Mark1
entrez
117016
canonical
uniprot
O08678
canonical
ensembl
ENSRNOG00000002339
resolver
ensp
ENSRNOP00000003198
resolver
ensp
ENSRNOP00000074213
resolver
enst
ENSRNOT00000003198
resolver
genesymbol
Mark1
resolver
uniprot
A0A8L2Q1K3
resolver
uniprot_entry
A0A8L2Q1K3_RAT
resolver
uniprot_entry
MARK1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by phosphorylation on Thr-215. Inhibited by phosphorylation at Ser-219. {ECO:0000269|PubMed:14517247}.
uniprot
proteins
amino_acid_sequence
MSARTPLPTVNERDTENHTSVDGYTETHIPPTKSSSRQNIPRCRNSITSATDEQPHIGNYRLQKTIGKGNFAKVKLARHVLTGREVAVKIIDKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAHGRMKEKEARAKFRQIVSAVQYCHQKCIVHRDLKAENLLLDADMNIKIADFGFSNEFTVGNKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKELRERVLRGKYRVPFYMSTDCENLLKKLLVLNPIKRGSLEQIMKDRWMNVGHEEEELKPYSEPELDLNDAKRIDIMVTMGFARDEINDALVSQKYDEVMATYILLGRKPPEFEGGESLSSGNLCQRSRPSSDLNNSTLQSPAHLKVQRSISANQKQRRFSDHAGPSIPPAVSYTKRPQANSVESEQKEEWDKDTARRLGSTTVGSKSEVTASPLVGPDRKKSSAGPSNNVYSGGSMTRRNTYVCERSTDRYAALQNGRDSSLTEMSASSMSSTGSTVASAGPSARPRHQKSMSTSGHPIKVTLPTIKDGSEAYRPGTAQRVPAASPSAHSISASTPDRTRFPRGSSSRSTFHGEQLRERRSAAYSGPPASPSHDTAALAHARRGTSTGIISKITSKFVRRDPSEGEASGRTDTARGSSGEPKDKEEGKEAKPRSLRFTWSMKTTSSMDPNDMVREIRKVLDANTCDYEQRERFLLFCVHGDARQDSLVQWEMEVCKLPRLSLNGVRFKRISGTSIAFKNIASKIANELKL
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
ec_number
2.7.11.26
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase (By similarity). Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU (By similarity). Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3) (PubMed:14517247, PubMed:14741102, PubMed:9108484). {ECO:0000250|UniProtKB:Q9P0L2, ECO:0000269|PubMed:14517247, ECO:0000269|PubMed:14741102, ECO:0000269|PubMed:9108484}.
uniprot
proteins
mass_dalton
88235
uniprot
proteins
mutagenesis
MUTAGEN 89; /note="K->R: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:9108484"; MUTAGEN 215; /note="T->A: Abolishes activation of serine/threonine-protein kinase activity and only basal activity remains."; /evidence="ECO:0000269|PubMed:14517247, ECO:0000269|PubMed:9108484"; MUTAGEN 215; /note="T->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:14517247, ECO:0000269|PubMed:9108484"; MUTAGEN 215; /note="T->E: Induces an increase of the basal serine/threonine-protein kinase activity."; /evidence="ECO:0000269|PubMed:14517247, ECO:0000269|PubMed:9108484"; MUTAGEN 219; /note="S->A,E: Loss of activity."; /evidence="ECO:0000269|PubMed:14517247, ECO:0000269|PubMed:9108484"; MUTAGEN 219; /note="S->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:14517247, ECO:0000269|PubMed:9108484
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Thr-613 by PRKCZ/aPKC in polarized epithelial cells inhibits the kinase activity (By similarity). Phosphorylated at Thr-215 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Phosphorylation at Thr-215 by TAOK1 activates the kinase activity, leading to phosphorylation and detachment of MAPT/TAU from microtubules. Phosphorylation at Ser-219 by GSK3-beta (GSK3B) inhibits the kinase activity. {ECO:0000250, ECO:0000269|PubMed:14517247, ECO:0000269|PubMed:9108484}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
SNF1 subfamily
uniprot
proteins
pubmed
14517247
uniprot
proteins
pubmed
14741102
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9108484
uniprot
proteins
sequence_length
793
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:9108484}. Cytoplasm {ECO:0000250|UniProtKB:Q9P0L2}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q9P0L2}. Note=Appears to localize to an intracellular network.
uniprot
proteins