Eif2s3y
entrez
100312984
canonical
uniprot
C9WPN6
canonical
ensembl
ENSRNOG00000060048
resolver
ensembl
ENSRNOG00055000827
resolver
ensembl
ENSRNOG00060009659
resolver
ensembl
ENSRNOG00065000177
resolver
ensp
ENSRNOP00000068958
resolver
ensp
ENSRNOP00055001134
resolver
ensp
ENSRNOP00060012726
resolver
ensp
ENSRNOP00065000299
resolver
enst
ENSRNOT00055001405
resolver
enst
ENSRNOT00060016300
resolver
enst
ENSRNOT00065000304
resolver
genesymbol
Eif2s3y
resolver
uniprot
A0A096MIV4
resolver
uniprot
A0A0G2JU42
resolver
uniprot
C9WPN7
resolver
uniprot
W8CEN7
resolver
uniprot_entry
IF2H_RAT
resolver
uniprot_sec
A0A096MIV4
resolver
uniprot_sec
A0A0G2JU42
resolver
uniprot_sec
C9WPN7
resolver
uniprot_sec
W8CEN7
resolver
amino_acid_sequence
MAGGEAGVTLGQPHLSRQDLATLDVTKLTPLSHEIISRQATINIGTIGHVAHGKSTVVKAISGVHTVRFKNELERNITIKLGYANAKIYKLDDSSCPRPECYRSCGSSTPDEFPSDIPGIKGNFRLVRHVSFVDCPGHDILMATMLNGAAVMDAALLLIAGNESCPQPQTSEHLAAIEIMKLKHILILQNKIDLVKESQAKEQYEQILAFVQGTVAEGAPIIPISAQLKYNIEVVCEYIVKKIPVPLRDFTSEPRLIVIRSFDVNKPGCEVDDLKGGVAGGSILKGVLKVGQEIEVRPGIVSKDSEGKLMCKPIFSKIVSLFAEHNDLQYAAPGGLIGVGTKIDPTLCRADRMVGQVLGAVGALPEIFTELEISYFLLRRLLGVRTEGDKKAAKVQKLSKNEVLMVNIGSLSTGGRVSAVKADLGKIVLTNPVCTEVGEKIALSRRVEKHWRLIGWGQIRRGVTIKPTIDDE
uniprot
proteins
ec_number
3.6.5.3
uniprot
proteins
function
FUNCTION: Member of the eIF2 complex that functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form the 43S pre-initiation complex (43S PIC). Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). Along with its paralog on chromosome X, may contribute to spermatogenesis up to the round spermatid stage (By similarity). {ECO:0000250|UniProtKB:P05198, ECO:0000250|UniProtKB:Q9Z0N1}.
uniprot
proteins
mass_dalton
51154
uniprot
proteins
protein_family
Classic translation factor GTPase family
uniprot
proteins
protein_family
EIF2G subfamily
uniprot
proteins
protein_family
TRAFAC class translation factor GTPase superfamily
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
20333173
uniprot
proteins
pubmed
24759410
uniprot
proteins
pubmed
25548914
uniprot
proteins
pubmed
9736774
uniprot
proteins
sequence_length
472
uniprot
proteins