PRKAB2
entrez
5565
canonical
uniprot
O43741
canonical
ensembl
ENSG00000131791
resolver
ensp
ENSP00000254101
resolver
ensp
ENSP00000566060
resolver
ensp
ENSP00000645512
resolver
ensp
ENSP00000645520
resolver
genesymbol
PRKAB2
resolver
hgnc
HGNC:9379
resolver
uniprot
A8K9V5
resolver
uniprot
B4DH06
resolver
uniprot
Q5VXY0
resolver
uniprot
X5D2Z8
resolver
uniprot_entry
AAKB2_HUMAN
resolver
uniprot_entry
X5D2Z8_HUMAN
resolver
uniprot_sec
A8K9V5
resolver
uniprot_sec
B4DH06
resolver
uniprot_sec
Q5VXY0
resolver
amino_acid_sequence
MGNTTSDRVSGERHGAKAARSEGAGGHAPGKEHKIMVGSTDDPSVFSLPDSKLPGDKEFVSWQQDLEDSVKPTQQARPTVIRWSEGGKEVFISGSFNNWSTKIPLIKSHNDFVAILDLPEGEHQYKFFVDGQWVHDPSEPVVTSQLGTINNLIHVKKSDFEVFDALKLDSMESSETSCRDLSSSPPGPYGQEMYAFRSEERFKSPPILPPHLLQVILNKDTNISCDPALLPEPNHVMLNHLYALSIKDSVMVLSATHRYKKKYVTTLLYKPI
uniprot
proteins
function
FUNCTION: Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3).
uniprot
proteins
mass_dalton
30302
uniprot
proteins
mutagenesis
MUTAGEN 235; /note="H->A: Results in an AMPK enzyme that is activable by phosphorylation but has significantly increased rate of dephosphorylation in phosphatase assays."; /evidence="ECO:0000269|PubMed:21399626
uniprot
proteins
post_translational_modification
PTM: Phosphorylated when associated with the catalytic subunit (PRKAA1 or PRKAA2). Phosphorylated by ULK1 and ULK2; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1, ULK2 and AMPK. {ECO:0000269|PubMed:21460634}.
uniprot
proteins
protein_family
5'-AMP-activated protein kinase beta subunit family
uniprot
proteins
pubmed
12490143
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17307971
uniprot
proteins
pubmed
17712357
uniprot
proteins
pubmed
17851531
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21399626
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21460634
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9575201
uniprot
proteins
sequence_length
272
uniprot
proteins