Hmox1
entrez
15368
canonical
uniprot
P14901
canonical
ensembl
ENSMUSG00000005413
resolver
ensp
ENSMUSP00000005548
resolver
enst
ENSMUST00000005548
resolver
genesymbol
Hmox1
resolver
uniprot
Q3U5U6
resolver
uniprot_entry
HMOX1_MOUSE
resolver
uniprot_entry
Q3U5U6_MOUSE
resolver
amino_acid_sequence
MERPQPDSMPQDLSEALKEATKEVHIQAENAEFMKNFQKGQVSREGFKLVMASLYHIYTALEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQEIIPCTPATQHYVKRLHEVGRTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSSGEGLAFFTFPNIDSPTKFKQLYRARMNTLEMTPEVKHRVTEEAKTAFLLNIELFEELQVMLTEEHKDQSPSQMASLRQRPASLVQDTAPAETPRGKPQISTSSSQTPLLQWVLTLSFLLATVAVGIYAM
uniprot
proteins
ec_number
1.14.14.18
uniprot
proteins
function
FUNCTION: [Heme oxygenase 1]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron (By similarity) Affords protection against programmed cell death and this cytoprotective effect relies on its ability to catabolize free heme and prevent it from sensitizing cells to undergo apoptosis (By similarity). {ECO:0000250|UniProtKB:P09601}.; FUNCTION: [Heme oxygenase 1 soluble form]: Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron. {ECO:0000250|UniProtKB:P09601}.
uniprot
proteins
mass_dalton
32929
uniprot
proteins
post_translational_modification
PTM: A soluble form arises by proteolytic removal of the membrane anchor. {ECO:0000250|UniProtKB:P09601}.
uniprot
proteins
protein_family
Heme oxygenase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18400743
uniprot
proteins
pubmed
18474359
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
32973183
uniprot
proteins
pubmed
3409220
uniprot
proteins
pubmed
8288554
uniprot
proteins
sequence_length
289
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P09601}; Single-pass type IV membrane protein {ECO:0000255}; Cytoplasmic side {ECO:0000250|UniProtKB:P09601}.
uniprot
proteins
transmembrane_region
TRANSMEM 267..289; /note="Helical; Anchor for type IV membrane protein"; /evidence="ECO:0000255
uniprot
proteins