PCBD2
entrez
84105
canonical
uniprot
Q9H0N5
canonical
ensembl
ENSG00000132570
resolver
ensp
ENSP00000254908
resolver
ensp
ENSP00000421544
resolver
enst
ENST00000254908
resolver
enst
ENST00000512783
resolver
genesymbol
PCBD2
resolver
genesymbol_syn
DCOH2
resolver
genesymbol_syn
DCOHM
resolver
hgnc
HGNC:24474
resolver
uniprot
Q8TD40
resolver
uniprot_entry
PHS2_HUMAN
resolver
uniprot_sec
Q8TD40
resolver
amino_acid_sequence
MAAVLGALGATRRLLAALRGQSLGLAAMSSGTHRLTAEERNQAILDLKAAGWSELSERDAIYKEFSFHNFNQAFGFMSRVALQAEKMNHHPEWFNVYNKVQITLTSHDCGELTKKDVKLAKFIEKAAASV
uniprot
proteins
ec_number
4.2.1.96
uniprot
proteins
function
FUNCTION: Plays a role in tetrahydrobiopterin biosynthesis which is a cofactor for amino acid hydroxylases. May prevent both the formation of 7-pterins and accelerate the formation of quinonoid-BH2 (By similarity). Regulates the dimerization of homeodomain protein HNF1A and enhances its transcriptional activity (PubMed:11980910). Also acts as a coactivator for HNF1B-dependent transcription (PubMed:33749890). {ECO:0000250|UniProtKB:Q9CZL5, ECO:0000269|PubMed:11980910, ECO:0000269|PubMed:33749890}.
uniprot
proteins
mass_dalton
14365
uniprot
proteins
mutagenesis
MUTAGEN 78; /note="S->T: About 25% loss of HNF1B promoter activity."; /evidence="ECO:0000269|PubMed:33749890
uniprot
proteins
post_translational_modification
PTM: Acetylated at Lys-118 and Lys-125. Deacetylated by SIRT1, leading to stimulation of HNF1A transcriptional activity. {ECO:0000250|UniProtKB:Q9CZL5}.
uniprot
proteins
protein_family
Pterin-4-alpha-carbinolamine dehydratase family
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
11980910
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
33749890
uniprot
proteins
sequence_length
130
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:33749890}. Cytoplasm {ECO:0000250|UniProtKB:Q9CZL5}.
uniprot
proteins