Cripto
entrez
21667
canonical
uniprot
P51865
canonical
ensembl
ENSMUSG00000032494
resolver
ensp
ENSMUSP00000035075
resolver
enst
ENSMUST00000035075
resolver
genesymbol
Cripto
resolver
genesymbol_syn
Tdgf1
resolver
uniprot
Q3UZP8
resolver
uniprot
Q7TQ06
resolver
uniprot_entry
Q3UZP8_MOUSE
resolver
uniprot_entry
TDGF1_MOUSE
resolver
uniprot_sec
Q7TQ06
resolver
amino_acid_sequence
MGYFSSSVVLLVAISSAFEFGPVAGRDLAIRDNSIWDQKEPAVRDRSFQFVPSVGIQNSKSLNKTCCLNGGTCILGSFCACPPSFYGRNCEHDVRKEHCGSILHGTWLPKKCSLCRCWHGQLHCLPQTFLPGCDGHVMDQDLKASGTPCQTPSVTTTFMLAGACLFLDMKV
uniprot
proteins
function
FUNCTION: GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated CRIPTO acts as a Nodal coreceptor in cis. Shedding of CRIPTO by Tmem8a modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells. Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm. {ECO:0000250|UniProtKB:P13385}.
uniprot
proteins
mass_dalton
18655
uniprot
proteins
mutagenesis
MUTAGEN 107; /note="W->A: Unable to bind Cripto receptor."; /evidence="ECO:0000269|PubMed:17125258
uniprot
proteins
post_translational_modification
PTM: The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, it is processed by GPI processing phospholipase A2 (Tmem8a), removing an acyl-chain at the sn-2 position of GPI and releasing CRIPTO as a lysophosphatidylinositol-bearing form, which is further cleaved by phospholipase D (Gpld1) into a soluble form. {ECO:0000250|UniProtKB:P13385}.
uniprot
proteins
protein_family
EGF-CFC (Cripto-1/FRL1/Cryptic) family
uniprot
proteins
pubmed
10640699
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17125258
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
7916676
uniprot
proteins
pubmed
8661720
uniprot
proteins
sequence_length
171
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:10640699}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:10640699}. Secreted {ECO:0000250|UniProtKB:P13385}. Note=Released from the cell membrane by GPI cleavage. {ECO:0000250|UniProtKB:P13385}.
uniprot
proteins