Slc22a2
entrez
29503
canonical
uniprot
Q9R0W2
canonical
ensembl
ENSRNOG00000016625
resolver
ensp
ENSRNOP00000023116
resolver
enst
ENSRNOT00000023116
resolver
genesymbol
Slc22a2
resolver
genesymbol_syn
Oct2
resolver
uniprot
A0A0G2JSP9
resolver
uniprot
P70485
resolver
uniprot
P97558
resolver
uniprot_entry
A0A0G2JSP9_RAT
resolver
uniprot_entry
S22A2_RAT
resolver
uniprot_sec
P70485
resolver
uniprot_sec
P97558
resolver
activity_regulation
ACTIVITY REGULATION: Tyrosine phosphorylation of the transporter leads to activation of the transport activity. Inhibited by cGMP, most likely through a cGMP-binding protein that interacts with OCT2. {ECO:0000250|UniProtKB:O15244}.
uniprot
proteins
amino_acid_sequence
MSTVDDILEHIGEFHLFQKQTFFLLALLSGAFTPIYVGIVFLGFTPDHHCWSPGAAKLSQRCGWSQAEELNYTVPGLGPSDEASFLSQCMRYEVDWNQSTLDCVDPLSSLAADRNQLPLGPCEHGWVYNTPGSSIVTEFNLVCAHSWMLDLFQSVVNVGFFIGAMMIGYLADRFGRKFCLLVTILINAISGALMAISPNYAWMLVFRFLQGLVSKAGWLIGYILITEFVGLGYRRMVGICYQIAFTVGLLILAGVAYVIPNWRWLQFAVTLPNFCFLLYFWCIPESPRWLISQNKIVKAMKIIKHIAKKNGKSVPVSLQNLTPDEDAGKKLNPSFLDLVRTPQIRKHTLILMYNWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFIIILTIDRVGRRYPWAVSNMVAGAACLASVFIPDDLQWLKITIACLGRMGITMAYEMVCLVNAELYPTYIRNLGVLVCSSMCDIGGIITPFLVYRLTDIWMEFPLVVFAVVGLVAGALVLLLPETKGKALPETIEDAENMQRPRKKKEKRIYLQVKQADRPLS
uniprot
proteins
function
FUNCTION: Electrogenic voltage-dependent uniporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics (PubMed:10889205, PubMed:12538837, PubMed:15817714, PubMed:16581093, PubMed:9812985). Functions as a Na(+)-independent, bidirectional uniporter (By similarity). Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient (PubMed:10889205). However, may also engage electroneutral cation exchange when saturating concentrations of cation substrates are reached (PubMed:10889205). Predominantly expressed at the basolateral membrane of hepatocytes and proximal tubules and involved in the uptake and disposition of cationic compounds by hepatic and renal clearance from the blood flow (By similarity). Implicated in monoamine neurotransmitters uptake such as histamine, dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, serotonin and tyramine, thereby supporting a physiological role in the central nervous system by regulating interstitial concentrations of neurotransmitters (PubMed:16581093, PubMed:9812985). Also capable of transporting dopaminergic neuromodulators cyclo(his-pro), salsolinol and N-methyl-salsolinol, thereby involved in the maintenance of dopaminergic cell integrity in the central nervous system (By similarity). Mediates the bidirectional transport of acetylcholine (ACh) at the apical membrane of ciliated cell in airway epithelium, thereby playing a role in luminal release of ACh from bronchial epithelium (PubMed:15817714). Also transports guanidine and endogenous monoamines such as vitamin B1/thiamine, creatinine and N-1-methylnicotinamide (NMN) (PubMed:11758759). Mediates the uptake and efflux of choline (PubMed:10889205). Mediates the bidirectional transport of polyamine agmatine and the uptake of polyamine putrescine (PubMed:12538837). Able to transport non-amine endogenous compounds such as prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) (By similarity). Also involved in the uptake of xenobiotic 4-(4-(dimethylamino)styryl)-N-methylpyridinium (ASP) (By similarity). May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (By similarity). {ECO:0000250|UniProtKB:O15244, ECO:0000269|PubMed:10889205, ECO:0000269|PubMed:11758759, ECO:0000269|PubMed:12538837, ECO:0000269|PubMed:15817714, ECO:0000269|PubMed:16581093, ECO:0000269|PubMed:9812985}.
uniprot
proteins
mass_dalton
62343
uniprot
proteins
mutagenesis
MUTAGEN 451; /note="C->M: Transport activity strongly reduced."; /evidence="ECO:0000269|PubMed:17567940
uniprot
proteins
post_translational_modification
PTM: Tyrosine phosphorylated. {ECO:0000250|UniProtKB:O15244}.
uniprot
proteins
protein_family
Major facilitator (TC 2.A.1) superfamily
uniprot
proteins
protein_family
Organic cation transporter (TC 2.A.1.19) family
uniprot
proteins
pubmed
10385678
uniprot
proteins
pubmed
10812069
uniprot
proteins
pubmed
10889205
uniprot
proteins
pubmed
11083459
uniprot
proteins
pubmed
11758759
uniprot
proteins
pubmed
12538837
uniprot
proteins
pubmed
15817714
uniprot
proteins
pubmed
16006492
uniprot
proteins
pubmed
16242669
uniprot
proteins
pubmed
16272756
uniprot
proteins
pubmed
16581093
uniprot
proteins
pubmed
17567940
uniprot
proteins
pubmed
17582384
uniprot
proteins
pubmed
18180268
uniprot
proteins
pubmed
8702418
uniprot
proteins
pubmed
9260930
uniprot
proteins
pubmed
9812985
uniprot
proteins
pubmed
9830022
uniprot
proteins
sequence_length
555
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000269|PubMed:11083459}; Multi-pass membrane protein {ECO:0000305}. Basal cell membrane {ECO:0000250|UniProtKB:O15244}; Multi-pass membrane protein {ECO:0000250|UniProtKB:O15244}. Apical cell membrane {ECO:0000269|PubMed:15817714}; Multi-pass membrane protein {ECO:0000305}. Note=Localized to the basolateral membranes of renal proximal tubular cells (PubMed:11083459). Localized to the luminal/apical membrane of ciliated epithelial cells in the airway (PubMed:15817714). {ECO:0000269|PubMed:11083459, ECO:0000269|PubMed:15817714}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 151..171; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 178..198; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 211..231; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 239..259; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 264..284; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 349..369; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 376..396; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 405..425; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 433..453; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 465..485; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 495..515; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins