Ppp2r2b
entrez
60660
canonical
uniprot
P36877
canonical
ensembl
ENSRNOG00000018851
resolver
ensembl
ENSRNOG00055018620
resolver
ensembl
ENSRNOG00060011432
resolver
ensembl
ENSRNOG00065019535
resolver
ensp
ENSRNOP00000041264
resolver
ensp
ENSRNOP00000071716
resolver
ensp
ENSRNOP00000071824
resolver
ensp
ENSRNOP00000081049
resolver
ensp
ENSRNOP00000093860
resolver
ensp
ENSRNOP00000096088
resolver
ensp
ENSRNOP00000107558
resolver
ensp
ENSRNOP00000111041
resolver
enst
ENSRNOT00000041188
resolver
enst
ENSRNOT00000091634
resolver
enst
ENSRNOT00000097489
resolver
enst
ENSRNOT00000112290
resolver
enst
ENSRNOT00000157140
resolver
genesymbol
Ppp2r2b
resolver
uniprot
A0A0G2K165
resolver
uniprot
A0A8I5ZU97
resolver
uniprot
A0A8I6ANA4
resolver
uniprot
A0ABK0LAF6
resolver
uniprot
Q80W84
resolver
uniprot
Z4YNW7
resolver
uniprot_entry
2ABB_RAT
resolver
uniprot_entry
A0A0G2K165_RAT
resolver
uniprot_entry
A0A8I5ZU97_RAT
resolver
uniprot_entry
A0A8I6ANA4_RAT
resolver
uniprot_entry
A0ABK0LAF6_RAT
resolver
uniprot_entry
Z4YNW7_RAT
resolver
uniprot_sec
Q80W84
resolver
amino_acid_sequence
MEEDIDTRKINNSFLRDHSYATEADIISTVEFNHTGELLATGDKGGRVVIFQREQESKNQVHRRGEYNVYSTFQSHEPEFDYLKSLEIEEKINKIRWLPQQNAAYFLLSTNDKTVKLWKVSERDKRPEGYNLKDEEGRLRDPATITTLRVPVLRPMDLMVEATPRRVFANAHTYHINSISVNSDYETYMSADDLRINLWNFEITNQSFNIVDIKPANMEELTEVITAAEFHPHHCNTFVYSSSKGTIRLCDMRASALCDRHTKFFEEPEDPSNRSFFSEIISSISDVKFSHSGRYIMTRDYLTAKVWDLNMENRPVETYQVHDYLRSKLCSLYENDCIFDKFECVWNGSDSVIMTGSYNNFFRMFDRNTKRDVTLEASRENSKPRAILKPRKVCVGGKRRKDEISVDSLDFSKKILHTAWHPSENIIAVAATNNLYIFQDKVN
uniprot
proteins
function
FUNCTION: The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity. Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance. {ECO:0000269|PubMed:12716901, ECO:0000269|PubMed:18940801}.
uniprot
proteins
mass_dalton
51668
uniprot
proteins
mutagenesis
MUTAGEN 165..166; /note="RR->EE: Inhibits incorporation into the PP2A holoenzyme complex and proapoptotic activity."; /evidence="ECO:0000269|PubMed:12716901
uniprot
proteins
protein_family
Phosphatase 2A regulatory subunit B family
uniprot
proteins
pubmed
12716901
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15923182
uniprot
proteins
pubmed
16641100
uniprot
proteins
pubmed
18940801
uniprot
proteins
pubmed
7607250
uniprot
proteins
pubmed
8389301
uniprot
proteins
sequence_length
443
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm. Cytoplasm, cytoskeleton {ECO:0000250}. Membrane {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm. Mitochondrion. Mitochondrion outer membrane. Note=Under basal conditions, localizes to both cytosolic and mitochondrial compartments. Relocalizes from the cytosolic to the mitochondrial compartment during apoptosis. Its targeting to the outer mitochondrial membrane (OMM) involves an association with import receptors of the TOM complex and is required to promote proapoptotic activity.
uniprot
proteins