PYCR3
entrez
65263
canonical
uniprot
Q53H96
canonical
ensembl
ENSG00000104524
resolver
ensembl
ENSG00000276657
resolver
ensp
ENSP00000404493
resolver
ensp
ENSP00000480945
resolver
ensp
ENSP00000484458
resolver
enst
ENST00000616663
resolver
genesymbol
PYCR3
resolver
genesymbol_syn
PYCRL
resolver
hgnc
HGNC:25846
resolver
uniprot
A0A0A0MQS1
resolver
uniprot
B3KMB5
resolver
uniprot
B4DGI7
resolver
uniprot
B4DVT6
resolver
uniprot
H0Y6C3
resolver
uniprot
Q8N3N9
resolver
uniprot
Q96HX4
resolver
uniprot
Q9H896
resolver
uniprot_entry
A0A0A0MQS1_HUMAN
resolver
uniprot_entry
B4DGI7_HUMAN
resolver
uniprot_entry
P5CR3_HUMAN
resolver
uniprot_sec
B3KMB5
resolver
uniprot_sec
B4DVT6
resolver
uniprot_sec
H0Y6C3
resolver
uniprot_sec
Q8N3N9
resolver
uniprot_sec
Q96HX4
resolver
uniprot_sec
Q9H896
resolver
activity_regulation
ACTIVITY REGULATION: Competitive inhibition by proline analog N-formyl-L-proline (PubMed:36414121). Weakly inhibited by proline (PubMed:23024808, PubMed:36414121). {ECO:0000269|PubMed:23024808, ECO:0000269|PubMed:36414121}.
uniprot
proteins
amino_acid_sequence
MAAAEPSPRRVGFVGAGRMAGAIAQGLIRAGKVEAQHILASAPTDRNLCHFQALGCRTTHSNQEVLQSCLLVIFATKPHVLPAVLAEVAPVVTTEHILVSVAAGVSLSTLEELLPPNTRVLRVLPNLPCVVQEGAIVMARGRHVGSSETKLLQHLLEACGRCEEVPEAYVDIHTGLSGSGVAFVCAFSEALAEGAVKMGMPSSLAHRIAAQTLLGTAKMLLHEGQHPAQLRSDVCTPGGTTIYGLHALEQGGLRAATMSAVEAATCRAKELSRK
uniprot
proteins
ec_number
1.5.1.2
uniprot
proteins
function
FUNCTION: Oxidoreductase that catalyzes the last step in proline biosynthesis, which corresponds to the reduction of pyrroline-5-carboxylate (P5C) to L-proline using NAD(P)H (PubMed:23024808, PubMed:36414121). Proline is synthesized from either glutamate or ornithine; both are converted to P5C, and then to proline via pyrroline-5-carboxylate reductases (PYCRs) (PubMed:23024808). PYCR3 is exclusively linked to the biosynthesis of proline from ornithine (PubMed:23024808). {ECO:0000269|PubMed:23024808, ECO:0000269|PubMed:36414121}.
uniprot
proteins
mass_dalton
28663
uniprot
proteins
pathway_participation
PATHWAY: Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1. {ECO:0000269|PubMed:23024808}.
uniprot
proteins
protein_family
Pyrroline-5-carboxylate reductase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23024808
uniprot
proteins
pubmed
36414121
uniprot
proteins
sequence_length
274
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:23024808}.
uniprot
proteins