Ppip5k1
entrez
327655
canonical
uniprot
A2ARP1
canonical
ensembl
ENSMUSG00000033526
resolver
ensp
ENSMUSP00000106255
resolver
ensp
ENSMUSP00000106256
resolver
ensp
ENSMUSP00000324918
resolver
ensp
ENSMUSP00000324920
resolver
ensp
ENSMUSP00000324921
resolver
ensp
ENSMUSP00000324923
resolver
ensp
ENSMUSP00000324926
resolver
ensp
ENSMUSP00000324928
resolver
ensp
ENSMUSP00000324929
resolver
ensp
ENSMUSP00000324932
resolver
ensp
ENSMUSP00000324938
resolver
ensp
ENSMUSP00000324940
resolver
ensp
ENSMUSP00000324944
resolver
ensp
ENSMUSP00000324952
resolver
ensp
ENSMUSP00000324957
resolver
genesymbol
Ppip5k1
resolver
genesymbol_syn
Hisppd2a
resolver
genesymbol_syn
Kiaa0377
resolver
genesymbol_syn
Vip1
resolver
uniprot
A2ARP2
resolver
uniprot
A2ARP3
resolver
uniprot
A2ARP4
resolver
uniprot
Q6P1C8
resolver
uniprot
Q7TSP1
resolver
uniprot
Q80U21
resolver
uniprot
Q8BL16
resolver
uniprot
Q8BUN6
resolver
uniprot
Q8BVG9
resolver
uniprot_entry
VIP1_MOUSE
resolver
uniprot_sec
A2ARP2
resolver
uniprot_sec
A2ARP3
resolver
uniprot_sec
A2ARP4
resolver
uniprot_sec
Q6P1C8
resolver
uniprot_sec
Q7TSP1
resolver
uniprot_sec
Q80U21
resolver
uniprot_sec
Q8BL16
resolver
uniprot_sec
Q8BUN6
resolver
uniprot_sec
Q8BVG9
resolver
amino_acid_sequence
MWSLTANEDESTTAHFFLGAGDEGLGTCGIGMRTEESDSELLEDEEDEVPPEPQIIVGICAMTKKSKSKPMTQILERLCRFDYLTVVILGEDVILNEPVENWPSCHCLISFHSKGFPLDKAVAYSKLRNPFLINDLAMQYYIQDRREVYRILQEEGIDLPRYAVLNRDPACPEECSLIEGEDQVEVNGAVFPKPFVEKPVSAEDHNVYIYYPSSAGGGSQRLFRKIGSRSSVYSPESSVRKTGSYIYEEFMPTDGTDVKVYTVGPDYAHAEARKSPALDGKVERDSEGKEVRYPVMLTAMEKLVARKVCVAFKQTVCGFDLLRANGHSFVCDVNGFSFVKNSMKYYDDCAKILGNTIMRELAPQFQIPWSIPTEAEDIPIVPTTSGTMMELRCVIAIIRHGDRTPKQKMKMEVTHPRFFALFEKHGGYKTGKLKLKRPEQLQEVLDITRLLLAELEKEPEAEIEEKTGKLEQLKSVLEMYGHFSGINRKVQLTYYPHGVKASNEGQDLQREPLAPSLLLVLKWGGELTPDGRVQAEELGRAFRCMYPGGQGDYAGFPGCGLLRLHSTFRHDLKIYASDEGRVQMTAAAFAKGLLALEGELTPILVQMVKSANMNGLLDSDSDSLSSCQHRVKARLHHILQQDAPFGPEDYDQLAPTGSTSLLNSMSVIQNPVKVCDQVFALIENLTHQIRERMQDPSSVDLQLYHSETLELMLQRWSKLERDFRQKSGRYDISKIPDIYDCVKYDVQHNGSLGLQGTAELLRLSKALADVVIPQEYGISREEKVEIAVGFCLPLLRKILLDLQRTHEDESVNKLHPLYSRGVLSPGRHVRTRLYFTSESHVHSLLSVFRYGGLLDETQDAQWQRALAYLSAISELNYMTQIVIMLYEDNTRDPLSEERFHVELHFSPGVKGVEEGSAPAGCGFRPASSENEEMKTDPGSIENLCPGKASDEPDRALQTSPQPVEGTGLPRRSPLIRNRKAGSMEVLSETSSSRPGGYRLFSSSRPPTEMKQSGLGSQCTGLFSTTVLGGSSSAPNLQDYARTHGKKLPPASLKHRDELLFVPAVKRFSVSFAKHPTNGFEGCSMVPTIYPLETLHNALSLRQVSEFLTKVCQRHTDAHAQASAALFDSMHNHQASDSPFSPPRTLHSPPLQLRHRSEKPPWYSSGPSSTVSSAGPSSPTTVDGNSHFGFSDQSSVNIHMTEEKQGFGLLQETPGDGTRELHIERQQELVEPAQSPQELPVEICPSGSQGVTKVSQTCQEVPDIVQPCHNIHEEIGQPQQEVPDISQLLLKDHDTTTNTCHLCQASQLSQKVCEEICQLCQDNHEESNQLCQEVSVKLGRMVHGFPVNVDSTAQETLMEIGRPTQEIPEDPYQEFSVKVGVLAQKAPAISELSQDIPEADKPSQELSEETELQAQEVSEEIDQESEVVDELPPEAIS
uniprot
proteins
ec_number
2.7.4.24
uniprot
proteins
function
FUNCTION: Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress. {ECO:0000250|UniProtKB:Q6PFW1}.
uniprot
proteins
mass_dalton
159923
uniprot
proteins
protein_family
Histidine acid phosphatase family
uniprot
proteins
protein_family
VIP1 subfamily
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
1436
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q6PFW1}. Cell membrane {ECO:0000250|UniProtKB:Q6PFW1}. Note=Relocalizes to the plasma membrane upon activation of the PtdIns 3-kinase pathway. {ECO:0000250|UniProtKB:Q6PFW1}.
uniprot
proteins