Nek7
entrez
360850
canonical
uniprot
D3ZBE5
canonical
ensembl
ENSRNOG00000000657
resolver
ensembl
ENSRNOG00055000899
resolver
ensembl
ENSRNOG00060004647
resolver
ensembl
ENSRNOG00065021005
resolver
ensp
ENSRNOP00000000817
resolver
ensp
ENSRNOP00000093817
resolver
ensp
ENSRNOP00055001230
resolver
ensp
ENSRNOP00060005851
resolver
ensp
ENSRNOP00065028816
resolver
enst
ENSRNOT00000000817
resolver
enst
ENSRNOT00055001534
resolver
enst
ENSRNOT00060007788
resolver
enst
ENSRNOT00065035755
resolver
genesymbol
Nek7
resolver
uniprot_entry
NEK7_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Binding to NEK9 stimulates its activity by releasing the autoinhibitory function of Tyr-97. {ECO:0000250|UniProtKB:Q8TDX7}.
uniprot
proteins
amino_acid_sequence
MDEQPQGMQGPPVPQFQPQKALRPDMGYNTLANFRIEKKIGRGQFSEVYRASCLLDGVPVALKKVQIFDLMDAKARADCIKEIDLLKQLNHPNVIKYYASFIEDNELNIVLELADAGDLSRMIKHFKKQKRLIPERTVWKYFVQLCSALDHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSKTTAAHSLVGTPYYMSPERIHENGYNFKSDIWSLGCLLYEMAALQSPFYGDKMNLYSLCKKIEQCDYPPLPSDHYSEELRQLVNICINPDPEKRPDIAYVYDVAKRMHACTASS
uniprot
proteins
ec_number
2.7.11.34
uniprot
proteins
function
FUNCTION: Protein kinase which plays an important role in mitotic cell cycle progression (PubMed:11516946). Required for microtubule nucleation activity of the centrosome, robust mitotic spindle formation and cytokinesis (By similarity). Phosphorylates EML4 at 'Ser-146', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression (By similarity). Phosphorylates RPS6KB1 (PubMed:11516946). Acts as an essential activator of the NLRP3 inflammasome assembly independently of its kinase activity (By similarity). Acts by unlocking NLRP3 following NLRP3 tranlocation into the microtubule organizing center (MTOC), relieving NLRP3 autoinhibition and promoting formation of the NLRP3:PYCARD complex, and activation of CASP1 (By similarity). Serves as a cellular switch that enforces mutual exclusivity of the inflammasome response and cell division: interaction with NEK9 prevents interaction with NLRP3 and activation of the inflammasome during mitosis (By similarity). {ECO:0000250|UniProtKB:Q8TDX7, ECO:0000269|PubMed:11516946}.
uniprot
proteins
mass_dalton
34529
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-195 required for its activation. {ECO:0000250|UniProtKB:Q8TDX7}.
uniprot
proteins
protein_family
NEK Ser/Thr protein kinase family
uniprot
proteins
protein_family
NIMA subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
11516946
uniprot
proteins
sequence_length
302
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8TDX7}. Cytoplasm {ECO:0000250|UniProtKB:Q8TDX7}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q8TDX7}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q8TDX7}. Note=Present at centrosome throughout the cell cycle. Also detected at spindle midzone of the anaphase cells and eventually concentrates at the midbody (By similarity). Interaction with ANKS3 prevents its translocation to the nucleus (By similarity). {ECO:0000250|UniProtKB:Q8TDX7}.
uniprot
proteins