Atf5
entrez
282840
canonical
uniprot
Q6P788
canonical
ensembl
ENSRNOG00000020060
resolver
ensp
ENSRNOP00000027260
resolver
enst
ENSRNOT00000027260
resolver
genesymbol
Atf5
resolver
genesymbol_syn
Atfx
resolver
uniprot
A0A0G2JSS0
resolver
uniprot
Q8CIT6
resolver
uniprot_entry
A0A0G2JSS0_RAT
resolver
uniprot_entry
ATF5_RAT
resolver
uniprot_sec
Q8CIT6
resolver
amino_acid_sequence
MSLLATLGLELDRALLPASGLGWLVDYGKLPLAPAPLGPYEVLGGALEGGLPGGGEPLAGDGFSDWMTERVDFTALLPLEAPLPPGTLPPPSPAPPDLEAMASLLKKELEQMEDFFLDAPLLPPPSPPPPPPPAPSLPLPLPLPTFDLPQPPTLDTLDLLAVYCRSEAGPGDSGLTTLPVPQQPPPLAPLPSLSRPAPYPSPASTRGDRKQKKRDQNKSAALRYRQRKRAEGEALEGECQGLEARNRELRERAESVEREIQYVKDLLIEVYKARSQRTRSA
uniprot
proteins
function
FUNCTION: Transcription factor that either stimulates or represses gene transcription through binding of different DNA regulatory elements such as cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), ATF5-specific response element (ARE) (consensus: 5'-C[CT]TCT[CT]CCTT[AT]-3') but also the amino acid response element (AARE), present in many viral and cellular promoters. Critically involved, often in a cell type-dependent manner, in cell survival, proliferation, and differentiation. Its transcriptional activity is enhanced by CCND3 and slightly inhibited by CDK4 (By similarity) (PubMed:19531563, PubMed:21212266). Important regulator of the cerebral cortex formation, functions in cerebral cortical neuroprogenitor cells to maintain proliferation and to block differentiation into neurons. Must be down-regulated in order for such cells to exit the cycle and differentiate (By similarity) (PubMed:12805299). Participates in the pathways by which SHH promotes cerebellar granule neuron progenitor cells proliferation. Critical for survival of mature olfactory sensory neurons (OSN), directs expression of OSN-specific genes (By similarity). May be involved in osteogenic differentiation. Promotes cell proliferation and survival by inducing the expression of EGR1 sinergistically with ELK1. Once acetylated by EP300, binds to ARE sequences on target genes promoters, such as BCL2 and EGR1 (By similarity) (PubMed:21791614). Plays an anti-apoptotic role through the transcriptional regulation of BCL2, this function seems to be cell type-dependent (By similarity). Cooperates with NR1I3/CAR in the transcriptional activation of CYP2B6 in liver. In hepatic cells, represses CRE-dependent transcription and inhibits proliferation by blocking at G2/M phase. May act as a negative regulator of IL1B transduction pathway in liver. Upon IL1B stimulus, cooperates with NLK to activate the transactivation activity of C/EBP subfamily members. Besides its function of transcription factor, acts as a cofactor of CEBPB to activate CEBPA and promote adipocyte differentiation. Regulates centrosome dynamics in a cell-cycle- and centriole-age-dependent manner. Forms 9-foci symmetrical ring scaffold around the mother centriole to control centrosome function and the interaction between centrioles and pericentriolar material (By similarity). {ECO:0000250|UniProtKB:O70191, ECO:0000250|UniProtKB:Q9Y2D1, ECO:0000269|PubMed:12805299, ECO:0000269|PubMed:19531563, ECO:0000269|PubMed:21212266, ECO:0000269|PubMed:21791614}.
uniprot
proteins
mass_dalton
30205
uniprot
proteins
mutagenesis
MUTAGEN 29; /note="K->R: Not acetylated by EP300."; /evidence="ECO:0000269|PubMed:21791614
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by CDC34 and UBE2B in order to be degraded by the proteasome. {ECO:0000250}.; PTM: Acetylated at Lys-29 by EP300, the acetylation enhances the interaction with CEBPB, DNA-binding and transactivation activity. {ECO:0000269|PubMed:21791614}.; PTM: Ubiquitinated by CDC34 and UBE2B in order to be degraded by the proteasome. Cisplatin inhibits ubiquitination and proteasome-mediated degradation by inhibiting the interaction with CDC34. Ubiquitination and degradation by the proteasome are inhibited by NLK in a kinase-independent manner. {ECO:0000250|UniProtKB:Q9Y2D1}.; PTM: Phosphorylated by NLK, probably at Ser-92 and Ser-126. {ECO:0000250|UniProtKB:Q9Y2D1}.
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
pubmed
12805299
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19531563
uniprot
proteins
pubmed
21212266
uniprot
proteins
pubmed
21791614
uniprot
proteins
sequence_length
281
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9Y2D1}. Nucleus {ECO:0000250|UniProtKB:Q9Y2D1, ECO:0000255|PROSITE-ProRule:PRU00978}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9Y2D1}. Note=Actively transported to the centrosome and accumulated in the pericentriolar material (PCM) during G1 to M phase via a microtubule-dependent mechanism. During late telophase and cytokinesis, translocates from the centrosome to the midbody. {ECO:0000250|UniProtKB:Q9Y2D1}.
uniprot
proteins