Lgr6
entrez
329252
canonical
uniprot
Q3UVD5
canonical
ensembl
ENSMUSG00000042793
resolver
ensp
ENSMUSP00000035444
resolver
ensp
ENSMUSP00000122334
resolver
ensp
ENSMUSP00000264784
resolver
ensp
ENSMUSP00000264785
resolver
enst
ENSMUST00000044828
resolver
enst
ENSMUST00000137968
resolver
genesymbol
Lgr6
resolver
uniprot
B2RUL8
resolver
uniprot
D3Z6S4
resolver
uniprot
Q80UB8
resolver
uniprot
Q8R301
resolver
uniprot_entry
D3Z6S4_MOUSE
resolver
uniprot_entry
LGR6_MOUSE
resolver
uniprot_sec
B2RUL8
resolver
uniprot_sec
Q80UB8
resolver
uniprot_sec
Q8R301
resolver
amino_acid_sequence
MHSPPGLLALWLCAVLCASARAGSDPQPGPGRPACPAPCHCQEDGIMLSADCSELGLSVVPADLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLHSLKILMLQSNQLRGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNHIRHIPDYAFQNLTSLVVLHLHNNRIQHVGTHSFEGLHNLETLDLNYNELQEFPLAIRTLGRLQELGFHNNNIKAIPEKAFMGSPLLQTIHFYDNPIQFVGRSAFQYLSKLHTLSLNGATDIQEFPDLKGTTSLEILTLTRAGIRLLPPGVCQQLPRLRILELSHNQIEELPSLHRCQKLEEIGLRHNRIKEIGADTFSQLGSLQALDLSWNAIRAIHPEAFSTLRSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCAYGICASFFKTSGQWQAEDFHPEEEEAPKRPLGLLAGQAENHYDLDLDELQMGTEDSKPHPSVQCSPVPGPFKPCEHLFESWGIRLAVWAIVLLSVLCNGLVLLTVFASGPSPLSPVKLVVGAMAGANALSGISCGLLASVDALTYGQFAEYGARWESGLGCQATGFLAVLGSEASVLLLTLAAVQCSISVTCVRAYGKAPSPGSVRAGALGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGRPAALGFAVALVMMNSLCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLWPSPRSPGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGQPPGLETYGFPSVTLISRHQPGATRLEGNHFVESDGTKFGNPQPPMKGELLLKAEGATLAGCGSSVGGALWPSGSLFASHL
uniprot
proteins
function
FUNCTION: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G protein-coupled receptors, does not activate heterotrimeric G proteins to transduce the signal (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
104267
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
12679517
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
20223988
uniprot
proteins
pubmed
29769720
uniprot
proteins
sequence_length
967
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
uniprot
proteins
transmembrane_region
TRANSMEM 568..588; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 599..619; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 645..665; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 688..708; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 728..748; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 775..795; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 810..830; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins