Cspg4
entrez
121021
canonical
uniprot
Q8VHY0
canonical
ensembl
ENSMUSG00000032911
resolver
ensp
ENSMUSP00000038909
resolver
genesymbol
Cspg4
resolver
genesymbol_syn
An2
resolver
genesymbol_syn
Kiaa4232
resolver
genesymbol_syn
Ng2
resolver
uniprot
G5E892
resolver
uniprot
Q3URZ9
resolver
uniprot
Q5DTG1
resolver
uniprot
Q8BPI8
resolver
uniprot
Q8CE79
resolver
uniprot_entry
CSPG4_MOUSE
resolver
uniprot_entry
Q3URZ9_MOUSE
resolver
uniprot_sec
G5E892
resolver
uniprot_sec
Q5DTG1
resolver
uniprot_sec
Q8BPI8
resolver
uniprot_sec
Q8CE79
resolver
amino_acid_sequence
MLLGPGHPLSAPALALALTLALLVRSTAPASFFGENHLEVPVPSALTRVDLLLQFSTSQPEALLLLAAGQDDHLLLQLHSGCLQVRLALGQKELKLQTPADTVLSDSAPHTVVLTVSDSWAVLSVDGVLNTSAPIPRASHLKATYGLFVGSSGSLDLPYLKGISRPLRGCLHSAILNGRNLLRPLTSDVHEGCAEEFSAGDEVGLGFSGPHSLAAFPAWSTREEGTLEFTLTTRSQQAPLAFQAGDKRGNFIYVDIFEGHLRAVVEKGQGTMLLRNSVPVADGQPHEVSVHIDVHRLEISVDQYPTRTFNRGVLSYLEPRGSLLLGGLDTEASRHLQEHRLGLAPGAANISLVGCIEDFSVNGRRQGLRDAWLTRDMSAGCRPEEDEYEEEVYGPYETFSTLAPEAWPAMELPEPCIPEPGLPAVFANFTQLLTISPLVVAEGGTAWLEWRHVQPTLDLTEAELRKSQVLFSVSQSARHGDLELDILGAQTRKMFTLLDVVNRKARFVHDGSEDTSDQLMLEVSVTARAPVPSCLRRGQIYILPIQVNPVNDPPRIIFPHGSLMVILEHTQKPLGPEIFQAYDPDSACEGLTFQLLGVSSGVPVEHRDQPGEPATEFSCRELEVGDIVYVHRGGPAQDLTFRVSDGMQASAPATLKVVAVRPAIQILHNTGLHLAQGSAAAILPANLSVETNAVGQDVSVLFRVTGTLQFGELQKQGAGGVEGTEWWDTLAFHQRDVEQGRVRYLSTDPQHHTQDTVEDLILEVQVGQETLSNLSFPVTIQRATVWMLRLEPLHTQNPHQETLTPAHLEASLEEEEEEGSPQPHTFHYELVQAPRRGNLLLQGTRLSDGESFSQSDLQAGRVTYRATMRTSEAADDSFRFRVTSPPHFSPLYTFPIHIGGDPNAPVLTNVLLMVPEGGEGVLSADHLFVKSLNSASYLYEVMEQPHHGKLAWRDPKGKSTPVTSFTNEDLLHGRLVYQHDDSETIEDDIPFVATRQGEGSGDMAWEEVRGVFRVAIQPVNDHAPVQTISRVFHVARGGQRLLTTDDVAFSDADSGFSDAQLVLTRKDLLFGSIVAMEEPTRPIYRFTQEDLRKKQVLFVHSGADHGWLQLQVSDGQHQATAMLEVQASEPYLHVANSSSLVVPQGGQGTIDTAVLQLDTNLDIRSGNEVHYHVTAGPQWGQLLRDGQSVTSFSQRDLLDGAILYSHNGSLSPQDTLAFSVAAGPVHTNTFLQVTIALEGPLAPLQLVQHKKIYVFQGEAAEIRRDQLEVVQEAVLPADIMFSLRSPPNAGYLVMVSHGASAEEPPSLDPVQSFSQEAVNSGRVLYLHSRPGAWSDSFSLDVASGLGDPLEGISVELEVLPTVIPLDVQNFSVPEGGTRTLAPPLVQITGPYFPTLPGLVLQVLEPPQHGALQKEDHSQDGSLSTFSWREVEEQLIRYVHDGSETQTDAFVLLANASEMDRQSQPVAFTITILPVNDQPPVLTTNTGLQIWEGAIVPIPPEALRGTDNDSGPEDLVYTIEQPSNGRIALRVAPDTEVHRFTQAQLDSGLVLFSHRGALEGGFHFDLSDGAHTSPGHFFRVVAQKQALLSLEGTRKLTVCPESVQPLSSQSLSASSSTGADPRHLLYRVVRGPQLGRLLHAQQGSAEEVLVNFTQAEVNAGNILYEHEMSSEPFWEAHDTIGLLLSSPPARDLAATLAVMVSFDAACPQRPSRLWKNKGLWVPEGQRAKITVAALDAANLLASVPASQRSRHDVLFQVTQFPTRGQLLVSEEPLHARRPYFLQSELAAGQLVYAHGGGGTQQDGFRFRAHLQGPTGTSVAGPQTSEAFVITVRDVNERPPQPQASIPLRVTRGSRAPVSRAQLSVVDPDSAPGEIEYEVQRAPHNGFLSLAGDNTGPVTHFTQADVDAGRLAFVANGSSVAGVFQLSMSDGASPPIPMSLAVDVLPSTIEVQLRAPLEVPQALGRTSLSRQQLQVISDREEPDVAYRLTQGPLYGQLLVGGQPASAFSQLQVDQGDVVFVFTNFSSSQDHFKVVALARGVNASATVNVTVQALLHVWAGGPWPQGTTLRLDPTVLDASELANRTGSMPHFRLLAGPRYGRVVRVSQGRTESRSNQLVEHFTQRDLEEGQLGLEVGKPEGRSTGPAGDRLTLELWAKGVPPAVALLDFATEPYHAAKSYSVALLSVPEAVRTETEKPGRSVPTGQPGQAASSPVPTAAKGGFLGFLEANMFSIIIPVCLILLLLALILPLLFYLRKRNKTGKHDVQVLTAKPRNGLAGDTETFRKVEPGQAIPLITVPGQGPPPGGQPDPELLQFCRTPNPALRNGQYWV
uniprot
proteins
function
FUNCTION: Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Also functions as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades. {ECO:0000269|PubMed:10036240, ECO:0000269|PubMed:15181153}.
uniprot
proteins
mass_dalton
252309
uniprot
proteins
mutagenesis
MUTAGEN 2324; /note="Q->G: No effect on interaction with GRIP1 and GRIP2."; /evidence="ECO:0000269|PubMed:12458226"; MUTAGEN 2325; /note="Y->F: No effect on interaction with GRIP1 and GRIP2."; /evidence="ECO:0000269|PubMed:12458226"; MUTAGEN 2325; /note="Y->G: Loss of interaction with GRIP1 and GRIP2."; /evidence="ECO:0000269|PubMed:12458226"; MUTAGEN 2326; /note="W->G: Loss of interaction with GRIP1 and GRIP2."; /evidence="ECO:0000269|PubMed:12458226"; MUTAGEN 2327; /note="V->G: Loss of interaction with GRIP1 and GRIP2."; /evidence="ECO:0000269|PubMed:12458226
uniprot
proteins
post_translational_modification
PTM: O-glycosylated; contains glycosaminoglycan chondroitin sulfate which are required for proper localization and function in stress fiber formation. Involved in interaction with MMP16 and ITGA4 (By similarity). {ECO:0000250}.; PTM: Phosphorylation by PRKCA regulates its subcellular location and function in cell motility. {ECO:0000250}.
uniprot
proteins
pubmed
10036240
uniprot
proteins
pubmed
12458226
uniprot
proteins
pubmed
15181153
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
2327
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12458226}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q00657}; Extracellular side {ECO:0000250|UniProtKB:Q00657}. Apical cell membrane {ECO:0000250|UniProtKB:Q00657}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q00657}; Extracellular side {ECO:0000250|UniProtKB:Q00657}. Cell projection, lamellipodium membrane {ECO:0000250|UniProtKB:Q00657}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:Q00657}; Extracellular side {ECO:0000250|UniProtKB:Q00657}. Cell surface {ECO:0000250|UniProtKB:Q00657}. Note=Localized at the apical plasma membrane it relocalizes to the lamellipodia of astrocytoma upon phosphorylation by PRKCA. Localizes to the retraction fibers. A fraction may undergo cell surface proteolysis and secretion (By similarity). Localizes to the plasma membrane of oligodendrocytes (PubMed:12458226). {ECO:0000250|UniProtKB:Q00657, ECO:0000269|PubMed:12458226}.
uniprot
proteins
transmembrane_region
TRANSMEM 2230..2250; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins