DLG1
entrez
1739
canonical
uniprot
Q12959
canonical
ensembl
ENSG00000075711
resolver
ensp
ENSP00000345731
resolver
ensp
ENSP00000350303
resolver
ensp
ENSP00000376186
resolver
ensp
ENSP00000391732
resolver
ensp
ENSP00000396658
resolver
ensp
ENSP00000398939
resolver
ensp
ENSP00000407531
resolver
ensp
ENSP00000413238
resolver
ensp
ENSP00000499229
resolver
ensp
ENSP00000499269
resolver
ensp
ENSP00000499280
resolver
ensp
ENSP00000499313
resolver
ensp
ENSP00000499363
resolver
ensp
ENSP00000499413
resolver
ensp
ENSP00000499414
resolver
ensp
ENSP00000499437
resolver
ensp
ENSP00000499440
resolver
ensp
ENSP00000499507
resolver
ensp
ENSP00000499514
resolver
ensp
ENSP00000499542
resolver
ensp
ENSP00000499580
resolver
ensp
ENSP00000499584
resolver
ensp
ENSP00000499599
resolver
ensp
ENSP00000499602
resolver
ensp
ENSP00000499657
resolver
ensp
ENSP00000499692
resolver
ensp
ENSP00000499723
resolver
ensp
ENSP00000499774
resolver
ensp
ENSP00000499793
resolver
ensp
ENSP00000557966
resolver
ensp
ENSP00000557967
resolver
ensp
ENSP00000557969
resolver
ensp
ENSP00000557970
resolver
ensp
ENSP00000588349
resolver
ensp
ENSP00000588350
resolver
ensp
ENSP00000588351
resolver
ensp
ENSP00000588352
resolver
ensp
ENSP00000588353
resolver
ensp
ENSP00000588354
resolver
ensp
ENSP00000588355
resolver
ensp
ENSP00000588356
resolver
ensp
ENSP00000588357
resolver
ensp
ENSP00000588358
resolver
ensp
ENSP00000618548
resolver
ensp
ENSP00000618550
resolver
enst
ENST00000653795
resolver
enst
ENST00000656087
resolver
enst
ENST00000656944
resolver
enst
ENST00000657381
resolver
enst
ENST00000659221
resolver
enst
ENST00000660898
resolver
enst
ENST00000661013
resolver
enst
ENST00000661336
resolver
enst
ENST00000662727
resolver
enst
ENST00000667104
resolver
enst
ENST00000671246
resolver
enst
ENST00000887907
resolver
enst
ENST00000887910
resolver
enst
ENST00000887911
resolver
enst
ENST00000918291
resolver
enst
ENST00000918292
resolver
enst
ENST00000918293
resolver
enst
ENST00000918294
resolver
enst
ENST00000918295
resolver
enst
ENST00000918297
resolver
enst
ENST00000918298
resolver
enst
ENST00000948491
resolver
genesymbol
DLG1
resolver
hgnc
HGNC:2900
resolver
uniprot
A0A0C4DFT3
resolver
uniprot
A0A590UJ08
resolver
uniprot
A0A590UJ68
resolver
uniprot
A0A590UJD9
resolver
uniprot
A0A590UJX2
resolver
uniprot
A0A590UK48
resolver
uniprot
A0A590UKA8
resolver
uniprot
A5YKK7
resolver
uniprot
B4DF78
resolver
uniprot
B4DGU1
resolver
uniprot
B4DGZ8
resolver
uniprot
B7ZMM0
resolver
uniprot
B9EIQ5
resolver
uniprot
D3DXB8
resolver
uniprot
D3DXB9
resolver
uniprot
E7EWL7
resolver
uniprot
E9PG21
resolver
uniprot
Q12958
resolver
uniprot_entry
A0A0C4DFT3_HUMAN
resolver
uniprot_entry
A0A590UJ08_HUMAN
resolver
uniprot_entry
A0A590UJ68_HUMAN
resolver
uniprot_entry
A0A590UJD9_HUMAN
resolver
uniprot_entry
A0A590UJX2_HUMAN
resolver
uniprot_entry
A0A590UK48_HUMAN
resolver
uniprot_entry
A0A590UKA8_HUMAN
resolver
uniprot_entry
B4DF78_HUMAN
resolver
uniprot_entry
DLG1_HUMAN
resolver
uniprot_sec
A5YKK7
resolver
uniprot_sec
B4DGU1
resolver
uniprot_sec
B4DGZ8
resolver
uniprot_sec
B7ZMM0
resolver
uniprot_sec
B9EIQ5
resolver
uniprot_sec
D3DXB8
resolver
uniprot_sec
D3DXB9
resolver
uniprot_sec
E7EWL7
resolver
uniprot_sec
E9PG21
resolver
uniprot_sec
Q12958
resolver
amino_acid_sequence
MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTLLDNPKCIDRSKPSEPIQPVNTWEISSLPSSTVTSETLPSSLSPSVEKYRYQDEDTPPQEHISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVLPSPPTVPVIPVLPVPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPAKEKL
uniprot
proteins
function
FUNCTION: Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. Promotes epithelial cell layer barrier function via maintaining cell-cell adhesion (By similarity). May also play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel. During long-term depression in hippocampal neurons, it recruits ADAM10 to the plasma membrane (PubMed:23676497). {ECO:0000250|UniProtKB:A0A8C0TYJ0, ECO:0000250|UniProtKB:Q811D0, ECO:0000269|PubMed:10656683, ECO:0000269|PubMed:12445884, ECO:0000269|PubMed:14699157, ECO:0000269|PubMed:15263016, ECO:0000269|PubMed:19213956, ECO:0000269|PubMed:20605917, ECO:0000269|PubMed:23676497}.
