TTLL4
entrez
9654
canonical
uniprot
Q14679
canonical
ensembl
ENSG00000135912
resolver
ensp
ENSP00000375951
resolver
ensp
ENSP00000393332
resolver
ensp
ENSP00000533418
resolver
ensp
ENSP00000533420
resolver
ensp
ENSP00000533422
resolver
ensp
ENSP00000587411
resolver
ensp
ENSP00000628231
resolver
ensp
ENSP00000649191
resolver
ensp
ENSP00000681661
resolver
ensp
ENSP00000735723
resolver
enst
ENST00000392102
resolver
enst
ENST00000863359
resolver
enst
ENST00000863363
resolver
enst
ENST00000917352
resolver
enst
ENST00000958172
resolver
genesymbol
TTLL4
resolver
genesymbol_syn
KIAA0173
resolver
hgnc
HGNC:28976
resolver
uniprot
A8K6V5
resolver
uniprot
Q8WW29
resolver
uniprot_entry
TTLL4_HUMAN
resolver
uniprot_sec
A8K6V5
resolver
uniprot_sec
Q8WW29
resolver
amino_acid_sequence
MASAGTQHYSIGLRQKNSFKQSGPSGTVPATPPEKPSEGRVWPQAHQQVKPIWKLEKKQVETLSAGLGPGLLGVPPQPAYFFCPSTLCSSGTTAVIAGHSSSCYLHSLPDLFNSTLLYRRSSYRQKPYQQLESFCLRSSPSEKSPFSLPQKSLPVSLTANKATSSMVFSMAQPMASSSTEPYLCLAAAGENPSGKSLASAISGKIPSPLSSSYKPMLNNNSFMWPNSTPVPLLQTTQGLKPVSPPKIQPVSWHHSGGTGDCAPQPVDHKVPKSIGTVPADASAHIALSTASSHDTSTTSVASSWYNRNNLAMRAEPLSCALDDSSDSQDPTKEIRFTEAVRKLTARGFEKMPRQGCQLEQSSFLNPSFQWNVLNRSRRWKPPAVNQQFPQEDAGSVRRVLPGASDTLGLDNTVFCTKRISIHLLASHASGLNHNPACESVIDSSAFGEGKAPGPPFPQTLGIANVATRLSSIQLGQSEKERPEEARELDSSDRDISSATDLQPDQAETEDTEEELVDGLEDCCSRDENEEEEGDSECSSLSAVSPSESVAMISRSCMEILTKPLSNHEKVVRPALIYSLFPNVPPTIYFGTRDERVEKLPWEQRKLLRWKMSTVTPNIVKQTIGRSHFKISKRNDDWLGCWGHHMKSPSFRSIREHQKLNHFPGSFQIGRKDRLWRNLSRMQSRFGKKEFSFFPQSFILPQDAKLLRKAWESSSRQKWIVKPPASARGIGIQVIHKWSQLPKRRPLLVQRYLHKPYLISGSKFDLRIYVYVTSYDPLRIYLFSDGLVRFASCKYSPSMKSLGNKFMHLTNYSVNKKNAEYQANADEMACQGHKWALKALWNYLSQKGVNSDAIWEKIKDVVVKTIISSEPYVTSLLKMYVRRPYSCHELFGFDIMLDENLKPWVLEVNISPSLHSSSPLDISIKGQMIRDLLNLAGFVLPNAEDIISSPSSCSSSTTSLPTSPGDKCRMAPEHVTAQKMKKAYYLTQKIPDQDFYASVLDVLTPDDVRILVEMEDEFSRRGQFERIFPSHISSRYLRFFEQPRYFNILTTQWEQKYHGNKLKGVDLLRSWCYKGFHMGVVSDSAPVWSLPTSLLTISKDDVILNAFSKSETSKLGKQSSCEVSLLLSEDGTTPKSKKTQAGLSPYPQKPSSSKDSEDTSKEPSLSTQTLPVIKCSGQTSRLSASSTFQSISDSLLAVSP
uniprot
proteins
ec_number
6.3.2.-
uniprot
proteins
function
FUNCTION: Monoglutamylase which modifies both tubulin and non-tubulin proteins, adding a single glutamate on the gamma-carboxyl group of specific glutamate residues of target proteins. Involved in the side-chain initiation step of the polyglutamylation reaction but not in the elongation step. Preferentially modifies beta-tail tubulin over the alpha-tubulin. Monoglutamylates nucleosome assembly proteins NAP1L1 and NAP1L4. Monoglutamylates nucleotidyltransferase CGAS, leading to inhibition of CGAS catalytic activity, thereby preventing antiviral defense function. Involved in KLF4 glutamylation which impedes its ubiquitination, thereby leading to somatic cell reprogramming, pluripotency maintenance and embryogenesis. {ECO:0000250|UniProtKB:Q80UG8}.
uniprot
proteins
mass_dalton
133378
uniprot
proteins
mutagenesis
MUTAGEN 978..981; /note="KMKK->EMEE: Decreased binding to microtubules and polyglutamylase activity."; /evidence="ECO:0000269|PubMed:25959773
uniprot
proteins
protein_family
Tubulin--tyrosine ligase family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
25959773
uniprot
proteins
pubmed
8724849
uniprot
proteins
sequence_length
1199
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q80UG8}. Cell projection, cilium {ECO:0000250|UniProtKB:Q80UG8}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q80UG8}. Note=Located in cilia. In some cells, also found in basal bodies. {ECO:0000250|UniProtKB:Q80UG8}.
uniprot
proteins