A4GALT
entrez
53947
canonical
uniprot
Q9NPC4
canonical
ensembl
ENSG00000128274
resolver
ensp
ENSP00000249005
resolver
ensp
ENSP00000370678
resolver
ensp
ENSP00000384794
resolver
ensp
ENSP00000494127
resolver
ensp
ENSP00000538316
resolver
ensp
ENSP00000538317
resolver
ensp
ENSP00000538318
resolver
ensp
ENSP00000538319
resolver
ensp
ENSP00000538320
resolver
ensp
ENSP00000538321
resolver
ensp
ENSP00000538322
resolver
ensp
ENSP00000538323
resolver
ensp
ENSP00000538324
resolver
ensp
ENSP00000538325
resolver
ensp
ENSP00000538326
resolver
ensp
ENSP00000538327
resolver
ensp
ENSP00000538328
resolver
ensp
ENSP00000538329
resolver
ensp
ENSP00000538330
resolver
ensp
ENSP00000538331
resolver
ensp
ENSP00000538332
resolver
ensp
ENSP00000538333
resolver
ensp
ENSP00000538334
resolver
ensp
ENSP00000538335
resolver
ensp
ENSP00000538336
resolver
ensp
ENSP00000538337
resolver
ensp
ENSP00000538338
resolver
ensp
ENSP00000538339
resolver
ensp
ENSP00000538340
resolver
ensp
ENSP00000582697
resolver
ensp
ENSP00000629752
resolver
ensp
ENSP00000629753
resolver
ensp
ENSP00000629754
resolver
ensp
ENSP00000629755
resolver
ensp
ENSP00000629756
resolver
ensp
ENSP00000629757
resolver
ensp
ENSP00000629758
resolver
ensp
ENSP00000629759
resolver
ensp
ENSP00000629760
resolver
ensp
ENSP00000629761
resolver
ensp
ENSP00000629762
resolver
ensp
ENSP00000629763
resolver
ensp
ENSP00000629764
resolver
ensp
ENSP00000629765
resolver
ensp
ENSP00000629766
resolver
ensp
ENSP00000629767
resolver
ensp
ENSP00000629768
resolver
ensp
ENSP00000629769
resolver
ensp
ENSP00000629770
resolver
ensp
ENSP00000629771
resolver
ensp
ENSP00000629772
resolver
ensp
ENSP00000629773
resolver
enst
ENST00000249005
resolver
enst
ENST00000381278
resolver
enst
ENST00000401850
resolver
enst
ENST00000642412
resolver
enst
ENST00000868257
resolver
enst
ENST00000868258
resolver
enst
ENST00000868259
resolver
enst
ENST00000868260
resolver
enst
ENST00000868261
resolver
enst
ENST00000868262
resolver
enst
ENST00000868263
resolver
enst
ENST00000868264
resolver
enst
ENST00000868265
resolver
enst
ENST00000868266
resolver
enst
ENST00000868267
resolver
enst
ENST00000868268
resolver
enst
ENST00000868269
resolver
enst
ENST00000868270
resolver
enst
ENST00000868271
resolver
enst
ENST00000868272
resolver
enst
ENST00000868273
resolver
enst
ENST00000868274
resolver
enst
ENST00000868275
resolver
enst
ENST00000868276
resolver
enst
ENST00000868277
resolver
enst
ENST00000868278
resolver
enst
ENST00000868279
resolver
enst
ENST00000868280
resolver
enst
ENST00000868281
resolver
enst
ENST00000912638
resolver
enst
ENST00000959693
resolver
enst
ENST00000959694
resolver
enst
ENST00000959695
resolver
enst
ENST00000959696
resolver
enst
ENST00000959697
resolver
enst
ENST00000959698
resolver
enst
ENST00000959699
resolver
enst
ENST00000959700
resolver
enst
ENST00000959701
resolver
enst
ENST00000959702
resolver
enst
ENST00000959703
resolver
enst
ENST00000959704
resolver
enst
ENST00000959705
resolver
enst
ENST00000959706
resolver
enst
ENST00000959707
resolver
enst
ENST00000959708
resolver
enst
ENST00000959709
resolver
enst
ENST00000959710
resolver
enst
ENST00000959711
resolver
enst
ENST00000959712
resolver
enst
ENST00000959713
resolver
enst
ENST00000959714
resolver
genesymbol
A4GALT
resolver
genesymbol_syn
A14GALT
resolver
genesymbol_syn
A4GALT1
resolver
hgnc
HGNC:18149
resolver
uniprot
A0A0S2Z5J1
resolver
uniprot
B2R7C4
resolver
uniprot
Q5D079
resolver
uniprot
Q9P1X5
resolver
uniprot_entry
A0A0S2Z5J1_HUMAN
resolver
uniprot_entry
A4GAT_HUMAN
resolver
uniprot_entry
Q5D079_HUMAN
resolver
uniprot_sec
B2R7C4
resolver
uniprot_sec
Q9P1X5
resolver
amino_acid_sequence
