Fbxo3
entrez
57443
canonical
uniprot
Q9DC63
canonical
ensembl
ENSMUSG00000027180
resolver
ensp
ENSMUSP00000028603
resolver
ensp
ENSMUSP00000099625
resolver
ensp
ENSMUSP00000106766
resolver
ensp
ENSMUSP00000289876
resolver
ensp
ENSMUSP00000289884
resolver
ensp
ENSMUSP00000289889
resolver
enst
ENSMUST00000111136
resolver
genesymbol
Fbxo3
resolver
genesymbol_syn
Fba
resolver
genesymbol_syn
Fbx3
resolver
uniprot
A2BHN5
resolver
uniprot
A2BHN6
resolver
uniprot
A2BHN7
resolver
uniprot
Q3TKB0
resolver
uniprot
Q3U9C1
resolver
uniprot
Q8C7I0
resolver
uniprot
Q8CDU1
resolver
uniprot
Q8CEJ0
resolver
uniprot
Q91VI9
resolver
uniprot
Q9CVV6
resolver
uniprot
Q9D2J5
resolver
uniprot
Q9JIE4
resolver
uniprot_entry
A2BHN6_MOUSE
resolver
uniprot_entry
FBX3_MOUSE
resolver
uniprot_entry
Q8CDU1_MOUSE
resolver
uniprot_entry
Q9CVV6_MOUSE
resolver
uniprot_sec
A2BHN5
resolver
uniprot_sec
A2BHN7
resolver
uniprot_sec
Q3TKB0
resolver
uniprot_sec
Q3U9C1
resolver
uniprot_sec
Q8C7I0
resolver
uniprot_sec
Q8CEJ0
resolver
uniprot_sec
Q91VI9
resolver
uniprot_sec
Q9D2J5
resolver
uniprot_sec
Q9JIE4
resolver
amino_acid_sequence
MAAVEAETGLLTLESLPTDPLLLILSFVDYRDLINCCYVSRRLSQLSTHDPLWRRHCKKYWLISEEEKAGKSQCWRSLFIETYSDVGRYIDHYAAIKKAWRDLKKYLEPRCPRMVLSLKEGAREEDLDAVEAQIGCKLPDDYRCSYRIHNGQKLVVPGLLGSMALSNHYRSEDLLDVDTAAGGFQQRQGLKYCLPLTFCIHTGLSQYIAVEAAEGRNKNEVFYQCPDQMARNPAAIDMFIIGATFTDWFTSYVNNVVSGGFPIIRDQIFRYIHDPECVATTGDITVSVSTSFLPELSSVHPPHYFFTYRIRIEMSRDALPEKACQLDSRYWRITNAKGDVEEVQGPGVVGEFPIISPGRIYEYTSCTTFSTTSGYMEGYYTFHFLYFKDKVFNVAIPRFHMACPTFRVSIARLEMGPDEYEEMEEEAEEEEEEENDDSADMDESDESDADENESDEGEGEARRRRVFDVPIRRRRCSRLF
uniprot
proteins
function
FUNCTION: Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex, SCF(FBXO3), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome (By similarity). In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented (By similarity). PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation (By similarity). The SCF(FBXO3) also acts as a regulator of inflammation by mediating ubiquitination and degradation of FBXL2: specifically recognizes FBXL2 phosphorylated at 'Thr-404' and promotes its ubiquitination (PubMed:23542741). {ECO:0000250|UniProtKB:Q9UK99, ECO:0000269|PubMed:23542741}.
uniprot
proteins
mass_dalton
55227
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:23542741}.
uniprot
proteins
pubmed
10945468
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23542741
uniprot
proteins
sequence_length
480
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UK99}. Note=Colocalizes with PML at the peripheries of nuclear bodies. {ECO:0000250|UniProtKB:Q9UK99}.
uniprot
proteins