Awat2
entrez
245532
canonical
uniprot
Q6E1M8
canonical
ensembl
ENSMUSG00000031220
resolver
ensp
ENSMUSP00000033567
resolver
ensp
ENSMUSP00000128516
resolver
genesymbol
Awat2
resolver
genesymbol_syn
Dgat2l4
resolver
genesymbol_syn
Ws
resolver
uniprot
A2ADU0
resolver
uniprot
Q8BM49
resolver
uniprot_entry
A2ADU0_MOUSE
resolver
uniprot_entry
AWAT2_MOUSE
resolver
uniprot_sec
Q8BM49
resolver
activity_regulation
ACTIVITY REGULATION: 11-cis retinoids act as allosteric modulators of acyl-CoA retinol O-fatty-acyltransferase (ARAT) activity by suppressing esterification of 9-cis, 13-cis, or all-trans retinols concurrently increasing the enzyme specificity toward 11-cis isomer. {ECO:0000269|PubMed:28096191}.
uniprot
proteins
amino_acid_sequence
MFWPTKKDLKTAMEVFALFQWALSALVIVTTVIIVNLYLVVFTSYWPVTVLMLTWLAFDWKTPERGGRRFTCVRKWRLWKHYSDYFPLKMVKTKDISPDRNYILVCHPHGLMAHSCFGHFATDTTGFSKTFPGITPYMLTLGAFFWVPFLRDYVMSTGSCSVSRSSMDFLLTQKGTGNMLVVVVGGLAECRYSTPGSTTLFLKKRQGFVRTALKHGVSLIPAYAFGETDLYDQHIFTPGGFVNRFQKWFQKMVHIYPCAFYGRGLTKNSWGLLPYSQPVTTVVGEPLPLPKIENPSEEIVAKYHTLYIDALRKLFDQHKTKFGISETQELVIV
uniprot
proteins
ec_number
2.3.1.20
uniprot
proteins
ec_number
2.3.1.75
uniprot
proteins
ec_number
2.3.1.76
uniprot
proteins
function
FUNCTION: Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters (PubMed:15220349). Shows a preference for medium chain acyl-CoAs from C12 to C16 in length and fatty alcohols shorter than C20, as the acyl donor and acceptor, respectively (PubMed:15220349). Also possesses fatty acyl-CoA retinol acyltransferase (ARAT) activity that preferentially esterifies 11-cis-retinol, a chromophore precursor of bleached opsin pigments in cone cells (PubMed:28096191). Shows higher catalytic efficiency toward 11-cis-retinol versus 9-cis-retinol, 13- cis-retinol and all-trans-retinol substrates. {ECO:0000269|PubMed:15220349, ECO:0000269|PubMed:28096191}.
uniprot
proteins
mass_dalton
38145
uniprot
proteins
protein_family
Diacylglycerol acyltransferase family
uniprot
proteins
pubmed
15220349
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
24799687
uniprot
proteins
pubmed
28096191
uniprot
proteins
sequence_length
333
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000269|PubMed:15220349}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..35; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 38..58; /note="Helical"; /evidence="ECO:0000255"; TRANSMEM 130..150; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins