GPR135
entrez
64582
canonical
uniprot
Q8IZ08
canonical
ensembl
ENSG00000181619
resolver
ensp
ENSP00000378548
resolver
ensp
ENSP00000432696
resolver
enst
ENST00000395116
resolver
enst
ENST00000481661
resolver
genesymbol
GPR135
resolver
hgnc
HGNC:19991
resolver
uniprot
Q7Z604
resolver
uniprot
Q86SM3
resolver
uniprot
Q8NH39
resolver
uniprot_entry
GP135_HUMAN
resolver
uniprot_sec
Q7Z604
resolver
uniprot_sec
Q86SM3
resolver
uniprot_sec
Q8NH39
resolver
amino_acid_sequence
MEEPQPPRPPASMALLGSQHSGAPSAAGPPGGTSSAATAAVLSFSTVATAALGNLSDASGGGTAAAPGGGGLGGSGAAREAGAAVRRPLGPEAAPLLSHGAAVAAQALVLLLIFLLSSLGNCAVMGVIVKHRQLRTVTNAFILSLSLSDLLTALLCLPAAFLDLFTPPGGSAPAAAAGPWRGFCAASRFFSSCFGIVSTLSVALISLDRYCAIVRPPREKIGRRRALQLLAGAWLTALGFSLPWELLGAPRELAAAQSFHGCLYRTSPDPAQLGAAFSVGLVVACYLLPFLLMCFCHYHICKTVRLSDVRVRPVNTYARVLRFFSEVRTATTVLIMIVFVICCWGPYCFLVLLAAARQAQTMQAPSLLSVVAVWLTWANGAINPVIYAIRNPNISMLLGRNREEGYRTRNVDAFLPSQGPGLQARSRSRLRNRYANRLGACNRMSSSNPASGVAGDVAMWARKNPVVLFCREGPPEPVTAVTKQPKSEAGDTSL
uniprot
proteins
function
FUNCTION: Orphan receptor. Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538). {ECO:0000269|PubMed:28827538}.
uniprot
proteins
mass_dalton
51736
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
12679517
uniprot
proteins
pubmed
14623098
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
28827538
uniprot
proteins
sequence_length
494
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28827538}; Multi-pass membrane protein {ECO:0000255}. Endosome membrane {ECO:0000269|PubMed:28827538}; Multi-pass membrane protein {ECO:0000255}. Note=Colocalizes with ARRB2/beta-arrestin-2 in the endosome. {ECO:0000269|PubMed:28827538}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..33; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 38..58; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 82..102; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 126..146; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 165..185; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 227..247; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 263..283; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins