MMP16
entrez
4325
canonical
uniprot
P51512
canonical
ensembl
ENSG00000156103
resolver
ensp
ENSP00000286614
resolver
genesymbol
MMP16
resolver
genesymbol_syn
C8orf57
resolver
genesymbol_syn
MMPX2
resolver
hgnc
HGNC:7162
resolver
uniprot
B2RAN7
resolver
uniprot
Q14824
resolver
uniprot
Q52H48
resolver
uniprot_entry
MMP16_HUMAN
resolver
uniprot_sec
B2RAN7
resolver
uniprot_sec
Q14824
resolver
uniprot_sec
Q52H48
resolver
activity_regulation
ACTIVITY REGULATION: TIMP-2 shows little inhibitory activity compared to TIMP-1. TIMP-1 seems to have less binding affinity than TIMP-2 for the short isoform.
uniprot
proteins
amino_acid_sequence
MILLTFSTGRRLDFVHHSGVFFLQTLLWILCATVCGTEQYFNVEVWLQKYGYLPPTDPRMSVLRSAETMQSALAAMQQFYGINMTGKVDRNTIDWMKKPRCGVPDQTRGSSKFHIRRKRYALTGQKWQHKHITYSIKNVTPKVGDPETRKAIRRAFDVWQNVTPLTFEEVPYSELENGKRDVDITIIFASGFHGDSSPFDGEGGFLAHAYFPGPGIGGDTHFDSDEPWTLGNPNHDGNDLFLVAVHELGHALGLEHSNDPTAIMAPFYQYMETDNFKLPNDDLQGIQKIYGPPDKIPPPTRPLPTVPPHRSIPPADPRKNDRPKPPRPPTGRPSYPGAKPNICDGNFNTLAILRREMFVFKDQWFWRVRNNRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFKDTTLQPGYPHDLITLGSGIPPHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGHSPPDDVDIVIKLDNTASTVKAIAIVIPCILALCLLVLVYTVFQFKRKGTPRHILYCKRSMQEWV
uniprot
proteins
ec_number
3.4.24.-
uniprot
proteins
function
FUNCTION: Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells. {ECO:0000269|PubMed:11278606}.
uniprot
proteins
mass_dalton
69521
uniprot
proteins
post_translational_modification
PTM: The precursor is cleaved by a furin endopeptidase. {ECO:0000250}.
uniprot
proteins
protein_family
Peptidase M10A family
uniprot
proteins
pubmed
11278606
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14741217
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
7559440
uniprot
proteins
pubmed
9092507
uniprot
proteins
pubmed
9396633
uniprot
proteins
sequence_length
607
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform Long]: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}; Extracellular side {ECO:0000305}. Note=Localized at the cell surface of melanoma cells.; SUBCELLULAR LOCATION: [Isoform Short]: Secreted, extracellular space, extracellular matrix. Cell surface. Note=Localized at the cell surface of melanoma cells.
uniprot
proteins
transmembrane_region
TRANSMEM 565..585; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins