Slc15a4
entrez
100561
canonical
uniprot
Q91W98
canonical
ensembl
ENSMUSG00000029416
resolver
ensp
ENSMUSP00000031367
resolver
ensp
ENSMUSP00000241317
resolver
enst
ENSMUST00000031367
resolver
genesymbol
Slc15a4
resolver
genesymbol_syn
Pht1
resolver
uniprot
Q7TPL5
resolver
uniprot_entry
S15A4_MOUSE
resolver
uniprot_sec
Q7TPL5
resolver
amino_acid_sequence
MEGERAPLLGSRRPAVSAASAVFAGRRAACGAVLLAELLERAAFYGVTANLVLFLNGAPFDWEGAQASQALLLFMGLTYLGSPFGGWLADARLGRARAILLSLALYLLGLLAFPLLAAPRSRSFLCGDPRPELVRNCSAPFPNGSASCPENAARRCAPATFAGLVLVGLGVATVKANITPFGADQVKDRGPEATRRFFNWFYWSINLGAILSLGGIAYIQQNVSFFTGYLIPTVCVAIAFLVFLCGQSVFITKPPDGSAFTDMFRILTYSCCSQRGGQRRSGEGLGVFQQSSKHSLFDSCKMSRGGPFTEDKVEDVKALVKIVPVFLALIPYWTVYFQMQTTYALQSLHLKIPEISSITTTHHTLPAAWLTMFDAVLILLLIPLKDKLVDPVLRRHGLLPSSLKRIAVGMFFVMCSAFAAGILESKRLDLVKEKTINQTIGGVVYHAADLPIWWQIPQYVLIGISEIFASIAGLEFAYSAAPKSMQSAIMGLFFFFSGIGSFVGSGLLALVSLKAIGWMSSHTDFGNINSCHLHYYFFLLAAIQGATLLLFLIVSVKYDRQRARTDGGPASTRT
uniprot
proteins
function
FUNCTION: Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response (PubMed:19570976, PubMed:21277849, PubMed:25238095, PubMed:27845049, PubMed:29305823). Preferably binds to short peptides with a basic residue at the first position and a hydrophobic residue at the second position (By similarity). Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans (PubMed:29784761). Transporter activity is pH-dependent and maximized in the acidic lysosomal environment (By similarity). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand, and L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (tri-DAP), the NOD1 ligand (PubMed:19570976, PubMed:23028315, PubMed:24695226, PubMed:25238095, PubMed:29784761). Required for TLR7, TLR8 and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs) (PubMed:21045126, PubMed:23382217, PubMed:25238095, PubMed:30262916). Independently of its transporter activity, also promotes the recruitment of innate immune adapter TASL to endolysosome downstream of TLR7, TLR8 and TLR9: TASL recruitment leads to the specific recruitment and activation of IRF5 (By similarity). Required for isotype class switch recombination to IgG2c isotype in response to TLR9 stimulation (PubMed:25310967). Required for mast cell secretory-granule homeostasis by limiting mast cell functions and inflammatory responses (PubMed:29155995). {ECO:0000250|UniProtKB:O09014, ECO:0000250|UniProtKB:Q8N697, ECO:0000269|PubMed:19570976, ECO:0000269|PubMed:21045126, ECO:0000269|PubMed:21277849, ECO:0000269|PubMed:23028315, ECO:0000269|PubMed:23382217, ECO:0000269|PubMed:24695226, ECO:0000269|PubMed:25238095, ECO:0000269|PubMed:25310967, ECO:0000269|PubMed:27845049, ECO:0000269|PubMed:29155995, ECO:0000269|PubMed:29305823, ECO:0000269|PubMed:29784761, ECO:0000269|PubMed:30262916}.
uniprot
proteins
mass_dalton
62256
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19570976
uniprot
proteins
pubmed
21045126
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21277849
uniprot
proteins
pubmed
23028315
uniprot
proteins
pubmed
23382217
uniprot
proteins
pubmed
24695226
uniprot
proteins
pubmed
25238095
uniprot
proteins
pubmed
25310967
uniprot
proteins
pubmed
27845049
uniprot
proteins
pubmed
29155995
uniprot
proteins
pubmed
29305823
uniprot
proteins
pubmed
29784761
uniprot
proteins
pubmed
30262916
uniprot
proteins
sequence_length
574
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:21277849, ECO:0000269|PubMed:24695226, ECO:0000269|PubMed:29155995}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8N697}. Endosome membrane {ECO:0000269|PubMed:24695226, ECO:0000269|PubMed:29784761}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8N697}. Early endosome membrane {ECO:0000269|PubMed:19570976}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8N697}.
uniprot
proteins
transmembrane_region
TRANSMEM 29..55; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q8N697"; TRANSMEM 70..89; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q8N697"; TRANSMEM 98..118; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q8N697"; TRANSMEM 159..179; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q8N697"; TRANSMEM 197..219; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q8N697"; TRANSMEM 226..246; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q8N697"; TRANSMEM 318..339; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q8N697"; TRANSMEM 368..393; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q8N697"; TRANSMEM 406..423; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q8N697"; TRANSMEM 456..476; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q8N697"; TRANSMEM 488..511; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q8N697"; TRANSMEM 537..554; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:Q8N697
uniprot
proteins