RSPH3
entrez
83861
canonical
uniprot
Q86UC2
canonical
ensembl
ENSG00000130363
resolver
ensp
ENSP00000356036
resolver
genesymbol
RSPH3
resolver
genesymbol_syn
RSHL2
resolver
genesymbol_syn
RSP3
resolver
hgnc
HGNC:21054
resolver
uniprot
Q96LQ5
resolver
uniprot
Q96LX2
resolver
uniprot
Q9BX75
resolver
uniprot_entry
RSPH3_HUMAN
resolver
uniprot_sec
Q96LQ5
resolver
uniprot_sec
Q96LX2
resolver
uniprot_sec
Q9BX75
resolver
amino_acid_sequence
MTVKPAKAASLARNLAKRRRTYLGGAAGRSQEPEVPCAAVLPGKPGDRNCPEFPPPDRTLGCWATDAAPAAGLCGAGSEPSIAPTSCAGNLPSRPPPLLSPLLASRNPCPWHYLHLSGSHNTLAPTCFKAKLHRKRGSQPPDMASALTDRTSRAPSTYTYTSRPRALPCQRSRYRDSLTQPDEEPMHYGNIMYDRRVIRGNTYALQTGPLLGRPDSLELQRQREARKRALARKQAQEQLRPQTPEPVEGRKHVDVQTELYLEEIADRIIEVDMECQTDAFLDRPPTPLFIPAKTGKDVATQILEGELFDFDLEVKPVLEVLVGKTIEQSLLEVMEEEELANLRASQREYEELRNSERAEVQRLEEQERRHREEKERRKKQQWEIMHKHNETSQKIAARAFAQRYLADLLPSVFGSLRDSGYFYDPIERDIEIGFLPWLMNEVEKTMEYSMVGRTVLDMLIREVVEKRLCMYEHGEDTHQSPEPEDEPGGPGAMTESLEASEFLEQSMSQTRELLLDGGYLQRTTYDRRSSQERKFMEERELLGQDEETAMRKSLGEEELS
uniprot
proteins
disease_involvement
DISEASE: Ciliary dyskinesia, primary, 32 (CILD32) [MIM:616481]: A disorder characterized by abnormalities of motile cilia. Respiratory infections leading to chronic inflammation and bronchiectasis are recurrent, due to defects in the respiratory cilia. {ECO:0000269|PubMed:26073779}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia (By similarity). Functions as a protein kinase A-anchoring protein that scaffolds the cAMP-dependent protein kinase holoenzyme. May serve as a point of convergence for MAPK and PKA signaling in cilia (PubMed:19684019). {ECO:0000250|UniProtKB:Q9DA80, ECO:0000269|PubMed:19684019}.
uniprot
proteins
mass_dalton
63687
uniprot
proteins
protein_family
Flagellar radial spoke RSP3 family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19684019
uniprot
proteins
pubmed
26073779
uniprot
proteins
pubmed
27120127
uniprot
proteins
pubmed
36355624
uniprot
proteins
pubmed
37804054
uniprot
proteins
sequence_length
560
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269|PubMed:27120127}. Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000305}.
uniprot
proteins