SLC2A2
entrez
6514
canonical
uniprot
P11168
canonical
ensembl
ENSG00000163581
resolver
ensp
ENSP00000323568
resolver
genesymbol
SLC2A2
resolver
genesymbol_syn
GLUT2
resolver
hgnc
HGNC:11006
resolver
uniprot
A8K481
resolver
uniprot
B2R936
resolver
uniprot
B7Z547
resolver
uniprot
F8W8V8
resolver
uniprot
Q6PAU8
resolver
uniprot
Q9UCW9
resolver
uniprot_entry
GTR2_HUMAN
resolver
uniprot_entry
Q6PAU8_HUMAN
resolver
uniprot_sec
A8K481
resolver
uniprot_sec
B2R936
resolver
uniprot_sec
B7Z547
resolver
uniprot_sec
F8W8V8
resolver
uniprot_sec
Q9UCW9
resolver
activity_regulation
ACTIVITY REGULATION: D-glucose and maltose competitively inhibit fructose transport (PubMed:8457197). D-glucose, D-fructose and maltose inhibit deoxyglucose transport (PubMed:8457197). Glucose and fructose transport are inhibited by flavonoids such as epigallocatechin gallate, apigenin and quercetin (PubMed:29548810). {ECO:0000269|PubMed:29548810, ECO:0000269|PubMed:8457197}.
uniprot
proteins
amino_acid_sequence
MTEDKVTGTLVFTVITAVLGSFQFGYDIGVINAPQQVIISHYRHVLGVPLDDRKAINNYVINSTDELPTISYSMNPKPTPWAEEETVAAAQLITMLWSLSVSSFAVGGMTASFFGGWLGDTLGRIKAMLVANILSLVGALLMGFSKLGPSHILIIAGRSISGLYCGLISGLVPMYIGEIAPTALRGALGTFHQLAIVTGILISQIIGLEFILGNYDLWHILLGLSGVRAILQSLLLFFCPESPRYLYIKLDEEVKAKQSLKRLRGYDDVTKDINEMRKEREEASSEQKVSIIQLFTNSSYRQPILVALMLHVAQQFSGINGIFYYSTSIFQTAGISKPVYATIGVGAVNMVFTAVSVFLVEKAGRRSLFLIGMSGMFVCAIFMSVGLVLLNKFSWMSYVSMIAIFLFVSFFEIGPGPIPWFMVAEFFSQGPRPAALAIAAFSNWTCNFIVALCFQYIADFCGPYVFFLFAGVLLAFTLFTFFKVPETKGKSFEEIAAEFQKKSGSAHRPKAAVEMKFLGATETV
uniprot
proteins
disease_involvement
DISEASE: Fanconi-Bickel syndrome (FBS) [MIM:227810]: Rare, well-defined clinical entity, inherited in an autosomal recessive mode and characterized by hepatorenal glycogen accumulation, proximal renal tubular dysfunction, and impaired utilization of glucose and galactose. {ECO:0000269|PubMed:10987651, ECO:0000269|PubMed:11044475}. Note=The disease is caused by variants affecting the gene represented in this entry.
uniprot
proteins
function
FUNCTION: Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose (PubMed:16186102, PubMed:23396969, PubMed:28083649, PubMed:8027028, PubMed:8457197). Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of beta cells (PubMed:8027028). May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (PubMed:3399500). Also able to mediate the transport of dehydroascorbate and urate (PubMed:23396969, PubMed:40209957). {ECO:0000269|PubMed:16186102, ECO:0000269|PubMed:23396969, ECO:0000269|PubMed:28083649, ECO:0000269|PubMed:3399500, ECO:0000269|PubMed:40209957, ECO:0000269|PubMed:8027028, ECO:0000269|PubMed:8457197}.
uniprot
proteins
mass_dalton
57490
uniprot
proteins
mutagenesis
MUTAGEN 322; /note="I->V: Reduced fructose transport."; /evidence="ECO:0000269|PubMed:16186102, ECO:0000269|PubMed:28083649
uniprot
proteins
post_translational_modification
PTM: N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells. {ECO:0000250|UniProtKB:P14246}.
uniprot
proteins
protein_family
Glucose transporter subfamily
uniprot
proteins
protein_family
Major facilitator superfamily
uniprot
proteins
protein_family
Sugar transporter (TC 2.A.1.1) family
uniprot
proteins
pubmed
10987651
uniprot
proteins
pubmed
11044475
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
16186102
uniprot
proteins
pubmed
16641997
uniprot
proteins
pubmed
23396969
uniprot
proteins
pubmed
24275569
uniprot
proteins
pubmed
28083649
uniprot
proteins
pubmed
29548810
uniprot
proteins
pubmed
3399500
uniprot
proteins
pubmed
40209957
uniprot
proteins
pubmed
7593414
uniprot
proteins
pubmed
8027028
uniprot
proteins
pubmed
8063045
uniprot
proteins
pubmed
8457197
uniprot
proteins
sequence_length
524
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:28083649, ECO:0000269|PubMed:40209957}; Multi-pass membrane protein {ECO:0000255}.
uniprot
proteins
transmembrane_region
TRANSMEM 11..31; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 99..119; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 128..148; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 159..179; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 188..208; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 218..238; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 304..324; /note="Helical; Name=7"; /evidence="ECO:0000255"; TRANSMEM 339..359; /note="Helical; Name=8"; /evidence="ECO:0000255"; TRANSMEM 369..389; /note="Helical; Name=9"; /evidence="ECO:0000255"; TRANSMEM 401..421; /note="Helical; Name=10"; /evidence="ECO:0000255"; TRANSMEM 434..454; /note="Helical; Name=11"; /evidence="ECO:0000255"; TRANSMEM 462..482; /note="Helical; Name=12"; /evidence="ECO:0000255
uniprot
proteins