Cln3
entrez
12752
canonical
uniprot
Q61124
canonical
ensembl
ENSMUSG00000030720
resolver
ensp
ENSMUSP00000032962
resolver
ensp
ENSMUSP00000081636
resolver
ensp
ENSMUSP00000095644
resolver
ensp
ENSMUSP00000111973
resolver
ensp
ENSMUSP00000165167
resolver
ensp
ENSMUSP00000337142
resolver
enst
ENSMUST00000032962
resolver
enst
ENSMUST00000084589
resolver
enst
ENSMUST00000098036
resolver
enst
ENSMUST00000116269
resolver
genesymbol
Cln3
resolver
uniprot
F6WW18
resolver
uniprot
O35934
resolver
uniprot
P70400
resolver
uniprot
Q6PAH4
resolver
uniprot_entry
CLN3_MOUSE
resolver
uniprot_entry
F6WW18_MOUSE
resolver
uniprot_entry
Q6PAH4_MOUSE
resolver
uniprot_sec
O35934
resolver
uniprot_sec
P70400
resolver
amino_acid_sequence
MGSSAGSWRRLEDSEREETDSEPQAPRLDSRSVLWKNAVGFWILGLCNNFSYVVMLSAAHDILKQEQASGNQSHVEPGPTPTPHNSSSRFDCNSISTAAVLLADILPTLVIKLLAPLGLHLLPYSPRVLVSGVCSAGSFVLVAFSQSVGLSLCGVVLASISSGLGEVTFLSLTAFYPSAVISWWSSGTGGAGLLGSLSYLGLTQAGLSPQHTLLSMLGIPVLLLASYFLLLTSPEPLDPGGENEAETAARQPLIGTETPESKPGASWDLSLQERWTVFKGLLWYIIPLVLVYFAEYFINQGLFELLFFRNTSLSHAQQYRWYQMLYQAGVFASRSSLQCCRIRFTWVLALLQCLNLALLLADVCLNFLPSIYLIFIIILYEGLLGGAAYVNTFHNIALETSDKHREFAMEAACISDTLGISLSGVLALPLHDFLCHLP
uniprot
proteins
function
FUNCTION: Mediates microtubule-dependent, anterograde transport connecting the Golgi network, endosomes, autophagosomes, lysosomes and plasma membrane, and participates in several cellular processes such as regulation of lysosomal pH, lysosome protein degradation, receptor-mediated endocytosis, autophagy, transport of proteins and lipids from the TGN, apoptosis and synaptic transmission (PubMed:10191118, PubMed:15588329, PubMed:16714284, PubMed:17855597, PubMed:24227717, PubMed:25878248, PubMed:26450516, PubMed:29780879). Facilitates the proteins transport from trans-Golgi network (TGN)-to other membrane compartments such as transport of microdomain-associated proteins to the plasma membrane, IGF2R transport to the lysosome where it regulates the CTSD release leading to regulation of CTSD maturation and thereby APP intracellular processing (PubMed:24227717). Moreover regulates CTSD activity in response to osmotic stress (By similarity). Also binds galactosylceramide and transports it from the trans Golgi to the rafts, which may have immediate and downstream effects on cell survival by modulating ceramide synthesis (PubMed:10191118). At the plasma membrane, regulates actin-dependent events including filopodia formation, cell migration, and pinocytosis through ARF1-CDC42 pathway and also the cytoskeleton organization through interaction with MYH10 and fodrin leading to the regulation of the plasma membrane association of Na+, K+ ATPase complex (PubMed:18621045, PubMed:24792215). Regulates synaptic transmission in the amygdala, hippocampus, and cerebellum through regulation of synaptic vesicles density and their proximity to active zones leading to modulation of short-term plasticity and age-dependent anxious behavior, learning and memory (PubMed:29135436, PubMed:29780879). Regulates autophagic vacuoles (AVs) maturation by modulating the trafficking between endocytic and autophagolysosomal/lysosomal compartments, which involves vesicle fusion leading to regulation of degradation process (PubMed:16714284, PubMed:25878248, PubMed:26450516). Also participates in cellular homeostasis of compounds such as, water, ions, amino acids, proteins and lipids in several tissue namely in brain and kidney through regulation of their transport and synthesis (PubMed:19284480, PubMed:20219947, PubMed:25878248). {ECO:0000250|UniProtKB:Q13286, ECO:0000269|PubMed:10191118, ECO:0000269|PubMed:15588329, ECO:0000269|PubMed:16714284, ECO:0000269|PubMed:17855597, ECO:0000269|PubMed:18621045, ECO:0000269|PubMed:19284480, ECO:0000269|PubMed:20219947, ECO:0000269|PubMed:24227717, ECO:0000269|PubMed:24792215, ECO:0000269|PubMed:25878248, ECO:0000269|PubMed:26450516, ECO:0000269|PubMed:29135436, ECO:0000269|PubMed:29780879}.
uniprot
proteins
mass_dalton
47657
uniprot
proteins
post_translational_modification
PTM: Highly glycosylated. {ECO:0000250|UniProtKB:Q13286}.; PTM: Farnesylation is important for trafficking to lysosomes. {ECO:0000250|UniProtKB:Q13286}.
uniprot
proteins
protein_family
Battenin family
uniprot
proteins
pubmed
10191118
uniprot
proteins
pubmed
10440905
uniprot
proteins
pubmed
10527801
uniprot
proteins
pubmed
11590129
uniprot
proteins
pubmed
12374761
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15588329
uniprot
proteins
pubmed
16714284
uniprot
proteins
pubmed
17189291
uniprot
proteins
pubmed
17855597
uniprot
proteins
pubmed
17962032
uniprot
proteins
pubmed
18621045
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19284480
uniprot
proteins
pubmed
19941651
uniprot
proteins
pubmed
20219947
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24227717
uniprot
proteins
pubmed
24792215
uniprot
proteins
pubmed
25878248
uniprot
proteins
pubmed
26450516
uniprot
proteins
pubmed
29135436
uniprot
proteins
pubmed
29780879
uniprot
proteins
pubmed
8812504
uniprot
proteins
pubmed
9151313
uniprot
proteins
sequence_length
438
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000269|PubMed:15588329}; Multi-pass membrane protein {ECO:0000255}. Late endosome {ECO:0000250|UniProtKB:Q13286}. Lysosome {ECO:0000269|PubMed:11590129, ECO:0000269|PubMed:16714284, ECO:0000269|PubMed:19941651}. Membrane raft {ECO:0000269|PubMed:24227717}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:24227717}. Synapse, synaptosome {ECO:0000269|PubMed:11590129}. Early endosome membrane {ECO:0000269|PubMed:15588329}. Late endosome membrane {ECO:0000269|PubMed:15588329}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:16714284}. Note=Excluded from the synaptic vesicles. {ECO:0000269|PubMed:11590129}.
uniprot
proteins
transmembrane_region
TRANSMEM 38..58; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 128..148; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 152..172; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 183..203; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 278..298; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 347..367; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins