NRG4
entrez
145957
canonical
uniprot
Q8WWG1
canonical
ensembl
ENSG00000169752
resolver
ensp
ENSP00000378367
resolver
ensp
ENSP00000455167
resolver
ensp
ENSP00000457335
resolver
ensp
ENSP00000525862
resolver
enst
ENST00000394907
resolver
enst
ENST00000566417
resolver
enst
ENST00000855803
resolver
genesymbol
NRG4
resolver
hgnc
HGNC:29862
resolver
uniprot
A6NIE8
resolver
uniprot_entry
NRG4_HUMAN
resolver
uniprot_sec
A6NIE8
resolver
amino_acid_sequence
MPTDHEEPCGPSHKSFCLNGGLCYVIPTIPSPFCRCVENYTGARCEEVFLPGSSIQTKSNLFEAFVALAVLVTLIIGAFYFLCRKGHFQRASSVQYDINLVETSSTSAHHSHEQH
uniprot
proteins
function
FUNCTION: Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
12722
uniprot
proteins
post_translational_modification
PTM: Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form. {ECO:0000250}.; PTM: Extensive glycosylation precedes the proteolytic cleavage. {ECO:0000250}.
uniprot
proteins
protein_family
Neuregulin family
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16572171
uniprot
proteins
sequence_length
115
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Pro-neuregulin-4, membrane-bound isoform]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Does not seem to be active. {ECO:0000250}.; SUBCELLULAR LOCATION: [Neuregulin-4]: Secreted {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 63..83; /note="Helical; Note=Internal signal sequence"; /evidence="ECO:0000255
uniprot
proteins