Tmem9
entrez
66241
canonical
uniprot
Q9CR23
canonical
ensembl
ENSMUSG00000026411
resolver
ensp
ENSMUSP00000065409
resolver
ensp
ENSMUSP00000113416
resolver
ensp
ENSMUSP00000128185
resolver
enst
ENSMUST00000063719
resolver
enst
ENSMUST00000117950
resolver
enst
ENSMUST00000165125
resolver
genesymbol
Tmem9
resolver
uniprot
Q3U459
resolver
uniprot_entry
TMEM9_MOUSE
resolver
uniprot_sec
Q3U459
resolver
amino_acid_sequence
MKLLCLVAVVGCLLVPPAQANKSSEDIRCKCICPPYRNISGHIYNQNVSQKDCNCLHVVEPMPVPGHDVEAYCLLCECRYEERSTTTIKVIIVIYLSVVGALLLYMAFLMLVDPLIRKPDAYTEQLHNEEENEDARTMATAAASIGGPRANTVLERVEGAQQRWKLQVQEQRKTVFDRHKMLS
uniprot
proteins
function
FUNCTION: Transmembrane protein that binds to and facilitates the assembly of lysosomal proton-transporting V-type ATPase (v-ATPase), resulting in enhanced lysosomal acidification and trafficking (By similarity). By bringing the v-ATPase accessory protein ATP6AP2 and the v-ATPase subunit ATP6V0D1 together, allows v-ATPase complex formation and activation (By similarity). TMEM9-controlled vesicular acidification induces hyperactivation of Wnt/beta-catenin signaling, involved in development, tissue homeostasis and tissue regeneration, through lysosomal degradation of adenomatous polyposis coli/APC (PubMed:30374053, PubMed:32380568). In the liver, involved in hepatic regeneration (PubMed:32380568). {ECO:0000250|UniProtKB:Q9P0T7, ECO:0000269|PubMed:30374053, ECO:0000269|PubMed:32380568}.
uniprot
proteins
mass_dalton
20633
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:Q9P0T7}.
uniprot
proteins
protein_family
TMEM9 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
30374053
uniprot
proteins
pubmed
32380568
uniprot
proteins
sequence_length
183
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q9P0T7}; Single-pass type I membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000250|UniProtKB:Q9P0T7}; Single-pass type I membrane protein {ECO:0000255}. Endosome, multivesicular body membrane {ECO:0000250|UniProtKB:Q9P0T7}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 90..110; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins