FBXO45
entrez
200933
canonical
uniprot
P0C2W1
canonical
ensembl
ENSG00000174013
resolver
ensp
ENSP00000310332
resolver
enst
ENST00000311630
resolver
genesymbol
FBXO45
resolver
genesymbol_syn
FBX45
resolver
hgnc
HGNC:29148
resolver
uniprot
A6NF90
resolver
uniprot
D3DXB5
resolver
uniprot_entry
FBSP1_HUMAN
resolver
uniprot_sec
A6NF90
resolver
uniprot_sec
D3DXB5
resolver
amino_acid_sequence
MAAPAPGAGAASGGAGCSGGGAGAGAGSGSGAAGAGGRLPSRVLELVFSYLELSELRSCALVCKHWYRCLHGDENSEVWRSLCARSLAEEALRTDILCNLPSYKAKIRAFQHAFSTNDCSRNVYIKKNGFTLHRNPIAQSTDGARTKIGFSEGRHAWEVWWEGPLGTVAVIGIATKRAPMQCQGYVALLGSDDQSWGWNLVDNNLLHNGEVNGSFPQCNNAPKYQIGERIRVILDMEDKTLAFERGYEFLGVAFRGLPKVCLYPAVSAVYGNTEVTLVYLGKPLDG
uniprot
proteins
function
FUNCTION: Component of E3 ubiquitin ligase complex consisting of FBXO45, MYCBP2 and SKP1 (PubMed:29997255). Functions in substrate recognition but also plays an important role in assembly of the complex (PubMed:29997255). Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Regulates neuron migration during brain development through interaction with N-cadherin/CDH2 after secretion via a non-classical mechanism (By similarity). Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May control synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation. Polyubiquitinates NMNAT2, an adenylyltransferase that acts as an axon maintenance factor, and regulates its stability and degradation by the proteasome (PubMed:29997255). Also acts by ubiquitinating FBXW7 during prolonged mitotic arrest and promotes FBXW7 proteasomal degradation (PubMed:31285543). Induces subsequently an increase in mitotic slippage and prevents mitotic cell death (PubMed:31285543). In response to influenza infection, mediates interferon-lambda receptor IFNLR1 polyubiquitination and degradation through the ubiquitin-proteasome system by docking with its intracellular receptor domain (PubMed:36379255). {ECO:0000250|UniProtKB:P0CH38, ECO:0000250|UniProtKB:Q8K3B1, ECO:0000269|PubMed:19581926, ECO:0000269|PubMed:29997255, ECO:0000269|PubMed:31285543, ECO:0000269|PubMed:36379255}.
uniprot
proteins
mass_dalton
30633
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
protein_family
FBXO45/Fsn family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15520277
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19581926
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
26068074
uniprot
proteins
pubmed
29997255
uniprot
proteins
pubmed
31285543
uniprot
proteins
pubmed
32341084
uniprot
proteins
pubmed
36379255
uniprot
proteins
sequence_length
286
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:32341084}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P0CH38}. Presynaptic cell membrane {ECO:0000250|UniProtKB:P0CH38}. Nucleus {ECO:0000269|PubMed:26068074}. Note=Secreted by a non-classical mechanism. {ECO:0000269|PubMed:32341084}.
uniprot
proteins