Cavin4
entrez
313225
canonical
uniprot
B1PRL5
canonical
ensembl
ENSRNOG00000008027
resolver
ensembl
ENSRNOG00055020963
resolver
ensembl
ENSRNOG00060005263
resolver
ensembl
ENSRNOG00065010763
resolver
ensp
ENSRNOP00000010561
resolver
ensp
ENSRNOP00055029051
resolver
ensp
ENSRNOP00060006594
resolver
ensp
ENSRNOP00065013356
resolver
enst
ENSRNOT00000010561
resolver
enst
ENSRNOT00055035794
resolver
enst
ENSRNOT00060008748
resolver
enst
ENSRNOT00065017421
resolver
genesymbol
Cavin4
resolver
genesymbol_syn
Murc
resolver
uniprot_entry
CAVN4_RAT
resolver
amino_acid_sequence
MEHNGSASNAGKIHQNRLSSVTEDEDQDAALTIVTVLDRVATVVDSVQASQKRIEERHREMGNAIKSVQIDLLKLSQSHSNTGYVVNKLFEKTRKVSAHIKDVKARVEKQQVRVTKVETKQEEIMKKNKFRVVIFQEDVPCPASLSVVKDRSLPENEEEAEEVFDPPIDLSSDEEYYVEESRSARLRKSGKEHIDHIKKAFSKENMQKTRQNFDKKVSGIRTRIVTPERRERLRQSGERLRQSGERLRQSGERFKKSISNATPSKEAFKIRSLRKPKDPKAEGQEVDRGMGVDIISGSLALGPIHEFHSDGFSETEKEVTKVGYIPQEGGDPPTPEPLKVTFKPQVRVEDDESLLLELKQSS
uniprot
proteins
function
FUNCTION: Modulates the morphology of formed caveolae in cardiomyocytes, but is not required for caveolar formation. Facilitates the recruitment of MAPK1/3 to caveolae within cardiomyocytes and regulates alpha-1 adrenergic receptor-induced hypertrophic responses in cardiomyocytes through MAPK1/3 activation. Contributes to proper membrane localization and stabilization of caveolin-3 (CAV3) in cardiomyocytes (By similarity). Induces RHOA activation and activates NPPA transcription and myofibrillar organization through the Rho/ROCK signaling pathway (PubMed:18332105). {ECO:0000250|UniProtKB:A2AMM0, ECO:0000269|PubMed:18332105}.
uniprot
proteins
mass_dalton
41093
uniprot
proteins
protein_family
CAVIN family
uniprot
proteins
pubmed
18332105
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
24567387
uniprot
proteins
sequence_length
362
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere {ECO:0000250|UniProtKB:A2AMM0}. Cytoplasm {ECO:0000250|UniProtKB:A2AMM0}. Cytoplasm, cytosol {ECO:0000250|UniProtKB:A2AMM0}. Cell membrane, sarcolemma {ECO:0000250|UniProtKB:A2AMM0}. Membrane, caveola {ECO:0000269|PubMed:24567387}. Cell membrane {ECO:0000250|UniProtKB:A2AMM0}. Note=In cardiomyocytes, accumulates in the Z-line of the sarcomere. In vascular smooth muscle cells, detected diffusely throughout the cytoplasm. Localizes in the caveolae in a caveolin-dependent manner. {ECO:0000250|UniProtKB:A2AMM0}.
uniprot
proteins