Fosb
entrez
100360880
canonical
uniprot
D3ZLB7
canonical
ensembl
ENSRNOG00000046667
resolver
ensembl
ENSRNOG00055032941
resolver
ensembl
ENSRNOG00060032929
resolver
ensembl
ENSRNOG00065031402
resolver
ensp
ENSRNOP00000065427
resolver
ensp
ENSRNOP00000091996
resolver
ensp
ENSRNOP00055047082
resolver
ensp
ENSRNOP00060047180
resolver
ensp
ENSRNOP00065044594
resolver
enst
ENSRNOT00000072149
resolver
enst
ENSRNOT00055056986
resolver
enst
ENSRNOT00060057100
resolver
enst
ENSRNOT00065054191
resolver
genesymbol
Fosb
resolver
uniprot_entry
FOSB_RAT
resolver
amino_acid_sequence
MFQAFPGDYDSGSRCSSSPSAESQYLSSVDSFGSPPTAAASQECAGLGEMPGSFVPTVTAITTSQDLQWLVQPTLISSMAQSQGQPLASQPPAVDPYDMPGTSYSTPGLSAYSTGGASGSGGPSTSTSTSGPVSARPARARPRRPREETLTPEEEEKRRVRRERNKLAAAKCRNRRRELTDRLQAETDQLEEEKAELESEIAELQKEKERLEFVLVAHKPGCKIPYEEGPGPGPLAEVRDLPGSTSAKEDGFGWLLPPPPPPPLPFQSSRDAPPNLTASLFTHSEVQVLGDPFPVVSPSYTSSFVLTCPEVSAFAGSQRTSGSEQPSDPLNSPSLLAL
uniprot
proteins
function
FUNCTION: Heterodimerizes with proteins of the JUN family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to an AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing their transcriptional activity (By similarity). Exhibits transactivation activity in vitro (By similarity). As part of the AP-1 complex, facilitates enhancer selection together with cell-type-specific transcription factors by collaboratively binding to nucleosomal enhancers and recruiting the SWI/SNF (BAF) chromatin remodeling complex to establish accessible chromatin (By similarity). Together with JUN, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway (By similarity). Involved in the display of nurturing behavior towards newborns (By similarity). May play a role in neurogenesis in the hippocampus and in learning and memory-related tasks by regulating the expression of various genes involved in neurogenesis, depression and epilepsy (By similarity). Implicated in behavioral responses related to morphine reward and spatial memory (By similarity). {ECO:0000250|UniProtKB:P13346, ECO:0000250|UniProtKB:P53539}.
uniprot
proteins
mass_dalton
35979
uniprot
proteins
post_translational_modification
PTM: Phosphorylated; phosphorylation is induced by chronic electroconvulsive seizure (ECS) treatment. {ECO:0000269|PubMed:16687504}.
uniprot
proteins
protein_family
BZIP family
uniprot
proteins
protein_family
Fos subfamily
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15632090
uniprot
proteins
pubmed
16687504
uniprot
proteins
pubmed
26446228
uniprot
proteins
sequence_length
338
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P13346}.
uniprot
proteins