Cttn
entrez
13043
canonical
uniprot
Q60598
canonical
ensembl
ENSMUSG00000031078
resolver
ensp
ENSMUSP00000033407
resolver
ensp
ENSMUSP00000099368
resolver
ensp
ENSMUSP00000209590
resolver
enst
ENSMUST00000033407
resolver
enst
ENSMUST00000103079
resolver
genesymbol
Cttn
resolver
genesymbol_syn
Ems1
resolver
uniprot
F8WGY7
resolver
uniprot
Q3UGC2
resolver
uniprot
Q8BNA5
resolver
uniprot
Q921L6
resolver
uniprot_entry
F8WGY7_MOUSE
resolver
uniprot_entry
Q8BNA5_MOUSE
resolver
uniprot_entry
Q921L6_MOUSE
resolver
uniprot_entry
SRC8_MOUSE
resolver
uniprot_sec
Q3UGC2
resolver
amino_acid_sequence
MWKASAGHAVSITQDDGGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRENVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDRSAVGHEYQSKLSKHCSQVDSVRGFGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQGKTEKHESQKDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQTDRQDKCALGWDHQEKLQLHESQKDYKTGFGGKFGVQSERQDSSAVGFDYKERLAKHESQQDYAKGFGGKYGVQKDRMDKNASTFEEVVQVPSAYQKTVPIEAVTSKTSNIRANFENLAKEREQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKKQTPPASPSPQPIEDRPPSSPIYEDAAPFKAEPSYRGSEPEPEYSIEAAGIPEAGSQQGLTYTSEPVYETTEAPGHYQAEDDTYDGYESDLGITAIALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVELRQ
uniprot
proteins
function
FUNCTION: Contributes to the organization of the actin cytoskeleton and cell shape (PubMed:17403031). Plays a role in the formation of lamellipodia and in cell migration (By similarity). Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Through its interaction with CTTNBP2, involved in the regulation of neuronal spine density (PubMed:22262902). Plays a role in focal adhesion assembly and turnover (By similarity). In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement (By similarity). Plays a role in intracellular protein transport and endocytosis, and in modulating the levels of potassium channels present at the cell membrane (PubMed:17959782). Plays a role in receptor-mediated endocytosis via clathrin-coated pits (By similarity). Required for stabilization of KCNH1 channels at the cell membrane (By similarity). {ECO:0000250|UniProtKB:Q14247, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:17403031, ECO:0000269|PubMed:17959782, ECO:0000269|PubMed:22262902}.
uniprot
proteins
mass_dalton
61250
uniprot
proteins
mutagenesis
MUTAGEN 22; /note="W->A: Abolishes cortactin-mediated endocytosis of KCNA2."; /evidence="ECO:0000269|PubMed:17959782"; MUTAGEN 421; /note="Y->F: No effect on interaction with KCNA2."; /evidence="ECO:0000269|PubMed:17959782"; MUTAGEN 466; /note="Y->F: No effect on interaction with KCNA2, but decreases KCNA2 levels at the cell membrane."; /evidence="ECO:0000269|PubMed:17959782"; MUTAGEN 482; /note="Y->F: No effect on interaction with KCNA2, but decreases KCNA2 levels at the cell membrane."; /evidence="ECO:0000269|PubMed:17959782
uniprot
proteins
post_translational_modification
PTM: Acetylated. {ECO:0000250|UniProtKB:Q14247}.; PTM: Phosphorylated by FER. Phosphorylated in response to FGR activation (PubMed:7693700). Phosphorylation by SRC promotes MYLK binding (By similarity). Phosphorylated on tyrosine residues in response to CHRM1 activation (By similarity). Phosphorylated by PTK2/FAK1 in response to cell adhesion (By similarity). Tyrosine phosphorylation in transformed cells may contribute to cellular growth regulation and transformation. Phosphorylated by PKN2 at both serine and threonine residues in a GTP-bound Rac1-dependent manner in hyaluronan-induced astrocytes and hence down-regulated CTTN ability to associate with filamentous actin. {ECO:0000250|UniProtKB:Q14247, ECO:0000250|UniProtKB:Q66HL2, ECO:0000269|PubMed:17403031, ECO:0000269|PubMed:22252131, ECO:0000269|PubMed:7693700}.
uniprot
proteins
pubmed
11433297
uniprot
proteins
pubmed
12913069
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17403031
uniprot
proteins
pubmed
17959782
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22252131
uniprot
proteins
pubmed
22262902
uniprot
proteins
pubmed
22297987
uniprot
proteins
pubmed
23015759
uniprot
proteins
pubmed
23296090
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
24574519
uniprot
proteins
pubmed
31600191
uniprot
proteins
pubmed
7516062
uniprot
proteins
pubmed
7693700
uniprot
proteins
sequence_length
546
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q14247}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q14247}. Cell projection, ruffle. Cell projection, dendrite. Cell projection {ECO:0000250|UniProtKB:Q66HL2}. Cell membrane {ECO:0000250|UniProtKB:Q66HL2}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cell projection, podosome {ECO:0000250|UniProtKB:Q01406}. Cell junction {ECO:0000250|UniProtKB:Q66HL2}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q66HL2}. Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:Q66HL2}. Cell projection, dendritic spine. Cytoplasm, cell cortex {ECO:0000250|UniProtKB:Q14247}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q01406}. Note=Colocalizes transiently with PTK2/FAK1 at focal adhesions (By similarity). Associated with membrane ruffles and lamellipodia. In the presence of CTTNBP2NL, colocalizes with stress fibers. In the presence of CTTNBP2, localizes at the cell cortex. In response to neuronal activation by glutamate, redistributes from dendritic spines to the dendritic shaft. Colocalizes with DNM2 at the basis of filopodia in hippocampus neuron growth zones (By similarity). {ECO:0000250|UniProtKB:Q14247, ECO:0000250|UniProtKB:Q66HL2}.
uniprot
proteins