RAD54B
entrez
25788
canonical
uniprot
Q9Y620
canonical
ensembl
ENSG00000197275
resolver
ensp
ENSP00000336606
resolver
ensp
ENSP00000430153
resolver
genesymbol
RAD54B
resolver
hgnc
HGNC:17228
resolver
uniprot
F6WBS8
resolver
uniprot_entry
RA54B_HUMAN
resolver
uniprot_sec
F6WBS8
resolver
amino_acid_sequence
MRRSAAPSQLQGNSFKKPKFIPPGRSNPGLNEEITKLNPDIKLFEGVAINNTFLPSQNDLRICSLNLPSEESTREINNRDNCSGKYCFEAPTLATLDPPHTVHSAPKEVAVSKEQEEKSDSLVKYFSVVWCKPSKKKHKKWEGDAVLIVKGKSFILKNLEGKDIGRGIGYKFKELEKIEEGQTLMICGKEIEVMGVISPDDFSSGRCFQLGGGSTAISHSSQVARKCFSNPFKSVCKPSSKENRQNDFQNCKPRHDPYTPNSLVMPRPDKNHQWVFNKNCFPLVDVVIDPYLVYHLRPHQKEGIIFLYECVMGMRMNGRCGAILADEMGLGKTLQCISLIWTLQCQGPYGGKPVIKKTLIVTPGSLVNNWKKEFQKWLGSERIKIFTVDQDHKVEEFIKSIFYSVLIISYEMLLRSLDQIKNIKFDLLICDEGHRLKNSAIKTTTALISLSCEKRIILTGTPIQNDLQEFFALIDFVNPGILGSLSSYRKIYEEPIILSREPSASEEEKELGERRAAELTCLTGLFILRRTQEIINKYLPPKIENVVFCRPGALQIELYRKLLNSQVVRFCLQGLLENSPHLICIGALKKLCNHPCLLFNSIKEKECSSTCDKNEEKSLYKGLLSVFPADYNPLLFTEKESGKLQVLSKLLAVIHELRPTEKVVLVSNYTQTLNILQEVCKRHGYAYTRLDGQTPISQRQQIVDGFNSQHSSFFIFLLSSKAGGVGLNLIGGSHLILYDIDWNPATDIQAMSRVWRDGQKYPVHIYRLLTTGTIEEKIYQRQISKQGLCGAVVDLTKTSEHIQFSVEELKNLFTLHESSDCVTHDLLDCECTGEEVHTGDSLEKFIVSRDCQLGPHHQKSNSLKPLSMSQLKQWKHFSGDHLNLTDPFLERITENVSFIFQNITTQATGT
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: Multifunctional ATPase that could play with RAD54, a redundant role in homologous recombination (HR), a major pathway for repairing DNA double-strand breaks (DSBs), single-stranded DNA (ssDNA) gaps, and stalled or collapsed replication forks (PubMed:11884632, PubMed:16428451). Could act as a molecular motor during the homology search and guide RAD51 ssDNA along a donor dsDNA thereby changing the homology search from the diffusion-based mechanism to a motor-guided mechanism (PubMed:11782437, PubMed:11884632, PubMed:16428451). Once DNA strand exchange occured, could dissociate RAD51 from nucleoprotein filaments formed on dsDNA (By similarity). May also function as a molecular adapter, promoting MDM2-MDM4 heterodimerization to facilitate the ubiquitin-dependent degradation of p53, thereby modulating the cellular decision between cell cycle arrest and progression in response to DNA damage (PubMed:25384516). {ECO:0000250|UniProtKB:P32863, ECO:0000269|PubMed:11782437, ECO:0000269|PubMed:11884632, ECO:0000269|PubMed:16428451, ECO:0000269|PubMed:25384516}.
uniprot
proteins
mass_dalton
102967
uniprot
proteins
mutagenesis
MUTAGEN 332; /note="K->R: Loss of dsDNA-dependent ATPase activity."; /evidence="ECO:0000269|PubMed:11884632
uniprot
proteins
protein_family
SNF2/RAD54 helicase family
uniprot
proteins
pubmed
10362364
uniprot
proteins
pubmed
10851248
uniprot
proteins
pubmed
11782437
uniprot
proteins
pubmed
11884632
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
16428451
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25384516
uniprot
proteins
pubmed
25930971
uniprot
proteins
sequence_length
910
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus, nucleoplasm {ECO:0000269|PubMed:10851248, ECO:0000269|PubMed:16428451}. Note=Active at DNA double-strand breaks. {ECO:0000269|PubMed:16428451}.
uniprot
proteins