Cep78
entrez
208518
canonical
uniprot
Q6IRU7
canonical
ensembl
ENSMUSG00000041491
resolver
ensp
ENSMUSP00000037596
resolver
ensp
ENSMUSP00000157915
resolver
ensp
ENSMUSP00000288840
resolver
ensp
ENSMUSP00000288842
resolver
ensp
ENSMUSP00000288845
resolver
ensp
ENSMUSP00000340807
resolver
enst
ENSMUST00000047704
resolver
enst
ENSMUST00000235718
resolver
genesymbol
Cep78
resolver
uniprot
A0A494BA29
resolver
uniprot_entry
A0A494BA29_MOUSE
resolver
uniprot_entry
CEP78_MOUSE
resolver
amino_acid_sequence
MIDSVKLRRDCAADFFSHYEYLCALQDSVPLPAVRACLRDGVLDFNADRLRAVDWAPLLSTLRVNRDLPLVAIKSSFQPWLGETVLRSGGADTHRICRNRVPAVRSKDISFQLCKALRGCLSVSGVLRNLELNGLILRERDLTSLTKGLSKSTSLVHLSLANCPIGDGGLEIICQGIKNSVTLKTVNFTGCNLTWQGACHMAKILKYQTMRRHEETWAESLRYRRPDLDCMAGLRRITLNCNTLIGDQGASAFADSLSEDLWLRALDLQQCGLTSEGAKALLEALETNRTLVVLDIRKNPLIDHSMMKAVIKKVLQNGRSADSEYQWVTSPSSKEPSKTAKQRKKTIVLGSSRKGKATIRIGLATKKPSSNGRKQGLGKDCYAPNPLPPGASGFLPWRTAERAKRSRSSSLIKTRDLSNHLKKSDFPVTVTVESPSSSETDETEDSSESVQEAPQKTSIKEETLQEKLEECLRQLKEERVIRLKADKRVSELEHENAQLRNINFSLSEALHAQSLTNMILDDEGVLGSIENSFQKFHAFLDLLKDAGLGQLATMAGIDQSDFHLLGRPQMNSTVNTPIQEQKALEDETLHPKQTATGQMQDIRFQKITSDALIPLPLNTVQDPASAQEAVGASRDHLGVVGLEQQEGSAAGFIAKTGSPLAGGIPGGRSQREEEVLSKHSRSSSEKGSTASEPSRRPSAERHPRKDLLSDADPPGNSESKGPGDRRSLLNEPIKSESLKKCISIKKENRIVTVSSKTIKSKPNLLEHSESDTLGSDFELQERVHSSAHLT
uniprot
proteins
function
FUNCTION: Centriole wall protein that localizes to mature centrioles and regulates centriole and cilia biogenesis (PubMed:36206347, PubMed:36756949). Involved in centrosome duplication: required for efficient PLK4 centrosomal localization and PLK4-induced overduplication of centrioles (By similarity). Involved in cilium biogenesis and controls cilium length (PubMed:36206347, PubMed:36756949). Acts as a regulator of protein stability by preventing ubiquitination of centrosomal proteins, such as CCP110 and tektins (PubMed:36206347). Associates with the EDVP complex, preventing ubiquitination and degradation of CCP110 (By similarity). Promotes deubiquitination of tektin proteins (TEKT1, TEKT2, TEK3, TEKT4 and TEKT5) via its interaction with USP16 (PubMed:36206347). {ECO:0000250|UniProtKB:Q5JTW2, ECO:0000269|PubMed:36206347, ECO:0000269|PubMed:36756949}.
uniprot
proteins
mass_dalton
86890
uniprot
proteins
protein_family
CEP78 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
27588451
uniprot
proteins
pubmed
27588452
uniprot
proteins
pubmed
36206347
uniprot
proteins
pubmed
36756949
uniprot
proteins
sequence_length
790
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q5JTW2}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:36206347}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q5JTW2}. Note=Mainly localizes at the centriolar wall, but also found in the pericentriolar material. Expressed in photoreceptor inner segment. {ECO:0000269|PubMed:27588452}.
uniprot
proteins