RGMA
entrez
56963
canonical
uniprot
Q96B86
canonical
ensembl
ENSG00000182175
resolver
ensp
ENSP00000330005
resolver
ensp
ENSP00000404442
resolver
ensp
ENSP00000440025
resolver
ensp
ENSP00000442498
resolver
ensp
ENSP00000452126
resolver
enst
ENST00000557301
resolver
genesymbol
RGMA
resolver
genesymbol_syn
RGM
resolver
hgnc
HGNC:30308
resolver
uniprot
A0A0A0MTQ4
resolver
uniprot
B2RTW1
resolver
uniprot
B7Z5S8
resolver
uniprot
F5GXQ7
resolver
uniprot
F5GZU6
resolver
uniprot
G3V518
resolver
uniprot
Q0JV97
resolver
uniprot
Q8NC80
resolver
uniprot
Q9H0E6
resolver
uniprot
Q9NPM3
resolver
uniprot_entry
A0A0A0MTQ4_HUMAN
resolver
uniprot_entry
RGMA_HUMAN
resolver
uniprot_sec
B2RTW1
resolver
uniprot_sec
B7Z5S8
resolver
uniprot_sec
F5GXQ7
resolver
uniprot_sec
F5GZU6
resolver
uniprot_sec
G3V518
resolver
uniprot_sec
Q0JV97
resolver
uniprot_sec
Q8NC80
resolver
uniprot_sec
Q9H0E6
resolver
uniprot_sec
Q9NPM3
resolver
amino_acid_sequence
MQPPRERLVVTGRAGWMGMGRGAGRSALGFWPTLAFLLCSFPAATSPCKILKCNSEFWSATSGSHAPASDDTPEFCAALRSYALCTRRTARTCRGDLAYHSAVHGIEDLMSQHNCSKDGPTSQPRLRTLPPAGDSQERSDSPEICHYEKSFHKHSATPNYTHCGLFGDPHLRTFTDRFQTCKVQGAWPLIDNNYLNVQVTNTPVLPGSAATATSKLTIIFKNFQECVDQKVYQAEMDELPAAFVDGSKNGGDKHGANSLKITEKVSGQHVEIQAKYIGTTIVVRQVGRYLTFAVRMPEEVVNAVEDWDSQGLYLCLRGCPLNQQIDFQAFHTNAEGTGARRLAAASPAPTAPETFPYETAVAKCKEKLPVEDLYYQACVFDLLTTGDVNFTLAAYYALEDVKMLHSNKDKLHLYERTRDLPGRAAAGLPLAPRPLLGALVPLLALLPVFC
uniprot
proteins
function
FUNCTION: Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8. {ECO:0000269|PubMed:19273616, ECO:0000269|PubMed:19458235}.
uniprot
proteins
mass_dalton
49361
uniprot
proteins
post_translational_modification
PTM: Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds. {ECO:0000250}.
uniprot
proteins
protein_family
Repulsive guidance molecule (RGM) family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
19273616
uniprot
proteins
pubmed
19458235
uniprot
proteins
sequence_length
450
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.
uniprot
proteins