Arhgap24
entrez
305156
canonical
uniprot
Q5U2Z7
canonical
ensembl
ENSRNOG00000056944
resolver
ensp
ENSRNOP00000072212
resolver
ensp
ENSRNOP00000075613
resolver
ensp
ENSRNOP00000099081
resolver
enst
ENSRNOT00000080758
resolver
enst
ENSRNOT00000089800
resolver
enst
ENSRNOT00000141948
resolver
genesymbol
Arhgap24
resolver
uniprot
A0A0G2K2E5
resolver
uniprot
A0A0X1KG81
resolver
uniprot
A0ABK0L5N6
resolver
uniprot
Q6I7R2
resolver
uniprot_entry
A0A0G2K2E5_RAT
resolver
uniprot_entry
A0A0X1KG81_RAT
resolver
uniprot_entry
A0ABK0L5N6_RAT
resolver
uniprot_entry
RHG24_RAT
resolver
uniprot_sec
Q6I7R2
resolver
amino_acid_sequence
MEENCDSTENPHSQGRQNATKCGWLRKQGGFVKTWHTRWFVLKGDQLHYFKDEDETKPLGTIFLPGNKVIEHPCNEESPGKFLFEVVPGGERDRMTANHESYLLMASTQNDMEDWVKSIRRVIWGPFGGGIFGQKLEDTVRYEKRYGNRLAPMLVEQCVDFIRQRGLKEEGLFRLPGQANLVKELQDAFDCGEKPSFDSNTDVHTVASLLKLYLRELPEPVVPYAKYEDFLSCATLLSKEEEAGVKELTKQVKSLPVVNYNLLKYICRFLDEVQSYSGVNKMSAQNLATVFGPNILRPKVEDPLTIMEGTVVVQQLMSVMISKHDRLFPKDTEPQSKPQEGPNSNNNDGHKKVTMGQLQNKENNNTKESPVRRCSWDKPESPQRSSMDNGSPTALSGSKTNSPRNSIHKLDVSRSPPLTVKKNPAFNKGSGIVTNGSFSSSNAEGVEKTQTTPNGSLQARRTSSLKSSGTKMGTHSVQNGTVRMGILNTDTLGNSLNGRSMSWLPNGYVTLRDNKQKEPAGESGQHNRLSTYDNVHQQFSLMNLDDKHSVDSATWSTSSCEISLPENSNSCRSSTTTCPEQDFYGGNFEDPVLDGPPQDDLSHPGDYENKSDRRSVGGRSSRATSSSDNSETFVGNTSSNHSALHSLVSSLKQEMTKQKIEYESRIKSLEQRNLTLETEMLNLHDELDQERKKFTMIEIKMRNAERAKEDAEKRNDMLQKEMEQFFSTFGDLTVEPRRSERGNTIWIQ
uniprot
proteins
function
FUNCTION: Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
84144
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by ROCK, leading to activate the RacGAP activity. {ECO:0000250}.
uniprot
proteins
pubmed
15200410
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
748
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Cell junction, adherens junction {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}. Cell projection {ECO:0000250}. Note=Localizes to actin stress fibers. In migrating cells, localizes to membrane lamellae and protusions (By similarity). {ECO:0000250}.
uniprot
proteins