HCAR1
entrez
27198
canonical
uniprot
Q9BXC0
canonical
ensembl
ENSG00000196917
resolver
ensp
ENSP00000389255
resolver
enst
ENST00000432564
resolver
genesymbol
HCAR1
resolver
genesymbol_syn
GPR104
resolver
genesymbol_syn
GPR81
resolver
genesymbol_syn
HCA1
resolver
hgnc
HGNC:4532
resolver
uniprot
B2R9X4
resolver
uniprot
Q3Y5J3
resolver
uniprot
Q4VBN1
resolver
uniprot
Q6NXU5
resolver
uniprot_entry
HCAR1_HUMAN
resolver
uniprot_sec
B2R9X4
resolver
uniprot_sec
Q3Y5J3
resolver
uniprot_sec
Q4VBN1
resolver
uniprot_sec
Q6NXU5
resolver
amino_acid_sequence
MYNGSCCRIEGDTISQVMPPLLIVAFVLGALGNGVALCGFCFHMKTWKPSTVYLFNLAVADFLLMICLPFRTDYYLRRRHWAFGDIPCRVGLFTLAMNRAGSIVFLTVVAADRYFKVVHPHHAVNTISTRVAAGIVCTLWALVILGTVYLLLENHLCVQETAVSCESFIMESANGWHDIMFQLEFFMPLGIILFCSFKIVWSLRRRQQLARQARMKKATRFIMVVAIVFITCYLPSVSARLYFLWTVPSSACDPSVHGALHITLSFTYMNSMLDPLVYYFSSPSFPKFYNKLKICSLKPKQPGHSKTQRPEEMPISNLGRRSCISVANSFQSQSDGQWDPHIVEWH
uniprot
proteins
function
FUNCTION: Acts as a receptor for L-lactate and mediates its anti-lipolytic effect through a G(i)-protein-mediated pathway. {ECO:0000269|PubMed:19047060}.
uniprot
proteins
mass_dalton
39295
uniprot
proteins
mutagenesis
MUTAGEN 71; /note="R->A: Greatly impairs the agonistic activity of CHBA."; /evidence="ECO:0000269|PubMed:40233099"; MUTAGEN 99; /note="R->A: Diminishes the response to L-lactate. Abolishes the agonistic activity of CHBA."; /evidence="ECO:0000269|PubMed:19047060, ECO:0000269|PubMed:40233099"; MUTAGEN 166; /note="E->A: Greatly impairs the agonistic activity of CHBA."; /evidence="ECO:0000269|PubMed:40233099"; MUTAGEN 168; /note="F->A: Reduction in agonistic activity of CHBA."; /evidence="ECO:0000269|PubMed:40233099"; MUTAGEN 233; /note="Y->A: Diminishes the response to L-lactate."; /evidence="ECO:0000269|PubMed:19047060"; MUTAGEN 240; /note="R->A: Diminishes the response to L-lactate."; /evidence="ECO:0000269|PubMed:19047060"; MUTAGEN 261; /note="H->A: Greatly impairs the agonistic activity of CHBA."; /evidence="ECO:0000269|PubMed:40233099"; MUTAGEN 264; /note="L->A: Reduction in agonistic activity of CHBA."; /evidence="ECO:0000269|PubMed:40233099"; MUTAGEN 267; /note="T->A: Diminishes the response to L-lactate."; /evidence="ECO:0000269|PubMed:19047060
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
11574155
uniprot
proteins
pubmed
12044878
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
19047060
uniprot
proteins
pubmed
21454438
uniprot
proteins
pubmed
40233099
uniprot
proteins
sequence_length
346
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19047060}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 50..70; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 90..110; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 131..151; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 183..203; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 221..241; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 262..281; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins