Chst1
entrez
76969
canonical
uniprot
Q9EQC0
canonical
ensembl
ENSMUSG00000027221
resolver
ensp
ENSMUSP00000064246
resolver
ensp
ENSMUSP00000324573
resolver
ensp
ENSMUSP00000324574
resolver
ensp
ENSMUSP00000324577
resolver
ensp
ENSMUSP00000324582
resolver
enst
ENSMUST00000065797
resolver
genesymbol
Chst1
resolver
genesymbol_syn
Gst1
resolver
uniprot
Q3UY35
resolver
uniprot
Q9D0K5
resolver
uniprot_entry
CHST1_MOUSE
resolver
uniprot_entry
Q3UY35_MOUSE
resolver
uniprot_sec
Q9D0K5
resolver
amino_acid_sequence
MQCSWKAVLLLALASIAIQYTAIRTFTAKSFHTCPGLTDTGLAERLCEEGPTFSYNLSRKTHVLILATTRSGSSFVGQLFNQHMDVFYLFEPLYHVQNTLIPRFTQGKSPADRRVMLGASRDLLRSLYDCDLYFLENYIKPPPVNHTTNRVFRRGASRVLCSRPVCDPPGSSDLILEEGDCVRMCGLLNLTLAAEACRERSHVAIKTVRVPEVNDLRALVEDPRLNLKVIQLVRDPRGILASRSETFRDTYRLWRLWYGTGRKPYNLDVTQLTTVCEDFSSSVSTGLMRPSWLKGKYMLVRYEDLARNPMKKTEEIYEFLGIPLDSHVAHWIQNNTRGDPTLGKHKYSTVRNSAATAEKWRFRLSYDIVAFAQNACQQVLAQLGYKMANSEEELKNPAISLVEERDFRPFL
uniprot
proteins
ec_number
2.8.2.21
uniprot
proteins
function
FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of internal galactose (Gal) residues of keratan. Cooperates with B4GALT4 and B3GNT7 glycosyltransferases and CHST6 sulfotransferase to construct and elongate disulfated disaccharide unit [->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer (By similarity). Involved in biosynthesis of phosphacan, a major keratan sulfate proteoglycan in the developing brain (PubMed:24152993). Involved in biosynthesis of 6-sulfoGalbeta-containing O-linked glycans in high endothelial venules of lymph nodes. May act in a synergistic manner with CHST4 to generate sialyl 6',6-disulfo Lewis X motif, a recognition determinant for immune cell receptors implicated in leukocyte trafficking (By similarity) (PubMed:23254996). Catalyzes sulfation of N-acetyllactosamine (LacNAc) oligosaccharides with highest efficiency for sialylated LacNAc structures (By similarity). {ECO:0000250|UniProtKB:O43916, ECO:0000269|PubMed:23254996, ECO:0000269|PubMed:24152993}.
uniprot
proteins
mass_dalton
46904
uniprot
proteins
pathway_participation
PATHWAY: Glycan metabolism. {ECO:0000269|PubMed:24152993}.
uniprot
proteins
protein_family
Gal/GlcNAc/GalNAc subfamily
uniprot
proteins
protein_family
Sulfotransferase 1 family
uniprot
proteins
pubmed
11181564
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23254996
uniprot
proteins
pubmed
24152993
uniprot
proteins
sequence_length
411
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 3..23; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins