RDH16
entrez
8608
canonical
uniprot
O75452
canonical
ensembl
ENSG00000139547
resolver
ensp
ENSP00000381206
resolver
ensp
ENSP00000539380
resolver
ensp
ENSP00000539381
resolver
enst
ENST00000398138
resolver
enst
ENST00000869321
resolver
enst
ENST00000869322
resolver
genesymbol
RDH16
resolver
genesymbol_syn
RODH4
resolver
genesymbol_syn
SDR9C8
resolver
hgnc
HGNC:29674
resolver
uniprot
Q59FX7
resolver
uniprot
Q9UNV2
resolver
uniprot_entry
Q59FX7_HUMAN
resolver
uniprot_entry
RDH16_HUMAN
resolver
uniprot_sec
Q9UNV2
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by citral, perillyl alcohol, geraniol, farnesol and geranyl geraniol. {ECO:0000269|PubMed:9677409}.
uniprot
proteins
amino_acid_sequence
MWLYLAVFVGLYYLLHWYRERQVLSHLRDKYVFITGCDSGFGKLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTKTESVAAAAQWVKECVRDKGLWGLVNNAGISLPTAPNELLTKQDFVTILDVNLLGVIDVTLSLLPLVRRARGRVVNVSSVMGRVSLFGGGYCISKYGVEAFSDSLRRELSYFGVKVAMIEPGYFKTAVTSKERFLKSFLEIWDRSSPEVKEAYGEKFVADYKKSAEQMEQKCTQDLSLVTNCMEHALIACHPRTRYSAGWDAKLLYLPMSYMPTFLVDAIMYWVSPSPAKAL
uniprot
proteins
ec_number
1.1.1.105
uniprot
proteins
ec_number
1.1.1.209
uniprot
proteins
ec_number
1.1.1.315
uniprot
proteins
ec_number
1.1.1.53
uniprot
proteins
function
FUNCTION: Oxidoreductase with a preference for NAD. Oxidizes all-trans-retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes (PubMed:10329026, PubMed:12534290, PubMed:9677409). Has higher activity towards CRBP-bound retinol than with free retinol (PubMed:12534290). Also oxidizes 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction (PubMed:10329026, PubMed:29541409, PubMed:9677409). {ECO:0000269|PubMed:10329026, ECO:0000269|PubMed:12534290, ECO:0000269|PubMed:29541409, ECO:0000269|PubMed:9677409}.
uniprot
proteins
mass_dalton
35673
uniprot
proteins
mutagenesis
MUTAGEN 176; /note="Y->F: Decreases androsterone dehydrogenase activity; when associated with R-180."; /evidence="ECO:0000269|PubMed:29541409"; MUTAGEN 180; /note="K->R: Decreases androsterone dehydrogenase activity; when associated with F-176."; /evidence="ECO:0000269|PubMed:29541409
uniprot
proteins
pathway_participation
PATHWAY: Cofactor metabolism; retinol metabolism. {ECO:0000269|PubMed:10329026, ECO:0000269|PubMed:9677409}.
uniprot
proteins
post_translational_modification
PTM: Not N-glycosylated. {ECO:0000269|PubMed:12534290}.
uniprot
proteins
protein_family
Short-chain dehydrogenases/reductases (SDR) family
uniprot
proteins
pubmed
10329026
uniprot
proteins
pubmed
11967490
uniprot
proteins
pubmed
12534290
uniprot
proteins
pubmed
19027726
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
29541409
uniprot
proteins
pubmed
9677409
uniprot
proteins
sequence_length
317
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Microsome membrane {ECO:0000269|PubMed:9677409}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O54909}; Single-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 289..309; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins