Mia3
entrez
338366
canonical
uniprot
Q8BI84
canonical
ensembl
ENSMUSG00000056050
resolver
ensp
ENSMUSP00000141268
resolver
ensp
ENSMUSP00000288721
resolver
ensp
ENSMUSP00000288722
resolver
ensp
ENSMUSP00000288726
resolver
enst
ENSMUST00000194543
resolver
genesymbol
Mia3
resolver
genesymbol_syn
Kiaa0268
resolver
genesymbol_syn
Tango
resolver
uniprot
A0A0R4J2D3
resolver
uniprot
A0JLX8
resolver
uniprot
Q3UFI9
resolver
uniprot
Q571D7
resolver
uniprot
Q8BJE9
resolver
uniprot
Q8BL31
resolver
uniprot
Q8C5B9
resolver
uniprot_entry
A0A0R4J2D3_MOUSE
resolver
uniprot_entry
TGO1_MOUSE
resolver
uniprot_sec
A0JLX8
resolver
uniprot_sec
Q3UFI9
resolver
uniprot_sec
Q571D7
resolver
uniprot_sec
Q8BJE9
resolver
uniprot_sec
Q8BL31
resolver
uniprot_sec
Q8C5B9
resolver
amino_acid_sequence
MAAAPGLLFWLFVLGALWWVPGQSDLSHGRRFSDLKVCGDEECSMLMYRGKALEDFTGPDCRFVNFKKGDDVYVYYKLAGGSLELWAGSVEHSFGYFPKDLIKVLHKYTEEELHIPADETDFVCFEGGRDDFNSYNVEELLGSLELEDSVPEESKKAEEVSQHREKSPEESRGRELDPVPEPEAFRADSEDGEGAFSESTEGLQGQPSAQESHPHTSGPAANAQGVQSSLDTFEEILHDKLKVPGSESRTGNSSPASVEREKTDAYKVLKTEMSLDLKTKFGSTADALVSDDEATRLVTSLEDGFDEALDAEYYPMEEEEEVEEDADSSDELPLLTFSDKDEKVPGKPMIEKYLTDKDPNLSEEDKVEPPTWGDAFFSIVTGGEGKPGVVDLERSIEEEEDVSVSSSHQRKPQPAAGYTDSEDEGDDLFVEEPKTNDVKDSETDPELVITGEEKDIQESRKGLVQPESQSEDAKSETASAYRLQGSKLNPLSAAEKGRDFTLKAVFEKKENGLKESVIHISKETLHEDKTREIQRDSLESELVHRALGSSVTENNKPKSLGVAPLLGNNKPDASKDSTEVPDGSVSGPKAGQQEGFLEPGLKTQHQPRFSPPEETGPSRELGGKVPISGRNLSWQQEQDVAAVVGKHANEKTGFPEEESREDGTDAEQARAIRRPQEAESPEVLSVQPGRPDEEEEEEEGDNYPPEGLMEDENAVSAQQSRENSPSARDGRSDMNSQVFEKVILGTLNLNTEKTKQPANMILETGQESETTSEEAGDVGKESGHSVVVDSEESHLADMRAQRPSQVHGLRDETAAQTPGSGEAVLSKNPNDLQKDNPEEELVNTLGLEDPGVGEISEGEPEDTKEFGVSESQGTDAEDLRDDPSRQATPEIPDIVLKSIREDLPIINSFFKDDQQSLHRFLKYFDVRELEGLLEDMSIRLRSAHQNSLPYNMEKVLDKVFRASESRILSMAEKMLDTGVAKNRDLGSKESSPLEEAEVLDDIQDLIYFVRYQYSGVETAPLVTPPPPEEGWARPGEERQPPQQDSLPQENTGDLSVQPPEEPELSDQPVTSVQPPEEPELSDQPVTSVQPPEEPELSDQPVTSVQPPEEPELSDQPVTGYTSTSEVSQKPDTKKDIDLGPVMEGGPVGAGDVQKQLETIAEEPAAVPPLESAFGSLYAFILYLSKMLLATLPDNVQPGPDFYGLPWQPVIITAVLGIVSFAIFSWRTILVVKSRVYQVTEKQISEKLENIKKENAELMQKLSSYEQKIKESKKYVQETKKQNMILSDEAVKYKDKIKILEETNVSLGDKAKSLRLQLESEREQNVKNQDLILENKKSIEKLKDVISMNASELSEVQVALNEAKLSEENVKSECHRVQEENARLKKKKEQLQQQVEEWSKSHAELTGQIKSFEKSQEDLEIALTHKDDNISALTNCITQLNRLECELESEDPDKGGNESDDLANGETGGDRSEKIRNRIKQMMDVSRTQTAVSIVEEDLKLLQLKLRASMSTKCNLEDQIKKLEDDRSSLQTAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQDREQRLTAADEKVVLAAEEVKTYKRRIEEMEEELQKTERSFKNQIAAHEKKAHDNWLKARAAERAMAEEKREAANLRHKLLEMTQKMAMRQDEPVIVKPMPGRPNTQNPPRRGLLSQNGSFGPSPVSGGECSPPLPAEPPGRPLSATLSRRDTPRSEFGSLDRHLPRPRWPSEASGKHSASDPGPAPVVNSSSRSSSPAKAVDEGKVNMAPKGPPPFPGVPLMGGPVPPPIRYGPPPQLCGGPFGPRPLPPPFVPGMHPPLGVREYAPGVLPGKRDLPLDPREFLPGHTPFRPPGSLGPREFFIPGTRLPPPTHGPQEYPPPPPAVRDSLPSGPREEAKPASPSSVQDRSQASKPTP
uniprot
proteins
function
FUNCTION: Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers. It may participate in cargo loading of COL7A1 at endoplasmic reticulum exit sites by binding to COPII coat subunits Sec23/24 and guiding SH3-bound COL7A1 into a growing carrier. Does not play a role in global protein secretion and is apparently specific to COL7A1 cargo loading. However, it may participate in secretion of other proteins in cells that do not secrete COL7A1. It is also specifically required for the secretion of lipoproteins by participating in their export from the endoplasmic reticulum. Required for correct assembly of COPII coat components at endoplasmic reticulum exit sites (ERES) and for the localization of SEC16A and membrane-bound ER-resident complexes consisting of MIA2 and PREB/SEC12 to ERES. {ECO:0000250|UniProtKB:Q5JRA6}.
uniprot
proteins
mass_dalton
213675
uniprot
proteins
protein_family
MIA/OTOR family
uniprot
proteins
protein_family
Tango1 subfamily
uniprot
proteins
pubmed
15183315
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19131326
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
1930
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q5JRA6}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q5JRA6}. Note=Localizes at endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). SEC16A is required for its proper localization to ERES. After loading of COL7A1 into transport carriers, it is not incorporated into COPII carriers and remains in the endoplasmic reticulum membrane. {ECO:0000250|UniProtKB:Q5JRA6}.
uniprot
proteins
transmembrane_region
TRANSMEM 1203..1223; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins