CDC20
entrez
991
canonical
uniprot
Q12834
canonical
ensembl
ENSG00000117399
resolver
ensp
ENSP00000308450
resolver
ensp
ENSP00000361540
resolver
ensp
ENSP00000526734
resolver
ensp
ENSP00000526735
resolver
ensp
ENSP00000590177
resolver
ensp
ENSP00000590180
resolver
enst
ENST00000310955
resolver
enst
ENST00000372462
resolver
enst
ENST00000856675
resolver
enst
ENST00000856676
resolver
enst
ENST00000920118
resolver
enst
ENST00000920121
resolver
genesymbol
CDC20
resolver
hgnc
HGNC:1723
resolver
uniprot
B2R6Z6
resolver
uniprot
D3DPJ1
resolver
uniprot
Q5JUY4
resolver
uniprot
Q9BW56
resolver
uniprot
Q9UQI9
resolver
uniprot_entry
CDC20_HUMAN
resolver
uniprot_sec
B2R6Z6
resolver
uniprot_sec
D3DPJ1
resolver
uniprot_sec
Q5JUY4
resolver
uniprot_sec
Q9BW56
resolver
uniprot_sec
Q9UQI9
resolver
amino_acid_sequence
MAQFAFESDLHSLLQLDAPIPNAPPARWQRKAKEAAGPAPSPMRAANRSHSAGRTPGRTPGKSSSKVQTTPSKPGGDRYIPHRSAAQMEVASFLLSKENQPENSQTPTKKEHQKAWALNLNGFDVEEAKILRLSGKPQNAPEGYQNRLKVLYSQKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSGNVLAVALDNSVYLWSASSGDILQLLQMEQPGEYISSVAWIKEGNYLAVGTSSAEVQLWDVQQQKRLRNMTSHSARVGSLSWNSYILSSGSRSGHIHHHDVRVAEHHVATLSGHSQEVCGLRWAPDGRHLASGGNDNLVNVWPSAPGEGGWVPLQTFTQHQGAVKAVAWCPWQSNVLATGGGTSDRHIRIWNVCSGACLSAVDAHSQVCSILWSPHYKELISGHGFAQNQLVIWKYPTMAKVAELKGHTSRVLSLTMSPDGATVASAAADETLRLWRCFELDPARRREREKASAAKSSLIHQGIR
uniprot
proteins
disease_involvement
DISEASE: Oocyte/zygote/embryo maturation arrest 14 (OZEMA14) [MIM:620276]: An autosomal recessive female infertility disorder characterized by oocyte maturation arrest, fertilization failure, and/or early embryonic arrest. {ECO:0000269|PubMed:32666501, ECO:0000269|PubMed:33683667, ECO:0000269|PubMed:33898437, ECO:0000269|PubMed:34218387}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Substrate-specific adapter and activator of the anaphase promoting complex/cyclosome (APC/C) that confers substrate specificity by binding to substrates and targeting them to the APC/C for ubiquitination and degradation (PubMed:9734353, PubMed:27030811, PubMed:29343641, PubMed:27120157, PubMed:27509861). Essential for activating APC/C in the metaphase/anaphase transition of the cell cycle, targeting the degradation of cyclin B and securin (PubMed:27120157, PubMed:27509861, PubMed:32666501). Recognizes and binds the destruction box (D box), KEB box and ABBA motifs on protein substrates (PubMed:29343641, PubMed:27509861). The CDC20-APC/C complex positively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons (By similarity). CDC20-APC/C-induced degradation of NEUROD2 induces presynaptic differentiation (By similarity). The CDC20-APC/C complex promotes proper dilation formation and radial migration by degrading CCDC41 (By similarity). Component of the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation until all chromosomes are properly attached to the mitotic spindle (PubMed:27509861). The MCC, which consists of CDC20, MAD2L1/MAD2, BUB1B/BUBR1 and BUB3, is a key player of the spindle assembly checkpoint (PubMed:27509861). The MCC-bound APC/C complex is inactive and this delays the metaphase/anaphase transition (PubMed:9811605, PubMed:9637688, PubMed:27509861). When the spindle assembly checkpoint is silenced, the MCC-APC/C complex recruits the E2 enzyme UBCH10 and triggers the auto-ubiquitination of CDC20 in the MCC, thereby reactivating APC/C for transition into anaphase (PubMed:27509861). {ECO:0000250|UniProtKB:Q9JJ66, ECO:0000269|PubMed:27030811, ECO:0000269|PubMed:27120157, ECO:0000269|PubMed:27509861, ECO:0000269|PubMed:29343641, ECO:0000269|PubMed:32666501, ECO:0000269|PubMed:9637688, ECO:0000269|PubMed:9734353, ECO:0000269|PubMed:9811605}.
uniprot
proteins
mass_dalton
54723
uniprot
proteins
mutagenesis
MUTAGEN 41; /note="S->A: Loss of BUB1-mediated phosphorylation and inhibition and partially defective spindle-assembly checkpoint; when associated with A-72; A-92; A-153; A-157 and A-161."; /evidence="ECO:0000269|PubMed:15525512"; MUTAGEN 72; /note="S->A: Loss of BUB1-mediated phosphorylation and inhibition and partially defective spindle-assembly checkpoint; when associated with A-41; A-92; A-153; A-157 and A-161."; /evidence="ECO:0000269|PubMed:15525512"; MUTAGEN 92; /note="S->A: Loss of BUB1-mediated phosphorylation and inhibition and partially defective spindle-assembly checkpoint; when associated with A-41; A-72; A-153; A-157 and A-161."; /evidence="ECO:0000269|PubMed:15525512"; MUTAGEN 132; /note="R->A: Loss of interaction with MAD2L1."; /evidence="ECO:0000269|PubMed:19098431"; MUTAGEN 153; /note="S->A: Loss of BUB1-mediated phosphorylation and inhibition and partially defective spindle-assembly checkpoint; when associated with A-42; A-72; A-92; A-157 and A-161."; /evidence="ECO:0000269|PubMed:15525512"; MUTAGEN 157; /note="T->A: Loss of BUB1-mediated phosphorylation and inhibition and partially defective spindle-assembly checkpoint; when associated with A-42; A-72; A-92; A-153 and A-161."; /evidence="ECO:0000269|PubMed:15525512"; MUTAGEN 161; /note="S->A: Loss of BUB1-mediated phosphorylation and inhibition and partially defective spindle-assembly checkpoint; when associated with A-72; A-92; A-153; A-157 and A-161."; /evidence="ECO:0000269|PubMed:15525512"; MUTAGEN 485; /note="K->R: Does not affect its ability to bind the APC/C complex; when associated with R-490."; /evidence="ECO:0000269|PubMed:21926987"; MUTAGEN 490; /note="K->R: Does not affect its ability to bind the APC/C complex; when associated with R-485."; /evidence="ECO:0000269|PubMed:21926987
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000269|PubMed:29343641}.
uniprot
proteins
post_translational_modification
PTM: Acetylated (PubMed:22014574). Deacetylated at Lys-66 by SIRT2; deacetylation enhances the interaction of CDC20 with CDC27, leading to activation of anaphase promoting complex/cyclosome (APC/C) (PubMed:22014574). {ECO:0000269|PubMed:22014574}.; PTM: Phosphorylated during mitosis (PubMed:14657031). Phosphorylated by BUB1 at Ser-41; Ser-72; Ser-92; Ser-153; Thr-157 and Ser-161 (PubMed:15525512). Phosphorylated by NEK2 (PubMed:20034488). {ECO:0000269|PubMed:14657031, ECO:0000269|PubMed:15525512, ECO:0000269|PubMed:20034488}.; PTM: Dephosphorylated by CTDP1 (PubMed:22692537). {ECO:0000269|PubMed:22692537}.; PTM: Ubiquitinated and degraded by the proteasome during spindle assembly checkpoint (PubMed:18997788, PubMed:19098431). Deubiquitinated by USP44, leading to stabilization of the MAD2L1-CDC20-APC/C ternary complex, thereby preventing premature activation of the APC/C (PubMed:17443180). Ubiquitinated at Lys-490 during prometaphase (PubMed:21926987). Ubiquitination at Lys-485 and Lys-490 has no effect on its ability to bind the APC/C complex (PubMed:21926987). Ubiquitinated by UBR5 when not assembled in a multiprotein complex, leading to its degradation: UBR5 recognizes and binds a degron that is not accessible when CDC20 is part of a complex (PubMed:35217622, PubMed:37478862). {ECO:0000269|PubMed:17443180, ECO:0000269|PubMed:18997788, ECO:0000269|PubMed:19098431, ECO:0000269|PubMed:21926987, ECO:0000269|PubMed:35217622, ECO:0000269|PubMed:37478862}.
uniprot
proteins
protein_family
WD repeat CDC20/Fizzy family
uniprot
proteins
pubmed
10459014
uniprot
proteins
pubmed
11459826
uniprot
proteins
pubmed
14657031
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15525512
uniprot
proteins
pubmed
15824138
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
17403670
uniprot
proteins
pubmed
17443180
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
18794143
uniprot
proteins
pubmed
18997788
uniprot
proteins
pubmed
19098431
uniprot
proteins
pubmed
19282672
uniprot
proteins
pubmed
20034488
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
21926987
uniprot
proteins
pubmed
22014574
uniprot
proteins
pubmed
22692537
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
27030811
uniprot
proteins
pubmed
27120157
uniprot
proteins
pubmed
27509861
uniprot
proteins
pubmed
27653696
uniprot
proteins
pubmed
29162720
uniprot
proteins
pubmed
29343641
uniprot
proteins
pubmed
32666501
uniprot
proteins
pubmed
33094908
uniprot
proteins
pubmed
33683667
uniprot
proteins
pubmed
33898437
uniprot
proteins
pubmed
34218387
uniprot
proteins
pubmed
35217622
uniprot
proteins
pubmed
37478862
uniprot
proteins
pubmed
7513050
uniprot
proteins
pubmed
9637688
uniprot
proteins
pubmed
9734353
uniprot
proteins
pubmed
9811605
uniprot
proteins
sequence_length
499
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20034488}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:32666501, ECO:0000269|PubMed:33094908}. Cytoplasm, cytoskeleton, spindle pole {ECO:0000269|PubMed:20034488}.
uniprot
proteins