Abcb1a
entrez
18671
canonical
uniprot
P21447
canonical
ensembl
ENSMUSG00000040584
resolver
ensp
ENSMUSP00000041204
resolver
enst
ENSMUST00000047753
resolver
genesymbol
Abcb1a
resolver
genesymbol_syn
Abcb4
resolver
genesymbol_syn
Mdr1a
resolver
genesymbol_syn
Mdr3
resolver
genesymbol_syn
Pgy-3
resolver
genesymbol_syn
Pgy3
resolver
uniprot
Q5I1Y5
resolver
uniprot_entry
MDR1A_MOUSE
resolver
uniprot_sec
Q5I1Y5
resolver
activity_regulation
ACTIVITY REGULATION: Translocase activity is inhibited by verapamil and is sensitive to energy depletion. C1orf115 regulates drug efflux through modulation of ABCB1 localization and activity. {ECO:0000250|UniProtKB:P08183}.
uniprot
proteins
amino_acid_sequence
MELEEDLKGRADKNFSKMGKKSKKEKKEKKPAVSVLTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLIFGDMTDSFASVGNVSKNSTNMSEADKRAMFAKLEEEMTTYAYYYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQAMATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKILSSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWYGTSLVISKEYSIGQVLTVFFSVLIGAFSVGQASPNIEAFANARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNLEFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGVVSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTAGNEIELGNEACKSKDEIDNLDMSSKDSGSSLIRRRSTRKSICGPHDQDRKLSTKEALDEDVPPASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFSKVVGVFTNGGPPETQRQNSNLFSLLFLILGIISFITFFLQGFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMKKAHVFGITFSFTQAMMYFSYAACFRFGAYLVTQQLMTFENVLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIRIIEKTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYPTRPSIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGSVFLDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQKGIYFSMVSVQAGAKRS
uniprot
proteins
ec_number
7.6.2.1
uniprot
proteins
ec_number
7.6.2.2
uniprot
proteins
function
FUNCTION: Translocates phospholipids and drugs across the membrane. Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (By similarity). May contribute to hepatobiliary and renal excretion of etiocholanolone-3-glucuronate. Appears to have very low activity toward testosterone, androsterone and dihydrotestosterone glucuronates. {ECO:0000250|UniProtKB:P08183, ECO:0000269|PubMed:8898203}.
uniprot
proteins
mass_dalton
140647
uniprot
proteins
protein_family
ABC transporter superfamily
uniprot
proteins
protein_family
ABCB family
uniprot
proteins
protein_family
Multidrug resistance exporter (TC 3.A.1.201) subfamily
uniprot
proteins
pubmed
19325113
uniprot
proteins
pubmed
1969610
uniprot
proteins
pubmed
1972547
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
2473069
uniprot
proteins
pubmed
8898203
uniprot
proteins
sequence_length
1276
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P08183}; Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}. Apical cell membrane {ECO:0000269|PubMed:8898203}. Cytoplasm {ECO:0000250|UniProtKB:P08183}. Note=ABCB1 localization is influenced by C1orf115 expression levels (plasma membrane versus cytoplasm). {ECO:0000250|UniProtKB:P08183}.
uniprot
proteins
transmembrane_region
TRANSMEM 44..66; /note="Helical"; TRANSMEM 113..133; /note="Helical"; TRANSMEM 183..204; /note="Helical"; TRANSMEM 212..232; /note="Helical"; TRANSMEM 291..312; /note="Helical"; TRANSMEM 327..348; /note="Helical"; TRANSMEM 708..728; /note="Helical"; TRANSMEM 753..773; /note="Helical"; TRANSMEM 829..849; /note="Helical"; TRANSMEM 851..870; /note="Helical"; TRANSMEM 931..953; /note="Helical"; TRANSMEM 970..991; /note="Helical
uniprot
proteins