Coq7
entrez
12850
canonical
uniprot
P97478
canonical
ensembl
ENSMUSG00000030652
resolver
ensp
ENSMUSP00000032887
resolver
ensp
ENSMUSP00000095695
resolver
ensp
ENSMUSP00000146797
resolver
enst
ENSMUST00000032887
resolver
enst
ENSMUST00000098090
resolver
enst
ENSMUST00000209146
resolver
genesymbol
Coq7
resolver
genesymbol_syn
COQ7
resolver
uniprot
A0A140LIF0
resolver
uniprot
F6WVM5
resolver
uniprot
Q3TYT1
resolver
uniprot
Q9R0D7
resolver
uniprot_entry
A0A140LIF0_MOUSE
resolver
uniprot_entry
COQ7_MOUSE
resolver
uniprot_entry
F6WVM5_MOUSE
resolver
uniprot_entry
Q3TYT1_MOUSE
resolver
uniprot_sec
Q9R0D7
resolver
amino_acid_sequence
MSAAGAIAAASVGRLRTGVRRPFSEYGRGLIIRCHSSGMTLDNINRAAVDRIIRVDHAGEYGANRIYAGQMAVLGRTSVGPVIQKMWDQEKNHLKKFNELMIAFRVRPTVLMPLWNVAGFALGAGTALLGKEGAMACTVAVEESIANHYNNQIRMLMEEDPEKYEELLQVIKQFRDEELEHHDTGLDHDAELAPAYALLKRIIQAGCSAAIYLSERF
uniprot
proteins
ec_number
1.14.13.253
uniprot
proteins
function
FUNCTION: Catalyzes the hydroxylation of the 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzoquinone at the C6 position and participates in the biosynthesis of ubiquinone. Catalyzes the reaction through a substrate-mediated reduction pathway, whereby NADH shuttles electrons to 5-methoxy-2-methyl-3-(all-trans-decaprenyl)benzoquinone, which then transfers the electrons to the two Fe(3+) centers. The binding of 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzoquinone (DMQn) mediates reduction of the diiron center by nicotinamide adenine dinucleotide (NADH) and initiates oxygen activation for subsequent DMQ hydroxylation. The physiological substrates are 5-methoxy-2-methyl-3-(all-trans-nonaprenyl)benzoquinone (DMQ(9)) and 5-methoxy-2-methyl-3-(all-trans-decaprenyl)benzoquinone (DMQ(10)), however in vitro the enzyme does not have any specificity concerning the length of the polyprenyl tail, and accepts tails of various lengths with similar efficiency (By similarity). Also has a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides (By similarity). Involved in lifespan determination in a ubiquinone-independent manner (PubMed:19478076). Plays a role in modulating mitochondrial stress responses, acting in the nucleus, perhaps via regulating gene expression, independent of its characterized mitochondrial function in ubiquinone biosynthesis (By similarity). {ECO:0000250|UniProtKB:Q99807, ECO:0000255|HAMAP-Rule:MF_03194, ECO:0000269|PubMed:19478076}.
uniprot
proteins
mass_dalton
24042
uniprot
proteins
mutagenesis
MUTAGEN 178; /note="E->K: No detectable ubiquinone is produced."; /evidence="ECO:0000269|PubMed:28409910
uniprot
proteins
pathway_participation
PATHWAY: Cofactor biosynthesis; ubiquinone biosynthesis. {ECO:0000269|PubMed:20923139}.
uniprot
proteins
protein_family
COQ7 family
uniprot
proteins
pubmed
10373327
uniprot
proteins
pubmed
10501970
uniprot
proteins
pubmed
11387338
uniprot
proteins
pubmed
11511092
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19478076
uniprot
proteins
pubmed
20923139
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
28409910
uniprot
proteins
pubmed
9020081
uniprot
proteins
sequence_length
217
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000255|HAMAP-Rule:MF_03194, ECO:0000269|PubMed:11387338, ECO:0000269|PubMed:11511092}; Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_03194, ECO:0000269|PubMed:11387338}; Matrix side {ECO:0000255|HAMAP-Rule:MF_03194, ECO:0000269|PubMed:11387338}.
uniprot
proteins