SMAD5
entrez
4090
canonical
uniprot
Q99717
canonical
ensembl
ENSG00000113658
resolver
ensp
ENSP00000426696
resolver
ensp
ENSP00000441954
resolver
ensp
ENSP00000446474
resolver
ensp
ENSP00000535452
resolver
ensp
ENSP00000535453
resolver
ensp
ENSP00000535455
resolver
ensp
ENSP00000535456
resolver
ensp
ENSP00000535457
resolver
ensp
ENSP00000595722
resolver
ensp
ENSP00000595723
resolver
ensp
ENSP00000595724
resolver
ensp
ENSP00000595725
resolver
ensp
ENSP00000595726
resolver
ensp
ENSP00000623302
resolver
enst
ENST00000509297
resolver
enst
ENST00000545279
resolver
enst
ENST00000545620
resolver
enst
ENST00000865393
resolver
enst
ENST00000865394
resolver
enst
ENST00000865396
resolver
enst
ENST00000865397
resolver
enst
ENST00000865398
resolver
enst
ENST00000925663
resolver
enst
ENST00000925664
resolver
enst
ENST00000925665
resolver
enst
ENST00000925666
resolver
enst
ENST00000925667
resolver
enst
ENST00000953243
resolver
genesymbol
DKFZp781O1323
resolver
genesymbol
SMAD5
resolver
genesymbol_syn
DKFZp781C1895
resolver
genesymbol_syn
MADH5
resolver
genesymbol_syn
SMAD5
resolver
hgnc
HGNC:6771
resolver
uniprot
O14688
resolver
uniprot
Q15798
resolver
uniprot
Q68DB7
resolver
uniprot
Q9UQA1
resolver
uniprot_entry
Q68DB7_HUMAN
resolver
uniprot_entry
SMAD5_HUMAN
resolver
uniprot_sec
O14688
resolver
uniprot_sec
Q15798
resolver
uniprot_sec
Q9UQA1
resolver
amino_acid_sequence
MTSMASLFSFTSPAVKRLLGWKQGDEEEKWAEKAVDALVKKLKKKKGAMEELEKALSSPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVCINPYHYKRVESPVLPPVLVPRHNEFNPQHSLLVQFRNLSHNEPHMPQNATFPDSFHQPNNTPFPLSPNSPYPPSPASSTYPNSPASSGPGSPFQLPADTPPPAYMPPDDQMGQDNSQPMDTSNNMIPQIMPSISSRDVQPVAYEEPKHWCSIVYYELNNRVGEAFHASSTSVLVDGFTDPSNNKSRFCLGLLSNVNRNSTIENTRRHIGKGVHLYYVGGEVYAECLSDSSIFVQSRNCNFHHGFHPTTVCKIPSSCSLKIFNNQEFAQLLAQSVNHGFEAVYELTKMCTIRMSFVKGWGAEYHRQDVTSTPCWIEIHLHGPLQWLDKVLTQMGSPLNPISSVS
uniprot
proteins
function
FUNCTION: Transcriptional regulator that plays a role in various cellular processes including embryonic development, cell differentiation, angiogenesis and tissue homeostasis (PubMed:12064918, PubMed:16516194). Upon BMP ligand binding to their receptors at the cell surface, is phosphorylated by activated type I BMP receptors (BMPRIs) and associates with SMAD4 to form a heteromeric complex which translocates into the nucleus acting as transcription factor (PubMed:9442019). In turn, the hetero-trimeric complex recognizes cis-regulatory elements containing Smad Binding Elements (SBEs) to modulate the outcome of the signaling network (PubMed:33510867). Non-phosphorylated SMAD5 has a cytoplasmic role in energy metabolism regulation by promoting mitochondrial respiration and glycolysis in response to cytoplasmic pH changes (PubMed:28675158). Mechanistically, interacts with hexokinase 1/HK1 and thereby accelerates glycolysis (PubMed:28675158). {ECO:0000269|PubMed:12064918, ECO:0000269|PubMed:16516194, ECO:0000269|PubMed:28675158, ECO:0000269|PubMed:33510867, ECO:0000269|PubMed:9442019}.
uniprot
proteins
mass_dalton
52258
uniprot
proteins
mutagenesis
MUTAGEN 419; /note="G->S: Loss of phosphorylation and interaction with SMAD4."; /evidence="ECO:0000269|PubMed:9442019
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine by BMP (bone morphogenetic proteins) type 1 receptor kinase. {ECO:0000269|PubMed:12064918}.; PTM: Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.
uniprot
proteins
protein_family
Dwarfin/SMAD family
uniprot
proteins
pubmed
10647776
uniprot
proteins
pubmed
10708948
uniprot
proteins
pubmed
10708949
uniprot
proteins
pubmed
12064918
uniprot
proteins
pubmed
12370310
uniprot
proteins
pubmed
12849988
uniprot
proteins
pubmed
15107829
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15647271
uniprot
proteins
pubmed
16516194
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
25755279
uniprot
proteins
pubmed
28675158
uniprot
proteins
pubmed
33510867
uniprot
proteins
pubmed
8673135
uniprot
proteins
pubmed
9264367
uniprot
proteins
pubmed
9288787
uniprot
proteins
pubmed
9442019
uniprot
proteins
pubmed
9484787
uniprot
proteins
pubmed
9759503
uniprot
proteins
sequence_length
465
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16516194, ECO:0000269|PubMed:28675158, ECO:0000269|PubMed:9442019}. Nucleus {ECO:0000269|PubMed:28675158, ECO:0000269|PubMed:9442019}. Mitochondrion {ECO:0000269|PubMed:12849988}. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4. {ECO:0000269|PubMed:9442019}.
uniprot
proteins