Mbd5
entrez
109241
canonical
uniprot
B1AYB6
canonical
ensembl
ENSMUSG00000036792
resolver
ensp
ENSMUSP00000036847
resolver
ensp
ENSMUSP00000119317
resolver
ensp
ENSMUSP00000285076
resolver
ensp
ENSMUSP00000285078
resolver
enst
ENSMUST00000047413
resolver
genesymbol
Mbd5
resolver
genesymbol_syn
mKIAA1461
resolver
uniprot
B1AYB5
resolver
uniprot
B1AYB7
resolver
uniprot
Q69ZJ2
resolver
uniprot_entry
B1AYB5_MOUSE
resolver
uniprot_entry
MBD5_MOUSE
resolver
uniprot_entry
Q69ZJ2_MOUSE
resolver
uniprot_sec
B1AYB7
resolver
amino_acid_sequence
MNGGKECDGGDKEGGLAAIQVPVGWQRRVDHNGVLYISPSGSLLSCLDQVKTYLLTDGTCKCGLECPLILPKVFNFDPGAAVKQRTAEDVKADDDVTKLCIHKRKIIAVATLHQSMEAPHPSLVLTSPGGGTNATPVVPSRAATPRSVRNKSHEGITNSVMPECKNPFKLMTGSSNAMGRLYMQDLPGSQQQELHPVYPRQRLGSSEHGQKSPFRGSHGGLPSPASSGSQIYGDGSISPRTDPLGSPDVFTRNNPGFHGAPNSSPIHLNRTPLSPPSVMLHGSPVQSSCAMAGRTNIPLSPTLTTKSPVMKKPMCNFSTNMEIPRAMFHHKPPQGPPPPPPPSCALQKKPLTSEKDPLGILDPIPSKPVNQNPIIINPTSFHSNVHSQVPVMNVSMPPAVVPLPSNLPLPTVKPGHMNHGSHVQRIQHSASTSLSPSPVTSPVHMMGTGIGRIEASPQRSRSSSTSSDHGNFMMPPVGPQATCSGIKVPPRSPRSTIGSPRPSMPSSPSTKSDGHHQYKDIPNPLIAGMSNVLNTPSSAAFPTAPAGNGSVKSQPGLLGMPLNQILNQHNAASFPASSLLSAAAKAQLANQNKLAGNNSSSSNNSGAVASSGNTEGHSTLNTMFPPTANMLLPTGEGQSGRAALRDKLMSQQKDSLRKRKQPPTTVLSLLRQSQMDSSAAPKPGPDLLRKHGQGSFPISSMSQLLQSMSCQSSHLSSNSTPGCGGSNTALPCSANQLHFPDPNMNSTVLQNSLTQSIPLRGEAVHCHNANTNFVHSNSPVPNHHLAGLINQIQASGNCGMLSQSGMALGNSLHPNPPQSRISTSSTPVIPNSIVSSYNQTSSEAGGSSLPSSIAIAGSNHPAITKTTSVLQDGVIVTTAAGNPLQSQLPIGSDFPFVGQEHALHFPSNSTANNHLPHPLNPSLLSSLPISLPVNQQHLLNQNLLNILQPSAGEGDISSINNSLNNHQLTHLQSLLNSNQMFPPNQQPQQHLLQGHQNLQAFQGQPTVPCPANNNPMACLFQNFQVRMQGDAALLNKRISTQPGLTTLPENPNLALPHFQDTPCELQPRIDLGQPMKDGLVMGGQGDASVDAIYKAVVDAASKGMQVVITTAVNSTTQISPIPALSAMSAFTASIGDPLNLSSAVSAVIHGRNMGGVDHDGRLRNARGARLPKNIDHGKNSSEGDGFECFKSASCHTSRKQWDGEQSPRGERNRWKYEEFLDHPGHIHSSPCHERPNNVSTLPFLAGEQHPILLPPRNCQGDKILEENFRYNNYKRTMMSFKERLESTVERCTHINGNRPRQSRGFGELLGTAKQDLVLEGQSPGSSNSLESSLVKDYIHYNGDFNAKTINGCVPSPSDAKSISSEDDLRNPDSPSSHELIHYRPRTFNVGDLVWGQIKGLTSWPGKFIREDDVHNSCQQSPEEGKVEPEKLKTLTEGLEAYSRVRKRSRKSGKLNNHLEAAIHEAMSELDKMSGTVHQIPQGDRQMRPPKPKRRKISR
uniprot
proteins
function
FUNCTION: Non-catalytic component of the polycomb repressive deubiquitinase (PR-DUB) complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-120' (H2AK119ub1). Important for stability of PR-DUB components and stimulating its ubiquitinase activity. As part of the PR-DUB complex, associates with chromatin enriched in histone marks H3K4me1, H3K4me3, and H3K27Ac, but not in H3K27me3. The PR-DUB complex is an epigenetic regulator of gene expression, including genes involved in cell growth and survivability. MBD5 and MBD6 containing complexes associate with distinct chromatin regions enriched in genes involved in different pathways. Heterochromatin recruitment is not mediated by DNA methylation. The PR-DUB complex is an epigenetic regulator of gene expression, including genes involved in development, cell communication, signaling, cell proliferation and cell viability. {ECO:0000250|UniProtKB:Q9P267}.
uniprot
proteins
mass_dalton
160292
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20700456
uniprot
proteins
sequence_length
1498
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Nucleus {ECO:0000250|UniProtKB:Q9P267}. Chromosome {ECO:0000250|UniProtKB:Q9P267}. Note=Associates with heterochromatin containing chromocentres in a DNA methylation-independent manner. Does not localize to sites of DNA damage. {ECO:0000250|UniProtKB:Q9P267}.; SUBCELLULAR LOCATION: [Isoform 2]: Nucleus {ECO:0000250|UniProtKB:Q9P267}. Note=Does not associate with heterochromatin containing chromocentres. Does not localize to sites of DNA damage. {ECO:0000250|UniProtKB:Q9P267}.
uniprot
proteins