PSME3IP1
entrez
80011
canonical
uniprot
Q9GZU8
canonical
ensembl
ENSG00000172775
resolver
ensp
ENSP00000335808
resolver
ensp
ENSP00000456211
resolver
ensp
ENSP00000457740
resolver
ensp
ENSP00000457850
resolver
ensp
ENSP00000540510
resolver
ensp
ENSP00000540511
resolver
ensp
ENSP00000540512
resolver
ensp
ENSP00000540513
resolver
ensp
ENSP00000540515
resolver
ensp
ENSP00000540516
resolver
ensp
ENSP00000540517
resolver
ensp
ENSP00000540518
resolver
ensp
ENSP00000540519
resolver
ensp
ENSP00000540520
resolver
ensp
ENSP00000540521
resolver
ensp
ENSP00000540522
resolver
ensp
ENSP00000540523
resolver
ensp
ENSP00000540524
resolver
ensp
ENSP00000540525
resolver
ensp
ENSP00000540526
resolver
ensp
ENSP00000540528
resolver
ensp
ENSP00000540529
resolver
ensp
ENSP00000540530
resolver
ensp
ENSP00000540531
resolver
ensp
ENSP00000540532
resolver
ensp
ENSP00000540533
resolver
ensp
ENSP00000540534
resolver
ensp
ENSP00000540535
resolver
ensp
ENSP00000540536
resolver
ensp
ENSP00000540537
resolver
ensp
ENSP00000540538
resolver
ensp
ENSP00000540539
resolver
ensp
ENSP00000540540
resolver
ensp
ENSP00000540541
resolver
ensp
ENSP00000540542
resolver
ensp
ENSP00000540543
resolver
ensp
ENSP00000540544
resolver
ensp
ENSP00000540545
resolver
ensp
ENSP00000584719
resolver
ensp
ENSP00000584720
resolver
ensp
ENSP00000584721
resolver
ensp
ENSP00000584722
resolver
ensp
ENSP00000584723
resolver
ensp
ENSP00000584724
resolver
ensp
ENSP00000584725
resolver
ensp
ENSP00000584726
resolver
ensp
ENSP00000584727
resolver
ensp
ENSP00000584728
resolver
ensp
ENSP00000584729
resolver
ensp
ENSP00000584730
resolver
ensp
ENSP00000584731
resolver
ensp
ENSP00000584732
resolver
ensp
ENSP00000584733
resolver
ensp
ENSP00000584734
resolver
ensp
ENSP00000584735
resolver
ensp
ENSP00000584736
resolver
ensp
ENSP00000584737
resolver
ensp
ENSP00000584738
resolver
ensp
ENSP00000584739
resolver
ensp
ENSP00000584740
resolver
ensp
ENSP00000584741
resolver
ensp
ENSP00000584742
resolver
ensp
ENSP00000584743
resolver
ensp
ENSP00000584744
resolver
ensp
ENSP00000584745
resolver
ensp
ENSP00000584746
resolver
ensp
ENSP00000584747
resolver
ensp
ENSP00000584748
resolver
ensp
ENSP00000584749
resolver
ensp
ENSP00000584750
resolver
ensp
ENSP00000584751
resolver
ensp
ENSP00000584752
resolver
ensp
ENSP00000584753
resolver
ensp
ENSP00000584754
resolver
ensp
ENSP00000611722
resolver
ensp
ENSP00000611723
resolver
ensp
ENSP00000611724
resolver
ensp
ENSP00000611725
resolver
ensp
ENSP00000611726
resolver
ensp
ENSP00000611727
resolver
ensp
ENSP00000611728
resolver
ensp
ENSP00000611729
resolver
ensp
ENSP00000611730
resolver
ensp
ENSP00000611731
resolver
ensp
ENSP00000611732
resolver
enst
ENST00000309137
resolver
enst
ENST00000564108
resolver
enst
ENST00000567439
resolver
enst
ENST00000569266
resolver
enst
ENST00000870451
resolver
enst
ENST00000870452
resolver
enst
ENST00000870453
resolver
enst
ENST00000870454
resolver
enst
ENST00000870456
resolver
enst
ENST00000870457
resolver
enst
ENST00000870458
resolver
enst
ENST00000870459
resolver
enst
ENST00000870460
resolver
enst
ENST00000870461
resolver
enst
ENST00000870462
resolver
enst
ENST00000870463
resolver
enst
ENST00000870464
resolver
enst
ENST00000870465
resolver
enst
ENST00000870466
resolver
enst
ENST00000870467
resolver
enst
ENST00000870469
resolver
enst
ENST00000870470
resolver
enst
ENST00000870471
resolver
enst
ENST00000870472
resolver
enst
ENST00000870473
resolver
enst
ENST00000870474
resolver
enst
ENST00000870475
resolver
enst
ENST00000870476
resolver
enst
ENST00000870477
resolver
enst
ENST00000870478
resolver
enst
ENST00000870479
resolver
enst
ENST00000870480
resolver
enst
ENST00000870481
resolver
enst
ENST00000870482
resolver
enst
ENST00000870483
resolver
enst
ENST00000870484
resolver
enst
ENST00000870485
resolver
enst
ENST00000870486
resolver
enst
ENST00000914660
resolver
enst
ENST00000914661
resolver
enst
ENST00000914662
resolver
enst
ENST00000914663
resolver
enst
ENST00000914664
resolver
enst
ENST00000914665
resolver
enst
ENST00000914666
resolver
enst
ENST00000914667
resolver
enst
ENST00000914668
resolver
enst
ENST00000914669
resolver
enst
ENST00000914670
resolver
enst
ENST00000914671
resolver
enst
ENST00000914672
resolver
enst
ENST00000914673
resolver
enst
ENST00000914674
resolver
enst
ENST00000914675
resolver
enst
ENST00000914676
resolver
enst
ENST00000914677
resolver
enst
ENST00000914678
resolver
enst
ENST00000914679
resolver
enst
ENST00000914680
resolver
enst
ENST00000914681
resolver
enst
ENST00000914682
resolver
enst
ENST00000914683
resolver
enst
ENST00000914684
resolver
enst
ENST00000914685
resolver
enst
ENST00000914686
resolver
enst
ENST00000914687
resolver
enst
ENST00000914688
resolver
enst
ENST00000914689
resolver
enst
ENST00000914690
resolver
enst
ENST00000914691
resolver
enst
ENST00000914692
resolver
enst
ENST00000914693
resolver
enst
ENST00000914694
resolver
enst
ENST00000914695
resolver
enst
ENST00000941663
resolver
enst
ENST00000941664
resolver
enst
ENST00000941665
resolver
enst
ENST00000941666
resolver
enst
ENST00000941667
resolver
enst
ENST00000941668
resolver
enst
ENST00000941669
resolver
enst
ENST00000941670
resolver
enst
ENST00000941671
resolver
enst
ENST00000941672
resolver
enst
ENST00000941673
resolver
genesymbol
PSME3IP1
resolver
genesymbol_syn
C16orf94
resolver
genesymbol_syn
FAM192A
resolver
genesymbol_syn
NIP30
resolver
genesymbol_syn
PIP30
resolver
hgnc
HGNC:29856
resolver
uniprot_entry
PIP30_HUMAN
resolver
amino_acid_sequence
MDGGDDGNLIIKKRFVSEAELDERRKRRQEEWEKVRKPEDPEECPEEVYDPRSLYERLQEQKDRKQQEYEEQFKFKNMVRGLDEDETNFLDEVSRQQELIEKQRREEELKELKEYRNNLKKVGISQENKKEVEKKLTVKPIETKNKFSQAKLLAGAVKHKSSESGNSVKRLKPDPEPDDKNQEPSSCKSLGNTSLSGPSIHCPSAAVCIGILPGLGAYSGSSDSESSSDSEGTINATGKIVSSIFRTNTFLEAP
uniprot
proteins
function
FUNCTION: Promotes the association of the proteasome activator complex subunit PSME3 with the 20S proteasome and regulates its activity. Inhibits PSME3-mediated degradation of some proteasome substrates, probably by affecting their diffusion rate into the catalytic chamber of the proteasome. Also inhibits the interaction of PSME3 with COIL, inhibits accumulation of PSME3 in Cajal bodies and positively regulates the number of Cajal bodies in the nucleus. {ECO:0000269|PubMed:29934401}.
uniprot
proteins
mass_dalton
28912
uniprot
proteins
mutagenesis
MUTAGEN 222; /note="S->A: Reduces phosphorylation by CK2 and interaction with PSME3; when associated with A-228."; /evidence="ECO:0000269|PubMed:29934401"; MUTAGEN 223..225; /note="DSE->KSK: Abolishes phosphorylation by CK2, strongly reduces interaction with PSME3 and abolishes effect on proteasome activity."; /evidence="ECO:0000269|PubMed:29934401"; MUTAGEN 228; /note="S->A: Reduces phosphorylation by CK2 and interaction with PSME3; when associated with A-222."; /evidence="ECO:0000269|PubMed:29934401"; MUTAGEN 229..231; /note="DSE->KSK: Strongly reduces phosphorylation by CK2 and interaction with PSME3."; /evidence="ECO:0000269|PubMed:29934401
uniprot
proteins
post_translational_modification
PTM: Phosphorylation by CK2 stabilizes the interaction with PSME3. {ECO:0000269|PubMed:29934401}.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
29934401
uniprot
proteins
sequence_length
254
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29934401}.
uniprot
proteins