SEMA6D
entrez
80031
canonical
uniprot
Q8NFY4
canonical
ensembl
ENSG00000137872
resolver
ensp
ENSP00000324857
resolver
ensp
ENSP00000346786
resolver
ensp
ENSP00000348276
resolver
ensp
ENSP00000350770
resolver
ensp
ENSP00000374076
resolver
ensp
ENSP00000374079
resolver
ensp
ENSP00000446152
resolver
ensp
ENSP00000452815
resolver
ensp
ENSP00000534733
resolver
genesymbol
SEMA6D
resolver
genesymbol_syn
KIAA1479
resolver
hgnc
HGNC:16770
resolver
uniprot
A6NF10
resolver
uniprot
A6NM95
resolver
uniprot
A6NNK1
resolver
uniprot
A7E2A0
resolver
uniprot
Q8NFY3
resolver
uniprot
Q8NFY5
resolver
uniprot
Q8NFY6
resolver
uniprot
Q8NFY7
resolver
uniprot
Q9P249
resolver
uniprot_entry
SEM6D_HUMAN
resolver
uniprot_sec
A6NF10
resolver
uniprot_sec
A6NM95
resolver
uniprot_sec
A6NNK1
resolver
uniprot_sec
A7E2A0
resolver
uniprot_sec
Q8NFY3
resolver
uniprot_sec
Q8NFY5
resolver
uniprot_sec
Q8NFY6
resolver
uniprot_sec
Q8NFY7
resolver
uniprot_sec
Q9P249
resolver
amino_acid_sequence
MRVFLLCAYILLLMVSQLRAVSFPEDDEPLNTVDYHYSRQYPVFRGRPSGNESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNEMPKTEVIPNKKLTWRSRQQDRENCAMKGKHKDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLSTLEYDGEEISGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWIKEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTSFLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMDDIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDETLSFIKSHPLMDSAVPPIADEPWFTKTRVRYRLTAISVDHSAGPYQNYTVIFVGSEAGMVLKVLAKTSPFSLNDSVLLEEIEAYNHAKCSAENEEDKKVISLQLDKDHHALYVAFSSCIIRIPLSRCERYGSCKKSCIASRDPYCGWLSQGSCGRVTPGMLAEGYEQDTEFGNTAHLGDCHEILPTSTTPDYKIFGGPTSDMEVSSSSVTTMASIPEITPKVIDTWRPKLTSSRKFVVQDDPNTSDFTDPLSGIPKGVRWEVQSGESNQMVHMNVLITCVFAAFVLGAFIAGVAVYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSNLLTSRKELPPNGDTKSMVMDHRGQPPELAALPTPESTPVLHQKTLQAMKSHSEKAHGHGASRKETPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFSNSNAHKAEKKLQNIDHPLTKSSSKRDHRRSVDSRNTLNDLLKHLNDPNSNPKAIMGDIQMAHQNLMLDPMGSMSEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQRGYHKNSSQRHSISAMPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQPSLSRQSSYTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTPSVRPLNKYTY
uniprot
proteins
function
FUNCTION: Shows growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro. May be a stop signal for the DRG neurons in their target areas, and possibly also for other neurons. May also be involved in the maintenance and remodeling of neuronal connections. Ligand of TREM2 with PLXNA1 as coreceptor in dendritic cells, plays a role in the generation of immune responses and skeletal homeostasis (By similarity). {ECO:0000250|UniProtKB:Q76KF0}.
uniprot
proteins
mass_dalton
119872
uniprot
proteins
protein_family
Semaphorin family
uniprot
proteins
pubmed
10819331
uniprot
proteins
pubmed
12110693
uniprot
proteins
pubmed
12168954
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
23186163
uniprot
proteins
sequence_length
1073
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 4]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 5]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform 7]: Cytoplasm.
uniprot
proteins
transmembrane_region
TRANSMEM 663..683; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins