Blnk
entrez
499356
canonical
uniprot
Q4KM52
canonical
ensembl
ENSRNOG00000013967
resolver
ensembl
ENSRNOG00055029752
resolver
ensembl
ENSRNOG00060027886
resolver
ensembl
ENSRNOG00065027493
resolver
ensp
ENSRNOP00000019014
resolver
ensp
ENSRNOP00055042527
resolver
ensp
ENSRNOP00060040470
resolver
ensp
ENSRNOP00065038957
resolver
enst
ENSRNOT00000019014
resolver
enst
ENSRNOT00055051583
resolver
enst
ENSRNOT00060048555
resolver
enst
ENSRNOT00065047471
resolver
genesymbol
Blnk
resolver
uniprot_entry
BLNK_RAT
resolver
amino_acid_sequence
MDKLNKITVPASQKLRQLQKMVHDIKNNEGGIMDKIKKLKVKGPPSVPRRDYALDNPADEEEQWSDDFDSDYENPDEHSDSEMYVMPAEETGDDSYEPPPAEQQTRVVHPALPFTRGEYVDNRSSQRHSPPFSKTLPSKPSWPSAKARLASTLPAPNSLQKPQVPPKPKDLLEDEADYVVPVEDNDENYIHPRESSPLPAEKAPTVNRSTKPNSSSKHVSPPGTVAGRNSGVWDSKSSLPAAPSPLPRAGKKTATPLKTTPVPSLQNASNVCEEKPVPAERHRGSSHRQDTVQSPVFPPTQKPVLQKPVPLPRFTEGGSPAADGPVPSFPFNSTFADQEAELHGKPWYAGACDRKSAEEALHRSNKDGSFLIRKSSGHDSKQPYTLVAFFNKRVYNIPVRFIEATKQYALGKKKNGEEYFGSVVEIIKNHQHNPLVLIDSQNNTKDSTRLKYAVKVS
uniprot
proteins
function
FUNCTION: Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
50634
uniprot
proteins
post_translational_modification
PTM: Following BCR activation, phosphorylated on tyrosine residues by SYK and LYN. When phosphorylated, serves as a scaffold to assemble downstream targets of antigen activation, including PLCG1, VAV1, GRB2 and NCK1. Phosphorylation of Tyr-84, Tyr-178 and Tyr-189 facilitates PLCG1 binding. Phosphorylation of Tyr-96 facilitates BTK binding. Phosphorylation of Tyr-72 facilitates VAV1 and NCK1 binding. Phosphorylation is required for both Ca(2+) and MAPK signaling pathways (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
457
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}. Note=BCR activation results in the translocation to membrane fraction. {ECO:0000250}.
uniprot
proteins