Arhgap18
entrez
73910
canonical
uniprot
Q8K0Q5
canonical
ensembl
ENSMUSG00000039031
resolver
ensp
ENSMUSP00000044834
resolver
ensp
ENSMUSP00000234728
resolver
enst
ENSMUST00000039557
resolver
genesymbol
Arhgap18
resolver
uniprot
Q8BP03
resolver
uniprot
Q8R196
resolver
uniprot_entry
RHG18_MOUSE
resolver
uniprot_sec
Q8BP03
resolver
uniprot_sec
Q8R196
resolver
amino_acid_sequence
MNWLSSSSGVVLTAYHPSGKDQVAGDSHVKGGDEATSSRRYGQYTINQEGSTKVPERPPFDRSSSQDSLDESMEAYWTELENIKRSNENRQEGQEAIVVKEPDEGELEEEWLKEAGLSNLFGESIDDPQESILFLSTLTRTQAAAVQKRVETVSQTLRKKNKQHHIRDVRDIFAQQREAQEKPPDDSDLRSVRTNENKGQGKDDQPSSGAVDSKEQISRVPEDTPASETDINLEVSFAEQAVNQKEFSKERTQKISSNDSLPSFRLPKDKTGTTRIGDLAPQDMKKVCSLSLIELTALYDVLGLEFKQQKAVKIKTRDSGLFGIPLTILLEQDQRKVPGTRIPLIFQKLISRIEEGSLETEGLLRIPGAAMRIKNLCQELEAKFYEGTFNWESVKQHDAASLLKLFLRELPQPLLSMEYLKAFQAVQNLPTRKEQLQALNLLVILLPDANRDTLKALLEFLQRVIDNKEKNKMTAGNVAMVMAPNLFMCHTLGLKSSEQREFEMAAGTANVMHLLIRYQKILWTIPKFIVIQVRKQNIENQKKERKAMKKLLKKMAYDREKHEKQDKTANGADVPQGVIRVQAPHLSKVSMAIQLTEELKASDVLARFLSQESGVAQTLKKGEVFLYEIGGNIGERCLDDDTHMKDLYQLNPNAEWVIKSKPV
uniprot
proteins
function
FUNCTION: Rho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state. Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1. Regulates cell shape, spreading, and migration (By similarity). {ECO:0000250|UniProtKB:Q8N392}.
uniprot
proteins
mass_dalton
74930
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21865595
uniprot
proteins
sequence_length
663
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8N392}.
uniprot
proteins