Pex14
entrez
56273
canonical
uniprot
Q9R0A0
canonical
ensembl
ENSMUSG00000028975
resolver
ensp
ENSMUSP00000099506
resolver
enst
ENSMUST00000103217
resolver
genesymbol
Pex14
resolver
uniprot_entry
PEX14_MOUSE
resolver
amino_acid_sequence
MASSEQAEQPNQPSSPPGSENVVPREPLIATAVKFLQNSRVRQSPLATRRAFLKKKGLTDEEIDLAFQQSGTAADEPSPLGPATPVVPVQPPHLTPQPYSPRGSRWRDYGALAIIMAGIAFGFHQLYKRYLLPLILGGREDRKQLERMAASLSELSGTVAQTVTQVQTTLASVQELLRQQQQKVQELAHELATAKATTSTNWILESQNINELKSEINSLKGLLLNRRQFPPSPSAPKIPSWQIPVKSSSPSSPAAVNHHSSSDISPVSNESTSSSPGKDSHSPEGSTATYHLLGPQEEGEGVLDVKGQVRMEVQGEEEKREDKEDEDDEDDDVSHVDEEDVLGVQREDRRGGDGQINEQVEKLRRPEGASNETERD
uniprot
proteins
function
FUNCTION: Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (By similarity). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix. Plays a key role for peroxisome movement through a direct interaction with tubulin (By similarity). {ECO:0000250|UniProtKB:O75381, ECO:0000250|UniProtKB:P53112}.
uniprot
proteins
mass_dalton
41208
uniprot
proteins
protein_family
Peroxin-14 family
uniprot
proteins
pubmed
12488033
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
376
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Peroxisome membrane {ECO:0000269|PubMed:12488033}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q642G4}.
uniprot
proteins
transmembrane_region
TRANSMEM 109..127; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins