Slc35b1
entrez
110172
canonical
uniprot
P97858
canonical
ensembl
ENSMUSG00000020873
resolver
ensp
ENSMUSP00000021243
resolver
ensp
ENSMUSP00000166945
resolver
genesymbol
Slc35b1
resolver
genesymbol_syn
Ugalt2
resolver
uniprot
Q8CF70
resolver
uniprot_entry
S35B1_MOUSE
resolver
uniprot_sec
Q8CF70
resolver
amino_acid_sequence
MAASRSLVPDRLRLPLCFLGVFVCYFYYGILQEKITRGKYGEGPKQETFTFALTLVFIQCVINAMFAKILIQFFDTARVDRTRTWLYAACSVSYVGAMVSSNSALQFVNYPTQVLGKSCKPIPVMLLGVTLLKKKYPLAKYLCVLLIVAGVALFMYKPKKVVGIEEHTVGFGELLLLMSLTLDGLTGVSQDHMRAHYQTGSNHMMLNINLWSTFLLGAGILFTGELWEFLSFAERYPTIIYNILLFGLTSALGQSFIFMTVVYFGPLTCSIITTTRKFFTILASVILFANPISSMQWVGTVLVFLGLGLDAKFGKGTKKTSH
uniprot
proteins
function
FUNCTION: ATP:ADP antiporter that catalyzes the exchange of ATP and ADP across the endoplasmic reticulum (ER) membrane (By similarity). Imports ATP from the cytosol to the ER lumen and exports ADP in the opposite direction (By similarity). Regulates ER energy metabolism and protein biogenesis (By similarity). Appears to be part of a calcium-dependent ER to cytosol low energy response axis, where calcium efflux from ER to the cytosol triggers ATP import into the ER lumen to maintain sufficient ATP supply (By similarity). Provides ATP to ER chaperone HSPA5 that drives protein folding and trafficking in the ER (By similarity). Can transport dATP, UTP or UDP in exchange for ATP, but the physiological relevance of this process remains to be established (By similarity). {ECO:0000250|UniProtKB:P78383}.
uniprot
proteins
mass_dalton
35883
uniprot
proteins
protein_family
Nucleotide-sugar transporter family
uniprot
proteins
protein_family
SLC35B subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9010752
uniprot
proteins
sequence_length
322
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P78383}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P78383}.
uniprot
proteins
transmembrane_region
TRANSMEM 12..32; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P78383"; TRANSMEM 51..71; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P78383"; TRANSMEM 85..105; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P78383"; TRANSMEM 109..131; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P78383"; TRANSMEM 138..156; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P78383"; TRANSMEM 174..189; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P78383"; TRANSMEM 205..222; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P78383"; TRANSMEM 239..259; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:P78383"; TRANSMEM 267..287; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:P78383"; TRANSMEM 294..313; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:P78383
uniprot
proteins