NKIRAS2
entrez
28511
canonical
uniprot
Q9NYR9
canonical
ensembl
ENSG00000168256
resolver
ensp
ENSP00000303580
resolver
ensp
ENSP00000377459
resolver
ensp
ENSP00000377463
resolver
ensp
ENSP00000401976
resolver
ensp
ENSP00000465633
resolver
ensp
ENSP00000590293
resolver
genesymbol
NKIRAS2
resolver
genesymbol_syn
KBRAS2
resolver
hgnc
HGNC:17898
resolver
uniprot
A6NCZ5
resolver
uniprot
B3KNN0
resolver
uniprot
B4DNM3
resolver
uniprot
Q6PK52
resolver
uniprot
Q96KC7
resolver
uniprot
Q9NSX1
resolver
uniprot_entry
KBRS2_HUMAN
resolver
uniprot_sec
A6NCZ5
resolver
uniprot_sec
B3KNN0
resolver
uniprot_sec
B4DNM3
resolver
uniprot_sec
Q6PK52
resolver
uniprot_sec
Q96KC7
resolver
uniprot_sec
Q9NSX1
resolver
amino_acid_sequence
MGKSCKVVVCGQASVGKTSILEQLLYGNHVVGSEMIETQEDIYVGSIETDRGVREQVRFYDTRGLRDGAELPRHCFSCTDGYVLVYSTDSRESFQRVELLKKEIDKSKDKKEVTIVVLGNKCDLQEQRRVDPDVAQHWAKSEKVKLWEVSVADRRSLLEPFVYLASKMTQPQSKSAFPLSRKNKGSGSLDG
uniprot
proteins
function
FUNCTION: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
21508
uniprot
proteins
mutagenesis
MUTAGEN 41; /note="D->L: Does not affect interaction with GFOD1."; /evidence="ECO:0000269|PubMed:38946427"; MUTAGEN 42; /note="I->D: Impairs the interaction with GFOD1."; /evidence="ECO:0000269|PubMed:38946427"; MUTAGEN 44; /note="V->D: Does not affect interaction with GFOD1."; /evidence="ECO:0000269|PubMed:38946427
uniprot
proteins
protein_family
KappaB-Ras subfamily
uniprot
proteins
protein_family
Ras family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
10657303
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
38946427
uniprot
proteins
sequence_length
191
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins