Ddx39a
entrez
68278
canonical
uniprot
Q8VDW0
canonical
ensembl
ENSMUSG00000005481
resolver
ensp
ENSMUSP00000019576
resolver
ensp
ENSMUSP00000105435
resolver
genesymbol
Ddx39a
resolver
genesymbol_syn
Ddx39
resolver
uniprot
Q3UAF1
resolver
uniprot
Q3UJV4
resolver
uniprot
Q8C2C2
resolver
uniprot_entry
DX39A_MOUSE
resolver
uniprot_entry
Q3UAF1_MOUSE
resolver
uniprot_sec
Q3UJV4
resolver
uniprot_sec
Q8C2C2
resolver
amino_acid_sequence
MAEQDVENELLDYDEDEEPQAPQESTPAPPKKDVKGSYVSIHSSGFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLATLQQIEPVNGQVSVLVMCHTRELAFQISKEYERFSKYMPSVKVSVFFGGLSIKKDEDVLKKNCPHVVVGTPGRILALVRSRSLNLRNVKHFVLDECDKMLEQLDMRRDVQEIFRLTPHEKQCMMFSATLSKEIRPVCRKFMQDPMEVFVDDETKLTLHGLQQYYVKLKDSEKNRKLFDLLDVLEFNQVVIFVKSVQRCMALAQLLVEQNFPAIAIHRGMAQEERLSRYQQFKDFQRRILVATNLFGRGMDIERVNIVFNYDMPEDSDTYLHRVARAGRFGTKGLAVTFVSDENDAKILNDVQDRFEVNVAELPEEIDISTYIEQSR
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: Helicase that plays an essential role in mRNA export and is involved in multiple steps in RNA metabolism including alternative splicing. Regulates nuclear mRNA export to the cytoplasm through association with ECD. Also involved in spliceosomal uridine-rich small nuclear RNA (U snRNA) export by stimulating the RNA binding of adapter PHAX. Plays a role in the negative regulation of type I IFN production by increasing the nuclear retention of antiviral transcripts and thus reducing their protein expression. Independently of the interferon pathway, plays an antiviral role against alphaviruses by binding to a 5' conserved sequence element in the viral genomic RNA. {ECO:0000250|UniProtKB:O00148}.
uniprot
proteins
mass_dalton
49067
uniprot
proteins
post_translational_modification
PTM: SUMOylated by RANBP2; SUMOylation modification affects its ability to bind RNA. {ECO:0000250|UniProtKB:O00148}.
uniprot
proteins
protein_family
DEAD box helicase family
uniprot
proteins
protein_family
DECD subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
427
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O00148}. Cytoplasm {ECO:0000250|UniProtKB:O00148}. Note=Can translocate to the cytoplasm in the presence of MX1. Accumulates in the cytoplasm upon infection with chikungunya virus. {ECO:0000250|UniProtKB:O00148}.
uniprot
proteins