Q61738
uniprot
Q61738
canonical
amino_acid_sequence
MARIPRCDFLRPPGIYYLITSLLAGLFLPPAIAFNLDVMGAIRKEGEPGSLFGFSVALHRQLQPRPQSWLLVGAPQALALPGQQANRTGGLFACPLSLEETDCYRVDIDRGANVQKESKENQWLGVSVRSQGAGGKIVTCAHRYESRQRVDQALETRDVIGRCFVLSQDLAIRDELDGGEWKFCEGRPQGHEQFGFCQQGTAATFSPDSHYLVFGAPGTYNWKGTARVELCAQGSPDLAHLDDGPYEAGGEKEQDPRLIPVPANSYLGLLFVTNIDSSDPDQLVYKTLDPADRLTGPAGDLTLNSYLGFSIDSGKGLMRSEELSFVAGAPRANHKGAVVILRKDSATRLIPEVVLSGERLTSGFGYSLAVTDLNNDGWADLIVGAPYFFERQEELGGAVYVYMNQGGHWADISPLRICGSPDSMFGISLAVLGDLNQDGFPDIAVGAPFDGDGKVFIYHGSSLGVVVKPSQVLEGEAVGIKSFGYSLSGGLDVDGNHYPDLLVGSLADTAALFRARPVLHVSQEIFIDPRAIDLEQPNCADGRLVCVDIKICFSYVAVPSSYSPSVALDYMLDGDTDRRLRGQVPRVTFLSRGLDDLRHQSSGTVWLKHQHDRVCGDTVFQLQENVKDKLRAIVVTLSYGLRTPPLGRQAPGQELPTVAPILNAHQPSTQRTEIHFLKQGCGQDKICQSNLQLERYQFCSRISDTEFQALPMDLDGRTALFALSGQPFIGLELTVTNLPSDPSRPQADGDDAHEAQLLVTLPASLRYSGVRALDSVEKPLCLSNDSASHVECELGNPMKRGAQVTFYLILSTSGITIETTELEVKLLLATISEQELDPVSVRAHVFIELPLSISGVATPQQLFFSGEVKGESAMRSERELGRKVKYEVTVSNQGQSLNTLGSANLNIMWPHEIANGKWLLYPMRVELEGGQGPGKRGICSPRPNILQLDVDSRDRRRRELGQPEPQEPPEKVEPSTSWWPVSSAEKRNMTLDCPRTAKCVVFSCPLYSFDRAAVLHVWGRLWNSTFLEEYMAVKSLEVIVRANITVKSSIKNLLLRDASTVIPVMVYLDPMAVVVEGVPWWVILLGVLAGLLVLALLVLLLWKLGFFKRAKHPEATVPQYHAVKIPREDRQQFKEEKTGTIQRSNWGNSQWEGSDAHPILAADWHPELGPDGHPVPATA
uniprot
proteins
function
FUNCTION: Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. Involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Mice carrying a ITGA7 null allele are viable and fertile, but show progressive muscular dystrophy starting soon after birth, but with a distinct variability in different muscle types. Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells. Acts as a Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). {ECO:0000250, ECO:0000269|PubMed:9354797}.
uniprot
proteins
mass_dalton
129329
uniprot
proteins
post_translational_modification
PTM: ADP-ribosylated on at least two sites of the extracellular domain in skeletal myotubes (in vitro).; PTM: No proteolytic cleavage to produce the 70 kDa form is seen due to the presence of a Gly instead of an arginine residue at position 647.
uniprot
proteins
protein_family
Integrin alpha chain family
uniprot
proteins
pubmed
1839357
uniprot
proteins
pubmed
18940796
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7721841
uniprot
proteins
pubmed
8253814
uniprot
proteins
pubmed
8360188
uniprot
proteins
pubmed
8626012
uniprot
proteins
pubmed
8798472
uniprot
proteins
pubmed
9354797
uniprot
proteins
sequence_length
1179
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 1077..1102; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins