KLRF1
entrez
51348
canonical
uniprot
Q9NZS2
canonical
ensembl
ENSG00000150045
resolver
ensp
ENSP00000279545
resolver
ensp
ENSP00000346919
resolver
ensp
ENSP00000443054
resolver
ensp
ENSP00000483713
resolver
ensp
ENSP00000659302
resolver
enst
ENST00000537723
resolver
genesymbol
KLRF1
resolver
genesymbol_syn
CLEC5C
resolver
genesymbol_syn
ML
resolver
hgnc
HGNC:13342
resolver
uniprot
A0A0C4DGY9
resolver
uniprot
F6XNZ5
resolver
uniprot
Q4KMT5
resolver
uniprot
Q4KN30
resolver
uniprot
Q96PR2
resolver
uniprot
Q96PR3
resolver
uniprot
Q9NZS1
resolver
uniprot_entry
F6XNZ5_HUMAN
resolver
uniprot_entry
KLRF1_HUMAN
resolver
uniprot_entry
Q4KN30_HUMAN
resolver
uniprot_sec
A0A0C4DGY9
resolver
uniprot_sec
Q4KMT5
resolver
uniprot_sec
Q96PR2
resolver
uniprot_sec
Q96PR3
resolver
uniprot_sec
Q9NZS1
resolver
amino_acid_sequence
MQDEERYMTLNVQSKKRSSAQTSQLTFKDYSVTLHWYKILLGISGTVNGILTLTLISLILLVSQGVLLKCQKGSCSNATQYEDTGDLKVNNGTRRNISNKDLCASRSADQTVLCQSEWLKYQGKCYWFSNEMKSWSDSYVYCLERKSHLLIIHDQLEMAFIQKNLRQLNYVWIGLNFTSLKMTWTWVDGSPIDSKIFFIKGPAKENSCAAIKESKIFSETCSSVFKWICQY
uniprot
proteins
function
FUNCTION: Functions as an activating receptor involved in immunosurveillance upon binding to various ligands displayed at the surface of myeloid cells. Upon interaction with CLEC2B ligand, stimulates NK-cell cytotoxicity and cytokine production leading to the cytolysis of malignant CLEC2B-expressing myeloid cells. Actviation of the common cytotoxicity pathway involves SRC and SYK kinases (PubMed:21149606). {ECO:0000269|PubMed:17057721, ECO:0000269|PubMed:21149606}.
uniprot
proteins
mass_dalton
26563
uniprot
proteins
mutagenesis
MUTAGEN 7; /note="Y->F: Complete loss of cytolysis."; /evidence="ECO:0000269|PubMed:21149606
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Tyr-7; this phosphorylation is required for NKp80/KLRF1-mediated cytotoxicity. {ECO:0000269|PubMed:21149606}.
uniprot
proteins
pubmed
10671213
uniprot
proteins
pubmed
11265639
uniprot
proteins
pubmed
11513955
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16541075
uniprot
proteins
pubmed
17057721
uniprot
proteins
pubmed
21149606
uniprot
proteins
sequence_length
231
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 39..59; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins