Ppa1
entrez
67895
canonical
uniprot
Q9D819
canonical
ensembl
ENSMUSG00000020089
resolver
ensp
ENSMUSP00000020286
resolver
enst
ENSMUST00000020286
resolver
genesymbol
Ppa1
resolver
genesymbol_syn
Pp
resolver
genesymbol_syn
Pyp
resolver
uniprot
Q4FK49
resolver
uniprot_entry
IPYR_MOUSE
resolver
uniprot_entry
Q4FK49_MOUSE
resolver
amino_acid_sequence
MSGFSSEERAAPFTLEYRVFLKNEKGQYISPFHDVPIYADKDVFHMVVEVPRWSNAKMEIATKDPLNPIKQDVKKGKLRYVANLFPYKGYIWNYGAIPQTWEDPGHSDKHTGCCGDNDPIDVCEIGSKVCARGEIIRVKVLGILAMIDEGETDWKVIAINVDDPDAANYKDISDVERLKPGYLEATVDWFRRYKVPDGKPENEFAFNAEFKNKDFAVDIIKSTHDYWKALVTKKTDGKGISCMNTTVSESPFKCDPDAAKAIVDALPPPCESACSLPTDVDKWFHQQKN
uniprot
proteins
ec_number
3.6.1.1
uniprot
proteins
function
FUNCTION: Catalyzes the hydrolysis of inorganic diphosphate into two phosphate molecules (PubMed:24271717). Has MAP kinase serine/threonine phosphatase activity toward c-Jun N-terminal kinase (JNK) and, in neuronal cells, is involved in the negative regulation of neurite growth via JNK dephosphorylation (PubMed:23626709). {ECO:0000269|PubMed:23626709, ECO:0000269|PubMed:24271717}.
uniprot
proteins
mass_dalton
32667
uniprot
proteins
mutagenesis
MUTAGEN 118; /note="D->A: Loss of inorganic diphosphate phosphatase activity. Loss of MAP kinase serine/threonine phosphatase activity toward JNK. Unable to inhibit neurite growth."; /evidence="ECO:0000269|PubMed:23626709
uniprot
proteins
protein_family
PPase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23626709
uniprot
proteins
pubmed
24271717
uniprot
proteins
sequence_length
289
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins