BRF2
entrez
55290
canonical
uniprot
Q9HAW0
canonical
ensembl
ENSG00000104221
resolver
ensp
ENSP00000220659
resolver
genesymbol
BRF2
resolver
genesymbol_syn
BRFU
resolver
hgnc
HGNC:17298
resolver
uniprot
B2RD62
resolver
uniprot
B4DFZ6
resolver
uniprot
D3DSW6
resolver
uniprot
Q9H2Y3
resolver
uniprot
Q9H3B3
resolver
uniprot
Q9NUY6
resolver
uniprot_entry
BRF2_HUMAN
resolver
uniprot_sec
B2RD62
resolver
uniprot_sec
B4DFZ6
resolver
uniprot_sec
D3DSW6
resolver
uniprot_sec
Q9H2Y3
resolver
uniprot_sec
Q9H3B3
resolver
uniprot_sec
Q9NUY6
resolver
amino_acid_sequence
MPGRGRCPDCGSTELVEDSHYSQSQLVCSDCGCVVTEGVLTTTFSDEGNLREVTYSRSTGENEQVSRSQQRGLRRVRDLCRVLQLPPTFEDTAVAYYQQAYRHSGIRAARLQKKEVLVGCCVLITCRQHNWPLTMGAICTLLYADLDVFSSTYMQIVKLLGLDVPSLCLAELVKTYCSSFKLFQASPSVPAKYVEDKEKMLSRTMQLVELANETWLVTGRHPLPVITAATFLAWQSLQPADRLSCSLARFCKLANVDLPYPASSRLQELLAVLLRMAEQLAWLRVLRLDKRSVVKHIGDLLQHRQSLVRSAFRDGTAEVETREKEPPGWGQGQGEGEVGNNSLGLPQGKRPASPALLLPPCMLKSPKRICPVPPVSTVTGDENISDSEIEQYLRTPQEVRDFQRAQAARQAATSVPNPP
uniprot
proteins
function
FUNCTION: General activator of RNA polymerase III transcription. Factor exclusively required for RNA polymerase III transcription of genes with promoter elements upstream of the initiation sites (PubMed:11040218, PubMed:11121026, PubMed:11564744, PubMed:26638071). Contributes to the regulation of gene expression; functions as activator in the absence of oxidative stress (PubMed:26638071). Down-regulates expression of target genes in response to oxidative stress (PubMed:26638071). Overexpression protects cells against apoptosis in response to oxidative stress (PubMed:26638071). {ECO:0000269|PubMed:11040218, ECO:0000269|PubMed:11121026, ECO:0000269|PubMed:11564744, ECO:0000269|PubMed:26638071}.
uniprot
proteins
mass_dalton
46533
uniprot
proteins
mutagenesis
MUTAGEN 110; /note="R->A: Decreases affinity for DNA."; /evidence="ECO:0000269|PubMed:26638071"; MUTAGEN 361; /note="C->A: Abolishes response to oxidative stress. Abolishes the decrease in the formation of a ternary complex with DNA and TBP in response to oxidative stress."; /evidence="ECO:0000269|PubMed:26638071"; MUTAGEN 361; /note="C->D: Impairs formation of a ternary complex with DNA and TBP."; /evidence="ECO:0000269|PubMed:26638071
uniprot
proteins
post_translational_modification
PTM: In response to oxidative stress, Cys-361 is reversibly oxidized to cysteine sulfenic acid. Oxidation of Cys-361 impairs formation of a ternary complex with TBP and DNA and down-regulates expression of target genes in response to oxidative stress. {ECO:0000269|PubMed:26638071}.
uniprot
proteins
protein_family
TFIIB family
uniprot
proteins
pubmed
11040218
uniprot
proteins
pubmed
11121026
uniprot
proteins
pubmed
11483580
uniprot
proteins
pubmed
11564744
uniprot
proteins
pubmed
12016223
uniprot
proteins
pubmed
12391172
uniprot
proteins
pubmed
12621023
uniprot
proteins
pubmed
14527415
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16227591
uniprot
proteins
pubmed
16769183
uniprot
proteins
pubmed
17505538
uniprot
proteins
pubmed
17624304
uniprot
proteins
pubmed
18669648
uniprot
proteins
pubmed
23186163
uniprot
proteins
pubmed
26638071
uniprot
proteins
sequence_length
419
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17505538}.
uniprot
proteins