CCN1
entrez
3491
canonical
uniprot
O00622
canonical
ensembl
ENSG00000142871
resolver
ensp
ENSP00000398736
resolver
enst
ENST00000451137
resolver
genesymbol
CCN1
resolver
genesymbol
CYR61
resolver
genesymbol_syn
CYR61
resolver
genesymbol_syn
GIG1
resolver
genesymbol_syn
IGFBP10
resolver
hgnc
HGNC:2654
resolver
uniprot
D3DT19
resolver
uniprot
O14934
resolver
uniprot
O43775
resolver
uniprot
Q6FI18
resolver
uniprot
Q9BZL7
resolver
uniprot_entry
CCN1_HUMAN
resolver
uniprot_entry
Q6FI18_HUMAN
resolver
uniprot_sec
D3DT19
resolver
uniprot_sec
O14934
resolver
uniprot_sec
O43775
resolver
uniprot_sec
Q9BZL7
resolver
amino_acid_sequence
MSSRIARALALVVTLLHLTRLALSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQLNEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKHQCTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPMEDQDGLLGKELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQGQKCIVQTTSWSQCSKTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKSPEPVRFTYAGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYNCPHANEAAFPFYRLFNDIHKFRD
uniprot
proteins
function
FUNCTION: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3. {ECO:0000269|PubMed:11584015}.
uniprot
proteins
mass_dalton
42027
uniprot
proteins
protein_family
CCN family
uniprot
proteins
pubmed
10446209
uniprot
proteins
pubmed
10821835
uniprot
proteins
pubmed
10852911
uniprot
proteins
pubmed
11287419
uniprot
proteins
pubmed
11584015
uniprot
proteins
pubmed
11810026
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
26091039
uniprot
proteins
pubmed
9135077
uniprot
proteins
pubmed
9446626
uniprot
proteins
pubmed
9536281
uniprot
proteins
sequence_length
381
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins