Chst10
entrez
98388
canonical
uniprot
Q6PGK7
canonical
ensembl
ENSMUSG00000026080
resolver
ensp
ENSMUSP00000027249
resolver
ensp
ENSMUSP00000223755
resolver
enst
ENSMUST00000027249
resolver
genesymbol
Chst10
resolver
uniprot
A2RSS2
resolver
uniprot
F8WIW4
resolver
uniprot
Q8BKU3
resolver
uniprot
Q8BL08
resolver
uniprot
Q8R2Y5
resolver
uniprot
Q91Y40
resolver
uniprot_entry
A2RSS2_MOUSE
resolver
uniprot_entry
CHSTA_MOUSE
resolver
uniprot_entry
F8WIW4_MOUSE
resolver
uniprot_sec
Q8BKU3
resolver
uniprot_sec
Q8BL08
resolver
uniprot_sec
Q8R2Y5
resolver
uniprot_sec
Q91Y40
resolver
amino_acid_sequence
MHHQWLLLAACFWVIFMFMVASKFITLTFKDPDGYSAKQEFVFLTTMPEAEKLRGEKHFPEVPKPTGKMLSDSRPDQPPVYLERLELIRNTCKEEALRNLSHTEVSKFVLDRIFVCDKHKILFCQTPKVGNTQWKKVLIVLNGAFSSIEEIPENVVHDHEKNGLPRLSSFSKIGIQKRLKTYFKFFIVRDPFERLISAFKDKFVHNPRFEPWYRHEIAPGIIRKYRKNRTETRGIQFEDFVRYLGDPNRRWLDLQFGDHIIHWVTYVELCAPCEIKYSVVGHHETLEADAPYILKEAGIDHLVSYPTIPPGITMYNRTKVEQYFLGISKRDIRRLYARFEGDFKLFGYQKPDFLLN
uniprot
proteins
ec_number
2.8.2.-
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of sulfate from 3'-phosphoadenylyl sulfate (PAPS) to position 3 of terminal glucuronic acid of both protein- and lipid-linked oligosaccharides. Participates in biosynthesis of HNK-1 carbohydrate structure 3-O-sulfo-beta-D-GlcA-(1->3)-beta-D-Gal-(1->4)-D-GlcNAc-R, a sulfated glucuronyl-lactosaminyl residue carried by many neural recognition molecules, which is involved in cell interactions during ontogenetic development and in synaptic plasticity in the adult. May be indirectly involved in synapse plasticity of the hippocampus, via its role in HNK-1 biosynthesis (PubMed:12213450, PubMed:12358771). Sulfates terminal glucuronyl residue of the laminin globular (LG)-domain binding epitope on DAG1/alpha-dystroglycan and prevents further polymerization by LARGE1 glycosyltransferase. Likely defines the chain length of LG epitope, conferring binding specificity to extracellular matrix components (By similarity). Plays a role in down-regulating the steroid hormones. Sulfates glucuronidated estrogens and androgens with an impact in hormone cycle and fertility. Has a preference for glucuronyl moiety at the 3-hydroxyl group of a sterol ring rather than the 17-hydroxyl group, showing high catalytic efficiency for 17beta-estradiol 3-O-(beta-D-glucuronate) and dehydroepiandrosterone 3-O-(beta-D-glucuronate) hormones (By similarity) (PubMed:23269668). {ECO:0000250|UniProtKB:O43529, ECO:0000269|PubMed:12213450, ECO:0000269|PubMed:12358771, ECO:0000269|PubMed:23269668}.
uniprot
proteins
mass_dalton
42055
uniprot
proteins
pathway_participation
PATHWAY: Steroid metabolism. {ECO:0000250|UniProtKB:O43529}.; PATHWAY: Protein modification; carbohydrate sulfation. {ECO:0000250|UniProtKB:O43529}.
uniprot
proteins
protein_family
Sulfotransferase 2 family
uniprot
proteins
pubmed
12213450
uniprot
proteins
pubmed
12358771
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
23269668
uniprot
proteins
sequence_length
356
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250|UniProtKB:O54702}; Single-pass type II membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 7..27; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins