Mettl17
entrez
52535
canonical
uniprot
Q3U2U7
canonical
ensembl
ENSMUSG00000004561
resolver
ensp
ENSMUSP00000047720
resolver
enst
ENSMUST00000047899
resolver
genesymbol
Mettl17
resolver
genesymbol_syn
D14Ertd209e
resolver
uniprot
B2RSP2
resolver
uniprot_entry
MET17_MOUSE
resolver
uniprot_sec
B2RSP2
resolver
amino_acid_sequence
MATARTPRFLLLFCRSCRSLRGPQSRAYAALVPGVSQVDNGSDFLGKKPHRKHPGILHLPHVQLPQALADAAQLMLFERPMRSVEKQVQALTNYLWSRHLPVEPEELQRRAAYLEKKFLEKQDSAPTEEKLREAVLHALRKTTYHWQELSYSEELSLIYMAARLDGGFAAVFRAFHEIQARIPEFRPQTLMDFGSGTGSVAWAAHRTWGQSLREYVCVDSSAAMLGLAEKLLKGGSESGKPCIPGVFFRQFLPVSPKVQFDVVVSAYALSELPSRADRIEVIQNLWRKTSHFLVLVENGTKAGHRLLMDARNLVLGEKEKSPLDLRPSFVFAPCPHELPCPQLNASKSLACSFSQAYHPIPFNWNKKPKEEIFSMVILARGSPKEANRWPRITQPVLKRPRHVHCHLCCPDGHMQHAVVTARRHGRDLYRCARVSSWGDLLPVIAPSEFPPSSPDEEPPEN
uniprot
proteins
function
FUNCTION: Mitochondrial ribosome (mitoribosome) assembly factor (PubMed:31487196). Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body (By similarity). Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity (By similarity). {ECO:0000250|UniProtKB:Q9H7H0, ECO:0000269|PubMed:31487196}.
uniprot
proteins
mass_dalton
52061
uniprot
proteins
mutagenesis
MUTAGEN 194..198; /note="GSGTG->ASATA: Abolished S-adenosyl-L-methionine-binding and ability to stabilize the small subunits of mitochondrial ribosome."; /evidence="ECO:0000269|PubMed:31487196
uniprot
proteins
protein_family
Methyltransferase superfamily
uniprot
proteins
protein_family
Rsm22 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
31487196
uniprot
proteins
sequence_length
461
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000269|PubMed:31487196}.
uniprot
proteins