Pacrg
entrez
69310
canonical
uniprot
Q9DAK2
canonical
ensembl
ENSMUSG00000037196
resolver
ensp
ENSMUSP00000044376
resolver
enst
ENSMUST00000041463
resolver
genesymbol
Pacrg
resolver
uniprot
Q0VB91
resolver
uniprot
Q3UXK4
resolver
uniprot
Q7TPF9
resolver
uniprot
Q8CG20
resolver
uniprot_entry
PACRG_MOUSE
resolver
uniprot_entry
Q0VB91_MOUSE
resolver
uniprot_entry
Q3UXK4_MOUSE
resolver
uniprot_sec
Q7TPF9
resolver
uniprot_sec
Q8CG20
resolver
amino_acid_sequence
MPKRTKLLPQQTFQVHQPRSLVSEGFTVKAMMKNSVVRGPPVAGAFKERPAKPTTFRKCYERGDFPIALEHDSKGNKIAWKVEIEKLDYHHYLPLFFDGLSEMTFPYEFFARRGIHDMLEHGGNKILPVIPQLIIPIKNALNLRNRQIICVTLKVLQHLVVSSEMVGEALLPYYRQILPILNIFKNMNVNSGDGIDYSQQKRENIGDLIQETLEAFERYGGEDAFINIKYMVPTYESCLLN
uniprot
proteins
function
FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:37295417, PubMed:37865089, PubMed:37989994). Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin) (By similarity). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited (By similarity). May play an important role in the formation of Lewy bodies and protection of dopaminergic neurons against Parkinson disease (By similarity). {ECO:0000250|UniProtKB:A5PK71, ECO:0000250|UniProtKB:Q96M98, ECO:0000269|PubMed:37295417, ECO:0000269|PubMed:37865089, ECO:0000269|PubMed:37989994}.
uniprot
proteins
mass_dalton
27726
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19805151
uniprot
proteins
pubmed
37295417
uniprot
proteins
pubmed
37865089
uniprot
proteins
pubmed
37989994
uniprot
proteins
sequence_length
241
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000250|UniProtKB:A5PK71}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000269|PubMed:37295417, ECO:0000269|PubMed:37865089, ECO:0000269|PubMed:37989994}.
uniprot
proteins