Magoh
entrez
17149
canonical
uniprot
P61327
canonical
ensembl
ENSMUSG00000028609
resolver
ensp
ENSMUSP00000030348
resolver
enst
ENSMUST00000030348
resolver
genesymbol
Magoh
resolver
uniprot
A2A8E0
resolver
uniprot
O35169
resolver
uniprot
P50606
resolver
uniprot_entry
MGN_MOUSE
resolver
uniprot_sec
A2A8E0
resolver
uniprot_sec
O35169
resolver
uniprot_sec
P50606
resolver
amino_acid_sequence
MESDFYLRYYVGHKGKFGHEFLEFEFRPDGKLRYANNSNYKNDVMIRKEAYVHKSVMEELKRIIDDSEITKEDDALWPPPDRVGRQELEIVIGDEHISFTTSKIGSLIDVNQSKDPEGLRVFYYLVQDLKCLVFSLIGLHFKIKPI
uniprot
proteins
function
FUNCTION: Required for pre-mRNA splicing as component of the spliceosome. Plays a redundant role with MAGOHB as core component of the exon junction complex (EJC) and in the nonsense-mediated decay (NMD) pathway. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S pre-initiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms; the function is different from the established EJC assembly. {ECO:0000250|UniProtKB:P61326}.
uniprot
proteins
mass_dalton
17164
uniprot
proteins
protein_family
Mago nashi family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
23917022
uniprot
proteins
pubmed
9272960
uniprot
proteins
pubmed
9479507
uniprot
proteins
sequence_length
146
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P61326}. Nucleus speckle {ECO:0000250|UniProtKB:P61326}. Cytoplasm {ECO:0000250|UniProtKB:P61326}. Note=Detected in granule-like structures in the dendroplasm. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles. {ECO:0000250|UniProtKB:P61326, ECO:0000250|UniProtKB:Q27W02}.
uniprot
proteins