SERTAD2
entrez
9792
canonical
uniprot
Q14140
canonical
ensembl
ENSG00000179833
resolver
ensp
ENSP00000326933
resolver
ensp
ENSP00000529878
resolver
ensp
ENSP00000593314
resolver
ensp
ENSP00000628133
resolver
enst
ENST00000313349
resolver
enst
ENST00000859819
resolver
enst
ENST00000923255
resolver
enst
ENST00000958074
resolver
genesymbol
SERTAD2
resolver
genesymbol_syn
KIAA0127
resolver
genesymbol_syn
TRIPBR2
resolver
hgnc
HGNC:30784
resolver
uniprot
Q53TS2
resolver
uniprot_entry
SRTD2_HUMAN
resolver
uniprot_sec
Q53TS2
resolver
amino_acid_sequence
MLGKGGKRKFDEHEDGLEGKIVSPCDGPSKVSYTLQRQTIFNISLMKLYNHRPLTEPSLQKTVLINNMLRRIQEELKQEGSLRPMFTPSSQPTTEPSDSYREAPPAFSHLASPSSHPCDLGSTTPLEACLTPASLLEDDDDTFCTSQAMQPTAPTKLSPPALLPEKDSFSSALDEIEELCPTSTSTEAATAATDSVKGTSSEAGTQKLDGPQESRADDSKLMDSLPGNFEITTSTGFLTDLTLDDILFADIDTSMYDFDPCTSSSGTASKMAPVSADDLLKTLAPYSSQPVTPSQPFKMDLTELDHIMEVLVGS
uniprot
proteins
function
FUNCTION: Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism. {ECO:0000269|PubMed:11331592}.
uniprot
proteins
mass_dalton
33897
uniprot
proteins
mutagenesis
MUTAGEN 238; /note="L->A: Abolishes the interaction with XPO1 as well as the nuclear export and the subsequent proteasomal degradation."; /evidence="ECO:0000269|PubMed:18316374"; MUTAGEN 241; /note="L->A: Slight resistance to proteasomal degradation, no effect on the interaction with XPO1 neither on nuclear export."; /evidence="ECO:0000269|PubMed:18316374"; MUTAGEN 243; /note="L->A: Slight decrease of interaction with XPO1 and resistance to proteasomal degradation, no effect on nuclear export."; /evidence="ECO:0000269|PubMed:18316374
uniprot
proteins
post_translational_modification
PTM: Polyubiquitinated, which promotes proteasomal degradation. {ECO:0000269|PubMed:18316374}.
uniprot
proteins
pubmed
11331592
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
18316374
uniprot
proteins
pubmed
23291629
uniprot
proteins
pubmed
8590280
uniprot
proteins
sequence_length
314
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18316374}. Cytoplasm {ECO:0000269|PubMed:18316374}. Note=Exported out of the nucleus via its NES in a XPO1-dependent manner. Once in the cytoplasm, is degraded by the proteasome.
uniprot
proteins