Scn11a
entrez
24046
canonical
uniprot
Q9R053
canonical
ensembl
ENSMUSG00000034115
resolver
ensp
ENSMUSP00000065466
resolver
ensp
ENSMUSP00000149420
resolver
enst
ENSMUST00000070617
resolver
enst
ENSMUST00000215718
resolver
genesymbol
Scn11a
resolver
genesymbol_syn
Nan
resolver
genesymbol_syn
Nat
resolver
genesymbol_syn
Sns2
resolver
uniprot
E9QM88
resolver
uniprot
Q9JMD4
resolver
uniprot_entry
SCNBA_MOUSE
resolver
uniprot_sec
E9QM88
resolver
uniprot_sec
Q9JMD4
resolver
amino_acid_sequence
MEERYYPVIFPDERNFRPFTFDSLAAIEKRITIQKEKKKSKDKAATEPQPRPQLDLKASRKLPKLYGDVPPDLIAKPLEDLDPFYKDHKTFMVLNKKRTIYRFSAKRALFILGPFNPIRSFMIRISVHSVFSMFIICTVIINCMFMANNSSVDSRPSSNIPEYVFIGIYVLEAVIKILARGFIVDEFSYLRDPWNWLDFIVIGTAIAPCFLGNKVNNLSTLRTFRVLRALKAISVISGLKVIVGALLRSVKKLVDVMVLTLFCLSIFALVGQQLFMGILSQKCIKDDCGPNAFSNKDCFVKENDSEDFIMCGNWLGRRSCPDGSTCNKTTFNPDYNYTNFDSFGWSFLAMFRVMTQDSWEKLYRQILRTSGIYFVFFFVVVIFLGSFYLLNLTLAVVTMAYEEQNRNVAAETEAKEKMFQEAQQLLREEKEALVAMGIDRTSLNSLQASSFSPKKRKFFGSKTRKSFFMRGSKTARASASDSEDDASKNPQLLEQTKRLSQNLPVELFDEHVDPLHRQRALSAVSILTITMQEQEKSQEPCFPCGKNLASKYLVWECSPPWLCIKKVLQTIMTDPFTELAITICIIVNTVFLAMEHHNMDNSLKDILKIGNWVFTGIFIAEMCLKIIALDPYHYFRHGWNIFDSIVALVSLADVLFHKLSKNLSFLASLRVLRVFKLAKSWPTLNTLIKIIGHSVGALGNLTVVLTIVVFIFSVVGMRLFGAKFNKTCSTSPESLRRWHMGDFYHSFLVVFRILCGEWIENMWECMQEMEGSPLCVIVFVLIMVVGKLVVLNLFIALLLNSFSNEEKDGNPEGETRKTKVQLALDRFSRAFYFMARALQNFCCKRCRRQNSPKPNEATESFAGESRDTATLDTRSWKEYDSEMTLYTGQAGAPLAPLAKEEDDMECCGECDASPTSQPSEEAQACDLPLKTKRLPSPDDHGVEMEVFSEEDPNLTIQSARKKSDAASMLSECSTIDLNDIFRNLQKTVSPQKQPDRCFPKGLSCIFLCCKTIKKKSPWVLWWNLRKTCYQIVKHSWFESFIIFVILLSSGALIFEDVNLPSRPQVEKLLKCTDNIFTFIFLLEMILKWVAFGFRKYFTSAWCWLDFLIVVVSGLSLTNLPNLKSFRNLRALRPLRALSQFEGMKVVVNALMSAIPAILNVLLVCLIFWLIFCILGVNFFSGKFGRCINGTDINKYFNASNVPNQSQCLVSNYTWKVPNVNFDNVGNAYLALLQVATYKGWLDIMNAAVDSRGKDEQPAFEANLYAYLYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQKKYYNAMKKLGTKKPQKPIPRPLNKCQAFVFDLVTSQVFDVIILGLIVTNMIIMMAESEGQPNEVKKIFDILNIVFVVIFTVECLIKVFALRQHYFTNGWNLFDCVVVVLSIISTLVSGLENSNVFPPTLFRIVRLARIGRILRLVRAARGIRTLLFALMMSLPSLFNIGLLLFLVMFIYAIFGMNWFSKVKRGSGIDDIFNFDTFSGSMLCLFQITTSAGWDALLNPMLESKASCNSSSQESCQQPQIAIVYFVSYIIISFLIVVNMYIAVILENFNTATEESEDPLGEDDFEIFYEIWEKFDPEATQFIQYSSLSDFADALPEPLRVAKPNRFQFLMMDLPMVMGDRLHCMDVLFAFTTRVLGNSSGLDTMKAMMEEKFMEANPFKKLYEPIVTTTKRKEEEECAAVIQRAYRRHMEKMIKLKLKGRSSSSLQVFCNGDLSSLDVPKIKVHCD
uniprot
proteins
function
FUNCTION: Sodium channel mediating the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient (PubMed:24036948). Involved in membrane depolarization during action potential in nociceptors which function as key relay stations for the electrical transmission of pain signals from the periphery to the central nervous system (PubMed:24036948). Also involved in rapid BDNF-evoked neuronal depolarization (By similarity). {ECO:0000250|UniProtKB:Q9UI33, ECO:0000269|PubMed:24036948}.
