Glp1r
entrez
25051
canonical
uniprot
P32301
canonical
ensembl
ENSRNOG00000001152
resolver
ensp
ENSRNOP00000001527
resolver
enst
ENSRNOT00000001527
resolver
genesymbol
Glp1r
resolver
genesymbol_syn
Glpr
resolver
uniprot
F1LRH2
resolver
uniprot
Q64073
resolver
uniprot
Q6LD83
resolver
uniprot_entry
F1LRH2_RAT
resolver
uniprot_entry
GLP1R_RAT
resolver
uniprot_sec
Q64073
resolver
uniprot_sec
Q6LD83
resolver
amino_acid_sequence
MAVTPSLLRLALLLLGAVGRAGPRPQGATVSLSETVQKWREYRHQCQRFLTEAPLLATGLFCNRTFDDYACWPDGPPGSFVNVSCPWYLPWASSVLQGHVYRFCTAEGIWLHKDNSSLPWRDLSECEESKQGERNSPEEQLLSLYIIYTVGYALSFSALVIASAILVSFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLGCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVFSEQRIFKLYLSIGWGVPLLFVIPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLVFIRVICIVIAKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFVKLFTELSFTSFQGFMVAVLYCFVNNEVQMEFRKSWERWRLERLNIQRDSSMKPLKCPTSSVSSGATVGSSVYAATCQNSCS
uniprot
proteins
function
FUNCTION: G protein-coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:1326760, PubMed:7527026, PubMed:7813606). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:1326760, PubMed:7813606). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity). {ECO:0000250|UniProtKB:O35659, ECO:0000269|PubMed:1326760, ECO:0000269|PubMed:7527026, ECO:0000269|PubMed:7813606}.
uniprot
proteins
mass_dalton
52877
uniprot
proteins
post_translational_modification
PTM: N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER. {ECO:0000250|UniProtKB:P43220}.
uniprot
proteins
protein_family
G protein-coupled receptor 2 family
uniprot
proteins
pubmed
1326760
uniprot
proteins
pubmed
7527026
uniprot
proteins
pubmed
7813606
uniprot
proteins
sequence_length
463
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1326760, ECO:0000269|PubMed:7813606}; Multi-pass membrane protein {ECO:0000250|UniProtKB:P43220}.
uniprot
proteins
transmembrane_region
TRANSMEM 140..164; /note="Helical; Name=1"; /evidence="ECO:0000250|UniProtKB:P43220"; TRANSMEM 176..201; /note="Helical; Name=2"; /evidence="ECO:0000250|UniProtKB:P43220"; TRANSMEM 228..251; /note="Helical; Name=3"; /evidence="ECO:0000250|UniProtKB:P43220"; TRANSMEM 266..290; /note="Helical; Name=4"; /evidence="ECO:0000250|UniProtKB:P43220"; TRANSMEM 306..328; /note="Helical; Name=5"; /evidence="ECO:0000250|UniProtKB:P43220"; TRANSMEM 349..370; /note="Helical; Name=6"; /evidence="ECO:0000250|UniProtKB:P43220"; TRANSMEM 384..404; /note="Helical; Name=7"; /evidence="ECO:0000250|UniProtKB:P43220
uniprot
proteins