GMPS
entrez
8833
canonical
uniprot
P49915
canonical
ensembl
ENSG00000163655
resolver
ensp
ENSP00000295920
resolver
ensp
ENSP00000419851
resolver
genesymbol
GMPS
resolver
hgnc
HGNC:4378
resolver
uniprot
A0A140VJK6
resolver
uniprot
A8K639
resolver
uniprot
B4DXV7
resolver
uniprot
F8W720
resolver
uniprot_entry
A0A140VJK6_HUMAN
resolver
uniprot_entry
GUAA_HUMAN
resolver
uniprot_sec
A8K639
resolver
uniprot_sec
B4DXV7
resolver
uniprot_sec
F8W720
resolver
amino_acid_sequence
MALCNGDSKLENAGGDLKDGHHHYEGAVVILDAGAQYGKVIDRRVRELFVQSEIFPLETPAFAIKEQGFRAIIISGGPNSVYAEDAPWFDPAIFTIGKPVLGICYGMQMMNKVFGGTVHKKSVREDGVFNISVDNTCSLFRGLQKEEVVLLTHGDSVDKVADGFKVVARSGNIVAGIANESKKLYGAQFHPEVGLTENGKVILKNFLYDIAGCSGTFTVQNRELECIREIKERVGTSKVLVLLSGGVDSTVCTALLNRALNQEQVIAVHIDNGFMRKRESQSVEEALKKLGIQVKVINAAHSFYNGTTTLPISDEDRTPRKRISKTLNMTTSPEEKRKIIGDTFVKIANEVIGEMNLKPEEVFLAQGTLRPDLIESASLVASGKAELIKTHHNDTELIRKLREEGKVIEPLKDFHKDEVRILGRELGLPEELVSRHPFPGPGLAIRVICAEEPYICKDFPETNNILKIVADFSASVKKPHTLLQRVKACTTEEDQEKLMQITSLHSLNAFLLPIKTVGVQGDCRSYSYVCGISSKDEPDWESLIFLARLIPRMCHNVNRVVYIFGPPVKEPPTDVTPTFLTTGVLSTLRQADFEAHNILRESGYAGKISQMPVILTPLHFDRDPLQKQPSCQRSVVIRTFITSDFMTGIPATPGNEIPVEVVLKMVTEIKKIPGISRIMYDLTSKPPGTTEWE
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving GMPS is found in acute myeloid leukemias. Translocation t(3,11)(q25,q23) with KMT2A/MLL1.
uniprot
proteins
ec_number
6.3.5.2
uniprot
proteins
function
FUNCTION: Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate. {ECO:0000269|PubMed:8089153}.
uniprot
proteins
mass_dalton
76715
uniprot
proteins
pathway_participation
PATHWAY: Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.
uniprot
proteins
pubmed
11110714
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23816837
uniprot
proteins
pubmed
8089153
uniprot
proteins
sequence_length
693
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:8089153}.
uniprot
proteins