Rho
entrez
24717
canonical
uniprot
P51489
canonical
ensembl
ENSRNOG00000011144
resolver
ensp
ENSRNOP00000061473
resolver
enst
ENSRNOT00000064603
resolver
genesymbol
Rho
resolver
uniprot
A0A0G2JSY7
resolver
uniprot_entry
A0A0G2JSY7_RAT
resolver
uniprot_entry
OPSD_RAT
resolver
amino_acid_sequence
MNGTEGPNFYVPFSNITGVVRSPFEQPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADLFMVFGGFTTTLYTSLHGYFVFGPTGCNLEGFFATLGGEIGLWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLVGWSRYIPEGMQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIVIFFCYGQLVFTVKEAAAQQQESATTQKAEKEVTRMVIIMVIFFLICWLPYASVAMYIFTHQGSNFGPIFMTLPAFFAKTASIYNPIIYIMMNKQFRNCMLTSLCCGKNPLGDDEASATASKTETSQVAPA
uniprot
proteins
function
FUNCTION: G protein-coupled photoreceptor that activates the G protein transducin (t) signaling pathway in response to light and is essential for image-forming vision under low-light conditions. Required for postnatal photoreceptor cell viability. Activation occurs when the covalently bound 11-cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers G protein-mediated phototransduction. Signal termination occurs via receptor phosphorylation, which promotes binding of arrestin (SAG) and displacement of the G protein alpha subunit. {ECO:0000250|UniProtKB:P08100}.
uniprot
proteins
mass_dalton
39042
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region (By similarity). {ECO:0000250|UniProtKB:P02699}.; PTM: Contains one covalently linked retinal chromophore. Upon light absorption, the covalently bound 11-cis-retinal is converted to all-trans-retinal. Following activation, the covalently bound all-trans-retinal is released through hydrolysis of the Schiff base, and rhodopsin is regenerated by binding a new 11-cis-retinal molecule. {ECO:0000250|UniProtKB:P08100}.
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Opsin subfamily
uniprot
proteins
pubmed
7654522
uniprot
proteins
sequence_length
348
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Photoreceptor outer segment membrane {ECO:0000250|UniProtKB:P08100}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P08100}. Membrane {ECO:0000250|UniProtKB:P08100}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P08100}. Note=Synthesized in the inner segment (IS) of rod photoreceptor cells before vectorial transport to disk membranes in the rod outer segment (OS) photosensory cilia. {ECO:0000250|UniProtKB:P08100}.
uniprot
proteins
transmembrane_region
TRANSMEM 37..61; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P02699"; TRANSMEM 74..96; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P02699"; TRANSMEM 111..133; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P02699"; TRANSMEM 153..173; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P02699"; TRANSMEM 203..224; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P02699"; TRANSMEM 253..274; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P02699"; TRANSMEM 287..308; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P02699
uniprot
proteins