GMPR2
entrez
51292
canonical
uniprot
Q9P2T1
canonical
ensembl
ENSG00000100938
resolver
ensembl
ENSG00000284752
resolver
ensp
ENSP00000347449
resolver
ensp
ENSP00000382369
resolver
ensp
ENSP00000392859
resolver
ensp
ENSP00000405743
resolver
ensp
ENSP00000453299
resolver
ensp
ENSP00000454038
resolver
ensp
ENSP00000495732
resolver
ensp
ENSP00000565757
resolver
ensp
ENSP00000565758
resolver
enst
ENST00000557854
resolver
enst
ENST00000646201
resolver
genesymbol
GMPR2
resolver
genesymbol_syn
GMPR
resolver
hgnc
HGNC:4377
resolver
uniprot
D3DS66
resolver
uniprot
H0YNJ6
resolver
uniprot
Q567T0
resolver
uniprot
Q6IAJ8
resolver
uniprot
Q6PKC0
resolver
uniprot
Q86T14
resolver
uniprot_entry
GMPR2_HUMAN
resolver
uniprot_entry
H0YNJ6_HUMAN
resolver
uniprot_entry
Q6PKC0_HUMAN
resolver
uniprot_sec
D3DS66
resolver
uniprot_sec
Q567T0
resolver
uniprot_sec
Q6IAJ8
resolver
uniprot_sec
Q86T14
resolver
amino_acid_sequence
MPHIDNDVKLDFKDVLLRPKRSTLKSRSEVDLTRSFSFRNSKQTYSGVPIIAANMDTVGTFEMAKVLCKFSLFTAVHKHYSLVQWQEFAGQNPDCLEHLAASSGTGSSDFEQLEQILEAIPQVKYICLDVANGYSEHFVEFVKDVRKRFPQHTIMAGNVVTGEMVEELILSGADIIKVGIGPGSVCTTRKKTGVGYPQLSAVMECADAAHGLKGHIISDGGCSCPGDVAKAFGAGADFVMLGGMLAGHSESGGELIERDGKKYKLFYGMSSEMAMKKYAGGVAEYRASEGKTVEVPFKGDVEHTIRDILGGIRSTCTYVGAAKLKELSRRTTFIRVTQQVNPIFSEAC
uniprot
proteins
ec_number
1.7.1.7
uniprot
proteins
function
FUNCTION: Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (PubMed:12009299, PubMed:12669231, PubMed:16359702, PubMed:22037469). Plays a role in modulating cellular differentiation (PubMed:12669231). {ECO:0000255|HAMAP-Rule:MF_03195, ECO:0000269|PubMed:12009299, ECO:0000269|PubMed:12669231, ECO:0000269|PubMed:16359702, ECO:0000269|PubMed:22037469}.
uniprot
proteins
mass_dalton
37874
uniprot
proteins
mutagenesis
MUTAGEN 186; /note="C->A: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:16359702, ECO:0000269|PubMed:22037469"; MUTAGEN 188; /note="T->A: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:22037469"; MUTAGEN 289; /note="E->Q: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:22037469
uniprot
proteins
protein_family
GuaC type 1 subfamily
uniprot
proteins
protein_family
IMPDH/GMPR family
uniprot
proteins
pubmed
12009299
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
12669231
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16359702
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22037469
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
348
uniprot
proteins