Slc46a3
entrez
71706
canonical
uniprot
Q9DC26
canonical
ensembl
ENSMUSG00000029650
resolver
ensp
ENSMUSP00000031655
resolver
ensp
ENSMUSP00000113879
resolver
enst
ENSMUST00000031655
resolver
enst
ENSMUST00000118527
resolver
genesymbol
Slc46a3
resolver
uniprot_entry
S46A3_MOUSE
resolver
amino_acid_sequence
MKISFIEPAILLNAFAMTLTIPLTAQYVYRRIWEETGNYTFASNSNGSECDQNKSSSIFAFREEVQKKASLFNLQVEMSALIPGLVSTFMLLASSDNHGRKLPMVLSSLGSLGTNTWLCMMSYFDLPLQLLIASTFIGALFGNYTTFWGACFAYIVDQQKEYKHRIIRIAILDFMLGVVTGLTGLSSGYFIRELGFVWSYFITAMVLIVNLAYILFFLNDPIKESSSQIVTMSCIESLKDLFYRTYMLFKNGSSKRQALLCLLIFTLVIYFFVIIGISPIFTLYELGPPLCWNEVYIGYGSALGSVSFLSSFLGIWLFSYCLKDIHIAYIGIFTTMVGMTLAAFTRTTLMMFLVRIPFIFTIMPLSVLRSMLSKVVHSTEQGALFACIAFLETLAGVTSTSAYSGIYSATVAWYPGFIFLLSAGLLVLPAISLCCVKSIGWEEGSYTLLVHEEPSEHTSD
uniprot
proteins
function
FUNCTION: Lysosomal proton-coupled steroid conjugate and bile acid transporter. Preferentially recognizes lipophilic steroid conjugates or bile acis as endogenous substrates and seems to mediate escape from lysosomes to the cytoplasm (By similarity). Modulates hepatic cytosolic copper homeostasis, maybe acting as a lysosomal copper transporter and sequestering copper ions in the lysosome (PubMed:33436590). Delivers pathogen-associated molecular patterns to cytosolic pattern recognition receptors as part of the innate immune response to microbes. Selectively transports bacterial muramyl dipeptide (MDP) into the cytosol for recognition by NOD2, triggering inflammatory responses (PubMed:28539433, PubMed:37116499). Likely acts as a redundant importer of cyclic GMP-AMP dinucleotides (cGAMPs) in monocyte and macrophage cell lineages (PubMed:34235268). The transport mechanism, its electrogenicity and stoichiometry remain to be elucidated (Probable). {ECO:0000250|UniProtKB:Q7Z3Q1, ECO:0000269|PubMed:28539433, ECO:0000269|PubMed:33436590, ECO:0000269|PubMed:34235268, ECO:0000269|PubMed:37116499, ECO:0000305}.
uniprot
proteins
mass_dalton
51383
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
SLC46A family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
28539433
uniprot
proteins
pubmed
33436590
uniprot
proteins
pubmed
34235268
uniprot
proteins
pubmed
37116499
uniprot
proteins
sequence_length
460
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:33436590}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 74..94; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 112..132; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 136..156; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 171..191; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 196..216; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 258..278; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 302..322; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 325..345; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 348..368; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 382..402; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 411..431; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins