Shank2
entrez
171093
canonical
uniprot
Q9QX74
canonical
ensembl
ENSRNOG00000050206
resolver
ensembl
ENSRNOG00060028641
resolver
ensp
ENSRNOP00000067841
resolver
ensp
ENSRNOP00000075839
resolver
genesymbol
Shank2
resolver
genesymbol_syn
Cortbp1
resolver
uniprot
O70470
resolver
uniprot
Q6WB19
resolver
uniprot
Q9QX93
resolver
uniprot
Q9QZZ9
resolver
uniprot
Q9WUV9
resolver
uniprot
Q9WUW0
resolver
uniprot
Q9WV46
resolver
uniprot_entry
SHAN2_RAT
resolver
uniprot_sec
O70470
resolver
uniprot_sec
Q6WB19
resolver
uniprot_sec
Q9QX93
resolver
uniprot_sec
Q9QZZ9
resolver
uniprot_sec
Q9WUV9
resolver
uniprot_sec
Q9WUW0
resolver
uniprot_sec
Q9WV46
resolver
amino_acid_sequence
MKSLLNAFTKKEVPFREAPAYSNRRRRPPNTLAAPRVLLRSNSDNNLNAGAPEWAVCSAATSHRSLSPQLLQQTPSKPDGATKSLGSYAPGPRSRSPSLNRLGGAGEDGKRPQPPHWHVGSPFTPGANKDSLSTFEYPGPRRKLYSAVPGRLFVAIKPYQPQVDGEIPLHRGDRVKVLSIGEGGFWEGSARGHIGWFPAECVEEVQCKPRDSQAETRADRSKKLFRHYTVGSYDSFDAASDCIIEDKTVVLQKKDNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNNENVVKVGHRQVVNMIRQGGNHLVLKVVTVTRNLDPDDTARKKAPPPPKRAPTTALTLRSKSMTAELEELGLSLVDKASVRKKKDKPEEIVPASKPSRTAENVAIESRVATIKQRPTSRCFPAASDVNSVYERQGIAVMTPTVPGSPKGPFLGLPRGTMRRQKSIDSRIFLSGITEEERQFLAPPMLKFTRSLSMPDTSEDIPPPPQSVPPSPPPPSPTTYNCPRSPTPRVYGTIKPAFNQNPVAKVPPATRSDTVATMMREKGMFYRRELDRFSLDSEDVYSRSPAPQAAFRTKRGQMPENPYSEVGKIASKAVYVPAKPARRKGMLVKQSNVEDSPEKTCSIPIPTIIVKEPSTSSSGKSSQGSSMEIDPQATEPGQLRPDDSLTVSSPFAAAIAGAVRDREKRLEARRNSPAFLSTDLGDEDVGLGPPAPRMQPSKFPEEGGFGDEDETEQPLLPTPGAAPRELENHFLGGGEAGAQGEAGGPLSSTSKAKGPESGPAAALKSSSPASPENYVHPLTGRLLDPSSPLALALSARDRAMQESQQGHKGEAPKADLNKPLYIDTKMRPSVESGFPPVTRQNTRGPLRRQETENKYETDLSKDRRADDKKNMLINIVDTAQQKSAGLLMVHTVDIPVAGPPLEEEEDREDGDTKPDHSPSTVPEGVPKTEGALQISAAPEPAAAPGRTIVAAGSVEEAVILPFRIPPPPLASVDLDEDFLFTEPLPPPLEFANSFDIPDDRAASVPALADLVKQKKSDTPQPPSLNSSQPANSTDSKKPAGISNCLPSSFLPPPESFDAVTDSGIEEVDSRSSSDHHLETTSTISTVSSISTLSSEGGESMDTCTVYADGQAFVVDKPPVPPKPKMKPIVHKSNALYQDTLPEEDTDGFVIPPPAPPPPPGSAQAGVAKVIQPRTSKLWGDVTEVKSPILSGPKANVISELNSILQQMNRGKSVKPGEGLELPVGAKSANLAPRSPEVMSTVSGTRSTTVTFTVRPGTSQPITLQSRPPDYESRTSGPRRAPSPVVSPTELSKEILPTPPSAAAASPSPTLSDVFSLPSQSPAGDLFGLNPAGRSRSPSPSILQQPISNKPFTTKPVHLWTKPDVADWLESLNLGEHKETFMDNEIDGSHLPNLQKEDLIDLGVTRVGHRMNIERALKQLLDR
uniprot
proteins
function
FUNCTION: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. {ECO:0000269|PubMed:10506216}.
uniprot
proteins
mass_dalton
158684
uniprot
proteins
protein_family
SHANK family
uniprot
proteins
pubmed
10414979
uniprot
proteins
pubmed
10506216
uniprot
proteins
pubmed
10527873
uniprot
proteins
pubmed
10806096
uniprot
proteins
pubmed
10958799
uniprot
proteins
pubmed
10964907
uniprot
proteins
pubmed
14679199
uniprot
proteins
pubmed
14977424
uniprot
proteins
pubmed
15014124
uniprot
proteins
pubmed
15632121
uniprot
proteins
pubmed
16293618
uniprot
proteins
pubmed
16758162
uniprot
proteins
pubmed
17244609
uniprot
proteins
pubmed
17304222
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
9742101
uniprot
proteins
sequence_length
1474
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Apical cell membrane {ECO:0000269|PubMed:17244609}. Cytoplasm {ECO:0000269|PubMed:17244609}. Synapse {ECO:0000269|PubMed:17244609}. Postsynaptic density {ECO:0000269|PubMed:17244609}. Cell projection, growth cone {ECO:0000269|PubMed:17244609}. Cell projection, dendritic spine {ECO:0000250}. Note=Colocalizes with cortactin in growth cones in differentiating hippocampal neurons. Present in the dendritic spines of cerebellar Purkinje cells (By similarity). Colocalizes with cortactin in growth cones in differentiating hippocampal neurons. Colocalized with PDE4D to the apical membrane of colonic crypt cells. {ECO:0000250}.
uniprot
proteins