Akr1c8
entrez
361267
canonical
uniprot
D3ZF77
canonical
ensembl
ENSRNOG00000021735
resolver
ensp
ENSRNOP00000055113
resolver
enst
ENSRNOT00000058312
resolver
genesymbol
Akr1c15
resolver
genesymbol
Akr1c8
resolver
genesymbol_syn
17beta-HSD
resolver
genesymbol_syn
Akr1c15
resolver
genesymbol_syn
Akr1cl
resolver
uniprot
A0A387KC71
resolver
uniprot_entry
A0A387KC71_RAT
resolver
uniprot_entry
AK1CA_RAT
resolver
activity_regulation
ACTIVITY REGULATION: The dehydrogenase activity is inhibited by 3',3'',5',5''-tetraiodophenolphthalein, phenolphthalein, genistein, quercetin, zearalenone and diethylstilbestrol. {ECO:0000269|PubMed:17574202}.
uniprot
proteins
amino_acid_sequence
MDLKHSRSVKLNDGNLMPVLGFGTFASKEIPKSKAAEATKVAIDVGFRHIDAAYFYQNEEEVGQALRDKMADGTVKREDLFYTTKIWITFLRPELVRQCLERSLKKLGLDYVDLCIIHIPIAMKPGEELLPKDANGKFIFDTVDIRDTWEALEKCKDAGLSKSIGVSNFNHKQLELILNKPRLKYKPTCNQVECHPYLNQSKLLEFCKSKDIVLVAYSALGSHRDSSWVSSDSPYLLEDPVLMTIAKKHNQTPGQVALRYQLQRGVVVLAKSFNEKRIKENFQVFDFELTPEDMKTIDSLNRNFRYSQMAFALDHPDYPFLEEY
uniprot
proteins
ec_number
1.1.1.-
uniprot
proteins
ec_number
1.1.1.216
uniprot
proteins
function
FUNCTION: Catalyzes the NADPH-dependent reduction of a variety of substrates including aromatic and aliphatic aldehydes, quinones, ketones, dicarbonyl compounds and 17-ketosteroids (PubMed:17574202). Catalyzes the NADP(+)-dependent oxidation of aromatic, alicyclic and aliphatic alcohols, and 17beta-hydroxysteroids (PubMed:17574202). To a lesser extent, can also catalyze the reduction of some aldoses and ketoses and the oxidation of some sugar alcohols (PubMed:17574202). In the stomach, lung and colon tissues, mediates the reduction of farnesal and geranylgeranial into farnesol and geranylgeraniol respectively (PubMed:21187079). By reducing 4-hydroxy-2-nonenal (HNE), produced during lipid peroxidation, into 1,4-dihydro-2-nonene (DHN), protects vascular endothelial cells from damage elicited by oxidized lipoproteins (PubMed:21187080). {ECO:0000269|PubMed:17574202, ECO:0000269|PubMed:21187079, ECO:0000269|PubMed:21187080}.
uniprot
proteins
mass_dalton
37195
uniprot
proteins
protein_family
Aldo/keto reductase family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
17574202
uniprot
proteins
pubmed
21187079
uniprot
proteins
pubmed
21187080
uniprot
proteins
pubmed
7511002
uniprot
proteins
sequence_length
324
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17574202, ECO:0000269|PubMed:21187079}.
uniprot
proteins