C5AR2
entrez
27202
canonical
uniprot
Q9P296
canonical
ensembl
ENSG00000134830
resolver
ensp
ENSP00000471184
resolver
ensp
ENSP00000472620
resolver
ensp
ENSP00000544317
resolver
enst
ENST00000595464
resolver
enst
ENST00000600626
resolver
enst
ENST00000874258
resolver
genesymbol
C5AR2
resolver
genesymbol_syn
C5L2
resolver
genesymbol_syn
GPR77
resolver
hgnc
HGNC:4527
resolver
uniprot
B2RA09
resolver
uniprot_entry
C5AR2_HUMAN
resolver
uniprot_sec
B2RA09
resolver
amino_acid_sequence
MGNDSVSYEYGDYSDLSDRPVDCLDGACLAIDPLRVAPLPLYAAIFLVGVPGNAMVAWVAGKVARRRVGATWLLHLAVADLLCCLSLPILAVPIARGGHWPYGAVGCRALPSIILLTMYASVLLLAALSADLCFLALGPAWWSTVQRACGVQVACGAAWTLALLLTVPSAIYRRLHQEHFPARLQCVVDYGGSSSTENAVTAIRFLFGFLGPLVAVASCHSALLCWAARRCRPLGTAIVVGFFVCWAPYHLLGLVLTVAAPNSALLARALRAEPLIVGLALAHSCLNPMLFLYFGRAQLRRSLPAACHWALRESQGQDESVDSKKSTSHDLVSEMEV
uniprot
proteins
function
FUNCTION: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a, stimulating chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production (PubMed:11773063). Also acts as a receptor for dearginated forms of C3a, C4a and C5a anaphylatoxin peptides (ASP/C3adesArg, C4adesArg and C5adesArg, respectively) (PubMed:12540846, PubMed:15833747, PubMed:19615750). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:12540846). C5AR1 is coupled to G(i)/G(o) (GNAI1 or GNAO1) G alpha proteins and mediates inhibition of adenylate cyclase (PubMed:12540846). {ECO:0000269|PubMed:11773063, ECO:0000269|PubMed:12540846, ECO:0000269|PubMed:15833747, ECO:0000269|PubMed:19615750}.
uniprot
proteins
mass_dalton
36080
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11090875
uniprot
proteins
pubmed
11165367
uniprot
proteins
pubmed
11773063
uniprot
proteins
pubmed
12540846
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15833747
uniprot
proteins
pubmed
16627811
uniprot
proteins
pubmed
19615750
uniprot
proteins
pubmed
21698200
uniprot
proteins
sequence_length
337
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19615750}; Multi-pass membrane protein {ECO:0000269|PubMed:19615750}.
uniprot
proteins
transmembrane_region
TRANSMEM 39..61; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 73..95; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 115..137; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 150..172; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 203..225; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 238..260; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 275..294; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins