Sun5
entrez
76407
canonical
uniprot
Q9DA32
canonical
ensembl
ENSMUSG00000027480
resolver
ensp
ENSMUSP00000028982
resolver
enst
ENSMUST00000028982
resolver
genesymbol
Sun5
resolver
genesymbol_syn
Spag4l
resolver
uniprot
A0A0R4J084
resolver
uniprot
D2DR64
resolver
uniprot
Q5DT38
resolver
uniprot_entry
A0A0R4J084_MOUSE
resolver
uniprot_entry
SUN5_MOUSE
resolver
uniprot_sec
D2DR64
resolver
uniprot_sec
Q5DT38
resolver
amino_acid_sequence
MPRTRNIGALCTLPEDTTHSGRPRRGVQRSYISRMAEPAPANMNDPLLLPLRMNTPGLSLVQILLGYMSWLTYLACFLRTQTQQVFLNTCRCKLFCQKVMEKMGLLVLCVFGFWMFSMHLPSKVEVWQDDSINGPLQSLRMYQEKVRHHTGEIQDLRGSMNQLIAKLQKMEAISDEQKMAQKIMKMIQGDYIEKPDFALKSIGASIDFEHTSATYNHDKARSYWNWIRLWNYAQPPDVILEPNVTPGNCWAFASDRGQVTIRLAQKVYLSNITLQHIPKTISLSGSPDTAPKDIVIYGLESLPREEVFLGAFQFQPENVIQMFQLQNLPPRSFAAVKVKISSNWGNPRFTCMYRVRVHGSVTPPKDSHLEPLS
uniprot
proteins
function
FUNCTION: Required for male fertility (PubMed:38870534). Plays an essential role in maintenance of sperm head-to-tail attachment during late stages of spermiogenesis, via promoting secure attachment of the nuclear envelope to the flagellum coupling apparatus (PubMed:28945193, PubMed:38870534). Component of the LMNB1/SUN5/SEPT12 bridge that connects the sperm proximal centriole to the implantation fossa, the bridge functions to prevent detachment of the proximal centriole from the posterior nucleus during in spermatids during spermiogenesis (PubMed:38870534). Required for localization of SEPT12 at the implantation fossa of sperm cells during spermiogenesis (PubMed:38870534). {ECO:0000269|PubMed:28945193, ECO:0000269|PubMed:38870534}.
uniprot
proteins
mass_dalton
42653
uniprot
proteins
mutagenesis
MUTAGEN 112; /note="G->R: Corresponds to R-114 variant associated with SPGF16 in human. Impairs nuclear inner membrane location, expressed in the cytosol with some protein aggregation near the nuclear envelope."; /evidence="ECO:0000269|PubMed:29298896"; MUTAGEN 160; /note="M->K: Corresponds to variant K-162 associated with SPGF16 in human. Increases interaction with DNAJB13. Impairs nuclear inner membrane location, expressed in the cytosol with some protein aggregation near the nuclear envelope."; /evidence="ECO:0000269|PubMed:29298896"; MUTAGEN 259; /note="V->M: Corresponds to M-261 variant associated with SPGF16 in human. Decreases protein solubility, impairs nuclear inner membrane location and decreases interaction with DNAJB13."; /evidence="ECO:0000269|PubMed:29298896"; MUTAGEN 273; /note="T->M: Corresponds to M-275 variant associated with SPGF16 in human. Impairs nuclear inner membrane location and decreases interaction with DNAJB13."; /evidence="ECO:0000269|PubMed:29298896"; MUTAGEN 346; /note="N->I: Corresponds to I-348 variant associated with SPGF16 in human. Impairs nuclear inner membrane location and increases interaction with DNAJB13."; /evidence="ECO:0000269|PubMed:29298896"; MUTAGEN 354; /note="R->C: Corresponds to C-356 variant associated with SPGF16 in human. Impairs nuclear inner membrane location and decreases interaction with DNAJB13."; /evidence="ECO:0000269|PubMed:29298896
uniprot
proteins
post_translational_modification
PTM: Highly glycosylated in the Golgi apparatus during spermiogenesis. {ECO:0000269|PubMed:25775128}.
uniprot
proteins
pubmed
15552040
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21159740
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21711156
uniprot
proteins
pubmed
25775128
uniprot
proteins
pubmed
28945193
uniprot
proteins
pubmed
29298896
uniprot
proteins
pubmed
38870534
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus inner membrane {ECO:0000269|PubMed:21159740, ECO:0000269|PubMed:25775128, ECO:0000269|PubMed:28945193, ECO:0000269|PubMed:29298896}; Single-pass membrane protein {ECO:0000269|PubMed:21159740}. Golgi apparatus {ECO:0000269|PubMed:25775128}. Note=During spermiogenesis, traffics through the Golgi apparatus before reaching the round spermatid inner membrane of the nuclear envelope and later migrates to the coupling apparatus of the sperm during sperm head elongation and differentiation (PubMed:21711156). Expressed at the sperm implantation fossa in spermatids from step 9 to 16 of spermiogenesis (PubMed:38870534). In mature spermatozoa, is localized to the coupling apparatus of the sperm head and tail in the implementation fossa. Expressed at the neck region in mature sperm (PubMed:38870534). {ECO:0000269|PubMed:21159740, ECO:0000269|PubMed:21711156, ECO:0000269|PubMed:25775128, ECO:0000269|PubMed:28945193, ECO:0000269|PubMed:38870534}.
uniprot
proteins
transmembrane_region
TRANSMEM 104..120; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins