Pclaf
entrez
300795
canonical
uniprot
Q6RIA2
canonical
ensembl
ENSRNOG00000067723
resolver
ensembl
ENSRNOG00055025156
resolver
ensembl
ENSRNOG00060017450
resolver
ensembl
ENSRNOG00065006530
resolver
ensp
ENSRNOP00000091479
resolver
ensp
ENSRNOP00055035355
resolver
ensp
ENSRNOP00060024037
resolver
ensp
ENSRNOP00065007348
resolver
enst
ENSRNOT00000112544
resolver
enst
ENSRNOT00055043351
resolver
enst
ENSRNOT00060029825
resolver
enst
ENSRNOT00065010075
resolver
genesymbol
Pclaf
resolver
genesymbol_syn
Ns5atp9
resolver
genesymbol_syn
Paf
resolver
uniprot_entry
PAF15_RAT
resolver
amino_acid_sequence
MVRTKANYVPGAYRKVVASQAPRKVLGSSTFVTNSSGSSRKAENKYAGGNPVCVRPTPKWQKGIGEFFRLSPKDSKKENQIPEEAGSSGLGKAKRKACPLQPDHRDDENE
uniprot
proteins
function
FUNCTION: PCNA-binding protein that acts as a regulator of DNA repair during DNA replication. Following DNA damage, the interaction with PCNA is disrupted, facilitating the interaction between monoubiquitinated PCNA and the translesion DNA synthesis DNA polymerase eta (POLH) at stalled replisomes, facilitating the bypass of replication-fork-blocking lesions. Also acts as a regulator of centrosome number (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
12006
uniprot
proteins
post_translational_modification
PTM: Monoubiquitinated at Lys-15 and Lys-24 during normal S phase, promoting its association with PCNA. Also diubiquitinated at these 2 sites. Following DNA damage, monoubiquitin chains at Lys-15 and Lys-24 are probably extended, leading to disrupt the interaction with PCNA. Polyubiquitinated by the APC/C complex at the mitotic exit, leading to its degradation by the proteasome (By similarity). {ECO:0000250}.
uniprot
proteins
sequence_length
110
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q15004}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q15004}. Note=Following DNA damage, localizes to DNA damage sites. Colocalizes with centrosomes in perinuclear region. {ECO:0000250|UniProtKB:Q15004}.
uniprot
proteins