Gpr183
entrez
679975
canonical
uniprot
D4A7K7
canonical
ensembl
ENSRNOG00000025094
resolver
ensembl
ENSRNOG00060008741
resolver
ensp
ENSRNOP00000035137
resolver
ensp
ENSRNOP00000097517
resolver
ensp
ENSRNOP00000104804
resolver
ensp
ENSRNOP00000106344
resolver
ensp
ENSRNOP00000110942
resolver
ensp
ENSRNOP00060011264
resolver
ensp
ENSRNOP00060011268
resolver
enst
ENSRNOT00000034560
resolver
enst
ENSRNOT00000098097
resolver
enst
ENSRNOT00000122520
resolver
enst
ENSRNOT00000153084
resolver
enst
ENSRNOT00000155187
resolver
enst
ENSRNOT00060014608
resolver
enst
ENSRNOT00060014613
resolver
genesymbol
Gpr183
resolver
genesymbol_syn
Ebi2
resolver
uniprot_entry
GP183_RAT
resolver
amino_acid_sequence
MANNFTTPLAASHGNNCDLYAHHSTARILMPLHYSLVFIIGLVGNLLALVVIVQNRKKINSTTLYSMNLVISDILFTTALPTRIVYYALGFDWRIGDALCRITALLFYINTYAGVNFMTCLSIDRFFAVVHPLRYNKIKRIEYAKGICVFVWILVFAQTLPLLLKPMSKQEADKTTCMEYPNFEGTASLPWILLGACLLGYVLPLAIILLCYSQICCKLFRTAKQNPLTEKSGVNKKALNTIILIIGVFVLCFTPYHVAIMQHMVKTLYAPGALGCGVRHSFQISLHFTVCLMNFNCCMDPFIYFFACKGYKRKVMKMLKRQVSVSISSAVRSAPEENSREMTESQMMIHSKASNGR
uniprot
proteins
function
FUNCTION: G protein-coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (By similarity). Receptor for oxysterol 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (By similarity). Mediates cell positioning and movement of a number of cells by binding the 7-alpha,25-OHC ligand that forms a chemotactic gradient (By similarity). Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses (By similarity). Guides B-cell movement along the B-cell zone-T-cell zone boundary and later to interfollicular and outer follicular regions (By similarity). Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T-dependent antibody responses (By similarity). Collaborates with CXCR5 to mediate B-cell migration; probably by forming a heterodimer with CXCR5 that affects the interaction between of CXCL13 and CXCR5 (By similarity). Also acts as a chemotactic receptor for some T-cells upon binding to 7-alpha,25-OHC ligand (By similarity). Promotes follicular helper T (Tfh) cells differentiation by positioning activated T-cells at the follicle-T-zone interface, promoting contact of newly activated CD4 T-cells with activated dendritic cells and exposing them to Tfh-cell-promoting inducible costimulator (ICOS) ligand (By similarity). Expression in splenic dendritic cells is required for their homeostasis, localization and ability to induce B- and T-cell responses: GPR183 acts as a chemotactic receptor in dendritic cells that mediates the accumulation of CD4(+) dendritic cells in bridging channels (By similarity). Regulates migration of astrocytes and is involved in communication between astrocytes and macrophages (By similarity). Promotes osteoclast precursor migration to bone surfaces (By similarity). Signals constitutively through G(i)-alpha, but not G(s)-alpha or G(q)-alpha (By similarity). Signals constitutively also via MAPK1/3 (ERK1/2) (By similarity). {ECO:0000250|UniProtKB:P32249, ECO:0000250|UniProtKB:Q3U6B2}.
uniprot
proteins
mass_dalton
40227
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
357
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P32249}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 33..53; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 69..89; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 102..122; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 144..164; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 191..211; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 241..261; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 288..308; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins