Rbm4
entrez
19653
canonical
uniprot
Q8C7Q4
canonical
ensembl
ENSMUSG00000094936
resolver
ensp
ENSMUSP00000129745
resolver
ensp
ENSMUSP00000136254
resolver
ensp
ENSMUSP00000137174
resolver
ensp
ENSMUSP00000137345
resolver
enst
ENSMUST00000164209
resolver
enst
ENSMUST00000178615
resolver
genesymbol
Rbm4
resolver
genesymbol_syn
Rbm4a
resolver
uniprot
B7ZN14
resolver
uniprot
K9J7F7
resolver
uniprot
O08752
resolver
uniprot
Q5CZX8
resolver
uniprot
Q8BN66
resolver
uniprot_entry
B7ZN14_MOUSE
resolver
uniprot_entry
K9J7F7_MOUSE
resolver
uniprot_entry
Q5CZX8_MOUSE
resolver
uniprot_entry
RBM4_MOUSE
resolver
uniprot_sec
O08752
resolver
uniprot_sec
Q8BN66
resolver
amino_acid_sequence
MVKLFIGNLPREATEQEIRSLFEQYGKVLECDIIKNYGFVHIEDKTAAEDAIRNLHHYKLHGVNINVEASKNKSKASTKLHVGNISPTCTNQELRAKFEEYGPVIECDIVKDYAFVHMERAEDAVEAIRGLDNTEFQGKRMHVQLSTSRLRTAPGMGDQSGCYRCGKEGHWSKECPIDRSGRVADLTEQYNEQYGAVRTPYTMSYGDSLYYNNTYGALDAYYKRCRAARSYEAVAAAAASAYSNYAEQTLSQLPQVQNTAMASHLTSTSLDPYNRHLLPPSGAAAAAAAAAACTAASTSYYGRDRSPLRRATGPVLTVGEGYGYGHDSELSQASAAARNSLYDMARYEREQYADRARYSAF
uniprot
proteins
function
FUNCTION: RNA-binding factor involved in multiple aspects of cellular processes like alternative splicing of pre-mRNA and translation regulation. Modulates alternative 5'-splice site and exon selection. Acts as a muscle cell differentiation-promoting factor. Activates exon skipping of the PTB pre-mRNA during muscle cell differentiation. Antagonizes the activity of the splicing factor PTBP1 to modulate muscle cell-specific exon selection of alpha tropomyosin. Binds to intronic pyrimidine-rich sequence of the TPM1 and MAPT pre-mRNAs. Required for the translational activation of PER1 mRNA in response to circadian clock. Binds directly to the 3'-UTR of the PER1 mRNA. Exerts a suppressive activity on Cap-dependent translation via binding to CU-rich responsive elements within the 3'UTR of mRNAs, a process increased under stress conditions or during myocytes differentiation. Recruits EIF4A1 to stimulate IRES-dependent translation initiation in respons to cellular stress. Associates to internal ribosome entry segment (IRES) in target mRNA species under stress conditions. Plays a role for miRNA-guided RNA cleavage and translation suppression by promoting association of AGO2-containing miRNPs with their cognate target mRNAs. Associates with miRNAs during muscle cell differentiation. Binds preferentially to 5'-CGCGCG[GCA]-3' motif in vitro. {ECO:0000269|PubMed:17264215}.
uniprot
proteins
mass_dalton
40046
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylated in vitro on Ser-306 by SRPK1. Phosphorylation on Ser-306 is induced upon cell stress signaling, which alters its subcellular localization and may modulate its activity on IRES-mediated mRNA translation (By similarity). Phosphorylated. Phosphorylation on Ser-306 is induced upon cell muscle differentiation. {ECO:0000250, ECO:0000269|PubMed:19801630}.
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16260624
uniprot
proteins
pubmed
17264215
uniprot
proteins
pubmed
19801630
uniprot
proteins
pubmed
21518792
uniprot
proteins
pubmed
9169144
uniprot
proteins
sequence_length
361
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Nucleus speckle {ECO:0000250}. Cytoplasm {ECO:0000250}. Cytoplasmic granule {ECO:0000250}. Note=Undergoes continuous nucleocytoplasmic shuttling. Upon nuclear import colocalizes with SR proteins in nuclear speckles. Arsenite stress-induced phosphorylation increases its subcellular relocalization from the nucleus to the cytoplasm and to cytoplasmic stress granules (SG) via a p38 MAPK signaling pathway. Primarily localized in nucleus and nucleoli under cell growth conditions and accumulated in the cytoplasm and cytoplasm perinuclear granules upon muscle cell differentiation (By similarity). {ECO:0000250}.
uniprot
proteins