Npr2
entrez
116564
canonical
uniprot
P16067
canonical
ensembl
ENSRNOG00000015991
resolver
ensp
ENSRNOP00000021802
resolver
ensp
ENSRNOP00000086809
resolver
enst
ENSRNOT00000021802
resolver
genesymbol
Npr2
resolver
uniprot
A0A8L2UJL6
resolver
uniprot_entry
A0A8L2UJL6_RAT
resolver
uniprot_entry
ANPRB_RAT
resolver
amino_acid_sequence
MALPSLLLVVAALAGGVRPPGARNLTLAVVLPEHNLSYAWAWPRVGPAVALAVEALGRALPVDLRFVSSELDGACSEYLAPLRAVDLKLYHDPDLLLGPGCVYPAASVARFASHWHLPLLTAGAVASGFAAKNEHYRTLVRTGPSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPHYFTIEGVFEALQGSNLSVQHQVYTREPGGPEQATHFIRANGRIVYICGPLEMLHEILLQAQRENLTNGDYVFFYLDVFGESLRAGPTRATGRPWQDNRTQEQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIVEKMQGRRYHGVTGLVVMDKNNDRETDFVLWAMGDLESGDFQPAAHYSGAEKQIWWTGRPIPWVKGAPPLDNPPCAFDLDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRKLMLEKELASMLWRIRWEELQFGNSDRYHKGAGSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNKKRIELTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLINDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHALYAKKLWTAPELLSGNPLPTTGMQKADVYSFAIILQEIALRSGPFYLEGLDLSPKEIVQKVRNGQRPYFRPSIDRTQLNEELVLLMERCWAQDPTERPDFGQIKGFIRRFNKEGGTSILDNLLLRMEQYANNLEKLVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIRHRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDELGCFQLELRGDVEMKGKGKMRTYWLLGERKGPPGLL
uniprot
proteins
ec_number
4.6.1.2
uniprot
proteins
function
FUNCTION: Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth. {ECO:0000250|UniProtKB:P20594}.
uniprot
proteins
mass_dalton
117127
uniprot
proteins
mutagenesis
MUTAGEN 513; /note="S->A: Reduced phosphorylation, 30% loss of CNP-dependent activity."; /evidence="ECO:0000269|PubMed:9624142"; MUTAGEN 516; /note="T->A: Reduced phosphorylation, 30% loss of CNP-dependent activity."; /evidence="ECO:0000269|PubMed:9624142"; MUTAGEN 518; /note="S->A: Reduced phosphorylation, 30% loss of CNP-dependent activity."; /evidence="ECO:0000269|PubMed:9624142"; MUTAGEN 521; /note="G->A: Reduced phosphorylation, 50% loss of CNP-dependent activity."; /evidence="ECO:0000269|PubMed:9624142"; MUTAGEN 522; /note="S->A: Reduced phosphorylation, 30% loss of CNP-dependent activity."; /evidence="ECO:0000269|PubMed:9624142"; MUTAGEN 523; /note="S->A: Markedly reduced phosphorylation, 70% loss of CNP-dependent activity."; /evidence="ECO:0000269|PubMed:9624142"; MUTAGEN 526; /note="S->A: Markedly reduced phosphorylation, 80% loss of CNP-dependent activity."; /evidence="ECO:0000269|PubMed:9624142"; MUTAGEN 529; /note="T->A: No effect on phosphorylation, 30% loss of CNP-dependent activity."; /evidence="ECO:0000269|PubMed:9624142
uniprot
proteins
post_translational_modification
PTM: Phosphorylated. Phosphorylation of the protein kinase-like domain is required for full activation by CNP. {ECO:0000269|PubMed:20977274, ECO:0000269|PubMed:9624142}.; PTM: Glycosylated. {ECO:0000250|UniProtKB:P20594}.
uniprot
proteins
protein_family
Adenylyl cyclase class-4/guanylyl cyclase family
uniprot
proteins
pubmed
20977274
uniprot
proteins
pubmed
2570641
uniprot
proteins
pubmed
9624142
uniprot
proteins
sequence_length
1047
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P20594}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P20594}.
uniprot
proteins
transmembrane_region
TRANSMEM 459..478; /note="Helical"; /evidence="ECO:0000255
uniprot
proteins