Gabra6
entrez
29708
canonical
uniprot
P30191
canonical
ensembl
ENSRNOG00000003569
resolver
ensp
ENSRNOP00000004877
resolver
enst
ENSRNOT00000004877
resolver
genesymbol
Gabra6
resolver
genesymbol_syn
Gabra-6
resolver
uniprot
G3V6G3
resolver
uniprot_entry
G3V6G3_RAT
resolver
uniprot_entry
GBRA6_RAT
resolver
amino_acid_sequence
MLLLLPWLFSLLWIENAQAQLEDEGNFYSENVSRILDNLLEGYDNRLRPGFGGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFKGPAEILSLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRLMHNGTILYTMRLTINADCPMRLVNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQTVSSETIKSNTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFGITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNLQSQKAERQAQTAAKPPVAKSKTTESLEAEIVVHSDSKYHLKKRISSLTLPIVPSSEASKVLSRTPILPSTPVTPPLLLPAIGGTSKIDQYSRILFPVAFAGFNLVYWIVYLSKDTMEVSSTVE
uniprot
proteins
function
FUNCTION: Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain (PubMed:2166916, PubMed:9464994). GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s) (By similarity). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient (By similarity). Alpha-6/GABRA6 subunits are found at both synaptic and extrasynaptic sites (PubMed:2166916, PubMed:9464994). Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission (By similarity). Extrasynaptic alpha-6-containing receptors contribute to the tonic GABAergic inhibition (PubMed:9464994). Alpha-6 subunits are also present on glutamatergic synapses (PubMed:9464994). {ECO:0000250|UniProtKB:P08219, ECO:0000250|UniProtKB:P14867, ECO:0000269|PubMed:2166916, ECO:0000269|PubMed:9464994}.
uniprot
proteins
mass_dalton
51184
uniprot
proteins
protein_family
GABRA6 sub-subfamily
uniprot
proteins
protein_family
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
2166916
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9464994
uniprot
proteins
sequence_length
453
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000269|PubMed:9464994}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:9464994}; Multi-pass membrane protein {ECO:0000255}. Note=Present in Golgi synapses, on the extrasynaptic membranes, and in some of the mossy fiber to granule cell synapses (PubMed:9464994). Also found on the extrasynaptic somatic and dendritic membranes (PubMed:9464994). {ECO:0000269|PubMed:9464994}.
uniprot
proteins
transmembrane_region
TRANSMEM 244..264; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 271..290; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 305..325; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 423..443; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins