MAP3K10
entrez
4294
canonical
uniprot
Q02779
canonical
ensembl
ENSG00000130758
resolver
ensp
ENSP00000253055
resolver
ensp
ENSP00000527002
resolver
enst
ENST00000253055
resolver
genesymbol
MAP3K10
resolver
genesymbol_syn
MLK2
resolver
genesymbol_syn
MST
resolver
hgnc
HGNC:6849
resolver
uniprot
Q12761
resolver
uniprot
Q14871
resolver
uniprot_entry
M3K10_HUMAN
resolver
uniprot_sec
Q12761
resolver
uniprot_sec
Q14871
resolver
activity_regulation
ACTIVITY REGULATION: Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MEEEEGAVAKEWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPGAPAAPAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPEKDPAVTAEQVCQEARLFGALQHPNIIALRGACLNPPHLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLLEECWDPDPHGRPDFGSILKRLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMCQLSQEKPRVRKRKGNFKRSRLLKLREGGSHISLPSGFEHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPVDCGGSSSGSSSGGSGTWSRGGPPKKEELVGGKKKGRTWGPSSTLQKERVGGEERLKGLGEGSKQWSSSAPNLGKSPKHTPIAPGFASLNEMEEFAEAEDGGSSVPPSPYSTPSYLSVPLPAEPSPGARAPWEPTPSAPPARWGHGARRRCDLALLGCATLLGAVGLGADVAEARAADGEEQRRWLDGLFFPRAGRFPRGLSPPARPHGRREDVGPGLGLAPSATLVSLSSVSDCNSTRSLLRSDSDEAAPAAPSPPPSPPAPTPTPSPSTNPLVDLELESFKKDPRQSLTPTHVTAACAVSRGHRRTPSDGALGQRGPPEPAGHGPGPRDLLDFPRLPDPQALFPARRRPPEFPGRPTTLTFAPRPRPAASRPRLDPWKLVSFGRTLTISPPSRPDTPESPGPPSVQPTLLDMDMEGQNQDSTVPLCGAHGSH
uniprot
proteins
ec_number
2.7.11.25
uniprot
proteins
function
FUNCTION: Activates the JUN N-terminal pathway. {ECO:0000250}.
uniprot
proteins
mass_dalton
103694
uniprot
proteins
post_translational_modification
PTM: Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation. {ECO:0000250}.
uniprot
proteins
protein_family
MAP kinase kinase kinase subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
7731697
uniprot
proteins
pubmed
8477742
uniprot
proteins
pubmed
8536694
uniprot
proteins
sequence_length
954
uniprot
proteins