Tmem38b
entrez
52076
canonical
uniprot
Q9DAV9
canonical
ensembl
ENSMUSG00000028420
resolver
ensp
ENSMUSP00000030127
resolver
enst
ENSMUST00000030127
resolver
genesymbol
Tmem38b
resolver
genesymbol_syn
D4Ertd89e
resolver
genesymbol_syn
Mg33b
resolver
uniprot
A2AQG4
resolver
uniprot
Q3U6M4
resolver
uniprot
Q3UBM6
resolver
uniprot
Q3UWS8
resolver
uniprot_entry
TM38B_MOUSE
resolver
uniprot_sec
A2AQG4
resolver
uniprot_sec
Q3U6M4
resolver
uniprot_sec
Q3UBM6
resolver
uniprot_sec
Q3UWS8
resolver
activity_regulation
ACTIVITY REGULATION: Channel activity is activated by increased cytosolic Ca(2+) levels and blocked by luminal high Ca(2+) levels. {ECO:0000250|UniProtKB:Q6GN30}.
uniprot
proteins
amino_acid_sequence
MEYPWDDLTLAFSRTSMFPFFDIAHYLVSVMALKQRPGAVAAAWNNPLASWLSAMLHCFGGGILSCMLLAESPLKFLTNHTNILLASSIWYIVFFCPRDLVSQGYSYQPIQFLAAGMKEVTRTWKIVGGVSDANSYYRNAWIVMIVVGWARGAGGAVVTACEQLLKGDWKPEGDEWLKMSFPCKITLLGSIMFTFQHTRHLAISKHDLMFLYTIFLVTIKVTMMMTKDTAVTLTPFEDTLTRMLFGRRQQQQFSSSEKKTEVKPSSNGSASSASKRGAEPSGGAKRHAKKED
uniprot
proteins
function
FUNCTION: Intracellular monovalent cation channel required for maintenance of rapid intracellular calcium release. Acts as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. Activated by increased cytosolic Ca(2+) levels. {ECO:0000250|UniProtKB:Q6GN30}.
uniprot
proteins
mass_dalton
32640
uniprot
proteins
protein_family
TMEM38 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17611541
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
292
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:17611541}; Multi-pass membrane protein {ECO:0000269|PubMed:17611541}.
uniprot
proteins
transmembrane_region
TRANSMEM 17..34; /note="Helical;Name=1"; /evidence="ECO:0000255"; TRANSMEM 48..69; /note="Helical;Name=2"; /evidence="ECO:0000255"; TRANSMEM 83..100; /note="Helical;Name=3"; /evidence="ECO:0000255"; TRANSMEM 104..122; /note="Helical;Name=4"; /evidence="ECO:0000255"; TRANSMEM 141..158; /note="Helical;Name=5"; /evidence="ECO:0000255"; TRANSMEM 179..195; /note="Helical;Name=6"; /evidence="ECO:0000255"; TRANSMEM 207..225; /note="Helical;Name=7"; /evidence="ECO:0000255
uniprot
proteins