CFDP1
entrez
10428
canonical
uniprot
Q9UEE9
canonical
ensembl
ENSG00000153774
resolver
ensp
ENSP00000283882
resolver
ensp
ENSP00000648236
resolver
genesymbol
CFDP1
resolver
genesymbol_syn
BCNT
resolver
genesymbol_syn
CENP-29
resolver
hgnc
HGNC:1873
resolver
uniprot
A0A0H5APX3
resolver
uniprot
A0A0H5AUJ9
resolver
uniprot
O00393
resolver
uniprot
O00404
resolver
uniprot
Q9UEF0
resolver
uniprot
Q9UEF1
resolver
uniprot
Q9UEF8
resolver
uniprot_entry
A0A0H5APX3_HUMAN
resolver
uniprot_entry
A0A0H5AUJ9_HUMAN
resolver
uniprot_entry
CFDP1_HUMAN
resolver
uniprot_sec
O00393
resolver
uniprot_sec
O00404
resolver
uniprot_sec
Q9UEF0
resolver
uniprot_sec
Q9UEF1
resolver
uniprot_sec
Q9UEF8
resolver
amino_acid_sequence
MEEFDSEDFSTSEEDEDYVPSGGEYSEDDVNELVKEDEVDGEEQTQKTQGKKRKAQSIPARKRRQGGLSLEEEEEEDANSESEGSSSEEEDDAAEQEKGIGSEDARKKKEDELWASFLNDVGPKSKVPPSTQVKKGEETEETSSSKLLVKAEELEKPKETEKVKITKVFDFAGEEVRVTKEVDATSKEAKSFFKQNEKEKPQANVPSALPSLPAGSGLKRSSGMSSLLGKIGAKKQKMSTLEKSKLDWESFKEEEGIGEELAIHNRGKEGYIERKAFLDRVDHRQFEIERDLRLSKMKP
uniprot
proteins
function
FUNCTION: Required for the structural stability of pericentromeric heterochromatin (PubMed:28367969). Regulates heterochromatin state by stabilizing CBX5/HP1alpha and H3K9me3 at major satellites and CENPA at minor satellites and is required for incorporation of histone H2AZ1/H2AZ into chromatin (By similarity). Maintenance of chromatin structure promotes binding of guanine-nucleotide releasing factor RCC1 to minor and major satellite repeats (By similarity). Chromatin-bound RCC1 maintains high levels of GTP-bound RAN near the centromeric heterochromatin, facilitating RAN-mediated microtubule nucleation during mitosis (By similarity). Plays a role in craniofacial development (By similarity). Required to maintain normal cell function in embryonic development (By similarity). {ECO:0000250|UniProtKB:O88271, ECO:0000269|PubMed:28367969}.
uniprot
proteins
mass_dalton
33593
uniprot
proteins
mutagenesis
MUTAGEN 250; /note="S->A,E: Altered electrophoretic mobility."; /evidence="ECO:0000269|PubMed:26182435
uniprot
proteins
post_translational_modification
PTM: Phosphorylated by CK2 (casein kinase II) in vitro. {ECO:0000269|PubMed:10350657}.
uniprot
proteins
protein_family
SWC5/CFDP1/CFDP2 family
uniprot
proteins
pubmed
10350657
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
20068231
uniprot
proteins
pubmed
20813266
uniprot
proteins
pubmed
21269460
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
24129315
uniprot
proteins
pubmed
26182435
uniprot
proteins
pubmed
28112733
uniprot
proteins
pubmed
28367969
uniprot
proteins
pubmed
9006920
uniprot
proteins
pubmed
9602175
uniprot
proteins
sequence_length
299
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore {ECO:0000269|PubMed:20813266}. Nucleus {ECO:0000269|PubMed:28367969}. Chromosome {ECO:0000269|PubMed:28367969}. Note=Colocalizes with heterochromatin at major and minor satellites. {ECO:0000250|UniProtKB:O88271}.
uniprot
proteins