FUT1
entrez
2523
canonical
uniprot
P19526
canonical
ensembl
ENSG00000174951
resolver
ensp
ENSP00000494643
resolver
ensp
ENSP00000597271
resolver
ensp
ENSP00000597272
resolver
enst
ENST00000645652
resolver
enst
ENST00000927212
resolver
enst
ENST00000927213
resolver
genesymbol
FUT1
resolver
genesymbol_syn
H
resolver
genesymbol_syn
HSC
resolver
hgnc
HGNC:4012
resolver
uniprot
O14505
resolver
uniprot
O14506
resolver
uniprot
O14507
resolver
uniprot
Q6IZA2
resolver
uniprot_entry
FUT1_HUMAN
resolver
uniprot_entry
Q6IZA2_HUMAN
resolver
uniprot_sec
O14505
resolver
uniprot_sec
O14506
resolver
uniprot_sec
O14507
resolver
amino_acid_sequence
MWLRSHRQLCLAFLLVCVLSVIFFLHIHQDSFPHGLGLSILCPDRRLVTPPVAIFCLPGTAMGPNASSSCPQHPASLSGTWTVYPNGRFGNQMGQYATLLALAQLNGRRAFILPAMHAALAPVFRITLPVLAPEVDSRTPWRELQLHDWMSEEYADLRDPFLKLSGFPCSWTFFHHLREQIRREFTLHDHLREEAQSVLGQLRLGRTGDRPRTFVGVHVRRGDYLQVMPQRWKGVVGDSAYLRQAMDWFRARHEAPVFVVTSNGMEWCKENIDTSQGDVTFAGDGQEATPWKDFALLTQCNHTIMTIGTFGFWAAYLAGGDTVYLANFTLPDSEFLKIFKPEAAFLPEWVGINADLSPLWTLAKP
uniprot
proteins
ec_number
2.4.1.344
uniprot
proteins
ec_number
2.4.1.69
uniprot
proteins
function
FUNCTION: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose residue of glycoconjugates through an alpha(1,2) linkage leading to H antigen synthesis that is an intermediate substrate in the synthesis of ABO blood group antigens (PubMed:2118655). H antigen is essential for maturation of the glomerular layer of the main olfactory bulb, in cell migration and early cell-cell contacts during tumor associated angiogenesis (PubMed:18205178). Preferentially fucosylates soluble lactose and to a lesser extent fucosylates glycolipids gangliosides GA1 and GM1a (By similarity). {ECO:0000250|UniProtKB:O09160, ECO:0000269|PubMed:18205178, ECO:0000269|PubMed:2118655}.
uniprot
proteins
mass_dalton
41251
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000269|PubMed:2118655}.
uniprot
proteins
protein_family
Glycosyltransferase 11 family
uniprot
proteins
pubmed
15057824
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18205178
uniprot
proteins
pubmed
2118655
uniprot
proteins
pubmed
7912436
uniprot
proteins
pubmed
9122901
uniprot
proteins
pubmed
9226185
uniprot
proteins
pubmed
9299444
uniprot
proteins
sequence_length
365
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:O09160}; Single-pass type II membrane protein {ECO:0000250|UniProtKB:O09160}. Note=Membrane-bound form in trans cisternae of Golgi. {ECO:0000250|UniProtKB:O09160}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..25; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins