FZD10
entrez
11211
canonical
uniprot
Q9ULW2
canonical
ensembl
ENSG00000111432
resolver
ensp
ENSP00000229030
resolver
enst
ENST00000229030
resolver
genesymbol
FZD10
resolver
hgnc
HGNC:4039
resolver
uniprot
Q6NSL8
resolver
uniprot_entry
FZD10_HUMAN
resolver
uniprot_entry
Q6NSL8_HUMAN
resolver
amino_acid_sequence
MQRPGPRLWLVLQVMGSCAAISSMDMERPGDGKCQPIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLHEFAPLVEYGCHGHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWPDSLDCRKLPNKNDPNYLCMEAPNNGSDEPTRGSGLFPPLFRPQRPHSAQEHPLKDGGPGRGGCDNPGKFHHVEKSASCAPLCTPGVDVYWSREDKRFAVVWLAIWAVLCFFSSAFTVLTFLIDPARFRYPERPIIFLSMCYCVYSVGYLIRLFAGAESIACDRDSGQLYVIQEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLIPLACYLVIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGLFSVLYTVPATCVIACYFYERLNMDYWKILAAQHKCKMNNQTKTLDCLMAASIPAVEIFMVKIFMLLVVGITSGMWIWTSKTLQSWQQVCSRRLKKKSRRKPASVITSGGIYKKAQHPQKTHHGKYEIPAQSPTCV
uniprot
proteins
function
FUNCTION: Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). {ECO:0000250|UniProtKB:Q8BKG4, ECO:0000305}.
uniprot
proteins
mass_dalton
65336
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. {ECO:0000250}.
uniprot
proteins
protein_family
G protein-coupled receptor Fz/Smo family
uniprot
proteins
pubmed
10448064
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19188438
uniprot
proteins
pubmed
9707618
uniprot
proteins
sequence_length
581
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:19188438}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 226..246; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 263..283; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 312..332; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 352..372; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 394..414; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 444..464; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 503..523; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins