SPATA22
entrez
84690
canonical
uniprot
Q8NHS9
canonical
ensembl
ENSG00000141255
resolver
ensp
ENSP00000268981
resolver
ensp
ENSP00000347541
resolver
ensp
ENSP00000380354
resolver
ensp
ENSP00000441920
resolver
ensp
ENSP00000459329
resolver
ensp
ENSP00000459580
resolver
ensp
ENSP00000460187
resolver
enst
ENST00000541913
resolver
genesymbol
SPATA22
resolver
hgnc
HGNC:30705
resolver
uniprot
A0A140VJV9
resolver
uniprot
B4DHW8
resolver
uniprot
B4DXB1
resolver
uniprot
D3DTI9
resolver
uniprot
F5GWB9
resolver
uniprot
J3KN63
resolver
uniprot
Q969H3
resolver
uniprot
Q96JT4
resolver
uniprot_entry
A0A140VJV9_HUMAN
resolver
uniprot_entry
B4DHW8_HUMAN
resolver
uniprot_entry
F5GWB9_HUMAN
resolver
uniprot_entry
SPT22_HUMAN
resolver
uniprot_sec
B4DXB1
resolver
uniprot_sec
D3DTI9
resolver
uniprot_sec
J3KN63
resolver
uniprot_sec
Q969H3
resolver
uniprot_sec
Q96JT4
resolver
amino_acid_sequence
MKRSLNENSARSTAGCLPVPLFNQKKRNRQPLTSNPLKDDSGISTPSDNYDFPPLPTDWAWEAVNPELAPVMKTVDTGQIPHSVSRPLRSQDSVFNSIQSNTGRSQGGWSYRDGNKNTSLKTWNKNDFKPQCKRTNLVANDGKNSCPVSSGAQQQKQLRIPEPPNLSRNKETELLRQTHSSKISGCTMRGLDKNSALQTLKPNFQQNQYKKQMLDDIPEDNTLKETSLYQLQFKEKASSLRIISAVIESMKYWREHAQKTVLLFEVLAVLDSAVTPGPYYSKTFLMRDGKNTLPCVFYEIDRELPRLIRGRVHRCVGNYDQKKNIFQCVSVRPASVSEQKTFQAFVKIADVEMQYYINVMNET
uniprot
proteins
disease_involvement
DISEASE: Spermatogenic failure 96 (SPGF96) [MIM:621001]: An autosomal recessive, male infertility disorder characterized by non-obstructive azoospermia due to spermatogenesis arrest at the zygotene stage. {ECO:0000269|PubMed:34392356, ECO:0000269|PubMed:35285020}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Premature ovarian failure 25 (POF25) [MIM:621002]: A form of premature ovarian failure, an ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. POF25 inheritance is autosomal recessive. {ECO:0000269|PubMed:35285020}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Meiosis-specific protein required for homologous recombination in meiosis I. {ECO:0000250|UniProtKB:Q5SV06}.
uniprot
proteins
mass_dalton
41318
uniprot
proteins
mutagenesis
MUTAGEN 86; /note="R->G: Loss of recruitment to DNA damage sites; when associated with G-136 and G-137."; /evidence="ECO:0000269|PubMed:40296718"; MUTAGEN 136; /note="N->G: Loss of recruitment to DNA damage sites; when associated with G-86 and G-137."; /evidence="ECO:0000269|PubMed:40296718"; MUTAGEN 137; /note="L->G: Loss of recruitment to DNA damage sites; when associated with G-86 and G-136."; /evidence="ECO:0000269|PubMed:40296718
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15713825
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
34392356
uniprot
proteins
pubmed
35285020
uniprot
proteins
pubmed
36331299
uniprot
proteins
pubmed
40296718
uniprot
proteins
sequence_length
363
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q5SV06}. Nucleus {ECO:0000269|PubMed:36331299}. Note=Localizes on meiotic chromosome axes. Accumulates on resected DNA. Localization is dependent on MEIOB. {ECO:0000250|UniProtKB:Q5SV06, ECO:0000269|PubMed:36331299}.
uniprot
proteins