Fxyd1
entrez
58971
canonical
uniprot
O08589
canonical
ensembl
ENSRNOG00000021079
resolver
ensp
ENSRNOP00000028624
resolver
ensp
ENSRNOP00000083421
resolver
enst
ENSRNOT00000028624
resolver
enst
ENSRNOT00000102674
resolver
genesymbol
Fxyd1
resolver
genesymbol_syn
Plm
resolver
uniprot
A0A0H2UHS8
resolver
uniprot_entry
A0A0H2UHS8_RAT
resolver
uniprot_entry
PLM_RAT
resolver
amino_acid_sequence
MASPGHILIVCVCLLSMASAEAPQEPDPFTYDYHTLRIGGLTIAGILFILGILIILSKRCRCKFNQQQRTGEPDEEEGTFRSSIRRLSTRRR
uniprot
proteins
function
FUNCTION: Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell (By similarity). Inhibits NKA activity in its unphosphorylated state and stimulates activity when phosphorylated (PubMed:17283221). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (By similarity). Contributes to female sexual development by maintaining the excitability of neurons which secrete gonadotropin-releasing hormone (By similarity). {ECO:0000250|UniProtKB:P56513, ECO:0000250|UniProtKB:Q9Z239, ECO:0000269|PubMed:17283221}.
uniprot
proteins
mass_dalton
10365
uniprot
proteins
post_translational_modification
PTM: Major plasma membrane substrate for cAMP-dependent protein kinase (PKA) and protein kinase C (PKC) in several different tissues (By similarity). Phosphorylated in response to insulin and adrenergic stimulation (By similarity). Phosphorylation at Ser-88 stimulates sodium/potassium-transporting ATPase activity while the unphosphorylated form inhibits sodium/potassium-transporting ATPase activity (PubMed:17283221). Phosphorylation increases tetramerization, decreases binding to ATP1A1 and reduces inhibition of ATP1A1 activity (By similarity). Phosphorylation at Ser-83 leads to greatly reduced interaction with ATP1A1, ATP1A2 and ATP1A3 (PubMed:23532852). May be phosphorylated by DMPK (By similarity). {ECO:0000250|UniProtKB:O00168, ECO:0000250|UniProtKB:P56513, ECO:0000269|PubMed:17283221, ECO:0000269|PubMed:23532852}.; PTM: Palmitoylation increases half-life and stability and is enhanced upon phosphorylation at Ser-88 by PKA. {ECO:0000250|UniProtKB:O00168}.
uniprot
proteins
protein_family
FXYD family
uniprot
proteins
pubmed
10950925
uniprot
proteins
pubmed
12657675
uniprot
proteins
pubmed
17283221
uniprot
proteins
pubmed
19187398
uniprot
proteins
pubmed
19339511
uniprot
proteins
pubmed
23532852
uniprot
proteins
pubmed
9169143
uniprot
proteins
sequence_length
92
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane, sarcolemma {ECO:0000269|PubMed:23532852}; Single-pass type I membrane protein {ECO:0000255}. Apical cell membrane {ECO:0000269|PubMed:12657675}; Single-pass type I membrane protein {ECO:0000255}. Membrane, caveola {ECO:0000269|PubMed:23532852}. Cell membrane, sarcolemma, T-tubule {ECO:0000269|PubMed:23532852}. Note=Detected in the apical cell membrane in brain (PubMed:12657675). In myocytes, localizes to sarcolemma, t-tubules and intercalated disks (PubMed:23532852). {ECO:0000269|PubMed:12657675, ECO:0000269|PubMed:23532852}.
uniprot
proteins
transmembrane_region
TRANSMEM 36..56; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins