DPH7
entrez
92715
canonical
uniprot
Q9BTV6
canonical
ensembl
ENSG00000148399
resolver
ensp
ENSP00000277540
resolver
ensp
ENSP00000542948
resolver
ensp
ENSP00000675923
resolver
ensp
ENSP00000709272
resolver
ensp
ENSP00000709279
resolver
enst
ENST00000277540
resolver
genesymbol
DPH7
resolver
genesymbol_syn
C9orf112
resolver
genesymbol_syn
WDR85
resolver
hgnc
HGNC:25199
resolver
uniprot
Q96AB7
resolver
uniprot_entry
DPH7_HUMAN
resolver
uniprot_sec
Q96AB7
resolver
amino_acid_sequence
MMGCFALQTVDTELTADSVEWCPLQGCRHLLACGTYQLRRPEDRPAGPQNKGGMEVKEPQVRLGRLFLYSFNDNNSIHPLVEVQRKDTSAILDMKWCHIPVAGHALLGLADASGSIQLLRLVESEKSHVLEPLSSLALEEQCLALSLDWSTGKTGRAGDQPLKIISSDSTGQLHLLMVNETRPRLQKVASWQAHQFEAWIAAFNYWHPEIVYSGGDDGLLRGWDTRVPGKFLFTSKRHTMGVCSIQSSPHREHILATGSYDEHILLWDTRNMKQPLADTPVQGGVWRIKWHPFHHHLLLAACMHSGFKILNCQKAMEERQEATVLTSHTLPDSLVYGADWSWLLFRSLQRAPSWSFPSNLGTKTADLKGASELPTPCHECREDNDGEGHARPQSGMKPLTEGMRKNGTWLQATAATTRDCGVNPEEADSAFSLLATCSFYDHALHLWEWEGN
uniprot
proteins
ec_number
3.1.1.97
uniprot
proteins
function
FUNCTION: Catalyzes the demethylation of diphthine methyl ester to form diphthine, an intermediate diphthamide biosynthesis, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2) which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta). {ECO:0000250|UniProtKB:P38332, ECO:0000269|PubMed:19965467, ECO:0000269|PubMed:23486472}.
uniprot
proteins
mass_dalton
50575
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; peptidyl-diphthamide biosynthesis.
uniprot
proteins
protein_family
DPH7 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19965467
uniprot
proteins
pubmed
21750715
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
23486472
uniprot
proteins
sequence_length
452
uniprot
proteins