RIDA
entrez
10247
canonical
uniprot
P52758
canonical
ensembl
ENSG00000132541
resolver
ensp
ENSP00000254878
resolver
enst
ENST00000254878
resolver
genesymbol
RIDA
resolver
genesymbol_syn
HRSP12
resolver
hgnc
HGNC:16897
resolver
uniprot
Q6FHU9
resolver
uniprot
Q6IBG0
resolver
uniprot_entry
RIDA_HUMAN
resolver
uniprot_sec
Q6FHU9
resolver
uniprot_sec
Q6IBG0
resolver
amino_acid_sequence
MSSLIRRVISTAKAPGAIGPYSQAVLVDRTIYISGQIGMDPSSGQLVSGGVAEEAKQALKNMGEILKAAGCDFTNVVKTTVLLADINDFNTVNEIYKQYFKSNFPARAAYQVAALPKGSRIEIEAVAIQGPLTTASL
uniprot
proteins
ec_number
3.5.99.10
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase. {ECO:0000269|PubMed:20817725, ECO:0000269|PubMed:22094463}.; FUNCTION: Also promotes endoribonucleolytic cleavage of some transcripts by promoting recruitment of the ribonuclease P/MRP complex (PubMed:30930054, PubMed:8973653). Acts by bridging YTHDF2 and the ribonuclease P/MRP complex (PubMed:30930054). RIDA/HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs containing a 5'-GGUUC-3' motif: cooperative binding of RIDA/HRSP12 and YTHDF2 to such transcripts lead to recruitment of the ribonuclease P/MRP complex and subsequent endoribonucleolytic cleavage (PubMed:30930054). {ECO:0000269|PubMed:30930054, ECO:0000269|PubMed:8973653}.
uniprot
proteins
mass_dalton
14494
uniprot
proteins
protein_family
RutC family
uniprot
proteins
pubmed
14997576
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20817725
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22094463
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
30930054
uniprot
proteins
pubmed
8973653
uniprot
proteins
pubmed
9141440
uniprot
proteins
sequence_length
137
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8973653}. Nucleus {ECO:0000269|PubMed:8973653}. Peroxisome {ECO:0000250|UniProtKB:P52759}. Mitochondrion {ECO:0000250|UniProtKB:P52759}. Note=Mostly cytoplasmic but, in less differentiated cells occasionally nuclear. {ECO:0000269|PubMed:8973653}.
uniprot
proteins