CALCA
entrez
796
canonical
uniprot
P01258
canonical
uniprot
P06881
canonical
ensembl
ENSG00000110680
resolver
ensp
ENSP00000331746
resolver
ensp
ENSP00000379657
resolver
ensp
ENSP00000417833
resolver
ensp
ENSP00000516203
resolver
ensp
ENSP00000516204
resolver
enst
ENST00000486207
resolver
enst
ENST00000706042
resolver
enst
ENST00000706043
resolver
genesymbol
CALCA
resolver
genesymbol_syn
CALC1
resolver
hgnc
HGNC:1437
resolver
uniprot
B7ZL39
resolver
uniprot
Q13935
resolver
uniprot
Q13937
resolver
uniprot
Q52LX7
resolver
uniprot
Q93048
resolver
uniprot
Q9UCP0
resolver
uniprot_entry
CALCA_HUMAN
resolver
uniprot_entry
CALC_HUMAN
resolver
uniprot_sec
B7ZL39
resolver
uniprot_sec
Q13935
resolver
uniprot_sec
Q13937
resolver
uniprot_sec
Q52LX7
resolver
uniprot_sec
Q93048
resolver
uniprot_sec
Q9UCP0
resolver
amino_acid_sequence
MGFQKFSPFLALSILVLLQAGSLHAAPFRSALESSPADPATLSEDEARLLLAALVQDYVQMKASELEQEQEREGSRIIAQKRACDTATCVTHRLAGLLSRSGGVVKNNFVPTNVGSKAFGRRRRDLQA
uniprot
proteins
amino_acid_sequence
MGFQKFSPFLALSILVLLQAGSLHAAPFRSALESSPADPATLSEDEARLLLAALVQDYVQMKASELEQEQEREGSSLDSPRSKRCGNLSTCMLGTYTQDFNKFHTFPQTAIGVGAPGKKRDMSSDLERDHRPHVSMPQNAN
uniprot
proteins
function
FUNCTION: CGRP1/CALCA is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex (PubMed:1318039, PubMed:33602864, PubMed:9620797). Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role (PubMed:3492492). It also elevates platelet cAMP (PubMed:1318039). CGRP1 can also bind and activate CALCR-RAMP1 (AMYR1) receptor complex (PubMed:38603770). {ECO:0000269|PubMed:1318039, ECO:0000269|PubMed:33602864, ECO:0000269|PubMed:3492492, ECO:0000269|PubMed:38603770, ECO:0000269|PubMed:9620797}.
uniprot
proteins
function
FUNCTION: [Calcitonin]: Calcitonin is a peptide hormone that causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Calcitonin function is mediated by the calcitonin receptor/CALCR and the CALCR-RAMP2 (AMYR2) receptor complex (PubMed:35324283). {ECO:0000269|PubMed:35324283}.; FUNCTION: [Katacalcin]: Katacalcin is a potent plasma calcium-lowering peptide. {ECO:0000269|PubMed:6132180}.
uniprot
proteins
mass_dalton
13899
uniprot
proteins
mass_dalton
15467
uniprot
proteins
protein_family
Calcitonin family
uniprot
proteins
pubmed
1318039
uniprot
proteins
pubmed
14759258
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16554811
uniprot
proteins
pubmed
1761559
uniprot
proteins
pubmed
1988044
uniprot
proteins
pubmed
2001366
uniprot
proteins
pubmed
2039456
uniprot
proteins
pubmed
2408883
uniprot
proteins
pubmed
2571128
uniprot
proteins
pubmed
3034287
uniprot
proteins
pubmed
33602864
uniprot
proteins
pubmed
3485540
uniprot
proteins
pubmed
3492492
uniprot
proteins
pubmed
35324283
uniprot
proteins
pubmed
38603770
uniprot
proteins
pubmed
3872459
uniprot
proteins
pubmed
5760861
uniprot
proteins
pubmed
6132180
uniprot
proteins
pubmed
6148938
uniprot
proteins
pubmed
6546550
uniprot
proteins
pubmed
6609312
uniprot
proteins
pubmed
6610687
uniprot
proteins
pubmed
9620797
uniprot
proteins
sequence_length
128
uniprot
proteins
sequence_length
141
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2408883}.
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted.
uniprot
proteins