Slc6a3
entrez
13162
canonical
uniprot
Q61327
canonical
ensembl
ENSMUSG00000021609
resolver
ensp
ENSMUSP00000022100
resolver
enst
ENSMUST00000022100
resolver
genesymbol
Slc6a3
resolver
genesymbol_syn
Dat
resolver
genesymbol_syn
Dat1
resolver
uniprot
Q60719
resolver
uniprot
Q9R1I2
resolver
uniprot_entry
SC6A3_MOUSE
resolver
uniprot_sec
Q60719
resolver
uniprot_sec
Q9R1I2
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by amphetamine, bupropion, cocaine and ritalin (PubMed:10375632). Inhibited by zinc ions (By similarity). {ECO:0000250|UniProtKB:Q01959, ECO:0000269|PubMed:10375632}.
uniprot
proteins
amino_acid_sequence
MSKSKCSVGPMSSVVAPAKEPNAVGPREVELILVKEQNGVQLTNSTLINPPQTPVEVQERETWSKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPVLKGVGFTVILISFYVGFFYNVIIAWALHYFFSSFTMDLPWIHCNNTWNSPNCSDAHSSNSSDGLGLNDTFGTTPAAEYFERGVLHLHQSRGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAMDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIITTSINSLTSFSSGFVVFSFLGYMAQKHNVPIRDVATDGPGLIFIIYPEAIATLPLSSAWAAVFFLMLLTLGIDSAMGGMESVITGLVDEFQLLHRHRELFTLGIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVQQFSDDIKQMTGQRPNLYWRLCWKLVSPCFLLYVVVVSIVTFRPPHYGAYIFPDWANALGWIIATSSMAMVPIYATYKFCSLPGSFREKLAYAITPEKDRQLVDRGEVRQFTLRHWLLV
uniprot
proteins
function
FUNCTION: Mediates sodium- and chloride-dependent transport of dopamine (PubMed:10375632, PubMed:12606774). Also mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline) (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (PubMed:30936473). {ECO:0000250|UniProtKB:P23977, ECO:0000269|PubMed:10375632, ECO:0000269|PubMed:12606774, ECO:0000269|PubMed:30936473}.
uniprot
proteins
mass_dalton
68805
uniprot
proteins
mutagenesis
MUTAGEN 105; /note="F->A,I,L,N,Q,S,T: Very low dopamine transporter activity."; /evidence="ECO:0000269|PubMed:12606774"; MUTAGEN 105; /note="F->C: Reduced sensitivity to cocaine."; /evidence="ECO:0000269|PubMed:12606774"; MUTAGEN 105; /note="F->M: Functional dopamine transporter with 4-fold decrease in cocaine sensitivity."; /evidence="ECO:0000269|PubMed:12606774"; MUTAGEN 105; /note="F->W,Y: Retention of dopamine transporter activity and high sensitivity to cocaine."; /evidence="ECO:0000269|PubMed:12606774
uniprot
proteins
protein_family
SLC6A3 subfamily
uniprot
proteins
protein_family
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
uniprot
proteins
pubmed
10375632
uniprot
proteins
pubmed
12177201
uniprot
proteins
pubmed
12606774
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17296554
uniprot
proteins
pubmed
19357284
uniprot
proteins
pubmed
30936473
uniprot
proteins
pubmed
7637582
uniprot
proteins
sequence_length
619
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12606774}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q01959}. Cell projection, neuron projection {ECO:0000250|UniProtKB:P23977}. Cell projection, axon {ECO:0000269|PubMed:17296554}. Note=Localizes to neurite tips in neuronal cells (By similarity). Colocalizes with SEPTIN4 at axon terminals, especially at the varicosities (PubMed:17296554). {ECO:0000250|UniProtKB:P23977, ECO:0000269|PubMed:17296554}.
uniprot
proteins
transmembrane_region
TRANSMEM 57..95; /note="Discontinuously helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q01959"; TRANSMEM 96..127; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q01959"; TRANSMEM 128..171; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q01959"; TRANSMEM 236..255; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q01959"; TRANSMEM 256..286; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q01959"; TRANSMEM 306..334; /note="Discontinuously helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q01959"; TRANSMEM 335..375; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q01959"; TRANSMEM 400..441; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q01959"; TRANSMEM 442..465; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q01959"; TRANSMEM 466..498; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q01959"; TRANSMEM 516..541; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q01959"; TRANSMEM 553..582; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:Q01959
uniprot
proteins