Pcsk1n
entrez
30052
canonical
uniprot
Q9QXV0
canonical
ensembl
ENSMUSG00000039278
resolver
ensp
ENSMUSP00000040342
resolver
enst
ENSMUST00000041096
resolver
genesymbol
Pcsk1n
resolver
uniprot
Q91W26
resolver
uniprot_entry
PCS1N_MOUSE
resolver
uniprot_sec
Q91W26
resolver
amino_acid_sequence
MAGSPLLCGPRAGGVGILVLLLLGLLRLPPTLSARPVKEPRSLSAASAPLVETSTPLRLRRAVPRGEAAGAVQELARALAHLLEAERQERARAEAQEAEDQQARVLAQLLRAWGSPRASDPPLAPDDDPDAPAAQLARALLRARLDPAALAAQLVPAPAAAPRPRPPVYDDGPTGPDVEDAGDETPDVDPELLRYLLGRILTGSSEPEAAPAPRRLRRSVDQDLGPEVPPENVLGALLRVKRLENPSPQAPARRLLPP
uniprot
proteins
function
FUNCTION: May act as a protein chaperone that prevents the aggregation of client proteins and plays a role in neuroprotection (PubMed:24042052, PubMed:24102330, PubMed:27457957, PubMed:32607937, PubMed:35549000, PubMed:35527562). Blocks the trans-synaptic spread of SNCA/alpha-synuclein in the brain (PubMed:35527562). May form spheres that encapsulate client proteins (PubMed:35549000). May prevent aggregation of amyloid beta and SNCA/alpha-synuclein (PubMed:24102330, PubMed:27457957). Cannot disaggregate preformed fibrils (PubMed:27457957). Additionally, may regulate the neuroendocrine secretory pathway by acting as a specific endogenous inhibitor of PCSK1 (PubMed:10632593, PubMed:11742530, PubMed:11719503). ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, reduce the activity of the 87 kDa form of PCSK1, but not the autocatalytically derived 66 kDa form, in the endoplasmic reticulum and Golgi (PubMed:11742530, PubMed:11719503). May control the intracellular timing of PCSK1 rather than its total level of activity and slows down convertase-mediated processing of proopiomelanocortin and proenkephalin (PubMed:10632593, PubMed:11719503). {ECO:0000269|PubMed:10632593, ECO:0000269|PubMed:11719503, ECO:0000269|PubMed:11742530, ECO:0000269|PubMed:24042052, ECO:0000269|PubMed:24102330, ECO:0000269|PubMed:27457957, ECO:0000269|PubMed:32607937, ECO:0000269|PubMed:35527562, ECO:0000269|PubMed:35549000}.; FUNCTION: [Big LEN]: Endogenous ligand for GPR171 (PubMed:24043826). Neuropeptide involved in the regulation of feeding (PubMed:24043826). {ECO:0000269|PubMed:24043826}.; FUNCTION: [PEN]: Endogenous ligand for GPR83. Neuropeptide involved in the regulation of feeding. {ECO:0000269|PubMed:27117253}.
uniprot
proteins
mass_dalton
27270
uniprot
proteins
mutagenesis
MUTAGEN 241..242; /note="KR->SS: Abolishes inhibition of PCSK1."; /evidence="ECO:0000269|PubMed:11719503
uniprot
proteins
post_translational_modification
PTM: Proteolytically cleaved in the Golgi. Little SAAS, PEN, PEN-20 and Big LEN are the major processed peptides in proSAAS-overexpressing AtT-20 pituitary corticotropic cell line. {ECO:0000269|PubMed:10632593, ECO:0000269|PubMed:11094058, ECO:0000269|PubMed:11259501, ECO:0000269|PubMed:11719503, ECO:0000269|PubMed:11742530}.
uniprot
proteins
pubmed
10632593
uniprot
proteins
pubmed
11094058
uniprot
proteins
pubmed
11259501
uniprot
proteins
pubmed
11719503
uniprot
proteins
pubmed
11742530
uniprot
proteins
pubmed
15018810
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16631141
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
24042052
uniprot
proteins
pubmed
24043826
uniprot
proteins
pubmed
24102330
uniprot
proteins
pubmed
27117253
uniprot
proteins
pubmed
27457957
uniprot
proteins
pubmed
32607937
uniprot
proteins
pubmed
32691307
uniprot
proteins
pubmed
35527562
uniprot
proteins
pubmed
35549000
uniprot
proteins
pubmed
9630436
uniprot
proteins
pubmed
9756897
uniprot
proteins
sequence_length
258
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10632593, ECO:0000269|PubMed:11742530}. Golgi apparatus, trans-Golgi network {ECO:0000269|PubMed:11742530, ECO:0000269|PubMed:35549000}. Note=Proteotoxic stress stimulates its intracellular retention. {ECO:0000269|PubMed:32607937}.
uniprot
proteins