Cnot9
entrez
58184
canonical
uniprot
Q9JKY0
canonical
ensembl
ENSMUSG00000026174
resolver
ensp
ENSMUSP00000084466
resolver
enst
ENSMUST00000087215
resolver
genesymbol
Cnot9
resolver
genesymbol_syn
Rcd1
resolver
genesymbol_syn
Rqcd1
resolver
uniprot_entry
CNOT9_MOUSE
resolver
amino_acid_sequence
MHSLATAAPVPTALAQVDREKIYQWINELSSPETRENALLELSKKRESVPDLAPMLWHSFGTIAALLQEIVNIYPSINPPTLTAHQSNRVCNALALLQCVASHPETRSAFLAAHIPLFLYPFLHTVSKTRPFEYLRLTSLGVIGALVKTDEQEVINFLLTTEIIPLCLRIMESGSELSKTVATFILQKILLDDTGLAYICQTYERFSHVAMILGKMVLQLSKEPSARLLKHVVRCYLRLSDNPRAREALRQCLPDQLKDTTFAQVLKDDTTTKRWLAQLVKNLQEGQVTDPRGIPLPPQ
uniprot
proteins
function
FUNCTION: Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation. Required for retinoic acid-induced differentiation of F9 teratocarcinoma cells. Does not bind DNA by itself. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors. May play a role in cell differentiation. {ECO:0000269|PubMed:12356739, ECO:0000269|PubMed:15209511}.
uniprot
proteins
mass_dalton
33601
uniprot
proteins
protein_family
CNOT9 family
uniprot
proteins
pubmed
10880228
uniprot
proteins
pubmed
12356739
uniprot
proteins
pubmed
15209511
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20133598
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
299
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15209511}. Cytoplasm, P-body {ECO:0000269|PubMed:20133598}. Note=NANOS2 promotes its localization to P-body. {ECO:0000269|PubMed:20133598}.
uniprot
proteins