Hamp
entrez
84506
canonical
uniprot
Q9EQ21
canonical
ensembl
ENSMUSG00000050440
resolver
ensp
ENSMUSP00000055404
resolver
enst
ENSMUST00000062620
resolver
genesymbol
Hamp
resolver
genesymbol_syn
Hamp1
resolver
genesymbol_syn
Hepc
resolver
genesymbol_syn
Hepc1
resolver
uniprot_entry
HEPC_MOUSE
resolver
amino_acid_sequence
MALSTRTQAACLLLLLLASLSSTTYLHQQMRQTTELQPLHGEESRADIAIPMQKRRKRDTNFPICIFCCKCCNNSQCGICCKT
uniprot
proteins
function
FUNCTION: Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes. {ECO:0000269|PubMed:11447267, ECO:0000269|PubMed:24880340}.
uniprot
proteins
mass_dalton
9352
uniprot
proteins
protein_family
Hepcidin family
uniprot
proteins
pubmed
11113132
uniprot
proteins
pubmed
11447267
uniprot
proteins
pubmed
12370282
uniprot
proteins
pubmed
12729891
uniprot
proteins
pubmed
15124018
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24880340
uniprot
proteins
sequence_length
83
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11113132, ECO:0000269|PubMed:15124018}.
uniprot
proteins