Kcna3
entrez
16491
canonical
uniprot
P16390
canonical
ensembl
ENSMUSG00000047959
resolver
ensp
ENSMUSP00000050680
resolver
enst
ENSMUST00000052718
resolver
genesymbol
Kcna3
resolver
uniprot
A3KMM2
resolver
uniprot_entry
KCNA3_MOUSE
resolver
uniprot_sec
A3KMM2
resolver
activity_regulation
ACTIVITY REGULATION: Activity is up-regulated by JAK2. {ECO:0000269|PubMed:25644777}.
uniprot
proteins
amino_acid_sequence
MTVVPGDHLLEPEAAGGGGGDPPQGGCGSGGGGGGCDRYEPLPPALPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASPSQDVFEAANNSTSGAPSGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPSSGFNSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV
uniprot
proteins
function
FUNCTION: Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. {ECO:0000269|PubMed:25644777, ECO:0000269|PubMed:27802162}.
uniprot
proteins
mass_dalton
58564
uniprot
proteins
post_translational_modification
PTM: N-glycosylation promotes the cell surface expression. {ECO:0000250|UniProtKB:P15384}.; PTM: Phosphorylation on Tyr-452 inhibits its channel activity. {ECO:0000250|UniProtKB:P15384}.
uniprot
proteins
protein_family
A (Shaker) (TC 1.A.1.2) subfamily
uniprot
proteins
protein_family
Kv1.3/KCNA3 sub-subfamily
uniprot
proteins
protein_family
Potassium channel family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
19773357
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2305265
uniprot
proteins
pubmed
25644777
uniprot
proteins
pubmed
27802162
uniprot
proteins
sequence_length
528
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:25644777}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 188..206; /note="Helical; Name=Segment S1"; /evidence="ECO:0000255"; TRANSMEM 248..269; /note="Helical; Name=Segment S2"; /evidence="ECO:0000255"; TRANSMEM 281..301; /note="Helical; Name=Segment S3"; /evidence="ECO:0000255"; TRANSMEM 316..334; /note="Helical; Voltage-sensor; Name=Segment S4"; /evidence="ECO:0000255"; TRANSMEM 351..370; /note="Helical; Name=Segment S5"; /evidence="ECO:0000255"; TRANSMEM 412..434; /note="Helical; Name=Segment S6"; /evidence="ECO:0000255
uniprot
proteins