CCS
entrez
9973
canonical
uniprot
O14618
canonical
ensembl
ENSG00000173992
resolver
ensp
ENSP00000436318
resolver
enst
ENST00000533244
resolver
genesymbol
CCS
resolver
hgnc
HGNC:1613
resolver
uniprot
Q2M366
resolver
uniprot
Q8NEV0
resolver
uniprot_entry
CCS_HUMAN
resolver
uniprot_sec
Q2M366
resolver
uniprot_sec
Q8NEV0
resolver
amino_acid_sequence
MASDSGNQGTLCTLEFAVQMTCQSCVDAVRKSLQGVAGVQDVEVHLEDQMVLVHTTLPSQEVQALLEGTGRQAVLKGMGSGQLQNLGAAVAILGGPGTVQGVVRFLQLTPERCLIEGTIDGLEPGLHGLHVHQYGDLTNNCNSCGNHFNPDGASHGGPQDSDRHRGDLGNVRADADGRAIFRMEDEQLKVWDVIGRSLIIDEGEDDLGRGGHPLSKITGNSGERLACGIIARSAGLFQNPKQICSCDGLTIWEERGRPIAGKGRKESAQPPAHL
uniprot
proteins
function
FUNCTION: Delivers copper to copper zinc superoxide dismutase (SOD1). {ECO:0000269|PubMed:9295278}.
uniprot
proteins
mass_dalton
29041
uniprot
proteins
mutagenesis
MUTAGEN 22; /note="C->S: Reduces copper binding by half; when associated with S-25. Negligible effect on zinc binding."; /evidence="ECO:0000269|PubMed:15736924"; MUTAGEN 25; /note="C->S: Reduces copper binding by half; when associated with S-22. Negligible effect on zinc binding."; /evidence="ECO:0000269|PubMed:15736924"; MUTAGEN 244; /note="C->S: Reduces copper binding by half; when associated with S-246. Negligible effect on zinc binding."; /evidence="ECO:0000269|PubMed:15736924"; MUTAGEN 246; /note="C->S: Reduces copper binding by half; when associated with S-244. Negligible effect on zinc binding."; /evidence="ECO:0000269|PubMed:15736924
uniprot
proteins
post_translational_modification
PTM: Ubiquitinion by XIAP/BIRC4 leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. XIAP/BIRC4 preferentially ubiquitinates at Lys-241. {ECO:0000269|PubMed:20154138}.
uniprot
proteins
protein_family
Cu-Zn superoxide dismutase family
uniprot
proteins
pubmed
10677207
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15736924
uniprot
proteins
pubmed
20154138
uniprot
proteins
pubmed
20595380
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22508683
uniprot
proteins
pubmed
23625804
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
31292775
uniprot
proteins
pubmed
9295278
uniprot
proteins
pubmed
9726962
uniprot
proteins
sequence_length
274
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:9726962}.
uniprot
proteins