Adrb1
entrez
24925
canonical
uniprot
P18090
canonical
ensembl
ENSRNOG00000017002
resolver
ensp
ENSRNOP00000022813
resolver
ensp
ENSRNOP00000082710
resolver
ensp
ENSRNOP00000098975
resolver
ensp
ENSRNOP00000104540
resolver
ensp
ENSRNOP00000104543
resolver
ensp
ENSRNOP00000105435
resolver
ensp
ENSRNOP00000106579
resolver
ensp
ENSRNOP00000109573
resolver
ensp
ENSRNOP00000109706
resolver
ensp
ENSRNOP00000112757
resolver
enst
ENSRNOT00000022813
resolver
enst
ENSRNOT00000102657
resolver
enst
ENSRNOT00000123057
resolver
enst
ENSRNOT00000133911
resolver
enst
ENSRNOT00000136976
resolver
enst
ENSRNOT00000139443
resolver
enst
ENSRNOT00000139837
resolver
enst
ENSRNOT00000151103
resolver
enst
ENSRNOT00000152890
resolver
enst
ENSRNOT00000173091
resolver
genesymbol
Adrb1
resolver
genesymbol_syn
Adrb1r
resolver
uniprot
A0A0G2JSP7
resolver
uniprot_entry
A0A0G2JSP7_RAT
resolver
uniprot_entry
ADRB1_RAT
resolver
amino_acid_sequence
MGAGALALGASEPCNLSSAAPLPDGAATAARLLVLASPPASLLPPASEGSAPLSQQWTAGMGLLLALIVLLIVVGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITLPFRYQSLLTRARARALVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLTGPPRPPSPAPSPSPGPPRPADSLANGRSSKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRDLVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQRLLCCARRAACRRRAAHGDRPRASGCLARAGPPPSPGAPSDDDDDDAGATPPARLLEPWAGCNGGTTTVDSDSSLDEPGRQGFSSESKV
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for catecholamines that couples to G(s) proteins to activate adenylate cyclase and cAMP-dependent pathway (By similarity). Binds epinephrine and norepinephrine with approximately equal affinity (PubMed:1695899). Mediates the activation of Ras via binding with cAMP-dependent RAPGEF2. As part of the sympathetic nervous system, plays a role in the physiologic regulation of cardiac functions such as stimulation of cardiomyocyte contraction (By similarity). Also delivers proapoptotic signals in cardiomyocytes (By similarity). Involved in the regulation of sleep/wake behaviors (By similarity). {ECO:0000250|UniProtKB:P08588, ECO:0000250|UniProtKB:P34971, ECO:0000269|PubMed:1695899}.
uniprot
proteins
mass_dalton
50472
uniprot
proteins
mutagenesis
MUTAGEN 466; /note="V->A: Abolishes interaction with MAGI3."; /evidence="ECO:0000269|PubMed:16316992
uniprot
proteins
post_translational_modification
PTM: Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase.
uniprot
proteins
protein_family
ADRB1 sub-subfamily
uniprot
proteins
protein_family
Adrenergic receptor subfamily
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12391161
uniprot
proteins
pubmed
16316992
uniprot
proteins
pubmed
1695899
uniprot
proteins
pubmed
2167473
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
466
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12391161}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P08588}. Note=Colocalizes with RAPGEF2 at the plasma membrane. Localized at the plasma membrane (PubMed:12391161). Found in the Golgi upon GOPC overexpression. Localized to early endosomes during endocytic trafficking (By similarity). {ECO:0000250|UniProtKB:P08588, ECO:0000269|PubMed:12391161}.
uniprot
proteins
transmembrane_region
TRANSMEM 58..81; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P08588"; TRANSMEM 96..121; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P08588"; TRANSMEM 129..154; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P08588"; TRANSMEM 177..199; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P08588"; TRANSMEM 222..245; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P08588"; TRANSMEM 313..338; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P08588"; TRANSMEM 347..366; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P08588
uniprot
proteins