Nav2
entrez
78286
canonical
uniprot
V9GX91
canonical
ensembl
ENSMUSG00000052512
resolver
ensp
ENSMUSP00000139045
resolver
ensp
ENSMUSP00000139309
resolver
enst
ENSMUST00000183659
resolver
genesymbol
Nav2
resolver
genesymbol_syn
mKIAA3015
resolver
uniprot
Q6ZPE7
resolver
uniprot
Q8BJG0
resolver
uniprot
Q8BYE8
resolver
uniprot
Q8BYJ2
resolver
uniprot
V9GXT3
resolver
uniprot_entry
NAV2_MOUSE
resolver
uniprot_entry
Q6ZPE7_MOUSE
resolver
uniprot_entry
Q8BJG0_MOUSE
resolver
uniprot_entry
Q8BYE8_MOUSE
resolver
uniprot_entry
Q8BYJ2_MOUSE
resolver
uniprot_entry
V9GXT3_MOUSE
resolver
amino_acid_sequence
MPAILVASKMKSGLPKPVHSAAPILHVPPARTGPQPCYLKLGSKVEVSKTAYTSQIPLKSQGLQEPTGEGLPLLKSSSLENGFDTQIYTDWANHYLAKSGHKRLIKDLQQDVTDGVLLAQIIQVVANDKIEDINGCPKNRSQMIENIDACLNFLAAKGINTQGLSAEEIRNGNLKAILGLFFSLSRYKQQQQQQQQQPEKQPLSSSPLPPAGSQVAGAPSQCQAGTPQHQGLATPQAPCQLLQPVSHQQGKTQVEMQSRLPGPTARVAAAGSEAKTRGGSAAANNRRSQSFNNYDKSKPVTSPPPPAPPSNHEKEPLASSASSHPGMSENVPAPLENSPSVPVNCSSSAIPQPSMTSKPWRSKSLSVKHTATSAMLSVKPAGPEAPRPTPEAMKPAPNNQKSMLEKLKLFNSKGGSKAGEGSASRDTSCERLEILPSFEETEELEATANRALSTVGPASSSPKIALKGIAQRTFSRALTNKKSSPKGNEKEKEKQQREKEKEKEKEKGKDLTKRVSVTDRPDLKEETKADLSGVAVTEMPKKSSKIASFIPKGGKLNSTKKEATAPSHSGIPKPGMKNVSAKSPSAPIPPKEGERSRGKLSSGLPPQKAQLDSRHSSSSSSLASSEGKGPGGTSLNPSISSQTVSGSVGTTQTTGSNTVSVQLPQPQQQYNHPNTATVAPFLYRSQTDTEGNVTAESSSAGVSMEPSHYTKSGQPALEELTEDPEARRLRTVKNIADLRQNLEETMSSLRGTQVTHSTLETTFDTNVTTEISGRSILSLTGRPTPLSWRLGQSSPRLQAGDAPSMGNGYPPRANASRFISAEAGRYVYSAPLRRQLASRGSSICHVDVSDKADDDVDLEGISMDAPGYMSDGDVLSKNIRSDDITSGYMTDGGLGLYTRRLNRLPDGMAVVRETLQRNTSLGLGDADSWDDSSSVSSGISDTIDNLSTDDINTSSSISSYANTPASSRRNLDVQTDAEKHSQVERNSLWSGDDIKKSDGGSDSGVKMEPGSKWRRNPSDMSDESDKSVSGKKNPVLSQTGSWRRGMTAEVGITMPRTKPSAPTGTLKTPGTGKTDDAKVSEKGRLSPKASQVKRSPSDAGRSSGDESKKTLPSSSRTPTVNANSFGFKKQSGSAAGLAMITASGATVTSRSATLGKIPKSSALVGRPTGRKTSMDGAPNQDDGYLSLSSRTNLQYRSLPRPSKSNSRNGAGNRCSTSSIDSNMSSKSAGLPVPKLREPSKASLGSSLPGLVNQTDKEKGISSDSESVASCNSVKVNPATQPVSSSAQATLQPGTKYADVASPTLRRLFGGKPTKPIATAETMKSAVVISNPHATLTQQGNLESPSGSGVLSSGSSSPLYSKNVDLNQSPLASSPSSAHSGPSNSLTWGTSSSAVSKDGLGFQSVSSLHTSCESIDISLGSGGGLSHNSSPGPVASTKEDSLMPFVRTSSVKTTLSESPLSSPAASPKFCRSTLPRKQDSDPHLDRNTLPKKGLRYTPTSQLRTQEDAKEWFRSHSAGGLQDTATNSPFSSGSSVTSPSGTRFNFSQLASPTAVTQMSLSNPTMLRTHSLSNADGQYDPYTDSRFRNSSMSLDEKSRTMSRSGSFRDGFEEVHGSSLSLVSSTSSIYSTPEEKCQSEIRKLRRELDASQEKVSALTTQLTANAHLVAAFEQSLGNMTIRLQSLTMTAEQKDSELNELRKTIELLKKQNAAAQAAINGVINTPELNCKGNGSAQATDLRIRRQHSSDSVSSINSATSHSSVGSNIESDSKKKKRKNWVNELRSSFKQAFGKKKSPKSASSHSDIEEMTDSSLPSSPKLPHNGSTGSTPLLRNAHSNSLISECMDSEAETVMQLRNELRDKEMKLTDIRLEALSSAHQLDQLREAMNRMQSEIEKLKAENDRLKSESQGSGCSRAPSQVSISASPRQSLGLSQHSLNLTESTSLDMLLDDTGECSARKEGGRHVKIVVSFQEAMKWKEDSRPHLFLIGCIGVSGKTKWDVLDGVVRRLFKEYIVHVDPVSQLGLSSDSVLGYSIGEIKRSNASETPELLPCGYLVGENTTILVTVKGLTENSLDSLVFESLIPKPILQRYVSLLTEHRRIILSGPSGTGKTYLANRLSEYVVLREGRELTDGVIATFNVDHKSSKELRQYLSNLADQCNSENNAVDMPLVIILDNLHHVSSLGEIFNGLLNCKYHKCPYIIGTMNQATSSTPNLQLHHNFRWVLCANHTEPVKGFLGRFLRRKLMETEISGRVRNAELVKIINWIPKVWHHLNRFLEAHSSSDVTIGPRLFLSCPIDVDGSRVWFTDLWNYSIIPYLLEAVREGLQLYGRRAPWEDPAKWVMDTYPWAASPQQHEWPPLLQLRPEDVGFDGYSLPREGSTSKQVPPSDTEGDPLMNMLMRLQEAANYSSPQSYDSDSNSNSHHDDILDSSLESTL
uniprot
proteins
ec_number
3.6.4.12
uniprot
proteins
function
FUNCTION: Possesses 3' to 5' helicase activity and exonuclease activity (By similarity). Involved in cytoskeleton organization (By similarity). Required for neurite outgrowth in response to stimulation by all-trans retinoic acid (atRA) (By similarity). Involved in neuronal development, specifically in the development of different sensory organs (PubMed:35218524). Important for brain and cerebellar development (PubMed:21419114, PubMed:32081718, PubMed:35218524). Involved in the differentiation, migration and axonal extension of granule cells in the developing cerebellum (PubMed:21419114). Involved in the development of the glossopharyngeal cranial nerve IX and the vagus cranial nerve X, possibly by influencing neuronal cell elongation or survival; influencing the efficiency of the baroreceptor reflex response to changes in blood pressure (PubMed:20184720). {ECO:0000250|UniProtKB:Q8IVL1, ECO:0000269|PubMed:20184720, ECO:0000269|PubMed:21419114, ECO:0000269|PubMed:32081718, ECO:0000269|PubMed:35218524}.
uniprot
proteins
mass_dalton
261662
uniprot
proteins
protein_family
Nav/unc-53 family
uniprot
proteins
pubmed
15158073
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20184720
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21419114
uniprot
proteins
pubmed
32081718
uniprot
proteins
pubmed
35218524
uniprot
proteins
sequence_length
2432
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8IVL1}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q8IVL1}. Cell projection, axon {ECO:0000250|UniProtKB:Q8IVL1}. Perikaryon {ECO:0000250|UniProtKB:Q8IVL1}. Note=Colocalizes with neurofilaments in the perikaryon and the neurites/axons of neuronal cells. Partially colocalizes in a punctate fashion along the length of microtubules. {ECO:0000250|UniProtKB:Q8IVL1}.
uniprot
proteins