Ccdc66
entrez
320234
canonical
uniprot
Q6NS45
canonical
ensembl
ENSMUSG00000046753
resolver
ensp
ENSMUSP00000052546
resolver
ensp
ENSMUSP00000153023
resolver
ensp
ENSMUSP00000281797
resolver
ensp
ENSMUSP00000332912
resolver
genesymbol
Ccdc66
resolver
uniprot
Q3ULU6
resolver
uniprot
Q8C304
resolver
uniprot
Q8C6T6
resolver
uniprot_entry
CCD66_MOUSE
resolver
uniprot_sec
Q3ULU6
resolver
uniprot_sec
Q8C304
resolver
uniprot_sec
Q8C6T6
resolver
amino_acid_sequence
MNLGDGLKLETELLDGKTKLILSPYEHKSKVSVKMGNKFKIAKCPLRTKQTGHTLKSTQNTYIGNENLSQKKISTLDTSQAKPENSRLTFSPSTDKQYSEKDSVRVQKEISPTTSNIRKIINTTGTCPVAKQKPCKKNPTAETMNSGLVCLTQDQLRQILMLSVNQGNGSVCLTETGEEEASQDSLHLINIPSQPKDVNDTGFLQNTEAASPVTSEHEHVHRRAQEAFQQCEQKAATENEWKPADIFSTLGERERDKSLLEARRAQWKKELDEQVALKKKEKEASQKWHNPWKPSDIECEKSQVHDQSKEARLLESPCSAIKQEQQRKWIEELNKQVEDDQQRKAEERMIYSKGEEHDRWAVHFDSLKSHPGSQSRLSSQLTHQHLESLCVSPDTQELADVNGVFTPPPGVQAEPSEKEQRARPVLEMAVSHGPKTNFLRSMTALLDPAQIEERERRRQKQLEHQKAIMAQVEENRRKKRLEEEQRKKEEQELELRLAREREEMQRQYEEDILKQRQREEIMTLKTNELFHTMQRAQELAQRLKQEQRIRELAQKGHDTSRLIQNLGAQVDYKAFTTISSSHSDPEETADTSTASPKKDTGVQTDDVNLGIFNDALPPCGSVTEKGIRNISSPEISAEFSGQTDIRKENQELSMNKGTNLDKENSWHNGQCNQYRRTEKQTKLMKKCPKKPAWNINKPLKKYVPASAKYPAHLQKEKEEKKVQRQMELLHLVERNNPENLSQNRGISPLATSHRETESESRLHLIKKVEEPLKTPSVSKERFQTSPAVKNRTQQTQSNVLHLPLKNNDYEKETLTLGDGHTKLSDEMSEPSHFIPYVRTNEIYYLDPDAPLSRPSTQDNQYQKSHDCAREQELFDSDHIRDPLLNPKLVKNRDRQQAILKGLSELRQGLLQKQKELETNLIPLTANQEDNFSSSF
uniprot
proteins
function
FUNCTION: Microtubule-binding protein required for ciliogenesis. May function in ciliogenesis by mediating the transport of proteins like BBS4 to the cilium, but also through the organization of the centriolar satellites. Required for the assembly of signaling-competent cilia with proper structure and length. Mediates this function in part by regulating transition zone assembly and basal body recruitment of the IFT-B complex. Cooperates with the ciliopathy proteins CSPP1 and CEP104 during cilium length regulation (By similarity). Essential for cilium elongation, maintaining ciliary length and stability, and inhibiting disassembly (likely by stabilizing the axoneme) (PubMed:40729374). Also plays a role in ciliary Hedgehog pathway activation (PubMed:40729374). Plays two important roles during cell division. First, is required for mitotic progression via regulation of spindle assembly, organization and orientation, levels of spindle microtubules (MTs), kinetochore-fiber integrity, and chromosome alignment (By similarity). Second, functions during cytokinesis in part by regulating assembly and organization of central spindle and midbody MTs (By similarity). Plays a role in retina morphogenesis and/or homeostasis (PubMed:21680557). {ECO:0000250|UniProtKB:A2RUB6, ECO:0000269|PubMed:21680557, ECO:0000269|PubMed:40729374}.
uniprot
proteins
mass_dalton
107372
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19777273
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21680557
uniprot
proteins
pubmed
40729374
uniprot
proteins
sequence_length
935
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:A2RUB6}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite {ECO:0000250|UniProtKB:A2RUB6}. Cell projection, cilium {ECO:0000250|UniProtKB:A2RUB6}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:A2RUB6}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:40729374}. Photoreceptor inner segment {ECO:0000269|PubMed:19777273}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:19777273}. Note=Restricted to the centrosomes and the spindle microtubules during mitosis (By similarity). Enriched in the inner segment of the photoreceptor (PubMed:19777273). {ECO:0000250|UniProtKB:A2RUB6, ECO:0000269|PubMed:19777273}.
uniprot
proteins