Ang
entrez
11727
canonical
uniprot
P21570
canonical
ensembl
ENSMUSG00000072115
resolver
ensp
ENSMUSP00000067434
resolver
ensp
ENSMUSP00000132084
resolver
enst
ENSMUST00000069011
resolver
enst
ENSMUST00000171688
resolver
genesymbol
Ang
resolver
genesymbol_syn
Ang1
resolver
genesymbol_syn
Rnase5
resolver
genesymbol_syn
Rnase5a
resolver
uniprot
Q3TBG7
resolver
uniprot_entry
ANGI_MOUSE
resolver
uniprot_entry
Q3TBG7_MOUSE
resolver
activity_regulation
ACTIVITY REGULATION: Has weak tRNA ribonuclease activity by itself due to partial autoinhibition by its C-terminus (residues 139-145), which folds into a short alpha-helix that partially occludes the substrate-binding site (By similarity). In absence of stress, the ribonuclease activity is inhibited by RNH1 in the cytoplasm (By similarity). In response to stress, dissociates from RNH1 in the cytoplasm and associates with cytoplasmic ribosomes with vacant A-sites: ribosomes directly activate the tRNA ribonuclease activity of ANG by refolding the C-terminal alpha-helix (By similarity). In response to stress, the angiogenic activity of ANG is inhibited by RNH1 in the nucleus (By similarity). {ECO:0000250|UniProtKB:P03950}.
uniprot
proteins
amino_acid_sequence
MAISPGPLFLIFVLGLVVIPPTLAQDDSRYTKFLTQHHDAKPKGRDDRYCERMMKRRSLTSPCKDVNTFIHGNKSNIKAICGANGSPYRENLRMSKSPFQVTTCKHTGGSPRPPCQYRASAGFRHVVIACENGLPVHFDESFFSL
uniprot
proteins
ec_number
3.1.27.-
uniprot
proteins
function
FUNCTION: Secreted ribonuclease that can either promote or restrict cell proliferation of target cells, depending on the context (PubMed:19114040, PubMed:27518564, PubMed:32510170, PubMed:33758201, PubMed:33986151). Endocytosed in target cells via its receptor PLXNB2 and translocates to the cytoplasm or nucleus (PubMed:29100074, PubMed:33758201). Under stress conditions, localizes to the cytoplasm and promotes the assembly of stress granules (SGs): specifically cleaves a subset of tRNAs within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs), resulting in translation repression and inhibition of cell proliferation (PubMed:19114040, PubMed:24752898, PubMed:33986151). tiRNas also prevent formation of apoptosome, thereby promoting cell survival (PubMed:24752898). Preferentially cleaves RNAs between a pyrimidine and an adenosine residue, suggesting that it cleaves the anticodon loop of tRNA(Ala) (32-UUAGCAU-38) after positions 33 and 36 (By similarity). Cleaves a subset of tRNAs, including tRNA(Ala), tRNA(Glu), tRNA(Gly), tRNA(Lys), tRNA(Val), tRNA(His), tRNA(Asp) and tRNA(Sec) (By similarity). Under growth conditions and in differentiated cells, translocates to the nucleus and stimulates ribosomal RNA (rRNA) transcription, including that containing the initiation site sequences of 45S rRNA, thereby promoting cell growth and proliferation (By similarity). Angiogenin induces vascularization of normal and malignant tissues via its ability to promote rRNA transcription (By similarity). Involved in hematopoietic stem and progenitor cell (HSPC) growth and survival by promoting rRNA transcription in growth conditions and inhibiting translation in response to stress, respectively (PubMed:27518564). Mediates the crosstalk between myeloid and intestinal epithelial cells to protect the intestinal epithelial barrier integrity: secreted by myeloid cells and promotes intestinal epithelial cells proliferation and survival (PubMed:32510170). Also mediates osteoclast-endothelial cell crosstalk in growing bone: produced by osteoclasts and protects the neighboring vascular cells against senescence by promoting rRNA transcription (PubMed:33758201). {ECO:0000250|UniProtKB:P03950, ECO:0000269|PubMed:19114040, ECO:0000269|PubMed:24752898, ECO:0000269|PubMed:27518564, ECO:0000269|PubMed:29100074, ECO:0000269|PubMed:32510170, ECO:0000269|PubMed:33758201, ECO:0000269|PubMed:33986151}.
uniprot
proteins
mass_dalton
16228
uniprot
proteins
protein_family
Pancreatic ribonuclease family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16301790
uniprot
proteins
pubmed
19114040
uniprot
proteins
pubmed
2222458
uniprot
proteins
pubmed
24752898
uniprot
proteins
pubmed
27518564
uniprot
proteins
pubmed
29100074
uniprot
proteins
pubmed
32510170
uniprot
proteins
pubmed
33758201
uniprot
proteins
pubmed
33986151
uniprot
proteins
pubmed
8448182
uniprot
proteins
sequence_length
145
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:33758201}. Nucleus {ECO:0000269|PubMed:33758201}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P03950}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:P03950}. Note=The secreted protein is rapidly endocytosed by target cells following interaction with PLXNB2 receptor and translocated to the cytoplasm and nucleus (PubMed:33758201). In the nucleus, accumulates in the nucleolus and binds to DNA (By similarity). {ECO:0000250|UniProtKB:P03950, ECO:0000269|PubMed:33758201}.
uniprot
proteins