RAB40C
entrez
57799
canonical
uniprot
Q96S21
canonical
ensembl
ENSG00000197562
resolver
ensp
ENSP00000248139
resolver
ensp
ENSP00000438382
resolver
ensp
ENSP00000438492
resolver
ensp
ENSP00000445050
resolver
ensp
ENSP00000455225
resolver
genesymbol
RAB40C
resolver
genesymbol_syn
RARL
resolver
genesymbol_syn
RASL8C
resolver
hgnc
HGNC:18285
resolver
uniprot
A2IDE2
resolver
uniprot
D3DU54
resolver
uniprot
O60795
resolver
uniprot
Q4TT41
resolver
uniprot
Q5PXE8
resolver
uniprot
Q6PIU5
resolver
uniprot_entry
RB40C_HUMAN
resolver
uniprot_sec
A2IDE2
resolver
uniprot_sec
D3DU54
resolver
uniprot_sec
O60795
resolver
uniprot_sec
Q4TT41
resolver
uniprot_sec
Q5PXE8
resolver
uniprot_sec
Q6PIU5
resolver
activity_regulation
ACTIVITY REGULATION: Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP (Probable). Regulated by GTPase activating proteins (GAPs) including DAB2IP, which increase the GTP hydrolysis activity (PubMed:29156729). Inhibited by GDP dissociation inhibitors (GDIs) (Probable). {ECO:0000269|PubMed:29156729, ECO:0000305}.
uniprot
proteins
amino_acid_sequence
MGSQGSPVKSYDYLLKFLLVGDSDVGKGEILESLQDGAAESPYAYSNGIDYKTTTILLDGRRVKLELWDTSGQGRFCTIFRSYSRGAQGILLVYDITNRWSFDGIDRWIKEIDEHAPGVPRILVGNRLHLAFKRQVPTEQARAYAEKNCMTFFEVSPLCNFNVIESFTELSRIVLMRHGMEKIWRPNRVFSLQDLCCRAIVSCTPVHLIDKLPLPVTIKSHLKSFSMANGMNAVMMHGRSYSLASGAGGGGSKGNSLKRSKSIRPPQSPPQNCSRSNCKIS
uniprot
proteins
ec_number
3.6.5.2
uniprot
proteins
function
FUNCTION: RAB40C small GTPase acts as substrate-recognition component of the ECS(RAB40C) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:35512830). The Rab40 subfamily belongs to the Rab family that are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:29156729). As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration (PubMed:35512830). Also negatively regulate lipid droplets accumulation in a GTP-dependent manner (PubMed:29156729). {ECO:0000269|PubMed:15601820, ECO:0000269|PubMed:29156729, ECO:0000269|PubMed:35512830}.
uniprot
proteins
mass_dalton
31304
uniprot
proteins
mutagenesis
MUTAGEN 28; /note="G->N: Constitutively inactive (GDP-bound) mutant. Increased lipid droplets accumulation."; /evidence="ECO:0000269|PubMed:29156729"; MUTAGEN 73; /note="Q->L: Constitutively active (GTP-bound) mutant. Decreased lipid droplets accumulation."; /evidence="ECO:0000269|PubMed:29156729"; MUTAGEN 212..215; /note="LPLP->AAAA: Abolishes interaction with RNF7 and CUL5."; /evidence="ECO:0000269|PubMed:15601820, ECO:0000269|PubMed:35512830"; MUTAGEN 221..222; /note="HL->AA: Abolishes interaction with RNF7."; /evidence="ECO:0000269|PubMed:15601820
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
Rab family
uniprot
proteins
protein_family
Small GTPase superfamily
uniprot
proteins
pubmed
11157797
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15601820
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
29156729
uniprot
proteins
pubmed
35512830
uniprot
proteins
sequence_length
281
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Cytoplasm, cytosol {ECO:0000269|PubMed:35512830}. Golgi apparatus membrane {ECO:0000269|PubMed:35512830}. Note=Mostly localized in the cytosol and also with actin ruffles. {ECO:0000269|PubMed:35512830}.
uniprot
proteins