TMEM258
entrez
746
canonical
uniprot
P61165
canonical
ensembl
ENSG00000134825
resolver
ensp
ENSP00000257262
resolver
ensp
ENSP00000443216
resolver
ensp
ENSP00000527068
resolver
ensp
ENSP00000617621
resolver
enst
ENST00000257262
resolver
enst
ENST00000537328
resolver
enst
ENST00000857009
resolver
enst
ENST00000947562
resolver
genesymbol
TMEM258
resolver
genesymbol_syn
C11orf10
resolver
hgnc
HGNC:1164
resolver
uniprot
A8K6L8
resolver
uniprot
Q9D953
resolver
uniprot
Q9Y2Q7
resolver
uniprot_entry
TM258_HUMAN
resolver
uniprot_sec
A8K6L8
resolver
uniprot_sec
Q9D953
resolver
uniprot_sec
Q9Y2Q7
resolver
amino_acid_sequence
MELEAMSRYTSPVNPAVFPHLTVVLLAIGMFFTAWFFVYEVTSTKYTRDIYKELLISLVASLFMGFGVLFLLLWVGIYV
uniprot
proteins
function
FUNCTION: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation (PubMed:31831667). N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (PubMed:26472760, PubMed:27974209). Involved in ER homeostasis in the colonic epithelium (By similarity). {ECO:0000250|UniProtKB:P61166, ECO:0000269|PubMed:26472760, ECO:0000269|PubMed:27974209, ECO:0000269|PubMed:31831667}.
uniprot
proteins
mass_dalton
9079
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:31831667}.
uniprot
proteins
protein_family
OST5 family
uniprot
proteins
pubmed
11042152
uniprot
proteins
pubmed
12427278
uniprot
proteins
pubmed
12665801
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
26472760
uniprot
proteins
pubmed
27974209
uniprot
proteins
pubmed
28716842
uniprot
proteins
pubmed
31831667
uniprot
proteins
pubmed
36697828
uniprot
proteins
pubmed
38670073
uniprot
proteins
sequence_length
79
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:28716842}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum {ECO:0000269|PubMed:26472760, ECO:0000269|PubMed:27974209}. Cytoplasm {ECO:0000269|PubMed:12427278, ECO:0000269|PubMed:28716842}.
uniprot
proteins
transmembrane_region
TRANSMEM 17..37; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 55..75; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins