INS
entrez
3630
canonical
uniprot
P01308
canonical
ensembl
ENSG00000254647
resolver
ensp
ENSP00000250971
resolver
ensp
ENSP00000370731
resolver
ensp
ENSP00000380432
resolver
enst
ENST00000250971
resolver
enst
ENST00000381330
resolver
enst
ENST00000397262
resolver
genesymbol
INS
resolver
hgnc
HGNC:6081
resolver
uniprot
I3WAC9
resolver
uniprot
Q5EEX2
resolver
uniprot_entry
I3WAC9_HUMAN
resolver
uniprot_entry
INS_HUMAN
resolver
uniprot_sec
Q5EEX2
resolver
amino_acid_sequence
MALWMRLLPLLALLALWGPDPAAAFVNQHLCGSHLVEALYLVCGERGFFYTPKTRREAEDLQVGQVELGGGPGAGSLQPLALEGSLQKRGIVEQCCTSICSLYQLENYCN
uniprot
proteins
disease_involvement
DISEASE: Hyperproinsulinemia (HPRI) [MIM:616214]: An autosomal dominant condition characterized by elevated levels of serum proinsulin-like material. {ECO:0000269|PubMed:1601997, ECO:0000269|PubMed:2196279, ECO:0000269|PubMed:3470784, ECO:0000269|PubMed:4019786, ECO:0000269|PubMed:6312455, ECO:0000269|PubMed:6424111, ECO:0000269|PubMed:8421693}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Type 1 diabetes mellitus 2 (T1D2) [MIM:125852]: A multifactorial disorder of glucose homeostasis that is characterized by susceptibility to ketoacidosis in the absence of insulin therapy. Clinical features are polydipsia, polyphagia and polyuria which result from hyperglycemia-induced osmotic diuresis and secondary thirst. These derangements result in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. {ECO:0000269|PubMed:18192540}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Diabetes mellitus, permanent neonatal, 4 (PNDM4) [MIM:618858]: A form of permanent neonatal diabetes mellitus, a type of diabetes characterized by onset of persistent hyperglycemia within the first six months of life. Initial clinical manifestations include intrauterine growth retardation, hyperglycemia, glycosuria, osmotic polyuria, severe dehydration, and failure to thrive. PNDM4 transmission pattern is consistent with autosomal dominant or autosomal recessive inheritance. {ECO:0000269|PubMed:17855560, ECO:0000269|PubMed:18162506}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Maturity-onset diabetes of the young 10 (MODY10) [MIM:613370]: A form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease. {ECO:0000269|PubMed:18162506, ECO:0000269|PubMed:18192540, ECO:0000269|PubMed:20226046, ECO:0000269|PubMed:25423173}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
uniprot
proteins
mass_dalton
11981
uniprot
proteins
protein_family
Insulin family
uniprot
proteins
pubmed
12952878
uniprot
proteins
pubmed
1433291
uniprot
proteins
pubmed
14426955
uniprot
proteins
pubmed
15070567
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1601997
uniprot
proteins
pubmed
1646635
uniprot
proteins
pubmed
17855560
uniprot
proteins
pubmed
18162506
uniprot
proteins
pubmed
18192540
uniprot
proteins
pubmed
20226046
uniprot
proteins
pubmed
2036420
uniprot
proteins
pubmed
2196279
uniprot
proteins
pubmed
2271664
uniprot
proteins
pubmed
25423173
uniprot
proteins
pubmed
3470784
uniprot
proteins
pubmed
3537011
uniprot
proteins
pubmed
36309486
uniprot
proteins
pubmed
4019786
uniprot
proteins
pubmed
4443293
uniprot
proteins
pubmed
4698553
uniprot
proteins
pubmed
4698555
uniprot
proteins
pubmed
4803504
uniprot
proteins
pubmed
503234
uniprot
proteins
pubmed
5101771
uniprot
proteins
pubmed
5560404
uniprot
proteins
pubmed
6243748
uniprot
proteins
pubmed
6248962
uniprot
proteins
pubmed
6312455
uniprot
proteins
pubmed
6424111
uniprot
proteins
pubmed
6927840
uniprot
proteins
pubmed
8358440
uniprot
proteins
pubmed
8421693
uniprot
proteins
pubmed
9235985
uniprot
proteins
sequence_length
110
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:36309486}.
uniprot
proteins