DPEP3
entrez
64180
canonical
uniprot
Q9H4B8
canonical
ensembl
ENSG00000141096
resolver
ensp
ENSP00000268793
resolver
ensp
ENSP00000546690
resolver
enst
ENST00000268793
resolver
genesymbol
DPEP3
resolver
hgnc
HGNC:23029
resolver
uniprot
A0A140VK16
resolver
uniprot
B3KQ48
resolver
uniprot
Q6PEZ5
resolver
uniprot
Q6UXE4
resolver
uniprot_entry
A0A140VK16_HUMAN
resolver
uniprot_entry
DPEP3_HUMAN
resolver
uniprot_sec
B3KQ48
resolver
uniprot_sec
Q6PEZ5
resolver
uniprot_sec
Q6UXE4
resolver
amino_acid_sequence
MQPTGREGSRALSRRYLRRLLLLLLLLLLRQPVTRAETTPGAPRALSTLGSPSLFTTPGVPSALTTPGLTTPGTPKTLDLRGRAQALMRSFPLVDGHNDLPQVLRQRYKNVLQDVNLRNFSHGQTSLDRLRDGLVGAQFWSASVSCQSQDQTAVRLALEQIDLIHRMCASYSELELVTSAEGLNSSQKLACLIGVEGGHSLDSSLSVLRSFYVLGVRYLTLTFTCSTPWAESSTKFRHHMYTNVSGLTSFGEKVVEELNRLGMMIDLSYASDTLIRRVLEVSQAPVIFSHSAARAVCDNLLNVPDDILQLLKKNGGIVMVTLSMGVLQCNLLANVSTVADHFDHIRAVIGSEFIGIGGNYDGTGRFPQGLEDVSTYPVLIEELLSRSWSEEELQGVLRGNLLRVFRQVEKVREESRAQSPVEAEFPYGQLSTSCHSHLVPQNGHQATHLEVTKQPTNRVPWRSSNASPYLVPGLVAAATIPTFTQWLC
uniprot
proteins
function
FUNCTION: Lacks dipeptidase activity and is unable to hydrolyze cystinyl-bis-glycine, leukotriene D4 and the beta-lactam antibiotic imipenem (PubMed:32325220). The absence of activity may be due to the inability of asparagine (instead of aspartate found in DPEP1/2) at position 359 to function as the acid/base catalyst and activate the nucleophilic water/hydroxide (PubMed:32325220). A tyrosine (instead of histidine) at position 269 reduces affinity for the beta zinc and may cause substrate steric hindrance (PubMed:32325220). {ECO:0000269|PubMed:32325220}.
uniprot
proteins
mass_dalton
53687
uniprot
proteins
mutagenesis
MUTAGEN 196; /note="E->A: Loss of zinc binding."; /evidence="ECO:0000269|PubMed:32325220
uniprot
proteins
protein_family
Metallo-dependent hydrolases superfamily
uniprot
proteins
protein_family
Peptidase M19 family
uniprot
proteins
pubmed
12975309
uniprot
proteins
pubmed
14702039
uniprot
proteins
pubmed
15489334
uniprot
proteins
pubmed
15616553
uniprot
proteins
pubmed
32325220
uniprot
proteins
sequence_length
488
uniprot
proteins
subcellular_location
SUBCELLULAR LOCATION: Membrane {ECO:0000250|UniProtKB:Q9DA79}; Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q9DA79}.
uniprot
proteins