Dmtf1
entrez
23857
canonical
uniprot
Q8CE22
canonical
ensembl
ENSMUSG00000042508
resolver
ensp
ENSMUSP00000071815
resolver
ensp
ENSMUSP00000092627
resolver
ensp
ENSMUSP00000188408
resolver
ensp
ENSMUSP00000188410
resolver
ensp
ENSMUSP00000188418
resolver
ensp
ENSMUSP00000188437
resolver
genesymbol
Dmtf1
resolver
genesymbol_syn
Dmp1
resolver
uniprot
P70413
resolver
uniprot
Q3TUR9
resolver
uniprot
Q80VR8
resolver
uniprot
Q8BQX6
resolver
uniprot
Q8CA56
resolver
uniprot
Q8CCZ0
resolver
uniprot_entry
DMTF1_MOUSE
resolver
uniprot_sec
P70413
resolver
uniprot_sec
Q3TUR9
resolver
uniprot_sec
Q80VR8
resolver
uniprot_sec
Q8BQX6
resolver
uniprot_sec
Q8CA56
resolver
uniprot_sec
Q8CCZ0
resolver
amino_acid_sequence
MSTVEEDSDTVTVETVNSVTFTQDTDGNLILHCPQNDPDEVDSEDSTEPPHKRLCLSSEDDQSIDDATPCISVVALPLSENDQSFEVTMTATTEVADDELSEGTVTQIQILQNDQLDEISPLGTEEVSAVSQAWFTTKEDKDSLTNKGHKWKQGMWSKEEIDILMNNIERYLKARGIKDATEIIFEMSKDERKDFYRTIAWGLNRPLFAVYRRVLRMYDDRNHVGKYTPEEIEKLKELRIKHGNDWATIGAALGRSASSVKDRCRLMKDTCNTGKWTEEEEKRLAEVVHELTSTEPGDIVTQGVSWAAVAERVGTRSEKQCRSKWLNYLNWKQSGGTEWTKEDEINLILRIAELDVADENDINWDLLAEGWSSVRSPQWLRSKWWTIKRQIANHKDVSFPVLIKGLKQLHENQKNNPVLLENKSGSGVPNSNCNSSVQHVQIRVARLEDNTAISPSPMAALQIPVQITHVSSTDSPAASVDSETITLNSGTLQTFEILPSFHLQPTGTPGTYLLQTSSSQGLPLTLTTNPTVTLAAAAPASPEQIIVHALSPEHLLNTSDNVTVQCHTPRVIIQTVATEDITSSLSQEELTVDSDLHSSDFPEPPDALEADTFPDEIPRPKMTIQPSFNNAHVSKFSDQNSTELMNSVMVRTEEEIADTDLKQEEPPSDLASAYVTEDLESPTIVHQVHQTIDDETILIVPSPHGFIQASDVIDTESVLPLTTLTDPIFQHHQEASNIIGSSLGSPVSEDSKDVEDLVNCH
uniprot
proteins
function
FUNCTION: Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest. May also cooperate with MYB to activate transcription of the ANPEP gene. Binds to the consensus sequence 5'-CCCG[GT]ATGT-3'. {ECO:0000269|PubMed:10097151, ECO:0000269|PubMed:10898794, ECO:0000269|PubMed:11711428, ECO:0000269|PubMed:15601844, ECO:0000269|PubMed:17936562, ECO:0000269|PubMed:8887674, ECO:0000269|PubMed:9488476, ECO:0000269|PubMed:9786929}.
uniprot
proteins
mass_dalton
84644
uniprot
proteins
mutagenesis
MUTAGEN 319; /note="K->E: Abrogates DNA-binding."; /evidence="ECO:0000269|PubMed:9488476, ECO:0000269|PubMed:9786929
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by the cyclin-D2/CDK4, cyclin-D3/CDK4 and cyclin-D2/CDK6 complexes and to a lesser extent by the cyclin-D1/CDK4 complex. {ECO:0000269|PubMed:8887674, ECO:0000269|PubMed:9488476}.
uniprot
proteins
protein_family
DMTF1 family
uniprot
proteins
pubmed
10097151
uniprot
proteins
pubmed
10898794
uniprot
proteins
pubmed
11711428
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15601844
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16878159
uniprot
proteins
pubmed
17546045
uniprot
proteins
pubmed
17936562
uniprot
proteins
pubmed
8887674
uniprot
proteins
pubmed
9488476
uniprot
proteins
pubmed
9786929
uniprot
proteins
sequence_length
761
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00625, ECO:0000269|PubMed:10097151, ECO:0000269|PubMed:16878159, ECO:0000269|PubMed:17936562, ECO:0000269|PubMed:9488476}.
uniprot
proteins