AIF1
entrez
199
canonical
uniprot
P55008
canonical
ensembl
ENSG00000204472
resolver
ensembl
ENSG00000206428
resolver
ensembl
ENSG00000234836
resolver
ensembl
ENSG00000235588
resolver
ensembl
ENSG00000235985
resolver
ensembl
ENSG00000237727
resolver
ensp
ENSP00000365217
resolver
ensp
ENSP00000365227
resolver
genesymbol
AIF1
resolver
genesymbol_syn
G1
resolver
genesymbol_syn
IBA1
resolver
hgnc
HGNC:352
resolver
uniprot
A8K406
resolver
uniprot
I3WTX1
resolver
uniprot
O43904
resolver
uniprot
Q4V347
resolver
uniprot
Q9UIV4
resolver
uniprot
Q9UKS9
resolver
uniprot_entry
AIF1_HUMAN
resolver
uniprot_entry
I3WTX1_HUMAN
resolver
uniprot_entry
Q4V347_HUMAN
resolver
uniprot_sec
A8K406
resolver
uniprot_sec
O43904
resolver
uniprot_sec
Q9UIV4
resolver
uniprot_sec
Q9UKS9
resolver
amino_acid_sequence
MSQTRDLQGGKAFGLLKAQQEERLDEINKQFLDDPKYSSDEDLPSKLEGFKEKYMEFDLNGNGDIDIMSLKRMLEKLGVPKTHLELKKLIGEVSSGSGETFSYPDFLRMMLGKRSAILKMILMYEEKAREKEKPTGPPAKKAISELP
uniprot
proteins
function
FUNCTION: Actin-binding protein that enhances membrane ruffling and RAC activation. Enhances the actin-bundling activity of LCP1. Binds calcium. Plays a role in RAC signaling and in phagocytosis. May play a role in macrophage activation and function. Promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes. Enhances lymphocyte migration. Plays a role in vascular inflammation. {ECO:0000269|PubMed:15117732, ECO:0000269|PubMed:16049345, ECO:0000269|PubMed:18699778}.
uniprot
proteins
mass_dalton
16703
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine residues.
uniprot
proteins
pubmed
10202016
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14656967
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15117732
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16049345
uniprot
proteins
pubmed
17011575
uniprot
proteins
pubmed
18699778
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
7590964
uniprot
proteins
pubmed
8081366
uniprot
proteins
pubmed
8629302
uniprot
proteins
pubmed
8912632
uniprot
proteins
pubmed
9367684
uniprot
proteins
sequence_length
147
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:O70200}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:O70200}; Peripheral membrane protein {ECO:0000250|UniProtKB:O70200}; Cytoplasmic side {ECO:0000250|UniProtKB:O70200}. Cell projection, phagocytic cup {ECO:0000250|UniProtKB:O70200}. Note=Associated with the actin cytoskeleton at membrane ruffles and at sites of phagocytosis. {ECO:0000250|UniProtKB:O70200}.
uniprot
proteins