Fbxo39
entrez
628100
canonical
uniprot
Q5NBU5
canonical
ensembl
ENSMUSG00000070388
resolver
ensp
ENSMUSP00000104144
resolver
ensp
ENSMUSP00000353107
resolver
enst
ENSMUST00000108504
resolver
genesymbol
Fbxo39
resolver
uniprot_entry
FBX39_MOUSE
resolver
amino_acid_sequence
MDEDCEVTQLQEQSCWATLPDVCLRRVFWWLGDRDRSRAALVCRKWNQIMYSADLWRYRTITFSGRPSRVHASEFESALWYIKKFGRYLEHLEIKFLNPYNAVLTKKFQVTMRGLLSCLGKSNNRLRSLSIQHLELDRLVWRNSIRGSLIKSLSFFLKKMGKHLDHLSLKGARLTVEQGCHILNSLSYMQNENMASELNIEDFFSHHLAVYGSSQFNKAMATFRNLTFLTLNYNCISDELLETLSENNAGTLRTMNIKCHVHDPHGQVVWGMSWAKLARQASNLKVNFFFERVMKYERLARILLQEIPVRSISLRSCYFSDPDWSMRPTLTDLLPTFRNTLQKLTFEFNNNHESLDEQLHLLILACRKLFYFKIWAFLDVKFVERILKSQEEGQCSLHTLKVRIYTNRYETNEEDRTLREIYRKYRKLIDSELNYFVVAYPMM
uniprot
proteins
function
FUNCTION: Testis-enriched substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (PubMed:41916926). Acts as a critical regulator of spermatogenesis, maintaining mitochondrial homeostasis to inhibit ferroptotic cell death. Mechanistically, targets lysine-specific demethylase 5A (KDM5A) for ubiquitin-dependent degradation. {ECO:0000269|PubMed:41781602, ECO:0000269|PubMed:41916926}.
uniprot
proteins
mass_dalton
52554
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
41781602
uniprot
proteins
pubmed
41916926
uniprot
proteins
sequence_length
443
uniprot
proteins