Terf2ip
entrez
57321
canonical
uniprot
Q91VL8
canonical
ensembl
ENSMUSG00000033430
resolver
ensp
ENSMUSP00000052170
resolver
enst
ENSMUST00000052138
resolver
genesymbol
Terf2ip
resolver
genesymbol_syn
Rap1
resolver
uniprot
D3YWE8
resolver
uniprot
Q543F4
resolver
uniprot
Q8C2Y1
resolver
uniprot
Q9JJE8
resolver
uniprot
Q9JJE9
resolver
uniprot_entry
TE2IP_MOUSE
resolver
uniprot_sec
D3YWE8
resolver
uniprot_sec
Q543F4
resolver
uniprot_sec
Q8C2Y1
resolver
uniprot_sec
Q9JJE8
resolver
uniprot_sec
Q9JJE9
resolver
amino_acid_sequence
MAEAMDLGKDPNGPTHSSTLFVREDGSAMSFYVRPSSAKRRLSTLILHGGGTVCRVQEPGAVLLAQPGEALAEASGDFISTQYILDCVDRNEKLDLEAYRLGLTEQASDPKPGASTEGSTEPEPQPLTGRIAYTDAEDVAILTYVKENARSPSSVTGNALWKAMEKSSLTQHSWQSLKDRYLKHLRGQEHKYLLGNAPVSPSSQKLKRKAEQDPEAADSGEPQNKRAPDLPEEECVKGEIKENGEADNKLFEEAAPEFGEAVVDESPDFEIHITMCDGDPPTPEEDSETQPDEEEEEPKVSTQEVGTAIKVIRQLMEKFNLDLSTVTQALLKNSGELEATSSFLESGRRPDGYPIWCRQDDLDLQKDDDDTKNALVKKFGAQNVARRIEFRKK
uniprot
proteins
function
FUNCTION: Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. {ECO:0000269|PubMed:20339076, ECO:0000269|PubMed:20622869, ECO:0000269|PubMed:20622870}.
uniprot
proteins
mass_dalton
43353
uniprot
proteins
protein_family
RAP1 family
uniprot
proteins
pubmed
14659874
uniprot
proteins
pubmed
15345747
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17242355
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20339076
uniprot
proteins
pubmed
20622869
uniprot
proteins
pubmed
20622870
uniprot
proteins
pubmed
21183079
uniprot
proteins
sequence_length
393
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:20622870}. Cytoplasm {ECO:0000269|PubMed:20622870}. Chromosome {ECO:0000269|PubMed:20622869}. Chromosome, telomere {ECO:0000269|PubMed:20622869}. Note=Associates with chromosomes, both at telomeres and in extratelomeric sites (PubMed:20622869). Also exists as a cytoplasmic form, where it associates with the IKK complex (PubMed:20622870). {ECO:0000269|PubMed:20622869, ECO:0000269|PubMed:20622870}.
uniprot
proteins