CYGB
entrez
114757
canonical
uniprot
Q8WWM9
canonical
ensembl
ENSG00000161544
resolver
ensp
ENSP00000293230
resolver
ensp
ENSP00000718831
resolver
enst
ENST00000293230
resolver
genesymbol
CYGB
resolver
genesymbol_syn
STAP
resolver
hgnc
HGNC:16505
resolver
uniprot
Q541Y7
resolver
uniprot
Q8N2X5
resolver
uniprot_entry
CYGB_HUMAN
resolver
uniprot_sec
Q541Y7
resolver
uniprot_sec
Q8N2X5
resolver
activity_regulation
ACTIVITY REGULATION: The nitric oxide dioxygenase activity is activated by a reducing system composed of cytochrome b5, its upstream reductase CYB5R3 and NADH. {ECO:0000269|PubMed:28671819}.
uniprot
proteins
amino_acid_sequence
MEKVPGEMEIERRERSEELSEAERKAVQAMWARLYANCEDVGVAILVRFFVNFPSAKQYFSQFKHMEDPLEMERSPQLRKHACRVMGALNTVVENLHDPDKVSSVLALVGKAHALKHKVEPVYFKILSGVILEVVAEEFASDFPPETQRAWAKLRGLIYSHVTAAYKEVGWVQQVPNATTPPATLPSSGP
uniprot
proteins
ec_number
1.11.1.-
uniprot
proteins
ec_number
1.14.12.-
uniprot
proteins
ec_number
1.15.1.1
uniprot
proteins
ec_number
1.7.-.-
uniprot
proteins
function
FUNCTION: Probable multifunctional globin with a hexacoordinated heme iron required for the catalysis of various reactions depending on redox condition of the cell as well as oxygen availability (PubMed:11893755, PubMed:12359339, PubMed:15165856, PubMed:19147491, PubMed:20511233, PubMed:28393874, PubMed:28671819, PubMed:29128400, PubMed:33576020, PubMed:34930834). Has a nitric oxide dioxygenase (NOD) activity and is most probably involved in cell-mediated and oxygen-dependent nitric oxide consumption (PubMed:19147491, PubMed:20511233, PubMed:28393874, PubMed:28671819). By scavenging this second messenger may regulate several biological processes including endothelium-mediated vasodilation and vascular tone (PubMed:19147491, PubMed:28393874). Under normoxic conditions functions as a nitric oxide dioxygenase (NOD) but under hypoxic conditions the globin may switch its function to that of a nitrite (NO2) reductase (NiR), generating nitric oxide (PubMed:29128400). Could also have peroxidase and superoxide dismutase activities, detoxifying reactive oxygen species and protecting cells against oxidative stress (PubMed:12359339, PubMed:33576020, PubMed:34930834). Also binds dioxygen with low affinity and could function as an oxygen sensor but has probably no function as a respiratory oxygen carrier (PubMed:11893755, PubMed:15299006, PubMed:20553503). {ECO:0000269|PubMed:11893755, ECO:0000269|PubMed:12359339, ECO:0000269|PubMed:15165856, ECO:0000269|PubMed:15299006, ECO:0000269|PubMed:19147491, ECO:0000269|PubMed:20511233, ECO:0000269|PubMed:20553503, ECO:0000269|PubMed:28393874, ECO:0000269|PubMed:28671819, ECO:0000269|PubMed:29128400, ECO:0000269|PubMed:33576020, ECO:0000269|PubMed:34930834}.
uniprot
proteins
mass_dalton
21405
uniprot
proteins
mutagenesis
MUTAGEN 38; /note="C->R: Decreased nitrite reductase activity; when associated with R-83."; /evidence="ECO:0000269|PubMed:29128400"; MUTAGEN 38; /note="C->S: Loss of interchain disulfide bond and loss of solubility but no effect on homodimerization; when associated with S-83."; /evidence="ECO:0000269|PubMed:15095869, ECO:0000269|PubMed:15165856"; MUTAGEN 83; /note="C->R: Decreased nitrite reductase activity; when associated with R-38."; /evidence="ECO:0000269|PubMed:29128400"; MUTAGEN 83; /note="C->S: Loss of interchain disulfide bond and loss of solubility but no effect on homodimerization; when associated with S-38."; /evidence="ECO:0000269|PubMed:15095869
uniprot
proteins
post_translational_modification
PTM: The formation of an intramolecular disulfide bond between cysteines Cys-38 and Cys-83 specifically enhances the nitrite reductase activity. {ECO:0000269|PubMed:29128400}.
uniprot
proteins
protein_family
Globin family
uniprot
proteins
pubmed
11893755
uniprot
proteins
pubmed
11919282
uniprot
proteins
pubmed
12359339
uniprot
proteins
pubmed
14660570
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15044115
uniprot
proteins
pubmed
15095869
uniprot
proteins
pubmed
15165856
uniprot
proteins
pubmed
15299006
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16699195
uniprot
proteins
pubmed
19147491
uniprot
proteins
pubmed
20511233
uniprot
proteins
pubmed
20553503
uniprot
proteins
pubmed
28393874
uniprot
proteins
pubmed
28671819
uniprot
proteins
pubmed
29128400
uniprot
proteins
pubmed
33576020
uniprot
proteins
pubmed
34930834
uniprot
proteins
sequence_length
190
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14660570, ECO:0000269|PubMed:34930834}. Nucleus {ECO:0000269|PubMed:14660570}.
uniprot
proteins