Q5M8Q2
uniprot
Q5M8Q2
canonical
amino_acid_sequence
MAKKMQRRRRQKRTRSQRGELPFSLVDRFLREEFHSSRLSSSALSFLTSVLEYLTSNILELAGEVAQTTGRKRIAPEDVRLVVQNNEQLRQLFKPGGTSVNEDDN
uniprot
proteins
function
FUNCTION: Atypical histone H2A which can replace conventional H2A in some nucleosomes and may play a role during spermatogenesis. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. {ECO:0000305|PubMed:17261847}.
uniprot
proteins
mass_dalton
12122
uniprot
proteins
protein_family
Histone H2A family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17261847
uniprot
proteins
pubmed
18703863
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
105
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17261847}. Chromosome {ECO:0000269|PubMed:17261847}. Note=Specifically localizes to the pericentric regions in condensing spermatids (PubMed:17261847). {ECO:0000269|PubMed:17261847}.
uniprot
proteins