Gadd45gip1
entrez
102060
canonical
uniprot
Q9CR59
canonical
ensembl
ENSMUSG00000033751
resolver
ensp
ENSMUSP00000037783
resolver
enst
ENSMUST00000036734
resolver
genesymbol
Gadd45gip1
resolver
genesymbol_syn
Mrpl59
resolver
uniprot
Q8BT05
resolver
uniprot_entry
G45IP_MOUSE
resolver
uniprot_sec
Q8BT05
resolver
amino_acid_sequence
MAALAMRSGYLLRLSVALGPRSRSYRAPPPPRRRPGPHSPDPENLLTPRWQLTPRYVAKQFGRHGAISGVPPASLWPTPEQLRELEAEEQEWYPSLATMQESLRLQQQALEARRQAREQRIAECMAKMPQMIENWRKQKRERWEKIQADKERRARLQAEAQERLGYHVDPRSARFQELLQDLDKQQRKRLKEERQRQKKEARIAAMASAEAQDSAVSGEPSS
uniprot
proteins
function
FUNCTION: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but also occur in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis. {ECO:0000250|UniProtKB:Q8TAE8}.
uniprot
proteins
mass_dalton
25820
uniprot
proteins
protein_family
Mitochondrion-specific ribosomal protein mL64 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
222
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:Q8TAE8}. Nucleus {ECO:0000250|UniProtKB:Q8TAE8}. Note=Using N-terminally tagged constructs, has been found in the nucleus. C-terminally tagged constructs are targeted exclusively to mitochondria. This discrepancy may be explained by masking of a potential N-terminal mitochondrial targeting signal by the tag. {ECO:0000250|UniProtKB:Q8TAE8}.
uniprot
proteins