Lnpk
entrez
69605
canonical
uniprot
Q7TQ95
canonical
ensembl
ENSMUSG00000009207
resolver
ensp
ENSMUSP00000066891
resolver
ensp
ENSMUSP00000099737
resolver
ensp
ENSMUSP00000107624
resolver
ensp
ENSMUSP00000363769
resolver
enst
ENSMUST00000064503
resolver
enst
ENSMUST00000102676
resolver
enst
ENSMUST00000111993
resolver
genesymbol
Lnpk
resolver
genesymbol_syn
Kiaa1715
resolver
genesymbol_syn
Lnp
resolver
genesymbol_syn
Lnpk1
resolver
genesymbol_syn
Uln
resolver
uniprot
A2ASL8
resolver
uniprot
A2ASL9
resolver
uniprot
Q69ZC5
resolver
uniprot
Q6PAQ1
resolver
uniprot
Q6PEN8
resolver
uniprot_entry
A2ASL8_MOUSE
resolver
uniprot_entry
LNP_MOUSE
resolver
uniprot_sec
A2ASL9
resolver
uniprot_sec
Q69ZC5
resolver
uniprot_sec
Q6PAQ1
resolver
uniprot_sec
Q6PEN8
resolver
amino_acid_sequence
MGGLFSRWRAKPSTVEVLENIDKEIQALEEFREKNQRLQKLWVGRLIIYSSILYLFTCLIVYLWYLPDEFTARLVMTLPFFAFPLIIWTLRTVLIFFFSKRTERNNEALDDLKSQKKKILEEVMEKETYKTAKLILERFDPDSKKAKEFEPPSAGAAVTAKPGQEIRQRTAAQRNLSPAPASSSQGPPPQGPVSPGPAKDASAPGGPPERTVAPALPRRLGSPATSVPGMGLHPPGPPLARPILPRERGALDRIVEYLVGDGPQNRYALICQQCFSHNGMALKEEFEYIAFRCAYCFFLNPARKTRPQAPRLPEFSFEKRQAVEGSSSTGPTLLESVPSAESQLIEDSLEEQDVLDNSTEQRDDKIPVTEQTSQVIEKTSGPEEPAENQEETENEETSTNEAKSPVLRADSVPNLEPSEESLVTK
uniprot
proteins
function
FUNCTION: Endoplasmic reticulum (ER)-shaping membrane protein that plays a role in determining ER morphology. Involved in the stabilization of nascent three-way ER tubular junctions within the ER network. May also play a role as a curvature-stabilizing protein within three-way ER tubular junction network. May be involved in limb and central nervous system development (PubMed:12732147). {ECO:0000250|UniProtKB:Q9C0E8, ECO:0000269|PubMed:12732147}.
uniprot
proteins
mass_dalton
47500
uniprot
proteins
post_translational_modification
PTM: Myristoylated; myristoylation is necessary for the endoplasmic reticulum (ER) three-way ER tubular junction formation, but is not required neither for membrane translocation, membrane topology formation, nor for the specific localization to ER membranes. {ECO:0000250|UniProtKB:Q9C0E8}.; PTM: Phosphorylated. Phosphorylation occurs at Ser-177, Ser-182, Ser-222, Ser-316 and Ser-380 during interphase. Phosphorylation occurs at Ser-114, Ser-153, Ser-194, Thr-211 and Ser-348 during mitosis; these phosphorylations reduce both its homodimerization and the ER three-way tubular junction formation. {ECO:0000250|UniProtKB:Q9C0E8}.; PTM: Subject to proteasomal degradation following phosphorylation during mitosis. {ECO:0000250|UniProtKB:Q9C0E8}.
uniprot
proteins
protein_family
Lunapark family
uniprot
proteins
pubmed
12732147
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
425
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9C0E8}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9C0E8}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9C0E8}. Note=Localizes at endoplasmic reticulum (ER) three-way tubular junctions, which represent crossing-points at which the tubules build a polygonal network. {ECO:0000250|UniProtKB:Q9C0E8}.
uniprot
proteins
transmembrane_region
TRANSMEM 46..66; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 78..98; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins