Anapc5
entrez
59008
canonical
uniprot
Q8BTZ4
canonical
ensembl
ENSMUSG00000029472
resolver
ensp
ENSMUSP00000083393
resolver
ensp
ENSMUSP00000142341
resolver
ensp
ENSMUSP00000142429
resolver
ensp
ENSMUSP00000142579
resolver
ensp
ENSMUSP00000142922
resolver
ensp
ENSMUSP00000143053
resolver
ensp
ENSMUSP00000209505
resolver
ensp
ENSMUSP00000209508
resolver
enst
ENSMUST00000196640
resolver
enst
ENSMUST00000197074
resolver
enst
ENSMUST00000197719
resolver
enst
ENSMUST00000199406
resolver
genesymbol
Anapc5
resolver
uniprot
A0A0G2JDE8
resolver
uniprot
A0A0G2JDM7
resolver
uniprot
A0A0G2JE03
resolver
uniprot
A0A0G2JF75
resolver
uniprot
Q3TGA7
resolver
uniprot
Q3TWF7
resolver
uniprot
Q3U5Y4
resolver
uniprot
Q3U981
resolver
uniprot
Q3UFC2
resolver
uniprot
Q80UJ6
resolver
uniprot
Q80W43
resolver
uniprot
Q8BWW7
resolver
uniprot
Q8C0F7
resolver
uniprot
Q9CRX0
resolver
uniprot
Q9CSL1
resolver
uniprot
Q9JJB8
resolver
uniprot_entry
A0A0G2JDE8_MOUSE
resolver
uniprot_entry
A0A0G2JDM7_MOUSE
resolver
uniprot_entry
A0A0G2JE03_MOUSE
resolver
uniprot_entry
A0A0G2JF75_MOUSE
resolver
uniprot_entry
APC5_MOUSE
resolver
uniprot_entry
Q3TWF7_MOUSE
resolver
uniprot_entry
Q3U5Y4_MOUSE
resolver
uniprot_entry
Q3U981_MOUSE
resolver
uniprot_entry
Q3UFC2_MOUSE
resolver
uniprot_sec
Q3TGA7
resolver
uniprot_sec
Q80UJ6
resolver
uniprot_sec
Q80W43
resolver
uniprot_sec
Q8BWW7
resolver
uniprot_sec
Q8C0F7
resolver
uniprot_sec
Q9CRX0
resolver
uniprot_sec
Q9CSL1
resolver
uniprot_sec
Q9JJB8
resolver
amino_acid_sequence
MMTNGVVHANLFGIKDWVTPYKIAVLVLLNEMGRTGEGAVSLVERRKLNQLLLPLLQGPDITLSKLYKLIEESCPQLANSVQIRIKLMAEGELKDMEQFFDDLSDSFSGTEPEVHKTSVVGLFLRHMILAYSKLSFSQVFKLYTALQQYFQNGEKKTVEDADMDREDGEKQMEKEELDVSVREEEVSCSGPLSQKQAEFFLSQQAALLKNDETKALTPASLQKELNNLLKFNPDFAEAHYLSYLNNLRVQDVFSSTHSLLHYFDRLILTGAEGKSNGEEGYGRSLRYAALNLAALHCRFGHYQQAELALQEAIRIAQESNDHVCLQHCLSWLYVLGQKRADSYVLLEHSVKKAVHFGLPYLASLGIQSLVQQRAFAGKTANKLMDALKDSDLLHWKHSLSELIDISIAQKTAIWRLYGRSTMALQQAQMLLSMNSLESLNAGVQQNNTESFAVALCHLAELHAEQGCFAAAGEVLKHLKDRFPPNSQHAQLWMLCDQKIQFDRAMNDGKFHLADSLVTGITALNGIEGVYRKAVVLQAQNQMTEAHKLLQKLLTYCQKLKNTEMVISVLLSVAELYWRSSSPTIAMPVLLEALALSKEYRLQYLASETVLNLAYAQLILGIPEQALTLLHMAIEPILADGAVLDKGRAMFLVSKCQVASAASYDPVKKAEALEAAIQNLSEAKNYFAQVDCRERIRDVAYFQARLYHALGKTQERNHCAMIFRQLHQELPAHGVPLINHL
uniprot
proteins
function
FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (By similarity). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (By similarity). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (By similarity). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (By similarity). {ECO:0000250|UniProtKB:Q9UJX4}.
uniprot
proteins
mass_dalton
83098
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:Q9UJX4}.
uniprot
proteins
protein_family
APC5 family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
740
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UJX4}. Cytoplasm, cytoskeleton, spindle {ECO:0000250|UniProtKB:Q9UJX4}.
uniprot
proteins