Steap4
entrez
499991
canonical
uniprot
Q4V8K1
canonical
ensembl
ENSRNOG00000008602
resolver
ensembl
ENSRNOG00065018061
resolver
ensp
ENSRNOP00000011432
resolver
ensp
ENSRNOP00065024041
resolver
enst
ENSRNOT00000011432
resolver
enst
ENSRNOT00065030258
resolver
genesymbol
Steap4
resolver
uniprot_entry
STEA4_RAT
resolver
amino_acid_sequence
MEKTCADEFPLTVDSSEKQGVVCIFGTGDFGKSLGLKMLQCGYSVVFGSRNPQVSSLLPRGAEVLCYSEAASRSDVIVLAVHREHYDFLAELADSLKGRVLIDVSNNQKMNQYPESNAEYLAQLVPGAHVVKAFNTISAWALQSGTLDASRQVFVCGNDSKAKDRVMDIARTLGLTPLDQGSLVAAKEIENYPLQLFPMWRFPFYLSSGLCVFFFVYCAIREVIYPYVTGKTDSTYRLVVSIPNRVFPITALTLLALVYLPGILAAILQLYRGTKYRRFPNWLDHWMLCRKQLGLVALGFAFLHAIYTLVIPIRYYVRWRLRNATITQALTNKDSPFSSSTAWLSDSYLALGILGFFLFLLLGITSLPSVSNMVNWREFRFVQSKLGYLTLVLCTAHTLVYGGKRFLSPSILIWSLPSAYILALIIPCTVLVMKFILIMPCIDKTLTRIRQGWERKSKYAQSTLNGKSDI
uniprot
proteins
ec_number
1.16.1.-
uniprot
proteins
function
FUNCTION: Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (PubMed:23733181). Can also reduce Cu(2+) to Cu(1+) (PubMed:23733181). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance (By similarity). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (By similarity). Inhibits anchorage-independent cell proliferation (By similarity). {ECO:0000250|UniProtKB:Q687X5, ECO:0000250|UniProtKB:Q923B6, ECO:0000269|PubMed:23733181}.
uniprot
proteins
mass_dalton
52765
uniprot
proteins
mutagenesis
MUTAGEN 194; /note="L->A: No significant effect on enzyme activity or subcellular location."; /evidence="ECO:0000269|PubMed:23733181"; MUTAGEN 196; /note="L->A: No significant effect on enzyme activity or subcellular location."; /evidence="ECO:0000269|PubMed:23733181"; MUTAGEN 200; /note="W->A: No significant effect on enzyme activity or subcellular location."; /evidence="ECO:0000269|PubMed:23733181
uniprot
proteins
protein_family
STEAP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23733181
uniprot
proteins
sequence_length
470
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:23733181}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q687X5}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q687X5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q687X5}. Early endosome membrane {ECO:0000250|UniProtKB:Q687X5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q687X5}.
uniprot
proteins
transmembrane_region
TRANSMEM 202..224; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q687X5"; TRANSMEM 236..256; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q687X5"; TRANSMEM 293..313; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q687X5"; TRANSMEM 342..362; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q687X5"; TRANSMEM 381..401; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q687X5"; TRANSMEM 419..439; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q687X5
uniprot
proteins