GPR137B
entrez
7107
canonical
uniprot
O60478
canonical
ensembl
ENSG00000077585
resolver
ensp
ENSP00000355551
resolver
ensp
ENSP00000642162
resolver
ensp
ENSP00000788281
resolver
enst
ENST00000366592
resolver
enst
ENST00000972103
resolver
genesymbol
GPR137B
resolver
genesymbol_syn
TM7SF1
resolver
hgnc
HGNC:11862
resolver
uniprot
Q53EK7
resolver
uniprot
Q5TAE6
resolver
uniprot
Q6FHI3
resolver
uniprot_entry
G137B_HUMAN
resolver
uniprot_sec
Q53EK7
resolver
uniprot_sec
Q5TAE6
resolver
uniprot_sec
Q6FHI3
resolver
amino_acid_sequence
MRPERPRPRGSAPGPMETPPWDPARNDSLPPTLTPAVPPYVKLGLTVVYTVFYALLFVFIYVQLWLVLRYRHKRLSYQSVFLFLCLFWASLRTVLFSFYFKDFVAANSLSPFVFWLLYCFPVCLQFFTLTLMNLYFTQVIFKAKSKYSPELLKYRLPLYLASLFISLVFLLVNLTCAVLVKTGNWERKVIVSVRVAINDTLFVLCAVSLSICLYKISKMSLANIYLESKGSSVCQVTAIGVTVILLYTSRACYNLFILSFSQNKSVHSFDYDWYNVSDQADLKNQLGDAGYVLFGVVLFVWELLPTTLVVYFFRVRNPTKDLTNPGMVPSHGFSPRSYFFDNPRRYDSDDDLAWNIAPQGLQGGFAPDYYDWGQQTNSFLAQAGTLQDSTLDPDKPSLG
uniprot
proteins
function
FUNCTION: Lysosomal integral membrane protein that regulates the localization and activity of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids (PubMed:31036939). Interacts with Rag GTPases and increases the lysosomal localization and activity of Rag GTPases and thereby regulates mTORC1 translocation and activity in lysosome (PubMed:31036939). Involved in the regulation of lysosomal morphology and autophagy (PubMed:31036939). {ECO:0000269|PubMed:31036939}.; FUNCTION: Also acts as a negative regulator of osteoclast activity (By similarity). Involved in interleukin-4-induced M2 macrophage polarization (By similarity). {ECO:0000250|UniProtKB:Q8BNQ3}.
uniprot
proteins
mass_dalton
45599
uniprot
proteins
protein_family
GPR137 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
22729905
uniprot
proteins
pubmed
31036939
uniprot
proteins
pubmed
9521871
uniprot
proteins
sequence_length
399
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:22729905, ECO:0000269|PubMed:31036939}; Multi-pass membrane protein {ECO:0000269|PubMed:22729905}. Note=Colocalized with MTOR in lysosome after amino acid stimulation. {ECO:0000269|PubMed:31036939}.
uniprot
proteins
transmembrane_region
TRANSMEM 47..67; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 80..100; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 112..132; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 160..180; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 189..209; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 238..258; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 293..313; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins