Glud1
entrez
14661
canonical
uniprot
P26443
canonical
ensembl
ENSMUSG00000021794
resolver
ensp
ENSMUSP00000022322
resolver
enst
ENSMUST00000022322
resolver
genesymbol
Glud1
resolver
genesymbol_syn
Glud
resolver
uniprot
Q3TSQ7
resolver
uniprot
Q8C273
resolver
uniprot_entry
DHE3_MOUSE
resolver
uniprot_entry
Q3TSQ7_MOUSE
resolver
uniprot_sec
Q8C273
resolver
activity_regulation
ACTIVITY REGULATION: Subject to allosteric regulation. Activated by ADP. Inhibited by GTP and ATP. ADP can occupy the NADH binding site and activate the enzyme. Inhibited by SIRT4 (By similarity). Inhibited by HADH (PubMed:20670938). {ECO:0000250|UniProtKB:P00367, ECO:0000269|PubMed:20670938}.
uniprot
proteins
amino_acid_sequence
MYRRLGEALLLSRAGPAALGSAAADSAALLGWARGQPSAAPQPGLTPVARRHYSEAAADREDDPNFFKMVEGFFDRGASIVEDKLVEDLKTRESEEQKRNRVRGILRIIKPCNHVLSLSFPIRRDDGSWEVIEGYRAQHSQHRTPCKGGIRYSTDVSVDEVKALASLMTYKCAVVDVPFGGAKAGVKINPKNYTDNELEKITRRFTMELAKKGFIGPGIDVPAPDMSTGEREMSWIADTYASTIGHYDINAHACVTGKPISQGGIHGRISATGRGVFHGIENFINEASYMSILGMTPGFGDKTFVVQGFGNVGLHSMRYLHRFGAKCVGVGESDGSIWNPDGIDPKELEDFKLQHGSILGFPKAKVYEGSILEADCDILIPAASEKQLTKSNAPRVKAKIIAEGANGPTTPEADKIFLERNIMVIPDLYLNAGGVTVSYFEWLKNLNHVSYGRLTFKYERDSNYHLLMSVQESLERKFGKHGGTIPVVPTAEFQDRISGASEKDIVHSGLAYTMERSARQIMRTAMKYNLGLDLRTAAYVNAIEKVFKVYNEAGVTFT
uniprot
proteins
ec_number
1.4.1.3
uniprot
proteins
function
FUNCTION: Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate (PubMed:20670938). Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (By similarity). Plays a role in insulin homeostasis (PubMed:16959573). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity). {ECO:0000250|UniProtKB:P00367, ECO:0000250|UniProtKB:P10860, ECO:0000269|PubMed:16959573, ECO:0000269|PubMed:20670938, ECO:0000269|PubMed:23663782}.
uniprot
proteins
mass_dalton
61337
uniprot
proteins
post_translational_modification
PTM: Acetylation of Lys-84 is observed in liver mitochondria from fasted mice but not from fed mice.; PTM: ADP-ribosylated by SIRT4, leading to inactivate glutamate dehydrogenase activity (PubMed:16959573). Stoichiometry shows that ADP-ribosylation occurs in one subunit per catalytically active homohexamer (By similarity). {ECO:0000250|UniProtKB:P00367, ECO:0000269|PubMed:16959573}.
uniprot
proteins
protein_family
Glu/Leu/Phe/Val dehydrogenases family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16959573
uniprot
proteins
pubmed
1711373
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
20670938
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23576753
uniprot
proteins
pubmed
23663782
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
558
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:P00367}. Endoplasmic reticulum {ECO:0000250|UniProtKB:P00367}. Note=Mostly translocates into the mitochondria, only a small amount of the protein localizes to the endoplasmic reticulum. {ECO:0000250|UniProtKB:P00367}.
uniprot
proteins