Plin5
entrez
501283
canonical
uniprot
M0R7Z9
canonical
ensembl
ENSRNOG00000047860
resolver
ensembl
ENSRNOG00055015060
resolver
ensembl
ENSRNOG00060018792
resolver
ensembl
ENSRNOG00065013545
resolver
ensp
ENSRNOP00000065588
resolver
ensp
ENSRNOP00000111121
resolver
ensp
ENSRNOP00055021017
resolver
ensp
ENSRNOP00060026396
resolver
ensp
ENSRNOP00065017270
resolver
enst
ENSRNOT00000073930
resolver
enst
ENSRNOT00000125167
resolver
enst
ENSRNOT00055025754
resolver
enst
ENSRNOT00060032386
resolver
enst
ENSRNOT00065022265
resolver
genesymbol
Plin5
resolver
genesymbol_syn
Lsdp5
resolver
genesymbol_syn
Oxpat
resolver
uniprot
A0ABK0M654
resolver
uniprot_entry
A0ABK0M654_RAT
resolver
uniprot_entry
PLIN5_RAT
resolver
amino_acid_sequence
MDQRGKDTTLALHSRMSGDQTAQDPGSSLGELDQHNVVKRVVALPLVRATCTAVSGAYNSAKDRHPLLGSACRFAEHCVCSVATCALDHAQPLLEHLQPKLATVNDLACRGLDKLEEKLPFLQQPSDTVVTSAKDAVAKSVTGVVDLAQRGRRWSGELRRSVSQAMDTVLRRSVSQAMDTVLGKSEELVDHFLPMTEAELVALATESQGPEVGSVEEQRQKQGYFVRLGSLSARLRHLAYQHSLGKLRESKHRTQEMLAQLQKTLELIQHMQSRASPTPTFHHPKVQELCGDWSPCLENGYRHSQVELETLALSRSLTLELQSAVDALAGCVRGLPPSAQAKVAEVQRSVDALQATFADAHCLGDVAPTALAEGQDSVAQAHACVDEFLDLVLRAMPLAWLVGPFAPILVERSEPLINLATCVDEVVGDPDPRWAHMDWPAQQRAWEAEPADPGGQEAEPPLGQVKHTMMPELDF
uniprot
proteins
function
FUNCTION: Lipid droplet-associated protein that maintains the balance between lipogenesis and lipolysis and also regulates fatty acid oxidation in oxidative tissues. Recruits mitochondria to the surface of lipid droplets and is involved in lipid droplet homeostasis by regulating both the storage of fatty acids in the form of triglycerides and the release of fatty acids for mitochondrial fatty acid oxidation. In lipid droplet triacylglycerol hydrolysis, plays a role as a scaffolding protein for three major key lipolytic players: ABHD5, PNPLA2 and LIPE. Reduces the triacylglycerol hydrolase activity of PNPLA2 by recruiting and sequestering PNPLA2 to lipid droplets. Phosphorylation by PKA enables lipolysis probably by promoting release of ABHD5 from the perilipin scaffold and by facilitating interaction of ABHD5 with PNPLA2. Also increases lipolysis through interaction with LIPE and upon PKA-mediated phosphorylation of LIPE. {ECO:0000269|PubMed:21885430, ECO:0000269|PubMed:22127648, ECO:0000269|PubMed:23353597}.
uniprot
proteins
mass_dalton
51805
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by PKA. Phosphorylated on serine in skeletal muscle at rest or upon lipolytic stimulation. {ECO:0000269|PubMed:24303154}.
uniprot
proteins
protein_family
Perilipin family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
21885430
uniprot
proteins
pubmed
22127648
uniprot
proteins
pubmed
23353597
uniprot
proteins
pubmed
23408028
uniprot
proteins
pubmed
24303154
uniprot
proteins
sequence_length
475
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Lipid droplet {ECO:0000269|PubMed:21885430, ECO:0000269|PubMed:22127648}. Cytoplasm {ECO:0000250|UniProtKB:Q8BVZ1}. Mitochondrion {ECO:0000269|PubMed:21885430, ECO:0000269|PubMed:22127648}. Note=Lipid droplet surface-associated. Exchanges between lipid droplets and the cytoplasm. {ECO:0000250|UniProtKB:Q8BVZ1}.
uniprot
proteins