Rhbg
entrez
58176
canonical
uniprot
Q8BUX5
canonical
ensembl
ENSMUSG00000104445
resolver
ensp
ENSMUSP00000130767
resolver
ensp
ENSMUSP00000186127
resolver
enst
ENSMUST00000171887
resolver
genesymbol
Rhbg
resolver
uniprot
Q9QXP1
resolver
uniprot_entry
RHBG_MOUSE
resolver
uniprot_sec
Q9QXP1
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by amiloride. {ECO:0000269|PubMed:20592240}.
uniprot
proteins
amino_acid_sequence
MARVPRHRRLVLPLLCLLFQGATALLFAIFVRYNHETDAALWHWGNHSNVDNEFYFRYPSFQDVHVMVFVGFGFLMVFLQRYGFSSVGFTFLVASLTLQWATLLQGFLHSFHGGHIHVGVESLINADFCAGAVLISFGAVLGKTGPAQLLLMALLEAVLFSVNEFILLSLLGVRDAGGSMTIHTFGAYFGLFLSWVLYRSQLEKSRHRQSSVYNSDLFAMIGTIFLWVFWPSFNSAPTALGDGQHRTVVNTYYSLTASTLSTFALSALVSGDGRLDMVHVQNAALAGGVVVGTSSEMMLTPFGALAAGFLAGTVSTLGYKFFTPILESRFKLQDTCGVHNLHGMPGVLGAILGVVVAALATHEAYGDGLQSVFPLIAKGQRSATSQAVYQLFGMFVTLVFASVGGSLGGLLLRLPFLDSPPDSQCFEDQVYWEVPGEQETETQRPLRGGESDTRA
uniprot
proteins
function
FUNCTION: Ammonium transporter involved in the maintenance of acid-base homeostasis. Transports ammonium and its related derivative methylammonium across the basolateral plasma membrane of epithelial cells likely contributing to renal transepithelial ammonia transport and ammonia metabolism. May transport either NH4(+) or NH3 ammonia species predominantly mediating an electrogenic NH4(+) transport (By similarity) (PubMed:15353405, PubMed:16131648, PubMed:20592240, PubMed:27681563). May act as a CO2 channel providing for renal acid secretion (By similarity). {ECO:0000250|UniProtKB:Q9H310, ECO:0000269|PubMed:15353405, ECO:0000269|PubMed:16131648, ECO:0000269|PubMed:20592240, ECO:0000269|PubMed:27681563}.
uniprot
proteins
mass_dalton
49543
uniprot
proteins
mutagenesis
MUTAGEN 128; /note="F->L: Normal plasma membrane localization."; /evidence="ECO:0000269|PubMed:27681563"; MUTAGEN 183; /note="H->A,L,D: Impairs targeting to plasma membrane resulting in loss of transporter activity."; /evidence="ECO:0000269|PubMed:27681563"; MUTAGEN 230; /note="W->A,F,L: Normal plasma membrane localization. Loss of transporter activity."; /evidence="ECO:0000269|PubMed:27681563"; MUTAGEN 342; /note="H->L: Decreases expression and/or localization at the plasma membrane."; /evidence="ECO:0000269|PubMed:27681563
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:11024028}.
uniprot
proteins
protein_family
Ammonium transporter (TC 2.A.49) family
uniprot
proteins
protein_family
Rh subfamily
uniprot
proteins
pubmed
11024028
uniprot
proteins
pubmed
12388412
uniprot
proteins
pubmed
12730882
uniprot
proteins
pubmed
15353405
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15576624
uniprot
proteins
pubmed
16131648
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20592240
uniprot
proteins
pubmed
27681563
uniprot
proteins
sequence_length
455
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:27681563}; Multi-pass membrane protein {ECO:0000255}. Basolateral cell membrane {ECO:0000250|UniProtKB:Q9H310}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 11..31; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 59..79; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 84..104; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 122..142; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 147..167; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 176..198; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 217..237; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 249..269; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 280..300; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 302..322; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 344..364; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 391..411; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins