Dnajb2
entrez
56812
canonical
uniprot
Q9QYI5
canonical
ensembl
ENSMUSG00000026203
resolver
ensp
ENSMUSP00000052520
resolver
ensp
ENSMUSP00000080796
resolver
ensp
ENSMUSP00000140566
resolver
ensp
ENSMUSP00000140588
resolver
ensp
ENSMUSP00000140634
resolver
ensp
ENSMUSP00000140637
resolver
genesymbol
Dnajb2
resolver
genesymbol_syn
Dnajb10
resolver
uniprot
Q3TB24
resolver
uniprot
Q8BPF6
resolver
uniprot
Q921S2
resolver
uniprot_entry
DNJB2_MOUSE
resolver
uniprot_sec
Q3TB24
resolver
uniprot_sec
Q8BPF6
resolver
uniprot_sec
Q921S2
resolver
amino_acid_sequence
MASYYEILDVPRSASPDDIKKAYRKKALQWHPDKNPDNKEFAEKKFKEVAEAYEVLSDKHKREIYDRYGREGLTGAGSGPSRSETGGAGPGFTFTFRSPEEVFREFFGSGDPFSELFDDLGVFSELQNQGPRLTGPFFTFSSSFPANSDFSSSSFSFSPGAGAFRSVSTSTTFVQGRRITTRRIMENGQERVEVEEDGQLKSVSINGVPDDLALGLELSRREQQPSVAPGLGVMQVRPTSLSRPPDHDLSEDEDLQLAMAYSLSEMEAAGQKPAGGRGAQQRQHGQPKAQHRDLDVGGTHKSVRGEAAKLSPSSEEKASRCHIL
uniprot
proteins
function
FUNCTION: Functions as a co-chaperone, regulating the substrate binding and activating the ATPase activity of chaperones of the HSP70/heat shock protein 70 family. In parallel, also contributes to the ubiquitin-dependent proteasomal degradation of misfolded proteins. Thereby, may regulate the aggregation and promote the functional recovery of misfolded proteins like HTT, MC4R, PRKN, RHO and SOD1 and be crucial for many biological processes. Isoform 1 which is localized to the endoplasmic reticulum membranes may specifically function in ER-associated protein degradation of misfolded proteins. {ECO:0000250|UniProtKB:P25686}.
uniprot
proteins
mass_dalton
35593
uniprot
proteins
post_translational_modification
PTM: Ubiquitinated by STUB1; does not lead to proteasomal degradation. {ECO:0000250|UniProtKB:P25686}.
uniprot
proteins
pubmed
11147971
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16452087
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
324
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm {ECO:0000250|UniProtKB:P25686}. Nucleus {ECO:0000250|UniProtKB:P25686}.; SUBCELLULAR LOCATION: [Isoform 1]: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P25686}; Lipid-anchor {ECO:0000250|UniProtKB:P25686}; Cytoplasmic side {ECO:0000250|UniProtKB:P25686}.
uniprot
proteins