SLC25A6
entrez
293
canonical
uniprot
P12236
canonical
ensembl
ENSG00000169100
resolver
ensembl
ENSG00000292334
resolver
ensp
ENSP00000370808
resolver
ensp
ENSP00000518609
resolver
ensp
ENSP00000542001
resolver
ensp
ENSP00000606621
resolver
ensp
ENSP00000636953
resolver
ensp
ENSP00000636954
resolver
ensp
ENSP00000642817
resolver
ensp
ENSP00000642862
resolver
ensp
ENSP00000642896
resolver
ensp
ENSP00000642897
resolver
enst
ENST00000381401
resolver
enst
ENST00000711212
resolver
enst
ENST00000871942
resolver
enst
ENST00000936562
resolver
enst
ENST00000966894
resolver
enst
ENST00000966895
resolver
enst
ENST00000972955
resolver
enst
ENST00000973000
resolver
enst
ENST00000973034
resolver
enst
ENST00000973035
resolver
genesymbol
SLC25A6
resolver
genesymbol_syn
AAC3
resolver
genesymbol_syn
ANT3
resolver
hgnc
HGNC:10992
resolver
uniprot
Q6I9V5
resolver
uniprot
Q96C49
resolver
uniprot_entry
ADT3_HUMAN
resolver
uniprot_entry
Q6I9V5_HUMAN
resolver
uniprot_sec
Q96C49
resolver
activity_regulation
ACTIVITY REGULATION: The matrix-open state (m-state) is inhibited by the membrane-permeable bongkrekic acid (BKA). The cytoplasmic-open state (c-state) is inhibited by the membrane-impermeable toxic inhibitor carboxyatractyloside (CATR) (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity (By similarity). {ECO:0000250|UniProtKB:G2QNH0, ECO:0000250|UniProtKB:P48962}.
uniprot
proteins
amino_acid_sequence
MTEQAISFAKDFLAGGIAAAISKTAVAPIERVKLLLQVQHASKQIAADKQYKGIVDCIVRIPKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKHTQFWRYFAGNLASGGAAGATSLCFVYPLDFARTRLAADVGKSGTEREFRGLGDCLVKITKSDGIRGLYQGFSVSVQGIIIYRAAYFGVYDTAKGMLPDPKNTHIVVSWMIAQTVTAVAGVVSYPFDTVRRRMMMQSGRKGADIMYTGTVDCWRKIFRDEGGKAFFKGAWSNVLRGMGGAFVLVLYDELKKVI
uniprot
proteins
function
FUNCTION: ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity (PubMed:15033708). Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A6/ANT3 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death (PubMed:15033708). It is however unclear if SLC25A6/ANT3 constitutes a pore-forming component of mPTP or regulates it (By similarity). {ECO:0000250|UniProtKB:G2QNH0, ECO:0000250|UniProtKB:P48962, ECO:0000269|PubMed:15033708}.
uniprot
proteins
mass_dalton
32866
uniprot
proteins
post_translational_modification
PTM: Trimethylated by ANTKMT at Lys-52. {ECO:0000269|PubMed:31213526}.
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
14654843
uniprot
proteins
pubmed
15033708
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16120388
uniprot
proteins
pubmed
16201016
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
2541251
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27641616
uniprot
proteins
pubmed
2829183
uniprot
proteins
pubmed
31213526
uniprot
proteins
pubmed
31341297
uniprot
proteins
pubmed
8486369
uniprot
proteins
sequence_length
298
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250|UniProtKB:P02722}; Multi-pass membrane protein {ECO:0000255}. Membrane {ECO:0000269|PubMed:27641616}; Multi-pass membrane protein {ECO:0000255}. Note=The complex formed with ARL2BP, ARL2 and SLC25A6/ANT3 is expressed in mitochondria (By similarity). May localize to non-mitochondrial membranes (By similarity). {ECO:0000250|UniProtKB:P12235}.
uniprot
proteins
transmembrane_region
TRANSMEM 8..37; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P02722"; TRANSMEM 75..99; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P02722"; TRANSMEM 110..130; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P02722"; TRANSMEM 179..199; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P02722"; TRANSMEM 211..231; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P02722"; TRANSMEM 274..291; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P02722
uniprot
proteins