PIK3R5
entrez
23533
canonical
uniprot
Q8WYR1
canonical
ensembl
ENSG00000141506
resolver
ensp
ENSP00000392812
resolver
ensp
ENSP00000462433
resolver
ensp
ENSP00000462680
resolver
ensp
ENSP00000477795
resolver
ensp
ENSP00000484211
resolver
ensp
ENSP00000485280
resolver
enst
ENST00000584803
resolver
genesymbol
PIK3R5
resolver
hgnc
HGNC:30035
resolver
uniprot
B0LPH4
resolver
uniprot
D3DTS3
resolver
uniprot
J3KSW1
resolver
uniprot
Q5G936
resolver
uniprot
Q5G938
resolver
uniprot
Q5G939
resolver
uniprot
Q8IZ23
resolver
uniprot
Q9Y2Y2
resolver
uniprot_entry
J3KSW1_HUMAN
resolver
uniprot_entry
PI3R5_HUMAN
resolver
uniprot_sec
B0LPH4
resolver
uniprot_sec
D3DTS3
resolver
uniprot_sec
Q5G936
resolver
uniprot_sec
Q5G938
resolver
uniprot_sec
Q5G939
resolver
uniprot_sec
Q8IZ23
resolver
uniprot_sec
Q9Y2Y2
resolver
activity_regulation
ACTIVITY REGULATION: Greatly activated by G gamma proteins. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MQPGATTCTEDRIQHALERCLHGLSLSRRSTSWSAGLCLNCWSLQELVSRDPGHFLILLEQILQKTREVQEKGTYDLLTPLALLFYSTVLCTPHFPPDSDLLLKAASTYHRFLTWPVPYCSICQELLTFIDAELKAPGISYQRLVRAEQGLPIRSHRSSTVTVLLLNPVEVQAEFLAVANKLSTPGHSPHSAYTTLLLHAFQATFGAHCDVPGLHCRLQAKTLAELEDIFTETAEAQELASGIGDAAEARRWLRTKLQAVGEKAGFPGVLDTAKPGKLHTIPIPVARCYTYSWSQDSFDILQEILLKEQELLQPGILGDDEEEEEEEEEVEEDLETDGHCAERDSLLSTSSLASHDSTLSLASSQASGPALSRHLLTSFVSGLSDGMDSGYVEDSEESSSEWPWRRGSQERRGHRRPGQKFIRIYKLFKSTSQLVLRRDSRSLEGSSDTALPLRRAGSLCSPLDEPVSPPSRAQRSRSLPQPKLGTQLPSWLLAPASRPQRRRPFLSGDEDPKASTLRVVVFGSDRISGKVARAYSNLRRLENNRPLLTRFFKLQFFYVPVKRSHGTSPGACPPPRSQTPSPPTDSPRHASPGELGTTPWEESTNDISHYLGMLDPWYERNVLGLMHLPPEVLCQQSLKAEAQALEGSPTQLPILADMLLYYCRFAARPVLLQVYQTELTFITGEKTTEIFIHSLELGHSAATRAIKASGPGSKRLGIDGDREAVPLTLQIIYSKGAISGRSRWSNLEKVCTSVNLNKACRKQEELDSSMEALTLNLTEVVKRQNSKSKKGFNQISTSQIKVDKVQIIGSNSCPFAVCLDQDERKILQSVVRCEVSPCYKPEKSDLSSPPQTPPDLPAQAAPDLCSLLCLPIMTFSGALP
uniprot
proteins
disease_involvement
DISEASE: Ataxia-oculomotor apraxia 3 (AOA3) [MIM:615217]: An autosomal recessive disease characterized by cerebellar ataxia, oculomotor apraxia, areflexia and peripheral neuropathy. {ECO:0000269|PubMed:22065524}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Regulatory subunit of the PI3K gamma complex. Required for recruitment of the catalytic subunit to the plasma membrane via interaction with beta-gamma G protein dimers. Required for G protein-mediated activation of PIK3CG (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
97348
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15797027
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
22065524
uniprot
proteins
sequence_length
880
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O02696}. Cytoplasm {ECO:0000250|UniProtKB:O02696}. Cell membrane {ECO:0000250|UniProtKB:O02696}; Peripheral membrane protein {ECO:0000250|UniProtKB:O02696}. Note=Predominantly localized in the nucleus in absence of PIK3CG/p120. Colocalizes with PIK3CG/p120 in the cytoplasm. Translocated to the plasma membrane in a beta-gamma G protein-dependent manner. {ECO:0000250|UniProtKB:O02696}.
uniprot
proteins