RAC2
entrez
5880
canonical
uniprot
P15153
canonical
ensembl
ENSG00000128340
resolver
ensp
ENSP00000249071
resolver
ensp
ENSP00000540440
resolver
ensp
ENSP00000540442
resolver
ensp
ENSP00000662903
resolver
enst
ENST00000249071
resolver
enst
ENST00000870381
resolver
enst
ENST00000870383
resolver
genesymbol
RAC2
resolver
hgnc
HGNC:9802
resolver
uniprot
Q9UDJ4
resolver
uniprot
V9H0H7
resolver
uniprot_entry
RAC2_HUMAN
resolver
uniprot_entry
V9H0H7_HUMAN
resolver
uniprot_sec
Q9UDJ4
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. {ECO:0000269|PubMed:30723080}.
uniprot
proteins
amino_acid_sequence
MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDSKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASYENVRAKWFPEVRHHCPSTPIILVGTKLDLRDDKDTIEKLKEKKLAPITYPQGLALAKEIDSVKYLECSALTQRGLKTVFDEAIRAVLCPQPTRQQKRACSLL
uniprot
proteins
disease_involvement
DISEASE: Immunodeficiency 73A with defective neutrophil chemotaxis and leukocytosis (IMD73A) [MIM:608203]: An autosomal dominant immunologic disorder characterized by onset of recurrent infections in early infancy, leukocytosis, neutrophilia, invasive infections, and poor wound healing. {ECO:0000269|PubMed:10758162}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Immunodeficiency 73B with defective neutrophil chemotaxis and lymphopenia (IMD73B) [MIM:618986]: An autosomal dominant immunologic disorder characterized by respiratory infections, cellulitis, severe invasive infections, B- and T-cell lymphopenia, and impaired neutrophil chemotaxis. Disease onset is in infancy or early childhood. {ECO:0000269|PubMed:30654050, ECO:0000269|PubMed:30723080, ECO:0000269|PubMed:31071452, ECO:0000269|PubMed:31382036}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Immunodeficiency 73C with defective neutrophil chemotaxis and hypogammaglobulinemia (IMD73C) [MIM:618987]: An autosomal recessive immunologic disorder characterized by recurrent respiratory infections, decreased B cells, hypogammaglobulinemia, and impaired neutrophil chemotaxis. Variable features are urticaria, recurrent erythematous plaques, food allergy, arthralgia, bronchiectasis, and lymphadenopathy. In addition, patients suffer from glomerulonephritis, coagulopathy, multiple hormone deficiencies, and abnormalities of neutrophil granules. {ECO:0000269|PubMed:25512081}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state (PubMed:30723080). In its active state, binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Regulatory subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)) (PubMed:1660188). Activates PLCG2 (PubMed:19394299). {ECO:0000269|PubMed:1660188, ECO:0000269|PubMed:19394299, ECO:0000269|PubMed:30723080}.
uniprot
proteins
mass_dalton
21429
uniprot
proteins
mutagenesis
MUTAGEN 189; /note="C->W: Abolishes in vitro prenylation."; /evidence="ECO:0000269|PubMed:1903399
uniprot
proteins
post_translational_modification
PTM: (Microbial infection) Glycosylated at Tyr-32 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rac and leads to actin disassembly. {ECO:0000269|PubMed:24141704}.
uniprot
proteins
protein_family
Rho family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10559471
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
10655614
uniprot
proteins
pubmed
10758162
uniprot
proteins
pubmed
1316893
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15642721
uniprot
proteins
pubmed
1660188
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
1902092
uniprot
proteins
pubmed
19028840
uniprot
proteins
pubmed
1903399
uniprot
proteins
pubmed
19394299
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24141704
uniprot
proteins
pubmed
25512081
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
2674130
uniprot
proteins
pubmed
30654050
uniprot
proteins
pubmed
30723080
uniprot
proteins
pubmed
31071452
uniprot
proteins
pubmed
31382036
uniprot
proteins
pubmed
8504089
uniprot
proteins
sequence_length
192
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Note=Membrane-associated when activated.
uniprot
proteins