Fzd5
entrez
14367
canonical
uniprot
Q9EQD0
canonical
ensembl
ENSMUSG00000045005
resolver
ensp
ENSMUSP00000067783
resolver
ensp
ENSMUSP00000111828
resolver
enst
ENSMUST00000063982
resolver
enst
ENSMUST00000116133
resolver
genesymbol
Fzd5
resolver
genesymbol_syn
AI427138
resolver
uniprot
G5E8F0
resolver
uniprot
O08975
resolver
uniprot
Q3UEG1
resolver
uniprot
Q8BMR2
resolver
uniprot
Q8CHK9
resolver
uniprot_entry
FZD5_MOUSE
resolver
uniprot_entry
Q3UEG1_MOUSE
resolver
uniprot_sec
G5E8F0
resolver
uniprot_sec
O08975
resolver
uniprot_sec
Q8BMR2
resolver
uniprot_sec
Q8CHK9
resolver
amino_acid_sequence
MARPDPSAPPSLLLLLLAQLVGRAAAASKAPVCQEITVPMCRGIGYNLTHMPNQFNHDTQDEAGLEVHQFWPLVEIHCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAGCSPLMRQYGFAWPERMSCDRLPVLGGDAEVLCMDYNRSEATTASPKSFPAKPTLPGPPGAPSSGGECPSGGPSVCTCREPFVPILKESHPLYNKVRTGQVPNCAVPCYQPSFSPDERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACYLCVSLGFLVRLVVGHASVACSREHSHIHYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGNQNLNSLRGFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFTLLYTVPASIVVACYLYEQHYRESWEAALTCACPGPDAGQPRAKPEYWVLMLKYFMCLVVGITSGVWIWSGKTLESWRRFTSRCCCSSRRGHKSGGAMAAGDYAEASAALTGRTGPPGPTAAYHKQVSLSHV
uniprot
proteins
function
FUNCTION: Receptor for Wnt proteins (PubMed:11092808, PubMed:18230341). Functions in the canonical Wnt/beta-catenin signaling pathway (PubMed:18230341). In vitro activates WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 signaling (PubMed:11092808). In neurons, activation by WNT7A promotes formation of synapses (By similarity). May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). Plays a role in yolk sac angiogenesis and in placental vascularization (PubMed:11092808). Plays a role in ocular development (By similarity). {ECO:0000250|UniProtKB:Q13467, ECO:0000269|PubMed:11092808, ECO:0000269|PubMed:18230341}.
uniprot
proteins
mass_dalton
64138
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by RNF43 and ZNRF3, leading to its degradation by the proteasome. {ECO:0000250|UniProtKB:Q13467}.
uniprot
proteins
protein_family
G protein-coupled receptor Fz/Smo family
uniprot
proteins
pubmed
11092808
uniprot
proteins
pubmed
11520064
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18230341
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20530549
uniprot
proteins
pubmed
38696577
uniprot
proteins
pubmed
8626800
uniprot
proteins
sequence_length
585
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11520064, ECO:0000269|PubMed:20530549}; Multi-pass membrane protein {ECO:0000305}. Golgi apparatus membrane {ECO:0000269|PubMed:11520064}; Multi-pass membrane protein {ECO:0000305}. Synapse {ECO:0000269|PubMed:20530549}. Perikaryon {ECO:0000250|UniProtKB:Q8CHL0}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q8CHL0}. Cell projection, axon {ECO:0000250|UniProtKB:Q8CHL0}. Note=Localized at the plasma membrane and also found at the Golgi apparatus. {ECO:0000269|PubMed:11520064}.
uniprot
proteins
transmembrane_region
TRANSMEM 239..259; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 271..291; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 316..336; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 359..379; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 403..423; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 450..470; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 501..521; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins