HIP1R
entrez
9026
canonical
uniprot
O75146
canonical
ensembl
ENSG00000130787
resolver
ensp
ENSP00000253083
resolver
ensp
ENSP00000716910
resolver
genesymbol
HIP1R
resolver
genesymbol_syn
HIP12
resolver
genesymbol_syn
KIAA0655
resolver
hgnc
HGNC:18415
resolver
uniprot
A6NHQ6
resolver
uniprot
B3KQW8
resolver
uniprot
B4DPL0
resolver
uniprot
Q6NXG8
resolver
uniprot
Q9UED9
resolver
uniprot_entry
B3KQW8_HUMAN
resolver
uniprot_entry
B4DPL0_HUMAN
resolver
uniprot_entry
HIP1R_HUMAN
resolver
uniprot_sec
A6NHQ6
resolver
uniprot_sec
Q6NXG8
resolver
uniprot_sec
Q9UED9
resolver
amino_acid_sequence
MNSIKNVPARVLSRRPGHSLEAEREQFDKTQAISISKAINTQEAPVKEKHARRIILGTHHEKGAFTFWSYAIGLPLPSSSILSWKFCHVLHKVLRDGHPNVLHDCQRYRSNIREIGDLWGHLHDRYGQLVNVYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEMFDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLLFKLHSCLPADTLQGHRDRFHEQFHSLRNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHIKPVVVIPEEAPEDEEPENLIEISTGPPAGEPVVVADLFDQTFGPPNGSVKDDRDLQIESLKREVEMLRSELEKIKLEAQRYIAQLKSQVNALEGELEEQRKQKQKALVDNEQLRHELAQLRAAQLEGERSQGLREEAERKASATEARYNKLKEKHSELVHVHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQVEQVKRESELKLEEKSDQLEKLKRELEAKAGELARAQEALSHTEQSKSELSSRLDTLSAEKDALSGAVRQREADLLAAQSLVRETEAALSREQQRSSQEQGELQGRLAERESQEQGLRQRLLDEQFAVLRGAAAEAAGILQDAVSKLDDPLHLRCTSSPDYLVSRAQEALDAVSTLEEGHAQYLTSLADASALVAALTRFSHLAADTIINGGATSHLAPTDPADRLIDTCRECGARALELMGQLQDQQALRHMQASLVRTPLQGILQLGQELKPKSLDVRQEELGAVVDKEMAATSAAIEDAVRRIEDMMNQARHASSGVKLEVNERILNSCTDLMKAIRLLVTTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVEAADKVVLHTGKYEELIVCSHEIAASTAQLVAASKVKANKHSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERMRLGELRKQHYVLAGASGSPGEEVAIRPSTAPRSVTTKKPPLAQKPSVAPRQDHQLDKKDGIYPAQLVNY
uniprot
proteins
function
FUNCTION: Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. {ECO:0000269|PubMed:11889126, ECO:0000269|PubMed:14732715}.
uniprot
proteins
mass_dalton
119388
uniprot
proteins
mutagenesis
MUTAGEN 867; /note="R->D: Reduced acting binding."; /evidence="ECO:0000269|PubMed:16415883"; MUTAGEN 871; /note="G->D: Reduced acting binding."; /evidence="ECO:0000269|PubMed:16415883"; MUTAGEN 875; /note="A->D: Reduced acting binding."; /evidence="ECO:0000269|PubMed:16415883"; MUTAGEN 922..924; /note="KVK->DDD: Strongly reduced actin binding."; /evidence="ECO:0000269|PubMed:16415883
uniprot
proteins
protein_family
SLA2 family
uniprot
proteins
pubmed
11063258
uniprot
proteins
pubmed
11889126
uniprot
proteins
pubmed
14732715
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15533940
uniprot
proteins
pubmed
16415883
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
19255499
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
9734811
uniprot
proteins
pubmed
9852681
uniprot
proteins
sequence_length
1068
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note=Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region.
uniprot
proteins