Ppp2r5b
entrez
309179
canonical
uniprot
Q80W83
canonical
ensembl
ENSRNOG00000021025
resolver
ensembl
ENSRNOG00055022204
resolver
ensembl
ENSRNOG00060032638
resolver
ensembl
ENSRNOG00065028547
resolver
ensp
ENSRNOP00000028542
resolver
ensp
ENSRNOP00055031099
resolver
ensp
ENSRNOP00060046739
resolver
ensp
ENSRNOP00065040364
resolver
enst
ENSRNOT00000028542
resolver
enst
ENSRNOT00055038161
resolver
enst
ENSRNOT00060056573
resolver
enst
ENSRNOT00065049223
resolver
genesymbol
Ppp2r5b
resolver
genesymbol_syn
LOC100909468
resolver
uniprot_entry
2A5B_RAT
resolver
amino_acid_sequence
METKLPPASTPTSPSSPGLSPVPPPDKVDGFSRRSLRRARPRRSHSSSQFRYQSNQQELTPLPLLKDVPASELHELLSRKLAQCGVMFDFLDCVADLKGKEVKRAALNELVECVGSTRGVLIEPVYPDIIRMISVNIFRTLPPSENPEFDPEEDEPNLEPSWPHLQLVYEFFLRFLESPDFQPSVAKRYVDQKFVLMLLELFDSEDPREREYLKTILHRVYGKFLGLRAYIRKQCNHIFLRFIYELEHFNGVAELLEILGSIINGFALPLKTEHKQFLVRVLIPLHSVKSLSVFHAQLAYCVVQFLEKDATLTEHVIRGLLKYWPKTCTQKEVMFLGEMEEILDVIEPSQFVKIQEPLFKQVARCVSSPHFQVAERALYFWNNEYILSLIEDNCHTVLPAVFGTLYQVSKEHWNQTIVSLIYNVLKTFMEMNGKLFDELTASYKLEKQQEQQKAQERQELWRGLEELRLRRLQGTQGAKEAPVPRPTPQVAASGGQS
uniprot
proteins
function
FUNCTION: As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation. {ECO:0000250|UniProtKB:Q15173}.
uniprot
proteins
mass_dalton
57326
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by CUL3-KLHL15 complex; this modification leads to proteasomal degradation. {ECO:0000250|UniProtKB:Q15173}.
uniprot
proteins
protein_family
Phosphatase 2A regulatory subunit B56 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16129692
uniprot
proteins
pubmed
23135275
uniprot
proteins
sequence_length
497
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q15173}.
uniprot
proteins