Slc39a9
entrez
314275
canonical
uniprot
Q3KR82
canonical
ensembl
ENSRNOG00000005052
resolver
ensp
ENSRNOP00000075500
resolver
ensp
ENSRNOP00000102942
resolver
ensp
ENSRNOP00000108667
resolver
enst
ENSRNOT00000089313
resolver
enst
ENSRNOT00000141674
resolver
enst
ENSRNOT00000163023
resolver
genesymbol
Slc39a9
resolver
genesymbol_syn
Zip9
resolver
uniprot
A0A0G2KAR8
resolver
uniprot
A0ABK0LLX7
resolver
uniprot_entry
A0A0G2KAR8_RAT
resolver
uniprot_entry
A0ABK0LLX7_RAT
resolver
uniprot_entry
S39A9_RAT
resolver
amino_acid_sequence
MDDFLSISLLSLAMLVGCYVAGIIPLAVNFSEERLKLVTVLGAGLLCGTALAVIVPEGVHALYEEVLEGKHHQASEAKQNVIASDKAAEISVVHEHEHSHDHTQLHAYIGVSLVLGFVFMLLVDQIGSSHVHSTDDPESARPSSSKITTTLGLVVHAAADGVALGAAASTSQTSVQLIVFVAIMLHKAPAAFGLVSFLMHAGLERNRIRKHLLVFALAAPAMSMLTYLGLSKSSKEALSEVNATGVAMLFSAGTFLYVATVHVLPEDTSTNQSGSSLSPRPLPSGKN
uniprot
proteins
function
FUNCTION: Transports zinc ions across cell and organelle membranes into the cytoplasm and regulates intracellular zinc homeostasis. Participates in the zinc ions efflux out of the secretory compartments. Regulates intracellular zinc level, resulting in the enhancement of AKT1 and MAPK3/MAPK1 (Erk1/2) phosphorylation in response to the BCR activation (By similarity). Also functions as a membrane androgen receptor that mediates, through a G protein, the non-classical androgen signaling pathway, characterized by the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1 or ATF1 (PubMed:27164415, PubMed:35625396). This pathway contributes to CLDN1 and CLDN5 expression and tight junction formation between adjacent Sertoli cells (PubMed:27164415, PubMed:35625396). Mediates androgen-induced vascular endothelial cell proliferation through activation of an inhibitory G protein leading to the AKT1 and MAPK3/MAPK1 (Erk1/2) activation which in turn modulate inhibition (phosphorylation) of GSK3B and CCND1 transcription. Moreover, has dual functions as a membrane-bound androgen receptor and as an androgen-dependent zinc transporter both of which are mediated through an inhibitory G protein (Gi) that mediates both MAP kinase and zinc signaling leading to the androgen-dependent apoptotic process (By similarity). {ECO:0000250|UniProtKB:Q9NUM3, ECO:0000269|PubMed:27164415, ECO:0000269|PubMed:35625396}.
uniprot
proteins
mass_dalton
30177
uniprot
proteins
protein_family
ZIP transporter (TC 2.A.5) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
27164415
uniprot
proteins
pubmed
35625396
uniprot
proteins
sequence_length
287
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:Q9NUM3}. Cell membrane {ECO:0000250|UniProtKB:Q9NUM3}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q9NUM3}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q9NUM3}. Mitochondrion {ECO:0000250|UniProtKB:Q9NUM3}. Nucleus {ECO:0000250|UniProtKB:Q9NUM3}.
uniprot
proteins
transmembrane_region
TRANSMEM 4..24; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 35..55; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 107..127; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 147..167; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 177..197; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 211..231; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 245..265; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins