METTL17
entrez
64745
canonical
uniprot
Q9H7H0
canonical
ensembl
ENSG00000165792
resolver
ensp
ENSP00000343041
resolver
ensp
ENSP00000372445
resolver
genesymbol
METTL17
resolver
genesymbol_syn
METT11D1
resolver
hgnc
HGNC:19280
resolver
uniprot
A0A0S2Z5L8
resolver
uniprot
Q9BSH1
resolver
uniprot
Q9BZH2
resolver
uniprot
Q9BZH3
resolver
uniprot_entry
A0A0S2Z5L8_HUMAN
resolver
uniprot_entry
MET17_HUMAN
resolver
uniprot_sec
Q9BSH1
resolver
uniprot_sec
Q9BZH2
resolver
uniprot_sec
Q9BZH3
resolver
amino_acid_sequence
MAAALKCLLTLGRWCPGLGVAPQARALAALVPGVTQVDNKSGFLQKRPHRQHPGILKLPHVRLPQALANGAQLLLLGSAGPTMENQVQTLTSYLWSRHLPVEPEELQRRARHLEKKFLENPDLSQTEEKLRGAVLHALRKTTYHWQELSYTEGLSLVYMAARLDGGFAAVSRAFHEIRARNPAFQPQTLMDFGSGTGSVTWAAHSIWGQSLREYMCVDRSAAMLVLAEKLLKGGSESGEPYIPGVFFRQFLPVSPKVQFDVVVSAFSLSELPSKADRTEVVQTLWRKTGHFLVLVENGTKAGHSLLMDARDLVLKGKEKSPLDPRPGFVFAPCPHELPCPQLTNLACSFSQAYHPIPFSWNKKPKEEKFSMVILARGSPEEAHRWPRITQPVLKRPRHVHCHLCCPDGHMQHAVLTARRHGRDLYRCARVSSWGDLLPVLTPSAFPPSTAQDPSES
uniprot
proteins
function
FUNCTION: Mitochondrial ribosome (mitoribosome) assembly factor (PubMed:36482135, PubMed:38199006). Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body (PubMed:36482135). Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity (PubMed:38234605). {ECO:0000269|PubMed:36482135, ECO:0000269|PubMed:38199006, ECO:0000269|PubMed:38234605}.
uniprot
proteins
mass_dalton
50734
uniprot
proteins
mutagenesis
MUTAGEN 333; /note="C->S: Abolished iron-sulfur-binding, leading to impaired ability to promote mitochondrial ribosome assembly; when associated with S-339, S-347 and S-404."; /evidence="ECO:0000269|PubMed:38199006"; MUTAGEN 339; /note="C->S: Abolished iron-sulfur-binding, leading to impaired ability to promote mitochondrial ribosome assembly; when associated with S-333, S-347 and S-404."; /evidence="ECO:0000269|PubMed:38199006"; MUTAGEN 347; /note="C->S: Abolished iron-sulfur-binding, leading to impaired ability to promote mitochondrial ribosome assembly; when associated with S-333, S-339 and S-404."; /evidence="ECO:0000269|PubMed:38199006"; MUTAGEN 404; /note="C->S: Abolished iron-sulfur-binding, leading to impaired ability to promote mitochondrial ribosome assembly; when associated with S-333, S-339 and S-347."; /evidence="ECO:0000269|PubMed:38199006"; MUTAGEN 424..426; /note="LYR->AAA: Impaired ability to promote mitochondrial ribosome assembly."; /evidence="ECO:0000269|PubMed:38199006
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
protein_family
Rsm22 family
uniprot
proteins
pubmed
11278769
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24137763
uniprot
proteins
pubmed
36482135
uniprot
proteins
pubmed
38199006
uniprot
proteins
pubmed
38234605
uniprot
proteins
sequence_length
456
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:Q3U2U7}.
uniprot
proteins