RNF19A
entrez
25897
canonical
uniprot
Q9NV58
canonical
ensembl
ENSG00000034677
resolver
ensp
ENSP00000342667
resolver
ensp
ENSP00000428968
resolver
ensp
ENSP00000575760
resolver
ensp
ENSP00000575763
resolver
genesymbol
RNF19A
resolver
genesymbol_syn
RNF19
resolver
hgnc
HGNC:13432
resolver
uniprot
A3KCU9
resolver
uniprot
Q52LG1
resolver
uniprot
Q9H5H9
resolver
uniprot
Q9H8M8
resolver
uniprot
Q9UFG0
resolver
uniprot
Q9UFX6
resolver
uniprot
Q9Y4Y1
resolver
uniprot_entry
RN19A_HUMAN
resolver
uniprot_sec
A3KCU9
resolver
uniprot_sec
Q52LG1
resolver
uniprot_sec
Q9H5H9
resolver
uniprot_sec
Q9H8M8
resolver
uniprot_sec
Q9UFG0
resolver
uniprot_sec
Q9UFX6
resolver
uniprot_sec
Q9Y4Y1
resolver
amino_acid_sequence
MQEQEIGFISKYNEGLCVNTDPVSILTSILDMSLHRQMGSDRDLQSSASSVSLPSVKKAPKKRRISIGSLFRRKKDNKRKSRELNGGVDGIASIESIHSEMCTDKNSIFSTNTSSDNGLTSISKQIGDFIECPLCLLRHSKDRFPDIMTCHHRSCVDCLRQYLRIEISESRVNISCPECTERFNPHDIRLILSDDVLMEKYEEFMLRRWLVADPDCRWCPAPDCGYAVIAFGCASCPKLTCGREGCGTEFCYHCKQIWHPNQTCDAARQERAQSLRLRTIRSSSISYSQESGAAADDIKPCPRCAAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLVGAPVGIALIAGIAIPAMIIGIPVYVGRKIHNRYEGKDVSKHKRNLAIAGGVTLSVIVSPVVAAVTVGIGVPIMLAYVYGVVPISLCRSGGCGVSAGNGKGVRIEFDDENDINVGGTNTAVDTTSVAEARHNPSIGEGSVGGLTGSLSASGSHMDRIGAIRDNLSETASTMALAGASITGSLSGSAMVNCFNRLEVQADVQKERYSLSGESGTVSLGTVSDNASTKAMAGSILNSYIPLDKEGNSMEVQVDIESKPSKFRHNSGSSSVDDGSATRSHAGGSSSGLPEGKSSATKWSKEATAGKKSKSGKLRKKGNMKINETREDMDAQLLEQQSTNSSEFEAPSLSDSMPSVADSHSSHFSEFSCSDLESMKTSCSHGSSDYHTRFATVNILPEVENDRLENSPHQCSISVVTQTASCSEVSQLNHIAEEHGNNGIKPNVDLYFGDALKETNNNHSHQTMELKVAIQTEI
uniprot
proteins
ec_number
2.3.2.31
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Specifically ubiquitinates pathogenic SOD1 variants, which leads to their proteasomal degradation and to neuronal protection. {ECO:0000269|PubMed:11237715, ECO:0000269|PubMed:12145308, ECO:0000269|PubMed:12750386, ECO:0000269|PubMed:15456787, ECO:0000269|PubMed:16513638}.
uniprot
proteins
mass_dalton
90696
uniprot
proteins
mutagenesis
MUTAGEN 132; /note="C->S: Abolishes interaction with VCP and E3 ligase activity toward mutant SOD1; when associated with S-135."; /evidence="ECO:0000269|PubMed:15456787"; MUTAGEN 135; /note="C->S: Abolishes interaction with VCP and E3 ligase activity toward mutant SOD1; when associated with S-132."; /evidence="ECO:0000269|PubMed:15456787
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
RBR family
uniprot
proteins
protein_family
RNF19 subfamily
uniprot
proteins
pubmed
10976766
uniprot
proteins
pubmed
11237715
uniprot
proteins
pubmed
12145308
uniprot
proteins
pubmed
12750386
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15456787
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16513638
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
24275569
uniprot
proteins
sequence_length
838
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:11237715, ECO:0000269|PubMed:12145308, ECO:0000269|PubMed:12750386, ECO:0000269|PubMed:15456787}. Note=Present in the hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients.
uniprot
proteins
transmembrane_region
TRANSMEM 368..388; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 424..444; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins