Tgfb2
entrez
81809
canonical
uniprot
Q07257
canonical
ensembl
ENSRNOG00000002418
resolver
ensp
ENSRNOP00000003313
resolver
enst
ENSRNOT00000003313
resolver
genesymbol
Tgfb2
resolver
uniprot
G3V6B1
resolver
uniprot
Q63574
resolver
uniprot
Q9QW26
resolver
uniprot
Q9R281
resolver
uniprot
Q9R298
resolver
uniprot
Q9R2B8
resolver
uniprot
Q9WUQ8
resolver
uniprot_entry
G3V6B1_RAT
resolver
uniprot_entry
TGFB2_RAT
resolver
uniprot_sec
Q63574
resolver
uniprot_sec
Q9QW26
resolver
uniprot_sec
Q9R281
resolver
uniprot_sec
Q9R298
resolver
uniprot_sec
Q9R2B8
resolver
uniprot_sec
Q9WUQ8
resolver
amino_acid_sequence
MHYCVLRTFLLLHLVPVALSLSTCSTLDMDQFMRKRIEAIRGQILSKLKLTSPPEDYPEPDEVPPEVISIYNSTRDLLQEKASRRAAACERERSDEEYYAKEVYKIDMPSHFPSETVCPVVTTSSGSVGSFCSIQSQVLCGYLDAIPPTFYRPYFRIVRFDVSTMEKNASNLVKAEFRVFRLQNPKARVAEQRIELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGFKISLHCPCCTFIPSNNYIIPNKSQELEARFAGIDGTSTYASGDQKTIKSTRKKSSGKTPHLLLMLLPSYRLESQQSSRRRKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHTKVLSLYNTINPEASASPCCVSQDLEPLTILYYIGNTPKIEQLSNMIVKSCKCS
uniprot
proteins
function
FUNCTION: [Transforming growth factor beta-2 proprotein]: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. {ECO:0000250|UniProtKB:P01137, ECO:0000250|UniProtKB:P04202}.; FUNCTION: [Latency-associated peptide]: Required to maintain the Transforming growth factor beta-2 (TGF-beta-2) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-2 and regulates its activation via interaction with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2. {ECO:0000250|UniProtKB:P01137, ECO:0000250|UniProtKB:P04202}.; FUNCTION: [Transforming growth factor beta-2]: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains remain non-covalently linked rendering TGF-beta-2 inactive during storage in extracellular matrix (By similarity). At the same time, LAP chain interacts with 'milieu molecules', such as LTBP1 and LRRC32/GARP, that control activation of TGF-beta-2 and maintain it in a latent state during storage in extracellular milieus (By similarity). Once activated following release of LAP, TGF-beta-2 acts by binding to TGF-beta receptors (TGFBR1 and TGFBR2), which transduce signal (By similarity). {ECO:0000250|UniProtKB:P01137, ECO:0000250|UniProtKB:P04202, ECO:0000250|UniProtKB:P61812}.
uniprot
proteins
mass_dalton
50534
uniprot
proteins
post_translational_modification
PTM: [Transforming growth factor beta-2]: The precursor proprotein is cleaved in the Golgi apparatus to form Transforming growth factor beta-2 (TGF-beta-2) and Latency-associated peptide (LAP) chains, which remain non-covalently linked, rendering TGF-beta-2 inactive. {ECO:0000250|UniProtKB:P01137}.
uniprot
proteins
protein_family
TGF-beta family
uniprot
proteins
pubmed
10899565
uniprot
proteins
pubmed
11014222
uniprot
proteins
pubmed
26858265
uniprot
proteins
pubmed
8486763
uniprot
proteins
pubmed
8509457
uniprot
proteins
sequence_length
442
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Latency-associated peptide]: Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:P01137}.; SUBCELLULAR LOCATION: [Transforming growth factor beta-2]: Secreted {ECO:0000250|UniProtKB:P01137}.
uniprot
proteins