TRPM1
entrez
4308
canonical
uniprot
Q7Z4N2
canonical
ensembl
ENSG00000134160
resolver
ensp
ENSP00000256552
resolver
ensp
ENSP00000380897
resolver
ensp
ENSP00000452946
resolver
ensp
ENSP00000453851
resolver
genesymbol
TRPM1
resolver
genesymbol_syn
LTRPC1
resolver
genesymbol_syn
MLSN
resolver
genesymbol_syn
MLSN1
resolver
hgnc
HGNC:7146
resolver
uniprot
D9IDV2
resolver
uniprot
D9IDV3
resolver
uniprot
F8W865
resolver
uniprot
H0YN37
resolver
uniprot
O75560
resolver
uniprot
Q6PE48
resolver
uniprot
Q7Z4N1
resolver
uniprot
Q7Z4N3
resolver
uniprot
Q7Z4N4
resolver
uniprot
Q7Z4N5
resolver
uniprot_entry
TRPM1_HUMAN
resolver
uniprot_sec
D9IDV2
resolver
uniprot_sec
D9IDV3
resolver
uniprot_sec
F8W865
resolver
uniprot_sec
H0YN37
resolver
uniprot_sec
O75560
resolver
uniprot_sec
Q6PE48
resolver
uniprot_sec
Q7Z4N1
resolver
uniprot_sec
Q7Z4N3
resolver
uniprot_sec
Q7Z4N4
resolver
uniprot_sec
Q7Z4N5
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by extracellular zinc ions (PubMed:21278253). Inhibited by intracellular Mg(2+) (PubMed:21278253). Activated by the neuroactive steroid pregnenolone sulfate (PubMed:21278253). Negatively regulated by activation of GRM6 receptors in the ON-bipolar cells (By similarity). {ECO:0000250|UniProtKB:Q2TV84, ECO:0000269|PubMed:21278253}.
uniprot
proteins
amino_acid_sequence
MKDSNRCCCGQFTNQHIPPLPSATPSKNEEESKQVETQPEKWSVAKHTQSYPTDSYGVLEFQGGGYSNKAMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQNFEMQPKLKQVFGKGLIKAAMTTGAWIFTGGVSTGVISHVGDALKDHSSKSRGRVCAIGIAPWGIVENKEDLVGKDVTRVYQTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRLLEKHISLQKINTRLGQGVPLVGLVVEGGPNVVSIVLEYLQEEPPIPVVICDGSGRASDILSFAHKYCEEGGIINESLREQLLVTIQKTFNYNKAQSHQLFAIIMECMKKKELVTVFRMGSEGQQDIEMAILTALLKGTNVSAPDQLSLALAWNRVDIARSQIFVFGPHWPPLGSLAPPTDSKATEKEKKPPMATTKGGRGKGKGKKKGKVKEEVEEETDPRKIELLNWVNALEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDVKKSNLPPDYHISLIDIGLVLEYLMGGAYRCNYTRKNFRTLYNNLFGPKRPKALKLLGMEDDEPPAKGKKKKKKKKEEEIDIDVDDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEESMAKALVACKLYKAMAHESSESDLVDDISQDLDNNSKDFGQLALELLDQSYKHDEQIAMKLLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILLPPTILFLEFRTYDDFSYQTSKENEDGKEKEEENTDANADAGSRKGDEENEHKKQRSIPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNYVILVRMDGWPSLQEWIVISYIVSLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAISTFMIGAILRLQNQPYMGYGRVIYCVDIIFWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINPPCGENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIILSHIYIIIMRLSGRCRKKREGDQEERDRGLKLFLSDEELKRLHEFEEQCVQEHFREKEDEQQSSSDERIRVTSERVENMSMRLEEINERETFMKTSLQTVDLRLAQLEELSNRMVNALENLAGIDRSDLIQARSRASSECEATYLLRQSSINSADGYSLYRYHFNGEELLFEDTSLSTSPGTGVRKKTCSFRIKEEKDVKTHLVPECQNSLHLSLGTSTSATPDGSHLAVDDLKNAEESKLGPDIGISKEDDERQTDSKKEETISPSLNKTDVIHGQDKSDVQNTQLTVETTNIEGTISYPLEETKITRYFPDETINACKTMKSRSFVYSRGRKLVGGVNQDVEYSSITDQQLTTEWQCQVQKITRSHSTDIPYIVSEAAVQAEHKEQFADMQDEHHVAEAIPRIPRLSLTITDRNGMENLLSVKPDQTLGFPSLRSKSLHGHPRNVKSIQGKLDRSGHASSVSSLVIVSGMTAEEKKVKKEKASTETEC
uniprot
proteins
disease_involvement
DISEASE: Night blindness, congenital stationary, 1C (CSNB1C) [MIM:613216]: A non-progressive retinal disorder characterized by impaired night vision, often associated with nystagmus and myopia. {ECO:0000269|PubMed:19878917, ECO:0000269|PubMed:19896109, ECO:0000269|PubMed:19896113}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Constitutively open nonselective divalent cation-conducting channels which mediate the influx of Ca(2+), Mg(2+), Mn(2+), Ba(2+), and Ni(2+) into the cytoplasm, leading to membrane depolarization (PubMed:11535825, PubMed:19436059, PubMed:21278253). Impermeable to zinc ions (PubMed:21278253). In addition, forms heteromultimeric ion channels with TRPM3 which are permeable for calcium and zinc ions (PubMed:21278253). Plays an essential role for the depolarizing photoresponse of retinal ON bipolar cells (PubMed:19878917, PubMed:19896109). In the dark, tonic release of glutamate activates the G protein-coupled receptor for glutamate, GRM6, its activation induces the release of G(o) protein and the beta-gamma G protein dimer. Both subunits can interact and inactivate the TRPM1 channel. A light onset, induces decrease in glutamate release and deactivation of GRM6 leading to channel opening and membrane depolarization (By similarity). May play a role in metastasis suppression (PubMed:9537257). {ECO:0000250|UniProtKB:Q2TV84, ECO:0000269|PubMed:11535825, ECO:0000269|PubMed:19436059, ECO:0000269|PubMed:19878917, ECO:0000269|PubMed:19896109, ECO:0000269|PubMed:21278253, ECO:0000269|PubMed:9537257}.
uniprot
proteins
mass_dalton
182178
uniprot
proteins
mutagenesis
MUTAGEN 989; /note="H->F: Reduces inhibition by zinc allowing zinc ion influx."; /evidence="ECO:0000269|PubMed:21278253"; MUTAGEN 1021..1027; /note="Missing: Abolishes inhibition by zinc allowing zinc ion influx."; /evidence="ECO:0000269|PubMed:21278253
uniprot
proteins
protein_family
LTrpC subfamily
uniprot
proteins
protein_family
TRPM1 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
pubmed
11112417
uniprot
proteins
pubmed
11535825
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
19436059
uniprot
proteins
pubmed
19878917
uniprot
proteins
pubmed
19896109
uniprot
proteins
pubmed
19896113
uniprot
proteins
pubmed
21278253
uniprot
proteins
pubmed
30027108
uniprot
proteins
pubmed
9537257
uniprot
proteins
pubmed
9806836
uniprot
proteins
sequence_length
1603
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11535825, ECO:0000269|PubMed:21278253}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:30027108}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000250|UniProtKB:Q2TV84}. Note=In ON-bipolar cells is intracellular and located predominantly in the ER, and not at the plasma membrane or Golgi apparatus. {ECO:0000269|PubMed:30027108}.
uniprot
proteins
transmembrane_region
TRANSMEM 831..851; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 898..918; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 929..949; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 962..982; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1055..1075; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1106..1126; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins