NET1
entrez
10276
canonical
uniprot
Q7Z628
canonical
ensembl
ENSG00000173848
resolver
ensp
ENSP00000347134
resolver
ensp
ENSP00000369717
resolver
genesymbol
NET1
resolver
genesymbol_syn
ARHGEF8
resolver
hgnc
HGNC:14592
resolver
uniprot
Q12773
resolver
uniprot
Q5SQI5
resolver
uniprot
Q5SQI7
resolver
uniprot
Q96D82
resolver
uniprot
Q99903
resolver
uniprot
Q9UEN6
resolver
uniprot_entry
ARHG8_HUMAN
resolver
uniprot_entry
Q5SQI5_HUMAN
resolver
uniprot_entry
Q5SQI7_HUMAN
resolver
uniprot_sec
Q12773
resolver
uniprot_sec
Q96D82
resolver
uniprot_sec
Q99903
resolver
uniprot_sec
Q9UEN6
resolver
amino_acid_sequence
MEPELAAQKQPRPRRRSRRASGLSTEGATGPSADTSGSELDGRCSLRRGSSFTFLTPGPNWDFTLKRKRREKDDDVVSLSSLDLKEPSNKRVRPLARVTSLANLISPVRNGAVRRFGQTIQSFTLRGDHRSPASAQKFSSRSTVPTPAKRRSSALWSEMLDITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFGDLDSYIPLHEDLLTRIGEATKPDGTVEQIGHILVSWLPRLNAYRGYCSNQLAAKALLDQKKQDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDVQLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQRDPRIEASKVLLCHGELRSKSGHKLYIFLFQDILVLTRPVTRNERHSYQVYRQPIPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQQWFNCIRAAIAPFQSAGSPPELQGLPELHEECEGNHPSARKLTAQRRASTVSSVTQVEVDENAYRCGSGMQMAEDSKSLKTHQTQPGIRRARDKALSGGKRKETLV
uniprot
proteins
function
FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) for RhoA GTPase. May be involved in activation of the SAPK/JNK pathway Stimulates genotoxic stress-induced RHOB activity in breast cancer cells leading to their cell death. {ECO:0000269|PubMed:21373644}.
uniprot
proteins
mass_dalton
67740
uniprot
proteins
pubmed
11278519
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21373644
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
8649828
uniprot
proteins
sequence_length
596
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
uniprot
proteins