Lyplal1
entrez
226791
canonical
uniprot
Q3UFF7
canonical
ensembl
ENSMUSG00000039246
resolver
ensp
ENSMUSP00000048229
resolver
enst
ENSMUST00000045388
resolver
genesymbol
Lyplal1
resolver
uniprot
E9QLB2
resolver
uniprot
Q8R065
resolver
uniprot_entry
E9QLB2_MOUSE
resolver
uniprot_entry
LYPL1_MOUSE
resolver
uniprot_sec
Q8R065
resolver
amino_acid_sequence
MAAVPSAVHLPRCVVSPTGRHSASLIFLHGSGHSGQGQREWIKHVLNQDLTFQHIKIIYPTAPSRPYTPLKGGLSNVWFDRFKISMDCPEHLESIDSMCQVLSGLIDEEVKTGIQKSRILIGGFSMGGCMAMHLAYRSHPDVAGVFVLSGFLNKASVVYQDLQQGGRMLPELFQCHGSADNLVLHAWGKETNSKLKSLGVSTTFHSLPNLNHELNKTELEKLKSWILTRLPGETDGQSE
uniprot
proteins
ec_number
3.1.2.22
uniprot
proteins
function
FUNCTION: Palmitoyl thioesterase that catalyzes depalmitoylation of CGAS and KCNMA1. Acts as a regulator of innate immunity by mediating depalmitoylation of CGAS, thereby preventing CGAS homodimerization and cyclic GMP-AMP synthase activity. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site. {ECO:0000250|UniProtKB:Q5VWZ2}.
uniprot
proteins
mass_dalton
26354
uniprot
proteins
protein_family
AB hydrolase 2 family
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
239
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250|UniProtKB:Q5VWZ2}.
uniprot
proteins