Trpm1
entrez
17364
canonical
uniprot
Q2TV84
canonical
ensembl
ENSMUSG00000030523
resolver
ensp
ENSMUSP00000082318
resolver
ensp
ENSMUSP00000134947
resolver
genesymbol
Trpm1
resolver
genesymbol_syn
Ltrpc1
resolver
uniprot
O70334
resolver
uniprot
Q2WEA6
resolver
uniprot
Q3TPG5
resolver
uniprot
Q3UEW7
resolver
uniprot
Q3UFV6
resolver
uniprot
Q3UFW1
resolver
uniprot
Q3UG69
resolver
uniprot
Q5U4B3
resolver
uniprot
Q640P5
resolver
uniprot_entry
TRPM1_MOUSE
resolver
uniprot_sec
O70334
resolver
uniprot_sec
Q2WEA6
resolver
uniprot_sec
Q3TPG5
resolver
uniprot_sec
Q3UEW7
resolver
uniprot_sec
Q3UFV6
resolver
uniprot_sec
Q3UFW1
resolver
uniprot_sec
Q3UG69
resolver
uniprot_sec
Q5U4B3
resolver
uniprot_sec
Q640P5
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by extracellular zinc ions (By similarity). Inhibited by intracellular Mg(2+) (By similarity). Activated by the neuroactive steroid pregnenolone sulfate (By similarity). Negatively regulated by activation of GRM6 receptors in the ON-bipolar cells (PubMed:26883481). {ECO:0000250|UniProtKB:Q7Z4N2, ECO:0000269|PubMed:26883481}.
uniprot
proteins
amino_acid_sequence
MGSMRKMSSSFKRGSIKSSTSGSQKGQKAWIEKTFCKRECIFVIPSTKDPNRCCCGQLTNQHIPPLPSGAPSTTGEDTKQADTQSGKWSVSKHTQSYPTDSYGILEFQGGGYSNKAMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQSFEMQPKLKQVFGKGLIKAAMTTGAWIFTGGVSTGVVSHVGDALKDHSSKSRGRLCAIGIAPWGMVENKEDLIGKDVTRVYQTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRQLEKHISLQKINTRLGQGVPVVGLVVEGGPNVVSIVLEYLKEDPPVPVVVCDGSGRASDILSFAHKYCDEGGVINESLRDQLLVTIQKTFNYSKSQSYQLFAIIMECMKKKELVTVFRMGSEGQQDVEMAILTALLKGTNASAPDQLSLALAWNRVDIARSQIFVFGPHWPPLGSLAPPVDTKATEKEKKPPTATTKGRGKGKGKKKGKVKEEVEEETDPRKLELLNWVNALEQAMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDVKKSNLPPDYHISLIDIGLVLEYLMGGAYRCNYTRKSFRTLYNNLFGPKRPKALKLLGMEDDEPPAKGKKKKKKKKEEEIDIDVDDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEECMAKALVACKLYKAMAHESSESELVDDISQDLDNNSKDFGQLAVELLDQSYKHDEQVAMKLLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIMGILIPPTILFLEFRTYDDFSYQTSKENEDGKEKEEENVDANADAGSRKGDEENEHKKQRSIPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNYVILVRMDGWPSPQEWIVISYIVSLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAISMFMVGAILRLQSQPYMGYGRVIYCVDIILWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQAILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINPPCGENLYDEEGKRLPPCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTFHDRPVLPPPMIILSHIYIIIMRLSGRCRKKREGDQEERDRGLKLFLSDEELKKLHEFEEQCVQEHFREKEDEQQSSSDERIRVTSERVENMSMRLEEINERENFMKTSLQTVDLRLSQLEELSGRMVSALENLAGIDRSDLIQARSRASSECEATYLLRQSSINSADGYSLYRYHFNGEELLFEEPALSTSPGTAFRKKTYSFRVKDEDAKSHLDQPSNLHHTPGPSPPATPGRSRLALEGPLSTELRPGSDPGISAGEFDPRADFKSTEAAPSLNAAGVTGTQLTVESTDSHPLRESKLVRYYPGDPNTYKTMKSRSFVYTEGRKLVRGLSNWSAEYSSIMDQAWNATEWRCQVQRITRSRSTDIPYIVSEAASQDELEDEHRGSLLDPQISRSALTVSDRPEKENLLSVKPHQTLGFPCLRSRSLHGRPRSAEPAPSKLDRAGHASSTSNLAVMSVVPEGQNTQQEKRSAETEC
uniprot
proteins
function
FUNCTION: Constitutively open nonselective divalent cation-conducting channels which mediate the influx of Ca(2+), Mg(2+), Mn(2+), Ba(2+), and Ni(2+) into the cytoplasm, leading to membrane depolarization. Impermeable to zinc ions. In addition, forms heteromultimeric ion channels with TRPM3 which are permeable for calcium and zinc ions. Plays an essential role for the depolarizing photoresponse of retinal ON bipolar cells (PubMed:19861548). In the dark, tonic release of glutamate activates the G protein-coupled receptor for glutamate (GRM6), its activation induces the release of G(o) and the beta-gamma G protein dimer. Both subunits can interact and inactivate the TRPM1 channel. A light onset, induces decrease in glutamate release and deactivation of GRM6 leading to channel opening and membrane depolarization (PubMed:19966281, PubMed:26883481). May play a role in metastasis suppression (PubMed:9537257). {ECO:0000269|PubMed:19861548, ECO:0000269|PubMed:19966281, ECO:0000269|PubMed:26883481, ECO:0000269|PubMed:9537257}.
uniprot
proteins
mass_dalton
183527
uniprot
proteins
protein_family
LTrpC subfamily
uniprot
proteins
protein_family
TRPM1 sub-subfamily
uniprot
proteins
protein_family
Transient receptor (TC 1.A.4) family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15856355
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19861548
uniprot
proteins
pubmed
19966281
uniprot
proteins
pubmed
21734298
uniprot
proteins
pubmed
21832182
uniprot
proteins
pubmed
24114537
uniprot
proteins
pubmed
24790204
uniprot
proteins
pubmed
25112866
uniprot
proteins
pubmed
26883481
uniprot
proteins
pubmed
30027108
uniprot
proteins
pubmed
33122432
uniprot
proteins
pubmed
9537257
uniprot
proteins
sequence_length
1622
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q7Z4N2}; Multi-pass membrane protein {ECO:0000255}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:30027108}; Multi-pass membrane protein {ECO:0000255}. Cell projection, axon {ECO:0000269|PubMed:30027108}. Cell projection, dendrite {ECO:0000269|PubMed:21734298, ECO:0000269|PubMed:21832182}. Note=Localizes on dendritic tips of ON bipolar cells (PubMed:21832182). {ECO:0000250|UniProtKB:Q7Z4N2}.
uniprot
proteins
transmembrane_region
TRANSMEM 876..896; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 943..963; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 974..994; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1007..1027; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1100..1120; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 1151..1171; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins