Prrt1
entrez
260297
canonical
uniprot
O35449
canonical
ensembl
ENSMUSG00000015476
resolver
ensp
ENSMUSP00000015620
resolver
ensp
ENSMUSP00000243431
resolver
ensp
ENSMUSP00000243434
resolver
enst
ENSMUST00000015620
resolver
genesymbol
Prrt1
resolver
genesymbol_syn
Ng5
resolver
uniprot_entry
PRRT1_MOUSE
resolver
amino_acid_sequence
MSSEKSGLPDSVPHTSPPPYNAPQPPAEPPIPPPQTAPSSHHHHHHHYHQSGTATLPRLGAGGLASAAASAQRGPSSSATLPRPPHHAPPGPAAGAPPPGCATLPRMPPDPYLQETRFEGPLPPPPPAAAAPPPPAPAPTAQAPGFVVPTHAGAVGTLPLGGYVAPGYPLQLQPCTAYVPVYPVGTPYAGGTPGGPGVTSTLPPPPQGPGLALLEPRRPPHDYMPIAVLTTICCFWPTGIIAIFKAVQVRTALARGDLVSAEIASREARNFSFISLAVGIAAMVLCTILTVVIIIAAQHHENYWDP
uniprot
proteins
function
FUNCTION: Required to maintain a pool of extrasynaptic AMPA-regulated glutamate receptors (AMPAR) which is necessary for synapse development and function (PubMed:29490264). Regulates AMPAR function and synaptic transmission during development but is dispensable at mature hippocampal synapses (PubMed:29490264, PubMed:31216424). Plays a role in regulating basal phosphorylation levels of glutamate receptor GRIA1 and promotes GRIA1 and GRIA2 cell surface expression (PubMed:31216424). {ECO:0000269|PubMed:29490264, ECO:0000269|PubMed:31216424}.
uniprot
proteins
mass_dalton
31389
uniprot
proteins
protein_family
CD225/Dispanin family
uniprot
proteins
pubmed
14656967
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22363774
uniprot
proteins
pubmed
22632720
uniprot
proteins
pubmed
29490264
uniprot
proteins
pubmed
31216424
uniprot
proteins
sequence_length
306
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:22632720}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:Q6MG82}. Synapse {ECO:0000305|PubMed:22632720}.
uniprot
proteins
transmembrane_region
TRANSMEM 224..244; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins