Mob1a
entrez
297387
canonical
uniprot
Q3T1J9
canonical
ensembl
ENSRNOG00000059474
resolver
ensp
ENSRNOP00000072053
resolver
genesymbol
Mob1a
resolver
genesymbol_syn
Mobk1b
resolver
genesymbol_syn
Mobkl1b
resolver
uniprot_entry
MOB1A_RAT
resolver
amino_acid_sequence
MSFLFSSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRQAVMLPEGEDLNEWIAVNTVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEYHWADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDSVMQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLGSKDR
uniprot
proteins
function
FUNCTION: Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38 (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
25080
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1. {ECO:0000250}.
uniprot
proteins
protein_family
MOB1/phocein family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
216
uniprot
proteins