Mgat4d
entrez
67555
canonical
uniprot
Q9D4R2
canonical
ensembl
ENSMUSG00000035057
resolver
ensp
ENSMUSP00000041629
resolver
genesymbol
Mgat4d
resolver
uniprot
E2F697
resolver
uniprot
E9QM08
resolver
uniprot_entry
MGT4D_MOUSE
resolver
uniprot_sec
E2F697
resolver
uniprot_sec
E9QM08
resolver
amino_acid_sequence
MKAKNVNLLFAFVAVLLFGFSCFCISRMNQTNNQLINCRNHVLEFKEIMLRLKNKSENHHQDLMQVLYQMKRKAAHTTRSSGNFLEKKGSILSQHETLPNQFEVLKYFLPHLRTAGKLYPAIATSKGRAGVSFALGISTINRGNHTYLKQTLTSVLSRMTPEEEEDSVVIVSVADTDESYLKSVVRMVKTKFRKQVQSGVLEVISIPTLFYPQTLLDKKTKTDSESWQIKQVLDFCILMLYAQPKATYYLQLEDDIVAKKMYFTKMKDFVNSLTSKNWFFIEFSVLGFIGKLFRSKDLTDFVHFFLMFYETKPIDILLDDIFLIRVCISGEPVRSCLQRKKGFRIQYRPSLFQHVGTQSSFPGREQHLKDNYY
uniprot
proteins
function
FUNCTION: [Isoform 2]: May play a role in male spermatogenesis. In vitro acts as inhibitor of MGAT1 activity causing cell surface proteins to carry mainly high mannose N-glycans. The function is mediated by its lumenal domain and occurs specifically in the Golgi. A catalytic glucosyltransferase activity is not detected. May be involved in regulation of Sertoli-germ cell interactions during specific stages of spermatogenesis. {ECO:0000269|PubMed:20805325, ECO:0000269|PubMed:26371870}.
uniprot
proteins
mass_dalton
43300
uniprot
proteins
post_translational_modification
PTM: Isoform 2 is N-glycosylated; consisting of high-mannose and/or hybrid glycans. {ECO:0000269|PubMed:20805325}.
uniprot
proteins
protein_family
Glycosyltransferase 54 family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20805325
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26371870
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 2]: Endoplasmic reticulum membrane {ECO:0000269|PubMed:20805325}; Single-pass type II membrane protein {ECO:0000305|PubMed:20805325}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000269|PubMed:20805325}; Single-pass type II membrane protein {ECO:0000305|PubMed:20805325}. Golgi apparatus membrane {ECO:0000269|PubMed:20805325}; Single-pass type II membrane protein {ECO:0000305|PubMed:20805325}.; SUBCELLULAR LOCATION: [Isoform 1]: Golgi apparatus membrane {ECO:0000250|UniProtKB:Q4V8F8}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q4V8F8}.
uniprot
proteins
transmembrane_region
TRANSMEM 6..26; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins