Gna12
entrez
14673
canonical
uniprot
P27600
canonical
ensembl
ENSMUSG00000000149
resolver
ensp
ENSMUSP00000000153
resolver
enst
ENSMUST00000000153
resolver
genesymbol
Gna12
resolver
genesymbol_syn
Gna-12
resolver
uniprot_entry
GNA12_MOUSE
resolver
amino_acid_sequence
MSGVVRTLSRCLLPAEAGARERRAGAARDAEREARRRSRDIDALLARERRAVRRLVKILLLGAGESGKSTFLKQMRIIHGREFDQKALLEFRDTIFDNILKGSRVLVDARDKLGIPWQHSENEKHGMFLMAFENKAGLPVEPATFQLYVPALSALWRDSGIREAFSRRSEFQLGESVKYFLDNLDRIGQLNYFPSKQDILLARKATKGIVEHDFVIKKIPFKMVDVGGQRSQRQKWFQCFDGITSILFMVSSSEYDQVLMEDRRTNRLVESMNIFETIVNNKLFFNVSIILFLNKMDLLVEKVKSVSIKKHFPDFKGDPHRLEDVQRYLVQCFDRKRRNRSKPLFHHFTTAIDTENIRFVFHAVKDTILQENLKDIMLQ
uniprot
proteins
function
FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems (PubMed:19151758, PubMed:21212405, PubMed:22609986). Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF12/LARG) (By similarity). GNA12-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1) (PubMed:19151758, PubMed:21212405). GNA12-dependent Rho signaling also regulates protein phosphatese 2A activation causing dephosphorylation of its target proteins (By similarity). Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway and up-regulating pro-inflammatory cytokine production (By similarity). Inhibits CDH1-mediated cell adhesion in process independent from Rho activation (By similarity). Together with NAPA promotes CDH5 localization to plasma membrane (By similarity). May play a role in the control of cell migration through the TOR signaling cascade (PubMed:22609986). {ECO:0000250|UniProtKB:Q03113, ECO:0000269|PubMed:19151758, ECO:0000269|PubMed:21212405, ECO:0000269|PubMed:22609986}.
uniprot
proteins
mass_dalton
44095
uniprot
proteins
mutagenesis
MUTAGEN 2; /note="S->G: Results in myristoylation of G-2, which restores the transformation activity; when associated with S-6."; /evidence="ECO:0000269|PubMed:9485474"; MUTAGEN 6; /note="R->S: Results in myristoylation of G-2, which restores the transformation activity; when associated with G-2."; /evidence="ECO:0000269|PubMed:9485474"; MUTAGEN 11; /note="C->S: Abolishes palmitoylation and transformation activity."; /evidence="ECO:0000269|PubMed:9485474
uniprot
proteins
post_translational_modification
PTM: Myristoylation of mutated N-terminus in place of original palmitoylation restores the transformation activity. {ECO:0000269|PubMed:9485474}.
uniprot
proteins
protein_family
G(12) subfamily
uniprot
proteins
protein_family
G-alpha family
uniprot
proteins
pubmed
15240885
uniprot
proteins
pubmed
16388592
uniprot
proteins
pubmed
1905812
uniprot
proteins
pubmed
19151758
uniprot
proteins
pubmed
21212405
uniprot
proteins
pubmed
22609986
uniprot
proteins
pubmed
2508088
uniprot
proteins
pubmed
9485474
uniprot
proteins
sequence_length
379
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:9485474}; Peripheral membrane protein {ECO:0000269|PubMed:9485474}; Cytoplasmic side {ECO:0000305|PubMed:9485474}. Lateral cell membrane {ECO:0000250|UniProtKB:Q03113}; Peripheral membrane protein {ECO:0000269|PubMed:9485474}; Cytoplasmic side {ECO:0000305|PubMed:9485474}. Cytoplasm {ECO:0000250|UniProtKB:Q03113}. Note=Associated to the plasma membrane via lipid-anchor (PubMed:9485474). CDH1 enhances cell membrane localization (By similarity). {ECO:0000250|UniProtKB:Q03113, ECO:0000269|PubMed:9485474}.
uniprot
proteins