HIP2
entrez
3093
canonical
uniprot
P61086
canonical
ensembl
ENSG00000078140
resolver
ensp
ENSP00000261427
resolver
ensp
ENSP00000390483
resolver
ensp
ENSP00000421203
resolver
ensp
ENSP00000425301
resolver
ensp
ENSP00000524035
resolver
genesymbol
HIP2
resolver
genesymbol
UBE2K
resolver
genesymbol_syn
HIP2
resolver
genesymbol_syn
LIG
resolver
hgnc
HGNC:4914
resolver
uniprot
A6NJC1
resolver
uniprot
A8K5Y9
resolver
uniprot
B2RDF8
resolver
uniprot
B3KSH4
resolver
uniprot
B4DIZ2
resolver
uniprot
C9JGP1
resolver
uniprot
O54806
resolver
uniprot
P27924
resolver
uniprot
Q16721
resolver
uniprot
Q9CVV9
resolver
uniprot
Q9Y2D3
resolver
uniprot_entry
B3KSH4_HUMAN
resolver
uniprot_entry
B4DIZ2_HUMAN
resolver
uniprot_entry
UBE2K_HUMAN
resolver
uniprot_sec
A6NJC1
resolver
uniprot_sec
A8K5Y9
resolver
uniprot_sec
B2RDF8
resolver
uniprot_sec
C9JGP1
resolver
uniprot_sec
O54806
resolver
uniprot_sec
P27924
resolver
uniprot_sec
Q16721
resolver
uniprot_sec
Q9CVV9
resolver
uniprot_sec
Q9Y2D3
resolver
amino_acid_sequence
MANIAVQRIKREFKEVLKSEETSKNQIKVDLVDENFTELRGEIAGPPDTPYEGGRYQLEIKIPETYPFNPPKVRFITKIWHPNISSVTGAICLDILKDQWAAAMTLRTVLLSLQALLAAAEPDDPQDAVVANQYKQNPEMFKQTARLWAHVYAGAPVSSPEYTKKIENLCAMGFDRNAVIVALSSKSWDVETATELLLSN
uniprot
proteins
ec_number
2.3.2.23
uniprot
proteins
function
FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1. {ECO:0000269|PubMed:10634809, ECO:0000269|PubMed:10675012, ECO:0000269|PubMed:16714285, ECO:0000269|PubMed:16868077, ECO:0000269|PubMed:17873885, ECO:0000269|PubMed:19906396, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:8702625}.
uniprot
proteins
mass_dalton
22407
uniprot
proteins
mutagenesis
MUTAGEN 94; /note="D->E: Decreased lysine reactivity and impaired formation of free polyubiquitin chains."; /evidence="ECO:0000269|PubMed:21532592
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000255|PROSITE-ProRule:PRU00388}.
uniprot
proteins
post_translational_modification
PTM: Sumoylation at Lys-14 impairs catalytic activity. {ECO:0000250|UniProtKB:P61085}.
uniprot
proteins
protein_family
Ubiquitin-conjugating enzyme family
uniprot
proteins
pubmed
10634809
uniprot
proteins
pubmed
10675012
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16714285
uniprot
proteins
pubmed
16868077
uniprot
proteins
pubmed
17873885
uniprot
proteins
pubmed
19407372
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19906396
uniprot
proteins
pubmed
20061386
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21532592
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
8702625
uniprot
proteins
sequence_length
200
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P61085}.
uniprot
proteins