Cilk1
entrez
84411
canonical
uniprot
Q62726
canonical
ensembl
ENSRNOG00000008691
resolver
ensembl
ENSRNOG00055004610
resolver
ensembl
ENSRNOG00060019002
resolver
ensembl
ENSRNOG00065016677
resolver
ensp
ENSRNOP00000012257
resolver
ensp
ENSRNOP00055005478
resolver
ensp
ENSRNOP00060026858
resolver
ensp
ENSRNOP00065021915
resolver
enst
ENSRNOT00055007317
resolver
enst
ENSRNOT00060032859
resolver
enst
ENSRNOT00065027794
resolver
genesymbol
Cilk1
resolver
genesymbol_syn
Ick
resolver
uniprot_entry
CILK1_RAT
resolver
amino_acid_sequence
MNRYTTIKQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHANIVKLKEVIRENDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHGFFHRDLKPENLLCMGPELVKIADFGLAREIRSRPPYTDYVSTRWYRAPEVLLRSTNYSSPIDVWAVGCIMAEVYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNFIWPQCIPNNLKTLIPNASSEAIQLLRDLLQWDPKKRPTASQALRYPYFQIGHPLGISTQDSGKPQKDVQDKTGPPPYVKPAPPAQAPTKAHTLISSRPNQASQPHQHFVYPYKGEASRTEQLSHVQEGQPNPPFFPSLHNKNLPPKILAGLEQKSGDMKPKSRRRWGLISRSTKGSDDWADLADLDFSSSLTRIDVKNKKRQSDDPLCRFESVLDLKPSEPVGTGTSVSTQASSQRRDTPTLQSTAKQHYLKHSRYLPGINIRNGVLPNPGKDFLPSSSWSSSGLSGKSSGTVSVVSKITSVGSGSTSSTGLTGSYIPSFLKKEVGSVMQRVQLAPLAAPSPGYSSLKAVRPHPGRPFFHTQPRSTPGLIPRPPAVQPVHGRIDWSSKYPSRR
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Required for ciliogenesis, particularly in neuronal and retinal progenitor cells (By similarity). Phosphorylates KIF3A (By similarity). Involved in the control of ciliary length (By similarity). Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips (By similarity). May play a role in cardiac development (PubMed:8570168). Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity (By similarity). {ECO:0000250|UniProtKB:Q9JKV2, ECO:0000303|PubMed:8570168}.
uniprot
proteins
mass_dalton
70569
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated on serine and threonine residues (PubMed:8570168). Phosphorylation at Thr-157 increases kinase activity (By similarity). {ECO:0000250|UniProtKB:Q9JKV2, ECO:0000250|UniProtKB:Q9NYX3, ECO:0000269|PubMed:8570168}.
uniprot
proteins
protein_family
CDC2/CDKX subfamily
uniprot
proteins
protein_family
CMGC Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
8570168
uniprot
proteins
sequence_length
629
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:8570168}. Cell projection, cilium {ECO:0000250|UniProtKB:Q9JKV2}. Nucleus {ECO:0000250|UniProtKB:Q9UPZ9}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q9JKV2}. Note=Also found at the ciliary tip. {ECO:0000250|UniProtKB:Q9JKV2}.
uniprot
proteins