Tarbp2
entrez
21357
canonical
uniprot
P97473
canonical
ensembl
ENSMUSG00000023051
resolver
ensp
ENSMUSP00000023813
resolver
ensp
ENSMUSP00000097744
resolver
ensp
ENSMUSP00000121748
resolver
ensp
ENSMUSP00000123339
resolver
enst
ENSMUST00000023813
resolver
enst
ENSMUST00000100168
resolver
genesymbol
Tarbp2
resolver
genesymbol_syn
Prbp
resolver
uniprot
F6ZUR0
resolver
uniprot
Q3UNH9
resolver
uniprot
Q99M41
resolver
uniprot_entry
F6ZUR0_MOUSE
resolver
uniprot_entry
Q3UNH9_MOUSE
resolver
uniprot_entry
TRBP2_MOUSE
resolver
uniprot_sec
Q99M41
resolver
amino_acid_sequence
MSEEDQGSGTTTGCGLPSIEQMLAANPGKTPISLLQEYGTRIGKTPVYDLLKAEGQAHQPNFTFRVTVGDTSCTGQGPSKKAAKHKAAEVALKHLKGGSMLEPALEDSSSFSLLDSSPPEDTPVVAAEAAAPVPSAVLTRSPPMEMQPPVSPQQSECNPVGALQELVVQKGWRLPEYMVTQESGPAHRKEFTMTCRVERFIEIGSGTSKKLAKRNAAAKMLLRVHTVPLDARDGNEAEPDDDHFSIGVSSRLDGLRNRGPGCTWDSLRNSVGEKILSLRSCSVGSLGALGSACCSVLSELSEEQAFHVSYLDIEELSLSGLCQCLVELSTQPATVCYGSATTREAARGDAAHRALQYLRIMAGSK
uniprot
proteins
function
FUNCTION: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1 (By similarity). Binds in vitro to the PRM1 3'-UTR (PubMed:8649414). Seems to act as a repressor of translation (PubMed:8649414). For some pre-miRNA substrates, may also alter the choice of cleavage site by DICER1 (PubMed:23063653). Negatively regulates IRF7-mediated IFN-beta signaling triggered by viral infection by inhibiting the phosphorylation of IRF7 and promoting its 'Lys'-48-linked ubiquitination and degradation (By similarity). {ECO:0000255|HAMAP-Rule:MF_03034, ECO:0000269|PubMed:23063653, ECO:0000269|PubMed:8649414}.
uniprot
proteins
mass_dalton
38842
uniprot
proteins
protein_family
TARBP2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16142218
uniprot
proteins
pubmed
17452327
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23063653
uniprot
proteins
pubmed
8649414
uniprot
proteins
sequence_length
365
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03034, ECO:0000269|PubMed:8649414}. Cytoplasm, perinuclear region {ECO:0000255|HAMAP-Rule:MF_03034}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03034, ECO:0000269|PubMed:8649414}.
uniprot
proteins