Il33
entrez
361749
canonical
uniprot
Q66H70
canonical
ensembl
ENSRNOG00000016456
resolver
ensembl
ENSRNOG00055003162
resolver
ensembl
ENSRNOG00055031646
resolver
ensembl
ENSRNOG00060004336
resolver
ensembl
ENSRNOG00060027121
resolver
ensembl
ENSRNOG00065009334
resolver
ensembl
ENSRNOG00065026902
resolver
ensp
ENSRNOP00000022056
resolver
ensp
ENSRNOP00000108288
resolver
ensp
ENSRNOP00000110234
resolver
ensp
ENSRNOP00055003650
resolver
ensp
ENSRNOP00055045283
resolver
ensp
ENSRNOP00060005538
resolver
ensp
ENSRNOP00060039145
resolver
ensp
ENSRNOP00065011157
resolver
ensp
ENSRNOP00065038065
resolver
enst
ENSRNOT00000161772
resolver
enst
ENSRNOT00055004926
resolver
enst
ENSRNOT00055054793
resolver
enst
ENSRNOT00060007300
resolver
enst
ENSRNOT00060047065
resolver
enst
ENSRNOT00065014931
resolver
enst
ENSRNOT00065046425
resolver
genesymbol
Il33
resolver
uniprot_entry
IL33_RAT
resolver
amino_acid_sequence
MRPRMKYSNSKISPAKCDSTSGRALVPPCKITRSQQKTKDICHVYCMRLRSGLTIRKETCYFGKEPAKRYSLKSGSKHEGRLSTCLPDSRKRSLLGSIQAFAASVDTLSIQGTSLLTESCALSTYNDQSVSFVLENGCYVINVEDCGKNQEKDKVLLRYYESSFPAQSGDGVDGKKLMVNMSPIKDTDIWLNANDKDYSVELQKGDVSPPDQAFFVLHKKSSDFVSFECKNLPGTYIGVKDNQLALVEENDESCNNIMFKLSKM
uniprot
proteins
function
FUNCTION: Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (By similarity). Induces rapid UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (By similarity). {ECO:0000250|UniProtKB:O95760, ECO:0000250|UniProtKB:Q8BVZ5}.; FUNCTION: In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or pro-inflammatory activation (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
29486
uniprot
proteins
post_translational_modification
PTM: The full-length protein can be released from cells and is able to signal via the IL1RL1/ST2 receptor. However, proteolytic processing by CELA1, CSTG/cathepsin G and ELANE/neutrophil elastase produces C-terminal peptides that are more active than the unprocessed full-length protein. May also be proteolytically processed by calpains. Proteolytic cleavage mediated by apoptotic caspases including CASP3 and CASP7 results in IL33 inactivation. In vitro proteolytic cleavage by CASP1 was reported but could not be confirmed in vivo suggesting that IL33 is probably not a direct substrate for that caspase (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
IL-1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
264
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O95760}. Chromosome {ECO:0000250|UniProtKB:O95760}. Cytoplasm {ECO:0000250|UniProtKB:O95760}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250|UniProtKB:O95760}. Secreted {ECO:0000250|UniProtKB:O95760}. Note=Associates with heterochromatin and mitotic chromosomes. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion. {ECO:0000250|UniProtKB:O95760}.
uniprot
proteins