SPAM1
entrez
6677
canonical
uniprot
P38567
canonical
ensembl
ENSG00000106304
resolver
ensp
ENSP00000345849
resolver
ensp
ENSP00000402123
resolver
ensp
ENSP00000417934
resolver
ensp
ENSP00000508393
resolver
genesymbol
SPAM1
resolver
genesymbol_syn
HEL-S-96n
resolver
genesymbol_syn
HYAL3
resolver
genesymbol_syn
PH20
resolver
hgnc
HGNC:11217
resolver
uniprot
Q5D1J4
resolver
uniprot
Q8TC30
resolver
uniprot_entry
HYALP_HUMAN
resolver
uniprot_entry
Q5D1J4_HUMAN
resolver
uniprot_sec
Q8TC30
resolver
amino_acid_sequence
MGVLKFKHIFFRSFVKSSGVSQIVFTFLLIPCCLTLNFRAPPVIPNVPFLWAWNAPSEFCLGKFDEPLDMSLFSFIGSPRINATGQGVTIFYVDRLGYYPYIDSITGVTVNGGIPQKISLQDHLDKAKKDITFYMPVDNLGMAVIDWEEWRPTWARNWKPKDVYKNRSIELVQQQNVQLSLTEATEKAKQEFEKAGKDFLVETIKLGKLLRPNHLWGYYLFPDCYNHHYKKPGYNGSCFNVEIKRNDDLSWLWNESTALYPSIYLNTQQSPVAATLYVRNRVREAIRVSKIPDAKSPLPVFAYTRIVFTDQVLKFLSQDELVYTFGETVALGASGIVIWGTLSIMRSMKSCLLLDNYMETILNPYIINVTLAAKMCSQVLCQEQGVCIRKNWNSSDYLHLNPDNFAIQLEKGGKFTVRGKPTLEDLEQFSEKFYCSCYSTLSCKEKADVKDTDAVDVCIADGVCIDAFLKPPMETEEPQIFYNASPSTLSATMFIVSILFLIISSVASL
uniprot
proteins
ec_number
3.2.1.35
uniprot
proteins
function
FUNCTION: Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid. {ECO:0000269|PubMed:8282124}.
uniprot
proteins
mass_dalton
57848
uniprot
proteins
mutagenesis
MUTAGEN 146; /note="D->N: Reduces activity by 80%."; /evidence="ECO:0000269|PubMed:9288901"; MUTAGEN 148; /note="E->Q: Loss of activity."; /evidence="ECO:0000269|PubMed:9288901"; MUTAGEN 211; /note="R->G: Reduces activity by over 90%."; /evidence="ECO:0000269|PubMed:9288901"; MUTAGEN 284; /note="E->Q: Loss of activity."; /evidence="ECO:0000269|PubMed:9288901"; MUTAGEN 287; /note="R->T: Loss of activity."; /evidence="ECO:0000269|PubMed:9288901
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:9288901}.
uniprot
proteins
protein_family
Glycosyl hydrolase 56 family
uniprot
proteins
pubmed
12690205
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
21248752
uniprot
proteins
pubmed
8234258
uniprot
proteins
pubmed
8282124
uniprot
proteins
pubmed
8575780
uniprot
proteins
pubmed
9288901
uniprot
proteins
sequence_length
509
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
uniprot
proteins