STEAP4
entrez
79689
canonical
uniprot
Q687X5
canonical
ensembl
ENSG00000127954
resolver
ensp
ENSP00000305545
resolver
ensp
ENSP00000369419
resolver
ensp
ENSP00000549164
resolver
genesymbol
STEAP4
resolver
genesymbol_syn
STAMP2
resolver
genesymbol_syn
TNFAIP9
resolver
hgnc
HGNC:21923
resolver
uniprot
Q658Q9
resolver
uniprot
Q687X4
resolver
uniprot
Q8WWB0
resolver
uniprot
Q9H5R1
resolver
uniprot_entry
STEA4_HUMAN
resolver
uniprot_sec
Q658Q9
resolver
uniprot_sec
Q687X4
resolver
uniprot_sec
Q8WWB0
resolver
uniprot_sec
Q9H5R1
resolver
amino_acid_sequence
MEKTCIDALPLTMNSSEKQETVCIFGTGDFGRSLGLKMLQCGYSVVFGSRNPQKTTLLPSGAEVLSYSEAAKKSGIIIIAIHREHYDFLTELTEVLNGKILVDISNNLKINQYPESNAEYLAHLVPGAHVVKAFNTISAWALQSGALDASRQVFVCGNDSKAKQRVMDIVRNLGLTPMDQGSLMAAKEIEKYPLQLFPMWRFPFYLSAVLCVFLFFYCVIRDVIYPYVYEKKDNTFRMAISIPNRIFPITALTLLALVYLPGVIAAILQLYRGTKYRRFPDWLDHWMLCRKQLGLVALGFAFLHVLYTLVIPIRYYVRWRLGNLTVTQAILKKENPFSTSSAWLSDSYVALGILGFFLFVLLGITSLPSVSNAVNWREFRFVQSKLGYLTLILCTAHTLVYGGKRFLSPSNLRWYLPAAYVLGLIIPCTVLVIKFVLIMPCVDNTLTRIRQGWERNSKH
uniprot
proteins
ec_number
1.16.1.-
uniprot
proteins
function
FUNCTION: Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane. Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (PubMed:30337524). Can also reduce Cu(2+) to Cu(1+) (By similarity). Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance (PubMed:18381574, PubMed:18430367). Involved in inflammatory arthritis, through the regulation of inflammatory cytokines (PubMed:19660107). Inhibits anchorage-independent cell proliferation (PubMed:19787193). {ECO:0000250|UniProtKB:Q923B6, ECO:0000269|PubMed:18381574, ECO:0000269|PubMed:18430367, ECO:0000269|PubMed:19660107, ECO:0000269|PubMed:19787193, ECO:0000269|PubMed:30337524}.
uniprot
proteins
mass_dalton
51981
uniprot
proteins
mutagenesis
MUTAGEN 138; /note="S->Q: Strongly reduced enzyme activity. No effect on trimerization and on heme binding."; /evidence="ECO:0000269|PubMed:30337524
uniprot
proteins
protein_family
STEAP family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15897894
uniprot
proteins
pubmed
16227996
uniprot
proteins
pubmed
17974005
uniprot
proteins
pubmed
18381574
uniprot
proteins
pubmed
18430367
uniprot
proteins
pubmed
19159218
uniprot
proteins
pubmed
19289123
uniprot
proteins
pubmed
19660107
uniprot
proteins
pubmed
19787193
uniprot
proteins
pubmed
30337524
uniprot
proteins
sequence_length
459
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15897894, ECO:0000269|PubMed:18430367}; Multi-pass membrane protein {ECO:0000269|PubMed:30337524}. Golgi apparatus membrane {ECO:0000269|PubMed:15897894}; Multi-pass membrane protein {ECO:0000269|PubMed:30337524}. Early endosome membrane {ECO:0000269|PubMed:15897894}; Multi-pass membrane protein {ECO:0000269|PubMed:30337524}.
uniprot
proteins
transmembrane_region
TRANSMEM 202..224; /note="Helical"; /evidence="ECO:0000269|PubMed:30337524"; TRANSMEM 236..256; /note="Helical"; /evidence="ECO:0000269|PubMed:30337524"; TRANSMEM 293..313; /note="Helical"; /evidence="ECO:0000269|PubMed:30337524"; TRANSMEM 342..362; /note="Helical"; /evidence="ECO:0000269|PubMed:30337524"; TRANSMEM 381..401; /note="Helical"; /evidence="ECO:0000269|PubMed:30337524"; TRANSMEM 419..439; /note="Helical"; /evidence="ECO:0000269|PubMed:30337524
uniprot
proteins