Irf2bp2
entrez
270110
canonical
uniprot
E9Q1P8
canonical
ensembl
ENSMUSG00000051495
resolver
ensp
ENSMUSP00000062753
resolver
enst
ENSMUST00000054960
resolver
genesymbol
Irf2bp2
resolver
uniprot
Q8BJC6
resolver
uniprot_entry
I2BP2_MOUSE
resolver
uniprot_sec
Q8BJC6
resolver
amino_acid_sequence
MAAAVAVAAASRRQSCYLCDLPRMPWAMIWDFTEPVCRGCVNYEGADRVEFVIETARQLKRAHGCFPEGRSPTGAQPAAAKPPPLSAKDLLLQPPPQLGHAGAEAARAQAMERYPLAPDRAPRLASDFSTRAGAGLPQSAAQQSAPANGILVPNGFSKLEEPPELNRQSPNPRRAHAVPPTLVPLVNGSAALGLSGRAAATLAAVSGTPGLGAQPAELGTHKRPASVSSAAAEHEAREPSKEKAQPAHRSPADSLSSAAGASELSAEGAGKGRAPGEQDWASRPKTVRDTLLALHQHGHSGPFESKFKKEPALTAAGRLLGFEANGANGSKAVARTARKRKPSPEPEGEVGPPKINGETQPWLSTSTEGLKIPITPTSSFVSPPPPTASPHSNRTTPPEAAQNGQSPMAALILVADNAGGSHASKDATQVHSTTRRNSSSPPSPSSMNQRRLGPREVGGQATGSTGGLEPVHPASLPDSSLAASAPLCCTLCHERLEDTHFVQCPSVPSHKFCFPCSRQSIKQQGASGEVYCPSGEKCPLVGSNVPWAFMQGEIATILAGDVKVKKERDS
uniprot
proteins
function
FUNCTION: Acts as a transcriptional corepressor in a IRF2-dependent manner, this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles. Plays a role in immature B-cell differentiation (By similarity). {ECO:0000250|UniProtKB:Q7Z5L9}.
uniprot
proteins
mass_dalton
59292
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-343 is required for nuclear targeting. {ECO:0000250}.
uniprot
proteins
protein_family
IRF2BP family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
570
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
uniprot
proteins