Arhgap31
entrez
12549
canonical
uniprot
A6X8Z5
canonical
ensembl
ENSMUSG00000022799
resolver
ensp
ENSMUSP00000023487
resolver
enst
ENSMUST00000023487
resolver
genesymbol
Arhgap31
resolver
genesymbol_syn
Cdgap
resolver
genesymbol_syn
Kiaa1204
resolver
uniprot
B2RSI0
resolver
uniprot
Q3TL91
resolver
uniprot
Q3U1T7
resolver
uniprot
Q3UDE7
resolver
uniprot
Q3UUH4
resolver
uniprot
Q6ZPW0
resolver
uniprot
Q9WV94
resolver
uniprot_entry
B2RSI0_MOUSE
resolver
uniprot_entry
RHG31_MOUSE
resolver
uniprot_sec
Q3TL91
resolver
uniprot_sec
Q3U1T7
resolver
uniprot_sec
Q3UDE7
resolver
uniprot_sec
Q3UUH4
resolver
uniprot_sec
Q6ZPW0
resolver
uniprot_sec
Q9WV94
resolver
amino_acid_sequence
MKNKGAKQKLKRKGAASAFGCDLTEYLESSGQDVPYVLKSCAEFIETHGIVDGIYRLSGITSNIQRLRQEFGSDQCPDLTREVYLQDIHCVGSLCKLYFRELPNPLLTYELYEKFTEAVSHRPEEGQLARIQNVILELPPPHYRTLEYLIRHLAHIASFSSKTNMHARNLALVWAPNLLRSKKIEATICNGDAAFLAVRVQQVVIEFILNHADQIFNGGAPGALQQDESRTITKSLTLPALSLPMKLVSLEEAQARSLATNHPARKERRENSLPEIVPPPFHTVLELPDNKRKLSSKSKKWKSIFNLGRSGSDSKSKLSRNGSVFVRGQRLSVEKATIRPAKSMDSLCSVPVEGKENKGNFSRTVTTGGFFIPATKMHASSTGSSCDLSKEGEWGQEGMPAGAEGGCEVGGQIRPLPEQLKVFRPIGDPESEQSAPKLLGMFYTSSDSPGKSVFTSSLFQMEPSPRHQRKALNISEPFAVSVPLRVSAVISTNSTPCRTPPKELQSLSSLEEFSFQGSESGGWPEEEKPLGAESFPGSVTKKAATEDTKPEPEVPGRAECSQSPPLDPGTQVEKKTLHVSLGSQVSKEAEKRPKAEKVMEESQGASQPKPSTPQESLGAGTEPLILHEMDEEDLAQALIWPEIQQELKIIESEEEFSSLPPAAQKTSPIPESSPAPFPFPEAPGSLPSSSAPREVWTRDAANQSIQEAAILTDREKLEPVCSLLESESQQELSPDPASLAPLEMLLFEKVSSPARIEIGGPRNLSPPLTPAPPPPTPLEEEPEVLLSKEGPDREDAARDSRTDVYTEQPTPKESPGIPTPCQREEAIASPNEKQNARHAVPENKGPGLPSPTKEVDIIPQEEGGAPHSAQEPSDCDEDDTVTDPAQHGLEMVEPWEEPQWVTSPLHSPTLKEVQESQTQGSQGHRLERRLCHRPSLRQSHSLDSKTTGNSHWTLEAPFSSSCANLETERNYEPLQPPAARTKIAGLEEKALKAFREFSGLKGLEVLPSQKGPSGIQPKPVETNFMGLAEGKEQEPQLELSNRQMKHSDVPGPDSSKESSPRAQDSTLPGEHPLQLQLKNTECGPSKGKHRPSSLNLDSATPIADLFRLENGAPFSSPGIELSELGDTKVTWMSSSHCKAAPWNSQDTQDLDIVAHTLTGRRNSAPVSVSAVRTSFMVKMCQAKAVPVIPPKIQYTQIPQPLPSQSTGEGGAQPLERSQEEPGSTPEIPQKSTKDDSPSSLGSPEEEQPKQETGASASRRQASITSCMYEGSSCSPEPSASTLASTQDAVVQCRKRTSETEPSGDNLLSSKLERASGGPKAFHRSRPGRPQSLILFPIMDHLPSSPTVIDSKVLLSPIRSPTQTVSPGLLCGELAENTWITPEGVTLRNKMTIPKNGQRLETSTSCFYQPQRRSVILDGRSGRQIE
uniprot
proteins
function
FUNCTION: Functions as a GTPase-activating protein (GAP) for RAC1 and CDC42. Required for cell spreading, polarized lamellipodia formation and cell migration. {ECO:0000269|PubMed:16860736, ECO:0000269|PubMed:9786927}.
uniprot
proteins
mass_dalton
155276
uniprot
proteins
mutagenesis
MUTAGEN 56; /note="R->A: 70% reduction of GAP activity; when associated with V-169."; /evidence="ECO:0000269|PubMed:16860736"; MUTAGEN 169; /note="N->V: 70% reduction of GAP activity; when associated with A-56."; /evidence="ECO:0000269|PubMed:16860736
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Thr-776 by GSK3; which reduces GAP activity. {ECO:0000269|PubMed:16024771, ECO:0000269|PubMed:17158447}.
uniprot
proteins
pubmed
11744688
uniprot
proteins
pubmed
14621295
uniprot
proteins
pubmed
16024771
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16860736
uniprot
proteins
pubmed
17158447
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
9786927
uniprot
proteins
sequence_length
1425
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, lamellipodium. Cell junction, focal adhesion.
uniprot
proteins