SEPT9
entrez
10801
canonical
uniprot
Q9UHD8
canonical
ensembl
ENSG00000184640
resolver
ensp
ENSP00000329161
resolver
ensp
ENSP00000391249
resolver
ensp
ENSP00000400181
resolver
ensp
ENSP00000403194
resolver
ensp
ENSP00000405877
resolver
ensp
ENSP00000438089
resolver
ensp
ENSP00000466247
resolver
ensp
ENSP00000466648
resolver
ensp
ENSP00000468120
resolver
ensp
ENSP00000468406
resolver
ensp
ENSP00000504196
resolver
genesymbol
SEPT9
resolver
genesymbol
SEPTIN9
resolver
genesymbol_syn
KIAA0991
resolver
genesymbol_syn
MSF
resolver
genesymbol_syn
SEPT9
resolver
hgnc
HGNC:7323
resolver
uniprot
A0A0S2Z5A5
resolver
uniprot
A8K2V3
resolver
uniprot
B3KPM0
resolver
uniprot
B4DTL9
resolver
uniprot
B4E0N2
resolver
uniprot
B4E274
resolver
uniprot
B7Z654
resolver
uniprot
Q96QF3
resolver
uniprot
Q96QF4
resolver
uniprot
Q96QF5
resolver
uniprot
Q9HA04
resolver
uniprot
Q9UG40
resolver
uniprot
Q9Y5W4
resolver
uniprot_entry
A0A0S2Z5A5_HUMAN
resolver
uniprot_entry
SEPT9_HUMAN
resolver
uniprot_sec
A8K2V3
resolver
uniprot_sec
B3KPM0
resolver
uniprot_sec
B4DTL9
resolver
uniprot_sec
B4E0N2
resolver
uniprot_sec
B4E274
resolver
uniprot_sec
B7Z654
resolver
uniprot_sec
Q96QF3
resolver
uniprot_sec
Q96QF4
resolver
uniprot_sec
Q96QF5
resolver
uniprot_sec
Q9HA04
resolver
uniprot_sec
Q9UG40
resolver
uniprot_sec
Q9Y5W4
resolver
amino_acid_sequence
MKKSYSGGTRTSSGRLRRLGDSSGPALKRSFEVEEVETPNSTPPRRVQTPLLRATVASSTQKFQDLGVKNSEPSARHVDSLSQRSPKASLRRVELSGPKAAEPVSRRTELSIDISSKQVENAGAIGPSRFGLKRAEVLGHKTPEPAPRRTEITIVKPQESAHRRMEPPASKVPEVPTAPATDAAPKRVEIQMPKPAEAPTAPSPAQTLENSEPAPVSQLQSRLEPKPQPPVAEATPRSQEATEAAPSCVGDMADTPRDAGLKQAPASRNEKAPVDFGYVGIDSILEQMRRKAMKQGFEFNIMVVGQSGLGKSTLINTLFKSKISRKSVQPTSEERIPKTIEIKSITHDIEEKGVRMKLTVIDTPGFGDHINNENCWQPIMKFINDQYEKYLQEEVNINRKKRIPDTRVHCCLYFIPATGHSLRPLDIEFMKRLSKVVNIVPVIAKADTLTLEERVHFKQRITADLLSNGIDVYPQKEFDEDSEDRLVNEKFREMIPFAVVGSDHEYQVNGKRILGRKTKWGTIEVENTTHCEFAYLRDLLIRTHMQNIKDITSSIHFEAYRVKRLNEGSSAMANGMEEKEPEAPEM
uniprot
proteins
disease_involvement
DISEASE: Note=A chromosomal aberration involving SEPTIN9/MSF is found in therapy-related acute myeloid leukemia (t-AML). Translocation t(11;17)(q23;q25) with KMT2A/MLL1. {ECO:0000269|PubMed:10339604}.; DISEASE: Hereditary neuralgic amyotrophy (HNA) [MIM:162100]: Autosomal dominant form of recurrent focal neuropathy characterized clinically by acute, recurrent episodes of brachial plexus neuropathy with muscle weakness and atrophy preceded by severe pain in the affected arm. HNA is triggered by environmental factors such as infection or parturition. {ECO:0000269|PubMed:16186812, ECO:0000269|PubMed:17546647, ECO:0000269|PubMed:18492087, ECO:0000269|PubMed:19451530}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. {ECO:0000250, ECO:0000305}.
uniprot
proteins
mass_dalton
65401
uniprot
proteins
protein_family
Septin GTPase family
uniprot
proteins
protein_family
TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily
uniprot
proteins
pubmed
10231032
uniprot
proteins
pubmed
10339604
uniprot
proteins
pubmed
10673329
uniprot
proteins
pubmed
10987277
uniprot
proteins
pubmed
11593400
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15485874
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15558029
uniprot
proteins
pubmed
15915442
uniprot
proteins
pubmed
16007136
uniprot
proteins
pubmed
16186812
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17546647
uniprot
proteins
pubmed
17922164
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18492087
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19145258
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19451530
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
586
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17546647, ECO:0000269|PubMed:17922164}. Note=In an epithelial cell line, concentrates at cell-cell contact areas. After TGF-beta1 treatment and induction of epithelial to mesenchymal transition, colocalizes partly with actin stress fibers. During bacterial infection, displays a collar shape structure next to actin at the pole of invading bacteria.
uniprot
proteins