Gnas
entrez
14683
canonical
uniprot
P63094
canonical
uniprot
Q6R0H6
canonical
uniprot
Q6R0H7
canonical
uniprot
Q9Z0F1
canonical
ensembl
ENSMUSG00000027523
resolver
ensp
ENSMUSP00000079341
resolver
ensp
ENSMUSP00000085179
resolver
ensp
ENSMUSP00000085184
resolver
ensp
ENSMUSP00000085185
resolver
ensp
ENSMUSP00000104712
resolver
ensp
ENSMUSP00000104713
resolver
ensp
ENSMUSP00000104715
resolver
ensp
ENSMUSP00000104716
resolver
ensp
ENSMUSP00000104724
resolver
ensp
ENSMUSP00000136180
resolver
ensp
ENSMUSP00000139839
resolver
ensp
ENSMUSP00000158707
resolver
ensp
ENSMUSP00000158758
resolver
ensp
ENSMUSP00000173832
resolver
enst
ENSMUST00000109084
resolver
enst
ENSMUST00000109088
resolver
enst
ENSMUST00000156623
resolver
enst
ENSMUST00000186907
resolver
genesymbol
Gnas
resolver
genesymbol_syn
Gnas1
resolver
uniprot
A0A571BEI3
resolver
uniprot
A2A607
resolver
uniprot
A2A608
resolver
uniprot
A2A611
resolver
uniprot
A2A612
resolver
uniprot
A2A613
resolver
uniprot
A6PW72
resolver
uniprot
P04894
resolver
uniprot
P08755
resolver
uniprot
Q3KQM5
resolver
uniprot
Q3TFV3
resolver
uniprot
Q3TWS9
resolver
uniprot
Q3UI70
resolver
uniprot
Q58E62
resolver
uniprot
Q6P7U9
resolver
uniprot
Q6R0H4
resolver
uniprot
Q6R0H5
resolver
uniprot
Q6R2J5
resolver
uniprot
Q80ZK6
resolver
uniprot
Q8BIR3
resolver
uniprot
Q8K5E1
resolver
uniprot
Q9JJX0
resolver
uniprot
Q9QXW5
resolver
uniprot
Q9Z0H2
resolver
uniprot
Q9Z1N8
resolver
uniprot
Q9Z1R7
resolver
uniprot
Z4YKV1
resolver
uniprot_entry
A0A571BEI3_MOUSE
resolver
uniprot_entry
ALEX_MOUSE
resolver
uniprot_entry
GNAS1_MOUSE
resolver
uniprot_entry
GNAS2_MOUSE
resolver
uniprot_entry
GNAS3_MOUSE
resolver
uniprot_entry
Z4YKV1_MOUSE
resolver
uniprot_sec
A2A607
resolver
uniprot_sec
A2A608
resolver
uniprot_sec
A2A611
resolver
uniprot_sec
A2A612
resolver
uniprot_sec
A2A613
resolver
uniprot_sec
A6PW72
resolver
uniprot_sec
P04894
resolver
uniprot_sec
P08755
resolver
uniprot_sec
Q3KQM5
resolver
uniprot_sec
Q3TFV3
resolver
uniprot_sec
Q3TWS9
resolver
uniprot_sec
Q3UI70
resolver
uniprot_sec
Q58E62
resolver
uniprot_sec
Q6P7U9
resolver
uniprot_sec
Q6R0H4
resolver
uniprot_sec
Q6R0H5
resolver
uniprot_sec
Q6R2J5
resolver
uniprot_sec
Q80ZK6
resolver
uniprot_sec
Q8BIR3
resolver
uniprot_sec
Q8K5E1
resolver
uniprot_sec
Q9JJX0
resolver
uniprot_sec
Q9QXW5
resolver
uniprot_sec
Q9Z0H2
resolver
uniprot_sec
Q9Z1N8
resolver
uniprot_sec
Q9Z1R7
resolver
amino_acid_sequence
MDRRSRAQQWRRARHNYNDLCPPIGRRAATALLWLSCSIALLRALASSNARAQQRAAQRRSFLNAHHRSAAAAAAAQVLPESSESESDHEHEEVEPELARPECLEYDQDDYETETDSETEPESDIESETEIETEPETEPETAPTTEPETEPEDERGPRGATFNQSLTQRLHALKLQSADASPRRAQPTTQEPESASEGEEPQRGPLDQDPRDPEEEPEERKEENRQPRRCKTRRPARRRDQSPESPPRKGPIPIRRH
uniprot
proteins
amino_acid_sequence
MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPNFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL
uniprot
proteins
amino_acid_sequence
MGMFNCLHGNNMSGQHDIPPEVGEQPEQEPLEAPGAAAPGAGAGPAEEMATEPDSEPSNNEPVPDETGSEISGPPEDSKSDIQSPCQAFEEVRVGGDYSPPPEEAMPFETQQPSLGDFWPTLEQPGPSGTPSGLQAFNPAILEPGTPTGASPGLGAYTPPPEEAMPFEFNEPAQGDHSQPPLQVPDLAPGGPEALVPRALPAEPGNIRFENAGFREDYSPPPEESVPFQVGGEEFGGDSPPPGLPRVIPQIGIGGEFPTVAVPSALCLAPAENAPPLWVRGAIDRPFREAVRSPPNFACDSPPMEITRPLLEIGRASIGVDDDTAVNMDSPPIASDGPPIEVSGAPDKSECAERPPVEREAAEMEGSPTTATAVEGKVPSPERGDGSSTQPEAMDAKPAPAAQAVSTGSDAGAPTDSAMLTDSQSDAGEDGTAPGTPSDLQSDPEELEEAPAVRADPDGGAAPVAPATPAESESEGSRDPAAEPASEAVPATTAESASGAAPVTQVEPAAAAVSATLAEPAARAAPITPKEPTTRAVPSARAHPAAGAVPGAPAMSASARAAAARAAYAGPLVWGARSLSATPAARASLPARAAAAARAASAARAVAAGRSASAAPSRAHLRPPSPEIQVADPPTPRPPPRPTAWPDKYERGRSCCRYEASSGICEIESSSDESEEGATGCFQWLLRRNRRPGLPRSHTVGSNPVRNFFTRAFGSCFGLSECTRSRSLSPGKAKDPMEERRKQMRKEAIEMREQKRADKKRSKLIDKQLEEEKMDYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNVPNFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL
uniprot
proteins
amino_acid_sequence
MSPSPTRLAVRSVDPQKTPNLTSKAPARPSRKSEWVETTAHLRRKPCHSRHNSPAWEISGPPWSSQDHLGPHQASKPSTQRFWSPGPPLARAQAWEPIPPHQKKLCHLSSTSLPRETIASLPCKSQTLRQEVRKHWSPELFPRSPGTSDLKTLASEKTTALPLKNLCHFRSVEKNSGAIAHPQDSRESSHKSALAASSRQSRSRVRSASLPPRTRLPSGSEAPLTDHSARLSDLLLTSHATAPRWRSPDPCLRLAEPPLGSTTTPLSIWTAPQSQVMARPSKSREPQIRASAQRDPQLSEKQPRWKEALPPPLRWKEKSPLRREGTDLPPSLKQWMPSQPLLPKPSLPDLMLELLRIPRCSQIARAMPEKTGQPQERLQISSRILKNSKKPQLSAPILTEGQPQSPQPLLPSPSLKAAEIQPPSQPPRQSLPPRPSLPPGQPLSPRWSPQPRQSLPPWRSLPPGQPLSPPRSPLPGQSPLLEPIRPLEQSLAPQQCQPLLGQLPLGQPMQVHWSGEPGHSQLLPPLGHPFLPAQQLPPGQPLLPAQSLLAGQPLPPPAGPILDPPAPRSRLLTRLLRGLLRGRLPGLTSTSGAEAAAGTRHRLASARSSPPVMSRKKGPPAASSGFCGETAALACPGATRSGATQSATSSPEPSEAASVYPSVPDHDPSAPGRPRILWRRGANRCAKKPLRCESRSAQIRNAASSSTSNWRRRRWTTCVHTACCF
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:12145344). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:12145344). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:12145344). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:12145344). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:12145344). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:12145344). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors (PubMed:12145344). XLas isoforms interact with the same set of receptors as Gnas isoforms (PubMed:12145344). {ECO:0000269|PubMed:12145344}.
uniprot
proteins
function
FUNCTION: Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:21467038). The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state (PubMed:21467038). Signaling by an activated GPCR promotes GDP release and GTP binding (PubMed:21467038). The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal (PubMed:21467038). Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (By similarity). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (By similarity). Functions downstream of beta-adrenergic receptors (By similarity). Stimulates the Ras signaling pathway via RAPGEF2 (By similarity). {ECO:0000250|UniProtKB:P63092, ECO:0000269|PubMed:21467038}.
uniprot
proteins
function
FUNCTION: May inhibit the adenylyl cyclase-stimulating activity of guanine nucleotide-binding protein G(s) subunit alpha which is produced from the same locus in a different open reading frame. {ECO:0000250|UniProtKB:P84996}.
uniprot
proteins
mass_dalton
121505
uniprot
proteins
mass_dalton
29301
uniprot
proteins
mass_dalton
45664
uniprot
proteins
mass_dalton
79084
uniprot
proteins
mutagenesis
MUTAGEN 3; /note="C->S: Abolishes S-palmitoylation."; /evidence="ECO:0000269|PubMed:8227063
uniprot
proteins
post_translational_modification
PTM: Binds keratan sulfate chains. {ECO:0000250|UniProtKB:O18979}.; PTM: May be proteolytically processed to give rise to a number of active peptides. {ECO:0000250|UniProtKB:O18979}.
uniprot
proteins
protein_family
ALEX family
uniprot
proteins
protein_family
G(s) subfamily
uniprot
proteins
protein_family
G-alpha family
uniprot
proteins
protein_family
NESP55 family
uniprot
proteins
pubmed
10610704
uniprot
proteins
pubmed
10716699
uniprot
proteins
pubmed
10749992
uniprot
proteins
pubmed
10931851
uniprot
proteins
pubmed
12145344
uniprot
proteins
pubmed
15148396
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21467038
uniprot
proteins
pubmed
23994616
uniprot
proteins
pubmed
2826231
uniprot
proteins
pubmed
3092218
uniprot
proteins
pubmed
8227063
uniprot
proteins
pubmed
9860993
uniprot
proteins
sequence_length
1133
uniprot
proteins
sequence_length
257
uniprot
proteins
sequence_length
394
uniprot
proteins
sequence_length
725
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q63803}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q63803}. Apical cell membrane {ECO:0000250|UniProtKB:Q5JWF2}. Note=Associated to the plasma membrane via lipid-anchor. {ECO:0000250|UniProtKB:Q63803}.
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8227063}; Peripheral membrane protein {ECO:0000269|PubMed:8227063}; Cytoplasmic side {ECO:0000269|PubMed:8227063}. Note=Associated to the plasma membrane via lipid-anchor. {ECO:0000269|PubMed:8227063}.
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Cell projection, ruffle {ECO:0000250}. Note=Predominantly associated with cell membrane ruffles. {ECO:0000250}.
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Secreted {ECO:0000250}. Note=Neuroendocrine secretory granules. {ECO:0000250}.
uniprot
proteins