Mapk6
entrez
58840
canonical
uniprot
P27704
canonical
ensembl
ENSRNOG00000009381
resolver
ensembl
ENSRNOG00055007320
resolver
ensembl
ENSRNOG00060017014
resolver
ensembl
ENSRNOG00065016898
resolver
ensp
ENSRNOP00000013053
resolver
ensp
ENSRNOP00055009675
resolver
ensp
ENSRNOP00060023424
resolver
ensp
ENSRNOP00065022301
resolver
enst
ENSRNOT00000013053
resolver
enst
ENSRNOT00055012198
resolver
enst
ENSRNOT00060029098
resolver
enst
ENSRNOT00065028204
resolver
genesymbol
Mapk6
resolver
genesymbol_syn
Erk3
resolver
genesymbol_syn
Prkm6
resolver
uniprot
Q32LY4
resolver
uniprot_entry
MK06_RAT
resolver
uniprot_sec
Q32LY4
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation at Ser-189. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MAEKFESLMNIHGFDLGSRYMDLKPLGCGGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALREIKIIRRLDHDNIVKVFEILGPSGSQLTDDVGSLTELNSVYIVQEYMETDLANVLEQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKIGDFGLARIMDPHYSHKGHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHKPLTQLLPGISREALDFLEQILTFSPMDRLTAEEALSHPYMSIYSFPTDEPISSHPFHIEDEVDDILLMDETHSHIYNWERYHDCQFSEHDWPIHNNFDIDEVQLDPRALSDVTDEEEVQVDPRKYLDGDREKYLEDPAFDTSYSAEPCWQYPDHHENKYCDLECSHTCNYKTRSPSYLDNLVWRESEVNHYYEPKLIIDLSNWKEQSKDKSDKRGKSKCERNGLVKAQIALEEASQQLAERERGQGFDFDAFIAGTVQLSAQRESADVVDKLNDLNSSVSQLEMKSLISKSVSREKQEKGRANLAQLGALYQPSWESQFVSGGEECFLISQFCCEVRKDEHVEKENTYTSYLDKFFSRKEDSEMLETEPVEEGKRGERGREAGLLSSGGEFLLSRQLESIGTPQFHSPGGSPLKSIQATLTPSAMKSSPQIPHKTYSNILKHLN
uniprot
proteins
ec_number
2.7.11.24
uniprot
proteins
function
FUNCTION: Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
82275
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-189 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites (By similarity). {ECO:0000250}.; PTM: Ubiquitination at Met-1 leads to degradation by the proteasome pathway. {ECO:0000250}.
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
MAP kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2032290
uniprot
proteins
sequence_length
720
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocates to the cytoplasm following interaction with MAPKAPK5. {ECO:0000250}.
uniprot
proteins