Shc1
entrez
85385
canonical
uniprot
Q5M824
canonical
ensembl
ENSRNOG00000020657
resolver
ensp
ENSRNOP00000028038
resolver
ensp
ENSRNOP00000053490
resolver
enst
ENSRNOT00000028038
resolver
genesymbol
Shc1
resolver
uniprot
G3V8S2
resolver
uniprot_entry
G3V8S2_RAT
resolver
uniprot_entry
SHC1_RAT
resolver
amino_acid_sequence
MNKLSGGGGRRTRVEGGQLGGEEWTRHGSFVNKPTRGWLHPNDKVMGPGVSYLVRYMGCVEVLQSMRALDFNTRTQVTREAISLVCEAVPGAKGAMRRRKPCSRPLSSILGRSNLKFAGMPITLTVSTSSLNLMAADCKQIIANHHMQSISFASGGDPDTAEYVAYVAKDPVNQRACHILECPEGLAQDVISTIGQAFELRFKQYLRNPPKLVTPHDRMAGFDGSAWDEEEEELPDHQYYNDFPGKEPPLGGVVDMRLREGAARPTLPSTQMPSHLGATLPIGQHVTGDHEVRKQMLPPPPCPGRELFDDPSYVNIQNLDKARQAGGGAGPPNPSVNGSAPRDLFDMKPFEDALRVPPAPQSMSMAEQLQGESWFHGKLSRREAEALLQLNGDFLVRESTTTPGQYVLTGLQSGQPKHLLLVDPEGVVRTKDHRFESVSHLISYHMDNHLPIISAGSELCLQQPVDRKV
uniprot
proteins
function
FUNCTION: Signaling adapter that couples activated growth factor receptors to signaling pathways. Participates in a signaling cascade initiated by activated KIT and KITLG/SCF. Isoform p46Shc and isoform p52Shc, once phosphorylated, couple activated receptor tyrosine kinases to Ras via the recruitment of the GRB2/SOS complex and are implicated in the cytoplasmic propagation of mitogenic signals. Isoform p46Shc and isoform p52Shc may thus function as initiators of the Ras signaling cascade in various non-neuronal systems. Isoform p66Shc does not mediate Ras activation, but is involved in signal transduction pathways that regulate the cellular response to oxidative stress and life span. Isoform p66Shc acts as a downstream target of the tumor suppressor p53 and is indispensable for the ability of stress-activated p53 to induce elevation of intracellular oxidants, cytochrome c release and apoptosis. The expression of isoform p66Shc has been correlated with life span (By similarity). Participates in signaling downstream of the angiopoietin receptor TEK/TIE2, and plays a role in the regulation of endothelial cell migration and sprouting angiogenesis (By similarity). Involved in the oncostatin-M-mediated signaling pathway through type II OSM receptor complex (heterodimers composed of OSMR and IL6ST) where it contributes to activation of the Ras/Raf/MAPK pathway through JAK1-dependent recruitment to OSMR subunit of OSMR complex and SHC1 association with GRB2 (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P29353}.
uniprot
proteins
mass_dalton
51503
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by activated epidermal growth factor receptor. Phosphorylated in response to KIT signaling. Tyrosine phosphorylated in response to FLT3 signaling and by ligand-activated ALK. Tyrosine phosphorylated by TEK/TIE2 (By similarity). Tyrosine phosphorylated by ligand-activated PDGFRB (By similarity). May be tyrosine phosphorylated by activated PTK2/FAK1 (By similarity). Dephosphorylation by PTPN2 may regulate interaction with GRB2 (By similarity). Phosphorylated in response to FLT4 signaling. Tyrosine phosphorylated by activated PTK2B/PYK2. Oncostatin-M-mediated signaling pathway induces phosphorylation at tyrosine residues by JAK1 leading to its activation and allows, concomitantly, SHC1 recruitment to OSMR subunit of OSMR complex and SHC1 association with GRB2 (By similarity). {ECO:0000250, ECO:0000250|UniProtKB:P29353, ECO:0000269|PubMed:7544443, ECO:0000269|PubMed:7675451}.
uniprot
proteins
pubmed
11694516
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16186108
uniprot
proteins
pubmed
7544443
uniprot
proteins
pubmed
7675451
uniprot
proteins
pubmed
9582017
uniprot
proteins
sequence_length
469
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P29353}.
uniprot
proteins