Sycp3
entrez
20962
canonical
uniprot
P70281
canonical
ensembl
ENSMUSG00000020059
resolver
ensp
ENSMUSP00000020252
resolver
enst
ENSMUST00000020252
resolver
genesymbol
Sycp3
resolver
genesymbol_syn
Scp3
resolver
uniprot
A2RSE7
resolver
uniprot
F6Z6U2
resolver
uniprot
Q3V2A4
resolver
uniprot
Q549A7
resolver
uniprot_entry
A2RSE7_MOUSE
resolver
uniprot_entry
F6Z6U2_MOUSE
resolver
uniprot_entry
SYCP3_MOUSE
resolver
uniprot_sec
Q3V2A4
resolver
uniprot_sec
Q549A7
resolver
amino_acid_sequence
MLRGCGDSDSSPEPLSKHLKMVPGGRKHSGKSGKPPLVDQPKKAFDFEKDDKDLSGSEEDVADEKAPVIDKHGKKRSAGIIEDVGGEVQNMLEKFGADINKALLAKRKRIEMYTKASFKASNQKIEQIWKTQQEEIQKLNNEYSQQFMNVLQQWELDIQKFEEQGEKLSNLFRQQQKIFQQSRIVQSQRMFAMKQIHEQFIKSLEDVEKNNDNLFTGTQSELKKEMAMLQKKVMMETQQQEMANVRKSLQSMLF
uniprot
proteins
function
FUNCTION: Component of the synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase (PubMed:11311943, PubMed:22761579). Required for centromere pairing during meiosis in male germ cells (PubMed:22761579). Required for normal meiosis during spermatogenesis and male fertility (PubMed:10678170). Plays a lesser role in female fertility (PubMed:10678170, PubMed:12004129). Required for efficient phosphorylation of HORMAD1 and HORMAD2 (PubMed:22346761). {ECO:0000269|PubMed:10678170, ECO:0000269|PubMed:11311943, ECO:0000269|PubMed:12004129, ECO:0000269|PubMed:22346761, ECO:0000269|PubMed:22761579}.
uniprot
proteins
mass_dalton
29347
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000269|PubMed:22346761}.; PTM: Ubiquitinated by the SCF(Fbxw24) complex, leading to its degradation by the proteasome. {ECO:0000269|PubMed:35858239}.
uniprot
proteins
protein_family
XLR/SYCP3 family
uniprot
proteins
pubmed
10678170
uniprot
proteins
pubmed
11311943
uniprot
proteins
pubmed
12004129
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16717126
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22346761
uniprot
proteins
pubmed
22761579
uniprot
proteins
pubmed
24287868
uniprot
proteins
pubmed
27932493
uniprot
proteins
pubmed
30272023
uniprot
proteins
pubmed
30746471
uniprot
proteins
pubmed
30949703
uniprot
proteins
pubmed
35858239
uniprot
proteins
pubmed
9133341
uniprot
proteins
sequence_length
254
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:16717126}. Chromosome {ECO:0000269|PubMed:16717126, ECO:0000269|PubMed:22346761, ECO:0000269|PubMed:22761579, ECO:0000269|PubMed:24287868, ECO:0000269|PubMed:30272023, ECO:0000269|PubMed:30746471, ECO:0000269|PubMed:30949703}. Chromosome, centromere {ECO:0000269|PubMed:22761579}. Note=It is present in early unpaired cores, in the lateral domains of the synaptonemal complex and in the chromosome cores when they separate at diplotene. It is found axial to the metaphase I chromosomes and in association with pairs of sister centromeres. The centromere-associated protein becomes dissociated from the centromeres at anaphase II and is not found in mitotic metaphase centromeres (By similarity). The phosphorylated form localizes preferentially to unsynapsed chromosomal regions (PubMed:22346761). {ECO:0000250|UniProtKB:Q60547, ECO:0000269|PubMed:22346761}.
uniprot
proteins