Ing2
entrez
69260
canonical
uniprot
Q9ESK4
canonical
ensembl
ENSMUSG00000063049
resolver
ensp
ENSMUSP00000079226
resolver
enst
ENSMUST00000080353
resolver
genesymbol
Ing2
resolver
genesymbol_syn
Ing1l
resolver
genesymbol_syn
Ing2b
resolver
uniprot
B6ZI39
resolver
uniprot
Q4VAD7
resolver
uniprot
Q80VI5
resolver
uniprot
Q8BGU8
resolver
uniprot_entry
B6ZI39_MOUSE
resolver
uniprot_entry
ING2_MOUSE
resolver
uniprot_sec
Q4VAD7
resolver
uniprot_sec
Q80VI5
resolver
uniprot_sec
Q8BGU8
resolver
amino_acid_sequence
MLGQQQQQQLYSSAALLTGERSRLLSCYVQDYLECVESLPHDMQRNVSVLRELDNKYQETLKEIDDVYEKYKKEDDSNQKKRLQQHLQRALINSQELGDEKIQIVTQMLELVENRARQMELHSQCFQDPAESERASDKSKMDSSQPERSSRRPRRQRTSESRDLCHMTNGIDDCDDQPPKEKRSKSAKKKKRSKAKQEREASPVEFAIDPNEPTYCLCNQVSYGEMIGCDNEQCPIEWFHFSCVSLTYKPKGKWYCPKCRGDNEKTMDKSTEKTKKERRAR
uniprot
proteins
function
FUNCTION: Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs) (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
32978
uniprot
proteins
post_translational_modification
PTM: Sumoylation enhances its association with SIN3A and is required for binding to some target gene promoters, this is the case for TMEM71. {ECO:0000250}.
uniprot
proteins
protein_family
ING family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
sequence_length
281
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm (By similarity). {ECO:0000250}.
uniprot
proteins