Slc6a2
entrez
20538
canonical
uniprot
O55192
canonical
ensembl
ENSMUSG00000055368
resolver
ensp
ENSMUSP00000072709
resolver
ensp
ENSMUSP00000129869
resolver
ensp
ENSMUSP00000190989
resolver
ensp
ENSMUSP00000190991
resolver
enst
ENSMUST00000072939
resolver
enst
ENSMUST00000165470
resolver
genesymbol
Slc6a2
resolver
genesymbol_syn
Net
resolver
uniprot
Q6QU62
resolver
uniprot
Q8R2I2
resolver
uniprot_entry
Q8R2I2_MOUSE
resolver
uniprot_entry
SC6A2_MOUSE
resolver
uniprot_sec
Q6QU62
resolver
amino_acid_sequence
MLLARMNPQVQPELGGADPLPEQPLRPCKTADLLVVKERNGVQCLLASQDSDAQPRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHSWNSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVIVVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVLFFLMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTCVVTISTFLLALFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYTYPPWANWVGWGIALSSMILVPAYVIYKFLSIRGSLWERVAYGITPENEHHLVAQRDVRQFQLRHWLAI
uniprot
proteins
function
FUNCTION: Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline), the primary signaling neurotransmitter in the autonomic sympathetic nervous system (PubMed:16269905, PubMed:23580201). Is responsible for norepinephrine reuptake and clearance from the synaptic cleft, thus playing a crucial role in norepinephrine inactivation and homeostasis (PubMed:10769386, PubMed:23580201). Can also mediate sodium- and chloride-dependent transport of dopamine (By similarity). {ECO:0000250|UniProtKB:P23975, ECO:0000269|PubMed:10769386, ECO:0000269|PubMed:16269905, ECO:0000269|PubMed:23580201}.
uniprot
proteins
mass_dalton
69255
uniprot
proteins
mutagenesis
MUTAGEN 457; /note="A->P: Heterozygous knockin mice have tachycardia without a change in blood pressure or baroreceptor sensitivity, reduced brain and sympathetic norepinephrine transport, elevated plasma and urine norepinephrine levels, reduced 3,4-dihydroxyphenylglycol levels and 3,4-dihydroxyphenylglycol:norepinephrine ratios compared with wild-type mice, consistent with a decrease in sympathetic nerve terminal norepinephrine reuptake."; /evidence="ECO:0000269|PubMed:23580201
uniprot
proteins
post_translational_modification
PTM: Palmitoylated. Palmitoylation regulates protein levels and neurotransmitter transport. {ECO:0000250|UniProtKB:P23975}.
uniprot
proteins
protein_family
SLC6A2 subfamily
uniprot
proteins
protein_family
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
uniprot
proteins
pubmed
10769386
uniprot
proteins
pubmed
16269905
uniprot
proteins
pubmed
19545450
uniprot
proteins
pubmed
23580201
uniprot
proteins
pubmed
9603188
uniprot
proteins
sequence_length
617
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P23975}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000269|PubMed:19545450}. Synapse, synaptosome {ECO:0000269|PubMed:23580201}.
uniprot
proteins
transmembrane_region
TRANSMEM 63..88; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q7K4Y6"; TRANSMEM 93..116; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q7K4Y6"; TRANSMEM 136..166; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q7K4Y6"; TRANSMEM 234..254; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q7K4Y6"; TRANSMEM 258..282; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q7K4Y6"; TRANSMEM 307..332; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q7K4Y6"; TRANSMEM 339..362; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q7K4Y6"; TRANSMEM 403..428; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q7K4Y6"; TRANSMEM 444..464; /note="Helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q7K4Y6"; TRANSMEM 466..492; /note="Helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q7K4Y6"; TRANSMEM 523..545; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q7K4Y6"; TRANSMEM 549..569; /note="Helical; Name=12"; /evidence="ECO:0000250|UniProtKB:Q7K4Y6
uniprot
proteins