TSKU
entrez
25987
canonical
uniprot
Q8WUA8
canonical
ensembl
ENSG00000182704
resolver
ensp
ENSP00000332668
resolver
ensp
ENSP00000434847
resolver
ensp
ENSP00000482145
resolver
ensp
ENSP00000540351
resolver
ensp
ENSP00000540352
resolver
ensp
ENSP00000540353
resolver
ensp
ENSP00000540354
resolver
ensp
ENSP00000540355
resolver
ensp
ENSP00000540356
resolver
ensp
ENSP00000540357
resolver
ensp
ENSP00000540358
resolver
ensp
ENSP00000540359
resolver
ensp
ENSP00000626964
resolver
ensp
ENSP00000626965
resolver
enst
ENST00000333090
resolver
enst
ENST00000527881
resolver
enst
ENST00000612930
resolver
enst
ENST00000870292
resolver
enst
ENST00000870293
resolver
enst
ENST00000870294
resolver
enst
ENST00000870295
resolver
enst
ENST00000870296
resolver
enst
ENST00000870297
resolver
enst
ENST00000870298
resolver
enst
ENST00000870299
resolver
enst
ENST00000870300
resolver
enst
ENST00000956905
resolver
enst
ENST00000956906
resolver
genesymbol
TSKU
resolver
genesymbol_syn
E2IG4
resolver
genesymbol_syn
LRRC54
resolver
genesymbol_syn
TSK
resolver
hgnc
HGNC:28850
resolver
uniprot
B3KQT7
resolver
uniprot
B3KRF9
resolver
uniprot
Q6UXK1
resolver
uniprot
Q9UG10
resolver
uniprot
Q9UJX9
resolver
uniprot_entry
B3KRF9_HUMAN
resolver
uniprot_entry
TSK_HUMAN
resolver
uniprot_sec
B3KQT7
resolver
uniprot_sec
Q6UXK1
resolver
uniprot_sec
Q9UG10
resolver
uniprot_sec
Q9UJX9
resolver
amino_acid_sequence
MPWPLLLLLAVSGAQTTRPCFPGCQCEVETFGLFDSFSLTRVDCSGLGPHIMPVPIPLDTAHLDLSSNRLEMVNESVLAGPGYTTLAGLDLSHNLLTSISPTAFSRLRYLESLDLSHNGLTALPAESFTSSPLSDVNLSHNQLREVSVSAFTTHSQGRALHVDLSHNLIHRLVPHPTRAGLPAPTIQSLNLAWNRLHAVPNLRDLPLRYLSLDGNPLAVIGPGAFAGLGGLTHLSLASLQRLPELAPSGFRELPGLQVLDLSGNPKLNWAGAEVFSGLSSLQELDLSGTNLVPLPEALLLHLPALQSVSVGQDVRCRRLVREGTYPRRPGSSPKVALHCVDTRDSAARGPTIL
uniprot
proteins
function
FUNCTION: Contributes to various developmental events and other processes such as wound healing and cholesterol homeostasis through its interactions with multiple signaling pathways. Wnt signaling inhibitor which competes with WNT2B for binding to Wnt receptor FZD4 and represses WNT2B-dependent development of the peripheral eye. Plays a role in regulating the hair cycle by controlling TGFB1 signaling. Required for the development of the anterior commissure in the brain by inhibiting neurite outgrowth. Essential for terminal differentiation of hippocampal neural stem cells. Plays a role in regulating bone elongation and bone mass by modulating growth plate chondrocyte function and overall body size. Required for development of the inner ear through its involvement in stereocilia formation in inner hair cells. Facilitates wound healing by inhibiting secretion of TGFB1 from macrophages which prevents myofibroblast differentiation, maintaining inflammatory cell quiescence. Plays a role in cholesterol homeostasis by reducing circulating high-density lipoprotein cholesterol, lowering cholesterol efflux capacity and decreasing cholesterol-to-bile acid conversion in the liver. In one study, shown to negatively regulate sympathetic innervation in brown fat, leading to reduced energy expenditure. In another study, shown not to affect brown fat thermogenic capacity, body weight gain or glucose homeostasis. {ECO:0000250|UniProtKB:Q8CBR6}.
uniprot
proteins
mass_dalton
37807
uniprot
proteins
pubmed
11085516
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
30232710
uniprot
proteins
sequence_length
353
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q8CBR6}.
uniprot
proteins