Il13ra2
entrez
16165
canonical
uniprot
O88786
canonical
ensembl
ENSMUSG00000031289
resolver
ensp
ENSMUSP00000033646
resolver
ensp
ENSMUSP00000108446
resolver
genesymbol
Il13ra2
resolver
uniprot
A3F812
resolver
uniprot
Q3V2V5
resolver
uniprot_entry
I13R2_MOUSE
resolver
uniprot_sec
A3F812
resolver
uniprot_sec
Q3V2V5
resolver
amino_acid_sequence
MAFVHIRCLCFILLCTITGYSLEIKVNPPQDFEILDPGLLGYLYLQWKPPVVIEKFKGCTLEYELKYRNVDSDSWKTIITRNLIYKDGFDLNKGIEGKIRTHLSEHCTNGSEVQSPWIEASYGISDEGSLETKIQDMKCIYYNWQYLVCSWKPGKTVYSDTNYTMFFWYEGLDHALQCADYLQHDEKNVGCKLSNLDSSDYKDFFICVNGSSKLEPIRSSYTVFQLQNIVKPLPPEFLHISVENSIDIRMKWSTPGGPIPPRCYTYEIVIREDDISWESATDKNDMKLKRRANESEDLCFFVRCKVNIYCADDGIWSEWSEEECWEGYTGPDSKIIFIVPVCLFFIFLLLLLCLIVEKEEPEPTLSLHVDLNKEVCAYEDTLC
uniprot
proteins
function
FUNCTION: Cell surface receptor that plays a role in the regulation of IL-13-mediated responses (PubMed:12642602). Functions as a decoy receptor that inhibits IL-13- and IL-4-mediated signal transduction via the JAK-STAT pathway and thereby modulates immune responses and inflammation. Serves as a functional signaling receptor for IL-13 in an alternative pathway involving AP-1 ultimately leading to the production of TGFB1. {ECO:0000250|UniProtKB:Q14627, ECO:0000269|PubMed:12642602}.
uniprot
proteins
mass_dalton
44483
uniprot
proteins
post_translational_modification
PTM: Cleaved by MMP8 leading to a soluble form that is also able to interact with IL13. {ECO:0000250|UniProtKB:Q14627}.
uniprot
proteins
protein_family
Type 5 subfamily
uniprot
proteins
protein_family
Type I cytokine receptor family
uniprot
proteins
pubmed
12642602
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17114462
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
9725226
uniprot
proteins
sequence_length
383
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000250|UniProtKB:Q14627}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q14627}.; SUBCELLULAR LOCATION: [Isoform 2]: Secreted.
uniprot
proteins
transmembrane_region
TRANSMEM 335..355; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins