Bace2
entrez
288227
canonical
uniprot
Q6IE75
canonical
ensembl
ENSRNOG00000001953
resolver
ensp
ENSRNOP00000002679
resolver
enst
ENSRNOT00000002679
resolver
genesymbol
Bace2
resolver
uniprot
B2GVB0
resolver
uniprot_entry
BACE2_RAT
resolver
uniprot_sec
B2GVB0
resolver
amino_acid_sequence
MGALLRALLLPLLAQWLLRAVPVLAPAPFTLPLQVAGAANHRASTVPGLGTPELPRADGLALALEPARATANFLAMVDNLQGDSGRGYYLEMLIGTPPQKVRILVDTGSSNFAVAGAPHSYIDTYFDSESSSTYHSKGFEVTVKYTQGSWTGFVGEDLVTIPKGFNSSFLVNIATIFESENFFLPGIKWNGILGLAYAALAKPSSSLETFFDSLVAQAKIPDIFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARTSLIPEFSDGFWTGAQLACWTNSETPWAYFPKISIYLRDENASRSFRITILPQLYIQPMMGAGFNYECYRFGISSSTNALVIGATVMEGFYVVFDRAQRRVGFAVSPCAEIAGTTVSEISGPFSTEDIASNCVPAQALNEPILWIVSYALMSVCGAILLVLILLLLFPLHCRHAPRDPEVVNDESSLVRHRWK
uniprot
proteins
ec_number
3.4.23.45
uniprot
proteins
function
FUNCTION: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus. This is a prerequisite step for subsequent processing and assembly of PMEL fibrils into amyloid sheets. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells. {ECO:0000250|UniProtKB:Q9Y5Z0}.
uniprot
proteins
mass_dalton
55858
uniprot
proteins
post_translational_modification
PTM: Undergoes autoproteolytic cleavage. {ECO:0000250|UniProtKB:Q9Y5Z0}.; PTM: Glycosylated. {ECO:0000250|UniProtKB:Q9Y5Z0}.
uniprot
proteins
protein_family
Peptidase A1 family
uniprot
proteins
pubmed
15060002
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
514
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q9Y5Z0}; Single-pass type I membrane protein {ECO:0000255}. Golgi apparatus {ECO:0000250|UniProtKB:Q9Y5Z0}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9Y5Z0}. Endosome {ECO:0000250|UniProtKB:Q9Y5Z0}. Melanosome {ECO:0000250|UniProtKB:Q9Y5Z0}. Note=Colocalizes with PMEL in stage I and II melanosomes. {ECO:0000250|UniProtKB:Q9Y5Z0}.
uniprot
proteins
transmembrane_region
TRANSMEM 470..490; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins