COX5B
entrez
1329
canonical
uniprot
P10606
canonical
ensembl
ENSG00000135940
resolver
ensembl
ENSG00000291596
resolver
ensp
ENSP00000258424
resolver
ensp
ENSP00000517083
resolver
enst
ENST00000258424
resolver
enst
ENST00000708077
resolver
genesymbol
COX5B
resolver
hgnc
HGNC:2269
resolver
uniprot
A0A384NL93
resolver
uniprot
Q53YB7
resolver
uniprot
Q96J18
resolver
uniprot
Q99610
resolver
uniprot_entry
A0A384NL93_HUMAN
resolver
uniprot_entry
COX5B_HUMAN
resolver
uniprot_sec
Q53YB7
resolver
uniprot_sec
Q96J18
resolver
uniprot_sec
Q99610
resolver
amino_acid_sequence
MASRLLRGAGTLAAQALRARGPSGAAAMRSMASGGGVPTDEEQATGLEREIMLAAKKGLDPYNVLAPKGASGTREDPNLVPSISNKRIVGCICEEDNTSVVWFWLHKGEAQRCPRCGAHYKLVPQQLAH
uniprot
proteins
function
FUNCTION: Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix. {ECO:0000250|UniProtKB:P04037}.
uniprot
proteins
mass_dalton
13696
uniprot
proteins
pathway_participation
PATHWAY: Energy metabolism; oxidative phosphorylation. {ECO:0000250|UniProtKB:P04037}.
uniprot
proteins
protein_family
Cytochrome c oxidase subunit 5B family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
1646156
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
2840351
uniprot
proteins
pubmed
28844695
uniprot
proteins
pubmed
30030519
uniprot
proteins
pubmed
8313870
uniprot
proteins
pubmed
8806766
uniprot
proteins
sequence_length
129
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000269|PubMed:30030519}; Peripheral membrane protein {ECO:0000269|PubMed:30030519}; Matrix side {ECO:0000269|PubMed:30030519}.
uniprot
proteins