Klk7
entrez
23993
canonical
uniprot
Q91VE3
canonical
ensembl
ENSMUSG00000030713
resolver
ensp
ENSMUSP00000032955
resolver
enst
ENSMUST00000032955
resolver
genesymbol
Klk7
resolver
genesymbol_syn
Prss6
resolver
genesymbol_syn
Scce
resolver
uniprot
A0A0B6VPC4
resolver
uniprot
Q9R048
resolver
uniprot_entry
A0A0B6VPC4_MOUSE
resolver
uniprot_entry
KLK7_MOUSE
resolver
uniprot_sec
Q9R048
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by Zn2+ and Cu2+ at low micromolar concentrations. Inhibited by SERPINA12 (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MGVWLLSLITVLLSLALETAGQGERIIDGYKCKEGSHPWQVALLKGNQLHCGGVLVDKYWVLTAAHCKMGQYQVQLGSDKIGDQSAQKIKATKSFRHPGYSTKTHVNDIMLVRLDEPVKMSSKVEAVQLPEHCEPPGTSCTVSGWGTTTSPDVTFPSDLMCSDVKLISSRECKKVYKDLLGKTMLCAGIPDSKTNTCNGDSGGPLVCNDTLQGLVSWGTYPCGQPNDPGVYTQVCKYKRWVMETMKTHR
uniprot
proteins
ec_number
3.4.21.117
uniprot
proteins
function
FUNCTION: May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines.
uniprot
proteins
mass_dalton
27257
uniprot
proteins
protein_family
Kallikrein subfamily
uniprot
proteins
protein_family
Peptidase S1 family
uniprot
proteins
pubmed
10469296
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
249
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
uniprot
proteins