uniprot
proteins
mass_dalton
100455
uniprot
proteins
mutagenesis
MUTAGEN 38..40; /note="INI->ANA: Loss of membrane association and DLG2-binding."; /evidence="ECO:0000269|PubMed:12807908
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by MAPK12 (PubMed:20605917). Phosphorylation of Ser-232 regulates association with GRIN2A (By similarity). {ECO:0000250|UniProtKB:Q62696, ECO:0000269|PubMed:20605917}.; PTM: Ubiquitinated; by MARCHF2 which results in its degradation. {ECO:0000269|PubMed:17980554}.
uniprot
proteins
protein_family
MAGUK family
uniprot
proteins
pubmed
10557085
uniprot
proteins
pubmed
10656683
uniprot
proteins
pubmed
10779557
uniprot
proteins
pubmed
10859302
uniprot
proteins
pubmed
11602598
uniprot
proteins
pubmed
11723125
uniprot
proteins
pubmed
12445884
uniprot
proteins
pubmed
12766944
uniprot
proteins
pubmed
12807908
uniprot
proteins
pubmed
14699157
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15021905
uniprot
proteins
pubmed
15263016
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16519681
uniprot
proteins
pubmed
16630835
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17237226
uniprot
proteins
pubmed
17332497
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
17980554
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19118189
uniprot
proteins
pubmed
19213956
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20605917
uniprot
proteins
pubmed
20702775
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21849460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23676497
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24503895
uniprot
proteins
pubmed
25268382
uniprot
proteins
pubmed
25558062
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
7477295
uniprot
proteins
pubmed
7937897
uniprot
proteins
pubmed
8638125
uniprot
proteins
pubmed
8757139
uniprot
proteins
pubmed
8922391
uniprot
proteins
pubmed
9192623
uniprot
proteins
sequence_length
904
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10859302, ECO:0000269|PubMed:11723125, ECO:0000269|PubMed:21849460, ECO:0000269|PubMed:8922391}; Peripheral membrane protein {ECO:0000269|PubMed:8922391}. Basolateral cell membrane {ECO:0000269|PubMed:12807908}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q62696}. Postsynaptic density {ECO:0000250|UniProtKB:Q62696}. Synapse {ECO:0000250|UniProtKB:Q62696}. Cell membrane, sarcolemma {ECO:0000269|PubMed:12445884}. Apical cell membrane {ECO:0000269|PubMed:12445884}. Cell junction {ECO:0000269|PubMed:10859302, ECO:0000269|PubMed:11723125, ECO:0000269|PubMed:7937897}. Cytoplasm {ECO:0000269|PubMed:10859302}. Note=Colocalizes with EPB41 at regions of intercellular contacts. Basolateral in epithelial cells (PubMed:12807908). May also associate with endoplasmic reticulum membranes. Mainly found in neurons soma, moderately found at postsynaptic densities (By similarity). {ECO:0000250|UniProtKB:Q62696, ECO:0000269|PubMed:10859302, ECO:0000269|PubMed:12807908, ECO:0000269|PubMed:8922391, ECO:0000269|PubMed:9192623}.
uniprot
proteins