IL18RAP
entrez
8807
canonical
uniprot
O95256
canonical
ensembl
ENSG00000115607
resolver
ensp
ENSP00000264260
resolver
ensp
ENSP00000387201
resolver
ensp
ENSP00000510345
resolver
ensp
ENSP00000533614
resolver
genesymbol
IL18RAP
resolver
genesymbol_syn
IL1R7
resolver
hgnc
HGNC:5989
resolver
uniprot
B2RPJ3
resolver
uniprot
Q2QDE5
resolver
uniprot
Q3KPE7
resolver
uniprot
Q3KPE8
resolver
uniprot
Q53TT4
resolver
uniprot
Q53TU5
resolver
uniprot_entry
I18RA_HUMAN
resolver
uniprot_sec
B2RPJ3
resolver
uniprot_sec
Q2QDE5
resolver
uniprot_sec
Q3KPE7
resolver
uniprot_sec
Q3KPE8
resolver
uniprot_sec
Q53TT4
resolver
uniprot_sec
Q53TU5
resolver
amino_acid_sequence
MLCLGWIFLWLVAGERIKGFNISGCSTKKLLWTYSTRSEEEFVLFCDLPEPQKSHFCHRNRLSPKQVPEHLPFMGSNDLSDVQWYQQPSNGDPLEDIRKSYPHIIQDKCTLHFLTPGVNNSGSYICRPKMIKSPYDVACCVKMILEVKPQTNASCEYSASHKQDLLLGSTGSISCPSLSCQSDAQSPAVTWYKNGKLLSVERSNRIVVDEVYDYHQGTYVCDYTQSDTVSSWTVRAVVQVRTIVGDTKLKPDILDPVEDTLEVELGKPLTISCKARFGFERVFNPVIKWYIKDSDLEWEVSVPEAKSIKSTLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQLKEKRGVVLLYILLGTIGTLVAVLAASALLYRHWIEIVLLYRTYQSKDQTLGDKKDFDAFVSYAKWSSFPSEATSSLSEEHLALSLFPDVLENKYGYSLCLLERDVAPGGVYAEDIVSIIKRSRRGIFILSPNYVNGPSIFELQAAVNLALDDQTLKLILIKFCYFQEPESLPHLVKKALRVLPTVTWRGLKSVPPNSRFWAKMRYHMPVKNSQGFTWNQLRITSRIFQWKGLSRTETTGRSSQPKEW
uniprot
proteins
ec_number
3.2.2.6
uniprot
proteins
function
FUNCTION: Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation (PubMed:14528293, PubMed:25500532, PubMed:9792649). May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable). {ECO:0000269|PubMed:14528293, ECO:0000269|PubMed:25500532, ECO:0000269|PubMed:9792649, ECO:0000305|PubMed:10653850}.
uniprot
proteins
mass_dalton
68310
uniprot
proteins
mutagenesis
MUTAGEN 15..176; /note="Missing: Impairs IL18 receptor signaling via NF-kappa-B."; /evidence="ECO:0000269|PubMed:25500532"; MUTAGEN 167; /note="L->A: Decreases binding to the preformed binary complex of IL18 and IL18R1."; /evidence="ECO:0000269|PubMed:25500532"; MUTAGEN 210; /note="E->A: Decreases binding to the preformed binary complex of IL18 and IL18R1. Impairs IL18 receptor signaling via NF-kappa-B; when associated with A-212 and A-214."; /evidence="ECO:0000269|PubMed:25500532"; MUTAGEN 212; /note="Y->A: Abolishes binding to the preformed binary complex of IL18 and IL18R1. Impairs IL18 receptor signaling via NF-kappa-B; when associated with A-210 and A-214."; /evidence="ECO:0000269|PubMed:25500532"; MUTAGEN 214; /note="Y->A: Decreases binding to the preformed binary complex of IL18 and IL18R1. Impairs IL18 receptor signaling via NF-kappa-B; when associated with A-210 and A-212."; /evidence="ECO:0000269|PubMed:25500532"; MUTAGEN 313; /note="K->A: Decreases binding to the preformed binary complex of IL18 and IL18R1. Decreases IL18 receptor signaling via NF-kappa-B."; /evidence="ECO:0000269|PubMed:25500532
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:25500532}.
uniprot
proteins
protein_family
Interleukin-1 receptor family
uniprot
proteins
pubmed
10653850
uniprot
proteins
pubmed
10925275
uniprot
proteins
pubmed
11046021
uniprot
proteins
pubmed
14528293
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
17897836
uniprot
proteins
pubmed
25500532
uniprot
proteins
pubmed
9792649
uniprot
proteins
sequence_length
599
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14528293}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 357..377; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins