Gemin7
entrez
69731
canonical
uniprot
Q9CWY4
canonical
ensembl
ENSMUSG00000044709
resolver
ensp
ENSMUSP00000055844
resolver
ensp
ENSMUSP00000112742
resolver
ensp
ENSMUSP00000113266
resolver
ensp
ENSMUSP00000113583
resolver
ensp
ENSMUSP00000113709
resolver
enst
ENSMUST00000051364
resolver
enst
ENSMUST00000117222
resolver
enst
ENSMUST00000119912
resolver
enst
ENSMUST00000122055
resolver
enst
ENSMUST00000122127
resolver
genesymbol
Gemin7
resolver
uniprot_entry
GEMI7_MOUSE
resolver
amino_acid_sequence
MQSPLTIPVPVPVLRLPRGPDGFSRGFASDGRRTILRPEVGEGHIQDPPESQEQRARATLRERYLRSLLAMVGHPVSFTLHEGVHVTAQFGATDLDVANFYVSQLQTPIGVQAEALLRCSDIISYSFKL
uniprot
proteins
function
FUNCTION: The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP (By similarity). {ECO:0000250|UniProtKB:Q9H840}.
uniprot
proteins
mass_dalton
14251
uniprot
proteins
protein_family
Gemin-7 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
129
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q9H840}. Nucleus, gem {ECO:0000250|UniProtKB:Q9H840}. Cytoplasm {ECO:0000250|UniProtKB:Q9H840}. Note=Found both in the nucleoplasm and in nuclear bodies called gems (Gemini of Cajal bodies) that are often in proximity to Cajal (coiled) bodies. Also found in the cytoplasm (By similarity). {ECO:0000250}.
uniprot
proteins