Ackr2
entrez
59289
canonical
uniprot
O08707
canonical
ensembl
ENSMUSG00000044534
resolver
ensp
ENSMUSP00000050119
resolver
ensp
ENSMUSP00000148966
resolver
ensp
ENSMUSP00000173829
resolver
enst
ENSMUST00000050327
resolver
enst
ENSMUST00000214340
resolver
genesymbol
Ackr2
resolver
genesymbol_syn
Ccbp2
resolver
genesymbol_syn
D6
resolver
uniprot
Q8CEG1
resolver
uniprot_entry
ACKR2_MOUSE
resolver
uniprot_sec
Q8CEG1
resolver
amino_acid_sequence
MPTVASPLPLTTVGSENSSSIYDYDYLDDMTILVCRKDEVLSFGRVFLPVVYSLIFVLGLAGNLLLLVVLLHSAPRRRTMELYLLNLAVSNLLFVVTMPFWAISVAWHWVFGSFLCKVISTLYSINFYCGIFFITCMSLDKYLEIVHAQPLHRPKAQFRNLLLIVMVWITSLAISVPEMVFVQIHQTLDGVWHCYADFGGHATIWKLYLRFQLNLLGFLLPLLAMIFFYSRIGCVLVRLRPPGQGRALRMAAALVIVFFMLWFPYNLTLFLHSLLDLHVFGNCEISHRLDYTLQVTESLAFSHCCFTPVLYAFCSHRFRRYLKAFLSVMLRWHQAPGTPSSNHSESSRVTAQEDVVSMNDLGERQSEDSLNKGEMGNT
uniprot
proteins
function
FUNCTION: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs. {ECO:0000269|PubMed:22651933}.
uniprot
proteins
mass_dalton
43207
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine residues in the C-terminal cytoplasmic tail. {ECO:0000250|UniProtKB:O00590}.
uniprot
proteins
protein_family
Atypical chemokine receptor subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
22651933
uniprot
proteins
pubmed
23125030
uniprot
proteins
pubmed
9139699
uniprot
proteins
sequence_length
378
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome {ECO:0000250|UniProtKB:O00590}. Recycling endosome {ECO:0000250|UniProtKB:O00590}. Cell membrane {ECO:0000250|UniProtKB:O00590}; Multi-pass membrane protein {ECO:0000255}. Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via clathrin-coated pits. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane. {ECO:0000250|UniProtKB:O00590}.
uniprot
proteins
transmembrane_region
TRANSMEM 50..70; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 92..112; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 118..139; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 162..182; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 217..237; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 250..270; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 293..313; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins