Pla1a
entrez
85311
canonical
uniprot
P97535
canonical
ensembl
ENSRNOG00000057153
resolver
ensembl
ENSRNOG00055016283
resolver
ensembl
ENSRNOG00060007899
resolver
ensembl
ENSRNOG00065019164
resolver
ensp
ENSRNOP00000071860
resolver
ensp
ENSRNOP00055022152
resolver
ensp
ENSRNOP00060009877
resolver
ensp
ENSRNOP00065025734
resolver
enst
ENSRNOT00000077727
resolver
enst
ENSRNOT00055027609
resolver
enst
ENSRNOT00060013018
resolver
enst
ENSRNOT00065032226
resolver
genesymbol
Pla1a
resolver
genesymbol_syn
Pspla1
resolver
uniprot_entry
PLA1A_RAT
resolver
amino_acid_sequence
MCPGLWGTCFWLWGSLLWLSIGRSGNVPPTTQPKCTDFQSANLLRGTNLKVQFLLFTPSDPGCGQLVEEDSDIRNSEFNASLGTKLIIHGFRALGTKPSWINKFIRALLRAADANVIAVDWVYGSTGMYFSAVENVVKLSLEISRFLSKLLELGVSESSIHIIGVSLGAHVGGMVGHFYKGQLGRITGLDPAGPEYTRASLEERLDSGDALFVEAIHTDTDNLGIRIPVGHVDYFVNGGQDQPGCPAFIHAGYSYLICDHMRAVHLYISALENTCPLMAFPCASYKAFLAGDCLDCFNPFLLSCPRIGLVERGGVKIEPLPKEVRVYLQTTSSAPYCVHHSLVEFNLKEKRKKDTSIEVTFLGNNVTSSVKITIPKDHLEGRGIIAHQNPHCQINQVKLKFHISSRVWRKDRTPIVGTFCTAPLPVNDSKKTVCIPEPVRLQVSMAVLRDLKMACV
uniprot
proteins
ec_number
3.1.1.111
uniprot
proteins
function
FUNCTION: Hydrolyzes the ester bond of the acyl group attached at the sn-1 position of phosphatidylserines (phospholipase A1 activity) and 1-acyl-2-lysophosphatidylserines (lysophospholipase activity) in the pathway of phosphatidylserines acyl chain remodeling (PubMed:8999922). Cleaves phosphatidylserines exposed on the outer leaflet of the plasma membrane of apoptotic cells producing 2-acyl-1-lysophosphatidylserines, which in turn enhance mast cell activation and histamine production (PubMed:11395520). Has no activity toward other glycerophospholipids including phosphatidylcholines, phosphatidylethanolamines, phosphatidic acids or phosphatidylinositols, or glycerolipids such as triolein (PubMed:8999922). {ECO:0000269|PubMed:11395520, ECO:0000269|PubMed:8999922}.
uniprot
proteins
mass_dalton
50202
uniprot
proteins
protein_family
AB hydrolase superfamily
uniprot
proteins
protein_family
Lipase family
uniprot
proteins
pubmed
11395520
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
8999922
uniprot
proteins
sequence_length
456
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:8999922}.
uniprot
proteins