Plcl1
entrez
84587
canonical
uniprot
Q62688
canonical
ensembl
ENSRNOG00000032659
resolver
ensp
ENSRNOP00000110438
resolver
enst
ENSRNOT00000168724
resolver
genesymbol
Plcl1
resolver
uniprot
A0ABK0M120
resolver
uniprot_entry
A0ABK0M120_RAT
resolver
uniprot_entry
PLCL1_RAT
resolver
amino_acid_sequence
MAEGAASREAPAPLDVAGGEDDPRAGADAASGDAAPEASGGRMRDRRSGVALPGNAGVPADSEAGLLEAARATPRRTSIIKDPSNQKCGGRKKTVSFSSMPSEKKISSAHDCISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGKNTETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKESKIRLKFKEIQKSKEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLFLEVEQGVTHVTEDMCLDIIRRYELSEDGRQKGFLAIDGFTQYLLSPECDIFDPEQKKVAQDMTQPLSHYYINASHNTYLIEDQFRGPADINGYVRALKMGCRSIELDVSDGPDNEPILCNRNNMAMLLSFRSVLEVINKFAFVASEYPLILCLGNHCSLPQQRVMVQQMKKVFGNKLYTEAPLSSESYLPSPEKLKHMIIVKGKKLPSESDLLEGEVTDEDEEAEMSRRVSGDYNGEQKHIWLCRELSDLVSICKSVQYRDFELSMKTQNYWEICSFSETLASRIANEYPEDFVNYNKKFLSRVYPSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDEVSYFSANTKGIVPGVSPLLLHIKIISGQNFPKPKGACAKGDVIDPYVCVEIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNLPELTMVRFVILDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAITNRSGGGKAQKRSLSVRMGKKVREYTMLRNIGLKTIDDIFKIAVHPLREAIDMRENMQNAIVSVKELCGLPPIASLKQCLLTLSSRLITSDSTPSVSLVMKDCFPYLEPLGTIPDVQKRMLAAYDLMIQESRVLIEMADTVQEKIVQCQKAGMEFHEELHNLGAKEGLKGRKLNKAIESFAWNITVLKGQGDLLKNAKNEAVENIKQIQLACLSCGLSKGPGSAAEAKGKRSLEAIEEKESSEENGKL
uniprot
proteins
function
FUNCTION: Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC activity to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol. Component in the phospho-dependent endocytosis process of GABA A receptor. Acts as an inhibitor of PPP1C. {ECO:0000269|PubMed:11278544, ECO:0000269|PubMed:8546702}.
uniprot
proteins
mass_dalton
122772
uniprot
proteins
post_translational_modification
PTM: Phosphorylation of Thr-94 resulted in dissociation of PPP1C from PRIP1 (By similarity). In vitro, phosphorylated by the catalytic subunit of PKA. {ECO:0000250, ECO:0000269|PubMed:11278544}.
uniprot
proteins
protein_family
PRIP family
uniprot
proteins
pubmed
11278544
uniprot
proteins
pubmed
11867528
uniprot
proteins
pubmed
12467885
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8546702
uniprot
proteins
sequence_length
1096
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11278544, ECO:0000269|PubMed:8546702}.
uniprot
proteins