KCTD6
entrez
200845
canonical
uniprot
Q8NC69
canonical
ensembl
ENSG00000168301
resolver
ensp
ENSP00000347188
resolver
ensp
ENSP00000384948
resolver
ensp
ENSP00000417490
resolver
ensp
ENSP00000533714
resolver
ensp
ENSP00000533717
resolver
ensp
ENSP00000533718
resolver
ensp
ENSP00000533719
resolver
ensp
ENSP00000602045
resolver
ensp
ENSP00000631638
resolver
ensp
ENSP00000631639
resolver
ensp
ENSP00000631640
resolver
enst
ENST00000355076
resolver
enst
ENST00000404589
resolver
enst
ENST00000490264
resolver
enst
ENST00000863654
resolver
enst
ENST00000863658
resolver
enst
ENST00000863659
resolver
enst
ENST00000863660
resolver
enst
ENST00000931986
resolver
enst
ENST00000961579
resolver
enst
ENST00000961580
resolver
enst
ENST00000961581
resolver
genesymbol
KCTD6
resolver
hgnc
HGNC:22235
resolver
uniprot
B3KNI5
resolver
uniprot
Q8NBS6
resolver
uniprot
Q8TCA6
resolver
uniprot_entry
KCTD6_HUMAN
resolver
uniprot_sec
B3KNI5
resolver
uniprot_sec
Q8NBS6
resolver
uniprot_sec
Q8TCA6
resolver
amino_acid_sequence
MDNGDWGYMMTDPVTLNVGGHLYTTSLTTLTRYPDSMLGAMFGGDFPTARDPQGNYFIDRDGPLFRYVLNFLRTSELTLPLDFKEFDLLRKEADFYQIEPLIQCLNDPKPLYPMDTFEEVVELSSTRKLSKYSNPVAVIITQLTITTKVHSLLEGISNYFTKWNKHMMDTRDCQVSFTFGPCDYHQEVSLRVHLMEYITKQGFTIRNTRVHHMSERANENTVEHNWTFCRLARKTDD
uniprot
proteins
function
FUNCTION: Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation (PubMed:22573887). {ECO:0000269|PubMed:21472142, ECO:0000269|PubMed:22573887}.
uniprot
proteins
mass_dalton
27610
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein ubiquitination.
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16303743
uniprot
proteins
pubmed
21472142
uniprot
proteins
pubmed
22573887
uniprot
proteins
pubmed
24307990
uniprot
proteins
pubmed
25974686
uniprot
proteins
pubmed
26334369
uniprot
proteins
pubmed
27152988
uniprot
proteins
pubmed
27621083
uniprot
proteins
pubmed
29293652
uniprot
proteins
sequence_length
237
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, M line {ECO:0000269|PubMed:22573887}. Note=Colocalizes with ANK1 isoform Mu17 at the M line in differentiated skeletal muscle cells and heart. {ECO:0000269|PubMed:22573887}.
uniprot
proteins