Six2
entrez
20472
canonical
uniprot
Q62232
canonical
ensembl
ENSMUSG00000024134
resolver
ensp
ENSMUSP00000125871
resolver
ensp
ENSMUSP00000278369
resolver
enst
ENSMUST00000163568
resolver
genesymbol
Six2
resolver
uniprot
P70179
resolver
uniprot_entry
SIX2_MOUSE
resolver
uniprot_sec
P70179
resolver
amino_acid_sequence
MSMLPTFGFTQEQVACVCEVLQQGGNIERLGRFLWSLPACEHLHKNESVLKAKAVVAFHRGNFRELYKILESHQFSPHNHAKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSYCFKEKSRSVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENSENSNSSSHNPLASSLNGSGKSVLGSSEDEKTPSGTPDHSSSSPALLLSPPPPPGLPSLHSLGHPPGPSAVPVPVPGGGGADPLQHHHSLQDSILNPMSANLVDLGS
uniprot
proteins
function
FUNCTION: Transcription factor that plays an important role in the development of several organs, including kidney, skull and stomach. During kidney development, maintains cap mesenchyme multipotent nephron progenitor cells in an undifferentiated state by opposing the inductive signals emanating from the ureteric bud and cooperates with WNT9B to promote renewing progenitor cells proliferation. Acts through its interaction with TCF7L2 and OSR1 in a canonical Wnt signaling independent manner preventing transcription of differentiation genes in cap mesenchyme such as WNT4. Also acts independently of OSR1 to activate expression of many cap mesenchyme genes, including itself, GDNF and OSR1. During craniofacial development plays a role in growth and elongation of the cranial base through regulation of chondrocyte differentiation (PubMed:20515681). During stomach organogenesis, controls pyloric sphincter formation and mucosal growth through regulation of a gene network including NKX2-5, BMPR1B, BMP4, SOX9 and GREM1 (PubMed:19660448). During branchial arch development, acts to mediate HOXA2 control over the insulin-like growth factor pathway (PubMed:18321982). May also be involved in limb tendon and ligament development (PubMed:7720577). Plays a role in cell proliferation and migration (By similarity). {ECO:0000250|UniProtKB:Q9NPC8, ECO:0000269|PubMed:17036046, ECO:0000269|PubMed:18321982, ECO:0000269|PubMed:18682239, ECO:0000269|PubMed:19660448, ECO:0000269|PubMed:20515681, ECO:0000269|PubMed:21350016, ECO:0000269|PubMed:22902740, ECO:0000269|PubMed:24598167, ECO:0000269|PubMed:7720577}.
uniprot
proteins
mass_dalton
32718
uniprot
proteins
protein_family
SIX/Sine oculis homeobox family
uniprot
proteins
pubmed
11734542
uniprot
proteins
pubmed
12215533
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17036046
uniprot
proteins
pubmed
18321982
uniprot
proteins
pubmed
18682239
uniprot
proteins
pubmed
19660448
uniprot
proteins
pubmed
19716816
uniprot
proteins
pubmed
20515681
uniprot
proteins
pubmed
21350016
uniprot
proteins
pubmed
22902740
uniprot
proteins
pubmed
24598167
uniprot
proteins
pubmed
7720577
uniprot
proteins
pubmed
8814301
uniprot
proteins
sequence_length
296
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8814301}.
uniprot
proteins