Itgb1
entrez
16412
canonical
uniprot
P09055
canonical
ensembl
ENSMUSG00000025809
resolver
ensp
ENSMUSP00000087457
resolver
genesymbol
Itgb1
resolver
uniprot
F6R105
resolver
uniprot
Q3TIW5
resolver
uniprot
Q3TWH6
resolver
uniprot
Q60993
resolver
uniprot
Q61126
resolver
uniprot
Q8BTU0
resolver
uniprot
Q8BVU1
resolver
uniprot_entry
ITB1_MOUSE
resolver
uniprot_sec
F6R105
resolver
uniprot_sec
Q3TIW5
resolver
uniprot_sec
Q3TWH6
resolver
uniprot_sec
Q60993
resolver
uniprot_sec
Q61126
resolver
uniprot_sec
Q8BTU0
resolver
uniprot_sec
Q8BVU1
resolver
amino_acid_sequence
MNLQLVSWIGLISLICSVFGQTDKNRCLKANAKSCGECIQAGPNCGWCTNTTFLQEGMPTSARCDDLEALKKKGCQPSDIENPRGSQTIKKNKNVTNRSKGMAEKLRPEDITQIQPQQLLLKLRSGEPQKFTLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNVLSLTDRGEFFNELVGQQRISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQCHLENNVYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSGNSSNVIQLIIDAYNSLSSEVILENSKLPDGVTINYKSYCKNGVNGTGENGRKCSNISIGDEVQFEISITANKCPNKESETIKIKPLGFTEEVEVVLQFICKCNCQSHGIPASPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVNSEDMDAYCRKENSSEICSNNGECVCGQCVCRKRDNTNEIYSGKFCECDNFNCDRSNGLICGGNGVCRCRVCECYPNYTGSACDCSLDTGPCLASNGQICNGRGICECGACKCTDPKFQGPTCETCQTCLGVCAEHKECVQCRAFNKGEKKDTCAQECSHFNLTKVESREKLPQPVQVDPVTHCKEKDIDDCWFYFTYSVNGNNEAIVHVVETPDCPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNPKYEGK
uniprot
proteins
function
FUNCTION: Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (PubMed:10634791, PubMed:36812915). Integrin alpha-4/beta-1 is a receptor for VCAM1 and recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition (PubMed:12941630). Involved in promoting endothelial cell motility and angiogenesis (PubMed:15181153). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules (PubMed:21768292). May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis (PubMed:18804435). ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (By similarity). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (By similarity). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). ITGA5:ITGB1 acts as a receptor for fibronectin FN1 and mediates R-G-D-dependent cell adhesion to FN1 (By similarity). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (By similarity). ITGA5:ITGB3 is a receptor for soluble CD40LG and is required for CD40/CD40LG signaling (By similarity). ITGA5:ITGB1 acts as a receptor for SNED1 and mediates R-G-D-dependent cell adhesion to SNED1 (By similarity) Plays an important role in myoblast differentiation and fusion during skeletal myogenesis (By similarity). ITGA9:ITGB1 may play a crucial role in SVEP1/polydom-mediated myoblast cell adhesion (PubMed:22654117). Integrins ITGA9:ITGB1 and ITGA4:ITGB1 repress PRKCA-mediated L-type voltage-gated channel Ca(2+) influx and ROCK-mediated calcium sensitivity in vascular smooth muscle cells via their interaction with SVEP1, thereby inhibit vasocontraction (PubMed:35802072). {ECO:0000250|UniProtKB:P05556, ECO:0000250|UniProtKB:P07228, ECO:0000269|PubMed:10634791, ECO:0000269|PubMed:12941630, ECO:0000269|PubMed:15181153, ECO:0000269|PubMed:18804435, ECO:0000269|PubMed:19903482, ECO:0000269|PubMed:21768292, ECO:0000269|PubMed:22654117, ECO:0000269|PubMed:35802072, ECO:0000269|PubMed:36812915}.; FUNCTION: [Isoform 2]: Isoform 2 displaces isoform 1 in striated muscles. {ECO:0000269|PubMed:8567725}.
uniprot
proteins
mass_dalton
88231
uniprot
proteins
mutagenesis
MUTAGEN 783; /note="Y->F: Reduced endocytosis; when associated with F-795."; /evidence="ECO:0000269|PubMed:18804435"; MUTAGEN 795; /note="Y->F: Reduced endocytosis; when associated with F-783."; /evidence="ECO:0000269|PubMed:18804435
uniprot
proteins
protein_family
Integrin beta chain family
uniprot
proteins
pubmed
10634791
uniprot
proteins
pubmed
11805835
uniprot
proteins
pubmed
12189152
uniprot
proteins
pubmed
12941630
uniprot
proteins
pubmed
15181153
uniprot
proteins
pubmed
15466886
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15734730
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17947660
uniprot
proteins
pubmed
18483218
uniprot
proteins
pubmed
18804435
uniprot
proteins
pubmed
19144319
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19656770
uniprot
proteins
pubmed
19903482
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
21768292
uniprot
proteins
pubmed
22654117
uniprot
proteins
pubmed
2521606
uniprot
proteins
pubmed
2523953
uniprot
proteins
pubmed
28179430
uniprot
proteins
pubmed
3262537
uniprot
proteins
pubmed
34427057
uniprot
proteins
pubmed
35687021
uniprot
proteins
pubmed
35802072
uniprot
proteins
pubmed
36812915
uniprot
proteins
pubmed
38061240
uniprot
proteins
pubmed
39087467
uniprot
proteins
pubmed
8567725
uniprot
proteins
pubmed
8870969
uniprot
proteins
pubmed
9553049
uniprot
proteins
sequence_length
798
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P05556}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, invadopodium membrane {ECO:0000250|UniProtKB:P05556}; Single-pass type I membrane protein {ECO:0000255}. Cell projection, ruffle membrane {ECO:0000250|UniProtKB:P05556}; Single-pass type I membrane protein {ECO:0000255}. Recycling endosome {ECO:0000269|PubMed:21768292, ECO:0000269|PubMed:8567725}. Melanosome {ECO:0000250|UniProtKB:P05556}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:P05556}. Cell projection, ruffle {ECO:0000250|UniProtKB:P05556}. Cell junction, focal adhesion {ECO:0000250|UniProtKB:P05556}. Note=Colocalizes with ITGB1BP1 and metastatic suppressor protein NME2 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen. Translocates from peripheral focal adhesions to fibrillar adhesions in an ITGB1BP1-dependent manner. Enriched preferentially at invadopodia, cell membrane protrusions that correspond to sites of cell invasion, in a collagen-dependent manner. Localized at plasma and ruffle membranes in a collagen-independent manner. {ECO:0000250|UniProtKB:P05556}.; SUBCELLULAR LOCATION: [Isoform 2]: Cell membrane, sarcolemma {ECO:0000269|PubMed:8567725}. Cell junction {ECO:0000269|PubMed:8567725}. Note=In cardiac muscle, found in costameres and intercalated disks. {ECO:0000269|PubMed:8567725}.
uniprot
proteins
transmembrane_region
TRANSMEM 729..751; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins