Ppp1ca
entrez
24668
canonical
uniprot
P62138
canonical
ensembl
ENSRNOG00000018708
resolver
ensembl
ENSRNOG00055018818
resolver
ensembl
ENSRNOG00060032889
resolver
ensembl
ENSRNOG00065033319
resolver
ensp
ENSRNOP00000025282
resolver
ensp
ENSRNOP00055025944
resolver
ensp
ENSRNOP00060047089
resolver
ensp
ENSRNOP00065047113
resolver
enst
ENSRNOT00000025282
resolver
enst
ENSRNOT00055032085
resolver
enst
ENSRNOT00060057009
resolver
enst
ENSRNOT00065057272
resolver
genesymbol
Ppp1ca
resolver
genesymbol_syn
Ppp1a
resolver
uniprot
P08129
resolver
uniprot
P20653
resolver
uniprot
P22802
resolver
uniprot_entry
PP1A_RAT
resolver
uniprot_sec
P08129
resolver
uniprot_sec
P20653
resolver
uniprot_sec
P22802
resolver
amino_acid_sequence
MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPADKNKGKYGQFSGLNPGGRPITPPRNSAKAKK
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, transcription elongation, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Catalytic component of the PNUTS-PP1 protein phosphatase complex, a protein phosphatase 1 (PP1) complex that promotes RNA polymerase II transcription pause-release, allowing transcription elongation: the PNUTS-PP1 complex mediates the release of RNA polymerase II from promoter-proximal region of genes by catalyzing dephosphorylation of proteins involved in transcription, such as AFF4, CDK9, MEPCE, INTS12, NCBP1, POLR2M/GDOWN1 and SUPT6H. The PNUTS-PP1 complex also regulates transcription termination by mediating dephosphorylation of SUPT5H in termination zones downstream of poly(A) sites, thereby promoting deceleration of RNA polymerase II transcription. PNUTS-PP1 complex is also involved in the response to replication stress by mediating dephosphorylation of POLR2A at 'Ser-5' of the CTD, promoting RNA polymerase II degradation. PNUTS-PP1 also plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage (By similarity). Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development (By similarity). In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective. Dephosphorylates CENPA. Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy. Together with PPP1CC (PP1-gamma subunit), dephosphorylates IFIH1/MDA5 and RIG-I leading to their activation and a functional innate immune response. Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation. The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities. The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c (By similarity). {ECO:0000250|UniProtKB:P62136, ECO:0000250|UniProtKB:P62137}.
uniprot
proteins
mass_dalton
37512
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Dephosphorylated at Thr-320 in the presence of ionizing radiation. {ECO:0000250|UniProtKB:P62136}.
uniprot
proteins
protein_family
PP-1 subfamily
uniprot
proteins
protein_family
PPP phosphatase family
uniprot
proteins
pubmed
10504266
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1650776
uniprot
proteins
pubmed
17890166
uniprot
proteins
pubmed
2177460
uniprot
proteins
pubmed
7751917
uniprot
proteins
sequence_length
330
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62136}. Nucleus {ECO:0000250|UniProtKB:P62136}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:P62136}. Nucleus, nucleolus {ECO:0000250|UniProtKB:P62136}. Postsynaptic density {ECO:0000250|UniProtKB:P62137}. Note=Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting it to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles. {ECO:0000250|UniProtKB:P62136}.
uniprot
proteins