Tor1a
entrez
30931
canonical
uniprot
Q9ER39
canonical
ensembl
ENSMUSG00000026849
resolver
ensp
ENSMUSP00000028200
resolver
enst
ENSMUST00000028200
resolver
genesymbol
Tor1a
resolver
genesymbol_syn
Dyt1
resolver
uniprot
Q3TV62
resolver
uniprot_entry
Q3TV62_MOUSE
resolver
uniprot_entry
TOR1A_MOUSE
resolver
amino_acid_sequence
MKLGRAALALLLLAPCVVRAVEPISLSLALAGVLTTYISYPRLYCLFAECCGQMRSLSREALQKDLDNKLFGQHLAKKVILNAVSGFLSNPKPKKPLTLSLHGWTGTGKNFASKIIAENIYEGGLNSDYVHLFVATLHFPHASNITQYKDQLQMWIRGNVSACARSIFIFDEMDKMHAGLIDAIKPFLDYYDVVDEVSYQKAIFIFLSNAGAERITDVALDFWKSGKQREEIKLRDMEPALAVSVFNNKNSGFWHSSLIDRNLIDYFVPFLPLEYKHLKMCIRVEMQSRGYEVDEDIISKVAEEMTFFPKEEKVFSDKGCKTVFTKLDYYLDD
uniprot
proteins
ec_number
3.6.4.-
uniprot
proteins
function
FUNCTION: Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues. {ECO:0000269|PubMed:16364897, ECO:0000269|PubMed:17200151, ECO:0000269|PubMed:17428918, ECO:0000269|PubMed:18827015, ECO:0000269|PubMed:20457914}.
uniprot
proteins
mass_dalton
37830
uniprot
proteins
mutagenesis
MUTAGEN 304; /note="Missing: Nuclear envelope abnormalities specific to neurons."; /evidence="ECO:0000269|PubMed:16364897
uniprot
proteins
post_translational_modification
PTM: N-glycosylated. {ECO:0000269|PubMed:20015956}.
uniprot
proteins
protein_family
ClpA/ClpB family
uniprot
proteins
protein_family
Torsin subfamily
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16364897
uniprot
proteins
pubmed
17200151
uniprot
proteins
pubmed
17428918
uniprot
proteins
pubmed
18827015
uniprot
proteins
pubmed
19535332
uniprot
proteins
pubmed
20015956
uniprot
proteins
pubmed
20457914
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
333
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen {ECO:0000250|UniProtKB:O14656}. Nucleus membrane; Peripheral membrane protein. Cell projection, growth cone. Cytoplasmic vesicle membrane {ECO:0000250}. Synapse, synaptosome {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle {ECO:0000250}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250}. Note=Upon oxidative stress, redistributes to protusions from the cell surface (By similarity). Peripherally associated with the inner face of the ER membrane, probably mediated by the interaction with TOR1AIP1. The association with nucleus membrane is mediated by the interaction with TOR1AIP2. {ECO:0000250}.
uniprot
proteins