Grb10
entrez
498416
canonical
uniprot
P0CE43
canonical
ensembl
ENSRNOG00000004290
resolver
ensp
ENSRNOP00000048487
resolver
ensp
ENSRNOP00000070674
resolver
ensp
ENSRNOP00000099840
resolver
ensp
ENSRNOP00000100101
resolver
enst
ENSRNOT00000044726
resolver
enst
ENSRNOT00000085175
resolver
enst
ENSRNOT00000153825
resolver
enst
ENSRNOT00000165114
resolver
genesymbol
Grb10
resolver
uniprot
A0A0G2JYJ1
resolver
uniprot
A0A9M1XG80
resolver
uniprot
A0ABK0L5V8
resolver
uniprot
A0ABK0LAV8
resolver
uniprot_entry
A0A0G2JYJ1_RAT
resolver
uniprot_entry
A0A9M1XG80_RAT
resolver
uniprot_entry
A0ABK0L5V8_RAT
resolver
uniprot_entry
A0ABK0LAV8_RAT
resolver
uniprot_entry
GRB10_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Phosphorylation by mTORC1 stabilizes and activates GRB10 constituting a feedback pathway by which mTORC1 inhibits INSR-dependent signaling. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MNNDINSSVESLNSACNMQSDTDTVPLLENGQSASNQPSASSSRGQPQASPRQKMQRSQPVHIQPLRRLQEEDQQLRTSSLPAIPNPFPELAGGAPGSPPSVAPSSLPPPPSQPPAKHFPPGFQLAKLTRPGLWTKTTARFSKRQPKNQCQTDTANAVSRIPTSQMEKLRLRKDVKVFSEDGTSKVVEILTDMTARDLCQLLVYKSHCVDDNSWTLVEHHPQLGLERCLEDHEIVVQVESTMPSESKFLFRKNYAKYEFFKNPVNFFPDQMVTWCQQSNGGQAQLLQNFLNSSSCPEIQGFLQVKEVGRKSWKKLYVCLRRSGLYYSTKGTSKEPRHLQLLADLEESSIFYLIAGKKQYNAPNEHGMCIKPNKAKIEMKELRLLCAEDEQIRTCWMTAFRLLKYGMLLYQNYRIPQQRKGLAPPFNAPMRSVSENSLVAMDFSGQIGRVIDNPAEAQSAALEEGHAWRKRSTRMNILSSQSPLHPSTLNSVIHRTQHWFHGRISREESHRIIKQQGLVDGLFLLRDSQSNPKAFVLTLCHQQKIRNFQILPCEDDGQTFFTLDDGNTKFSDLIQLVDFYQLNKGVLPCKLKHHCIRVAL
uniprot
proteins
function
FUNCTION: Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. A similar role in the mediation of ubiquitination also has been suggested with INSR. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2 (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
67882
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on serine residues upon EGF, FGF and PDGF stimulation. {ECO:0000250}.
uniprot
proteins
protein_family
GRB7/10/14 family
uniprot
proteins
sequence_length
599
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=When complexed with NEDD4 and IGF1R, follows IGF1R internalization, remaining associated with early endosomes. Uncouples from IGF1R-containing endosomes before the sorting of the receptor to the lysosomal compartment (By similarity). {ECO:0000250}.
uniprot
proteins