Ak6
entrez
102238592
canonical
uniprot
Q5EB68
canonical
ensembl
ENSRNOG00000063018
resolver
ensp
ENSRNOP00000057879
resolver
genesymbol
Ak6
resolver
genesymbol_syn
Cinap
resolver
uniprot
A6XB81
resolver
uniprot_entry
KAD6_RAT
resolver
uniprot_sec
A6XB81
resolver
amino_acid_sequence
MKLPNILLTGTPGVGKTTLGKELASRSGLKYVNVGDLAREGHLYDGYDEEYGCPILDEDRVVDELEPQMTEGGVIVDYHGCDFFPERWFHIVFVLRTDNGILYKRLETRGYHEKKLQDNIQCEIFQVLYEEAMASYKEEIVHQLPSNEPEQLEDNINQISKWIEQWVKDHNP
uniprot
proteins
ec_number
2.7.4.3
uniprot
proteins
function
FUNCTION: Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Also has ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis. May be involved in regulation of Cajal body (CB) formation. {ECO:0000255|HAMAP-Rule:MF_03173}.
uniprot
proteins
mass_dalton
19944
uniprot
proteins
protein_family
AK6 subfamily
uniprot
proteins
protein_family
Adenylate kinase family
uniprot
proteins
pubmed
15489334
uniprot
proteins
sequence_length
172
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03173}. Nucleus, nucleoplasm {ECO:0000255|HAMAP-Rule:MF_03173}. Nucleus, Cajal body {ECO:0000255|HAMAP-Rule:MF_03173}. Note=Displays widespread diffuse nucleoplasmic distribution but not detected in nucleoli. Detected in Cajal bodies but not in all cells. {ECO:0000255|HAMAP-Rule:MF_03173}.
uniprot
proteins