Serbp1
entrez
246303
canonical
uniprot
Q6AXS5
canonical
ensembl
ENSRNOG00000005890
resolver
ensembl
ENSRNOG00055013935
resolver
ensembl
ENSRNOG00060023807
resolver
ensembl
ENSRNOG00065029303
resolver
ensp
ENSRNOP00000086511
resolver
genesymbol
Serbp1
resolver
genesymbol_syn
Pairbp1
resolver
genesymbol_syn
Rda288
resolver
uniprot
Q8VHU3
resolver
uniprot_entry
SERB1_RAT
resolver
uniprot_sec
Q8VHU3
resolver
amino_acid_sequence
MPGHLQEGFGCVVTNRFDQLFDDESDPFEVLKAAENKKKEAGGGGVGGPGAKSAAQAAAQTNSNAAGKQLRKESQKDRKNPLPPSVGVADKKEETQPPVALKKEGIRRVGRRPDQQLQGDGKIIDRRPERRPPRERRFEKPLEEKGEGGEFSVDRPIIERPIRGRGGLGRGRGGRGRGMGRGDGFDSRGKREFDRHSGSDRSSFSHYSGLKHEDKRGGSGSHNWGTVKDELTESPKYIQKQISYNCSDLEQSNVTEETPEGEEHPVADTENKENEVEEVKEEGPKEMTLDEWKAIQNKDRAKVEFNIRKPNEGADGQWKKGFVLHKSKSEEAHAEDSVMDHHFRKPANDITSQLEINFGDLGRPGRGGRGGRGGRGRGGRPNRGSRTDKSSASAPDVDDPEAFPALA
uniprot
proteins
function
FUNCTION: Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation (By similarity). Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state (By similarity). May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. Seems to play a role in PML-nuclear bodies formation (By similarity). {ECO:0000250|UniProtKB:Q8NC51, ECO:0000250|UniProtKB:Q9CY58}.
uniprot
proteins
mass_dalton
44754
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by MTOR inhibits SERBP1 and relieves ribosome hibernation. {ECO:0000250|UniProtKB:Q8NC51}.
uniprot
proteins
protein_family
SERBP1-HABP4 family
uniprot
proteins
pubmed
11001948
uniprot
proteins
pubmed
12112363
uniprot
proteins
pubmed
14988380
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
407
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8NC51}. Nucleus {ECO:0000250|UniProtKB:Q8NC51}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q8NC51}.
uniprot
proteins