Rufy1
entrez
216724
canonical
uniprot
Q8BIJ7
canonical
ensembl
ENSMUSG00000020375
resolver
ensp
ENSMUSP00000020643
resolver
ensp
ENSMUSP00000210248
resolver
enst
ENSMUST00000020643
resolver
genesymbol
Rufy1
resolver
genesymbol_syn
Rabip4
resolver
uniprot
Q8BKQ4
resolver
uniprot
Q8BL21
resolver
uniprot
Q9EPM6
resolver
uniprot_entry
RUFY1_MOUSE
resolver
uniprot_sec
Q8BKQ4
resolver
uniprot_sec
Q8BL21
resolver
uniprot_sec
Q9EPM6
resolver
amino_acid_sequence
MAARGECRRAGQDSEPEPEREPESEPGPEPEPQAGLESGEAFEIVDRSQLPSPGELRSASRPRVADSWSAPILTLARRATGNLSASCGSALRAAAGLGDGGGGGERAASKGQMMEERANLMHMMKLSIKVLLQSALSLGRSLDADYAPLQQFFVVMEHCLKHGLKVKKSFIGQNKSFFGPLELVEKLCPEASDIATSVRNLPELKTAVGRGRAWLYLALMQKKLADYLKVLIDNKQLLSEFYEPEALMMEEEGMVIVGLLVGLNVLDANLCLKGEDLDSQVGVIDFSLCLKDAQDLDSGREHERITDVLDQKNYVEELNRHLSCTVGDLQTKIDGLEKTNSKLQEELSAATDRICSLQKEQQQLREQNEVIRERSEKSVEITKQDTKVELETYKQTRQGLDEMYSDVWKQLKEEKKVRLELEKELELQIGMKTEMEIAMKLLEKDTHEKQDTLVALRQQLEEVKAINLQMFHKVQSAESSLQQKNEAIASFEGKTTQVMSSMKQMEERLQQAERARQAAEERSHKLQQELSGRGSALQLQLSQLRDQCSGLEKELKSEKEQRQALQRELQREKDTSCLLQTELQQVEGLKKELRELQDEKAELRKVCEEQEQALQEMGLHLSQSKLKMEDIKEVNKALKGHTWLKDDEATHCKQCEKDFSISRRKHHCRNCGHIFCNTCSSNELALPSYPKPVRVCDSCHTLLLQRCSSTAS
uniprot
proteins
function
FUNCTION: Activating adapter involved in cargo sorting from early/recycling endosomes (PubMed:11172003, PubMed:16522682). Regulates retrieval of proteins from endosomes to the trans-Golgi network through interaction with the dynein-dynactin complex. Dual effector of RAB4B and RAB14, mediates a cooperative interaction allowing endosomal tethering and fusion (By similarity). Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in early endosomal trafficking (PubMed:11509568). In oocytes, self-assembles to form a protein matrix which hold together endolysosomes, autophagosomes and proteasomes and generate non-membrane-bound compartments called endo-lysosomal vesicular assemblies (ELVAs). In immature oocytes, ELVAs sequester ubiquitinated protein aggregates and degrade them upon oocyte maturation (PubMed:38382525). {ECO:0000250|UniProtKB:Q96T51, ECO:0000269|PubMed:11172003, ECO:0000269|PubMed:11509568, ECO:0000269|PubMed:16522682, ECO:0000269|PubMed:38382525}.
uniprot
proteins
mass_dalton
80376
uniprot
proteins
post_translational_modification
PTM: Phosphorylation on Tyr-393 and/or Tyr-404 is required for interaction with BMX and endosomal targeting. {ECO:0000250|UniProtKB:Q96T51}.
uniprot
proteins
pubmed
11172003
uniprot
proteins
pubmed
11509568
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16522682
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
38382525
uniprot
proteins
sequence_length
712
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Early endosome membrane {ECO:0000269|PubMed:11172003, ECO:0000269|PubMed:11509568, ECO:0000269|PubMed:16522682}; Peripheral membrane protein {ECO:0000269|PubMed:11172003, ECO:0000269|PubMed:11509568, ECO:0000269|PubMed:16522682}. Note=In oocytes, localizes in non-membrane-bound compartments called endo-lysosomal vesicular assemblies (ELVAs). {ECO:0000269|PubMed:38382525}.
uniprot
proteins