NELFCD
entrez
51497
canonical
uniprot
Q8IXH7
canonical
ensembl
ENSG00000101158
resolver
ensp
ENSP00000473290
resolver
ensp
ENSP00000499018
resolver
ensp
ENSP00000675180
resolver
enst
ENST00000602795
resolver
genesymbol
NELFCD
resolver
genesymbol_syn
NELFD
resolver
genesymbol_syn
TH1
resolver
genesymbol_syn
TH1L
resolver
hgnc
HGNC:15934
resolver
uniprot
B4DE06
resolver
uniprot
H0UI80
resolver
uniprot
H0UI81
resolver
uniprot
Q9BYL2
resolver
uniprot
Q9H405
resolver
uniprot
Q9H888
resolver
uniprot
Q9H8T3
resolver
uniprot
Q9NVX5
resolver
uniprot
Q9P029
resolver
uniprot
Q9UGN1
resolver
uniprot
Q9UGN2
resolver
uniprot
Q9UGN3
resolver
uniprot_entry
H0UI80_HUMAN
resolver
uniprot_entry
NELFD_HUMAN
resolver
uniprot_sec
B4DE06
resolver
uniprot_sec
H0UI81
resolver
uniprot_sec
Q9BYL2
resolver
uniprot_sec
Q9H405
resolver
uniprot_sec
Q9H888
resolver
uniprot_sec
Q9H8T3
resolver
uniprot_sec
Q9NVX5
resolver
uniprot_sec
Q9P029
resolver
uniprot_sec
Q9UGN1
resolver
uniprot_sec
Q9UGN2
resolver
uniprot_sec
Q9UGN3
resolver
amino_acid_sequence
MAGAVPGAIMDEDYYGSAAEWGDEADGGQQEDDSGEGEDDAEVQQECLHKFSTRDYIMEPSIFNTLKRYFQAGGSPENVIQLLSENYTAVAQTVNLLAEWLIQTGVEPVQVQETVENHLKSLLIKHFDPRKADSIFTEEGETPAWLEQMIAHTTWRDLFYKLAEAHPDCLMLNFTVKLISDAGYQGEITSVSTACQQLEVFSRVLRTSLATILDGGEENLEKNLPEFAKMVCHGEHTYLFAQAMMSVLAQEEQGGSAVRRIAQEVQRFAQEKGHDASQITLALGTAASYPRACQALGAMLSKGALNPADITVLFKMFTSMDPPPVELIRVPAFLDLFMQSLFKPGARINQDHKHKYIHILAYAASVVETWKKNKRVSINKDELKSTSKAVETVHNLCCNENKGASELVAELSTLYQCIRFPVVAMGVLKWVDWTVSEPRYFQLQTDHTPVHLALLDEISTCHQLLHPQVLQLLVKLFETEHSQLDVMEQLELKKTLLDRMVHLLSRGYVLPVVSYIRKCLEKLDTDISLIRYFVTEVLDVIAPPYTSDFVQLFLPILENDSIAGTIKTEGEHDPVTEFIAHCKSNFIMVN
uniprot
proteins
function
FUNCTION: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:12612062). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:10199401). {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:12612062}.; FUNCTION: (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. {ECO:0000269|PubMed:23884411}.
uniprot
proteins
mass_dalton
66247
uniprot
proteins
mutagenesis
MUTAGEN 291; /note="R->Q: Reduces RNA binding; when associated with M-315, M-371, M-372, M-374, M-384, M-388, Q-419 and Q-506."; /evidence="ECO:0000269|PubMed:27282391"; MUTAGEN 315; /note="K->M: Reduces RNA binding; when associated with Q-291, M-371, M-372, M-374, M-384, M-388, Q-419 and Q-506."; /evidence="ECO:0000269|PubMed:27282391"; MUTAGEN 371; /note="K->M: Reduces RNA binding; when associated with Q-291, M-315, M-372, M-374, M-384, M-388, Q-419 and Q-506."; /evidence="ECO:0000269|PubMed:27282391"; MUTAGEN 372; /note="K->M: Reduces RNA binding; when associated with Q-291, M-315, M-371, M-374, M-384, M-388, Q-419 and Q-506."; /evidence="ECO:0000269|PubMed:27282391"; MUTAGEN 374; /note="K->M: Reduces RNA binding; when associated with Q-291, M-315, M-371, M-372, M-384, M-388, Q-419 and Q-506."; /evidence="ECO:0000269|PubMed:27282391"; MUTAGEN 384; /note="K->M: Reduces RNA binding; when associated with Q-291, M-315, M-371, M-372, M-374, M-388, Q-419 and Q-506."; /evidence="ECO:0000269|PubMed:27282391"; MUTAGEN 388; /note="K->M: Reduces RNA binding; when associated with Q-291, M-315, M-371, M-372, M-374, M-384, Q-419 and Q-506."; /evidence="ECO:0000269|PubMed:27282391"; MUTAGEN 419; /note="R->Q: Reduces RNA binding; when associated with Q-291, M-315, M-371, M-372, M-374, M-384, M-388 and Q-506."; /evidence="ECO:0000269|PubMed:27282391"; MUTAGEN 506; /note="R->Q: Reduces RNA binding; when associated with Q-291, M-315, M-371, M-372, M-374, M-384, M-388 and Q-419."; /evidence="ECO:0000269|PubMed:27282391
uniprot
proteins
protein_family
NELF-D family
uniprot
proteins
pubmed
10199401
uniprot
proteins
pubmed
11030415
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
11780052
uniprot
proteins
pubmed
11952167
uniprot
proteins
pubmed
12612062
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23884411
uniprot
proteins
pubmed
27282391
uniprot
proteins
sequence_length
590
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins