ESRRG
entrez
2104
canonical
uniprot
P62508
canonical
ensembl
ENSG00000196482
resolver
ensp
ENSP00000352077
resolver
ensp
ENSP00000353108
resolver
ensp
ENSP00000355225
resolver
ensp
ENSP00000355904
resolver
ensp
ENSP00000355905
resolver
ensp
ENSP00000355907
resolver
ensp
ENSP00000375761
resolver
ensp
ENSP00000386171
resolver
ensp
ENSP00000417374
resolver
ensp
ENSP00000418629
resolver
ensp
ENSP00000419155
resolver
ensp
ENSP00000419594
resolver
ensp
ENSP00000500992
resolver
ensp
ENSP00000712343
resolver
genesymbol
ERRgamma
resolver
genesymbol
ESRRG
resolver
genesymbol
NR3B3
resolver
genesymbol_syn
ERR3
resolver
genesymbol_syn
ERRG2
resolver
genesymbol_syn
KIAA0832
resolver
genesymbol_syn
NR3B3
resolver
hgnc
HGNC:3474
resolver
uniprot
A8K4I0
resolver
uniprot
A8K6I2
resolver
uniprot
B3KY84
resolver
uniprot
B7Z5E9
resolver
uniprot
C0SQ93
resolver
uniprot
E9PGB7
resolver
uniprot
F1D8R5
resolver
uniprot
F1D8R6
resolver
uniprot
F8W8J3
resolver
uniprot
O75454
resolver
uniprot
O96021
resolver
uniprot
Q68DA0
resolver
uniprot
Q6P274
resolver
uniprot
Q6PK28
resolver
uniprot
Q6TS38
resolver
uniprot
Q9R1F3
resolver
uniprot
Q9UNJ4
resolver
uniprot_entry
B7Z5E9_HUMAN
resolver
uniprot_entry
C0SQ93_HUMAN
resolver
uniprot_entry
ERR3_HUMAN
resolver
uniprot_entry
F1D8R5_HUMAN
resolver
uniprot_entry
F1D8R6_HUMAN
resolver
uniprot_sec
A8K4I0
resolver
uniprot_sec
A8K6I2
resolver
uniprot_sec
B3KY84
resolver
uniprot_sec
E9PGB7
resolver
uniprot_sec
F8W8J3
resolver
uniprot_sec
O75454
resolver
uniprot_sec
O96021
resolver
uniprot_sec
Q68DA0
resolver
uniprot_sec
Q6P274
resolver
uniprot_sec
Q6PK28
resolver
uniprot_sec
Q6TS38
resolver
uniprot_sec
Q9R1F3
resolver
uniprot_sec
Q9UNJ4
resolver
amino_acid_sequence
MDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV
uniprot
proteins
function
FUNCTION: Orphan receptor that acts as a transcription activator in the absence of bound ligand. Binds specifically to an estrogen response element and activates reporter genes controlled by estrogen response elements (By similarity). Induces the expression of PERM1 in the skeletal muscle. {ECO:0000250, ECO:0000269|PubMed:11864604, ECO:0000269|PubMed:18063693, ECO:0000269|PubMed:19067653, ECO:0000269|PubMed:23836911}.
uniprot
proteins
mass_dalton
51306
uniprot
proteins
mutagenesis
MUTAGEN 38; /note="F->A,E: No effect on transcriptional activity."; /evidence="ECO:0000269|PubMed:19067653"; MUTAGEN 39; /note="I->A: 4-fold increase in transcriptional activity."; /evidence="ECO:0000269|PubMed:19067653"; MUTAGEN 40; /note="K->R: Abolishes sumoylation. 7-fold increase in transcriptional activity."; /evidence="ECO:0000269|PubMed:16371476, ECO:0000269|PubMed:18063693, ECO:0000269|PubMed:19067653"; MUTAGEN 41; /note="T->A: No effect on transcriptional activity."; /evidence="ECO:0000269|PubMed:19067653"; MUTAGEN 42; /note="E->A: 4-fold increase in transcriptional activity."; /evidence="ECO:0000269|PubMed:19067653"; MUTAGEN 44; /note="S->A,E: No effect on transcriptional activity."; /evidence="ECO:0000269|PubMed:19067653"; MUTAGEN 45; /note="S->A: Abolishes sumoylation. Increased transcriptional activity."; /evidence="ECO:0000269|PubMed:18063693, ECO:0000269|PubMed:19067653"; MUTAGEN 45; /note="S->D: No change in sumoylation nor transcriptional activity."; /evidence="ECO:0000269|PubMed:18063693, ECO:0000269|PubMed:19067653
uniprot
proteins
post_translational_modification
PTM: Acetylated by PCAF/KAT2 (in vitro). {ECO:0000269|PubMed:20484414}.; PTM: Sumoylation on Lys-40 is enhanced by phosphorylation at Ser-45 and represses transcriptional activity. {ECO:0000269|PubMed:16371476, ECO:0000269|PubMed:18063693, ECO:0000269|PubMed:19067653}.; PTM: Phosphorylation on Ser-45 enhances sumoylation on Lys-40 thus repressing transcriptional activity. {ECO:0000269|PubMed:16371476, ECO:0000269|PubMed:18063693, ECO:0000269|PubMed:19067653}.
uniprot
proteins
protein_family
NR3 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
10048485
uniprot
proteins
pubmed
10072763
uniprot
proteins
pubmed
10428842
uniprot
proteins
pubmed
10707956
uniprot
proteins
pubmed
11864604
uniprot
proteins
pubmed
14651967
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16307879
uniprot
proteins
pubmed
16371476
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16990259
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18063693
uniprot
proteins
pubmed
19067653
uniprot
proteins
pubmed
20484414
uniprot
proteins
pubmed
23836911
uniprot
proteins
pubmed
9676434
uniprot
proteins
sequence_length
458
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins