ASIC5
entrez
51802
canonical
uniprot
Q9NY37
canonical
ensembl
ENSG00000256394
resolver
ensp
ENSP00000442477
resolver
enst
ENST00000537611
resolver
genesymbol
ASIC5
resolver
genesymbol_syn
ACCN5
resolver
hgnc
HGNC:17537
resolver
uniprot_entry
ASIC5_HUMAN
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by the diuretic drug amiloride. {ECO:0000305|PubMed:10767424}.
uniprot
proteins
amino_acid_sequence
MEQTEKSKVYAENGLLEKIKLCLSKKPLPSPTERKKFDHDFAISTSFHGIHNIVQNRSKIRRVLWLVVVLGSVSLVTWQIYIRLLNYFTWPTTTSIEVQYVEKMEFPAVTFCNLNRFQTDAVAKFGVIFFLWHIVSKVLHLQEITANSTGSREATDFAASHQNFSIVEFIRNKGFYLNNSTLLDCEFFGKPCSPKDFAHVFTEYGNCFTFNHGETLQAKRKVSVSGRGLSLLFNVNQEAFTDNPALGFVDAGIIFVIHSPKKVPQFDGLGLLSPVGMHARVTIRQVKTVHQEYPWGECNPNIKLQNFSSYSTSGCLKECKAQHIKKQCGCVPFLLPGYGIECDLQKYFSCVSPVLDHIEFKDLCTVGTHNSSCPVSCEEIEYPATISYSSFPSQKALKYLSKKLNQSRKYIRENLVKIEINYSDLNYKITQQQKAVSVSELLADLGGQLGLFCGASLITIIEIIEYLFTNFYWICIFFLLKISEMTQWTPPPQNHLGNKNRIEEC
uniprot
proteins
function
FUNCTION: Forms bile acid-gated sodium channels and may play a role in bile acid-dependent absorption and secretion by epithelial cells of the bile ducts (PubMed:10767424, PubMed:22735174). Displays high selectivity for sodium ions but can also permit the permeation of other cations (Probable). The gating could be indirect and the consequence of alterations of the membrane environment of the channel by bile acids (By similarity). As a sodium channel of type II unipolar brush cells of the vestibulocerebellum, controlling the electrical activity of these cells, could play a role in motor coordination and balance (By similarity). {ECO:0000250|UniProtKB:Q9R0W5, ECO:0000250|UniProtKB:Q9R0Y1, ECO:0000269|PubMed:10767424, ECO:0000269|PubMed:22735174, ECO:0000305|PubMed:22735174}.
uniprot
proteins
mass_dalton
57464
uniprot
proteins
mutagenesis
MUTAGEN 443; /note="A->C: Slightly activates the channel."; /evidence="ECO:0000269|PubMed:10767424"; MUTAGEN 443; /note="A->F,T: Activates the channel."; /evidence="ECO:0000269|PubMed:10767424
uniprot
proteins
protein_family
ASIC5 subfamily
uniprot
proteins
protein_family
Amiloride-sensitive sodium channel (TC 1.A.6) family
uniprot
proteins
pubmed
10767424
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
22735174
uniprot
proteins
sequence_length
505
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q9R0W5}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:10767424}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 62..82; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 460..480; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins