NAV2
entrez
89797
canonical
uniprot
Q8IVL1
canonical
ensembl
ENSG00000166833
resolver
ensp
ENSP00000309577
resolver
ensp
ENSP00000353871
resolver
ensp
ENSP00000379394
resolver
ensp
ENSP00000379396
resolver
ensp
ENSP00000437316
resolver
genesymbol
NAV2
resolver
genesymbol_syn
HELAD1
resolver
genesymbol_syn
KIAA1419
resolver
genesymbol_syn
POMFIL2
resolver
genesymbol_syn
RAINB1
resolver
genesymbol_syn
STEERIN2
resolver
hgnc
HGNC:15997
resolver
uniprot
A6NEC1
resolver
uniprot
A7E2D6
resolver
uniprot
Q8IVK3
resolver
uniprot
Q8IVK4
resolver
uniprot
Q8IVK5
resolver
uniprot
Q8IVK6
resolver
uniprot
Q8IVK7
resolver
uniprot
Q8IVK8
resolver
uniprot
Q8NHC9
resolver
uniprot
Q8NHD0
resolver
uniprot
Q8TDE9
resolver
uniprot
Q8TDF0
resolver
uniprot
Q8TEB3
resolver
uniprot
Q96B30
resolver
uniprot
Q9NUZ6
resolver
uniprot
Q9NVM7
resolver
uniprot
Q9P2C8
resolver
uniprot_entry
A7E2D6_HUMAN
resolver
uniprot_entry
NAV2_HUMAN
resolver
uniprot_sec
A6NEC1
resolver
uniprot_sec
Q8IVK3
resolver
uniprot_sec
Q8IVK4
resolver
uniprot_sec
Q8IVK5
resolver
uniprot_sec
Q8IVK6
resolver
uniprot_sec
Q8IVK7
resolver
uniprot_sec
Q8IVK8
resolver
uniprot_sec
Q8NHC9
resolver
uniprot_sec
Q8NHD0
resolver
uniprot_sec
Q8TDE9
resolver
uniprot_sec
Q8TDF0
resolver
uniprot_sec
Q8TEB3
resolver
uniprot_sec
Q96B30
resolver
uniprot_sec
Q9NUZ6
resolver
uniprot_sec
Q9NVM7
resolver
uniprot_sec
Q9P2C8
resolver
amino_acid_sequence
MPAILVASKMKSGLPKPVHSAAPILHVPPARAGPQPCYLKLGSKVEVSKTTYPSQIPLKSQVLQGLQEPAGEGLPLRKSGSVENGFDTQIYTDWANHYLAKSGHKRLIRDLQQDVTDGVLLAQIIQVVANEKIEDINGCPKNRSQMIENIDACLNFLAAKGINIQGLSAEEIRNGNLKAILGLFFSLSRYKQQQQQPQKQHLSSPLPPAVSQVAGAPSQCQAGTPQQQVPVTPQAPCQPHQPAPHQQSKAQAEMQSSASSKDSSQSKIIRFTLGQKKISRLPGPTARVSAAGSEAKTRGGSTTANNRRSQSFNNYDKSKPVTSPPPPPSSHEKEPLASSASSHPGMSDNAPASLESGSSSTPTNCSTSSAIPQPGAATKPWRSKSLSVKHSATVSMLSVKPPGPEAPRPTPEAMKPAPNNQKSMLEKLKLFNSKGGSKAGEGPGSRDTSCERLETLPSFEESEELEAASRMLTTVGPASSSPKIALKGIAQRTFSRALTNKKSSLKGNEKEKEKQQREKDKEKSKDLAKRASVTERLDLKEEPKEDPSGAAVPEMPKKSSKIASFIPKGGKLNSAKKEPMAPSHSGIPKPGMKSMPGKSPSAPAPSKEGERSRSGKLSSGLPQQKPQLDGRHSSSSSSLASSEGKGPGGTTLNHSISSQTVSGSVGTTQTTGSNTVSVQLPQPQQQYNHPNTATVAPFLYRSQTDTEGNVTAESSSTGVSVEPSHFTKTGQPALEELTGEDPEARRLRTVKNIADLRQNLEETMSSLRGTQVTHSTLETTFDTNVTTEMSGRSILSLTGRPTPLSWRLGQSSPRLQAGDAPSMGNGYPPRANASRFINTESGRYVYSAPLRRQLASRGSSVCHVDVSDKAGDEMDLEGISMDAPGYMSDGDVLSKNIRTDDITSGYMTDGGLGLYTRRLNRLPDGMAVVRETLQRNTSLGLGDADSWDDSSSVSSGISDTIDNLSTDDINTSSSISSYANTPASSRKNLDVQTDAEKHSQVERNSLWSGDDVKKSDGGSDSGIKMEPGSKWRRNPSDVSDESDKSTSGKKNPVISQTGSWRRGMTAQVGITMPRTKPSAPAGALKTPGTGKTDDAKVSEKGRLSPKASQVKRSPSDAGRSSGDESKKPLPSSSRTPTANANSFGFKKQSGSAAGLAMITASGVTVTSRSATLGKIPKSSALVSRSAGRKSSMDGAQNQDDGYLALSSRTNLQYRSLPRPSKSNSRNGAGNRSSTSSIDSNISSKSAGLPVPKLREPSKTALGSSLPGLVNQTDKEKGISSDNESVASCNSVKVNPAAQPVSSPAQTSLQPGAKYPDVASPTLRRLFGGKPTKQVPIATAENMKNSVVISNPHATMTQQGNLDSPSGSGVLSSGSSSPLYSKNVDLNQSPLASSPSSAHSAPSNSLTWGTNASSSSAVSKDGLGFQSVSSLHTSCESIDISLSSGGVPSHNSSTGLIASSKDDSLTPFVRTNSVKTTLSESPLSSPAASPKFCRSTLPRKQDSDPHLDRNTLPKKGLRYTPTSQLRTQEDAKEWLRSHSAGGLQDTAANSPFSSGSSVTSPSGTRFNFSQLASPTTVTQMSLSNPTMLRTHSLSNADGQYDPYTDSRFRNSSMSLDEKSRTMSRSGSFRDGFEEESWEKSSVDNFVSRLHSSLHFSLPLFHHARYELVHGSSLSLVSSTSSVYSTPEEKCQSEIRKLRRELDASQEKVSALTTQLTANAHLVAAFEQSLGNMTIRLQSLTMTAEQKDSELNELRKTIELLKKQNAAAQAAINGVINTPELNCKGNGTAQSADLRIRRQHSSDSVSSINSATSHSSVGSNIESDSKKKKRKNWVNELRSSFKQAFGKKKSPKSASSHSDIEEMTDSSLPSSPKLPHNGSTGSTPLLRNSHSNSLISECMDSEAETVMQLRNELRDKEMKLTDIRLEALSSAHQLDQLREAMNRMQSEIEKLKAENDRLKSESQGSGCSRAPSQVSISASPRQSMGLSQHSLNLTESTSLDMLLDDTGECSARKEGGRHVKIVVSFQEEMKWKEDSRPHLFLIGCIGVSGKTKWDVLDGVVRRLFKEYIIHVDPVSQLGLNSDSVLGYSIGEIKRSNTSETPELLPCGYLVGENTTISVTVKGLAENSLDSLVFESLIPKPILQRYVSLLIEHRRIILSGPSGTGKTYLANRLSEYIVLREGRELTDGVIATFNVDHKSSKELRQYLSNLADQCNSENNAVDMPLVIILDNLHHVSSLGEIFNGLLNCKYHKCPYIIGTMNQATSSTPNLQLHHNFRWVLCANHTEPVKGFLGRFLRRKLMETEISGRVRNMELVKIIDWIPKVWHHLNRFLEAHSSSDVTIGPRLFLSCPIDVDGSRVWFTDLWNYSIIPYLLEAVREGLQLYGRRAPWEDPAKWVMDTYPWAASPQQHEWPPLLQLRPEDVGFDGYSMPREGSTSKQMPPSDAEGDPLMNMLMRLQEAANYSSPQSYDSDSNSNSHHDDILDSSLESTL
uniprot
proteins
ec_number
3.6.4.12
uniprot
proteins
function
FUNCTION: Possesses 3' to 5' helicase activity and exonuclease activity (PubMed:12214280, PubMed:15158073). Involved in cytoskeleton organization (PubMed:35218524). Required for neurite outgrowth in response to stimulation by all-trans retinoic acid (atRA) (PubMed:18726912). Involved in neuronal development, specifically in the development of different sensory organs (PubMed:12214280, PubMed:15158073). Important for brain and cerebellar development (PubMed:35218524). Involved in the differentiation, migration and axonal extension of granule cells in the developing cerebellum (By similarity). Involved in the development of the glossopharyngeal cranial nerve IX and the vagus cranial nerve X, possibly by influencing neuronal cell elongation or survival; influencing the efficiency of the baroreceptor reflex response to changes in blood pressure (By similarity). {ECO:0000250|UniProtKB:V9GX91, ECO:0000269|PubMed:12214280, ECO:0000269|PubMed:15158073, ECO:0000269|PubMed:18726912, ECO:0000269|PubMed:35218524}.
uniprot
proteins
mass_dalton
268167
uniprot
proteins
protein_family
Nav/unc-53 family
uniprot
proteins
pubmed
10718198
uniprot
proteins
pubmed
11904404
uniprot
proteins
pubmed
12062803
uniprot
proteins
pubmed
12079279
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
12214280
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15158073
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18726912
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
35218524
uniprot
proteins
sequence_length
2488
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12214280}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:18726912}. Cell projection, axon {ECO:0000269|PubMed:18726912}. Perikaryon {ECO:0000269|PubMed:18726912}. Note=Colocalizes with neurofilaments in the perikaryon and the neurites/axons of neuronal cells (PubMed:18726912). Partially colocalizes in a punctate fashion along the length of microtubules (PubMed:18726912). {ECO:0000269|PubMed:18726912}.
uniprot
proteins