Polr3k
entrez
67005
canonical
uniprot
Q9CQZ7
canonical
ensembl
ENSMUSG00000038628
resolver
ensp
ENSMUSP00000044582
resolver
enst
ENSMUST00000039551
resolver
genesymbol
Polr3k
resolver
uniprot
Q3TSW1
resolver
uniprot
Q9D1U1
resolver
uniprot_entry
Q3TSW1_MOUSE
resolver
uniprot_entry
RPC10_MOUSE
resolver
uniprot_sec
Q9D1U1
resolver
amino_acid_sequence
MLLFCPGCGNGLIVEEGQRCHRFACNTCPYVHNITRKVTNRKYPKLKEVDDVLGGAAAWENVDSTAEPCPKCEHPRAYFMQLQTRSADEPMTTFYKCCNAQCGHRWRD
uniprot
proteins
function
FUNCTION: Core component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs using the four ribonucleoside triphosphates as substrates (By similarity). Can mediate Pol I proofreading of the nascent RNA transcript. Anchors into the Pol III active site to constantly monitor transcription fidelity, cleaves mis-incorporated 5'-ribonucleotides and restarts the transcription process. Once Pol III reaches the poly(dT) termination signal, can induce Pol III clamp opening and transcription termination (By similarity). Pol III plays an important role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF-kappa-B through the RIG-I pathway (By similarity). {ECO:0000250|UniProtKB:Q04307, ECO:0000250|UniProtKB:Q9Y2Y1}.
uniprot
proteins
mass_dalton
12330
uniprot
proteins
protein_family
Archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family
uniprot
proteins
pubmed
16141072
uniprot
proteins
sequence_length
108
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9Y2Y1}.
uniprot
proteins