Kcnj12
entrez
16515
canonical
uniprot
P52187
canonical
ensembl
ENSMUSG00000042529
resolver
ensp
ENSMUSP00000041696
resolver
ensp
ENSMUSP00000086588
resolver
ensp
ENSMUSP00000104357
resolver
ensp
ENSMUSP00000196669
resolver
enst
ENSMUST00000041944
resolver
enst
ENSMUST00000089184
resolver
enst
ENSMUST00000108717
resolver
genesymbol
Kcnj12
resolver
genesymbol_syn
Irk2
resolver
uniprot
B1ATI1
resolver
uniprot
Q8CCR0
resolver
uniprot
Q9D3L6
resolver
uniprot
Q9QYF2
resolver
uniprot_entry
B1ATI1_MOUSE
resolver
uniprot_entry
KCJ12_MOUSE
resolver
uniprot_entry
Q9D3L6_MOUSE
resolver
uniprot_sec
Q8CCR0
resolver
uniprot_sec
Q9QYF2
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphatidylinositol 4,5-biphosphate (PtdIns(4,5)P2) (By similarity). PtdIns(4,5)P2 binding to the cytoplasmic side of the channel triggers a conformation change leading to channel opening (By similarity). Inhibited by Ba(2+) (PubMed:8083233). {ECO:0000250|UniProtKB:F1NHE9, ECO:0000250|UniProtKB:Q14500, ECO:0000269|PubMed:8083233}.
uniprot
proteins
amino_acid_sequence
MTAASRANPYSIVSSEEDGLHLVTMSGANGFGNGKVHTRRRCRNRFVKKNGQCNIEFANMDEKSQRYLADMFTTCVDIRWRYMLLIFSLAFLASWLLFGIIFWVIAVAHGDLEPAEGRGRTPCVLQVHGFMAAFLFSIETQTTIGYGLRCVTEECPVAVFMVVAQSIVGCIIDSFMIGAIMAKMARPKKRAQTLLFSHNAVVALRDGKLCLMWRVGNLRKSHIVEAHVRAQLIKPRVTEEGEYIPLDQIDIDVGFDKGLDRIFLVSPITILHEIDEASPLFGISRQDLETDDFEIVVILEGMVEATAMTTQARSSYLANEILWGHRFEPVLFEEKNQYKIDYSHFHKTYEVPSTPRCSAKDLVENKFLLPSANSFCYENELAFLSRDEEDEVATDRDGRSPQPEHDFDRLQASSAALERPYRRESEI
uniprot
proteins
function
FUNCTION: Inward rectifying potassium channel that probably participates in controlling the resting membrane potential in electrically excitable cells (By similarity). It probably participates in establishing action potential waveform and excitability of neuronal and muscle tissues (By similarity). Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. {ECO:0000250|UniProtKB:Q14500, ECO:0000269|PubMed:8083233}.
uniprot
proteins
mass_dalton
48427
uniprot
proteins
protein_family
Inward rectifier-type potassium channel (TC 1.A.2.1) family
uniprot
proteins
protein_family
KCNJ12 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
8083233
uniprot
proteins
sequence_length
427
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q14500}. Cell membrane, sarcolemma, T-tubule {ECO:0000250|UniProtKB:P52188}.
uniprot
proteins
transmembrane_region
TRANSMEM 78..104; /note="Helical; Name=M1"; /evidence="ECO:0000250|UniProtKB:F1NHE9"; TRANSMEM 156..183; /note="Helical; Name=M2"; /evidence="ECO:0000250|UniProtKB:F1NHE9
uniprot
proteins