CALHM3
entrez
119395
canonical
uniprot
Q86XJ0
canonical
ensembl
ENSG00000183128
resolver
ensp
ENSP00000358798
resolver
enst
ENST00000369783
resolver
genesymbol
CALHM3
resolver
genesymbol_syn
FAM26A
resolver
hgnc
HGNC:23458
resolver
uniprot
Q5W090
resolver
uniprot
Q8IXR2
resolver
uniprot_entry
CAHM3_HUMAN
resolver
uniprot_sec
Q5W090
resolver
uniprot_sec
Q8IXR2
resolver
amino_acid_sequence
MDKFRMLFQHFQSSSESVMNGICLLLAAVTVKLYSSFDFNCPCLVHYNALYGLGLLLTPPLALFLCGLLANRQSVVMVEEWRRPAGHRRKDPGIIRYMCSSVLQRALAAPLVWILLALLDGKCFVCAFSSSVDPEKFLDFANMTPSQVQLFLAKVPCKEDELVRDSPARKAVSRYLRCLSQAIGWSVTLLLIIAAFLARCLRPCFDQTVFLQRRYWSNYVDLEQKLFDETCCEHARDFAHRCVLHFFASMRSELQARGLRRGNAGRRLELPAVPEPPEGLDSGSGKAHLRAISSREQVDRLLSTWYSSKPPLDLAASPGLCGGGLSHRAPTLALGTRLSQHTDV
uniprot
proteins
function
FUNCTION: Pore-forming subunit of gustatory voltage-gated ion channels required for sensory perception of sweet, bitter and umami tastes. With CALHM1 forms a fast-activating voltage-gated ATP-release channel in type II taste bud cells, ATP acting as a neurotransmitter to activate afferent neural gustatory pathways. Acts both as a voltage-gated and calcium-activated ion channel: mediates neuronal excitability in response to membrane depolarization and low extracellular Ca(2+) concentration. Has poor ion selectivity and forms a wide pore (around 14 Angstroms) that mediates permeation of small ions including Ca(2+), Na(+), K(+) and Cl(-), as well as larger ions such as ATP(4-). {ECO:0000250|UniProtKB:J3QMI4}.
uniprot
proteins
mass_dalton
38496
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000250|UniProtKB:J3QMI4}.; PTM: Palmitoylated by ZDHHC3 and ZDHHC15. Palmitoylation positively regulates CALHM1:CALHM3 channel conductance. {ECO:0000250|UniProtKB:J3QMI4}.
uniprot
proteins
protein_family
CALHM family
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18585350
uniprot
proteins
pubmed
19997627
uniprot
proteins
sequence_length
344
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Basolateral cell membrane {ECO:0000250|UniProtKB:J3QMI4}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..36; /note="Helical; Name=S1"; /evidence="ECO:0000250|UniProtKB:H2MCM1, ECO:0000250|UniProtKB:Q8IU99"; TRANSMEM 49..71; /note="Helical; Name=S2"; /evidence="ECO:0000250|UniProtKB:H2MCM1, ECO:0000250|UniProtKB:Q8IU99"; TRANSMEM 99..124; /note="Helical; Name=S3"; /evidence="ECO:0000250|UniProtKB:H2MCM1, ECO:0000250|UniProtKB:Q8IU99"; TRANSMEM 177..202; /note="Helical; Name=S4"; /evidence="ECO:0000250|UniProtKB:H2MCM1, ECO:0000250|UniProtKB:Q8IU99
uniprot
proteins