Chst1
entrez
295934
canonical
uniprot
Q5RJQ0
canonical
ensembl
ENSRNOG00000007989
resolver
ensembl
ENSRNOG00055016771
resolver
ensembl
ENSRNOG00060002936
resolver
ensembl
ENSRNOG00065024784
resolver
ensp
ENSRNOP00000010510
resolver
ensp
ENSRNOP00000079857
resolver
ensp
ENSRNOP00000081989
resolver
ensp
ENSRNOP00000086161
resolver
ensp
ENSRNOP00000087464
resolver
ensp
ENSRNOP00000090213
resolver
ensp
ENSRNOP00000100625
resolver
ensp
ENSRNOP00000104653
resolver
ensp
ENSRNOP00000106031
resolver
ensp
ENSRNOP00000108905
resolver
ensp
ENSRNOP00055022907
resolver
ensp
ENSRNOP00055022911
resolver
ensp
ENSRNOP00055022914
resolver
ensp
ENSRNOP00055022921
resolver
ensp
ENSRNOP00055022922
resolver
ensp
ENSRNOP00055022927
resolver
ensp
ENSRNOP00060003423
resolver
ensp
ENSRNOP00060003427
resolver
ensp
ENSRNOP00060003429
resolver
ensp
ENSRNOP00060003430
resolver
ensp
ENSRNOP00060003433
resolver
ensp
ENSRNOP00060003434
resolver
ensp
ENSRNOP00065034805
resolver
ensp
ENSRNOP00065034811
resolver
ensp
ENSRNOP00065034821
resolver
ensp
ENSRNOP00065034831
resolver
ensp
ENSRNOP00065034836
resolver
ensp
ENSRNOP00065034840
resolver
enst
ENSRNOT00000010510
resolver
enst
ENSRNOT00000095049
resolver
enst
ENSRNOT00000095051
resolver
enst
ENSRNOT00000098205
resolver
enst
ENSRNOT00000113200
resolver
enst
ENSRNOT00000114058
resolver
enst
ENSRNOT00000121918
resolver
enst
ENSRNOT00000123909
resolver
enst
ENSRNOT00000135051
resolver
enst
ENSRNOT00000165121
resolver
enst
ENSRNOT00055028467
resolver
enst
ENSRNOT00055028471
resolver
enst
ENSRNOT00055028474
resolver
enst
ENSRNOT00055028481
resolver
enst
ENSRNOT00055028482
resolver
enst
ENSRNOT00055028487
resolver
enst
ENSRNOT00060004762
resolver
enst
ENSRNOT00060004766
resolver
enst
ENSRNOT00060004768
resolver
enst
ENSRNOT00060004770
resolver
enst
ENSRNOT00060004772
resolver
enst
ENSRNOT00060004773
resolver
enst
ENSRNOT00065042541
resolver
enst
ENSRNOT00065042546
resolver
enst
ENSRNOT00065042556
resolver
enst
ENSRNOT00065042568
resolver
enst
ENSRNOT00065042574
resolver
enst
ENSRNOT00065042577
resolver
genesymbol
Chst1
resolver
uniprot_entry
CHST1_RAT
resolver
amino_acid_sequence
MQCSWKAVLLLALASIAIQYTAIRTFTAKSFHTCPGLTETGLAERLCEEGPTFSYNLSRKTHVLILATTRSGSSFVGQLFNQHMDVFYLFEPLYHVQNTLIPRFTQGKSPADRRVMLGASRDLLRSLYDCDLYFLENYIKPPPVNHTTDRVFRRGASRVLCSRPVCDPPGASDLILEEGDCVRKCGLLNLTLAAEACRERSHVAIKTVRVPEVNDLRALVEDPRLNLKVIQLVRDPRGILASRSETFRDTYRLWRLWYGTGRKPYNLDVTQLTTVCEDFSSSVSTGLMRPSWLKGKYMLVRYEDLARNPMKKTEEIYEFLGIPLDSHVARWIQNNTRGDPTLGKHKYGTVRNSAATAEKWRFRLSYDIVAFAQNACQHVLAQLGYKMATSEEELKNPAISLVEERDFRPFL
uniprot
proteins
ec_number
2.8.2.21
uniprot
proteins
function
FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of internal galactose (Gal) residues of keratan. Cooperates with B4GALT4 and B3GNT7 glycosyltransferases and CHST6 sulfotransferase to construct and elongate disulfated disaccharide unit [->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer. Has a preference for sulfating keratan sulfate, but it also transfers sulfate to the unsulfated polymer (By similarity). Involved in biosynthesis of phosphacan, a major keratan sulfate proteoglycan in the developing brain (By similarity). Involved in biosynthesis of 6-sulfoGalbeta-containing O-linked glycans in high endothelial venules of lymph nodes. May act in a synergistic manner with CHST4 to generate sialyl 6',6-disulfo Lewis X motif, a recognition determinant for immune cell receptors implicated in leukocyte trafficking (By similarity). Catalyzes sulfation of N-acetyllactosamine (LacNAc) oligosaccharides with highest efficiency for sialylated LacNAc structures (By similarity). {ECO:0000250|UniProtKB:O43916, ECO:0000250|UniProtKB:Q9EQC0}.
uniprot
proteins
mass_dalton
46885
uniprot
proteins
pathway_participation
PATHWAY: Glycan metabolism. {ECO:0000250|UniProtKB:O43916}.
uniprot
proteins
protein_family
Gal/GlcNAc/GalNAc subfamily
uniprot
proteins
protein_family
Sulfotransferase 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
411
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 2..23; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins