HCRTR1
entrez
3061
canonical
uniprot
O43613
canonical
ensembl
ENSG00000121764
resolver
ensp
ENSP00000362809
resolver
ensp
ENSP00000362810
resolver
ensp
ENSP00000384387
resolver
ensp
ENSP00000641662
resolver
ensp
ENSP00000641663
resolver
enst
ENST00000373705
resolver
enst
ENST00000373706
resolver
enst
ENST00000403528
resolver
enst
ENST00000971603
resolver
enst
ENST00000971604
resolver
genesymbol
HCRTR1
resolver
genesymbol_syn
ORXR1
resolver
genesymbol_syn
OX1R
resolver
genesymbol_syn
OXR1
resolver
hgnc
HGNC:4848
resolver
uniprot
A6NMV7
resolver
uniprot
A8K3A6
resolver
uniprot
Q9HBV6
resolver
uniprot_entry
A6NMV7_HUMAN
resolver
uniprot_entry
OX1R_HUMAN
resolver
uniprot_sec
A8K3A6
resolver
uniprot_sec
Q9HBV6
resolver
amino_acid_sequence
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
uniprot
proteins
function
FUNCTION: G protein-coupled receptor that binds the neuropeptide orexin-A with high affinity, and orexin-B with lower affinity, two peptides derived from a common precursor, prepro-orexin (PubMed:32669442, PubMed:9491897). Its activity is mediated via a G(q)-protein-coupled pathway, which activates the phosphatidylinositol-calcium second messenger system in response to orexin-A binding (PubMed:32669442). In addition to G(q)-mediated signaling, orexin-A stimulation also promotes beta-arrestin recruitment, leading to receptor internalization (PubMed:15683363, PubMed:32669442). Plays a significant role in the regulation of food intake (By similarity). {ECO:0000250|UniProtKB:P56718, ECO:0000269|PubMed:15683363, ECO:0000269|PubMed:32669442, ECO:0000269|PubMed:9491897}.
uniprot
proteins
mass_dalton
47536
uniprot
proteins
mutagenesis
MUTAGEN 26..41; /note="Missing: Abolishes response to orexin-A."; /evidence="ECO:0000269|PubMed:26950369"; MUTAGEN 36; /note="W->A: Strongly impairs response to orexin-A."; /evidence="ECO:0000269|PubMed:26950369"; MUTAGEN 127; /note="A->T: Confers EMPA binding. Decreases affinity for the selective ligand JH112. The affinity of antagonist suvorexant is slightly reduced."; /evidence="ECO:0000269|PubMed:31860301, ECO:0000269|PubMed:32669442"; MUTAGEN 318; /note="N->A: Strongly impairs response to orexin-A."; /evidence="ECO:0000269|PubMed:26950369
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10973318
uniprot
proteins
pubmed
11723285
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15683363
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
26950369
uniprot
proteins
pubmed
31860301
uniprot
proteins
pubmed
32669442
uniprot
proteins
pubmed
9491897
uniprot
proteins
sequence_length
425
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26950369, ECO:0000269|PubMed:9491897}; Multi-pass membrane protein {ECO:0000269|PubMed:26950369}.
uniprot
proteins
transmembrane_region
TRANSMEM 47..67; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:26950369"; TRANSMEM 83..105; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:26950369"; TRANSMEM 120..140; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:26950369"; TRANSMEM 161..182; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:26950369"; TRANSMEM 214..235; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:26950369"; TRANSMEM 299..321; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:26950369"; TRANSMEM 337..360; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:26950369
uniprot
proteins