TREX2
entrez
11219
canonical
uniprot
Q9BQ50
canonical
ensembl
ENSG00000183479
resolver
ensp
ENSP00000359251
resolver
genesymbol
TREX2
resolver
hgnc
HGNC:12270
resolver
uniprot
Q45F08
resolver
uniprot
Q9UN77
resolver
uniprot_entry
TREX2_HUMAN
resolver
uniprot_sec
Q45F08
resolver
uniprot_sec
Q9UN77
resolver
amino_acid_sequence
MSEAPRAETFVFLDLEATGLPSVEPEIAELSLFAVHRSSLENPEHDESGALVLPRVLDKLTLCMCPERPFTAKASEITGLSSEGLARCRKAGFDGAVVRTLQAFLSRQAGPICLVAHNGFDYDFPLLCAELRRLGARLPRDTVCLDTLPALRGLDRAHSHGTRARGRQGYSLGSLFHRYFRAEPSAAHSAEGDVHTLLLIFLHRAAELLAWADEQARGWAHIEPMYLPPDDPSLEA
uniprot
proteins
ec_number
3.1.11.2
uniprot
proteins
function
FUNCTION: Exonuclease with a preference for double-stranded DNA with mismatched 3' termini. May play a role in DNA repair. {ECO:0000269|PubMed:11279105}.
uniprot
proteins
mass_dalton
25922
uniprot
proteins
mutagenesis
MUTAGEN 14; /note="D->A: Loss of enzyme activity; when associated with A-16. Almost abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:15661738"; MUTAGEN 16; /note="E->A: Loss of enzyme activity; when associated with A-14. Almost abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:15661738"; MUTAGEN 123; /note="D->A: Almost abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:15661738"; MUTAGEN 163; /note="R->A: Strongly reduces DNA-binding; when associated with A-165 and A-167."; /evidence="ECO:0000269|PubMed:15661738"; MUTAGEN 165; /note="R->A: Strongly reduces DNA-binding; when associated with A-163 and A-167."; /evidence="ECO:0000269|PubMed:15661738"; MUTAGEN 167; /note="R->A: Strongly reduces DNA-binding; when associated with A-165 and A-165."; /evidence="ECO:0000269|PubMed:15661738"; MUTAGEN 188; /note="H->A: Loss of enzyme activity; when associated with A-193. Almost abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:15661738"; MUTAGEN 193; /note="D->A: Loss of enzyme activity; when associated with A-188. Almost abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:15661738
uniprot
proteins
protein_family
Exonuclease superfamily
uniprot
proteins
protein_family
TREX family
uniprot
proteins
pubmed
10391904
uniprot
proteins
pubmed
11278605
uniprot
proteins
pubmed
11279105
uniprot
proteins
pubmed
15661738
uniprot
proteins
sequence_length
236
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
uniprot
proteins