DNPH1
entrez
10591
canonical
uniprot
O43598
canonical
ensembl
ENSG00000112667
resolver
ensp
ENSP00000230431
resolver
ensp
ENSP00000377556
resolver
genesymbol
DNPH1
resolver
genesymbol_syn
C6orf108
resolver
genesymbol_syn
RCL
resolver
hgnc
HGNC:21218
resolver
uniprot
B2LUJ9
resolver
uniprot_entry
DNPH1_HUMAN
resolver
uniprot_sec
B2LUJ9
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by AMP and GMP. {ECO:0000269|PubMed:37142196}.
uniprot
proteins
amino_acid_sequence
MAAAMVPGRSESWERGEPGRPALYFCGSIRGGREDRTLYERIVSRLRRFGTVLTEHVAAAELGARGEEAAGGDRLIHEQDLEWLQQADVVVAEVTQPSLGVGYELGRAVAFNKRILCLFRPQSGRVLSAMIRGAADGSRFQVWDYEEGEVEALLDRYFEADPPGQVAASPDPTT
uniprot
proteins
ec_number
3.2.2.-
uniprot
proteins
function
FUNCTION: Part of a nucleotide salvage pathway that eliminates epigenetically modified 5-hydroxymethyl-dCMP (hmdCMP) in a two-step process entailing deamination to cytotoxic 5-hydroxymethyl-dUMP (hmdUMP), followed by its hydrolysis into 5-hydroxymethyluracil (hmU) and 2-deoxy-D-ribose 5-phosphate (deoxyribosephosphate) (PubMed:33833118). Catalyzes the second step in that pathway, the hydrolysis of the N-glycosidic bond in hmdUMP, degrading this cytotoxic nucleotide to avoid its genomic integration (PubMed:33833118). {ECO:0000269|PubMed:33833118}.
uniprot
proteins
mass_dalton
19108
uniprot
proteins
mutagenesis
MUTAGEN 104; /note="E->Q: Loss of deoxyribonucleoside 5'-monophosphate N-glycosidase activity."; /evidence="ECO:0000269|PubMed:33833118
uniprot
proteins
protein_family
2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family
uniprot
proteins
pubmed
14574404
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17081983
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18726892
uniprot
proteins
pubmed
19413330
uniprot
proteins
pubmed
19690332
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
22223895
uniprot
proteins
pubmed
22814378
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24260472
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
25108359
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
33833118
uniprot
proteins
pubmed
37142196
uniprot
proteins
pubmed
9271375
uniprot
proteins
sequence_length
174
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18726892}. Nucleus {ECO:0000269|PubMed:9271375}.
uniprot
proteins