Slc6a6
entrez
21366
canonical
uniprot
O35316
canonical
ensembl
ENSMUSG00000030096
resolver
ensp
ENSMUSP00000032185
resolver
ensp
ENSMUSP00000277524
resolver
ensp
ENSMUSP00000277531
resolver
ensp
ENSMUSP00000277548
resolver
ensp
ENSMUSP00000277549
resolver
ensp
ENSMUSP00000336046
resolver
ensp
ENSMUSP00000355595
resolver
enst
ENSMUST00000032185
resolver
genesymbol
Slc6a6
resolver
genesymbol_syn
Taut
resolver
uniprot
P31642
resolver
uniprot
Q3UPI8
resolver
uniprot
Q8BRX2
resolver
uniprot
Q91WI2
resolver
uniprot_entry
Q3UPI8_MOUSE
resolver
uniprot_entry
Q8BRX2_MOUSE
resolver
uniprot_entry
SC6A6_MOUSE
resolver
uniprot_sec
P31642
resolver
uniprot_sec
Q91WI2
resolver
activity_regulation
ACTIVITY REGULATION: Taurine transport activity is stimulated by thyrotropin. Taurine transport activity is inhibited by GABA, hypotaurine and beta-alanine (By similarity). GABA transport activity is inhibited by taurine and beta-alanine (PubMed:1465453, PubMed:9375654). Taurine transport activity is inhibited by L-alanine, guanidinoethane sulfonate (GES), piperidine-4-sulfonic acid, imidazole-4-acetatic acid, 5-aminovaleric acid, nipecotic acid, homotaurine and phorbol 12-myristate 13-acetate (PubMed:40601627). Taurine transport activity is stimulated by hypertonic stress (By similarity). {ECO:0000250|UniProtKB:P31641, ECO:0000250|UniProtKB:Q9MZ34, ECO:0000269|PubMed:1465453, ECO:0000269|PubMed:40601627, ECO:0000269|PubMed:9375654}.
uniprot
proteins
amino_acid_sequence
MATKEKLQCLKDFHKDILKPSPGKSPGTRPEDEADGKPPQREKWSSKIDFVLSVAGGFVGLGNVWRFPYLCYKNGGGAFLIPYFIFLFGSGLPVFFLEVIIGQYTSEGGITCWEKICPLFSGIGYASIVIVSLLNVYYIVILAWATYYLFHSFQKDLPWAHCNHSWNTPQCMEDTLRRNESHWVSLSTANFTSPVIEFWERNVLSLSSGIDNPGSLKWDLALCLLLVWLVCFFCIWKGVRSTGKVVYFTATFPFAMLLVLLVRGLTLPGAGEGIKFYLYPDISRLGDPQVWIDAGTQIFFSYAICLGAMTSLGSYNKYKYNSYRDCMLLGCLNSGTSFVSGFAIFSILGFMAQEQGVDIADVAESGPGLAFIAYPKAVTMMPLPTFWSILFFIMLLLLGLDSQFVEVEGQITSLVDLYPSFLRKGYRREIFIAILCSISYLLGLTMVTEGGMYVFQLFDYYAASGVCLLWVAFFECFVIAWIYGGDNLYDGIEDMIGYRPGPWMKYSWAVITPALCVGCFVFSLVKYVPLTYNKVYRYPDWAIGLGWGLALSSMLCIPLVIVILLCRTEGPLRVRIKYLITPREPNRWAVEREGATPFHSRVTLMNGALMKPSHVIVETMM
uniprot
proteins
function
FUNCTION: Mediates sodium- and chloride-dependent transport of taurine, a key amino acid (PubMed:1465453, PubMed:30270321, PubMed:37289866, PubMed:40601627, PubMed:9375654). Taurine acts as an anti-aging agent by reducing cellular senescence and combating oxidative stress: levels decline with age and supplementation has been shown to extend lifespan (PubMed:37289866). In addition to mediate extracellular taurine uptake, also able to mediate transport of taurine into mitochondria, sustaining mitochondrial translation (By similarity). Can also mediate transport of beta-alanine, hypotaurine and gamma-aminobutyric acid (GABA) (PubMed:1465453, PubMed:30270321, PubMed:9375654). {ECO:0000250|UniProtKB:P31641, ECO:0000269|PubMed:1465453, ECO:0000269|PubMed:30270321, ECO:0000269|PubMed:37289866, ECO:0000269|PubMed:40601627, ECO:0000269|PubMed:9375654}.
