Rad21
entrez
19357
canonical
uniprot
Q61550
canonical
ensembl
ENSMUSG00000022314
resolver
ensp
ENSMUSP00000022927
resolver
ensp
ENSMUSP00000280559
resolver
enst
ENSMUST00000022927
resolver
genesymbol
Rad21
resolver
genesymbol_syn
Hr21
resolver
genesymbol_syn
Scc1
resolver
uniprot
P70219
resolver
uniprot
Q3TG35
resolver
uniprot
Q3TQ09
resolver
uniprot
Q810A8
resolver
uniprot
Q91VB9
resolver
uniprot
Q9DBU4
resolver
uniprot_entry
Q3TG35_MOUSE
resolver
uniprot_entry
RAD21_MOUSE
resolver
uniprot_sec
P70219
resolver
uniprot_sec
Q3TQ09
resolver
uniprot_sec
Q810A8
resolver
uniprot_sec
Q91VB9
resolver
uniprot_sec
Q9DBU4
resolver
amino_acid_sequence
MFYAHFVLSKRGPLAKIWLAAHWDKKLTKAHVFECNLESSVESIISPKVKMALRTSGHLLLGVVRIYHRKAKYLLADCNEAFIKIKMAFRPGVVDLPEENREAAYNAITLPEEFHDFDQPLPDLDDIDVAQQFSLNQSRVEEITMREEVGNISILQENDFGDFGMDDREIMREGSAFEDDDMLVSTSASNLLLEPEQSTSNLNEKMNHLEYEDQYKDDNFGEGNDGGILDDKLISNNDGGIFDDPPALSEAGVMLPEQPAHDDMDEDDNGSLGGPDSPDSVDPVEPMPTMTDQTTLVPNEEEAFALEPIDITVKETKAKRKRKLIVDSVKELDSKTIRAQLSDYSDIVTTLDLAPPTKKLMMWKETGGVEKLFFLPAQPLWNNRLLKLFTRCLTPLVPEDLRKRRKGGEADNLDEFLKEFENPEVPREEQQPQQQQPQPQRDVIDEPIIEEPSRLQDSVMEASRTTIEESAMPPPPPQGVKRKAGQIDPEPSIPPQQVEQMEIPPVELPPEEPPNICQLIPELELLPEKEKEKEKEKEEEEEEEDEDASGGDQDQEERRWNKRTQQMLHGLQRALAKTGAESISLLELCRNTNRKQAAAKFYSFLVLKKQQAIELTQEEPYSDIIATPGPRFHII
uniprot
proteins
function
FUNCTION: [Double-strand-break repair protein rad21 homolog]: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis (By similarity). In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome (PubMed:18237772). May control RUNX1 gene expression. Binds to and represses APOB gene promoter (By similarity). May play a role in embryonic gut development, possibly through the regulation of enteric neuron development (By similarity). {ECO:0000250|UniProtKB:O60216, ECO:0000250|UniProtKB:Q6TEL1, ECO:0000269|PubMed:18237772}.; FUNCTION: [64-kDa C-terminal product]: May promote apoptosis. {ECO:0000250|UniProtKB:O60216}.
uniprot
proteins
mass_dalton
72083
uniprot
proteins
post_translational_modification
PTM: Cleaved by separase/ESPL1 at the onset of anaphase; this cleavage is required for sister chromatid separation and cytokinesis. Cleaved by caspase-3/CASP3 or caspase-7/CASP7 at the beginning of apoptosis. {ECO:0000250|UniProtKB:O60216}.; PTM: Phosphorylated; becomes hyperphosphorylated in M phase of cell cycle. The large dissociation of cohesin from chromosome arms during prophase may be partly due to its phosphorylation by PLK1. {ECO:0000250|UniProtKB:O60216}.
uniprot
proteins
protein_family
Rad21 family
uniprot
proteins
pubmed
10375619
uniprot
proteins
pubmed
11471062
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
18237772
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8521526
uniprot
proteins
pubmed
8812457
uniprot
proteins
sequence_length
635
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Double-strand-break repair protein rad21 homolog]: Nucleus {ECO:0000269|PubMed:10375619}. Chromosome {ECO:0000269|PubMed:10375619}. Chromosome, centromere {ECO:0000250|UniProtKB:O60216}. Note=Associates with chromatin. Before prophase, scattered along chromosome arms. During prophase and prometaphase, most cohesins dissociate from the arms of condensing chromosome, possibly through PLK1-mediated phosphorylation (By similarity). A small amount of cohesin remains in centromeric regions and is removed from chromosomes only at the onset of anaphase. At anaphase, cleavage by separase/ESPL1 leads to the dissociation of cohesin from chromosomes and chromosome separation (By similarity). {ECO:0000250|UniProtKB:O60216, ECO:0000250|UniProtKB:O93310}.; SUBCELLULAR LOCATION: [64-kDa C-terminal product]: Cytoplasm, cytosol {ECO:0000250|UniProtKB:O60216}. Nucleus {ECO:0000250|UniProtKB:O60216}.
uniprot
proteins