Ints15
entrez
231868
canonical
uniprot
Q8BGA7
canonical
ensembl
ENSMUSG00000039244
resolver
ensp
ENSMUSP00000041800
resolver
enst
ENSMUST00000046418
resolver
genesymbol
Ints15
resolver
uniprot
Q3T9D0
resolver
uniprot
Q8BN55
resolver
uniprot_entry
INT15_MOUSE
resolver
uniprot_sec
Q3T9D0
resolver
uniprot_sec
Q8BN55
resolver
amino_acid_sequence
MSDIRHSLLRRDALSAAKEVLYHLDIYFSSQLQSAPLPIVDKGSVELLEEFVFQVPKERGAQPKRLNSLQELQLLEIMCSYFQEQSKDSVRQIIFSSLFSPQGNKADDSRMSLLGKLVSMAVAVCRIPVLECAASWLQRTPVVYCVRLARVLVEDYCCLVPGSVQTLKQIFSASPRFCCQFITSVTALYDLSSDDLIPPLDLLEMIVSWIFEDPRLILITFLNTPIAANLPIGFLELTPLIGLIRWCVKAPLAYKRKKPCLSNGHISHKVAKDSGASTDRDSHLLYSKLHLSVLQVLMTLQLHLTEKNLYGRLGLILFDHMVPLVEEINRLADELNPLNASQEIELALDRLAQALQVAMTSGALLCTRDDLRTLCSRLPHNNLLQLVISGPVQQSPHTALPPGFYPHIHTPPLAYGAVPAHPAAHPALPTHPGHTFISGVTFPFRPIR
uniprot
proteins
function
FUNCTION: Component of the integrator complex, a multiprotein complex that terminates RNA polymerase II (Pol II) transcription in the promoter-proximal region of genes. The integrator complex provides a quality checkpoint during transcription elongation by driving premature transcription termination of transcripts that are unfavorably configured for transcriptional elongation: the complex terminates transcription by (1) catalyzing dephosphorylation of the C-terminal domain (CTD) of Pol II subunit POLR2A/RPB1 and SUPT5H/SPT5, (2) degrading the exiting nascent RNA transcript via endonuclease activity and (3) promoting the release of Pol II from bound DNA. The integrator complex is also involved in terminating the synthesis of non-coding Pol II transcripts, such as enhancer RNAs (eRNAs), small nuclear RNAs (snRNAs), telomerase RNAs and long non-coding RNAs (lncRNAs). INTS15 is part of the integrator tail module that acts as a platform for the recruitment of transcription factors at promoters. Within the integrator complex, INTS15 is required to bridge different integrator modules. {ECO:0000250|UniProtKB:Q96N11}.
uniprot
proteins
mass_dalton
49908
uniprot
proteins
protein_family
Integrator subunit 15 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
448
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q96N11}. Chromosome {ECO:0000250|UniProtKB:Q96N11}. Note=Associates to RNA polymerase II (Pol II) during active transcription. {ECO:0000250|UniProtKB:Q96N11}.
uniprot
proteins