Anapc15
entrez
293155
canonical
uniprot
D3ZQX4
canonical
ensembl
ENSRNOG00000019936
resolver
ensembl
ENSRNOG00055028754
resolver
ensembl
ENSRNOG00060003166
resolver
ensembl
ENSRNOG00065022785
resolver
ensp
ENSRNOP00000091579
resolver
genesymbol
Anapc15
resolver
uniprot
D4ACX3
resolver
uniprot_entry
APC15_RAT
resolver
uniprot_sec
D4ACX3
resolver
amino_acid_sequence
MEPGLKLSLGAMSTLFPSLFPRVTETLWFNLDRPCVEETELQQQEQQHQAWLQSIAEKDNNLVPIGKPASEHYDDEEEEDDEDDEDSEEDSEDDEDMQDMDEMNDYNESPDDGEVNEVDMEGNEQDQDQWMI
uniprot
proteins
function
FUNCTION: Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through the cell cycle (By similarity). APC/C acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). APC/C catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins (By similarity). APC/C is activated by CDC20 in the metaphase/anaphase transition of cell cycle, targeting the degradation of cyclin B and securin (By similarity). APC/C is regulated by the mitotic checkpoint complex (MCC), which inhibits APC/C and delays chromosome segregation (By similarity). Also required for degradation of CDC20 (By similarity). {ECO:0000250|UniProtKB:P60006}.
uniprot
proteins
mass_dalton
15378
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination. {ECO:0000250|UniProtKB:P60006}.
uniprot
proteins
protein_family
APC15 family
uniprot
proteins
pubmed
15057822
uniprot
proteins
sequence_length
132
uniprot
proteins