Dohh
entrez
102115
canonical
uniprot
Q99LN9
canonical
ensembl
ENSMUSG00000078440
resolver
ensembl
ENSMUSG00000113262
resolver
ensp
ENSMUSP00000072534
resolver
genesymbol
Dohh
resolver
uniprot
Q8BNT3
resolver
uniprot
Q8BTD5
resolver
uniprot_entry
DOHH_MOUSE
resolver
uniprot_sec
Q8BNT3
resolver
uniprot_sec
Q8BTD5
resolver
amino_acid_sequence
MVTEQEIEAIGKTLVDPKQPLQARFRALFTLRGLGGPDAISWISRGFEDSSALLKHELAYCLGQMRDARAIPVLADVLQDTSQEPMVRHEAGEALGAIGNPEVLGLLKQYSTDPVVEVAETCQLAVGRLEWLQQHPGEATCAGPYLSVDPAPPAAEQDVGRLREALLDEARPLFERYRAMFALRNVGGKEAALALAEGLQCGSALFRHEVGYVLGQLQHEAAVPGLAATLARTTESPMVRHECAEALGAIARPACLAALREHIEDPEQVVRESCEVALDMYEYESSQDFQYADGLERLRPPP
uniprot
proteins
ec_number
1.14.99.29
uniprot
proteins
function
FUNCTION: Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. {ECO:0000255|HAMAP-Rule:MF_03101, ECO:0000269|PubMed:24832488}.
uniprot
proteins
mass_dalton
32905
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; eIF5A hypusination. {ECO:0000255|HAMAP-Rule:MF_03101, ECO:0000269|PubMed:24832488}.
uniprot
proteins
protein_family
Deoxyhypusine hydroxylase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24832488
uniprot
proteins
sequence_length
302
uniprot
proteins