CRCP
entrez
27297
canonical
uniprot
O75575
canonical
ensembl
ENSG00000241258
resolver
ensp
ENSP00000340044
resolver
ensp
ENSP00000378736
resolver
ensp
ENSP00000381674
resolver
ensp
ENSP00000388653
resolver
genesymbol
CRCP
resolver
hgnc
HGNC:17888
resolver
uniprot
A8MUZ4
resolver
uniprot
A8MW23
resolver
uniprot
B2R4H4
resolver
uniprot
B4E198
resolver
uniprot
Q3KRA3
resolver
uniprot
Q5HYF1
resolver
uniprot
Q8IXL4
resolver
uniprot_entry
RPC9_HUMAN
resolver
uniprot_sec
A8MUZ4
resolver
uniprot_sec
A8MW23
resolver
uniprot_sec
B2R4H4
resolver
uniprot_sec
B4E198
resolver
uniprot_sec
Q3KRA3
resolver
uniprot_sec
Q5HYF1
resolver
uniprot_sec
Q8IXL4
resolver
amino_acid_sequence
MEVKDANSALLSNYEVFQLLTDLKEQRKESGKNKHSSGQQNLNTITYETLKYISKTPCRHQSPEIVREFLTALKSHKLTKAEKLQLLNHRPVTAVEIQLMVEESEERLTEEQIEALLHTVTSILPAEPEAEQKKNTNSNVAMDEEDPA
uniprot
proteins
function
FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:20413673, PubMed:33558764, PubMed:34675218). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation (By similarity) (PubMed:20413673, PubMed:33558764, PubMed:33558766, PubMed:34675218). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (PubMed:19609254, PubMed:19631370). {ECO:0000250|UniProtKB:Q9C0Z9, ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370, ECO:0000269|PubMed:20413673, ECO:0000269|PubMed:33558764, ECO:0000269|PubMed:33558766, ECO:0000269|PubMed:34675218}.; FUNCTION: Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues. {ECO:0000250|UniProtKB:O35427}.
uniprot
proteins
mass_dalton
16871
uniprot
proteins
protein_family
Eukaryotic RPC9 RNA polymerase subunit family
uniprot
proteins
pubmed
10067875
uniprot
proteins
pubmed
12391170
uniprot
proteins
pubmed
12482973
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16344560
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19609254
uniprot
proteins
pubmed
19631370
uniprot
proteins
pubmed
20413673
uniprot
proteins
pubmed
33335104
uniprot
proteins
pubmed
33558764
uniprot
proteins
pubmed
33558766
uniprot
proteins
pubmed
33674783
uniprot
proteins
pubmed
34675218
uniprot
proteins
sequence_length
148
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:33335104}. Cell membrane {ECO:0000250|UniProtKB:O35427}; Peripheral membrane protein {ECO:0000250|UniProtKB:O35427}; Cytoplasmic side {ECO:0000250|UniProtKB:O35427}.
uniprot
proteins