GAL3ST2
entrez
64090
canonical
uniprot
Q9H3Q3
canonical
ensembl
ENSG00000154252
resolver
ensp
ENSP00000192314
resolver
enst
ENST00000192314
resolver
genesymbol
GAL3ST2
resolver
genesymbol_syn
GP3ST
resolver
hgnc
HGNC:24869
resolver
uniprot
Q17RK0
resolver
uniprot
Q57Z52
resolver
uniprot_entry
G3ST2_HUMAN
resolver
uniprot_sec
Q17RK0
resolver
uniprot_sec
Q57Z52
resolver
activity_regulation
ACTIVITY REGULATION: Strongly inhibited by Cu(2+) and Zn(2+) (PubMed:11029462). Activated by Mn(2+) up to a concentration of 10 mM, and the activity gradually decreased with further increase in Mn2(2+) concentration (PubMed:14701868). {ECO:0000269|PubMed:11029462, ECO:0000269|PubMed:14701868}.
uniprot
proteins
amino_acid_sequence
MMSMLGGLQRYFRVILLLLLALTLLLLAGFLHSDLELDTPLFGGQAEGPPVTNIMFLKTHKTASSTVLNILYRFAETHNLSVALPAGSRVHLGYPWLFLARYVEGVGSQQRFNIMCNHLRFNLPQVQKVMPNDTFYFSILRNPVFQLESSFIYYKTYAPAFRGAPSLDAFLASPRTFYNDSRHLRNVYAKNNMWFDFGFDPNAQCEEGYVRARIAEVERRFRLVLIAEHLDESLVLLRRRLRWALDDVVAFRLNSRSARSVARLSPETRERARSWCALDWRLYEHFNRTLWAQLRAELGPRRLRGEVERLRARRRELASLCLQDGGALKNHTQIRDPRLRPYQSGKADILGYNLRPGLDNQTLGVCQRLVMPELQYMARLYALQFPEKPLKNIPFLGA
uniprot
proteins
ec_number
2.8.2.-
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of a sulfate group from 3'-phosphoadenylyl sulfate (PAPS) to the C-3 hydroxyl group of terminal non-reducing beta-galactosyl residues (PubMed:11029462, PubMed:14701868, PubMed:15926885). Acts both on type 1 (Gal-beta-1,3-GlcNAc-R) and type 2 (Gal-beta-1,4-GlcNAc-R) chains with similar efficiency (PubMed:11029462, PubMed:14701868, PubMed:15926885). Displays species-dependent substrate specificity (PubMed:15926885). Participates in galactose sulfation and shows substrate preference for structures such as lactose, lacto-N-tetraose (Lc4), lacto-N-neotetraose (nLc4), the Gal-beta-1,4-GlcNAc-beta unit in mucin core-2, and the cancer antigen Globo H precursor Gal-beta-1,3-GlcNAc-beta-1,3-Gal-R (PubMed:11029462, PubMed:14701868, PubMed:15926885). {ECO:0000269|PubMed:11029462, ECO:0000269|PubMed:14701868, ECO:0000269|PubMed:15926885}.
uniprot
proteins
mass_dalton
46110
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; carbohydrate sulfation. {ECO:0000269|PubMed:11029462, ECO:0000269|PubMed:14701868, ECO:0000269|PubMed:15926885}.
uniprot
proteins
protein_family
Galactose-3-O-sulfotransferase family
uniprot
proteins
pubmed
11029462
uniprot
proteins
pubmed
14701868
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
15926885
uniprot
proteins
sequence_length
398
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000305|PubMed:11029462}; Single-pass type II membrane protein {ECO:0000305|PubMed:11029462}.
uniprot
proteins
transmembrane_region
TRANSMEM 11..31; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins