ATXN2L
entrez
11273
canonical
uniprot
Q8WWM7
canonical
ensembl
ENSG00000168488
resolver
ensp
ENSP00000315650
resolver
ensp
ENSP00000338718
resolver
ensp
ENSP00000341459
resolver
ensp
ENSP00000372133
resolver
ensp
ENSP00000378917
resolver
ensp
ENSP00000454516
resolver
ensp
ENSP00000457613
resolver
ensp
ENSP00000562882
resolver
ensp
ENSP00000620694
resolver
ensp
ENSP00000720126
resolver
enst
ENST00000564304
resolver
genesymbol
ATXN2L
resolver
genesymbol_syn
A2D
resolver
genesymbol_syn
A2LG
resolver
genesymbol_syn
A2LP
resolver
genesymbol_syn
A2RP
resolver
hgnc
HGNC:31326
resolver
uniprot
A8K1R6
resolver
uniprot
B9EGM2
resolver
uniprot
E9PAR9
resolver
uniprot
H3BUF6
resolver
uniprot
O95135
resolver
uniprot
Q63ZY4
resolver
uniprot
Q6NVJ8
resolver
uniprot
Q6PJW6
resolver
uniprot
Q8IU61
resolver
uniprot
Q8IU95
resolver
uniprot
Q8WWM3
resolver
uniprot
Q8WWM4
resolver
uniprot
Q8WWM5
resolver
uniprot
Q8WWM6
resolver
uniprot
Q99703
resolver
uniprot_entry
ATX2L_HUMAN
resolver
uniprot_entry
H3BUF6_HUMAN
resolver
uniprot_sec
A8K1R6
resolver
uniprot_sec
B9EGM2
resolver
uniprot_sec
E9PAR9
resolver
uniprot_sec
O95135
resolver
uniprot_sec
Q63ZY4
resolver
uniprot_sec
Q6NVJ8
resolver
uniprot_sec
Q6PJW6
resolver
uniprot_sec
Q8IU61
resolver
uniprot_sec
Q8IU95
resolver
uniprot_sec
Q8WWM3
resolver
uniprot_sec
Q8WWM4
resolver
uniprot_sec
Q8WWM5
resolver
uniprot_sec
Q8WWM6
resolver
uniprot_sec
Q99703
resolver
amino_acid_sequence
MLKPQPLQQPSQPQQPPPTQQAVARRPPGGTSPPNGGLPGPLATSAAPPGPPAAASPCLGPVAAAGSGLRRGAEGILAPQPPPPQQHQERPGAAAIGSARGQSTGKGPPQSPVFEGVYNNSRMLHFLTAVVGSTCDVKVKNGTTYEGIFKTLSSKFELAVDAVHRKASEPAGGPRREDIVDTMVFKPSDVMLVHFRNVDFNYATKDKFTDSAIAMNSKVNGEHKEKVLQRWEGGDSNSDDYDLESDMSNGWDPNEMFKFNEENYGVKTTYDSSLSSYTVPLEKDNSEEFRQRELRAAQLAREIESSPQYRLRIAMENDDGRTEEEKHSAVQRQGSGRESPSLASREGKYIPLPQRVREGPRGGVRCSSSRGGRPGLSSLPPRGPHHLDNSSPGPGSEARGINGGPSRMSPKAQRPLRGAKTLSSPSNRPSGETSVPPPPAVGRMYPPRSPKSAAPAPISASCPEPPIGSAVPTSSASIPVTSSVSDPGVGSISPASPKISLAPTDVKELSTKEPGRTLEPQELARIAGKVPGLQNEQKRFQLEELRKFGAQFKLQPSSSPENSLDPFPPRILKEEPKGKEKEVDGLLTSEPMGSPVSSKTESVSDKEDKPPLAPSGGTEGPEQPPPPCPSQTGSPPVGLIKGEDKDEGPVAEQVKKSTLNPNAKEFNPTKPLLSVNKSTSTPTSPGPRTHSTPSIPVLTAGQSGLYSPQYISYIPQIHMGPAVQAPQMYPYPVSNSVPGQQGKYRGAKGSLPPQRSDQHQPASAPPMMQAAAAAGPPLVAATPYSSYIPYNPQQFPGQPAMMQPMAHYPSQPVFAPMLQSNPRMLTSGSHPQAIVSSSTPQYPSAEQPTPQALYATVHQSYPHHATQLHAHQPQPATTPTGSQPQSQHAAPSPVQHQAGQAPHLGSGQPQQNLYHPGALTGTPPSLPPGPSAQSPQSSFPQPAAVYAIHHQQLPHGFTNMAHVTQAHVQTGITAAPPPHPGAPHPPQVMLLHPPQSHGGPPQGAVPQSGVPALSASTPSPYPYIGHPQGEQPGQAPGFPGGADDRIREFSLAGGIWHGRAEGLQVGQDARVLGGE
uniprot
proteins
function
FUNCTION: Involved in the regulation of stress granule and P-body formation. {ECO:0000269|PubMed:23209657}.
uniprot
proteins
mass_dalton
113374
uniprot
proteins
mutagenesis
MUTAGEN 361; /note="R->Q: No effect on localization to stress granules under stress conditions."; /evidence="ECO:0000269|PubMed:25748791"; MUTAGEN 370; /note="R->Q: No effect on localization to stress granules under stress conditions."; /evidence="ECO:0000269|PubMed:25748791
uniprot
proteins
post_translational_modification
PTM: Thrombopoietin triggers the phosphorylation on tyrosine residues in a way that is dependent on MPL C-terminal domain. {ECO:0000269|PubMed:11784712}.; PTM: Asymmetrically dimethylated. Probably methylated by PRMT1. {ECO:0000269|PubMed:25748791}.
uniprot
proteins
protein_family
Ataxin-2 family
uniprot
proteins
pubmed
11784712
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14769358
uniprot
proteins
pubmed
15144186
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23209657
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25748791
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
8896555
uniprot
proteins
sequence_length
1075
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:11784712}; Peripheral membrane protein {ECO:0000269|PubMed:11784712}. Cytoplasm {ECO:0000269|PubMed:23209657}. Nucleus speckle {ECO:0000269|PubMed:23209657}. Cytoplasmic granule {ECO:0000269|PubMed:23209657}. Note=Predominantly cytoplasmic but is also detected in nuclear speckles (PubMed:23209657). Component of cytoplasmic stress granules (PubMed:23209657). Inhibition of methylation alters nuclear localization (PubMed:25748791). Methylation does not seem to be required for localization to stress granules under stress conditions (PubMed:25748791). {ECO:0000269|PubMed:23209657, ECO:0000269|PubMed:25748791}.
uniprot
proteins