Ffar1
entrez
233081
canonical
uniprot
Q76JU9
canonical
ensembl
ENSMUSG00000044453
resolver
ensp
ENSMUSP00000055564
resolver
enst
ENSMUST00000052700
resolver
genesymbol
Ffar1
resolver
genesymbol_syn
Gpr40
resolver
uniprot
A2RS88
resolver
uniprot
Q8K3T5
resolver
uniprot_entry
FFAR1_MOUSE
resolver
uniprot_sec
A2RS88
resolver
uniprot_sec
Q8K3T5
resolver
activity_regulation
ACTIVITY REGULATION: Is also activated by synthetic agonists, such as AM-8182, AM-6331 and TAK-875 (fasiglifam). AM-8182 is a full agonist, while AM-6331 and TAK-875 (fasiglifam) are partial agonists that potentiate the activity of the endogenous ligands, such as alpha-linolenic acid and gamma-linolenic acid. {ECO:0000269|PubMed:23403053, ECO:0000269|PubMed:24130766}.
uniprot
proteins
amino_acid_sequence
MDLPPQLSFALYVSAFALGFPLNLLAIRGAVSHAKLRLTPSLVYTLHLGCSDLLLAITLPLKAVEALASGAWPLPLPFCPVFALAHFAPLYAGGGFLAALSAGRYLGAAFPFGYQAIRRPRYSWGVCVAIWALVLCHLGLALGLETSGSWLDNSTSSLGINIPVNGSPVCLEAWDPDSARPARLSFSILLFFLPLVITAFCYVGCLRALVRSGLSHKRKLRAAWVAGGALLTLLLCLGPYNASNVASFINPDLGGSWRKLGLITGAWSVVLNPLVTGYLGTGPGRGTICVTRTQRGTIQK
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for medium and long chain saturated and unsaturated fatty acids that plays an important role in glucose homeostasis. Fatty acid binding increases glucose-stimulated insulin secretion, and may also enhance the secretion of glucagon-like peptide 1 (GLP-1). May also play a role in bone homeostasis; receptor signaling activates pathways that inhibit osteoclast differentiation (PubMed:23335512). Ligand binding leads to a conformation change that triggers signaling via G proteins that activate phospholipase C, leading to an increase of the intracellular calcium concentration. Seems to act through a G(q) and G(i)-mediated pathway. Mediates the anti-inflammatory effects of omega-3 polyunsaturated fatty acids (PUFAs) via inhibition of NLRP3 inflammasome activation. {ECO:0000250|UniProtKB:O14842, ECO:0000269|PubMed:12629551, ECO:0000269|PubMed:16044321, ECO:0000269|PubMed:17395749, ECO:0000269|PubMed:18559658, ECO:0000269|PubMed:23335512, ECO:0000269|PubMed:23403053, ECO:0000269|PubMed:24130766}.
uniprot
proteins
mass_dalton
31804
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12496284
uniprot
proteins
pubmed
12629551
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16044321
uniprot
proteins
pubmed
17395749
uniprot
proteins
pubmed
18559658
uniprot
proteins
pubmed
23335512
uniprot
proteins
pubmed
23403053
uniprot
proteins
pubmed
24130766
uniprot
proteins
sequence_length
300
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16044321, ECO:0000269|PubMed:24130766}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 9..31; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:O14842, ECO:0000255"; TRANSMEM 42..64; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:O14842, ECO:0000255"; TRANSMEM 80..101; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:O14842, ECO:0000255"; TRANSMEM 122..142; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:O14842, ECO:0000255"; TRANSMEM 179..200; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:O14842, ECO:0000255"; TRANSMEM 224..248; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:O14842, ECO:0000255"; TRANSMEM 257..279; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:O14842, ECO:0000255
uniprot
proteins