Brd3
entrez
67382
canonical
uniprot
Q8K2F0
canonical
ensembl
ENSMUSG00000026918
resolver
ensp
ENSMUSP00000028282
resolver
ensp
ENSMUSP00000076918
resolver
ensp
ENSMUSP00000109574
resolver
ensp
ENSMUSP00000114422
resolver
ensp
ENSMUSP00000128812
resolver
ensp
ENSMUSP00000224359
resolver
genesymbol
Brd3
resolver
genesymbol_syn
Fsrg2
resolver
genesymbol_syn
Orfx
resolver
uniprot
Q3TUI3
resolver
uniprot
Q5CCJ9
resolver
uniprot
Q8C665
resolver
uniprot
Q8CAX7
resolver
uniprot
Q9JI25
resolver
uniprot_entry
BRD3_MOUSE
resolver
uniprot_entry
Q3TUI3_MOUSE
resolver
uniprot_entry
Q5CCJ9_MOUSE
resolver
uniprot_sec
Q8C665
resolver
uniprot_sec
Q8CAX7
resolver
uniprot_sec
Q9JI25
resolver
amino_acid_sequence
MSTTAAAPTGIPAVPGPVNPPPPEVSNPSKPGRKTNQLQYMQNVVVKTLWKHQFAWPFYQPVDAIKLNLPDYHKIIKNPMDMGTIKKRLENNYYWSASECMQDFNTMFTNCYIYNKPTDDIVLMAQALEKIFLQKVAQMPQEEVELLPPAPKGKGRKPAAGAQNAGSQQVAAVSSVSPATPFQNIPPTVSQTPVIAATPVPTITANVTSVPVPPPAAPPPPATPIVPVVPPTPPVVKKKGVKRKADTTTPTTSAITASRSESPPPLSEPKQAKVVARRESGGRPIKPPKKDLEDGEVPQHAGKKGKLSEHLRHCDSILREMLSKKHAAYAWPFYKPVDAEALELHDYHDIIKHPMDLSTVKRKMDSREYPDAQGFAADIRLMFSNCYKYNPPDHEVVAMARKLQDVFEMRFAKMPDEPMEAPALPAPTAPIVSKGAESSRSSEESSSDSGSSDSEEERATRLAELQEQLKAVHEQLAALSQAPVNKPKKKKEKKEKEKKKKDKDKDKEKEKHKAKSEEEKKAKAAPAAKQAQQKKAPTKKANSTTTASRQLKKGGKQASASYDSEEEEEGLPMSYDEKRQLSLDINRLPGEKLGRVVHIIQSREPSLRDSNPDEIEIDFETLKPTTLRELERYVKSCLQKKQRKPLSTSGKKQAAKSKEELAQEKKKELEKRLQDVSGQLNSKKPTKKEKSGSAPSGGPSRLSSSSSSESASSSSSGSSSDSSDSE
uniprot
proteins
function
FUNCTION: Chromatin reader that recognizes and binds acetylated histones, thereby controlling gene expression and remodeling chromatin structures (PubMed:21536911). Recruits transcription factors and coactivators to target gene sites, and activates RNA polymerase II machinery for transcriptional elongation (By similarity). In vitro, binds acetylated lysine residues on the N-terminus of histone H2A, H2B, H3 and H4 (PubMed:21536911). Involved in endoderm differentiation via its association with long non-coding RNA (lncRNA) DIGIT: BRD3 undergoes liquid-liquid phase separation upon binding to lncRNA DIGIT, promoting binding to histone H3 acetylated at 'Lys-18' (H3K18ac) to induce endoderm gene expression (PubMed:32895492). Also binds non-histones acetylated proteins, such as GATA1 and GATA2: regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (PubMed:21536911, PubMed:21555453). {ECO:0000250|UniProtKB:Q15059, ECO:0000269|PubMed:21536911, ECO:0000269|PubMed:21555453, ECO:0000269|PubMed:32895492}.
uniprot
proteins
mass_dalton
79762
uniprot
proteins
protein_family
BET family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21536911
uniprot
proteins
pubmed
21555453
uniprot
proteins
pubmed
32895492
uniprot
proteins
sequence_length
726
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21536911}. Chromosome {ECO:0000269|PubMed:21536911}. Note=Detected on chromatin. {ECO:0000269|PubMed:21536911}.
uniprot
proteins