Pip4k2b
entrez
108083
canonical
uniprot
Q80XI4
canonical
ensembl
ENSMUSG00000018547
resolver
ensp
ENSMUSP00000018691
resolver
enst
ENSMUST00000018691
resolver
genesymbol
Pip4k2b
resolver
genesymbol_syn
Pip5k2b
resolver
uniprot
Q3UJ95
resolver
uniprot
Q8VHB2
resolver
uniprot_entry
PI42B_MOUSE
resolver
uniprot_entry
Q3UJ95_MOUSE
resolver
uniprot_sec
Q8VHB2
resolver
amino_acid_sequence
MSSNCTSTTAVAVAPLSASKTKTKKKHFVCQKVKLFRASEPILSVLMWGVNHTINELSNVPVPVMLMPDDFKAYSKIKVDNHLFNKENLPSRFKFKEYCPMVFRNLRERFGIDDQDYQNSVTRSAPINSDSQGRCGTRFLTTYDRRFVIKTVSSEDVAEMHNILKKYHQFIVECHGNTLLPQFLGMYRLTVDGVETYMVVTRNVFSHRLTVHRKYDLKGSTVAREASDKEKAKDLPTFKDNDFLNEGQKLHVGEESKKNFLEKLKRDVEFLAQLKIMDYSLLVGIHDVDRAEQEEMEVEERAEEEECENDGVGGSLLCSYGTPPDSPGNLLSFPRFFGPGEFDPSVDVYAMKSHESAPKKEVYFMAIIDILTPYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFNEFMSNILT
uniprot
proteins
ec_number
2.7.1.149
uniprot
proteins
function
FUNCTION: Participates in the biosynthesis of phosphatidylinositol 4,5-bisphosphate. Preferentially utilizes GTP, rather than ATP, for PI(5)P phosphorylation and its activity reflects changes in direct proportion to the physiological GTP concentration. Its GTP-sensing activity is critical for metabolic adaptation. In collaboration with PIP4K2A, has a role in mediating autophagy in times of nutrient stress (PubMed:29727621). Required for autophagosome-lysosome fusion and the regulation of cellular lipid metabolism (PubMed:29727621). PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (By similarity). {ECO:0000250|UniProtKB:P78356, ECO:0000269|PubMed:29727621}.
uniprot
proteins
mass_dalton
47319
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the SPOP/CUL3 complex. Ubiquitination is stimulated by PtdIns5P levels. {ECO:0000250|UniProtKB:P78356}.; PTM: Phosphorylated on serine residues. {ECO:0000250|UniProtKB:P78356}.
uniprot
proteins
pubmed
12438746
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
29727621
uniprot
proteins
sequence_length
416
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Note=Associated with the plasma membrane and the endoplasmic reticulum. {ECO:0000250}.
uniprot
proteins