MTERF1
entrez
7978
canonical
uniprot
Q99551
canonical
ensembl
ENSG00000127989
resolver
ensp
ENSP00000248643
resolver
ensp
ENSP00000384986
resolver
ensp
ENSP00000414116
resolver
ensp
ENSP00000537258
resolver
ensp
ENSP00000537259
resolver
ensp
ENSP00000609608
resolver
ensp
ENSP00000609609
resolver
enst
ENST00000351870
resolver
enst
ENST00000406735
resolver
enst
ENST00000419292
resolver
enst
ENST00000867199
resolver
enst
ENST00000867200
resolver
enst
ENST00000939549
resolver
enst
ENST00000939550
resolver
genesymbol
MTERF1
resolver
genesymbol_syn
MTERF
resolver
hgnc
HGNC:21463
resolver
uniprot
A4D1E3
resolver
uniprot
B4DPR9
resolver
uniprot
F6SGS2
resolver
uniprot
Q32NF8
resolver
uniprot
Q53H51
resolver
uniprot
Q9BVR7
resolver
uniprot_entry
B4DPR9_HUMAN
resolver
uniprot_entry
F6SGS2_HUMAN
resolver
uniprot_entry
MTEF1_HUMAN
resolver
uniprot_sec
A4D1E3
resolver
uniprot_sec
Q32NF8
resolver
uniprot_sec
Q53H51
resolver
uniprot_sec
Q9BVR7
resolver
amino_acid_sequence
MQSLSLGQTSISKGLNYLTIMAPGNLWHMRNNFLFGSRCWMTRFSAENIFKSVSFRLFGVKCHNTDSEPLKNEDLLKNLLTMGVDIDMARKRQPGVFHRMITNEQDLKMFLLSKGASKEVIASIISRYPRAITRTPENLSKRWDLWRKIVTSDLEIVNILERSPESFFRSNNNLNLENNIKFLYSVGLTRKCLCRLLTNAPRTFSNSLDLNKQMVEFLQAAGLSLGHNDPADFVRKIIFKNPFILIQSTKRVKANIEFLRSTFNLNSEELLVLICGPGAEILDLSNDYARRSYANIKEKLFSLGCTEEEVQKFVLSYPDVIFLAEKKFNDKIDCLMEENISISQIIENPRVLDSSISTLKSRIKELVNAGCNLSTLNITLLSWSKKRYEAKLKKLSRFA
uniprot
proteins
function
FUNCTION: Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand. {ECO:0000269|PubMed:20550934}.
uniprot
proteins
mass_dalton
45778
uniprot
proteins
mutagenesis
MUTAGEN 162; /note="R->A: Reduces affinity for cognate DNA; when associated with A-243 and A-288."; /evidence="ECO:0000269|PubMed:20550934"; MUTAGEN 169; /note="R->A: Strongly reduces affinity for DNA. Strongly reduces transcription termination."; /evidence="ECO:0000269|PubMed:20550934"; MUTAGEN 202; /note="R->A: Strongly reduces affinity for DNA. Strongly reduces transcription termination."; /evidence="ECO:0000269|PubMed:20550934"; MUTAGEN 243; /note="F->A: Reduces affinity for cognate DNA; when associated with A-162 and A-288."; /evidence="ECO:0000269|PubMed:20550934"; MUTAGEN 251; /note="R->A: Strongly reduces transcription termination."; /evidence="ECO:0000269|PubMed:20550934"; MUTAGEN 288; /note="Y->A: Reduces affinity for cognate DNA; when associated with A-162 and A-243."; /evidence="ECO:0000269|PubMed:20550934"; MUTAGEN 350; /note="R->A: Reduces transcription termination."; /evidence="ECO:0000269|PubMed:20550934"; MUTAGEN 387; /note="R->A: Strongly reduces affinity for cognate DNA. Strongly reduces transcription termination."; /evidence="ECO:0000269|PubMed:20550934
uniprot
proteins
post_translational_modification
PTM: Phosphoprotein with mostly four phosphate groups. While the DNA-binding activity is unaffected by the phosphorylation state, only the phosphorylated form of the protein is active for termination activity. Functioning seems to be regulated by phosphorylation. {ECO:0000269|PubMed:15087485}.
uniprot
proteins
protein_family
MTERF family
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15087485
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20543826
uniprot
proteins
pubmed
20550934
uniprot
proteins
pubmed
9118945
uniprot
proteins
sequence_length
399
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion.
uniprot
proteins