Dus2
entrez
66369
canonical
uniprot
Q9D7B1
canonical
ensembl
ENSMUSG00000031901
resolver
ensp
ENSMUSP00000034375
resolver
ensp
ENSMUSP00000271585
resolver
enst
ENSMUST00000034375
resolver
genesymbol
Dus2
resolver
genesymbol_syn
Dus2l
resolver
uniprot
Q14A90
resolver
uniprot
Q6PDX2
resolver
uniprot_entry
DUS2_MOUSE
resolver
uniprot_entry
Q14A90_MOUSE
resolver
uniprot_sec
Q6PDX2
resolver
amino_acid_sequence
MIVNSLSLCYHNKLILAPMVRVGTLPMRLLALDYGADIVYCEELIDLKMLQCKRVVNEVLSTVDFVAPDDRVVFRTCEREQSRVVFQMGTSDAERALAVARLVENDVAGIDVNMGCPKEYSTKGGMGAALLSDPDKIEKILSTLVKGTHRPVTCKIRILPSLEDTLNLVKRIERTGISAIAVHGRNRDERPQHPVSCEVIRAIAETLSIPVIANGGSHDHIQQHVDIEDFRQATAASSVMVARAAMWNPSIFLKDGLRPLEEVMQKYIRYAVQYDNHYTNTKYCLCQMLREQLESPQGRLLHAAQSSQEICEAFGLGAFYEETIRELDARRADLLAKTPEAVEEPAEDTSGIIKMAIRFDRRAYPPQITPKMCLLEWCRREKLPQPVYETVQRTIDRMFCSVVTVAEQKYQSTLWDKSKKLAEQTAAIVCLRSQGLPEGRLGEESPSLNKRKREAPDQDPGGPRVQEPALPGEICKKPFVTLDSSEENLLEGC
uniprot
proteins
ec_number
1.3.1.91
uniprot
proteins
function
FUNCTION: Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U20 in cytoplasmic tRNAs. Activity depends on the presence of guanosine at position 19 in the tRNA substrate. Negatively regulates the activation of EIF2AK2/PKR. {ECO:0000250|UniProtKB:Q9NX74}.
uniprot
proteins
mass_dalton
55325
uniprot
proteins
protein_family
Dus family
uniprot
proteins
protein_family
Dus2 subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
493
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9NX74}. Endoplasmic reticulum {ECO:0000250|UniProtKB:Q9NX74}. Note=Mainly at the endoplasmic reticulum. {ECO:0000250|UniProtKB:Q9NX74}.
uniprot
proteins