Spata13
entrez
219140
canonical
uniprot
Q5DU57
canonical
ensembl
ENSMUSG00000021990
resolver
ensp
ENSMUSP00000022566
resolver
ensp
ENSMUSP00000123888
resolver
ensp
ENSMUSP00000123928
resolver
enst
ENSMUST00000022566
resolver
enst
ENSMUST00000160973
resolver
enst
ENSMUST00000162945
resolver
genesymbol
Spata13
resolver
uniprot
E0CYU0
resolver
uniprot
E9Q3I3
resolver
uniprot
Q3TZ09
resolver
uniprot_entry
E0CYU0_MOUSE
resolver
uniprot_entry
E9Q3I3_MOUSE
resolver
uniprot_entry
SPT13_MOUSE
resolver
uniprot_sec
Q3TZ09
resolver
activity_regulation
ACTIVITY REGULATION: Both the ABR and the SH3 domains contribute to maintaining the protein in an inhibited conformation by associating with the C-terminal tail. Binding of these domains to the C-terminal tail inhibits the activity of the protein by blocking a region that is required for its GEF activity (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MHPASVTTTSQDPCAPSGSCRGGRRRRPISVIGGVSFYGNTQVEDVENLLVQPAARPPVPAHQVPPYKAVSARLRPFTFSQSTPIGLDRVGRRRQMKTSNVSSDGGAESSALVDDNGSEEDFSYEELCQANPRYLQPGGEQLAINELISDGSVVCAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRNEDKEAWFPASFVRLRVNQEELPENCSSSHGEEQDEDTSKARHKHPESQQQMRTNVIQEIMNTERVYIKHLKDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFLKDLEKQYNKEEPHLSEIGSCFLEHQEGFAIYSEYCNNHPGACVELSNLMKHSKYRHFFEACRLLQQMIDIALDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYNNIKAAYEAMKNVACLINERKRKLESIDKIARWQVSIVGWEGLDILDRSSELIHSGELTKITRQGKSQQRIFFLFDHQLVSCKKDLLRRDMLYYKGRMDMDEVELVDVEDGRDKDWSLSLRNAFKLVSKATDEVHLFCARKQEDKARWLQAYADERRRVQEDQQMGMEIPENQKKLAMLNAQKAGHGKSKGYNSCPVAPPHQSLPPLHQRHITVPTSIPQQQVFALAEPKRKPSIFWHTFHKLTPFRK
uniprot
proteins
function
FUNCTION: Acts as a guanine nucleotide exchange factor (GEF) for RHOA, RAC1 and CDC42 GTPases. Regulates cell migration and adhesion assembly and disassembly through a RAC1, PI3K, RHOA and AKT1-dependent mechanism. Increases both RAC1 and CDC42 activity, but decreases the amount of active RHOA (By similarity). Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Involved in tumor angiogenesis and may play a role in intestinal adenoma formation and tumor progression. {ECO:0000250, ECO:0000269|PubMed:19893577}.
uniprot
proteins
mass_dalton
75257
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19893577
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23525008
uniprot
proteins
sequence_length
656
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell projection, filopodium {ECO:0000250}. Cell projection, lamellipodium {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000250}. Cell projection, podosome {ECO:0000269|PubMed:23525008}. Note=Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment. Localized to the core of myotube podosomes (PubMed:23525008). {ECO:0000250, ECO:0000269|PubMed:23525008}.
uniprot
proteins