uniprot
proteins
mass_dalton
201385
uniprot
proteins
mutagenesis
MUTAGEN 799; /note="L->P: Increased voltage-gated sodium channel activity."; /evidence="ECO:0000269|PubMed:24036948
uniprot
proteins
protein_family
Nav1.9/SCN11A subfamily
uniprot
proteins
protein_family
Sodium channel (TC 1.A.1.10) family
uniprot
proteins
pubmed
10444332
uniprot
proteins
pubmed
10623609
uniprot
proteins
pubmed
14515348
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
24036948
uniprot
proteins
sequence_length
1765
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:24036948}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 127..148; /note="Helical; Name=S1 of repeat I"; /evidence="ECO:0000250"; TRANSMEM 160..179; /note="Helical; Name=S2 of repeat I"; /evidence="ECO:0000250"; TRANSMEM 192..211; /note="Helical; Name=S3 of repeat I"; /evidence="ECO:0000250"; TRANSMEM 220..239; /note="Helical; Voltage-sensor; Name=S4 of repeat I"; /evidence="ECO:0000250"; TRANSMEM 256..269; /note="Helical; Name=S5 of repeat I"; /evidence="ECO:0000250"; TRANSMEM 375..400; /note="Helical; Name=S6 of repeat I"; /evidence="ECO:0000250"; TRANSMEM 571..594; /note="Helical; Name=S1 of repeat II"; /evidence="ECO:0000250"; TRANSMEM 606..629; /note="Helical; Name=S2 of repeat II"; /evidence="ECO:0000250"; TRANSMEM 638..659; /note="Helical; Name=S3 of repeat II"; /evidence="ECO:0000250"; TRANSMEM 665..684; /note="Helical; Voltage-sensor; Name=S4 of repeat II"; /evidence="ECO:0000250"; TRANSMEM 700..722; /note="Helical; Name=S5 of repeat II"; /evidence="ECO:0000250"; TRANSMEM 774..799; /note="Helical; Name=S6 of repeat II"; /evidence="ECO:0000250"; TRANSMEM 1031..1053; /note="Helical; Name=S1 of repeat III"; /evidence="ECO:0000250"; TRANSMEM 1068..1093; /note="Helical; Name=S2 of repeat III"; /evidence="ECO:0000250"; TRANSMEM 1100..1117; /note="Helical; Name=S3 of repeat III"; /evidence="ECO:0000250"; TRANSMEM 1119..1140; /note="Helical; Voltage-sensor; Name=S4 of repeat III"; /evidence="ECO:0000250"; TRANSMEM 1160..1181; /note="Helical; Name=S5 of repeat III"; /evidence="ECO:0000250"; TRANSMEM 1263..1289; /note="Helical; Name=S6 of repeat III"; /evidence="ECO:0000250"; TRANSMEM 1343..1366; /note="Helical; Name=S1 of repeat IV"; /evidence="ECO:0000250"; TRANSMEM 1378..1401; /note="Helical; Name=S2 of repeat IV"; /evidence="ECO:0000250"; TRANSMEM 1408..1431; /note="Helical; Name=S3 of repeat IV"; /evidence="ECO:0000250"; TRANSMEM 1441..1463; /note="Helical; Voltage-sensor; Name=S4 of repeat IV"; /evidence="ECO:0000250"; TRANSMEM 1479..1501; /note="Helical; Name=S5 of repeat IV"; /evidence="ECO:0000250"; TRANSMEM 1560..1584; /note="Helical; Name=S6 of repeat IV"; /evidence="ECO:0000250
uniprot
proteins