Tcf7
entrez
21414
canonical
uniprot
Q00417
canonical
ensembl
ENSMUSG00000000782
resolver
ensp
ENSMUSP00000084055
resolver
ensp
ENSMUSP00000104699
resolver
ensp
ENSMUSP00000258372
resolver
ensp
ENSMUSP00000258376
resolver
ensp
ENSMUSP00000330857
resolver
ensp
ENSMUSP00000330858
resolver
ensp
ENSMUSP00000330859
resolver
enst
ENSMUST00000109071
resolver
genesymbol
Tcf7
resolver
genesymbol_syn
Tcf-1
resolver
genesymbol_syn
Tcf1
resolver
uniprot
A0A5K1VVQ7
resolver
uniprot
Q80UF1
resolver
uniprot_entry
A0A5K1VVQ7_MOUSE
resolver
uniprot_entry
Q80UF1_MOUSE
resolver
uniprot_entry
TCF7_MOUSE
resolver
amino_acid_sequence
MPQLDSGGGGAGRGDDLGAPDELLAFQDEGEEQDDKNRDSPVGPERDLAELKSSLVNESEGAAAGAGVPGPGVRVHGEAEGAPEALGREHTSQRLFPDKLPESLEDGLKAPECTSGMYKETVYSAFNLLMPYPPASGAGQHPQPQPPLHNKPGQPPHGVPQLSPLYEHFSSPHPTPAPADISQKQGVHRPLQTPDLSGFYSLTSGSMGQLPHTVSWPSPPLYPLSPSCGYRQHFPAPTAAPGAPYPRFTHPSLMLGSGVPGHPAAIPHPAIVPSSGKQELQPYDRNLKTQAEPKAEKEAKKPVIKKPLNAFMLYMKEMRAKVIAECTLKESAAINQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKRRSREKHQESTTGGKRNAFGTYPEKAAAPAPFLPMTVL
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Tcf7 may allow the formation of epithelial tumors. {ECO:0000269|PubMed:10489374}.
uniprot
proteins
function
FUNCTION: Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages (PubMed:17218525). Inhibits the developmental program of IL17A effector gamma-delta T-cell subsets via regulating the transcription of T-cell lineage effector proteins (PubMed:23562159, PubMed:30413363). Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells (PubMed:23562159). TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1 (By similarity). May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. {ECO:0000250, ECO:0000269|PubMed:11477404, ECO:0000269|PubMed:17218525, ECO:0000269|PubMed:23562159, ECO:0000269|PubMed:30413363}.
uniprot
proteins
mass_dalton
45465
uniprot
proteins
protein_family
TCF/LEF family
uniprot
proteins
pubmed
10489374
uniprot
proteins
pubmed
11477404
uniprot
proteins
pubmed
17218525
uniprot
proteins
pubmed
1827138
uniprot
proteins
pubmed
23562159
uniprot
proteins
pubmed
27713059
uniprot
proteins
pubmed
30413363
uniprot
proteins
pubmed
8622675
uniprot
proteins
sequence_length
419
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus.
uniprot
proteins