GFRA2
entrez
2675
canonical
uniprot
O00451
canonical
ensembl
ENSG00000168546
resolver
ensp
ENSP00000428518
resolver
ensp
ENSP00000429206
resolver
ensp
ENSP00000429979
resolver
ensp
ENSP00000548677
resolver
ensp
ENSP00000600283
resolver
genesymbol
GFRA2
resolver
genesymbol_syn
GDNFRB
resolver
genesymbol_syn
RETL2
resolver
genesymbol_syn
TRNR2
resolver
hgnc
HGNC:4244
resolver
uniprot
E9PD47
resolver
uniprot
O15316
resolver
uniprot
O15328
resolver
uniprot
Q58J92
resolver
uniprot
Q6GTR9
resolver
uniprot
Q7Z5C2
resolver
uniprot_entry
GFRA2_HUMAN
resolver
uniprot_sec
E9PD47
resolver
uniprot_sec
O15316
resolver
uniprot_sec
O15328
resolver
uniprot_sec
Q58J92
resolver
uniprot_sec
Q6GTR9
resolver
uniprot_sec
Q7Z5C2
resolver
amino_acid_sequence
MILANVFCLFFFLDETLRSLASPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEFYEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGMIGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKELSMCFTELTTNIIPGSNKVIKPNSGPSRARPSAALTVLSVLMLKLAL
uniprot
proteins
function
FUNCTION: Receptor for neurturin (NRTN), a growth factor that supports the survival of sympathetic neurons (PubMed:10829012, PubMed:29414779, PubMed:31535977, PubMed:9182803). NRTN-binding leads to autophosphorylation and activation of the RET receptor (PubMed:31535977). Also able to mediate GDNF signaling through the RET tyrosine kinase receptor (PubMed:9182803). {ECO:0000269|PubMed:10829012, ECO:0000269|PubMed:29414779, ECO:0000269|PubMed:31535977, ECO:0000269|PubMed:9182803}.; FUNCTION: [Isoform 2]: Participates in NRTN-induced 'Ser-727' phosphorylation of STAT3. {ECO:0000250|UniProtKB:O08842}.
uniprot
proteins
mass_dalton
51544
uniprot
proteins
protein_family
GDNFR family
uniprot
proteins
pubmed
10829012
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
23333276
uniprot
proteins
pubmed
29414779
uniprot
proteins
pubmed
31535977
uniprot
proteins
pubmed
9177201
uniprot
proteins
pubmed
9182803
uniprot
proteins
pubmed
9259272
uniprot
proteins
sequence_length
464
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:O08842}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:O08842}.
uniprot
proteins