Ormdl3
entrez
360618
canonical
uniprot
Q6QI25
canonical
ensembl
ENSRNOG00000030445
resolver
ensp
ENSRNOP00000046432
resolver
enst
ENSRNOT00000049621
resolver
genesymbol
Ormdl3
resolver
uniprot_entry
ORML3_RAT
resolver
amino_acid_sequence
MNVGTAHSEVNPNTRVMNSRGIWLSYVLAIGLLHVVLLSIPFVSVPVVWTLTNLIHNLGMYIFLHTVKGTPFETPDQGKARLLTHWEQMDYGVQFTASRKFLTITPIVLYFLTSFYTKYDQVHFILNTVSLMSVLIPKLPQLHGVRIFGINKY
uniprot
proteins
function
FUNCTION: Plays an essential role in the homeostatic regulation of sphingolipid de novo biosynthesis by modulating the activity of the serine palmitoyltransferase (SPT) in response to ceramide levels. When complexed to SPT, the binding of ceramides to its N-terminus stabilizes a conformation that block SPT substrate entry, hence preventing SPT catalytic activity. Through this mechanism, maintains ceramide levels at sufficient concentrations for the production of complex sphingolipids, but which prevents the accumulation of ceramides to levels that trigger apoptosis. {ECO:0000250|UniProtKB:Q8N138}.
uniprot
proteins
mass_dalton
17463
uniprot
proteins
post_translational_modification
PTM: When hydroxylated at Pro-137, ubiquitinated via 'Lys-48'-linkage, leading to proteasomal degradation. In endothelial cells, ORMDL3 proteasomal degradation is controlled by the sphingosine 1-phosphate receptor signaling pathway. {ECO:0000250|UniProtKB:Q8N138}.
uniprot
proteins
protein_family
ORM family
uniprot
proteins
sequence_length
153
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q8N138}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8N138}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q8N138, ECO:0000255"; TRANSMEM 43..63; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q8N138, ECO:0000255"; TRANSMEM 95..117; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q8N138, ECO:0000255"; TRANSMEM 122..142; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q8N138, ECO:0000255
uniprot
proteins