ARHGEF25
entrez
115557
canonical
uniprot
Q86VW2
canonical
ensembl
ENSG00000240771
resolver
ensp
ENSP00000286494
resolver
ensp
ENSP00000335560
resolver
ensp
ENSP00000555419
resolver
genesymbol
ARHGEF25
resolver
genesymbol_syn
GEFT
resolver
hgnc
HGNC:30275
resolver
uniprot
A6NJH5
resolver
uniprot
A9CQZ6
resolver
uniprot
F8W7Z4
resolver
uniprot
Q8WV84
resolver
uniprot
Q96E63
resolver
uniprot_entry
ARHGP_HUMAN
resolver
uniprot_sec
A6NJH5
resolver
uniprot_sec
A9CQZ6
resolver
uniprot_sec
F8W7Z4
resolver
uniprot_sec
Q8WV84
resolver
uniprot_sec
Q96E63
resolver
amino_acid_sequence
MRGGHKGGRCACPRVIRKVLAKCGCCFARGGRESYSIAGSEGSISASAASGLAAPSGPSSGLSSGPCSPGPPGPVSGLRRWLDHSKHCLSVETEADSGQAGPYENWMLEPALATGEELPELTLLTTLLEGPGDKTQPPEEETLSQAPESEEEQKKKALERSMYVLSELVETEKMYVDDLGQIVEGYMATMAAQGVPESLRGRDRIVFGNIQQIYEWHRDYFLQELQRCLKDPDWLAQLFIKHERRLHMYVVYCQNKPKSEHVVSEFGDSYFEELRQQLGHRLQLNDLLIKPVQRIMKYQLLLKDFLKYYNRAGMDTADLEQAVEVMCFVPKRCNDMMTLGRLRGFEGKLTAQGKLLGQDTFWVTEPEAGGLLSSRGRERRVFLFEQIIIFSEALGGGVRGGTQPGYVYKNSIKVSCLGLEGNLQGDPCRFALTSRGPEGGIQRYVLQAADPAISQAWIKHVAQILESQRDFLNALQSPIEYQRRESQTNSLGRPRGPGVGSPGRIQLGDQAQGSTHTPINGSLPSLLLSPKGEVARALLPLDKQALGDIPQAPHDSPPVSPTPKTPPCQARLAKLDEDEL
uniprot
proteins
function
FUNCTION: May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity). {ECO:0000250, ECO:0000269|PubMed:11861769, ECO:0000269|PubMed:12547822, ECO:0000269|PubMed:15069594, ECO:0000269|PubMed:15632174, ECO:0000269|PubMed:16314529, ECO:0000269|PubMed:17606614}.
uniprot
proteins
mass_dalton
63843
uniprot
proteins
mutagenesis
MUTAGEN 301; /note="L->E: Abolishes its exchange activity on RHOA."; /evidence="ECO:0000269|PubMed:11861769"; MUTAGEN 471; /note="F->A: Reduces exchange activity mediated by GNAQ activation; in truncated construct."; /evidence="ECO:0000269|PubMed:17606614"; MUTAGEN 472; /note="L->A: Reduces exchange activity mediated by GNAQ activation; in truncated construct."; /evidence="ECO:0000269|PubMed:17606614"; MUTAGEN 475; /note="L->A: Reduces exchange activity mediated by GNAQ activation; in truncated construct."; /evidence="ECO:0000269|PubMed:17606614"; MUTAGEN 478; /note="P->A: Reduces exchange activity mediated by GNAQ activation; in truncated construct."; /evidence="ECO:0000269|PubMed:17606614"; MUTAGEN 479; /note="I->A: Reduces exchange activity mediated by GNAQ activation; in truncated construct."; /evidence="ECO:0000269|PubMed:17606614
uniprot
proteins
pubmed
11861769
uniprot
proteins
pubmed
12547822
uniprot
proteins
pubmed
15069594
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15632174
uniprot
proteins
pubmed
16314529
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17606614
uniprot
proteins
pubmed
18096806
uniprot
proteins
sequence_length
580
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}. Cytoplasm, myofibril, sarcomere {ECO:0000269|PubMed:11861769}. Note=Highly colocalizes with actin regions.
uniprot
proteins