Kdm4a
entrez
230674
canonical
uniprot
Q8BW72
canonical
ensembl
ENSMUSG00000033326
resolver
ensp
ENSMUSP00000062910
resolver
ensp
ENSMUSP00000095524
resolver
ensp
ENSMUSP00000102011
resolver
ensp
ENSMUSP00000102014
resolver
ensp
ENSMUSP00000224112
resolver
enst
ENSMUST00000050288
resolver
genesymbol
Kdm4a
resolver
genesymbol_syn
Jhdm3a
resolver
genesymbol_syn
Jmjd2
resolver
genesymbol_syn
Jmjd2a
resolver
genesymbol_syn
Kiaa0677
resolver
uniprot
A2A8L8
resolver
uniprot
A2A8L9
resolver
uniprot
Q3UKM5
resolver
uniprot
Q3UM81
resolver
uniprot
Q3UWV2
resolver
uniprot
Q6ZQ72
resolver
uniprot
Q8K137
resolver
uniprot_entry
A2A8L9_MOUSE
resolver
uniprot_entry
KDM4A_MOUSE
resolver
uniprot_sec
A2A8L8
resolver
uniprot_sec
Q3UKM5
resolver
uniprot_sec
Q3UM81
resolver
uniprot_sec
Q3UWV2
resolver
uniprot_sec
Q6ZQ72
resolver
uniprot_sec
Q8K137
resolver
amino_acid_sequence
MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRTSYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKKAMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEQHVDEWNIGRLKTILDLVEKESGITIEGVNTPYLYFGMWKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMITFPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRRFQPERYKLWKAGKDSMVIDHTLPTPEAAEFLKDSGGLTPRAGSEECPEEDVEAADQGEEGDVKRSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEELSSGQYEMTECPATLAPVRPTHSSVRQVEDSLPFPDYSDPTEVKFEELKNVKLEEEDEEDEPEAAALDLSVNPASVGGRLVFSGSKKKSSSSLGSTSSQDSVSSDSETAESVSCQGQEKTGVLTVHSYARGDGKAATGEPSVKKKRSAPRSISEQELAEVADEYMLSLEENKKTKGRRQPLSKLPRHHPLVLQECGSDDETSEQLTPEEEAEETEAWAKPLSQLWQNRPPNFEAEKEFNEIMAQQAPHCAVCMIFQTYHQVEFGAFSQSCGDASEPAAQTQRTKPLIPEMCFTTTGCSTDINLSTPYLEEDGTSMLVSCKKCSVRVHASCYGVPPAKASEEWMCSRCSANALEEDCCLCSLRGGALQRANDDRWVHVSCAVAILEARFVNIAERSPVDVSKIPLPRFKLKCVFCKKRRKRNAGCCVQCSHGRCPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHKIPNLERAKGALLSITAGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDIVSQDCLQLGPPAEGEVVQVRWTDGQVYGAKFVASHPIQMYQVEFEDGSQLVVKRDDVYTLDEELPKRVKSRLSVASDMRFNEIFTEKEVKQEKKRQRVINSRYREDYIEPALYRAIME
uniprot
proteins
ec_number
1.14.11.66
uniprot
proteins
ec_number
1.14.11.69
uniprot
proteins
function
FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:24953653). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20' (By similarity). Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues (By similarity). Demethylation of Lys residue generates formaldehyde and succinate. Also able to demethylate histone H1-4 methylated at 'Lys-26' (H1.4K26me1, H1.4K26me2 and H1.4K26me3) (By similarity). Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively (By similarity). {ECO:0000250|UniProtKB:O75164, ECO:0000269|PubMed:24953653}.
uniprot
proteins
mass_dalton
120334
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by RNF8 and RNF168, leading to its degradation (PubMed:24953653). Degradation promotes accessibility of H4K20me2 mark for DNA repair protein TP53BP1, which is then recruited (By similarity). Also ubiquitinated by the SCF(FBXO22) complex; leading to proteasomal degradation (By similarity). {ECO:0000250|UniProtKB:O75164, ECO:0000269|PubMed:24953653}.
uniprot
proteins
protein_family
JHDM3 histone demethylase family
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16024779
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
24953653
uniprot
proteins
sequence_length
1064
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00537}.
uniprot
proteins