ECSIT
entrez
51295
canonical
uniprot
Q9BQ95
canonical
ensembl
ENSG00000130159
resolver
ensp
ENSP00000252440
resolver
ensp
ENSP00000270517
resolver
ensp
ENSP00000412712
resolver
ensp
ENSP00000466559
resolver
genesymbol
ECSIT
resolver
hgnc
HGNC:29548
resolver
uniprot
E9PAN9
resolver
uniprot
K7EMM0
resolver
uniprot
Q96HQ7
resolver
uniprot
Q9NYI1
resolver
uniprot_entry
ECSIT_HUMAN
resolver
uniprot_sec
E9PAN9
resolver
uniprot_sec
K7EMM0
resolver
uniprot_sec
Q96HQ7
resolver
uniprot_sec
Q9NYI1
resolver
amino_acid_sequence
MSWVQATLLARGLCRAWGGTCGAALTGTSISQVPRRLPRGLHCSAAAHSSEQSLVPSPPEPRQRPTKALVPFEDLFGQAPGGERDKASFLQTVQKFAEHSVRKRGHIDFIYLALRKMREYGVERDLAVYNQLLNIFPKEVFRPRNIIQRIFVHYPRQQECGIAVLEQMENHGVMPNKETEFLLIQIFGRKSYPMLKLVRLKLWFPRFMNVNPFPVPRDLPQDPVELAMFGLRHMEPDLSARVTIYQVPLPKDSTGAADPPQPHIVGIQSPDQQAALARHNPARPVFVEGPFSLWLRNKCVYYHILRADLLPPEEREVEETPEEWNLYYPMQLDLEYVRSGWDNYEFDINEVEEGPVFAMCMAGAHDQATMAKWIQGLQETNPTLAQIPVVFRLAGSTRELQTSSAGLEEPPLPEDHQEEDDNLQRQQQGQS
uniprot
proteins
function
FUNCTION: Adapter protein that plays a role in different signaling pathways including TLRs and IL-1 pathways or innate antiviral induction signaling. Plays a role in the activation of NF-kappa-B by forming a signal complex with TRAF6 and TAK1/MAP3K7 to activate TAK1/MAP3K7 leading to activation of IKKs (PubMed:25355951, PubMed:31281713). Once ubiquitinated, interacts with the dissociated RELA and NFKB1 proteins and translocates to the nucleus where it induces NF-kappa-B-dependent gene expression (PubMed:25355951). Plays a role in innate antiviral immune response by bridging the pattern recognition receptors RIGI and MDA5/IFIT1 to the MAVS complex at the mitochondrion (PubMed:25228397). Promotes proteolytic activation of MAP3K1. Involved in the BMP signaling pathway. Required for normal embryonic development (By similarity). {ECO:0000250, ECO:0000269|PubMed:25228397, ECO:0000269|PubMed:25355951, ECO:0000269|PubMed:31281713}.; FUNCTION: As part of the MCIA complex, involved in the assembly of the mitochondrial complex I. {ECO:0000269|PubMed:32320651}.
uniprot
proteins
mass_dalton
49148
uniprot
proteins
mutagenesis
MUTAGEN 372; /note="K->A: Complete loss of interaction with RELA and NFKB1 together with loss of NF-kappa-B-dependent gene expression."; /evidence="ECO:0000269|PubMed:25355951
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated on Lys-372; leading to translocation in the nucleus together with RELA and NFKB1 and expression of NF-kappa-B-dependent genes. {ECO:0000269|PubMed:25355951}.
uniprot
proteins
protein_family
ECSIT family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17344420
uniprot
proteins
pubmed
20816094
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21525932
uniprot
proteins
pubmed
22588174
uniprot
proteins
pubmed
25228397
uniprot
proteins
pubmed
25355951
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
31281713
uniprot
proteins
pubmed
31620128
uniprot
proteins
pubmed
32320651
uniprot
proteins
pubmed
33753518
uniprot
proteins
sequence_length
431
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:17344420, ECO:0000269|PubMed:25355951}. Nucleus {ECO:0000269|PubMed:17344420, ECO:0000269|PubMed:25355951}. Mitochondrion {ECO:0000269|PubMed:17344420, ECO:0000269|PubMed:25228397}.
uniprot
proteins