Alx4
entrez
11695
canonical
uniprot
O35137
canonical
ensembl
ENSMUSG00000040310
resolver
ensp
ENSMUSP00000047962
resolver
enst
ENSMUST00000042078
resolver
genesymbol
Alx4
resolver
uniprot_entry
ALX4_MOUSE
resolver
amino_acid_sequence
MNAETCVSYCESPAAAMDAYYSPVSQSREGSSPFRGFPGGDKFGTTFLSAGAKGQGFGDAKSRARYGAGQQDLAAPLESSSGARGSFNKFQPQPPTPQPPPAPPAPPAHLYLQRGACKTPPDGSLKLQEGSGGHNAALQVPCYAKESNLGEPELPPDSEPVGMDNSYLSVKETGAKGPQDRASAEIPSPLEKTDSESNKGKKRRNRTTFTSYQLEELEKVFQKTHYPDVYAREQLAMRTDLTEARVQVWFQNRRAKWRKRERFGQMQQVRTHFSTAYELPLLTRAENYAQIQNPSWIGNNGAASPVPACVVPCDPVPACMSPHAHPPGSGASSVSDFLSVSGAGSHVGQTHMGSLFGAAGISPGLNGYEMNGEPDRKTSSIAALRMKAKEHSAAISWAT
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Alx4 are the cause of Strong luxoid (lst) phenotype. At heterozygosity lst is characterized by preaxial abnormalities of the hindfeet and, very rarely, of the forefeet. Homozygotes show preaxial polydactyly of all four limbs, reductions and duplications of the radius, absence of the tibia, craniofacial defects, reduction of the pubis, and dorsal alopecia. {ECO:0000269|PubMed:9636085}.
uniprot
proteins
function
FUNCTION: Transcription factor involved in skull and limb development.
uniprot
proteins
mass_dalton
42763
uniprot
proteins
protein_family
Paired homeobox family
uniprot
proteins
pubmed
9426253
uniprot
proteins
pubmed
9636085
uniprot
proteins
sequence_length
399
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins