Pcdh15
entrez
11994
canonical
uniprot
Q99PJ1
canonical
ensembl
ENSMUSG00000052613
resolver
ensp
ENSMUSP00000090076
resolver
ensp
ENSMUSP00000101064
resolver
ensp
ENSMUSP00000101069
resolver
ensp
ENSMUSP00000117731
resolver
ensp
ENSMUSP00000119662
resolver
ensp
ENSMUSP00000120056
resolver
ensp
ENSMUSP00000121939
resolver
ensp
ENSMUSP00000122466
resolver
ensp
ENSMUSP00000122911
resolver
ensp
ENSMUSP00000122940
resolver
ensp
ENSMUSP00000135501
resolver
ensp
ENSMUSP00000135849
resolver
ensp
ENSMUSP00000141792
resolver
ensp
ENSMUSP00000141920
resolver
ensp
ENSMUSP00000141973
resolver
ensp
ENSMUSP00000142173
resolver
ensp
ENSMUSP00000172634
resolver
genesymbol
Pcdh15
resolver
uniprot
D6RCH0
resolver
uniprot
E9Q7D7
resolver
uniprot
E9Q7R1
resolver
uniprot
E9Q7R2
resolver
uniprot
F6KJX4
resolver
uniprot
F6KKG6
resolver
uniprot
F6R5Z7
resolver
uniprot
F6RBV2
resolver
uniprot
F6U3Q6
resolver
uniprot
F6UPC9
resolver
uniprot
F6VPR3
resolver
uniprot
F6WUN7
resolver
uniprot
F6X715
resolver
uniprot
F6XPA1
resolver
uniprot
F6Y0A5
resolver
uniprot
F6YP25
resolver
uniprot
F6YZQ9
resolver
uniprot
F7ASH0
resolver
uniprot
F7CIN1
resolver
uniprot
F7D5J8
resolver
uniprot
F7DFU0
resolver
uniprot
F8VQ61
resolver
uniprot
H3BKS0
resolver
uniprot
Q0ZM15
resolver
uniprot
Q0ZM16
resolver
uniprot
Q0ZM18
resolver
uniprot
Q0ZM19
resolver
uniprot
Q0ZM20
resolver
uniprot
Q0ZM21
resolver
uniprot
Q0ZM22
resolver
uniprot
Q0ZM23
resolver
uniprot
Q0ZM24
resolver
uniprot
Q0ZM25
resolver
uniprot
Q0ZM26
resolver
uniprot
Q0ZM27
resolver
uniprot
Q0ZM28
resolver
uniprot
Q0ZM29
resolver
uniprot
Q0ZM30
resolver
uniprot
Q0ZM31
resolver
uniprot
Q0ZM32
resolver
uniprot
Q0ZM33
resolver
uniprot
Q0ZM34
resolver
uniprot
Q0ZM35
resolver
uniprot
Q0ZM37
resolver
uniprot
Q2VQG7
resolver
uniprot
Q3URZ1
resolver
uniprot
Q3UTS7
resolver
uniprot_entry
PCD15_MOUSE
resolver
uniprot_sec
D6RCH0
resolver
uniprot_sec
E9Q7D7
resolver
uniprot_sec
E9Q7R1
resolver
uniprot_sec
E9Q7R2
resolver
uniprot_sec
F6KJX4
resolver
uniprot_sec
F6KKG6
resolver
uniprot_sec
F6R5Z7
resolver
uniprot_sec
F6RBV2
resolver
uniprot_sec
F6U3Q6
resolver
uniprot_sec
F6UPC9
resolver
uniprot_sec
F6VPR3
resolver
uniprot_sec
F6WUN7
resolver
uniprot_sec
F6X715
resolver
uniprot_sec
F6XPA1
resolver
uniprot_sec
F6Y0A5
resolver
uniprot_sec
F6YP25
resolver
uniprot_sec
F6YZQ9
resolver
uniprot_sec
F7ASH0
resolver
uniprot_sec
F7CIN1
resolver
uniprot_sec
F7D5J8
resolver
uniprot_sec
F7DFU0
resolver
uniprot_sec
F8VQ61
resolver
uniprot_sec
H3BKS0
resolver
uniprot_sec
Q0ZM15
resolver
uniprot_sec
Q0ZM16
resolver
uniprot_sec
Q0ZM18
resolver
uniprot_sec
Q0ZM19
resolver
uniprot_sec
Q0ZM20
resolver
uniprot_sec
Q0ZM21
resolver
uniprot_sec
Q0ZM22
resolver
uniprot_sec
Q0ZM23
resolver
uniprot_sec
Q0ZM24
resolver
uniprot_sec
Q0ZM25
resolver
uniprot_sec
Q0ZM26
resolver
uniprot_sec
Q0ZM27
resolver
uniprot_sec
Q0ZM28
resolver
uniprot_sec
Q0ZM29
resolver
uniprot_sec
Q0ZM30
resolver
uniprot_sec
Q0ZM31
resolver
uniprot_sec
Q0ZM32
resolver
uniprot_sec
Q0ZM33
resolver
uniprot_sec
Q0ZM34
resolver
uniprot_sec
Q0ZM35
resolver
uniprot_sec
Q0ZM37
resolver
uniprot_sec
Q2VQG7
resolver
uniprot_sec
Q3URZ1
resolver
uniprot_sec
Q3UTS7
resolver
amino_acid_sequence
MFLQFAVWKCLPHGILIASLLVVSWGQYDDDWQYEDCKLARGGPPATIVAIDEESRNGTILVDNMLIKGTAGGPDPTIELSLKDNVDYWVLLDPVKQMLFLNSTGRVLDRDPPMNIHSIVVQVQCVNKKVGTVIYHEVRIVVRDRNDNSPTFKHESYYATVNELTPVGTTIFTGFSGDNGATDIDDGPNGQIEYVIQYNPEDPTSNDTFEIPLMLTGNVVLRKRLNYEDKTRYYVIIQANDRAQNLNERRTTTTTLTVDVLDGDDLGPMFLPCVLVPNTRDCRPLTYQAAIPELRTPEELNPILVTPPIQAIDQDRNIQPPSDRPGILYSILVGTPEDYPRFFHMHPRTAELTLLEPVNRDFHQKFDLVIKAEQDNGHPLPAFASLHIEILDENNQSPYFTMPSYQGYILESAPVGATISESLNLTTPLRIVALDKDIEDTKDPELHLFLNDYTSVFTVTPTGITRYLTLLQPVDREEQQTYTFLITAFDGVQESEPVVVNIRVMDANDNTPTFPEISYDVYVYTDMSPGDSVIQLTAVDADEGSNGEISYEILVGGKGDFVINKTTGLVSIAPGVELIVGQTYALTVQASDNAPPAERRHSICTVYIEVLPPNNQSPPRFPQLMYSLEVSEAMRIGAILLNLQATDREGDPITYAIENGDPQRVFNLSETTGILSLGKALDRESTDRYILIVTASDGRPDGTSTATVNIVVTDVNDNAPVFDPYLPRNLSVVEEEANAFVGQVRATDPDAGINGQVHYSLGNFNNLFRITSNGSIYTAVKLNREARDHYELVVVATDGAVHPRHSTLTLYIKVLDIDDNSPVFTNSTYTVVVEENLPAGTSFLQIEAKDVDLGANVSYRIRSPEVKHLFALHPFTGELSLLRSLDYEAFPDQEASITFLVEAFDIYGTMPPGIATVTVIVKDMNDYPPVFSKRIYKGMVAPDAVKGTPITTVYAEDADPPGMPASRVRYRVDDVQFPYPASIFDVEEDSGRVVTRVNLNEEPTTIFKLVVVAFDDGEPVMSSSATVRILVLHPGEIPRFTQEEYRPPPVSELAARGTVVGVISAAAINQSIVYSIVAGNEEDKFGINNVTGVIYVNSPLDYETRTSYVLRVQADSLEVVLANLRVPSKSNTAKVYIEIQDENDHPPVFQKKFYIGGVSEDARMFASVLRVKATDRDTGNYSAMAYRLIIPPIKEGKEGFVVETYTGLIKTAMLFHNMRRSYFKFQVIATDDYGKGLSGKADVLVSVVNQLDMQVIVSNVPPTLVEKKIEDLTEILDRYVQEQIPGAKVVVESIGARRHGDAYSLEDYSKCDLTVYAIDPQTNRAIDRNELFKFLDGKLLDINKDFQPYYGEGGRILEIRTPEAVTSIKKRGESLGYTEGALLALAFIIILCCIPAILVVLVSYRQFKVRQAECTKTARIQSAMPAAKPAAPVPAAPAPPPPPPPPPPGAHLYEELGESAMHNLFLLYHFEQSRGNNSVPEDRSSHRDGMAFSSSTTESHEPAHVEGPLKESQPNPARTFSFVPDEDNLSTHNPLYMESIGQRSTNSDLQPRTDFEELLAPRTQVKSQSLRGPREKIQRVWNQSVSFPRRLMWKAPNRPETIDLVEWQITNQRAECESARCHPSQRGSSNVLLATEDAHESEKEGGHRDTLIVQQTEQLKSLSSGSSFSSSWSHFSFSTLPTISRAVELGSEPNVVTSPADCTLELSPPLRPRILNSLSSKRETPTCASDTEPKRNSFEIAPHPPSISAPLPHPPLPRPPIAFTTFPLPLSPPNPPPPQLVTFSLPISTPPTSSLPLPPPLSLPPPPRPPAPRLFPQPPSTSIPSTDSISAPAAKCTASATHARETTSTTQPPASNPQWGAEPHRHPKGILRHVKNLAELEKSVSNMYSHIEKNCPPADPSKLHTFCPAEKTGMKITHDQSQETLVRVVEGIDVQPHSQSTSL
