TJP1
entrez
7082
canonical
uniprot
Q07157
canonical
ensembl
ENSG00000104067
resolver
ensembl
ENSG00000277401
resolver
ensp
ENSP00000281537
resolver
ensp
ENSP00000348416
resolver
ensp
ENSP00000382890
resolver
ensp
ENSP00000441202
resolver
ensp
ENSP00000481375
resolver
ensp
ENSP00000482697
resolver
ensp
ENSP00000483470
resolver
ensp
ENSP00000484535
resolver
ensp
ENSP00000504775
resolver
ensp
ENSP00000604451
resolver
ensp
ENSP00000604453
resolver
ensp
ENSP00000752692
resolver
enst
ENST00000356107
resolver
enst
ENST00000400011
resolver
enst
ENST00000612628
resolver
enst
ENST00000613680
resolver
enst
ENST00000614355
resolver
enst
ENST00000621049
resolver
enst
ENST00000677774
resolver
genesymbol
TJP1
resolver
genesymbol_syn
ZO1
resolver
hgnc
HGNC:11827
resolver
uniprot
A0A087X0K9
resolver
uniprot
A0A0G2JNH2
resolver
uniprot
A0A7I2V5U5
resolver
uniprot
A9CQZ8
resolver
uniprot
B4DZK4
resolver
uniprot
B4E3K1
resolver
uniprot
G3V1L9
resolver
uniprot
G5E9E7
resolver
uniprot
Q2NKP3
resolver
uniprot
Q4ZGJ6
resolver
uniprot_entry
A0A087X0K9_HUMAN
resolver
uniprot_entry
A0A0G2JNH2_HUMAN
resolver
uniprot_entry
A0A7I2V5U5_HUMAN
resolver
uniprot_entry
A9CQZ8_HUMAN
resolver
uniprot_entry
B4DZK4_HUMAN
resolver
uniprot_entry
G3V1L9_HUMAN
resolver
uniprot_entry
G5E9E7_HUMAN
resolver
uniprot_entry
ZO1_HUMAN
resolver
uniprot_sec
B4E3K1
resolver
uniprot_sec
Q2NKP3
resolver
uniprot_sec
Q4ZGJ6
resolver
amino_acid_sequence
MSARAAAAKSTAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSPQAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETNPASSTSAVNHNVNLTNVRLEEPTPAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSSHVDPTKVYRKDPYPEEMMRQNHVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRDLEQPTYRYESSSYTDQFSRNYEHRLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSYDSRPRYEQAPRASALRHEEQPAPGYDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAAVPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKRSASLETKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHDKTLYRIPEPQKPQLKPPEDIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHLSEPAKPAHSQNQSNFSSYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQPVTSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYPQKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETAHKPDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCDPKTWQNKCLPGDPNYLVGANCVSVLIDHF
uniprot
proteins
function
FUNCTION: TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). Forms a multistranded TJP1/ZO1 condensate which elongates to form a tight junction belt, the belt is anchored at the apical cell membrane via interaction with PATJ (By similarity). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates in the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). May play a role in mediating cell morphology changes during ameloblast differentiation via its role in tight junctions (By similarity). {ECO:0000250|UniProtKB:O97758, ECO:0000250|UniProtKB:P39447, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:21240187}.
uniprot
proteins
mass_dalton
195459
uniprot
proteins
mutagenesis
MUTAGEN 201; /note="R->A: Strongly reduced interaction with GJA1."; /evidence="ECO:0000269|PubMed:18636092"; MUTAGEN 209; /note="K->A: Abolishes interaction with GJA1."; /evidence="ECO:0000269|PubMed:18636092"; MUTAGEN 1699..1700; /note="MC->AA: Abolishes interaction with CDC42BPB."; /evidence="ECO:0000269|PubMed:21240187"; MUTAGEN 1748; /note="Missing: Abolishes interaction with CDC42BPB and MYZAP."; /evidence="ECO:0000269|PubMed:21240187
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at tyrosine redidues in response to epidermal growth factor (EGF) (PubMed:19332538, PubMed:7542259). This response is dependent on an intact actin microfilament system (PubMed:7542259). Dephosphorylated by PTPRJ (PubMed:19332538). {ECO:0000269|PubMed:19332538, ECO:0000269|PubMed:7542259}.
uniprot
proteins
protein_family
MAGUK family
uniprot
proteins
pubmed
11734628
uniprot
proteins
pubmed
12023291
uniprot
proteins
pubmed
12154091
uniprot
proteins
pubmed
12354695
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15183511
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
16737969
uniprot
proteins
pubmed
17015620
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17897942
uniprot
proteins
pubmed
17928286
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18636092
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18823282
uniprot
proteins
pubmed
19332538
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20093627
uniprot
proteins
pubmed
20200156
uniprot
proteins
pubmed
20930113
uniprot
proteins
pubmed
21240187
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21387411
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22016770
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28169360
uniprot
proteins
pubmed
31473225
uniprot
proteins
pubmed
7542259
uniprot
proteins
pubmed
7798316
uniprot
proteins
pubmed
8395056
uniprot
proteins
pubmed
9792688
uniprot
proteins
sequence_length
1748
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7798316}; Peripheral membrane protein {ECO:0000269|PubMed:7798316}; Cytoplasmic side {ECO:0000269|PubMed:7798316}. Cell junction, tight junction {ECO:0000269|PubMed:7798316}. Cell junction {ECO:0000269|PubMed:28169360}. Cell junction, gap junction. Cell projection, podosome {ECO:0000269|PubMed:20930113}. Note=Moves from the cytoplasm to the cell membrane concurrently with cell-cell contact (PubMed:7798316). Forms a condensed tight junction-linked belt of protein during junction formation which becomes anchored to the apical cell membrane via interaction with PATJ (By similarity). At podosomal sites, is predominantly localized in the ring structure surrounding the actin core (PubMed:20930113). Colocalizes with SPEF1 at sites of cell-cell contact in intestinal epithelial cells (PubMed:31473225). {ECO:0000250|UniProtKB:O97758, ECO:0000269|PubMed:20930113, ECO:0000269|PubMed:31473225, ECO:0000269|PubMed:7798316}.
uniprot
proteins