Hcn4
entrez
330953
canonical
uniprot
O70507
canonical
ensembl
ENSMUSG00000032338
resolver
ensp
ENSMUSP00000034889
resolver
enst
ENSMUST00000034889
resolver
genesymbol
Hcn4
resolver
genesymbol_syn
Bcng3
resolver
uniprot
B2RY58
resolver
uniprot_entry
HCN4_MOUSE
resolver
uniprot_sec
B2RY58
resolver
activity_regulation
ACTIVITY REGULATION: Activated by cAMP, and to a lesser extent by cGMP and cCMP (PubMed:22715094). cAMP binding causes a conformation change that leads to the assembly of an active tetramer and channel opening. Binding of cAMP removes a tonic inhibition conferred by cyclic nucleotide-binding domain (CNBD) on channel opening. Cyclic dinucleotides can modulate HCN4 channel; cyclic dinucleotides acting as potent antagonists of cAMP. Inhibited by extracellular Cs(+) ions (By similarity). Auxiliary subunits can also regulate HCN4 channel. IRAG1 causes a gain-of-function by shifting HCN4 activation to more depolarized membrane potentials in the absence of cAMP. In contrast, IRAG2 causes a loss-of-function by inhibiting cAMP-dependent potentiation of HCN4 activation (PubMed:32647060). {ECO:0000250|UniProtKB:Q9Y3Q4, ECO:0000269|PubMed:22715094, ECO:0000269|PubMed:32647060}.
uniprot
proteins
amino_acid_sequence
MDKLPPSMRKRLYSLPQQVGAKAWIMDEEEDGEEEGAGGRQDPSRRSIRLRPLPSPSPSVAAGCSESRGAALGATESEGPGRSAGKSSTNGDCRRFRGSLASLGSRGGGSGGAGGGSSLGHLHDSAEERRLIAAEGDASPGEDRTPPGLATEPERPATAAQPAASPPPQQPPQPASASCEQPSADTAIKVEGGAAASDQILPEAEVRLGQSGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFVVDFISSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPHDCWVSINGMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILLHKVQHDLNSGVFNYQENEIIQQIVRHDREMAHCAHRVQAAASATPTPTPVIWTPLIQAPLQAAAATTSVAIALTHHPRLPAAIFRPPPGPGLGNLGAGQTPRHPRRLQSLIPSALGSASPASSPSQVDTPSSSSFHIQQLAGFSAPPGLSPLLPSSSSSPPPGACGSPPAPTPSTSTAAAASTTGFGHFHKALGGSLSSSDSPLLTPLQPGARSPQAAQPPPPLPGARGGLGLLEHFLPPPPSSRSPSSSPGQLGQPPGELSLGLAAGPSSTPETPPRPERPSFMAGASGGASPVAFTPRGGLSPPGHSPGPPRTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLTPGRLTQDLKLISASQPALPQDGAQTLRRASPHSSGESVAAFSLYPRAGGGSGSSGGLGPPGRPYGAIPGQHVTLPRKTSSGSLPPPLSLFGARAASSGGPPLTTAAPQREPGARSEPVRSKLPSNL
uniprot
proteins
function
FUNCTION: Hyperpolarization-activated ion channel that are permeable to Na(+) and K(+) ions with very slow activation and inactivation. Exhibits higher selectivity for K(+) over Na(+) ions (By similarity). Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat (PubMed:14657344, PubMed:21220308). Contributes to the native pacemaker currents in neurons (Ih) (By similarity). May mediate responses to sour stimuli (PubMed:11675786). {ECO:0000250|UniProtKB:Q9Y3Q4, ECO:0000269|PubMed:11675786, ECO:0000269|PubMed:14657344, ECO:0000269|PubMed:21220308}.
uniprot
proteins
mass_dalton
129065
uniprot
proteins
post_translational_modification
PTM: S-palmitoylated. {ECO:0000250|UniProtKB:Q9Y3Q4}.
uniprot
proteins
protein_family
Potassium channel HCN family
uniprot
proteins
pubmed
11675786
uniprot
proteins
pubmed
14657344
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21220308
uniprot
proteins
pubmed
22715094
uniprot
proteins
pubmed
32647060
uniprot
proteins
pubmed
9630217
uniprot
proteins
sequence_length
1201
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11675786}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9Y3Q4}.
uniprot
proteins
transmembrane_region
TRANSMEM 264..286; /note="Helical; Name=Segment S1"; /evidence="ECO:0000250|UniProtKB:Q9Y3Q4"; TRANSMEM 294..314; /note="Helical; Name=Segment S2"; /evidence="ECO:0000250|UniProtKB:Q9Y3Q4"; TRANSMEM 337..359; /note="Helical; Name=Segment S3"; /evidence="ECO:0000250|UniProtKB:Q9Y3Q4"; TRANSMEM 379..399; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000250|UniProtKB:Q9Y3Q4"; TRANSMEM 414..436; /note="Helical; Name=Segment S5"; /evidence="ECO:0000250|UniProtKB:Q9Y3Q4"; TRANSMEM 492..517; /note="Helical; Name=Segment S6"; /evidence="ECO:0000250|UniProtKB:Q9Y3Q4
uniprot
proteins