Ssh2
entrez
237860
canonical
uniprot
Q5SW75
canonical
ensembl
ENSMUSG00000037926
resolver
ensp
ENSMUSP00000042625
resolver
ensp
ENSMUSP00000137933
resolver
ensp
ENSMUSP00000259728
resolver
enst
ENSMUST00000181283
resolver
genesymbol
Ssh2
resolver
genesymbol_syn
Kiaa1725
resolver
genesymbol_syn
Ssh2l
resolver
uniprot
A0A0R4J2A0
resolver
uniprot
B9EJ94
resolver
uniprot
Q3TDK8
resolver
uniprot
Q3TYP8
resolver
uniprot
Q3U2K3
resolver
uniprot
Q5F268
resolver
uniprot
Q5SW74
resolver
uniprot
Q69ZC3
resolver
uniprot
Q76I78
resolver
uniprot_entry
A0A0R4J2A0_MOUSE
resolver
uniprot_entry
SSH2_MOUSE
resolver
uniprot_sec
B9EJ94
resolver
uniprot_sec
Q3TDK8
resolver
uniprot_sec
Q3TYP8
resolver
uniprot_sec
Q3U2K3
resolver
uniprot_sec
Q5F268
resolver
uniprot_sec
Q5SW74
resolver
uniprot_sec
Q69ZC3
resolver
uniprot_sec
Q76I78
resolver
amino_acid_sequence
MALVTVQRSPTPSTTSSPCASEADSGEEECRSQPRSISESFLTVKGAALFLPRGNGSSTPRVSHRRNKHAGDLQQHLQAMFILLRPEDNIRLAVRLESTYQNRTRYMVVVSTNGRQDTEESIVLGMDFSSNDSSTCTMGLVLPLWSDTLIHLDGDGGFSVSTDNRVHIFKPVSVQAMWSALQSLHKACEVARMHNYYPGSLFLTWVSYYESHINSDQSSVNEWNAMQDVQSHRPDSPALFTDIPTERERTERLIKTKLREIMMQKDLENITSKEIRTELEMQMVCNLREFKEFIDNEMIVILGQMDSPTQIFEHVFLGSEWNASNLEDLQNRGVRYILNVTREIDNFFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIAYAMKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQGILLASKQRHNKLWRSHSDSDLSDHHEPICKPGLELNKKEMTTSADQIAEVKTVENLAAMPTVFMEHVVPQDANQKGLHTKERVICLEFSSQEFRAGQIEDELNLNDINGCSSGCCLSESKLPLDNCHASKALLQPGQAPDIANKFPDLAVEDLETDALKADMNVHLLPMEELTSRLKDLPMSPDLESPSPQASCQAAISDFSTDRIDFFSALEKFVELSQETRSRSFSHSRIEELGGGRSEGCRLSVIEVAASEMAADDQRSSSLSNTPHASEESSVDEDQSKAITELVSPDIIMQSHSENAISVKEIVTEIESISQGVGQVQLKGDILSNPCHTPKKSTIHELPLERVPAPESKPGHWEQDESFCSVQPELARDSGKCAPEEGCLTTHSSTADLEEEEPVEGEHDWGPGMHSGAKWCPGSVRRATLEFEERLRQEQENHGTASAGPTLSNRKNSKNDSSVADLMPKWKSDETTPEHSFFLKEAEPSKGKGKCSGSEAGSLSHCERNPTMPDCELLEHHSLPAPQDCLGSDSRSKKQEGDLKKQRAVVPNQECDTQAILLPLPKKIEIIEYTPTVTSLGHTEPGGEATPSKEGEKQGLRKVKMEQSITMFCALDENLNRTLEPSQVSLHPQVLPLPHSSSECDRPADPNPMLSSPQDKGDCPSTPFKTAAPFVSCSTQGASFSLDYLLPHSVVHLEGCTEQSSATDNELSPEQASWEDSRGHFLSSGSGMAHTSSPLTNEDLSLINKLGDSVGVLQKKLDPSPEACRIPHSSSSENIRDLSHSRGVVKEHAKEIESRVIFQAGFSKTSQMKRSASLAKLGYLDLCKDYLPDRELVSSESPHLKLLQPFLRTDSGMHALMAHEPSESAGAQQNPQPTKYSVEQLKTSECIVQSKPVERPSVQYAKEFGYSQQCLLPKARPELTSSEGGLPLLQTQGLQYTGPSPGLAVAPRQQHGRTHPLRRLKRANDKKRTTNPFYNTM
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein (PubMed:14531860). Required for spermatogenesis (PubMed:36942942). Involved in acrosome biogenesis, probably by regulating cofilin-mediated actin cytoskeleton remodeling during proacrosomal vesicle fusion and/or Golgi to perinuclear vesicle trafficking (PubMed:36942942). {ECO:0000269|PubMed:14531860, ECO:0000269|PubMed:36942942}.
uniprot
proteins
mass_dalton
158230
uniprot
proteins
mutagenesis
MUTAGEN 392; /note="C->S: Abrogates phosphatase activity."; /evidence="ECO:0000269|PubMed:14531860
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
pubmed
14531860
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15368895
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
36942942
uniprot
proteins
sequence_length
1423
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:36942942}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:14531860}. Cell junction, focal adhesion {ECO:0000269|PubMed:14531860}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:36942942}. Note=Colocalizes with filamentous actin in the cytoplasm and the cell periphery. {ECO:0000269|PubMed:14531860}.
uniprot
proteins