ARPIN
entrez
348110
canonical
uniprot
Q7Z6K5
canonical
ensembl
ENSG00000242498
resolver
ensembl
ENSG00000250021
resolver
ensp
ENSP00000350075
resolver
ensp
ENSP00000453687
resolver
enst
ENST00000460685
resolver
genesymbol
ARPIN
resolver
genesymbol_syn
C15orf38
resolver
hgnc
HGNC:28782
resolver
uniprot
E2QRD5
resolver
uniprot
H0YMP5
resolver
uniprot_entry
ARPIN_HUMAN
resolver
uniprot_entry
H0YMP5_HUMAN
resolver
uniprot_sec
E2QRD5
resolver
amino_acid_sequence
MSRIYHDGALRNKAVQSVRLPGAWDPAAHQGGNGVLLEGELIDVSRHSILDTHGRKERYYVLYIRPSHIHRRKFDAKGNEIEPNFSATRKVNTGFLMSSYKVEAKGDTDRLTPEALKGLVNKPELLALTESLTPDHTVAFWMPESEMEVMELELGAGVRLKTRGDGPFLDSLAKLEAGTVTKCNFTGDGKTGASWTDNIMAQKCSKGAAAEIREQGDGAEDEEWDD
uniprot
proteins
function
FUNCTION: Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence. {ECO:0000269|PubMed:24132237}.
uniprot
proteins
mass_dalton
24943
uniprot
proteins
protein_family
Arpin family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
pubmed
24132237
uniprot
proteins
sequence_length
226
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell projection, lamellipodium {ECO:0000250}. Note=Colocalized with the WAVE complex at lamelliupodium tip. {ECO:0000250}.
uniprot
proteins