Nyx
entrez
236690
canonical
uniprot
P83503
canonical
ensembl
ENSMUSG00000051228
resolver
ensp
ENSMUSP00000056313
resolver
ensp
ENSMUSP00000271521
resolver
enst
ENSMUST00000050434
resolver
genesymbol
Nyx
resolver
uniprot
Q8BYN4
resolver
uniprot_entry
NYX_MOUSE
resolver
uniprot_sec
Q8BYN4
resolver
amino_acid_sequence
MLILLLHAVVFSLPYTRATEACLRACPAACTCSHVERGCSVRCDRAGLQRVPQEFPCEAASIDLDRNGLRILGERAFGTLPSLRRLSLRHNNLSFITPGAFKGLPRLAELRLAHNGELRYLHVRTFAALGRLRRLDLAACRLFSVPERLLAELPALRELTAFDNLFRRVPGALRGLANLTHAHFERSRIEAVASGSLLGMRRLRSLSLQANRVRAVHAGAFGDCGALEDLLLNDNLLATLPAAAFRGLRRLRTLNLGGNALGSVARAWFSDLAELELLYLDRNSITFVEEGAFQNLSGLLALHLNGNRLTVLSWAAFQPGFFLGRLFLFRNPWRCDCQLEWLRDWMEGSGRVADVACASPGSVAGQDLSQVVFERSSDGLCVDPDELNFTTSSPGPSPEPVATTVSRFSSLLSKLLAPRAPVEEVANTTWELVNVSLNDSFRSHAVMVFCYKATFLFTSCVLLSLAQYVVVGLQRE
uniprot
proteins
disease_involvement
DISEASE: Note=Defects in Nyx are the cause of the nob (no b-wave) phenotype which is characterized by a decreased sensitivity to light and an absence of the rod b-wave in electroretinograms. An 85-bp deletion in exon 3 results in the loss of 288 residues from the C-terminus of the protein. {ECO:0000269|PubMed:12506099}.
uniprot
proteins
function
FUNCTION: Required for normal vision. Is a critical factor for light-induced depolarization of retinal ON-bipolar cells, likely acting as a scaffold for TRPM1 and GRM6 (PubMed:21832182). Required for TRPM1 trafficking to dendritic tips of ON-bipolar cells (PubMed:21734298). {ECO:0000269|PubMed:17881478, ECO:0000269|PubMed:21734298, ECO:0000269|PubMed:21832182}.
uniprot
proteins
mass_dalton
52431
uniprot
proteins
protein_family
SLRP class IV subfamily
uniprot
proteins
protein_family
Small leucine-rich proteoglycan (SLRP) family
uniprot
proteins
pubmed
12506099
uniprot
proteins
pubmed
12714669
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
17881478
uniprot
proteins
pubmed
21734298
uniprot
proteins
pubmed
21832182
uniprot
proteins
sequence_length
476
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000250}. Cell projection, dendrite {ECO:0000269|PubMed:17881478, ECO:0000269|PubMed:21734298}. Postsynapse {ECO:0000269|PubMed:17881478}. Note=In the retina, localized postsynaptically at the dendritic tips of ON-bipolar cells. {ECO:0000269|PubMed:17881478, ECO:0000269|PubMed:21734298}.
uniprot
proteins