Emc9
entrez
290224
canonical
uniprot
Q5U1W7
canonical
ensembl
ENSRNOG00000019162
resolver
ensembl
ENSRNOG00055012556
resolver
ensembl
ENSRNOG00060022568
resolver
ensembl
ENSRNOG00065033237
resolver
ensp
ENSRNOP00000026001
resolver
ensp
ENSRNOP00055017326
resolver
ensp
ENSRNOP00060032370
resolver
ensp
ENSRNOP00065047032
resolver
enst
ENSRNOT00055021411
resolver
enst
ENSRNOT00060039150
resolver
enst
ENSRNOT00065057138
resolver
genesymbol
Emc9
resolver
genesymbol_syn
Fam158a
resolver
uniprot_entry
EMC9_RAT
resolver
amino_acid_sequence
MGEVEISARAYGKMCLHASRYPHAAVNGLLLAPATRSGECLCLTDCVPLFHSHLALSVMLEVALNQVDVWATQAGLVVAGYYHANAVLDDQSPGPLALKIAGRIAEFFPNAVLIMLDNKKLVTWPRVPPVIVLENQGLQWVPKDKNLVMWRDWEESRQMVGALLEGRAHQHLVDFDCHLDDIRQDWTNQRLNTQITQWSGSTDGHA
uniprot
proteins
function
FUNCTION: Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. {ECO:0000250|UniProtKB:Q9Y3B6}.
uniprot
proteins
mass_dalton
22941
uniprot
proteins
protein_family
EMC8/EMC9 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
206
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Y3B6}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9Y3B6}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Y3B6}.
uniprot
proteins