Ddx4
entrez
13206
canonical
uniprot
Q61496
canonical
ensembl
ENSMUSG00000021758
resolver
ensp
ENSMUSP00000075157
resolver
ensp
ENSMUSP00000096769
resolver
ensp
ENSMUSP00000287118
resolver
ensp
ENSMUSP00000332047
resolver
enst
ENSMUST00000075748
resolver
enst
ENSMUST00000099166
resolver
genesymbol
Ddx4
resolver
genesymbol_syn
Mvh
resolver
genesymbol_syn
Vasa
resolver
uniprot
F6PWR5
resolver
uniprot
Q3V086
resolver
uniprot
Q9D5X7
resolver
uniprot_entry
DDX4_MOUSE
resolver
uniprot_entry
F6PWR5_MOUSE
resolver
uniprot_entry
Q3V086_MOUSE
resolver
uniprot_sec
Q9D5X7
resolver
amino_acid_sequence
MGDEDWEAEILKPHVSSYVPVFEKDKYSSGANGDTFNRTSASSDIGESSKKENTSTTGGFGRGKGFGNRGFLNNKFEEGDSSGFWKESNNDCEDNQTRSRGFSKRGGCQDGNDSEASGPFRRGGRGSFRGCRGGFGLGRPNSESDQDQGTQRGGGLFGSRKPAASDSGNGDTYQSRSGSGRGGYKGLNEEVVTGSGKNSWKSETEGGESSDSQGPKVTYIPPPPPEDEDSIFAHYQTGINFDKYDTILVEVSGHDAPPAILTFEEANLCQTLNNNIAKAGYTKLTPVQKYSIPIVLAGRDLMACAQTGSGKTAAFLLPILAHMMRDGITASRFKELQEPECIIVAPTRELINQIYLEARKFSFGTCVRAVVIYGGTQFGHSVRQIVQGCNILCATPGRLMDIIGKEKIGLKQVKYLVLDEADRMLDMGFGPEMKKLISCPGMPSKEQRQTLLFSATFPEEIQRLAGDFLKSSYLFVAVGQVGGACRDVQQTILQVGQYSKREKLVEILRNIGDERTMVFVETKKKADFIATFLCQEKISTTSIHGDREQREREQALGDFRCGKCPVLVATSVAARGLDIENVQHVINFDLPSTIDEYVHRIGRTGRCGNTGRAISFFDTDSDNHLAQPLVKVLSDAQQDVPAWLEEIAFSTYVPPSFSSSTRGGAVFASVDTRKNYQGKHTLNTAGISSSQAPNPVDDESWD
uniprot
proteins
ec_number
3.6.4.13
uniprot
proteins
function
FUNCTION: ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and preventing their mobilization, which is essential for the germline integrity (PubMed:20439430, PubMed:28633017). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:20439430, PubMed:28633017). Involved in the secondary piRNAs metabolic process, the production of piRNAs in fetal male germ cells through a ping-pong amplification cycle (PubMed:20439430, PubMed:28633017). Required for PIWIL2 slicing-triggered piRNA biogenesis: helicase activity enables utilization of one of the slice cleavage fragments generated by PIWIL2 and processing these pre-piRNAs into piRNAs (PubMed:28633017). {ECO:0000269|PubMed:20439430, ECO:0000269|PubMed:28633017}.
uniprot
proteins
mass_dalton
76470
uniprot
proteins
mutagenesis
MUTAGEN 446; /note="E->Q: In Mvh(KI); heterozygous and homozygous knockin male mice are infertile due to derepression of transposable elements. Defects in piRNA biogenesis. Pre-piRNAs fail to mature into piRNAs."; /evidence="ECO:0000269|PubMed:28633017
uniprot
proteins
protein_family
DDX4/VASA subfamily
uniprot
proteins
protein_family
DEAD box helicase family
uniprot
proteins
pubmed
14648869
uniprot
proteins
pubmed
14736746
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
16787967
uniprot
proteins
pubmed
17141210
uniprot
proteins
pubmed
20439430
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22900038
uniprot
proteins
pubmed
27622290
uniprot
proteins
pubmed
28254886
uniprot
proteins
pubmed
28633017
uniprot
proteins
pubmed
36001654
uniprot
proteins
pubmed
7991615
uniprot
proteins
sequence_length
702
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:20439430, ECO:0000269|PubMed:22900038}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:22900038}. Note=Component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000269|PubMed:20439430}.
uniprot
proteins