Bid
entrez
12122
canonical
uniprot
P70444
canonical
ensembl
ENSMUSG00000004446
resolver
ensp
ENSMUSP00000004560
resolver
ensp
ENSMUSP00000125731
resolver
ensp
ENSMUSP00000275204
resolver
ensp
ENSMUSP00000275206
resolver
ensp
ENSMUSP00000275210
resolver
ensp
ENSMUSP00000336163
resolver
enst
ENSMUST00000004560
resolver
enst
ENSMUST00000160684
resolver
genesymbol
Bid
resolver
uniprot
Q99M39
resolver
uniprot_entry
BID_MOUSE
resolver
uniprot_sec
Q99M39
resolver
amino_acid_sequence
MDSEVSNGSGLGAEHITDLLVFGFLQSSGCTRQELEVLGRELPVQAYWEADLEDELQTDGSQASRSFNQGRIEPDSESQEEIIHNIARHLAQIGDEMDHNIQPTLVRQLAAQFMNGSLSEEDKRNCLAKALDEVKTAFPRDMENDKAMLIMTMLLAKKVASHAPSLLRDVFHTTVNFINQNLFSYVRNLVRNEMD
uniprot
proteins
function
FUNCTION: Induces caspases and apoptosis. Counters the protective effect of BCL2. {ECO:0000269|PubMed:9873064}.; FUNCTION: [BH3-interacting domain death agonist p15]: Induces caspase activation and apoptosis (PubMed:9727491, PubMed:9727492). Translocates to mitochondria following cleavage and disrupts the outer mitochondrial membrane leading to the release of cytochrome c (PubMed:9727491, PubMed:9727492, PubMed:9873064). {ECO:0000269|PubMed:9727491, ECO:0000269|PubMed:9727492, ECO:0000269|PubMed:9873064}.
uniprot
proteins
mass_dalton
21952
uniprot
proteins
mutagenesis
MUTAGEN 59; /note="D->A: Abolished cleavage and ability to promote release of release of cytochrome c."; /evidence="ECO:0000269|PubMed:9727492"; MUTAGEN 75; /note="D->A: Does not affect ability to promote release of release of cytochrome c."; /evidence="ECO:0000269|PubMed:9727492"; MUTAGEN 98; /note="D->A: Loss of proteolytical cleavage leading to the production of p11 BID."; /evidence="ECO:0000269|PubMed:9873064
uniprot
proteins
post_translational_modification
PTM: [BH3-interacting domain death agonist]: TNF induces caspase-mediated cleavage into a major p15 and minor p13 and p11 products (PubMed:9727491, PubMed:9727492, PubMed:9873064). Cleaved by CASP6 or CASP8 into a major p15 and minor p13 products, leading to release of cytochrome c (PubMed:9727491). Also cleaved by GZMK to generate p15 (By similarity). {ECO:0000250|UniProtKB:P55957, ECO:0000269|PubMed:9727491, ECO:0000269|PubMed:9727492, ECO:0000269|PubMed:9873064}.; PTM: [BH3-interacting domain death agonist p15]: Ubiquitinated by ITCH; ubiquitination results in proteasome-dependent degradation. {ECO:0000269|PubMed:20392206}.
uniprot
proteins
pubmed
10089878
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15899861
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
20392206
uniprot
proteins
pubmed
21183079
uniprot
proteins
pubmed
8918887
uniprot
proteins
pubmed
9727491
uniprot
proteins
pubmed
9727492
uniprot
proteins
pubmed
9873064
uniprot
proteins
sequence_length
195
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:9873064}. Mitochondrion membrane {ECO:0000269|PubMed:9873064}. Mitochondrion outer membrane {ECO:0000250|UniProtKB:P55957}. Note=When uncleaved, it is predominantly cytoplasmic. {ECO:0000269|PubMed:9873064}.; SUBCELLULAR LOCATION: [BH3-interacting domain death agonist p15]: Mitochondrion membrane {ECO:0000269|PubMed:9727491, ECO:0000269|PubMed:9873064}. Note=Translocates to mitochondria following cleavage. {ECO:0000269|PubMed:9727491}.; SUBCELLULAR LOCATION: [BH3-interacting domain death agonist p13]: Mitochondrion membrane {ECO:0000269|PubMed:9873064}. Note=Associated with the mitochondrial membrane. {ECO:0000269|PubMed:9873064}.
uniprot
proteins