SEPTIN7
entrez
989
canonical
uniprot
Q16181
canonical
ensembl
ENSG00000122545
resolver
ensp
ENSP00000344868
resolver
ensp
ENSP00000381992
resolver
ensp
ENSP00000381993
resolver
ensp
ENSP00000413507
resolver
ensp
ENSP00000516132
resolver
enst
ENST00000399034
resolver
enst
ENST00000435235
resolver
genesymbol
SEPTIN7
resolver
genesymbol_syn
CDC10
resolver
genesymbol_syn
SEPT7
resolver
hgnc
HGNC:1717
resolver
uniprot
A0A023T695
resolver
uniprot
A0A024RA47
resolver
uniprot
A0A024RA87
resolver
uniprot
A8K3D0
resolver
uniprot
B4DNE4
resolver
uniprot
G3V1Q4
resolver
uniprot
Q52M76
resolver
uniprot
Q6NX50
resolver
uniprot_entry
A0A023T695_HUMAN
resolver
uniprot_entry
A0A024RA87_HUMAN
resolver
uniprot_entry
A8K3D0_HUMAN
resolver
uniprot_entry
B4DNE4_HUMAN
resolver
uniprot_entry
G3V1Q4_HUMAN
resolver
uniprot_entry
SEPT7_HUMAN
resolver
uniprot_sec
A0A024RA47
resolver
uniprot_sec
Q52M76
resolver
uniprot_sec
Q6NX50
resolver
amino_acid_sequence
MSVSARSAAAEERSVNSSTMVAQQKNLEGYVGFANLPNQVYRKSVKRGFEFTLMVVGESGLGKSTLINSLFLTDLYSPEYPGPSHRIKKTVQVEQSKVLIKEGGVQLLLTIVDTPGFGDAVDNSNCWQPVIDYIDSKFEDYLNAESRVNRRQMPDNRVQCCLYFIAPSGHGLKPLDIEFMKRLHEKVNIIPLIAKADTLTPEECQQFKKQIMKEIQEHKIKIYEFPETDDEEENKLVKKIKDRLPLAVVGSNTIIEVNGKRVRGRQYPWGVAEVENGEHCDFTILRNMLIRTHMQDLKDVTNNVHYENYRSRKLAAVTYNGVDNNKNKGQLTKSPLAQMEEERREHVAKMKKMEMEMEQVFEMKVKEKVQKLKDSEAELQRRHEQMKKNLEAQHKELEEKRRQFEDEKANWEAQQRILEQQNSSRTLEKNKKKGKIF
uniprot
proteins
function
FUNCTION: Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (PubMed:25588830). {ECO:0000269|PubMed:17803907, ECO:0000269|PubMed:18460473, ECO:0000305|PubMed:25588830}.
uniprot
proteins
mass_dalton
50680
uniprot
proteins
protein_family
Septin GTPase family
uniprot
proteins
protein_family
TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily
uniprot
proteins
pubmed
15485874
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15592455
uniprot
proteins
pubmed
15915442
uniprot
proteins
pubmed
16093351
uniprot
proteins
pubmed
16914550
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17637674
uniprot
proteins
pubmed
17803907
uniprot
proteins
pubmed
18460473
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19145258
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25588830
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28346465
uniprot
proteins
pubmed
8037772
uniprot
proteins
sequence_length
437
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18460473}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:18460473}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:18460473}. Cleavage furrow {ECO:0000269|PubMed:18460473}. Midbody {ECO:0000269|PubMed:18460473}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250}. Cell projection, cilium, flagellum {ECO:0000269|PubMed:25588830}. Note=Distributed throughout the cytoplasm in prometaphase cells. Associated with the spindle during metaphase. Associated with the central spindle and at the cleavage furrow in anaphase cells. Detected at the midbody in telophase. Associated with actin stress fibers (By similarity). Found in the sperm annulus (PubMed:25588830). {ECO:0000250, ECO:0000269|PubMed:25588830}.
uniprot
proteins