MSKPPDLLLRLLRGAPRQRVCTLFIIGFKFTFFVSIMIYWHVVGEPKEKGQLYNLPAEIPCPTLTPPTPPSHGPTPGNIFFLETSDRTNPNFLFMCSVESAARTHPESHVLVLMKGLPGGNASLPRHLGISLLSCFPNVQMLPLDLRELFRDTPLADWYAAVQGRWEPYLLPVLSDASRIALMWKFGGIYLDTDFIVLKNLRNLTNVLGTQSRYVLNGAFLAFERRHEFMALCMRDFVDHYNGWIWGHQGPQLLTRVFKKWCSIRSLAESRACRGVTTLPPEAFYPIPWQDWKKYFEDINPEELPRLLSATYAVHVWNKKSQGTRFEATSRALLAQLHARYCPTTHEAMKMYL
uniprot
proteins
ec_number
2.4.1.228
uniprot
proteins
function
FUNCTION: Glycosyltransferase involved in biosynthesis of P1, P(k) and the rare NOR antigens of P1PK histo-blood group system (PubMed:10747952, PubMed:10748143, PubMed:22965229, PubMed:26773500, PubMed:29572228, PubMed:33460651). Catalyzes the transfer of galactose from UDP-alpha-D-galactose in an alpha1,4 linkage to lactosylceramide/beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide(d18:1(4E)) to produce globotriaosylceramide/globoside Gb3Cer (d18:1(4E)), also known as P(k) antigen or CD77 (PubMed:10748143, PubMed:10747952, PubMed:26773500, PubMed:29572228, PubMed:22965229). Globoside Gb3Cer/P(k)/CD77 is a root structure in biosynthesis pathway of neutral glycosphingolipids of the globo-series. Broadly expressed in cell membranes of immune cells and other tissues, Gb3Cer/P(k)/CD77 antigen may participate in mechanisms that regulate cell-cell interactions and cell differentiation. In germinal center B cells, Gb3Cer/CD77 interacts with CD19 to drive centroblast-to-centrocyte transition, B cell receptor complex assembly and T follicular helper cell differentiation. In epithelium, Gb3Cer regulates CDH1/E-cadherin-dependent cell-cell adhesion counteracting epithelial-to-mesenchymal transition (By similarity) (PubMed:29572228). Synthesizes P1 glycan epitope (alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-GlcNAc-R) by transferring a galactose moiety to paragloboside nLc4 or to complex-type N-glycans (PubMed:26773500, PubMed:29572228, PubMed:33460651). Generates the rare NOR1 and NOR2 antigens which carry a Gal(alpha1->4)GalNAc terminal moiety and are both derived from Gb4Cer precursor (PubMed:22965229, PubMed:26773500, PubMed:33460651). Also able to transfer galactose to galactosylceramide/beta-D-Gal-(1<->1')-Cer (PubMed:10748143). {ECO:0000250|UniProtKB:Q67BJ4, ECO:0000269|PubMed:10747952, ECO:0000269|PubMed:10748143, ECO:0000269|PubMed:22965229, ECO:0000269|PubMed:26773500, ECO:0000269|PubMed:29572228, ECO:0000269|PubMed:33460651}.; FUNCTION: (Microbial infection) P1 and Pk antigens are targeted by Shiga toxins (also called verotoxins), as a way to enter the cell, inhibit protein synthesis and induce apoptosis. {ECO:0000269|PubMed:10748143, ECO:0000269|PubMed:33460651}.
uniprot
proteins
mass_dalton
40499
uniprot
proteins
mutagenesis
MUTAGEN 194; /note="D->A: Abolishes Gb3Cer/P(k) and P1 antigen expression."; /evidence="ECO:0000269|PubMed:29572228
uniprot
proteins
pathway_participation
PATHWAY: Glycolipid biosynthesis. {ECO:0000305|PubMed:10748143, ECO:0000305|PubMed:22965229, ECO:0000305|PubMed:26773500, ECO:0000305|PubMed:29572228}.; PATHWAY: Protein modification; protein glycosylation. {ECO:0000305|PubMed:33460651}.
uniprot
proteins
protein_family
Glycosyltransferase 32 family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
10747952
uniprot
proteins
pubmed
10748143
uniprot
proteins
pubmed
10993874
uniprot
proteins
pubmed
11896312
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15014171
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22965229
uniprot
proteins
pubmed
26773500
uniprot
proteins
pubmed
29572228
uniprot
proteins
pubmed
33460651
uniprot
proteins
sequence_length
353
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..43; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins