Lrrc19
entrez
100061
canonical
uniprot
Q8BZT5
canonical
ensembl
ENSMUSG00000049799
resolver
ensp
ENSMUSP00000056094
resolver
ensp
ENSMUSP00000102718
resolver
enst
ENSMUST00000053419
resolver
enst
ENSMUST00000107101
resolver
genesymbol
Lrrc19
resolver
uniprot
B1AWG3
resolver
uniprot
Q6P8J1
resolver
uniprot_entry
LRC19_MOUSE
resolver
uniprot_sec
B1AWG3
resolver
uniprot_sec
Q6P8J1
resolver
activity_regulation
ACTIVITY REGULATION: Activated by TLR ligands such as LPS, bacterial DNA and peptidoglycan. {ECO:0000269|PubMed:19679103}.
uniprot
proteins
amino_acid_sequence
MKVTRFMFWLFSMLLPSVKSQASETEVPCNFSRRNYTLIPEGISTNVTILDLSYNRITLNAADSRVLQMYSLLTELYLMENNIIALYNSSFRNLLNLEILNICGNSISVIQQGSFVGLNELKQLFLCQNKILQLNPDTFVPLNNLKVLNLQGNLIRLFDAPQLPHLEILTLDGNPWNCTCGLLELHNWLNTSNVTLENENMTMCSYPDELKHDSIKSAPFTTECHSTFISTITEDFQSTRNSSFNSSSHNLTWTSEHEPLGKSWAFLVGVVATVLLTSLLIFIAIKCPVWYNILLSYNHHRLEEHEAETYENGLTRNPSSLSQITDTNSEDTTVIFEQLHAFVVDDDGFIEDRYIDINEVHEEK
uniprot
proteins
function
FUNCTION: Pathogen-recognition receptor which mediates the activation of TRAF2- and TRAF6 NF-kappa-B signaling pathways and induces the expression of pro-inflammatory cytokines (PubMed:19679103, PubMed:25026888, PubMed:26776522). In kidney, prevents infection by uropathogenic bacteria by inducing the production of cytokines, chemokines and antimicrobial substances (PubMed:25026888). In gut, involved in host-microbiota interactions, plays a critical role in promoting the recruitment of immune cells and intestinal inflammation (PubMed:26776522). {ECO:0000269|PubMed:19679103, ECO:0000269|PubMed:25026888, ECO:0000269|PubMed:26776522}.
uniprot
proteins
mass_dalton
41573
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
19679103
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
25026888
uniprot
proteins
pubmed
26776522
uniprot
proteins
sequence_length
364
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
uniprot
proteins
transmembrane_region
TRANSMEM 265..285; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins