Sumo1
entrez
22218
canonical
uniprot
P63166
canonical
ensembl
ENSMUSG00000026021
resolver
ensp
ENSMUSP00000088935
resolver
enst
ENSMUST00000091374
resolver
genesymbol
Sumo1
resolver
genesymbol_syn
Smt3c
resolver
genesymbol_syn
Smt3h3
resolver
genesymbol_syn
Ubl1
resolver
uniprot
P55856
resolver
uniprot
Q3TX92
resolver
uniprot
Q93068
resolver
uniprot_entry
SUMO1_MOUSE
resolver
uniprot_sec
P55856
resolver
uniprot_sec
Q3TX92
resolver
uniprot_sec
Q93068
resolver
amino_acid_sequence
MSDQEAKPSTEDLGDKKEGEYIKLKVIGQDSSEIHFKVKMTTHLKKLKESYCQRQGVPMNSLRFLFEGQRIADNHTPKELGMEEEDVIEVYQEQTGGHSTV
uniprot
proteins
function
FUNCTION: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (By similarity). {ECO:0000250|UniProtKB:P63165, ECO:0000269|PubMed:16990542}.
uniprot
proteins
mass_dalton
11557
uniprot
proteins
post_translational_modification
PTM: Cleavage of precursor form by SENP1 or SENP2 is necessary for function. {ECO:0000250|UniProtKB:P63165}.; PTM: Polymeric SUMO1 chains undergo polyubiquitination by RNF4. {ECO:0000250|UniProtKB:P63165}.
uniprot
proteins
protein_family
SUMO subfamily
uniprot
proteins
protein_family
Ubiquitin family
uniprot
proteins
pubmed
15225651
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15767674
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16990542
uniprot
proteins
pubmed
18681895
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
31088288
uniprot
proteins
pubmed
9465300
uniprot
proteins
sequence_length
101
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus membrane {ECO:0000250|UniProtKB:P63165}. Nucleus speckle {ECO:0000269|PubMed:18681895}. Cytoplasm {ECO:0000250|UniProtKB:P63165}. Nucleus, PML body {ECO:0000250|UniProtKB:P63165}. Cell membrane {ECO:0000250|UniProtKB:P63165}. Nucleus {ECO:0000250|UniProtKB:P63165}. Note=Recruited by BCL11A into the nuclear body (PubMed:18681895). In the presence of ZFHX3, sequesterd to nuclear body (NB)-like dots in the nucleus some of which overlap or closely associate with PML body (By similarity). {ECO:0000250|UniProtKB:P63165, ECO:0000269|PubMed:18681895}.
uniprot
proteins