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Pcdh15 are the cause of the Ames waltzer (av) phenotype. It is characterized by deafness and a balance disorder, associated with the degeneration of inner ear neuroepithelia.
uniprot
proteins
function
FUNCTION: Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function.
uniprot
proteins
mass_dalton
214738
uniprot
proteins
mutagenesis
MUTAGEN 48; /note="I->A: Strongly reduced interaction with CDH23."; /evidence="ECO:0000269|PubMed:23135401"; MUTAGEN 139; /note="R->G: Impaired interaction with CDH23."; /evidence="ECO:0000269|PubMed:23135401
uniprot
proteins
pubmed
11138007
uniprot
proteins
pubmed
11429292
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16481439
uniprot
proteins
pubmed
16799054
uniprot
proteins
pubmed
16807332
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17805295
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21436032
uniprot
proteins
pubmed
23135401
uniprot
proteins
pubmed
23217710
uniprot
proteins
pubmed
25114259
uniprot
proteins
pubmed
25467981
uniprot
proteins
pubmed
28504928
uniprot
proteins
pubmed
38228630
uniprot
proteins
sequence_length
1943
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:21436032, ECO:0000269|PubMed:23217710}; Single-pass membrane protein {ECO:0000269|PubMed:21436032, ECO:0000269|PubMed:23217710}. Note=Efficient localization to the plasma membrane requires the presence of LHFPL5.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 3]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 5]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 6]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 7]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 8]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 9]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 10]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 11]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 12]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 13]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 14]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 15]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 16]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 17]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 18]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 19]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.; SUBCELLULAR LOCATION: [Isoform 21]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 22]: Secreted {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform 23]: Secreted {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 1382..1402; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins