MVP
entrez
9961
canonical
uniprot
Q14764
canonical
ensembl
ENSG00000013364
resolver
ensp
ENSP00000349977
resolver
ensp
ENSP00000378760
resolver
ensp
ENSP00000522188
resolver
ensp
ENSP00000522189
resolver
ensp
ENSP00000522190
resolver
ensp
ENSP00000522191
resolver
ensp
ENSP00000522192
resolver
ensp
ENSP00000522193
resolver
ensp
ENSP00000619088
resolver
ensp
ENSP00000619089
resolver
ensp
ENSP00000700418
resolver
enst
ENST00000357402
resolver
enst
ENST00000395353
resolver
enst
ENST00000852129
resolver
enst
ENST00000852130
resolver
enst
ENST00000852131
resolver
enst
ENST00000852132
resolver
enst
ENST00000852133
resolver
enst
ENST00000852134
resolver
enst
ENST00000949029
resolver
enst
ENST00000949030
resolver
genesymbol
MVP
resolver
genesymbol_syn
LRP
resolver
hgnc
HGNC:7531
resolver
uniprot
Q96BG4
resolver
uniprot
Q9BPW6
resolver
uniprot
Q9BQT1
resolver
uniprot
Q9UBD1
resolver
uniprot
X5D2M8
resolver
uniprot
X5D7K9
resolver
uniprot
X5DNU0
resolver
uniprot_entry
MVP_HUMAN
resolver
uniprot_entry
X5D2M8_HUMAN
resolver
uniprot_entry
X5D7K9_HUMAN
resolver
uniprot_entry
X5DNU0_HUMAN
resolver
uniprot_sec
Q96BG4
resolver
uniprot_sec
Q9BPW6
resolver
uniprot_sec
Q9BQT1
resolver
uniprot_sec
Q9UBD1
resolver
amino_acid_sequence
MATEEFIIRIPPYHYIHVLDQNSNVSRVEVGPKTYIRQDNERVLFAPMRMVTVPPRHYCTVANPVSRDAQGLVLFDVTGQVRLRHADLEIRLAQDPFPLYPGEVLEKDITPLQVVLPNTALHLKALLDFEDKDGDKVVAGDEWLFEGPGTYIPRKEVEVVEIIQATIIRQNQALRLRARKECWDRDGKERVTGEEWLVTTVGAYLPAVFEEVLDLVDAVILTEKTALHLRARRNFRDFRGVSRRTGEEWLVTVQDTEAHVPDVHEEVLGVVPITTLGPHNYCVILDPVGPDGKNQLGQKRVVKGEKSFFLQPGEQLEQGIQDVYVLSEQQGLLLRALQPLEEGEDEEKVSHQAGDHWLIRGPLEYVPSAKVEVVEERQAIPLDENEGIYVQDVKTGKVRAVIGSTYMLTQDEVLWEKELPPGVEELLNKGQDPLADRGEKDTAKSLQPLAPRNKTRVVSYRVPHNAAVQVYDYREKRARVVFGPELVSLGPEEQFTVLSLSAGRPKRPHARRALCLLLGPDFFTDVITIETADHARLQLQLAYNWHFEVNDRKDPQETAKLFSVPDFVGDACKAIASRVRGAVASVTFDDFHKNSARIIRTAVFGFETSEAKGPDGMALPRPRDQAVFPQNGLVVSSVDVQSVEPVDQRTRDALQRSVQLAIEITTNSQEAAAKHEAQRLEQEARGRLERQKILDQSEAEKARKELLELEALSMAVESTGTAKAEAESRAEAARIEGEGSVLQAKLKAQALAIETEAELQRVQKVRELELVYARAQLELEVSKAQQLAEVEVKKFKQMTEAIGPSTIRDLAVAGPEMQVKLLQSLGLKSTLITDGSTPINLFNTAFGLLGMGPEGQPLGRRVASGPSPGEGISPQSAQAPQAPGDNHVVPVLR
uniprot
proteins
function
FUNCTION: Structural component of the vault particle, which is a massive ribonucleoprotein complex that may play a role in cargo transport and signal transduction (PubMed:40691181). Oligomerizes to form a cage-like vault complex, which can house several minor vault components including PARP4 (PubMed:40691181). Vaults may play a role in nucleo-cytoplasmic transport (PubMed:15133037). Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK (PubMed:16418217). Down-regulates SRC activity and signaling through MAP kinases (PubMed:16441665). {ECO:0000269|PubMed:15133037, ECO:0000269|PubMed:16418217, ECO:0000269|PubMed:16441665, ECO:0000269|PubMed:40691181}.
uniprot
proteins
mass_dalton
99327
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Tyr residues after EGF stimulation (PubMed:15133037). {ECO:0000269|PubMed:15133037}.; PTM: Dephosphorylated by PTPN11 (PubMed:15133037). {ECO:0000269|PubMed:15133037}.
uniprot
proteins
protein_family
Major vault protein family
uniprot
proteins
pubmed
10551828
uniprot
proteins
pubmed
11071864
uniprot
proteins
pubmed
11297743
uniprot
proteins
pubmed
12177006
uniprot
proteins
pubmed
15133037
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16373071
uniprot
proteins
pubmed
16418217
uniprot
proteins
pubmed
16441665
uniprot
proteins
pubmed
16815308
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18809583
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28895081
uniprot
proteins
pubmed
40691181
uniprot
proteins
pubmed
7585126
uniprot
proteins
sequence_length
893
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15133037, ECO:0000269|PubMed:16441665}. Nucleus, nuclear pore complex {ECO:0000269|PubMed:16441665}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:16441665}. Note=5% found in the nuclear pore complex (PubMed:15133037). Translocates from the nucleus to the cytoplasm upon EGF treatment (PubMed:16441665). {ECO:0000269|PubMed:15133037, ECO:0000269|PubMed:16441665}.
uniprot
proteins