Slc10a2
entrez
20494
canonical
uniprot
P70172
canonical
ensembl
ENSMUSG00000023073
resolver
ensp
ENSMUSP00000023835
resolver
enst
ENSMUST00000023835
resolver
genesymbol
Slc10a2
resolver
genesymbol_syn
Ntcp2
resolver
uniprot
Q0VBB8
resolver
uniprot
Q8VI83
resolver
uniprot
Q925U7
resolver
uniprot_entry
NTCP2_MOUSE
resolver
uniprot_entry
Q0VBB8_MOUSE
resolver
uniprot_sec
Q8VI83
resolver
uniprot_sec
Q925U7
resolver
amino_acid_sequence
MDNSSVCPPNATVCEGDSCVVPESNFNAILNTVMSTVLTILLAMVMFSMGCNVEVHKFLGHIKRPWGIFVGFLCQFGIMPLTGFILSVASGILPVQAVVVLIMGCCPGGTGSNILAYWIDGDMDLSVSMTTCSTLLALGMMPLCLFVYTKMWVDSGTIVIPYDSIGISLVALVIPVSFGMFVNHKWPQKAKIILKIGSITGVILIVLIAVIGGILYQSAWIIEPKLWIIGTIFPIAGYSLGFFLARLAGQPWYRCRTVALETGMQNTQLCSTIVQLSFSPEDLNLVFTFPLIYTVFQLVFAAVILGIYVTYRKCYGKNDAEFLEKTDNEMDSRPSFDETNKGFQPDEK
uniprot
proteins
function
FUNCTION: Plays a critical role in the sodium-dependent reabsorption of bile acids from the lumen of the small intestine (PubMed:10101301). Transports various bile acids, unconjugated or conjugated, such as cholate and taurocholate (PubMed:10101301). Also responsible for bile acid transport in the renal proximal tubules, a salvage mechanism that helps conserve bile acids. Works collaboratively with the Na(+)-taurocholate cotransporting polypeptide (NTCP), the organic solute transporter (OST), and the bile salt export pump (BSEP), to ensure efficacious biological recycling of bile acids during enterohepatic circulation (By similarity). {ECO:0000250|UniProtKB:Q12908, ECO:0000269|PubMed:10101301}.
uniprot
proteins
mass_dalton
38134
uniprot
proteins
protein_family
Bile acid:sodium symporter (BASS) (TC 2.A.28) family
uniprot
proteins
pubmed
10101301
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
348
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 29..49; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 88..108; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 127..147; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 158..178; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 196..216; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 225..245; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 285..305; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins