Glul
entrez
14645
canonical
uniprot
P15105
canonical
ensembl
ENSMUSG00000026473
resolver
ensp
ENSMUSP00000083375
resolver
ensp
ENSMUSP00000160105
resolver
ensp
ENSMUSP00000160106
resolver
ensp
ENSMUSP00000160107
resolver
enst
ENSMUST00000086199
resolver
enst
ENSMUST00000381746
resolver
enst
ENSMUST00000381747
resolver
enst
ENSMUST00000381748
resolver
genesymbol
Glul
resolver
genesymbol_syn
Glns
resolver
uniprot
Q3TRK7
resolver
uniprot
Q64432
resolver
uniprot
Q91VC6
resolver
uniprot_entry
GLNA_MOUSE
resolver
uniprot_sec
Q3TRK7
resolver
uniprot_sec
Q64432
resolver
uniprot_sec
Q91VC6
resolver
activity_regulation
ACTIVITY REGULATION: Glutamine synthetase activity is inhibited by methionine sulfoximine (MSO). {ECO:0000250|UniProtKB:P15104}.
uniprot
proteins
amino_acid_sequence
MATSASSHLNKGIKQMYMSLPQGEKVQAMYIWVDGTGEGLRCKTRTLDCEPKCVEELPEWNFDGSSTFQSEGSNSDMYLHPVAMFRDPFRKDPNKLVLCEVFKYNRKPAETNLRHICKRIMDMVSNQHPWFGMEQEYTLMGTDGHPFGWPSNGFPGPQGPYYCGVGADKAYGRDIVEAHYRACLYAGVKITGTNAEVMPAQWEFQIGPCEGIRMGDHLWIARFILHRVCEDFGVIATFDPKPIPGNWNGAGCHTNFSTKAMREENGLKCIEEAIDKLSKRHQYHIRAYDPKGGLDNARRLTGFHETSNINDFSAGVANRGASIRIPRTVGQEKKGYFEDRRPSANCDPYAVTEAIVRTCLLNETGDEPFQYKN
uniprot
proteins
ec_number
2.3.1.225
uniprot
proteins
ec_number
6.3.1.2
uniprot
proteins
function
FUNCTION: Glutamine synthetase that catalyzes the ATP-dependent conversion of glutamate and ammonia to glutamine (PubMed:39541460). Its role depends on tissue localization: in the brain, it regulates the levels of toxic ammonia and converts neurotoxic glutamate to harmless glutamine, whereas in the liver, it is one of the enzymes responsible for the removal of ammonia (PubMed:25870278). Plays a key role in ammonium detoxification during erythropoiesis: the glutamine synthetase activity is required to remove ammonium generated by porphobilinogen deaminase (HMBS) during heme biosynthesis to prevent ammonium accumulation and oxidative stress (PubMed:39541460). Essential for proliferation of fetal skin fibroblasts (By similarity). Independently of its glutamine synthetase activity, required for endothelial cell migration during vascular development (PubMed:30158707). Involved in angiogenesis by regulating membrane localization and activation of the GTPase RHOJ, possibly by promoting RHOJ palmitoylation (By similarity). May act as a palmitoyltransferase for RHOJ: able to autopalmitoylate and then transfer the palmitoyl group to RHOJ (By similarity). Plays a role in ribosomal 40S subunit biogenesis (By similarity). Through the interaction with BEST2, inhibits BEST2 channel activity by affecting the gating at the aperture in the absence of intracellular L-glutamate, but sensitizes BEST2 to intracellular L-glutamate, which promotes the opening of BEST2 and thus relieves its inhibitory effect on BEST2 (By similarity). {ECO:0000250|UniProtKB:P15104, ECO:0000269|PubMed:25870278, ECO:0000269|PubMed:30158707, ECO:0000269|PubMed:39541460}.
uniprot
proteins
mass_dalton
42120
uniprot
proteins
post_translational_modification
PTM: Acetylated by EP300/p300; acetylation is stimulated by increased glutamine levels and promotes ubiquitin-mediated proteasomal degradation. {ECO:0000250|UniProtKB:P15104}.; PTM: Palmitoylated; undergoes autopalmitoylation. {ECO:0000250|UniProtKB:P15104}.; PTM: Ubiquitinated by ZNRF1 (PubMed:20107048). Ubiquitinated by the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex called CRL4(CRBN), leading to proteasomal degradation (By similarity). {ECO:0000250|UniProtKB:P15104, ECO:0000269|PubMed:20107048}.
uniprot
proteins
protein_family
Glutamine synthetase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16323283
uniprot
proteins
pubmed
17557305
uniprot
proteins
pubmed
18034455
uniprot
proteins
pubmed
20107048
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2475638
uniprot
proteins
pubmed
25870278
uniprot
proteins
pubmed
30158707
uniprot
proteins
pubmed
39541460
uniprot
proteins
sequence_length
373
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:P15104}. Microsome {ECO:0000250|UniProtKB:P09606}. Mitochondrion {ECO:0000250|UniProtKB:P09606}. Cell membrane {ECO:0000250|UniProtKB:P15104}; Lipid-anchor {ECO:0000250|UniProtKB:P15104}. Note=Mainly localizes in the cytosol, with a fraction associated with the cell membrane. {ECO:0000250|UniProtKB:P15104}.
uniprot
proteins