Epop
entrez
103551
canonical
uniprot
Q7TNS8
canonical
ensembl
ENSMUSG00000043439
resolver
ensp
ENSMUSP00000051211
resolver
enst
ENSMUST00000052281
resolver
genesymbol
Epop
resolver
genesymbol_syn
E13
resolver
uniprot
Q8BN79
resolver
uniprot
Q99JK6
resolver
uniprot_entry
EPOP_MOUSE
resolver
uniprot_sec
Q8BN79
resolver
uniprot_sec
Q99JK6
resolver
amino_acid_sequence
METLCPPPRLAVPASPRGSPCSPTPLKPRRGTPEFSPLCLRALAFCALAKPRPSSLGLGPGELAPRTPVLLGPPASPCTGGWAADGLKHLGGQAGRPSDVSSPAREDADVAVCPGGGEEEEGGGGFPHFGAGSCAPPGRCPAPLRPQDSPTNPAWSPPRPARGLDAASSPPLEPGSPPPSPPAGLSPEPAPSEQPVPASEAPGGGDPAPTAPEAPALSPSTADAAPDPPRDLRQEHFNRLIRRSKLWCYAKGFALDTPSLRRGPERPAAKARGAAKKRRRPAPPPPSVQPRRPVPTLPTSSTFSLLDCFPCPPALVVEENGDLGPASSLRLQGDAKPPPAHPLWKWQMGGPAVPEPPGLKSWWVNLEEL
uniprot
proteins
function
FUNCTION: Scaffold protein that serves as a bridging partner between the PRC2/EZH2 complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs) (PubMed:27863225, PubMed:27863226). Plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression at PcG target genes: acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EZH2 complex (PubMed:27863225, PubMed:27863226). Interaction with USP7 promotes deubiquitination of H2B at promoter sites (PubMed:27863226). Acts as a regulator of neuronal differentiation (PubMed:23180766). {ECO:0000269|PubMed:23180766, ECO:0000269|PubMed:27863225, ECO:0000269|PubMed:27863226}.
uniprot
proteins
mass_dalton
38095
uniprot
proteins
mutagenesis
MUTAGEN 40; /note="L->A: Abolishes interaction with the elongin BC complex."; /evidence="ECO:0000269|PubMed:27863225, ECO:0000269|PubMed:27863226
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
16141072
uniprot
proteins
pubmed
19468303
uniprot
proteins
pubmed
21732481
uniprot
proteins
pubmed
23180766
uniprot
proteins
pubmed
27462409
uniprot
proteins
pubmed
27863225
uniprot
proteins
pubmed
27863226
uniprot
proteins
pubmed
28061330
uniprot
proteins
sequence_length
369
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:27863225}. Chromosome {ECO:0000269|PubMed:27863225, ECO:0000269|PubMed:27863226}. Note=Localizes at both PRC2/EZH2 sites (H3K27me3) and broad H3K4me3 sites on chromatin of embryonic stem cells (ESCs) (PubMed:27863226). {ECO:0000269|PubMed:27863226}.
uniprot
proteins