Clic4
entrez
29876
canonical
uniprot
Q9QYB1
canonical
ensembl
ENSMUSG00000037242
resolver
ensp
ENSMUSP00000041453
resolver
enst
ENSMUST00000037099
resolver
genesymbol
Clic4
resolver
uniprot
Q543N5
resolver
uniprot
Q8BMG5
resolver
uniprot_entry
CLIC4_MOUSE
resolver
uniprot_entry
Q543N5_MOUSE
resolver
uniprot_sec
Q8BMG5
resolver
amino_acid_sequence
MALSMPLNGLKEEDKEPLIELFVKAGSDGESIGNCPFSQRLFMILWLKGVVFSVTTVDLKRKPADLQNLAPGTHPPFITFNSEVKTDVNKIEEFLEEVLCPPKYLKLSPKHPESNTAGMDIFAKFSAYIKNSRPEANEALERGLLKTLQKLDEYLNSPLPDEIDENSMEDIKFSTRRFLDGDEMTLADCNLLPKLHIVKVVAKKYRNFDIPKGMTGIWRYLTNAYSRDEFTNTCPSDKEVEIAYSDVAKRLTK
uniprot
proteins
ec_number
1.8.-.-
uniprot
proteins
function
FUNCTION: In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor (By similarity). Can insert into membranes and form voltage-dependent multi-ion conductive channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions (By similarity). Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis). Promotes cell-surface expression of HRH3 (By similarity). {ECO:0000250|UniProtKB:Q9Y696, ECO:0000250|UniProtKB:Q9Z0W7}.
uniprot
proteins
mass_dalton
28729
uniprot
proteins
protein_family
Chloride channel CLIC family
uniprot
proteins
pubmed
10593946
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
17636002
uniprot
proteins
pubmed
19197003
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
253
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q9Y696}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:Q9Y696}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9Y696}. Nucleus {ECO:0000250|UniProtKB:Q9Y696}. Cell membrane {ECO:0000250|UniProtKB:Q9Y696}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9Y696}. Mitochondrion {ECO:0000269|PubMed:10593946, ECO:0000269|PubMed:17636002}. Cell junction {ECO:0000250|UniProtKB:Q9Y696}. Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles. Might not be present in the nucleus of cardiac cells. {ECO:0000250|UniProtKB:Q9Y696, ECO:0000250|UniProtKB:Q9Z0W7}.
uniprot
proteins
transmembrane_region
TRANSMEM 37..57; /note="Helical; Note=After insertion into the membrane"; /evidence="ECO:0000255
uniprot
proteins