Chac1
entrez
362196
canonical
uniprot
B3STU3
canonical
ensembl
ENSRNOG00000014387
resolver
ensembl
ENSRNOG00055003272
resolver
ensembl
ENSRNOG00060026373
resolver
ensembl
ENSRNOG00065023817
resolver
ensp
ENSRNOP00000019392
resolver
ensp
ENSRNOP00055003771
resolver
ensp
ENSRNOP00060037894
resolver
ensp
ENSRNOP00065033307
resolver
enst
ENSRNOT00000019392
resolver
enst
ENSRNOT00055005074
resolver
enst
ENSRNOT00060045661
resolver
enst
ENSRNOT00065040821
resolver
genesymbol
Chac1
resolver
genesymbol_syn
Botch
resolver
genesymbol_syn
Npg7
resolver
uniprot_entry
CHAC1_RAT
resolver
amino_acid_sequence
MKQESAAQSTPPPSLSPAPSAQPSWEDGDPQALWIFGYGSLVWKPDFAYSDSRVGFVRGYSRRFWQGDTFHRGSDKMPGRVVTLLEDHEGCTWGVAYQVRGEQVSEALKYLNVREAVLGGYDTKEVTFYPQDTPDQPLTALAYVATPQNPGYLGPAPEEVIATQILACRGFSGHNLEYLLRLADFMQLCGPQAQDEHLEAIVDAVGSLLPCSYLSEQPLALI
uniprot
proteins
ec_number
4.3.2.7
uniprot
proteins
function
FUNCTION: Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution. Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade. Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos. {ECO:0000250|UniProtKB:Q9BUX1}.
uniprot
proteins
mass_dalton
24457
uniprot
proteins
protein_family
ChaC subfamily
uniprot
proteins
protein_family
Gamma-glutamylcyclotransferase family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
21124846
uniprot
proteins
sequence_length
222
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9BUX1}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:Q8R3J5}.
uniprot
proteins