MAJN
entrez
399687
canonical
uniprot
Q92614
canonical
ensembl
ENSG00000196535
resolver
ensp
ENSP00000434228
resolver
ensp
ENSP00000435932
resolver
ensp
ENSP00000437073
resolver
ensp
ENSP00000515984
resolver
enst
ENST00000704659
resolver
genesymbol
MAJN
resolver
genesymbol
MYO18A
resolver
genesymbol_syn
CD245
resolver
genesymbol_syn
KIAA0216
resolver
genesymbol_syn
MYSPDZ
resolver
genesymbol_syn
TIAF1
resolver
hgnc
HGNC:31104
resolver
uniprot
A0A994J771
resolver
uniprot
Q5H9U3
resolver
uniprot
Q5QD01
resolver
uniprot
Q5W9F9
resolver
uniprot
Q5W9G1
resolver
uniprot
Q8IXP8
resolver
uniprot
Q9NYE8
resolver
uniprot_entry
A0A994J771_HUMAN
resolver
uniprot_entry
MY18A_HUMAN
resolver
uniprot_entry
Q9NYE8_HUMAN
resolver
uniprot_sec
Q5H9U3
resolver
uniprot_sec
Q5QD01
resolver
uniprot_sec
Q5W9F9
resolver
uniprot_sec
Q5W9G1
resolver
uniprot_sec
Q8IXP8
resolver
amino_acid_sequence
MFNLMKKDKDKDGGRKEKKEKKEKKERMSAAELRSLEEMSLRRGFFNLNRSSKRESKTRLEISNPIPIKVASGSDLHLTDIDSDSNRGSVILDSGHLSTASSSDDLKGEEGSFRGSVLQRAAKFGSLAKQNSQMIVKRFSFSQRSRDESASETSTPSEHSAAPSPQVEVRTLEGQLVQHPGPGIPRPGHRSRAPELVTKKFPVDLRLPPVVPLPPPTLRELELQRRPTGDFGFSLRRTTMLDRGPEGQACRRVVHFAEPGAGTKDLALGLVPGDRLVEINGHNVESKSRDEIVEMIRQSGDSVRLKVQPIPELSELSRSWLRSGEGPRREPSDAKTEEQIAAEEAWNETEKVWLVHRDGFSLASQLKSEELNLPEGKVRVKLDHDGAILDVDEDDVEKANAPSCDRLEDLASLVYLNESSVLHTLRQRYGASLLHTYAGPSLLVLGPRGAPAVYSEKVMHMFKGCRREDMAPHIYAVAQTAYRAMLMSRQDQSIILLGSSGSGKTTSCQHLVQYLATIAGISGNKVFSVEKWQALYTLLEAFGNSPTIINGNATRFSQILSLDFDQAGQVASASIQTMLLEKLRVARRPASEATFNVFYYLLACGDGTLRTELHLNHLAENNVFGIVPLAKPEEKQKAAQQFSKLQAAMKVLGISPDEQKACWFILAAIYHLGAAGATKEAAEAGRKQFARHEWAQKAAYLLGCSLEELSSAIFKHQHKGGTLQRSTSFRQGPEESGLGDGTGPKLSALECLEGMAAGLYSELFTLLVSLVNRALKSSQHSLCSMMIVDTPGFQNPEQGGSARGASFEELCHNYTQDRLQRLFHERTFVQELERYKEENIELAFDDLEPPTDDSVAAVDQASHQSLVRSLARTDEARGLLWLLEEEALVPGASEDTLLERLFSYYGPQEGDKKGQSPLLHSSKPHHFLLGHSHGTNWVEYNVTGWLNYTKQNPATQNAPRLLQDSQKKIISNLFLGRAGSATVLSGSIAGLEGGSQLALRRATSMRKTFTTGMAAVKKKSLCIQMKLQVDALIDTIKKSKLHFVHCFLPVAEGWAGEPRSASSRRVSSSSELDLPSGDHCEAGLLQLDVPLLRTQLRGSRLLDAMRMYRQGYPDHMVFSEFRRRFDVLAPHLTKKHGRNYIVVDERRAVEELLECLDLEKSSCCMGLSRVFFRAGTLARLEEQRDEQTSRNLTLFQAACRGYLARQHFKKRKIQDLAIRCVQKNIKKNKGVKDWPWWKLFTTVRPLIEVQLSEEQIRNKDEEIQQLRSKLEKAEKERNELRLNSDRLESRISELTSELTDERNTGESASQLLDAETAERLRAEKEMKELQTQYDALKKQMEVMEMEVMEARLIRAAEINGEVDDDDAGGEWRLKYERAVREVDFTKKRLQQEFEDKLEVEQQNKRQLERRLGDLQADSEESQRALQQLKKKCQRLTAELQDTKLHLEGQQVRNHELEKKQRRFDSELSQAHEEAQREKLQREKLQREKDMLLAEAFSLKQQLEEKDMDIAGFTQKVVSLEAELQDISSQESKDEASLAKVKKQLRDLEAKVKDQEEELDEQAGTIQMLEQAKLRLEMEMERMRQTHSKEMESRDEEVEEARQSCQKKLKQMEVQLEEEYEDKQKVLREKRELEGKLATLSDQVNRRDFESEKRLRKDLKRTKALLADAQLMLDHLKNSAPSKREIAQLKNQLEESEFTCAAAVKARKAMEVEIEDLHLQIDDIAKAKTALEEQLSRLQREKNEIQNRLEEDQEDMNELMKKHKAAVAQASRDLAQINDLQAQLEEANKEKQELQEKLQALQSQVEFLEQSMVDKSLVSRQEAKIRELETRLEFERTQVKRLESLASRLKENMEKLTEERDQRIAAENREKEQNKRLQRQLRDTKEEMGELARKEAEASRKKHELEMDLESLEAANQSLQADLKLAFKRIGDLQAAIEDEMESDENEDLINSLQDMVTKYQKRKNKLEGDSDVDSELEDRVDGVKSWLSKNKGPSKAASDDGSLKSSSPTSYWKSLAPDRSDDEHDPLDNTSRPRYSHSYLSDSDTEAKLTETNA
uniprot
proteins
function
FUNCTION: May link Golgi membranes to the cytoskeleton and participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus (PubMed:19837035, PubMed:23345592). Alternatively, in concert with LURAP1 and CDC42BPA/CDC42BPB, has been involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). May be involved in the maintenance of the stromal cell architectures required for cell to cell contact (By similarity). Regulates trafficking, expression, and activation of innate immune receptors on macrophages. Plays a role to suppress inflammatory responsiveness of macrophages via a mechanism that modulates CD14 trafficking (PubMed:25965346). Acts as a receptor of surfactant-associated protein A (SFTPA1/SP-A) and plays an important role in internalization and clearance of SFTPA1-opsonized S.aureus by alveolar macrophages (PubMed:16087679, PubMed:21123169). Strongly enhances natural killer cell cytotoxicity (PubMed:27467939). {ECO:0000250|UniProtKB:Q9JMH9, ECO:0000269|PubMed:16087679, ECO:0000269|PubMed:18854160, ECO:0000269|PubMed:19837035, ECO:0000269|PubMed:21123169, ECO:0000269|PubMed:23345592, ECO:0000269|PubMed:25965346, ECO:0000269|PubMed:27467939}.
uniprot
proteins
mass_dalton
233115
uniprot
proteins
mutagenesis
MUTAGEN 114..115; /note="RG->AA: No effect on interaction with actin."; /evidence="ECO:0000269|PubMed:15835906"; MUTAGEN 117..118; /note="VL->AA: Abolishes interaction with actin."; /evidence="ECO:0000269|PubMed:15835906
uniprot
proteins
protein_family
Myosin family
uniprot
proteins
protein_family
TRAFAC class myosin-kinesin ATPase superfamily
uniprot
proteins
pubmed
10733938
uniprot
proteins
pubmed
12761286
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15491607
uniprot
proteins
pubmed
15835906
uniprot
proteins
pubmed
16087679
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18088087
uniprot
proteins
pubmed
18220336
uniprot
proteins
pubmed
18318008
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18854160
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
19837035
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21123169
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23345592
uniprot
proteins
pubmed
23990465
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25965346
uniprot
proteins
pubmed
27467939
uniprot
proteins
pubmed
9039502
uniprot
proteins
sequence_length
2054
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus {ECO:0000269|PubMed:19837035}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:19837035}. Golgi outpost {ECO:0000250|UniProtKB:D3ZFD0}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000250|UniProtKB:D3ZFD0}. Note=Recruited to the Golgi apparatus by GOLPH3 (PubMed:19837035). Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation (By similarity). {ECO:0000250|UniProtKB:D3ZFD0, ECO:0000269|PubMed:19837035}.; SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250|UniProtKB:Q9JMH9}. Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9JMH9}. Note=Colocalizes with actin. {ECO:0000250|UniProtKB:Q9JMH9}.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:12761286}. Note=Lacks the PDZ domain (PubMed:12761286). Diffusely localized in the cytoplasm (PubMed:12761286). {ECO:0000269|PubMed:12761286}.; SUBCELLULAR LOCATION: [Isoform 5]: Cell surface {ECO:0000269|PubMed:16087679}.
uniprot
proteins