OSBP2
entrez
23762
canonical
uniprot
Q969R2
canonical
ensembl
ENSG00000184792
resolver
ensp
ENSP00000332576
resolver
ensp
ENSP00000385254
resolver
ensp
ENSP00000389200
resolver
ensp
ENSP00000392080
resolver
ensp
ENSP00000411052
resolver
ensp
ENSP00000438713
resolver
genesymbol
OSBP2
resolver
genesymbol_syn
KIAA1664
resolver
genesymbol_syn
ORP4
resolver
genesymbol_syn
OSBPL4
resolver
hgnc
HGNC:8504
resolver
uniprot
B0QYG1
resolver
uniprot
B4DK24
resolver
uniprot
B4DKE4
resolver
uniprot
B4DTR3
resolver
uniprot
F5H2A3
resolver
uniprot
O60396
resolver
uniprot
Q0VF99
resolver
uniprot
Q8NA37
resolver
uniprot
Q9BY96
resolver
uniprot
Q9BZF0
resolver
uniprot_entry
OSBP2_HUMAN
resolver
uniprot_sec
B0QYG1
resolver
uniprot_sec
B4DK24
resolver
uniprot_sec
B4DKE4
resolver
uniprot_sec
B4DTR3
resolver
uniprot_sec
F5H2A3
resolver
uniprot_sec
O60396
resolver
uniprot_sec
Q0VF99
resolver
uniprot_sec
Q8NA37
resolver
uniprot_sec
Q9BY96
resolver
uniprot_sec
Q9BZF0
resolver
amino_acid_sequence
MGKAAAPSRGGGCGGRSRGLSSLFTVVPCLSCHTAAPGMSASTSGSGPEPKPQPQPVPEPERGPLSEQVSEAVSEAVPRSEPVSETTSEPEPGAGQPSELLQGSRPGSESSSGVGAGPFTKAASEPLSRAVGSATFLRPESGSLPALKPLPLLRPGQAKTPLGVPMSGTGTTSSAPLALLPLDSFEGWLLKWTNYLKGYQRRWFVLGNGLLSYYRNQGEMAHTCRGTINLSTAHIDTEDSCGILLTSGARSYHLKASSEVDRQQWITALELAKAKAVRVMNTHSDDSGDDDEATTPADKSELHHTLKNLSLKLDDLSTCNDLIAKHGAALQRSLTELDGLKIPSESGEKLKVVNERATLFRITSNAMINACRDFLELAEIHSRKWQRALQYEQEQRVHLEETIEQLAKQHNSLERAFHSAPGRPANPSKSFIEGSLLTPKGEDSEEDEDTEYFDAMEDSTSFITVITEAKEDSRKAEGSTGTSSVDWSSADNVLDGASLVPKGSSKVKRRVRIPNKPNYSLNLWSIMKNCIGRELSRIPMPVNFNEPLSMLQRLTEDLEYHHLLDKAVHCTSSVEQMCLVAAFSVSSYSTTVHRIAKPFNPMLGETFELDRLDDMGLRSLCEQVSHHPPSAAHYVFSKHGWSLWQEITISSKFRGKYISIMPLGAIHLEFQASGNHYVWRKSTSTVHNIIVGKLWIDQSGDIEIVNHKTNDRCQLKFLPYSYFSKEAARKVTGVVSDSQGKAHYVLSGSWDEQMECSKVMHSSPSSPSSDGKQKTVYQTLSAKLLWKKYPLPENAENMYYFSELALTLNEHEEGVAPTDSRLRPDQRLMEKGRWDEANTEKQRLEEKQRLSRRRRLEACGPGSSCSSEEEKEADAYTPLWFEKRLDPLTGEMACVYKGGYWEAKEKQDWHMCPNIF
uniprot
proteins
function
FUNCTION: Mediates the bidirectional lipid exchange between intracellular compartments and the plasma membrane, delivering cholesterol to the plasma membrane while transferring PI(4,5)P(2) to internal organelles, thereby modulating membrane lipid composition and associated signaling pathways (PubMed:30581148, PubMed:32914503). Binds 7-ketocholesterol (PubMed:11278871). Acts during spermatid development where its function is required prior to the removal of cytoplasm from the sperm head (By similarity). {ECO:0000250|UniProtKB:Q8CF21, ECO:0000269|PubMed:11278871, ECO:0000269|PubMed:30581148, ECO:0000269|PubMed:32914503}.
uniprot
proteins
mass_dalton
101266
uniprot
proteins
protein_family
OSBP family
uniprot
proteins
pubmed
10591208
uniprot
proteins
pubmed
11258795
uniprot
proteins
pubmed
11278871
uniprot
proteins
pubmed
11483621
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
30581148
uniprot
proteins
pubmed
32914503
uniprot
proteins
sequence_length
916
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:11278871}; Peripheral membrane protein {ECO:0000269|PubMed:11278871}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:Q8CF21}. Note=Localizes to the equatorial segment of the acrosome. {ECO:0000250|UniProtKB:Q8CF21}.
uniprot
proteins