TRH
entrez
7200
canonical
uniprot
P20396
canonical
ensembl
ENSG00000170893
resolver
ensp
ENSP00000303452
resolver
enst
ENST00000302649
resolver
genesymbol
TRH
resolver
hgnc
HGNC:12298
resolver
uniprot
B2R8R1
resolver
uniprot
Q2TB83
resolver
uniprot_entry
TRH_HUMAN
resolver
uniprot_sec
B2R8R1
resolver
uniprot_sec
Q2TB83
resolver
amino_acid_sequence
MPGPWLLLALALTLNLTGVPGGRAQPEAAQQEAVTAAEHPGLDDFLRQVERLLFLRENIQRLQGDQGEHSASQIFQSDWLSKRQHPGKREEEEEEGVEEEEEEEGGAVGPHKRQHPGRREDEASWSVDVTQHKRQHPGRRSPWLAYAVPKRQHPGRRLADPKAQRSWEEEEEEEEREEDLMPEKRQHPGKRALGGPCGPQGAYGQAGLLLGLLDDLSRSQGAEEKRQHPGRRAAWVREPLEE
uniprot
proteins
function
FUNCTION: As a component of the hypothalamic-pituitary-thyroid axis, it controls the secretion of thyroid-stimulating hormone (TSH) and is involved in thyroid hormone synthesis regulation. It also operates as modulator of hair growth. It promotes hair-shaft elongation, prolongs the hair cycle growth phase (anagen) and antagonizes its termination (catagen) by TGFB2. It stimulates proliferation and inhibits apoptosis of hair matrix keratinocytes. {ECO:0000269|PubMed:19825978}.
uniprot
proteins
mass_dalton
27404
uniprot
proteins
protein_family
TRH family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19825978
uniprot
proteins
pubmed
2126343
uniprot
proteins
sequence_length
242
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins