Swsap1
entrez
66962
canonical
uniprot
Q8VCI7
canonical
ensembl
ENSMUSG00000051238
resolver
ensp
ENSMUSP00000060331
resolver
enst
ENSMUST00000053583
resolver
genesymbol
Swsap1
resolver
uniprot
A7E2S1
resolver
uniprot
Q8BRM3
resolver
uniprot
Q9CV33
resolver
uniprot_entry
SWAP1_MOUSE
resolver
uniprot_sec
A7E2S1
resolver
uniprot_sec
Q8BRM3
resolver
uniprot_sec
Q9CV33
resolver
amino_acid_sequence
MAEALRRVLNAGCAARPGEDGAAGPPLLLLGAPRSAQTSLLFAAALEAAGEGRGSVLFVTRRPLQSLPLSTPTAREHWRLQKVRFQYPSSIQELLQLLASAHEAPAPTPSLLLLDGLEEYLAEDPSAQEAAYLAALLLDTAAFFSHRLGANGSCGLVVALETQKEAEADAPHLPLLKRYFPAQCWLQPDALGLGQHCCLRASLELGKLSPRTEWSVSFLPCGEMKVTPWLAQASKLSPEKKDSSAGSQSLTLGCDNLPGPGSPLDGILTSETGADSKT
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: Single-stranded DNA-stimulated ATPase involved in DNA double-strand break (DSB) repair via homologous recombination (HR) (PubMed:30305635, PubMed:34253720). Forms a heterodimeric complex with ZSWIM7/SWS1 that promotes HR by regulating replication protein-A (RPA) dynamics on single-stranded DNA, thereby stabilizing RAD51 and DMC1 filaments on DNA (PubMed:30305635, PubMed:34253720). The SWSAP1-ZSWIM7/SWS1 heterodimer is essential during meiosis by stabilizing DMC1 filaments (PubMed:30305635, PubMed:34253720). In contrast, it is critical for only certain types of homologous-directed DNA repair, such as inter-homolog homologous recombination (IR-HR) (PubMed:34253720). IR-HR is a DNA repair mechanism where a cell repairs a DSB on one chromosome using the matching homologous chromosome as a template, rather than the sister chromatid (PubMed:34253720). Also promotes homologous recombination by inactivating the FIGNL1-FIRRM complex to protect RAD51 filament from premature disassembly (By similarity). Has a DNA-binding activity which is independent of its ATPase activity: preferentially binds DNA with an exposed 5' end (By similarity). {ECO:0000250|UniProtKB:Q6NVH7, ECO:0000269|PubMed:30305635, ECO:0000269|PubMed:34253720}.
uniprot
proteins
mass_dalton
29385
uniprot
proteins
mutagenesis
MUTAGEN 37; /note="Q->A: Does not affect ability to promote DNA repair via inter-homolog homologous recombination (IR-HR)."; /evidence="ECO:0000269|PubMed:34253720"; MUTAGEN 42; /note="F->E: Abolished ability to promote DNA repair via inter-homolog homologous recombination (IR-HR)."; /evidence="ECO:0000269|PubMed:34253720"; MUTAGEN 115; /note="D->A: Does not affect ability to promote DNA repair via inter-homolog homologous recombination (IR-HR)."; /evidence="ECO:0000269|PubMed:34253720
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
30305635
uniprot
proteins
pubmed
34253720
uniprot
proteins
sequence_length
278
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q6NVH7}. Nucleus {ECO:0000250|UniProtKB:Q6NVH7}.
uniprot
proteins