ADCYAP1R1
entrez
117
canonical
uniprot
P41586
canonical
ensembl
ENSG00000078549
resolver
ensp
ENSP00000306620
resolver
ensp
ENSP00000379514
resolver
ensp
ENSP00000387335
resolver
ensp
ENSP00000516124
resolver
ensp
ENSP00000523973
resolver
ensp
ENSP00000523974
resolver
ensp
ENSP00000523975
resolver
ensp
ENSP00000523976
resolver
enst
ENST00000705423
resolver
genesymbol
ADCYAP1R1
resolver
hgnc
HGNC:242
resolver
uniprot
A0A994J7E9
resolver
uniprot
A8K1Y1
resolver
uniprot
B7ZLA7
resolver
uniprot
B8ZZK3
resolver
uniprot
Q17S10
resolver
uniprot_entry
A0A994J7E9_HUMAN
resolver
uniprot_entry
PACR_HUMAN
resolver
uniprot_sec
A8K1Y1
resolver
uniprot_sec
B7ZLA7
resolver
uniprot_sec
B8ZZK3
resolver
uniprot_sec
Q17S10
resolver
activity_regulation
ACTIVITY REGULATION: Several synthetic peptides derived from maxadilan, a vasodilator peptide from Lutzomyia longipalpis saliva, act as antagonists for ADCYAP1R1. {ECO:0000269|PubMed:33715378}.
uniprot
proteins
amino_acid_sequence
MAGVVHVSLAALLLLPMAPAMHSDCIFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWDNITCWKPAHVGEMVLVSCPELFRIFNPDQVWETETIGESDFGDSNSLDLSDMGVVSRNCTEDGWSEPFPHYFDACGFDEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRKLHCTRNFIHMNLFVSFMLRAISVFIKDWILYAEQDSNHCFISTVECKAVMVFFHYCVVSNYFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMNDSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIYLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELGLGSFQGFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFKHRHPSLASSGVNGGTQLSILSKSSSQIRMSGLPADNLAT
uniprot
proteins
function
FUNCTION: G protein-coupled receptor activated by the neuropeptide pituitary adenylate cyclase-activating polypeptide (ADCYAP1/PACAP) (PubMed:32004469, PubMed:32047270, PubMed:33715378, PubMed:35477937, PubMed:36385145). Binds both PACAP27 and PACAP38 bioactive peptides (PubMed:32004469, PubMed:32047270, PubMed:35477937, PubMed:36385145). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors. Activates cAMP-dependent pathway (PubMed:32004469, PubMed:32047270, PubMed:33715378, PubMed:35477937, PubMed:36385145). May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract (PubMed:32047270, PubMed:33715378). {ECO:0000269|PubMed:32004469, ECO:0000269|PubMed:32047270, ECO:0000269|PubMed:33715378, ECO:0000269|PubMed:35477937, ECO:0000269|PubMed:36385145}.
uniprot
proteins
mass_dalton
53314
uniprot
proteins
mutagenesis
MUTAGEN 114; /note="V->A: Reduced affinity for ADCYAP1."; /evidence="ECO:0000269|PubMed:17470806"; MUTAGEN 125; /note="E->R: Reduced affinity for ADCYAP1."; /evidence="ECO:0000269|PubMed:17470806, ECO:0000269|PubMed:21625560"; MUTAGEN 128; /note="P->A: Reduced affinity for ADCYAP1."; /evidence="ECO:0000269|PubMed:17470806"; MUTAGEN 130; /note="Y->A: Decreases maxadilan-induced receptor activity in the functional cAMP assay. Does not affect PACAP-38-induced receptor activity."; /evidence="ECO:0000269|PubMed:32047270"; MUTAGEN 131; /note="F->A: Decreases maxadilan-induced receptor activity in the functional cAMP assay. Does not affect PACAP-38-induced receptor activity."; /evidence="ECO:0000269|PubMed:32047270"; MUTAGEN 138; /note="E->R: Reduced affinity for ADCYAP1."; /evidence="ECO:0000269|PubMed:17470806"; MUTAGEN 139; /note="Y->A: Strongly reduced affinity for ADCYAP1."; /evidence="ECO:0000269|PubMed:17470806"; MUTAGEN 150; /note="Y->A: Decreased ADCYAP1/PACAP27 potency for ADCYAP1R1."; /evidence="ECO:0000269|PubMed:35477937"; MUTAGEN 157; /note="Y->A: Decreases maxadilan-induced receptor activity in the functional cAMP assay. Does not affect PACAP-38-induced receptor activity."; /evidence="ECO:0000269|PubMed:32047270"; MUTAGEN 161; /note="Y->A: