Trim33
entrez
94093
canonical
uniprot
Q99PP7
canonical
ensembl
ENSMUSG00000033014
resolver
ensp
ENSMUSP00000029444
resolver
ensp
ENSMUSP00000102473
resolver
enst
ENSMUST00000029444
resolver
enst
ENSMUST00000106860
resolver
genesymbol
Trim33
resolver
genesymbol_syn
Kiaa1113
resolver
uniprot
E9QME5
resolver
uniprot
E9QP19
resolver
uniprot
Q6SI71
resolver
uniprot
Q6ZPX5
resolver
uniprot_entry
E9QME5_MOUSE
resolver
uniprot_entry
E9QP19_MOUSE
resolver
uniprot_entry
TRI33_MOUSE
resolver
uniprot_sec
Q6SI71
resolver
uniprot_sec
Q6ZPX5
resolver
amino_acid_sequence
MAENKGGGEAESGGGGSGSAPVTAGAAGPTAQEAEPPLAAVLVEEEEEEGGRAGAEGGAAGPDDGGVAAASSSSAPAASVPAASVGSAVPGGAASTPAPAAAPAPAPAPAPAPAPAPAPAPAPGSSSGPPLGPPASLLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDVQQVGVIRCPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKTCIEAHQRVKFTKDHLIRKKEDVSESVGTSGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQLLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQEIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAIASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIESKPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRLQQPPAPIPTTTATTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIPGIPRHSAPQYSMMQPHLQRQHSNPGHAGPFPVVSAHNPINPTSPTTATMANANRGPTSPSVTAIELIPSVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPSPGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKSAHSFKSDQVKVKQEPGTEEEICSFSGAVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDTLTGLENHVKTEPTDISESCKQSGLSNLVNGKSPIRNLMHRSARIGGDGNSKDDDPNEDWCAVCQNGGDLLCCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNMQHSKKGKTAQGLSPVDQRKCERLLLYLYCHELSIEFQEPVPVSIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQIPDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKGDSEVAKAGKAVALYFEDKLSEIYSDRTFTPLPEFEQDEDDGEVTEDSDEDFIQPRRKRLKSDERPVHIK
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway (By similarity). May act as a transcriptional repressor (By similarity). Inhibits the transcriptional response to TGF-beta/BMP signaling cascade (By similarity). Plays a role in the control of cell proliferation (By similarity). Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor. Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade) (By similarity). {ECO:0000250, ECO:0000269|PubMed:16751102}.
uniprot
proteins
mass_dalton
123843
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
post_translational_modification
PTM: Sumoylated with SUMO1. {ECO:0000269|PubMed:23213215}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
11331580
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15256250
uniprot
proteins
pubmed
15314655
uniprot
proteins
pubmed
16751102
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23213215
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
1142
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15314655, ECO:0000269|PubMed:16751102}. Note=In discrete nuclear dots resembling nuclear bodies (PubMed:15314655, PubMed:16751102). Localizes to sites of DNA damage (By similarity). {ECO:0000250|UniProtKB:Q9UPN9, ECO:0000269|PubMed:15314655, ECO:0000269|PubMed:16751102}.
uniprot
proteins