GLRA3
entrez
8001
canonical
uniprot
O75311
canonical
ensembl
ENSG00000145451
resolver
ensp
ENSP00000274093
resolver
ensp
ENSP00000345284
resolver
genesymbol
GLRA3
resolver
hgnc
HGNC:4328
resolver
uniprot
D3DP44
resolver
uniprot
O75816
resolver
uniprot
Q5D0E3
resolver
uniprot
Q9UPF3
resolver
uniprot_entry
GLRA3_HUMAN
resolver
uniprot_entry
Q9UPF3_HUMAN
resolver
uniprot_sec
D3DP44
resolver
uniprot_sec
O75816
resolver
uniprot_sec
Q5D0E3
resolver
amino_acid_sequence
MAHVRHFRTLVSGFYFWEAALLLSLVATKETDSARSRSAPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRKNKTEAFALEKFYRFSDMDDEVRESRFSFTAYGMGPCLQAKDGMTPKGPNHPVQVMPKSPDEMRKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIYKILRHEDIHQQQD
uniprot
proteins
function
FUNCTION: Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:26416729, PubMed:9677400). Channel characteristics depend on the subunit composition; heteropentameric channels display faster channel closure (By similarity). Plays an important role in the down-regulation of neuronal excitability (By similarity). Contributes to the generation of inhibitory postsynaptic currents (By similarity). Contributes to increased pain perception in response to increased prostaglandin E2 levels (By similarity). Plays a role in cellular responses to ethanol (By similarity). {ECO:0000250|UniProtKB:P24524, ECO:0000250|UniProtKB:Q91XP5, ECO:0000269|PubMed:26416729, ECO:0000269|PubMed:9677400}.
uniprot
proteins
mass_dalton
53800
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKA; this causes down-regulation of channel activity. {ECO:0000250|UniProtKB:P24524}.
uniprot
proteins
protein_family
GLRA3 sub-subfamily
uniprot
proteins
protein_family
Glycine receptor (TC 1.A.9.3) subfamily
uniprot
proteins
protein_family
Ligand-gated ion channel (TC 1.A.9) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
26416729
uniprot
proteins
pubmed
9677400
uniprot
proteins
sequence_length
464
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Postsynaptic cell membrane {ECO:0000250|UniProtKB:P24524}; Multi-pass membrane protein {ECO:0000305}. Perikaryon {ECO:0000250|UniProtKB:P24524}. Cell projection, dendrite {ECO:0000250|UniProtKB:P24524}. Synapse {ECO:0000250|UniProtKB:P24524}. Cell membrane {ECO:0000269|PubMed:26416729, ECO:0000269|PubMed:9677400}; Multi-pass membrane protein {ECO:0000269|PubMed:26416729}. Note=Partially colocalizes with GPHN that is known to mediate receptor clustering at postsynaptic membranes. {ECO:0000250|UniProtKB:P24524}.
uniprot
proteins
transmembrane_region
TRANSMEM 256..277; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:26416729"; TRANSMEM 283..303; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:26416729"; TRANSMEM 315..335; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:26416729"; TRANSMEM 431..451; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:26416729
uniprot
proteins