Gfpt1
entrez
297417
canonical
uniprot
P82808
canonical
ensembl
ENSRNOG00000018507
resolver
ensp
ENSRNOP00000075660
resolver
enst
ENSRNOT00000090827
resolver
genesymbol
Gfpt1
resolver
uniprot
A0A0G2KB56
resolver
uniprot
Q5XI08
resolver
uniprot_entry
A0A0G2KB56_RAT
resolver
uniprot_entry
GFPT1_RAT
resolver
uniprot_sec
Q5XI08
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by 4,4'-dithiodipyridine. {ECO:0000269|PubMed:10898949}.
uniprot
proteins
amino_acid_sequence
MCGIFAYLNYHVPRTRREILETLIKGLQRLEYRGYDSAGVGLDGGNDKDWEANACKIQLIKKKGKVKALDEEVHKQQDMDLDIEFDVHLGIAHTRWATHGEPSPVNSHPQRSDKNNEFIVIHNGIITNYKDLKKFLESKGYDFESETDTETIAKLVKYMYDNWESQDVSFTTLVERVIQQLEGAFALVFKSVHFPGQAVGTRRGSPLLIGVRSEHKLSTDHIPILYRTGKDKKGSCGLSRVDSTTCLFPVEEKAVEYYFASDASAVIEHTNRVIFLEDDDVAAVVDGRLSIHRIKRTARDHPGRAVQTLQMELQQIMKGNFSSFMQKEIFEQPESVVNTMRGRVNFDDYTVNLGGLKDHIKEIQRCRRLILIACGTSYHAGMATRQVLEELTELPVMVELASDFLDRNTPVFRDDVCFFISQSGETADTLMGLRYCKERGALTVGITNTVGSSISRETDCGVHINAGPEIGVASTKAYTSQFVSLVMFALMMCDDRISMQERRKEIMLGLKRLPDLIKEVLSMDDEIQKLATELYHQKSVLIMGRGYHYATCLEGALKIKEITYMHSEGILAGELKHGPLALVDKLMPVIMIIMRDHTYAKCQNALQQVVARQGRPVVICDKEDTETIKNTKRTIKVPHSVDCLQGILSVIPLQLLAFHLAVLRGYDVDFPRNLAKSVTVE
uniprot
proteins
ec_number
2.6.1.16
uniprot
proteins
function
FUNCTION: Rate-limiting enzyme of the hexosamine biosynthetic pathway (HBP) that catalyzes the formation of glucosamine-6-phosphate from fructose-6-phosphate and glutamine, thereby controlling the flux of glucose into this pathway (PubMed:10898949). Inhibited by UDP-N-acetylglucosamine (UDP-GlcNAc) through a feedback loop. Fine-tunes the metabolic fluctuations of UDP-GlcNAc and its impacts on hyaluronan synthesis during tissue remodeling (By similarity). Via control of the HPB, regulates the availability of precursors for N- and O-linked protein glycosylation and modulates peripheral clock oscillation (By similarity). {ECO:0000250|UniProtKB:P47856, ECO:0000250|UniProtKB:Q06210, ECO:0000269|PubMed:10898949}.
uniprot
proteins
mass_dalton
76827
uniprot
proteins
pathway_participation
PATHWAY: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-fructose 6-phosphate: step 1/1. {ECO:0000305|PubMed:10898949}.
uniprot
proteins
pubmed
10898949
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
681
uniprot
proteins