Nme6
entrez
54369
canonical
uniprot
O88425
canonical
ensembl
ENSMUSG00000032478
resolver
ensp
ENSMUSP00000035053
resolver
ensp
ENSMUSP00000142609
resolver
ensp
ENSMUSP00000142778
resolver
ensp
ENSMUSP00000143021
resolver
ensp
ENSMUSP00000215777
resolver
ensp
ENSMUSP00000215779
resolver
ensp
ENSMUSP00000215788
resolver
enst
ENSMUST00000035053
resolver
enst
ENSMUST00000197627
resolver
enst
ENSMUST00000200468
resolver
genesymbol
Nme6
resolver
uniprot
A0A0G2JEH8
resolver
uniprot
Q99M53
resolver
uniprot_entry
A0A0G2JEH8_MOUSE
resolver
uniprot_entry
NDK6_MOUSE
resolver
uniprot_sec
Q99M53
resolver
amino_acid_sequence
MTSILRSPQALQLTLALIKPDAVAHPLILEAVHQQILSNKFLIVRTRELQWKLEDCRRFYREHEGRFFYQRLVEFMTSGPIRAYILAHKDAIQLWRTLMGPTRVFRARYIAPDSIRGSLGLTDTRNTTHGSDSVVSASREIAAFFPDFSEQRWYEEEEPQLRCGPVHYSPEEGIHCAAETGGHKQPNKT
uniprot
proteins
ec_number
2.7.4.6
uniprot
proteins
function
FUNCTION: Catalytic subunit of a complex with RCC1L, which catalyzes the transfer of a gamma-phosphoryl group from a nucleoside triphosphate, mainly ATP, to a nucleoside diphosphate via a ping-pong mechanism involving the formation of a phosphohistidine intermediate. Participates in the regulation of mitochondrial nucleotide levels, mitoribosome biogenesis, and mitochondrial RNA abundances. Supplies pyrimidine ribonucleoside triphosphates (rNTPs) for mitochondrial transcription and is required for the maintenance of mitochondrial DNA (mtDNA) when the import of pyrimidine deoxyribonucleoside triphosphates (dNTPs) is limited from the cytosol is limited. As a monomer, lacks nucleoside diphosphate kinase (NDPK) activity. {ECO:0000250|UniProtKB:O75414}.
uniprot
proteins
mass_dalton
21778
uniprot
proteins
protein_family
NDK family
uniprot
proteins
pubmed
10453732
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
189
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:O75414}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:O75414}; Peripheral membrane protein {ECO:0000250|UniProtKB:O75414}. Mitochondrion {ECO:0000250|UniProtKB:O75414}. Note=Predominantly localized in mitochondrion matrix, however partially bound to mitochondrion inner membrane (MIM), peripherally bound and facing the matrix space. {ECO:0000250|UniProtKB:O75414}.
uniprot
proteins