Fnbp1
entrez
14269
canonical
uniprot
Q80TY0
canonical
ensembl
ENSMUSG00000075415
resolver
ensp
ENSMUSP00000097781
resolver
ensp
ENSMUSP00000097782
resolver
ensp
ENSMUSP00000109181
resolver
ensp
ENSMUSP00000109184
resolver
ensp
ENSMUSP00000109188
resolver
ensp
ENSMUSP00000109189
resolver
ensp
ENSMUSP00000109190
resolver
ensp
ENSMUSP00000109192
resolver
ensp
ENSMUSP00000109194
resolver
ensp
ENSMUSP00000172844
resolver
ensp
ENSMUSP00000172847
resolver
ensp
ENSMUSP00000172848
resolver
ensp
ENSMUSP00000172851
resolver
ensp
ENSMUSP00000172854
resolver
ensp
ENSMUSP00000172855
resolver
ensp
ENSMUSP00000172858
resolver
ensp
ENSMUSP00000172859
resolver
ensp
ENSMUSP00000172860
resolver
ensp
ENSMUSP00000172861
resolver
ensp
ENSMUSP00000172862
resolver
ensp
ENSMUSP00000337418
resolver
enst
ENSMUST00000073879
resolver
enst
ENSMUST00000100207
resolver
enst
ENSMUST00000100208
resolver
enst
ENSMUST00000113555
resolver
genesymbol
Fnbp1
resolver
genesymbol_syn
Fbp17
resolver
genesymbol_syn
Kiaa0554
resolver
uniprot
A2AQ40
resolver
uniprot
A2AQ41
resolver
uniprot
A2AQ43
resolver
uniprot
A2AQ44
resolver
uniprot
A2AQ45
resolver
uniprot
A2AQ46
resolver
uniprot
Q3TA45
resolver
uniprot
Q3TCW9
resolver
uniprot
Q3U081
resolver
uniprot
Q3UPI7
resolver
uniprot
Q8C727
resolver
uniprot
Q99L37
resolver
uniprot_entry
A2AQ41_MOUSE
resolver
uniprot_entry
A2AQ43_MOUSE
resolver
uniprot_entry
A2AQ44_MOUSE
resolver
uniprot_entry
A2AQ45_MOUSE
resolver
uniprot_entry
FNBP1_MOUSE
resolver
uniprot_sec
A2AQ40
resolver
uniprot_sec
A2AQ46
resolver
uniprot_sec
Q3TA45
resolver
uniprot_sec
Q3TCW9
resolver
uniprot_sec
Q3U081
resolver
uniprot_sec
Q3UPI7
resolver
uniprot_sec
Q8C727
resolver
uniprot_sec
Q99L37
resolver
amino_acid_sequence
MSWGTELWDQFDNLEKHTQWGIDILEKYIKFVKERTEIELSYAKQLRNLSKKYQPKKNSKEEEEYKYTACKAFLSTLNEMNDYAGQHEVISENMTSQITVDLMRYVQELKQERKSNFHDGRKAQQHIETCWKQLESSKRRFERDCKEADRAQQYFEKMDADINVTKADVEKARQQAQIRQQMAEDSKADYSLILQRFNQEQWEYYHTHIPNIFQKIQEMEERRIVRIGESMKTYAEVDRQVIPIIGKCLDGIVKAAESIDQKNDSQLVVEAYKSGFEPPGDIEFEDYTQPMKRTVSDNSLSSSKEGKPELRFGGKSRGKLWPFIKKNKLMSLLTSPHQPPPPPPASASPSAVPNGPQSPKQPKEPLSHRFNEFMTSKPKIHCFRSLKRGLSLKLGVTPEDFSNFPPEQRRKKLQQKVDDLNREIQKETDQRDAITKMKDVYLKNPQMGDPASLDQKLTEVTQNIEKLRLEAQKFEAWLAEVEGRLPARSEQARRQSGLYDGQTHQTVTNCAQDRESPDGSYTEEQSQESEHKVLAPDFDDEFDDEEPLPAIGTCKALYTFEGQNEGTISVVEGETLSVIEEDKGDGWTRIRRNEDEEGYVPTSYVEVYLDKNAKGS
uniprot
proteins
function
FUNCTION: Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May act as a link between RND2 signaling and regulation of the actin cytoskeleton. May be required for the lysosomal retention of FASLG/FASL (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
71344
uniprot
proteins
protein_family
FNBP1 family
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15252009
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
616
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, cell cortex {ECO:0000250}. Lysosome {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Membrane, clathrin-coated pit {ECO:0000250}. Note=Enriched in cortical regions coincident with F-actin. Also localizes to endocytic vesicles and lysosomes. {ECO:0000250}.
uniprot
proteins