Phka1
entrez
18679
canonical
uniprot
P18826
canonical
ensembl
ENSMUSG00000034055
resolver
ensp
ENSMUSP00000042778
resolver
ensp
ENSMUSP00000061991
resolver
ensp
ENSMUSP00000184028
resolver
ensp
ENSMUSP00000184029
resolver
ensp
ENSMUSP00000184031
resolver
ensp
ENSMUSP00000184033
resolver
enst
ENSMUST00000043596
resolver
genesymbol
Phka1
resolver
uniprot
A2AI90
resolver
uniprot
A2AI91
resolver
uniprot
Q3TQJ0
resolver
uniprot
Q3UV91
resolver
uniprot
Q8CBA7
resolver
uniprot_entry
A2AI91_MOUSE
resolver
uniprot_entry
KPB1_MOUSE
resolver
uniprot_entry
Q3TQJ0_MOUSE
resolver
uniprot_entry
Q3UV91_MOUSE
resolver
uniprot_entry
Q8CBA7_MOUSE
resolver
uniprot_sec
A2AI90
resolver
activity_regulation
ACTIVITY REGULATION: By phosphorylation of various serine residues and by calcium.
uniprot
proteins
amino_acid_sequence
MRSRSNSGVRLDGYARLVHQTILCHQNPVTGLLPASYDQKDAWVRDNVYSILAVWGLGLAYRKNADRDEDKAKAYELEQSVVKLMRGLLHCMIRQVDKVESFKYSQSTKDSLHAKYNTKTCATVVGDDQWGHLQLDATSVYLLFLAQMTASGLHIIHSLDEVNFIQNLVFYIEAAYKTADFGIWERGDKTNQGISELNASSVGMAKAALEALDELDLFGVKGGPQSVIHVLADEVQHCQSILNSLLPRASTSKEVDASLLSVVSFPAFAVEDSHLVELTKQEIITKLQGRYGCCRFLRDGYKTPKEDPNRLYYEPAELKLFENIECEWPLFWTYFILDGIFSGNVEQVQEYREALDAVLIKGKNGVPLLPELYSVPPDRVDEEYQNPHTVDRVPMGKLPHMWGQSLYILGSLMAEGFLAPGEIDPLNRRFSTVPKPDVVVQVSILAETEEIKAILKDKGIDVETIAEVYPIRVQPARILSHIYSSLGCNSRMKLSGRPYRLMGVLGTSKLYDIRKTIFTFTPQFIDQQQFYLALDNQMIVEMLRTDLSYLCSRWRMTGQPTITFPISHTMLDEDGTSLNSSILAALRKMQDGYFGGARIQTGKLSEFLTTSCCTHLSFMDPGPEGKLYSEDYDEDYEDDLDSGNWMDSYDSTSNARCGDEVARYLDRLLAHTVPHPKLAPTSRKGGLDRFRAAVQTTCDLMSLVAKAKELHIQNVHMYLPTKLFQPSRPSLNLLDSPESPQDSQVPSVHVEVHLPRDQSGEVDFQSLVSQLKETSSLQEQADILYMLYSMKGPDWNTELYEEGGATVRELLSELYVKVGEIRHWGLIRYISGILRKKVEALDEACTDLLSYQKHLTVGLPPEPREKTISAPLPYEALTKLIDEASEGDMSISTLTQEIMVYLAMYMRTQPGLFAEMFRLRIGLIIQVMATELAHSLRCSAEEATEGLMNLSPSAMKNLLHHILSGKEFGVERSVRPTDSNVSPAISIHEIGAVGATKTERTGIMQLKSEIKQVEFRRLSVSMESQTSGGHPSGVDLMSPSFLSPAACIAASSGSFPTVCDHQTSKDSRQGQWQRRRRLDGALNRVPIGFYQKVWKILQKCHGLSVEGFVLPSSTTREMTPGEIKFSVHVESVLNRVPQPEYRQLLVEAILVLTMLADIEIHSIGSIIAVEKIVHIANDLFLQEQKTLGADDTMLAKDPASGICTLLYDSAPSGRFGTMTYLSKAAATYVQEFLPHSLCAMQ
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Phka1 are the cause of phosphorylase kinase deficiency in I-strain mice. {ECO:0000269|PubMed:8298647}.
uniprot
proteins
function
FUNCTION: Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin.
uniprot
proteins
mass_dalton
138825
uniprot
proteins
pathway_participation
PATHWAY: Glycan biosynthesis; glycogen metabolism.
uniprot
proteins
post_translational_modification
PTM: Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated. {ECO:0000250|UniProtKB:P18688}.
uniprot
proteins
protein_family
Phosphorylase b kinase regulatory chain family
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2602386
uniprot
proteins
pubmed
8298647
uniprot
proteins
sequence_length
1241
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
uniprot
proteins