Mrgpre
entrez
244238
canonical
uniprot
Q91ZB7
canonical
ensembl
ENSMUSG00000048965
resolver
ensp
ENSMUSP00000058000
resolver
ensp
ENSMUSP00000192851
resolver
enst
ENSMUST00000054048
resolver
genesymbol
Mrgpre
resolver
genesymbol_syn
Ebrt3
resolver
genesymbol_syn
Mrge
resolver
uniprot
Q4V9R2
resolver
uniprot
Q711I9
resolver
uniprot_entry
MRGRE_MOUSE
resolver
uniprot_entry
Q4V9R2_MOUSE
resolver
uniprot_sec
Q711I9
resolver
amino_acid_sequence
MTSLSVHTDSPSTQGEMAFNLTILSLTELLSLGGLLGNGVALWLLNQNVYRNPFSIYLLDVACADLIFLCCHMVAIIPELLQDQLNFPEFVHISLTMLRFFCYIVGLSLLAAISTEQCLATLFPAWYLCRRPRYLTTCVCALIWVLCLLLDLLLSGACTQFFGAPSYHLCDMLWLVVAVLLAALCCTMCVTSLLLLLRVERGPERHQPRGFPTLVLLAVLLFLFCGLPFGIFWLSKNLSWHIPLYFYHFSFFMASVHSAAKPAIYFFLGSTPGQRFREPLRLVLQRALGDEAELGAGREASQGGLVDMTV
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for L-tryptophanocholate (Trp-CA), an amino-acid-conjugated bile acid produced by the microbiome, which regulates glucose homeostasis (PubMed:40446798). Expressed in enteroendocrine L cells of the gut epithelium: Trp-CA binding causes a conformation change that triggers signaling via G(s) G protein, mediating activation of adenylate cyclase activity (PubMed:40446798). In addition to G(s), MRGPRE also associates with beta-arrestin-1 (ARRB1), promoting phosphorylation of ALDOA (PubMed:40446798). Both G(s) and beta-arrestin-1 signaling pathways improves glucose tolerance by enhancing GLP-1 secretion (PubMed:40446798). {ECO:0000269|PubMed:40446798}.
uniprot
proteins
mass_dalton
34588
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
protein_family
Mas subfamily
uniprot
proteins
pubmed
11551509
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
18197975
uniprot
proteins
pubmed
40446798
uniprot
proteins
sequence_length
310
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:40446798}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 23..43; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 61..81; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 93..113; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 134..154; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 175..195; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 214..234; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 249..269; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins