Tnk2
entrez
303882
canonical
uniprot
Q5U2X5
canonical
ensembl
ENSRNOG00000001769
resolver
ensp
ENSRNOP00000002411
resolver
ensp
ENSRNOP00000070836
resolver
ensp
ENSRNOP00000072336
resolver
enst
ENSRNOT00000002411
resolver
enst
ENSRNOT00000084768
resolver
enst
ENSRNOT00000085568
resolver
genesymbol
Tnk2
resolver
genesymbol_syn
Ack1
resolver
uniprot
A0A0G2JYY3
resolver
uniprot
A0A0G2K2Q7
resolver
uniprot
F1M7W9
resolver
uniprot_entry
A0A0G2JYY3_RAT
resolver
uniprot_entry
A0A0G2K2Q7_RAT
resolver
uniprot_entry
ACK1_RAT
resolver
uniprot_entry
F1M7W9_RAT
resolver
amino_acid_sequence
MQPEEGTGWLLELLSEVQLQQYFLRLRDDLNITRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKRRKAMCKRKSWMSKVFSGKRQEAEFPSHHSQSTFRKPSPTPGGLAGEGTLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPAGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDGHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRAENYWWRGQNTRTLCVGPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCWGFPDRIDELYLGNPMDPPDLLSVELSTSRPTQHLGRMKKPTYDPVSEDPDPLSSDFKRLGLRKPALPRGLWLAKPSARVPGTKAGRSSGGEVTLIDFGEEPVAPTPRPCAPSLAQLAMDACSLLDKTPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEVCSINSTLVSAGLPTGPSQGETNYAFVPEQAQLPPALEDNLFLPPQGGGQPPSSAQTAEIFQALQQECMRQLQVPTGQLTPSPTPGGDDKPQVPPRVPIPPRPTRPRVGLSPAPLGEEEASRWPGPSSPPRVPPREPLSPQGSRTPSPLVPPGSSPLPHRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRAGPCILPIVRDGRKVSSTHYYLLPERPPYLERYQRFLREAQSPEEPAALPVPPLLPPPSTPAPAAPTATVRPMPQAAPDPKANFSTNNSNPGAQPPSLRASARLPQRGCPGDGQEAARPADKVQMLQAMVHGVTTEECQAALRSHSWSIQRAAQYLKVEQLFGLGLRPRVECHKVLEMFDWNLEQAGCHLLGSCGPAHHKR
uniprot
proteins
ec_number
2.7.10.2
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363', thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
115068
uniprot
proteins
post_translational_modification
PTM: Autophosphorylation regulates kinase activity. Phosphorylation on Tyr-518 is required for interaction with SRC and is observed during association with clathrin-coated pits (By similarity). {ECO:0000250}.; PTM: Polyubiquitinated by NEDD4 and NEDD4L. Degradation can be induced by EGF and is lysosome-dependent (By similarity). {ECO:0000250}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Tyr protein kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
1040
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O54967}. Nucleus {ECO:0000250|UniProtKB:O54967}. Endosome {ECO:0000250|UniProtKB:O54967}. Cell junction, adherens junction {ECO:0000250|UniProtKB:O54967}. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side {ECO:0000250|UniProtKB:Q07912}. Cytoplasmic vesicle, clathrin-coated vesicle {ECO:0000250|UniProtKB:Q07912}. Membrane, clathrin-coated pit {ECO:0000250|UniProtKB:O54967}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:O54967}. Note=The Tyr-284 phosphorylated form is found both in the membrane and nucleus. Co-localizes with EGFR on endosomes. Nuclear translocation is CDC42-dependent. Detected in long filamentous cytosolic structures where it co-localizes with CTPS1. {ECO:0000250|UniProtKB:O54967}.
uniprot
proteins