Ca2
entrez
12349
canonical
uniprot
P00920
canonical
ensembl
ENSMUSG00000027562
resolver
ensp
ENSMUSP00000029078
resolver
enst
ENSMUST00000029078
resolver
genesymbol
Ca2
resolver
genesymbol_syn
Car2
resolver
uniprot
Q6LDQ7
resolver
uniprot
Q7TPE1
resolver
uniprot
Q9DCT3
resolver
uniprot
Q9DCY9
resolver
uniprot_entry
CAH2_MOUSE
resolver
uniprot_sec
Q6LDQ7
resolver
uniprot_sec
Q7TPE1
resolver
uniprot_sec
Q9DCT3
resolver
uniprot_sec
Q9DCY9
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by acetazolamide. {ECO:0000250|UniProtKB:P00918}.
uniprot
proteins
amino_acid_sequence
MSHHWGYSKHNGPENWHKDFPIANGDRQSPVDIDTATAQHDPALQPLLISYDKAASKSIVNNGHSFNVEFDDSQDNAVLKGGPLSDSYRLIQFHFHWGSSDGQGSEHTVNKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKIGPASQGLQKVLEALHSIKTKGKRAAFANFDPCSLLPGNLDYWTYPGSLTTPPLLECVTWIVLREPITVSSEQMSHFRTLNFNEEGDAEEAMVDNWRPAQPLKNRKIKASFK
uniprot
proteins
ec_number
4.2.1.1
uniprot
proteins
ec_number
4.2.1.69
uniprot
proteins
function
FUNCTION: Catalyzes the reversible hydration of carbon dioxide (By similarity). Can also hydrate cyanamide to urea (By similarity). Involved in the regulation of fluid secretion into the anterior chamber of the eye (By similarity). Essential for bone resorption and osteoclast differentiation (By similarity). Contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption (By similarity). Stimulates the chloride-bicarbonate exchange activity of SLC26A6 (By similarity). {ECO:0000250|UniProtKB:P00918}.
uniprot
proteins
mass_dalton
29033
uniprot
proteins
protein_family
Alpha-carbonic anhydrase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20150244
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2995362
uniprot
proteins
pubmed
3000449
uniprot
proteins
pubmed
6187736
uniprot
proteins
pubmed
6331255
uniprot
proteins
pubmed
6420240
uniprot
proteins
sequence_length
260
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P00918}. Cell membrane {ECO:0000250|UniProtKB:P00918}. Note=Colocalized with SLC26A6 at the surface of the cell membrane in order to form a bicarbonate transport metabolon. Displaced from the cytosolic surface of the cell membrane by PKC in phorbol myristate acetate (PMA)-induced cells. {ECO:0000250|UniProtKB:P00918}.
uniprot
proteins