Slc22a4
entrez
64037
canonical
uniprot
Q9R141
canonical
ensembl
ENSRNOG00000046195
resolver
ensembl
ENSRNOG00055025539
resolver
ensembl
ENSRNOG00060024589
resolver
ensembl
ENSRNOG00065005711
resolver
ensp
ENSRNOP00000055693
resolver
ensp
ENSRNOP00055036062
resolver
ensp
ENSRNOP00060035270
resolver
ensp
ENSRNOP00065006015
resolver
enst
ENSRNOT00000058907
resolver
enst
ENSRNOT00055044085
resolver
enst
ENSRNOT00060042581
resolver
enst
ENSRNOT00065008531
resolver
genesymbol
Slc22a4
resolver
genesymbol_syn
Octn1
resolver
uniprot_entry
S22A4_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Allosterically activated by intracellular ATP. {ECO:0000250|UniProtKB:Q9H015}.
uniprot
proteins
amino_acid_sequence
MRDYDEVIAFLGDWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHRCLVPHTVNLSSAWRNHSIPLETKDGRQVPQSCRRYRLATIANFSALGLEPGLDVDLEQLEQESCLDGWEYSKDVFLSTIVTEWNLVCEDDWKTPLTTSLFFVGVLCGSFVSGQLSDRFGRKKVLFATMAVQTGFSFVQIFSTNWEMFTVLFAIVGMGQISNYVVAFILGTEILSKSVRILFSTLGVCTFFAIGYMVLPLFAYFIRDWRMLLLALTLPGLFCVPLWWFIPESPRWLISQRRFEEAEQIIQKAAKMNGIMAPAVIFDPLELQELNSLKQQKVFILDLFKTRNIATITVMSVMLWMLTSVGYFALSLNVPNLHGDVYLNCFLSGLIEVPAYFTAWLLLRTLPRRYIIAGVLFWGGGVLLLVQVVPEDYNFVSIGLVMLGKFGVTSAFSMLYVFTAELYPTLVRNMAVGITSMASRVGSIIAPYFVYLGAYNRLLPYILMGSLTVLIGIITLFFPESFGVTLPENLEQMQKVRGFRCGKKSTVSMDREENPKVLITAF
uniprot
proteins
function
FUNCTION: Transporter that mediates the transport of endogenous and microbial zwitterions and organic cations (PubMed:18670092). Functions as a Na(+)-dependent and pH-dependent high affinity microbial symporter of potent food-derived antioxidant ergothioeine (PubMed:18670092). Transports one sodium ion with one ergothioeine molecule (PubMed:18670092). Involved in the absorption of ergothioneine from the luminal/apical side of the small intestine and renal tubular cells, and into non-parenchymal liver cells, thereby contributing to maintain steady-state ergothioneine level in the body (By similarity). Also mediates the bidirectional transport of acetycholine, although the exact transport mechanism has not been fully identified yet (By similarity). Most likely exports anti-inflammatory acetylcholine in non-neuronal tissues, thereby contributing to the non-neuronal cholinergic system (By similarity). Displays a general physiological role linked to better survival by controlling inflammation and oxidative stress, which may be related to ergothioneine and acetycholine transports (By similarity). May contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (PubMed:17616214). {ECO:0000250|UniProtKB:Q9H015, ECO:0000269|PubMed:17616214, ECO:0000269|PubMed:18670092}.
uniprot
proteins
mass_dalton
62362
uniprot
proteins
protein_family
Major facilitator (TC 2.A.1) superfamily
uniprot
proteins
protein_family
Organic cation transporter (TC 2.A.1.19) family
uniprot
proteins
pubmed
10825452
uniprot
proteins
pubmed
17616214
uniprot
proteins
pubmed
18670092
uniprot
proteins
sequence_length
553
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000250|UniProtKB:Q9H015}; Multi-pass membrane protein {ECO:0000305}. Basal cell membrane {ECO:0000250|UniProtKB:Q9H015}; Multi-pass membrane protein {ECO:0000305}. Mitochondrion membrane {ECO:0000250|UniProtKB:Q9H015}; Multi-pass membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 21..41; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 143..163; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 172..192; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 198..218; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 233..253; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 258..278; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 340..360; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 374..394; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 401..421; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 429..449; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 463..483; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 489..509; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins