Jpt1
entrez
15374
canonical
uniprot
P97825
canonical
ensembl
ENSMUSG00000020737
resolver
ensp
ENSMUSP00000021083
resolver
enst
ENSMUST00000021083
resolver
genesymbol
Jpt1
resolver
genesymbol_syn
Hn1
resolver
uniprot_entry
JUPI1_MOUSE
resolver
amino_acid_sequence
MTTTTTFKGVDPNSRNSSRVLRPPGGGSNFSLGFDEPAEQPVRKNKMASNIFGTPEENPPSWAKSAGSKSSGGREDSESPGTQRSNSSEASSGDFLDLKGEGDMHENVDTDFQANLAQMEEKPVPAAPVPSPVAPAPVPSRRNPPGGKSSLVLG
uniprot
proteins
function
FUNCTION: Modulates negatively AKT-mediated GSK3B signaling. Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions (By similarity). Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteasomal degradation (By similarity). {ECO:0000250|UniProtKB:Q9UK76, ECO:0000269|PubMed:25450365}.
uniprot
proteins
mass_dalton
16081
uniprot
proteins
protein_family
JUPITER family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
23806337
uniprot
proteins
pubmed
25450365
uniprot
proteins
pubmed
9271675
uniprot
proteins
sequence_length
154
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UK76}. Cytoplasm {ECO:0000250|UniProtKB:Q9UK76}.
uniprot
proteins