AXIN2
entrez
8313
canonical
uniprot
Q9Y2T1
canonical
ensembl
ENSG00000168646
resolver
ensp
ENSP00000302625
resolver
ensp
ENSP00000364854
resolver
ensp
ENSP00000478916
resolver
ensp
ENSP00000551090
resolver
ensp
ENSP00000551091
resolver
ensp
ENSP00000551092
resolver
ensp
ENSP00000551093
resolver
ensp
ENSP00000551094
resolver
enst
ENST00000307078
resolver
enst
ENST00000375702
resolver
enst
ENST00000618960
resolver
enst
ENST00000881031
resolver
enst
ENST00000881032
resolver
enst
ENST00000881033
resolver
enst
ENST00000881034
resolver
enst
ENST00000881035
resolver
genesymbol
AXIN2
resolver
hgnc
HGNC:904
resolver
uniprot
B7ZKL5
resolver
uniprot
E7ES00
resolver
uniprot
Q3MJ88
resolver
uniprot
Q9H3M6
resolver
uniprot
Q9UH84
resolver
uniprot_entry
AXIN2_HUMAN
resolver
uniprot_entry
B7ZKL5_HUMAN
resolver
uniprot_entry
E7ES00_HUMAN
resolver
uniprot_sec
Q3MJ88
resolver
uniprot_sec
Q9H3M6
resolver
uniprot_sec
Q9UH84
resolver
amino_acid_sequence
MSSAMLVTCLPDPSSSFREDAPRPPVPGEEGETPPCQPGVGKGQVTKPMPVSSNTRRNEDGLGEPEGRASPDSPLTRWTKSLHSLLGDQDGAYLFRTFLEREKCVDTLDFWFACNGFRQMNLKDTKTLRVAKAIYKRYIENNSIVSKQLKPATKTYIRDGIKKQQIDSIMFDQAQTEIQSVMEENAYQMFLTSDIYLEYVRSGGENTAYMSNGGLGSLKVVCGYLPTLNEEEEWTCADFKCKLSPTVVGLSSKTLRATASVRSTETVDSGYRSFKRSDPVNPYHIGSGYVFAPATSANDSEISSDALTDDSMSMTDSSVDGIPPYRVGSKKQLQREMHRSVKANGQVSLPHFPRTHRLPKEMTPVEPATFAAELISRLEKLKLELESRHSLEERLQQIREDEEREGSELTLNSREGAPTQHPLSLLPSGSYEEDPQTILDDHLSRVLKTPGCQSPGVGRYSPRSRSPDHHHHHHSQYHSLLPPGGKLPPAAASPGACPLLGGKGFVTKQTTKHVHHHYIHHHAVPKTKEEIEAEATQRVHCFCPGGSEYYCYSKCKSHSKAPETMPSEQFGGSRGSTLPKRNGKGTEPGLALPAREGGAPGGAGALQLPREEGDRSQDVWQWMLESERQSKPKPHSAQSTKKAYPLESARSSPGERASRHHLWGGNSGHPRTTPRAHLFTQDPAMPPLTPPNTLAQLEEACRRLAEVSKPPKQRCCVASQQRDRNHSATVQTGATPFSNPSLAPEDHKEPKKLAGVHALQASELVVTYFFCGEEIPYRRMLKAQSLTLGHFKEQLSKKGNYRYYFKKASDEFACGAVFEEIWEDETVLPMYEGRILGKVERID
uniprot
proteins
disease_involvement
DISEASE: Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. {ECO:0000269|PubMed:11017067}. Note=The gene represented in this entry is involved in disease pathogenesis.; DISEASE: Oligodontia-colorectal cancer syndrome (ODCRCS) [MIM:608615]: Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types. {ECO:0000269|PubMed:15042511}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B. {ECO:0000250|UniProtKB:O15169}.
uniprot
proteins
mass_dalton
93568
uniprot
proteins
post_translational_modification
PTM: Probably phosphorylated by GSK3B and dephosphorylated by PP2A. {ECO:0000250|UniProtKB:O15169}.; PTM: ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway. {ECO:0000269|PubMed:21383061}.; PTM: Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription. {ECO:0000269|PubMed:21383061}.
uniprot
proteins
pubmed
10049590
uniprot
proteins
pubmed
11017067
uniprot
proteins
pubmed
15042511
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16601693
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
16820935
uniprot
proteins
pubmed
19759537
uniprot
proteins
pubmed
21383061
uniprot
proteins
pubmed
21478859
uniprot
proteins
pubmed
28546513
uniprot
proteins
sequence_length
843
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21383061}.
uniprot
proteins