Dclre1b
entrez
140917
canonical
uniprot
Q8C7W7
canonical
ensembl
ENSMUSG00000027845
resolver
ensp
ENSMUSP00000029435
resolver
ensp
ENSMUSP00000067695
resolver
genesymbol
Dclre1b
resolver
genesymbol_syn
Snm1b
resolver
uniprot
A0JLW2
resolver
uniprot
B0V3N9
resolver
uniprot
B0V3P0
resolver
uniprot
Q3U4P2
resolver
uniprot
Q3UUC7
resolver
uniprot
Q3UV92
resolver
uniprot
Q6NXL4
resolver
uniprot
Q8BN95
resolver
uniprot
Q8BQS8
resolver
uniprot
Q921S0
resolver
uniprot_entry
DCR1B_MOUSE
resolver
uniprot_sec
A0JLW2
resolver
uniprot_sec
B0V3N9
resolver
uniprot_sec
B0V3P0
resolver
uniprot_sec
Q3U4P2
resolver
uniprot_sec
Q3UUC7
resolver
uniprot_sec
Q3UV92
resolver
uniprot_sec
Q6NXL4
resolver
uniprot_sec
Q8BN95
resolver
uniprot_sec
Q8BQS8
resolver
uniprot_sec
Q921S0
resolver
amino_acid_sequence
MNGVVIPQTPIAVDFWSLRRAGSARLFFLTHMHCDHTVGLSSTWARPLYCSPITACLLHRRLQVSKHWIRALEVGESHVLPLDEIGQETMTVTLIDANHCPGSVMFLFEGYFGTILYTGDFRYTPSMLKEPALILGKQIHTLYLDNTNCNPALVLPSRQEATQQIVQLIRQFPQHNIKIGLYSLGKESLLEQLALEFRTWVVLSPQRLELVQLLGLADVFTVEEEAGRIHAVDHTEICHSAMLQWNQSHPTIAIFPTSRKVRSPHPSIYTVPYSDHSSYSELRAFVAALRPCQVVPIVHQKPCGEFFQDSLSPRLAMPLIPHSVQQYMSSSSRKTNVLWQLERRLKRPRTQGVVFESPEEKANQVKVDRDSKKHKKENLSPWAGHLERLCPHPLQARKQLFPDFCRKERDEPVLFCDSNKMATVLTAPLEFSVQLQPIDEFLFPETREKIGLESPLLSRGDSGSPARGNQSDCVGCGSPPAHISRAVPLTPESRGLALKYLLTPVHFLQAGFSSRNFDKQVEKHQRVQRSSPAVLSPVDVG
uniprot
proteins
ec_number
3.1.-.-
uniprot
proteins
ec_number
3.5.2.6
uniprot
proteins
function
FUNCTION: 5'-3' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity: generates 3' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are vulnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1, TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage: plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (By similarity). Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (By similarity). {ECO:0000250|UniProtKB:Q9H816, ECO:0000269|PubMed:20551906, ECO:0000269|PubMed:20619712}.
uniprot
proteins
mass_dalton
61069
uniprot
proteins
mutagenesis
MUTAGEN 14; /note="D->A: Abolishes exonuclease activity without affecting the telomere localization, leading to impaired 3'-overhang at the leading end telomeres."; /evidence="ECO:0000269|PubMed:20551906"; MUTAGEN 31..35; /note="HMHCD->AMACN: Abolishes exonuclease activity, leading to activate the ATM signaling pathway; when associated with A-230."; /evidence="ECO:0000269|PubMed:20619712"; MUTAGEN 230; /note="H->A: Abolishes exonuclease activity, leading to activate the ATM signaling pathway; when associated with 31-A--N-35."; /evidence="ECO:0000269|PubMed:20619712"; MUTAGEN 500..504; /note="Missing: Abolishes interaction with TERF2 and localization to telomeres, leading to activate the ATM signaling pathway."; /evidence="ECO:0000269|PubMed:20619712
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated, leading to its degradation. Interaction with TERF2 protects it from ubiquitination (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
DNA repair metallo-beta-lactamase (DRMBL) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20551906
uniprot
proteins
pubmed
20619712
uniprot
proteins
sequence_length
541
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome, telomere {ECO:0000269|PubMed:20551906, ECO:0000269|PubMed:20619712}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Note=Mainly localizes to telomeres, recruited via its interaction with TERF2. During mitosis, localizes to the centrosome.
uniprot
proteins