uniprot
proteins
mass_dalton
69856
uniprot
proteins
mutagenesis
MUTAGEN 58; /note="F->A: Decreased taurine transport."; /evidence="ECO:0000269|PubMed:40601627"; MUTAGEN 63; /note="N->A: Decreased taurine transport."; /evidence="ECO:0000269|PubMed:40601627"; MUTAGEN 83; /note="Y->A: Decreased taurine transport."; /evidence="ECO:0000269|PubMed:40601627"; MUTAGEN 135; /note="N->A: Decreased taurine transport."; /evidence="ECO:0000269|PubMed:40601627"; MUTAGEN 297; /note="Q->A: Decreased taurine transport."; /evidence="ECO:0000269|PubMed:40601627"; MUTAGEN 301; /note="S->A: Decreased taurine transport."; /evidence="ECO:0000269|PubMed:40601627"; MUTAGEN 333; /note="N->A: Decreased taurine transport."; /evidence="ECO:0000269|PubMed:40601627"; MUTAGEN 337; /note="S->A: Decreased taurine transport."; /evidence="ECO:0000269|PubMed:40601627"; MUTAGEN 337; /note="S->E: Strong taurine-binding independent of chloride ion."; /evidence="ECO:0000269|PubMed:40601627"; MUTAGEN 403; /note="Q->A: Decreased taurine transport."; /evidence="ECO:0000269|PubMed:40601627
uniprot
proteins
post_translational_modification
PTM: Phosphorylation at Ser-21 and Ser-25 by PKA promotes localization at the plasma while inhibiting mitochondrial localization (By similarity). Taurine transport activity is down-regulated upon Ser-322 phosphorylation (By similarity). {ECO:0000250|UniProtKB:P31641, ECO:0000250|UniProtKB:Q00589}.
uniprot
proteins
protein_family
SLC6A6 subfamily
uniprot
proteins
protein_family
Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
uniprot
proteins
pubmed
11772953
uniprot
proteins
pubmed
1465453
uniprot
proteins
pubmed
14734644
uniprot
proteins
pubmed
15149840
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16421246
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22896705
uniprot
proteins
pubmed
30270321
uniprot
proteins
pubmed
30862735
uniprot
proteins
pubmed
37289866
uniprot
proteins
pubmed
40601627
uniprot
proteins
pubmed
9375654
uniprot
proteins
sequence_length
621
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P31641}; Multi-pass membrane protein {ECO:0000269|PubMed:40601627}. Mitochondrion inner membrane {ECO:0000250|UniProtKB:P31641}; Multi-pass membrane protein {ECO:0000269|PubMed:40601627}. Note=Phosphorylation at Ser-21 and Ser-25 by PKA promotes localization at the plasma while inhibiting mitochondrial localization. {ECO:0000250|UniProtKB:P31641}.
uniprot
proteins
transmembrane_region
TRANSMEM 50..70; /note="Helical; Name=1"; /evidence="ECO:0000269|PubMed:40601627, ECO:0007744|PDB:9KMI, ECO:0007744|PDB:9KYO"; TRANSMEM 79..102; /note="Helical; Name=2"; /evidence="ECO:0000269|PubMed:40601627, ECO:0007744|PDB:9KMI, ECO:0007744|PDB:9KYO"; TRANSMEM 128..150; /note="Helical; Name=3"; /evidence="ECO:0000269|PubMed:40601627, ECO:0007744|PDB:9KMI, ECO:0007744|PDB:9KYO"; TRANSMEM 216..236; /note="Helical; Name=4"; /evidence="ECO:0000269|PubMed:40601627, ECO:0007744|PDB:9KMI, ECO:0007744|PDB:9KYO"; TRANSMEM 245..265; /note="Helical; Name=5"; /evidence="ECO:0000269|PubMed:40601627, ECO:0007744|PDB:9KMI, ECO:0007744|PDB:9KYO"; TRANSMEM 290..310; /note="Helical; Name=6"; /evidence="ECO:0000269|PubMed:40601627, ECO:0007744|PDB:9KMI, ECO:0007744|PDB:9KYO"; TRANSMEM 337..352; /note="Helical; Name=7"; /evidence="ECO:0000269|PubMed:40601627, ECO:0007744|PDB:9KMI, ECO:0007744|PDB:9KYO"; TRANSMEM 380..400; /note="Helical; Name=8"; /evidence="ECO:0000269|PubMed:40601627, ECO:0007744|PDB:9KMI, ECO:0007744|PDB:9KYO"; TRANSMEM 430..458; /note="Helical; Name=9"; /evidence="ECO:0000269|PubMed:40601627, ECO:0007744|PDB:9KMI, ECO:0007744|PDB:9KYO"; TRANSMEM 465..482; /note="Helical; Name=10"; /evidence="ECO:0000269|PubMed:40601627, ECO:0007744|PDB:9KMI, ECO:0007744|PDB:9KYO"; TRANSMEM 506..525; /note="Helical; Name=11"; /evidence="ECO:0000269|PubMed:40601627, ECO:0007744|PDB:9KMI, ECO:0007744|PDB:9KYO"; TRANSMEM 545..563; /note="Helical; Name=12"; /evidence="ECO:0000269|PubMed:40601627, ECO:0007744|PDB:9KMI, ECO:0007744|PDB:9KYO
uniprot
proteins