STRN3
entrez
29966
canonical
uniprot
Q13033
canonical
ensembl
ENSG00000196792
resolver
ensp
ENSP00000347909
resolver
ensp
ENSP00000350071
resolver
genesymbol
STRN3
resolver
genesymbol_syn
GS2NA
resolver
genesymbol_syn
SG2NA
resolver
hgnc
HGNC:15720
resolver
uniprot
A2RTX7
resolver
uniprot
A6NHZ7
resolver
uniprot
Q9NRA5
resolver
uniprot_entry
STRN3_HUMAN
resolver
uniprot_sec
A2RTX7
resolver
uniprot_sec
A6NHZ7
resolver
uniprot_sec
Q9NRA5
resolver
amino_acid_sequence
MDELAGGGGGGPGMAAPPRQQQGPGGNLGLSPGGNGAAGGGGPPASEGAGPAAGPELSRPQQYTIPGILHYIQHEWARFEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLRQYLQEVGYTDTILDVRSQRVRSLLGLSNSEPNGSVETKNLEQILNGGESPKQKGQEIKRSSGDVLETFNFLENADDSDEDEENDMIEGIPEGKDKHRMNKHKIGNEGLAADLTDDPDTEEALKEFDFLVTAEDGEGAGEARSSGDGTEWDKDDLSPTAEVWDVDQGLISKLKEQYKKERKGKKGVKRANRTKLYDMIADLGDDELPHIPSGIINQSRSASTRMTDHEGARAEEAEPITFPSGGGKSFIMGSDDVLLSVLGLGDLADLTVTNDADYSYDLPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVFV
uniprot
proteins
function
FUNCTION: Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753, PubMed:30622739, PubMed:33633399). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable). {ECO:0000269|PubMed:18782753, ECO:0000269|PubMed:30622739, ECO:0000269|PubMed:33633399, ECO:0000305|PubMed:26876214}.
uniprot
proteins
mass_dalton
87209
uniprot
proteins
mutagenesis
MUTAGEN 176..185; /note="RQLLRQYLQE->AQLLRQYLQA: Loss of STRIPAK complex formation."; /evidence="ECO:0000269|PubMed:30622739"; MUTAGEN 179..186; /note="LRQYLQEV->DRQYLQED: Loss of STRIPAK complex formation."; /evidence="ECO:0000269|PubMed:30622739"; MUTAGEN 530; /note="R->E: Decreased interaction with other components of STRIPAK core complex."; /evidence="ECO:0000269|PubMed:33633399
uniprot
proteins
protein_family
WD repeat striatin family
uniprot
proteins
pubmed
10748158
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16964243
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18782753
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25743393
uniprot
proteins
pubmed
26876214
uniprot
proteins
pubmed
30622739
uniprot
proteins
pubmed
33633399
uniprot
proteins
pubmed
7864889
uniprot
proteins
sequence_length
797
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305|PubMed:18782753}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
uniprot
proteins