SLIRP
entrez
81892
canonical
uniprot
Q9GZT3
canonical
ensembl
ENSG00000119705
resolver
ensp
ENSP00000238688
resolver
ensp
ENSP00000450909
resolver
ensp
ENSP00000478794
resolver
enst
ENST00000613856
resolver
genesymbol
SLIRP
resolver
genesymbol_syn
C14orf156
resolver
hgnc
HGNC:20495
resolver
uniprot
A0A087WUN7
resolver
uniprot
J3KMY7
resolver
uniprot_entry
A0A087WUN7_HUMAN
resolver
uniprot_entry
SLIRP_HUMAN
resolver
uniprot_sec
J3KMY7
resolver
amino_acid_sequence
MAASAARGAAALRRSINQPVAFVRRIPWTAASSQLKEHFAQFGHVRRCILPFDKETGFHRGLGWVQFSSEEGLRNALQQENHIIDGVKVQVHTRRPKLPQTSDDEKKDF
uniprot
proteins
function
FUNCTION: RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation. {ECO:0000269|PubMed:16762838}.
uniprot
proteins
mass_dalton
12349
uniprot
proteins
mutagenesis
MUTAGEN 7; /note="R->A: Impairs corepressor activity; when associated with 13-A-A-14."; /evidence="ECO:0000269|PubMed:16762838"; MUTAGEN 13..14; /note="RR->AA: Impairs corepressor activity; when associated with A-7."; /evidence="ECO:0000269|PubMed:16762838"; MUTAGEN 24..25; /note="RR->AA: Impairs SRA-mediated repression; when associated with A-62."; /evidence="ECO:0000269|PubMed:16762838"; MUTAGEN 62; /note="L->A: Impairs SRA-mediated repression; when associated with 24-A-A-25."; /evidence="ECO:0000269|PubMed:16762838
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16762838
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
sequence_length
109
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:16762838}. Nucleus {ECO:0000269|PubMed:16762838}. Note=Predominantly mitochondrial. Some fraction is nuclear. In the nucleus, it is recruited to nuclear receptor target promoters.
uniprot
proteins