Adam7
entrez
11500
canonical
uniprot
O35227
canonical
ensembl
ENSMUSG00000022056
resolver
ensp
ENSMUSP00000022640
resolver
enst
ENSMUST00000022640
resolver
genesymbol
Adam7
resolver
uniprot
F8VQC6
resolver
uniprot_entry
ADAM7_MOUSE
resolver
uniprot_sec
F8VQC6
resolver
amino_acid_sequence
MLTTGIFWMTVLISHIQERGIVGVEGQELVHPKKLPLLHKRDLERIHDSDIPEEYEEELLYEIKLGKKTLILHLLKAREFLSSNYSETYYNVKREVFTKHPQILDHCFYQGSIIHEFDSAASISTCNGLRGFFRVNDQRYLIEPVKYSDDGEHLVYKYNVKAPYATNHSCVGLNFTKKSALIDVENIEEHNAEDHHKEKFIELFVVADEYVYRRNNKPQNKLRKRIWGMVNFVNMIYKTLNIHVTLAGFEIWSAGDKIEIVSNLESTLLHFSTWQETVLKKRKDFDHVILLSGKWLYTSMQGIAYPGGICQILRSCSVVKDLLPDVNIIGNRMAHQLGHSLGMQHDGFPCTCPLGKCVMGDGSIPAIKFSKCSQTQYQQFLQDQKPACILNNPFPEEFNDYPFCGNKKVDEGEECDCGPVQECTNPCCDAHKCVLKPGFTCVEGECCESCQMKKEGAVCRLAKNECDISEVCTGYSPECPKDEFQANGFPCRNGEGYCFMGLCPTRNEQCSELFIGGAEESHSLCYRMNKKGNRFGYCKNKGNTFVPCEEKDLKCGKIYCSGGRPSSRLGEDKAYNLKNVKQNVTIKCRTMFLHHNSRDMGLVNSGTKCGDGMVCSNGECIEMEKAYNSTICSSPCDENDVDDNEPECQCEEGSIITEWGEALNLTSVSIMVIVLVMVIIGVGLVILLIRYQKCIKMKQVQSSPREIRGVENKGYFPEEHQTRSEPILTDIHPLHTTAESLERVPSSFSSPHYITLKSVSKDSRGIADPKQTDNVNLNLDTQSGCERLG
uniprot
proteins
function
FUNCTION: Required for normal male fertility via maintenance of epithelial cell morphology in the caput epididymis and subsequently correct epididymis lumen structure required for sperm development (PubMed:26246218). Plays a role in sperm motility, flagella morphology and tyrosine phosphorylation during sperm capacitance (PubMed:26246218). Plays a role in normal expression levels of HSPA5, ITM2B and ADAM2 in sperm both prior to and post-capacitation (PubMed:26246218). This is a non catalytic metalloprotease-like protein (Probable). {ECO:0000269|PubMed:26246218, ECO:0000305|PubMed:9322939}.
uniprot
proteins
mass_dalton
89188
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20945367
uniprot
proteins
pubmed
26246218
uniprot
proteins
pubmed
9322939
uniprot
proteins
sequence_length
789
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305|PubMed:20945367}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 668..689; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins