SLC7A3
entrez
84889
canonical
uniprot
Q8WY07
canonical
ensembl
ENSG00000165349
resolver
ensp
ENSP00000298085
resolver
ensp
ENSP00000363417
resolver
ensp
ENSP00000591076
resolver
ensp
ENSP00000591077
resolver
ensp
ENSP00000591078
resolver
enst
ENST00000298085
resolver
enst
ENST00000374299
resolver
enst
ENST00000921017
resolver
enst
ENST00000921018
resolver
enst
ENST00000921019
resolver
genesymbol
SLC7A3
resolver
genesymbol_syn
ATRC3
resolver
genesymbol_syn
CAT3
resolver
hgnc
HGNC:11061
resolver
uniprot
D3DVU7
resolver
uniprot
Q5JQR2
resolver
uniprot
Q8N185
resolver
uniprot
Q8NCA7
resolver
uniprot
Q96SZ7
resolver
uniprot_entry
CTR3_HUMAN
resolver
uniprot_sec
D3DVU7
resolver
uniprot_sec
Q5JQR2
resolver
uniprot_sec
Q8N185
resolver
uniprot_sec
Q8NCA7
resolver
uniprot_sec
Q96SZ7
resolver
amino_acid_sequence
MPWQAFRRFGQKLVRRRTLESGMAETRLARCLSTLDLVALGVGSTLGAGVYVLAGEVAKDKAGPSIVICFLVAALSSVLAGLCYAEFGARVPRSGSAYLYSYVTVGELWAFTTGWNLILSYVIGTASVARAWSSAFDNLIGNHISKTLQGSIALHVPHVLAEYPDFFALGLVLLLTGLLALGASESALVTKVFTGVNLLVLGFVMISGFVKGDVHNWKLTEEDYELAMAELNDTYSLGPLGSGGFVPFGFEGILRGAATCFYAFVGFDCIATTGEEAQNPQRSIPMGIVISLSVCFLAYFAVSSALTLMMPYYQLQPESPLPEAFLYIGWAPARYVVAVGSLCALSTSLLGSMFPMPRVIYAMAEDGLLFRVLARIHTGTRTPIIATVVSGIIAAFMAFLFKLTDLVDLMSIGTLLAYSLVSICVLILRYQPDQETKTGEEVELQEEAITTESEKLTLWGLFFPLNSIPTPLSGQIVYVCSSLLAVLLTALCLVLAQWSVPLLSGDLLWTAVVVLLLLLIIGIIVVIWRQPQSSTPLHFKVPALPLLPLMSIFVNIYLMMQMTAGTWARFGVWMLIGFAIYFGYGIQHSLEEIKSNQPSRKSRAKTVDLDPGTLYVHSV
uniprot
proteins
function
FUNCTION: Uniporter that mediates the uptake of cationic L-amino acids such as L-arginine, L-lysine and L-ornithine (PubMed:11591158). The transport is sodium ions- and pH-independent, moderately trans-stimulated and is mediated by passive diffusion (PubMed:11591158). {ECO:0000269|PubMed:11591158}.
uniprot
proteins
mass_dalton
67169
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:11591158}.
uniprot
proteins
protein_family
Amino acid-polyamine-organocation (APC) superfamily
uniprot
proteins
protein_family
Cationic amino acid transporter (CAT) (TC 2.A.3.3) family
uniprot
proteins
pubmed
11591158
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
21248752
uniprot
proteins
pubmed
21406692
uniprot
proteins
sequence_length
619
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
uniprot
proteins
transmembrane_region
TRANSMEM 37..57; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 62..82; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 108..128; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 163..183; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 192..212; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 234..254; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 286..306; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 336..356; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 383..403; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 407..427; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 476..496; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 507..527; /note="Helical; Name=12"; /evidence="ECO:0000255"; TRANSMEM 541..561; /note="Helical; Name=13"; /evidence="ECO:0000255"; TRANSMEM 570..590; /note="Helical; Name=14"; /evidence="ECO:0000255
uniprot
proteins