Plcd4
entrez
140693
canonical
uniprot
Q62711
canonical
ensembl
ENSRNOG00000016361
resolver
ensp
ENSRNOP00000039708
resolver
ensp
ENSRNOP00000102316
resolver
enst
ENSRNOT00000132597
resolver
genesymbol
Plcd4
resolver
uniprot
A0ABK0LHB6
resolver
uniprot
Q63693
resolver
uniprot_entry
A0ABK0LHB6_RAT
resolver
uniprot_entry
PLCD4_RAT
resolver
uniprot_sec
Q63693
resolver
amino_acid_sequence
MASQIQKLLTTNQDLLLMQKGTMMRKVRTKSWKKLRYFRLQDDGMTVWHGRHLESISKPTFSISDVERIRKGQDSELLRYLVEEFPLEQGFTIVFNGRRPNLDLVANSVEEAQTWMRGLQLLVDLVARMNYQEQLDQMLREWFQQADRNQDSRMSFREAQRLLLLMNVEMDEEYAFSLFQEADVSQSNTLDSEEFVQFYKALTKRTEIEELFENFSSDKQKLTLLEFVDFLREEQKESDHSSDLALKLIDRYEPSENGRLLRVLSKDGFLSYLCSADGNIFNPDCLPIYQDMTQPLSHYYINSSHNTYLLGDQFCGQSSVEGYIRALKRGCRCVEVDTWDGPDGEPVVYHGRTLTSRILFKDVLATLAQYAFQSSDYPLILSLDNHCTWEQQKTMAHHLIAILGEQLLSTTLEEQLIDIMPSPEQLRGKILVKGKKLRTIEVVESDKEEEELEKDEGSDLDPASAELDMQSQPESQEQASGNKSKNKKKFLLQSSTTILCPDLSALVVYLRTAPFCSFTHSKENYHIYDISSFSESKAKNLIREAGNEFVQHNARQLCRVYPSGLRTDSSNYNPQEHWNVGCQMVAMNMQTAGSAMDICDGLFRQNGGSGYVLKPEFLRDTQSSFNPMKPVSLYKAQILVVQVISGQRLPKVDKTKETTVVDPLVRVELYGVPEDTKQQETSYVENNGINPYWGETFYFQIQVPELAMLRFVVKDYSRTSRNNFIGQYTLPWTCMKHGYRHVSLLSKDGTSLHPASIFVYTCMQEDLDMDEP
uniprot
proteins
ec_number
3.1.4.11
uniprot
proteins
function
FUNCTION: Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida-induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation. {ECO:0000269|PubMed:8550568}.; FUNCTION: [Isoform 4]: Has no enzyme activity and acts as a negative regulator of phospholipase C, with a preference for thePLC-delta family. {ECO:0000269|PubMed:9915823}.
uniprot
proteins
mass_dalton
88967
uniprot
proteins
mutagenesis
MUTAGEN 36; /note="R->G: Only retains weak enzyme activity and abolishes the ability of isoform 4 to act as a negative regulator."; /evidence="ECO:0000269|PubMed:9915823"; MUTAGEN 714; /note="K->E: Abolishes affinity for POPC/POPS in the absence of Ca(2+); when associated with E-718."; /evidence="ECO:0000269|PubMed:11706040"; MUTAGEN 717; /note="S->D: Induces a larger Ca(2+)-dependence."; /evidence="ECO:0000269|PubMed:11706040"; MUTAGEN 718; /note="R->E: Abolishes affinity for POPC/POPS in the absence of Ca(2+); when associated with E-714."; /evidence="ECO:0000269|PubMed:11706040
uniprot
proteins
pubmed
11706040
uniprot
proteins
pubmed
15037625
uniprot
proteins
pubmed
17063484
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
8550568
uniprot
proteins
pubmed
8550586
uniprot
proteins
pubmed
9915823
uniprot
proteins
sequence_length
772
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:11706040}; Peripheral membrane protein {ECO:0000269|PubMed:11706040}; Cytoplasmic side {ECO:0000305|PubMed:11706040}. Nucleus {ECO:0000269|PubMed:15037625}. Cytoplasm {ECO:0000250|UniProtKB:Q9BRC7}. Endoplasmic reticulum {ECO:0000269|PubMed:15037625}. Note=The C2 domain mediates pre-localization to the membrane prior to Ca(2+) import and non-selective Ca(2+)-mediated targeting to various cellular membranes (PubMed:11706040). Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum (PubMed:15037625). {ECO:0000269|PubMed:11706040, ECO:0000269|PubMed:15037625}.
uniprot
proteins