Clic2
entrez
294141
canonical
uniprot
Q5M883
canonical
ensembl
ENSRNOG00000000728
resolver
ensembl
ENSRNOG00055007032
resolver
ensembl
ENSRNOG00060003007
resolver
ensembl
ENSRNOG00065032980
resolver
ensp
ENSRNOP00000000955
resolver
ensp
ENSRNOP00055009149
resolver
ensp
ENSRNOP00060003588
resolver
ensp
ENSRNOP00065046729
resolver
enst
ENSRNOT00000000955
resolver
enst
ENSRNOT00055011616
resolver
enst
ENSRNOT00060004927
resolver
enst
ENSRNOT00065056750
resolver
genesymbol
Clic2
resolver
uniprot_entry
CLIC2_RAT
resolver
amino_acid_sequence
MASLALNTQADPEIELFVKAGSDGESIGNCPFCQRLFMILWLKGVKFNVTTIDTARKPEELKDLAPGTNPPFLIYNKELKTDFIKIEEFLEKTLAPPRYPHLSPKYKESFDVGCNLFAKFSAYIKNTQKEANKNFEKSLLREFKRLDDYLNTPLLDEIDPDSTEERTLSRRLFLDGDQLTLADCSLLPKLNIIKVAAKKYRDFDIPAEFSGVWRYLHNAYAREEFAHTCPEDKEIENTYASVAKQ
uniprot
proteins
ec_number
1.11.1.-
uniprot
proteins
ec_number
1.8.-.-
uniprot
proteins
function
FUNCTION: In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Displays weak glutathione peroxidase activity (By similarity). Can insert into membranes and form chloride ion channels. Membrane insertion seems to be redox-regulated and may occur only under oxidizing conditions. Modulates the activity of RYR2 and inhibits calcium influx (By similarity). {ECO:0000250|UniProtKB:O15247}.
uniprot
proteins
mass_dalton
28161
uniprot
proteins
protein_family
Chloride channel CLIC family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
245
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 32..52; /note="Helical; Note=After insertion into the membrane"; /evidence="ECO:0000255
uniprot
proteins