Mettl23
entrez
74319
canonical
uniprot
A2AA28
canonical
ensembl
ENSMUSG00000090266
resolver
ensp
ENSMUSP00000101978
resolver
enst
ENSMUST00000106370
resolver
genesymbol
Mettl23
resolver
uniprot
Q8R2Z2
resolver
uniprot
Q9D1J5
resolver
uniprot_entry
MET23_MOUSE
resolver
uniprot_sec
Q8R2Z2
resolver
uniprot_sec
Q9D1J5
resolver
amino_acid_sequence
MDSVRPRAPWAPPPDPASLDSPTCEPGLMAGTQLFRFREEPVPGGNRAVLEVRVPQVLHVQYGMYVWPCAVVLAQYLWFHRRSLPGKAVLEVGAGVSLPGILAAKCGAKVILSDSSEFPHCLDICRQSCQMNNLPQVEVVGLTWGHISKDILSLPPQDIILGSDVFFEPEDFESILATVYFLMQKNPKVQFWSTYQVRSADWSLEGLLYKWDMKCVHIPLESFDADKEDIAESTLPGRHTVEMLIISFAKDSF
uniprot
proteins
ec_number
2.1.1.319
uniprot
proteins
function
FUNCTION: Histone methyltransferase that dimethylates histone H3 at 'Arg-17', forming asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling (PubMed:28930672). Maternal factor involved in epigenetic chromatin reprogramming of the paternal genome in the zygote: mediates H3R17me2a, promoting histone H3.3 incorporation in the male pronucleus, leading to TET3 recruitment and subsequent DNA demethylation (PubMed:28930672). {ECO:0000269|PubMed:28930672}.
uniprot
proteins
mass_dalton
28289
uniprot
proteins
protein_family
METTL23 family
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
28930672
uniprot
proteins
sequence_length
253
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:28930672}. Cytoplasm {ECO:0000269|PubMed:28930672}. Note=Localizes in male and female zygote pronucleus and cytoplasm. {ECO:0000269|PubMed:28930672}.
uniprot
proteins