IL33
entrez
90865
canonical
uniprot
O95760
canonical
ensembl
ENSG00000137033
resolver
ensp
ENSP00000394039
resolver
ensp
ENSP00000414238
resolver
ensp
ENSP00000507310
resolver
ensp
ENSP00000563998
resolver
ensp
ENSP00000564001
resolver
ensp
ENSP00000564002
resolver
ensp
ENSP00000564004
resolver
ensp
ENSP00000564012
resolver
ensp
ENSP00000618147
resolver
ensp
ENSP00000618148
resolver
ensp
ENSP00000618149
resolver
genesymbol
IL33
resolver
genesymbol_syn
C9orf26
resolver
genesymbol_syn
IL1F11
resolver
genesymbol_syn
NFHEV
resolver
hgnc
HGNC:16028
resolver
uniprot
B2R8L1
resolver
uniprot
B4DJ35
resolver
uniprot
B4E1Q9
resolver
uniprot
D3DRI5
resolver
uniprot
E7EAX4
resolver
uniprot
Q2YEJ5
resolver
uniprot_entry
IL33_HUMAN
resolver
uniprot_sec
B2R8L1
resolver
uniprot_sec
B4DJ35
resolver
uniprot_sec
B4E1Q9
resolver
uniprot_sec
D3DRI5
resolver
uniprot_sec
E7EAX4
resolver
uniprot_sec
Q2YEJ5
resolver
amino_acid_sequence
MKPKMKYSTNKISTAKWKNTASKALCFKLGKSQQKAKEVCPMYFMKLRSGLMIKKEACYFRRETTKRPSLKTGRKHKRHLVLAACQQQSTVECFAFGISGVQKYTRALHDSSITGISPITEYLASLSTYNDQSITFALEDESYEIYVEDLKKDEKKDKVLLSYYESQHPSNESGDGVDGKMLMVTLSPTKDFWLHANNKEHSVELHKCEKPLPDQAFFVLHNMHSNCVSFECKTDPGVFIGVKDNHLALIKVDSSENLCTENILFKLSET
uniprot
proteins
function
FUNCTION: Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016, PubMed:19841166). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines (PubMed:17853410, PubMed:18836528). Also involved in activation of mast cells, basophils, eosinophils and natural killer cells (PubMed:17853410, PubMed:18836528). Acts as an enhancer of polarization of alternatively activated macrophages (PubMed:19841166). Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528). Induces rapid UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (By similarity). {ECO:0000250|UniProtKB:Q8BVZ5, ECO:0000269|PubMed:16286016, ECO:0000269|PubMed:17853410, ECO:0000269|PubMed:18836528, ECO:0000269|PubMed:19841166}.; FUNCTION: In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074). This form is rapidely lost upon angiogenic or pro-inflammatory activation (PubMed:18787100). {ECO:0000269|PubMed:18787100, ECO:0000269|PubMed:21734074}.
uniprot
proteins
mass_dalton
30759
uniprot
proteins
mutagenesis
MUTAGEN 144; /note="E->K: Decreases affinity for IL1RL1."; /evidence="ECO:0000269|PubMed:23980170"; MUTAGEN 148; /note="E->K: 7-fold decrease in affinity for IL1RL1."; /evidence="ECO:0000269|PubMed:23980170"; MUTAGEN 149; /note="D->K: Almost abolishes binding to IL1RL1."; /evidence="ECO:0000269|PubMed:23980170"; MUTAGEN 165; /note="E->K: 8-fold decrease in affinity for IL1RL1."; /evidence="ECO:0000269|PubMed:23980170"; MUTAGEN 244; /note="D->K: Decreases affinity for IL1RL1."; /evidence="ECO:0000269|PubMed:23980170
uniprot
proteins
post_translational_modification
PTM: The full-length protein can be released from cells and is able to signal via the IL1RL1/ST2 receptor. However, proteolytic processing by CELA1, CSTG/cathepsin G and ELANE/neutrophil elastase produces C-terminal peptides that are more active than the unprocessed full length protein (PubMed:22307629, PubMed:35794369). May also be proteolytically processed by calpains (PubMed:19596270, PubMed:22307629). Proteolytic cleavage mediated by apoptotic caspases including CASP3 and CASP7 results in IL33 inactivation (PubMed:19559631). In vitro proteolytic cleavage by CASP1 was reported (PubMed:16286016, PubMed:19439663) but could not be confirmed in vivo (PubMed:19465481) suggesting that IL33 is probably not a direct substrate for that caspase (PubMed:19439663, PubMed:19465481). {ECO:0000269|PubMed:16286016, ECO:0000269|PubMed:19439663, ECO:0000269|PubMed:19465481, ECO:0000269|PubMed:19559631, ECO:0000269|PubMed:19596270, ECO:0000269|PubMed:22307629, ECO:0000269|PubMed:35794369}.
uniprot
proteins
protein_family
IL-1 family
uniprot
proteins
pubmed
10566975
uniprot
proteins
pubmed
12819012
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16286016
uniprot
proteins
pubmed
17185418
uniprot
proteins
pubmed
17853410
uniprot
proteins
pubmed
18787100
uniprot
proteins
pubmed
18836528
uniprot
proteins
pubmed
19439663
uniprot
proteins
pubmed
19465481
uniprot
proteins
pubmed
19559631
uniprot
proteins
pubmed
19596270
uniprot
proteins
pubmed
19836339
uniprot
proteins
pubmed
19841166
uniprot
proteins
pubmed
21454686
uniprot
proteins
pubmed
21734074
uniprot
proteins
pubmed
22215666
uniprot
proteins
pubmed
22307629
uniprot
proteins
pubmed
23980170
uniprot
proteins
pubmed
29045903
uniprot
proteins
pubmed
32272059
uniprot
proteins
pubmed
35794369
uniprot
proteins
sequence_length
270
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:12819012, ECO:0000269|PubMed:17185418, ECO:0000269|PubMed:18787100, ECO:0000269|PubMed:18836528, ECO:0000269|PubMed:21734074}. Chromosome {ECO:0000269|PubMed:17185418}. Cytoplasm {ECO:0000269|PubMed:32272059}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:22215666}. Secreted {ECO:0000269|PubMed:19465481, ECO:0000269|PubMed:35794369}. Note=Secreted and released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore following cleavage by CELA1 (PubMed:35794369). Associates with heterochromatin and mitotic chromosomes (PubMed:17185418). The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). {ECO:0000269|PubMed:32272059, ECO:0000269|PubMed:35794369}.
uniprot
proteins