Golga2
entrez
99412
canonical
uniprot
Q921M4
canonical
ensembl
ENSMUSG00000002546
resolver
ensp
ENSMUSP00000080374
resolver
ensp
ENSMUSP00000097768
resolver
ensp
ENSMUSP00000159316
resolver
ensp
ENSMUSP00000159347
resolver
ensp
ENSMUSP00000258795
resolver
ensp
ENSMUSP00000258799
resolver
ensp
ENSMUSP00000258806
resolver
ensp
ENSMUSP00000258807
resolver
enst
ENSMUST00000081670
resolver
enst
ENSMUST00000100194
resolver
enst
ENSMUST00000239447
resolver
enst
ENSMUST00000239474
resolver
genesymbol
Golga2
resolver
genesymbol_syn
mKIAA4150
resolver
uniprot
A0A6I8MWY5
resolver
uniprot
A0A6I8MX07
resolver
uniprot
A2AN43
resolver
uniprot
A2AN47
resolver
uniprot
E9PUQ5
resolver
uniprot
Q5DTL1
resolver
uniprot
Z4YJU8
resolver
uniprot_entry
A0A6I8MWY5_MOUSE
resolver
uniprot_entry
A0A6I8MX07_MOUSE
resolver
uniprot_entry
E9PUQ5_MOUSE
resolver
uniprot_entry
GOGA2_MOUSE
resolver
uniprot_entry
Q5DTL1_MOUSE
resolver
uniprot_entry
Z4YJU8_MOUSE
resolver
uniprot_sec
A2AN43
resolver
uniprot_sec
A2AN47
resolver
amino_acid_sequence
MWPPRFPPPRPGMSEETRQSKLAAAKKKLREYQQKNSPGVPAGAKKKKKIKNGHSPERPTASDCQSPENVPTDHIAPAPPTAATDTMFLGVTPSPDADLTQSHDAGNCSNLMEETKTFSSTESLRQLSQQLNGLVSESTSYINGEGLTSSNMKELENRYQELAVALDSSYVTNKQLSSTIEELKQQNQDTLDQLEKEKKDYQQKLAKEQGSLREQLQVHIQTIGILVSEKAELQTALAHTQQAARQKAGESEDLASRLQSSRQRVGELERTLSTVSTQQKQADRYNKDLTKERDALKLELYKNSKSNEDLRQQNSELEEKLRVLVAEKAAAQLGVEELQKKLEMSELLLQQFSSQSSAAGGNEQLQHAMEERAQLETHVSQLMESLKQLQVERDQYAENLKGESAMWQQRVQQMAEQVHTLKEEKEHRERQVQELETSLAALRSQMEEPPPPEPPAGPSEAEEQLQGEVEQLHKELERLTGQLRAQVQDNESLSHLNREQEGRLLELEREAQRWSEQAEERKQILESMQSDRTTISRALSQNRELKEQLAELQNGFVRLTNENMEITSALQSEQHVKKELARKLGELQERLGELKETVELKSQEAQGLQEQRDQCLSHLQQYAAAYQQHLAAYEQLTSEKEAIHKQLLLQTQLMDQLQHEEVQGKMAAELARQELQEAQERLKATSQENQQLQAQLSLLVLPGEGDVDQEEEDEEVPQSSLAIPEDLDSREAMVAFFNAAIARAEEEQARLRVQLKEQKARCRSLSHLAAPVQSKLEKEAVVPRNVDDSASEESNQALHVAMEKLQSRFLEVMQEKVELKERVEELEHCCIQLSGETDTIGEYIALYQNQRAVLKARHLEKEEYISRLAQDKEEMKVKLLELQELVLRLVNERNEWQGKFLAVSQNPGDVLTPVPTGSQEFGAADQQDDLREVSLADDIEPAQGEAGVPAPHENPTAQQIMQLLREIQNPRERPGLGSNPCIPFFYRADENDEVKIMVV
uniprot
proteins
function
FUNCTION: Peripheral membrane component of the cis-Golgi stack that acts as a membrane skeleton that maintains the structure of the Golgi apparatus, and as a vesicle thether that facilitates vesicle fusion to the Golgi membrane (PubMed:28028212). Required for normal protein transport from the endoplasmic reticulum to the Golgi apparatus and the cell membrane (PubMed:28028212). Together with p115/USO1 and STX5, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus. Plays a central role in mitotic Golgi disassembly: phosphorylation at Ser-37 by CDK1 at the onset of mitosis inhibits the interaction with p115/USO1, preventing tethering of COPI vesicles and thereby inhibiting transport through the Golgi apparatus during mitosis. Also plays a key role in spindle pole assembly and centrosome organization (By similarity). Promotes the mitotic spindle pole assembly by activating the spindle assembly factor TPX2 to nucleate microtubules around the Golgi and capture them to couple mitotic membranes to the spindle: upon phosphorylation at the onset of mitosis, GOLGA2 interacts with importin-alpha via the nuclear localization signal region, leading to recruit importin-alpha to the Golgi membranes and liberate the spindle assembly factor TPX2 from importin-alpha. TPX2 then activates AURKA kinase and stimulates local microtubule nucleation. Upon filament assembly, nascent microtubules are further captured by GOLGA2, thus linking Golgi membranes to the spindle (By similarity). Regulates the meiotic spindle pole assembly, probably via the same mechanism (PubMed:21552007). Also regulates the centrosome organization (By similarity). Also required for the Golgi ribbon formation and glycosylation of membrane and secretory proteins (By similarity). {ECO:0000250|UniProtKB:Q08379, ECO:0000250|UniProtKB:Q62839, ECO:0000269|PubMed:21552007, ECO:0000269|PubMed:28028212}.
uniprot
proteins
mass_dalton
113278
uniprot
proteins
post_translational_modification
PTM: Phosphorylated at Ser-37 by CDK1 at the onset of mitosis, inhibiting the interaction with p115/USO1 and triggering Golgi disassembly. A report however suggests that Golgi disassembly is independent of phosphorylation at Ser-37. Phosphorylated at Ser-37 in prophase as the Golgi complex starts to break down, and remains phosphorylated during further breakdown and partitioning of the Golgi fragments in metaphase and anaphase. In telophase, GM130 is dephosphorylated by PP2A as the Golgi fragments start to reassemble. {ECO:0000250|UniProtKB:Q62839}.; PTM: Cleaved by caspases at the onset of apoptosis. {ECO:0000250|UniProtKB:Q08379}.; PTM: Methylation by PRMT5 is required for Golgi ribbon formation. {ECO:0000250|UniProtKB:Q08379}.
uniprot
proteins
protein_family
GOLGA2 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21552007
uniprot
proteins
pubmed
26165940
uniprot
proteins
pubmed
26742501
uniprot
proteins
pubmed
28028212
uniprot
proteins
pubmed
28617811
uniprot
proteins
sequence_length
999
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, cis-Golgi network membrane {ECO:0000250|UniProtKB:Q08379}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q08379}; Cytoplasmic side {ECO:0000250|UniProtKB:Q08379}. Endoplasmic reticulum-Golgi intermediate compartment membrane {ECO:0000250|UniProtKB:Q08379}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q08379}; Cytoplasmic side {ECO:0000250|UniProtKB:Q08379}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000250|UniProtKB:Q08379}. Note=Associates with the mitotic spindle during mitosis. {ECO:0000250|UniProtKB:Q08379, ECO:0000250|UniProtKB:Q62839}.
uniprot
proteins