NSD3
entrez
54904
canonical
uniprot
Q9BZ95
canonical
ensembl
ENSG00000147548
resolver
ensp
ENSP00000313410
resolver
ensp
ENSP00000313983
resolver
genesymbol
NSD3
resolver
genesymbol_syn
WHSC1L1
resolver
hgnc
HGNC:12767
resolver
uniprot
B7ZL11
resolver
uniprot
D3DSX1
resolver
uniprot
Q1RMD3
resolver
uniprot
Q3B796
resolver
uniprot
Q6ZSA5
resolver
uniprot
Q9BYU8
resolver
uniprot
Q9BYU9
resolver
uniprot
Q9H2M8
resolver
uniprot
Q9H9W9
resolver
uniprot
Q9NXA6
resolver
uniprot_entry
NSD3_HUMAN
resolver
uniprot_sec
B7ZL11
resolver
uniprot_sec
D3DSX1
resolver
uniprot_sec
Q1RMD3
resolver
uniprot_sec
Q3B796
resolver
uniprot_sec
Q6ZSA5
resolver
uniprot_sec
Q9BYU8
resolver
uniprot_sec
Q9BYU9
resolver
uniprot_sec
Q9H2M8
resolver
uniprot_sec
Q9H9W9
resolver
uniprot_sec
Q9NXA6
resolver
amino_acid_sequence
MDFSFSFMQGIMGNTIQQPPQLIDSANIRQEDAFDNNSDIAEDGGQTPYEATLQQGFQYPATTEDLPPLTNGYPSSISVYETQTKYQSYNQYPNGSANGFGAVRNFSPTDYYHSEIPNTRPHEILEKPSPPQPPPPPSVPQTVIPKKTGSPEIKLKITKTIQNGRELFESSLCGDLLNEVQASEHTKSKHESRKEKRKKSNKHDSSRSEERKSHKIPKLEPEEQNRPNERVDTVSEKPREEPVLKEEAPVQPILSSVPTTEVSTGVKFQVGDLVWSKVGTYPWWPCMVSSDPQLEVHTKINTRGAREYHVQFFSNQPERAWVHEKRVREYKGHKQYEELLAEATKQASNHSEKQKIRKPRPQRERAQWDIGIAHAEKALKMTREERIEQYTFIYIDKQPEEALSQAKKSVASKTEVKKTRRPRSVLNTQPEQTNAGEVASSLSSTEIRRHSQRRHTSAEEEEPPPVKIAWKTAAARKSLPASITMHKGSLDLQKCNMSPVVKIEQVFALQNATGDGKFIDQFVYSTKGIGNKTEISVRGQDRLIISTPNQRNEKPTQSVSSPEATSGSTGSVEKKQQRRSIRTRSESEKSTEVVPKKKIKKEQVETVPQATVKTGLQKGASEISDSCKPLKKRSRASTDVEMTSSAYRDTSDSDSRGLSDLQVGFGKQVDSPSATADADVSDVQSMDSSLSRRGTGMSKKDTVCQICESSGDSLIPCEGECCKHFHLECLGLASLPDSKFICMECKTGQHPCFSCKVSGKDVKRCSVGACGKFYHEACVRKFPTAIFESKGFRCPQHCCSACSMEKDIHKASKGRMMRCLRCPVAYHSGDACIAAGSMLVSSYILICSNHSKRSSNSSAVNVGFCFVCARGLIVQDHSDPMFSSYAYKSHYLLNESNRAELMKLPMIPSSSASKKKCEKGGRLLCCESCPASFHPECLSIEMPEGCWNCNDCKAGKKLHYKQIVWVKLGNYRWWPAEICNPRSVPLNIQGLKHDLGDFPVFFFGSHDYYWVHQGRVFPYVEGDKSFAEGQTSINKTFKKALEEAAKRFQELKAQRESKEALEIEKNSRKPPPYKHIKANKVIGKVQIQVADLSEIPRCNCKPADENPCGLESECLNRMLQYECHPQVCPAGDRCQNQCFTKRLYPDAEIIKTERRGWGLRTKRSIKKGEFVNEYVGELIDEEECRLRIKRAHENSVTNFYMLTVTKDRIIDAGPKGNYSRFMNHSCNPNCETQKWTVNGDVRVGLFALCDIPAGMELTFNYNLDCLGNGRTECHCGADNCSGFLGVRPKSACASTNEEKAKNAKLKQKRRKIKTEPKQMHEDYCFQCGDGGELVMCDKKDCPKAYHLLCLNLTQPPYGKWECPWHQCDECSSAAVSFCEFCPHSFCKDHEKGALVPSALEGRLCCSEHDPMAPVSPEYWSKIKCKWESQDHGEEVKE
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in NSD3 may be involved in non small cell lung carcinomas (NSCLC). Amplified or overexpressed in NSCLC. {ECO:0000269|PubMed:15983384}.; DISEASE: Note=A chromosomal aberration involving NSD3 is found in childhood acute myeloid leukemia. Translocation t(8;11)(p11.2;p15) with NUP98. {ECO:0000269|PubMed:11986249}.
uniprot
proteins
ec_number
2.1.1.370
uniprot
proteins
ec_number
2.1.1.371
uniprot
proteins
function
FUNCTION: Histone methyltransferase. Preferentially dimethylates 'Lys-4' and 'Lys-27' of histone H3 forming H3K4me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. {ECO:0000269|PubMed:16682010}.
uniprot
proteins
mass_dalton
161613
uniprot
proteins
protein_family
Class V-like SAM-binding methyltransferase superfamily
uniprot
proteins
protein_family
Histone-lysine methyltransferase family
uniprot
proteins
protein_family
SET2 subfamily
uniprot
proteins
pubmed
11374904
uniprot
proteins
pubmed
11549311
uniprot
proteins
pubmed
11986249
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15983384
uniprot
proteins
pubmed
16421571
uniprot
proteins
pubmed
16682010
uniprot
proteins
pubmed
19608861
uniprot
proteins
pubmed
21406692
uniprot
proteins
pubmed
21555454
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
25218447
uniprot
proteins
pubmed
25755297
uniprot
proteins
pubmed
25772364
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
29176719
uniprot
proteins
pubmed
29567837
uniprot
proteins
pubmed
33592170
uniprot
proteins
sequence_length
1437
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
uniprot
proteins