Klf2
entrez
16598
canonical
uniprot
Q60843
canonical
ensembl
ENSMUSG00000055148
resolver
ensp
ENSMUSP00000064823
resolver
enst
ENSMUST00000067912
resolver
genesymbol
Klf2
resolver
genesymbol_syn
Lklf
resolver
uniprot
B2RS60
resolver
uniprot
Q3V293
resolver
uniprot_entry
KLF2_MOUSE
resolver
uniprot_entry
Q3V293_MOUSE
resolver
uniprot_sec
B2RS60
resolver
amino_acid_sequence
MALSEPILPSFATFASPCERGLQERWPRNEPEAGGTDEDLNNVLDFILSMGLDGLGAENPPEPPPQPPPPAFYYPEPGAPPPYSIPAASLGTELLRPDLDPPQGPALHGRFLLAPPGRLVKAEPPEVDGGGYGCAPGLAHGPRGLKLEGAPGATGACMRGPAGRPPPPPDTPPLSPDGPLRIPASGPRNPFPPPFGPGPSFGGPGPALHYGPPAPGAFGLFEDAAAAAAALGLAPPATRGLLTPPSSPLELLEAKPKRGRRSWPRKRAATHTCSYTNCGKTYTKSSHLKAHLRTHTGEKPYHCNWEGCGWKFARSDELTRHYRKHTGHRPFQCHLCDRAFSRSDHLALHMKRHM
uniprot
proteins
function
FUNCTION: Transcription factor that binds to the CACCC box in the promoter of target genes such as HBB/beta globin or NOV and activates their transcription. Might be involved in transcriptional regulation by modulating the binding of the RARA nuclear receptor to RARE DNA elements (By similarity). {ECO:0000250|UniProtKB:Q9Y5W3}.
uniprot
proteins
mass_dalton
37657
uniprot
proteins
mutagenesis
MUTAGEN 121; /note="K->R: Greatly impairs polyubiquitination. Abolishes polyubiquitination; when associated with R-146."; /evidence="ECO:0000269|PubMed:15003522"; MUTAGEN 146; /note="K->R: Abolishes polyubiquitination; when associated with R-121."; /evidence="ECO:0000269|PubMed:15003522
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein. {ECO:0000269|PubMed:15003522}.
uniprot
proteins
protein_family
Krueppel C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
11375995
uniprot
proteins
pubmed
15003522
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7565748
uniprot
proteins
sequence_length
354
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
uniprot
proteins