F1M5M3
uniprot
F1M5M3
canonical
amino_acid_sequence
MSRAVHFPVPCPVLLGTLTDDSLEAQLHEYAKQGNYVKVKKILKKGVCVDAVNTLGQSALFVAALLGYVKLVDVLVDYGSDPNHRCFDGSTPVHAAAFSGNQWILSKVLTAGGDLRLHDEKGRNPQAWALAAGKDRSTQMVEFMQRCASHMKAVIQGFSYDLLKKIDSPQRLIGSPPWFGGLIQGSPNSSPNRQPKPGIISAQNIYSFGFGKFYLTSGMQLTYPGSLPVIGEKEVIQADDEPTFSFFSGPYMVMTNLVWNRSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSNLRHPSLLQLMAVCLSRDLEKIRLVYERITVGTLFSVLHERRSQFPVLHMEMIVHLLLQIADALIYLHSRGFIHRSLSSYAVHIVSAGEARLTNLEYMMESQDSGAHRDMTRVPLPAQLYNWAAPEVVLQKTATVKSDIYSFSMIIQEILTDNIPWNGLDGSLVKETIALGNYLEADVRLPEPYYDIVKSGIHAKQKNRTMNLQDIRYILKNDLKEFIGAQKTQTTESPRGQRYEPHPDINICLGLTSEYQKDPPDLDIKELKETGSQPHSPTDHSFLTEKTLAPQTLDSSLSAQEPDNPNVPSASRLAEEVRSPTPSEASLYSFEINEIYSGCLTLGTDKEEECPGTASSPEGDKANQVDELPSLEEELDKMERELHCFCEEDKSFSDVDTDLSFEDGDWQSDSLSSLSLPEPTREAKGKTSSWSKTDEYVSKCVLNLKISQVMMQQSAEWLRKLEQEVDELEWAQKELDNQCRSLWDASLRFANTKFLSAVGPPSLTYLPPVMQLSEPKQPENGGNWLTLARPPGNERDFQEGNFSKKSEKLSACDWNPFTQASEESRGYCSEPNNQPPTLCGPGKQNTGEQLPSTEEAKESLERNTNQNIRRMESVSSEVCDTKSRNNEDAGEARSKWRLAVKEMAEKAVSGQLLVPPWNLQSSFESKVENESTPLPRPPIRGPESTDWQYILEYQREKDELKGNMKFGKMENSDCDKNKHSSWTGLQRFTSIIYPFFRNHEQPEHNEASQASCDTXCGEKFYSTSSPIEDDFERIQSSFAQPQGYVEENFQIREIFGKNAEILTKPQFQAVQCAEDEQEETLEETPKELKEKNISLTDIQDLSSITYEQDGCFKETSCKTPKLKHAPTSASTPLSPESISSAASHYEDCLENTFHVKRGSTFCWNGQEAMRTLSTKFTTVRERAKSLESLLASSKTLPAKLTDPKRLCMFGGACSSNISTAFVTSTHSTKRKSLPGELAEATSQHHIDELPPPAQELLDEIEQLKQQQVSSMVSLENTAHDLNVTENDKKHLEEQETNSSKDSSFLSSREIQDLEDTERAHSSLDEDLERLLQLPEENMTLLDPTKGSTREKKTKDQDMVEQKRKKKEGIKPERRKSDSFLGTLEEDELKPCFWKRLGWSEPSRIIVLDQSDLSD
uniprot
proteins
function
FUNCTION: Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
162407
uniprot
proteins
post_translational_modification
PTM: Phosphorylated on Thr residues by CDK1 during early phases of mitosis, promoting the interaction with PLK1 and recruitment to kinetochores. Phosphorylated on Ser-431 by PLK1 during late prometaphase promotes the rapid depletion from kinetochores and its subsequent degradation by the APC/C complex.
uniprot
proteins
protein_family
Protein kinase superfamily
uniprot
proteins
pubmed
15057822
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
1443
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Midbody {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Note=Detected in the intercellular bridges that connect male germ cell daughter cells after cell division. {ECO:0000250}.
uniprot
proteins