Hnf4a
entrez
25735
canonical
uniprot
P22449
canonical
ensembl
ENSRNOG00000008895
resolver
ensp
ENSRNOP00000071432
resolver
ensp
ENSRNOP00000073501
resolver
enst
ENSRNOT00000078703
resolver
enst
ENSRNOT00000089893
resolver
genesymbol
Hnf4a
resolver
genesymbol_syn
Hnf-4
resolver
genesymbol_syn
Hnf4
resolver
genesymbol_syn
Hnf4alpha
resolver
genesymbol_syn
Nr2a1
resolver
genesymbol_syn
Tcf14
resolver
uniprot
A0A0G2K0G1
resolver
uniprot
A0A0G2K5P1
resolver
uniprot
A2ICG7
resolver
uniprot
A2ICG9
resolver
uniprot
B9VVT2
resolver
uniprot
B9VVT3
resolver
uniprot_entry
A0A0G2K0G1_RAT
resolver
uniprot_entry
A0A0G2K5P1_RAT
resolver
uniprot_entry
A2ICG7_RAT
resolver
uniprot_entry
B9VVT2_RAT
resolver
uniprot_entry
B9VVT3_RAT
resolver
uniprot_entry
HNF4A_RAT
resolver
uniprot_sec
A2ICG9
resolver
amino_acid_sequence
MRLSKTLADMDMADYSAALDPAYTTLEFENVQVLTMGNDTSPSEGANLNSSNSLGVSALCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHMYSCRFSRQCVVDKDKRNQCRYCRLKKCFRAGMKKEAVQNERDRISTRRSSYEDSSLPSINALLQAEVLSQQITSPISGINGDIRAKKIANITDVCESMKEQLLVLVEWAKYIPAFCELLLDDQVALLRAHAGEHLLLGATKRSMVFKDVLLLGNDYIVPRHCPELAEMSRVSIRILDELVLPFQELQIDDNEYACLKAIIFFDPDAKGLSDPGKIKRLRSQVQVSLEDYINDRQYDSRGRFGELLLLLPTLQSITWQMIEQIQFIKLFGMAKIDNLLQEMLLGGSASDAPHAHHPLHPHLMQEHMGTNVIVANTMPSHLSNGQMCEWPRPRGQAATPETPQPSPPSGSGSESYKLLPGAITTIVKPPSAIPQPTITKQEAI
uniprot
proteins
function
FUNCTION: Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (By similarity). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (By similarity). {ECO:0000250|UniProtKB:P41235, ECO:0000250|UniProtKB:P49698}.
uniprot
proteins
mass_dalton
52712
uniprot
proteins
mutagenesis
MUTAGEN 142..143; /note="SS->AG: Loss of phosphorylation, no effect on DNA-binding."; /evidence="ECO:0000269|PubMed:9234678"; MUTAGEN 142..143; /note="SS->LE: Loss of phosphorylation, no effect on DNA-binding."; /evidence="ECO:0000269|PubMed:9234678
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-313 by AMPK reduces the ability to form homodimers and bind DNA (By similarity). Phosphorylated in the recognition sequence R-R-S-S near the DNA-binding domain; phosphorylation results in decrease in DNA-binding activity. Phosphorylation of HNF4 depends on the diet and is decreased by a carbohydrate-rich diet and is increased by fasting. {ECO:0000250, ECO:0000269|PubMed:9234678}.; PTM: The N-terminus is blocked.; PTM: Acetylation at Lys-458 lowers transcriptional activation by about two-fold. {ECO:0000250}.
uniprot
proteins
protein_family
NR2 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
12193589
uniprot
proteins
pubmed
1610903
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
2279702
uniprot
proteins
pubmed
9234678
uniprot
proteins
sequence_length
474
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins