Mapre2
entrez
212307
canonical
uniprot
Q8R001
canonical
ensembl
ENSMUSG00000024277
resolver
ensp
ENSMUSP00000025127
resolver
ensp
ENSMUSP00000111496
resolver
ensp
ENSMUSP00000128040
resolver
enst
ENSMUST00000170802
resolver
genesymbol
Mapre2
resolver
uniprot
E9Q6X0
resolver
uniprot
Q3UF61
resolver
uniprot
Q8BLZ6
resolver
uniprot
Q8BYR6
resolver
uniprot
Q8C177
resolver
uniprot
Q8K109
resolver
uniprot_entry
E9Q6X0_MOUSE
resolver
uniprot_entry
MARE2_MOUSE
resolver
uniprot_sec
Q3UF61
resolver
uniprot_sec
Q8BLZ6
resolver
uniprot_sec
Q8BYR6
resolver
uniprot_sec
Q8C177
resolver
uniprot_sec
Q8K109
resolver
amino_acid_sequence
MPGPTQTLSPNGENNNDIIQDNGTIIPFRKHTVRGERSYSWGMAVNVYSTSITQETMSRHDIIAWVNDIVSLNYTKVEQLCSGAAYCQFMDMLFPGCISLKKVKFQAKLEHEYIHNFKLLQASFKRMNVDKVIPVEKLVKGRFQDNLDFIQWFKKFYDANYDGKEYDPVEARQGQDAIPPPDPGEQIFNLPKKSHHANSPTAGAAKSSPASKPGSTPSRPSSAKRASSSGSASRSDKDLETQVIQLNEQVHSLKLALEGVEKERDFYFGKLREIELLCQEHGQENDDLVQRLMEVLYASDEQEGQTEEPEAEEQAHDQQPQQQEEY
uniprot
proteins
function
FUNCTION: Adapter protein that is involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. Therefore, ensures mitotic progression and genome stability (By similarity). Acts as a central regulator of microtubule reorganization in apico-basal epithelial differentiation (PubMed:23813963). Plays a role during oocyte meiosis by regulating microtubule dynamics (PubMed:35398309). Participates in neurite growth by interacting with plexin B3/PLXNB3 and microtubule reorganization during apico-basal epithelial differentiation (By similarity). Plays also an essential role for cell migration and focal adhesion dynamics. Mechanistically, recruits HAX1 to microtubules in order to regulate focal adhesion dynamics (By similarity). {ECO:0000250|UniProtKB:Q15555, ECO:0000269|PubMed:23813963, ECO:0000269|PubMed:35398309}.
uniprot
proteins
mass_dalton
36946
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated in an ASB14-dependent manner; leading to proteasomal degradation. {ECO:0000269|PubMed:38319584}.; PTM: Phosphorylated at Ser-235 by CK2 leading to enhanced cell adhesion. Phosphorylated by CDK1 and AURKB during mitosis reduces the binding affinity of MAPRE2 for microtubules. {ECO:0000250|UniProtKB:Q15555}.
uniprot
proteins
protein_family
MAPRE family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21646404
uniprot
proteins
pubmed
23813963
uniprot
proteins
pubmed
35398309
uniprot
proteins
pubmed
38319584
uniprot
proteins
sequence_length
326
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:35398309}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:23813963}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:35398309}. Note=Associated with the microtubule network. Accumulates at the plus end of microtubules (PubMed:23813963). {ECO:0000269|PubMed:23813963, ECO:0000269|PubMed:35398309}.
uniprot
proteins