Kmt5a
entrez
67956
canonical
uniprot
Q2YDW7
canonical
ensembl
ENSMUSG00000049327
resolver
ensp
ENSMUSP00000052953
resolver
ensp
ENSMUSP00000098275
resolver
ensp
ENSMUSP00000143207
resolver
enst
ENSMUST00000059580
resolver
enst
ENSMUST00000100709
resolver
enst
ENSMUST00000198451
resolver
genesymbol
Kmt5a
resolver
genesymbol_syn
Setd8
resolver
uniprot
A0A0G2JFK5
resolver
uniprot
D3YXI6
resolver
uniprot
E9QNB8
resolver
uniprot
Q8C0J9
resolver
uniprot
Q8C1L9
resolver
uniprot_entry
A0A0G2JFK5_MOUSE
resolver
uniprot_entry
D3YXI6_MOUSE
resolver
uniprot_entry
E9QNB8_MOUSE
resolver
uniprot_entry
KMT5A_MOUSE
resolver
uniprot_entry
Q8C1L9_MOUSE
resolver
uniprot_sec
Q8C0J9
resolver
amino_acid_sequence
MARGRKMCKPRAVEAAAAAVAATAPGPEMVEQRGPGRPRSDGENVFAGQSKIYAYMSPNKCSAMRSPLQEENSVAHHEVKCPGKPLAGIYRKREEKRNTGNVIRSAVKSDEQKSKDTRRGPLAPFPNQKSEAAEPPKTPPPSCDSTNVAVAKQALKKSLKGKQAPRKKSQGKTQQNRKLTDFYPVRRSSRKSKAELQSEERKKNELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFVVEYHGDLIEITDAKKREALYVQDPSTGCYMYYFQYLSKTYCVDATQETNRLGRLINHSKCGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKASIEAYPWLKH
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
ec_number
2.1.1.361
uniprot
proteins
function
FUNCTION: Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration. {ECO:0000250|UniProtKB:Q9NQR1}.
uniprot
proteins
mass_dalton
38845
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated and degraded by the DCX(DTL) complex. {ECO:0000305}.
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
Histone-lysine methyltransferase family
uniprot
proteins
protein_family
PR/SET subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23468428
uniprot
proteins
sequence_length
349
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9NQR1}. Chromosome {ECO:0000269|PubMed:23468428}. Note=Specifically localizes to mitotic chromosomes. Associates with silent chromatin on euchromatic arms. Not associated with constitutive heterochromatin (By similarity). Colocalized with SIRT2 at mitotic foci. Associates with chromosomes during mitosis; association is increased in a H(2)O(2)-induced oxidative stress-dependent manner. {ECO:0000250|UniProtKB:Q9NQR1, ECO:0000269|PubMed:23468428}.
uniprot
proteins