Casq1
entrez
686019
canonical
uniprot
P19633
canonical
ensembl
ENSRNOG00000006930
resolver
ensembl
ENSRNOG00055021713
resolver
ensembl
ENSRNOG00060021516
resolver
ensembl
ENSRNOG00065026007
resolver
ensp
ENSRNOP00000009344
resolver
ensp
ENSRNOP00055030267
resolver
ensp
ENSRNOP00060030769
resolver
ensp
ENSRNOP00065036719
resolver
enst
ENSRNOT00055037180
resolver
enst
ENSRNOT00060037296
resolver
enst
ENSRNOT00065044825
resolver
genesymbol
Casq1
resolver
uniprot_entry
CASQ1_RAT
resolver
amino_acid_sequence
MRATDRMGARAVSKLRLALLFVLVLGTPRSGVQGEDGLDFPEYDGVDRVINVNAKNYKNVFKKYEVLALLYHEPPEDDKASQRQFEMEELILELAAQVLEDKGVGFGLVDSEKDAAVAKKLGLTEEDSVYVFKGDEVIEYDGEFSADTLVEFLLDVLEDPVELIEGERELQAFENIEDEIKLIGYFKSKDSEHYKAYEDAAEEFHPYIPFFATFDSKVAKKLTLKLNEIDFYEAFMEEPVTIPDKPNSEEEIVSFVEEHRRSTLRKLKPESMYETWEDDLDGIHIVAFAEEADPDGYEFLETLKAVAQDNTENPDLSIIWIDPDDFPLLVPYWEKTFDIDLSAPQIGVVNVTDADSIWMEMDDEEDLPSAEELEDWLEDVLEGEINTEDDDDDDDDDDDDDDDDDD
uniprot
proteins
function
FUNCTION: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle (PubMed:8042990). Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction (By similarity). Negatively regulates store-operated Ca(2+) entry (SOCE) activity (By similarity). {ECO:0000250|UniProtKB:O09165, ECO:0000250|UniProtKB:P07221, ECO:0000250|UniProtKB:P31415, ECO:0000269|PubMed:8042990}.
uniprot
proteins
mass_dalton
46449
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:P07221}.
uniprot
proteins
protein_family
Calsequestrin family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
3417768
uniprot
proteins
pubmed
8042990
uniprot
proteins
sequence_length
406
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:P31415}. Sarcoplasmic reticulum {ECO:0000250|UniProtKB:P31415}. Sarcoplasmic reticulum lumen {ECO:0000250|UniProtKB:P07221}. Sarcoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side {ECO:0000250|UniProtKB:P07221}. Mitochondrion matrix {ECO:0000250|UniProtKB:O09165}. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of fast skeletal muscle cells. Preferentially forms linear and round aggregates in the endoplasmic reticulum (ER) of resting cells. In a minority of cells, homogeneously detected in the ER lumen. Colocalizes with STIM1 at endoplasmic reticulum in response to a depletion of intracellular calcium. {ECO:0000250|UniProtKB:P07221, ECO:0000250|UniProtKB:P31415}.
uniprot
proteins