C6
entrez
729
canonical
uniprot
P13671
canonical
ensembl
ENSG00000039537
resolver
ensp
ENSP00000263413
resolver
ensp
ENSP00000338861
resolver
ensp
ENSP00000575309
resolver
ensp
ENSP00000575311
resolver
ensp
ENSP00000575313
resolver
ensp
ENSP00000575316
resolver
ensp
ENSP00000575318
resolver
ensp
ENSP00000575320
resolver
ensp
ENSP00000575322
resolver
ensp
ENSP00000575326
resolver
ensp
ENSP00000575328
resolver
ensp
ENSP00000575329
resolver
ensp
ENSP00000575330
resolver
ensp
ENSP00000575331
resolver
ensp
ENSP00000575332
resolver
ensp
ENSP00000575333
resolver
ensp
ENSP00000575334
resolver
ensp
ENSP00000575335
resolver
ensp
ENSP00000575336
resolver
ensp
ENSP00000575337
resolver
ensp
ENSP00000575341
resolver
ensp
ENSP00000612896
resolver
ensp
ENSP00000612897
resolver
ensp
ENSP00000612899
resolver
ensp
ENSP00000612901
resolver
enst
ENST00000263413
resolver
enst
ENST00000337836
resolver
enst
ENST00000905252
resolver
enst
ENST00000905254
resolver
enst
ENST00000905257
resolver
enst
ENST00000905259
resolver
enst
ENST00000905261
resolver
enst
ENST00000905267
resolver
enst
ENST00000905269
resolver
enst
ENST00000905271
resolver
enst
ENST00000905272
resolver
enst
ENST00000905273
resolver
enst
ENST00000905274
resolver
enst
ENST00000905275
resolver
enst
ENST00000905276
resolver
enst
ENST00000905277
resolver
enst
ENST00000905278
resolver
enst
ENST00000905282
resolver
enst
ENST00000942837
resolver
enst
ENST00000942838
resolver
enst
ENST00000942842
resolver
genesymbol
C6
resolver
hgnc
HGNC:1339
resolver
uniprot_entry
CO6_HUMAN
resolver
activity_regulation
ACTIVITY REGULATION: Membrane attack complex (MAC) assembly is inhibited by CD59, thereby protecting self-cells from damage during complement activation (PubMed:36797260). MAC assembly is also inhibited by clusterin (CLU) chaperones that inhibit polymerization of C9 (PubMed:34667172). {ECO:0000269|PubMed:34667172, ECO:0000269|PubMed:36797260}.
uniprot
proteins
amino_acid_sequence
MARRSVLYFILLNALINKGQACFCDHYAWTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQETRECNWQRCPINCLLGDFGPWSDCDPCIEKQSKVRSVLRPSQFGGQPCTAPLVAFQPCIPSKLCKIEEADCKNKFRCDSGRCIARKLECNGENDCGDNSDERDCGRTKAVCTRKYNPIPSVQLMGNGFHFLAGEPRGEVLDNSFTGGICKTVKSSRTSNPYRVPANLENVGFEVQTAEDDLKTDFYKDLTSLGHNENQQGSFSSQGGSSFSVPIFYSSKRSENINHNSAFKQAIQASHKKDSSFIRIHKVMKVLNFTTKAKDLHLSDVFLKALNHLPLEYNSALYSRIFDDFGTHYFTSGSLGGVYDLLYQFSSEELKNSGLTEEEAKHCVRIETKKRVLFAKKTKVEHRCTTNKLSEKHEGSFIQGAEKSISLIRGGRSEYGAALAWEKGSSGLEEKTFSEWLESVKENPAVIDFELAPIVDLVRNIPCAVTKRNNLRKALQEYAAKFDPCQCAPCPNNGRPTLSGTECLCVCQSGTYGENCEKQSPDYKSNAVDGQWGCWSSWSTCDATYKRSRTRECNNPAPQRGGKRCEGEKRQEEDCTFSIMENNGQPCINDDEEMKEVDLPEIEADSGCPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQGNSWTPPISNSLTCEKDTLTKLKGHCQLGQKQSGSECICMSPEEDCSHHSEDLCVFDTDSNDYFTSPACKFLAEKCLNNQQLHFLHIGSCQDGRQLEWGLERTRLSSNSTKKESCGYDTCYDWEKCSASTSKCVCLLPPQCFKGGNQLYCVKMGSSTSEKTLNICEVGTIRCANRKMEILHPGKCLA
uniprot
proteins
disease_involvement
DISEASE: Complement component 6 deficiency (C6D) [MIM:612446]: A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. {ECO:0000269|PubMed:15565285}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Component of the membrane attack complex (MAC), a multiprotein complex activated by the complement cascade, which inserts into a target cell membrane and forms a pore, leading to target cell membrane rupture and cell lysis (PubMed:22267737, PubMed:22832194, PubMed:26841837, PubMed:27052168, PubMed:30552328). The MAC is initiated by proteolytic cleavage of C5 into complement C5b in response to the classical, alternative, lectin and GZMK complement pathways (PubMed:30552328, PubMed:39914456, PubMed:39814882). The complement pathways consist in a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:30552328). Together with component C5b, involved in MAC complex assembly: complement C5b and C6 associate with the outer leaflet of target cell membrane, reducing the energy for membrane bending (PubMed:30552328, PubMed:32569291). {ECO:0000269|PubMed:22267737, ECO:0000269|PubMed:22832194, ECO:0000269|PubMed:26841837, ECO:0000269|PubMed:27052168, ECO:0000269|PubMed:30552328, ECO:0000269|PubMed:32569291, ECO:0000269|PubMed:39814882, ECO:0000269|PubMed:39914456}.
uniprot
proteins
mass_dalton
104786
uniprot
proteins
post_translational_modification
PTM: All cysteine residues are assumed to be cross-linked to one another. Individual modules containing an even number of conserved cysteine residues are supposed to have disulfide linkages only within the same module. {ECO:0000269|PubMed:9366265}.
uniprot
proteins
protein_family
Complement C6/C7/C8/C9 family
uniprot
proteins
pubmed
10551839
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15565285
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
22267737
uniprot
proteins
pubmed
22500023
uniprot
proteins
pubmed
22832194
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
2468158
uniprot
proteins
pubmed
26841837
uniprot
proteins
pubmed
27052168
uniprot
proteins
pubmed
2789218
uniprot
proteins
pubmed
2808363
uniprot
proteins
pubmed
30552328
uniprot
proteins
pubmed
31061395
uniprot
proteins
pubmed
32569291
uniprot
proteins
pubmed
34667172
uniprot
proteins
pubmed
36797260
uniprot
proteins
pubmed
39814882
uniprot
proteins
pubmed
39914456
uniprot
proteins
pubmed
8101442
uniprot
proteins
pubmed
8512929
uniprot
proteins
pubmed
9366265
uniprot
proteins
sequence_length
934
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:2808363}. Target cell membrane {ECO:0000269|PubMed:30552328, ECO:0000269|PubMed:31061395, ECO:0000269|PubMed:32569291}; Multi-pass membrane protein {ECO:0000269|PubMed:30552328}. Note=Secreted as soluble protein (PubMed:2808363). Inserts into the cell membrane of target cells (PubMed:30552328, PubMed:31061395). {ECO:0000269|PubMed:2808363, ECO:0000269|PubMed:30552328, ECO:0000269|PubMed:31061395}.
uniprot
proteins
transmembrane_region
TRANSMEM 278..290; /note="Beta stranded"; /evidence="ECO:0000269|PubMed:30552328, ECO:0007744|PDB:6H04"; TRANSMEM 402..415; /note="Beta stranded"; /evidence="ECO:0000269|PubMed:30552328, ECO:0007744|PDB:6H04
uniprot
proteins