Nr0b2
entrez
117274
canonical
uniprot
P97947
canonical
ensembl
ENSRNOG00000007229
resolver
ensembl
ENSRNOG00055025765
resolver
ensembl
ENSRNOG00060030410
resolver
ensembl
ENSRNOG00065023452
resolver
ensp
ENSRNOP00000009683
resolver
ensp
ENSRNOP00055036343
resolver
ensp
ENSRNOP00060043891
resolver
ensp
ENSRNOP00065032576
resolver
enst
ENSRNOT00000009683
resolver
enst
ENSRNOT00055044436
resolver
enst
ENSRNOT00060052804
resolver
enst
ENSRNOT00065040071
resolver
genesymbol
Nr0b2
resolver
genesymbol_syn
Shp
resolver
uniprot_entry
NR0B2_RAT
resolver
amino_acid_sequence
MSSSQSGVCPCQGSASHPTILYTLLSPGPRTRPMAPASRSHCLCQQHRPVRLCAPHRTCREALDVLGKTVAFLRNLPSFCLLPHEDQRRLLEGCWGPLFLLGLAQDTVTFEVAEAPVPSILKKILLEEPNSGAQGAQPPDPPQPSLAAVQWLQHCLESFWSLELGPKEYAYLKGTILFNPDVPGLHASCHIAHLQQEAHWALCEVLEPWYPASQGRLARILLMASTLKNISCTLLVDLFFRPVIGDVDITELLEDMLLLR
uniprot
proteins
function
FUNCTION: Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways (By similarity). Specifically inhibits transactivation of the nuclear receptor with which it interacts (By similarity). Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1 (By similarity). Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2-mediated hepatic lipid metabolism (By similarity). Regulates the circadian expression of cytochrome P450 (CYP) enzymes (By similarity). Represses: NR5A2 and HNF4A to down-regulate CYP2C38, NFLI3 to up-regulate CYP2A5, BHLHE41/HNF1A axis to up-regulate CYP1A2, CYP2E1 and CYP3A11, and NR1D1 to up-regulate CYP2B10, CYP4A10 and CYP4A14 (By similarity). {ECO:0000250|UniProtKB:Q15466, ECO:0000250|UniProtKB:Q62227}.
uniprot
proteins
mass_dalton
28750
uniprot
proteins
post_translational_modification
PTM: Arginine methylation by PRMT5 enhances repression activity of metabolic genes in liver in response to bile acid signaling, by increasing interaction with cofactors. {ECO:0000250|UniProtKB:Q62227}.
uniprot
proteins
protein_family
NR0 subfamily
uniprot
proteins
protein_family
Nuclear hormone receptor family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15721253
uniprot
proteins
pubmed
15976031
uniprot
proteins
pubmed
9003453
uniprot
proteins
sequence_length
260
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q15466}. Nucleus {ECO:0000305}. Note=Colocalizes with NEUROD1 in the nucleus. {ECO:0000250|UniProtKB:Q15466}.
uniprot
proteins