RNASE7
entrez
84659
canonical
uniprot
Q9H1E1
canonical
ensembl
ENSG00000165799
resolver
ensp
ENSP00000298690
resolver
ensp
ENSP00000431382
resolver
enst
ENST00000298690
resolver
enst
ENST00000481538
resolver
genesymbol
RNASE7
resolver
hgnc
HGNC:19278
resolver
uniprot
P80927
resolver
uniprot
P83685
resolver
uniprot
Q546N3
resolver
uniprot_entry
RNAS7_HUMAN
resolver
uniprot_sec
P80927
resolver
uniprot_sec
P83685
resolver
uniprot_sec
Q546N3
resolver
amino_acid_sequence
MAPARAGFCPLLLLLLLGLWVAEIPVSAKPKGMTSSQWFKIQHMQPSPQACNSAMKNINKHTKRCKDLNTFLHEPFSSVAATCQTPKIACKNGDKNCHQSHGAVSLTMCKLTSGKHPNCRYKEKRQNKSYVVACKPPQKKDSQQFHLVPVHLDRVL
uniprot
proteins
ec_number
3.1.27.-
uniprot
proteins
function
FUNCTION: Exhibits a potent RNase activity (PubMed:12244054, PubMed:12527768, PubMed:17150966). Has broad-spectrum antimicrobial activity against many pathogenic microorganisms including uropathogenic E.coli (UPEC), and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium (PubMed:12244054, PubMed:12527768, PubMed:17150966, PubMed:25075772, PubMed:33818125). Causes loss of bacterial membrane integrity (PubMed:17150966). Probably contributes to urinary tract sterility (PubMed:25075772). Bactericidal activity is independent of RNase activity (PubMed:17150966). {ECO:0000269|PubMed:12244054, ECO:0000269|PubMed:12527768, ECO:0000269|PubMed:17150966, ECO:0000269|PubMed:25075772, ECO:0000269|PubMed:33818125}.
uniprot
proteins
mass_dalton
17419
uniprot
proteins
mutagenesis
MUTAGEN 29..32; /note="Missing: Significant loss of bactericidal activity. No effect on catalytic activity."; /evidence="ECO:0000269|PubMed:17150966"; MUTAGEN 29; /note="K->A: Slight loss of bactericidal activity. No effect on catalytic activity."; /evidence="ECO:0000269|PubMed:17150966"; MUTAGEN 31; /note="K->A: Significant loss of bactericidal activity. No effect on catalytic activity."; /evidence="ECO:0000269|PubMed:17150966"; MUTAGEN 43; /note="H->A: Loss of catalytic activity. No effect on bactericidal activity."; /evidence="ECO:0000269|PubMed:17150966"; MUTAGEN 60..63; /note="KHTK->NHTQ: No significant effect on bactericidal activity or catalytic activity."; /evidence="ECO:0000269|PubMed:17150966"; MUTAGEN 66; /note="K->A: Loss of catalytic activity. No effect on bactericidal activity."; /evidence="ECO:0000269|PubMed:17150966"; MUTAGEN 124..128; /note="KRQNK->AAQNT: No significant effect on bactericidal activity or catalytic activity."; /evidence="ECO:0000269|PubMed:17150966"; MUTAGEN 139..140; /note="KK->QQ: Moderate loss of bactericidal activity. No effect on catalytic activity."; /evidence="ECO:0000269|PubMed:17150966"; MUTAGEN 151; /note="H->A: Loss of catalytic activity. No effect on bactericidal activity."; /evidence="ECO:0000269|PubMed:17150966
uniprot
proteins
protein_family
Pancreatic ribonuclease family
uniprot
proteins
pubmed
12244054
uniprot
proteins
pubmed
12508121
uniprot
proteins
pubmed
12527768
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17150966
uniprot
proteins
pubmed
25075772
uniprot
proteins
pubmed
33818125
uniprot
proteins
sequence_length
156
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:12244054, ECO:0000269|PubMed:25075772}. Note=Detected in urine. {ECO:0000269|PubMed:25075772}.
uniprot
proteins