CRTC3
entrez
64784
canonical
uniprot
Q6UUV7
canonical
ensembl
ENSG00000140577
resolver
ensp
ENSP00000268184
resolver
ensp
ENSP00000416573
resolver
genesymbol
CRTC3
resolver
genesymbol_syn
TORC3
resolver
hgnc
HGNC:26148
resolver
uniprot
Q6DK61
resolver
uniprot
Q6DK62
resolver
uniprot
Q8NF38
resolver
uniprot
Q9H6U2
resolver
uniprot_entry
CRTC3_HUMAN
resolver
uniprot_sec
Q6DK61
resolver
uniprot_sec
Q6DK62
resolver
uniprot_sec
Q8NF38
resolver
uniprot_sec
Q9H6U2
resolver
amino_acid_sequence
MAASPGSGSANPRKFSEKIALHTQRQAEETRAFEQLMTDLTLSRVQFQKLQQLRLTQYHGGSLPNVSQLRSSASEFQPSFHQADNVRGTRHHGLVERPSRNRFHPLHRRSGDKPGRQFDGSAFGANYSSQPLDESWPRQQPPWKDEKHPGFRLTSALNRTNSDSALHTSALSTKPQDPYGGGGQSAWPAPYMGFCDGENNGHGEVASFPGPLKEENLLNVPKPLPKQLWETKEIQSLSGRPRSCDVGGGNAFPHNGQNLGLSPFLGTLNTGGSLPDLTNLHYSTPLPASLDTTDHHFGSMSVGNSVNNIPAAMTHLGIRSSSGLQSSRSNPSIQATLNKTVLSSSLNNHPQTSVPNASALHPSLRLFSLSNPSLSTTNLSGPSRRRQPPVSPLTLSPGPEAHQGFSRQLSSTSPLAPYPTSQMVSSDRSQLSFLPTEAQAQVSPPPPYPAPQELTQPLLQQPRAPEAPAQQPQAASSLPQSDFQLLPAQGSSLTNFFPDVGFDQQSMRPGPAFPQQVPLVQQGSRELQDSFHLRPSPYSNCGSLPNTILPEDSSTSLFKDLNSALAGLPEVSLNVDTPFPLEEELQIEPLSLDGLNMLSDSSMGLLDPSVEETFRADRL
uniprot
proteins
function
FUNCTION: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR). {ECO:0000269|PubMed:14506290, ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15466468, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:16980408, ECO:0000269|PubMed:17210223, ECO:0000269|PubMed:17644518}.
uniprot
proteins
mass_dalton
66959
uniprot
proteins
mutagenesis
MUTAGEN 282; /note="Y->F: Translocates to the cytoplasm. Represses basal TORC3 activity towards CREB."; /evidence="ECO:0000269|PubMed:15454081
uniprot
proteins
post_translational_modification
PTM: Phosphorylation/dephosphorylation states of Ser-273 are required for regulating transduction of CREB activity (By similarity). CRTCs/TORCs are inactive when phosphorylated, and active when dephosphorylated at this site (By similarity). May be phosphorylated at Ser-391 by MAPK3/ERK1 and/or MAPK1/ERK2 or by some cyclin-dependent kinases such as CDK1,CDK2 or CDK5 (PubMed:30611118). Following adenylyl cyclase activation, dephosphorylated at Ser-162 and Ser-273 resulting in its dissociation from 14-3-3 proteins probably promoting CRTC3 translocation into the nucleus (PubMed:30611118). {ECO:0000250|UniProtKB:Q91X84, ECO:0000269|PubMed:30611118}.
uniprot
proteins
protein_family
TORC family
uniprot
proteins
pubmed
12693554
uniprot
proteins
pubmed
14506290
uniprot
proteins
pubmed
14536081
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15454081
uniprot
proteins
pubmed
15466468
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15589160
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
16809310
uniprot
proteins
pubmed
16817901
uniprot
proteins
pubmed
16980408
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17210223
uniprot
proteins
pubmed
17644518
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
30611118
uniprot
proteins
sequence_length
619
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:15589160, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:30611118}. Cytoplasm {ECO:0000269|PubMed:15589160, ECO:0000269|PubMed:16817901, ECO:0000269|PubMed:30611118}. Note=Appears to be mainly nuclear (PubMed:15454081). Translocates to the nucleus following adenylyl cyclase or MAP kinase activation (PubMed:30611118). {ECO:0000269|PubMed:15454081, ECO:0000269|PubMed:30611118}.
uniprot
proteins