Fzd9
entrez
14371
canonical
uniprot
Q9R216
canonical
ensembl
ENSMUSG00000049551
resolver
ensp
ENSMUSP00000053551
resolver
enst
ENSMUST00000062572
resolver
genesymbol
Fzd9
resolver
genesymbol_syn
Fzd3
resolver
uniprot
O35494
resolver
uniprot
Q9CX16
resolver
uniprot
Q9R2B3
resolver
uniprot_entry
FZD9_MOUSE
resolver
uniprot_sec
O35494
resolver
uniprot_sec
Q9CX16
resolver
uniprot_sec
Q9R2B3
resolver
amino_acid_sequence
MAVPPLLRGALLLWQLLATGGAALEIGRFDPERGRGPAPCQAMEIPMCRGIGYNLTRMPNLLGHTSQGEAAAQLAEFSPLVQYGCHSHLRFFLCSLYAPMCTDQVSTPIPACRPMCEQARLRCAPIMEQFNFGWPDSLDCARLPTRNDPHALCMEAPENATAGPTEPHKGLGMLPVAPRPARPPGDSAPGPGSGGTCDNPEKFQYVEKSRSCAPRCGPGVEVFWSRRDKDFALVWMAVWSALCFFSTAFTVFTFLLEPHRFQYPERPIIFLSMCYNVYSLAFLIRAVAGAQSVACDQEAGALYVIQEGLENTGCTLVFLLLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEAHGSYFHMAAWGLPALKTIVVLTLRKVAGDELTGLCYVASMDPAALTGFVLVPLSCYLVLGTSFLLTGFVALFHIRKIMKTGGTNTEKLEKLMVKIGVFSILYTVPATCVIVCYVYERLNMDFWRLRATEQPCTAATVPGGRRDCSLPGGSVPTVAVFMLKIFMSLVVGITSGVWVWSSKTFQTWQSLCYRKMAAGRARAKACRTPGGYGRGTHCHYKAPTVVLHMTKTDPSLENPTHL
uniprot
proteins
function
FUNCTION: Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). Plays a role in neuromuscular junction (NMJ) assembly by negatively regulating the clustering of acetylcholine receptors (AChR) through the beta-catenin canonical signaling pathway (PubMed:24860427). May play a role in neural progenitor cells (NPCs) viability through the beta-catenin canonical signaling pathway by negatively regulating cell cycle arrest leading to inhibition of neuron apoptotic process (By similarity). During hippocampal development, regulates neuroblast proliferation and apoptotic cell death (PubMed:15930120). Controls bone formation through non canonical Wnt signaling mediated via ISG15 (PubMed:21402791). Positively regulates bone regeneration through non canonical Wnt signaling (PubMed:24391920). {ECO:0000250|UniProtKB:O00144, ECO:0000250|UniProtKB:Q8K4C8, ECO:0000269|PubMed:15930120, ECO:0000269|PubMed:21402791, ECO:0000269|PubMed:24391920, ECO:0000269|PubMed:24860427}.
uniprot
proteins
mass_dalton
64995
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. {ECO:0000250}.
uniprot
proteins
protein_family
G protein-coupled receptor Fz/Smo family
uniprot
proteins
pubmed
10198163
uniprot
proteins
pubmed
15930120
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21402791
uniprot
proteins
pubmed
24391920
uniprot
proteins
pubmed
24860427
uniprot
proteins
sequence_length
592
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24860427}; Multi-pass membrane protein {ECO:0000255}. Note=Relocalizes DVL1 to the cell membrane leading to phosphorylation of DVL1 and AXIN1 relocalization to the cell membrane. {ECO:0000250|UniProtKB:Q8K4C8}.
uniprot
proteins
transmembrane_region
TRANSMEM 231..251; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 268..288; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 317..337; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 357..377; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 402..422; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 449..469; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 510..530; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins