Slc13a5
entrez
266998
canonical
uniprot
Q8CJ44
canonical
ensembl
ENSRNOG00000014870
resolver
ensp
ENSRNOP00000020043
resolver
ensp
ENSRNOP00000090194
resolver
enst
ENSRNOT00000020043
resolver
genesymbol
Slc13a5
resolver
genesymbol_syn
Nact
resolver
uniprot
A0A0H2UHM2
resolver
uniprot_entry
A0A0H2UHM2_RAT
resolver
uniprot_entry
S13A5_RAT
resolver
activity_regulation
ACTIVITY REGULATION: Inhibited by Li(+). {ECO:0000269|PubMed:12826022}.
uniprot
proteins
amino_acid_sequence
MASAKTYVTKFKSFVILFFAPILLLPLIILVPDKFARCAYVIILMAIYWCTDVIPVAITSLLPVLLFPLLKVLDSKQVCVQYMTDTNMLFLGSLIVATAVERWELHKRIALRMLLFVGTKPSRLMLGFMFVTAFLSMWISNTATTAMMIPIVEAMLEQMVATNVAVDASQRTMELLDKNKASELPGSQVVFEDPSVQKQEDEETKNMYKAMNLCVCYAASIGGTATLTGTGPNVVLLGQMQELFPDSKDVMNFASWFAFALPNMLLMLVMAWLWLLCFYMRPNLKKTCICCGRKKKDTEKIASKVLYEEYRKLGPLSYAECNVLFCFGLLIILWFSRDPGFMPGWLSIAWIEGNTKHVTDATVAIFVAILLFIVPSQKPKFNFSRQTEEERKTPFYPPPLLNWKVTQEKVPWGIVLLLGGGFAMAKGCETSGLSEWMARQMEPLSSVRPAIITLILSCIVAMTTECTSNVATTTLFLPIFASMARSIGIHPLYVMIPCTLSASLAFMLPVATPPNAIVFAYGHLKVIDMVKTGLVMNILGIASVFLSVNTWGRAVFNLDKFPDWANLTHINT
uniprot
proteins
function
FUNCTION: High-affinity sodium/citrate cotransporter that mediates citrate entry into cells, which is a critical participant of biochemical pathways (PubMed:12177002, PubMed:12826022, PubMed:14656221). May function in various metabolic processes in which citrate has a critical role such as energy production (Krebs cycle), fatty acid synthesis, cholesterol synthesis, glycolysis, and gluconeogenesis (By similarity). Transports citrate into the cell in a Na(+)-dependent manner, recognizing the trivalent form of citrate (physiological pH) rather than the divalent form (PubMed:12177002, PubMed:12826022, PubMed:14656221). Can recognize succinate as a substrate, but its affinity for succinate is several fold lower than for citrate (PubMed:12177002, PubMed:14656221). The stoichiometry is probably 4 Na(+) for each carboxylate, irrespective of whether the translocated substrate is divalent or trivalent, rendering the process electrogenic (PubMed:12177002, PubMed:14656221). Involved in the regulation of citrate levels in the brain (By similarity). {ECO:0000250|UniProtKB:Q67BT3, ECO:0000250|UniProtKB:Q86YT5, ECO:0000269|PubMed:12177002, ECO:0000269|PubMed:12826022, ECO:0000269|PubMed:14656221}.
uniprot
proteins
mass_dalton
63878
uniprot
proteins
protein_family
NADC subfamily
uniprot
proteins
protein_family
SLC13A/DASS transporter (TC 2.A.47) family
uniprot
proteins
pubmed
12177002
uniprot
proteins
pubmed
12826022
uniprot
proteins
pubmed
14656221
uniprot
proteins
sequence_length
572
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q86YT5}; Multi-pass membrane protein {ECO:0000250|UniProtKB:Q86YT5}.
uniprot
proteins
transmembrane_region
TRANSMEM 15..28; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:Q86YT5"; TRANSMEM 34..49; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:Q86YT5"; TRANSMEM 56..69; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:Q86YT5"; TRANSMEM 75..117; /note="Discontinuously helical; Name=4"; /evidence="ECO:0000250|UniProtKB:Q86YT5"; TRANSMEM 206..243; /note="Discontinuously helical; Name=5"; /evidence="ECO:0000250|UniProtKB:Q86YT5"; TRANSMEM 253..279; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:Q86YT5"; TRANSMEM 319..336; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:Q86YT5"; TRANSMEM 360..372; /note="Helical; Name=8"; /evidence="ECO:0000250|UniProtKB:Q86YT5"; TRANSMEM 403..439; /note="Discontinuously helical; Name=9"; /evidence="ECO:0000250|UniProtKB:Q86YT5"; TRANSMEM 491..521; /note="Discontinuously helical; Name=10"; /evidence="ECO:0000250|UniProtKB:Q86YT5"; TRANSMEM 527..555; /note="Helical; Name=11"; /evidence="ECO:0000250|UniProtKB:Q86YT5
uniprot
proteins