OAZ1
entrez
4946
canonical
uniprot
P54368
canonical
ensembl
ENSG00000104904
resolver
ensp
ENSP00000463955
resolver
ensp
ENSP00000473381
resolver
enst
ENST00000582888
resolver
enst
ENST00000602676
resolver
genesymbol
OAZ1
resolver
genesymbol_syn
OAZ
resolver
hgnc
HGNC:8095
resolver
uniprot
J3QQY4
resolver
uniprot
O43382
resolver
uniprot
Q14989
resolver
uniprot
Q92595
resolver
uniprot
Q9UPL9
resolver
uniprot_entry
J3QQY4_HUMAN
resolver
uniprot_entry
OAZ1_HUMAN
resolver
uniprot_sec
O43382
resolver
uniprot_sec
Q14989
resolver
uniprot_sec
Q92595
resolver
uniprot_sec
Q9UPL9
resolver
amino_acid_sequence
MVKSSLQRILNSHCFAREKEGDKPSATIHASRTMPLLSLHSRGGSSSESSRVSLHCCSNPGPGPRWCSDAPHPPLKIPGGRGNSQRDHNLSANLFYSDDRLNVTEELTSNDKTRILNVQSRLTDAKRINWRTVLSGGSLYIEIPGGALPEGSKDSFAVLLEFAEEQLRADHVFICFHKNREDRAALLRTFSFLGFEIVRPGHPLVPKRPDACFMAYTFERESSGEEEE
uniprot
proteins
function
FUNCTION: Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome (PubMed:17900240, PubMed:26305948, PubMed:26443277). Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC (PubMed:26305948). Stabilizes AZIN2 by interfering with its ubiquitination (PubMed:17900240). Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol (PubMed:12097147). {ECO:0000269|PubMed:12097147, ECO:0000269|PubMed:17900240, ECO:0000269|PubMed:26305948, ECO:0000269|PubMed:26443277}.
uniprot
proteins
mass_dalton
25406
uniprot
proteins
protein_family
ODC antizyme family
uniprot
proteins
pubmed
12097147
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
17900240
uniprot
proteins
pubmed
26305948
uniprot
proteins
pubmed
26443277
uniprot
proteins
pubmed
30312582
uniprot
proteins
pubmed
7811704
uniprot
proteins
pubmed
9132164
uniprot
proteins
pubmed
9426243
uniprot
proteins
sequence_length
228
uniprot
proteins