Mphosph8
entrez
75339
canonical
uniprot
Q3TYA6
canonical
ensembl
ENSMUSG00000079184
resolver
ensp
ENSMUSP00000112170
resolver
ensp
ENSMUSP00000294442
resolver
ensp
ENSMUSP00000341528
resolver
enst
ENSMUST00000116468
resolver
genesymbol
Mphosph8
resolver
genesymbol_syn
Mpp8
resolver
uniprot
A6H600
resolver
uniprot
Q3TWY7
resolver
uniprot_entry
MPP8_MOUSE
resolver
uniprot_sec
A6H600
resolver
uniprot_sec
Q3TWY7
resolver
amino_acid_sequence
MAAAAEEGMSAAALVMSVPDSIGRSPESEGVGAGDEEKDAATKGTVAVGDSEEDGEDVFEVERILDMKCEGGKNLYKVRWKGYTSEDDTWEPEVHLEDCKEVLLEFRKKLAENKAKAVRKDIQRLSLNNDIFEADSDSDQQSDTKEDISPRKKKKKIKCKEETSPEDLRKKRTKMGKLKDKFKTELESTSEIIGFDVKTKKRIWEVKEELKDSKKPKKDEIKETKELKKANKRAEVRDLKIKIREDVKENRKTKKERYIESPLESESPNDSLILEDDSEDFISDNREENQNVRSVRDKTAQETVQEGIFEKHLDDLISIEEDAGTRVRRKKTKPRKFEEPKEIKKLESTNAFLERRAIPKKQRNQDKGISNLELNKLPSPVFAQTLKSSRLSGEEKSLKSPDLAEEEKEKKNEPKGKYQKRYDLDKEEKARKEPKVLKSFKEIRNAFDLFKKTTEEKNDVLENNSKREEISLDSKIMNDNKTKDKCSLKEKRNTRDETDTWAYIAAEGDQEVSDSVCQTDETSDGRQPVLSLGMDLQLEWMKLEDFQKHLDGEDEPFITTNRIPNNLLRDAVKNGDYIAVKVALNSNEEYNLDQEDSTGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALYFAKQCNNVLVYELLKSHLETLSRVAEETIRDYFESRLALLEPVFPIACHRLCEGPDFSTDFNYMPPQNMPEGSGVLLFIFHANFLGKDVIARLCGPCSVQAVVLNDKFQLPVFLDSHFVYSFSPVAGPNKLFIRLTEAPFAKVKLLIGAYRVQLQ
uniprot
proteins
function
FUNCTION: Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression (By similarity). As part of the HUSH complex, promotes epigenetic repression of mobile genetic elements, such as retroviruses and transposable elements: the HUSH complex mainly represses LINE-1 (L1) retrotransposons that are still capable of transposition (By similarity). Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression (By similarity). MPHOSPH8 mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2, a chromatin remodeler that compacts chromatin (By similarity). The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed (By similarity). As part of the HUSH2 complex, promotes epigenetic repression of interferon-stimulated genes (By similarity). Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene (By similarity). Mediates silencing of E-cadherin (CDH1) and protocadherin genes in the nervous system (PubMed:36332029). {ECO:0000250|UniProtKB:Q99549, ECO:0000269|PubMed:36332029}.
uniprot
proteins
mass_dalton
97467
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in M (mitotic) phase. Phosphorylation by CDK1 promotes dissociation from chromatin. {ECO:0000250|UniProtKB:Q99549}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23416073
uniprot
proteins
pubmed
31112734
uniprot
proteins
pubmed
34272044
uniprot
proteins
pubmed
36332029
uniprot
proteins
sequence_length
858
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:23416073}. Chromosome {ECO:0000269|PubMed:23416073}. Note=Detected on heterochromatin (PubMed:23416073). Dissociates from chromatin during interphase and early mitosis (PubMed:23416073). Detected on nucleosomes (By similarity). {ECO:0000250|UniProtKB:Q99549, ECO:0000269|PubMed:23416073}.
uniprot
proteins