COPS7B
entrez
64708
canonical
uniprot
Q9H9Q2
canonical
ensembl
ENSG00000144524
resolver
ensp
ENSP00000272995
resolver
ensp
ENSP00000362710
resolver
ensp
ENSP00000386438
resolver
ensp
ENSP00000386567
resolver
ensp
ENSP00000386880
resolver
ensp
ENSP00000484363
resolver
ensp
ENSP00000484579
resolver
ensp
ENSP00000546314
resolver
ensp
ENSP00000664391
resolver
ensp
ENSP00000754616
resolver
enst
ENST00000409295
resolver
enst
ENST00000410017
resolver
enst
ENST00000611614
resolver
enst
ENST00000876255
resolver
genesymbol
COPS7B
resolver
genesymbol_syn
CSN7B
resolver
hgnc
HGNC:16760
resolver
uniprot
A0A087X1P5
resolver
uniprot
J3KQ34
resolver
uniprot
J3KQ41
resolver
uniprot
Q53S22
resolver
uniprot
Q5BJG3
resolver
uniprot
Q6ZTQ7
resolver
uniprot
Q9H7V6
resolver
uniprot_entry
A0A087X1P5_HUMAN
resolver
uniprot_entry
CSN7B_HUMAN
resolver
uniprot_entry
J3KQ34_HUMAN
resolver
uniprot_entry
J3KQ41_HUMAN
resolver
uniprot_entry
Q6ZTQ7_HUMAN
resolver
uniprot_sec
Q53S22
resolver
uniprot_sec
Q5BJG3
resolver
uniprot_sec
Q9H7V6
resolver
amino_acid_sequence
MAGEQKPSSNLLEQFILLAKGTSGSALTALISQVLEAPGVYVFGELLELANVQELAEGANAAYLQLLNLFAYGTYPDYIANKESLPELSTAQQNKLKHLTIVSLASRMKCIPYSVLLKDLEMRNLRELEDLIIEAVYTDIIQGKLDQRNQLLEVDFCIGRDIRKKDINNIVKTLHEWCDGCEAVLLGIEQQVLRANQYKENHNRTQQQVEAEVTNIKKTLKATASSSAQEMEQQLAERECPPHAEQRQPTKKMSKVKGLVSSRH
uniprot
proteins
function
FUNCTION: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. {ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143}.
uniprot
proteins
mass_dalton
29622
uniprot
proteins
protein_family
CSN7 subfamily
uniprot
proteins
protein_family
CSN7/EIF3M family
uniprot
proteins
pubmed
11285227
uniprot
proteins
pubmed
11337588
uniprot
proteins
pubmed
12220626
uniprot
proteins
pubmed
12628923
uniprot
proteins
pubmed
12732143
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18850735
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
26456823
uniprot
proteins
pubmed
29444943
uniprot
proteins
sequence_length
264
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
uniprot
proteins