Rccd1
entrez
269955
canonical
uniprot
Q8BTU7
canonical
ensembl
ENSMUSG00000038930
resolver
ensp
ENSMUSP00000048043
resolver
ensp
ENSMUSP00000186153
resolver
ensp
ENSMUSP00000186155
resolver
genesymbol
Rccd1
resolver
uniprot
Q6IS64
resolver
uniprot
Q8BJF2
resolver
uniprot
Q8C0K3
resolver
uniprot_entry
RCCD1_MOUSE
resolver
uniprot_sec
Q6IS64
resolver
uniprot_sec
Q8BJF2
resolver
uniprot_sec
Q8C0K3
resolver
amino_acid_sequence
MAEKRHGAWFGFGFCGFGQALGSGNSHHSVYSPEPLHASDDICQVSAGWSYTALVTRGGRVELSGSVSGAADGCRDVWASEELLVLLRNKGGSSTEVQAWVPGSALQGEPLWVQNLVSGAKGQGEDEPSRESRMGTLPLLPCARAYVTPEPPFCQPLAPELRVRQLELGAEHVLLLCAAGQVFSWGAGRHGQLGHGTLEAELEPRLLEALQGLRMAKVAAGGWHSVCLSETGDIYIWGWNESGQLALPTRSGTENKAEREEATELNEDGLKEELAVADAGAPAHFIAIQPFPALLDLPLGSDAVMASCGSRHTAVVTRTGELYTWGWGKYGQLGHKDSTSLDRPCCVEYFVERQLEVRAVTCGPWNTYVYAMERDKS
uniprot
proteins
function
FUNCTION: Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, is involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha-tubulin deacetylation and cytoskeletal microtubule stability, thereby promoting cell migration and TGF-beta-induced epithelial to mesenchymal transition (EMT), potentially through the inhibition of KDM8. {ECO:0000250|UniProtKB:A6NED2}.
uniprot
proteins
mass_dalton
40591
uniprot
proteins
post_translational_modification
PTM: Specifically hydroxylated (with R stereochemistry) at C-3 of ARG-141 by KDM8. {ECO:0000250|UniProtKB:A6NED2}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
377
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:A6NED2}. Note=Colocalizes with trimethylated 'Lys-9' of histone H3 (H3K9me3). {ECO:0000250|UniProtKB:A6NED2}.
uniprot
proteins