ITLN1
entrez
55600
canonical
uniprot
Q8WWA0
canonical
ensembl
ENSG00000179914
resolver
ensp
ENSP00000323587
resolver
ensp
ENSP00000566931
resolver
ensp
ENSP00000566932
resolver
ensp
ENSP00000566933
resolver
ensp
ENSP00000566934
resolver
ensp
ENSP00000630684
resolver
ensp
ENSP00000630685
resolver
ensp
ENSP00000630686
resolver
ensp
ENSP00000630687
resolver
enst
ENST00000326245
resolver
enst
ENST00000896872
resolver
enst
ENST00000896873
resolver
enst
ENST00000896874
resolver
enst
ENST00000896875
resolver
enst
ENST00000960625
resolver
enst
ENST00000960626
resolver
enst
ENST00000960627
resolver
enst
ENST00000960628
resolver
genesymbol
ITLN1
resolver
genesymbol_syn
INTL
resolver
genesymbol_syn
ITLN
resolver
genesymbol_syn
LFR
resolver
hgnc
HGNC:18259
resolver
uniprot
Q5IWS4
resolver
uniprot
Q5VYI4
resolver
uniprot
Q6YDJ3
resolver
uniprot
Q9NP67
resolver
uniprot_entry
ITLN1_HUMAN
resolver
uniprot_sec
Q5IWS4
resolver
uniprot_sec
Q5VYI4
resolver
uniprot_sec
Q6YDJ3
resolver
uniprot_sec
Q9NP67
resolver
amino_acid_sequence
MNQLSFLLFLIATTRGWSTDEANTYFKEWTCSSSPSLPRSCKEIKDECPSAFDGLYFLRTENGVIYQTFCDMTSGGGGWTLVASVHENDMRGKCTVGDRWSSQQGSKAVYPEGDGNWANYNTFGSAEAATSDDYKNPGYYDIQAKDLGIWHVPNKSPMQHWRNSSLLRYRTDTGFLQTLGHNLFGIYQKYPVKYGEGKCWTDNGPVIPVVYDFGDAQKTASYYSPYGQREFTAGFVQFRVFNNERAANALCAGMRVTGCNTEHHCIGGGGYFPEASPQQCGDFSGFDWSGYGTHVGYSSSREITEAAVLLFYR
uniprot
proteins
function
FUNCTION: Lectin that specifically recognizes microbial carbohydrate chains in a calcium-dependent manner (PubMed:11313366, PubMed:26148048). Binds to microbial glycans that contain a terminal acyclic 1,2-diol moiety, including beta-linked D-galactofuranose (beta-Galf), D-phosphoglycerol-modified glycans, D-glycero-D-talo-oct-2-ulosonic acid (KO) and 3-deoxy-D-manno-oct-2-ulosonic acid (KDO) (PubMed:26148048). Binds to glycans from Gram-positive and Gram-negative bacteria, including K.pneumoniae, S.pneumoniae, Y.pestis, P.mirabilis and P.vulgaris (PubMed:26148048). Does not bind human glycans (PubMed:26148048). Probably plays a role in the defense system against microorganisms (Probable). May function as adipokine that has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes (PubMed:16531507). Increases AKT phosphorylation in the absence and presence of insulin (PubMed:16531507). May interact with lactoferrin/LTF and increase its uptake, and may thereby play a role in iron absorption (PubMed:11747454, PubMed:23921499). {ECO:0000269|PubMed:11313366, ECO:0000269|PubMed:16531507, ECO:0000269|PubMed:23921499, ECO:0000269|PubMed:26148048, ECO:0000305, ECO:0000305|PubMed:11747454}.
uniprot
proteins
mass_dalton
34962
uniprot
proteins
mutagenesis
MUTAGEN 31; /note="C->S: Forms mainly monomers; when associated with S-48."; /evidence="ECO:0000269|PubMed:17621593"; MUTAGEN 48; /note="C->S: Forms mainly dimers. Forms mainly monomers; when associated with S-31."; /evidence="ECO:0000269|PubMed:17621593
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:11313366, ECO:0000269|PubMed:17621593}.
uniprot
proteins
pubmed
11181563
uniprot
proteins
pubmed
11313366
uniprot
proteins
pubmed
11747454
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14720597
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16531507
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17621593
uniprot
proteins
pubmed
23921499
uniprot
proteins
pubmed
26148048
uniprot
proteins
sequence_length
313
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:11747454}; Lipid-anchor, GPI-anchor {ECO:0000305|PubMed:11747454}. Secreted {ECO:0000269|PubMed:11313366, ECO:0000269|PubMed:16531507, ECO:0000305|PubMed:11747454}. Note=Enriched in lipid rafts. {ECO:0000250|UniProtKB:O88310}.
uniprot
proteins