Tab2
entrez
308267
canonical
uniprot
Q5U303
canonical
ensembl
ENSRNOG00000016054
resolver
ensembl
ENSRNOG00055009246
resolver
ensembl
ENSRNOG00060005760
resolver
ensembl
ENSRNOG00065024260
resolver
ensp
ENSRNOP00000021904
resolver
genesymbol
Tab2
resolver
genesymbol_syn
Map3k7ip2
resolver
uniprot_entry
TAB2_RAT
resolver
amino_acid_sequence
MAQGSHQIDFQVLHDLRQKFPEVPEVVVSRCMLQNNNNLDACCAVLSQESTRYLYGEGDLNFSDESGISGLRNHMTSLNLDLQSQNVYHHGREGSRVNGSRTLTHSVSDGQLQGGQSNNELFQQEPQTAPAQVPQGFNVFGMPSTSGASNSTPHLGFHLGSKGTSNLSQQTPRFNPIMVTLAPNIQTGRSTPTSLHIHGVPPPVLNSPQGNSIYIRPYITTPSGAARQTQQHSGWVSQFNPVNPQQAYQPSQPGPWTTYPASNPLPHTSTQQPNQQGHQTSHVYMPISSPTTPQPPTVHSSASSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNSSSKLRSSGPRTASTSSLVNSQTLNRNQPTVYIAASPPSTDEMISRSQPKVYISANASTGDEQGMRNQPTLFISTNSGASAASRNMSGQVSMGPAFIHHHPPKSRVLGGNSAASPRVVVTQPNTKYTFKITVSPNKPPAVSPGVVSPTFELTNLLNHPDHYVETETIQHLTDPTLAHVDRVSEARKLSMGSDDAAYTQALLVHQKARMERLQRELEMQKKKLDKLKSEVNEMENSLTRRRLKRSNSMSQIPSLEEMQQLRSCNRQLQIDIDCLTKEIDLFQARGPHFNPSAIHNFYDNIGFVGPVPPKPKDQRSTIKAPKTQDTEDEEGAQWNCTACTFLNHPALIRCEQCEMPRHF
uniprot
proteins
function
FUNCTION: Adapter required to activate the JNK and NF-kappa-B signaling pathways through the specific recognition of 'Lys-63'-linked polyubiquitin chains by its RanBP2-type zinc finger (NZF). Acts as an adapter linking MAP3K7/TAK1 and TRAF6 to 'Lys-63'-linked polyubiquitin chains. The RanBP2-type zinc finger (NZF) specifically recognizes Lys-63'-linked polyubiquitin chains unanchored or anchored to the substrate proteins such as RIPK1/RIP1 and RIPK2: this acts as a scaffold to organize a large signaling complex to promote autophosphorylation of MAP3K7/TAK1, and subsequent activation of I-kappa-B-kinase (IKK) core complex by MAP3K7/TAK1 (By similarity). Also recognizes and binds Lys-63'-linked polyubiquitin chains of heterotypic 'Lys-63'-/'Lys-48'-linked branched ubiquitin chains (By similarity). Regulates the IL1-mediated translocation of NCOR1 out of the nucleus (By similarity). Involved in heart development (By similarity). {ECO:0000250|UniProtKB:Q99K90, ECO:0000250|UniProtKB:Q9NYJ8}.
uniprot
proteins
mass_dalton
76328
uniprot
proteins
post_translational_modification
PTM: SUMOylated by TRIM60; leading to inhibition of MAPK/NF-kappaB activation and the innate immune response. {ECO:0000250|UniProtKB:Q9NYJ8}.; PTM: Ubiquitinated; following IL1 stimulation or TRAF6 overexpression. Ubiquitination involves RBCK1 leading to proteasomal degradation. Ubiquitinated at Lys-611 by TRIM45 leading to proteasomal degradation. {ECO:0000250|UniProtKB:Q9NYJ8}.; PTM: Degraded in a lysosome-dependent manner following interaction with TRIM38. {ECO:0000250|UniProtKB:Q9NYJ8}.; PTM: Phosphorylated. {ECO:0000250|UniProtKB:Q9NYJ8}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
693
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9NYJ8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9NYJ8}. Endosome membrane {ECO:0000250|UniProtKB:Q9NYJ8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9NYJ8}. Lysosome membrane {ECO:0000250|UniProtKB:Q9NYJ8}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9NYJ8}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q9NYJ8}. Note=Following IL1 stimulation, translocation occurs from the membrane to cytosol. Interaction with TRIM38 promotes translocation from cytosol to endosome and lysosome. {ECO:0000250|UniProtKB:Q9NYJ8}.
uniprot
proteins