Mphosph8
entrez
290270
canonical
uniprot
G3V8T1
canonical
ensembl
ENSRNOG00000061152
resolver
ensembl
ENSRNOG00055012239
resolver
ensembl
ENSRNOG00060017589
resolver
ensembl
ENSRNOG00065031728
resolver
ensp
ENSRNOP00000028145
resolver
ensp
ENSRNOP00055016810
resolver
ensp
ENSRNOP00060024378
resolver
ensp
ENSRNOP00065044970
resolver
enst
ENSRNOT00000028145
resolver
enst
ENSRNOT00055020832
resolver
enst
ENSRNOT00060030205
resolver
enst
ENSRNOT00065054671
resolver
genesymbol
Mphosph8
resolver
genesymbol_syn
Mpp8
resolver
uniprot
Q4KLM1
resolver
uniprot_entry
MPP8_RAT
resolver
uniprot_sec
Q4KLM1
resolver
amino_acid_sequence
MAAATEENMSVAALVMSVPDNIGRSPEVEGGGAAGEEKDAATKGTVAVGDSEEDGEDVFEVERILDMKCEGGKNLYKVRWKGYTSDDDTWEPEVHLEDCKEVLLEFRKKVAENKAKAVRKDIQKLSLNNDIFEADSDIDQQGDTKEDTSPRKKKKKIKYKEDKSPDDLRKKRAKMGKLKDKFKTELESTSEILGFDVKTKKRILEVKEELKDSKKPKKDEIKETKKTKRADIRDLKIKIREDVKDNRKTKKERYIDSPLESESPNDSFTLEDESEDFLSDNKEKQNVRTAKDKTGQDTVQESIFEKHLDDLISIEEAGTRVRRKKKQPRKFEEPKEIKKLENTNNFLERKMIPKKQRNQDKGRSNPELSKLPSPVFAQTMKSLRLSGEEKGLKSSDLAEEEKERKNEPKEKYQKRYDFDKEEKARKEPKGLKSFKEIRNAFDLFKKTAEEKNDLENNSKREEISLDYKITHDNKTKDKCSLREERNTRDETDTWAYIAAEGDQEVSDSVCQTDESSDGKQPILSLGMDLQLEWMKLEDFQKHLDGEDEPFITANRIPSNLLRDAVKNGDYIAVKVALNSNEEYNLDQEDSTGMTLVMLAAAGGQDDLLRLLITKGAKVNGRQKNGTTALIHAAEKNFLTTVAILLEAGAFVNVQQSNGETALMKACKRGNSDIVRLVIECGADCNILSKHQNSALYFAKQCNNVLVYELLKSHLETLSRVAEETIRDYFESRLALLEPVFPIACHRLCEGPDFSTDFNYMPPQNMPEGSGVLLFIFHANFLGKDVIARLCGPCSVQAVVLNDKFQLPVFLDSHFVYSFSPVAGPNKLFIRLTEAPFAKVKLLIGAYRVQLQ
uniprot
proteins
function
FUNCTION: Heterochromatin component that specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes recruitment of proteins that mediate epigenetic repression. As part of the HUSH complex, promotes epigenetic repression of mobile genetic elements, such as retroviruses and transposable elements: the HUSH complex mainly represses LINE-1 (L1) retrotransposons that are still capable of transposition. Silencing events often occur within introns of transcriptionally active genes, and lead to the down-regulation of host gene expression. MPHOSPH8 mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3, as well as MORC2, a chromatin remodeler that compacts chromatin. The HUSH complex is also involved in the silencing of unintegrated retroviral DNA by being recruited by ZNF638: some part of the retroviral DNA formed immediately after infection remains unintegrated in the host genome and is transcriptionally repressed. As part of the HUSH2 complex, promotes epigenetic repression of interferon-stimulated genes. Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates silencing of E-cadherin (CDH1) and protocadherin genes in the nervous system. {ECO:0000250|UniProtKB:Q99549}.
uniprot
proteins
mass_dalton
96784
uniprot
proteins
post_translational_modification
PTM: Phosphorylated in M (mitotic) phase. Phosphorylation by CDK1 promotes dissociation from chromatin. {ECO:0000250|UniProtKB:Q99549}.
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
851
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q99549}. Chromosome {ECO:0000250|UniProtKB:Q99549}. Note=Detected on heterochromatin. Dissociates from chromatin during interphase and early mitosis. Detected on nucleosomes. {ECO:0000250|UniProtKB:Q99549}.
uniprot
proteins