FRMPD2
entrez
143162
canonical
uniprot
Q68DX3
canonical
ensembl
ENSG00000170324
resolver
ensp
ENSP00000307079
resolver
ensp
ENSP00000363317
resolver
ensp
ENSP00000781937
resolver
genesymbol
FRMPD2
resolver
genesymbol_syn
PDZD5C
resolver
genesymbol_syn
PDZK4
resolver
genesymbol_syn
PDZK5C
resolver
hgnc
HGNC:28572
resolver
uniprot
B4E1N9
resolver
uniprot
B7WNW0
resolver
uniprot
B7ZML5
resolver
uniprot
Q2VY07
resolver
uniprot
Q6GMQ9
resolver
uniprot
Q6ZN38
resolver
uniprot
Q6ZWI2
resolver
uniprot
Q8N5T9
resolver
uniprot_entry
B4E1N9_HUMAN
resolver
uniprot_entry
FRPD2_HUMAN
resolver
uniprot_sec
B7WNW0
resolver
uniprot_sec
B7ZML5
resolver
uniprot_sec
Q2VY07
resolver
uniprot_sec
Q6GMQ9
resolver
uniprot_sec
Q6ZN38
resolver
uniprot_sec
Q6ZWI2
resolver
uniprot_sec
Q8N5T9
resolver
amino_acid_sequence
MQPLTKDAGMSLSSVTLASALQVRGEALSEEEIWSLLFLAAEQLLEDLRNDSSDYVVCPWSALLSAAGSLSFQGRVSHIEAAPFKAPELLQGQSEDEQPDASQMHVYSLGMTLYWSAGFHVPPHQPLQLCEPLHSILLTMCEDQPHRRCTLQSVLEACRVHEKEVSVYPAPAGLHIRRLVGLVLGTISEVEKRVVEESSSVQQNRSYLLRKRLRGTSSESPAAQAPECLHPCRVSERSTETQSSPEPHWSTLTHSHCSLLVNRALPGADPQDQQAGRRLSSGSVHSAADSSWPTTPSQRGFLQRRSKFSRPEFILLAGEAPMTLHLPGSVVTKKGKSYLALRDLCVVLLNGQHLEVKCDVESTVGAVFNAVTSFANLEELTYFGLAYMKSKEFFFLDSETRLCKIAPEGWREQPQKTSMNTFTLFLRIKFFVSHYGLLQHSLTRHQFYLQLRKDILEERLYCNEEILLQLGVLALQAEFGNYPKEQVESKPYFHVEDYIPASLIERMTALRVQVEVSEMHRLSSALWGEDAELKFLRVTQQLPEYGVLVHQVFSEKRRPEEEMALGICAKGVIVYEVKNNSRIAMLRFQWRETGKISTYQKKFTITSSVTGKKHTFVTDSAKTSKYLLDLCSAQHGFNAQMGSGQPSHVLFDHDKFVQMANLSPAHQARSKPLIWIQRLSCSENELFVSRLQGAAGGLLSTSMDNFNVDGSKEAGAEGIGRSPCTGREQLKSACVIQKPMTWDSLSGPPVQSMHAGSKNNRRKSFIAEPGREIVRVTLKRDPHRGFGFVINEGEYSGQADPGIFISSIIPGGPAEKAKTIKPGGQILALNHISLEGFTFNMAVRMIQNSPDNIELIISQSKGVGGNNPDEEKNSTANSGVSSTDILSFGYQGSLLSHTQDQDRNTEELDMAGVQSLVPRLRHQLSFLPLKGAGSSCPPSPPEISAGEIYFVELVKEDGTLGFSVTGGINTSVPYGGIYVKSIVPGGPAAKEGQILQGDRLLQVDGVILCGLTHKQAVQCLTGPGQVARLVLERRVPRSTQQCPSANDSMGDERTAVSLVTALPGRPSSCVSVTDGPKFEVKLKKNANGLGFSFVQMEKESCSHLKSDLVRIKRLFPGQPAEENGAIAAGDIILAVNGRSTEGLIFQEVLHLLRGAPQEVTLLLCRPPPGALPELEQEWQTPELSADKEFTRATCTDSCTSPILDQEDSWRDSASPDAGEGLGLRPESSQKAIREAQWGQNRERPWASSLTHSPESHPHLCKLHQERDESTLATSLEKDVRQNCYSVCDIMRLGRYSFSSPLTRLSTDIF
uniprot
proteins
function
FUNCTION: Functions as a scaffold protein and likely plays a role in N-methyl-D-aspartic acid receptor (NMDAR)-mediated synaptic excitatory transmission (By similarity). May be involved in synapse formation in cone photoreceptor cells (By similarity). May play a role in the regulation of tight junction formation (PubMed:19706687). Binds phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:19706687). May play a role in the regulation of NOD2-mediated NF-kappa-B activation in immune response (PubMed:23213202). {ECO:0000250|UniProtKB:A0A140LI67, ECO:0000269|PubMed:19706687, ECO:0000269|PubMed:23213202}.
uniprot
proteins
mass_dalton
144282
uniprot
proteins
mutagenesis
MUTAGEN 955; /note="K->E: Abolishes the basolateral membrane localization."; /evidence="ECO:0000269|PubMed:19706687
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19706687
uniprot
proteins
pubmed
22068589
uniprot
proteins
pubmed
23213202
uniprot
proteins
sequence_length
1309
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Basolateral cell membrane {ECO:0000269|PubMed:19706687, ECO:0000269|PubMed:23213202}. Cell junction, tight junction {ECO:0000269|PubMed:19706687}. Postsynaptic density {ECO:0000250|UniProtKB:A0A140LI67}. Note=Colocalizes with CTNNB1, CDH1 and PKP4 at the basolateral membrane. Colocalizes with TJP1 at tight junctions. Its recruitment to cell-cell contacts requires CDH1. Colocalizes with NOD2 to the basolacteral membrane in intestinal epithelial cells (PubMed:23213202). {ECO:0000269|PubMed:23213202}.
uniprot
proteins