Q497V6
uniprot
Q497V6
canonical
amino_acid_sequence
MTHTRRKSLPMLSSGPTGRGEPLQMEDSNMEQGTEDVEPGMPESPGHLTGRRKNYPLRKRSLVPEKPKACKVLLTRLENVAGPRSADEADELPPDLPKPPSPTSSSEDAGLVQPRKRRLASLNAEALNNLLLEREETSSLAGARRSRGGDPHRSRDRATGSWSFSKKRPRLGDLGEGSRDLSPELAPDEGARRDGDPAPKRLASLNAAAFLKLSQERELPLRPSRAQAEADGRSTEPLAPRILRPKVNGKNCPKARQGAGSGEATGPPNWQEQPDERWPSAPPHGPPTQPSHQAPGKALENPLRPNLPLLMGGQAALKPEPGRPGEESPAPKQELHQPSFPAPQLSPLPMPGNPADYSGPCGGPELTALGSFYLYCGQDGLQCGAYSPCPMLPEGKLSPVAAPNEGLLMAPSSVPSGVPFQHPPWSAPRYCSSEDTGANGYSICGVLPLSLTHIGTTCGGCPYKMPFTAEGCRSLGQLEFPLPEAGHPASPAHPLLGCPVPSVPPAAEPIPHLQTPISEPQTVARACPQSAKPPSGSKSGLRTGSSCRHTVRSKAARRPSHPKQPRAQRPRPRRRRRRRTNGWVPVGAACEKAVYVLDEPEPAIRKSYQAVERHGETIRVRDTVLLKSGPRKTSTPYVAKISALWENPESGELMMSLLWYYRPEHLQGGRSPSMHEPLQNEVFASRHQDQNSVACIEEKCYVLTFAEYCRFCAMAKRRGEGLPSRKTALVPPSADYSTPPHRTVPEDTDPELVFLCRHVYDFRHGRILKNPQ
uniprot
proteins
function
FUNCTION: Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins (By similarity). {ECO:0000250|UniProtKB:Q8TBE0}.
uniprot
proteins
mass_dalton
83871
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated in a FBXO11-dependent manner; leading to degradation. {ECO:0000250|UniProtKB:Q8TBE0}.
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
772
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus. Chromosome. Note=Localizes to heterochromatin and inactive X chromosome. Colocalizes with histone H3 trimethylated at 'Lys-27' (H3K27me3) (By similarity). {ECO:0000250|UniProtKB:Q8TBE0}.
uniprot
proteins