Il5
entrez
16191
canonical
uniprot
P04401
canonical
ensembl
ENSMUSG00000036117
resolver
ensp
ENSMUSP00000043369
resolver
genesymbol
Il5
resolver
genesymbol_syn
IL5
resolver
genesymbol_syn
Il-5
resolver
uniprot
Q05A89
resolver
uniprot
Q5SV01
resolver
uniprot_entry
IL5_MOUSE
resolver
uniprot_entry
Q5SV01_MOUSE
resolver
uniprot_sec
Q05A89
resolver
amino_acid_sequence
MRRMLLHLSVLTLSCVWATAMEIPMSTVVKETLTQLSAHRALLTSNETMRLPVPTHKNHQLCIGEIFQGLDILKNQTVRGGTVEMLFQNLSLIKKYIDRQKEKCGEERRRTRQFLDYLQEFLGVMSTEWAMEG
uniprot
proteins
function
FUNCTION: Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils (PubMed:10444455, PubMed:1873482). Also acts on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation (PubMed:3128631). Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively (By similarity). {ECO:0000250|UniProtKB:P05113, ECO:0000269|PubMed:10444455, ECO:0000269|PubMed:1873482, ECO:0000269|PubMed:3128631}.
uniprot
proteins
mass_dalton
15410
uniprot
proteins
protein_family
IL-5 family
uniprot
proteins
pubmed
10444455
uniprot
proteins
pubmed
1873482
uniprot
proteins
pubmed
2215480
uniprot
proteins
pubmed
3024009
uniprot
proteins
pubmed
3078564
uniprot
proteins
pubmed
3128631
uniprot
proteins
pubmed
3133208
uniprot
proteins
pubmed
32211550
uniprot
proteins
sequence_length
133
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:32211550}.
uniprot
proteins