P15331
uniprot
P15331
canonical
amino_acid_sequence
MPSSASMSHHHSSGLRSSISSTSYRRTFGPPPSLSPGAFSYSSSSRFSSSRLLGSGSPSSSARLGSFRAPRAGALRLPSERLDFSMAEALNQEFLATRSNEKQELQELNDRFANFIEKVRFLEQQNAALRGELSQARGQEPARADQLCQQELRELRRELELLGRERDRVQVERDGLAEDLAALKQRLEEETRKREDAEHNLVLFRKDVDDATLSRLELERKIESLMDEIEFLKKLHEEELRDLQVSVESQQVQQVEVEATVKPELTAALRDIRAQYENIAAKNLQEAEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVDGLRGTNEALLRQLRELEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEGEESRISVPVHSFASLSLKTTVPEMEPLQDSHSKKMVLIRTIETRDGEKVVTESQKEQHSDLDKSSIHSY
uniprot
proteins
function
FUNCTION: Class-III neuronal intermediate filament protein (By similarity). May form an independent structural network without the involvement of other neurofilaments or may cooperate with the neuronal intermediate filament proteins NEFL, NEFH, NEFM and INA to form filamentous networks (PubMed:10426285, PubMed:15322088, PubMed:22723690). Assembly of the neuronal intermediate filaments may be regulated by RAB7A (PubMed:23179371). Plays a role in the development of unmyelinated sensory neurons (PubMed:12065660). May be involved in axon elongation and axon regeneration after injury (By similarity). Inhibits neurite extension in type II spiral ganglion neurons in the cochlea (PubMed:20132868). {ECO:0000250|UniProtKB:P21807, ECO:0000269|PubMed:10426285, ECO:0000269|PubMed:12065660, ECO:0000269|PubMed:15322088, ECO:0000269|PubMed:20132868, ECO:0000269|PubMed:22723690, ECO:0000269|PubMed:23179371}.
uniprot
proteins
mass_dalton
54268
uniprot
proteins
mutagenesis
MUTAGEN 66; /note="S->A: Abolishes phosphorylation by AKT."; /evidence="ECO:0000269|PubMed:17569669
uniprot
proteins
post_translational_modification
PTM: Phosphorylated; phosphorylation increases after nerve injury in regenerating neurons. {ECO:0000250|UniProtKB:P21807}.
uniprot
proteins
protein_family
Intermediate filament family
uniprot
proteins
pubmed
10426285
uniprot
proteins
pubmed
12065660
uniprot
proteins
pubmed
1294287
uniprot
proteins
pubmed
15322088
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17569669
uniprot
proteins
pubmed
17899157
uniprot
proteins
pubmed
18709437
uniprot
proteins
pubmed
20132868
uniprot
proteins
pubmed
22723690
uniprot
proteins
pubmed
23179371
uniprot
proteins
pubmed
2767051
uniprot
proteins
pubmed
9971739
uniprot
proteins
sequence_length
475
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000269|PubMed:10426285, ECO:0000269|PubMed:15322088, ECO:0000269|PubMed:18709437, ECO:0000269|PubMed:20132868, ECO:0000269|PubMed:22723690, ECO:0000269|PubMed:23179371, ECO:0000269|PubMed:9971739}. Cell projection, axon {ECO:0000269|PubMed:17899157, ECO:0000269|PubMed:18709437, ECO:0000269|PubMed:20132868, ECO:0000269|PubMed:22723690, ECO:0000269|PubMed:23179371}. Perikaryon {ECO:0000269|PubMed:17899157, ECO:0000269|PubMed:18709437, ECO:0000269|PubMed:20132868}.
uniprot
proteins