Eefsec
entrez
65967
canonical
uniprot
Q9JHW4
canonical
ensembl
ENSMUSG00000033216
resolver
ensp
ENSMUSP00000131207
resolver
ensp
ENSMUSP00000144839
resolver
ensp
ENSMUSP00000145480
resolver
ensp
ENSMUSP00000253224
resolver
ensp
ENSMUSP00000253235
resolver
ensp
ENSMUSP00000346671
resolver
ensp
ENSMUSP00000352925
resolver
enst
ENSMUST00000165242
resolver
enst
ENSMUST00000205179
resolver
genesymbol
Eefsec
resolver
genesymbol_syn
Selb
resolver
uniprot
A0A0N4SUV6
resolver
uniprot
Q3UGH6
resolver
uniprot
Q6GTZ5
resolver
uniprot_entry
A0A0N4SUV6_MOUSE
resolver
uniprot_entry
Q3UGH6_MOUSE
resolver
uniprot_entry
SELB_MOUSE
resolver
uniprot_sec
Q6GTZ5
resolver
amino_acid_sequence
MAGRRVNVNVGVLGHIDSGKTALARALSTTASTAAFDKQPQSRERGITLDLGFSCFVVPLPGAEPGSSDTLLQVTLVDCPGHASLIRTIIGGAQIIDLMMLVIDVTKGMQTQSAECLVIGQIACQKLVVVLNKIDLLAEGKRQAAIDKMTKKMQKTLENTKFRGAPIIPVAAKPGGPEAPETEAPQGISELIELLKSQISIPTRDPSGPFLMSVDHCFSIKGQGTVMTGTILSGTISLGDSVEIPALKVVKKVKSMQMFHTPVTSAMQGDRLGICVTQFDPKLLERGLVCAPESLHTVHAALISVEKIPYFRGPLQTKAKFHITVGHETVMGRTLFFSPAPDSFDLEPVLDSFDLSREYLFQEQYLCKDSMPTATEGDDEADPKAGHAPGGHCPRQQWALVEFEKPVTCPRLCLVIGSRLDADIHTNTCRLAFHGVLLQGLEDKNYIESFLPALRVYKLKHKHGLVERVMDDYSVIGRSLFKKETNIQLFVGLKVQLSTGEQGIIDSAFGQSGKFKIHIPGGLSPESKKILTPTLKKRSRAGRGETTKPEEGTERPEPIQPVTLNLSFKRYVFDTQKRMVQTP
uniprot
proteins
ec_number
3.6.5.-
uniprot
proteins
function
FUNCTION: Translation factor required for the incorporation of the rare amino acid selenocysteine encoded by UGA codons (PubMed:10970870, PubMed:11265756, PubMed:22992746). Replaces the eRF1-eRF3-GTP ternary complex for the insertion of selenocysteine directed by the UGA codon (PubMed:10970870, PubMed:11265756, PubMed:22992746). Insertion of selenocysteine at UGA codons is mediated by SECISBP2 and EEFSEC: SECISBP2 (1) specifically binds the SECIS sequence once the 80S ribosome encounters an in-frame UGA codon and (2) contacts the RPS27A/eS31 of the 40S ribosome before ribosome stalling (By similarity). (3) GTP-bound EEFSEC then delivers selenocysteinyl-tRNA(Sec) to the 80S ribosome and adopts a preaccommodated state conformation (By similarity). (4) After GTP hydrolysis, EEFSEC dissociates from the assembly, selenocysteinyl-tRNA(Sec) accommodates, and peptide bond synthesis and selenoprotein elongation occur (By similarity). {ECO:0000250|UniProtKB:P57772, ECO:0000269|PubMed:10970870, ECO:0000269|PubMed:11265756, ECO:0000269|PubMed:22992746}.
uniprot
proteins
mass_dalton
63539
uniprot
proteins
mutagenesis
MUTAGEN 466..470; /note="VERVM->AAAAA: Slightly decreased incorporation of selenocysteine."; /evidence="ECO:0000269|PubMed:22992746"; MUTAGEN 480..484; /note="LFKKE->AAAAA: Decreased incorporation of selenocysteine."; /evidence="ECO:0000269|PubMed:22992746"; MUTAGEN 509..513; /note="FGQSG->AAAAA: Decreased incorporation of selenocysteine."; /evidence="ECO:0000269|PubMed:22992746"; MUTAGEN 536..540; /note="KKRSR->AAAAA: Decreased incorporation of selenocysteine."; /evidence="ECO:0000269|PubMed:22992746"; MUTAGEN 569..573; /note="KRYVF->AAAAA: Decreased incorporation of selenocysteine."; /evidence="ECO:0000269|PubMed:22992746
uniprot
proteins
protein_family
Classic translation factor GTPase family
uniprot
proteins
protein_family
SelB subfamily
uniprot
proteins
protein_family
TRAFAC class translation factor GTPase superfamily
uniprot
proteins
pubmed
10970870
uniprot
proteins
pubmed
11265756
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
22992746
uniprot
proteins
pubmed
24129315
uniprot
proteins
sequence_length
583
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}. Nucleus {ECO:0000305}.
uniprot
proteins