Tmed1
entrez
315461
canonical
uniprot
Q5BK85
canonical
ensembl
ENSRNOG00000008037
resolver
ensembl
ENSRNOG00065012338
resolver
ensp
ENSRNOP00000057728
resolver
ensp
ENSRNOP00000084813
resolver
ensp
ENSRNOP00065015410
resolver
enst
ENSRNOT00000061009
resolver
enst
ENSRNOT00000100773
resolver
enst
ENSRNOT00065020091
resolver
genesymbol
Tmed1
resolver
genesymbol_syn
Il1rl1l
resolver
uniprot
A0A8I6A1Y9
resolver
uniprot_entry
A0A8I6A1Y9_RAT
resolver
uniprot_entry
TMED1_RAT
resolver
amino_acid_sequence
MMAAGAAVALALWLLLPAVGVGEAGPPPIQDGEFTFLLPAGRKQCFYQSAPANASLETEYQVIGGAGLDVDFTLESPQGVLLVSESRKADGVHTVEPTEAGDYRLCFDNSFSTISEKLVFFELIFDSFQDEEEVEGWAEAVEPEEMLDVKMEDIKESIETMRTRLERSIQMLTLLRAFEARDRNLQEDNLERVNFWSAANVAVLLLVAVLQVCTLKRFFHDKCPVPT
uniprot
proteins
function
FUNCTION: Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. Plays a positive role in IL-33-mediated IL-8 and IL-6 production by interacting with interleukin-33 receptor IL1RL1. Plays also a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26. {ECO:0000250|UniProtKB:Q13445}.
uniprot
proteins
mass_dalton
25210
uniprot
proteins
protein_family
EMP24/GP25L family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
227
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q13445}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q13445}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q13445}; Single-pass type I membrane protein {ECO:0000255}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:Q13445}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 195..215; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins