Lcp1
entrez
18826
canonical
uniprot
Q61233
canonical
ensembl
ENSMUSG00000021998
resolver
ensp
ENSMUSP00000116271
resolver
ensp
ENSMUSP00000117137
resolver
ensp
ENSMUSP00000121201
resolver
ensp
ENSMUSP00000183547
resolver
ensp
ENSMUSP00000183550
resolver
ensp
ENSMUSP00000183551
resolver
ensp
ENSMUSP00000183552
resolver
ensp
ENSMUSP00000183553
resolver
enst
ENSMUST00000124499
resolver
enst
ENSMUST00000131802
resolver
enst
ENSMUST00000145303
resolver
genesymbol
Lcp1
resolver
genesymbol_syn
Pls2
resolver
uniprot
Q3UE24
resolver
uniprot
Q8R1X3
resolver
uniprot
Q9CV77
resolver
uniprot_entry
PLSL_MOUSE
resolver
uniprot_sec
Q3UE24
resolver
uniprot_sec
Q8R1X3
resolver
uniprot_sec
Q9CV77
resolver
amino_acid_sequence
MARGSVSDEEMMELREAFAKVDTDGNGYISCNELNDLFKAACLPLPGYRVREITENLMATGDLDQDGKISFDEFIKVFHGLKSTEVAKTFRKAINKKEGICAIGGTSEQSSVGTQHSYSEEEKYAFVNWINKALENDPDCRHVIPMNPNTDDLFNAVGDGIVLCKMINLSVPDTIDERTINKKKLTPFTIQENLNLALNSASAIGCHVVNIGAEDLKEGKPYLVLGLLWQVIKIGLFADIELSRNEALIALLREGESLEDLMKLSPEELLLRWANYHLENAGCTKITNFSTDIKDSKAYYHLLEQVAPKGDEEGIPAVVIDMSGLREKDDIQRAECMLQQAERLGCRQFVTATDVVRGNPKLNLAFIANLFNKYPALHKPENQDIDWGALEGETREERTFRNWMNSLGVNPRVNHLYSDLSDALVIFQLYEKIKVPVDWNRVNKPPYPKLGGNMKKLENCNYAVDLGKNQAKFSLVGIAGQDLNEGNRTLTLALVWQLMRRYTLNILEDIGGGQKVNDDIIVNWVNTTLKEAQKSSSIASFKDPKISTSLPVLDLIDAIQPGSINYDLLKTENLDDEEKLNNAKYAISMARKIGARVYALPEDLVEVNPKMVMTVFACLMGKGMKRV
uniprot
proteins
function
FUNCTION: Actin-binding protein. Plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. Modulates the cell surface expression of IL2RA/CD25 and CD69. {ECO:0000250|UniProtKB:P13796}.
uniprot
proteins
mass_dalton
70149
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on a serine residue in response to costimulation through TCR/CD3 and CD2 or CD28. Serine phosphorylation promotes association with the actin cytoskeleton and targeting to peripheral cell projections (By similarity). {ECO:0000250}.
uniprot
proteins
pubmed
14756805
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7897227
uniprot
proteins
pubmed
8060349
uniprot
proteins
sequence_length
627
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:14756805}. Cell projection {ECO:0000250}. Cell junction {ECO:0000250}. Cell projection, ruffle membrane {ECO:0000269|PubMed:14756805}; Peripheral membrane protein {ECO:0000269|PubMed:14756805}; Cytoplasmic side {ECO:0000269|PubMed:14756805}. Note=Relocalizes to the immunological synapse between peripheral blood T-lymphocytes and antibody-presenting cells in response to costimulation through TCR/CD3 and CD2 or CD28. Relocalizes to actin-rich cell projections upon serine phosphorylation (By similarity). Associated with the actin cytoskeleton at membrane ruffles. {ECO:0000250|UniProtKB:P13796}.
uniprot
proteins