SEC61A2
entrez
55176
canonical
uniprot
Q9H9S3
canonical
ensembl
ENSG00000065665
resolver
ensp
ENSP00000298428
resolver
ensp
ENSP00000302048
resolver
ensp
ENSP00000368319
resolver
ensp
ENSP00000436749
resolver
enst
ENST00000475268
resolver
genesymbol
SEC61A2
resolver
hgnc
HGNC:17702
resolver
uniprot
A8K8D0
resolver
uniprot
B3KQ68
resolver
uniprot
B4DX72
resolver
uniprot
F6QB68
resolver
uniprot
F8W773
resolver
uniprot
Q8TC24
resolver
uniprot_entry
B3KQ68_HUMAN
resolver
uniprot_entry
F6QB68_HUMAN
resolver
uniprot_entry
Q8TC24_HUMAN
resolver
uniprot_entry
S61A2_HUMAN
resolver
uniprot_sec
A8K8D0
resolver
uniprot_sec
B4DX72
resolver
uniprot_sec
F8W773
resolver
amino_acid_sequence
MGIKFLEVIKPFCAVLPEIQKPERKIQFREKVLWTAITLFIFLVCCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEVGDTPKDRALFNGAQKLFGMIITIGQAIVYVMTGMYGDPAEMGAGICLLIIIQLFVAGLIVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTINTGRGTEFEGAVIALFHLLATRTDKVRALREAFYRQNLPNLMNLIATVFVFAVVIYFQGFRVDLPIKSARYRGQYSSYPIKLFYTSNIPIILQSALVSNLYVISQMLSVRFSGNFLVNLLGQWADVSGGGPARSYPVGGLCYYLSPPESMGAIFEDPVHVVVYIIFMLGSCAFFSKTWIEVSGSSAKDVAKQLKEQQMVMRGHRDTSMVHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLAVTIIYQYFEIFVKEQAEVGGMGALFF
uniprot
proteins
function
FUNCTION: Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. {ECO:0000250|UniProtKB:P61619}.
uniprot
proteins
mass_dalton
52248
uniprot
proteins
protein_family
SecY/SEC61-alpha family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
sequence_length
476
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P61619}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 34..53; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 77..96; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 118..138; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 145..165; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 173..193; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 241..261; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 289..309; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 355..375; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 421..441; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 446..462; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins