Q9Z1A5
uniprot
Q9Z1A5
canonical
activity_regulation
ACTIVITY REGULATION: Binding of TP53BP2 to the regulatory subunit NAE1 decreases neddylation activity. {ECO:0000250}.
uniprot
proteins
amino_acid_sequence
MAQQGKILKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTIIDGNQVSGEDVGNNFFLQKCSIGKNRAQAAMEFLQELNSDVSGSFVEESPENLLDNDPSFFCRFTIVVATQLLESTLLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNALEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKSYKEKEDFRELIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITKQTPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSNKYIKLQNVYREKAKKDAAAVGNHVAKLLQSCGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLHTVNKDEIISSMDNPDNEIVLYLMLRAVDRFHKQHGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYVHEFCRYGAAEPHTVAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL
uniprot
proteins
function
FUNCTION: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation (PubMed:14557245). The covalent attachment of NEDD8 to target proteins is known as 'neddylation' and the process is involved in the regulation of cell growth, viability and development. {ECO:0000250|UniProtKB:Q13564, ECO:0000269|PubMed:14557245}.
uniprot
proteins
mass_dalton
60383
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein neddylation.
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by TRIP12, leading to its degradation by the proteasome. {ECO:0000250}.
uniprot
proteins
protein_family
ULA1 subfamily
uniprot
proteins
protein_family
Ubiquitin-activating E1 family
uniprot
proteins
pubmed
14557245
uniprot
proteins
pubmed
8626687
uniprot
proteins
sequence_length
534
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:14557245}. Note=Colocalizes with APP in lipid rafts.
uniprot
proteins