TRIM10
entrez
10107
canonical
uniprot
Q9UDY6
canonical
ensembl
ENSG00000137394
resolver
ensembl
ENSG00000204613
resolver
ensembl
ENSG00000227472
resolver
ensembl
ENSG00000229346
resolver
ensembl
ENSG00000229381
resolver
ensembl
ENSG00000235025
resolver
ensembl
ENSG00000237192
resolver
ensembl
ENSG00000237703
resolver
ensp
ENSP00000365894
resolver
ensp
ENSP00000397073
resolver
genesymbol
TRIM10
resolver
genesymbol_syn
RFB30
resolver
genesymbol_syn
RNF9
resolver
hgnc
HGNC:10072
resolver
uniprot
A6NF84
resolver
uniprot
Q5SRJ5
resolver
uniprot
Q5SRK8
resolver
uniprot
Q86Z08
resolver
uniprot
Q96QB6
resolver
uniprot
Q9C023
resolver
uniprot
Q9C024
resolver
uniprot_entry
TRI10_HUMAN
resolver
uniprot_sec
A6NF84
resolver
uniprot_sec
Q5SRJ5
resolver
uniprot_sec
Q5SRK8
resolver
uniprot_sec
Q86Z08
resolver
uniprot_sec
Q96QB6
resolver
uniprot_sec
Q9C023
resolver
uniprot_sec
Q9C024
resolver
amino_acid_sequence
MASAASVTSLADEVNCPICQGTLREPVTIDCGHNFCRACLTRYCEIPGPDLEESPTCPLCKEPFRPGSFRPNWQLANVVENIERLQLVSTLGLGEEDVCQEHGEKIYFFCEDDEMQLCVVCREAGEHATHTMRFLEDAAAPYREQIHKCLKCLRKEREEIQEIQSRENKRMQVLLTQVSTKRQQVISEFAHLRKFLEEQQSILLAQLESQDGDILRQRDEFDLLVAGEICRFSALIEELEEKNERPARELLTDIRSTLIRCETRKCRKPVAVSPELGQRIRDFPQQALPLQREMKMFLEKLCFELDYEPAHISLDPQTSHPKLLLSEDHQRAQFSYKWQNSPDNPQRFDRATCVLAHTGITGGRHTWVVSIDLAHGGSCTVGVVSEDVQRKGELRLRPEEGVWAVRLAWGFVSALGSFPTRLTLKEQPRQVRVSLDYEVGWVTFTNAVTREPIYTFTASFTRKVIPFFGLWGRGSSFSLSS
uniprot
proteins
ec_number
2.3.2.27
uniprot
proteins
function
FUNCTION: E3 ubiquitin-protein ligase that plays an essential role in the differentiation and survival of terminal erythroid cells (By similarity). May directly bind to PTEN and promote its ubiquitination, resulting in its proteasomal degradation and activation of hypertrophic signaling (By similarity). Acts as a positive regulator of cGAS-STING signaling by mediating 'Lys-27'- and 'Lys-29'-linked polyubiquitination of STING1, promoting STING1 activation (PubMed:36972172). In addition, plays a role in immune response regulation by repressing the phosphorylation of STAT1 and STAT2 in the interferon/JAK/STAT signaling pathway independent of its E3 ligase activity (PubMed:33811647). Mechanistically, interacts with the intracellular domain of IFNAR1 and thereby inhibits the association between TYK2 and IFNAR1 (PubMed:33811647). {ECO:0000250|UniProtKB:Q9WUH5, ECO:0000269|PubMed:33811647, ECO:0000269|PubMed:36972172}.
uniprot
proteins
mass_dalton
55037
uniprot
proteins
mutagenesis
MUTAGEN 36..39; /note="CRAC->ARAA: Abolished 3 ubiquitin-protein ligase activity."; /evidence="ECO:0000269|PubMed:36972172
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:36972172, ECO:0000269|PubMed:40821731}.
uniprot
proteins
protein_family
TRIM/RBCC family
uniprot
proteins
pubmed
11331580
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16702430
uniprot
proteins
pubmed
33811647
uniprot
proteins
pubmed
36972172
uniprot
proteins
pubmed
40821731
uniprot
proteins
pubmed
9271628
uniprot
proteins
sequence_length
481
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:11331580, ECO:0000269|PubMed:33811647}.
uniprot
proteins