PRDM7
entrez
11105
canonical
uniprot
Q9NQW5
canonical
ensembl
ENSG00000126856
resolver
ensp
ENSP00000396732
resolver
ensp
ENSP00000455390
resolver
genesymbol
PRDM7
resolver
genesymbol_syn
PFM4
resolver
hgnc
HGNC:9351
resolver
uniprot
A4Q9G8
resolver
uniprot
Q08EM4
resolver
uniprot
Q9NQW4
resolver
uniprot_entry
PRDM7_HUMAN
resolver
uniprot_sec
A4Q9G8
resolver
uniprot_sec
Q08EM4
resolver
uniprot_sec
Q9NQW4
resolver
amino_acid_sequence
MSPERSQEESPEGDTERTERKPMVKDAFKDISIYFTKEEWAEMGDWEKTRYRNVKMNYNALITVGLRATRPAFMCHRRQAIKLQVDDTEDSDEEWTPRQQVKPPWMAFRGEQSKHQKGMPKASFNNESSLRELSGTPNLLNTSDSEQAQKPVSPPGEASTSGQHSRLKLELRRKETEGKMYSLRERKGHAYKEISEPQDDDYLYCEMCQNFFIDSCAAHGPPTFVKDSAVDKGHPNRSALSLPPGLRIGPSGIPQAGLGVWNEASDLPLGLHFGPYEGRITEDEEAANSGYSWLITKGRNCYEYVDGKDKSSANWMRYVNCARDDEEQNLVAFQYHRQIFYRTCRVIRPGCELLVWSGDEYGQELGIRSSIEPAESLGQAVNCWSGMGMSMARNWASSGAASGRKSSWQGENQSQRSIHVPHAVWPFQVKNFSVNMWNAITPLRTSQDHLQENFSNQRIPAQGIRIRSGNILIHAAVMTKPKVKRSKKGPNS
uniprot
proteins
ec_number
2.1.1.-
uniprot
proteins
function
FUNCTION: Histone methyltransferase that selectively methylates 'Lys-4' of dimethylated histone H3 (H3K4me2) to produce trimethylated 'Lys-4' histone H3 (H3K4me3). May play a role in epigenetic regulation of gene expression by defining an active chromatin state. {ECO:0000269|PubMed:27129774}.
uniprot
proteins
mass_dalton
55777
uniprot
proteins
mutagenesis
MUTAGEN 289; /note="S->N: Gains the ability to sequentially mono-, di-, and tri-methylate both 'Lys-4' and 'Lys-36' of histone H3, albeit with lower efficiency when compared to PRDM9."; /evidence="ECO:0000269|PubMed:27129774"; MUTAGEN 312; /note="S->W: Gains the ability to sequentially mono-, di-, and tri-methylate both 'Lys-4' and 'Lys-36' of histone H3, albeit with lower efficiency when compared to PRDM9."; /evidence="ECO:0000269|PubMed:27129774"; MUTAGEN 357; /note="S->Y: Substantially increases histone-lysine N-methyltransferase activity. Gains the catalytic competency of PRDM9. Sequentially mono-, di-, and tri-methylates both 'Lys-4' and 'Lys-36' of histone H3."; /evidence="ECO:0000269|PubMed:27129774
uniprot
proteins
pubmed
10668202
uniprot
proteins
pubmed
14759258
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17916234
uniprot
proteins
pubmed
27129774
uniprot
proteins
sequence_length
492
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Chromosome {ECO:0000305}.
uniprot
proteins