PRKAG1
entrez
5571
canonical
uniprot
P54619
canonical
ensembl
ENSG00000181929
resolver
ensp
ENSP00000323867
resolver
ensp
ENSP00000447433
resolver
ensp
ENSP00000448873
resolver
ensp
ENSP00000448972
resolver
enst
ENST00000547306
resolver
genesymbol
PRKAG1
resolver
hgnc
HGNC:9385
resolver
uniprot
B4DDT7
resolver
uniprot
F8VYY9
resolver
uniprot
Q8N7V9
resolver
uniprot_entry
AAKG1_HUMAN
resolver
uniprot_entry
F8VYY9_HUMAN
resolver
uniprot_sec
B4DDT7
resolver
uniprot_sec
Q8N7V9
resolver
amino_acid_sequence
METVISSDSSPAVENEHPQETPESNNSVYTSFMKSHRCYDLIPTSSKLVVFDTSLQVKKAFFALVTNGVRAAPLWDSKKQSFVGMLTITDFINILHRYYKSALVQIYELEEHKIETWREVYLQDSFKPLVCISPNASLFDAVSSLIRNKIHRLPVIDPESGNTLYILTHKRILKFLKLFITEFPKPEFMSKSLEELQIGTYANIAMVRTTTPVYVALGIFVQHRVSALPVVDEKGRVVDIYSKFDVINLAAEKTYNNLDVSVTKALQHRSHYFEGVLKCYLHETLETIINRLVEAEVHRLVVVDENDVVKGIVSLSDILQALVLTGGEKKP
uniprot
proteins
function
FUNCTION: AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism (PubMed:21680840, PubMed:24563466). In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation (PubMed:21680840, PubMed:24563466). AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators (PubMed:21680840, PubMed:24563466). Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin (PubMed:21680840, PubMed:24563466). Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits (PubMed:21680840, PubMed:24563466). ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit (PubMed:21680840, PubMed:24563466). ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive (PubMed:21680840, PubMed:24563466). {ECO:0000269|PubMed:21680840, ECO:0000269|PubMed:24563466}.
uniprot
proteins
mass_dalton
37579
uniprot
proteins
mutagenesis
MUTAGEN 90; /note="D->A: Reduced AMP-activation of phosphorylation of PRKAA1 or PRKAA2. Reduced ADP activation of phosphorylation of PRKAA1 or PRKAA2."; /evidence="ECO:0000269|PubMed:21680840"; MUTAGEN 245; /note="D->A: Reduced AMP-activation of phosphorylation of PRKAA1 or PRKAA2. Reduced ADP activation of phosphorylation of PRKAA1 or PRKAA2."; /evidence="ECO:0000269|PubMed:21680840"; MUTAGEN 317; /note="D->A: Reduced AMP-activation of phosphorylation of PRKAA1 or PRKAA2. Does not affect ADP activation of phosphorylation of PRKAA1 or PRKAA2."; /evidence="ECO:0000269|PubMed:21680840
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by ULK1 and ULK2; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1, ULK2 and AMPK. {ECO:0000269|PubMed:21460634}.; PTM: Glycosylated; O-GlcNAcylated by OGT, promoting the AMP-activated protein kinase (AMPK) activity. {ECO:0000269|PubMed:24563466}.
uniprot
proteins
protein_family
5'-AMP-activated protein kinase gamma subunit family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14722619
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17028174
uniprot
proteins
pubmed
17255938
uniprot
proteins
pubmed
17307971
uniprot
proteins
pubmed
17452784
uniprot
proteins
pubmed
17712357
uniprot
proteins
pubmed
18403135
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21460634
uniprot
proteins
pubmed
21680840
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
24352254
uniprot
proteins
pubmed
24563466
uniprot
proteins
pubmed
25412657
uniprot
proteins
pubmed
26952388
uniprot
proteins
pubmed
8621499
uniprot
proteins
sequence_length
331
uniprot
proteins