FZD8
entrez
8325
canonical
uniprot
Q9H461
canonical
ensembl
ENSG00000177283
resolver
ensp
ENSP00000363826
resolver
enst
ENST00000374694
resolver
genesymbol
FZD8
resolver
hgnc
HGNC:4046
resolver
uniprot_entry
FZD8_HUMAN
resolver
amino_acid_sequence
MEWGYLLEVTSLLAALALLQRSSGAAAASAKELACQEITVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNRTDLTTAAPSPPRRLPPPPPGEQPPSGSGHGRPPGARPPHRGGGRGGGGGDAAAPPARGGGGGGKARPPGGGAAPCEPGCQCRAPMVSVSSERHPLYNRVKTGQIANCALPCHNPFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDMERFKYPERPIIFLSACYLFVSVGYLVRLVAGHEKVACSGGAPGAGGAGGAGGAAAGAGAAGAGAGGPGGRGEYEELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQQDGPTKTHKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQHNRPRWEATHNCPCLRDLQPDQARRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWRSLCTRCCWASKGAAVGGGAGATAAGGGGGPGGGGGGGPGGGGGPGGGGGSLYSDVSTGLTWRSGTASSVSYPKQMPLSQV
uniprot
proteins
function
FUNCTION: Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1. {ECO:0000269|PubMed:11448771}.
uniprot
proteins
mass_dalton
73300
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by ZNRF3, leading to its degradation by the proteasome. {ECO:0000269|PubMed:22575959}.
uniprot
proteins
protein_family
G protein-coupled receptor Fz/Smo family
uniprot
proteins
pubmed
11295046
uniprot
proteins
pubmed
11448771
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
16882988
uniprot
proteins
pubmed
22575959
uniprot
proteins
pubmed
24496449
uniprot
proteins
sequence_length
694
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Golgi apparatus {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Colocalizes with GOPC at the Golgi apparatus. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 276..296; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 313..333; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 397..417; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 440..460; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 484..504; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 533..553; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 585..605; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins