Nme7
entrez
171567
canonical
uniprot
Q9QXL8
canonical
ensembl
ENSMUSG00000026575
resolver
ensp
ENSMUSP00000083192
resolver
ensp
ENSMUSP00000141431
resolver
ensp
ENSMUSP00000141771
resolver
ensp
ENSMUSP00000141963
resolver
ensp
ENSMUSP00000205932
resolver
enst
ENSMUST00000086028
resolver
enst
ENSMUST00000191947
resolver
enst
ENSMUST00000193683
resolver
enst
ENSMUST00000193808
resolver
genesymbol
Nme7
resolver
uniprot
F6XDV7
resolver
uniprot
Q3UMG6
resolver
uniprot
Q8BUH2
resolver
uniprot_entry
F6XDV7_MOUSE
resolver
uniprot_entry
NDK7_MOUSE
resolver
uniprot_entry
Q8BUH2_MOUSE
resolver
uniprot_sec
Q3UMG6
resolver
amino_acid_sequence
MRACQQGRSSSLVSPYMAPKNQSERFAFIAEWYDPNASLLRRYELLFYPTDGSVEMHDVKNRRTFLKRTKYEDLRLEDLFIGNKVNVFSRQLVLIDYGDQYTARQLGSRKEKTLALIKPDAVSKAGEIIEMINKSGFTITKLRMMTLTRKEAADFHVDHHSRPFYNELIQFITSGPVIAMEILRDDAICEWKRLLGPANSGLSRTDAPGSIRALFGTDGVRNAAHGPDTFASAAREMELFFPSSGGCGPANTAKFTNCTCCIIKPHAISEGMLGKILIAIRDACFGMSAIQMFNLDRANVEEFYEVYKGVVSEYNDMVTELCSGPCVAIEIQQSNPTKTFREFCGPADPEIARHLRPETLRAIFGKTKVQNAVHCTDLPEDGLLEVQYFFKILDN
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
ec_number
3.1.11.-
uniprot
proteins
function
FUNCTION: Possesses an intrinsic kinase activity. Phosphorylates GSK3B at 'Ser-9', leading to the activation of Wnt/beta-catenin signaling. Additionally, exhibits a 3'-5'-DNA exonuclease activity that removes single nucleotides from the 3' terminus of single-stranded DNA substrates and digests overhanging mismatched 3' termini from double-stranded DNA substrates, possibly participating in DNA nucleolytic processing. In vitro, does not seem to have nucleoside diphosphate kinase activity. Functional component of the gamma-tubulin ring complex, implicated in the regulation of its microtubule-nucleating activity in centrosomes, in a kinase activity-dependent manner (By similarity). May maintain primary cilium assembly and ciliary microtubule stability (PubMed:39824631). Part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, required for motile cilia beating (PubMed:37295417, PubMed:37865089, PubMed:37989994). {ECO:0000250|UniProtKB:Q9Y5B8, ECO:0000269|PubMed:37295417, ECO:0000269|PubMed:37865089, ECO:0000269|PubMed:37989994, ECO:0000269|PubMed:39824631}.
uniprot
proteins
mass_dalton
44435
uniprot
proteins
protein_family
NDK family
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20080492
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
37295417
uniprot
proteins
pubmed
37865089
uniprot
proteins
pubmed
37989994
uniprot
proteins
pubmed
39824631
uniprot
proteins
sequence_length
395
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:39824631}. Nucleus {ECO:0000250|UniProtKB:Q9Y5B8}. Cytoplasm {ECO:0000250|UniProtKB:Q9Y5B8}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9Y5B8}. Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:Q9Y5B8}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:37295417, ECO:0000269|PubMed:37865089, ECO:0000269|PubMed:37989994}. Cell projection, cilium {ECO:0000269|PubMed:39824631}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000269|PubMed:39824631}. Note=Localizes to centrosomes through its assembly into gamma-tubulin ring complex. The centrosomal content of NME7 varies during the cell cycle, being highest in mitosis and lowest in early G1 (By similarity). Localizes at the cilium basal body during cilium assembly (PubMed:39824631). {ECO:0000250|UniProtKB:Q9Y5B8, ECO:0000269|PubMed:39824631}.
uniprot
proteins