CAMK2N1
entrez
55450
canonical
uniprot
Q7Z7J9
canonical
ensembl
ENSG00000162545
resolver
ensp
ENSP00000364219
resolver
enst
ENST00000375078
resolver
genesymbol
CAMK2N1
resolver
hgnc
HGNC:24190
resolver
uniprot_entry
CK2N1_HUMAN
resolver
amino_acid_sequence
MSEVLPYGDEKLSPYGDGGDVGQIFSCRLQDTNNFFGAGQNKRPPKLGQIGRSKRVVIEDDRIDDVLKNMTDKAPPGV
uniprot
proteins
function
FUNCTION: Potent and specific inhibitor of CaM-kinase II (CAMK2) (By similarity). Plays a role in the maintenance of long-term retrieval-induced memory in response to contextual fear (By similarity). Modulates blood pressure and vascular reactivity via regulation of CAMK2 activity in addition to regulation of left ventricular mass (By similarity). Mediates the NLRP3 inflammasome in cardiomyocytes via acting as an inhibitor of the MAPK14/p38 and MAPK8/JNK pathways, thereby regulating ventricular remodeling and cardiac rhythm post-myocardial infarction (By similarity). Negatively effects insulin sensitivity and promotes lipid formation in adipose tissues independent of CAMK2 signaling (By similarity). {ECO:0000250|UniProtKB:Q6QWF9, ECO:0000250|UniProtKB:Q9JI15}.
uniprot
proteins
mass_dalton
8553
uniprot
proteins
protein_family
CAMK2N family
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18305109
uniprot
proteins
pubmed
34237910
uniprot
proteins
sequence_length
78
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Synapse {ECO:0000250|UniProtKB:Q6QWF9}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9JI15}. Postsynaptic density {ECO:0000250|UniProtKB:Q6QWF9}.
uniprot
proteins