Slc22a4
entrez
30805
canonical
uniprot
Q9Z306
canonical
ensembl
ENSMUSG00000020334
resolver
ensp
ENSMUSP00000020586
resolver
enst
ENSMUST00000020586
resolver
genesymbol
Slc22a4
resolver
genesymbol_syn
Octn1
resolver
uniprot_entry
S22A4_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Allosterically activated by intracellular ATP. {ECO:0000250|UniProtKB:Q9H015}.
uniprot
proteins
amino_acid_sequence
MRDYDEVIAFLGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCLVPDTVNLSSSWRNHSIPLETKDGRQVPQSCRRYRLATIANFSAMGLEPGQDVDLEQLEQESCLDGWEYDKDIFLSTIVTEWNLVCEDDWKTPLTTSLFFVGVLCGSFVSGQLSDRFGRKKVLFATMAVQTGFSFVQIFSTNWEMFTVLFAIVGMGQISNYVVAFILGTEILSKSVRIIFSTLGVCTFFAIGYMVLPLFAYFIRDWRMLLLALTLPGLFCVPLWWFIPESPRWLISQRRFAEAEQIIQKAAKMNSIVAPAGIFDPLELQELNSLKQQKVIILDLFRTRNIATITVMAVMLWMLTSVGYFALSLNVPNLHGDVYLNCFLSGLIEVPAYFTAWLLLRTLPRRYIIAGVLFWGGGVLLLIQVVPEDYNFVSIGLVMLGKFGITSAFSMLYVFTAELYPTLVRNMAVGITSMASRVGSIIAPYFVYLGAYNRLLPYILMGSLTVLIGIITLFFPESFGVTLPENLEQMQKVRGFRCGKKSTVSVDREESPKVLITAF
uniprot
proteins
function
FUNCTION: Transporter that mediates the transport of endogenous and microbial zwitterions and organic cations (PubMed:11010964, PubMed:20224991, PubMed:20601551). Functions as a Na(+)-dependent and pH-dependent high affinity microbial symporter of potent food-derived antioxidant ergothioeine (By similarity). Transports one sodium ion with one ergothioeine molecule (By similarity). Involved in the absorption of ergothioneine from the luminal/apical side of the small intestine and renal tubular cells, and into non-parenchymal liver cells, thereby contributing to maintain steady-state ergothioneine level in the body (PubMed:20224991, PubMed:20601551). Also mediates the bidirectional transport of acetycholine, although the exact transport mechanism has not been fully identified yet (By similarity). Most likely exports anti-inflammatory acetylcholine in non-neuronal tissues, thereby contributing to the non-neuronal cholinergic system (By similarity). Displays a general physiological role linked to better survival by controlling inflammation and oxidative stress, which may be related to ergothioneine and acetycholine transports (PubMed:20224991). May also function as a low-affinity Na(+)-dependent transporter of L-carnitine through the mitochondrial membrane, thereby maintaining intracellular carnitine homeostasis (PubMed:11010964, PubMed:16729965). May contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (By similarity). {ECO:0000250|UniProtKB:Q9H015, ECO:0000250|UniProtKB:Q9R141, ECO:0000269|PubMed:11010964, ECO:0000269|PubMed:16729965, ECO:0000269|PubMed:20224991, ECO:0000269|PubMed:20601551}.
uniprot
proteins
mass_dalton
62290
uniprot
proteins
protein_family
Major facilitator (TC 2.A.1) superfamily
uniprot
proteins
protein_family
Organic cation transporter (TC 2.A.1.19) family
uniprot
proteins
pubmed
11010964
uniprot
proteins
pubmed
14531806
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15832501
uniprot
proteins
pubmed
16729965
uniprot
proteins
pubmed
20224991
uniprot
proteins
pubmed
20601551
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
553
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:15832501, ECO:0000269|PubMed:20601551}; Multi-pass membrane protein {ECO:0000305}. Mitochondrion membrane {ECO:0000269|PubMed:16729965}; Multi-pass membrane protein {ECO:0000305}. Basal cell membrane {ECO:0000250|UniProtKB:Q9H015}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the apical membrane of small intestines (PubMed:20601551). Localized to the apical membrane of cortical proximal tubular epithelial cells in kidney (PubMed:15832501). {ECO:0000269|PubMed:15832501, ECO:0000269|PubMed:20601551}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..41; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 143..163; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 172..192; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 198..218; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 233..253; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 258..278; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 340..360; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 374..394; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 401..421; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 429..449; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 463..483; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 489..509; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins