TAS2R46
entrez
259292
canonical
uniprot
P59540
canonical
ensembl
ENSG00000226761
resolver
ensembl
ENSG00000262525
resolver
ensembl
ENSG00000278111
resolver
ensp
ENSP00000436450
resolver
ensp
ENSP00000460229
resolver
ensp
ENSP00000488678
resolver
enst
ENST00000533467
resolver
enst
ENST00000574263
resolver
enst
ENST00000633803
resolver
genesymbol
TAS2R46
resolver
hgnc
HGNC:18877
resolver
uniprot
A0A0J9YY42
resolver
uniprot
P59548
resolver
uniprot
Q645X6
resolver
uniprot_entry
A0A0J9YY42_HUMAN
resolver
uniprot_entry
T2R46_HUMAN
resolver
uniprot_sec
P59548
resolver
uniprot_sec
Q645X6
resolver
amino_acid_sequence
MITFLPIIFSILIVVTFVIGNFANGFIALVNSIEWFKRQKISFADQILTALAVSRVGLLWVLVLNWYATELNPAFNSIEVRITAYNVWAVINHFSNWLATSLSIFYLLKIANFSNLIFLHLKRRVKSVVLVILLGPLLFLVCHLFVINMNQIIWTKEYEGNMTWKIKLRSAMYLSNTTVTILANLVPFTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSMKVHIKALQTVTSFLLLCAIYFLSIIMSVWSFESLENKPVFMFCEAIAFSYPSTHPFILIWGNKKLKQTFLSVLWHVRYWVKGEKPSSS
uniprot
proteins
function
FUNCTION: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
35523
uniprot
proteins
protein_family
G protein-coupled receptor T2R family
uniprot
proteins
pubmed
11696554
uniprot
proteins
pubmed
12139982
uniprot
proteins
pubmed
12379855
uniprot
proteins
pubmed
12581520
uniprot
proteins
pubmed
12584440
uniprot
proteins
pubmed
15496549
uniprot
proteins
pubmed
19628819
uniprot
proteins
sequence_length
309
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:19628819}; Multi-pass membrane protein {ECO:0000269|PubMed:19628819}. Cell projection, cilium membrane {ECO:0000269|PubMed:19628819}. Note=In airway epithelial cells, localizes to motile cilia.
uniprot
proteins
transmembrane_region
TRANSMEM 2..22; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 47..67; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 87..107; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 127..147; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 179..199; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 230..250; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 260..280; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins