SKP1
entrez
6500
canonical
uniprot
P63208
canonical
ensembl
ENSG00000113558
resolver
ensp
ENSP00000231487
resolver
ensp
ENSP00000429472
resolver
genesymbol
SKP1
resolver
genesymbol_syn
EMC19
resolver
genesymbol_syn
OCP2
resolver
genesymbol_syn
SKP1A
resolver
genesymbol_syn
TCEB1L
resolver
hgnc
HGNC:10899
resolver
uniprot
D3DQ97
resolver
uniprot
D3DQ98
resolver
uniprot
P34991
resolver
uniprot
Q8TAY2
resolver
uniprot_entry
SKP1_HUMAN
resolver
uniprot_sec
D3DQ97
resolver
uniprot_sec
D3DQ98
resolver
uniprot_sec
P34991
resolver
uniprot_sec
Q8TAY2
resolver
activity_regulation
ACTIVITY REGULATION: In oocytes and preimplantation embryos, SCF ubiquitin ligase complexes are maintained inactive by cytoplasmic lattices. {ECO:0000250|UniProtKB:Q9WTX5}.
uniprot
proteins
amino_acid_sequence
MPSIKLQSSDGEIFEVDVEIAKQSVTIKTMLEDLGMDDEGDDDPVPLPNVNAAILKKVIQWCTHHKDDPPPPEDDENKEKRTDDIPVWDQEFLKVDQGTLFELILAANYLDIKGLLDVTCKTVANMIKGKTPEEIRKTFNIKNDFTEEEEAQVRKENQWCEEK
uniprot
proteins
function
FUNCTION: Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5, CEP68 and probably NFKB2 (PubMed:25704143). SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) directs ubiquitination of BCL6 and DTL but does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(CCNF) directs ubiquitination of CCP110. SCF(FBXL3) and SCF(FBXL21) direct ubiquitination of CRY1 and CRY2. SCF(FBXO9) directs ubiquitination of TTI1 and TELO2. SCF(FBXO10) directs ubiquitination of BCL2. Core component of the Cul7-RING(FBXW8) ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:35982156). Also acts as a core component of the Cul1-RING(FBXL4) ubiquitin ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of BNIP3 and BNI3L (PubMed:36896912). {ECO:0000269|PubMed:16209941, ECO:0000269|PubMed:20181953, ECO:0000269|PubMed:22113614, ECO:0000269|PubMed:23431138, ECO:0000269|PubMed:25704143, ECO:0000269|PubMed:28727686, ECO:0000269|PubMed:35982156, ECO:0000269|PubMed:36896912}.
uniprot
proteins
mass_dalton
18658
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Undergoes autophagy-mediated degradation in the liver in a time-dependent manner. {ECO:0000250|UniProtKB:Q9WTX5}.
uniprot
proteins
protein_family
SKP1 family
uniprot
proteins
pubmed
11099048
uniprot
proteins
pubmed
11389839
uniprot
proteins
pubmed
11961546
uniprot
proteins
pubmed
12481031
uniprot
proteins
pubmed
12820959
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16209941
uniprot
proteins
pubmed
16880511
uniprot
proteins
pubmed
17389369
uniprot
proteins
pubmed
17434132
uniprot
proteins
pubmed
18203720
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20181953
uniprot
proteins
pubmed
20596027
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22113614
uniprot
proteins
pubmed
23431138
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25114211
uniprot
proteins
pubmed
25503564
uniprot
proteins
pubmed
25704143
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27568929
uniprot
proteins
pubmed
28727686
uniprot
proteins
pubmed
29149593
uniprot
proteins
pubmed
29444943
uniprot
proteins
pubmed
30033217
uniprot
proteins
pubmed
31209342
uniprot
proteins
pubmed
31413110
uniprot
proteins
pubmed
35982156
uniprot
proteins
pubmed
36896912
uniprot
proteins
pubmed
38342987
uniprot
proteins
pubmed
39880951
uniprot
proteins
pubmed
7553852
uniprot
proteins
pubmed
8530064
uniprot
proteins
pubmed
9031623
uniprot
proteins
sequence_length
163
uniprot
proteins