TP53INP1
entrez
94241
canonical
uniprot
Q96A56
canonical
ensembl
ENSG00000164938
resolver
ensp
ENSP00000344215
resolver
ensp
ENSP00000390063
resolver
genesymbol
TP53INP1
resolver
genesymbol_syn
P53DINP1
resolver
genesymbol_syn
SIP
resolver
hgnc
HGNC:18022
resolver
uniprot
B2RCE5
resolver
uniprot
Q969R9
resolver
uniprot_entry
T53I1_HUMAN
resolver
uniprot_sec
B2RCE5
resolver
uniprot_sec
Q969R9
resolver
amino_acid_sequence
MFQRLNKMFVGEVSSSSNQEPEFNEKEDDEWILVDFIDTCTGFSAEEEEEEEDISEESPTEHPSVFSCLPASLECLADTSDSCFLQFESCPMEESWFITPPPCFTAGGLTTIKVETSPMENLLIEHPSMSVYAVHNSCPGLSEATRGTDELHSPSSPRVEAQNEMGQHIHCYVAALAAHTTFLEQPKSFRPSQWIKEHSERQPLNRNSLRRQNLTRDCHPRQVKHNGWVVHQPCPRQYNY
uniprot
proteins
function
FUNCTION: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC. {ECO:0000269|PubMed:11511362, ECO:0000269|PubMed:22421968, ECO:0000269|PubMed:22470510}.
uniprot
proteins
mass_dalton
27366
uniprot
proteins
pubmed
11511362
uniprot
proteins
pubmed
12067065
uniprot
proteins
pubmed
12851404
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16377624
uniprot
proteins
pubmed
22421968
uniprot
proteins
pubmed
22470510
uniprot
proteins
sequence_length
240
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol. Nucleus. Nucleus, PML body. Cytoplasmic vesicle, autophagosome. Note=Shuttles between the nucleus and the cytoplasm, depending on cellular stress conditions, and re-localizes to autophagosomes on autophagy activation.
uniprot
proteins