SHLD2
entrez
54537
canonical
uniprot
Q86V20
canonical
ensembl
ENSG00000122376
resolver
ensp
ENSP00000298784
resolver
ensp
ENSP00000298786
resolver
ensp
ENSP00000568100
resolver
ensp
ENSP00000568103
resolver
ensp
ENSP00000568104
resolver
ensp
ENSP00000568106
resolver
ensp
ENSP00000568107
resolver
ensp
ENSP00000568112
resolver
ensp
ENSP00000568113
resolver
ensp
ENSP00000568121
resolver
ensp
ENSP00000568132
resolver
ensp
ENSP00000568136
resolver
ensp
ENSP00000568142
resolver
ensp
ENSP00000568166
resolver
ensp
ENSP00000568168
resolver
ensp
ENSP00000568169
resolver
ensp
ENSP00000568171
resolver
ensp
ENSP00000584883
resolver
ensp
ENSP00000584884
resolver
ensp
ENSP00000614036
resolver
ensp
ENSP00000614038
resolver
ensp
ENSP00000614054
resolver
ensp
ENSP00000614060
resolver
ensp
ENSP00000614061
resolver
ensp
ENSP00000614062
resolver
genesymbol
SHLD2
resolver
genesymbol_syn
FAM35A
resolver
genesymbol_syn
RINN2
resolver
hgnc
HGNC:28773
resolver
uniprot
O95885
resolver
uniprot
Q9H991
resolver
uniprot_entry
SHLD2_HUMAN
resolver
uniprot_sec
O95885
resolver
uniprot_sec
Q9H991
resolver
amino_acid_sequence
MSGGSQVHIFWGAPIAPLKITVSEDTASLMSVADPWKKIQLLYSQHSLYLKDEKQHKNLENYKVPESIGSPDLSGHFLANCMNRHVHVKDDFVRSVSETQNIESQKIHSSRLSDITSSNMQICGFKSTVPHFTEEEKYQKLLSENKIRDEQPKHQPDICGKNFNTNLFQLGHKCAAVLDLVCSTEKINIGPEVVQRECVPTEYHEIQNQCLGLFSSNAVDKSRSEAAVRKVSDLKISTDTEFLSIITSSQVAFLAQKKDKRRSPVNKGNVNMETEPKASYGEIRIPEENSIQLDGFTEAYESGQNQAYSLELFSPVCPKTENSRIHINSDKGLEEHTGSQELFSSEDELPPNEIRIELCSSGILCSQLNTFHKSAIKRSCTSEDKVGQSEALSRVLQVAKKMKLISNGGDSAVEMDRRNVSEFKSIKKTSLIKNCDSKSQKYNCLVMVLSPCHVKEINIKFGPNSGSKVPLATVTVIDQSETKKKVFLWRTAAFWAFTVFLGDIILLTDVVIHEDQWIGETVLQSTFSSQLLNLGSYSSIQPEEYSSVVSEVVLQDLLAYVSSKHSYLRDLPPRQPQRVNSIDFVELEHLQPDVLVHAVLRVVDFTILTEAVYSYRGQKQKKVMLTVEQAQDQHYALVLWGPGAAWYPQLQRKKGVVLIKAQISELAFPITASQKIALNAHSSLKSIFSSLPNIVYTGCAKCGLELETDENRIYKQCFSCLPFTMKKIYYRPALMTAIDGRHDVCIRVESKLIEKILLNISADCLNRVIVPSSEITYGMVVADLFHSLLAVSAEPCVLKIQSLFVLDENSYPLQQDFSLLDFYPDIVKHGANARL
uniprot
proteins
function
FUNCTION: Component of the shieldin complex, which plays an important role in repair of DNA double-stranded breaks (DSBs) (PubMed:29656893, PubMed:29789392). During G1 and S phase of the cell cycle, the complex functions downstream of TP53BP1 to promote non-homologous end joining (NHEJ) and suppress DNA end resection (PubMed:29656893, PubMed:29789392). Mediates various NHEJ-dependent processes including immunoglobulin class-switch recombination, and fusion of unprotected telomeres (PubMed:29656893). {ECO:0000269|PubMed:29656893, ECO:0000269|PubMed:29789392}.
uniprot
proteins
mass_dalton
93705
uniprot
proteins
mutagenesis
MUTAGEN 6..11; /note="Missing: Fails to interact with SHLD3 or MAD2L2."; /evidence="ECO:0000269|PubMed:29656893
uniprot
proteins
protein_family
SHLD2 family
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15164054
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
29656893
uniprot
proteins
pubmed
29789392
uniprot
proteins
pubmed
34354233
uniprot
proteins
sequence_length
835
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:29656893, ECO:0000269|PubMed:29789392}. Chromosome {ECO:0000269|PubMed:29656893, ECO:0000305|PubMed:29789392}. Note=Localizes to nuclear foci in response to DNA damage. {ECO:0000269|PubMed:29656893, ECO:0000269|PubMed:29789392}.
uniprot
proteins