MAEA
entrez
10296
canonical
uniprot
Q7L5Y9
canonical
ensembl
ENSG00000090316
resolver
ensp
ENSP00000264750
resolver
ensp
ENSP00000302830
resolver
ensp
ENSP00000421644
resolver
ensp
ENSP00000424436
resolver
ensp
ENSP00000426807
resolver
ensp
ENSP00000427512
resolver
ensp
ENSP00000538712
resolver
ensp
ENSP00000692367
resolver
ensp
ENSP00000778147
resolver
enst
ENST00000505839
resolver
enst
ENST00000510794
resolver
enst
ENST00000514708
resolver
genesymbol
MAEA
resolver
genesymbol_syn
EMP
resolver
hgnc
HGNC:13731
resolver
uniprot
B3KRN7
resolver
uniprot
B4DJP8
resolver
uniprot
B4DQT1
resolver
uniprot
B4DVN3
resolver
uniprot
D6RIB6
resolver
uniprot
F6S2M2
resolver
uniprot
F6UB65
resolver
uniprot
O95285
resolver
uniprot
Q5JB54
resolver
uniprot
Q6ZRD6
resolver
uniprot
Q9BQ11
resolver
uniprot
Q9H9V6
resolver
uniprot
Q9H9Z4
resolver
uniprot
Q9NW84
resolver
uniprot_entry
B3KRN7_HUMAN
resolver
uniprot_entry
B4DJP8_HUMAN
resolver
uniprot_entry
B4DQT1_HUMAN
resolver
uniprot_entry
B4DVN3_HUMAN
resolver
uniprot_entry
D6RIB6_HUMAN
resolver
uniprot_entry
F6S2M2_HUMAN
resolver
uniprot_entry
F6UB65_HUMAN
resolver
uniprot_entry
MAEA_HUMAN
resolver
uniprot_sec
O95285
resolver
uniprot_sec
Q5JB54
resolver
uniprot_sec
Q6ZRD6
resolver
uniprot_sec
Q9BQ11
resolver
uniprot_sec
Q9H9V6
resolver
uniprot_sec
Q9H9Z4
resolver
uniprot_sec
Q9NW84
resolver
amino_acid_sequence
MAVQESAAQLSMTLKVQEYPTLKVPYETLNKRFRAAQKNIDRETSHVTMVVAELEKTLSGCPAVDSVVSLLDGVVEKLSVLKRKAVESIQAEDESAKLCKRRIEHLKEHSSDQPAAASVWKRKRMDRMMVEHLLRCGYYNTAVKLARQSGIEDLVNIEMFLTAKEVEESLERRETATCLAWCHDNKSRLRKMKSCLEFSLRIQEFIELIRQNKRLDAVRHARKHFSQAEGSQLDEVRQAMGMLAFPPDTHISPYKDLLDPARWRMLIQQFRYDNYRLHQLGNNSVFTLTLQAGLSAIKTPQCYKEDGSSKSPDCPVCSRSLNKLAQPLPMAHCANSRLVCKISGDVMNENNPPMMLPNGYVYGYNSLLSIRQDDKVVCPRTKEVFHFSQAEKVYIM
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). MAEA is required for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972). Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (By similarity). Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (PubMed:9763581). Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity). May contribute to nuclear architecture and cells division events (Probable). {ECO:0000250|UniProtKB:Q4VC33, ECO:0000269|PubMed:29911972, ECO:0000269|PubMed:9763581, ECO:0000305|PubMed:16510120}.
uniprot
proteins
mass_dalton
45287
uniprot
proteins
post_translational_modification
PTM: Autoubiquitinated as component of the CTLH E3 ubiquitin-protein ligase complex (in vitro). {ECO:0000269|PubMed:29911972}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16510120
uniprot
proteins
pubmed
17467196
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24143168
uniprot
proteins
pubmed
29911972
uniprot
proteins
pubmed
9763581
uniprot
proteins
sequence_length
396
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q4VC33}. Nucleus, nucleoplasm {ECO:0000269|PubMed:17467196, ECO:0000269|PubMed:24143168, ECO:0000269|PubMed:29911972}. Nucleus matrix {ECO:0000269|PubMed:16510120}. Cell membrane {ECO:0000269|PubMed:9763581}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:16510120}. Note=Detected in a nuclear, speckled-like pattern (PubMed:16510120). Localized with condensed chromatin at prophase; Detected in nuclear spindle poles at metaphase and in the contractile ring during telophase and cytokinesis (PubMed:16510120). Present in cytoplasm, nuclear matrix and at the cell surface in macrophages; predominantly nuclear in immature macrophages and predominantly detected at the cell surface in mature macrophages. Colocalizes with F-actin in macrophages (By similarity). {ECO:0000250|UniProtKB:Q4VC33, ECO:0000269|PubMed:16510120}.
uniprot
proteins