Gdf5
entrez
14563
canonical
uniprot
P43027
canonical
ensembl
ENSMUSG00000038259
resolver
ensp
ENSMUSP00000048079
resolver
enst
ENSMUST00000040162
resolver
genesymbol
Gdf5
resolver
genesymbol_syn
Bmp14
resolver
genesymbol_syn
Bp
resolver
genesymbol_syn
Gdf-5
resolver
uniprot
A2ARK2
resolver
uniprot
Q8BRW9
resolver
uniprot_entry
GDF5_MOUSE
resolver
uniprot_entry
Q8BRW9_MOUSE
resolver
uniprot_sec
A2ARK2
resolver
amino_acid_sequence
MRLPKLLTLLLWHLAWLDLELICTVLGAPDLGQRTPGAKPGLTKAEAKERPPLARNVFRPGGHIYGVGATNARAKGSSGQTQAKKDEPRKMPPRSGGPETKPGPSSQTRQAAARTVTPKGQLPGGKASSKAGSAPSSFLLKKTREPGTPREPKEPFRPPPITPHEYMLSLYRTLSDADRKGGNSSVKLEAGLANTITSFIDKGQDDRGPAVRKQRYVFDISALEKDGLLGAELRILRKKPLDVAKPAVPSSGRVAQLKLSSCPSGRQPAALLDVRSVPGLDGSGWEVFDIWKLFRNFKNSAQLCLELEAWERGRAVDLRGLGFERTARQVHEKALFLVFGRTKKRDLFFNEIKARSGQDDKTVYEYLFSQRRKRRAPLANRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Gdf5 are the cause of brachypodism (bp) which alters the length and numbers of bones in the limbs but spares the axial skeleton. {ECO:0000269|PubMed:8145850}.
uniprot
proteins
function
FUNCTION: Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction (By similarity). Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG (By similarity). Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8 (PubMed:24076600). Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes (By similarity). {ECO:0000250|UniProtKB:P43026, ECO:0000269|PubMed:24076600}.
uniprot
proteins
mass_dalton
54895
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
14973287
uniprot
proteins
pubmed
15206957
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
24076600
uniprot
proteins
pubmed
8145850
uniprot
proteins
sequence_length
495
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P43026}. Cell membrane {ECO:0000250|UniProtKB:P43026}.
uniprot
proteins