FBXO2
entrez
26232
canonical
uniprot
Q9UK22
canonical
ensembl
ENSG00000116661
resolver
ensp
ENSP00000346240
resolver
enst
ENST00000354287
resolver
genesymbol
FBXO2
resolver
genesymbol_syn
FBX2
resolver
hgnc
HGNC:13581
resolver
uniprot
B2R7K7
resolver
uniprot
Q5TGY0
resolver
uniprot
Q6FGJ7
resolver
uniprot
Q8TB29
resolver
uniprot
Q9UKC6
resolver
uniprot_entry
FBX2_HUMAN
resolver
uniprot_sec
B2R7K7
resolver
uniprot_sec
Q5TGY0
resolver
uniprot_sec
Q6FGJ7
resolver
uniprot_sec
Q8TB29
resolver
uniprot_sec
Q9UKC6
resolver
amino_acid_sequence
MDGDGDPESVGQPEEASPEEQPEEASAEEERPEDQQEEEAAAAAAYLDELPEPLLLRVLAALPAAELVQACRLVCLRWKELVDGAPLWLLKCQQEGLVPEGGVEEERDHWQQFYFLSKRRRNLLRNPCGEEDLEGWCDVEHGGDGWRVEELPGDSGVEFTHDESVKKYFASSFEWCRKAQVIDLQAEGYWEELLDTTQPAIVVKDWYSGRSDAGCLYELTVKLLSEHENVLAEFSSGQVAVPQDSDGGGWMEISHTFTDYGPGVRFVRFEHGGQDSVYWKGWFGARVTNSSVWVEP
uniprot
proteins
function
FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
33328
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
10531035
uniprot
proteins
pubmed
10531037
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
21269460
uniprot
proteins
sequence_length
296
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Microsome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
uniprot
proteins