Padi6
entrez
242726
canonical
uniprot
Q8K3V4
canonical
ensembl
ENSMUSG00000040935
resolver
ensp
ENSMUSP00000044044
resolver
enst
ENSMUST00000038749
resolver
genesymbol
Padi6
resolver
genesymbol_syn
Pad6
resolver
genesymbol_syn
Padi5
resolver
uniprot
Q75WC6
resolver
uniprot_entry
PADI6_MOUSE
resolver
uniprot_sec
Q75WC6
resolver
amino_acid_sequence
MSFQNSLSLSLVNPTHALCMVGMEITLDISKCAPDKCKSFTIRGSPRILIHISSSVIAGKEDTVVWRSMNHPTVALVRMVAPSPTVDEDKVLVSYFCPDQEVPTATAVLFLTGIEISLEADIYRDGQLDMPSDKQAKKKWMWGMNGWGAILLVNCSPNAVGQPDEQSFQEGPREIQNLSQMNVTVEGPTSILQNYQLILHTSEEEAKKTRVYWSQRGSSAYELVVGPNKPVYLLPTFENRRKEAFYVEATEFPSPSFSGLISLSLSLVEKAHDECIPEIPLYKDTVMFRVAPYIFMPSTQMPLEVYLCRELQLQGFVDSVTKLSEKSKVQVVKVYEDPNRQSKWLQDEMAFCYTQAPHKTVSLILDTPRVSKLEDFPMKYTLTPGSGYLIRQTEDHRVASLDSIGNLMVSPPVKAQGKDYPLGRVLIGGSFYPSSEGRDMNKGLREFVYAQQVQAPVELFSDWLMTGHMDQFMCFVPTNDKNNDQKDFRLLLASPSACFELFEQKQKEGYGNVTLFEDIGAEQLLSNGRESKTISQILADKSFREQNTYVEKCISLNRTLLKTELGLEDKDIILIPQLFCLEQLTNVPSNQQSTKLFARPYFPDMLQIIVLGKNLGIPKPFGPKINGTCCLEEKVCGLLEPLGLKCTFIDDFDCYLANIGDVCASAIINRVPFAFKWWKMTP
uniprot
proteins
function
FUNCTION: Structural constituent of cytoplasmic lattices, which plays a key role in early embryonic development (PubMed:16137333, PubMed:17587491, PubMed:18599511, PubMed:27929740, PubMed:37922900, PubMed:38453481, PubMed:41772195, PubMed:41845018, PubMed:41917274, PubMed:41986725). Cytoplasmic lattices consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos: they are required to store maternal proteins critical for embryonic development, such as ribosomal proteins, cytoskeletal tubulins and proteins controlling epigenetic reprogramming of the preimplantation embryo, in a poised but restrained state, regulating their availability for early embryonic development (PubMed:18599511, PubMed:21147087, PubMed:37922900, PubMed:38453481, PubMed:41845018, PubMed:41917274, PubMed:41986725, PubMed:41998711). Cytoplasmic lattices also tightly control ubiquitination during the oocyte-to-embryo transition by trapping E3 ubiquitin-protein ligase UHRF1 in a compact autoinhibited conformation and maintaining SCF ubiquitin ligase complexes inactive (PubMed:41845018, PubMed:41917274, PubMed:41986725). PADI6 oligomers acts as an essential structural scaffolding element of cytoplasmic lattices (PubMed:41845018, PubMed:41917274, PubMed:41986725). In contrast to other members of the family, does not show protein-arginine deiminase activity due to its inability to bind Ca(2+) (By similarity). {ECO:0000250|UniProtKB:Q6TGC4, ECO:0000269|PubMed:16137333, ECO:0000269|PubMed:17587491, ECO:0000269|PubMed:18599511, ECO:0000269|PubMed:21147087, ECO:0000269|PubMed:27929740, ECO:0000269|PubMed:37922900, ECO:0000269|PubMed:38453481, ECO:0000269|PubMed:41772195, ECO:0000269|PubMed:41845018, ECO:0000269|PubMed:41917274, ECO:0000269|PubMed:41986725, ECO:0000269|PubMed:41998711}.
uniprot
proteins
mass_dalton
76778
uniprot
proteins
mutagenesis
MUTAGEN 620; /note="P->A: Embryos of female knockin mice stop development at the two-cell stage. Mutant oocytes display defects of epigenetic reprogramming and zygotic genome activation. Embryos that overcome the two-cell stage block display a dramatic reduction in UHRF1 and DNMT1 protein levels, a decrease in H3K9me3, and whole-genome hypomethylation."; /evidence="ECO:0000269|PubMed:38453481, ECO:0000269|PubMed:41998711
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-2, possibly by RSK-type kinases, and Ser-434 creates binding sites for 14-3-3 proteins. {ECO:0000250|UniProtKB:Q6TGC4}.
uniprot
proteins
protein_family
Protein arginine deiminase family
uniprot
proteins
pubmed
12654293
uniprot
proteins
pubmed
15087120
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16137333
uniprot
proteins
pubmed
17587491
uniprot
proteins
pubmed
18599511
uniprot
proteins
pubmed
21147087
uniprot
proteins
pubmed
27929740
uniprot
proteins
pubmed
37922900
uniprot
proteins
pubmed
38453481
uniprot
proteins
pubmed
41772195
uniprot
proteins
pubmed
41845018
uniprot
proteins
pubmed
41917274
uniprot
proteins
pubmed
41986725
uniprot
proteins
pubmed
41998711
uniprot
proteins
sequence_length
682
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12654293, ECO:0000269|PubMed:18599511, ECO:0000269|PubMed:21147087, ECO:0000269|PubMed:27929740, ECO:0000269|PubMed:37922900, ECO:0000269|PubMed:38453481}. Nucleus {ECO:0000269|PubMed:12654293}. Cytoplasmic vesicle, secretory vesicle, Cortical granule {ECO:0000269|PubMed:16137333}. Note=Core component of cytoplasmic lattices in oocytes (PubMed:18599511, PubMed:21147087, PubMed:27929740, PubMed:37922900). Also nuclear (PubMed:16137333). {ECO:0000269|PubMed:16137333, ECO:0000269|PubMed:18599511, ECO:0000269|PubMed:21147087, ECO:0000269|PubMed:27929740, ECO:0000269|PubMed:37922900}.
uniprot
proteins