Gabra4
entrez
140675
canonical
uniprot
P28471
canonical
ensembl
ENSRNOG00000002336
resolver
ensp
ENSRNOP00000003191
resolver
enst
ENSRNOT00000003191
resolver
genesymbol
Gabra4
resolver
uniprot_entry
GBRA4_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Potentiated by histamine. {ECO:0000250|UniProtKB:P48169}.
uniprot
proteins
amino_acid_sequence
MVSVQKVPAIVLCSGVSLALLHVLCLATCLNESPGQNSKDEKLCPENFTRILDSLLDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIEILRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPMRLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPEKSVEVPKESSSLVQYDLIGQTVSSETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMQKAKKKISKPPPEVPAAPVLKEKHTETSLQNTHANLNMRKRTNALVHSESDVNSRTEVGNHSSKTTAAQESSETTPKAHLASSPNPFSRANAAETISAAARGLSSAASPSPHGTLQPAPLRSASARPAFGARLGRIKTTVNTTGVPGNVSATPPPSAPPPSGSGTSKIDKYARILFPVTFGAFNMVYWVVYLSKDTMEKSESLM
uniprot
proteins
function
FUNCTION: Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (By similarity). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). Alpha-4/GABRA4 subunit often assembles with delta or gamma-2 subunits, in combination with beta subunits (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). GABAARs containing alpha-4 are predominantly extrasynaptic, contributing to tonic inhibition in dentate granule cells and thalamic relay neurons (By similarity). Extrasynaptic alpha-4-containing GABAARs control levels of excitability and network activity (By similarity). GABAAR containing alpha-4-beta-3-delta subunits can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness (By similarity). {ECO:0000250|UniProtKB:P48169, ECO:0000250|UniProtKB:Q9D6F4}.
uniprot
proteins
mass_dalton
60951
uniprot
proteins
protein_family
GABRA4 sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
1655526
uniprot
proteins
pubmed
24090084
uniprot
proteins
sequence_length
552
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9D6F4}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48169}. Postsynaptic cell membrane; Multi-pass membrane protein {ECO:0000250|UniProtKB:P48169}.
uniprot
proteins
transmembrane_region
TRANSMEM 260..280; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P48169"; TRANSMEM 285..305; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P48169"; TRANSMEM 319..341; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P48169"; TRANSMEM 516..538; /note="Helical"; /evidence="ECO:0000250|UniProtKB:P48169
uniprot
proteins