Cirsr
entrez
362149
canonical
uniprot
Q5U2T8
canonical
ensembl
ENSRNOG00000018719
resolver
ensp
ENSRNOP00000060978
resolver
enst
ENSRNOT00000064662
resolver
genesymbol
Cirsr
resolver
genesymbol_syn
Cir
resolver
genesymbol_syn
Cir1
resolver
uniprot_entry
CIR1_RAT
resolver
amino_acid_sequence
MGKSFANFMCKKDFHPASKSNIKKVWMAEQKISYDKKKQEELMQQYLKEQESYDNRLLMGDERVKNGLNFMYEAPPGVKKENKEKEETEGETEYKFEWQKGAPREKYAKDDMNIRDQPFGIQVRNVRCIKCHKWGHVNTDRECPLFGLSGINASSVPTDGSGPSMHPSELIAEMRNSGFALKRNVLGRNLTANDPSQDYVASDGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKKSDKKKKKLQKSKNKHKKHKKSSSSSSSSSSSSSSSSSSSSSSSSSSTSSSETDSSSESDNKEKKEKEKRKKRKKTKCSGNKSGDCKEYKSKNMLYEELSSSHSDRGKAQEKLRLLKQESSGENSTWVHSGSDRKSRSHQHSPERKGSDRNGGSRSRSRAEGSRRSRSRSPCGQKHREREARSRPHQSPSEEQKGRKGTRSHGDSEHRRERAR
uniprot
proteins
function
FUNCTION: May modulate splice site selection during alternative splicing of pre-mRNAs. Regulates transcription and acts as a corepressor for RBPJ. Recruits RBPJ to the Sin3-histone deacetylase complex (HDAC). Required for RBPJ-mediated repression of transcription (By similarity). {ECO:0000250}.
uniprot
proteins
mass_dalton
51416
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by NEK6. {ECO:0000250}.
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
22673903
uniprot
proteins
sequence_length
451
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000250|UniProtKB:Q9DA19}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:Q86X95}. Note=Colocalizes with NEK6 in the centrosome. {ECO:0000250|UniProtKB:Q86X95}.
uniprot
proteins