ST3GAL1
entrez
6482
canonical
uniprot
Q11201
canonical
ensembl
ENSG00000008513
resolver
ensp
ENSP00000428540
resolver
ensp
ENSP00000430515
resolver
ensp
ENSP00000497381
resolver
ensp
ENSP00000546431
resolver
ensp
ENSP00000546432
resolver
ensp
ENSP00000546433
resolver
ensp
ENSP00000546434
resolver
ensp
ENSP00000546436
resolver
ensp
ENSP00000546437
resolver
ensp
ENSP00000546439
resolver
ensp
ENSP00000546440
resolver
ensp
ENSP00000546441
resolver
ensp
ENSP00000546442
resolver
ensp
ENSP00000546443
resolver
ensp
ENSP00000546444
resolver
ensp
ENSP00000546445
resolver
ensp
ENSP00000546446
resolver
ensp
ENSP00000546447
resolver
ensp
ENSP00000546448
resolver
ensp
ENSP00000546450
resolver
ensp
ENSP00000546451
resolver
ensp
ENSP00000546452
resolver
ensp
ENSP00000546453
resolver
ensp
ENSP00000546454
resolver
ensp
ENSP00000546456
resolver
ensp
ENSP00000546457
resolver
ensp
ENSP00000546458
resolver
ensp
ENSP00000546459
resolver
ensp
ENSP00000546460
resolver
ensp
ENSP00000546461
resolver
ensp
ENSP00000546462
resolver
ensp
ENSP00000546463
resolver
ensp
ENSP00000546464
resolver
ensp
ENSP00000546465
resolver
ensp
ENSP00000546466
resolver
ensp
ENSP00000546467
resolver
ensp
ENSP00000582194
resolver
ensp
ENSP00000582195
resolver
ensp
ENSP00000611287
resolver
ensp
ENSP00000611288
resolver
ensp
ENSP00000611289
resolver
ensp
ENSP00000611290
resolver
ensp
ENSP00000611291
resolver
ensp
ENSP00000611292
resolver
ensp
ENSP00000611293
resolver
ensp
ENSP00000611294
resolver
ensp
ENSP00000611295
resolver
ensp
ENSP00000611298
resolver
ensp
ENSP00000611299
resolver
ensp
ENSP00000611300
resolver
ensp
ENSP00000611302
resolver
ensp
ENSP00000611303
resolver
ensp
ENSP00000611304
resolver
ensp
ENSP00000611306
resolver
ensp
ENSP00000611307
resolver
ensp
ENSP00000611308
resolver
ensp
ENSP00000611309
resolver
ensp
ENSP00000611310
resolver
ensp
ENSP00000611311
resolver
ensp
ENSP00000611312
resolver
ensp
ENSP00000611313
resolver
ensp
ENSP00000611314
resolver
ensp
ENSP00000611315
resolver
ensp
ENSP00000611316
resolver
ensp
ENSP00000611317
resolver
ensp
ENSP00000611318
resolver
ensp
ENSP00000611319
resolver
ensp
ENSP00000611320
resolver
ensp
ENSP00000611321
resolver
ensp
ENSP00000611322
resolver
ensp
ENSP00000611324
resolver
ensp
ENSP00000611325
resolver
enst
ENST00000521180
resolver
enst
ENST00000522652
resolver
enst
ENST00000648219
resolver
enst
ENST00000876372
resolver
enst
ENST00000876373
resolver
enst
ENST00000876374
resolver
enst
ENST00000876375
resolver
enst
ENST00000876377
resolver
enst
ENST00000876378
resolver
enst
ENST00000876380
resolver
enst
ENST00000876381
resolver
enst
ENST00000876382
resolver
enst
ENST00000876383
resolver
enst
ENST00000876384
resolver
enst
ENST00000876385
resolver
enst
ENST00000876386
resolver
enst
ENST00000876387
resolver
enst
ENST00000876388
resolver
enst
ENST00000876389
resolver
enst
ENST00000876391
resolver
enst
ENST00000876392
resolver
enst
ENST00000876393
resolver
enst
ENST00000876394
resolver
enst
ENST00000876395
resolver
enst
ENST00000876397
resolver
enst
ENST00000876398
resolver
enst
ENST00000876399
resolver
enst
ENST00000876400
resolver
enst
ENST00000876401
resolver
enst
ENST00000876402
resolver
enst
ENST00000876403
resolver
enst
ENST00000876404
resolver
enst
ENST00000876405
resolver
enst
ENST00000876406
resolver
enst
ENST00000876407
resolver
enst
ENST00000876408
resolver
enst
ENST00000912135
resolver
enst
ENST00000912136
resolver
enst
ENST00000941228
resolver
enst
ENST00000941229
resolver
enst
ENST00000941230
resolver
enst
ENST00000941231
resolver
enst
ENST00000941232
resolver
enst
ENST00000941233
resolver
enst
ENST00000941234
resolver
enst
ENST00000941235
resolver
enst
ENST00000941236
resolver
enst
ENST00000941239
resolver
enst
ENST00000941240
resolver
enst
ENST00000941241
resolver
enst
ENST00000941243
resolver
enst
ENST00000941244
resolver
enst
ENST00000941245
resolver
enst
ENST00000941247
resolver
enst
ENST00000941248
resolver
enst
ENST00000941249
resolver
enst
ENST00000941250
resolver
enst
ENST00000941251
resolver
enst
ENST00000941252
resolver
enst
ENST00000941253
resolver
enst
ENST00000941254
resolver
enst
ENST00000941255
resolver
enst
ENST00000941256
resolver
enst
ENST00000941257
resolver
enst
ENST00000941258
resolver
enst
ENST00000941259
resolver
enst
ENST00000941260
resolver
enst
ENST00000941261
resolver
enst
ENST00000941262
resolver
enst
ENST00000941263
resolver
enst
ENST00000941265
resolver
enst
ENST00000941266
resolver
genesymbol
ST3GAL1
resolver
genesymbol_syn
SIAT4
resolver
genesymbol_syn
SIAT4A
resolver
hgnc
HGNC:10862
resolver
uniprot
O60677
resolver
uniprot
Q9UN51
resolver
uniprot_entry
SIA4A_HUMAN
resolver
uniprot_sec
O60677
resolver
uniprot_sec
Q9UN51
resolver
amino_acid_sequence
MVTLRKRTLKVLTFLVLFIFLTSFFLNYSHTMVATTWFPKQMVLELSENLKRLIKHRPCTCTHCIGQRKLSAWFDERFNQTMQPLLTAQNALLEDDTYRWWLRLQREKKPNNLNDTIKELFRVVPGNVDPMLEKRSVGCRRCAVVGNSGNLRESSYGPEIDSHDFVLRMNKAPTAGFEADVGTKTTHHLVYPESFRELGDNVSMILVPFKTIDLEWVVSAITTGTISHTYIPVPAKIRVKQDKILIYHPAFIKYVFDNWLQGHGRYPSTGILSVIFSMHVCDEVDLYGFGADSKGNWHHYWENNPSAGAFRKTGVHDADFESNVTATLASINKIRIFKGR
uniprot
proteins
ec_number
2.4.3.2
uniprot
proteins
ec_number
2.4.3.4
uniprot
proteins
function
FUNCTION: A beta-galactoside alpha2->3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids (PubMed:31784620, PubMed:8027041). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:31784620, PubMed:8027041, PubMed:31719620). Adds sialic acid to the core 1 O-glycan, Galbeta-(1->3)-GalNAc-O-Ser/Thr, which is a major structure of mucin-type O-glycans. As part of a homeostatic mechanism that regulates CD8-positive T cell numbers, sialylates core 1 O-glycans of T cell glycoproteins, SPN/CD43 and PTPRC/CD45. Prevents premature apoptosis of thymic CD8-positive T cells prior to peripheral emigration, whereas in the secondary lymphoid organs controls the survival of CD8-positive memory T cells generated following a successful immune response (By similarity). Transfers sialic acid to asialofetuin, presumably onto Galbeta-(1->3)-GalNAc-O-Ser (By similarity). Sialylates GM1a, GA1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively (By similarity) (PubMed:8027041). {ECO:0000250|UniProtKB:P54751, ECO:0000269|PubMed:31719620, ECO:0000269|PubMed:31784620, ECO:0000269|PubMed:8027041}.
uniprot
proteins
mass_dalton
39075
uniprot
proteins
mutagenesis
MUTAGEN 59; /note="C->S: Has no effect on the catalytic efficiency; when associated with S-64."; /evidence="ECO:0000269|PubMed:31784620"; MUTAGEN 61; /note="C->S: Loss of the catalytic activity; when associated with S-139."; /evidence="ECO:0000269|PubMed:31784620"; MUTAGEN 64; /note="C->S: Has no effect on the catalytic efficiency; when associated with S-59."; /evidence="ECO:0000269|PubMed:31784620"; MUTAGEN 139; /note="C->S: Loss of the catalytic activity; when associated with S-61."; /evidence="ECO:0000269|PubMed:31784620"; MUTAGEN 142; /note="C->S: Loss of the catalytic activity; when associated with S-281."; /evidence="ECO:0000269|PubMed:31784620"; MUTAGEN 147; /note="N->S: Decreases the affinity and the specific activity for both donor and acceptor substrates. Decreases the catalytic efficiency for the donor and acceptor substrates by 17- and 32-fold, respectively."; /evidence="ECO:0000269|PubMed:31784620"; MUTAGEN 148; /note="S->A: Decreases the affinity for the donor and acceptor substrates by 4.5- and 4-fold, respectively. Almost no change in specific activity."; /evidence="ECO:0000269|PubMed:31784620"; MUTAGEN 170; /note="N->A: Decreases the affinity and the catalytic efficiency for both donor and acceptor substrates."; /evidence="ECO:0000269|PubMed:31784620"; MUTAGEN 191; /note="Y->A: Drastic decrease of the catalytic efficiency for both donor and acceptor substrates by 44- and 115-fold, respectively."; /evidence="ECO:0000269|PubMed:31784620"; MUTAGEN 230; /note="Y->A: Decreases the catalytic efficiency for the donor and acceptor substrates by 2.5- and 35-fold, respectively."; /evidence="ECO:0000269|PubMed:31784620"; MUTAGEN 230; /note="Y->F: Decreases the catalytic efficiency for the donor and acceptor substrates by 2- and 12-fold, respectively."; /evidence="ECO:0000269|PubMed:31784620"; MUTAGEN 281; /note="C->S: Loss of the catalytic activity; when associated with S-142."; /evidence="ECO:0000269|PubMed:31784620"; MUTAGEN 315; /note="V->A: Decreases the catalytic efficiency for the donor and acceptor substrates by 5- and 70-fold, respectively."; /evidence="ECO:0000269|PubMed:31784620"; MUTAGEN 315; /note="V->Y: Drastic decrease of the catalytic efficiency for both donor and acceptor substrates by 67- and 344-fold, respectively. Does not change the enzyme regioselectivity."; /evidence="ECO:0000269|PubMed:31784620
uniprot
proteins
pathway_participation
PATHWAY: Protein modification; protein glycosylation. {ECO:0000305|PubMed:8027041}.; PATHWAY: Glycolipid biosynthesis. {ECO:0000305|PubMed:8027041}.
uniprot
proteins
post_translational_modification
PTM: The soluble form derives from the membrane form by proteolytic processing.
uniprot
proteins
protein_family
Glycosyltransferase 29 family
uniprot
proteins
pubmed
10504389
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
31719620
uniprot
proteins
pubmed
31784620
uniprot
proteins
pubmed
7655169
uniprot
proteins
pubmed
8027041
uniprot
proteins
pubmed
9182658
uniprot
proteins
sequence_length
340
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack membrane {ECO:0000269|PubMed:9182658}; Single-pass type II membrane protein {ECO:0000255}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:9182658}; Single-pass type II membrane protein {ECO:0000255}. Secreted. Note=Membrane-bound form in medial and trans cisternae of Golgi (PubMed:9182658). Secreted into the body fluid. {ECO:0000269|PubMed:9182658}.
uniprot
proteins
transmembrane_region
TRANSMEM 14..34; /note="Helical; Signal-anchor for type II membrane protein"; /evidence="ECO:0000255
uniprot
proteins