RPN2
entrez
6185
canonical
uniprot
P04844
canonical
ensembl
ENSG00000118705
resolver
ensembl
ENSG00000291973
resolver
ensp
ENSP00000237530
resolver
ensp
ENSP00000362724
resolver
ensp
ENSP00000562679
resolver
ensp
ENSP00000562684
resolver
ensp
ENSP00000562694
resolver
ensp
ENSP00000584641
resolver
ensp
ENSP00000698040
resolver
ensp
ENSP00000769966
resolver
genesymbol
RPN2
resolver
hgnc
HGNC:10382
resolver
uniprot
Q5JYR6
resolver
uniprot
Q6IBA5
resolver
uniprot
Q96E21
resolver
uniprot
Q9BUQ3
resolver
uniprot
Q9UBE1
resolver
uniprot_entry
RPN2_HUMAN
resolver
uniprot_sec
Q5JYR6
resolver
uniprot_sec
Q6IBA5
resolver
uniprot_sec
Q96E21
resolver
uniprot_sec
Q9BUQ3
resolver
uniprot_sec
Q9UBE1
resolver
amino_acid_sequence
MAPPGSSTVFLLALTIIASTWALTPTHYLTKHDVERLKASLDRPFTNLESAFYSIVGLSSLGAQVPDAKKACTYIRSNLDPSNVDSLFYAAQASQALSGCEISISNETKDLLLAAVSEDSSVTQIYHAVAALSGFGLPLASQEALSALTARLSKEETVLATVQALQTASHLSQQADLRSIVEEIEDLVARLDELGGVYLQFEEGLETTALFVAATYKLMDHVGTEPSIKEDQVIQLMNAIFSKKNFESLSEAFSVASAAAVLSHNRYHVPVVVVPEGSASDTHEQAILRLQVTNVLSQPLTQATVKLEHAKSVASRATVLQKTSFTPVGDVFELNFMNVKFSSGYYDFLVEVEGDNRYIANTVELRVKISTEVGITNVDLSTVDKDQSIAPKTTRVTYPAKAKGTFIADSHQNFALFFQLVDVNTGAELTPHQTFVRLHNQKTGQEVVFVAEPDNKNVYKFELDTSERKIEFDSASGTYTLYLIIGDATLKNPILWNVADVVIKFPEEEAPSTVLSQNLFTPKQEIQHLFREPEKRPPTVVSNTFTALILSPLLLLFALWIRIGANVSNFTFAPSTIIFHLGHAAMLGLMYVYWTQLNMFQTLKYLAILGSVTFLAGNRMLAQQAVKRTAH
uniprot
proteins
function
FUNCTION: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. {ECO:0000250|UniProtKB:F1PCT7, ECO:0000269|PubMed:31831667}.
uniprot
proteins
mass_dalton
69284
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:31831667}.
uniprot
proteins
protein_family
SWP1 family
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23606741
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25135935
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
29290612
uniprot
proteins
pubmed
3034581
uniprot
proteins
pubmed
31831667
uniprot
proteins
pubmed
36697828
uniprot
proteins
pubmed
38670073
uniprot
proteins
sequence_length
631
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:F1PCT7}. Endoplasmic reticulum membrane; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 541..561; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 572..592; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 597..617; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins