NPY
entrez
4852
canonical
uniprot
P01303
canonical
ensembl
ENSG00000122585
resolver
ensp
ENSP00000242152
resolver
ensp
ENSP00000384364
resolver
ensp
ENSP00000385282
resolver
ensp
ENSP00000595320
resolver
enst
ENST00000242152
resolver
enst
ENST00000405982
resolver
enst
ENST00000407573
resolver
enst
ENST00000925261
resolver
genesymbol
NPY
resolver
hgnc
HGNC:7955
resolver
uniprot
A4D158
resolver
uniprot_entry
A4D158_HUMAN
resolver
uniprot_entry
NPY_HUMAN
resolver
amino_acid_sequence
MLGNKRLGLSGLTLALSLLVCLGALAEAYPSKPDNPGEDAPAEDMARYYSALRHYINLITRQRYGKRSSPETLISDLLMRESTENVPRTRLEDPAMW
uniprot
proteins
function
FUNCTION: [Neuropeptide Y]: Ligand for neuropeptide Y receptor type 1 (NPY1R) and neuropeptide Y receptor type 2 (NPY2R) (PubMed:1321422, PubMed:7592910, PubMed:35165283, PubMed:35507650, PubMed:36525977, PubMed:38882210). Receptor binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production (PubMed:1321422, PubMed:7592910, PubMed:38882210). Receptor activation by NPY also leads to an increase of intracellular Ca(2+) levels (PubMed:1321422, PubMed:35165283, PubMed:7592910). Is involved in the regulation of eating behavior, acting as a stimulator of food intake (By similarity). Involved in the regulation of colonic antisecretory tone, and colonic contractility (By similarity). {ECO:0000250|UniProtKB:P07808, ECO:0000250|UniProtKB:P57774, ECO:0000269|PubMed:1321422, ECO:0000269|PubMed:35165283, ECO:0000269|PubMed:35507650, ECO:0000269|PubMed:36525977, ECO:0000269|PubMed:38882210, ECO:0000269|PubMed:7592910}.
uniprot
proteins
mass_dalton
10851
uniprot
proteins
mutagenesis
MUTAGEN 1..30; /note="Missing: Decreased NPY1R activation and signaling."; /evidence="ECO:0000269|PubMed:35165283"; MUTAGEN 29..30; /note="YP->AA: Decreased NPY1R activation and signaling."; /evidence="ECO:0000269|PubMed:35165283"; MUTAGEN 59; /note="I->L: Has no effect on NPY1R activation and signaling; when associated in cis with P-62. Decreased NPY2R activation and signaling; when associated in cis with P-62."; /evidence="ECO:0000269|PubMed:1321422, ECO:0000269|PubMed:38882210"; MUTAGEN 62; /note="Q->P: Has no effect on NPY1R activation and signaling; when associated in cis with L-59. Decreased NPY2R activation and signaling; when associated in cis with L-59."; /evidence="ECO:0000269|PubMed:1321422, ECO:0000269|PubMed:38882210
uniprot
proteins
post_translational_modification
PTM: The neuropeptide Y form is cleaved at Pro-30 by the prolyl endopeptidase FAP (seprase) activity (in vitro). {ECO:0000269|PubMed:21314817}.
uniprot
proteins
protein_family
NPY family
uniprot
proteins
pubmed
10561544
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
1321422
uniprot
proteins
pubmed
1425680
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21314817
uniprot
proteins
pubmed
2427515
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
35165283
uniprot
proteins
pubmed
35180645
uniprot
proteins
pubmed
35217654
uniprot
proteins
pubmed
35507650
uniprot
proteins
pubmed
36525977
uniprot
proteins
pubmed
3753985
uniprot
proteins
pubmed
3839058
uniprot
proteins
pubmed
38882210
uniprot
proteins
pubmed
6589611
uniprot
proteins
pubmed
7592910
uniprot
proteins
pubmed
7593641
uniprot
proteins
pubmed
9008359
uniprot
proteins
sequence_length
97
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:7593641}. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle {ECO:0000250|UniProtKB:P07808}.
uniprot
proteins