Actn1
entrez
109711
canonical
uniprot
Q7TPR4
canonical
ensembl
ENSMUSG00000015143
resolver
ensp
ENSMUSP00000021554
resolver
ensp
ENSMUSP00000127176
resolver
ensp
ENSMUSP00000313038
resolver
enst
ENSMUST00000021554
resolver
enst
ENSMUST00000167327
resolver
genesymbol
Actn1
resolver
genesymbol_syn
Actn1a
resolver
uniprot
A1BN54
resolver
uniprot
F6SKX1
resolver
uniprot_entry
A1BN54_MOUSE
resolver
uniprot_entry
ACTN1_MOUSE
resolver
uniprot_entry
F6SKX1_MOUSE
resolver
amino_acid_sequence
MDHYDSQQTNDYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDVAERFLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQQKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGCLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEIKALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALTQKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTAHEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQLVPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSHLRQYEKSIVNYKPKIDQLECDHQLIQEALIFDNKHTNYNMEHIRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITEDELRRELPPDQAEYCIARMAPYAGPDSVPGALDYMSFSTALYGESDL
uniprot
proteins
function
FUNCTION: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation. {ECO:0000250|UniProtKB:P12814}.
uniprot
proteins
mass_dalton
103068
uniprot
proteins
mutagenesis
MUTAGEN 32; /note="Q->K: Shows less organization of the circumferential actin-filament network compared to controls."; /evidence="ECO:0000269|PubMed:23434115"; MUTAGEN 105; /note="V->I: Shows less organization of the circumferential actin-filament network compared to controls."; /evidence="ECO:0000269|PubMed:23434115
uniprot
proteins
protein_family
Alpha-actinin family
uniprot
proteins
pubmed
11114196
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17298598
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23100251
uniprot
proteins
pubmed
23434115
uniprot
proteins
sequence_length
892
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23100251}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:11114196}. Cell membrane {ECO:0000250|UniProtKB:P12814}. Cell junction {ECO:0000250|UniProtKB:Q9Z1P2}. Cell projection, ruffle {ECO:0000269|PubMed:17298598}. Note=Colocalizes with MYOZ2 and PPP3CA at the Z-line of heart and skeletal muscle (PubMed:11114196). Colocalizes with PSD in membrane ruffles and central reticular structures (PubMed:17298598). {ECO:0000269|PubMed:11114196, ECO:0000269|PubMed:17298598}.
uniprot
proteins