Acvrl1
entrez
11482
canonical
uniprot
Q61288
canonical
ensembl
ENSMUSG00000000530
resolver
ensp
ENSMUSP00000000542
resolver
ensp
ENSMUSP00000112490
resolver
ensp
ENSMUSP00000113297
resolver
ensp
ENSMUSP00000113505
resolver
ensp
ENSMUSP00000113536
resolver
ensp
ENSMUSP00000114027
resolver
ensp
ENSMUSP00000247983
resolver
enst
ENSMUST00000000542
resolver
enst
ENSMUST00000117984
resolver
enst
ENSMUST00000119063
resolver
enst
ENSMUST00000120028
resolver
enst
ENSMUST00000120754
resolver
enst
ENSMUST00000121718
resolver
genesymbol
Acvrl1
resolver
genesymbol_syn
Acvrlk1
resolver
genesymbol_syn
Alk-1
resolver
uniprot
Q61289
resolver
uniprot
Q91YR0
resolver
uniprot_entry
ACVL1_MOUSE
resolver
uniprot_sec
Q61289
resolver
uniprot_sec
Q91YR0
resolver
amino_acid_sequence
MTLGSFRRGLLMLSVAFGLTRGDLAKPSKLVNCTCESPHCKRPFCQGSWCTVVLVREQGRHPQVYRGCGSLNQELCLGRPTEFLNHHCCYRSFCNHNVSLMLEATQTPSEEPEVDAHLPLILGPVLALPVLVALGALGLWRVRRRQEKQRDLHSDLGESSLILKASEQADSMLGDFLDSDCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGSWHGESVAVKIFSSRDEQSWFRETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPQLALRLAVSAACGLAHLHVEIFGTQGKPAIAHRDLKSRNVLVKSNLQCCIADLGLAVMHSQSSDYLDIGNNPRVGTKRYMAPEVLDEHIRTDCFESYKWTDIWAFGLVLWEIARRTIINGIVEDYRPPFYDMVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARLTALRIKKTLQKLSHNPEKPKVIH
uniprot
proteins
ec_number
2.7.11.30
uniprot
proteins
function
FUNCTION: Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. {ECO:0000250|UniProtKB:P37023}.
uniprot
proteins
mass_dalton
56519
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
TGFB receptor subfamily
uniprot
proteins
protein_family
TKL Ser/Thr protein kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7488127
uniprot
proteins
pubmed
7750489
uniprot
proteins
sequence_length
502
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P37023}; Single-pass type I membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 120..140; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins