INPP5F
entrez
22876
canonical
uniprot
Q9Y2H2
canonical
ensembl
ENSG00000198825
resolver
ensp
ENSP00000489864
resolver
ensp
ENSP00000496955
resolver
ensp
ENSP00000497368
resolver
ensp
ENSP00000497527
resolver
ensp
ENSP00000497772
resolver
ensp
ENSP00000497846
resolver
ensp
ENSP00000565175
resolver
ensp
ENSP00000565176
resolver
ensp
ENSP00000565177
resolver
ensp
ENSP00000634626
resolver
ensp
ENSP00000712804
resolver
ensp
ENSP00000712805
resolver
ensp
ENSP00000780989
resolver
ensp
ENSP00000783816
resolver
enst
ENST00000647699
resolver
enst
ENST00000649251
resolver
enst
ENST00000649454
resolver
genesymbol
INPP5F
resolver
genesymbol_syn
KIAA0966
resolver
genesymbol_syn
SAC2
resolver
hgnc
HGNC:17054
resolver
uniprot
A0A3B3ISI3
resolver
uniprot
A0A3B3ITL0
resolver
uniprot
B3KRF1
resolver
uniprot
D3DRD1
resolver
uniprot
Q2T9J4
resolver
uniprot
Q5W135
resolver
uniprot
Q5W136
resolver
uniprot
Q6NVY2
resolver
uniprot
Q86U97
resolver
uniprot
Q9H3D9
resolver
uniprot
Q9NT51
resolver
uniprot_entry
A0A3B3ISI3_HUMAN
resolver
uniprot_entry
A0A3B3ITL0_HUMAN
resolver
uniprot_entry
SAC2_HUMAN
resolver
uniprot_sec
B3KRF1
resolver
uniprot_sec
D3DRD1
resolver
uniprot_sec
Q2T9J4
resolver
uniprot_sec
Q5W135
resolver
uniprot_sec
Q5W136
resolver
uniprot_sec
Q6NVY2
resolver
uniprot_sec
Q86U97
resolver
uniprot_sec
Q9H3D9
resolver
uniprot_sec
Q9NT51
resolver
amino_acid_sequence
MELFQAKDHYILQQGERALWCSRRDGGLQLRPATDLLLAWNPICLGLVEGVIGKIQLHSDLPWWLILIRQKALVGKLPGDHEVCKVTKIAVLSLSEMEPQDLELELCKKHHFGINKPEKIIPSPDDSKFLLKTFTHIKSNVSAPNKKKVKESKEKEKLERRLLEELLKMFMDSESFYYSLTYDLTNSVQRQSTGERDGRPLWQKVDDRFFWNKYMIQDLTEIGTPDVDFWIIPMIQGFVQIEELVVNYTESSDDEKSSPETPPQESTCVDDIHPRFLVALISRRSRHRAGMRYKRRGVDKNGNVANYVETEQLIHVHNHTLSFVQTRGSVPVFWSQVGYRYNPRPRLDRSEKETVAYFCAHFEEQLNIYKKQVIINLVDQAGREKIIGDAYLKQVLLFNNSHLTYVSFDFHEHCRGMKFENVQTLTDAIYDIILDMKWCWVDEAGVICKQEGIFRVNCMDCLDRTNVVQAAIARVVMEQQLKKLGVMPPEQPLPVKCNRIYQIMWANNGDSISRQYAGTAALKGDFTRTGERKLAGVMKDGVNSANRYYLNRFKDAYRQAVIDLMQGIPVTEDLYSIFTKEKEHEALHKENQRSHQELISQLLQSYMKLLLPDDEKFHGGWALIDCDPSLIDATHRDVDVLLLLSNSAYYVAYYDDEVDKVNQYQRLSLENLEKIEIGPEPTLFGKPKFSCMRLHYRYKEASGYFHTLRAVMRNPEEDGKDTLQCIAEMLQITKQAMGSDLPIIEKKLERKSSKPHEDIIGIRSQNQGSLAQGKNFLMSKFSSLNQKVKQTKSNVNIGNLRKLGNFTKPEMKVNFLKPNLKVNLWKSDSSLETMENTGVMDKVQAESDGDMSSDNDSYHSDEFLTNSKSDEDRQLANSLESVGPIDYVLPSCGIIASAPRLGSRSQSLSSTDSSVHAPSEITVAHGSGLGKGQESPLKKSPSAGDVHILTGFAKPMDIYCHRFVQDAQNKVTHLSETRSVSQQASQERNQMTNQVSNETQSESTEQTPSRPSQLDVSLSATGPQFLSVEPAHSVASQKTPTSASSMLELETGLHVTPSPSESSSSRAVSPFAKIRSSMVQVASITQAGLTHGINFAVSKVQKSPPEPEIINQVQQNELKKMFIQCQTRIIQI
uniprot
proteins
ec_number
3.1.3.-
uniprot
proteins
function
FUNCTION: Phosphoinositide phosphatase which catalyzes the hydrolysis of phosphatidylinositol 4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PtdIns(4)P). May be functionally linked to OCRL, which converts phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) to PtdIns, for a sequential dephosphorylation of (PtdIns(4,5)P2) at the 5 and 4 position of inositol, thus playing an important role in the endocytic recycling (PubMed:25869668, PubMed:25869669). Regulator of TF:TFRC and integrins recycling pathway, is also involved in cell migration mechanisms (PubMed:25869669). Modulates AKT/GSK3B pathway by decreasing AKT and GSK3B phosphorylation (PubMed:17322895). Negatively regulates STAT3 signaling pathway through inhibition of STAT3 phosphorylation and translocation to the nucleus (PubMed:25476455). Functionally important modulator of cardiac myocyte size and of the cardiac response to stress (By similarity). May play a role as negative regulator of axon regeneration after central nervous system injuries (By similarity). May be involved in insulin granule docking at the plasma membrane of pancreatic cells, an essential step for insulin secretion (PubMed:31533953). {ECO:0000250|UniProtKB:Q8CDA1, ECO:0000269|PubMed:17322895, ECO:0000269|PubMed:25476455, ECO:0000269|PubMed:25869668, ECO:0000269|PubMed:25869669, ECO:0000269|PubMed:31533953}.
uniprot
proteins
mass_dalton
128407
uniprot
proteins
mutagenesis
MUTAGEN 458; /note="C->S: Loss of inositol 4-phosphatase activity. Alters TFRC distribution and delays TF recycling."; /evidence="ECO:0000269|PubMed:25869669
uniprot
proteins
pubmed
10231032
uniprot
proteins
pubmed
11274189
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17322895
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25476455
uniprot
proteins
pubmed
25869668
uniprot
proteins
pubmed
25869669
uniprot
proteins
pubmed
26203138
uniprot
proteins
pubmed
31533953
uniprot
proteins
sequence_length
1132
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane, clathrin-coated pit {ECO:0000269|PubMed:25869669}. Early endosome {ECO:0000269|PubMed:25869669}. Recycling endosome {ECO:0000269|PubMed:25869669}. Note=Also found on macropinosomes. {ECO:0000250|UniProtKB:Q8CDA1}.
uniprot
proteins