HTR2A
entrez
3356
canonical
uniprot
P28223
canonical
ensembl
ENSG00000102468
resolver
ensp
ENSP00000437737
resolver
ensp
ENSP00000441861
resolver
enst
ENST00000543956
resolver
genesymbol
HTR2A
resolver
genesymbol_syn
HTR2
resolver
hgnc
HGNC:5293
resolver
uniprot
A0A7P0PKG8
resolver
uniprot
B2RAC5
resolver
uniprot
B4DZ79
resolver
uniprot
F5GWE8
resolver
uniprot
Q5T8C0
resolver
uniprot_entry
5HT2A_HUMAN
resolver
uniprot_entry
A0A7P0PKG8_HUMAN
resolver
uniprot_sec
B2RAC5
resolver
uniprot_sec
B4DZ79
resolver
uniprot_sec
F5GWE8
resolver
uniprot_sec
Q5T8C0
resolver
activity_regulation
ACTIVITY REGULATION: G protein-coupled receptor activity is regulated by lipids: oleamide increases HTR2A-mediated activity (PubMed:35084960). Inhibited by IHCH-7179 small molecule: IHCH-7179 acts both as an agonist activator for HTR1A and as an antagonist inhibitor for HTR2A (PubMed:38552625). {ECO:0000269|PubMed:35084960, ECO:0000269|PubMed:38552625}.
uniprot
proteins
amino_acid_sequence
MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for 5-hydroxytryptamine (serotonin) (PubMed:1330647, PubMed:18703043, PubMed:19057895, PubMed:21645528, PubMed:22300836, PubMed:35084960, PubMed:38552625). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD) (PubMed:28129538, PubMed:35084960). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors (PubMed:28129538, PubMed:35084960). HTR2A is coupled to G(q)/G(11) G alpha proteins and activates phospholipase C-beta, releasing diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) second messengers that modulate the activity of phosphatidylinositol 3-kinase and promote the release of Ca(2+) ions from intracellular stores, respectively (PubMed:18703043, PubMed:28129538, PubMed:35084960). Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways (PubMed:28129538, PubMed:35084960). Affects neural activity, perception, cognition and mood (PubMed:18297054). Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction (By similarity). {ECO:0000250|UniProtKB:P35363, ECO:0000269|PubMed:1330647, ECO:0000269|PubMed:18297054, ECO:0000269|PubMed:18703043, ECO:0000269|PubMed:19057895, ECO:0000269|PubMed:21645528, ECO:0000269|PubMed:22300836, ECO:0000269|PubMed:28129538, ECO:0000269|PubMed:35084960, ECO:0000269|PubMed:38552625}.; FUNCTION: (Microbial infection) Acts as a receptor for human JC polyomavirus/JCPyV. {ECO:0000269|PubMed:24089568}.
uniprot
proteins
mass_dalton
52603
uniprot
proteins
mutagenesis
MUTAGEN 151; /note="W->A,F: Decreased ability to bind serotonin and psilocybin."; /evidence="ECO:0000269|PubMed:35084960"; MUTAGEN 155; /note="D->A: Abolished binding to serotonin and psilocybin."; /evidence="ECO:0000269|PubMed:35084960"; MUTAGEN 229; /note="L->A: Strongly increases dissociation of bound lysergic acid diethylamine, without affecting binding affinity. Reduces signaling via arrestins, but has no effect on signaling via the phosphatidylinositol-calcium second messenger system."; /evidence="ECO:0000269|PubMed:28129538"; MUTAGEN 239; /note="S->A: Decreased ability to bind serotonin and psilocybin."; /evidence="ECO:0000269|PubMed:35084960"; MUTAGEN 242; /note="S->A: Decreased ability to bind serotonin and psilocybin."; /evidence="ECO:0000269|PubMed:35084960"; MUTAGEN 280; /note="S->A: Increased ability of hallucinogens to desensitize the receptor."; /evidence="ECO:0000269|PubMed:24637012"; MUTAGEN 280; /note="S->D: Reduced receptor desensitization by nonhallucinogenic agonists."; /evidence="ECO:0000269|PubMed:24637012"; MUTAGEN 362; /note="L->A: Decreased ability to bind serotonin and psilocybin."; /evidence="ECO:0000269|PubMed:35084960"; MUTAGEN 463; /note="G->V: Loss of interaction with PATJ."; /evidence="ECO:0000269|PubMed:14988405"; MUTAGEN 465; /note="N->S: No effect on interaction with PATJ. Acquires the binding properties of HTR2C; when associated with S-470."; /evidence="ECO:0000269|PubMed:14988405"; MUTAGEN 470; /note="C->S: No effect on interaction with PATJ. Acquires the binding properties of HTR2C; when associated with S-465."; /evidence="ECO:0000269|PubMed:14988405"; MUTAGEN 471; /note="V->A: Loss of interaction with PATJ, CASK, APBA1, DLG1 and DLG4."; /evidence="ECO:0000269|PubMed:14988405
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10391209
uniprot
proteins
pubmed
10581480
uniprot
proteins
pubmed
11150294
uniprot
proteins
pubmed
1323014
uniprot
proteins
pubmed
1330647
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
14988405
uniprot
proteins
pubmed
15057823
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
1722404
uniprot
proteins
pubmed
18297054
uniprot
proteins
pubmed
18476671
uniprot
proteins
pubmed
18703043
uniprot
proteins
pubmed
19057895
uniprot
proteins
pubmed
20945968
uniprot
proteins
pubmed
21645528
uniprot
proteins
pubmed
22300836
uniprot
proteins
pubmed
24089568
uniprot
proteins
pubmed
24637012
uniprot
proteins
pubmed
28129538
uniprot
proteins
pubmed
35084960
uniprot
proteins
pubmed
36171289
uniprot
proteins
pubmed
38552625
uniprot
proteins
pubmed
8035173
uniprot
proteins
pubmed
8655141
uniprot
proteins
sequence_length
471
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28129538}; Multi-pass membrane protein {ECO:0000269|PubMed:36171289}. Cell projection, dendrite {ECO:0000250|UniProtKB:P35363}. Cell projection, axon {ECO:0000250|UniProtKB:P14842}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:P14842}. Membrane, caveola {ECO:0000250|UniProtKB:P14842}. Presynapse {ECO:0000250|UniProtKB:P14842}.
uniprot
proteins
transmembrane_region
TRANSMEM 81..97; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:36171289, ECO:0007744|PDB:7RAN"; TRANSMEM 112..137; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:36171289, ECO:0007744|PDB:7RAN"; TRANSMEM 147..171; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:36171289, ECO:0007744|PDB:7RAN"; TRANSMEM 192..215; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:36171289, ECO:0007744|PDB:7RAN"; TRANSMEM 233..258; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:36171289, ECO:0007744|PDB:7RAN"; TRANSMEM 323..348; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:36171289, ECO:0007744|PDB:7RAN"; TRANSMEM 357..382; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:36171289, ECO:0007744|PDB:7RAN
uniprot
proteins