Decreases PACAP-38-induced receptor activity in the functional cAMP assay. Decreases maxadilan-induced receptor activity."; /evidence="ECO:0000269|PubMed:32047270"; MUTAGEN 199; /note="R->A: Decreases PACAP-38-induced receptor activity in the functional cAMP assay. Slightly decreases maxadilan-induced receptor activity."; /evidence="ECO:0000269|PubMed:32047270"; MUTAGEN 206; /note="K->A: Decreases PACAP-38-induced receptor activity in the functional cAMP assay. Decreases maxadilan-induced receptor activity."; /evidence="ECO:0000269|PubMed:32047270"; MUTAGEN 207; /note="D->A: Decreases PACAP-38-induced receptor activity in the functional cAMP assay. Decreases maxadilan-induced receptor activity."; /evidence="ECO:0000269|PubMed:32047270"; MUTAGEN 299; /note="M->A: Decreases maxadilan-induced receptor activity in the functional cAMP assay. Does not affect PACAP-38-induced receptor activity."; /evidence="ECO:0000269|PubMed:32047270"; MUTAGEN 301; /note="D->A: Decreases maxadilan-induced receptor activity in the functional cAMP assay. Does not affect PACAP-38-induced receptor activity."; /evidence="ECO:0000269|PubMed:32047270"; MUTAGEN 306; /note="W->A: Decreases PACAP-38-induced receptor activity in the functional cAMP assay. Decreases maxadilan-induced receptor activity."; /evidence="ECO:0000269|PubMed:32047270"; MUTAGEN 381; /note="R->A: Decreases PACAP-38-induced receptor activity in the functional cAMP assay. Decreases maxadilan-induced receptor activity."; /evidence="ECO:0000269|PubMed:32047270"; MUTAGEN 382; /note="L->A: Decreases maxadilan-induced receptor activity in the functional cAMP assay. Does not affect PACAP-38-induced receptor activity."; /evidence="ECO:0000269|PubMed:32047270"; MUTAGEN 385; /note="E->A: Decreases maxadilan-induced receptor activity in the functional cAMP assay. Does not affect PACAP-38-induced receptor activity."; /evidence="ECO:0000269|PubMed:32047270
uniprot
proteins
protein_family
G protein-coupled receptor 2 family
uniprot
proteins
pubmed
10583729
uniprot
proteins
pubmed
12853948
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
17470806
uniprot
proteins
pubmed
21625560
uniprot
proteins
pubmed
32004469
uniprot
proteins
pubmed
32047270
uniprot
proteins
pubmed
33715378
uniprot
proteins
pubmed
35477937
uniprot
proteins
pubmed
36385145
uniprot
proteins
pubmed
7851900
uniprot
proteins
pubmed
7902709
uniprot
proteins
sequence_length
468
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein {ECO:0000269|PubMed:36385145}.
uniprot
proteins
transmembrane_region
TRANSMEM 153..177; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:32004469, ECO:0000269|PubMed:36385145, ECO:0007744|PDB:6P9Y, ECO:0007744|PDB:8E3X"; TRANSMEM 188..208; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:32004469, ECO:0000269|PubMed:36385145, ECO:0007744|PDB:6P9Y, ECO:0007744|PDB:8E3X"; TRANSMEM 224..249; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:32004469, ECO:0000269|PubMed:36385145, ECO:0007744|PDB:6P9Y, ECO:0007744|PDB:8E3X"; TRANSMEM 268..290; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:32004469, ECO:0000269|PubMed:36385145, ECO:0007744|PDB:6P9Y, ECO:0007744|PDB:8E3X"; TRANSMEM 303..329; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:32004469, ECO:0000269|PubMed:36385145, ECO:0007744|PDB:6P9Y, ECO:0007744|PDB:8E3X"; TRANSMEM 348..374; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:32004469, ECO:0000269|PubMed:36385145, ECO:0007744|PDB:6P9Y, ECO:0007744|PDB:8E3X"; TRANSMEM 380..403; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:32004469, ECO:0000269|PubMed:32047270, ECO:0007744|PDB:6M1I, ECO:0007744|PDB:6P9Y
uniprot
proteins