Ctsb
entrez
13030
canonical
uniprot
P10605
canonical
ensembl
ENSMUSG00000021939
resolver
ensp
ENSMUSP00000006235
resolver
enst
ENSMUST00000006235
resolver
genesymbol
Ctsb
resolver
uniprot
Q3UDW7
resolver
uniprot_entry
CATB_MOUSE
resolver
uniprot_sec
Q3UDW7
resolver
amino_acid_sequence
MWWSLILLSCLLALTSAHDKPSFHPLSDDLINYINKQNTTWQAGRNFYNVDISYLKKLCGTVLGGPKLPGRVAFGEDIDLPETFDAREQWSNCPTIGQIRDQGSCGSCWAFGAVEAISDRTCIHTNGRVNVEVSAEDLLTCCGIQCGDGCNGGYPSGAWSFWTKKGLVSGGVYNSHVGCLPYTIPPCEHHVNGSRPPCTGEGDTPRCNKSCEAGYSPSYKEDKHFGYTSYSVSNSVKEIMAEIYKNGPVEGAFTVFSDFLTYKSGVYKHEAGDMMGGHAIRILGWGVENGVPYWLAANSWNLDWGDNGFFKILRGENHCGIESEIVAGIPRTDQYWGRF
uniprot
proteins
ec_number
3.4.22.1
uniprot
proteins
function
FUNCTION: Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (By similarity). Cleaves matrix extracellular phosphoglycoprotein MEPE (By similarity). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (PubMed:12782676). Has also been implicated in tumor invasion and metastasis (By similarity). {ECO:0000250|UniProtKB:P07858, ECO:0000269|PubMed:12782676}.
uniprot
proteins
mass_dalton
37280
uniprot
proteins
protein_family
Peptidase C1 family
uniprot
proteins
pubmed
12782676
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
1746902
uniprot
proteins
pubmed
1889751
uniprot
proteins
pubmed
2012677
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2226854
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
3463996
uniprot
proteins
sequence_length
339
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome {ECO:0000269|PubMed:12782676}. Melanosome {ECO:0000250|UniProtKB:P07858}. Secreted, extracellular space {ECO:0000269|PubMed:12782676}. Apical cell membrane {ECO:0000269|PubMed:12782676}; Peripheral membrane protein {ECO:0000269|PubMed:12782676}; Extracellular side {ECO:0000269|PubMed:12782676}. Note=Localizes to the lumen of thyroid follicles and to the apical membrane of thyroid epithelial cells. {ECO:0000269|PubMed:12782676}.
uniprot
proteins