Ezh1
entrez
14055
canonical
uniprot
P70351
canonical
ensembl
ENSMUSG00000006920
resolver
ensp
ENSMUSP00000097984
resolver
ensp
ENSMUSP00000102906
resolver
ensp
ENSMUSP00000259201
resolver
ensp
ENSMUSP00000259203
resolver
ensp
ENSMUSP00000259205
resolver
ensp
ENSMUSP00000259211
resolver
ensp
ENSMUSP00000259225
resolver
ensp
ENSMUSP00000259238
resolver
enst
ENSMUST00000107285
resolver
genesymbol
Ezh1
resolver
genesymbol_syn
Enx2
resolver
uniprot
A0A0R4J1C0
resolver
uniprot
A2A4K5
resolver
uniprot
Q3TPR1
resolver
uniprot
Q3U3V5
resolver
uniprot
Q3UU02
resolver
uniprot
Q8BR85
resolver
uniprot
Q922L1
resolver
uniprot
Q9R089
resolver
uniprot_entry
A0A0R4J1C0_MOUSE
resolver
uniprot_entry
EZH1_MOUSE
resolver
uniprot_sec
A2A4K5
resolver
uniprot_sec
Q3TPR1
resolver
uniprot_sec
Q3U3V5
resolver
uniprot_sec
Q3UU02
resolver
uniprot_sec
Q8BR85
resolver
uniprot_sec
Q922L1
resolver
uniprot_sec
Q9R089
resolver
amino_acid_sequence
MDIASPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEWKKLRVQPVQPMKPVSGHPFLKKCTIESIFPGFDSQDMLMRSLNTVALVPIMYSWSPLQQNFMVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELVDALNQYSDEEEDGHNDPSDGKQDDSKEDLPVTRKRKRHAIEGNKKSSKKQFPNDMIFSAIASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAMLHNPRSKCSGRRRRRHPVVSASCSNASASAMAETKEGDSDRDTGNDWASSSSEANSRCQTPTKQKASPAPAQLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKESLILKLPTDELMNPAQKKKRKHRLWAAHCRKIQLKKDNNSTQVYNYQPCDHPDRPCDSTCPCIMTQNFCEKFCQCSPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVVSCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEELFFDYRYSQADALKYVGIERETDVF
uniprot
proteins
ec_number
2.1.1.356
uniprot
proteins
function
FUNCTION: Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. {ECO:0000269|PubMed:19026780}.
uniprot
proteins
mass_dalton
85188
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
EZ subfamily
uniprot
proteins
protein_family
Histone-lysine methyltransferase family
uniprot
proteins
pubmed
10051331
uniprot
proteins
pubmed
11471062
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19026780
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20144788
uniprot
proteins
pubmed
31451685
uniprot
proteins
pubmed
9214638
uniprot
proteins
pubmed
9473645
uniprot
proteins
sequence_length
747
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Colocalizes with trimethylated 'Lys-27' of histone H3. {ECO:0000250}.
uniprot
proteins