P0C5E3
uniprot
P0C5E3
canonical
amino_acid_sequence
PEEICTLVIAESFPEDAGIFTCSARNDYGSVTSTAQLVVTSANTENCSYDSMGEPNSDHFQHFPPPPPILETGSYELASQKPSEIQQVNTPNLGFNMAALQMQFNSAERETNGVHPSHGVNGLINGKAYGNKSPPTPAALLSPTKEPPPLLAKPKLGFPKKASRTARIASDEEIQGTKDAVIQDLERKLRFKEDLLNNGQPRLTYEERMARRLLGADSANVFNIQEPEETAANQEYKVSSCEQRLISEIEYRLERSPVEESGDEVQEAEVPVENAAAPFFEMKLKHYKIFEGMPVTFTCRVAGSPKPKIYWFKDGKQISPKSDHYTIQRDVDGTCSLHTTASTLDDDGNYTIMAANTQGRVSCTGRLMVQAVNQRGRSPRSPPGHPHARRPRSRSRDSGDENEPIQERFFRPHFLQAPGDLTVQEGKLCRMDCKVSGLPTPDLSWQLDGKPIRPDSAHKMLVRENGVHSLIIEPVTSRDAGIYTCIATNRAGQNSFNLELVVAAKEAHKAPVFIEKLQNTGVADGYPVRLECRVSGVPPPQIFWKKENESLTHSTDRVSMHQDNHGYICLLIQGATKEDAGWYTVSAKNEAGIVSCTARLDVY
uniprot
proteins
function
FUNCTION: Cytoskeletal protein required for organization of normal actin cytoskeleton. Roles in establishing cell morphology, motility, cell adhesion and cell-extracellular matrix interactions in a variety of cell types. May function as a scaffolding molecule with the potential to influence both actin polymerization and the assembly of existing actin filaments into higher-order arrays. Binds to proteins that bind to either monomeric or filamentous actin. Localizes at sites where active actin remodeling takes place, such as lamellipodia and membrane ruffles. Different isoforms may have functional differences. Plays a role in neurite outgrowth and in the establishment of polarity during neuronal morphogenesis. Participates in the acquisition of the reactive astrocyte morphology. {ECO:0000269|PubMed:10931874, ECO:0000269|PubMed:11553711, ECO:0000269|PubMed:12932445, ECO:0000269|PubMed:16868024}.
uniprot
proteins
mass_dalton
66705
uniprot
proteins
post_translational_modification
PTM: Phosphorylated predominantly on serines and, to a lesser extent, on tyrosines. Phosphorylation at Ser-395 by PKB/AKT1 modulates cytoskeletal organization and cell motility (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Myotilin/palladin family
uniprot
proteins
pubmed
10931874
uniprot
proteins
pubmed
11438925
uniprot
proteins
pubmed
11553711
uniprot
proteins
pubmed
12932445
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
16125169
uniprot
proteins
pubmed
16868024
uniprot
proteins
pubmed
22659164
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
23565266
uniprot
proteins
sequence_length
603
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16125169, ECO:0000269|PubMed:16868024}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:Q8WX93}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:11553711, ECO:0000269|PubMed:16125169}. Cell projection, ruffle {ECO:0000269|PubMed:16868024}. Cell projection, podosome {ECO:0000269|PubMed:16868024}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q8WX93}. Cell projection, axon {ECO:0000269|PubMed:11438925, ECO:0000269|PubMed:11553711}. Cell projection, growth cone {ECO:0000269|PubMed:11438925, ECO:0000269|PubMed:11553711}. Note=Localizes to stress fibers (PubMed:11553711, PubMed:16125169, PubMed:16868024, PubMed:22659164). Localizes to Z lines (PubMed:11553711, PubMed:16125169, PubMed:16868024). Preferentially expressed in the excitatory presynaptic terminals (PubMed:11438925). {ECO:0000269|PubMed:11438925, ECO:0000269|PubMed:11553711, ECO:0000269|PubMed:16125169, ECO:0000269|PubMed:16868024, ECO:0000269|PubMed:22659164}.
uniprot
proteins