Mdm4
entrez
304798
canonical
uniprot
Q5XIN1
canonical
ensembl
ENSRNOG00000009696
resolver
ensp
ENSRNOP00000012984
resolver
ensp
ENSRNOP00000076729
resolver
ensp
ENSRNOP00000084671
resolver
enst
ENSRNOT00000012984
resolver
enst
ENSRNOT00000112527
resolver
genesymbol
Mdm4
resolver
genesymbol_syn
Mdmx
resolver
uniprot
A0A8I6A2G0
resolver
uniprot
A0A8L2Q5T6
resolver
uniprot_entry
A0A8I6A2G0_RAT
resolver
uniprot_entry
A0A8L2Q5T6_RAT
resolver
uniprot_entry
MDM4_RAT
resolver
amino_acid_sequence
MTSHSTSAQCSASDSACRISSEQINQQVRPKLQLLKILQAAGAQGEVFTMKEVMHYLGQYIMVKQLYDQQEQHLVYCGGDLLGDLLGCQSFSVKDPSPLYDMLRKNLVTSASVNTDAAQTLALAQDHTMDIPSQDRLKHGATECSNPRKRTEEDDTHTLPTSRRKCRDSRADEDLIEHLSQDETSRLDLDFEEWDVAGLPWWFLGNLRNNYIPRSNGSTDLQTNQDIGTAIVSDTTDDLWFLNETVSEQLGVGVKVEAANCEQPSEVGRTRDKKMVEGGKDDDLEDSKSLSDDTDVEVTSEDEWQCTECKKFNSPSKRYCFRCWALRKDWYSDCSKLTHSLSTSNITAIPEKKDNEGIDVPDCRRTISAPVVRPKDGYLKEEKPRFDPCNSVEFLDLAHGSESQEIISSTREQTDIFSEQKTETESMEDFQNVLKPCSLCEKRPRDGNIIHGKTSHLTTCFHCARRLKKSGASCPACKKEIQLVIKVFIA
uniprot
proteins
function
FUNCTION: Contributes to p53/TP53 regulation. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding their transcriptional activation domains. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions (By similarity). {ECO:0000250|UniProtKB:O15151}.
uniprot
proteins
mass_dalton
55221
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation at Ser-368 promotes interaction with YWHAG and subsequent ubiquitination and degradation. Phosphorylation at Ser-342 also induces ubiquitination and degradation but to a lower extent (By similarity). {ECO:0000250|UniProtKB:O15151}.; PTM: Ubiquitinated and degraded by MDM2. Deubiquitination by USP2 on the other hand stabilizes the MDM4 protein (By similarity). {ECO:0000250|UniProtKB:O15151}.
uniprot
proteins
protein_family
MDM2/MDM4 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
490
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O15151}. Cytoplasm {ECO:0000250|UniProtKB:O15151}.
uniprot
proteins