MBL2
entrez
4153
canonical
uniprot
P11226
canonical
ensembl
ENSG00000165471
resolver
ensp
ENSP00000363079
resolver
ensp
ENSP00000502615
resolver
ensp
ENSP00000502789
resolver
ensp
ENSP00000547501
resolver
enst
ENST00000373968
resolver
enst
ENST00000674931
resolver
enst
ENST00000675947
resolver
enst
ENST00000877442
resolver
genesymbol
MBL2
resolver
genesymbol_syn
COLEC1
resolver
genesymbol_syn
MBL
resolver
hgnc
HGNC:6922
resolver
uniprot
Q4VB12
resolver
uniprot
Q4VB13
resolver
uniprot
Q4VB14
resolver
uniprot
Q5SQS3
resolver
uniprot
Q86SI4
resolver
uniprot
Q96KE4
resolver
uniprot
Q96TF7
resolver
uniprot
Q96TF8
resolver
uniprot
Q96TF9
resolver
uniprot_entry
MBL2_HUMAN
resolver
uniprot_sec
Q4VB12
resolver
uniprot_sec
Q4VB13
resolver
uniprot_sec
Q4VB14
resolver
uniprot_sec
Q5SQS3
resolver
uniprot_sec
Q86SI4
resolver
uniprot_sec
Q96KE4
resolver
uniprot_sec
Q96TF7
resolver
uniprot_sec
Q96TF8
resolver
uniprot_sec
Q96TF9
resolver
amino_acid_sequence
MSLFPSLPLLLLSMVAASYSETVTCEDAQKTCPAVIACSSPGINGFPGKDGRDGTKGEKGEPGQGLRGLQGPPGKLGPPGNPGPSGSPGPKGQKGDPGKSPDGDSSLAASERKALQTEMARIKKWLTFSLGKQVGNKFFLTNGEIMTFEKVKALCVKFQASVATPRNAAENGAIQNLIKEEAFLGITDEKTEGQFVDLTGNRLTYTNWNEGEPNNAGSDEDCVLLLKNGQWNDVPCSTSHLAVCEFPI
uniprot
proteins
function
FUNCTION: Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:14515269, PubMed:22966085, PubMed:7634089, PubMed:9087411). Specifically recognizes and binds the mannose moiety of carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway (PubMed:22966085, PubMed:2573758, PubMed:6643429, PubMed:8082295, PubMed:9087411). Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response (PubMed:35102342). May bind DNA (PubMed:15145932). {ECO:0000269|PubMed:14515269, ECO:0000269|PubMed:15145932, ECO:0000269|PubMed:22966085, ECO:0000269|PubMed:2573758, ECO:0000269|PubMed:35102342, ECO:0000269|PubMed:6643429, ECO:0000269|PubMed:7634089, ECO:0000269|PubMed:8082295, ECO:0000269|PubMed:9087411}.
uniprot
proteins
mass_dalton
26144
uniprot
proteins
pubmed
10447262
uniprot
proteins
pubmed
12175909
uniprot
proteins
pubmed
1303250
uniprot
proteins
pubmed
1304173
uniprot
proteins
pubmed
14515269
uniprot
proteins
pubmed
15145932
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15994813
uniprot
proteins
pubmed
16116208
uniprot
proteins
pubmed
1675710
uniprot
proteins
pubmed
18006063
uniprot
proteins
pubmed
21695215
uniprot
proteins
pubmed
22966085
uniprot
proteins
pubmed
23460739
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2450948
uniprot
proteins
pubmed
2477486
uniprot
proteins
pubmed
2573758
uniprot
proteins
pubmed
2590164
uniprot
proteins
pubmed
29563915
uniprot
proteins
pubmed
35102342
uniprot
proteins
pubmed
6643429
uniprot
proteins
pubmed
7634089
uniprot
proteins
pubmed
7982896
uniprot
proteins
pubmed
8082295
uniprot
proteins
pubmed
9087411
uniprot
proteins
pubmed
9743385
uniprot
proteins
sequence_length
248
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7982896}. Cell surface {ECO:0000269|PubMed:22966085, ECO:0000269|PubMed:2573758, ECO:0000269|PubMed:8082295}. Note=Specifically binds mannose moiety of carbohydrates on the surface of pathogens. {ECO:0000269|PubMed:2573758, ECO:0000269|PubMed:6643429, ECO:0000269|PubMed:8082295}.
uniprot
proteins