MAGEA3
entrez
4102
canonical
uniprot
P43357
canonical
ensembl
ENSG00000221867
resolver
ensembl
ENSG00000292186
resolver
ensp
ENSP00000359301
resolver
ensp
ENSP00000473093
resolver
ensp
ENSP00000517961
resolver
ensp
ENSP00000517962
resolver
ensp
ENSP00000603948
resolver
enst
ENST00000370278
resolver
enst
ENST00000598245
resolver
enst
ENST00000709974
resolver
enst
ENST00000709975
resolver
enst
ENST00000933889
resolver
genesymbol
MAGEA3
resolver
genesymbol_syn
MAGE3
resolver
hgnc
HGNC:6801
resolver
uniprot
Q6FHI6
resolver
uniprot_entry
MAGA3_HUMAN
resolver
uniprot_sec
Q6FHI6
resolver
amino_acid_sequence
MPLEQRSQHCKPEEGLEARGEALGLVGAQAPATEEQEAASSSSTLVEVTLGEVPAAESPDPPQSPQGASSLPTTMNYPLWSQSYEDSSNQEEEGPSTFPDLESEFQAALSRKVAELVHFLLLKYRAREPVTKAEMLGSVVGNWQYFFPVIFSKASSSLQLVFGIELMEVDPIGHLYIFATCLGLSYDGLLGDNQIMPKAGLLIIVLAIIAREGDCAPEEKIWEELSVLEVFEGREDSILGDPKKLLTQHFVQENYLEYRQVPGSDPACYEFLWGPRALVETSYVKVLHHMVKISGGPHISYPPLHEWVLREGEE
uniprot
proteins
function
FUNCTION: Activator of ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases that acts as a repressor of autophagy (PubMed:20864041, PubMed:31267705). May enhance ubiquitin ligase activity of TRIM28 and stimulate p53/TP53 ubiquitination by TRIM28. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:17942928, PubMed:20864041). May play a role in embryonal development and tumor transformation or aspects of tumor progression (PubMed:17942928, PubMed:20864041). In vitro promotes cell viability in melanoma cell lines (PubMed:17942928). Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes (PubMed:8113684). {ECO:0000269|PubMed:17942928, ECO:0000269|PubMed:20864041, ECO:0000269|PubMed:31267705, ECO:0000269|PubMed:8113684}.
uniprot
proteins
mass_dalton
34747
uniprot
proteins
mutagenesis
MUTAGEN 170; /note="D->A: Abolishes HLA-A1 binding."; /evidence="ECO:0000269|PubMed:8113684"; MUTAGEN 176; /note="Y->A: Abolishes HLA-A1 binding."; /evidence="ECO:0000269|PubMed:8113684"; MUTAGEN 314; /note="E->EDNYNEPKANQ: Abolished recognition by the DCX(DCAF12) complex and ubiquitination."; /evidence="ECO:0000269|PubMed:31267705
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by the DCX(DCAF12) complex specifically recognizes the diglutamate (Glu-Glu) at the C-terminus, leading to its degradation. {ECO:0000269|PubMed:29779948, ECO:0000269|PubMed:31267705}.
uniprot
proteins
pubmed
10854409
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15772651
uniprot
proteins
pubmed
17942928
uniprot
proteins
pubmed
20864041
uniprot
proteins
pubmed
29779948
uniprot
proteins
pubmed
31267705
uniprot
proteins
pubmed
8037761
uniprot
proteins
pubmed
8113684
uniprot
proteins
sequence_length
314
uniprot
proteins