CNOT8
entrez
9337
canonical
uniprot
Q9UFF9
canonical
ensembl
ENSG00000155508
resolver
ensp
ENSP00000285896
resolver
ensp
ENSP00000384747
resolver
ensp
ENSP00000428305
resolver
ensp
ENSP00000428565
resolver
ensp
ENSP00000428576
resolver
ensp
ENSP00000429394
resolver
ensp
ENSP00000429576
resolver
ensp
ENSP00000429882
resolver
ensp
ENSP00000430833
resolver
ensp
ENSP00000431034
resolver
ensp
ENSP00000543189
resolver
ensp
ENSP00000543193
resolver
ensp
ENSP00000543199
resolver
ensp
ENSP00000543200
resolver
ensp
ENSP00000543203
resolver
ensp
ENSP00000543204
resolver
ensp
ENSP00000543206
resolver
ensp
ENSP00000543207
resolver
ensp
ENSP00000543212
resolver
ensp
ENSP00000627229
resolver
enst
ENST00000522644
resolver
enst
ENST00000524105
resolver
genesymbol
CNOT8
resolver
genesymbol_syn
CALIF
resolver
genesymbol_syn
POP2
resolver
hgnc
HGNC:9207
resolver
uniprot
B0AZS3
resolver
uniprot
B2RAR8
resolver
uniprot
B7Z8R1
resolver
uniprot
B7Z9U0
resolver
uniprot
D3DQI8
resolver
uniprot
E5RHL9
resolver
uniprot
F6W293
resolver
uniprot
O95709
resolver
uniprot
Q7Z521
resolver
uniprot
Q9H6Y1
resolver
uniprot_entry
B7Z9U0_HUMAN
resolver
uniprot_entry
CNOT8_HUMAN
resolver
uniprot_entry
E5RHL9_HUMAN
resolver
uniprot_entry
F6W293_HUMAN
resolver
uniprot_sec
B0AZS3
resolver
uniprot_sec
B2RAR8
resolver
uniprot_sec
B7Z8R1
resolver
uniprot_sec
D3DQI8
resolver
uniprot_sec
O95709
resolver
uniprot_sec
Q7Z521
resolver
uniprot_sec
Q9H6Y1
resolver
amino_acid_sequence
MPAALVENSQVICEVWASNLEEEMRKIREIVLSYSYIAMDTEFPGVVVRPIGEFRSSIDYQYQLLRCNVDLLKIIQLGLTFTNEKGEYPSGINTWQFNFKFNLTEDMYSQDSIDLLANSGLQFQKHEEEGIDTLHFAELLMTSGVVLCDNVKWLSFHSGYDFGYMVKLLTDSRLPEEEHEFFHILNLFFPSIYDVKYLMKSCKNLKGGLQEVADQLDLQRIGRQHQAGSDSLLTGMAFFRMKELFFEDSIDDAKYCGRLYGLGTGVAQKQNEDVDSAQEKMSILAIINNMQQ
uniprot
proteins
ec_number
3.1.13.4
uniprot
proteins
function
FUNCTION: Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex also seems to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity. {ECO:0000269|PubMed:12771185, ECO:0000269|PubMed:19605561, ECO:0000269|PubMed:20065043, ECO:0000269|PubMed:23236473}.
uniprot
proteins
mass_dalton
33540
uniprot
proteins
mutagenesis
MUTAGEN 40; /note="D->A: Impairs deadenylation and decay of mRNAi-targeted mRNA; when associated with A-42."; /evidence="ECO:0000269|PubMed:20065043"; MUTAGEN 42; /note="E->A: Impairs deadenylation and decay of mRNAi-targeted mRNA; when associated with A-40."; /evidence="ECO:0000269|PubMed:20065043
uniprot
proteins
protein_family
CAF1 family
uniprot
proteins
pubmed
10036195
uniprot
proteins
pubmed
10637334
uniprot
proteins
pubmed
11136725
uniprot
proteins
pubmed
11230166
uniprot
proteins
pubmed
12771185
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15372022
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15769875
uniprot
proteins
pubmed
19558367
uniprot
proteins
pubmed
19605561
uniprot
proteins
pubmed
20065043
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23236473
uniprot
proteins
sequence_length
292
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12771185}. Nucleus {ECO:0000269|PubMed:12771185}.
uniprot
proteins