INPP5A
entrez
3632
canonical
uniprot
Q14642
canonical
ensembl
ENSG00000068383
resolver
ensp
ENSP00000357583
resolver
ensp
ENSP00000607769
resolver
ensp
ENSP00000637914
resolver
ensp
ENSP00000637917
resolver
ensp
ENSP00000792141
resolver
enst
ENST00000368594
resolver
enst
ENST00000937710
resolver
enst
ENST00000967855
resolver
enst
ENST00000967858
resolver
genesymbol
INPP5A
resolver
genesymbol_syn
5PTASE
resolver
hgnc
HGNC:6076
resolver
uniprot
D3DXI3
resolver
uniprot
Q14640
resolver
uniprot
Q5JSF1
resolver
uniprot_entry
I5P1_HUMAN
resolver
uniprot_sec
D3DXI3
resolver
uniprot_sec
Q14640
resolver
uniprot_sec
Q5JSF1
resolver
amino_acid_sequence
MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVVHTHKPHFMALHCQEFGGKNYEASMSHVDKFVKELLSSDAMKEYNRARVYLDENYKSQEHFTALGSFYFLHESLKNIYQFDFKAKKYRKVAGKEIYSDTLESTPMLEKEKFPQDYFPECKWSRKGFIRTRWCIADCAFDLVNIHLFHDASNLVAWETSPSVYSGIRHKALGYVLDRIIDQRFEKVSYFVFGDFNFRLDSKSVVETLCTKATMQTVRAADTNEVVKLIFRESDNDRKVMLQLEKKLFDYFNQEVFRDNNGTALLEFDKELSVFKDRLYELDISFPPSYPYSEDARQGEQYMNTRCPAWCDRILMSPSAKELVLRSESEEKVVTYDHIGPNVCMGDHKPVFLAFRIMPGAGKPHAHVHKCCVVQ
uniprot
proteins
ec_number
3.1.3.56
uniprot
proteins
function
FUNCTION: Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate (PubMed:40969890, PubMed:8013665, PubMed:8626616, PubMed:8769125). Plays a crucial role in the survival of cerebellar Purkinje cells (By similarity). {ECO:0000250|UniProtKB:Q7TNC9, ECO:0000269|PubMed:40969890, ECO:0000269|PubMed:8013665, ECO:0000269|PubMed:8626616, ECO:0000269|PubMed:8769125}.
uniprot
proteins
mass_dalton
47820
uniprot
proteins
mutagenesis
MUTAGEN 408..412; /note="Missing: Loss of membrane localization. No loss of enzyme activity."; /evidence="ECO:0000269|PubMed:8626616"; MUTAGEN 409; /note="C->S: Loss of prenylation and membrane localization. No loss of enzyme activity."; /evidence="ECO:0000269|PubMed:8626616
uniprot
proteins
post_translational_modification
PTM: Isoprenylation at Cys-409 is required for localization at the membrane. {ECO:0000269|PubMed:8626616}.
uniprot
proteins
protein_family
4
uniprot
proteins
protein_family
5-trisphosphate 5-phosphatase type I family
uniprot
proteins
protein_family
Inositol 1
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
40969890
uniprot
proteins
pubmed
8006039
uniprot
proteins
pubmed
8013665
uniprot
proteins
pubmed
8626616
uniprot
proteins
pubmed
8769125
uniprot
proteins
sequence_length
412
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8626616, ECO:0000305|PubMed:8006039}; Lipid-anchor {ECO:0000269|PubMed:8626616, ECO:0000305}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q7TNC9}.
uniprot
proteins