TMEM8B
entrez
51754
canonical
uniprot
A6NDV4
canonical
ensembl
ENSG00000137103
resolver
ensp
ENSP00000367230
resolver
ensp
ENSP00000367235
resolver
ensp
ENSP00000395810
resolver
ensp
ENSP00000493496
resolver
ensp
ENSP00000622398
resolver
ensp
ENSP00000664924
resolver
ensp
ENSP00000718069
resolver
ensp
ENSP00000718072
resolver
ensp
ENSP00000790452
resolver
ensp
ENSP00000795071
resolver
enst
ENST00000643932
resolver
genesymbol
TMEM8B
resolver
genesymbol_syn
C9orf127
resolver
genesymbol_syn
NGX6
resolver
hgnc
HGNC:21427
resolver
uniprot
A0A2R8Y2M5
resolver
uniprot
B3KQF3
resolver
uniprot
O75539
resolver
uniprot
Q49AB1
resolver
uniprot
Q4KMX5
resolver
uniprot
Q5TCW5
resolver
uniprot
Q9HBY2
resolver
uniprot
Q9P0U7
resolver
uniprot_entry
A0A2R8Y2M5_HUMAN
resolver
uniprot_entry
TMM8B_HUMAN
resolver
uniprot_sec
B3KQF3
resolver
uniprot_sec
O75539
resolver
uniprot_sec
Q49AB1
resolver
uniprot_sec
Q4KMX5
resolver
uniprot_sec
Q5TCW5
resolver
uniprot_sec
Q9HBY2
resolver
uniprot_sec
Q9P0U7
resolver
amino_acid_sequence
MNMPQSLGNQPLPPEPPSLGTPAEGPGTTSPPEHCWPVRPTLRNELDTFSVHFYIFFGPSVALPPERPAVFAMRLLPVLDSGGVLSLELQLNASSVRQENVTVFGCLTHEVPLSLGDAAVTCSKESLAGFLLSVSATTRVARLRIPFPQTGTWFLALRSLCGVGPRFVRCRNATAEVRMRTFLSPCVDDCGPYGQCKLLRTHNYLYAACECKAGWRGWGCTDSADALTYGFQLLSTLLLCLSNLMFLPPVVLAIRSRYVLEAAVYTFTMFFSTFYHACDQPGIVVFCIMDYDVLQFCDFLGSLMSVWVTVIAMARLQPVVKQVLYLLGAMLLSMALQLDRHGLWNLLGPSLFALGILATAWTVRSVRRRHCYPPTWRRWLFYLCPGSLIAGSAVLLYAFVETRDNYFYIHSIWHMLIAGSVGFLLPPRAKTDHGVPSGARARGCGYQLCINEQEELGLVGPGGATVSSICAS
uniprot
proteins
function
FUNCTION: May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion. {ECO:0000269|PubMed:15498789, ECO:0000269|PubMed:15723283, ECO:0000269|PubMed:17270023, ECO:0000269|PubMed:17641538}.
uniprot
proteins
mass_dalton
51941
uniprot
proteins
post_translational_modification
PTM: Isoform 2 is N-glycosylated. {ECO:0000269|PubMed:15498789}.
uniprot
proteins
protein_family
TMEM8 family
uniprot
proteins
pubmed
11565907
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164053
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15498789
uniprot
proteins
pubmed
15723283
uniprot
proteins
pubmed
17270023
uniprot
proteins
pubmed
17641538
uniprot
proteins
sequence_length
472
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane {ECO:0000269|PubMed:17641538}; Multi-pass membrane protein {ECO:0000269|PubMed:17641538}. Cytoplasm {ECO:0000269|PubMed:17641538}. Nucleus {ECO:0000269|PubMed:17641538}. Mitochondrion {ECO:0000269|PubMed:17641538}. Endoplasmic reticulum {ECO:0000269|PubMed:17641538}. Note=Also detected in mitochondrion and endoplasmic reticulum (PubMed:17641538).
uniprot
proteins
transmembrane_region
TRANSMEM 234..254; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 258..277; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 293..313; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 316..336; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 343..363; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 380..400; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 406..426; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins