Arhgap17
entrez
63994
canonical
uniprot
Q99N37
canonical
ensembl
ENSRNOG00000013836
resolver
ensp
ENSRNOP00000019305
resolver
ensp
ENSRNOP00000019309
resolver
ensp
ENSRNOP00000038504
resolver
ensp
ENSRNOP00000076440
resolver
ensp
ENSRNOP00000080152
resolver
enst
ENSRNOT00000105291
resolver
genesymbol
Arhgap17
resolver
uniprot
A0A8I5ZP42
resolver
uniprot
Q8R506
resolver
uniprot
Q99N38
resolver
uniprot
Q9EQV7
resolver
uniprot_entry
A0A8I5ZP42_RAT
resolver
uniprot_entry
RHG17_RAT
resolver
uniprot_sec
Q8R506
resolver
uniprot_sec
Q99N38
resolver
uniprot_sec
Q9EQV7
resolver
amino_acid_sequence
MKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSMCHHSHKRLIACFQGQHGTDAERRHKKLPLTALAQNMQEASAQLEESLLGKMLETCGDAENQLAFELSQHEVFVEKEIMDPLYGIAEVEIPNIQKQRKQLARLVLDWDSVRARWNQAHKSSGTNFQGLPSKIDTLKEEMDEAGNKVEQCKDQLAADMYNFMAKEGEYGKFFVTLLEAQADYHRKALAVLEKALPEMRAHQDKWAEKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCSTSHLDEFYSDPHAVAGALKSYLRELPEPLMTFSLYEEWTQVASVQDQDKKLQYLWTTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWAKQEGTLAEIAAATSVHVVAVIEPIIQHADWFFPGEVEFNVSEAFVPLATPNSNHSSHTGNDSDSGTLERKRPASMAVMEGDLVKKESFGVKLMDFQAHRRGGTLNRKHISPAFQPPLPPTDGNALAPAGPELPSQSSRADSNSVGGPVPSSSGILEQGLSPGDSSPPKPKDSVSAAAPVAGRNSNQITTVPNQAQTGGNSHQLSVGTAHSAAGPSPHTLRRAVKKPAPAPPKPGNPPPGHPGGQSSPGTGTSPKPSTRSPSPPQQQQQQQQQQQQQQQQQQQQQQQQQQQQQTPGMRRCSSSLPPIQAPNHPPPQPPTQPRLGEQGPEPGPTPPQTPTPPSTPPPAKQNSSQSETTQLHGTLPRPRPVPKPRNRPSVPPPPNPPGTHMGDGGLTPSVPTASRIVTDTNSRVSESLRNIFPEIHSDLASKEVPGHILLDIDNDTESTAL
uniprot
proteins
function
FUNCTION: Rho GTPase-activating protein involved in the maintenance of tight junction by regulating the activity of CDC42, thereby playing a central role in apical polarity of epithelial cells. Specifically acts as a GTPase activator for the CDC42 GTPase by converting it to an inactive GDP-bound state. The complex formed with AMOT acts by regulating the uptake of polarity proteins at tight junctions, possibly by deciding whether tight junction transmembrane proteins are recycled back to the plasma membrane or sent elsewhere (By similarity). Participates in the Ca(2+)-dependent regulation of exocytosis, possibly by catalyzing GTPase activity of Rho family proteins and by inducing the reorganization of the cortical actin filaments. Acts as a GTPase activator in vitro for RAC1. {ECO:0000250, ECO:0000269|PubMed:10967100}.
uniprot
proteins
mass_dalton
93754
uniprot
proteins
pubmed
10967100
uniprot
proteins
pubmed
12358749
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
858
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:10967100}; Peripheral membrane protein {ECO:0000269|PubMed:10967100}. Cytoplasm {ECO:0000269|PubMed:10967100}. Cell junction, tight junction {ECO:0000250}. Note=Associates with membranes and concentrates at sites of cell-cell contact. {ECO:0000250}.
uniprot
proteins