Adra2a
entrez
25083
canonical
uniprot
P22909
canonical
ensembl
ENSRNOG00000047545
resolver
ensembl
ENSRNOG00055028819
resolver
ensembl
ENSRNOG00060016882
resolver
ensembl
ENSRNOG00065010837
resolver
ensp
ENSRNOP00000066242
resolver
ensp
ENSRNOP00055041101
resolver
ensp
ENSRNOP00060023231
resolver
ensp
ENSRNOP00065013499
resolver
enst
ENSRNOT00000071541
resolver
enst
ENSRNOT00055049903
resolver
enst
ENSRNOT00060028861
resolver
enst
ENSRNOT00065017573
resolver
genesymbol
Adra2a
resolver
uniprot
M0R9R3
resolver
uniprot_entry
ADA2A_RAT
resolver
uniprot_sec
M0R9R3
resolver
amino_acid_sequence
MFRQEQPLAEGSFAPMGSLQPDAGNSSWNGTEAPGGGTRATPYSLQVTLTLVCLAGLLMLFTVFGNVLVIIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVMGYWYFGKVWCEIYLALDVLFCTSSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIVTVWVISAVISFPPLISIEKKGAGGGQQPAEPSCKINDQKWYVISSSIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRGPDACSAPPGGADRRPNGLGPERGAGTAGAEAEPLPTQLNGAPGEPAPTRPRDGDALDLEESSSSEHAERPQGPGKPERGPRAKGKTKASQVKPGDSLPRRGPGAAGPGASGSGQGEERAGGAKASRWRGRQNREKRFTFVLAVVIGVFVVCWFPFFFTYTLIAVGCPVPYQLFNFFFWFGYCNSSLNPVIYTIFNHDFRRAFKKILCRGDRKRIV
uniprot
proteins
function
FUNCTION: Alpha-2 adrenergic receptors are G protein-coupled receptors for catecholamines that activate the G(i/o) protein pathway, thereby promoting adenylyl cyclase inhibition, ERK1/2 stimulation, and voltage-gated calcium channels suppression (PubMed:15213003). ADRA2A and ADRA2C mediates the presynaptic feedback inhibition of neurotransmitter release from noradrenergic nerve terminals in sympathetic and central nervous systems. ADRA2A inhibits transmitter release at high stimulation frequencies, whereas ADRA2C modulates neurotransmission at lower levels of nerve activity (By similarity). {ECO:0000250|UniProtKB:Q01338, ECO:0000269|PubMed:15213003}.
uniprot
proteins
mass_dalton
50630
uniprot
proteins
protein_family
ADRA2A sub-subfamily
uniprot
proteins
protein_family
Adrenergic receptor subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15213003
uniprot
proteins
pubmed
1645350
uniprot
proteins
pubmed
2177834
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7623790
uniprot
proteins
sequence_length
465
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P08913}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P08913}.
uniprot
proteins
transmembrane_region
TRANSMEM 48..71; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P08913"; TRANSMEM 86..107; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P08913"; TRANSMEM 121..144; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P08913"; TRANSMEM 168..181; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P08913"; TRANSMEM 209..232; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P08913"; TRANSMEM 389..413; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P08913"; TRANSMEM 422..443; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P08913
uniprot
proteins