MTRF1
entrez
9617
canonical
uniprot
O75570
canonical
ensembl
ENSG00000120662
resolver
ensp
ENSP00000368793
resolver
ensp
ENSP00000567230
resolver
ensp
ENSP00000567244
resolver
ensp
ENSP00000567250
resolver
ensp
ENSP00000567251
resolver
ensp
ENSP00000567256
resolver
ensp
ENSP00000604086
resolver
ensp
ENSP00000604093
resolver
ensp
ENSP00000604095
resolver
ensp
ENSP00000618340
resolver
ensp
ENSP00000618344
resolver
ensp
ENSP00000618352
resolver
ensp
ENSP00000618355
resolver
ensp
ENSP00000796770
resolver
ensp
ENSP00000796771
resolver
genesymbol
MTRF1
resolver
hgnc
HGNC:7469
resolver
uniprot
B4DG01
resolver
uniprot
Q5T6Y5
resolver
uniprot
Q8IUQ6
resolver
uniprot_entry
RF1M_HUMAN
resolver
uniprot_sec
B4DG01
resolver
uniprot_sec
Q5T6Y5
resolver
uniprot_sec
Q8IUQ6
resolver
amino_acid_sequence
MNRHLCVWLFRHPSLNGYLQCHIQLHSHQFRQIHLDTRLQVFRQNRNCILHLLSKNWSRRYCHQDTKMLWKHKALQKYMENLSKEYQTLEQCLQHIPVNEENRRSLNRRHAELAPLAAIYQEIQETEQAIEELESMCKSLNKQDEKQLQELALEERQTIDQKINMLYNELFQSLVPKEKYDKNDVILEVTAGRTTGGDICQQFTREIFDMYQNYSCYKHWQFELLNYTPADYGGLHHAAARISGDGVYKHLKYEGGIHRVQRIPEVGLSSRMQRIHTGTMSVIVLPQPDEVDVKLDPKDLRIDTFRAKGAGGQHVNKTDSAVRLVHIPTGLVVECQQERSQIKNKEIAFRVLRARLYQQIIEKDKRQQQSARKLQVGTRAQSERIRTYNFTQDRVSDHRIAYEVRDIKEFLCGGKGLDQLIQRLLQSADEEAIAELLDEHLKSAK
uniprot
proteins
function
FUNCTION: Mitochondrial peptide chain release factor that directs the termination of translation in response to the peptide chain non-canonical stop codons AGG and AGA (PubMed:36302763, PubMed:36596788, PubMed:37141370). Non-canonical termination codons AGG and AGA are found at the end of MT-CO1/COX1 and MT-ND6/ND6 open reading frames, respectively (PubMed:37141370). Recognizes non-canonical stop codons via a network of interactions between the codon, MTRF1 and the ribosomal RNA (rRNA): in contrast to other translation release factors, which identify the codon in the A-site via direct interactions of amino acid side chains with the bases, MTRF1 repositions the first 2 bases of the stop codon to use an intricate network of interactions that includes residues of the release factor, the rRNA of the small ribosomal subunit, as well as neighboring bases of the mRNA (PubMed:37141370). {ECO:0000269|PubMed:36302763, ECO:0000269|PubMed:36596788, ECO:0000269|PubMed:37141370}.
uniprot
proteins
mass_dalton
52306
uniprot
proteins
mutagenesis
MUTAGEN 311..312; /note="GG->AA: Impaired mitochondrial peptide chain release factor activity."; /evidence="ECO:0000269|PubMed:36596788
uniprot
proteins
post_translational_modification
PTM: Methylation of glutamine in the GGQ triplet by HEMK1 is conserved from bacteria to mammals. {ECO:0000269|PubMed:35260756}.
uniprot
proteins
protein_family
Prokaryotic/mitochondrial release factor family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17803939
uniprot
proteins
pubmed
22569235
uniprot
proteins
pubmed
35260756
uniprot
proteins
pubmed
36302763
uniprot
proteins
pubmed
36596788
uniprot
proteins
pubmed
37141370
uniprot
proteins
pubmed
9838146
uniprot
proteins
sequence_length
445
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:17803939, ECO:0000269|PubMed:37141370}.
uniprot
proteins