Mmp3
entrez
17392
canonical
uniprot
P28862
canonical
ensembl
ENSMUSG00000043613
resolver
ensp
ENSMUSP00000034497
resolver
enst
ENSMUST00000034497
resolver
genesymbol
Mmp3
resolver
uniprot
F6Q674
resolver
uniprot
Q3UFJ0
resolver
uniprot
Q922W6
resolver
uniprot_entry
F6Q674_MOUSE
resolver
uniprot_entry
MMP3_MOUSE
resolver
uniprot_entry
Q3UFJ0_MOUSE
resolver
uniprot_entry
Q922W6_MOUSE
resolver
amino_acid_sequence
MKGLPVLLWLCVVVCSSYPLHDSARDDDAGMELLQKYLENYYGLAKDVKQFIKKKDSSLIVKKIQEMQKFLGLEMTGKLDSNTMELMHKPRCGVPDVGGFSTFPGSPKWRKSHITYRIVNYTPDLPRQSVDSAIEKALKVWEEVTPLTFSRISEGEADIMISFAVGEHGDFVPFDGPGTVLAHAYAPGPGINGDAHFDDDERWTEDVTGTNLFLVAAHELGHSLGLYHSAKAEALMYPVYKSSTDLSRFHLSQDDVDGIQSLYGTPTASPDVLVVPTKSNSLEPETSPMCSSTLFFDAVSTLRGEVLFFKDRHFWRKSLRTPEPEFYLISSFWPSLPSNMDAAYEVTNRDTVFIFKGNQFWAIRGHEELAGYPKSIHTLGLPATVKKIDAAISNKEKRKTYFFVEDKYWRFDEKKQSMEPGFPRKIAEDFPGVDSRVDAVFEAFGFLYFFSGSSQLEFDPNAKKVTHILKSNSWFNC
uniprot
proteins
ec_number
3.4.24.17
uniprot
proteins
function
FUNCTION: Metalloproteinase with a rather broad substrate specificity that can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates different molecules including growth factors, plasminogen or other matrix metalloproteinases such as MMP9. Once released into the extracellular matrix (ECM), the inactive pro-enzyme is activated by the plasmin cascade signaling pathway. Also acts intracellularly. For example, in dopaminergic neurons, gets activated by the serine protease HTRA2 upon stress and plays a pivotal role in DA neuronal degeneration by mediating microglial activation and alpha-synuclein/SNCA cleavage (PubMed:17116747). In addition, plays a role in immune response and possesses antiviral activity against various viruses (PubMed:35940311). Mechanistically, translocates from the cytoplasm into the cell nucleus upon virus infection to influence NF-kappa-B activities (PubMed:35940311). {ECO:0000250|UniProtKB:P08254, ECO:0000269|PubMed:17116747, ECO:0000269|PubMed:35940311}.
uniprot
proteins
mass_dalton
53845
uniprot
proteins
protein_family
Peptidase M10A family
uniprot
proteins
pubmed
1398148
uniprot
proteins
pubmed
17116747
uniprot
proteins
pubmed
2744464
uniprot
proteins
pubmed
35940311
uniprot
proteins
sequence_length
477
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305}.
uniprot
proteins