Cnot2
entrez
72068
canonical
uniprot
Q8C5L3
canonical
ensembl
ENSMUSG00000020166
resolver
ensp
ENSMUSP00000020374
resolver
ensp
ENSMUSP00000100900
resolver
ensp
ENSMUSP00000100902
resolver
ensp
ENSMUSP00000127830
resolver
ensp
ENSMUSP00000132315
resolver
ensp
ENSMUSP00000195826
resolver
ensp
ENSMUSP00000195827
resolver
ensp
ENSMUSP00000195832
resolver
ensp
ENSMUSP00000195884
resolver
ensp
ENSMUSP00000195886
resolver
enst
ENSMUST00000020374
resolver
enst
ENSMUST00000164088
resolver
enst
ENSMUST00000168036
resolver
genesymbol
Cnot2
resolver
uniprot
A0A1S6GWJ6
resolver
uniprot
E9Q027
resolver
uniprot
H7BWX6
resolver
uniprot
Q3UE39
resolver
uniprot
Q5CZY5
resolver
uniprot
Q80YA5
resolver
uniprot
Q9D0P1
resolver
uniprot_entry
A0A1S6GWJ6_MOUSE
resolver
uniprot_entry
CNOT2_MOUSE
resolver
uniprot_entry
E9Q027_MOUSE
resolver
uniprot_entry
H7BWX6_MOUSE
resolver
uniprot_entry
Q5CZY5_MOUSE
resolver
uniprot_sec
Q3UE39
resolver
uniprot_sec
Q80YA5
resolver
uniprot_sec
Q9D0P1
resolver
amino_acid_sequence
MVRTDGHTLSEKRNYQVTNSMFGASRKKFVEGVDSDYHDENMYYSQSSMFPHRSEKDMLASPSTSGQLSQFGASLYGQQSALGLPMRGMSNNTPQLNRSLSQGTQLPSHVTPTTGVPTMSLHTPPSPSRGILPMNPRNMMNHSQVGQGIGIPSRTNSMSSSGLGSPNRSSPSIICMPKQQPSRQPFTVNSMSGFGMNRNQAFGMNNSLSSNIFNGTDGSENVTGLDLSDFPALADRNRREGSGNPTPLINPLAGRAPYVGMVTKPANEQSQDFSIHNEDFPALPGSSYKDPTSSNDDSKSNLSTSGKTTSSTDGPKFPGDKSSTTQNNNQQKKGIQVLPDGRVTNIPQGMVTDQFGMIGLLTFIRAAETDPGMVHLALGSDLTTLGLNLNSPENLYPKFASPWASSPCRPQDIDFHVPSEYLTNIHIRDKLAAIKLGRYGEDLLFYLYYMNGGDVLQLLAAVELFNRDWRYHKEERVWITRAPGMEPTMKTNTYERGTYYFFDCLNWRKVAKEFHLEYDKLEERPHLPSTFNYNPAQQAF
uniprot
proteins
function
FUNCTION: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity; prevents their differentiation towards extraembryonic trophectoderm lineages. {ECO:0000269|PubMed:22367759}.
uniprot
proteins
mass_dalton
59711
uniprot
proteins
protein_family
CNOT2/3/5 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22367759
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
540
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000305}.
uniprot
proteins