot
proteins
pubmed
2558718
uniprot
proteins
pubmed
2824147
uniprot
proteins
pubmed
3009482
uniprot
proteins
pubmed
3090401
uniprot
proteins
pubmed
3133640
uniprot
proteins
pubmed
3161893
uniprot
proteins
pubmed
39294191
uniprot
proteins
pubmed
6089198
uniprot
proteins
pubmed
6337343
uniprot
proteins
pubmed
6433976
uniprot
proteins
pubmed
6572897
uniprot
proteins
pubmed
6682760
uniprot
proteins
pubmed
7582899
uniprot
proteins
pubmed
8613982
uniprot
proteins
pubmed
9305622
uniprot
proteins
sequence_length
562
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space.
uniprot
proteins