Mgst1
entrez
171341
canonical
uniprot
P08011
canonical
ensembl
ENSRNOG00000007743
resolver
ensembl
ENSRNOG00055026264
resolver
ensembl
ENSRNOG00060009437
resolver
ensembl
ENSRNOG00065011937
resolver
ensp
ENSRNOP00000010579
resolver
ensp
ENSRNOP00055037183
resolver
ensp
ENSRNOP00060012482
resolver
ensp
ENSRNOP00065014845
resolver
enst
ENSRNOT00000010579
resolver
enst
ENSRNOT00055045380
resolver
enst
ENSRNOT00060015966
resolver
enst
ENSRNOT00065019403
resolver
genesymbol
Mgst1
resolver
genesymbol_syn
Gst12
resolver
uniprot
B6DYQ4
resolver
uniprot_entry
B6DYQ4_RAT
resolver
uniprot_entry
MGST1_RAT
resolver
activity_regulation
ACTIVITY REGULATION: In vitro, can be activated by reagents that attack Cys-50 sulfhydryl, such as N-ethylmaleimide and via nitration of Tyr-93 by peroxynitrite. {ECO:0000269|PubMed:11106493, ECO:0000269|PubMed:16314419}.
uniprot
proteins
amino_acid_sequence
MADLKQLMDNEVLMAFTSYATIILAKMMFLSSATAFQRLTNKVFANPEDCAGFGKGENAKKFLRTDEKVERVRRAHLNDLENIVPFLGIGLLYSLSGPDLSTALIHFRIFVGARIYHTIAYLTPLPQPNRGLAFFVGYGVTLSMAYRLLRSRLYL
uniprot
proteins
ec_number
2.5.1.18
uniprot
proteins
function
FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. {ECO:0000269|PubMed:11106493, ECO:0000269|PubMed:16314419}.
uniprot
proteins
mass_dalton
17472
uniprot
proteins
mutagenesis
MUTAGEN 76; /note="H->Q: Decreased enzyme activity."; /evidence="ECO:0000269|PubMed:16806268"; MUTAGEN 81; /note="E->Q: Loss of enzyme activity."; /evidence="ECO:0000269|PubMed:16806268
uniprot
proteins
post_translational_modification
PTM: In vitro, peroxynitrite induces nitration at Tyr-93 which activates the enzyme. {ECO:0000269|PubMed:16314419}.
uniprot
proteins
protein_family
MAPEG family
uniprot
proteins
pubmed
11106493
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16314419
uniprot
proteins
pubmed
16806268
uniprot
proteins
pubmed
3372534
uniprot
proteins
pubmed
3932348
uniprot
proteins
pubmed
6439207
uniprot
proteins
sequence_length
155
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:6439207}; Multi-pass membrane protein {ECO:0000255}. Mitochondrion outer membrane {ECO:0000269|PubMed:6439207}.
uniprot
proteins
transmembrane_region
TRANSMEM 10..33; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 63..96; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 100..123; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 129..148; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins