OSBPL10
entrez
114884
canonical
uniprot
Q9BXB5
canonical
ensembl
ENSG00000144645
resolver
ensp
ENSP00000379804
resolver
ensp
ENSP00000406124
resolver
ensp
ENSP00000416078
resolver
genesymbol
OSBPL10
resolver
genesymbol_syn
ORP10
resolver
genesymbol_syn
OSBP9
resolver
hgnc
HGNC:16395
resolver
uniprot
B4E212
resolver
uniprot
Q9BTU5
resolver
uniprot
Q9NX98
resolver
uniprot_entry
OSB10_HUMAN
resolver
uniprot_entry
Q9NX98_HUMAN
resolver
uniprot_sec
B4E212
resolver
uniprot_sec
Q9BTU5
resolver
amino_acid_sequence
MERAVQGTDGGGGSNSSSRSSSRATSAGSSPSCSLAGRGVSSRSAAAGLGGGGSRSSPGSVAASPSGGGGRRREPALEGVLSKYTNLLQGWQNRYFVLDFEAGILQYFVNEQSKHQKPRGVLSLSGAIVSLSDEAPHMLVVYSANGEMFKLRAADAKEKQFWVTQLRACAKYHMEMNSKSAPSSRSRSLTLLPHGTPNSASPCSQRHLSVGAPGVVTITHHKSPAAARRAKSQYSGQLHEVREMMNQVEGQQKNLVHAIESLPGSGPLTALDQDLLLLKATSAATLSCLGECLNLLQQSVHQAGQPSQKPGASENILGWHGSKSHSTEQLKNGTLGSLPSASANITWAILPNSAEDEQTSQPEPEPNSGSELVLSEDEKSDNEDKEETELGVMEDQRSIILHLISQLKLGMDLTKVVLPTFILEKRSLLEMYADFMAHPDLLLAITAGATPEERVICFVEYYLTAFHEGRKGALAKKPYNPIIGETFHCSWEVPKDRVKPKRTASRSPASCHEHPMADDPSKSYKLRFVAEQVSHHPPISCFYCECEEKRLCVNTHVWTKSKFMGMSVGVSMIGEGVLRLLEHGEEYVFTLPSAYARSILTIPWVELGGKVSINCAKTGYSATVIFHTKPFYGGKVHRVTAEVKHNPTNTIVCKAHGEWNGTLEFTYNNGETKVIDTTTLPVYPKKIRPLEKQGPMESRNLWREVTRYLRLGDIDAATEQKRHLEEKQRVEERKRENLRTPWKPKYFIQEGDGWVYFNPLWKAH
uniprot
proteins
function
FUNCTION: Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (Probable) (PubMed:23934110). Plays a role in negative regulation of lipid biosynthesis (PubMed:19554302). Interacts with OSBPL9 to function as lipid transfer proteins (PubMed:36853333). Together they form a heterodimer that localizes at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex (PubMed:36853333). Negatively regulates APOB secretion from hepatocytes (PubMed:19554302, PubMed:22906437). Binds cholesterol and acidic phospholipids (PubMed:22906437). Also binds 25-hydroxycholesterol (PubMed:17428193). Binds phosphatidylserine (PubMed:23934110). {ECO:0000269|PubMed:17428193, ECO:0000269|PubMed:19554302, ECO:0000269|PubMed:22906437, ECO:0000269|PubMed:23934110, ECO:0000269|PubMed:36853333, ECO:0000305}.
uniprot
proteins
mass_dalton
83970
uniprot
proteins
protein_family
OSBP family
uniprot
proteins
pubmed
11483621
uniprot
proteins
pubmed
11735225
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17428193
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19554302
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20224571
uniprot
proteins
pubmed
20610895
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22906437
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23325789
uniprot
proteins
pubmed
23934110
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
36853333
uniprot
proteins
sequence_length
764
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19554302, ECO:0000269|PubMed:22906437}. Late endosome membrane {ECO:0000269|PubMed:22906437}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:22906437}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:36853333}. Note=Associates with microtubules. Localizes at the Golgi-late endosome interface (PubMed:22906437). {ECO:0000269|PubMed:19554302, ECO:0000269|PubMed:22906437}.
uniprot
proteins