Tnfsf11
entrez
117516
canonical
uniprot
Q9ESE2
canonical
ensembl
ENSRNOG00000071047
resolver
ensp
ENSRNOP00000078615
resolver
enst
ENSRNOT00000107778
resolver
genesymbol
Tnfsf11
resolver
genesymbol_syn
Opgl
resolver
genesymbol_syn
Rankl
resolver
genesymbol_syn
Trance
resolver
uniprot
D3ZXV1
resolver
uniprot
G3V794
resolver
uniprot
Q91ZI9
resolver
uniprot_entry
G3V794_RAT
resolver
uniprot_entry
TNF11_RAT
resolver
uniprot_sec
D3ZXV1
resolver
uniprot_sec
Q91ZI9
resolver
amino_acid_sequence
MRRANRDYGKYLRGSEEMGSCPGVPHEGPLHPAPSAPAPAPPPAASRFMFLALLGLGLGQVVCSIALFLYFRAQMDPNRISEDSTRCFYRILRLRENTGLQDSTLESEDTEALPDSCRRMKQAFQGAVQRELQHIVGPQRFSGVPAMMEGSWLDVARRGKPEAQPFAHLTINAADIPSGSHKVSLSSWYHDRGWAKISNMTLSNGKLRVNQDGFYYLYANICFRHHETSGSVPADYLQLMVYVVKTSIKIPSSHNLMKGGSTKNWSGNSEFHFYSINVGGFFKLRAGEEISVQVSNPSLLDPDQDATYFGAFKVQDID
uniprot
proteins
function
FUNCTION: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy. Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation. {ECO:0000250|UniProtKB:O14788, ECO:0000250|UniProtKB:O35235}.
uniprot
proteins
mass_dalton
35370
uniprot
proteins
post_translational_modification
PTM: The soluble form derives from the membrane form by proteolytic processing. {ECO:0000250}.
uniprot
proteins
protein_family
Tumor necrosis factor family
uniprot
proteins
pubmed
11092398
uniprot
proteins
pubmed
11804028
uniprot
proteins
sequence_length
318
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Tumor necrosis factor ligand superfamily member 11, soluble form]: Secreted {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 48..68; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins