Kndc1
entrez
76484
canonical
uniprot
Q0KK55
canonical
ensembl
ENSMUSG00000066129
resolver
ensp
ENSMUSP00000050586
resolver
genesymbol
Kndc1
resolver
genesymbol_syn
Kiaa1768
resolver
genesymbol_syn
Rasgef2
resolver
genesymbol_syn
Vkind
resolver
uniprot
Q0KK50
resolver
uniprot
Q3TF27
resolver
uniprot
Q3UGX9
resolver
uniprot
Q3UGZ3
resolver
uniprot
Q3UHK4
resolver
uniprot
Q7TNH0
resolver
uniprot
Q8BTH5
resolver
uniprot
Q8BXJ3
resolver
uniprot_entry
KNDC1_MOUSE
resolver
uniprot_sec
Q0KK50
resolver
uniprot_sec
Q3TF27
resolver
uniprot_sec
Q3UGX9
resolver
uniprot_sec
Q3UGZ3
resolver
uniprot_sec
Q3UHK4
resolver
uniprot_sec
Q7TNH0
resolver
uniprot_sec
Q8BTH5
resolver
uniprot_sec
Q8BXJ3
resolver
amino_acid_sequence
MQAMDPASRGFYEEDGKDLDFYDFEPLPTLPEDEENVSLADILSLRDRGLSEQEAWAVCLECSLSMRSVAHAAIFQTLCITPDTLAFNTSGNVCFMEQLSDDPEGAFVPPEFDLTGNTFEAHIYSLGATLKAALEYVPEPELEPKLSTDLEGLLSQMQAEDPRERPDLASIIALCEEKMQPVSSCRLCRSLSAIGRRVLSIESFGAFQELSENTWRGRPAPRNVGPKKMPGDLSTDPEALFPSKGLLQPPASRDAEQEAGQRPRAPSPKPLLSAPVRNGENPGQEGLADLVLDARCPLGELDRDNLRRSRLKKAQTFPRLLQESTETSTLCLSLNGSRNQLAISEFFPPDPRKLFLEGKNGLSGFKTQSKSRLWPEQEPGVQLDKTPGAGRNPHRSPGASGQLEASSPSQGSVEYKPSPSPVDAGDSDHEGHIPRSEEKIPEESRQPGSTATEQSLSLKDLLSKLGRPFREYELWALCLSCLSTLQTHKEHPAHLCLDNVLVAEDGTVFFGPPPANGAYNSLFLAPEVSEEKLVTEKASVYCVAAVLWTAAKFSVPRDHKLALPRRLKTLLLDMARRHASERPSAAEAIKVCSSYLLQRGMDSSKILAHLRASTCKVHPEEETIGLQNAFSVVELKSTTAPAPESSPGFLQVSNDTKLVAVPGPVPGLPPCCKEACELPAAFTSEATHFKPIVLAQDASVTRDQLALPSESNEKPKEGSGHLDREGTRKQAALELVEATDLKMSNQLSPGPELQGATPDPDGDSGSPSSATECSCPHGPALVTQQKGTSGTPSSPASSLPPEHRPDGEGPLGTTVLPGPTSASQGSRHPCKPPRGKAAASPSSPRGSDGHPEKPRPADRKLCPSSVDTSSPPKMTACPSLQEAMRLIQEEFAFDGYMDNGLEALIMGEYIYALKDLTFATFCGAISEKFCDLYWDEQLLKNLFKVVNGPASPSESTSEEPGSQPEHSPSRCSLSSKRPSLHGLGKEKPATTWGSGGPCSPTALSDIDSDTLSQGNFEVGFRSQKSIKVTREQQPEAEVGGQPGPSQDSTSHASDTVARLARSEDGGPAGSPGASDFQNCSPGWSSAFYEADCFGADVYNYVKDLERQKTNGHTELEAQSPELEQQLMIEKRNYRKTLKFYQKLLQKEKRNKGSEVRTMLSKLRGQLDEMKSKVQFLSLVKKYLQVMYAERWGLEPCALPVIVNIAAAPCDTLDFSPLDESSSLIFYNVNKHPGSGRQKKARILQAGTPLGLMAYLYSSDAFLEGYVQQFLYTFRYFCTPHDFLHFLLDRISSTLSRAHQDPTSTFTKIYRRSLCVLQAWVEDCYTVDFIRNAGLLGQLEDFISSKILPLDGTAEHLLALLEVGTERRADSASRGADLEDPKEAEEDTRPFNALCKRFSEDGITRKSFSWRLPRGNGLVLPHHKERQYTIASALPKPCFFEDFYGPYAKASEKGPYFLTEYSTNQLFTQLTLLQQELFQKCHPVHFLNSRALGVMDKSAAIPKASSSESLSAKTCSLFLPNYVQDKYLLQLLRNADDVSTWVAAEIVTSHTSKLQVNLLSKFLLIAKSCYEQRNFATAMQILGGLEHLAVRQSPAWRILPAKIAEVMEELKAVEVFLKSDSLCLMEGRRFRAQPTLPSAHLLAMHIQQLETGGFTMTNGAHRWSKLRNIAKVASQVHAFQENPYTFSPDPKLQAHLKQRIARFSGADVSILAADNRANFHQIPGEKHSRKIQDKLRRMKATFQ
uniprot
proteins
function
FUNCTION: RAS-Guanine nucleotide exchange factor (GEF) that controls the negative regulation of neuronal dendrite growth by mediating a signaling pathway linking RAS and MAP2 (PubMed:17984326, PubMed:21385318). May be involved in cellular senescence (By similarity). {ECO:0000250|UniProtKB:Q76NI1, ECO:0000269|PubMed:17984326, ECO:0000269|PubMed:21385318}.
uniprot
proteins
mass_dalton
191313
uniprot
proteins
mutagenesis
MUTAGEN 461; /note="L->A: Abolishes interaction with MAP2."; /evidence="ECO:0000269|PubMed:21385318"; MUTAGEN 474; /note="L->A: Abolishes interaction with MAP2."; /evidence="ECO:0000269|PubMed:21385318"; MUTAGEN 477; /note="L->A: Abolishes interaction with MAP2."; /evidence="ECO:0000269|PubMed:21385318"; MUTAGEN 482; /note="L->A: No effect on interaction with MAP2."; /evidence="ECO:0000269|PubMed:21385318"; MUTAGEN 485; /note="L->A: No effect on interaction with MAP2."; /evidence="ECO:0000269|PubMed:21385318
uniprot
proteins
pubmed
16099729
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16807365
uniprot
proteins
pubmed
17984326
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21385318
uniprot
proteins
sequence_length
1742
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, dendrite {ECO:0000269|PubMed:17984326}. Perikaryon {ECO:0000269|PubMed:17984326}.
uniprot
proteins