MMP1
entrez
4312
canonical
uniprot
P03956
canonical
ensembl
ENSG00000196611
resolver
ensp
ENSP00000322788
resolver
enst
ENST00000315274
resolver
genesymbol
MMP1
resolver
genesymbol_syn
CLG
resolver
hgnc
HGNC:7155
resolver
uniprot
B4DN15
resolver
uniprot
P08156
resolver
uniprot
Q53G95
resolver
uniprot_entry
B4DN15_HUMAN
resolver
uniprot_entry
MMP1_HUMAN
resolver
uniprot_entry
Q53G95_HUMAN
resolver
uniprot_sec
P08156
resolver
activity_regulation
ACTIVITY REGULATION: Can be activated without removal of the activation peptide.
uniprot
proteins
amino_acid_sequence
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
uniprot
proteins
ec_number
3.4.24.7
uniprot
proteins
function
FUNCTION: Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X (PubMed:1645757, PubMed:2153297, PubMed:2557822). In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity (PubMed:16807369). {ECO:0000269|PubMed:1645757, ECO:0000269|PubMed:16807369, ECO:0000269|PubMed:2153297, ECO:0000269|PubMed:2557822}.
uniprot
proteins
mass_dalton
54007
uniprot
proteins
mutagenesis
MUTAGEN 360; /note="Y->F: Partial reduction of tyrosine phosphorylation in the presence of PKDCC/VLK."; /evidence="ECO:0000269|PubMed:25171405
uniprot
proteins
post_translational_modification
PTM: Undergoes autolytic cleavage to two major forms (22 kDa and 27 kDa). A minor form (25 kDa) is the glycosylated form of the 22 kDa form. The 27 kDa form has no activity while the 22/25 kDa form can act as activator for collagenase. {ECO:0000269|PubMed:10092871}.; PTM: Tyrosine phosphorylated in platelets by PKDCC/VLK. {ECO:0000269|PubMed:25171405}.
uniprot
proteins
protein_family
Peptidase M10A family
uniprot
proteins
pubmed
10092871
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15611040
uniprot
proteins
pubmed
1645757
uniprot
proteins
pubmed
16807369
uniprot
proteins
pubmed
2153297
uniprot
proteins
pubmed
2167156
uniprot
proteins
pubmed
25171405
uniprot
proteins
pubmed
2557822
uniprot
proteins
pubmed
3009463
uniprot
proteins
pubmed
3027129
uniprot
proteins
pubmed
3030290
uniprot
proteins
pubmed
3032950
uniprot
proteins
pubmed
3037355
uniprot
proteins
pubmed
7656013
uniprot
proteins
pubmed
8031754
uniprot
proteins
pubmed
8090713
uniprot
proteins
pubmed
8278810
uniprot
proteins
pubmed
9484219
uniprot
proteins
sequence_length
469
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix {ECO:0000305|PubMed:2167156}.
uniprot
proteins