CENPU
entrez
79682
canonical
uniprot
Q71F23
canonical
ensembl
ENSG00000151725
resolver
ensp
ENSP00000281453
resolver
ensp
ENSP00000423248
resolver
genesymbol
CENPU
resolver
genesymbol_syn
ICEN24
resolver
genesymbol_syn
KLIP1
resolver
genesymbol_syn
MLF1IP
resolver
genesymbol_syn
PBIP1
resolver
hgnc
HGNC:21348
resolver
uniprot
A2RRD9
resolver
uniprot
Q09GN2
resolver
uniprot
Q32Q71
resolver
uniprot
Q9H5G1
resolver
uniprot_entry
CENPU_HUMAN
resolver
uniprot_sec
A2RRD9
resolver
uniprot_sec
Q09GN2
resolver
uniprot_sec
Q32Q71
resolver
uniprot_sec
Q9H5G1
resolver
amino_acid_sequence
MAPRGRRRPRPHRSEGARRSKNTLERTHSMKDKAGQKCKPIDVFDFPDNSDVSSIGRLGENEKDEETYETFDPPLHSTAIYADEEEFSKHCGLSLSSTPPGKEAKRSSDTSGNEASEIESVKISAKKPGRKLRPISDDSESIEESDTRRKVKSAEKISTQRHEVIRTTASSELSEKPAESVTSKKTGPLSAQPSVEKENLAIESQSKTQKKGKISHDKRKKSRSKAIGSDTSDIVHIWCPEGMKTSDIKELNIVLPEFEKTHLEHQQRIESKVCKAAIATFYVNVKEQFIKMLKESQMLTNLKRKNAKMISDIEKKRQRMIEVQDELLRLEPQLKQLQTKYDELKERKSSLRNAAYFLSNLKQLYQDYSDVQAQEPNVKETYDSSSLPALLFKARTLLGAESHLRNINHQLEKLLDQG
uniprot
proteins
function
FUNCTION: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression. {ECO:0000269|PubMed:12941884, ECO:0000269|PubMed:16716197, ECO:0000269|PubMed:17081991}.
uniprot
proteins
mass_dalton
47522
uniprot
proteins
mutagenesis
MUTAGEN 77; /note="S->A: Insensitive to PLK1-induced degradation."; /evidence="ECO:0000269|PubMed:17081991"; MUTAGEN 78; /note="T->A: Insensitive to PLK1-induced degradation."; /evidence="ECO:0000269|PubMed:17081991"; MUTAGEN 78; /note="T->D: Failed to enhance the PLK1-dependent degradation."; /evidence="ECO:0000269|PubMed:17081991"; MUTAGEN 78; /note="T->E: Failed to enhance the PLK1-dependent degradation."; /evidence="ECO:0000269|PubMed:17081991
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PLK1 at Thr-78, creating a self-tethering site that specifically interacts with the polo-box domain of PLK1. {ECO:0000269|PubMed:17081991}.
uniprot
proteins
protein_family
CENP-U/AME1 family
uniprot
proteins
pubmed
12941884
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15116101
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
15893739
uniprot
proteins
pubmed
16622419
uniprot
proteins
pubmed
16622420
uniprot
proteins
pubmed
16716197
uniprot
proteins
pubmed
17081991
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
28112733
uniprot
proteins
sequence_length
418
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Chromosome, centromere, kinetochore. Note=Localizes in the kinetochore domain of centromeres. Colocalizes with PLK1 at the interzone between the inner and the outer kinetochore plates.
uniprot
proteins