Preb
entrez
58842
canonical
uniprot
Q9WTV0
canonical
ensembl
ENSRNOG00000007141
resolver
ensp
ENSRNOP00000009566
resolver
genesymbol
Preb
resolver
genesymbol_syn
Sec12
resolver
uniprot
Q6AYS1
resolver
uniprot_entry
SEC12_RAT
resolver
uniprot_sec
Q6AYS1
resolver
amino_acid_sequence
MGRRRGVELYRAPFPLYALRIDPKTGLLIAAGGGGAAKTGIKNGVHFLQLEQISGCLSASLLHSHDTETRATMNLALAGDILAAGQDAQCQLLRFQIHQQKGSKAEKSGSKEQGPRQRKGAAPAEKKSGAEVHPEGVELKVKNLEAVQTDFSTEPLQKVVCFNHDNTLLATGGSDGHVRVWKVPSLEKVLEFKAHEGEIGDLALGPDGKLVTVGWDFKASVWQKDQLVTQLQWQENGPTSSNTPYRYQACRFGQVPDQPGGLRLFTVQIPHKRLRQPPPCYLTAWDSSTFLPLQTRSCGHEVISCLTVSESGTFLGLGTVTGSVAIYIAFSLQRLYYVKEAHGIVVTDVTFLPEKGCGPKLLGPHETALFSVAVDSRCQLHLLPSRRSVPVWLLLLLCVGLIIVTILLLQSAFPGFL
uniprot
proteins
function
FUNCTION: Guanine nucleotide exchange factor (GEF) that regulates the assembly of the coat protein complex II/COPII in endoplasmic reticulum (ER) to Golgi vesicle-mediated transport. Selectively activates SAR1A and SAR1B by promoting the exchange of guanosine diphosphate (GDP) for guanosine triphosphate (GTP) in these small GTPases (PubMed:11422940). In their activated GTP-bound state, SAR1A and SAR1B insert into the membrane of the endoplasmic reticulum where they recruit the remainder of the coat protein complex II/COPII which is responsible for both the sorting of proteins and the deformation and budding of membranes into vesicles destined to the Golgi (PubMed:11422940). {ECO:0000269|PubMed:11422940}.; FUNCTION: Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription. {ECO:0000269|PubMed:10194769}.
uniprot
proteins
mass_dalton
45357
uniprot
proteins
pubmed
10194769
uniprot
proteins
pubmed
11422940
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
417
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:11422940}; Single-pass membrane protein {ECO:0000269|PubMed:11422940}. Nucleus {ECO:0000269|PubMed:10194769}. Note=Concentrates at endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). {ECO:0000250|UniProtKB:Q9HCU5}.
uniprot
proteins
transmembrane_region
TRANSMEM 389..409; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins