PTCHD4
entrez
442213
canonical
uniprot
Q6ZW05
canonical
ensembl
ENSG00000244694
resolver
ensp
ENSP00000341914
resolver
ensp
ENSP00000381722
resolver
enst
ENST00000398738
resolver
genesymbol
PTCHD4
resolver
genesymbol_syn
C6orf138
resolver
genesymbol_syn
PTCH53
resolver
hgnc
HGNC:21345
resolver
uniprot
A0A0A7EN49
resolver
uniprot
B0QZ29
resolver
uniprot
B2RPC0
resolver
uniprot
B4DRK3
resolver
uniprot
B4DTR9
resolver
uniprot
H0Y3Q6
resolver
uniprot
Q5T884
resolver
uniprot_entry
H0Y3Q6_HUMAN
resolver
uniprot_entry
PTHD4_HUMAN
resolver
uniprot_sec
A0A0A7EN49
resolver
uniprot_sec
B0QZ29
resolver
uniprot_sec
B2RPC0
resolver
uniprot_sec
B4DRK3
resolver
uniprot_sec
B4DTR9
resolver
uniprot_sec
Q5T884
resolver
amino_acid_sequence
MCFLRRPGAPASWIWWRMLRQVLRRGLQSFCHRLGLCVSRHPVFFLTVPAVLTITFGLSALNRFQPEGDLERLVAPSHSLAKIERSLASSLFPLDQSKSQLYSDLHTPGRYGRVILLSPTGDNILLQAEGILQTHRAVLEMKDGRNSFIGHQLGGVVEVPNSKDQRVKSARAIQITYYLQTYGSATQDLIGEKWENEFCKLIRKLQEEHQELQLYSLASFSLWRDFHKTSILARSKVLVSLVLILTTATLSSSMKDCLRSKPFLGLLGVLTVCISIITAAGIFFITDGKYNSTLLGIPFFAMGHGTKGVFELLSGWRRTKENLPFKDRIADAYSDVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFCQNMCVSILLNYFYIFSFFGSCLVFAGQLEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSDGHQQTSHHETNPYQHHFIQHFLREHYNEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLASDSPSVSYAMVQQKYFSNYSPVIGFYVYEPLEYWNSSVQDDLRRLCSGFTAVSWVEQYYQFLKVSNVSANNKSDFISVLQSSFLKKPEFQHFRNDIIFSKAGDESNIIASRLYLVARTSRDKQKEITEVLEKLRPLSLSKSIRFIVFNPSFVFMDHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLGNFWLILSVTSIELGVLGLMTLWNVDMDCISILCLIYTLNFAIDHCAPLLFTFVLATEHTRTQCIKSSLQDHGTAILQNVTSFLIGLVPLLFVPSNLTFTLFKCLLLTGGCTLLHCFVILPVFLTFFPPSKKHHKKKKRAKRKEREEIECIEIQENPDHVTTV
uniprot
proteins
function
FUNCTION: Could act as a repressor of canonical hedgehog signaling by antagonizing the effects of SMO, as suggested by down-regulation of hedgehog target genes, including GLI1, PTCH1, and PTCH2 in PTCHD4-expressing cells. {ECO:0000269|PubMed:25296753}.
uniprot
proteins
mass_dalton
96371
uniprot
proteins
protein_family
Patched family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
25296753
uniprot
proteins
sequence_length
846
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 41..61; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 230..250; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 265..285; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 293..313; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 336..356; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 373..393; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 465..485; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 660..680; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 686..706; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 718..738; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 765..785; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 787..807; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins