MAGI3
entrez
260425
canonical
uniprot
Q5TCQ9
canonical
ensembl
ENSG00000081026
resolver
ensp
ENSP00000304604
resolver
ensp
ENSP00000358624
resolver
ensp
ENSP00000358628
resolver
ensp
ENSP00000686866
resolver
ensp
ENSP00000686868
resolver
genesymbol
MAGI3
resolver
genesymbol_syn
KIAA1634
resolver
hgnc
HGNC:29647
resolver
uniprot
A0A024R0E9
resolver
uniprot
A0A024R0H3
resolver
uniprot
Q5TCQ8
resolver
uniprot
Q5TCR0
resolver
uniprot
Q9H2V6
resolver
uniprot
Q9H5Y8
resolver
uniprot
Q9HBC4
resolver
uniprot
Q9HCD8
resolver
uniprot_entry
MAGI3_HUMAN
resolver
uniprot_sec
A0A024R0E9
resolver
uniprot_sec
A0A024R0H3
resolver
uniprot_sec
Q5TCQ8
resolver
uniprot_sec
Q5TCR0
resolver
uniprot_sec
Q9H2V6
resolver
uniprot_sec
Q9H5Y8
resolver
uniprot_sec
Q9HBC4
resolver
uniprot_sec
Q9HCD8
resolver
amino_acid_sequence
MSKTLKKKKHWLSKVQECAVSWAGPPGDFGAEIRGGAERGEFPYLGRLREEPGGGTCCVVSGKAPSPGDVLLEVNGTPVSGLTNRDTLAVIRHFREPIRLKTVKPGKVINKDLRHYLSLQFQKGSIDHKLQQVIRDNLYLRTIPCTTRAPRDGEVPGVDYNFISVEQFKALEESGALLESGTYDGNFYGTPKPPAEPSPFQPDPVDQVLFDNEFDAESQRKRTTSVSKMERMDSSLPEEEEDEDKEAINGSGNAENRERHSESSDWMKTVPSYNQTNSSMDFRNYMMRDETLEPLPKNWEMAYTDTGMIYFIDHNTKTTTWLDPRLCKKAKAPEDCEDGELPYGWEKIEDPQYGTYYVDHLNQKTQFENPVEEAKRKKQLGQVEIGSSKPDMEKSHFTRDPSQLKGVLVRASLKKSTMGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCVLGHTHADVVQMFQLVPVNQYVNLTLCRGYPLPDDSEDPVVDIVAATPVINGQSLTKGETCMNPQDFKPGAMVLEQNGKSGHTLTGDGLNGPSDASEQRVSMASSGSSQPELVTIPLIKGPKGFGFAIADSPTGQKVKMILDSQWCQGLQKGDIIKEIYHQNVQNLTHLQVVEVLKQFPVGADVPLLILRGGPPSPTKTAKMKTDKKENAGSLEAINEPIPQPMPFPPSIIRSGSPKLDPSEVYLKSKTLYEDKPPNTKDLDVFLRKQESGFGFRVLGGDGPDQSIYIGAIIPLGAAEKDGRLRAADELMCIDGIPVKGKSHKQVLDLMTTAARNGHVLLTVRRKIFYGEKQPEDDSSQAFISTQNGSPRLNRAEVPARPAPQEPYDVVLQRKENEGFGFVILTSKNKPPPGVIPHKIGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVIAEEEHHGPPSGTNSARQSPALQHRPMGQSQANHIPGDRSALEGEIGKDVSTSYRHSWSDHKHLAQPDTAVISVVGSRHNQNLGCYPVELERGPRGFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQAGGNKVLLLLRPGTGLIPDHGDWDINNPSSSNVIYDEQSPLPPSSHFASIFEESHVPVIEESLRVQICEKAEELKDIVPEKKSTLNENQPEIKHQSLLQKNVSKRDPPSSHGHSNKKNLLKVENGVTRRGRSVSPKKPASQHSEEHLDKIPSPLKNNPKRRPRDQSLSPSKGENKSCQVSTRAGSGQDQCRKSRGRSASPKKQQKIEGSKAPSNAEAKLLEGKSRRIAGYTGSNAEQIPDGKEKSDVIRKDAKQNQLEKSRTRSPEKKIKRMVEKSLPSKMTNKTTSKEVSENEKGKKVTTGETSSSNDKIGENVQLSEKRLKQEPEEKVVSNKTEDHKGKELEAADKNKETGRFKPESSSPVKKTLITPGPWKVPSGNKVTGTIGMAEKRQ
uniprot
proteins
function
FUNCTION: Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2. {ECO:0000269|PubMed:10748157}.
uniprot
proteins
mass_dalton
162949
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated following interaction with HPV E6 protein, leading to its degradation by the proteasome. Degradation is independent of E6AP ubiquitin ligase complex.
uniprot
proteins
protein_family
MAGUK family
uniprot
proteins
pubmed
10748157
uniprot
proteins
pubmed
10997877
uniprot
proteins
pubmed
11969287
uniprot
proteins
pubmed
12140759
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15003862
uniprot
proteins
pubmed
15378012
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15507623
uniprot
proteins
pubmed
15652357
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16904289
uniprot
proteins
pubmed
17055267
uniprot
proteins
pubmed
17934525
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23873930
uniprot
proteins
sequence_length
1481
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein. Cell junction, tight junction. Nucleus {ECO:0000250}. Note=Concentrates in specific sites at the plasma membrane and in the nucleus. In epithelial cells, it localizes at tight junctions (By similarity). {ECO:0000250}.
uniprot
proteins