MED15
entrez
51586
canonical
uniprot
Q96RN5
canonical
ensembl
ENSG00000099917
resolver
ensp
ENSP00000263205
resolver
ensp
ENSP00000292733
resolver
ensp
ENSP00000372434
resolver
ensp
ENSP00000384344
resolver
ensp
ENSP00000523271
resolver
ensp
ENSP00000523272
resolver
ensp
ENSP00000796219
resolver
ensp
ENSP00000796220
resolver
enst
ENST00000406969
resolver
genesymbol
MED15
resolver
genesymbol_syn
ARC105
resolver
genesymbol_syn
CTG7A
resolver
genesymbol_syn
PCQAP
resolver
genesymbol_syn
TIG1
resolver
genesymbol_syn
TNRC7
resolver
hgnc
HGNC:14248
resolver
uniprot
B3KWF1
resolver
uniprot
B7Z2H7
resolver
uniprot
D3DX31
resolver
uniprot
D3DX32
resolver
uniprot
G3V1P5
resolver
uniprot
O15413
resolver
uniprot
Q6IC31
resolver
uniprot
Q6PKB8
resolver
uniprot
Q8NF16
resolver
uniprot
Q96CT0
resolver
uniprot
Q96IH7
resolver
uniprot
Q9P1T3
resolver
uniprot_entry
B3KWF1_HUMAN
resolver
uniprot_entry
B7Z2H7_HUMAN
resolver
uniprot_entry
G3V1P5_HUMAN
resolver
uniprot_entry
MED15_HUMAN
resolver
uniprot_entry
Q6PKB8_HUMAN
resolver
uniprot_sec
D3DX31
resolver
uniprot_sec
D3DX32
resolver
uniprot_sec
O15413
resolver
uniprot_sec
Q6IC31
resolver
uniprot_sec
Q8NF16
resolver
uniprot_sec
Q96CT0
resolver
uniprot_sec
Q96IH7
resolver
uniprot_sec
Q9P1T3
resolver
amino_acid_sequence
MDVSGQETDWRSTAFRQKLVSQIEDAMRKAGVAHSKSSKDMESHVFLKAKTRDEYLSLVARLIIHFRDIHNKKSQASVSDPMNALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPVAQNQPSQLPPQSQTQPLVSQAQALPGQMLYTQPPLKFVRAPMVVQQPPVQPQVQQQQTAVQTAQAAQMVAPGVQMITEALAQGGMHIRARFPPTTAVSAIPSSSIPLGRQPMAQVSQSSLPMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPSPSSFLPSPSPQPSQSPVTARTPQNFSVPSPGPLNTPVNPSSVMSPAGSSQAEEQQYLDKLKQLSKYIEPLRRMINKIDKNEDRKKDLSKMKSLLDILTDPSKRCPLKTLQKCEIALEKLKNDMAVPTPPPPPVPPTKQQYLCQPLLDAVLANIRSPVFNHSLYRTFVPAMTAIHGPPITAPVVCTRKRRLEDDERQSIPSVLQGEVARLDPKFLVNLDPSHCSNNGTVHLICKLDDKDLPSVPPLELSVPADYPAQSPLWIDRQWQYDANPFLQSVHRCMTSRLLQLPDKHSVTALLNTWAQSVHQACLSAA
uniprot
proteins
function
FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway. {ECO:0000269|PubMed:12167862, ECO:0000269|PubMed:16630888, ECO:0000269|PubMed:16799563}.
uniprot
proteins
mass_dalton
86753
uniprot
proteins
mutagenesis
MUTAGEN 42; /note="E->A: Abrogates interaction with SREBF1."; /evidence="ECO:0000269|PubMed:16799563"; MUTAGEN 58; /note="L->D: Abrogates interaction with SREBF1."; /evidence="ECO:0000269|PubMed:16799563"; MUTAGEN 60; /note="A->D: Abrogates interaction with SREBF1."; /evidence="ECO:0000269|PubMed:16799563
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by TRIM11, leading to proteasomal degradation. {ECO:0000269|PubMed:16904669}.
uniprot
proteins
protein_family
Mediator complex subunit 15 family
uniprot
proteins
pubmed
10235267
uniprot
proteins
pubmed
11024300
uniprot
proteins
pubmed
11414760
uniprot
proteins
pubmed
12167862
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15175163
uniprot
proteins
pubmed
15461802
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15989967
uniprot
proteins
pubmed
16630888
uniprot
proteins
pubmed
16799563
uniprot
proteins
pubmed
16904669
uniprot
proteins
pubmed
18568018
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9225980
uniprot
proteins
sequence_length
788
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
uniprot
proteins