TSSK6
entrez
83983
canonical
uniprot
Q9BXA6
canonical
ensembl
ENSG00000178093
resolver
ensp
ENSP00000466056
resolver
ensp
ENSP00000466477
resolver
enst
ENST00000585580
resolver
enst
ENST00000587522
resolver
genesymbol
TSSK6
resolver
genesymbol_syn
SSTK
resolver
hgnc
HGNC:30410
resolver
uniprot
A0A024R7Q5
resolver
uniprot
B2R9F8
resolver
uniprot
Q6ZMC4
resolver
uniprot
Q96LJ4
resolver
uniprot_entry
A0A024R7Q5_HUMAN
resolver
uniprot_entry
TSSK6_HUMAN
resolver
uniprot_sec
B2R9F8
resolver
uniprot_sec
Q6ZMC4
resolver
uniprot_sec
Q96LJ4
resolver
amino_acid_sequence
MSGDKLLSELGYKLGRTIGEGSYSKVKVATSKKYKGTVAIKVVDRRRAPPDFVNKFLPRELSILRGVRHPHIVHVFEFIEVCNGKLYIVMEAAATDLLQAVQRNGRIPGVQARDLFAQIAGAVRYLHDHHLVHRDLKCENVLLSPDERRVKLTDFGFGRQAHGYPDLSTTYCGSAAYASPEVLLGIPYDPKKYDVWSMGVVLYVMVTGCMPFDDSDIAGLPRRQKRGVLYPEGLELSERCKALIAELLQFSPSARPSAGQVARNCWLRAGDSG
uniprot
proteins
ec_number
2.7.11.1
uniprot
proteins
function
FUNCTION: Serine/threonine-protein kinase component of the sperm flagellar doublet microtubules (PubMed:15870294). May act as a regulator of sperm motility by mediating phosphorylation of sperm doublet microtubule proteins (By similarity). Plays a role in DNA condensation during postmeiotic chromatin remodeling and histone-to-protamine transition during spermatogenesis (By similarity). {ECO:0000250|UniProtKB:Q925K9, ECO:0000269|PubMed:15870294}.
uniprot
proteins
mass_dalton
30331
uniprot
proteins
mutagenesis
MUTAGEN 41; /note="K->M: Loss of kinase activity. Loss of binding to TSACC."; /evidence="ECO:0000269|PubMed:15870294, ECO:0000269|PubMed:20829357"; MUTAGEN 135; /note="D->N: Loss of kinase activity. No effect of binding to TSACC."; /evidence="ECO:0000269|PubMed:15870294, ECO:0000269|PubMed:20829357
uniprot
proteins
post_translational_modification
PTM: Autophosphorylated. {ECO:0000269|PubMed:15870294}.; PTM: Ubiquitinated; HSP90 activity negatively regulates ubiquitination and degradation. {ECO:0000250|UniProtKB:Q925K9}.
uniprot
proteins
protein_family
CAMK Ser/Thr protein kinase family
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15870294
uniprot
proteins
pubmed
20829357
uniprot
proteins
sequence_length
273
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme {ECO:0000250|UniProtKB:Q925K9}. Nucleus {ECO:0000250|UniProtKB:Q925K9}. Note=Component of the sperm flagellar doublet microtubules. Also localizes in the nucleus of elongating spermatids. {ECO:0000250|UniProtKB:Q925K9}.
uniprot
proteins