Clpx
entrez
300786
canonical
uniprot
Q5U2U0
canonical
ensembl
ENSRNOG00000030225
resolver
ensp
ENSRNOP00000088175
resolver
ensp
ENSRNOP00000088647
resolver
enst
ENSRNOT00000097161
resolver
genesymbol
Clpx
resolver
uniprot_entry
CLPX_RAT
resolver
amino_acid_sequence
MSSCGACTCGAAAARLLTTSLTSAQRGISCGRIHVPVLGRLGTLDTQILRRAPLRTFSETPAYFASKDGTNKDGSGDGNKKSVTEGSSKKSGSGNSGKGGNQLRCPKCGDLCTHVETFVSSTRFVKCEKCHHFFVVLSEADSKKSIIKEPESAAEAVKLAFQQKPPPPPKKIYNYLDKYVVGQSFAKKVLSVAVYNHYKRIYNNIPANLRQQAEVEKQTSLTPRELEIRRREDEYRFTKLLQIAGISPHGNALGASMQQQGSQQMPQEKRGGEVLDSPHDDIKLEKSNILLLGPTGSGKTLLAQTLAKCLDVPFAICDCTTLTQAGYVGEDIESVIAKLLQDANYNVEKAQQGIVFLDEVDKIGSVPGIHQLRDVGGEGVQQGLLKLLEGTIVNVPEKNSRKLRGETVQVDTTNILFVASGAFNGLDRIISRRKNEKYLGFGTPSNLGKGRRAAAAADLANRSGESNTHQDIEEKDRLLRHVEARDLIEFGMIPEFVGRLPVVVPLHSLDEKTLVQILTEPRNAVIPQYQALFSMDKCELNVTEDALKAIARLALERKTGARGLRSIMEKLLLEPMFEVPNSDIVCVEVDKEVVEGKKEPGYIRAPSKESSEEDYDSGVEEDGWPRQADAANS
uniprot
proteins
ec_number
3.6.4.10
uniprot
proteins
function
FUNCTION: ATP-dependent chaperone that functions as an unfoldase. As part of the ClpXP protease complex, it recognizes specific protein substrates, unfolds them using energy derived from ATP hydrolysis, and then translocates them to the proteolytic subunit (CLPP) of the ClpXP complex for degradation. Thanks to its chaperone activity, it also functions in the incorporation of the pyridoxal phosphate cofactor into 5-aminolevulinate synthase, thereby activating 5-aminolevulinate (ALA) synthesis, the first step in heme biosynthesis. This chaperone is also involved in the control of mtDNA nucleoid distribution, by regulating mitochondrial transcription factor A (TFAM) activity. {ECO:0000250|UniProtKB:O76031}.
uniprot
proteins
mass_dalton
69208
uniprot
proteins
protein_family
ClpX chaperone family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
633
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:O76031}. Mitochondrion matrix, mitochondrion nucleoid {ECO:0000250|UniProtKB:O76031}.
uniprot
proteins