Sgf29
entrez
75565
canonical
uniprot
Q9DA08
canonical
ensembl
ENSMUSG00000030714
resolver
ensp
ENSMUSP00000032956
resolver
ensp
ENSMUSP00000327225
resolver
enst
ENSMUST00000032956
resolver
genesymbol
Sgf29
resolver
genesymbol_syn
Ccdc101
resolver
uniprot
Q8R0I6
resolver
uniprot_entry
SGF29_MOUSE
resolver
uniprot_sec
Q8R0I6
resolver
amino_acid_sequence
MALVSADSRIAELLTELHQLIKQTQEERSRSEHNLVNIQKTHERMQTENKISPYYRTKLRGLYTTAKTDAEAECNILRKALDKIAEIKSLLEERRIAAKIAGLYNDSEPPRKTMRRGVLMTLLQQSAMTLPLWIGKPGDKPPPLCGAIPASGDYVAKPGDKVAARVKAVEGDEQWILAEVVSYSHATNKYEVDDIDEEGKERHTLSRRRIIPLPQWKANPETDPEALFQKEQLVLALYPQTTCFYRALIHTPPQRPQDDYSVLFEDTSYADGYSPPLNVAQRYVVACKEPKKK
uniprot
proteins
function
FUNCTION: Chromatin reader component of some histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes (By similarity). SGF29 specifically recognizes and binds methylated 'Lys-4' of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3) (By similarity). In the SAGA-type complexes, SGF29 is required to recruit complexes to H3K4me (By similarity). Involved in the response to endoplasmic reticulum (ER) stress by recruiting the SAGA complex to H3K4me, thereby promoting histone H3 acetylation and cell survival (By similarity). Also binds non-histone proteins that are methylated on Lys residues: specifically recognizes and binds CGAS monomethylated on 'Lys-491' (PubMed:35210392). {ECO:0000250|UniProtKB:Q96ES7, ECO:0000269|PubMed:35210392}.
uniprot
proteins
mass_dalton
33298
uniprot
proteins
protein_family
SGF29 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
35210392
uniprot
proteins
sequence_length
293
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P0C606}.
uniprot
proteins