THEM4
entrez
117145
canonical
uniprot
Q5T1C6
canonical
ensembl
ENSG00000159445
resolver
ensp
ENSP00000357804
resolver
enst
ENST00000368814
resolver
genesymbol
THEM4
resolver
genesymbol_syn
CTMP
resolver
hgnc
HGNC:17947
resolver
uniprot
A8K0C9
resolver
uniprot
B2RBX2
resolver
uniprot
Q96KR2
resolver
uniprot_entry
A8K0C9_HUMAN
resolver
uniprot_entry
THEM4_HUMAN
resolver
uniprot_sec
B2RBX2
resolver
uniprot_sec
Q96KR2
resolver
amino_acid_sequence
MLRSCAARLRTLGALCLPPVGRRLPGSEPRPELRSFSSEEVILKDCSVPNPSWNKDLRLLFDQFMKKCEDGSWKRLPSYKRTPTEWIQDFKTHFLDPKLMKEEQMSQAQLFTRSFDDGLGFEYVMFYNDIEKRMVCLFQGGPYLEGPPGFIHGGAIATMIDATVGMCAMMAGGIVMTANLNINYKRPIPLCSVVMINSQLDKVEGRKFFVSCNVQSVDEKTLYSEATSLFIKLNPAKSLT
uniprot
proteins
ec_number
3.1.2.2
uniprot
proteins
function
FUNCTION: Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays a role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane. {ECO:0000269|PubMed:11598301, ECO:0000269|PubMed:17615157, ECO:0000269|PubMed:19168129, ECO:0000269|PubMed:19421406, ECO:0000269|PubMed:19453107, ECO:0000269|PubMed:22871024}.
uniprot
proteins
mass_dalton
27130
uniprot
proteins
mutagenesis
MUTAGEN 37..38; /note="SS->DD: Abolishes import into the mitochondria."; /evidence="ECO:0000269|PubMed:19604401"; MUTAGEN 37; /note="S->A: Abolishes cleavage of mitochondrial transit peptide."; /evidence="ECO:0000269|PubMed:19168129"; MUTAGEN 152; /note="H->A,F: Strongly reduced enzyme activity."; /evidence="ECO:0000269|PubMed:22871024"; MUTAGEN 161; /note="D->E,N: Nearly abolishes enzyme activity. Strongly reduced affinity for myristoyl-CoA."; /evidence="ECO:0000269|PubMed:22871024"; MUTAGEN 177; /note="T->A: Strongly reduced enzyme activity."; /evidence="ECO:0000269|PubMed:22871024"; MUTAGEN 183; /note="N->A: No effect on enzyme activity."; /evidence="ECO:0000269|PubMed:22871024"; MUTAGEN 206; /note="R->A: Reduces enzyme activity."; /evidence="ECO:0000269|PubMed:22871024"; MUTAGEN 207; /note="K->A: Slightly reduced enzyme activity."; /evidence="ECO:0000269|PubMed:22871024
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. {ECO:0000269|PubMed:11598301, ECO:0000269|PubMed:19604401}.
uniprot
proteins
protein_family
THEM4/THEM5 thioesterase family
uniprot
proteins
pubmed
11598301
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15026474
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17013611
uniprot
proteins
pubmed
17615157
uniprot
proteins
pubmed
19168129
uniprot
proteins
pubmed
19421406
uniprot
proteins
pubmed
19453107
uniprot
proteins
pubmed
19604401
uniprot
proteins
pubmed
22586271
uniprot
proteins
pubmed
22871024
uniprot
proteins
sequence_length
240
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11598301}. Cell projection, ruffle membrane {ECO:0000269|PubMed:11598301}. Cytoplasm {ECO:0000269|PubMed:19604401}. Mitochondrion {ECO:0000269|PubMed:19168129, ECO:0000269|PubMed:19421406, ECO:0000269|PubMed:19604401}. Mitochondrion inner membrane; Peripheral membrane protein {ECO:0000269|PubMed:19168129}. Mitochondrion intermembrane space {ECO:0000269|PubMed:19168129, ECO:0000269|PubMed:19604401}. Note=Released from the mitochondria into the cytosol in response to apoptotic stimuli. {ECO:0000269|PubMed:19168129}.
uniprot
proteins