GRIK2
entrez
2898
canonical
uniprot
Q13002
canonical
ensembl
ENSG00000164418
resolver
ensp
ENSP00000358130
resolver
ensp
ENSP00000358134
resolver
ensp
ENSP00000405596
resolver
ensp
ENSP00000506840
resolver
ensp
ENSP00000508069
resolver
genesymbol
GRIK2
resolver
genesymbol_syn
GLUR6
resolver
hgnc
HGNC:4580
resolver
uniprot
A0A8D9PH75
resolver
uniprot
A6NMY9
resolver
uniprot
A8K0H7
resolver
uniprot
B5MCV0
resolver
uniprot
D7RWZ3
resolver
uniprot
D7RWZ4
resolver
uniprot
D7RWZ5
resolver
uniprot
D7RWZ6
resolver
uniprot
D7RWZ7
resolver
uniprot
Q8IY40
resolver
uniprot
Q8WWS1
resolver
uniprot
Q96KS6
resolver
uniprot
Q96KS7
resolver
uniprot
Q96KS8
resolver
uniprot_entry
A0A8D9PH75_HUMAN
resolver
uniprot_entry
A8K0H7_HUMAN
resolver
uniprot_entry
GRIK2_HUMAN
resolver
uniprot_entry
Q8IY40_HUMAN
resolver
uniprot_sec
A6NMY9
resolver
uniprot_sec
B5MCV0
resolver
uniprot_sec
D7RWZ3
resolver
uniprot_sec
D7RWZ4
resolver
uniprot_sec
D7RWZ5
resolver
uniprot_sec
D7RWZ6
resolver
uniprot_sec
D7RWZ7
resolver
uniprot_sec
Q8WWS1
resolver
uniprot_sec
Q96KS6
resolver
uniprot_sec
Q96KS7
resolver
uniprot_sec
Q96KS8
resolver
activity_regulation
ACTIVITY REGULATION: Ionotropic glutamate receptor activity is promoted by positive allosteric modulators that inhibit receptor desensitization (By similarity). Ionotropic glutamate receptor activity is inhibited by ion channel blockers (By similarity).Cold receptor activity is activated by temperatures between 10-19 degrees Celsius. {ECO:0000250|UniProtKB:P42260, ECO:0000269|PubMed:31474366}.
uniprot
proteins
amino_acid_sequence
MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGAQDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVGEFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA
uniprot
proteins
disease_involvement
DISEASE: Intellectual developmental disorder, autosomal recessive 6 (MRT6) [MIM:611092]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT6 patients display mild to severe intellectual disability and psychomotor development delay in early childhood. Patients do not have neurologic problems, congenital malformations, or facial dysmorphism. Body height, weight, and head circumference are normal. {ECO:0000269|PubMed:17847003}. Note=The disease is caused by variants affecting the gene represented in this entry.; DISEASE: Neurodevelopmental disorder with impaired language and ataxia and with or without seizures (NEDLAS) [MIM:619580]: An autosomal dominant disorder characterized by axial hypotonia and global developmental delay. Affected individuals show impaired intellectual development, delayed walking, poor speech, and behavioral abnormalities. Some patients have a more severe phenotype with early-onset seizures resembling epileptic encephalopathy, inability to walk or speak, and hypomyelination on brain imaging. {ECO:0000269|PubMed:28180184, ECO:0000269|PubMed:34375587}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Ionotropic glutamate receptor that functions as a cation-permeable ligand-gated ion channel, gated by L-glutamate and the glutamatergic agonist kainic acid (PubMed:7536611, PubMed:8730589, PubMed:14511640). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system (By similarity). Binding of the excitatory neurotransmitter L-glutamate induces a conformational change leading to the opening of the cation channel, converting the chemical signal to an electrical impulse (By similarity). The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:14511640, PubMed:28180184, PubMed:34375587, PubMed:7536611, PubMed:8730589). Modulates cell surface expression of NETO2 (By similarity). In association with GRIK3, involved in presynaptic facilitation of glutamate release at hippocampal mossy fiber synapses (By similarity). {ECO:0000250|UniProtKB:P39087, ECO:0000269|PubMed:14511640, ECO:0000269|PubMed:28180184, ECO:0000269|PubMed:34375587, ECO:0000269|PubMed:7536611, ECO:0000269|PubMed:8730589}.; FUNCTION: Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures (PubMed:31474366). Functions in dorsal root ganglion neurons (By similarity). {ECO:0000250|UniProtKB:P39087, ECO:0000269|PubMed:31474366}.
uniprot
proteins
mass_dalton
102583
uniprot
proteins
post_translational_modification
PTM: Sumoylation mediates kainate receptor-mediated endocytosis and regulates synaptic transmission. Sumoylation is enhanced by PIAS3 and desumoylated by SENP1 (By similarity). {ECO:0000250|UniProtKB:P42260}.; PTM: Ubiquitinated. Ubiquitination regulates the GRIK2 levels at the synapse by leading kainate receptor degradation through proteasome (By similarity). {ECO:0000250|UniProtKB:P42260}.; PTM: Phosphorylated by PKC at Ser-868 upon agonist activation, this directly enhance sumoylation. {ECO:0000269|PubMed:22808340}.
uniprot
proteins
protein_family
GRIK2 subfamily
uniprot
proteins
protein_family
Glutamate-gated ion channel (TC 1.A.10.1) family
uniprot
proteins
pubmed
11675011
uniprot
proteins
pubmed
11744724
uniprot
proteins
pubmed
14511640
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
17847003
uniprot
proteins
pubmed
20230879
uniprot
proteins
pubmed
21893069
uniprot
proteins
pubmed
22808340
uniprot
proteins
pubmed
28180184
uniprot
proteins
pubmed
31474366
uniprot
proteins
pubmed
34375587
uniprot
proteins
pubmed
7523595
uniprot
proteins
pubmed
7536611
uniprot
proteins
pubmed
7696618
uniprot
proteins
pubmed
8034316
uniprot
proteins
pubmed
8730589
uniprot
proteins
sequence_length
908
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14511640, ECO:0000269|PubMed:34375587}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P42260}. Postsynaptic cell membrane {ECO:0000250|UniProtKB:P42260}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P42260}.
uniprot
proteins
transmembrane_region
TRANSMEM 552..585; /note="Helical; Name=M1"; /evidence="ECO:0000250|UniProtKB:P42260"; TRANSMEM 630..660; /note="Helical; Name=M3"; /evidence="ECO:0000250|UniProtKB:P42260"; TRANSMEM 816..840; /note="Helical; Name=M4"; /evidence="ECO:0000250|UniProtKB:P42260
uniprot
proteins