CYTH2
entrez
9266
canonical
uniprot
Q99418
canonical
ensembl
ENSG00000105443
resolver
ensp
ENSP00000408236
resolver
ensp
ENSP00000493357
resolver
genesymbol
CYTH2
resolver
genesymbol_syn
ARNO
resolver
genesymbol_syn
PSCD2
resolver
genesymbol_syn
PSCD2L
resolver
hgnc
HGNC:9502
resolver
uniprot
A8K8P0
resolver
uniprot
Q8IXY9
resolver
uniprot
Q92958
resolver
uniprot_entry
CYH2_HUMAN
resolver
uniprot_sec
A8K8P0
resolver
uniprot_sec
Q8IXY9
resolver
uniprot_sec
Q92958
resolver
amino_acid_sequence
MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP
uniprot
proteins
function
FUNCTION: Acts as a guanine-nucleotide exchange factor (GEF). Promotes guanine-nucleotide exchange on ARF1, ARF3 and ARF6. Activates ARF factors through replacement of GDP with GTP (By similarity). The cell membrane form, in association with ARL4 proteins, recruits ARF6 to the plasma membrane (PubMed:17398095). Involved in neurite growth (By similarity). {ECO:0000250|UniProtKB:P63034, ECO:0000269|PubMed:17398095}.
uniprot
proteins
mass_dalton
46546
uniprot
proteins
mutagenesis
MUTAGEN 156; /note="E->D: Inhibits GTPGDP exchange activity. Abolishes recruitment of ARF6 to the plasma membrane."; /evidence="ECO:0000269|PubMed:17398095"; MUTAGEN 268; /note="K->R: Does not reduce ARL4DGTP-dependent interaction but inhibits targeting to the plasma membrane mediated by ARL4C, ARL4C and ARL4D."; /evidence="ECO:0000269|PubMed:17398095"; MUTAGEN 280; /note="R->D: Does not reduce ARL4DGTP-dependent interaction but inhibits targeting to the plasma membrane mediated by ARL4C, ARL4C and ARL4D."; /evidence="ECO:0000269|PubMed:17398095"; MUTAGEN 303; /note="I->A: Reduces ARL4DGTP-dependent interaction and targeting to the plasma membrane mediated by ARL4C, ARL4C and ARL4D."; /evidence="ECO:0000269|PubMed:17398095"; MUTAGEN 336; /note="K->A: Reduces ARL4DGTP-dependent interaction and targeting to the plasma membrane mediated by ARL4C, ARL4C and ARL4D."; /evidence="ECO:0000269|PubMed:17398095
uniprot
proteins
pubmed
14654833
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17398095
uniprot
proteins
pubmed
17623778
uniprot
proteins
pubmed
25326380
uniprot
proteins
pubmed
29420262
uniprot
proteins
pubmed
8945478
uniprot
proteins
pubmed
9417041
uniprot
proteins
pubmed
9476900
uniprot
proteins
pubmed
9510256
uniprot
proteins
sequence_length
400
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17398095}; Peripheral membrane protein {ECO:0000269|PubMed:17398095}. Cytoplasm {ECO:0000269|PubMed:17398095}. Cell projection {ECO:0000250|UniProtKB:P63034}. Cell projection, growth cone {ECO:0000250|UniProtKB:P63034}. Cell junction, tight junction {ECO:0000250|UniProtKB:P63034}. Cell junction, adherens junction {ECO:0000250|UniProtKB:P63034}. Note=Both isoform 1 and isoform 2 are recruited to the cell membrane through its association with ARL4A, ARL4C and ARL4D. They require also interaction with phosphoinositides for targeting to plasma membrane (PubMed:17398095). In differentiating neuroblastoma cells, colocalizes with CCDC120 in both neurite shaft and growth cone areas. {ECO:0000250|UniProtKB:P63034, ECO:0000269|PubMed:17398095}.
uniprot
proteins