SLC20A1
entrez
6574
canonical
uniprot
Q8WUM9
canonical
ensembl
ENSG00000144136
resolver
ensp
ENSP00000272542
resolver
ensp
ENSP00000592359
resolver
enst
ENST00000272542
resolver
enst
ENST00000922300
resolver
genesymbol
SLC20A1
resolver
genesymbol_syn
GLVR1
resolver
genesymbol_syn
PIT1
resolver
hgnc
HGNC:10946
resolver
uniprot
A7LNJ1
resolver
uniprot
Q08344
resolver
uniprot
Q6DHX8
resolver
uniprot
Q9UQ82
resolver
uniprot_entry
A7LNJ1_HUMAN
resolver
uniprot_entry
S20A1_HUMAN
resolver
uniprot_sec
Q08344
resolver
uniprot_sec
Q6DHX8
resolver
uniprot_sec
Q9UQ82
resolver
amino_acid_sequence
MATLITSTTAATAASGPLVDYLWMLILGFIIAFVLAFSVGANDVANSFGTAVGSGVVTLKQACILASIFETVGSVLLGAKVSETIRKGLIDVEMYNSTQGLLMAGSVSAMFGSAVWQLVASFLKLPISGTHCIVGATIGFSLVAKGQEGVKWSELIKIVMSWFVSPLLSGIMSGILFFLVRAFILHKADPVPNGLRALPVFYACTVGINLFSIMYTGAPLLGFDKLPLWGTILISVGCAVFCALIVWFFVCPRMKRKIEREIKCSPSESPLMEKKNSLKEDHEETKLSVGDIENKHPVSEVGPATVPLQAVVEERTVSFKLGDLEEAPERERLPSVDLKEETSIDSTVNGAVQLPNGNLVQFSQAVSNQINSSGHYQYHTVHKDSGLYKELLHKLHLAKVGDCMGDSGDKPLRRNNSYTSYTMAICGMPLDSFRAKEGEQKGEEMEKLTWPNADSKKRIRMDSYTSYCNAVSDLHSASEIDMSVKAEMGLGDRKGSNGSLEEWYDQDKPEVSLLFQFLQILTACFGSFAHGGNDVSNAIGPLVALYLVYDTGDVSSKVATPIWLLLYGGVGICVGLWVWGRRVIQTMGKDLTPITPSSGFSIELASALTVVIASNIGLPISTTHCKVGSVVSVGWLRSKKAVDWRLFRNIFMAWFVTVPISGVISAAIMAIFRYVILRM
uniprot
proteins
function
FUNCTION: Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion (PubMed:11009570, PubMed:16790504, PubMed:17494632, PubMed:19726692, PubMed:7929240, PubMed:8041748). May play a role in extracellular matrix and cartilage calcification as well as in vascular calcification (PubMed:11009570). Essential for cell proliferation but this function is independent of its phosphate transporter activity (PubMed:19726692). {ECO:0000269|PubMed:11009570, ECO:0000269|PubMed:16790504, ECO:0000269|PubMed:17494632, ECO:0000269|PubMed:19726692, ECO:0000269|PubMed:7929240, ECO:0000269|PubMed:8041748}.; FUNCTION: (Microbial infection) May function as a retroviral receptor as it confers human cells susceptibility to infection to Gibbon Ape Leukemia Virus (GaLV), Simian sarcoma-associated virus (SSAV) and Feline leukemia virus subgroup B (FeLV-B) as well as 10A1 murine leukemia virus (10A1 MLV). {ECO:0000269|PubMed:12097582, ECO:0000269|PubMed:1309898, ECO:0000269|PubMed:2078500, ECO:0000269|PubMed:7966619}.
uniprot
proteins
mass_dalton
73700
uniprot
proteins
mutagenesis
MUTAGEN 128; /note="S->A: Loss of sodium-dependent phosphate transporter activity. Able to restore cell proliferation in SLC20A1-deficient HeLa cells to a level identical to that observed in their wild-type counterpart. No effect on its localization to the cell membrane."; /evidence="ECO:0000269|PubMed:19726692"; MUTAGEN 550..558; /note="DTGDVSSKV->KQEASTKA: Loss of virus infectibility."; /evidence="ECO:0000269|PubMed:8411375"; MUTAGEN 550; /note="D->K: Drastic reduction of virus infectibility, but conserved virus binding ability."; /evidence="ECO:0000269|PubMed:12097582, ECO:0000269|PubMed:8411375"; MUTAGEN 550; /note="Missing: Loss of virus infectibility."; /evidence="ECO:0000269|PubMed:12097582, ECO:0000269|PubMed:8411375
uniprot
proteins
protein_family
Inorganic phosphate transporter (PiT) (TC 2.A.20) family
uniprot
proteins
pubmed
11009570
uniprot
proteins
pubmed
12097582
uniprot
proteins
pubmed
1309898
uniprot
proteins
pubmed
1531369
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15641067
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
16790504
uniprot
proteins
pubmed
17494632
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19726692
uniprot
proteins
pubmed
2078500
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
7929240
uniprot
proteins
pubmed
7966619
uniprot
proteins
pubmed
8041748
uniprot
proteins
pubmed
8411375
uniprot
proteins
pubmed
9889306
uniprot
proteins
sequence_length
679
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19726692}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..41; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 62..82; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 100..120; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 158..178; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 203..223; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 230..250; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 511..531; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 558..578; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 600..620; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 650..670; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins