Olfm2
entrez
244723
canonical
uniprot
Q8BM13
canonical
ensembl
ENSMUSG00000032172
resolver
ensp
ENSMUSP00000034692
resolver
ensp
ENSMUSP00000149231
resolver
ensp
ENSMUSP00000151018
resolver
enst
ENSMUST00000034692
resolver
enst
ENSMUST00000215999
resolver
enst
ENSMUST00000217198
resolver
genesymbol
Olfm2
resolver
uniprot
A0A1L1SQX6
resolver
uniprot
A0A1L1SV46
resolver
uniprot
Q0VFZ0
resolver
uniprot
Q0VG58
resolver
uniprot_entry
A0A1L1SQX6_MOUSE
resolver
uniprot_entry
A0A1L1SV46_MOUSE
resolver
uniprot_entry
NOE2_MOUSE
resolver
uniprot_sec
Q0VFZ0
resolver
uniprot_sec
Q0VG58
resolver
amino_acid_sequence
MRKLRQTGTTIAGGQTLFQSPEEGWQLYTSAQAPDGKCVCTAVIPAQSTCARDGRSRELRQLMEKVQNVSQSMEVLELRTFRDLQYVRSMETLMRSLDARLRAADGSVSAKSFQELKDRMTELLPLSSVLEQYKADTRTIVRLREEVRNLSGNLAAIQEEMGAYGYEDLQQRVMALEARLHACAQKLGCGKLTGVSNPITIRAMGSRFGSWMTDTMAPSADSRVWYMDGYYKGRRVLEFRTLGDFIKGQNFIQHLLPQPWAGTGHVVYNGSLFYNKYQSNVVVKYHFRSRSVLVQRSLPGAGYNNTFPYSWGGFSDMDFMVDESGLWAVYTTNQNAGNIVVSRLDPHTLEVVRSWDTGYPKRSAGEAFMICGVLYVTNSHLAGAKVYFAYFTNTSSYEYTDVPFHNQYSHISMLDYNPRERALYTWNNGHQVLYNVTLFHVISTAGDP
uniprot
proteins
function
FUNCTION: Involved in transforming growth factor beta (TGF-beta)-induced smooth muscle differentiation (By similarity). TGF-beta induces expression and nuclear translocation of OLFM2 where it binds to SRF, causing its dissociation from the transcriptional repressor HEY2/HERP1 and facilitating binding of SRF to target genes (By similarity). Plays a role in AMPAR complex organization (PubMed:25218043). Is a regulator of vascular smooth-muscle cell (SMC) phenotypic switching, that acts by promoting RUNX2 and inhibiting MYOCD binding to SRF. SMC phenotypic switching is the process through which vascular SMCs undergo transition between a quiescent contractile phenotype and a proliferative synthetic phenotype in response to pathological stimuli. SMC phenotypic plasticity is essential for vascular development and remodeling (By similarity). {ECO:0000250|UniProtKB:O95897, ECO:0000250|UniProtKB:Q568Y7, ECO:0000269|PubMed:25218043}.
uniprot
proteins
mass_dalton
50720
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21228389
uniprot
proteins
pubmed
22632720
uniprot
proteins
pubmed
25218043
uniprot
proteins
pubmed
28062493
uniprot
proteins
sequence_length
448
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:O95897}. Synapse {ECO:0000269|PubMed:25218043, ECO:0000305|PubMed:22632720}. Membrane {ECO:0000269|PubMed:25218043}. Nucleus {ECO:0000250|UniProtKB:O95897}. Cytoplasm {ECO:0000250|UniProtKB:O95897}. Note=Nuclear localization is induced by TGF-beta. {ECO:0000250|UniProtKB:O95897}.
uniprot
proteins