Ganab
entrez
14376
canonical
uniprot
Q8BHN3
canonical
ensembl
ENSMUSG00000071650
resolver
ensp
ENSMUSP00000093965
resolver
ensp
ENSMUSP00000158122
resolver
genesymbol
Ganab
resolver
genesymbol_syn
G2an
resolver
genesymbol_syn
Kiaa0088
resolver
uniprot
A1A4T2
resolver
uniprot
O08794
resolver
uniprot
Q149A6
resolver
uniprot
Q80U81
resolver
uniprot
Q9CS53
resolver
uniprot_entry
A1A4T2_MOUSE
resolver
uniprot_entry
GANAB_MOUSE
resolver
uniprot_sec
O08794
resolver
uniprot_sec
Q149A6
resolver
uniprot_sec
Q80U81
resolver
uniprot_sec
Q9CS53
resolver
amino_acid_sequence
MAAIAAVAARRRRSWLSLVLAYLGVCLGITLAVDRSNFKTCDESSFCKRQRSIRPGLSPYRALLDTLQLGPDALTVHLIHEVTKVLLVLELQGLQKNMTRIRIDELEPRRPRYRVPDVLVADPPTARLSVSGRDDNSVELTVAEGPYKIILTAQPFRLDLLEDRSLLLSVNARGLMAFEHQRAPRVPQESKDPAEGNGAQPEATPGDGDKPEETQEKAEKDEPGAWEETFKTHSDSKPYGPTSVGLDFSLPGMEHVYGIPEHADSLRLKVTEGGEPYRLYNLDVFQYELNNPMALYGSVPVLLAHSFHRDLGIFWLNAAETWVDISSNTAGKTLFGKMLDYLQGSGETPQTDIRWMSESGIIDVFLMLGPSVFDVFRQYASLTGTQALPPLFSLGYHQSRWNYRDEADVLEVDQGFDDHNMPCDVIWLDIEHADGKRYFTWDPTRFPQPLNMLEHLASKRRKLVAIVDPHIKVDSGYRVHEELRNHGLYVKTRDGSDYEGWCWPGSASYPDFTNPRMRAWWSNMFSFDNYEGSAPNLYVWNDMNEPSVFNGPEVTMLKDAVHYGGWEHRDIHNIYGLYVHMATADGLIQRSGGIERPFVLSRAFFSGSQRFGAVWTGDNTAEWDHLKISIPMCLSLALVGLSFCGADVGGFFKNPEPELLVRWYQMGAYQPFFRAHAHLDTGRREPWLLASQYQDAIRDALFQRYSLLPFWYTLFYQAHKEGFPVMRPLWVQYPEDMSTFSIEDQFMLGDALLIHPVSDAGAHGVQVYLPGQEEVWYDIQSYQKHHGPQTLYLPVTLSSIPVFQRGGTIVPRWMRVRRSSDCMKDDPITLFVALSPQGTAQGELFLDDGHTFNYQTRHEFLLRRFSFSGSTLVSSSADPKGHLETPIWIERVVIMGAGKPAAVVLQTKGSPESRLSFQHDPETSVLILRKPGVSVASDWSIHLR
uniprot
proteins
ec_number
3.2.1.207
uniprot
proteins
function
FUNCTION: Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:27462106). Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia (PubMed:28375157). {ECO:0000269|PubMed:27462106, ECO:0000269|PubMed:28375157}.
uniprot
proteins
mass_dalton
106911
uniprot
proteins
mutagenesis
MUTAGEN 542; /note="D->E,N: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:27462106"; MUTAGEN 618; /note="D->N: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:27462106"; MUTAGEN 818; /note="R->E: Disrupts interaction with PRKCSH. Nearly abolishes enzyme activity."; /evidence="ECO:0000269|PubMed:27462106
uniprot
proteins
pathway_participation
PATHWAY: Glycan metabolism; N-glycan metabolism. {ECO:0000269|PubMed:27462106}.
uniprot
proteins
protein_family
Glycosyl hydrolase 31 family
uniprot
proteins
pubmed
10921916
uniprot
proteins
pubmed
12693553
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
27462106
uniprot
proteins
pubmed
28375157
uniprot
proteins
pubmed
9148925
uniprot
proteins
sequence_length
944
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum {ECO:0000250|UniProtKB:Q14697}. Golgi apparatus {ECO:0000250|UniProtKB:P79403}. Melanosome {ECO:0000250|UniProtKB:Q14697}.
uniprot
proteins