Trpm4
entrez
171143
canonical
uniprot
Q9ESQ5
canonical
ensembl
ENSRNOG00000020714
resolver
ensp
ENSRNOP00000041387
resolver
genesymbol
Trpm4
resolver
genesymbol_syn
Ltrpc4
resolver
uniprot_entry
TRPM4_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Gating is voltage-dependent and repressed by decavanadate. Calmodulin-binding confers the Ca(2+) sensitivity. ATP is able to restore Ca(2+) sensitivity after desensitization (PubMed:16966582). Phosphatidylinositol 4,5-bisphosphate (PIP2)-binding strongly enhances activity, by increasing the channel's Ca(2+) sensitivity and shifting its voltage dependence of activation towards negative potentials. Activity is also enhanced by 3,5-bis(trifluoromethyl)pyrazole derivative (BTP2) (By similarity). Exhibits pronounced temperature sensitivity, with activities strongly intensifying near physiological temperatures. TRPM4 can adopt distinct conformations at different temperatures, markedly influencing where and how ligands interact with them. {ECO:0000250|UniProtKB:Q8TD43, ECO:0000269|PubMed:16966582}.
uniprot
proteins
amino_acid_sequence
MVGQEKEQSWIPKIFRKKVCTTFIVDLHDDAGGTLCQCGQPRDAHPSVAVEDAFGAAVVTEWNSDEHTTEKPTDAYGDLDFTYSGRKSSNFLRLSDRTDPATVYSLVTRSWGFRAPNLVVSVLGGSEGPVLQTWLQDLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVAVRDHQTASTGGSKVVAMGVAPWGVVRNRDMLINPKGSFPARYRWRGDPEDGVEFPLDYNYSAFFLVDDGTYGRMGGENRFRLRFESYVAQQKTGVGGTGIDIPVLLLLIEGDEKMLKRIEDATQAQLPCLLVAGSGGAADCLVETLEDTLAPGSGGLRRGEARDRIRRYFPKGDPEVLQAQVERIMTRKELLTVYSSEDGSEEFETIVLRALVKACGSSEASAYLDELRLAVAWNRVDIAQSELFRGDIQWRSFHLEASLMDALLNDRPEFVRLLISHGLSLGHFLTPVRLAQLYSAVSPNSLIRNLLDQASHASSSKSPPANGAAELRPPNVGQVLRTLLGETCAPRYPARNTRHSLLGQDHRENDSLLMDWANMQQDASFEQAPWSDLLIWALLLNRAQMAIYFWEKGSNSVASALGACLLLRVMARLEWEAEEAARRKDLAAKFESMSVDLFGECYHNSEYRAARLLLRRCPLWGEATCLQLAMQADARAFFAQDGVQSLLTQKWWGEMDSTNPIWALLLTFFCPPLIYTNLILFRKSEEEPTQKDLDFDMDSSMNGAGPLGPAEPSAKVALERRRRRRPGHTLCCGGCSKRWSYFWGAPVTAFLGNVVSYLLFLLLFAHVLLVDFQPTKPGVFELLLYFWAFTLLCEELRQGLGGGWGTLANGGPGPGKAPLRHRLHLYLLDTWNQCDLLALTCFLLGVGCRLTPGLFDLGRTVLCLDFMIFTLRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLCVWLVAYGVATEGILRPQDRSLPSILRRVFYRPYLQIFGQIPQEEMDVALMNPSNCSAERGSWAHPEGPVAGSCVSQYANWLVVLLLIVFLLVANILLLNLLIAMFSYTFNKVHGNSDLYWKAQRYSLIREFHSRPALAPPLIIISHLRLLFKWLRRCHRTNLPASPVFEHFRVCLSKEAERTLLTWESVHKENFLLAQARDKRDSDSERLKRTSQKVDTALKQLGQIREYDRRLRGLEREVQHCSRVLTWMAEALSHSALLPPGGPPPPSPTGSKD
uniprot
proteins
function
FUNCTION: Calcium-activated selective cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane (PubMed:16966582, PubMed:19945433). It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Plays a role in keratinocyte differentiation (By similarity). {ECO:0000250|UniProtKB:Q8TD43, ECO:0000269|PubMed:16966582, ECO:0000269|PubMed:19945433}.; FUNCTION: [Isoform 2]: Lacks channel activity. {ECO:0000269|PubMed:19945433}.
uniprot
proteins
mass_dalton
135341
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by PKC leads to increase the sensitivity to Ca(2+). {ECO:0000250|UniProtKB:Q8TD43}.; PTM: Sumoylated. Desumoylated by SENP1. {ECO:0000250|UniProtKB:Q8TD43}.
uniprot
proteins
protein_family
LTrpC subfamily
uniprot
proteins
protein_family
TRPM4 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
pubmed
15030426
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
16966582
uniprot
proteins
pubmed
19945433
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
1208
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane {ECO:0000269|PubMed:19945433}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TD43}. Endoplasmic reticulum {ECO:0000269|PubMed:19945433}. Golgi apparatus {ECO:0000269|PubMed:19945433}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:19945433}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q8TD43}. Endoplasmic reticulum {ECO:0000269|PubMed:19945433}. Golgi apparatus {ECO:0000269|PubMed:19945433}. Note=Mainly integrated into the ER/Golgi complex and is rarely found in the plasma membrane. {ECO:0000269|PubMed:19945433}.
uniprot
proteins
transmembrane_region
TRANSMEM 777..797; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q7TN37"; TRANSMEM 809..829; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q7TN37"; TRANSMEM 858..878; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q7TN37"; TRANSMEM 881..904; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q7TN37"; TRANSMEM 925..945; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q7TN37"; TRANSMEM 1014..1034; /note="Helical"; /evidence="ECO:0000250|UniProtKB:Q7TN37
uniprot
proteins