RNFT2
entrez
84900
canonical
uniprot
Q96EX2
canonical
ensembl
ENSG00000135119
resolver
ensp
ENSP00000257575
resolver
ensp
ENSP00000376332
resolver
ensp
ENSP00000385669
resolver
ensp
ENSP00000775543
resolver
genesymbol
RNFT2
resolver
genesymbol_syn
TMEM118
resolver
hgnc
HGNC:25905
resolver
uniprot
E9PAM7
resolver
uniprot
Q96SU5
resolver
uniprot_entry
RNFT2_HUMAN
resolver
uniprot_sec
E9PAM7
resolver
uniprot_sec
Q96SU5
resolver
amino_acid_sequence
MWLFTVNQVLRKMQRRHSSNTDNIPPERNRSQALSSEASVDEGGVFESLKAEAASPPALFSGLSGSLPTSSFPSSLVLGSSAGGGDVFIQMPASREEGGGRGEGGAYHHRQPHHHFHHGGHRGGSLLQHVGGDHRGHSEEGGDEQPGTPAPALSELKAVICWLQKGLPFILILLAKLCFQHKLGIAVCIGMASTFAYANSTLREQVSLKEKRSVLVILWILAFLAGNTLYVLYTFSSQQLYNSLIFLKPNLEMLDFFDLLWIVGIADFVLKYITIALKCLIVALPKIILAVKSKGKFYLVIEELSQLFRSLVPIQLWYKYIMGDDSSNSYFLGGVLIVLYSLCKSFDICGRVGGVRKALKLLCTSQNYGVRATGQQCTEAGDICAICQAEFREPLILLCQHVFCEECLCLWLDRERTCPLCRSVAVDTLRCWKDGATSAHFQVY
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that negatively regulates IL3-dependent cellular responses through IL3RA ubiquitination and degradation by the proteasome, having an anti-inflammatory effect. {ECO:0000269|PubMed:31990690}.
uniprot
proteins
mass_dalton
48965
uniprot
proteins
mutagenesis
MUTAGEN 387; /note="C->A: Loss of E3 ubiquitin-protein ligase activity."; /evidence="ECO:0000269|PubMed:31990690"; MUTAGEN 401; /note="H->A: Loss of E3 ubiquitin-protein ligase activity."; /evidence="ECO:0000269|PubMed:31990690"; MUTAGEN 418; /note="C->A: Loss of E3 ubiquitin-protein ligase activity."; /evidence="ECO:0000269|PubMed:31990690
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
31990690
uniprot
proteins
sequence_length
444
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 182..202; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 215..235; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 256..276; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 330..350; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins