Nup62
entrez
65274
canonical
uniprot
P17955
canonical
ensembl
ENSRNOG00000048733
resolver
ensembl
ENSRNOG00055005582
resolver
ensembl
ENSRNOG00060007475
resolver
ensembl
ENSRNOG00065028283
resolver
ensp
ENSRNOP00000027320
resolver
ensp
ENSRNOP00000067556
resolver
ensp
ENSRNOP00000081212
resolver
ensp
ENSRNOP00000099569
resolver
ensp
ENSRNOP00000100099
resolver
ensp
ENSRNOP00000103649
resolver
ensp
ENSRNOP00000103918
resolver
ensp
ENSRNOP00000112754
resolver
ensp
ENSRNOP00055006837
resolver
ensp
ENSRNOP00055006838
resolver
ensp
ENSRNOP00060009314
resolver
ensp
ENSRNOP00060009317
resolver
ensp
ENSRNOP00065039949
resolver
ensp
ENSRNOP00065039951
resolver
enst
ENSRNOT00000027320
resolver
enst
ENSRNOT00000074847
resolver
enst
ENSRNOT00000117253
resolver
enst
ENSRNOT00000123208
resolver
enst
ENSRNOT00000126621
resolver
enst
ENSRNOT00000132591
resolver
enst
ENSRNOT00000138345
resolver
enst
ENSRNOT00000155881
resolver
enst
ENSRNOT00055008973
resolver
enst
ENSRNOT00055008974
resolver
enst
ENSRNOT00060012310
resolver
enst
ENSRNOT00060012314
resolver
enst
ENSRNOT00065048717
resolver
enst
ENSRNOT00065048719
resolver
genesymbol
Nup62
resolver
uniprot
A2VCW0
resolver
uniprot_entry
NUP62_RAT
resolver
uniprot_sec
A2VCW0
resolver
amino_acid_sequence
MSGFNFGGTGAPAGGFTFGTAKTATTTPATGFSFSASGTGTGGFNFGTPSQPAATTPSTSLFSLATQTSTTQTPGFNFGTTPASGGTGFSLGISTPKLSLSSTAATPATANTGSFGLGSSTLTNAISGASTSSQGTAPTGFVFGSSTTSAPSTGTTGFSFTSGSASQPGASGFNIGSVGSLAQPTALSGSPFTPATLATTTAGATQPAAATPTAATTSAGSTLFASIAAAPASSSTTVLSLSAPATTAATPTAGTLGFSLKAPGAAPGASTTSTTTTTTTTTTTASTSSSTTTTGFALSLKPLVPAGPSSVAATALPASSTAVGTTTGPAMTYAQLESLINKWSLELEDQERHFLQQATQVNAWDRTLIENGEKITSLHREVEKVKLDQKRLDQELDFILSQQKELEDLLSPLEESVKEQSGTIYLQHADEEREKTYKLAENIDAQLKRMAQDLKDIIEHLNMAGGPADTSDPLQQICKILNAHMDSLQWVDQSSALLQRRVEEASRVCESRRKEQERSLRIAFD
uniprot
proteins
function
FUNCTION: Essential component of the nuclear pore complex (PubMed:2190987, PubMed:8707840). The N-terminal is probably involved in nucleocytoplasmic transport (By similarity). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of p62 to the pore complex (By similarity). Plays a role in mitotic cell cycle progression by regulating centrosome segregation, centriole maturation and spindle orientation (By similarity). It might be involved in protein recruitment to the centrosome after nuclear breakdown (By similarity). {ECO:0000250|UniProtKB:P37198, ECO:0000269|PubMed:2190987, ECO:0000269|PubMed:8707840}.
uniprot
proteins
mass_dalton
53397
uniprot
proteins
post_translational_modification
PTM: The inner channel of the NPC has a different redox environment from the cytoplasm and allows the formation of interchain disulfide bonds between some nucleoporins, the significant increase of these linkages upon oxidative stress reduces the permeability of the NPC. {ECO:0000250}.
uniprot
proteins
protein_family
Nucleoporin NSP1/NUP62 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
2050692
uniprot
proteins
pubmed
2190987
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
3200844
uniprot
proteins
pubmed
8707840
uniprot
proteins
sequence_length
525
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nuclear pore complex {ECO:0000269|PubMed:8707840}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:P37198}. Nucleus envelope {ECO:0000269|PubMed:2190987}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:P37198}. Note=Central region of the nuclear pore, within the transporter. During mitotic cell division, it associates with the poles of the mitotic spindle. {ECO:0000250|UniProtKB:P37198}.
uniprot
proteins