PLK4
entrez
10733
canonical
uniprot
O00444
canonical
ensembl
ENSG00000142731
resolver
ensp
ENSP00000270861
resolver
ensp
ENSP00000423582
resolver
ensp
ENSP00000427554
resolver
ensp
ENSP00000523039
resolver
genesymbol
PLK4
resolver
genesymbol_syn
SAK
resolver
genesymbol_syn
STK18
resolver
hgnc
HGNC:11397
resolver
uniprot
B2RAL0
resolver
uniprot
B7Z837
resolver
uniprot
B7Z8G7
resolver
uniprot
Q8IYF0
resolver
uniprot
Q96Q95
resolver
uniprot
Q9UD84
resolver
uniprot
Q9UDE2
resolver
uniprot_entry
PLK4_HUMAN
resolver
uniprot_sec
B2RAL0
resolver
uniprot_sec
B7Z837
resolver
uniprot_sec
B7Z8G7
resolver
uniprot_sec
Q8IYF0
resolver
uniprot_sec
Q96Q95
resolver
uniprot_sec
Q9UD84
resolver
uniprot_sec
Q9UDE2
resolver
amino_acid_sequence
MATCIGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSIDSGHATISTAITASSSTSISGSLFDKRRLLIGQPLPNKMTVFPKNKSSTDFSSSGDGNSFYTQWGNQETSNSGRGRVIQDAEERPHSRYLRRAYSSDRSGTSNSQSQAKTYTMERCHSAEMLSVSKRSGGGENEERYSPTDNNANIFNFFKEKTSSSSGSFERPDNNQALSNHLCPGKTPFPFADPTPQTETVQQWFGNLQINAHLRKTTEYDSISPNRDFQGHPDLQKDTSKNAWTDTKVKKNSDASDNAHSVKQQNTMKYMTALHSKPEIIQQECVFGSDPLSEQSKTRGMEPPWGYQNRTLRSITSPLVAHRLKPIRQKTKKAVVSILDSEEVCVELVKEYASQEYVKEVLQISSDGNTITIYYPNGGRGFPLADRPPSPTDNISRYSFDNLPEKYWRKYQYASRFVQLVRSKSPKITYFTRYAKCILMENSPGADFEVWFYDGVKIHKTEDFIQVIEKTGKSYTLKSESEVNSLKEEIKMYMDHANEGHRICLALESIISEEERKTRSAPFFPIIIGRKPGSTSSPKALSPPPSVDSNYPTRERASFNRMVMHSAASPTQAPILNPSMVTNEGLGLTTTASGTDISSNSLKDCLPKSAQLLKSVFVKNVGWATQLTSGAVWVQFNDGSQLVVQAGVSSISYTSPNGQTTRYGENEKLPDYIKQKLQCLSSILLMFSNPTPNFH
uniprot
proteins
disease_involvement
DISEASE: Microcephaly and chorioretinopathy, autosomal recessive, 2 (MCCRP2) [MIM:616171]: A severe disorder characterized by microcephaly, delayed psychomotor development, growth retardation with dwarfism, and ocular abnormalities. {ECO:0000269|PubMed:25344692}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
ec_number
2.7.11.21
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CPAP, CCP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Phosphorylates 'Ser-151' of FBXW5 during the G1/S transition, leading to inhibit FBXW5 ability to ubiquitinate SASS6. Its central role in centriole replication suggests a possible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in deuterosome-mediated centriole amplification in multiciliated that can generate more than 100 centrioles. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2. Required for the recruitment of STIL to the centriole and for STIL-mediated centriole amplification (PubMed:22020124). Phosphorylates CEP131 at 'Ser-78' and PCM1 at 'Ser-372' which is essential for proper organization and integrity of centriolar satellites (PubMed:30804208). {ECO:0000269|PubMed:16244668, ECO:0000269|PubMed:16326102, ECO:0000269|PubMed:17681131, ECO:0000269|PubMed:18239451, ECO:0000269|PubMed:19164942, ECO:0000269|PubMed:21725316, ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27796307, ECO:0000269|PubMed:30804208}.
uniprot
proteins
mass_dalton
108972
uniprot
proteins
mutagenesis
MUTAGEN 13; /note="K->R: Does not affect interaction with UBP54."; /evidence="ECO:0000269|PubMed:36590171"; MUTAGEN 41; /note="K->M: Abolishes ability to phosphorylate CDC25C and CHEK2."; /evidence="ECO:0000269|PubMed:18239451, ECO:0000269|PubMed:19164942"; MUTAGEN 151; /note="K->R: Does not affect interaction with UBP54."; /evidence="ECO:0000269|PubMed:36590171"; MUTAGEN 154; /note="D->A: Catalytically inactive mutant that causes some centrosome amplification above background levels when overexpressed."; /evidence="ECO:0000269|PubMed:16244668"; MUTAGEN 162; /note="K->R: Abolishes interaction with UBP54."; /evidence="ECO:0000269|PubMed:36590171"; MUTAGEN 167; /note="K->R: Does not affect interaction with UBP54."; /evidence="ECO:0000269|PubMed:36590171"; MUTAGEN 170; /note="T->D: Activating mutant."; /evidence="ECO:0000269|PubMed:18239451, ECO:0000269|PubMed:19164942"; MUTAGEN 669; /note="N->R: Does not affect the interaction with TENT5C."; /evidence="ECO:0000269|PubMed:32433990"; MUTAGEN 670; /note="I->P: Decreases substantially the interaction with TENT5C. Does not affect localization to the centrosome. Loss of TENT5C recruitment to the centrosome."; /evidence="ECO:0000269|PubMed:32433990
uniprot
proteins
post_translational_modification
PTM: Acetylation by KAT2A and KAT2B impairs kinase activity by shifting the kinase to an inactive conformation. {ECO:0000269|PubMed:27796307}.; PTM: Ubiquitinated; leading to its degradation by the proteasome (By similarity). Deubiquitinated by USP54; leading to PLK4 stabilization (PubMed:36590171). {ECO:0000250|UniProtKB:Q64702, ECO:0000269|PubMed:36590171}.; PTM: Tyrosine-phosphorylated by TEC. {ECO:0000269|PubMed:11489907}.
uniprot
proteins
protein_family
CDC5/Polo subfamily
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
Ser/Thr protein kinase family
uniprot
proteins
pubmed
11489907
uniprot
proteins
pubmed
1311287
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15967108
uniprot
proteins
pubmed
16244668
uniprot
proteins
pubmed
16326102
uniprot
proteins
pubmed
17344846
uniprot
proteins
pubmed
17681131
uniprot
proteins
pubmed
18239451
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18691976
uniprot
proteins
pubmed
19164942
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
19454482
uniprot
proteins
pubmed
20852615
uniprot
proteins
pubmed
21059844
uniprot
proteins
pubmed
21725316
uniprot
proteins
pubmed
22020124
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25344692
uniprot
proteins
pubmed
27246242
uniprot
proteins
pubmed
27796307
uniprot
proteins
pubmed
30804208
uniprot
proteins
pubmed
32107292
uniprot
proteins
pubmed
32433990
uniprot
proteins
pubmed
36590171
uniprot
proteins
pubmed
8260651
uniprot
proteins
sequence_length
970
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:22020124, ECO:0000269|PubMed:27246242, ECO:0000269|PubMed:27796307}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q64702}. Cleavage furrow {ECO:0000250|UniProtKB:Q64702}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:30804208, ECO:0000269|PubMed:32433990}. Note=Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Associates with centrioles throughout the cell cycle. According to PubMed:16244668, it is not present at cleavage furrows.
uniprot
proteins