Trpc3
entrez
22065
canonical
uniprot
Q9QZC1
canonical
ensembl
ENSMUSG00000027716
resolver
ensp
ENSMUSP00000029271
resolver
ensp
ENSMUSP00000274390
resolver
enst
ENSMUST00000029271
resolver
genesymbol
Trpc3
resolver
genesymbol_syn
Trp3
resolver
genesymbol_syn
Trrp3
resolver
uniprot
B1ATV3
resolver
uniprot
Q61058
resolver
uniprot
Q8BNT8
resolver
uniprot
Q8CCQ1
resolver
uniprot_entry
Q8BNT8_MOUSE
resolver
uniprot_entry
Q8CCQ1_MOUSE
resolver
uniprot_entry
TRPC3_MOUSE
resolver
uniprot_sec
B1ATV3
resolver
uniprot_sec
Q61058
resolver
activity_regulation
ACTIVITY REGULATION: Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C. Activated by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May be activated by internal calcium store depletion. Inhibited by intracellular Ca(2+). {ECO:0000250|UniProtKB:Q13507}.
uniprot
proteins
amino_acid_sequence
MSTKVKKCREPARVTLPAPEEEEDGEAEGGESQRRRRGWRGVNGGLEPPCPRAPPSPGPDASSEGSPSRWRTAGMRDKGRRQAVRGPAFMFGARGPSLTAEEERFLDAAEYGNIPVVRKMLEESRTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENLARIGDALLLAISKGYVRIVEAILGHPGFAASRRLTLSPCEQELRDDDFYAYDEDGTRFSPDITPIILAAHCHKYEVVHLLLLKGARIERPHDYFCRCSDCAEKQRLDAFSHSRSRINAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGVLDLCRDSEEVEAILNGDLESAEPLERHGHKASLSRVKLAIKYEVKKFVAHPNCQQQLLTIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAHAASFIIFLGLLVFNASDRFEGITTLPNITVIDYPKQIFRVKTTQFTWTEMLIMVWVLGMMWSECKELWLEGPREYIVQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSHVQESDLSEVTLPPEVQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQISLGRTVKDIFKFMVLFIMVFLAFMIGMFILYSYYLGAKVNPAFTTVEESFKTLFWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIEDDSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRITNFSKCRRRRLQKDLELGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKENDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKLNPSVLRCE
uniprot
proteins
function
FUNCTION: Forms a receptor-activated non-selective calcium permeant cation channel. May be operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G protein coupled receptors. {ECO:0000250|UniProtKB:Q13507}.
uniprot
proteins
mass_dalton
103620
uniprot
proteins
protein_family
STrpC subfamily
uniprot
proteins
protein_family
TRPC3 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
8646775
uniprot
proteins
pubmed
9512398
uniprot
proteins
sequence_length
910
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q13507}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 449..466; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13507"; TRANSMEM 498..516; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13507"; TRANSMEM 530..551; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13507"; TRANSMEM 596..619; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13507"; TRANSMEM 639..662; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13507"; TRANSMEM 703..728; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q13507
uniprot
proteins