ALOX15B
entrez
247
canonical
uniprot
O15296
canonical
ensembl
ENSG00000179593
resolver
ensp
ENSP00000369520
resolver
ensp
ENSP00000369530
resolver
ensp
ENSP00000460332
resolver
genesymbol
ALOX15B
resolver
hgnc
HGNC:434
resolver
uniprot
D3DTR2
resolver
uniprot
Q8IYQ2
resolver
uniprot
Q8TEV3
resolver
uniprot
Q8TEV4
resolver
uniprot
Q8TEV5
resolver
uniprot
Q8TEV6
resolver
uniprot
Q9UKM4
resolver
uniprot_entry
LX15B_HUMAN
resolver
uniprot_sec
D3DTR2
resolver
uniprot_sec
Q8IYQ2
resolver
uniprot_sec
Q8TEV3
resolver
uniprot_sec
Q8TEV4
resolver
uniprot_sec
Q8TEV5
resolver
uniprot_sec
Q8TEV6
resolver
uniprot_sec
Q9UKM4
resolver
amino_acid_sequence
MAEFRVRVSTGEAFGAGTWDKVSVSIVGTRGESPPLPLDNLGKEFTAGAEEDFQVTLPEDVGRVLLLRVHKAPPVLPLLGPLAPDAWFCRWFQLTPPRGGHLLFPCYQWLEGAGTLVLQEGTAKVSWADHHPVLQQQRQEELQARQEMYQWKAYNPGWPHCLDEKTVEDLELNIKYSTAKNANFYLQAGSAFAEMKIKGLLDRKGLWRSLNEMKRIFNFRRTPAAEHAFEHWQEDAFFASQFLNGLNPVLIRRCHYLPKNFPVTDAMVASVLGPGTSLQAELEKGSLFLVDHGILSGIQTNVINGKPQFSAAPMTLLYQSPGCGPLLPLAIQLSQTPGPNSPIFLPTDDKWDWLLAKTWVRNAEFSFHEALTHLLHSHLLPEVFTLATLRQLPHCHPLFKLLIPHTRYTLHINTLARELLIVPGQVVDRSTGIGIEGFSELIQRNMKQLNYSLLCLPEDIRTRGVEDIPGYYYRDDGMQIWGAVERFVSEIIGIYYPSDESVQDDRELQAWVREIFSKGFLNQESSGIPSSLETREALVQYVTMVIFTCSAKHAAVSAGQFDSCAWMPNLPPSMQLPPPTSKGLATCEGFIATLPPVNATCDVILALWLLSKEPGDQRPLGTYPDEHFTEEAPRRSIATFQSRLAQISRGIQERNQGLVLPYTYLDPPLIENSVSI
uniprot
proteins
ec_number
1.13.11.-
uniprot
proteins
ec_number
1.13.11.33
uniprot
proteins
function
FUNCTION: [Isoform A]: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids (PUFAs) generating a spectrum of bioactive lipid mediators (Probable) (PubMed:10542053, PubMed:10625675, PubMed:12704195, PubMed:17493578, PubMed:18311922, PubMed:24282679, PubMed:24497644, PubMed:32404334, PubMed:9177185). It inserts peroxyl groups at C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing (15S)-hydroperoxyeicosatetraenoate/(15S)-HPETE (Probable) (PubMed:10625675, PubMed:11956198, PubMed:12704195, PubMed:17493578, PubMed:24282679, PubMed:24497644, PubMed:9177185). Also peroxidizes linoleate ((9Z,12Z)-octadecadienoate) to 13-hydroperoxyoctadecadienoate/13-HPODE (Probable) (PubMed:10542053, PubMed:27435673). Oxygenates arachidonyl derivatives such as 2-arachidonoylglycerol (2-AG) leading to the production and extracellular release of 15-hydroxyeicosatetraenoyl glycerol (15-HETE-G) that acts as a peroxisome proliferator-activated receptor alpha agonist (PubMed:11956198, PubMed:17493578, PubMed:18311922). Has the ability to efficiently class-switch ALOX5 pro-inflammatory mediators into anti-inflammatory intermediates (PubMed:27145229). Participates in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs) resolvin D5 ((7S,17S)-diHPDHA), which can actively down-regulate the immune response and have anti-aggregation properties with platelets (PubMed:32404334). In addition to free PUFAs hydrolyzed from phospholipids, it directly oxidizes PUFAs esterified to membrane-bound phospholipids (PubMed:27435673). Has no detectable 8S-lipoxygenase activity on arachidonate but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE (Probable). May regulate progression through the cell cycle and cell proliferation (PubMed:11839751, PubMed:12704195). May also regulate cytokine secretion by macrophages and therefore play a role in the immune response (PubMed:18067895). May also regulate macrophage differentiation into proatherogenic foam cells (PubMed:22912809). {ECO:0000269|PubMed:10542053, ECO:0000269|PubMed:10625675, ECO:0000269|PubMed:11839751, ECO:0000269|PubMed:11956198, ECO:0000269|PubMed:12704195, ECO:0000269|PubMed:17493578, ECO:0000269|PubMed:18067895, ECO:0000269|PubMed:18311922, ECO:0000269|PubMed:22912809, ECO:0000269|PubMed:24282679, ECO:0000269|PubMed:24497644, ECO:0000269|PubMed:27145229, ECO:0000269|PubMed:27435673, ECO:0000269|PubMed:32404334, ECO:0000269|PubMed:9177185, ECO:0000305|PubMed:10542053, ECO:0000305|PubMed:16112079, ECO:0000305|PubMed:27145229, ECO:0000305|PubMed:27435673}.; FUNCTION: [Isoform B]: Does not convert arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid/(15S)-HPETE. {ECO:0000269|PubMed:12704195}.
uniprot
proteins
mass_dalton
75857
uniprot
proteins
mutagenesis
MUTAGEN 39; /note="D->A: Abolishes calcium-dependent association with membranes; when associated with A-44 and A-85."; /evidence="ECO:0000269|PubMed:24497644"; MUTAGEN 44; /note="E->A: Abolishes calcium-dependent association with membranes; when associated with A-39 and A-85."; /evidence="ECO:0000269|PubMed:24497644"; MUTAGEN 85; /note="D->A: Abolishes calcium-dependent association with membranes; when associated with A-39 and A-44."; /evidence="ECO:0000269|PubMed:24497644"; MUTAGEN 602; /note="D->Y: No effect on the stereoselectivity of the oxygenation reaction. Completely changes the stereoselectivity of the oxygenation reaction to produce (8S)-HPETE instead of (15S)-HPETE; when associated with H-603."; /evidence="ECO:0000269|PubMed:10625675"; MUTAGEN 603; /note="V->H: Changes the stereoselectivity of the oxygenation reaction. Completely changes the stereoselectivity of the oxygenation reaction to produce (8S)-HPETE instead of (15S)-HPETE; when associated with Y-602."; /evidence="ECO:0000269|PubMed:10625675
uniprot
proteins
pathway_participation
PATHWAY: Lipid metabolism; hydroperoxy eicosatetraenoic acid biosynthesis. {ECO:0000269|PubMed:10542053}.
uniprot
proteins
protein_family
Lipoxygenase family
uniprot
proteins
pubmed
10542053
uniprot
proteins
pubmed
10625675
uniprot
proteins
pubmed
11350124
uniprot
proteins
pubmed
11839751
uniprot
proteins
pubmed
11956198
uniprot
proteins
pubmed
12704195
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16112079
uniprot
proteins
pubmed
16625196
uniprot
proteins
pubmed
17493578
uniprot
proteins
pubmed
18067895
uniprot
proteins
pubmed
18311922
uniprot
proteins
pubmed
18755188
uniprot
proteins
pubmed
22912809
uniprot
proteins
pubmed
24282679
uniprot
proteins
pubmed
24497644
uniprot
proteins
pubmed
27145229
uniprot
proteins
pubmed
27435673
uniprot
proteins
pubmed
32404334
uniprot
proteins
pubmed
9177185
uniprot
proteins
sequence_length
676
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform A]: Nucleus {ECO:0000269|PubMed:12704195}. Note=Other isoforms are excluded from the nucleus. {ECO:0000269|PubMed:12704195}.; SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:12704195}. Cell membrane {ECO:0000269|PubMed:12704195, ECO:0000269|PubMed:27435673}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:12704195}. Membrane {ECO:0000269|PubMed:10542053, ECO:0000269|PubMed:24497644}; Peripheral membrane protein {ECO:0000269|PubMed:24497644}. Cell junction, adherens junction {ECO:0000269|PubMed:12704195}. Cell junction, focal adhesion {ECO:0000269|PubMed:12704195}. Note=Predominantly cytosolic; becomes enriched at membranes upon calcium binding. {ECO:0000269|PubMed:10542053, ECO:0000269|PubMed:12704195, ECO:0000269|PubMed:24497644, ECO:0000269|PubMed:27435673}.
uniprot
proteins