Ptprr
entrez
19279
canonical
uniprot
Q62132
canonical
ensembl
ENSMUSG00000020151
resolver
ensp
ENSMUSP00000064392
resolver
ensp
ENSMUSP00000100907
resolver
ensp
ENSMUSP00000114455
resolver
ensp
ENSMUSP00000120965
resolver
ensp
ENSMUSP00000122259
resolver
ensp
ENSMUSP00000182832
resolver
genesymbol
Ptprr
resolver
genesymbol_syn
Ptp13
resolver
uniprot
Q5U1U5
resolver
uniprot
Q5U1U6
resolver
uniprot
Q64491
resolver
uniprot
Q64492
resolver
uniprot
Q8CEI8
resolver
uniprot
Q9QUH9
resolver
uniprot_entry
PTPRR_MOUSE
resolver
uniprot_entry
Q5U1U5_MOUSE
resolver
uniprot_entry
Q5U1U6_MOUSE
resolver
uniprot_entry
Q8CEI8_MOUSE
resolver
uniprot_sec
Q64491
resolver
uniprot_sec
Q64492
resolver
uniprot_sec
Q9QUH9
resolver
amino_acid_sequence
MRRAVGFPALCLLLNLHAAGCFSRNNDHFLAIRQKKSWKPVFIYDHSQDIKKSLDIAQEAYKHNYHSPSEVQISKHHQIINSAFPRPAYDPSLNLLAESDQDLEIENLPIPAANVIVVTLQMDITKLNITLLRIFRQGVAAALGLLPQQVHINRLIEKKNQVELFVSPGNRKPGETQALQAEEVLRSLNVDGLHQSLPQFGITDVAPEKNVLQGQHEADKIWSKEGFYAVVIFLSIFIIIVTCLMIIYRLKERLQLSLRQDKEKNQEIHLSPIARQQAQSEAKTTHSMVQPDQAPKVLNVVVDPQGQCTPEIRNSTSTSVCPSPFRMKPIGLQERRGSNVSLTLDMSSLGSVEPFVAVSTPREKVAMEYLQSASRVLTRSQLRDVVASSHLLQSEFMEIPMNFVDPKEIDIPRHGTKNRYKTILPNPLSRVCLRPKNITDSLSTYINANYIRGYSGKEKAFIATQGPMINTVNDFWQMVWQEDSPVIVMITKLKEKNEKCVLYWPEKRGIYGKVEVLVTGVTECDNYTIRNLVLKQGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASEGRGPVVVHCSAGIGRTGCFIATSIGCQQLKEEGVVDALSIVCQLRVDRGGMVQTSEQYEFVHHALCLFESRLSPETVE
uniprot
proteins
ec_number
3.1.3.48
uniprot
proteins
function
FUNCTION: Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus. Isoform gamma may have a role in patterning and cellular proliferation of skeletal elements in the precartilaginous/cartilaginous skeleton. {ECO:0000269|PubMed:10601328, ECO:0000269|PubMed:10949045}.
uniprot
proteins
mass_dalton
74036
uniprot
proteins
mutagenesis
MUTAGEN 338; /note="S->A: Loss of phosphorylation by PKA, constitutive MAPK binding."; /evidence="ECO:0000269|PubMed:10601328"; MUTAGEN 338; /note="S->E: Mimics phosphorylation by PKA, prevents MAPK binding."; /evidence="ECO:0000269|PubMed:10601328"; MUTAGEN 587; /note="C->S: Loss of phosphatase activity."; /evidence="ECO:0000269|PubMed:10601328"; MUTAGEN 593; /note="R->M: Loss of phosphatase activity."; /evidence="ECO:0000269|PubMed:10601328
uniprot
proteins
protein_family
Protein-tyrosine phosphatase family
uniprot
proteins
protein_family
Receptor class 7 subfamily
uniprot
proteins
pubmed
10601328
uniprot
proteins
pubmed
10705342
uniprot
proteins
pubmed
10949045
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
7832766
uniprot
proteins
pubmed
7836467
uniprot
proteins
sequence_length
656
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform Alpha]: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: [Isoform Beta]: Cytoplasm. Note=Locates to the areas within the cytoplasm.; SUBCELLULAR LOCATION: [Isoform Gamma]: Cytoplasm. Note=Locates to the areas within the cytoplasm.
uniprot
proteins
transmembrane_region
TRANSMEM 227..247; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins