PIGR
entrez
5284
canonical
uniprot
P01833
canonical
ensembl
ENSG00000162896
resolver
ensp
ENSP00000348888
resolver
ensp
ENSP00000530584
resolver
ensp
ENSP00000530585
resolver
ensp
ENSP00000530586
resolver
ensp
ENSP00000530589
resolver
ensp
ENSP00000530590
resolver
ensp
ENSP00000530592
resolver
ensp
ENSP00000530598
resolver
ensp
ENSP00000612221
resolver
ensp
ENSP00000612223
resolver
ensp
ENSP00000612228
resolver
ensp
ENSP00000612229
resolver
enst
ENST00000356495
resolver
enst
ENST00000860525
resolver
enst
ENST00000860526
resolver
enst
ENST00000860527
resolver
enst
ENST00000860531
resolver
enst
ENST00000860532
resolver
enst
ENST00000860533
resolver
enst
ENST00000860539
resolver
enst
ENST00000942162
resolver
enst
ENST00000942164
resolver
enst
ENST00000942169
resolver
enst
ENST00000942170
resolver
genesymbol
PIGR
resolver
hgnc
HGNC:8968
resolver
uniprot
Q68D81
resolver
uniprot
Q8IZY7
resolver
uniprot_entry
PIGR_HUMAN
resolver
uniprot_sec
Q68D81
resolver
uniprot_sec
Q8IZY7
resolver
amino_acid_sequence
MLLFVLTCLLAVFPAISTKSPIFGPEEVNSVEGNSVSITCYYPPTSVNRHTRKYWCRQGARGGCITLISSEGYVSSKYAGRANLTNFPENGTFVVNIAQLSQDDSGRYKCGLGINSRGLSFDVSLEVSQGPGLLNDTKVYTVDLGRTVTINCPFKTENAQKRKSLYKQIGLYPVLVIDSSGYVNPNYTGRIRLDIQGTGQLLFSVVINQLRLSDAGQYLCQAGDDSNSNKKNADLQVLKPEPELVYEDLRGSVTFHCALGPEVANVAKFLCRQSSGENCDVVVNTLGKRAPAFEGRILLNPQDKDGSFSVVITGLRKEDAGRYLCGAHSDGQLQEGSPIQAWQLFVNEESTIPRSPTVVKGVAGGSVAVLCPYNRKESKSIKYWCLWEGAQNGRCPLLVDSEGWVKAQYEGRLSLLEEPGNGTFTVILNQLTSRDAGFYWCLTNGDTLWRTTVEIKIIEGEPNLKVPGNVTAVLGETLKVPCHFPCKFSSYEKYWCKWNNTGCQALPSQDEGPSKAFVNCDENSRLVSLTLNLVTRADEGWYWCGVKQGHFYGETAAVYVAVEERKAAGSRDVSLAKADAAPDEKVLDSGFREIENKAIQDPRLFAEEKAVADTRDQADGSRASVDSGSSEEQGGSSRALVSTLVPLGLVLAVGAVAVGVARARHRKNVDRVSIRSYRTDISMSDFENSREFGANDNMGASSITQETSLGGKEEFVATTESTTETKEPKKAKRSSKEEAEMAYKDFLLQSSTVAAEAQDGPQEA
uniprot
proteins
function
FUNCTION: [Polymeric immunoglobulin receptor]: Mediates selective transcytosis of polymeric IgA and IgM across mucosal epithelial cells. Binds polymeric IgA and IgM at the basolateral surface of epithelial cells. The complex is then transported across the cell to be secreted at the apical surface. During this process, a cleavage occurs that separates the extracellular (known as the secretory component) from the transmembrane segment. {ECO:0000269|PubMed:10229845, ECO:0000269|PubMed:15530357, ECO:0000269|PubMed:9379029}.; FUNCTION: [Secretory component]: Through its N-linked glycans ensures anchoring of secretory IgA (sIgA) molecules to mucus lining the epithelial surface to neutralize extracellular pathogens (PubMed:12150896). On its own (free form) may act as a non-specific microbial scavenger to prevent pathogen interaction with epithelial cells (PubMed:16543244). {ECO:0000269|PubMed:12150896, ECO:0000269|PubMed:16543244}.
uniprot
proteins
mass_dalton
83284
uniprot
proteins
mutagenesis
MUTAGEN 47; /note="V->N: Disrupts the interaction with pentameric IgM; when associated with S-49."; /evidence="ECO:0000269|PubMed:32029689"; MUTAGEN 49; /note="R->S: Disrupts the interaction with pentameric IgM; when associated with N-47."; /evidence="ECO:0000269|PubMed:32029689"; MUTAGEN 117; /note="R->N: Disrupts the interaction with pentameric IgM; when associated with T-119."; /evidence="ECO:0000269|PubMed:32029689"; MUTAGEN 119; /note="L->T: Disrupts the interaction with pentameric IgM; when associated with N-117."; /evidence="ECO:0000269|PubMed:32029689
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. N-glycosylation is required for anchoring IgA molecules to mucus, but is not necessary for Ig binding. {ECO:0000269|PubMed:12150896, ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:16543244, ECO:0000269|PubMed:16740002, ECO:0000269|PubMed:18780401, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:6526384}.
uniprot
proteins
pubmed
10229845
uniprot
proteins
pubmed
12150896
uniprot
proteins
pubmed
1355431
uniprot
proteins
pubmed
15084671
uniprot
proteins
pubmed
15530357
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
16543244
uniprot
proteins
pubmed
16740002
uniprot
proteins
pubmed
1682231
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
1859628
uniprot
proteins
pubmed
18780401
uniprot
proteins
pubmed
19079336
uniprot
proteins
pubmed
19139490
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
25946035
uniprot
proteins
pubmed
2920039
uniprot
proteins
pubmed
32029686
uniprot
proteins
pubmed
32029689
uniprot
proteins
pubmed
6526384
uniprot
proteins
pubmed
8292260
uniprot
proteins
pubmed
9237679
uniprot
proteins
pubmed
9379029
uniprot
proteins
sequence_length
764
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Polymeric immunoglobulin receptor]: Cell membrane {ECO:0000269|PubMed:9379029}; Single-pass type I membrane protein {ECO:0000255}.; SUBCELLULAR LOCATION: [Secretory component]: Secreted {ECO:0000269|PubMed:16543244, ECO:0000269|PubMed:19079336, ECO:0000269|PubMed:8292260}.
uniprot
proteins
transmembrane_region
TRANSMEM 639..661; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins