SDHAF4
entrez
135154
canonical
uniprot
Q5VUM1
canonical
ensembl
ENSG00000154079
resolver
ensp
ENSP00000359505
resolver
ensp
ENSP00000790998
resolver
enst
ENST00000370474
resolver
genesymbol
SDHAF4
resolver
genesymbol_syn
C6orf57
resolver
hgnc
HGNC:20957
resolver
uniprot
E1P532
resolver
uniprot_entry
SDHF4_HUMAN
resolver
uniprot_sec
E1P532
resolver
amino_acid_sequence
MTPSRLPWLLSWVSATAWRAARSPLLCHSLRKTSSSQGGKSELVKQSLKKPKLPEGRFDAPEDSHLEKEPLEKFPDDVNPVTKEKGGPRGPEPTRYGDWERKGRCIDF
uniprot
proteins
function
FUNCTION: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol (PubMed:24954416). Binds to the flavoprotein subunit SDHA in its FAD-bound form, blocking the generation of excess reactive oxygen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit SDHB into the SDH catalytic dimer (By similarity). {ECO:0000250|UniProtKB:P38345, ECO:0000269|PubMed:24954416}.
uniprot
proteins
mass_dalton
12213
uniprot
proteins
protein_family
SDHAF4 family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
24954416
uniprot
proteins
sequence_length
108
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250|UniProtKB:P38345}.
uniprot
proteins