CD9
entrez
928
canonical
uniprot
P21926
canonical
ensembl
ENSG00000010278
resolver
ensp
ENSP00000009180
resolver
ensp
ENSP00000371955
resolver
ensp
ENSP00000371958
resolver
ensp
ENSP00000371959
resolver
ensp
ENSP00000478288
resolver
ensp
ENSP00000494858
resolver
ensp
ENSP00000495090
resolver
ensp
ENSP00000496639
resolver
ensp
ENSP00000502917
resolver
ensp
ENSP00000564398
resolver
ensp
ENSP00000564400
resolver
ensp
ENSP00000595043
resolver
ensp
ENSP00000617466
resolver
ensp
ENSP00000680206
resolver
enst
ENST00000009180
resolver
enst
ENST00000382515
resolver
enst
ENST00000382518
resolver
enst
ENST00000382519
resolver
enst
ENST00000538834
resolver
enst
ENST00000610354
resolver
enst
ENST00000642746
resolver
enst
ENST00000646407
resolver
enst
ENST00000676764
resolver
enst
ENST00000894339
resolver
enst
ENST00000947407
resolver
genesymbol
CD9
resolver
genesymbol_syn
MIC3
resolver
genesymbol_syn
TSPAN29
resolver
hgnc
HGNC:1709
resolver
uniprot
A0A087WU13
resolver
uniprot
A6NNI4
resolver
uniprot
B4DK09
resolver
uniprot
D3DUQ9
resolver
uniprot
G8JLH6
resolver
uniprot
Q5J7W6
resolver
uniprot
Q96ES4
resolver
uniprot_entry
A0A087WU13_HUMAN
resolver
uniprot_entry
A6NNI4_HUMAN
resolver
uniprot_entry
B4DK09_HUMAN
resolver
uniprot_entry
CD9_HUMAN
resolver
uniprot_entry
G8JLH6_HUMAN
resolver
uniprot_sec
D3DUQ9
resolver
uniprot_sec
Q5J7W6
resolver
uniprot_sec
Q96ES4
resolver
amino_acid_sequence
MPVKGGTKCIKYLLFGFNFIFWLAGIAVLAIGLWLRFDSQTKSIFEQETNNNNSSFYTGVYILIGAGALMMLVGFLGCCGAVQESQCMLGLFFGFLLVIFAIEIAAAIWGYSHKDEVIKEVQEFYKDTYNKLKTKDEPQRETLKAIHYALNCCGLAGGVEQFISDICPKKDVLETFTVKSCPDAIKEVFDNKFHIIGAVGIGIAVVMIFGMIFSMILCCAIRRNREMV
uniprot
proteins
function
FUNCTION: Integral membrane protein associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion (PubMed:14575715, PubMed:18541721, PubMed:8478605). Present at the cell surface of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents macrophage fusion into multinucleated giant cells specialized in ingesting complement-opsonized large particles (PubMed:12796480). Also prevents the fusion between mononuclear cell progenitors into osteoclasts in charge of bone resorption (By similarity). Acts as a receptor for PSG17 (By similarity). Involved in platelet activation and aggregation (PubMed:18541721). Regulates paranodal junction formation (By similarity). Involved in cell adhesion, cell motility and tumor metastasis (PubMed:7511626, PubMed:8478605). {ECO:0000250|UniProtKB:P40240, ECO:0000269|PubMed:12796480, ECO:0000269|PubMed:14575715, ECO:0000269|PubMed:18541721, ECO:0000269|PubMed:7511626, ECO:0000269|PubMed:8478605}.
uniprot
proteins
mass_dalton
25416
uniprot
proteins
mutagenesis
MUTAGEN 9; /note="C->A: Loss of palmitoylation; when associated with A-78; A-79; A-87; A-218 and A-219."; /evidence="ECO:0000269|PubMed:11959120"; MUTAGEN 78; /note="C->A: Loss of palmitoylation; when associated with A-9; A-79; A-87; A-218 and A-219."; /evidence="ECO:0000269|PubMed:11959120"; MUTAGEN 79; /note="C->A: Loss of palmitoylation; when associated with A-9; A-78; A-87; A-218 and A-219."; /evidence="ECO:0000269|PubMed:11959120"; MUTAGEN 87; /note="C->A: Loss of palmitoylation; when associated with A-9; A-78; A-79; A-218 and A-219."; /evidence="ECO:0000269|PubMed:11959120"; MUTAGEN 218; /note="C->A: Loss of palmitoylation; when associated with A-9; A-78; A-79; A-87 and A-219."; /evidence="ECO:0000269|PubMed:11959120"; MUTAGEN 219; /note="C->A: Loss of palmitoylation; when associated with A-9; A-78; A-79; A-87 and A-218."; /evidence="ECO:0000269|PubMed:11959120
uniprot
proteins
post_translational_modification
PTM: Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro). The protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids (PubMed:11959120). Palmitoylation by ZDHHC2 regulates CD9 expression, association with other tetraspanin family proteins and function in cell adhesion (PubMed:18508921). {ECO:0000269|PubMed:11959120, ECO:0000269|PubMed:18508921}.
uniprot
proteins
protein_family
Tetraspanin (TM4SF) family
uniprot
proteins
pubmed
11278880
uniprot
proteins
pubmed
11504738
uniprot
proteins
pubmed
11959120
uniprot
proteins
pubmed
12796480
uniprot
proteins
pubmed
14556650
uniprot
proteins
pubmed
14575715
uniprot
proteins
pubmed
15196249
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1720807
uniprot
proteins
pubmed
1840589
uniprot
proteins
pubmed
18508921
uniprot
proteins
pubmed
18541721
uniprot
proteins
pubmed
19640571
uniprot
proteins
pubmed
2037603
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
2358073
uniprot
proteins
pubmed
23858057
uniprot
proteins
pubmed
25551757
uniprot
proteins
pubmed
27993971
uniprot
proteins
pubmed
7511626
uniprot
proteins
pubmed
8478605
uniprot
proteins
pubmed
8486348
uniprot
proteins
sequence_length
228
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:19640571}; Multi-pass membrane protein {ECO:0000269|PubMed:19640571}. Membrane {ECO:0000269|PubMed:19640571}; Multi-pass membrane protein {ECO:0000269|PubMed:19640571}. Secreted, extracellular exosome {ECO:0000250|UniProtKB:P40240}. Note=Present at the cell surface of oocytes. Accumulates in the adhesion area between the sperm and egg following interaction between IZUMO1 and its receptor IZUMO1R/JUNO. {ECO:0000250|UniProtKB:P40240}.
uniprot
proteins
transmembrane_region
TRANSMEM 13..33; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 56..76; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 88..111; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 196..221; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins