Cngb3
entrez
30952
canonical
uniprot
Q9JJZ9
canonical
ensembl
ENSMUSG00000056494
resolver
ensp
ENSMUSP00000100064
resolver
enst
ENSMUST00000102999
resolver
genesymbol
Cngb3
resolver
genesymbol_syn
Cng6
resolver
uniprot_entry
CNGB3_MOUSE
resolver
amino_acid_sequence
MLKSLTVKFNKVNPMEGRMEKKLCPNLSSLSQPTIAQGDNQSEKEPLRSRTPITFEKSHSKEDNSTGENSLRDFTPNPDPECRAELTRTMAEMEKTRTGKERPVSFKTKVLETSIINEYTDAHLHNLVERMRERTALYKKTLTEEENFPEVEASSQTAMSTNISPKQENNSKLKEHQDTFSFKPQRVPVKEHLRRMILPRSIDSYTDRVYLLWLLLVTIAYNWNCWLLPVRLVFPCQTPDNKNYWIITDIVCDIIYLCDILLIQPRLQFVRGGEIIVDSNELKRNYRSSTKFRMDVASLLPFEVLYIFFGVNPIFRANRILKYTSFFEFNHHLESIMDKAYVYRVIRTTGYLLFLLHINACVYYWASDYEGIGSTKWVYNGEGNKYLRCFYWAVRTLITIGGLPEPQTSFEIVFQFLNFFSGVFVFSSLIGQMRDVIGAATANQNYFQACMDHIIAYMNKYSIPQSVQYRVRTWLEYTWNSQRILDESNLLENLPTAMQLSIALDINFSIIDKVELFKGCDTQMIYDLLLRLKSTIYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGAQVLVTLKAGSVFGEISLLAKGGGNRRTADVVAHGFANLLTLDKKTLQEILLHYPTSKKLLMKKAKILLSQKGKTTQAIPARPGPAFLFPPKEETPRMLKVLLGNTGKVDLGRLLKGKRKTTTQK
uniprot
proteins
function
FUNCTION: Pore-forming subunit of the cone cyclic nucleotide-gated channel. Mediates cone photoresponses at bright light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade. Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations. {ECO:0000250|UniProtKB:Q9NQW8, ECO:0000269|PubMed:10662822}.
uniprot
proteins
mass_dalton
79722
uniprot
proteins
protein_family
CNGB3 subfamily
uniprot
proteins
protein_family
Cyclic nucleotide-gated cation channel (TC 1.A.1.5) family
uniprot
proteins
pubmed
10662822
uniprot
proteins
pubmed
11764791
uniprot
proteins
sequence_length
694
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Photoreceptor outer segment membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000255}. Cell membrane {ECO:0000250|UniProtKB:Q9NQW8}; Multi-pass membrane protein {ECO:0000255}. Note=Localized in cone outer segment membranes. {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 211..234; /note="Helical; Name=S1"; /evidence="ECO:0000250|UniProtKB:Q9NQW8"; TRANSMEM 242..262; /note="Helical; Name=S2"; /evidence="ECO:0000250|UniProtKB:Q9NQW8"; TRANSMEM 292..309; /note="Helical; Name=S3"; /evidence="ECO:0000250|UniProtKB:Q9NQW8"; TRANSMEM 313..327; /note="Helical; Name=S4"; /evidence="ECO:0000250|UniProtKB:Q9NQW8"; TRANSMEM 341..363; /note="Helical; Name=S5"; /evidence="ECO:0000250|UniProtKB:Q9NQW8"; TRANSMEM 386..412; /note="Helical; Name=P-helix"; /evidence="ECO:0000250|UniProtKB:Q9NQW8"; TRANSMEM 413..437; /note="Helical; Name=S6"; /evidence="ECO:0000250|UniProtKB:Q9NQW8
uniprot
proteins