Alcam
entrez
11658
canonical
uniprot
Q61490
canonical
ensembl
ENSMUSG00000022636
resolver
ensp
ENSMUSP00000023312
resolver
ensp
ENSMUSP00000129714
resolver
enst
ENSMUST00000023312
resolver
enst
ENSMUST00000170035
resolver
genesymbol
Alcam
resolver
genesymbol_syn
musc
resolver
uniprot
E9Q3Q6
resolver
uniprot
O70136
resolver
uniprot
Q3TTY3
resolver
uniprot
Q54AJ5
resolver
uniprot
Q8CDA5
resolver
uniprot
Q8R2T0
resolver
uniprot_entry
CD166_MOUSE
resolver
uniprot_entry
E9Q3Q6_MOUSE
resolver
uniprot_entry
Q3TTY3_MOUSE
resolver
uniprot_entry
Q54AJ5_MOUSE
resolver
uniprot_sec
O70136
resolver
uniprot_sec
Q8CDA5
resolver
uniprot_sec
Q8R2T0
resolver
amino_acid_sequence
MASKVSPSCRLVFCLLISAAVLRPGLGWYTVNSAYGDTIVMPCRLDVPQNLMFGKWKYEKPDGSPVFIAFRSSTKKSVQYDDVPEYKDRLSLSENYTLSIANAKISDEKRFVCMLVTEDNVFEAPTLVKVFKQPSKPEIVNKAPFLETDQLKKLGDCISRDSYPDGNITWYRNGKVLQPVEGEVAILFKKEIDPGTQLYTVTSSLEYKTTRSDIQMPFTCSVTYYGPSGQKTIYSEQEIFDIYYPTEQVTIQVLPPKNAIKEGDNITLQCLGNGNPPPEEFMFYLPGQPEGIRSSNTYTLTDVRRNATGDYKCSLIDKRNMAASTTITVHYLDLSLNPSGEVTKQIGDTLPVSCTISASRNATVVWMKDNIRLRSSPSFSSLHYQDAGNYVCETALQEVEGLKKRESLTLIVEGKPQIKMTKKTDPSGLSKTIICHVEGFPKPAIHWTITGSGSVINQTEESPYINGRYYSKIIISPEENVTLTCTAENQLERTVNSLNVSAISIPEHDEADDISDENREKVNDQAKLIVGIVVGLLLAALVAGVVYWLYMKKSKTASKHVNKDLGNMEENKKLEENNHKTEA
uniprot
proteins
function
FUNCTION: Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts. Promotes T-cell activation and proliferation via its interactions with CD6 (By similarity). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (By similarity). Mediates homotypic interactions with cells that express ALCAM (PubMed:24740813). Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction. Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions (PubMed:23169771). Required for normal organization of the lymph vessel network (PubMed:23169771). Required for normal hematopoietic stem cell engraftment in the bone marrow (PubMed:24740813). Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow (PubMed:25730656). Promotes in vitro osteoblast proliferation and differentiation (PubMed:25730656). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM (By similarity). Mediates outgrowth and pathfinding for retinal ganglion cell axons (PubMed:15345243). {ECO:0000250|UniProtKB:P42292, ECO:0000250|UniProtKB:Q13740, ECO:0000269|PubMed:15345243, ECO:0000269|PubMed:23169771}.
uniprot
proteins
mass_dalton
65092
uniprot
proteins
post_translational_modification
PTM: Glycosylated. {ECO:0000250|UniProtKB:Q13740}.
uniprot
proteins
pubmed
15345243
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16914752
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23169771
uniprot
proteins
pubmed
24740813
uniprot
proteins
pubmed
25730656
uniprot
proteins
pubmed
8089660
uniprot
proteins
pubmed
9209500
uniprot
proteins
sequence_length
583
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15345243, ECO:0000269|PubMed:16914752, ECO:0000269|PubMed:23169771, ECO:0000269|PubMed:9209500}; Single-pass type I membrane protein {ECO:0000305}. Cell projection, axon {ECO:0000269|PubMed:15345243}. Cell projection, dendrite {ECO:0000269|PubMed:15345243}. Note=Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells. Colocalizes with CD6 and the TCR/CD3 complex at the immunological synapse. {ECO:0000250|UniProtKB:Q13740}.
uniprot
proteins
transmembrane_region
TRANSMEM 528..549; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins