ABHD17B
entrez
51104
canonical
uniprot
Q5VST6
canonical
ensembl
ENSG00000107362
resolver
ensp
ENSP00000330222
resolver
ensp
ENSP00000366240
resolver
ensp
ENSP00000530649
resolver
ensp
ENSP00000530657
resolver
genesymbol
ABHD17B
resolver
genesymbol_syn
C9orf77
resolver
genesymbol_syn
FAM108B1
resolver
hgnc
HGNC:24278
resolver
uniprot
A0A384MEH9
resolver
uniprot
A8KAJ5
resolver
uniprot
Q5VST7
resolver
uniprot
Q86YB6
resolver
uniprot
Q8IY03
resolver
uniprot
Q9Y377
resolver
uniprot_entry
A0A384MEH9_HUMAN
resolver
uniprot_entry
AB17B_HUMAN
resolver
uniprot_sec
A8KAJ5
resolver
uniprot_sec
Q5VST7
resolver
uniprot_sec
Q86YB6
resolver
uniprot_sec
Q8IY03
resolver
uniprot_sec
Q9Y377
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by palmostatin-B. {ECO:0000269|PubMed:26701913}.
uniprot
proteins
amino_acid_sequence
MNNLSFSELCCLFCCPPCPGKIASKLAFLPPDPTYTLMCDESGSRWTLHLSERADWQYSSREKDAIECFMTRTSKGNRIACMFVRCSPNAKYTLLFSHGNAVDLGQMSSFYIGLGSRINCNIFSYDYSGYGASSGKPTEKNLYADIEAAWLALRTRYGIRPENVIIYGQSIGTVPSVDLAARYESAAVILHSPLTSGMRVAFPDTKKTYCFDAFPNIDKISKITSPVLIIHGTEDEVIDFSHGLALFERCQRPVEPLWVEGAGHNDVELYGQYLERLKQFVSQELVNL
uniprot
proteins
ec_number
3.1.2.22
uniprot
proteins
function
FUNCTION: Hydrolyzes fatty acids from S-acylated cysteine residues in proteins (PubMed:26701913). Has depalmitoylating activity towards DLG4/PSD95 (PubMed:26701913). Has depalmitoylating activity towards GAP43 (By similarity). Has depalmitoylating activity towards MAP6 (By similarity). Has depalmitoylating activity towards NRAS (PubMed:26701913). {ECO:0000250|UniProtKB:Q7M759, ECO:0000269|PubMed:26701913}.
uniprot
proteins
mass_dalton
32215
uniprot
proteins
post_translational_modification
PTM: Palmitoylated on cysteine residues located in a cysteine cluster at the N-terminus which promotes membrane localization. Palmitoylation is required for post-synaptic localization and for depalmitoylating activity towards DLG4/PSD95. {ECO:0000250|UniProtKB:Q7M759}.
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
protein_family
ABHD17 family
uniprot
proteins
pubmed
10810093
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
26701913
uniprot
proteins
sequence_length
288
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q7M759}; Lipid-anchor {ECO:0000250|UniProtKB:Q7M759}; Cytoplasmic side {ECO:0000250|UniProtKB:Q7M759}. Recycling endosome membrane {ECO:0000250|UniProtKB:Q7M759}; Lipid-anchor {ECO:0000250|UniProtKB:Q7M759}; Cytoplasmic side {ECO:0000250|UniProtKB:Q7M759}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q7M759}. Postsynaptic density membrane {ECO:0000250|UniProtKB:Q7M759}.
uniprot
proteins