Ppp6c
entrez
171121
canonical
uniprot
Q64620
canonical
ensembl
ENSRNOG00000015145
resolver
ensembl
ENSRNOG00055008617
resolver
ensembl
ENSRNOG00060028062
resolver
ensembl
ENSRNOG00065027635
resolver
ensp
ENSRNOP00000021176
resolver
ensp
ENSRNOP00055011620
resolver
ensp
ENSRNOP00060040695
resolver
ensp
ENSRNOP00065039092
resolver
enst
ENSRNOT00000021176
resolver
enst
ENSRNOT00055014548
resolver
enst
ENSRNOT00060048783
resolver
enst
ENSRNOT00065047666
resolver
genesymbol
Ppp6c
resolver
genesymbol_syn
Ppv
resolver
uniprot
Q6AZ47
resolver
uniprot_entry
PPP6_RAT
resolver
uniprot_sec
Q6AZ47
resolver
amino_acid_sequence
MAPLDLDKYVEIARQCKYLPENDLKRLCDYVCDLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLLALKAKWPDRITLLRGNHESRQITQVYGFYDECQTKYGNANAWRYCTKVFDMLTVAALIDEQILCVHGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPEDVDTWAISPRGAGWLFGAKVTNEFVHINNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKDVNTREPKLFRAVPDSERVIPPRTTTPYFL
uniprot
proteins
ec_number
3.1.3.16
uniprot
proteins
function
FUNCTION: Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. During mitosis, regulates spindle positioning. Down-regulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. Also participates in the innate immune defense against viruses by desphosphorylating RIGI, an essential step that triggers RIG-I-mediated signaling activation. {ECO:0000250|UniProtKB:O00743}.
uniprot
proteins
mass_dalton
35159
uniprot
proteins
protein_family
PP-6 (PP-V) subfamily
uniprot
proteins
protein_family
PPP phosphatase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8077208
uniprot
proteins
sequence_length
305
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250|UniProtKB:O00743}. Cytoplasm {ECO:0000250|UniProtKB:O00743}.
uniprot
proteins