OPTC
entrez
26254
canonical
uniprot
Q9UBM4
canonical
ensembl
ENSG00000188770
resolver
ensp
ENSP00000356191
resolver
ensp
ENSP00000520429
resolver
enst
ENST00000367222
resolver
enst
ENST00000715259
resolver
genesymbol
OPTC
resolver
genesymbol_syn
OPT
resolver
hgnc
HGNC:8158
resolver
uniprot
Q5T2G4
resolver
uniprot_entry
OPT_HUMAN
resolver
uniprot_sec
Q5T2G4
resolver
amino_acid_sequence
MRLLAFLSLLALVLQETGTASLPRKERKRREEQMPREGDSFEVLPLRNDVLNPDNYGEVIDLSNYEELTDYGDQLPEVKVTSLAPATSISPAKSTTAPGTPSSNPTMTRPTTAGLLLSSQPNHGLPTCLVCVCLGSSVYCDDIDLEDIPPLPRRTAYLYARFNRISRIRAEDFKGLTKLKRIDLSNNLISSIDNDAFRLLHALQDLILPENQLEALPVLPSGIEFLDVRLNRLQSSGIQPAAFRAMEKLQFLYLSDNLLDSIPGPLPLSLRSVHLQNNLIETMQRDVFCDPEEHKHTRRQLEDIRLDGNPINLSLFPSAYFCLPRLPIGRFT
uniprot
proteins
function
FUNCTION: Inhibits angiogenesis in the vitreous humor of the eye, and therefore represses neovascularization (By similarity). Binds collagen fibrils (By similarity). May be involved in collagen fiber organization via regulation of other members of the small leucine-rich repeat proteoglycan superfamily (By similarity). {ECO:0000250|UniProtKB:P58874, ECO:0000250|UniProtKB:Q920A0}.
uniprot
proteins
mass_dalton
37261
uniprot
proteins
post_translational_modification
PTM: O-glycosylated. {ECO:0000305|PubMed:16335952}.; PTM: Proteolytically cleaved by MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, ADAMTS4, and ADAMTS5 (PubMed:23845380). Proteolytically cleaved by MMP13 (By similarity). The degradation of OPTC by proteases may contribute to osteoarthritis pathophysiology (PubMed:23845380). {ECO:0000250|UniProtKB:P58874, ECO:0000269|PubMed:23845380}.; PTM: Sulfated on tyrosine residues. {ECO:0000269|PubMed:25136834}.
uniprot
proteins
protein_family
SLRP class III subfamily
uniprot
proteins
protein_family
Small leucine-rich proteoglycan (SLRP) family
uniprot
proteins
pubmed
10636917
uniprot
proteins
pubmed
10837509
uniprot
proteins
pubmed
10892843
uniprot
proteins
pubmed
12019215
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16335952
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
18164633
uniprot
proteins
pubmed
23845380
uniprot
proteins
pubmed
25136834
uniprot
proteins
sequence_length
332
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:18164633}.
uniprot
proteins