AMTN
entrez
401138
canonical
uniprot
Q6UX39
canonical
ensembl
ENSG00000187689
resolver
ensp
ENSP00000341013
resolver
ensp
ENSP00000422452
resolver
genesymbol
AMTN
resolver
hgnc
HGNC:33188
resolver
uniprot
F1T0L8
resolver
uniprot
Q0P503
resolver
uniprot
Q0P506
resolver
uniprot_entry
AMTN_HUMAN
resolver
uniprot_entry
F1T0L8_HUMAN
resolver
uniprot_sec
Q0P503
resolver
uniprot_sec
Q0P506
resolver
amino_acid_sequence
MRSTILLFCLLGSTRSLPQLKPALGLPPTKLAPDQGTLPNQQQSNQVFPSLSLIPLTQMLTLGPDLHLLNPAAGMTPGTQTHPLTLGGLNVQQQLHPHVLPIFVTQLGAQGTILSSEELPQIFTSLIIHSLFPGGILPTSQAGANPDVQDGSLPAGGAGVNPATQGTPAGRLPTPSGTDDDFAVTTPAGIQRSTHAIEEATTESANGIQ
uniprot
proteins
disease_involvement
DISEASE: Amelogenesis imperfecta 3B (AI3B) [MIM:617607]: An autosomal dominant form of amelogenesis imperfecta, a defect of enamel formation. AI3B is characterized by hypomineralized enamel that has reduced tickness and exhibits structural defects. {ECO:0000269|PubMed:27412008}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Is a promoter of calcium phosphate mineralization, playing a critical role in the formation of the compact, mineralized, aprismatic enamel surface layer during the maturation stage of amelogenesis. {ECO:0000269|PubMed:25407797}.
uniprot
proteins
mass_dalton
21588
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by FAM20C in vitro. {ECO:0000269|PubMed:25789606}.; PTM: O-glycosylated. {ECO:0000250|UniProtKB:Q3HS82}.
uniprot
proteins
protein_family
Amelotin family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15340161
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
25407797
uniprot
proteins
pubmed
25789606
uniprot
proteins
pubmed
27412008
uniprot
proteins
sequence_length
209
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:Q9D3J8}.
uniprot
proteins