AMDHD1
entrez
144193
canonical
uniprot
Q96NU7
canonical
ensembl
ENSG00000139344
resolver
ensp
ENSP00000266736
resolver
enst
ENST00000266736
resolver
genesymbol
AMDHD1
resolver
hgnc
HGNC:28577
resolver
uniprot
A8K463
resolver
uniprot
B3KVC5
resolver
uniprot
Q68CI8
resolver
uniprot_entry
B3KVC5_HUMAN
resolver
uniprot_entry
HUTI_HUMAN
resolver
uniprot_sec
A8K463
resolver
uniprot_sec
Q68CI8
resolver
amino_acid_sequence
MASGHSLLLENAQQVVLVCARGERFLARDALRSLAVLEGASLVVGKDGFIKAIGPADVIQRQFSGETFEEIIDCSGKCILPGLVDAHTHPVWAGERVHEFAMKLAGATYMEIHQAGGGIHFTVERTRQATEEELFRSLQQRLQCMMRAGTTLVECKSGYGLDLETELKMLRVIERARRELDIGISATYCGAHSVPKGKTATEAADDIINNHLPKLKELGRNGEIHVDNIDVFCEKGVFDLDSTRRILQRGKDIGLQINFHGDELHPMKAAELGAELGAQAISHLEEVSDEGIVAMATARCSAILLPTTAYMLRLKQPRARKMLDEGVIVALGSDFNPNAYCFSMPMVMHLACVNMRMSMPEALAAATINAAYALGKSHTHGSLEVGKQGDLIIINSSRWEHLIYQFGGHHELIEYVIAKGKLIYKT
uniprot
proteins
ec_number
3.5.2.7
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to form N-formimidoyl-L-glutamate. This reaction represents the third step of the universal histidine degradation pathway. In addition to its metabolic role, functions as a tumor suppressor by promoting TGF-beta signaling. Mechanistically, inhibits ubiquitination and proteasomal degradation of SMAD4, thereby stabilizing the protein. Enhances SMAD2/3 phosphorylation and increases TGF-beta-dependent transcriptional responses. Consequently, promotes apoptosis and induces cell cycle arrest in tumor cells (PubMed:39143229). {ECO:0000250|UniProtKB:P42084, ECO:0000269|PubMed:39143229}.
uniprot
proteins
mass_dalton
46743
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid degradation; L-histidine degradation into L-glutamate; N-formimidoyl-L-glutamate from L-histidine: step 3/3. {ECO:0000250|UniProtKB:P42084}.
uniprot
proteins
protein_family
HutI family
uniprot
proteins
protein_family
Metallo-dependent hydrolases superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15221005
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
39143229
uniprot
proteins
sequence_length
426
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:39143229}.
uniprot
proteins