TAS2R4
entrez
50832
canonical
uniprot
Q9NYW5
canonical
ensembl
ENSG00000127364
resolver
ensp
ENSP00000247881
resolver
enst
ENST00000247881
resolver
genesymbol
TAS2R4
resolver
hgnc
HGNC:14911
resolver
uniprot
Q645W5
resolver
uniprot
Q75MV8
resolver
uniprot_entry
TA2R4_HUMAN
resolver
uniprot_sec
Q645W5
resolver
uniprot_sec
Q75MV8
resolver
amino_acid_sequence
MLRLFYFSAIIASVILNFVGIIMNLFITVVNCKTWVKSHRISSSDRILFSLGITRFLMLGLFLVNTIYFVSSNTERSVYLSAFFVLCFMFLDSSSVWFVTLLNILYCVKITNFQHSVFLLLKRNISPKIPRLLLACVLISAFTTCLYITLSQASPFPELVTTRNNTSFNISEGILSLVVSLVLSSSLQFIINVTSASLLIHSLRRHIQKMQKNATGFWNPQTEAHVGAMKLMVYFLILYIPYSVATLVQYLPFYAGMDMGTKSICLIFATLYSPGHSVLIIITHPKLKTTAKKILCFKK
uniprot
proteins
function
FUNCTION: Gustducin-coupled receptor for denatonium and N(6)-propyl-2-thiouracil implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5. In airway epithelial cells, binding of denatonium increases the intracellular calcium ion concentration and stimulates ciliary beat frequency. {ECO:0000269|PubMed:19628819}.
uniprot
proteins
mass_dalton
33841
uniprot
proteins
protein_family
G protein-coupled receptor T2R family
uniprot
proteins
pubmed
10761934
uniprot
proteins
pubmed
10761935
uniprot
proteins
pubmed
11696554
uniprot
proteins
pubmed
12139982
uniprot
proteins
pubmed
12581520
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15496549
uniprot
proteins
pubmed
19628819
uniprot
proteins
sequence_length
299
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:19628819}; Multi-pass membrane protein {ECO:0000269|PubMed:19628819}. Cell projection, cilium membrane {ECO:0000269|PubMed:19628819}. Note=In airway epithelial cells, localizes to motile cilia.
uniprot
proteins
transmembrane_region
TRANSMEM 10..30; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 47..67; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 82..102; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 132..152; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 173..193; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 231..251; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 263..283; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins