Entrep1
entrez
381217
canonical
uniprot
Q4FZH1
canonical
ensembl
ENSMUSG00000071604
resolver
ensp
ENSMUSP00000093878
resolver
ensp
ENSMUSP00000313072
resolver
genesymbol
Entrep1
resolver
genesymbol_syn
Fam189a2
resolver
genesymbol_syn
Gm967
resolver
uniprot
E9QP68
resolver
uniprot_entry
EREP1_MOUSE
resolver
uniprot_sec
E9QP68
resolver
amino_acid_sequence
MILLVNLFVLLSVVCILLNLAGFILGCQGAQFVSSVPRCDLVDLGEGKICFCCEEFQPAKCTDKENALKLFPVQPCSAVHLLLKKVLFALCALNALTTTVCLVAAALRYLQIFASRRPCIDESQMSAEDVEEHGRIPDPDDFVPPVPPPSYFATFYSCTPRMNRRMVGSDVIPLPHIYGARIKGVEVFCPLDPPPPYEAVVSQTDQEQESSFQMPEGPETAASPAEPVCTQITQGGALTNTTGEENTSGSTPILTLVQPPRSRRALPLLRTRSKSDPVLHHSEERATPVLSCEAATQTERRLDLATVTLRRGARPRASRCRPRSLIDYRSYIDTKLLVARFLEQSSCSMTPDIHELVENIKSVLKSDEGHMEEAITSASFLEQIMAPSQPSTSQAQELSWRRQPGLLHLRSCGDLSTFSLTARPRAERRPQQRAEAERPHSLIGVIRETVL
uniprot
proteins
function
FUNCTION: Functions as an activator of the E3 ubiquitin protein ligase ITCH in the ubiquitination of the CXCL12-activated CXCR4 receptor. Thereby, triggers CXCR4 endocytosis and desensitization, negatively regulating the CXCL12/CXCR4 signaling pathway. {ECO:0000250|UniProtKB:Q15884}.
uniprot
proteins
mass_dalton
49804
uniprot
proteins
protein_family
ENTREP family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
451
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000250|UniProtKB:Q15884}; Single-pass type I membrane protein {ECO:0000255}. Late endosome membrane {ECO:0000250|UniProtKB:Q15884}; Single-pass type I membrane protein {ECO:0000255}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q15884}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q15884}; Single-pass type I membrane protein {ECO:0000255}. Note=Enriched in endosomes compared to the cell membrane. {ECO:0000250|UniProtKB:Q15884}.
uniprot
proteins
transmembrane_region
TRANSMEM 86..106; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins