Sp7
entrez
170574
canonical
uniprot
Q8VI67
canonical
ensembl
ENSMUSG00000060284
resolver
ensp
ENSMUSP00000077596
resolver
ensp
ENSMUSP00000154859
resolver
ensp
ENSMUSP00000314423
resolver
enst
ENSMUST00000078508
resolver
enst
ENSMUST00000229464
resolver
genesymbol
Sp7
resolver
genesymbol_syn
Osx
resolver
uniprot
A0A2R8VH90
resolver
uniprot
Q2KHK9
resolver
uniprot
Q5RM08
resolver
uniprot
Q8C5R3
resolver
uniprot
Q8C6A7
resolver
uniprot_entry
A0A2R8VH90_MOUSE
resolver
uniprot_entry
Q2KHK9_MOUSE
resolver
uniprot_entry
Q5RM08_MOUSE
resolver
uniprot_entry
SP7_MOUSE
resolver
uniprot_sec
Q8C5R3
resolver
uniprot_sec
Q8C6A7
resolver
amino_acid_sequence
MASSLLEEEAHYGSSPLAMLTAACSKFGGSSPLRDSTTLGKGGTKKPYADLSAPKTMGDAYPAPFSSTNGLLSPAGSPPAPASGYANDYPPFPHSFPGPTGAQDPGLLVPKGHSSSDCLPSVYTSLDMTHPYGSWYKAGIHAGISPGPGNTPTPWWDMHPGGNWLGGGQGQGDGLQGTLSTGPAQPPLNPQLPTYPSDFAPLNPAPYPAPHLLQPGPQHVLPQDVYKPKAVGNSGQLEGSGAAKPPRGAGTGGSGGYAGSGAGRSTCDCPNCQELERLGAAAAGLRKKPIHSCHIPGCGKVYGKASHLKAHLRWHTGERPFVCNWLFCGKRFTRSDELERHVRTHTREKKFTCLLCSKRFTRSDHLSKHQRTHGEPGPGPPPSGPKELGEGRSVGEEEANQPPRSSTSPAPPEKAHGGSPEQSNLLEI
uniprot
proteins
function
FUNCTION: Transcriptional activator essential for osteoblast differentiation (PubMed:11792318, PubMed:17510056, PubMed:30026585). Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (PubMed:11792318, PubMed:17510056). {ECO:0000269|PubMed:11792318, ECO:0000269|PubMed:17510056, ECO:0000269|PubMed:30026585}.
uniprot
proteins
mass_dalton
44718
uniprot
proteins
mutagenesis
MUTAGEN 41..46; /note="KGGTKK->RGGTRR: Decreased propionylation."; /evidence="ECO:0000269|PubMed:30026585"; MUTAGEN 368; /note="K->R: Decreased propionylation, leading to increased transcription activator activity."; /evidence="ECO:0000269|PubMed:30026585
uniprot
proteins
post_translational_modification
PTM: Propionylated (PubMed:30026585). Depropionylation at Lys-368 by SIRT7 activates transcription factor activity and positively regulates bone formation by osteoblasts (PubMed:30026585). {ECO:0000269|PubMed:30026585}.; PTM: Ubiquitination at leads to proteasomal degradation. SP7 is a short-live protein with an endogenous half-life of approximately 12 hours (By similarity). {ECO:0000250|UniProtKB:Q8TDD2}.
uniprot
proteins
protein_family
Sp1 C2H2-type zinc-finger protein family
uniprot
proteins
pubmed
11792318
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17510056
uniprot
proteins
pubmed
19927124
uniprot
proteins
pubmed
30026585
uniprot
proteins
sequence_length
428
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11792318}.
uniprot
proteins