Phf7
entrez
71838
canonical
uniprot
Q9DAG9
canonical
ensembl
ENSMUSG00000021902
resolver
ensp
ENSMUSP00000022459
resolver
ensp
ENSMUSP00000154095
resolver
ensp
ENSMUSP00000154281
resolver
ensp
ENSMUSP00000154738
resolver
ensp
ENSMUSP00000275653
resolver
ensp
ENSMUSP00000356909
resolver
enst
ENSMUST00000228437
resolver
enst
ENSMUST00000228930
resolver
genesymbol
Phf7
resolver
uniprot
A0A2I3BR08
resolver
uniprot
A0A2I3BRU7
resolver
uniprot
A2RTI5
resolver
uniprot
B7ZNN0
resolver
uniprot
Q6PG81
resolver
uniprot_entry
A0A2I3BR08_MOUSE
resolver
uniprot_entry
A0A2I3BRU7_MOUSE
resolver
uniprot_entry
A2RTI5_MOUSE
resolver
uniprot_entry
B7ZNN0_MOUSE
resolver
uniprot_entry
PHF7_MOUSE
resolver
uniprot_sec
Q6PG81
resolver
amino_acid_sequence
MKTLKEKNKHPRLRKTIRTKKVTQRKLSSSPVCLLCLQEPGDPEKLGEFLQKDNLCVHYFCLILSSRLPQKGQPNRGLHGFMPEDIKREAVRASKKICFVCKKKGAAIRCQNDQCVQNFHLPCGQERGCLSQFFGEYKSYCRKHRPTQNIHQGSLGEESCVLCCENLSRTSVENIQSPCCSQAIYHRKCIQKYAHTSAKHFFKCPQCNNREEFPQEMLRMGIHIPDRDAAWELEPGAFSELYQRYRHCDAPICLYEQGRDSFEDEGRWRLILCATCGSHGTHRDCSSLRPNSKKWECNECLPASTTS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase which ubiquitinates histone H3 at 'Lys-14' (PubMed:32726616). Required for male fertility, via inhibition of SPOP-mediated BRDT degradation when in the presence of acetylated histone H4 in early condensing spermatids (PubMed:32726616). Stabilization of BRDT allows it to facilitate histone removal in early condensing spermatids and promote the progression of histone-to-protamine exchange (PubMed:32726616). Promotes the expression of steroidogenesis proteins in the testes, and as a result plays a role in maintaining testosterone levels and repressing osteoclastogenesis (PubMed:38430697). Promotes transcription of cardiac enhancer genes by facilitating binding of cardiac transcription factors such as MEF2C and GATA4 to target gene promoters (PubMed:33941892). Ubiquitinates histone H4 (By similarity). Ubiquitinates histone H2A and H3 as part of the nucleosome core particle (PubMed:37993255). {ECO:0000250|UniProtKB:Q9BWX1, ECO:0000269|PubMed:32726616, ECO:0000269|PubMed:33941892, ECO:0000269|PubMed:37993255, ECO:0000269|PubMed:38430697}.
uniprot
proteins
mass_dalton
35381
uniprot
proteins
mutagenesis
MUTAGEN 44; /note="E->K: Reduces ubiquitination of histone H3."; /evidence="ECO:0000269|PubMed:37993255"; MUTAGEN 67; /note="R->A: Reduces interaction with and ubiquitination of the nucleosome core particle. No effect on ubiquitination of histone H3."; /evidence="ECO:0000269|PubMed:37993255"; MUTAGEN 71; /note="K->S: Reduces interaction with and ubiquitination of the nucleosome core particle. No effect on ubiquitination of histone H3."; /evidence="ECO:0000269|PubMed:37993255"; MUTAGEN 76; /note="R->S: Reduces interaction with and ubiquitination of the nucleosome core particle. No effect on ubiquitination of histone H3."; /evidence="ECO:0000269|PubMed:37993255"; MUTAGEN 87; /note="K->S: Abolishes interaction with and ubiquitination of the nucleosome core particle. No effect on ubiquitination of histone H3."; /evidence="ECO:0000269|PubMed:37993255"; MUTAGEN 88; /note="R->S: Abolishes interaction with and ubiquitination of the nucleosome core particle. No effect on ubiquitination of histone H3."; /evidence="ECO:0000269|PubMed:37993255"; MUTAGEN 92; /note="R->S: Abolishes interaction with and ubiquitination of the nucleosome core particle. No effect on ubiquitination of histone H3."; /evidence="ECO:0000269|PubMed:37993255"; MUTAGEN 148; /note="Q->A: Reduces ubiquitination of histone H3."; /evidence="ECO:0000269|PubMed:37993255"; MUTAGEN 160; /note="C->A: Fails to inhibit Spop-mediated ubiquitination and degradation of Brdt."; /evidence="ECO:0000269|PubMed:32726616"; MUTAGEN 181; /note="S->A: Abolishes ubiquitination of histone H3."; /evidence="ECO:0000269|PubMed:37993255"; MUTAGEN 206; /note="Q->A: Abolishes ubiquitination of histone H3."; /evidence="ECO:0000269|PubMed:37993255"; MUTAGEN 208; /note="N->A: Abolishes ubiquitination of histone H3."; /evidence="ECO:0000269|PubMed:37993255"; MUTAGEN 231; /note="W->A: Reduces interaction with UBE2D2."; /evidence="ECO:0000269|PubMed:37993255"; MUTAGEN 232; /note="E->R: Abolishes interaction with UBE2D2."; /evidence="ECO:0000269|PubMed:37993255"; MUTAGEN 238; /note="F->A: Reduces interaction with UBE2D2."; /evidence="ECO:0000269|PubMed:37993255"; MUTAGEN 242; /note="Y->A: Reduces interaction with UBE2D2."; /evidence="ECO:0000269|PubMed:37993255"; MUTAGEN 245; /note="Y->A: Reduces ubiquitination of histone H3."; /evidence="ECO:0000269|PubMed:37993255"; MUTAGEN 262; /note="F->A: Reduces ubiquitination of histone H3."; /evidence="ECO:0000269|PubMed:37993255"; MUTAGEN 270; /note="L->A: Reduces ubiquitination of histone H3."; /evidence="ECO:0000269|PubMed:37993255
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:32726616}.
uniprot
proteins
pubmed
11829468
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
32726616
uniprot
proteins
pubmed
33941892
uniprot
proteins
pubmed
37993255
uniprot
proteins
pubmed
38430697
uniprot
proteins
sequence_length
307
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9BWX1}.
uniprot
proteins