Crcp
entrez
12909
canonical
uniprot
O35427
canonical
ensembl
ENSMUSG00000025532
resolver
ensp
ENSMUSP00000026608
resolver
enst
ENSMUST00000026608
resolver
genesymbol
Crcp
resolver
uniprot_entry
RPC9_MOUSE
resolver
amino_acid_sequence
MEVKDANAALLSNYEVFQLLTDLKEQRKESGKNKHSAGQQNLNAITYETLKYISKTPCRNQSPAIVQEFLTAMKSHKLTKAEKLQLLNHRPMTAVEIQLMVEESEERLTEEQIEALLHTVTSILPAGPEDEQSKSTSNDVAMEEEEPA
uniprot
proteins
function
FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity). Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. With POLR3H/RPC8 forms a mobile stalk that protrudes from Pol III core and functions primarily in transcription initiation (By similarity). Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (By similarity). {ECO:0000250|UniProtKB:O75575, ECO:0000250|UniProtKB:Q9C0Z9}.; FUNCTION: Accessory protein for the calcitonin gene-related peptide (CGRP) receptor. It modulates CGRP responsiveness in a variety of tissues. {ECO:0000269|PubMed:10903324}.
uniprot
proteins
mass_dalton
16683
uniprot
proteins
protein_family
Eukaryotic RPC9 RNA polymerase subunit family
uniprot
proteins
pubmed
10067875
uniprot
proteins
pubmed
10903324
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
9322931
uniprot
proteins
sequence_length
148
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O75575}. Cell membrane {ECO:0000269|PubMed:10903324}; Peripheral membrane protein {ECO:0000269|PubMed:10903324}; Cytoplasmic side {ECO:0000269|PubMed:10903324}.
uniprot
proteins