Anapc10
entrez
68999
canonical
uniprot
Q8K2H6
canonical
ensembl
ENSMUSG00000036977
resolver
ensp
ENSMUSP00000048244
resolver
ensp
ENSMUSP00000148220
resolver
ensp
ENSMUSP00000274287
resolver
ensp
ENSMUSP00000274289
resolver
ensp
ENSMUSP00000274290
resolver
ensp
ENSMUSP00000274297
resolver
ensp
ENSMUSP00000274299
resolver
ensp
ENSMUSP00000274300
resolver
ensp
ENSMUSP00000345535
resolver
ensp
ENSMUSP00000345536
resolver
ensp
ENSMUSP00000345537
resolver
ensp
ENSMUSP00000345543
resolver
enst
ENSMUST00000048147
resolver
enst
ENSMUST00000210812
resolver
genesymbol
Anapc10
resolver
genesymbol_syn
Apc10
resolver
uniprot
Q9CW24
resolver
uniprot_entry
APC10_MOUSE
resolver
uniprot_sec
Q9CW24
resolver
amino_acid_sequence
MTTPNKTPPGADPKQLERTATVREIGSQAVWSLSSCKPGFGVDQLRDDNLETYWQSDGSQPHLVNIQFRRKTTVKTLCIYADYKSDESYTPSKISVRVGNNFHNLQEIRQLELVEPSGWIHVPLTDNHKKPTRTFMIQIAVLANHQNGRDTHMRQIKIYTPVEESSIGKFPRCTTIDFMMYRSIR
uniprot
proteins
function
FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (By similarity). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (By similarity). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (By similarity). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (By similarity). {ECO:0000250|UniProtKB:Q9UM13}.
uniprot
proteins
mass_dalton
21266
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9UM13}.
uniprot
proteins
protein_family
APC10 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23328397
uniprot
proteins
pubmed
23806337
uniprot
proteins
sequence_length
185
uniprot
proteins