Gucy2e
entrez
79222
canonical
uniprot
P51840
canonical
ensembl
ENSRNOG00000007931
resolver
ensembl
ENSRNOG00055032667
resolver
ensembl
ENSRNOG00060021742
resolver
ensembl
ENSRNOG00065026105
resolver
ensp
ENSRNOP00000010790
resolver
ensp
ENSRNOP00055046557
resolver
ensp
ENSRNOP00060031055
resolver
ensp
ENSRNOP00065036887
resolver
enst
ENSRNOT00000010790
resolver
enst
ENSRNOT00055056451
resolver
enst
ENSRNOT00060037663
resolver
enst
ENSRNOT00065045002
resolver
genesymbol
Gucy2e
resolver
genesymbol_syn
Guc2e
resolver
genesymbol_syn
Gucy2d
resolver
uniprot_entry
GUC2E_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by GUCA1A when free calcium ions concentration is low, and inhibited by GUCA1A when free calcium ions concentration is high (By similarity). Negatively regulated by RD3; inhibits the basal and GUCA1A-stimulated guanylate cyclase activity (By similarity). {ECO:0000250|UniProtKB:P52785, ECO:0000250|UniProtKB:Q02846}.
uniprot
proteins
amino_acid_sequence
MSAWLLPAGGFPGAGFCIPAWQSRSSLSRVLRWPGPGLPGLLLLLLLPSPSAFSAVFKVGVLGPWACDPIFARARPDLAARLATDRLNRDLALDGGPWFEVTLLPEPCLTPGSLGAVSSALTRVSGLVGPVNPAACRPAELLAQEAGVALVPWGCPGTRAAGTTAPAVTPAADALYVLLKAFRWARVALITAPQDLWVEAGRALSTALRARGLPVALVTSMVPSDLSGAREALRRIRDGPRVRVVIMVMHSVLLGGEEQRYLLEAAEELGLTDGSLVFLPFDTLHYALSPGPEALAAFVNSSKLRRAHDAVLTLTRRCPPGGSVQDSLRRAQEHQELPLDLDLKQVSPLFGTIYDAVFLLAGGVTRARAAVGGGWVSGASVARQMREAQVFGFCGILGRTEEPSFVLLDTDAAGERLFTTHLLDPVLGSLRSAGTPVHFPRGAPAPGPDPSCWFDPDVICNGGVEPGLVFVGFLLVIVVGLTGAFLAHYLRHRLLHMQMVSGPNKIILTLEDVTFLHPQGGSSRKVAQGSRSSLATRSTSDIRSVPSQPQESTNIGLYEGDWVWLKKFPGEHHMAIRPATKMAFSKLRELRHENVALYLGLFLAGTADSPATPGEGILAVVSEHCARGSLHDLLAQRDIKLDWMFKSSLLLDLIKGMRYLHHRGVAHGRLKSRNCVVDGRFVLKVTDHGHGRLLEAQRVLPEPPSAEDQLWTAPELLRDPALERRGTLAGDVFSLGIIMQEVVCRSTPYAMLELTPEEVIQRVRSPPPLCRPLVSMDQAPMECIQLMAQCWAEHPELRPSMDLTFDLFKGINKGRKTNIIDSMLRMLEQYSSNLEDLIRERTEELEQEKQKTDRLLTQMLPPSVAEALKMGTSVEPEYFEEVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGSFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNMSTVRILRALDQGFQMECRGRTELKGKGVEDTYWLVGRVGFNKPIPKPPDLQPGASNHGISLQEIPPERRKKLEKARPGQFTGK
uniprot
proteins
ec_number
4.6.1.2
uniprot
proteins
function
FUNCTION: Catalyzes the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment. May also participate in the trafficking of membrane-associated proteins to the photoreceptor outer segment membrane. {ECO:0000250|UniProtKB:P52785}.
uniprot
proteins
mass_dalton
120801
uniprot
proteins
post_translational_modification
PTM: There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds.
uniprot
proteins
protein_family
Adenylyl cyclase class-4/guanylyl cyclase family
uniprot
proteins
pubmed
7831337
uniprot
proteins
pubmed
9153227
uniprot
proteins
sequence_length
1108
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:7831337}; Single-pass type I membrane protein. Photoreceptor outer segment membrane {ECO:0000269|PubMed:7831337, ECO:0000269|PubMed:9153227}; Single-pass type I membrane protein. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q02846}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 466..490; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins