Pde2a
entrez
81743
canonical
uniprot
Q01062
canonical
ensembl
ENSRNOG00000019560
resolver
ensp
ENSRNOP00000026586
resolver
ensp
ENSRNOP00000105612
resolver
ensp
ENSRNOP00000110326
resolver
enst
ENSRNOT00000130973
resolver
genesymbol
Pde2a
resolver
uniprot
A0ABK0LIT3
resolver
uniprot_entry
A0ABK0LIT3_RAT
resolver
uniprot_entry
PDE2A_RAT
resolver
activity_regulation
ACTIVITY REGULATION: The 3',5'-cyclic-AMP phosphodiesterase activity is stimulated by 3',5'-cyclic GMP (By similarity). Specifically inhibited by Bay 60-7550. When repressed, protected from ionomycin- but not staurosporin-induced cell death. {ECO:0000250|UniProtKB:O00408, ECO:0000269|PubMed:28463107}.
uniprot
proteins
amino_acid_sequence
MVLVLHHILIAVVQFLRRGQQVFLKPDEPPPQPCADSLQDALLSLGAVIDIAGLRQAAKDALSAVLPKVETVYTYLVDGESRLVCEDPPHELPQEGKIREAVISRKRLSCDGLGPSDLLGKPLARLVAPLAPDTQVLVIPLLDKETGTVAAVILVHCGQLSDSEEQSLQVVEKHALVALQRVQALQQRRPEAVQNTSADPSEDQKDEKGYTAHDRKILQLCGELYDLDATSLQLKVLRYLQQETQATHCCLLLVSEDNLQLSCKVIGEKVLGEEVSFPLTMGRLGQVVEDKQCIQLKDLTSDDVQQLQNMLGCELRAMLCVPVISRATDQVVALACAFNKLGGDFFTDEDERAIQHCFHYTGTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITEARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPDAYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAFSIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNFANFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNLELSNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYSSEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSHKFTIRGLPSNNSLDFLDEEYEVPDLDVTRAPVNGCCSLEG
uniprot
proteins
ec_number
3.1.4.17
uniprot
proteins
function
FUNCTION: cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP (By similarity). Plays a role in cell growth and migration (By similarity). {ECO:0000250|UniProtKB:O00408}.; FUNCTION: [Isoform PDE2A2]: Regulates mitochondrial cAMP levels and respiration (By similarity). Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of Dnm1l (PubMed:28463107). {ECO:0000250|UniProtKB:Q922S4, ECO:0000269|PubMed:28463107}.
uniprot
proteins
mass_dalton
104664
uniprot
proteins
protein_family
Cyclic nucleotide phosphodiesterase family
uniprot
proteins
protein_family
PDE2 subfamily
uniprot
proteins
pubmed
1326532
uniprot
proteins
pubmed
21724846
uniprot
proteins
pubmed
22673903
uniprot
proteins
pubmed
28463107
uniprot
proteins
pubmed
7811274
uniprot
proteins
sequence_length
928
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: [Isoform PDE2A3]: Cell membrane {ECO:0000250|UniProtKB:O00408}; Peripheral membrane protein {ECO:0000305}.; SUBCELLULAR LOCATION: [Isoform PDE2A1]: Cytoplasm {ECO:0000250|UniProtKB:O00408}.; SUBCELLULAR LOCATION: [Isoform PDE2A2]: Mitochondrion matrix {ECO:0000269|PubMed:21724846}. Mitochondrion inner membrane {ECO:0000269|PubMed:28463107}. Mitochondrion outer membrane {ECO:0000269|PubMed:28463107}.
uniprot
proteins