CTDSPL
entrez
10217
canonical
uniprot
O15194
canonical
ensembl
ENSG00000144677
resolver
ensp
ENSP00000273179
resolver
ensp
ENSP00000398288
resolver
ensp
ENSP00000409600
resolver
enst
ENST00000436654
resolver
genesymbol
CTDSPL
resolver
genesymbol_syn
C3orf8
resolver
genesymbol_syn
NIF1
resolver
genesymbol_syn
NIFL
resolver
genesymbol_syn
SCP3
resolver
genesymbol_syn
YA22
resolver
hgnc
HGNC:16890
resolver
uniprot
H7C353
resolver
uniprot
Q3ZTU0
resolver
uniprot
Q70KI4
resolver
uniprot
Q7Z5Q2
resolver
uniprot_entry
CTDSL_HUMAN
resolver
uniprot_entry
H7C353_HUMAN
resolver
uniprot_sec
Q3ZTU0
resolver
uniprot_sec
Q70KI4
resolver
uniprot_sec
Q7Z5Q2
resolver
amino_acid_sequence
MDGPAIITQVTNPKEDEGRLPGAGEKASQCNVSLKKQRSRSILSSFFCCFRDYNVEAPPPSSPSVLPPLVEENGGLQKGDQRQVIPIPSPPAKYLLPEVTVLDYGKKCVVIDLDETLVHSSFKPISNADFIVPVEIDGTIHQVYVLKRPHVDEFLQRMGQLFECVLFTASLAKYADPVADLLDRWGVFRARLFRESCVFHRGNYVKDLSRLGRELSKVIIVDNSPASYIFHPENAVPVQSWFDDMTDTELLDLIPFFEGLSREDDVYSMLHRLCNR
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. {ECO:0000250, ECO:0000269|PubMed:12721286}.
uniprot
proteins
mass_dalton
31129
uniprot
proteins
pubmed
12721286
uniprot
proteins
pubmed
15051889
uniprot
proteins
pubmed
15681389
uniprot
proteins
pubmed
16533400
uniprot
proteins
pubmed
18058037
uniprot
proteins
pubmed
9179494
uniprot
proteins
sequence_length
276
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins