ABCG4
entrez
64137
canonical
uniprot
Q9H172
canonical
ensembl
ENSG00000172350
resolver
ensp
ENSP00000479253
resolver
ensp
ENSP00000481728
resolver
genesymbol
ABCG4
resolver
genesymbol_syn
WHITE2
resolver
hgnc
HGNC:13884
resolver
uniprot
A8K1B5
resolver
uniprot
Q8WWH0
resolver
uniprot
Q8WWH1
resolver
uniprot
Q8WWH2
resolver
uniprot_entry
ABCG4_HUMAN
resolver
uniprot_sec
A8K1B5
resolver
uniprot_sec
Q8WWH0
resolver
uniprot_sec
Q8WWH1
resolver
uniprot_sec
Q8WWH2
resolver
amino_acid_sequence
MAEKALEAVGCGLGPGAVAMAVTLEDGAEPPVLTTHLKKVENHITEAQRFSHLPKRSAVDIEFVELSYSVREGPCWRKRGYKTLLKCLSGKFCRRELIGIMGPSGAGKSTFMNILAGYRESGMKGQILVNGRPRELRTFRKMSCYIMQDDMLLPHLTVLEAMMVSANLKLSEKQEVKKELVTEILTALGLMSCSHTRTALLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKSLAQGGRTIICTIHQPSAKLFEMFDKLYILSQGQCIFKGVVTNLIPYLKGLGLHCPTYHNPADFIIEVASGEYGDLNPMLFRAVQNGLCAMAEKKSSPEKNEVPAPCPPCPPEVDPIESHTFATSTLTQFCILFKRTFLSILRDTVLTHLRFMSHVVIGVLIGLLYLHIGDDASKVFNNTGCLFFSMLFLMFAALMPTVLTFPLEMAVFMREHLNYWYSLKAYYLAKTMADVPFQVVCPVVYCSIVYWMTGQPAETSRFLLFSALATATALVAQSLGLLIGAASNSLQVATFVGPVTAIPVLLFSGFFVSFKTIPTYLQWSSYLSYVRYGFEGVILTIYGMERGDLTCLEERCPFREPQSILRALDVEDAKLYMDFLVLGIFFLALRLLAYLVLRYRVKSER
uniprot
proteins
ec_number
7.6.2.-
uniprot
proteins
function
FUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that may be involved in the cellular efflux of sterols, in particular cholesterol and desmosterol (a cholesterol precursor), to high-density lipoprotein (HDL) (PubMed:15240127, PubMed:33141061). May play an important role in the removal of amyloid-beta peptides from brain, in a process that can be antagonized by desmosterol. However it is unclear whether ABCG4 can directly transport amyloid-beta peptides or whether peptide export may be facilitated due to changes in the membrane lipid environment (By similarity). Induces apoptosis in various cells (PubMed:27228027). {ECO:0000250|UniProtKB:Q91WA9, ECO:0000269|PubMed:15240127, ECO:0000269|PubMed:27228027, ECO:0000269|PubMed:33141061}.
uniprot
proteins
mass_dalton
71896
uniprot
proteins
mutagenesis
MUTAGEN 108; /note="K->M: Abrogates ATPase activity. Induces a dominant-negative effect on ABCG1 ATP-activity. Does not affect subcellular localization."; /evidence="ECO:0000269|PubMed:15240127, ECO:0000269|PubMed:27228027
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCG family
uniprot
proteins
protein_family
Eye pigment precursor importer (TC 3.A.1.204) subfamily
uniprot
proteins
pubmed
11606068
uniprot
proteins
pubmed
11856881
uniprot
proteins
pubmed
12183068
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15240127
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
27228027
uniprot
proteins
pubmed
33141061
uniprot
proteins
sequence_length
646
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27228027}; Multi-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q91WA9}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000250|UniProtKB:Q91WA9}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 394..414; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 426..446; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 473..493; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 504..524; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 533..553; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 618..638; /note="Helical; Name=6"; /evidence="ECO:0000255
uniprot
proteins