Q64563
uniprot
Q64563
canonical
activity_regulation
ACTIVITY REGULATION: Oxidation of 20-HETE is inhibited by low concentrations of N-heptylformamide. Oxidation of 20-HETE is a decreased by 55-65% by either all-trans-retinol or all-trans-retinoic acid. Strongly inhibited by omega-hydroxy fatty acids. {ECO:0000250|UniProtKB:Q9QYY9}.
uniprot
proteins
amino_acid_sequence
MGTQGKVITCKAAIAWKTDSPLCIEEIEVSPPKAHEVRIKVIATCVCPTDINATNPKKKALFPVVLGHECAGIVESVGPGVTNFKPGDKVIPFFAPQCKKCKLCLSPLTNLCGKLRNFKYPTIDQELMEDRTSRFTSKERSIYHFMGVSSFSQYTVVSEANLARVDDEANLERVCLIGCGFTSGYGAAINTAKVTPGSACAVFGLGCVGLSAVIGCKIAGASRIIAIDINSEKFPKAKALGATDCLNPRDLDKPVQDVITELTGGGVDFSLDCAGTAQTLKAAVDCTVVGWGSCTVVGAKVDEMNISTVDMILGRSVKGTFFGGWKSVDSVPNLVTDYKNKKFDLDLLVTHALPFDKINDAIDLMNQGKSIRTILTF
uniprot
proteins
ec_number
1.1.1.105
uniprot
proteins
function
FUNCTION: Catalyzes the NAD-dependent oxidation of either all-trans-retinol or 9-cis-retinol (PubMed:17279314). Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate (By similarity). Also catalyzes the reduction of benzoquinones (By similarity). {ECO:0000250|UniProtKB:P08319, ECO:0000269|PubMed:17279314}.
uniprot
proteins
mass_dalton
40277
uniprot
proteins
protein_family
Class-II subfamily
uniprot
proteins
protein_family
Zinc-containing alcohol dehydrogenase family
uniprot
proteins
pubmed
17279314
uniprot
proteins
pubmed
7635195
uniprot
proteins
sequence_length
377
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins