Fam220a
entrez
498145
canonical
uniprot
Q6DGF6
canonical
ensembl
ENSRNOG00000024605
resolver
ensembl
ENSRNOG00065000102
resolver
ensp
ENSRNOP00000059765
resolver
ensp
ENSRNOP00000078852
resolver
ensp
ENSRNOP00000108143
resolver
ensp
ENSRNOP00065000167
resolver
ensp
ENSRNOP00065000168
resolver
enst
ENSRNOT00000029692
resolver
enst
ENSRNOT00000102797
resolver
enst
ENSRNOT00000143742
resolver
enst
ENSRNOT00065000168
resolver
enst
ENSRNOT00065000169
resolver
genesymbol
Fam220a
resolver
genesymbol_syn
Sipar
resolver
uniprot_entry
F220A_RAT
resolver
amino_acid_sequence
MRAGRGTLGVCLASVKQSQGGDLDKLACGLKRRSEKRNPSPSDVPSWTDQPVADTHGKSRAMAAASSEMKRDQSKASLILHSGFKALQYLKESMGRNSTPAASLSMAVVLSSAPSEEHGAGVSGGIGDTLGSDWPAREPRTTDSCGQYLKGEAWVSGWQGHPKVREVGFLRGEPLSAVPKGLGTRSELSYCSELCQLPYTYPYYEALPEDKTRCVSLDHLSPVFSEETVEDEKTLSSTSDGLQIVMGLLALQSSRLTSL
uniprot
proteins
function
FUNCTION: Promotes dephosphorylation of transcriptional activator STAT3 by interacting with both STAT3 and protein phosphatase PTPN2. This promotes interaction of PTPN2 with STAT3 and mediates STAT3 dephosphorylation by PTPN2, leading to negative regulation of STAT3 transcriptional activator activity. May be required for spermiogenesis or sperm function. {ECO:0000250|UniProtKB:Q3ZN08}.
uniprot
proteins
mass_dalton
27739
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
259
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q3ZN08}. Cytoplasm {ECO:0000250|UniProtKB:Q3ZN08}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q3ZN08}. Note=Localizes to both nucleus and cytoplasm but located predominantly in the nucleus. Detected in the sperm acrosome prior to the acrosome reaction and is likely to be released from acrosome-reacted sperm. {ECO:0000250|UniProtKB:Q3ZN08}.
uniprot
proteins