Rtn3
entrez
140945
canonical
uniprot
Q6RJR6
canonical
ensembl
ENSRNOG00000021202
resolver
ensembl
ENSRNOG00055023289
resolver
ensembl
ENSRNOG00060032975
resolver
ensembl
ENSRNOG00065031910
resolver
ensp
ENSRNOP00000028785
resolver
ensp
ENSRNOP00000080451
resolver
ensp
ENSRNOP00000091327
resolver
ensp
ENSRNOP00000096049
resolver
enst
ENSRNOT00000099817
resolver
enst
ENSRNOT00000113924
resolver
enst
ENSRNOT00000114634
resolver
genesymbol
Rtn3
resolver
uniprot
A0A8I6AFX0
resolver
uniprot
A0A8I6ASN6
resolver
uniprot
A0A8I6G4J6
resolver
uniprot
Q6P6R3
resolver
uniprot
Q8VBU0
resolver
uniprot_entry
A0A8I6AFX0_RAT
resolver
uniprot_entry
A0A8I6ASN6_RAT
resolver
uniprot_entry
A0A8I6G4J6_RAT
resolver
uniprot_entry
RTN3_RAT
resolver
uniprot_sec
Q6P6R3
resolver
uniprot_sec
Q8VBU0
resolver
amino_acid_sequence
MAESSAATQSPSVSSSSSGAEPSTLGGGGGSPGACPALGAKSCGSSCAVGLSSLCSDEPPSKIMTSSFLSSSEIYNPDPTTPLGSETLGSHLVAKDGKDPLVLLDKKTLDSPQGTNKDRVDTPVSLAADIPCSHPSIPDSFPEQPTFLSKETDPTEEWVVKNQEPKNPSEVPSGEDRSALDLGQRKAEHICTHSLSPSEPAVASVEKDSPESPFEVIIDKATFDREFKDLYKESTDDLGGWAAHGDRESPADLLEMNDKVFPLRNKEAGRYPSSALLGRQFSHTTAALEEVSRCVNDMHNFTNEILTWDLDPQAKQQADKSPCTTESTGLDRSEHRSEIPVINLKTSPQQKMPVCSFNGSTPITRSTGDWTETFTEGKPVKGYLSSTKEAGGKGVPDSSQPISGSGAATVEVTLPDLRGTWPNSVLGEVTEVDSSGESDDTVIEDTTENPSVKNNKVLPEKSDSLPSAAVKTSERENKETTSHETVRSEMYENSEQQQAHAETPTQRSLEGQMSPQVPNMLNEVIPENLAMTDTTRVCSAAPPSVLSETGFSLTVPASAKSESLLGKNVEDTDGSSPEDLMAALTGTEEKGTVDKEKGDVLEAVLEKIANVKNTLPVELLHENKLSSSETKNTKSKYSEHSRETNGGAPKVSSDLEQEQLTIRAIKELGAKQVQAERMSPGGKLKRTFDPQSGPQNSSDILEHTDITTGSDLGIPKKPTIIKDTRIDSISSLTKTETVNKHVLARLLSDFPVHDLIFWRDVKKTGFVFGTTLIMLLSLAAFSVISVVSYLILALLSVTISFRVYKSVIQAVQKSEEGHPFKAYLDVDITLSSEAFHSYMNAAMVHVNKALKLIIRLFLVEDLVDSLKLAVFMWLMTYVGAVFNGITLLILAELLVFSVPIVYEKYKTQIDHYVGIARDQTKSIVEKIQAKLPGIAKKKAE
uniprot
proteins
function
FUNCTION: May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules. Acts also as an inflammation-resolving regulator by interacting with both TRIM25 and RIGI, subsequently impairing RIGI 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. {ECO:0000250|UniProtKB:O95197}.
uniprot
proteins
mass_dalton
101517
uniprot
proteins
pubmed
12832288
uniprot
proteins
pubmed
14746891
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15946766
uniprot
proteins
pubmed
19665976
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
940
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O95197}; Multi-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000250|UniProtKB:O95197}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins