Gale
entrez
74246
canonical
uniprot
Q8R059
canonical
ensembl
ENSMUSG00000028671
resolver
ensp
ENSMUSP00000099599
resolver
ensp
ENSMUSP00000099600
resolver
ensp
ENSMUSP00000248873
resolver
enst
ENSMUST00000102540
resolver
enst
ENSMUST00000102541
resolver
genesymbol
Gale
resolver
uniprot_entry
GALE_MOUSE
resolver
amino_acid_sequence
MEKVLVTGGAGYIGSHTVLELLEAGYSPVVIDNFHNAIRGEDSMPESLRRVQELTGRSVEFEEMDILDQAALQHLFKKHSFKAVIHFAGLKAVGESVQKPLDYYRVNLTGTIQLLEIMRAHGVKNLVFSSSATVYGNPQYLPLDEAHPTGGCTNPYGKSKFFIEEMIRDLCRADTAWNAVLLRYFNPIGAHASGRIGEDPQGIPNNLMPYVSQVAIGRREALNVFGDDYATEDGTGVRDYIHVVDLAKGHIAALKKLKEQCGCRTYNLGTGTGYSVLQMVQAMEKASGKKIPYKVVARREGDVAACYANPSLAHEELGWTAALGLDRMCEDLWRWQKQNPSGFGAQA
uniprot
proteins
ec_number
5.1.3.2
uniprot
proteins
ec_number
5.1.3.7
uniprot
proteins
function
FUNCTION: Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids. {ECO:0000250|UniProtKB:Q14376}.
uniprot
proteins
mass_dalton
38225
uniprot
proteins
pathway_participation
PATHWAY: Carbohydrate metabolism; galactose metabolism.
uniprot
proteins
protein_family
NAD(P)-dependent epimerase/dehydratase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
347
uniprot
proteins