SPON2
entrez
10417
canonical
uniprot
Q9BUD6
canonical
ensembl
ENSG00000159674
resolver
ensp
ENSP00000290902
resolver
ensp
ENSP00000394832
resolver
ensp
ENSP00000483599
resolver
enst
ENST00000290902
resolver
enst
ENST00000431380
resolver
enst
ENST00000617421
resolver
genesymbol
SPON2
resolver
genesymbol_syn
DIL1
resolver
hgnc
HGNC:11253
resolver
uniprot
D3DVN9
resolver
uniprot
Q4W5N4
resolver
uniprot
Q9ULW1
resolver
uniprot_entry
SPON2_HUMAN
resolver
uniprot_sec
D3DVN9
resolver
uniprot_sec
Q4W5N4
resolver
uniprot_sec
Q9ULW1
resolver
amino_acid_sequence
MENPSPAAALGKALCALLLATLGAAGQPLGGESICSARALAKYSITFTGKWSQTAFPKQYPLFRPPAQWSSLLGAAHSSDYSMWRKNQYVSNGLRDFAERGEAWALMKEIEAAGEALQSVHAVFSAPAVPSGTGQTSAELEVQRRHSLVSFVVRIVPSPDWFVGVDSLDLCDGDRWREQAALDLYPYDAGTDSGFTFSSPNFATIPQDTVTEITSSSPSHPANSFYYPRLKALPPIARVTLVRLRQSPRAFIPPAPVLPSRDNEIVDSASVPETPLDCEVSLWSSWGLCGGHCGRLGTKSRTRYVRVQPANNGSPCPELEEEAECVPDNCV
uniprot
proteins
function
FUNCTION: Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS). {ECO:0000250}.
uniprot
proteins
mass_dalton
35788
uniprot
proteins
mutagenesis
MUTAGEN 42; /note="K->A: Strongly reduced metal-dependent interaction with integrin; when associated with A-141."; /evidence="ECO:0000269|PubMed:19153605"; MUTAGEN 141; /note="E->A: Strongly reduced metal-dependent interaction with integrin; when associated with A-42."; /evidence="ECO:0000269|PubMed:19153605
uniprot
proteins
pubmed
10512675
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15815621
uniprot
proteins
pubmed
19153605
uniprot
proteins
sequence_length
331
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}.
uniprot
proteins