H1-6
entrez
107970
canonical
uniprot
Q07133
canonical
ensembl
ENSMUSG00000036211
resolver
ensp
ENSMUSP00000037304
resolver
enst
ENSMUST00000041052
resolver
genesymbol
H1-6
resolver
genesymbol
H1f6
resolver
genesymbol_syn
H1f6
resolver
genesymbol_syn
H1ft
resolver
genesymbol_syn
H1t
resolver
genesymbol_syn
Hist1h1t
resolver
uniprot
I7HFT9
resolver
uniprot
Q0VEA3
resolver
uniprot
Q8CGP8
resolver
uniprot_entry
H1T_MOUSE
resolver
uniprot_entry
I7HFT9_MOUSE
resolver
uniprot_sec
Q0VEA3
resolver
uniprot_sec
Q8CGP8
resolver
amino_acid_sequence
MSETAPAASSTLVPAPVEKPSSKRRGKKPGLAPARKPRGFSVSKLIPEALSTSQERAGMSLAALKKALAAAGYDVEKNNSRIKLALKRLVNKGVLVQTKGTGASGSFKLSKKAASGNDKGKGKKSASAKAKKMGLPRASRSPKSSKTKAVKKPKATPTKASGSGRKTKGAKGVQQRKSPAKARAANPNSGKAKMVMQKTDLRKAAGRK
uniprot
proteins
function
FUNCTION: Testis-specific histone H1 that forms less compacted chromatin compared to other H1 histone subtypes. Formation of more relaxed chromatin may be required to promote chromatin architecture required for proper chromosome regulation during meiosis, such as homologous recombination. Histones H1 act as linkers that bind to nucleosomes and compact polynucleosomes into a higher-order chromatin configuration. {ECO:0000250|UniProtKB:P22492}.
uniprot
proteins
mass_dalton
21540
uniprot
proteins
post_translational_modification
PTM: Deamidation of Asn-78 and Asn-79 by CTPS1 in response to DNA damage promotes subsequent acetylation of histone H1 at Lys-77 (H1K75ac). {ECO:0000250|UniProtKB:P10412}.; PTM: Acetylated at Lys-77 (H1K75ac) by EP300 following deamidation of Asn-78 and Asn-79 by CTPS1 in response to DNA damage, thereby increasing chromatin accessibility to facilitate the recruitment of DNA repair proteins. {ECO:0000250|UniProtKB:P10412}.; PTM: Phosphorylated in early spermatids. {ECO:0000269|PubMed:19043117}.; PTM: Citrullination at Arg-56 (H1R54ci) by PADI4 takes place within the DNA-binding site of H1 and results in its displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. {ECO:0000250|UniProtKB:P43275}.
uniprot
proteins
protein_family
Histone H1/H5 family
uniprot
proteins
pubmed
12408966
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18698803
uniprot
proteins
pubmed
19043117
uniprot
proteins
pubmed
8241275
uniprot
proteins
sequence_length
208
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Chromosome {ECO:0000305}.
uniprot
proteins