ANGEL1
entrez
23357
canonical
uniprot
Q9UNK9
canonical
ensembl
ENSG00000013523
resolver
ensp
ENSP00000251089
resolver
ensp
ENSP00000519383
resolver
ensp
ENSP00000519384
resolver
ensp
ENSP00000521386
resolver
ensp
ENSP00000689122
resolver
enst
ENST00000251089
resolver
enst
ENST00000554058
resolver
enst
ENST00000556072
resolver
genesymbol
ANGEL1
resolver
genesymbol_syn
KIAA0759
resolver
hgnc
HGNC:19961
resolver
uniprot
B4DWL7
resolver
uniprot
O94859
resolver
uniprot
Q8NCS9
resolver
uniprot_entry
ANGE1_HUMAN
resolver
uniprot_sec
B4DWL7
resolver
uniprot_sec
O94859
resolver
uniprot_sec
Q8NCS9
resolver
amino_acid_sequence
MIASCLCYLLLPATRLFRALSDAFFTCRKNVLLANSSSPQVEGDFAMAPRGPEQEECEGLLQQWREEGLSQVLSTASEGPLIDKGLAQSSLALLMDNPGEENAASEDRWSSRQLSDLRAAENLDEPFPEMLGEEPLLEVEGVEGSMWAAIPMQSEPQYADCAALPVGALATEQWEEDPAVLAWSIAPEPVPQEEASIWPFEGLGQLQPPAVEIPYHEILWREWEDFSTQPDAQGLKAGDGPQFQFTLMSYNILAQDLMQQSSELYLHCHPDILNWNYRFVNLMQEFQHWDPDILCLQEVQEDHYWEQLEPSLRMMGFTCFYKRRTGCKTDGCAVCYKPTRFRLLCASPVEYFRPGLELLNRDNVGLVLLLQPLVPEGLGQVSVAPLCVANTHILYNPRRGDVKLAQMAILLAEVDKVARLSDGSHCPIILCGDLNSVPDSPLYNFIRDGELQYHGMPAWKVSGQEDFSHQLYQRKLQAPLWPSSLGITDCCQYVTSCHPKRSERRKYGRDFLLRFRFCSIACQRPVGLVLMEGVTDTKPERPAGWAESVLEEDASELEPAFSRTVGTIQHCLHLTSVYTHFLPQRGRPEVTTMPLGLGMTVDYIFFSAESCENGNRTDHRLYRDGTLKLLGRLSLLSEEILWAANGLPNPFCSSDHLCLLASFGMEVTAP
uniprot
proteins
ec_number
3.-.-.-
uniprot
proteins
function
FUNCTION: Exhibits weak RNA 2',3'-cyclic phosphatase, catalyzing the hydrolysis of RNA molecules with a 2',3'-cyclic phosphate at the 3' end to produce RNA with a linear 3'-phosphate group (PubMed:32732418). Plays a role in the non-stop mRNA decay pathway (NSD), which specifically targets and degrades mRNAs that lack a proper stop codon (PubMed:40441874). {ECO:0000269|PubMed:32732418, ECO:0000269|PubMed:40441874}.
uniprot
proteins
mass_dalton
75276
uniprot
proteins
mutagenesis
MUTAGEN 298; /note="E->A: Disrupts function in non-stop mRNA decay."; /evidence="ECO:0000269|PubMed:40441874"; MUTAGEN 507; /note="Y->A: Loss of interaction with EIF4E."; /evidence="ECO:0000269|PubMed:23814182
uniprot
proteins
protein_family
CCR4/nocturin family
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23814182
uniprot
proteins
pubmed
32732418
uniprot
proteins
pubmed
36180430
uniprot
proteins
pubmed
40441874
uniprot
proteins
pubmed
9872452
uniprot
proteins
sequence_length
670
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000269|PubMed:36180430}. Golgi apparatus {ECO:0000269|PubMed:23814182}. Endoplasmic reticulum {ECO:0000269|PubMed:23814182}.
uniprot
proteins