Pigw
entrez
378774
canonical
uniprot
Q7TSN4
canonical
ensembl
ENSRNOG00000027857
resolver
ensp
ENSRNOP00000060195
resolver
genesymbol
Pigw
resolver
uniprot_entry
PIGW_RAT
resolver
amino_acid_sequence
MSQKQLKEAFVSNLSGTSVLEVTQGLCFPAFCILCRGLLIIFSQHLCSFLHTWTTQFFMDFVVLIVPLVITLTVLSSFILLENLTVILCGAWLLYQIYHRRTCYAKVPVQKVFASFLKISLESEYNPAITCYRVINSVFTAIAILAVDFPLFPRRFAKTELYGTGAMDFGVGGFIFGAAMVCPEVRRKYTEGSRFNHLRKSLYSVWPLVFLGMGRLVIIKSIGYQEHSTEYGVHWNFFFTIIVVKLITSLLLIIFPLNKSWIVAISITVLYQLALDFTPLKGIILYGTDGRGTRVGLLNANREGIISTLGYVAIYMAGVQTGFYVFKRRAQVRDWIKATCWVFSVAVGFFISLNIVQVNVEAVSRRMANLAFCLWVVASSLMLLSCLLLSGIVLSFAKFLIKGALVPCSWKLIQSATTNRQSESLIVEAEKNKPSFCLITALNRNQLFFFLLSNVATGLINLTVDTLHTGAFWTLAVLSIYMFANCLVIYVLDLQGKTIKFW
uniprot
proteins
ec_number
2.3.-.-
uniprot
proteins
function
FUNCTION: Acyltransferase that catalyzes the acyl transfer from an acyl-CoA at the 2-OH position of the inositol ring of a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol (glucosaminyl phosphatidylinositol, GlcN-PI) to generate a 2-acyl-6-alpha-D-glucosaminyl-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol (glucosaminyl acyl phosphatidylinositol, GlcN-(acyl)PI) and participates in the fourth step of GPI-anchor biosynthesis (PubMed:14517336). Required for the transport of GPI-anchored proteins to the plasma membrane (By similarity). Acylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins (PubMed:14517336). {ECO:0000250|UniProtKB:Q7Z7B1, ECO:0000269|PubMed:14517336}.
uniprot
proteins
mass_dalton
56443
uniprot
proteins
pathway_participation
PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis. {ECO:0000269|PubMed:14517336}.
uniprot
proteins
protein_family
PIGW family
uniprot
proteins
pubmed
14517336
uniprot
proteins
sequence_length
502
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:14517336}; Multi-pass membrane protein {ECO:0000269|PubMed:14517336}.
uniprot
proteins
transmembrane_region
TRANSMEM 22..42; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 49..71; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 75..97; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 132..152; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 161..181; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 202..222; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 237..257; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 260..280; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 305..325; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 338..358; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 374..394; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 447..467; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 472..492; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins