Prdm1
entrez
12142
canonical
uniprot
Q60636
canonical
ensembl
ENSMUSG00000038151
resolver
ensp
ENSMUSP00000039248
resolver
ensp
ENSMUSP00000101129
resolver
ensp
ENSMUSP00000151237
resolver
genesymbol
Prdm1
resolver
genesymbol_syn
Blimp1
resolver
uniprot
A2VDE8
resolver
uniprot
Q3UET9
resolver
uniprot_entry
PRDM1_MOUSE
resolver
uniprot_sec
A2VDE8
resolver
uniprot_sec
Q3UET9
resolver
amino_acid_sequence
MREAYLRCWIFSWKNVWVRPCQRLHFKTVLLQGSLLYTALDSYSTVQAAPKSSSGSVKFQGLAETGIMKMDMEDADMTLWTEAEFEEKCTYIVNDHPWDSGADGGTSVQAEASLPRNLLFKYAANNSKEVIGVVSKEYIPKGTRFGPLIGEVYTNDTVPKNANRKYFWRIYSREEFHHFIDGFNEEKSNWMRYVNPAHSAREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERLHYPYPGELTVINLTQTESNPKQYSSEKNELYPKSVPKREYSVKEILKLDSNPSKRKDIYRSNISPFTLEKDMDGFRKNGSPDMPFYPRVVYPIRAPLPEDFLKASLAYGMERPTYITHSPLPSSTTPSPPASSSPEQSLKSSSPHSSPGNTVSPLAPGLPEHRDSYSYLNVSYGSEGLGSYPGYAPAPHLPPAFIPSYNAHYPKFLLPPYGISSNGLSTMNNINGINNFSLFPRLYPVYSNLLSGSSLPHPMLNPASLPSSLPTDGARRLLPPEHPKEVLIPAPHSAFSLTGAAASMKDESSPPSGSPTAGTAATSEHVVQPKATSSVMAAPSTDGAMNLIKNKRNMTGYKTLPYPLKKQNGKIKYECNVCAKTFGQLSNLKVHLRVHSGERPFKCQTCNKGFTQLAHLQKHYLVHTGEKPHECQVCHKRFSSTSNLKTHLRLHSGEKPYQCKVCPAKFTQFVHLKLHKRLHTRERPHKCAQCHKSYIHLCSLKVHLKGNCPAGPAAGLPLEDLTRINEEIERFDISDNADRLEDMEDSVDVTSMVEKEILAVVRKEKEETSLKVSLQRNMGNGLLSSGCSLYESSDLSLMKLPHSNPLPLVPVKVKQETVEPMDP
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs (PubMed:27102484). Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (PubMed:27102484). Binds specifically to the PRDI element in the promoter of the beta-interferon gene (By similarity). Drives the maturation of B-lymphocytes into Ig secreting cells (By similarity). Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (PubMed:27102484). Binds to the promoter and acts as a transcriptional repressor of IRF8, thereby promotes transcription of osteoclast differentiation factors such as NFATC1 and EEIG1 (PubMed:32741026). {ECO:0000250|UniProtKB:O75626, ECO:0000269|PubMed:27102484, ECO:0000269|PubMed:32741026}.
uniprot
proteins
mass_dalton
95836
uniprot
proteins
post_translational_modification
PTM: Sumoylation at Lys-847 by PIAS1 increases transcriptional repressor activity, and is critical for plasma cell differentiation (By similarity). Can be sumoylated with SUMO1 and SUMO2 by PML. Degradation of the wild-type protein mostly depends upon sumoylation, rather than ubiquitination (By similarity). Desumoylated by SENP1 and SENP6 (By similarity). {ECO:0000250|UniProtKB:O75626}.; PTM: Ubiquitinated by SCF(FBXO11), leading to its degradation by the proteasome. {ECO:0000250|UniProtKB:O75626}.
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
pubmed
11121475
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16699504
uniprot
proteins
pubmed
19737919
uniprot
proteins
pubmed
27102484
uniprot
proteins
pubmed
32741026
uniprot
proteins
pubmed
8168136
uniprot
proteins
sequence_length
856
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8168136}. Cytoplasm {ECO:0000250|UniProtKB:O75626}.
uniprot
proteins