Smpdl3b
entrez
100340
canonical
uniprot
P58242
canonical
ensembl
ENSMUSG00000028885
resolver
ensp
ENSMUSP00000030709
resolver
ensp
ENSMUSP00000241796
resolver
enst
ENSMUST00000030709
resolver
genesymbol
Smpdl3b
resolver
genesymbol_syn
Asml3b
resolver
uniprot
Q3TLX9
resolver
uniprot_entry
ASM3B_MOUSE
resolver
uniprot_entry
Q3TLX9_MOUSE
resolver
amino_acid_sequence
MTLLGWLIFLAPWGVAGAQLGRFWHISDLHLDPNYTVSKDPLQVCPSAGSQPVLNAGPWGDYLCDSPWALINSSLYAMKEIEPKPDFILWTGDDTPHVPNESLGEAAVLAIVERLTNLIKEVFPDTKVYAALGNHDFHPKNQFPAQSNRIYNQVAELWRPWLSNESYALFKRGAFYSEKLPGPSRAGRVVVLNTNLYYSNNEQTAGMADPGEQFRWLGDVLSNASRDGEMVYVIGHVPPGFFEKTQNKAWFRESFNEEYLKVIQKHHRVIAGQFFGHHHTDSFRMFYDNTGAPINVMFLTPGVTPWKTTLPGVVDGANNPGIRIFEYDRATLNLKDLVTYFLNLRQANVQETPRWEQEYRLTEAYQVPDASVSSMHTALTRIASEPHILQRYYVYNSVSYNHLTCEDSCRIEHVCAIQHVAFNTYATCLHGLGAKLVPGFLLILTLLPSLHVLEVL
uniprot
proteins
ec_number
3.1.4.-
uniprot
proteins
function
FUNCTION: Lipid-modulating phosphodiesterase. Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity (PubMed:26095358). Acts as a negative regulator of Toll-like receptor signaling (PubMed:26095358, PubMed:27687724). Has in vitro phosphodiesterase activity, but the physiological substrate is unknown (PubMed:26095358, PubMed:27687724). Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro) (PubMed:27687724). {ECO:0000269|PubMed:26095358, ECO:0000269|PubMed:27687724}.
uniprot
proteins
mass_dalton
51600
uniprot
proteins
mutagenesis
MUTAGEN 135; /note="H->A: Reduced phosphodiesterase activity. Decreases inhibition of innate immune responses."; /evidence="ECO:0000269|PubMed:26095358, ECO:0000269|PubMed:27687724"; MUTAGEN 140..141; /note="KN->MA: Reduced phosphodiesterase activity. Decreases inhibition of innate immune responses."; /evidence="ECO:0000269|PubMed:27687724"; MUTAGEN 198..200; /note="YSN->FSA: No effect on enzyme activity and innate immune responses."; /evidence="ECO:0000269|PubMed:27687724"; MUTAGEN 307..315; /note="KTTLPGVVD->SG: Increased phosphodiesterase activity (in vitro)."; /evidence="ECO:0000269|PubMed:27687724
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:26095358}.
uniprot
proteins
protein_family
Acid sphingomyelinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19349973
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
26095358
uniprot
proteins
pubmed
27687724
uniprot
proteins
sequence_length
456
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Cell membrane; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:26095358}.
uniprot
proteins