Rif1
entrez
51869
canonical
uniprot
Q6PR54
canonical
ensembl
ENSMUSG00000036202
resolver
ensp
ENSMUSP00000108313
resolver
ensp
ENSMUSP00000305928
resolver
ensp
ENSMUSP00000305929
resolver
genesymbol
Rif1
resolver
uniprot
Q6T8D9
resolver
uniprot
Q7TPD8
resolver
uniprot
Q8BTU2
resolver
uniprot
Q8C408
resolver
uniprot
Q9CS77
resolver
uniprot_entry
RIF1_MOUSE
resolver
uniprot_sec
Q6T8D9
resolver
uniprot_sec
Q7TPD8
resolver
uniprot_sec
Q8BTU2
resolver
uniprot_sec
Q8C408
resolver
uniprot_sec
Q9CS77
resolver
amino_acid_sequence
MTAPGRSPLEPLLETWEDPSVPPGEQTDAYLTLTSRMTGEEGKEVIAEIEKNLSRLYTVLKAHISSQNSELSSAALQALGFCLYNPRITSGLSEANIQELLLTLNGIIKSSDKNVCTRALWVISKQTFPAELVSKMVSSIIDSLEVILSKGEIHSAVVDFEALNVIIRLIEQAPVQMGEESVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEIALITEHLMTTKLISELQKLFKNKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQLEELGFRSGTPMIKKIAFIAWKSLIDNFALNPDILCSAKRLKLLMQPLSSIHVRTETLALTKLEVWWYLLMRLGPQLPANFEQVCVPLIQSTISVDSIPSPQGNSSRGSASPGLSPLTPGHKGASPYGSPRGNLSSNTGGMAAIPSIQLLGLEMMLHFLLGPEVLSFAKQHKIVLSLEPLEHPLISSPSFFSKYAHTLITAVHDSFVSVGKDASDAVVSAIWKELISLVKSVTEAGNRKEKSGSEVLTLLLKSLENIVKSEVFPVSKTLVLMEITVKGLPPKVLGSPAYQVANMDILNGTPALFLIQLIFNNNLLECGVEDEKFFLNLETLVGCVLSGPTSPLAFSDSVLTVINQNAKQLVNKEHLWRMWSMIVSPLTDVIHQTNEVNQGDALEHNFSAIYGALTLPINHIFSAQTFPTGTMKALLKTWSELYRAFTRCASLVATAEENLCCEELSSKIMCSLEDEVLSDLLFLDRISHIIIVMVDCIDFSPYNKKYQPKIKSPQRSSDWSRKKKEPLGKLASLFKLIVKVIDTFHTLSLKETFSDTLLAIGNSIISMLSNVFGHISLPSMIREIFATFTRPLALLYENSKLDEAPKVYTSLNNKLEKLLGEIVACLQFSYLGAYDSELLEHLSPLLCVIFLHKNKQIRKQSALLWNATFAKATALVYPEELKPILRQAKQKILLLLPGLENVEMMDESSEPYSESTENSQLNVKISGMERKSSGKRDSILAHTKDKKKKVKLSAKLKLESSSPKIKSGKLLEEEKSTDFVFIPPEGKETKARVLTEHQKEVLKTKRCDIPALYNNLDASQDTLFSAQFSQEESMESLTLTEKPKEDAKIIKEEQMESTIFIHQDAPENCGIDEHSENASLPNCGGSVAETNPETLITGFDARKEVLISSKILSAESSSSTETSVVSSSSVSNATFSGTPPQPTSRRQTFITLEKFDGSETRPFSPSPLNNISSTVTVRNNQDNTTNTDMPPKARKREVTNSKSDSENLANAGKKSSRRWSKAEQSVTKKSKPSLTSEQEEHSSENNSPDLLSPTEHVSENDDHPSEATLEHKDGDPKPAVENASLEDLTTEEKNVGINMESKESTASVVARTEQIVNEDSQAAALAPNPKTLRRSSRRRSEAVDSCSDSQERESGQQKKERRKEEEKIISKSPLRIKDDKLPTQKLTDESPIQENLTEKGNTLPERTSGEPSVNAEIDQNRRKPDLENVSSEGGGGTLDNLDKSSEKPLRGRTRYQTRRASQGLISAVENSESDSSEAKEEVSRKKRSGKWKNRSSDSVDIEEQEEKKAEEEVMKTANQTLDGQAVPDVDVNAAAQVCEKSTNNNRVILQDSAGPADSLQAPPKGEEKSKINKCVDSSFVSLPVPESNLRTRNASKRLLYKQDNDSNVRVSDSSLSPEKFTQVECQHKRSRRVRRSKSCDCCGEKSQSQEKSFIGLKNTESYAIKSVEKKKTDLQVPETAPETREARDHAETKLAGEEPLVNFHVGLKEENCTTGDSVKSEAELQEASLPPEIVTVKEKTYDTDASEAVSEIQGPCSENHSPAEDPGLSECKDISQKQLSENGELDISDVGKACKVIAGSSPEGVETMELNVRNDAFVAADSEKSTQMDVSVDVATEEDNKKDECEAVTTEVNVEGVATEDFNSGMDLSDTPIPVSKDVETEHAASGEIEGESNESDSGSCEEMNKEMGSHKAQMSTEIDSARVKETDILASASKSEEALIGRLDVNTQSFVSDIEMSSGERTVNCKTETSIELNKLDEAKLSGNEATVGNDTLQEVCFTSEKVEKLPQCLLVQVASELGAESNTTSPEKLELDSFGSVNESPSGMQQARCVWSPLASPSTSILKRGLKRSQEDEISPVNKIRRVSFADPIYQAGLADDIDRRCSVVRSHSSNSSPIIKSVKTSPTSHSKHNTTSAKGFLSPGSQSSKFKSPKKCLITEMAQESMLSPTESVYPALVNCAASVDIILPQITSNMWARGLGQLIRAKNIKTIGDLSTLTASEIKTLPIRSPKVFNVKKALRVYHEQQMKSRGLEEIPIFDISEKAVNGVESRTVSTDEERFASDLIEPVTLDTPLSKNLVAQISALALQLDSEDLYSYTGSQLFEMHEKLGTMANSIIRNLQSRWRSPAHENS
uniprot
proteins
function
FUNCTION: Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs (PubMed:23306437, PubMed:23306439, PubMed:23333305). In response to DNA damage, interacts with ATM-phosphorylated TP53BP1 (PubMed:23306437, PubMed:23306439, PubMed:23333305). Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (By similarity). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs (PubMed:23306437, PubMed:23333305). In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase (PubMed:23306437, PubMed:23333305). Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs (PubMed:23306439, PubMed:23333305, PubMed:23333306). Promotes NHEJ of dysfunctional telomeres (PubMed:23333305). {ECO:0000250|UniProtKB:Q5UIP0, ECO:0000269|PubMed:23306437, ECO:0000269|PubMed:23306439, ECO:0000269|PubMed:23333305, ECO:0000269|PubMed:23333306}.
uniprot
proteins
mass_dalton
266228
uniprot
proteins
protein_family
RIF1 family
uniprot
proteins
pubmed
15042697
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23306437
uniprot
proteins
pubmed
23306439
uniprot
proteins
pubmed
23333305
uniprot
proteins
pubmed
23333306
uniprot
proteins
sequence_length
2419
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15042697}. Chromosome {ECO:0000269|PubMed:23306437, ECO:0000269|PubMed:23306439, ECO:0000269|PubMed:23333305}. Chromosome, telomere {ECO:0000269|PubMed:15042697}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q5UIP0}. Note=Exhibits ATM- and TP53BP1-dependent localization to uncapped or aberrant telomeres and to DNA double strand breaks (DSBs). Following interaction with TP53BP1, recruited to sites of DNA damage, such as DSBs (PubMed:23306437, PubMed:23306439, PubMed:23333305). Localizes to microtubules of the midzone of the mitotic spindle during anaphase, and to condensed chromosomes in telophase (By similarity). While the majority of the protein appears nuclear and distinct from normal telomere structures, a small fraction may bind to telomeres in embryonic stem cells (PubMed:15042697). {ECO:0000250|UniProtKB:Q5UIP0, ECO:0000269|PubMed:15042697, ECO:0000269|PubMed:23306437, ECO:0000269|PubMed:23306439, ECO:0000269|PubMed:23333305}.
uniprot
proteins