Ift57
entrez
73916
canonical
uniprot
Q8BXG3
canonical
ensembl
ENSMUSG00000032965
resolver
ensp
ENSMUSP00000046645
resolver
genesymbol
Ift57
resolver
genesymbol_syn
Hippi
resolver
uniprot
B2RQZ0
resolver
uniprot
Q924M2
resolver
uniprot
Q9CUS6
resolver
uniprot_entry
B2RQZ0_MOUSE
resolver
uniprot_entry
IFT57_MOUSE
resolver
uniprot_sec
Q924M2
resolver
uniprot_sec
Q9CUS6
resolver
amino_acid_sequence
MAAAAAVIPPSGLDDGVSRARGEGAGEAVVERGPGAAYHMFVVMEDLVEKLKLLRYEEELLRKSNLKPPSRHYFALPTNPGEQFYMFCTLAAWLINKTGRAFEQPQEYDDPNATISNILSELRSFGRTADFPPSKLKSGYGEQVCYVLDCLAEEALKYIGFTWKRPSYPVEELEEETVPEDDAELTLSKVDEEFVEEETDNEENFIDLNVLKAQTYRLDTNESAKQEDILESTTDAAEWSLEVERVLPQLKVTIRTDNKDWRIHVDQMHQHKSGIESALKETKGFLDKLHNEISRTLEKIGSREKYINNQLEHLVQEYRGAQAQLSEARERYQQGNGGVTERTRLLSEVTEELEKVKQEMEEKGSSMTDGTPLVKIKQSLTKLKQETVQMDIRIGVVEHTLLQSKLKEKCNMTRDMHAAVTPESAIGFY
uniprot
proteins
function
FUNCTION: Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway. Together with RAB23 and KIF17, it is required for the localization of specific G protein-coupled receptors, such as dopamime receptor DRD1, to primary cilia (By similarity). Has pro-apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear. {ECO:0000250|UniProtKB:Q9NWB7, ECO:0000269|PubMed:17027958}.
uniprot
proteins
mass_dalton
48772
uniprot
proteins
protein_family
IFT57 family
uniprot
proteins
pubmed
11062270
uniprot
proteins
pubmed
11788820
uniprot
proteins
pubmed
11916979
uniprot
proteins
pubmed
12821668
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17027958
uniprot
proteins
pubmed
17107665
uniprot
proteins
pubmed
17874297
uniprot
proteins
pubmed
17931679
uniprot
proteins
pubmed
18188704
uniprot
proteins
pubmed
19253336
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23810713
uniprot
proteins
pubmed
25860617
uniprot
proteins
pubmed
31637240
uniprot
proteins
sequence_length
429
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000269|PubMed:31637240}. Cytoplasm, cytoskeleton, cilium basal body. Golgi apparatus. Note=Concentrates within the inner segment of cilia.
uniprot
proteins