Nfe2
entrez
366998
canonical
uniprot
Q6AYT2
canonical
ensembl
ENSRNOG00000036837
resolver
ensembl
ENSRNOG00055029327
resolver
ensembl
ENSRNOG00060016347
resolver
ensembl
ENSRNOG00065023495
resolver
ensp
ENSRNOP00000052156
resolver
ensp
ENSRNOP00055041893
resolver
ensp
ENSRNOP00060022555
resolver
ensp
ENSRNOP00065032694
resolver
enst
ENSRNOT00000055281
resolver
enst
ENSRNOT00055050849
resolver
enst
ENSRNOT00060028033
resolver
enst
ENSRNOT00065040190
resolver
genesymbol
Nfe2
resolver
uniprot_entry
NFE2_RAT
resolver
amino_acid_sequence
MPPCPPQPNRNRLPQLPTGELGEMELTWQEIMSITELQGLNVPSEPSFEPQAPTPYPGPLPPPTYCPCSIHPDAGFTLPPPPYELPASTPHAPDLPYSYGNIAIPVSKPLTLSGLLNEPLPDPLALLDIGLPVGQPKPQEDPESDSGLSLNYSDAESLELEGTEAGRRRSEYVDMYPVEYPYSLMPNSLAHPNYTLPPTETPLVLESSSGPVRAKPAVRGEAGSRDERRALAMKIPFPTDKIVNLPVDDFNELLAQYPLTESQLALVRDIRRRGKNKVAAQNCRKRKLETIVQLERELERLGSERERLLRARGEADRTLEVMRQQLTELYHDIFQHLRDESGNSYSPEEYVLQQAADGAIFLVPRGTKMEATD
uniprot
proteins
function
FUNCTION: Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
41496
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine residues. In undifferentiated erythrocytes, phosphorylated by MAPK8 which then leads to ubiquitination and protein degradation. {ECO:0000250}.; PTM: Sumoylated. Sumoylation is required for translocation to nuclear bodies PODs, anchoring to the gene loci, and transactivation of the beta-globin gene. {ECO:0000250}.; PTM: Ubiquitinated mainly by 'Lys63'-linked ubiquitin. Polyubiquitination with 'Lys63'-linked ubiquitin by ITCH retains NFE2 in the cytoplasm preventing its transactivation activity. In undifferentiated erythrocyte, ubiquitinated after MAPK8-mediatd phosphorylation leading to protein degradation. {ECO:0000250}.
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
protein_family
CNC subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, PML body {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=The sumoylated form locates to the nuclear bodies PML oncogenic domains (PODs). Translocated to the cytoplasm through interaction with ITCH. {ECO:0000250}.
uniprot
proteins