Bcam
entrez
57278
canonical
uniprot
Q9R069
canonical
ensembl
ENSMUSG00000002980
resolver
ensp
ENSMUSP00000003061
resolver
enst
ENSMUST00000003061
resolver
genesymbol
Bcam
resolver
genesymbol_syn
Gplu
resolver
genesymbol_syn
Lu
resolver
uniprot
Q9ESS5
resolver
uniprot
Q9JKB2
resolver
uniprot_entry
BCAM_MOUSE
resolver
uniprot_sec
Q9ESS5
resolver
uniprot_sec
Q9JKB2
resolver
amino_acid_sequence
MEPPDARAGLLWLTFLLSGYSGAQAELHVSVPPRVEVMRGEQVALDCTPREHPEHYVLEWFLVDGTGARHRLASVEPQGSEFLGTVHSLGRVPPYEVDSRGRLVIAKVQVGDGRDYVCVVKAGAAGTSEATSSVRVFATPEDTEVSPNKGTLSVMDQFAQEIATCSSNNGNPVPRITWYRNGQRLEVPMEVNQKGYITIRTVREASGLYSLTSTLYLRLHKDDRDANFHCAAHYDLPSGQHGRLDSHTFRLTLHYPTEHVEFWVGSPSTTEGWVREGDAVQLLCQGDGSPSPEYSFFRQQGTQEEQLNVNLKGNLTLERVHRNQSGIYGCRVEDYDADEEVQLVKKLKLHVAYLDPLELSVPEELFVFLNSSSTVVNCSARGLPTPTVRWTKDSVTLADGPMLSLQSVTFDSAGTYTCEASTPTVPLLSRTQSFQLIVQGAPELKPNEIMPKSGNSWTEGDEVMLTCSARGFPEPKLTWSQRGDTPAEPPFEGRGWKSSSLMVKVTSALSREGVSCEASNIHGKKGHVFHFGSVAPQTAQAGVAVMAVAVSVGLLLLVVAAFYCMRRKGRPGCCRRAEKGAPPAREPELSHSGSERPEHTGLLMGGPSGGGRGGSGGFGDEC
uniprot
proteins
function
FUNCTION: Transmembrane glycoprotein that functions as both a receptor and an adhesion molecule playing a crucial role in cell adhesion, motility, migration and invasion. Extracellular domain enables binding to extracellular matrix proteins, such as laminin, integrin and other ligands while its intracellular domain interacts with cytoskeletal proteins like hemoglobin, facilitating cell signal transduction. Serves as a receptor for laminin alpha-5/LAMA5 to promote cell adhesion. Mechanistically, JAK2 induces BCAM phosphorylation and activates its adhesion to laminin by stimulating a Rap1/AKT signaling pathway in the absence of EPOR. {ECO:0000250|UniProtKB:P50895}.
uniprot
proteins
mass_dalton
67670
uniprot
proteins
post_translational_modification
PTM: Epinephrine-stimulated phosphorylation of Ser-615 by PKA enhances adhesion to laminin. Ser-615 can also be phosphorylated by AKT1. {ECO:0000250|UniProtKB:P50895}.
uniprot
proteins
pubmed
10630290
uniprot
proteins
pubmed
11507772
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
622
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P50895}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P50895}.
uniprot
proteins
transmembrane_region
TRANSMEM 542..562; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins