Pum1
entrez
80912
canonical
uniprot
Q80U78
canonical
ensembl
ENSMUSG00000028580
resolver
ensp
ENSMUSP00000030315
resolver
ensp
ENSMUSP00000095474
resolver
ensp
ENSMUSP00000095476
resolver
ensp
ENSMUSP00000101612
resolver
ensp
ENSMUSP00000101613
resolver
ensp
ENSMUSP00000184824
resolver
ensp
ENSMUSP00000184826
resolver
ensp
ENSMUSP00000184829
resolver
ensp
ENSMUSP00000184832
resolver
ensp
ENSMUSP00000184833
resolver
ensp
ENSMUSP00000184835
resolver
ensp
ENSMUSP00000184840
resolver
ensp
ENSMUSP00000184841
resolver
ensp
ENSMUSP00000184848
resolver
ensp
ENSMUSP00000184851
resolver
ensp
ENSMUSP00000184853
resolver
ensp
ENSMUSP00000184855
resolver
ensp
ENSMUSP00000184860
resolver
ensp
ENSMUSP00000184861
resolver
ensp
ENSMUSP00000184862
resolver
ensp
ENSMUSP00000184863
resolver
ensp
ENSMUSP00000184868
resolver
ensp
ENSMUSP00000184870
resolver
ensp
ENSMUSP00000184874
resolver
ensp
ENSMUSP00000184875
resolver
ensp
ENSMUSP00000184876
resolver
ensp
ENSMUSP00000184878
resolver
ensp
ENSMUSP00000184881
resolver
ensp
ENSMUSP00000184884
resolver
ensp
ENSMUSP00000184889
resolver
ensp
ENSMUSP00000184891
resolver
ensp
ENSMUSP00000184895
resolver
ensp
ENSMUSP00000184899
resolver
ensp
ENSMUSP00000184905
resolver
ensp
ENSMUSP00000184913
resolver
ensp
ENSMUSP00000184915
resolver
ensp
ENSMUSP00000184923
resolver
ensp
ENSMUSP00000184932
resolver
enst
ENSMUST00000105991
resolver
enst
ENSMUST00000105992
resolver
genesymbol
Pum1
resolver
genesymbol_syn
Kiaa0099
resolver
uniprot
E9Q6M7
resolver
uniprot
F7BD19
resolver
uniprot
Q3TQ21
resolver
uniprot
Q3TTW5
resolver
uniprot
Q80X96
resolver
uniprot
Q80YU8
resolver
uniprot
Q8BPV7
resolver
uniprot
Q9EPU6
resolver
uniprot_entry
E9Q6M7_MOUSE
resolver
uniprot_entry
F7BD19_MOUSE
resolver
uniprot_entry
PUM1_MOUSE
resolver
uniprot_entry
Q3TQ21_MOUSE
resolver
uniprot_entry
Q3TTW5_MOUSE
resolver
uniprot_sec
Q80X96
resolver
uniprot_sec
Q80YU8
resolver
uniprot_sec
Q8BPV7
resolver
uniprot_sec
Q9EPU6
resolver
amino_acid_sequence
MSVACVLKRKAVLWQDSFSPHLKHHPQEPANPNMPVVLTSGTGSQAQPQPAANQALAAGTHSSPVPGSIGVAGRSQDDAMVDYFFQRQHGEQLGGGGSGGGGYNTSKHRWPTGDNIHAEHQVRSMDELNHDFQALALEGRAMGEQLLPGKKFWETDESSKDGPKGIFLGDQWRDSAWGTSDHSVSQPIMVQRRPGQSFHVNSEVNSVLSPRSESGGLGVSMVEYVLSSSPGDSCLRKGGFGPRDADSDENDKGEKKNKGTFDGDKLGDLKEEGDVMDKTNGLPVQNGIDADVKDFSRTPGNCQNSANEVDLLGPNQNGSEGLAQLTSTNGAKPVEDFSNMESQSVPLDPMEHVGMEPLQFDYSGTQVPVDSAAATVGLFDYNSQQQLFQRPNALAVQQLTAAQQQQYALAAAHQPHIAGLAPAAFVPNPYIISAAPPGTDPYTAGLAAAATLGPAVVPHQYYGVTPWGVYPASLFQQQAAAAAAATNSATQQSAPQAQQGQQQVLRGGASQRPLTPNQNQQGQQTDPLVAAAAVNSALAFGQGLAAGMPGYPVLAPAAYYDQTGALVVNAGARNGLGAPVRLVAPAPVIISSSAAQAAVAAAAASANGAAGGLAGTTNGPFRPLGTQQPQPQPQQQPSNNLASSSFYGNNSLSSNSQSSSLFSQGSAQPANTSLGFGSSSSLGATLGSALGGFGTAVANSNTGSGSRRDSLTGSSDLYKRTSSSLAPIGHSFYSSLSYSSSPGPVGMPLPSQGPGHSQTPPPSLSSHGSSSSLNLGGLTNGSGRYISAAPGAEAKYRSASSASSLFSPSSTLFSSSRLRYGMSDVMPSGRSRLLEDFRNNRYPNLQLREIAGHIMEFSQDQHGSRFIQLKLERATAAERQLVFNEILQAAYQLMVDVFGNYVIQKFFEFGSHEQKLALAERIRGHVLSLALQMYGCRVIQKALEFIPSDQQVINEMVRELDGHVLKCVKDQNGNHVVQKCIECVQPQSLQFIIDAFKGQVFALSTHPYGCRVIQRILEHCLPDQTLPILEELHQHTEQLVQDQYGNYVIQHVLEHGRPEDKSKIVAEIRGNVLVLSQHKFASNVVEKCVTHASRTERAVLIDEVCTMNDGPHSALYTMMKDQYANYVVQKMIDVAEPGQRKIVMHKIRPHIATLRKYTYGKHILAKLEKYYMKNGVDLGPICGPPNGII
uniprot
proteins
function
FUNCTION: Sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. Binds to an RNA consensus sequence, the Pumilio Response Element (PRE), 5'-UGUANAUA-3', that is related to the Nanos Response Element (NRE). Mediates post-transcriptional repression of transcripts via different mechanisms: acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Also mediates deadenylation-independent repression by promoting accessibility of miRNAs. Following growth factor stimulation, phosphorylated and binds to the 3'-UTR of CDKN1B/p27 mRNA, inducing a local conformational change that exposes miRNA-binding sites, promoting association of miR-221 and miR-222, efficient suppression of CDKN1B/p27 expression, and rapid entry to the cell cycle (By similarity). Acts as a post-transcriptional repressor of E2F3 mRNAs by binding to its 3'-UTR and facilitating miRNA regulation (By similarity). Represses a program of genes necessary to maintain genomic stability such as key mitotic, DNA repair and DNA replication factors. Its ability to repress those target mRNAs is regulated by the lncRNA NORAD (non-coding RNA activated by DNA damage) which, due to its high abundance and multitude of PUMILIO binding sites, is able to sequester a significant fraction of PUM1 and PUM2 in the cytoplasm (By similarity). Involved in neuronal functions by regulating ATXN1 mRNA levels: acts by binding to the 3'-UTR of ATXN1 transcripts, leading to their down-regulation independently of the miRNA machinery (PubMed:25768905). In testis, acts as a post-transcriptional regulator of spermatogenesis by binding to the 3'-UTR of mRNAs coding for regulators of p53/TP53 (PubMed:22342750). Involved in embryonic stem cell renewal by facilitating the exit from the ground state: acts by targeting mRNAs coding for naive pluripotency transcription factors and accelerates their down-regulation at the onset of differentiation (PubMed:24412312). Binds specifically to miRNA MIR199A precursor, with PUM2, regulates miRNA MIR199A expression at a postranscriptional level (By similarity). {ECO:0000250|UniProtKB:Q14671, ECO:0000269|PubMed:22342750, ECO:0000269|PubMed:24412312, ECO:0000269|PubMed:25768905}.
uniprot
proteins
mass_dalton
126619
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-715 promotes RNA-binding activity. Following growth factor stimulation phosphorylated at Ser-715, promoting binding to the 3'-UTR of CDKN1B/p27 mRNA. {ECO:0000250|UniProtKB:Q14671}.
uniprot
proteins
pubmed
12667987
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22342750
uniprot
proteins
pubmed
24412312
uniprot
proteins
pubmed
25768905
uniprot
proteins
pubmed
29474920
uniprot
proteins
sequence_length
1189
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:22342750}. Cytoplasm, P-body {ECO:0000250|UniProtKB:Q14671}. Cytoplasmic granule {ECO:0000250|UniProtKB:Q14671}.
uniprot
proteins