Pak3
entrez
29433
canonical
uniprot
Q62829
canonical
ensembl
ENSRNOG00000004676
resolver
ensembl
ENSRNOG00055025067
resolver
ensembl
ENSRNOG00060019042
resolver
ensembl
ENSRNOG00065026400
resolver
ensp
ENSRNOP00000006459
resolver
ensp
ENSRNOP00000075221
resolver
ensp
ENSRNOP00000098250
resolver
ensp
ENSRNOP00000098251
resolver
ensp
ENSRNOP00000098252
resolver
ensp
ENSRNOP00055035354
resolver
ensp
ENSRNOP00060027261
resolver
ensp
ENSRNOP00065037491
resolver
enst
ENSRNOT00000006459
resolver
enst
ENSRNOT00000089141
resolver
enst
ENSRNOT00000120615
resolver
enst
ENSRNOT00000120616
resolver
enst
ENSRNOT00055043349
resolver
enst
ENSRNOT00060033310
resolver
enst
ENSRNOT00065045719
resolver
genesymbol
Pak3
resolver
uniprot
A0A8L2RA18
resolver
uniprot
A0ABK0L4C9
resolver
uniprot
A0ABK0LAU2
resolver
uniprot_entry
A0A8L2RA18_RAT
resolver
uniprot_entry
A0ABK0L4C9_RAT
resolver
uniprot_entry
A0ABK0LAU2_RAT
resolver
uniprot_entry
PAK3_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Activated by binding small G proteins. Binding of GTP-bound CDC42 or RAC1 to the autoregulatory region releases monomers from the autoinhibited dimer, enables phosphorylation of Thr-421 and allows the kinase domain to adopt an active structure (By similarity). {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MSDSLDNEEKPPAPPLRMNSNNRDSSALNHSSKPLPMAPEEKNKKARLRSIFPGGGDKTNKKKEKERPEISLPSDFEHTIHVGFDAVTGEFTGIPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSKETVNNQKYMSFTSGDKSAHGYIAAHQSNTKTASEPPLAPPVSEEEDEEEEEEEDDNEPPPVIAPRPEHTKSIYTRSVVESIASPAAPNKEATPPSAENANSSTLYRNTDRQRKKSKMTDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTALDIATGQEVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPERLSAVFRDFLNRCLEMDVDRRGSAKELLQHPFLKLAKPLSSLTPLILAAKEAIKNSSR
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as a downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development (PubMed:12890786). In hippocampal neurons, necessary for the formation of dendritic spines and excitatory synapses; this function is dependent on kinase activity and may be exerted by the regulation of actomyosin contractility through the phosphorylation of myosin II regulatory light chain (MLC) (By similarity). {ECO:0000250|UniProtKB:Q61036, ECO:0000269|PubMed:12890786}.
uniprot
proteins
mass_dalton
60711
uniprot
proteins
mutagenesis
MUTAGEN 297; /note="K->A: Loss of kinase activity."; /evidence="ECO:0000269|PubMed:12890786"; MUTAGEN 421; /note="T->E: Constitutively active."; /evidence="ECO:0000269|PubMed:12890786
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated when activated by CDC42/p21. {ECO:0000269|PubMed:11278486}.; PTM: Neddylated. {ECO:0000250}.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
protein_family
STE Ser/Thr protein kinase family
uniprot
proteins
protein_family
STE20 subfamily
uniprot
proteins
pubmed
11278486
uniprot
proteins
pubmed
12890786
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
7559638
uniprot
proteins
sequence_length
544
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
uniprot
proteins