Helq
entrez
191578
canonical
uniprot
Q2VPA6
canonical
ensembl
ENSMUSG00000035266
resolver
ensp
ENSMUSP00000041599
resolver
ensp
ENSMUSP00000116470
resolver
ensp
ENSMUSP00000289278
resolver
ensp
ENSMUSP00000289296
resolver
ensp
ENSMUSP00000289303
resolver
ensp
ENSMUSP00000342119
resolver
genesymbol
Helq
resolver
genesymbol_syn
Hel308
resolver
uniprot
Q2VPA7
resolver
uniprot
Q640L4
resolver
uniprot
Q8BWI5
resolver
uniprot
Q8R4K9
resolver
uniprot_entry
HELQ_MOUSE
resolver
uniprot_sec
Q2VPA7
resolver
uniprot_sec
Q640L4
resolver
uniprot_sec
Q8BWI5
resolver
uniprot_sec
Q8R4K9
resolver
amino_acid_sequence
MEDGCPRIRRRVSVRKRNRGNLENLRASPTPAELQPAEDTEDEAAAGSRRRKTGSPEHAQENDSEEDMFGDYDSFTESSFLAHVDDLEQRYMQLPECGDRDADSGTKDLCSAGLKNNLRVTTVINLTDPETSEHGQKQSHLDVPAEPEPGSDLSFDVPSSQILYFENPQNSPEALGDPCTKKTNGDPQKSSHEELVSSHTEQPEPNNDFSNVRAASESSRRKSLKDHLKSTMAGNARAQTPAFPRSKHLREALLSEEISVAKKAIESPSDDLGPFYSLPSKVRDLYVQLKGIKKLYDWQHTCLTLRSVQERKNLIYSLPTSGGKTLVAEILMLQELLCRQKDVLMILPYVAIVQEKISSLSSFGIELGFFVEEYAGSKGRFPPIKRREKKSLYIATIEKAHSLVNALIETSRLSTLGLVVVDELHMIGEGSRGAILEMTLAKVLYTSKTTQIIGMSATLNNVEDLQAFLKAEYYTSQFRPVELKEFLKVNDTIYEVDSQAADGMTFSRLLSYKYSEALKKMDPDRLVALVTEVIPNYSCLVFCPSKKNCENVAEMLCKFLSKDYLNHREKEKCEVIKSLRNIGNGKVCPVLKRTVPFGIAYHHSGLTSEERKLLEEAYSTGVLCLLTCTSTLAAGVNLPARRVILRAPYVANTFLKRNQYKQMVGRAGRAGIDTAGESILLLQEKDKQQVLELISGPLETCCSHLVEEFTKGIQALFLSLIGLKIAASLGDIYQFMSGTFFGVQQKILLKEKSLWEITVDALEHLTEKGLLQKDSCGDNEGLECHFRITKLGQASFKGAIDLAYCDTLYRDLKKGLEGLVLESLLHLIYLTTPYDLAAQSEPDWMVYFKQFGQLSPTEQNVAALLGVSESFIGKKAAGQAVRKKVDKNVVNRLYLSFVLYSLLKETNVWSVSEKFNLPRGYIQNLLMGAASFSSCVLHFCEELEEFWVYKALLVELTKKLTYCVKAELIPLMEVTGVLEGRAKQLYNAGYRSIMHLANANPEVLVKTIDHLSRRQARQIVSSAKMLLHEKAEALQGEAEELLRLPADLPGLGGPSSERAGSHAGDVTLS
uniprot
proteins
ec_number
5.6.2.4
uniprot
proteins
function
FUNCTION: Single-stranded 3'-5' DNA helicase that plays a key role in homology-driven double-strand break (DSB) repair (PubMed:24005041, PubMed:24005329). Involved in different DSB repair mechanisms that are guided by annealing of extensive stretches of complementary bases at break ends, such as microhomology-mediated end-joining (MMEJ), single-strand annealing (SSA) or synthesis-dependent strand annealing (SDSA) (By similarity). Possesses both DNA unwinding and annealing activities (By similarity). Forms a complex with RAD51, stimulating HELQ DNA helicase activity and ability to unwing DNA (By similarity). Efficiently unwinds substrates containing 3' overhangs or a D-loop (By similarity). In contrast, interaction with the replication protein A (RPA/RP-A) complex inhibits DNA unwinding by HELQ but strongly stimulates DNA strand annealing (By similarity). Triggers displacement of RPA from single-stranded DNA to facilitate annealing of complementary sequences (By similarity). {ECO:0000250|UniProtKB:Q8TDG4, ECO:0000269|PubMed:24005041, ECO:0000269|PubMed:24005329}.
uniprot
proteins
mass_dalton
119098
uniprot
proteins
protein_family
Helicase family
uniprot
proteins
protein_family
SKI2 subfamily
uniprot
proteins
pubmed
11751861
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24005041
uniprot
proteins
pubmed
24005329
uniprot
proteins
sequence_length
1069
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8TDG4}. Chromosome {ECO:0000250|UniProtKB:Q8TDG4}. Note=Localizes to sites of DNA damage; localizes to damaged replication forks. {ECO:0000250|UniProtKB:Q8TDG4}.
uniprot
proteins