Slc25a13
entrez
362322
canonical
uniprot
F1LZW6
canonical
ensembl
ENSRNOG00000009957
resolver
ensembl
ENSRNOG00055001695
resolver
ensembl
ENSRNOG00060019003
resolver
ensembl
ENSRNOG00065010701
resolver
ensp
ENSRNOP00000076742
resolver
ensp
ENSRNOP00000107914
resolver
ensp
ENSRNOP00055002060
resolver
ensp
ENSRNOP00060027156
resolver
ensp
ENSRNOP00065013310
resolver
enst
ENSRNOT00000115980
resolver
enst
ENSRNOT00055002740
resolver
enst
ENSRNOT00060033181
resolver
enst
ENSRNOT00065017366
resolver
genesymbol
Slc25a13
resolver
genesymbol_syn
Agc2
resolver
uniprot
A0A8I5ZK53
resolver
uniprot_entry
A0A8I5ZK53_RAT
resolver
uniprot_entry
S2513_RAT
resolver
activity_regulation
ACTIVITY REGULATION: L-aspartate and 3-sulfino-L-alanine uptake are both inhibited by glisoxepide. {ECO:0000269|PubMed:486467}.
uniprot
proteins
amino_acid_sequence
MAAAKVALTKRADPAELKAIFLKYASIEKNGEFFMSPHDFVTRYLNIFGESQPNPKTVELLSGVVDQTKDGLISFQEFVAFESVLCAPDALFMVAFQLFDKAGKGEVTFEDVRQVFGQTTIHQHIPFNWDSEFVQLHFGKERKRHLTYAEFTQFLLEIQLEHAKQAFVQRDNAKTGKVTAIDFRDIMVTIRPHVLTPFVEECLVAAAGGTRSHQVSFSYFNGFNSLLNNMELIRKIYSTLAGSRKDVEVTKEEFALAAQKFGQVTPMEVDILFQLADLYEPRGRMTLADIERIAPLEEGMLPFNLAEAQRQQKASGDAARPFLLQLAESAYRFGLGSIAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLYRGLLPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLLAEIFAGGCAGGSQVIFTNPLEIVKIRLQVAGEITTGPRVSALSVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHVKASFANEDGQVSPGSLLLAGAIAGMPAASLVTPADVIKTRLQVAARAGQTTYSGVTDCFRKILREEGPKALWKGAGARVFRSSPQFGVTLLTYELLQRWFYVDFGGVKPVGSELVPKSRITLPAPNPDHVGGYKLAVATFAGIENKFGLYLPLFKPSASTSKVTAVGS
uniprot
proteins
function
FUNCTION: Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle (PubMed:4436323). Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction (By similarity). Also mediates the uptake of L-cysteinesulfinate (3-sulfino-L-alanine) by mitochondria in exchange for L-glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation (PubMed:486467). Lacks transport activity towards gamma-aminobutyric acid (GABA) (By similarity). {ECO:0000250|UniProtKB:Q9UJS0, ECO:0000269|PubMed:4436323, ECO:0000269|PubMed:486467}.
uniprot
proteins
mass_dalton
74399
uniprot
proteins
protein_family
Mitochondrial carrier (TC 2.A.29) family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
4436323
uniprot
proteins
pubmed
486467
uniprot
proteins
sequence_length
676
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000305|PubMed:4436323, ECO:0000305|PubMed:486467}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 333..350; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:O75746"; TRANSMEM 394..413; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:O75746"; TRANSMEM 437..450; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:O75746"; TRANSMEM 486..505; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:O75746"; TRANSMEM 525..542; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:O75746"; TRANSMEM 582..601; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:O75746
uniprot
proteins