GADD45GIP1
entrez
90480
canonical
uniprot
Q8TAE8
canonical
ensembl
ENSG00000179271
resolver
ensp
ENSP00000323065
resolver
enst
ENST00000316939
resolver
genesymbol
GADD45GIP1
resolver
genesymbol_syn
MRPL59
resolver
genesymbol_syn
PLINP1
resolver
genesymbol_syn
PRG6
resolver
hgnc
HGNC:29996
resolver
uniprot
Q8IVM3
resolver
uniprot
Q8TE51
resolver
uniprot
Q969P9
resolver
uniprot
Q9BSM6
resolver
uniprot_entry
G45IP_HUMAN
resolver
uniprot_sec
Q8IVM3
resolver
uniprot_sec
Q8TE51
resolver
uniprot_sec
Q969P9
resolver
uniprot_sec
Q9BSM6
resolver
amino_acid_sequence
MAASVRQARSLLGVAATLAPGSRGYRARPPPRRRPGPRWPDPEDLLTPRWQLGPRYAAKQFARYGAASGVVPGSLWPSPEQLRELEAEEREWYPSLATMQESLRVKQLAEEQKRREREQHIAECMAKMPQMIVNWQQQQRENWEKAQADKERRARLQAEAQELLGYQVDPRSARFQELLQDLEKKERKRLKEEKQKRKKEARAAALAAAVAQDPAASGAPSS
uniprot
proteins
function
FUNCTION: Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but also occur in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.
uniprot
proteins
mass_dalton
25384
uniprot
proteins
protein_family
Mitochondrion-specific ribosomal protein mL64 family
uniprot
proteins
pubmed
10441517
uniprot
proteins
pubmed
12482659
uniprot
proteins
pubmed
12716909
uniprot
proteins
pubmed
15459248
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19369195
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
22453275
uniprot
proteins
pubmed
23908630
uniprot
proteins
pubmed
25278503
uniprot
proteins
pubmed
25838379
uniprot
proteins
pubmed
25944712
uniprot
proteins
pubmed
27023846
uniprot
proteins
pubmed
28892042
uniprot
proteins
pubmed
35177605
uniprot
proteins
sequence_length
222
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:22453275, ECO:0000269|PubMed:25278503, ECO:0000269|PubMed:25838379, ECO:0000269|PubMed:28892042}. Nucleus {ECO:0000269|PubMed:12482659}. Note=Using N-terminally tagged constructs, has been found in the nucleus (PubMed:12482659). C-terminally tagged constructs are targeted exclusively to mitochondria (PubMed:22453275). This discrepancy may be explained by masking of a potential N-terminal mitochondrial targeting signal by the tag (PubMed:22453275). {ECO:0000269|PubMed:12482659, ECO:0000269|PubMed:22453275}.
uniprot
proteins