LGR6
entrez
59352
canonical
uniprot
Q9HBX8
canonical
ensembl
ENSG00000133067
resolver
ensp
ENSP00000255432
resolver
ensp
ENSP00000356247
resolver
ensp
ENSP00000387869
resolver
ensp
ENSP00000574694
resolver
ensp
ENSP00000574698
resolver
ensp
ENSP00000574699
resolver
genesymbol
LGR6
resolver
hgnc
HGNC:19719
resolver
uniprot
Q5T509
resolver
uniprot
Q5T512
resolver
uniprot
Q6UY15
resolver
uniprot
Q86VU0
resolver
uniprot
Q96K69
resolver
uniprot
Q9BYD7
resolver
uniprot_entry
LGR6_HUMAN
resolver
uniprot_sec
Q5T509
resolver
uniprot_sec
Q5T512
resolver
uniprot_sec
Q6UY15
resolver
uniprot_sec
Q86VU0
resolver
uniprot_sec
Q96K69
resolver
uniprot_sec
Q9BYD7
resolver
amino_acid_sequence
MPSPPGLRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGNLALSQAFSKDSFPKLRILEVPYAYQCCPYGMCASFFKASGQWEAEDLHLDDEESSKRPLGLLARQAENHYDQDLDELQLEMEDSKPHPSVQCSPTPGPFKPCEYLFESWGIRLAVWAIVLLSVLCNGLVLLTVFAGGPVPLPPVKFVVGAIAGANTLTGISCGLLASVDALTFGQFSEYGARWETGLGCRATGFLAVLGSEASVLLLTLAAVQCSVSVSCVRAYGKSPSLGSVRAGVLGCLALAGLAAALPLASVGEYGASPLCLPYAPPEGQPAALGFTVALVMMNSFCFLVVAGAYIKLYCDLPRGDFEAVWDCAMVRHVAWLIFADGLLYCPVAFLSFASMLGLFPVTPEAVKSVLLVVLPLPACLNPLLYLLFNPHFRDDLRRLRPRAGDSGPLAYAAAGELEKSSCDSTQALVAFSDVDLILEASEAGRPPGLETYGFPSVTLISCQQPGAPRLEGSHCVEPEGNHFGNPQPSMDGELLLRAEGSTPAGGGLSGGGGFQPSGLAFASHV
uniprot
proteins
function
FUNCTION: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G protein-coupled receptors, does not activate heterotrimeric G proteins to transduce the signal. May act as a tumor suppressor. {ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:22615920}.
uniprot
proteins
mass_dalton
104298
uniprot
proteins
protein_family
G protein-coupled receptor 1 family
uniprot
proteins
pubmed
10935549
uniprot
proteins
pubmed
12044878
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16710414
uniprot
proteins
pubmed
16959974
uniprot
proteins
pubmed
21727895
uniprot
proteins
pubmed
22615920
uniprot
proteins
sequence_length
967
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22615920}; Multi-pass membrane protein {ECO:0000269|PubMed:22615920}.
uniprot
proteins
transmembrane_region
TRANSMEM 568..588; /note="Helical; Name=1"; /evidence="ECO:0000255"; TRANSMEM 599..619; /note="Helical; Name=2"; /evidence="ECO:0000255"; TRANSMEM 645..665; /note="Helical; Name=3"; /evidence="ECO:0000255"; TRANSMEM 688..708; /note="Helical; Name=4"; /evidence="ECO:0000255"; TRANSMEM 728..748; /note="Helical; Name=5"; /evidence="ECO:0000255"; TRANSMEM 775..795; /note="Helical; Name=6"; /evidence="ECO:0000255"; TRANSMEM 810..830; /note="Helical; Name=7"; /evidence="ECO:0000255
uniprot
proteins