Tpmt
entrez
690050
canonical
uniprot
Q9Z0T0
canonical
ensembl
ENSRNOG00000016468
resolver
ensp
ENSRNOP00000022084
resolver
genesymbol
Tpmt
resolver
uniprot
B0BMT6
resolver
uniprot_entry
B0BMT6_RAT
resolver
uniprot_entry
TPMT_RAT
resolver
amino_acid_sequence
MSLGIKEHPDAEVQKNRVLTLDDWQDKWVTRHIAFHQEQGHQLLKKHFDTFLKGQSGLRVFFPLCGKAIEMKWFADRGHTVVGVEISEIGIREFFAEQNLSYTEEPLTEIAGAKVFKSSSGNISLYCCSIFDLPRANIGKFDRIWDRGALVAVNPGDRDRYADIILSLLRKGYHYLLVVLSYDPTKHTGPPFYVPDAELKKLFGTKCNMQCLEEVDALEERHKTWGVDYFFEKLYLLTEK
uniprot
proteins
ec_number
2.1.1.67
uniprot
proteins
function
FUNCTION: Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) using S-adenosyl-L-methionine as the methyl donor. TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified. {ECO:0000250|UniProtKB:O55060}.
uniprot
proteins
mass_dalton
27692
uniprot
proteins
protein_family
Class I-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
TPMT family
uniprot
proteins
sequence_length
240
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm.
uniprot
proteins